                         SEQUENCE LISTING

<110>  Genizon BioSciences
 
<120>  GeneMap of the human genes associated with psoriasis

<130>  Abdelmajid Belouchi, John Verner Raelson, Walter Edward Bradley, Bruno Paquin, 
Quynh Nguyen-Huu, Pascal Croteau, Rene Allard, Randall David Little, Sophie Debrus, Johanne Cousineau, 
Tim Keith, Natali Henderson, Daniel Dubois, Paul Van Eerdewegh and Jonathan Segal.

<160>  40189 

<170>  PatentIn version 3.3

<210>  1
<211>  1809
<212>  DNA
<213>  Homosapiens

<400>  1
acgccggcgc tcccaggccg cgcttcctgc gtccccaacc cggtccctga gagggcactg     60

cgccctctcc accactgcgt tccctcggct aagaatcccc cgaaccccag ccccgcgatc    120

gcggcgccca ccgaggaggc cgcccgggtg gggcgcgggg gtcgcgaagc ccgcagcccc    180

ggaccgccca gccgagacgg agccggaccc gccgcctccc gggcccttcc accgcagcta    240

tccgcacggg aggcctcgcg attgctcgga accatcccgc aggagttcag ctgatatttt    300

ctagtgtggg gcgagagatt ttgtggagcg catttaaggg gtttttgttg tgactgctgc    360

cttgtatata tttattttct ttcttggaac tgggcctcgc cctcctccca ctgacatgat    420

ggcccagtcc aaggccaatg gctcgcacta tgcgctgacc gccatcggcc tggggatgct    480

ggtccttggg gtgatcatgg ccatgtggaa cctggtaccc ggcttcagcg cggccgagaa    540

gccaacagct cagggcagca acaagaccga ggtgggtggc ggcatcctca agagcaagac    600

cttctctgtg gcctacgtgc tggtcggggc cggggtgatg ctgctgctgc tttctatctg    660

cctgagtatc agggataaga ggaagcagcg gcagggcgag gacctggccc atgtccagca    720

cccgacaggc gctgggcctc acgcccagga ggaagacagc caggaggaag aagaggagga    780

tgaggaggct gcctcaaggt actatgttcc cagctacgag gaagtgatga acacaaacta    840

ctcagaagca aggggagagg agcagaaccc gaggttgagc atctctctcc cgtcctatga    900

gtcactgacg gggctcgacg agaccacccc cacatccacc agggctgacg tggaggccag    960

ccctgggaac ccccctgaca ggcagaactc taagttggcc aaacgactga aaccgctgaa   1020

agttcgaagg attaaatctg aaaagcttca cctcaaagac tttaggatca acctcccaga   1080

caaaaacgtc cctcctccct cgatagagcc tttgactcct ccaccgcagt atgatgaagt   1140

ccaggagaag gcccccgaca cccggccgcc cgactgaatg gccccacttg agccacgctc   1200

cctcctgtct ctcacacctt tcacccccaa gactctaaca aagccacatg agccacagtt   1260

gagaagcgga ggggccagct gtgcatggag ccatttggat ggcggcgggc gggggggatt   1320

ctctgtatca ggagtgactt tgttgcccca cacagcctcc tgctgcaggt gctttggaaa   1380

gagatgctgc cttggagctg gtgaatctgt ggaccacatt caagggtgtg gcacaggcat   1440

cttcccatcc ttttcactcc gaatcgctgg cgacacattc tcctttccag ctaggaaagg   1500

gttcctcgcg gctggtttag attgtggttg tttgttttgc ttctactaag actgttttgt   1560

ttcaaaaagg aaacaaattt tgtgtttgct gtctacgctg gagtcctgaa ctgtgggtag   1620

aaaacacgac ctggctttgt agaaaggaca cagggctgtt ttatgaacta agcggtgagg   1680

ctcaggtggc ggctctcaca gagcccctga tgctgttgtt ctttgagggc ttaaggcctg   1740

atgaacgtag gcacgtgatg cgtaatagtc ttcaatggta cacttaacta gtctcttctg   1800

tgtaacagc                                                           1809


<210>  2
<211>  253
<212>  PRT
<213>  Homosapiens

<400>  2

Met Met Ala Gln Ser Lys Ala Asn Gly Ser His Tyr Ala Leu Thr Ala 
1               5                   10                  15      


Ile Gly Leu Gly Met Leu Val Leu Gly Val Ile Met Ala Met Trp Asn 
            20                  25                  30          


Leu Val Pro Gly Phe Ser Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser 
        35                  40                  45              


Asn Lys Thr Glu Val Gly Gly Gly Ile Leu Lys Ser Lys Thr Phe Ser 
    50                  55                  60                  


Val Ala Tyr Val Leu Val Gly Ala Gly Val Met Leu Leu Leu Leu Ser 
65                  70                  75                  80  


Ile Cys Leu Ser Ile Arg Asp Lys Arg Lys Gln Arg Gln Gly Glu Asp 
                85                  90                  95      


Leu Ala His Val Gln His Pro Thr Gly Ala Gly Pro His Ala Gln Glu 
            100                 105                 110         


Glu Asp Ser Gln Glu Glu Glu Glu Glu Asp Glu Glu Ala Ala Ser Arg 
        115                 120                 125             


Tyr Tyr Val Pro Ser Tyr Glu Glu Val Met Asn Thr Asn Tyr Ser Glu 
    130                 135                 140                 


Ala Arg Gly Glu Glu Gln Asn Pro Arg Leu Ser Ile Ser Leu Pro Ser 
145                 150                 155                 160 


Tyr Glu Ser Leu Thr Gly Leu Asp Glu Thr Thr Pro Thr Ser Thr Arg 
                165                 170                 175     


Ala Asp Val Glu Ala Ser Pro Gly Asn Pro Pro Asp Arg Gln Asn Ser 
            180                 185                 190         


Lys Leu Ala Lys Arg Leu Lys Pro Leu Lys Val Arg Arg Ile Lys Ser 
        195                 200                 205             


Glu Lys Leu His Leu Lys Asp Phe Arg Ile Asn Leu Pro Asp Lys Asn 
    210                 215                 220                 


Val Pro Pro Pro Ser Ile Glu Pro Leu Thr Pro Pro Pro Gln Tyr Asp 
225                 230                 235                 240 


Glu Val Gln Glu Lys Ala Pro Asp Thr Arg Pro Pro Asp 
                245                 250             


<210>  3
<211>  4625
<212>  DNA
<213>  Homosapiens

<400>  3
ccatgtaaga agtgcttttc gcctcccacc atgattctga ggcctccccg gccatgtgga     60

actatcagtg ccctacagaa aggctacagc aaggtgctgt gccagaccct gtcagagcgg    120

aactcagaaa tcacatccct gaagaatgag ggcgagaact taaagagaga caacgctatc    180

acatcaggga tggtgtcatc tttgcaaaaa gacatattag caaaggatga gcaagttcaa    240

caactaaagg aagaggtcag tcacctaaaa agtcagaaca aggacaagga ccaccagctg    300

gaagcccttg gctctagatg ctcggtgcta aaggaagagt taaaacagga agatgctcac    360

agggagctca gggaagccca ggagaaagag ttaaaactct gcaaaaccca aatccaagac    420

atggagaaag aaatgaagaa gcttagggca gagctgagga agagttgtac tgaacaaagc    480

gtgatctcta ggactctgag agaaaaaagc aaggttgaag agaagcttca ggaggattcc    540

agaaggaaat tgcttcagct gcaagaaatg gggaacagag agagcgtcat taaaatcaat    600

ttggagaggg cagtaggtca gctggagcac ttcagaagtc aagtcatcaa ggccacctat    660

ggacgggcga agccgttccg ggacaagccc gtcaccgacc aacagttaat agagaaaatt    720

acccaggtca ctgaggacaa catcaatttt cagcagaaaa agtggaccct ccagaaagag    780

acccagctga gcaactccaa gcaggaggag accaccgaga acatcgagaa gctgaggacg    840

tcgctggaca gctgccaggc ttgcatgaaa atatcctgtt gcagccatga cctgaagaag    900

gaggtcgacc ttcttcagca cctccaggtg agcccacctg tctcggggct ccagaaggtg    960

gtgctggacg tcctgaggca cgcgctgtcc tggctggagg aggtggagca gctcctccgg   1020

gacctcggga tcctgccctc cagccccaac aaagggttct ctttgtatct gatatatctt   1080

ctggaacatt ataaaaaact tatgagccag gcccaggaac ttcagatcaa gttcaacagt   1140

tctcaggaaa ctcagcagtc tttactgcag gaaaagctgc gggagcatct ggcagagaag   1200

gagaagctga acgaggagag gctagagcaa gaggagaagc tcaaagccaa aatcaggcaa   1260

ctgacggaag agaaggcggc tttggaggag tacattactc aagagagaaa cagagcgaaa   1320

gagactttag aggaagaacg gaagagaatg caagaactgg agagcctcct ggcccagcag   1380

aagaaggctt tggcgaaaag cattacccag gagaagaaca gagtgaagga agcattagag   1440

gaagagcaga caagagtcca agagctggag gaacgcttgg cccgccagaa ggagatctca   1500

gagagcaaca ttgcgtacga gaaacgcaaa gcaaaggagg ccatggagaa ggaaaagaaa   1560

aaggtgcaag acctggagaa tcgcttaacc aagcagaaag aggaattaga attaaaagag   1620

caaaaagagg acgttttaaa taataaatta agtgacgcac tggccatggt tgaagagact   1680

cagaaaacaa aggcaactga aagtctaaaa gcagagagcc tcgccttgaa attaaatgaa   1740

acattagccg aactggaaac taccaagaca aaaatgatca tggtggaaga gcggctaatc   1800

ctgcagcaga agatggtaaa ggccctccag gatgagcagg aatcacagag acacgggttt   1860

gaagaagaga tcatggaata taaggagcaa atcaaacagc acgcccagac aattgtgagc   1920

ctcgaagaga aactccagaa agtcactcag caccataaaa aaatagaagg cgagattgca   1980

acattgaagg acaatgaccc agccccaaag gaggaaaggc cgcaagaccc tctggtggct   2040

cccatgacag agagcagtgc caaagacatg gcgtacgaac atctgataga tgacttattg   2100

gctgctcaga aggaaattct gtctcagcag gaagtcatca tgaagttaag gaaagacctt   2160

accgaagccc acagcagaat gtcggatttg agaggggagc taaacgagaa gcagaagatg   2220

gaactggagc agaacgtggt gctggtccag cagcagagca aggagctgag tgtgctcaag   2280

gagaagatgg cccagatgag cagcctggta gaaaagaaag atcgggagct gaaggccctt   2340

gaggaggcac tcagggcttc ccaagagaaa cacagactcc agctgaacac agagaaggaa   2400

cagaagcccc ggaagaagac ccagacgtgt gacacctctg tgcagataga acccgtccac   2460

actgaggcct tctccagcag ccaagagcag caatccttca gcgatctagg ggtcaggtgc   2520

aaagggtccc ggcacgagga ggtcattcag cgtcagaaaa aggccttatc tgaacttcga   2580

gcgcgaatta aagaactcga gaaggcgcgc tcaccagatc ataaagacca ccagaatgaa   2640

tcatttctag atttaaagaa cctcagaatg gaaaacaatg tccagaaaat actactggat   2700

gcaaaaccgg atttgccaac tctctcaaga atagagatcc tagcgcctca gaatggcctt   2760

tgcaacgcaa ggttcggctc agccatggag aagtcaggga agatggatgt ggctgaggct   2820

ttagagctca gtgaaaagct gtacctggat atgagcaaaa ccctcggaag tctcatgaac   2880

atcaagaata tgtcaggcca cgtgtccatg aaatacctct cccgccagga gagggagaag   2940

gtcaaccagc ttcgacaaag ggacctcgac ctggtgtttg ataagatcac ccaactcaag   3000

aaccagctgg ggaggaaaga ggagctgttg agaggatatg aaaaggacgt tgaacagctc   3060

aggcggagca aagtgtccat tgagatgtac cagtcgcagg tggcaaagct ggaggatgat   3120

atctacaaag aggccgaaga gaaggccctg ctgaaggagg ccctggagcg catggagcac   3180

cagctgtgcc aggagaagag gatcaacagg gccatccggc agcagaagta gatgggagct   3240

tccagcccct gcctcgcaga cagatggtga ggatgaaaga atgcaggcat ccctcgctat   3300

ctgctgtcca ctctcgctgt cgtcatacct caggagccaa gtgcttttgg atggtgaggg   3360

tgcttgtccc gtctctgaag cacctgccca gggcctggca ccagccggcg gacactgcct   3420

tccccatgct gcccatgacc catgctgccc gtgacccatg caggtggtct cctgggtgag   3480

tcctgcctca gacccggtag ggtctacaca ctggaaagtt tccccaaagc aagtcacaca   3540

tgagcagcac ccgggcggct tccaaagctc cctgaaagct ggcagagggg ctttcctgtc   3600

tgctttgcag ttgacatatt catcatccac tcctgcagtc cacaaggcac tggaacagtg   3660

acctctaaat agagccagac tctccctttc cttcactctt gcctaaggtg gagcagatcc   3720

caaggctggg gttaggcaag tcagggaaag aaccacagtc actgtttctt catgaccgtc   3780

tccaggccag ggactgggct cacctgagct ttgcagccgt gatagggctt attaatgcct   3840

ctaatagccc tgcctggtac gatgatccct attttacaga tgaggaaact gcgcctcaga   3900

gagttaagag gcgcccaagt gcacacagcg gctggtaagg acagctggga cctgacccca   3960

gatccctctg accctggttc tcctgctgtc tgcagggttg gccgtgagtc ccctccttgt   4020

aactgtcagc ttttatgtgt gtgtgcattc tcgtgtgtgt gtacattctc atgtgtgtgt   4080

gtgtgtgcac atgtgtacca tgtgcatgag ggtttggctg tgtgtgacac tatgtgtgtg   4140

tgtttgtgtg tgttgcctgc ctgagctcag agagagccaa acccccagag aagggtgccc   4200

cctccaccaa ccaggtgagc tccttgcaga ggcctggcct tcatcccaca aaccttgcag   4260

accacaggct ccctggcttg cagcccccaa aaatgaaggc agcgctctgc tctggacgtg   4320

gcctttccag cactcaccac tctgaattaa acatcacagg cccccatctg cacatgtcgt   4380

ggggctgcct cgggcagagg accgtttcct tttacgctgt gccatgccag ggagatctgg   4440

gcagcagcag agtcctgaga tgtcctttga tgtacccaca ggagagttcg ctccttcccg   4500

aggcagtgtc ccccagggct tggcaggcca ggcccacagc agagacacca aaccacagaa   4560

tgggacggca gagggcccta aaaagcccat tgtcatgcac tggctgaaaa tgaaagaaaa   4620

cctgc                                                               4625


<210>  4
<211>  1066
<212>  PRT
<213>  Homosapiens

<400>  4

Met Ile Leu Arg Pro Pro Arg Pro Cys Gly Thr Ile Ser Ala Leu Gln 
1               5                   10                  15      


Lys Gly Tyr Ser Lys Val Leu Cys Gln Thr Leu Ser Glu Arg Asn Ser 
            20                  25                  30          


Glu Ile Thr Ser Leu Lys Asn Glu Gly Glu Asn Leu Lys Arg Asp Asn 
        35                  40                  45              


Ala Ile Thr Ser Gly Met Val Ser Ser Leu Gln Lys Asp Ile Leu Ala 
    50                  55                  60                  


Lys Asp Glu Gln Val Gln Gln Leu Lys Glu Glu Val Ser His Leu Lys 
65                  70                  75                  80  


Ser Gln Asn Lys Asp Lys Asp His Gln Leu Glu Ala Leu Gly Ser Arg 
                85                  90                  95      


Cys Ser Val Leu Lys Glu Glu Leu Lys Gln Glu Asp Ala His Arg Glu 
            100                 105                 110         


Leu Arg Glu Ala Gln Glu Lys Glu Leu Lys Leu Cys Lys Thr Gln Ile 
        115                 120                 125             


Gln Asp Met Glu Lys Glu Met Lys Lys Leu Arg Ala Glu Leu Arg Lys 
    130                 135                 140                 


Ser Cys Thr Glu Gln Ser Val Ile Ser Arg Thr Leu Arg Glu Lys Ser 
145                 150                 155                 160 


Lys Val Glu Glu Lys Leu Gln Glu Asp Ser Arg Arg Lys Leu Leu Gln 
                165                 170                 175     


Leu Gln Glu Met Gly Asn Arg Glu Ser Val Ile Lys Ile Asn Leu Glu 
            180                 185                 190         


Arg Ala Val Gly Gln Leu Glu His Phe Arg Ser Gln Val Ile Lys Ala 
        195                 200                 205             


Thr Tyr Gly Arg Ala Lys Pro Phe Arg Asp Lys Pro Val Thr Asp Gln 
    210                 215                 220                 


Gln Leu Ile Glu Lys Ile Thr Gln Val Thr Glu Asp Asn Ile Asn Phe 
225                 230                 235                 240 


Gln Gln Lys Lys Trp Thr Leu Gln Lys Glu Thr Gln Leu Ser Asn Ser 
                245                 250                 255     


Lys Gln Glu Glu Thr Thr Glu Asn Ile Glu Lys Leu Arg Thr Ser Leu 
            260                 265                 270         


Asp Ser Cys Gln Ala Cys Met Lys Ile Ser Cys Cys Ser His Asp Leu 
        275                 280                 285             


Lys Lys Glu Val Asp Leu Leu Gln His Leu Gln Val Ser Pro Pro Val 
    290                 295                 300                 


Ser Gly Leu Gln Lys Val Val Leu Asp Val Leu Arg His Ala Leu Ser 
305                 310                 315                 320 


Trp Leu Glu Glu Val Glu Gln Leu Leu Arg Asp Leu Gly Ile Leu Pro 
                325                 330                 335     


Ser Ser Pro Asn Lys Gly Phe Ser Leu Tyr Leu Ile Tyr Leu Leu Glu 
            340                 345                 350         


His Tyr Lys Lys Leu Met Ser Gln Ala Gln Glu Leu Gln Ile Lys Phe 
        355                 360                 365             


Asn Ser Ser Gln Glu Thr Gln Gln Ser Leu Leu Gln Glu Lys Leu Arg 
    370                 375                 380                 


Glu His Leu Ala Glu Lys Glu Lys Leu Asn Glu Glu Arg Leu Glu Gln 
385                 390                 395                 400 


Glu Glu Lys Leu Lys Ala Lys Ile Arg Gln Leu Thr Glu Glu Lys Ala 
                405                 410                 415     


Ala Leu Glu Glu Tyr Ile Thr Gln Glu Arg Asn Arg Ala Lys Glu Thr 
            420                 425                 430         


Leu Glu Glu Glu Arg Lys Arg Met Gln Glu Leu Glu Ser Leu Leu Ala 
        435                 440                 445             


Gln Gln Lys Lys Ala Leu Ala Lys Ser Ile Thr Gln Glu Lys Asn Arg 
    450                 455                 460                 


Val Lys Glu Ala Leu Glu Glu Glu Gln Thr Arg Val Gln Glu Leu Glu 
465                 470                 475                 480 


Glu Arg Leu Ala Arg Gln Lys Glu Ile Ser Glu Ser Asn Ile Ala Tyr 
                485                 490                 495     


Glu Lys Arg Lys Ala Lys Glu Ala Met Glu Lys Glu Lys Lys Lys Val 
            500                 505                 510         


Gln Asp Leu Glu Asn Arg Leu Thr Lys Gln Lys Glu Glu Leu Glu Leu 
        515                 520                 525             


Lys Glu Gln Lys Glu Asp Val Leu Asn Asn Lys Leu Ser Asp Ala Leu 
    530                 535                 540                 


Ala Met Val Glu Glu Thr Gln Lys Thr Lys Ala Thr Glu Ser Leu Lys 
545                 550                 555                 560 


Ala Glu Ser Leu Ala Leu Lys Leu Asn Glu Thr Leu Ala Glu Leu Glu 
                565                 570                 575     


Thr Thr Lys Thr Lys Met Ile Met Val Glu Glu Arg Leu Ile Leu Gln 
            580                 585                 590         


Gln Lys Met Val Lys Ala Leu Gln Asp Glu Gln Glu Ser Gln Arg His 
        595                 600                 605             


Gly Phe Glu Glu Glu Ile Met Glu Tyr Lys Glu Gln Ile Lys Gln His 
    610                 615                 620                 


Ala Gln Thr Ile Val Ser Leu Glu Glu Lys Leu Gln Lys Val Thr Gln 
625                 630                 635                 640 


His His Lys Lys Ile Glu Gly Glu Ile Ala Thr Leu Lys Asp Asn Asp 
                645                 650                 655     


Pro Ala Pro Lys Glu Glu Arg Pro Gln Asp Pro Leu Val Ala Pro Met 
            660                 665                 670         


Thr Glu Ser Ser Ala Lys Asp Met Ala Tyr Glu His Leu Ile Asp Asp 
        675                 680                 685             


Leu Leu Ala Ala Gln Lys Glu Ile Leu Ser Gln Gln Glu Val Ile Met 
    690                 695                 700                 


Lys Leu Arg Lys Asp Leu Thr Glu Ala His Ser Arg Met Ser Asp Leu 
705                 710                 715                 720 


Arg Gly Glu Leu Asn Glu Lys Gln Lys Met Glu Leu Glu Gln Asn Val 
                725                 730                 735     


Val Leu Val Gln Gln Gln Ser Lys Glu Leu Ser Val Leu Lys Glu Lys 
            740                 745                 750         


Met Ala Gln Met Ser Ser Leu Val Glu Lys Lys Asp Arg Glu Leu Lys 
        755                 760                 765             


Ala Leu Glu Glu Ala Leu Arg Ala Ser Gln Glu Lys His Arg Leu Gln 
    770                 775                 780                 


Leu Asn Thr Glu Lys Glu Gln Lys Pro Arg Lys Lys Thr Gln Thr Cys 
785                 790                 795                 800 


Asp Thr Ser Val Gln Ile Glu Pro Val His Thr Glu Ala Phe Ser Ser 
                805                 810                 815     


Ser Gln Glu Gln Gln Ser Phe Ser Asp Leu Gly Val Arg Cys Lys Gly 
            820                 825                 830         


Ser Arg His Glu Glu Val Ile Gln Arg Gln Lys Lys Ala Leu Ser Glu 
        835                 840                 845             


Leu Arg Ala Arg Ile Lys Glu Leu Glu Lys Ala Arg Ser Pro Asp His 
    850                 855                 860                 


Lys Asp His Gln Asn Glu Ser Phe Leu Asp Leu Lys Asn Leu Arg Met 
865                 870                 875                 880 


Glu Asn Asn Val Gln Lys Ile Leu Leu Asp Ala Lys Pro Asp Leu Pro 
                885                 890                 895     


Thr Leu Ser Arg Ile Glu Ile Leu Ala Pro Gln Asn Gly Leu Cys Asn 
            900                 905                 910         


Ala Arg Phe Gly Ser Ala Met Glu Lys Ser Gly Lys Met Asp Val Ala 
        915                 920                 925             


Glu Ala Leu Glu Leu Ser Glu Lys Leu Tyr Leu Asp Met Ser Lys Thr 
    930                 935                 940                 


Leu Gly Ser Leu Met Asn Ile Lys Asn Met Ser Gly His Val Ser Met 
945                 950                 955                 960 


Lys Tyr Leu Ser Arg Gln Glu Arg Glu Lys Val Asn Gln Leu Arg Gln 
                965                 970                 975     


Arg Asp Leu Asp Leu Val Phe Asp Lys Ile Thr Gln Leu Lys Asn Gln 
            980                 985                 990         


Leu Gly Arg Lys Glu Glu Leu Leu  Arg Gly Tyr Glu Lys  Asp Val Glu 
        995                 1000                 1005             


Gln Leu  Arg Arg Ser Lys Val  Ser Ile Glu Met Tyr  Gln Ser Gln 
    1010                 1015                 1020             


Val Ala  Lys Leu Glu Asp Asp  Ile Tyr Lys Glu Ala  Glu Glu Lys 
    1025                 1030                 1035             


Ala Leu  Leu Lys Glu Ala Leu  Glu Arg Met Glu His  Gln Leu Cys 
    1040                 1045                 1050             


Gln Glu  Lys Arg Ile Asn Arg  Ala Ile Arg Gln Gln  Lys 
    1055                 1060                 1065     


<210>  5
<211>  1369
<212>  DNA
<213>  Homosapiens

<400>  5
gacatgacag ccctcctcaa atatttaaag ggctgtctca taaaagagaa ataaaacata     60

ctcaatgagc tccaggtgac agaactgagc tcagagacca gaaatcacaa ggagacagat    120

ctccgctgaa tataaagacg agttctataa taattggaac cttccagaga aggcatggac    180

tttgtgcttt aaaagaatcg acagaataat tagagaatag actttaccct gtccttgaag    240

gtgggggata agggggctgg gtaaatatgt attcctgaat gtctgttatt ttgctacttg    300

tttttttgtc taggaattag aattaaaaga gcaaaaagag gacgttttaa ataataaatt    360

aagtgacgca ctggccatgg ttgaagagac tcagaaaaca aaggcaactg aaagtctaaa    420

agcagagagc ctcgccttga aattaaatga aacattagcc gaactggaaa ctaccaagac    480

aaaaatgatc atggtggaag agcggctaat cctgcagcag aagatggtaa aggccctcca    540

ggatgagcag gaatcacaga gacacgggtt tgaagaagag atcatggaat ataaggagca    600

aatcaaacag cacgcccaga caattgtgag cctcgaagag aaactccaga aagtcactca    660

gcaccataaa aaaatagaag gcgagattgc aacattgaag gacaatgacc cagccccaaa    720

ggaggaaagg ccgcaagacc ctctggtggc tcccatgaca gagagcagtg ccaaagacat    780

ggcgtacgaa catctgattg agtctacaaa gaagtctatc ctcaaagaac tgacagtttt    840

cagagaaaca aacgtatgaa tgggaaagat ccagaaagca gcacgtaaag aaggaggcgc    900

cgatgggatg cagtggaggg attcagaagc tcccccaaga ggagaaccac ctgcctgacc    960

cttgcaccaa atcctagtga ccgaagtcta atgtcacagg gtttttaccc caaaaagaca   1020

aggatactca gcctccgcat tgtgaaaagt tcctgactcc tcctcctgtt taaaatctag   1080

aaacggtggt gcccatgact tggagaagac tcagcaccac ccagctctgc tctggtccac   1140

ttccttggcg tgtgaacatg cttgaattct aaggttttat cctcaagttg gaagatttgt   1200

ggttgcagcc aagaacacac tcacgtggac acacacgcat gcatgcacac acagaatata   1260

ctatatctat gtagttattt tcattctgat gatcaccagt ctttttgttt gtttgtttga   1320

catgcaacct gccagtgttt tactttaatt cataataaac acagtacct               1369


<210>  6
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  6

Met Val Glu Glu Thr Gln Lys Thr Lys Ala Thr Glu Ser Leu Lys Ala 
1               5                   10                  15      


Glu Ser Leu Ala Leu Lys Leu Asn Glu Thr Leu Ala Glu Leu Glu Thr 
            20                  25                  30          


Thr Lys Thr Lys Met Ile Met Val Glu Glu Arg Leu Ile Leu Gln Gln 
        35                  40                  45              


Lys Met Val Lys Ala Leu Gln Asp Glu Gln Glu Ser Gln Arg His Gly 
    50                  55                  60                  


Phe Glu Glu Glu Ile Met Glu Tyr Lys Glu Gln Ile Lys Gln His Ala 
65                  70                  75                  80  


Gln Thr Ile Val Ser Leu Glu Glu Lys Leu Gln Lys Val Thr Gln His 
                85                  90                  95      


His Lys Lys Ile Glu Gly Glu Ile Ala Thr Leu Lys Asp Asn Asp Pro 
            100                 105                 110         


Ala Pro Lys Glu Glu Arg Pro Gln Asp Pro Leu Val Ala Pro Met Thr 
        115                 120                 125             


Glu Ser Ser Ala Lys Asp Met Ala Tyr Glu His Leu Ile Glu Ser Thr 
    130                 135                 140                 


Lys Lys Ser Ile Leu Lys Glu Leu Thr Val Phe Arg Glu Thr Asn Val 
145                 150                 155                 160 


<210>  7
<211>  2412
<212>  DNA
<213>  Homosapiens

<400>  7
gagctggaga ctccgcggga gcgcggccgg gaggcttcgc cccggagctg gcccgacgcc     60

tcccgagctg gcagggctct cggcggaggt cggagcgtgg gcttcctcct cccgccaggg    120

aaaacagaga ggatgaaggc ctatctaaag agcgcagaag gcttttttgt cctaaataaa    180

agtaccacaa ttggaaggca tgaaaattca gaccttgttt tacagtctcc tgacatcgac    240

aaccaccatg cactcattga atataacgag gcggagtgca gctttgttct ccaggacttc    300

aattcccgca acggcacgtt tgtcaacgag tgccacattc aaaacgtggc tgtgaagctc    360

atccctggag acatcctgag atttgggtct gcagggctga cctatgaact ggtcattgaa    420

aatccacctc cggtctcttt cccatggatg aggggcccag caccatggcc agggccacag    480

ccacctcgtg ccacacagca gccaaaccag gcccccccac catcacatat ccccttccac    540

caaggtgtcc agccagcacc gatgcaaagg agctggtccc aggcctttcc cagacccacc    600

gtggtcctgc cggcctccca caggcggcct gtgagcgcca acaaggagat gttctcgttc    660

gtggtggacg acgcccgcaa gccacccgtc atcaagcaag gcctcaggga aactcatgat    720

gtcttttgtg ctctctgctg atctcacgcc ttagtgtgga ccaatgccat gaaactgtca    780

gaaaaatcag tggccgaggg gattcctggg gcagttcccc ctgcggagat ttatgtggag    840

gaggacttgg cccagcagga caagatcagt gccctacaga aaggctacag caaggtgctg    900

tgccagaccc tgtcagagcg gaactcagaa atcacatccc tgaagaatga gggcgagaac    960

ttaaagagag acaacgctat cacatcaggg atggtgtcat ctttgcaaaa agacatatta   1020

gcaaaggatg agcaagttca acaactaaag gaagaggtca gtcacctaaa aagtcagaac   1080

aaggacaagg accaccagct ggaagccctt ggctctagat gctcggtgct aaaggaagag   1140

ttaaaacagg aagatgctca cagggagctc agggaagccc aggagaaaga gttaaaactc   1200

tgcaaaaccc aaatccaaga catggagaaa gaaatgaaga agcttagggc agagctgagg   1260

aagagttgta ctgaacaaag cgtgatctct aggactctga gagaaaaaag caagctggag   1320

cacttcagaa gtcaagtcat caaggccacc tatggacggg cgaagccgtt ccgggacaag   1380

cccgtcaccg accaacagtt aatagagaaa attacccagg tcactgagga caacatcaat   1440

tttcagcaga aaaagtggac cctccagaaa gagacccagc tgagcaactc caagcaggag   1500

gagaccaccg agaacatcga gaagctgagg acgtcgctgg acagctgcca ggcttgcatg   1560

aaaatatcct gttgcagcca tgacctgaag aaggaggtcg accttcttca gcacctccag   1620

gtgagcccac ctgtctcggg gctccagaag gtggtgctgg acgtcctgag gcacgcgctg   1680

tcctggctgg aggaggtgga gcagctcctc cgggacctcg ggatcctgcc ctccagcccc   1740

aacaaagggt tctctttgta tctgatatat cttctggaac attataaaaa acttatgagc   1800

caggcccagg aacttcagat caagttcaac agttctcagg aaactcagca gtctttactg   1860

caggaaaagc tgcgggagca tctggcagag aaggagaagc tgaacgagga gaggctagag   1920

caagaggaga agctcaaagc caaaatcagg caactgacgg aagagaaggc ggctttggag   1980

gagtacatta ctcaagagag aaacagagcg aaagagactt tagaggaaga acggaagaga   2040

atgcaagaac tggagagcct cctggcccag cagaagaagg ctttggcgaa aagcattacc   2100

cagtggaaag tactagagaa acctcgtccc accaggcctc atgtgatcct ctaccagaag   2160

ctggagcagc caccttgggg atcagcagac accagcagca ggccaaagga tagtggagtg   2220

gagggacaag aaggcctggg tgagccttct ctgagaatca ctgagctctg aaccatgaat   2280

gaactgccta cctctgtact tcctgttgta taggacaaag aaatccctat ctatttaaac   2340

cactgtagtc aggtctatgt atttgtgctg tggaacaaac cacccaaact gagtgactta   2400

aaatgacaaa ta                                                       2412


<210>  8
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  8

Met Lys Leu Ser Glu Lys Ser Val Ala Glu Gly Ile Pro Gly Ala Val 
1               5                   10                  15      


Pro Pro Ala Glu Ile Tyr Val Glu Glu Asp Leu Ala Gln Gln Asp Lys 
            20                  25                  30          


Ile Ser Ala Leu Gln Lys Gly Tyr Ser Lys Val Leu Cys Gln Thr Leu 
        35                  40                  45              


Ser Glu Arg Asn Ser Glu Ile Thr Ser Leu Lys Asn Glu Gly Glu Asn 
    50                  55                  60                  


Leu Lys Arg Asp Asn Ala Ile Thr Ser Gly Met Val Ser Ser Leu Gln 
65                  70                  75                  80  


Lys Asp Ile Leu Ala Lys Asp Glu Gln Val Gln Gln Leu Lys Glu Glu 
                85                  90                  95      


Val Ser His Leu Lys Ser Gln Asn Lys Asp Lys Asp His Gln Leu Glu 
            100                 105                 110         


Ala Leu Gly Ser Arg Cys Ser Val Leu Lys Glu Glu Leu Lys Gln Glu 
        115                 120                 125             


Asp Ala His Arg Glu Leu Arg Glu Ala Gln Glu Lys Glu Leu Lys Leu 
    130                 135                 140                 


Cys Lys Thr Gln Ile Gln Asp Met Glu Lys Glu Met Lys Lys Leu Arg 
145                 150                 155                 160 


Ala Glu Leu Arg Lys Ser Cys Thr Glu Gln Ser Val Ile Ser Arg Thr 
                165                 170                 175     


Leu Arg Glu Lys Ser Lys Leu Glu His Phe Arg Ser Gln Val Ile Lys 
            180                 185                 190         


Ala Thr Tyr Gly Arg Ala Lys Pro Phe Arg Asp Lys Pro Val Thr Asp 
        195                 200                 205             


Gln Gln Leu Ile Glu Lys Ile Thr Gln Val Thr Glu Asp Asn Ile Asn 
    210                 215                 220                 


Phe Gln Gln Lys Lys Trp Thr Leu Gln Lys Glu Thr Gln Leu Ser Asn 
225                 230                 235                 240 


Ser Lys Gln Glu Glu Thr Thr Glu Asn Ile Glu Lys Leu Arg Thr Ser 
                245                 250                 255     


Leu Asp Ser Cys Gln Ala Cys Met Lys Ile Ser Cys Cys Ser His Asp 
            260                 265                 270         


Leu Lys Lys Glu Val Asp Leu Leu Gln His Leu Gln Val Ser Pro Pro 
        275                 280                 285             


Val Ser Gly Leu Gln Lys Val Val Leu Asp Val Leu Arg His Ala Leu 
    290                 295                 300                 


Ser Trp Leu Glu Glu Val Glu Gln Leu Leu Arg Asp Leu Gly Ile Leu 
305                 310                 315                 320 


Pro Ser Ser Pro Asn Lys Gly Phe Ser Leu Tyr Leu Ile Tyr Leu Leu 
                325                 330                 335     


Glu His Tyr Lys Lys Leu Met Ser Gln Ala Gln Glu Leu Gln Ile Lys 
            340                 345                 350         


Phe Asn Ser Ser Gln Glu Thr Gln Gln Ser Leu Leu Gln Glu Lys Leu 
        355                 360                 365             


Arg Glu His Leu Ala Glu Lys Glu Lys Leu Asn Glu Glu Arg Leu Glu 
    370                 375                 380                 


Gln Glu Glu Lys Leu Lys Ala Lys Ile Arg Gln Leu Thr Glu Glu Lys 
385                 390                 395                 400 


Ala Ala Leu Glu Glu Tyr Ile Thr Gln Glu Arg Asn Arg Ala Lys Glu 
                405                 410                 415     


Thr Leu Glu Glu Glu Arg Lys Arg Met Gln Glu Leu Glu Ser Leu Leu 
            420                 425                 430         


Ala Gln Gln Lys Lys Ala Leu Ala Lys Ser Ile Thr Gln Trp Lys Val 
        435                 440                 445             


Leu Glu Lys Pro Arg Pro Thr Arg Pro His Val Ile Leu Tyr Gln Lys 
    450                 455                 460                 


Leu Glu Gln Pro Pro Trp Gly Ser Ala Asp Thr Ser Ser Arg Pro Lys 
465                 470                 475                 480 


Asp Ser Gly Val Glu Gly Gln Glu Gly Leu Gly Glu Pro Ser Leu Arg 
                485                 490                 495     


Ile Thr Glu Leu 
            500 


<210>  9
<211>  3246
<212>  DNA
<213>  Homosapiens

<400>  9
ccgtcaccga ccaacagtta atagagaaaa ttacccaggt cactgaggac aacatcaatt     60

ttcagcagaa aaagtggacc ctccagaaag agacccagct gagcaactcc aagcaggagg    120

agaccaccga gaacatcgag aagctgagga cgtcgctgga cagctgccag gcttgcatga    180

aaatatcctg ttgcagccat gacctgaaga aggaggtcga ccttcttcag cacctccagg    240

tgagcccacc tgtctcgggg ctccagaagg tggtgctgga cgtcctgagg cacgcgctgt    300

cctggctgga ggaggtggag cagctcctcc gggacctcgg gatcctgccc tccagcccca    360

acaaagggtt ctctttgtat ctgatatatc ttctggaaca ttataaaaaa cttatgagcc    420

aggcccagga acttcagatc aagttcaaca gttctcagga aactcagcag tctttactgc    480

aggaaaagct gcgggagcat ctggcagaga aggagaagct gaacgaggag aggctagagc    540

aagaggagaa gctcaaagcc aaaatcaggc aactgacgga agagaaggcg gtaaggcttt    600

ggaggagtac attactcaag agagaaacag agcgaaagag actttagagg aagaacggaa    660

gagaatgcaa gaactggaga gcctcctggc ccagcagaag aaggctttgg cgaaaagcat    720

tacccaggag aagaacagag tgaaggaagc attagaggaa gagcagacaa gagtccaaga    780

gctggaggaa cgcttggccc gccagaagga ggttttggag agcagcatag cccatgaaaa    840

aagaaaagca aaggaagcct tggagtcgga aaagagaaaa gttcaggatc tggagaacca    900

tttaacccaa cagaaggaga tctcagagag caacattgcg tacgagaaac gcaaagcaaa    960

ggaggccatg gagaaggaaa agaaaaaggt gcaagacctg gagaatcgct taaccaagca   1020

gaaagaggaa ttagaattaa aagagcaaaa agaggacgtt ttaaataata aattaagtga   1080

cgcactggcc atggttgaag agactcagaa aacaaaggca actgaaagtc taaaagcaga   1140

gagcctcgcc ttgaaattaa atgaaacatt agccgaactg gaaactacca agacaaaaat   1200

gatcatggtg gaagagcggc taatcctgca gcagaagatg gtaaaggccc tccaggatga   1260

gcaggaatca cagagacacg ggtttgaaga agagatcatg gaatataagg agcaaatcaa   1320

acagcacgcc cagacaattg tgagcctcga agagaaactc cagaaagtca ctcagcacca   1380

taaaaaaata gaaggcgaga ttgcaacatt gaaggacaat gacccagccc caaaggagga   1440

aaggccgcaa gaccctctgg tggctcccat gacagagagc agtgccaaag acatggcgta   1500

cgaacatctg atagatgact tattggctgc tcagaaggaa attctgtctc agcaggaagt   1560

catcatgaag ttaaggaaag accttaccga agcccacagc agaatgtcgg atttgagagg   1620

ggagctaaac gagaagcaga agatggaact ggagcagaac gtggtgctgg tccagcagca   1680

gagcaaggag ctgagtgtgc tcaaggagaa gatggcccag atgagcagcc tggtagaaaa   1740

gaaagatcgg gagctgaagg cccttgagga ggcactcagg gcttcccaag agaaacacag   1800

actccagctg aacacagaga aggaacagaa gccccggaag aagacccaga cgtgtgacac   1860

ctctgtgcag atagaacccg tccacactga ggccttctcc agcagccaag agcaatcctt   1920

cagcgatcta ggggtcaggt gcaaagggtc ccggcacgag gaggtcattc agcgtcagaa   1980

aaaggcctta tctgaacttc gagcgcgaat taaagaactc gagaaggcgc gctcaccaga   2040

tcataaagac caccagaatg aatcatttct agatttaaag aacctcagaa tggaaaacaa   2100

tgtccagaaa atactactgg atgcaaaacc ggatttgcca actctctcaa gaatagagat   2160

cctagcgcct cagaatggcc tttgcaacgc aaggttcggc tcagccatgg agaagtcagg   2220

gaagatggat gtggctgagg ctttagagct cagtgaaaag ctgtacctgg atatgagcaa   2280

aaccctcgga agtctcatga acatcaagaa tatgtcaggc cacgtgtcca tgaaatacct   2340

ctcccgccag gagagggaga aggtcaacca gcttcgacaa agggacctcg acctggtgtt   2400

tgataagatc acccaactca agaaccagct ggggaggaaa gaggagctgt tgagaggata   2460

tgaaaaggac gttgaacagc tcaggcggag caaagtgtcc attgagatgt accagtcgca   2520

ggtggcaaag ctggaggatg atatctacaa agaggccgaa gagaaggccc tgctgaagga   2580

ggccctggag cgcatggagc accagctgtg ccaggagaag aggatcaaca gggccatccg   2640

gcagcagaag tagatgggag cttccagccc ctgcctcgca gacagatggt gaggatgaaa   2700

gaatgcaggc atccctcgct atctgctgtc cactctcgct gtcgtcatac ctcaggagcc   2760

aagtgctttt ggatggtgag ggtgcttgtc ccgtctctga agcacctgcc cagggcctgg   2820

caccagccgg cggacactgc cttccccatg ctgcccatga cccatgctgc ccgtgaccca   2880

tgcaggtggt ctcctgggaa agtgtagagg agcacgaact gagaaacgca aaagaatcga   2940

caccttgcaa ctgtgccttc aaagagaaag acaggcagag acgagtattt gtagagatgg   3000

tgaagaacag gatgcagaac tcaaattccc aggttggaac cagaaaagcc tccctaaaga   3060

tggaccaaga aagagagatg ctgaggaaag agacctccag caagtccagc cagagccttt   3120

tgcattctaa gcccagtgga aagtactaga gaaacctcgt cccaccaggc ctcatgtgat   3180

cctctgtgag ttcatgtgac tcttctgtgt catctgtgtc aaaatactga gttgcttttg   3240

taagtc                                                              3246


<210>  10
<211>  662
<212>  PRT
<213>  Homosapiens

<400>  10

Met Gln Glu Leu Glu Ser Leu Leu Ala Gln Gln Lys Lys Ala Leu Ala 
1               5                   10                  15      


Lys Ser Ile Thr Gln Glu Lys Asn Arg Val Lys Glu Ala Leu Glu Glu 
            20                  25                  30          


Glu Gln Thr Arg Val Gln Glu Leu Glu Glu Arg Leu Ala Arg Gln Lys 
        35                  40                  45              


Glu Val Leu Glu Ser Ser Ile Ala His Glu Lys Arg Lys Ala Lys Glu 
    50                  55                  60                  


Ala Leu Glu Ser Glu Lys Arg Lys Val Gln Asp Leu Glu Asn His Leu 
65                  70                  75                  80  


Thr Gln Gln Lys Glu Ile Ser Glu Ser Asn Ile Ala Tyr Glu Lys Arg 
                85                  90                  95      


Lys Ala Lys Glu Ala Met Glu Lys Glu Lys Lys Lys Val Gln Asp Leu 
            100                 105                 110         


Glu Asn Arg Leu Thr Lys Gln Lys Glu Glu Leu Glu Leu Lys Glu Gln 
        115                 120                 125             


Lys Glu Asp Val Leu Asn Asn Lys Leu Ser Asp Ala Leu Ala Met Val 
    130                 135                 140                 


Glu Glu Thr Gln Lys Thr Lys Ala Thr Glu Ser Leu Lys Ala Glu Ser 
145                 150                 155                 160 


Leu Ala Leu Lys Leu Asn Glu Thr Leu Ala Glu Leu Glu Thr Thr Lys 
                165                 170                 175     


Thr Lys Met Ile Met Val Glu Glu Arg Leu Ile Leu Gln Gln Lys Met 
            180                 185                 190         


Val Lys Ala Leu Gln Asp Glu Gln Glu Ser Gln Arg His Gly Phe Glu 
        195                 200                 205             


Glu Glu Ile Met Glu Tyr Lys Glu Gln Ile Lys Gln His Ala Gln Thr 
    210                 215                 220                 


Ile Val Ser Leu Glu Glu Lys Leu Gln Lys Val Thr Gln His His Lys 
225                 230                 235                 240 


Lys Ile Glu Gly Glu Ile Ala Thr Leu Lys Asp Asn Asp Pro Ala Pro 
                245                 250                 255     


Lys Glu Glu Arg Pro Gln Asp Pro Leu Val Ala Pro Met Thr Glu Ser 
            260                 265                 270         


Ser Ala Lys Asp Met Ala Tyr Glu His Leu Ile Asp Asp Leu Leu Ala 
        275                 280                 285             


Ala Gln Lys Glu Ile Leu Ser Gln Gln Glu Val Ile Met Lys Leu Arg 
    290                 295                 300                 


Lys Asp Leu Thr Glu Ala His Ser Arg Met Ser Asp Leu Arg Gly Glu 
305                 310                 315                 320 


Leu Asn Glu Lys Gln Lys Met Glu Leu Glu Gln Asn Val Val Leu Val 
                325                 330                 335     


Gln Gln Gln Ser Lys Glu Leu Ser Val Leu Lys Glu Lys Met Ala Gln 
            340                 345                 350         


Met Ser Ser Leu Val Glu Lys Lys Asp Arg Glu Leu Lys Ala Leu Glu 
        355                 360                 365             


Glu Ala Leu Arg Ala Ser Gln Glu Lys His Arg Leu Gln Leu Asn Thr 
    370                 375                 380                 


Glu Lys Glu Gln Lys Pro Arg Lys Lys Thr Gln Thr Cys Asp Thr Ser 
385                 390                 395                 400 


Val Gln Ile Glu Pro Val His Thr Glu Ala Phe Ser Ser Ser Gln Glu 
                405                 410                 415     


Gln Ser Phe Ser Asp Leu Gly Val Arg Cys Lys Gly Ser Arg His Glu 
            420                 425                 430         


Glu Val Ile Gln Arg Gln Lys Lys Ala Leu Ser Glu Leu Arg Ala Arg 
        435                 440                 445             


Ile Lys Glu Leu Glu Lys Ala Arg Ser Pro Asp His Lys Asp His Gln 
    450                 455                 460                 


Asn Glu Ser Phe Leu Asp Leu Lys Asn Leu Arg Met Glu Asn Asn Val 
465                 470                 475                 480 


Gln Lys Ile Leu Leu Asp Ala Lys Pro Asp Leu Pro Thr Leu Ser Arg 
                485                 490                 495     


Ile Glu Ile Leu Ala Pro Gln Asn Gly Leu Cys Asn Ala Arg Phe Gly 
            500                 505                 510         


Ser Ala Met Glu Lys Ser Gly Lys Met Asp Val Ala Glu Ala Leu Glu 
        515                 520                 525             


Leu Ser Glu Lys Leu Tyr Leu Asp Met Ser Lys Thr Leu Gly Ser Leu 
    530                 535                 540                 


Met Asn Ile Lys Asn Met Ser Gly His Val Ser Met Lys Tyr Leu Ser 
545                 550                 555                 560 


Arg Gln Glu Arg Glu Lys Val Asn Gln Leu Arg Gln Arg Asp Leu Asp 
                565                 570                 575     


Leu Val Phe Asp Lys Ile Thr Gln Leu Lys Asn Gln Leu Gly Arg Lys 
            580                 585                 590         


Glu Glu Leu Leu Arg Gly Tyr Glu Lys Asp Val Glu Gln Leu Arg Arg 
        595                 600                 605             


Ser Lys Val Ser Ile Glu Met Tyr Gln Ser Gln Val Ala Lys Leu Glu 
    610                 615                 620                 


Asp Asp Ile Tyr Lys Glu Ala Glu Glu Lys Ala Leu Leu Lys Glu Ala 
625                 630                 635                 640 


Leu Glu Arg Met Glu His Gln Leu Cys Gln Glu Lys Arg Ile Asn Arg 
                645                 650                 655     


Ala Ile Arg Gln Gln Lys 
            660         


<210>  11
<211>  3981
<212>  DNA
<213>  Homosapiens

<400>  11
ccatgtaaga agtgcttttc gcctcccacc atgattctga ggcctccccg gccatgtgga     60

actatcagtg ccctacagaa aggctacagc aaggtgctgt gccagaccct gtcagagcgg    120

aactcagaaa tcacatccct gaagaatgag ggcgagaact taaagagaga caacgctatc    180

acatcaggga tggtgtcatc tttgcaaaaa gacatattag caaaggatga gcaagttcaa    240

caactaaagg aagaggtcag tcacctaaaa agtcagaaca aggacaagga ccaccagctg    300

gaagcccttg gctctagatg ctcggtgcta aaggaagagt taaaacagga agatgctcac    360

agggagctca gggaagccca ggagaaagag ttaaaactct gcaaaaccca aatccaagac    420

atggagaaag aaatgaagaa gcttagggca gagctgagga agagttgtac tgaacaaagc    480

gtgatctcta ggactctgag agaaaaaagc aaggttgaag agaagcttca ggaggattcc    540

agaaggaaat tgcttcagct gcaagaaatg gggaacagag agagcgtcat taaaatcaat    600

ttggagaggg cagtaggtca gctggagcac ttcagaagtc aagtcatcaa ggccacctat    660

ggacgggcga agccgttccg ggacaagccc gtcaccgacc aacagttaat agagaaaatt    720

acccaggtca ctgaggacaa catcaatttt cagcagaaaa agtggaccct ccagaaagag    780

acccagctga gcaactccaa gcaggaggag accaccgaga acatcgagaa gctgaggacg    840

tcgctggaca gctgccaggc ttgcatgaaa atatcctgtt gcagccatga cctgaagaag    900

gaggtcgacc ttcttcagca cctccaggtg agcccacctg tctcggggct ccagaaggtg    960

gtgctggacg tcctgaggca cgcgctgtcc tggctggagg aggtggagca gctcctccgg   1020

gacctcggga tcctgccctc cagccccaac aaagggttct ctttgtatct gatatatctt   1080

ctggaacatt ataaaaaact tatgagccag gcccaggaac ttcagatcaa gttcaacagt   1140

tctcaggaaa ctcagcagtc tttactgcag gaaaagctgc gggagcatct ggcagagaag   1200

gagaagctga acgaggagag gctagagcaa gaggagaagc tcaaagccaa aatcaggcaa   1260

ctgacggaag agaaggcggc tttggaggag tacattactc aagagagaaa cagagcgaaa   1320

gagactttag aggaagaacg gaagagaatg caagaactgg agagcctcct ggcccagcag   1380

aagaaggctt tggcgaaaag cattacccag gagaagaaca gagtgaagga agcattagag   1440

gaagagcaga caagagtcca agagctggag gaacgcttgg cccgccagaa ggagatctca   1500

gagagcaaca ttgcgtacga gaaacgcaaa gcaaaggagg ccatggagaa ggaaaagaaa   1560

aaggtgcaag acctggagaa tcgcttaacc aagcagaaag aggaattaga attaaaagag   1620

caaaaagagg acgttttaaa taataaatta agtgacgcac tggccatggt tgaagagact   1680

cagaaaacaa aggcaactga aagtctaaaa gcagagagcc tcgccttgaa attaaatgaa   1740

acattagccg aactggaaac taccaagaca aaaatgatca tggtggaaga gcggctaatc   1800

ctgcagcaga agatggtaaa ggccctccag gatgagcagg aatcacagag acacgggttt   1860

gaagaagaga tcatggaata taaggagcaa atcaaacagc acgcccagac aattgtgagc   1920

ctcgaagaga aactccagaa agtcactcag caccataaaa aaatagaagg cgagattgca   1980

acattgaagg acaatgaccc agccccaaag gaggaaaggc cgcaagaccc tctggtggct   2040

cccatgacag agagcagtgc caaagacatg gcgtacgaac atctgataga tgacttattg   2100

gctgctcaga aggaaattct gtctcagcag gaagtcatca tgaagttaag gaaagacctt   2160

accgaagccc acagcagaat gtcggatttg agaggggagc taaacgagaa gcagaagatg   2220

gaactggagc agaacgtggt gctggtccag cagcagagca aggagctgag tgtgctcaag   2280

gagaagatgg cccagatgag cagcctggta gaaaagaaag atcgggagct gaaggccctt   2340

gaggaggcac tcagggcttc ccaagagaaa cacagactcc agctgaacac agagaaggaa   2400

cagaagcccc ggaagaagac ccagacgtgt gacacctctg tgcagataga acccgtccac   2460

actgaggcct tctccagcag ccaagagcag caatccttca gcgatctagg ggtcaggtgc   2520

aaagggtccc ggcacgagga ggtcattcag cgtcagaaaa aggccttatc tgaacttcga   2580

gcgcgaatta aagaactcga gaaggcgcgc tcaccagatc ataaagacca ccagaatgaa   2640

tcatttctag atttaaagaa cctcagaatg gaaaacaatg tccagaaaat actactggat   2700

gcaaaaccgg atttgccaac tctctcaaga atagagatcc tagcgcctca gaatggcctt   2760

tgcaacgcaa ggttcggctc agccatggag aagtcaggga agatggatgt ggctgaggct   2820

ttagagctca gtgaaaagct gtacctggat atgagcaaaa ccctcggaag tctcatgaac   2880

atcaagaata tgtcaggcca cgtgtccatg aaatacctct cccgccagga gagggagaag   2940

gtcaaccagc ttcgacaaag ggacctcgac ctggtgtttg ataagatcac ccaactcaag   3000

aaccagctgg ggaggaaaga ggagctgttg agaggatatg aaaaggacgt tgaacagctc   3060

aggcggagca aagtgtccat tgagatgtac cagtcgcagg tggcaaagct ggaggatgat   3120

atctacaaag aggccgaaga gaaggccctg ctgaaggagg ccctggagcg catggagcac   3180

cagctgtgcc aggagaagag gatcaacagg gccatccggc agcagaagga aagtgtagag   3240

gagcacgaac tgagaaacgc aaaagaatcg acaccttgca actgtgcctt caaagagaaa   3300

gacaggcagg ccctgcccca cctgcctgca gtttgaacgg atgacctaag agacaagcac   3360

gcgtccagcc ccgtctgtcc attaagagtc ttgctctatt gcccaggcta gagtgcagtg   3420

gtgcaatttc ggctcactgc aacctccacc tcccaggttc aagcgattct cctgcctcag   3480

cctcccgagt agctgggact acaggttgga accagaaaag cctccctaaa gatggaccaa   3540

gaaagagaga tgctgaggaa agagacctcc agcaagtcca gccagagcct tttgcattct   3600

aagcccagtg gaaagtacta gagaaacctc gtcccaccag gcctcatgtg atcctctcta   3660

ggacgggcca tgttggacca atctggctaa tgacatataa ggaaaagctc ctgtggaggg   3720

cttcccttcc agcttctcta ggtgaaagca ttcacccttg gtacctttgt cttgtctcct   3780

ttctcactcc tggagctcag accagaagct ggagcagcca ccttggggat cagcagacac   3840

cagcagcagg ccaaaggata gtggagtgga gggacaagaa ggcctgggtg agccttctct   3900

gagaatcact gagctctgaa ccatgaatga actgcctacc tctgtacttc ctgttgtata   3960

ggacaaagaa atccctatct a                                             3981


<210>  12
<211>  1101
<212>  PRT
<213>  Homosapiens

<400>  12

Met Ile Leu Arg Pro Pro Arg Pro Cys Gly Thr Ile Ser Ala Leu Gln 
1               5                   10                  15      


Lys Gly Tyr Ser Lys Val Leu Cys Gln Thr Leu Ser Glu Arg Asn Ser 
            20                  25                  30          


Glu Ile Thr Ser Leu Lys Asn Glu Gly Glu Asn Leu Lys Arg Asp Asn 
        35                  40                  45              


Ala Ile Thr Ser Gly Met Val Ser Ser Leu Gln Lys Asp Ile Leu Ala 
    50                  55                  60                  


Lys Asp Glu Gln Val Gln Gln Leu Lys Glu Glu Val Ser His Leu Lys 
65                  70                  75                  80  


Ser Gln Asn Lys Asp Lys Asp His Gln Leu Glu Ala Leu Gly Ser Arg 
                85                  90                  95      


Cys Ser Val Leu Lys Glu Glu Leu Lys Gln Glu Asp Ala His Arg Glu 
            100                 105                 110         


Leu Arg Glu Ala Gln Glu Lys Glu Leu Lys Leu Cys Lys Thr Gln Ile 
        115                 120                 125             


Gln Asp Met Glu Lys Glu Met Lys Lys Leu Arg Ala Glu Leu Arg Lys 
    130                 135                 140                 


Ser Cys Thr Glu Gln Ser Val Ile Ser Arg Thr Leu Arg Glu Lys Ser 
145                 150                 155                 160 


Lys Val Glu Glu Lys Leu Gln Glu Asp Ser Arg Arg Lys Leu Leu Gln 
                165                 170                 175     


Leu Gln Glu Met Gly Asn Arg Glu Ser Val Ile Lys Ile Asn Leu Glu 
            180                 185                 190         


Arg Ala Val Gly Gln Leu Glu His Phe Arg Ser Gln Val Ile Lys Ala 
        195                 200                 205             


Thr Tyr Gly Arg Ala Lys Pro Phe Arg Asp Lys Pro Val Thr Asp Gln 
    210                 215                 220                 


Gln Leu Ile Glu Lys Ile Thr Gln Val Thr Glu Asp Asn Ile Asn Phe 
225                 230                 235                 240 


Gln Gln Lys Lys Trp Thr Leu Gln Lys Glu Thr Gln Leu Ser Asn Ser 
                245                 250                 255     


Lys Gln Glu Glu Thr Thr Glu Asn Ile Glu Lys Leu Arg Thr Ser Leu 
            260                 265                 270         


Asp Ser Cys Gln Ala Cys Met Lys Ile Ser Cys Cys Ser His Asp Leu 
        275                 280                 285             


Lys Lys Glu Val Asp Leu Leu Gln His Leu Gln Val Ser Pro Pro Val 
    290                 295                 300                 


Ser Gly Leu Gln Lys Val Val Leu Asp Val Leu Arg His Ala Leu Ser 
305                 310                 315                 320 


Trp Leu Glu Glu Val Glu Gln Leu Leu Arg Asp Leu Gly Ile Leu Pro 
                325                 330                 335     


Ser Ser Pro Asn Lys Gly Phe Ser Leu Tyr Leu Ile Tyr Leu Leu Glu 
            340                 345                 350         


His Tyr Lys Lys Leu Met Ser Gln Ala Gln Glu Leu Gln Ile Lys Phe 
        355                 360                 365             


Asn Ser Ser Gln Glu Thr Gln Gln Ser Leu Leu Gln Glu Lys Leu Arg 
    370                 375                 380                 


Glu His Leu Ala Glu Lys Glu Lys Leu Asn Glu Glu Arg Leu Glu Gln 
385                 390                 395                 400 


Glu Glu Lys Leu Lys Ala Lys Ile Arg Gln Leu Thr Glu Glu Lys Ala 
                405                 410                 415     


Ala Leu Glu Glu Tyr Ile Thr Gln Glu Arg Asn Arg Ala Lys Glu Thr 
            420                 425                 430         


Leu Glu Glu Glu Arg Lys Arg Met Gln Glu Leu Glu Ser Leu Leu Ala 
        435                 440                 445             


Gln Gln Lys Lys Ala Leu Ala Lys Ser Ile Thr Gln Glu Lys Asn Arg 
    450                 455                 460                 


Val Lys Glu Ala Leu Glu Glu Glu Gln Thr Arg Val Gln Glu Leu Glu 
465                 470                 475                 480 


Glu Arg Leu Ala Arg Gln Lys Glu Ile Ser Glu Ser Asn Ile Ala Tyr 
                485                 490                 495     


Glu Lys Arg Lys Ala Lys Glu Ala Met Glu Lys Glu Lys Lys Lys Val 
            500                 505                 510         


Gln Asp Leu Glu Asn Arg Leu Thr Lys Gln Lys Glu Glu Leu Glu Leu 
        515                 520                 525             


Lys Glu Gln Lys Glu Asp Val Leu Asn Asn Lys Leu Ser Asp Ala Leu 
    530                 535                 540                 


Ala Met Val Glu Glu Thr Gln Lys Thr Lys Ala Thr Glu Ser Leu Lys 
545                 550                 555                 560 


Ala Glu Ser Leu Ala Leu Lys Leu Asn Glu Thr Leu Ala Glu Leu Glu 
                565                 570                 575     


Thr Thr Lys Thr Lys Met Ile Met Val Glu Glu Arg Leu Ile Leu Gln 
            580                 585                 590         


Gln Lys Met Val Lys Ala Leu Gln Asp Glu Gln Glu Ser Gln Arg His 
        595                 600                 605             


Gly Phe Glu Glu Glu Ile Met Glu Tyr Lys Glu Gln Ile Lys Gln His 
    610                 615                 620                 


Ala Gln Thr Ile Val Ser Leu Glu Glu Lys Leu Gln Lys Val Thr Gln 
625                 630                 635                 640 


His His Lys Lys Ile Glu Gly Glu Ile Ala Thr Leu Lys Asp Asn Asp 
                645                 650                 655     


Pro Ala Pro Lys Glu Glu Arg Pro Gln Asp Pro Leu Val Ala Pro Met 
            660                 665                 670         


Thr Glu Ser Ser Ala Lys Asp Met Ala Tyr Glu His Leu Ile Asp Asp 
        675                 680                 685             


Leu Leu Ala Ala Gln Lys Glu Ile Leu Ser Gln Gln Glu Val Ile Met 
    690                 695                 700                 


Lys Leu Arg Lys Asp Leu Thr Glu Ala His Ser Arg Met Ser Asp Leu 
705                 710                 715                 720 


Arg Gly Glu Leu Asn Glu Lys Gln Lys Met Glu Leu Glu Gln Asn Val 
                725                 730                 735     


Val Leu Val Gln Gln Gln Ser Lys Glu Leu Ser Val Leu Lys Glu Lys 
            740                 745                 750         


Met Ala Gln Met Ser Ser Leu Val Glu Lys Lys Asp Arg Glu Leu Lys 
        755                 760                 765             


Ala Leu Glu Glu Ala Leu Arg Ala Ser Gln Glu Lys His Arg Leu Gln 
    770                 775                 780                 


Leu Asn Thr Glu Lys Glu Gln Lys Pro Arg Lys Lys Thr Gln Thr Cys 
785                 790                 795                 800 


Asp Thr Ser Val Gln Ile Glu Pro Val His Thr Glu Ala Phe Ser Ser 
                805                 810                 815     


Ser Gln Glu Gln Gln Ser Phe Ser Asp Leu Gly Val Arg Cys Lys Gly 
            820                 825                 830         


Ser Arg His Glu Glu Val Ile Gln Arg Gln Lys Lys Ala Leu Ser Glu 
        835                 840                 845             


Leu Arg Ala Arg Ile Lys Glu Leu Glu Lys Ala Arg Ser Pro Asp His 
    850                 855                 860                 


Lys Asp His Gln Asn Glu Ser Phe Leu Asp Leu Lys Asn Leu Arg Met 
865                 870                 875                 880 


Glu Asn Asn Val Gln Lys Ile Leu Leu Asp Ala Lys Pro Asp Leu Pro 
                885                 890                 895     


Thr Leu Ser Arg Ile Glu Ile Leu Ala Pro Gln Asn Gly Leu Cys Asn 
            900                 905                 910         


Ala Arg Phe Gly Ser Ala Met Glu Lys Ser Gly Lys Met Asp Val Ala 
        915                 920                 925             


Glu Ala Leu Glu Leu Ser Glu Lys Leu Tyr Leu Asp Met Ser Lys Thr 
    930                 935                 940                 


Leu Gly Ser Leu Met Asn Ile Lys Asn Met Ser Gly His Val Ser Met 
945                 950                 955                 960 


Lys Tyr Leu Ser Arg Gln Glu Arg Glu Lys Val Asn Gln Leu Arg Gln 
                965                 970                 975     


Arg Asp Leu Asp Leu Val Phe Asp Lys Ile Thr Gln Leu Lys Asn Gln 
            980                 985                 990         


Leu Gly Arg Lys Glu Glu Leu Leu  Arg Gly Tyr Glu Lys  Asp Val Glu 
        995                 1000                 1005             


Gln Leu  Arg Arg Ser Lys Val  Ser Ile Glu Met Tyr  Gln Ser Gln 
    1010                 1015                 1020             


Val Ala  Lys Leu Glu Asp Asp  Ile Tyr Lys Glu Ala  Glu Glu Lys 
    1025                 1030                 1035             


Ala Leu  Leu Lys Glu Ala Leu  Glu Arg Met Glu His  Gln Leu Cys 
    1040                 1045                 1050             


Gln Glu  Lys Arg Ile Asn Arg  Ala Ile Arg Gln Gln  Lys Glu Ser 
    1055                 1060                 1065             


Val Glu  Glu His Glu Leu Arg  Asn Ala Lys Glu Ser  Thr Pro Cys 
    1070                 1075                 1080             


Asn Cys  Ala Phe Lys Glu Lys  Asp Arg Gln Ala Leu  Pro His Leu 
    1085                 1090                 1095             


Pro Ala  Val 
    1100     


<210>  13
<211>  3577
<212>  DNA
<213>  Homosapiens

<400>  13
ccatgtaaga agtgcttttc gcctcccacc atgattctga ggcctccccg gccatgtgga     60

actatcagtg ccctacagaa aggctacagc aaggtgctgt gccagaccct gtcagagcgg    120

aactcagaaa tcacatccct gaagaatgag ggcgagaact taaagagaga caacgctatc    180

acatcaggga tggtgtcatc tttgcaaaaa gacatattag caaaggatga gcaagttcaa    240

caactaaagg aagaggtcag tcacctaaaa agtcagaaca aggacaagga ccaccagctg    300

gaagcccttg gctctagatg ctcggtgcta aaggaagagt taaaacagga agatgctcac    360

agggagctca gggaagccca ggagaaagag ttaaaactct gcaaaaccca aatccaagac    420

atggagaaag aaatgaagaa gcttagggca gagctgagga agagttgtac tgaacaaagc    480

gtgatctcta ggactctgag agaaaaaagc aaggttgaag agaagcttca ggaggattcc    540

agaaggaaat tgcttcagct gcaagaaatg gggaacagag agagcgtcat taaaatcaat    600

ttggagaggg cagtaggtca gctggagcac ttcagaagtc aagtcatcaa ggccacctat    660

ggacgggcga agccgttccg ggacaagccc gtcaccgacc aacagttaat agagaaaatt    720

acccaggtca ctgaggacaa catcaatttt cagcagaaaa agtggaccct ccagaaagag    780

acccagctga gcaactccaa gcaggaggag accaccgaga acatcgagaa gctgaggacg    840

tcgctggaca gctgccaggc ttgcatgaaa atatcctgtt gcagccatga cctgaagaag    900

gaggtcgacc ttcttcagca cctccaggtg agcccacctg tctcggggct ccagaaggtg    960

gtgctggacg tcctgaggca cgcgctgtcc tggctggagg aggtggagca gctcctccgg   1020

gacctcggga tcctgccctc cagccccaac aaagggttct ctttgtatct gatatatctt   1080

ctggaacatt ataaaaaact tatgagccag gcccaggaac ttcagatcaa gttcaacagt   1140

tctcaggaaa ctcagcagtc tttactgcag gaaaagctgc gggagcatct ggcagagaag   1200

gagaagctga acgaggagag gctagagcaa gaggagaagc tcaaagccaa aatcaggcaa   1260

ctgacggaag agaaggcggc tttggaggag tacattactc aagagagaaa cagagcgaaa   1320

gagactttag aggaagaacg gaagagaatg caagaactgg agagcctcct ggcccagcag   1380

aagaaggctt tggcgaaaag cattacccag gagaagaaca gagtgaagga agcattagag   1440

gaagagcaga caagagtcca agagctggag gaacgcttgg cccgccagaa ggagatctca   1500

gagagcaaca ttgcgtacga gaaacgcaaa gcaaaggagg ccatggagaa ggaaaagaaa   1560

aaggtgcaag acctggagaa tcgcttaacc aagcagaaag aggaattaga attaaaagag   1620

caaaaagagg acgttttaaa taataaatta agtgacgcac tggccatggt tgaagagact   1680

cagaaaacaa aggcaactga aagtctaaaa gcagagagcc tcgccttgaa attaaatgaa   1740

acattagccg aactggaaac taccaagaca aaaatgatca tggtggaaga gcggctaatc   1800

ctgcagcaga agatggtaaa ggccctccag gatgagcagg aatcacagag acacgggttt   1860

gaagaagaga tcatggaata taaggagcaa atcaaacagc acgcccagac aattgtgagc   1920

ctcgaagaga aactccagaa agtcactcag caccataaaa aaatagaagg cgagattgca   1980

acattgaagg acaatgaccc agccccaaag gaggaaaggc cgcaagaccc tctggtggct   2040

cccatgacag agagcagtgc caaagacatg gcgtacgaac atctgataga tgacttattg   2100

gctgctcaga aggaaattct gtctcagcag gaagtcatca tgaagttaag gaaagacctt   2160

accgaagccc acagcagaat gtcggatttg agaggggagc taaacgagaa gcagaagatg   2220

gaactggagc agaacgtggt gctggtccag cagcagagca aggagctgag tgtgctcaag   2280

gagaagatgg cccagatgag cagcctggta gaaaagaaag atcgggagct gaaggccctt   2340

gaggaggcac tcagggcttc ccaagagaaa cacagactcc agctgaacac agagaaggaa   2400

cagaagcccc ggaagaagac ccagacgtgt gacacctctg tgcagataga acccgtccac   2460

actgaggcct tctccagcag ccaagagcag caatccttca gcgatctagg ggtcaggtgc   2520

aaagggtccc ggcacgagga ggtcattcag cgtcagaaaa aggccttatc tgaacttcga   2580

gcgcgaatta aagaactcga gaaggcgcgc tcaccagatc ataaagacca ccagaatgaa   2640

tcatttctag atttaaagaa cctcagaatg gaaaacaatg tccagaaaat actactggat   2700

gcaaaaccgg atttgccaac tctctcaaga atagagatcc tagcgcctca gaatggcctt   2760

tgcaacgcaa ggttcggctc agccatggag aagtcaggga agatggatgt ggctgaggct   2820

ttagagctca gtgaaaagct gtacctggat atgagcaaaa ccctcggaag tctcatgaac   2880

atcaagaata tgtcaggcca cgtgtccatg aaatacctct cccgccagga gagggagaag   2940

gtcaaccagc ttcgacaaag ggacctcgac ctggtgtttg ataagatcac ccaactcaag   3000

aaccagctgg ggaggaaaga ggagctgttg agaggatatg aaaaggacgt tgaacagctc   3060

aggcggagca aagtgtccat tgagatgtac cagtcgcagg tggcaaagct ggaggatgat   3120

atctacaaag aggccgaaga gaaggccctg ctgaaggagg ccctggagcg catggagcac   3180

cagctgtgcc aggagaagag gatcaacagg gccatccggc agcagaagat gggagcttcc   3240

agcccctgcc tcgcagacag atggtgagga tgaaagaatg caggcatccc tcgctatctg   3300

ctgtccactc tcgctgtcgt catacctcag gagccaagtg cttttggatg gttggaacca   3360

gaaaagcctc cctaaagatg gaccaagaaa gagagatgct gaggaaagag acctccagca   3420

agtccagcca gagccttttg cattctaagc ccagtggaaa gtactagaga aacctcgtcc   3480

caccaggcct catgtgatcc tctgtgagtt catgtgactc ttctgtgtca tctgtgtcaa   3540

aatactgagt tgcttttgta agtctttaaa gattgtt                            3577


<210>  14
<211>  1078
<212>  PRT
<213>  Homosapiens

<400>  14

Met Ile Leu Arg Pro Pro Arg Pro Cys Gly Thr Ile Ser Ala Leu Gln 
1               5                   10                  15      


Lys Gly Tyr Ser Lys Val Leu Cys Gln Thr Leu Ser Glu Arg Asn Ser 
            20                  25                  30          


Glu Ile Thr Ser Leu Lys Asn Glu Gly Glu Asn Leu Lys Arg Asp Asn 
        35                  40                  45              


Ala Ile Thr Ser Gly Met Val Ser Ser Leu Gln Lys Asp Ile Leu Ala 
    50                  55                  60                  


Lys Asp Glu Gln Val Gln Gln Leu Lys Glu Glu Val Ser His Leu Lys 
65                  70                  75                  80  


Ser Gln Asn Lys Asp Lys Asp His Gln Leu Glu Ala Leu Gly Ser Arg 
                85                  90                  95      


Cys Ser Val Leu Lys Glu Glu Leu Lys Gln Glu Asp Ala His Arg Glu 
            100                 105                 110         


Leu Arg Glu Ala Gln Glu Lys Glu Leu Lys Leu Cys Lys Thr Gln Ile 
        115                 120                 125             


Gln Asp Met Glu Lys Glu Met Lys Lys Leu Arg Ala Glu Leu Arg Lys 
    130                 135                 140                 


Ser Cys Thr Glu Gln Ser Val Ile Ser Arg Thr Leu Arg Glu Lys Ser 
145                 150                 155                 160 


Lys Val Glu Glu Lys Leu Gln Glu Asp Ser Arg Arg Lys Leu Leu Gln 
                165                 170                 175     


Leu Gln Glu Met Gly Asn Arg Glu Ser Val Ile Lys Ile Asn Leu Glu 
            180                 185                 190         


Arg Ala Val Gly Gln Leu Glu His Phe Arg Ser Gln Val Ile Lys Ala 
        195                 200                 205             


Thr Tyr Gly Arg Ala Lys Pro Phe Arg Asp Lys Pro Val Thr Asp Gln 
    210                 215                 220                 


Gln Leu Ile Glu Lys Ile Thr Gln Val Thr Glu Asp Asn Ile Asn Phe 
225                 230                 235                 240 


Gln Gln Lys Lys Trp Thr Leu Gln Lys Glu Thr Gln Leu Ser Asn Ser 
                245                 250                 255     


Lys Gln Glu Glu Thr Thr Glu Asn Ile Glu Lys Leu Arg Thr Ser Leu 
            260                 265                 270         


Asp Ser Cys Gln Ala Cys Met Lys Ile Ser Cys Cys Ser His Asp Leu 
        275                 280                 285             


Lys Lys Glu Val Asp Leu Leu Gln His Leu Gln Val Ser Pro Pro Val 
    290                 295                 300                 


Ser Gly Leu Gln Lys Val Val Leu Asp Val Leu Arg His Ala Leu Ser 
305                 310                 315                 320 


Trp Leu Glu Glu Val Glu Gln Leu Leu Arg Asp Leu Gly Ile Leu Pro 
                325                 330                 335     


Ser Ser Pro Asn Lys Gly Phe Ser Leu Tyr Leu Ile Tyr Leu Leu Glu 
            340                 345                 350         


His Tyr Lys Lys Leu Met Ser Gln Ala Gln Glu Leu Gln Ile Lys Phe 
        355                 360                 365             


Asn Ser Ser Gln Glu Thr Gln Gln Ser Leu Leu Gln Glu Lys Leu Arg 
    370                 375                 380                 


Glu His Leu Ala Glu Lys Glu Lys Leu Asn Glu Glu Arg Leu Glu Gln 
385                 390                 395                 400 


Glu Glu Lys Leu Lys Ala Lys Ile Arg Gln Leu Thr Glu Glu Lys Ala 
                405                 410                 415     


Ala Leu Glu Glu Tyr Ile Thr Gln Glu Arg Asn Arg Ala Lys Glu Thr 
            420                 425                 430         


Leu Glu Glu Glu Arg Lys Arg Met Gln Glu Leu Glu Ser Leu Leu Ala 
        435                 440                 445             


Gln Gln Lys Lys Ala Leu Ala Lys Ser Ile Thr Gln Glu Lys Asn Arg 
    450                 455                 460                 


Val Lys Glu Ala Leu Glu Glu Glu Gln Thr Arg Val Gln Glu Leu Glu 
465                 470                 475                 480 


Glu Arg Leu Ala Arg Gln Lys Glu Ile Ser Glu Ser Asn Ile Ala Tyr 
                485                 490                 495     


Glu Lys Arg Lys Ala Lys Glu Ala Met Glu Lys Glu Lys Lys Lys Val 
            500                 505                 510         


Gln Asp Leu Glu Asn Arg Leu Thr Lys Gln Lys Glu Glu Leu Glu Leu 
        515                 520                 525             


Lys Glu Gln Lys Glu Asp Val Leu Asn Asn Lys Leu Ser Asp Ala Leu 
    530                 535                 540                 


Ala Met Val Glu Glu Thr Gln Lys Thr Lys Ala Thr Glu Ser Leu Lys 
545                 550                 555                 560 


Ala Glu Ser Leu Ala Leu Lys Leu Asn Glu Thr Leu Ala Glu Leu Glu 
                565                 570                 575     


Thr Thr Lys Thr Lys Met Ile Met Val Glu Glu Arg Leu Ile Leu Gln 
            580                 585                 590         


Gln Lys Met Val Lys Ala Leu Gln Asp Glu Gln Glu Ser Gln Arg His 
        595                 600                 605             


Gly Phe Glu Glu Glu Ile Met Glu Tyr Lys Glu Gln Ile Lys Gln His 
    610                 615                 620                 


Ala Gln Thr Ile Val Ser Leu Glu Glu Lys Leu Gln Lys Val Thr Gln 
625                 630                 635                 640 


His His Lys Lys Ile Glu Gly Glu Ile Ala Thr Leu Lys Asp Asn Asp 
                645                 650                 655     


Pro Ala Pro Lys Glu Glu Arg Pro Gln Asp Pro Leu Val Ala Pro Met 
            660                 665                 670         


Thr Glu Ser Ser Ala Lys Asp Met Ala Tyr Glu His Leu Ile Asp Asp 
        675                 680                 685             


Leu Leu Ala Ala Gln Lys Glu Ile Leu Ser Gln Gln Glu Val Ile Met 
    690                 695                 700                 


Lys Leu Arg Lys Asp Leu Thr Glu Ala His Ser Arg Met Ser Asp Leu 
705                 710                 715                 720 


Arg Gly Glu Leu Asn Glu Lys Gln Lys Met Glu Leu Glu Gln Asn Val 
                725                 730                 735     


Val Leu Val Gln Gln Gln Ser Lys Glu Leu Ser Val Leu Lys Glu Lys 
            740                 745                 750         


Met Ala Gln Met Ser Ser Leu Val Glu Lys Lys Asp Arg Glu Leu Lys 
        755                 760                 765             


Ala Leu Glu Glu Ala Leu Arg Ala Ser Gln Glu Lys His Arg Leu Gln 
    770                 775                 780                 


Leu Asn Thr Glu Lys Glu Gln Lys Pro Arg Lys Lys Thr Gln Thr Cys 
785                 790                 795                 800 


Asp Thr Ser Val Gln Ile Glu Pro Val His Thr Glu Ala Phe Ser Ser 
                805                 810                 815     


Ser Gln Glu Gln Gln Ser Phe Ser Asp Leu Gly Val Arg Cys Lys Gly 
            820                 825                 830         


Ser Arg His Glu Glu Val Ile Gln Arg Gln Lys Lys Ala Leu Ser Glu 
        835                 840                 845             


Leu Arg Ala Arg Ile Lys Glu Leu Glu Lys Ala Arg Ser Pro Asp His 
    850                 855                 860                 


Lys Asp His Gln Asn Glu Ser Phe Leu Asp Leu Lys Asn Leu Arg Met 
865                 870                 875                 880 


Glu Asn Asn Val Gln Lys Ile Leu Leu Asp Ala Lys Pro Asp Leu Pro 
                885                 890                 895     


Thr Leu Ser Arg Ile Glu Ile Leu Ala Pro Gln Asn Gly Leu Cys Asn 
            900                 905                 910         


Ala Arg Phe Gly Ser Ala Met Glu Lys Ser Gly Lys Met Asp Val Ala 
        915                 920                 925             


Glu Ala Leu Glu Leu Ser Glu Lys Leu Tyr Leu Asp Met Ser Lys Thr 
    930                 935                 940                 


Leu Gly Ser Leu Met Asn Ile Lys Asn Met Ser Gly His Val Ser Met 
945                 950                 955                 960 


Lys Tyr Leu Ser Arg Gln Glu Arg Glu Lys Val Asn Gln Leu Arg Gln 
                965                 970                 975     


Arg Asp Leu Asp Leu Val Phe Asp Lys Ile Thr Gln Leu Lys Asn Gln 
            980                 985                 990         


Leu Gly Arg Lys Glu Glu Leu Leu  Arg Gly Tyr Glu Lys  Asp Val Glu 
        995                 1000                 1005             


Gln Leu  Arg Arg Ser Lys Val  Ser Ile Glu Met Tyr  Gln Ser Gln 
    1010                 1015                 1020             


Val Ala  Lys Leu Glu Asp Asp  Ile Tyr Lys Glu Ala  Glu Glu Lys 
    1025                 1030                 1035             


Ala Leu  Leu Lys Glu Ala Leu  Glu Arg Met Glu His  Gln Leu Cys 
    1040                 1045                 1050             


Gln Glu  Lys Arg Ile Asn Arg  Ala Ile Arg Gln Gln  Lys Met Gly 
    1055                 1060                 1065             


Ala Ser  Ser Pro Cys Leu Ala  Asp Arg Trp 
    1070                 1075             


<210>  15
<211>  1671
<212>  DNA
<213>  Homosapiens

<400>  15
catgattctg aggcctcccc ggccatgtgg aactatcagt gccctacaga aaggctacag     60

caaggtgctg tgccagaccc tgtcagagcg gaactcagaa atcacatccc tgaagaatga    120

gggcgagaac ttaaagagag acaacgctat cacatcaggg atggtgtcat ctttgcaaaa    180

agacatatta gcaaaggatg agcaagttca acaactaaag gaagaggtca gtcacctaaa    240

aagtcagaac aaggacaagg accaccagct ggaagccctt ggctctagac tggagcactt    300

cagaagtcaa gtcatcaagg ccacctatgg acgggcgaag ccgttccggg acaagcccgt    360

caccgaccaa cagttaatag agaaaattac ccaggtcact gaggacaaca tcaattttca    420

gcagaaaaag tggaccctcc agaaagagac ccagctgagc aactccaagc aggaggagac    480

caccgagaac atcgagaagc tgaggacgtc gctggacagc tgccaggctt gcatgaaaat    540

atcctgttgc agccatgacc tgaagaagga ggtcgacctt cttcagcacc tccaggtgag    600

cccacctgtc tcggggctcc agaaggtggt gctggacgtc ctgaggcacg cgctgtcctg    660

gctggaggag gtggagcagc tcctccggga cctcgggatc ctgccctcca gccccaacaa    720

aggttactgg gacttttttt ctcacatggt tgcatgactc taaaatgtcg cgttgaatct    780

cagcatgatg ggacatctgt tgaggaagtc ttcctgggta tctggccaag tctattccct    840

tctccagaac cccctgcttc tctgcttgag gcgtaatttt ccattaaaaa aaaaaacaca    900

cacatacaag tgagacacga taactgaaga aaaatgaaac aaaacagagg caaaaggaaa    960

attaaatcga aattatgcaa agtctaatta cgctgtttaa cctccaaggc attttcccat   1020

ggaaataacc gcgtgattcc aggcaagtga cttaccctgt ctatgcctca gtttccctat   1080

ctgtaaaatg aggctaatag ggagtaccca ccctttaggg ctgttgtgat cattaaaatg   1140

catgaatata tggaaagtac ttggaatagt acctggcaca caataggcat tactgaatgt   1200

ttattgactt ttaatttgac aaaaaaatag tgtcacgtta ccctcgattt tctttggttt   1260

attcctaatg gtacgtcatc catgtcagta gacacagacc tacatcatcg ctgttaccga   1320

cggcagttac tgattccatt gtgtaggatg tgccattgtt ttagacaatc ccctatcatg   1380

ggcacttagg tgatttccag tttttcacac tcataaatca tgctgggatg aacattgttg   1440

cacacatacc tgctcatatt atctttattc tcctagaggt ggagaggtat gaatcacttt   1500

ctttcaacaa atagtgattg catgcatgct taccagaggc cacatgttgt gcagggcaga   1560

gacgtaacgg ggtcaggaac aggtagaatc aggtcatggg tatatggttc actgtaaaat   1620

tcttccaata tgtccataca tttgaaattt tttataataa aatactgggg a            1671


<210>  16
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  16

Met Ile Leu Arg Pro Pro Arg Pro Cys Gly Thr Ile Ser Ala Leu Gln 
1               5                   10                  15      


Lys Gly Tyr Ser Lys Val Leu Cys Gln Thr Leu Ser Glu Arg Asn Ser 
            20                  25                  30          


Glu Ile Thr Ser Leu Lys Asn Glu Gly Glu Asn Leu Lys Arg Asp Asn 
        35                  40                  45              


Ala Ile Thr Ser Gly Met Val Ser Ser Leu Gln Lys Asp Ile Leu Ala 
    50                  55                  60                  


Lys Asp Glu Gln Val Gln Gln Leu Lys Glu Glu Val Ser His Leu Lys 
65                  70                  75                  80  


Ser Gln Asn Lys Asp Lys Asp His Gln Leu Glu Ala Leu Gly Ser Arg 
                85                  90                  95      


Leu Glu His Phe Arg Ser Gln Val Ile Lys Ala Thr Tyr Gly Arg Ala 
            100                 105                 110         


Lys Pro Phe Arg Asp Lys Pro Val Thr Asp Gln Gln Leu Ile Glu Lys 
        115                 120                 125             


Ile Thr Gln Val Thr Glu Asp Asn Ile Asn Phe Gln Gln Lys Lys Trp 
    130                 135                 140                 


Thr Leu Gln Lys Glu Thr Gln Leu Ser Asn Ser Lys Gln Glu Glu Thr 
145                 150                 155                 160 


Thr Glu Asn Ile Glu Lys Leu Arg Thr Ser Leu Asp Ser Cys Gln Ala 
                165                 170                 175     


Cys Met Lys Ile Ser Cys Cys Ser His Asp Leu Lys Lys Glu Val Asp 
            180                 185                 190         


Leu Leu Gln His Leu Gln Val Ser Pro Pro Val Ser Gly Leu Gln Lys 
        195                 200                 205             


Val Val Leu Asp Val Leu Arg His Ala Leu Ser Trp Leu Glu Glu Val 
    210                 215                 220                 


Glu Gln Leu Leu Arg Asp Leu Gly Ile Leu Pro Ser Ser Pro Asn Lys 
225                 230                 235                 240 


Gly Tyr Trp Asp Phe Phe Ser His Met Val Ala 
                245                 250     


<210>  17
<211>  4539
<212>  DNA
<213>  Homosapiens

<400>  17
ccatgtaaga agtgcttttc gcctcccacc atgattctga ggcctccccg gccatgtgga     60

actatcagtg ccctacagaa aggctacagc aaggtgctgt gccagaccct gtcagagcgg    120

aactcagaaa tcacatccct gaagaatgag ggcgagaact taaagagaga caacgctatc    180

acatcaggga tggtgtcatc tttgcaaaaa gacatattag caaaggatga gcaagttcaa    240

caactaaagg aagaggtcag tcacctaaaa agtcagaaca aggacaagga ccaccagctg    300

gaagcccttg gctctagatg ctcggtgcta aaggaagagt taaaacagga agatgctcac    360

agggagctca gggaagccca ggagaaagag ttaaaactct gcaaaaccca aatccaagac    420

atggagaaag aaatgaagaa gcttagggca gagctgagga agagttgtac tgaacaaagc    480

gtgatctcta ggactctgag agaaaaaagc aaggttgaag agaagcttca ggaggattcc    540

agaaggaaat tgcttcagct gcaagaaatg gggaacagag agagcgtcat taaaatcaat    600

ttggagaggg cagtaggtca gctggagcac ttcagaagtc aagtcatcaa ggccacctat    660

ggacgggcga agccgttccg ggacaagccc gtcaccgacc aacagttaat agagaaaatt    720

acccaggtca ctgaggacaa catcaatttt cagcagaaaa agtggaccct ccagaaagag    780

acccagctga gcaactccaa gcaggaggag accaccgaga acatcgagaa gctgaggacg    840

tcgctggaca gctgccaggc ttgcatgaaa atatcctgtt gcagccatga cctgaagaag    900

gaggtcgacc ttcttcagca cctccaggtg agcccacctg tctcggggct ccagaaggtg    960

gtgctggacg tcctgaggca cgcgctgtcc tggctggagg aggtggagca gctcctccgg   1020

gacctcggga tcctgccctc cagccccaac aaagggttct ctttgtatct gatatatctt   1080

ctggaacatt ataaaaaact tatgagccag gcccaggaac ttcagatcaa gttcaacagt   1140

tctcaggaaa ctcagcagtc tttactgcag gaaaagctgc gggagcatct ggcagagaag   1200

gagaagctga acgaggagag gctagagcaa gaggagaagc tcaaagccaa aatcaggcaa   1260

ctgacggaag agaaggcggc tttggaggag tacattactc aagagagaaa cagagcgaaa   1320

gagactttag aggaagaacg gaagagaatg caagaactgg agagcctcct ggcccagcag   1380

aagaaggctt tggcgaaaag cattacccag gagaagaaca gagtgaagga agcattagag   1440

gaagagcaga caagagtcca agagctggag gaacgcttgg cccgccagaa ggagatctca   1500

gagagcaaca ttgcgtacga gaaacgcaaa gcaaaggagg ccatggagaa ggaaaagaaa   1560

aaggtgcaag acctggagaa tcgcttaacc aagcagaaag aggaattaga attaaaagag   1620

caaaaagagg acgttttaaa taataaatta agtgacgcac tggccatggt tgaagagact   1680

cagaaaacaa aggcaactga aagtctaaaa gcagagagcc tcgccttgaa attaaatgaa   1740

acattagccg aactggaaac taccaagaca aaaatgatca tggtggaaga gcggctaatc   1800

ctgcagcaga agatggtaaa ggccctccag gatgagcagg aatcacagag acacgggttt   1860

gaagaagaga tcatggaata taaggagcaa atcaaacagc acgcccagac aattgtgagc   1920

ctcgaagaga aactccagaa agtcactcag caccataaaa aaatagaagg cgagattgca   1980

acattgaagg acaatgaccc agccccaaag gaggaaaggc cgcaagaccc tctggtggct   2040

cccatgacag agagcagtgc caaagacatg gcgtacgaac atctgataga tgacttattg   2100

gctgctcaga aggaaattct gtctcagcag gaagtcatca tgaagttaag gaaagacctt   2160

accgaagccc acagcagaat gtcggatttg agaggggagc taaacgagaa gcagaagatg   2220

gaactggagc agaacgtggt gctggtccag cagcagagca aggagctgag tgtgctcaag   2280

gagaagatgg cccagatgag cagcctggta gaaaagaaag atcgggagct gaaggccctt   2340

gaggaggcac tcagggcttc ccaagagaaa cacagactcc agctgaacac agagaaggaa   2400

cagaagcccc ggaagaagac ccagacgtgt gacacctctg tgcagataga acccgtccac   2460

actgaggcct tctccagcag ccaagagcag caatccttca gcgatctagg ggtcaggtgc   2520

aaagggtccc ggcacgagga ggtcattcag cgtcagaaaa aggccttatc tgaacttcga   2580

gcgcgaatta aagaactcga gaaggcgcgc tcaccagatc ataaagacca ccagaatgaa   2640

tcatttctag atttaaagaa cctcagaatg gaaaacaatg tccagaaaat actactggat   2700

gcaaaaccgg atttgccaac tctctcaaga atagagatcc tagcgcctca gaatggcctt   2760

tgcaacgcaa ggttcggctc agccatggag aagtcaggga agatggatgt ggctgaggct   2820

ttagagctca gtgaaaagct gtacctggat atgagcaaaa ccctcggaag tctcatgaac   2880

atcaagaata tgtcaggcca cgtgtccatg aaatacctct cccgccagga gagggagaag   2940

gtcaaccagc ttcgacaaag ggacctcgac ctggtgtttg ataagatcac ccaactcaag   3000

aaccagctgg ggaggaaaga ggagctgttg agaggatatg aaaaggacgt tgaacagctc   3060

aggcggagca aagtgtccat tgagatgtac cagtcgcagg tggcaaagct ggaggatgat   3120

atctacaaag aggccgaaga gaaggccctg ctgaaggagg ccctggagcg catggagcac   3180

cagctgtgcc aggagaagag gatcaacagg gccatccggc agcagaagat gaggaaactg   3240

cgcctcagag agttaagagg cgcccaagtg cacacagcgg ctggtaagga cagctgggac   3300

ctgaccccag atccctctga ccctggttct cctgctgtct gcagggttgg ccgaaagtgt   3360

agaggagcac gaactgagaa acgcaaaaga atcgacacct tgcaactgtg ccttcaaaga   3420

gaaagacagg caggccctgc cccacctgcc tgcagtttga acggatgacc taagagacaa   3480

gcacgcgtcc agccccgtct gtccattaag agacgagtat ttgtagagat ggtgaagaac   3540

aggatgcaga actcaaattc ccaggttgga accagaaaag cctccctaaa gatggaccaa   3600

gaaagagaga tgctgaggaa agagacctcc agcaagtcca gccagagcct tttgcattct   3660

aagcccagtg gaaagtacta gagaaacctc gtcccaccag gcctcatgtg atcctctgtg   3720

agttcatgtg actcttctgt gtcatctgtg tcaaaatact gagttgcttt tgtaagtctt   3780

taaagattgt taccctagtg tttcatttcc tagaccagta ttttgaacaa tattatattt   3840

tggagactgt ggggagaagg gttcttcttt aaaaatacct atgaatgtac acgaactcag   3900

gtatatgaag aatagaagtg tgtaacccag atgtccaggc ctggtagata taattatgtg   3960

gtccacgttg ggtcatgatg ttcccaaata tcaaacctcc taagacttcc aacagactca   4020

cacttgagaa aacctaagac ttgtactgga gcctcagggc agaattgtaa ccttggagct   4080

ctcagggcct tgggatagtg aattcaagtc tccgttatgg cctggcagga tggctcatgc   4140

ctgtaatctc agcactttgg gaggccgagg caggcggatt ataagatcag gagtttgaga   4200

ccagcctggc aaacatagtg aatacctgtc tctactaaaa atacaaaaat tagccaggtg   4260

tggtggcaca tgcctgtagt cccagctaca caggaggctg aggtgggaga atcacttgaa   4320

cctaggaggc agaggttgca gtgagccaag accacgccat tgcacgccag cctaacagag   4380

tgagactctg tctttaaaaa aaaaaaaaaa tggctgggcc tgtaatccca gctactcggg   4440

aggctgagac aggagaatca cttcaacccg ggaggtgatg attgcaggga gccaagatca   4500

cacaactgca ctctagcctg agtgacagag caagactcc                          4539


<210>  18
<211>  1145
<212>  PRT
<213>  Homosapiens

<400>  18

Met Ile Leu Arg Pro Pro Arg Pro Cys Gly Thr Ile Ser Ala Leu Gln 
1               5                   10                  15      


Lys Gly Tyr Ser Lys Val Leu Cys Gln Thr Leu Ser Glu Arg Asn Ser 
            20                  25                  30          


Glu Ile Thr Ser Leu Lys Asn Glu Gly Glu Asn Leu Lys Arg Asp Asn 
        35                  40                  45              


Ala Ile Thr Ser Gly Met Val Ser Ser Leu Gln Lys Asp Ile Leu Ala 
    50                  55                  60                  


Lys Asp Glu Gln Val Gln Gln Leu Lys Glu Glu Val Ser His Leu Lys 
65                  70                  75                  80  


Ser Gln Asn Lys Asp Lys Asp His Gln Leu Glu Ala Leu Gly Ser Arg 
                85                  90                  95      


Cys Ser Val Leu Lys Glu Glu Leu Lys Gln Glu Asp Ala His Arg Glu 
            100                 105                 110         


Leu Arg Glu Ala Gln Glu Lys Glu Leu Lys Leu Cys Lys Thr Gln Ile 
        115                 120                 125             


Gln Asp Met Glu Lys Glu Met Lys Lys Leu Arg Ala Glu Leu Arg Lys 
    130                 135                 140                 


Ser Cys Thr Glu Gln Ser Val Ile Ser Arg Thr Leu Arg Glu Lys Ser 
145                 150                 155                 160 


Lys Val Glu Glu Lys Leu Gln Glu Asp Ser Arg Arg Lys Leu Leu Gln 
                165                 170                 175     


Leu Gln Glu Met Gly Asn Arg Glu Ser Val Ile Lys Ile Asn Leu Glu 
            180                 185                 190         


Arg Ala Val Gly Gln Leu Glu His Phe Arg Ser Gln Val Ile Lys Ala 
        195                 200                 205             


Thr Tyr Gly Arg Ala Lys Pro Phe Arg Asp Lys Pro Val Thr Asp Gln 
    210                 215                 220                 


Gln Leu Ile Glu Lys Ile Thr Gln Val Thr Glu Asp Asn Ile Asn Phe 
225                 230                 235                 240 


Gln Gln Lys Lys Trp Thr Leu Gln Lys Glu Thr Gln Leu Ser Asn Ser 
                245                 250                 255     


Lys Gln Glu Glu Thr Thr Glu Asn Ile Glu Lys Leu Arg Thr Ser Leu 
            260                 265                 270         


Asp Ser Cys Gln Ala Cys Met Lys Ile Ser Cys Cys Ser His Asp Leu 
        275                 280                 285             


Lys Lys Glu Val Asp Leu Leu Gln His Leu Gln Val Ser Pro Pro Val 
    290                 295                 300                 


Ser Gly Leu Gln Lys Val Val Leu Asp Val Leu Arg His Ala Leu Ser 
305                 310                 315                 320 


Trp Leu Glu Glu Val Glu Gln Leu Leu Arg Asp Leu Gly Ile Leu Pro 
                325                 330                 335     


Ser Ser Pro Asn Lys Gly Phe Ser Leu Tyr Leu Ile Tyr Leu Leu Glu 
            340                 345                 350         


His Tyr Lys Lys Leu Met Ser Gln Ala Gln Glu Leu Gln Ile Lys Phe 
        355                 360                 365             


Asn Ser Ser Gln Glu Thr Gln Gln Ser Leu Leu Gln Glu Lys Leu Arg 
    370                 375                 380                 


Glu His Leu Ala Glu Lys Glu Lys Leu Asn Glu Glu Arg Leu Glu Gln 
385                 390                 395                 400 


Glu Glu Lys Leu Lys Ala Lys Ile Arg Gln Leu Thr Glu Glu Lys Ala 
                405                 410                 415     


Ala Leu Glu Glu Tyr Ile Thr Gln Glu Arg Asn Arg Ala Lys Glu Thr 
            420                 425                 430         


Leu Glu Glu Glu Arg Lys Arg Met Gln Glu Leu Glu Ser Leu Leu Ala 
        435                 440                 445             


Gln Gln Lys Lys Ala Leu Ala Lys Ser Ile Thr Gln Glu Lys Asn Arg 
    450                 455                 460                 


Val Lys Glu Ala Leu Glu Glu Glu Gln Thr Arg Val Gln Glu Leu Glu 
465                 470                 475                 480 


Glu Arg Leu Ala Arg Gln Lys Glu Ile Ser Glu Ser Asn Ile Ala Tyr 
                485                 490                 495     


Glu Lys Arg Lys Ala Lys Glu Ala Met Glu Lys Glu Lys Lys Lys Val 
            500                 505                 510         


Gln Asp Leu Glu Asn Arg Leu Thr Lys Gln Lys Glu Glu Leu Glu Leu 
        515                 520                 525             


Lys Glu Gln Lys Glu Asp Val Leu Asn Asn Lys Leu Ser Asp Ala Leu 
    530                 535                 540                 


Ala Met Val Glu Glu Thr Gln Lys Thr Lys Ala Thr Glu Ser Leu Lys 
545                 550                 555                 560 


Ala Glu Ser Leu Ala Leu Lys Leu Asn Glu Thr Leu Ala Glu Leu Glu 
                565                 570                 575     


Thr Thr Lys Thr Lys Met Ile Met Val Glu Glu Arg Leu Ile Leu Gln 
            580                 585                 590         


Gln Lys Met Val Lys Ala Leu Gln Asp Glu Gln Glu Ser Gln Arg His 
        595                 600                 605             


Gly Phe Glu Glu Glu Ile Met Glu Tyr Lys Glu Gln Ile Lys Gln His 
    610                 615                 620                 


Ala Gln Thr Ile Val Ser Leu Glu Glu Lys Leu Gln Lys Val Thr Gln 
625                 630                 635                 640 


His His Lys Lys Ile Glu Gly Glu Ile Ala Thr Leu Lys Asp Asn Asp 
                645                 650                 655     


Pro Ala Pro Lys Glu Glu Arg Pro Gln Asp Pro Leu Val Ala Pro Met 
            660                 665                 670         


Thr Glu Ser Ser Ala Lys Asp Met Ala Tyr Glu His Leu Ile Asp Asp 
        675                 680                 685             


Leu Leu Ala Ala Gln Lys Glu Ile Leu Ser Gln Gln Glu Val Ile Met 
    690                 695                 700                 


Lys Leu Arg Lys Asp Leu Thr Glu Ala His Ser Arg Met Ser Asp Leu 
705                 710                 715                 720 


Arg Gly Glu Leu Asn Glu Lys Gln Lys Met Glu Leu Glu Gln Asn Val 
                725                 730                 735     


Val Leu Val Gln Gln Gln Ser Lys Glu Leu Ser Val Leu Lys Glu Lys 
            740                 745                 750         


Met Ala Gln Met Ser Ser Leu Val Glu Lys Lys Asp Arg Glu Leu Lys 
        755                 760                 765             


Ala Leu Glu Glu Ala Leu Arg Ala Ser Gln Glu Lys His Arg Leu Gln 
    770                 775                 780                 


Leu Asn Thr Glu Lys Glu Gln Lys Pro Arg Lys Lys Thr Gln Thr Cys 
785                 790                 795                 800 


Asp Thr Ser Val Gln Ile Glu Pro Val His Thr Glu Ala Phe Ser Ser 
                805                 810                 815     


Ser Gln Glu Gln Gln Ser Phe Ser Asp Leu Gly Val Arg Cys Lys Gly 
            820                 825                 830         


Ser Arg His Glu Glu Val Ile Gln Arg Gln Lys Lys Ala Leu Ser Glu 
        835                 840                 845             


Leu Arg Ala Arg Ile Lys Glu Leu Glu Lys Ala Arg Ser Pro Asp His 
    850                 855                 860                 


Lys Asp His Gln Asn Glu Ser Phe Leu Asp Leu Lys Asn Leu Arg Met 
865                 870                 875                 880 


Glu Asn Asn Val Gln Lys Ile Leu Leu Asp Ala Lys Pro Asp Leu Pro 
                885                 890                 895     


Thr Leu Ser Arg Ile Glu Ile Leu Ala Pro Gln Asn Gly Leu Cys Asn 
            900                 905                 910         


Ala Arg Phe Gly Ser Ala Met Glu Lys Ser Gly Lys Met Asp Val Ala 
        915                 920                 925             


Glu Ala Leu Glu Leu Ser Glu Lys Leu Tyr Leu Asp Met Ser Lys Thr 
    930                 935                 940                 


Leu Gly Ser Leu Met Asn Ile Lys Asn Met Ser Gly His Val Ser Met 
945                 950                 955                 960 


Lys Tyr Leu Ser Arg Gln Glu Arg Glu Lys Val Asn Gln Leu Arg Gln 
                965                 970                 975     


Arg Asp Leu Asp Leu Val Phe Asp Lys Ile Thr Gln Leu Lys Asn Gln 
            980                 985                 990         


Leu Gly Arg Lys Glu Glu Leu Leu  Arg Gly Tyr Glu Lys  Asp Val Glu 
        995                 1000                 1005             


Gln Leu  Arg Arg Ser Lys Val  Ser Ile Glu Met Tyr  Gln Ser Gln 
    1010                 1015                 1020             


Val Ala  Lys Leu Glu Asp Asp  Ile Tyr Lys Glu Ala  Glu Glu Lys 
    1025                 1030                 1035             


Ala Leu  Leu Lys Glu Ala Leu  Glu Arg Met Glu His  Gln Leu Cys 
    1040                 1045                 1050             


Gln Glu  Lys Arg Ile Asn Arg  Ala Ile Arg Gln Gln  Lys Met Arg 
    1055                 1060                 1065             


Lys Leu  Arg Leu Arg Glu Leu  Arg Gly Ala Gln Val  His Thr Ala 
    1070                 1075                 1080             


Ala Gly  Lys Asp Ser Trp Asp  Leu Thr Pro Asp Pro  Ser Asp Pro 
    1085                 1090                 1095             


Gly Ser  Pro Ala Val Cys Arg  Val Gly Arg Lys Cys  Arg Gly Ala 
    1100                 1105                 1110             


Arg Thr  Glu Lys Arg Lys Arg  Ile Asp Thr Leu Gln  Leu Cys Leu 
    1115                 1120                 1125             


Gln Arg  Glu Arg Gln Ala Gly  Pro Ala Pro Pro Ala  Cys Ser Leu 
    1130                 1135                 1140             


Asn Gly  
    1145 


<210>  19
<211>  356
<212>  DNA
<213>  Homosapiens

<400>  19
ccatgcaggt ggtctcctgg atgaggaaac tgcgcctcag agagttaaga ggcgcccaag     60

tgcacacagc ggctgagacg agtatttgta gagatggtga agaacaggat gcagaactca    120

aattcccagg ttggaaccag aaaagcctcc ctaaagatgg accaagaaag agagatgctg    180

aggaaagaga cctccagcaa gtccagccag agccttttgc attctaagcc cagtggaaag    240

tactagagaa acctcgtccc accaggcctc atgtgatcct ctgtgagttc atgtgactct    300

tctgtgtcat ctgtgtcaaa atactgagtt gcttttgtaa gtctttaaag attgtt        356


<210>  20
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  20

Met Gln Val Val Ser Trp Met Arg Lys Leu Arg Leu Arg Glu Leu Arg 
1               5                   10                  15      


Gly Ala Gln Val His Thr Ala Ala Glu Thr Ser Ile Cys Arg Asp Gly 
            20                  25                  30          


Glu Glu Gln Asp Ala Glu Leu Lys Phe Pro Gly Trp Asn Gln Lys Ser 
        35                  40                  45              


Leu Pro Lys Asp Gly Pro Arg Lys Arg Asp Ala Glu Glu Arg Asp Leu 
    50                  55                  60                  


Gln Gln Val Gln Pro Glu Pro Phe Ala Phe 
65                  70                  


<210>  21
<211>  4203
<212>  DNA
<213>  Homosapiens

<400>  21
ccatgtaaga agtgcttttc gcctcccacc atgattctga ggcctccccg gccatgtgga     60

actatcagtg ccctacagaa aggctacagc aaggtgctgt gccagaccct gtcagagcgg    120

aactcagaaa tcacatccct gaagaatgag ggcgagaact taaagagaga caacgctatc    180

acatcaggga tggtgtcatc tttgcaaaaa gacatattag caaaggatga gcaagttcaa    240

caactaaagg aagaggtcag tcacctaaaa agtcagaaca aggacaagga ccaccagctg    300

gaagcccttg gctctagatg ctcggtgcta aaggaagagt taaaacagga agatgctcac    360

agggagctca gggaagccca ggagaaagag ttaaaactct gcaaaaccca aatccaagac    420

atggagaaag aaatgaagaa gcttagggca gagctgagga agagttgtac tgaacaaagc    480

gtgatctcta ggactctgag agaaaaaagc aaggttgaag agaagcttca ggaggattcc    540

agaaggaaat tgcttcagct gcaagaaatg gggaacagag agagcgtcat taaaatcaat    600

ttggagaggg cagtaggtca gctggagcac ttcagaagtc aagtcatcaa ggccacctat    660

ggacgggcga agccgttccg ggacaagccc gtcaccgacc aacagttaat agagaaaatt    720

acccaggtca ctgaggacaa catcaatttt cagcagaaaa agtggaccct ccagaaagag    780

acccagctga gcaactccaa gcaggaggag accaccgaga acatcgagaa gctgaggacg    840

tcgctggaca gctgccaggc ttgcatgaaa atatcctgtt gcagccatga cctgaagaag    900

gaggtcgacc ttcttcagca cctccaggtg agcccacctg tctcggggct ccagaaggtg    960

gtgctggacg tcctgaggca cgcgctgtcc tggctggagg aggtggagca gctcctccgg   1020

gacctcggga tcctgccctc cagccccaac aaagggttct ctttgtatct gatatatctt   1080

ctggaacatt ataaaaaact tatgagccag gcccaggaac ttcagatcaa gttcaacagt   1140

tctcaggaaa ctcagcagtc tttactgcag gaaaagctgc gggagcatct ggcagagaag   1200

gagaagctga acgaggagag gctagagcaa gaggagaagc tcaaagccaa aatcaggcaa   1260

ctgacggaag agaaggcggc tttggaggag tacattactc aagagagaaa cagagcgaaa   1320

gagactttag aggaagaacg gaagagaatg caagaactgg agagcctcct ggcccagcag   1380

aagaaggctt tggcgaaaag cattacccag gagaagaaca gagtgaagga agcattagag   1440

gaagagcaga caagagtcca agagctggag gaacgcttgg cccgccagaa ggagatctca   1500

gagagcaaca ttgcgtacga gaaacgcaaa gcaaaggagg ccatggagaa ggaaaagaaa   1560

aaggtgcaag acctggagaa tcgcttaacc aagcagaaag aggaattaga attaaaagag   1620

caaaaagagg acgttttaaa taataaatta agtgacgcac tggccatggt tgaagagact   1680

cagaaaacaa aggcaactga aagtctaaaa gcagagagcc tcgccttgaa attaaatgaa   1740

acattagccg aactggaaac taccaagaca aaaatgatca tggtggaaga gcggctaatc   1800

ctgcagcaga agatggtaaa ggccctccag gatgagcagg aatcacagag acacgggttt   1860

gaagaagaga tcatggaata taaggagcaa atcaaacagc acgcccagac aattgtgagc   1920

ctcgaagaga aactccagaa agtcactcag caccataaaa aaatagaagg cgagattgca   1980

acattgaagg acaatgaccc agccccaaag gaggaaaggc cgcaagaccc tctggtggct   2040

cccatgacag agagcagtgc caaagacatg gcgtacgaac atctgataga tgacttattg   2100

gctgctcaga aggaaattct gtctcagcag gaagtcatca tgaagttaag gaaagacctt   2160

accgaagccc acagcagaat gtcggatttg agaggggagc taaacgagaa gcagaagatg   2220

gaactggagc agaacgtggt gctggtccag cagcagagca aggagctgag tgtgctcaag   2280

gagaagatgg cccagatgag cagcctggta gaaaagaaag atcgggagct gaaggccctt   2340

gaggaggcac tcagggcttc ccaagagaaa cacagactcc agctgaacac agagaaggaa   2400

cagaagcccc ggaagaagac ccagacgtgt gacacctctg tgcagataga acccgtccac   2460

actgaggcct tctccagcag ccaagagcag caatccttca gcgatctagg ggtcaggtgc   2520

aaagggtccc ggcacgagga ggtcattcag cgtcagaaaa aggccttatc tgaacttcga   2580

gcgcgaatta aagaactcga gaaggcgcgc tcaccagatc ataaagacca ccagaatgaa   2640

tcatttctag atttaaagaa cctcagaatg gaaaacaatg tccagaaaat actactggat   2700

gcaaaaccgg atttgccaac tctctcaaga atagagatcc tagcgcctca gaatggcctt   2760

tgcaacgcaa ggttcggctc agccatggag aagtcaggga agatggatgt ggctgaggct   2820

ttagagctca gtgaaaagct gtacctggat atgagcaaaa ccctcggaag tctcatgaac   2880

atcaagaata tgtcaggcca cgtgtccatg aaatacctct cccgccagga gagggagaag   2940

gtcaaccagc ttcgacaaag ggacctcgac ctggtgtttg ataagatcac ccaactcaag   3000

aaccagctgg ggaggaaaga ggagctgttg agaggatatg aaaaggacgt tgaacagctc   3060

aggcggagca aagtgtccat tgagatgtac cagtcgcagg tggcaaagct ggaggatgat   3120

atctacaaag aggccgaaga gaaggccctg ctgaaggagg ccctggagcg catggagcac   3180

cagctgtgcc aggagaagag gatcaacagg gccatccggc agcagaaggt tggaaccaga   3240

aaagcctccc taaagatgga ccaagaaaga gagatgctga ggaaagagac ctccagcaag   3300

tccagccaga gccttttgca ttctaagccc agtggaaagt actagagaaa cctcgtccca   3360

ccaggcctca tgtgatcctc tgtgagttca tgtgactctt ctgtgtcatc tgtgtcaaaa   3420

tactgagttg cttttgtaag tctttaaaga ttgttaccct agtgtttcat ttcctagacc   3480

agtattttga acaatattat attttggaga ctgtggggag aagggttctt ctttaaaaat   3540

acctatgaat gtacacgaac tcaggtatat gaagaataga agtgtgtaac ccagatgtcc   3600

aggcctggta gatataatta tgtggtccac gttgggtcat gatgttccca aatatcaaac   3660

ctcctaagac ttccaacaga ctcacacttg agaaaaccta agacttgtac tggagcctca   3720

gggcagaatt gtaaccttgg agctctcagg gccttgggat agtgaattca agtctccgtt   3780

atggcctggc aggatggctc atgcctgtaa tctcagcact ttgggaggcc gaggcaggcg   3840

gattataaga tcaggagttt gagaccagcc tggcaaacat agtgaatacc tgtctctact   3900

aaaaatacaa aaattagcca ggtgtggtgg cacatgcctg tagtcccagc tacacaggag   3960

gctgaggtgg gagaatcact tgaacctagg aggcagaggt tgcagtgagc caagaccacg   4020

ccattgcacg ccagcctaac agagtgagac tctgtcttta aaaaaaaaaa aaaatggctg   4080

ggcctgtaat cccagctact cgggaggctg agacaggaga atcacttcaa cccgggaggt   4140

gatgattgca gggagccaag atcacacaac tgcactctag cctgagtgac agagcaagac   4200

tcc                                                                 4203


<210>  22
<211>  1104
<212>  PRT
<213>  Homosapiens

<400>  22

Met Ile Leu Arg Pro Pro Arg Pro Cys Gly Thr Ile Ser Ala Leu Gln 
1               5                   10                  15      


Lys Gly Tyr Ser Lys Val Leu Cys Gln Thr Leu Ser Glu Arg Asn Ser 
            20                  25                  30          


Glu Ile Thr Ser Leu Lys Asn Glu Gly Glu Asn Leu Lys Arg Asp Asn 
        35                  40                  45              


Ala Ile Thr Ser Gly Met Val Ser Ser Leu Gln Lys Asp Ile Leu Ala 
    50                  55                  60                  


Lys Asp Glu Gln Val Gln Gln Leu Lys Glu Glu Val Ser His Leu Lys 
65                  70                  75                  80  


Ser Gln Asn Lys Asp Lys Asp His Gln Leu Glu Ala Leu Gly Ser Arg 
                85                  90                  95      


Cys Ser Val Leu Lys Glu Glu Leu Lys Gln Glu Asp Ala His Arg Glu 
            100                 105                 110         


Leu Arg Glu Ala Gln Glu Lys Glu Leu Lys Leu Cys Lys Thr Gln Ile 
        115                 120                 125             


Gln Asp Met Glu Lys Glu Met Lys Lys Leu Arg Ala Glu Leu Arg Lys 
    130                 135                 140                 


Ser Cys Thr Glu Gln Ser Val Ile Ser Arg Thr Leu Arg Glu Lys Ser 
145                 150                 155                 160 


Lys Val Glu Glu Lys Leu Gln Glu Asp Ser Arg Arg Lys Leu Leu Gln 
                165                 170                 175     


Leu Gln Glu Met Gly Asn Arg Glu Ser Val Ile Lys Ile Asn Leu Glu 
            180                 185                 190         


Arg Ala Val Gly Gln Leu Glu His Phe Arg Ser Gln Val Ile Lys Ala 
        195                 200                 205             


Thr Tyr Gly Arg Ala Lys Pro Phe Arg Asp Lys Pro Val Thr Asp Gln 
    210                 215                 220                 


Gln Leu Ile Glu Lys Ile Thr Gln Val Thr Glu Asp Asn Ile Asn Phe 
225                 230                 235                 240 


Gln Gln Lys Lys Trp Thr Leu Gln Lys Glu Thr Gln Leu Ser Asn Ser 
                245                 250                 255     


Lys Gln Glu Glu Thr Thr Glu Asn Ile Glu Lys Leu Arg Thr Ser Leu 
            260                 265                 270         


Asp Ser Cys Gln Ala Cys Met Lys Ile Ser Cys Cys Ser His Asp Leu 
        275                 280                 285             


Lys Lys Glu Val Asp Leu Leu Gln His Leu Gln Val Ser Pro Pro Val 
    290                 295                 300                 


Ser Gly Leu Gln Lys Val Val Leu Asp Val Leu Arg His Ala Leu Ser 
305                 310                 315                 320 


Trp Leu Glu Glu Val Glu Gln Leu Leu Arg Asp Leu Gly Ile Leu Pro 
                325                 330                 335     


Ser Ser Pro Asn Lys Gly Phe Ser Leu Tyr Leu Ile Tyr Leu Leu Glu 
            340                 345                 350         


His Tyr Lys Lys Leu Met Ser Gln Ala Gln Glu Leu Gln Ile Lys Phe 
        355                 360                 365             


Asn Ser Ser Gln Glu Thr Gln Gln Ser Leu Leu Gln Glu Lys Leu Arg 
    370                 375                 380                 


Glu His Leu Ala Glu Lys Glu Lys Leu Asn Glu Glu Arg Leu Glu Gln 
385                 390                 395                 400 


Glu Glu Lys Leu Lys Ala Lys Ile Arg Gln Leu Thr Glu Glu Lys Ala 
                405                 410                 415     


Ala Leu Glu Glu Tyr Ile Thr Gln Glu Arg Asn Arg Ala Lys Glu Thr 
            420                 425                 430         


Leu Glu Glu Glu Arg Lys Arg Met Gln Glu Leu Glu Ser Leu Leu Ala 
        435                 440                 445             


Gln Gln Lys Lys Ala Leu Ala Lys Ser Ile Thr Gln Glu Lys Asn Arg 
    450                 455                 460                 


Val Lys Glu Ala Leu Glu Glu Glu Gln Thr Arg Val Gln Glu Leu Glu 
465                 470                 475                 480 


Glu Arg Leu Ala Arg Gln Lys Glu Ile Ser Glu Ser Asn Ile Ala Tyr 
                485                 490                 495     


Glu Lys Arg Lys Ala Lys Glu Ala Met Glu Lys Glu Lys Lys Lys Val 
            500                 505                 510         


Gln Asp Leu Glu Asn Arg Leu Thr Lys Gln Lys Glu Glu Leu Glu Leu 
        515                 520                 525             


Lys Glu Gln Lys Glu Asp Val Leu Asn Asn Lys Leu Ser Asp Ala Leu 
    530                 535                 540                 


Ala Met Val Glu Glu Thr Gln Lys Thr Lys Ala Thr Glu Ser Leu Lys 
545                 550                 555                 560 


Ala Glu Ser Leu Ala Leu Lys Leu Asn Glu Thr Leu Ala Glu Leu Glu 
                565                 570                 575     


Thr Thr Lys Thr Lys Met Ile Met Val Glu Glu Arg Leu Ile Leu Gln 
            580                 585                 590         


Gln Lys Met Val Lys Ala Leu Gln Asp Glu Gln Glu Ser Gln Arg His 
        595                 600                 605             


Gly Phe Glu Glu Glu Ile Met Glu Tyr Lys Glu Gln Ile Lys Gln His 
    610                 615                 620                 


Ala Gln Thr Ile Val Ser Leu Glu Glu Lys Leu Gln Lys Val Thr Gln 
625                 630                 635                 640 


His His Lys Lys Ile Glu Gly Glu Ile Ala Thr Leu Lys Asp Asn Asp 
                645                 650                 655     


Pro Ala Pro Lys Glu Glu Arg Pro Gln Asp Pro Leu Val Ala Pro Met 
            660                 665                 670         


Thr Glu Ser Ser Ala Lys Asp Met Ala Tyr Glu His Leu Ile Asp Asp 
        675                 680                 685             


Leu Leu Ala Ala Gln Lys Glu Ile Leu Ser Gln Gln Glu Val Ile Met 
    690                 695                 700                 


Lys Leu Arg Lys Asp Leu Thr Glu Ala His Ser Arg Met Ser Asp Leu 
705                 710                 715                 720 


Arg Gly Glu Leu Asn Glu Lys Gln Lys Met Glu Leu Glu Gln Asn Val 
                725                 730                 735     


Val Leu Val Gln Gln Gln Ser Lys Glu Leu Ser Val Leu Lys Glu Lys 
            740                 745                 750         


Met Ala Gln Met Ser Ser Leu Val Glu Lys Lys Asp Arg Glu Leu Lys 
        755                 760                 765             


Ala Leu Glu Glu Ala Leu Arg Ala Ser Gln Glu Lys His Arg Leu Gln 
    770                 775                 780                 


Leu Asn Thr Glu Lys Glu Gln Lys Pro Arg Lys Lys Thr Gln Thr Cys 
785                 790                 795                 800 


Asp Thr Ser Val Gln Ile Glu Pro Val His Thr Glu Ala Phe Ser Ser 
                805                 810                 815     


Ser Gln Glu Gln Gln Ser Phe Ser Asp Leu Gly Val Arg Cys Lys Gly 
            820                 825                 830         


Ser Arg His Glu Glu Val Ile Gln Arg Gln Lys Lys Ala Leu Ser Glu 
        835                 840                 845             


Leu Arg Ala Arg Ile Lys Glu Leu Glu Lys Ala Arg Ser Pro Asp His 
    850                 855                 860                 


Lys Asp His Gln Asn Glu Ser Phe Leu Asp Leu Lys Asn Leu Arg Met 
865                 870                 875                 880 


Glu Asn Asn Val Gln Lys Ile Leu Leu Asp Ala Lys Pro Asp Leu Pro 
                885                 890                 895     


Thr Leu Ser Arg Ile Glu Ile Leu Ala Pro Gln Asn Gly Leu Cys Asn 
            900                 905                 910         


Ala Arg Phe Gly Ser Ala Met Glu Lys Ser Gly Lys Met Asp Val Ala 
        915                 920                 925             


Glu Ala Leu Glu Leu Ser Glu Lys Leu Tyr Leu Asp Met Ser Lys Thr 
    930                 935                 940                 


Leu Gly Ser Leu Met Asn Ile Lys Asn Met Ser Gly His Val Ser Met 
945                 950                 955                 960 


Lys Tyr Leu Ser Arg Gln Glu Arg Glu Lys Val Asn Gln Leu Arg Gln 
                965                 970                 975     


Arg Asp Leu Asp Leu Val Phe Asp Lys Ile Thr Gln Leu Lys Asn Gln 
            980                 985                 990         


Leu Gly Arg Lys Glu Glu Leu Leu  Arg Gly Tyr Glu Lys  Asp Val Glu 
        995                 1000                 1005             


Gln Leu  Arg Arg Ser Lys Val  Ser Ile Glu Met Tyr  Gln Ser Gln 
    1010                 1015                 1020             


Val Ala  Lys Leu Glu Asp Asp  Ile Tyr Lys Glu Ala  Glu Glu Lys 
    1025                 1030                 1035             


Ala Leu  Leu Lys Glu Ala Leu  Glu Arg Met Glu His  Gln Leu Cys 
    1040                 1045                 1050             


Gln Glu  Lys Arg Ile Asn Arg  Ala Ile Arg Gln Gln  Lys Val Gly 
    1055                 1060                 1065             


Thr Arg  Lys Ala Ser Leu Lys  Met Asp Gln Glu Arg  Glu Met Leu 
    1070                 1075                 1080             


Arg Lys  Glu Thr Ser Ser Lys  Ser Ser Gln Ser Leu  Leu His Ser 
    1085                 1090                 1095             


Lys Pro  Ser Gly Lys Tyr 
    1100                 


<210>  23
<211>  2387
<212>  DNA
<213>  Homosapiens

<400>  23
gccaaggcga gtgccgcgcg ggccaccatg gccacggacg agctggccac caagctgagc     60

cggcggctgc agatggaggg cgagggcggc ggcgagaccc cggagcagcc cgggctgaac    120

ggggcagcgg cggcggcggc gggggcaccc gacgaggcgg ccgaggcgct gggcagcgcg    180

gactgcgagc tgagcgccaa gctgctgcgg cgcgcagacc tcaaccaggg catcggcgag    240

ccccagtcgc ccagccgccg cgtcttcaac ccctacaccg agttcaagga gttctccagg    300

aagcagatca aggacatgga gaagatgttc aagcagtatg atgccgggcg ggacggcttc    360

atcgacctga tggagctaaa actcatgatg gagaaacttg gggcccctca gacccacctg    420

ggcctgaaaa acatgatcaa ggaggtggat gaggactttg acagcaagct gagcttccgg    480

gagttcctcc tgatcttccg caaggcggcg gccggggagc ttcaggagga cagcgggctg    540

tgcgtgctgg cccgcctctc tgagatcgac gtctccagtg agggtgtcaa gggggccaag    600

agcttctttg aggccaaggt ccaggccatc aacgtgtcca gccgcttcga ggaggagatc    660

aaggcagagc aggaggaaag gaagaagcag gcggaggaga tgaagcagcg gaaagcggcc    720

ttcaaggagc tgcagtccac ctttaagtag cgggggctgc agccgaccgc cctgctctgg    780

ccccagtgtg gtgggcgagg gtggcgcatg ggaggccgag cctgaatcct tgcctgtgtc    840

tgacgggacc actactaaaa acctaaaaat atctgtgaat ggagcaagtt caggggtctt    900

atggaggtgg cccggcccct ccccgctccc ttccactctg cacgaggccg ccacaccggc    960

gctggctccc tgcccggccc ggccctccct ggcaatccct gggctctctt gcacccctaa   1020

ctgccccctg cctgctccgg cactgcccca ggcccagctc ctggccctag gtccctccca   1080

gccccatgtg cctgccgcct gccctccaca catccctgtc cccccaaccc gggaacccct   1140

gccctcctcc agcaggccgc accgcccctg gggccccctg ccagcccctt cccaggctgg   1200

gagacggcag aagagataga atcagggctg cccccacaga gtgggaccca aggggctaat   1260

tggaggcacg aggggacccc tccccagggc cttttcctcc tctgcgtctt ccatctactg   1320

aaatgggaga gggggtgggg agcttctgtt ctggtgaagg gacccgggca ggcccccagc   1380

accccatgct gacttggaga accccagatc tctggggccc agccaggcag ggtgtggggg   1440

cagctgtgcc aatctacctc acaggcccac cccctgccgg gcatgccgtg ggatcatggg   1500

cagggaaggc tctgggggtc ggagacaccg ctgcttagca cccccagcca gaacaccctg   1560

agggtctcgg ggctctggag agagtggggc gggaggaaga attggcacct tcctagggaa   1620

ggagacgagc gcttcgcctt gattctccga gaagcctccg agaagtgctt taagtgtgtt   1680

tgcatgcgcc aggcggtggg cagcgggggc ctgtccagcc ctctcccgcc atccttcccc   1740

aagtgacgtc cactgccttg tcaccagcga cctgcctgtc atgcccaccc cctgaggaag   1800

catggggacc ctaacaccct ggtgccctgc accagacagg ccgtggtcag gcccaggcca   1860

ccggccgggt tctgccacag cttcccacgt gcttgctgac atgcgtgtgc ctgtgtgtgg   1920

tgtctgttgc tgtgtcgtga aactgtgacc atcactcagt ccaaacaagt gagtggccct   1980

cgaggccaca gttatgcaac tttcagtgtg tgtcataacg acgtcactgc tttttaaact   2040

cgataactct ttattttagt aaaatgccca ggagtcctgg aagctacgcg gacttgcaga   2100

ggttttattt tttggcctta gaatctgcag aaattaggag gcaccgagcc cagcgcagca   2160

gcctcggacc cggattgcgt ttgccttagc ggatatgttt atacagatga atataaaatg   2220

tttttttctt tgggcttttt gcttcttttt tccccccctt ctcaccttcc cttctccccg   2280

accccacccc ccaaaaaagc tacttcttca ttccgtggta cgattatttt ttttaactaa   2340

aggaagataa aattctatat tcttaaaaaa aaaaaaaaaa aaaaaaa                 2387


<210>  24
<211>  240
<212>  PRT
<213>  Homosapiens

<400>  24

Met Ala Thr Asp Glu Leu Ala Thr Lys Leu Ser Arg Arg Leu Gln Met 
1               5                   10                  15      


Glu Gly Glu Gly Gly Gly Glu Thr Pro Glu Gln Pro Gly Leu Asn Gly 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Gly Ala Pro Asp Glu Ala Ala Glu Ala Leu 
        35                  40                  45              


Gly Ser Ala Asp Cys Glu Leu Ser Ala Lys Leu Leu Arg Arg Ala Asp 
    50                  55                  60                  


Leu Asn Gln Gly Ile Gly Glu Pro Gln Ser Pro Ser Arg Arg Val Phe 
65                  70                  75                  80  


Asn Pro Tyr Thr Glu Phe Lys Glu Phe Ser Arg Lys Gln Ile Lys Asp 
                85                  90                  95      


Met Glu Lys Met Phe Lys Gln Tyr Asp Ala Gly Arg Asp Gly Phe Ile 
            100                 105                 110         


Asp Leu Met Glu Leu Lys Leu Met Met Glu Lys Leu Gly Ala Pro Gln 
        115                 120                 125             


Thr His Leu Gly Leu Lys Asn Met Ile Lys Glu Val Asp Glu Asp Phe 
    130                 135                 140                 


Asp Ser Lys Leu Ser Phe Arg Glu Phe Leu Leu Ile Phe Arg Lys Ala 
145                 150                 155                 160 


Ala Ala Gly Glu Leu Gln Glu Asp Ser Gly Leu Cys Val Leu Ala Arg 
                165                 170                 175     


Leu Ser Glu Ile Asp Val Ser Ser Glu Gly Val Lys Gly Ala Lys Ser 
            180                 185                 190         


Phe Phe Glu Ala Lys Val Gln Ala Ile Asn Val Ser Ser Arg Phe Glu 
        195                 200                 205             


Glu Glu Ile Lys Ala Glu Gln Glu Glu Arg Lys Lys Gln Ala Glu Glu 
    210                 215                 220                 


Met Lys Gln Arg Lys Ala Ala Phe Lys Glu Leu Gln Ser Thr Phe Lys 
225                 230                 235                 240 


<210>  25
<211>  917
<212>  DNA
<213>  Homosapiens

<400>  25
cagccagtcc tgagcaccta accatgttgg gcatcactgt cctcgctgcg ctcttggcct     60

gtgcctccag ctgtggggtg cccagcttcc cgcccaacct atccgcccga gtggtgggag    120

gagaggatgc ccggccccac agctggccct ggcagatctc cctccagtac ctcaagaacg    180

acacgtggag gcatacgtgt ggcgggactt tgattgctag caacttcgtc ctcactgccg    240

cccactgcat cagcaacacc cggacctacc gtgtggccgt gggaaagaac aacctggagg    300

tggaagacga agaaggatcc ctgtttgtgg gtgtggacac catccacgtc cacaagagat    360

ggaatgccct cctgttgcgc aatgatattg ccctcatcaa gcttgcagag catgtggagc    420

tgagtgacac catccaggtg gcctgcctgc cagagaagga ctccctgctc cccaaggact    480

acccctgcta tgtcaccggc tggggccgcc tctggaccaa cggccccatt gctgataagc    540

tgcagcaggg cctgcagccc gtggtggatc acgccacgtg ctccaggatt gactggtggg    600

gcttcagggt gaagaaaacc atggtgtgcg ctgggggcga tggcgtcatc tcagcctgca    660

atggggactc cggtggccca ctgaactgcc agttggagaa cggttcctgg gaggtgtttg    720

gcatcgtcag ctttggctcc cggcggggct gcaacacccg caagaagccg gtagtctaca    780

cccgggtgtc cgcctacatc gactggatca acgagaaaat gcagctgtga tttgttgctg    840

ggagcggcgg cagcgagtcc ctgcaacagc aataaacttc cttctcctcg ggccacctga    900

aaaaaaaaaa aaaaaaa                                                   917


<210>  26
<211>  268
<212>  PRT
<213>  Homosapiens

<400>  26

Met Leu Gly Ile Thr Val Leu Ala Ala Leu Leu Ala Cys Ala Ser Ser 
1               5                   10                  15      


Cys Gly Val Pro Ser Phe Pro Pro Asn Leu Ser Ala Arg Val Val Gly 
            20                  25                  30          


Gly Glu Asp Ala Arg Pro His Ser Trp Pro Trp Gln Ile Ser Leu Gln 
        35                  40                  45              


Tyr Leu Lys Asn Asp Thr Trp Arg His Thr Cys Gly Gly Thr Leu Ile 
    50                  55                  60                  


Ala Ser Asn Phe Val Leu Thr Ala Ala His Cys Ile Ser Asn Thr Arg 
65                  70                  75                  80  


Thr Tyr Arg Val Ala Val Gly Lys Asn Asn Leu Glu Val Glu Asp Glu 
                85                  90                  95      


Glu Gly Ser Leu Phe Val Gly Val Asp Thr Ile His Val His Lys Arg 
            100                 105                 110         


Trp Asn Ala Leu Leu Leu Arg Asn Asp Ile Ala Leu Ile Lys Leu Ala 
        115                 120                 125             


Glu His Val Glu Leu Ser Asp Thr Ile Gln Val Ala Cys Leu Pro Glu 
    130                 135                 140                 


Lys Asp Ser Leu Leu Pro Lys Asp Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Trp Thr Asn Gly Pro Ile Ala Asp Lys Leu Gln Gln Gly 
                165                 170                 175     


Leu Gln Pro Val Val Asp His Ala Thr Cys Ser Arg Ile Asp Trp Trp 
            180                 185                 190         


Gly Phe Arg Val Lys Lys Thr Met Val Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Ser Ala Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Leu 
    210                 215                 220                 


Glu Asn Gly Ser Trp Glu Val Phe Gly Ile Val Ser Phe Gly Ser Arg 
225                 230                 235                 240 


Arg Gly Cys Asn Thr Arg Lys Lys Pro Val Val Tyr Thr Arg Val Ser 
                245                 250                 255     


Ala Tyr Ile Asp Trp Ile Asn Glu Lys Met Gln Leu 
            260                 265             


<210>  27
<211>  979
<212>  DNA
<213>  Homosapiens

<400>  27
cttacagaac tcccacggac acaccatgat aaggacgctg ctgctgtcca ctttggtggc     60

tggagccctc agttgtgggg accccactta cccaccttat gtgactaggg tggttggcgg    120

tgaagaagcg aggcccaaca gctggccctg gcaggtctcc ctgcagtaca gctccaatgg    180

caagtggtac cacacctgcg gagggtccct gatagccaac agctgggtcc tgacggctgc    240

ccactgcatc agctcctcca ggacctaccg cgtggggctg ggccggcaca acctctacgt    300

tgcggagtcc ggctcgctgg cagtcagtgt ctctaagatt gtggtgcaca aggactggaa    360

ctccaaccaa atctccaaag ggaacgacat tgccctgctc aaactggcta accccgtctc    420

cctcaccgac aagatccagc tggcctgcct ccctcctgcc ggcaccattc tacccaacaa    480

ctacccctgc tacgtcacgg gctggggaag gctgcagacc aacggggctg ttcctgatgt    540

cctgcagcag ggccggttgc tggttgtgga ctatgccacc tgctccagct ctgcctggtg    600

gggcagcagc gtgaaaacca gtatgatctg tgctgggggt gatggcgtga tctccagctg    660

caacggagac tctggcgggc cactgaactg tcaggcgtct gacggccggt ggcaggtgca    720

cggcatcgtc agcttcgggt ctcgcctcgg ctgcaactac taccacaagc cctccgtctt    780

cacgcgggtc tccaattaca tcgactggat caattcggtg attgcaaata actaaccaaa    840

agaagtccct gggactgttt cagacttgga aaggtcacag aaggaaaata atataataaa    900

gtgacaacta tgcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaata aaaaaaaaaa    960

aaaaaaaaaa aaaaaaaaa                                                 979


<210>  28
<211>  269
<212>  PRT
<213>  Homosapiens

<400>  28

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Cys Gly Asp Pro Thr Tyr Pro Pro Tyr Val Thr Arg Val Val Gly Gly 
            20                  25                  30          


Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Ser Ser Asn Gly Lys Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser Ser Ser Arg Thr 
65                  70                  75                  80  


Tyr Arg Val Gly Leu Gly Arg His Asn Leu Tyr Val Ala Glu Ser Gly 
                85                  90                  95      


Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His Lys Asp Trp Asn 
            100                 105                 110         


Ser Asn Gln Ile Ser Lys Gly Asn Asp Ile Ala Leu Leu Lys Leu Ala 
        115                 120                 125             


Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala Cys Leu Pro Pro 
    130                 135                 140                 


Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Gln Thr Asn Gly Ala Val Pro Asp Val Leu Gln Gln Gly 
                165                 170                 175     


Arg Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser Ser Ala Trp Trp 
            180                 185                 190         


Gly Ser Ser Val Lys Thr Ser Met Ile Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Ser Ser Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Ala 
    210                 215                 220                 


Ser Asp Gly Arg Trp Gln Val His Gly Ile Val Ser Phe Gly Ser Arg 
225                 230                 235                 240 


Leu Gly Cys Asn Tyr Tyr His Lys Pro Ser Val Phe Thr Arg Val Ser 
                245                 250                 255     


Asn Tyr Ile Asp Trp Ile Asn Ser Val Ile Ala Asn Asn 
            260                 265                 


<210>  29
<211>  941
<212>  DNA
<213>  Homosapiens

<400>  29
cttacagaac tcccacggac acaccatgat taggaccctg ctgctgtcca ctttggtggc     60

tggagccctc agttgtgggg tctccactta cgcgcctgat atgtctagga tgcttggagg    120

tgaagaagcg aggcccaaca gctggccctg gcaggtctcc ctgcagtaca gctccaatgg    180

ccagtggtac cacacctgcg gagggtccct gatagccaac agctgggtcc tgacggctgc    240

ccactgcatc agctcctccg ggatctaccg cgtgatgctg ggccagcata acctctacgt    300

tgcagagtcc ggctcgctgg ccgtcagtgt ctctaagatt gtggtgcaca aggactggaa    360

ctccgaccag gtctccaaag ggaacgacat tgccctgctc aaactggcta accccgtctc    420

cctcaccgac aagatccagc tggcctgcct ccctcctgcc ggcaccattc tacccaacaa    480

ctacccctgc tacgtcacgg gctggggaag gctgcagacc aacggggctc tccctgatga    540

cctgaagcag ggccggttgc tggttgtgga ctatgccacc tgctccagct ctggctggtg    600

gggcagcacc gtgaagacga atatgatctg tgctgggggt gatggcgtga tatgcacctg    660

caacggagac tccggtgggc cgctgaactg tcaggcatct gacggccggt gggaggtgca    720

tggcatcggc agcctcacgt cggtccttgg ttgcaactac tactacaagc cctccatctt    780

cacgcgggtc tccaactaca acgactggat caattcggtg attgcaaata actaaccaaa    840

agaagtccct gggactgttt cagacttgga aaggtcacag aaggaaaata atattatata    900

aagtgacaac tatgcaaatc acaaaaaaaa aaaaaaaaaa a                        941


<210>  30
<211>  269
<212>  PRT
<213>  Homosapiens

<400>  30

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Cys Gly Val Ser Thr Tyr Ala Pro Asp Met Ser Arg Met Leu Gly Gly 
            20                  25                  30          


Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Ser Ser Asn Gly Gln Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser Ser Ser Gly Ile 
65                  70                  75                  80  


Tyr Arg Val Met Leu Gly Gln His Asn Leu Tyr Val Ala Glu Ser Gly 
                85                  90                  95      


Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His Lys Asp Trp Asn 
            100                 105                 110         


Ser Asp Gln Val Ser Lys Gly Asn Asp Ile Ala Leu Leu Lys Leu Ala 
        115                 120                 125             


Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala Cys Leu Pro Pro 
    130                 135                 140                 


Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Gln Thr Asn Gly Ala Leu Pro Asp Asp Leu Lys Gln Gly 
                165                 170                 175     


Arg Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser Ser Gly Trp Trp 
            180                 185                 190         


Gly Ser Thr Val Lys Thr Asn Met Ile Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Cys Thr Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Ala 
    210                 215                 220                 


Ser Asp Gly Arg Trp Glu Val His Gly Ile Gly Ser Leu Thr Ser Val 
225                 230                 235                 240 


Leu Gly Cys Asn Tyr Tyr Tyr Lys Pro Ser Ile Phe Thr Arg Val Ser 
                245                 250                 255     


Asn Tyr Asn Asp Trp Ile Asn Ser Val Ile Ala Asn Asn 
            260                 265                 


<210>  31
<211>  2034
<212>  DNA
<213>  Homosapiens

<400>  31
ggccctgggg cgggggcggg tcctggggac tggggcgggc ggccgaggcc cggaagcgga     60

ctgaggcggc ctggagtctt agttggctac tcgccatgga cgaagcggat cggcggctcc    120

tgcggcggtg ccggctgcgg ctggtggaag agctgcaggt ggaccagctc tgggacgccc    180

tgctgagccg cgagctgttc aggccccata tgatcgagga catccagcgg gcaggctctg    240

gatctcggcg ggatcaggcc aggcagctga tcatagatct ggagactcga gggagtcagg    300

ctcttccttt gttcatctcc tgcttagagg acacaggcca ggacatgctg gcttcgtttc    360

tgcgaactaa caggcaagca gcaaagttgt cgaagccaac cctagaaaac cttaccccag    420

tggtgctcag accagagatt cgcaaaccag aggttctcag accggaaaca cccagaccag    480

tggacattgg ttctggagga tttggtgatg tcggtgctct tgagagtttg aggggaaatg    540

cagatttggc ttacatcctg agcatggagc cctgtggcca ctgcctcatt atcaacaatg    600

tgaacttctg ccgtgagtcc gggctccgca cccgcactgg ctccaacatc gactgtgaga    660

agttgcggcg tcgcttctcc tcgctgcatt tcatggtgga ggtgaagggc gacctgactg    720

ccaagaaaat ggtgctggct ttgctggagc tggcgcagca ggaccacggt gctctggact    780

gctgcgtggt ggtcattctc tctcacggct gtcaggccag ccacctgcag ttcccagggg    840

ctgtctacgg cacagatgga tgccctgtgt cggtcgagaa gattgtgaac atcttcaatg    900

ggaccagctg ccccagcctg ggagggaagc ccaagctctt tttcatccag gcctgtggtg    960

gggagcagaa agaccatggg tttgaggtgg cctccacttc ccctgaagac gagtcccctg   1020

gcagtaaccc cgagccagat gccaccccgt tccaggaagg tttgaggacc ttcgaccagc   1080

tggacgccat atctagtttg cccacaccca gtgacatctt tgtgtcctac tctactttcc   1140

caggttttgt ttcctggagg gaccccaaga gtggctcctg gtacgttgag accctggacg   1200

acatctttga gcagtgggct cactctgaag acctgcagtc cctcctgctt agggtcgcta   1260

atgctgtttc ggtgaaaggg atttataaac agatgcctgg ttgctttaat ttcctccgga   1320

aaaaactttt ctttaaaaca tcataaggcc agggcccctc accctgcctt atcttgcacc   1380

ccaaagcttt cctgccccag gcctgaaaga ggctgaggcc tggactttcc tgcaactcaa   1440

ggactttgca gccggcacag ggtctgctct ttctctgcca gtgacagaca ggctcttagc   1500

agcttccaga ttgacgacaa gtgctgaaca gtggaggaag agggacagat gaatgccgtg   1560

gattgcacgt ggcctcttga gcagtggctg gtccagggct agtgacttgt gtcccatgat   1620

ccctgtgttg tctctagagc agggattaac ctctgcacta ctgacatgtg gggccaggtc   1680

accctttgct gtgaggctgt cctgtacatt gtgggatgtt cagcactgtc ccttgcctca   1740

atgccagtaa cgcgtcttcc tgagtggtgc caaacaaaaa ggttctcagg tgttgccaaa   1800

tatgtcctgg ggtataaaac tttcctcgcc tgacaaccac tggtctgtag ggatttttgg   1860

ctacacacaa accagtatcg ctcatagatc agcaaaccgg ggcctactag agtctgaaca   1920

gctgtaatct atgaattcta agtgaaattt taaaaattgt taatttttcc tatattgcat   1980

taattttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa         2034


<210>  32
<211>  416
<212>  PRT
<213>  Homosapiens

<400>  32

Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
    130                 135                 140                 


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
145                 150                 155                 160 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
                165                 170                 175     


Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
            180                 185                 190         


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr 
        195                 200                 205             


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
    210                 215                 220                 


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
225                 230                 235                 240 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys 
                245                 250                 255     


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys 
            260                 265                 270         


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
        275                 280                 285             


Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu 
    290                 295                 300                 


Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln 
305                 310                 315                 320 


Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro 
                325                 330                 335     


Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val 
            340                 345                 350         


Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp 
        355                 360                 365             


Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu 
    370                 375                 380                 


Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met 
385                 390                 395                 400 


Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
                405                 410                 415     


<210>  33
<211>  1584
<212>  DNA
<213>  Homosapiens

<400>  33
ggccctgggg cgggggcggg tcctggggac tggggcgggc ggccgaggcc cggaagcgga     60

ctgaggcggc ctggagtctt agttggctac tcgccatgga cgaagcggat cggcggctcc    120

tgcggcggtg ccggctgcgg ctggtggaag agctgcaggt ggaccagctc tgggacgccc    180

tgctgagccg cgagctgttc aggccccata tgatcgagga catccagcgg gcaggctctg    240

gatctcggcg ggatcaggcc aggcagctga tcatagatct ggagactcga gggagtcagg    300

ctcttccttt gttcatctcc tgcttagagg acacaggcca ggacatgctg gcttcgtttc    360

tgcgaactaa caggcaagca gcaaagttgt cgaagccaac cctagaaaac cttaccccag    420

tggtgctcag accagagatt cgcaaaccag aggttctcag accggaaaca cccagaccag    480

tggacattgg ttctggagga tttggtgatg tcgagcagaa agaccatggg tttgaggtgg    540

cctccacttc ccctgaagac gagtcccctg gcagtaaccc cgagccagat gccaccccgt    600

tccaggaagg tttgaggacc ttcgaccagc tggacgccat atctagtttg cccacaccca    660

gtgacatctt tgtgtcctac tctactttcc caggttttgt ttcctggagg gaccccaaga    720

gtggctcctg gtacgttgag accctggacg acatctttga gcagtgggct cactctgaag    780

acctgcagtc cctcctgctt agggtcgcta atgctgtttc ggtgaaaggg atttataaac    840

agatgcctgg ttgctttaat ttcctccgga aaaaactttt ctttaaaaca tcataaggcc    900

agggcccctc accctgcctt atcttgcacc ccaaagcttt cctgccccag gcctgaaaga    960

ggctgaggcc tggactttcc tgcaactcaa ggactttgca gccggcacag ggtctgctct   1020

ttctctgcca gtgacagaca ggctcttagc agcttccaga ttgacgacaa gtgctgaaca   1080

gtggaggaag agggacagat gaatgccgtg gattgcacgt ggcctcttga gcagtggctg   1140

gtccagggct agtgacttgt gtcccatgat ccctgtgttg tctctagagc agggattaac   1200

ctctgcacta ctgacatgtg gggccaggtc accctttgct gtgaggctgt cctgtacatt   1260

gtgggatgtt cagcactgtc ccttgcctca atgccagtaa cgcgtcttcc tgagtggtgc   1320

caaacaaaaa ggttctcagg tgttgccaaa tatgtcctgg ggtataaaac tttcctcgcc   1380

tgacaaccac tggtctgtag ggatttttgg ctacacacaa accagtatcg ctcatagatc   1440

agcaaaccgg ggcctactag agtctgaaca gctgtaatct atgaattcta agtgaaattt   1500

taaaaattgt taatttttcc tatattgcat taattttaaa aaaaaaaaaa aaaaaaaaaa   1560

aaaaaaaaaa aaaaaaaaaa aaaa                                          1584


<210>  34
<211>  266
<212>  PRT
<213>  Homosapiens

<400>  34

Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Glu Gln Lys Asp His 
    130                 135                 140                 


Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser 
145                 150                 155                 160 


Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe 
                165                 170                 175     


Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe 
            180                 185                 190         


Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys 
        195                 200                 205             


Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp 
    210                 215                 220                 


Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala 
225                 230                 235                 240 


Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe 
                245                 250                 255     


Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
            260                 265     


<210>  35
<211>  6035
<212>  DNA
<213>  Homosapiens

<400>  35
ctccccaggc ccaggcgagc gctggtgtgg acgggaagct cccggcccgg cgaactaact     60

ggagcacgga gctgcagccg gttgggccgg tgtactttcc cgctctggaa aggaagagaa    120

atggaagtga gaaagttgag catttcctgg cagttcttga tagttctggt tctgatcctg    180

caaattctgt ctgcgttgga ttttgaccca tacagagtcc taggggtcag ccgaacagcc    240

agtcaggctg atattaaaaa ggcttataag aagctcgccc gggaatggca tcctgacaaa    300

aacaaagatc ctggagcaga agacaagttc attcaaatca gtaaggctta cgagattctt    360

tcaaatgaag aaaagagatc aaattatgat caatatggag acgctggaga gaaccagggc    420

taccagaagc agcaacagca gcgagagtat cgcttccgcc atttccatga aaatttttat    480

tttgatgaat ccttttttca cttccctttt aattctgaac ggcgggactc aattgacgaa    540

aagtatttat tgcacttttc acattatgtg aatgaagtgg ttccagatag cttcaagaaa    600

ccctacctca tcaagatcac ctccgattgg tgctttagct gcattcatat cgagcctgtg    660

tggaaagaag tcattcaaga actggaagaa ttgggtgtag gaattggcgt ggtccatgct    720

gggtatgaga gacgcctggc ccatcaccta ggggcacaca gcacgccctc tatcctagga    780

atcattaacg ggaaaatctc cttcttccac aatgcagttg tccgtgaaaa tctgcgacaa    840

tttgtagaaa gtcttcttcc agggaacttg gtggagaaag ttacaaataa aaattacgtc    900

agattcctct ctggctggca gcaagagaat aagcctcatg tccttctgtt tgaccaaacg    960

cccattgtgc cactgttata caagttgact gcctttgcat acaaagatta tttatcattt   1020

ggatatgtat atgtgggttt gagagggacg gaagagatga caaggcggta caacatcaat   1080

atctacgccc ctaccctctt ggtctttaaa gaacatataa acaggcctgc cgatgttatc   1140

caggcccgag gtatgaagaa gcaaatcatt gacgacttca tcacccgaaa caaatatcta   1200

ttggcagcca ggctcaccag ccagaagttg ttccatgaac tctgccctgt gaaacggtcg   1260

catcgacaga ggaagtactg tgtggtttta ttgactgctg agactaccaa gttgagcaaa   1320

ccctttgagg ctttcctgtc ctttgccctg gcaaacactc aagacacagt gagatttgtg   1380

catgtctaca gcaatcggca gcaggagttt gccgacacct tactaccaga cagtgaggcg   1440

tttcaaggga aatcagcggt gtctatttta gaaaggcgca acacagcagg aagggtggtg   1500

tataaaaccc tggaagaccc ttggattggg agtgagagtg acaaatttat cctcttgggc   1560

tatctcgacc agctgcgtaa agatccagct cttctgtcct ctgaagcagt gcttcctgac   1620

ctgaccgatg aacttgcccc tgtttttctc cttcgatggt tctactctgc ttctgactac   1680

atctcagact gctgggatag catttttcac aacaactgga gggaaatgat gcccctgctg   1740

tccctgatct tctctgccct cttcatcctc ttcggcactg tcatcgttca ggctttcagc   1800

gactctaatg atgagcgaga gtcaagccct ccagaaaaag aggaagccca agagaagact   1860

gggaaaactg agccaagctt caccaaagaa aacagcagca agattcctaa aaaaggcttt   1920

gtggaggtaa ctgaactcac agatgtaaca tacaccagta acttggtacg tctgaggcca   1980

ggccacatga atgtggtcct catcctgtcg aattctacca agaccagcct actacagaaa   2040

tttgctttgg aggtctacac atttactggg agcagctgcc tacacttctc cttcctgagt   2100

ctagataaac acagagaatg gctagaatac ttactagaat ttgctcaaga tgcagctcca   2160

atcccaaacc aatatgataa gcatttcatg gagcgtgact acactggtta tgtactggct   2220

ctgaatggcc acaagaaata cttctgcctc ttcaagcccc aaaagacagt cgaagaggag   2280

gaagccatag ggtcgtgcag tgatgttgac tcttccctct acctgggtga atctcgaggg   2340

aaaccttcct gtggccttgg atccaggccc atcaaaggaa agttgagcaa gctctcttta   2400

tggatggaac gcctgctgga gggctcctta cagaggtttt atatcccatc atggcctgaa   2460

ctagactgag aggattttcc aaagagattt gaactcttca gactttttaa catgcccctg   2520

tgaacaggta ttttcaggac tcaaactacc acaatgaaca gagtatagat tttagattgc   2580

tcttctagaa ccatggctag aagaatcttt cctttgtcct gttctaacct aggaatgaaa   2640

aacaccacca gtttgaatcg cctagatgaa aatcttttcc tctgggtgtt atttttcccc   2700

actgaatgcc acaccattga aaatagactg ctcatcccct cttcctttct tgtccttgtc   2760

ccatgctcac cccaccctcc tgtcctgtgt cttggagaag cacagggctc caccctgcaa   2820

gcggcatctg gcggaccctc atgagcctgt cgtgcaggcc aggtcattgg ccccttcccc   2880

aatcccggcc ctgctgtgct gctgccatgg cgcatgctcc taactctgaa caacccacgg   2940

cagcttctag ccccgcatct ggaaaaaggc ccctttccaa gcaatctcac gtttactggt   3000

tgttctggga gtaagtggct aaatgtatat tttgggggta tcccccaaca acagtttgtt   3060

ggccacaggt tgaaaaggaa aggaataaac gggagttctg catgtgagtt ctcaagaaaa   3120

ggaaagggag gctgagcagt ggctgaagcg atgcagcctt gagacacgct gtgagcatcc   3180

catccgccgc cccagcgctg ctggtagcca ggggaggggt ctgcacagcg agaagtactg   3240

tgatgacttt gagccgttga catgtatgtc ttcagatgcc tttctgcctc tgtcgatttt   3300

agggtatgga tattaggagc cataacttgt aatcttgttc tctgaacgta gagataagct   3360

gctataaagc cagtagatgt taaactgaag agaaattatt cccacctgct atgagtcagg   3420

cttaaggaat ctcttcaata gtgtctcttt agtaaaatac caaacatgtc tttgtatcaa   3480

ggaacttaaa atttctcaac aattgtattt tgaacactgt taccctaaaa gtgctgtctc   3540

ttcaagtcat cttttgcagg aagtgagcca agatttgttc tagactccca ttttgcaaaa   3600

ggcttacttt ccacttctgg gctgtatttt gatgtctcat cttcattgtt ttcactctta   3660

acttagagct gcttcaccag tattggggtc agactggcca tcagcacctg agcgtgctga   3720

gctccaggta tagtggaccc cagggtgcct cataccagcc agttagagag catacctttt   3780

atttttcagg gcagaatgac cagtggttct gagtttgagt ttggacagct tcaaagagtg   3840

gtccgttcaa atgtcaaagc aaggtgcctt tggtggcttt gtgaagggtg aaaatcagtg   3900

atgggacatt tactaagtat ttcttttttt tttttttttt ttagttgttg agacagagtt   3960

tcactcttgt tgcccaggct ggagtgaaat ggtgcgatct cggttcaccg caacctccac   4020

atcccaggtt caagtgattc tcctgcctca gcctcctgag tagctaggat tacaggcatg   4080

tgccaccatg taattagccc ggctaatttt gtatttttag tagagacggg atttctccat   4140

gttgatcagg ctggtcatga actcctgacc tcaggtgatc tgcctgcctc agcctcccaa   4200

agtgctgctg ggattacagg cgtgagccac cactcccggc taagttagta tttctttaat   4260

cttaatgctt taaactaagc cacttggatc ctgaataatt taaatcttga gctacattgg   4320

taagtaataa attatttaag gccaggaatt cctgtagttt tcatggagtc tgtagcttta   4380

ttaaaaaata aatcactgcc aggcttcatt cttccatatg atcctctaaa aatggacact   4440

tcctctgaat gctgtatctc atggcacctg gtccaactag aaatggtcaa ggaattcatt   4500

tggctccttg atacatcagt cctcaatatt actttctagg tattttatgg ccagattgct   4560

tatatgagtg gtcttttggt ttggtagtag gtttttattt ttaatttctg tactaatgaa   4620

attcctgact ttaatttctg aaaaccaaaa actctccaag tgtatttatt tatatttttt   4680

ttaatagaga cgaggtcttg ctatgttgcc caggctggtc ccaaactcct ggcctcaagc   4740

agtccttcca ccttggcctc ccaaagtgct gggattatca atatgagcca ccatgccaga   4800

tttgttcatt tttaaacatt tttatctctt caagtcatct tttgatcttt taaaaagcac   4860

cttcaaacag ctgcaccttc catttgcact aggaaatgaa ggtagtgatg ggattggcaa   4920

tgttcctggc agatgtttca gcccaaaagc tcttctacag accggtttag agctggtgcc   4980

ctatgagaat attagggagc ttttatttta aattgaactt tacccttgtc catgcaaggc   5040

attcctcctg aatgcatcca tgaatttgtt tacttttgcg tcaaacatat gagccattgt   5100

catgctcagc ctgtgccacc attgctctgt ctgatgtatg taatcataca agacctgatt   5160

ttggttctaa cacagtggtc tttgactatc aacattgatg tttttagaga tgggttcttc   5220

tggttgatac agactatgca ttgcgtttag cagatggggt aaaactggcc taaaacaagt   5280

ctttgcagaa tacatgccaa tttccaaaaa aaaaaaaaaa tttgttgctc aggtgttgca   5340

caatttttat ctaacactga ggctatcagc tccaactaaa caacatttca gtgggtgagg   5400

ctgccctaac ttccattagg ggccatggtc tcactgccat cacttattag ccatgagaat   5460

ttggttgtag ttttcaggta ggttggtttc ttcctcattt gcagcttgtt gatacttgtt   5520

cctttttatt tattaacatc ccaatcaatt tgcagctgcc atcattacat aaatattttt   5580

ctgttataaa aagaagtgtg atctgttttt ttagtgattt cctttgtttg ggaatagaga   5640

ttggaagcac atactcagac ctgttttgtt aactagaatt ctttaaaagc tgatgccaaa   5700

catctttaca gaggaactgt agttcacatc cacctgtctg acattgtccc ctaaaaacaa   5760

gtgcagtgtg gcagctgctg aatctgtctg ttcagtttgt caaggaggat aattatgctt   5820

gggagagatc tgaaaagaag gtgaatattt tgcacttttg atactcttag gaacaaataa   5880

cttatttggc aaattgtttc ttttttatgt tttgggtgtt gtttttgttt tttgactttt   5940

tttgtattgt gaacaggcac tgaagctgat gttattttaa gattacagaa tggaaaaaga   6000

aataaactat tttaatgtct gataaaaaaa aaaac                              6035


<210>  36
<211>  782
<212>  PRT
<213>  Homosapiens

<400>  36

Met Glu Val Arg Lys Leu Ser Ile Ser Trp Gln Phe Leu Ile Val Leu 
1               5                   10                  15      


Val Leu Ile Leu Gln Ile Leu Ser Ala Leu Asp Phe Asp Pro Tyr Arg 
            20                  25                  30          


Val Leu Gly Val Ser Arg Thr Ala Ser Gln Ala Asp Ile Lys Lys Ala 
        35                  40                  45              


Tyr Lys Lys Leu Ala Arg Glu Trp His Pro Asp Lys Asn Lys Asp Pro 
    50                  55                  60                  


Gly Ala Glu Asp Lys Phe Ile Gln Ile Ser Lys Ala Tyr Glu Ile Leu 
65                  70                  75                  80  


Ser Asn Glu Glu Lys Arg Ser Asn Tyr Asp Gln Tyr Gly Asp Ala Gly 
                85                  90                  95      


Glu Asn Gln Gly Tyr Gln Lys Gln Gln Gln Gln Arg Glu Tyr Arg Phe 
            100                 105                 110         


Arg His Phe His Glu Asn Phe Tyr Phe Asp Glu Ser Phe Phe His Phe 
        115                 120                 125             


Pro Phe Asn Ser Glu Arg Arg Asp Ser Ile Asp Glu Lys Tyr Leu Leu 
    130                 135                 140                 


His Phe Ser His Tyr Val Asn Glu Val Val Pro Asp Ser Phe Lys Lys 
145                 150                 155                 160 


Pro Tyr Leu Ile Lys Ile Thr Ser Asp Trp Cys Phe Ser Cys Ile His 
                165                 170                 175     


Ile Glu Pro Val Trp Lys Glu Val Ile Gln Glu Leu Glu Glu Leu Gly 
            180                 185                 190         


Val Gly Ile Gly Val Val His Ala Gly Tyr Glu Arg Arg Leu Ala His 
        195                 200                 205             


His Leu Gly Ala His Ser Thr Pro Ser Ile Leu Gly Ile Ile Asn Gly 
    210                 215                 220                 


Lys Ile Ser Phe Phe His Asn Ala Val Val Arg Glu Asn Leu Arg Gln 
225                 230                 235                 240 


Phe Val Glu Ser Leu Leu Pro Gly Asn Leu Val Glu Lys Val Thr Asn 
                245                 250                 255     


Lys Asn Tyr Val Arg Phe Leu Ser Gly Trp Gln Gln Glu Asn Lys Pro 
            260                 265                 270         


His Val Leu Leu Phe Asp Gln Thr Pro Ile Val Pro Leu Leu Tyr Lys 
        275                 280                 285             


Leu Thr Ala Phe Ala Tyr Lys Asp Tyr Leu Ser Phe Gly Tyr Val Tyr 
    290                 295                 300                 


Val Gly Leu Arg Gly Thr Glu Glu Met Thr Arg Arg Tyr Asn Ile Asn 
305                 310                 315                 320 


Ile Tyr Ala Pro Thr Leu Leu Val Phe Lys Glu His Ile Asn Arg Pro 
                325                 330                 335     


Ala Asp Val Ile Gln Ala Arg Gly Met Lys Lys Gln Ile Ile Asp Asp 
            340                 345                 350         


Phe Ile Thr Arg Asn Lys Tyr Leu Leu Ala Ala Arg Leu Thr Ser Gln 
        355                 360                 365             


Lys Leu Phe His Glu Leu Cys Pro Val Lys Arg Ser His Arg Gln Arg 
    370                 375                 380                 


Lys Tyr Cys Val Val Leu Leu Thr Ala Glu Thr Thr Lys Leu Ser Lys 
385                 390                 395                 400 


Pro Phe Glu Ala Phe Leu Ser Phe Ala Leu Ala Asn Thr Gln Asp Thr 
                405                 410                 415     


Val Arg Phe Val His Val Tyr Ser Asn Arg Gln Gln Glu Phe Ala Asp 
            420                 425                 430         


Thr Leu Leu Pro Asp Ser Glu Ala Phe Gln Gly Lys Ser Ala Val Ser 
        435                 440                 445             


Ile Leu Glu Arg Arg Asn Thr Ala Gly Arg Val Val Tyr Lys Thr Leu 
    450                 455                 460                 


Glu Asp Pro Trp Ile Gly Ser Glu Ser Asp Lys Phe Ile Leu Leu Gly 
465                 470                 475                 480 


Tyr Leu Asp Gln Leu Arg Lys Asp Pro Ala Leu Leu Ser Ser Glu Ala 
                485                 490                 495     


Val Leu Pro Asp Leu Thr Asp Glu Leu Ala Pro Val Phe Leu Leu Arg 
            500                 505                 510         


Trp Phe Tyr Ser Ala Ser Asp Tyr Ile Ser Asp Cys Trp Asp Ser Ile 
        515                 520                 525             


Phe His Asn Asn Trp Arg Glu Met Met Pro Leu Leu Ser Leu Ile Phe 
    530                 535                 540                 


Ser Ala Leu Phe Ile Leu Phe Gly Thr Val Ile Val Gln Ala Phe Ser 
545                 550                 555                 560 


Asp Ser Asn Asp Glu Arg Glu Ser Ser Pro Pro Glu Lys Glu Glu Ala 
                565                 570                 575     


Gln Glu Lys Thr Gly Lys Thr Glu Pro Ser Phe Thr Lys Glu Asn Ser 
            580                 585                 590         


Ser Lys Ile Pro Lys Lys Gly Phe Val Glu Val Thr Glu Leu Thr Asp 
        595                 600                 605             


Val Thr Tyr Thr Ser Asn Leu Val Arg Leu Arg Pro Gly His Met Asn 
    610                 615                 620                 


Val Val Leu Ile Leu Ser Asn Ser Thr Lys Thr Ser Leu Leu Gln Lys 
625                 630                 635                 640 


Phe Ala Leu Glu Val Tyr Thr Phe Thr Gly Ser Ser Cys Leu His Phe 
                645                 650                 655     


Ser Phe Leu Ser Leu Asp Lys His Arg Glu Trp Leu Glu Tyr Leu Leu 
            660                 665                 670         


Glu Phe Ala Gln Asp Ala Ala Pro Ile Pro Asn Gln Tyr Asp Lys His 
        675                 680                 685             


Phe Met Glu Arg Asp Tyr Thr Gly Tyr Val Leu Ala Leu Asn Gly His 
    690                 695                 700                 


Lys Lys Tyr Phe Cys Leu Phe Lys Pro Gln Lys Thr Val Glu Glu Glu 
705                 710                 715                 720 


Glu Ala Ile Gly Ser Cys Ser Asp Val Asp Ser Ser Leu Tyr Leu Gly 
                725                 730                 735     


Glu Ser Arg Gly Lys Pro Ser Cys Gly Leu Gly Ser Arg Pro Ile Lys 
            740                 745                 750         


Gly Lys Leu Ser Lys Leu Ser Leu Trp Met Glu Arg Leu Leu Glu Gly 
        755                 760                 765             


Ser Leu Gln Arg Phe Tyr Ile Pro Ser Trp Pro Glu Leu Asp 
    770                 775                 780         


<210>  37
<211>  2196
<212>  DNA
<213>  Homosapiens

<400>  37
cttgatccca gggcgcccct gacctttgag ccggctcggg ttccggctct ggcgcgtgca     60

cactcgcctc gccgttcggg accagccaga tcgcggcggc ctcgcgggcg gtttggtcgg    120

tgaggtcttg gccgcgcgcg gcaatgctga ggctgctggc gtccgggtgc gcccggggcc    180

cggggcccgg cgtgggcgcg cgtcctgccg cagggctctt tcatccgggg cgccgccaga    240

gccgccaggc ttccgacgcg ccccggaacc agccccccag ccccgagttc gtggcccggc    300

cggtgggcgt ctgctccatg atgcgcctgc cggtgcagac ctcccccgag gggctggacg    360

ctgccttcat cggggtgccc ctggatactg ggacctccaa ccggcctggg gcgagattcg    420

gacctcgccg catccgggaa gaatcagtga tgcttgggac agtcaatcct agcacggggg    480

ccctcccctt ccagtccctc atggttgcag acctaggcga tgtgaatgtc aatctttaca    540

accttcagga cagctgccgg cgaattcaag aggcctatga gaaaattgta gcagctggct    600

gtattcctct gaccttgggt ggagatcaca caatcacata tcccatattg caagcgatgg    660

caaaaaagca tggcccagtg gggctgctgc acgtggatgc gcacacggac acgaccgaca    720

aggccctagg agagaagctc taccacgggg cgcccttccg ccggtgtgtg gatgagggtc    780

tcctggactg taagcgtgtg gtgcagattg gcatccgggg ctcttccacg accttggatc    840

cctacagata caaccggagc cagggcttcc gggtagtcct ggctgaagac tgctggatga    900

agtcgctggt tcctctgatg ggggaagtca ggcagcagat gggaggcaaa cccatttata    960

tcagctttga tattgacgct ctggatcctg cctatgcgcc agggacaggg acacctgaaa   1020

ttgctggtct cactcctagt caggctctgg agatcatcag gggttgtcaa ggcctgaacg   1080

tgatgggctg tgatcttgtc gaagtttcac caccgtatga tctttctggg aacacagccc   1140

tgctggcggc taacctgctg tttgagatgc tatgtgctct ccccaaagtg acaaccgtct   1200

gagtcttgtg ctcttcaaga caaaacagat tgcgtcgctg acaagttctc aagaagaact   1260

tatgagtaag cagtctgaga actaaagagt ttatgccaag aaaactttct gctgaaagtg   1320

tcattgctgg ctgtgaagtc gggataatca gtagaattct cacccaaaca gcaacatttc   1380

taaggaactt ggattaattg ggggaaaaaa aaaggagtac ttgtactgct ttgatttttt   1440

ttcctttgat gaaagatgga ggataaaggg gaagtgagga gaatttcttt caagattatc   1500

taaacattag aaacatgaca tttaaaaaaa ctatgaaata atactgtata agcattccat   1560

atttctatat cttcctttta aacatttttt tttttgagat ggagttttgc ttgtcaccca   1620

ggctggagtg caatggcatg atctcggttc attgcaacct ccgcctcccg agttcaatcg   1680

attctcctgc ctcagcctcc tgagtacctg ggattacggg tgcctgccac cacgcctggc   1740

taatttttgt atttttagtc cagacagggt ttcaccacat tggccaggct ggtcttgaac   1800

tcctgaccta aggtgatccg cccgcctcag cctccttaaa gtgctgggat tacaggcatg   1860

agccaccgca cccagccgct ttttaaaatt ttgatgatct gcttcctaga gtattgagta   1920

tcttccttta aactacagct cctcctcgga cgctgcagtg agctgagatc gcaccactgc   1980

actccagcct gggtgccaga gcaagactcc atctcaaaaa aaaaaaaaaa aaatacagct   2040

tctcctatga ggtgcttagg gctgcatctt ggttttagga ccactgtgaa cgtaagtaaa   2100

aagtataaag taacacggag agcctaatga agaaacttct tgctcagagg cctagaaggg   2160

tacacaaaat gtcttctaaa ctagaaaacc taaggc                             2196


<210>  38
<211>  352
<212>  PRT
<213>  Homosapiens

<400>  38

Met Leu Arg Leu Leu Ala Ser Gly Cys Ala Arg Gly Pro Gly Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Pro Ala Ala Gly Leu Phe His Pro Gly Arg Arg Gln 
            20                  25                  30          


Ser Arg Gln Ala Ser Asp Ala Pro Arg Asn Gln Pro Pro Ser Pro Glu 
        35                  40                  45              


Phe Val Ala Arg Pro Val Gly Val Cys Ser Met Met Arg Leu Pro Val 
    50                  55                  60                  


Gln Thr Ser Pro Glu Gly Leu Asp Ala Ala Phe Ile Gly Val Pro Leu 
65                  70                  75                  80  


Asp Thr Gly Thr Ser Asn Arg Pro Gly Ala Arg Phe Gly Pro Arg Arg 
                85                  90                  95      


Ile Arg Glu Glu Ser Val Met Leu Gly Thr Val Asn Pro Ser Thr Gly 
            100                 105                 110         


Ala Leu Pro Phe Gln Ser Leu Met Val Ala Asp Leu Gly Asp Val Asn 
        115                 120                 125             


Val Asn Leu Tyr Asn Leu Gln Asp Ser Cys Arg Arg Ile Gln Glu Ala 
    130                 135                 140                 


Tyr Glu Lys Ile Val Ala Ala Gly Cys Ile Pro Leu Thr Leu Gly Gly 
145                 150                 155                 160 


Asp His Thr Ile Thr Tyr Pro Ile Leu Gln Ala Met Ala Lys Lys His 
                165                 170                 175     


Gly Pro Val Gly Leu Leu His Val Asp Ala His Thr Asp Thr Thr Asp 
            180                 185                 190         


Lys Ala Leu Gly Glu Lys Leu Tyr His Gly Ala Pro Phe Arg Arg Cys 
        195                 200                 205             


Val Asp Glu Gly Leu Leu Asp Cys Lys Arg Val Val Gln Ile Gly Ile 
    210                 215                 220                 


Arg Gly Ser Ser Thr Thr Leu Asp Pro Tyr Arg Tyr Asn Arg Ser Gln 
225                 230                 235                 240 


Gly Phe Arg Val Val Leu Ala Glu Asp Cys Trp Met Lys Ser Leu Val 
                245                 250                 255     


Pro Leu Met Gly Glu Val Arg Gln Gln Met Gly Gly Lys Pro Ile Tyr 
            260                 265                 270         


Ile Ser Phe Asp Ile Asp Ala Leu Asp Pro Ala Tyr Ala Pro Gly Thr 
        275                 280                 285             


Gly Thr Pro Glu Ile Ala Gly Leu Thr Pro Ser Gln Ala Leu Glu Ile 
    290                 295                 300                 


Ile Arg Gly Cys Gln Gly Leu Asn Val Met Gly Cys Asp Leu Val Glu 
305                 310                 315                 320 


Val Ser Pro Pro Tyr Asp Leu Ser Gly Asn Thr Ala Leu Leu Ala Ala 
                325                 330                 335     


Asn Leu Leu Phe Glu Met Leu Cys Ala Leu Pro Lys Val Thr Thr Val 
            340                 345                 350         


<210>  39
<211>  1759
<212>  DNA
<213>  Homosapiens

<400>  39
ctcccgcagc accagccagg ccacgccgcc gcctcttccc ctgcgccccg cgcccaggcc     60

gggccgagcc gagccgagcc gggtcgggcc cgggccatgc tgctcaccgt gtactgtgtg    120

cggagggacc tctccgaggt gaccttttcc ctccaggtcg acgccgactt cgagctgcac    180

aacttccgcg cgctgtgcga gctcgagtct ggcatccccg cagccgagag ccagatcgtc    240

tatgcggaaa gacctctcac agacaaccac agatcattgg cttcttatgg cttgaaagat    300

ggggacgttg tgattttacg acagaaggag aatgcagacc ctcgacctcc agtgcagttc    360

ccaaacttac cccgaataga tttcagtagt atagctgtgc ctggcacatc aagtccccgg    420

cagcgccagc caccaggaac acagcagtcc cactcatctc ctggagaaat aacttcatct    480

cctcagggct tggacaatcc agccttgctc cgagatatgt tgctggccaa cccgcatgag    540

ctgtccttgc tgaaggaacg caatccaccc ctggcagaag ctctgctcag tggagacctt    600

gagaaatttt ctagagtcct ggtggagcag cagcaggacc gagcccggag agagcaagaa    660

aggattcgtc tgttttctgc tgatcccttt gaccttgaag ctcaggcaaa gatagaagaa    720

gatataaggc aacagaacat tgaggaaaac atgacaatag ctatggaaga ggctccggaa    780

agttttggcc aagtagtgat gctttatatt aactgcaaag tgaatggaca tcctgtgaaa    840

gcctttgttg actcaggtgc ccagatgact atcatgagcc aagcttgtgc agaaaggtgt    900

aacataatga gactggtgga ccgtcggtgg gcagggattg ccaaaggagt gggcacccag    960

aagattattg gaagggtaca tctagctcag gttcagattg aaggagattt tttgccatgt   1020

tccttctcta tacttgagga acagcccatg gacatgcttc tgggactgga catgcttaaa   1080

cggcaccagt gttccatcga cctgaagaaa aatgtactcg tgatcggcac cacaggctcc   1140

cagaccacct ttcttcctga gggagagcta ccagagtgtg cccggttggc atatggggct   1200

ggaagagagg atgtacggcc agaggagatt gcagaccaag aattagcaga agcccttcaa   1260

aaatcagcag aggatgcaga gcgtcagaag ccatgatgca tgtagtgtgt gtgtactgca   1320

gctggagtgg gccccagacc agagaaaagt ggtaaagaat ctacctcact gggaatgtca   1380

tcattaccaa cttcagatgg gtttaaccat cccgcccgtt cttcaggaca gagtcctgat   1440

gttggtaatc ctatgagtct tgctcgctct gtctctgctt cagtctgccc tatcaagccc   1500

agtgactcag atcgcattga acctaaagct gtgaaggctt tgaaggcttc agctgaattc   1560

cagctaaact ctgaaaagaa agaacatctt tctttacaag atctttctga tcatgcttcc   1620

tcagcagacc atgctccaac agaccagagt ccagctatgc ctatgcagaa ttcatccgaa   1680

gaaataactg ttgcaggtaa tctggagaaa tctgctgaaa gaagcaccca gggcctcaaa   1740

tttcatctcc atacaagac                                                1759


<210>  40
<211>  399
<212>  PRT
<213>  Homosapiens

<400>  40

Met Leu Leu Thr Val Tyr Cys Val Arg Arg Asp Leu Ser Glu Val Thr 
1               5                   10                  15      


Phe Ser Leu Gln Val Asp Ala Asp Phe Glu Leu His Asn Phe Arg Ala 
            20                  25                  30          


Leu Cys Glu Leu Glu Ser Gly Ile Pro Ala Ala Glu Ser Gln Ile Val 
        35                  40                  45              


Tyr Ala Glu Arg Pro Leu Thr Asp Asn His Arg Ser Leu Ala Ser Tyr 
    50                  55                  60                  


Gly Leu Lys Asp Gly Asp Val Val Ile Leu Arg Gln Lys Glu Asn Ala 
65                  70                  75                  80  


Asp Pro Arg Pro Pro Val Gln Phe Pro Asn Leu Pro Arg Ile Asp Phe 
                85                  90                  95      


Ser Ser Ile Ala Val Pro Gly Thr Ser Ser Pro Arg Gln Arg Gln Pro 
            100                 105                 110         


Pro Gly Thr Gln Gln Ser His Ser Ser Pro Gly Glu Ile Thr Ser Ser 
        115                 120                 125             


Pro Gln Gly Leu Asp Asn Pro Ala Leu Leu Arg Asp Met Leu Leu Ala 
    130                 135                 140                 


Asn Pro His Glu Leu Ser Leu Leu Lys Glu Arg Asn Pro Pro Leu Ala 
145                 150                 155                 160 


Glu Ala Leu Leu Ser Gly Asp Leu Glu Lys Phe Ser Arg Val Leu Val 
                165                 170                 175     


Glu Gln Gln Gln Asp Arg Ala Arg Arg Glu Gln Glu Arg Ile Arg Leu 
            180                 185                 190         


Phe Ser Ala Asp Pro Phe Asp Leu Glu Ala Gln Ala Lys Ile Glu Glu 
        195                 200                 205             


Asp Ile Arg Gln Gln Asn Ile Glu Glu Asn Met Thr Ile Ala Met Glu 
    210                 215                 220                 


Glu Ala Pro Glu Ser Phe Gly Gln Val Val Met Leu Tyr Ile Asn Cys 
225                 230                 235                 240 


Lys Val Asn Gly His Pro Val Lys Ala Phe Val Asp Ser Gly Ala Gln 
                245                 250                 255     


Met Thr Ile Met Ser Gln Ala Cys Ala Glu Arg Cys Asn Ile Met Arg 
            260                 265                 270         


Leu Val Asp Arg Arg Trp Ala Gly Ile Ala Lys Gly Val Gly Thr Gln 
        275                 280                 285             


Lys Ile Ile Gly Arg Val His Leu Ala Gln Val Gln Ile Glu Gly Asp 
    290                 295                 300                 


Phe Leu Pro Cys Ser Phe Ser Ile Leu Glu Glu Gln Pro Met Asp Met 
305                 310                 315                 320 


Leu Leu Gly Leu Asp Met Leu Lys Arg His Gln Cys Ser Ile Asp Leu 
                325                 330                 335     


Lys Lys Asn Val Leu Val Ile Gly Thr Thr Gly Ser Gln Thr Thr Phe 
            340                 345                 350         


Leu Pro Glu Gly Glu Leu Pro Glu Cys Ala Arg Leu Ala Tyr Gly Ala 
        355                 360                 365             


Gly Arg Glu Asp Val Arg Pro Glu Glu Ile Ala Asp Gln Glu Leu Ala 
    370                 375                 380                 


Glu Ala Leu Gln Lys Ser Ala Glu Asp Ala Glu Arg Gln Lys Pro 
385                 390                 395                 


<210>  41
<211>  1854
<212>  DNA
<213>  Homosapiens

<400>  41
atgtcatcat taccaacttc agatgggttt aaccatcccg cccgttcttc aggacagagt     60

cctgatgttg gtaatcctat gagtcttgct cgctctgtct ctgcttcagt ctgccctatc    120

aagcccagtg actcagatcg cattgaacct aaagctgtga aggctttgaa ggcttcagct    180

gaattccagc taaactctga aaagaaagaa catctttctt tacaagatct ttctgatcat    240

gcttcctcag cagaccatgc tccaacagac cagagtccag ctatgcctat gcagaattca    300

tccgaagaaa taactgttgc aggtaatctg gagaaatctg ctgaaagaag cacccagggc    360

ctcaaatttc atctccatac aagacaggaa gctagtttat ctgtcacatc tactaggatg    420

catgaaccac agatgtttct aggtgaaaag gattggcatc cagaaaatca gaacctgagt    480

caagtgagtg accctcagca gcacgaagaa ccagggaatg aacagtatga ggttgcacaa    540

caaaaagctt cacatgacca agaatatctt tgtaacatag gggaccttga gcttcctgaa    600

gaaaggcaac agaatcaaca caaaattgtt gatttggaag ctacgatgaa aggaaatggg    660

ctcccacaga atgtggatcc tccaagtgcg aagaaaagta ttccatcttc agaatgcagt    720

ggctgctcaa attcagaaac atttatggaa atcgatacag ctcaacagtc cctagttact    780

ttgcttaatt caacaggcag gcagaatgcc aatgtcaaga acattggtgc attggatctc    840

actttagata atcccttgat ggaagtagaa acatcaaaat gtaacccttc atctgaaatt    900

ttgaatgatt ccatttccac tcaggattta cagcccccag aaactaatgt tgaaatacct    960

ggaacaaata aagaatatgg ccattactcc tctccaagtc tctgtggcag ttgtcagcct   1020

tctgtggagt cagcagaaga atcttgcccg tctataacgg cagccttgaa agaacttcat   1080

gaacttttgg ttgttagcag taaaccagct tcagaaaata catctgaaga agtaatctgt   1140

caatcagaaa ccatagctga gggccaaacc agtattaaag acctttctga aagatggacc   1200

caaaatgagc atcttaccca gaatgaacag tgtccacaag tctcctttca tcaggccata   1260

tctgtatcag tggagacaga aaaattaaca ggtacttcat ctgacactgg aagagaagct   1320

gtagaaaatg taaacttcag gagtctaggt gatggcctgt caaccgataa ggaaggtgtc   1380

cccaaatcta gggaatccat aaataagaac cgttctgtca ctgtaacctc agctaaaaca   1440

tccaatcagt tacactgcac cttaggtgta gaaatttcac ccaaactttt agcaggtgag   1500

gaggatgcac tcaatcagac ttctgagcaa actaagtctt tgtcatccaa tttcatattg   1560

gttaaagact taggtcaggg catacagaat tcagtaacag acaggcctga aaccagagaa   1620

aatgtctgtc ctgatgcttc gaggccatta cttgaatatg aaccacctac cagccatcca   1680

tcatcaagtc ctgccattct tccaccattg atttttcctg ccacagatat tgaccgcatt   1740

ctccgtgctg gctttacttt gcaggaagct cttggagctt tgcatcgagt tggtgggaat   1800

gcagaccttg cacttcttgt tttgctcgca aaaaacatcg tagttcctac atga         1854


<210>  42
<211>  617
<212>  PRT
<213>  Homosapiens

<400>  42

Met Ser Ser Leu Pro Thr Ser Asp Gly Phe Asn His Pro Ala Arg Ser 
1               5                   10                  15      


Ser Gly Gln Ser Pro Asp Val Gly Asn Pro Met Ser Leu Ala Arg Ser 
            20                  25                  30          


Val Ser Ala Ser Val Cys Pro Ile Lys Pro Ser Asp Ser Asp Arg Ile 
        35                  40                  45              


Glu Pro Lys Ala Val Lys Ala Leu Lys Ala Ser Ala Glu Phe Gln Leu 
    50                  55                  60                  


Asn Ser Glu Lys Lys Glu His Leu Ser Leu Gln Asp Leu Ser Asp His 
65                  70                  75                  80  


Ala Ser Ser Ala Asp His Ala Pro Thr Asp Gln Ser Pro Ala Met Pro 
                85                  90                  95      


Met Gln Asn Ser Ser Glu Glu Ile Thr Val Ala Gly Asn Leu Glu Lys 
            100                 105                 110         


Ser Ala Glu Arg Ser Thr Gln Gly Leu Lys Phe His Leu His Thr Arg 
        115                 120                 125             


Gln Glu Ala Ser Leu Ser Val Thr Ser Thr Arg Met His Glu Pro Gln 
    130                 135                 140                 


Met Phe Leu Gly Glu Lys Asp Trp His Pro Glu Asn Gln Asn Leu Ser 
145                 150                 155                 160 


Gln Val Ser Asp Pro Gln Gln His Glu Glu Pro Gly Asn Glu Gln Tyr 
                165                 170                 175     


Glu Val Ala Gln Gln Lys Ala Ser His Asp Gln Glu Tyr Leu Cys Asn 
            180                 185                 190         


Ile Gly Asp Leu Glu Leu Pro Glu Glu Arg Gln Gln Asn Gln His Lys 
        195                 200                 205             


Ile Val Asp Leu Glu Ala Thr Met Lys Gly Asn Gly Leu Pro Gln Asn 
    210                 215                 220                 


Val Asp Pro Pro Ser Ala Lys Lys Ser Ile Pro Ser Ser Glu Cys Ser 
225                 230                 235                 240 


Gly Cys Ser Asn Ser Glu Thr Phe Met Glu Ile Asp Thr Ala Gln Gln 
                245                 250                 255     


Ser Leu Val Thr Leu Leu Asn Ser Thr Gly Arg Gln Asn Ala Asn Val 
            260                 265                 270         


Lys Asn Ile Gly Ala Leu Asp Leu Thr Leu Asp Asn Pro Leu Met Glu 
        275                 280                 285             


Val Glu Thr Ser Lys Cys Asn Pro Ser Ser Glu Ile Leu Asn Asp Ser 
    290                 295                 300                 


Ile Ser Thr Gln Asp Leu Gln Pro Pro Glu Thr Asn Val Glu Ile Pro 
305                 310                 315                 320 


Gly Thr Asn Lys Glu Tyr Gly His Tyr Ser Ser Pro Ser Leu Cys Gly 
                325                 330                 335     


Ser Cys Gln Pro Ser Val Glu Ser Ala Glu Glu Ser Cys Pro Ser Ile 
            340                 345                 350         


Thr Ala Ala Leu Lys Glu Leu His Glu Leu Leu Val Val Ser Ser Lys 
        355                 360                 365             


Pro Ala Ser Glu Asn Thr Ser Glu Glu Val Ile Cys Gln Ser Glu Thr 
    370                 375                 380                 


Ile Ala Glu Gly Gln Thr Ser Ile Lys Asp Leu Ser Glu Arg Trp Thr 
385                 390                 395                 400 


Gln Asn Glu His Leu Thr Gln Asn Glu Gln Cys Pro Gln Val Ser Phe 
                405                 410                 415     


His Gln Ala Ile Ser Val Ser Val Glu Thr Glu Lys Leu Thr Gly Thr 
            420                 425                 430         


Ser Ser Asp Thr Gly Arg Glu Ala Val Glu Asn Val Asn Phe Arg Ser 
        435                 440                 445             


Leu Gly Asp Gly Leu Ser Thr Asp Lys Glu Gly Val Pro Lys Ser Arg 
    450                 455                 460                 


Glu Ser Ile Asn Lys Asn Arg Ser Val Thr Val Thr Ser Ala Lys Thr 
465                 470                 475                 480 


Ser Asn Gln Leu His Cys Thr Leu Gly Val Glu Ile Ser Pro Lys Leu 
                485                 490                 495     


Leu Ala Gly Glu Glu Asp Ala Leu Asn Gln Thr Ser Glu Gln Thr Lys 
            500                 505                 510         


Ser Leu Ser Ser Asn Phe Ile Leu Val Lys Asp Leu Gly Gln Gly Ile 
        515                 520                 525             


Gln Asn Ser Val Thr Asp Arg Pro Glu Thr Arg Glu Asn Val Cys Pro 
    530                 535                 540                 


Asp Ala Ser Arg Pro Leu Leu Glu Tyr Glu Pro Pro Thr Ser His Pro 
545                 550                 555                 560 


Ser Ser Ser Pro Ala Ile Leu Pro Pro Leu Ile Phe Pro Ala Thr Asp 
                565                 570                 575     


Ile Asp Arg Ile Leu Arg Ala Gly Phe Thr Leu Gln Glu Ala Leu Gly 
            580                 585                 590         


Ala Leu His Arg Val Gly Gly Asn Ala Asp Leu Ala Leu Leu Val Leu 
        595                 600                 605             


Leu Ala Lys Asn Ile Val Val Pro Thr 
    610                 615         


<210>  43
<211>  4153
<212>  DNA
<213>  Homosapiens

<400>  43
atggcctttt cctacctgtt tgccacctgt gcccgcggcc tccttccccg ccggccgcgc     60

tccggagcct ccgggccgcg gtggagcgag ggcccaggcg aggcgagggc cgggcggcgg    120

gcgccgggcc ccgcggccgg cacgacggag cccccgtacg gccggcggca gcggttggcg    180

gcggcccccg gcccccggcg cgggaagcgg cggcggggcg gcggcggcgg tggcggtggc    240

ggtggcggcg acggtggcag cgccatggag ccgggggagg tgaaggaccg gatcctggag    300

aacatctcgc tgtcggtgaa gaagttgcag agctattttg ctgcatgtga ggatgagatc    360

cctgccatcc ggaaccatga caaggtccta cagcgtctgt gtgagcacct ggaccacgcc    420

ctgctgtacg gactgcaaga cctctcctct ggctactggg tgctcgtggt gcattttact    480

cggagagagg ccatcaagca gatcgaggtg ctgcagcacg tggccaccaa cctggggcgc    540

agccgtgcct ggctgtacct ggccctcaac gagaactcct tggagagcta cctgcggttg    600

ttccaggaga acctgggcct gctgcataag tactacgtca agaatgccct ggtctgcagc    660

cacgatcacc tgacgctctt cctgaccttg gtgtccgggc tagagttcat tcgtttcgag    720

ctggatctgg atgcccctta cctagacctg gccccctaca tgcccgacta ctacaaacct    780

cagtacctgc tggactttga agaccgcctt cccagctcgg tccacggctc agacagtctg    840

tccctcaact ctttcaactc cgtcacctcc accaacctgg agtgggatga cagtgcgatt    900

gccccatcta gtgaggatta tgattttgga gatgtgtttc cagcagtgcc gtctgtaccc    960

agcacagact gggaagatgg agacctcaca gacacggtca gtggtccccg ctccacagcc   1020

tccgacctga ccagcagcaa ggcctccacc aggagcccca cccagcgcca gaaccccttc   1080

aacgaggagc cggcagagac tgtgtcctcc tctgacacca cccccgtgca caccacctct   1140

caggagaagg aggaggccca ggccctggac ccgccggatg cctgcacgga gctcgaggtc   1200

atcagggtca ccaagaagaa gaaaattggc aagaagaaaa agagcagatc agatgaggag   1260

gcaagtccac tccaccccgc ctgcagccag aagaaatgtg ccaagcaggg ggacggtgac   1320

agccgcaacg gcagcccaag ccttgggcgg gactcgccag acactatgct tgcctccccc   1380

caggaggagg gagaggggcc gagcagcacc acggagagca gcgagcgctc cgagccgggc   1440

ctgctgatcc ctgagatgaa ggacacctcc atggagcgct tggggcagcc cctgagcaag   1500

gttatcgacc agctcaacgg gcagctggac cccagcacct ggtgctcccg tgctgagccc   1560

ccagaccagt cctttcggac cggctctccc ggggatgccc cggagaggcc gccgctttgc   1620

gactttagtg aggggctttc agccccaatg gacttctacc gctttaccgt cgagagtcca   1680

agcactgtta catcaggtgg cggccaccat gaccctgcag ggcttggcca accgctgcat   1740

gttcctagta gccctgaggc tgctggccaa gaagaagagg gaggaggagg agagggacag   1800

acgcctcggc ccctagagga taccacgagg gaggctcagg agctggaggc ccagctgtcc   1860

ctggtcaggg aggggcctgt gtctgagcca gagcctggga cccaggaggt tctctgccag   1920

ctcaagcgag accagcccag cccgtgtctg agtagcgctg aggattctgg ggtggatgag   1980

ggacagggga gcccttcgga gatggtccat tcctcggagt tcagagtaga caacaatcac   2040

ctgctcctgc tcatgatcca cgtgttccga gaaaacgaag agcagctgtt caaaatgatc   2100

cggatgagca ccgggcacat ggagggcaac ctgcagctgc tgtacgtgct gctcacagac   2160

tgctatgtct acctgctccg gaaaggggcc acagagaagc catacctggt ggaagaggcc   2220

gtttcttaca atgaacttga ctatgtgtcg gttggccttg accagcagac ggtgaagctg   2280

gtgtgcacca accgcaggaa gcagtttctg ctggacacgg ctgatgtggc gctggctgag   2340

ttctttttgg cttctttgaa gtcagccatg atcaaaggct gtcgagaacc tccctacccc   2400

agcatcctga cggatgccac catggagaag ctggcactgg ccaaatttgt ggcccaagaa   2460

tcgaagtgtg aggcatctgc tgtcaccgtg cgcttctacg gccttgtgca ctgggaggac   2520

cccacagacg agtccctggg ccccacgccc tgccactgct caccccccga gggcaccatc   2580

accaaagaag gcatgctgca ctacaaggcg ggcacctcct acctgggcaa ggaacactgg   2640

aagacgtgct tcgtggtgct cagcaacggg atcctctacc agtacccgga ccgcaccgac   2700

gtcatccctc tgctctcggt gaacatgggg ggggagcagt gcggtggctg ccggagagcc   2760

aacaccacgg atcggcccca cgccttccag gtcattctct ccgaccggcc ctgcctggag   2820

ctaagtgccg agagcgaggc cgagatggcc gagtggatgc agcatctctg ccaggctgtg   2880

tccaaagggg tcatccccca gggcgtagct cccagcccct gcataccctg ctgcctggtc   2940

ctcacggatg accgcctctt tacgtgccat gaggattgcc agaccagctt cttccgctct   3000

ttgggcacag ccaagctggg cgacatcagc gccgtctcca ccgagccggg caaggagtac   3060

tgcgtcttgg agttctccca ggacagccag cagctcctcc cgccctgggt catctacctg   3120

agctgcactt ctgaactgga ccgattgctg tctgcactga actctgggtg gaaaaccatc   3180

tatcaggtgg acctccccca cacggcgatc caggaagcct ccaacaagaa gaaattcgag   3240

gatgccttga gcctcatcca cagcgcctgg cagcggagcg acagtctctg ccgcggccga   3300

gcctcccgag acccctggtg ctgaggcaga gctggttggc gtccctggtg ggcaggaaag   3360

gaaggcacgc cagccggcag gcacactgtc acggctgttg tcatgctgtc gggagcctac   3420

agtccacccc tgccctgggc ggcagaacca ccgagtgtgg cttaagacag ggtccctcca   3480

ctccagggat ccagatcagg tgcccggcac ccctgggcat cctgcccgac aggtagcgaa   3540

tggaggtcgc tgggggcaga gggtccgagc cctgtgggct ctgcggatgc acgccctcct   3600

cccgggcctc cgcctcagtc tgcagaattt ctgccgagtg gcaccgagaa caccatccat   3660

ctaaggacga acaaaagaac caggagggcg ggacccccct cttcctctcc tgggttgggg   3720

gctggggccc tgagtgccca gccatccttg ttcgtgtttg aacactctcc tggccacgtg   3780

gggaagcggg aacacggggt gtctgcgcat gtttcctcct cctagctcca tcactgcgca   3840

cacagctgcc tgcctcgcca gatgcagggg ggcgggcagc cctccctggc tgccaggagg   3900

ctctgcatgc ccacagtcct gccctgcctg tcccctcaac ccggcagtgc ctgtagcacc   3960

gaggagcaaa gggggtggat ggggggcttg gagaagggcg gagcccacca gcctggcatc   4020

catgttgaca tcttctgact gtcccctgct tggctggagc caggcccttc cctagagttt   4080

cgtcaagagc ctcctgggga aggggtcagg tggtttgggt tttgtttttt aaaataaaat   4140

agacatgtta tat                                                      4153


<210>  44
<211>  1107
<212>  PRT
<213>  Homosapiens

<400>  44

Met Ala Phe Ser Tyr Leu Phe Ala Thr Cys Ala Arg Gly Leu Leu Pro 
1               5                   10                  15      


Arg Arg Pro Arg Ser Gly Ala Ser Gly Pro Arg Trp Ser Glu Gly Pro 
            20                  25                  30          


Gly Glu Ala Arg Ala Gly Arg Arg Ala Pro Gly Pro Ala Ala Gly Thr 
        35                  40                  45              


Thr Glu Pro Pro Tyr Gly Arg Arg Gln Arg Leu Ala Ala Ala Pro Gly 
    50                  55                  60                  


Pro Arg Arg Gly Lys Arg Arg Arg Gly Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Asp Gly Gly Ser Ala Met Glu Pro Gly Glu Val Lys Asp 
                85                  90                  95      


Arg Ile Leu Glu Asn Ile Ser Leu Ser Val Lys Lys Leu Gln Ser Tyr 
            100                 105                 110         


Phe Ala Ala Cys Glu Asp Glu Ile Pro Ala Ile Arg Asn His Asp Lys 
        115                 120                 125             


Val Leu Gln Arg Leu Cys Glu His Leu Asp His Ala Leu Leu Tyr Gly 
    130                 135                 140                 


Leu Gln Asp Leu Ser Ser Gly Tyr Trp Val Leu Val Val His Phe Thr 
145                 150                 155                 160 


Arg Arg Glu Ala Ile Lys Gln Ile Glu Val Leu Gln His Val Ala Thr 
                165                 170                 175     


Asn Leu Gly Arg Ser Arg Ala Trp Leu Tyr Leu Ala Leu Asn Glu Asn 
            180                 185                 190         


Ser Leu Glu Ser Tyr Leu Arg Leu Phe Gln Glu Asn Leu Gly Leu Leu 
        195                 200                 205             


His Lys Tyr Tyr Val Lys Asn Ala Leu Val Cys Ser His Asp His Leu 
    210                 215                 220                 


Thr Leu Phe Leu Thr Leu Val Ser Gly Leu Glu Phe Ile Arg Phe Glu 
225                 230                 235                 240 


Leu Asp Leu Asp Ala Pro Tyr Leu Asp Leu Ala Pro Tyr Met Pro Asp 
                245                 250                 255     


Tyr Tyr Lys Pro Gln Tyr Leu Leu Asp Phe Glu Asp Arg Leu Pro Ser 
            260                 265                 270         


Ser Val His Gly Ser Asp Ser Leu Ser Leu Asn Ser Phe Asn Ser Val 
        275                 280                 285             


Thr Ser Thr Asn Leu Glu Trp Asp Asp Ser Ala Ile Ala Pro Ser Ser 
    290                 295                 300                 


Glu Asp Tyr Asp Phe Gly Asp Val Phe Pro Ala Val Pro Ser Val Pro 
305                 310                 315                 320 


Ser Thr Asp Trp Glu Asp Gly Asp Leu Thr Asp Thr Val Ser Gly Pro 
                325                 330                 335     


Arg Ser Thr Ala Ser Asp Leu Thr Ser Ser Lys Ala Ser Thr Arg Ser 
            340                 345                 350         


Pro Thr Gln Arg Gln Asn Pro Phe Asn Glu Glu Pro Ala Glu Thr Val 
        355                 360                 365             


Ser Ser Ser Asp Thr Thr Pro Val His Thr Thr Ser Gln Glu Lys Glu 
    370                 375                 380                 


Glu Ala Gln Ala Leu Asp Pro Pro Asp Ala Cys Thr Glu Leu Glu Val 
385                 390                 395                 400 


Ile Arg Val Thr Lys Lys Lys Lys Ile Gly Lys Lys Lys Lys Ser Arg 
                405                 410                 415     


Ser Asp Glu Glu Ala Ser Pro Leu His Pro Ala Cys Ser Gln Lys Lys 
            420                 425                 430         


Cys Ala Lys Gln Gly Asp Gly Asp Ser Arg Asn Gly Ser Pro Ser Leu 
        435                 440                 445             


Gly Arg Asp Ser Pro Asp Thr Met Leu Ala Ser Pro Gln Glu Glu Gly 
    450                 455                 460                 


Glu Gly Pro Ser Ser Thr Thr Glu Ser Ser Glu Arg Ser Glu Pro Gly 
465                 470                 475                 480 


Leu Leu Ile Pro Glu Met Lys Asp Thr Ser Met Glu Arg Leu Gly Gln 
                485                 490                 495     


Pro Leu Ser Lys Val Ile Asp Gln Leu Asn Gly Gln Leu Asp Pro Ser 
            500                 505                 510         


Thr Trp Cys Ser Arg Ala Glu Pro Pro Asp Gln Ser Phe Arg Thr Gly 
        515                 520                 525             


Ser Pro Gly Asp Ala Pro Glu Arg Pro Pro Leu Cys Asp Phe Ser Glu 
    530                 535                 540                 


Gly Leu Ser Ala Pro Met Asp Phe Tyr Arg Phe Thr Val Glu Ser Pro 
545                 550                 555                 560 


Ser Thr Val Thr Ser Gly Gly Gly His His Asp Pro Ala Gly Leu Gly 
                565                 570                 575     


Gln Pro Leu His Val Pro Ser Ser Pro Glu Ala Ala Gly Gln Glu Glu 
            580                 585                 590         


Glu Gly Gly Gly Gly Glu Gly Gln Thr Pro Arg Pro Leu Glu Asp Thr 
        595                 600                 605             


Thr Arg Glu Ala Gln Glu Leu Glu Ala Gln Leu Ser Leu Val Arg Glu 
    610                 615                 620                 


Gly Pro Val Ser Glu Pro Glu Pro Gly Thr Gln Glu Val Leu Cys Gln 
625                 630                 635                 640 


Leu Lys Arg Asp Gln Pro Ser Pro Cys Leu Ser Ser Ala Glu Asp Ser 
                645                 650                 655     


Gly Val Asp Glu Gly Gln Gly Ser Pro Ser Glu Met Val His Ser Ser 
            660                 665                 670         


Glu Phe Arg Val Asp Asn Asn His Leu Leu Leu Leu Met Ile His Val 
        675                 680                 685             


Phe Arg Glu Asn Glu Glu Gln Leu Phe Lys Met Ile Arg Met Ser Thr 
    690                 695                 700                 


Gly His Met Glu Gly Asn Leu Gln Leu Leu Tyr Val Leu Leu Thr Asp 
705                 710                 715                 720 


Cys Tyr Val Tyr Leu Leu Arg Lys Gly Ala Thr Glu Lys Pro Tyr Leu 
                725                 730                 735     


Val Glu Glu Ala Val Ser Tyr Asn Glu Leu Asp Tyr Val Ser Val Gly 
            740                 745                 750         


Leu Asp Gln Gln Thr Val Lys Leu Val Cys Thr Asn Arg Arg Lys Gln 
        755                 760                 765             


Phe Leu Leu Asp Thr Ala Asp Val Ala Leu Ala Glu Phe Phe Leu Ala 
    770                 775                 780                 


Ser Leu Lys Ser Ala Met Ile Lys Gly Cys Arg Glu Pro Pro Tyr Pro 
785                 790                 795                 800 


Ser Ile Leu Thr Asp Ala Thr Met Glu Lys Leu Ala Leu Ala Lys Phe 
                805                 810                 815     


Val Ala Gln Glu Ser Lys Cys Glu Ala Ser Ala Val Thr Val Arg Phe 
            820                 825                 830         


Tyr Gly Leu Val His Trp Glu Asp Pro Thr Asp Glu Ser Leu Gly Pro 
        835                 840                 845             


Thr Pro Cys His Cys Ser Pro Pro Glu Gly Thr Ile Thr Lys Glu Gly 
    850                 855                 860                 


Met Leu His Tyr Lys Ala Gly Thr Ser Tyr Leu Gly Lys Glu His Trp 
865                 870                 875                 880 


Lys Thr Cys Phe Val Val Leu Ser Asn Gly Ile Leu Tyr Gln Tyr Pro 
                885                 890                 895     


Asp Arg Thr Asp Val Ile Pro Leu Leu Ser Val Asn Met Gly Gly Glu 
            900                 905                 910         


Gln Cys Gly Gly Cys Arg Arg Ala Asn Thr Thr Asp Arg Pro His Ala 
        915                 920                 925             


Phe Gln Val Ile Leu Ser Asp Arg Pro Cys Leu Glu Leu Ser Ala Glu 
    930                 935                 940                 


Ser Glu Ala Glu Met Ala Glu Trp Met Gln His Leu Cys Gln Ala Val 
945                 950                 955                 960 


Ser Lys Gly Val Ile Pro Gln Gly Val Ala Pro Ser Pro Cys Ile Pro 
                965                 970                 975     


Cys Cys Leu Val Leu Thr Asp Asp Arg Leu Phe Thr Cys His Glu Asp 
            980                 985                 990         


Cys Gln Thr Ser Phe Phe Arg Ser  Leu Gly Thr Ala Lys  Leu Gly Asp 
        995                 1000                 1005             


Ile Ser  Ala Val Ser Thr Glu  Pro Gly Lys Glu Tyr  Cys Val Leu 
    1010                 1015                 1020             


Glu Phe  Ser Gln Asp Ser Gln  Gln Leu Leu Pro Pro  Trp Val Ile 
    1025                 1030                 1035             


Tyr Leu  Ser Cys Thr Ser Glu  Leu Asp Arg Leu Leu  Ser Ala Leu 
    1040                 1045                 1050             


Asn Ser  Gly Trp Lys Thr Ile  Tyr Gln Val Asp Leu  Pro His Thr 
    1055                 1060                 1065             


Ala Ile  Gln Glu Ala Ser Asn  Lys Lys Lys Phe Glu  Asp Ala Leu 
    1070                 1075                 1080             


Ser Leu  Ile His Ser Ala Trp  Gln Arg Ser Asp Ser  Leu Cys Arg 
    1085                 1090                 1095             


Gly Arg  Ala Ser Arg Asp Pro  Trp Cys 
    1100                 1105         


<210>  45
<211>  3172
<212>  DNA
<213>  Homosapiens

<400>  45
caggcagcca caggcctgtc agaccaggac ccttaccctc tagacatggc ctcggtcccc     60

tgcaaacccc agccccgtag ccctgcgagg ttacagacag cctaaacgcc accaccacag    120

ggcctgtgcc gtgcccctga cccgggcaca gaaggccact ggcccggagg ccatggagac    180

ggtgccccca gcagtggacc tggtgctggg tgcttctgcc tgctgcctgg cctgtgtctt    240

caccaacccc ctggaggtgg tgaagacgcg gctgcagctg cagggggagc tgcaggcccg    300

gggcacctac ccacggccct accatggctt catagcctct gtcgctgctg tggcccgagc    360

agacgggctg tggggcctgc agaaggggct ggctgccggc cttctgtacc aaggcctcat    420

gaatggcgtt cgtttctact gctacagcct ggcgtgccag gctggcctca cgcagcaacc    480

aggtggcacc gtggttgcgg gagccgtggc gggggcactg ggagccttcg tggggagccc    540

tgcttacctg atcaaaacgc agctgcaagc tcagacagtg gccgcagtgg ccgtgggaca    600

ccagcacaat caccagactg tcctgggtgc cttggagacc atctggcggc agcaagggct    660

cttggggctg tggcagggcg ttggtggggc tgtgccccga gtcatggtgg gctcagctgc    720

ccagctggcc accttcgcct ctgccaaggc ctgggtacag aagcaacagt ggctccctga    780

ggacagctgg ctggtggccc tggctggggg catgatcagc agcatagccg tggttgtcgt    840

catgactccc ttcgatgtgg tcagcacgcg gctatacaat cagccggtgg acacagctgg    900

caggggccag ctctatgggg gcctcaccga ctgcatggtg aagatctggc ggcaggaggg    960

ccccctggca ctctacaagg gcctgggccc cgcctacctg cgcctgggcc cccacaccat   1020

cctcagcatg ctcttctggg acgagcttcg gaaactggct gggcgggccc agcacaaggg   1080

cacctagacg acggccctca cccccacgtc ctgacacggc cggcacttgg ccggaagtga   1140

gagcctgctc caggacaact ggctgtcccg gggcgggcca tgggcccagg ccctgccaga   1200

ggtcccggga gagtgtggac agctctggtc catccagccc cttggcccac ccaggtccag   1260

agcatccact tcaagttacc acccattctg tcttccagac agttctcttc cttctctgta   1320

ctgcgtactg ggtcaccaca tcccagagcc ttgctcagtt atagcaactg ctgcgggcgt   1380

gcacatggca taggcccagt aacttacata catcggctca cttaggcctc agacagcagc   1440

acgaggcagg cacttttact tcttttacca ttagaaagcc aaggcctaga gtggtgggct   1500

ttgaccacag ccacacaatt ttgaagtggc agagccagga ctggagctta gccctgctca   1560

ccctagacct atgcgcttga caagtgcgtg actgtgacag gcccatgggc ccggactgcc   1620

cataggggtc actgtaccat ggcaaaggct gaggtgcacc aggaggctgt ggcgtcgtca   1680

cctgccttat ttgctggaga agctgtagca aagaaccaca gactgggcga cttagacaat   1740

agaaatgtat tttctcacag ttctggaggc tggatgctgg agaccaaggt gtcagtgggc   1800

tggtttcttc tgaggcctct gtccatggct tgcagatgct gctttctctc tgtgtctgca   1860

catggtggtc cctcgatgtg cgtctgggtc ctgatctcct cctcttataa ggacacaaat   1920

catgttggct tagggcccac cctcatgacc ccactttaat tttttttttt ttttttgaga   1980

tgaagtctca ctctgccacc caagctggag tgcagtggca cgatctcggt tcactgcaac   2040

cttggcctcc taggttcaag caattctcct gccccagcct cctgagtagc tgggattaca   2100

ggtgtgtgcc accacacccg gccaattttt gtatctttag tagagatggg gttttgccat   2160

gttggccaga ctggtctcga actcctgacc tcaagtgatc cactggcctt ggcctcccaa   2220

agtgctggga ttacaggcat gagccacctc acttggccca attttaactt aattatctct   2280

gtcaagagcc tatctccata tacagtcaca tcctgagcta ctagggggta ggacttcaac   2340

atgcacttct gcaggggccg cagttcagcc aacatcatct ttttttttga gatggagtct   2400

cgctttgttg cccaggctgg agtgcggtgg tgcaatctcg gctcaccaca acctccacct   2460

cccaggttca agtgattctc ctgcctcagc ctcccgagtt gctgggacta taggtgtgcg   2520

ccaccatgcc cagctaattt tgtattttta gtagagacag gctttcgctg tgttggccag   2580

gctggtcttg aatgcctgac cttgccgccc gcctcggcct cccaaaatgc tgggattaca   2640

ggcgtgagcc accgcgcctg gcctcagcca acatcatcta agggctctca cggagggcct   2700

cccagctgcc cgccctgtgg gcatttgcac atatcctgac aagcctgaaa gaagctccgg   2760

gtgcccattg ttcagtccag gtgcccattg ttcccgggac tgaggcccgg gaaagggaag   2820

cgacgtgata gggccagcag cagaccctgg gcctttctct agactgagca ccattccccg   2880

tgggtgtgct ctcagcgccg caccgacctt cacactgcag agatggatgc caactccctg   2940

gcaggggcag gactgctgcc gagcagcccc acctgccctc ccagccacac cccaagtctg   3000

taagggccgc tcccaggaac acctgctact gcacactcca aaccaataaa gttttatatt   3060

ttgtttactt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa           3172


<210>  46
<211>  304
<212>  PRT
<213>  Homosapiens

<400>  46

Met Glu Thr Val Pro Pro Ala Val Asp Leu Val Leu Gly Ala Ser Ala 
1               5                   10                  15      


Cys Cys Leu Ala Cys Val Phe Thr Asn Pro Leu Glu Val Val Lys Thr 
            20                  25                  30          


Arg Leu Gln Leu Gln Gly Glu Leu Gln Ala Arg Gly Thr Tyr Pro Arg 
        35                  40                  45              


Pro Tyr His Gly Phe Ile Ala Ser Val Ala Ala Val Ala Arg Ala Asp 
    50                  55                  60                  


Gly Leu Trp Gly Leu Gln Lys Gly Leu Ala Ala Gly Leu Leu Tyr Gln 
65                  70                  75                  80  


Gly Leu Met Asn Gly Val Arg Phe Tyr Cys Tyr Ser Leu Ala Cys Gln 
                85                  90                  95      


Ala Gly Leu Thr Gln Gln Pro Gly Gly Thr Val Val Ala Gly Ala Val 
            100                 105                 110         


Ala Gly Ala Leu Gly Ala Phe Val Gly Ser Pro Ala Tyr Leu Ile Lys 
        115                 120                 125             


Thr Gln Leu Gln Ala Gln Thr Val Ala Ala Val Ala Val Gly His Gln 
    130                 135                 140                 


His Asn His Gln Thr Val Leu Gly Ala Leu Glu Thr Ile Trp Arg Gln 
145                 150                 155                 160 


Gln Gly Leu Leu Gly Leu Trp Gln Gly Val Gly Gly Ala Val Pro Arg 
                165                 170                 175     


Val Met Val Gly Ser Ala Ala Gln Leu Ala Thr Phe Ala Ser Ala Lys 
            180                 185                 190         


Ala Trp Val Gln Lys Gln Gln Trp Leu Pro Glu Asp Ser Trp Leu Val 
        195                 200                 205             


Ala Leu Ala Gly Gly Met Ile Ser Ser Ile Ala Val Val Val Val Met 
    210                 215                 220                 


Thr Pro Phe Asp Val Val Ser Thr Arg Leu Tyr Asn Gln Pro Val Asp 
225                 230                 235                 240 


Thr Ala Gly Arg Gly Gln Leu Tyr Gly Gly Leu Thr Asp Cys Met Val 
                245                 250                 255     


Lys Ile Trp Arg Gln Glu Gly Pro Leu Ala Leu Tyr Lys Gly Leu Gly 
            260                 265                 270         


Pro Ala Tyr Leu Arg Leu Gly Pro His Thr Ile Leu Ser Met Leu Phe 
        275                 280                 285             


Trp Asp Glu Leu Arg Lys Leu Ala Gly Arg Ala Gln His Lys Gly Thr 
    290                 295                 300                 


<210>  47
<211>  1520
<212>  DNA
<213>  Homosapiens

<400>  47
gctctcctcc cctcccctcc cctgggcctt tgacccctcc cagcctctct ccttccctcc     60

accgacacct ttgcccagtg acgttggtct gtccttacgc agacctggcc ggaggctggg    120

gctccttccg gggctgccat gttctctctt ccatccctcc cctcctggct ccccggcctc    180

ccctccctcg agtggggctc tagcctcctt gactccctcc tgcaaggcct gatcggggcc    240

cttggagtct tggtcctgaa cagcctcctg aaagtttact tcttcgtggg ctgtgccaat    300

gacccgcagc ggcgacccga aaaggagcgg cttcgggccc agtgggcctc cctggaaacg    360

gtgcacctgg cagggctggc cctgtttctg acggtcgtgg ggtcccgggt ggctgccctc    420

gtggtgctcg agttctccct ccgggccgtg tccacgctgc tgtccctggg caagggctcc    480

cagggtgccg ccgagaggct gcagctctac ctgctgtgcc agtactcgct gggctgcggg    540

ctgacctgtg gcctgagctt cctgcaggag ggcgcccctc accgcacgct gaacctgctg    600

ctgagcctcg ggctggccac gctgctgggc ctgggtgccc ggcgcctcca ccgccacgtc    660

tgccgcctct acgagctgca cagcagccag cgctactgtg gggtgtgcct gggcctgctg    720

gcccatgcac atggcctccc ccagctgctg ggccgtgccc tggccatagc ctttgccgtg    780

ggtgacctgg cagctgtggc cctcatcaac caggacttcc tgaccacctc ggaggccatg    840

cggttctgga caccgctcac catctgctac acgctgctgg tcatctacat gcaggaggag    900

cagcggcagc accccggcct gcagagccag gtgcagacgg tgctggtgcg catgggcggc    960

ctcttcgtgc tgctgctgac tgtgggtcgc tggctggacc tgctgggcat ccttgtctcc   1020

ctactgggcg agctctggtg tctcgtgggc gtccgcaccc tgcttgacct ctgccagata   1080

caggattttc catcccagag gcctccagtg tcaacaccaa gccagcccct gccctcggca   1140

ccccagtccc agagttcggc cccctcttga cctgcctcag ggaggatctg gagtctgtct   1200

caagcccact agcctgatct ccgaggcctt gaccccaggg cgatgcctgg aggcagagtg   1260

gcagagctgg cctcctgccc agagctcagc acaggccctg ggagccccga gaagggaagg   1320

caggatttgg ggatgggagc ctctggagag gggacacctg gggacccctg gttgaaccct   1380

ctttttcttg gggtgggcaa tgatgcagcc tctcagacct gccttcctgg gcaggggtgg   1440

gggtgcatcc tcaggagggc tcccccttta ctggtctccc ttcccttctc catgaacaat   1500

aaagacgatg tctttctcaa                                               1520


<210>  48
<211>  343
<212>  PRT
<213>  Homosapiens

<400>  48

Met Phe Ser Leu Pro Ser Leu Pro Ser Trp Leu Pro Gly Leu Pro Ser 
1               5                   10                  15      


Leu Glu Trp Gly Ser Ser Leu Leu Asp Ser Leu Leu Gln Gly Leu Ile 
            20                  25                  30          


Gly Ala Leu Gly Val Leu Val Leu Asn Ser Leu Leu Lys Val Tyr Phe 
        35                  40                  45              


Phe Val Gly Cys Ala Asn Asp Pro Gln Arg Arg Pro Glu Lys Glu Arg 
    50                  55                  60                  


Leu Arg Ala Gln Trp Ala Ser Leu Glu Thr Val His Leu Ala Gly Leu 
65                  70                  75                  80  


Ala Leu Phe Leu Thr Val Val Gly Ser Arg Val Ala Ala Leu Val Val 
                85                  90                  95      


Leu Glu Phe Ser Leu Arg Ala Val Ser Thr Leu Leu Ser Leu Gly Lys 
            100                 105                 110         


Gly Ser Gln Gly Ala Ala Glu Arg Leu Gln Leu Tyr Leu Leu Cys Gln 
        115                 120                 125             


Tyr Ser Leu Gly Cys Gly Leu Thr Cys Gly Leu Ser Phe Leu Gln Glu 
    130                 135                 140                 


Gly Ala Pro His Arg Thr Leu Asn Leu Leu Leu Ser Leu Gly Leu Ala 
145                 150                 155                 160 


Thr Leu Leu Gly Leu Gly Ala Arg Arg Leu His Arg His Val Cys Arg 
                165                 170                 175     


Leu Tyr Glu Leu His Ser Ser Gln Arg Tyr Cys Gly Val Cys Leu Gly 
            180                 185                 190         


Leu Leu Ala His Ala His Gly Leu Pro Gln Leu Leu Gly Arg Ala Leu 
        195                 200                 205             


Ala Ile Ala Phe Ala Val Gly Asp Leu Ala Ala Val Ala Leu Ile Asn 
    210                 215                 220                 


Gln Asp Phe Leu Thr Thr Ser Glu Ala Met Arg Phe Trp Thr Pro Leu 
225                 230                 235                 240 


Thr Ile Cys Tyr Thr Leu Leu Val Ile Tyr Met Gln Glu Glu Gln Arg 
                245                 250                 255     


Gln His Pro Gly Leu Gln Ser Gln Val Gln Thr Val Leu Val Arg Met 
            260                 265                 270         


Gly Gly Leu Phe Val Leu Leu Leu Thr Val Gly Arg Trp Leu Asp Leu 
        275                 280                 285             


Leu Gly Ile Leu Val Ser Leu Leu Gly Glu Leu Trp Cys Leu Val Gly 
    290                 295                 300                 


Val Arg Thr Leu Leu Asp Leu Cys Gln Ile Gln Asp Phe Pro Ser Gln 
305                 310                 315                 320 


Arg Pro Pro Val Ser Thr Pro Ser Gln Pro Leu Pro Ser Ala Pro Gln 
                325                 330                 335     


Ser Gln Ser Ser Ala Pro Ser 
            340             


<210>  49
<211>  1521
<212>  DNA
<213>  Homosapiens

<400>  49
tggcctgaac ctccaggact tcagcccttc taggagaatc tgatcccagg tgagggaggt     60

cacttggggt gtggcccagc aggcaggcgg gactccagac tgggaacgga agtcagccct    120

gctggggctg ggagctgaag catctgttcc ttcctcgcgg gtgtgagaca aggaagagtg    180

atcattgcca caccaggagc tgaagccatg gcctcaaagc ctgagaagag ggtggcatcg    240

tctgtcttta tcaccctggc acccccgcgc cgcgatgtgg ccgtggcgga ggaagtgagg    300

caggcagttt gtgaggcccg gcgtggccgc ccctgggagg ctcctgcccc catgaagaca    360

cccgaggctg gcttggcggg gaggcccagc ccctggacaa cccctggcag agctgcagcc    420

acagtgccgg ctgcacctat gcagctcttc aatggaggat gcccaccccc tcctcctgtc    480

ctggatggtg aggacgtgct tcctgacctg gacctcctcc caccccctcc accgccccct    540

ccagtgcttc tgccttctga agaggaggct cctgctccaa tgggggcctc actcattgca    600

gacttagagc agctgcacct gtccccgccc ccgcccccac cacaggcccc agcggaggga    660

ccttcagtcc agcccggtcc cctcaggccc atggaggaag agctgccacc tcccccggca    720

gaacctgttg agaaaggggc atccacagac atctgtgcct tctgccacaa gaccgtgtcc    780

ccccgagagc tggctgtgga ggccatgaag aggcagtacc atgcccagtg cttcacgtgc    840

cgcacctgcc gccgccagct ggctgggcag agcttctacc agaaggatgg gcgacccctc    900

tgcgaaccct gctaccagga cacactggag aggtgcggca agtgtggcga ggtggtccgg    960

gaccacatca tcagggccct gggccaggcc ttccacccct cctgcttcac gtgtgtgacc   1020

tgcgcccggt gcattgggga tgagagcttt gccctgggca gccagaacga ggtgtactgc   1080

ctggacgact tctacaggta cgagaagggt ttgtgcactg ggtggggtgc agggacaggg   1140

cgagacccaa gcagggtgaa ggagctgagc ttgagtcctg ggtgctgggc cagagtttcc   1200

tgtctactgg tttattataa agaatattac agggctgggc tgggcgcggt ggctcacgcc   1260

tgtaatccca gcactttggg aggccgaggc gggtggatca cgaggtcagg agatcgagat   1320

catcctggct aacatggtga aaccccgtct ctactaaaaa tacaaaaaaa attagccagg   1380

catggtggcg ggcgcctgta gtcccagcta ctcgggaggc tgaggcagga gaatggcgtg   1440

aacctgggag gcagagcttg cagtgagccg agatcacgcc actgcactcc agcctgggca   1500

acagagtgtg agactccgtc t                                             1521


<210>  50
<211>  374
<212>  PRT
<213>  Homosapiens

<400>  50

Met Ala Ser Lys Pro Glu Lys Arg Val Ala Ser Ser Val Phe Ile Thr 
1               5                   10                  15      


Leu Ala Pro Pro Arg Arg Asp Val Ala Val Ala Glu Glu Val Arg Gln 
            20                  25                  30          


Ala Val Cys Glu Ala Arg Arg Gly Arg Pro Trp Glu Ala Pro Ala Pro 
        35                  40                  45              


Met Lys Thr Pro Glu Ala Gly Leu Ala Gly Arg Pro Ser Pro Trp Thr 
    50                  55                  60                  


Thr Pro Gly Arg Ala Ala Ala Thr Val Pro Ala Ala Pro Met Gln Leu 
65                  70                  75                  80  


Phe Asn Gly Gly Cys Pro Pro Pro Pro Pro Val Leu Asp Gly Glu Asp 
                85                  90                  95      


Val Leu Pro Asp Leu Asp Leu Leu Pro Pro Pro Pro Pro Pro Pro Pro 
            100                 105                 110         


Val Leu Leu Pro Ser Glu Glu Glu Ala Pro Ala Pro Met Gly Ala Ser 
        115                 120                 125             


Leu Ile Ala Asp Leu Glu Gln Leu His Leu Ser Pro Pro Pro Pro Pro 
    130                 135                 140                 


Pro Gln Ala Pro Ala Glu Gly Pro Ser Val Gln Pro Gly Pro Leu Arg 
145                 150                 155                 160 


Pro Met Glu Glu Glu Leu Pro Pro Pro Pro Ala Glu Pro Val Glu Lys 
                165                 170                 175     


Gly Ala Ser Thr Asp Ile Cys Ala Phe Cys His Lys Thr Val Ser Pro 
            180                 185                 190         


Arg Glu Leu Ala Val Glu Ala Met Lys Arg Gln Tyr His Ala Gln Cys 
        195                 200                 205             


Phe Thr Cys Arg Thr Cys Arg Arg Gln Leu Ala Gly Gln Ser Phe Tyr 
    210                 215                 220                 


Gln Lys Asp Gly Arg Pro Leu Cys Glu Pro Cys Tyr Gln Asp Thr Leu 
225                 230                 235                 240 


Glu Arg Cys Gly Lys Cys Gly Glu Val Val Arg Asp His Ile Ile Arg 
                245                 250                 255     


Ala Leu Gly Gln Ala Phe His Pro Ser Cys Phe Thr Cys Val Thr Cys 
            260                 265                 270         


Ala Arg Cys Ile Gly Asp Glu Ser Phe Ala Leu Gly Ser Gln Asn Glu 
        275                 280                 285             


Val Tyr Cys Leu Asp Asp Phe Tyr Arg Tyr Glu Lys Gly Leu Cys Thr 
    290                 295                 300                 


Gly Trp Gly Ala Gly Thr Gly Arg Asp Pro Ser Arg Val Lys Glu Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Cys Trp Ala Arg Val Ser Cys Leu Leu Val Tyr 
                325                 330                 335     


Tyr Lys Glu Tyr Tyr Arg Ala Gly Leu Gly Ala Val Ala His Ala Cys 
            340                 345                 350         


Asn Pro Ser Thr Leu Gly Gly Arg Gly Gly Trp Ile Thr Arg Ser Gly 
        355                 360                 365             


Asp Arg Asp His Pro Gly 
    370                 


<210>  51
<211>  2793
<212>  DNA
<213>  Homosapiens

<400>  51
ccacaccagg agctgaagcc atggcctcaa agcctgagaa gagggtggca tcgtctgtct     60

ttatcaccct ggcacccccg cgccgcgatg tggccgtggc ggaggaagtg aggcaggcag    120

tttgtgaggc ccggcgtggc cgcccctggg aggctcctgc ccccatgaag acacccgagg    180

ctggcttggc ggggaggccc agcccctgga caacccctgg cagagctgca gccacagtgc    240

cggctgcacc tatgcagctc ttcaatggag acatctgtgc cttctgccac aagaccgtgt    300

ccccccgaga gctggctgtg gaggccatga agaggcagta ccatgcccag tgcttcacgt    360

gccgcacctg ccgccgccag ctggctgggc agagcttcta ccagaaggat gggcgacccc    420

tctgcgaacc ctgctaccag gacacactgg agaggtgcgg caagtgtggc gaggtggtcc    480

gggaccacat catcagggcc ctgggccagg ccttccaccc ctcctgcttc acgtgtgtga    540

cctgcgcccg gtgcattggg gatgagagct ttgccctggg cagccagaac gaggtgtact    600

gcctggacga cttctacagg aaattcgccc ccgtctgcag catctgtgaa aatcccatca    660

tccctcggga tgggaaagat gccttcaaaa tcgaatgcat gggaagaaac ttccatgaaa    720

attgctacag gtgtgaggac tgcaggatcc tcctgtctgt cgagcccacg gaccaaggct    780

gctaccccct gaacaaccat ctcttctgca agccatgcca tgtgaagcgg agtgctgcgg    840

ggtgctgctg agagtgcccg ctgggcagtg aacagaccac tagccccggc tggggccctt    900

ccctgacttg gtttcccttc ctaacctgct cttgcacact ttccttctga gcctccatgg    960

agaccagcct gcaagccggc ccagcctgtc caggatacag tggggctgag cacccccagg   1020

ccttccactc ctctaccctc tgggcaccag aaggctcctg gaccatgagc ttcaccccca   1080

gaattccctg ctgaccctgc cccacttcca gggaaaagct gggggaggtt ggacccctct   1140

cactgactag ctgtctggta ggggtgctag gaccagcctc gcctgtgggg ttgagctgtt   1200

tgaggacaaa ctccaaggtc ccttaaaaag tgccttttag aggctgggca tggtggctca   1260

cgcttgtaat cccagcactt tgggaggcca aggtgggtgg atcacctgag gtcaggagtt   1320

caagaccagc ctggccaaca tggtgaaacc ctgtctctac taaaaataca aaaattagcc   1380

aggcatggta gcaggtgcct gtaatcccag ctactgggga aagctgaggc aggagaattg   1440

cttcaatctg gaaggcagag gttgcagtga gattgcacca ttgcattcca gcctgggcaa   1500

caagagggaa actccgtctc aaaaaaaaaa aagtgccttt taggccggat gtggtggctc   1560

atgcctgtaa tcccagcact ttgggaggcc aaggcaggca gatcacttga ggtcaggagt   1620

ttgagaccag cctggccaac acggcaaaac cccgtttcta ctaaaaatac aaaaattagc   1680

tgggtgtggt ggcgtgcgcc tgtaatccca gctactcagg aggctgaggc aggagcattg   1740

cttgaacccg ggaggcagag gttgcagtga gctgagatgg caccactgca ctccagcctg   1800

ggagacacag cgagactctg tctccaaaaa aaaaagtgct ttttgaaaat gttgaggttg   1860

aaatgatggg aaccaacatt ctttggattt agtggggagc ataatagcaa acaccccctt   1920

ggttcgcaca tgtacaggaa tgggacccag ttggggcaca gccatggact tccccgccct   1980

ggaatgtgtg gtgcaaagtg gggccagggc ccagacccaa gaggagaggg tggtccgcag   2040

acaccccggg atgtcagcat cccccgacct gccttctggc ggcacctccc gggtgctgtg   2100

ttgagtcagc aggcatgggg tgagagcctg gtatatgctg ggaacagggt gcaggggcca   2160

agcgttcctc cttcagcctt gacttgggcc atgcaccccc tctcccccaa acacaaacaa   2220

gcacttctcc agtatggtgc caggacaggt gtcccttcag tcctctggtt atgacctcaa   2280

gtcctacttg ggccctgcag cccagcctgt gttgtaacct ctgcgtcctc aagaccacac   2340

ctggaagatt cttcttccct ttgaaggaga atcatcattg ttgctttatc acttctaaga   2400

cattttgtac ggcacggaca agttaaacag aatgtgcttc cctccctggg gtctcacacg   2460

ctcccacgag aatgccacag gggccgtgca ctgggcaggc ttctctgtag aaccccaggg   2520

gcttcggccc agaccacagc gtcttgccct gagcctagag cagggagtcc cgaacttctg   2580

cattcacaga ccacctccac aattgttata accaaaggcc tcctgttctg ttatttcact   2640

taaatcaaca tgctattttg ttttcactca cttctgactt tagcctcgtg ctgagccgtg   2700

tatccatgca gtcatgttca cgtgctagtt acgtttttct tcttacacat gaaaataaat   2760

gcataagtgt tagaagctca aaaaaaaaaa aaa                                2793


<210>  52
<211>  276
<212>  PRT
<213>  Homosapiens

<400>  52

Met Ala Ser Lys Pro Glu Lys Arg Val Ala Ser Ser Val Phe Ile Thr 
1               5                   10                  15      


Leu Ala Pro Pro Arg Arg Asp Val Ala Val Ala Glu Glu Val Arg Gln 
            20                  25                  30          


Ala Val Cys Glu Ala Arg Arg Gly Arg Pro Trp Glu Ala Pro Ala Pro 
        35                  40                  45              


Met Lys Thr Pro Glu Ala Gly Leu Ala Gly Arg Pro Ser Pro Trp Thr 
    50                  55                  60                  


Thr Pro Gly Arg Ala Ala Ala Thr Val Pro Ala Ala Pro Met Gln Leu 
65                  70                  75                  80  


Phe Asn Gly Asp Ile Cys Ala Phe Cys His Lys Thr Val Ser Pro Arg 
                85                  90                  95      


Glu Leu Ala Val Glu Ala Met Lys Arg Gln Tyr His Ala Gln Cys Phe 
            100                 105                 110         


Thr Cys Arg Thr Cys Arg Arg Gln Leu Ala Gly Gln Ser Phe Tyr Gln 
        115                 120                 125             


Lys Asp Gly Arg Pro Leu Cys Glu Pro Cys Tyr Gln Asp Thr Leu Glu 
    130                 135                 140                 


Arg Cys Gly Lys Cys Gly Glu Val Val Arg Asp His Ile Ile Arg Ala 
145                 150                 155                 160 


Leu Gly Gln Ala Phe His Pro Ser Cys Phe Thr Cys Val Thr Cys Ala 
                165                 170                 175     


Arg Cys Ile Gly Asp Glu Ser Phe Ala Leu Gly Ser Gln Asn Glu Val 
            180                 185                 190         


Tyr Cys Leu Asp Asp Phe Tyr Arg Lys Phe Ala Pro Val Cys Ser Ile 
        195                 200                 205             


Cys Glu Asn Pro Ile Ile Pro Arg Asp Gly Lys Asp Ala Phe Lys Ile 
    210                 215                 220                 


Glu Cys Met Gly Arg Asn Phe His Glu Asn Cys Tyr Arg Cys Glu Asp 
225                 230                 235                 240 


Cys Arg Ile Leu Leu Ser Val Glu Pro Thr Asp Gln Gly Cys Tyr Pro 
                245                 250                 255     


Leu Asn Asn His Leu Phe Cys Lys Pro Cys His Val Lys Arg Ser Ala 
            260                 265                 270         


Ala Gly Cys Cys 
        275     


<210>  53
<211>  3363
<212>  DNA
<213>  Homosapiens

<400>  53
ggacgggcgg aggggacggg aggcccagcg gctccgggct ccgctggctc gggcgtcgga     60

tcggagccgc cggggcgcgg gcggcccaga gctggcctga acctccagga cttcagccct    120

tctaggagaa tctgatccca ggtgagggag gtcacttggg gtgtggccca gcaggcaggc    180

gggactccag actgggaacg gaagtcagcc ctgctggggc tgggagctga agcatctgtt    240

ccttcctcgc gggtgtgaga caaggaagag tgatcattgc cacaccagga gctgaagcca    300

tggcctcaaa gcctgagaag agggtggcat cgtctgtctt tatcaccctg gcacccccgc    360

gccgcgatgt ggccgtggcg gaggaagtga ggcaggcagt ttgtgaggcc cggcgtggcc    420

gcccctggga ggctcctgcc cccatgaaga cacccgaggc tggcttggcg gggaggccca    480

gcccctggac aacccctggc agagctgcag ccacagtgcc ggctgcacct atgcagctct    540

tcaatggagg atgcccaccc cctcctcctg tcctggatgg tgaggacgtg cttcctgacc    600

tggacctcct cccaccccct ccaccgcccc ctccagtgct tctgccttct gaagaggagg    660

ctcctgctcc aatgggggcc tcactcattg cagacttaga gcagctgcac ctgtccccgc    720

ccccgccccc accacaggcc ccagcggagg gaccttcagt ccagcccggt cccctcaggc    780

ccatggagga agagctgcca cctcccccgg cagaacctgt tgagaaaggg gcatccacag    840

acatctgtgc cttctgccac aagaccgtgt ccccccgaga gctggctgtg gaggccatga    900

agaggcagta ccatgcccag tgcttcacgt gccgcacctg ccgccgccag ctggctgggc    960

agagcttcta ccagaaggat gggcgacccc tctgcgaacc ctgctaccag gacacactgg   1020

agaggtgcgg caagtgtggc gaggtggtcc gggaccacat catcagggcc ctgggccagg   1080

ccttccaccc ctcctgcttc acgtgtgtga cctgcgcccg gtgcattggg gatgagagct   1140

ttgccctggg cagccagaac gaggtgtact gcctggacga cttctacagg aaattcgccc   1200

ccgtctgcag catctgtgaa aatcccatca tccctcggga tgggaaagat gccttcaaaa   1260

tcgaatgcat gggaagaaac ttccatgaaa attgctacag gtgtgaggac tgcaggatcc   1320

tcctgtctgt cgagcccacg gaccaaggct gctaccccct gaacaaccat ctcttctgca   1380

agccatgcca tgtgaagcgg agtgctgcgg ggtgctgctg agagtgcccg ctgggcagtg   1440

aacagaccac tagccccggc tggggccctt ccctgacttg gtttcccttc ctaacctgct   1500

cttgcacact ttccttctga gcctccatgg agaccagcct gcaagccggc ccagcctgtc   1560

caggatacag tggggctgag cacccccagg ccttccactc ctctaccctc tgggcaccag   1620

aaggctcctg gaccatgagc ttcaccccca gaattccctg ctgaccctgc cccacttcca   1680

gggaaaagct gggggaggtt ggacccctct cactgactag ctgtctggta ggggtgctag   1740

gaccagcctc gcctgtgggg ttgagctgtt tgaggacaaa ctccaaggtc ccttaaaaag   1800

tgccttttag aggctgggca tggtggctca cgcttgtaat cccagcactt tgggaggcca   1860

aggtgggtgg atcacctgag gtcaggagtt caagaccagc ctggccaaca tggtgaaacc   1920

ctgtctctac taaaaataca aaaattagcc aggcatggta gcaggtgcct gtaatcccag   1980

ctactgggga aagctgaggc aggagaattg cttcaatctg gaaggcagag gttgcagtga   2040

gattgcacca ttgcattcca gcctgggcaa caagagggaa actccgtctc aaaaaaaaaa   2100

aagtgccttt taggccggat gtggtggctc atgcctgtaa tcccagcact ttgggaggcc   2160

aaggcaggca gatcacttga ggtcaggagt ttgagaccag cctggccaac acggcaaaac   2220

cccgtttcta ctaaaaatac aaaaattagc tgggtgtggt ggcgtgcgcc tgtaatccca   2280

gctactcagg aggctgaggc aggagcattg cttgaacccg ggaggcagag gttgcagtga   2340

gctgagatgg caccactgca ctccagcctg ggagacacag cgagactctg tctccaaaaa   2400

aaaaagtgct ttttgaaaat gttgaggttg aaatgatggg aaccaacatt ctttggattt   2460

agtggggagc ataatagcaa acaccccctt ggttcgcaca tgtacaggaa tgggacccag   2520

ttggggcaca gccatggact tccccgccct ggaatgtgtg gtgcaaagtg gggccagggc   2580

ccagacccaa gaggagaggg tggtccgcag acaccccggg atgtcagcat cccccgacct   2640

gccttctggc ggcacctccc gggtgctgtg ttgagtcagc aggcatgggg tgagagcctg   2700

gtatatgctg ggaacagggt gcaggggcca agcgttcctc cttcagcctt gacttgggcc   2760

atgcaccccc tctcccccaa acacaaacaa gcacttctcc agtatggtgc caggacaggt   2820

gtcccttcag tcctctggtt atgacctcaa gtcctacttg ggccctgcag cccagcctgt   2880

gttgtaacct ctgcgtcctc aagaccacac ctggaagatt cttcttccct ttgaaggaga   2940

atcatcattg ttgctttatc acttctaaga cattttgtac ggcacggaca agttaaacag   3000

aatgtgcttc cctccctggg gtctcacacg ctcccacgag aatgccacag gggccgtgca   3060

ctgggcaggc ttctctgtag aaccccaggg gcttcggccc agaccacagc gtcttgccct   3120

gagcctagag cagggagtcc cgaacttctg cattcacaga ccacctccac aattgttata   3180

accaaaggcc tcctgttctg ttatttcact taaatcaaca tgctattttg ttttcactca   3240

cttctgactt tagcctcgtg ctgagccgtg tatccatgca gtcatgttca cgtgctagtt   3300

acgtttttct tcttacacat gaaaataaat gcataagtgt tagaagctca aaaaaaaaaa   3360

aaa                                                                 3363


<210>  54
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  54

Met Ala Ser Lys Pro Glu Lys Arg Val Ala Ser Ser Val Phe Ile Thr 
1               5                   10                  15      


Leu Ala Pro Pro Arg Arg Asp Val Ala Val Ala Glu Glu Val Arg Gln 
            20                  25                  30          


Ala Val Cys Glu Ala Arg Arg Gly Arg Pro Trp Glu Ala Pro Ala Pro 
        35                  40                  45              


Met Lys Thr Pro Glu Ala Gly Leu Ala Gly Arg Pro Ser Pro Trp Thr 
    50                  55                  60                  


Thr Pro Gly Arg Ala Ala Ala Thr Val Pro Ala Ala Pro Met Gln Leu 
65                  70                  75                  80  


Phe Asn Gly Gly Cys Pro Pro Pro Pro Pro Val Leu Asp Gly Glu Asp 
                85                  90                  95      


Val Leu Pro Asp Leu Asp Leu Leu Pro Pro Pro Pro Pro Pro Pro Pro 
            100                 105                 110         


Val Leu Leu Pro Ser Glu Glu Glu Ala Pro Ala Pro Met Gly Ala Ser 
        115                 120                 125             


Leu Ile Ala Asp Leu Glu Gln Leu His Leu Ser Pro Pro Pro Pro Pro 
    130                 135                 140                 


Pro Gln Ala Pro Ala Glu Gly Pro Ser Val Gln Pro Gly Pro Leu Arg 
145                 150                 155                 160 


Pro Met Glu Glu Glu Leu Pro Pro Pro Pro Ala Glu Pro Val Glu Lys 
                165                 170                 175     


Gly Ala Ser Thr Asp Ile Cys Ala Phe Cys His Lys Thr Val Ser Pro 
            180                 185                 190         


Arg Glu Leu Ala Val Glu Ala Met Lys Arg Gln Tyr His Ala Gln Cys 
        195                 200                 205             


Phe Thr Cys Arg Thr Cys Arg Arg Gln Leu Ala Gly Gln Ser Phe Tyr 
    210                 215                 220                 


Gln Lys Asp Gly Arg Pro Leu Cys Glu Pro Cys Tyr Gln Asp Thr Leu 
225                 230                 235                 240 


Glu Arg Cys Gly Lys Cys Gly Glu Val Val Arg Asp His Ile Ile Arg 
                245                 250                 255     


Ala Leu Gly Gln Ala Phe His Pro Ser Cys Phe Thr Cys Val Thr Cys 
            260                 265                 270         


Ala Arg Cys Ile Gly Asp Glu Ser Phe Ala Leu Gly Ser Gln Asn Glu 
        275                 280                 285             


Val Tyr Cys Leu Asp Asp Phe Tyr Arg Lys Phe Ala Pro Val Cys Ser 
    290                 295                 300                 


Ile Cys Glu Asn Pro Ile Ile Pro Arg Asp Gly Lys Asp Ala Phe Lys 
305                 310                 315                 320 


Ile Glu Cys Met Gly Arg Asn Phe His Glu Asn Cys Tyr Arg Cys Glu 
                325                 330                 335     


Asp Cys Arg Ile Leu Leu Ser Val Glu Pro Thr Asp Gln Gly Cys Tyr 
            340                 345                 350         


Pro Leu Asn Asn His Leu Phe Cys Lys Pro Cys His Val Lys Arg Ser 
        355                 360                 365             


Ala Ala Gly Cys Cys 
    370             


<210>  55
<211>  533
<212>  DNA
<213>  Homosapiens

<400>  55
tgtaggtgcc gctgttgctg ctcgtgttaa atctagaacc gtagccagac atgggactgg     60

aggacgagca aaagatgctt accgaatccg gagatcctga ggaggaggaa gaggaagagg    120

aggaattagt ggatccccta acaacagtga gagagcaatg cgagcagttg gagaaatgtg    180

taaaggcccg ggagcggcta gagctctatg atgagcatgt atcctctcga tcacatacag    240

aagaggattg cacggaggag ctctttgact tcttgcatgc aaaggaccat tgcgtggccc    300

acaaactctt taacaacttg aaataaatgt gtggacttaa ttcaccccag ccttcatcat    360

ctgggcatca gaatatttcc ttatggtttc ggatgtacca tttgtttctt atttgtgtaa    420

ctgtaagttc acatgaacct cgtgggtttt ggcttaggct ggtagcttct atgtaattcg    480

cagtgattcc atctaaataa aagttctgtg atctgcaaaa aaaaaaaaaa att           533


<210>  56
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  56

Met Gly Leu Glu Asp Glu Gln Lys Met Leu Thr Glu Ser Gly Asp Pro 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Leu Val Asp Pro Leu Thr Thr 
            20                  25                  30          


Val Arg Glu Gln Cys Glu Gln Leu Glu Lys Cys Val Lys Ala Arg Glu 
        35                  40                  45              


Arg Leu Glu Leu Tyr Asp Glu His Val Ser Ser Arg Ser His Thr Glu 
    50                  55                  60                  


Glu Asp Cys Thr Glu Glu Leu Phe Asp Phe Leu His Ala Lys Asp His 
65                  70                  75                  80  


Cys Val Ala His Lys Leu Phe Asn Asn Leu Lys 
                85                  90      


<210>  57
<211>  2176
<212>  DNA
<213>  Homosapiens

<400>  57
ctctgtctca aaaacaaaac aaaacaaaaa cagaaagaat cagagtcaac aaatcagtat     60

ggatgcagat tcctcagatg ccaggaatcc caggataaat ggcaggggtg aaccaaatac    120

ttcccattct tccctcacca ccctcctcca tccaataaag aagtaaataa attcctcaag    180

tcccctctgc cccagtgcat ggaatgttta cctgtggact aggactggtc tacatgccaa    240

acaggccttg cctcctgggc ggcatgtttg caggggatcc ttgctgatga tgttggcctc    300

ctcctgcacc ctcccactcc atggctgtct cacctgagag agctttcttc cttttgcatt    360

aagtgtgagt cctgataaat tcaaaaaagc ctccaggtga catcatttta acaccagtta    420

acaatcacaa atctgggtga atgagcctca gagtttttct tgacagtagt gtgcgtgcgt    480

gtgtgtgtgc gtgttttcca tggaaaaata aaatgtatta cacaaactat cagtattaat    540

tacagaaagg tggccaggtg cagtgcctca cgcctgtaat cctggcactt tgggaggcca    600

aggcgggcag attgcctgag ctcaggagtt tgagaccagc ctggtcaaac atggtgaaac    660

cctgtatcta ctaaaaatac aaaacattag ctgggcgtgg tggcgcatgc ctgtagtctc    720

aggtactcgg aagggtgagg cacaagaatc gcttgagtct ggaaggtgga ggttgcagtg    780

agccgagaac acgccactaa actccagccg gggtgacaga gcaagactct gtctcaaaaa    840

acaaacaaac aattaattac agaaaggtaa gcctggccaa taggtcagga aaagcagccc    900

cactgcagat ccacaccact acggaaactt gaggcaccac acacatgact ttgctgactg    960

ggggcaaagg atgaactagt gagcaaactt gggaggctga gacaggagga tcgcttgaac   1020

ctgggaggta gaggttgcag tgagccaaga tcgcaccact gctctccagc caggtgacag   1080

agcgagactc cagctcaaaa aaaaaaaaaa agtcaagata ttaaatatga aagcaacact   1140

ttatttttta ttttatttta ttttaagaca gggtctctct ctgtcaccca gactggagta   1200

cagtgacatg atctctgctc actgtgatct ctgcctccca ggctcaaact atcctcccac   1260

atcagcctcc caaatagctg ggactacagg ggcccaccac cacacctgac taatttttgt   1320

atttttggta gagatgcggt ttcaccatgt tgcccagcct gatcttgaac ttctggattc   1380

aagtgatccg ccctcctcgg cctcccaaag tgctgggact acaggcttga gccacctcgc   1440

ccagctgaaa gtgacacttt aatactttca ggaaattata ggagatgatt gttaagagct   1500

caggataaag agaagtttct ggccgggaac ggtggctcac acctgtaatc ccagcacttt   1560

cagtggcgga gcacctgtgg ccaagagttt gagaccagcc tggccaacat ggtgaaaccc   1620

catctctact aaaaatacaa aaattgaggt gccgctgttg ctgctcgtgt taaatctaga   1680

accgtagcca gacatgggac tggaggacga gcaaaagatg cttaccgaat ccggagatcc   1740

tgaggaggag gaagaggaag aggaggaatt agtggatccc ctaacaacag tgagagagca   1800

atgcgagcag ttggagaaat gtgtaaaggc ccgggagcgg ctagagctct atgatgagca   1860

tgtatcctct cgatcacata cagaagagga ttgcacggag gagctctttg acttcttgca   1920

tgcaaaggac cattgcgtgg cccacaaact ctttaacaac ttgaaataaa tgtgtggact   1980

taattcaccc cagccttcat catctgggca tcagaatatt tccttatggt ttcggatgta   2040

ccatttgttt cttatttgtg taactgtaag ttcacatgaa cctcgtgggt tttggcttag   2100

gctggtagct tctatgtaat tcgcagtgat tccatctaaa taaaagttct gtgatctgca   2160

aaaaaaaaaa aaaatt                                                   2176


<210>  58
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  58

Met Gly Leu Glu Asp Glu Gln Lys Met Leu Thr Glu Ser Gly Asp Pro 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Leu Val Asp Pro Leu Thr Thr 
            20                  25                  30          


Val Arg Glu Gln Cys Glu Gln Leu Glu Lys Cys Val Lys Ala Arg Glu 
        35                  40                  45              


Arg Leu Glu Leu Tyr Asp Glu His Val Ser Ser Arg Ser His Thr Glu 
    50                  55                  60                  


Glu Asp Cys Thr Glu Glu Leu Phe Asp Phe Leu His Ala Lys Asp His 
65                  70                  75                  80  


Cys Val Ala His Lys Leu Phe Asn Asn Leu Lys 
                85                  90      


<210>  59
<211>  455
<212>  DNA
<213>  Homosapiens

<400>  59
ccacgcccgc agccatgccg accaagggcc cgctgcagtc ggtgcaggtc ttcggacgca     60

agaagacagc cacagctgtg gcgcactgca aacgcggcaa tggtctcatc aaggtgaacg    120

ggtggcccct ggagatgatt gagctgcgca tgctacaata caagctgctg gagccagttc    180

tgcttctcgg caaggagcgg tttgctggtg tggacatctg tgtccgtatg aagggtggtg    240

gtcacgtggc ccagatttat gctatccatc agtccatctc caaagccctg gtggcctact    300

accagaaata tgtggatgag gcttccaaga aggagatcaa agacatcctc atccagtatg    360

accagaccct gctggtagct gatcctcgtt gccgggagtc caaaaagttt ggaggccctg    420

gtgcccatgc tcgctaccag aaatcctacc gataa                               455


<210>  60
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  60

Met Pro Thr Lys Gly Pro Leu Gln Ser Val Gln Val Phe Gly Arg Lys 
1               5                   10                  15      


Lys Thr Ala Thr Ala Val Ala His Cys Lys Arg Gly Asn Gly Leu Ile 
            20                  25                  30          


Lys Val Asn Gly Trp Pro Leu Glu Met Ile Glu Leu Arg Met Leu Gln 
        35                  40                  45              


Tyr Lys Leu Leu Glu Pro Val Leu Leu Leu Gly Lys Glu Arg Phe Ala 
    50                  55                  60                  


Gly Val Asp Ile Cys Val Arg Met Lys Gly Gly Gly His Val Ala Gln 
65                  70                  75                  80  


Ile Tyr Ala Ile His Gln Ser Ile Ser Lys Ala Leu Val Ala Tyr Tyr 
                85                  90                  95      


Gln Lys Tyr Val Asp Glu Ala Ser Lys Lys Glu Ile Lys Asp Ile Leu 
            100                 105                 110         


Ile Gln Tyr Asp Gln Thr Leu Leu Val Ala Asp Pro Arg Cys Arg Glu 
        115                 120                 125             


Ser Lys Lys Phe Gly Gly Pro Gly Ala His Ala Arg Tyr Gln Lys Ser 
    130                 135                 140                 


Tyr Arg 
145     


<210>  61
<211>  465
<212>  DNA
<213>  Homosapiens

<400>  61
ccacgcccgc agccatgccg accaagggcc cgctgcagtc ggtgcaggtc ttcggacgca     60

agaagacagc cacagctgtg gcgcactgca aacgcggcaa tggtctcatc aagctgctgg    120

agccagttct gcttctcggc aaggagcggt ttgctggtgt ggacatctgt gtccgtatga    180

agggtggtgg tcacgtggcc cagatttatg ctatccatca gtccatctcc aaagccctgg    240

tggcctacta ccagaaatat gtggatgagg cttccaagaa ggagatcaaa gacatcctca    300

tccagtatga ccagaccctg ctggtagctg atcctcgttg ccgggagtcc aaaaagtttg    360

gaggccctgg tgcccatgct cgctaccaga aatcctaccg ataagcccat catgactatc    420

aaaattcacc tgtataataa acagtttttg agggatttta aagtt                    465


<210>  62
<211>  129
<212>  PRT
<213>  Homosapiens

<400>  62

Met Pro Thr Lys Gly Pro Leu Gln Ser Val Gln Val Phe Gly Arg Lys 
1               5                   10                  15      


Lys Thr Ala Thr Ala Val Ala His Cys Lys Arg Gly Asn Gly Leu Ile 
            20                  25                  30          


Lys Leu Leu Glu Pro Val Leu Leu Leu Gly Lys Glu Arg Phe Ala Gly 
        35                  40                  45              


Val Asp Ile Cys Val Arg Met Lys Gly Gly Gly His Val Ala Gln Ile 
    50                  55                  60                  


Tyr Ala Ile His Gln Ser Ile Ser Lys Ala Leu Val Ala Tyr Tyr Gln 
65                  70                  75                  80  


Lys Tyr Val Asp Glu Ala Ser Lys Lys Glu Ile Lys Asp Ile Leu Ile 
                85                  90                  95      


Gln Tyr Asp Gln Thr Leu Leu Val Ala Asp Pro Arg Cys Arg Glu Ser 
            100                 105                 110         


Lys Lys Phe Gly Gly Pro Gly Ala His Ala Arg Tyr Gln Lys Ser Tyr 
        115                 120                 125             


Arg 
    


<210>  63
<211>  1100
<212>  DNA
<213>  Homosapiens

<400>  63
ggcctcccac ttggttgctc gtacgcggct agtgggtcct cagtggatgt aggctgggcg     60

ccgcgatgtt cgacgggaca ccggcggaga gcgacctcgg ggttaagggg tggggctgga    120

cgtcaggagc caagatggcg gcggtggtcg cactctcctt gaggcgccgg ttgccggcca    180

caacccttgg cggagcctgc ctgcaggcct cccgaggagc ccagacagct gcagccacag    240

ctccccgtat caagaaattt gccatctatc gatgggaccc agacaaggct ggagacaaac    300

ctcatatgca gacttataag gttgacctta ataaatgtgg ccccatggta ttggatgctt    360

taatcaagat taagaatgaa gttgactcta ctttgacctt ccgaagatca tgcagagaag    420

gcatctgtgg ctcttgtgca atgaacatca atggaggcaa cactctagct tgcacccgaa    480

ggattgacac caacctcaat aaggtctcaa aaatctaccc tcttccacac atgtatgtga    540

taaaggatct tgttcccgat ttgagcaact tctatgcaca gtacaaatcc attgagcctt    600

atttgaagaa gaaggatgaa tctcaggaag gcaagcagca gtatctgcag tccatagaag    660

agcgtgagaa actggacggg ctctacgagt gcattctctg tgcctgctgt agcaccagct    720

gccccagcta ctggtggaac ggagacaaat atctggggcc tgcagttctt atgcaggcct    780

atcgctggat gattgactcc agagatgact tcacagagga gcgcctggcc aagctgcagg    840

acccattctc tctataccgc tgccacacca tcatgaactg cacaaggacc tgtcctaagg    900

gtctgaatcc agggaaagct attgcagaga tcaagaaaat gatggcaacc tataaggaga    960

agaaagcttc agtttaactg tttccatgct aaacatgatt tataaccagc tcagagctga   1020

acataattta tatctaattt gagttccttt aaagatcttg gttttccatg aatacagcat   1080

gtataataaa aattttaaga                                               1100


<210>  64
<211>  280
<212>  PRT
<213>  Homosapiens

<400>  64

Met Ala Ala Val Val Ala Leu Ser Leu Arg Arg Arg Leu Pro Ala Thr 
1               5                   10                  15      


Thr Leu Gly Gly Ala Cys Leu Gln Ala Ser Arg Gly Ala Gln Thr Ala 
            20                  25                  30          


Ala Ala Thr Ala Pro Arg Ile Lys Lys Phe Ala Ile Tyr Arg Trp Asp 
        35                  40                  45              


Pro Asp Lys Ala Gly Asp Lys Pro His Met Gln Thr Tyr Lys Val Asp 
    50                  55                  60                  


Leu Asn Lys Cys Gly Pro Met Val Leu Asp Ala Leu Ile Lys Ile Lys 
65                  70                  75                  80  


Asn Glu Val Asp Ser Thr Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly 
                85                  90                  95      


Ile Cys Gly Ser Cys Ala Met Asn Ile Asn Gly Gly Asn Thr Leu Ala 
            100                 105                 110         


Cys Thr Arg Arg Ile Asp Thr Asn Leu Asn Lys Val Ser Lys Ile Tyr 
        115                 120                 125             


Pro Leu Pro His Met Tyr Val Ile Lys Asp Leu Val Pro Asp Leu Ser 
    130                 135                 140                 


Asn Phe Tyr Ala Gln Tyr Lys Ser Ile Glu Pro Tyr Leu Lys Lys Lys 
145                 150                 155                 160 


Asp Glu Ser Gln Glu Gly Lys Gln Gln Tyr Leu Gln Ser Ile Glu Glu 
                165                 170                 175     


Arg Glu Lys Leu Asp Gly Leu Tyr Glu Cys Ile Leu Cys Ala Cys Cys 
            180                 185                 190         


Ser Thr Ser Cys Pro Ser Tyr Trp Trp Asn Gly Asp Lys Tyr Leu Gly 
        195                 200                 205             


Pro Ala Val Leu Met Gln Ala Tyr Arg Trp Met Ile Asp Ser Arg Asp 
    210                 215                 220                 


Asp Phe Thr Glu Glu Arg Leu Ala Lys Leu Gln Asp Pro Phe Ser Leu 
225                 230                 235                 240 


Tyr Arg Cys His Thr Ile Met Asn Cys Thr Arg Thr Cys Pro Lys Gly 
                245                 250                 255     


Leu Asn Pro Gly Lys Ala Ile Ala Glu Ile Lys Lys Met Met Ala Thr 
            260                 265                 270         


Tyr Lys Glu Lys Lys Ala Ser Val 
        275                 280 


<210>  65
<211>  2348
<212>  DNA
<213>  Homosapiens

<400>  65
cgcacctgct gcaggtgctc ccggccgccc cggaccagcg agcgcgggca ctgcggcggg     60

gaggatgctg cgcgagcgga ccgtgcggct gcagtacggg agccgcgtgg aggcggtgta    120

cgtgctgggc acctacctct ggaccgatgt ctacagcgcg gccccagccg gggcccaaac    180

cttcagcctg aagcactcgg aacacgtgtg ggtggaggtg gtgcgtgatg gggaggctga    240

ggaggtggcc accaatggca agcagcgctg gcttctctcg cccagcacca ccctgcgggt    300

caccatgagc caggcgagca ccgaggccag cagtgacaag gtcaccgtca actactatga    360

cgaggaaggg agcattccca tcgaccaggc ggggctcttc ctcacagcca ttgagatctc    420

cctggatgtg gacgcagacc gggatggtgt ggtggagaag aacaacccaa agaaggcatc    480

ctggacctgg ggccccgagg gccagggggc catcctgctg gtgaactgtg accgagagac    540

accctggttg cccaaggagg actgccgtga tgagaaggtc tacagcaagg aagatctcaa    600

ggacatgtcc cagatgatcc tgcggaccaa aggccccgac cgcctccccg ccggatacga    660

gatagttctg tacatttcca tgtcagactc agacaaagtg ggcgtgttct acgtggagaa    720

cccgttcttc ggccaacgct atatccacat cctgggccgg cggaagctct accatgtggt    780

caagtacacg ggtggctccg cggagctgct gttcttcgtg gaaggcctct gtttccccga    840

cgagggcttc tcaggcctgg tctccatcca tgtcagcctg ctggagtaca tggcccagga    900

cattcccctg actcccatct tcacggacac cgtgatattc cggattgctc cgtggatcat    960

gacccccaac atcctgcctc ccgtgtcggt gtttgtgtgc tgcatgaagg ataattacct   1020

gttcctgaaa gaggtgaaga accttgtgga gaaaaccaac tgtgagctga aggtctgctt   1080

ccagtaccta aaccgaggcg atcgctggat ccaggatgaa attgagtttg gctacatcga   1140

ggccccccat aaaggcttcc ccgtggtgct ggactctccc cgagatggaa acctaaagga   1200

cttccctgtg aaggagctcc tgggcccaga ttttggctac gtgacccggg agcccctctt   1260

tgagtctgtc accagccttg actcatttgg aaacctggag gtcagtcccc cagtgaccgt   1320

gaacggcaag acatacccgc ttggccgcat cctcatcggg agcagctttc ctctgtctgg   1380

tggtcggagg atgaccaagg tggtgcgtga cttcctgaag gcccagcagg tgcaggcacc   1440

cgtggagctc tactcagact ggctgactgt gggccacgtg gatgagttca tgtcctttgt   1500

ccccatcccc ggcacaaaga aattcctgct actcatggcc agcacctcgg cctgctacaa   1560

gctcttccga gagaagcaga aggacggcca tggagaggcc atcatgttca aaggcttggg   1620

tgggatgagc agcaagcgaa tcaccatcaa caagattctg tccaacgaga gccttgtgca   1680

ggagaacctg tacttccagc gctgcctgga ctggaaccgt gacatcctca agaaggagct   1740

gggactgaca gagcaggaca tcattgacct gcccgctctg ttcaagatgg acgaggacca   1800

ccgtgccaga gccttcttcc caaacatggt gaacatgatc gtgctggaca aggacctggg   1860

catccccaag ccattcgggc cacaggttga ggaggaatgc tgcctggaga tgcacgtgcg   1920

tggcctcctg gagcccctgg gcctcgaatg caccttcatc gacgacattt ctgcctacca   1980

caaatttctg ggggaagtcc actgtggcac caacgtccgc aggaagccct tcaccttcaa   2040

gtggttgcac atggtgccct gacctgccag gggccctggc gtttgcctcc ttcgcttagt   2100

tctccagacc ctccctcaca cgcccagagc cttctgctga catggactgg acagccccgc   2160

tgggagacct ttgggacgtg gggtggaatt tggggtatct gtgccttgcc ctccctgaga   2220

ggggcctcag tgtcctctga agccatcccc agtgagcctc gactctgtcc ctgctgaaaa   2280

tagctgggcc agtgtctctg tagccctgac ataaggaaca gaacacaaca aaacacagca   2340

aaccatgt                                                            2348


<210>  66
<211>  665
<212>  PRT
<213>  Homosapiens

<400>  66

Met Leu Arg Glu Arg Thr Val Arg Leu Gln Tyr Gly Ser Arg Val Glu 
1               5                   10                  15      


Ala Val Tyr Val Leu Gly Thr Tyr Leu Trp Thr Asp Val Tyr Ser Ala 
            20                  25                  30          


Ala Pro Ala Gly Ala Gln Thr Phe Ser Leu Lys His Ser Glu His Val 
        35                  40                  45              


Trp Val Glu Val Val Arg Asp Gly Glu Ala Glu Glu Val Ala Thr Asn 
    50                  55                  60                  


Gly Lys Gln Arg Trp Leu Leu Ser Pro Ser Thr Thr Leu Arg Val Thr 
65                  70                  75                  80  


Met Ser Gln Ala Ser Thr Glu Ala Ser Ser Asp Lys Val Thr Val Asn 
                85                  90                  95      


Tyr Tyr Asp Glu Glu Gly Ser Ile Pro Ile Asp Gln Ala Gly Leu Phe 
            100                 105                 110         


Leu Thr Ala Ile Glu Ile Ser Leu Asp Val Asp Ala Asp Arg Asp Gly 
        115                 120                 125             


Val Val Glu Lys Asn Asn Pro Lys Lys Ala Ser Trp Thr Trp Gly Pro 
    130                 135                 140                 


Glu Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Glu Thr Pro 
145                 150                 155                 160 


Trp Leu Pro Lys Glu Asp Cys Arg Asp Glu Lys Val Tyr Ser Lys Glu 
                165                 170                 175     


Asp Leu Lys Asp Met Ser Gln Met Ile Leu Arg Thr Lys Gly Pro Asp 
            180                 185                 190         


Arg Leu Pro Ala Gly Tyr Glu Ile Val Leu Tyr Ile Ser Met Ser Asp 
        195                 200                 205             


Ser Asp Lys Val Gly Val Phe Tyr Val Glu Asn Pro Phe Phe Gly Gln 
    210                 215                 220                 


Arg Tyr Ile His Ile Leu Gly Arg Arg Lys Leu Tyr His Val Val Lys 
225                 230                 235                 240 


Tyr Thr Gly Gly Ser Ala Glu Leu Leu Phe Phe Val Glu Gly Leu Cys 
                245                 250                 255     


Phe Pro Asp Glu Gly Phe Ser Gly Leu Val Ser Ile His Val Ser Leu 
            260                 265                 270         


Leu Glu Tyr Met Ala Gln Asp Ile Pro Leu Thr Pro Ile Phe Thr Asp 
        275                 280                 285             


Thr Val Ile Phe Arg Ile Ala Pro Trp Ile Met Thr Pro Asn Ile Leu 
    290                 295                 300                 


Pro Pro Val Ser Val Phe Val Cys Cys Met Lys Asp Asn Tyr Leu Phe 
305                 310                 315                 320 


Leu Lys Glu Val Lys Asn Leu Val Glu Lys Thr Asn Cys Glu Leu Lys 
                325                 330                 335     


Val Cys Phe Gln Tyr Leu Asn Arg Gly Asp Arg Trp Ile Gln Asp Glu 
            340                 345                 350         


Ile Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Gly Phe Pro Val Val 
        355                 360                 365             


Leu Asp Ser Pro Arg Asp Gly Asn Leu Lys Asp Phe Pro Val Lys Glu 
    370                 375                 380                 


Leu Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Leu Phe Glu 
385                 390                 395                 400 


Ser Val Thr Ser Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro 
                405                 410                 415     


Val Thr Val Asn Gly Lys Thr Tyr Pro Leu Gly Arg Ile Leu Ile Gly 
            420                 425                 430         


Ser Ser Phe Pro Leu Ser Gly Gly Arg Arg Met Thr Lys Val Val Arg 
        435                 440                 445             


Asp Phe Leu Lys Ala Gln Gln Val Gln Ala Pro Val Glu Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Thr Val Gly His Val Asp Glu Phe Met Ser Phe Val Pro 
465                 470                 475                 480 


Ile Pro Gly Thr Lys Lys Phe Leu Leu Leu Met Ala Ser Thr Ser Ala 
                485                 490                 495     


Cys Tyr Lys Leu Phe Arg Glu Lys Gln Lys Asp Gly His Gly Glu Ala 
            500                 505                 510         


Ile Met Phe Lys Gly Leu Gly Gly Met Ser Ser Lys Arg Ile Thr Ile 
        515                 520                 525             


Asn Lys Ile Leu Ser Asn Glu Ser Leu Val Gln Glu Asn Leu Tyr Phe 
    530                 535                 540                 


Gln Arg Cys Leu Asp Trp Asn Arg Asp Ile Leu Lys Lys Glu Leu Gly 
545                 550                 555                 560 


Leu Thr Glu Gln Asp Ile Ile Asp Leu Pro Ala Leu Phe Lys Met Asp 
                565                 570                 575     


Glu Asp His Arg Ala Arg Ala Phe Phe Pro Asn Met Val Asn Met Ile 
            580                 585                 590         


Val Leu Asp Lys Asp Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Val 
        595                 600                 605             


Glu Glu Glu Cys Cys Leu Glu Met His Val Arg Gly Leu Leu Glu Pro 
    610                 615                 620                 


Leu Gly Leu Glu Cys Thr Phe Ile Asp Asp Ile Ser Ala Tyr His Lys 
625                 630                 635                 640 


Phe Leu Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe 
                645                 650                 655     


Thr Phe Lys Trp Leu His Met Val Pro 
            660                 665 


<210>  67
<211>  2711
<212>  DNA
<213>  Homosapiens

<400>  67
acacttcttc ctggcaaaga agtgcccagg acgggagctg gggagccagg gctgatctag     60

gaggctggga gccaggtgac aggatggccc caaagagagt tgtgcagctg tccctgaaga    120

tgcctaccca tgccgtgtgt gtggtgggag tcgaggcaca tgtggacatt cacagtgatg    180

tgcccaaggg tgccaacagc ttcagggtct ctggaagctc cggggtggag gtcttcatgg    240

tctacaaccg cacacgtgtg aaagagccca taggcaaggc ccgttggccg ctagacactg    300

atgcagacat ggtcgtatct gtgggcacag ccagtaagga attaaaggac ttcaaggtga    360

gggtctccta ctttggggag caggaagacc aagctctggg ccgcagcgtg ctttacctca    420

ctggcgtcga tatttccctt gaggttgaca caggccgcac aggcaaggtg aagaggagcc    480

aaggggacaa gaaaacctgg cgctggggcc ctgagggcta tggggctatc ttgctggtga    540

actgtgaccg ggacaatcac aggtccgcgg agcctgacct cacccacagc tggctgatgt    600

cgctggctga cctgcaggac atgtccccaa tgctgctgag ctgcaatggc cccgacaagc    660

tcttcgacag ccacaagctt gtcttgaacg tgcccttttc tgattccaaa agagtgaggg    720

tcttctgtgc caggggtggg aattctctct cggactacaa acaggtgctg gggccccagt    780

gtctgtccta tgaagttgag cgacagccag gggagcagga gatcaagttc tatgtggagg    840

ggctgacctt ccccgatgcc gatttcctag ggctggtttc cctcagtgtc agcctggtgg    900

acccggggac cctgcccgag gtgaccctct tcacagacac tgtgggcttc cgcatggccc    960

cctggatcat gacgcccaac actcagcctc ctgaggagct gtatgtgtgc agagtgatgg   1020

acactcatgg ctccaatgag aaattcctgg aggacatgtc ttatctgaca ttgaaagcca   1080

actgcaagct gaccatctgc cctcaagttg aaaatcgaaa tgaccgctgg atccaggacg   1140

agatggagtt tggctacatc gaggcccctc acaaatcctt ccccgtggtc tttgactccc   1200

ccaggaacag gggcctgaaa gatttcccct ataagaggat cctgggtcct gactttggat   1260

atgttacccg ggagatcccg ctccctggtc cctccagcct tgactccttc ggcaacctgg   1320

acgtcagccc gcccgtcacg gggggcggca cggaataccc cctgggccgg atcctcatcg   1380

ggagcagctt ccccaagtcc ggtgggcggc agatggccag ggcagtgcgg aacttcctga   1440

aggcacagca ggtgcaggca cccgtggagc tctactcgga ctggctctct gtgggccatg   1500

tggacgagtt tctgaccttt gtgcctacct ctgaccagaa gggcttccgg ctgctcctgg   1560

ctagccccag cgcttgcccc aaactcttcc aagagaagaa agaagagggt tatggggagg   1620

cagcccagtt tgatgggtta aaacaccagg caaaaagaag cattaatgag atgctggcag   1680

acagacacct ccagagagac aatcttcatg cacagaaatg cattgactgg aaccgtaatg   1740

tgctgaagcg ggagctgggc ctggcagaga gtgacatcgt ggacattccc cagctcttct   1800

tcctgaaaaa cttctacgcg gaagccttct tcccagacat ggttaacatg gtggtcttag   1860

gcaagtacct gggcatcccc aagccctacg ggcccatcat caatggccgc tgctgcctgg   1920

aggagaaggt gcagtccctg ctggagcctc tgggcctgca ctgcatcttc attgatgact   1980

acttgtccta ccacgagctg cagggggaga tccactgtgg caccaacgtg cgcaggaagc   2040

cctttccctt caaatggtgg aacatggtgc cctgagcctg cccccacccg ccatcctctc   2100

tgccctcttg ctagggaacc ctgccagggt gaaggcaagg aacaaccacc tggcctccat   2160

tctcttgggg gagtcttggc actttgcaaa catcctggcc accatgggca ccaggacaca   2220

gggatggata ccacctaccc tcgcctctgg aatggcctac ccaacccgag aagaatgcac   2280

ctcattcttc cctggcctct ttcccaccca cagcccccag aggctctaga tcaacaatgt   2340

tagcatgttc cagaatggct gtgggaggcc tagggaggtg ggccccactt agaattgctc   2400

ccccttcatt ctgatgcctc cctggggaac aaggataatg actttgcatc tgcacctgga   2460

acggggcctg ggggacctgg ggtctggtgt gccaggcacc aggctgcctc tgctcttgga   2520

aaactaggaa aggggatcag aaacatcctc tccccgctct aggtttcttc tcccaaaggg   2580

gacccaaggc tgtgacactt acctccaccc ccatccagca cccttcagct gtgtgtggac   2640

aaacaaggac agaaaaaccc agtgtccaag ggccaattta aatagaaaaa aaaaaaaaaa   2700

aaaaaaaaaa a                                                        2711


<210>  68
<211>  663
<212>  PRT
<213>  Homosapiens

<400>  68

Met Ala Pro Lys Arg Val Val Gln Leu Ser Leu Lys Met Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Val Gly Val Glu Ala His Val Asp Ile His Ser Asp 
            20                  25                  30          


Val Pro Lys Gly Ala Asn Ser Phe Arg Val Ser Gly Ser Ser Gly Val 
        35                  40                  45              


Glu Val Phe Met Val Tyr Asn Arg Thr Arg Val Lys Glu Pro Ile Gly 
    50                  55                  60                  


Lys Ala Arg Trp Pro Leu Asp Thr Asp Ala Asp Met Val Val Ser Val 
65                  70                  75                  80  


Gly Thr Ala Ser Lys Glu Leu Lys Asp Phe Lys Val Arg Val Ser Tyr 
                85                  90                  95      


Phe Gly Glu Gln Glu Asp Gln Ala Leu Gly Arg Ser Val Leu Tyr Leu 
            100                 105                 110         


Thr Gly Val Asp Ile Ser Leu Glu Val Asp Thr Gly Arg Thr Gly Lys 
        115                 120                 125             


Val Lys Arg Ser Gln Gly Asp Lys Lys Thr Trp Arg Trp Gly Pro Glu 
    130                 135                 140                 


Gly Tyr Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn His Arg 
145                 150                 155                 160 


Ser Ala Glu Pro Asp Leu Thr His Ser Trp Leu Met Ser Leu Ala Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Pro Met Leu Leu Ser Cys Asn Gly Pro Asp Lys 
            180                 185                 190         


Leu Phe Asp Ser His Lys Leu Val Leu Asn Val Pro Phe Ser Asp Ser 
        195                 200                 205             


Lys Arg Val Arg Val Phe Cys Ala Arg Gly Gly Asn Ser Leu Ser Asp 
    210                 215                 220                 


Tyr Lys Gln Val Leu Gly Pro Gln Cys Leu Ser Tyr Glu Val Glu Arg 
225                 230                 235                 240 


Gln Pro Gly Glu Gln Glu Ile Lys Phe Tyr Val Glu Gly Leu Thr Phe 
                245                 250                 255     


Pro Asp Ala Asp Phe Leu Gly Leu Val Ser Leu Ser Val Ser Leu Val 
            260                 265                 270         


Asp Pro Gly Thr Leu Pro Glu Val Thr Leu Phe Thr Asp Thr Val Gly 
        275                 280                 285             


Phe Arg Met Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro Pro Glu 
    290                 295                 300                 


Glu Leu Tyr Val Cys Arg Val Met Asp Thr His Gly Ser Asn Glu Lys 
305                 310                 315                 320 


Phe Leu Glu Asp Met Ser Tyr Leu Thr Leu Lys Ala Asn Cys Lys Leu 
                325                 330                 335     


Thr Ile Cys Pro Gln Val Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp 
            340                 345                 350         


Glu Met Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Ser Phe Pro Val 
        355                 360                 365             


Val Phe Asp Ser Pro Arg Asn Arg Gly Leu Lys Asp Phe Pro Tyr Lys 
    370                 375                 380                 


Arg Ile Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Ile Pro Leu 
385                 390                 395                 400 


Pro Gly Pro Ser Ser Leu Asp Ser Phe Gly Asn Leu Asp Val Ser Pro 
                405                 410                 415     


Pro Val Thr Gly Gly Gly Thr Glu Tyr Pro Leu Gly Arg Ile Leu Ile 
            420                 425                 430         


Gly Ser Ser Phe Pro Lys Ser Gly Gly Arg Gln Met Ala Arg Ala Val 
        435                 440                 445             


Arg Asn Phe Leu Lys Ala Gln Gln Val Gln Ala Pro Val Glu Leu Tyr 
    450                 455                 460                 


Ser Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Thr Phe Val 
465                 470                 475                 480 


Pro Thr Ser Asp Gln Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Ser 
                485                 490                 495     


Ala Cys Pro Lys Leu Phe Gln Glu Lys Lys Glu Glu Gly Tyr Gly Glu 
            500                 505                 510         


Ala Ala Gln Phe Asp Gly Leu Lys His Gln Ala Lys Arg Ser Ile Asn 
        515                 520                 525             


Glu Met Leu Ala Asp Arg His Leu Gln Arg Asp Asn Leu His Ala Gln 
    530                 535                 540                 


Lys Cys Ile Asp Trp Asn Arg Asn Val Leu Lys Arg Glu Leu Gly Leu 
545                 550                 555                 560 


Ala Glu Ser Asp Ile Val Asp Ile Pro Gln Leu Phe Phe Leu Lys Asn 
                565                 570                 575     


Phe Tyr Ala Glu Ala Phe Phe Pro Asp Met Val Asn Met Val Val Leu 
            580                 585                 590         


Gly Lys Tyr Leu Gly Ile Pro Lys Pro Tyr Gly Pro Ile Ile Asn Gly 
        595                 600                 605             


Arg Cys Cys Leu Glu Glu Lys Val Gln Ser Leu Leu Glu Pro Leu Gly 
    610                 615                 620                 


Leu His Cys Ile Phe Ile Asp Asp Tyr Leu Ser Tyr His Glu Leu Gln 
625                 630                 635                 640 


Gly Glu Ile His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Pro Phe 
                645                 650                 655     


Lys Trp Trp Asn Met Val Pro 
            660             


<210>  69
<211>  3183
<212>  DNA
<213>  Homosapiens

<400>  69
gagtgttggg gttggcggcc acagctaagt ccaacaccag catgtcgctg cagagaatcg     60

tgcgtgtgtc cctggagcat cccaccagcg cggtgtgtgt ggctggcgtg gagaccctcg    120

tggacattta tgggtcagtg cctgagggca cagaaatgtt tgaggtctat gggacgcctg    180

gcgtggacat ctacatctct cccaacatgg agaggggccg ggagcgtgca gacaccaggc    240

ggtggcgctt tgacgcgact ttggagatca tcgtggtcat gaactccccc agcaatgacc    300

tcaacgacag ccatgttcag atttcctacc actccagcca tgagcctctg cccctagcct    360

atgcggtgct ctacctcacc tgtgttgaca tctctctgga ttgcgacctg aactgtgagg    420

gaaggcagga caggaacttt gtagacaagc ggcagtgggt ctgggggccc agtgggtatg    480

gcggcatctt gctggtgaac tgtgaccgtg atgatccgag ctgtgatgtc caggacaatt    540

gtgaccagca cgtgcactgc ctgcaagacc tggaagacat gtctgtcatg gtcctgcgga    600

cgcagggccc tgcagccctc tttgatgacc acaaacttgt cctccatacc tccagctatg    660

atgccaaacg ggcacaggtc ttccacatct gcggtcctga ggatgtgtgt gaggcctata    720

ggcatgtgct gggccaagat aaggtgtcct atgaggtacc ccgcttgcat ggggatgagg    780

agcgcttctt cgtggaaggc ctgtccttcc ctgatgccgg cttcacagga ctcatctcct    840

tccatgtcac tctgctggac gactccaacg aggatttctc ggcatcccct atcttcactg    900

acactgtggt gttccgagtg gcaccctgga tcatgacgcc cagcactctg ccacccctag    960

aggtgtatgt gtgccgtgtg aggaacaaca cgtgttttgt ggatgcggtg gcagagctgg   1020

ccaggaaggc cggctgcaag ctgaccatct gcccacaggc cgagaaccgc aacgaccgct   1080

ggatccagga tgagatggag ctgggctacg ttcaggcgcc gcacaagacc ctcccggtgg   1140

tctttgactc cccaaggaat ggggaactgc aggatttccc ttacaaaaga atcctgggtc   1200

cagattttgg ttacgtgact cgggaaccac gcgacaggtc tgtgagtggc ctggactcct   1260

ttgggaacct ggaggtcagc cctccagtgg tggccaatgg gaaagagtac cccctgggga   1320

ggatcctcat tgggggcaac ctgcctgggt caagtggccg cagggtcacc caggtggtgc   1380

gggacttcct ccatgcccag aaggtgcagc cccccgtgga gctctttgtg gactggttgg   1440

ccgtgggcca tgtggatgag tttctgagct ttgtccctgt ccccgatggg aagggcttcc   1500

ggatgctcct ggccagccct ggggcctgct tcaagctctt ccaggaaaag cagaagtgtg   1560

gccacgggag ggccctcctg ttccaggggg ttgttgatga tgagcaggtc aagaccatct   1620

ccatcaacca ggtgctctcc aataaagacc tcatcaacta caataagttt gtgcagagct   1680

gcatcgactg gaaccgtgag gtgctgaagc gggagctggg cctggcagag tgtgacatca   1740

ttgacatccc acagctcttc aagaccgaga ggaaaaaagc aacggccttc ttccctgact   1800

tggtgaacat gctggtgctg gggaagcacc tgggcatccc caagcccttt gggcccatca   1860

tcaatggctg ctgctgcctg gaggagaagg tgcggtccct gctggagcct ctgggcctcc   1920

actgcacctt cattgatgac ttcactccat accacatgct gcatggggag gtgcactgtg   1980

gcaccaatgt gtgcagaaag cccttctctt tcaagtggtg gaacatggtg ccctgagaca   2040

gctcccaccc accatcctgt ccccctgggg cgggcattgg ccaggtggtg gagacagaga   2100

caggccctga acgataagca ccaagagacc caaggctcca gatggaacac tgagggtgac   2160

cgtccctctc agaagctttt ccctggagtg tcatgcctca cctgcaaccc atgtggttct   2220

cagacttgaa tcttctcggc ccccaaaaat gaaggacctc atttcttata gcctctcctg   2280

tgattcaaca caacccatgg agatgtcccc ttctcactct gaaatcatcc atttggggac   2340

aaatccacat tggggtctag aaacatccac gtatctcatc agccatcttg tcctgtgcat   2400

cctaacagag gaaggatcca tgattctgct ttggtccaat tgcttcctct ctgcagagga   2460

acaaccccaa aaccagacca ctccacgcag gacaggcagg agagattctt cctaaagcct   2520

cccccataaa aagggagctg tggatccact tagatcaggg cggaaccatc tttcacccgg   2580

ccaagctcct gcccagatgt tgaccctcac ccagcgtgag ctttcacata gtaggagctt   2640

ctagatgcat gtggaagcaa tgagagttgt cccttagcct tataaactcc ccatgatctg   2700

acatgcagaa atccagcctt gtccagaatc ctcctggaat tgcttggagg acgaaagtat   2760

gctgggggat gggtgggtac tagggagact gggtacaagg gtgaaaagta gttcccataa   2820

tacacatggt tgactatggt gatccacctt gtgatggtta atattaggtg tctggagaag   2880

gttgcttcat tggccctggg acttctctct gcaggaggag agaacgctgc ctctcctctg   2940

gattggtctc aggctctctg ttggcctttg gtcagcgttt ccacatcctg ctctgctgca   3000

ggagaggggg ctaaggggct ggatccacca aggcagctca cagcgggaaa actctgggac   3060

tgaaccactg aattcagggg atgggggtgg gggcccggtt ctcgaggtgt gtgccagcta   3120

cacgtgtgtt ctgtatgggt ccagctgcgt ttccatcact cgctaataaa tcaacagaaa   3180

cac                                                                 3183


<210>  70
<211>  664
<212>  PRT
<213>  Homosapiens

<400>  70

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser 
385                 390                 395                 400 


Val Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Val Ala Asn Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly 
            420                 425                 430         


Asn Leu Pro Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp 
        435                 440                 445             


Phe Leu His Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp 
    450                 455                 460                 


Trp Leu Ala Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Val 
465                 470                 475                 480 


Pro Asp Gly Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys 
                485                 490                 495     


Phe Lys Leu Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu 
            500                 505                 510         


Leu Phe Gln Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile 
        515                 520                 525             


Asn Gln Val Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val 
    530                 535                 540                 


Gln Ser Cys Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly 
545                 550                 555                 560 


Leu Ala Glu Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu 
                565                 570                 575     


Arg Lys Lys Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val 
            580                 585                 590         


Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn 
        595                 600                 605             


Gly Cys Cys Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu 
    610                 615                 620                 


Gly Leu His Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu 
625                 630                 635                 640 


His Gly Glu Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser 
                645                 650                 655     


Phe Lys Trp Trp Asn Met Val Pro 
            660                 


<210>  71
<211>  2263
<212>  DNA
<213>  Homosapiens

<400>  71
agccagaggg acgagctagc ccgacgatgg cccaggggac attgatccgt gtgaccccag     60

agcagcccac ccatgccgtg tgtgtgctgg gcaccttgac tcagcttgac atctgcagct    120

ctgcccctga ggactgcacg tccttcagca tcaacgcctc cccaggggtg gtcgtggata    180

ttgcccacag ccctccagcc aagaagaaat ccacaggttc ctccacatgg cccctggacc    240

ctggggtaga ggtgaccctg acgatgaaag cggccagtgg tagcacaggc gaccagaagg    300

ttcagatttc atactacgga cccaagactc caccagtcaa agctctactc tacctcaccg    360

cggtggaaat ctccctgtgc gcagacatca cccgcaccgg caaagtgaag ccaaccagag    420

ctgtgaaaga tcagaggacc tggacctggg gcccttgtgg acagggtgcc atcctgctgg    480

tgaactgtga cagagacaat ctcgaatctt ctgccatgga ctgcgaggat gatgaagtgc    540

ttgacagcga agacctgcag gacatgtcgc tgatgaccct gagcacgaag acccccaagg    600

acttcttcac aaaccataca ctggtgctcc acgtggccag gtctgagatg gacaaagtga    660

gggtgtttca ggccacacgg ggcaaactgt cctccaagtg cagcgtagtc ttgggtccca    720

agtggccctc tcactacctg atggtccccg gtggaaagca caacatggac ttctacgtgg    780

aggccctcgc tttcccggac accgacttcc cggggctcat taccctcacc atctccctgc    840

tggacacgtc caacctggag ctccccgagg ctgtggtgtt ccaagacagc gtggtcttcc    900

gcgtggcgcc ctggatcatg acccccaaca cccagccccc gcaggaggtg tacgcgtgca    960

gtatttttga aaatgaggac ttcctgaagt cagtgactac tctggccatg aaagccaagt   1020

gcaagctgac catctgccct gaggaggaga acatggatga ccagtggatg caggatgaaa   1080

tggagatcgg ctacatccaa gccccacaca aaacgctgcc cgtggtcttc gactctccaa   1140

ggaacagagg cctgaaggag tttcccatca aacgagtgat gggtccagat tttggctatg   1200

taactcgagg gccccaaaca gggggtatca gtggactgga ctcctttggg aacctggaag   1260

tgagcccccc agtcacagtc aggggcaagg aatacccgct gggcaggatt ctcttcgggg   1320

acagctgtta tcccagcaat gacagccggc agatgcacca ggccctgcag gacttcctca   1380

gtgcccagca ggtgcaggcc cctgtgaagc tctattctga ctggctgtcc gtgggccacg   1440

tggacgagtt cctgagcttt gtgccagcac ccgacaggaa gggcttccgg ctgctcctgg   1500

ccagccccag gtcctgctac aaactgttcc aggagcagca gaatgagggc cacggggagg   1560

ccctgctgtt cgaagggatc aagaaaaaaa aacagcagaa aataaagaac attctgtcaa   1620

acaagacatt gagagaacat aattcatttg tggagagatg catcgactgg aaccgcgagc   1680

tgctgaagcg ggagctgggc ctggccgaga gtgacatcat tgacatcccg cagctcttca   1740

agctcaaaga gttctctaag gcggaagctt ttttccccaa catggtgaac atgctggtgc   1800

tagggaagca cctgggcatc cccaagccct tcgggcccgt catcaacggc cgctgctgcc   1860

tggaggagaa ggtgtgttcc ctgctggagc cactgggcct ccagtgcacc ttcatcaacg   1920

acttcttcac ctaccacatc aggcatgggg aggtgcactg cggcaccaac gtgcgcagaa   1980

agcccttctc cttcaagtgg tggaacatgg tgccctgagc ccatcttccc tggcgtcctc   2040

tccctcctgg ccagatgtcg ctgggtcctc tgcagtgtgg caagcaagag ctcttgtgaa   2100

tattgtggct ccctgggggc ggccagccct cccagcagtg gcttgctttc ttctcctgtg   2160

atgtcccagt ttcccactct gaagatccca acatggtcct agcactgcac actcagttct   2220

gctctaagaa gctgcaataa agttttttta agtcactttg tac                     2263


<210>  72
<211>  663
<212>  PRT
<213>  Homosapiens

<400>  72

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Ser Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Ala Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Ala 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Gly Pro Asp Phe Gly Tyr Val Thr Arg Gly Pro Gln Thr Gly Gly 
385                 390                 395                 400 


Ile Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Thr Val Arg Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Phe Gly Asp 
            420                 425                 430         


Ser Cys Tyr Pro Ser Asn Asp Ser Arg Gln Met His Gln Ala Leu Gln 
        435                 440                 445             


Asp Phe Leu Ser Ala Gln Gln Val Gln Ala Pro Val Lys Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro 
465                 470                 475                 480 


Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser 
                485                 490                 495     


Cys Tyr Lys Leu Phe Gln Glu Gln Gln Asn Glu Gly His Gly Glu Ala 
            500                 505                 510         


Leu Leu Phe Glu Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile Lys Asn 
        515                 520                 525             


Ile Leu Ser Asn Lys Thr Leu Arg Glu His Asn Ser Phe Val Glu Arg 
    530                 535                 540                 


Cys Ile Asp Trp Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly Leu Ala 
545                 550                 555                 560 


Glu Ser Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys Glu Phe 
                565                 570                 575     


Ser Lys Ala Glu Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu 
            580                 585                 590         


Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Val Ile Asn Gly 
        595                 600                 605             


Arg Cys Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly 
    610                 615                 620                 


Leu Gln Cys Thr Phe Ile Asn Asp Phe Phe Thr Tyr His Ile Arg His 
625                 630                 635                 640 


Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Ser Phe 
                645                 650                 655     


Lys Trp Trp Asn Met Val Pro 
            660             


<210>  73
<211>  2397
<212>  DNA
<213>  Homosapiens

<400>  73
agggcgtctg aggctgctgt gctgagtgag ggctgcggtg caggcctgag gatggtcagc     60

gtggagggcc gagccatgtc cttccagagt atcatccacc tgtccctgga cagccctgtc    120

catgccgttt gtgtgttggg cacagaaatc tgcttggatc tcagcgggtg tgccccccag    180

aagtgccagt gcttcaccat ccatggctct gggagggtct tgatcgatgt ggccaacacg    240

gtgatttctg agaaggagga cgccaccatc tggtggcccc tgtctgatcc cacgtacgcc    300

acagtgaaga tgacatcgcc cagcccttcc gtggatgcgg ataaggtctc ggtcacatac    360

tatgggccca acgaggatgc ccccgtgggc acagctgtgc tgtacctcac tggcattgag    420

gtctctctag aggtagacat ctaccgcaat gggcaagttg agatgtcaag tgacaaacag    480

gctaagaaaa aatggatctg gggtcccagc ggttggggtg ccatcctgct tgtgaattgc    540

aaccctgctg atgtgggcca gcaacttgag gacaagaaaa ccaagaaagt gatcttttca    600

gaggaaataa cgaatctgtc ccagatgact ctgaatgtcc aaggccccag ctgtatctta    660

aagaaatatc ggctagtcct ccatacctcc aaggaagagt cgaagaaggc gagagtctac    720

tggccccaaa aagacaactc cagtaccttt gagttggtgc tggggcccga ccagcacgcc    780

tataccttgg ccctcctcgg gaaccacttg aaggagactt tctacgttga agctatagca    840

ttcccatctg ccgaattctc aggcctcatc tcctactctg tgtccctggt ggaggagtct    900

caagacccgt caattccaga gactgtgctg tacaaagaca cggtggtgtt ccgggtggct    960

ccctgtgtct tcattccctg tacccaggtg cctctggagg tttacctgtg cagggagctg   1020

cagctgcagg gttttgtgga cacagtgacg aagctgagtg agaagagcaa cagccaggtg   1080

gcatctgtct atgaggaccc caaccgcctg ggcaggtggc tccaggatga gatggccttc   1140

tgctacaccc aggctcccca caagacaacg tccttgatcc tcgacacacc tcaggccgcc   1200

gatctcgatg agttccccat gaagtactca ctgagccctg gtattggcta catgatccag   1260

gacactgagg accataaagt ggccagcatg gattccattg ggaacctgat ggtgtcccca   1320

cctgtcaagg tccaagggaa agagtacccg ctgggcagag tcctcattgg cagcagcttt   1380

taccccagtg cagagggccg ggccatgagt aagaccctcc gagacttcct ctatgcccag   1440

caggtccaag cgccggtgga gctctactca gattggctaa tgactggcca cgtggatgag   1500

ttcatgtgct ccatccccac agatgacaag aatgagggca aaaagggctt cctgctgctc   1560

ctggccagcc ccagtgcctg ctataaactg ttccgagaga accagaagga aggctatggc   1620

gacgctcttc tgtttgatga gcttagagca gatcagctcc tgtctaatgg aagggaagcc   1680

aaaaccatcg accaacttct ggctgatgaa agcctgaaga agcagaatga atacgtggag   1740

aagtgcattc acctgaaccg tgacatcctg aagacggagc tgggcctggt ggaacaggac   1800

atcatcgaga ttccccagct gttctgcttg gagaagctga ctaacatccc ctctgaccag   1860

cagcccaaga ggtcctttgc gaggccatac ttccctgacc tgttgcggat gattgtgatg   1920

ggcaagaacc tggggatccc caagcctttt gggccccaaa tcaaggggac ctgctgcctg   1980

gaagaaaaga tttgctgctt gctggagccc ctgggcttca agtgcacctt catcaatgac   2040

tttgactgtt acctgacaga ggtcggagac atctgtgcct gtgccaacat ccgccgggtg   2100

ccctttgcct tcaaatggtg gaagatggta ccttagaccc aggccctgga gctgccagct   2160

ctgccccagc gtggatggcc cactgtcacc atgcaacagc atgattcttt gcccagtaga   2220

ggaggctgga gagtccaggc aacagaaccc tttcttccct gtctgccccg accgaccctc   2280

ggacccagta ggatggcaaa tgccgccagc ttgaacccct atggggaaaa gatgcaaaag   2340

tgttcagcca agtgacgttt actaaatagc caataaaggg ctggtgggtg tgaatgc      2397


<210>  74
<211>  694
<212>  PRT
<213>  Homosapiens

<400>  74

Met Val Ser Val Glu Gly Arg Ala Met Ser Phe Gln Ser Ile Ile His 
1               5                   10                  15      


Leu Ser Leu Asp Ser Pro Val His Ala Val Cys Val Leu Gly Thr Glu 
            20                  25                  30          


Ile Cys Leu Asp Leu Ser Gly Cys Ala Pro Gln Lys Cys Gln Cys Phe 
        35                  40                  45              


Thr Ile His Gly Ser Gly Arg Val Leu Ile Asp Val Ala Asn Thr Val 
    50                  55                  60                  


Ile Ser Glu Lys Glu Asp Ala Thr Ile Trp Trp Pro Leu Ser Asp Pro 
65                  70                  75                  80  


Thr Tyr Ala Thr Val Lys Met Thr Ser Pro Ser Pro Ser Val Asp Ala 
                85                  90                  95      


Asp Lys Val Ser Val Thr Tyr Tyr Gly Pro Asn Glu Asp Ala Pro Val 
            100                 105                 110         


Gly Thr Ala Val Leu Tyr Leu Thr Gly Ile Glu Val Ser Leu Glu Val 
        115                 120                 125             


Asp Ile Tyr Arg Asn Gly Gln Val Glu Met Ser Ser Asp Lys Gln Ala 
    130                 135                 140                 


Lys Lys Lys Trp Ile Trp Gly Pro Ser Gly Trp Gly Ala Ile Leu Leu 
145                 150                 155                 160 


Val Asn Cys Asn Pro Ala Asp Val Gly Gln Gln Leu Glu Asp Lys Lys 
                165                 170                 175     


Thr Lys Lys Val Ile Phe Ser Glu Glu Ile Thr Asn Leu Ser Gln Met 
            180                 185                 190         


Thr Leu Asn Val Gln Gly Pro Ser Cys Ile Leu Lys Lys Tyr Arg Leu 
        195                 200                 205             


Val Leu His Thr Ser Lys Glu Glu Ser Lys Lys Ala Arg Val Tyr Trp 
    210                 215                 220                 


Pro Gln Lys Asp Asn Ser Ser Thr Phe Glu Leu Val Leu Gly Pro Asp 
225                 230                 235                 240 


Gln His Ala Tyr Thr Leu Ala Leu Leu Gly Asn His Leu Lys Glu Thr 
                245                 250                 255     


Phe Tyr Val Glu Ala Ile Ala Phe Pro Ser Ala Glu Phe Ser Gly Leu 
            260                 265                 270         


Ile Ser Tyr Ser Val Ser Leu Val Glu Glu Ser Gln Asp Pro Ser Ile 
        275                 280                 285             


Pro Glu Thr Val Leu Tyr Lys Asp Thr Val Val Phe Arg Val Ala Pro 
    290                 295                 300                 


Cys Val Phe Ile Pro Cys Thr Gln Val Pro Leu Glu Val Tyr Leu Cys 
305                 310                 315                 320 


Arg Glu Leu Gln Leu Gln Gly Phe Val Asp Thr Val Thr Lys Leu Ser 
                325                 330                 335     


Glu Lys Ser Asn Ser Gln Val Ala Ser Val Tyr Glu Asp Pro Asn Arg 
            340                 345                 350         


Leu Gly Arg Trp Leu Gln Asp Glu Met Ala Phe Cys Tyr Thr Gln Ala 
        355                 360                 365             


Pro His Lys Thr Thr Ser Leu Ile Leu Asp Thr Pro Gln Ala Ala Asp 
    370                 375                 380                 


Leu Asp Glu Phe Pro Met Lys Tyr Ser Leu Ser Pro Gly Ile Gly Tyr 
385                 390                 395                 400 


Met Ile Gln Asp Thr Glu Asp His Lys Val Ala Ser Met Asp Ser Ile 
                405                 410                 415     


Gly Asn Leu Met Val Ser Pro Pro Val Lys Val Gln Gly Lys Glu Tyr 
            420                 425                 430         


Pro Leu Gly Arg Val Leu Ile Gly Ser Ser Phe Tyr Pro Ser Ala Glu 
        435                 440                 445             


Gly Arg Ala Met Ser Lys Thr Leu Arg Asp Phe Leu Tyr Ala Gln Gln 
    450                 455                 460                 


Val Gln Ala Pro Val Glu Leu Tyr Ser Asp Trp Leu Met Thr Gly His 
465                 470                 475                 480 


Val Asp Glu Phe Met Cys Ser Ile Pro Thr Asp Asp Lys Asn Glu Gly 
                485                 490                 495     


Lys Lys Gly Phe Leu Leu Leu Leu Ala Ser Pro Ser Ala Cys Tyr Lys 
            500                 505                 510         


Leu Phe Arg Glu Asn Gln Lys Glu Gly Tyr Gly Asp Ala Leu Leu Phe 
        515                 520                 525             


Asp Glu Leu Arg Ala Asp Gln Leu Leu Ser Asn Gly Arg Glu Ala Lys 
    530                 535                 540                 


Thr Ile Asp Gln Leu Leu Ala Asp Glu Ser Leu Lys Lys Gln Asn Glu 
545                 550                 555                 560 


Tyr Val Glu Lys Cys Ile His Leu Asn Arg Asp Ile Leu Lys Thr Glu 
                565                 570                 575     


Leu Gly Leu Val Glu Gln Asp Ile Ile Glu Ile Pro Gln Leu Phe Cys 
            580                 585                 590         


Leu Glu Lys Leu Thr Asn Ile Pro Ser Asp Gln Gln Pro Lys Arg Ser 
        595                 600                 605             


Phe Ala Arg Pro Tyr Phe Pro Asp Leu Leu Arg Met Ile Val Met Gly 
    610                 615                 620                 


Lys Asn Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Ile Lys Gly Thr 
625                 630                 635                 640 


Cys Cys Leu Glu Glu Lys Ile Cys Cys Leu Leu Glu Pro Leu Gly Phe 
                645                 650                 655     


Lys Cys Thr Phe Ile Asn Asp Phe Asp Cys Tyr Leu Thr Glu Val Gly 
            660                 665                 670         


Asp Ile Cys Ala Cys Ala Asn Ile Arg Arg Val Pro Phe Ala Phe Lys 
        675                 680                 685             


Trp Trp Lys Met Val Pro 
    690                 


<210>  75
<211>  4114
<212>  DNA
<213>  Homosapiens

<400>  75
ttgatgaaac gcggatccag acgctgcgtt tgctggcttt gatgaaacgc acatgtgttt     60

ctgttttgtg ttgtagcatt tgttctggaa gctcgtattt acattttaag tgtatctggt    120

gagtgggctg gagccctcgt ctgggccgga aaaaaaaaag ccctccgatc cgtcttttag    180

ttgcttctct tccttttttc tctccggttt ctcatcactc caaccagccg cgaccatgcc    240

caggaagaag gcggcggcgg cggcctggga ggagccgagc tcgggcaacg gcactgcccg    300

cgccgggccc aggaaacgcg gcggcccggc gggcaggaag cgcgagcggc ccgagcgctg    360

cagtagcagc agcggcggcg gcagcagcgg cgacgaggac ggcctggagc tcgacggggc    420

ccccggcggg ggcaagcgcg cggcgcggcc ggcgacagca ggcaaggcgg gcggcgcggc    480

cgtggtcatc accgaacccg agcacaccaa ggagcgcgtc aaacttgaag ggtcaaagtg    540

caaagggcag cttttgattt ttggggcaac caactgggac ttgattggtc gaaaagaagt    600

gcctaaacag caagctgctt accgcaatct cggtcagaat ttgtgggggc cccacagata    660

tgggtgcctg gcgggggtcc gggtgcggac agtggtctcg ggctcgtgtg ctgcacacag    720

cctcctcatc accacggaag ggaagctgtg gagctggggt cgaaatgaga aggggcagct    780

gggacatggt gacaccaaga gagtagaagc ccctagactc atcgagggtc ttagccacga    840

agtgattgtg tctgcagcat gtgggcggaa ccacaccttg gccttgacgg aaacgggctc    900

cgtgtttgcg tttggggaaa acaagatggg gcagctgggc cttggcaacc agacagacgc    960

tgttcccagc cccgcgcaga taatgtacaa cggccagcca attaccaaaa tggcctgtgg   1020

ggctgaattc agtatgataa tggactgcaa aggaaacctc tattcctttg ggtgccctga   1080

atatggtcag ctgggacaca actcagatgg gaagttcatc gcccgggcac agcggataga   1140

gtacgactgt gaactagttc cccggcgagt ggccatcttc attgagaaga cgaaagatgg   1200

acagattctg cctgtaccaa acgtggttgt acgagacgtg gcctgtggcg ctaaccacac   1260

gctggtcctg gactcccaga agcgagtctt ctcctggggc tttggtggct atggccggct   1320

gggccacgca gagcagaagg atgagatggt cccccgcctg gtgaagctgt ttgacttccc   1380

tgggcgtggg gcttcccaga tctatgctgg ttacacctgc tcctttgctg tcagtgaagt   1440

gggtggtctg tttttctggg gggccaccaa cacctcccgt gaatctacca tgtacccaaa   1500

agcagtgcag gacctctgcg gctggagaat tcggagcctg gcttgtggga agagcagcat   1560

cattgtggcc gccgatgaga gcaccatcag ctggggtccg tcaccgacct ttggggaact   1620

gggctacggg gaccacaagc ccaagtcttc cactgcagcc caggaggtaa agactctgga   1680

tggcattttc tcagagcagg tcgccatggg ctactcacac tccttggtga tagcaagaga   1740

tgaaagtgag actgagaaag agaagatcaa gaaactgcca gaatacaacc cccgaaccct   1800

ctgatgctcc cggagactcc tccgactcca cacctctcgc ggcagctgtc atttccatgt   1860

gcactgggac gggaagtcaa acgaggaatt taaaaaagca aaagttgacc gaaggtgcat   1920

ttttgtttag actccctgag gttccgtttt acacatgatc caacgttaac tacctttttt   1980

tctgtatgct ttccaaagtc cttttttttc ccttaatgtt gaattaaaat acttgctcat   2040

agttgattta ccattcctac aaaagaggca gaaactttga gcaatctagg tttttttttt   2100

tttttttaag ttttttcttt cttcctttcc tgaatacact ccccaaaaca cccctttcca   2160

gttacaatta gcatcgtgat ccaagcagat gccacatgga agaggaatcg ccatttactc   2220

agaaaaaatg tcccttacag gaaccggcag cagctaggca gtcaccggcc cgcctccatc   2280

caaaatcacg ctcgcgtgct tcggaagcat ccgggtcact ccttctccgc tttttcttgc   2340

agatgggcct aggccggtgt cggttctgtt tctccccttg gctgcctgta cgcccacagc   2400

cttctggctg cgacattata gaatcggccg tgtcccccct ggtgggggat tggggatctg   2460

tgtttagcca tttatatcta ctttagctgt taaagaggtc caaatgaaaa tcaggtgatt   2520

gtggaaccat ggggacttgg gggtggggca gaggtgggaa catttgtatc agttgagtca   2580

gcttggtggc tccctgtgga gccagggctg agccttgtca cgcgcactcg ccaattaaga   2640

gatggaccag ccagcagtca agtgcattct ccagtccttg caagaaggat cagccctttc   2700

tgtgccagcc tcgatcgcct tgtgctttgg tctctttttc tcccccccgc ctggatcctg   2760

cctcgcgcgg gccgtcctgt tgctgagact cggggtaccg ttctgctgac ccagctccct   2820

ttagtcacgt ttgcttggct ctggtaccaa atagttggga ttaccgaaga gtccccttcc   2880

ttgcgtgtca gcacggatgc tgtgactgcc acctgcgtcc tcgtcaagtg cccgagctcg   2940

ccgccgtgtg tgctgcgctg agtgagttat gaggtgcctt tcccggaacc ctcctctcgc   3000

ctggacccaa gagaggcgac agctgtggct ggggctcttg gtttccagag ggtctggact   3060

ggtttgggtg ctttaaaata gatatttagt tcagtggtgc ttatggggga gatgggacta   3120

gaacttaagt gtgagacttg ggtggatggg aaagttaaat attggtctct tcaagttttt   3180

tttttctttt gctttgttac cacttgtcac tgtctccatg ttaaaatgcc aaaaatgatg   3240

tagttgttgt tgcttttttc cctattttcc accccagtcg ctccttaccg tgactcctgc   3300

ccttggaggg catgtagcag tgtctgtcct gccagtccca aggccctgtg ggaggagact   3360

ggcctgcatc tctctaagac ttagtctgac gccacgcgca tctcttgttc tgtgttcaat   3420

cagtagtcca ggggagaagc ttctgctact tcagagcttt gctaaactaa cctaatttgt   3480

ccaaatcacc ccaaaaccac catctctgac gtaagcttcc atgcgacagc ctgatccgtt   3540

tccctggaca ggtctctttc ctggaatgca gcccaggcac ctgtgctcct ggcacccttg   3600

aggtctctcc tttgagccgt ggtcaccgag agggttgagg acgcagcacc cgaggtccca   3660

gcctttgcag gagcctccct gggcttagct ggacttagat cttcggtggc ctcatgtaaa   3720

cgtggcagcc agcctcttct agaaccctag cccagggact ggagcaggaa agggaccttc   3780

aaagtgaaga ctgccttgtc ccgcagctcc ttctggctta gattgaaaca tgggcttcct   3840

aatgggttaa atcctttaaa acaaggagtt gtgggggaag ggtgtcgtgc actcctagag   3900

aaaggtacac agttgcccgg ttgggaatgt gcttggcgct gaccctgcgg gcatctgact   3960

ggtcttccag ctcaggaaaa agaatttgaa agaggcttag cgtgaagggg aatcaaagag   4020

gaggttgtga tttggtcgaa ggtgcctggt ttagtgctgt aattgtctta ttattttttt   4080

tatatatata tttcttggag taaacatttt aaat                               4114


<210>  76
<211>  522
<212>  PRT
<213>  Homosapiens

<400>  76

Met Pro Arg Lys Lys Ala Ala Ala Ala Ala Trp Glu Glu Pro Ser Ser 
1               5                   10                  15      


Gly Asn Gly Thr Ala Arg Ala Gly Pro Arg Lys Arg Gly Gly Pro Ala 
            20                  25                  30          


Gly Arg Lys Arg Glu Arg Pro Glu Arg Cys Ser Ser Ser Ser Gly Gly 
        35                  40                  45              


Gly Ser Ser Gly Asp Glu Asp Gly Leu Glu Leu Asp Gly Ala Pro Gly 
    50                  55                  60                  


Gly Gly Lys Arg Ala Ala Arg Pro Ala Thr Ala Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Ala Ala Val Val Ile Thr Glu Pro Glu His Thr Lys Glu Arg Val Lys 
                85                  90                  95      


Leu Glu Gly Ser Lys Cys Lys Gly Gln Leu Leu Ile Phe Gly Ala Thr 
            100                 105                 110         


Asn Trp Asp Leu Ile Gly Arg Lys Glu Val Pro Lys Gln Gln Ala Ala 
        115                 120                 125             


Tyr Arg Asn Leu Gly Gln Asn Leu Trp Gly Pro His Arg Tyr Gly Cys 
    130                 135                 140                 


Leu Ala Gly Val Arg Val Arg Thr Val Val Ser Gly Ser Cys Ala Ala 
145                 150                 155                 160 


His Ser Leu Leu Ile Thr Thr Glu Gly Lys Leu Trp Ser Trp Gly Arg 
                165                 170                 175     


Asn Glu Lys Gly Gln Leu Gly His Gly Asp Thr Lys Arg Val Glu Ala 
            180                 185                 190         


Pro Arg Leu Ile Glu Gly Leu Ser His Glu Val Ile Val Ser Ala Ala 
        195                 200                 205             


Cys Gly Arg Asn His Thr Leu Ala Leu Thr Glu Thr Gly Ser Val Phe 
    210                 215                 220                 


Ala Phe Gly Glu Asn Lys Met Gly Gln Leu Gly Leu Gly Asn Gln Thr 
225                 230                 235                 240 


Asp Ala Val Pro Ser Pro Ala Gln Ile Met Tyr Asn Gly Gln Pro Ile 
                245                 250                 255     


Thr Lys Met Ala Cys Gly Ala Glu Phe Ser Met Ile Met Asp Cys Lys 
            260                 265                 270         


Gly Asn Leu Tyr Ser Phe Gly Cys Pro Glu Tyr Gly Gln Leu Gly His 
        275                 280                 285             


Asn Ser Asp Gly Lys Phe Ile Ala Arg Ala Gln Arg Ile Glu Tyr Asp 
    290                 295                 300                 


Cys Glu Leu Val Pro Arg Arg Val Ala Ile Phe Ile Glu Lys Thr Lys 
305                 310                 315                 320 


Asp Gly Gln Ile Leu Pro Val Pro Asn Val Val Val Arg Asp Val Ala 
                325                 330                 335     


Cys Gly Ala Asn His Thr Leu Val Leu Asp Ser Gln Lys Arg Val Phe 
            340                 345                 350         


Ser Trp Gly Phe Gly Gly Tyr Gly Arg Leu Gly His Ala Glu Gln Lys 
        355                 360                 365             


Asp Glu Met Val Pro Arg Leu Val Lys Leu Phe Asp Phe Pro Gly Arg 
    370                 375                 380                 


Gly Ala Ser Gln Ile Tyr Ala Gly Tyr Thr Cys Ser Phe Ala Val Ser 
385                 390                 395                 400 


Glu Val Gly Gly Leu Phe Phe Trp Gly Ala Thr Asn Thr Ser Arg Glu 
                405                 410                 415     


Ser Thr Met Tyr Pro Lys Ala Val Gln Asp Leu Cys Gly Trp Arg Ile 
            420                 425                 430         


Arg Ser Leu Ala Cys Gly Lys Ser Ser Ile Ile Val Ala Ala Asp Glu 
        435                 440                 445             


Ser Thr Ile Ser Trp Gly Pro Ser Pro Thr Phe Gly Glu Leu Gly Tyr 
    450                 455                 460                 


Gly Asp His Lys Pro Lys Ser Ser Thr Ala Ala Gln Glu Val Lys Thr 
465                 470                 475                 480 


Leu Asp Gly Ile Phe Ser Glu Gln Val Ala Met Gly Tyr Ser His Ser 
                485                 490                 495     


Leu Val Ile Ala Arg Asp Glu Ser Glu Thr Glu Lys Glu Lys Ile Lys 
            500                 505                 510         


Lys Leu Pro Glu Tyr Asn Pro Arg Thr Leu 
        515                 520         


<210>  77
<211>  4269
<212>  DNA
<213>  Homosapiens

<400>  77
gtgtgtagct gggacggtgc tggtctgagc tggaccttgt ctgatggctt cctccaaccc     60

tcctccacag cctgccatag gagatcagct ggttccagga gtcccaggcc cctcctctga    120

ggcagaggac gacccaggag aggcgtttga gtttgatgac agtgatgatg aagaggacac    180

cagcgcagcc ctgggcgtcc ccagccttgc tcctgagagg gacacagacc ccccactgat    240

ccacttggac tccatccctg tcactgaccc agacccagca gctgctccac ccggcacagg    300

ggtgccagcc tgggtgagca atggggatgc agcggacgca gccttctccg gggcccggca    360

ctccagctgg aagcggaaga gttcccgtcg cattgaccgg ttcactttcc ccgccctgga    420

agaggatgtg atttatgacg acgtcccctg cgagagccca gatgcgcatc agcccggggc    480

agagaggaac ctgctctacg aggatgcgca ccgggctggg gcccctcggc aggcggagga    540

cctaggctgg agctccagtg agttcgagag ctacagcgag gactcggggg aggaggccaa    600

gccggaggtc gaggtcgagc ccgccaagca ccgagtgtcc ttccagccca agatgaccca    660

gctcatgaag gccgccaaga gcgggaccaa ggatgggctg gagaagacac ggatggccgt    720

gatgcgcaaa gtctccttcc tgcacaggaa ggacgtcctc ggtgactcgg aggaggagga    780

catggggctc ctggaggtca gcgtttcgga catcaagccc ccagccccag agctgggccc    840

catgccagag ggcctgagcc ctcagcaggt ggtccggagg catatcctgg gctccatcgt    900

gcagagcgaa ggcagctacg tggagtctct gaagcggata ctccaggact accgcaaccc    960

cctgatggag atggagccca aggcgctgag cgcccgcaag tgccaggtgg tgttcttccg   1020

cgtgaaggag atcctgcact gccactccat gttccagatc gccctgtcct cccgcgtggc   1080

tgagtgggat tccaccgaga agatcgggga cctcttcgtg gcctcgtttt ccaagtccat   1140

ggtgctagat gtgtacagtg actacgtgaa caacttcacc agtgccatgt ccatcatcaa   1200

gaaggcctgc ctcaccaagc ctgccttcct cgagttcctc aagcgacggc aggtgtgcag   1260

cccagaccgt gtcaccctct acgggctgat ggtcaagccc atccagaggt tcccacagtt   1320

catactcctg cttcaggaca tgctgaagaa cacccccagg ggccatccgg acaggctgtc   1380

gctgcagctg gccctcacag agctggagac gctggctgag aagctgaacg agcagaagcg   1440

gctggctgac caggtggctg agatccagca gctgaccaag agcgtcagtg accgcagcag   1500

cctcaacaag ctgttgacct caggccagcg gcagctgctc ctgtgtgaga cgttgacgga   1560

gaccgtgtac ggtgaccgcg ggcagctaat taagtccaag gagcgtcggg tcttcctgct   1620

caacgacatg cttgtctgtg ccaacatcaa cttcaagcct gccaaccaca ggggccagct   1680

ggagatcagc agcctggtgc ccctggggcc caagtatgtg gtgaagtgga acacggcgct   1740

gccccaggtg caggtggtgg aggtgggcca ggacggtggc acctatgaca aggacaatgt   1800

gctcatccag cactcaggcg ccaagaaggc ctctgcctca gggcaggctc agaataaggt   1860

gtacctcggc cccccacgcc tcttccagga gctgcaggac ctgcagaagg acctggccgt   1920

ggtggagcag atcacgcttc tcatcagcac gctgcacggc acctaccaga acctgaacat   1980

gactgtggct caagactggt gcctggccct gcagaggctg atgcgggtga aggaggaaga   2040

gatccactcg gccaacaagt gccgtctcag gctcctgctt cctgggaaac ccgacaagtc   2100

cggccgcccc attagcttca tggtggtttt catcaccccc aaccccctga gcaagatttc   2160

ctgggtcaac aggttacatt tggccaaaat cggactccgg gaggagaacc agccaggctg   2220

gctatgcccg gatgaggaca agaagagcaa agccccattc tggtgcccga tcctggcctg   2280

ctgcatccct gccttctcct cccgggcact cagcctgcag cttggggccc tggtccacag   2340

tcctgtcaac tgtcccctgc tgggtttctc agcagtcagc acctcccttc cacagggcta   2400

cctctgggtc gggggcggac aggaaggcgc agggggccag gtggaaatct tttccttgaa   2460

ccggccctcg ccccgcaccg tcaagtcctt cccactggca gcccctgtgc tctgcatgga   2520

gtatatcccg gagctggagg aggaggcgga gagcagagac gagagcccga cagttgctga   2580

cccctcggcc acggtgcatc caaccatctg cctcgggctc caggatggca gcatcctcct   2640

ctacagcagt gtggacactg gcacccagtg cctggtgagc tgcaggagcc caggtctgca   2700

gcctgtgctc tgcctgcgac acagcccctt ccacctgctc gctggcctgc aggatgggac   2760

ccttgctgct taccctcgga ccagcggagg tgtcctgtgg gacctggaga gccctcccgt   2820

gtgcctgact gtggggcccg ggcctgtccg caccctgttg agcctggagg atgccgtgtg   2880

ggccagctgt gggccccggg tcactgtcct ggaagccacc accctgcagc ctcagcaaag   2940

cttcgaggcg caccaggacg aggcagtgag cgtgacacac atggtgaagg cgggcagcgg   3000

cgtctggatg gccttctcct ccggcacctc catccgcctc ttccacactg agaccctgga   3060

gcatctgcaa gagatcaaca tcgccaccag gaccaccttc ctcctgccag gccagaagca   3120

cttgtgtgtc accagcctcc tgatctgcca gggtctgctc tgggtgggca ctgaccaggg   3180

tgtcatcgtc ctgctgcccg tgcctcggct ggaaggcatc cccaagatca cagggaaagg   3240

catggtctca ctcaacgggc actgtgggcc tgtggccttc ctggctgtgg ctaccagcat   3300

cctggcccct gacatcctgc ggagtgacca ggaggaggct gaggggcccc gggctgagga   3360

ggacaagcca gacgggcagg cacacgagcc catgcccgat agccacgtgg gccgagagct   3420

gacccgcaag aagggcatcc tcttgcagta ccgcctgcgc tccaccgcac acctcccggg   3480

cccgctgctc tccatgcggg agccggcgcc tgctgatggc gcagctttgg agcacagcga   3540

ggaggacggc tccatttacg agatggccga cgaccccgac atctgggtgc gcagccggcc   3600

ctgcgcccgc gacgcccacc gcaaggagat ttgctctgtg gccatcatct ccggcgggca   3660

gggctaccgc aactttggca gcgctctggg cagcagtggg aggcaggccc cgtgtgggga   3720

gacggacagc accctcctca tctggcaggt gcccttgatg ctatagcgcc tcccctctcc   3780

cctcagaggg cacagctgca ggcctgacca aggccacgcc cggctctcgt gctctaggac   3840

ctgcacggga cttgtggatg ggcctggact ctccagaaac tacttgggca gagcaaagga   3900

aaacctcttg ttttaaaaaa atttttttca gagtgttttg gggaggagtt ttagggcttg   3960

gggagaggga ggacacatct ggaggaaatg gccttctttt taaaagcaaa aaacacaaaa   4020

cctcacaact gcctggcaag cccagtatca cttgtttggg ccctagcggg actccaaggc   4080

agccacacgc ccctcctgga agggtgtgtg cgtgtgagtg tgtgcgagtg tgtgggctgg   4140

tgtgtgaata tctataaata agtatatatg gtgtatatta tatgtgtata aataaagtct   4200

gtacatattg gagctctggg agatgctgga ataaaagaca agagttacat ctggacttgg   4260

aaaaaaaaa                                                           4269


<210>  78
<211>  1240
<212>  PRT
<213>  Homosapiens

<400>  78

Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala Ile Gly Asp Gln Leu 
1               5                   10                  15      


Val Pro Gly Val Pro Gly Pro Ser Ser Glu Ala Glu Asp Asp Pro Gly 
            20                  25                  30          


Glu Ala Phe Glu Phe Asp Asp Ser Asp Asp Glu Glu Asp Thr Ser Ala 
        35                  40                  45              


Ala Leu Gly Val Pro Ser Leu Ala Pro Glu Arg Asp Thr Asp Pro Pro 
    50                  55                  60                  


Leu Ile His Leu Asp Ser Ile Pro Val Thr Asp Pro Asp Pro Ala Ala 
65                  70                  75                  80  


Ala Pro Pro Gly Thr Gly Val Pro Ala Trp Val Ser Asn Gly Asp Ala 
                85                  90                  95      


Ala Asp Ala Ala Phe Ser Gly Ala Arg His Ser Ser Trp Lys Arg Lys 
            100                 105                 110         


Ser Ser Arg Arg Ile Asp Arg Phe Thr Phe Pro Ala Leu Glu Glu Asp 
        115                 120                 125             


Val Ile Tyr Asp Asp Val Pro Cys Glu Ser Pro Asp Ala His Gln Pro 
    130                 135                 140                 


Gly Ala Glu Arg Asn Leu Leu Tyr Glu Asp Ala His Arg Ala Gly Ala 
145                 150                 155                 160 


Pro Arg Gln Ala Glu Asp Leu Gly Trp Ser Ser Ser Glu Phe Glu Ser 
                165                 170                 175     


Tyr Ser Glu Asp Ser Gly Glu Glu Ala Lys Pro Glu Val Glu Val Glu 
            180                 185                 190         


Pro Ala Lys His Arg Val Ser Phe Gln Pro Lys Met Thr Gln Leu Met 
        195                 200                 205             


Lys Ala Ala Lys Ser Gly Thr Lys Asp Gly Leu Glu Lys Thr Arg Met 
    210                 215                 220                 


Ala Val Met Arg Lys Val Ser Phe Leu His Arg Lys Asp Val Leu Gly 
225                 230                 235                 240 


Asp Ser Glu Glu Glu Asp Met Gly Leu Leu Glu Val Ser Val Ser Asp 
                245                 250                 255     


Ile Lys Pro Pro Ala Pro Glu Leu Gly Pro Met Pro Glu Gly Leu Ser 
            260                 265                 270         


Pro Gln Gln Val Val Arg Arg His Ile Leu Gly Ser Ile Val Gln Ser 
        275                 280                 285             


Glu Gly Ser Tyr Val Glu Ser Leu Lys Arg Ile Leu Gln Asp Tyr Arg 
    290                 295                 300                 


Asn Pro Leu Met Glu Met Glu Pro Lys Ala Leu Ser Ala Arg Lys Cys 
305                 310                 315                 320 


Gln Val Val Phe Phe Arg Val Lys Glu Ile Leu His Cys His Ser Met 
                325                 330                 335     


Phe Gln Ile Ala Leu Ser Ser Arg Val Ala Glu Trp Asp Ser Thr Glu 
            340                 345                 350         


Lys Ile Gly Asp Leu Phe Val Ala Ser Phe Ser Lys Ser Met Val Leu 
        355                 360                 365             


Asp Val Tyr Ser Asp Tyr Val Asn Asn Phe Thr Ser Ala Met Ser Ile 
    370                 375                 380                 


Ile Lys Lys Ala Cys Leu Thr Lys Pro Ala Phe Leu Glu Phe Leu Lys 
385                 390                 395                 400 


Arg Arg Gln Val Cys Ser Pro Asp Arg Val Thr Leu Tyr Gly Leu Met 
                405                 410                 415     


Val Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln Asp 
            420                 425                 430         


Met Leu Lys Asn Thr Pro Arg Gly His Pro Asp Arg Leu Ser Leu Gln 
        435                 440                 445             


Leu Ala Leu Thr Glu Leu Glu Thr Leu Ala Glu Lys Leu Asn Glu Gln 
    450                 455                 460                 


Lys Arg Leu Ala Asp Gln Val Ala Glu Ile Gln Gln Leu Thr Lys Ser 
465                 470                 475                 480 


Val Ser Asp Arg Ser Ser Leu Asn Lys Leu Leu Thr Ser Gly Gln Arg 
                485                 490                 495     


Gln Leu Leu Leu Cys Glu Thr Leu Thr Glu Thr Val Tyr Gly Asp Arg 
            500                 505                 510         


Gly Gln Leu Ile Lys Ser Lys Glu Arg Arg Val Phe Leu Leu Asn Asp 
        515                 520                 525             


Met Leu Val Cys Ala Asn Ile Asn Phe Lys Pro Ala Asn His Arg Gly 
    530                 535                 540                 


Gln Leu Glu Ile Ser Ser Leu Val Pro Leu Gly Pro Lys Tyr Val Val 
545                 550                 555                 560 


Lys Trp Asn Thr Ala Leu Pro Gln Val Gln Val Val Glu Val Gly Gln 
                565                 570                 575     


Asp Gly Gly Thr Tyr Asp Lys Asp Asn Val Leu Ile Gln His Ser Gly 
            580                 585                 590         


Ala Lys Lys Ala Ser Ala Ser Gly Gln Ala Gln Asn Lys Val Tyr Leu 
        595                 600                 605             


Gly Pro Pro Arg Leu Phe Gln Glu Leu Gln Asp Leu Gln Lys Asp Leu 
    610                 615                 620                 


Ala Val Val Glu Gln Ile Thr Leu Leu Ile Ser Thr Leu His Gly Thr 
625                 630                 635                 640 


Tyr Gln Asn Leu Asn Met Thr Val Ala Gln Asp Trp Cys Leu Ala Leu 
                645                 650                 655     


Gln Arg Leu Met Arg Val Lys Glu Glu Glu Ile His Ser Ala Asn Lys 
            660                 665                 670         


Cys Arg Leu Arg Leu Leu Leu Pro Gly Lys Pro Asp Lys Ser Gly Arg 
        675                 680                 685             


Pro Ile Ser Phe Met Val Val Phe Ile Thr Pro Asn Pro Leu Ser Lys 
    690                 695                 700                 


Ile Ser Trp Val Asn Arg Leu His Leu Ala Lys Ile Gly Leu Arg Glu 
705                 710                 715                 720 


Glu Asn Gln Pro Gly Trp Leu Cys Pro Asp Glu Asp Lys Lys Ser Lys 
                725                 730                 735     


Ala Pro Phe Trp Cys Pro Ile Leu Ala Cys Cys Ile Pro Ala Phe Ser 
            740                 745                 750         


Ser Arg Ala Leu Ser Leu Gln Leu Gly Ala Leu Val His Ser Pro Val 
        755                 760                 765             


Asn Cys Pro Leu Leu Gly Phe Ser Ala Val Ser Thr Ser Leu Pro Gln 
    770                 775                 780                 


Gly Tyr Leu Trp Val Gly Gly Gly Gln Glu Gly Ala Gly Gly Gln Val 
785                 790                 795                 800 


Glu Ile Phe Ser Leu Asn Arg Pro Ser Pro Arg Thr Val Lys Ser Phe 
                805                 810                 815     


Pro Leu Ala Ala Pro Val Leu Cys Met Glu Tyr Ile Pro Glu Leu Glu 
            820                 825                 830         


Glu Glu Ala Glu Ser Arg Asp Glu Ser Pro Thr Val Ala Asp Pro Ser 
        835                 840                 845             


Ala Thr Val His Pro Thr Ile Cys Leu Gly Leu Gln Asp Gly Ser Ile 
    850                 855                 860                 


Leu Leu Tyr Ser Ser Val Asp Thr Gly Thr Gln Cys Leu Val Ser Cys 
865                 870                 875                 880 


Arg Ser Pro Gly Leu Gln Pro Val Leu Cys Leu Arg His Ser Pro Phe 
                885                 890                 895     


His Leu Leu Ala Gly Leu Gln Asp Gly Thr Leu Ala Ala Tyr Pro Arg 
            900                 905                 910         


Thr Ser Gly Gly Val Leu Trp Asp Leu Glu Ser Pro Pro Val Cys Leu 
        915                 920                 925             


Thr Val Gly Pro Gly Pro Val Arg Thr Leu Leu Ser Leu Glu Asp Ala 
    930                 935                 940                 


Val Trp Ala Ser Cys Gly Pro Arg Val Thr Val Leu Glu Ala Thr Thr 
945                 950                 955                 960 


Leu Gln Pro Gln Gln Ser Phe Glu Ala His Gln Asp Glu Ala Val Ser 
                965                 970                 975     


Val Thr His Met Val Lys Ala Gly Ser Gly Val Trp Met Ala Phe Ser 
            980                 985                 990         


Ser Gly Thr Ser Ile Arg Leu Phe  His Thr Glu Thr Leu  Glu His Leu 
        995                 1000                 1005             


Gln Glu  Ile Asn Ile Ala Thr  Arg Thr Thr Phe Leu  Leu Pro Gly 
    1010                 1015                 1020             


Gln Lys  His Leu Cys Val Thr  Ser Leu Leu Ile Cys  Gln Gly Leu 
    1025                 1030                 1035             


Leu Trp  Val Gly Thr Asp Gln  Gly Val Ile Val Leu  Leu Pro Val 
    1040                 1045                 1050             


Pro Arg  Leu Glu Gly Ile Pro  Lys Ile Thr Gly Lys  Gly Met Val 
    1055                 1060                 1065             


Ser Leu  Asn Gly His Cys Gly  Pro Val Ala Phe Leu  Ala Val Ala 
    1070                 1075                 1080             


Thr Ser  Ile Leu Ala Pro Asp  Ile Leu Arg Ser Asp  Gln Glu Glu 
    1085                 1090                 1095             


Ala Glu  Gly Pro Arg Ala Glu  Glu Asp Lys Pro Asp  Gly Gln Ala 
    1100                 1105                 1110             


His Glu  Pro Met Pro Asp Ser  His Val Gly Arg Glu  Leu Thr Arg 
    1115                 1120                 1125             


Lys Lys  Gly Ile Leu Leu Gln  Tyr Arg Leu Arg Ser  Thr Ala His 
    1130                 1135                 1140             


Leu Pro  Gly Pro Leu Leu Ser  Met Arg Glu Pro Ala  Pro Ala Asp 
    1145                 1150                 1155             


Gly Ala  Ala Leu Glu His Ser  Glu Glu Asp Gly Ser  Ile Tyr Glu 
    1160                 1165                 1170             


Met Ala  Asp Asp Pro Asp Ile  Trp Val Arg Ser Arg  Pro Cys Ala 
    1175                 1180                 1185             


Arg Asp  Ala His Arg Lys Glu  Ile Cys Ser Val Ala  Ile Ile Ser 
    1190                 1195                 1200             


Gly Gly  Gln Gly Tyr Arg Asn  Phe Gly Ser Ala Leu  Gly Ser Ser 
    1205                 1210                 1215             


Gly Arg  Gln Ala Pro Cys Gly  Glu Thr Asp Ser Thr  Leu Leu Ile 
    1220                 1225                 1230             


Trp Gln  Val Pro Leu Met Leu  
    1235                 1240 


<210>  79
<211>  4502
<212>  DNA
<213>  Homosapiens

<400>  79
gcgccgtccc ggccatgggc gcccgcggcg gcctgcggag ctggaggcgc ggcgccggcc     60

gccaggcgcc tttgtgagcg gcgcggacga caaaggcgcg ggcccgggca gccgaggtgt    120

gtagctggga cggtgctggt ctgagctgga ccttgtctga tggcttcctc caaccctcct    180

ccacagcctg ccataggaga tcagctggtt ccaggagtcc caggcccctc ctctgaggca    240

gaggacgacc caggagaggc gtttgagttt gatgacagtg atgatgaaga ggacaccagc    300

gcagccctgg gcgtccccag ccttgctcct gagagggaca cagacccccc actgatccac    360

ttggactcca tccctgtcac tgacccagac ccagcagctg ctccacccgg cacaggggtg    420

ccagcctggg tgagcaatgg ggatgcagcg gacgcagcct tctccggggc ccggcactcc    480

agctggaagc ggaagagttc ccgtcgcatt gaccggttca ctttccccgc cctggaagag    540

gatgtgattt atgacgacgt cccctgcgag agcccagatg cgcatcagcc cggggcagag    600

aggaacctgc tctacgagga tgcgcaccgg gctggggccc ctcggcaggc ggaggaccta    660

ggctggagct ccagtgagtt cgagagctac agcgaggact cgggggagga ggccaagccg    720

gaggtcgagg tcgagcccgc caagcaccga gtgtccttcc agcccaagct ttctccagac    780

ctgactaggc taaaggagag atacgccagg actaagagag acatcttggc tttgagagtt    840

ggggggagag acatgcagga gctgaagcac aagtacgatt gtaagatgac ccagctcatg    900

aaggccgcca agagcgggac caaggatggg ctggagaaga cacggatggc cgtgatgcgc    960

aaagtctcct tcctgcacag gaaggacgtc ctcggtgact cggaggagga ggacatgggg   1020

ctcctggagg tcagcgtttc ggacatcaag cccccagccc cagagctggg ccccatgcca   1080

gagggcctga gccctcagca ggtggtccgg aggcatatcc tgggctccat cgtgcagagc   1140

gaaggcagct acgtggagtc tctgaagcgg atactccagg actaccgcaa ccccctgatg   1200

gagatggagc ccaaggcgct gagcgcccgc aagtgccagg tggtgttctt ccgcgtgaag   1260

gagatcctgc actgccactc catgttccag atcgccctgt cctcccgcgt ggctgagtgg   1320

gattccaccg agaagatcgg ggacctcttc gtggcctcgt tttccaagtc catggtgcta   1380

gatgtgtaca gtgactacgt gaacaacttc accagtgcca tgtccatcat caagaaggcc   1440

tgcctcacca agcctgcctt cctcgagttc ctcaagcgac ggcaggtgtg cagcccagac   1500

cgtgtcaccc tctacgggct gatggtcaag cccatccaga ggttcccaca gttcatactc   1560

ctgcttcagg acatgctgaa gaacaccccc aggggccatc cggacaggct gtcgctgcag   1620

ctggccctca cagagctgga gacgctggct gagaagctga acgagcagaa gcggctggct   1680

gaccaggtgg ctgagatcca gcagctgacc aagagcgtca gtgaccgcag cagcctcaac   1740

aagctgttga cctcaggcca gcggcagctg ctcctgtgtg agacgttgac ggagaccgtg   1800

tacggtgacc gcgggcagct aattaagtcc aaggagcgtc gggtcttcct gctcaacgac   1860

atgcttgtct gtgccaacat caacttcaag cctgccaacc acaggggcca gctggagatc   1920

agcagcctgg tgcccctggg gcccaagtat gtggtgaagt ggaacacggc gctgccccag   1980

gtgcaggtgg tggaggtggg ccaggacggt ggcacctatg acaaggacaa tgtgctcatc   2040

cagcactcag gcgccaagaa ggcctctgcc tcagggcagg ctcagaataa ggtgtacctc   2100

ggccccccac gcctcttcca ggagctgcag gacctgcaga aggacctggc cgtggtggag   2160

cagatcacgc ttctcatcag cacgctgcac ggcacctacc agaacctgaa catgactgtg   2220

gctcaagact ggtgcctggc cctgcagagg ctgatgcggg tgaaggagga agagatccac   2280

tcggccaaca agtgccgtct caggctcctg cttcctggga aacccgacaa gtccggccgc   2340

cccattagct tcatggtggt tttcatcacc cccaaccccc tgagcaagat ttcctgggtc   2400

aacaggttac atttggccaa aatcggactc cgggaggaga accagccagg ctggctatgc   2460

ccggatgagg acaagaagag caaagcccca ttctggtgcc cgatcctggc ctgctgcatc   2520

cctgccttct cctcccgggc actcagcctg cagcttgggg ccctggtcca cagtcctgtc   2580

aactgtcccc tgctgggttt ctcagcagtc agcacctccc ttccacaggg ctacctctgg   2640

gtcgggggcg gacaggaagg cgcagggggc caggtggaaa tcttttcctt gaaccggccc   2700

tcgccccgca ccgtcaagtc cttcccactg gcagcccctg tgctctgcat ggagtatatc   2760

ccggagctgg aggaggaggc ggagagcaga gacgagagcc cgacagttgc tgacccctcg   2820

gccacggtgc atccaaccat ctgcctcggg ctccaggatg gcagcatcct cctctacagc   2880

agtgtggaca ctggcaccca gtgcctggtg agctgcagga gcccaggtct gcagcctgtg   2940

ctctgcctgc gacacagccc cttccacctg ctcgctggcc tgcaggatgg gacccttgct   3000

gcttaccctc ggaccagcgg aggtgtcctg tgggacctgg agagccctcc cgtgtgcctg   3060

actgtggggc ccgggcctgt ccgcaccctg ttgagcctgg aggatgccgt gtgggccagc   3120

tgtgggcccc gggtcactgt cctggaagcc accaccctgc agcctcagca aagcttcgag   3180

gcgcaccagg acgaggcagt gagcgtgaca cacatggtga aggcgggcag cggcgtctgg   3240

atggccttct cctccggcac ctccatccgc ctcttccaca ctgagaccct ggagcatctg   3300

caagagatca acatcgccac caggaccacc ttcctcctgc caggccagaa gcacttgtgt   3360

gtcaccagcc tcctgatctg ccagggtctg ctctgggtgg gcactgacca gggtgtcatc   3420

gtcctgctgc ccgtgcctcg gctggaaggc atccccaaga tcacagggaa aggcatggtc   3480

tcactcaacg ggcactgtgg gcctgtggcc ttcctggctg tggctaccag catcctggcc   3540

cctgacatcc tgcggagtga ccaggaggag gctgaggggc cccgggctga ggaggacaag   3600

ccagacgggc aggcacacga gcccatgccc gatagccacg tgggccgaga gctgacccgc   3660

aagaagggca tcctcttgca gtaccgcctg cgctccaccg cacacctccc gggcccgctg   3720

ctctccatgc gggagccggc gcctgctgat ggcgcagctt tggagcacag cgaggaggac   3780

ggctccattt acgagatggc cgacgacccc gacatctggg tgcgcagccg gccctgcgcc   3840

cgcgacgccc accgcaagga gatttgctct gtggccatca tctccggcgg gcagggctac   3900

cgcaactttg gcagcgctct gggcagcagt gggaggcagg ccccgtgtgg ggagacggac   3960

agcaccctcc tcatctggca ggtgcccttg atgctatagc gcctcccctc tcccctcaga   4020

gggcacagct gcaggcctga ccaaggccac gcccggctct cgtgctctag gacctgcacg   4080

ggacttgtgg atgggcctgg actctccaga aactacttgg gcagagcaaa ggaaaacctc   4140

ttgttttaaa aaaatttttt tcagagtgtt ttggggagga gttttagggc ttggggagag   4200

ggaggacaca tctggaggaa atggccttct ttttaaaagc aaaaaacaca aaacctcaca   4260

actgcctggc aagcccagta tcacttgttt gggccctagc gggactccaa ggcagccaca   4320

cgcccctcct ggaagggtgt gtgcgtgtga gtgtgtgcga gtgtgtgggc tggtgtgtga   4380

atatctataa ataagtatat atggtgtata ttatatgtgt ataaataaag tctgtacata   4440

ttggagctct gggagatgct ggaataaaag acaagagtta catctggact tggaaaaaaa   4500

aa                                                                  4502


<210>  80
<211>  1279
<212>  PRT
<213>  Homosapiens

<400>  80

Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala Ile Gly Asp Gln Leu 
1               5                   10                  15      


Val Pro Gly Val Pro Gly Pro Ser Ser Glu Ala Glu Asp Asp Pro Gly 
            20                  25                  30          


Glu Ala Phe Glu Phe Asp Asp Ser Asp Asp Glu Glu Asp Thr Ser Ala 
        35                  40                  45              


Ala Leu Gly Val Pro Ser Leu Ala Pro Glu Arg Asp Thr Asp Pro Pro 
    50                  55                  60                  


Leu Ile His Leu Asp Ser Ile Pro Val Thr Asp Pro Asp Pro Ala Ala 
65                  70                  75                  80  


Ala Pro Pro Gly Thr Gly Val Pro Ala Trp Val Ser Asn Gly Asp Ala 
                85                  90                  95      


Ala Asp Ala Ala Phe Ser Gly Ala Arg His Ser Ser Trp Lys Arg Lys 
            100                 105                 110         


Ser Ser Arg Arg Ile Asp Arg Phe Thr Phe Pro Ala Leu Glu Glu Asp 
        115                 120                 125             


Val Ile Tyr Asp Asp Val Pro Cys Glu Ser Pro Asp Ala His Gln Pro 
    130                 135                 140                 


Gly Ala Glu Arg Asn Leu Leu Tyr Glu Asp Ala His Arg Ala Gly Ala 
145                 150                 155                 160 


Pro Arg Gln Ala Glu Asp Leu Gly Trp Ser Ser Ser Glu Phe Glu Ser 
                165                 170                 175     


Tyr Ser Glu Asp Ser Gly Glu Glu Ala Lys Pro Glu Val Glu Val Glu 
            180                 185                 190         


Pro Ala Lys His Arg Val Ser Phe Gln Pro Lys Leu Ser Pro Asp Leu 
        195                 200                 205             


Thr Arg Leu Lys Glu Arg Tyr Ala Arg Thr Lys Arg Asp Ile Leu Ala 
    210                 215                 220                 


Leu Arg Val Gly Gly Arg Asp Met Gln Glu Leu Lys His Lys Tyr Asp 
225                 230                 235                 240 


Cys Lys Met Thr Gln Leu Met Lys Ala Ala Lys Ser Gly Thr Lys Asp 
                245                 250                 255     


Gly Leu Glu Lys Thr Arg Met Ala Val Met Arg Lys Val Ser Phe Leu 
            260                 265                 270         


His Arg Lys Asp Val Leu Gly Asp Ser Glu Glu Glu Asp Met Gly Leu 
        275                 280                 285             


Leu Glu Val Ser Val Ser Asp Ile Lys Pro Pro Ala Pro Glu Leu Gly 
    290                 295                 300                 


Pro Met Pro Glu Gly Leu Ser Pro Gln Gln Val Val Arg Arg His Ile 
305                 310                 315                 320 


Leu Gly Ser Ile Val Gln Ser Glu Gly Ser Tyr Val Glu Ser Leu Lys 
                325                 330                 335     


Arg Ile Leu Gln Asp Tyr Arg Asn Pro Leu Met Glu Met Glu Pro Lys 
            340                 345                 350         


Ala Leu Ser Ala Arg Lys Cys Gln Val Val Phe Phe Arg Val Lys Glu 
        355                 360                 365             


Ile Leu His Cys His Ser Met Phe Gln Ile Ala Leu Ser Ser Arg Val 
    370                 375                 380                 


Ala Glu Trp Asp Ser Thr Glu Lys Ile Gly Asp Leu Phe Val Ala Ser 
385                 390                 395                 400 


Phe Ser Lys Ser Met Val Leu Asp Val Tyr Ser Asp Tyr Val Asn Asn 
                405                 410                 415     


Phe Thr Ser Ala Met Ser Ile Ile Lys Lys Ala Cys Leu Thr Lys Pro 
            420                 425                 430         


Ala Phe Leu Glu Phe Leu Lys Arg Arg Gln Val Cys Ser Pro Asp Arg 
        435                 440                 445             


Val Thr Leu Tyr Gly Leu Met Val Lys Pro Ile Gln Arg Phe Pro Gln 
    450                 455                 460                 


Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn Thr Pro Arg Gly His 
465                 470                 475                 480 


Pro Asp Arg Leu Ser Leu Gln Leu Ala Leu Thr Glu Leu Glu Thr Leu 
                485                 490                 495     


Ala Glu Lys Leu Asn Glu Gln Lys Arg Leu Ala Asp Gln Val Ala Glu 
            500                 505                 510         


Ile Gln Gln Leu Thr Lys Ser Val Ser Asp Arg Ser Ser Leu Asn Lys 
        515                 520                 525             


Leu Leu Thr Ser Gly Gln Arg Gln Leu Leu Leu Cys Glu Thr Leu Thr 
    530                 535                 540                 


Glu Thr Val Tyr Gly Asp Arg Gly Gln Leu Ile Lys Ser Lys Glu Arg 
545                 550                 555                 560 


Arg Val Phe Leu Leu Asn Asp Met Leu Val Cys Ala Asn Ile Asn Phe 
                565                 570                 575     


Lys Pro Ala Asn His Arg Gly Gln Leu Glu Ile Ser Ser Leu Val Pro 
            580                 585                 590         


Leu Gly Pro Lys Tyr Val Val Lys Trp Asn Thr Ala Leu Pro Gln Val 
        595                 600                 605             


Gln Val Val Glu Val Gly Gln Asp Gly Gly Thr Tyr Asp Lys Asp Asn 
    610                 615                 620                 


Val Leu Ile Gln His Ser Gly Ala Lys Lys Ala Ser Ala Ser Gly Gln 
625                 630                 635                 640 


Ala Gln Asn Lys Val Tyr Leu Gly Pro Pro Arg Leu Phe Gln Glu Leu 
                645                 650                 655     


Gln Asp Leu Gln Lys Asp Leu Ala Val Val Glu Gln Ile Thr Leu Leu 
            660                 665                 670         


Ile Ser Thr Leu His Gly Thr Tyr Gln Asn Leu Asn Met Thr Val Ala 
        675                 680                 685             


Gln Asp Trp Cys Leu Ala Leu Gln Arg Leu Met Arg Val Lys Glu Glu 
    690                 695                 700                 


Glu Ile His Ser Ala Asn Lys Cys Arg Leu Arg Leu Leu Leu Pro Gly 
705                 710                 715                 720 


Lys Pro Asp Lys Ser Gly Arg Pro Ile Ser Phe Met Val Val Phe Ile 
                725                 730                 735     


Thr Pro Asn Pro Leu Ser Lys Ile Ser Trp Val Asn Arg Leu His Leu 
            740                 745                 750         


Ala Lys Ile Gly Leu Arg Glu Glu Asn Gln Pro Gly Trp Leu Cys Pro 
        755                 760                 765             


Asp Glu Asp Lys Lys Ser Lys Ala Pro Phe Trp Cys Pro Ile Leu Ala 
    770                 775                 780                 


Cys Cys Ile Pro Ala Phe Ser Ser Arg Ala Leu Ser Leu Gln Leu Gly 
785                 790                 795                 800 


Ala Leu Val His Ser Pro Val Asn Cys Pro Leu Leu Gly Phe Ser Ala 
                805                 810                 815     


Val Ser Thr Ser Leu Pro Gln Gly Tyr Leu Trp Val Gly Gly Gly Gln 
            820                 825                 830         


Glu Gly Ala Gly Gly Gln Val Glu Ile Phe Ser Leu Asn Arg Pro Ser 
        835                 840                 845             


Pro Arg Thr Val Lys Ser Phe Pro Leu Ala Ala Pro Val Leu Cys Met 
    850                 855                 860                 


Glu Tyr Ile Pro Glu Leu Glu Glu Glu Ala Glu Ser Arg Asp Glu Ser 
865                 870                 875                 880 


Pro Thr Val Ala Asp Pro Ser Ala Thr Val His Pro Thr Ile Cys Leu 
                885                 890                 895     


Gly Leu Gln Asp Gly Ser Ile Leu Leu Tyr Ser Ser Val Asp Thr Gly 
            900                 905                 910         


Thr Gln Cys Leu Val Ser Cys Arg Ser Pro Gly Leu Gln Pro Val Leu 
        915                 920                 925             


Cys Leu Arg His Ser Pro Phe His Leu Leu Ala Gly Leu Gln Asp Gly 
    930                 935                 940                 


Thr Leu Ala Ala Tyr Pro Arg Thr Ser Gly Gly Val Leu Trp Asp Leu 
945                 950                 955                 960 


Glu Ser Pro Pro Val Cys Leu Thr Val Gly Pro Gly Pro Val Arg Thr 
                965                 970                 975     


Leu Leu Ser Leu Glu Asp Ala Val Trp Ala Ser Cys Gly Pro Arg Val 
            980                 985                 990         


Thr Val Leu Glu Ala Thr Thr Leu  Gln Pro Gln Gln Ser  Phe Glu Ala 
        995                 1000                 1005             


His Gln  Asp Glu Ala Val Ser  Val Thr His Met Val  Lys Ala Gly 
    1010                 1015                 1020             


Ser Gly  Val Trp Met Ala Phe  Ser Ser Gly Thr Ser  Ile Arg Leu 
    1025                 1030                 1035             


Phe His  Thr Glu Thr Leu Glu  His Leu Gln Glu Ile  Asn Ile Ala 
    1040                 1045                 1050             


Thr Arg  Thr Thr Phe Leu Leu  Pro Gly Gln Lys His  Leu Cys Val 
    1055                 1060                 1065             


Thr Ser  Leu Leu Ile Cys Gln  Gly Leu Leu Trp Val  Gly Thr Asp 
    1070                 1075                 1080             


Gln Gly  Val Ile Val Leu Leu  Pro Val Pro Arg Leu  Glu Gly Ile 
    1085                 1090                 1095             


Pro Lys  Ile Thr Gly Lys Gly  Met Val Ser Leu Asn  Gly His Cys 
    1100                 1105                 1110             


Gly Pro  Val Ala Phe Leu Ala  Val Ala Thr Ser Ile  Leu Ala Pro 
    1115                 1120                 1125             


Asp Ile  Leu Arg Ser Asp Gln  Glu Glu Ala Glu Gly  Pro Arg Ala 
    1130                 1135                 1140             


Glu Glu  Asp Lys Pro Asp Gly  Gln Ala His Glu Pro  Met Pro Asp 
    1145                 1150                 1155             


Ser His  Val Gly Arg Glu Leu  Thr Arg Lys Lys Gly  Ile Leu Leu 
    1160                 1165                 1170             


Gln Tyr  Arg Leu Arg Ser Thr  Ala His Leu Pro Gly  Pro Leu Leu 
    1175                 1180                 1185             


Ser Met  Arg Glu Pro Ala Pro  Ala Asp Gly Ala Ala  Leu Glu His 
    1190                 1195                 1200             


Ser Glu  Glu Asp Gly Ser Ile  Tyr Glu Met Ala Asp  Asp Pro Asp 
    1205                 1210                 1215             


Ile Trp  Val Arg Ser Arg Pro  Cys Ala Arg Asp Ala  His Arg Lys 
    1220                 1225                 1230             


Glu Ile  Cys Ser Val Ala Ile  Ile Ser Gly Gly Gln  Gly Tyr Arg 
    1235                 1240                 1245             


Asn Phe  Gly Ser Ala Leu Gly  Ser Ser Gly Arg Gln  Ala Pro Cys 
    1250                 1255                 1260             


Gly Glu  Thr Asp Ser Thr Leu  Leu Ile Trp Gln Val  Pro Leu Met 
    1265                 1270                 1275             


Leu 
    


<210>  81
<211>  2547
<212>  DNA
<213>  Homosapiens

<400>  81
ccacgcgtcc gcggacgcgt gggcgagaag tgcttccaag cgtccatttt gagccttgga     60

aactacgacg accaaagggc cacgggttcc tgggtcgttt ctcatttccg tcgagttaaa    120

cgtctggggc tgcttctgag gaatcagctt ggctggccag caagttcagc tccggcaagt    180

catttgattc acccggtgat gaaatggggg tcaaccagtc tgtgggcttt ccacctgtca    240

caggacccca cctcgtaggc tgtggggatg tgatggaggg tcagaatctc caggggagct    300

tctttcgact cttctacccc tgccaaaagg cagaggagac catggagcag cccctgtgga    360

ttccccgcta tgagtactgc actggcctgg ccgagtacct gcagtttaat aagcgctgcg    420

ggggcttgct gttcaacctg gcggtgggat cttgtcgcct gcctgttagc tggaatggcc    480

cctttaagac aaaggactct ggatacccct tgatcatctt ctcccatggc ctaggagcct    540

tcaggacttt gtattcagcc ttctgcatgg agctggcctc acgtggcttt gtggttgctg    600

tgccagagca cagggaccgg tcagcggcaa ccacctattt ctgcaagcag gccccagaag    660

agaaccagcc caccaatgaa tcgctgcagg aggaatggat ccctttccgt cgagttgagg    720

aaggggagaa ggaatttcat gttcggaatc cccaggtgca tcagcgggta agcgagtgtt    780

tacgggtgtt gaagatcctg caagaggtca ctgctgggca gactgtcttc aacatcttgc    840

ctggtggctt ggatctgatg actttgaagg gcaacattga catgagccgt gtggctgtga    900

tgggacattc atttggaggg gccacagcta ttctggcttt ggccaaggag acccaatttc    960

ggtgtgcggt ggctctggat gcttggatgt ttcctctgga acgtgacttt taccccaagg   1020

cccgaggacc tgtgttcttt atcaatactg agaaattcca gacaatggag agtgtcaatt   1080

tgatgaagaa gatatgtgcc cagcatgaac agtctaggat cataaccgtt cttggttctg   1140

ttcatcggag tcaaactgac tttgcttttg tgactggcaa cttgattggt aaattcttct   1200

ccactgaaac ccgtgggagc ctggacccct atgaagggca ggaggttatg gtacgggcca   1260

tgttggcctt cctgcagaag cacctcgacc tgaaagaaga ctataatcaa tggaacaacc   1320

ttattgaagg cattggaccg tcgctcaccc caggggcccc ccaccatctg tccagcctgt   1380

aggcacaact ggccatttgt aaagtcactt cagccaagtt ttcatttggg agctacccaa   1440

gggcacccat gagctcctat caagaagtga tcaacgtgac cccttttcac agattgaaag   1500

gtgtaatcac actgctgctt ggataactgg gtactttgat cttagatttg atcttaaaat   1560

cactttggga ctgggatccc ttgctgattg acaaacagac tttctgggac cttgatggag   1620

tggggaacaa gcagtagagt gggactgggg gagacccagg ccccgggctg agcactgtga   1680

ggcctggatg tgaagactca gcccagcgaa gctcattccc ttacccccgg ccagtgctgc   1740

tgcttcagtg gaagagatga agccaaagga cagaatgaaa atccctacct tcagagactc   1800

tagcccagcc caacaccatc tcttcctacc tctcagcctt ctccctcccc agggccactt   1860

gttgaagtct gagcacttta tgtaaatttc taggtgtgag ccgtgatcac attttctatt   1920

tatttccaag tcttctcatt gtatggaaca tagtactact tatacttaca gtagtaagtt   1980

atacttgtga gcccacagag tggcagacag catggctctc acagcacagg gagaaaaact   2040

gaggtacaca gaggtacctc agaagctctg gatgtctttg ggggttttgc taagtgtatc   2100

ttgataggaa acaacaaaag caggttgaga tggggaagat gacagaacaa cagtgttaaa   2160

tggccatttg cacaggcctt tgccacaaca gagaagtagt ttggtcagct aaaactcagc   2220

tgcagcctgg acagtagagc gagaccccat cttaaaaata aagaaggctg ggcgtggtgg   2280

ctcatgcctg taatcccagc actttgggag gccaaggcag gcagatcact taaggccagg   2340

agttcaagac cacctggcca acatggtgaa accccgtctc tactaaaaat acaaaaaatt   2400

agcctggcgt aatggcaggc gcctataatc ccagctactc aggaggctga agcagaagaa   2460

tcacttgaac ctaggaggcg gaggttgcag tgagtcaaga tcgcgccact gcactccagc   2520

ctgggtgaca gagcaagact ctgtctt                                       2547


<210>  82
<211>  392
<212>  PRT
<213>  Homosapiens

<400>  82

Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His 
1               5                   10                  15      


Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser 
            20                  25                  30          


Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu 
        35                  40                  45              


Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu 
    50                  55                  60                  


Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala 
65                  70                  75                  80  


Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr 
                85                  90                  95      


Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala 
            100                 105                 110         


Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly 
        115                 120                 125             


Phe Val Val Ala Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr 
    130                 135                 140                 


Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro Thr Asn Glu Ser 
145                 150                 155                 160 


Leu Gln Glu Glu Trp Ile Pro Phe Arg Arg Val Glu Glu Gly Glu Lys 
                165                 170                 175     


Glu Phe His Val Arg Asn Pro Gln Val His Gln Arg Val Ser Glu Cys 
            180                 185                 190         


Leu Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala Gly Gln Thr Val 
        195                 200                 205             


Phe Asn Ile Leu Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Asn 
    210                 215                 220                 


Ile Asp Met Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala 
225                 230                 235                 240 


Thr Ala Ile Leu Ala Leu Ala Lys Glu Thr Gln Phe Arg Cys Ala Val 
                245                 250                 255     


Ala Leu Asp Ala Trp Met Phe Pro Leu Glu Arg Asp Phe Tyr Pro Lys 
            260                 265                 270         


Ala Arg Gly Pro Val Phe Phe Ile Asn Thr Glu Lys Phe Gln Thr Met 
        275                 280                 285             


Glu Ser Val Asn Leu Met Lys Lys Ile Cys Ala Gln His Glu Gln Ser 
    290                 295                 300                 


Arg Ile Ile Thr Val Leu Gly Ser Val His Arg Ser Gln Thr Asp Phe 
305                 310                 315                 320 


Ala Phe Val Thr Gly Asn Leu Ile Gly Lys Phe Phe Ser Thr Glu Thr 
                325                 330                 335     


Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Val Met Val Arg Ala 
            340                 345                 350         


Met Leu Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asn 
        355                 360                 365             


Gln Trp Asn Asn Leu Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly 
    370                 375                 380                 


Ala Pro His His Leu Ser Ser Leu 
385                 390         


<210>  83
<211>  4009
<212>  DNA
<213>  Homosapiens

<400>  83
ccgactggaa agggatggga gtgataccat agggtttggg gggcttggca caacggccct     60

ggcctctgca ctgtgatagc tccaagccaa atggtgcaag gcagctgctg ggctgcgggg    120

aagaggggct gcacttcctg agctggtgca gcggcagagt ggataaggat caggaccccg    180

agccctcctg gccctccaag gcggggggac accggctgca cccaggctgt gacctcagct    240

gacgccgatg atccacatgg gatgcagggt ctaattttag ctccagccac aggggccaca    300

gcccagaagc gtctgccagc gggcacaggg gcagccaggg ctgctcaggc aaggggagga    360

gtgggaagac cagcccagct ccctccagcc tgtccctggc caagccgcct cctgtgggag    420

ctctgactgg tccccatggc ctggcagaca gccctcctct cagttgaggg caaggtcaag    480

gggtgcagcc aggagggcag ggggacacgg ccctgcattc tggacagggg ttgcgtcagc    540

cagagcagtg cccaggggca ggggtccctg ctgggaggga aaaggctggc ttggttgtcc    600

aaaggccgag aaggcagagt cctgagagca ggggggccag gccagcaagc tgggtcccac    660

ctggcctcct cctgcctggc tggtgactca ctatctgacc ttagacaggc ggcctggtct    720

cgatgggcct cagtcttccc atctgtacaa tgacagcaca ggactagcag gtcggtccca    780

gctctggtct cccgccccag gccctgctct tcctgcttgc tggcagaggc ctcccagctt    840

ccctagccct gactgtgggt ggccacatgc agtcgtggag gagaagaaag tccctgtggc    900

tggcactgtc agcctcctgg ctcctgcttg tcctgctggg aggcttctcc cttctccgcc    960

tggcgttgcc tcccagacct cggcccgggg cttcccaagg ctggccccgc tggctggatg   1020

cagagctcct gcagagcttc tcccagcctg gagagctccc agaagatgcc gtttcacctc   1080

ctcaagcccc tcatggtggc agctgcaact gggaatcttg ctttgatacc tcaaagtgca   1140

ggggcgatgg ccttaaggta ttcgtgtacc cagcggttgg aaccatctct gagactcatc   1200

gcaggatcct ggcttccatt gagggctctc gcttctacac attcagccct gctggggcct   1260

gcctcctcct cctcctcagc ctggacgccc agactggaga gtgcagctca atgcctctgc   1320

aatggaacag gggcaggaac catctggtcc tccgtctcca cccggctccc tgccccagga   1380

ccttccagct gggacaggct atggtggctg aggccagccc cacggtggac tccttccggc   1440

ccggctttga tgtggccctc ccttttctcc ctgaagccca cccgttgcga ggtggggctc   1500

ctggccagct gcggcaacac agcccccagc ccggggtagc cctgctagcc ctggaagagg   1560

agaggggtgg gtggcgcaca gcagacactg gctcctctgc ctgcccctgg gatgggcgct   1620

gtgagcaaga ccctggacct gggcagaccc agcgccagga gacgctgccc aatgccacct   1680

tctgcctcat ctctggccac cgtcccgagg ctgcctcgcg cttcctccaa gccctgcagg   1740

ccggctgcat cccagtgctt ctcagccccc gctgggagct gcccttctcc gaggtcatcg   1800

actggaccaa ggcagccatc gtagctgatg agaggctccc acttcaggtc ctggctgccc   1860

tccaggagat gtcccctgca cgggtcctcg ccctgcgtca gcagacccag tttctatggg   1920

atgcctactt ctcctcagtg gagaaggtca tccataccac tctggaggtt attcaggacc   1980

ggatttttgg aacatcagct aacccctcac tgctgtggaa cagcccccca ggggcactcc   2040

tggccctgtc tactttttcc acaagccccc aggacttccc cttctactac ctgcaacagg   2100

gctcccgccc tgagggcaga ttcagcgccc tgatctgggt ggggccccca ggccagcccc   2160

ctctgaagct catccaggcg gtggcaggct cccagcactg tgcccagatc ttggttctct   2220

ggagcaatga gaggccactc ccatccaggt ggccggagac agctgtgccc ttgacagtca   2280

ttgatgggca caggaaggtt agtgatcgct tctacccata tagcaccatc agaacagatg   2340

ccatcctcag cctcgatgcc cgcagcagtc tttccacaag tgaggtggac tttgcctttc   2400

tggtgtggca gagcttccca gagcggatgg tgggcttcct gacgtcgagc catttctggg   2460

acgaggccca tggtggctgg ggctacactg ctgagaggac caacgaattc tccatggttc   2520

tcaccacagc cgccttctac cataggtatt accacactct cttcacccac tccctgccca   2580

aggctctgag gaccctggca gatgaggcac ccacctgtgt ggacgtcctg atgaatttca   2640

tagtagcagc agtcaccaag ctgcccccta tcaaggtgcc ctatggcaag cagcgccagg   2700

aggctgctcc actggcgcct gggggcccgg ggcccaggcc aaagccgcct gccccagccc   2760

ccgactgcat caaccagata gcggcagcgt tcggccacat gcccttgctg tcctctcgtc   2820

tgcgtctgga cccggtgctg tttaaggacc cggtgtccgt gcagcgcaag aagtaccgca   2880

gcctggagaa gccctagggg ggcgacccgc ggagacccca tcaaaggtct cagcccagct   2940

cccagggggc ccggcgcctg ccggcgggct ccgctcttgg gacaccggta aaacctatca   3000

tgtcagccag cgggcccaca cgtcggaccc cggttggcca atcacaacag gggggcgtgg   3060

ccttaccttc tcctgctcgc cctcagccgc ggagcctctg cggaggctga gccccgcgac   3120

cggagcgccg ctctccgctt ctccacccag ctaacttctg ctcgtctttc agagcattgt   3180

ctcctccagg gacttgcctg gccctcctcc ccctccgccc ccaatgggtt cggtctcctt   3240

tgcgctttcg cagcccagtg tttgccgcgg ttcccgcacg gtcaggcccc aggactggct   3300

tgcgagcccc ggggggcggg tcgtgtcgtg tccttttctc tctggctagg caggtgtgcc   3360

gcaaatattt gacgaataga tggatggcag acattaactg cgtgcctggc cctatgaggg   3420

cggcggcggg acagggtgag cggagagaca gaactgtccc cgccccaccc cgccacccat   3480

tcctagggtt cctagtcccg ggaaggcaac tacccaaaga cgcctgggtt gtcaggctca   3540

atccttgagc ctcaaccaag gagcagaggg gtgcgggtaa acgaggagtg gggcgaggaa   3600

agcgggatgg gaacaagtgg cctgtccccg cacggcccgc ggctcagcct cggccgtctg   3660

ccctgcacta ccaaggccga ccactagagg tcagcgtcgc gccgcactct tcacccgcat   3720

gcccagaggg cggccgggat gtggagggtg aacgctgtgg gcagctcggg ggctgaaagc   3780

tgggaagaga aatctgaaga acagccccat ctctttcgcc tgcacacttg gaactcagca   3840

agaagggact gtttctaggt gggctgggcg cgagcaggga ctgtcccgag ctggtatagg   3900

tgagaatgga gttggggggg gacactaggt ctccggggtt cacccacctg gagctggaat   3960

tatcacttcc gaaataaagc gcgtgtcctt gcaaaaaaaa aaaaaaaaa               4009


<210>  84
<211>  676
<212>  PRT
<213>  Homosapiens

<400>  84

Met Gln Ser Trp Arg Arg Arg Lys Ser Leu Trp Leu Ala Leu Ser Ala 
1               5                   10                  15      


Ser Trp Leu Leu Leu Val Leu Leu Gly Gly Phe Ser Leu Leu Arg Leu 
            20                  25                  30          


Ala Leu Pro Pro Arg Pro Arg Pro Gly Ala Ser Gln Gly Trp Pro Arg 
        35                  40                  45              


Trp Leu Asp Ala Glu Leu Leu Gln Ser Phe Ser Gln Pro Gly Glu Leu 
    50                  55                  60                  


Pro Glu Asp Ala Val Ser Pro Pro Gln Ala Pro His Gly Gly Ser Cys 
65                  70                  75                  80  


Asn Trp Glu Ser Cys Phe Asp Thr Ser Lys Cys Arg Gly Asp Gly Leu 
                85                  90                  95      


Lys Val Phe Val Tyr Pro Ala Val Gly Thr Ile Ser Glu Thr His Arg 
            100                 105                 110         


Arg Ile Leu Ala Ser Ile Glu Gly Ser Arg Phe Tyr Thr Phe Ser Pro 
        115                 120                 125             


Ala Gly Ala Cys Leu Leu Leu Leu Leu Ser Leu Asp Ala Gln Thr Gly 
    130                 135                 140                 


Glu Cys Ser Ser Met Pro Leu Gln Trp Asn Arg Gly Arg Asn His Leu 
145                 150                 155                 160 


Val Leu Arg Leu His Pro Ala Pro Cys Pro Arg Thr Phe Gln Leu Gly 
                165                 170                 175     


Gln Ala Met Val Ala Glu Ala Ser Pro Thr Val Asp Ser Phe Arg Pro 
            180                 185                 190         


Gly Phe Asp Val Ala Leu Pro Phe Leu Pro Glu Ala His Pro Leu Arg 
        195                 200                 205             


Gly Gly Ala Pro Gly Gln Leu Arg Gln His Ser Pro Gln Pro Gly Val 
    210                 215                 220                 


Ala Leu Leu Ala Leu Glu Glu Glu Arg Gly Gly Trp Arg Thr Ala Asp 
225                 230                 235                 240 


Thr Gly Ser Ser Ala Cys Pro Trp Asp Gly Arg Cys Glu Gln Asp Pro 
                245                 250                 255     


Gly Pro Gly Gln Thr Gln Arg Gln Glu Thr Leu Pro Asn Ala Thr Phe 
            260                 265                 270         


Cys Leu Ile Ser Gly His Arg Pro Glu Ala Ala Ser Arg Phe Leu Gln 
        275                 280                 285             


Ala Leu Gln Ala Gly Cys Ile Pro Val Leu Leu Ser Pro Arg Trp Glu 
    290                 295                 300                 


Leu Pro Phe Ser Glu Val Ile Asp Trp Thr Lys Ala Ala Ile Val Ala 
305                 310                 315                 320 


Asp Glu Arg Leu Pro Leu Gln Val Leu Ala Ala Leu Gln Glu Met Ser 
                325                 330                 335     


Pro Ala Arg Val Leu Ala Leu Arg Gln Gln Thr Gln Phe Leu Trp Asp 
            340                 345                 350         


Ala Tyr Phe Ser Ser Val Glu Lys Val Ile His Thr Thr Leu Glu Val 
        355                 360                 365             


Ile Gln Asp Arg Ile Phe Gly Thr Ser Ala Asn Pro Ser Leu Leu Trp 
    370                 375                 380                 


Asn Ser Pro Pro Gly Ala Leu Leu Ala Leu Ser Thr Phe Ser Thr Ser 
385                 390                 395                 400 


Pro Gln Asp Phe Pro Phe Tyr Tyr Leu Gln Gln Gly Ser Arg Pro Glu 
                405                 410                 415     


Gly Arg Phe Ser Ala Leu Ile Trp Val Gly Pro Pro Gly Gln Pro Pro 
            420                 425                 430         


Leu Lys Leu Ile Gln Ala Val Ala Gly Ser Gln His Cys Ala Gln Ile 
        435                 440                 445             


Leu Val Leu Trp Ser Asn Glu Arg Pro Leu Pro Ser Arg Trp Pro Glu 
    450                 455                 460                 


Thr Ala Val Pro Leu Thr Val Ile Asp Gly His Arg Lys Val Ser Asp 
465                 470                 475                 480 


Arg Phe Tyr Pro Tyr Ser Thr Ile Arg Thr Asp Ala Ile Leu Ser Leu 
                485                 490                 495     


Asp Ala Arg Ser Ser Leu Ser Thr Ser Glu Val Asp Phe Ala Phe Leu 
            500                 505                 510         


Val Trp Gln Ser Phe Pro Glu Arg Met Val Gly Phe Leu Thr Ser Ser 
        515                 520                 525             


His Phe Trp Asp Glu Ala His Gly Gly Trp Gly Tyr Thr Ala Glu Arg 
    530                 535                 540                 


Thr Asn Glu Phe Ser Met Val Leu Thr Thr Ala Ala Phe Tyr His Arg 
545                 550                 555                 560 


Tyr Tyr His Thr Leu Phe Thr His Ser Leu Pro Lys Ala Leu Arg Thr 
                565                 570                 575     


Leu Ala Asp Glu Ala Pro Thr Cys Val Asp Val Leu Met Asn Phe Ile 
            580                 585                 590         


Val Ala Ala Val Thr Lys Leu Pro Pro Ile Lys Val Pro Tyr Gly Lys 
        595                 600                 605             


Gln Arg Gln Glu Ala Ala Pro Leu Ala Pro Gly Gly Pro Gly Pro Arg 
    610                 615                 620                 


Pro Lys Pro Pro Ala Pro Ala Pro Asp Cys Ile Asn Gln Ile Ala Ala 
625                 630                 635                 640 


Ala Phe Gly His Met Pro Leu Leu Ser Ser Arg Leu Arg Leu Asp Pro 
                645                 650                 655     


Val Leu Phe Lys Asp Pro Val Ser Val Gln Arg Lys Lys Tyr Arg Ser 
            660                 665                 670         


Leu Glu Lys Pro 
        675     


<210>  85
<211>  2473
<212>  DNA
<213>  Homosapiens

<400>  85
gagacacggg agcgcttggc acgcggagcc agagccggag ctgcagccgc agcgggagcc     60

gggggagctc aggggccgca ggagccgggc cggagtgagc gcacctcgcg gggccctcgg    120

ggcaggtggg tgagcgccac ccggagtccc gcgcgcaact ttcagggcgc actcggcggg    180

gcggctgcgc ggctgccggg actcggcgcg ggactgcatg gaggccaagg agaagcagca    240

tctgttggac gccaggccgg caatccggtc atacacggga tctctgtggc aggaaggggc    300

tggctggatt cctctgcccc gacctggcct ggacttgcag gccattgagc tggctgccca    360

gagcaaccat cactgccatg ctcagaaggg tcctgacagt cactgtgacc ccaagaaggg    420

gaaggcccag cgccagctgt atgtagcctc tgccatctgc ctgttgttca tgatcggaga    480

agtcgttggt gggtacctgg cacacagctt ggctgtcatg actgacgcag cacacctgct    540

cactgacttt gccagcatgc tcatcagcct cttctccctc tggatgtcct cccggccagc    600

caccaagacc atgaactttg gctggcagag agctgagatc ttgggagccc tggtctctgt    660

actgtccatc tgggtcgtga cgggggtact ggtgtacctg gctgtggagc ggctgatctc    720

tggggactat gaaattgacg gggggaccat gctgatcacg tcgggctgcg ctgtggctgt    780

gaacatcata atggggttga cccttcacca gtctggccat gggcacagcc acggcaccac    840

caaccagcag gaggagaacc ccagcgtccg agctgccttc atccatgtga tcggcgactt    900

tatgcagagc atgggtgtcc tagtggcagc ctatatttta tacttcaagc cagaatacaa    960

gtatgtagac cccatctgca ccttcgtctt ctccatcctg gtcctgggga caaccttgac   1020

catcctgaga gatgtgatcc tggtgttgat ggaagggacc cccaagggcg ttgacttcac   1080

agctgttcgt gatctgctgc tgtcggtgga gggggtagaa gccctgcaca gcctgcatat   1140

ctgggcactg acggtggccc agcctgttct gtctgtccac atcgccattg ctcagaatac   1200

agacgcccag gctgtgctga agacagccag cagccgcctc caagggaagt tccacttcca   1260

caccgtgacc atccagatcg aggactactc ggaggacatg aaggactgtc aggcatgcca   1320

gggcccctca gactgactgc tcagccaggc accaactggg gcatgaacag gacctgcagg   1380

tggctggact gagtgtcccc caggcccagc caggactttg cctaccccag ctgtgttgta   1440

aaccaggtcc ccctcctgac ctctgcccca ctccaggaat ggagctcttc ccagcctccc   1500

atctgactac agccagggtg gggactcagc gggtataaag ctagtgtgac cctgctcttc   1560

cagctcctgg gccagctctg gaagggctgt atttgggcct aatcctcagc aactgttcta   1620

ccactcgcag gggcaaaggt ggtgagccac gggacgtcca aggggaggct ggccccagcg   1680

cgcccatact gcctgcctca tgccccattc tcagcctggc tggcctttgc ctttatgaat   1740

ctgagcccct ccatctgcct atagcaatag gcacgggggt gaggaccctc acactctcat   1800

ttgagcctcc ctgaggcagg gagccaggag gcacctgagg cctatctgtg ccttagtcac   1860

ttcagctatg agccaaatgt tccctttcct ggaggggaga ggcttcttac taggtaagag   1920

acaggtttcc tctttcctta tttcctcagc tgtgccaaca caaaaaacaa ctttggcaca   1980

ggtggtgggc agggggtaga gagatttcag cttgggttct gcactaacag cctccaagcc   2040

ccctggcact tctgttgccc tgagagtgtc ccaggggatt cagagtctcc agaaagatat   2100

ggctgggcca actctgttgc ctacctggcc tgacccagtc ggagcctgac atggtggagg   2160

gaaagggaga caagtggggc tgcactcggt ccagaggcca gctaggaggg aaaccgcagc   2220

ttcctggggc ttgtgtgtga agattcctga cttaggggtg gcttttgttt acaagatgca   2280

agaggggaaa cctgtccccg actcatcgag acaacatgcc cagttatcag ggagtcctgt   2340

gtcacaaggt ctgtctctgc cattgtaagc aagtgccttg ggcgagctgg cctctgcccc   2400

acagtctcat ctgtacaccg acagggttga tgcctccctc acagggttga gaacaagagc   2460

cagttggcca agt                                                      2473


<210>  86
<211>  372
<212>  PRT
<213>  Homosapiens

<400>  86

Met Glu Ala Lys Glu Lys Gln His Leu Leu Asp Ala Arg Pro Ala Ile 
1               5                   10                  15      


Arg Ser Tyr Thr Gly Ser Leu Trp Gln Glu Gly Ala Gly Trp Ile Pro 
            20                  25                  30          


Leu Pro Arg Pro Gly Leu Asp Leu Gln Ala Ile Glu Leu Ala Ala Gln 
        35                  40                  45              


Ser Asn His His Cys His Ala Gln Lys Gly Pro Asp Ser His Cys Asp 
    50                  55                  60                  


Pro Lys Lys Gly Lys Ala Gln Arg Gln Leu Tyr Val Ala Ser Ala Ile 
65                  70                  75                  80  


Cys Leu Leu Phe Met Ile Gly Glu Val Val Gly Gly Tyr Leu Ala His 
                85                  90                  95      


Ser Leu Ala Val Met Thr Asp Ala Ala His Leu Leu Thr Asp Phe Ala 
            100                 105                 110         


Ser Met Leu Ile Ser Leu Phe Ser Leu Trp Met Ser Ser Arg Pro Ala 
        115                 120                 125             


Thr Lys Thr Met Asn Phe Gly Trp Gln Arg Ala Glu Ile Leu Gly Ala 
    130                 135                 140                 


Leu Val Ser Val Leu Ser Ile Trp Val Val Thr Gly Val Leu Val Tyr 
145                 150                 155                 160 


Leu Ala Val Glu Arg Leu Ile Ser Gly Asp Tyr Glu Ile Asp Gly Gly 
                165                 170                 175     


Thr Met Leu Ile Thr Ser Gly Cys Ala Val Ala Val Asn Ile Ile Met 
            180                 185                 190         


Gly Leu Thr Leu His Gln Ser Gly His Gly His Ser His Gly Thr Thr 
        195                 200                 205             


Asn Gln Gln Glu Glu Asn Pro Ser Val Arg Ala Ala Phe Ile His Val 
    210                 215                 220                 


Ile Gly Asp Phe Met Gln Ser Met Gly Val Leu Val Ala Ala Tyr Ile 
225                 230                 235                 240 


Leu Tyr Phe Lys Pro Glu Tyr Lys Tyr Val Asp Pro Ile Cys Thr Phe 
                245                 250                 255     


Val Phe Ser Ile Leu Val Leu Gly Thr Thr Leu Thr Ile Leu Arg Asp 
            260                 265                 270         


Val Ile Leu Val Leu Met Glu Gly Thr Pro Lys Gly Val Asp Phe Thr 
        275                 280                 285             


Ala Val Arg Asp Leu Leu Leu Ser Val Glu Gly Val Glu Ala Leu His 
    290                 295                 300                 


Ser Leu His Ile Trp Ala Leu Thr Val Ala Gln Pro Val Leu Ser Val 
305                 310                 315                 320 


His Ile Ala Ile Ala Gln Asn Thr Asp Ala Gln Ala Val Leu Lys Thr 
                325                 330                 335     


Ala Ser Ser Arg Leu Gln Gly Lys Phe His Phe His Thr Val Thr Ile 
            340                 345                 350         


Gln Ile Glu Asp Tyr Ser Glu Asp Met Lys Asp Cys Gln Ala Cys Gln 
        355                 360                 365             


Gly Pro Ser Asp 
    370         


<210>  87
<211>  2326
<212>  DNA
<213>  Homosapiens

<400>  87
gagacacggg agcgcttggc acgcggagcc agagccggag ctgcagccgc agcgggagcc     60

gggggagctc aggggccgca ggagccgggc cggagtgagc gcacctcgcg gggccctcgg    120

ggcaggtggg tgagcgccac ccggagtccc gcgcgcaact ttcagggcgc actcggcggg    180

gcggctgcgc ggctgccggg actcggcgcg ggactgcatg gaggccaagg agaagcagca    240

tctgttggac gccaggccgg caatccggtc atacacggga tctctgtggc aggaaggggc    300

tggctggatt cctctgcccc gacctggcct ggacttgcag gccattgagc tggctgccca    360

gagcaaccat cactgccatg ctcagaaggg tcctgacagt cactgtgacc ccaagaaggg    420

gaaggcccag cgccagctgt atgtagcctc tgccatctgc ctgttgttca tgatcggaga    480

agtcgttgag atcttgggag ccctggtctc tgtactgtcc atctgggtcg tgacgggggt    540

actggtgtac ctggctgtgg agcggctgat ctctggggac tatgaaattg acggggggac    600

catgctgatc acgtcgggct gcgctgtggc tgtgaacatc ataatggggt tgacccttca    660

ccagtctggc catgggcaca gccacggcac caccaaccag caggaggaga accccagcgt    720

ccgagctgcc ttcatccatg tgatcggcga ctttatgcag agcatgggtg tcctagtggc    780

agcctatatt ttatacttca agccagaata caagtatgta gaccccatct gcaccttcgt    840

cttctccatc ctggtcctgg ggacaacctt gaccatcctg agagatgtga tcctggtgtt    900

gatggaaggg acccccaagg gcgttgactt cacagctgtt cgtgatctgc tgctgtcggt    960

ggagggggta gaagccctgc acagcctgca tatctgggca ctgacggtgg cccagcctgt   1020

tctgtctgtc cacatcgcca ttgctcagaa tacagacgcc caggctgtgc tgaagacagc   1080

cagcagccgc ctccaaggga agttccactt ccacaccgtg accatccaga tcgaggacta   1140

ctcggaggac atgaaggact gtcaggcatg ccagggcccc tcagactgac tgctcagcca   1200

ggcaccaact ggggcatgaa caggacctgc aggtggctgg actgagtgtc ccccaggccc   1260

agccaggact ttgcctaccc cagctgtgtt gtaaaccagg tccccctcct gacctctgcc   1320

ccactccagg aatggagctc ttcccagcct cccatctgac tacagccagg gtggggactc   1380

agcgggtata aagctagtgt gaccctgctc ttccagctcc tgggccagct ctggaagggc   1440

tgtatttggg cctaatcctc agcaactgtt ctaccactcg caggggcaaa ggtggtgagc   1500

cacgggacgt ccaaggggag gctggcccca gcgcgcccat actgcctgcc tcatgcccca   1560

ttctcagcct ggctggcctt tgcctttatg aatctgagcc cctccatctg cctatagcaa   1620

taggcacggg ggtgaggacc ctcacactct catttgagcc tccctgaggc agggagccag   1680

gaggcacctg aggcctatct gtgccttagt cacttcagct atgagccaaa tgttcccttt   1740

cctggagggg agaggcttct tactaggtaa gagacaggtt tcctctttcc ttatttcctc   1800

agctgtgcca acacaaaaaa caactttggc acaggtggtg ggcagggggt agagagattt   1860

cagcttgggt tctgcactaa cagcctccaa gccccctggc acttctgttg ccctgagagt   1920

gtcccagggg attcagagtc tccagaaaga tatggctggg ccaactctgt tgcctacctg   1980

gcctgaccca gtcggagcct gacatggtgg agggaaaggg agacaagtgg ggctgcactc   2040

ggtccagagg ccagctagga gggaaaccgc agcttcctgg ggcttgtgtg tgaagattcc   2100

tgacttaggg gtggcttttg tttacaagat gcaagagggg aaacctgtcc ccgactcatc   2160

gagacaacat gcccagttat cagggagtcc tgtgtcacaa ggtctgtctc tgccattgta   2220

agcaagtgcc ttgggcgagc tggcctctgc cccacagtct catctgtaca ccgacagggt   2280

tgatgcctcc ctcacagggt tgagaacaag agccagttgg ccaagt                  2326


<210>  88
<211>  323
<212>  PRT
<213>  Homosapiens

<400>  88

Met Glu Ala Lys Glu Lys Gln His Leu Leu Asp Ala Arg Pro Ala Ile 
1               5                   10                  15      


Arg Ser Tyr Thr Gly Ser Leu Trp Gln Glu Gly Ala Gly Trp Ile Pro 
            20                  25                  30          


Leu Pro Arg Pro Gly Leu Asp Leu Gln Ala Ile Glu Leu Ala Ala Gln 
        35                  40                  45              


Ser Asn His His Cys His Ala Gln Lys Gly Pro Asp Ser His Cys Asp 
    50                  55                  60                  


Pro Lys Lys Gly Lys Ala Gln Arg Gln Leu Tyr Val Ala Ser Ala Ile 
65                  70                  75                  80  


Cys Leu Leu Phe Met Ile Gly Glu Val Val Glu Ile Leu Gly Ala Leu 
                85                  90                  95      


Val Ser Val Leu Ser Ile Trp Val Val Thr Gly Val Leu Val Tyr Leu 
            100                 105                 110         


Ala Val Glu Arg Leu Ile Ser Gly Asp Tyr Glu Ile Asp Gly Gly Thr 
        115                 120                 125             


Met Leu Ile Thr Ser Gly Cys Ala Val Ala Val Asn Ile Ile Met Gly 
    130                 135                 140                 


Leu Thr Leu His Gln Ser Gly His Gly His Ser His Gly Thr Thr Asn 
145                 150                 155                 160 


Gln Gln Glu Glu Asn Pro Ser Val Arg Ala Ala Phe Ile His Val Ile 
                165                 170                 175     


Gly Asp Phe Met Gln Ser Met Gly Val Leu Val Ala Ala Tyr Ile Leu 
            180                 185                 190         


Tyr Phe Lys Pro Glu Tyr Lys Tyr Val Asp Pro Ile Cys Thr Phe Val 
        195                 200                 205             


Phe Ser Ile Leu Val Leu Gly Thr Thr Leu Thr Ile Leu Arg Asp Val 
    210                 215                 220                 


Ile Leu Val Leu Met Glu Gly Thr Pro Lys Gly Val Asp Phe Thr Ala 
225                 230                 235                 240 


Val Arg Asp Leu Leu Leu Ser Val Glu Gly Val Glu Ala Leu His Ser 
                245                 250                 255     


Leu His Ile Trp Ala Leu Thr Val Ala Gln Pro Val Leu Ser Val His 
            260                 265                 270         


Ile Ala Ile Ala Gln Asn Thr Asp Ala Gln Ala Val Leu Lys Thr Ala 
        275                 280                 285             


Ser Ser Arg Leu Gln Gly Lys Phe His Phe His Thr Val Thr Ile Gln 
    290                 295                 300                 


Ile Glu Asp Tyr Ser Glu Asp Met Lys Asp Cys Gln Ala Cys Gln Gly 
305                 310                 315                 320 


Pro Ser Asp 
            


<210>  89
<211>  1764
<212>  DNA
<213>  Homosapiens

<400>  89
agaattcggg caccaggaga aggaagccaa caggatccga cccggtgttt tgtgacaaag     60

gcaagacccc caggtctact tagagcaaag ttagtagagg aggcagctag gcgtggctct    120

cattccttcc cacagaatgg attataagtc gagcctgatc caggatggga atcccatgga    180

gaacttggag aagcagctga tctgccctat ctgcctggag atgtttacca agccagtggt    240

catcttgccg tgccagcaca acctgtgccg gaagtgtgcc aatgacatct tccaggctgc    300

aaatccctac tggaccagcc ggggcagctc agtgtccatg tctggaggcc gtttccgctg    360

ccccacctgc cgccacgagg tgatcatgga tcgtcacgga gtgtacggcc tgcagaggaa    420

cctgctggtg gagaacatca tcgacatcta caaacaggag tgctccagtc ggccgctgca    480

gaagggcagt caccccatgt gcaaggagca cgaagatgag aaaatcaaca tctactgtct    540

cacgtgtgag gtgcccacct gctccatgtg caaggtgttt gggatccaca aggcctgcga    600

ggtggcccca ttgcagagtg tcttccaggg acaaaagact gaactgaata actgtatctc    660

catgctggtg gcggggaatg accgtgtgca gaccatcatc actcagctgg aggattcccg    720

tcgagtgacc aaggagaaca gtcaccaggt aaaggaagag ctgagccaga agtttgacac    780

gttgtatgcc atcctggatg agaagaaaag tgagttgctg cagcggatca cgcaggagca    840

ggagaaaaag cttagcttca tcgaggccct catccagcag taccaggagc agctggacaa    900

gtccacaaag ctggtggaaa ctgccatcca gtccctggac gagcctgggg gagccacctt    960

cctcttgact gccaagcaac tcatcaaaag cattgtggaa gcttccaagg gctgccagct   1020

ggggaagaca gagcagggct ttgagaacat ggacttcttt actttggatt tagagcacat   1080

agcagacgcc ctgagagcca ttgactttgg gacagatgag gaagaggaag aattcattga   1140

agaagaagat caggaagagg aagagtccac agaagggaag gaagaaggac accagtaagg   1200

agctggatga atgagaggcc cccagatgca gagagactgg agagggtggg gaggggccca   1260

gcggccttgg tgacaggccc agggtgggag gggtcggggc ccctggaggg gcaatgggga   1320

ggtgatgtct tctctctgct cagagagcag ggactagggt aggaccctca ccgctgcgtc   1380

cagcagacac tgaaccagaa ttggaaacgt gcttgaaaca atcacacagg acacttttct   1440

acattggtgc aaaatggaat attttgtaca tttttaaaat gtgatttttg tatatacttg   1500

tatatgtatg ccaatttggt gctttttgta aaggaacttt tgtataataa tgcctggtca   1560

ttgggtgacc tgcgattgtc agaaagaggg gaaggaagcc aggttgatac agctgcccac   1620

ttcctttcct gagcaggagg atggggtagc actcacaggg acgatgtgct gtatttcagt   1680

gtctatccca gacatacggg gtggtaactg agtttgtgtt atatgttgtt ttaataaatg   1740

cacaatgctc tcttcctgtt cttc                                          1764


<210>  90
<211>  353
<212>  PRT
<213>  Homosapiens

<400>  90

Met Asp Tyr Lys Ser Ser Leu Ile Gln Asp Gly Asn Pro Met Glu Asn 
1               5                   10                  15      


Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met Phe Thr Lys 
            20                  25                  30          


Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg Lys Cys Ala 
        35                  40                  45              


Asn Asp Ile Phe Gln Ala Ala Asn Pro Tyr Trp Thr Ser Arg Gly Ser 
    50                  55                  60                  


Ser Val Ser Met Ser Gly Gly Arg Phe Arg Cys Pro Thr Cys Arg His 
65                  70                  75                  80  


Glu Val Ile Met Asp Arg His Gly Val Tyr Gly Leu Gln Arg Asn Leu 
                85                  90                  95      


Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Cys Ser Ser Arg 
            100                 105                 110         


Pro Leu Gln Lys Gly Ser His Pro Met Cys Lys Glu His Glu Asp Glu 
        115                 120                 125             


Lys Ile Asn Ile Tyr Cys Leu Thr Cys Glu Val Pro Thr Cys Ser Met 
    130                 135                 140                 


Cys Lys Val Phe Gly Ile His Lys Ala Cys Glu Val Ala Pro Leu Gln 
145                 150                 155                 160 


Ser Val Phe Gln Gly Gln Lys Thr Glu Leu Asn Asn Cys Ile Ser Met 
                165                 170                 175     


Leu Val Ala Gly Asn Asp Arg Val Gln Thr Ile Ile Thr Gln Leu Glu 
            180                 185                 190         


Asp Ser Arg Arg Val Thr Lys Glu Asn Ser His Gln Val Lys Glu Glu 
        195                 200                 205             


Leu Ser Gln Lys Phe Asp Thr Leu Tyr Ala Ile Leu Asp Glu Lys Lys 
    210                 215                 220                 


Ser Glu Leu Leu Gln Arg Ile Thr Gln Glu Gln Glu Lys Lys Leu Ser 
225                 230                 235                 240 


Phe Ile Glu Ala Leu Ile Gln Gln Tyr Gln Glu Gln Leu Asp Lys Ser 
                245                 250                 255     


Thr Lys Leu Val Glu Thr Ala Ile Gln Ser Leu Asp Glu Pro Gly Gly 
            260                 265                 270         


Ala Thr Phe Leu Leu Thr Ala Lys Gln Leu Ile Lys Ser Ile Val Glu 
        275                 280                 285             


Ala Ser Lys Gly Cys Gln Leu Gly Lys Thr Glu Gln Gly Phe Glu Asn 
    290                 295                 300                 


Met Asp Phe Phe Thr Leu Asp Leu Glu His Ile Ala Asp Ala Leu Arg 
305                 310                 315                 320 


Ala Ile Asp Phe Gly Thr Asp Glu Glu Glu Glu Glu Phe Ile Glu Glu 
                325                 330                 335     


Glu Asp Gln Glu Glu Glu Glu Ser Thr Glu Gly Lys Glu Glu Gly His 
            340                 345                 350         


Gln 
    


<210>  91
<211>  4299
<212>  DNA
<213>  Homosapiens

<400>  91
agcggagcga aggcgcgagc tgcccgataa tggcggcctg cagagcccat gagagggaga     60

agcggcagcg tctaccctga ggaaggtgct cttccccatg gggactgtac caggctggag    120

aggacatggc actgcttcag agacacgaac caccttgagt ggatgtgatt ggcgatcccc    180

gtagagcagg aaagctcgtc tgctgtgcag ccggcgcaga ggattctgtg gcaggaaatt    240

agacactagg aaattcagta gcgatttgaa ggaaacctcg accttgaaga tggtgagtag    300

ccagccaaag tacgatctaa tacgggaggt aggccgaggt agttacggtg ttgtgtatga    360

agcagtcatc agaaagacct ctgcacgggt ggcagtgaag aaaattcgat gtcacgcacc    420

tgaaaatgtt gaactagccc ttcgtgagtt ctgggcacta agcagtatca agagccaaca    480

tccaaatgtg attcacttgg aggaatgcat cctacaaaag gatgggatgg tgcaaaagat    540

gtcccacggc tctaattctt ccctttattt acagcttgta gaaacttcat taaaaggaga    600

aattgccttt gatcccagaa gcgcctatta tttgtggttt gtgatggatt tttgtgacgg    660

aggagatatg aatgagtatc tgttgtccag gaaacccaat cgtaaaacta acaccagctt    720

catgcttcag ctgagcagtg ccctggcttt cttgcataaa aaccagatca tccaccgaga    780

tcttaagcct gataacatcc tgatttctca aaccaggttg gataccagtg acttggaacc    840

taccctcaag gtggctgatt ttggtctaag taaagtttgt tcagcctctg ggcagaaccc    900

agaagaacct gtcagtgtaa acaagtgttt cctttccaca gcatgtggaa cagattttta    960

catggctcct gaagtttggg aaggacatta cacagcaaaa gctgacatct ttgctctggg   1020

gattatcatc tgggcaatgc tggaaaggat cacattcata gacacagaga caaagaagga   1080

actcttgggg agttatgtaa aacaaggaac tgagattgtg cctgttgggg aggcacttct   1140

ggaaaatccc aaaatggaac ttctcattcc tgtgaagaaa aaatctatga atgggcgaat   1200

gaaacaactg attaaggaaa tgctggctgc aaaccctcag gatcgtccag atgcttttga   1260

actagaactc agattagtac aaattgcatt taaagatagc agctgggaaa cgtgacacat   1320

attatttgca aataccatgg atgatatgct gcttctgttt aacagtgatg caacattatg   1380

tggctgaaaa agaatataaa aagctagact ctaccctcta agggtttaga ttttttgtgg   1440

gatttttttt tttcctcatt tttcttaaat ccaagttggc cgttttatta gtatgtttca   1500

aatgtgtatt accaatgtgg gtgtaaattt ttaaaaaatg attattgata gaagtttggc   1560

aggaaaattc tttaagagct aacaagagaa gagagtccag ttttctggaa atatgtcttt   1620

aagtatttta gacattcctc gtcagtatta ggaatttcca tgggaaaaga ggtttgcatg   1680

ctggtaatgc aacctttgaa actttgtaaa ggaaacatat atgtatatat ttatgtatat   1740

gtaagtatgt gaatgtgcgc attttgcatt ccatatgaaa aaaatgccac gtctgtttaa   1800

attatttgat gtaggtttgg gtttttgaga tttgctggtg aagtcagtga cgaaaaataa   1860

accttccctt atcttcctac tctgcccctc cccctaatga aatcatatta agttgttttt   1920

ttttttttgt aatatacagc ttttttttta aggcatcatt ttcgagggtc taaaattatc   1980

tggtaaaaca aatgaaatta agtgatccaa agctgctgaa gtatgtttga actctccagt   2040

gccctatagc tgcaagagtt gaattagtca tgcagtcata tggcagcagg ttggtgattc   2100

agtccgacct tctttaggta accgagcatt tatttaacca actataccac tgcattggga   2160

cgtctgcact tgagcttcta caatctgata taaatctgaa tacaggatta ttctgtttga   2220

aaactttgct atgtgtgaac tgtaatactt gatacatttt tggtttgaag actttgtcta   2280

agcctcatta tactgaagtt gaagaaacca aatgagctcc accctcactt tgcctgccct   2340

gatatgatca cttgttgagt cactggagtt cctttcattt tggcactgat gctgttttct   2400

cttgtctgat ttgaaacagt actggtaata atatggttgt tgaaaatgtg atcaccttta   2460

tctaaagtgg gagaagatac atacacagta tggcaaatgg ataaaatatt gtggcatcaa   2520

ctacttttaa agtagaaaag ctatccattt tatacaatca ctgatacagt ctatgtcaaa   2580

aaaccaacag accattattc ctcttgaagt tagtttgatt ttatctttgt atggttgtct   2640

acaatttgtt ttcctgtaaa tgcagatagt taaaatctaa aggatagaat gctttcctaa   2700

aacagaacat tagcctttaa ggttaaatag actttacatt gtatctaagt taatctttat   2760

aaagcactag aatttttggt caaaagtcaa aatagtatta gaatattgaa attattgata   2820

gctttcataa tctcagcttt tttgaacttc cacaattttt ggaatatgtc ataatttttt   2880

tccctgtttc aaatgtgttc agaggaaata gaatgtaaaa catcacaaaa aaaattgcag   2940

tacataaaat ttctggacta tgttagttac ttgatctgga agtttaaaat ttggactaaa   3000

aggttttatt gaaataaagc ctcttaaaat gaaaaatcat atacttttaa catcactttt   3060

aagctaataa atataagaat tcttttggaa attagaggtg gaaacacact ggaacctcat   3120

gataattgac cctctggatc accagattag tttaatttaa cagatatgtc caaggaagtt   3180

gagctatagg gagtaagaaa aagcatcatg ataacgtcta gtcaataaca tggcacttca   3240

gcagagattc atagatgatg gtatgcccat gcatcatttg ctcttcaaat atctatgtgc   3300

ttggagccac agtttcctaa gcgcatagtt tttggtcctg cctcatgtaa aatagttaat   3360

gattatcatt tacttggaaa gattttacct gtgaagtgaa attctttcat tgggggtaag   3420

ggtatgaggt gatcaggaag tttcttctgg aattttatca agtccttgta ttctaaaata   3480

gccaagcaaa atgatagtaa attctttgtc tttgttcttt cagtcagagg tatttattaa   3540

gtacctactg tgtgctcagc actaaaggtt tgttgataaa atgacaatta aaaaatggca   3600

tttagccaaa ggccttttca gccaggagta agaaaagatg gttagtgata tttggaaata   3660

cctggatatt tgctagagga aaaatgaaag caaaacttcg tacacagtgc cttgcccata   3720

ataggtactc aataagcaat tgttcctcat agagtctttt gccatgattt atggtgtttt   3780

ttgaaatttg tcttaattga aaaaagacca aatatttcaa atgagcttat aggcagctgt   3840

ggccagtgaa aatatggggt tgtacagtta gttcctagaa tgttattttg cactagttgt   3900

cacttagaaa gatggggttc ctgtagattt tttggtgcta agggatactt tgtcattatg   3960

atgaagtaag tgttaagtgt cagataaata gcacacagaa tagttctttc tgctggtctg   4020

ttttttctct tcgttgttgt tgtttttaat tgtaaattgt tatcaatcaa actattgtag   4080

cagctacaaa gtaattcacc agcatgacaa aatggtcaaa aaataagtca tcagcactta   4140

agaaatgaaa gcaacttttg aaattttctg ttaaaattgt caaatatatt ttatgaagaa   4200

tttataaaag gggaaaatga ttgtaattta ttgttcatga cttttttttt taaataaagt   4260

gagtttcaac aaaaaaaaaa ccgaaaaaaa aaaaaaaaa                          4299


<210>  92
<211>  341
<212>  PRT
<213>  Homosapiens

<400>  92

Met Val Ser Ser Gln Pro Lys Tyr Asp Leu Ile Arg Glu Val Gly Arg 
1               5                   10                  15      


Gly Ser Tyr Gly Val Val Tyr Glu Ala Val Ile Arg Lys Thr Ser Ala 
            20                  25                  30          


Arg Val Ala Val Lys Lys Ile Arg Cys His Ala Pro Glu Asn Val Glu 
        35                  40                  45              


Leu Ala Leu Arg Glu Phe Trp Ala Leu Ser Ser Ile Lys Ser Gln His 
    50                  55                  60                  


Pro Asn Val Ile His Leu Glu Glu Cys Ile Leu Gln Lys Asp Gly Met 
65                  70                  75                  80  


Val Gln Lys Met Ser His Gly Ser Asn Ser Ser Leu Tyr Leu Gln Leu 
                85                  90                  95      


Val Glu Thr Ser Leu Lys Gly Glu Ile Ala Phe Asp Pro Arg Ser Ala 
            100                 105                 110         


Tyr Tyr Leu Trp Phe Val Met Asp Phe Cys Asp Gly Gly Asp Met Asn 
        115                 120                 125             


Glu Tyr Leu Leu Ser Arg Lys Pro Asn Arg Lys Thr Asn Thr Ser Phe 
    130                 135                 140                 


Met Leu Gln Leu Ser Ser Ala Leu Ala Phe Leu His Lys Asn Gln Ile 
145                 150                 155                 160 


Ile His Arg Asp Leu Lys Pro Asp Asn Ile Leu Ile Ser Gln Thr Arg 
                165                 170                 175     


Leu Asp Thr Ser Asp Leu Glu Pro Thr Leu Lys Val Ala Asp Phe Gly 
            180                 185                 190         


Leu Ser Lys Val Cys Ser Ala Ser Gly Gln Asn Pro Glu Glu Pro Val 
        195                 200                 205             


Ser Val Asn Lys Cys Phe Leu Ser Thr Ala Cys Gly Thr Asp Phe Tyr 
    210                 215                 220                 


Met Ala Pro Glu Val Trp Glu Gly His Tyr Thr Ala Lys Ala Asp Ile 
225                 230                 235                 240 


Phe Ala Leu Gly Ile Ile Ile Trp Ala Met Leu Glu Arg Ile Thr Phe 
                245                 250                 255     


Ile Asp Thr Glu Thr Lys Lys Glu Leu Leu Gly Ser Tyr Val Lys Gln 
            260                 265                 270         


Gly Thr Glu Ile Val Pro Val Gly Glu Ala Leu Leu Glu Asn Pro Lys 
        275                 280                 285             


Met Glu Leu Leu Ile Pro Val Lys Lys Lys Ser Met Asn Gly Arg Met 
    290                 295                 300                 


Lys Gln Leu Ile Lys Glu Met Leu Ala Ala Asn Pro Gln Asp Arg Pro 
305                 310                 315                 320 


Asp Ala Phe Glu Leu Glu Leu Arg Leu Val Gln Ile Ala Phe Lys Asp 
                325                 330                 335     


Ser Ser Trp Glu Thr 
            340     


<210>  93
<211>  1512
<212>  DNA
<213>  Homosapiens

<400>  93
gagtgaggtt tggctgccac caaagttact tctagtcctt gctgtccact cctgccctca     60

gtctggacct gcccaaggac ccctgcaatt aggcctccca tgcagaggtc agtgagagcc    120

caagccaatt gctctaggcc ccgtggctgg ctacttatgg ggcactgtcc tgaccagctc    180

tgctaagatg ctcctggccc ctccctccac cccgtccaga ggacggaccc ccagcgccgt    240

ggagaggctg gaagccgaca aagccaagta tgtcaagacg caccaggtga tagctaggcg    300

acaggagcca gccctgcgtg ggagtcctgg gccgctcacg ccgcacccct gcaacgagct    360

ggggccccct gcatcgccca ggacgcccag gccggtccgc cggggaagcg gcaggcggct    420

gccgaggcct gattccctca tcttctaccg ccagcaaggc ttcggtgaac aaagagaacg    480

ccaagggcca gggtctggtg cggcgcctct ttctgggtgc cccgcgggac gctgccccga    540

gcagcccggc ctccacagag cgacctgcgg cttcaggggg ttgggctgcg ccccaggatg    600

ccccggaagc ggcgggaaag cgggcgctgt gtcccacgtg ctcgctgccc ctgtcggaga    660

aggagcgctt cttcaactac tgcggcctgg agcgcgcgct ggtggaggtg ctgggcgcag    720

agcgcttctc cccgcagagc tggggagccg acgccagccc gcaggccgga acttcgccgc    780

cgcccggctc cggggacgcc agcgactgga catccagcga caggggcgtg gacagcccgg    840

gcggcgcggg cggcggcggc ggctcggagg cagcgggctc ggcgcgggac cggcgccccc    900

cggtgtcggt ggtggagcgc aacgcgcgcg tcatccagtg gctgtacggc tgccagcgcg    960

cccgcggacc gccgcgcgag tccgaggtgt gaccgccgcg gctccggact ggccccggga   1020

ctggccccgg gcacggaaaa ggacacccct cttctggcgc gctgggtgcc tttgcgtaag   1080

cccttccttc tggaactcag tttagcgtct gaaccttggg gaggtggaac aagttgctgc   1140

cgaaggccct tccctgctcc cgcggcgaag ggggagggag aggcctcttg gtccctgtgg   1200

agacccggtc tggggagtca cgattggggt gggagatgag caaacctgct gaataaagtt   1260

aaaacgttat ttaaatgggg agctgaggaa ggagcaaacg ggttttcgcg gttaaacccg   1320

tgggttttgg aatgtgtgtt cccggctgtg tgatcctggg caagaacttg acctccctgg   1380

acgcagcggc acccctcggt tattaaggag ggaggagtag gggatagaag tatttcaaaa   1440

tagttgtaat gcgcatggca aagtgcccag catatagaaa gtgctcaata aacgataact   1500

gctgtgactt ct                                                       1512


<210>  94
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  94

Met Leu Leu Ala Pro Pro Ser Thr Pro Ser Arg Gly Arg Thr Pro Ser 
1               5                   10                  15      


Ala Val Glu Arg Leu Glu Ala Asp Lys Ala Lys Tyr Val Lys Thr His 
            20                  25                  30          


Gln Val Ile Ala Arg Arg Gln Glu Pro Ala Leu Arg Gly Ser Pro Gly 
        35                  40                  45              


Pro Leu Thr Pro His Pro Cys Asn Glu Leu Gly Pro Pro Ala Ser Pro 
    50                  55                  60                  


Arg Thr Pro Arg Pro Val Arg Arg Gly Ser Gly Arg Arg Leu Pro Arg 
65                  70                  75                  80  


Pro Asp Ser Leu Ile Phe Tyr Arg Gln Gln Gly Phe Gly Glu Gln Arg 
                85                  90                  95      


Glu Arg Gln Gly Pro Gly Ser Gly Ala Ala Pro Leu Ser Gly Cys Pro 
            100                 105                 110         


Ala Gly Arg Cys Pro Glu Gln Pro Gly Leu His Arg Ala Thr Cys Gly 
        115                 120                 125             


Phe Arg Gly Leu Gly Cys Ala Pro Gly Cys Pro Gly Ser Gly Gly Lys 
    130                 135                 140                 


Ala Gly Ala Val Ser His Val Leu Ala Ala Pro Val Gly Glu Gly Ala 
145                 150                 155                 160 


Leu Leu Gln Leu Leu Arg Pro Gly Ala Arg Ala Gly Gly Gly Ala Gly 
                165                 170                 175     


Arg Arg Ala Leu Leu Pro Ala Glu Leu Gly Ser Arg Arg Gln Pro Ala 
            180                 185                 190         


Gly Arg Asn Phe Ala Ala Ala Arg Leu Arg Gly Arg Gln Arg Leu Asp 
        195                 200                 205             


Ile Gln Arg Gln Gly Arg Gly Gln Pro Gly Arg Arg Gly Arg Arg Arg 
    210                 215                 220                 


Arg Leu Gly Gly Ser Gly Leu Gly Ala Gly Pro Ala Pro Pro Gly Val 
225                 230                 235                 240 


Gly Gly Gly Ala Gln Arg Ala Arg His Pro Val Ala Val Arg Leu Pro 
                245                 250                 255     


Ala Arg Pro Arg Thr Ala Ala Arg Val Arg Gly Val Thr Ala Ala Ala 
            260                 265                 270         


Pro Asp Trp Pro Arg Asp Trp Pro Arg Ala Arg Lys Arg Thr Pro Leu 
        275                 280                 285             


Phe Trp Arg Ala Gly Cys Leu Cys Val Ser Pro Ser Phe Trp Asn Ser 
    290                 295                 300                 


Val 
305 


<210>  95
<211>  649
<212>  DNA
<213>  Homosapiens

<400>  95
cgtgtcagtg gtggacctga cctgctcctg gccccttggc tggccgggct gtttctggcc     60

atgggtcgct cccgccggac aggcgcgcac cgagcgcact ctctagcccg gcagatgaag    120

gcgaagcggc ggcggccgga cttggatgag attcaccgcg agctgcggcc tcagggatcc    180

gcacgacccc agcccgaccc aaacgccgag ttcgaccccg acctgccagg gggcggtctg    240

caccgctgtc tggcctgcgc gaggtacttc atcgattcca ccaacctgaa gacccacttc    300

cgatccaaag accacaagaa aaggctgaag cagctgagcg tcgagcccta cagtcaggaa    360

gaggcggaga gggcagcggg tatgggatcc tatgtgcccc ccaggcggct ggcagtgccc    420

acggaagtgt ccactgaggt ccctgagatg gatacctcta cctgacatgg cctgaagatg    480

cagggcagag gaattgccca tggacagtga cgcaaggact aggctgggag ggagcgtgcc    540

aacccctttt gcctctgggt ttggggagcg gagggcctct tcttggtgcc ctgcccccaa    600

taaaggaact ggacaaagag aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                649


<210>  96
<211>  116
<212>  PRT
<213>  Homosapiens

<400>  96

Met Lys Ala Lys Arg Arg Arg Pro Asp Leu Asp Glu Ile His Arg Glu 
1               5                   10                  15      


Leu Arg Pro Gln Gly Ser Ala Arg Pro Gln Pro Asp Pro Asn Ala Glu 
            20                  25                  30          


Phe Asp Pro Asp Leu Pro Gly Gly Gly Leu His Arg Cys Leu Ala Cys 
        35                  40                  45              


Ala Arg Tyr Phe Ile Asp Ser Thr Asn Leu Lys Thr His Phe Arg Ser 
    50                  55                  60                  


Lys Asp His Lys Lys Arg Leu Lys Gln Leu Ser Val Glu Pro Tyr Ser 
65                  70                  75                  80  


Gln Glu Glu Ala Glu Arg Ala Ala Gly Met Gly Ser Tyr Val Pro Pro 
                85                  90                  95      


Arg Arg Leu Ala Val Pro Thr Glu Val Ser Thr Glu Val Pro Glu Met 
            100                 105                 110         


Asp Thr Ser Thr 
        115     


<210>  97
<211>  2530
<212>  DNA
<213>  Homosapiens

<400>  97
aaaacaggag ctgattcgag ctggcagagc tgggccatgg aaccggtaga gacctggacc     60

cccggaaagg tggcaacttg gctgagaggt cttgacgact ccctgcagga ctatcccttt    120

gaggactggc agctgcctgg caagaacctg ctccagctct gcccccaaag cctcgaggct    180

ctggctgtgc ggtctctggg acaccaggag ctcatcctgg gcggggtgga acagctccag    240

gccctgagct ccaggctaca gacagagaac ctgcaaagcc tgacagaggg acttctgggg    300

gcaacccatg acttccagag catagtccaa ggctgcctgg gggactgtgc caagacccct    360

attgatgtcc tctgtgcagc tgtggagctg ttgcatgaag ctgacgccct cctcttctgg    420

ctcagcaggt acctcttctc ccacttaaat gatttctcag catgccagga gatccgagac    480

ttgttggagg agctgagcca ggtcttgcat gaggatggtc cagcggctga gaaggagggc    540

acagtcctga ggatctgcag ccacgtggct gggatctgcc acaacatcct ggtctgctgc    600

cccaaggagc tgctggaaca gaaggccgtg ctcgagcagg tgcagctgga cagtccattg    660

ggcctagaaa ttcacaccac cagcaattgc cagcactttg tgtcccaagt ggacacccag    720

gttcccactg actcccgact gcagatccag cctggagacg aggttgtcca gatcaacgag    780

caggtggtgg tgggatggcc ccgtaagaac atggtgaggg aactgctgcg ggagccagcc    840

ggactcagct tagtgctgaa gaagatcccg ataccggaga cccccccaca gacgccccct    900

caggtcctgg actccccgca ccagaggagc ccatcactgt ctctggcccc actgtctccc    960

agggccccat ctgaagacgt ctttgccttt gacctgtctt caaaccccag tcccggaccc   1020

agccctgcct ggacagactc tgcctccctt ggccctgagc ccctgcccat ccccccggaa   1080

cccccagcca tactcccagc aggggtagca gggactccag ggctccctga atcccctgac   1140

aagagtcctg ttggtcggaa gaaatcaaaa ggcctggcga cccggctgag ccgccggcgg   1200

gtgtcatgcc gtgagctggg ccggccggac tgtgacggct ggctcctgtt gcgaaaggca   1260

ccgggcggct tcatgggccc gcgctggcgc cgccgctggt ttgtgctcaa gggacacacg   1320

ctctactggt accgccagcc ccaggatgag aaggctgagg gcctcatcaa tgtctccaac   1380

tatagtctgg aaagtggaca tgatcagaag aagaaatatg tgtttcagct cacccatgat   1440

gtgtacaaac ccttcatctt cgctgctgat accctgacag atctgagcat gtgggtgcgt   1500

catctcatta cctgcatctc caagtaccag tctccaggcc gggccccccc accccgagag   1560

gaagactgct acagtgagac cgaagcagag gacccggacg atgaggctgg gtcccactca   1620

gcctcgccca gccctgctca agctgggagt cccctccatg gagacacatc acctgcagcc   1680

acccccacac agcgcagccc acggacctcc tttggctctc tgacagacag cagtgaagag   1740

gcactggaag gaatggtacg ggggctgagg cagggtggcg tgtccctcct aggccagcca   1800

cagcccctga cccaggaaca gtggcggagc tctttcatgc ggcgcaaccg agaccctcag   1860

ctcaatgagc gagtgcaccg tgtgcgggcg ctacagagca cactcaaggc aaagctgcag   1920

gagctgcagg tcctagaaga agtgctgggt gaccctgagc tgacaggaga gaagttccgc   1980

cagtggaagg agcagaaccg ggagctgtac tcagagggcc tgggggcctg gggagtggca   2040

caggctgaag gcagctccca catcttgacc tctgactcca cagaacagtc ccccaactcc   2100

ctgccctctg accctgaaga gcactcccat ctctgccccc tgacctcaga gagcagcctc   2160

cgacctcctg acctctgacc ctggccagca ctctagctcc tgacctttga cccgagggcc   2220

acctcaaccc cagcttctga cgtgtccagg acagagcatc cctggattct gttcagggtg   2280

ggaagtagta ctgctagtca tggtctcacc ccgagctgac ccctctgcct gggctttgtg   2340

ccaccctctc ccttgccaaa gaagaaactc tccccccaaa tcctccaacc tctggggcca   2400

cagccctgcc cctccagttc cttggcagtt ctcccccaaa ccaggtctgt acaggtgttc   2460

tttattttac atgagggcta ctttccaacc aaataaagtc aatttttcta agaaaaaaaa   2520

aaaaaaaaaa                                                          2530


<210>  98
<211>  713
<212>  PRT
<213>  Homosapiens

<400>  98

Met Glu Pro Val Glu Thr Trp Thr Pro Gly Lys Val Ala Thr Trp Leu 
1               5                   10                  15      


Arg Gly Leu Asp Asp Ser Leu Gln Asp Tyr Pro Phe Glu Asp Trp Gln 
            20                  25                  30          


Leu Pro Gly Lys Asn Leu Leu Gln Leu Cys Pro Gln Ser Leu Glu Ala 
        35                  40                  45              


Leu Ala Val Arg Ser Leu Gly His Gln Glu Leu Ile Leu Gly Gly Val 
    50                  55                  60                  


Glu Gln Leu Gln Ala Leu Ser Ser Arg Leu Gln Thr Glu Asn Leu Gln 
65                  70                  75                  80  


Ser Leu Thr Glu Gly Leu Leu Gly Ala Thr His Asp Phe Gln Ser Ile 
                85                  90                  95      


Val Gln Gly Cys Leu Gly Asp Cys Ala Lys Thr Pro Ile Asp Val Leu 
            100                 105                 110         


Cys Ala Ala Val Glu Leu Leu His Glu Ala Asp Ala Leu Leu Phe Trp 
        115                 120                 125             


Leu Ser Arg Tyr Leu Phe Ser His Leu Asn Asp Phe Ser Ala Cys Gln 
    130                 135                 140                 


Glu Ile Arg Asp Leu Leu Glu Glu Leu Ser Gln Val Leu His Glu Asp 
145                 150                 155                 160 


Gly Pro Ala Ala Glu Lys Glu Gly Thr Val Leu Arg Ile Cys Ser His 
                165                 170                 175     


Val Ala Gly Ile Cys His Asn Ile Leu Val Cys Cys Pro Lys Glu Leu 
            180                 185                 190         


Leu Glu Gln Lys Ala Val Leu Glu Gln Val Gln Leu Asp Ser Pro Leu 
        195                 200                 205             


Gly Leu Glu Ile His Thr Thr Ser Asn Cys Gln His Phe Val Ser Gln 
    210                 215                 220                 


Val Asp Thr Gln Val Pro Thr Asp Ser Arg Leu Gln Ile Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Val Val Gln Ile Asn Glu Gln Val Val Val Gly Trp Pro Arg 
                245                 250                 255     


Lys Asn Met Val Arg Glu Leu Leu Arg Glu Pro Ala Gly Leu Ser Leu 
            260                 265                 270         


Val Leu Lys Lys Ile Pro Ile Pro Glu Thr Pro Pro Gln Thr Pro Pro 
        275                 280                 285             


Gln Val Leu Asp Ser Pro His Gln Arg Ser Pro Ser Leu Ser Leu Ala 
    290                 295                 300                 


Pro Leu Ser Pro Arg Ala Pro Ser Glu Asp Val Phe Ala Phe Asp Leu 
305                 310                 315                 320 


Ser Ser Asn Pro Ser Pro Gly Pro Ser Pro Ala Trp Thr Asp Ser Ala 
                325                 330                 335     


Ser Leu Gly Pro Glu Pro Leu Pro Ile Pro Pro Glu Pro Pro Ala Ile 
            340                 345                 350         


Leu Pro Ala Gly Val Ala Gly Thr Pro Gly Leu Pro Glu Ser Pro Asp 
        355                 360                 365             


Lys Ser Pro Val Gly Arg Lys Lys Ser Lys Gly Leu Ala Thr Arg Leu 
    370                 375                 380                 


Ser Arg Arg Arg Val Ser Cys Arg Glu Leu Gly Arg Pro Asp Cys Asp 
385                 390                 395                 400 


Gly Trp Leu Leu Leu Arg Lys Ala Pro Gly Gly Phe Met Gly Pro Arg 
                405                 410                 415     


Trp Arg Arg Arg Trp Phe Val Leu Lys Gly His Thr Leu Tyr Trp Tyr 
            420                 425                 430         


Arg Gln Pro Gln Asp Glu Lys Ala Glu Gly Leu Ile Asn Val Ser Asn 
        435                 440                 445             


Tyr Ser Leu Glu Ser Gly His Asp Gln Lys Lys Lys Tyr Val Phe Gln 
    450                 455                 460                 


Leu Thr His Asp Val Tyr Lys Pro Phe Ile Phe Ala Ala Asp Thr Leu 
465                 470                 475                 480 


Thr Asp Leu Ser Met Trp Val Arg His Leu Ile Thr Cys Ile Ser Lys 
                485                 490                 495     


Tyr Gln Ser Pro Gly Arg Ala Pro Pro Pro Arg Glu Glu Asp Cys Tyr 
            500                 505                 510         


Ser Glu Thr Glu Ala Glu Asp Pro Asp Asp Glu Ala Gly Ser His Ser 
        515                 520                 525             


Ala Ser Pro Ser Pro Ala Gln Ala Gly Ser Pro Leu His Gly Asp Thr 
    530                 535                 540                 


Ser Pro Ala Ala Thr Pro Thr Gln Arg Ser Pro Arg Thr Ser Phe Gly 
545                 550                 555                 560 


Ser Leu Thr Asp Ser Ser Glu Glu Ala Leu Glu Gly Met Val Arg Gly 
                565                 570                 575     


Leu Arg Gln Gly Gly Val Ser Leu Leu Gly Gln Pro Gln Pro Leu Thr 
            580                 585                 590         


Gln Glu Gln Trp Arg Ser Ser Phe Met Arg Arg Asn Arg Asp Pro Gln 
        595                 600                 605             


Leu Asn Glu Arg Val His Arg Val Arg Ala Leu Gln Ser Thr Leu Lys 
    610                 615                 620                 


Ala Lys Leu Gln Glu Leu Gln Val Leu Glu Glu Val Leu Gly Asp Pro 
625                 630                 635                 640 


Glu Leu Thr Gly Glu Lys Phe Arg Gln Trp Lys Glu Gln Asn Arg Glu 
                645                 650                 655     


Leu Tyr Ser Glu Gly Leu Gly Ala Trp Gly Val Ala Gln Ala Glu Gly 
            660                 665                 670         


Ser Ser His Ile Leu Thr Ser Asp Ser Thr Glu Gln Ser Pro Asn Ser 
        675                 680                 685             


Leu Pro Ser Asp Pro Glu Glu His Ser His Leu Cys Pro Leu Thr Ser 
    690                 695                 700                 


Glu Ser Ser Leu Arg Pro Pro Asp Leu 
705                 710             


<210>  99
<211>  1419
<212>  DNA
<213>  Homosapiens

<400>  99
atgagggata atgaaaaggc ctggtggcag caatggacct cccatacagg cctcgagggg     60

tggggcggga ctcaggagga ccgtatgggg tttggagggg cagtagctgc actgaggggc    120

cgcccctctc ccctgcagag taccattcac gagtcctacg gtcggccaga ggagcaagtg    180

ctcatcaacc gccaggaaat cacgaacaaa gcggacgcct gggacatgca ggagttcatc    240

actcacatgt acatcaagca gctgctccga caccccgcct tccaactgct gctggccctg    300

ctgctggtga tcaatgccat caccatcgct ctccgtacca actcctacct ggaccagaaa    360

cactatgagt tgttctctac catagatgac attgtgctga ccatccttct ttgtgaggtt    420

ctccttggct ggctcaatgg cttctggatt ttctggaagg acggctggaa catcctcaac    480

ttcattatcg tctttatctt gctcttgcgg ttcttcatta atgaaatcaa tattccctcc    540

atcaactaca ctctcagggc gcttcgtctg gtgcatgtgt gcatggcggt ggagcccctc    600

gcccggatca tccgcgtcat cctgcagtcg gtgcctgaca tggccaatat catggtcctc    660

atcctcttct tcatgctggt tttttccgtg tttggagtaa cactctttgg tgcattcgtg    720

cccaagcatt tccagaacat acaggttgcg ctgtacaccc tcttcatctg catcacccag    780

gacggctggg tggacatcta cagtgacttc cagacagaga agagggaata tgcaatggag    840

attgggggtg ccatctactt taccatcttc atcaccatcg gtgccttcat tggcatcaac    900

ctgttcgtca tcgtggtgac caccaacctg gagcaaatga tgaaggcagg agagcaggga    960

caacagcaac gaataacctt tagtgagaca ggcgcagagg aagaggagga gaatgaccag   1020

ctgccactgg tgcattgtgt ggtcgcccgc tcggagaaat ctggtctcct ccaggaaccc   1080

cttgcgggag gccccctgtc gaacctctca gaaaacacgt gtgacaactt ttgcttggtg   1140

cttgaggcaa tacaggagaa cctgaggcag tacaaggaga tccgagatga actcaacatg   1200

attgtggagg aggtgcgcgc aatccgcttc aaccaggagc aggagtcaga ggtgttgaac   1260

aggcgctcgt cgacgagcgg gtcgttggag actacgtcat ccaaggacat ccgccagatg   1320

tctcaacagc aagacttgct cagtgcgctc gttagcatgg aaaaggttca tgactctagc   1380

tcacaaatac tccttaaaaa acacaagagc agccactga                          1419


<210>  100
<211>  472
<212>  PRT
<213>  Homosapiens

<400>  100

Met Arg Asp Asn Glu Lys Ala Trp Trp Gln Gln Trp Thr Ser His Thr 
1               5                   10                  15      


Gly Leu Glu Gly Trp Gly Gly Thr Gln Glu Asp Arg Met Gly Phe Gly 
            20                  25                  30          


Gly Ala Val Ala Ala Leu Arg Gly Arg Pro Ser Pro Leu Gln Ser Thr 
        35                  40                  45              


Ile His Glu Ser Tyr Gly Arg Pro Glu Glu Gln Val Leu Ile Asn Arg 
    50                  55                  60                  


Gln Glu Ile Thr Asn Lys Ala Asp Ala Trp Asp Met Gln Glu Phe Ile 
65                  70                  75                  80  


Thr His Met Tyr Ile Lys Gln Leu Leu Arg His Pro Ala Phe Gln Leu 
                85                  90                  95      


Leu Leu Ala Leu Leu Leu Val Ile Asn Ala Ile Thr Ile Ala Leu Arg 
            100                 105                 110         


Thr Asn Ser Tyr Leu Asp Gln Lys His Tyr Glu Leu Phe Ser Thr Ile 
        115                 120                 125             


Asp Asp Ile Val Leu Thr Ile Leu Leu Cys Glu Val Leu Leu Gly Trp 
    130                 135                 140                 


Leu Asn Gly Phe Trp Ile Phe Trp Lys Asp Gly Trp Asn Ile Leu Asn 
145                 150                 155                 160 


Phe Ile Ile Val Phe Ile Leu Leu Leu Arg Phe Phe Ile Asn Glu Ile 
                165                 170                 175     


Asn Ile Pro Ser Ile Asn Tyr Thr Leu Arg Ala Leu Arg Leu Val His 
            180                 185                 190         


Val Cys Met Ala Val Glu Pro Leu Ala Arg Ile Ile Arg Val Ile Leu 
        195                 200                 205             


Gln Ser Val Pro Asp Met Ala Asn Ile Met Val Leu Ile Leu Phe Phe 
    210                 215                 220                 


Met Leu Val Phe Ser Val Phe Gly Val Thr Leu Phe Gly Ala Phe Val 
225                 230                 235                 240 


Pro Lys His Phe Gln Asn Ile Gln Val Ala Leu Tyr Thr Leu Phe Ile 
                245                 250                 255     


Cys Ile Thr Gln Asp Gly Trp Val Asp Ile Tyr Ser Asp Phe Gln Thr 
            260                 265                 270         


Glu Lys Arg Glu Tyr Ala Met Glu Ile Gly Gly Ala Ile Tyr Phe Thr 
        275                 280                 285             


Ile Phe Ile Thr Ile Gly Ala Phe Ile Gly Ile Asn Leu Phe Val Ile 
    290                 295                 300                 


Val Val Thr Thr Asn Leu Glu Gln Met Met Lys Ala Gly Glu Gln Gly 
305                 310                 315                 320 


Gln Gln Gln Arg Ile Thr Phe Ser Glu Thr Gly Ala Glu Glu Glu Glu 
                325                 330                 335     


Glu Asn Asp Gln Leu Pro Leu Val His Cys Val Val Ala Arg Ser Glu 
            340                 345                 350         


Lys Ser Gly Leu Leu Gln Glu Pro Leu Ala Gly Gly Pro Leu Ser Asn 
        355                 360                 365             


Leu Ser Glu Asn Thr Cys Asp Asn Phe Cys Leu Val Leu Glu Ala Ile 
    370                 375                 380                 


Gln Glu Asn Leu Arg Gln Tyr Lys Glu Ile Arg Asp Glu Leu Asn Met 
385                 390                 395                 400 


Ile Val Glu Glu Val Arg Ala Ile Arg Phe Asn Gln Glu Gln Glu Ser 
                405                 410                 415     


Glu Val Leu Asn Arg Arg Ser Ser Thr Ser Gly Ser Leu Glu Thr Thr 
            420                 425                 430         


Ser Ser Lys Asp Ile Arg Gln Met Ser Gln Gln Gln Asp Leu Leu Ser 
        435                 440                 445             


Ala Leu Val Ser Met Glu Lys Val His Asp Ser Ser Ser Gln Ile Leu 
    450                 455                 460                 


Leu Lys Lys His Lys Ser Ser His 
465                 470         


<210>  101
<211>  3961
<212>  DNA
<213>  Homosapiens

<400>  101
gcaacggccg ttagaggagc tgagggaggg aaccaccgct caccgcagac gtggtggctg     60

cagtcagtct tcccgagtga gggatttcgc cgcccgcttt caggcccgtt tggcttaaat    120

aactgtgatt gatggccatg caggagaaat atccaactga ggggatctct cacgtcactt    180

caccgagttc cgatgtgatt cagaagggca gttccctggg gactgaatgg cagaccccag    240

ttatctcgga gccctttcgg agccgcttca gccgctgttc aagtgtagcc gacagtgggg    300

acacagccat tggtacatca tgctcagata ttgcggagga tttttgcagc tcaagtggca    360

gtcctccttt ccagcccatc aaaagccacg taaccattcc aacagcccat gtgatgcctt    420

ctactttagg gacctctcct gccaagccaa attctacacc tgttggaccc tcttcctcta    480

aactcccttt gtcagggttg gctgaaagtg tgggaatgac aagaaatgga gacctcggtg    540

caatgaaaca ttctccaggc ctatctagag atctcatgta tttctctggt gctactggag    600

aaaatggaat tgagcagtcc tggtttccag cagtgggcca tgaaagacaa gaagaggcga    660

ggaagtttga tattcctagc atggaatcta ccctcaatca gtcggcaatg atggagacac    720

tttattcaga tcctcaccac cgagtccgct tccacaaccc aagaaccagc acaagtaagg    780

agttgtacag agtgttgcct gaggccaaga aggcaccggg cagcggggca gtgtttgagc    840

ggaatggacc acattctaat agcagtgggg tcctcccttt gggactccag cctgctcccg    900

ggctctccaa gcctctgccc tctcaggtgt ggcagccgag tcctgacact tggcatcccc    960

gagagcaatc ttgtgaactc agcacttgtc ggcagcagct ggaattgatt cgtttacaga   1020

tggagcaaat gcagcttcag aatggagcca tctgccacca tcctgctgct tttggtcctt   1080

cactgcccat cttagagcca gcacagtgga tcagcatctt gaacagtaat gaacaccttc   1140

tgaaggaaaa agagcttctc attgacaagc agaggaaaca catctctcag ctggagcaga   1200

aagtgcgaga gagcgaactg caagtccaca gtgccctctt gggccgccct gccccctttg   1260

gtgatgtctg cttgctgagg ctacaggaat tgcagcgaga aaacactttc ttacgtgcac   1320

agtttgcaca gaagacagaa gccttgagca gagaaaagat tgaccttgaa aagaaactct   1380

ctgcttctga agttgaagtc cagctcatca gagagtcgct caaagtggcg ttgcagaagc   1440

attctgagga agtgaagaaa caggaagaaa gggtcaaagg tcgtgataaa catatcaata   1500

atttgaaaaa gaaatgccag aaggaatcag agcagaaccg ggagaagcag cagcgtattg   1560

agaccttgga gcgctacctg gctgacctgc ccacactgga agaccatcag aagcagagcc   1620

agcagcttaa ggattctgag ttgaagagca cagagctgca ggagaaagtg actgagctgg   1680

agagtttgct ggaggagacc caggcaatct gcagagagaa ggagattcaa ctggaaagcc   1740

tgaggcagag agaagcagaa ttctcctccg ctggacatag cctgcaagat aaacagtctg   1800

tggaggagac cagtggagaa ggtccagaag tggaaatgga gtcctggcag aagcgatacg   1860

attcgctcca aaagattgtg gagaagcagc agcagaagat ggatcagttg cgctcacaag   1920

tacagagcct agagcaggaa gtggctcaag aagaaggaac aagccaggcc ctgagagagg   1980

aggcccagcg aagggattca gccctgcagc agctgcgcac agccgtgaag gagctttcag   2040

tgcaaaacca ggacttgatt gagaagaatc tgacactcca ggaacacctg cgccaggccc   2100

aaccagggtc tccaccttca ccagacacgg cccagctggc acttgagctg caccaggagt   2160

tggccagttg ccttcaagat ctgcaggctg tctgtagcat tgtgacccag agggcccagg   2220

gccatgaccc caatctctcc ctgctcctgg gcattcactc agcacagcac ccagagactc   2280

agctagattt gcagaagcca gatgtgatca agaggaaact agaagaggtt caacagctgc   2340

gtcgtgacat tgaggactta aggaccacca tgtcagacag atatgcccag gacatgggag   2400

aaaactgtgt cacacagtga ggaattctgg gggattcccc cagggaggag ctgggctgct   2460

gagagcctag tccagcaggt ttctgccctg acattctctt gtctgctatt cccagagagg   2520

tctcagaggg gaggggagag cctgcatctg ggggccaagg gctgattagg gaactgtgtc   2580

ctacccacac tggcatgttg gattacgttt gtcctgttaa ttcactctcg acggtgagtt   2640

actaattaac ttttggcagg tacaacagat aagtcctcac aaactgttcc cagccctagg   2700

ctgacatgag agacgaacag gctgtccacc tttcttctcc atccaatggg atggatccat   2760

gttcattccc acttcacacc ttggtcctgc tgattagaga gctcatcaga ggggcctgga   2820

aaggctgagc aagtaccagt gacaatggcc atttaagaat tctcaggccc catgtgccag   2880

ccttcttggg aactgagctg gctttctggg ttttctcatg cctggtctta ctgcttcttc   2940

ctcagggctc ttgttctccc agaagcctca gggtaatgtg ttggttagca cgtaactact   3000

aggattgggg ccctagggat tatagccagg actctaatct gcctaccatg ccatttaaca   3060

agagatccca ctctccagct gccttgtgtc cctagggtcc tggccatgtg tttagtgtgc   3120

taaactttct cctttgttct caggccttcc aggtagtccc cttcctggac ttaagagtgc   3180

aaactcttct ctgtggttct agccttgggc agaattatat cccagagacc acagagcaac   3240

tgtcaagctg cttaccccct cacccagggc tacagcctgt gcccagccct ctaatttgtg   3300

cctctcttgt gttgggggtg gtgggggtta ttcctttccc tttcctgctc tggcctcctt   3360

gaaagttcag agtacccagt acaagtcagc tttaaagtac agcttttagt gtttcctggg   3420

ttgtttctct ggggctttag tgagggacct ttgccctctg gtttttcttg cctcctggtt   3480

tagggagcat ctcacacttg ttagtatctg gttgttgggc cagccgtgcc tcctctagat   3540

ctggagccag gccaggcagg ggccacgtgt gggccagtca gccactacaa gatttttgct   3600

aagctttggg ctgttggcag catcttggac ctcatgcctg ggcctgaatg aggctctttc   3660

ttaagtgttt ttacaagttt gtgttttatt tatggagtga cttatccctt ccattcagag   3720

cagccccacc cagccagccc ttcagcctct gggctcctgc tgcttaaagg cagagccgcc   3780

tggttggtct ccaccctgtg cattgggagc ccagccacca tgctgacggg tatttttcct   3840

cataaagttt ataaccagtt atttatatga atctttgtta tgtccatttg tttgtattgc   3900

gtattttgat tataaaataa agtatcttaa cagacaaaaa aaaaaaaaaa aaaaaaaaaa   3960

a                                                                   3961


<210>  102
<211>  762
<212>  PRT
<213>  Homosapiens

<400>  102

Met Ala Met Gln Glu Lys Tyr Pro Thr Glu Gly Ile Ser His Val Thr 
1               5                   10                  15      


Ser Pro Ser Ser Asp Val Ile Gln Lys Gly Ser Ser Leu Gly Thr Glu 
            20                  25                  30          


Trp Gln Thr Pro Val Ile Ser Glu Pro Phe Arg Ser Arg Phe Ser Arg 
        35                  40                  45              


Cys Ser Ser Val Ala Asp Ser Gly Asp Thr Ala Ile Gly Thr Ser Cys 
    50                  55                  60                  


Ser Asp Ile Ala Glu Asp Phe Cys Ser Ser Ser Gly Ser Pro Pro Phe 
65                  70                  75                  80  


Gln Pro Ile Lys Ser His Val Thr Ile Pro Thr Ala His Val Met Pro 
                85                  90                  95      


Ser Thr Leu Gly Thr Ser Pro Ala Lys Pro Asn Ser Thr Pro Val Gly 
            100                 105                 110         


Pro Ser Ser Ser Lys Leu Pro Leu Ser Gly Leu Ala Glu Ser Val Gly 
        115                 120                 125             


Met Thr Arg Asn Gly Asp Leu Gly Ala Met Lys His Ser Pro Gly Leu 
    130                 135                 140                 


Ser Arg Asp Leu Met Tyr Phe Ser Gly Ala Thr Gly Glu Asn Gly Ile 
145                 150                 155                 160 


Glu Gln Ser Trp Phe Pro Ala Val Gly His Glu Arg Gln Glu Glu Ala 
                165                 170                 175     


Arg Lys Phe Asp Ile Pro Ser Met Glu Ser Thr Leu Asn Gln Ser Ala 
            180                 185                 190         


Met Met Glu Thr Leu Tyr Ser Asp Pro His His Arg Val Arg Phe His 
        195                 200                 205             


Asn Pro Arg Thr Ser Thr Ser Lys Glu Leu Tyr Arg Val Leu Pro Glu 
    210                 215                 220                 


Ala Lys Lys Ala Pro Gly Ser Gly Ala Val Phe Glu Arg Asn Gly Pro 
225                 230                 235                 240 


His Ser Asn Ser Ser Gly Val Leu Pro Leu Gly Leu Gln Pro Ala Pro 
                245                 250                 255     


Gly Leu Ser Lys Pro Leu Pro Ser Gln Val Trp Gln Pro Ser Pro Asp 
            260                 265                 270         


Thr Trp His Pro Arg Glu Gln Ser Cys Glu Leu Ser Thr Cys Arg Gln 
        275                 280                 285             


Gln Leu Glu Leu Ile Arg Leu Gln Met Glu Gln Met Gln Leu Gln Asn 
    290                 295                 300                 


Gly Ala Ile Cys His His Pro Ala Ala Phe Gly Pro Ser Leu Pro Ile 
305                 310                 315                 320 


Leu Glu Pro Ala Gln Trp Ile Ser Ile Leu Asn Ser Asn Glu His Leu 
                325                 330                 335     


Leu Lys Glu Lys Glu Leu Leu Ile Asp Lys Gln Arg Lys His Ile Ser 
            340                 345                 350         


Gln Leu Glu Gln Lys Val Arg Glu Ser Glu Leu Gln Val His Ser Ala 
        355                 360                 365             


Leu Leu Gly Arg Pro Ala Pro Phe Gly Asp Val Cys Leu Leu Arg Leu 
    370                 375                 380                 


Gln Glu Leu Gln Arg Glu Asn Thr Phe Leu Arg Ala Gln Phe Ala Gln 
385                 390                 395                 400 


Lys Thr Glu Ala Leu Ser Arg Glu Lys Ile Asp Leu Glu Lys Lys Leu 
                405                 410                 415     


Ser Ala Ser Glu Val Glu Val Gln Leu Ile Arg Glu Ser Leu Lys Val 
            420                 425                 430         


Ala Leu Gln Lys His Ser Glu Glu Val Lys Lys Gln Glu Glu Arg Val 
        435                 440                 445             


Lys Gly Arg Asp Lys His Ile Asn Asn Leu Lys Lys Lys Cys Gln Lys 
    450                 455                 460                 


Glu Ser Glu Gln Asn Arg Glu Lys Gln Gln Arg Ile Glu Thr Leu Glu 
465                 470                 475                 480 


Arg Tyr Leu Ala Asp Leu Pro Thr Leu Glu Asp His Gln Lys Gln Ser 
                485                 490                 495     


Gln Gln Leu Lys Asp Ser Glu Leu Lys Ser Thr Glu Leu Gln Glu Lys 
            500                 505                 510         


Val Thr Glu Leu Glu Ser Leu Leu Glu Glu Thr Gln Ala Ile Cys Arg 
        515                 520                 525             


Glu Lys Glu Ile Gln Leu Glu Ser Leu Arg Gln Arg Glu Ala Glu Phe 
    530                 535                 540                 


Ser Ser Ala Gly His Ser Leu Gln Asp Lys Gln Ser Val Glu Glu Thr 
545                 550                 555                 560 


Ser Gly Glu Gly Pro Glu Val Glu Met Glu Ser Trp Gln Lys Arg Tyr 
                565                 570                 575     


Asp Ser Leu Gln Lys Ile Val Glu Lys Gln Gln Gln Lys Met Asp Gln 
            580                 585                 590         


Leu Arg Ser Gln Val Gln Ser Leu Glu Gln Glu Val Ala Gln Glu Glu 
        595                 600                 605             


Gly Thr Ser Gln Ala Leu Arg Glu Glu Ala Gln Arg Arg Asp Ser Ala 
    610                 615                 620                 


Leu Gln Gln Leu Arg Thr Ala Val Lys Glu Leu Ser Val Gln Asn Gln 
625                 630                 635                 640 


Asp Leu Ile Glu Lys Asn Leu Thr Leu Gln Glu His Leu Arg Gln Ala 
                645                 650                 655     


Gln Pro Gly Ser Pro Pro Ser Pro Asp Thr Ala Gln Leu Ala Leu Glu 
            660                 665                 670         


Leu His Gln Glu Leu Ala Ser Cys Leu Gln Asp Leu Gln Ala Val Cys 
        675                 680                 685             


Ser Ile Val Thr Gln Arg Ala Gln Gly His Asp Pro Asn Leu Ser Leu 
    690                 695                 700                 


Leu Leu Gly Ile His Ser Ala Gln His Pro Glu Thr Gln Leu Asp Leu 
705                 710                 715                 720 


Gln Lys Pro Asp Val Ile Lys Arg Lys Leu Glu Glu Val Gln Gln Leu 
                725                 730                 735     


Arg Arg Asp Ile Glu Asp Leu Arg Thr Thr Met Ser Asp Arg Tyr Ala 
            740                 745                 750         


Gln Asp Met Gly Glu Asn Cys Val Thr Gln 
        755                 760         


<210>  103
<211>  1131
<212>  DNA
<213>  Homosapiens

<400>  103
tggagagagc ggctctcgtg gctggggagt tggatgcacc aaacctgtgt gcggctggag     60

agggaggctt ctgccagacc ctctcccggg cctgtcctgc cacccaggcc cctccccagt    120

ctcacactga gctccagatc agggaagggc cgaaaaggac gatcagggca gccgcagaag    180

gggcgccctg cgtgggacgg gtccgttgcg cgcctggtaa ccgaggggga agggaagggg    240

cctctggcgt gcggggcggt gtcgcgcagg tcccaccccg cctgcccgcg ccgcccattg    300

gtcccgagcg cgatgacttg gcgggcggag caggaaggaa accgctcccg agcacggcgg    360

cggcgtcgtc tcccggcagt gcagctgccg ctaccgccgc cctctgcccg ccggcccgtc    420

tgtctacccc cagcatgagc ggcctgcgcg tctacagcac gtcggtcacc ggctcccgcg    480

aaatcaagtc ccagcagagc gaggtgaccc gaatcctgga tgggaagcgc atccaatacc    540

agctagtgga catctcccag gacaacgccc tgagggatga gatgcgagcc ttggcaggca    600

accccaaggc caccccaccc cagattgtca acggggacca gtactgtggg gactatgagc    660

tcttcgtgga ggctgtggaa caaaacacgc tgcaggagtt cctgaagctg gcttgagtca    720

agcctgtcca gagttcccct gctggactcc atcaccacac tccccccagc cttcacctgg    780

ccatgaagga ccttttgacc aactccctgt cattcctaac ctaaccttag agtccctccc    840

ccaatgcagg ccacttctcc tccctcctct ctaaatgtag tcccctctcc tccatctaaa    900

ggcaacattc cttacccatt agtctcagaa attgtcttaa gcaacagccc caaatgctgg    960

ctgcccccag ccaagcattg gggccgccat cctgcctggc actggctgat gggcacctct   1020

gttggttcca tcagccagag ctctgccaaa ggccccgcag tccctctccc aggaggaccc   1080

tagaggcaat taaatgatgt cctgttccat tggcaaaaaa aaaaaaaaaa a            1131


<210>  104
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  104

Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val Thr Gly Ser Arg Glu 
1               5                   10                  15      


Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile Leu Asp Gly Lys Arg 
            20                  25                  30          


Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn Ala Leu Arg Asp 
        35                  40                  45              


Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala Thr Pro Pro Gln Ile 
    50                  55                  60                  


Val Asn Gly Asp Gln Tyr Cys Gly Asp Tyr Glu Leu Phe Val Glu Ala 
65                  70                  75                  80  


Val Glu Gln Asn Thr Leu Gln Glu Phe Leu Lys Leu Ala 
                85                  90              


<210>  105
<211>  1514
<212>  DNA
<213>  Homosapiens

<400>  105
cacaagatgg cggcgctgcg ggacggctag cggccctgcg tgggagttcc tgacagctgg     60

attctagaag tagaactatg agctcacctt tggcctccct tagcaagacc cgaaaagtgc    120

ccctgccctc ggagcctatg aatcctggga ggcgaggaat ccgcatctat ggagatgtcc    180

ctgcatccca tgactcggag ctgatggcct tcatgacgag gaagttgtgg gacctggagc    240

agcaggtgaa ggcccagact gatgagatac tgtccaagga tcagaagata gcggccctag    300

aggacctggt gcagaccctc cggccacacc cagccgaggc aaccctgcag cggcaggagg    360

aactggagac gatgtgtgtg cagctgcagc ggcaggtcag ggagatggag cggttcctca    420

gtgactatgg cctgcagtgg gtgggcgagc ccatggacca ggaggactca gagagcaaga    480

cagtctcaga gcatggcgag agggactgga tgacagccaa gaagttctgg aagccagggg    540

actcattggc gccccctgag gtggactttg acaggctgct ggccagcctg caggatctta    600

gtgagctggt ggtagagggt gacacccaag tgacaccagt gcccggcggg gcacggctgc    660

gtaccctcga gcccatcccg ctgaagctct accggaatgg catcatgatg ttcgacgggc    720

ccttccagcc cttctacgat ccctccacac agcgctgcct ccgagacata ttggatggct    780

tctttccctc agagctccag cgactgtacc ccaatggggt cccctttaag gtgagtgact    840

tgcgcaatca ggtctacctg gaggatggac tggacccctt cccaggcgag ggccgtgtgg    900

tgggcaggca gcggatgcac aaggccttgg acagggtgga ggagcaccca ggctccagga    960

tgactgctga gaaatttctg aacaggctcc ccaagtttgt gatccggcaa ggcgaggtga   1020

ttgacatccg gggccccatc agggacacct tgcagaactg ctgcccattg cctgcccgga   1080

tccaggagat tgtggtggag acgcccacct tggccgctga gcgagagagg agccaggagt   1140

cacccaacac gccggcaccc ccgctctcca tgctgcgcat caagtctgag aatggggaac   1200

aggccttcct actgatgatg cagcctgaca acaccattgg ggacgtgcga gctctgctag   1260

cgcaggccag ggtcatggat gcctctgcct ttgagatctt cagcacattc ccgcccaccc   1320

tctaccagga cgatacactc acgctgcagg ctgcaggcct tgtgcccaaa gcagcactgc   1380

tgctgcgggc acgccgagcc ccgaagtcca gcctgaaatt cagtcctggt ccctgtcccc   1440

ccggtcccgg tcccggcccc agtccctgtc ctggacccag tcccagcccc caataaagca   1500

cccgccccct caaa                                                     1514


<210>  106
<211>  472
<212>  PRT
<213>  Homosapiens

<400>  106

Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr Arg 
        35                  40                  45              


Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu Ile 
    50                  55                  60                  


Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln Thr 
65                  70                  75                  80  


Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu Leu 
                85                  90                  95      


Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu Arg 
            100                 105                 110         


Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp Gln 
        115                 120                 125             


Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp Trp 
    130                 135                 140                 


Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro Pro 
145                 150                 155                 160 


Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser Glu 
                165                 170                 175     


Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly Ala 
            180                 185                 190         


Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn Gly 
        195                 200                 205             


Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser Thr 
    210                 215                 220                 


Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu Leu 
225                 230                 235                 240 


Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu Arg 
                245                 250                 255     


Asn Gln Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu Gly 
            260                 265                 270         


Arg Val Val Gly Arg Gln Arg Met His Lys Ala Leu Asp Arg Val Glu 
        275                 280                 285             


Glu His Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg Leu 
    290                 295                 300                 


Pro Lys Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly Pro 
305                 310                 315                 320 


Ile Arg Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile Gln 
                325                 330                 335     


Glu Ile Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg Ser 
            340                 345                 350         


Gln Glu Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg Ile 
        355                 360                 365             


Lys Ser Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro Asp 
    370                 375                 380                 


Asn Thr Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val Met 
385                 390                 395                 400 


Asp Ala Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu Tyr 
                405                 410                 415     


Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys Ala 
            420                 425                 430         


Ala Leu Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys Phe 
        435                 440                 445             


Ser Pro Gly Pro Cys Pro Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys 
    450                 455                 460                 


Pro Gly Pro Ser Pro Ser Pro Gln 
465                 470         


<210>  107
<211>  1771
<212>  DNA
<213>  Homosapiens

<400>  107
aaaaaaccgc gtgacaacaa gatggcggcg ctgcgggacg gctagcggcc ctgcgtgtac     60

tttcccaagc accaccaggc caaaggtctc tcagttcaga gcagaaagcc gtatacccag    120

aggagcaggc agataacaga aacttccaga aacctctgtg gagacagtgg aagaggcaaa    180

agggagttcc tgacagctgg attctagaag tagaactatg agctcacctt tggcctccct    240

tagcaagacc cgaaaagtgc ccctgccctc ggagcctatg aatcctggga ggcgaggaat    300

ccgcatctat ggagatgaag atgaggtgga catgttgagt gatgggtgtg gctcggaaga    360

aaagatctca gtcccttcct gctatggcgg cataggtgcc cctgtgagtc ggcaagtccc    420

tgcatcccat gactcggagc tgatggcctt catgacgagg aagttgtggg acctggagca    480

gcaggtgaag gcccagactg atgagatact gtccaaggat cagaagatag cggccctaga    540

ggacctggtg cagaccctcc ggccacaccc agccgaggca accctgcagc ggcaggagga    600

actggagacg atgtgtgtgc agctgcagcg gcaggtcagg gagatggagc ggttcctcag    660

tgactatggc ctgcagtggg tgggcgagcc catggaccag gaggactcag agagcaagac    720

agtctcagag catggcgaga gggactggat gacagccaag aagttctgga agccagggga    780

ctcattggcg ccccctgagg tggactttga caggctgctg gccagcctgc aggatcttag    840

tgagctggtg gtagagggtg acacccaagt gacaccagtg cccggcgggg cacggctgcg    900

taccctcgag cccatcccgc tgaagctcta ccggaatggc atcatgatgt tcgacgggcc    960

cttccagccc ttctacgatc cctccacaca gcgctgcctc cgagacatat tggatggctt   1020

ctttccctca gagctccagc gactgtaccc caatggggtc ccctttaagg tgagtgactt   1080

gcgcaatcag gtctacctgg aggatggact ggaccccttc ccaggcgagg gccgtgtggt   1140

gggcaggcag cggatgcaca aggccttgga cagggtggag gagcacccag gctccaggat   1200

gactgctgag aaatttctga acaggctccc caagtttgtg atccggcaag gcgaggtgat   1260

tgacatccgg ggccccatca gggacacctt gcagaactgc tgcccattgc ctgcccggat   1320

ccaggagatt gtggtggaga cgcccacctt ggccgctgag cgagagagga gccaggagtc   1380

acccaacaca ccggcacccc cgctctccat gctgcgcatc aagtctgaga atggggaaca   1440

ggccttccta ctgatgatgc agcctgacaa caccattggg gacgtgcgag ctctgctagc   1500

gcaggccagg gtcatggatg cctctgcctt tgagatcttc agcacattcc cgcccaccct   1560

ctaccaggac gatacactca cgctgcaggc tgcaggcctt gtgcccaaag cagcactgct   1620

gctgcgggca cgccgagccc cgaagtccag cctgaaattc agtcctggtc cctgtcccgg   1680

tcccggtccc ggccccagtc ccggtcccgg tcccggctcc agtccctgtc ccggacccag   1740

tcccagcccc caataaagca cccgccccct c                                  1771


<210>  108
<211>  512
<212>  PRT
<213>  Homosapiens

<400>  108

Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Glu Asp Glu Val Asp Met Leu Ser Asp Gly Cys Gly Ser Glu Glu 
        35                  40                  45              


Lys Ile Ser Val Pro Ser Cys Tyr Gly Gly Ile Gly Ala Pro Val Ser 
    50                  55                  60                  


Arg Gln Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr 
65                  70                  75                  80  


Arg Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu 
                85                  90                  95      


Ile Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln 
            100                 105                 110         


Thr Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu 
        115                 120                 125             


Leu Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu 
    130                 135                 140                 


Arg Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp 
145                 150                 155                 160 


Gln Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp 
                165                 170                 175     


Trp Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro 
            180                 185                 190         


Pro Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser 
        195                 200                 205             


Glu Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly 
    210                 215                 220                 


Ala Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn 
225                 230                 235                 240 


Gly Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser 
                245                 250                 255     


Thr Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu 
            260                 265                 270         


Leu Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu 
        275                 280                 285             


Arg Asn Gln Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu 
    290                 295                 300                 


Gly Arg Val Val Gly Arg Gln Arg Met His Lys Ala Leu Asp Arg Val 
305                 310                 315                 320 


Glu Glu His Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg 
                325                 330                 335     


Leu Pro Lys Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly 
            340                 345                 350         


Pro Ile Arg Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile 
        355                 360                 365             


Gln Glu Ile Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg 
    370                 375                 380                 


Ser Gln Glu Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg 
385                 390                 395                 400 


Ile Lys Ser Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro 
                405                 410                 415     


Asp Asn Thr Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val 
            420                 425                 430         


Met Asp Ala Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu 
        435                 440                 445             


Tyr Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys 
    450                 455                 460                 


Ala Ala Leu Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys 
465                 470                 475                 480 


Phe Ser Pro Gly Pro Cys Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly 
                485                 490                 495     


Pro Gly Pro Gly Ser Ser Pro Cys Pro Gly Pro Ser Pro Ser Pro Gln 
            500                 505                 510         


<210>  109
<211>  2532
<212>  DNA
<213>  Homosapiens

<400>  109
aagggacttc cgtgctcccg gcgagcgggc ggagagcggg ggccgcactg gggagtgtgg     60

gctgggccgc agatgtcatg tggcctgtgt tttggaccgt ggttcgtacc tatgctcctt    120

atgtcacatt ccctgttgcc ttcgtggtcg gggctgtggg ttaccacctg gaatggttca    180

tcaggggaaa ggacccccag cccgtggagg aggaaaagag catctcagag cgccgggagg    240

atcgcaagct ggatgagctt ctaggcaagg accacacgca ggtggtgagc cttaaggaca    300

agctagaatt tgccccgaaa gctgtgctga acagaaaccg cccagagaag aattaatgga    360

ggacacaggg ccctatggtc ctactgtggg tggtgacttg tcctgctacc atgttgacag    420

agccccagaa cccacatcta attggctttg ttgcttattc tggcccttcc cacaccacac    480

agccacacaa atactggctg ctccttgatg gccaggcaga cccagcagca gccgaggggc    540

cagtgaagag gaaggccgca tctgttgtgt ggtggccaca agcactcagg catctgagtt    600

tactggtgca ctgctgggag gagagttatg agatgaacat tggctgtcaa tctctgtggg    660

caggcggttt ggcctctagt gggaatggct gggatttggg cgttgccttt aggagggata    720

cctgcatgtc tagttccagt ctgcactgga aagaattcaa atatgcacct ggctcccttc    780

actattttgc cctatccttt gtgctcattc ttactgaaat ctgtcttgtc agctcaggaa    840

tgggattccc ccaggaagga aagcactttt ctgttctggg aagcccagac tgttcacttt    900

ggggcaggga cgaacatgtg cctcgtgaat ttgcttgaaa acagtcacca tcttctaccc    960

ccatcactgt atagtgaaaa acctgattaa agtggtatct gagaaccata atgatcgaat   1020

cttatcatcc aggtggtatt tgggggtctt cttaggagtt aggcaagtac aggcatttta   1080

gagcaggata acattggtat taaagggtgc caaggagccc tggaaactgc tttactagtg   1140

cggttgcact gaaccctgga ggcacagatt cccaggaacc tttttaccat tattacaatt   1200

ggctgcagca ccttcaagtc taaatggagg tagacctcac atacacacac atagacgcct   1260

ttccctataa aagtatatac gcacattcaa gaaaatttgg tagggatttt aaaaaggtca   1320

cccatgttcc cagctcgtta ataacaaccg ttaacatttt gttgtctttt actaattctc   1380

tgcataggtt ttagagatag ttatcattac tgtacattta attttatata cttttctcac   1440

tattatcatt ttcccatttt acatggtcat cataattggt tttttggaga cagggtctca   1500

ctctgtcaca caggctggag tgcagtacaa ttacggctca gtgcaacctt gacctcctgg   1560

gctcaagtga tcctctcact tcagctcctc aagtagatgg gactacagga gtatgccacc   1620

atgcccagct aattttttta tttttttgta gaaccaggtc tcactatgtt gcccaggcta   1680

gtctcaaact cctgggctca agtgatcctc cggccttggc ctgtagtttc ttttttcttt   1740

ttttttggag atggactctc attctgtcac ccgggctgga gtgcagtggc gtgatcttgg   1800

ctgactgcaa cttctgcctc ctgggttcaa gcgattctcc tacctcagct tcctaagtag   1860

ctgggattac aggcgtgcgc catcgtgcct ggctagtttt tgtgttttta gtaaagacag   1920

gggtttcacc atcttggcca ggctggtctc gaactcctga cctcaagcga tcccatctgc   1980

ctcggcctcc caaagtgctg ggattacagg tgtgaggcac cgtgcctggc agtctgtagt   2040

ttttttttgt tgttgttgtt gttgttgttt taaatatgga gtctcgctgt attgcccagg   2100

ctggagtgca gtggcgcgat cttggttcac tgcaacctcc acctcttggg ttcaagcgat   2160

tctcctgcct cagcctcctg agtagctggg attacaggtg tgcgccgcta cgcctggcta   2220

atttttgtat ttttagtaga gacagggttt caccatgttg gtcaggctgg tctcaaactt   2280

ctgaccttgt gatctgcctg ccttggcctc ctaaagtgct gggattacag gcgtgagcca   2340

ccgtgcctgg ctgtagttgt ttataatagc aacataattg tctatcaagt gggagtatga   2400

cataagttta tcctggacaa tttccatatt gctggacatt tgaattgttt ctggttggtc   2460

actcgtttag atactgcaac gaatatctta tatgaagctt ttcctgcgtt ttggaataaa   2520

cagtaaaaat ag                                                       2532


<210>  110
<211>  187
<212>  PRT
<213>  Homosapiens

<400>  110

Met Val Leu Leu Trp Val Val Thr Cys Pro Ala Thr Met Leu Thr Glu 
1               5                   10                  15      


Pro Gln Asn Pro His Leu Ile Gly Phe Val Ala Tyr Ser Gly Pro Ser 
            20                  25                  30          


His Thr Thr Gln Pro His Lys Tyr Trp Leu Leu Leu Asp Gly Gln Ala 
        35                  40                  45              


Asp Pro Ala Ala Ala Glu Gly Pro Val Lys Arg Lys Ala Ala Ser Val 
    50                  55                  60                  


Val Trp Trp Pro Gln Ala Leu Arg His Leu Ser Leu Leu Val His Cys 
65                  70                  75                  80  


Trp Glu Glu Ser Tyr Glu Met Asn Ile Gly Cys Gln Ser Leu Trp Ala 
                85                  90                  95      


Gly Gly Leu Ala Ser Ser Gly Asn Gly Trp Asp Leu Gly Val Ala Phe 
            100                 105                 110         


Arg Arg Asp Thr Cys Met Ser Ser Ser Ser Leu His Trp Lys Glu Phe 
        115                 120                 125             


Lys Tyr Ala Pro Gly Ser Leu His Tyr Phe Ala Leu Ser Phe Val Leu 
    130                 135                 140                 


Ile Leu Thr Glu Ile Cys Leu Val Ser Ser Gly Met Gly Phe Pro Gln 
145                 150                 155                 160 


Glu Gly Lys His Phe Ser Val Leu Gly Ser Pro Asp Cys Ser Leu Trp 
                165                 170                 175     


Gly Arg Asp Glu His Val Pro Arg Glu Phe Ala 
            180                 185         


<210>  111
<211>  3581
<212>  DNA
<213>  Homosapiens

<400>  111
atgaggggtt accatggcga ccgaggcagc catccccgcc cagcccgctt tgctgaccaa     60

cagcatatgg acgtgggccc tgctgccagg gccccatacc tgctgggctc cagggaggcc    120

ttctccaccg agccccgctt ctgtgccccg agagctggcc tgggacacat ttctcctgaa    180

gggcccctga gcctgagtga ggggccgtcg gtaggccctg agggagggcc agcgggggcc    240

ggggttgggg ggggtagcag caccttcccc aggatgtacc ctggccaggg ccccttcgac    300

acctgtgaag actgtgtggg ccacccacag ggcaagggtg ccccccgcct gcctcctaca    360

ctcctggatc agtttgaaaa gcagttgcca gttcaacaag atggcttcca cacactacca    420

taccagcgag ggccagcagg ggcagggccc gggccagcgc cagggacggg cactgcccca    480

gagccccgca gtgagagccc tagccgcatc cggcacctgg ttcattctgt gcagaagctc    540

tttgccaagt cccactctct ggaggcgccg gggaagcggg actataatgg gcccaaggct    600

gagggaagag gtggctctgg aggagacagc taccccggcc cgggctctgg aggcccccac    660

acctcccatc accaccatca ccaccaccat caccaccacc accagtcccg gcacggcaag    720

aggagcaaga gcaaggaccg caagggggat gggcggcacc aggccaagtc cacaggctgg    780

tggagttccg atgacaactt ggacagtgat agcggcttcc tggcgggtgg gaggccccct    840

ggggagcctg gtggtccctt ctgcctggag ggtccagatg ggtcctaccg ggacttgagc    900

ttcaaggggc gctcgggcgg gtcggaaggc cgctgccttg cctgcactgg catgtccatg    960

tcactggatg gacagtcggt caagcgaagt gcctggcata ccatgatggt cagccagggc   1020

cgggatggat acccgggggc cgggccaggc aaggggctcc tgggtccgga gaccaaggcc   1080

aaagccagga cttatcacta tctgcaggtg ccgcaagatg actggggggg ttaccccacc   1140

ggtggcaagg atggggagat cccctgccgc aggatgcgga gcggcagcta catcaaagcc   1200

atgggggatg aggagagcgg agactcagac ggcagcccca agacatctcc caaagcagtc   1260

gcccgacgct tcaccacccg tcgctcctcc agcgtggacc aggccaggat caactgctgt   1320

gtcccacccc ggatccaccc ccggagctcc atccctggct acagccgttc cctcaccact   1380

ggacagctca gcgatgagtt gaaccagcag ctggaggccg tgtgcgggtc ggtgtttggg   1440

gagctggagt cccaggccgt ggacgccctg gacctgcccg gctgtttccg catgcggagc   1500

cacagctacc tccgggccat ccaggccggc tgctctcaag acgacgactg cctgcccctc   1560

ctcgctaccc ctgccgctgt ctcagggagg cccggctcct ccttcaactt cagaaaggcc   1620

ccgcccccca tcccgccggg aagccaggcc ccgccccgca tctccatcac cgcccagagc   1680

agcaccgact ccgcgcacga gagcttcacg gcggccgagg gccccgcccg gcgctgcagc   1740

tccgccgacg ggctggacgg ccccgccatg ggtgcgcgca cactggagtt ggcgccggtg   1800

ccgccccggg ccagccccaa gccccccaca ctcatcatca agaccatccc tggcagggag   1860

gagctgcgga gcctggcgcg gcagcggaag tggcggccgt ccattggggt gcaggtggag   1920

acgatctcag attcggacac cgagaacagg agccggaggg agttccactc tattggcgtg   1980

caggtggaag aggacaagag gcgagcaagg ttcaagcgct ccaatagtgt gacggctggc   2040

gtgcaggcag acctggagct ggagggcctg gcaggcctgg ccacggtggc cacagaagac   2100

aaggccctgc agtttggacg ctccttccag aggcacgcct ctgagcccca gcctgggccc   2160

cgggccccca cctactcagt cttccgcacg gtccacacgc agggccagtg ggcctaccgc   2220

gagggctacc cactgccgta cgagccgccg gccaccgatg ggtcgcccgg ccctgccccc   2280

gcccccaccc ccggccctgg ggccggccgc cgtgactcct ggatagagcg cggttcacgt   2340

agcctccccg actcaggccg cgcatccccc tgcccacgcg acggcgagtg gttcatcaag   2400

atgctgcggg cagaggtgga gaagctggag cactggtgcc agcagatgga gcgtgaggcg   2460

gaggactatg agctacccga ggagatcctg gagaagatcc gcagtgctgt gggcagcaca   2520

caacttctcc tgtcccagaa ggttcagcag ttcttccggc tgtgtcagca aagcatggat   2580

cccactgcgt tccctgtgcc caccttccag gacctggcgg gtttctggga cctcctacag   2640

ctctccatcg aggatgtgac cctcaagttc ctggagctac agcaactcaa ggccaacagc   2700

tggaaactcc tggagcctaa ggaggagaag aaggtccctc cgccgatacc aaagaagccc   2760

ctgcggggcc ggggcgtgcc ggtgaaggag cgctccctgg actccgtgga ccggcagcgg   2820

caggaagcgc gcaagcggct cctggcggcc aagcgcgccg cttccttccg ccacagctcg   2880

gccaccgaga gcgccgacag catcgagatc tacatccccg aggcccagac caggctgtga   2940

ccggtccggc ccgcccagcc cggcccgggc ccgcggttct ccacccgtac tgtacaccca   3000

gcgtcgaggt cactgtgaac gcgggccgcc ccgtgcgccc gccccaccgg caccggacgc   3060

cccggccccc gggcccgtca cactctcgtg ggttttttac cttcctgatc ccacgcgaag   3120

gcgcccgggc tgggcagggg gccgtgcctc tccgccctgc gcccctcacc tggatcccct   3180

gcccacctgg tccgacgctt tgtccccacc tcctccccat gggcaccatc tctgccattc   3240

tttcccccac gggccaggcc gggccgggtc cctcatctgg gctctgcgtc cccccctccc   3300

ccaccccgcg gggctgggct tcgtggggat caagcttcgt ggctttttat gaagaatccc   3360

gaaccctgcc taggagcccg ccccaccctc ccaggggctc catcctcagc cctctgccca   3420

ctgggcccag ggaccacagt ggctggacca acccaggacc agggcgcctg ggcctctccc   3480

ctttcccagc ggctggggag gggagatggg ggcttcccct caccacacct gtggctgttc   3540

ccacatcccc ttgaatatcc caggaaaaat aaaacggcag a                       3581


<210>  112
<211>  979
<212>  PRT
<213>  Homosapiens

<400>  112

Met Arg Gly Tyr His Gly Asp Arg Gly Ser His Pro Arg Pro Ala Arg 
1               5                   10                  15      


Phe Ala Asp Gln Gln His Met Asp Val Gly Pro Ala Ala Arg Ala Pro 
            20                  25                  30          


Tyr Leu Leu Gly Ser Arg Glu Ala Phe Ser Thr Glu Pro Arg Phe Cys 
        35                  40                  45              


Ala Pro Arg Ala Gly Leu Gly His Ile Ser Pro Glu Gly Pro Leu Ser 
    50                  55                  60                  


Leu Ser Glu Gly Pro Ser Val Gly Pro Glu Gly Gly Pro Ala Gly Ala 
65                  70                  75                  80  


Gly Val Gly Gly Gly Ser Ser Thr Phe Pro Arg Met Tyr Pro Gly Gln 
                85                  90                  95      


Gly Pro Phe Asp Thr Cys Glu Asp Cys Val Gly His Pro Gln Gly Lys 
            100                 105                 110         


Gly Ala Pro Arg Leu Pro Pro Thr Leu Leu Asp Gln Phe Glu Lys Gln 
        115                 120                 125             


Leu Pro Val Gln Gln Asp Gly Phe His Thr Leu Pro Tyr Gln Arg Gly 
    130                 135                 140                 


Pro Ala Gly Ala Gly Pro Gly Pro Ala Pro Gly Thr Gly Thr Ala Pro 
145                 150                 155                 160 


Glu Pro Arg Ser Glu Ser Pro Ser Arg Ile Arg His Leu Val His Ser 
                165                 170                 175     


Val Gln Lys Leu Phe Ala Lys Ser His Ser Leu Glu Ala Pro Gly Lys 
            180                 185                 190         


Arg Asp Tyr Asn Gly Pro Lys Ala Glu Gly Arg Gly Gly Ser Gly Gly 
        195                 200                 205             


Asp Ser Tyr Pro Gly Pro Gly Ser Gly Gly Pro His Thr Ser His His 
    210                 215                 220                 


His His His His His His His His His His Gln Ser Arg His Gly Lys 
225                 230                 235                 240 


Arg Ser Lys Ser Lys Asp Arg Lys Gly Asp Gly Arg His Gln Ala Lys 
                245                 250                 255     


Ser Thr Gly Trp Trp Ser Ser Asp Asp Asn Leu Asp Ser Asp Ser Gly 
            260                 265                 270         


Phe Leu Ala Gly Gly Arg Pro Pro Gly Glu Pro Gly Gly Pro Phe Cys 
        275                 280                 285             


Leu Glu Gly Pro Asp Gly Ser Tyr Arg Asp Leu Ser Phe Lys Gly Arg 
    290                 295                 300                 


Ser Gly Gly Ser Glu Gly Arg Cys Leu Ala Cys Thr Gly Met Ser Met 
305                 310                 315                 320 


Ser Leu Asp Gly Gln Ser Val Lys Arg Ser Ala Trp His Thr Met Met 
                325                 330                 335     


Val Ser Gln Gly Arg Asp Gly Tyr Pro Gly Ala Gly Pro Gly Lys Gly 
            340                 345                 350         


Leu Leu Gly Pro Glu Thr Lys Ala Lys Ala Arg Thr Tyr His Tyr Leu 
        355                 360                 365             


Gln Val Pro Gln Asp Asp Trp Gly Gly Tyr Pro Thr Gly Gly Lys Asp 
    370                 375                 380                 


Gly Glu Ile Pro Cys Arg Arg Met Arg Ser Gly Ser Tyr Ile Lys Ala 
385                 390                 395                 400 


Met Gly Asp Glu Glu Ser Gly Asp Ser Asp Gly Ser Pro Lys Thr Ser 
                405                 410                 415     


Pro Lys Ala Val Ala Arg Arg Phe Thr Thr Arg Arg Ser Ser Ser Val 
            420                 425                 430         


Asp Gln Ala Arg Ile Asn Cys Cys Val Pro Pro Arg Ile His Pro Arg 
        435                 440                 445             


Ser Ser Ile Pro Gly Tyr Ser Arg Ser Leu Thr Thr Gly Gln Leu Ser 
    450                 455                 460                 


Asp Glu Leu Asn Gln Gln Leu Glu Ala Val Cys Gly Ser Val Phe Gly 
465                 470                 475                 480 


Glu Leu Glu Ser Gln Ala Val Asp Ala Leu Asp Leu Pro Gly Cys Phe 
                485                 490                 495     


Arg Met Arg Ser His Ser Tyr Leu Arg Ala Ile Gln Ala Gly Cys Ser 
            500                 505                 510         


Gln Asp Asp Asp Cys Leu Pro Leu Leu Ala Thr Pro Ala Ala Val Ser 
        515                 520                 525             


Gly Arg Pro Gly Ser Ser Phe Asn Phe Arg Lys Ala Pro Pro Pro Ile 
    530                 535                 540                 


Pro Pro Gly Ser Gln Ala Pro Pro Arg Ile Ser Ile Thr Ala Gln Ser 
545                 550                 555                 560 


Ser Thr Asp Ser Ala His Glu Ser Phe Thr Ala Ala Glu Gly Pro Ala 
                565                 570                 575     


Arg Arg Cys Ser Ser Ala Asp Gly Leu Asp Gly Pro Ala Met Gly Ala 
            580                 585                 590         


Arg Thr Leu Glu Leu Ala Pro Val Pro Pro Arg Ala Ser Pro Lys Pro 
        595                 600                 605             


Pro Thr Leu Ile Ile Lys Thr Ile Pro Gly Arg Glu Glu Leu Arg Ser 
    610                 615                 620                 


Leu Ala Arg Gln Arg Lys Trp Arg Pro Ser Ile Gly Val Gln Val Glu 
625                 630                 635                 640 


Thr Ile Ser Asp Ser Asp Thr Glu Asn Arg Ser Arg Arg Glu Phe His 
                645                 650                 655     


Ser Ile Gly Val Gln Val Glu Glu Asp Lys Arg Arg Ala Arg Phe Lys 
            660                 665                 670         


Arg Ser Asn Ser Val Thr Ala Gly Val Gln Ala Asp Leu Glu Leu Glu 
        675                 680                 685             


Gly Leu Ala Gly Leu Ala Thr Val Ala Thr Glu Asp Lys Ala Leu Gln 
    690                 695                 700                 


Phe Gly Arg Ser Phe Gln Arg His Ala Ser Glu Pro Gln Pro Gly Pro 
705                 710                 715                 720 


Arg Ala Pro Thr Tyr Ser Val Phe Arg Thr Val His Thr Gln Gly Gln 
                725                 730                 735     


Trp Ala Tyr Arg Glu Gly Tyr Pro Leu Pro Tyr Glu Pro Pro Ala Thr 
            740                 745                 750         


Asp Gly Ser Pro Gly Pro Ala Pro Ala Pro Thr Pro Gly Pro Gly Ala 
        755                 760                 765             


Gly Arg Arg Asp Ser Trp Ile Glu Arg Gly Ser Arg Ser Leu Pro Asp 
    770                 775                 780                 


Ser Gly Arg Ala Ser Pro Cys Pro Arg Asp Gly Glu Trp Phe Ile Lys 
785                 790                 795                 800 


Met Leu Arg Ala Glu Val Glu Lys Leu Glu His Trp Cys Gln Gln Met 
                805                 810                 815     


Glu Arg Glu Ala Glu Asp Tyr Glu Leu Pro Glu Glu Ile Leu Glu Lys 
            820                 825                 830         


Ile Arg Ser Ala Val Gly Ser Thr Gln Leu Leu Leu Ser Gln Lys Val 
        835                 840                 845             


Gln Gln Phe Phe Arg Leu Cys Gln Gln Ser Met Asp Pro Thr Ala Phe 
    850                 855                 860                 


Pro Val Pro Thr Phe Gln Asp Leu Ala Gly Phe Trp Asp Leu Leu Gln 
865                 870                 875                 880 


Leu Ser Ile Glu Asp Val Thr Leu Lys Phe Leu Glu Leu Gln Gln Leu 
                885                 890                 895     


Lys Ala Asn Ser Trp Lys Leu Leu Glu Pro Lys Glu Glu Lys Lys Val 
            900                 905                 910         


Pro Pro Pro Ile Pro Lys Lys Pro Leu Arg Gly Arg Gly Val Pro Val 
        915                 920                 925             


Lys Glu Arg Ser Leu Asp Ser Val Asp Arg Gln Arg Gln Glu Ala Arg 
    930                 935                 940                 


Lys Arg Leu Leu Ala Ala Lys Arg Ala Ala Ser Phe Arg His Ser Ser 
945                 950                 955                 960 


Ala Thr Glu Ser Ala Asp Ser Ile Glu Ile Tyr Ile Pro Glu Ala Gln 
                965                 970                 975     


Thr Arg Leu 
            


<210>  113
<211>  3105
<212>  DNA
<213>  Homosapiens

<400>  113
cggtgccagg tgggctacgc ggctggggcg gctgcggata tcgccttagg gacgcgttga     60

cattcactgg ctagtccacc gctctcagtc ggagaccaca ttgcctcgtg tccaactatc    120

cattaccaag aagaaatcta ttcgtttgag cctgagacac tctttgaggt aaaaaattag    180

aatgaaagaa cctttggatg gtgaatgtgg caaagcagtg gtaccacagc aggagcttct    240

ggacaaaatt aaagaagaac cagacaatgc tcaagagtat ggatgtgtcc aacagccaaa    300

aactcaagaa agtaaattga aaattggtgg tgtgtcttca gttaatgaga gacctattgc    360

ccagcagttg aacccaggct ttcagctttc ttttgcatca tctggcccaa gtgtgttgct    420

tccttcagtt ccagctgttg ctattaaggt tttttgttct ggttgtaaaa aaatgcttta    480

taagggccaa actgcatatc ataagacagg atctactcag ctcttctgct ccacacgatg    540

catcaccaga cattcttcac ctgcctgcct gccacctcct cccaagaaaa cctgcacaaa    600

ctgctcgaaa gacattttaa atcctaagga tgtgatcaca actcgctttg agaattccta    660

tcctagcaaa gatttctgca gccaatcatg cttgtcatct tatgagctaa agaaaaaacc    720

tgttgttacc atatatacca aaagcatttc aactaagtgc agtatgtgtc agaagaatgc    780

tgatactcga tttgaagtta aatatcaaaa tgtggtacat ggtctttgta gtgatgcctg    840

tttttcaaaa tttcactcta caaacaacct caccatgaac tgttgtgaga actgtgggag    900

ctattgctat agtagctctg gtccttgcca atcccagaag gtttttagtt caacaagtgt    960

cacggcatac aagcagaatt ctgcccaaat tcctccatat gccctgggga agtcattgag   1020

gccctcagct gaaatgattg agactacaaa tgattcagga aaaacagagc ttttctgctc   1080

tattaattgc ttatctgctt acagagttaa gactgttact tcttcaggtg tccaggtttc   1140

atgtcatagt tgtaaaacct cagcaatccc tcagtatcac ctagccatgt caaatggaac   1200

tatatacagc ttctgcagct ccagttgtgt ggttgctttc cagaatgtat ttagcaagcc   1260

aaaaggaaca aactcttcgg cggtgcccct gtctcagggc caagtggttg taagcccgcc   1320

ctcctccagg tcagcagtgt caataggagg aggtaacacc tctgccgttt cccccagctc   1380

catccgtggc tctgctgcag ccagcctcca acctcttgct gaacaatccc agcaagttgc   1440

tttaacccat acagttgtta aactcaagtg tcagcactgt aaccatctat ttgccacaaa   1500

accagaactt cttttttaca agggtaaaat gtttctgttt tgtggcaaga attgctctga   1560

tgaatacaag aagaaaaata aagttgtggc aatgtgtgac tactgtaaac tgcagaaaat   1620

tataaaggag actgtgcgat tctcaggggt tgataagcca ttctgtagtg aagtttgcaa   1680

attcctctct gcccgtgact ttggagaacg atggggaaac tactgtaaga tgtgcagcta   1740

ctgttcacag acatccccaa atttggtaga aaatcgattg gagggcaagt tagaagagtt   1800

ttgttgtgaa gattgtatgt ccaaatttac agttctgttt tatcagatgg ccaagtgtga   1860

tggttgtaaa cgacagggta aactaagcga gtccataaag tggcgaggca acattaaaca   1920

tttctgtaac ctattttgtg tcttggagtt ttgtcatcag caaattatga atgactgtct   1980

tccacaaaat aaagtaaata tttctaaagc aaaaactgct gtgacggagc tcccttctgc   2040

aaggacagat acaacaccag ttataaccag tgtgatgtca ttggcaaaaa tacctgctac   2100

cttatctaca gggaacacta acagtgtttt aaaaggtgca gttactaaag aggcagcaaa   2160

gatcattcaa gatgaaagta cacaggaaga tgctatgaaa tttccatctt cccaatcttc   2220

ccagccttcc aggcttttaa agaacaaagg catatcatgc aaacccgtca cacagaccaa   2280

ggccacttct tgcaaaccac atacacagca caaagaatgt cagacagaat gccctgttcg   2340

tgcagtttgc tgaggtgttc ccgctgaagg tatttggcta ccagccagat cccctgaact   2400

accaaatagc tgtgggcttt ctggaactgc tggctgggtt gctgctggtc atgggcccac   2460

cgatgctgca agagatcagt aacttgttct tgattctgct catgatgggg gctatcttca   2520

ccttggcagc tctgaaagag tcactaagca cctgtatccc agccattgtc tgcctggggt   2580

tcctgctgct gctgaatgtc ggccagctct tagcccagac taagaaggtg gtcagaccca   2640

ctaggaagaa gactctaagt acattcaagg aatcctggaa gtagagcatc tctgtctctt   2700

tatgccatgc agctgtcaca gcaggaacat ggtagaacac agagtctatc atcttgttac   2760

cagtataata tccagggtca gccagtgttg aaagagacat tttgtctacc tggcactgct   2820

ttctcttttt agctttacta ctcttttgtg aggagtacat gttatgcata ttaacattcc   2880

tcatgtcata tgaaaataca aaataagcag aaaagaaatt taaatcaacc aaaattctga   2940

tgccccaaat aaccactttt aatgccttgg tgtaagtata cctctgaact tttttctgtg   3000

cctttaaaca gatatatatt ttttttaaat gaaaataaaa ccatatatcc tattttattt   3060

cctcctttta aaaccttata aactataaca ctgttaaaaa aaaaa                   3105


<210>  114
<211>  723
<212>  PRT
<213>  Homosapiens

<400>  114

Met Lys Glu Pro Leu Asp Gly Glu Cys Gly Lys Ala Val Val Pro Gln 
1               5                   10                  15      


Gln Glu Leu Leu Asp Lys Ile Lys Glu Glu Pro Asp Asn Ala Gln Glu 
            20                  25                  30          


Tyr Gly Cys Val Gln Gln Pro Lys Thr Gln Glu Ser Lys Leu Lys Ile 
        35                  40                  45              


Gly Gly Val Ser Ser Val Asn Glu Arg Pro Ile Ala Gln Gln Leu Asn 
    50                  55                  60                  


Pro Gly Phe Gln Leu Ser Phe Ala Ser Ser Gly Pro Ser Val Leu Leu 
65                  70                  75                  80  


Pro Ser Val Pro Ala Val Ala Ile Lys Val Phe Cys Ser Gly Cys Lys 
                85                  90                  95      


Lys Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr 
            100                 105                 110         


Gln Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala 
        115                 120                 125             


Cys Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Asp 
    130                 135                 140                 


Ile Leu Asn Pro Lys Asp Val Ile Thr Thr Arg Phe Glu Asn Ser Tyr 
145                 150                 155                 160 


Pro Ser Lys Asp Phe Cys Ser Gln Ser Cys Leu Ser Ser Tyr Glu Leu 
                165                 170                 175     


Lys Lys Lys Pro Val Val Thr Ile Tyr Thr Lys Ser Ile Ser Thr Lys 
            180                 185                 190         


Cys Ser Met Cys Gln Lys Asn Ala Asp Thr Arg Phe Glu Val Lys Tyr 
        195                 200                 205             


Gln Asn Val Val His Gly Leu Cys Ser Asp Ala Cys Phe Ser Lys Phe 
    210                 215                 220                 


His Ser Thr Asn Asn Leu Thr Met Asn Cys Cys Glu Asn Cys Gly Ser 
225                 230                 235                 240 


Tyr Cys Tyr Ser Ser Ser Gly Pro Cys Gln Ser Gln Lys Val Phe Ser 
                245                 250                 255     


Ser Thr Ser Val Thr Ala Tyr Lys Gln Asn Ser Ala Gln Ile Pro Pro 
            260                 265                 270         


Tyr Ala Leu Gly Lys Ser Leu Arg Pro Ser Ala Glu Met Ile Glu Thr 
        275                 280                 285             


Thr Asn Asp Ser Gly Lys Thr Glu Leu Phe Cys Ser Ile Asn Cys Leu 
    290                 295                 300                 


Ser Ala Tyr Arg Val Lys Thr Val Thr Ser Ser Gly Val Gln Val Ser 
305                 310                 315                 320 


Cys His Ser Cys Lys Thr Ser Ala Ile Pro Gln Tyr His Leu Ala Met 
                325                 330                 335     


Ser Asn Gly Thr Ile Tyr Ser Phe Cys Ser Ser Ser Cys Val Val Ala 
            340                 345                 350         


Phe Gln Asn Val Phe Ser Lys Pro Lys Gly Thr Asn Ser Ser Ala Val 
        355                 360                 365             


Pro Leu Ser Gln Gly Gln Val Val Val Ser Pro Pro Ser Ser Arg Ser 
    370                 375                 380                 


Ala Val Ser Ile Gly Gly Gly Asn Thr Ser Ala Val Ser Pro Ser Ser 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ala Ala Ser Leu Gln Pro Leu Ala Glu Gln Ser 
                405                 410                 415     


Gln Gln Val Ala Leu Thr His Thr Val Val Lys Leu Lys Cys Gln His 
            420                 425                 430         


Cys Asn His Leu Phe Ala Thr Lys Pro Glu Leu Leu Phe Tyr Lys Gly 
        435                 440                 445             


Lys Met Phe Leu Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys Lys 
    450                 455                 460                 


Lys Asn Lys Val Val Ala Met Cys Asp Tyr Cys Lys Leu Gln Lys Ile 
465                 470                 475                 480 


Ile Lys Glu Thr Val Arg Phe Ser Gly Val Asp Lys Pro Phe Cys Ser 
                485                 490                 495     


Glu Val Cys Lys Phe Leu Ser Ala Arg Asp Phe Gly Glu Arg Trp Gly 
            500                 505                 510         


Asn Tyr Cys Lys Met Cys Ser Tyr Cys Ser Gln Thr Ser Pro Asn Leu 
        515                 520                 525             


Val Glu Asn Arg Leu Glu Gly Lys Leu Glu Glu Phe Cys Cys Glu Asp 
    530                 535                 540                 


Cys Met Ser Lys Phe Thr Val Leu Phe Tyr Gln Met Ala Lys Cys Asp 
545                 550                 555                 560 


Gly Cys Lys Arg Gln Gly Lys Leu Ser Glu Ser Ile Lys Trp Arg Gly 
                565                 570                 575     


Asn Ile Lys His Phe Cys Asn Leu Phe Cys Val Leu Glu Phe Cys His 
            580                 585                 590         


Gln Gln Ile Met Asn Asp Cys Leu Pro Gln Asn Lys Val Asn Ile Ser 
        595                 600                 605             


Lys Ala Lys Thr Ala Val Thr Glu Leu Pro Ser Ala Arg Thr Asp Thr 
    610                 615                 620                 


Thr Pro Val Ile Thr Ser Val Met Ser Leu Ala Lys Ile Pro Ala Thr 
625                 630                 635                 640 


Leu Ser Thr Gly Asn Thr Asn Ser Val Leu Lys Gly Ala Val Thr Lys 
                645                 650                 655     


Glu Ala Ala Lys Ile Ile Gln Asp Glu Ser Thr Gln Glu Asp Ala Met 
            660                 665                 670         


Lys Phe Pro Ser Ser Gln Ser Ser Gln Pro Ser Arg Leu Leu Lys Asn 
        675                 680                 685             


Lys Gly Ile Ser Cys Lys Pro Val Thr Gln Thr Lys Ala Thr Ser Cys 
    690                 695                 700                 


Lys Pro His Thr Gln His Lys Glu Cys Gln Thr Glu Cys Pro Val Arg 
705                 710                 715                 720 


Ala Val Cys 
            


<210>  115
<211>  4250
<212>  DNA
<213>  Homosapiens

<400>  115
agcgtggctt cgaagattgt ttcagaagcg ttgggcggcg ggcgtccctg agagaaatta     60

gttcaagcga ttctcgtgcc tcagcctccc gagtagctgg gattacagga atctggaaac    120

tgttcttcag gaagaaacca attagtttgg aactggagaa ttcctttgca tcagatacta    180

aaatgaaaga accactttta ggtggtgagt gtgacaaggc agtggcatca cagctggggc    240

tgctagatga aattaagaca gaacccgaca atgctcaaga gtattgtcat aggcaacagt    300

ccagaactca ggagaatgaa ctgaaaataa atgctgtgtt ttcagagagt gcttcacagt    360

tgactgcagg cattcagctt tctctggcat catctggcgt gaataaaatg cttccttcag    420

tttcaaccac agctattcag gtttcctgtg ctggttgtaa aaaaattctc cagaaggggc    480

aaactgctta tcagaggaaa ggatctgctc aacttttctg ctccatacca tgcatcactg    540

aatacatttc atctgccagt tcaccagttc cttctaagag aacttgttca aactgctcaa    600

aagacatttt aaatccaaag gatgtgatta gtgtccagct ggaagacact acctcttgca    660

aaactttttg cagcctatct tgtctttcat catatgaaga aaaaagaaaa ccatttgtta    720

ccatatgtac taatagcatt ttgaccaagt gcagcatgtg ccagaagact gctattattc    780

agtatgaagt aaaataccaa aatgtgaaac ataatctttg cagtaatgcc tgcctttcaa    840

agtttcactc tgctaacaac ttcatcatga actgctgtga gaactgtggc acttactgtt    900

acaccagctc tagtctgtcc cacatacttc agatggaagg acagtctcat tactttaata    960

gttcaaagag tattacagca tataagcaga aacctgccaa accacttata tctgttcctt   1020

gcaaaccatt gaagccctca gatgaaatga ttgagactac gagtgatttg gggaagacag   1080

agcttttctg ctctattaat tgtttctctg catacagtaa agctaagatg gaatcttctt   1140

cagtaagtgt tgtttctgtg gtgcatgata cttcaacaga gcttctttct ccaaagaaag   1200

atacgactcc agttataagc aatatagtgt cattggcaga caccgatgtt gccttgccca   1260

tcatgaacac tgatgtctta caagatacag tttcttcagt aacagcaaca gcagatgtca   1320

ttgtggatct ttctaagagt tcacctagtg aacccagtaa tgctgttgct agtagtagta   1380

cggaacagcc aagcgtttca ccatcttcat cagtattcag tcagcatgca attggttcca   1440

gtacagaagt acaaaaagac aatatgaaat ctatgaaaat aagtgatgaa ctatgtcacc   1500

caaaatgtac atccaaagta caaaaagtta aaggtaaatc acgaagtatt aaaaaatctt   1560

gttgtgcaga ttttgagtgt ttggaaaaca gtaaaaaaga tgtggcattc tgttattcat   1620

gccagttgtt ctgccaaaaa tattttagct gtggaagaga gtcatttgca acccacggaa   1680

cttctaattg gaaaaaaacc ctggaaaaat tcagaaagca tgaaaaaagt gaaatgcatt   1740

tgaagtcatt ggaattttgg agagaatacc aattttgtga tggagctgtc agtgacgatt   1800

tatctattca ttcgaaacag attgagggaa ataaaaagta cctaaagctt ataattgaaa   1860

atattttatt tcttggaaag cagtgtttac ccttaagagg aaacgaccag tcagtttcat   1920

ctgtgaataa aggcaatttt ttagaattgt tagaaatgag agcaaaagat aaaggagaag   1980

aaacatttcg acttatgaat tcacaagttg acttctataa cagtacacaa attcaaagtg   2040

atattatcga aataataaag actgaaatgt tgcaggatat tgtgaatgag atcaatgact   2100

cctcagcatt ttcaatcata tgtgatgaga caatcaatag tgccatgaaa gaacagcttt   2160

caatttgtgt aagataccca caaaaatcat caaaggctat cttaattaag gaaagattct   2220

tgggttttgt tgatactgag gagatgactg ggacccactt acataggact atcaaaactt   2280

atctgcagca aattggagtt gatatggata aaatacatgg ccaggcctat gatagcacca   2340

ctaatttgaa gataaaattt aataaaatag cagcagaatt caagaaagaa gaaccaagag   2400

ctttatacat acattgttat gcacactttt tggatttatc aataattagg ttttgtaaag   2460

aagtaaaaga actccgaagt gctctaaaaa ctctcagttc tttgttcaac actatttgta   2520

tgtctgggga aatgttggca aattttcgaa acatttatag gctaagtcaa aacaaaacat   2580

gcaagaaaca tatatcacaa tcatgttgga cagtccatga tcgtacatta ctatctgtga   2640

ttgacagtct tccagagatt attgaaacat tggaagttat agcaagccat tcttcaaata   2700

caagtttcgc cgatgaattg agtcatttgc tgacattggt ttccaaattt gaatttgtct   2760

tttgtttgaa attcctgtat cgagtgctga gtgttacagg aattctttcc aaagagcttc   2820

aaaataaaac catagacatt ttttctttgt cttcaaaaat agaagcaatt ttggaatgtt   2880

ttatcatctg aaagaaatga cgtatacttt aaaacaatct gggatggaac agaggaaata   2940

tgtcaaaaaa taacctgtaa aggttttaaa gttgaaaaac cttctcttca gaaaagaaga   3000

aaaattcaga aatcagtaga tcttggcaat tcagataata tgttttttcc tacttcaaca   3060

gaagaacaat ataaaattaa tatctattac caaggattag atactatatt acaaaattta   3120

aagttatgtt tttcggagtt tgattattgc aaaataaagc aaatttcaga actgttattt   3180

aaatggaatg aaccattaaa tgaaacaaca gcaaaacatg ttcaggaatt ttataaactt   3240

gatgaggaca ttatcccaga acttagattt tatcgacatt atgcaaagct taactttgtc   3300

atagatgata gttgcataaa cttcgtcagt ctcggctgtt tgtttattca gcatggtctt   3360

cacagtaata ttccttgtct ctcaaagcta ttatatattg ctttgtcttg gccaattact   3420

tcagcaagta ctgagaactc attttctacc ctgcctcgtc ttaagacata tttatgtaat   3480

accatgggac aagagaagct tactggccca gccctaatgg ctgttgagca ggagttggta   3540

aataaactaa tggagcctga aagactcaat gaaattgtgg aaaagtttat cagtcagatg   3600

aaagaaatat aatacatgct catttgaact tacctaaaag acttgtattt ccattgggat   3660

gttttcattt caaaattgtt caaaattcaa aagacacaga acgataaaca gtgaagtctc   3720

cttccctcct ttagaactca ttttctcttc ccaaaaagtg ttatcttttc cttaaatatc   3780

cctctagagg tatttttcct aagtggtatt gtacggtgta tactgttctt cagcttgtct   3840

tctctgtgta acatattttt gagattgtcc catgtcgtta catgaagagt ttcttgattc   3900

ttggtctata attgcagatg ttattgtatg aatgtaccat aatatatttg agcagtccct   3960

gctgacattt ttttcctaac cttttgctat tataaataat gattcatttt ataacctttt   4020

atataggtca cattgcacat gagtgagttt actgtaagct ggaaatctaa agttagaatt   4080

actaggttaa gatatgtgca tttttacttt tgatagatat tggcaagttg ccatctataa   4140

ggattgtgcc agtttacagt cccacccaca atgcatgaga gtgcctatta aatctttgta   4200

agtgttaaaa aaaaaaaaaa aaaaaaaaaa aaaaataaaa aaaaaaaaaa              4250


<210>  116
<211>  902
<212>  PRT
<213>  Homosapiens

<400>  116

Met Lys Glu Pro Leu Leu Gly Gly Glu Cys Asp Lys Ala Val Ala Ser 
1               5                   10                  15      


Gln Leu Gly Leu Leu Asp Glu Ile Lys Thr Glu Pro Asp Asn Ala Gln 
            20                  25                  30          


Glu Tyr Cys His Arg Gln Gln Ser Arg Thr Gln Glu Asn Glu Leu Lys 
        35                  40                  45              


Ile Asn Ala Val Phe Ser Glu Ser Ala Ser Gln Leu Thr Ala Gly Ile 
    50                  55                  60                  


Gln Leu Ser Leu Ala Ser Ser Gly Val Asn Lys Met Leu Pro Ser Val 
65                  70                  75                  80  


Ser Thr Thr Ala Ile Gln Val Ser Cys Ala Gly Cys Lys Lys Ile Leu 
                85                  90                  95      


Gln Lys Gly Gln Thr Ala Tyr Gln Arg Lys Gly Ser Ala Gln Leu Phe 
            100                 105                 110         


Cys Ser Ile Pro Cys Ile Thr Glu Tyr Ile Ser Ser Ala Ser Ser Pro 
        115                 120                 125             


Val Pro Ser Lys Arg Thr Cys Ser Asn Cys Ser Lys Asp Ile Leu Asn 
    130                 135                 140                 


Pro Lys Asp Val Ile Ser Val Gln Leu Glu Asp Thr Thr Ser Cys Lys 
145                 150                 155                 160 


Thr Phe Cys Ser Leu Ser Cys Leu Ser Ser Tyr Glu Glu Lys Arg Lys 
                165                 170                 175     


Pro Phe Val Thr Ile Cys Thr Asn Ser Ile Leu Thr Lys Cys Ser Met 
            180                 185                 190         


Cys Gln Lys Thr Ala Ile Ile Gln Tyr Glu Val Lys Tyr Gln Asn Val 
        195                 200                 205             


Lys His Asn Leu Cys Ser Asn Ala Cys Leu Ser Lys Phe His Ser Ala 
    210                 215                 220                 


Asn Asn Phe Ile Met Asn Cys Cys Glu Asn Cys Gly Thr Tyr Cys Tyr 
225                 230                 235                 240 


Thr Ser Ser Ser Leu Ser His Ile Leu Gln Met Glu Gly Gln Ser His 
                245                 250                 255     


Tyr Phe Asn Ser Ser Lys Ser Ile Thr Ala Tyr Lys Gln Lys Pro Ala 
            260                 265                 270         


Lys Pro Leu Ile Ser Val Pro Cys Lys Pro Leu Lys Pro Ser Asp Glu 
        275                 280                 285             


Met Ile Glu Thr Thr Ser Asp Leu Gly Lys Thr Glu Leu Phe Cys Ser 
    290                 295                 300                 


Ile Asn Cys Phe Ser Ala Tyr Ser Lys Ala Lys Met Glu Ser Ser Ser 
305                 310                 315                 320 


Val Ser Val Val Ser Val Val His Asp Thr Ser Thr Glu Leu Leu Ser 
                325                 330                 335     


Pro Lys Lys Asp Thr Thr Pro Val Ile Ser Asn Ile Val Ser Leu Ala 
            340                 345                 350         


Asp Thr Asp Val Ala Leu Pro Ile Met Asn Thr Asp Val Leu Gln Asp 
        355                 360                 365             


Thr Val Ser Ser Val Thr Ala Thr Ala Asp Val Ile Val Asp Leu Ser 
    370                 375                 380                 


Lys Ser Ser Pro Ser Glu Pro Ser Asn Ala Val Ala Ser Ser Ser Thr 
385                 390                 395                 400 


Glu Gln Pro Ser Val Ser Pro Ser Ser Ser Val Phe Ser Gln His Ala 
                405                 410                 415     


Ile Gly Ser Ser Thr Glu Val Gln Lys Asp Asn Met Lys Ser Met Lys 
            420                 425                 430         


Ile Ser Asp Glu Leu Cys His Pro Lys Cys Thr Ser Lys Val Gln Lys 
        435                 440                 445             


Val Lys Gly Lys Ser Arg Ser Ile Lys Lys Ser Cys Cys Ala Asp Phe 
    450                 455                 460                 


Glu Cys Leu Glu Asn Ser Lys Lys Asp Val Ala Phe Cys Tyr Ser Cys 
465                 470                 475                 480 


Gln Leu Phe Cys Gln Lys Tyr Phe Ser Cys Gly Arg Glu Ser Phe Ala 
                485                 490                 495     


Thr His Gly Thr Ser Asn Trp Lys Lys Thr Leu Glu Lys Phe Arg Lys 
            500                 505                 510         


His Glu Lys Ser Glu Met His Leu Lys Ser Leu Glu Phe Trp Arg Glu 
        515                 520                 525             


Tyr Gln Phe Cys Asp Gly Ala Val Ser Asp Asp Leu Ser Ile His Ser 
    530                 535                 540                 


Lys Gln Ile Glu Gly Asn Lys Lys Tyr Leu Lys Leu Ile Ile Glu Asn 
545                 550                 555                 560 


Ile Leu Phe Leu Gly Lys Gln Cys Leu Pro Leu Arg Gly Asn Asp Gln 
                565                 570                 575     


Ser Val Ser Ser Val Asn Lys Gly Asn Phe Leu Glu Leu Leu Glu Met 
            580                 585                 590         


Arg Ala Lys Asp Lys Gly Glu Glu Thr Phe Arg Leu Met Asn Ser Gln 
        595                 600                 605             


Val Asp Phe Tyr Asn Ser Thr Gln Ile Gln Ser Asp Ile Ile Glu Ile 
    610                 615                 620                 


Ile Lys Thr Glu Met Leu Gln Asp Ile Val Asn Glu Ile Asn Asp Ser 
625                 630                 635                 640 


Ser Ala Phe Ser Ile Ile Cys Asp Glu Thr Ile Asn Ser Ala Met Lys 
                645                 650                 655     


Glu Gln Leu Ser Ile Cys Val Arg Tyr Pro Gln Lys Ser Ser Lys Ala 
            660                 665                 670         


Ile Leu Ile Lys Glu Arg Phe Leu Gly Phe Val Asp Thr Glu Glu Met 
        675                 680                 685             


Thr Gly Thr His Leu His Arg Thr Ile Lys Thr Tyr Leu Gln Gln Ile 
    690                 695                 700                 


Gly Val Asp Met Asp Lys Ile His Gly Gln Ala Tyr Asp Ser Thr Thr 
705                 710                 715                 720 


Asn Leu Lys Ile Lys Phe Asn Lys Ile Ala Ala Glu Phe Lys Lys Glu 
                725                 730                 735     


Glu Pro Arg Ala Leu Tyr Ile His Cys Tyr Ala His Phe Leu Asp Leu 
            740                 745                 750         


Ser Ile Ile Arg Phe Cys Lys Glu Val Lys Glu Leu Arg Ser Ala Leu 
        755                 760                 765             


Lys Thr Leu Ser Ser Leu Phe Asn Thr Ile Cys Met Ser Gly Glu Met 
    770                 775                 780                 


Leu Ala Asn Phe Arg Asn Ile Tyr Arg Leu Ser Gln Asn Lys Thr Cys 
785                 790                 795                 800 


Lys Lys His Ile Ser Gln Ser Cys Trp Thr Val His Asp Arg Thr Leu 
                805                 810                 815     


Leu Ser Val Ile Asp Ser Leu Pro Glu Ile Ile Glu Thr Leu Glu Val 
            820                 825                 830         


Ile Ala Ser His Ser Ser Asn Thr Ser Phe Ala Asp Glu Leu Ser His 
        835                 840                 845             


Leu Leu Thr Leu Val Ser Lys Phe Glu Phe Val Phe Cys Leu Lys Phe 
    850                 855                 860                 


Leu Tyr Arg Val Leu Ser Val Thr Gly Ile Leu Ser Lys Glu Leu Gln 
865                 870                 875                 880 


Asn Lys Thr Ile Asp Ile Phe Ser Leu Ser Ser Lys Ile Glu Ala Ile 
                885                 890                 895     


Leu Glu Cys Phe Ile Ile 
            900         


<210>  117
<211>  3071
<212>  DNA
<213>  Homosapiens

<400>  117
ccgccatttt gtgagaagca aggtggcctc cacgtttcct gagcgtcttc ttcgcttttg     60

cctcgaccgc cccttgacca cagacatgtc tcgggatcgg ttccggagtc gtggcggtgg    120

cggtggtggc ttccacaggc gtggaggagg cggcggccgc ggcggcctcc acgacttccg    180

ttctccgccg cccggcatgg gcctcaatca gaatcgcggc cccatgggtc ctggcccggg    240

ccagagcggc cctaagcctc cgatcccgcc accgcctcca caccaacagc agcaacagcc    300

accaccgcag cagccaccgc cgcagcagcc gccaccgcat cagccgccgc cgcatccaca    360

gccgcatcag cagcagcagc cgccgccacc gccgcaggac tcttccaagc ccgtcgttgc    420

tcagggaccc ggccccgctc ccggagtagg cagcgcacca ccagcctcca gctcggcccc    480

gcccgccact ccaccaacct cgggggcccc gccagggtcc gggccaggcc cgactccgac    540

cccgccgcct gcagtcacct cggcccctcc cggggcgccg ccacccaccc cgccaagcag    600

cggggtccct accacacctc ctcaggccgg aggcccgccg cctccgcccg cggcagtccc    660

gggcccgggt ccagggccta agcagggccc aggtccgggt ggtcccaaag gcggcaaaat    720

gcctggcggg ccgaagccag gtggcggccc gggcctaagt acgcctggcg gccaccccaa    780

gccgccgcat cgaggcggcg gggagccccg cgggggccgc cagcaccacc cgccctacca    840

ccagcagcat caccaggggc ccccgcccgg cgggcccggc ggccgcagcg aggagaagat    900

ctcggactcg gaggggttta aagccaattt gtctctcttg aggaggcctg gagagaaaac    960

ttacacacag cgatgtcggt tgtttgttgg gaatctacct gctgatatca cggaggatga   1020

attcaaaaga ctatttgcta aatatggaga accaggagaa gtttttatca acaaaggcaa   1080

aggattcgga tttattaagc ttgaatctag agctttggct gaaattgcca aagccgaact   1140

ggatgataca cccatgagag gtagacagct tcgagttcgc tttgccacac atgctgctgc   1200

cctttctgtt cgtaatcttt caccttatgt ttccaatgaa ctgttggaag aagcctttag   1260

ccaatttggt cctattgaaa gggctgttgt aatagtggat gatcgtggaa gatctacagg   1320

gaaaggcatt gttgaatttg cttctaagcc agcagcaaga aaggcatttg aacgatgcag   1380

tgaaggtgtt ttcttactga cgacaactcc tcgtccagtc attgtggaac cacttgaaca   1440

actagatgat gaagatggtc ttcctgaaaa acttgcccag aagaatccaa tgtatcaaaa   1500

ggagagagaa acccctcctc gttttgccca gcatggcacg tttgagtacg aatattctca   1560

gcgatggaag tctttggatg aaatggaaaa acagcaaagg gaacaagttg aaaaaaacat   1620

gaaagatgca aaagacaaat tggaaagtga aatggaagat gcctatcatg aacatcaggc   1680

aaatcttttg cgccaagatc tgatgagacg acaggaagaa ttaagacgca tggaagaact   1740

tcacaatcaa gaaatgcaga aacgtaaaga aatgcaattg aggcaagagg aggaacgacg   1800

tagaagagag gaagagatga tgattcgtca acgtgagatg gaagaacaaa tgaggcgcca   1860

aagagaggaa agttacagcc gaatgggcta catggatcca cgggaaagag acatgcgaat   1920

gggtggcgga ggagcaatga acatgggaga tccctatggt tcaggaggcc agaaatttcc   1980

acctctagga ggtggtggtg gcataggtta tgaagctaat cctggcgttc caccagcaac   2040

catgagtggt tccatgatgg gaagtgacat gcgtactgag cgctttgggc agggaggtgc   2100

ggggcctgtg ggtggacagg gtcctagagg aatggggcct ggaactccag caggatatgg   2160

tagagggaga gaagagtacg aaggcccaaa caaaaaaccc cgattttaga tgtgatattt   2220

aggctttcat tccagtttgt tttgtttttt tgtttagata ccaatctttt aaattcttgc   2280

attttagtaa gaaagctatc tttttatgga tgttagcagt ttattgacct aatatttgta   2340

aatggtctgt ttgggcaggt aaaattatgt aatgcagtgt ttggaacagg agaatttttt   2400

tttccttttt atttctttat tttttctttt ttactgtata atgtccctca agtttatggc   2460

agtgtacctt gtgccactga atttccaaag tgtaccaatt tttttttttt tactgtgctt   2520

caaataaata gaaaaatagt tataatattg gatcttcaac tttgccattc atgcttctat   2580

gcatattagg ctacgtattc cacattgaaa gcatgagagt gtctaggcct ttgaatggca   2640

tatgccattt ctgggaaatg catctggagg ctaagtattg ctttctacaa ataattgccc   2700

cctttgtttt aaaaagaaga aatgcatatt gaagtagttt gatgatttgt ttggcatata   2760

ggaagcacgc tggtgctaag tattttttaa atggttatgt aagcaaagct gaactgtaaa   2820

tcttcaggaa tatgtattaa gattgtggaa tgggtgtaag acaattggta gggggtgaaa   2880

gtgggtttga ttaaatggat cttttatggc cctatgatct atcctttact tgaaagcttt   2940

tgaaaagtgg aaaggtcatt ttgttgcatt tccccatttc ttgtttttaa aagaccaaca   3000

aatctcaagc cctataaatg gcttgtattg aacttttaca tttgaattaa agatgttaaa   3060

catgaaaaaa a                                                        3071


<210>  118
<211>  707
<212>  PRT
<213>  Homosapiens

<400>  118

Met Ser Arg Asp Arg Phe Arg Ser Arg Gly Gly Gly Gly Gly Gly Phe 
1               5                   10                  15      


His Arg Arg Gly Gly Gly Gly Gly Arg Gly Gly Leu His Asp Phe Arg 
            20                  25                  30          


Ser Pro Pro Pro Gly Met Gly Leu Asn Gln Asn Arg Gly Pro Met Gly 
        35                  40                  45              


Pro Gly Pro Gly Gln Ser Gly Pro Lys Pro Pro Ile Pro Pro Pro Pro 
    50                  55                  60                  


Pro His Gln Gln Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Gln 
65                  70                  75                  80  


Gln Pro Pro Pro His Gln Pro Pro Pro His Pro Gln Pro His Gln Gln 
                85                  90                  95      


Gln Gln Pro Pro Pro Pro Pro Gln Asp Ser Ser Lys Pro Val Val Ala 
            100                 105                 110         


Gln Gly Pro Gly Pro Ala Pro Gly Val Gly Ser Ala Pro Pro Ala Ser 
        115                 120                 125             


Ser Ser Ala Pro Pro Ala Thr Pro Pro Thr Ser Gly Ala Pro Pro Gly 
    130                 135                 140                 


Ser Gly Pro Gly Pro Thr Pro Thr Pro Pro Pro Ala Val Thr Ser Ala 
145                 150                 155                 160 


Pro Pro Gly Ala Pro Pro Pro Thr Pro Pro Ser Ser Gly Val Pro Thr 
                165                 170                 175     


Thr Pro Pro Gln Ala Gly Gly Pro Pro Pro Pro Pro Ala Ala Val Pro 
            180                 185                 190         


Gly Pro Gly Pro Gly Pro Lys Gln Gly Pro Gly Pro Gly Gly Pro Lys 
        195                 200                 205             


Gly Gly Lys Met Pro Gly Gly Pro Lys Pro Gly Gly Gly Pro Gly Leu 
    210                 215                 220                 


Ser Thr Pro Gly Gly His Pro Lys Pro Pro His Arg Gly Gly Gly Glu 
225                 230                 235                 240 


Pro Arg Gly Gly Arg Gln His His Pro Pro Tyr His Gln Gln His His 
                245                 250                 255     


Gln Gly Pro Pro Pro Gly Gly Pro Gly Gly Arg Ser Glu Glu Lys Ile 
            260                 265                 270         


Ser Asp Ser Glu Gly Phe Lys Ala Asn Leu Ser Leu Leu Arg Arg Pro 
        275                 280                 285             


Gly Glu Lys Thr Tyr Thr Gln Arg Cys Arg Leu Phe Val Gly Asn Leu 
    290                 295                 300                 


Pro Ala Asp Ile Thr Glu Asp Glu Phe Lys Arg Leu Phe Ala Lys Tyr 
305                 310                 315                 320 


Gly Glu Pro Gly Glu Val Phe Ile Asn Lys Gly Lys Gly Phe Gly Phe 
                325                 330                 335     


Ile Lys Leu Glu Ser Arg Ala Leu Ala Glu Ile Ala Lys Ala Glu Leu 
            340                 345                 350         


Asp Asp Thr Pro Met Arg Gly Arg Gln Leu Arg Val Arg Phe Ala Thr 
        355                 360                 365             


His Ala Ala Ala Leu Ser Val Arg Asn Leu Ser Pro Tyr Val Ser Asn 
    370                 375                 380                 


Glu Leu Leu Glu Glu Ala Phe Ser Gln Phe Gly Pro Ile Glu Arg Ala 
385                 390                 395                 400 


Val Val Ile Val Asp Asp Arg Gly Arg Ser Thr Gly Lys Gly Ile Val 
                405                 410                 415     


Glu Phe Ala Ser Lys Pro Ala Ala Arg Lys Ala Phe Glu Arg Cys Ser 
            420                 425                 430         


Glu Gly Val Phe Leu Leu Thr Thr Thr Pro Arg Pro Val Ile Val Glu 
        435                 440                 445             


Pro Leu Glu Gln Leu Asp Asp Glu Asp Gly Leu Pro Glu Lys Leu Ala 
    450                 455                 460                 


Gln Lys Asn Pro Met Tyr Gln Lys Glu Arg Glu Thr Pro Pro Arg Phe 
465                 470                 475                 480 


Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr Ser Gln Arg Trp Lys Ser 
                485                 490                 495     


Leu Asp Glu Met Glu Lys Gln Gln Arg Glu Gln Val Glu Lys Asn Met 
            500                 505                 510         


Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu Met Glu Asp Ala Tyr His 
        515                 520                 525             


Glu His Gln Ala Asn Leu Leu Arg Gln Asp Leu Met Arg Arg Gln Glu 
    530                 535                 540                 


Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Met Gln Lys Arg 
545                 550                 555                 560 


Lys Glu Met Gln Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu Glu 
                565                 570                 575     


Glu Met Met Ile Arg Gln Arg Glu Met Glu Glu Gln Met Arg Arg Gln 
            580                 585                 590         


Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr Met Asp Pro Arg Glu Arg 
        595                 600                 605             


Asp Met Arg Met Gly Gly Gly Gly Ala Met Asn Met Gly Asp Pro Tyr 
    610                 615                 620                 


Gly Ser Gly Gly Gln Lys Phe Pro Pro Leu Gly Gly Gly Gly Gly Ile 
625                 630                 635                 640 


Gly Tyr Glu Ala Asn Pro Gly Val Pro Pro Ala Thr Met Ser Gly Ser 
                645                 650                 655     


Met Met Gly Ser Asp Met Arg Thr Glu Arg Phe Gly Gln Gly Gly Ala 
            660                 665                 670         


Gly Pro Val Gly Gly Gln Gly Pro Arg Gly Met Gly Pro Gly Thr Pro 
        675                 680                 685             


Ala Gly Tyr Gly Arg Gly Arg Glu Glu Tyr Glu Gly Pro Asn Lys Lys 
    690                 695                 700                 


Pro Arg Phe 
705         


<210>  119
<211>  7011
<212>  DNA
<213>  Homosapiens

<400>  119
agtgtgggcg ggggccgggg ggccgagagg taccgccgcc accgcgcggg gagccgcagc     60

ggttccgagc ggggcccaac atggcggaga gagaggtgga gtccggcccc cgaaagaggt    120

ttgaacaaaa aagtggtgca gtttttgatg aaattgtaga gaactgtggt ggtatcatgg    180

atacagaaat gtctgaagat atagaccaca acttaactcc tacccttgac agcatgtctt    240

atggaatgcc gaatcaaaca ggatctgaaa attcattgct ggatgaagat gattattttt    300

tgaactctgg ggatcttgca ggaattccag tcgttggtag tgacaatgag gatgaacagg    360

attttagttc aaaggacaat cttgtttctt caattcatac tgatgatagc ttggaagtag    420

agagaagagt cacacagcat gaatcagaca atgaaaatga aatacaaatt caaaataagt    480

taaaaaaaga ctttcctaaa caatttgatc aggtttctgt ctttaaatca atacggaaag    540

attttagtct agtaagagaa aacagcaaag agacattttc tggaaaggag aaaaatagag    600

acctaactta tgaacgtgaa aaacggttgg ataaacccca taaagatttg gattcaaggt    660

tgaaaagcag tttttttgat aaagcagcta atcaagttga agaaacatta catacccatt    720

taccacaaac cccagaaaca aactttaggg attccagcta cccatttgcc aataaagaat    780

ccattggttc ggaactgggg aattcctttg catcaaatat tagaattaaa gaagaacctt    840

tggatgatga gtatgacaaa gcaatggcac cacagcaggg actactagac aaaataaaag    900

atgaacctga caatgctcaa gagtatagtc atggccaaca gcaaaaaact caagaggggg    960

aactgaaaat tagtgctgtg ttttcagtca gtggcagccc tcttgctcca cagttgacta   1020

ctggctttca gccctcactg gcgtcatctg gcatgaataa aatgcttcct tcagttccag   1080

ccacagctgt tcgagtttcc tgttctggtt gtaaaaaaat cctccagaag gggcaaactg   1140

cttatcagag gaaagggtct actcagctat tctgctccac actgtgcctc actggatata   1200

cagttccacc tgcccgccca ccgcctcctc tcaccaagaa aacttgttca agttgctcaa   1260

aagacatttt aaatccaaag gatgtgatca gtgcccagtt tgaaaacacc accactagta   1320

aagatttttg cagtcagtca tgtttgtcaa catatgaact gaaaaaaaaa cctattgtta   1380

ccataaatac aaatagtatt tcaaccaaat gcagcatgtg tcagaagaat gctgttattc   1440

gacatgaagt taattaccag aatgtggtcc ataaactttg cagtgatgcc tgcttctcta   1500

agtttcgttc tgctaacaac ctcaccatga actgttgtga gaactgtggg ggttactgtt   1560

acagtgggtc gggacaatgc cacatgcttc agatagaggg acagtctaag aagttttgta   1620

gttcatcgtg tatcacggca tacaagcaga aatcagccaa aattacaccg tgtgcgcttt   1680

gcaaatcatt gagatcctca gcagaaatga ttgaaaatac caatagcttg gggaagacag   1740

agcttttctg ttctgttaat tgcttatctg cttacagagt taaaatggtt acttctgcag   1800

gtgtacaagt tcagtgtaac agttgtaaaa cctcagcaat tcctcagtat cacctagcca   1860

tgtcagatgg aagtatacgc aacttctgca gctacagctg tgtggtagct ttccagaatt   1920

tattcaacaa accaactgga atgaattctt cagtagtgcc cttgtctcag ggccaagtaa   1980

ttgtaagcat ccccacaggt tccacagtgt cagccggagg aggtagcaca tctgctgttt   2040

ctcccacctc catcagtagc tctgctgcag ctggtctcca gcgtctcgct gcccagtccc   2100

agcatgttgg gtttgcacga agtgttgtga aactcaaatg tcaacactgt aaccgtcttt   2160

ttgccacaaa accagaactt cttgactata agggcaaaat gtttcagttc tgtggcaaga   2220

attgttctga tgaatataag aaaataaata atgtaatggc aatgtgtgaa tattgtaaaa   2280

ttgagaaaat tgtaaaggag actgttcggt tctcaggtgc tgacaagtca ttctgtagtg   2340

aaggttgcaa attgctttat aaacatgact tggcaaaacg ctggggaaat cactgtaaaa   2400

tgtgcagtta ttgtttacag acatctccca aattggtaca gaataattta ggagggaaag   2460

tggaagagtt ctgttgtgaa gaatgcatgt ccaaatatac agttttgttc tatcagatgg   2520

ccaaatgtga tgcttgtaag cgacagggta aactcagtga gtccttgaaa tggcgagggg   2580

aaatgaaaca tttctgtaac ctgctttgta tcttgatgtt ctgtaatcag caaagtgtat   2640

gtgacccgcc ttcacaaaat aatgcagcaa atatttccat ggttcaagct gcttcagcag   2700

gacccccatc tctgagaaaa gattcgactc cagttatagc caatgtagta tcattggcaa   2760

gtgcccctgc tgctcagcct acagtgaatt ctaacagtgt cttacaaggt gcagttccaa   2820

cagtaacagc gaaaatcatc ggtgatgcaa gtactcaaac agatgccctg aaactgccac   2880

cttcccaacc tccaaggctt ttgaagaaca aagctttatt atgcaaaccc atcacacaga   2940

ctaaagccac ctcttgcaaa ccacataccc aaaacaaaga atgccagaca gaagacactc   3000

caagtcagcc ccagattatt gtggtgccag ttcccgtacc agtgtttgtt cccatacctc   3060

ttcaccttta tactcaatat gctccagtcc catttggaat tccagttcca atgcctgtcc   3120

ctatgcttat tccatcttca atggatagtg aagataaagt cacagagagt attgaagaca   3180

ttaaagaaaa gcttcccaca catccatttg aagctgatct ccttgagatg gcagaaatga   3240

ttgcagaaga tgaagagaag aagactctat ctcagggaga gtcccaaact tctgaacacg   3300

aactctttct agacaccaag atatttgaaa aagaccaagg aagtacatac agtggtgatc   3360

ttgaatcaga ggcagtatct actccacata gctgggagga agagctgaat cactatgcct   3420

taaagtcaaa tgctgtgcaa gaggctgatt cagaattgaa gcagttctca aaaggggaaa   3480

ctgaacagga cctggaagca gattttccat cagactcctt tgacccactt aataaaggac   3540

agggaatcca ggcacgttcc cgaacaagac gacgacacag agatggcttc ccccaaccca   3600

gacgaagagg acggaagaag tctatagtgg ctgtggagcc caggagtctt attcaaggag   3660

cctttcaagg ctgctcagtg tccgggatga cactgaaata catgtatggg gtaaatgctt   3720

ggaagaactg ggttcagtgg aaaaatgcca aggaagagca gggggatcta aaatgtggag   3780

gggttgaaca ggcctcatct agcccacgtt ctgacccctt aggaagtact caagaccatg   3840

cactctctca agaatcctca gagccaggct gtagagtccg ctctatcaag ctgaaggaag   3900

acattctgtc ctgcactttt gctgagttga gtttgggctt atgccagttt atccaagagg   3960

tgcggagacc aaatggtgaa aaatatgatc cagacagtat cttatacttg tgccttggaa   4020

ttcaacagta cctgtttgaa aatggtagaa tagataacat ttttactgag ccctattcca   4080

gatttatgat tgaacttacc aaactcttga aaatatggga acctacaata cttcctaatg   4140

gttacatgtt ctctcgcatt gaggaagagc atttgtggga gtgcaaacag ctgggcgctt   4200

actcaccaat cgtcctttta aacaccctcc ttttcttcaa taccaaatac ttccaactaa   4260

agaatgttac tgagcacttg aagctttcct ttgcccatgt gatgagacgg accaggactc   4320

tgaagtacag taccaagatg acatatctga ggttcttccc acctttacag aagcaggagt   4380

cagaaccaga taaactgact gttggcaaga ggaaacgaaa tgaagatgat gaggttccag   4440

tgggggtgga gatggcagag aatactgaca atccactaag atgcccagtc cgactttatg   4500

agttttacct gtcaaaatgt tctgaaagtg tgaagcaaag gaatgatgtg ttttaccttc   4560

aacctgagcg ctcctgtgtc ccgaatagcc ccatgtggta ctccacattc ccgatagacc   4620

ctggaaccct ggacaccatg ttaacacgta ttctcatggt gagggaggta catgaagaac   4680

ttgccaaagc caaatctgaa gactctgatg ttgaattatc agattaaaac ggaagtgagg   4740

ttcttatttt catacatatt ggtatgcacc aaactgtgaa tgcatccagc tgttggaaaa   4800

tgatgtataa gtctaagtcc tcttgacttg accataagat catggaaaac agatgacttg   4860

tgaaccccac agtgtggatg tgcaaatgaa aattgaagga aagaatatga actgagaaat   4920

gttctttggc agtgatatag ttcttagaca tcttcagaat gactaatttc tccgagtggt   4980

gcataatctt attttgtttg ggagtaacaa atcgtggaat atttttaagg aaaactgttg   5040

tataaaactt taccatagta accttagacc ttagagaggt agctttggag tgaaactttg   5100

gctgcaatag gctactttgg caagccctcc gtaaaagtca gaggagagat cagtacagag   5160

ctaagagtga catcaaatga ggactgtggg acccagattt gaagacccaa taaaaatact   5220

caacttttta aaaaagatag tgaagtggtc ttgattgatt ttgattttca ctgccaagcc   5280

aatcatgtga aggacagaag cttttgccat gggcccctca catcagggaa aatgaccttc   5340

actgctgtta acagtaatgt gtccctttca ttttctggat caagccttct cagcggtggg   5400

tctggatgtg ggtaaactaa ggtaaagggg atgatattcc acaaactaat tatgcacaca   5460

gaaaatctgt ggagcctatc agaccccaag tgtcttgaaa tgtttgtaga aacccactaa   5520

aatgcccctt ctctgggtgt gggcccttat tgcagctgtc tcacagcctg agctgtggta   5580

cagagaaatg ggggttctcc ttttattttc attttttttc cccaatggca gcttttctcc   5640

cgttgtttta ccttcctatt tcccaaacag ttcctcttat tttgtctttt gcaccagttt   5700

ctggaggccc ttgtcatttc aaaaaggata gtctcttttc ttactctggc aaacctgtga   5760

gtgattccac aaagatacag tattacttag ctatctgaat tatgatagaa aaggtcctag   5820

ttaggttcct atataaagca tttggaagat gaccttgttg cccttgaaac ttgaaaatag   5880

ggattctggg gtgaggatac aaagacattg tcttgcatat ccataagcag gtcttagagc   5940

attattccaa actctagctg tttcagtagt tctatgagga ttgcaagtca taggtgtgtg   6000

tggcatatca gtccatctcc ctcatctcca ttctcagttt cttccccaca aaatttggaa   6060

tcaaagcttt tatgacgttt gccaattgca gaacttcttc agctaaggtt aatttgacgc   6120

tatgataaaa ctgagagatg tcaaaaagcc tcttagaaat tttaatcttg aaagactttt   6180

cagggtatct cattttttag gtgggggtgg caggtgtatt tcttttttaa caaataaaag   6240

gcatttaagt aaaactaaaa tgaaaaaagt aggccttctg acattgtgta cttggtggtt   6300

ctgtccctct gcctgtaaca aatctcattt ttgttaccaa gaactgtatg aaagaagtaa   6360

atccaccccg attctgtatg attaattcca tctgtgtttg tcatttctga ctggaaaact   6420

tcttactcca taccttgttc gatatggagg acaaataatt ggattgtctg ataagtctgc   6480

caataaacta tccagaaata gcaagtgtaa tagtccccac tatacgaatt ttatggtttg   6540

tataaacact aacattttcc ccttctgtag ttgtatgaaa aaacaaatat tgttagcata   6600

gtagataaat tgttatgaaa taccagaaaa aaaaatctgt atcttttact gagaacaccc   6660

aatacccaga taaatgactg tatcaggatt tcatttgcat gttagtccac agagttgccc   6720

agaaccctaa atttattcat aagagaaaat attgattaat tattggtcat tcctcataag   6780

tgtagctgtt gatgtgtgcg tctgattatt gcttttttaa ttttatgaaa attgtgtaaa   6840

attacatttt ttttccaggg gagaaaaaaa catcaaacaa aaacatctaa atcatccttt   6900

ttgttctttt tcagttttta accactttta ggttttcccc ttacagaaac cacagaaata   6960

ttcccttaga ataaaatagt atatttgtat ttgaaaaaaa aaaaaaaaaa a            7011


<210>  120
<211>  1548
<212>  PRT
<213>  Homosapiens

<400>  120

Met Ala Glu Arg Glu Val Glu Ser Gly Pro Arg Lys Arg Phe Glu Gln 
1               5                   10                  15      


Lys Ser Gly Ala Val Phe Asp Glu Ile Val Glu Asn Cys Gly Gly Ile 
            20                  25                  30          


Met Asp Thr Glu Met Ser Glu Asp Ile Asp His Asn Leu Thr Pro Thr 
        35                  40                  45              


Leu Asp Ser Met Ser Tyr Gly Met Pro Asn Gln Thr Gly Ser Glu Asn 
    50                  55                  60                  


Ser Leu Leu Asp Glu Asp Asp Tyr Phe Leu Asn Ser Gly Asp Leu Ala 
65                  70                  75                  80  


Gly Ile Pro Val Val Gly Ser Asp Asn Glu Asp Glu Gln Asp Phe Ser 
                85                  90                  95      


Ser Lys Asp Asn Leu Val Ser Ser Ile His Thr Asp Asp Ser Leu Glu 
            100                 105                 110         


Val Glu Arg Arg Val Thr Gln His Glu Ser Asp Asn Glu Asn Glu Ile 
        115                 120                 125             


Gln Ile Gln Asn Lys Leu Lys Lys Asp Phe Pro Lys Gln Phe Asp Gln 
    130                 135                 140                 


Val Ser Val Phe Lys Ser Ile Arg Lys Asp Phe Ser Leu Val Arg Glu 
145                 150                 155                 160 


Asn Ser Lys Glu Thr Phe Ser Gly Lys Glu Lys Asn Arg Asp Leu Thr 
                165                 170                 175     


Tyr Glu Arg Glu Lys Arg Leu Asp Lys Pro His Lys Asp Leu Asp Ser 
            180                 185                 190         


Arg Leu Lys Ser Ser Phe Phe Asp Lys Ala Ala Asn Gln Val Glu Glu 
        195                 200                 205             


Thr Leu His Thr His Leu Pro Gln Thr Pro Glu Thr Asn Phe Arg Asp 
    210                 215                 220                 


Ser Ser Tyr Pro Phe Ala Asn Lys Glu Ser Ile Gly Ser Glu Leu Gly 
225                 230                 235                 240 


Asn Ser Phe Ala Ser Asn Ile Arg Ile Lys Glu Glu Pro Leu Asp Asp 
                245                 250                 255     


Glu Tyr Asp Lys Ala Met Ala Pro Gln Gln Gly Leu Leu Asp Lys Ile 
            260                 265                 270         


Lys Asp Glu Pro Asp Asn Ala Gln Glu Tyr Ser His Gly Gln Gln Gln 
        275                 280                 285             


Lys Thr Gln Glu Gly Glu Leu Lys Ile Ser Ala Val Phe Ser Val Ser 
    290                 295                 300                 


Gly Ser Pro Leu Ala Pro Gln Leu Thr Thr Gly Phe Gln Pro Ser Leu 
305                 310                 315                 320 


Ala Ser Ser Gly Met Asn Lys Met Leu Pro Ser Val Pro Ala Thr Ala 
                325                 330                 335     


Val Arg Val Ser Cys Ser Gly Cys Lys Lys Ile Leu Gln Lys Gly Gln 
            340                 345                 350         


Thr Ala Tyr Gln Arg Lys Gly Ser Thr Gln Leu Phe Cys Ser Thr Leu 
        355                 360                 365             


Cys Leu Thr Gly Tyr Thr Val Pro Pro Ala Arg Pro Pro Pro Pro Leu 
    370                 375                 380                 


Thr Lys Lys Thr Cys Ser Ser Cys Ser Lys Asp Ile Leu Asn Pro Lys 
385                 390                 395                 400 


Asp Val Ile Ser Ala Gln Phe Glu Asn Thr Thr Thr Ser Lys Asp Phe 
                405                 410                 415     


Cys Ser Gln Ser Cys Leu Ser Thr Tyr Glu Leu Lys Lys Lys Pro Ile 
            420                 425                 430         


Val Thr Ile Asn Thr Asn Ser Ile Ser Thr Lys Cys Ser Met Cys Gln 
        435                 440                 445             


Lys Asn Ala Val Ile Arg His Glu Val Asn Tyr Gln Asn Val Val His 
    450                 455                 460                 


Lys Leu Cys Ser Asp Ala Cys Phe Ser Lys Phe Arg Ser Ala Asn Asn 
465                 470                 475                 480 


Leu Thr Met Asn Cys Cys Glu Asn Cys Gly Gly Tyr Cys Tyr Ser Gly 
                485                 490                 495     


Ser Gly Gln Cys His Met Leu Gln Ile Glu Gly Gln Ser Lys Lys Phe 
            500                 505                 510         


Cys Ser Ser Ser Cys Ile Thr Ala Tyr Lys Gln Lys Ser Ala Lys Ile 
        515                 520                 525             


Thr Pro Cys Ala Leu Cys Lys Ser Leu Arg Ser Ser Ala Glu Met Ile 
    530                 535                 540                 


Glu Asn Thr Asn Ser Leu Gly Lys Thr Glu Leu Phe Cys Ser Val Asn 
545                 550                 555                 560 


Cys Leu Ser Ala Tyr Arg Val Lys Met Val Thr Ser Ala Gly Val Gln 
                565                 570                 575     


Val Gln Cys Asn Ser Cys Lys Thr Ser Ala Ile Pro Gln Tyr His Leu 
            580                 585                 590         


Ala Met Ser Asp Gly Ser Ile Arg Asn Phe Cys Ser Tyr Ser Cys Val 
        595                 600                 605             


Val Ala Phe Gln Asn Leu Phe Asn Lys Pro Thr Gly Met Asn Ser Ser 
    610                 615                 620                 


Val Val Pro Leu Ser Gln Gly Gln Val Ile Val Ser Ile Pro Thr Gly 
625                 630                 635                 640 


Ser Thr Val Ser Ala Gly Gly Gly Ser Thr Ser Ala Val Ser Pro Thr 
                645                 650                 655     


Ser Ile Ser Ser Ser Ala Ala Ala Gly Leu Gln Arg Leu Ala Ala Gln 
            660                 665                 670         


Ser Gln His Val Gly Phe Ala Arg Ser Val Val Lys Leu Lys Cys Gln 
        675                 680                 685             


His Cys Asn Arg Leu Phe Ala Thr Lys Pro Glu Leu Leu Asp Tyr Lys 
    690                 695                 700                 


Gly Lys Met Phe Gln Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys 
705                 710                 715                 720 


Lys Ile Asn Asn Val Met Ala Met Cys Glu Tyr Cys Lys Ile Glu Lys 
                725                 730                 735     


Ile Val Lys Glu Thr Val Arg Phe Ser Gly Ala Asp Lys Ser Phe Cys 
            740                 745                 750         


Ser Glu Gly Cys Lys Leu Leu Tyr Lys His Asp Leu Ala Lys Arg Trp 
        755                 760                 765             


Gly Asn His Cys Lys Met Cys Ser Tyr Cys Leu Gln Thr Ser Pro Lys 
    770                 775                 780                 


Leu Val Gln Asn Asn Leu Gly Gly Lys Val Glu Glu Phe Cys Cys Glu 
785                 790                 795                 800 


Glu Cys Met Ser Lys Tyr Thr Val Leu Phe Tyr Gln Met Ala Lys Cys 
                805                 810                 815     


Asp Ala Cys Lys Arg Gln Gly Lys Leu Ser Glu Ser Leu Lys Trp Arg 
            820                 825                 830         


Gly Glu Met Lys His Phe Cys Asn Leu Leu Cys Ile Leu Met Phe Cys 
        835                 840                 845             


Asn Gln Gln Ser Val Cys Asp Pro Pro Ser Gln Asn Asn Ala Ala Asn 
    850                 855                 860                 


Ile Ser Met Val Gln Ala Ala Ser Ala Gly Pro Pro Ser Leu Arg Lys 
865                 870                 875                 880 


Asp Ser Thr Pro Val Ile Ala Asn Val Val Ser Leu Ala Ser Ala Pro 
                885                 890                 895     


Ala Ala Gln Pro Thr Val Asn Ser Asn Ser Val Leu Gln Gly Ala Val 
            900                 905                 910         


Pro Thr Val Thr Ala Lys Ile Ile Gly Asp Ala Ser Thr Gln Thr Asp 
        915                 920                 925             


Ala Leu Lys Leu Pro Pro Ser Gln Pro Pro Arg Leu Leu Lys Asn Lys 
    930                 935                 940                 


Ala Leu Leu Cys Lys Pro Ile Thr Gln Thr Lys Ala Thr Ser Cys Lys 
945                 950                 955                 960 


Pro His Thr Gln Asn Lys Glu Cys Gln Thr Glu Asp Thr Pro Ser Gln 
                965                 970                 975     


Pro Gln Ile Ile Val Val Pro Val Pro Val Pro Val Phe Val Pro Ile 
            980                 985                 990         


Pro Leu His Leu Tyr Thr Gln Tyr  Ala Pro Val Pro Phe  Gly Ile Pro 
        995                 1000                 1005             


Val Pro  Met Pro Val Pro Met  Leu Ile Pro Ser Ser  Met Asp Ser 
    1010                 1015                 1020             


Glu Asp  Lys Val Thr Glu Ser  Ile Glu Asp Ile Lys  Glu Lys Leu 
    1025                 1030                 1035             


Pro Thr  His Pro Phe Glu Ala  Asp Leu Leu Glu Met  Ala Glu Met 
    1040                 1045                 1050             


Ile Ala  Glu Asp Glu Glu Lys  Lys Thr Leu Ser Gln  Gly Glu Ser 
    1055                 1060                 1065             


Gln Thr  Ser Glu His Glu Leu  Phe Leu Asp Thr Lys  Ile Phe Glu 
    1070                 1075                 1080             


Lys Asp  Gln Gly Ser Thr Tyr  Ser Gly Asp Leu Glu  Ser Glu Ala 
    1085                 1090                 1095             


Val Ser  Thr Pro His Ser Trp  Glu Glu Glu Leu Asn  His Tyr Ala 
    1100                 1105                 1110             


Leu Lys  Ser Asn Ala Val Gln  Glu Ala Asp Ser Glu  Leu Lys Gln 
    1115                 1120                 1125             


Phe Ser  Lys Gly Glu Thr Glu  Gln Asp Leu Glu Ala  Asp Phe Pro 
    1130                 1135                 1140             


Ser Asp  Ser Phe Asp Pro Leu  Asn Lys Gly Gln Gly  Ile Gln Ala 
    1145                 1150                 1155             


Arg Ser  Arg Thr Arg Arg Arg  His Arg Asp Gly Phe  Pro Gln Pro 
    1160                 1165                 1170             


Arg Arg  Arg Gly Arg Lys Lys  Ser Ile Val Ala Val  Glu Pro Arg 
    1175                 1180                 1185             


Ser Leu  Ile Gln Gly Ala Phe  Gln Gly Cys Ser Val  Ser Gly Met 
    1190                 1195                 1200             


Thr Leu  Lys Tyr Met Tyr Gly  Val Asn Ala Trp Lys  Asn Trp Val 
    1205                 1210                 1215             


Gln Trp  Lys Asn Ala Lys Glu  Glu Gln Gly Asp Leu  Lys Cys Gly 
    1220                 1225                 1230             


Gly Val  Glu Gln Ala Ser Ser  Ser Pro Arg Ser Asp  Pro Leu Gly 
    1235                 1240                 1245             


Ser Thr  Gln Asp His Ala Leu  Ser Gln Glu Ser Ser  Glu Pro Gly 
    1250                 1255                 1260             


Cys Arg  Val Arg Ser Ile Lys  Leu Lys Glu Asp Ile  Leu Ser Cys 
    1265                 1270                 1275             


Thr Phe  Ala Glu Leu Ser Leu  Gly Leu Cys Gln Phe  Ile Gln Glu 
    1280                 1285                 1290             


Val Arg  Arg Pro Asn Gly Glu  Lys Tyr Asp Pro Asp  Ser Ile Leu 
    1295                 1300                 1305             


Tyr Leu  Cys Leu Gly Ile Gln  Gln Tyr Leu Phe Glu  Asn Gly Arg 
    1310                 1315                 1320             


Ile Asp  Asn Ile Phe Thr Glu  Pro Tyr Ser Arg Phe  Met Ile Glu 
    1325                 1330                 1335             


Leu Thr  Lys Leu Leu Lys Ile  Trp Glu Pro Thr Ile  Leu Pro Asn 
    1340                 1345                 1350             


Gly Tyr  Met Phe Ser Arg Ile  Glu Glu Glu His Leu  Trp Glu Cys 
    1355                 1360                 1365             


Lys Gln  Leu Gly Ala Tyr Ser  Pro Ile Val Leu Leu  Asn Thr Leu 
    1370                 1375                 1380             


Leu Phe  Phe Asn Thr Lys Tyr  Phe Gln Leu Lys Asn  Val Thr Glu 
    1385                 1390                 1395             


His Leu  Lys Leu Ser Phe Ala  His Val Met Arg Arg  Thr Arg Thr 
    1400                 1405                 1410             


Leu Lys  Tyr Ser Thr Lys Met  Thr Tyr Leu Arg Phe  Phe Pro Pro 
    1415                 1420                 1425             


Leu Gln  Lys Gln Glu Ser Glu  Pro Asp Lys Leu Thr  Val Gly Lys 
    1430                 1435                 1440             


Arg Lys  Arg Asn Glu Asp Asp  Glu Val Pro Val Gly  Val Glu Met 
    1445                 1450                 1455             


Ala Glu  Asn Thr Asp Asn Pro  Leu Arg Cys Pro Val  Arg Leu Tyr 
    1460                 1465                 1470             


Glu Phe  Tyr Leu Ser Lys Cys  Ser Glu Ser Val Lys  Gln Arg Asn 
    1475                 1480                 1485             


Asp Val  Phe Tyr Leu Gln Pro  Glu Arg Ser Cys Val  Pro Asn Ser 
    1490                 1495                 1500             


Pro Met  Trp Tyr Ser Thr Phe  Pro Ile Asp Pro Gly  Thr Leu Asp 
    1505                 1510                 1515             


Thr Met  Leu Thr Arg Ile Leu  Met Val Arg Glu Val  His Glu Glu 
    1520                 1525                 1530             


Leu Ala  Lys Ala Lys Ser Glu  Asp Ser Asp Val Glu  Leu Ser Asp 
    1535                 1540                 1545             


<210>  121
<211>  4804
<212>  DNA
<213>  Homosapiens

<400>  121
gtttccggcc gccgtcgctg tccagggagg ctgaggcgag aggtagctgt ccgggtgggg     60

agcccgcact accttcttcc tcttcctcct cctcctccgg gtgaggggag cgaaggttgg    120

gggtccccga gcccatggac caggaggagg cggaggccgc cgagagccgg ggccccgcta    180

tgtggccctg agccccgtgt actggttctg cctgtctgga gggccatgga gaagaggctg    240

ggagtcaagc caaatcctgc ttcctggatt ttatcaggat attattggca gacatctgcg    300

aagtggttga gaagcctgta cctgttttat acttgctttt gcttcagcgt tctgtggttg    360

tcaacagatg ccagtgagag caggtgccag caggggaaga cacaatttgg agttggcctg    420

agatctgggg gagaaaatca cctctggctt cttgaaggaa ccccctctct ccagtcatgt    480

tgggctgcct gctgccagga ctctgcctgc catgtctttt ggtggctaga agggatgtgc    540

attcaggcag actgcagcag gccccagagc tgccgggctt ttaggacaca ctcctccaat    600

tccatgctgg tgtttttaaa aaaattccaa actgcagatg atttgggctt tctacctgaa    660

gatgatgtac cacatcttct ggggctaggt tggaactggg catcttggag gcagagccca    720

cccagagctg cactcagacc tgctgtatct tccagtgacc agcagagctt aatcaggaag    780

cttcagaaga gaggtagtcc cagtgacgta gttacaccta tagtgacaca gcattctaaa    840

gtgaatgact ccaacgaatt aggtggtctg actaccagtg gctctgcaga ggtccacaag    900

gcgattacaa tttccagtcc cctaaccaca gacctgactg cagagctgtc tggtgggcca    960

aagaatgtat cagtgcaacc tgaaatatca gagggtcttg ctactacgcc cagcactcaa   1020

caagtaaaaa gttctgagaa aacccagatt gctgtccccc agccagtggc tccctcctac   1080

agttatgcta cccctacccc ccaggcctct ttccagagca cctcagcacc atacccagtt   1140

ataaaggaac tggtggtatc tgctggagag agtgtccaga taaccctgcc taagaatgaa   1200

gttcaattaa atgcatatgt tctccaagaa ccacctaaag gagaaaccta cacctacgac   1260

tggcagctga ttactcatcc tagagactac agtggagaaa tggaagggaa acattcccag   1320

atcctcaaac tatcgaagct cactccaggc ctgtatgaat tcaaagtgat tgtagagggt   1380

caaaatgccc atggggaagg ctatgtgaac gtgacagtca agccagagcc ccgtaagaat   1440

cggcccccca ttgctattgt gtcacctcag ttccaggaga tctctttgcc aaccacttct   1500

acagtcattg atggcagtca aagcactgat gatgataaaa tcgttcagta ccattgggaa   1560

gaacttaagg ggcctctaag agaagagaag atttctgaag atacagccat attaaaacta   1620

agtaaactcg tccctgggaa ctacactttc agcttgactg tagtagactc tgatggagct   1680

accaactcta ctactgcaaa cctgacagtg aacaaagctg tggattaccc ccctgtggcc   1740

aacgcaggcc ccaaccaagt gatcaccctg ccccaaaact ccatcaccct ctttgggaac   1800

cagagcactg atgatcatgg catcaccagc tatgagtggt cactcagccc aagcagcaaa   1860

gggaaagtgg tggagatgca gggtgttaga acaccaacct tacagctctc tgcgatgcaa   1920

gaaggagact acacttacca gctcacagtg actgacacaa taggacagca ggccactgct   1980

caagtgactg ttattgtgca acctgaaaac aataagcctc ctcaggcaga tgcaggccca   2040

gataaagagc tgacccttcc tgtggatagc acaaccctgg atggcagcaa gagctcagat   2100

gatcagaaaa ttatctcata tctctgggaa aaaacacagg gacctgatgg ggtgcagctc   2160

gagaatgcta acagcagtgt tgctactgtg actgggctgc aagtggggac ctatgtgttc   2220

accttgactg tcaaagatga gaggaacctg caaagccaga gctctgtgaa tgtcattgtc   2280

aaagaagaaa taaacaaacc acctatagcc aagataactg ggaatgtggt gattacccta   2340

cccacgagca cagcagagct ggatggctct aagtcctcag atgacaaggg aatagtcagc   2400

tacctctgga ctcgagatga ggggagccca gcagcagggg aggtgttaaa tcactctgac   2460

catcacccta tcctttttct ttcaaacctg gttgagggaa cctacacttt tcacctgaaa   2520

gtgaccgatg caaagggtga gagtgacaca gaccggacca ctgtggaggt gaaacctgat   2580

cccaggaaaa acaacctggt ggagatcatc ttggatatca acgtcagtca gctaactgag   2640

aggctgaagg ggatgttcat ccgccagatt ggggtcctcc tgggggtgct ggattccgac   2700

atcattgtgc aaaagattca gccgtacacg gagcagagca ccaaaatggt attttttgtt   2760

caaaacgagc ctccccacca gatcttcaaa ggccatgagg tggcagcgat gctcaagagt   2820

gagctgcgga agcaaaaggc agactttttg atattcagag ccttggaagt caacactgtc   2880

acatgtcagc tgaactgttc cgaccatggc cactgtgact cgttcaccaa acgctgtatc   2940

tgtgaccctt tttggatgga gaatttcatc aaggtgcagc tgagggatgg agacagcaac   3000

tgtgagtgga gcgtgttata tgttatcatt gctacctttg tcattgttgt tgccttggga   3060

atcctgtctt ggactgtgat ctgttgttgt aagaggcaaa aaggaaaacc caagaggaaa   3120

agcaagtaca agatcctgga tgccacggat caggaaagcc tggagctgaa gccaacctcc   3180

cgagcaggca tcaaacagaa aggccttttg ctaagtagca gcctgatgca ctccgagtca   3240

gagctggaca gcgatgatgc catctttaca tggccagacc gagagaaggg caaactcctg   3300

catggtcaga atggctctgt acccaacggg cagacccctc tgaaggccag gagcccgcgg   3360

gaggagatcc tgtagccacc tggtctgtct cctcagggca gggcccagca cactgcccgg   3420

ccagtcctcc tacctcccga gtctgcgggc agctgctgtc ccagcatctg ctggtcattt   3480

cgccctgaca gtcccaacca gaacccctgg gacttgaatc cagagacgtc ctccaggaac   3540

ccctcaacga agctgtgaat gaagaggttt cctctttaaa cctgtctggt gggcccccag   3600

atatcctcac ctcagggcct cctttttttg caaactcctc ccctcccccg agggcagacc   3660

cagccagctg ctaagctctg cagctcccca gtggacagtg tcattgtgcc cagagtgctg   3720

caaggtgagg cctgctgtgc tgcccgcaca cctgagtgca aaaccaagca ctgtgggcat   3780

ggtgtttccc tctctggggt agagtacgcc ctctcgctgg gcaaagagga agtggcaccc   3840

ctcccctcac cacagatgct gagatggtag catagaaatg atggccgggc gcggtggctc   3900

acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg gatcatgagg tcaggagatc   3960

aagaccaccc tggctaacac ggtgaaaccc catctctact aaaaataaaa aaaaaaatta   4020

gccgggtttg gtggcgtatg cctgtaatcc cagctactcg ggaggctgag gcaggagaat   4080

tgcttaaacc tgggaggtgg aggctgcagt gagccaagat cgtgccactg cactccagcc   4140

tgagtgacag agcaagactc cgtcaaaaaa aaaaaaaaaa aaaaagaaat gatatctggc   4200

ccccccttaa cactggagcc ccactccctt ctcccatccg gcccgagatt agggaggatt   4260

gactgtgtca gggatggcgg gtggcctctc tcgctgccag ggcccttgtc agagcagcca   4320

ggctggacag acggcctccc tcctctccat ctgaccggca cctgctgctt cggggcttag   4380

gccaccgctc cctgtcccca gaggagatag ccccagatgg actggaatgt tgtggcatga   4440

gagcgcatgt gtgcgatggc cccgctgtgg tcccctctct gtccctccat ctgtatgtgt   4500

tctgtgtccc ttgcatgtgt gcgtgttaga gtgagcgcgt atgcatcaac tcattgggct   4560

cttggctgct cacaaggcaa atttgacttg gaaagacttt catctccttg gaaccaagac   4620

ttcctgagtc cccctcaccc tggccctgtt ccaccatggt tatctgggta ttggggaatg   4680

gaaactttgg gggagtgact ttttaaagag acacttataa tttctactac tgcactactg   4740

tccattgtgg gatgattaaa catggtattt aactgtgcaa aaaaaaaaaa aaaaaaaaaa   4800

aaaa                                                                4804


<210>  122
<211>  1049
<212>  PRT
<213>  Homosapiens

<400>  122

Met Glu Lys Arg Leu Gly Val Lys Pro Asn Pro Ala Ser Trp Ile Leu 
1               5                   10                  15      


Ser Gly Tyr Tyr Trp Gln Thr Ser Ala Lys Trp Leu Arg Ser Leu Tyr 
            20                  25                  30          


Leu Phe Tyr Thr Cys Phe Cys Phe Ser Val Leu Trp Leu Ser Thr Asp 
        35                  40                  45              


Ala Ser Glu Ser Arg Cys Gln Gln Gly Lys Thr Gln Phe Gly Val Gly 
    50                  55                  60                  


Leu Arg Ser Gly Gly Glu Asn His Leu Trp Leu Leu Glu Gly Thr Pro 
65                  70                  75                  80  


Ser Leu Gln Ser Cys Trp Ala Ala Cys Cys Gln Asp Ser Ala Cys His 
                85                  90                  95      


Val Phe Trp Trp Leu Glu Gly Met Cys Ile Gln Ala Asp Cys Ser Arg 
            100                 105                 110         


Pro Gln Ser Cys Arg Ala Phe Arg Thr His Ser Ser Asn Ser Met Leu 
        115                 120                 125             


Val Phe Leu Lys Lys Phe Gln Thr Ala Asp Asp Leu Gly Phe Leu Pro 
    130                 135                 140                 


Glu Asp Asp Val Pro His Leu Leu Gly Leu Gly Trp Asn Trp Ala Ser 
145                 150                 155                 160 


Trp Arg Gln Ser Pro Pro Arg Ala Ala Leu Arg Pro Ala Val Ser Ser 
                165                 170                 175     


Ser Asp Gln Gln Ser Leu Ile Arg Lys Leu Gln Lys Arg Gly Ser Pro 
            180                 185                 190         


Ser Asp Val Val Thr Pro Ile Val Thr Gln His Ser Lys Val Asn Asp 
        195                 200                 205             


Ser Asn Glu Leu Gly Gly Leu Thr Thr Ser Gly Ser Ala Glu Val His 
    210                 215                 220                 


Lys Ala Ile Thr Ile Ser Ser Pro Leu Thr Thr Asp Leu Thr Ala Glu 
225                 230                 235                 240 


Leu Ser Gly Gly Pro Lys Asn Val Ser Val Gln Pro Glu Ile Ser Glu 
                245                 250                 255     


Gly Leu Ala Thr Thr Pro Ser Thr Gln Gln Val Lys Ser Ser Glu Lys 
            260                 265                 270         


Thr Gln Ile Ala Val Pro Gln Pro Val Ala Pro Ser Tyr Ser Tyr Ala 
        275                 280                 285             


Thr Pro Thr Pro Gln Ala Ser Phe Gln Ser Thr Ser Ala Pro Tyr Pro 
    290                 295                 300                 


Val Ile Lys Glu Leu Val Val Ser Ala Gly Glu Ser Val Gln Ile Thr 
305                 310                 315                 320 


Leu Pro Lys Asn Glu Val Gln Leu Asn Ala Tyr Val Leu Gln Glu Pro 
                325                 330                 335     


Pro Lys Gly Glu Thr Tyr Thr Tyr Asp Trp Gln Leu Ile Thr His Pro 
            340                 345                 350         


Arg Asp Tyr Ser Gly Glu Met Glu Gly Lys His Ser Gln Ile Leu Lys 
        355                 360                 365             


Leu Ser Lys Leu Thr Pro Gly Leu Tyr Glu Phe Lys Val Ile Val Glu 
    370                 375                 380                 


Gly Gln Asn Ala His Gly Glu Gly Tyr Val Asn Val Thr Val Lys Pro 
385                 390                 395                 400 


Glu Pro Arg Lys Asn Arg Pro Pro Ile Ala Ile Val Ser Pro Gln Phe 
                405                 410                 415     


Gln Glu Ile Ser Leu Pro Thr Thr Ser Thr Val Ile Asp Gly Ser Gln 
            420                 425                 430         


Ser Thr Asp Asp Asp Lys Ile Val Gln Tyr His Trp Glu Glu Leu Lys 
        435                 440                 445             


Gly Pro Leu Arg Glu Glu Lys Ile Ser Glu Asp Thr Ala Ile Leu Lys 
    450                 455                 460                 


Leu Ser Lys Leu Val Pro Gly Asn Tyr Thr Phe Ser Leu Thr Val Val 
465                 470                 475                 480 


Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Asn Leu Thr Val Asn 
                485                 490                 495     


Lys Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn Gln Val 
            500                 505                 510         


Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Phe Gly Asn Gln Ser Thr 
        515                 520                 525             


Asp Asp His Gly Ile Thr Ser Tyr Glu Trp Ser Leu Ser Pro Ser Ser 
    530                 535                 540                 


Lys Gly Lys Val Val Glu Met Gln Gly Val Arg Thr Pro Thr Leu Gln 
545                 550                 555                 560 


Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Tyr Gln Leu Thr Val Thr 
                565                 570                 575     


Asp Thr Ile Gly Gln Gln Ala Thr Ala Gln Val Thr Val Ile Val Gln 
            580                 585                 590         


Pro Glu Asn Asn Lys Pro Pro Gln Ala Asp Ala Gly Pro Asp Lys Glu 
        595                 600                 605             


Leu Thr Leu Pro Val Asp Ser Thr Thr Leu Asp Gly Ser Lys Ser Ser 
    610                 615                 620                 


Asp Asp Gln Lys Ile Ile Ser Tyr Leu Trp Glu Lys Thr Gln Gly Pro 
625                 630                 635                 640 


Asp Gly Val Gln Leu Glu Asn Ala Asn Ser Ser Val Ala Thr Val Thr 
                645                 650                 655     


Gly Leu Gln Val Gly Thr Tyr Val Phe Thr Leu Thr Val Lys Asp Glu 
            660                 665                 670         


Arg Asn Leu Gln Ser Gln Ser Ser Val Asn Val Ile Val Lys Glu Glu 
        675                 680                 685             


Ile Asn Lys Pro Pro Ile Ala Lys Ile Thr Gly Asn Val Val Ile Thr 
    690                 695                 700                 


Leu Pro Thr Ser Thr Ala Glu Leu Asp Gly Ser Lys Ser Ser Asp Asp 
705                 710                 715                 720 


Lys Gly Ile Val Ser Tyr Leu Trp Thr Arg Asp Glu Gly Ser Pro Ala 
                725                 730                 735     


Ala Gly Glu Val Leu Asn His Ser Asp His His Pro Ile Leu Phe Leu 
            740                 745                 750         


Ser Asn Leu Val Glu Gly Thr Tyr Thr Phe His Leu Lys Val Thr Asp 
        755                 760                 765             


Ala Lys Gly Glu Ser Asp Thr Asp Arg Thr Thr Val Glu Val Lys Pro 
    770                 775                 780                 


Asp Pro Arg Lys Asn Asn Leu Val Glu Ile Ile Leu Asp Ile Asn Val 
785                 790                 795                 800 


Ser Gln Leu Thr Glu Arg Leu Lys Gly Met Phe Ile Arg Gln Ile Gly 
                805                 810                 815     


Val Leu Leu Gly Val Leu Asp Ser Asp Ile Ile Val Gln Lys Ile Gln 
            820                 825                 830         


Pro Tyr Thr Glu Gln Ser Thr Lys Met Val Phe Phe Val Gln Asn Glu 
        835                 840                 845             


Pro Pro His Gln Ile Phe Lys Gly His Glu Val Ala Ala Met Leu Lys 
    850                 855                 860                 


Ser Glu Leu Arg Lys Gln Lys Ala Asp Phe Leu Ile Phe Arg Ala Leu 
865                 870                 875                 880 


Glu Val Asn Thr Val Thr Cys Gln Leu Asn Cys Ser Asp His Gly His 
                885                 890                 895     


Cys Asp Ser Phe Thr Lys Arg Cys Ile Cys Asp Pro Phe Trp Met Glu 
            900                 905                 910         


Asn Phe Ile Lys Val Gln Leu Arg Asp Gly Asp Ser Asn Cys Glu Trp 
        915                 920                 925             


Ser Val Leu Tyr Val Ile Ile Ala Thr Phe Val Ile Val Val Ala Leu 
    930                 935                 940                 


Gly Ile Leu Ser Trp Thr Val Ile Cys Cys Cys Lys Arg Gln Lys Gly 
945                 950                 955                 960 


Lys Pro Lys Arg Lys Ser Lys Tyr Lys Ile Leu Asp Ala Thr Asp Gln 
                965                 970                 975     


Glu Ser Leu Glu Leu Lys Pro Thr Ser Arg Ala Gly Ile Lys Gln Lys 
            980                 985                 990         


Gly Leu Leu Leu Ser Ser Ser Leu  Met His Ser Glu Ser  Glu Leu Asp 
        995                 1000                 1005             


Ser Asp  Asp Ala Ile Phe Thr  Trp Pro Asp Arg Glu  Lys Gly Lys 
    1010                 1015                 1020             


Leu Leu  His Gly Gln Asn Gly  Ser Val Pro Asn Gly  Gln Thr Pro 
    1025                 1030                 1035             


Leu Lys  Ala Arg Ser Pro Arg  Glu Glu Ile Leu 
    1040                 1045                 


<210>  123
<211>  5692
<212>  DNA
<213>  Homosapiens

<400>  123
gtttccggcc gccgtcgctg tccagggagg ctgaggcgag aggtagctgt ccgggtgggg     60

agcccgcact accttcttcc tcttcctcct cctcctccgg gtgaggggag cgaaggttgg    120

gggtccccga gcccatggac caggaggagg cggaggccgc cgagagccgg ggccccgcta    180

tgtggccctg agccccgtgt actggttctg cctgtctgga gggccatgga gaagaggctg    240

ggagtcaagc caaatcctgc ttcctggatt ttatcaggat attattggca gacatctgcg    300

aagtggttga gaagcctgta cctgttttat acttgctttt gcttcagcgt tctgtggttg    360

tcaacagatg ccagtgagag caggtgccag caggggaaga cacaatttgg agttggcctg    420

agatctgggg gagaaaatca cctctggctt cttgaaggaa ccccctctct ccagtcatgt    480

tgggctgcct gctgccagga ctctgcctgc catgtctttt ggtggctaga agggatgtgc    540

attcaggcag actgcagcag gccccagagc tgccgggctt ttaggacaca ctcctccaat    600

tccatgctgg tgtttttaaa aaaattccaa actgcagatg atttgggctt tctacctgaa    660

gatgatgtac cacatcttct ggggctaggt tggaactggg catcttggag gcagagccca    720

cccagagctg cactcagacc tgctgtatct tccagtgacc agcagagctt aatcaggaag    780

cttcagaaga gaggtagtcc cagtgacgta gttacaccta tagtgacaca gcattctaaa    840

gtgaatgact ccaacgaatt aggtggtctg actaccagtg gctctgcaga ggtccacaag    900

gcgattacaa tttccagtcc cctaaccaca gacctgactg cagagctgtc tggtgggcca    960

aagaatgtat cagtgcaacc tgaaatatca gagggtcttg ctactacgcc cagcactcaa   1020

caagtaaaaa gttctgagaa aacccagatt gctgtccccc agccagtggc tccctcctac   1080

agttatgcta cccctacccc ccaggcctct ttccagagca cctcagcacc atacccagtt   1140

ataaaggaac tggtggtatc tgctggagag agtgtccaga taaccctgcc taagaatgaa   1200

gttcaattaa atgcatatgt tctccaagaa ccacctaaag gagaaaccta cacctacgac   1260

tggcagctga ttactcatcc tagagactac agtggagaaa tggaagggaa acattcccag   1320

atcctcaaac tatcgaagct cactccaggc ctgtatgaat tcaaagtgat tgtagagggt   1380

caaaatgccc atggggaagg ctatgtgaac gtgacagtca agccagagcc ccgtaagaat   1440

cggcccccca ttgctattgt gtcacctcag ttccaggaga tctctttgcc aaccacttct   1500

acagtcattg atggcagtca aagcactgat gatgataaaa tcgttcagta ccattgggaa   1560

gaacttaagg ggcctctaag agaagagaag atttctgaag atacagccat attaaaacta   1620

agtaaactcg tccctgggaa ctacactttc agcttgactg tagtagactc tgatggagct   1680

accaactcta ctactgcaaa cctgacagtg aacaaagctg tggattaccc ccctgtggcc   1740

aacgcaggcc ccaaccaagt gatcaccctg ccccaaaact ccatcaccct ctttgggaac   1800

cagagcactg atgatcatgg catcaccagc tatgagtggt cactcagccc aagcagcaaa   1860

gggaaagtgg tggagatgca gggtgttaga acaccaacct tacagctctc tgcgatgcaa   1920

gaaggagact acacttacca gctcacagtg actgacacaa taggacagca ggccactgct   1980

caagtgactg ttattgtgca acctgaaaac aataagcctc ctcaggcaga tgcaggccca   2040

gataaagagc tgacccttcc tgtggatagc acaaccctgg atggcagcaa gagctcagat   2100

gatcagaaaa ttatctcata tctctgggaa aaaacacagg gacctgatgg ggtgcagctc   2160

gagaatgcta acagcagtgt tgctactgtg actgggctgc aagtggggac ctatgtgttc   2220

accttgactg tcaaagatga gaggaacctg caaagccaga gctctgtgaa tgtcattgtc   2280

aaagaagaaa taaacaaacc acctatagcc aagataactg ggaatgtggt gattacccta   2340

cccacgagca cagcagagct ggatggctct aagtcctcag atgacaaggg aatagtcagc   2400

tacctctgga ctcgagatga ggggagccca gcagcagggg aggtgttaaa tcactctgac   2460

catcacccta tcctttttct ttcaaacctg gttgagggaa cctacacttt tcacctgaaa   2520

gtgaccgatg caaagggtga gagtgacaca gaccggacca ctgtggaggt gaaacctgat   2580

cccaggaaaa acaacctggt ggagatcatc ttggatatca acgtcagtca gctaactgag   2640

aggctgaagg ggatgttcat ccgccagatt ggggtcctcc tgggggtgct ggattccgac   2700

atcattgtgc aaaagattca gccgtacacg gagcagagca ccaaaatggt attttttgtt   2760

caaaacgagc ctccccacca gatcttcaaa ggccatgagg tggcagcgat gctcaagagt   2820

gagctgcgga agcaaaaggc agactttttg atattcagag ccttggaagt caacactgtc   2880

acatgtcagc tgaactgttc cgaccatggc cactgtgact cgttcaccaa acgctgtatc   2940

tgtgaccctt tttggatgga gaatttcatc aaggtgcagc tgagggatgg agacagcaac   3000

tgtgagtgga gcgtgttata tgttatcatt gctacctttg tcattgttgt tgccttggga   3060

atcctgtctt ggactgtgat ctgttgttgt aagaggcaaa aaggaaaacc caagaggaaa   3120

agcaagtaca agatcctgga tgccacggat caggaaagcc tggagctgaa gccaacctcc   3180

cgagcaggta ggggccctgg gtgccagagc ttctaggtct gtgcactctc tctgtggaag   3240

gctgctgtca ctagcccctc ctgagtgtgt cactaacagc ccactgtgct tgcaaagcat   3300

tttgttccct tttgcctgat gaagactgag ggtcagattt gccctgagct gcactggaca   3360

aaatgcctcc aggacccact tcgcgtgcta cttccgcttg gcgggggtgc tgggcctgtt   3420

gttttccttt gcctgggcat tctcctcatg tttcccacct ggagttccgc ttttccaact   3480

gccccaggta gtcagggtca gggaccttgg acttgtctct tactgctgac cagtctgtgc   3540

tttatgggca gagatgagac ccaggcccgt gtctgccagc tgaccacctt tcagccagcc   3600

ttgttctcct gtcttcctat ctttatcatt tggcaagtcc tcagcttctg tcagtgtctt   3660

agggcagata ggagggcatt tccttgcaca aacagtaaga tgactttgag tgatggcact   3720

gggagatcag ggcaggtagt aggccttcct tcctccgctg ggctgggtca cctggcgagg   3780

gtttcactca tcatggatgc catgggacag gtatcattgg tttatgagag ctagactcta   3840

taaagcgatt cctaaacact ctgcaagtag aactattttt atataaagca tttattaaac   3900

acttttcatg cttaaagctt tgtgttaggg agaggctatg ggggtatagg gagtcatcag   3960

acacaggctg tgctctcagt ctagtgaggg agaaaagaca cacagtagca gaagagaaca   4020

ggctcacagc agtctggact ctgcaccaag cagctcgatc caccaacact gtcaaggtgg   4080

agactggagg tggtggggct tgaaatgagc ccaggaaacc agagcagtga gggcgggcgg   4140

ggcatttcac ccaggaatat tgagaatgag ggcctggagg tgaaatgtgc aaaacccacc   4200

cctcacactg cagccaaggt ttttatcatg ttactctgat catgtttttc accccctgac   4260

attcttcaat gacttactat ttctagcaca aaaagctaga acttttggtc tggtagatgt   4320

ggcctttgtg agcttacatc agtttgcttt tctggaatct ttctctttgc tgatctccct   4380

cttttctaaa caagttcttc tggttcatcc agtaatctct ttctttttta aaaatgtggc   4440

gacaaggtct tgctctgtca cccaggctgg agtgcagtgg tatagtcata gctcactgca   4500

acctccagct cctgagctca agtggtcctc ctgcttcagc ctcccaaagc agctgggact   4560

acaggcatgc accaccatac ccagccctag aaagctcttt cttatccctc ccttaacctc   4620

ctcaagttgt gctcaccttt ctctcacatg cctgggtcgg catttctctc gctgtctcat   4680

gattagttat gtttgcctgt ctccccaccc atcagtgaaa tccctgaggg caggggctgt   4740

ctcattcatc tgtggatatg gagcgggacc actatgtgcc aggccctgtg ccagacactg   4800

cttatattgt ggtgaatcaa acggacagac ttcactcttg tgtagcttat gtcagacaga   4860

cattaagcaa actcacaaat acataaaata tgctcataaa aggcctttat gaagaaaaac   4920

acttaagctg agacctggat aagtgggagc tagccagata aagctgcagg aaatagcatt   4980

ccaggcaaag gaacaaaact ggtgcagacc cagctgctag aaggagcaga gagcatttga   5040

ggaggtagaa gaaggtgaca tgatggacag gttcaccttc ccacagagta aggggtgagt   5100

gacccaaggc tcaatggatg agcagggtcc ctgctgagga cttctcttga gtacaatggg   5160

gagccactga tagcttttta aggggatgaa tggtgggatt tggtttacat ttattattat   5220

ttgagacaga gtctcactct tatcacccag gcaggagtgc agtggtgcga tcaaggccca   5280

ctgcagtctt gacctcctgg gctcaggtga tccttccacc tcagcttcct aagtagctgg   5340

gaccacaggc atgcgccacc atccccaggt ttttttgttg ttgttgttgt tgttttgtat   5400

ttttggtaga gacggggttt catcatgttg cctaggctgt tcttgaactc ctgggcttaa   5460

gtgatctgcc tgccttggtc tcctaaagtg ctgggattat aggtgtgagc catggcaccc   5520

ggtcttggtt tatattttaa aaagacaact gtgtagctgg gcgtggtggt gggtgcctgt   5580

aatcccagct actcgagagg ccaaggcagg agaattgcta gaacctgggg gtgtgaaggt   5640

ttcagtgaac tgagatcact ccaacctggg caataaagcc agactctgtc tc           5692


<210>  124
<211>  996
<212>  PRT
<213>  Homosapiens

<400>  124

Met Glu Lys Arg Leu Gly Val Lys Pro Asn Pro Ala Ser Trp Ile Leu 
1               5                   10                  15      


Ser Gly Tyr Tyr Trp Gln Thr Ser Ala Lys Trp Leu Arg Ser Leu Tyr 
            20                  25                  30          


Leu Phe Tyr Thr Cys Phe Cys Phe Ser Val Leu Trp Leu Ser Thr Asp 
        35                  40                  45              


Ala Ser Glu Ser Arg Cys Gln Gln Gly Lys Thr Gln Phe Gly Val Gly 
    50                  55                  60                  


Leu Arg Ser Gly Gly Glu Asn His Leu Trp Leu Leu Glu Gly Thr Pro 
65                  70                  75                  80  


Ser Leu Gln Ser Cys Trp Ala Ala Cys Cys Gln Asp Ser Ala Cys His 
                85                  90                  95      


Val Phe Trp Trp Leu Glu Gly Met Cys Ile Gln Ala Asp Cys Ser Arg 
            100                 105                 110         


Pro Gln Ser Cys Arg Ala Phe Arg Thr His Ser Ser Asn Ser Met Leu 
        115                 120                 125             


Val Phe Leu Lys Lys Phe Gln Thr Ala Asp Asp Leu Gly Phe Leu Pro 
    130                 135                 140                 


Glu Asp Asp Val Pro His Leu Leu Gly Leu Gly Trp Asn Trp Ala Ser 
145                 150                 155                 160 


Trp Arg Gln Ser Pro Pro Arg Ala Ala Leu Arg Pro Ala Val Ser Ser 
                165                 170                 175     


Ser Asp Gln Gln Ser Leu Ile Arg Lys Leu Gln Lys Arg Gly Ser Pro 
            180                 185                 190         


Ser Asp Val Val Thr Pro Ile Val Thr Gln His Ser Lys Val Asn Asp 
        195                 200                 205             


Ser Asn Glu Leu Gly Gly Leu Thr Thr Ser Gly Ser Ala Glu Val His 
    210                 215                 220                 


Lys Ala Ile Thr Ile Ser Ser Pro Leu Thr Thr Asp Leu Thr Ala Glu 
225                 230                 235                 240 


Leu Ser Gly Gly Pro Lys Asn Val Ser Val Gln Pro Glu Ile Ser Glu 
                245                 250                 255     


Gly Leu Ala Thr Thr Pro Ser Thr Gln Gln Val Lys Ser Ser Glu Lys 
            260                 265                 270         


Thr Gln Ile Ala Val Pro Gln Pro Val Ala Pro Ser Tyr Ser Tyr Ala 
        275                 280                 285             


Thr Pro Thr Pro Gln Ala Ser Phe Gln Ser Thr Ser Ala Pro Tyr Pro 
    290                 295                 300                 


Val Ile Lys Glu Leu Val Val Ser Ala Gly Glu Ser Val Gln Ile Thr 
305                 310                 315                 320 


Leu Pro Lys Asn Glu Val Gln Leu Asn Ala Tyr Val Leu Gln Glu Pro 
                325                 330                 335     


Pro Lys Gly Glu Thr Tyr Thr Tyr Asp Trp Gln Leu Ile Thr His Pro 
            340                 345                 350         


Arg Asp Tyr Ser Gly Glu Met Glu Gly Lys His Ser Gln Ile Leu Lys 
        355                 360                 365             


Leu Ser Lys Leu Thr Pro Gly Leu Tyr Glu Phe Lys Val Ile Val Glu 
    370                 375                 380                 


Gly Gln Asn Ala His Gly Glu Gly Tyr Val Asn Val Thr Val Lys Pro 
385                 390                 395                 400 


Glu Pro Arg Lys Asn Arg Pro Pro Ile Ala Ile Val Ser Pro Gln Phe 
                405                 410                 415     


Gln Glu Ile Ser Leu Pro Thr Thr Ser Thr Val Ile Asp Gly Ser Gln 
            420                 425                 430         


Ser Thr Asp Asp Asp Lys Ile Val Gln Tyr His Trp Glu Glu Leu Lys 
        435                 440                 445             


Gly Pro Leu Arg Glu Glu Lys Ile Ser Glu Asp Thr Ala Ile Leu Lys 
    450                 455                 460                 


Leu Ser Lys Leu Val Pro Gly Asn Tyr Thr Phe Ser Leu Thr Val Val 
465                 470                 475                 480 


Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Asn Leu Thr Val Asn 
                485                 490                 495     


Lys Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn Gln Val 
            500                 505                 510         


Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Phe Gly Asn Gln Ser Thr 
        515                 520                 525             


Asp Asp His Gly Ile Thr Ser Tyr Glu Trp Ser Leu Ser Pro Ser Ser 
    530                 535                 540                 


Lys Gly Lys Val Val Glu Met Gln Gly Val Arg Thr Pro Thr Leu Gln 
545                 550                 555                 560 


Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Tyr Gln Leu Thr Val Thr 
                565                 570                 575     


Asp Thr Ile Gly Gln Gln Ala Thr Ala Gln Val Thr Val Ile Val Gln 
            580                 585                 590         


Pro Glu Asn Asn Lys Pro Pro Gln Ala Asp Ala Gly Pro Asp Lys Glu 
        595                 600                 605             


Leu Thr Leu Pro Val Asp Ser Thr Thr Leu Asp Gly Ser Lys Ser Ser 
    610                 615                 620                 


Asp Asp Gln Lys Ile Ile Ser Tyr Leu Trp Glu Lys Thr Gln Gly Pro 
625                 630                 635                 640 


Asp Gly Val Gln Leu Glu Asn Ala Asn Ser Ser Val Ala Thr Val Thr 
                645                 650                 655     


Gly Leu Gln Val Gly Thr Tyr Val Phe Thr Leu Thr Val Lys Asp Glu 
            660                 665                 670         


Arg Asn Leu Gln Ser Gln Ser Ser Val Asn Val Ile Val Lys Glu Glu 
        675                 680                 685             


Ile Asn Lys Pro Pro Ile Ala Lys Ile Thr Gly Asn Val Val Ile Thr 
    690                 695                 700                 


Leu Pro Thr Ser Thr Ala Glu Leu Asp Gly Ser Lys Ser Ser Asp Asp 
705                 710                 715                 720 


Lys Gly Ile Val Ser Tyr Leu Trp Thr Arg Asp Glu Gly Ser Pro Ala 
                725                 730                 735     


Ala Gly Glu Val Leu Asn His Ser Asp His His Pro Ile Leu Phe Leu 
            740                 745                 750         


Ser Asn Leu Val Glu Gly Thr Tyr Thr Phe His Leu Lys Val Thr Asp 
        755                 760                 765             


Ala Lys Gly Glu Ser Asp Thr Asp Arg Thr Thr Val Glu Val Lys Pro 
    770                 775                 780                 


Asp Pro Arg Lys Asn Asn Leu Val Glu Ile Ile Leu Asp Ile Asn Val 
785                 790                 795                 800 


Ser Gln Leu Thr Glu Arg Leu Lys Gly Met Phe Ile Arg Gln Ile Gly 
                805                 810                 815     


Val Leu Leu Gly Val Leu Asp Ser Asp Ile Ile Val Gln Lys Ile Gln 
            820                 825                 830         


Pro Tyr Thr Glu Gln Ser Thr Lys Met Val Phe Phe Val Gln Asn Glu 
        835                 840                 845             


Pro Pro His Gln Ile Phe Lys Gly His Glu Val Ala Ala Met Leu Lys 
    850                 855                 860                 


Ser Glu Leu Arg Lys Gln Lys Ala Asp Phe Leu Ile Phe Arg Ala Leu 
865                 870                 875                 880 


Glu Val Asn Thr Val Thr Cys Gln Leu Asn Cys Ser Asp His Gly His 
                885                 890                 895     


Cys Asp Ser Phe Thr Lys Arg Cys Ile Cys Asp Pro Phe Trp Met Glu 
            900                 905                 910         


Asn Phe Ile Lys Val Gln Leu Arg Asp Gly Asp Ser Asn Cys Glu Trp 
        915                 920                 925             


Ser Val Leu Tyr Val Ile Ile Ala Thr Phe Val Ile Val Val Ala Leu 
    930                 935                 940                 


Gly Ile Leu Ser Trp Thr Val Ile Cys Cys Cys Lys Arg Gln Lys Gly 
945                 950                 955                 960 


Lys Pro Lys Arg Lys Ser Lys Tyr Lys Ile Leu Asp Ala Thr Asp Gln 
                965                 970                 975     


Glu Ser Leu Glu Leu Lys Pro Thr Ser Arg Ala Gly Arg Gly Pro Gly 
            980                 985                 990         


Cys Gln Ser Phe 
        995     


<210>  125
<211>  3446
<212>  DNA
<213>  Homosapiens

<400>  125
agccaggagt gggcaacgcg gcgtgagcag cggcccgagg ctcccggagc atcgcgctgg     60

gagaagactt cgccgctcgg ggccgcagcc tgtgtgatct catcgccgcc ctgtcgtgac    120

ttcatcaatg tcgtgttgtg acctggctgc ggcgggacag ttgggcaagg cgagcatcat    180

ggcctcggat tgcgagccag ctctgaacca ggcagagggc cgaaacccca ccctggagcg    240

ctacctggga gccctccgtg aggccaagaa tgacagcgag cagtttgcag ccctgctgct    300

agtgaccaag gcagtcaaag caggtgacat agatgccaaa actcggcggc ggatcttcga    360

tgctgtcggc ttcaccttcc ccaatcgtct cctgaccacc aaggaggcgc cggatggctg    420

ccctgaccat gttctgcggg ctttgggtgt ggccctgctg gcctgcttct gcagtgaccc    480

tgaactggcc gcccatcccc aagtcctgaa caagattccc attcttagca ccttcctcac    540

agcccggggg gacccggacg atgctgcccg ccgctccatg attgatgaca cctaccagtg    600

cctgacggct gtagcaggca cacccagagg gcctcggcac ctcattgctg gtggcaccgt    660

gtctgcccta tgccaggcat acctggggca cggctatggc tttgaccagg ccctggcact    720

cctggtgggg ctgctggctg ctgccgagac acagtgctgg aaggaggcgg agcccgacct    780

gctggccgtg ttgcggggcc tcagtgagga tttccagaaa gctgaggatg ccagcaagtt    840

tgagctctgc cagctgctgc ccctcttttt gcccccgaca accgtgcccc ctgaatgcta    900

ccgggatctg caggccgggc tggcacgcat cctgggaagc aagctgagct cctggcagcg    960

caaccctgca ctgaagctgg cagcccgcct ggcacacgcc tgcggctccg actggatccc   1020

ggcgggcagc tccgggagca agttcctggc cctgctggtg aatctggcgt gcgtggaagt   1080

gcggctggca ctggaggaga cgggcacgga ggtgaaagag gatgtggtga ccgcctgcta   1140

tgccctcatg gagttgggga tccaggaatg cactcgctgt gagcagtcac tgcttaagga   1200

gccacagaag gtgcagctcg tgagcgtcat gaaggaggcc ataggggctg ttatccacta   1260

cctgctgcag gtggggtcag agaagcagaa ggagcccttt gtgtttgcct cggtgcggat   1320

cctgggtgcc tggctggccg aggagacctc atccttgcgt aaggaggtgt gccagctgct   1380

gcccttcctc gtccgctatg ccaagaccct ctacgaggag gccgaggagg ccaatgacct   1440

ttcccagcag gtggccaacc tggccatctc ccccaccacc ccagggccca cctggccagg   1500

agacgctctc cggctcctcc tgcctggctg gtgccacctg accgttgaag atgggccccg   1560

ggagatcctg atcaaggaag gggccccctc gcttctgtgc aagtatttcc tgcagcagtg   1620

ggaactcaca tcccctggcc acgacacctc ggtgctgcct gacagcgtgg agattggcct   1680

gcagacctgc tgccacatct tcctcaacct cgtggtcacc gcaccggggc tgatcaagcg   1740

tgacgcctgc ttcacatctc taatgaacac cctcatgacg tcgctaccag cactagtgca   1800

gcaacaggga aggctgcttc tggctgctaa tgtggccacc ctggggctcc tcatggcccg   1860

gctccttagc acctctccag ctcttcaggg aacaccagca tcccgagggt tcttcgcagc   1920

tgccatcctc ttcctatcac agtcccacgt ggcgcgggcc accccgggct cagaccaggc   1980

agtgctagcc ctgtcccctg agtatgaggg catctgggcc gacctgcagg agctctggtt   2040

cctgggcatg caggccttca ccggctgtgt gcctctgctg ccctggctgg cccccgctgc   2100

cctgcgctcc cgctggccgc aggagctgct ccagctgcta ggcagtgtca gccccaactc   2160

tgtcaagccc gagatggtgg ccgcctatca gggtgtcctg gtggagctgg cgcgggccaa   2220

ccggctgtgc cgggaggcca tgaggctgca ggcgggcgag gagacggcca gccactaccg   2280

catggctgcc ttggagcagt gcctgtcaga gccctgaggg gtgtccaccg gggacagacc   2340

caggggcggg cagagaggga aggagggagg aggcatcttc cctgaagccc ccaatctggc   2400

ccccccctcc ccagacttcc tccccaaaac accccagctt tctggctttt ctgagggcaa   2460

gggcatggtg cccacccctc aagtgtaagg aactgcgttc cgcccctcag gcccccatgg   2520

gggcagggat cggcttggaa atcaacgtgg ttgtccccgc caggccgggg aaggttggag   2580

cagcccccag ggaggggggc actaggtgtc attgtgcccg atgtctggct cccctgcagg   2640

agggaggctc cagggtaaga cagggctggc aggagcagac tgcctcagcc catgtgccct   2700

gccggccagg gcgtgggctc ccctcggctg tggtgcctcc tctggccccc caggtccacg   2760

tcctttaaat tggccctttg gctcttgccc ttggctccct tgggcagaca gcaggcttag   2820

gccattgata tcgcagttct tcctatcagc ttcagtgacc cagggtctga actgcctcca   2880

tcctagggca acctggggca gacaggcctg gtggggggtg gggaaacctc cttccacctg   2940

agcttgcttg aagggaccca gagtctttgg gcccagatct ttaaaccttt gtgtcgtgtt   3000

gcagcagagt gacgatgggg gttggggggt tatttatttt gcctgtcctt atccctgctt   3060

ggacacctga gcatctgatt cctgtccccc tggtgccatc tggcctggct ggagccagga   3120

acaggaggga cacttcccca gaatccgcat gtttccccag tgattacact ccactgccac   3180

cgtggtgcct ggctttaact cccacccctg ctatgactcc tctctgcaga gacgcgactg   3240

gcggctccag cagggactac ctttcttata aacccagggg gaccacacac acacacacac   3300

acacacacac acacacacac acacacacac acactcttga tcccttgctt ccctccccca   3360

gtgcgttctg tgatcgccaa gttcaaagct gtgcacatgt ggacactcaa taaatgttca   3420

ttggtgacga gaaaaaaaaa aaaaaa                                        3446


<210>  126
<211>  729
<212>  PRT
<213>  Homosapiens

<400>  126

Met Ser Cys Cys Asp Leu Ala Ala Ala Gly Gln Leu Gly Lys Ala Ser 
1               5                   10                  15      


Ile Met Ala Ser Asp Cys Glu Pro Ala Leu Asn Gln Ala Glu Gly Arg 
            20                  25                  30          


Asn Pro Thr Leu Glu Arg Tyr Leu Gly Ala Leu Arg Glu Ala Lys Asn 
        35                  40                  45              


Asp Ser Glu Gln Phe Ala Ala Leu Leu Leu Val Thr Lys Ala Val Lys 
    50                  55                  60                  


Ala Gly Asp Ile Asp Ala Lys Thr Arg Arg Arg Ile Phe Asp Ala Val 
65                  70                  75                  80  


Gly Phe Thr Phe Pro Asn Arg Leu Leu Thr Thr Lys Glu Ala Pro Asp 
                85                  90                  95      


Gly Cys Pro Asp His Val Leu Arg Ala Leu Gly Val Ala Leu Leu Ala 
            100                 105                 110         


Cys Phe Cys Ser Asp Pro Glu Leu Ala Ala His Pro Gln Val Leu Asn 
        115                 120                 125             


Lys Ile Pro Ile Leu Ser Thr Phe Leu Thr Ala Arg Gly Asp Pro Asp 
    130                 135                 140                 


Asp Ala Ala Arg Arg Ser Met Ile Asp Asp Thr Tyr Gln Cys Leu Thr 
145                 150                 155                 160 


Ala Val Ala Gly Thr Pro Arg Gly Pro Arg His Leu Ile Ala Gly Gly 
                165                 170                 175     


Thr Val Ser Ala Leu Cys Gln Ala Tyr Leu Gly His Gly Tyr Gly Phe 
            180                 185                 190         


Asp Gln Ala Leu Ala Leu Leu Val Gly Leu Leu Ala Ala Ala Glu Thr 
        195                 200                 205             


Gln Cys Trp Lys Glu Ala Glu Pro Asp Leu Leu Ala Val Leu Arg Gly 
    210                 215                 220                 


Leu Ser Glu Asp Phe Gln Lys Ala Glu Asp Ala Ser Lys Phe Glu Leu 
225                 230                 235                 240 


Cys Gln Leu Leu Pro Leu Phe Leu Pro Pro Thr Thr Val Pro Pro Glu 
                245                 250                 255     


Cys Tyr Arg Asp Leu Gln Ala Gly Leu Ala Arg Ile Leu Gly Ser Lys 
            260                 265                 270         


Leu Ser Ser Trp Gln Arg Asn Pro Ala Leu Lys Leu Ala Ala Arg Leu 
        275                 280                 285             


Ala His Ala Cys Gly Ser Asp Trp Ile Pro Ala Gly Ser Ser Gly Ser 
    290                 295                 300                 


Lys Phe Leu Ala Leu Leu Val Asn Leu Ala Cys Val Glu Val Arg Leu 
305                 310                 315                 320 


Ala Leu Glu Glu Thr Gly Thr Glu Val Lys Glu Asp Val Val Thr Ala 
                325                 330                 335     


Cys Tyr Ala Leu Met Glu Leu Gly Ile Gln Glu Cys Thr Arg Cys Glu 
            340                 345                 350         


Gln Ser Leu Leu Lys Glu Pro Gln Lys Val Gln Leu Val Ser Val Met 
        355                 360                 365             


Lys Glu Ala Ile Gly Ala Val Ile His Tyr Leu Leu Gln Val Gly Ser 
    370                 375                 380                 


Glu Lys Gln Lys Glu Pro Phe Val Phe Ala Ser Val Arg Ile Leu Gly 
385                 390                 395                 400 


Ala Trp Leu Ala Glu Glu Thr Ser Ser Leu Arg Lys Glu Val Cys Gln 
                405                 410                 415     


Leu Leu Pro Phe Leu Val Arg Tyr Ala Lys Thr Leu Tyr Glu Glu Ala 
            420                 425                 430         


Glu Glu Ala Asn Asp Leu Ser Gln Gln Val Ala Asn Leu Ala Ile Ser 
        435                 440                 445             


Pro Thr Thr Pro Gly Pro Thr Trp Pro Gly Asp Ala Leu Arg Leu Leu 
    450                 455                 460                 


Leu Pro Gly Trp Cys His Leu Thr Val Glu Asp Gly Pro Arg Glu Ile 
465                 470                 475                 480 


Leu Ile Lys Glu Gly Ala Pro Ser Leu Leu Cys Lys Tyr Phe Leu Gln 
                485                 490                 495     


Gln Trp Glu Leu Thr Ser Pro Gly His Asp Thr Ser Val Leu Pro Asp 
            500                 505                 510         


Ser Val Glu Ile Gly Leu Gln Thr Cys Cys His Ile Phe Leu Asn Leu 
        515                 520                 525             


Val Val Thr Ala Pro Gly Leu Ile Lys Arg Asp Ala Cys Phe Thr Ser 
    530                 535                 540                 


Leu Met Asn Thr Leu Met Thr Ser Leu Pro Ala Leu Val Gln Gln Gln 
545                 550                 555                 560 


Gly Arg Leu Leu Leu Ala Ala Asn Val Ala Thr Leu Gly Leu Leu Met 
                565                 570                 575     


Ala Arg Leu Leu Ser Thr Ser Pro Ala Leu Gln Gly Thr Pro Ala Ser 
            580                 585                 590         


Arg Gly Phe Phe Ala Ala Ala Ile Leu Phe Leu Ser Gln Ser His Val 
        595                 600                 605             


Ala Arg Ala Thr Pro Gly Ser Asp Gln Ala Val Leu Ala Leu Ser Pro 
    610                 615                 620                 


Glu Tyr Glu Gly Ile Trp Ala Asp Leu Gln Glu Leu Trp Phe Leu Gly 
625                 630                 635                 640 


Met Gln Ala Phe Thr Gly Cys Val Pro Leu Leu Pro Trp Leu Ala Pro 
                645                 650                 655     


Ala Ala Leu Arg Ser Arg Trp Pro Gln Glu Leu Leu Gln Leu Leu Gly 
            660                 665                 670         


Ser Val Ser Pro Asn Ser Val Lys Pro Glu Met Val Ala Ala Tyr Gln 
        675                 680                 685             


Gly Val Leu Val Glu Leu Ala Arg Ala Asn Arg Leu Cys Arg Glu Ala 
    690                 695                 700                 


Met Arg Leu Gln Ala Gly Glu Glu Thr Ala Ser His Tyr Arg Met Ala 
705                 710                 715                 720 


Ala Leu Glu Gln Cys Leu Ser Glu Pro 
                725                 


<210>  127
<211>  3378
<212>  DNA
<213>  Homosapiens

<400>  127
agccaggagt gggcaacgcg gcgtgagcag cggcccgagg ctcccggagc atcgcgctgg     60

gagaagactt cgccgctcgg ggccgcagcc tgttgggcaa ggcgagcatc atggcctcgg    120

attgcgagcc agctctgaac caggcagagg gccgaaaccc caccctggag cgctacctgg    180

gagccctccg tgaggccaag aatgacagcg agcagtttgc agccctgctg ctagtgacca    240

aggcagtcaa agcaggtgac atagatgcca aaactcggcg gcggatcttc gatgctgtcg    300

gcttcacctt ccccaatcgt ctcctgacca ccaaggaggc gccggatggc tgccctgacc    360

atgttctgcg ggctttgggt gtggccctgc tggcctgctt ctgcagtgac cctgaactgg    420

ccgcccatcc ccaagtcctg aacaagattc ccattcttag caccttcctc acagcccggg    480

gggacccgga cgatgctgcc cgccgctcca tgattgatga cacctaccag tgcctgacgg    540

ctgtagcagg cacacccaga gggcctcggc acctcattgc tggtggcacc gtgtctgccc    600

tatgccaggc atacctgggg cacggctatg gctttgacca ggccctggca ctcctggtgg    660

ggctgctggc tgctgccgag acacagtgct ggaaggaggc ggagcccgac ctgctggccg    720

tgttgcgggg cctcagtgag gatttccaga aagctgagga tgccagcaag tttgagctct    780

gccagctgct gcccctcttt ttgcccccga caaccgtgcc ccctgaatgc taccgggatc    840

tgcaggccgg gctggcacgc atcctgggaa gcaagctgag ctcctggcag cgcaaccctg    900

cactgaagct ggcagcccgc ctggcacacg cctgcggctc cgactggatc ccggcgggca    960

gctccgggag caagttcctg gccctgctgg tgaatctggc gtgcgtggaa gtgcggctgg   1020

cactggagga gacgggcacg gaggtgaaag aggatgtggt gaccgcctgc tatgccctca   1080

tggagttggg gatccaggaa tgcactcgct gtgagcagtc actgcttaag gagccacaga   1140

aggtgcagct cgtgagcgtc atgaaggagg ccataggggc tgttatccac tacctgctgc   1200

aggtggggtc agagaagcag aaggagccct ttgtgtttgc ctcggtgcgg atcctgggtg   1260

cctggctggc cgaggagacc tcatccttgc gtaaggaggt gtgccagctg ctgcccttcc   1320

tcgtccgcta tgccaagacc ctctacgagg aggccgagga ggccaatgac ctttcccagc   1380

aggtggccaa cctggccatc tcccccacca ccccagggcc cacctggcca ggagacgctc   1440

tccggctcct cctgcctggc tggtgccacc tgaccgttga agatgggccc cgggagatcc   1500

tgatcaagga aggggccccc tcgcttctgt gcaagtattt cctgcagcag tgggaactca   1560

catcccctgg ccacgacacc tcggtgctgc ctgacagcgt ggagattggc ctgcagacct   1620

gctgccacat cttcctcaac ctcgtggtca ccgcaccggg gctgatcaag cgtgacgcct   1680

gcttcacatc tctaatgaac accctcatga cgtcgctacc agcactagtg cagcaacagg   1740

gaaggctgct tctggctgct aatgtggcca ccctggggct cctcatggcc cggctcctta   1800

gcacctctcc agctcttcag ggaacaccag catcccgagg gttcttcgca gctgccatcc   1860

tcttcctatc acagtcccac gtggcgcggg ccaccccggg ctcagaccag gcagtgctag   1920

ccctgtcccc tgagtatgag ggcatctggg ccgacctgca ggagctctgg ttcctgggca   1980

tgcaggcctt caccggctgt gtgcctctgc tgccctggct ggcccccgct gccctgcgct   2040

cccgctggcc gcaggagctg ctccagctgc taggcagtgt cagccccaac tctgtcaagc   2100

ccgagatggt ggccgcctat cagggtgtcc tggtggagct ggcgcgggcc aaccggctgt   2160

gccgggaggc catgaggctg caggcgggcg aggagacggc cagccactac cgcatggctg   2220

ccttggagca gtgcctgtca gagccctgag gggtgtccac cggggacaga cccaggggcg   2280

ggcagagagg gaaggaggga ggaggcatct tccctgaagc ccccaatctg gcccccccct   2340

ccccagactt cctccccaaa acaccccagc tttctggctt ttctgagggc aagggcatgg   2400

tgcccacccc tcaagtgtaa ggaactgcgt tccgcccctc aggcccccat gggggcaggg   2460

atcggcttgg aaatcaacgt ggttgtcccc gccaggccgg ggaaggttgg agcagccccc   2520

agggaggggg gcactaggtg tcattgtgcc cgatgtctgg ctcccctgca ggagggaggc   2580

tccagggtaa gacagggctg gcaggagcag actgcctcag cccatgtgcc ctgccggcca   2640

gggcgtgggc tcccctcggc tgtggtgcct cctctggccc cccaggtcca cgtcctttaa   2700

attggccctt tggctcttgc ccttggctcc cttgggcaga cagcaggctt aggccattga   2760

tatcgcagtt cttcctatca gcttcagtga cccagggtct gaactgcctc catcctaggg   2820

caacctgggg cagacaggcc tggtgggggg tggggaaacc tccttccacc tgagcttgct   2880

tgaagggacc cagagtcttt gggcccagat ctttaaacct ttgtgtcgtg ttgcagcaga   2940

gtgacgatgg gggttggggg gttatttatt ttgcctgtcc ttatccctgc ttggacacct   3000

gagcatctga ttcctgtccc cctggtgcca tctggcctgg ctggagccag gaacaggagg   3060

gacacttccc cagaatccgc atgtttcccc agtgattaca ctccactgcc accgtggtgc   3120

ctggctttaa ctcccacccc tgctatgact cctctctgca gagacgcgac tggcggctcc   3180

agcagggact acctttctta taaacccagg gggaccacac acacacacac acacacacac   3240

acacacacac acacacacac acacactctt gatcccttgc ttccctcccc cagtgcgttc   3300

tgtgatcgcc aagttcaaag ctgtgcacat gtggacactc aataaatgtt cattggtgac   3360

gagaaaaaaa aaaaaaaa                                                 3378


<210>  128
<211>  712
<212>  PRT
<213>  Homosapiens

<400>  128

Met Ala Ser Asp Cys Glu Pro Ala Leu Asn Gln Ala Glu Gly Arg Asn 
1               5                   10                  15      


Pro Thr Leu Glu Arg Tyr Leu Gly Ala Leu Arg Glu Ala Lys Asn Asp 
            20                  25                  30          


Ser Glu Gln Phe Ala Ala Leu Leu Leu Val Thr Lys Ala Val Lys Ala 
        35                  40                  45              


Gly Asp Ile Asp Ala Lys Thr Arg Arg Arg Ile Phe Asp Ala Val Gly 
    50                  55                  60                  


Phe Thr Phe Pro Asn Arg Leu Leu Thr Thr Lys Glu Ala Pro Asp Gly 
65                  70                  75                  80  


Cys Pro Asp His Val Leu Arg Ala Leu Gly Val Ala Leu Leu Ala Cys 
                85                  90                  95      


Phe Cys Ser Asp Pro Glu Leu Ala Ala His Pro Gln Val Leu Asn Lys 
            100                 105                 110         


Ile Pro Ile Leu Ser Thr Phe Leu Thr Ala Arg Gly Asp Pro Asp Asp 
        115                 120                 125             


Ala Ala Arg Arg Ser Met Ile Asp Asp Thr Tyr Gln Cys Leu Thr Ala 
    130                 135                 140                 


Val Ala Gly Thr Pro Arg Gly Pro Arg His Leu Ile Ala Gly Gly Thr 
145                 150                 155                 160 


Val Ser Ala Leu Cys Gln Ala Tyr Leu Gly His Gly Tyr Gly Phe Asp 
                165                 170                 175     


Gln Ala Leu Ala Leu Leu Val Gly Leu Leu Ala Ala Ala Glu Thr Gln 
            180                 185                 190         


Cys Trp Lys Glu Ala Glu Pro Asp Leu Leu Ala Val Leu Arg Gly Leu 
        195                 200                 205             


Ser Glu Asp Phe Gln Lys Ala Glu Asp Ala Ser Lys Phe Glu Leu Cys 
    210                 215                 220                 


Gln Leu Leu Pro Leu Phe Leu Pro Pro Thr Thr Val Pro Pro Glu Cys 
225                 230                 235                 240 


Tyr Arg Asp Leu Gln Ala Gly Leu Ala Arg Ile Leu Gly Ser Lys Leu 
                245                 250                 255     


Ser Ser Trp Gln Arg Asn Pro Ala Leu Lys Leu Ala Ala Arg Leu Ala 
            260                 265                 270         


His Ala Cys Gly Ser Asp Trp Ile Pro Ala Gly Ser Ser Gly Ser Lys 
        275                 280                 285             


Phe Leu Ala Leu Leu Val Asn Leu Ala Cys Val Glu Val Arg Leu Ala 
    290                 295                 300                 


Leu Glu Glu Thr Gly Thr Glu Val Lys Glu Asp Val Val Thr Ala Cys 
305                 310                 315                 320 


Tyr Ala Leu Met Glu Leu Gly Ile Gln Glu Cys Thr Arg Cys Glu Gln 
                325                 330                 335     


Ser Leu Leu Lys Glu Pro Gln Lys Val Gln Leu Val Ser Val Met Lys 
            340                 345                 350         


Glu Ala Ile Gly Ala Val Ile His Tyr Leu Leu Gln Val Gly Ser Glu 
        355                 360                 365             


Lys Gln Lys Glu Pro Phe Val Phe Ala Ser Val Arg Ile Leu Gly Ala 
    370                 375                 380                 


Trp Leu Ala Glu Glu Thr Ser Ser Leu Arg Lys Glu Val Cys Gln Leu 
385                 390                 395                 400 


Leu Pro Phe Leu Val Arg Tyr Ala Lys Thr Leu Tyr Glu Glu Ala Glu 
                405                 410                 415     


Glu Ala Asn Asp Leu Ser Gln Gln Val Ala Asn Leu Ala Ile Ser Pro 
            420                 425                 430         


Thr Thr Pro Gly Pro Thr Trp Pro Gly Asp Ala Leu Arg Leu Leu Leu 
        435                 440                 445             


Pro Gly Trp Cys His Leu Thr Val Glu Asp Gly Pro Arg Glu Ile Leu 
    450                 455                 460                 


Ile Lys Glu Gly Ala Pro Ser Leu Leu Cys Lys Tyr Phe Leu Gln Gln 
465                 470                 475                 480 


Trp Glu Leu Thr Ser Pro Gly His Asp Thr Ser Val Leu Pro Asp Ser 
                485                 490                 495     


Val Glu Ile Gly Leu Gln Thr Cys Cys His Ile Phe Leu Asn Leu Val 
            500                 505                 510         


Val Thr Ala Pro Gly Leu Ile Lys Arg Asp Ala Cys Phe Thr Ser Leu 
        515                 520                 525             


Met Asn Thr Leu Met Thr Ser Leu Pro Ala Leu Val Gln Gln Gln Gly 
    530                 535                 540                 


Arg Leu Leu Leu Ala Ala Asn Val Ala Thr Leu Gly Leu Leu Met Ala 
545                 550                 555                 560 


Arg Leu Leu Ser Thr Ser Pro Ala Leu Gln Gly Thr Pro Ala Ser Arg 
                565                 570                 575     


Gly Phe Phe Ala Ala Ala Ile Leu Phe Leu Ser Gln Ser His Val Ala 
            580                 585                 590         


Arg Ala Thr Pro Gly Ser Asp Gln Ala Val Leu Ala Leu Ser Pro Glu 
        595                 600                 605             


Tyr Glu Gly Ile Trp Ala Asp Leu Gln Glu Leu Trp Phe Leu Gly Met 
    610                 615                 620                 


Gln Ala Phe Thr Gly Cys Val Pro Leu Leu Pro Trp Leu Ala Pro Ala 
625                 630                 635                 640 


Ala Leu Arg Ser Arg Trp Pro Gln Glu Leu Leu Gln Leu Leu Gly Ser 
                645                 650                 655     


Val Ser Pro Asn Ser Val Lys Pro Glu Met Val Ala Ala Tyr Gln Gly 
            660                 665                 670         


Val Leu Val Glu Leu Ala Arg Ala Asn Arg Leu Cys Arg Glu Ala Met 
        675                 680                 685             


Arg Leu Gln Ala Gly Glu Glu Thr Ala Ser His Tyr Arg Met Ala Ala 
    690                 695                 700                 


Leu Glu Gln Cys Leu Ser Glu Pro 
705                 710         


<210>  129
<211>  3718
<212>  DNA
<213>  Homosapiens

<400>  129
agccaggagt gggcaacgcg gcgtgagcag cggcccgagg ctcccggagc atcgcgctgg     60

gagaagactt cgccgctcgg ggccgcagcc tggtgagctc agcccccttc gggccctccc    120

ctgcatccca gccggggcct ctccgagccg gcgctgatcg atgccgacac accccgggga    180

ccctatcgcg actccatcgc gccatatcgc gacaccatcg tgccctgtcg agactccatt    240

ttgtcacagc ccttttcaat atatatcttt ttttttttta atttgccctg tcatctttgg    300

gggctgtctc ccatgtcgtg attttgacgt gatctctccg tgacatcacc gcgccatcgt    360

gaagtgtgat ctcatcgccg ccctgtcgtg acttcatcaa tgtcgtgttg tgacctggct    420

gcggcgggac agttgggcaa ggcgagcatc atggcctcgg attgcgagcc agctctgaac    480

caggcagagg gccgaaaccc caccctggag cgctacctgg gagccctccg tgaggccaag    540

aatgacagcg agcagtttgc agccctgctg ctagtgacca aggcagtcaa agcaggtgac    600

atagatgcca aaactcggcg gcggatcttc gatgctgtcg gcttcacctt ccccaatcgt    660

ctcctgacca ccaaggaggc gccggatggc tgccctgacc atgttctgcg ggctttgggt    720

gtggccctgc tggcctgctt ctgcagtgac cctgaactgg ccgcccatcc ccaagtcctg    780

aacaagattc ccattcttag caccttcctc acagcccggg gggacccgga cgatgctgcc    840

cgccgctcca tgattgatga cacctaccag tgcctgacgg ctgtagcagg cacacccaga    900

gggcctcggc acctcattgc tggtggcacc gtgtctgccc tatgccaggc atacctgggg    960

cacggctatg gctttgacca ggccctggca ctcctggtgg ggctgctggc tgctgccgag   1020

acacagtgct ggaaggaggc ggagcccgac ctgctggccg tgttgcgggg cctcagtgag   1080

gatttccaga aagctgagga tgccagcaag tttgagctct gccagctgct gcccctcttt   1140

ttgcccccga caaccgtgcc ccctgaatgc taccgggatc tgcaggccgg gctggcacgc   1200

atcctgggaa gcaagctgag ctcctggcag cgcaaccctg cactgaagct ggcagcccgc   1260

ctggcacacg cctgcggctc cgactggatc ccggcgggca gctccgggag caagttcctg   1320

gccctgctgg tgaatctggc gtgcgtggaa gtgcggctgg cactggagga gacgggcacg   1380

gaggtgaaag aggatgtggt gaccgcctgc tatgccctca tggagttggg gatccaggaa   1440

tgcactcgct gtgagcagtc actgcttaag gagccacaga aggtgcagct cgtgagcgtc   1500

atgaaggagg ccataggggc tgttatccac tacctgctgc aggtggggtc agagaagcag   1560

aaggagccct ttgtgtttgc ctcggtgcgg atcctgggtg cctggctggc cgaggagacc   1620

tcatccttgc gtaaggaggt gtgccagctg ctgcccttcc tcgtccgcta tgccaagacc   1680

ctctacgagg aggccgagga ggccaatgac ctttcccagc aggtggccaa cctggccatc   1740

tcccccacca ccccagggcc cacctggcca ggagacgctc tccggctcct cctgcctggc   1800

tggtgccacc tgaccgttga agatgggccc cgggagatcc tgatcaagga aggggccccc   1860

tcgcttctgt gcaagtattt cctgcagcag tgggaactca catcccctgg ccacgacacc   1920

tcggtgctgc ctgacagcgt ggagattggc ctgcagacct gctgccacat cttcctcaac   1980

ctcgtggtca ccgcaccggg gctgatcaag cgtgacgcct gcttcacatc tctaatgaac   2040

accctcatga cgtcgctacc agcactagtg cagcaacagg gaaggctgct tctggctgct   2100

aatgtggcca ccctggggct cctcatggcc cggctcctta gcacctctcc agctcttcag   2160

ggaacaccag catcccgagg gttcttcgca gctgccatcc tcttcctatc acagtcccac   2220

gtggcgcggg ccaccccggg ctcagaccag gcagtgctag ccctgtcccc tgagtatgag   2280

ggcatctggg ccgacctgca ggagctctgg ttcctgggca tgcaggcctt caccggctgt   2340

gtgcctctgc tgccctggct ggcccccgct gccctgcgct cccgctggcc gcaggagctg   2400

ctccagctgc taggcagtgt cagccccaac tctgtcaagc ccgagatggt ggccgcctat   2460

cagggtgtcc tggtggagct ggcgcgggcc aaccggctgt gccgggaggc catgaggctg   2520

caggcgggcg aggagacggc cagccactac cgcatggctg ccttggagca gtgcctgtca   2580

gagccctgag gggtgtccac cggggacaga cccaggggcg ggcagagagg gaaggaggga   2640

ggaggcatct tccctgaagc ccccaatctg gcccccccct ccccagactt cctccccaaa   2700

acaccccagc tttctggctt ttctgagggc aagggcatgg tgcccacccc tcaagtgtaa   2760

ggaactgcgt tccgcccctc aggcccccat gggggcaggg atcggcttgg aaatcaacgt   2820

ggttgtcccc gccaggccgg ggaaggttgg agcagccccc agggaggggg gcactaggtg   2880

tcattgtgcc cgatgtctgg ctcccctgca ggagggaggc tccagggtaa gacagggctg   2940

gcaggagcag actgcctcag cccatgtgcc ctgccggcca gggcgtgggc tcccctcggc   3000

tgtggtgcct cctctggccc cccaggtcca cgtcctttaa attggccctt tggctcttgc   3060

ccttggctcc cttgggcaga cagcaggctt aggccattga tatcgcagtt cttcctatca   3120

gcttcagtga cccagggtct gaactgcctc catcctaggg caacctgggg cagacaggcc   3180

tggtgggggg tggggaaacc tccttccacc tgagcttgct tgaagggacc cagagtcttt   3240

gggcccagat ctttaaacct ttgtgtcgtg ttgcagcaga gtgacgatgg gggttggggg   3300

gttatttatt ttgcctgtcc ttatccctgc ttggacacct gagcatctga ttcctgtccc   3360

cctggtgcca tctggcctgg ctggagccag gaacaggagg gacacttccc cagaatccgc   3420

atgtttcccc agtgattaca ctccactgcc accgtggtgc ctggctttaa ctcccacccc   3480

tgctatgact cctctctgca gagacgcgac tggcggctcc agcagggact acctttctta   3540

taaacccagg gggaccacac acacacacac acacacacac acacacacac acacacacac   3600

acacactctt gatcccttgc ttccctcccc cagtgcgttc tgtgatcgcc aagttcaaag   3660

ctgtgcacat gtggacactc aataaatgtt cattggtgac gagaaaaaaa aaaaaaaa     3718


<210>  130
<211>  729
<212>  PRT
<213>  Homosapiens

<400>  130

Met Ser Cys Cys Asp Leu Ala Ala Ala Gly Gln Leu Gly Lys Ala Ser 
1               5                   10                  15      


Ile Met Ala Ser Asp Cys Glu Pro Ala Leu Asn Gln Ala Glu Gly Arg 
            20                  25                  30          


Asn Pro Thr Leu Glu Arg Tyr Leu Gly Ala Leu Arg Glu Ala Lys Asn 
        35                  40                  45              


Asp Ser Glu Gln Phe Ala Ala Leu Leu Leu Val Thr Lys Ala Val Lys 
    50                  55                  60                  


Ala Gly Asp Ile Asp Ala Lys Thr Arg Arg Arg Ile Phe Asp Ala Val 
65                  70                  75                  80  


Gly Phe Thr Phe Pro Asn Arg Leu Leu Thr Thr Lys Glu Ala Pro Asp 
                85                  90                  95      


Gly Cys Pro Asp His Val Leu Arg Ala Leu Gly Val Ala Leu Leu Ala 
            100                 105                 110         


Cys Phe Cys Ser Asp Pro Glu Leu Ala Ala His Pro Gln Val Leu Asn 
        115                 120                 125             


Lys Ile Pro Ile Leu Ser Thr Phe Leu Thr Ala Arg Gly Asp Pro Asp 
    130                 135                 140                 


Asp Ala Ala Arg Arg Ser Met Ile Asp Asp Thr Tyr Gln Cys Leu Thr 
145                 150                 155                 160 


Ala Val Ala Gly Thr Pro Arg Gly Pro Arg His Leu Ile Ala Gly Gly 
                165                 170                 175     


Thr Val Ser Ala Leu Cys Gln Ala Tyr Leu Gly His Gly Tyr Gly Phe 
            180                 185                 190         


Asp Gln Ala Leu Ala Leu Leu Val Gly Leu Leu Ala Ala Ala Glu Thr 
        195                 200                 205             


Gln Cys Trp Lys Glu Ala Glu Pro Asp Leu Leu Ala Val Leu Arg Gly 
    210                 215                 220                 


Leu Ser Glu Asp Phe Gln Lys Ala Glu Asp Ala Ser Lys Phe Glu Leu 
225                 230                 235                 240 


Cys Gln Leu Leu Pro Leu Phe Leu Pro Pro Thr Thr Val Pro Pro Glu 
                245                 250                 255     


Cys Tyr Arg Asp Leu Gln Ala Gly Leu Ala Arg Ile Leu Gly Ser Lys 
            260                 265                 270         


Leu Ser Ser Trp Gln Arg Asn Pro Ala Leu Lys Leu Ala Ala Arg Leu 
        275                 280                 285             


Ala His Ala Cys Gly Ser Asp Trp Ile Pro Ala Gly Ser Ser Gly Ser 
    290                 295                 300                 


Lys Phe Leu Ala Leu Leu Val Asn Leu Ala Cys Val Glu Val Arg Leu 
305                 310                 315                 320 


Ala Leu Glu Glu Thr Gly Thr Glu Val Lys Glu Asp Val Val Thr Ala 
                325                 330                 335     


Cys Tyr Ala Leu Met Glu Leu Gly Ile Gln Glu Cys Thr Arg Cys Glu 
            340                 345                 350         


Gln Ser Leu Leu Lys Glu Pro Gln Lys Val Gln Leu Val Ser Val Met 
        355                 360                 365             


Lys Glu Ala Ile Gly Ala Val Ile His Tyr Leu Leu Gln Val Gly Ser 
    370                 375                 380                 


Glu Lys Gln Lys Glu Pro Phe Val Phe Ala Ser Val Arg Ile Leu Gly 
385                 390                 395                 400 


Ala Trp Leu Ala Glu Glu Thr Ser Ser Leu Arg Lys Glu Val Cys Gln 
                405                 410                 415     


Leu Leu Pro Phe Leu Val Arg Tyr Ala Lys Thr Leu Tyr Glu Glu Ala 
            420                 425                 430         


Glu Glu Ala Asn Asp Leu Ser Gln Gln Val Ala Asn Leu Ala Ile Ser 
        435                 440                 445             


Pro Thr Thr Pro Gly Pro Thr Trp Pro Gly Asp Ala Leu Arg Leu Leu 
    450                 455                 460                 


Leu Pro Gly Trp Cys His Leu Thr Val Glu Asp Gly Pro Arg Glu Ile 
465                 470                 475                 480 


Leu Ile Lys Glu Gly Ala Pro Ser Leu Leu Cys Lys Tyr Phe Leu Gln 
                485                 490                 495     


Gln Trp Glu Leu Thr Ser Pro Gly His Asp Thr Ser Val Leu Pro Asp 
            500                 505                 510         


Ser Val Glu Ile Gly Leu Gln Thr Cys Cys His Ile Phe Leu Asn Leu 
        515                 520                 525             


Val Val Thr Ala Pro Gly Leu Ile Lys Arg Asp Ala Cys Phe Thr Ser 
    530                 535                 540                 


Leu Met Asn Thr Leu Met Thr Ser Leu Pro Ala Leu Val Gln Gln Gln 
545                 550                 555                 560 


Gly Arg Leu Leu Leu Ala Ala Asn Val Ala Thr Leu Gly Leu Leu Met 
                565                 570                 575     


Ala Arg Leu Leu Ser Thr Ser Pro Ala Leu Gln Gly Thr Pro Ala Ser 
            580                 585                 590         


Arg Gly Phe Phe Ala Ala Ala Ile Leu Phe Leu Ser Gln Ser His Val 
        595                 600                 605             


Ala Arg Ala Thr Pro Gly Ser Asp Gln Ala Val Leu Ala Leu Ser Pro 
    610                 615                 620                 


Glu Tyr Glu Gly Ile Trp Ala Asp Leu Gln Glu Leu Trp Phe Leu Gly 
625                 630                 635                 640 


Met Gln Ala Phe Thr Gly Cys Val Pro Leu Leu Pro Trp Leu Ala Pro 
                645                 650                 655     


Ala Ala Leu Arg Ser Arg Trp Pro Gln Glu Leu Leu Gln Leu Leu Gly 
            660                 665                 670         


Ser Val Ser Pro Asn Ser Val Lys Pro Glu Met Val Ala Ala Tyr Gln 
        675                 680                 685             


Gly Val Leu Val Glu Leu Ala Arg Ala Asn Arg Leu Cys Arg Glu Ala 
    690                 695                 700                 


Met Arg Leu Gln Ala Gly Glu Glu Thr Ala Ser His Tyr Arg Met Ala 
705                 710                 715                 720 


Ala Leu Glu Gln Cys Leu Ser Glu Pro 
                725                 


<210>  131
<211>  2201
<212>  DNA
<213>  Homosapiens

<400>  131
gtgcccgtcc gtcctgcctc catggacccg cccgggaacg gccaccgctg aggaccccac     60

gcccactagg atcccggctg ggtcgcaccc agctaccgca ccgtgacctc cgcgggctgt    120

gccggctccc ggcgcctctg cccgcagcgc tcgccgtcgg gctagggctc cgccgccgcc    180

acgcctcgcg cccggcactc accgccccat gctggtgcac acctactccg ccatggagcg    240

ccccgacggg ctgggagcag ctgccggcgg ggcccgcctg tcgtctctgc cccaggcggc    300

ctacgggccg gcgcccccgc tctgccacac gccggccgcc acagctgccg ccgaattcca    360

gccgccctac ttcccgccgc cctacccgca gccaccgctg ccctacggtc aggcgcccga    420

cgccgccgca gcctttcccc acctggcagg ggacccatat ggcggcctgg cgcccctggc    480

gcagccgcag cctcctcagg ccgcctgggc cgcgccccgc gcagccgccc gcgcccacga    540

ggagcctccc ggcctgctgg caccgcccgc ccgcgccctg ggccttgacc cgcgccgtga    600

ctatgccact gccgtgcccc ggctcctgca cggcctggcc gacggcgcgc acggcctggc    660

agacgcacct ctcggccttc cggggctggc ggcggccccc ggtctggagg acctgcaggc    720

aatggacgag ccgggaatga gcctcctaga ccagtccgtg atcaagaaag tgcccatccc    780

ctccaaagcc agcagcctct cagccctctc cttggccaaa gacagcctgg tgggcggcat    840

cacaaatcct ggtgaggtct tctgctccgt gcccggccgg ctttcactgc tcagctcaac    900

gtccaagtac aaggtgacgg tgggggaggt gcagcggcga ctctcgcctc ccgagtgcct    960

caacgcctcc ctcctggggg gtgtcctccg cagggccaag tccaaaaatg ggggccggtg   1020

tttgcgggaa cggttagaga agattgggct caacctgcca gctggccgtc gcaaggccgc   1080

caatgtgacg ctgctgactt cgctagtgga aggagaggcc gtgcacctgg cccgagactt   1140

cggttacgtc tgtgagacgg agttcccagc caaggcagct gccgagtacc tgtgccgaca   1200

gcacgctgac ccgggggagc tgcacagccg caagagcatg ctgctggctg ccaagcagat   1260

ctgcaaggag tttgcagact tgatggctca ggaccgctca ccgctgggca acagccgccc   1320

agcactcatc ctggagcccg gagtacagag ctgcttgaca cactttagcc tcatcaccca   1380

tggcttcggt gggcctgcca tctgtgctgc cctcactgcc ttccagaact atttgctgga   1440

gtcactcaag gggctggaca agatgtttct aagcagtgtg ggcagtgggc atggtgaaac   1500

caaggcttcg gagaaggatg ccaagcatcg gaaataactg cttctcccac cccatcccta   1560

aggggctccc aggccctgaa atagggactt agctcttggg ggtgggcctg gaaggactga   1620

aaggtgggat tagagtcagg ccagaaagag aacattcatc cagagatccc agagttgggg   1680

atctggcttg gagtaaggga gggtggcctc tctgtggtgg tgtgttggta agttaagggc   1740

ccaggtattt gtctcatgtg tgcaattttc tgacctttga tggttgagaa gggtttggac   1800

agaaaattga catgaaaaga tctggctcat ggggcagagc cctttccatt agcgtggctg   1860

ggtggccgtg ggtgcttcta gaggccaaag cctttgtgtt tttcactggt ggcaggagga   1920

aaattgataa atcagaggtg ctactgagga gttggtgccc ctcattccag aatctcctac   1980

ccccagaaaa ggggtgctgg aaggaggccc cagtggactc tttgtaccct tcctactctc   2040

agagagaagt gggcaggagg ggtcctcaag gaacaaagaa gataaagcac aaatcgcaga   2100

acttgaatcc aggctgctgc tcatcatagt cctgttgctg tctgtcctat ttatttatgt   2160

atgttgtaat taaatttgaa attttaaaaa aaaaaaaaaa a                       2201


<210>  132
<211>  434
<212>  PRT
<213>  Homosapiens

<400>  132

Met Glu Arg Pro Asp Gly Leu Gly Ala Ala Ala Gly Gly Ala Arg Leu 
1               5                   10                  15      


Ser Ser Leu Pro Gln Ala Ala Tyr Gly Pro Ala Pro Pro Leu Cys His 
            20                  25                  30          


Thr Pro Ala Ala Thr Ala Ala Ala Glu Phe Gln Pro Pro Tyr Phe Pro 
        35                  40                  45              


Pro Pro Tyr Pro Gln Pro Pro Leu Pro Tyr Gly Gln Ala Pro Asp Ala 
    50                  55                  60                  


Ala Ala Ala Phe Pro His Leu Ala Gly Asp Pro Tyr Gly Gly Leu Ala 
65                  70                  75                  80  


Pro Leu Ala Gln Pro Gln Pro Pro Gln Ala Ala Trp Ala Ala Pro Arg 
                85                  90                  95      


Ala Ala Ala Arg Ala His Glu Glu Pro Pro Gly Leu Leu Ala Pro Pro 
            100                 105                 110         


Ala Arg Ala Leu Gly Leu Asp Pro Arg Arg Asp Tyr Ala Thr Ala Val 
        115                 120                 125             


Pro Arg Leu Leu His Gly Leu Ala Asp Gly Ala His Gly Leu Ala Asp 
    130                 135                 140                 


Ala Pro Leu Gly Leu Pro Gly Leu Ala Ala Ala Pro Gly Leu Glu Asp 
145                 150                 155                 160 


Leu Gln Ala Met Asp Glu Pro Gly Met Ser Leu Leu Asp Gln Ser Val 
                165                 170                 175     


Ile Lys Lys Val Pro Ile Pro Ser Lys Ala Ser Ser Leu Ser Ala Leu 
            180                 185                 190         


Ser Leu Ala Lys Asp Ser Leu Val Gly Gly Ile Thr Asn Pro Gly Glu 
        195                 200                 205             


Val Phe Cys Ser Val Pro Gly Arg Leu Ser Leu Leu Ser Ser Thr Ser 
    210                 215                 220                 


Lys Tyr Lys Val Thr Val Gly Glu Val Gln Arg Arg Leu Ser Pro Pro 
225                 230                 235                 240 


Glu Cys Leu Asn Ala Ser Leu Leu Gly Gly Val Leu Arg Arg Ala Lys 
                245                 250                 255     


Ser Lys Asn Gly Gly Arg Cys Leu Arg Glu Arg Leu Glu Lys Ile Gly 
            260                 265                 270         


Leu Asn Leu Pro Ala Gly Arg Arg Lys Ala Ala Asn Val Thr Leu Leu 
        275                 280                 285             


Thr Ser Leu Val Glu Gly Glu Ala Val His Leu Ala Arg Asp Phe Gly 
    290                 295                 300                 


Tyr Val Cys Glu Thr Glu Phe Pro Ala Lys Ala Ala Ala Glu Tyr Leu 
305                 310                 315                 320 


Cys Arg Gln His Ala Asp Pro Gly Glu Leu His Ser Arg Lys Ser Met 
                325                 330                 335     


Leu Leu Ala Ala Lys Gln Ile Cys Lys Glu Phe Ala Asp Leu Met Ala 
            340                 345                 350         


Gln Asp Arg Ser Pro Leu Gly Asn Ser Arg Pro Ala Leu Ile Leu Glu 
        355                 360                 365             


Pro Gly Val Gln Ser Cys Leu Thr His Phe Ser Leu Ile Thr His Gly 
    370                 375                 380                 


Phe Gly Gly Pro Ala Ile Cys Ala Ala Leu Thr Ala Phe Gln Asn Tyr 
385                 390                 395                 400 


Leu Leu Glu Ser Leu Lys Gly Leu Asp Lys Met Phe Leu Ser Ser Val 
                405                 410                 415     


Gly Ser Gly His Gly Glu Thr Lys Ala Ser Glu Lys Asp Ala Lys His 
            420                 425                 430         


Arg Lys 
        


<210>  133
<211>  850
<212>  DNA
<213>  Homosapiens

<400>  133
ctgcaggcgt cgcgccaatc ttcgctctga ggtgctgtct caccggtgag acctggaagc     60

gggcgagtct cgtgctgtgt cggacctgca gcccctggcc ttccgccacc atggagtacc    120

tcatcggtat ccaaggcccc gactatgttc ttgtcgcctc cgaccgggtg gccgccagca    180

atattgtcca gatgaaggac gatcatgaca agatgtttaa gatgagtgaa aagatattac    240

tcctgtgtgt tggagaggct ggagacactg tacagtttgc agaatatatt cagaaaaacg    300

tgcaacttta taagatgcga aatggatatg aattgtctcc cacggcagca gctaacttca    360

cacgccgaaa cctggctgac tgtcttcgga gtcggacccc atatcatgtg aacctcctcc    420

tggctggcta tgatgagcat gaagggccag cgctgtatta catggactac ctggcagcct    480

tggccaaggc cccttttgca gcccacggct atggtgcctt cctgactctc agtatcctcg    540

accgatacta cacaccgact atctcacgtg agagggcagt ggaactcctt aggaaatgtc    600

tggaggagct ccagaaacgc ttcatcctga atctgccaac cttcagtgtt cgaatcattg    660

acaaaaatgg catccatgac ctggataaca tttccttccc caaacagggc tcctaacatc    720

atgtcctccc tcccacttgc cagggaactt ttttttgatg ggctccttta tttttttcta    780

ctcttttcag gcgcactctt gataaatggt taattcagaa taaaggtgac tatggatata    840

attgaaaaaa                                                           850


<210>  134
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  134

Met Glu Tyr Leu Ile Gly Ile Gln Gly Pro Asp Tyr Val Leu Val Ala 
1               5                   10                  15      


Ser Asp Arg Val Ala Ala Ser Asn Ile Val Gln Met Lys Asp Asp His 
            20                  25                  30          


Asp Lys Met Phe Lys Met Ser Glu Lys Ile Leu Leu Leu Cys Val Gly 
        35                  40                  45              


Glu Ala Gly Asp Thr Val Gln Phe Ala Glu Tyr Ile Gln Lys Asn Val 
    50                  55                  60                  


Gln Leu Tyr Lys Met Arg Asn Gly Tyr Glu Leu Ser Pro Thr Ala Ala 
65                  70                  75                  80  


Ala Asn Phe Thr Arg Arg Asn Leu Ala Asp Cys Leu Arg Ser Arg Thr 
                85                  90                  95      


Pro Tyr His Val Asn Leu Leu Leu Ala Gly Tyr Asp Glu His Glu Gly 
            100                 105                 110         


Pro Ala Leu Tyr Tyr Met Asp Tyr Leu Ala Ala Leu Ala Lys Ala Pro 
        115                 120                 125             


Phe Ala Ala His Gly Tyr Gly Ala Phe Leu Thr Leu Ser Ile Leu Asp 
    130                 135                 140                 


Arg Tyr Tyr Thr Pro Thr Ile Ser Arg Glu Arg Ala Val Glu Leu Leu 
145                 150                 155                 160 


Arg Lys Cys Leu Glu Glu Leu Gln Lys Arg Phe Ile Leu Asn Leu Pro 
                165                 170                 175     


Thr Phe Ser Val Arg Ile Ile Asp Lys Asn Gly Ile His Asp Leu Asp 
            180                 185                 190         


Asn Ile Ser Phe Pro Lys Gln Gly Ser 
        195                 200     


<210>  135
<211>  2934
<212>  DNA
<213>  Homosapiens

<400>  135
aggacgcaca gagccccgcg gctaccgcct taggggttgt cccggcggtg gggaagccat     60

tgaggagttt aacgccggaa ggtggtgact aatcagattt cacttgaaaa tggcacggtg    120

tctgcagcga ggctaactga tgggaagggc ccagcgaatg ccaataggag agagcaccgg    180

acctggaagg cctgggtcaa cgcggccccg cgcgggggcg aagcggttcc ggcgcagggg    240

cctggcgcgg ggctccgcgg aaaaccgaac cggcccacgt gggaccggtc gctccgccct    300

gctgcgcaga cgccgcctga ctccgcagtc cgggactggg gctgggcgcg ctgcccggga    360

gccccgcacc cacgcctgga ccgcggagac gcccaggccg aggaaccccc agcccaggga    420

ctagacacca ccagggccgg gcggagccag agccagacgc gccggagcgg gcgcctctac    480

gccgctagat gttcgccatc cagccagggc tagctgaggg gggccaattc ctgggggacc    540

cacctcctgg attatgtcag cccgagctcc aaccagacag caactccaac ttcatggcaa    600

gtgccaagga tgctaacgag aattggcatg ggatgccagg cagagtggaa cctatcctga    660

ggaggagctc ctctgagtca ccctctgaca accaagcctt ccaggcccct ggatcccctg    720

aggaaggggt gcgcagcccc ccagaggggg cagagattcc cggggctgag cctgagaaga    780

tgggtggtgc tggcacagtc tgctcccctc tggaggacaa cggctatgcc agcagttccc    840

tgagcattga cagccgtagc agcagtcctg agcctgcctg tgggaccccg cgaggccctg    900

gccctcccga tccccttctg ccctcagtgg cccaggctgt gcagcactta caagtccagg    960

agcgctacaa agagcaggag aaggaaaagc accacgtgca cttggtgatg taccgtcgcc   1020

tggcactgct ccagtggatc cggggcctgc agcatcagtt gattgaccag caggcccgac   1080

tgcaggagag cttcgacacc atcctagaca accggaagga gcttattcgc tgtctccagc   1140

agagggcagc accatccagg ccccaggacc aggcctaagg gtgtgcctcc acaagtgtgc   1200

aagggtatat gtatatattt gcaggcatgt gtgaggcgca ctagtaagta cataatttgc   1260

tggcatgatt gcaggtaggc atgagtgtgt atgtgctaac atgtaggctg gtgtgtgtag   1320

gcatgtgtga ataagcatgt ataaatgagc ttaagtgtgc tgtgtgcaca tgtgtacaca   1380

cagctaattt atctgcagac ctatatgtga gcatgtaaga gtgaacatat gtgtgtgtgt   1440

gtagtatgta agaatgagga actcggtatg tgcatgtgta gacaggtacc cagcagtgtg   1500

tgtatatgcg catgagtgag gatgtatagg cagaagatgt gtgtgtctat gagtgagttt   1560

gagtgtgcag gcttgtatta ggtgtatgtg aggaagccct tgtgtgtgca ggggtgcaca   1620

tgtttggcca caggcatggg aggtgtatgt taggagcatg tgtgtttgta ggcagactca   1680

tgagcaggtg tgtgcaaata catatccagc tgcactgtgg gtgtccaccc acaccttgtg   1740

ttcctcatgg cctaccccag cctttcttct ccactgggtc ccactgttcc ctggagacag   1800

agggctagca tgctgtcatt tatctgaagg ttgtggctga cccattctcc tgggatttcc   1860

caggccacct ctcctttccc tttccctcac ttaacccaga cttgctcagc tgaggctatt   1920

gtccctgatg ttggctttac ttgtaggagg tttagtggct gctctggcct gccatggaat   1980

tttggctgca attttggcag tgtgtggaga actggtatca ggaaagggaa ccaggagtag   2040

tgatgaagat gatggtgggg atggggacag aggacatagg ggactgtccc tcttgaactc   2100

tgcctttggg cacatgggag atggggacag gaaagatgat aacagtggaa ccctgtgaag   2160

aataggagaa tgggaattct aaaataccag ttcccaaaca aaccatctct ccattggaaa   2220

aggagctgtt gcaaaccgtg ttcatttaag cttctgatga aaagcaatgt atgtttataa   2280

gcttgcaagt aacagacaag atgttccaag gccgatgagg aaaatatcgc ttccctgtct   2340

ctgcctctac cttgctgtgc ctctctggct ttagcagcat tggatgttga attggtttgg   2400

ttcatttctc tgaagtcgga ctgtcaggag gagccagagg ttggctttct gggatgtgaa   2460

ggggacagtg tcagcctaag cctctggaga tgcttaggat gctgaatttt aaccccttct   2520

ttcactgcat ggcccttcaa acagggattg gcaggctccg cgagttacag agtgggtgag   2580

tcttggagag aaccaacgac taaggtagct tagctctctg ctttgttctt gggagccaag   2640

agaatgcaag atcctggtgg gtgagcagtg gtatgaagag gggacactgg tgggtgaaca   2700

gtggcatgga agtcactgat gcagcctctg gccctcagtc tccctatcgg caaagtgggg   2760

ggctcttcct atctctaaag agtttcatcc ctgacaggtg gatgggtgaa agatccagag   2820

agtgggggtg aggggtgggc cctgaagact ttttgtctgt agctcttgca tattgagtgt   2880

ataaacccgg cttctggacc aacccaagat gaataaactg gggcagaaaa ttac         2934


<210>  136
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  136

Met Phe Ala Ile Gln Pro Gly Leu Ala Glu Gly Gly Gln Phe Leu Gly 
1               5                   10                  15      


Asp Pro Pro Pro Gly Leu Cys Gln Pro Glu Leu Gln Pro Asp Ser Asn 
            20                  25                  30          


Ser Asn Phe Met Ala Ser Ala Lys Asp Ala Asn Glu Asn Trp His Gly 
        35                  40                  45              


Met Pro Gly Arg Val Glu Pro Ile Leu Arg Arg Ser Ser Ser Glu Ser 
    50                  55                  60                  


Pro Ser Asp Asn Gln Ala Phe Gln Ala Pro Gly Ser Pro Glu Glu Gly 
65                  70                  75                  80  


Val Arg Ser Pro Pro Glu Gly Ala Glu Ile Pro Gly Ala Glu Pro Glu 
                85                  90                  95      


Lys Met Gly Gly Ala Gly Thr Val Cys Ser Pro Leu Glu Asp Asn Gly 
            100                 105                 110         


Tyr Ala Ser Ser Ser Leu Ser Ile Asp Ser Arg Ser Ser Ser Pro Glu 
        115                 120                 125             


Pro Ala Cys Gly Thr Pro Arg Gly Pro Gly Pro Pro Asp Pro Leu Leu 
    130                 135                 140                 


Pro Ser Val Ala Gln Ala Val Gln His Leu Gln Val Gln Glu Arg Tyr 
145                 150                 155                 160 


Lys Glu Gln Glu Lys Glu Lys His His Val His Leu Val Met Tyr Arg 
                165                 170                 175     


Arg Leu Ala Leu Leu Gln Trp Ile Arg Gly Leu Gln His Gln Leu Ile 
            180                 185                 190         


Asp Gln Gln Ala Arg Leu Gln Glu Ser Phe Asp Thr Ile Leu Asp Asn 
        195                 200                 205             


Arg Lys Glu Leu Ile Arg Cys Leu Gln Gln Arg Ala Ala Pro Ser Arg 
    210                 215                 220                 


Pro Gln Asp Gln Ala 
225                 


<210>  137
<211>  4379
<212>  DNA
<213>  Homosapiens

<400>  137
gacggcggga gccgctgctc tccggctgag ggaatcagag acagctccgt ccctagtgga     60

gcgcagggga ggcagaagtc atgacaggcg aggtgggttc tgaggttcac ctagaaatca    120

atgacccaaa cgtcatttca caagaggaag cagatagtcc ttcagatagt ggacagggca    180

gctatgaaac aattggaccc ttgagtgaag gagattcaga tgaagagata tttgtaagta    240

agaagttgaa aaacaggaag gttctacaag acagtgattc cgaaacagag gacacaaatg    300

cctctccaga gaaaactacc tatgacagtg ccgaggagga aaataaagag aatttatatg    360

ctgggaaaaa tacaaaaatc aaaaggattt acaaaactgt ggcagacagt gatgaaagtt    420

acatggaaaa gtctttgtat caggaaaatc ttgaagcgca agtgaaacct tgcttagagc    480

tgagtcttca gtctggaaac tctacagact ttaccactga cagaaagagt tccaaaaagc    540

acatacatga taaagaagga actgcaggaa aagcaaaagt aaaatcaaaa agaagacttg    600

agaaagagga gagaaaaatg gaaaaaatta gacagctaaa aaagaaggaa acaaaaaacc    660

aggaagatga tgtagaacag ccatttaatg acagtggctg tcttcttgtg gataaagacc    720

tttttgaaac tgggttggag gatgaaaata actctccatt ggaagatgaa gagtcattag    780

aatcaataag agcagctgta aaaaacaaag taaaaaagca caagaaaaaa gaaccatctt    840

tggagagtgg ggtccattca tttgaggaag gaagtgagtt atcaaaagga accacgagga    900

aggaaagaaa ggcagccaga ttaagtaaag aagcattaaa acaactgcat agtgagactc    960

agcgccttat tcgagagtct gcactgaacc ttccatatca tatgcctgag aataaaacca   1020

ttcatgattt cttcaaacgt aaaccccggc ccacttgcca cggaaatgcc atggcactat   1080

tgaagtcatc taaatatcag tcaagccatc acaaagaaat catagacact gcaaatacta   1140

ctgaaatgaa cagtgatcac catagtaaag gttctgagca gacaacaggt gcagaaaatg   1200

aagtggaaac taatgcactc cctgtagttt caaaggaaac ccagatcatt actggatcag   1260

atgagtcttg caggaaggat ttggtaaaaa atgaagagct agaaattcag gagaaacaga   1320

agcagagtga cattagacct tcacctgggg acagctcagt gttgcaacag gaatccaact   1380

tcctcgggaa caatcacagt gaggaatgtc aggttggagg gcttgtagca tttgaacctc   1440

atgccctgga gggtgaaggc ccccaaaatc cagaagaaac agatgagaaa gtggaagagc   1500

ctgagcagca aaataaatca tcagcagttg ggccacctga aaaagtgaga cggtttactc   1560

tggatagact taagcaactg ggagtagatg tttccattaa accacggcta ggtgctgatg   1620

aagattcctt tgtgatactt gaacctgaaa ccaacagaga actggaagcc ttgaagcagc   1680

gtttctggaa gcatgctaat ccagcagcca aacccagggc tggtcagaca gtgaatgtga   1740

acgtcatagt gaaagacatg ggcactgatg gaaaggaaga gctaaaagca gatgtggtac   1800

ctgtgacttt agcacctaag aagttggatg gagcaagcca cacaaaacca ggtgaaaagc   1860

ttcaggtgtt aaaagctaaa ctgcaagaag caatgaaact ccgaaggttt gaggagcgcc   1920

agaagcgcca agcactgttt aaattagata atgaagatgg gtttgaggaa gaggaggagg   1980

aagaggaaga aatgacagat gagtctgagg aagatggaga agagaaggta gagaaagaag   2040

agaaagagga agaactagag gaagaggagg agaaagaaga ggaggaggaa gaagaaggaa   2100

atcaggagac tgcagaattc cttcttagta gtgaagaaat agaaacaaaa gatgaaaaag   2160

aaatggataa agaaaataat gatggcagta gtgaaattgg caaggcagtt ggcttcctct   2220

ctgttcccaa gtctctctca tcagattcta ctttacttct gtttaaggac agctcttcca   2280

agatgggtta ctttcctact gaagaaaaat cagaaacaga tgaaaactca ggcaagcagc   2340

ctagcaaact ggatgaggat gattcatgtt cattgctaac aaaggagagc agccacaata   2400

gcagctttga gctgattggc tccacgattc catcctatca gccttgcaac agacaaacag   2460

gccgtgggac cagttttttc cctacagcag gaggattcag atctccttcc cctgggctat   2520

ttcgagccag tttggtcagc tcagcttcta agagttcagg gaaactgtct gagccttcac   2580

ttcccataga ggattcccag gatctgtata acgcctcccc agagcctaag acacttttcc   2640

taggagcagg agacttccag ttctgtttag aagatgacac tcagagccaa ctgttggatg   2700

cagatgggtt cttaaatgtt agaaaccaca ggaatcagta ccaagctttg aagcctcgat   2760

tgccattggc cagtatggat gagaatgcca tggatgccaa catggatgag ctgttggatt   2820

tgtgtactgg aaagttcaca tctcaggctg aaaaacatct acccaggaag agtgacaaga   2880

aagagaacat ggaggaactt ctgaaccttt gttcaggaaa attcacttct caggatgcct   2940

ccactccagc ctcatcagag ttaaataaac aggagaagga gagcagcatg ggtgatccaa   3000

tggaagaagc acttgctctt tgctcaggct cttttcccac agacaaggaa gaggaagacg   3060

aggaggagga atttggagac tttcggcttg tttcaaatga taatgagttt gatagtgatg   3120

aggatgaaca cagtgactct ggtaatgatc tggcactgga agaccatgaa gatgatgatg   3180

aagaagaact cctgaagcga tctgagaagt tgaaaaggca aatgaggttg aggaaatacc   3240

tggaggatga ggcagaggtg tcaggaagtg atgtgggaag cgaagatgag tatgatgggg   3300

aagaaattga tgaatatgaa gaggacgtaa ttgatgaagt acttccttct gatgaggaac   3360

tgcagagtca aatcaagaaa atacacatga aaactatgtt ggatgatgat aagcgacagc   3420

tacgtttata ccaagagagg taccttgctg atggggatct gcacagcgat ggtcctgggc   3480

gaatgaggaa gtttcgatgg aaaaacatag atgatgcttc ccagatggac ttgttccaca   3540

gagactctga tgatgatcag actgaagaac agcttgatga gtcagaagcc aggtggagga   3600

aggagcgaat tgaacgagag cagtggcttc gggacatggc acagcagggg aaaattacag   3660

ctgaagaaga agaagaaatt ggggaggaca gtcagtttat gatactggcc aagaaagtta   3720

cagccaaagc actgcagaag aatgccagtc gccctatggt tattcaggaa tcaaagtctt   3780

tgctcagaaa tccttttgaa gccatcagac caggaagtgc tcaacaggtg aagacaggct   3840

cactgctaaa ccagcccaaa gctgtgcttc agaaactggc tgctctctct gaccataacc   3900

ccagtgctcc tcgaaattca agaaactttg tctttcatac actttctcct gtcaaggctg   3960

aggcggcaaa ggaatcgtct aagtctcagg taaagaaaag gggtccatct ttcatgactt   4020

ctccttcacc taagcacctc aaaacagatg atagcacttc aggattgacg cgaagcatct   4080

tcaaatattt ggagagctaa caccatcaaa ggtgccaaaa tctacattga gactgctttg   4140

agaagtttct agcactgaaa gttggaattg acactccagc caatgatcct tccttctttc   4200

ataatcaatg caataagatt gcagacagaa attccagtga tttctactgc acagctctgg   4260

acatctcttt tcctagtatt attccctgaa ttggccactg atttcaattc tgcagtattt   4320

acaacatcaa caactcatgg aatacttggg tgaggtttcc tttttttttt tttttttaa    4379


<210>  138
<211>  1339
<212>  PRT
<213>  Homosapiens

<400>  138

Met Thr Gly Glu Val Gly Ser Glu Val His Leu Glu Ile Asn Asp Pro 
1               5                   10                  15      


Asn Val Ile Ser Gln Glu Glu Ala Asp Ser Pro Ser Asp Ser Gly Gln 
            20                  25                  30          


Gly Ser Tyr Glu Thr Ile Gly Pro Leu Ser Glu Gly Asp Ser Asp Glu 
        35                  40                  45              


Glu Ile Phe Val Ser Lys Lys Leu Lys Asn Arg Lys Val Leu Gln Asp 
    50                  55                  60                  


Ser Asp Ser Glu Thr Glu Asp Thr Asn Ala Ser Pro Glu Lys Thr Thr 
65                  70                  75                  80  


Tyr Asp Ser Ala Glu Glu Glu Asn Lys Glu Asn Leu Tyr Ala Gly Lys 
                85                  90                  95      


Asn Thr Lys Ile Lys Arg Ile Tyr Lys Thr Val Ala Asp Ser Asp Glu 
            100                 105                 110         


Ser Tyr Met Glu Lys Ser Leu Tyr Gln Glu Asn Leu Glu Ala Gln Val 
        115                 120                 125             


Lys Pro Cys Leu Glu Leu Ser Leu Gln Ser Gly Asn Ser Thr Asp Phe 
    130                 135                 140                 


Thr Thr Asp Arg Lys Ser Ser Lys Lys His Ile His Asp Lys Glu Gly 
145                 150                 155                 160 


Thr Ala Gly Lys Ala Lys Val Lys Ser Lys Arg Arg Leu Glu Lys Glu 
                165                 170                 175     


Glu Arg Lys Met Glu Lys Ile Arg Gln Leu Lys Lys Lys Glu Thr Lys 
            180                 185                 190         


Asn Gln Glu Asp Asp Val Glu Gln Pro Phe Asn Asp Ser Gly Cys Leu 
        195                 200                 205             


Leu Val Asp Lys Asp Leu Phe Glu Thr Gly Leu Glu Asp Glu Asn Asn 
    210                 215                 220                 


Ser Pro Leu Glu Asp Glu Glu Ser Leu Glu Ser Ile Arg Ala Ala Val 
225                 230                 235                 240 


Lys Asn Lys Val Lys Lys His Lys Lys Lys Glu Pro Ser Leu Glu Ser 
                245                 250                 255     


Gly Val His Ser Phe Glu Glu Gly Ser Glu Leu Ser Lys Gly Thr Thr 
            260                 265                 270         


Arg Lys Glu Arg Lys Ala Ala Arg Leu Ser Lys Glu Ala Leu Lys Gln 
        275                 280                 285             


Leu His Ser Glu Thr Gln Arg Leu Ile Arg Glu Ser Ala Leu Asn Leu 
    290                 295                 300                 


Pro Tyr His Met Pro Glu Asn Lys Thr Ile His Asp Phe Phe Lys Arg 
305                 310                 315                 320 


Lys Pro Arg Pro Thr Cys His Gly Asn Ala Met Ala Leu Leu Lys Ser 
                325                 330                 335     


Ser Lys Tyr Gln Ser Ser His His Lys Glu Ile Ile Asp Thr Ala Asn 
            340                 345                 350         


Thr Thr Glu Met Asn Ser Asp His His Ser Lys Gly Ser Glu Gln Thr 
        355                 360                 365             


Thr Gly Ala Glu Asn Glu Val Glu Thr Asn Ala Leu Pro Val Val Ser 
    370                 375                 380                 


Lys Glu Thr Gln Ile Ile Thr Gly Ser Asp Glu Ser Cys Arg Lys Asp 
385                 390                 395                 400 


Leu Val Lys Asn Glu Glu Leu Glu Ile Gln Glu Lys Gln Lys Gln Ser 
                405                 410                 415     


Asp Ile Arg Pro Ser Pro Gly Asp Ser Ser Val Leu Gln Gln Glu Ser 
            420                 425                 430         


Asn Phe Leu Gly Asn Asn His Ser Glu Glu Cys Gln Val Gly Gly Leu 
        435                 440                 445             


Val Ala Phe Glu Pro His Ala Leu Glu Gly Glu Gly Pro Gln Asn Pro 
    450                 455                 460                 


Glu Glu Thr Asp Glu Lys Val Glu Glu Pro Glu Gln Gln Asn Lys Ser 
465                 470                 475                 480 


Ser Ala Val Gly Pro Pro Glu Lys Val Arg Arg Phe Thr Leu Asp Arg 
                485                 490                 495     


Leu Lys Gln Leu Gly Val Asp Val Ser Ile Lys Pro Arg Leu Gly Ala 
            500                 505                 510         


Asp Glu Asp Ser Phe Val Ile Leu Glu Pro Glu Thr Asn Arg Glu Leu 
        515                 520                 525             


Glu Ala Leu Lys Gln Arg Phe Trp Lys His Ala Asn Pro Ala Ala Lys 
    530                 535                 540                 


Pro Arg Ala Gly Gln Thr Val Asn Val Asn Val Ile Val Lys Asp Met 
545                 550                 555                 560 


Gly Thr Asp Gly Lys Glu Glu Leu Lys Ala Asp Val Val Pro Val Thr 
                565                 570                 575     


Leu Ala Pro Lys Lys Leu Asp Gly Ala Ser His Thr Lys Pro Gly Glu 
            580                 585                 590         


Lys Leu Gln Val Leu Lys Ala Lys Leu Gln Glu Ala Met Lys Leu Arg 
        595                 600                 605             


Arg Phe Glu Glu Arg Gln Lys Arg Gln Ala Leu Phe Lys Leu Asp Asn 
    610                 615                 620                 


Glu Asp Gly Phe Glu Glu Glu Glu Glu Glu Glu Glu Glu Met Thr Asp 
625                 630                 635                 640 


Glu Ser Glu Glu Asp Gly Glu Glu Lys Val Glu Lys Glu Glu Lys Glu 
                645                 650                 655     


Glu Glu Leu Glu Glu Glu Glu Glu Lys Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gly Asn Gln Glu Thr Ala Glu Phe Leu Leu Ser Ser Glu Glu Ile Glu 
        675                 680                 685             


Thr Lys Asp Glu Lys Glu Met Asp Lys Glu Asn Asn Asp Gly Ser Ser 
    690                 695                 700                 


Glu Ile Gly Lys Ala Val Gly Phe Leu Ser Val Pro Lys Ser Leu Ser 
705                 710                 715                 720 


Ser Asp Ser Thr Leu Leu Leu Phe Lys Asp Ser Ser Ser Lys Met Gly 
                725                 730                 735     


Tyr Phe Pro Thr Glu Glu Lys Ser Glu Thr Asp Glu Asn Ser Gly Lys 
            740                 745                 750         


Gln Pro Ser Lys Leu Asp Glu Asp Asp Ser Cys Ser Leu Leu Thr Lys 
        755                 760                 765             


Glu Ser Ser His Asn Ser Ser Phe Glu Leu Ile Gly Ser Thr Ile Pro 
    770                 775                 780                 


Ser Tyr Gln Pro Cys Asn Arg Gln Thr Gly Arg Gly Thr Ser Phe Phe 
785                 790                 795                 800 


Pro Thr Ala Gly Gly Phe Arg Ser Pro Ser Pro Gly Leu Phe Arg Ala 
                805                 810                 815     


Ser Leu Val Ser Ser Ala Ser Lys Ser Ser Gly Lys Leu Ser Glu Pro 
            820                 825                 830         


Ser Leu Pro Ile Glu Asp Ser Gln Asp Leu Tyr Asn Ala Ser Pro Glu 
        835                 840                 845             


Pro Lys Thr Leu Phe Leu Gly Ala Gly Asp Phe Gln Phe Cys Leu Glu 
    850                 855                 860                 


Asp Asp Thr Gln Ser Gln Leu Leu Asp Ala Asp Gly Phe Leu Asn Val 
865                 870                 875                 880 


Arg Asn His Arg Asn Gln Tyr Gln Ala Leu Lys Pro Arg Leu Pro Leu 
                885                 890                 895     


Ala Ser Met Asp Glu Asn Ala Met Asp Ala Asn Met Asp Glu Leu Leu 
            900                 905                 910         


Asp Leu Cys Thr Gly Lys Phe Thr Ser Gln Ala Glu Lys His Leu Pro 
        915                 920                 925             


Arg Lys Ser Asp Lys Lys Glu Asn Met Glu Glu Leu Leu Asn Leu Cys 
    930                 935                 940                 


Ser Gly Lys Phe Thr Ser Gln Asp Ala Ser Thr Pro Ala Ser Ser Glu 
945                 950                 955                 960 


Leu Asn Lys Gln Glu Lys Glu Ser Ser Met Gly Asp Pro Met Glu Glu 
                965                 970                 975     


Ala Leu Ala Leu Cys Ser Gly Ser Phe Pro Thr Asp Lys Glu Glu Glu 
            980                 985                 990         


Asp Glu Glu Glu Glu Phe Gly Asp  Phe Arg Leu Val Ser  Asn Asp Asn 
        995                 1000                 1005             


Glu Phe  Asp Ser Asp Glu Asp  Glu His Ser Asp Ser  Gly Asn Asp 
    1010                 1015                 1020             


Leu Ala  Leu Glu Asp His Glu  Asp Asp Asp Glu Glu  Glu Leu Leu 
    1025                 1030                 1035             


Lys Arg  Ser Glu Lys Leu Lys  Arg Gln Met Arg Leu  Arg Lys Tyr 
    1040                 1045                 1050             


Leu Glu  Asp Glu Ala Glu Val  Ser Gly Ser Asp Val  Gly Ser Glu 
    1055                 1060                 1065             


Asp Glu  Tyr Asp Gly Glu Glu  Ile Asp Glu Tyr Glu  Glu Asp Val 
    1070                 1075                 1080             


Ile Asp  Glu Val Leu Pro Ser  Asp Glu Glu Leu Gln  Ser Gln Ile 
    1085                 1090                 1095             


Lys Lys  Ile His Met Lys Thr  Met Leu Asp Asp Asp  Lys Arg Gln 
    1100                 1105                 1110             


Leu Arg  Leu Tyr Gln Glu Arg  Tyr Leu Ala Asp Gly  Asp Leu His 
    1115                 1120                 1125             


Ser Asp  Gly Pro Gly Arg Met  Arg Lys Phe Arg Trp  Lys Asn Ile 
    1130                 1135                 1140             


Asp Asp  Ala Ser Gln Met Asp  Leu Phe His Arg Asp  Ser Asp Asp 
    1145                 1150                 1155             


Asp Gln  Thr Glu Glu Gln Leu  Asp Glu Ser Glu Ala  Arg Trp Arg 
    1160                 1165                 1170             


Lys Glu  Arg Ile Glu Arg Glu  Gln Trp Leu Arg Asp  Met Ala Gln 
    1175                 1180                 1185             


Gln Gly  Lys Ile Thr Ala Glu  Glu Glu Glu Glu Ile  Gly Glu Asp 
    1190                 1195                 1200             


Ser Gln  Phe Met Ile Leu Ala  Lys Lys Val Thr Ala  Lys Ala Leu 
    1205                 1210                 1215             


Gln Lys  Asn Ala Ser Arg Pro  Met Val Ile Gln Glu  Ser Lys Ser 
    1220                 1225                 1230             


Leu Leu  Arg Asn Pro Phe Glu  Ala Ile Arg Pro Gly  Ser Ala Gln 
    1235                 1240                 1245             


Gln Val  Lys Thr Gly Ser Leu  Leu Asn Gln Pro Lys  Ala Val Leu 
    1250                 1255                 1260             


Gln Lys  Leu Ala Ala Leu Ser  Asp His Asn Pro Ser  Ala Pro Arg 
    1265                 1270                 1275             


Asn Ser  Arg Asn Phe Val Phe  His Thr Leu Ser Pro  Val Lys Ala 
    1280                 1285                 1290             


Glu Ala  Ala Lys Glu Ser Ser  Lys Ser Gln Val Lys  Lys Arg Gly 
    1295                 1300                 1305             


Pro Ser  Phe Met Thr Ser Pro  Ser Pro Lys His Leu  Lys Thr Asp 
    1310                 1315                 1320             


Asp Ser  Thr Ser Gly Leu Thr  Arg Ser Ile Phe Lys  Tyr Leu Glu 
    1325                 1330                 1335             


Ser 
    


<210>  139
<211>  4758
<212>  DNA
<213>  Homosapiens

<400>  139
gagccggagc cgggtccctg tccccgggcc gggcgccgcc gccgccccct gcccagcgcc     60

cgcgtctccg cggcgccacc ccagcgccaa tattccggag atcaagcgtt acgcggcggc    120

ggcggcggcg gcggcggggc ccggagcggg aggcgccggg gaccggggcg aggcggcccc    180

cgccgccgcc atggaggcgc tgggacccgg acctccggct agcctgtttc agccacctcg    240

tcgtcctggc cttggaactg ttggaaaacc aattcgactg ttagccaatc attttcaggt    300

tcagattcct aaaatagatg tgtatcacta tgatgtggat attaagcctg aaaaacggcc    360

tcgtagagtc aacagggagg tagtagatac aatggtgcgg cacttcaaga tgcaaatatt    420

tggtgatcgg cagcctgggt atgatggcaa aagaaacatg tacacagcac atccactacc    480

aattggacgg gatagggttg atatggaggt gactcttcca ggcgagggta aagaccaaac    540

atttaaagtg tctgttcagt gggtgtcagt tgtgagcctt cagttgcttt tagaagcttt    600

ggctgggcac ttgaatgaag tcccagatga ctcagtacaa gcacttgatg ttatcacaag    660

acaccttccc tccatgaggt acaccccagt gggccgttcc tttttctcac ccccggaagg    720

ttactaccac cctctgggag ggggcaggga ggtctggttt ggttttcatc agtctgtgag    780

acctgccatg tggaatatga tgctcaacat tgatgtatct gcaactgctt tctaccgggc    840

tcagcctatc attgagttca tgtgtgaggt tttagacatt cagaacatca atgaacagac    900

caaacctcta acagactccc agcgtgtcaa atttaccaaa gaaatcagag gtctcaaagt    960

tgaggtgacc cactgtggac agatgaaacg aaaataccga gtttgtaatg tgactagacg   1020

gccagccagt catcaaactt ttcctttgca gctagaaaac ggtcaagcta tggaatgtac   1080

agtagctcaa tattttaagc aaaagtatag tctgcaactg aaataccccc atcttccctg   1140

tctccaagtg ggacaagaac aaaagcatac atacttgcca ctcgaggtct gtaatatagt   1200

ggcaggacag cgatgtatca agaagctcac agacaatcag acttccacaa tgatcaaagc   1260

tacagcaaga tctgctcctg acagacagga agagatcagt agactggtga agagcaacag   1320

tatggtgggt ggacctgatc cataccttaa agaatttggt attgttgtcc acaatgaaat   1380

gacagagctc acaggcaggg tacttccagc accaatgctg caatatggag gccggaataa   1440

aacagtagcc acacccaacc agggtgtctg ggacatgcga ggaaagcagt tttatgctgg   1500

cattgaaatt aaagtttggg cagttgcttg ttttgcacct cagaaacaat gtagggaaga   1560

tttactaaag agtttcactg accagctgcg taaaatctct aaggatgcag gaatgcccat   1620

ccagggtcag ccatgtttct gcaagtatgc acaaggtgca gacagtgtgg agcctatgtt   1680

taaacatctg aaaatgactt atgtgggcct acagctaata gtggttatcc tgcctggaaa   1740

gacaccagta tatgcggagg tgaaacgtgt tggagatacc cttctaggta tggccacaca   1800

gtgtgtccag gtaaaaaatg tagtgaagac ctcacctcaa accctttcca atctttgcct   1860

gaagataaat gcaaaacttg gaggaattaa caatgtgctt gtgcctcatc aaaggccctc   1920

ggtgttccag cagcctgtca tcttcctggg agcggatgtc acacaccccc cagcagggga   1980

tgggaagaaa ccttccattg ctgctgtggt tggcagtatg gatggccacc ccagccggta   2040

ctgtgccacc gttcgggtgc agacttcccg gcaggagatc tcccaagagc tcctctacag   2100

tcaagaggtc atccaggacc tgactaacat ggttcgagag ctgctgattc agttctacaa   2160

atccacacgc ttcaaaccca ctcggatcat ctattaccgt ggaggggtat ctgagggaca   2220

aatgaaacag gtagcttggc cagaactaat agcaattcga aaggcatgta ttagcttgga   2280

agaagattac cggccaggaa taacttatat tgtggtgcaa aaaagacatc acacacgact   2340

cttctgtgca gataaaacag aaagggtagg gaaaagtggc aatgtaccag caggcactac   2400

agtggatagt accatcacac atccatctga gtttgacttt tacctctgta gtcatgcagg   2460

aattcaggga accagccgtc cctcacatta ccaggtcttg tgggatgaca actgcttcac   2520

tgcagatgaa ctccagctac tgacttacca gctgtgtcac acctatgtga ggtgcactcg   2580

ctcagtctct attccagccc ctgcatatta tgcccggctt gtagcattta gggcaaggta   2640

tcatctggtg gataaagatc atgacagtgc ggaaggcagt catgtgtcag gacagagcaa   2700

cggccgggat cctcaggcct tggctaaggc tgtgcaaatc caccatgata cccagcacac   2760

gatgtatttt gcctgagagt ctcagaaaaa gaactcaacc aatttggcac cccatgcagc   2820

ctcaaaatgt ttcaaatgcc taccgcctct agatcgagcc acgttgactt caggtggtct   2880

tctaccagca gctcggaata gttgcactga atctatactt tgcagcactg tctgatgcgt   2940

caacaaaatt gagccatttt tttaaagtaa tagatactaa tagattatct tttctgatgc   3000

actggactga atttttacct caatgtgcaa aggctgatca gcctgaactt tctaaaggac   3060

tttacaagaa gggtttctat ggaatatttt gctagctgtg gtgttcaccg catccctcta   3120

gtcttagaag agaagattat tccttttttc tgtagtcatt gagtggggta tatgcataag   3180

tgggagagaa aaaccaaaca atctacttca gttcagtgta actatttaat tgtgtgggtc   3240

catagacttt ttaatgaaga tttctgactt tgccactgta aatgccttta atgagcatta   3300

atttttgaaa gttttacaga gttttattag ttttactact ttatcttatt gatctctgca   3360

gacttgtgct ggtgcaagta catgctgaca ggcaatttgc actatatttg gctgcagatt   3420

caaataggca gttctcttat ttggtcgact tttgtgaatg tgtgacataa acagatgtaa   3480

tgcatgtcac agtgacggag ataacactgc catgataaaa gtactcatgt ttcccctatt   3540

tggaaaaaaa aattgctttt agtatttttc caagttttca aaagtgccca ttttatgctg   3600

ctgtgtggtt tgttaaatct aaatgatttt taaacttttc tcatagaaac ttaactttgg   3660

caataaacat tttttaaggt ctctcctctt ccttccccaa caatgtagtt ttctagatga   3720

gatttcagta tgattttatc agctatttct tatatatcat aatctggcaa tttctgaaac   3780

cagtcagaaa agacatatat ttccatgcct ttttaaagaa ttatttttac ctgttttata   3840

ttcacagttg gtgtcctgtc actttgtttt aaaataagct agaaccagga tgcttcctta   3900

ttggaaaggc tttgccagtc cttaaggtac aatgagtgat gctgcaactt gcaaatgtac   3960

cagcatttaa aatttctttt cctgggaatc aaggtaactc acacgactac ttgcagtaca   4020

aattttttgc ttctctttcg acatgaaatg tacttggtgg gttttccttc cttttattaa   4080

actaaaactg tgtggaaaag gttgattttt cttaatagat tctggattcc actcacaggg   4140

agatgggatt cctttcttgt ccaaacaaag ggagttgctc taaagcgagc atcagttaaa   4200

atgtagggga aaatgtattc tgtatgtagt gtagataata ctttgtgaat ggacaacagt   4260

tacatagtgt cttggtagca ccagccagtg tttcccagcc cagagtttac tgacttgtaa   4320

ttctctatcc aggacatcag gagtgaggga tggaaaaggg gataaaaggc ctggagccac   4380

actctatatg gctgaggaag gagctaggga aagagataga cacaatgggg tgaaaacaat   4440

tttgccgccc ctgcctggaa actgctggtg gggaaatgat ggtgaagggt gtttgcttga   4500

actcatgaga cggtccaaat ctcataaact agccttctca aaatcccagc aatataaagc   4560

actgtttttc ttcagtcgtt taaataaact tgtaaataca ttgaagttta catttccatg   4620

tgctgttgat caacggcgcc acctgtgttt gctgagactg gtctctgaga gagttttatg   4680

tcgatcgagg cctgttgctc attaagctga gtgcagacgt ccttaatccc tgcagatagt   4740

gggatgaaag caagttct                                                 4758


<210>  140
<211>  861
<212>  PRT
<213>  Homosapiens

<400>  140

Met Glu Ala Leu Gly Pro Gly Pro Pro Ala Ser Leu Phe Gln Pro Pro 
1               5                   10                  15      


Arg Arg Pro Gly Leu Gly Thr Val Gly Lys Pro Ile Arg Leu Leu Ala 
            20                  25                  30          


Asn His Phe Gln Val Gln Ile Pro Lys Ile Asp Val Tyr His Tyr Asp 
        35                  40                  45              


Val Asp Ile Lys Pro Glu Lys Arg Pro Arg Arg Val Asn Arg Glu Val 
    50                  55                  60                  


Val Asp Thr Met Val Arg His Phe Lys Met Gln Ile Phe Gly Asp Arg 
65                  70                  75                  80  


Gln Pro Gly Tyr Asp Gly Lys Arg Asn Met Tyr Thr Ala His Pro Leu 
                85                  90                  95      


Pro Ile Gly Arg Asp Arg Val Asp Met Glu Val Thr Leu Pro Gly Glu 
            100                 105                 110         


Gly Lys Asp Gln Thr Phe Lys Val Ser Val Gln Trp Val Ser Val Val 
        115                 120                 125             


Ser Leu Gln Leu Leu Leu Glu Ala Leu Ala Gly His Leu Asn Glu Val 
    130                 135                 140                 


Pro Asp Asp Ser Val Gln Ala Leu Asp Val Ile Thr Arg His Leu Pro 
145                 150                 155                 160 


Ser Met Arg Tyr Thr Pro Val Gly Arg Ser Phe Phe Ser Pro Pro Glu 
                165                 170                 175     


Gly Tyr Tyr His Pro Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe 
            180                 185                 190         


His Gln Ser Val Arg Pro Ala Met Trp Asn Met Met Leu Asn Ile Asp 
        195                 200                 205             


Val Ser Ala Thr Ala Phe Tyr Arg Ala Gln Pro Ile Ile Glu Phe Met 
    210                 215                 220                 


Cys Glu Val Leu Asp Ile Gln Asn Ile Asn Glu Gln Thr Lys Pro Leu 
225                 230                 235                 240 


Thr Asp Ser Gln Arg Val Lys Phe Thr Lys Glu Ile Arg Gly Leu Lys 
                245                 250                 255     


Val Glu Val Thr His Cys Gly Gln Met Lys Arg Lys Tyr Arg Val Cys 
            260                 265                 270         


Asn Val Thr Arg Arg Pro Ala Ser His Gln Thr Phe Pro Leu Gln Leu 
        275                 280                 285             


Glu Asn Gly Gln Ala Met Glu Cys Thr Val Ala Gln Tyr Phe Lys Gln 
    290                 295                 300                 


Lys Tyr Ser Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val 
305                 310                 315                 320 


Gly Gln Glu Gln Lys His Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile 
                325                 330                 335     


Val Ala Gly Gln Arg Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser 
            340                 345                 350         


Thr Met Ile Lys Ala Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu 
        355                 360                 365             


Ile Ser Arg Leu Val Lys Ser Asn Ser Met Val Gly Gly Pro Asp Pro 
    370                 375                 380                 


Tyr Leu Lys Glu Phe Gly Ile Val Val His Asn Glu Met Thr Glu Leu 
385                 390                 395                 400 


Thr Gly Arg Val Leu Pro Ala Pro Met Leu Gln Tyr Gly Gly Arg Asn 
                405                 410                 415     


Lys Thr Val Ala Thr Pro Asn Gln Gly Val Trp Asp Met Arg Gly Lys 
            420                 425                 430         


Gln Phe Tyr Ala Gly Ile Glu Ile Lys Val Trp Ala Val Ala Cys Phe 
        435                 440                 445             


Ala Pro Gln Lys Gln Cys Arg Glu Asp Leu Leu Lys Ser Phe Thr Asp 
    450                 455                 460                 


Gln Leu Arg Lys Ile Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln 
465                 470                 475                 480 


Pro Cys Phe Cys Lys Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met 
                485                 490                 495     


Phe Lys His Leu Lys Met Thr Tyr Val Gly Leu Gln Leu Ile Val Val 
            500                 505                 510         


Ile Leu Pro Gly Lys Thr Pro Val Tyr Ala Glu Val Lys Arg Val Gly 
        515                 520                 525             


Asp Thr Leu Leu Gly Met Ala Thr Gln Cys Val Gln Val Lys Asn Val 
    530                 535                 540                 


Val Lys Thr Ser Pro Gln Thr Leu Ser Asn Leu Cys Leu Lys Ile Asn 
545                 550                 555                 560 


Ala Lys Leu Gly Gly Ile Asn Asn Val Leu Val Pro His Gln Arg Pro 
                565                 570                 575     


Ser Val Phe Gln Gln Pro Val Ile Phe Leu Gly Ala Asp Val Thr His 
            580                 585                 590         


Pro Pro Ala Gly Asp Gly Lys Lys Pro Ser Ile Ala Ala Val Val Gly 
        595                 600                 605             


Ser Met Asp Gly His Pro Ser Arg Tyr Cys Ala Thr Val Arg Val Gln 
    610                 615                 620                 


Thr Ser Arg Gln Glu Ile Ser Gln Glu Leu Leu Tyr Ser Gln Glu Val 
625                 630                 635                 640 


Ile Gln Asp Leu Thr Asn Met Val Arg Glu Leu Leu Ile Gln Phe Tyr 
                645                 650                 655     


Lys Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile Tyr Tyr Arg Gly Gly 
            660                 665                 670         


Val Ser Glu Gly Gln Met Lys Gln Val Ala Trp Pro Glu Leu Ile Ala 
        675                 680                 685             


Ile Arg Lys Ala Cys Ile Ser Leu Glu Glu Asp Tyr Arg Pro Gly Ile 
    690                 695                 700                 


Thr Tyr Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys Ala 
705                 710                 715                 720 


Asp Lys Thr Glu Arg Val Gly Lys Ser Gly Asn Val Pro Ala Gly Thr 
                725                 730                 735     


Thr Val Asp Ser Thr Ile Thr His Pro Ser Glu Phe Asp Phe Tyr Leu 
            740                 745                 750         


Cys Ser His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr Gln 
        755                 760                 765             


Val Leu Trp Asp Asp Asn Cys Phe Thr Ala Asp Glu Leu Gln Leu Leu 
    770                 775                 780                 


Thr Tyr Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser 
785                 790                 795                 800 


Ile Pro Ala Pro Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala Arg 
                805                 810                 815     


Tyr His Leu Val Asp Lys Asp His Asp Ser Ala Glu Gly Ser His Val 
            820                 825                 830         


Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val 
        835                 840                 845             


Gln Ile His His Asp Thr Gln His Thr Met Tyr Phe Ala 
    850                 855                 860     


<210>  141
<211>  7478
<212>  DNA
<213>  Homosapiens

<400>  141
actggcagct ggccgggcgc tcgcagtggg agctgctgca ggctccgcgg cggcggcaac     60

ggaggctgcg ggggcggcgg cgcgagcggc cgggcttggt aggggagccg agcccggccc    120

gggatcccga gcagcgagag tgtggggtac ctaggcccct cacgctggac ttcacagtct    180

ccgggccgcc tgacctccgc acgggtatat gggatggaag cgggaccctc gggagcagct    240

gcgggcgctt acctgccccc cctgcagcag gtgttccagg cacctcgccg gcctggcatt    300

ggcactgtgg ggaaaccaat caagctcctg gccaattact ttgaggtgga catccctaag    360

atcgacgtgt accactacga ggtggacatc aagccggata agtgtccccg tagagtcaac    420

cgggaagtgg tggaatacat ggtccagcat ttcaagcctc agatctttgg tgatcgcaag    480

cctgtgtatg atggaaagaa gaacatttac actgtcacag cactgcccat tggcaacgaa    540

cgggtcgact ttgaggtgac aatccctggg gaagggaagg atcgaatctt taaggtctcc    600

atcaagtggc tagccattgt gagctggcga atgctgcatg aggccctggt cagcggccag    660

atccctgttc ccttggagtc tgtgcaagcc ctggatgtgg ccatgaggca cctggcatcc    720

atgaggtaca cccctgtggg ccgctccttc ttctcaccgc ctgagggcta ctaccacccg    780

ctggggggtg ggcgcgaggt ctggttcggc tttcaccagt ctgtgcgccc tgccatgtgg    840

aagatgatgc tcaacattga tgtctcagcc actgcctttt ataaggcaca gccagtgatt    900

gagttcatgt gtgaggtgct ggacatcagg aacatagatg agcagcccaa gcccctcacg    960

gactctcagc gcgttcgctt caccaaggag atcaagggcc tgaaggtgga agtcacccac   1020

tgtggacaga tgaagaggaa gtaccgcgtg tgtaatgtta cccgtcgccc tgctagccat   1080

cagacattcc ccttacagct ggagagtgga cagactgtgg agtgcacagt ggcacagtat   1140

ttcaagcaga aatataacct tcagctcaag tatccccatc tgccctgcct acaagttggc   1200

caggaacaaa agcataccta ccttccccta gaggtctgta acattgtggc tgggcagcgc   1260

tgtattaaaa agctgaccga caaccagacc tcgaccatga taaaggccac agctagatcc   1320

gctccagaca gacaggagga gatcagtcgc ctgatgaaga atgccagcta caacttagat   1380

ccctacatcc aggaatttgg gatcaaagtg aaggatgaca tgacggaggt gacagggcga   1440

gtgctgccgg cgcccatctt gcagtacggc ggccggaacc gggccattgc cacacccaat   1500

cagggtgtct gggacatgcg ggggaaacag ttctacaatg ggattgagat caaagtctgg   1560

gccatcgcct gcttcgcacc ccaaaaacag tgtcgagaag aggtgctcaa gaacttcaca   1620

gaccagctgc ggaagatttc caaggatgcg gggatgccta tccagggtca accttgtttc   1680

tgcaaatatg cacagggggc agacagcgtg gagcctatgt tccggcatct caagaacacc   1740

tactcagggc tgcagctcat tattgtcatc ctgccaggga agacgccggt gtatgctgag   1800

gtgaaacgtg tcggagatac actcttggga atggctacgc agtgtgtgca ggtgaagaac   1860

gtggtcaaga cctcacctca gactctgtcc aacctctgcc tcaagatcaa tgtcaaactt   1920

ggtggcatta acaacatcct agtcccacac cagcgctctg ccgtttttca acagccagtg   1980

atattcctgg gagcagatgt tacacacccc ccagcagggg atgggaaaaa accttctatc   2040

acagcagtgg taggcagtat ggatgcccac cccagccgat actgtgctac tgtgcgggta   2100

cagcgaccac ggcaagagat cattgaagac ttgtcctaca tggtgcgtga gctcctcatc   2160

caattctaca agtccacccg tttcaagcct acccgcatca tcttctaccg agatggggtg   2220

cctgaaggcc agctacccca gatactccac tatgagctac tggccattcg tgatgcctgc   2280

atcaaactgg aaaaggacta ccagcctggg atcacttata ttgtggtgca gaaacgccat   2340

cacacccgcc ttttctgtgc tgacaagaat gagcgaattg ggaagagtgg taacatccca   2400

gctgggacca cagtggacac caacatcacc cacccatttg agtttgactt ctatctgtgc   2460

agccacgcag gcatccaggg caccagccga ccatcccatt actatgttct ttgggatgac   2520

aaccgtttca cagcagatga gctccagatc ctgacgtacc agctgtgcca cacttacgta   2580

cgatgcacac gctctgtctc tatcccagca cctgcctact atgcccgcct ggtggctttc   2640

cgggcacgat accacctggt ggacaaggag catgacagtg gagaggggag ccacatatcg   2700

gggcagagca atgggcggga cccccaggcc ctggccaaag ccgtgcaggt tcaccaggat   2760

actctgcgca ccatgtactt cgcttgaagg cagaacgctg ttacctcact ggatagaaga   2820

aagctttcca agccccagga gctgtgccac ccaaatccag aggaagcaag gaggagggag   2880

gtggggtagg gaggagtgta ggatgccttg tttccttcta tagaggtggt gtaagagtgg   2940

ggaacagggc cagcaagaca gaccaccagc cagaaatctc tgatatcaac ctcatgtccc   3000

ccacccctca ccccatcttg tcacatctgg ccctgacccc actggaccaa aaggggcagc   3060

actggtgccc accatacaca caggtgtctc atgtgactca cagtgctaaa gactcatgct   3120

tgacagcttg gtaaggtcaa ctctgtagcc ctgcagacaa aagctggtta ggtttgggtt   3180

tgatacttta gatgggaaag tgaggggctt gagaaagtgg gtgggaggag ggaaggattt   3240

tttaggagcc ttaatcagaa aaggactaga tttgtttaag aagaaaaatg aaaccagacc   3300

cagatcaata ttttaggata ctagatgttt taatgggttc agaatccagt ttgtaggaag   3360

attttttaat ggttttggtt gctcctcccc cagctgccac cccccacctt acccttattc   3420

ctctctgtcc acattttctg ccccacctta cttctcctcc ctgacagaca tccagcccct   3480

agtaatactt aaggcactat ggcacttagc tttgaagtga cacgaccctg tcttccttcc   3540

gcccgctggt gggtaaccag tgccttccct gtaacggtaa tgctgcagaa ctgcaacctt   3600

ttgtaccttt ctttggggaa tggggtgggg gtgggagagg aggtagatgg ggaagaaata   3660

ccccagaccc aacaaacctc cagccagaaa gccagctatt ttgcatttga aggaattgac   3720

ttcctcattc attgagcttt ttaaaagatc acaacctcaa gatggttaaa atccattgac   3780

atttgcactt tcaaacatga caagtctcgg agctgctgag atgacaggcc cctggccttt   3840

ccacttatgc ctccttttct ccttattcct cctacctccc gccccgccca ggtctggagt   3900

tactttcata gcatttttca ctcttggctt cttttctccc ttgatggtca agtctcttat   3960

gtttcaatat ttcttaactg gggtgtctta taacaaaaaa ctcttaggtc taaaatgaga   4020

aaaaagagag aaaacaaaat gttattttta taccataact tgagtgtatt gccaaaattt   4080

ggaaatcctt cccatgcctg atgagtttat atcccagaaa cattgagcca tcagaatgaa   4140

ctgtgtacct gatttgttct ctgacctggc taggtaggga gggggtggtt atcgccccaa   4200

gatggggtcc aggctccatc cttcctctgt gcagataata cctttttctt gctatagcct   4260

ccctcctctg cactgtcctg cactctttct tgcaagtgca tctttttcct tcccctggac   4320

tgtcctctga ccctttggct catcctagat tgcagtgtgt cctgtggaca ggctggggaa   4380

ttttgctgct ccctattgct tctgtttaca aaaatgaatt tttcctggtt tcccactagg   4440

gcatgtgggt gggtggcatg gacttttttt tttttttttt tttgtcttga gacatggggt   4500

ttggctgtct tgcaggactg gagaaggtgg tggttctagc ttggtctctg ttggccttga   4560

agcaagcatc ccccctgccc tttttccttg actgttcatt tttttcctgc cccactgctt   4620

gggatgggga gttgcaactt cagtgtggaa tttcctcttt gaggagcctg ggcttggatc   4680

tatcctgatc tggtgatgaa gccatgatta ctttagacct agcccaggct tggaggccag   4740

ctggaggaag aagggtctaa atcctggcct gtagagttag aactaccatt tcctcccctt   4800

agctgccctt gtatgacccg gatttgctat gcaaaacaat ctatcccagg ttctgttctg   4860

gttggctaca ttgttcagca actcacaaaa cgtagcacaa acattcatta tggagaaagc   4920

atcaggactg ttgagtaact cctcctttac ttttttcctg ctggctacag catggggtgc   4980

cctataggca caagcccagc tgaagaacag aatggagggc tctgggagga ggcagctcac   5040

tggagagcct acattcctta cacaagtgcc taaagagagt gatgctaaca ctccatctgc   5100

cctgtccatt gccttcatat acagtctact tcgtgttctg tcaccctttg gggaggggag   5160

ttctcctggg acagtgggct ctgcatgttc tccacttgga tacattttgg ggctaggatc   5220

agggcactat tcctggaggg tccagtcatt caccagcatt tgcaaatgtc catagggagc   5280

aggtggcagc ctctactccc agcaacaagt ttgtgttctc tccttttctc tctttgcctc   5340

actctctcca gttggttttc agctggggct tgaaatgcat ttttagccct ttgacgtggc   5400

ttatgccatt caagaaataa aaagcaagag aatcagcttt gggcaatgac aagaaatgag   5460

ttcttactct gatttttttg taaaaagata atttttgaga cttgaaaaat accccgacct   5520

tgagattatt cctgtttgaa aggtggtgca tgcagatgga gaagtggtgt tggcagcaag   5580

ctttggctca tgtggatttg gtttaagtgg tgcttcttac ccaagcttca aggaagtgct   5640

tgggggaccc ccagcctcat cctcttagtt gggtctcttg ttccctttgt accactgttt   5700

tgccttcctt ttcctcttct ctctttgcct ggcttccttt cccttttctt ctattcactc   5760

tgcttgcttg ctggccggcc tgcctgcctg cctgcctgcc tgcctgcctg tctgcctatg   5820

tgatgatgaa atctctgcat ggctgcaatg atcccactgt tagctggcag ggtcaggctt   5880

agctccttga ctgcagaaga ccaagaacct gttccccaag cccagagatg tccacctggg   5940

ctggactgcc ctcaagctta tactagagaa gagcaactga cctgcccaac ttgtgtgaag   6000

tcaggagggt ttctggcatt ttccacacct gtccactcct tggagctggt ttctctcatt   6060

gctttttcta aatctggttc tttttctctt tacctggggc ctggcttttc tgagattgtc   6120

ttagggttga gctatttggg tatcctgggt ttgagtgtta ggggatggac ataaaggaaa   6180

aagagtgatg agaagagaat ggagagaatt tgaataaaag gtgggaaagg agagcactgt   6240

tctttgattg tttatccagt ccaacctgat ccattaggga tcgaggtgct acactggcct   6300

ccagggataa gcctggggct actgttgctg ggaacttagg cttaacataa agccgaagaa   6360

ggtacctaga aatttgaaac ttccctaaaa agctcctaat gcccacctgc tagatagctt   6420

ctctgtggcc tcctatttag ctaagcagca gtgtttttgg atactttttt tttctgtttg   6480

tgaataaggc cagcactcaa gatgggcagc caagggtgca ctgactatta gctggcccat   6540

aggatatctg taaggctggt gggacagttt tggacctgga atcatgtgta actaacaagg   6600

ttggacgttt cttccccatc agggtagaaa aatcatctca aactagccaa aaggcagttt   6660

tggaaactac attgggggac gttattttta tttatatatg gggcctaggc caatccagga   6720

tggtagctgg aataccttcc ttcttaaaat ctgatcatgg cagggatatg cagggcactt   6780

tttactattt ggccttctaa gcagattggg aaggaggtat tttctggttt tcgctttcct   6840

ccgacttaat aggacttgcc ttctccctgg gcagggagag aggctgggtt ggtgctctcc   6900

cttactctac tcatactgac ttagagcctc tggctgctgt ttgggcatcc aagaaaggga   6960

ggggaaggaa tgagctaaaa acaaaacaga atgaggtggg aaagggagat tttcttcttt   7020

acagaggaaa ataggaaacc ctccaagaat tgtgcaagta aagacatttg ttgaatgcac   7080

tgagtccctt ggtgtagtag caataaggaa aaatgaaatt actttcctgt gcacacagtc   7140

cagcctaatt ggtatgtgat gttgcactta gcagccatgt ggtgggcatg tgtgactact   7200

ctggttttca ctttagtttc taaacttttt atccctctca agtccagcat ggatggggaa   7260

atgtctctgg atccccacag ctgtgtactt gtttgcattt gtttcccttt gagatttgtg   7320

tttgtgtcct gctttgagct gtaccttgtc cagtccattg tgaaattatc ccagcagctg   7380

taatgtacag ttccttctga agcaagcaac atcagcagca gcagcagcag cagcacaatt   7440

ctgtgtttta taaagacaac agtggcttct atttctaa                           7478


<210>  142
<211>  857
<212>  PRT
<213>  Homosapiens

<400>  142

Met Glu Ala Gly Pro Ser Gly Ala Ala Ala Gly Ala Tyr Leu Pro Pro 
1               5                   10                  15      


Leu Gln Gln Val Phe Gln Ala Pro Arg Arg Pro Gly Ile Gly Thr Val 
            20                  25                  30          


Gly Lys Pro Ile Lys Leu Leu Ala Asn Tyr Phe Glu Val Asp Ile Pro 
        35                  40                  45              


Lys Ile Asp Val Tyr His Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys 
    50                  55                  60                  


Pro Arg Arg Val Asn Arg Glu Val Val Glu Tyr Met Val Gln His Phe 
65                  70                  75                  80  


Lys Pro Gln Ile Phe Gly Asp Arg Lys Pro Val Tyr Asp Gly Lys Lys 
                85                  90                  95      


Asn Ile Tyr Thr Val Thr Ala Leu Pro Ile Gly Asn Glu Arg Val Asp 
            100                 105                 110         


Phe Glu Val Thr Ile Pro Gly Glu Gly Lys Asp Arg Ile Phe Lys Val 
        115                 120                 125             


Ser Ile Lys Trp Leu Ala Ile Val Ser Trp Arg Met Leu His Glu Ala 
    130                 135                 140                 


Leu Val Ser Gly Gln Ile Pro Val Pro Leu Glu Ser Val Gln Ala Leu 
145                 150                 155                 160 


Asp Val Ala Met Arg His Leu Ala Ser Met Arg Tyr Thr Pro Val Gly 
                165                 170                 175     


Arg Ser Phe Phe Ser Pro Pro Glu Gly Tyr Tyr His Pro Leu Gly Gly 
            180                 185                 190         


Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg Pro Ala Met 
        195                 200                 205             


Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Thr Ala Phe Tyr Lys 
    210                 215                 220                 


Ala Gln Pro Val Ile Glu Phe Met Cys Glu Val Leu Asp Ile Arg Asn 
225                 230                 235                 240 


Ile Asp Glu Gln Pro Lys Pro Leu Thr Asp Ser Gln Arg Val Arg Phe 
                245                 250                 255     


Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Val Thr His Cys Gly Gln 
            260                 265                 270         


Met Lys Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg Pro Ala Ser 
        275                 280                 285             


His Gln Thr Phe Pro Leu Gln Leu Glu Ser Gly Gln Thr Val Glu Cys 
    290                 295                 300                 


Thr Val Ala Gln Tyr Phe Lys Gln Lys Tyr Asn Leu Gln Leu Lys Tyr 
305                 310                 315                 320 


Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys His Thr Tyr 
                325                 330                 335     


Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg Cys Ile Lys 
            340                 345                 350         


Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile Lys Ala Thr Ala Arg 
        355                 360                 365             


Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg Leu Met Lys Asn Ala 
    370                 375                 380                 


Ser Tyr Asn Leu Asp Pro Tyr Ile Gln Glu Phe Gly Ile Lys Val Lys 
385                 390                 395                 400 


Asp Asp Met Thr Glu Val Thr Gly Arg Val Leu Pro Ala Pro Ile Leu 
                405                 410                 415     


Gln Tyr Gly Gly Arg Asn Arg Ala Ile Ala Thr Pro Asn Gln Gly Val 
            420                 425                 430         


Trp Asp Met Arg Gly Lys Gln Phe Tyr Asn Gly Ile Glu Ile Lys Val 
        435                 440                 445             


Trp Ala Ile Ala Cys Phe Ala Pro Gln Lys Gln Cys Arg Glu Glu Val 
    450                 455                 460                 


Leu Lys Asn Phe Thr Asp Gln Leu Arg Lys Ile Ser Lys Asp Ala Gly 
465                 470                 475                 480 


Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala Gln Gly Ala 
                485                 490                 495     


Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Thr Tyr Ser Gly 
            500                 505                 510         


Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys Thr Pro Val Tyr Ala 
        515                 520                 525             


Glu Val Lys Arg Val Gly Asp Thr Leu Leu Gly Met Ala Thr Gln Cys 
    530                 535                 540                 


Val Gln Val Lys Asn Val Val Lys Thr Ser Pro Gln Thr Leu Ser Asn 
545                 550                 555                 560 


Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Ile Asn Asn Ile Leu 
                565                 570                 575     


Val Pro His Gln Arg Ser Ala Val Phe Gln Gln Pro Val Ile Phe Leu 
            580                 585                 590         


Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp Gly Lys Lys Pro Ser 
        595                 600                 605             


Ile Thr Ala Val Val Gly Ser Met Asp Ala His Pro Ser Arg Tyr Cys 
    610                 615                 620                 


Ala Thr Val Arg Val Gln Arg Pro Arg Gln Glu Ile Ile Glu Asp Leu 
625                 630                 635                 640 


Ser Tyr Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys Ser Thr Arg 
                645                 650                 655     


Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp Gly Val Pro Glu Gly 
            660                 665                 670         


Gln Leu Pro Gln Ile Leu His Tyr Glu Leu Leu Ala Ile Arg Asp Ala 
        675                 680                 685             


Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly Ile Thr Tyr Ile Val 
    690                 695                 700                 


Val Gln Lys Arg His His Thr Arg Leu Phe Cys Ala Asp Lys Asn Glu 
705                 710                 715                 720 


Arg Ile Gly Lys Ser Gly Asn Ile Pro Ala Gly Thr Thr Val Asp Thr 
                725                 730                 735     


Asn Ile Thr His Pro Phe Glu Phe Asp Phe Tyr Leu Cys Ser His Ala 
            740                 745                 750         


Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr Tyr Val Leu Trp Asp 
        755                 760                 765             


Asp Asn Arg Phe Thr Ala Asp Glu Leu Gln Ile Leu Thr Tyr Gln Leu 
    770                 775                 780                 


Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile Pro Ala Pro 
785                 790                 795                 800 


Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala Arg Tyr His Leu Val 
                805                 810                 815     


Asp Lys Glu His Asp Ser Gly Glu Gly Ser His Ile Ser Gly Gln Ser 
            820                 825                 830         


Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val Gln Val His Gln 
        835                 840                 845             


Asp Thr Leu Arg Thr Met Tyr Phe Ala 
    850                 855         


<210>  143
<211>  3578
<212>  DNA
<213>  Homosapiens

<400>  143
acttccggac gggactcccc tctgtccgcg cctcacatct ccccttcctc tcgcctagtc     60

ctgtgccgtt ttccgtccgc gactcttccg gcccagagct ttcggagtgc ggttgctcag    120

gggaagccgt cgccgccccc gcctcggggc cgagtgagag tgcccgtcgc gtcgcgccgc    180

gtcgcccccc gggccgcctc cttgccgcca gtggcgggct ccgttctccc tcgaagcact    240

ccccccagct ccatgaatgg aaatcggctc cgcaggaccc gctggggccc agcccctact    300

catggtgccc agaagacctg gctatggcac catgggcaaa cccattaaac tgctggctaa    360

ctgttttcaa gttgaaatcc caaagattga tgtctacctc tatgaggtag atattaaacc    420

agacaagtgt cctaggagag tgaacaggga ggtggttgac tcaatggttc agcattttaa    480

agtaactata tttggagacc gtagaccagt ttatgatgga aaaagaagtc tttacaccgc    540

caatccactt cctgtggcaa ctacaggggt agatttagac gttactttac ctggggaagg    600

tggaaaagat cgacctttca aggtgtcaat caaatttgtc tctcgggtga gttggcacct    660

actgcatgaa gtactgacag gacggacctt gcctgagcca ctggaattag acaagccaat    720

cagcactaac cctgtccatg ccgttgatgt ggtgctacga catctgccct ccatgaaata    780

cacacctgtg gggcgttcat ttttctccgc tccagaagga tatgaccacc ctctgggagg    840

gggcagggaa gtgtggtttg gattccatca gtctgttcgg cctgccatgt ggaaaatgat    900

gcttaatatc gatgtttctg ccactgcctt ctacaaagca caacctgtaa ttcagttcat    960

gtgtgaagtt cttgatattc ataatattga tgagcaacca agacctctga ctgattctca   1020

tcgggtaaaa ttcaccaaag agataaaagg tttgaaggtt gaagtgactc attgtggaac   1080

aatgagacgg aaataccgtg tttgtaatgt aacaaggagg cctgccagtc atcaaacctt   1140

tcctttacag ttagaaaacg gccaaactgt ggagagaaca gtagcgcagt atttcagaga   1200

aaagtatact cttcagctga agtacccgca ccttccctgt ctgcaagtcg ggcaggaaca   1260

gaaacacacc tacctgccac tagaagtctg taatattgtg gcagggcaac gatgtatcaa   1320

gaagctaaca gacaatcaga cttccactat gatcaaggca acagcaagat ctgcaccaga   1380

tagacaagag gaaattagca gattggtaag aagtgcaaat tatgaaacag atccatttgt   1440

tcaggagttt caatttaaag ttcgggatga aatggctcat gtaactggac gcgtacttcc   1500

agcacctatg ctccagtatg gaggacggaa tcggacagta gcaacaccga gccatggagt   1560

atgggacatg cgagggaaac aattccacac aggagttgaa atcaaaatgt gggctatcgc   1620

ttgttttgcc acacagaggc agtgcagaga agaaatattg aagggtttca cagaccagct   1680

gcgtaagatt tctaaggatg cagggatgcc catccagggc cagccatgct tctgcaaata   1740

tgcacagggg gcagacagcg tagagcccat gttccggcat ctcaagaaca catattctgg   1800

cctacagctt attatcgtca tcctgccggg gaagacacca gtgtatgcgg aagtgaaacg   1860

tgtaggagac acacttttgg gtatggctac acaatgtgtt caagtcaaga atgtaataaa   1920

aacatctcct caaactctgt caaacttgtg cctaaagata aatgttaaac tcggagggat   1980

caataatatt cttgtacctc atcaaagacc ttctgtgttc cagcaaccag tgatcttttt   2040

gggagccgat gtcactcatc cacctgctgg tgatggaaag aagccttcta ttgctgctgt   2100

tgtaggtagt atggatgcac acccaagcag atactgtgcc acagtaagag ttcagagacc   2160

ccgacaggag atcatccagg acttggcctc catggtccgg gaacttctta ttcaatttta   2220

taagtcaact cggttcaagc ctactcgtat catcttttat cgggatggtg tttcagaggg   2280

gcagtttagg caggtattat attatgaact actagcaatt cgagaagcct gcatcagttt   2340

ggagaaagac tatcaacctg gaataaccta cattgtagtt cagaagagac atcacactcg   2400

attattttgt gctgatagga cagaaagggt tggaagaagt ggcaatatcc cagctggaac   2460

aacagttgat acagacatta cacacccata tgagttcgat ttttacctct gtagccatgc   2520

tggaatacag ggtaccagtc gtccttcaca ctatcatgtt ttatgggatg ataactgctt   2580

tactgcagat gaacttcagc tgctaactta ccagctctgc cacacttacg tacgctgtac   2640

acgatctgtt tctatacctg caccagcgta ttatgctcac ctggtagcat ttagagccag   2700

atatcatctt gtggacaaag aacatgacag tgctgaagga agtcacgttt caggacaaag   2760

caatgggcga gatccacaag ctcttgccaa ggctgtacag attcaccaag ataccttacg   2820

cacaatgtac ttcgcttaaa tagtccaagt atattctctg agaggaagta ctgaaagatg   2880

aattgacata caacgtatgt ttccagtgaa gtcaattgag taaggacacc tccagccata   2940

cagaaaccaa cactgtgtgg gggccaaggt ctgatcctta tgttaataca aggaagattg   3000

tttacttcat caaggaacac agcatcatta tgcaatatga aaccagccaa ctgctttttg   3060

tgcggtctcc tataggaagt atcgcaattg ttttgttttc atttcttgta gtctaaccct   3120

tttaatgcct ttacctcaag ttgcttggca gcacaactat ctttgcaaaa aaaagtaaag   3180

aaaaagtaaa tgatggttta aaaaatacac accttcatga ataatcaaag tgatttttca   3240

gaattatgtg tgcaaaaaat taatgtgcat tcatatattc ttgtaaaagg tgtctgtgta   3300

tttttaaaat atatacatcc atacttcata tgcatatata tctagatctg gattgataat   3360

agatatatat gtgtctgtta tatattttag agttcattcc attggggaat tttctttccc   3420

ttttattcta cccccactac cgcctttatt tctctatttc ccttgccttc atcacctaca   3480

tttttttccc agtcctacca gtgacattca aatgttgatg tatctggttc gtttgaatat   3540

aaaatatggc aaactaaaaa aaaaaaaaaa aaaaaaaa                           3578


<210>  144
<211>  860
<212>  PRT
<213>  Homosapiens

<400>  144

Met Glu Ile Gly Ser Ala Gly Pro Ala Gly Ala Gln Pro Leu Leu Met 
1               5                   10                  15      


Val Pro Arg Arg Pro Gly Tyr Gly Thr Met Gly Lys Pro Ile Lys Leu 
            20                  25                  30          


Leu Ala Asn Cys Phe Gln Val Glu Ile Pro Lys Ile Asp Val Tyr Leu 
        35                  40                  45              


Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys Pro Arg Arg Val Asn Arg 
    50                  55                  60                  


Glu Val Val Asp Ser Met Val Gln His Phe Lys Val Thr Ile Phe Gly 
65                  70                  75                  80  


Asp Arg Arg Pro Val Tyr Asp Gly Lys Arg Ser Leu Tyr Thr Ala Asn 
                85                  90                  95      


Pro Leu Pro Val Ala Thr Thr Gly Val Asp Leu Asp Val Thr Leu Pro 
            100                 105                 110         


Gly Glu Gly Gly Lys Asp Arg Pro Phe Lys Val Ser Ile Lys Phe Val 
        115                 120                 125             


Ser Arg Val Ser Trp His Leu Leu His Glu Val Leu Thr Gly Arg Thr 
    130                 135                 140                 


Leu Pro Glu Pro Leu Glu Leu Asp Lys Pro Ile Ser Thr Asn Pro Val 
145                 150                 155                 160 


His Ala Val Asp Val Val Leu Arg His Leu Pro Ser Met Lys Tyr Thr 
                165                 170                 175     


Pro Val Gly Arg Ser Phe Phe Ser Ala Pro Glu Gly Tyr Asp His Pro 
            180                 185                 190         


Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg 
        195                 200                 205             


Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Thr Ala 
    210                 215                 220                 


Phe Tyr Lys Ala Gln Pro Val Ile Gln Phe Met Cys Glu Val Leu Asp 
225                 230                 235                 240 


Ile His Asn Ile Asp Glu Gln Pro Arg Pro Leu Thr Asp Ser His Arg 
                245                 250                 255     


Val Lys Phe Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Val Thr His 
            260                 265                 270         


Cys Gly Thr Met Arg Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg 
        275                 280                 285             


Pro Ala Ser His Gln Thr Phe Pro Leu Gln Leu Glu Asn Gly Gln Thr 
    290                 295                 300                 


Val Glu Arg Thr Val Ala Gln Tyr Phe Arg Glu Lys Tyr Thr Leu Gln 
305                 310                 315                 320 


Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys 
                325                 330                 335     


His Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg 
            340                 345                 350         


Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile Lys Ala 
        355                 360                 365             


Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg Leu Val 
    370                 375                 380                 


Arg Ser Ala Asn Tyr Glu Thr Asp Pro Phe Val Gln Glu Phe Gln Phe 
385                 390                 395                 400 


Lys Val Arg Asp Glu Met Ala His Val Thr Gly Arg Val Leu Pro Ala 
                405                 410                 415     


Pro Met Leu Gln Tyr Gly Gly Arg Asn Arg Thr Val Ala Thr Pro Ser 
            420                 425                 430         


His Gly Val Trp Asp Met Arg Gly Lys Gln Phe His Thr Gly Val Glu 
        435                 440                 445             


Ile Lys Met Trp Ala Ile Ala Cys Phe Ala Thr Gln Arg Gln Cys Arg 
    450                 455                 460                 


Glu Glu Ile Leu Lys Gly Phe Thr Asp Gln Leu Arg Lys Ile Ser Lys 
465                 470                 475                 480 


Asp Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala 
                485                 490                 495     


Gln Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Thr 
            500                 505                 510         


Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys Thr Pro 
        515                 520                 525             


Val Tyr Ala Glu Val Lys Arg Val Gly Asp Thr Leu Leu Gly Met Ala 
    530                 535                 540                 


Thr Gln Cys Val Gln Val Lys Asn Val Ile Lys Thr Ser Pro Gln Thr 
545                 550                 555                 560 


Leu Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Ile Asn 
                565                 570                 575     


Asn Ile Leu Val Pro His Gln Arg Pro Ser Val Phe Gln Gln Pro Val 
            580                 585                 590         


Ile Phe Leu Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp Gly Lys 
        595                 600                 605             


Lys Pro Ser Ile Ala Ala Val Val Gly Ser Met Asp Ala His Pro Ser 
    610                 615                 620                 


Arg Tyr Cys Ala Thr Val Arg Val Gln Arg Pro Arg Gln Glu Ile Ile 
625                 630                 635                 640 


Gln Asp Leu Ala Ser Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys 
                645                 650                 655     


Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp Gly Val 
            660                 665                 670         


Ser Glu Gly Gln Phe Arg Gln Val Leu Tyr Tyr Glu Leu Leu Ala Ile 
        675                 680                 685             


Arg Glu Ala Cys Ile Ser Leu Glu Lys Asp Tyr Gln Pro Gly Ile Thr 
    690                 695                 700                 


Tyr Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys Ala Asp 
705                 710                 715                 720 


Arg Thr Glu Arg Val Gly Arg Ser Gly Asn Ile Pro Ala Gly Thr Thr 
                725                 730                 735     


Val Asp Thr Asp Ile Thr His Pro Tyr Glu Phe Asp Phe Tyr Leu Cys 
            740                 745                 750         


Ser His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr His Val 
        755                 760                 765             


Leu Trp Asp Asp Asn Cys Phe Thr Ala Asp Glu Leu Gln Leu Leu Thr 
    770                 775                 780                 


Tyr Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile 
785                 790                 795                 800 


Pro Ala Pro Ala Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr 
                805                 810                 815     


His Leu Val Asp Lys Glu His Asp Ser Ala Glu Gly Ser His Val Ser 
            820                 825                 830         


Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val Gln 
        835                 840                 845             


Ile His Gln Asp Thr Leu Arg Thr Met Tyr Phe Ala 
    850                 855                 860 


<210>  145
<211>  3320
<212>  DNA
<213>  Homosapiens

<400>  145
acttccggac gggactcccc tctgtccgcg cctcacatct ccccttcctc tcgcctagtc     60

ctgtgccgtt ttccgtccgc gactcttccg gcccagagct ttcggagtgc ggttgctcag    120

gggaagccgt cgccgccccc gcctcggggc cgagtgagag tgcccgtcgc gtcgcgccgc    180

gtcgcccccc gggccgcctc cttgccgcca gtggcgggct ccgttctccc tcgaagcact    240

ccccccagct ccatgaatgg aaatcggctc cgcaggaccc gctggggccc agcccctact    300

catggtgccc agaagacctg gctatggcac catgggcaaa cccattaaac tgctggctaa    360

ctgttttcaa gttgaaatcc caaagattga tgtctacctc tatgaggtag atattaaacc    420

agacaagtgt cctaggagag tgaacaggta gatttagacg ttactttacc tggggaaggt    480

ggaaaagatc gacctttcaa ggtgtcaatc aaatttgtct ctcgggtgag ttggcaccta    540

ctgcatgaag tactgacagg acggaccttg cctgagccac tggaattaga caagccaatc    600

agcactaacc ctgtccatgc cgttgatgtg gtgctacgac atctgccctc catgaatttc    660

tgccactgcc ttctacaaag cacaacctgt aattcagttc atgtgtgaag ttcttgatat    720

tcataatatt gatgagcaac caagacctct gactgattct catcgggtaa aattcaccaa    780

agagataaaa ggtttgaagg ttgaagtgac tcattgtgga acaatgagac ggaaataccg    840

tgtttgtaat gtaacaagga ggcctgccag tcatcaaacc tttcctttac agttagaaaa    900

cggccaaact gtggagagaa cagtagcgca gtatttcaga gaaaagtata ctcttcagct    960

gaagtacccg caccttccct gtctgcaagt cgggcaggaa cagaaacaca cctacctgcc   1020

actagaagtc tgtaatattg tggcagggca acgatgtatc aagaagctaa cagacaatca   1080

gacttccact atgatcaagg caacagcaag atctgcacca gatagacaag aggaaattag   1140

cagattggta agaagtgcaa attatgaaac agatccattt gttcaggagt ttcaatttaa   1200

agttcgggat gaaatggctc atgtaactgg acgcgtactt ccagcaccta tgctccagta   1260

tggaggacgg aatcggacag tagcaacacc gagccatgga gtatgggaca tgcgagggaa   1320

acaattccac acaggagttg aaatcaaaat gtgggctatc gcttgttttg ccacacagag   1380

gcagtgcaga gaagaaatat tgaagggttt cacagaccag ctgcgtaaga tttctaagga   1440

tgcagggatg cccatccagg gccagccatg cttctgcaaa tatgcacagg gggcagacag   1500

cgtagagccc atgttccggc atctcaagaa cacatattct ggcctacagc ttattatcgt   1560

catcctgccg gggaagacac cagtgtatgc ggaagtgaaa cgtgtaggag acacactttt   1620

gggtatggct acacaatgtg ttcaagtcaa gaatgtaata aaaacatctc ctcaaactct   1680

gtcaaacttg tgcctaaaga taaatgttaa actcggaggg atcaataata ttcttgtacc   1740

tcatcaaaga ccttctgtgt tccagcaacc agtgatcttt ttgggagccg atgtcactca   1800

tccacctgct ggtgatggaa agaagccttc tattgctgct gttgtaggta gtatggatgc   1860

acacccaagc agatactgtg ccacagtaag agttcagaga ccccgacagg agatcatcca   1920

ggacttggcc tccatggtcc gggaacttct tattcaattt tataagtcaa ctcggttcaa   1980

gcctactcgt atcatctttt atcgggatgg tgtttcagag gggcagttta ggcaggtatt   2040

atattatgaa ctactagcaa ttcgagaagc ctgcatcagt ttggagaaag actatcaacc   2100

tggaataacc tacattgtag ttcagaagag acatcacact cgattatttt gtgctgatag   2160

gacagaaagg gttggaagaa gtggcaatat cccagctgga acaacagttg atacagacat   2220

tacacaccca tatgagttcg atttttacct ctgtagccat gctggaatac agggtaccag   2280

tcgtccttca cactatcatg ttttatggga tgataactgc tttactgcag atgaacttca   2340

gctgctaact taccagctct gccacactta cgtacgctgt acacgatctg tttctatacc   2400

tgcaccagcg tattatgctc acctggtagc atttagagcc agatatcatc ttgtggacaa   2460

agaacatgac agtgctgaag gaagtcacgt ttcaggacaa agcaatgggc gagatccaca   2520

agctcttgcc aaggctgtac agattcacca agatacctta cgcacaatgt acttcgctta   2580

aatagtccaa gtatattctc tgagaggaag tactgaaaga tgaattgaca tacaacgtat   2640

gtttccagtg aagtcaattg agtaaggaca cctccagcca tacagaaacc aacactgtgt   2700

gggggccaag gtctgatcct tatgttaata caaggaagat tgtttacttc atcaaggaac   2760

acagcatcat tatgcaatat gaaaccagcc aactgctttt tgtgcggtct cctataggaa   2820

gtatcgcaat tgttttgttt tcatttcttg tagtctaacc cttttaatgc ctttacctca   2880

agttgcttgg cagcacaact atctttgcaa aaaaaagtaa agaaaaagta aatgatggtt   2940

taaaaaatac acaccttcat gaataatcaa agtgattttt cagaattatg tgtgcaaaaa   3000

attaatgtgc attcatatat tcttgtaaaa ggtgtctgtg tatttttaaa atatatacat   3060

ccatacttca tatgcatata tatctagatc tggattgata atagatatat atgtgtctgt   3120

tatatatttt agagttcatt ccattgggga attttctttc ccttttattc tacccccact   3180

accgccttta tttctctatt tcccttgcct tcatcaccta catttttttc ccagtcctac   3240

cagtgacatt caaatgttga tgtatctggt tcgtttgaat ataaaatatg gcaaactaaa   3300

aaaaaaaaaa aaaaaaaaaa                                               3320


<210>  146
<211>  626
<212>  PRT
<213>  Homosapiens

<400>  146

Met Cys Glu Val Leu Asp Ile His Asn Ile Asp Glu Gln Pro Arg Pro 
1               5                   10                  15      


Leu Thr Asp Ser His Arg Val Lys Phe Thr Lys Glu Ile Lys Gly Leu 
            20                  25                  30          


Lys Val Glu Val Thr His Cys Gly Thr Met Arg Arg Lys Tyr Arg Val 
        35                  40                  45              


Cys Asn Val Thr Arg Arg Pro Ala Ser His Gln Thr Phe Pro Leu Gln 
    50                  55                  60                  


Leu Glu Asn Gly Gln Thr Val Glu Arg Thr Val Ala Gln Tyr Phe Arg 
65                  70                  75                  80  


Glu Lys Tyr Thr Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln 
                85                  90                  95      


Val Gly Gln Glu Gln Lys His Thr Tyr Leu Pro Leu Glu Val Cys Asn 
            100                 105                 110         


Ile Val Ala Gly Gln Arg Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr 
        115                 120                 125             


Ser Thr Met Ile Lys Ala Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu 
    130                 135                 140                 


Glu Ile Ser Arg Leu Val Arg Ser Ala Asn Tyr Glu Thr Asp Pro Phe 
145                 150                 155                 160 


Val Gln Glu Phe Gln Phe Lys Val Arg Asp Glu Met Ala His Val Thr 
                165                 170                 175     


Gly Arg Val Leu Pro Ala Pro Met Leu Gln Tyr Gly Gly Arg Asn Arg 
            180                 185                 190         


Thr Val Ala Thr Pro Ser His Gly Val Trp Asp Met Arg Gly Lys Gln 
        195                 200                 205             


Phe His Thr Gly Val Glu Ile Lys Met Trp Ala Ile Ala Cys Phe Ala 
    210                 215                 220                 


Thr Gln Arg Gln Cys Arg Glu Glu Ile Leu Lys Gly Phe Thr Asp Gln 
225                 230                 235                 240 


Leu Arg Lys Ile Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln Pro 
                245                 250                 255     


Cys Phe Cys Lys Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met Phe 
            260                 265                 270         


Arg His Leu Lys Asn Thr Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile 
        275                 280                 285             


Leu Pro Gly Lys Thr Pro Val Tyr Ala Glu Val Lys Arg Val Gly Asp 
    290                 295                 300                 


Thr Leu Leu Gly Met Ala Thr Gln Cys Val Gln Val Lys Asn Val Ile 
305                 310                 315                 320 


Lys Thr Ser Pro Gln Thr Leu Ser Asn Leu Cys Leu Lys Ile Asn Val 
                325                 330                 335     


Lys Leu Gly Gly Ile Asn Asn Ile Leu Val Pro His Gln Arg Pro Ser 
            340                 345                 350         


Val Phe Gln Gln Pro Val Ile Phe Leu Gly Ala Asp Val Thr His Pro 
        355                 360                 365             


Pro Ala Gly Asp Gly Lys Lys Pro Ser Ile Ala Ala Val Val Gly Ser 
    370                 375                 380                 


Met Asp Ala His Pro Ser Arg Tyr Cys Ala Thr Val Arg Val Gln Arg 
385                 390                 395                 400 


Pro Arg Gln Glu Ile Ile Gln Asp Leu Ala Ser Met Val Arg Glu Leu 
                405                 410                 415     


Leu Ile Gln Phe Tyr Lys Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile 
            420                 425                 430         


Phe Tyr Arg Asp Gly Val Ser Glu Gly Gln Phe Arg Gln Val Leu Tyr 
        435                 440                 445             


Tyr Glu Leu Leu Ala Ile Arg Glu Ala Cys Ile Ser Leu Glu Lys Asp 
    450                 455                 460                 


Tyr Gln Pro Gly Ile Thr Tyr Ile Val Val Gln Lys Arg His His Thr 
465                 470                 475                 480 


Arg Leu Phe Cys Ala Asp Arg Thr Glu Arg Val Gly Arg Ser Gly Asn 
                485                 490                 495     


Ile Pro Ala Gly Thr Thr Val Asp Thr Asp Ile Thr His Pro Tyr Glu 
            500                 505                 510         


Phe Asp Phe Tyr Leu Cys Ser His Ala Gly Ile Gln Gly Thr Ser Arg 
        515                 520                 525             


Pro Ser His Tyr His Val Leu Trp Asp Asp Asn Cys Phe Thr Ala Asp 
    530                 535                 540                 


Glu Leu Gln Leu Leu Thr Tyr Gln Leu Cys His Thr Tyr Val Arg Cys 
545                 550                 555                 560 


Thr Arg Ser Val Ser Ile Pro Ala Pro Ala Tyr Tyr Ala His Leu Val 
                565                 570                 575     


Ala Phe Arg Ala Arg Tyr His Leu Val Asp Lys Glu His Asp Ser Ala 
            580                 585                 590         


Glu Gly Ser His Val Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala 
        595                 600                 605             


Leu Ala Lys Ala Val Gln Ile His Gln Asp Thr Leu Arg Thr Met Tyr 
    610                 615                 620                 


Phe Ala 
625     


<210>  147
<211>  1536
<212>  DNA
<213>  Homosapiens

<400>  147
tggttgccta gcaaccggtg gtgccaaaca ctggagctca gagcgggggg cgcggagagc     60

gaagcgggaa aggaggtggt gtctgtgaac aggcctaggg gtttctgacc cttctggttt    120

ctgtgccatg gccacgctga gcgtcaagcc aagtcggcgc ttccagctgc ccgactggca    180

cactaacagc tacctgctat ccaccaatgc ccagctgcag cgagatgctt cccatcagat    240

ccgccaggag gcccgggtgc tccgcaacga gaccaacaac cagaccattt gggatgaaca    300

tgacaacagg actcgactgg tggagaggat tgatactgtc aaccggtgga aggagatgct    360

ggacaagtgt ctgacagatt tagatgccga gatcgatgcc ctgacacaga tgaaggagtc    420

agcagagcaa aacctgcagg ccaagaacct gcctctggat gtggccattg agtgcctgac    480

cctgcgggaa agccggcgag acattgatgt ggtgaaggac cctgtggagg atgagctgca    540

taaagaggtg gaggtcatcg aggccaccaa gaaggccttg caacagaagg tcagccaggc    600

cttcgagcag ctctgcctct tgcaggaagt ccaacagcag ctcaactccg accatcgggg    660

caaaatggag acactagaga tcgacagagg ctgtctctct ctcaacctca gatccccaaa    720

catctcgctg aaggttgacc ccacacgtgt acctgatggc tccaccacac tccagcagtg    780

ggatgacttc agtcggttca acaaggaccg agcggaggct gagatgaagg cagccacaga    840

gctgagggag gccactgctc taactattgc tgagaccaac aacgagcttg aagcccagag    900

agttgcaacg gaatttgcct tcaggaagcg gctgcgggag atggagaaag tgtacagtga    960

gctcaagtgg caagagaaga ataccttgga ggagatcgct gagctgcagg aggacatccg   1020

gcacctggag gaggatctgc gcacaaagct cctgagcctg aagctgtccc atacccggct   1080

agaggccaga acctaccggc ccaacgtgga actctgccgg gaccaggcac agtacggcct   1140

caccgacgag gttcaccagc tagaggcaac catcgctgcc ctgaagcaga agctggcgca   1200

agcacaggac gcactggacg ccctgtgcaa gcacctggcc cggctgcagg ctgacattgc   1260

ctgcaaggcc aactccatgc tgctggacac caagtgcatg gacacacggc gcaagctgac   1320

cgtgcctgct gagaggttcg tgcctgaggt ggacaccttc acacgtacca caaatagcac   1380

cctgagtcca ctcaaaagct gccagctgga gctggcctag ccttggagga ctgcaggagg   1440

agggcagggt tgggtgggca atggaaggag ggaggagaga aatgaatgga ataaatgcag   1500

aggatctcaa aaaaaaaaaa aaaaaaaaaa aaaaaa                             1536


<210>  148
<211>  430
<212>  PRT
<213>  Homosapiens

<400>  148

Met Ala Thr Leu Ser Val Lys Pro Ser Arg Arg Phe Gln Leu Pro Asp 
1               5                   10                  15      


Trp His Thr Asn Ser Tyr Leu Leu Ser Thr Asn Ala Gln Leu Gln Arg 
            20                  25                  30          


Asp Ala Ser His Gln Ile Arg Gln Glu Ala Arg Val Leu Arg Asn Glu 
        35                  40                  45              


Thr Asn Asn Gln Thr Ile Trp Asp Glu His Asp Asn Arg Thr Arg Leu 
    50                  55                  60                  


Val Glu Arg Ile Asp Thr Val Asn Arg Trp Lys Glu Met Leu Asp Lys 
65                  70                  75                  80  


Cys Leu Thr Asp Leu Asp Ala Glu Ile Asp Ala Leu Thr Gln Met Lys 
                85                  90                  95      


Glu Ser Ala Glu Gln Asn Leu Gln Ala Lys Asn Leu Pro Leu Asp Val 
            100                 105                 110         


Ala Ile Glu Cys Leu Thr Leu Arg Glu Ser Arg Arg Asp Ile Asp Val 
        115                 120                 125             


Val Lys Asp Pro Val Glu Asp Glu Leu His Lys Glu Val Glu Val Ile 
    130                 135                 140                 


Glu Ala Thr Lys Lys Ala Leu Gln Gln Lys Val Ser Gln Ala Phe Glu 
145                 150                 155                 160 


Gln Leu Cys Leu Leu Gln Glu Val Gln Gln Gln Leu Asn Ser Asp His 
                165                 170                 175     


Arg Gly Lys Met Glu Thr Leu Glu Ile Asp Arg Gly Cys Leu Ser Leu 
            180                 185                 190         


Asn Leu Arg Ser Pro Asn Ile Ser Leu Lys Val Asp Pro Thr Arg Val 
        195                 200                 205             


Pro Asp Gly Ser Thr Thr Leu Gln Gln Trp Asp Asp Phe Ser Arg Phe 
    210                 215                 220                 


Asn Lys Asp Arg Ala Glu Ala Glu Met Lys Ala Ala Thr Glu Leu Arg 
225                 230                 235                 240 


Glu Ala Thr Ala Leu Thr Ile Ala Glu Thr Asn Asn Glu Leu Glu Ala 
                245                 250                 255     


Gln Arg Val Ala Thr Glu Phe Ala Phe Arg Lys Arg Leu Arg Glu Met 
            260                 265                 270         


Glu Lys Val Tyr Ser Glu Leu Lys Trp Gln Glu Lys Asn Thr Leu Glu 
        275                 280                 285             


Glu Ile Ala Glu Leu Gln Glu Asp Ile Arg His Leu Glu Glu Asp Leu 
    290                 295                 300                 


Arg Thr Lys Leu Leu Ser Leu Lys Leu Ser His Thr Arg Leu Glu Ala 
305                 310                 315                 320 


Arg Thr Tyr Arg Pro Asn Val Glu Leu Cys Arg Asp Gln Ala Gln Tyr 
                325                 330                 335     


Gly Leu Thr Asp Glu Val His Gln Leu Glu Ala Thr Ile Ala Ala Leu 
            340                 345                 350         


Lys Gln Lys Leu Ala Gln Ala Gln Asp Ala Leu Asp Ala Leu Cys Lys 
        355                 360                 365             


His Leu Ala Arg Leu Gln Ala Asp Ile Ala Cys Lys Ala Asn Ser Met 
    370                 375                 380                 


Leu Leu Asp Thr Lys Cys Met Asp Thr Arg Arg Lys Leu Thr Val Pro 
385                 390                 395                 400 


Ala Glu Arg Phe Val Pro Glu Val Asp Thr Phe Thr Arg Thr Thr Asn 
                405                 410                 415     


Ser Thr Leu Ser Pro Leu Lys Ser Cys Gln Leu Glu Leu Ala 
            420                 425                 430 


<210>  149
<211>  1691
<212>  DNA
<213>  Homosapiens

<400>  149
ggcgagcagt ctgcgcgcgg atggccgcag cggcgatggc ggcagcggca ggtggagggg     60

ctggcgcggc ccgctccctc tcgcgcttcc gaggctgcct ggctggtgcg ctgctcgggg    120

actgcgtggg ctccttctac gaggcccacg acaccgtcga cctgacgtca gtcctgcgtc    180

atgtccagag tctggagccg gaccccggca cgcccgggag tgagcggaca gaagccttgt    240

actacacaga tgacacagcc atggccaggg ccctggtgca gtccctgcta gccaaggagg    300

cctttgacga ggtggacatg gctcacagat ttgctcagga gtacaagaaa gaccctgaca    360

ggggctatgg tgctggagta gtcactgtct tcaagaagct cctgaacccc aaatgtcgcg    420

atgtctttga gcctgcccgg gcccagttta acgggaaagg ctcctatggc aatggaggtg    480

ccatgcgggt ggctggcatc tccctggcct atagcagtgt ccaggatgtg cagaagtttg    540

cccggctctc ggcccagctg acacacgcct cctccctggg ttacaatggc gccatcctgc    600

aggccctggc tgtgcacctg gccttgcagg gcgagtcttc cagcgagcac tttctcaagc    660

aactcctggg ccacatggag gatctggagg gtgatgccca gtccgtcttg gatgccaggg    720

agttgggcat ggaggagcgt ccatactcca gccgcctgaa gaagattgga gagcttctag    780

accaggcatc ggtgaccagg gaggaagtgg tgtctgagct agggaatggc attgctgcct    840

ttgagtcggt acccaccgcc atctactgct tcctacgctg catggagcca gaccctgaga    900

tcccttctgc cttcaatagc ctccaaagga ctctcattta ttccatctca cttggtgggg    960

acacagacac cattgccacc atggctgggg ccattgctgg tgcctactat gggatggatc   1020

aggtgccaga gagctggcag caaagctgtg aaggctacga ggagacagac atcctggccc   1080

aaagcctgca ccgtgtcttc cagaagagtt gatgagggct acagctgttg gggctctgcc   1140

aggtcccctg ggaccaacta cagctccaat cagaaaccct gcgcttcctt gagtgtggct   1200

tcccactttt cctgcattgt ggagctgact gagtacaccg gtgaggctgg ggtctctgca   1260

ggggaggtca ctggaacagc gagcaaggga ctggtgcctc gctggtgctg ggtctctggt   1320

ttgctgcaga gccgtaggac actcctggct cctcagtagg acagacagac gcaggcgggt   1380

ttattttgga ggggtacttg tggcattttc ctgtattgtc ttggacatgg gatgtgggga   1440

ggtggaaatg atgagcagta gcatcatttc tccctgttgg gttttagcca gtttgccagc   1500

aagcgcatcc tagcagggtc cccgagcagc aggttgtgtg gatgaaggga caggcacttg   1560

catccagctg atctaggtca cacctggctc ttggctgcca tgtggcttat taacagcttc   1620

cagtggaagt cgcaataaac agtttttggt aaatctcaaa aaaaaaaaaa aaaaaaaaaa   1680

aaaaaaaaaa a                                                        1691


<210>  150
<211>  363
<212>  PRT
<213>  Homosapiens

<400>  150

Met Ala Ala Ala Ala Met Ala Ala Ala Ala Gly Gly Gly Ala Gly Ala 
1               5                   10                  15      


Ala Arg Ser Leu Ser Arg Phe Arg Gly Cys Leu Ala Gly Ala Leu Leu 
            20                  25                  30          


Gly Asp Cys Val Gly Ser Phe Tyr Glu Ala His Asp Thr Val Asp Leu 
        35                  40                  45              


Thr Ser Val Leu Arg His Val Gln Ser Leu Glu Pro Asp Pro Gly Thr 
    50                  55                  60                  


Pro Gly Ser Glu Arg Thr Glu Ala Leu Tyr Tyr Thr Asp Asp Thr Ala 
65                  70                  75                  80  


Met Ala Arg Ala Leu Val Gln Ser Leu Leu Ala Lys Glu Ala Phe Asp 
                85                  90                  95      


Glu Val Asp Met Ala His Arg Phe Ala Gln Glu Tyr Lys Lys Asp Pro 
            100                 105                 110         


Asp Arg Gly Tyr Gly Ala Gly Val Val Thr Val Phe Lys Lys Leu Leu 
        115                 120                 125             


Asn Pro Lys Cys Arg Asp Val Phe Glu Pro Ala Arg Ala Gln Phe Asn 
    130                 135                 140                 


Gly Lys Gly Ser Tyr Gly Asn Gly Gly Ala Met Arg Val Ala Gly Ile 
145                 150                 155                 160 


Ser Leu Ala Tyr Ser Ser Val Gln Asp Val Gln Lys Phe Ala Arg Leu 
                165                 170                 175     


Ser Ala Gln Leu Thr His Ala Ser Ser Leu Gly Tyr Asn Gly Ala Ile 
            180                 185                 190         


Leu Gln Ala Leu Ala Val His Leu Ala Leu Gln Gly Glu Ser Ser Ser 
        195                 200                 205             


Glu His Phe Leu Lys Gln Leu Leu Gly His Met Glu Asp Leu Glu Gly 
    210                 215                 220                 


Asp Ala Gln Ser Val Leu Asp Ala Arg Glu Leu Gly Met Glu Glu Arg 
225                 230                 235                 240 


Pro Tyr Ser Ser Arg Leu Lys Lys Ile Gly Glu Leu Leu Asp Gln Ala 
                245                 250                 255     


Ser Val Thr Arg Glu Glu Val Val Ser Glu Leu Gly Asn Gly Ile Ala 
            260                 265                 270         


Ala Phe Glu Ser Val Pro Thr Ala Ile Tyr Cys Phe Leu Arg Cys Met 
        275                 280                 285             


Glu Pro Asp Pro Glu Ile Pro Ser Ala Phe Asn Ser Leu Gln Arg Thr 
    290                 295                 300                 


Leu Ile Tyr Ser Ile Ser Leu Gly Gly Asp Thr Asp Thr Ile Ala Thr 
305                 310                 315                 320 


Met Ala Gly Ala Ile Ala Gly Ala Tyr Tyr Gly Met Asp Gln Val Pro 
                325                 330                 335     


Glu Ser Trp Gln Gln Ser Cys Glu Gly Tyr Glu Glu Thr Asp Ile Leu 
            340                 345                 350         


Ala Gln Ser Leu His Arg Val Phe Gln Lys Ser 
        355                 360             


<210>  151
<211>  4443
<212>  DNA
<213>  Homosapiens

<400>  151
ggacgccatg ctggggactc tgacacccct gtcttcgctg ctgctgctgc tactggtgct     60

ggtgctgggg tgtgggccgc gggcgtcctc tggtggcggg gccggtgggg cggcgggcta    120

tgccccagtg aagtacatcc agcccatgca gaaaggacct gtgggaccgc ccttccgtga    180

gggcaaaggc cagtacctgg aaatgcctct accgctgctg ccgatggacc tgaagggaga    240

gcccggcccc cctgggaagc ccgggcctcg gggtccccct ggcccccctg gcttcccagg    300

aaaaccaggc atgggaaagc caggactcca tgggcagcct ggccctgctg ggccccctgg    360

cttctcccgg atgggcaagg ctggtccccc agggctccct ggcaaggtcg ggccaccagg    420

gcagccgggg cttcgggggg agccaggaat acgaggggac cagggcctcc ggggaccccc    480

aggaccccct ggcctcccgg gcccctcagg cattactatc cctggaaaac caggtgccca    540

aggggtgcca gggcccccag gattccaggg ggaaccaggg ccccaggggg agcctgggcc    600

cccaggtgat cgaggcctca agggggataa tggagtgggc cagcccgggc tgcctggggc    660

cccagggcag gggggtgccc ccggcccccc cggcctccct ggtccagctg gcttaggcaa    720

acctggtttg gatgggcttc ctggggcccc aggagacaag ggtgagtctg ggcctcctgg    780

agttccaggc cccagggggg agccaggagc tgtgggccca aaaggacctc ctggagtaga    840

cggtgtggga gtcccagggg cagcagggtt gccaggacca cagggcccat caggggccaa    900

aggggagcca gggacccggg gcccccctgg gctgataggc cccactggct atgggatgcc    960

aggactgcca ggccccaagg gggacagggg cccagctggg gtcccaggac tcttggggga   1020

caggggtgag ccaggggagg atggggagcc aggggagcag ggcccacagg gtcttggggg   1080

tccccctgga cttcctgggt ctgcagggct tcctggcaga cgtgggcccc ctgggcctaa   1140

gggtgaggca gggcctggag gacccccagg agtgcctggc attcgaggtg accaggggcc   1200

tagtggcctg gctgggaaac caggggtccc aggtgagagg ggacttcctg gggcccatgg   1260

accccctgga ccaactgggc ccaagggtga gccgggtttc acgggtcgcc ctggaggacc   1320

aggggtggca ggagccctgg ggcagaaagg tgacttgggg ctccctgggc agcctggcct   1380

gaggggtccc tcaggaatcc caggactcca gggtccagct ggccctattg ggccccaagg   1440

cctgccgggc ctgaaggggg aaccaggcct gccagggccc cctggagagg ggagagcagg   1500

ggaacctggc acggctgggc ccacggggcc cccaggggtc cctggctccc ctggaatcac   1560

gggccctccg gggcctcccg ggcccccggg accccctggt gcccctgggg ccttcgatga   1620

gactggcatc gcaggcttgc acctgcccaa cggcggtgtg gagggtgccg tgctgggcaa   1680

ggggggcaag ccacagtttg ggctgggcga gctgtctgcc catgccacac cggccttcac   1740

tgcggtgctc acctcgccct tccccgcctc gggcatgccc gtgaaatttg accggactct   1800

ctacaatggc cacagcggct acaacccagc cactggcatc ttcacctgcc ctgtgggcgg   1860

cgtctactac tttgcttacc atgtgcacgt caagggcacc aacgtgtggg tggccctgta   1920

caagaacaac gtgccggcca cctataccta cgatgagtac aagaagggct acctggacca   1980

ggcatctggt ggggccgtgc tccagctgcg gcccaacgac caggtctggg tgcagatgcc   2040

gtcggaccag gccaacggcc tctactccac ggagtacatc cactcctcct tttcaggatt   2100

cttgctctgc cccacataac ccgcgggggg tgtcctgctg ccctggcctc ctccccttta   2160

gtggtagagc gaccttttca attacaaaga acctcctgga aaaaaaaaca aaagctgaac   2220

agaggcggcc gtggccttgg cccgaggaga ctaacttgct ttctccctgc atgcaggctg   2280

agattgtttc tggaaggggc tggcctgagt ttctttcccc caaatgtctg tgcagtgtca   2340

gggctgcacc ccataggccc tgaggcacac agcccagccc cttgtgagtc ctggcctctg   2400

ctgggccctg aaggagctga gagggagctc aactccccac cccgccacgt ggggagacag   2460

cccttcccac tggctccctg atggcacctg ctggaggaaa ggggcacggc ctccctcaca   2520

gcccttggct ggggctcctc cagctccccc tgggacctcc agcatatgac agtggactaa   2580

ggactgtggg gttttcctcc aaggggaagg gagaagaggg gaccatcgag gtggcgagtg   2640

tggacaccct gccaggactg cagcccccat ggtgatgctg tggcatcaga catgtccgtg   2700

gtgggcacag tgcctgttgc cctgggaaag ggcaacctcc ctttcactgc tccagtggca   2760

gccatgggga aggcagtttg tgagggcttg gggcacagac ctggggcagg aggcagctct   2820

tcacgttcat ccctgtctct cccgggctgc ccccgccagc tctggctgtt tagcttgagg   2880

gcagcacaga ggcccctggg acacctacag gccagaaaga tcaacctctg tgaagtgtct   2940

agaagtatct agtgcagatg gtggcggagg cagaatcgac catcagcaaa catgagcact   3000

cttccctttc tccccttcca cctgctgcgg gctgggctgg ttttctcaat acaaaattgt   3060

aagaggatcc ttgtcacccc agccaggtat ccccaaggca gagcacctct cgtttggccc   3120

tctgaacaag gtgcacgcga gctgggggat gaagacggct cccacttcct tttccttaat   3180

aagaaccata tggtgggtgt atgtgtgtac aagaggggtt catctgtggg ggcttcctct   3240

ccttccaccc tctggttcca atttcctgtt ctaagcagga ctagggccca ggaggctaag   3300

gctgggagag aaagggtgcc aacaggtccc ttgggaatga gttggctctg gacgtttctg   3360

ccctgttccc cgatcagagc tcctctgcag gaaacaggca ggatgcccct cccaacccct   3420

cagtccctac gtcaagcgga gtggataagg ctgagatgag tgctgggagt ggtggacatt   3480

cctgctcgtg caaagatggc cactttcccc gcagctgcag ggcctcgcgc tcggccctcg   3540

ccaggccagc cccactcctt gtaccaagtg tgaactgggg tcattcggtc tgtgatctcg   3600

ttgcactgct ccaagtctgg ctgtgtccag gcggtccatg ttgaaaatgg aggatggctg   3660

ctgacttctg actggctgag cagtgggttc cttcaggttc cttgccaacc ctcctcccct   3720

gcccacaact tctccaaaca aagcaggctg tttgctcact tcttcaaaag gaggaatgat   3780

aacccaaatc tgcccaagtg acacttgaga aggttttggc tggggttcct ggtggatttc   3840

ttactaccta acgcccaaga aaaccaacta aggactctca aaccatacct ggtgggggtt   3900

cttcgctcaa cctcttcttc cctaggtcaa agccactatc atctgatgtg ttagggatgg   3960

gttctgattg gcagaaatta atcagctccc aatgggagcc cacggaacta agtagggtcc   4020

caagaaaaaa aacgggagct atttcacaga gctgagcttc tgccaaattt cattcctcaa   4080

acctttcagg aggggtggtt ggcgtttcta aaatgtttat gggatttgag ttgcaggtgt   4140

ccacttaact gactagcttt gataaacaat gtcagatttt aactatgaaa acgacattac   4200

cttgtgcatt tttatattga ttcctatttt ttttttaaga ttaaagttta aatgttttcc   4260

actagtcatt tcacttctaa cttggtatag gaagcttagc tctctacata cctatcatgt   4320

gccctgtatc acagaagatt caggaaaaat gcacttggga atcaaagaaa atggaacttc   4380

tttttgaaaa gacaagcaac catgttaact gtattgacac atcctcaata aaacctgttg   4440

tat                                                                 4443


<210>  152
<211>  703
<212>  PRT
<213>  Homosapiens

<400>  152

Met Leu Gly Thr Leu Thr Pro Leu Ser Ser Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Val Leu Gly Cys Gly Pro Arg Ala Ser Ser Gly Gly Gly Ala 
            20                  25                  30          


Gly Gly Ala Ala Gly Tyr Ala Pro Val Lys Tyr Ile Gln Pro Met Gln 
        35                  40                  45              


Lys Gly Pro Val Gly Pro Pro Phe Arg Glu Gly Lys Gly Gln Tyr Leu 
    50                  55                  60                  


Glu Met Pro Leu Pro Leu Leu Pro Met Asp Leu Lys Gly Glu Pro Gly 
65                  70                  75                  80  


Pro Pro Gly Lys Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Phe 
                85                  90                  95      


Pro Gly Lys Pro Gly Met Gly Lys Pro Gly Leu His Gly Gln Pro Gly 
            100                 105                 110         


Pro Ala Gly Pro Pro Gly Phe Ser Arg Met Gly Lys Ala Gly Pro Pro 
        115                 120                 125             


Gly Leu Pro Gly Lys Val Gly Pro Pro Gly Gln Pro Gly Leu Arg Gly 
    130                 135                 140                 


Glu Pro Gly Ile Arg Gly Asp Gln Gly Leu Arg Gly Pro Pro Gly Pro 
145                 150                 155                 160 


Pro Gly Leu Pro Gly Pro Ser Gly Ile Thr Ile Pro Gly Lys Pro Gly 
                165                 170                 175     


Ala Gln Gly Val Pro Gly Pro Pro Gly Phe Gln Gly Glu Pro Gly Pro 
            180                 185                 190         


Gln Gly Glu Pro Gly Pro Pro Gly Asp Arg Gly Leu Lys Gly Asp Asn 
        195                 200                 205             


Gly Val Gly Gln Pro Gly Leu Pro Gly Ala Pro Gly Gln Gly Gly Ala 
    210                 215                 220                 


Pro Gly Pro Pro Gly Leu Pro Gly Pro Ala Gly Leu Gly Lys Pro Gly 
225                 230                 235                 240 


Leu Asp Gly Leu Pro Gly Ala Pro Gly Asp Lys Gly Glu Ser Gly Pro 
                245                 250                 255     


Pro Gly Val Pro Gly Pro Arg Gly Glu Pro Gly Ala Val Gly Pro Lys 
            260                 265                 270         


Gly Pro Pro Gly Val Asp Gly Val Gly Val Pro Gly Ala Ala Gly Leu 
        275                 280                 285             


Pro Gly Pro Gln Gly Pro Ser Gly Ala Lys Gly Glu Pro Gly Thr Arg 
    290                 295                 300                 


Gly Pro Pro Gly Leu Ile Gly Pro Thr Gly Tyr Gly Met Pro Gly Leu 
305                 310                 315                 320 


Pro Gly Pro Lys Gly Asp Arg Gly Pro Ala Gly Val Pro Gly Leu Leu 
                325                 330                 335     


Gly Asp Arg Gly Glu Pro Gly Glu Asp Gly Glu Pro Gly Glu Gln Gly 
            340                 345                 350         


Pro Gln Gly Leu Gly Gly Pro Pro Gly Leu Pro Gly Ser Ala Gly Leu 
        355                 360                 365             


Pro Gly Arg Arg Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Pro Gly 
    370                 375                 380                 


Gly Pro Pro Gly Val Pro Gly Ile Arg Gly Asp Gln Gly Pro Ser Gly 
385                 390                 395                 400 


Leu Ala Gly Lys Pro Gly Val Pro Gly Glu Arg Gly Leu Pro Gly Ala 
                405                 410                 415     


His Gly Pro Pro Gly Pro Thr Gly Pro Lys Gly Glu Pro Gly Phe Thr 
            420                 425                 430         


Gly Arg Pro Gly Gly Pro Gly Val Ala Gly Ala Leu Gly Gln Lys Gly 
        435                 440                 445             


Asp Leu Gly Leu Pro Gly Gln Pro Gly Leu Arg Gly Pro Ser Gly Ile 
    450                 455                 460                 


Pro Gly Leu Gln Gly Pro Ala Gly Pro Ile Gly Pro Gln Gly Leu Pro 
465                 470                 475                 480 


Gly Leu Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Glu Gly Arg 
                485                 490                 495     


Ala Gly Glu Pro Gly Thr Ala Gly Pro Thr Gly Pro Pro Gly Val Pro 
            500                 505                 510         


Gly Ser Pro Gly Ile Thr Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
        515                 520                 525             


Pro Pro Gly Ala Pro Gly Ala Phe Asp Glu Thr Gly Ile Ala Gly Leu 
    530                 535                 540                 


His Leu Pro Asn Gly Gly Val Glu Gly Ala Val Leu Gly Lys Gly Gly 
545                 550                 555                 560 


Lys Pro Gln Phe Gly Leu Gly Glu Leu Ser Ala His Ala Thr Pro Ala 
                565                 570                 575     


Phe Thr Ala Val Leu Thr Ser Pro Phe Pro Ala Ser Gly Met Pro Val 
            580                 585                 590         


Lys Phe Asp Arg Thr Leu Tyr Asn Gly His Ser Gly Tyr Asn Pro Ala 
        595                 600                 605             


Thr Gly Ile Phe Thr Cys Pro Val Gly Gly Val Tyr Tyr Phe Ala Tyr 
    610                 615                 620                 


His Val His Val Lys Gly Thr Asn Val Trp Val Ala Leu Tyr Lys Asn 
625                 630                 635                 640 


Asn Val Pro Ala Thr Tyr Thr Tyr Asp Glu Tyr Lys Lys Gly Tyr Leu 
                645                 650                 655     


Asp Gln Ala Ser Gly Gly Ala Val Leu Gln Leu Arg Pro Asn Asp Gln 
            660                 665                 670         


Val Trp Val Gln Met Pro Ser Asp Gln Ala Asn Gly Leu Tyr Ser Thr 
        675                 680                 685             


Glu Tyr Ile His Ser Ser Phe Ser Gly Phe Leu Leu Cys Pro Thr 
    690                 695                 700             


<210>  153
<211>  1278
<212>  DNA
<213>  Homosapiens

<400>  153
gctgaggggc agcggcttag gctccggcgt ctgcaggggt cgccgagcta acccgtggct     60

aggcgagtgg ggcggggcgg ccggcaccat gtcgaggcag gcgaaccgtg gcaccgagag    120

caagaaaatg agctctgagc tcttcaccct gacctatggt gccctggtca cccagctatg    180

taaggactat gaaaatgatg aagatgtgaa taaacagctg gacaaaatgg gctttaacat    240

tggagtccgg ctgattgaag atttcttggc tcggtcaaat gttgggaggt gccatgactt    300

tcgggaaact gcggatgtca ttgccaaggt ggcgttcaag atgtacttgg gcatcactcc    360

aagcattact aattggagcc cagctggtga tgaattctcc ctcattttgg aaaataaccc    420

cttggtggac tttgtggaac ttcctgataa ccactcatcc cttatttatt ccaatctctt    480

gtgtggggtg ttgcggggag ctttggagat ggtccagatg gctgtggagg ccaagtttgt    540

ccaggacacc ctgaaaggag acggtgtgac agaaatccgg atgagattca tcaggcggat    600

tgaggacaat cttccagctg gagaggaata accatcccta caactcgagg atagccatca    660

ggagcactgt tggaatcagc aggcctctgt gctccctctg ccctccagaa ctcagtgact    720

cttgaacatg gatgttatat attcttataa cctgtttcca ttctccattc aaataaagag    780

cagactgcga tatagtccat ttaccccatg tgtgcacatt caggagcgac agtctctgcc    840

cccattccct tgagaggggc tggatgtaat cacctttggt tggactagaa agagctcaaa    900

ccattttaca ttcctgtttg aatttttcca aagcaaaact cactttgacc ccattaagag    960

gcaagcctgg cacatctatc cctgggcctt tagaaagcca tttgcctcaa atggctatag   1020

ggttgtgggg tggagggagg aagggctggg agggagtggg gaggaattgc tagctgtagt   1080

gtgacacatt gtagtgtttg ccaggaaagg agccagtcat gccggaaaca ctgacttctg   1140

ggaagccacc caggtctcat tcctccctgc tgttggaggc aacatctcct ctttttacag   1200

agggtacatc cttttttctt acaaattctt caataaagac acattcttga gtgaaatccc   1260

aaaaaaaaaa aaaaaaaa                                                 1278


<210>  154
<211>  180
<212>  PRT
<213>  Homosapiens

<400>  154

Met Ser Arg Gln Ala Asn Arg Gly Thr Glu Ser Lys Lys Met Ser Ser 
1               5                   10                  15      


Glu Leu Phe Thr Leu Thr Tyr Gly Ala Leu Val Thr Gln Leu Cys Lys 
            20                  25                  30          


Asp Tyr Glu Asn Asp Glu Asp Val Asn Lys Gln Leu Asp Lys Met Gly 
        35                  40                  45              


Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg Ser Asn 
    50                  55                  60                  


Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile Ala Lys 
65                  70                  75                  80  


Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr Asn Trp 
                85                  90                  95      


Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn Pro Leu 
            100                 105                 110         


Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ser Leu Ile Tyr Ser 
        115                 120                 125             


Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val Gln Met 
    130                 135                 140                 


Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp Gly Val 
145                 150                 155                 160 


Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn Leu Pro 
                165                 170                 175     


Ala Gly Glu Glu 
            180 


<210>  155
<211>  3357
<212>  DNA
<213>  Homosapiens

<400>  155
gggttcgcga ccgcagccga gagaccccgg gcgaccggca cctccgagac tcgcgggcca     60

cctgcctcga ccttccccgg agcgcccccg cctccgagtc gctacttgcc gggccgggcc    120

gggccgggcg tgatgcgccg cgggacccct gtcctggcca ctggccgccg ccgccgccgc    180

cgctgagacc ccgagacccc cagtgacgcc gcagccatgg agagcggccc gcgtgcggag    240

ctgggggcgg gcgcaccccc agctgtggtc gccaggaccc ccccagagcc aagaccttct    300

ccagaaggtg acccttcccc cccaccacca ccaatgtcag ccctggtccc cgacactccc    360

ccggacaccc ctcctgccat gaagaatgcc actagctcta agcagctccc actggaacca    420

gagagcccct cagggcaggt cgggcctagg ccagcccccc cgcaggaaga gtccccttcc    480

tctgaagcaa agagcagagg acccacccca ccagccatgg gcccacggga tgccagacct    540

cctcgaagga gcagccagcc atctccaaca gcagtgccag cctccgacag ccctcccacc    600

aagcaagagg tgaagaaggc aggagagaga cacaagctgg caaaggagcg gcgagaagag    660

cgggccaagt acctggcggc caagaaggca gtgtggctgg agaaggagga gaaggccaag    720

gcgctgcggg agaagcagct ccaggagcgc cggcgccggc tggaggagca acgtcttaaa    780

gccgagcaac gccgtgcagc cctggaggaa cggcagcggc agaagctcga gaaaaacaag    840

gagcgctatg aagcagccat ccaacggtca gtgaagaaga cgtgggccga aatccggcag    900

cagcgctggt cctgggcagg ggccctgcac cacagctctc caggacataa gaccagtggg    960

agcaggtgct ccgtgtcggc agttaacctg cccaaacacg tggactctat aatcaacaag   1020

cggctctcaa agtcctctgc cacgctctgg aactccccca gtagaaatcg cagcctgcag   1080

ctgagcgcat gggagagcag catcgtggat cgtctgatga cgcccactct ctccttcctt   1140

gctcggagtc gcagcgcggt cacactgccc cgcaacggcc gggaccaggg taggggctgc   1200

gaccctggga gaggccccac gtggggccgg gcaggggcca gcctggcgcg cgggccgcaa   1260

cccgaccgca ctcatccctc tgcagccgtg ccggtgtgcc cgcgctcggc ctccgccagc   1320

cccctgacgc cgtgcagcgt cacccgaagc gtgcaccgct gcgcccccgc cggtgagcgc   1380

ggggagcgcc gcaagcccaa cgccgggggc agccccgctc cggtgcgccg ccggccggag   1440

gcctcgccgg tgcagaaaaa ggagaagaag gacaaggagc gggaaaacga gaaggagaag   1500

agtgccctag cccgggagcg cagcctcaag aagcgccagt cgctgcccgc ctccccacgt   1560

gcccgcctct ccgccagcac cgcctctgag ctcagcccca aatccaaggc caggccatcc   1620

tctccctcca catcctggca caggcctgcc tccccctgcc ccagcccagg gccaggccac   1680

actctgcctc caaagccacc gtccccccga ggcaccactg catcccccaa ggggcgggtt   1740

cggaggaagg aggaggcaaa ggagagcccc agcgccgcag ggcccgagga caagagccag   1800

agcaagcgca gggccagtaa cgagaaggag tcagcagccc cagcctcacc ggcaccttcg   1860

ccggcgccct cgcccacccc agccccgccc cagaaggagc agccccccgc ggagacccct   1920

acagacgctg ctgtcttgac ctcaccccca gcccctgctc ccccggtgac ccctagcaaa   1980

ccaatggccg gcaccacaga ccgagaagaa gccactcggc tcttggctga gaagcggcgc   2040

caggcccggg agcagcggga gcgcgaggag caggagcgga ggctgcaggc agaaagggac   2100

aagcgaatgc gagaggagca gctggcacgg gaggccgagg cccgggcgga gcgggaggcg   2160

gaggcccgga ggcgggagga gcaggaggca cgagagaagg cgcaggccga gcaggaggag   2220

caggagcggc tgcagaagca gaaagaggag gccgaagctc ggtcgcggga agaggcggag   2280

cggcagcgtc tggagcggga aaagcacttc cagcagcagg agcaagagcg gcaagagcgc   2340

agaaagcgtc tggaggagat catgaagagg actcggaagt cagaagtttc tgaaaccaag   2400

cagaagcagg acagcaagga ggccaacgcc aacggttcca gcccagagcc tgtgaaagct   2460

gtggaggctc ggtccccagg gctgcagaag gaggctgtgc agaaagagga gcccatccca   2520

caggagcctc agtggagtct cccaagcaag gagttgccag cgtccctggt gaatggcctg   2580

cagcctctcc cagcacacca ggagaatggc ttctccacca acggaccctc tggggacaag   2640

agtctgagcc gaacaccaga gacactcctg ccctttgcag aggcagaagc cttcctcaag   2700

aaagctgtgg tgcagtcccc gcaggtcaca gaagtccttt aagagggttt gccttggatc   2760

cgggcacagt tgtgagggct cctctgcatc acctaccagg atgtctggag gagaaaaaga   2820

cagaacaaag atggaagtgg cctgggcccc tgggggtggg tcctctctgt tgtttttaat   2880

ctgcacctta tagactgatg tctctttggc cggagccaga tctgcccctc agtgcattcg   2940

tgtgctcgca cgcgcagaca tcccttctcc cccatacaca catatacact cacagcctct   3000

ctggcctctt cccttgggga ggggccacct gtagtatttg ccttgatttg gtggggtaca   3060

gtggatgtga atactgtaaa tagcttgtgc tcagactcct ctgcgtggag agggtgggtg   3120

caggaggcag accctccccc caaagccccc tggggagatc ttcctctctc tatttaactg   3180

taactgaggg ggatcccagg tctggggatg ggggacacct tgggccacag gatactggtt   3240

gcttcagggg tacccatgcc ccctgccctc gcctggaatc agtgttactg catctgatta   3300

aatgtctcca gaaataaaga ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa      3357


<210>  156
<211>  841
<212>  PRT
<213>  Homosapiens

<400>  156

Met Glu Ser Gly Pro Arg Ala Glu Leu Gly Ala Gly Ala Pro Pro Ala 
1               5                   10                  15      


Val Val Ala Arg Thr Pro Pro Glu Pro Arg Pro Ser Pro Glu Gly Asp 
            20                  25                  30          


Pro Ser Pro Pro Pro Pro Pro Met Ser Ala Leu Val Pro Asp Thr Pro 
        35                  40                  45              


Pro Asp Thr Pro Pro Ala Met Lys Asn Ala Thr Ser Ser Lys Gln Leu 
    50                  55                  60                  


Pro Leu Glu Pro Glu Ser Pro Ser Gly Gln Val Gly Pro Arg Pro Ala 
65                  70                  75                  80  


Pro Pro Gln Glu Glu Ser Pro Ser Ser Glu Ala Lys Ser Arg Gly Pro 
                85                  90                  95      


Thr Pro Pro Ala Met Gly Pro Arg Asp Ala Arg Pro Pro Arg Arg Ser 
            100                 105                 110         


Ser Gln Pro Ser Pro Thr Ala Val Pro Ala Ser Asp Ser Pro Pro Thr 
        115                 120                 125             


Lys Gln Glu Val Lys Lys Ala Gly Glu Arg His Lys Leu Ala Lys Glu 
    130                 135                 140                 


Arg Arg Glu Glu Arg Ala Lys Tyr Leu Ala Ala Lys Lys Ala Val Trp 
145                 150                 155                 160 


Leu Glu Lys Glu Glu Lys Ala Lys Ala Leu Arg Glu Lys Gln Leu Gln 
                165                 170                 175     


Glu Arg Arg Arg Arg Leu Glu Glu Gln Arg Leu Lys Ala Glu Gln Arg 
            180                 185                 190         


Arg Ala Ala Leu Glu Glu Arg Gln Arg Gln Lys Leu Glu Lys Asn Lys 
        195                 200                 205             


Glu Arg Tyr Glu Ala Ala Ile Gln Arg Ser Val Lys Lys Thr Trp Ala 
    210                 215                 220                 


Glu Ile Arg Gln Gln Arg Trp Ser Trp Ala Gly Ala Leu His His Ser 
225                 230                 235                 240 


Ser Pro Gly His Lys Thr Ser Gly Ser Arg Cys Ser Val Ser Ala Val 
                245                 250                 255     


Asn Leu Pro Lys His Val Asp Ser Ile Ile Asn Lys Arg Leu Ser Lys 
            260                 265                 270         


Ser Ser Ala Thr Leu Trp Asn Ser Pro Ser Arg Asn Arg Ser Leu Gln 
        275                 280                 285             


Leu Ser Ala Trp Glu Ser Ser Ile Val Asp Arg Leu Met Thr Pro Thr 
    290                 295                 300                 


Leu Ser Phe Leu Ala Arg Ser Arg Ser Ala Val Thr Leu Pro Arg Asn 
305                 310                 315                 320 


Gly Arg Asp Gln Gly Arg Gly Cys Asp Pro Gly Arg Gly Pro Thr Trp 
                325                 330                 335     


Gly Arg Ala Gly Ala Ser Leu Ala Arg Gly Pro Gln Pro Asp Arg Thr 
            340                 345                 350         


His Pro Ser Ala Ala Val Pro Val Cys Pro Arg Ser Ala Ser Ala Ser 
        355                 360                 365             


Pro Leu Thr Pro Cys Ser Val Thr Arg Ser Val His Arg Cys Ala Pro 
    370                 375                 380                 


Ala Gly Glu Arg Gly Glu Arg Arg Lys Pro Asn Ala Gly Gly Ser Pro 
385                 390                 395                 400 


Ala Pro Val Arg Arg Arg Pro Glu Ala Ser Pro Val Gln Lys Lys Glu 
                405                 410                 415     


Lys Lys Asp Lys Glu Arg Glu Asn Glu Lys Glu Lys Ser Ala Leu Ala 
            420                 425                 430         


Arg Glu Arg Ser Leu Lys Lys Arg Gln Ser Leu Pro Ala Ser Pro Arg 
        435                 440                 445             


Ala Arg Leu Ser Ala Ser Thr Ala Ser Glu Leu Ser Pro Lys Ser Lys 
    450                 455                 460                 


Ala Arg Pro Ser Ser Pro Ser Thr Ser Trp His Arg Pro Ala Ser Pro 
465                 470                 475                 480 


Cys Pro Ser Pro Gly Pro Gly His Thr Leu Pro Pro Lys Pro Pro Ser 
                485                 490                 495     


Pro Arg Gly Thr Thr Ala Ser Pro Lys Gly Arg Val Arg Arg Lys Glu 
            500                 505                 510         


Glu Ala Lys Glu Ser Pro Ser Ala Ala Gly Pro Glu Asp Lys Ser Gln 
        515                 520                 525             


Ser Lys Arg Arg Ala Ser Asn Glu Lys Glu Ser Ala Ala Pro Ala Ser 
    530                 535                 540                 


Pro Ala Pro Ser Pro Ala Pro Ser Pro Thr Pro Ala Pro Pro Gln Lys 
545                 550                 555                 560 


Glu Gln Pro Pro Ala Glu Thr Pro Thr Asp Ala Ala Val Leu Thr Ser 
                565                 570                 575     


Pro Pro Ala Pro Ala Pro Pro Val Thr Pro Ser Lys Pro Met Ala Gly 
            580                 585                 590         


Thr Thr Asp Arg Glu Glu Ala Thr Arg Leu Leu Ala Glu Lys Arg Arg 
        595                 600                 605             


Gln Ala Arg Glu Gln Arg Glu Arg Glu Glu Gln Glu Arg Arg Leu Gln 
    610                 615                 620                 


Ala Glu Arg Asp Lys Arg Met Arg Glu Glu Gln Leu Ala Arg Glu Ala 
625                 630                 635                 640 


Glu Ala Arg Ala Glu Arg Glu Ala Glu Ala Arg Arg Arg Glu Glu Gln 
                645                 650                 655     


Glu Ala Arg Glu Lys Ala Gln Ala Glu Gln Glu Glu Gln Glu Arg Leu 
            660                 665                 670         


Gln Lys Gln Lys Glu Glu Ala Glu Ala Arg Ser Arg Glu Glu Ala Glu 
        675                 680                 685             


Arg Gln Arg Leu Glu Arg Glu Lys His Phe Gln Gln Gln Glu Gln Glu 
    690                 695                 700                 


Arg Gln Glu Arg Arg Lys Arg Leu Glu Glu Ile Met Lys Arg Thr Arg 
705                 710                 715                 720 


Lys Ser Glu Val Ser Glu Thr Lys Gln Lys Gln Asp Ser Lys Glu Ala 
                725                 730                 735     


Asn Ala Asn Gly Ser Ser Pro Glu Pro Val Lys Ala Val Glu Ala Arg 
            740                 745                 750         


Ser Pro Gly Leu Gln Lys Glu Ala Val Gln Lys Glu Glu Pro Ile Pro 
        755                 760                 765             


Gln Glu Pro Gln Trp Ser Leu Pro Ser Lys Glu Leu Pro Ala Ser Leu 
    770                 775                 780                 


Val Asn Gly Leu Gln Pro Leu Pro Ala His Gln Glu Asn Gly Phe Ser 
785                 790                 795                 800 


Thr Asn Gly Pro Ser Gly Asp Lys Ser Leu Ser Arg Thr Pro Glu Thr 
                805                 810                 815     


Leu Leu Pro Phe Ala Glu Ala Glu Ala Phe Leu Lys Lys Ala Val Val 
            820                 825                 830         


Gln Ser Pro Gln Val Thr Glu Val Leu 
        835                 840     


<210>  157
<211>  3610
<212>  DNA
<213>  Homosapiens

<400>  157
cgaggttcgg gctggttgtt ccgttgcgag ctgcagctgc gatctctgtg gtaggcccag     60

aagtgtatgc tgacttgtaa agtgaagaag ccagtggtgc tgcgggtgtt cttttggggt    120

agtgtctggg atccagtacg agttgaatca ttgttcaaat aaggtgtaat tgaaaagtga    180

tcctctcttc agagatgtca aaaacaaaca aatccaagtc tggatctcgc tcttctcgct    240

caagatctgc atcaagatct cgttctcgtt cattttcgaa gtctcggtcc cgaagccgat    300

ctctctctcg ttcaaggaag cgcaggctga gttctaggtc tcgttccaga tcatattctc    360

cagctcataa cagagaaaga aaccacccaa gagtatatca gaatcgggat ttccgaggtc    420

acaacagagg ctatagaagg ccctattatt tccgtgggcg taacagaggc ttttatccat    480

ggggccaata taaccgagga ggctatggaa actaccgctc aaattggcag aattaccggc    540

aagcatacag tcctcgtcga ggccgttcaa gatcccggtc cccaaagaga aggtcccctt    600

caccaaggtc caggagccat tctagaaact ctgataagtc gtcttctgac cggtcaaggc    660

gctcctcatc ctcccgttct tcctccaacc atagccgagt tgaatcttct aagcgcaagt    720

ctgcaaagga gaaaaagtcc tcttctaagg atagccggcc atctcaggct gccggggata    780

accagggaga tgaggtcaag gagcagacat tctctggagg cacctctcaa gatacaaaag    840

catctgagag ctcgaagcca tggccagatg ccacctacgg cactggttct gcatcacggg    900

cctcagcagt ttctgagctg agtcctcggg agcgaagccc agctctcaaa agccccctcc    960

agtctgtggt ggtgaggcgg cggtcacccc gtcctagccc cgtgccaaaa cctagtcctc   1020

cactttccag cacatcccag atgggctcaa ctctgccgag tggtgccggg tatcagtctg   1080

ggacacacca aggtcagttc gaccatggtt ctgggtccct gagtccatcc aaaaagagcc   1140

ctgtgggtaa gagtccacca tccactggct ccacatatgg ctcatctcag aaggaggaga   1200

gtgctgcttc aggaggagca gcctatacaa agaggtatct agaagagcag aagacagaga   1260

atggaaaaga taaggaacag aaacaaacaa ataccgataa agaaaaaata aaagagaaag   1320

ggagcttctc tgacacaggc ttgggtgatg gaaaaatgaa atctgattct tttgctccca   1380

aaactgattc tgagaagcct tttcggggca gtcagtctcc caaaaggtat aagctccgag   1440

atgactttga gaagaagatg gctgacttcc acaaggagga gatggatgat caagataagg   1500

acaaagctaa gggaagaaag gaatctgagt ttgatgatga acccaaattt atgtctaaag   1560

tcataggtgc aaacaaaaac caggaggagg agaagtcagg caaatgggag ggcctggtat   1620

atgcacctcc agggaaggaa aagcagagaa aaacagagga gctggaggag gagtctttcc   1680

cagagagatc caaaaaggaa gatcggggca agagaagcga aggtgggcac aggggctttg   1740

tgcctgagaa gaatttccga gtgactgctt ataaagcagt ccaggagaaa agctcatcac   1800

ctcccccaag aaagacctct gagagccgag acaagctggg agcgaaagga gattttccca   1860

caggaaagtc ttccttttcc attactcgag aggcacaggt caatgtccgg atggactctt   1920

ttgatgagga cctcgcacga cccagtggct tattggctca ggaacgcaag ctttgccgag   1980

atctagtcca tagcaacaaa aaggaacagg agtttcgttc cattttccag cacatacaat   2040

cagctcagtc tcagcgtagc ccctcagaac tgtttgccca acatatagtg accattgttc   2100

accatgttaa agagcatcac tttgggtcct caggaatgac attacatgaa cgctttacta   2160

aatacctaaa gagaggaact gagcaggagg cagccaaaaa caagaaaagc ccagagatac   2220

acaggagaat agacatttcc cccagtacat tcagaaaaca tggtttggct catgatgaaa   2280

tgaaaagtcc ccgggaacct ggctacaagg ctgagggaaa atacaaagat gatcctgttg   2340

atctccgcct tgatattgaa cgtcgtaaaa aacataagga gagagatctt aaacgaggta   2400

aatcgagaga atcagtggat tcccgagact ccagtcactc aagggaaagg tcagctgaaa   2460

aaacagagaa aactcataaa ggatcaaaga aacagaagaa gcatcggaga gcaagagaca   2520

ggtccagatc ctcctcctct tcctcccagt catctcactc ctacaaagca gaagagtaca   2580

ctgaagagac agaggaaaga gaggagagca ccacgggctt tgacaaatca agactgggga   2640

ccaaagactt tgtgggtcca agtgaaagag gaggtggcag agctcgagga acctttcagt   2700

ttcgagccag aggaagaggc tggggcagag gcaactactc tgggaacaat aacaacaaca   2760

gcaacaacga ttttcaaaaa agaaaccggg aagaggagtg ggacccagag tacacaccca   2820

aaagcaagaa gtattacttg catgatgacc gtgaaggcga aggcagtgac aagtgggtga   2880

gccggggccg gggccgagga gcctttcctc ggggtcgggg ccggttcatg ttccggaaat   2940

caagtaccag ccccaagtgg gcccatgaca agttcagtgg ggaggaaggg gagattgaag   3000

acgacgagag tgggacagag aaccgagaag agaaggacaa tatacagccc acaaccgagt   3060

aggggccacc cttgacggga ttcctgccca ggggagagag gcgctgggaa gatggctggt   3120

gaggagctta acagaggaac ctcaagaaga ttctgaaaat cctaccccca ccccccacca   3180

gccgcacaga ttgtactacc gcgagaggca tccctggcgc tgtctcccac tggacagagg   3240

aggctggcca tggggcccag gggtcaggcc cagcttttga gcagaataca acgcattggg   3300

ctttagctgt ttttctcatt tgttggtgtg tggggtgggg gcaggggtag ggcgggagag   3360

cgatgcttgg atttttgttt cctattagaa accaacagtt ttgttctaat ttcatttcat   3420

ttggagctaa gatgactaat ttgatgattt tcgatctctt ttcccctgtc ctgattttaa   3480

aagccccctc cttttttttt tttttttttc tttttttagg catatgtagt aatattagaa   3540

acatttaatt tgggaaactt tgattcttga aagagaaaac aaaagcatgt gaataaactt   3600

tgctcgtgcc                                                          3610


<210>  158
<211>  955
<212>  PRT
<213>  Homosapiens

<400>  158

Met Ser Lys Thr Asn Lys Ser Lys Ser Gly Ser Arg Ser Ser Arg Ser 
1               5                   10                  15      


Arg Ser Ala Ser Arg Ser Arg Ser Arg Ser Phe Ser Lys Ser Arg Ser 
            20                  25                  30          


Arg Ser Arg Ser Leu Ser Arg Ser Arg Lys Arg Arg Leu Ser Ser Arg 
        35                  40                  45              


Ser Arg Ser Arg Ser Tyr Ser Pro Ala His Asn Arg Glu Arg Asn His 
    50                  55                  60                  


Pro Arg Val Tyr Gln Asn Arg Asp Phe Arg Gly His Asn Arg Gly Tyr 
65                  70                  75                  80  


Arg Arg Pro Tyr Tyr Phe Arg Gly Arg Asn Arg Gly Phe Tyr Pro Trp 
                85                  90                  95      


Gly Gln Tyr Asn Arg Gly Gly Tyr Gly Asn Tyr Arg Ser Asn Trp Gln 
            100                 105                 110         


Asn Tyr Arg Gln Ala Tyr Ser Pro Arg Arg Gly Arg Ser Arg Ser Arg 
        115                 120                 125             


Ser Pro Lys Arg Arg Ser Pro Ser Pro Arg Ser Arg Ser His Ser Arg 
    130                 135                 140                 


Asn Ser Asp Lys Ser Ser Ser Asp Arg Ser Arg Arg Ser Ser Ser Ser 
145                 150                 155                 160 


Arg Ser Ser Ser Asn His Ser Arg Val Glu Ser Ser Lys Arg Lys Ser 
                165                 170                 175     


Ala Lys Glu Lys Lys Ser Ser Ser Lys Asp Ser Arg Pro Ser Gln Ala 
            180                 185                 190         


Ala Gly Asp Asn Gln Gly Asp Glu Val Lys Glu Gln Thr Phe Ser Gly 
        195                 200                 205             


Gly Thr Ser Gln Asp Thr Lys Ala Ser Glu Ser Ser Lys Pro Trp Pro 
    210                 215                 220                 


Asp Ala Thr Tyr Gly Thr Gly Ser Ala Ser Arg Ala Ser Ala Val Ser 
225                 230                 235                 240 


Glu Leu Ser Pro Arg Glu Arg Ser Pro Ala Leu Lys Ser Pro Leu Gln 
                245                 250                 255     


Ser Val Val Val Arg Arg Arg Ser Pro Arg Pro Ser Pro Val Pro Lys 
            260                 265                 270         


Pro Ser Pro Pro Leu Ser Ser Thr Ser Gln Met Gly Ser Thr Leu Pro 
        275                 280                 285             


Ser Gly Ala Gly Tyr Gln Ser Gly Thr His Gln Gly Gln Phe Asp His 
    290                 295                 300                 


Gly Ser Gly Ser Leu Ser Pro Ser Lys Lys Ser Pro Val Gly Lys Ser 
305                 310                 315                 320 


Pro Pro Ser Thr Gly Ser Thr Tyr Gly Ser Ser Gln Lys Glu Glu Ser 
                325                 330                 335     


Ala Ala Ser Gly Gly Ala Ala Tyr Thr Lys Arg Tyr Leu Glu Glu Gln 
            340                 345                 350         


Lys Thr Glu Asn Gly Lys Asp Lys Glu Gln Lys Gln Thr Asn Thr Asp 
        355                 360                 365             


Lys Glu Lys Ile Lys Glu Lys Gly Ser Phe Ser Asp Thr Gly Leu Gly 
    370                 375                 380                 


Asp Gly Lys Met Lys Ser Asp Ser Phe Ala Pro Lys Thr Asp Ser Glu 
385                 390                 395                 400 


Lys Pro Phe Arg Gly Ser Gln Ser Pro Lys Arg Tyr Lys Leu Arg Asp 
                405                 410                 415     


Asp Phe Glu Lys Lys Met Ala Asp Phe His Lys Glu Glu Met Asp Asp 
            420                 425                 430         


Gln Asp Lys Asp Lys Ala Lys Gly Arg Lys Glu Ser Glu Phe Asp Asp 
        435                 440                 445             


Glu Pro Lys Phe Met Ser Lys Val Ile Gly Ala Asn Lys Asn Gln Glu 
    450                 455                 460                 


Glu Glu Lys Ser Gly Lys Trp Glu Gly Leu Val Tyr Ala Pro Pro Gly 
465                 470                 475                 480 


Lys Glu Lys Gln Arg Lys Thr Glu Glu Leu Glu Glu Glu Ser Phe Pro 
                485                 490                 495     


Glu Arg Ser Lys Lys Glu Asp Arg Gly Lys Arg Ser Glu Gly Gly His 
            500                 505                 510         


Arg Gly Phe Val Pro Glu Lys Asn Phe Arg Val Thr Ala Tyr Lys Ala 
        515                 520                 525             


Val Gln Glu Lys Ser Ser Ser Pro Pro Pro Arg Lys Thr Ser Glu Ser 
    530                 535                 540                 


Arg Asp Lys Leu Gly Ala Lys Gly Asp Phe Pro Thr Gly Lys Ser Ser 
545                 550                 555                 560 


Phe Ser Ile Thr Arg Glu Ala Gln Val Asn Val Arg Met Asp Ser Phe 
                565                 570                 575     


Asp Glu Asp Leu Ala Arg Pro Ser Gly Leu Leu Ala Gln Glu Arg Lys 
            580                 585                 590         


Leu Cys Arg Asp Leu Val His Ser Asn Lys Lys Glu Gln Glu Phe Arg 
        595                 600                 605             


Ser Ile Phe Gln His Ile Gln Ser Ala Gln Ser Gln Arg Ser Pro Ser 
    610                 615                 620                 


Glu Leu Phe Ala Gln His Ile Val Thr Ile Val His His Val Lys Glu 
625                 630                 635                 640 


His His Phe Gly Ser Ser Gly Met Thr Leu His Glu Arg Phe Thr Lys 
                645                 650                 655     


Tyr Leu Lys Arg Gly Thr Glu Gln Glu Ala Ala Lys Asn Lys Lys Ser 
            660                 665                 670         


Pro Glu Ile His Arg Arg Ile Asp Ile Ser Pro Ser Thr Phe Arg Lys 
        675                 680                 685             


His Gly Leu Ala His Asp Glu Met Lys Ser Pro Arg Glu Pro Gly Tyr 
    690                 695                 700                 


Lys Ala Glu Gly Lys Tyr Lys Asp Asp Pro Val Asp Leu Arg Leu Asp 
705                 710                 715                 720 


Ile Glu Arg Arg Lys Lys His Lys Glu Arg Asp Leu Lys Arg Gly Lys 
                725                 730                 735     


Ser Arg Glu Ser Val Asp Ser Arg Asp Ser Ser His Ser Arg Glu Arg 
            740                 745                 750         


Ser Ala Glu Lys Thr Glu Lys Thr His Lys Gly Ser Lys Lys Gln Lys 
        755                 760                 765             


Lys His Arg Arg Ala Arg Asp Arg Ser Arg Ser Ser Ser Ser Ser Ser 
    770                 775                 780                 


Gln Ser Ser His Ser Tyr Lys Ala Glu Glu Tyr Thr Glu Glu Thr Glu 
785                 790                 795                 800 


Glu Arg Glu Glu Ser Thr Thr Gly Phe Asp Lys Ser Arg Leu Gly Thr 
                805                 810                 815     


Lys Asp Phe Val Gly Pro Ser Glu Arg Gly Gly Gly Arg Ala Arg Gly 
            820                 825                 830         


Thr Phe Gln Phe Arg Ala Arg Gly Arg Gly Trp Gly Arg Gly Asn Tyr 
        835                 840                 845             


Ser Gly Asn Asn Asn Asn Asn Ser Asn Asn Asp Phe Gln Lys Arg Asn 
    850                 855                 860                 


Arg Glu Glu Glu Trp Asp Pro Glu Tyr Thr Pro Lys Ser Lys Lys Tyr 
865                 870                 875                 880 


Tyr Leu His Asp Asp Arg Glu Gly Glu Gly Ser Asp Lys Trp Val Ser 
                885                 890                 895     


Arg Gly Arg Gly Arg Gly Ala Phe Pro Arg Gly Arg Gly Arg Phe Met 
            900                 905                 910         


Phe Arg Lys Ser Ser Thr Ser Pro Lys Trp Ala His Asp Lys Phe Ser 
        915                 920                 925             


Gly Glu Glu Gly Glu Ile Glu Asp Asp Glu Ser Gly Thr Glu Asn Arg 
    930                 935                 940                 


Glu Glu Lys Asp Asn Ile Gln Pro Thr Thr Glu 
945                 950                 955 


<210>  159
<211>  2120
<212>  DNA
<213>  Homosapiens

<400>  159
gggaagcgcg cggccgggcg ggcggccatg gcgcggcacg ctgggaggta gcgcggcggc     60

tgcaggagcg cacagtcggc catggcccgg cggcggcgcc gcgcctgcat cgctctgttc    120

ctggtgctgc tcttcgcctt cggcaccctc atgggtctgc gcacgctcaa ggctccggac    180

ggactcccgg cgctgggccc gggcctggag ctggcgccct ttgagcgacg cccagagggg    240

gcccccgcgc ccgctgccag ggccccggca gcccctgccg cgccgccccc gccgccgccg    300

ccgccccgca ccgcggaccc tggcggctcc cctgggccgg cacccgcgga ggccgagccc    360

gcccccgtgc agagcctgcg cgtctactcg gacctgcacg ccttctacta ctcgtggtac    420

gggagcccgc ggcgcgaggg ccactacatt cactgggacc acgtcatggt gccgcactgg    480

gaccccaaga tctcggccag ctacccccgc ggccgccaca gccccccaga cgacttgggc    540

tccagcttct acccggagct ggggccctac agctcccggg accccgaagt gctgcgggag    600

catatgaccc agctcaagga agccgccatc ggcgtcctgg tcctgtcctg gtacccacct    660

ggcatggctg atgataacgg ggagccctca gatgacctgg tgcccgccat tctggacacc    720

gcccatcagt acagcatcca ggtggccttc cacatccaac cctacaaggg ccgggatgac    780

atcactgtac atgacaacat caagtacatc attgacacaa ctggaaagct gtgaagaact    840

tttgtgatgc caacaacctc atgttcatcc ccagtgtggg gcctggctac atagacacca    900

gcattcggcc ctggaacaac cacaatacgc gcaacagggt caatggcaag tactatgaga    960

cggccctgca ggcggccctg acagtgaggc ccgagatcgt ttccattacc tccttcaatg   1020

agtggcacga gggcacccag attgagaagg ccattcccaa gaagacaccc acccgcctgt   1080

atttggacta cctgcctcac cagcccagcc tgtacctgga gctgacacgc cgctgggcgg   1140

agcacttcat caaagagaag gagcagtggc tcatgtgagg ggcctgtaaa tgggcgtgag   1200

gtgctgatgt ccttgccttg ctggaagatg tcaccatgtg gggttcagct gaggttgtag   1260

ccactcactc gttcccaggt cagaggtcag cagatgggtg tttctgggtg ggccgtcagg   1320

catgggcctg tgcaacacag agcccgttcc tcaggcgagt ggtgctgagg tgctctgtgg   1380

tgatgggaac ggcagaggct ggcaggtgac tgaacttagc ccagggcagc tccacatcct   1440

gggaacactt tcatgtaacc ccttctagtt ttgaactctg cagcaggctg gtgctgtgta   1500

gtggccaccc agtcaccacc cttggaaggg tgtcagggtc tgggctcgca tgcaccctgc   1560

tcccttctgc cagcctgcat cctctcctca ggcctccttc ccacatcatc tgtcttctct   1620

aagttaggga accatatttg agactttcaa aaagggaact tctaggttta agctcctccc   1680

agtagattcc tgaacccaat tatcaggaaa tcatcctgag cactcacagg ttcatttaac   1740

actcactcat caagcacctt cctatgtgct aggtgctggg gaaaacttga ccaaggaaga   1800

gttcctgtcc tgaagcttcc aggacccagc tttccttttc tggtgtggcc ttgtagctag   1860

tgcctgggca caggtgtttt tctttttgca gttttaccta gtgctgggag ttcagttctt   1920

tttcctctag aaaaatacct ctgtgctcca gagcctaatt tttcccagat gcatatttag   1980

ctctagggag aggactagga ggaaatcccc ctccctttag ctgcctgaac tgaggcccac   2040

tcactagagc catgttcagt gctactgtga ttagtagtaa ttaaatatga actggtattc   2100

tcaaaaaaaa aaaaaaaaaa                                               2120


<210>  160
<211>  250
<212>  PRT
<213>  Homosapiens

<400>  160

Met Ala Arg Arg Arg Arg Arg Ala Cys Ile Ala Leu Phe Leu Val Leu 
1               5                   10                  15      


Leu Phe Ala Phe Gly Thr Leu Met Gly Leu Arg Thr Leu Lys Ala Pro 
            20                  25                  30          


Asp Gly Leu Pro Ala Leu Gly Pro Gly Leu Glu Leu Ala Pro Phe Glu 
        35                  40                  45              


Arg Arg Pro Glu Gly Ala Pro Ala Pro Ala Ala Arg Ala Pro Ala Ala 
    50                  55                  60                  


Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Pro Arg Thr Ala Asp Pro 
65                  70                  75                  80  


Gly Gly Ser Pro Gly Pro Ala Pro Ala Glu Ala Glu Pro Ala Pro Val 
                85                  90                  95      


Gln Ser Leu Arg Val Tyr Ser Asp Leu His Ala Phe Tyr Tyr Ser Trp 
            100                 105                 110         


Tyr Gly Ser Pro Arg Arg Glu Gly His Tyr Ile His Trp Asp His Val 
        115                 120                 125             


Met Val Pro His Trp Asp Pro Lys Ile Ser Ala Ser Tyr Pro Arg Gly 
    130                 135                 140                 


Arg His Ser Pro Pro Asp Asp Leu Gly Ser Ser Phe Tyr Pro Glu Leu 
145                 150                 155                 160 


Gly Pro Tyr Ser Ser Arg Asp Pro Glu Val Leu Arg Glu His Met Thr 
                165                 170                 175     


Gln Leu Lys Glu Ala Ala Ile Gly Val Leu Val Leu Ser Trp Tyr Pro 
            180                 185                 190         


Pro Gly Met Ala Asp Asp Asn Gly Glu Pro Ser Asp Asp Leu Val Pro 
        195                 200                 205             


Ala Ile Leu Asp Thr Ala His Gln Tyr Ser Ile Gln Val Ala Phe His 
    210                 215                 220                 


Ile Gln Pro Tyr Lys Gly Arg Asp Asp Ile Thr Val His Asp Asn Ile 
225                 230                 235                 240 


Lys Tyr Ile Ile Asp Thr Thr Gly Lys Leu 
                245                 250 


<210>  161
<211>  2341
<212>  DNA
<213>  Homosapiens

<400>  161
agtctaaagc ctggctccct tccggcctgg cgcgctacgg ttcccgcagg cgctccgctt     60

cagcaccgcg ggcgtggaca gctccggggc gcgaggctct gggactcatc tgcaggaagt    120

gaacctggca ggaggcttgc ttcaggtttt taggaaccat ttttgcaatt ggagatgttt    180

gtgaggaaaa aaatctctgt tgaggggggt actgtgtgtc tctgaagtgg cctctgtgtt    240

gcgtctcagg cgtcctggtc ctgtcctggt acccacctgg catggctgat gataacgggg    300

agccctcaga tgacctggtg cccgccattc tggacaccgc ccatcagtac agcatccagg    360

tatggctccc atggtgcatt ttaccgctat aagaacagca tgggcaagag cctcccactc    420

ttttatatct acgactcata cctgacgtcc cctgaggcct gggcccacct cctgacacca    480

aacgggcccc attcgatccg caacacgccc tacgatgggg tcttcatagc gctgctggtg    540

gaggagggcc acacccacga tatcctggcc gccggatttg acggcatgta cacctacttt    600

gcctccaatg gtttctcctt tggttcttcc catcagaact ggaaagctgt gaagaacttt    660

tgtgatgcca acaacctcat gttcatcccc agtgtggggc ctggctacat agacaccagc    720

attcggccct ggaacaacca caatacgcgc aacagggtca atggcaagta ctatgagacg    780

gccctgcagg cggccctgac agtgaggccc gagatcgttt ccattacctc cttcaatgag    840

tggcacgagg gcacccagat tgagaaggcc attcccaaga agacacccac ccgcctgtat    900

ttggactacc tgcctcacca gcccagcctg tacctggagc tgacacgccg ctgggcggag    960

cacttcatca aagagaagga gcagtggctc atgtgagggg cctgtaaatg ggcgtgaggt   1020

gctgatgtcc ttgccttgct ggaagatgtc accatgtggg gttcagctga ggttgtagcc   1080

actcactcgt tcccaggtca gaggtcagca gatgggtgtt tctgggtggg ccgtcaggca   1140

tgggcctgtg caacacagag cccgttcctc aggcgagtgg tgctgaggtg ctctgtggtg   1200

atgggaacgg cagaggctgg caggtgactg aacttagccc agggcagctc cacatcctgg   1260

gaacactttc atgtaacccc ttctagtttt gaactctgca gcaggctggt gctgtgtagt   1320

ggccacccag tcaccaccct tggaagggtg tcagggtctg ggctcgcatg caccctgctc   1380

ccttctgcca gcctgcatcc tctcctcagg cctccttccc acatcatctg tcttctctaa   1440

gttagggaac catatttgag actttcaaaa agggaacttc taggtttaag ctcctcccag   1500

tagattcctg aacccaatta tcaggaaatc atcctgagca ctcacaggtt catttaacac   1560

tcactcatca agcaccttcc tatgtgctag gtgctgggga aaacttgacc aaggaagagt   1620

tcctgtcctg aagcttccag gacccagctt tccttttctg gtgtggcctt gtagctagtg   1680

cctgggcaca ggtgtttttc tttttgcagt tttacctagt gctgggagtt cagttctttt   1740

tcctctagaa aaatacctct gtgctccaga gcctaatttt tcccagatgc atatttagct   1800

ctagggagag gactaggagg aaatccccct ccctttagct gcctgaactg actgaggccc   1860

actcactaga gccatgttca gtgctactgt gattagtagt aattaaatat gaactggtat   1920

tctcaagtaa gcattccttt tgctctcttt aagacctcac agattctgac cttagattct   1980

gtgacaaact gatacaggag ctgggctggc tatggcttta ccacaacaag taggtttgct   2040

taagaaatta ctaaacaatg gctgggcgtg gtggctcact cctgtaatcc cagcactttg   2100

ggaggccgag atgggcggat cacgaggtca ggagatcgag accatcctgg ctaacagggt   2160

gaaaccacgt ctctactaaa aatacaaaaa aattagccag gcgtagtggt gggcgcctgt   2220

agtcccagct acttgggagg ctgaggcagg agaatggcgt gaacccggga ggcggagctt   2280

gcagtgagcc gagatcacgc cactgcactc cagcctgggc gacagagcga gactccgtct   2340

c                                                                   2341


<210>  162
<211>  235
<212>  PRT
<213>  Homosapiens

<400>  162

Met Ile Thr Gly Ser Pro Gln Met Thr Trp Cys Pro Pro Phe Trp Thr 
1               5                   10                  15      


Pro Pro Ile Ser Thr Ala Ser Arg Tyr Gly Ser His Gly Ala Phe Tyr 
            20                  25                  30          


Arg Tyr Lys Asn Ser Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr 
        35                  40                  45              


Asp Ser Tyr Leu Thr Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro 
    50                  55                  60                  


Asn Gly Pro His Ser Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile 
65                  70                  75                  80  


Ala Leu Leu Val Glu Glu Gly His Thr His Asp Ile Leu Ala Ala Gly 
                85                  90                  95      


Phe Asp Gly Met Tyr Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly 
            100                 105                 110         


Ser Ser His Gln Asn Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn 
        115                 120                 125             


Asn Leu Met Phe Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser 
    130                 135                 140                 


Ile Arg Pro Trp Asn Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys 
145                 150                 155                 160 


Tyr Tyr Glu Thr Ala Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile 
                165                 170                 175     


Val Ser Ile Thr Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu 
            180                 185                 190         


Lys Ala Ile Pro Lys Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu 
        195                 200                 205             


Pro His Gln Pro Ser Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu 
    210                 215                 220                 


His Phe Ile Lys Glu Lys Glu Gln Trp Leu Met 
225                 230                 235 


<210>  163
<211>  1871
<212>  DNA
<213>  Homosapiens

<400>  163
cgggcctggg cggatgtctc cggcgcgtcg gtgcaggggg atgagggccg cggtggctgc     60

cagcgtgggg ttgagcgagg ggcctgctgg ctcccggagc ggtcgcctct tccgcccgcc    120

gagtcccgct ccggcggccc ccggcgcccg gctgttgcgg ctcccgggga gcggggccgt    180

gcaggccgcg agcccggagc gcgccggctg gaccgaggcg ctgcgggccg ccgtggccga    240

gctgcgcgcc ggcgccgtgg tggccgtccc caccgatacg ctgtacggcc tggcctgcgc    300

ggcgagctgc tcggcggctc tgcgcgctgt gtaccgcctc aagggtcgca gcgaggccaa    360

gcctctggcc gtatgcctcg gccgcgtggc cgacgtctac agatactgcc gtgtgagagt    420

acctgagggg ctcctgaaag acctactgcc aggaccagtg accctggtga tggaacgctc    480

ggaggagctc aacaaggacc taaacccttt tacgcctctt gtaggcattc ggattcctga    540

tcatgctttt atgcaagact tggctcagat gtttgagggt ccgcttgctc tcactagtgc    600

caacctcagc tcccaggcca gttctctgaa tgtcgaggag ttccaggatc tctggcctca    660

gttgtccttg gttattgatg ggggacaaat tggggatggc cagagccccg agtgtcgcct    720

tggctcaact gtggttgatt tgtctgtgcc cggaaagttt ggcatcattc gtccaggctg    780

tgccctggaa agtactacag ccatcctcca acagaagtac ggactgctcc cctcacatgc    840

gtcctacctg tgaaactctg ggaagcagga aggcccaaga cctggtgctg gatactatgt    900

gtctgtccac tgacgactgt caaggcctca tttgcagagg ccaccggagc tagggcacta    960

gcctgacttt taaggcagtg tgtctttctg agcactgtag accaagccct tggagctgct   1020

ggtttagcct tgcacctggg gaaaggatgt atttatttgt attttcatat atcagccaaa   1080

agctgaatgg aaaagttaag aacattccta ggtggcctta ttctaataag tttcttctgt   1140

ctgttttgtt tttcaattga aaagtaatta aataacagat ttagaatcta gtgagagcct   1200

cctctctggt gggtggtggc atttaaggtt caaaccagcc agaagtgctg gtgctgttta   1260

aaaagtctca ggtggctgcg tgtggtggct catgcctgta atcccaacat tctgggaggc   1320

ccaggcggga gaactgcttg agcccaggag ttcagaatca gcctgggcaa catagcaata   1380

ctccgtctca taaaaattaa taaataaaaa gtctcaggtg accaaaggct cctgaagcta   1440

gaaccaggtt tggataaaga ttgaagagcc acaggccact cttccctctg agccattggg   1500

cctagtggtg tcatgtattg taattgctcg cagggagagc agtctttttg gtgtaatagt   1560

gggatgtctg cttagttggc aggggttcag tccaaatgga agaatattgg gaaataaacc   1620

tccactatcc tttatagcca gggacttttt tcttatttat tcataaaata aattatagtt   1680

aattataccc ataacacctt tatttaaatc cagtgttctc cgcagccttt tgtctattta   1740

tatgtgtacc aagtgttaaa cataattatt attgggcatt tgaactttgt ttttctttaa   1800

agaaatgctg ctattaaaca tatttgtaaa tggtttaaaa aaaaaaaaaa aaaaaaaaaa   1860

aaaaaaaaaa a                                                        1871


<210>  164
<211>  279
<212>  PRT
<213>  Homosapiens

<400>  164

Met Ser Pro Ala Arg Arg Cys Arg Gly Met Arg Ala Ala Val Ala Ala 
1               5                   10                  15      


Ser Val Gly Leu Ser Glu Gly Pro Ala Gly Ser Arg Ser Gly Arg Leu 
            20                  25                  30          


Phe Arg Pro Pro Ser Pro Ala Pro Ala Ala Pro Gly Ala Arg Leu Leu 
        35                  40                  45              


Arg Leu Pro Gly Ser Gly Ala Val Gln Ala Ala Ser Pro Glu Arg Ala 
    50                  55                  60                  


Gly Trp Thr Glu Ala Leu Arg Ala Ala Val Ala Glu Leu Arg Ala Gly 
65                  70                  75                  80  


Ala Val Val Ala Val Pro Thr Asp Thr Leu Tyr Gly Leu Ala Cys Ala 
                85                  90                  95      


Ala Ser Cys Ser Ala Ala Leu Arg Ala Val Tyr Arg Leu Lys Gly Arg 
            100                 105                 110         


Ser Glu Ala Lys Pro Leu Ala Val Cys Leu Gly Arg Val Ala Asp Val 
        115                 120                 125             


Tyr Arg Tyr Cys Arg Val Arg Val Pro Glu Gly Leu Leu Lys Asp Leu 
    130                 135                 140                 


Leu Pro Gly Pro Val Thr Leu Val Met Glu Arg Ser Glu Glu Leu Asn 
145                 150                 155                 160 


Lys Asp Leu Asn Pro Phe Thr Pro Leu Val Gly Ile Arg Ile Pro Asp 
                165                 170                 175     


His Ala Phe Met Gln Asp Leu Ala Gln Met Phe Glu Gly Pro Leu Ala 
            180                 185                 190         


Leu Thr Ser Ala Asn Leu Ser Ser Gln Ala Ser Ser Leu Asn Val Glu 
        195                 200                 205             


Glu Phe Gln Asp Leu Trp Pro Gln Leu Ser Leu Val Ile Asp Gly Gly 
    210                 215                 220                 


Gln Ile Gly Asp Gly Gln Ser Pro Glu Cys Arg Leu Gly Ser Thr Val 
225                 230                 235                 240 


Val Asp Leu Ser Val Pro Gly Lys Phe Gly Ile Ile Arg Pro Gly Cys 
                245                 250                 255     


Ala Leu Glu Ser Thr Thr Ala Ile Leu Gln Gln Lys Tyr Gly Leu Leu 
            260                 265                 270         


Pro Ser His Ala Ser Tyr Leu 
        275                 


<210>  165
<211>  822
<212>  DNA
<213>  Homosapiens

<400>  165
aaggagaccg gtggggacgg ggcggggcgc agccttgcga agccctaacg cagcgctggg     60

gaggggggcg gccgaaaggg gggcggtggt cgggccgcgc aagcggagat ggaatggggc    120

ccgggctcag actggtcacg gggggaggct gccggcgtgg accgcgggaa ggcggggctg    180

gggctcggcg ggaggccacc cccacagccg ccccgggagg agcgcgccca gcagctgctg    240

gacgcggtgg agcagcggca gcggcagctc ctggacacca tcgcagcctg cgaggagatg    300

ttacggcagc tgggccgccg gcgcccggag ccggctggtg gcgggaacgt ctcagccaaa    360

cctggagcgc ccccccagcc ggctgtctcc gccagaggcg gctttccaaa ggatgctggc    420

gatggagctg cggagccctg accatccccg agcagaatac cctgacttct ctccctcccc    480

agggccggtg gctggactct gaacaactcc cttcagtaaa ggggccagtc ttcactggca    540

gtggctggta cttggctctc agcctggagt ggcagctctg ctagcagctg ggttcactcc    600

cacttcatcc tggctgaaag cagtgctgtg ctttgaaatg cagccaatga atacccagtc    660

tgattaccca gatttgggca gaccagcagt gctcgccaga gtggtctggc ctgctatggg    720

ggatccaggt ggtgttacat gtccatttca tgttttgggg gcttttagcc ccacaaaaca    780

ccttcagtag agccttgatt aaaaggaaac ctgcagactc tc                       822


<210>  166
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  166

Met Gly Pro Gly Leu Arg Leu Val Thr Gly Gly Gly Cys Arg Arg Gly 
1               5                   10                  15      


Pro Arg Glu Gly Gly Ala Gly Ala Arg Arg Glu Ala Thr Pro Thr Ala 
            20                  25                  30          


Ala Pro Gly Gly Ala Arg Pro Ala Ala Ala Gly Arg Gly Gly Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Pro Gly His His Arg Ser Leu Arg Gly Asp Val Thr 
    50                  55                  60                  


Ala Ala Gly Pro Pro Ala Pro Gly Ala Gly Trp Trp Arg Glu Arg Leu 
65                  70                  75                  80  


Ser Gln Thr Trp Ser Ala Pro Pro Ala Gly Cys Leu Arg Gln Arg Arg 
                85                  90                  95      


Leu Ser Lys Gly Cys Trp Arg Trp Ser Cys Gly Ala Leu Thr Ile Pro 
            100                 105                 110         


Glu Gln Asn Thr Leu Thr Ser Leu Pro Pro Gln Gly Arg Trp Leu Asp 
        115                 120                 125             


Ser Glu Gln Leu Pro Ser Val Lys Gly Pro Val Phe Thr Gly Ser Gly 
    130                 135                 140                 


Trp Tyr Leu Ala Leu Ser Leu Glu Trp Gln Leu Cys 
145                 150                 155     


<210>  167
<211>  3302
<212>  DNA
<213>  Homosapiens

<400>  167
cggtgctgcc gccgttgccg ggagccgcgg agacaagtca ttacgttttc atttctcaca     60

actgggctga gcacaactga accatggggg aacacagtcc agacaacaac atcatctact    120

ttgaggcaga ggaagatgag ctgacccccg atgataaaat gctcaggttt gtggataaaa    180

acggactggt gccttcctca tctggaactg tttatgatag gaccactgtt cttattgagc    240

aggaccctgg cactttggag gatgaagatg acgacggaca gtgcggagaa cacttgcctt    300

ttctagtagg gggtgaagag ggctttcacc tgatagatca tgaagcaatg tcccagggtt    360

atgtgcagca cattatctca ccagatcaga ttcatttgac aataaaccct ggttccacac    420

ccatgccaag aaatattgaa ggtgcaaccc tcactctgca gtcggaatgt ccggaaacaa    480

aacgtaaaga agtaaagcgg taccaatgta cctttgaggg ctgtccccgc acctacagca    540

cagcaggcaa cctgcgaacc caccagaaga ctcaccgagg agagtacacc tttgtctgta    600

atcaggaggg ctgtggcaaa gccttcctta cctctcacag cctcaggatc cacgtgcgag    660

tgcacacgaa ggagaagcca tttgagtgtg acgtgcaggg ctgtgagaag gcattcaaca    720

cactgtacag gctgaaagca catcagaggc ttcacacagg gaaaacgttt aactgtgaat    780

ctgaaggctg cagcaaatac ttcaccacac tcagtgatct gaggaagcac attcgaactc    840

atacagggga aaagccattt cggtgcgatc acgatggctg tggaaaagca tttgcagcaa    900

gccaccacct taaaactcac gttcgtacac atactggtga aagacccttc ttctgcccca    960

gtaatggctg tgagaaaaca ttcagcactc aatacagtct caaaagtcac atgaaaggtc   1020

atgataacaa aggacactca tacaatgcac ttccacaaca caatggatca gaggatacaa   1080

atcactcact ttgtctaagt gacttgagcc ttctgtccac agattctgaa ttgcgagaaa   1140

attccagtac gacccagggc caggacctca gcacaatttc accagcaatc atctttgaat   1200

caatgttcca gaattcagat gatacggcaa ttcaggaaga tcctcaacag acagcttcct   1260

tgactgaaag ttttaatggt gatgcagagt cagtcagtga tgttccgcca tccacaggaa   1320

attcagcatc tttatctctt ccacttgtac tgcaacctgg cctctccgag ccaccccagc   1380

ctctactacc tgcctcagct ccgtctgctc ctccgcctgc tccctcccta ggacctggct   1440

cccagcaagc tgcatttggc aacccccctg ctctcttaca acctccagaa gtgcctgttc   1500

cccacagcac acagtttgct gctaatcatc aagagtttct tccgcacccc caggcaccgc   1560

agcccattgt accaggactt tctgttgttg ctggggcttc tgcatcagca gcggcagtgg   1620

catcagctgt ggcagcacca gccccaccac aaagtactac tgagcccctg ccagccatgg   1680

tccagactct gcccctgggt gccaactctg tcctaactaa taatcccaca ataaccatca   1740

ccccaactcc caacacagct atcctgcagt ccagcctagt catgggagaa cagaacttac   1800

aatggatatt aaatggtgcc accagttctc cacaaaacca agaacaaatt cagcaagcat   1860

ctaaagttga gaaggtgttt tttaccactg cagtaccagt agccagtagc ccagggagct   1920

ctgtccagca gattggcctc agtgttcctg tgatcatcat caaacaagaa gaggcatgtc   1980

agtgtcagtg tgcatgccgg gactctgcaa aggagcgggc atccagcagg agaaagggct   2040

gctcctcccc accccctcca gagccgagcc cccaggctcc tgatgggccc agcctgcagc   2100

tcccagcgca gactttctct tcagcccctg ttcccgggtc atcatcctct accttgccct   2160

cctcctgtga gcaaagccga caagcagaga ctccttcaga ccctcagaca gaaacattaa   2220

gtgccatgga tgtgtcagag tttctatccc tccagagcct ggacaccccg tccaatctga   2280

ttcccattga agcactactg cagggggagg aggagatggg cctcaccagc agcttctcca   2340

agtgaagggc ccatgtgtgc tcacctctgg gaaaagcggg tgagcaggag gcatgaggta   2400

caatgcctgc catcatgggt cagaaatttg aaggatgaag aaatctactg tttgaaatcc   2460

tcacctttca gacgtatttt ctttattcac atcccaggag catccatttt aaggaactat   2520

tctttggaaa aaaacaaaaa acaaaaaaaa caacaaaaaa agctaagtta taagtgaact   2580

gtttggctgc actgtatgtc acttttgctt gttgtcatgt gaacttggaa actaaggtta   2640

ctcgtgtgca taaaaattct aaatgaaagg gtgtggtttc catcaatctg atgctgccca   2700

tcgcttgcac tggggtcttt gtggatcggg caggagtttt cagtgtgttg ggtgttgctc   2760

cttcctatgt gtcttttgaa tctgaggctg acatttgctt ggaaggccag acccttgctc   2820

catcagagag ggcagtggca aaggccagtg aggcagctgt gagttggaca gggttcaggt   2880

gagatggtgt tgtcatttgt gcttagtgtt ggtggtgctc agggtggata acacgggtcg   2940

ttctgcagcc cgcttcagca caaataggca gcttaaggcc tggctcacag gctgtggggt   3000

tgatctggct ctgcagaggc cctaggcagc ttgttgactg ctgtctgttg atgacgtgtg   3060

tgcaaagcag gctctagcaa catgatcact gtccttgcct tcctggttct ttctctcggt   3120

tggttgccag ggcttgcaga tcgcagtgaa ttttccttgg ggaacatcgc tgttttgtcc   3180

tagagtgaac ttgtggctta tggccagtgc tgtttggtgg tctgccttct ttttaatggt   3240

attttcttcc tcagagcaga agggctgcat tttgcttatc agaagaaggt gcagatttaa   3300

gg                                                                  3302


<210>  168
<211>  753
<212>  PRT
<213>  Homosapiens

<400>  168

Met Gly Glu His Ser Pro Asp Asn Asn Ile Ile Tyr Phe Glu Ala Glu 
1               5                   10                  15      


Glu Asp Glu Leu Thr Pro Asp Asp Lys Met Leu Arg Phe Val Asp Lys 
            20                  25                  30          


Asn Gly Leu Val Pro Ser Ser Ser Gly Thr Val Tyr Asp Arg Thr Thr 
        35                  40                  45              


Val Leu Ile Glu Gln Asp Pro Gly Thr Leu Glu Asp Glu Asp Asp Asp 
    50                  55                  60                  


Gly Gln Cys Gly Glu His Leu Pro Phe Leu Val Gly Gly Glu Glu Gly 
65                  70                  75                  80  


Phe His Leu Ile Asp His Glu Ala Met Ser Gln Gly Tyr Val Gln His 
                85                  90                  95      


Ile Ile Ser Pro Asp Gln Ile His Leu Thr Ile Asn Pro Gly Ser Thr 
            100                 105                 110         


Pro Met Pro Arg Asn Ile Glu Gly Ala Thr Leu Thr Leu Gln Ser Glu 
        115                 120                 125             


Cys Pro Glu Thr Lys Arg Lys Glu Val Lys Arg Tyr Gln Cys Thr Phe 
    130                 135                 140                 


Glu Gly Cys Pro Arg Thr Tyr Ser Thr Ala Gly Asn Leu Arg Thr His 
145                 150                 155                 160 


Gln Lys Thr His Arg Gly Glu Tyr Thr Phe Val Cys Asn Gln Glu Gly 
                165                 170                 175     


Cys Gly Lys Ala Phe Leu Thr Ser His Ser Leu Arg Ile His Val Arg 
            180                 185                 190         


Val His Thr Lys Glu Lys Pro Phe Glu Cys Asp Val Gln Gly Cys Glu 
        195                 200                 205             


Lys Ala Phe Asn Thr Leu Tyr Arg Leu Lys Ala His Gln Arg Leu His 
    210                 215                 220                 


Thr Gly Lys Thr Phe Asn Cys Glu Ser Glu Gly Cys Ser Lys Tyr Phe 
225                 230                 235                 240 


Thr Thr Leu Ser Asp Leu Arg Lys His Ile Arg Thr His Thr Gly Glu 
                245                 250                 255     


Lys Pro Phe Arg Cys Asp His Asp Gly Cys Gly Lys Ala Phe Ala Ala 
            260                 265                 270         


Ser His His Leu Lys Thr His Val Arg Thr His Thr Gly Glu Arg Pro 
        275                 280                 285             


Phe Phe Cys Pro Ser Asn Gly Cys Glu Lys Thr Phe Ser Thr Gln Tyr 
    290                 295                 300                 


Ser Leu Lys Ser His Met Lys Gly His Asp Asn Lys Gly His Ser Tyr 
305                 310                 315                 320 


Asn Ala Leu Pro Gln His Asn Gly Ser Glu Asp Thr Asn His Ser Leu 
                325                 330                 335     


Cys Leu Ser Asp Leu Ser Leu Leu Ser Thr Asp Ser Glu Leu Arg Glu 
            340                 345                 350         


Asn Ser Ser Thr Thr Gln Gly Gln Asp Leu Ser Thr Ile Ser Pro Ala 
        355                 360                 365             


Ile Ile Phe Glu Ser Met Phe Gln Asn Ser Asp Asp Thr Ala Ile Gln 
    370                 375                 380                 


Glu Asp Pro Gln Gln Thr Ala Ser Leu Thr Glu Ser Phe Asn Gly Asp 
385                 390                 395                 400 


Ala Glu Ser Val Ser Asp Val Pro Pro Ser Thr Gly Asn Ser Ala Ser 
                405                 410                 415     


Leu Ser Leu Pro Leu Val Leu Gln Pro Gly Leu Ser Glu Pro Pro Gln 
            420                 425                 430         


Pro Leu Leu Pro Ala Ser Ala Pro Ser Ala Pro Pro Pro Ala Pro Ser 
        435                 440                 445             


Leu Gly Pro Gly Ser Gln Gln Ala Ala Phe Gly Asn Pro Pro Ala Leu 
    450                 455                 460                 


Leu Gln Pro Pro Glu Val Pro Val Pro His Ser Thr Gln Phe Ala Ala 
465                 470                 475                 480 


Asn His Gln Glu Phe Leu Pro His Pro Gln Ala Pro Gln Pro Ile Val 
                485                 490                 495     


Pro Gly Leu Ser Val Val Ala Gly Ala Ser Ala Ser Ala Ala Ala Val 
            500                 505                 510         


Ala Ser Ala Val Ala Ala Pro Ala Pro Pro Gln Ser Thr Thr Glu Pro 
        515                 520                 525             


Leu Pro Ala Met Val Gln Thr Leu Pro Leu Gly Ala Asn Ser Val Leu 
    530                 535                 540                 


Thr Asn Asn Pro Thr Ile Thr Ile Thr Pro Thr Pro Asn Thr Ala Ile 
545                 550                 555                 560 


Leu Gln Ser Ser Leu Val Met Gly Glu Gln Asn Leu Gln Trp Ile Leu 
                565                 570                 575     


Asn Gly Ala Thr Ser Ser Pro Gln Asn Gln Glu Gln Ile Gln Gln Ala 
            580                 585                 590         


Ser Lys Val Glu Lys Val Phe Phe Thr Thr Ala Val Pro Val Ala Ser 
        595                 600                 605             


Ser Pro Gly Ser Ser Val Gln Gln Ile Gly Leu Ser Val Pro Val Ile 
    610                 615                 620                 


Ile Ile Lys Gln Glu Glu Ala Cys Gln Cys Gln Cys Ala Cys Arg Asp 
625                 630                 635                 640 


Ser Ala Lys Glu Arg Ala Ser Ser Arg Arg Lys Gly Cys Ser Ser Pro 
                645                 650                 655     


Pro Pro Pro Glu Pro Ser Pro Gln Ala Pro Asp Gly Pro Ser Leu Gln 
            660                 665                 670         


Leu Pro Ala Gln Thr Phe Ser Ser Ala Pro Val Pro Gly Ser Ser Ser 
        675                 680                 685             


Ser Thr Leu Pro Ser Ser Cys Glu Gln Ser Arg Gln Ala Glu Thr Pro 
    690                 695                 700                 


Ser Asp Pro Gln Thr Glu Thr Leu Ser Ala Met Asp Val Ser Glu Phe 
705                 710                 715                 720 


Leu Ser Leu Gln Ser Leu Asp Thr Pro Ser Asn Leu Ile Pro Ile Glu 
                725                 730                 735     


Ala Leu Leu Gln Gly Glu Glu Glu Met Gly Leu Thr Ser Ser Phe Ser 
            740                 745                 750         


Lys 
    


<210>  169
<211>  3995
<212>  DNA
<213>  Homosapiens

<400>  169
gtcccgtgcg ccctgtggtg acagctcagg agggtgtgtg cgctcagcag gggccagcat     60

ggaccagtct gtggcaatcc aggagacgct ggctgagggg gaatactgcg tcatcgcggt    120

gcaaggtgtg ctgtgtgagg gggacagccg gcagagccgc ctcctgggac tcgtgcgcta    180

ccgcctggag catggcggcc aggaacacgc tctcttcctc tatacgcacc ggaggatggc    240

cattaccggg gacgatgtct ctctggacca gatagtgcca gtctcgcggg attttacgct    300

ggaagaagtg tccccagatg gtgaactcta catccttggc tcagatgtga ccgtccagct    360

ggacacagca gagcttagcc tcgtattcca actgcccttt ggttcacaaa ccaggatgtt    420

cctccacgaa gttgccaggg cctgtccagg cttcgattct gcgacccggg atcctgaatt    480

cctgtggctg tctcggtata ggtgcgcaga gctggagctg gagatgccaa cgccgcgcgg    540

ttgtaactcg gccctagtta cctggccagg gtacgcgaca attggcggag gtggttctaa    600

ctttgatggt ttgagaccaa atgggaaggg agtgcctatg gaccaaagct ccaggggtca    660

agataaacca gaaagcttgc aaccaagaca gaataaatcc aagtccgaaa ttactgacat    720

ggttcgctcc tccactatca cagtgtcgga caaggctcat attttatcca tgcagaagtt    780

tggactgcga gatacaattg tgaaatcaca tctactacag aaagaagagg attacaccta    840

tatccagaac ttcaggtttt ttgcgggaac atacaatgta aatgggcagt cccccaaaga    900

atgcctccgg ctgtggctga gcaatggtat ccaggcccca gatgtctatt gtgtagggtt    960

ccaggagctt gatctgagta aggaagcttt tttctttcac gataccccaa aggaggaaga   1020

gtggttcaaa gctgtgtcag agggtcttca tccagatgcc aaatatgcaa aggtgaagct   1080

tatccgactg gttgggatta tgctgctgtt atatgtcaaa caggagcatg cagcttatat   1140

ctcagaagtg gaagccgaga ctgtggggac aggaatcatg gggaggatgg gcaacaaggg   1200

aggcgtggcg atcaggttcc agttccacaa caccagcatc tgcgttgtga attctcactt   1260

ggcagcccac attgaagagt atgagaggag gaaccaggac tataaggaca tttgttctcg   1320

aatgcagttt tgtcagcctg acccaagcct tccccctctc accatcagca accatgatgt   1380

gatcttgtgg ctgggggacc tcaactacag gatagaagag ctggatgtgg aaaaagtgaa   1440

aaagctcatc gaagagaagg actttcaaat gctgtatgca tatgatcagc tgaaaattca   1500

ggtggccgca aagactgtct ttgaaggctt cacagagggt gagctcacat tccagcctac   1560

ttacaagtat gatacgggct ctgacgactg ggataccagt gagaagtgcc gtgctcctgc   1620

ctggtgtgat cggattctct ggaaagggaa gaacatcact cagctgagtt accagagcca   1680

catggccctg aagaccagtg accacaagcc tgtcagctca gtgtttgaca tcggggtgag   1740

ggtcgtaaat gacgagcttt accggaagac actggaggaa attgttcgct ccctggataa   1800

gatggaaaat gccaacattc cttctgtgtc cctgtccaag cgagagttct gttttcagaa   1860

tgtgaagtac atgcaattga aagtagaatc ctttacaatt cataatggac aagtaccctg   1920

tcattttgaa ttcatcaaca agcctgatga agagtcttac tgtaagcagt ggctgaatgc   1980

caaccccagc agaggcttcc tcctgccaga ttctgatgtt gagattgact tggagctctt   2040

cgtaaataag acgacagcta caaagctcaa ctcgggtgaa gacaaaattg aggacattct   2100

ggttctgcac ttggacaggg gaaaggatta ctttttgtct gtgtctggga actacctgcc   2160

cagctgtttt gggtctccca ttcatacact gtgttacatg agagagccaa tcttggacct   2220

accacttgaa accattagtg agctgctagc atatttggca gcttattgct tcgaaaccca   2280

gctggtcacc aaaagcttga tatgacagag aagaagaagg ctcaagaatt tattcaccag   2340

ttcctctgca acccactctg agcctatctc tcctcctatt ttacttgagg ctgccaatta   2400

ccagccccac ctgtttcagc tcaagagatg ccttaagata attatgtgag gccacttggt   2460

agcaagaatg gcagctattt cctgagccta gtaccccaat taagcccacc attggttagc   2520

acactcagcg ctgtgagtcg tgaagacacg ggagaaaatc caccataata aaactgacat   2580

tcaattttca actttagtta tttaacacag atttttttat tttttatttt tttttatttt   2640

gagacggagt tttgctctgt cgcgcagggt ggagtgcggt ggcacgatct cggctcactg   2700

caacctctgc ctcctgggtg caagcaatta tcctgcctca gcctcccgag tagctgggac   2760

tacaggcaca cactgccacg cccagctaat tttttgcatt ttagtagaga cggggtttca   2820

ccgtgttgcc caggctgttc taaaactcct gaactcaggt aatctgcctg cctcggcctc   2880

cccaagtgct gggattacag gtgtgagcca ccacgcccgg cctttttttt tttttttttc   2940

ttttttgaga tggagtttca ctctcgttgc ccaggctgga gtgcgttggc gtggtcttgg   3000

ctcactgcaa cctctgcctc cttggttcaa gcgattctcc tgcctcagcc tctcgagtag   3060

ctgggattat aggcgtccgc caccatgcct ggctaatttt tttgtgtgtt tttagtatag   3120

acacggtttc accatgttgg ccaggctggt ctcgaatgcc tggcctcagg tgatccacct   3180

gccttggcct cccaaagtgc tgggattaca ggcatgaacc accacgcctg gcctaaaatg   3240

tttttaaata actgtacttg tactcactca ccctacctcc agggcatagt cagtctgggc   3300

tgagatcccc atgatcagat atttgatgga aagtcctgaa aggccaatga gttggatggc   3360

aagaatgcag gcagaagctg ctggataaaa taggctacag ccacctcaga tgctttcagt   3420

gctctgtctg aggatgtgta tatgcatatg caaactcgac ccccgttcct gcccagataa   3480

tggctcaata actctgaggc tggttgctca gcctctgagg gcaatacagg catttaaaaa   3540

attaaaatga ccaggcacag tggctcacgc ctgtaatctc ggcactttgg gagactgagg   3600

tgggagcatc gcttgagacc aggagtttgg gaccaggctg ggcaacacag ggagaccccc   3660

tctctacaaa aacattttta aaaaattagc tgggcgtggt gatgcatgcc tgtggtccca   3720

gttacttggg aggctgacgt gggtggctca cttgagcaca ggagtttgag gctgcagtga   3780

cctatgacca catcactgta cgccagcccg ggtgagagag ggagaccccg tctctaaaaa   3840

taaaatgtaa aatcactgaa aaaatgagtg ttcggtgaaa caagtgggat tttctgggcc   3900

agcaagtctt ccaaactgta tatgatgcat cctgtctcca tgtgtaatat attttaatga   3960

taaatgtatt tttaacagtg aaaaaaaaaa aaaaa                              3995


<210>  170
<211>  748
<212>  PRT
<213>  Homosapiens

<400>  170

Met Asp Gln Ser Val Ala Ile Gln Glu Thr Leu Ala Glu Gly Glu Tyr 
1               5                   10                  15      


Cys Val Ile Ala Val Gln Gly Val Leu Cys Glu Gly Asp Ser Arg Gln 
            20                  25                  30          


Ser Arg Leu Leu Gly Leu Val Arg Tyr Arg Leu Glu His Gly Gly Gln 
        35                  40                  45              


Glu His Ala Leu Phe Leu Tyr Thr His Arg Arg Met Ala Ile Thr Gly 
    50                  55                  60                  


Asp Asp Val Ser Leu Asp Gln Ile Val Pro Val Ser Arg Asp Phe Thr 
65                  70                  75                  80  


Leu Glu Glu Val Ser Pro Asp Gly Glu Leu Tyr Ile Leu Gly Ser Asp 
                85                  90                  95      


Val Thr Val Gln Leu Asp Thr Ala Glu Leu Ser Leu Val Phe Gln Leu 
            100                 105                 110         


Pro Phe Gly Ser Gln Thr Arg Met Phe Leu His Glu Val Ala Arg Ala 
        115                 120                 125             


Cys Pro Gly Phe Asp Ser Ala Thr Arg Asp Pro Glu Phe Leu Trp Leu 
    130                 135                 140                 


Ser Arg Tyr Arg Cys Ala Glu Leu Glu Leu Glu Met Pro Thr Pro Arg 
145                 150                 155                 160 


Gly Cys Asn Ser Ala Leu Val Thr Trp Pro Gly Tyr Ala Thr Ile Gly 
                165                 170                 175     


Gly Gly Gly Ser Asn Phe Asp Gly Leu Arg Pro Asn Gly Lys Gly Val 
            180                 185                 190         


Pro Met Asp Gln Ser Ser Arg Gly Gln Asp Lys Pro Glu Ser Leu Gln 
        195                 200                 205             


Pro Arg Gln Asn Lys Ser Lys Ser Glu Ile Thr Asp Met Val Arg Ser 
    210                 215                 220                 


Ser Thr Ile Thr Val Ser Asp Lys Ala His Ile Leu Ser Met Gln Lys 
225                 230                 235                 240 


Phe Gly Leu Arg Asp Thr Ile Val Lys Ser His Leu Leu Gln Lys Glu 
                245                 250                 255     


Glu Asp Tyr Thr Tyr Ile Gln Asn Phe Arg Phe Phe Ala Gly Thr Tyr 
            260                 265                 270         


Asn Val Asn Gly Gln Ser Pro Lys Glu Cys Leu Arg Leu Trp Leu Ser 
        275                 280                 285             


Asn Gly Ile Gln Ala Pro Asp Val Tyr Cys Val Gly Phe Gln Glu Leu 
    290                 295                 300                 


Asp Leu Ser Lys Glu Ala Phe Phe Phe His Asp Thr Pro Lys Glu Glu 
305                 310                 315                 320 


Glu Trp Phe Lys Ala Val Ser Glu Gly Leu His Pro Asp Ala Lys Tyr 
                325                 330                 335     


Ala Lys Val Lys Leu Ile Arg Leu Val Gly Ile Met Leu Leu Leu Tyr 
            340                 345                 350         


Val Lys Gln Glu His Ala Ala Tyr Ile Ser Glu Val Glu Ala Glu Thr 
        355                 360                 365             


Val Gly Thr Gly Ile Met Gly Arg Met Gly Asn Lys Gly Gly Val Ala 
    370                 375                 380                 


Ile Arg Phe Gln Phe His Asn Thr Ser Ile Cys Val Val Asn Ser His 
385                 390                 395                 400 


Leu Ala Ala His Ile Glu Glu Tyr Glu Arg Arg Asn Gln Asp Tyr Lys 
                405                 410                 415     


Asp Ile Cys Ser Arg Met Gln Phe Cys Gln Pro Asp Pro Ser Leu Pro 
            420                 425                 430         


Pro Leu Thr Ile Ser Asn His Asp Val Ile Leu Trp Leu Gly Asp Leu 
        435                 440                 445             


Asn Tyr Arg Ile Glu Glu Leu Asp Val Glu Lys Val Lys Lys Leu Ile 
    450                 455                 460                 


Glu Glu Lys Asp Phe Gln Met Leu Tyr Ala Tyr Asp Gln Leu Lys Ile 
465                 470                 475                 480 


Gln Val Ala Ala Lys Thr Val Phe Glu Gly Phe Thr Glu Gly Glu Leu 
                485                 490                 495     


Thr Phe Gln Pro Thr Tyr Lys Tyr Asp Thr Gly Ser Asp Asp Trp Asp 
            500                 505                 510         


Thr Ser Glu Lys Cys Arg Ala Pro Ala Trp Cys Asp Arg Ile Leu Trp 
        515                 520                 525             


Lys Gly Lys Asn Ile Thr Gln Leu Ser Tyr Gln Ser His Met Ala Leu 
    530                 535                 540                 


Lys Thr Ser Asp His Lys Pro Val Ser Ser Val Phe Asp Ile Gly Val 
545                 550                 555                 560 


Arg Val Val Asn Asp Glu Leu Tyr Arg Lys Thr Leu Glu Glu Ile Val 
                565                 570                 575     


Arg Ser Leu Asp Lys Met Glu Asn Ala Asn Ile Pro Ser Val Ser Leu 
            580                 585                 590         


Ser Lys Arg Glu Phe Cys Phe Gln Asn Val Lys Tyr Met Gln Leu Lys 
        595                 600                 605             


Val Glu Ser Phe Thr Ile His Asn Gly Gln Val Pro Cys His Phe Glu 
    610                 615                 620                 


Phe Ile Asn Lys Pro Asp Glu Glu Ser Tyr Cys Lys Gln Trp Leu Asn 
625                 630                 635                 640 


Ala Asn Pro Ser Arg Gly Phe Leu Leu Pro Asp Ser Asp Val Glu Ile 
                645                 650                 655     


Asp Leu Glu Leu Phe Val Asn Lys Thr Thr Ala Thr Lys Leu Asn Ser 
            660                 665                 670         


Gly Glu Asp Lys Ile Glu Asp Ile Leu Val Leu His Leu Asp Arg Gly 
        675                 680                 685             


Lys Asp Tyr Phe Leu Ser Val Ser Gly Asn Tyr Leu Pro Ser Cys Phe 
    690                 695                 700                 


Gly Ser Pro Ile His Thr Leu Cys Tyr Met Arg Glu Pro Ile Leu Asp 
705                 710                 715                 720 


Leu Pro Leu Glu Thr Ile Ser Glu Leu Leu Ala Tyr Leu Ala Ala Tyr 
                725                 730                 735     


Cys Phe Glu Thr Gln Leu Val Thr Lys Ser Leu Ile 
            740                 745             


<210>  171
<211>  2855
<212>  DNA
<213>  Homosapiens

<400>  171
ttccggcact cgcggaactt tggtgcagcc tgatgcgcaa cgtggggact caggcgcgct     60

gggcggcagg agttgcttcc ggccgtgttg gtggtctgaa ttgagaagcc gcgactaagg    120

gaagatggag acaatactgg agcagcagcg gcgctatcat gaggagaagg aacggctcat    180

ggacgtcatg gctaaagaga tgctcaccaa gaagtccacg ctccgggacc agatcaattc    240

tgatcaccgc actcgggcca tgcaagatag gtatatggag gtcagtggga acctgaggga    300

tttgtatgat gataaggatg gattacgaaa ggaggagctc aatgccattt caggacccaa    360

tgagtttgct gaattctata atagactcaa gcaaataaag gaattccacc ggaagcaccc    420

aaatgagatc tgtgtgccaa tgtcagtgga atttgaggaa ctcctgaagg ctcgagagaa    480

tccaagtgaa gaggcacaaa acttggtgga gttcacagat gaagagggat atggtcgtta    540

tctcgatctc catgactgtt acctcaagta cattaacctg aaggcatctg agaagctgga    600

ttatatcaca tacctgtcca tctttgacca attatttgac attcctaaag aaaggaagaa    660

tgcagagtat aagagatacc tagagatgct gcttgagtac cttcaggatt acacagatag    720

agtgaagcct ctccaagatc agaatgaact ttttgggaag attcaggctg agtttgagaa    780

gaaatgggag aatgggacct ttcctggatg gccgaaagag acaagcagtg ccctgaccca    840

tgctggagcc catcttgacc tctctgcatt ctcctcctgg gaggagttgg cttctctggg    900

tttggacaga ttgaaatctg ctctcttagc tttaggcttg aaatgtggcg ggaccctaga    960

agagcgagcc cagagactat tcagtaccaa aggaaagtcc ctggagtcac ttgatacctc   1020

tttgtttgcc aaaaatccca agtcaaaggg caccaagcga gacactgaaa ggaacaaaga   1080

cattgctttt ctagaagccc agatctatga atatgtagag attctcgggg aacagcgaca   1140

tctcactcat gaaaatgtac agcgcaagca agccaggaca ggagaagagc gagaagaaga   1200

ggaagaagag cagatcagtg agagtgagag tgaagatgaa gagaacgaga tcatttacaa   1260

ccccaaaaac ctgccacttg gctgggatgg caaacctatt ccctactggc tgtataagct   1320

tcatggccta aatatcaact acaactgtga gatttgtgga aactacacct accgagggcc   1380

caaagccttc cagcgacact ttgctgaatg gcgtcatgct catggcatga ggtgtttggg   1440

catcccaaac actgctcact ttgctaatgt gacacagatt gaagatgctg tctccttgtg   1500

ggccaaactg aaattgcaga aggcttcaga acgatggcag cctgacactg aggaagaata   1560

tgaagactca agtgggaatg ttgtgaataa gaagacatac gaggatctga aaagacaagg   1620

actgctctag tgttcaggga tgtagctcag cttttgggct agcccaggct tccctaagat   1680

ctgctttttc tatttctccc aaccaaatcc tcttaaagac cctttgctat gtagtctcat   1740

ggtctagcat gcatcttgta gaaacaaggc atgctggcag attgcagggt tgagatgtgt   1800

tttatctgtt ttatatttta aaagattctg ccagaaaata aaaccagacc ttgttctaaa   1860

gcccagggtt atggaccaac tcagtgcttc aggtcttaac gcctccatac ctcttcctca   1920

ccaactttac tagtagctga gatttaatgg gcacctatta tgctacatat catgttaggt   1980

aaatctgacc tgacctcttt ccccaccctc ctttgttgct gcttccctga atgagtatta   2040

ccccaggatg aggtctgcca tcagcttagt tagccattga tgcaaatact agggaaagac   2100

taggaggatg agccagggtt gctactaagg actaagtgtc gcaccaaggt ttgccttttg   2160

tatttgcata aagaaaggag ttggagctgg gtgcagtggc ttgtgcctgt agtcccagct   2220

acttgggagg ctgaggcagg agggttgctt gagactagcc taggtaacat agtgagaccc   2280

tgtctcatta aaaaaaaaaa aaaggcatgg tggcacgcac tgtagtccca gctactcagg   2340

agactgaggc tagaagatcc tttgaaccta ggagtttgag accagcctgg gcgatatagt   2400

gaggccccat ctcaaaaaaa aaaaaagggg gggggggggg agttgggctg tgttggaatg   2460

ggcctgcagc ccaacaaaca agggaactag gaccgacagt gacttcacca gcttgctagg   2520

tcagaatgag agactggtgg gtctgtctac ctgtttcttc tacaagatcc ctatttgact   2580

gtaaaagtag ctaatactca catgttctcc aatcccaggt agccatggta gagttgggta   2640

gagttgagca gctgccccag gatccaaatg tggtgtctga aatggaaaga actaaggcaa   2700

ccaggaaggc actgatctgc cttataagca cagtcatctg aaagtcaggc ctgctgcagg   2760

acaggatccc ccagagaccc catttgcctc tcaacactca gaccttcaac tgttttttaa   2820

taaatctact ttttaaaaaa aaaaaaaaaa aaaaa                              2855


<210>  172
<211>  501
<212>  PRT
<213>  Homosapiens

<400>  172

Met Glu Thr Ile Leu Glu Gln Gln Arg Arg Tyr His Glu Glu Lys Glu 
1               5                   10                  15      


Arg Leu Met Asp Val Met Ala Lys Glu Met Leu Thr Lys Lys Ser Thr 
            20                  25                  30          


Leu Arg Asp Gln Ile Asn Ser Asp His Arg Thr Arg Ala Met Gln Asp 
        35                  40                  45              


Arg Tyr Met Glu Val Ser Gly Asn Leu Arg Asp Leu Tyr Asp Asp Lys 
    50                  55                  60                  


Asp Gly Leu Arg Lys Glu Glu Leu Asn Ala Ile Ser Gly Pro Asn Glu 
65                  70                  75                  80  


Phe Ala Glu Phe Tyr Asn Arg Leu Lys Gln Ile Lys Glu Phe His Arg 
                85                  90                  95      


Lys His Pro Asn Glu Ile Cys Val Pro Met Ser Val Glu Phe Glu Glu 
            100                 105                 110         


Leu Leu Lys Ala Arg Glu Asn Pro Ser Glu Glu Ala Gln Asn Leu Val 
        115                 120                 125             


Glu Phe Thr Asp Glu Glu Gly Tyr Gly Arg Tyr Leu Asp Leu His Asp 
    130                 135                 140                 


Cys Tyr Leu Lys Tyr Ile Asn Leu Lys Ala Ser Glu Lys Leu Asp Tyr 
145                 150                 155                 160 


Ile Thr Tyr Leu Ser Ile Phe Asp Gln Leu Phe Asp Ile Pro Lys Glu 
                165                 170                 175     


Arg Lys Asn Ala Glu Tyr Lys Arg Tyr Leu Glu Met Leu Leu Glu Tyr 
            180                 185                 190         


Leu Gln Asp Tyr Thr Asp Arg Val Lys Pro Leu Gln Asp Gln Asn Glu 
        195                 200                 205             


Leu Phe Gly Lys Ile Gln Ala Glu Phe Glu Lys Lys Trp Glu Asn Gly 
    210                 215                 220                 


Thr Phe Pro Gly Trp Pro Lys Glu Thr Ser Ser Ala Leu Thr His Ala 
225                 230                 235                 240 


Gly Ala His Leu Asp Leu Ser Ala Phe Ser Ser Trp Glu Glu Leu Ala 
                245                 250                 255     


Ser Leu Gly Leu Asp Arg Leu Lys Ser Ala Leu Leu Ala Leu Gly Leu 
            260                 265                 270         


Lys Cys Gly Gly Thr Leu Glu Glu Arg Ala Gln Arg Leu Phe Ser Thr 
        275                 280                 285             


Lys Gly Lys Ser Leu Glu Ser Leu Asp Thr Ser Leu Phe Ala Lys Asn 
    290                 295                 300                 


Pro Lys Ser Lys Gly Thr Lys Arg Asp Thr Glu Arg Asn Lys Asp Ile 
305                 310                 315                 320 


Ala Phe Leu Glu Ala Gln Ile Tyr Glu Tyr Val Glu Ile Leu Gly Glu 
                325                 330                 335     


Gln Arg His Leu Thr His Glu Asn Val Gln Arg Lys Gln Ala Arg Thr 
            340                 345                 350         


Gly Glu Glu Arg Glu Glu Glu Glu Glu Glu Gln Ile Ser Glu Ser Glu 
        355                 360                 365             


Ser Glu Asp Glu Glu Asn Glu Ile Ile Tyr Asn Pro Lys Asn Leu Pro 
    370                 375                 380                 


Leu Gly Trp Asp Gly Lys Pro Ile Pro Tyr Trp Leu Tyr Lys Leu His 
385                 390                 395                 400 


Gly Leu Asn Ile Asn Tyr Asn Cys Glu Ile Cys Gly Asn Tyr Thr Tyr 
                405                 410                 415     


Arg Gly Pro Lys Ala Phe Gln Arg His Phe Ala Glu Trp Arg His Ala 
            420                 425                 430         


His Gly Met Arg Cys Leu Gly Ile Pro Asn Thr Ala His Phe Ala Asn 
        435                 440                 445             


Val Thr Gln Ile Glu Asp Ala Val Ser Leu Trp Ala Lys Leu Lys Leu 
    450                 455                 460                 


Gln Lys Ala Ser Glu Arg Trp Gln Pro Asp Thr Glu Glu Glu Tyr Glu 
465                 470                 475                 480 


Asp Ser Ser Gly Asn Val Val Asn Lys Lys Thr Tyr Glu Asp Leu Lys 
                485                 490                 495     


Arg Gln Gly Leu Leu 
            500     


<210>  173
<211>  1738
<212>  DNA
<213>  Homosapiens

<400>  173
ggcgggcccg cgctcacttc ctcggggagg ggttggggcc gcgctcccac tcgcccacac     60

ggtccgtctg cagtcggcag cctcgccggc agctcgctcg gcccccgctt ggcccggccc    120

gcaggtagga gccgccgagg gacgcggcgc ccggttcccg gccccgcctg cgccgcgcgc    180

tccccgctcc cgccgcccgc ttcgagggtt ctctcccctt gccaccatga gcgagtcatt    240

tgactgtgca aaatgcaacg agtccctgta tggacgcaag tacatccaga cagacagcgg    300

cccctactgt gtgccctgct atgacaatac ctttgccaac acctgtgctg agtgccagca    360

gcttatcggg catgactcga gggagctgtt ctatgaagac cgccatttcc acgagggctg    420

cttccgctgc tgccgctgcc agcgctcact agccgatgaa cccttcacct gccaggacag    480

tgagctgctc tgcaatgact gctactgcag tgcgttttcc tcgcagtgct ccgcttgtgg    540

ggagactgtc atgcctgggt cccggaagct ggaatatgga ggccagacat ggcatgagca    600

ctgcttcctg tgcagtggct gtgaacagcc actgggctcc cgttcttttg tgcccgacaa    660

gggtgctcac tactgcgtgc cctgctatga gaacaagttt gctcctcgct gcgcccgctg    720

cagcaagacg ctgacacagg gtggagtgac ataccgtgat cagccgtggc atcgagaatg    780

tctggtctgt accggatgcc agacgcccct ggcagggcag cagttcacct cccgggatga    840

agatccctac tgtgtggcct gttttggaga actctttgca cctaagtgca gcagctgcaa    900

gcgccccatc gtaggactcg gtggaggcaa gtatgtgtcc tttgaagacc gacactggca    960

ccacaactgc ttctcctgcg cccgctgctc tacctccctg gtgggccagg gcttcgtacc   1020

ggatggagac caagtgctct gccagggctg tagccaggca gggccctaag ccagggctcc   1080

tggacccagg ctttcccata ccacgggccc aggactgtgg ctccttttct aaaccacctc   1140

tgggactcag ctccccccgc caaaaaaaat gggtctcctt ctgggctcca ggattgtctc   1200

cccactccag catccccaaa ctggtactcc ctgacccagg cccccaatcc tgggctctta   1260

cagagcctcc atgagtcaag ccccctcccc acacctggac tccagaattc accctctccc   1320

ctgcagtctg ggttcccaga ctgagtcctc tccccaaatc agggctctag acccgagccc   1380

tccaaacctg gactctggga cttaggcccc cttaaatcta gacttctctt tataggtttc   1440

aggtctccta tgggtgcctg ggaagtcctt gaaagtggac tgttctcagg cttgacctgc   1500

cccaccccat ccccgcggtt gaggctgtgg gggcagcaga tcaggagccc actgataagg   1560

ggccctaggg tacagggtgc tgcccagcag gtcgccaccg agtgtcttct cattttattt   1620

cagctccatt ttgcccatag atgggcagag gggtgagatt ggctcatccc ccttccagat   1680

tctgcaataa agcggtgtga ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa     1738


<210>  174
<211>  280
<212>  PRT
<213>  Homosapiens

<400>  174

Met Ser Glu Ser Phe Asp Cys Ala Lys Cys Asn Glu Ser Leu Tyr Gly 
1               5                   10                  15      


Arg Lys Tyr Ile Gln Thr Asp Ser Gly Pro Tyr Cys Val Pro Cys Tyr 
            20                  25                  30          


Asp Asn Thr Phe Ala Asn Thr Cys Ala Glu Cys Gln Gln Leu Ile Gly 
        35                  40                  45              


His Asp Ser Arg Glu Leu Phe Tyr Glu Asp Arg His Phe His Glu Gly 
    50                  55                  60                  


Cys Phe Arg Cys Cys Arg Cys Gln Arg Ser Leu Ala Asp Glu Pro Phe 
65                  70                  75                  80  


Thr Cys Gln Asp Ser Glu Leu Leu Cys Asn Asp Cys Tyr Cys Ser Ala 
                85                  90                  95      


Phe Ser Ser Gln Cys Ser Ala Cys Gly Glu Thr Val Met Pro Gly Ser 
            100                 105                 110         


Arg Lys Leu Glu Tyr Gly Gly Gln Thr Trp His Glu His Cys Phe Leu 
        115                 120                 125             


Cys Ser Gly Cys Glu Gln Pro Leu Gly Ser Arg Ser Phe Val Pro Asp 
    130                 135                 140                 


Lys Gly Ala His Tyr Cys Val Pro Cys Tyr Glu Asn Lys Phe Ala Pro 
145                 150                 155                 160 


Arg Cys Ala Arg Cys Ser Lys Thr Leu Thr Gln Gly Gly Val Thr Tyr 
                165                 170                 175     


Arg Asp Gln Pro Trp His Arg Glu Cys Leu Val Cys Thr Gly Cys Gln 
            180                 185                 190         


Thr Pro Leu Ala Gly Gln Gln Phe Thr Ser Arg Asp Glu Asp Pro Tyr 
        195                 200                 205             


Cys Val Ala Cys Phe Gly Glu Leu Phe Ala Pro Lys Cys Ser Ser Cys 
    210                 215                 220                 


Lys Arg Pro Ile Val Gly Leu Gly Gly Gly Lys Tyr Val Ser Phe Glu 
225                 230                 235                 240 


Asp Arg His Trp His His Asn Cys Phe Ser Cys Ala Arg Cys Ser Thr 
                245                 250                 255     


Ser Leu Val Gly Gln Gly Phe Val Pro Asp Gly Asp Gln Val Leu Cys 
            260                 265                 270         


Gln Gly Cys Ser Gln Ala Gly Pro 
        275                 280 


<210>  175
<211>  1017
<212>  DNA
<213>  Homosapiens

<400>  175
tggcggcaga ggcagtgcgg atccggcgtt ctccactgat cttttccaag gctgtacaga     60

catggcggcg gcttttcgga aggcggctaa gtcccggcag cgggaacaca gagagcgaag    120

cgagcctggc tttcgaaaac atctgggcct gctggagaaa aagaaagatt acaaacttcg    180

tgcagatgac taccgtaaaa aacaagaata cctcaaagct cttcggaaga aggctcttga    240

aaaaaatcca gatgaattct actacaaaat gactcgggtt aaactccagg atggagtaca    300

tattattaag gagactaagg aagaagtaac cccagaacaa ctaaagctga tgagaactca    360

ggacgtcaaa tatatagaaa tgaagagggt tgcagaagct aagaaaatcg aaagactaaa    420

atcagagctc catctgctgg atttccaggg gaagcaacag aacaagcatg tgttcttttt    480

tgacaccaaa aaggaagttg aacagtttga tgtcgcaact cacctgcaaa cagccccgga    540

gctagtcgac agagtcttta ataggcccag gatagagacc ttgcagaaag aaaaagtgaa    600

aggagttacc aatcagactg gacttaagcg aatagctaaa gaaaggcaaa agcagtataa    660

ctgcctgaca cagcggattg aacgagagaa gaaattgttc gttattgctc agaaaattca    720

aacacgcaaa gatcttatgg ataaaactca gaaagtgaag gtgaagaaag aaacggtgaa    780

ctccccagct atttataaat ttcagagtcg tcgaaaacgt tgacgtgtta tagataagcc    840

ttgtcattct gtatcaaaaa tctgttgtcg ttttctagta acttcaaatt ccattactcc    900

aaatggcatg gttttccggt ttgtaaccat aactaaattg tcagtctgac atttaatgtc    960

tttctatgga caacattaaa tctccctccc ttctgtaatt gtttttggat tgtgaaa      1017


<210>  176
<211>  253
<212>  PRT
<213>  Homosapiens

<400>  176

Met Ala Ala Ala Phe Arg Lys Ala Ala Lys Ser Arg Gln Arg Glu His 
1               5                   10                  15      


Arg Glu Arg Ser Glu Pro Gly Phe Arg Lys His Leu Gly Leu Leu Glu 
            20                  25                  30          


Lys Lys Lys Asp Tyr Lys Leu Arg Ala Asp Asp Tyr Arg Lys Lys Gln 
        35                  40                  45              


Glu Tyr Leu Lys Ala Leu Arg Lys Lys Ala Leu Glu Lys Asn Pro Asp 
    50                  55                  60                  


Glu Phe Tyr Tyr Lys Met Thr Arg Val Lys Leu Gln Asp Gly Val His 
65                  70                  75                  80  


Ile Ile Lys Glu Thr Lys Glu Glu Val Thr Pro Glu Gln Leu Lys Leu 
                85                  90                  95      


Met Arg Thr Gln Asp Val Lys Tyr Ile Glu Met Lys Arg Val Ala Glu 
            100                 105                 110         


Ala Lys Lys Ile Glu Arg Leu Lys Ser Glu Leu His Leu Leu Asp Phe 
        115                 120                 125             


Gln Gly Lys Gln Gln Asn Lys His Val Phe Phe Phe Asp Thr Lys Lys 
    130                 135                 140                 


Glu Val Glu Gln Phe Asp Val Ala Thr His Leu Gln Thr Ala Pro Glu 
145                 150                 155                 160 


Leu Val Asp Arg Val Phe Asn Arg Pro Arg Ile Glu Thr Leu Gln Lys 
                165                 170                 175     


Glu Lys Val Lys Gly Val Thr Asn Gln Thr Gly Leu Lys Arg Ile Ala 
            180                 185                 190         


Lys Glu Arg Gln Lys Gln Tyr Asn Cys Leu Thr Gln Arg Ile Glu Arg 
        195                 200                 205             


Glu Lys Lys Leu Phe Val Ile Ala Gln Lys Ile Gln Thr Arg Lys Asp 
    210                 215                 220                 


Leu Met Asp Lys Thr Gln Lys Val Lys Val Lys Lys Glu Thr Val Asn 
225                 230                 235                 240 


Ser Pro Ala Ile Tyr Lys Phe Gln Ser Arg Arg Lys Arg 
                245                 250             


<210>  177
<211>  1442
<212>  DNA
<213>  Homosapiens

<400>  177
gggcggcggc ggctccagca ccatgtccct gcagtacggg gcggaggaga cgcccctcgc     60

cggcagttac ggcgcggccg attcgtttcc aaaggacttc ggctacggcg tggaggagga    120

ggaagaggag gcggcggcgg cgggcggagg ggttggggca ggggcaggcg gtggctgtgg    180

tccggggggc gctgacagct ccaagccgag gattctgctc atgggactcc ggcgcagcgg    240

caagtcctcc atccagaagg tggtgtttca taagatgtca cccaacgaga ccctcttttt    300

ggaaagtacc aacaagattt ataaggatga catttccaat agctcctttg tgaatttcca    360

gatatgggat tttcctgggc aaatggactt ttttgaccca acctttgact atgagatgat    420

cttcagggga acaggagcat tgatatacgt cattgacgca caggatgact acatggaggc    480

tttaacaaga cttcacatta ctgtttctaa agcctacaaa gttaacccag acatgaattt    540

tgaggttttt attcacaaag ttgatggtct gtctgatgat cacaaaatag aaacacagag    600

ggacattcat caaagggcca atgatgacct tgcagatgct gggctagaaa aactccatct    660

tagcttttat ctgactagta tctatgacca ttcaatattt gaagccttta gtaaggtggt    720

gcagaaactc attccacaac tgccgacctt ggaaaaccta ttaaatatct ttatatcaaa    780

ttcaggtatt gaaaaagctt ttctctttga tgttgtcagc aaaatctaca ttgcaacaga    840

cagttcccct gtggatatgc aatcttatga actttgctgt gacatgatcg atgttgtaat    900

tgatgtgtct tgtatatatg ggttaaagga agatggaagt ggaagtgctt atgacaaaga    960

atctatggca attatcaagc tgaataatac aactgtcctt tatttaaagg aggtgactaa   1020

atttttggca ctggtctgca ttctaaggga agaaagcttt gaaagaaaag gtttaataga   1080

ctacaacttc cactgtttcc gaaaagctat tcatgaggtt tttgaggtgg gtgtgacttc   1140

tcacaggagc tgtggtcacc agactagtgc ctccagtctg aaagcgctga cacacaatgg   1200

cacgccacga aacgccatct agtctgaatc ccagcgtcgg ggctctgtgc cagcttactc   1260

ttcactccag ggtcggatgc cacgtgctac aggacatggg agctgctgct tgtgggaatc   1320

tggtgcctgt tccactagag acaaggggta gagtttctca tttggatgaa aaccccttca   1380

actggtggtg tacaactgaa gctactatat cttttttgaa aatggcaaaa aaaaaaaaaa   1440

aa                                                                  1442


<210>  178
<211>  399
<212>  PRT
<213>  Homosapiens

<400>  178

Met Ser Leu Gln Tyr Gly Ala Glu Glu Thr Pro Leu Ala Gly Ser Tyr 
1               5                   10                  15      


Gly Ala Ala Asp Ser Phe Pro Lys Asp Phe Gly Tyr Gly Val Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Ala Ala Ala Ala Gly Gly Gly Val Gly Ala Gly Ala 
        35                  40                  45              


Gly Gly Gly Cys Gly Pro Gly Gly Ala Asp Ser Ser Lys Pro Arg Ile 
    50                  55                  60                  


Leu Leu Met Gly Leu Arg Arg Ser Gly Lys Ser Ser Ile Gln Lys Val 
65                  70                  75                  80  


Val Phe His Lys Met Ser Pro Asn Glu Thr Leu Phe Leu Glu Ser Thr 
                85                  90                  95      


Asn Lys Ile Tyr Lys Asp Asp Ile Ser Asn Ser Ser Phe Val Asn Phe 
            100                 105                 110         


Gln Ile Trp Asp Phe Pro Gly Gln Met Asp Phe Phe Asp Pro Thr Phe 
        115                 120                 125             


Asp Tyr Glu Met Ile Phe Arg Gly Thr Gly Ala Leu Ile Tyr Val Ile 
    130                 135                 140                 


Asp Ala Gln Asp Asp Tyr Met Glu Ala Leu Thr Arg Leu His Ile Thr 
145                 150                 155                 160 


Val Ser Lys Ala Tyr Lys Val Asn Pro Asp Met Asn Phe Glu Val Phe 
                165                 170                 175     


Ile His Lys Val Asp Gly Leu Ser Asp Asp His Lys Ile Glu Thr Gln 
            180                 185                 190         


Arg Asp Ile His Gln Arg Ala Asn Asp Asp Leu Ala Asp Ala Gly Leu 
        195                 200                 205             


Glu Lys Leu His Leu Ser Phe Tyr Leu Thr Ser Ile Tyr Asp His Ser 
    210                 215                 220                 


Ile Phe Glu Ala Phe Ser Lys Val Val Gln Lys Leu Ile Pro Gln Leu 
225                 230                 235                 240 


Pro Thr Leu Glu Asn Leu Leu Asn Ile Phe Ile Ser Asn Ser Gly Ile 
                245                 250                 255     


Glu Lys Ala Phe Leu Phe Asp Val Val Ser Lys Ile Tyr Ile Ala Thr 
            260                 265                 270         


Asp Ser Ser Pro Val Asp Met Gln Ser Tyr Glu Leu Cys Cys Asp Met 
        275                 280                 285             


Ile Asp Val Val Ile Asp Val Ser Cys Ile Tyr Gly Leu Lys Glu Asp 
    290                 295                 300                 


Gly Ser Gly Ser Ala Tyr Asp Lys Glu Ser Met Ala Ile Ile Lys Leu 
305                 310                 315                 320 


Asn Asn Thr Thr Val Leu Tyr Leu Lys Glu Val Thr Lys Phe Leu Ala 
                325                 330                 335     


Leu Val Cys Ile Leu Arg Glu Glu Ser Phe Glu Arg Lys Gly Leu Ile 
            340                 345                 350         


Asp Tyr Asn Phe His Cys Phe Arg Lys Ala Ile His Glu Val Phe Glu 
        355                 360                 365             


Val Gly Val Thr Ser His Arg Ser Cys Gly His Gln Thr Ser Ala Ser 
    370                 375                 380                 


Ser Leu Lys Ala Leu Thr His Asn Gly Thr Pro Arg Asn Ala Ile 
385                 390                 395                 


<210>  179
<211>  2093
<212>  DNA
<213>  Homosapiens

<400>  179
gcgcatgagc agtgctgctc ccaacccgcc agtcgcggtc tccggcgcca gctacgccgc     60

tgccgctgtc actatggccc attacaaagc cgccgactcg aagcgtgagc agttccggag    120

gtacttggag aagtcggggg tgctggacac gctgaccaag gtgttggtag ccttatatga    180

agaaccagag aaacctaaca gtgctttgga ttttttaaag catcacttag gagctgctac    240

tccagaaaat ccagaaatag agctgcttcg cctagaactg gccgaaatga aagagaagta    300

tgaagctatt gtagaagaaa ataaaaaact gaaagcaaag cttgctcagt atgaaccacc    360

tcaggaggag aagcgtgctg aataggattc ttctcagttt gaaagacaat gaaaaatggt    420

tttgtatgac ttgaatagtt tgtatagtat ataatctttt ctgaacagat gctatagaac    480

tcttttaata tgtttaattc acctatcaca ctctgttaaa aacacataga atcatcaata    540

aaaactcaat ataactttct ttgggtctta aagcaggaga atccaaagta aatcctgaac    600

aaaacctaaa cacagccatc taactcatta ccttaaaaga cattctgttt attagtctga    660

ttaggaatga tggcactggt tgtattttag ccaagacagt ttagcatgga gctattcctt    720

ggtgcagttc aggatatgaa cacaggtaca gtcattcttt gaaggtgaca ctgttctgta    780

tattccctat aggcagctgg agagatctgt gtgacacaag atgcttttgt acgggttccc    840

atgaatcttc tgctcttgtt tgtgtgacat ggaacaaata acttctttgc caccactttg    900

ccttagataa ctgtgtgtgt gtgtgccagt ttgaactctg acaccacatt ttccttctat    960

gcaatcatgc ctgtctgata atcttgcatt gctttcctct gagctttagt gggtcctagt   1020

tgcacactgg cctttctgtg ctgtttttca atttgcctaa taatagcagt taccctgatt   1080

gtaatttatg taactttaaa caggatcaca ctgtaccccc tgcctgcctt atttgcttac   1140

tgagcacagg acagaggcaa tatacaactc tgggttcaca cacaagctga gatgagaaga   1200

ggaatgagcc atatattggg gaaaatcata gtttgtaggt ataattatat agtgcttttc   1260

tccctcaaag tatttttcta gccttgaatt cattttatct tcattatccc tgtgaagtag   1320

gtgggacaag tataagggga agaggggtgc tgaattttta ggccaaagac tgatattaat   1380

acaaatcact cactaactgt agagccttgg gcattatcag tgaactactc tgagatttac   1440

tgtcttcatc tgtttaatga gtagaatgtc cgtgatgcct acctcacagg gttgttgtga   1500

gggtcaaatg agaatgtatg tgaaagattt gtaaatggta aagcactata ttcttgtttg   1560

ttagtccttt ttcctttctt tgggtagacc tacagtcaga tgttttgttt tatggatcac   1620

ttattttcct tactggtaga ctgtcgtttt atagacatat tcctatttca tatattctct   1680

ccctgttgtt agagaaccta tctttgtttt tggtcaaaac acacatagaa aacaaaatga   1740

tccaatgaaa actggtttaa ctagcaaaag ccttggcacc tgttggagac tatgaccaag   1800

ccaataaaaa gggcatttaa atcagccctg ttagtaggaa tgtggctatg gctggtgcct   1860

cttctagtca caagtttgtt tttggagggg gtccagaaga tcattccctt gcatagattt   1920

ctcttttacc aatttgagtg cctcctacat gggcagcagt ggactaagtg ctgggtgtga   1980

taaagaggaa tgacttaatt atgagactgt atataatcaa atacagtgtg ggttaggacc   2040

tgtggcagac cattataata aagcatggcc ccgtgagggt tttgaaagag aaa          2093


<210>  180
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  180

Met Ala His Tyr Lys Ala Ala Asp Ser Lys Arg Glu Gln Phe Arg Arg 
1               5                   10                  15      


Tyr Leu Glu Lys Ser Gly Val Leu Asp Thr Leu Thr Lys Val Leu Val 
            20                  25                  30          


Ala Leu Tyr Glu Glu Pro Glu Lys Pro Asn Ser Ala Leu Asp Phe Leu 
        35                  40                  45              


Lys His His Leu Gly Ala Ala Thr Pro Glu Asn Pro Glu Ile Glu Leu 
    50                  55                  60                  


Leu Arg Leu Glu Leu Ala Glu Met Lys Glu Lys Tyr Glu Ala Ile Val 
65                  70                  75                  80  


Glu Glu Asn Lys Lys Leu Lys Ala Lys Leu Ala Gln Tyr Glu Pro Pro 
                85                  90                  95      


Gln Glu Glu Lys Arg Ala Glu 
            100             


<210>  181
<211>  2331
<212>  DNA
<213>  Homosapiens

<400>  181
ttttaaaagc aaggataagc agaaagggac atggatttta gttgatggat gactcactca     60

ctacattcaa ctgaactgaa tctgctctat accagcaaag ggacaaattc agaaaataaa    120

ttgaagatgg ccatgctgta acttctaaac atggtttgct tctcagattt acctaaacta    180

agaaaggttt gctttaagaa atagtgctcc cttcagaatg gaagaattta tctgcctctt    240

atttgatgtg gatcagagct aagatggctg actaaataaa catgggggac tggaatctcc    300

ttggagatac tctggaggaa gttcacatcc actccaccat gattggaaag atctggctca    360

ccatcctgtt catatttcga atgcttgttc tgggtgtagc agctgaagat gtctggaatg    420

atgagcagtc tggcttcatc tgcaatacag aacaaccagg ctgcagaaat gtatgctacg    480

accaggcctt tcctatctcc ctcattagat actgggttct gcaggtgata tttgtgtctt    540

caccatccct ggtctacatg ggccatgcat tgtaccgact gagagttctt gaggaagaga    600

ggcaaaggat gaaagctcag ttaagagtag aactggagga ggtagagttt gaaatgccta    660

gggatcggag gagattggag caagagcttt gtcagctgga gaaaaggaaa ctaaataaag    720

ctccactcag aggaaccttg ctttgcactt atgtgataca cattttcact cgctctgtgg    780

ttgaagttgg attcatgatt ggacagtacc ttttatatgg atttcactta gagccgctat    840

ttaagtgcca tggccacccg tgtccaaata taatcgactg ttttgtctca agaccaacag    900

aaaagacaat attcctatta tttatgcaat ctatagccac tatttcactt ttcttaaaca    960

ttcttgaaat tttccaccta ggttttaaaa agattaaaag agggctttgg ggaaaataca   1020

agttgaagaa ggaacataat gaattccatg caaacaaggc aaaacaaaat gtagccaaat   1080

accagagcac atctgcaaat tcactgaagc gactcccttc tgcccctgat tataatctgt   1140

tagtggaaaa gcaaacacac actgcagtgt accctagttt aaattcatct tctgtattcc   1200

agccaaatcc tgacaatcat agtgtaaatg atgagaaatg cattttggat gaacaggaaa   1260

ctgtactttc taatgagatt tccacactta gtactagttg tagtcatttt caacacatca   1320

gttcaaacaa taacaaagac actcataaaa tatttggaaa agaacttaat ggtaaccagt   1380

taatggaaaa aagagaaact gaaggcaaag acagcaaaag gaactactac tctagaggtc   1440

accgttctat tccaggtgtt gctatagatg gagagaacaa catgaggcag tcaccccaaa   1500

cagttttctc cttgccagct aactgcgatt ggaaaccgcg gtggcttaga gctacatggg   1560

gttcctctac agaacatgaa aaccgggggt cacctcctaa aggtaacctc aagggccagt   1620

tcagaaaggg cacagtcaga acccttcctc cttcacaagg agattctcaa tcacttgaca   1680

ttccaaacac tgctgattct ttgggagggc tgtcctttga gccagggttg gtcagaacct   1740

gtaataatcc tgtttgtcct ccaaatcacg tagtgtccct aacgaacaat ctcattggta   1800

ggcgggttcc cacagatctt cagatctaaa cagcggttgg cttttagaca ttatatatat   1860

tatcagagaa gtagcctagt ggtcgtgggg cacagaaaaa atagataggg gcagctctaa   1920

agaccagctg ttaagacaga caactgcaaa ctcatttaag caagagaaaa acagctctaa   1980

ttcgagattg tgaagcaaca cttctaaatt caaagacata gagttgtcaa atcaggattt   2040

ttttttttta aaatgatatc ctttcgaatg taactgattt tgggaaaatc acatgttcag   2100

aattgaggct aaatggtttg atcaggtttt ctctttgaag agaccacagc cttaggaaat   2160

ggttcttgat ctatacaatt ccaccttgga cactgggtta attctgtttg cccctggaac   2220

acaatcacgt aagtttcctt ctagactggc atcctgatgt gtcttgagta taatcacatg   2280

ttgctaccta gtaaataaaa tcttaagaag atcaaaaaaa aaaaaaaaaa a            2331


<210>  182
<211>  515
<212>  PRT
<213>  Homosapiens

<400>  182

Met Gly Asp Trp Asn Leu Leu Gly Asp Thr Leu Glu Glu Val His Ile 
1               5                   10                  15      


His Ser Thr Met Ile Gly Lys Ile Trp Leu Thr Ile Leu Phe Ile Phe 
            20                  25                  30          


Arg Met Leu Val Leu Gly Val Ala Ala Glu Asp Val Trp Asn Asp Glu 
        35                  40                  45              


Gln Ser Gly Phe Ile Cys Asn Thr Glu Gln Pro Gly Cys Arg Asn Val 
    50                  55                  60                  


Cys Tyr Asp Gln Ala Phe Pro Ile Ser Leu Ile Arg Tyr Trp Val Leu 
65                  70                  75                  80  


Gln Val Ile Phe Val Ser Ser Pro Ser Leu Val Tyr Met Gly His Ala 
                85                  90                  95      


Leu Tyr Arg Leu Arg Val Leu Glu Glu Glu Arg Gln Arg Met Lys Ala 
            100                 105                 110         


Gln Leu Arg Val Glu Leu Glu Glu Val Glu Phe Glu Met Pro Arg Asp 
        115                 120                 125             


Arg Arg Arg Leu Glu Gln Glu Leu Cys Gln Leu Glu Lys Arg Lys Leu 
    130                 135                 140                 


Asn Lys Ala Pro Leu Arg Gly Thr Leu Leu Cys Thr Tyr Val Ile His 
145                 150                 155                 160 


Ile Phe Thr Arg Ser Val Val Glu Val Gly Phe Met Ile Gly Gln Tyr 
                165                 170                 175     


Leu Leu Tyr Gly Phe His Leu Glu Pro Leu Phe Lys Cys His Gly His 
            180                 185                 190         


Pro Cys Pro Asn Ile Ile Asp Cys Phe Val Ser Arg Pro Thr Glu Lys 
        195                 200                 205             


Thr Ile Phe Leu Leu Phe Met Gln Ser Ile Ala Thr Ile Ser Leu Phe 
    210                 215                 220                 


Leu Asn Ile Leu Glu Ile Phe His Leu Gly Phe Lys Lys Ile Lys Arg 
225                 230                 235                 240 


Gly Leu Trp Gly Lys Tyr Lys Leu Lys Lys Glu His Asn Glu Phe His 
                245                 250                 255     


Ala Asn Lys Ala Lys Gln Asn Val Ala Lys Tyr Gln Ser Thr Ser Ala 
            260                 265                 270         


Asn Ser Leu Lys Arg Leu Pro Ser Ala Pro Asp Tyr Asn Leu Leu Val 
        275                 280                 285             


Glu Lys Gln Thr His Thr Ala Val Tyr Pro Ser Leu Asn Ser Ser Ser 
    290                 295                 300                 


Val Phe Gln Pro Asn Pro Asp Asn His Ser Val Asn Asp Glu Lys Cys 
305                 310                 315                 320 


Ile Leu Asp Glu Gln Glu Thr Val Leu Ser Asn Glu Ile Ser Thr Leu 
                325                 330                 335     


Ser Thr Ser Cys Ser His Phe Gln His Ile Ser Ser Asn Asn Asn Lys 
            340                 345                 350         


Asp Thr His Lys Ile Phe Gly Lys Glu Leu Asn Gly Asn Gln Leu Met 
        355                 360                 365             


Glu Lys Arg Glu Thr Glu Gly Lys Asp Ser Lys Arg Asn Tyr Tyr Ser 
    370                 375                 380                 


Arg Gly His Arg Ser Ile Pro Gly Val Ala Ile Asp Gly Glu Asn Asn 
385                 390                 395                 400 


Met Arg Gln Ser Pro Gln Thr Val Phe Ser Leu Pro Ala Asn Cys Asp 
                405                 410                 415     


Trp Lys Pro Arg Trp Leu Arg Ala Thr Trp Gly Ser Ser Thr Glu His 
            420                 425                 430         


Glu Asn Arg Gly Ser Pro Pro Lys Gly Asn Leu Lys Gly Gln Phe Arg 
        435                 440                 445             


Lys Gly Thr Val Arg Thr Leu Pro Pro Ser Gln Gly Asp Ser Gln Ser 
    450                 455                 460                 


Leu Asp Ile Pro Asn Thr Ala Asp Ser Leu Gly Gly Leu Ser Phe Glu 
465                 470                 475                 480 


Pro Gly Leu Val Arg Thr Cys Asn Asn Pro Val Cys Pro Pro Asn His 
                485                 490                 495     


Val Val Ser Leu Thr Asn Asn Leu Ile Gly Arg Arg Val Pro Thr Asp 
            500                 505                 510         


Leu Gln Ile 
        515 


<210>  183
<211>  1838
<212>  DNA
<213>  Homosapiens

<400>  183
agagcgggat cttcagggca gcgggcaacc ccttggccca ggaagcctgg aacgcaagga     60

ccggagggcg tgggctggga cgcccctacc ttggtctttc agggaaaggc cttggaaagc    120

agtcgttgcg ccagacagcc cagggaagag cggcagcctg aggacctagg gccacctgct    180

gttccctggg attcatgtcc ttctggggag gagggaggac ccaggacaat ggctgctgtt    240

catgatctgg agatggagag catgaatctg aatatgggga gagagatgaa agaagagctg    300

gaggaagagg agaaaatgag agaggatggg ggaggtaaag atcgggccaa gagtaaaaag    360

gtccacagga ttgtctcaaa atggatgctg cccgaaaagt cccgaggaac atacttggag    420

agagctaact gcttcccgcc tcccgtgttc atcatctcca tcagcctggc cgagctggca    480

gtgtttattt actatgctgt gtggaagcct cagaaacagt ggatcacgtt ggacacaggc    540

atcttggaga gtccctttat ctacagtcct gagaagaggg aggaagcctg gaggtttatc    600

tcatacatgc tggtacatgc tggagttcag cacatcttgg ggaatctttg tatgcagctt    660

gttttgggta ttcccttgga aatggtccac aaaggcctcc gtgtggggct ggtgtacctg    720

gcaggagtga ttgcagggtc ccttgccagc tccatctttg acccactcag atatcttgtg    780

ggagcttcag gaggagtcta tgctctgatg ggaggctatt ttatgaatgt tctggtgaat    840

tttcaagaaa tgattcctgc ctttggaatt ttcagactgc tgatcatcat cctgataatt    900

gtgttggaca tgggatttgc tctctataga aggttctttg ttcctgaaga tgggtctccg    960

gtgtcttttg cagctcacat tgcaggtgga tttgctggaa tgtccattgg ctacacggtg   1020

tttagctgct ttgataaagc actgctgaaa gatccaaggt tttggatagc aattgctgca   1080

tatttagctt gtgtcttatt tgctgtgttt ttcaacattt tcctatctcc agcaaactga   1140

cctgccccta ttgtaagtca attaataaaa agagccatct ggaggaaata aaaaaaaaag   1200

gaagactcta tgaagaaaca gagaagtctc agaaaaggct aacaatttta tatagaggac   1260

aaaacagcat taaactcatc agttgcaaag attgcctata aaaggacctt aggatttaag   1320

gaaggggctt cttaatgtag aaagggaaga agaagagaga aaagaagggt agtaaaaact   1380

agagattggg gccaggcgca gtggctcacg cctgtaatcc cagcactttg ggaggctgag   1440

gcgggtgaaa tcacctgagg tcatgagttc aagaccagcc tgaccaatat ggtgaaaccc   1500

tgtctctact aaagaaaata caaaaattag ccgggcgtgg tggcgtgtgc ctgtagtccc   1560

agctacttgc gaggctgagg caggagaatt gcttgaacct gggaggcgaa ggttgcagtg   1620

agccgagatt gcgccactgc actccagcct gggtgataga gcgacactcg gtctcaaaaa   1680

acaaaacaaa acaaaacaaa attagagatt gggtctttcc caggcatatg gtattctata   1740

aaacagactt actctccttg gaggatatat tttggagaat gcttcataaa atctatgaat   1800

actgtacaat gctgataata aaaacttttt atacctga                           1838


<210>  184
<211>  303
<212>  PRT
<213>  Homosapiens

<400>  184

Met Ala Ala Val His Asp Leu Glu Met Glu Ser Met Asn Leu Asn Met 
1               5                   10                  15      


Gly Arg Glu Met Lys Glu Glu Leu Glu Glu Glu Glu Lys Met Arg Glu 
            20                  25                  30          


Asp Gly Gly Gly Lys Asp Arg Ala Lys Ser Lys Lys Val His Arg Ile 
        35                  40                  45              


Val Ser Lys Trp Met Leu Pro Glu Lys Ser Arg Gly Thr Tyr Leu Glu 
    50                  55                  60                  


Arg Ala Asn Cys Phe Pro Pro Pro Val Phe Ile Ile Ser Ile Ser Leu 
65                  70                  75                  80  


Ala Glu Leu Ala Val Phe Ile Tyr Tyr Ala Val Trp Lys Pro Gln Lys 
                85                  90                  95      


Gln Trp Ile Thr Leu Asp Thr Gly Ile Leu Glu Ser Pro Phe Ile Tyr 
            100                 105                 110         


Ser Pro Glu Lys Arg Glu Glu Ala Trp Arg Phe Ile Ser Tyr Met Leu 
        115                 120                 125             


Val His Ala Gly Val Gln His Ile Leu Gly Asn Leu Cys Met Gln Leu 
    130                 135                 140                 


Val Leu Gly Ile Pro Leu Glu Met Val His Lys Gly Leu Arg Val Gly 
145                 150                 155                 160 


Leu Val Tyr Leu Ala Gly Val Ile Ala Gly Ser Leu Ala Ser Ser Ile 
                165                 170                 175     


Phe Asp Pro Leu Arg Tyr Leu Val Gly Ala Ser Gly Gly Val Tyr Ala 
            180                 185                 190         


Leu Met Gly Gly Tyr Phe Met Asn Val Leu Val Asn Phe Gln Glu Met 
        195                 200                 205             


Ile Pro Ala Phe Gly Ile Phe Arg Leu Leu Ile Ile Ile Leu Ile Ile 
    210                 215                 220                 


Val Leu Asp Met Gly Phe Ala Leu Tyr Arg Arg Phe Phe Val Pro Glu 
225                 230                 235                 240 


Asp Gly Ser Pro Val Ser Phe Ala Ala His Ile Ala Gly Gly Phe Ala 
                245                 250                 255     


Gly Met Ser Ile Gly Tyr Thr Val Phe Ser Cys Phe Asp Lys Ala Leu 
            260                 265                 270         


Leu Lys Asp Pro Arg Phe Trp Ile Ala Ile Ala Ala Tyr Leu Ala Cys 
        275                 280                 285             


Val Leu Phe Ala Val Phe Phe Asn Ile Phe Leu Ser Pro Ala Asn 
    290                 295                 300             


<210>  185
<211>  1739
<212>  DNA
<213>  Homosapiens

<400>  185
gcttctccgg cggaacccag gctggaccgc gggccccggc ctgggggcca ctgctgccac     60

cgccgccgcc acctcgtctc ctccccgtcc ccgcccagcc ccaggtctcc ccgcctcact    120

cgggcccgtg gccggggtca ctccccgccg cccctccccg cacggatgcc gaaggtgaag    180

gcgctgcagt gcgccctggc gctggagatc agctcagtaa cttgcccagg agtcgtgctt    240

aaagacaaag aggacatcta tcttagcatc tgtgtgtttg gccaatacaa aaagacacaa    300

tgtgtcccag ccacttttcc cctggtcttc aatgccagaa tggtgtttga aaaggtgttc    360

ccggacgcag tagatcctgg agatgtggtt acacagcttg aatatgatac agcagtgttc    420

gagttgatac agctagttcc accagtgggt gaaacactgt ctacgtatga cgaaaataca    480

cgagatttca tgtttccggg tccaaaccaa atgtctggac accatgattc aaaccgccag    540

gttaccatga ggaggatttc tggccttcga ggaaatgctc caaggctgga attttctacg    600

acttcagtga ttactgaatg tctgataagt tcaaggaaat gccacactca ggataaattt    660

atttaccatt tggctccagt tgaaaaatca catggcagac tgcaaaacag aacatcaaga    720

tcacaaaaga aaaaatccaa gtcacctgag agaagtaaat actgtataaa tgcaaaaaac    780

tacgaacagc ctacaatttc ttcaaaatca cactctccat ctccctacac aaaaagacgc    840

atgtgtgagc tatctgaaga caccaggcgg cggctggccc atttaaatct gggaccctat    900

gagttcaaaa aagaaacaga taaacctcca tttgtgatta gacatgttga tcccccaagt    960

cccagggctg atactttatt gggatcttct ggaagagact gtgaaagaga tggatggtca   1020

agggtgcaca atgatcattc tcatcttggc tgctgccgac ccaaggatta taaggttatc   1080

aggacacccc atgggagaga cttcgatgac tctttagaaa aatgtgaaga gtatttgagc   1140

ccaaggtcgt gtagtaagcc ccggcattca gcgaggacct tgctagtcca ttcagcaccc   1200

tcaacaatgc caaagcattc tccaagccct gtgttaaata gagcttctct cagggaaaga   1260

tttcattctg attggtgttc accttcaaac tgcgatgaga tccatgaccg ggtaaaaaat   1320

gtcttgaaat cacatcaggc tcatcaaaga catttatatg atgagagaga cctagagaaa   1380

gatgatgaac tggaactgaa aagaagtctt ttatgtagag actctgccta tgacagtgac   1440

cccgagtata gctcatgtca gcagccacgt ggcactttcc atttggatga cggtgaatac   1500

tggtccaaca gggcagcctc ttataaggga aaatcccacc gacccatctt tgagaacagc   1560

atggacaaga tgtacaggaa cttatacaaa aaggcctgta gttctgcttc acatacacag   1620

gaaagcttct gagaccatcc atgataaacc tcattagtgt ccgtgtcaat ttctcaatga   1680

aaatgtttga tgtgatcaat atctgtattc ctttttttaa aaaaaatggg attataact    1739


<210>  186
<211>  488
<212>  PRT
<213>  Homosapiens

<400>  186

Met Pro Lys Val Lys Ala Leu Gln Cys Ala Leu Ala Leu Glu Ile Ser 
1               5                   10                  15      


Ser Val Thr Cys Pro Gly Val Val Leu Lys Asp Lys Glu Asp Ile Tyr 
            20                  25                  30          


Leu Ser Ile Cys Val Phe Gly Gln Tyr Lys Lys Thr Gln Cys Val Pro 
        35                  40                  45              


Ala Thr Phe Pro Leu Val Phe Asn Ala Arg Met Val Phe Glu Lys Val 
    50                  55                  60                  


Phe Pro Asp Ala Val Asp Pro Gly Asp Val Val Thr Gln Leu Glu Tyr 
65                  70                  75                  80  


Asp Thr Ala Val Phe Glu Leu Ile Gln Leu Val Pro Pro Val Gly Glu 
                85                  90                  95      


Thr Leu Ser Thr Tyr Asp Glu Asn Thr Arg Asp Phe Met Phe Pro Gly 
            100                 105                 110         


Pro Asn Gln Met Ser Gly His His Asp Ser Asn Arg Gln Val Thr Met 
        115                 120                 125             


Arg Arg Ile Ser Gly Leu Arg Gly Asn Ala Pro Arg Leu Glu Phe Ser 
    130                 135                 140                 


Thr Thr Ser Val Ile Thr Glu Cys Leu Ile Ser Ser Arg Lys Cys His 
145                 150                 155                 160 


Thr Gln Asp Lys Phe Ile Tyr His Leu Ala Pro Val Glu Lys Ser His 
                165                 170                 175     


Gly Arg Leu Gln Asn Arg Thr Ser Arg Ser Gln Lys Lys Lys Ser Lys 
            180                 185                 190         


Ser Pro Glu Arg Ser Lys Tyr Cys Ile Asn Ala Lys Asn Tyr Glu Gln 
        195                 200                 205             


Pro Thr Ile Ser Ser Lys Ser His Ser Pro Ser Pro Tyr Thr Lys Arg 
    210                 215                 220                 


Arg Met Cys Glu Leu Ser Glu Asp Thr Arg Arg Arg Leu Ala His Leu 
225                 230                 235                 240 


Asn Leu Gly Pro Tyr Glu Phe Lys Lys Glu Thr Asp Lys Pro Pro Phe 
                245                 250                 255     


Val Ile Arg His Val Asp Pro Pro Ser Pro Arg Ala Asp Thr Leu Leu 
            260                 265                 270         


Gly Ser Ser Gly Arg Asp Cys Glu Arg Asp Gly Trp Ser Arg Val His 
        275                 280                 285             


Asn Asp His Ser His Leu Gly Cys Cys Arg Pro Lys Asp Tyr Lys Val 
    290                 295                 300                 


Ile Arg Thr Pro His Gly Arg Asp Phe Asp Asp Ser Leu Glu Lys Cys 
305                 310                 315                 320 


Glu Glu Tyr Leu Ser Pro Arg Ser Cys Ser Lys Pro Arg His Ser Ala 
                325                 330                 335     


Arg Thr Leu Leu Val His Ser Ala Pro Ser Thr Met Pro Lys His Ser 
            340                 345                 350         


Pro Ser Pro Val Leu Asn Arg Ala Ser Leu Arg Glu Arg Phe His Ser 
        355                 360                 365             


Asp Trp Cys Ser Pro Ser Asn Cys Asp Glu Ile His Asp Arg Val Lys 
    370                 375                 380                 


Asn Val Leu Lys Ser His Gln Ala His Gln Arg His Leu Tyr Asp Glu 
385                 390                 395                 400 


Arg Asp Leu Glu Lys Asp Asp Glu Leu Glu Leu Lys Arg Ser Leu Leu 
                405                 410                 415     


Cys Arg Asp Ser Ala Tyr Asp Ser Asp Pro Glu Tyr Ser Ser Cys Gln 
            420                 425                 430         


Gln Pro Arg Gly Thr Phe His Leu Asp Asp Gly Glu Tyr Trp Ser Asn 
        435                 440                 445             


Arg Ala Ala Ser Tyr Lys Gly Lys Ser His Arg Pro Ile Phe Glu Asn 
    450                 455                 460                 


Ser Met Asp Lys Met Tyr Arg Asn Leu Tyr Lys Lys Ala Cys Ser Ser 
465                 470                 475                 480 


Ala Ser His Thr Gln Glu Ser Phe 
                485             


<210>  187
<211>  3938
<212>  DNA
<213>  Homosapiens

<400>  187
accgagaaga agatatttac cagtttgctt actgctaccc atatacatac actcgcttcc     60

aacattacct tgacagcctg caaaagagaa acatggatta cttctttcgg gagcagctgg    120

gccagagtgt gcaacaacga aagcttgacc tcctgacgat aaccagccct gacaatctcc    180

gggaaggggc agagcagaag gtggtattca tcacaggacg agtccaccca ggggaaacac    240

cctcatcatt tgtgtgccaa gggatcattg acttccttgt aagccagcac cctattgcct    300

gtgtcctccg ggaatacctg gtcttcaaga tcgcaccaat gctcaatcct gatggagtct    360

acctgggcaa ttacaggtgt tctctgatgg gatttgatct gaatcgtcac tggctggatc    420

cctctccatg ggtccatcct accctgcatg gagtgaaaca actcatcgtc cagatgtaca    480

acgacccaaa aacaagcctg gagttttata ttgacatcca tgcccactcc accatgatga    540

atggcttcat gtatggcaac atctttgagg atgaggaacg gttccagagg caggccattt    600

ttcccaagct cctctgccag aatgctgagg acttctccta ttccagcaca ccctttaacc    660

gggacgctgt gaaagcagga actggccgtc gcttcctcgg tggactcctg gaccacactt    720

cctattgcta caccctagag gtctccttct acagctacat catcagtggc accacggctg    780

ctgtgcccta cactgaagaa gcctgtatcc ttagtcccca cccagccttg ggccagccct    840

catccagccg agagtatcca agtctgacag gtcaggaatt aggcccccag ctcaggtaag    900

ggctgagact ctcaggtgag gatggaggtg cttcttcttc tggtggcgtc tttggattgt    960

ccagtttgcc tcagccctta gtatgatact cctaccccaa ttgccatgct ccaaatcttt   1020

cccaggccag ccggacccat ggcctgccca tatcttactc tgcttccatc tctctcccct   1080

ctcttctctc atgatgcagt gagtctcctg ccatctaagc tatgcaagtc cacaggctgg   1140

atgaccatcc ccagggttgc tgaggaagag cttgatgatc ttgactcctt ctaaccctga   1200

acatacaaaa acatatgttc tcttttcatc ttttgtctaa cctatcctct cccactttct   1260

cttccctcta ctcactattt ccccttctac ttacttttct cacccttgtt ccctctcctt   1320

ctatgccctc ctcctccctc ctcacctgtc ctgtgcttct ctttccttac ttctttttcc   1380

ccctcctccc ctcctttctg tcctctctct catcccatcc tccttttctt tctctcctct   1440

ttgcctgtct tctgtcttcc ttgtctttcc cctctcatcc tctgtgcatc tttctctctg   1500

cctttgcatt tcctttgaca aattcctttt cctcttagtt tcttcataaa atttctctga   1560

aaactccaaa gccttccatg atgaaattag aagttatttt ctagtttgcc taatttttta   1620

aggattaggt agtaactcta gtttcccgag tgttgatttt aatatcaagg tcactgcatc   1680

agagctgtaa cagatcgtgg cagattctgc tttccttgat cctttgtttt cgggttgatc   1740

tatgtctcct ttcctaacac ttagttttct cagagaagtg gagggaggag gaaggaactt   1800

tagatgaaat gaactctgta tttctgcaaa ttccccctcc ctggaggtag aagtgctctt   1860

ttagcatttt ttcaaccctt ggtgagtgtt tatggaattc ctctgtgcag ggaaacatct   1920

tttctgaacg tggcatgact tagggctagt cccaccagcc aactgcaact tagtggctct   1980

gtttgtatgt gtgtttggga gggttggggg tatggtgtcc aggtaccttg ccaggaacat   2040

cggaagtagg gcaatggccc tagaaggagg ggctgtcagg gggtaggcca ggtgttagag   2100

caatgttcca catcctgttg gacacagaga tattatgatt ggaactgaga gttccctatg   2160

tacagtcatc aagactgagg gtcatcttgc agtctgcttt aatacccacc tgactcagca   2220

aggccaaggg agtaggctct gctctgagga agagggtctg tgggttccaa agtcctggcc   2280

acctgttatg tgccacattg cccctcttca tgccccatac acaccttaga tgatgcatat   2340

ggcctatgcc ttctccagaa tctgctaact cctataacac atgcatatgc ttcattccac   2400

attgtacttg ctttgctctc ccataatatt atggcaaagg gacagagagc tgcctggaat   2460

aagagtttga gcttgtgcac taaaggggat tctgcaaccc ttattcatag tgagatgagg   2520

gtccctccag aggaggcctg cccttagttt gttgtttttt gctgtccaat ctgacaggct   2580

ctcctacctt ttcttagcac ttctgacatg cttctgtctt agaagaaaat gtgtttctta   2640

gtagaaagcc cacccttggt tcaggcccaa ggtttccacc cctcaacagc caacactcat   2700

ttatcaaaag taaacacagc attagtacat accaggaatc ataaaaggca cctagggtaa   2760

aatactgaat aaaaaggcat gattcctgac tcacagaact ttcagtctac ttggggagac   2820

agaaaaggga agagataatt acaatgtatg tgataaattc tggtggagga attccagaag   2880

gctctgggac attttcattt gacaagtata tattgagtgc ctgtcatagg tcaggtaaag   2940

ttctaggcac agggaatgta acagagaaca tactaaagac aagaatgtct ttacatgggg   3000

gaaagaggga actcacacgc agtcctagga gtcagggaag atttcccagg aaaagagaca   3060

tctaaactga gattttttgt ttgtttgttt ttgagatgga gtctcactct gttacccagg   3120

ctagagtgta gtggcatgat ctcagctcac tgcaacttct gcctcctggg ttcaagcgat   3180

tcccctgcct cagcctcctg agtagctggg attacaggtg tgcgccacca tgtccggcta   3240

atttttgtat ttttagcaga gatggggttt taccatgttg gtcaggctgg tctcaaactt   3300

ctgacctcgt gatccacctg cttcggcctc ccaaagtgct gagattacag gtgtaagcca   3360

ctgagcccgg cctaaactga gtttttaata tgaactagtc aaactgggtg agggtgttgt   3420

tgaagggagg atgtggtaga cagagggggg agtacagaag gtatgggcag aagctgtaag   3480

tggtccctta gggctgaagg acttcagact caatgataag tctgaagtgg aaagatgtaa   3540

gaagtttgat cttgaatgta gacaatggaa ggacagattc gagggggcca gtattgtaga   3600

cagggacatg cattaggagg ctgttataaa aatccaggtg agaaataatc caggccaaga   3660

ccagagtggt ggctgtagaa tacttagaat gtggaactga gaagacttgg taattgacta   3720

tttgggagtg gcgacaggga atgggagctc gtgattggaa ggggttaagg tgagtagaga   3780

ggctatgcac aagctgagca ggtcgtgata ctgatggacc taccctgcct tgttctgtcc   3840

tctagaggat gagaagagga aacaaactgc accagggaag ctcaggccga ttcaatgcat   3900

gcaagggtga tttaacctgg gttctgtttg aaatactt                           3938


<210>  188
<211>  268
<212>  PRT
<213>  Homosapiens

<400>  188

Met Asp Tyr Phe Phe Arg Glu Gln Leu Gly Gln Ser Val Gln Gln Arg 
1               5                   10                  15      


Lys Leu Asp Leu Leu Thr Ile Thr Ser Pro Asp Asn Leu Arg Glu Gly 
            20                  25                  30          


Ala Glu Gln Lys Val Val Phe Ile Thr Gly Arg Val His Pro Gly Glu 
        35                  40                  45              


Thr Pro Ser Ser Phe Val Cys Gln Gly Ile Ile Asp Phe Leu Val Ser 
    50                  55                  60                  


Gln His Pro Ile Ala Cys Val Leu Arg Glu Tyr Leu Val Phe Lys Ile 
65                  70                  75                  80  


Ala Pro Met Leu Asn Pro Asp Gly Val Tyr Leu Gly Asn Tyr Arg Cys 
                85                  90                  95      


Ser Leu Met Gly Phe Asp Leu Asn Arg His Trp Leu Asp Pro Ser Pro 
            100                 105                 110         


Trp Val His Pro Thr Leu His Gly Val Lys Gln Leu Ile Val Gln Met 
        115                 120                 125             


Tyr Asn Asp Pro Lys Thr Ser Leu Glu Phe Tyr Ile Asp Ile His Ala 
    130                 135                 140                 


His Ser Thr Met Met Asn Gly Phe Met Tyr Gly Asn Ile Phe Glu Asp 
145                 150                 155                 160 


Glu Glu Arg Phe Gln Arg Gln Ala Ile Phe Pro Lys Leu Leu Cys Gln 
                165                 170                 175     


Asn Ala Glu Asp Phe Ser Tyr Ser Ser Thr Pro Phe Asn Arg Asp Ala 
            180                 185                 190         


Val Lys Ala Gly Thr Gly Arg Arg Phe Leu Gly Gly Leu Leu Asp His 
        195                 200                 205             


Thr Ser Tyr Cys Tyr Thr Leu Glu Val Ser Phe Tyr Ser Tyr Ile Ile 
    210                 215                 220                 


Ser Gly Thr Thr Ala Ala Val Pro Tyr Thr Glu Glu Ala Cys Ile Leu 
225                 230                 235                 240 


Ser Pro His Pro Ala Leu Gly Gln Pro Ser Ser Ser Arg Glu Tyr Pro 
                245                 250                 255     


Ser Leu Thr Gly Gln Glu Leu Gly Pro Gln Leu Arg 
            260                 265             


<210>  189
<211>  2610
<212>  DNA
<213>  Homosapiens

<400>  189
caggggcgga ggcggcggcc agggaggaag cggaggaggc ggaggcggcc gcggcgttcg     60

cccgcccgct cgctcgctcg gtttccccgc ccccgccggg cttaacgccg ctgaaggtat    120

ccgggtgcgc gctgtcgcaa cctgccctca tcctggcccg cgactgtaag accggaccca    180

catccagacc aatcttcctg tccgggctgc tgcgacgcgg gctccgcagg ttgcaggcgg    240

gcggccgggg cgcctgaagg ttaccgagtg catgagcgcc tagcgcttcc cgcgctgccc    300

cgcccgctgg cccgccgacc cgcccgccgg ctcgcccgcc agcccctcgg cgcccggcgg    360

cggcggcggc ggtggcggcg acggtcgcag gaggtgccgt ctgcctccca ggtgcgcgct    420

tcgctcccgg agccgcggaa ctcggcggcc gccatggcgt ccaacatgga ccgggagatg    480

atcctggcgg attttcaggc atgtactggc attgaaaaca ttgacgaagc tattacattg    540

cttgaacaaa ataattggga cttagtggca gctatcaatg gtgtaatacc acaggaaaat    600

ggcattctac aaagtgaata tggaggtgag accataccag gacctgcatt taatccagca    660

agtcatccag cttcagctcc tacttcctct tcttcttcag cgtttcgacc tgtaatgcca    720

tccaggcaga ttgtagaaag gcaacctcgg atgctggact tcagggttga atacagagac    780

agaaatgttg atgtggtact tgaagacacc tgtactgttg gagagattaa acagattcta    840

gaaaatgaac ttcagatacc tgtgtccaaa atgctgttaa aaggctggaa gacgggagat    900

gtggaagaca gtacggtcct aaaatctcta cacttgccaa aaaacaacag tctttatgtc    960

cttacaccag atttgccacc accttcatca tctagtcatg ctggtgccct gcaggagtca   1020

ttaaatcaaa acttcatgct gatcatcacc caccgagaag tccagcggga gtacaacctg   1080

aacttctcag gaagcagtac tattcaagag gtaaagagaa atgtgtatga ccttacaagt   1140

atccccgttc gccaccaatt atgggagggc tggccaactt ctgctacaga cgactcaatg   1200

tgtcttgctg aatcagggct ctcttatccc tgccatcgac ttacagtggg aagaagatct   1260

tcacctgcac agacccggga acagtcggaa gaacaaatca ccgatgttca tatggttagt   1320

gatagcgatg gagatgactt tgaagatgct acagaatttg gggtggatga tggagaagta   1380

tttggcatgg cgtcatctgc cttgagaaaa tctccaatga tgccagaaaa cgcagaaaat   1440

gaaggagatg ccttattaca atttacagca gagttttctt caagatatgg tgattgccat   1500

cctgtatttt ttattggctc attagaagct gcttttcaag aggccttcta tgtgaaagcc   1560

cgagatagaa agcttcttgc tatctacctc caccatgatg aaagtgtgtt aaccaacgtg   1620

ttctgctcac aaatgctttg tgctgaatcc attgtttctt atctgagtca aaattttata   1680

acctgggctt gggatctgac aaaggactcc aacagagcaa gatttctcac tatgtgcaat   1740

agacactttg gcagtgttgt ggcacaaacc attcggactc aaaaaacgga tcagtttccg   1800

cttttcctga ttattatggg aaagcgatca tctaatgaag tgttgaatgt gatacaaggg   1860

aacacaacag tagatgagtt aatgatgaga ctcatggctg caatggagat cttcacagcc   1920

caacaacagg aagatataaa ggacgaggat gaacgtgaag ccagagaaaa tgtgaagaga   1980

gagcaagatg aggcctatcg cctttcactt gaggctgaca gagcaaagag ggaagctcac   2040

gagagagaga tggcagaaca gtttcgtttg gagcagattc gcaaagaaca agaagaggaa   2100

cgtgaggcca tccggctgtc cttagagcaa gccctgcctc ctgagccaaa ggaagaaaat   2160

gctgagcctg tgagcaaact gcggatccgg acccccagtg gcgagttctt ggagcggcgt   2220

ttcctggcca gcaacaagct ccagattgtc tttgattttg tagcttccaa aggatttcca   2280

tgggatgagt acaagttact gagcaccttt cctaggagag acgtaactca actggaccca   2340

aataaatcat tattggaggt aaagttgttc cctcaagaaa cccttttcct tgaagcaaaa   2400

gagtaaacac ggcccagcgg tggaaccagc cattccttga caagccagca gcctgcgtca   2460

ggagaagggc tcctcgccaa cccacccaca cgctcgtctc actcaattca atgtcacact   2520

tctgcctctt gcaaaattgc tggaaaaagt aataataaat atagctactt aagatttccc   2580

atcaaaaaaa aaaaaaaaaa aaaaaaaaaa                                    2610


<210>  190
<211>  650
<212>  PRT
<213>  Homosapiens

<400>  190

Met Ala Ser Asn Met Asp Arg Glu Met Ile Leu Ala Asp Phe Gln Ala 
1               5                   10                  15      


Cys Thr Gly Ile Glu Asn Ile Asp Glu Ala Ile Thr Leu Leu Glu Gln 
            20                  25                  30          


Asn Asn Trp Asp Leu Val Ala Ala Ile Asn Gly Val Ile Pro Gln Glu 
        35                  40                  45              


Asn Gly Ile Leu Gln Ser Glu Tyr Gly Gly Glu Thr Ile Pro Gly Pro 
    50                  55                  60                  


Ala Phe Asn Pro Ala Ser His Pro Ala Ser Ala Pro Thr Ser Ser Ser 
65                  70                  75                  80  


Ser Ser Ala Phe Arg Pro Val Met Pro Ser Arg Gln Ile Val Glu Arg 
                85                  90                  95      


Gln Pro Arg Met Leu Asp Phe Arg Val Glu Tyr Arg Asp Arg Asn Val 
            100                 105                 110         


Asp Val Val Leu Glu Asp Thr Cys Thr Val Gly Glu Ile Lys Gln Ile 
        115                 120                 125             


Leu Glu Asn Glu Leu Gln Ile Pro Val Ser Lys Met Leu Leu Lys Gly 
    130                 135                 140                 


Trp Lys Thr Gly Asp Val Glu Asp Ser Thr Val Leu Lys Ser Leu His 
145                 150                 155                 160 


Leu Pro Lys Asn Asn Ser Leu Tyr Val Leu Thr Pro Asp Leu Pro Pro 
                165                 170                 175     


Pro Ser Ser Ser Ser His Ala Gly Ala Leu Gln Glu Ser Leu Asn Gln 
            180                 185                 190         


Asn Phe Met Leu Ile Ile Thr His Arg Glu Val Gln Arg Glu Tyr Asn 
        195                 200                 205             


Leu Asn Phe Ser Gly Ser Ser Thr Ile Gln Glu Val Lys Arg Asn Val 
    210                 215                 220                 


Tyr Asp Leu Thr Ser Ile Pro Val Arg His Gln Leu Trp Glu Gly Trp 
225                 230                 235                 240 


Pro Thr Ser Ala Thr Asp Asp Ser Met Cys Leu Ala Glu Ser Gly Leu 
                245                 250                 255     


Ser Tyr Pro Cys His Arg Leu Thr Val Gly Arg Arg Ser Ser Pro Ala 
            260                 265                 270         


Gln Thr Arg Glu Gln Ser Glu Glu Gln Ile Thr Asp Val His Met Val 
        275                 280                 285             


Ser Asp Ser Asp Gly Asp Asp Phe Glu Asp Ala Thr Glu Phe Gly Val 
    290                 295                 300                 


Asp Asp Gly Glu Val Phe Gly Met Ala Ser Ser Ala Leu Arg Lys Ser 
305                 310                 315                 320 


Pro Met Met Pro Glu Asn Ala Glu Asn Glu Gly Asp Ala Leu Leu Gln 
                325                 330                 335     


Phe Thr Ala Glu Phe Ser Ser Arg Tyr Gly Asp Cys His Pro Val Phe 
            340                 345                 350         


Phe Ile Gly Ser Leu Glu Ala Ala Phe Gln Glu Ala Phe Tyr Val Lys 
        355                 360                 365             


Ala Arg Asp Arg Lys Leu Leu Ala Ile Tyr Leu His His Asp Glu Ser 
    370                 375                 380                 


Val Leu Thr Asn Val Phe Cys Ser Gln Met Leu Cys Ala Glu Ser Ile 
385                 390                 395                 400 


Val Ser Tyr Leu Ser Gln Asn Phe Ile Thr Trp Ala Trp Asp Leu Thr 
                405                 410                 415     


Lys Asp Ser Asn Arg Ala Arg Phe Leu Thr Met Cys Asn Arg His Phe 
            420                 425                 430         


Gly Ser Val Val Ala Gln Thr Ile Arg Thr Gln Lys Thr Asp Gln Phe 
        435                 440                 445             


Pro Leu Phe Leu Ile Ile Met Gly Lys Arg Ser Ser Asn Glu Val Leu 
    450                 455                 460                 


Asn Val Ile Gln Gly Asn Thr Thr Val Asp Glu Leu Met Met Arg Leu 
465                 470                 475                 480 


Met Ala Ala Met Glu Ile Phe Thr Ala Gln Gln Gln Glu Asp Ile Lys 
                485                 490                 495     


Asp Glu Asp Glu Arg Glu Ala Arg Glu Asn Val Lys Arg Glu Gln Asp 
            500                 505                 510         


Glu Ala Tyr Arg Leu Ser Leu Glu Ala Asp Arg Ala Lys Arg Glu Ala 
        515                 520                 525             


His Glu Arg Glu Met Ala Glu Gln Phe Arg Leu Glu Gln Ile Arg Lys 
    530                 535                 540                 


Glu Gln Glu Glu Glu Arg Glu Ala Ile Arg Leu Ser Leu Glu Gln Ala 
545                 550                 555                 560 


Leu Pro Pro Glu Pro Lys Glu Glu Asn Ala Glu Pro Val Ser Lys Leu 
                565                 570                 575     


Arg Ile Arg Thr Pro Ser Gly Glu Phe Leu Glu Arg Arg Phe Leu Ala 
            580                 585                 590         


Ser Asn Lys Leu Gln Ile Val Phe Asp Phe Val Ala Ser Lys Gly Phe 
        595                 600                 605             


Pro Trp Asp Glu Tyr Lys Leu Leu Ser Thr Phe Pro Arg Arg Asp Val 
    610                 615                 620                 


Thr Gln Leu Asp Pro Asn Lys Ser Leu Leu Glu Val Lys Leu Phe Pro 
625                 630                 635                 640 


Gln Glu Thr Leu Phe Leu Glu Ala Lys Glu 
                645                 650 


<210>  191
<211>  2154
<212>  DNA
<213>  Homosapiens

<400>  191
caggggcgga ggcggcggcc agggaggaag cggaggaggc ggaggcggcc gcggcgttcg     60

cccgcccgct cgctcgctcg gtttccccgc ccccgccggg cttaacgccg ctgaaggtat    120

ccgggtgcgc gctgtcgcaa cctgccctca tcctggcccg cgactgtaag accggaccca    180

catccagacc aatcttcctg tccgggctgc tgcgacgcgg gctccgcagg ttgcaggcgg    240

gcggccgggg cgcctgaagg ttaccgagtg catgagcgcc tagcgcttcc cgcgctgccc    300

cgcccgctgg cccgccgacc cgcccgccgg ctcgcccgcc agcccctcgg cgcccggcgg    360

cggcggcggc ggtggcggcg acggtcgcag gaggtgccgt ctgcctccca ggtgcgcgct    420

tcgctcccgg agccgcggaa ctcggcggcc gccatggcgt ccaacatgga ccgggagatg    480

atcctggcgg attttcaggc atgtactggc attgaaaaca ttgacgaagc tattacattg    540

cttgaacaaa ataattggga cttagtggca gctatcaatg gtgtaatacc acaggaaaat    600

ggcattctac aaagtgaata tggaggtgag accataccag gacctgcatt taatccagca    660

agtcatccag cttcagctcc tacttcctct tcttcttcag cgtttcgacc tgtaatgcca    720

tccaggcaga ttgtagaaag gcaacctcgg atgctggact tcagggttga atacagagac    780

agaaatgttg atgtggtact tgaagacacc tgtactgttg gagagattaa acagattcta    840

gaaaatgaac ttcagatacc tgtgtccaaa atgctgttaa aaggctggaa gacgggagat    900

gtggaagaca gtacggtcct aaaatctcta cacttgccaa aaaacaacag tctttatgtc    960

cttacaccag atttgccacc accttcatca tctagtcatg ctggtgccct gcaggagttt   1020

tcttcaagat atggtgattg ccatcctgta ttttttattg gctcattaga agctgctttt   1080

caagaggcct tctatgtgaa agcccgagat agaaagcttc ttgctatcta cctccaccat   1140

gatgaaagtg tgttaaccaa cgtgttctgc tcacaaatgc tttgtgctga atccattgtt   1200

tcttatctga gtcaaaattt tataacctgg gcttgggatc tgacaaagga ctccaacaga   1260

gcaagatttc tcactatgtg caatagacac tttggcagtg ttgtggcaca aaccattcgg   1320

actcaaaaaa cggatcagtt tccgcttttc ctgattatta tgggaaagcg atcatctaat   1380

gaagtgttga atgtgataca agggaacaca acagtagatg agttaatgat gagactcatg   1440

gctgcaatgg agatcttcac agcccaacaa caggaagata taaaggacga ggatgaacgt   1500

gaagccagag aaaatgtgaa gagagagcaa gatgaggcct atcgcctttc acttgaggct   1560

gacagagcaa agagggaagc tcacgagaga gagatggcag aacagtttcg tttggagcag   1620

attcgcaaag aacaagaaga ggaacgtgag gccatccggc tgtccttaga gcaagccctg   1680

cctcctgagc caaaggaaga aaatgctgag cctgtgagca aactgcggat ccggaccccc   1740

agtggcgagt tcttggagcg gcgtttcctg gccagcaaca agctccagat tgtctttgat   1800

tttgtagctt ccaaaggatt tccatgggat gagtacaagt tactgagcac ctttcctagg   1860

agagacgtaa ctcaactgga cccaaataaa tcattattgg aggtaaagtt gttccctcaa   1920

gaaacccttt tccttgaagc aaaagagtaa acacggccca gcggtggaac cagccattcc   1980

ttgacaagcc agcagcctgc gtcaggagaa gggctcctcg ccaacccacc cacacgctcg   2040

tctcactcaa ttcaatgtca cacttctgcc tcttgcaaaa ttgctggaaa aagtaataat   2100

aaatatagct acttaagatt tcccatcaaa aaaaaaaaaa aaaaaaaaaa aaaa         2154


<210>  192
<211>  498
<212>  PRT
<213>  Homosapiens

<400>  192

Met Ala Ser Asn Met Asp Arg Glu Met Ile Leu Ala Asp Phe Gln Ala 
1               5                   10                  15      


Cys Thr Gly Ile Glu Asn Ile Asp Glu Ala Ile Thr Leu Leu Glu Gln 
            20                  25                  30          


Asn Asn Trp Asp Leu Val Ala Ala Ile Asn Gly Val Ile Pro Gln Glu 
        35                  40                  45              


Asn Gly Ile Leu Gln Ser Glu Tyr Gly Gly Glu Thr Ile Pro Gly Pro 
    50                  55                  60                  


Ala Phe Asn Pro Ala Ser His Pro Ala Ser Ala Pro Thr Ser Ser Ser 
65                  70                  75                  80  


Ser Ser Ala Phe Arg Pro Val Met Pro Ser Arg Gln Ile Val Glu Arg 
                85                  90                  95      


Gln Pro Arg Met Leu Asp Phe Arg Val Glu Tyr Arg Asp Arg Asn Val 
            100                 105                 110         


Asp Val Val Leu Glu Asp Thr Cys Thr Val Gly Glu Ile Lys Gln Ile 
        115                 120                 125             


Leu Glu Asn Glu Leu Gln Ile Pro Val Ser Lys Met Leu Leu Lys Gly 
    130                 135                 140                 


Trp Lys Thr Gly Asp Val Glu Asp Ser Thr Val Leu Lys Ser Leu His 
145                 150                 155                 160 


Leu Pro Lys Asn Asn Ser Leu Tyr Val Leu Thr Pro Asp Leu Pro Pro 
                165                 170                 175     


Pro Ser Ser Ser Ser His Ala Gly Ala Leu Gln Glu Phe Ser Ser Arg 
            180                 185                 190         


Tyr Gly Asp Cys His Pro Val Phe Phe Ile Gly Ser Leu Glu Ala Ala 
        195                 200                 205             


Phe Gln Glu Ala Phe Tyr Val Lys Ala Arg Asp Arg Lys Leu Leu Ala 
    210                 215                 220                 


Ile Tyr Leu His His Asp Glu Ser Val Leu Thr Asn Val Phe Cys Ser 
225                 230                 235                 240 


Gln Met Leu Cys Ala Glu Ser Ile Val Ser Tyr Leu Ser Gln Asn Phe 
                245                 250                 255     


Ile Thr Trp Ala Trp Asp Leu Thr Lys Asp Ser Asn Arg Ala Arg Phe 
            260                 265                 270         


Leu Thr Met Cys Asn Arg His Phe Gly Ser Val Val Ala Gln Thr Ile 
        275                 280                 285             


Arg Thr Gln Lys Thr Asp Gln Phe Pro Leu Phe Leu Ile Ile Met Gly 
    290                 295                 300                 


Lys Arg Ser Ser Asn Glu Val Leu Asn Val Ile Gln Gly Asn Thr Thr 
305                 310                 315                 320 


Val Asp Glu Leu Met Met Arg Leu Met Ala Ala Met Glu Ile Phe Thr 
                325                 330                 335     


Ala Gln Gln Gln Glu Asp Ile Lys Asp Glu Asp Glu Arg Glu Ala Arg 
            340                 345                 350         


Glu Asn Val Lys Arg Glu Gln Asp Glu Ala Tyr Arg Leu Ser Leu Glu 
        355                 360                 365             


Ala Asp Arg Ala Lys Arg Glu Ala His Glu Arg Glu Met Ala Glu Gln 
    370                 375                 380                 


Phe Arg Leu Glu Gln Ile Arg Lys Glu Gln Glu Glu Glu Arg Glu Ala 
385                 390                 395                 400 


Ile Arg Leu Ser Leu Glu Gln Ala Leu Pro Pro Glu Pro Lys Glu Glu 
                405                 410                 415     


Asn Ala Glu Pro Val Ser Lys Leu Arg Ile Arg Thr Pro Ser Gly Glu 
            420                 425                 430         


Phe Leu Glu Arg Arg Phe Leu Ala Ser Asn Lys Leu Gln Ile Val Phe 
        435                 440                 445             


Asp Phe Val Ala Ser Lys Gly Phe Pro Trp Asp Glu Tyr Lys Leu Leu 
    450                 455                 460                 


Ser Thr Phe Pro Arg Arg Asp Val Thr Gln Leu Asp Pro Asn Lys Ser 
465                 470                 475                 480 


Leu Leu Glu Val Lys Leu Phe Pro Gln Glu Thr Leu Phe Leu Glu Ala 
                485                 490                 495     


Lys Glu 
        


<210>  193
<211>  2104
<212>  DNA
<213>  Homosapiens

<400>  193
ctctgccgag cctccttaaa actctgccgt taaaatgggg gcgggttttt caactcaaaa     60

agcgctcaat ttttttcttt tcaaaaaaag ctgatgaggt cggaaaaaag ggagaagaaa    120

ccggcaccct ctctgagagg caacagaagc agcaattgtt tcagcgaaaa aagcagcaag    180

ggagggagtg aaggaaaaaa gcaaaaaagg gggcgacacg caagtgcctg taggggtgaa    240

aggagcaggg accggcgatc taggggggga tcagctacaa aagaaactgt cactgggagc    300

ggtgcggcca aggaggaagc agtgctgcca ggctctgctc cagggcacag ctggctggcg    360

gctgccctgt ccgcagcaaa ggggcacagg ccggggaccg cgagaggtgg caaagtggca    420

ccgggcgccg aggctgctga gcgctcgccg agacggcgac cggactggct gccccggaac    480

tgcggcgact ctccctactc agaacttggc ctacgtttcc caggactctc cccatctcca    540

gaggccccca caaaaccggg aaaggaagga aaggacagcg gcggcagcag ctcaatgagt    600

gcctacagca gaaagcctga acgagctcgg tcgtaggcgg gaagttcccg ggggggctgc    660

ccagtgcagc cgcaatgctg ccgcgagctg ccccagcagt ccgggctccg tagacgcttt    720

ccgcatcact ctccttcctc gggctgccgg gagtcccggg acctggcggg gccggcatga    780

cgggcttctc gggggcccgc cgcacgcccg gcagcctccg gagacgcgcg ccgagcccgg    840

ctcccacggc ctctgaggct cggcggggct gcggctgcct ggcgggcggg ctccggagct    900

ttcctgagcg gcattagccc acggcttggc ccggacgcga ccaaaggctc ttctggagaa    960

gcccagagca ctgggcaatc gttacgacct gtaacttgag ggccaccgaa ctgctactcc   1020

cgttcgcctt tggcgatcat cttttaaccc tccggagcac gtcagcatcc agccaccgcg   1080

gcgctctccc agcagcggag gacccaggac tatcccttcg gcgagacgga tggaaaccga   1140

gccccctgga ggacctgccc ctgcagttct gcctcacacg gctcaagtca ccaccgtgaa   1200

caagggaccc taaagaatgg ccgagccttg ggggaacgag ttggcgtccg cagctgccag   1260

gggggaccta gagcaactta ctagtttgtt gcaaaataat gtaaacgtca atgcacaaaa   1320

tggatttgga aggactgcgc tgcaggttat gaaacttgga aatcccgaga ttgccaggag   1380

actgctactt agaggtgcta atcccgattt gaaagaccga actggtttcg ctgtcattca   1440

tgatgcggcc agagcaggtt tcctggacac tttacagact ttgctggagt ttcaagctga   1500

tgttaacatc gaggataatg aagggaacct gcccttgcac ttggctgcca aagaaggcca   1560

cctccgggtg gtggagttcc tggtgaagca cacggccagc aatgtggggc atcggaacca   1620

taagggggac accgcctgtg atttggccag gctctatggg aggaatgagg ttgttagcct   1680

gatgcaggca aacggggctg ggggagccac aaatcttcaa taaacgtggg gagggctccc   1740

ccacgttgcc tctactttat caattaactg agtagctctc ctgactttta atgtcatttg   1800

ttaaaataca gttctgtcat atgttaagca gctaaatttt ctgaaactgc ataagtgaaa   1860

atcttacaac aggcttatga atatatttaa gcaacatctt tttaacctgc aaaatctgtt   1920

ctaacatgta attgcagata actttgactt tcttctgaat attttatctt tccttggctt   1980

ttcccttgct tccccttttg ccaatctcaa cacccaagtt gaagactttg tttttaaaat   2040

ggtttgtcct gatgcttttg tctaattaaa acactttcaa aacaggaaaa aaaaaaaaaa   2100

aaaa                                                                2104


<210>  194
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  194

Met Ala Glu Pro Trp Gly Asn Glu Leu Ala Ser Ala Ala Ala Arg Gly 
1               5                   10                  15      


Asp Leu Glu Gln Leu Thr Ser Leu Leu Gln Asn Asn Val Asn Val Asn 
            20                  25                  30          


Ala Gln Asn Gly Phe Gly Arg Thr Ala Leu Gln Val Met Lys Leu Gly 
        35                  40                  45              


Asn Pro Glu Ile Ala Arg Arg Leu Leu Leu Arg Gly Ala Asn Pro Asp 
    50                  55                  60                  


Leu Lys Asp Arg Thr Gly Phe Ala Val Ile His Asp Ala Ala Arg Ala 
65                  70                  75                  80  


Gly Phe Leu Asp Thr Leu Gln Thr Leu Leu Glu Phe Gln Ala Asp Val 
                85                  90                  95      


Asn Ile Glu Asp Asn Glu Gly Asn Leu Pro Leu His Leu Ala Ala Lys 
            100                 105                 110         


Glu Gly His Leu Arg Val Val Glu Phe Leu Val Lys His Thr Ala Ser 
        115                 120                 125             


Asn Val Gly His Arg Asn His Lys Gly Asp Thr Ala Cys Asp Leu Ala 
    130                 135                 140                 


Arg Leu Tyr Gly Arg Asn Glu Val Val Ser Leu Met Gln Ala Asn Gly 
145                 150                 155                 160 


Ala Gly Gly Ala Thr Asn Leu Gln 
                165             


<210>  195
<211>  1273
<212>  DNA
<213>  Homosapiens

<400>  195
ccttgagtct ccacacacac tcctcacaga gatctgtagc gtaggtacgt gacagctctg     60

cctacatctg acgtccggag tcattaacca ggaatgtatg tgtgtctgtg tgtctctctg    120

tggagtcgtc agaattcttc ataggggtta agctaaaaaa gcgaggcgag gagcccctct    180

ccaatggctc agttttgctg aataatcacg tgtgaatcga ggggcgggct tttggcaggc    240

agatcttact agtatttact accaagctct actccagatt aaccatccca gtccttctgt    300

cagtctccga tgccatcatg cagcctggtt aggagcaaag gaaaggggaa aaagaaaaac    360

gactaattca tcttttcctg atcgtcagga ccctaaagaa tggccgagcc ttgggggaac    420

gagttggcgt ccgcagctgc caggggggac ctagagcaac ttactagttt gttgcaaaat    480

aatgtaaacg tcaatgcaca aaatggattt ggaaggactg cgctgcaggt tatgaaactt    540

ggaaatcccg agattgccag gagactgcta cttagaggtg ctaatcccga tttgaaagac    600

cgaactggtt tcgctgtcat tcatgatgcg gccagagcag gtttcctgga cactttacag    660

actttgctgg agtttcaagc tgatgttaac atcgaggata atgaagggaa cctgcccttg    720

cacttggctg ccaaagaagg ccacctccgg gtggtggagt tcctggtgaa gcacacggcc    780

agcaatgtgg ggcatcggaa ccataagggg gacaccgcct gtgatttggc caggctctat    840

gggaggaatg aggttgttag cctgatgcag gcaaacgggg ctgggggagc cacaaatctt    900

caataaacgt ggggagggct cccccacgtt gcctctactt tatcaattaa ctgagtagct    960

ctcctgactt ttaatgtcat ttgttaaaat acagttctgt catatgttaa gcagctaaat   1020

tttctgaaac tgcataagtg aaaatcttac aacaggctta tgaatatatt taagcaacat   1080

ctttttaacc tgcaaaatct gttctaacat gtaattgcag ataactttga ctttcttctg   1140

aatattttat ctttccttgg cttttccctt gcttcccctt ttgccaatct caacacccaa   1200

gttgaagact ttgtttttaa aatggtttgt cctgatgctt ttgtctaatt aaaacacttt   1260

caaaacagga caa                                                      1273


<210>  196
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  196

Met Ala Glu Pro Trp Gly Asn Glu Leu Ala Ser Ala Ala Ala Arg Gly 
1               5                   10                  15      


Asp Leu Glu Gln Leu Thr Ser Leu Leu Gln Asn Asn Val Asn Val Asn 
            20                  25                  30          


Ala Gln Asn Gly Phe Gly Arg Thr Ala Leu Gln Val Met Lys Leu Gly 
        35                  40                  45              


Asn Pro Glu Ile Ala Arg Arg Leu Leu Leu Arg Gly Ala Asn Pro Asp 
    50                  55                  60                  


Leu Lys Asp Arg Thr Gly Phe Ala Val Ile His Asp Ala Ala Arg Ala 
65                  70                  75                  80  


Gly Phe Leu Asp Thr Leu Gln Thr Leu Leu Glu Phe Gln Ala Asp Val 
                85                  90                  95      


Asn Ile Glu Asp Asn Glu Gly Asn Leu Pro Leu His Leu Ala Ala Lys 
            100                 105                 110         


Glu Gly His Leu Arg Val Val Glu Phe Leu Val Lys His Thr Ala Ser 
        115                 120                 125             


Asn Val Gly His Arg Asn His Lys Gly Asp Thr Ala Cys Asp Leu Ala 
    130                 135                 140                 


Arg Leu Tyr Gly Arg Asn Glu Val Val Ser Leu Met Gln Ala Asn Gly 
145                 150                 155                 160 


Ala Gly Gly Ala Thr Asn Leu Gln 
                165             


<210>  197
<211>  905
<212>  DNA
<213>  Homosapiens

<400>  197
atggcttcac ctaaaggttt ttttaattac ttgacctatt ttcttgctgc tggtgctgtc     60

actttgggaa ttggtttctt tgctttggca tcagctttgt ggttcctgat ttgcaaacga    120

agagaaatat ttcaaaattc caaatttaaa gcaattgatg agagatgcag gcaaagacca    180

tcaatggcga agattaaatc tcattctcag tgtgttttta tttctcgaaa ttttcatact    240

gggagattcc aattacagga ggagcaaaga aaaaaggaag cagcacatat aaaagcaatt    300

aaagatcatt ctaaagatga accccaactt gcaacaaaaa atatcatttg tgatccctca    360

gagaccagct ccacaacaaa tcgcagcagt gttacattaa gcttatcaac attaccatct    420

gattcttatt acagccaaag tatagaagca gctgatgact ggttttctga tgattctcta    480

gtgaaaagga actctccaat gccttctctc ggggaacctc taatggaaaa agtattttca    540

tacctgtcaa ccatttcatt agaagagggt actgaaagtg tactgaatga cactttatga    600

ccatcaaaaa gatgactaca ttaagggaaa atgttcatga agaaacacag aggttgaaat    660

ataaaacctt caacataata ctgaatgact tttttctttt gaaaccttgt atacaatcag    720

cttctgagtc tcttaacatg tccatgctaa tattgctttt tttgttcttt accatagagc    780

ggctctactt cccttgctgg ttcttatttc tagaaacaaa attaggaaga actagagtga    840

tgtcatgaac attaagctta acttattgta tctcatccaa agacatatta aataaaatga    900

gtgta                                                                905


<210>  198
<211>  199
<212>  PRT
<213>  Homosapiens

<400>  198

Met Ala Ser Pro Lys Gly Phe Phe Asn Tyr Leu Thr Tyr Phe Leu Ala 
1               5                   10                  15      


Ala Gly Ala Val Thr Leu Gly Ile Gly Phe Phe Ala Leu Ala Ser Ala 
            20                  25                  30          


Leu Trp Phe Leu Ile Cys Lys Arg Arg Glu Ile Phe Gln Asn Ser Lys 
        35                  40                  45              


Phe Lys Ala Ile Asp Glu Arg Cys Arg Gln Arg Pro Ser Met Ala Lys 
    50                  55                  60                  


Ile Lys Ser His Ser Gln Cys Val Phe Ile Ser Arg Asn Phe His Thr 
65                  70                  75                  80  


Gly Arg Phe Gln Leu Gln Glu Glu Gln Arg Lys Lys Glu Ala Ala His 
                85                  90                  95      


Ile Lys Ala Ile Lys Asp His Ser Lys Asp Glu Pro Gln Leu Ala Thr 
            100                 105                 110         


Lys Asn Ile Ile Cys Asp Pro Ser Glu Thr Ser Ser Thr Thr Asn Arg 
        115                 120                 125             


Ser Ser Val Thr Leu Ser Leu Ser Thr Leu Pro Ser Asp Ser Tyr Tyr 
    130                 135                 140                 


Ser Gln Ser Ile Glu Ala Ala Asp Asp Trp Phe Ser Asp Asp Ser Leu 
145                 150                 155                 160 


Val Lys Arg Asn Ser Pro Met Pro Ser Leu Gly Glu Pro Leu Met Glu 
                165                 170                 175     


Lys Val Phe Ser Tyr Leu Ser Thr Ile Ser Leu Glu Glu Gly Thr Glu 
            180                 185                 190         


Ser Val Leu Asn Asp Thr Leu 
        195                 


<210>  199
<211>  497
<212>  DNA
<213>  Homosapiens

<400>  199
agaagaggaa aatatattta gacgaacaac cagaaatcta tttctattct ctggaagagc     60

ttgtataaga taagaaatac ttgaatcatg ggttttttta attacttgac ctattttctt    120

gctgctggtg ctgtcacttt gggaattggt ttctttgctt tggcatcagc tttgtggttc    180

ctgatttgca aacgaagaga aatatttcaa aattccaaat ttaaagcaat tgatgagaga    240

tgcaggcaaa gaccatcaat ggcgaagatt aaatctcatt ctcagtgtgt ttttatttct    300

cgaaattttc atactgggag attccaatta cagttttgaa ggctgagaag tccaagatca    360

agatgctgaa agatccggtt ctggtgaagg ccctcttcct gatttggaga tggccttttt    420

cttgctgtgt tttcagatgg cagggagcag agagagcaag agcgcacttt cacatctctt    480

cttataaagg cactaat                                                   497


<210>  200
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  200

Met Gly Phe Phe Asn Tyr Leu Thr Tyr Phe Leu Ala Ala Gly Ala Val 
1               5                   10                  15      


Thr Leu Gly Ile Gly Phe Phe Ala Leu Ala Ser Ala Leu Trp Phe Leu 
            20                  25                  30          


Ile Cys Lys Arg Arg Glu Ile Phe Gln Asn Ser Lys Phe Lys Ala Ile 
        35                  40                  45              


Asp Glu Arg Cys Arg Gln Arg Pro Ser Met Ala Lys Ile Lys Ser His 
    50                  55                  60                  


Ser Gln Cys Val Phe Ile Ser Arg Asn Phe His Thr Gly Arg Phe Gln 
65                  70                  75                  80  


Leu Gln Phe 
            


<210>  201
<211>  3139
<212>  DNA
<213>  Homosapiens

<400>  201
tgccgccgtc tcgctgaggc ggagtaggat gaggcccgcg gccgtggctc cggcgtcggc     60

gggggcagca gcagctgagg cagcagctga ggcagccgcg acggccgcgc ccccccccgc    120

tgacctggat taggcccagc agctccgtgg ccgccgccgc cccgcggggg ggcggggtgg    180

ggaagtgctt cgtctccccg cccccccccc cccatcgctg cctcgcagga ggcgaacgcc    240

gcgaccccag cggagcccgc ggcccagcct tgatccccca accccggggg ctggcatgag    300

cggcccctcg gcggcaccgt ggggcggtgg agtcgcctcc gcctgatccc cggcctgtcg    360

cccgacccca cctcgccaac cgaggcggac cgcggagtgt gcgaacgacc ccaccgctgc    420

tttctcctcc cccagatcac gcaccccagc tccggaagat ggggaactgc ctcaaatccc    480

ccacctcgga tgacatctcc ctgcttcacg agtctcagtc cgaccgggct agctttggcg    540

aggggacgga gccggatcag gagccgccgc cgccatatca ggaacaagtt ccagttccag    600

tctaccaccc aacacctagc cagactcggc tagcaactca gctgactgaa gaggaacaaa    660

ttaggatagc tcaaagaata ggtcttatac aacatctgcc taaaggagtt tatgaccctg    720

gaagagatgg atcagaaaaa aagatccggg agtgtgtgat ctgtatgatg gactttgttt    780

atggggaccc aattcgattt ctgccgtgca tgcacatcta tcacctggac tgtatagatg    840

actggttgat gagatccttc acgtgcccct cctgcatgga gccagttgat gcagcactgc    900

tttcatccta tgagactaat tgagccaggg tctcttatct gacttcaagt gaaccaccat    960

tttggtggtt ttgatctttt gtcactgagc ccaaagagcc agggattagg aattaagatc   1020

gtgcacaaaa gtttccttaa aattcctgga tggctgcaga tgttggggga aaaagtacgt   1080

gatattttag aaacttagtg ggaaaagtag gatggtattt ttatgtaaag ccttgaccca   1140

atgtttaaaa atataattgt atttagatct tgttattgct ccagtacata ggaattgtgt   1200

aaagtgttaa cagcagctgt atttgtttaa attgtgtgta ttgaagatta ggaaaaagat   1260

agtagttatt tttcctaaat gaaataactt tcttctcttc cccttcccca cccgaattct   1320

tttctgaagt tgctggcatt tgggtcaagg ttttattaaa agctacattt tataacactg   1380

gcacacacaa aaaagtagtt ttaagcttgt ttgcacagtt ctttttttcc attggaaatg   1440

gaattcattg ccttaggtct ttttaaatag tgtattatta tcgttggggc tggctctatg   1500

cttgaaaacc agtttattta taacctgtta taagtgctat attctgtttg cagttaggaa   1560

atgcagaatt caaagtgatc tcctagcttg taagcaaact gagatgcact atcccttttc   1620

tataaaaaat aagttaatgt gtcaagaaac caactctatt aaggtggggt ttaatattac   1680

cctttcctat gtgttttatc taattatttt ggttgttaat atggtgataa tggaaagtca   1740

agttaaattt taaatattaa gaattctgat ttattgagat tgaattatgc caccacgttt   1800

atgtaaaaat gaaggtggca ccgtggtgag acctaatgag aaatagttac tcagttgtaa   1860

aaattttgat ttattctctt tcttctgacc tccttgcctc ttgtcttgaa ccatagcaaa   1920

aggatactgc atctctcatt actgtagtgc tgaggttatt gaagttatac aaaacacatc   1980

tcagtctctg tttcttggaa aggtatctat tacatcctgc tagctgactg acaaaactaa   2040

gcagggagaa taaagataat tgtattttat gttttgcaca caaacgcaga atttgtataa   2100

ccatatgact tcatagttgt gatctcaaaa aagaaggaat ttctcctttg tttcttgcag   2160

ttaatgtaag aatactttaa atctctaagc ttctgaagtg ttagaggtag agatggtcta   2220

gtaaagatgt agtagtaatg ttttatccat ttagcatgtg tttatttttt catatgtact   2280

caaaggtgac ttattggttc acctcagtga tattacagct aaaaaaatca ttcattagca   2340

aaaggaaaag tggtctcaac ctaacatcag aagtgtttct tattattatt ttatattgag   2400

ttgaatattg aactctaaca gttttctaca tacaaaacac agtgtcatga aggttattca   2460

taattgcatt atagaggaat gtagtatgtc ataagtactt tgtaaagatt tgacattcaa   2520

ctgtagtatc catatgttgc ttaaatttcc ttatgagccc catgatggaa agacttaaag   2580

atgaatttga gaaaaattga aagaaattag attatcaggt tctgttaaat tgttacatgt   2640

atcttgctta aatttctgtt tattaattta tatccaccca agtacataaa gcaaatttgg   2700

aggaaacaac tgaagttgtg caatattttc tgataattgc tttttttatt cttgtgtttt   2760

ctacttaaac ataatgtctg tgtcatcaag tattatagtc agacttttct ttttttctag   2820

attgttaaaa ttggcaaatg aactttttta aaaatcatct tccatgttgc agttagtctt   2880

tcttttcatt acaagtcttt cacagaagtt tggtggtaat attgaaagaa ctagcattgg   2940

gcagaatgtg tcttttttag gcactttata ttctcaacat acaatgttaa gaaccatcaa   3000

ttttgacttt tactaagttg ttaaataaag ttataataca gctgtgaagg gctaaagtta   3060

gagttgatta cataagtaag tattccccat ataatctttt aaaaagttgt gtatgattat   3120

tttaaaatct ctctctcta                                                3139


<210>  202
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  202

Met Gly Asn Cys Leu Lys Ser Pro Thr Ser Asp Asp Ile Ser Leu Leu 
1               5                   10                  15      


His Glu Ser Gln Ser Asp Arg Ala Ser Phe Gly Glu Gly Thr Glu Pro 
            20                  25                  30          


Asp Gln Glu Pro Pro Pro Pro Tyr Gln Glu Gln Val Pro Val Pro Val 
        35                  40                  45              


Tyr His Pro Thr Pro Ser Gln Thr Arg Leu Ala Thr Gln Leu Thr Glu 
    50                  55                  60                  


Glu Glu Gln Ile Arg Ile Ala Gln Arg Ile Gly Leu Ile Gln His Leu 
65                  70                  75                  80  


Pro Lys Gly Val Tyr Asp Pro Gly Arg Asp Gly Ser Glu Lys Lys Ile 
                85                  90                  95      


Arg Glu Cys Val Ile Cys Met Met Asp Phe Val Tyr Gly Asp Pro Ile 
            100                 105                 110         


Arg Phe Leu Pro Cys Met His Ile Tyr His Leu Asp Cys Ile Asp Asp 
        115                 120                 125             


Trp Leu Met Arg Ser Phe Thr Cys Pro Ser Cys Met Glu Pro Val Asp 
    130                 135                 140                 


Ala Ala Leu Leu Ser Ser Tyr Glu Thr Asn 
145                 150                 


<210>  203
<211>  935
<212>  DNA
<213>  Homosapiens

<400>  203
tccgagaaaa caccaaatgg tggatgacac cagtgcagcg ggggggggcc cggaggccct     60

gggatgggga actgcggtgg cttccgcgga ggtttcggca gtggcatccg gggccggggt    120

cgcagccgta gacggggccg gggccgaggc cgcggagctc gcggaggcaa ggccgaggat    180

aaggagtgga tgcccgtcac caagctgggc tgcttggtga aggacatgaa gatcaagtcc    240

ctggaggaga tctatctctt ctccctgccc attaaggaat cagagatcat tgactttttc    300

ctgggggcct ctctcaagga tgaggttttg aagattatgc cagtgcagac gcagacccgt    360

gctggccagc gcaccaggtt caaggcgttt gttgctatcg gggactacaa tggccacgtc    420

ggtctgggtg ttaagtgctc caaggaggtg gccaccgcca tccatggggc catcatcctg    480

gccaagctct ccattgtccc cgtgcgcaga ggctactggg ggaacaagat tggcaagccc    540

cacaccgtcc cttgcaaggt gacaggccgc tgcggctctg cactggtgca cctcatccct    600

gtacccaggg gcactggcat tgtctccgca cctgtgccca agaagctgct catgatggct    660

ggtatcgatg actgctgcac ctcagcctgg ggctgcactg ccaccctggg caacttcgcc    720

aaggccacct ttgatgccat ttctaagacc tacagctacc tgacccccga cctctggaag    780

gagactgtat ttaccaagtc tcccgatcag gaattcactg accacctcat caaggcccac    840

gccagagtct ccgtgcagcg gacccaggct ccagctgtgg ctacaacata gggtttttag    900

acaaggaaaa taaagcgaat taagcgtaaa aaaaa                               935


<210>  204
<211>  275
<212>  PRT
<213>  Homosapiens

<400>  204

Met Gly Asn Cys Gly Gly Phe Arg Gly Gly Phe Gly Ser Gly Ile Arg 
1               5                   10                  15      


Gly Arg Gly Arg Ser Arg Arg Arg Gly Arg Gly Arg Gly Arg Gly Ala 
            20                  25                  30          


Arg Gly Gly Lys Ala Glu Asp Lys Glu Trp Met Pro Val Thr Lys Leu 
        35                  40                  45              


Gly Cys Leu Val Lys Asp Met Lys Ile Lys Ser Leu Glu Glu Ile Tyr 
    50                  55                  60                  


Leu Phe Ser Leu Pro Ile Lys Glu Ser Glu Ile Ile Asp Phe Phe Leu 
65                  70                  75                  80  


Gly Ala Ser Leu Lys Asp Glu Val Leu Lys Ile Met Pro Val Gln Thr 
                85                  90                  95      


Gln Thr Arg Ala Gly Gln Arg Thr Arg Phe Lys Ala Phe Val Ala Ile 
            100                 105                 110         


Gly Asp Tyr Asn Gly His Val Gly Leu Gly Val Lys Cys Ser Lys Glu 
        115                 120                 125             


Val Ala Thr Ala Ile His Gly Ala Ile Ile Leu Ala Lys Leu Ser Ile 
    130                 135                 140                 


Val Pro Val Arg Arg Gly Tyr Trp Gly Asn Lys Ile Gly Lys Pro His 
145                 150                 155                 160 


Thr Val Pro Cys Lys Val Thr Gly Arg Cys Gly Ser Ala Leu Val His 
                165                 170                 175     


Leu Ile Pro Val Pro Arg Gly Thr Gly Ile Val Ser Ala Pro Val Pro 
            180                 185                 190         


Lys Lys Leu Leu Met Met Ala Gly Ile Asp Asp Cys Cys Thr Ser Ala 
        195                 200                 205             


Trp Gly Cys Thr Ala Thr Leu Gly Asn Phe Ala Lys Ala Thr Phe Asp 
    210                 215                 220                 


Ala Ile Ser Lys Thr Tyr Ser Tyr Leu Thr Pro Asp Leu Trp Lys Glu 
225                 230                 235                 240 


Thr Val Phe Thr Lys Ser Pro Asp Gln Glu Phe Thr Asp His Leu Ile 
                245                 250                 255     


Lys Ala His Ala Arg Val Ser Val Gln Arg Thr Gln Ala Pro Ala Val 
            260                 265                 270         


Ala Thr Thr 
        275 


<210>  205
<211>  883
<212>  DNA
<213>  Homosapiens

<400>  205
tccgagaaaa caccaaatgg tggatgacac cagtgcagcg ggggggggcc cggaggccct     60

gggatgggga actgcggtgg cttccgcgga ggtttcggca gtggcatccg gggccggggt    120

cgcagccgta gacggggccg gggccgaggc cgcggagctc gcggaggcaa ggccgaggat    180

aaggagtgga tgcccgtcac caagctgggc tgcttggtga aggacatgaa gatcaagtcc    240

ctggaggaga tctatctctt ctccctgccc attaaggaat cagagatcat tgactttttc    300

ctgggggcct ctctcaagga tgaggttttg aagattatgc cagtgcagac gcagacccgt    360

gctggccagc gcaccaggtt caaggcgttt gttgctatcg gggactacaa tggccacgtc    420

ggtctgggtg ttaagtgctc caaggaggtg gccaccgcca tccatggggc catcatcctg    480

gccaagctct ccattgtccc cgtgcgcaga ggctactggg ggaacaagat tggcaagccc    540

cacaccgtcc cttgcaaggg gcactggcat tgtctccgca cctgtgccca agaagctgct    600

catgatggct ggtatcgatg actgctgcac ctcagcctgg ggctgcactg ccaccctggg    660

caacttcgcc aaggccacct ttgatgccat ttctaagacc tacagctacc tgacccccga    720

cctctggaag gagactgtat ttaccaagtc tcccgatcag gaattcactg accacctcat    780

caaggcccac gccagagtct ccgtgcagcg gacccaggct ccagctgtgg ctacaacata    840

gggtttttag acaaggaaaa taaagcgaat taagcgtaaa aaa                      883


<210>  206
<211>  185
<212>  PRT
<213>  Homosapiens

<400>  206

Met Gly Asn Cys Gly Gly Phe Arg Gly Gly Phe Gly Ser Gly Ile Arg 
1               5                   10                  15      


Gly Arg Gly Arg Ser Arg Arg Arg Gly Arg Gly Arg Gly Arg Gly Ala 
            20                  25                  30          


Arg Gly Gly Lys Ala Glu Asp Lys Glu Trp Met Pro Val Thr Lys Leu 
        35                  40                  45              


Gly Cys Leu Val Lys Asp Met Lys Ile Lys Ser Leu Glu Glu Ile Tyr 
    50                  55                  60                  


Leu Phe Ser Leu Pro Ile Lys Glu Ser Glu Ile Ile Asp Phe Phe Leu 
65                  70                  75                  80  


Gly Ala Ser Leu Lys Asp Glu Val Leu Lys Ile Met Pro Val Gln Thr 
                85                  90                  95      


Gln Thr Arg Ala Gly Gln Arg Thr Arg Phe Lys Ala Phe Val Ala Ile 
            100                 105                 110         


Gly Asp Tyr Asn Gly His Val Gly Leu Gly Val Lys Cys Ser Lys Glu 
        115                 120                 125             


Val Ala Thr Ala Ile His Gly Ala Ile Ile Leu Ala Lys Leu Ser Ile 
    130                 135                 140                 


Val Pro Val Arg Arg Gly Tyr Trp Gly Asn Lys Ile Gly Lys Pro His 
145                 150                 155                 160 


Thr Val Pro Cys Lys Gly His Trp His Cys Leu Arg Thr Cys Ala Gln 
                165                 170                 175     


Glu Ala Ala His Asp Gly Trp Tyr Arg 
            180                 185 


<210>  207
<211>  2872
<212>  DNA
<213>  Homosapiens

<400>  207
gggggaggga ggaggccttg gagaaggagg agggaaaaag gggctgtggg atttagtggc     60

tgggctgcac cccctggggg ggcagcagag cccaatgggc cagaagggcc acaaagactc    120

cctttaccct tgtggaggga ctcctgagag cagcctccat gaggccctgg accagtgcat    180

gaccgccctg gacctcttcc tcaccaacca gttctcagaa gcactcagct acctcaagcc    240

cagaaccaag gaaagcatgt accactcact gacatatgcc accatcctgg agatgcaggc    300

catgatgacc tttgaccctc aggacatcct gcttgccggc aacatgatga aggaggcaca    360

gatgctgtgt cagaggcacc ggaggaagtc ttctgtaaca gattccttca gcagcctggt    420

gaaccgcccc acgctgggcc aattcactga agaggaaatc cacgctgagg tctgctatgc    480

agagtgcctg ctgcagcgag cagccctgac cttcctgcag gacgagaaca tggtgagctt    540

catcaaaggc ggcatcaaag ttcgaaacag ctaccagacc tacaaggagc tggacagcct    600

tgttcagtcc tcacaatact gcaagggtga gaaccacccg cactttgaag gaggagtgaa    660

gcttggtgta ggggccttca acctgacact gtccatgctt cctactagga tcctgaggct    720

gttggagttt gtggggtttt caggaaacaa ggactatggg ctgctgcagc tggaggaggg    780

agcgtcaggg cacagcttcc gctctgtgct ctgtgtcatg ctcctgctgt gctaccacac    840

cttcctcacc ttcgtgctcg gtactgggaa cgtcaacatc gaggaggccg agaagctctt    900

gaagccctac ctgaaccggt accctaaggg tgccatcttc ctgttctttg cagggaggat    960

tgaagtcatt aaaggcaaca ttgatgcagc catccggcgt ttcgaggagt gctgtgaggc   1020

ccagcagcac tggaagcagt tccaccacat gtgctactgg gagctgatgt ggtgcttcac   1080

ctacaagggc cagtggaaga tgtcctactt ctacgccgac ctgctcagca aggagaactg   1140

ctggtccaag gccacctaca tttacatgaa ggccgcctac ctcagcatgt ttgggaagga   1200

ggaccacaag ccgttcgggg acgacgaagt ggaattattt cgagctgtgc caggcctgaa   1260

gctcaagatt gctgggaaat ctctacccac agagaagttt gccatccgga agtcccggcg   1320

ctacttctcc tccaacccta tctcgctgcc agtgcctgct ctggaaatga tgtacatctg   1380

gaacggctac gccgtgattg ggaagcagcc gaaactcacg gatgggatac ttgagattat   1440

cactaaggct gaagagatgc tggagaaagg cccagagaac gagtactcag tggatgacga   1500

gtgcttggtg aaattgttga aaggcctgtg tctgaaatac ctgggccgtg tccaggaggc   1560

cgaggagaat tttaggagca tctctgccaa tgaaaagaag attaaatatg accactactt   1620

gatcccaaac gccctgctgg agctggccct gctgcttatg gagcaagaca gaaacgaaga   1680

ggccatcaaa cttttggaat ctgccaagca aaactacaag aattactcca tggagtcaag   1740

gacacacttt cgaatccagg cagccacact ccaagccaag tcttccctag agaacagcag   1800

cagatccatg gtctcatcag tgtccttgta gctttgtgca gcagttccgg gctggaagac   1860

agagacagct ggacagagct cctgaaaaca tttcaaaata ccccctcccc ctgccctgcc   1920

ctgcctttgg ggtccaccgg cactccagtt ggatggcaca acatagtgta tccgtgcaga   1980

agccgagctg gcattttcac cagtgtagcc aagggccttt gccaagggca gagcaggtgg   2040

agccctctgc ctgccctatc acacatacgg gtacttgctt ttcactgtga tgtttaagag   2100

aatgtatgaa cagtttacat tttccttaga aatacattga tgggatcaca gttggcttta   2160

aaaaccaaca acaatcaacc acctgtaagt ctttgtcttc acctattatc atctggaggt   2220

aaatctcttt atatgatgat gccaaagggc aaattgcttt tcaaattcag caagttctca   2280

gcttgtgtga cggaaggtcc ttcagaggac ctgaggaatg cctgggagag gctaagcctc   2340

aggcttcaat gcttctgggg ttgggcatga ggatgtacac agacacccac taccttacta   2400

ctcacacttc atttcactcc ttttgtaaat ttccaattta aaaatcaagc acgtcttttt   2460

agtgagataa aatctgagct cttctgtaga aaaatcaatc tctaccagta gaaaatgcca   2520

gggcttgatg gaagagctgt gtagcccttt ctatgccaaa gccaggaaat ttggggggca   2580

ggaggaggtt ctcagaatcc agtctgtatc tttgctgtat gccaaactga aaccactggg   2640

aataatttat gaaacataaa aatcttctgt acttcactcc aaggtacatt tgcttactga   2700

cagcattttt gttaaaactg ttattcttga cctgttgtgt atgcgttaga ttcttcagtt   2760

aagagaaaag agatatttaa gtgataaaat ttatgccctt aagggatcgt gcatcatgta   2820

tttcaataaa atatgtgttg catgaatcct taggccaggc agaaagtctt ga           2872


<210>  208
<211>  578
<212>  PRT
<213>  Homosapiens

<400>  208

Met Gly Gln Lys Gly His Lys Asp Ser Leu Tyr Pro Cys Gly Gly Thr 
1               5                   10                  15      


Pro Glu Ser Ser Leu His Glu Ala Leu Asp Gln Cys Met Thr Ala Leu 
            20                  25                  30          


Asp Leu Phe Leu Thr Asn Gln Phe Ser Glu Ala Leu Ser Tyr Leu Lys 
        35                  40                  45              


Pro Arg Thr Lys Glu Ser Met Tyr His Ser Leu Thr Tyr Ala Thr Ile 
    50                  55                  60                  


Leu Glu Met Gln Ala Met Met Thr Phe Asp Pro Gln Asp Ile Leu Leu 
65                  70                  75                  80  


Ala Gly Asn Met Met Lys Glu Ala Gln Met Leu Cys Gln Arg His Arg 
                85                  90                  95      


Arg Lys Ser Ser Val Thr Asp Ser Phe Ser Ser Leu Val Asn Arg Pro 
            100                 105                 110         


Thr Leu Gly Gln Phe Thr Glu Glu Glu Ile His Ala Glu Val Cys Tyr 
        115                 120                 125             


Ala Glu Cys Leu Leu Gln Arg Ala Ala Leu Thr Phe Leu Gln Asp Glu 
    130                 135                 140                 


Asn Met Val Ser Phe Ile Lys Gly Gly Ile Lys Val Arg Asn Ser Tyr 
145                 150                 155                 160 


Gln Thr Tyr Lys Glu Leu Asp Ser Leu Val Gln Ser Ser Gln Tyr Cys 
                165                 170                 175     


Lys Gly Glu Asn His Pro His Phe Glu Gly Gly Val Lys Leu Gly Val 
            180                 185                 190         


Gly Ala Phe Asn Leu Thr Leu Ser Met Leu Pro Thr Arg Ile Leu Arg 
        195                 200                 205             


Leu Leu Glu Phe Val Gly Phe Ser Gly Asn Lys Asp Tyr Gly Leu Leu 
    210                 215                 220                 


Gln Leu Glu Glu Gly Ala Ser Gly His Ser Phe Arg Ser Val Leu Cys 
225                 230                 235                 240 


Val Met Leu Leu Leu Cys Tyr His Thr Phe Leu Thr Phe Val Leu Gly 
                245                 250                 255     


Thr Gly Asn Val Asn Ile Glu Glu Ala Glu Lys Leu Leu Lys Pro Tyr 
            260                 265                 270         


Leu Asn Arg Tyr Pro Lys Gly Ala Ile Phe Leu Phe Phe Ala Gly Arg 
        275                 280                 285             


Ile Glu Val Ile Lys Gly Asn Ile Asp Ala Ala Ile Arg Arg Phe Glu 
    290                 295                 300                 


Glu Cys Cys Glu Ala Gln Gln His Trp Lys Gln Phe His His Met Cys 
305                 310                 315                 320 


Tyr Trp Glu Leu Met Trp Cys Phe Thr Tyr Lys Gly Gln Trp Lys Met 
                325                 330                 335     


Ser Tyr Phe Tyr Ala Asp Leu Leu Ser Lys Glu Asn Cys Trp Ser Lys 
            340                 345                 350         


Ala Thr Tyr Ile Tyr Met Lys Ala Ala Tyr Leu Ser Met Phe Gly Lys 
        355                 360                 365             


Glu Asp His Lys Pro Phe Gly Asp Asp Glu Val Glu Leu Phe Arg Ala 
    370                 375                 380                 


Val Pro Gly Leu Lys Leu Lys Ile Ala Gly Lys Ser Leu Pro Thr Glu 
385                 390                 395                 400 


Lys Phe Ala Ile Arg Lys Ser Arg Arg Tyr Phe Ser Ser Asn Pro Ile 
                405                 410                 415     


Ser Leu Pro Val Pro Ala Leu Glu Met Met Tyr Ile Trp Asn Gly Tyr 
            420                 425                 430         


Ala Val Ile Gly Lys Gln Pro Lys Leu Thr Asp Gly Ile Leu Glu Ile 
        435                 440                 445             


Ile Thr Lys Ala Glu Glu Met Leu Glu Lys Gly Pro Glu Asn Glu Tyr 
    450                 455                 460                 


Ser Val Asp Asp Glu Cys Leu Val Lys Leu Leu Lys Gly Leu Cys Leu 
465                 470                 475                 480 


Lys Tyr Leu Gly Arg Val Gln Glu Ala Glu Glu Asn Phe Arg Ser Ile 
                485                 490                 495     


Ser Ala Asn Glu Lys Lys Ile Lys Tyr Asp His Tyr Leu Ile Pro Asn 
            500                 505                 510         


Ala Leu Leu Glu Leu Ala Leu Leu Leu Met Glu Gln Asp Arg Asn Glu 
        515                 520                 525             


Glu Ala Ile Lys Leu Leu Glu Ser Ala Lys Gln Asn Tyr Lys Asn Tyr 
    530                 535                 540                 


Ser Met Glu Ser Arg Thr His Phe Arg Ile Gln Ala Ala Thr Leu Gln 
545                 550                 555                 560 


Ala Lys Ser Ser Leu Glu Asn Ser Ser Arg Ser Met Val Ser Ser Val 
                565                 570                 575     


Ser Leu 
        


<210>  209
<211>  2789
<212>  DNA
<213>  Homosapiens

<400>  209
ccatggcctt tctgaccacc tggaaggagg cggcctccgg gaaaagcgac cgcaggactc     60

ctgagagcag cctccatgag gccctggacc agtgcatgac cgccctggac ctcttcctca    120

ccaaccagtt ctcagaagca ctcagctacc tcaagcccag aaccaaggaa agcatgtacc    180

actcactgac atatgccacc atcctggaga tgcaggccat gatgaccttt gaccctcagg    240

acatcctgct tgccggcaac atgatgaagg aggcacagat gctgtgtcag aggcaccgga    300

ggaagtcttc tgtaacagat tccttcagca gcctggtgaa ccgccccacg ctgggccaat    360

tcactgaaga ggaaatccac gctgaggtct gctatgcaga gtgcctgctg cagcgagcag    420

ccctgacctt cctgcaggac gagaacatgg tgagcttcat caaaggcggc atcaaagttc    480

gaaacagcta ccagacctac aaggagctgg acagccttgt tcagtcctca caatactgca    540

agggtgagaa ccacccgcac tttgaaggag gagtgaagct tggtgtaggg gccttcaacc    600

tgacactgtc catgcttcct actaggatcc tgaggctgtt ggagtttgtg gggttttcag    660

gaaacaagga ctatgggctg ctgcagctgg aggagggagc gtcagggcac agcttccgct    720

ctgtgctctg tgtcatgctc ctgctgtgct accacacctt cctcaccttc gtgctcggta    780

ctgggaacgt caacatcgag gaggccgaga agctcttgaa gccctacctg aaccggtacc    840

ctaagggtgc catcttcctg ttctttgcag ggaggattga agtcattaaa ggcaacattg    900

atgcagccat ccggcgtttc gaggagtgct gtgaggccca gcagcactgg aagcagttcc    960

accacatgtg ctactgggag ctgatgtggt gcttcaccta caagggccag tggaagatgt   1020

cctacttcta cgccgacctg ctcagcaagg agaactgctg gtccaaggcc acctacattt   1080

acatgaaggc cgcctacctc agcatgtttg ggaaggagga ccacaagccg ttcggggacg   1140

acgaagtgga attatttcga gctgtgccag gcctgaagct caagattgct gggaaatctc   1200

tacccacaga gaagtttgcc atccggaagt cccggcgcta cttctcctcc aaccctatct   1260

cgctgccagt gcctgctctg gaaatgatgt acatctggaa cggctacgcc gtgattggga   1320

agcagccgaa actcacggat gggatacttg agattatcac taaggctgaa gagatgctgg   1380

agaaaggccc agagaacgag tactcagtgg atgacgagtg cttggtgaaa ttgttgaaag   1440

gcctgtgtct gaaatacctg ggccgtgtcc aggaggccga ggagaatttt aggagcatct   1500

ctgccaatga aaagaagatt aaatatgacc actacttgat cccaaacgcc ctgctggagc   1560

tggccctgct gcttatggag caagacagaa acgaagaggc catcaaactt ttggaatctg   1620

ccaagcaaaa ctacaagaat tactccatgg agtcaaggac acactttcga atccaggcag   1680

ccacactcca agccaagtct tccctagaga acagcagcag atccatggtc tcatcagtgt   1740

ccttgtagct ttgtgcagca gttccgggct ggaagacaga gacagctgga cagagctcct   1800

gaaaacattt caaaataccc cctccccctg ccctgccctg cctttggggt ccaccggcac   1860

tccagttgga tggcacaaca tagtgtatcc gtgcagaagc cgagctggca ttttcaccag   1920

tgtagccaag ggcctttgcc aagggcagag caggtggagc cctctgcctg ccctatcaca   1980

catacgggta cttgcttttc actgtgatgt ttaagagaat gtatgaacag tttacatttt   2040

ccttagaaat acattgatgg gatcacagtt ggctttaaaa accaacaaca atcaaccacc   2100

tgtaagtctt tgtcttcacc tattatcatc tggaggtaaa tctctttata tgatgatgcc   2160

aaagggcaaa ttgcttttca aattcagcaa gttctcagct tgtgtgacgg aaggtccttc   2220

agaggacctg aggaatgcct gggagaggct aagcctcagg cttcaatgct tctggggttg   2280

ggcatgagga tgtacacaga cacccactac cttactactc acacttcatt tcactccttt   2340

tgtaaatttc caatttaaaa atcaagcacg tctttttagt gagataaaat ctgagctctt   2400

ctgtagaaaa atcaatctct accagtagaa aatgccaggg cttgatggaa gagctgtgta   2460

gccctttcta tgccaaagcc aggaaatttg gggggcagga ggaggttctc agaatccagt   2520

ctgtatcttt gctgtatgcc aaactgaaac cactgggaat aatttatgaa acataaaaat   2580

cttctgtact tcactccaag gtacatttgc ttactgacag catttttgtt aaaactgtta   2640

ttcttgacct gttgtgtatg cgttagattc ttcagttaag agaaaagaga tatttaagtg   2700

ataaaattta tgcccttaag ggatcgtgca tcatgtattt caataaaata tgtgttgcat   2760

gaatccttag gccaggcaga aagtcttga                                     2789


<210>  210
<211>  581
<212>  PRT
<213>  Homosapiens

<400>  210

Met Ala Phe Leu Thr Thr Trp Lys Glu Ala Ala Ser Gly Lys Ser Asp 
1               5                   10                  15      


Arg Arg Thr Pro Glu Ser Ser Leu His Glu Ala Leu Asp Gln Cys Met 
            20                  25                  30          


Thr Ala Leu Asp Leu Phe Leu Thr Asn Gln Phe Ser Glu Ala Leu Ser 
        35                  40                  45              


Tyr Leu Lys Pro Arg Thr Lys Glu Ser Met Tyr His Ser Leu Thr Tyr 
    50                  55                  60                  


Ala Thr Ile Leu Glu Met Gln Ala Met Met Thr Phe Asp Pro Gln Asp 
65                  70                  75                  80  


Ile Leu Leu Ala Gly Asn Met Met Lys Glu Ala Gln Met Leu Cys Gln 
                85                  90                  95      


Arg His Arg Arg Lys Ser Ser Val Thr Asp Ser Phe Ser Ser Leu Val 
            100                 105                 110         


Asn Arg Pro Thr Leu Gly Gln Phe Thr Glu Glu Glu Ile His Ala Glu 
        115                 120                 125             


Val Cys Tyr Ala Glu Cys Leu Leu Gln Arg Ala Ala Leu Thr Phe Leu 
    130                 135                 140                 


Gln Asp Glu Asn Met Val Ser Phe Ile Lys Gly Gly Ile Lys Val Arg 
145                 150                 155                 160 


Asn Ser Tyr Gln Thr Tyr Lys Glu Leu Asp Ser Leu Val Gln Ser Ser 
                165                 170                 175     


Gln Tyr Cys Lys Gly Glu Asn His Pro His Phe Glu Gly Gly Val Lys 
            180                 185                 190         


Leu Gly Val Gly Ala Phe Asn Leu Thr Leu Ser Met Leu Pro Thr Arg 
        195                 200                 205             


Ile Leu Arg Leu Leu Glu Phe Val Gly Phe Ser Gly Asn Lys Asp Tyr 
    210                 215                 220                 


Gly Leu Leu Gln Leu Glu Glu Gly Ala Ser Gly His Ser Phe Arg Ser 
225                 230                 235                 240 


Val Leu Cys Val Met Leu Leu Leu Cys Tyr His Thr Phe Leu Thr Phe 
                245                 250                 255     


Val Leu Gly Thr Gly Asn Val Asn Ile Glu Glu Ala Glu Lys Leu Leu 
            260                 265                 270         


Lys Pro Tyr Leu Asn Arg Tyr Pro Lys Gly Ala Ile Phe Leu Phe Phe 
        275                 280                 285             


Ala Gly Arg Ile Glu Val Ile Lys Gly Asn Ile Asp Ala Ala Ile Arg 
    290                 295                 300                 


Arg Phe Glu Glu Cys Cys Glu Ala Gln Gln His Trp Lys Gln Phe His 
305                 310                 315                 320 


His Met Cys Tyr Trp Glu Leu Met Trp Cys Phe Thr Tyr Lys Gly Gln 
                325                 330                 335     


Trp Lys Met Ser Tyr Phe Tyr Ala Asp Leu Leu Ser Lys Glu Asn Cys 
            340                 345                 350         


Trp Ser Lys Ala Thr Tyr Ile Tyr Met Lys Ala Ala Tyr Leu Ser Met 
        355                 360                 365             


Phe Gly Lys Glu Asp His Lys Pro Phe Gly Asp Asp Glu Val Glu Leu 
    370                 375                 380                 


Phe Arg Ala Val Pro Gly Leu Lys Leu Lys Ile Ala Gly Lys Ser Leu 
385                 390                 395                 400 


Pro Thr Glu Lys Phe Ala Ile Arg Lys Ser Arg Arg Tyr Phe Ser Ser 
                405                 410                 415     


Asn Pro Ile Ser Leu Pro Val Pro Ala Leu Glu Met Met Tyr Ile Trp 
            420                 425                 430         


Asn Gly Tyr Ala Val Ile Gly Lys Gln Pro Lys Leu Thr Asp Gly Ile 
        435                 440                 445             


Leu Glu Ile Ile Thr Lys Ala Glu Glu Met Leu Glu Lys Gly Pro Glu 
    450                 455                 460                 


Asn Glu Tyr Ser Val Asp Asp Glu Cys Leu Val Lys Leu Leu Lys Gly 
465                 470                 475                 480 


Leu Cys Leu Lys Tyr Leu Gly Arg Val Gln Glu Ala Glu Glu Asn Phe 
                485                 490                 495     


Arg Ser Ile Ser Ala Asn Glu Lys Lys Ile Lys Tyr Asp His Tyr Leu 
            500                 505                 510         


Ile Pro Asn Ala Leu Leu Glu Leu Ala Leu Leu Leu Met Glu Gln Asp 
        515                 520                 525             


Arg Asn Glu Glu Ala Ile Lys Leu Leu Glu Ser Ala Lys Gln Asn Tyr 
    530                 535                 540                 


Lys Asn Tyr Ser Met Glu Ser Arg Thr His Phe Arg Ile Gln Ala Ala 
545                 550                 555                 560 


Thr Leu Gln Ala Lys Ser Ser Leu Glu Asn Ser Ser Arg Ser Met Val 
                565                 570                 575     


Ser Ser Val Ser Leu 
            580     


<210>  211
<211>  1864
<212>  DNA
<213>  Homosapiens

<400>  211
cccggctcgg ggttgcggcg gcagcacctg ggccgcgatt ggcgtccggc tggggcagcg     60

ccgcccgcgc ccctcggcga tgacctcggc tggcggcgcc ccaggagccc tgcccgcggg    120

gactcctgag agcagcctcc atgaggccct ggaccagtgc atgaccgccc tggacctctt    180

cctcaccaac cagttctcag aagcactcag ctacctcaag cccagaacca aggaaagcat    240

gtaccactca ctgacatatg ccaccatcct ggagatgcag gccatgatga cctttgaccc    300

tcaggacatc ctgcttgccg gcaacatgat gaaggaggca cagatgctgt gtcagaggca    360

ccggaggaag tcttctgtaa cagattcctt cagcagcctg gtgaaccgcc ccacgctggg    420

ccaattcact gaagaggaaa tccacgctga ggtctgctat gcagagtgcc tgctgcagcg    480

agcagccctg accttcctgc agggttcctc acacggaggg gcagtcaggc ccagagcctt    540

gcatgatccc tctcacgcct gcagctgccc acctgggcca ggccgtcagc atcttttcct    600

cctgcaggac gagaacatgg tgagcttcat caaaggcggc atcaaagttc gaaacagcta    660

ccagacctac aaggagctgg acagccttgt tcagtcctca caatactgca agggtgagaa    720

ccacccgcac tttgaaggag gagtgaagct tggtgtaggg gccttcaacc tgacactgtc    780

catgcttcct actaggatcc tgaggctgtt ggagtttgtg gggttttcag gaaacaagga    840

ctatgggctg ctgcagctgg aggagggagc gtcagggcac agcttccgct ctgtgctctg    900

tgtcatgctc ctgctgtgct accacacctt cctcaccttc gtgctcggta ctgggaacgt    960

caacatcgag gaggccgaga agctcttgaa gccctacctg aaccggtacc ctaagggtgc   1020

catcttcctg ttctttgcag ggaggattga agtcattaaa ggcaacattg atgcagccat   1080

ccggcgtttc gaggagtgct gtgaggccca gcagcactgg aagcagttcc accacatgtg   1140

ctactgggag ctgatgtggt gcttcaccta caagggccag tggaagatgt cctacttcta   1200

cgccgacctg ctcagcaagg agaactgctg gtccaaggcc acctacattt acatgaaggc   1260

cgcctacctc agcatgtttg ggaaggagga ccacaagccg ttcggggacg acgaagtgga   1320

attatttcgg tgggtcccac atcgtgctcc cactgtgtag gccactccca ccgtgtaggc   1380

cgctatggac agaccagcca ggccaccctg agctgtgggc actggggagg gaggagtagg   1440

gtggctccct gcccccaccc gcggactgcc ccccctgcgt gtcctcccct cccatcacca   1500

ccccatgctg ctgctgctgg tggttggagc cctttgactt tcttcagagg ctttctttca   1560

cagaaatggt tttgctaata tcgtcttcct ccgagtctct ttcatgtgga cagtaggaca   1620

gatgtggctc caaggtccag ggagggaagg tctttcactc tgctgagtta acctgagaca   1680

ctcagagaag cacagtagag agctgacagt cggaatcgaa caaacaagag taaacccagc   1740

ctctgcttgt tcttagctgt gtcaccttgg acaacttcag catctgtaaa atgggaacaa   1800

caacctccac ctcgcagcac tgttttgcaa atcaactaga taataaatgt taagagcctg   1860

gcgc                                                                1864


<210>  212
<211>  426
<212>  PRT
<213>  Homosapiens

<400>  212

Met Thr Ser Ala Gly Gly Ala Pro Gly Ala Leu Pro Ala Gly Thr Pro 
1               5                   10                  15      


Glu Ser Ser Leu His Glu Ala Leu Asp Gln Cys Met Thr Ala Leu Asp 
            20                  25                  30          


Leu Phe Leu Thr Asn Gln Phe Ser Glu Ala Leu Ser Tyr Leu Lys Pro 
        35                  40                  45              


Arg Thr Lys Glu Ser Met Tyr His Ser Leu Thr Tyr Ala Thr Ile Leu 
    50                  55                  60                  


Glu Met Gln Ala Met Met Thr Phe Asp Pro Gln Asp Ile Leu Leu Ala 
65                  70                  75                  80  


Gly Asn Met Met Lys Glu Ala Gln Met Leu Cys Gln Arg His Arg Arg 
                85                  90                  95      


Lys Ser Ser Val Thr Asp Ser Phe Ser Ser Leu Val Asn Arg Pro Thr 
            100                 105                 110         


Leu Gly Gln Phe Thr Glu Glu Glu Ile His Ala Glu Val Cys Tyr Ala 
        115                 120                 125             


Glu Cys Leu Leu Gln Arg Ala Ala Leu Thr Phe Leu Gln Gly Ser Ser 
    130                 135                 140                 


His Gly Gly Ala Val Arg Pro Arg Ala Leu His Asp Pro Ser His Ala 
145                 150                 155                 160 


Cys Ser Cys Pro Pro Gly Pro Gly Arg Gln His Leu Phe Leu Leu Gln 
                165                 170                 175     


Asp Glu Asn Met Val Ser Phe Ile Lys Gly Gly Ile Lys Val Arg Asn 
            180                 185                 190         


Ser Tyr Gln Thr Tyr Lys Glu Leu Asp Ser Leu Val Gln Ser Ser Gln 
        195                 200                 205             


Tyr Cys Lys Gly Glu Asn His Pro His Phe Glu Gly Gly Val Lys Leu 
    210                 215                 220                 


Gly Val Gly Ala Phe Asn Leu Thr Leu Ser Met Leu Pro Thr Arg Ile 
225                 230                 235                 240 


Leu Arg Leu Leu Glu Phe Val Gly Phe Ser Gly Asn Lys Asp Tyr Gly 
                245                 250                 255     


Leu Leu Gln Leu Glu Glu Gly Ala Ser Gly His Ser Phe Arg Ser Val 
            260                 265                 270         


Leu Cys Val Met Leu Leu Leu Cys Tyr His Thr Phe Leu Thr Phe Val 
        275                 280                 285             


Leu Gly Thr Gly Asn Val Asn Ile Glu Glu Ala Glu Lys Leu Leu Lys 
    290                 295                 300                 


Pro Tyr Leu Asn Arg Tyr Pro Lys Gly Ala Ile Phe Leu Phe Phe Ala 
305                 310                 315                 320 


Gly Arg Ile Glu Val Ile Lys Gly Asn Ile Asp Ala Ala Ile Arg Arg 
                325                 330                 335     


Phe Glu Glu Cys Cys Glu Ala Gln Gln His Trp Lys Gln Phe His His 
            340                 345                 350         


Met Cys Tyr Trp Glu Leu Met Trp Cys Phe Thr Tyr Lys Gly Gln Trp 
        355                 360                 365             


Lys Met Ser Tyr Phe Tyr Ala Asp Leu Leu Ser Lys Glu Asn Cys Trp 
    370                 375                 380                 


Ser Lys Ala Thr Tyr Ile Tyr Met Lys Ala Ala Tyr Leu Ser Met Phe 
385                 390                 395                 400 


Gly Lys Glu Asp His Lys Pro Phe Gly Asp Asp Glu Val Glu Leu Phe 
                405                 410                 415     


Arg Trp Val Pro His Arg Ala Pro Thr Val 
            420                 425     


<210>  213
<211>  1800
<212>  DNA
<213>  Homosapiens

<400>  213
ggcagggcac agcagggcag gagtgtgttt gatgtgtcct gggaaccgcc ctgaggccgt     60

cgtgtggctg gagtgctgca ggtgtcaagg aaattgtagg agatgtctcc tgagtgtgat    120

ggaatataac cagatttcca gaaggaactg acatgatctg acttaaaaag agctgtgcca    180

ggcctgaagc tcaagattgc tgggaaatct ctacccacag agaagtttgc catccggaag    240

tcccggcgct acttctcctc caaccctatc tcgctgccag tgcctgctct ggaaatgatg    300

tacatctgga acggctacgc cgtgattggg aagcagccga aactcacgga tgggatactt    360

gagattatca ctaaggctga agagatgctg gagaaaggcc cagagaacga gtactcagtg    420

gatgacgagt gcttggtgaa attgttgaaa ggcctgtgtc tgaaatacct gggccgtgtc    480

caggaggccg aggagaattt taggagcatc tctgccaatg aaaagaagat taaatatgac    540

cactacttga tcccaaacgc cctgctggag ctggccctgc tgcttatgga gcaagacaga    600

aacgaagagg ccatcaaact tttggaatct gccaagcaaa actacaagaa ttactccatg    660

gagtcaagga cacactttcg aatccaggca gccacactcc aagccaagtc ttccctagag    720

aacagcagca gatccatggt ctcatcagtg tccttgtagc tttgtgcagc agttccgggc    780

tggaagacag agacagctgg acagagctcc tgaaaacatt tcaaaatacc ccctccccct    840

gccctgccct gcctttgggg tccaccggca ctccagttgg atggcacaac atagtgtatc    900

cgtgcagaag ccgagctggc attttcacca gtgtagccaa gggcctttgc caagggcaga    960

gcaggtggag ccctctgcct gccctatcac acatacgggt acttgctttt cactgtgatg   1020

tttaagagaa tgtatgaaca gtttacattt tccttagaaa tacattgatg ggatcacagt   1080

tggctttaaa aaccaacaac aatcaaccac ctgtaagtct ttgtcttcac ctattatcat   1140

ctggaggtaa atctctttat atgatgatgc caaagggcaa attgcttttc aaattcagca   1200

agttctcagc ttgtgtgacg gaaggtcctt cagaggacct gaggaatgcc tgggagaggc   1260

taagcctcag gcttcaatgc ttctggggtt gggcatgagg atgtacacag acacccacta   1320

ccttactact cacacttcat ttcactcctt ttgtaaattt ccaatttaaa aatcaagcac   1380

gtctttttag tgagataaaa tctgagctct tctgtagaaa aatcaatctc taccagtaga   1440

aaatgccagg gcttgatgga agagctgtgt agccctttct atgccaaagc caggaaattt   1500

ggggggcagg aggaggttct cagaatccag tctgtatctt tgctgtatgc caaactgaaa   1560

ccactgggaa taatttatga aacataaaaa tcttctgtac ttcactccaa ggtacatttg   1620

cttactgaca gcatttttgt taaaactgtt attcttgacc tgttgtgtat gcgttagatt   1680

cttcagttaa gagaaaagag atatttaagt gataaaattt atgcccttaa gggatcgtgc   1740

atcatgtatt tcaataaaat atgtgttgca tgaatcctta ggccaggcag aaagtcttga   1800


<210>  214
<211>  153
<212>  PRT
<213>  Homosapiens

<400>  214

Met Tyr Ile Trp Asn Gly Tyr Ala Val Ile Gly Lys Gln Pro Lys Leu 
1               5                   10                  15      


Thr Asp Gly Ile Leu Glu Ile Ile Thr Lys Ala Glu Glu Met Leu Glu 
            20                  25                  30          


Lys Gly Pro Glu Asn Glu Tyr Ser Val Asp Asp Glu Cys Leu Val Lys 
        35                  40                  45              


Leu Leu Lys Gly Leu Cys Leu Lys Tyr Leu Gly Arg Val Gln Glu Ala 
    50                  55                  60                  


Glu Glu Asn Phe Arg Ser Ile Ser Ala Asn Glu Lys Lys Ile Lys Tyr 
65                  70                  75                  80  


Asp His Tyr Leu Ile Pro Asn Ala Leu Leu Glu Leu Ala Leu Leu Leu 
                85                  90                  95      


Met Glu Gln Asp Arg Asn Glu Glu Ala Ile Lys Leu Leu Glu Ser Ala 
            100                 105                 110         


Lys Gln Asn Tyr Lys Asn Tyr Ser Met Glu Ser Arg Thr His Phe Arg 
        115                 120                 125             


Ile Gln Ala Ala Thr Leu Gln Ala Lys Ser Ser Leu Glu Asn Ser Ser 
    130                 135                 140                 


Arg Ser Met Val Ser Ser Val Ser Leu 
145                 150             


<210>  215
<211>  1929
<212>  DNA
<213>  Homosapiens

<400>  215
gcagtcacat ggcaggccgt tagggcagag ggagctgggc agggcacagc agggcaggag     60

tgtgtttgat gtgtcctggg aaccgccctg aggccgtcgt gtggctggag tgctgcaggt    120

gtcaaggaaa ttgtaggaga tgtctcctga gtgtgatgga atataaccag atttccagaa    180

ggaactgaca tgatctgact taaaaaggcc acctacattt acatgaaggc cgcctacctc    240

agcatgtttg ggaaggagga ccacaagccg ttcggggacg acgaagtgga attatttcga    300

gctgtgccag gcctgaagct caagattgct gggaaatctc tacccacaga gaagtttgcc    360

atccggaagt cccggcgcta cttctcctcc aaccctatct cgctgccagt gcctgctctg    420

gaaatgatgt acatctggaa cggctacgcc gtgattggga agcagccgaa actcacggat    480

gggatacttg agattatcac taaggctgaa gagatgctgg agaaaggccc agagaacgag    540

tactcagtgg atgacgagtg cttggtgaaa ttgttgaaag gcctgtgtct gaaatacctg    600

ggccgtgtcc aggaggccga ggagaatttt aggagcatct ctgccaatga aaagaagatt    660

aaatatgacc actacttgat cccaaacgcc ctgctggagc tggccctgct gcttatggag    720

caagacagaa acgaagaggc catcaaactt ttggaatctg ccaagcaaaa ctacaagaat    780

tactccatgg agtcaaggac acactttcga atccaggcag ccacactcca agccaagtct    840

tccctagaga acagcagcag atccatggtc tcatcagtgt ccttgtagct ttgtgcagca    900

gttccgggct ggaagacaga gacagctgga cagagctcct gaaaacattt caaaataccc    960

cctccccctg ccctgccctg cctttggggt ccaccggcac tccagttgga tggcacaaca   1020

tagtgtatcc gtgcagaagc cgagctggca ttttcaccag tgtagccaag ggcctttgcc   1080

aagggcagag caggtggagc cctctgcctg ccctatcaca catacgggta cttgcttttc   1140

actgtgatgt ttaagagaat gtatgaacag tttacatttt ccttagaaat acattgatgg   1200

gatcacagtt ggctttaaaa accaacaaca atcaaccacc tgtaagtctt tgtcttcacc   1260

tattatcatc tggaggtaaa tctctttata tgatgatgcc aaagggcaaa ttgcttttca   1320

aattcagcaa gttctcagct tgtgtgacgg aaggtccttc agaggacctg aggaatgcct   1380

gggagaggct aagcctcagg cttcaatgct tctggggttg ggcatgagga tgtacacaga   1440

cacccactac cttactactc acacttcatt tcactccttt tgtaaatttc caatttaaaa   1500

atcaagcacg tctttttagt gagataaaat ctgagctctt ctgtagaaaa atcaatctct   1560

accagtagaa aatgccaggg cttgatggaa gagctgtgta gccctttcta tgccaaagcc   1620

aggaaatttg gggggcagga ggaggttctc agaatccagt ctgtatcttt gctgtatgcc   1680

aaactgaaac cactgggaat aatttatgaa acataaaaat cttctgtact tcactccaag   1740

gtacatttgc ttactgacag catttttgtt aaaactgtta ttcttgacct gttgtgtatg   1800

cgttagattc ttcagttaag agaaaagaga tatttaagtg ataaaattta tgcccttaag   1860

ggatcgtgca tcatgtattt caataaaata tgtgttgcat gaatccttag gccaggcaga   1920

aagtcttga                                                           1929


<210>  216
<211>  221
<212>  PRT
<213>  Homosapiens

<400>  216

Met Lys Ala Ala Tyr Leu Ser Met Phe Gly Lys Glu Asp His Lys Pro 
1               5                   10                  15      


Phe Gly Asp Asp Glu Val Glu Leu Phe Arg Ala Val Pro Gly Leu Lys 
            20                  25                  30          


Leu Lys Ile Ala Gly Lys Ser Leu Pro Thr Glu Lys Phe Ala Ile Arg 
        35                  40                  45              


Lys Ser Arg Arg Tyr Phe Ser Ser Asn Pro Ile Ser Leu Pro Val Pro 
    50                  55                  60                  


Ala Leu Glu Met Met Tyr Ile Trp Asn Gly Tyr Ala Val Ile Gly Lys 
65                  70                  75                  80  


Gln Pro Lys Leu Thr Asp Gly Ile Leu Glu Ile Ile Thr Lys Ala Glu 
                85                  90                  95      


Glu Met Leu Glu Lys Gly Pro Glu Asn Glu Tyr Ser Val Asp Asp Glu 
            100                 105                 110         


Cys Leu Val Lys Leu Leu Lys Gly Leu Cys Leu Lys Tyr Leu Gly Arg 
        115                 120                 125             


Val Gln Glu Ala Glu Glu Asn Phe Arg Ser Ile Ser Ala Asn Glu Lys 
    130                 135                 140                 


Lys Ile Lys Tyr Asp His Tyr Leu Ile Pro Asn Ala Leu Leu Glu Leu 
145                 150                 155                 160 


Ala Leu Leu Leu Met Glu Gln Asp Arg Asn Glu Glu Ala Ile Lys Leu 
                165                 170                 175     


Leu Glu Ser Ala Lys Gln Asn Tyr Lys Asn Tyr Ser Met Glu Ser Arg 
            180                 185                 190         


Thr His Phe Arg Ile Gln Ala Ala Thr Leu Gln Ala Lys Ser Ser Leu 
        195                 200                 205             


Glu Asn Ser Ser Arg Ser Met Val Ser Ser Val Ser Leu 
    210                 215                 220     


<210>  217
<211>  2248
<212>  DNA
<213>  Homosapiens

<400>  217
ggggacagag aactaagtct tgttcctgca tggagtgggg gaaggtttcc tacgggaggg     60

gacactgtcc atgcttccta ctaggatcct gaggctgttg gagtttgtgg ggttttcagg    120

aaacaaggac tatgggctgc tgcagctgga ggagggagcg tcagggcaca gcttccgctc    180

tgtgctctgt gtcatgctcc tgctgtgcta ccacaccttc ctcaccttcg tgctcggtac    240

tgggaacgtc aacatcgagg aggccgagaa gctcttgaag ccctacctga accggtaccc    300

taagggtgcc atcttcctgt tctttgcagg gaggattgaa gtcattaaag gcaacattga    360

tgcagccatc cggcgtttcg aggagtgctg tgaggcccag cagcactgga agcagttcca    420

ccacatgtgc tactgggagc tgatgtggtg cttcacctac aagggccagt ggaagatgtc    480

ctacttctac gccgacctgc tcagcaagga gaactgctgg tccaaggcca cctacattta    540

catgaaggcc gcctacctca gcatgtttgg gaaggaggac cacaagccgt tcggggacga    600

cgaagtggaa ttatttcgag ctgtgccagg cctgaagctc aagattgctg ggaaatctct    660

acccacagag aagtttgcca tccggaagtc ccggcgctac ttctcctcca accctatctc    720

gctgccagtg cctgctctgg aaatgatgta catctggaac ggctacgccg tgattgggaa    780

gcagccgaaa ctcacggatg ggatacttga gattatcact aaggctgaag agatgctgga    840

gaaaggccca gagaacgagt actcagtgga tgacgagtgc ttggtgaaat tgttgaaagg    900

cctgtgtctg aaatacctgg gccgtgtcca ggaggccgag gagaatttta ggagcatctc    960

tgccaatgaa aagaagatta aatatgacca ctacttgatc ccaaacgccc tgctggagct   1020

ggccctgctg cttatggagc aagacagaaa cgaagaggcc atcaaacttt tggaatctgc   1080

caagcaaaac tacaagaatt actccatgga gtcaaggaca cactttcgaa tccaggcagc   1140

cacactccaa gccaagtctt ccctagagaa cagcagcaga tccatggtct catcagtgtc   1200

cttgtagctt tgtgcagcag ttccgggctg gaagacagag acagctggac agagctcctg   1260

aaaacatttc aaaatacccc ctccccctgc cctgccctgc ctttggggtc caccggcact   1320

ccagttggat ggcacaacat agtgtatccg tgcagaagcc gagctggcat tttcaccagt   1380

gtagccaagg gcctttgcca agggcagagc aggtggagcc ctctgcctgc cctatcacac   1440

atacgggtac ttgcttttca ctgtgatgtt taagagaatg tatgaacagt ttacattttc   1500

cttagaaata cattgatggg atcacagttg gctttaaaaa ccaacaacaa tcaaccacct   1560

gtaagtcttt gtcttcacct attatcatct ggaggtaaat ctctttatat gatgatgcca   1620

aagggcaaat tgcttttcaa attcagcaag ttctcagctt gtgtgacgga aggtccttca   1680

gaggacctga ggaatgcctg ggagaggcta agcctcaggc ttcaatgctt ctggggttgg   1740

gcatgaggat gtacacagac acccactacc ttactactca cacttcattt cactcctttt   1800

gtaaatttcc aatttaaaaa tcaagcacgt ctttttagtg agataaaatc tgagctcttc   1860

tgtagaaaaa tcaatctcta ccagtagaaa atgccagggc ttgatggaag agctgtgtag   1920

ccctttctat gccaaagcca ggaaatttgg ggggcaggag gaggttctca gaatccagtc   1980

tgtatctttg ctgtatgcca aactgaaacc actgggaata atttatgaaa cataaaaatc   2040

ttctgtactt cactccaagg tacatttgct tactgacagc atttttgtta aaactgttat   2100

tcttgacctg ttgtgtatgc gttagattct tcagttaaga gaaaagagat atttaagtga   2160

taaaatttat gcccttaagg gatcgtgcat catgtatttc aataaaatat gtgttgcatg   2220

aatccttagg ccaggcagaa agtcttga                                      2248


<210>  218
<211>  378
<212>  PRT
<213>  Homosapiens

<400>  218

Met Leu Pro Thr Arg Ile Leu Arg Leu Leu Glu Phe Val Gly Phe Ser 
1               5                   10                  15      


Gly Asn Lys Asp Tyr Gly Leu Leu Gln Leu Glu Glu Gly Ala Ser Gly 
            20                  25                  30          


His Ser Phe Arg Ser Val Leu Cys Val Met Leu Leu Leu Cys Tyr His 
        35                  40                  45              


Thr Phe Leu Thr Phe Val Leu Gly Thr Gly Asn Val Asn Ile Glu Glu 
    50                  55                  60                  


Ala Glu Lys Leu Leu Lys Pro Tyr Leu Asn Arg Tyr Pro Lys Gly Ala 
65                  70                  75                  80  


Ile Phe Leu Phe Phe Ala Gly Arg Ile Glu Val Ile Lys Gly Asn Ile 
                85                  90                  95      


Asp Ala Ala Ile Arg Arg Phe Glu Glu Cys Cys Glu Ala Gln Gln His 
            100                 105                 110         


Trp Lys Gln Phe His His Met Cys Tyr Trp Glu Leu Met Trp Cys Phe 
        115                 120                 125             


Thr Tyr Lys Gly Gln Trp Lys Met Ser Tyr Phe Tyr Ala Asp Leu Leu 
    130                 135                 140                 


Ser Lys Glu Asn Cys Trp Ser Lys Ala Thr Tyr Ile Tyr Met Lys Ala 
145                 150                 155                 160 


Ala Tyr Leu Ser Met Phe Gly Lys Glu Asp His Lys Pro Phe Gly Asp 
                165                 170                 175     


Asp Glu Val Glu Leu Phe Arg Ala Val Pro Gly Leu Lys Leu Lys Ile 
            180                 185                 190         


Ala Gly Lys Ser Leu Pro Thr Glu Lys Phe Ala Ile Arg Lys Ser Arg 
        195                 200                 205             


Arg Tyr Phe Ser Ser Asn Pro Ile Ser Leu Pro Val Pro Ala Leu Glu 
    210                 215                 220                 


Met Met Tyr Ile Trp Asn Gly Tyr Ala Val Ile Gly Lys Gln Pro Lys 
225                 230                 235                 240 


Leu Thr Asp Gly Ile Leu Glu Ile Ile Thr Lys Ala Glu Glu Met Leu 
                245                 250                 255     


Glu Lys Gly Pro Glu Asn Glu Tyr Ser Val Asp Asp Glu Cys Leu Val 
            260                 265                 270         


Lys Leu Leu Lys Gly Leu Cys Leu Lys Tyr Leu Gly Arg Val Gln Glu 
        275                 280                 285             


Ala Glu Glu Asn Phe Arg Ser Ile Ser Ala Asn Glu Lys Lys Ile Lys 
    290                 295                 300                 


Tyr Asp His Tyr Leu Ile Pro Asn Ala Leu Leu Glu Leu Ala Leu Leu 
305                 310                 315                 320 


Leu Met Glu Gln Asp Arg Asn Glu Glu Ala Ile Lys Leu Leu Glu Ser 
                325                 330                 335     


Ala Lys Gln Asn Tyr Lys Asn Tyr Ser Met Glu Ser Arg Thr His Phe 
            340                 345                 350         


Arg Ile Gln Ala Ala Thr Leu Gln Ala Lys Ser Ser Leu Glu Asn Ser 
        355                 360                 365             


Ser Arg Ser Met Val Ser Ser Val Ser Leu 
    370                 375             


<210>  219
<211>  2856
<212>  DNA
<213>  Homosapiens

<400>  219
cgcccggctc ggggttgcgg cggcagcacc tgggccgcga ttggcgtccg gctggggcag     60

cgccgcccgc gcccctcggc gatgacctcg gctggcggcg ccccaggagc cctgcccgcg    120

gggactcctg agagcagcct ccatgaggcc ctggaccagt gcatgaccgc cctggacctc    180

ttcctcacca accagttctc agaagcactc agctacctca agcccagaac caaggaaagc    240

atgtaccact cactgacata tgccaccatc ctggagatgc aggccatgat gacctttgac    300

cctcaggaca tcctgcttgc cggcaacatg atgaaggagg cacagatgct gtgtcagagg    360

caccggagga agtcttctgt aacagattcc ttcagcagcc tggtgaaccg ccccacgctg    420

ggccaattca ctgaagagga aatccacgct gaggtctgct atgcagagtg cctgctgcag    480

cgagcagccc tgaccttcct gcaggacgag aacatggtga gcttcatcaa aggcggcatc    540

aaagttcgaa acagctacca gacctacaag gagctggaca gccttgttca gtcctcacaa    600

tactgcaagg gtgagaacca cccgcacttt gaaggaggag tgaagcttgg tgtaggggcc    660

ttcaacctga cactgtccat gcttcctact aggatcctga ggctgttgga gtttgtgggg    720

ttttcaggaa acaaggacta tgggctgctg cagctggagg agggagcgtc agggcacagc    780

ttccgctctg tgctctgtgt catgctcctg ctgtgctacc acaccttcct caccttcgtg    840

ctcggtactg ggaacgtcaa catcgaggag gccgagaagc tcttgaagcc ctacctgaac    900

cggtacccta agggtgccat cttcctgttc tttgcaggga ggattgaagt cattaaaggc    960

aacattgatg cagccatccg gcgtttcgag gagtgctgtg aggcccagca gcactggaag   1020

cagttccacc acatgtgcta ctgggagctg atgtggtgct tcacctacaa gggccagtgg   1080

aagatgtcct acttctacgc cgacctgctc agcaaggaga actgctggtc caaggccacc   1140

tacatttaca tgaaggccgc ctacctcagc atgtttggga aggaggacca caagccgttc   1200

ggggacgacg aagtggaatt atttcgagct gtgccaggcc tgaagctcaa gattgctggg   1260

aaatctctac ccacagagaa gtttgccatc cggaagtccc ggcgctactt ctcctccaac   1320

cctatctcgc tgccagtgcc tgctctggaa atgatgtaca tctggaacgg ctacgccgtg   1380

attgggaagc agccgaaact cacggatggg atacttgaga ttatcactaa ggctgaagag   1440

atgctggaga aaggcccaga gaacgagtac tcagtggatg acgagtgctt ggtgaaattg   1500

ttgaaaggcc tgtgtctgaa atacctgggc cgtgtccagg aggccgagga gaattttagg   1560

agcatctctg ccaatgaaaa gaagattaaa tatgaccact acttgatccc aaacgccctg   1620

ctggagctgg ccctgctgct tatggagcaa gacagaaacg aagaggccat caaacttttg   1680

gaatctgcca agcaaaacta caagaattac tccatggagt caaggacaca ctttcgaatc   1740

caggcagcca cactccaagc caagtcttcc ctagagaaca gcagcagatc catggtctca   1800

tcagtgtcct tgtagctttg tgcagcagtt ccgggctgga agacagagac agctggacag   1860

agctcctgaa aacatttcaa aataccccct ccccctgccc tgccctgcct ttggggtcca   1920

ccggcactcc agttggatgg cacaacatag tgtatccgtg cagaagccga gctggcattt   1980

tcaccagtgt agccaagggc ctttgccaag ggcagagcag gtggagccct ctgcctgccc   2040

tatcacacat acgggtactt gcttttcact gtgatgttta agagaatgta tgaacagttt   2100

acattttcct tagaaataca ttgatgggat cacagttggc tttaaaaacc aacaacaatc   2160

aaccacctgt aagtctttgt cttcacctat tatcatctgg aggtaaatct ctttatatga   2220

tgatgccaaa gggcaaattg cttttcaaat tcagcaagtt ctcagcttgt gtgacggaag   2280

gtccttcaga ggacctgagg aatgcctggg agaggctaag cctcaggctt caatgcttct   2340

ggggttgggc atgaggatgt acacagacac ccactacctt actactcaca cttcatttca   2400

ctccttttgt aaatttccaa tttaaaaatc aagcacgtct ttttagtgag ataaaatctg   2460

agctcttctg tagaaaaatc aatctctacc agtagaaaat gccagggctt gatggaagag   2520

ctgtgtagcc ctttctatgc caaagccagg aaatttgggg ggcaggagga ggttctcaga   2580

atccagtctg tatctttgct gtatgccaaa ctgaaaccac tgggaataat ttatgaaaca   2640

taaaaatctt ctgtacttca ctccaaggta catttgctta ctgacagcat ttttgttaaa   2700

actgttattc ttgacctgtt gtgtatgcgt tagattcttc agttaagaga aaagagatat   2760

ttaagtgata aaatttatgc ccttaaggga tcgtgcatca tgtatttcaa taaaatatgt   2820

gttgcatgaa tccttaggcc aggcagaaag tcttga                             2856


<210>  220
<211>  577
<212>  PRT
<213>  Homosapiens

<400>  220

Met Thr Ser Ala Gly Gly Ala Pro Gly Ala Leu Pro Ala Gly Thr Pro 
1               5                   10                  15      


Glu Ser Ser Leu His Glu Ala Leu Asp Gln Cys Met Thr Ala Leu Asp 
            20                  25                  30          


Leu Phe Leu Thr Asn Gln Phe Ser Glu Ala Leu Ser Tyr Leu Lys Pro 
        35                  40                  45              


Arg Thr Lys Glu Ser Met Tyr His Ser Leu Thr Tyr Ala Thr Ile Leu 
    50                  55                  60                  


Glu Met Gln Ala Met Met Thr Phe Asp Pro Gln Asp Ile Leu Leu Ala 
65                  70                  75                  80  


Gly Asn Met Met Lys Glu Ala Gln Met Leu Cys Gln Arg His Arg Arg 
                85                  90                  95      


Lys Ser Ser Val Thr Asp Ser Phe Ser Ser Leu Val Asn Arg Pro Thr 
            100                 105                 110         


Leu Gly Gln Phe Thr Glu Glu Glu Ile His Ala Glu Val Cys Tyr Ala 
        115                 120                 125             


Glu Cys Leu Leu Gln Arg Ala Ala Leu Thr Phe Leu Gln Asp Glu Asn 
    130                 135                 140                 


Met Val Ser Phe Ile Lys Gly Gly Ile Lys Val Arg Asn Ser Tyr Gln 
145                 150                 155                 160 


Thr Tyr Lys Glu Leu Asp Ser Leu Val Gln Ser Ser Gln Tyr Cys Lys 
                165                 170                 175     


Gly Glu Asn His Pro His Phe Glu Gly Gly Val Lys Leu Gly Val Gly 
            180                 185                 190         


Ala Phe Asn Leu Thr Leu Ser Met Leu Pro Thr Arg Ile Leu Arg Leu 
        195                 200                 205             


Leu Glu Phe Val Gly Phe Ser Gly Asn Lys Asp Tyr Gly Leu Leu Gln 
    210                 215                 220                 


Leu Glu Glu Gly Ala Ser Gly His Ser Phe Arg Ser Val Leu Cys Val 
225                 230                 235                 240 


Met Leu Leu Leu Cys Tyr His Thr Phe Leu Thr Phe Val Leu Gly Thr 
                245                 250                 255     


Gly Asn Val Asn Ile Glu Glu Ala Glu Lys Leu Leu Lys Pro Tyr Leu 
            260                 265                 270         


Asn Arg Tyr Pro Lys Gly Ala Ile Phe Leu Phe Phe Ala Gly Arg Ile 
        275                 280                 285             


Glu Val Ile Lys Gly Asn Ile Asp Ala Ala Ile Arg Arg Phe Glu Glu 
    290                 295                 300                 


Cys Cys Glu Ala Gln Gln His Trp Lys Gln Phe His His Met Cys Tyr 
305                 310                 315                 320 


Trp Glu Leu Met Trp Cys Phe Thr Tyr Lys Gly Gln Trp Lys Met Ser 
                325                 330                 335     


Tyr Phe Tyr Ala Asp Leu Leu Ser Lys Glu Asn Cys Trp Ser Lys Ala 
            340                 345                 350         


Thr Tyr Ile Tyr Met Lys Ala Ala Tyr Leu Ser Met Phe Gly Lys Glu 
        355                 360                 365             


Asp His Lys Pro Phe Gly Asp Asp Glu Val Glu Leu Phe Arg Ala Val 
    370                 375                 380                 


Pro Gly Leu Lys Leu Lys Ile Ala Gly Lys Ser Leu Pro Thr Glu Lys 
385                 390                 395                 400 


Phe Ala Ile Arg Lys Ser Arg Arg Tyr Phe Ser Ser Asn Pro Ile Ser 
                405                 410                 415     


Leu Pro Val Pro Ala Leu Glu Met Met Tyr Ile Trp Asn Gly Tyr Ala 
            420                 425                 430         


Val Ile Gly Lys Gln Pro Lys Leu Thr Asp Gly Ile Leu Glu Ile Ile 
        435                 440                 445             


Thr Lys Ala Glu Glu Met Leu Glu Lys Gly Pro Glu Asn Glu Tyr Ser 
    450                 455                 460                 


Val Asp Asp Glu Cys Leu Val Lys Leu Leu Lys Gly Leu Cys Leu Lys 
465                 470                 475                 480 


Tyr Leu Gly Arg Val Gln Glu Ala Glu Glu Asn Phe Arg Ser Ile Ser 
                485                 490                 495     


Ala Asn Glu Lys Lys Ile Lys Tyr Asp His Tyr Leu Ile Pro Asn Ala 
            500                 505                 510         


Leu Leu Glu Leu Ala Leu Leu Leu Met Glu Gln Asp Arg Asn Glu Glu 
        515                 520                 525             


Ala Ile Lys Leu Leu Glu Ser Ala Lys Gln Asn Tyr Lys Asn Tyr Ser 
    530                 535                 540                 


Met Glu Ser Arg Thr His Phe Arg Ile Gln Ala Ala Thr Leu Gln Ala 
545                 550                 555                 560 


Lys Ser Ser Leu Glu Asn Ser Ser Arg Ser Met Val Ser Ser Val Ser 
                565                 570                 575     


Leu 
    


<210>  221
<211>  5220
<212>  DNA
<213>  Homosapiens

<400>  221
ggcctcgcct gcggccgctc cctccgcctc ctccccgccc cgagccccag tcagcccgtc     60

ttccttcccc tcccttgcat gatggaaaca ccatggctgc ggcggcccag ctctctctga    120

cacagttatc aagtgggaat cctgtatatg aaaaatacta tagacaggtt gatacaggca    180

atactggaag ggtgttggct tctgatgctg ctgctttcct gaaaaaatca gggcttccag    240

acttgatact tggaaagatt tgggatttag ccgacacaga tggcaaaggt atcctgaaca    300

aacaagaatt ctttgttgct ttgcgtcttg tggcatgtgc ccagaatgga ttggaagttt    360

cactaagtag tttgaacctg gctgttcctc caccaagatt tcatgatacc agtagtcctt    420

tgctaatcag tggaacctct gcagctgagc tcccatgggc tgtaaaacct gaagataagg    480

ccaaatatga tgcaatattt gatagtttaa gcccagtgaa tggatttctg tctggtgata    540

aagtgaaacc agtgttgctc aactctaagt tacctgtgga tatccttgga agagtttggg    600

agttgagtga tattgaccat gatggaatgc ttgacagaga tgagtttgca gttgccatgt    660

ttttggtata ctgtgcactg gagaaagaac ctgtgccaat gtccttgcct ccagccttgg    720

tgccaccatc taagagaaaa acgtgggttg tatcccctgc agaaaaagct aaatatgatg    780

aaatcttcct gaaaactgat aaagatatgg acggatttgt gtctggattg gaggtccgtg    840

aaatattctt gaaaacaggt ttaccttcta ccttactagc ccatatatgg tcattatgcg    900

acacaaagga ctgtgggaag ctttcaaagg atcagtttgc cttggctttt cacttaatca    960

gtcagaagtt aatcaagggc attgatcctc ctcacgttct tactcctgaa atgattccac   1020

catcagacag ggccagttta caaaagaaca tcataggatc aagtcctgtt gcagatttct   1080

ctgctattaa ggaactagat actcttaaca atgaaatagt tgacctacag agggaaaaga   1140

ataatgtgga acaggacctt aaggagaagg aagatactat taaacagagg acaagtgagg   1200

ttcaggatct tcaagatgaa gttcaaaggg agaatactaa tctgcaaaaa ctacaggccc   1260

agaaacagca ggtacaggaa ctccttgatg aactggatga gcagaaagcc cagctggagg   1320

agcaactcaa ggaagtcaga aagaaatgtg ctgaggaggc ccaactgatc tcttctctga   1380

aagctgaatt aactagtcag gaatcgcaga tctccactta cgaagaagaa ttggcaaaag   1440

ctagagaaga gctgagccgt ctacagcaag aaacagcaga attggaggag agtgtagagt   1500

cagggaaggc tcagttggaa cctcttcagc agcacctaca agattcacaa caggaaatta   1560

gttcaatgca aatgaaactg atggaaatga aagatttgga aaatcataat agtcagttaa   1620

attggtgcag tagcccacac agcattcttg taaacggagc tacagattat tgcagcctca   1680

gcaccagcag cagtgaaaca gccaacctta atgaacatgt tgaaggccag agcaacctag   1740

agtctgagcc catacaccag gaatctccag caagaagtag tcctgaacta ctgccttctg   1800

gtgtgactga tgaaaatgag gtgactacag ctgttactga aaaagtttgt tctgaactcg   1860

acaataatag acattcaaaa gaggaagatc catttaatgt agactcaagt tcgctgacag   1920

gtccagttgc agatacaaac ttggattttt tccagtctga tccttttgtt ggcagtgatc   1980

ctttcaagga tgatcctttt ggaaaaatcg atccatttgg tggtgatcct ttcaaaggtt   2040

cagatccatt tgcatcagac tgtttcttca ggcaatctac tgatcctttt gccacttcaa   2100

gcactgaccc tttcagtgca gccaacaata gcagtattac atcggtagaa acgttgaagc   2160

acaatgatcc ttttgctcct ggtggaacag ttgttgcagc aagcgattca gccacagacc   2220

cctttgcttc tgtttttggg aatgaatcat ttggaggtgg atttgctgac ttcagcacat   2280

tgtcaaaggt caacaatgaa gatccttttc gttcagccac atcgagctct gtcagcaacg   2340

tagtgattac aaaaaatgta tttgaggaaa catcggtcaa aagtgaagat gaacccccag   2400

cactgccacc aaagatcgga actccaacaa gaccctgccc tctaccacct gggaaaagat   2460

ccatcaacaa attggattct cctgatccct ttaaactgaa tgatccattt cagcctttcc   2520

caggcaacga tagccccaaa gaaaaagatc ctgaaatatt ttgtgatcca ttcacttctg   2580

ctactaccac taccaataaa gaggctgatc caagcaattt tgccaacttc agtgcttatc   2640

cctctgaaga agatatgatc gaatgggcca agagggaaag tgagagagag gaagagcaga   2700

ggcttgcccg actaaatcag caggaacaag aagacttaga actggctatt gcactcagca   2760

aatctgagat atcagaagca tgaagaattc tcttgttctt tggcaacaat atagtattct   2820

tcttcctgaa tactgaaact atttacaatg tgtatcaaaa ctacctgtga gcatgggaat   2880

acaaaaggtt tgagattcct gtaaatgtga caaaatttta ggattttttt tttttcttca   2940

ttacagattc gtcttttttt ttttttctta taaaagccgt aacccagtca gacaaattca   3000

ccttcactta ggcccctgtt ctggtataca tttactgtga gcttttgcct gcctgtgcta   3060

ttttacttgt aaagctagag cacccaagct tctgccttct ggaatataga gaaatagttt   3120

caccctgcac taccctgttc tgtagttatt ctgatgatag ccagtgaggt tcttaaagtt   3180

tgcagtattc tcccctgatt ggaatggttg agtgagggta agggaaagaa tatcttattt   3240

cttttatgat tggtgcaaat tggctaaagt gcatttttaa atttcctcta cttaatttgt   3300

ttttcagaga taaggaaaaa tattttgcac agatttactc cactatggaa aagggatgct   3360

gtaggttgaa ccattatagc ctcagattcg atcttttcct aactaaaaat attaaagcct   3420

catgtgtgaa ataaattttt aaaaagattt atctggattt agagaatttt agatcaacag   3480

atacctctca gtgtgtttgc taattaataa aaatcagttt cttacaaata aagtttgtaa   3540

gaaaatgttc attttaagtg atagatagtg gagaaaattt atcacctaaa atatacccat   3600

cagtataagg caagcaaaag tcttaacatg gcagccattc tgcctttgcc gtggccctgt   3660

cctgtttagt tcttagtggg ttaatttttg tacttttgca gaagaaactt cagcaagcta   3720

gaactggaag gtactttaat ttttcatata tatttgtttt ttttttttta atgaaggctc   3780

atttacttga aatgtaaaaa ctttcactga atacaaatag aaaaagtgat gtgttttata   3840

tcatattgct ttttgtccat ctttgtggtt tagtttattt actcacttca tgtttttcac   3900

ctataaaatt gtcaagctag caaaaaaact cttgtttttt taattgggag agaagagacc   3960

tgccagatta tcagacctct tcatgttaaa agaccatctc ctgtaaaact gacctagtgg   4020

acaagctgaa tttgaaatag actgtgaagt aagctgtaac ttgtcatttt aattttgttt   4080

aacacggtta ctgacttaga tgatgtatta aataccaaga taaagaaaaa tgcacctaaa   4140

atctaattag aattctctgg gtcaacaagt caaggtggta ttgatctgtg ttaatctgag   4200

taacttattg cctagcctat aaataaattc caaaatatcc aattcatttc ttcttgaaat   4260

ggtgcttgtt ttgttttctt tccattacac aattagactc ctacagttta aaacaaactt   4320

taaaccacta tcttgcactg ctaacttttt tctacctttg taaatagaaa catttctgca   4380

taaaagtcat acatatgaag caagggctga atcataatca caaggcttaa ttttgataaa   4440

cgaatccagt gacctaagga ttttctgcaa aatttgactg ggagttgtga taggtggtat   4500

ttttgtttat tttcttcctc ttactcctta ggataaaggt aagttgactt gaacaacttt   4560

cttttgcact gggaaaataa gcaaatgttt aaatgcttca aaaaaatttt caattaaact   4620

caaatattaa atatctataa cttataaaca ccaactttca atgtaataaa tgtatcctaa   4680

tcttatgtat gtttaactgg attacataga tttttatctt ttgttaaaat gtgtataccc   4740

cgtggaccaa cataatatta aagtatgtat atattatata aatatatatg tatatgtgct   4800

cgcttgtgta ggatgaatgt cttagagtcg tttgtggtat tttatgttgt tgactctggc   4860

tccagggcct gtgcttgaaa aggacagata agtattgccc agagctaagt ggcactactt   4920

acaaagtttt aaatgtcttc tacatactga ttcatgttta tttgagctct ctttatagaa   4980

ttttctctta aagtttcaaa cctctaagtt gtagcctgta attatgagaa cagtaaactt   5040

taagtaataa taaagaatcc catccatata tccaatttgc aattgagttt tgcatggttc   5100

tctgattatg tccatgctgt gtccaaggag gagtaggtac atacaatcag cacagattaa   5160

tatatgtaaa gggtttggga cagcacctgg tatagaataa ataataaatg taaactatta   5220


<210>  222
<211>  896
<212>  PRT
<213>  Homosapiens

<400>  222

Met Ala Ala Ala Ala Gln Leu Ser Leu Thr Gln Leu Ser Ser Gly Asn 
1               5                   10                  15      


Pro Val Tyr Glu Lys Tyr Tyr Arg Gln Val Asp Thr Gly Asn Thr Gly 
            20                  25                  30          


Arg Val Leu Ala Ser Asp Ala Ala Ala Phe Leu Lys Lys Ser Gly Leu 
        35                  40                  45              


Pro Asp Leu Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Thr Asp Gly 
    50                  55                  60                  


Lys Gly Ile Leu Asn Lys Gln Glu Phe Phe Val Ala Leu Arg Leu Val 
65                  70                  75                  80  


Ala Cys Ala Gln Asn Gly Leu Glu Val Ser Leu Ser Ser Leu Asn Leu 
                85                  90                  95      


Ala Val Pro Pro Pro Arg Phe His Asp Thr Ser Ser Pro Leu Leu Ile 
            100                 105                 110         


Ser Gly Thr Ser Ala Ala Glu Leu Pro Trp Ala Val Lys Pro Glu Asp 
        115                 120                 125             


Lys Ala Lys Tyr Asp Ala Ile Phe Asp Ser Leu Ser Pro Val Asn Gly 
    130                 135                 140                 


Phe Leu Ser Gly Asp Lys Val Lys Pro Val Leu Leu Asn Ser Lys Leu 
145                 150                 155                 160 


Pro Val Asp Ile Leu Gly Arg Val Trp Glu Leu Ser Asp Ile Asp His 
                165                 170                 175     


Asp Gly Met Leu Asp Arg Asp Glu Phe Ala Val Ala Met Phe Leu Val 
            180                 185                 190         


Tyr Cys Ala Leu Glu Lys Glu Pro Val Pro Met Ser Leu Pro Pro Ala 
        195                 200                 205             


Leu Val Pro Pro Ser Lys Arg Lys Thr Trp Val Val Ser Pro Ala Glu 
    210                 215                 220                 


Lys Ala Lys Tyr Asp Glu Ile Phe Leu Lys Thr Asp Lys Asp Met Asp 
225                 230                 235                 240 


Gly Phe Val Ser Gly Leu Glu Val Arg Glu Ile Phe Leu Lys Thr Gly 
                245                 250                 255     


Leu Pro Ser Thr Leu Leu Ala His Ile Trp Ser Leu Cys Asp Thr Lys 
            260                 265                 270         


Asp Cys Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala Phe His Leu 
        275                 280                 285             


Ile Ser Gln Lys Leu Ile Lys Gly Ile Asp Pro Pro His Val Leu Thr 
    290                 295                 300                 


Pro Glu Met Ile Pro Pro Ser Asp Arg Ala Ser Leu Gln Lys Asn Ile 
305                 310                 315                 320 


Ile Gly Ser Ser Pro Val Ala Asp Phe Ser Ala Ile Lys Glu Leu Asp 
                325                 330                 335     


Thr Leu Asn Asn Glu Ile Val Asp Leu Gln Arg Glu Lys Asn Asn Val 
            340                 345                 350         


Glu Gln Asp Leu Lys Glu Lys Glu Asp Thr Ile Lys Gln Arg Thr Ser 
        355                 360                 365             


Glu Val Gln Asp Leu Gln Asp Glu Val Gln Arg Glu Asn Thr Asn Leu 
    370                 375                 380                 


Gln Lys Leu Gln Ala Gln Lys Gln Gln Val Gln Glu Leu Leu Asp Glu 
385                 390                 395                 400 


Leu Asp Glu Gln Lys Ala Gln Leu Glu Glu Gln Leu Lys Glu Val Arg 
                405                 410                 415     


Lys Lys Cys Ala Glu Glu Ala Gln Leu Ile Ser Ser Leu Lys Ala Glu 
            420                 425                 430         


Leu Thr Ser Gln Glu Ser Gln Ile Ser Thr Tyr Glu Glu Glu Leu Ala 
        435                 440                 445             


Lys Ala Arg Glu Glu Leu Ser Arg Leu Gln Gln Glu Thr Ala Glu Leu 
    450                 455                 460                 


Glu Glu Ser Val Glu Ser Gly Lys Ala Gln Leu Glu Pro Leu Gln Gln 
465                 470                 475                 480 


His Leu Gln Asp Ser Gln Gln Glu Ile Ser Ser Met Gln Met Lys Leu 
                485                 490                 495     


Met Glu Met Lys Asp Leu Glu Asn His Asn Ser Gln Leu Asn Trp Cys 
            500                 505                 510         


Ser Ser Pro His Ser Ile Leu Val Asn Gly Ala Thr Asp Tyr Cys Ser 
        515                 520                 525             


Leu Ser Thr Ser Ser Ser Glu Thr Ala Asn Leu Asn Glu His Val Glu 
    530                 535                 540                 


Gly Gln Ser Asn Leu Glu Ser Glu Pro Ile His Gln Glu Ser Pro Ala 
545                 550                 555                 560 


Arg Ser Ser Pro Glu Leu Leu Pro Ser Gly Val Thr Asp Glu Asn Glu 
                565                 570                 575     


Val Thr Thr Ala Val Thr Glu Lys Val Cys Ser Glu Leu Asp Asn Asn 
            580                 585                 590         


Arg His Ser Lys Glu Glu Asp Pro Phe Asn Val Asp Ser Ser Ser Leu 
        595                 600                 605             


Thr Gly Pro Val Ala Asp Thr Asn Leu Asp Phe Phe Gln Ser Asp Pro 
    610                 615                 620                 


Phe Val Gly Ser Asp Pro Phe Lys Asp Asp Pro Phe Gly Lys Ile Asp 
625                 630                 635                 640 


Pro Phe Gly Gly Asp Pro Phe Lys Gly Ser Asp Pro Phe Ala Ser Asp 
                645                 650                 655     


Cys Phe Phe Arg Gln Ser Thr Asp Pro Phe Ala Thr Ser Ser Thr Asp 
            660                 665                 670         


Pro Phe Ser Ala Ala Asn Asn Ser Ser Ile Thr Ser Val Glu Thr Leu 
        675                 680                 685             


Lys His Asn Asp Pro Phe Ala Pro Gly Gly Thr Val Val Ala Ala Ser 
    690                 695                 700                 


Asp Ser Ala Thr Asp Pro Phe Ala Ser Val Phe Gly Asn Glu Ser Phe 
705                 710                 715                 720 


Gly Gly Gly Phe Ala Asp Phe Ser Thr Leu Ser Lys Val Asn Asn Glu 
                725                 730                 735     


Asp Pro Phe Arg Ser Ala Thr Ser Ser Ser Val Ser Asn Val Val Ile 
            740                 745                 750         


Thr Lys Asn Val Phe Glu Glu Thr Ser Val Lys Ser Glu Asp Glu Pro 
        755                 760                 765             


Pro Ala Leu Pro Pro Lys Ile Gly Thr Pro Thr Arg Pro Cys Pro Leu 
    770                 775                 780                 


Pro Pro Gly Lys Arg Ser Ile Asn Lys Leu Asp Ser Pro Asp Pro Phe 
785                 790                 795                 800 


Lys Leu Asn Asp Pro Phe Gln Pro Phe Pro Gly Asn Asp Ser Pro Lys 
                805                 810                 815     


Glu Lys Asp Pro Glu Ile Phe Cys Asp Pro Phe Thr Ser Ala Thr Thr 
            820                 825                 830         


Thr Thr Asn Lys Glu Ala Asp Pro Ser Asn Phe Ala Asn Phe Ser Ala 
        835                 840                 845             


Tyr Pro Ser Glu Glu Asp Met Ile Glu Trp Ala Lys Arg Glu Ser Glu 
    850                 855                 860                 


Arg Glu Glu Glu Gln Arg Leu Ala Arg Leu Asn Gln Gln Glu Gln Glu 
865                 870                 875                 880 


Asp Leu Glu Leu Ala Ile Ala Leu Ser Lys Ser Glu Ile Ser Glu Ala 
                885                 890                 895     


<210>  223
<211>  2919
<212>  DNA
<213>  Homosapiens

<400>  223
gtcattggcg gctcccaaga tggcgtccat catggaaggg ccgctgagca aatggactaa     60

cgtgatgaag ggctggcagt accgttggtt cgtgctggac tacaatgcag gactgctctc    120

ctactacacg tccaaggaca aaatgatgag aggctctcgc agaggatgtg ttagactcag    180

aggagctgtg attggtatag acgatgagga cgacagcacc ttcacaataa ctgttgatca    240

gaaaaccttc catttccagg cccgtgatgc tgatgagcga gagaagtgga tccatgcctt    300

agaagaaaca attcttcgac atactctcca gcttcaaggt ttggattcag gatttgttcc    360

tagtgtccaa gattttgata agaaacttac agaagctgat gcttacctac aaatcttgat    420

tgaacaatta aagctttttg atgacaagct tcaaaactgc aaagaagatg aacagagaaa    480

gaaaattgaa actctcaaag agacaacaaa tagcatggta gaatcaatta aacactgcat    540

tgtgttgctg cagattgcca aagaccagag taatgcggag aagcacgcag atggaatgat    600

aagtactatt aatcccgtag atgcaatata tcaacctagt cctttggaac ctgtgatcag    660

cacaatgcct tcccagactg tgttacctcc agaacctgtt cagttgtgta agtcagagca    720

gcgtccatct tccctaccag ttggacctgt gttggctacc ttgggacatc atcagactcc    780

tacaccaaat agtacaggca gtggccattc accaccgagt agcagtctca cttctccaag    840

ccacgtgaac ttgtctccaa atacagtccc agagttctct tactccagca gtgaagatga    900

attttatgat gctgatgaat tccatcaaag tggctcatcc ccaaagcgct taatagattc    960

ttctggatct gcctcagtcc tgacacacag cagctcggga aatagtctaa aacgcccaga   1020

taccacagaa tcacttaatt cttccttgtc caatggaaca agtgatgctg acctgtttga   1080

ttcacatgat gacagagatg atgatgcgga ggcagggtct gtggaggagc acaagagcgt   1140

tatcatgcat ctcttgtcgc aggttagact tggaatggat cttactaagg tagttcttcc   1200

aacgtttatt cttgaaagaa gatctctttt agaaatgtat gcagactttt ttgcacatcc   1260

ggacctgttt gtgagcatta gtgaccagaa ggatcccaag gatcgaatgg ttcaggttgt   1320

gaaatggtac ctctcagcct ttcatgcggg aaggaaagga tcagttgcca aaaagccata   1380

caatcccatt ttgggcgaga tttttcagtg tcattggaca ttaccaaatg atactgaaga   1440

gaacacagaa ctagtttcag aaggaccagt tccctgggtt tccaaaaaca gtgtaacatt   1500

tgtggctgag caggtttccc atcatccacc catttcagcc ttttatgctg agtgttttaa   1560

caagaagata caattcaatg ctcatatctg gaccaaatca aaattccttg ggatgtcaat   1620

tggggtgcac aacatagggc agggctgtgt ctcatgtcta gactatgatg aacattacat   1680

tctcacattc cccaatggct atggaaggtc tatcctcaca gtgccctggg tggaattagg   1740

aggagaatgc aatattaatt gttccaaaac aggctatagt gcaaatatca tcttccacac   1800

taaacccttc tatgggggca agaagcacag aattactgcc gagatttttt ctccaaatga   1860

caagaagtct ttttgctcaa ttgaagggga atggaatggt gtgatgtatg caaaatatgc   1920

aacaggggaa aatacagtct ttgtagatac caagaagttg cctataatca agaagaaagt   1980

gaggaagttg gaagatcaga acgagtatga atcccgcagc ctttggaagg atgtcacttt   2040

caacttaaaa atcagagaca ttgatgcagc aactgaagca aagcacaggc ttgaagaaag   2100

acaaagagca gaagcccgag aaaggaagga gaaggaaatt cagtgggaga caaggttatt   2160

tcatgaagat ggagaatgct gggtttatga tgaaccatta ctgaaacgtc ttggtgctgc   2220

caagcattag gttggaagat gcaaagttta tacctgatga tcagggcagt aggcataatt   2280

cagcaacaaa caatcttcct ttgggagaaa cctgttcatt ccaatcttct aattacagtg   2340

gttcctatct cagggatact ggactttctg acgcagatga acaattaagg ggaaaagctt   2400

cccttttccc tctgtggcag ttacgatttt gacttcagtc ctgagaaaaa cttcaggttt   2460

tgaaaatcag atgatgtctt ctccttttcc aaacaccaca cgttgaaagc atttataaat   2520

ccaagtctga aactctgcgc tctagtactg ctgttaagat acacaacttg tttcttagtt   2580

catataatct cgggatacac acacacacac acatatatat acacacacat acgtatacac   2640

acacatacat atatataaat atacctgatg ccagattttt ttcataaata ttctgcctac   2700

tgtaaatatg ggttcctctg agttgtttta gaaaattagc gcaatgtatt aaaatcaagt   2760

gttaggaaat ttcatggtct tacctacaat aacttttatt ttggaattga actattatta   2820

aattgtatct aatcctggat tacagtttaa ttaattattc ttagtgctta aggcttcata   2880

aagtaatttt tccaaccttt tttttaaaaa aaaaaaaaa                          2919


<210>  224
<211>  736
<212>  PRT
<213>  Homosapiens

<400>  224

Met Ala Ser Ile Met Glu Gly Pro Leu Ser Lys Trp Thr Asn Val Met 
1               5                   10                  15      


Lys Gly Trp Gln Tyr Arg Trp Phe Val Leu Asp Tyr Asn Ala Gly Leu 
            20                  25                  30          


Leu Ser Tyr Tyr Thr Ser Lys Asp Lys Met Met Arg Gly Ser Arg Arg 
        35                  40                  45              


Gly Cys Val Arg Leu Arg Gly Ala Val Ile Gly Ile Asp Asp Glu Asp 
    50                  55                  60                  


Asp Ser Thr Phe Thr Ile Thr Val Asp Gln Lys Thr Phe His Phe Gln 
65                  70                  75                  80  


Ala Arg Asp Ala Asp Glu Arg Glu Lys Trp Ile His Ala Leu Glu Glu 
                85                  90                  95      


Thr Ile Leu Arg His Thr Leu Gln Leu Gln Gly Leu Asp Ser Gly Phe 
            100                 105                 110         


Val Pro Ser Val Gln Asp Phe Asp Lys Lys Leu Thr Glu Ala Asp Ala 
        115                 120                 125             


Tyr Leu Gln Ile Leu Ile Glu Gln Leu Lys Leu Phe Asp Asp Lys Leu 
    130                 135                 140                 


Gln Asn Cys Lys Glu Asp Glu Gln Arg Lys Lys Ile Glu Thr Leu Lys 
145                 150                 155                 160 


Glu Thr Thr Asn Ser Met Val Glu Ser Ile Lys His Cys Ile Val Leu 
                165                 170                 175     


Leu Gln Ile Ala Lys Asp Gln Ser Asn Ala Glu Lys His Ala Asp Gly 
            180                 185                 190         


Met Ile Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro 
        195                 200                 205             


Leu Glu Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val Leu Pro Pro 
    210                 215                 220                 


Glu Pro Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro 
225                 230                 235                 240 


Val Gly Pro Val Leu Ala Thr Leu Gly His His Gln Thr Pro Thr Pro 
                245                 250                 255     


Asn Ser Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser 
            260                 265                 270         


Pro Ser His Val Asn Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr 
        275                 280                 285             


Ser Ser Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe His Gln Ser 
    290                 295                 300                 


Gly Ser Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser Ala Ser Val 
305                 310                 315                 320 


Leu Thr His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr 
                325                 330                 335     


Glu Ser Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu 
            340                 345                 350         


Phe Asp Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val 
        355                 360                 365             


Glu Glu His Lys Ser Val Ile Met His Leu Leu Ser Gln Val Arg Leu 
    370                 375                 380                 


Gly Met Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile Leu Glu Arg 
385                 390                 395                 400 


Arg Ser Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu 
                405                 410                 415     


Phe Val Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg Met Val Gln 
            420                 425                 430         


Val Val Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser 
        435                 440                 445             


Val Ala Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys 
    450                 455                 460                 


His Trp Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser 
465                 470                 475                 480 


Glu Gly Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala 
                485                 490                 495     


Glu Gln Val Ser His His Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys 
            500                 505                 510         


Phe Asn Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr Lys Ser Lys 
        515                 520                 525             


Phe Leu Gly Met Ser Ile Gly Val His Asn Ile Gly Gln Gly Cys Val 
    530                 535                 540                 


Ser Cys Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe Pro Asn Gly 
545                 550                 555                 560 


Tyr Gly Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu 
                565                 570                 575     


Cys Asn Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe 
            580                 585                 590         


His Thr Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile Thr Ala Glu 
        595                 600                 605             


Ile Phe Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu 
    610                 615                 620                 


Trp Asn Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val 
625                 630                 635                 640 


Phe Val Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys Val Arg Lys 
                645                 650                 655     


Leu Glu Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val 
            660                 665                 670         


Thr Phe Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys 
        675                 680                 685             


His Arg Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu 
    690                 695                 700                 


Lys Glu Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp Gly Glu Cys 
705                 710                 715                 720 


Trp Val Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
                725                 730                 735     


<210>  225
<211>  2847
<212>  DNA
<213>  Homosapiens

<400>  225
ggtgaagggg gtgtcccggg ggacgggctg aacctcagtc aggaccgcct gcaccgcagt     60

ccggggatcg ggtcgagggg agaagaaaaa ggggtgctcg ggagcagccc ccggctacct    120

cccctggagg cacagagggc gggggccttg gcgaatggct ttcttgctgg ccacttgcgg    180

agtgagtaga ccccgagggt ctgggagagg ggccggcccc tacccctgag tccccggggt    240

cccggccgcc aggccggagc gcgaatgtcg tgctcaccct gcctccttcc cgccgccccc    300

tgggggtttg gattcaggat ttgttcctag tgtccaagat tttgataaga aacttacaga    360

agctgatgct tacctacaaa tcttgattga acaattaaag ctttttgatg acaagcttca    420

aaactgcaaa gaagatgaac agagaaagaa aattgaaact ctcaaagaga caacaaatag    480

catggtagaa tcaattaaac actgcattgt gttgctgcag attgccaaaa gtactattaa    540

tcccgtagat gcaatatatc aacctagtcc tttggaacct gtgatcagca caatgccttc    600

ccagactgtg ttacctccag aacctgttca gttgtgtaag tcagagcagc gtccatcttc    660

cctaccagtt ggacctgtgt tggctacctt gggacatcat cagactccta caccaaatag    720

tacaggcagt ggccattcac caccgagtag cagtctcact tctccaagcc acgtgaactt    780

gtctccaaat acagtcccag agttctctta ctccagcagt gaagatgaat tttatgatgc    840

tgatgaattc catcaaagtg gctcatcccc aaagcgctta atagattctt ctggatctgc    900

ctcagtcctg acacacagca gctcgggaaa tagtctaaaa cgcccagata ccacagaatc    960

acttaattct tccttgtcca atggaacaag tgatgctgac ctgtttgatt cacatgatga   1020

cagagatgat gatgcggagg cagggtctgt ggaggagcac aagagcgtta tcatgcatct   1080

cttgtcgcag gttagacttg gaatggatct tactaaggta gttcttccaa cgtttattct   1140

tgaaagaaga tctcttttag aaatgtatgc agactttttt gcacatccgg acctgtttgt   1200

gagcattagt gaccagaagg atcccaagga tcgaatggtt caggttgtga aatggtacct   1260

ctcagccttt catgcgggaa ggaaaggatc agttgccaaa aagccataca atcccatttt   1320

gggcgagatt tttcagtgtc attggacatt accaaatgat actgaagaga acacagaact   1380

agtttcagaa ggaccagttc cctgggtttc caaaaacagt gtaacatttg tggctgagca   1440

ggtttcccat catccaccca tttcagcctt ttatgctgag tgttttaaca agaagataca   1500

attcaatgct catatctgga ccaaatcaaa attccttggg atgtcaattg gggtgcacaa   1560

catagggcag ggctgtgtct catgtctaga ctatgatgaa cattacattc tcacattccc   1620

caatggctat ggaaggtcta tcctcacagt gccctgggtg gaattaggag gagaatgcaa   1680

tattaattgt tccaaaacag gctatagtgc aaatatcatc ttccacacta aacccttcta   1740

tgggggcaag aagcacagaa ttactgccga gattttttct ccaaatgaca agaagtcttt   1800

ttgctcaatt gaaggggaat ggaatggtgt gatgtatgca aaatatgcaa caggggaaaa   1860

tacagtcttt gtagatacca agaagttgcc tataatcaag aagaaagtga ggaagttgga   1920

agatcagaac gagtatgaat cccgcagcct ttggaaggat gtcactttca acttaaaaat   1980

cagagacatt gatgcagcaa ctgaagcaaa gcacaggctt gaagaaagac aaagagcaga   2040

agcccgagaa aggaaggaga aggaaattca gtgggagaca aggttatttc atgaagatgg   2100

agaatgctgg gtttatgatg aaccattact gaaacgtctt ggtgctgcca agcattaggt   2160

tggaagatgc aaagtttata cctgatgatc agggcagtag gcataattca gcaacaaaca   2220

atcttccttt gggagaaacc tgttcattcc aatcttctaa ttacagtggt tcctatctca   2280

gggatactgg actttctgac gcagatgaac aattaagggg aaaagcttcc cttttccctc   2340

tgtggcagtt acgattttga cttcagtcct gagaaaaact tcaggttttg aaaatcagat   2400

gatgtcttct ccttttccaa acaccacacg ttgaaagcat ttataaatcc aagtctgaaa   2460

ctctgcgctc tagtactgct gttaagatac acaacttgtt tcttagttca tataatctcg   2520

ggatacacac acacacacac atatatatac acacacatac gtatacacac acatacatat   2580

atataaatat acctgatgcc agattttttt cataaatatt ctgcctactg taaatatggg   2640

ttcctctgag ttgttttaga aaattagcgc aatgtattaa aatcaagtgt taggaaattt   2700

catggtctta cctacaataa cttttatttt ggaattgaac tattattaaa ttgtatctaa   2760

tcctggatta cagtttaatt aattattctt agtgcttaag gcttcataaa gtaatttttc   2820

caaccttttt tttaaaaaaa aaaaaaa                                       2847


<210>  226
<211>  558
<212>  PRT
<213>  Homosapiens

<400>  226

Met Val Glu Ser Ile Lys His Cys Ile Val Leu Leu Gln Ile Ala Lys 
1               5                   10                  15      


Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro Leu Glu 
            20                  25                  30          


Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro 
        35                  40                  45              


Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly 
    50                  55                  60                  


Pro Val Leu Ala Thr Leu Gly His His Gln Thr Pro Thr Pro Asn Ser 
65                  70                  75                  80  


Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser 
                85                  90                  95      


His Val Asn Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser 
            100                 105                 110         


Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser 
        115                 120                 125             


Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr 
    130                 135                 140                 


His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser 
145                 150                 155                 160 


Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp 
                165                 170                 175     


Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu 
            180                 185                 190         


His Lys Ser Val Ile Met His Leu Leu Ser Gln Val Arg Leu Gly Met 
        195                 200                 205             


Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser 
    210                 215                 220                 


Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val 
225                 230                 235                 240 


Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg Met Val Gln Val Val 
                245                 250                 255     


Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala 
            260                 265                 270         


Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp 
        275                 280                 285             


Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly 
    290                 295                 300                 


Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln 
305                 310                 315                 320 


Val Ser His His Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn 
                325                 330                 335     


Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu 
            340                 345                 350         


Gly Met Ser Ile Gly Val His Asn Ile Gly Gln Gly Cys Val Ser Cys 
        355                 360                 365             


Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly 
    370                 375                 380                 


Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn 
385                 390                 395                 400 


Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr 
                405                 410                 415     


Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe 
            420                 425                 430         


Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn 
        435                 440                 445             


Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val 
    450                 455                 460                 


Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu 
465                 470                 475                 480 


Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe 
                485                 490                 495     


Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg 
            500                 505                 510         


Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu 
        515                 520                 525             


Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val 
    530                 535                 540                 


Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
545                 550                 555             


<210>  227
<211>  2751
<212>  DNA
<213>  Homosapiens

<400>  227
ggtgaagggg gtgtcccggg ggacgggctg aacctcagtc aggaccgcct gcaccgcagt     60

ccggggatcg ggtcgagggg agaagaaaaa ggggtgctcg ggagcagccc ccggctacct    120

cccctggagg cacagagggc gggggccttg gcgaatggct ttcttgctgg ccacttgcgg    180

agtgagtaga ccccgagggt ctgggagagg ggccggcccc tacccctgag tccccggggt    240

cccggccgcc aggccggagc gcgaatgtcg tgctcaccct gcctccttcc cgccgccccc    300

tgggcttttt gatgacaagc ttcaaaactg caaagaagat gaacagagaa agaaaattga    360

aactctcaaa gagacaacaa atagcatggt agaatcaatt aaacactgca ttgtgttgct    420

gcagattgcc aaaagtacta ttaatcccgt agatgcaata tatcaaccta gtcctttgga    480

acctgtgatc agcacaatgc cttcccagac tgtgttacct ccagaacctg ttcagttgtg    540

taagtcagag cagcgtccat cttccctacc agttggacct gtgttggcta ccttgggaca    600

tcatcagact cctacaccaa atagtacagg cagtggccat tcaccaccga gtagcagtct    660

cacttctcca agccacgtga acttgtctcc aaatacagtc ccagagttct cttactccag    720

cagtgaagat gaattttatg atgctgatga attccatcaa agtggctcat ccccaaagcg    780

cttaatagat tcttctggat ctgcctcagt cctgacacac agcagctcgg gaaatagtct    840

aaaacgccca gataccacag aatcacttaa ttcttccttg tccaatggaa caagtgatgc    900

tgacctgttt gattcacatg atgacagaga tgatgatgcg gaggcagggt ctgtggagga    960

gcacaagagc gttatcatgc atctcttgtc gcaggttaga cttggaatgg atcttactaa   1020

ggtagttctt ccaacgttta ttcttgaaag aagatctctt ttagaaatgt atgcagactt   1080

ttttgcacat ccggacctgt ttgtgagcat tagtgaccag aaggatccca aggatcgaat   1140

ggttcaggtt gtgaaatggt acctctcagc ctttcatgcg ggaaggaaag gatcagttgc   1200

caaaaagcca tacaatccca ttttgggcga gatttttcag tgtcattgga cattaccaaa   1260

tgatactgaa gagaacacag aactagtttc agaaggacca gttccctggg tttccaaaaa   1320

cagtgtaaca tttgtggctg agcaggtttc ccatcatcca cccatttcag ccttttatgc   1380

tgagtgtttt aacaagaaga tacaattcaa tgctcatatc tggaccaaat caaaattcct   1440

tgggatgtca attggggtgc acaacatagg gcagggctgt gtctcatgtc tagactatga   1500

tgaacattac attctcacat tccccaatgg ctatggaagg tctatcctca cagtgccctg   1560

ggtggaatta ggaggagaat gcaatattaa ttgttccaaa acaggctata gtgcaaatat   1620

catcttccac actaaaccct tctatggggg caagaagcac agaattactg ccgagatttt   1680

ttctccaaat gacaagaagt ctttttgctc aattgaaggg gaatggaatg gtgtgatgta   1740

tgcaaaatat gcaacagggg aaaatacagt ctttgtagat accaagaagt tgcctataat   1800

caagaagaaa gtgaggaagt tggaagatca gaacgagtat gaatcccgca gcctttggaa   1860

ggatgtcact ttcaacttaa aaatcagaga cattgatgca gcaactgaag caaagcacag   1920

gcttgaagaa agacaaagag cagaagcccg agaaaggaag gagaaggaaa ttcagtggga   1980

gacaaggtta tttcatgaag atggagaatg ctgggtttat gatgaaccat tactgaaacg   2040

tcttggtgct gccaagcatt aggttggaag atgcaaagtt tatacctgat gatcagggca   2100

gtaggcataa ttcagcaaca aacaatcttc ctttgggaga aacctgttca ttccaatctt   2160

ctaattacag tggttcctat ctcagggata ctggactttc tgacgcagat gaacaattaa   2220

ggggaaaagc ttcccttttc cctctgtggc agttacgatt ttgacttcag tcctgagaaa   2280

aacttcaggt tttgaaaatc agatgatgtc ttctcctttt ccaaacacca cacgttgaaa   2340

gcatttataa atccaagtct gaaactctgc gctctagtac tgctgttaag atacacaact   2400

tgtttcttag ttcatataat ctcgggatac acacacacac acacatatat atacacacac   2460

atacgtatac acacacatac atatatataa atatacctga tgccagattt ttttcataaa   2520

tattctgcct actgtaaata tgggttcctc tgagttgttt tagaaaatta gcgcaatgta   2580

ttaaaatcaa gtgttaggaa atttcatggt cttacctaca ataactttta ttttggaatt   2640

gaactattat taaattgtat ctaatcctgg attacagttt aattaattat tcttagtgct   2700

taaggcttca taaagtaatt tttccaacct tttttttaaa aaaaaaaaaa a            2751


<210>  228
<211>  558
<212>  PRT
<213>  Homosapiens

<400>  228

Met Val Glu Ser Ile Lys His Cys Ile Val Leu Leu Gln Ile Ala Lys 
1               5                   10                  15      


Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro Leu Glu 
            20                  25                  30          


Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro 
        35                  40                  45              


Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly 
    50                  55                  60                  


Pro Val Leu Ala Thr Leu Gly His His Gln Thr Pro Thr Pro Asn Ser 
65                  70                  75                  80  


Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser 
                85                  90                  95      


His Val Asn Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser 
            100                 105                 110         


Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser 
        115                 120                 125             


Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr 
    130                 135                 140                 


His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser 
145                 150                 155                 160 


Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp 
                165                 170                 175     


Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu 
            180                 185                 190         


His Lys Ser Val Ile Met His Leu Leu Ser Gln Val Arg Leu Gly Met 
        195                 200                 205             


Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser 
    210                 215                 220                 


Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val 
225                 230                 235                 240 


Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg Met Val Gln Val Val 
                245                 250                 255     


Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala 
            260                 265                 270         


Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp 
        275                 280                 285             


Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly 
    290                 295                 300                 


Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln 
305                 310                 315                 320 


Val Ser His His Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn 
                325                 330                 335     


Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu 
            340                 345                 350         


Gly Met Ser Ile Gly Val His Asn Ile Gly Gln Gly Cys Val Ser Cys 
        355                 360                 365             


Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly 
    370                 375                 380                 


Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn 
385                 390                 395                 400 


Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr 
                405                 410                 415     


Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe 
            420                 425                 430         


Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn 
        435                 440                 445             


Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val 
    450                 455                 460                 


Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu 
465                 470                 475                 480 


Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe 
                485                 490                 495     


Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg 
            500                 505                 510         


Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu 
        515                 520                 525             


Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val 
    530                 535                 540                 


Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
545                 550                 555             


<210>  229
<211>  2840
<212>  DNA
<213>  Homosapiens

<400>  229
gtcattggcg gctcccaaga tggcgtccat catggaaggg ccgctgagca aatggactaa     60

cgtgatgaag ggctggcagt accgttggtt cgtgctggac tacaatgcag gactgctctc    120

ctactacacg tccaaggaca aaatgatgag aggctctcgc agaggatgtg ttagactcag    180

acccgtgatg ctgatgagcg agagaagtgg atccatgcct tagaagaaac aattcttcga    240

catactctcc agcttcaagg tttggattca ggatttgttc ctagtgtcca agattttgat    300

aagaaactta cagaagctga tgcttaccta caaatcttga ttgaacaatt aaagcttttt    360

gatgacaagc ttcaaaactg caaagaagat gaacagagaa agaaaattga aactctcaaa    420

gagacaacaa atagcatggt agaatcaatt aaacactgca ttgtgttgct gcagattgcc    480

aaagaccaga gtaatgcgga gaagcacgca gatggaatga taagtactat taatcccgta    540

gatgcaatat atcaacctag tcctttggaa cctgtgatca gcacaatgcc ttcccagact    600

gtgttacctc cagaacctgt tcagttgtgt aagtcagagc agcgtccatc ttccctacca    660

gttggacctg tgttggctac cttgggacat catcagactc ctacaccaaa tagtacaggc    720

agtggccatt caccaccgag tagcagtctc acttctccaa gccacgtgaa cttgtctcca    780

aatacagtcc cagagttctc ttactccagc agtgaagatg aattttatga tgctgatgaa    840

ttccatcaaa gtggctcatc cccaaagcgc ttaatagatt cttctggatc tgcctcagtc    900

ctgacacaca gcagctcggg aaatagtcta aaacgcccag ataccacaga atcacttaat    960

tcttccttgt ccaatggaac aagtgatgct gacctgtttg attcacatga tgacagagat   1020

gatgatgcgg aggcagggtc tgtggaggag cacaagagcg ttatcatgca tctcttgtcg   1080

caggttagac ttggaatgga tcttactaag gtagttcttc caacgtttat tcttgaaaga   1140

agatctcttt tagaaatgta tgcagacttt tttgcacatc cggacctgtt tgtgagcatt   1200

agtgaccaga aggatcccaa ggatcgaatg gttcaggttg tgaaatggta cctctcagcc   1260

tttcatgcgg gaaggaaagg atcagttgcc aaaaagccat acaatcccat tttgggcgag   1320

atttttcagt gtcattggac attaccaaat gatactgaag agaacacaga actagtttca   1380

gaaggaccag ttccctgggt ttccaaaaac agtgtaacat ttgtggctga gcaggtttcc   1440

catcatccac ccatttcagc cttttatgct gagtgtttta acaagaagat acaattcaat   1500

gctcatatct ggaccaaatc aaaattcctt gggatgtcaa ttggggtgca caacataggg   1560

cagggctgtg tctcatgtct agactatgat gaacattaca ttctcacatt ccccaatggc   1620

tatggaaggt ctatcctcac agtgccctgg gtggaattag gaggagaatg caatattaat   1680

tgttccaaaa caggctatag tgcaaatatc atcttccaca ctaaaccctt ctatgggggc   1740

aagaagcaca gaattactgc cgagattttt tctccaaatg acaagaagtc tttttgctca   1800

attgaagggg aatggaatgg tgtgatgtat gcaaaatatg caacagggga aaatacagtc   1860

tttgtagata ccaagaagtt gcctataatc aagaagaaag tgaggaagtt ggaagatcag   1920

aacgagtatg aatcccgcag cctttggaag gatgtcactt tcaacttaaa aatcagagac   1980

attgatgcag caactgaagc aaagcacagg cttgaagaaa gacaaagagc agaagcccga   2040

gaaaggaagg agaaggaaat tcagtgggag acaaggttat ttcatgaaga tggagaatgc   2100

tgggtttatg atgaaccatt actgaaacgt cttggtgctg ccaagcatta ggttggaaga   2160

tgcaaagttt atacctgatg atcagggcag taggcataat tcagcaacaa acaatcttcc   2220

tttgggagaa acctgttcat tccaatcttc taattacagt ggttcctatc tcagggatac   2280

tggactttct gacgcagatg aacaattaag gggaaaagct tcccttttcc ctctgtggca   2340

gttacgattt tgacttcagt cctgagaaaa acttcaggtt ttgaaaatca gatgatgtct   2400

tctccttttc caaacaccac acgttgaaag catttataaa tccaagtctg aaactctgcg   2460

ctctagtact gctgttaaga tacacaactt gtttcttagt tcatataatc tcgggataca   2520

cacacacaca cacatatata tacacacaca tacgtataca cacacataca tatatataaa   2580

tatacctgat gccagatttt tttcataaat attctgccta ctgtaaatat gggttcctct   2640

gagttgtttt agaaaattag cgcaatgtat taaaatcaag tgttaggaaa tttcatggtc   2700

ttacctacaa taacttttat tttggaattg aactattatt aaattgtatc taatcctgga   2760

ttacagttta attaattatt cttagtgctt aaggcttcat aaagtaattt ttccaacctt   2820

ttttttaaaa aaaaaaaaaa                                               2840


<210>  230
<211>  571
<212>  PRT
<213>  Homosapiens

<400>  230

Met Val Glu Ser Ile Lys His Cys Ile Val Leu Leu Gln Ile Ala Lys 
1               5                   10                  15      


Asp Gln Ser Asn Ala Glu Lys His Ala Asp Gly Met Ile Ser Thr Ile 
            20                  25                  30          


Asn Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro Leu Glu Pro Val Ile 
        35                  40                  45              


Ser Thr Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro Val Gln Leu 
    50                  55                  60                  


Cys Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly Pro Val Leu 
65                  70                  75                  80  


Ala Thr Leu Gly His His Gln Thr Pro Thr Pro Asn Ser Thr Gly Ser 
                85                  90                  95      


Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser His Val Asn 
            100                 105                 110         


Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser Ser Glu Asp 
        115                 120                 125             


Glu Phe Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser Ser Pro Lys 
    130                 135                 140                 


Arg Leu Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr His Ser Ser 
145                 150                 155                 160 


Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser Leu Asn Ser 
                165                 170                 175     


Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp Ser His Asp 
            180                 185                 190         


Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu His Lys Ser 
        195                 200                 205             


Val Ile Met His Leu Leu Ser Gln Val Arg Leu Gly Met Asp Leu Thr 
    210                 215                 220                 


Lys Val Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser Leu Leu Glu 
225                 230                 235                 240 


Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val Ser Ile Ser 
                245                 250                 255     


Asp Gln Lys Asp Pro Lys Asp Arg Met Val Gln Val Val Lys Trp Tyr 
            260                 265                 270         


Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala Lys Lys Pro 
        275                 280                 285             


Tyr Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp Thr Leu Pro 
    290                 295                 300                 


Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly Pro Val Pro 
305                 310                 315                 320 


Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln Val Ser His 
                325                 330                 335     


His Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn Lys Lys Ile 
            340                 345                 350         


Gln Phe Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu Gly Met Ser 
        355                 360                 365             


Ile Gly Val His Asn Ile Gly Gln Gly Cys Val Ser Cys Leu Asp Tyr 
    370                 375                 380                 


Asp Glu His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly Arg Ser Ile 
385                 390                 395                 400 


Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn Ile Asn Cys 
                405                 410                 415     


Ser Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr Lys Pro Phe 
            420                 425                 430         


Tyr Gly Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe Ser Pro Asn 
        435                 440                 445             


Asp Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn Gly Val Met 
    450                 455                 460                 


Tyr Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val Asp Thr Lys 
465                 470                 475                 480 


Lys Leu Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu Asp Gln Asn 
                485                 490                 495     


Glu Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe Asn Leu Lys 
            500                 505                 510         


Ile Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg Leu Glu Glu 
        515                 520                 525             


Arg Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu Ile Gln Trp 
    530                 535                 540                 


Glu Thr Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val Tyr Asp Glu 
545                 550                 555                 560 


Pro Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
                565                 570     


<210>  231
<211>  2694
<212>  DNA
<213>  Homosapiens

<400>  231
aacctcagtc aggaccgcct gcaccgcagt ccggggatcg ggtcgagggg agaagaaaaa     60

ggggtgctcg ggagcagccc ccggctacct cccctggagg cacagagggc gggggccttg    120

gcgaatggct ttcttgctgg ccacttgcgg aggtttggat tcaggatttg ttcctagtgt    180

ccaagatttt gataagaaac ttacagaagc tgatgcttac ctacaaatct tgattgaaca    240

attaaagctt tttgatgaca agcttcaaaa ctgcaaagaa gatgaacaga gaaagaaaat    300

tgaaactctc aaagagacaa caaatagcat ggtagaatca attaaacact gcattgtgtt    360

gctgcagatt gccaaaagta ctattaatcc cgtagatgca atatatcaac ctagtccttt    420

ggaacctgtg atcagcacaa tgccttccca gactgtgtta cctccagaac ctgttcagtt    480

gtgtaagtca gagcagcgtc catcttccct accagttgga cctgtgttgg ctaccttggg    540

acatcatcag actcctacac caaatagtac aggcagtggc cattcaccac cgagtagcag    600

tctcacttct ccaagccacg tgaacttgtc tccaaataca gtcccagagt tctcttactc    660

cagcagtgaa gatgaatttt atgatgctga tgaattccat caaagtggct catccccaaa    720

gcgcttaata gattcttctg gatctgcctc agtcctgaca cacagcagct cgggaaatag    780

tctaaaacgc ccagatacca cagaatcact taattcttcc ttgtccaatg gaacaagtga    840

tgctgacctg tttgattcac atgatgacag agatgatgat gcggaggcag ggtctgtgga    900

ggagcacaag agcgttatca tgcatctctt gtcgcaggtt agacttggaa tggatcttac    960

taaggtagtt cttccaacgt ttattcttga aagaagatct cttttagaaa tgtatgcaga   1020

cttttttgca catccggacc tgtttgtgag cattagtgac cagaaggatc ccaaggatcg   1080

aatggttcag gttgtgaaat ggtacctctc agcctttcat gcgggaagga aaggatcagt   1140

tgccaaaaag ccatacaatc ccattttggg cgagattttt cagtgtcatt ggacattacc   1200

aaatgatact gaagagaaca cagaactagt ttcagaagga ccagttccct gggtttccaa   1260

aaacagtgta acatttgtgg ctgagcaggt ttcccatcat ccacccattt cagcctttta   1320

tgctgagtgt tttaacaaga agatacaatt caatgctcat atctggacca aatcaaaatt   1380

ccttgggatg tcaattgggg tgcacaacat agggcagggc tgtgtctcat gtctagacta   1440

tgatgaacat tacattctca cattccccaa tggctatgga aggtctatcc tcacagtgcc   1500

ctgggtggaa ttaggaggag aatgcaatat taattgttcc aaaacaggct atagtgcaaa   1560

tatcatcttc cacactaaac ccttctatgg gggcaagaag cacagaatta ctgccgagat   1620

tttttctcca aatgacaaga agtctttttg ctcaattgaa ggggaatgga atggtgtgat   1680

gtatgcaaaa tatgcaacag gggaaaatac agtctttgta gataccaaga agttgcctat   1740

aatcaagaag aaagtgagga agttggaaga tcagaacgag tatgaatccc gcagcctttg   1800

gaaggatgtc actttcaact taaaaatcag agacattgat gcagcaactg aagcaaagca   1860

caggcttgaa gaaagacaaa gagcagaagc ccgagaaagg aaggagaagg aaattcagtg   1920

ggagacaagg ttatttcatg aagatggaga atgctgggtt tatgatgaac cattactgaa   1980

acgtcttggt gctgccaagc attaggttgg aagatgcaaa gtttatacct gatgatcagg   2040

gcagtaggca taattcagca acaaacaatc ttcctttggg agaaacctgt tcattccaat   2100

cttctaatta cagtggttcc tatctcaggg atactggact ttctgacgca gatgaacaat   2160

taaggggaaa agcttccctt ttccctctgt ggcagttacg attttgactt cagtcctgag   2220

aaaaacttca ggttttgaaa atcagatgat gtcttctcct tttccaaaca ccacacgttg   2280

aaagcattta taaatccaag tctgaaactc tgcgctctag tactgctgtt aagatacaca   2340

acttgtttct tagttcatat aatctcggga tacacacaca cacacacata tatatacaca   2400

cacatacgta tacacacaca tacatatata taaatatacc tgatgccaga tttttttcat   2460

aaatattctg cctactgtaa atatgggttc ctctgagttg ttttagaaaa ttagcgcaat   2520

gtattaaaat caagtgttag gaaatttcat ggtcttacct acaataactt ttattttgga   2580

attgaactat tattaaattg tatctaatcc tggattacag tttaattaat tattcttagt   2640

gcttaaggct tcataaagta atttttccaa cctttttttt aaaaaaaaaa aaaa         2694


<210>  232
<211>  626
<212>  PRT
<213>  Homosapiens

<400>  232

Met Ala Phe Leu Leu Ala Thr Cys Gly Gly Leu Asp Ser Gly Phe Val 
1               5                   10                  15      


Pro Ser Val Gln Asp Phe Asp Lys Lys Leu Thr Glu Ala Asp Ala Tyr 
            20                  25                  30          


Leu Gln Ile Leu Ile Glu Gln Leu Lys Leu Phe Asp Asp Lys Leu Gln 
        35                  40                  45              


Asn Cys Lys Glu Asp Glu Gln Arg Lys Lys Ile Glu Thr Leu Lys Glu 
    50                  55                  60                  


Thr Thr Asn Ser Met Val Glu Ser Ile Lys His Cys Ile Val Leu Leu 
65                  70                  75                  80  


Gln Ile Ala Lys Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln Pro 
                85                  90                  95      


Ser Pro Leu Glu Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val Leu 
            100                 105                 110         


Pro Pro Glu Pro Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser Ser 
        115                 120                 125             


Leu Pro Val Gly Pro Val Leu Ala Thr Leu Gly His His Gln Thr Pro 
    130                 135                 140                 


Thr Pro Asn Ser Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser Leu 
145                 150                 155                 160 


Thr Ser Pro Ser His Val Asn Leu Ser Pro Asn Thr Val Pro Glu Phe 
                165                 170                 175     


Ser Tyr Ser Ser Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe His 
            180                 185                 190         


Gln Ser Gly Ser Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser Ala 
        195                 200                 205             


Ser Val Leu Thr His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro Asp 
    210                 215                 220                 


Thr Thr Glu Ser Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp Ala 
225                 230                 235                 240 


Asp Leu Phe Asp Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala Gly 
                245                 250                 255     


Ser Val Glu Glu His Lys Ser Val Ile Met His Leu Leu Ser Gln Val 
            260                 265                 270         


Arg Leu Gly Met Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile Leu 
        275                 280                 285             


Glu Arg Arg Ser Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His Pro 
    290                 295                 300                 


Asp Leu Phe Val Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg Met 
305                 310                 315                 320 


Val Gln Val Val Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg Lys 
                325                 330                 335     


Gly Ser Val Ala Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile Phe 
            340                 345                 350         


Gln Cys His Trp Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu Leu 
        355                 360                 365             


Val Ser Glu Gly Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr Phe 
    370                 375                 380                 


Val Ala Glu Gln Val Ser His His Pro Pro Ile Ser Ala Phe Tyr Ala 
385                 390                 395                 400 


Glu Cys Phe Asn Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr Lys 
                405                 410                 415     


Ser Lys Phe Leu Gly Met Ser Ile Gly Val His Asn Ile Gly Gln Gly 
            420                 425                 430         


Cys Val Ser Cys Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe Pro 
        435                 440                 445             


Asn Gly Tyr Gly Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu Gly 
    450                 455                 460                 


Gly Glu Cys Asn Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn Ile 
465                 470                 475                 480 


Ile Phe His Thr Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile Thr 
                485                 490                 495     


Ala Glu Ile Phe Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile Glu 
            500                 505                 510         


Gly Glu Trp Asn Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu Asn 
        515                 520                 525             


Thr Val Phe Val Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys Val 
    530                 535                 540                 


Arg Lys Leu Glu Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp Lys 
545                 550                 555                 560 


Asp Val Thr Phe Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr Glu 
                565                 570                 575     


Ala Lys His Arg Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu Arg 
            580                 585                 590         


Lys Glu Lys Glu Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp Gly 
        595                 600                 605             


Glu Cys Trp Val Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala Ala 
    610                 615                 620                 


Lys His 
625     


<210>  233
<211>  2880
<212>  DNA
<213>  Homosapiens

<400>  233
gtcattggcg gctcccaaga tggcgtccat catggaaggg ccgctgagca aatggactaa     60

cgtgatgaag ggctggcagt accgttggtt cgtgctggac tacaatgcag gactgctctc    120

ctactacacg tccaaggaca aaatgatgag aggctctcgc agaggatgtg ttagactcag    180

aggagctgtg attggtatag acgatgagga cgacagcacc ttcacaataa ctgttgatca    240

gaaaaccttc catttccagg cccgtgatgc tgatgagcga gagaagtgga tccatgcctt    300

agaagaaaca attcttcgac atactctcca gcttcaaggt ttggattcag gatttgttcc    360

tagtgtccaa gattttgata agaaacttac agaagctgat gcttacctac aaatcttgat    420

tgaacaatta aagctttttg atgacaagct tcaaaactgc aaagaagatg aacagagaaa    480

gaaaattgaa actctcaaag agacaacaaa tagcatggta gaatcaatta aacactgcat    540

tgtgttgctg cagattgcca aaagtactat taatcccgta gatgcaatat atcaacctag    600

tcctttggaa cctgtgatca gcacaatgcc ttcccagact gtgttacctc cagaacctgt    660

tcagttgtgt aagtcagagc agcgtccatc ttccctacca gttggacctg tgttggctac    720

cttgggacat catcagactc ctacaccaaa tagtacaggc agtggccatt caccaccgag    780

tagcagtctc acttctccaa gccacgtgaa cttgtctcca aatacagtcc cagagttctc    840

ttactccagc agtgaagatg aattttatga tgctgatgaa ttccatcaaa gtggctcatc    900

cccaaagcgc ttaatagatt cttctggatc tgcctcagtc ctgacacaca gcagctcggg    960

aaatagtcta aaacgcccag ataccacaga atcacttaat tcttccttgt ccaatggaac   1020

aagtgatgct gacctgtttg attcacatga tgacagagat gatgatgcgg aggcagggtc   1080

tgtggaggag cacaagagcg ttatcatgca tctcttgtcg caggttagac ttggaatgga   1140

tcttactaag gtagttcttc caacgtttat tcttgaaaga agatctcttt tagaaatgta   1200

tgcagacttt tttgcacatc cggacctgtt tgtgagcatt agtgaccaga aggatcccaa   1260

ggatcgaatg gttcaggttg tgaaatggta cctctcagcc tttcatgcgg gaaggaaagg   1320

atcagttgcc aaaaagccat acaatcccat tttgggcgag atttttcagt gtcattggac   1380

attaccaaat gatactgaag agaacacaga actagtttca gaaggaccag ttccctgggt   1440

ttccaaaaac agtgtaacat ttgtggctga gcaggtttcc catcatccac ccatttcagc   1500

cttttatgct gagtgtttta acaagaagat acaattcaat gctcatatct ggaccaaatc   1560

aaaattcctt gggatgtcaa ttggggtgca caacataggg cagggctgtg tctcatgtct   1620

agactatgat gaacattaca ttctcacatt ccccaatggc tatggaaggt ctatcctcac   1680

agtgccctgg gtggaattag gaggagaatg caatattaat tgttccaaaa caggctatag   1740

tgcaaatatc atcttccaca ctaaaccctt ctatgggggc aagaagcaca gaattactgc   1800

cgagattttt tctccaaatg acaagaagtc tttttgctca attgaagggg aatggaatgg   1860

tgtgatgtat gcaaaatatg caacagggga aaatacagtc tttgtagata ccaagaagtt   1920

gcctataatc aagaagaaag tgaggaagtt ggaagatcag aacgagtatg aatcccgcag   1980

cctttggaag gatgtcactt tcaacttaaa aatcagagac attgatgcag caactgaagc   2040

aaagcacagg cttgaagaaa gacaaagagc agaagcccga gaaaggaagg agaaggaaat   2100

tcagtgggag acaaggttat ttcatgaaga tggagaatgc tgggtttatg atgaaccatt   2160

actgaaacgt cttggtgctg ccaagcatta ggttggaaga tgcaaagttt atacctgatg   2220

atcagggcag taggcataat tcagcaacaa acaatcttcc tttgggagaa acctgttcat   2280

tccaatcttc taattacagt ggttcctatc tcagggatac tggactttct gacgcagatg   2340

aacaattaag gggaaaagct tcccttttcc ctctgtggca gttacgattt tgacttcagt   2400

cctgagaaaa acttcaggtt ttgaaaatca gatgatgtct tctccttttc caaacaccac   2460

acgttgaaag catttataaa tccaagtctg aaactctgcg ctctagtact gctgttaaga   2520

tacacaactt gtttcttagt tcatataatc tcgggataca cacacacaca cacatatata   2580

tacacacaca tacgtataca cacacataca tatatataaa tatacctgat gccagatttt   2640

tttcataaat attctgccta ctgtaaatat gggttcctct gagttgtttt agaaaattag   2700

cgcaatgtat taaaatcaag tgttaggaaa tttcatggtc ttacctacaa taacttttat   2760

tttggaattg aactattatt aaattgtatc taatcctgga ttacagttta attaattatt   2820

cttagtgctt aaggcttcat aaagtaattt ttccaacctt ttttttaaaa aaaaaaaaaa   2880


<210>  234
<211>  723
<212>  PRT
<213>  Homosapiens

<400>  234

Met Ala Ser Ile Met Glu Gly Pro Leu Ser Lys Trp Thr Asn Val Met 
1               5                   10                  15      


Lys Gly Trp Gln Tyr Arg Trp Phe Val Leu Asp Tyr Asn Ala Gly Leu 
            20                  25                  30          


Leu Ser Tyr Tyr Thr Ser Lys Asp Lys Met Met Arg Gly Ser Arg Arg 
        35                  40                  45              


Gly Cys Val Arg Leu Arg Gly Ala Val Ile Gly Ile Asp Asp Glu Asp 
    50                  55                  60                  


Asp Ser Thr Phe Thr Ile Thr Val Asp Gln Lys Thr Phe His Phe Gln 
65                  70                  75                  80  


Ala Arg Asp Ala Asp Glu Arg Glu Lys Trp Ile His Ala Leu Glu Glu 
                85                  90                  95      


Thr Ile Leu Arg His Thr Leu Gln Leu Gln Gly Leu Asp Ser Gly Phe 
            100                 105                 110         


Val Pro Ser Val Gln Asp Phe Asp Lys Lys Leu Thr Glu Ala Asp Ala 
        115                 120                 125             


Tyr Leu Gln Ile Leu Ile Glu Gln Leu Lys Leu Phe Asp Asp Lys Leu 
    130                 135                 140                 


Gln Asn Cys Lys Glu Asp Glu Gln Arg Lys Lys Ile Glu Thr Leu Lys 
145                 150                 155                 160 


Glu Thr Thr Asn Ser Met Val Glu Ser Ile Lys His Cys Ile Val Leu 
                165                 170                 175     


Leu Gln Ile Ala Lys Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln 
            180                 185                 190         


Pro Ser Pro Leu Glu Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val 
        195                 200                 205             


Leu Pro Pro Glu Pro Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser 
    210                 215                 220                 


Ser Leu Pro Val Gly Pro Val Leu Ala Thr Leu Gly His His Gln Thr 
225                 230                 235                 240 


Pro Thr Pro Asn Ser Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser 
                245                 250                 255     


Leu Thr Ser Pro Ser His Val Asn Leu Ser Pro Asn Thr Val Pro Glu 
            260                 265                 270         


Phe Ser Tyr Ser Ser Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe 
        275                 280                 285             


His Gln Ser Gly Ser Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser 
    290                 295                 300                 


Ala Ser Val Leu Thr His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro 
305                 310                 315                 320 


Asp Thr Thr Glu Ser Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp 
                325                 330                 335     


Ala Asp Leu Phe Asp Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala 
            340                 345                 350         


Gly Ser Val Glu Glu His Lys Ser Val Ile Met His Leu Leu Ser Gln 
        355                 360                 365             


Val Arg Leu Gly Met Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile 
    370                 375                 380                 


Leu Glu Arg Arg Ser Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His 
385                 390                 395                 400 


Pro Asp Leu Phe Val Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg 
                405                 410                 415     


Met Val Gln Val Val Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg 
            420                 425                 430         


Lys Gly Ser Val Ala Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile 
        435                 440                 445             


Phe Gln Cys His Trp Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu 
    450                 455                 460                 


Leu Val Ser Glu Gly Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr 
465                 470                 475                 480 


Phe Val Ala Glu Gln Val Ser His His Pro Pro Ile Ser Ala Phe Tyr 
                485                 490                 495     


Ala Glu Cys Phe Asn Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr 
            500                 505                 510         


Lys Ser Lys Phe Leu Gly Met Ser Ile Gly Val His Asn Ile Gly Gln 
        515                 520                 525             


Gly Cys Val Ser Cys Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe 
    530                 535                 540                 


Pro Asn Gly Tyr Gly Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu 
545                 550                 555                 560 


Gly Gly Glu Cys Asn Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn 
                565                 570                 575     


Ile Ile Phe His Thr Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile 
            580                 585                 590         


Thr Ala Glu Ile Phe Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile 
        595                 600                 605             


Glu Gly Glu Trp Asn Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu 
    610                 615                 620                 


Asn Thr Val Phe Val Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys 
625                 630                 635                 640 


Val Arg Lys Leu Glu Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp 
                645                 650                 655     


Lys Asp Val Thr Phe Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr 
            660                 665                 670         


Glu Ala Lys His Arg Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu 
        675                 680                 685             


Arg Lys Glu Lys Glu Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp 
    690                 695                 700                 


Gly Glu Cys Trp Val Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala 
705                 710                 715                 720 


Ala Lys His 
            


<210>  235
<211>  2949
<212>  DNA
<213>  Homosapiens

<400>  235
gtcattggcg gctcccaaga tggcgtccat catggaaggg ccgctgagca aatggactaa     60

cgtgatgaag ggctggcagt accgttggtt cgtgctggac tacaatgcag gactgctctc    120

ctactacacg tccaaggaca aaatgatgag aggctctcgc agaggatgtg ttagactcag    180

aggagctgtg attggtatag acgatgagga cgacagcacc ttcacaataa ctgttgatca    240

gaaaaccttc catttccagg cccgtgatgc tgatgagcga gagaagtgga tccatgcctt    300

agaagaaaca attcttcgac atactctcca gcttcaaatc agtaccacac ttgctttttt    360

ccagtcttct ggtatctctc cagttcttga attttcaaaa ataattggtt tggattcagg    420

atttgttcct agtgtccaag attttgataa gaaacttaca gaagctgatg cttacctaca    480

aatcttgatt gaacaattaa agctttttga tgacaagctt caaaactgca aagaagatga    540

acagagaaag aaaattgaaa ctctcaaaga gacaacaaat agcatggtag aatcaattaa    600

acactgcatt gtgttgctgc agattgccaa aagtactatt aatcccgtag atgcaatata    660

tcaacctagt cctttggaac ctgtgatcag cacaatgcct tcccagactg tgttacctcc    720

agaacctgtt cagttgtgta agtcagagca gcgtccatct tccctaccag ttggacctgt    780

gttggctacc ttgggacatc atcagactcc tacaccaaat agtacaggca gtggccattc    840

accaccgagt agcagtctca cttctccaag ccacgtgaac ttgtctccaa atacagtccc    900

agagttctct tactccagca gtgaagatga attttatgat gctgatgaat tccatcaaag    960

tggctcatcc ccaaagcgct taatagattc ttctggatct gcctcagtcc tgacacacag   1020

cagctcggga aatagtctaa aacgcccaga taccacagaa tcacttaatt cttccttgtc   1080

caatggaaca agtgatgctg acctgtttga ttcacatgat gacagagatg atgatgcgga   1140

ggcagggtct gtggaggagc acaagagcgt tatcatgcat ctcttgtcgc aggttagact   1200

tggaatggat cttactaagg tagttcttcc aacgtttatt cttgaaagaa gatctctttt   1260

agaaatgtat gcagactttt ttgcacatcc ggacctgttt gtgagcatta gtgaccagaa   1320

ggatcccaag gatcgaatgg ttcaggttgt gaaatggtac ctctcagcct ttcatgcggg   1380

aaggaaagga tcagttgcca aaaagccata caatcccatt ttgggcgaga tttttcagtg   1440

tcattggaca ttaccaaatg atactgaaga gaacacagaa ctagtttcag aaggaccagt   1500

tccctgggtt tccaaaaaca gtgtaacatt tgtggctgag caggtttccc atcatccacc   1560

catttcagcc ttttatgctg agtgttttaa caagaagata caattcaatg ctcatatctg   1620

gaccaaatca aaattccttg ggatgtcaat tggggtgcac aacatagggc agggctgtgt   1680

ctcatgtcta gactatgatg aacattacat tctcacattc cccaatggct atggaaggtc   1740

tatcctcaca gtgccctggg tggaattagg aggagaatgc aatattaatt gttccaaaac   1800

aggctatagt gcaaatatca tcttccacac taaacccttc tatgggggca agaagcacag   1860

aattactgcc gagatttttt ctccaaatga caagaagtct ttttgctcaa ttgaagggga   1920

atggaatggt gtgatgtatg caaaatatgc aacaggggaa aatacagtct ttgtagatac   1980

caagaagttg cctataatca agaagaaagt gaggaagttg gaagatcaga acgagtatga   2040

atcccgcagc ctttggaagg atgtcacttt caacttaaaa atcagagaca ttgatgcagc   2100

aactgaagca aagcacaggc ttgaagaaag acaaagagca gaagcccgag aaaggaagga   2160

gaaggaaatt cagtgggaga caaggttatt tcatgaagat ggagaatgct gggtttatga   2220

tgaaccatta ctgaaacgtc ttggtgctgc caagcattag gttggaagat gcaaagttta   2280

tacctgatga tcagggcagt aggcataatt cagcaacaaa caatcttcct ttgggagaaa   2340

cctgttcatt ccaatcttct aattacagtg gttcctatct cagggatact ggactttctg   2400

acgcagatga acaattaagg ggaaaagctt cccttttccc tctgtggcag ttacgatttt   2460

gacttcagtc ctgagaaaaa cttcaggttt tgaaaatcag atgatgtctt ctccttttcc   2520

aaacaccaca cgttgaaagc atttataaat ccaagtctga aactctgcgc tctagtactg   2580

ctgttaagat acacaacttg tttcttagtt catataatct cgggatacac acacacacac   2640

acatatatat acacacacat acgtatacac acacatacat atatataaat atacctgatg   2700

ccagattttt ttcataaata ttctgcctac tgtaaatatg ggttcctctg agttgtttta   2760

gaaaattagc gcaatgtatt aaaatcaagt gttaggaaat ttcatggtct tacctacaat   2820

aacttttatt ttggaattga actattatta aattgtatct aatcctggat tacagtttaa   2880

ttaattattc ttagtgctta aggcttcata aagtaatttt tccaaccttt tttttaaaaa   2940

aaaaaaaaa                                                           2949


<210>  236
<211>  746
<212>  PRT
<213>  Homosapiens

<400>  236

Met Ala Ser Ile Met Glu Gly Pro Leu Ser Lys Trp Thr Asn Val Met 
1               5                   10                  15      


Lys Gly Trp Gln Tyr Arg Trp Phe Val Leu Asp Tyr Asn Ala Gly Leu 
            20                  25                  30          


Leu Ser Tyr Tyr Thr Ser Lys Asp Lys Met Met Arg Gly Ser Arg Arg 
        35                  40                  45              


Gly Cys Val Arg Leu Arg Gly Ala Val Ile Gly Ile Asp Asp Glu Asp 
    50                  55                  60                  


Asp Ser Thr Phe Thr Ile Thr Val Asp Gln Lys Thr Phe His Phe Gln 
65                  70                  75                  80  


Ala Arg Asp Ala Asp Glu Arg Glu Lys Trp Ile His Ala Leu Glu Glu 
                85                  90                  95      


Thr Ile Leu Arg His Thr Leu Gln Leu Gln Ile Ser Thr Thr Leu Ala 
            100                 105                 110         


Phe Phe Gln Ser Ser Gly Ile Ser Pro Val Leu Glu Phe Ser Lys Ile 
        115                 120                 125             


Ile Gly Leu Asp Ser Gly Phe Val Pro Ser Val Gln Asp Phe Asp Lys 
    130                 135                 140                 


Lys Leu Thr Glu Ala Asp Ala Tyr Leu Gln Ile Leu Ile Glu Gln Leu 
145                 150                 155                 160 


Lys Leu Phe Asp Asp Lys Leu Gln Asn Cys Lys Glu Asp Glu Gln Arg 
                165                 170                 175     


Lys Lys Ile Glu Thr Leu Lys Glu Thr Thr Asn Ser Met Val Glu Ser 
            180                 185                 190         


Ile Lys His Cys Ile Val Leu Leu Gln Ile Ala Lys Ser Thr Ile Asn 
        195                 200                 205             


Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro Leu Glu Pro Val Ile Ser 
    210                 215                 220                 


Thr Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro Val Gln Leu Cys 
225                 230                 235                 240 


Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly Pro Val Leu Ala 
                245                 250                 255     


Thr Leu Gly His His Gln Thr Pro Thr Pro Asn Ser Thr Gly Ser Gly 
            260                 265                 270         


His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser His Val Asn Leu 
        275                 280                 285             


Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser Ser Glu Asp Glu 
    290                 295                 300                 


Phe Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser Ser Pro Lys Arg 
305                 310                 315                 320 


Leu Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr His Ser Ser Ser 
                325                 330                 335     


Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser Leu Asn Ser Ser 
            340                 345                 350         


Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp Ser His Asp Asp 
        355                 360                 365             


Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu His Lys Ser Val 
    370                 375                 380                 


Ile Met His Leu Leu Ser Gln Val Arg Leu Gly Met Asp Leu Thr Lys 
385                 390                 395                 400 


Val Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser Leu Leu Glu Met 
                405                 410                 415     


Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val Ser Ile Ser Asp 
            420                 425                 430         


Gln Lys Asp Pro Lys Asp Arg Met Val Gln Val Val Lys Trp Tyr Leu 
        435                 440                 445             


Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala Lys Lys Pro Tyr 
    450                 455                 460                 


Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp Thr Leu Pro Asn 
465                 470                 475                 480 


Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly Pro Val Pro Trp 
                485                 490                 495     


Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln Val Ser His His 
            500                 505                 510         


Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn Lys Lys Ile Gln 
        515                 520                 525             


Phe Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu Gly Met Ser Ile 
    530                 535                 540                 


Gly Val His Asn Ile Gly Gln Gly Cys Val Ser Cys Leu Asp Tyr Asp 
545                 550                 555                 560 


Glu His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly Arg Ser Ile Leu 
                565                 570                 575     


Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn Ile Asn Cys Ser 
            580                 585                 590         


Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr Lys Pro Phe Tyr 
        595                 600                 605             


Gly Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe Ser Pro Asn Asp 
    610                 615                 620                 


Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn Gly Val Met Tyr 
625                 630                 635                 640 


Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val Asp Thr Lys Lys 
                645                 650                 655     


Leu Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu Asp Gln Asn Glu 
            660                 665                 670         


Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe Asn Leu Lys Ile 
        675                 680                 685             


Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg Leu Glu Glu Arg 
    690                 695                 700                 


Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu Ile Gln Trp Glu 
705                 710                 715                 720 


Thr Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val Tyr Asp Glu Pro 
                725                 730                 735     


Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
            740                 745     


<210>  237
<211>  3851
<212>  DNA
<213>  Homosapiens

<400>  237
agactggggt gggggagggg ttcaggcctg ttccccgcgg ctgcggcagc accagggccg     60

gccgccaccg cctctagaac gcggaggagg tgggtcctgg gaagcgggat gtccatcgct    120

ccagcttggt ggtgaatgct gaggagagtc actgttgctg cagtctgtgc cacccggagg    180

aagttgtgtg aggccgggcg ggacgtcgcg gcgctctggg gaatcgaaac gcggggtcgg    240

tgcgaagact ctgctgctgc cagacccttt cctattctgg ccatgcctgg aaggaacaag    300

gcgaagtcta cctgcagctg ccctgacctg cagcccaatg gacaggatct gggcgagaac    360

agccgggttg cccgtctagg agcggatgaa tctgaggaag agggacggag ggggtctctc    420

agtaatgctg gggaccctga gatcgtcaag tctcccagcg accccaagca ataccgatac    480

atcaaattac agaatggcct acaggcactt ctgatttcag acctaagtaa tatggaaggt    540

aaaacaggaa atacaacaga tgatgaagaa gaagaggagg tggaggaaga agaagaagat    600

gatgatgaag attctggagc tgaaatagaa gatgacgatg aagagggttt tgatgatgaa    660

gatgagtttg atgatgaaca tgatgatgat cttgatactg aggataatga attggaagaa    720

ttagaagaga gagcagaagc tagaaaaaaa actactgaaa aacagcaatt gcagagcctg    780

tttttgctgt ggtcaaagct gactgataga ctgtggttta agtcaactta ttcaaaaatg    840

tcttcaaccc tgctggtcga gacaagaaat ctttatgggg tagttggagc tgaaagcagg    900

tctgcacctg ttcagcattt ggcaggatgg caagcggagg agcagcaggg tgaaactgac    960

acagttctgt ctgcagcggc tctttgtgtt ggagttggga gtttcgctga tccagatgac   1020

ctgccggggc tggcacactt tttggagcac atggtattca tgggtagttt gaaatatcca   1080

gatgagaatg gatttgatgc cttcctgaag aagcatgggg gtagtgataa tgcctcaact   1140

gattgtgaac gcactgtctt tcagtttgat gtccagagga agtacttcaa ggaagctctt   1200

gatagatggg cgcagttctt catccaccca ctaatgatca gagatgcaat tgaccgtgaa   1260

gttgaagctg ttgatagtga atatcaactt gcaaggcctt ctgatgcaaa cagaaaggaa   1320

atgttgtttg gaagccttgc tagacctggc catcctatgg gaaaattttt ttggggaaat   1380

gctgagacgc tcaagcatga gccaagaaag aataatattg atacacatgc tagattgaga   1440

gaattctgga tgcgttacta ctcttctcat tacatgactt tagtggttca atccaaagaa   1500

acactggata ctttggaaaa gtgggtgact gaaatcttct ctcagatacc aaacaatggg   1560

ttacccagac caaactttgg ccatttaacg gatccatttg acacaccagc atttaacaaa   1620

ctttatagag ttgttccaat cagaaaaatt catgctctga ccatcacatg ggcacttcct   1680

cctcaacagc aacattacag ggtgaagcca cttcattata tatcctggct ggttggacat   1740

gaaggcaaag gcagcattct ttctttcctt aggaaaaaat gctgggctct tgcactgttt   1800

ggtggaaatg gtgagacagg atttgagcaa aattctactt attcagtgtt cagcatttct   1860

attacattga ctgatgaggg ttatgaacat ttttatgagg ttgcttacac tgtctttctg   1920

tatttaaaaa tgctgcagaa gctaggccca gaaaaaagaa tttttgaaga gattcggaaa   1980

attgaggata atgaatttca ttaccaagaa cagacagatc cagttgagta tgtggaaaac   2040

atgtgtgaga acatgcagct gtacccattg caggacattc tcactggaga tcagcttctt   2100

tttgaataca agccagaagt cattggtgaa gccttgaatc agctagttcc tcaaaaagca   2160

aatcttgttt tactgtctgg tgctaatgag ggaaaatgtg acctcaagga gaaatggttt   2220

ggaactcaat atagtataga agatattgaa aactcttggg ctgaactgtg gaatagtaat   2280

ttcgaattaa atccagatct tcatcttcca gctgaaaaca agtacatagc cacggacttt   2340

acgttgaagg ctttcgattg cccggaaaca gaatacccag ttaaaattgt gaatactcca   2400

caaggttgcc tgtggtataa gaaagacaac aaattcaaaa tccccaaagc atatatacgt   2460

ttccatctaa tttcaccgtt gatacagaaa tctgcagcaa atgtggtcct ctttgatatc   2520

tttgtcaata tccttacgca taaccttgcg gaaccagctt atgaagcaga tgtggcacag   2580

ctggagtata aactggcagc tggagaacat ggtttaatta ttcgagtgaa aggatttaac   2640

cacaaactac ctctactgtt tcagctcatt attgactact tagctgagtt caattccaca   2700

ccagctgtct ttacaatgat aactgagcag ttgaagaaga cctactttaa catcctcatc   2760

aagcctgaga ctttggccaa agatgtacgg cttttaatct tggaatatgc ccgttggtct   2820

atgattgaca agtaccaggc tttgatggac ggcctttccc ttgagtctct gctgagcttc   2880

gtcaaagaat tcaaatccca gctctttgtg gagggcctgg tacaagggaa tgtcacaagc   2940

acagaatcta tggatttcct gaaatatgtt gttgacaaac taaacttcaa gcctctggag   3000

caggagatgc ctgtgcagtt ccaggtggta gagctgccca gtggccacca tctatgcaaa   3060

gtgaaagctc tgaacaaggg tgatgccaac tctgaagtca ctgtgtacta ccagtcaggt   3120

accaggagtc taagagaata tacgcttatg gagctgcttg tgatgcacat ggaagaacct   3180

tgttttgact tccttcgaac caagcagacc cttgggtacc atgtctaccc tacctgtagg   3240

aacacatccg ggattctagg attttctgtc actgtgggga ctcaggcaac caaatacaat   3300

tctgaagttg ttgataagaa gatagaagag tttctttcta gctttgagga gaagattgag   3360

aacctcactg aagaggcatt caacacccag gtcacagctc tcatcaagct gaaggagtgt   3420

gaggataccc accttgggga ggaggtggat aggaactgga atgaagtggt tacacagcag   3480

tacctctttg accgccttgc ccacgagatt gaagcactga agtcattctc aaaatcagac   3540

ctggtcaact ggttcaaggc tcatagaggg ccaggaagta aaatgctcag cgttcatgtt   3600

gttgggtatg ggaagtatga actggaagag gatggatccc cttctagtga ggattcaaat   3660

tcttcttgtg aagtgatgca gctgacctac ctgccaacct ctcctctgct ggcagattgt   3720

atcatcccca ttactgatat cagggctttc acaacaacac tcaaccttct cccctaccat   3780

aaaatagtca aataaataaa ctgcagtcac gttggcctga aaaaaaaaaa aaaaaaaaaa   3840

aaaaaaaaaa a                                                        3851


<210>  238
<211>  1219
<212>  PRT
<213>  Homosapiens

<400>  238

Met Leu Arg Arg Val Thr Val Ala Ala Val Cys Ala Thr Arg Arg Lys 
1               5                   10                  15      


Leu Cys Glu Ala Gly Arg Asp Val Ala Ala Leu Trp Gly Ile Glu Thr 
            20                  25                  30          


Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg Pro Phe Pro Ile Leu 
        35                  40                  45              


Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr Cys Ser Cys Pro Asp 
    50                  55                  60                  


Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn Ser Arg Val Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg Arg Gly Ser Leu Ser 
                85                  90                  95      


Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro Ser Asp Pro Lys Gln 
            100                 105                 110         


Tyr Arg Tyr Ile Lys Leu Gln Asn Gly Leu Gln Ala Leu Leu Ile Ser 
        115                 120                 125             


Asp Leu Ser Asn Met Glu Gly Lys Thr Gly Asn Thr Thr Asp Asp Glu 
    130                 135                 140                 


Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Asp Asp Asp Glu Asp Ser 
145                 150                 155                 160 


Gly Ala Glu Ile Glu Asp Asp Asp Glu Glu Gly Phe Asp Asp Glu Asp 
                165                 170                 175     


Glu Phe Asp Asp Glu His Asp Asp Asp Leu Asp Thr Glu Asp Asn Glu 
            180                 185                 190         


Leu Glu Glu Leu Glu Glu Arg Ala Glu Ala Arg Lys Lys Thr Thr Glu 
        195                 200                 205             


Lys Gln Gln Leu Gln Ser Leu Phe Leu Leu Trp Ser Lys Leu Thr Asp 
    210                 215                 220                 


Arg Leu Trp Phe Lys Ser Thr Tyr Ser Lys Met Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Val Glu Thr Arg Asn Leu Tyr Gly Val Val Gly Ala Glu Ser Arg Ser 
                245                 250                 255     


Ala Pro Val Gln His Leu Ala Gly Trp Gln Ala Glu Glu Gln Gln Gly 
            260                 265                 270         


Glu Thr Asp Thr Val Leu Ser Ala Ala Ala Leu Cys Val Gly Val Gly 
        275                 280                 285             


Ser Phe Ala Asp Pro Asp Asp Leu Pro Gly Leu Ala His Phe Leu Glu 
    290                 295                 300                 


His Met Val Phe Met Gly Ser Leu Lys Tyr Pro Asp Glu Asn Gly Phe 
305                 310                 315                 320 


Asp Ala Phe Leu Lys Lys His Gly Gly Ser Asp Asn Ala Ser Thr Asp 
                325                 330                 335     


Cys Glu Arg Thr Val Phe Gln Phe Asp Val Gln Arg Lys Tyr Phe Lys 
            340                 345                 350         


Glu Ala Leu Asp Arg Trp Ala Gln Phe Phe Ile His Pro Leu Met Ile 
        355                 360                 365             


Arg Asp Ala Ile Asp Arg Glu Val Glu Ala Val Asp Ser Glu Tyr Gln 
    370                 375                 380                 


Leu Ala Arg Pro Ser Asp Ala Asn Arg Lys Glu Met Leu Phe Gly Ser 
385                 390                 395                 400 


Leu Ala Arg Pro Gly His Pro Met Gly Lys Phe Phe Trp Gly Asn Ala 
                405                 410                 415     


Glu Thr Leu Lys His Glu Pro Arg Lys Asn Asn Ile Asp Thr His Ala 
            420                 425                 430         


Arg Leu Arg Glu Phe Trp Met Arg Tyr Tyr Ser Ser His Tyr Met Thr 
        435                 440                 445             


Leu Val Val Gln Ser Lys Glu Thr Leu Asp Thr Leu Glu Lys Trp Val 
    450                 455                 460                 


Thr Glu Ile Phe Ser Gln Ile Pro Asn Asn Gly Leu Pro Arg Pro Asn 
465                 470                 475                 480 


Phe Gly His Leu Thr Asp Pro Phe Asp Thr Pro Ala Phe Asn Lys Leu 
                485                 490                 495     


Tyr Arg Val Val Pro Ile Arg Lys Ile His Ala Leu Thr Ile Thr Trp 
            500                 505                 510         


Ala Leu Pro Pro Gln Gln Gln His Tyr Arg Val Lys Pro Leu His Tyr 
        515                 520                 525             


Ile Ser Trp Leu Val Gly His Glu Gly Lys Gly Ser Ile Leu Ser Phe 
    530                 535                 540                 


Leu Arg Lys Lys Cys Trp Ala Leu Ala Leu Phe Gly Gly Asn Gly Glu 
545                 550                 555                 560 


Thr Gly Phe Glu Gln Asn Ser Thr Tyr Ser Val Phe Ser Ile Ser Ile 
                565                 570                 575     


Thr Leu Thr Asp Glu Gly Tyr Glu His Phe Tyr Glu Val Ala Tyr Thr 
            580                 585                 590         


Val Phe Leu Tyr Leu Lys Met Leu Gln Lys Leu Gly Pro Glu Lys Arg 
        595                 600                 605             


Ile Phe Glu Glu Ile Arg Lys Ile Glu Asp Asn Glu Phe His Tyr Gln 
    610                 615                 620                 


Glu Gln Thr Asp Pro Val Glu Tyr Val Glu Asn Met Cys Glu Asn Met 
625                 630                 635                 640 


Gln Leu Tyr Pro Leu Gln Asp Ile Leu Thr Gly Asp Gln Leu Leu Phe 
                645                 650                 655     


Glu Tyr Lys Pro Glu Val Ile Gly Glu Ala Leu Asn Gln Leu Val Pro 
            660                 665                 670         


Gln Lys Ala Asn Leu Val Leu Leu Ser Gly Ala Asn Glu Gly Lys Cys 
        675                 680                 685             


Asp Leu Lys Glu Lys Trp Phe Gly Thr Gln Tyr Ser Ile Glu Asp Ile 
    690                 695                 700                 


Glu Asn Ser Trp Ala Glu Leu Trp Asn Ser Asn Phe Glu Leu Asn Pro 
705                 710                 715                 720 


Asp Leu His Leu Pro Ala Glu Asn Lys Tyr Ile Ala Thr Asp Phe Thr 
                725                 730                 735     


Leu Lys Ala Phe Asp Cys Pro Glu Thr Glu Tyr Pro Val Lys Ile Val 
            740                 745                 750         


Asn Thr Pro Gln Gly Cys Leu Trp Tyr Lys Lys Asp Asn Lys Phe Lys 
        755                 760                 765             


Ile Pro Lys Ala Tyr Ile Arg Phe His Leu Ile Ser Pro Leu Ile Gln 
    770                 775                 780                 


Lys Ser Ala Ala Asn Val Val Leu Phe Asp Ile Phe Val Asn Ile Leu 
785                 790                 795                 800 


Thr His Asn Leu Ala Glu Pro Ala Tyr Glu Ala Asp Val Ala Gln Leu 
                805                 810                 815     


Glu Tyr Lys Leu Ala Ala Gly Glu His Gly Leu Ile Ile Arg Val Lys 
            820                 825                 830         


Gly Phe Asn His Lys Leu Pro Leu Leu Phe Gln Leu Ile Ile Asp Tyr 
        835                 840                 845             


Leu Ala Glu Phe Asn Ser Thr Pro Ala Val Phe Thr Met Ile Thr Glu 
    850                 855                 860                 


Gln Leu Lys Lys Thr Tyr Phe Asn Ile Leu Ile Lys Pro Glu Thr Leu 
865                 870                 875                 880 


Ala Lys Asp Val Arg Leu Leu Ile Leu Glu Tyr Ala Arg Trp Ser Met 
                885                 890                 895     


Ile Asp Lys Tyr Gln Ala Leu Met Asp Gly Leu Ser Leu Glu Ser Leu 
            900                 905                 910         


Leu Ser Phe Val Lys Glu Phe Lys Ser Gln Leu Phe Val Glu Gly Leu 
        915                 920                 925             


Val Gln Gly Asn Val Thr Ser Thr Glu Ser Met Asp Phe Leu Lys Tyr 
    930                 935                 940                 


Val Val Asp Lys Leu Asn Phe Lys Pro Leu Glu Gln Glu Met Pro Val 
945                 950                 955                 960 


Gln Phe Gln Val Val Glu Leu Pro Ser Gly His His Leu Cys Lys Val 
                965                 970                 975     


Lys Ala Leu Asn Lys Gly Asp Ala Asn Ser Glu Val Thr Val Tyr Tyr 
            980                 985                 990         


Gln Ser Gly Thr Arg Ser Leu Arg  Glu Tyr Thr Leu Met  Glu Leu Leu 
        995                 1000                 1005             


Val Met  His Met Glu Glu Pro  Cys Phe Asp Phe Leu  Arg Thr Lys 
    1010                 1015                 1020             


Gln Thr  Leu Gly Tyr His Val  Tyr Pro Thr Cys Arg  Asn Thr Ser 
    1025                 1030                 1035             


Gly Ile  Leu Gly Phe Ser Val  Thr Val Gly Thr Gln  Ala Thr Lys 
    1040                 1045                 1050             


Tyr Asn  Ser Glu Val Val Asp  Lys Lys Ile Glu Glu  Phe Leu Ser 
    1055                 1060                 1065             


Ser Phe  Glu Glu Lys Ile Glu  Asn Leu Thr Glu Glu  Ala Phe Asn 
    1070                 1075                 1080             


Thr Gln  Val Thr Ala Leu Ile  Lys Leu Lys Glu Cys  Glu Asp Thr 
    1085                 1090                 1095             


His Leu  Gly Glu Glu Val Asp  Arg Asn Trp Asn Glu  Val Val Thr 
    1100                 1105                 1110             


Gln Gln  Tyr Leu Phe Asp Arg  Leu Ala His Glu Ile  Glu Ala Leu 
    1115                 1120                 1125             


Lys Ser  Phe Ser Lys Ser Asp  Leu Val Asn Trp Phe  Lys Ala His 
    1130                 1135                 1140             


Arg Gly  Pro Gly Ser Lys Met  Leu Ser Val His Val  Val Gly Tyr 
    1145                 1150                 1155             


Gly Lys  Tyr Glu Leu Glu Glu  Asp Gly Ser Pro Ser  Ser Glu Asp 
    1160                 1165                 1170             


Ser Asn  Ser Ser Cys Glu Val  Met Gln Leu Thr Tyr  Leu Pro Thr 
    1175                 1180                 1185             


Ser Pro  Leu Leu Ala Asp Cys  Ile Ile Pro Ile Thr  Asp Ile Arg 
    1190                 1195                 1200             


Ala Phe  Thr Thr Thr Leu Asn  Leu Leu Pro Tyr His  Lys Ile Val 
    1205                 1210                 1215             


Lys 
    


<210>  239
<211>  1565
<212>  DNA
<213>  Homosapiens

<400>  239
cctgaccgga ccagaccatc ccgcagcgcc ccgccccggc cccctccgcg ccctcccgac     60

gccaggtcct gccgtcccgc cgaccgtccg ggagcgaacc cgtcgtcccg cactcggagt    120

ccgcgatggc ttcagtgaca gatggtaaaa ctggagtcaa agatgcctct gaccagaatt    180

ttgactacat gtttaaactg cttatcattg gcaacagcag tgttggcaag acctccttcc    240

tcttccgcta tgctgatgac acgttcaccc cagccttcgt tagcaccgtg ggcatcgact    300

tcaaggtgaa gacagtctac cgtcacgaga agcgggtgaa actgcagatc tgggacacag    360

ctgggcagga gcggtaccgg accatcacaa cagcctatta ccgtggggcc atgggcttca    420

ttctgatgta tgacatcacc aatgaagagt ccttcaatgc tgtccaagac tgggctactc    480

agatcaagac ctactcctgg gacaatgcac aagttattct ggtggggaac aagtgtgaca    540

tggaggaaga gagggttgtt cccactgaga agggccagct ccttgcagag cagcttgggt    600

ttgatttctt tgaagccagt gcaaaggaga acatcagtgt aaggcaggcc tttgagcgcc    660

tggtggatgc catttgtgac aagatgtctg attcgctgga cacagacccg tcgatgctgg    720

gctcctccaa gaacacgcgt ctctcggaca ccccaccgct gctgcagcag aactgctcat    780

gctaggcaag gcccaccttc ctgacctccc ctcattgtgg ccccacaccc agtctgcttc    840

tccctgttac acactgtccg ctctcagccc actctccctg ttacacactg cccacactca    900

gagcaagatg agttgctgct attctttgcc tgcccctggg gttctctgca gatggtccca    960

gtaatagata ctcagcacta gactaacata acaggtcact acacgggtgc agaatcactt   1020

tacaaaagaa gactctgttt tacgaagggg attcactaca gggacttaga gaacagtctc   1080

ttttctgcct ttaaaatgag agttcctcca tttaccaaaa tttgacacgc acacattctt   1140

caggggcatg ccaattgcgt aaagtgaggc tcgcctgcat agctaatcct gttaaagaca   1200

acttctcaaa gcacaacgtg cttgtttcct atcgggctcc ctgcggggct ttctctcact   1260

acaagtcaag cttgggctct caaagccctg cgcctgttac cacggatgcc cacagggcct   1320

gggcagttgc tgtggcgaca ggaagagcta atcttcagag agctcagact ctctaatgat   1380

gctgaaggag caaaggctga gtcagaaaca cacttaagag aaaaggattg gccgggcgcg   1440

gtggctcacg cctgtaatcc cagcactttg ggaggccgag gcgggtggat catgaggtca   1500

ggagatcgag accatcctgg ctaacaaggt gaaaccccgt ctctactaaa aaaaaaaaaa   1560

aaaaa                                                               1565


<210>  240
<211>  219
<212>  PRT
<213>  Homosapiens

<400>  240

Met Ala Ser Val Thr Asp Gly Lys Thr Gly Val Lys Asp Ala Ser Asp 
1               5                   10                  15      


Gln Asn Phe Asp Tyr Met Phe Lys Leu Leu Ile Ile Gly Asn Ser Ser 
            20                  25                  30          


Val Gly Lys Thr Ser Phe Leu Phe Arg Tyr Ala Asp Asp Thr Phe Thr 
        35                  40                  45              


Pro Ala Phe Val Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Val 
    50                  55                  60                  


Tyr Arg His Glu Lys Arg Val Lys Leu Gln Ile Trp Asp Thr Ala Gly 
65                  70                  75                  80  


Gln Glu Arg Tyr Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met 
                85                  90                  95      


Gly Phe Ile Leu Met Tyr Asp Ile Thr Asn Glu Glu Ser Phe Asn Ala 
            100                 105                 110         


Val Gln Asp Trp Ala Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala 
        115                 120                 125             


Gln Val Ile Leu Val Gly Asn Lys Cys Asp Met Glu Glu Glu Arg Val 
    130                 135                 140                 


Val Pro Thr Glu Lys Gly Gln Leu Leu Ala Glu Gln Leu Gly Phe Asp 
145                 150                 155                 160 


Phe Phe Glu Ala Ser Ala Lys Glu Asn Ile Ser Val Arg Gln Ala Phe 
                165                 170                 175     


Glu Arg Leu Val Asp Ala Ile Cys Asp Lys Met Ser Asp Ser Leu Asp 
            180                 185                 190         


Thr Asp Pro Ser Met Leu Gly Ser Ser Lys Asn Thr Arg Leu Ser Asp 
        195                 200                 205             


Thr Pro Pro Leu Leu Gln Gln Asn Cys Ser Cys 
    210                 215                 


<210>  241
<211>  1616
<212>  DNA
<213>  Homosapiens

<400>  241
cgggacctgg acacccagaa tccacgaaaa gcaactcgcg ctcgagaaca gctctcgtac     60

ccttctacgt gatctgcacc tttaagctca ctccatccca aaccggaccc cggaggcacc    120

acccacatcc gtctaacatc acttccttca gagtttgaaa aaaaaaaatc tgggaagtag    180

aggtgttgtg ctgagcggcg ctcggcgaac tgtgtggacc gtctgctggg actccggccc    240

tgcgtccgct cagccccgtg gccccgcgca cctactgcca tggagacgcg gcctcgtctc    300

ggggccacct gtttgctggg cttcagtttc ctgctcctcg tcatctcttc tgatggacat    360

aatgggcttg gaaagggttt tggagatcat attcattgga ggacactgga agatgggaag    420

aaagaagcag ctgccagtgg actgcccctg atggtgatta ttcataaatc ctggtgtgga    480

gcttgcaaag ctctaaagcc caaatttgca gaatctacgg aaatttcaga actctcccat    540

aattttgtta tggtaaatct tgaggatgaa gaggaaccca aagatgaaga tttcagccct    600

gacgggggtt atattccacg aatccttttt ctggatccca gtggcaaggt gcatcctgaa    660

atcatcaatg agaatggaaa ccccagctac aagtattttt atgtcagtgc cgagcaagtt    720

gttcagggga tgaaggaagc tcaggaaagg ctgacgggtg atgccttcag aaagaaacat    780

cttgaagatg aattgtaaca tgaatgtgcc ccttctttca tcagagttag tgttctggaa    840

ggaaagcagc agggaaggga atattgagga atcatctaga acaattaagc cgaccaggaa    900

acctcattcc tacctacact ggaaggagcg ctctcactgt ggaagagttc tgctaacaga    960

agctggtctg catgtttgtg gatccagcgg agagtggcag actttcttct ccttttccct   1020

ctcacctaaa tgtcaacttg tcattgaatg taaagaatga aaccttctga cacaaaactt   1080

gagccacttg gatgtttact cctcgcactt aagtatttga gtcttttccc atttcctccc   1140

actttactca ccttagtggt gaaaggagac tagtagcatc ttttctacaa cgttaaaatt   1200

gcagaagtag cttatcatta aaaaacaaca acaacaacaa taacaataaa tcctaagtgt   1260

aaatcagtta ttctaccccc taccaaggat atcagcctgt tttttccctt ttttctcctg   1320

ggaataattg tgggcttctt cccaaatttc tacagcctct ttcctcttct catgcttgag   1380

cttccctgtt tgcacgcatg cgtgtgcagg actggctgtg tgcttggact cggctccagg   1440

tggaagcatg ctttcccttg ttactgttgg agaaactcaa accttcaagc cctaggtgta   1500

gccattttgt caagtcatca actgtatttt tgtactggca ttaacaaaaa aagagataaa   1560

atattgtacc attaaacttt aataaaactt taaaaggaaa aaaaaaaaaa aaaaaa       1616


<210>  242
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  242

Met Glu Thr Arg Pro Arg Leu Gly Ala Thr Cys Leu Leu Gly Phe Ser 
1               5                   10                  15      


Phe Leu Leu Leu Val Ile Ser Ser Asp Gly His Asn Gly Leu Gly Lys 
            20                  25                  30          


Gly Phe Gly Asp His Ile His Trp Arg Thr Leu Glu Asp Gly Lys Lys 
        35                  40                  45              


Glu Ala Ala Ala Ser Gly Leu Pro Leu Met Val Ile Ile His Lys Ser 
    50                  55                  60                  


Trp Cys Gly Ala Cys Lys Ala Leu Lys Pro Lys Phe Ala Glu Ser Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Leu Ser His Asn Phe Val Met Val Asn Leu Glu Asp 
                85                  90                  95      


Glu Glu Glu Pro Lys Asp Glu Asp Phe Ser Pro Asp Gly Gly Tyr Ile 
            100                 105                 110         


Pro Arg Ile Leu Phe Leu Asp Pro Ser Gly Lys Val His Pro Glu Ile 
        115                 120                 125             


Ile Asn Glu Asn Gly Asn Pro Ser Tyr Lys Tyr Phe Tyr Val Ser Ala 
    130                 135                 140                 


Glu Gln Val Val Gln Gly Met Lys Glu Ala Gln Glu Arg Leu Thr Gly 
145                 150                 155                 160 


Asp Ala Phe Arg Lys Lys His Leu Glu Asp Glu Leu 
                165                 170         


<210>  243
<211>  1712
<212>  DNA
<213>  Homosapiens

<400>  243
ttggcgcagc gcggttgcca atggtcgctc cctgagagga tgccgctcgt ggtgttttgc     60

gggctgccgt acagcggcaa gagccggcgt gctgaagagt tgcgcgtggc gctggctgcc    120

gagggccgcg cggtgtacgt ggtggacgac gcagctgtcc tgggcgcaga ggacccagcg    180

gtgtacggcg attctgcccg tgagaaggca ttgcgtggag ctctgcgagc ctccgtggaa    240

cggcgcctga gtcgccacga cgtggtcatc ctggactcgc ttaactacat caaaggtttc    300

cgttacgagc tctactgcct ggcacgggcg gcgcgcaccc cgctctgcct ggtctactgc    360

gtacggcccg gcggcccgat cgcgggacct caggtggcgg gcgcgaacga gaaccctggc    420

cggaacgtca gtgtgagttg gcggccacgc gctgaggagg acgggagagc ccaggcggcg    480

ggcagcagcg tcctcaggga actgcatact gcggactctg tagtaaatgg aagtgcccag    540

gccgacgtac ccaaggaact ggagcgagaa gaatccgggg ctgcggagtc tccagctctt    600

gtgactccgg attcagagaa atctgcaaag catgggtccg gtgcctttta ctctcccgaa    660

ctcctggagg ccctaacgct gcgctttgag gctcccgatt ctcggaatcg ctgggaccgg    720

cctttattca ctttggtggg cctagaggag ccgttgcccc tggcggggat ccgctctgcc    780

ctgtttgaga accgggcccc accaccccat cagtctacgc agtcccagcc cctcgcctcc    840

ggcagctttc tgcaccagtt ggaccaggtc acgagtcaag tactggccgg attgatggaa    900

gcgcagaaga gcgctgtccc cggggacttg ctcacgcttc ctggtaccac agagcacttg    960

cggtttaccc ggcccttgac catggcagaa ctgagtcgcc ttcgtcgcca gtttatttcg   1020

tacactaaaa tgcatcccaa caatgagaac ttgccgcaac tggccaacat gtttcttcag   1080

tatttgagcc agagcctgca ctgaccagag gaggtagggg ggaagccatg gcttctgatc   1140

tccactccac tttatttctc tgggaaaaat aggctgcagg tctccagagc atatcgatgc   1200

agtactgtac tagagctgtt gtgactgatt cactcaaact ttcctgcata cccctgtgcc   1260

aggccttggg tttacagcat aagttcagac taaagagaat ggagaactat tgtggtgcaa   1320

cctggcaaat ccctcagagg acagagctaa ggtggacagg gattacctag attggatcct   1380

acttgggcta tcacagagca ttgaccattg gcttccctca tctgaggcgt gggagagcag   1440

actggataga tgagaattgt tttaaaacaa ttgtgaacag aaactgaaga tggtacagtt   1500

ctacatctgc acctgccctt ttttcatacc acaaaagtat tttttgagta ctgtactgac   1560

tttttgctag tttctattct gggaccgagt tcacagataa atccattggt ttgtatcctt   1620

gagaaacttt gtttttgtgg aagtaagaaa gttatctact agattatttc ctctaataaa   1680

atcttttaaa atagtcaaaa aaaaaaaaaa aa                                 1712


<210>  244
<211>  354
<212>  PRT
<213>  Homosapiens

<400>  244

Met Pro Leu Val Val Phe Cys Gly Leu Pro Tyr Ser Gly Lys Ser Arg 
1               5                   10                  15      


Arg Ala Glu Glu Leu Arg Val Ala Leu Ala Ala Glu Gly Arg Ala Val 
            20                  25                  30          


Tyr Val Val Asp Asp Ala Ala Val Leu Gly Ala Glu Asp Pro Ala Val 
        35                  40                  45              


Tyr Gly Asp Ser Ala Arg Glu Lys Ala Leu Arg Gly Ala Leu Arg Ala 
    50                  55                  60                  


Ser Val Glu Arg Arg Leu Ser Arg His Asp Val Val Ile Leu Asp Ser 
65                  70                  75                  80  


Leu Asn Tyr Ile Lys Gly Phe Arg Tyr Glu Leu Tyr Cys Leu Ala Arg 
                85                  90                  95      


Ala Ala Arg Thr Pro Leu Cys Leu Val Tyr Cys Val Arg Pro Gly Gly 
            100                 105                 110         


Pro Ile Ala Gly Pro Gln Val Ala Gly Ala Asn Glu Asn Pro Gly Arg 
        115                 120                 125             


Asn Val Ser Val Ser Trp Arg Pro Arg Ala Glu Glu Asp Gly Arg Ala 
    130                 135                 140                 


Gln Ala Ala Gly Ser Ser Val Leu Arg Glu Leu His Thr Ala Asp Ser 
145                 150                 155                 160 


Val Val Asn Gly Ser Ala Gln Ala Asp Val Pro Lys Glu Leu Glu Arg 
                165                 170                 175     


Glu Glu Ser Gly Ala Ala Glu Ser Pro Ala Leu Val Thr Pro Asp Ser 
            180                 185                 190         


Glu Lys Ser Ala Lys His Gly Ser Gly Ala Phe Tyr Ser Pro Glu Leu 
        195                 200                 205             


Leu Glu Ala Leu Thr Leu Arg Phe Glu Ala Pro Asp Ser Arg Asn Arg 
    210                 215                 220                 


Trp Asp Arg Pro Leu Phe Thr Leu Val Gly Leu Glu Glu Pro Leu Pro 
225                 230                 235                 240 


Leu Ala Gly Ile Arg Ser Ala Leu Phe Glu Asn Arg Ala Pro Pro Pro 
                245                 250                 255     


His Gln Ser Thr Gln Ser Gln Pro Leu Ala Ser Gly Ser Phe Leu His 
            260                 265                 270         


Gln Leu Asp Gln Val Thr Ser Gln Val Leu Ala Gly Leu Met Glu Ala 
        275                 280                 285             


Gln Lys Ser Ala Val Pro Gly Asp Leu Leu Thr Leu Pro Gly Thr Thr 
    290                 295                 300                 


Glu His Leu Arg Phe Thr Arg Pro Leu Thr Met Ala Glu Leu Ser Arg 
305                 310                 315                 320 


Leu Arg Arg Gln Phe Ile Ser Tyr Thr Lys Met His Pro Asn Asn Glu 
                325                 330                 335     


Asn Leu Pro Gln Leu Ala Asn Met Phe Leu Gln Tyr Leu Ser Gln Ser 
            340                 345                 350         


Leu His 
        


<210>  245
<211>  1923
<212>  DNA
<213>  Homosapiens

<400>  245
cttcctcctc ctggccgctt agtctcacac ccgccgggcc gttgttcccg agacgttgtt     60

gagtcccctg tgtcctcttc tgggtggagg aactgcaatg tctggtggag aacagaaacc    120

agagaggtac tatgtgggtg tggacgttgg aacaggcagt gtccgtgcag ctctggtgga    180

ccagagtggg gtcctgttgg cttttgcaga ccagccaatt aagaattggg agccccagtt    240

caaccaccat gagcagtcct ccgaggacat ctgggctgcg tgctgtgttg tcacaaagaa    300

agttgtacaa gggattgatt taaaccaaat tcgaggactt gggtttgatg ccacgtgttc    360

tctggttgtt ttggataagc agtttcaccc attaccagtc aaccaggaag gggattccca    420

tcgaaacgtc atcatgtggc tggaccatcg agcagtcagt caagttaaca ggatcaatga    480

gaccaagcac agtgtcctcc agtacgtcgg gggggtgatg tctgtggaaa tgcaggcccc    540

gaaacttctg tggctgaaag agaacttgag agagatttgc tgggataagg cgggacattt    600

ctttgatctc ccggacttct tatcgtggaa ggcaacaggt gtcacagcac ggtctctctg    660

ctccctggtg tgtaagtgga catattcagc agagaaaggc tgggacgaca gtttctggaa    720

aatgattggt ttggaagact ttgttgcaga taattacagc aaaataggaa accaagtgct    780

acctcctgga gcttctcttg gaaatgggct cacaccagag gcagcaagag accttggcct    840

tctccctggg attgcggtcg cagcttcact cattgatgcc catgcaggag gactaggagt    900

gattggggca gatgtgagag ggcacggcct catctgtgag gggcagccag tgacgtcacg    960

gctggctgtc atctgtggaa cgtcttcttg tcacatgggg atcagcaaag acccgatttt   1020

tgtaccaggc gtctgggggc cttatttctc agccatggta cctgggttct ggctgaatga   1080

aggtggtcag agcgttactg gaaaattgat agaccacatg gtacaaggcc atgctgcttt   1140

tccagaacta caagtaaagg ccacagccag atgccagagt atatatgcat atttgaacag   1200

tcacctggat ctgattaaga aggctcagcc tgtgggtttc cttactgttg atttacatgt   1260

ttggccagat ttccatggca accggtctcc cttagcagat ctgacactaa agggcatggt   1320

caccggattg aaactgtctc aggaccttga tgatcttgcc attctctacc tggccacagt   1380

tcaagccatt gctttgggga ctcgcttcat tatagaagcc atggaggcag cagggcactc   1440

aatcagtact cttttcctat gtggaggcct cagcaagaat cccctttttg tgcaaatgca   1500

tgcggacatt actggcatgc ctgtggtcct gtcgcaagag gtggagtccg ttcttgtggg   1560

tgctgctgtt ctgggtgcct gtgcctcagg ggatttcgct tctgtacagg aagcaatggc   1620

aaaaatgagc aaagttggga aagttgtgtt cccgagacta caggataaaa aatactatga   1680

taagaaatac caagtattcc tgaagctggt tgaacaccag aaggagtatt tggcgatcat   1740

gaatgatgac tgaacagggc ttgcaggtgc tgatgccaga agcttctgtg ccattgcatt   1800

aaagacttct gtcatttgat ccatgttcaa gacccttgag gtattgtttc atcatttctg   1860

tattgtcttt caataaagaa aacaaacatg tgcaaccaaa aaaaaaaaaa aaaaaaaaaa   1920

aaa                                                                 1923


<210>  246
<211>  439
<212>  PRT
<213>  Homosapiens

<400>  246

Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu 
1               5                   10                  15      


Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu 
            20                  25                  30          


Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile 
        35                  40                  45              


Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser 
    50                  55                  60                  


Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys 
65                  70                  75                  80  


Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys 
                85                  90                  95      


Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly 
            100                 105                 110         


Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro 
        115                 120                 125             


Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala 
    130                 135                 140                 


Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp 
145                 150                 155                 160 


Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg 
                165                 170                 175     


Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys 
            180                 185                 190         


Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met 
        195                 200                 205             


Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys 
    210                 215                 220                 


Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln 
225                 230                 235                 240 


Val Lys Ala Thr Ala Arg Cys Gln Ser Ile Tyr Ala Tyr Leu Asn Ser 
                245                 250                 255     


His Leu Asp Leu Ile Lys Lys Ala Gln Pro Val Gly Phe Leu Thr Val 
            260                 265                 270         


Asp Leu His Val Trp Pro Asp Phe His Gly Asn Arg Ser Pro Leu Ala 
        275                 280                 285             


Asp Leu Thr Leu Lys Gly Met Val Thr Gly Leu Lys Leu Ser Gln Asp 
    290                 295                 300                 


Leu Asp Asp Leu Ala Ile Leu Tyr Leu Ala Thr Val Gln Ala Ile Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Phe Ile Ile Glu Ala Met Glu Ala Ala Gly His Ser 
                325                 330                 335     


Ile Ser Thr Leu Phe Leu Cys Gly Gly Leu Ser Lys Asn Pro Leu Phe 
            340                 345                 350         


Val Gln Met His Ala Asp Ile Thr Gly Met Pro Val Val Leu Ser Gln 
        355                 360                 365             


Glu Val Glu Ser Val Leu Val Gly Ala Ala Val Leu Gly Ala Cys Ala 
    370                 375                 380                 


Ser Gly Asp Phe Ala Ser Val Gln Glu Ala Met Ala Lys Met Ser Lys 
385                 390                 395                 400 


Val Gly Lys Val Val Phe Pro Arg Leu Gln Asp Lys Lys Tyr Tyr Asp 
                405                 410                 415     


Lys Lys Tyr Gln Val Phe Leu Lys Leu Val Glu His Gln Lys Glu Tyr 
            420                 425                 430         


Leu Ala Ile Met Asn Asp Asp 
        435                 


<210>  247
<211>  4352
<212>  DNA
<213>  Homosapiens

<400>  247
cccgggcctc ctcccgcttt ctctctccgc ttcccctgga gcctccgagg agtccgcagc     60

cgctgggcgc ccgggaagat ggcggcggcg gcgggagacg gcggcggcga ggggggcgcg    120

ggcctgggca gcgcggcggg gctggggccg gggccggggc tgcgcgggca gggcccctca    180

gccgaagcgc acgagggcgc cccggacccg atgcccgccg cgctgcaccc tgaggaggtc    240

gccgcgcgac tgcagcggat gcagcgggag ctgagcaacc gcaggaaaat cctggtgaaa    300

aacctgcccc aggacagcaa ctgccaggaa gttcatgatt tgttaaaaga ctatgactta    360

aaatattgtt atgtggacag aaataaacga acagcttttg ttaccttatt gaatggggaa    420

caagcccaga acgcaattca gatgtttcat caatattctt ttagaggaaa agacttaata    480

gtccagcttc agccaacaga tgctttgttg tgtattacca acgtgcccat ttcttttaca    540

tcagaagagt ttgaagaact tgttcgtgct tatggaaata ttgagagatg ttttctggtc    600

tatagtgaag ttactggcca ttccaaaggc tatggatttg tggaatacat gaaaaaggac    660

tttgctgcaa aggctagact ggagctattg ggtagacagt tgggagcatc agcactcttt    720

gcacaatgga tggatgttaa tctattggct tcagagctca ttcattctaa gtgcctttgt    780

attgataaac tccccagtga ctacagggat tcagaagagc tgttgcaaat tttttccagt    840

gtccataaac ctgtgttttg ccagcttgca caggatgaag gtagttacgt tggtggcttt    900

gcagtggttg aatatagcac tgcggagcag gctgaagagg tccagcaggc agcagacggt    960

atgaccatca agggcagcaa agtccaggtt tccttctgtg ctcctggagc gccagggcga   1020

agtacattag cagcattgat agcggctcaa cgtgtgatgc acagtaatca aaagggctta   1080

cttccagagc caaatccagt acaaattatg aaaagtttaa acaaccctgc catgttgcaa   1140

gttcttctac agccccagtt atgtggacga gctgttaaac cagccgttct tggaacacct   1200

cacagcttgc cacatctgat gaatccatcc atctctcctg catttttaca tttgaataaa   1260

gcacatcaga atctttctca tataccactg gcacaacaac aattaatgaa gtttgagaat   1320

attcatacta ataataaacc cggcttactt ggagagcccc cagctgtggt acttcagact   1380

gcactaggga tagggtcagt gcttccattg aaaaaggagt tgggacatca tcatggagaa   1440

gcacataaaa catctagcct gattccaact caaacaacga taacagctgg aatgggcatg   1500

ttaccattct ttccaaatca gcacattgct ggacaggctg ggccagggca cagtaatact   1560

caggagaaac agccagccac ggtgggaatg gcagaaggaa atttctcagg gtcgcagcct   1620

tatcttcaga gctttccaaa ccttgctgct ggaagcttgc tggtgggaca ccataagcag   1680

cagcaaagcc agccaaaagg cacagagata agttcagggg ctgcctctaa gaatcaaact   1740

tcactcttgg gagaaccacc aaaagaaatt cggctcagta aaaatccata cttgaatttg   1800

gcaagtgtgt tgcccagtgt gtgcttatca tcccctgcaa gtaaaaccac tcttcataag   1860

actggaattg caagcagcat tctggatgca atctctcagg gaagtgaatc acaacacgca   1920

ttggaaaagt gcattgctta ttctccacct tttggtgatt atgcacaggt gtcatcttta   1980

agaaatgaaa agcgaggctc atcatatctc atctctgccc cagaaggtgg ttcagtggaa   2040

tgtgttgacc agcattctca gggcacagga gcatattaca tggaaactta cttaaaaaag   2100

aagcgagtat actgagttaa gctctctcct aataaccccc taaggttctc tgcagtatct   2160

ctgctgttca tcgctgcctt aacttcattc aaactagcca tatcctttaa atacgggttt   2220

atagtttccc agaaggaact gtgttgtgca gcaggcagaa atgccaaata aaaaatagca   2280

ataagaagag acatcaattg aggacatttt ccactagagt cagatgcatc ttaatcagtg   2340

tgctaactta caatccattg gagaaactaa caatgttcca atattccttg atttaggact   2400

gggaataatt ctgacaccat atataaaaga agtttgaagc aataaatggg aaacagtgtt   2460

gtttcctgag ccttagaaga atgagtttct tataagccaa tgtgcatttc aatttacttt   2520

ccctagaagt aattgcattt atagattttt aggacttttc ctagaactac aagggtgcaa   2580

gtaccaaatg tgctgatggt aatattataa agatgctcta catgcacact caattacgcc   2640

cacaccagcc atgcaaaatt aaacccggta agagagtgac agtgatgtcc aaggtatcca   2700

ctactaccga tgctttaaga tgttgtttac catttatacc ttctgtgaaa aatagaaggt   2760

attttaagaa aagtaacttt ggtgatctaa taaaagggtt tggcaaacta caccctgggt   2820

ccacatttgg tctaccaccc gcttttgtgc tgcctgcaag ctaagactaa tgtttacatt   2880

tttaaatggt tggaggaaaa aagaaaactt atgacatgaa atttatatga aattcagatt   2940

tcagtgtcca taaataaact tttattggga cgttgccatg ctcattcatt tacgtgttgt   3000

ctgtggcact cttacgctac aagggcagaa ctgattagct tcaacagaga ctgtatggcc   3060

tacaaagacc atatggccta aaatttcaag tatctggcca tttatatata gtttgctgat   3120

ccctgatcta atagcactaa ttctaatagc aactattcct ttcaattcac ctaaagacag   3180

acctttagcc tttagacaga cttgtaagtg gaaaggaaca tgggtttctg tgctcatttc   3240

atagcgtaga ctagtaatga tctaatgact agaatggggc ctattttgat cactaaatgc   3300

cctatttcca caatatagta tagtaaagca gtcaatactg cactttctga tggagtctta   3360

aggagtcaca gtatttataa ccattttgag ctaataagct atacctcact ctctgctttc   3420

tctctctctc tttttgatag tgtgttaggg tgaaaaatca gttatttaac ccaatttact   3480

tgtgaaagaa gttttatctt tatggactat gatgactttt gacatcacca tttcttgaag   3540

accttggtat taaatgcatg agaaaccttt tgccatctag aaatttctaa gtttgtttat   3600

gttataagac tgtaattaat tgatagggaa tttgggatct caatccgggg ctttttgaaa   3660

tcagatcatt aaatatctcg tcactttggg gacttgttat ttttaactat gatgtggata   3720

tcctgtttta attatgaagt ctagaattgg tacatatgtt gtatgctttg taaagaattt   3780

cacttggtct aatttattgc atatactagc ttctgttgga aaatgactga cagctagaaa   3840

gtttaaggta atttctaagt atactaccta taagtaactg ataagaatta ggcatcattc   3900

agtgatatag cagatgacta atgggttttt caggccctgc acttctcttt cccattttcc   3960

tgttgcattc agcctcttca atgcttagtc acacctccac tatagtacaa acaaacaaac   4020

aaacagaaga aaggaaagat ggtgaatttt gcaacagagc tgcaaaaagt cagtcaaagc   4080

aggaagaggt tgaaggaact aaaacaaaca aacaaaggtg tctggactac agcacagtgg   4140

acatgccatc catactggcc tgtgccccgt tatcaatcac tgggcacaac agtgaagaag   4200

tgcaaatcaa gtggtgtttg tttgtttgtt tgtagtaagg accgtaaccc accccttcct   4260

ccccccaaaa ctatactgtt atttttctat gtaagcaaat tgtttgaaat gctttgaaaa   4320

tgaaatctta atattaaaag gcatatgcat gt                                 4352


<210>  248
<211>  678
<212>  PRT
<213>  Homosapiens

<400>  248

Met Ala Ala Ala Ala Gly Asp Gly Gly Gly Glu Gly Gly Ala Gly Leu 
1               5                   10                  15      


Gly Ser Ala Ala Gly Leu Gly Pro Gly Pro Gly Leu Arg Gly Gln Gly 
            20                  25                  30          


Pro Ser Ala Glu Ala His Glu Gly Ala Pro Asp Pro Met Pro Ala Ala 
        35                  40                  45              


Leu His Pro Glu Glu Val Ala Ala Arg Leu Gln Arg Met Gln Arg Glu 
    50                  55                  60                  


Leu Ser Asn Arg Arg Lys Ile Leu Val Lys Asn Leu Pro Gln Asp Ser 
65                  70                  75                  80  


Asn Cys Gln Glu Val His Asp Leu Leu Lys Asp Tyr Asp Leu Lys Tyr 
                85                  90                  95      


Cys Tyr Val Asp Arg Asn Lys Arg Thr Ala Phe Val Thr Leu Leu Asn 
            100                 105                 110         


Gly Glu Gln Ala Gln Asn Ala Ile Gln Met Phe His Gln Tyr Ser Phe 
        115                 120                 125             


Arg Gly Lys Asp Leu Ile Val Gln Leu Gln Pro Thr Asp Ala Leu Leu 
    130                 135                 140                 


Cys Ile Thr Asn Val Pro Ile Ser Phe Thr Ser Glu Glu Phe Glu Glu 
145                 150                 155                 160 


Leu Val Arg Ala Tyr Gly Asn Ile Glu Arg Cys Phe Leu Val Tyr Ser 
                165                 170                 175     


Glu Val Thr Gly His Ser Lys Gly Tyr Gly Phe Val Glu Tyr Met Lys 
            180                 185                 190         


Lys Asp Phe Ala Ala Lys Ala Arg Leu Glu Leu Leu Gly Arg Gln Leu 
        195                 200                 205             


Gly Ala Ser Ala Leu Phe Ala Gln Trp Met Asp Val Asn Leu Leu Ala 
    210                 215                 220                 


Ser Glu Leu Ile His Ser Lys Cys Leu Cys Ile Asp Lys Leu Pro Ser 
225                 230                 235                 240 


Asp Tyr Arg Asp Ser Glu Glu Leu Leu Gln Ile Phe Ser Ser Val His 
                245                 250                 255     


Lys Pro Val Phe Cys Gln Leu Ala Gln Asp Glu Gly Ser Tyr Val Gly 
            260                 265                 270         


Gly Phe Ala Val Val Glu Tyr Ser Thr Ala Glu Gln Ala Glu Glu Val 
        275                 280                 285             


Gln Gln Ala Ala Asp Gly Met Thr Ile Lys Gly Ser Lys Val Gln Val 
    290                 295                 300                 


Ser Phe Cys Ala Pro Gly Ala Pro Gly Arg Ser Thr Leu Ala Ala Leu 
305                 310                 315                 320 


Ile Ala Ala Gln Arg Val Met His Ser Asn Gln Lys Gly Leu Leu Pro 
                325                 330                 335     


Glu Pro Asn Pro Val Gln Ile Met Lys Ser Leu Asn Asn Pro Ala Met 
            340                 345                 350         


Leu Gln Val Leu Leu Gln Pro Gln Leu Cys Gly Arg Ala Val Lys Pro 
        355                 360                 365             


Ala Val Leu Gly Thr Pro His Ser Leu Pro His Leu Met Asn Pro Ser 
    370                 375                 380                 


Ile Ser Pro Ala Phe Leu His Leu Asn Lys Ala His Gln Asn Leu Ser 
385                 390                 395                 400 


His Ile Pro Leu Ala Gln Gln Gln Leu Met Lys Phe Glu Asn Ile His 
                405                 410                 415     


Thr Asn Asn Lys Pro Gly Leu Leu Gly Glu Pro Pro Ala Val Val Leu 
            420                 425                 430         


Gln Thr Ala Leu Gly Ile Gly Ser Val Leu Pro Leu Lys Lys Glu Leu 
        435                 440                 445             


Gly His His His Gly Glu Ala His Lys Thr Ser Ser Leu Ile Pro Thr 
    450                 455                 460                 


Gln Thr Thr Ile Thr Ala Gly Met Gly Met Leu Pro Phe Phe Pro Asn 
465                 470                 475                 480 


Gln His Ile Ala Gly Gln Ala Gly Pro Gly His Ser Asn Thr Gln Glu 
                485                 490                 495     


Lys Gln Pro Ala Thr Val Gly Met Ala Glu Gly Asn Phe Ser Gly Ser 
            500                 505                 510         


Gln Pro Tyr Leu Gln Ser Phe Pro Asn Leu Ala Ala Gly Ser Leu Leu 
        515                 520                 525             


Val Gly His His Lys Gln Gln Gln Ser Gln Pro Lys Gly Thr Glu Ile 
    530                 535                 540                 


Ser Ser Gly Ala Ala Ser Lys Asn Gln Thr Ser Leu Leu Gly Glu Pro 
545                 550                 555                 560 


Pro Lys Glu Ile Arg Leu Ser Lys Asn Pro Tyr Leu Asn Leu Ala Ser 
                565                 570                 575     


Val Leu Pro Ser Val Cys Leu Ser Ser Pro Ala Ser Lys Thr Thr Leu 
            580                 585                 590         


His Lys Thr Gly Ile Ala Ser Ser Ile Leu Asp Ala Ile Ser Gln Gly 
        595                 600                 605             


Ser Glu Ser Gln His Ala Leu Glu Lys Cys Ile Ala Tyr Ser Pro Pro 
    610                 615                 620                 


Phe Gly Asp Tyr Ala Gln Val Ser Ser Leu Arg Asn Glu Lys Arg Gly 
625                 630                 635                 640 


Ser Ser Tyr Leu Ile Ser Ala Pro Glu Gly Gly Ser Val Glu Cys Val 
                645                 650                 655     


Asp Gln His Ser Gln Gly Thr Gly Ala Tyr Tyr Met Glu Thr Tyr Leu 
            660                 665                 670         


Lys Lys Lys Arg Val Tyr 
        675             


<210>  249
<211>  5053
<212>  DNA
<213>  Homosapiens

<400>  249
tgcagacagt gcgggcctgc gcccagtccc ggctgtcctc gccgcgaccc ctcctcagcc     60

ctgggcgcgc gcacgctggg gccccgcggg gctggccgcc tagcgagcct gccggtcgac    120

cccagccagc gcagcgacgg ggcgctgcct ggcccaggcg cacacggaag tgcgcttctc    180

tgaagtagct ttggaaagta gagaagaaaa tccagtttgc ttcttggaga acactggaca    240

gctgaataaa tgcagtatct aaatataaaa gaggactgca atgccatggc tttctgtgct    300

aaaatgagga gctccaagaa gactgaggtg aacctggagg cccctgagcc aggggtggaa    360

gtgatcttct atctgtcgga cagggagccc ctccggctgg gcagtggaga gtacacagca    420

gaggaactgt gcatcagggc tgcacaggca tgccgtatct ctcctctttg tcacaacctc    480

tttgccctgt atgacgagaa caccaagctc tggtatgctc caaatcgcac catcaccgtt    540

gatgacaaga tgtccctccg gctccactac cggatgaggt tctatttcac caattggcat    600

ggaaccaacg acaatgagca gtcagtgtgg cgtcattctc caaagaagca gaaaaatggc    660

tacgagaaaa aaaagattcc agatgcaacc cctctccttg atgccagctc actggagtat    720

ctgtttgctc agggacagta tgatttggtg aaatgcctgg ctcctattcg agaccccaag    780

accgagcagg atggacatga tattgagaac gagtgtctag ggatggctgt cctggccatc    840

tcacactatg ccatgatgaa gaagatgcag ttgccagaac tgcccaagga catcagctac    900

aagcgatata ttccagaaac attgaataag tccatcagac agaggaacct tctcaccagg    960

atgcggataa ataatgtttt caaggatttc ctaaaggaat ttaacaacaa gaccatttgt   1020

gacagcagcg tgtccacgca tgacctgaag gtgaaatact tggctacctt ggaaactttg   1080

acaaaacatt acggtgctga aatatttgag acttccatgt tactgatttc atcagaaaat   1140

gagatgaatt ggtttcattc gaatgacggt ggaaacgttc tctactacga agtgatggtg   1200

actgggaatc ttggaatcca gtggaggcat aaaccaaatg ttgtttctgt tgaaaaggaa   1260

aaaaataaac tgaagcggaa aaaactggaa aataaacaca agaaggatga ggagaaaaac   1320

aagatccggg aagagtggaa caatttttct tacttccctg aaatcactca cattgtaata   1380

aaggagtctg tggtcagcat taacaagcag gacaacaaga aaatggaact gaagctctct   1440

tcccacgagg aggccttgtc ctttgtgtcc ctggtagatg gctacttccg gctcacagca   1500

gatgcccatc attacctctg caccgacgtg gcccccccgt tgatcgtcca caacatacag   1560

aatggctgtc atggtccaat ctgtacagaa tacgccatca ataaattgcg gcaagaagga   1620

agcgaggagg ggatgtacgt gctgaggtgg agctgcaccg actttgacaa catcctcatg   1680

accgtcacct gctttgagaa gtctgagcag gtgcagggtg cccagaagca gttcaagaac   1740

tttcagatcg aggtgcagaa gggccgctac agtctgcacg gttcggaccg cagcttcccc   1800

agcttgggag acctcatgag ccacctcaag aagcagatcc tgcgcacgga taacatcagc   1860

ttcatgctaa aacgctgctg ccagcccaag ccccgagaaa tctccaacct gctggtggct   1920

actaagaaag cccaggagtg gcagcccgtc taccccatga gccagctgag tttcgatcgg   1980

atcctcaaga aggatctggt gcagggcgag caccttggga gaggcacgag aacacacatc   2040

tattctggga ccctgatgga ttacaaggat gacgaaggaa cttctgaaga gaagaagata   2100

aaagtgatcc tcaaagtctt agaccccagc cacagggata tttccctggc cttcttcgag   2160

gcagccagca tgatgagaca ggtctcccac aaacacatcg tgtacctcta tggcgtctgt   2220

gtccgcgacg tggagaatat catggtggaa gagtttgtgg aagggggtcc tctggatctc   2280

ttcatgcacc ggaaaagcga tgtccttacc acaccatgga aattcaaagt tgccaaacag   2340

ctggccagtg ccctgagcta cttggaggat aaagacctgg tccatggaaa tgtgtgtact   2400

aaaaacctcc tcctggcccg tgagggcatc gacagtgagt gtggcccatt catcaagctc   2460

agtgaccccg gcatccccat tacggtgctg tctaggcaag aatgcattga acgaatccca   2520

tggattgctc ctgagtgtgt tgaggactcc aagaacctga gtgtggctgc tgacaagtgg   2580

agctttggaa ccacgctctg ggaaatctgc tacaatggcg agatcccctt gaaagacaag   2640

acgctgattg agaaagagag attctatgaa agccggtgca ggccagtgac accatcatgt   2700

aaggagctgg ctgacctcat gacccgctgc atgaactatg accccaatca gaggcctttc   2760

ttccgagcca tcatgagaga cattaataag cttgaagagc agaatccaga tattgtttca   2820

gaaaaaaaac cagcaactga agtggacccc acacattttg aaaagcgctt cctaaagagg   2880

atccgtgact tgggagaggg ccactttggg aaggttgagc tctgcaggta tgaccccgaa   2940

ggggacaata caggggagca ggtggctgtt aaatctctga agcctgagag tggaggtaac   3000

cacatagctg atctgaaaaa ggaaatcgag atcttaagga acctctatca tgagaacatt   3060

gtgaagtaca aaggaatctg cacagaagac ggaggaaatg gtattaagct catcatggaa   3120

tttctgcctt cgggaagcct taaggaatat cttccaaaga ataagaacaa aataaacctc   3180

aaacagcagc taaaatatgc cgttcagatt tgtaagggga tggactattt gggttctcgg   3240

caatacgttc accgggactt ggcagcaaga aatgtccttg ttgagagtga acaccaagtg   3300

aaaattggag acttcggttt aaccaaagca attgaaaccg ataaggagta ttacaccgtc   3360

aaggatgacc gggacagccc tgtgttttgg tatgctccag aatgtttaat gcaatctaaa   3420

ttttatattg cctctgacgt ctggtctttt ggagtcactc tgcatgagct gctgacttac   3480

tgtgattcag attctagtcc catggctttg ttcctgaaaa tgataggccc aacccatggc   3540

cagatgacag tcacaagact tgtgaatacg ttaaaagaag gaaaacgcct gccgtgccca   3600

cctaactgtc cagatgaggt ttatcaactt atgaggaaat gctgggaatt ccaaccatcc   3660

aatcggacaa gctttcagaa ccttattgaa ggatttgaag cacttttaaa ataagaagca   3720

tgaataacat ttaaattcca cagattatca agtccttctc ctgcaacaaa tgcccaagtc   3780

attttttaaa aatttctaat gaaagaagtt tgtgttctgt ccaaaaagtc actgaactca   3840

tacttcagta catatacatg tataaggcac actgtagtgc ttaatatgtg taaggacttc   3900

ctctttaaat ttggtaccag taacttagtg acacataatg acaaccaaaa tatttgaaag   3960

cacttaagca ctcctccttg tggaaagaat ataccaccat ttcatctggc tagttcacca   4020

tcacaactgc attaccaaaa ggggattttt gaaaacgagg agttgaccaa aataatatct   4080

gaagatgatt gcttttccct gctgccagct gatctgaaat gttttgctgg cacattaatc   4140

atagataaag aaagattgat ggacttagcc ctcaaatttc agtatctata cagtactaga   4200

ccatgcattc ttaaaatatt agataccagg tagtatatat tgtttctgta caaaaatgac   4260

tgtattctct caccagtagg acttaaactt tgtttctcca gtggcttagc tcctgttcct   4320

ttgggtgatc actagcaccc atttttgaga aagctggttc tacatggggg gatagctgtg   4380

gaatagataa tttgctgcat gttaattctc aagaactaag cctgtgccag tgctttccta   4440

agcagtatac ctttaatcag aactcattcc cagaacctgg atgctattac acatgctttt   4500

aagaaacgtc aatgtatatc cttttataac tctaccactt tggggcaagc tattccagca   4560

ctggttttga atgctgtatg caaccagtct gaataccaca tacgctgcac tgttcttaga   4620

gggtttccat acttaccacc gatctacaag ggttgatccc tgtttttacc atcaatcatc   4680

accctgtggt gcaacacttg aaagacccgg ctagaggcac tatggacttc aggatccact   4740

agacagtttt cagtttgctt ggaggtagct gggtaatcaa aaatgtttag tcattgattc   4800

aatgtgaacg attacggtct ttatgaccaa gagtctgaaa atctttttgt tatgctgttt   4860

agtattcgtt tgatattgtt acttttcacc tgttgagccc aaattcagga ttggttcagt   4920

ggcagcaatg aagttgccat ttaaatttgt tcatagccta catcaccaag gtctctgtgt   4980

caaacctgtg gccactctat atgcactttg tttactcttt atacaaataa atatactaaa   5040

gactttacat gca                                                      5053


<210>  250
<211>  1154
<212>  PRT
<213>  Homosapiens

<400>  250

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys 
            340                 345                 350         


Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr 
        355                 360                 365             


Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 
    370                 375                 380                 


Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 
                405                 410                 415     


Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 
            420                 425                 430         


Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr 
        435                 440                 445             


Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 
    450                 455                 460                 


Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 
465                 470                 475                 480 


Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 
                485                 490                 495     


Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser 
            500                 505                 510         


Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys 
        515                 520                 525             


Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys 
    530                 535                 540                 


Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp 
                565                 570                 575     


Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 
            580                 585                 590         


Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 
        595                 600                 605             


Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 
    610                 615                 620                 


Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser 
625                 630                 635                 640 


Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val 
                645                 650                 655     


Cys Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly 
            660                 665                 670         


Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr 
        675                 680                 685             


Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr 
    690                 695                 700                 


Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu 
705                 710                 715                 720 


Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys 
                725                 730                 735     


Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys 
            740                 745                 750         


Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys 
        755                 760                 765             


Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp 
    770                 775                 780                 


Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile 
785                 790                 795                 800 


Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser 
                805                 810                 815     


Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro 
            820                 825                 830         


Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu 
        835                 840                 845             


Glu Glu Gln Asn Pro Asp Ile Val Ser Glu Lys Lys Pro Ala Thr Glu 
    850                 855                 860                 


Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp 
865                 870                 875                 880 


Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro 
                885                 890                 895     


Glu Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro 
            900                 905                 910         


Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile 
        915                 920                 925             


Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys 
    930                 935                 940                 


Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro 
945                 950                 955                 960 


Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn 
                965                 970                 975     


Leu Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp 
            980                 985                 990         


Tyr Leu Gly Ser Arg Gln Tyr Val  His Arg Asp Leu Ala  Ala Arg Asn 
        995                 1000                 1005             


Val Leu  Val Glu Ser Glu His  Gln Val Lys Ile Gly  Asp Phe Gly 
    1010                 1015                 1020             


Leu Thr  Lys Ala Ile Glu Thr  Asp Lys Glu Tyr Tyr  Thr Val Lys 
    1025                 1030                 1035             


Asp Asp  Arg Asp Ser Pro Val  Phe Trp Tyr Ala Pro  Glu Cys Leu 
    1040                 1045                 1050             


Met Gln  Ser Lys Phe Tyr Ile  Ala Ser Asp Val Trp  Ser Phe Gly 
    1055                 1060                 1065             


Val Thr  Leu His Glu Leu Leu  Thr Tyr Cys Asp Ser  Asp Ser Ser 
    1070                 1075                 1080             


Pro Met  Ala Leu Phe Leu Lys  Met Ile Gly Pro Thr  His Gly Gln 
    1085                 1090                 1095             


Met Thr  Val Thr Arg Leu Val  Asn Thr Leu Lys Glu  Gly Lys Arg 
    1100                 1105                 1110             


Leu Pro  Cys Pro Pro Asn Cys  Pro Asp Glu Val Tyr  Gln Leu Met 
    1115                 1120                 1125             


Arg Lys  Cys Trp Glu Phe Gln  Pro Ser Asn Arg Thr  Ser Phe Gln 
    1130                 1135                 1140             


Asn Leu  Ile Glu Gly Phe Glu  Ala Leu Leu Lys 
    1145                 1150                 


<210>  251
<211>  1191
<212>  DNA
<213>  Homosapiens

<400>  251
atggccatat tctccattgg ttgtatgatt agctcctttt ctgttggact gtttgtcaac     60

agctttgaca ggcgtaattc aatgcttact gtcaacctgt tggctgccac tggtggctgc    120

cttatgggac tgtgtaaagt agctgagttg gttgaaatac tgatcctggc ctacttggtt    180

attggcctct tctgcagact ctgcacaggt tttgtgccca cgtacatcgg agacatctca    240

cctattggcc tgcaaggtgt ctttggcact ctcaaccagc tgggcattgt tgttggaatt    300

ctggtggccc agatctttga tctggaattc atcctggggt ctgaagacct atggcctgtg    360

ctattaggct ttcccatctc tcctgctatg ctacaaagtg cagcccttcc tttttgccct    420

gaaagtccca gattcttgct cattaacaga aaagaagagg agaatgctaa ggagatcctc    480

cagtggttgt ggggcaccca ggatgtatcc caagacatcc aggagatgaa agatgagagt    540

gcaaggatgg cacaagaaaa gcaagtcact gtgctggagc tctttagagt atccagctac    600

cgacagccca tcatcatttc catcatgctc cagctctctc agcagctctc tgtaatcaat    660

actgtgttct attactcaac aggaatcttt aagggtgcag gtgttcaaga gcccatctgt    720

gtcaccattg gtgtgggtgt ggttaatact atcttcacta tagtttccct atttctagtg    780

gaaagggcag taagaaggac tctacatatg ataggccttg gagggatggc tttttgttcc    840

atcctcatgt ctgtttgttt gttattgaag gatgagtgta atgggataag ctttgtctgt    900

attggggcta tcttggtctt tgtggtcttc tttgaaattg ggccagacca cattccctgg    960

tttattgtgg ctgaactctt cagccagggc cctggcccag ctgtgatggc agtggccggc   1020

tgctccacct ggacctccaa cttcctagtc agattgcttt tcccttctgc tgcttactat   1080

ttaggagcct acgtttttat tatcttcacc gacttcctca ttaccttctt gatctttacc   1140

ttcttcaaag tccctgagat gtgttacagg actttcaagg atatcacata g            1191


<210>  252
<211>  396
<212>  PRT
<213>  Homosapiens

<400>  252

Met Ala Ile Phe Ser Ile Gly Cys Met Ile Ser Ser Phe Ser Val Gly 
1               5                   10                  15      


Leu Phe Val Asn Ser Phe Asp Arg Arg Asn Ser Met Leu Thr Val Asn 
            20                  25                  30          


Leu Leu Ala Ala Thr Gly Gly Cys Leu Met Gly Leu Cys Lys Val Ala 
        35                  40                  45              


Glu Leu Val Glu Ile Leu Ile Leu Ala Tyr Leu Val Ile Gly Leu Phe 
    50                  55                  60                  


Cys Arg Leu Cys Thr Gly Phe Val Pro Thr Tyr Ile Gly Asp Ile Ser 
65                  70                  75                  80  


Pro Ile Gly Leu Gln Gly Val Phe Gly Thr Leu Asn Gln Leu Gly Ile 
                85                  90                  95      


Val Val Gly Ile Leu Val Ala Gln Ile Phe Asp Leu Glu Phe Ile Leu 
            100                 105                 110         


Gly Ser Glu Asp Leu Trp Pro Val Leu Leu Gly Phe Pro Ile Ser Pro 
        115                 120                 125             


Ala Met Leu Gln Ser Ala Ala Leu Pro Phe Cys Pro Glu Ser Pro Arg 
    130                 135                 140                 


Phe Leu Leu Ile Asn Arg Lys Glu Glu Glu Asn Ala Lys Glu Ile Leu 
145                 150                 155                 160 


Gln Trp Leu Trp Gly Thr Gln Asp Val Ser Gln Asp Ile Gln Glu Met 
                165                 170                 175     


Lys Asp Glu Ser Ala Arg Met Ala Gln Glu Lys Gln Val Thr Val Leu 
            180                 185                 190         


Glu Leu Phe Arg Val Ser Ser Tyr Arg Gln Pro Ile Ile Ile Ser Ile 
        195                 200                 205             


Met Leu Gln Leu Ser Gln Gln Leu Ser Val Ile Asn Thr Val Phe Tyr 
    210                 215                 220                 


Tyr Ser Thr Gly Ile Phe Lys Gly Ala Gly Val Gln Glu Pro Ile Cys 
225                 230                 235                 240 


Val Thr Ile Gly Val Gly Val Val Asn Thr Ile Phe Thr Ile Val Ser 
                245                 250                 255     


Leu Phe Leu Val Glu Arg Ala Val Arg Arg Thr Leu His Met Ile Gly 
            260                 265                 270         


Leu Gly Gly Met Ala Phe Cys Ser Ile Leu Met Ser Val Cys Leu Leu 
        275                 280                 285             


Leu Lys Asp Glu Cys Asn Gly Ile Ser Phe Val Cys Ile Gly Ala Ile 
    290                 295                 300                 


Leu Val Phe Val Val Phe Phe Glu Ile Gly Pro Asp His Ile Pro Trp 
305                 310                 315                 320 


Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Gly Pro Ala Val Met 
                325                 330                 335     


Ala Val Ala Gly Cys Ser Thr Trp Thr Ser Asn Phe Leu Val Arg Leu 
            340                 345                 350         


Leu Phe Pro Ser Ala Ala Tyr Tyr Leu Gly Ala Tyr Val Phe Ile Ile 
        355                 360                 365             


Phe Thr Asp Phe Leu Ile Thr Phe Leu Ile Phe Thr Phe Phe Lys Val 
    370                 375                 380                 


Pro Glu Met Cys Tyr Arg Thr Phe Lys Asp Ile Thr 
385                 390                 395     


<210>  253
<211>  2352
<212>  DNA
<213>  Homosapiens

<400>  253
agccgccggg gaggggacga gacgcagacc acacgttgcc cacgtgcgag gaccgggcag     60

gggctcagcc cctaggccgc ccggtgcgtg gggcggcggg ggctggcttt gagtcacccc    120

cgcttgtgcc agcttccccg gctcggcgga gactggcttg gggatgcctg gccgcccggc    180

ccccttctcg gacgcggcgt ggggagcgag ctggagttaa ggatgaaggg gcggccggcg    240

agtcccagtg agagcggagg gtgccagagg tagggggccg agaaacaaag ttcccggggc    300

ttcctccggg gccgcggtcg gggctgcgcg tttgaccgcc cccctcctcg cgaaggcaat    360

ggcttccaaa ctcctgcgcg cggtcatcct cgggccgccc ggctcgggca agggcaccgt    420

gtgccagagg atcgcccaga actttggtct ccagcatctc tccagcggcc acttcttgcg    480

ggagaacatc aaggccagca ccgaagttgg tgagatggca aagcagtata tagagaaaag    540

tcttttggtt ccagaccatg tgatcacacg cctaatgatg tccgagttgg agaacaggcg    600

tggccagcac tggctccttg atggttttcc taggacatta ggacaagccg aagccctgga    660

caaaatctgt gaagtggatc tagtgatcag tttgaatatt ccatttgaaa cacttaaaga    720

tcgtctcagc cgccgttgga ttcaccctcc tagcggaagg gtatataacc tggacttcaa    780

tccacctcat gtacatggta ttgatgacgt cactggtgaa ccgttagtcc agcaggagga    840

tgataaaccc gaagcagttg ctgccaggct aagacagtac aaagacgtgg caaagccagt    900

cattgaatta tacaagagcc gaggagtgct ccaccaattt tccggaacgg agacgaacaa    960

aatctggccc tacgtttaca cacttttctc aaacaagatc acacctattc agtccaaaga   1020

agcatattga ccctgcccaa tggaagaacc aggaagatgt ggtcattcat tcaatagtgt   1080

gtgtagtatt ggtgctgtgt ccaaattaga agctagctga ggtagcttgc agcatctttt   1140

ctagttgaaa tggtgaactg ataggaaaac aaatgagtag aaagagttca tgaagaggcc   1200

ctcctctgcc tttcaaaagg ctggtcacct acacatgttt aaggtgtctc tgcacatgtc   1260

tcaagcccat cacaagaaag caagtacagt gtggatttca aatggtgtgt aacttcagct   1320

ccagctggtt tttgacagct gttgctgtgg taatattttt gacatgtgat ggtgatagtc   1380

tctggttctc cccatcccca caaaggctgt tgaaccacag caccaggaag cctgagaatg   1440

aatcctgagg gctctagccc aggctttgtc ccaggctttc tggtgtgtgc cctcctggta   1500

acagtgaaat tgaagctact tactcatagt ggttgtttct ctggtcttga gtgactgtgt   1560

ccacagttca tttttttccg gtaggaataa ctccttttct acatccacgc tccatagagt   1620

ctctcctttt cagacatcct gggatgaaag aatttggctt ttttttttct tttttttttt   1680

ggacatctgt tttcactctt aggcttttaa acaatagtta ttgcttttat ccctctcaga   1740

ttctaataac tgagagcgat ggggctatat tgaatctctg tatgcactga gaactgagct   1800

atgaagagga tcttattaaa ctgctggtct gactttatgg attgacactg ttcctttctt   1860

ttattgtgaa aaaaaaaaaa aaccctgaaa gtcttgggaa ccccctaaag tcttttggga   1920

atcctcaaaa agcatgggaa gttaagtatt tagctacata aatgttgtaa gatcatatct   1980

tatgtataga agtaataaga ccatttggaa ttactggact aattgaatag ttaaggtttc   2040

tattcgggac aataaaatgt attttgaaag tgctgctaac tattgatgct gacagtgttt   2100

cactcctatg agtgacccaa acatattata aatatgtggt aaagggaatg gagcctgtgg   2160

ggttgagcag aatgttgtac tagctgtgcc tggactgagt ataacagctt tatgattatg   2220

agaaaacaaa ttctttattt tttttttctg ttccaaagat tcatcctatg gggtggccat   2280

aaagtctaga attagatact aatattttgt cattcattat aacatatcaa taaaccattt   2340

gttaaaaaaa aa                                                       2352


<210>  254
<211>  223
<212>  PRT
<213>  Homosapiens

<400>  254

Met Ala Ser Lys Leu Leu Arg Ala Val Ile Leu Gly Pro Pro Gly Ser 
1               5                   10                  15      


Gly Lys Gly Thr Val Cys Gln Arg Ile Ala Gln Asn Phe Gly Leu Gln 
            20                  25                  30          


His Leu Ser Ser Gly His Phe Leu Arg Glu Asn Ile Lys Ala Ser Thr 
        35                  40                  45              


Glu Val Gly Glu Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val 
    50                  55                  60                  


Pro Asp His Val Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg 
65                  70                  75                  80  


Arg Gly Gln His Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln 
                85                  90                  95      


Ala Glu Ala Leu Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu 
            100                 105                 110         


Asn Ile Pro Phe Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile 
        115                 120                 125             


His Pro Pro Ser Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His 
    130                 135                 140                 


Val His Gly Ile Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu 
145                 150                 155                 160 


Asp Asp Lys Pro Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp 
                165                 170                 175     


Val Ala Lys Pro Val Ile Glu Leu Tyr Lys Ser Arg Gly Val Leu His 
            180                 185                 190         


Gln Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr Thr 
        195                 200                 205             


Leu Phe Ser Asn Lys Ile Thr Pro Ile Gln Ser Lys Glu Ala Tyr 
    210                 215                 220             


<210>  255
<211>  2199
<212>  DNA
<213>  Homosapiens

<400>  255
agtccgcctg ctactcggtc ccggcgctgg gctgagggga ggggttgtct taaaagtctc     60

tccttccccc tgtaggggcg gccggcgagt cccagtgaga gcggagggtg ccagaggtag    120

ggggccgaga aacaaagttc ccggggcttc ctccggggcc gcggtcgggg ctgcgcgttt    180

gaccgccccc ctcctcgcga aggcaatggc ttccaaactc ctgcgcgcgg tcatcctcgg    240

gccgcccggc tcgggcaagg gcaccgtgtg ccagaggatc gcccagaact ttggtctcca    300

gcatctctcc agcggccact tcttgcggga gaacatcaag gccagcaccg aagttggtga    360

gatggcaaag cagtatatag agaaaagtct tttggttcca gaccatgtga tcacacgcct    420

aatgatgtcc gagttggaga acaggcgtgg ccagcactgg ctccttgatg gttttcctag    480

gacattagga caagccgaag ccctggacaa aatctgtgaa gtggatctag tgatcagttt    540

gaatattcca tttgaaacac ttaaagatcg tctcagccgc cgttggattc accctcctag    600

cggaagggta tataacctgg acttcaatcc acctcatgta catggtattg atgacgtcac    660

tggtgaaccg ttagtccagc aggaggatga taaacccgaa gcagttgctg ccaggctaag    720

acagtacaaa gacgtggcaa agccagtcat tgaattatac aagagccgag gagtgctcca    780

ccaattttcc ggaacggaga cgaacaaaat ctggccctac gtttacacac ttttctcaaa    840

caagatcaca cctattcagt ccaaagaagc atattgaccc tgcccaatgg aagaaccagg    900

aagatgtggt cattcattca atagtgtgtg tagtattggt gctgtgtcca aattagaagc    960

tagctgaggt agcttgcagc atcttttcta gttgaaatgg tgaactgata ggaaaacaaa   1020

tgagtagaaa gagttcatga agaggccctc ctctgccttt caaaaggctg gtcacctaca   1080

catgtttaag gtgtctctgc acatgtctca agcccatcac aagaaagcaa gtacagtgtg   1140

gatttcaaat ggtgtgtaac ttcagctcca gctggttttt gacagctgtt gctgtggtaa   1200

tatttttgac atgtgatggt gatagtctct ggttctcccc atccccacaa aggctgttga   1260

accacagcac caggaagcct gagaatgaat cctgagggct ctagcccagg ctttgtccca   1320

ggctttctgg tgtgtgccct cctggtaaca gtgaaattga agctacttac tcatagtggt   1380

tgtttctctg gtcttgagtg actgtgtcca cagttcattt ttttccggta ggaataactc   1440

cttttctaca tccacgctcc atagagtctc tccttttcag acatcctggg atgaaagaat   1500

ttggcttttt tttttctttt tttttttgga catctgtttt cactcttagg cttttaaaca   1560

atagttattg cttttatccc tctcagattc taataactga gagcgatggg gctatattga   1620

atctctgtat gcactgagaa ctgagctatg aagaggatct tattaaactg ctggtctgac   1680

tttatggatt gacactgttc ctttctttta ttgtgaaaaa aaaaaaaaac cctgaaagtc   1740

ttgggaaccc cctaaagtct tttgggaatc ctcaaaaagc atgggaagtt aagtatttag   1800

ctacataaat gttgtaagat catatcttat gtatagaagt aataagacca tttggaatta   1860

ctggactaat tgaatagtta aggtttctat tcgggacaat aaaatgtatt ttgaaagtgc   1920

tgctaactat tgatgctgac agtgtttcac tcctatgagt gacccaaaca tattataaat   1980

atgtggtaaa gggaatggag cctgtggggt tgagcagaat gttgtactag ctgtgcctgg   2040

actgagtata acagctttat gattatgaga aaacaaattc tttatttttt ttttctgttc   2100

caaagattca tcctatgggg tggccataaa gtctagaatt agatactaat attttgtcat   2160

tcattataac atatcaataa accatttgtt aaaaaaaaa                          2199


<210>  256
<211>  223
<212>  PRT
<213>  Homosapiens

<400>  256

Met Ala Ser Lys Leu Leu Arg Ala Val Ile Leu Gly Pro Pro Gly Ser 
1               5                   10                  15      


Gly Lys Gly Thr Val Cys Gln Arg Ile Ala Gln Asn Phe Gly Leu Gln 
            20                  25                  30          


His Leu Ser Ser Gly His Phe Leu Arg Glu Asn Ile Lys Ala Ser Thr 
        35                  40                  45              


Glu Val Gly Glu Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val 
    50                  55                  60                  


Pro Asp His Val Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg 
65                  70                  75                  80  


Arg Gly Gln His Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln 
                85                  90                  95      


Ala Glu Ala Leu Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu 
            100                 105                 110         


Asn Ile Pro Phe Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile 
        115                 120                 125             


His Pro Pro Ser Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His 
    130                 135                 140                 


Val His Gly Ile Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu 
145                 150                 155                 160 


Asp Asp Lys Pro Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp 
                165                 170                 175     


Val Ala Lys Pro Val Ile Glu Leu Tyr Lys Ser Arg Gly Val Leu His 
            180                 185                 190         


Gln Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr Thr 
        195                 200                 205             


Leu Phe Ser Asn Lys Ile Thr Pro Ile Gln Ser Lys Glu Ala Tyr 
    210                 215                 220             


<210>  257
<211>  2241
<212>  DNA
<213>  Homosapiens

<400>  257
ttacgtaagg cgcgagtccc gcgcggccgg ccggggctcc gcgactgggc gggcggaggc     60

ggcgccgccc tgcaggatcc gggctggaag cctctcggag tgctgcctcc agccaagggg    120

cggccggcga gtcccagtga gagcggaggg tgccagaggt agggggccga gaaacaaagt    180

tcccggggct tcctccgggg ccgcggtcgg ggctgcgcgt ttgaccgccc ccctcctcgc    240

gaaggcaatg gcttccaaac tcctgcgcgc ggtcatcctc gggccgcccg gctcgggcaa    300

gggcaccgtg tgccagagga tcgcccagaa ctttggtctc cagcatctct ccagcggcca    360

cttcttgcgg gagaacatca aggccagcac cgaagttggt gagatggcaa agcagtatat    420

agagaaaagt cttttggttc cagaccatgt gatcacacgc ctaatgatgt ccgagttgga    480

gaacaggcgt ggccagcact ggctccttga tggttttcct aggacattag gacaagccga    540

agccctggac aaaatctgtg aagtggatct agtgatcagt ttgaatattc catttgaaac    600

acttaaagat cgtctcagcc gccgttggat tcaccctcct agcggaaggg tatataacct    660

ggacttcaat ccacctcatg tacatggtat tgatgacgtc actggtgaac cgttagtcca    720

gcaggaggat gataaacccg aagcagttgc tgccaggcta agacagtaca aagacgtggc    780

aaagccagtc attgaattat acaagagccg aggagtgctc caccaatttt ccggaacgga    840

gacgaacaaa atctggccct acgtttacac acttttctca aacaagatca cacctattca    900

gtccaaagaa gcatattgac cctgcccaat ggaagaacca ggaagatgtg gtcattcatt    960

caatagtgtg tgtagtattg gtgctgtgtc caaattagaa gctagctgag gtagcttgca   1020

gcatcttttc tagttgaaat ggtgaactga taggaaaaca aatgagtaga aagagttcat   1080

gaagaggccc tcctctgcct ttcaaaaggc tggtcaccta cacatgttta aggtgtctct   1140

gcacatgtct caagcccatc acaagaaagc aagtacagtg tggatttcaa atggtgtgta   1200

acttcagctc cagctggttt ttgacagctg ttgctgtggt aatatttttg acatgtgatg   1260

gtgatagtct ctggttctcc ccatccccac aaaggctgtt gaaccacagc accaggaagc   1320

ctgagaatga atcctgaggg ctctagccca ggctttgtcc caggctttct ggtgtgtgcc   1380

ctcctggtaa cagtgaaatt gaagctactt actcatagtg gttgtttctc tggtcttgag   1440

tgactgtgtc cacagttcat ttttttccgg taggaataac tccttttcta catccacgct   1500

ccatagagtc tctccttttc agacatcctg ggatgaaaga atttggcttt tttttttctt   1560

tttttttttg gacatctgtt ttcactctta ggcttttaaa caatagttat tgcttttatc   1620

cctctcagat tctaataact gagagcgatg gggctatatt gaatctctgt atgcactgag   1680

aactgagcta tgaagaggat cttattaaac tgctggtctg actttatgga ttgacactgt   1740

tcctttcttt tattgtgaaa aaaaaaaaaa accctgaaag tcttgggaac cccctaaagt   1800

cttttgggaa tcctcaaaaa gcatgggaag ttaagtattt agctacataa atgttgtaag   1860

atcatatctt atgtatagaa gtaataagac catttggaat tactggacta attgaatagt   1920

taaggtttct attcgggaca ataaaatgta ttttgaaagt gctgctaact attgatgctg   1980

acagtgtttc actcctatga gtgacccaaa catattataa atatgtggta aagggaatgg   2040

agcctgtggg gttgagcaga atgttgtact agctgtgcct ggactgagta taacagcttt   2100

atgattatga gaaaacaaat tctttatttt ttttttctgt tccaaagatt catcctatgg   2160

ggtggccata aagtctagaa ttagatacta atattttgtc attcattata acatatcaat   2220

aaaccatttg ttaaaaaaaa a                                             2241


<210>  258
<211>  223
<212>  PRT
<213>  Homosapiens

<400>  258

Met Ala Ser Lys Leu Leu Arg Ala Val Ile Leu Gly Pro Pro Gly Ser 
1               5                   10                  15      


Gly Lys Gly Thr Val Cys Gln Arg Ile Ala Gln Asn Phe Gly Leu Gln 
            20                  25                  30          


His Leu Ser Ser Gly His Phe Leu Arg Glu Asn Ile Lys Ala Ser Thr 
        35                  40                  45              


Glu Val Gly Glu Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val 
    50                  55                  60                  


Pro Asp His Val Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg 
65                  70                  75                  80  


Arg Gly Gln His Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln 
                85                  90                  95      


Ala Glu Ala Leu Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu 
            100                 105                 110         


Asn Ile Pro Phe Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile 
        115                 120                 125             


His Pro Pro Ser Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His 
    130                 135                 140                 


Val His Gly Ile Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu 
145                 150                 155                 160 


Asp Asp Lys Pro Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp 
                165                 170                 175     


Val Ala Lys Pro Val Ile Glu Leu Tyr Lys Ser Arg Gly Val Leu His 
            180                 185                 190         


Gln Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr Thr 
        195                 200                 205             


Leu Phe Ser Asn Lys Ile Thr Pro Ile Gln Ser Lys Glu Ala Tyr 
    210                 215                 220             


<210>  259
<211>  5750
<212>  DNA
<213>  Homosapiens

<400>  259
ataaccccgc acaccgactt gcatgcaatt atcatagccc gagtgctcct ccgttgagag     60

acttcgcccc cgagaccgct gactgtgaat gacaaatcaa aagtcagggt tgcagaatca    120

gccggacttt cctgctcatt tgcagcagag ggaggaagca gagaatgaaa gattctgaaa    180

ataaaggtgc ctcatctcca gacatggagc ccagctatgg gggaggtctc tttgacatgg    240

taaaaggagg tgcagggagg ctctttagta acctaaagga caacttgaaa gacaccctca    300

aagacacatc ttctagagtg atacaatctg tgaccagcta cacaaaggga gatttagact    360

tcacttatgt tacctccaga attattgtga tgtcctttcc tctggacaat gttgacatag    420

gattcaggaa tcaggttgat gacattcgaa gctttttgga ttccagacat cttgaccact    480

acacagtata caatctgtca cctaagtctt atcgaactgc caagtttcac agccgggtct    540

cagaatgcag ttggcccatt aggcaggctc ccagtctgca caaccttttt gctgtgtgtc    600

ggaatatgta taactggcta ctgcagaatc ccaaaaatgt ctgtgttgtc cactgcttgg    660

atggacgggc ggcatcatca attctggttg gtgctatgtt cattttctgt aatctctact    720

ctactcctgg cccagccatt cgattgctat atgcaaagcg accaggaatt ggactttcac    780

catcccatag gagatacctg ggctatatgt gtgacctact ggcagacaag ccctaccgcc    840

ctcacttcaa gcctctcaca attaagtcga tcactgtcag tccaataccc tttttcaaca    900

aacagaggaa tggatgtcgc ccttactgtg atgtactcat tggagaaacc aaaatatatt    960

cgacttgcac agattttgaa cgaatgaaag aatatcgtgt ccaagatgga aaaatcttca   1020

ttcccttgaa catcactgtg caaggagacg tggttgtttc catgtatcac ttgaggtcaa   1080

ccattgggag ccggctacag gctaaggtga ccaacacaca gatattccag cttcagtttc   1140

acactggatt cataccactg gacacaacag ttttaaagtt caccaagcct gagttagatg   1200

catgtgatgt accagaaaaa tatcctcagc tatttcaggt gacactggat gtagaactac   1260

agccccatga caaagtaata gacttaactc caccatggga acattactgc acaaaagatg   1320

tcaatcccag catcctcttc tcttctcacc aggaacatca agatacgctg gccttaggag   1380

gacaggctcc aatagatatc cctccagaca accccaggca ttacggacaa agtggtttct   1440

ttgcctctct ctgttggcaa gatcagaaat cggagaagtc attctgtgag gaggaccacg   1500

ctgccctagt gaatcaggaa agtgagcaat cagatgatga acttctgaca ctttccagtc   1560

cgcatggcaa tgccaatggt gacaagcctc atggagtcaa gaagcccagc aaaaagcagc   1620

aggagccagc agcccctcca ccccctgagg atgtggacct tttgggcctg gaagggtctg   1680

caatgagtaa cagcttctct ccgccagcgg ctcctcccac caattctgaa ctactgagtg   1740

acctgtttgg gggtggaggt gcagctggtc ccacccaggc tggacagtca ggagtggaag   1800

atgtgtttca tcctagtgga cctgcgtcta cccagtcaac accacgccgc tctgccacct   1860

ccacctctgc gtctccaacc ctaagagtgg gagaaggtgc cacctttgac ccatttggag   1920

caccttctaa accatcaggt caggatttgc tgggttcttt tctgaacaca tccagtgctt   1980

ccagtgaccc ctttctccag ccaacaagaa gtccttcgcc cacagtacat gcttctagta   2040

cgcctgctgt gaacattcag ccagatgttt ctggaggttg ggactggcat gctaaaccag   2100

gaggctttgg aatgggaagc aagtcagctg ccaccagccc aaccggatcc tcgcatggta   2160

ctcccaccca tcaaagcaaa ccccagactc tggatccttt tgccgacctt gggacactag   2220

gtagttcttc ctttgccagc aaacccacca caccaactgg attgggtgga ggattcccgc   2280

ctctcagctc gccacagaag gcgtctcccc agcctatggg tggcgggtgg cagcagggag   2340

gtgcctacaa ctggcagcag ccacagccta agcctcagcc cagcatgccc cactcctctc   2400

cccagaaccg acccaactac aacgtgagct tctcagccat gcctgggggc cagaacgaac   2460

gtgggaaagg atcaagtaat ttggaaggga aacaaaaagc agctgatttt gaagacctac   2520

tctctggtca aggtttcaat gctcacaaag acaaaaaggg gcctcggaca atagctgaga   2580

tgagaaagga ggaaatggcc aaggaaatgg atcctgagaa attaaagatt ctggaatgga   2640

ttgaaggcaa agaaagaaat atcagagccc ttctttccac gatgcatacc gtactatggg   2700

ctggggagac caagtggaaa ccagttggca tggcagacct ggtaacacca gagcaggtga   2760

agaaggtgta caggaaggct gtcctggtgg tgcacccaga taaagctact gggcaaccct   2820

atgaacaata cgcaaagatg attttcatgg agctcaatga tgcctggtct gaatttgaaa   2880

accaaggcca aaagccctta tattaattta tgagcttttc catctctgct gcagacctgt   2940

gctaatgctt agtgtgtgtc acaattctga ggttttcgca gatgaaccaa aaactccagt   3000

aacatgtttt cagtactaaa ccgttaagtt actcatgaat taatttctca ttgataagga   3060

atgtggatgt ttggtttctc caaagttccc accataaaag atccaaagca tgagaggaac   3120

ttctagtcag atgaccttgc agaaccaccg cattccaccc tgccctttgg ggagcctact   3180

cagcattcta cctggggaaa tggaaaacag aggccaccac ccatgaaggc ataacaccca   3240

tcacattgtc tgagaatagg attaatgagc aaaagttatg ataatagagt tatatgatgg   3300

tttaatggtt tctagatttt tcttggaaag atataatttg agcagtggct ttatgcagac   3360

tccaagaaca aaaccaccag gtattttttt ttaagtaaaa atttactaag gcctttagca   3420

taatactgta aatgtctttt ggtcaagaga actaacaaat ataaaggaac ttgaaatgtg   3480

gggagtgata atagtccagt gattaaacta cagtccagtg attaccacca actttctgac   3540

taagctaaaa atgaatgaaa atggtggcta aagaaaatag ggactctgaa gatgtcgaaa   3600

tctttattcc tggttaggaa ggtgggccgc tacccttctt tccctttaga aaactgtgat   3660

taattaaata aaaagtctta ctactataac aactctaaac ctggtttaaa tgaaacatct   3720

aattttgctg taaggcttaa tgctcttctt ttgtttagcc aagaaaacat tcttagttgg   3780

aaacaggtgg taaagtagtt tggcctgttc acaacttatc aggaccaata tctagtgtgg   3840

actcagtgtt ctctaggttt gtgagcagtt gtggtaagag aatggaaggc aacactgaat   3900

aggagttaag ggaatggcac gatcacagtg agagagctgc actcacctgc agacccagtc   3960

agatggcttg tcagtatctg ctctgaggaa ccaggtccca cctccccaca aggcaaatct   4020

agacccatta aattattaca gtgggctttt ttgttttaaa agtggttggg gatccacagg   4080

aacgacattc atacagggac atttgtgaaa gcaaagcaag aatgaatgct ttcccgatct   4140

cagactggct ggattcagat cagtgtgttg gctggttctc attttaaggg gtaagcagtt   4200

tgctattctg tgactttagt agatctcttt tgtgtgcaca tatacaatgt gcattataca   4260

tatatattaa atatatccac aaagcagatg ggcaaaaaga ttttcatgct aatcttcaaa   4320

ggttcatgct caatattgtg aaaagctttt aaaagttgtt ttgaaaagac aatcattttt   4380

tgtttttgtt ttaactttct tgtggcaagc tataccggaa aagcggcatg tcaaaaatac   4440

tttaggttct acatagatct ctttctctct tttgttttgt ttgtttgttt gttaaagttc   4500

attatttatt ttacctttta ctgacaatgt gaaactcgaa gaaaatgttc tctttttaaa   4560

tatacagtca taaactgttc aaggtaacca taacaaacta ggtgttattt attaacgtat   4620

tataaaataa tgtttgatcc agtatgtgct tgtcttattt aaaattggaa tgtgagacat   4680

gttgctgtga cctgtttttc tttctcattc acatttgtag atattgtgtg aactacagta   4740

tataatgata acaattaaaa ggatattctg tggatgtcac gtattttgaa atgatagaac   4800

tacattagct ttgtatcatg tttggataat tcatcaatgt tcacagttta aaacatcatt   4860

aaacattatg taattacaat gagaaagaat cttacttaaa tttggagatt ttcccccaca   4920

tctcttttcc ggatacatta taattctgga cccctattta tctcaaaact cttaatatat   4980

gcagaccaac aggtctttgc attcctttta aataactggt tgtgacaaag cttgttgttg   5040

atcagattca ctgtttcatc atatttattg taatatattt tttgttttgt aaatatgtta   5100

caacaaaatg tgattggtct aaaatatttg taatgtatat taaaaggttc aaaaatattt   5160

gtataaatct aagttatttg ggtacttgta ggaatacaat gaggagcttg aatgccacct   5220

tctgacatga tttactttta aggaaagtta tgaggagaga atacaaaaag catgcaccaa   5280

aatgtaatct gacaggattt ctggatttat acgtaatcac tcctgcccca acacacacac   5340

acacacacac acacacacac acacacatgc acgcacacat gattttgatt atgctacatg   5400

atatatgttt caaaaagaat tagcatagaa atcctggtct cctagccaaa aaaatcaaag   5460

gattttcaaa aaaacgaatc tgtatgttga ggcaaaagga ttgaacctgg aagtctggga   5520

ctttatcata gaaacaaagt ctcagatatt ttagttcttt ggaaacaaat gctgtaattc   5580

aaaagcattt gacctgtcac tgtactatct acatgtggaa gaatgttcaa gttgaatcct   5640

aatgccgtga atgaaacaca gtctgtgtag ggaatgagca aaaaagttga attccaattg   5700

ctttttggcc ttttggctaa aataaatgta gcatctaatt ttatcagttt              5750


<210>  260
<211>  913
<212>  PRT
<213>  Homosapiens

<400>  260

Met Lys Asp Ser Glu Asn Lys Gly Ala Ser Ser Pro Asp Met Glu Pro 
1               5                   10                  15      


Ser Tyr Gly Gly Gly Leu Phe Asp Met Val Lys Gly Gly Ala Gly Arg 
            20                  25                  30          


Leu Phe Ser Asn Leu Lys Asp Asn Leu Lys Asp Thr Leu Lys Asp Thr 
        35                  40                  45              


Ser Ser Arg Val Ile Gln Ser Val Thr Ser Tyr Thr Lys Gly Asp Leu 
    50                  55                  60                  


Asp Phe Thr Tyr Val Thr Ser Arg Ile Ile Val Met Ser Phe Pro Leu 
65                  70                  75                  80  


Asp Asn Val Asp Ile Gly Phe Arg Asn Gln Val Asp Asp Ile Arg Ser 
                85                  90                  95      


Phe Leu Asp Ser Arg His Leu Asp His Tyr Thr Val Tyr Asn Leu Ser 
            100                 105                 110         


Pro Lys Ser Tyr Arg Thr Ala Lys Phe His Ser Arg Val Ser Glu Cys 
        115                 120                 125             


Ser Trp Pro Ile Arg Gln Ala Pro Ser Leu His Asn Leu Phe Ala Val 
    130                 135                 140                 


Cys Arg Asn Met Tyr Asn Trp Leu Leu Gln Asn Pro Lys Asn Val Cys 
145                 150                 155                 160 


Val Val His Cys Leu Asp Gly Arg Ala Ala Ser Ser Ile Leu Val Gly 
                165                 170                 175     


Ala Met Phe Ile Phe Cys Asn Leu Tyr Ser Thr Pro Gly Pro Ala Ile 
            180                 185                 190         


Arg Leu Leu Tyr Ala Lys Arg Pro Gly Ile Gly Leu Ser Pro Ser His 
        195                 200                 205             


Arg Arg Tyr Leu Gly Tyr Met Cys Asp Leu Leu Ala Asp Lys Pro Tyr 
    210                 215                 220                 


Arg Pro His Phe Lys Pro Leu Thr Ile Lys Ser Ile Thr Val Ser Pro 
225                 230                 235                 240 


Ile Pro Phe Phe Asn Lys Gln Arg Asn Gly Cys Arg Pro Tyr Cys Asp 
                245                 250                 255     


Val Leu Ile Gly Glu Thr Lys Ile Tyr Ser Thr Cys Thr Asp Phe Glu 
            260                 265                 270         


Arg Met Lys Glu Tyr Arg Val Gln Asp Gly Lys Ile Phe Ile Pro Leu 
        275                 280                 285             


Asn Ile Thr Val Gln Gly Asp Val Val Val Ser Met Tyr His Leu Arg 
    290                 295                 300                 


Ser Thr Ile Gly Ser Arg Leu Gln Ala Lys Val Thr Asn Thr Gln Ile 
305                 310                 315                 320 


Phe Gln Leu Gln Phe His Thr Gly Phe Ile Pro Leu Asp Thr Thr Val 
                325                 330                 335     


Leu Lys Phe Thr Lys Pro Glu Leu Asp Ala Cys Asp Val Pro Glu Lys 
            340                 345                 350         


Tyr Pro Gln Leu Phe Gln Val Thr Leu Asp Val Glu Leu Gln Pro His 
        355                 360                 365             


Asp Lys Val Ile Asp Leu Thr Pro Pro Trp Glu His Tyr Cys Thr Lys 
    370                 375                 380                 


Asp Val Asn Pro Ser Ile Leu Phe Ser Ser His Gln Glu His Gln Asp 
385                 390                 395                 400 


Thr Leu Ala Leu Gly Gly Gln Ala Pro Ile Asp Ile Pro Pro Asp Asn 
                405                 410                 415     


Pro Arg His Tyr Gly Gln Ser Gly Phe Phe Ala Ser Leu Cys Trp Gln 
            420                 425                 430         


Asp Gln Lys Ser Glu Lys Ser Phe Cys Glu Glu Asp His Ala Ala Leu 
        435                 440                 445             


Val Asn Gln Glu Ser Glu Gln Ser Asp Asp Glu Leu Leu Thr Leu Ser 
    450                 455                 460                 


Ser Pro His Gly Asn Ala Asn Gly Asp Lys Pro His Gly Val Lys Lys 
465                 470                 475                 480 


Pro Ser Lys Lys Gln Gln Glu Pro Ala Ala Pro Pro Pro Pro Glu Asp 
                485                 490                 495     


Val Asp Leu Leu Gly Leu Glu Gly Ser Ala Met Ser Asn Ser Phe Ser 
            500                 505                 510         


Pro Pro Ala Ala Pro Pro Thr Asn Ser Glu Leu Leu Ser Asp Leu Phe 
        515                 520                 525             


Gly Gly Gly Gly Ala Ala Gly Pro Thr Gln Ala Gly Gln Ser Gly Val 
    530                 535                 540                 


Glu Asp Val Phe His Pro Ser Gly Pro Ala Ser Thr Gln Ser Thr Pro 
545                 550                 555                 560 


Arg Arg Ser Ala Thr Ser Thr Ser Ala Ser Pro Thr Leu Arg Val Gly 
                565                 570                 575     


Glu Gly Ala Thr Phe Asp Pro Phe Gly Ala Pro Ser Lys Pro Ser Gly 
            580                 585                 590         


Gln Asp Leu Leu Gly Ser Phe Leu Asn Thr Ser Ser Ala Ser Ser Asp 
        595                 600                 605             


Pro Phe Leu Gln Pro Thr Arg Ser Pro Ser Pro Thr Val His Ala Ser 
    610                 615                 620                 


Ser Thr Pro Ala Val Asn Ile Gln Pro Asp Val Ser Gly Gly Trp Asp 
625                 630                 635                 640 


Trp His Ala Lys Pro Gly Gly Phe Gly Met Gly Ser Lys Ser Ala Ala 
                645                 650                 655     


Thr Ser Pro Thr Gly Ser Ser His Gly Thr Pro Thr His Gln Ser Lys 
            660                 665                 670         


Pro Gln Thr Leu Asp Pro Phe Ala Asp Leu Gly Thr Leu Gly Ser Ser 
        675                 680                 685             


Ser Phe Ala Ser Lys Pro Thr Thr Pro Thr Gly Leu Gly Gly Gly Phe 
    690                 695                 700                 


Pro Pro Leu Ser Ser Pro Gln Lys Ala Ser Pro Gln Pro Met Gly Gly 
705                 710                 715                 720 


Gly Trp Gln Gln Gly Gly Ala Tyr Asn Trp Gln Gln Pro Gln Pro Lys 
                725                 730                 735     


Pro Gln Pro Ser Met Pro His Ser Ser Pro Gln Asn Arg Pro Asn Tyr 
            740                 745                 750         


Asn Val Ser Phe Ser Ala Met Pro Gly Gly Gln Asn Glu Arg Gly Lys 
        755                 760                 765             


Gly Ser Ser Asn Leu Glu Gly Lys Gln Lys Ala Ala Asp Phe Glu Asp 
    770                 775                 780                 


Leu Leu Ser Gly Gln Gly Phe Asn Ala His Lys Asp Lys Lys Gly Pro 
785                 790                 795                 800 


Arg Thr Ile Ala Glu Met Arg Lys Glu Glu Met Ala Lys Glu Met Asp 
                805                 810                 815     


Pro Glu Lys Leu Lys Ile Leu Glu Trp Ile Glu Gly Lys Glu Arg Asn 
            820                 825                 830         


Ile Arg Ala Leu Leu Ser Thr Met His Thr Val Leu Trp Ala Gly Glu 
        835                 840                 845             


Thr Lys Trp Lys Pro Val Gly Met Ala Asp Leu Val Thr Pro Glu Gln 
    850                 855                 860                 


Val Lys Lys Val Tyr Arg Lys Ala Val Leu Val Val His Pro Asp Lys 
865                 870                 875                 880 


Ala Thr Gly Gln Pro Tyr Glu Gln Tyr Ala Lys Met Ile Phe Met Glu 
                885                 890                 895     


Leu Asn Asp Ala Trp Ser Glu Phe Glu Asn Gln Gly Gln Lys Pro Leu 
            900                 905                 910         


Tyr 
    


<210>  261
<211>  2250
<212>  DNA
<213>  Homosapiens

<400>  261
gagacgctgt ctgcttgctg ccttaagaca gctagctgaa ttgctgatta acttttaaaa     60

tacccagctt ggtttatttt tcttagaatc tgttgctaag actggggacg ctgttttctt    120

ttacaaaggg aaatctaagt taatttcaag gcattcgaaa tggggaaaga ctattattgc    180

attttgggaa ttgagaaagg agcttcagat gaagatatta aaaaggctta ccgaaaacaa    240

gccctcaaat ttcatccgga caagaacaaa tctcctcagg cagaggaaaa atttaaagag    300

gtcgcagaag cttatgaagt attgagtgat cctaaaaaga gagaaatata tgatcagttt    360

ggggaggaag ggttgaaagg aggagcagga ggtactgatg gacaaggagg taccttccgg    420

tacacctttc atggcgatcc tcatgctaca tttgctgcat ttttcggagg gtccaacccc    480

tttgaaattt tctttggaag acgaatgggt ggtggtagag attctgaaga aatggaaata    540

gatggtgatc cttttagtgc ctttggtttc agcatgaatg gatatccaag agacaggaat    600

tctgtggggc catcccgcct caaacaagat cctccagtta ttcatgaact tagagtatca    660

cttgaagaga tatatagtgg ttgtaccaaa cggatgaaga tttctcgaaa aaggctaaac    720

gctgatggaa ggagttacag atctgaggac aaaattctta ccattgagat taaaaaaggg    780

tggaaagaag gcaccaaaat tacttttcca agagaaggag atgaaacacc aaatagtatt    840

ccagcagaca ttgtttttat cattaaagac aaagatcatc caaaatttaa aagggatgga    900

tcaaatataa tttatactgc taaaattagt ttacgagagg cattgtgtgg ctgctcaatt    960

aatgtaccaa cactggatgg aagaaacata cctatgtcag taaatgatat tgtgaaaccc   1020

ggaatgagga gaagaattat tggatatggg ctgccatttc caaaaaatcc tgaccaacgt   1080

ggtgaccttc taatagaatt tgaggtgtcc ttcccagata ctatatcttc ttcatccaaa   1140

gaagtactta ggaaacatct tcctgcctca tagaatgaag aactttgtta cacatatttt   1200

gataaggcac tgaaaatata aaaggactgg tagtttactg atgtagatgt gaattctgta   1260

taaagatgtg taaattcttt tgagggttca ttaaattgca tgaatagaga cgggtcaaat   1320

aaataggcaa aagggatttt tacagttaga gataaaagag aaaaccattc actgtatttt   1380

atttcatttc tcctgattca gatattttta gtaatttgct tatatgtaaa agttgttttt   1440

gtggagtcag tggatatatt tctaatgaag tgctagacta tccaattact taatttctta   1500

tacctttaga taatcagtat gaaaagttcc catttataat ggaaatgaaa attcttaact   1560

aaactataca tgtaatatgt atttctagaa gagaataaaa acccaagtca gttattagat   1620

ttaaatcacc ttctgaaatg ctgctatagg gctggtatct gtaaaagaat atcctgatgc   1680

atctgtttca ccattttgat ttttaaagta tgctgtagca tttcttaata acatcgttgt   1740

gatgttctta aggcagatct ttcttcataa aaaggaaagt aatggcaatt tctctcctgt   1800

ggaaatccca attgcttgaa ttactgatat tttagaatag actttttaaa atgccatatg   1860

taattttatg caagttgact atatatcttg tacttaataa attataggct cattttgttc   1920

tctgctagtt taaagtaatt cgtttaataa tagatgtgtt tttagaggaa atgctgttac   1980

ttggaattaa ttttccagtt atacagtctt ctataactta ctaataatat tctatatgta   2040

ctttatgtaa tttccctaaa aagaatgaac taccactaca ctatggtgtt aaaccaaaat   2100

atagggaaaa taaacactaa ctgctgctta tggataatgt tgcaactact tgttatgcat   2160

ataaatattt tactttttca catgtataga ttgcatttct taggtgtttt aattttttaa   2220

atatatttat gttttaaaaa aaaaaaaaaa                                    2250


<210>  262
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  262

Met Gly Lys Asp Tyr Tyr Cys Ile Leu Gly Ile Glu Lys Gly Ala Ser 
1               5                   10                  15      


Asp Glu Asp Ile Lys Lys Ala Tyr Arg Lys Gln Ala Leu Lys Phe His 
            20                  25                  30          


Pro Asp Lys Asn Lys Ser Pro Gln Ala Glu Glu Lys Phe Lys Glu Val 
        35                  40                  45              


Ala Glu Ala Tyr Glu Val Leu Ser Asp Pro Lys Lys Arg Glu Ile Tyr 
    50                  55                  60                  


Asp Gln Phe Gly Glu Glu Gly Leu Lys Gly Gly Ala Gly Gly Thr Asp 
65                  70                  75                  80  


Gly Gln Gly Gly Thr Phe Arg Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ala Phe Phe Gly Gly Ser Asn Pro Phe Glu Ile Phe Phe 
            100                 105                 110         


Gly Arg Arg Met Gly Gly Gly Arg Asp Ser Glu Glu Met Glu Ile Asp 
        115                 120                 125             


Gly Asp Pro Phe Ser Ala Phe Gly Phe Ser Met Asn Gly Tyr Pro Arg 
    130                 135                 140                 


Asp Arg Asn Ser Val Gly Pro Ser Arg Leu Lys Gln Asp Pro Pro Val 
145                 150                 155                 160 


Ile His Glu Leu Arg Val Ser Leu Glu Glu Ile Tyr Ser Gly Cys Thr 
                165                 170                 175     


Lys Arg Met Lys Ile Ser Arg Lys Arg Leu Asn Ala Asp Gly Arg Ser 
            180                 185                 190         


Tyr Arg Ser Glu Asp Lys Ile Leu Thr Ile Glu Ile Lys Lys Gly Trp 
        195                 200                 205             


Lys Glu Gly Thr Lys Ile Thr Phe Pro Arg Glu Gly Asp Glu Thr Pro 
    210                 215                 220                 


Asn Ser Ile Pro Ala Asp Ile Val Phe Ile Ile Lys Asp Lys Asp His 
225                 230                 235                 240 


Pro Lys Phe Lys Arg Asp Gly Ser Asn Ile Ile Tyr Thr Ala Lys Ile 
                245                 250                 255     


Ser Leu Arg Glu Ala Leu Cys Gly Cys Ser Ile Asn Val Pro Thr Leu 
            260                 265                 270         


Asp Gly Arg Asn Ile Pro Met Ser Val Asn Asp Ile Val Lys Pro Gly 
        275                 280                 285             


Met Arg Arg Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro Lys Asn Pro 
    290                 295                 300                 


Asp Gln Arg Gly Asp Leu Leu Ile Glu Phe Glu Val Ser Phe Pro Asp 
305                 310                 315                 320 


Thr Ile Ser Ser Ser Ser Lys Glu Val Leu Arg Lys His Leu Pro Ala 
                325                 330                 335     


Ser 
    


<210>  263
<211>  2838
<212>  DNA
<213>  Homosapiens

<400>  263
gggtgggcgg gcggctgctc cggtccaggg gtggaggtcg gggccctgac ccgacgcagc     60

caggcggaag cgcggctgcc attggaggct gcttttacct gcgcggggcc cggggcgcaa    120

agtccgaggc gccgggggga ggaggcggcg gacggcagcg caggtgggcc cgcgctctcg    180

gccctgcaag atgcccctga agctgcgggg gaagaagaag gccaagtcca aggagaccgc    240

cgggctggtg gagggcgagc cgacgggcgc gggcggcggg agcctctcag cgtcccgggc    300

tcccgcacgc aggctggtct tccacgcgca gctggcgcac ggtagtgcca cgggccgagt    360

ggagggcttc tccagcatcc aggagctcta cgcccagatc gcgggcgcgt ttgaaatctc    420

gccgtcggag atcttatatt gcactttaaa cacacctaaa attgacatgg aaagactctt    480

aggaggacaa ctaggactag aagatttcat atttgcccat gtgaaaggaa tcgaaaaaga    540

agtgaatgtg tataaatctg aggattcact tggtctcacc attacagata atggtgttgg    600

ctatgctttt ataaagagaa ttaaagatgg tggtgttatt gactcagtta aaacaatctg    660

tgttggggat catattgaat ccataaatgg agaaaatatt gttgggtggc gtcactatga    720

tgttgctaag aagttaaagg aattaaaaaa ggaggaactc tttactatga agttaataga    780

acctaagaag gcatttgaaa tagagctgag gtcaaaggct ggaaagtcat caggagaaaa    840

aattggttgt ggaagggcaa cacttcgcct gagatcaaaa ggtcctgcca ccgtggaaga    900

aatgccttct gaaaccaaag caaaggcaat tgaaaagatt gatgatgttc ttgagttgta    960

catgggaatt cgagatattg atttagccac cacaatgttt gaagctggaa aggacaaagt   1020

aaatccagat gaatttgctg tggcacttga cgaaactctt ggagactttg cgttcccaga   1080

cgaatttgtc tttgatgttt ggggagtcat tggtgatgcc aaacgaagag gattatgatg   1140

tgtacactcc atctctgaag aaacaaccca tcgttctttt ttttctcttt tttaaaaagt   1200

cctataagat ctgtttttgg acacctttac taactctggt ttaatttcat gtgtatggaa   1260

tatattcttt gaaatataat tttggtaatt ttgatttctg ggcacttttt aacattgctg   1320

atgtagtatg cttaagagaa atgacctaaa taaggatcaa ttgtaatatt cattcaaaag   1380

gtttttaaaa gtaagtttta aggagtattt ctcgacagat gattttcttc tccattaata   1440

cccatgcttt gtttttcaca tataaataga tgatttcaat agctttgtag ttttttttca   1500

aaatcttaat gtaaactagg attggagtat gatttacctc atagtatctt cactgtgtta   1560

tcctagtttg aacaggatat gttcaggaaa tgaaaggtga attatgcccc ttattggtct   1620

agaagcattg gttttttttt gatcctctga gtaagggaag gaagattcct gtggcatgtt   1680

gatttctatg gccaactttc tctctttgta aaacaaagat tgattgattt tcttgtatgc   1740

ttctttatac atgctcttaa aacttgtggt tgaaatctgt gctgtgtgtg tgtgtctctg   1800

catgtgtaaa agaagggtaa aaaagagatg ggtagggtag aactacttgc atttgatttt   1860

tttttcagtc cttaaaacat tatttctttt tttcactcat agccactttt atgttacctt   1920

ttataagcac tccagggaag attttatatt tttttgtaga gtttttggaa agatatttac   1980

tcaaaataac tatgctttag aacttttttt tttttttttt ttttggttaa acagcagcac   2040

tttttagttc cctaaacttt agaagaaatg ctatcagaaa tagatttcct tccagtggaa   2100

agaaaggagg aagggagaat tgagaaaata tattagtcta ttattttaga gttctaatac   2160

actctaaatt atagagaaaa ttgagagtaa atgactgtct tatcactctt atttgacatt   2220

tcgtaggtgt aagagaaatg gaaatgaatg gtttcaacaa agatcattta atacagcaga   2280

gcatggcatg accaagcatc tttgtaaagt gttagatgga aaatgctgtg tgctgccatg   2340

gtaatcagaa ataataacct gttagggatg tattctagga aatcagaagt agttctcttt   2400

tcttgctgga ttattgctta gataactctt gttttctggt aaaactttag ttgtattgcc   2460

atccactcct ttttcaaatg agtttaatgc cataaagctg atattctttg tccgattaat   2520

ttgaaatctg cacagaagct gttttagtca ttaatgtgta acaaaagtag cttatagaat   2580

atggactgcc ttattgctgt tgcttatcat ttgaaaataa aatccagctc aggttgtaac   2640

ttgttggtac ttgtttagtg agttcgtttt ggaggttctg aaatacctat taattcttaa   2700

tattacctct cttggaaaga cacaaaaaaa gagctgttat ttttaggcat aagatgactt   2760

aggaggccca tagaaacgtt ctcgtttaaa caacaacaac aaaataaatt tatcagcact   2820

agaaaaaaaa aaaaaaaa                                                 2838


<210>  264
<211>  315
<212>  PRT
<213>  Homosapiens

<400>  264

Met Pro Leu Lys Leu Arg Gly Lys Lys Lys Ala Lys Ser Lys Glu Thr 
1               5                   10                  15      


Ala Gly Leu Val Glu Gly Glu Pro Thr Gly Ala Gly Gly Gly Ser Leu 
            20                  25                  30          


Ser Ala Ser Arg Ala Pro Ala Arg Arg Leu Val Phe His Ala Gln Leu 
        35                  40                  45              


Ala His Gly Ser Ala Thr Gly Arg Val Glu Gly Phe Ser Ser Ile Gln 
    50                  55                  60                  


Glu Leu Tyr Ala Gln Ile Ala Gly Ala Phe Glu Ile Ser Pro Ser Glu 
65                  70                  75                  80  


Ile Leu Tyr Cys Thr Leu Asn Thr Pro Lys Ile Asp Met Glu Arg Leu 
                85                  90                  95      


Leu Gly Gly Gln Leu Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
            100                 105                 110         


Gly Ile Glu Lys Glu Val Asn Val Tyr Lys Ser Glu Asp Ser Leu Gly 
        115                 120                 125             


Leu Thr Ile Thr Asp Asn Gly Val Gly Tyr Ala Phe Ile Lys Arg Ile 
    130                 135                 140                 


Lys Asp Gly Gly Val Ile Asp Ser Val Lys Thr Ile Cys Val Gly Asp 
145                 150                 155                 160 


His Ile Glu Ser Ile Asn Gly Glu Asn Ile Val Gly Trp Arg His Tyr 
                165                 170                 175     


Asp Val Ala Lys Lys Leu Lys Glu Leu Lys Lys Glu Glu Leu Phe Thr 
            180                 185                 190         


Met Lys Leu Ile Glu Pro Lys Lys Ala Phe Glu Ile Glu Leu Arg Ser 
        195                 200                 205             


Lys Ala Gly Lys Ser Ser Gly Glu Lys Ile Gly Cys Gly Arg Ala Thr 
    210                 215                 220                 


Leu Arg Leu Arg Ser Lys Gly Pro Ala Thr Val Glu Glu Met Pro Ser 
225                 230                 235                 240 


Glu Thr Lys Ala Lys Ala Ile Glu Lys Ile Asp Asp Val Leu Glu Leu 
                245                 250                 255     


Tyr Met Gly Ile Arg Asp Ile Asp Leu Ala Thr Thr Met Phe Glu Ala 
            260                 265                 270         


Gly Lys Asp Lys Val Asn Pro Asp Glu Phe Ala Val Ala Leu Asp Glu 
        275                 280                 285             


Thr Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp Val Trp 
    290                 295                 300                 


Gly Val Ile Gly Asp Ala Lys Arg Arg Gly Leu 
305                 310                 315 


<210>  265
<211>  1981
<212>  DNA
<213>  Homosapiens

<400>  265
gatttggtaa ccacctcaga gcctacccta tttattccca gcatggacct aaatccactt     60

cagccaaaaa tgaacaaaga aatgatgaag aacagagcct gtttctttct cagtggtgta    120

ctcagaaaat ggatgcaaga gtagaagctg atcctcgagg cttgcaaaag tggggttctt    180

tctgaaagtg aagccagcag ccaagagcca cccttcagaa gatagaagga agagcagctg    240

catgagtgat ggccacagca atgcatgggt cctgtctgtc cacgtagtcc tctccatctg    300

cccgtagctt gccaggtctc ctacccacac tggggaaatt ccagctgccg gccctctttg    360

ggttgcacct cccctttttg cacagggctc tattgggaaa gcagctgtca tgtgtctatt    420

tgaaagacaa gaaaccagtc tagttataga aaagagattt agattacatc agaataacaa    480

tgcaaatcat ttgtgcagtt cttagtacag aaaacagatt taggaacaaa aattgggagg    540

gttaaagaaa gtggtttttt attctgtcat caaaattgtt ttttaaaaac acatctgtag    600

taagataaat aattgtgtgc cgacttcata aacagaatga atgactgaat tcacacaatg    660

ttatttactg tttcagggca cacacacatg gtttccaagt ggtttcttgc cactttggcc    720

ttcaactggc cttgctattt tccattgagg ggtgtctgat tgtctcctcc acagccctga    780

gtctaagcaa aagcccatgg gttggttgac tggtgttctt gttgtccttg gaagtggaca    840

gactggcaga tgtggggcta gtggggaaga ttctcgtaaa cactttattt gttgtaagaa    900

ctccagttgg aatgtggctt ccaatcatgg gaggaggact gctttagaac aggaaacttt    960

ctataataat accaatacaa ccaaagacta ttattctgaa cagaaaacaa gaaatacagc   1020

tggagctatt tcctatctac ctgatgaagg gcactaccag gcggtcactc tggctctgtc   1080

caccgatgcc tgtgcccact ttgtgcgacg tagcttccat ggagacaaga gcaatggtaa   1140

tggaagaaga aagtctggat gtactcttgc agaagcagaa agcttcatgg aacaatatta   1200

atcttctggt catctctgtg ctggtctagt tgcccataaa gttgtcagat tgactttgga   1260

tttaaagcct gaaaatgagt cccaaggaaa tccgttgaca tgaggcccaa ggaagacagt   1320

ttttggaagg ggcaaggagg gacagttctc tgctccactg aagctaggta tggccatgtg   1380

acccatgttg ccagtgaaac aggaggagaa gggacatctg ggtggaaaca tttaagagtc   1440

aagtgtattt ctccatactc tctttctttg gctttggcag tgatgaaggt caatccaatt   1500

acagttgatt cttgaacaac agaggtttga actgtgtggg tcaacctata cgtggatttt   1560

cttctgcctc tgccacctct gagacagcaa gaccaatcct tccttttcct ccttctcctc   1620

agcctataca atgtaaaaat gacaaggatg aagaccttta tgatgattca cgtccactta   1680

atgaacaacg tacctttcac ttcccaccat gattctgagg cctcccgagc catgtggaac   1740

tgtaagtgca attaaacctc tttttcttcc cagtcttggg tatgtcttta tcagcagtgt   1800

gaaaatggac taatacagta aataggtacc agtagagtgg ggcattgctg aaaagatatc   1860

tgaaaatgtg gaagcaactt ttgaactggg taacaggcag aggttggaag agtttggagg   1920

gctcagaaga agacaggaaa atgtgggaaa gtttggaact tctagagatt tgttgaatgg   1980

c                                                                   1981


<210>  266
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  266

Met Gly Trp Leu Thr Gly Val Leu Val Val Leu Gly Ser Gly Gln Thr 
1               5                   10                  15      


Gly Arg Cys Gly Ala Ser Gly Glu Asp Ser Arg Lys His Phe Ile Cys 
            20                  25                  30          


Cys Lys Asn Ser Ser Trp Asn Val Ala Ser Asn His Gly Arg Arg Thr 
        35                  40                  45              


Ala Leu Glu Gln Glu Thr Phe Tyr Asn Asn Thr Asn Thr Thr Lys Asp 
    50                  55                  60                  


Tyr Tyr Ser Glu Gln Lys Thr Arg Asn Thr Ala Gly Ala Ile Ser Tyr 
65                  70                  75                  80  


Leu Pro Asp Glu Gly His Tyr Gln Ala Val Thr Leu Ala Leu Ser Thr 
                85                  90                  95      


Asp Ala Cys Ala His Phe Val Arg Arg Ser Phe His Gly Asp Lys Ser 
            100                 105                 110         


Asn Gly Asn Gly Arg Arg Lys Ser Gly Cys Thr Leu Ala Glu Ala Glu 
        115                 120                 125             


Ser Phe Met Glu Gln Tyr 
    130                 


<210>  267
<211>  1459
<212>  DNA
<213>  Homosapiens

<400>  267
cggcgggctg gcctggcgcg ctgcggcgct cgctcacccg ctcccgagga agggcagtgg     60

gccccgccgc cgcctcccaa tggcgaggct gcgggattgc ctgccccgcc tgatgctcac    120

gctccggtcc ctgctcttct ggtccctggt ctactgctac tgcgggctct gcgcctccat    180

ccacctgctc aaacttttgt ggagcctcgg caaggggccg gcgcagacct tccggcggcc    240

cgcccgggag caccctcccg cgtgcctgag cgacccctcc ttgggcaccc actgctacgt    300

gcggatcaag gattcagggt taagatttca ctatgttgct gctggagaaa gaggcaaacc    360

acttatgctg ctgcttcatg gatttccaga attctggtat tcttggcgtt accaactgag    420

agaatttaaa agtgaatatc gagttgtagc actggatttg agaggttatg gagaaacaga    480

tgctcccatt catcgacaga attataaatt ggattgtcta attacagata taaaggatat    540

tttagattct ttagggtata gcaaatgtgt tcttattggc catgactggg ggggcatgat    600

tgcttggcta attgccatct gttatcctga aatggtgatg aagcttattg ttattaactt    660

ccctcatcca aatgtattta cagaatatat tttacgacac cctgctcagc tgttgaaatc    720

cagttattat tacttcttcc aaataccatg gttcccagaa tttatgttct caataaatga    780

tttcaaggtt ttgaaacatc tgtttaccag tcacagcact ggcattggaa gaaaaggatg    840

ccaattaaca acagaggatc ttgaagctta tatttatgtc ttttctcagc ctggagcatt    900

aagtggccca attaaccatt accgaaatat cttcagctgc ctgcctctca aacatcacat    960

ggtgaccact ccaacactac tactgtgggg agagaatgac gcattcatgg aggttgagat   1020

ggctgaagtc acaaagattt ttgttaaaaa ctatttcagg ctaactattt tgtcagaagc   1080

cagtcattgg cttcagcaag accaacctga catagtgaac aaattgatat ggacatttct   1140

aaaagaagaa acaagaaaaa aagattgact tttctttatc ttctatgaag ggtctgtaat   1200

gaaatctcta aataattttt aaaaattgtt catcaacttc tttatgtttt attagaaaaa   1260

aactgtttta atgtgcttta tcataaataa atatcctgac aaatggtatt gaaaaaaatc   1320

tgagatcatg tgaacatata atacaatgtt gattttcttc tggtgtattt tgcacagaca   1380

agcatctgcc ttaaaatata tacacttgta caaaaaggga aaaaaaaaaa aaaaaaaaaa   1440

aaaaaaaaaa aaaaaaaaa                                                1459


<210>  268
<211>  362
<212>  PRT
<213>  Homosapiens

<400>  268

Met Ala Arg Leu Arg Asp Cys Leu Pro Arg Leu Met Leu Thr Leu Arg 
1               5                   10                  15      


Ser Leu Leu Phe Trp Ser Leu Val Tyr Cys Tyr Cys Gly Leu Cys Ala 
            20                  25                  30          


Ser Ile His Leu Leu Lys Leu Leu Trp Ser Leu Gly Lys Gly Pro Ala 
        35                  40                  45              


Gln Thr Phe Arg Arg Pro Ala Arg Glu His Pro Pro Ala Cys Leu Ser 
    50                  55                  60                  


Asp Pro Ser Leu Gly Thr His Cys Tyr Val Arg Ile Lys Asp Ser Gly 
65                  70                  75                  80  


Leu Arg Phe His Tyr Val Ala Ala Gly Glu Arg Gly Lys Pro Leu Met 
                85                  90                  95      


Leu Leu Leu His Gly Phe Pro Glu Phe Trp Tyr Ser Trp Arg Tyr Gln 
            100                 105                 110         


Leu Arg Glu Phe Lys Ser Glu Tyr Arg Val Val Ala Leu Asp Leu Arg 
        115                 120                 125             


Gly Tyr Gly Glu Thr Asp Ala Pro Ile His Arg Gln Asn Tyr Lys Leu 
    130                 135                 140                 


Asp Cys Leu Ile Thr Asp Ile Lys Asp Ile Leu Asp Ser Leu Gly Tyr 
145                 150                 155                 160 


Ser Lys Cys Val Leu Ile Gly His Asp Trp Gly Gly Met Ile Ala Trp 
                165                 170                 175     


Leu Ile Ala Ile Cys Tyr Pro Glu Met Val Met Lys Leu Ile Val Ile 
            180                 185                 190         


Asn Phe Pro His Pro Asn Val Phe Thr Glu Tyr Ile Leu Arg His Pro 
        195                 200                 205             


Ala Gln Leu Leu Lys Ser Ser Tyr Tyr Tyr Phe Phe Gln Ile Pro Trp 
    210                 215                 220                 


Phe Pro Glu Phe Met Phe Ser Ile Asn Asp Phe Lys Val Leu Lys His 
225                 230                 235                 240 


Leu Phe Thr Ser His Ser Thr Gly Ile Gly Arg Lys Gly Cys Gln Leu 
                245                 250                 255     


Thr Thr Glu Asp Leu Glu Ala Tyr Ile Tyr Val Phe Ser Gln Pro Gly 
            260                 265                 270         


Ala Leu Ser Gly Pro Ile Asn His Tyr Arg Asn Ile Phe Ser Cys Leu 
        275                 280                 285             


Pro Leu Lys His His Met Val Thr Thr Pro Thr Leu Leu Leu Trp Gly 
    290                 295                 300                 


Glu Asn Asp Ala Phe Met Glu Val Glu Met Ala Glu Val Thr Lys Ile 
305                 310                 315                 320 


Phe Val Lys Asn Tyr Phe Arg Leu Thr Ile Leu Ser Glu Ala Ser His 
                325                 330                 335     


Trp Leu Gln Gln Asp Gln Pro Asp Ile Val Asn Lys Leu Ile Trp Thr 
            340                 345                 350         


Phe Leu Lys Glu Glu Thr Arg Lys Lys Asp 
        355                 360         


<210>  269
<211>  1438
<212>  DNA
<213>  Homosapiens

<400>  269
gggggcgcac gctcttcctg ggtcaagagc cggctcggtt ctgggattct gaggctcccc     60

accgcggtcc ggcttctctg ggagactgtc tacaaaccga cgagaggcgt caacctttta    120

ccctaggggg cggatttggg taggagccga gcgttcggtc ggaaacgccc ccttcttcct    180

cctgggcggg gcaagtgagg ccaagtactg ggcctccagg gcgtcgtacc tctgtgagac    240

atggctcgct gtggggaagg cagtgcggcc cccatggtac ttctggggtc cgctggagtt    300

tgcagtaagg ggttgcaaag gaaggggccg tgtgagcggc gccggctgaa ggcgacggtg    360

tcggagcagc tcagccagga tttgctcagg cttctaaggg aagaattcca tacagatgtt    420

accttctctg tgggttgtac tttgttcaaa gcacacaaag cagtcctttt agcaagagtt    480

cctgacttct attttcatac tattggacag acatcaaata gtttaacaaa tcaggagcct    540

attgctgtgg agaatgttga agctttagaa tttagaacgt ttttacagat tatatattca    600

tcaaacagaa acataaaaaa ctatgaagag gaaattctta ggaaaaagat aatggagatt    660

gggatatcac aaaagcaact tgacatcagt tttccaaagt gtgaaaactc atctgattgt    720

tctcttcaga agcatgaaat tccagaggat atcagtgaca gagatgatga tttcatttcc    780

aatgataatt atgacttgga gcctgcatct gaattaggag aagatttatt gaagctttat    840

gtgaaacctg gttgcccaga tattgatatt tttgttgatg gaaaacgttt taaagctcac    900

agggccattt tgagtgccag atctagttat tttgctgcaa tgctgagtgg ctgttgggct    960

gaaagctccc aagagtacgt tactcttcaa ggtataagcc atgtagaact gaatgttatg   1020

atgcatttta tatatggagg aactctggac attccagaca aaactaatgt tggtcagata   1080

ctcaatatgg ctgatatgta tggactagaa ggattaaaag aagtagcaat ctatatttta   1140

agaagagatt actgtaattt ctttcagaag cctgttccca gaacattgac gtctatacta   1200

gaatgcctga ttattgctca ttcagttgga gtggaaagtc tttttgctga ctgcatgaag   1260

tggattgtaa agcattttgc aaggttttgg tctgagagaa gctttgcaaa tatacctcct   1320

gagattcaga aaagttgtct taatatgttg attcagtcct tagtaaatat aacctgaata   1380

ctcttttgtg tgtttgccat taaaaagttt atgcaaaaaa aaaaaaaaaa aaaaaaaa     1438


<210>  270
<211>  378
<212>  PRT
<213>  Homosapiens

<400>  270

Met Ala Arg Cys Gly Glu Gly Ser Ala Ala Pro Met Val Leu Leu Gly 
1               5                   10                  15      


Ser Ala Gly Val Cys Ser Lys Gly Leu Gln Arg Lys Gly Pro Cys Glu 
            20                  25                  30          


Arg Arg Arg Leu Lys Ala Thr Val Ser Glu Gln Leu Ser Gln Asp Leu 
        35                  40                  45              


Leu Arg Leu Leu Arg Glu Glu Phe His Thr Asp Val Thr Phe Ser Val 
    50                  55                  60                  


Gly Cys Thr Leu Phe Lys Ala His Lys Ala Val Leu Leu Ala Arg Val 
65                  70                  75                  80  


Pro Asp Phe Tyr Phe His Thr Ile Gly Gln Thr Ser Asn Ser Leu Thr 
                85                  90                  95      


Asn Gln Glu Pro Ile Ala Val Glu Asn Val Glu Ala Leu Glu Phe Arg 
            100                 105                 110         


Thr Phe Leu Gln Ile Ile Tyr Ser Ser Asn Arg Asn Ile Lys Asn Tyr 
        115                 120                 125             


Glu Glu Glu Ile Leu Arg Lys Lys Ile Met Glu Ile Gly Ile Ser Gln 
    130                 135                 140                 


Lys Gln Leu Asp Ile Ser Phe Pro Lys Cys Glu Asn Ser Ser Asp Cys 
145                 150                 155                 160 


Ser Leu Gln Lys His Glu Ile Pro Glu Asp Ile Ser Asp Arg Asp Asp 
                165                 170                 175     


Asp Phe Ile Ser Asn Asp Asn Tyr Asp Leu Glu Pro Ala Ser Glu Leu 
            180                 185                 190         


Gly Glu Asp Leu Leu Lys Leu Tyr Val Lys Pro Gly Cys Pro Asp Ile 
        195                 200                 205             


Asp Ile Phe Val Asp Gly Lys Arg Phe Lys Ala His Arg Ala Ile Leu 
    210                 215                 220                 


Ser Ala Arg Ser Ser Tyr Phe Ala Ala Met Leu Ser Gly Cys Trp Ala 
225                 230                 235                 240 


Glu Ser Ser Gln Glu Tyr Val Thr Leu Gln Gly Ile Ser His Val Glu 
                245                 250                 255     


Leu Asn Val Met Met His Phe Ile Tyr Gly Gly Thr Leu Asp Ile Pro 
            260                 265                 270         


Asp Lys Thr Asn Val Gly Gln Ile Leu Asn Met Ala Asp Met Tyr Gly 
        275                 280                 285             


Leu Glu Gly Leu Lys Glu Val Ala Ile Tyr Ile Leu Arg Arg Asp Tyr 
    290                 295                 300                 


Cys Asn Phe Phe Gln Lys Pro Val Pro Arg Thr Leu Thr Ser Ile Leu 
305                 310                 315                 320 


Glu Cys Leu Ile Ile Ala His Ser Val Gly Val Glu Ser Leu Phe Ala 
                325                 330                 335     


Asp Cys Met Lys Trp Ile Val Lys His Phe Ala Arg Phe Trp Ser Glu 
            340                 345                 350         


Arg Ser Phe Ala Asn Ile Pro Pro Glu Ile Gln Lys Ser Cys Leu Asn 
        355                 360                 365             


Met Leu Ile Gln Ser Leu Val Asn Ile Thr 
    370                 375             


<210>  271
<211>  4556
<212>  DNA
<213>  Homosapiens

<400>  271
atggcgtctc agcttcaaga aaaatgtatt gcatttattg tagacaactt ctccaagatt     60

attcagagtg aaaattttgc tcttctttta cagtcacaag caatgagcag cacagccgat    120

ctgttggaca caattttaaa agcaattgaa gaaaatatca ccactgaaaa tagctgctct    180

cttcttatgg ctctggacac actgctgaac tctgacagta caaaggaaat gggttttacg    240

tgcaagatcc aggctctgcg tgataagctg tggatcttcc tggttcagtc tttctatgct    300

gttcgtcaca cagaaagctg gaagctgatg agcacagatg atcaacagaa aatccaagca    360

gctgcatttg acaaaggtga tgatcgaaga cttggcaaaa agcctatatt cagtagctcg    420

cagcaaagga aacaagtttc tgactctggt gatataaaaa tcaaatcttg gaggggaaat    480

aacaagaaag agtgttggag ttatctctct actaataaaa agatgaaatc tgatggatta    540

ggagcatctg gacattcgtc aagtaccaat agaaatagta taaataaaac tctgaagcaa    600

gatgatgtaa aggaaaaaga tggtacaaaa atagcatcta agattacaaa agaactaaaa    660

actgggggaa aaaatgtttc tggaaagccc aaaactgtaa caaaatccaa aacagaaaat    720

ggtgataagg cacggttgga aaacatgtca cctagacaag ttgtagaaag atcagcaaca    780

gcagcagcag cagcaactgg acagaagaat ttactaaatg gaaaaggagt gagaaatcag    840

gaagggcaaa tttcaggtgc cagacccaag gtactcacag gaaacttaaa tgtgcaagcc    900

aaagcaaagc ctttgaagaa agctacaggg aaggattcac catgcctcag catcgcagga    960

ccctccagca gatccacaga ttcaagtatg gaattctcaa tttccactga atgtctggat   1020

gaaccgaaag aaaatggatc aacagaagaa gaaaagcctt ctggacataa actatccttt   1080

tgtgattctc caggacagat gatgaaaaac agtgtagata gtgtcaaaaa ttccactgta   1140

gccataaaat ctcgacctgt ttcaagagtt accaatggaa cttccaataa aaaaagtatt   1200

catgaacaag acactaatgt aaataacagt gtactaaaga aagtcagtgg caaaggatgt   1260

agtgagccag taccacaggc aattttgaag aaaagaggaa ctagcaatgg atgtactgca   1320

gctcagcaga ggacaaagag taccccatct aatcttacta aaactcaagg atcccaagga   1380

gagtcaccaa actcagtaaa atcttcagtc tcttcaaggc agtctgatga aaatgtggca   1440

aagttggacc acaatacaac tacagagaaa caagcaccta agagaaaaat ggtcaagcaa   1500

gtacacacag ctttgcctaa ggttaatgca aaaatagtgg caatgcctaa aaatctaaat   1560

cagtcaaaga aaggtgaaac tttgaataat aaagattcaa aacagaaaat gcctcctgga   1620

caggttatat caaaaactca gccttcctcc caaagacctt taaaacatga aacatctact   1680

gtccaaaaaa gtatgtttca tgatgtgcgt gataataaca acaaggacag tgtttctgaa   1740

cagaagcctc acaaacctct cattaatctt gcatctgaaa taagtgatgc agaagcactc   1800

cagtcatcct gcaggcctga cccacaaaag ccattaaacg atcaagaaaa agagaagttg   1860

gcgttagaat gccaaaatat ttcaaagctg gataaatcat taaaacacga actggaatca   1920

aaacagattt gtttagataa aagtgaaaca aaatttccca atcacaaaga aacagatgat   1980

tgcgatgcag ctaacatatg ttgtcattct gttgggagtg ataatgtaaa ttcaaaattt   2040

tatagcacca cagccctaaa atacatggtt tcaaatccaa atgaaaactc cttgaactct   2100

aatccagttt gtgatttaga ctcaacaagt gcagggcaaa tccatttgat atcagatagg   2160

gagaaccaag tagggagaaa agatacaaac aaacaatcaa gtattaaatg tgtggaagat   2220

gtttcactgt gtaatcctga aaggacaaat ggtaccttaa attctgctca agaagacaaa   2280

aaatcgaaag ttcctgtgga aggactgaca attcctagta agttgtcaga tgaatctgct   2340

atggatgaag acaaacatgc tacagcagac tcagatgtat cttccaagtg tttttcggga   2400

cagctatcag aaaaaaattc tcctaaaaat atggaaacat cagaatctcc agagagccat   2460

gaaactccag aaactccatt tgtgggtcac tggaatttga gtactggtgt tctgcatcag   2520

cgagagagtc ctgaatctga cactggcagt gctaccacct cctccgatga cataaagccc   2580

agatctgaag actatgatgc tggagggtct caggatgatg atgggtcaaa tgacagaggt   2640

atctctaaat gtggcactat gctgtgccat gattttcttg gaagaagtag cagtgatacc   2700

agtactcctg aagaattaaa aatttatgat agtaatttaa gaattgaagt aaaaatgaaa   2760

aagcaaagta ataatgatct tttccaagtt aattcaacga gtgatgatga aatccctagg   2820

aaaaggccag aaatttggtc tcgatctgca atagttcact ctagggaaag agaaaatatt   2880

ccacgaggca gtgtccagtt tgctcaggaa atagatcagg tatcttcttc agcagatgaa   2940

acagaagatg aaagatctga agctgaaaac gttgcagaaa atttctctat atctaaccca   3000

gctcctcagc agtttcaggg aataattaat ttagcttttg aagatgcaac tgaaaatgaa   3060

tgtcgtgaat tttctgcaac taaaaagttt aaaaggtcag ttttactttc agtcgatgaa   3120

tgtgaagagc tgggatcaga tgaaggagaa gtccatactc cctttcaggc ttctgtagat   3180

tctttttcac cttctgatgt ttttgatggc atttctcatg aacatcatgg aaggacctgc   3240

tattccagat tctcacgaga aagtgaagat aatattttag aatgtaaaca aaataaaggc   3300

aatagtgtat gtaaaaatga aagcactgtc ttggatctta gtagcattga ctcttcaaga   3360

aaaaataaac agagtgtttc agccacagaa aaaaagaaca caatagacgt cctatccagt   3420

agaagcagac agcttcttcg agaagataaa aaagtaaaca atggaagcaa tgtggaaaat   3480

gacattcagc aacgcagcaa attcttggat agtgatgtaa aatctcaaga aagaccatgt   3540

cacttggatc ttcatcaaag agaacccaat tctgacatac caaagaacag ctctacaaaa   3600

tctctagact cctttcggag tcaagttctg cctcaggaag gtccagtgaa agagagccat   3660

tctacaacta ctgaaaaagc taatattgct ttatctgcag gagacataga tgattgtgac   3720

acactggcac aaacccgcat gtatgaccat cggccttcaa aaaccctgtc tccaatatat   3780

gagatggatg taatagaagc atttgagcag aaagtggaat cagaaacaca tgttacagat   3840

atggattttg aagatgacca acattttgca aaacaagatt ggacactact aaagcaactg   3900

ctctctgaac aggattcaaa cttagatgtt acaaattccg ttcctgaaga cttaagttta   3960

gcacagtatc taatcaatca gacactactt ttagcacgag atagctcaaa acctcagggt   4020

ataacacata ttgacacttt gaacagatgg agtgaactaa catctccact tgattcctca   4080

gcgagcatca ccatggctag tttttcctct gaagattgtt cgcctcaagg cgagtggaca   4140

attctggaac tggaaactca gcattaagtg ttaacatttt ggaaaaattt atgccactcc   4200

tttatttttt gatgcctata ttatatccaa atgataattg cattagccgg atataaactt   4260

tctttaatat tgagtctttc caatttaatg aggtaaacat agtttattta ttaatatatc   4320

acatatagaa aaatgttttt ctaaagtttt tgagcatgtt ttctctaatt attagagaaa   4380

ttagaagact tataaggaaa ccctagcttc agttttcctt tcctagctga tgatttgttc   4440

acttaatcat tattcaagaa tttaaaatgt gaatgcagaa gtagatcagt ccctttactt   4500

tttgctctgc atagggtaac atagtaattt aacaataaaa acttaccgtg cttgtg       4556


<210>  272
<211>  1388
<212>  PRT
<213>  Homosapiens

<400>  272

Met Ala Ser Gln Leu Gln Glu Lys Cys Ile Ala Phe Ile Val Asp Asn 
1               5                   10                  15      


Phe Ser Lys Ile Ile Gln Ser Glu Asn Phe Ala Leu Leu Leu Gln Ser 
            20                  25                  30          


Gln Ala Met Ser Ser Thr Ala Asp Leu Leu Asp Thr Ile Leu Lys Ala 
        35                  40                  45              


Ile Glu Glu Asn Ile Thr Thr Glu Asn Ser Cys Ser Leu Leu Met Ala 
    50                  55                  60                  


Leu Asp Thr Leu Leu Asn Ser Asp Ser Thr Lys Glu Met Gly Phe Thr 
65                  70                  75                  80  


Cys Lys Ile Gln Ala Leu Arg Asp Lys Leu Trp Ile Phe Leu Val Gln 
                85                  90                  95      


Ser Phe Tyr Ala Val Arg His Thr Glu Ser Trp Lys Leu Met Ser Thr 
            100                 105                 110         


Asp Asp Gln Gln Lys Ile Gln Ala Ala Ala Phe Asp Lys Gly Asp Asp 
        115                 120                 125             


Arg Arg Leu Gly Lys Lys Pro Ile Phe Ser Ser Ser Gln Gln Arg Lys 
    130                 135                 140                 


Gln Val Ser Asp Ser Gly Asp Ile Lys Ile Lys Ser Trp Arg Gly Asn 
145                 150                 155                 160 


Asn Lys Lys Glu Cys Trp Ser Tyr Leu Ser Thr Asn Lys Lys Met Lys 
                165                 170                 175     


Ser Asp Gly Leu Gly Ala Ser Gly His Ser Ser Ser Thr Asn Arg Asn 
            180                 185                 190         


Ser Ile Asn Lys Thr Leu Lys Gln Asp Asp Val Lys Glu Lys Asp Gly 
        195                 200                 205             


Thr Lys Ile Ala Ser Lys Ile Thr Lys Glu Leu Lys Thr Gly Gly Lys 
    210                 215                 220                 


Asn Val Ser Gly Lys Pro Lys Thr Val Thr Lys Ser Lys Thr Glu Asn 
225                 230                 235                 240 


Gly Asp Lys Ala Arg Leu Glu Asn Met Ser Pro Arg Gln Val Val Glu 
                245                 250                 255     


Arg Ser Ala Thr Ala Ala Ala Ala Ala Thr Gly Gln Lys Asn Leu Leu 
            260                 265                 270         


Asn Gly Lys Gly Val Arg Asn Gln Glu Gly Gln Ile Ser Gly Ala Arg 
        275                 280                 285             


Pro Lys Val Leu Thr Gly Asn Leu Asn Val Gln Ala Lys Ala Lys Pro 
    290                 295                 300                 


Leu Lys Lys Ala Thr Gly Lys Asp Ser Pro Cys Leu Ser Ile Ala Gly 
305                 310                 315                 320 


Pro Ser Ser Arg Ser Thr Asp Ser Ser Met Glu Phe Ser Ile Ser Thr 
                325                 330                 335     


Glu Cys Leu Asp Glu Pro Lys Glu Asn Gly Ser Thr Glu Glu Glu Lys 
            340                 345                 350         


Pro Ser Gly His Lys Leu Ser Phe Cys Asp Ser Pro Gly Gln Met Met 
        355                 360                 365             


Lys Asn Ser Val Asp Ser Val Lys Asn Ser Thr Val Ala Ile Lys Ser 
    370                 375                 380                 


Arg Pro Val Ser Arg Val Thr Asn Gly Thr Ser Asn Lys Lys Ser Ile 
385                 390                 395                 400 


His Glu Gln Asp Thr Asn Val Asn Asn Ser Val Leu Lys Lys Val Ser 
                405                 410                 415     


Gly Lys Gly Cys Ser Glu Pro Val Pro Gln Ala Ile Leu Lys Lys Arg 
            420                 425                 430         


Gly Thr Ser Asn Gly Cys Thr Ala Ala Gln Gln Arg Thr Lys Ser Thr 
        435                 440                 445             


Pro Ser Asn Leu Thr Lys Thr Gln Gly Ser Gln Gly Glu Ser Pro Asn 
    450                 455                 460                 


Ser Val Lys Ser Ser Val Ser Ser Arg Gln Ser Asp Glu Asn Val Ala 
465                 470                 475                 480 


Lys Leu Asp His Asn Thr Thr Thr Glu Lys Gln Ala Pro Lys Arg Lys 
                485                 490                 495     


Met Val Lys Gln Val His Thr Ala Leu Pro Lys Val Asn Ala Lys Ile 
            500                 505                 510         


Val Ala Met Pro Lys Asn Leu Asn Gln Ser Lys Lys Gly Glu Thr Leu 
        515                 520                 525             


Asn Asn Lys Asp Ser Lys Gln Lys Met Pro Pro Gly Gln Val Ile Ser 
    530                 535                 540                 


Lys Thr Gln Pro Ser Ser Gln Arg Pro Leu Lys His Glu Thr Ser Thr 
545                 550                 555                 560 


Val Gln Lys Ser Met Phe His Asp Val Arg Asp Asn Asn Asn Lys Asp 
                565                 570                 575     


Ser Val Ser Glu Gln Lys Pro His Lys Pro Leu Ile Asn Leu Ala Ser 
            580                 585                 590         


Glu Ile Ser Asp Ala Glu Ala Leu Gln Ser Ser Cys Arg Pro Asp Pro 
        595                 600                 605             


Gln Lys Pro Leu Asn Asp Gln Glu Lys Glu Lys Leu Ala Leu Glu Cys 
    610                 615                 620                 


Gln Asn Ile Ser Lys Leu Asp Lys Ser Leu Lys His Glu Leu Glu Ser 
625                 630                 635                 640 


Lys Gln Ile Cys Leu Asp Lys Ser Glu Thr Lys Phe Pro Asn His Lys 
                645                 650                 655     


Glu Thr Asp Asp Cys Asp Ala Ala Asn Ile Cys Cys His Ser Val Gly 
            660                 665                 670         


Ser Asp Asn Val Asn Ser Lys Phe Tyr Ser Thr Thr Ala Leu Lys Tyr 
        675                 680                 685             


Met Val Ser Asn Pro Asn Glu Asn Ser Leu Asn Ser Asn Pro Val Cys 
    690                 695                 700                 


Asp Leu Asp Ser Thr Ser Ala Gly Gln Ile His Leu Ile Ser Asp Arg 
705                 710                 715                 720 


Glu Asn Gln Val Gly Arg Lys Asp Thr Asn Lys Gln Ser Ser Ile Lys 
                725                 730                 735     


Cys Val Glu Asp Val Ser Leu Cys Asn Pro Glu Arg Thr Asn Gly Thr 
            740                 745                 750         


Leu Asn Ser Ala Gln Glu Asp Lys Lys Ser Lys Val Pro Val Glu Gly 
        755                 760                 765             


Leu Thr Ile Pro Ser Lys Leu Ser Asp Glu Ser Ala Met Asp Glu Asp 
    770                 775                 780                 


Lys His Ala Thr Ala Asp Ser Asp Val Ser Ser Lys Cys Phe Ser Gly 
785                 790                 795                 800 


Gln Leu Ser Glu Lys Asn Ser Pro Lys Asn Met Glu Thr Ser Glu Ser 
                805                 810                 815     


Pro Glu Ser His Glu Thr Pro Glu Thr Pro Phe Val Gly His Trp Asn 
            820                 825                 830         


Leu Ser Thr Gly Val Leu His Gln Arg Glu Ser Pro Glu Ser Asp Thr 
        835                 840                 845             


Gly Ser Ala Thr Thr Ser Ser Asp Asp Ile Lys Pro Arg Ser Glu Asp 
    850                 855                 860                 


Tyr Asp Ala Gly Gly Ser Gln Asp Asp Asp Gly Ser Asn Asp Arg Gly 
865                 870                 875                 880 


Ile Ser Lys Cys Gly Thr Met Leu Cys His Asp Phe Leu Gly Arg Ser 
                885                 890                 895     


Ser Ser Asp Thr Ser Thr Pro Glu Glu Leu Lys Ile Tyr Asp Ser Asn 
            900                 905                 910         


Leu Arg Ile Glu Val Lys Met Lys Lys Gln Ser Asn Asn Asp Leu Phe 
        915                 920                 925             


Gln Val Asn Ser Thr Ser Asp Asp Glu Ile Pro Arg Lys Arg Pro Glu 
    930                 935                 940                 


Ile Trp Ser Arg Ser Ala Ile Val His Ser Arg Glu Arg Glu Asn Ile 
945                 950                 955                 960 


Pro Arg Gly Ser Val Gln Phe Ala Gln Glu Ile Asp Gln Val Ser Ser 
                965                 970                 975     


Ser Ala Asp Glu Thr Glu Asp Glu Arg Ser Glu Ala Glu Asn Val Ala 
            980                 985                 990         


Glu Asn Phe Ser Ile Ser Asn Pro  Ala Pro Gln Gln Phe  Gln Gly Ile 
        995                 1000                 1005             


Ile Asn  Leu Ala Phe Glu Asp  Ala Thr Glu Asn Glu  Cys Arg Glu 
    1010                 1015                 1020             


Phe Ser  Ala Thr Lys Lys Phe  Lys Arg Ser Val Leu  Leu Ser Val 
    1025                 1030                 1035             


Asp Glu  Cys Glu Glu Leu Gly  Ser Asp Glu Gly Glu  Val His Thr 
    1040                 1045                 1050             


Pro Phe  Gln Ala Ser Val Asp  Ser Phe Ser Pro Ser  Asp Val Phe 
    1055                 1060                 1065             


Asp Gly  Ile Ser His Glu His  His Gly Arg Thr Cys  Tyr Ser Arg 
    1070                 1075                 1080             


Phe Ser  Arg Glu Ser Glu Asp  Asn Ile Leu Glu Cys  Lys Gln Asn 
    1085                 1090                 1095             


Lys Gly  Asn Ser Val Cys Lys  Asn Glu Ser Thr Val  Leu Asp Leu 
    1100                 1105                 1110             


Ser Ser  Ile Asp Ser Ser Arg  Lys Asn Lys Gln Ser  Val Ser Ala 
    1115                 1120                 1125             


Thr Glu  Lys Lys Asn Thr Ile  Asp Val Leu Ser Ser  Arg Ser Arg 
    1130                 1135                 1140             


Gln Leu  Leu Arg Glu Asp Lys  Lys Val Asn Asn Gly  Ser Asn Val 
    1145                 1150                 1155             


Glu Asn  Asp Ile Gln Gln Arg  Ser Lys Phe Leu Asp  Ser Asp Val 
    1160                 1165                 1170             


Lys Ser  Gln Glu Arg Pro Cys  His Leu Asp Leu His  Gln Arg Glu 
    1175                 1180                 1185             


Pro Asn  Ser Asp Ile Pro Lys  Asn Ser Ser Thr Lys  Ser Leu Asp 
    1190                 1195                 1200             


Ser Phe  Arg Ser Gln Val Leu  Pro Gln Glu Gly Pro  Val Lys Glu 
    1205                 1210                 1215             


Ser His  Ser Thr Thr Thr Glu  Lys Ala Asn Ile Ala  Leu Ser Ala 
    1220                 1225                 1230             


Gly Asp  Ile Asp Asp Cys Asp  Thr Leu Ala Gln Thr  Arg Met Tyr 
    1235                 1240                 1245             


Asp His  Arg Pro Ser Lys Thr  Leu Ser Pro Ile Tyr  Glu Met Asp 
    1250                 1255                 1260             


Val Ile  Glu Ala Phe Glu Gln  Lys Val Glu Ser Glu  Thr His Val 
    1265                 1270                 1275             


Thr Asp  Met Asp Phe Glu Asp  Asp Gln His Phe Ala  Lys Gln Asp 
    1280                 1285                 1290             


Trp Thr  Leu Leu Lys Gln Leu  Leu Ser Glu Gln Asp  Ser Asn Leu 
    1295                 1300                 1305             


Asp Val  Thr Asn Ser Val Pro  Glu Asp Leu Ser Leu  Ala Gln Tyr 
    1310                 1315                 1320             


Leu Ile  Asn Gln Thr Leu Leu  Leu Ala Arg Asp Ser  Ser Lys Pro 
    1325                 1330                 1335             


Gln Gly  Ile Thr His Ile Asp  Thr Leu Asn Arg Trp  Ser Glu Leu 
    1340                 1345                 1350             


Thr Ser  Pro Leu Asp Ser Ser  Ala Ser Ile Thr Met  Ala Ser Phe 
    1355                 1360                 1365             


Ser Ser  Glu Asp Cys Ser Pro  Gln Gly Glu Trp Thr  Ile Leu Glu 
    1370                 1375                 1380             


Leu Glu  Thr Gln His 
    1385             


<210>  273
<211>  751
<212>  DNA
<213>  Homosapiens

<400>  273
accctgagcg gtctctgagg acctggtgag cagattgttg caccattaga agctaggttg     60

atccacagac agatggctga aagtggaaaa gaaaaaataa aatggacaac caccattatt    120

attagctcat ctcttaagag ttatgaagtt gcaactgccc tagaaaatcg aagccacaaa    180

gttcgatatt cagattcagt ggaaaatgga tcaattatat tttctctttc tggagttgca    240

tttttattaa tggatactaa ggaatgtctt ctgtcaactg aagaaatatt tctagccaaa    300

attgagaaat ttattaacat tcaccaaaat agttttttgg ttttgtctgc tgccctccat    360

gggcctgaag aatggaaact gatgttcagg attcagcaga gattcctggg ttgtaactta    420

cgaatacttc cagtacacaa cacagtaaat gctattaatc ttatgtgcac tatagcaaag    480

actacctcca aaccatacat agatagcatt tgctacagaa tgataacagc taaagcttac    540

atcattgagc aaagtcctgt ttggaaaaca cttcagaaga taaaactgaa tagtgattca    600

gttaacccaa attagagtac caacttaatg tttttctcga agaatgtgaa aataattaga    660

cctgttaaat tataatattc aaatatctat ttaaagacat ttatattaat ttgaaataat    720

aacatataca attaaaagtg attttatttt a                                   751


<210>  274
<211>  180
<212>  PRT
<213>  Homosapiens

<400>  274

Met Ala Glu Ser Gly Lys Glu Lys Ile Lys Trp Thr Thr Thr Ile Ile 
1               5                   10                  15      


Ile Ser Ser Ser Leu Lys Ser Tyr Glu Val Ala Thr Ala Leu Glu Asn 
            20                  25                  30          


Arg Ser His Lys Val Arg Tyr Ser Asp Ser Val Glu Asn Gly Ser Ile 
        35                  40                  45              


Ile Phe Ser Leu Ser Gly Val Ala Phe Leu Leu Met Asp Thr Lys Glu 
    50                  55                  60                  


Cys Leu Leu Ser Thr Glu Glu Ile Phe Leu Ala Lys Ile Glu Lys Phe 
65                  70                  75                  80  


Ile Asn Ile His Gln Asn Ser Phe Leu Val Leu Ser Ala Ala Leu His 
                85                  90                  95      


Gly Pro Glu Glu Trp Lys Leu Met Phe Arg Ile Gln Gln Arg Phe Leu 
            100                 105                 110         


Gly Cys Asn Leu Arg Ile Leu Pro Val His Asn Thr Val Asn Ala Ile 
        115                 120                 125             


Asn Leu Met Cys Thr Ile Ala Lys Thr Thr Ser Lys Pro Tyr Ile Asp 
    130                 135                 140                 


Ser Ile Cys Tyr Arg Met Ile Thr Ala Lys Ala Tyr Ile Ile Glu Gln 
145                 150                 155                 160 


Ser Pro Val Trp Lys Thr Leu Gln Lys Ile Lys Leu Asn Ser Asp Ser 
                165                 170                 175     


Val Asn Pro Asn 
            180 


<210>  275
<211>  2042
<212>  DNA
<213>  Homosapiens

<400>  275
acgcgtagcg cggggcgggg ccagaagagc gggctaagac gccggaggag gtggcggcgg     60

ctgggagagg cgagggttct ggccgatttt agcatcgaaa ctaggagaaa taagaatggc    120

tgtagaggaa cttcagtcta taataaagag atgtcaaatc ctagaagagc aagactttaa    180

agaagaggat tttggcctat ttcagttagc tgggcaaaga tgcatagaag aagggcacac    240

agaccagcta ttagaaatta ttcaaaatga aaagaataag gtcatcatca agaatatggg    300

ctggaatctc gttggtcctg ttgttcgatg ccttttgtgt aaagataaag aggatagtaa    360

aagaaaagtt tattttttga tctttgattt attggtaaag ttatgcaatc caaaggaatt    420

attgttgggt ttgcttgaac tgattgaaga gccctctgga aaacagatat cccaaagtat    480

tcttcttttg cttcagccat tacaaacagt gattcagaaa cttcataaca aggcatattc    540

aattggatta gcattgtcta ccctttggaa tcagctatct cttcttcctg ttccatactc    600

aaaagaacaa atacaaatgg atgactatgg cctttgtcag tgttgcaagg ccttaataga    660

gttcactaag ccttttgtgg aagaagtcat tgataacaaa gaaaactcac tggaaaatga    720

aaagttaaag gatgaattac tgaaattttg tttcaaaagc ttgaaatgcc ctttgctgac    780

agcacaattc tttgaacagt ctgaagaagg tggaaatgat cctttcaggt attttgcatc    840

agaaataata ggttttttat cagcaattgg acaccctttc cccaaaatga tttttaatca    900

tggaaggaaa aagagaactt ggaattacct tgaatttgaa gaagaagaaa ataaacagtt    960

agcagactca atggcttctc tggcatatct agtatttgta cagggcatcc atattgatca   1020

gcttccaatg gtcttaagcc cattgtacct tttgcagttt aatatggggc acattgaagt   1080

ctttttgcaa agaacagaag agtctgttat ctccaaagga ttggagctgc tggagaatag   1140

tttattgaga atagaagaca atagtctact ttaccagtac ttagaaatca agagttttct   1200

tactgtacct cagggcttag tgaaagtaat gacactttgc cccattgaga cactgaggaa   1260

aaagagttta gctatgcttc agctgtatat taacaagttg gattcacaag gcaaatatac   1320

attatttagg tgcttattga atacaagtaa tcactcaggt gtggaggctt ttattattca   1380

aaatatcaaa aatcaaattg acatgtcatt aaagagaaca cgtaacaaca aatggtttac   1440

aggaccacag ttgatttccc ttcttgattt ggtacttttt ctcccagagg gtgcagaaac   1500

agatttactg caaaactcag ataggattat ggcttcatta aatttattga ggtatttggt   1560

tatcaaagat aatgaaaatg acaatcaaac tggattatgg acagaacttg gaaatattga   1620

gaataatttc ttaaagccac ttcatatagg acttaatatg tcaaaagcac attatgaagc   1680

agaaattaaa aatagccaag aggcccagaa atctaaagat ctttgttcta taactgtaag   1740

tggagaagag atccctaata tgcctcctga aatgcagctt aaggtcctgc attcagctct   1800

tttcacattt gatttgattg aaagtgttct agctcgagtg gaagaactca ttgaaataaa   1860

aacaaagtct acctctgaag aaaatattgg gataaagtga aagttccatt tcctaaataa   1920

aaactaataa aatatagtac tttccattat gattcattta atacctttat aaaaaatttt   1980

tctgtaaaaa tttactgctt gaaaaataaa tgtagctttt ctcatttatc aaaaaaaaaa   2040

aa                                                                  2042


<210>  276
<211>  594
<212>  PRT
<213>  Homosapiens

<400>  276

Met Ala Val Glu Glu Leu Gln Ser Ile Ile Lys Arg Cys Gln Ile Leu 
1               5                   10                  15      


Glu Glu Gln Asp Phe Lys Glu Glu Asp Phe Gly Leu Phe Gln Leu Ala 
            20                  25                  30          


Gly Gln Arg Cys Ile Glu Glu Gly His Thr Asp Gln Leu Leu Glu Ile 
        35                  40                  45              


Ile Gln Asn Glu Lys Asn Lys Val Ile Ile Lys Asn Met Gly Trp Asn 
    50                  55                  60                  


Leu Val Gly Pro Val Val Arg Cys Leu Leu Cys Lys Asp Lys Glu Asp 
65                  70                  75                  80  


Ser Lys Arg Lys Val Tyr Phe Leu Ile Phe Asp Leu Leu Val Lys Leu 
                85                  90                  95      


Cys Asn Pro Lys Glu Leu Leu Leu Gly Leu Leu Glu Leu Ile Glu Glu 
            100                 105                 110         


Pro Ser Gly Lys Gln Ile Ser Gln Ser Ile Leu Leu Leu Leu Gln Pro 
        115                 120                 125             


Leu Gln Thr Val Ile Gln Lys Leu His Asn Lys Ala Tyr Ser Ile Gly 
    130                 135                 140                 


Leu Ala Leu Ser Thr Leu Trp Asn Gln Leu Ser Leu Leu Pro Val Pro 
145                 150                 155                 160 


Tyr Ser Lys Glu Gln Ile Gln Met Asp Asp Tyr Gly Leu Cys Gln Cys 
                165                 170                 175     


Cys Lys Ala Leu Ile Glu Phe Thr Lys Pro Phe Val Glu Glu Val Ile 
            180                 185                 190         


Asp Asn Lys Glu Asn Ser Leu Glu Asn Glu Lys Leu Lys Asp Glu Leu 
        195                 200                 205             


Leu Lys Phe Cys Phe Lys Ser Leu Lys Cys Pro Leu Leu Thr Ala Gln 
    210                 215                 220                 


Phe Phe Glu Gln Ser Glu Glu Gly Gly Asn Asp Pro Phe Arg Tyr Phe 
225                 230                 235                 240 


Ala Ser Glu Ile Ile Gly Phe Leu Ser Ala Ile Gly His Pro Phe Pro 
                245                 250                 255     


Lys Met Ile Phe Asn His Gly Arg Lys Lys Arg Thr Trp Asn Tyr Leu 
            260                 265                 270         


Glu Phe Glu Glu Glu Glu Asn Lys Gln Leu Ala Asp Ser Met Ala Ser 
        275                 280                 285             


Leu Ala Tyr Leu Val Phe Val Gln Gly Ile His Ile Asp Gln Leu Pro 
    290                 295                 300                 


Met Val Leu Ser Pro Leu Tyr Leu Leu Gln Phe Asn Met Gly His Ile 
305                 310                 315                 320 


Glu Val Phe Leu Gln Arg Thr Glu Glu Ser Val Ile Ser Lys Gly Leu 
                325                 330                 335     


Glu Leu Leu Glu Asn Ser Leu Leu Arg Ile Glu Asp Asn Ser Leu Leu 
            340                 345                 350         


Tyr Gln Tyr Leu Glu Ile Lys Ser Phe Leu Thr Val Pro Gln Gly Leu 
        355                 360                 365             


Val Lys Val Met Thr Leu Cys Pro Ile Glu Thr Leu Arg Lys Lys Ser 
    370                 375                 380                 


Leu Ala Met Leu Gln Leu Tyr Ile Asn Lys Leu Asp Ser Gln Gly Lys 
385                 390                 395                 400 


Tyr Thr Leu Phe Arg Cys Leu Leu Asn Thr Ser Asn His Ser Gly Val 
                405                 410                 415     


Glu Ala Phe Ile Ile Gln Asn Ile Lys Asn Gln Ile Asp Met Ser Leu 
            420                 425                 430         


Lys Arg Thr Arg Asn Asn Lys Trp Phe Thr Gly Pro Gln Leu Ile Ser 
        435                 440                 445             


Leu Leu Asp Leu Val Leu Phe Leu Pro Glu Gly Ala Glu Thr Asp Leu 
    450                 455                 460                 


Leu Gln Asn Ser Asp Arg Ile Met Ala Ser Leu Asn Leu Leu Arg Tyr 
465                 470                 475                 480 


Leu Val Ile Lys Asp Asn Glu Asn Asp Asn Gln Thr Gly Leu Trp Thr 
                485                 490                 495     


Glu Leu Gly Asn Ile Glu Asn Asn Phe Leu Lys Pro Leu His Ile Gly 
            500                 505                 510         


Leu Asn Met Ser Lys Ala His Tyr Glu Ala Glu Ile Lys Asn Ser Gln 
        515                 520                 525             


Glu Ala Gln Lys Ser Lys Asp Leu Cys Ser Ile Thr Val Ser Gly Glu 
    530                 535                 540                 


Glu Ile Pro Asn Met Pro Pro Glu Met Gln Leu Lys Val Leu His Ser 
545                 550                 555                 560 


Ala Leu Phe Thr Phe Asp Leu Ile Glu Ser Val Leu Ala Arg Val Glu 
                565                 570                 575     


Glu Leu Ile Glu Ile Lys Thr Lys Ser Thr Ser Glu Glu Asn Ile Gly 
            580                 585                 590         


Ile Lys 
        


<210>  277
<211>  3026
<212>  DNA
<213>  Homosapiens

<400>  277
caccgtccgg cagactactc tcccccatgg cggacttcgc tgggccgtct tctgccggcc     60

gcaaggccgg ggctccccgc tgctctcgaa aagccgcagg tactaaacag acaagtactt    120

tgaaacaaga agatgcttct aaaaggaaag ctgaactaga agcagctgtg agaaagaaga    180

ttgaatttga gagaaaagct ctacatattg ttgaacagct tttagaggag aatattacag    240

aagagttcct aatggagtgt gggaggttca ttacacctgc tcactacagt gatgtcgtgg    300

atgaacgttc tattgtcaaa ctctgtggtt atcctttatg tcagaagaag ctgggaattg    360

taccaaaaca gaaatataaa atttctacca aaaccaataa agtctatgat attactgaaa    420

gaaagtcttt ttgcagcaat ttttgttatc aagcatctaa gttttttgaa gcacaaattc    480

ccaaaactcc agtatgggtt cgagaagaag agaggcatcc tgattttcaa ctgctaaagg    540

aagaacaaag tggccattct ggagaagaag tacagttatg cagtaaagcc attaaaacat    600

cagatatcga caatcctagc cactttgaaa agcaatatga atctagttct tctagcactc    660

acagtgatag tagcagtgac aatgagcaag actttgtttc ctccattcta ccaggaaaca    720

gaccaaattc aacaaatatt agaccacagc tgcaccaaaa aagcataatg aaaaagaaag    780

ctggtcacaa agctaactcc aaacacaaag acaaagaaca gacagtagta gatgtcactg    840

agcagttagg cgattgcaaa ttagatagtc aggagaaaga tgctacatgt gaacttcctt    900

tacagaaagt aaatactcag agttcttcaa atagcacttt gcctgaaaga ttaaaagcgt    960

cagaaaattc tgaaagtgaa tacagtaggt cagaaataac tctagtaggc ataagtaaga   1020

aaagtgcaga gcattttaag agaaaatttg ccaaatcaaa ccaagtgtct aggtcagtgt   1080

ctagttcagt gcaggtgtgt cctgaagttg gaaagagaaa cttacttaaa gttttgaagg   1140

agactttgat tgagtggaag acagaagaaa cattgaggtt tttgtatggc cagaattatg   1200

cttctgtgtg tctgaaaccc gaagcctctc tggttaaaga agaacttgat gaagatgaca   1260

taatctcaga tccagatagt catttccctg cctggaggga atctcagaac agcttggatg   1320

agtctttacc ttttaggggc tcaggtacag ccattaaacc actgccaagt tacgagaatt   1380

tgaaaaaaga aactgaaaag ttaaatctga ggatcaggga gttttgcaga ggacggtatg   1440

ttttgggtga agaaaccacc aaatcacaag actcagaaga gcatgattcc acctttccac   1500

tgatagactc aagttcccag aaccagatta gaaaacgcat cgtacttgaa aagttgagta   1560

aagtgttgcc tgggcttctg gttcctcttc agattacatt gggagatatt tacacacaac   1620

ttaaaaatct tgttcgaact ttcaggttaa caaatagaaa tattatacac aaacctgcgg   1680

aatggacttt aattgctatg gtgttgctgt cattactgac cccaattctt ggcattcaga   1740

aacattctca ggaaggtatg gtgtttacac ggtttctaga caccctcctt gaagaattac   1800

atctaaaaaa tgaagacctt gaaagtctaa ccatcatatt tagaaccagc tgtttaccag   1860

agtgatatat tccatgaaga caaaatagaa gatgaacttc tattcaccgt ttctggaatt   1920

ctagccgcca tgatggtctg gtggtgactg ataactagtt ttattccaag acataccttt   1980

acctctttaa gtttcaatct cccatctccc agtccttcag tccccaactg cagaggatga   2040

cctccccaga tagaggagaa tcattactcc aacaagaata accaagtctt tgtatcccta   2100

gtacaagaca tagtattttt attcgaaaat gaatgtttaa gtattaaatt gaaacttgaa   2160

tgaatattca agaaaatata atgatctcta ctttttctgg atgatttcca gccatcatat   2220

cagtttgcca aaaaaattga gaaagttatg attttgacct cccaacctaa actctaaatt   2280

ctaaagatca gtaagcaatt aggtcaataa atacatacaa tttaagatga agccctttgg   2340

aagtctagtc caaaacagga aaatctcaga actttctgga ctcaaggaaa tgctttaaat   2400

ggaatctgta gtttgtttgc aggagagaca atttctagaa tttagattgc ttttcaaaat   2460

gtttatcagg taggcaagtt agcagttgag gcggaacaca gacaacttgg ggagctttac   2520

tggaaggcca agaaaatact cttggacact ggaggaaatg acagctacta aagcccaatc   2580

atggaaaagg accagaaagc agcccactgg aatggggagc ttagtgggca aggaggtagg   2640

gatataattt ctcttcttgg ctccaccagt aattagctct gtggcccagt cacctaaact   2700

ttctggactt cagttcaggt tgtatggcag taggccatag aattggctac tgccatacaa   2760

tctctatggg aaaggactgc aaaaactaaa ttttatctct gtatgggcaa aggctactgt   2820

catcctgttg ttggtctggg gccactctga caattttttt taacctcatt tgattgtgta   2880

agggtctaac cacaacaaaa aatcatagtg taatagaatt aatcaagttc agcaaggtca   2940

caggctagat caatatacag aaaatcaatt gtatttttct gttcagaaaa ctccaaaaat   3000

gaaataaaga aaattgtgtt cacaat                                        3026


<210>  278
<211>  612
<212>  PRT
<213>  Homosapiens

<400>  278

Met Ala Asp Phe Ala Gly Pro Ser Ser Ala Gly Arg Lys Ala Gly Ala 
1               5                   10                  15      


Pro Arg Cys Ser Arg Lys Ala Ala Gly Thr Lys Gln Thr Ser Thr Leu 
            20                  25                  30          


Lys Gln Glu Asp Ala Ser Lys Arg Lys Ala Glu Leu Glu Ala Ala Val 
        35                  40                  45              


Arg Lys Lys Ile Glu Phe Glu Arg Lys Ala Leu His Ile Val Glu Gln 
    50                  55                  60                  


Leu Leu Glu Glu Asn Ile Thr Glu Glu Phe Leu Met Glu Cys Gly Arg 
65                  70                  75                  80  


Phe Ile Thr Pro Ala His Tyr Ser Asp Val Val Asp Glu Arg Ser Ile 
                85                  90                  95      


Val Lys Leu Cys Gly Tyr Pro Leu Cys Gln Lys Lys Leu Gly Ile Val 
            100                 105                 110         


Pro Lys Gln Lys Tyr Lys Ile Ser Thr Lys Thr Asn Lys Val Tyr Asp 
        115                 120                 125             


Ile Thr Glu Arg Lys Ser Phe Cys Ser Asn Phe Cys Tyr Gln Ala Ser 
    130                 135                 140                 


Lys Phe Phe Glu Ala Gln Ile Pro Lys Thr Pro Val Trp Val Arg Glu 
145                 150                 155                 160 


Glu Glu Arg His Pro Asp Phe Gln Leu Leu Lys Glu Glu Gln Ser Gly 
                165                 170                 175     


His Ser Gly Glu Glu Val Gln Leu Cys Ser Lys Ala Ile Lys Thr Ser 
            180                 185                 190         


Asp Ile Asp Asn Pro Ser His Phe Glu Lys Gln Tyr Glu Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr His Ser Asp Ser Ser Ser Asp Asn Glu Gln Asp Phe Val 
    210                 215                 220                 


Ser Ser Ile Leu Pro Gly Asn Arg Pro Asn Ser Thr Asn Ile Arg Pro 
225                 230                 235                 240 


Gln Leu His Gln Lys Ser Ile Met Lys Lys Lys Ala Gly His Lys Ala 
                245                 250                 255     


Asn Ser Lys His Lys Asp Lys Glu Gln Thr Val Val Asp Val Thr Glu 
            260                 265                 270         


Gln Leu Gly Asp Cys Lys Leu Asp Ser Gln Glu Lys Asp Ala Thr Cys 
        275                 280                 285             


Glu Leu Pro Leu Gln Lys Val Asn Thr Gln Ser Ser Ser Asn Ser Thr 
    290                 295                 300                 


Leu Pro Glu Arg Leu Lys Ala Ser Glu Asn Ser Glu Ser Glu Tyr Ser 
305                 310                 315                 320 


Arg Ser Glu Ile Thr Leu Val Gly Ile Ser Lys Lys Ser Ala Glu His 
                325                 330                 335     


Phe Lys Arg Lys Phe Ala Lys Ser Asn Gln Val Ser Arg Ser Val Ser 
            340                 345                 350         


Ser Ser Val Gln Val Cys Pro Glu Val Gly Lys Arg Asn Leu Leu Lys 
        355                 360                 365             


Val Leu Lys Glu Thr Leu Ile Glu Trp Lys Thr Glu Glu Thr Leu Arg 
    370                 375                 380                 


Phe Leu Tyr Gly Gln Asn Tyr Ala Ser Val Cys Leu Lys Pro Glu Ala 
385                 390                 395                 400 


Ser Leu Val Lys Glu Glu Leu Asp Glu Asp Asp Ile Ile Ser Asp Pro 
                405                 410                 415     


Asp Ser His Phe Pro Ala Trp Arg Glu Ser Gln Asn Ser Leu Asp Glu 
            420                 425                 430         


Ser Leu Pro Phe Arg Gly Ser Gly Thr Ala Ile Lys Pro Leu Pro Ser 
        435                 440                 445             


Tyr Glu Asn Leu Lys Lys Glu Thr Glu Lys Leu Asn Leu Arg Ile Arg 
    450                 455                 460                 


Glu Phe Cys Arg Gly Arg Tyr Val Leu Gly Glu Glu Thr Thr Lys Ser 
465                 470                 475                 480 


Gln Asp Ser Glu Glu His Asp Ser Thr Phe Pro Leu Ile Asp Ser Ser 
                485                 490                 495     


Ser Gln Asn Gln Ile Arg Lys Arg Ile Val Leu Glu Lys Leu Ser Lys 
            500                 505                 510         


Val Leu Pro Gly Leu Leu Val Pro Leu Gln Ile Thr Leu Gly Asp Ile 
        515                 520                 525             


Tyr Thr Gln Leu Lys Asn Leu Val Arg Thr Phe Arg Leu Thr Asn Arg 
    530                 535                 540                 


Asn Ile Ile His Lys Pro Ala Glu Trp Thr Leu Ile Ala Met Val Leu 
545                 550                 555                 560 


Leu Ser Leu Leu Thr Pro Ile Leu Gly Ile Gln Lys His Ser Gln Glu 
                565                 570                 575     


Gly Met Val Phe Thr Arg Phe Leu Asp Thr Leu Leu Glu Glu Leu His 
            580                 585                 590         


Leu Lys Asn Glu Asp Leu Glu Ser Leu Thr Ile Ile Phe Arg Thr Ser 
        595                 600                 605             


Cys Leu Pro Glu 
    610         


<210>  279
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  279
cttttggtga acaaggttca catttattgc caaaagatgt ctactctcct ggaaaacatc     60

tttgccataa ttaatctttt caagcaatat tcaaaaaaag ataaaaacac tgacacattg    120

agtaaaaaag agctgaagga acttctggaa aaggaatttc ggcaaatcct gaagaatcca    180

gatgacccag atatggttga tgtcttcatg gatcacttgg atatagacca caacaagaaa    240

attgacttca ctgagtttct tctgatggta ttcaagttgg ctcaagcata ttatgagtct    300

accagaaaag agaatttacc gatatcagga cacaagcaca gaaagcacag tcatcatgat    360

aaacatgaag ataataaaca ggaagaaaac aaagaaaaca gaaaaagacc ctcaagtctg    420

gaaagaagaa acaatagaaa agggaataag ggaagatcca agagcccaag agaaacaggg    480

gggaaaaggc atgaatctag ttctgaaaaa aaagaaagaa aaggatattc acctactcat    540

agagaagaag aatatggaaa aaaccatcat aactcaagta aaaaagagaa aaacaagact    600

gaaaatacta gattaggaga caataggaag aggctaagtg aaagacttga agagaaagaa    660

gacaatgaag aaggagtata tgattatgaa aatacaggaa gaatgactca aaaatggata    720

caatcaggcc atattgccac atattacaca atccaggatg aagcctatga caccactgat    780

agtctattag aagaaaacaa aatatatgaa agatcaaggt catctgatgg caaatcatca    840

tctcaagtga acaggtcaag acatgaaaat acaagccagg taccattgca ggagtccagg    900

acaagaaagc gtaggggatc cagagttagc caggacaggg acagtgaggg acactcagaa    960

gactctgaga ggcactctgg gtcggcttcc agaaaccatc atggatctgc gtgggagcag   1020

tcaagagatg gctccagaca ccccaggtcc catgatgaag acagagccag tcatgggcac   1080

tctgcagaca gctccagaca atcaggcact cgtcacgcag agacttcctc tcgtggacag   1140

actgcatcat cccatgaaca ggcaagatca agtccaggag aaagacatgg atccggccac   1200

cagcagtcag cagacagctc cagacactca gccactgggc gcgggcaagc ttcatctgca   1260

gtcagcgatc gtggacaccg ggggtctagc ggtagtcagg ccagtgacag tgagggacat   1320

tcagaaaact cagacacaca atcagtgtca ggccacggaa aggctgggct gagacagcag   1380

agccaccaag agtccacacg tggccggtca ggggaacggt ctggacgttc agggtcttcc   1440

ctctaccagg tgagcactca tgaacagcct gactctgccc atggacggac cgggaccagc   1500

actggaggaa gacaaggatc gcaccacgag caggcacgag acagctccag gcattcagcg   1560

tcccaagagg gtcaggacac cattcgtgga cacccggggt caagcagagg aggaaggcag   1620

ggatcccacc acgagcaatc ggtaaatagg tctggacact caggttccca tcacagccac   1680

accacatccc agggaaggtc tgatgcctcc catgggcagt caggatccag aagtgcaagc   1740

agacaaacac gaaatgagga acaatcagga gacggcacca ggcactcagg gtcacgtcat   1800

catgaagctt cctctcaggc tgacagctct agacactcac aggtgggcca gggacaatca   1860

tcggggccca ggacaagtag gaaccaggga tccagtgtta gccaggacag tgacagtcag   1920

ggacactcag aagactctga gaggtggtct gggtctgctt ccagaaacca tcatggatct   1980

gctcaggagc agtcaagaga tggctccaga caccccaggt cccatcacga agacagagct   2040

ggtcatgggc actctgcaga cagctccaga aaatcaggca ctcgtcacac acagaattcc   2100

tctagtggac aggctgcgtc atcccatgaa caggcaagat caagtgcagg agaaagacat   2160

ggatcccgcc accagctcca gtcagcagac agctccagac actcaggcac tgggcacgga   2220

caagcttcat ctgcagtcag agacagtgga caccgagggt ccagtggtag tcaggccact   2280

gacagtgagg gacattcaga agactcagac acacagtcag tgtcaggcca tggacaggct   2340

ggtcaccatc agcagagcca ccaagagtcc gcacgtgacc ggtcagggga aaggtctcga   2400

cgttcagggt ctttcctcta ccaggtgagc actcataaac agtctgagtc ctcccatgga   2460

tggacagggc ccagcactgg agtaagacaa ggatcccacc atgagcaggc acgagacaac   2520

tccaggcact cagcatccca agatggtcag gacaccattc gtggacaccc ggggtcaagc   2580

agaagaggaa ggcaggggtc ccaccacgag caatcggtag ataggtctgg acactcaggg   2640

tcccatcaca gccacaccac atcccaggga aggtctgatg cctcccgtgg gcagtcagga   2700

tccagaagtg caagcagaac aacacgtaat gaggaacaat caagagacgg ctccaggcac   2760

tcagggtcac gtcaccatga agcttcctct catgccgaca tctctagaca ctcacaggca   2820

ggccagggac aatcagaggg gtccaggaca agcaggcgcc agggatccag tgttagccag   2880

gacagtgaca gtgagggaca ttcagaagac tctgagaggt ggtctgggtc tgcttccaga   2940

aaccatcgtg gatctgctca ggagcagtca agacatggct ccagacaccc caggtcccat   3000

cacgaagaca gagccggtca cgggcactct gcagacagct ccagacaatc aggaactcct   3060

cacgcagaga cttcctctgg tggacaggct gcgtcatccc atgaacaggc aagatcaagt   3120

ccaggagaaa gacacggatc ccgccaccag cagtcagcag acagctccag acactcaggc   3180

attccgcgca gacaagcttc atctgcagtc agagacagtg gacactgggg gtccagtggt   3240

agtcaggcca gtgatagtga gggacattca gaggagtcag acacacagtc agtgtcaggc   3300

catggacagg atgggcccca tcagcagagc caccaagagt ccgcacgtga ctggtcaggg   3360

ggaaggtctg gacgttcagg gtctttcatc taccaggtga gcactcatga acagtctgag   3420

tctgcccatg ggcggaccag gaccagcact ggacgaagac aaggatccca ccacgagcag   3480

gcacgagaca gctccaggca ctcagcgtcc caagagggtc aggacaccat tcgtgcacac   3540

ccggggtcaa ggagaggagg aaggcaggga tcccaccatg agcaatcggt agatagatct   3600

ggacactcag ggtcccatca cagccacacc acatcccagg gaaggtctga tgcctcccat   3660

gggcagtcag gatccagaag tgcaagcaga caaactcgta aggacaaaca atcaggagac   3720

ggctccaggc actcagggtc acgtcaccat gaagctgcct cttgggctga cagctctaga   3780

cactcacagg tgggacagga acaatcatcg gggtccagga caagcaggca ccagggatcc   3840

agtgttagcc aggacagtga cagtgagaga cactcagacg actccgagag gttgtctggg   3900

tctgcttcca gaaaccatca tggatcttct cgggagcagt caagagatgg ctccagacac   3960

cctgggttcc atcaagaaga cagagccagt cacgggcact ctgcagacag ctccagacaa   4020

tcaggcactc atcacacaga gtcttcctct catggacagg ctgtgtcatc ccatgaacag   4080

gcaagatcaa gtccaggaga aagacatgga tcccgccacc agcagtcagc agacagctcc   4140

agacactcag gcattgggca cagacaagct tcatctgcag tcagagacag tggacaccga   4200

gggtccagtg gtagtcaggt cactaacagt gagggacatt cagaagactc agacacacag   4260

tcagtgtcag cccacggaca agctgggccc catcagcaga gccacaaaga gtccgcacgt   4320

ggccagtcag gggaaagctc tggacgttca aggtctttcc tctaccaggt gagctctcat   4380

gaacagtctg agtccacaca cggacagact gcacccagca ctggaggaag acaaggatcc   4440

cgccatgagc aggcacgaaa cagctctagg cactcagcat cccaagacgg tcaggacacc   4500

attcgtggac acccggggtc aagcagagga ggaaggcagg gatcctacca cgagcaatca   4560

gtagataggt ctggacactc agggtaccat cacagccaca ccacacccca gggaaggtct   4620

gatgcctccc atgggcagtc aggacccaga agtgcaagca ggcaaacaag aaatgaggaa   4680

caatcaggag acggctccag gcactcaggg tcacgtcacc atgaaccttc cactcgggcc   4740

ggcagctcta gacactcaca ggtgggccag ggagaatcag cggggtccaa gacaagcagg   4800

cgccagggat ccagtgttag tcaggacagg gacagtgagg gacactcaga agactctgag   4860

aggcggtctg agtcggcttc cagaaaccat tatggatctg ctcgggagca gtcaagacat   4920

ggctccagga accccaggtc ccatcaagaa gatagagcca gtcatgggca ctctgcagag   4980

agctccagac aatcaggcac tcgtcatgca gagacttcct ctggtggaca ggctgcatca   5040

tcccaggaac aggcaaggtc aagtccagga gaaagacatg gatcccgcca ccagcagtca   5100

gcagacagct ccacagactc aggcactggg cgcagacaag attcatctgt agtcggagac   5160

agtggaaacc gagggtccag tggtagccag gccagtgaca gcgagggaca ctcagaagag   5220

tcagacacac agtcagtgtc agcccacgga caggctgggc cccatcagca gagccaccaa   5280

gagtccacac gtggccagtc aggggaaagg tctggacgtt cagggtcttt cctctaccag   5340

gtgagcactc atgaacagtc tgagtccgcc catggacgca cagggcccag cactggagga   5400

agacaaagat cccgccacga gcaggcacga gacagctcca ggcactcagc gtcccaagag   5460

ggtcaggaca ccattcgtgg acacccaggg tcaagcagag gaggaaggca gggatcccac   5520

tatgagcaat cggtagatag ttctggacac tcagggtctc atcacagcca caccacgtcc   5580

caggaaaggt ctgatgtctc ccgtgggcag tcaggatcca gaagtgtcag cagacaaaca   5640

cgtaatgaga aacaatcagg agacggctcc aggcactcag ggtcgcgtca ccatgaagct   5700

tcctctcggg ccgacagctc tagacactcg caggtgggcc agggacaatc atcagggccc   5760

aggacaagca ggaaccaggg atccagtgtt agccaggaca gtgacagtca gggacactca   5820

gaagactctg agaggtggtc tgggtctgct tccagaaacc atcttggatc tgcttgggag   5880

cagtcaagag atggctccag acaccctggg tcccatcacg aagacagagc cggtcacggg   5940

cactctgcag acagctccag acaatcaggc actcgtcaca cagagtcttc ctctcgtgga   6000

caggctgcgt catcccatga acaggcaaga tcaagtgcag gagaaagaca tggatcccac   6060

caccagctcc agtcagcaga cagctccaga cactcaggca ttgggcatgg acaagcttca   6120

tctgcagtca gagacagtgg acaccgaggg tacagtggta gtcaggccag tgacagtgag   6180

ggacattcag aagactcaga cacacagtca gtgtcagcac agggaaaagc tgggccccat   6240

cagcagagcc acaaagagtc cgcacgtggc cagtcagggg aaagctctgg acgttcaggg   6300

tctttcctct accaggtgag cactcatgaa cagtctgagt ccacccatgg acagtctgcg   6360

cccagcactg gaggaagaca aggatcccat tatgatcagg cacaagacag ctccaggcac   6420

tcagcatccc aagagggtca ggacaccatt cgtggacacc cggggccaag cagaggagga   6480

agacaggggt cccaccaaga gcaatcggta gataggtctg gacactcagg gtctcatcac   6540

agccacacca catcccaggg aaggtctgat gcctcccgtg ggcagtcagg atccagaagt   6600

gcaagcagaa aaacatatga caaggaacaa tcaggagatg gctctaggca ctcagggtcg   6660

catcatcatg aagcttcctc ttgggccgac agctctagac actcactggt gggccaggga   6720

caatcatcag ggcccaggac aagcaggccc cggggatcca gtgttagcca ggacagtgac   6780

agtgagggac actcagaaga ttctgagagg cggtctgggt ctgcgtccag aaaccatcat   6840

ggatctgctc aggagcagtc aagagatggc tccagacacc ccaggtccca tcacgaagac   6900

agagccggtc atgggcactc tgcagagagc tccagacaat caggcactca tcatgcagag   6960

aattcctctg gtggacaggc tgcatcatcc catgaacagg caagatcaag tgcaggagag   7020

agacacggat cccaccacca gcagtcagca gacagctcca gacactcagg cattgggcac   7080

ggacaagctt catctgcagt cagagacagt ggacaccgag ggtccagtgg tagtcaggcc   7140

agtgacagtg agggacattc agaagactca gacacacagt cagtgtcagc ccacggacag   7200

gctgggcccc atcagcagag ccaccaagag tccacacgtg gccggtcagc aggaaggtct   7260

ggacgttcag ggtctttcct ctaccaggtg agcactcatg aacagtctga gtccgcccat   7320

ggacggaccg ggaccagcac tggaggaaga caaggatccc accacaagca ggcacgagac   7380

agctccaggc actcaacgtc ccaagagggt caggacacca ttcatggaca cccggggtca   7440

agcagtggag gaaggcaggg atcccactac gagcaattgg tagatagatc tggacactca   7500

gggtctcatc acagccacac cacatcccag ggaaggtctg atgcctccca tgggcactca   7560

ggatccagaa gtgcaagcag acaaactcgt aacgatgaac aatcaggaga cggctccagg   7620

cactcagggt cgcgtcacca tgaagcttcc tctcgggccg acagctctgg acactcgcag   7680

gtgggccagg gacaatcaga ggggcccagg acaagcagga actggggatc cagttttagc   7740

caggacagtg acagtcaggg acactcagaa gactctgaga ggtggtctgg gtctgcttcc   7800

agaaaccatc atggatctgc tcaggagcag ctaagagatg gctccagaca ccccaggtcc   7860

catcaagaag acagagctgg tcatgggcac tctgcagaca gctccagaca atcaggcact   7920

cgtcacacac agacttcctc tggtggacag gctgcatcat cccatgaaca ggcaagatca   7980

agtgcaggag aaagacatgg atcccaccac cagcagtcag cagacagctc cagacactca   8040

ggcattgggc acggacaagc ttcatctgca gtcagagaca gtggacaccg agggtacagt   8100

ggtagtcagg ccagtgacaa tgagggacat tcagaagact cagacacaca gtcagtgtca   8160

gcccacggac aggctgggtc ccatcagcag ag                                 8192


<210>  280
<211>  4061
<212>  PRT
<213>  Homosapiens

<400>  280

Met Ser Thr Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys 
1               5                   10                  15      


Gln Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp 
    50                  55                  60                  


His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile 
                85                  90                  95      


Ser Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp 
            100                 105                 110         


Asn Lys Gln Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu 
        115                 120                 125             


Glu Arg Arg Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro 
    130                 135                 140                 


Arg Glu Thr Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu 
145                 150                 155                 160 


Arg Lys Gly Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn 
                165                 170                 175     


His His Asn Ser Ser Lys Lys Glu Lys Asn Lys Thr Glu Asn Thr Arg 
            180                 185                 190         


Leu Gly Asp Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu 
        195                 200                 205             


Asp Asn Glu Glu Gly Val Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr 
    210                 215                 220                 


Gln Lys Trp Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln 
225                 230                 235                 240 


Asp Glu Ala Tyr Asp Thr Thr Asp Ser Leu Leu Glu Glu Asn Lys Ile 
                245                 250                 255     


Tyr Glu Arg Ser Arg Ser Ser Asp Gly Lys Ser Ser Ser Gln Val Asn 
            260                 265                 270         


Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg 
        275                 280                 285             


Thr Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu 
    290                 295                 300                 


Gly His Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn 
305                 310                 315                 320 


His His Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro 
                325                 330                 335     


Arg Ser His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser 
            340                 345                 350         


Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln 
        355                 360                 365             


Thr Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His 
    370                 375                 380                 


Gly Ser Gly His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr 
385                 390                 395                 400 


Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg Gly His Arg Gly 
                405                 410                 415     


Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asn Ser 
            420                 425                 430         


Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly Leu Arg Gln Gln 
        435                 440                 445             


Ser His Gln Glu Ser Thr Arg Gly Arg Ser Gly Glu Arg Ser Gly Arg 
    450                 455                 460                 


Ser Gly Ser Ser Leu Tyr Gln Val Ser Thr His Glu Gln Pro Asp Ser 
465                 470                 475                 480 


Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His 
                485                 490                 495     


His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly 
            500                 505                 510         


Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln 
        515                 520                 525             


Gly Ser His His Glu Gln Ser Val Asn Arg Ser Gly His Ser Gly Ser 
    530                 535                 540                 


His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly 
545                 550                 555                 560 


Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu Glu Gln 
                565                 570                 575     


Ser Gly Asp Gly Thr Arg His Ser Gly Ser Arg His His Glu Ala Ser 
            580                 585                 590         


Ser Gln Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser 
        595                 600                 605             


Ser Gly Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp 
    610                 615                 620                 


Ser Asp Ser Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser 
625                 630                 635                 640 


Ala Ser Arg Asn His His Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly 
                645                 650                 655     


Ser Arg His Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His 
            660                 665                 670         


Ser Ala Asp Ser Ser Arg Lys Ser Gly Thr Arg His Thr Gln Asn Ser 
        675                 680                 685             


Ser Ser Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala 
    690                 695                 700                 


Gly Glu Arg His Gly Ser Arg His Gln Leu Gln Ser Ala Asp Ser Ser 
705                 710                 715                 720 


Arg His Ser Gly Thr Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp 
                725                 730                 735     


Ser Gly His Arg Gly Ser Ser Gly Ser Gln Ala Thr Asp Ser Glu Gly 
            740                 745                 750         


His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala 
        755                 760                 765             


Gly His His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly 
    770                 775                 780                 


Glu Arg Ser Arg Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His 
785                 790                 795                 800 


Lys Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Gly Val 
                805                 810                 815     


Arg Gln Gly Ser His His Glu Gln Ala Arg Asp Asn Ser Arg His Ser 
            820                 825                 830         


Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser 
        835                 840                 845             


Arg Arg Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser 
    850                 855                 860                 


Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser 
865                 870                 875                 880 


Asp Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr 
                885                 890                 895     


Arg Asn Glu Glu Gln Ser Arg Asp Gly Ser Arg His Ser Gly Ser Arg 
            900                 905                 910         


His His Glu Ala Ser Ser His Ala Asp Ile Ser Arg His Ser Gln Ala 
        915                 920                 925             


Gly Gln Gly Gln Ser Glu Gly Ser Arg Thr Ser Arg Arg Gln Gly Ser 
    930                 935                 940                 


Ser Val Ser Gln Asp Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu 
945                 950                 955                 960 


Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg Gly Ser Ala Gln Glu 
                965                 970                 975     


Gln Ser Arg His Gly Ser Arg His Pro Arg Ser His His Glu Asp Arg 
            980                 985                 990         


Ala Gly His Gly His Ser Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Pro 
        995                 1000                 1005             


His Ala  Glu Thr Ser Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu 
    1010                 1015                 1020             


Gln Ala  Arg Ser Ser Pro Gly  Glu Arg His Gly Ser  Arg His Gln 
    1025                 1030                 1035             


Gln Ser  Ala Asp Ser Ser Arg  His Ser Gly Ile Pro  Arg Arg Gln 
    1040                 1045                 1050             


Ala Ser  Ser Ala Val Arg Asp  Ser Gly His Trp Gly  Ser Ser Gly 
    1055                 1060                 1065             


Ser Gln  Ala Ser Asp Ser Glu  Gly His Ser Glu Glu  Ser Asp Thr 
    1070                 1075                 1080             


Gln Ser  Val Ser Gly His Gly  Gln Asp Gly Pro His  Gln Gln Ser 
    1085                 1090                 1095             


His Gln  Glu Ser Ala Arg Asp  Trp Ser Gly Gly Arg  Ser Gly Arg 
    1100                 1105                 1110             


Ser Gly  Ser Phe Ile Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu 
    1115                 1120                 1125             


Ser Ala  His Gly Arg Thr Arg  Thr Ser Thr Gly Arg  Arg Gln Gly 
    1130                 1135                 1140             


Ser His  His Glu Gln Ala Arg  Asp Ser Ser Arg His  Ser Ala Ser 
    1145                 1150                 1155             


Gln Glu  Gly Gln Asp Thr Ile  Arg Ala His Pro Gly  Ser Arg Arg 
    1160                 1165                 1170             


Gly Gly  Arg Gln Gly Ser His  His Glu Gln Ser Val  Asp Arg Ser 
    1175                 1180                 1185             


Gly His  Ser Gly Ser His His  Ser His Thr Thr Ser  Gln Gly Arg 
    1190                 1195                 1200             


Ser Asp  Ala Ser His Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg 
    1205                 1210                 1215             


Gln Thr  Arg Lys Asp Lys Gln  Ser Gly Asp Gly Ser  Arg His Ser 
    1220                 1225                 1230             


Gly Ser  Arg His His Glu Ala  Ala Ser Trp Ala Asp  Ser Ser Arg 
    1235                 1240                 1245             


His Ser  Gln Val Gly Gln Glu  Gln Ser Ser Gly Ser  Arg Thr Ser 
    1250                 1255                 1260             


Arg His  Gln Gly Ser Ser Val  Ser Gln Asp Ser Asp  Ser Glu Arg 
    1265                 1270                 1275             


His Ser  Asp Asp Ser Glu Arg  Leu Ser Gly Ser Ala  Ser Arg Asn 
    1280                 1285                 1290             


His His  Gly Ser Ser Arg Glu  Gln Ser Arg Asp Gly  Ser Arg His 
    1295                 1300                 1305             


Pro Gly  Phe His Gln Glu Asp  Arg Ala Ser His Gly  His Ser Ala 
    1310                 1315                 1320             


Asp Ser  Ser Arg Gln Ser Gly  Thr His His Thr Glu  Ser Ser Ser 
    1325                 1330                 1335             


His Gly  Gln Ala Val Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro 
    1340                 1345                 1350             


Gly Glu  Arg His Gly Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser 
    1355                 1360                 1365             


Arg His  Ser Gly Ile Gly His  Arg Gln Ala Ser Ser  Ala Val Arg 
    1370                 1375                 1380             


Asp Ser  Gly His Arg Gly Ser  Ser Gly Ser Gln Val  Thr Asn Ser 
    1385                 1390                 1395             


Glu Gly  His Ser Glu Asp Ser  Asp Thr Gln Ser Val  Ser Ala His 
    1400                 1405                 1410             


Gly Gln  Ala Gly Pro His Gln  Gln Ser His Lys Glu  Ser Ala Arg 
    1415                 1420                 1425             


Gly Gln  Ser Gly Glu Ser Ser  Gly Arg Ser Arg Ser  Phe Leu Tyr 
    1430                 1435                 1440             


Gln Val  Ser Ser His Glu Gln  Ser Glu Ser Thr His  Gly Gln Thr 
    1445                 1450                 1455             


Ala Pro  Ser Thr Gly Gly Arg  Gln Gly Ser Arg His  Glu Gln Ala 
    1460                 1465                 1470             


Arg Asn  Ser Ser Arg His Ser  Ala Ser Gln Asp Gly  Gln Asp Thr 
    1475                 1480                 1485             


Ile Arg  Gly His Pro Gly Ser  Ser Arg Gly Gly Arg  Gln Gly Ser 
    1490                 1495                 1500             


Tyr His  Glu Gln Ser Val Asp  Arg Ser Gly His Ser  Gly Tyr His 
    1505                 1510                 1515             


His Ser  His Thr Thr Pro Gln  Gly Arg Ser Asp Ala  Ser His Gly 
    1520                 1525                 1530             


Gln Ser  Gly Pro Arg Ser Ala  Ser Arg Gln Thr Arg  Asn Glu Glu 
    1535                 1540                 1545             


Gln Ser  Gly Asp Gly Ser Arg  His Ser Gly Ser Arg  His His Glu 
    1550                 1555                 1560             


Pro Ser  Thr Arg Ala Gly Ser  Ser Arg His Ser Gln  Val Gly Gln 
    1565                 1570                 1575             


Gly Glu  Ser Ala Gly Ser Lys  Thr Ser Arg Arg Gln  Gly Ser Ser 
    1580                 1585                 1590             


Val Ser  Gln Asp Arg Asp Ser  Glu Gly His Ser Glu  Asp Ser Glu 
    1595                 1600                 1605             


Arg Arg  Ser Glu Ser Ala Ser  Arg Asn His Tyr Gly  Ser Ala Arg 
    1610                 1615                 1620             


Glu Gln  Ser Arg His Gly Ser  Arg Asn Pro Arg Ser  His Gln Glu 
    1625                 1630                 1635             


Asp Arg  Ala Ser His Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser 
    1640                 1645                 1650             


Gly Thr  Arg His Ala Glu Thr  Ser Ser Gly Gly Gln  Ala Ala Ser 
    1655                 1660                 1665             


Ser Gln  Glu Gln Ala Arg Ser  Ser Pro Gly Glu Arg  His Gly Ser 
    1670                 1675                 1680             


Arg His  Gln Gln Ser Ala Asp  Ser Ser Thr Asp Ser  Gly Thr Gly 
    1685                 1690                 1695             


Arg Arg  Gln Asp Ser Ser Val  Val Gly Asp Ser Gly  Asn Arg Gly 
    1700                 1705                 1710             


Ser Ser  Gly Ser Gln Ala Ser  Asp Ser Glu Gly His  Ser Glu Glu 
    1715                 1720                 1725             


Ser Asp  Thr Gln Ser Val Ser  Ala His Gly Gln Ala  Gly Pro His 
    1730                 1735                 1740             


Gln Gln  Ser His Gln Glu Ser  Thr Arg Gly Gln Ser  Gly Glu Arg 
    1745                 1750                 1755             


Ser Gly  Arg Ser Gly Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu 
    1760                 1765                 1770             


Gln Ser  Glu Ser Ala His Gly  Arg Thr Gly Pro Ser  Thr Gly Gly 
    1775                 1780                 1785             


Arg Gln  Arg Ser Arg His Glu  Gln Ala Arg Asp Ser  Ser Arg His 
    1790                 1795                 1800             


Ser Ala  Ser Gln Glu Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly 
    1805                 1810                 1815             


Ser Ser  Arg Gly Gly Arg Gln  Gly Ser His Tyr Glu  Gln Ser Val 
    1820                 1825                 1830             


Asp Ser  Ser Gly His Ser Gly  Ser His His Ser His  Thr Thr Ser 
    1835                 1840                 1845             


Gln Glu  Arg Ser Asp Val Ser  Arg Gly Gln Ser Gly  Ser Arg Ser 
    1850                 1855                 1860             


Val Ser  Arg Gln Thr Arg Asn  Glu Lys Gln Ser Gly  Asp Gly Ser 
    1865                 1870                 1875             


Arg His  Ser Gly Ser Arg His  His Glu Ala Ser Ser  Arg Ala Asp 
    1880                 1885                 1890             


Ser Ser  Arg His Ser Gln Val  Gly Gln Gly Gln Ser  Ser Gly Pro 
    1895                 1900                 1905             


Arg Thr  Ser Arg Asn Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp 
    1910                 1915                 1920             


Ser Gln  Gly His Ser Glu Asp  Ser Glu Arg Trp Ser  Gly Ser Ala 
    1925                 1930                 1935             


Ser Arg  Asn His Leu Gly Ser  Ala Trp Glu Gln Ser  Arg Asp Gly 
    1940                 1945                 1950             


Ser Arg  His Pro Gly Ser His  His Glu Asp Arg Ala  Gly His Gly 
    1955                 1960                 1965             


His Ser  Ala Asp Ser Ser Arg  Gln Ser Gly Thr Arg  His Thr Glu 
    1970                 1975                 1980             


Ser Ser  Ser Arg Gly Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg 
    1985                 1990                 1995             


Ser Ser  Ala Gly Glu Arg His  Gly Ser His His Gln  Leu Gln Ser 
    2000                 2005                 2010             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    2015                 2020                 2025             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Tyr Ser  Gly Ser Gln 
    2030                 2035                 2040             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    2045                 2050                 2055             


Val Ser  Ala Gln Gly Lys Ala  Gly Pro His Gln Gln  Ser His Lys 
    2060                 2065                 2070             


Glu Ser  Ala Arg Gly Gln Ser  Gly Glu Ser Ser Gly  Arg Ser Gly 
    2075                 2080                 2085             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Thr 
    2090                 2095                 2100             


His Gly  Gln Ser Ala Pro Ser  Thr Gly Gly Arg Gln  Gly Ser His 
    2105                 2110                 2115             


Tyr Asp  Gln Ala Gln Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    2120                 2125                 2130             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Pro Ser  Arg Gly Gly 
    2135                 2140                 2145             


Arg Gln  Gly Ser His Gln Glu  Gln Ser Val Asp Arg  Ser Gly His 
    2150                 2155                 2160             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    2165                 2170                 2175             


Ala Ser  Arg Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Lys Thr 
    2180                 2185                 2190             


Tyr Asp  Lys Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    2195                 2200                 2205             


His His  His Glu Ala Ser Ser  Trp Ala Asp Ser Ser  Arg His Ser 
    2210                 2215                 2220             


Leu Val  Gly Gln Gly Gln Ser  Ser Gly Pro Arg Thr  Ser Arg Pro 
    2225                 2230                 2235             


Arg Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Gly His Ser 
    2240                 2245                 2250             


Glu Asp  Ser Glu Arg Arg Ser  Gly Ser Ala Ser Arg  Asn His His 
    2255                 2260                 2265             


Gly Ser  Ala Gln Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Arg 
    2270                 2275                 2280             


Ser His  His Glu Asp Arg Ala  Gly His Gly His Ser  Ala Glu Ser 
    2285                 2290                 2295             


Ser Arg  Gln Ser Gly Thr His  His Ala Glu Asn Ser  Ser Gly Gly 
    2300                 2305                 2310             


Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg Ser Ser  Ala Gly Glu 
    2315                 2320                 2325             


Arg His  Gly Ser His His Gln  Gln Ser Ala Asp Ser  Ser Arg His 
    2330                 2335                 2340             


Ser Gly  Ile Gly His Gly Gln  Ala Ser Ser Ala Val  Arg Asp Ser 
    2345                 2350                 2355             


Gly His  Arg Gly Ser Ser Gly  Ser Gln Ala Ser Asp  Ser Glu Gly 
    2360                 2365                 2370             


His Ser  Glu Asp Ser Asp Thr  Gln Ser Val Ser Ala  His Gly Gln 
    2375                 2380                 2385             


Ala Gly  Pro His Gln Gln Ser  His Gln Glu Ser Thr  Arg Gly Arg 
    2390                 2395                 2400             


Ser Ala  Gly Arg Ser Gly Arg  Ser Gly Ser Phe Leu  Tyr Gln Val 
    2405                 2410                 2415             


Ser Thr  His Glu Gln Ser Glu  Ser Ala His Gly Arg  Thr Gly Thr 
    2420                 2425                 2430             


Ser Thr  Gly Gly Arg Gln Gly  Ser His His Lys Gln  Ala Arg Asp 
    2435                 2440                 2445             


Ser Ser  Arg His Ser Thr Ser  Gln Glu Gly Gln Asp  Thr Ile His 
    2450                 2455                 2460             


Gly His  Pro Gly Ser Ser Ser  Gly Gly Arg Gln Gly  Ser His Tyr 
    2465                 2470                 2475             


Glu Gln  Leu Val Asp Arg Ser  Gly His Ser Gly Ser  His His Ser 
    2480                 2485                 2490             


His Thr  Thr Ser Gln Gly Arg  Ser Asp Ala Ser His  Gly His Ser 
    2495                 2500                 2505             


Gly Ser  Arg Ser Ala Ser Arg  Gln Thr Arg Asn Asp  Glu Gln Ser 
    2510                 2515                 2520             


Gly Asp  Gly Ser Arg His Ser  Gly Ser Arg His His  Glu Ala Ser 
    2525                 2530                 2535             


Ser Arg  Ala Asp Ser Ser Gly  His Ser Gln Val Gly  Gln Gly Gln 
    2540                 2545                 2550             


Ser Glu  Gly Pro Arg Thr Ser  Arg Asn Trp Gly Ser  Ser Phe Ser 
    2555                 2560                 2565             


Gln Asp  Ser Asp Ser Gln Gly  His Ser Glu Asp Ser  Glu Arg Trp 
    2570                 2575                 2580             


Ser Gly  Ser Ala Ser Arg Asn  His His Gly Ser Ala  Gln Glu Gln 
    2585                 2590                 2595             


Leu Arg  Asp Gly Ser Arg His  Pro Arg Ser His Gln  Glu Asp Arg 
    2600                 2605                 2610             


Ala Gly  His Gly His Ser Ala  Asp Ser Ser Arg Gln  Ser Gly Thr 
    2615                 2620                 2625             


Arg His  Thr Gln Thr Ser Ser  Gly Gly Gln Ala Ala  Ser Ser His 
    2630                 2635                 2640             


Glu Gln  Ala Arg Ser Ser Ala  Gly Glu Arg His Gly  Ser His His 
    2645                 2650                 2655             


Gln Gln  Ser Ala Asp Ser Ser  Arg His Ser Gly Ile  Gly His Gly 
    2660                 2665                 2670             


Gln Ala  Ser Ser Ala Val Arg  Asp Ser Gly His Arg  Gly Tyr Ser 
    2675                 2680                 2685             


Gly Ser  Gln Ala Ser Asp Asn  Glu Gly His Ser Glu  Asp Ser Asp 
    2690                 2695                 2700             


Thr Gln  Ser Val Ser Ala His  Gly Gln Ala Gly Ser  His Gln Gln 
    2705                 2710                 2715             


Ser His  Gln Glu Ser Ala Arg  Gly Arg Ser Gly Glu  Thr Ser Gly 
    2720                 2725                 2730             


His Ser  Gly Ser Phe Leu Tyr  Gln Val Ser Thr His  Glu Gln Ser 
    2735                 2740                 2745             


Glu Ser  Ser His Gly Trp Thr  Gly Pro Ser Thr Arg  Gly Arg Gln 
    2750                 2755                 2760             


Gly Ser  Arg His Glu Gln Ala  Gln Asp Ser Ser Arg  His Ser Ala 
    2765                 2770                 2775             


Ser Gln  Asp Gly Gln Asp Thr  Ile Arg Gly His Pro  Gly Ser Ser 
    2780                 2785                 2790             


Arg Gly  Gly Arg Gln Gly Tyr  His His Glu His Ser  Val Asp Ser 
    2795                 2800                 2805             


Ser Gly  His Ser Gly Ser His  His Ser His Thr Thr  Ser Gln Gly 
    2810                 2815                 2820             


Arg Ser  Asp Ala Ser Arg Gly  Gln Ser Gly Ser Arg  Ser Ala Ser 
    2825                 2830                 2835             


Arg Thr  Thr Arg Asn Glu Glu  Gln Ser Gly Asp Gly  Ser Arg His 
    2840                 2845                 2850             


Ser Gly  Ser Arg His His Glu  Ala Ser Thr His Ala  Asp Ile Ser 
    2855                 2860                 2865             


Arg His  Ser Gln Ala Val Gln  Gly Gln Ser Glu Gly  Ser Arg Arg 
    2870                 2875                 2880             


Ser Arg  Arg Gln Gly Ser Ser  Val Ser Gln Asp Ser  Asp Ser Glu 
    2885                 2890                 2895             


Gly His  Ser Glu Asp Ser Glu  Arg Trp Ser Gly Ser  Ala Ser Arg 
    2900                 2905                 2910             


Asn His  His Gly Ser Ala Gln  Glu Gln Leu Arg Asp  Gly Ser Arg 
    2915                 2920                 2925             


His Pro  Arg Ser His Gln Glu  Asp Arg Ala Gly His  Gly His Ser 
    2930                 2935                 2940             


Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Arg His Thr  Gln Thr Ser 
    2945                 2950                 2955             


Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu Gln Ala  Arg Ser Ser 
    2960                 2965                 2970             


Ala Gly  Glu Arg His Gly Ser  His His Gln Gln Ser  Ala Asp Ser 
    2975                 2980                 2985             


Ser Arg  His Ser Gly Ile Gly  His Gly Gln Ala Ser  Ser Ala Val 
    2990                 2995                 3000             


Arg Asp  Ser Gly His Arg Gly  Tyr Ser Gly Ser Gln  Ala Ser Asp 
    3005                 3010                 3015             


Asn Glu  Gly His Ser Glu Asp  Ser Asp Thr Gln Ser  Val Ser Ala 
    3020                 3025                 3030             


His Gly  Gln Ala Gly Ser His  Gln Gln Ser His Gln  Glu Ser Ala 
    3035                 3040                 3045             


Arg Gly  Arg Ser Gly Glu Thr  Ser Gly His Ser Gly  Ser Phe Leu 
    3050                 3055                 3060             


Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu Ser Ser  His Gly Trp 
    3065                 3070                 3075             


Thr Gly  Pro Ser Thr Arg Gly  Arg Gln Gly Ser Arg  His Glu Gln 
    3080                 3085                 3090             


Ala Gln  Asp Ser Ser Arg His  Ser Ala Ser Gln Tyr  Gly Gln Asp 
    3095                 3100                 3105             


Thr Ile  Arg Gly His Pro Gly  Ser Ser Arg Gly Gly  Arg Gln Gly 
    3110                 3115                 3120             


Tyr His  His Glu His Ser Val  Asp Ser Ser Gly His  Ser Gly Ser 
    3125                 3130                 3135             


His His  Ser His Thr Thr Ser  Gln Gly Arg Ser Asp  Ala Ser Arg 
    3140                 3145                 3150             


Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg Thr Thr  Arg Asn Glu 
    3155                 3160                 3165             


Glu Gln  Ser Gly Asp Ser Ser  Arg His Ser Val Ser  Arg His His 
    3170                 3175                 3180             


Glu Ala  Ser Thr His Ala Asp  Ile Ser Arg His Ser  Gln Ala Val 
    3185                 3190                 3195             


Gln Gly  Gln Ser Glu Gly Ser  Arg Arg Ser Arg Arg  Gln Gly Ser 
    3200                 3205                 3210             


Ser Val  Ser Gln Asp Ser Asp  Ser Glu Gly His Ser  Glu Asp Ser 
    3215                 3220                 3225             


Glu Arg  Trp Ser Gly Ser Ala  Ser Arg Asn His Arg  Gly Ser Val 
    3230                 3235                 3240             


Gln Glu  Gln Ser Arg His Gly  Ser Arg His Pro Arg  Ser His His 
    3245                 3250                 3255             


Glu Asp  Arg Ala Gly His Gly  His Ser Ala Asp Arg  Ser Arg Gln 
    3260                 3265                 3270             


Ser Gly  Thr Arg His Ala Glu  Thr Ser Ser Gly Gly  Gln Ala Ala 
    3275                 3280                 3285             


Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro Gly Glu  Arg His Gly 
    3290                 3295                 3300             


Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser Arg His  Ser Gly Ile 
    3305                 3310                 3315             


Pro Arg  Gly Gln Ala Ser Ser  Ala Val Arg Asp Ser  Arg His Trp 
    3320                 3325                 3330             


Gly Ser  Ser Gly Ser Gln Ala  Ser Asp Ser Glu Gly  His Ser Glu 
    3335                 3340                 3345             


Glu Ser  Asp Thr Gln Ser Val  Ser Gly His Gly Gln  Ala Gly Pro 
    3350                 3355                 3360             


His Gln  Gln Ser His Gln Glu  Ser Ala Arg Asp Arg  Ser Gly Gly 
    3365                 3370                 3375             


Arg Ser  Gly Arg Ser Gly Ser  Phe Leu Tyr Gln Val  Ser Thr His 
    3380                 3385                 3390             


Glu Gln  Ser Glu Ser Ala His  Gly Arg Thr Arg Thr  Ser Thr Gly 
    3395                 3400                 3405             


Arg Arg  Gln Gly Ser His His  Glu Gln Ala Arg Asp  Ser Ser Arg 
    3410                 3415                 3420             


His Ser  Ala Ser Gln Glu Gly  Gln Asp Thr Ile Arg  Gly His Pro 
    3425                 3430                 3435             


Gly Ser  Ser Arg Arg Gly Arg  Gln Gly Ser His Tyr  Glu Gln Ser 
    3440                 3445                 3450             


Val Asp  Arg Ser Gly His Ser  Gly Ser His His Ser  His Thr Thr 
    3455                 3460                 3465             


Ser Gln  Gly Arg Ser Asp Ala  Ser Arg Gly Gln Ser  Gly Ser Arg 
    3470                 3475                 3480             


Ser Ala  Ser Arg Gln Thr Arg  Asn Asp Glu Gln Ser  Gly Asp Gly 
    3485                 3490                 3495             


Ser Arg  His Ser Trp Ser His  His His Glu Ala Ser  Thr Gln Ala 
    3500                 3505                 3510             


Asp Ser  Ser Arg His Ser Gln  Ser Gly Gln Gly Gln  Ser Ala Gly 
    3515                 3520                 3525             


Pro Arg  Thr Ser Arg Asn Gln  Gly Ser Ser Val Ser  Gln Asp Ser 
    3530                 3535                 3540             


Asp Ser  Gln Gly His Ser Glu  Asp Ser Glu Arg Trp  Ser Gly Ser 
    3545                 3550                 3555             


Ala Ser  Arg Asn His Arg Gly  Ser Ala Gln Glu Gln  Ser Arg Asp 
    3560                 3565                 3570             


Gly Ser  Arg His Pro Thr Ser  His His Glu Asp Arg  Ala Gly His 
    3575                 3580                 3585             


Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser Gly Thr  His His Ala 
    3590                 3595                 3600             


Glu Asn  Ser Ser Gly Gly Gln  Ala Ala Ser Ser His  Glu Gln Ala 
    3605                 3610                 3615             


Arg Ser  Ser Ala Gly Glu Arg  His Gly Ser His His  Gln Gln Ser 
    3620                 3625                 3630             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    3635                 3640                 3645             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Ser Ser  Gly Ser Gln 
    3650                 3655                 3660             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    3665                 3670                 3675             


Val Ser  Ala His Gly Gln Ala  Gly Pro His Gln Gln  Ser His Gln 
    3680                 3685                 3690             


Glu Ser  Thr Arg Gly Arg Ser  Ala Gly Arg Ser Gly  Arg Ser Gly 
    3695                 3700                 3705             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Ala 
    3710                 3715                 3720             


His Gly  Arg Ala Gly Pro Ser  Thr Gly Gly Arg Gln  Gly Ser Arg 
    3725                 3730                 3735             


His Glu  Gln Ala Arg Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    3740                 3745                 3750             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Ser Arg  Arg Gly Gly 
    3755                 3760                 3765             


Arg Gln  Gly Ser Tyr His Glu  Gln Ser Val Asp Arg  Ser Gly His 
    3770                 3775                 3780             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    3785                 3790                 3795             


Ala Ser  His Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Glu Thr 
    3800                 3805                 3810             


Arg Asn  Glu Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    3815                 3820                 3825             


Arg His  His Glu Ala Ser Thr  Gln Ala Asp Ser Ser  Arg His Ser 
    3830                 3835                 3840             


Gln Ser  Gly Gln Gly Glu Ser  Ala Gly Ser Arg Arg  Ser Arg Arg 
    3845                 3850                 3855             


Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Ala Tyr Pro 
    3860                 3865                 3870             


Glu Asp  Ser Glu Arg Arg Ser  Glu Ser Ala Ser Arg  Asn His His 
    3875                 3880                 3885             


Gly Ser  Ser Arg Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Gly 
    3890                 3895                 3900             


Ser Ser  His Arg Asp Thr Ala  Ser His Val Gln Ser  Ser Pro Val 
    3905                 3910                 3915             


Gln Ser  Asp Ser Ser Thr Ala  Lys Glu His Gly His  Phe Ser Ser 
    3920                 3925                 3930             


Leu Ser  Gln Asp Ser Ala Tyr  His Ser Gly Ile Gln  Ser Arg Gly 
    3935                 3940                 3945             


Ser Pro  His Ser Ser Ser Ser  Tyr His Tyr Gln Ser  Glu Gly Thr 
    3950                 3955                 3960             


Glu Arg  Gln Lys Gly Gln Ser  Gly Leu Val Trp Arg  His Gly Ser 
    3965                 3970                 3975             


Tyr Gly  Ser Ala Asp Tyr Asp  Tyr Gly Glu Ser Gly  Phe Arg His 
    3980                 3985                 3990             


Ser Gln  His Gly Ser Val Ser  Tyr Asn Ser Asn Pro  Val Val Phe 
    3995                 4000                 4005             


Lys Glu  Arg Ser Asp Ile Cys  Lys Ala Ser Ala Phe  Gly Lys Asp 
    4010                 4015                 4020             


His Pro  Arg Tyr Tyr Ala Thr  Tyr Ile Asn Lys Asp  Pro Gly Leu 
    4025                 4030                 4035             


Cys Gly  His Ser Ser Asp Ile  Ser Lys Gln Leu Gly  Phe Ser Gln 
    4040                 4045                 4050             


Ser Gln  Arg Tyr Tyr Tyr Tyr  Glu 
    4055                 4060     


<210>  281
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  281
accctgcaag ctgcattagg ctttatccta cttgttcctt tggtgaacca gggttcactt     60

aaacttgcaa aaagatgacc gacctcttga gaagtgttgt caccgtaatt gatgttttct    120

acaaatacac caagcaagat ggggagtgtg gcacactgag caagggtgaa ctaaaggaac    180

ttctggagaa agagcttcat ccagttctga agaacccaga tgatccagac acagtggatg    240

tcatcatgca tatgctggat cgagatcatg acagaagatt ggactttact gagtttcttt    300

tgatgatatt caagctgact atggcctgca acaaggtcct cagcaaagaa tactgcaaag    360

cttcagggtc aaagaagcat aggcgtggtc accgacacca agaagaagaa agtgaaacag    420

aagaggatga agaggataca ccaggacata aatcaggtta cagacattca agttggagtg    480

agggagagga gcatggatat agttctgggc actcaagggg aactgtgaaa tgtagacatg    540

ggtccaactc caggaggcta ggaagacaag gtaatttatc cagctctggg aaccaagagg    600

gatctcagaa aagataccac aggtccagct gtggtcattc atggagtggt ggcaaagaca    660

gacatggttc cagctctgta gaactgagag aaagaataaa caagtcacac attagccctt    720

ctagggaatc tggggaggag tatgaatctg gatctggatc aaacagttgg gaaaggaaag    780

gtcatggtgg tctgtcatgt ggattggaga ctagtgggca tgaatcaaac tctactcagt    840

caagaattag agaacaaaag cttgggtcta gctgttcagg ttcaggagac agtgggaggc    900

gaagtcatgc atgtggttat agcaattcaa gtgggtgtgg aaggccacaa aatgcttcaa    960

gttcttgtca gtcacataga tttggagggc aaggaaatca atttagctat attcagtcag   1020

gctgtcagtc aggaattaag ggaggacaag gccatggctg tgtctcagga ggtcagccct   1080

ctggatgtgg tcaacctgag tctaacccct gtagtcagtc ctatagtcag agaggatatg   1140

gagctagaga aaatggtcaa ccacagaact gtggaggaca atggagaaca ggctcaagtc   1200

agtcctcttg ctgtggacaa tatgggtctg gaggtagcca gtcttgtagt aatggtcaac   1260

atgaatatgg ttcctgtggc cgcttttcaa actcttctag ttcaaatgaa ttttccaaat   1320

gtgatcaata tgggtctggt tcaagtcagt ctactagctt tgaacaacat ggaacaggct   1380

tgagtcagtc ctctgggttc gaacaacatg tatgtggctc aggtcaaact tgtggccagc   1440

atgagtctac atcaagtcaa tccttgggct atgaccagca tgggtctagc tcaggtaaga   1500

catctggctt tggacaacat gggtctggct caggtcagtc ctctggcttt ggacaatgtg   1560

ggtcaggctc aggtcagtcc tctggctttg gacagcatgg gtctgtctca ggacaatcct   1620

ctggttttgg acagcatggg tctgtctcag gacaatcctc tggttttgga caacatgagt   1680

ctagatcacg tcagtctagc tatggccaac atggttctgg ctcaagtcaa tcatctggct   1740

atggccaata tgggtctaga gagacatctg gctttggaca acatgggttg ggctcaggtc   1800

aatccactgg ctttggccaa tatggatcgg gctcaggtca gtcctctggc tttggacaac   1860

atgggtctgg ctcaggacaa tcctctggct ttggacaaca tgagtctaga tcaggtcagt   1920

ctagttatgg ccaacacagt tctggctcaa gtcagtcatc tggctatggc caacatgggt   1980

ctagacagac atctggcttt ggacaacatg ggtcaggctc aagtcaatcc actggctttg   2040

gccaatatgg atcaggctca ggtcagtcct ctggctttgg acaacatgtt tctggctcag   2100

gacaatcctc tggttttgga caacatgagt ctagatcagg tcattctagc tatggccaac   2160

atggttttgg ctcaagtcaa tcatctggct atggtcaaca tgggtcaagt tcaggacaga   2220

catctggatt tggacaacac gagttaagct caggtcagtc ttccagcttt ggccaacatg   2280

gatcaggctc aggtcagtcc tctggctttg gacaacatgg gtctggctca ggacaatcct   2340

ctggctttgg acaacatgag tctagatcag gtcagtctag ctatggccaa cacagttctg   2400

gctcaagtca gtcatctggc tatggccaac atgggtctag acagacatct ggctttggac   2460

aacatgggtc aggctcaagt caatccactg gctttggcca atatggatca ggctcaggtc   2520

agtccgctgg ctttggacaa catgggtctg gctcaggaca atcctctggc tttggacagc   2580

atgagtctag atcacatcag tccagctatg gccaacatgg ttctggctca agtcaatcat   2640

ctggctatgg tcaacatggg tcaagttcgg gacagacatc tggctttgga caacacaggt   2700

caagctcagg tcaatactct ggctttggac aacatggatc aggctcaggt cagtccagtg   2760

gctttggaca acatgggact ggctcaggac aatactctgg ttttggacaa catgagtcta   2820

gatcacatca gtctagctat ggccaacatg gttctggctc aagtcagtca tctggctatg   2880

gtcaacatgg gtcaagttca ggacagactt ttggatttgg acaacacagg tcaggctcag   2940

gtcaatcctc tggctttggc caacatggat caggctcagg tcagtcctct ggctttggac   3000

aacatgagtc aggctcagga aaatcctctg gctttggaca gcatgagtct agatcaagtc   3060

agtctaatta tggccaacat ggttctggct caagtcagtc atctggctat ggtcaacatg   3120

ggtctagttc aggacagaca actggctttg gacaacacag gtcaagctca ggccaatact   3180

caggctttgg acaacatgga tcaggctcag atcagtcctc tggctttgga caacatggga   3240

ctggttcagg acaatcctct ggttttggac aatatgagtc tagatcacgt cagtctagct   3300

atggccaaca tggttctggc tcaagtcaat catctggcta tggtcaacat gggtcaaatt   3360

caggacagac atctggattt ggacaacaca ggccaggctc aggtcagtcc tctggctttg   3420

gccaatatgg atcgggctca ggtcagtctt ctggctttgg acaacatggg tcaggcacag   3480

gtaaatcctc tggctttgca cagcatgagt acagatcagg tcagtctagc tatggccaac   3540

atggtactgg ctccagtcaa tcatctggct gtggccaaca tgagtctggc tcaggtccaa   3600

ccacaagttt tggacagcat gtgtctggct cagacaattt ctctagttct ggacaacata   3660

tatctgactc aggtcagtcc actggatttg gccaatatgg ttcaggctca ggtcaatcaa   3720

ctggcttggg ccagggtgaa tctcaacaag tagagtcagg atccacagtt catgggagac   3780

aggaaactac tcatggtcag acaataaata ccactagaca tagccagtct ggtcaaggac   3840

aatccacaca gacagggtcc agggtaacta gaagacgaag atctagccaa agtgagaaca   3900

gtgacagtga agtgcactca aaggtctcac acagacattc agaacacatt cacacacaag   3960

ctggatctca ctacccaaag tcaggatcca cagttcgcag aagacaagga actactcatg   4020

gacagagagg agataccact agacatggcc attctggtca tggacagtct acacagacag   4080

gttccagaac atctggaaga cagagattta gccacagtga tgccactgac agtgaagtgc   4140

actcaggggt ctcacataga ccacactcac aagaacaaac tcacagccaa gctggatctc   4200

aacatggaga gtcagaatcc acagttcatg agagacatga aactacttat ggacagacag   4260

gagaggccac tggacatggc cactctggtc atggacagtc cacacagaga gggtccagga   4320

caactggaag aaggggatct ggccatagtg agtccagtga cagtgaagtg cactcagggg   4380

gctcacacag accacaatca caagaacaaa ctcatggcca agccggatct caacatggag   4440

agtcaggatc cacagttcat gggagacacg gaactactca tggacagaca ggagatacca   4500

ctagacatgc ccactatcat catggaaaat ccacacagag agggtccagt acaactggaa   4560

gaaggggatc tggccacagt gagtccagtg acagtgaagt gcactcaggg ggctcgcaca   4620

cacattcagg acacactcac ggccaaagtg gatctcaaca tggagagtca gaatccataa   4680

ttcatgacag acacagaatt actcatggac agacaggaga taccactaga cattcctact   4740

ctggtcatga acaaaccaca cagacagggt ccaggacaac tggaagacag agaactagcc   4800

acagtgagtc cactgacagt gaagtgcact cagggggctc acacagacca cactcacgag   4860

aacacactta cggccaagcc ggatctcaac atgaagagcc agaattcaca gttcatgaga   4920

gacacggaac tactcatgga cagataggag ataccactgg acattcccac tctggtcatg   4980

gacagtccac acagagaggg tccaggacaa ctggaagaca gagatctagc cacagtgagt   5040

ccagtgacag tgaagtgcac tcaggggtct cacacacaca tacaggacac actcatggtc   5100

aagctggatc tcaacatgga cagtcagaat ccatagttcc tgagagacat ggaactactc   5160

atggacagac aggagatacc actagacatg cccactatca tcatggatta accacacaga   5220

cagggtccag gactactgga agaaggggat ctggccacag tgagtacagt gacagtgaag   5280

ggtactcagg agtctcacat acacattcag gacacactca tggccaagcc agatctcaac   5340

atggagagtc agaatccata gttcatgaga gacatggaac tatacatgga cagacaggcg   5400

ataccaccag acatgcccac tctggtcatg gacagtccac acagacaggg tccaggacca   5460

ctggaagaag gtcatctggc cacagtgagt acagtgacag tgaagggcac tcagggttct   5520

cacaaagacc acactcacga ggacacactc acggccaggc tggatctcaa catggagagt   5580

cagaatccat agttgacgag agacatggaa ctactcatgg acagacagga gataccagtg   5640

gacattctca atctggtcat ggacagtcca cacagtcagg atccagtaca actggaagaa   5700

ggagatctgg ccacagtgag tccagtgaca gtgaagtgca ctcagggggc tcacatacac   5760

attcaggaca cacacacagc caagccaggt ctcaacatgg agagtcagaa tccacagttc   5820

acaagagaca ccaaactact catggacaga caggagatac cactgaacat ggccacccta   5880

gtcatggaca aaccatacag acagggtcca ggacaactgg aagaagggga tctggccaca   5940

gtgagtacag tgacagtgaa gggccctcag gggtctcaca cacacattca ggacacactc   6000

acggtcaagc tggatctcac tatccagagt caggatcctc agttcatgag agacacggaa   6060

ctactcatgg acaaacagca gataccacta gacatggcca ctctggtcat ggacagtcca   6120

cacagagagg gtccaggaca actggaagaa gggcatctgg ccacagtgag tacagtgaca   6180

gtgaagggca ctcaggggtc tcacacacac attcaggaca cgctcatggc caagccggat   6240

ctcaacatgg agagtcagga tcctcagttc atgagagaca cggaactact catggacaga   6300

caggagatac cactagacat gctcactctg gtcatggaca gtccacacag agagggtcaa   6360

ggacagctgg aagaagggga tctggccaca gtgagtccag tgacagtgaa gtgcactcag   6420

gggtctcaca cacacattca ggacacactt atggccaagc cagatctcaa catggagagt   6480

caggatctgc cattcacggg agacagggaa ctatacatgg acagacagga gataccacta   6540

gacatggcca gtctggtcat ggacagtcca cacagacagg ttccaggaca actggaagac   6600

aaagatctag tcacagtgag tccagtgata gtgaagtgca ctcagaggcc tcacccacac   6660

attcaggaca cactcacagc caagccggat ctcgacatgg acagtcagga tcctcaggtc   6720

atgggagaca gggaactact catggacaga caggagatac cactagacat gcccactatg   6780

gttatggaca atccacacag agagggtcca ggacaactgg aagaagggga tctggccaca   6840

gtgagtccag tgacagtgaa gtgcactcat ggggctcaca cacacattca ggacacattc   6900

agggccaagc tggatctcaa caaagacagc caggatccac agttcatggg agactggaaa   6960

ctactcatgg acagacagga gataccacta gacatggcca ttctggttat ggacaatcca   7020

cacagacagg ttccagatct agtagagcaa gtcattttca gtcacatagt agtgaaaggc   7080

aaaggcatgg atcaagtcag gtttggaaac atggcagcta tggacctgca gaatatgact   7140

atgggcacac tgggtatggg ccttctggtg gcagcagaaa aagcatcagt aattctcacc   7200

tttcatggtc aacagacagc actgcaaaca agcaactgtc tagacattga cagttatttt   7260

ctagttctga ccttatagta tccaaagcaa ctaaaagaac aggaagacac agtttaaatc   7320

atgaacagtc aatggtaagt tatgaacatt cagttgattc tcagtatcag tctcgaccta   7380

ttattataag aagtcaggaa tctagtcatg gacattctat agtaactcat aaacagtcaa   7440

acaacaccta tgttcaacct ggatataaca cagccagaag ggagggatgt acacatagcc   7500

agtcaaatga ccaccttgga tttggccatg gacaatccat atcagttcat ggccattcaa   7560

aatctagttc aatcagaaaa caggaatccc atactgataa caaaaagcat tcagaagatt   7620

gggagaaaga cactcatgag caattaggat ctaggcatgg gaagttagag ttcaatacaa   7680

taggtataca tggatctagc cagcaacatt tcggagatac aacttttcat gggcaggtaa   7740

gatccagcac aggttttgcc agataggtat taagtcatgg gccatcaaga gatgcctagg   7800

gtcagtctgg attcagtacc aatgaaagac aagtatacag ccatggccaa tcaaatgata   7860

gttatgagta gtcaaatgac agcaaaagtc aaagatacat tttcagtcac tttcttgaca   7920

gccaagaccc tgcaggaatt gaagagtata ggtatagata ttcatcaagc agtgcaacca   7980

tatgcagtgg gggagacaaa ggcaagagtc agagtcaagt ctgtcaggag gtatcagaat   8040

atacggtgag gatgtgggca aaaaacaaag aggctctgag gccagcggtt accatacaaa   8100

ggaaagaaca ggctctggtt ccttctgctt agatagcaac accccactct atgaatatgt   8160

ccaagaacaa aggagttatt actttgaata ag                                 8192


<210>  282
<211>  2391
<212>  PRT
<213>  Homosapiens

<400>  282

Met Thr Asp Leu Leu Arg Ser Val Val Thr Val Ile Asp Val Phe Tyr 
1               5                   10                  15      


Lys Tyr Thr Lys Gln Asp Gly Glu Cys Gly Thr Leu Ser Lys Gly Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Leu His Pro Val Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Thr Val Asp Val Ile Met His Met Leu Asp Arg Asp 
    50                  55                  60                  


His Asp Arg Arg Leu Asp Phe Thr Glu Phe Leu Leu Met Ile Phe Lys 
65                  70                  75                  80  


Leu Thr Met Ala Cys Asn Lys Val Leu Ser Lys Glu Tyr Cys Lys Ala 
                85                  90                  95      


Ser Gly Ser Lys Lys His Arg Arg Gly His Arg His Gln Glu Glu Glu 
            100                 105                 110         


Ser Glu Thr Glu Glu Asp Glu Glu Asp Thr Pro Gly His Lys Ser Gly 
        115                 120                 125             


Tyr Arg His Ser Ser Trp Ser Glu Gly Glu Glu His Gly Tyr Ser Ser 
    130                 135                 140                 


Gly His Ser Arg Gly Thr Val Lys Cys Arg His Gly Ser Asn Ser Arg 
145                 150                 155                 160 


Arg Leu Gly Arg Gln Gly Asn Leu Ser Ser Ser Gly Asn Gln Glu Gly 
                165                 170                 175     


Ser Gln Lys Arg Tyr His Arg Ser Ser Cys Gly His Ser Trp Ser Gly 
            180                 185                 190         


Gly Lys Asp Arg His Gly Ser Ser Ser Val Glu Leu Arg Glu Arg Ile 
        195                 200                 205             


Asn Lys Ser His Ile Ser Pro Ser Arg Glu Ser Gly Glu Glu Tyr Glu 
    210                 215                 220                 


Ser Gly Ser Gly Ser Asn Ser Trp Glu Arg Lys Gly His Gly Gly Leu 
225                 230                 235                 240 


Ser Cys Gly Leu Glu Thr Ser Gly His Glu Ser Asn Ser Thr Gln Ser 
                245                 250                 255     


Arg Ile Arg Glu Gln Lys Leu Gly Ser Ser Cys Ser Gly Ser Gly Asp 
            260                 265                 270         


Ser Gly Arg Arg Ser His Ala Cys Gly Tyr Ser Asn Ser Ser Gly Cys 
        275                 280                 285             


Gly Arg Pro Gln Asn Ala Ser Ser Ser Cys Gln Ser His Arg Phe Gly 
    290                 295                 300                 


Gly Gln Gly Asn Gln Phe Ser Tyr Ile Gln Ser Gly Cys Gln Ser Gly 
305                 310                 315                 320 


Ile Lys Gly Gly Gln Gly His Gly Cys Val Ser Gly Gly Gln Pro Ser 
                325                 330                 335     


Gly Cys Gly Gln Pro Glu Ser Asn Pro Cys Ser Gln Ser Tyr Ser Gln 
            340                 345                 350         


Arg Gly Tyr Gly Ala Arg Glu Asn Gly Gln Pro Gln Asn Cys Gly Gly 
        355                 360                 365             


Gln Trp Arg Thr Gly Ser Ser Gln Ser Ser Cys Cys Gly Gln Tyr Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gln Ser Cys Ser Asn Gly Gln His Glu Tyr Gly Ser 
385                 390                 395                 400 


Cys Gly Arg Phe Ser Asn Ser Ser Ser Ser Asn Glu Phe Ser Lys Cys 
                405                 410                 415     


Asp Gln Tyr Gly Ser Gly Ser Ser Gln Ser Thr Ser Phe Glu Gln His 
            420                 425                 430         


Gly Thr Gly Leu Ser Gln Ser Ser Gly Phe Glu Gln His Val Cys Gly 
        435                 440                 445             


Ser Gly Gln Thr Cys Gly Gln His Glu Ser Thr Ser Ser Gln Ser Leu 
    450                 455                 460                 


Gly Tyr Asp Gln His Gly Ser Ser Ser Gly Lys Thr Ser Gly Phe Gly 
465                 470                 475                 480 


Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln Cys Gly 
                485                 490                 495     


Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Gly Ser Val Ser 
            500                 505                 510         


Gly Gln Ser Ser Gly Phe Gly Gln His Gly Ser Val Ser Gly Gln Ser 
        515                 520                 525             


Ser Gly Phe Gly Gln His Glu Ser Arg Ser Arg Gln Ser Ser Tyr Gly 
    530                 535                 540                 


Gln His Gly Ser Gly Ser Ser Gln Ser Ser Gly Tyr Gly Gln Tyr Gly 
545                 550                 555                 560 


Ser Arg Glu Thr Ser Gly Phe Gly Gln His Gly Leu Gly Ser Gly Gln 
                565                 570                 575     


Ser Thr Gly Phe Gly Gln Tyr Gly Ser Gly Ser Gly Gln Ser Ser Gly 
            580                 585                 590         


Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln 
        595                 600                 605             


His Glu Ser Arg Ser Gly Gln Ser Ser Tyr Gly Gln His Ser Ser Gly 
    610                 615                 620                 


Ser Ser Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Arg Gln Thr Ser 
625                 630                 635                 640 


Gly Phe Gly Gln His Gly Ser Gly Ser Ser Gln Ser Thr Gly Phe Gly 
                645                 650                 655     


Gln Tyr Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Val 
            660                 665                 670         


Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Glu Ser Arg Ser 
        675                 680                 685             


Gly His Ser Ser Tyr Gly Gln His Gly Phe Gly Ser Ser Gln Ser Ser 
    690                 695                 700                 


Gly Tyr Gly Gln His Gly Ser Ser Ser Gly Gln Thr Ser Gly Phe Gly 
705                 710                 715                 720 


Gln His Glu Leu Ser Ser Gly Gln Ser Ser Ser Phe Gly Gln His Gly 
                725                 730                 735     


Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Gly Ser Gly Ser 
            740                 745                 750         


Gly Gln Ser Ser Gly Phe Gly Gln His Glu Ser Arg Ser Gly Gln Ser 
        755                 760                 765             


Ser Tyr Gly Gln His Ser Ser Gly Ser Ser Gln Ser Ser Gly Tyr Gly 
    770                 775                 780                 


Gln His Gly Ser Arg Gln Thr Ser Gly Phe Gly Gln His Gly Ser Gly 
785                 790                 795                 800 


Ser Ser Gln Ser Thr Gly Phe Gly Gln Tyr Gly Ser Gly Ser Gly Gln 
                805                 810                 815     


Ser Ala Gly Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly 
            820                 825                 830         


Phe Gly Gln His Glu Ser Arg Ser His Gln Ser Ser Tyr Gly Gln His 
        835                 840                 845             


Gly Ser Gly Ser Ser Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Ser 
    850                 855                 860                 


Ser Gly Gln Thr Ser Gly Phe Gly Gln His Arg Ser Ser Ser Gly Gln 
865                 870                 875                 880 


Tyr Ser Gly Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly 
                885                 890                 895     


Phe Gly Gln His Gly Thr Gly Ser Gly Gln Tyr Ser Gly Phe Gly Gln 
            900                 905                 910         


His Glu Ser Arg Ser His Gln Ser Ser Tyr Gly Gln His Gly Ser Gly 
        915                 920                 925             


Ser Ser Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Ser Ser Gly Gln 
    930                 935                 940                 


Thr Phe Gly Phe Gly Gln His Arg Ser Gly Ser Gly Gln Ser Ser Gly 
945                 950                 955                 960 


Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln 
                965                 970                 975     


His Glu Ser Gly Ser Gly Lys Ser Ser Gly Phe Gly Gln His Glu Ser 
            980                 985                 990         


Arg Ser Ser Gln Ser Asn Tyr Gly  Gln His Gly Ser Gly  Ser Ser Gln 
        995                 1000                 1005             


Ser Ser  Gly Tyr Gly Gln His  Gly Ser Ser Ser Gly  Gln Thr Thr 
    1010                 1015                 1020             


Gly Phe  Gly Gln His Arg Ser  Ser Ser Gly Gln Tyr  Ser Gly Phe 
    1025                 1030                 1035             


Gly Gln  His Gly Ser Gly Ser  Asp Gln Ser Ser Gly  Phe Gly Gln 
    1040                 1045                 1050             


His Gly  Thr Gly Ser Gly Gln  Ser Ser Gly Phe Gly  Gln Tyr Glu 
    1055                 1060                 1065             


Ser Arg  Ser Arg Gln Ser Ser  Tyr Gly Gln His Gly  Ser Gly Ser 
    1070                 1075                 1080             


Ser Gln  Ser Ser Gly Tyr Gly  Gln His Gly Ser Asn  Ser Gly Gln 
    1085                 1090                 1095             


Thr Ser  Gly Phe Gly Gln His  Arg Pro Gly Ser Gly  Gln Ser Ser 
    1100                 1105                 1110             


Gly Phe  Gly Gln Tyr Gly Ser  Gly Ser Gly Gln Ser  Ser Gly Phe 
    1115                 1120                 1125             


Gly Gln  His Gly Ser Gly Thr  Gly Lys Ser Ser Gly  Phe Ala Gln 
    1130                 1135                 1140             


His Glu  Tyr Arg Ser Gly Gln  Ser Ser Tyr Gly Gln  His Gly Thr 
    1145                 1150                 1155             


Gly Ser  Ser Gln Ser Ser Gly  Cys Gly Gln His Glu  Ser Gly Ser 
    1160                 1165                 1170             


Gly Pro  Thr Thr Ser Phe Gly  Gln His Val Ser Gly  Ser Asp Asn 
    1175                 1180                 1185             


Phe Ser  Ser Ser Gly Gln His  Ile Ser Asp Ser Gly  Gln Ser Thr 
    1190                 1195                 1200             


Gly Phe  Gly Gln Tyr Gly Ser  Gly Ser Gly Gln Ser  Thr Gly Leu 
    1205                 1210                 1215             


Gly Gln  Gly Glu Ser Gln Gln  Val Glu Ser Gly Ser  Thr Val His 
    1220                 1225                 1230             


Gly Arg  Gln Glu Thr Thr His  Gly Gln Thr Ile Asn  Thr Thr Arg 
    1235                 1240                 1245             


His Ser  Gln Ser Gly Gln Gly  Gln Ser Thr Gln Thr  Gly Ser Arg 
    1250                 1255                 1260             


Val Thr  Arg Arg Arg Arg Ser  Ser Gln Ser Glu Asn  Ser Asp Ser 
    1265                 1270                 1275             


Glu Val  His Ser Lys Val Ser  His Arg His Ser Glu  His Ile His 
    1280                 1285                 1290             


Thr Gln  Ala Gly Ser His Tyr  Pro Lys Ser Gly Ser  Thr Val Arg 
    1295                 1300                 1305             


Arg Arg  Gln Gly Thr Thr His  Gly Gln Arg Gly Asp  Thr Thr Arg 
    1310                 1315                 1320             


His Gly  His Ser Gly His Gly  Gln Ser Thr Gln Thr  Gly Ser Arg 
    1325                 1330                 1335             


Thr Ser  Gly Arg Gln Arg Phe  Ser His Ser Asp Ala  Thr Asp Ser 
    1340                 1345                 1350             


Glu Val  His Ser Gly Val Ser  His Arg Pro His Ser  Gln Glu Gln 
    1355                 1360                 1365             


Thr His  Ser Gln Ala Gly Ser  Gln His Gly Glu Ser  Glu Ser Thr 
    1370                 1375                 1380             


Val His  Glu Arg His Glu Thr  Thr Tyr Gly Gln Thr  Gly Glu Ala 
    1385                 1390                 1395             


Thr Gly  His Gly His Ser Gly  His Gly Gln Ser Thr  Gln Arg Gly 
    1400                 1405                 1410             


Ser Arg  Thr Thr Gly Arg Arg  Gly Ser Gly His Ser  Glu Ser Ser 
    1415                 1420                 1425             


Asp Ser  Glu Val His Ser Gly  Gly Ser His Arg Pro  Gln Ser Gln 
    1430                 1435                 1440             


Glu Gln  Thr His Gly Gln Ala  Gly Ser Gln His Gly  Glu Ser Gly 
    1445                 1450                 1455             


Ser Thr  Val His Gly Arg His  Gly Thr Thr His Gly  Gln Thr Gly 
    1460                 1465                 1470             


Asp Thr  Thr Arg His Ala His  Tyr His His Gly Lys  Ser Thr Gln 
    1475                 1480                 1485             


Arg Gly  Ser Ser Thr Thr Gly  Arg Arg Gly Ser Gly  His Ser Glu 
    1490                 1495                 1500             


Ser Ser  Asp Ser Glu Val His  Ser Gly Gly Ser His  Thr His Ser 
    1505                 1510                 1515             


Gly His  Thr His Gly Gln Ser  Gly Ser Gln His Gly  Glu Ser Glu 
    1520                 1525                 1530             


Ser Ile  Ile His Asp Arg His  Arg Ile Thr His Gly  Gln Thr Gly 
    1535                 1540                 1545             


Asp Thr  Thr Arg His Ser Tyr  Ser Gly His Glu Gln  Thr Thr Gln 
    1550                 1555                 1560             


Thr Gly  Ser Arg Thr Thr Gly  Arg Gln Arg Thr Ser  His Ser Glu 
    1565                 1570                 1575             


Ser Thr  Asp Ser Glu Val His  Ser Gly Gly Ser His  Arg Pro His 
    1580                 1585                 1590             


Ser Arg  Glu His Thr Tyr Gly  Gln Ala Gly Ser Gln  His Glu Glu 
    1595                 1600                 1605             


Pro Glu  Phe Thr Val His Glu  Arg His Gly Thr Thr  His Gly Gln 
    1610                 1615                 1620             


Ile Gly  Asp Thr Thr Gly His  Ser His Ser Gly His  Gly Gln Ser 
    1625                 1630                 1635             


Thr Gln  Arg Gly Ser Arg Thr  Thr Gly Arg Gln Arg  Ser Ser His 
    1640                 1645                 1650             


Ser Glu  Ser Ser Asp Ser Glu  Val His Ser Gly Val  Ser His Thr 
    1655                 1660                 1665             


His Thr  Gly His Thr His Gly  Gln Ala Gly Ser Gln  His Gly Gln 
    1670                 1675                 1680             


Ser Glu  Ser Ile Val Pro Glu  Arg His Gly Thr Thr  His Gly Gln 
    1685                 1690                 1695             


Thr Gly  Asp Thr Thr Arg His  Ala His Tyr His His  Gly Leu Thr 
    1700                 1705                 1710             


Thr Gln  Thr Gly Ser Arg Thr  Thr Gly Arg Arg Gly  Ser Gly His 
    1715                 1720                 1725             


Ser Glu  Tyr Ser Asp Ser Glu  Gly Tyr Ser Gly Val  Ser His Thr 
    1730                 1735                 1740             


His Ser  Gly His Thr His Gly  Gln Ala Arg Ser Gln  His Gly Glu 
    1745                 1750                 1755             


Ser Glu  Ser Ile Val His Glu  Arg His Gly Thr Ile  His Gly Gln 
    1760                 1765                 1770             


Thr Gly  Asp Thr Thr Arg His  Ala His Ser Gly His  Gly Gln Ser 
    1775                 1780                 1785             


Thr Gln  Thr Gly Ser Arg Thr  Thr Gly Arg Arg Ser  Ser Gly His 
    1790                 1795                 1800             


Ser Glu  Tyr Ser Asp Ser Glu  Gly His Ser Gly Phe  Ser Gln Arg 
    1805                 1810                 1815             


Pro His  Ser Arg Gly His Thr  His Gly Gln Ala Gly  Ser Gln His 
    1820                 1825                 1830             


Gly Glu  Ser Glu Ser Ile Val  Asp Glu Arg His Gly  Thr Thr His 
    1835                 1840                 1845             


Gly Gln  Thr Gly Asp Thr Ser  Gly His Ser Gln Ser  Gly His Gly 
    1850                 1855                 1860             


Gln Ser  Thr Gln Ser Gly Ser  Ser Thr Thr Gly Arg  Arg Arg Ser 
    1865                 1870                 1875             


Gly His  Ser Glu Ser Ser Asp  Ser Glu Val His Ser  Gly Gly Ser 
    1880                 1885                 1890             


His Thr  His Ser Gly His Thr  His Ser Gln Ala Arg  Ser Gln His 
    1895                 1900                 1905             


Gly Glu  Ser Glu Ser Thr Val  His Lys Arg His Gln  Thr Thr His 
    1910                 1915                 1920             


Gly Gln  Thr Gly Asp Thr Thr  Glu His Gly His Pro  Ser His Gly 
    1925                 1930                 1935             


Gln Thr  Ile Gln Thr Gly Ser  Arg Thr Thr Gly Arg  Arg Gly Ser 
    1940                 1945                 1950             


Gly His  Ser Glu Tyr Ser Asp  Ser Glu Gly Pro Ser  Gly Val Ser 
    1955                 1960                 1965             


His Thr  His Ser Gly His Thr  His Gly Gln Ala Gly  Ser His Tyr 
    1970                 1975                 1980             


Pro Glu  Ser Gly Ser Ser Val  His Glu Arg His Gly  Thr Thr His 
    1985                 1990                 1995             


Gly Gln  Thr Ala Asp Thr Thr  Arg His Gly His Ser  Gly His Gly 
    2000                 2005                 2010             


Gln Ser  Thr Gln Arg Gly Ser  Arg Thr Thr Gly Arg  Arg Ala Ser 
    2015                 2020                 2025             


Gly His  Ser Glu Tyr Ser Asp  Ser Glu Gly His Ser  Gly Val Ser 
    2030                 2035                 2040             


His Thr  His Ser Gly His Ala  His Gly Gln Ala Gly  Ser Gln His 
    2045                 2050                 2055             


Gly Glu  Ser Gly Ser Ser Val  His Glu Arg His Gly  Thr Thr His 
    2060                 2065                 2070             


Gly Gln  Thr Gly Asp Thr Thr  Arg His Ala His Ser  Gly His Gly 
    2075                 2080                 2085             


Gln Ser  Thr Gln Arg Gly Ser  Arg Thr Ala Gly Arg  Arg Gly Ser 
    2090                 2095                 2100             


Gly His  Ser Glu Ser Ser Asp  Ser Glu Val His Ser  Gly Val Ser 
    2105                 2110                 2115             


His Thr  His Ser Gly His Thr  Tyr Gly Gln Ala Arg  Ser Gln His 
    2120                 2125                 2130             


Gly Glu  Ser Gly Ser Ala Ile  His Gly Arg Gln Gly  Thr Ile His 
    2135                 2140                 2145             


Gly Gln  Thr Gly Asp Thr Thr  Arg His Gly Gln Ser  Gly His Gly 
    2150                 2155                 2160             


Gln Ser  Thr Gln Thr Gly Ser  Arg Thr Thr Gly Arg  Gln Arg Ser 
    2165                 2170                 2175             


Ser His  Ser Glu Ser Ser Asp  Ser Glu Val His Ser  Glu Ala Ser 
    2180                 2185                 2190             


Pro Thr  His Ser Gly His Thr  His Ser Gln Ala Gly  Ser Arg His 
    2195                 2200                 2205             


Gly Gln  Ser Gly Ser Ser Gly  His Gly Arg Gln Gly  Thr Thr His 
    2210                 2215                 2220             


Gly Gln  Thr Gly Asp Thr Thr  Arg His Ala His Tyr  Gly Tyr Gly 
    2225                 2230                 2235             


Gln Ser  Thr Gln Arg Gly Ser  Arg Thr Thr Gly Arg  Arg Gly Ser 
    2240                 2245                 2250             


Gly His  Ser Glu Ser Ser Asp  Ser Glu Val His Ser  Trp Gly Ser 
    2255                 2260                 2265             


His Thr  His Ser Gly His Ile  Gln Gly Gln Ala Gly  Ser Gln Gln 
    2270                 2275                 2280             


Arg Gln  Pro Gly Ser Thr Val  His Gly Arg Leu Glu  Thr Thr His 
    2285                 2290                 2295             


Gly Gln  Thr Gly Asp Thr Thr  Arg His Gly His Ser  Gly Tyr Gly 
    2300                 2305                 2310             


Gln Ser  Thr Gln Thr Gly Ser  Arg Ser Ser Arg Ala  Ser His Phe 
    2315                 2320                 2325             


Gln Ser  His Ser Ser Glu Arg  Gln Arg His Gly Ser  Ser Gln Val 
    2330                 2335                 2340             


Trp Lys  His Gly Ser Tyr Gly  Pro Ala Glu Tyr Asp  Tyr Gly His 
    2345                 2350                 2355             


Thr Gly  Tyr Gly Pro Ser Gly  Gly Ser Arg Lys Ser  Ile Ser Asn 
    2360                 2365                 2370             


Ser His  Leu Ser Trp Ser Thr  Asp Ser Thr Ala Asn  Lys Gln Leu 
    2375                 2380                 2385             


Ser Arg  His 
    2390     


<210>  283
<211>  1891
<212>  DNA
<213>  Homosapiens

<400>  283
cacttaacag ccacttgttt catcccacct gggcattagg ttgacttcaa agatgcctca     60

gttactgcaa aacattaatg ggatcatcga ggccttcagg cgctatgcaa ggacggaggg    120

caactgcaca gcgctcaccc gaggggagct gaaaagactc ttggagcaag agtttgccga    180

tgtgattgtg aaaccccacg atccagcaac tgtggatgag gtcctgcgtc tgctggatga    240

agaccacaca gggactgtgg aattcaagga attcctggtc ttagtgttta aagttgccca    300

ggcctgtttc aagacactga gcgagagtgc tgagggagcc tgcggctctc aagagtctgg    360

aagcctccac tctggggcct cgcaggagct gggcgaagga cagagaagtg gcactgaagt    420

gggaagggcg gggaaagggc agcattatga ggggagcagc cacagacaga gccagcaggg    480

ttccagaggg cagaacaggc ctggggttca gacccagggt caggccactg gctctgcgtg    540

ggtcagcagc tatgacaggc aagctgagtc ccagagccag gaaagaataa gcccgcagat    600

acaactctct gggcagacag agcagaccca gaaagctgga gaaggcaaga ggaatcagac    660

aacagagatg aggccagaga gacagccaca gaccagggaa caggacagag cccaccagac    720

aggtgagact gtgactggat ctggaactca gacccaggca ggtgccaccc agactgtgga    780

gcaggacagc agccaccaga caggaagaac cagcaagcag acacaggagg ccaccaatga    840

ccagaacaga gggactgaga cccacggtca aggcaggagc cagaccagcc aggctgtgac    900

aggaggacat gctcagatac aggcagggac acacacccag acacccaccc agaccgtgga    960

gcaggacagc agccaccaga caggaagcac cagcacccag acacaggagt ccaccaatgg   1020

ccagaacaga gggactgaga tccacggtca aggcaggagc cagaccagcc aggctgtgac   1080

aggaggacac actcagatac aggcagggtc acacaccgag actgtggagc aggacagaag   1140

ccaaactgta agccacggag gggctagaga acagggacag acccagacgc agccaggcag   1200

tggtcaaaga tggatgcaag tgagcaaccc tgaggcagga gagacagtac cgggaggaca   1260

ggcccagact ggggcaagca ctgagtcagg aaggcaggag tggagcagca ctcacccaag   1320

gcgctgtgtg acagaagggc agggagacag acagcccaca gtggttggtg aggaatgggt   1380

tgatgaccac tcaagggaga cagtgatcct caggctggac cagggcaact tgcataccag   1440

tgtttcctca gcacagggcc aggatgcagc ccagtcagaa gagaagcgag gcatcacagc   1500

tagagagctg tattcctact tgagaagcac caagccatga cttccccgac tccaatgtcc   1560

agtactggaa gaagacagct ggagagagtt tggcttgtcc tgcatggcca atccagtggg   1620

tgcatccctg gacatcagct cttcattatg cagcttccct tttaggtctt tctcaatgag   1680

ataatttctg caaggagctt tctatcctga actcttcttt cttacctgct ttgcggtgca   1740

gaccctctca ggagcaggaa gactcagagc aagtcacccc tttgtactga attgtcctca   1800

tcttgtgggg ggtttcagga ctatttttat ctctgacatc tctctattgc cccatctacc   1860

ctaatgcatc aataaaacct taagccgctg g                                  1891


<210>  284
<211>  495
<212>  PRT
<213>  Homosapiens

<400>  284

Met Pro Gln Leu Leu Gln Asn Ile Asn Gly Ile Ile Glu Ala Phe Arg 
1               5                   10                  15      


Arg Tyr Ala Arg Thr Glu Gly Asn Cys Thr Ala Leu Thr Arg Gly Glu 
            20                  25                  30          


Leu Lys Arg Leu Leu Glu Gln Glu Phe Ala Asp Val Ile Val Lys Pro 
        35                  40                  45              


His Asp Pro Ala Thr Val Asp Glu Val Leu Arg Leu Leu Asp Glu Asp 
    50                  55                  60                  


His Thr Gly Thr Val Glu Phe Lys Glu Phe Leu Val Leu Val Phe Lys 
65                  70                  75                  80  


Val Ala Gln Ala Cys Phe Lys Thr Leu Ser Glu Ser Ala Glu Gly Ala 
                85                  90                  95      


Cys Gly Ser Gln Glu Ser Gly Ser Leu His Ser Gly Ala Ser Gln Glu 
            100                 105                 110         


Leu Gly Glu Gly Gln Arg Ser Gly Thr Glu Val Gly Arg Ala Gly Lys 
        115                 120                 125             


Gly Gln His Tyr Glu Gly Ser Ser His Arg Gln Ser Gln Gln Gly Ser 
    130                 135                 140                 


Arg Gly Gln Asn Arg Pro Gly Val Gln Thr Gln Gly Gln Ala Thr Gly 
145                 150                 155                 160 


Ser Ala Trp Val Ser Ser Tyr Asp Arg Gln Ala Glu Ser Gln Ser Gln 
                165                 170                 175     


Glu Arg Ile Ser Pro Gln Ile Gln Leu Ser Gly Gln Thr Glu Gln Thr 
            180                 185                 190         


Gln Lys Ala Gly Glu Gly Lys Arg Asn Gln Thr Thr Glu Met Arg Pro 
        195                 200                 205             


Glu Arg Gln Pro Gln Thr Arg Glu Gln Asp Arg Ala His Gln Thr Gly 
    210                 215                 220                 


Glu Thr Val Thr Gly Ser Gly Thr Gln Thr Gln Ala Gly Ala Thr Gln 
225                 230                 235                 240 


Thr Val Glu Gln Asp Ser Ser His Gln Thr Gly Arg Thr Ser Lys Gln 
                245                 250                 255     


Thr Gln Glu Ala Thr Asn Asp Gln Asn Arg Gly Thr Glu Thr His Gly 
            260                 265                 270         


Gln Gly Arg Ser Gln Thr Ser Gln Ala Val Thr Gly Gly His Ala Gln 
        275                 280                 285             


Ile Gln Ala Gly Thr His Thr Gln Thr Pro Thr Gln Thr Val Glu Gln 
    290                 295                 300                 


Asp Ser Ser His Gln Thr Gly Ser Thr Ser Thr Gln Thr Gln Glu Ser 
305                 310                 315                 320 


Thr Asn Gly Gln Asn Arg Gly Thr Glu Ile His Gly Gln Gly Arg Ser 
                325                 330                 335     


Gln Thr Ser Gln Ala Val Thr Gly Gly His Thr Gln Ile Gln Ala Gly 
            340                 345                 350         


Ser His Thr Glu Thr Val Glu Gln Asp Arg Ser Gln Thr Val Ser His 
        355                 360                 365             


Gly Gly Ala Arg Glu Gln Gly Gln Thr Gln Thr Gln Pro Gly Ser Gly 
    370                 375                 380                 


Gln Arg Trp Met Gln Val Ser Asn Pro Glu Ala Gly Glu Thr Val Pro 
385                 390                 395                 400 


Gly Gly Gln Ala Gln Thr Gly Ala Ser Thr Glu Ser Gly Arg Gln Glu 
                405                 410                 415     


Trp Ser Ser Thr His Pro Arg Arg Cys Val Thr Glu Gly Gln Gly Asp 
            420                 425                 430         


Arg Gln Pro Thr Val Val Gly Glu Glu Trp Val Asp Asp His Ser Arg 
        435                 440                 445             


Glu Thr Val Ile Leu Arg Leu Asp Gln Gly Asn Leu His Thr Ser Val 
    450                 455                 460                 


Ser Ser Ala Gln Gly Gln Asp Ala Ala Gln Ser Glu Glu Lys Arg Gly 
465                 470                 475                 480 


Ile Thr Ala Arg Glu Leu Tyr Ser Tyr Leu Arg Ser Thr Lys Pro 
                485                 490                 495 


<210>  285
<211>  835
<212>  DNA
<213>  Homosapiens

<400>  285
caggtagagt gcttctcagg accaggatga actcttggtg ctggtgtttt gggcagaaag     60

agcccctggg tggaggttga ggccattctt gaagaaagac aaggataaag aaggattttg    120

gaggggaagg ttcttctgga aggggagggt ggaagcttta ttcagcttct acagagatgt    180

cctgccagca gagccagcag cagtgccagc ctcctcccaa atgtacccct aaatgccctc    240

ccaagtgtac tcctaagtgt cctcccaagt gtcccccaaa atgccctccc cagtgttcag    300

ccccatgccc acctccagtc tcttcctgct gtggttccag ctctgggggc tgctgcagct    360

ctgagggtgg tggctgctgc ctgagccacc acaggccccg ccagtccctc cgacgccgac    420

ctcagagttc cagctgctgt ggcagtggca gtggccagca gtctgggggc tccagctgct    480

gccacagctc tgggggctct ggctgctgcc acagctctgg aggctgctgc tgacctgggc    540

catgaggagc acggaggaga aggactggca gatcccaggt gctgaagatg tgtgtcagcc    600

tgaggcttct tttctctcat ttcccatgga aggacttcgg aaatgcctta agttcccctc    660

tttatcctgc tcatgttcac tccattgtag ggttgaagtc tagcttgtga tattttctgg    720

cctggctttc cctctcagac atagctcttt ggagaactag gtgttgtaat tcagttatga    780

agctattttc tctgtaacaa taaagctttt tattcctgaa aaaaaaaaaa aaaaa         835


<210>  286
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  286

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Pro Pro Lys Cys Thr Pro Lys Cys Pro Pro Lys Cys 
            20                  25                  30          


Pro Pro Lys Cys Pro Pro Gln Cys Ser Ala Pro Cys Pro Pro Pro Val 
        35                  40                  45              


Ser Ser Cys Cys Gly Ser Ser Ser Gly Gly Cys Cys Ser Ser Glu Gly 
    50                  55                  60                  


Gly Gly Cys Cys Leu Ser His His Arg Pro Arg Gln Ser Leu Arg Arg 
65                  70                  75                  80  


Arg Pro Gln Ser Ser Ser Cys Cys Gly Ser Gly Ser Gly Gln Gln Ser 
                85                  90                  95      


Gly Gly Ser Ser Cys Cys His Ser Ser Gly Gly Ser Gly Cys Cys His 
            100                 105                 110         


Ser Ser Gly Gly Cys Cys 
        115             


<210>  287
<211>  699
<212>  DNA
<213>  Homosapiens

<400>  287
gcccattcca gttggagaac gtagtgagtc tttcagtgga gccagggtct ggtttgtcgt     60

gaggagctcc gcgatgtcct ctcaacagag cgccgtttcc gccaaaggct tttccaaggg    120

gtcgtcccag ggccccgctc cgtgtcccgc cccggcgccc accccggcgc ccgcctcctc    180

ctcctcctgc tgtggctccg gcaggggctg ctgcggcgac tcaggctgct gcggctccag    240

ctccaccagt tgctgctgct tcccaaggag acgccgtcga cagcggagta gtggttgctg    300

ctgctgcggg ggcggcagcc agaggtccca gcgctccaac aaccggagct caggatgctg    360

ctccggctgc tgagaggccc gcaaccccca gcgctgcgct agagaaaccc gcccagccca    420

gagcgggccc gccccgctgc ggctcccacg cggggctggg cctcggagtt tgccccgtaa    480

agcgaattgc actttgatgt tcagaaaccc actttgttct cagccacgca aaactccctg    540

accccgatgt gatttttctc cccggggatt cgagagccat gcgtgggaca ctggacccta    600

ctgtctacac gggcttgcac acagcaggtg ctcagcaaat gcctattgat ttgattgtct    660

tttgaagatg tcataataaa gcttctacct cctgaaaaa                           699


<210>  288
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  288

Met Ser Ser Gln Gln Ser Ala Val Ser Ala Lys Gly Phe Ser Lys Gly 
1               5                   10                  15      


Ser Ser Gln Gly Pro Ala Pro Cys Pro Ala Pro Ala Pro Thr Pro Ala 
            20                  25                  30          


Pro Ala Ser Ser Ser Ser Cys Cys Gly Ser Gly Arg Gly Cys Cys Gly 
        35                  40                  45              


Asp Ser Gly Cys Cys Gly Ser Ser Ser Thr Ser Cys Cys Cys Phe Pro 
    50                  55                  60                  


Arg Arg Arg Arg Arg Gln Arg Ser Ser Gly Cys Cys Cys Cys Gly Gly 
65                  70                  75                  80  


Gly Ser Gln Arg Ser Gln Arg Ser Asn Asn Arg Ser Ser Gly Cys Cys 
                85                  90                  95      


Ser Gly Cys 
            


<210>  289
<211>  611
<212>  DNA
<213>  Homosapiens

<400>  289
ctcaggaaca gccttctcct gcctctctgc acctggacat ctcaactcct gccaagatgt     60

cctgccagca gaaccagaag cagtgccaac ccccacccaa gtgcccctca cccaagtgtc    120

ccccaaagaa cccagtacag tgtctgcctc cagcttcctc tggctgtgcc ccaagctctg    180

ggggctgtgg ccctagctcc gagggcggct gcttcctgaa ccaccacagg cgccaccacc    240

gatgccggcg ccagaggtcc aactcctgtg acaggggcag tggtcagcaa ggcgggggct    300

ctggctgctg ccacggttct gggggctgct gctgatccag atcctgatgc tgagacaagc    360

gatctttgga ggaaacaaga atcccaagag gccaagaaca gccccatctg acgcatgcct    420

tcccatatac cctcttctga ctttcacagg ctgagctgga ggttttcctg tgggggatct    480

gagctctccc cagaaggcac ttcttgtttt atgtacagga tgtcatatgt ccccctaccc    540

ctgtacctgc caaggattgg cagtgcttgt gcccaacctc gtaaaaaaga taaagttcct    600

tgtcctcatt a                                                         611


<210>  290
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  290

Met Ser Cys Gln Gln Asn Gln Lys Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Ser Pro Lys Cys Pro Pro Lys Asn Pro Val Gln Cys Leu Pro Pro 
            20                  25                  30          


Ala Ser Ser Gly Cys Ala Pro Ser Ser Gly Gly Cys Gly Pro Ser Ser 
        35                  40                  45              


Glu Gly Gly Cys Phe Leu Asn His His Arg Arg His His Arg Cys Arg 
    50                  55                  60                  


Arg Gln Arg Ser Asn Ser Cys Asp Arg Gly Ser Gly Gln Gln Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Cys Cys His Gly Ser Gly Gly Cys Cys 
                85                  90          


<210>  291
<211>  617
<212>  DNA
<213>  Homosapiens

<400>  291
ctcaggaaca gccttctcct gcctcctctg cacctggaca actcaactcc tgccaagatg     60

tcctgccagc agaaccagca gcagtgccaa cccccaccca agtgtccctc acccaagtgt    120

cccccaaaga gcccagtaca gtgtctgcct ccagcttcct ctggctgtgc cccaagctct    180

gggggctgtg gccctagctc cgagggcggc tgcttcctga accaccacag gcgccaccac    240

cgatgccggc gccagaggcc caactcctgt gacaggggca gtggtcagca aggcgggggc    300

tctggctgcg gccatggctc tggaggctgc tgctgacctg gatcctgatg ctgagacaag    360

cgattttgga ggaaacaaga atcccaaggg cccaggaaaa ccccatcttg atgcatgagt    420

tcccagatac cctcttctgg ctttcacagg ctgagctagg ggttttcctg tggaaggtct    480

gagctctccc cagaaggcac ttcctgtctg atgtccagga tgtcacatgt tcccttaccc    540

ctgtacctgt gaaggattgg cagtgcttgt gcctgacctc atcaaaaaat aaagctcctt    600

gtcctcatta aaaaaaa                                                   617


<210>  292
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  292

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Ser Pro Lys Cys Pro Pro Lys Ser Pro Val Gln Cys Leu Pro Pro 
            20                  25                  30          


Ala Ser Ser Gly Cys Ala Pro Ser Ser Gly Gly Cys Gly Pro Ser Ser 
        35                  40                  45              


Glu Gly Gly Cys Phe Leu Asn His His Arg Arg His His Arg Cys Arg 
    50                  55                  60                  


Arg Gln Arg Pro Asn Ser Cys Asp Arg Gly Ser Gly Gln Gln Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Cys Gly His Gly Ser Gly Gly Cys Cys 
                85                  90          


<210>  293
<211>  285
<212>  DNA
<213>  Homosapiens

<400>  293
atgtcctgcc agcaaaacca gcagcagtgc cagccccctc ccagttgtcc ctcacccaag     60

tgtcccccaa agagcccagc acagtgtctg cctccaccct cttctgactg tgctctaagc    120

tccgggggct gtggccccag ttctgaaagt ggctgctgcc tgagccacca caggcacttc    180

aggtcccatc aatgccggcg ccagagatcc aactcctgtg acaggggcag tggtcagcaa    240

ggcgggggct cctgccgtgg ccatggctct gggggctgct gctga                    285


<210>  294
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  294

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Ser Cys 
1               5                   10                  15      


Pro Ser Pro Lys Cys Pro Pro Lys Ser Pro Ala Gln Cys Leu Pro Pro 
            20                  25                  30          


Pro Ser Ser Asp Cys Ala Leu Ser Ser Gly Gly Cys Gly Pro Ser Ser 
        35                  40                  45              


Glu Ser Gly Cys Cys Leu Ser His His Arg His Phe Arg Ser His Gln 
    50                  55                  60                  


Cys Arg Arg Gln Arg Ser Asn Ser Cys Asp Arg Gly Ser Gly Gln Gln 
65                  70                  75                  80  


Gly Gly Gly Ser Cys Arg Gly His Gly Ser Gly Gly Cys Cys 
                85                  90                  


<210>  295
<211>  288
<212>  DNA
<213>  Homosapiens

<400>  295
atgtcctgcc agcagaacca gcagcagtgc cagcctctgc ccaagtgccc ctcacccaag     60

tgccccccaa agagctcagc acagtgtctg cctccagcct cctcctgctg tgctccaaga    120

cctgggtgct gtggtggccc cagctctgag ggcggctgct gcctgagcca ccacaggtgc    180

tgcaggtccc accgatgccg gcgccagagc tccaactcct gtgacagagg cagtggtcag    240

caagatggtg cctccgactg tggctatggc tctggaggct gctgctga                 288


<210>  296
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  296

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Leu Pro Lys Cys 
1               5                   10                  15      


Pro Ser Pro Lys Cys Pro Pro Lys Ser Ser Ala Gln Cys Leu Pro Pro 
            20                  25                  30          


Ala Ser Ser Cys Cys Ala Pro Arg Pro Gly Cys Cys Gly Gly Pro Ser 
        35                  40                  45              


Ser Glu Gly Gly Cys Cys Leu Ser His His Arg Cys Cys Arg Ser His 
    50                  55                  60                  


Arg Cys Arg Arg Gln Ser Ser Asn Ser Cys Asp Arg Gly Ser Gly Gln 
65                  70                  75                  80  


Gln Asp Gly Ala Ser Asp Cys Gly Tyr Gly Ser Gly Gly Cys Cys 
                85                  90                  95  


<210>  297
<211>  270
<212>  DNA
<213>  Homosapiens

<400>  297
atgtcctgcc agcagaacca gcagcagtgc cagcctccgc ccaagtgccc tgcaaagagc     60

ccagcacagt gtctgcctcc agcttcctcc agctgtgccc caagctctgg gggctgtggg    120

cccagctccg agcgcagctg ctgcctgagt caccacagat gccgcaggtc tcaccgttgc    180

cgttgccaga gctccaactc ctgtgacagg ggaagtggtc agcaaggcgg gagctccagc    240

tgtggccaca gttctgcggg ctgctgctga                                     270


<210>  298
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  298

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Ala Lys Ser Pro Ala Gln Cys Leu Pro Pro Ala Ser Ser Ser Cys 
            20                  25                  30          


Ala Pro Ser Ser Gly Gly Cys Gly Pro Ser Ser Glu Arg Ser Cys Cys 
        35                  40                  45              


Leu Ser His His Arg Cys Arg Arg Ser His Arg Cys Arg Cys Gln Ser 
    50                  55                  60                  


Ser Asn Ser Cys Asp Arg Gly Ser Gly Gln Gln Gly Gly Ser Ser Ser 
65                  70                  75                  80  


Cys Gly His Ser Ser Ala Gly Cys Cys 
                85                  


<210>  299
<211>  609
<212>  DNA
<213>  Homosapiens

<400>  299
cagggacgtg tctgtgcttt tgcatgtgac cagggttgac taaactcctg ccaggatgtc     60

ttgccagcaa aaccagcagc agtgccagcc ccctcccaaa tgtcctccca agtgtacccc    120

aaaatgtcca cctaagtgtc cccccaaatg cccaccacag tgcccagctc catgttcccc    180

tgcagtctct tcctgctgtg gtcccagctc tgggagctgc tgtggtccca gctctggggg    240

ctgctgcagc tctgggggtg gtggctgctg cctgagccac cacaggcccc gtctcttcca    300

ccggcgccgg caccagagcc ccgattgctg tgagagtgaa ccttctgggg cctctggctg    360

ctgccacagc tctgggggct gctgctgacc tgggctgcag aagagctctg gtactgaatg    420

gtcaaaaacc tgctacagcc tgatgcttaa ctatttcccc ttcctttcat tccactcatg    480

ggtggacagg gaccacaaag actcatgggg cttccccaga actttgtgct tgatggagca    540

ccccagatgg aagccttctt tttctccttt acctcatatt gtaataaagc tctgatttct    600

gactcttta                                                            609


<210>  300
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  300

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Pro Lys Cys Thr Pro Lys Cys Pro Pro Lys Cys Pro Pro Lys Cys 
            20                  25                  30          


Pro Pro Gln Cys Pro Ala Pro Cys Ser Pro Ala Val Ser Ser Cys Cys 
        35                  40                  45              


Gly Pro Ser Ser Gly Ser Cys Cys Gly Pro Ser Ser Gly Gly Cys Cys 
    50                  55                  60                  


Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser His His Arg Pro Arg Leu 
65                  70                  75                  80  


Phe His Arg Arg Arg His Gln Ser Pro Asp Cys Cys Glu Ser Glu Pro 
                85                  90                  95      


Ser Gly Ala Ser Gly Cys Cys His Ser Ser Gly Gly Cys Cys 
            100                 105                 110 


<210>  301
<211>  614
<212>  DNA
<213>  Homosapiens

<400>  301
cagggacgtg tctgtgctcc tgcgtgtgac cagggttgac taaactcctg ccagcatgtc     60

ttgccagcaa aaccagcagc agtgccagcc ccctcccaag tgtcctccca agtgtacccc    120

aaaatgtcca cctaagtgtc cccccaaatg cccaccacag tgcccagctc catgtttccc    180

tgcagtctct tcttgctgtg gtcccagctc tgggagctgc tgtggtccca gctctggggg    240

ctgctgcagc tctggggctg gtggctgctc cctgagccac cacaggcccc gtctcttcca    300

ccggcgccgg caccagagcc ccgactgctg tgagagtgaa ccttctgggg gctctggctg    360

ctgccacagc tctgggggct gctgctgacc tgggctacag aagagctctt gggactgaat    420

ggccaagaac ctgctacggc ctgatggata ctctttccac ttcctctcat tccattcatt    480

ggttggcaga gaccacaaag actcatgggg ctttcctgga agaacttcgt gcttgatgta    540

acaccccaat tgcaagtctt cttttcctcc tttacctcat gttataataa agctctgatc    600

tctgactcac taaa                                                      614


<210>  302
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  302

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Pro Lys Cys Thr Pro Lys Cys Pro Pro Lys Cys Pro Pro Lys Cys 
            20                  25                  30          


Pro Pro Gln Cys Pro Ala Pro Cys Phe Pro Ala Val Ser Ser Cys Cys 
        35                  40                  45              


Gly Pro Ser Ser Gly Ser Cys Cys Gly Pro Ser Ser Gly Gly Cys Cys 
    50                  55                  60                  


Ser Ser Gly Ala Gly Gly Cys Ser Leu Ser His His Arg Pro Arg Leu 
65                  70                  75                  80  


Phe His Arg Arg Arg His Gln Ser Pro Asp Cys Cys Glu Ser Glu Pro 
                85                  90                  95      


Ser Gly Gly Ser Gly Cys Cys His Ser Ser Gly Gly Cys Cys 
            100                 105                 110 


<210>  303
<211>  619
<212>  DNA
<213>  Homosapiens

<400>  303
cagggacgtg tctgtgctcc tgcgtgtgac cagggttgac taaactctgc caggatgtct     60

tgccagcaaa accagcagca gtgccagccc cctcccaagt gtcctcccaa gtgtacccca    120

aaatgtccac ctaagtgtcc ccctaaatgc ctgccccagt gcccagctcc atgttcccct    180

gcagtctctt cttgctgtgg tcccatctct gggggctgct gtggtcccag ctctgggggc    240

tgctgcaact ctggggctgg tggctgctgc ctgagccacc acaggccccg tctcttccac    300

cggcgccggc accagagccc cgactgctgt gagagtgaac cttctggggg ctctggctgc    360

tgccacagct ctgggggctg ctgctgacct gggctaagaa gaactctttg gacagaatgt    420

ttaagaacct cctacagcct gatgcttaac cctttccatt tcctctcatt ccattcatgg    480

gtggacagcg accacaaaga ctcatggggc ttccctggga gaactttgca cttgatggaa    540

cacctcaatt gcaggttttg ttttcctcct ttacctcatg ttgtaataaa gctctgattt    600

ctgactcaca aaaaaaaaa                                                 619


<210>  304
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  304

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Pro Lys Cys Thr Pro Lys Cys Pro Pro Lys Cys Pro Pro Lys Cys 
            20                  25                  30          


Leu Pro Gln Cys Pro Ala Pro Cys Ser Pro Ala Val Ser Ser Cys Cys 
        35                  40                  45              


Gly Pro Ile Ser Gly Gly Cys Cys Gly Pro Ser Ser Gly Gly Cys Cys 
    50                  55                  60                  


Asn Ser Gly Ala Gly Gly Cys Cys Leu Ser His His Arg Pro Arg Leu 
65                  70                  75                  80  


Phe His Arg Arg Arg His Gln Ser Pro Asp Cys Cys Glu Ser Glu Pro 
                85                  90                  95      


Ser Gly Gly Ser Gly Cys Cys His Ser Ser Gly Gly Cys Cys 
            100                 105                 110 


<210>  305
<211>  592
<212>  DNA
<213>  Homosapiens

<400>  305
ggacgtgtct gtgctcctgt gtgtgaccag ggttgaaaaa gtcgcactga gatgtcctgc     60

cagcaaaacc agcagcagtg ccagccccct cccaagtgcc ccccaaaatg cccacccaag    120

tgtcctccaa agtgccgacc tcagtgccca gccccatgcc cacctccagt ctcttcctgc    180

tgtggtccca gctctggggg ctgctgcggc tccagctctg ggggctgctg cagctctggg    240

ggtggcggct gctgcctgag ccaccacagg ccccgtctct tccaccggca ccggcaccag    300

agccccgatt gttgtgagtg tgaaccttct gggggctctg gctgctgcca cagctctggg    360

gactgctgct gaccagacct cgaacatcac agagcaaccc ttatggagaa acttgcaacc    420

aggacctgtc ccagagtgat gcttctcctg cccctttttc tcctttcctt gggctgacac    480

accttgtgag gtgttttgtc tgttgtcatg gcccaagagc ccatcctgga tcctgatctt    540

accttcccac tttacctcat acaacaataa agctcttttg cctcttcgtg aa            592


<210>  306
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  306

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Pro Lys Cys Pro Pro Lys Cys Pro Pro Lys Cys Arg Pro Gln Cys 
            20                  25                  30          


Pro Ala Pro Cys Pro Pro Pro Val Ser Ser Cys Cys Gly Pro Ser Ser 
        35                  40                  45              


Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Cys Cys Ser Ser Gly Gly 
    50                  55                  60                  


Gly Gly Cys Cys Leu Ser His His Arg Pro Arg Leu Phe His Arg His 
65                  70                  75                  80  


Arg His Gln Ser Pro Asp Cys Cys Glu Cys Glu Pro Ser Gly Gly Ser 
                85                  90                  95      


Gly Cys Cys His Ser Ser Gly Asp Cys Cys 
            100                 105     


<210>  307
<211>  300
<212>  DNA
<213>  Homosapiens

<400>  307
atgtcctgcc agcagaacca acagcagtgc cagccccctc ccaagtgtcc tatccccaag     60

tatcccccaa aatgtccctc aaagtgtgca tcctcatgcc cacctccaat ctcttcctgc    120

tgtggctcca gctctggggg ctgtggttgc tgcagctctg agggaggtgg ctgctgcctg    180

agccaccaca gacaccatag gtcccactgc cacagaccca agagctccaa ttgctatggc    240

agtggcagtg gccagcagtc tgggggttct ggctgctgct ctggaggggg ctgttgctga    300


<210>  308
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  308

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Ile Pro Lys Tyr Pro Pro Lys Cys Pro Ser Lys Cys Ala Ser Ser 
            20                  25                  30          


Cys Pro Pro Pro Ile Ser Ser Cys Cys Gly Ser Ser Ser Gly Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Ser Glu Gly Gly Gly Cys Cys Leu Ser His His Arg 
    50                  55                  60                  


His His Arg Ser His Cys His Arg Pro Lys Ser Ser Asn Cys Tyr Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Gln Gln Ser Gly Gly Ser Gly Cys Cys Ser Gly Gly 
                85                  90                  95      


Gly Cys Cys 
            


<210>  309
<211>  357
<212>  DNA
<213>  Homosapiens

<400>  309
atgtcttgcc agcagagcca gcagcagtgc cagccccctc ccaagtgcac tcccaagtgc     60

cctcccaagt gccccacacc gaagtgcccc ccaaagtgtc cccctaagtg ccctcctgtc    120

tcttcctgct gcagcgtcag ctccggaggc tgctgtggct ccagctctgg gggctgctgc    180

agctctgggg gtggtggctg ctgcagctct gggggaggcg gctgttgcct gagccaccac    240

agacggcgta ggtcccaccg ccacagaccc cagagctctg actgctgcag ccagccctca    300

gcgggctcca gctgctgcgg agggggcagt ggccagcact ctggaggctg ctgctga       357


<210>  310
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  310

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Pro Pro Lys Cys Pro Thr Pro Lys Cys Pro Pro Lys 
            20                  25                  30          


Cys Pro Pro Lys Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser 
        35                  40                  45              


Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Cys Cys Ser Ser Gly Gly 
    50                  55                  60                  


Gly Gly Cys Cys Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser His His 
65                  70                  75                  80  


Arg Arg Arg Arg Ser His Arg His Arg Pro Gln Ser Ser Asp Cys Cys 
                85                  90                  95      


Ser Gln Pro Ser Ala Gly Ser Ser Cys Cys Gly Gly Gly Ser Gly Gln 
            100                 105                 110         


His Ser Gly Gly Cys Cys 
        115             


<210>  311
<211>  1210
<212>  DNA
<213>  Homosapiens

<400>  311
gccgaaggac cctgtgctgc ctgtgacttt gctcctaagt acctactgcc gagatgtcct     60

gccagcagag ccagcagcag tgccagcccc ctcccaagtg cactcccaag tgccctccca    120

agtgtcccac ccccaaatgc cctccaaagt gtccccctaa gtgccctcca gtctcttcct    180

gctgcagtgt cagctccgga ggctgctgtg gctccagctc tgggggcagc tgtggctcca    240

gctctggggg ctgctgcagc tctgggggag gtggctgctg cctgagccac cacaggcacc    300

acaggtccca ccgtcacaga ccccagagct ctgactgctg cagccagccc tcagggggct    360

ccagctgctg tggagggggc agcggccagc actctggagg ctgctgctga agtggacctt    420

gacttcctct tccttctgat tctgcctgaa tagctgagag gttccagcaa aagcttgaag    480

tcttgcctgg agaatccctc tgctctggtg tcaggaaacc caaaatcttt ctccttaatg    540

gcatttagag actttcttct gcagatccat ggctgccctg ggaactccaa agcacacacc    600

tacttcctcc ccagctcacg ctgctgtatt ctgtgctgcc tgaactgaag aaataaaatc    660

cagaatctgc cccccaactt gctaccagcc tgcttgattt tcctgtttgt gtcatccttg    720

ttctgctccc ctgtgtctgc tggtggctgc tgaggccttg gtggacagag gatggggaaa    780

ggggtcagga ggaaaaagct tgcatttctg tgtgttttgt gttttttctt ctttcggtgt    840

tttcctttta aaccaaggga ctgaaatagc attgagaaat atttttcttt caaattctgg    900

ttcctttcac ctatgtaacc gcatccctca ggcatggcca ggaggccgac ttcatcctcc    960

ttcccactat cacctcttca ttcttgtgtt cctcgttccc cactccttcc actaacaatc   1020

tccctggact cctcctccat actgtatgtg catgcattca cacacacata tgtacatgca   1080

catagatgag atgaatctgc attgtaaaaa aattaaatca catttagtgc tgtataattt   1140

gcatgcaata aaattcaata aaattaaatg taaaattaaa aaaaaaaaaa aaaaaaaaaa   1200

aaaaaaaaaa                                                          1210


<210>  312
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  312

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Pro Pro Lys Cys Pro Thr Pro Lys Cys Pro Pro Lys 
            20                  25                  30          


Cys Pro Pro Lys Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser 
        35                  40                  45              


Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Ser Cys Gly Ser Ser Ser 
    50                  55                  60                  


Gly Gly Cys Cys Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser His His 
65                  70                  75                  80  


Arg His His Arg Ser His Arg His Arg Pro Gln Ser Ser Asp Cys Cys 
                85                  90                  95      


Ser Gln Pro Ser Gly Gly Ser Ser Cys Cys Gly Gly Gly Ser Gly Gln 
            100                 105                 110         


His Ser Gly Gly Cys Cys 
        115             


<210>  313
<211>  345
<212>  DNA
<213>  Homosapiens

<400>  313
atgtcctgcc agcagagcca gcagcagtgc cagccccctc ccaagtgcac tcccaagtgc     60

actcccaagt gccccgcccc taaatgtccc cctaagtgcc ctccagtctc ttcctgctgc    120

agtgtcagct ccggaggctg ctgtggctcc agctctgggg gcggctgtgg ctccaactct    180

gggggctgct gcagctctgg gggtggtggc tgctgcctga gccaccacag gcgccacagg    240

tcccaccgtc gcagacccca gagctctgac tgctgcagcc agccctcggg gggctccagc    300

tgctgcggtg ggggcagcag ccagcactct ggaggctgct gctga                    345


<210>  314
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  314

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Thr Pro Lys Cys Pro Ala Pro Lys Cys Pro Pro Lys 
            20                  25                  30          


Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser Gly Gly Cys Cys 
        35                  40                  45              


Gly Ser Ser Ser Gly Gly Gly Cys Gly Ser Asn Ser Gly Gly Cys Cys 
    50                  55                  60                  


Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser His His Arg Arg His Arg 
65                  70                  75                  80  


Ser His Arg Arg Arg Pro Gln Ser Ser Asp Cys Cys Ser Gln Pro Ser 
                85                  90                  95      


Gly Gly Ser Ser Cys Cys Gly Gly Gly Ser Ser Gln His Ser Gly Gly 
            100                 105                 110         


Cys Cys 
        


<210>  315
<211>  695
<212>  DNA
<213>  Homosapiens

<400>  315
gctgaaggac cctgtgctgc ctgtgacccc gctcctgaat ccgccaccaa gatgtcctgc     60

cagcagagcc agcagcagtg ccagccccct cccaagtgca cccccaagtg ccctcccaag    120

tgccccaccc caaagtgtcc cccaaagtgt ccccctaagt gccctcctgt ctcttcctgc    180

tgcagtgtca gctccggagg ctgctgtggc tccagctctg ggggcagctg tggctccagc    240

tctgggggat gctgcagttc tgggggaggt ggctgctgcc tgagccacca caggcgccgt    300

aggtcccact gccacagacc ccagagctct ggctgctgca gccagccctc ggggggctcc    360

agctgctgtg gcggggggag tggccagcac tctggaggct gctgctgaag tggaccctga    420

gcctagaaga gcagaatcca ggaccgcaaa ctgccaagga catccccctt ctcctactag    480

gcctgcctga gaggctcaca ggtccaaggg aaagctctga acttgccaag agcatatctt    540

ttccctggag tccagaaact cagatcctct cctggatctc cattcactgg ccttggacct    600

cacctttgtg gctaccctcc cacgctctgt ctaagcccct agcttactca atgtcatttg    660

cagcgtgcat ctgctgatta aaggactaaa acaag                               695


<210>  316
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  316

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Pro Pro Lys Cys Pro Thr Pro Lys Cys Pro Pro Lys 
            20                  25                  30          


Cys Pro Pro Lys Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser 
        35                  40                  45              


Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Ser Cys Gly Ser Ser Ser 
    50                  55                  60                  


Gly Gly Cys Cys Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser His His 
65                  70                  75                  80  


Arg Arg Arg Arg Ser His Cys His Arg Pro Gln Ser Ser Gly Cys Cys 
                85                  90                  95      


Ser Gln Pro Ser Gly Gly Ser Ser Cys Cys Gly Gly Gly Ser Gly Gln 
            100                 105                 110         


His Ser Gly Gly Cys Cys 
        115             


<210>  317
<211>  1197
<212>  DNA
<213>  Homosapiens

<400>  317
gttctgaact tctatgtcct tacaacaagg taatctagaa aattcttcca agagagaatg     60

actgtttccc cttgagaaac aattttattt ccaaacccct ttctagattg ttttcatgat    120

tcaggtgtgt agttgaagca gaatgtctcc tctacatact acatgcttga ttttgagaat    180

actttcttaa tatcttttgg cttcggtttt ctaattataa aatagttgaa aatgctttat    240

gattttataa gtatataaaa agcattaggt tcaaaacaga ggctataagt gtgtttagcc    300

aactattaga cacaatgaaa cttcccgtga ttaattagct acaactacac taagcagttc    360

atcaaaatgt agggattaga aatgatgctg aaagggcaag aataggccgg ggtggcctct    420

acctgggtct aacttgctgt ctgactctct ctcagctcct gaacacccgc accaagatgt    480

cctgccagca gaaccagcag cagtgccagc cccctcccaa gtgcatcccc aagtgccctc    540

ccaagtgcct cacccctaga tgccccccaa agtgtccccc taagtgtcct ccagtctctt    600

cctgctgcag tgtcagctcc ggaggctgct gtggctccag ctctggggga agctgtggct    660

ccagctctgg gggttgctgc agttctgggg gaggtggctg ctgcctgagc caccacaggc    720

gccgtaggtc ccactgccac agaccccaga gctctggctg ctgcagccag ccctccgggg    780

gctccagctg ctgtggagga gggagtggcc agcactctgg aggctgctgc taaagtggat    840

cctgagccta gaagaacaca aatggccaaa tatttccctt ccgtcttcct tctccttctg    900

ggcctgccca tgttgttgag aggtcttggt gagggctcaa ctcaagcata gaggattctt    960

ctgtcttgga gttcagaggc ccaaaacttc tcccccaaag ccaagccatt taatgacctc   1020

agtttgcgta tgtgtggttg ctctgggaag cccaaagcac agacctatat ccctttgcag   1080

cttgtctttt tgcatagctc agcctgatgt gaaacaataa aaccagaaat atgcattcca   1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa      1197


<210>  318
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  318

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Ile Pro Lys Cys Pro Pro Lys Cys Leu Thr Pro Arg Cys Pro Pro Lys 
            20                  25                  30          


Cys Pro Pro Lys Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser 
        35                  40                  45              


Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Ser Cys Gly Ser Ser Ser 
    50                  55                  60                  


Gly Gly Cys Cys Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser His His 
65                  70                  75                  80  


Arg Arg Arg Arg Ser His Cys His Arg Pro Gln Ser Ser Gly Cys Cys 
                85                  90                  95      


Ser Gln Pro Ser Gly Gly Ser Ser Cys Cys Gly Gly Gly Ser Gly Gln 
            100                 105                 110         


His Ser Gly Gly Cys Cys 
        115             


<210>  319
<211>  333
<212>  DNA
<213>  Homosapiens

<400>  319
atgtcctgcc agcagagcca gcagcagtgc cagccccctc ccaagtgcac ccccaagtgc     60

cctcccaagt gccccactcc taagtgcccc ccaaagtgtc cccctaagtg ccctccagtc    120

tcttcctgct gcagtgtcag ctccggaggc tgctgtggct ccagctctgg gggcggctgc    180

agctctgggg gaggtggctg ctgcctgagc caccacaggc gccacaggtc ccaccgtcac    240

agactccaga gctctggctg ctgcagccag ccctcgggag gctccagctg ctgtggaggg    300

gacagcggcc agcactctgg aggctgctgc tga                                 333


<210>  320
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  320

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Pro Pro Lys Cys Pro Thr Pro Lys Cys Pro Pro Lys 
            20                  25                  30          


Cys Pro Pro Lys Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser 
        35                  40                  45              


Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Gly Cys Ser Ser Gly Gly 
    50                  55                  60                  


Gly Gly Cys Cys Leu Ser His His Arg Arg His Arg Ser His Arg His 
65                  70                  75                  80  


Arg Leu Gln Ser Ser Gly Cys Cys Ser Gln Pro Ser Gly Gly Ser Ser 
                85                  90                  95      


Cys Cys Gly Gly Asp Ser Gly Gln His Ser Gly Gly Cys Cys 
            100                 105                 110 


<210>  321
<211>  784
<212>  DNA
<213>  Homosapiens

<400>  321
agaaggcttt ggcttctgat agtcatggac tcactaggct gctgaggaag atcaataata     60

cctactggaa tcagtcatga gaagtcaagc atggaaattg tgaattgtgt gtgtggccag    120

accagtacct ccaagtgttc agaagatgtg tgaccagaca aaacacagta aatgctgccc    180

agcaaaaggc aatcaatgct gcccaccaca gcagaaccag tgctgccagt caaaaggcaa    240

tcaatgctgc ccaccaaaac agaaccagtg ctgccagcca aaaggcagtc aatgctgccc    300

accaaaacac aatcactgct gccagccaaa acccccatgc tgcattcagg ccaggtgctg    360

tggtttggag accaagcctg aagtctcacc ccttaacatg gagtctgagc ccaactcacc    420

gcaaactcag gacaagggct gtcaaaccca gcagcagccc catagcccac aaaatgagtc    480

caggccaagc aaatgagagc agaagaagtc aaacaaagaa gaagtccctg gggccatgcc    540

tttcactttg tagggtgggg gattactgag agtcaggcta gacctgtgtt tagagaagca    600

gttttcacag tgactaccat ttccacccaa tgagaggctc ctatttccca tcatagctcc    660

ctaccctagg gaggcctcca tctggaaatg ggaggatgaa gaggctagaa tcatctttcc    720

tagtgatcct gacatttaga cagcacagaa ataaagagca ataaaaagaa aaaaaaaaaa    780

aaaa                                                                 784


<210>  322
<211>  116
<212>  PRT
<213>  Homosapiens

<400>  322

Met Cys Asp Gln Thr Lys His Ser Lys Cys Cys Pro Ala Lys Gly Asn 
1               5                   10                  15      


Gln Cys Cys Pro Pro Gln Gln Asn Gln Cys Cys Gln Ser Lys Gly Asn 
            20                  25                  30          


Gln Cys Cys Pro Pro Lys Gln Asn Gln Cys Cys Gln Pro Lys Gly Ser 
        35                  40                  45              


Gln Cys Cys Pro Pro Lys His Asn His Cys Cys Gln Pro Lys Pro Pro 
    50                  55                  60                  


Cys Cys Ile Gln Ala Arg Cys Cys Gly Leu Glu Thr Lys Pro Glu Val 
65                  70                  75                  80  


Ser Pro Leu Asn Met Glu Ser Glu Pro Asn Ser Pro Gln Thr Gln Asp 
                85                  90                  95      


Lys Gly Cys Gln Thr Gln Gln Gln Pro His Ser Pro Gln Asn Glu Ser 
            100                 105                 110         


Arg Pro Ser Lys 
        115     


<210>  323
<211>  2165
<212>  DNA
<213>  Homosapiens

<400>  323
ctctgcctca gccttactgt gagtctggtt gacagtagct tctaagatgt cccagcaaca     60

cacactgcca gtgaccctct cccctgccct cagtcaggag ctcctcaaga ctgttcctcc    120

tccagtcaat acccatcagg agcaaatgaa acagccaact ccactgcctc ccccatgcca    180

gaaggtgcct gtcgagctcc cagtggaggt cccatcaaag caagaggaaa agcacatgac    240

tgctgtaaag ggactgcctg agcaagaatg tgagcaacag cagaaggagc cacaggagca    300

ggagctgcag caacagcact gggaacagca tgaggaatat cagaaagcag aaaacccaga    360

gcagcagctt aagcaggaga aaacacaaag ggatcagcag ctaaacaaac agctggaaga    420

agagaagaag ctcttagacc agcaactgga tcaagagcta gtcaagagag atgagcaact    480

gggaatgaag aaagagcaac tgttggagct cccagagcag caggaggggc acctgaagca    540

cctagagcag caggagggac agctgaagca cccggagcag caggaggggc agctggagct    600

cccagagcag caggaggggc agctggagct cccagagcag caggaggggc agctggagct    660

cccagagcag caggaggggc agctggagct cccagagcag caggaggggc agctggagct    720

cccagagcag caggaggggc agctggagct cccacagcag caggaggggc agctggagct    780

ctctgagcag caggaggggc agctggagct ctctgagcag caggagggac agctgaagca    840

cctggagcac caggaggggc agctggaggt cccagaggag cagatggggc agctgaagta    900

cctggaacag caggaggggc agctgaagca cctggatcag caggagaagc agccagagct    960

cccagagcag cagatggggc agctgaagca cctggagcag caggaggggc agcctaagca   1020

tctggagcag caggaggggc aactggagca gctggaggag caggaggggc agctgaagca   1080

cctggagcag caggaggggc agctggagca cctggagcac caggaagggc agctggggct   1140

cccagagcag caggtgctgc agctgaagca gctagagaag cagcaggggc agccaaagca   1200

cctggaggag gaggaggggc agctgaagca cctggtgcag caggaggggc agctgaagca   1260

tctggtgcag caggaggggc agctggagca gcaggagagg caggtggagc acctggagca   1320

gcaggtgggg cagctgaagc acctagagga gcaggaggga caactgaagc atctggagca   1380

gcagcagggg cagttggagg tcccagagca gcaggtgggg cagccaaaga acctggagca   1440

ggaggagaag caactggagc tcccagagca gcaagagggc caggtgaagc acctggagaa   1500

gcaggaggca cagctggagc tcccagagca gcaggtagga cagccaaagc acctggaaca   1560

gcaggaaaag cacctagagc acccagagca gcaggacgga caactaaaac atctggagca   1620

gcaggagggg cagctgaagg acctggagca gcagaagggg cagctggagc agcctgtgtt   1680

tgccccagct ccaggccagg tccaagacat tcaaccagcc ctgcccacaa agggagaagt   1740

attgcttcct gtagagcacc agcagcagaa gcaggaggtg cagtggccac ccaaacataa   1800

ataaccaccc gcagtgtcca gaggccctca gatcgtctca tacaagggaa gagagagcca   1860

ctggctccac ttatttcggg tccgctaggt ggcccgtctc atctgtgaac ttgactctgt   1920

ccctctacat gtctctttaa tggggtgagg gtgggggaga gagggaatta ttgtccagtg   1980

ccaaccccaa tgaccccaat cccaacctca ggtgagcaga gcctctactt gagggactat   2040

tgttactata ggaatcctta cttccccagt attgaagctg aatcagtgag tgtgtacaat   2100

gatacataat aaatcctgga agtcttggga tcctaaaaaa aaaaaaaaaa aaaaaaaaaa   2160

aaaaa                                                               2165


<210>  324
<211>  585
<212>  PRT
<213>  Homosapiens

<400>  324

Met Ser Gln Gln His Thr Leu Pro Val Thr Leu Ser Pro Ala Leu Ser 
1               5                   10                  15      


Gln Glu Leu Leu Lys Thr Val Pro Pro Pro Val Asn Thr His Gln Glu 
            20                  25                  30          


Gln Met Lys Gln Pro Thr Pro Leu Pro Pro Pro Cys Gln Lys Val Pro 
        35                  40                  45              


Val Glu Leu Pro Val Glu Val Pro Ser Lys Gln Glu Glu Lys His Met 
    50                  55                  60                  


Thr Ala Val Lys Gly Leu Pro Glu Gln Glu Cys Glu Gln Gln Gln Lys 
65                  70                  75                  80  


Glu Pro Gln Glu Gln Glu Leu Gln Gln Gln His Trp Glu Gln His Glu 
                85                  90                  95      


Glu Tyr Gln Lys Ala Glu Asn Pro Glu Gln Gln Leu Lys Gln Glu Lys 
            100                 105                 110         


Thr Gln Arg Asp Gln Gln Leu Asn Lys Gln Leu Glu Glu Glu Lys Lys 
        115                 120                 125             


Leu Leu Asp Gln Gln Leu Asp Gln Glu Leu Val Lys Arg Asp Glu Gln 
    130                 135                 140                 


Leu Gly Met Lys Lys Glu Gln Leu Leu Glu Leu Pro Glu Gln Gln Glu 
145                 150                 155                 160 


Gly His Leu Lys His Leu Glu Gln Gln Glu Gly Gln Leu Lys His Pro 
                165                 170                 175     


Glu Gln Gln Glu Gly Gln Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln 
            180                 185                 190         


Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln Leu Glu Leu Pro Glu Gln 
        195                 200                 205             


Gln Glu Gly Gln Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln Leu Glu 
    210                 215                 220                 


Leu Pro Glu Gln Gln Glu Gly Gln Leu Glu Leu Pro Gln Gln Gln Glu 
225                 230                 235                 240 


Gly Gln Leu Glu Leu Ser Glu Gln Gln Glu Gly Gln Leu Glu Leu Ser 
                245                 250                 255     


Glu Gln Gln Glu Gly Gln Leu Lys His Leu Glu His Gln Glu Gly Gln 
            260                 265                 270         


Leu Glu Val Pro Glu Glu Gln Met Gly Gln Leu Lys Tyr Leu Glu Gln 
        275                 280                 285             


Gln Glu Gly Gln Leu Lys His Leu Asp Gln Gln Glu Lys Gln Pro Glu 
    290                 295                 300                 


Leu Pro Glu Gln Gln Met Gly Gln Leu Lys His Leu Glu Gln Gln Glu 
305                 310                 315                 320 


Gly Gln Pro Lys His Leu Glu Gln Gln Glu Gly Gln Leu Glu Gln Leu 
                325                 330                 335     


Glu Glu Gln Glu Gly Gln Leu Lys His Leu Glu Gln Gln Glu Gly Gln 
            340                 345                 350         


Leu Glu His Leu Glu His Gln Glu Gly Gln Leu Gly Leu Pro Glu Gln 
        355                 360                 365             


Gln Val Leu Gln Leu Lys Gln Leu Glu Lys Gln Gln Gly Gln Pro Lys 
    370                 375                 380                 


His Leu Glu Glu Glu Glu Gly Gln Leu Lys His Leu Val Gln Gln Glu 
385                 390                 395                 400 


Gly Gln Leu Lys His Leu Val Gln Gln Glu Gly Gln Leu Glu Gln Gln 
                405                 410                 415     


Glu Arg Gln Val Glu His Leu Glu Gln Gln Val Gly Gln Leu Lys His 
            420                 425                 430         


Leu Glu Glu Gln Glu Gly Gln Leu Lys His Leu Glu Gln Gln Gln Gly 
        435                 440                 445             


Gln Leu Glu Val Pro Glu Gln Gln Val Gly Gln Pro Lys Asn Leu Glu 
    450                 455                 460                 


Gln Glu Glu Lys Gln Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln Val 
465                 470                 475                 480 


Lys His Leu Glu Lys Gln Glu Ala Gln Leu Glu Leu Pro Glu Gln Gln 
                485                 490                 495     


Val Gly Gln Pro Lys His Leu Glu Gln Gln Glu Lys His Leu Glu His 
            500                 505                 510         


Pro Glu Gln Gln Asp Gly Gln Leu Lys His Leu Glu Gln Gln Glu Gly 
        515                 520                 525             


Gln Leu Lys Asp Leu Glu Gln Gln Lys Gly Gln Leu Glu Gln Pro Val 
    530                 535                 540                 


Phe Ala Pro Ala Pro Gly Gln Val Gln Asp Ile Gln Pro Ala Leu Pro 
545                 550                 555                 560 


Thr Lys Gly Glu Val Leu Leu Pro Val Glu His Gln Gln Gln Lys Gln 
                565                 570                 575     


Glu Val Gln Trp Pro Pro Lys His Lys 
            580                 585 


<210>  325
<211>  766
<212>  DNA
<213>  Homosapiens

<400>  325
aagggctcag cctcctctcc tggggtccag cttgtcgcct ctggctcacc tgttcctaga     60

gcaatgtctt cccagcagca gcagcggcag cagcagcagt gcccacccca gagggcccag    120

cagcagcaag tgaagcagcc ttgtcagcca ccccctgtta aatgtcaaga gacatgtgca    180

cccaaaacca aggatccatg tgctccccag gtcaagaagc aatgcccacc gaaaggcacc    240

atcattccag cccagcagaa gtgtccctca gcccagcaag cctccaagag taaacagaag    300

taaggatgga ctggatatta ccatcatcca ccatcctggc taccagatgg aaccttctct    360

tcttccttct cctcttccct ccagctcttg agcctaccct cctctcacat ctcctcctgc    420

ccaagatgta aggaagcatt gtaaggattt cttcccatcg tacccttccc cacacatacc    480

accttggctt cttctatatc ccaccccgat gctctcccag gtgggtgtga gagagacctc    540

attctctgca ggctccagcg tggccacagc taaggcccat ccatttccca aagtgaggaa    600

agtgtctggg cttcttctgg ggttccaccc tgacaagtag ggtcacagag gctggtgcac    660

agtttctgcc tcattcctct ccatgatgcc ccctgctctg ggcttctctc ctgttttccc    720

caataaatat gtgcctcatg taataaatgt gtctgcttcc tgggct                   766


<210>  326
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  326

Met Ser Ser Gln Gln Gln Gln Arg Gln Gln Gln Gln Cys Pro Pro Gln 
1               5                   10                  15      


Arg Ala Gln Gln Gln Gln Val Lys Gln Pro Cys Gln Pro Pro Pro Val 
            20                  25                  30          


Lys Cys Gln Glu Thr Cys Ala Pro Lys Thr Lys Asp Pro Cys Ala Pro 
        35                  40                  45              


Gln Val Lys Lys Gln Cys Pro Pro Lys Gly Thr Ile Ile Pro Ala Gln 
    50                  55                  60                  


Gln Lys Cys Pro Ser Ala Gln Gln Ala Ser Lys Ser Lys Gln Lys 
65                  70                  75                  


<210>  327
<211>  664
<212>  DNA
<213>  Homosapiens

<400>  327
accaaaccca agggaccaca cagcccattc tgctccgtat accagaaaaa aacacatttg     60

aagcatgaat tctcagcagc agaagcagcc ttgcacccca ccccctcagc ctcagcagca    120

gcaggtgaaa caaccttgcc agcctccacc ccaggaacca tgcatcccca aaaccaagga    180

gccctgccac cccaaggtgc ctgagccctg ccaccccaaa gtgcctgagc cctgccagcc    240

caaggttcca gagccctgcc agcccaaggt gcctgagccc tgcccttcaa cggtcactcc    300

agcaccagcc cagcagaaga ccaagcagaa gtaatgtggt ccacagccat gcccttgagg    360

agctggccac tggatactga acaccctact ccattctgct tatgaatccc atttgcctat    420

tgaccctgca gttagcatgc tgtcaccctg aatcataatc gctcctttgc acctctaaaa    480

agatgtccct taccctcatt ctggagggct cctgagcctc tgcgtaaggc tgaacgtctc    540

actgactgag ctagtcttct tgttgctcgg gtgcatttga ggatggattt ggggaaggat    600

caagtgaacc atccctagtc ttccttcaat aaataacttt taactccaaa aaaaaaaaaa    660

aaaa                                                                 664


<210>  328
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  328

Met Asn Ser Gln Gln Gln Lys Gln Pro Cys Thr Pro Pro Pro Gln Pro 
1               5                   10                  15      


Gln Gln Gln Gln Val Lys Gln Pro Cys Gln Pro Pro Pro Gln Glu Pro 
            20                  25                  30          


Cys Ile Pro Lys Thr Lys Glu Pro Cys His Pro Lys Val Pro Glu Pro 
        35                  40                  45              


Cys His Pro Lys Val Pro Glu Pro Cys Gln Pro Lys Val Pro Glu Pro 
    50                  55                  60                  


Cys Gln Pro Lys Val Pro Glu Pro Cys Pro Ser Thr Val Thr Pro Ala 
65                  70                  75                  80  


Pro Ala Gln Gln Lys Thr Lys Gln Lys 
                85                  


<210>  329
<211>  984
<212>  DNA
<213>  Homosapiens

<400>  329
accagatccc agaggctgaa cacctcgacc ttctctgcac agcagatgat ccctgagcag     60

ctgaagacca gaaaagccac taagactttc tgcttaattc aggagcttag aggattcttc    120

aaagagtgtg tccacgatcc tttgaagcat gagttcttac cagcagaagc agacctttac    180

cccaccacct cagcttcaac agcagcaggt gaaacaaccc agccagcctc cacctcagga    240

aatatttgtt cccacaacca aggagccatg ccactcaaag gttccacaac ctggaaacac    300

aaagattcca gagccaggct gtaccaaggt ccctgagcca ggctgtacca aggtccctga    360

gccaggctgt accaaggtcc ctgagccagg ttgtaccaag gtccctgagc caggctgtac    420

caaggtccct gagccaggtt gtaccaaggt ccctgagcca ggctacacca aggtccctga    480

accaggcagc atcaaggtcc ctgaccaagg cttcatcaag tttcctgagc caggtgccat    540

caaagttcct gagcaaggat acaccaaagt tcctgtgcca ggctacacaa agctaccaga    600

gccatgtcct tcaacggtca ctccaggccc agctcagcag aagaccaagc agaagtaatt    660

tggtgcacag acaagccctt gagaagccaa ccaccagatg ctggacaccc tcttcccatc    720

tgtttctgtg tcttaattgt ctgtagacct tgtaatcagc acattgtcac cccaagccat    780

agtctctctc ttatttgtat cctaaaaata cgtactataa agcttttgtt cacacacact    840

ctgaagaatc ctgtaagccc ctgaattaag cagaaagtct tcatggcttt tctggtcttc    900

ggctgctcag ggttcatctg aagattcgaa tgaaaagaaa tgcatgtttc ctgctcttcc    960

ctcattaaat tgcttttaat tcca                                           984


<210>  330
<211>  169
<212>  PRT
<213>  Homosapiens

<400>  330

Met Ser Ser Tyr Gln Gln Lys Gln Thr Phe Thr Pro Pro Pro Gln Leu 
1               5                   10                  15      


Gln Gln Gln Gln Val Lys Gln Pro Ser Gln Pro Pro Pro Gln Glu Ile 
            20                  25                  30          


Phe Val Pro Thr Thr Lys Glu Pro Cys His Ser Lys Val Pro Gln Pro 
        35                  40                  45              


Gly Asn Thr Lys Ile Pro Glu Pro Gly Cys Thr Lys Val Pro Glu Pro 
    50                  55                  60                  


Gly Cys Thr Lys Val Pro Glu Pro Gly Cys Thr Lys Val Pro Glu Pro 
65                  70                  75                  80  


Gly Cys Thr Lys Val Pro Glu Pro Gly Cys Thr Lys Val Pro Glu Pro 
                85                  90                  95      


Gly Cys Thr Lys Val Pro Glu Pro Gly Tyr Thr Lys Val Pro Glu Pro 
            100                 105                 110         


Gly Ser Ile Lys Val Pro Asp Gln Gly Phe Ile Lys Phe Pro Glu Pro 
        115                 120                 125             


Gly Ala Ile Lys Val Pro Glu Gln Gly Tyr Thr Lys Val Pro Val Pro 
    130                 135                 140                 


Gly Tyr Thr Lys Leu Pro Glu Pro Cys Pro Ser Thr Val Thr Pro Gly 
145                 150                 155                 160 


Pro Ala Gln Gln Lys Thr Lys Gln Lys 
                165                 


<210>  331
<211>  641
<212>  DNA
<213>  Homosapiens

<400>  331
accagttcta agggaccata cagagtattc ctctcttcac accaggacca gtcactgttg     60

cagcatgagt tcccagcagc agaagcagcc ttgcacccca ccccctcagc ttcagcagca    120

gcaggtgaaa cagccttgcc agcctccacc tcaggaacca tgcatcccca aaaccaagga    180

gccctgccac cccaaggtgc ctgagccctg ccaccccaaa gtgcccgagc cctgccagcc    240

caaggttcca gagccatgcc accccaaggt gcctgagccc tgcccttcaa tagtcactcc    300

agcaccagcc cagcagaaga ccaagcagaa gtaatgtggt ccacagccat gcccttgagg    360

agccggccac cagatgctga atcccctatc ccattctgcg tatgagtccc atttgccttg    420

caattagcat tctgtctccc ccaaaaaaga atgtgctatg aagctttctt tcctacacac    480

tctgagtctc tgaatgaagc tgaaggtctt agtaccagag ctagttttca gctgctcaga    540

attcatctga agagagactt aagatgaaag caaatgattc agctccctta tacccccatt    600

aaattcactt tcaattccaa aaaaaaaaaa aaaaaaaaaa a                        641


<210>  332
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  332

Met Ser Ser Gln Gln Gln Lys Gln Pro Cys Thr Pro Pro Pro Gln Leu 
1               5                   10                  15      


Gln Gln Gln Gln Val Lys Gln Pro Cys Gln Pro Pro Pro Gln Glu Pro 
            20                  25                  30          


Cys Ile Pro Lys Thr Lys Glu Pro Cys His Pro Lys Val Pro Glu Pro 
        35                  40                  45              


Cys His Pro Lys Val Pro Glu Pro Cys Gln Pro Lys Val Pro Glu Pro 
    50                  55                  60                  


Cys His Pro Lys Val Pro Glu Pro Cys Pro Ser Ile Val Thr Pro Ala 
65                  70                  75                  80  


Pro Ala Gln Gln Lys Thr Lys Gln Lys 
                85                  


<210>  333
<211>  662
<212>  DNA
<213>  Homosapiens

<400>  333
actcctggta ctctagcacc gatctgcttt ggagaaactg gttaattctg agactccagc     60

aggatgtctt atcaacagca gcagtgcaag cagccctgcc agccacctcc tgtgtgcccc    120

acgccaaagt gcccagagcc atgtccaccc ccgaagtgcc ctgagccctg cccaccacca    180

aagtgtccac agccctgccc acctcagcag tgccagcaga aatatcctcc tgtgacacct    240

tccccaccct gccagccaaa gtatccaccg aagagcaagt aacagcttca ggattcatca    300

ggagcatgag aggataagga taattggctc acctcgttcc acagctccac cttcatcttc    360

tcatcaaagc ttatcatgga ttcataggga gcttctttcc ccttagcctg tgatctgccc    420

atgatgttcc ctgatagcaa aaggtttcct ttctaaggct gccatactgc cactgtccag    480

gtggagactg agcaaaggaa ccttggcttt gtcagttccc agagcttcag cagaaagagc    540

tgcagctgtg tgcctgggaa ccatcagaga attctgttga tgtgttctgt gtctgtcttt    600

cacctgggca tgagcttcta ccacctgtgc aattgtcact tttctttcac tccctgaata    660

aa                                                                   662


<210>  334
<211>  72
<212>  PRT
<213>  Homosapiens

<400>  334

Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Pro Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Tyr Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Tyr Pro Pro Lys Ser Lys 
65                  70          


<210>  335
<211>  692
<212>  DNA
<213>  Homosapiens

<400>  335
aaacccctgg tacctgagca ctgatctgcc ttggagaacc tgatcctgag actccagcag     60

gatgtcttat caacagcagc agtgcaagca gccctgccag ccacctcctg tgtgccccac    120

gccaaagtgc ccagagccat gtccaccccc gaagtgccct gagccctgcc caccaccaaa    180

gtgtccacag ccctgcccac ctcagcagtg ccagcagaaa tatcctcctg tgacaccttc    240

cccaccctgc cagtcaaagt atccaccgaa gagcaagtaa cagcttcaga attcatcagg    300

accaagaaag gataaggata tttggctcac ctcgttccac agctccacct tcatcttctc    360

atcaaagcct accatggata cacagggagc ttctttctcc ttagccagta atctgcccat    420

gatgatccct gacagcaaaa agtttctttt ctgaggctgc catactgcca ctgtccaggt    480

ggagactgag caaaggaagt cctgggctgt gccagctccc agagcttcgg aagaaagagc    540

agcagctctc tccctgggaa ccatcagaga attctgttga tgtgttctgt gtctgtctgt    600

cacctggtca cgagcttcta ccacctttgc aattgtcact tatctttcac tccctgaata    660

aagtatctat gcatataaaa aaaaaaaaaa aa                                  692


<210>  336
<211>  72
<212>  PRT
<213>  Homosapiens

<400>  336

Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Pro Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Tyr Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Ser Lys Tyr Pro Pro Lys Ser Lys 
65                  70          


<210>  337
<211>  645
<212>  DNA
<213>  Homosapiens

<400>  337
atgctgttgg cttgtatctc tgatcaggta ccaccactgg aaggtacaca gagctatcag     60

caaggtttgt tcagtgttca tgctgttacc cgctgtactc cttgtgaggt gaagaagccc    120

ctgaagaact tcaagctttg cctgaaaacc ttcacagact tcacctgccc ttatagcctc    180

ttctacagca ctcggtccca ggacaatgag ctgcttctcc ttgtcaacaa aatgggaatg    240

tatctgctgc acattggaaa tgctgcagtc actttcaatg gccccacccc ctgccctcga    300

tctccttatg cttcgaccca tgtcaatgtg agctgggagt ctgcctctgg aattgctaca    360

ctctgggcaa atgggaagct ggtggggagg aagggtgtgt ggaaggggta ctctgtggga    420

gaagaggcta agatcatcct gggacaagag caggattcct ttgggggaca ttttgatgaa    480

aatcaatcct ttgttggggt gatatgggat gtgtttttgt gggatcatgt gctccctcca    540

aaggagatgt gtgactcctg ttacagcggc agcctcctga atcggcatac cctgacttat    600

gaagataatg gctatgtggt aactaagccc aaggtgtggg cttaa                    645


<210>  338
<211>  214
<212>  PRT
<213>  Homosapiens

<400>  338

Met Leu Leu Ala Cys Ile Ser Asp Gln Val Pro Pro Leu Glu Gly Thr 
1               5                   10                  15      


Gln Ser Tyr Gln Gln Gly Leu Phe Ser Val His Ala Val Thr Arg Cys 
            20                  25                  30          


Thr Pro Cys Glu Val Lys Lys Pro Leu Lys Asn Phe Lys Leu Cys Leu 
        35                  40                  45              


Lys Thr Phe Thr Asp Phe Thr Cys Pro Tyr Ser Leu Phe Tyr Ser Thr 
    50                  55                  60                  


Arg Ser Gln Asp Asn Glu Leu Leu Leu Leu Val Asn Lys Met Gly Met 
65                  70                  75                  80  


Tyr Leu Leu His Ile Gly Asn Ala Ala Val Thr Phe Asn Gly Pro Thr 
                85                  90                  95      


Pro Cys Pro Arg Ser Pro Tyr Ala Ser Thr His Val Asn Val Ser Trp 
            100                 105                 110         


Glu Ser Ala Ser Gly Ile Ala Thr Leu Trp Ala Asn Gly Lys Leu Val 
        115                 120                 125             


Gly Arg Lys Gly Val Trp Lys Gly Tyr Ser Val Gly Glu Glu Ala Lys 
    130                 135                 140                 


Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly His Phe Asp Glu 
145                 150                 155                 160 


Asn Gln Ser Phe Val Gly Val Ile Trp Asp Val Phe Leu Trp Asp His 
                165                 170                 175     


Val Leu Pro Pro Lys Glu Met Cys Asp Ser Cys Tyr Ser Gly Ser Leu 
            180                 185                 190         


Leu Asn Arg His Thr Leu Thr Tyr Glu Asp Asn Gly Tyr Val Val Thr 
        195                 200                 205             


Lys Pro Lys Val Trp Ala 
    210                 


<210>  339
<211>  1191
<212>  DNA
<213>  Homosapiens

<400>  339
agtctccagc atcctccacc tgtctaccac cgagcatggg cctatatttg aagccttaga     60

tctctccagc acagtaagca ccaggagtcc atgaagaaga tggctcctgc catggaatcc    120

cctactctac tgtgtgtagc cttactgttc ttcgctccag atggcgtgtt agcagtccct    180

cagaaaccta aggtctcctt gaaccctcca tggaatagaa tatttaaagg agagaatgtg    240

actcttacat gtaatgggaa caatttcttt gaagtcagtt ccaccaaatg gttccacaat    300

ggcagccttt cagaagagac aaattcaagt ttgaatattg tgaatgccaa atttgaagac    360

agtggagaat acaaatgtca gcaccaacaa gttaatgaga gtgaacctgt gtacctggaa    420

gtcttcagtg actggctgct ccttcaggcc tctgctgagg tggtgatgga gggccagccc    480

ctcttcctca ggtgccatgg ttggaggaac tgggatgtgt acaaggtgat ctattataag    540

gatggtgaag ctctcaagta ctggtatgag aaccacaaca tctccattac aaatgccaca    600

gttgaagaca gtggaaccta ctactgtacg ggcaaagtgt ggcagctgga ctatgagtct    660

gagcccctca acattactgt aataaaagct ccgcgtgaga agtactggct acaatttttt    720

atcccattgt tggtggtgat tctgtttgct gtggacacag gattatttat ctcaactcag    780

cagcaggtca catttctctt gaagattaag agaaccagga aaggcttcag acttctgaac    840

ccacatccta agccaaaccc caaaaacaac tgatataatt actcaagaaa tatttgcaac    900

attagttttt ttccagcatc agcaattgct actcaattgt caaacacagc ttgcaatata    960

catagaaacg tctgtgctca aggatttata gaaatgcttc attaaactga gtgaaactgg   1020

ttaagtggca tgtaatagta agtgctcaat taacattggt tgaataaatg agagaatgaa   1080

tagattcatt tattagcatt tgtaaaagag atgttcaatt tcaataaaat aaatataaaa   1140

ccatgtaaca gaatgcttct gagtaaaaaa aaaaaaaaaa aaaaaaaaaa a            1191


<210>  340
<211>  257
<212>  PRT
<213>  Homosapiens

<400>  340

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Lys Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp 
    50                  55                  60                  


Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile 
65                  70                  75                  80  


Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln 
                85                  90                  95      


Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp 
            100                 105                 110         


Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu 
        115                 120                 125             


Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile 
    130                 135                 140                 


Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn 
145                 150                 155                 160 


Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys 
                165                 170                 175     


Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile 
            180                 185                 190         


Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln Phe Phe Ile 
        195                 200                 205             


Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 
    210                 215                 220                 


Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 
225                 230                 235                 240 


Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 
                245                 250                 255     


Asn 
    


<210>  341
<211>  990
<212>  DNA
<213>  Homosapiens

<400>  341
atgccaaagc taaattccac ttttgtgact gagttcctct ttgaaggttt ctccagcttc     60

aggcggcagc acaaacttgt cttctttgtt gtcttcctaa ctttgtacct gctgactctc    120

tctggcaatg tgattatcat gaccattatt cgcctggacc atcatcttca cacccccatg    180

tacttcttcc tgtgcatgct atccatctct gagacctgct acactgtggc catcattccc    240

catatgcttt ctggtctctt gaatcctcat cagcccattg ccacccaaag ctgtgccact    300

cagctcttct tctatctcac ctttggcatc aacaactgct tcctgctcac agtcatggga    360

tatgaccgct atgtggccat ctgcaacccc ctaaggtatt cagtcatcat gggtaagagg    420

gcctgtatcc aactggcctc tggatcactg gggattggcc ttggcatggc cattgtccaa    480

gtaacatctg tgtttggcct gccattctgt gatgcctttg tcatctccca cttcttctgt    540

gatgtgagac acctgctgaa gctggcctgc acagacacca ctgtcaatga gataatcaac    600

tttgttgtca gcgtctgtgt ccttgttcta cctatgggcc tggtctttat ctcctatgtc    660

ctcatcatct ccaccattct taagattgcc tcagctgaag gtcagaagaa ggcctttgcc    720

acctgcgcct cccacctcac agtggtcatc atccactatg gctgtgcctc catcatctac    780

ctgaagccta agtcccagag ttccctggga caggacagac tcatctcagt gacctacact    840

catcactccc ctactgaacc ctgttgtgta cagcctgaag aacaaggagg tcaaagatgc    900

tctgcacaga gccgtggggc aaaaaactct gtctccttaa tgaagagagg ttgtgaaggc    960

ttttcctttg cgtttataaa tatgtactaa                                     990


<210>  342
<211>  329
<212>  PRT
<213>  Homosapiens

<400>  342

Met Pro Lys Leu Asn Ser Thr Phe Val Thr Glu Phe Leu Phe Glu Gly 
1               5                   10                  15      


Phe Ser Ser Phe Arg Arg Gln His Lys Leu Val Phe Phe Val Val Phe 
            20                  25                  30          


Leu Thr Leu Tyr Leu Leu Thr Leu Ser Gly Asn Val Ile Ile Met Thr 
        35                  40                  45              


Ile Ile Arg Leu Asp His His Leu His Thr Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Cys Met Leu Ser Ile Ser Glu Thr Cys Tyr Thr Val Ala Ile Ile Pro 
65                  70                  75                  80  


His Met Leu Ser Gly Leu Leu Asn Pro His Gln Pro Ile Ala Thr Gln 
                85                  90                  95      


Ser Cys Ala Thr Gln Leu Phe Phe Tyr Leu Thr Phe Gly Ile Asn Asn 
            100                 105                 110         


Cys Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys 
        115                 120                 125             


Asn Pro Leu Arg Tyr Ser Val Ile Met Gly Lys Arg Ala Cys Ile Gln 
    130                 135                 140                 


Leu Ala Ser Gly Ser Leu Gly Ile Gly Leu Gly Met Ala Ile Val Gln 
145                 150                 155                 160 


Val Thr Ser Val Phe Gly Leu Pro Phe Cys Asp Ala Phe Val Ile Ser 
                165                 170                 175     


His Phe Phe Cys Asp Val Arg His Leu Leu Lys Leu Ala Cys Thr Asp 
            180                 185                 190         


Thr Thr Val Asn Glu Ile Ile Asn Phe Val Val Ser Val Cys Val Leu 
        195                 200                 205             


Val Leu Pro Met Gly Leu Val Phe Ile Ser Tyr Val Leu Ile Ile Ser 
    210                 215                 220                 


Thr Ile Leu Lys Ile Ala Ser Ala Glu Gly Gln Lys Lys Ala Phe Ala 
225                 230                 235                 240 


Thr Cys Ala Ser His Leu Thr Val Val Ile Ile His Tyr Gly Cys Ala 
                245                 250                 255     


Ser Ile Ile Tyr Leu Lys Pro Lys Ser Gln Ser Ser Leu Gly Gln Asp 
            260                 265                 270         


Arg Leu Ile Ser Val Thr Tyr Thr His His Ser Pro Thr Glu Pro Cys 
        275                 280                 285             


Cys Val Gln Pro Glu Glu Gln Gly Gly Gln Arg Cys Ser Ala Gln Ser 
    290                 295                 300                 


Arg Gly Ala Lys Asn Ser Val Ser Leu Met Lys Arg Gly Cys Glu Gly 
305                 310                 315                 320 


Phe Ser Phe Ala Phe Ile Asn Met Tyr 
                325                 


<210>  343
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  343
atgcttttat gtttcagatt tgggaaccaa tccatgaaaa gagagaactt tactctcatc     60

actgactttg ttttccaagg tttctctagc ttccatgagc agcagatcac cctttttggc    120

gtgttccttg cactatacat cttaacctta gcaggcaata tcatcattgt gaccatcatc    180

cgaattgatc ttcatcttca cacacccatg tacttcttcc tgagcatgct gtccacttca    240

gagactgtat atacattggt cattctccca agaatgctct ccagcctcgt aggtatgagc    300

cagcccatgt cattggcagg gtgtgccaca cagatgttct tttttgtaac ctttggcatc    360

actaactgct tcctgctcac agcaatggga tatgaccgct atgtggccat ctgcaacccc    420

ctgagataca tggttattat gaacaagagg ctgcgtatcc aacttgtcct gggggcctgc    480

agcattgggc tgattgtagc aataacgcaa gtgacatctg tattcaggtt acccttctgt    540

gctagaaagg tgccccactt cttctgtgac atccgccctg tgatgaagct ctcctgcatt    600

gacaccactg tcaatgaaat cctgactttg attatcagtg tgctggtgct tgttgtacct    660

atgggtctgg ttttcatttc ttatgttctc attatctcta caatcctcaa gattgcttca    720

gttgagggcc ggaagaaggc ttttgccacc tgtgcatccc acctcactgt ggtcattgtc    780

cactacagct gtgcctccat tgcctacctc aagcccaagt cagagaacac cagagaacat    840

gaccagctga tctcggtgac ctacactgtc atcactcccc tactgaaccc tgtggtatac    900

accctgagaa ataaagaggt caaagatgct ctgtgcaggg ctgttggtgg gaagttttcc    960

tga                                                                  963


<210>  344
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  344

Met Leu Leu Cys Phe Arg Phe Gly Asn Gln Ser Met Lys Arg Glu Asn 
1               5                   10                  15      


Phe Thr Leu Ile Thr Asp Phe Val Phe Gln Gly Phe Ser Ser Phe His 
            20                  25                  30          


Glu Gln Gln Ile Thr Leu Phe Gly Val Phe Leu Ala Leu Tyr Ile Leu 
        35                  40                  45              


Thr Leu Ala Gly Asn Ile Ile Ile Val Thr Ile Ile Arg Ile Asp Leu 
    50                  55                  60                  


His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Met Leu Ser Thr Ser 
65                  70                  75                  80  


Glu Thr Val Tyr Thr Leu Val Ile Leu Pro Arg Met Leu Ser Ser Leu 
                85                  90                  95      


Val Gly Met Ser Gln Pro Met Ser Leu Ala Gly Cys Ala Thr Gln Met 
            100                 105                 110         


Phe Phe Phe Val Thr Phe Gly Ile Thr Asn Cys Phe Leu Leu Thr Ala 
        115                 120                 125             


Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Met 
    130                 135                 140                 


Val Ile Met Asn Lys Arg Leu Arg Ile Gln Leu Val Leu Gly Ala Cys 
145                 150                 155                 160 


Ser Ile Gly Leu Ile Val Ala Ile Thr Gln Val Thr Ser Val Phe Arg 
                165                 170                 175     


Leu Pro Phe Cys Ala Arg Lys Val Pro His Phe Phe Cys Asp Ile Arg 
            180                 185                 190         


Pro Val Met Lys Leu Ser Cys Ile Asp Thr Thr Val Asn Glu Ile Leu 
        195                 200                 205             


Thr Leu Ile Ile Ser Val Leu Val Leu Val Val Pro Met Gly Leu Val 
    210                 215                 220                 


Phe Ile Ser Tyr Val Leu Ile Ile Ser Thr Ile Leu Lys Ile Ala Ser 
225                 230                 235                 240 


Val Glu Gly Arg Lys Lys Ala Phe Ala Thr Cys Ala Ser His Leu Thr 
                245                 250                 255     


Val Val Ile Val His Tyr Ser Cys Ala Ser Ile Ala Tyr Leu Lys Pro 
            260                 265                 270         


Lys Ser Glu Asn Thr Arg Glu His Asp Gln Leu Ile Ser Val Thr Tyr 
        275                 280                 285             


Thr Val Ile Thr Pro Leu Leu Asn Pro Val Val Tyr Thr Leu Arg Asn 
    290                 295                 300                 


Lys Glu Val Lys Asp Ala Leu Cys Arg Ala Val Gly Gly Lys Phe Ser 
305                 310                 315                 320 


<210>  345
<211>  6940
<212>  DNA
<213>  Homosapiens

<400>  345
ggggatgact ctctctcttg agtaggcaca cactcccttt tctcgggtgt gtactttttg     60

ctttgtgata catctctgca ctttcagtat tttccaactc atccttaaat tccttctcac    120

aacagtgtca agagcctgga cgccagccag aattgaggtc ctacgggtgt ttggggacct    180

ccccaagccc acgagtatca atggcagtat caattgtctg tgacagtgat taaggagcaa    240

aacacttgga acccacaaga ctcccagaag gtgaagttaa gagctcccag actcataagg    300

ttattagaac agcaaactgg caccccaaag aactttacgg agacttgcaa cctatcaaca    360

agttggatga gggattaaaa gccttcaaca accaacaacc ccaagcatca aactgaagga    420

aacattctaa ccttcacaga cagactggag gctggatggg gacctggctg aagacatctg    480

gagaatgaaa gttaagtacc agcttgcatt tttgtgcccc tagattattt ttgcatttta    540

aaataagaag catcaaattg cgtgtctctg tgtaaaagtt ctagcaattt gttttaaggt    600

gaacttattt tggcttaggg actacaaaaa gagaaggtaa ttcctaggga aggaagaaga    660

gaaagaaatg aaaattagag aataagatta ttttgaatga cttcaggtag cgaggagtgt    720

gtgtttgtga gtgtgtattt gagagacttg gctcatgcct gtgggtcttc tcttctagta    780

tcagtgaggg gagggattac tgaagaagaa ggggggaaaa aaaaagaaag aaatctgagc    840

tttctgggag gaaattcaaa ggaaccaaga gaaattaact tcgttctgca aggactaaag    900

tacagcaaga ggagagaggt caagcgagaa gcgtgcggga agcacatgcc ctggggaggc    960

atagaagcca cactggcaga gcggccagca caggtagcca gcagaggcat tcttggggct   1020

atttgaaaaa gtttggtctg tgaacaaaac agtttccctg gtgactgcaa atccattgct   1080

agctgcctct ttctcgtctg cccatcactc tggtgtggta cccagaagtt gacttctggt   1140

tctgtagaaa gagctagggg aggtatgatg tgcttaaaga tcctaagaat aagcctggcg   1200

attttggctg ggtgggcact ctgttctgcc aactctgagc tgggctggac acgcaagaaa   1260

tccttggttg agagggaaca cctgaatcag gtgctgttgg aaggagaacg ttgttggctg   1320

ggggccaagg ttcgaagacc cagagcttct ccacagcatc acctctttgg agtctacccc   1380

agcagggctg ggaactacct aaggccctac cccgtggggg agcaagaaat ccatcataca   1440

ggacgcagca aaccagacac tgaaggaaat gctgtgagcc ttgttccccc agacctgact   1500

gaaaatccag caggactgag gggtgcagtt gaagagccgg ctgccccatg ggtaggggat   1560

agtcctattg ggcaatctga gctgctggga gatgatgacg cttatctcgg caatcaaaga   1620

tccaaggagt ctctaggtga ggccgggatt cagaaaggct cagccatggc tgccactact   1680

accaccgcca ttttcacaac cctgaacgaa cccaaaccag agacccaaag gaggggctgg   1740

gccaagtcca ggcagcgtcg ccaagtgtgg aagaggcggg cggaagatgg gcagggagac   1800

tccggtatct cttcacattt ccaaccttgg cccaagcatt cccttaaaca cagggtcaaa   1860

aagagtccac cggaggaaag caaccaaaat ggtggagagg gctcctaccg agaagcagag   1920

acctttaact cccaagtagg actgcccatc ttatacttct ctgggaggcg ggagcggctg   1980

ctgctgcgtc cagaagtgct ggctgagatt ccccgggagg cgttcacagt ggaagcctgg   2040

gttaaaccgg agggaggaca gaacaaccca gccatcatcg caggtgtgtt tgataactgc   2100

tcccacactg tcagtgacaa aggctgggcc ctggggatcc gctcagggaa ggacaaggga   2160

aagcgggatg ctcgcttctt cttctccctc tgcaccgacc gcgtgaagaa agccaccatc   2220

ttgattagcc acagtcgcta ccaaccaggc acatggaccc atgtggcagc cacttacgat   2280

ggacggcaca tggccctgta tgtggatggc actcaggtgg ctagcagtct agaccagtct   2340

ggtcccctga acagcccctt catggcatct tgccgctctt tgctcctggg gggagacagc   2400

tctgaggatg ggcactattt ccgtggacac ctgggcacac tggttttctg gtcgaccgcc   2460

ctgccacaaa gccattttca gcacagttct cagcattcaa gtgaggagga ggaagcgact   2520

gacttggtcc tgacagcgag ctttgagcct gtgaacacag agtgggttcc ctttagagat   2580

gagaagtacc cacgacttga ggttctccag ggctttgagc cagagcctga gattctgtcg   2640

cctttgcagc ccccactctg tgggcaaaca gtctgtgaca atgtggaatt gatctcccag   2700

tacaatggat actggcccct tcggggagag aaggtgatac gctaccaggt ggtgaacatc   2760

tgtgatgatg agggcctaaa ccccattgtg agtgaggagc agattcgtct gcagcacgag   2820

gcactgaatg aggccttcag ccgctacaac atcagctggc agctgagcgt ccaccaggtc   2880

cacaattcca ccctgcgaca ccgggttgtg cttgtgaact gtgagcccag caagattggc   2940

aatgaccatt gtgaccccga gtgtgagcac ccactcacag gctatgatgg gggtgactgc   3000

cgcctgcagg gccgctgcta ctcctggaac cgcagggatg ggctctgtca cgtggagtgt   3060

aacaacatgc tgaacgactt tgacgacgga gactgctgcg acccccaggt ggctgatgtg   3120

cgcaagacct gctttgaccc tgactcaccc aagagggcat acatgagtgt gaaggagctg   3180

aaggaggccc tgcagctgaa cagtactcac ttcctcaaca tctactttgc cagctcagtg   3240

cgggaagacc ttgcaggtgc tgccacctgg ccttgggaca aggacgctgt cactcacctg   3300

ggtggcattg tcctcagccc agcatattat gggatgcctg gccacaccga caccatgatc   3360

catgaagtgg gacatgttct gggactctac catgtcttta aaggagtcag tgaaagagaa   3420

tcctgcaatg acccctgcaa ggagacagtg ccatccatgg aaacgggaga cctctgtgcc   3480

gacaccgccc ccactcccaa gagtgagctg tgccgggaac cagagcccac tagtgacacc   3540

tgtggcttca ctcgcttccc aggggctccg ttcaccaact acatgagcta cacggatgat   3600

aactgcactg acaacttcac tcctaaccaa gtggcccgaa tgcattgcta tttggaccta   3660

gtctatcagc agtggactga aagcagaaag cccaccccca cccccattcc acctatggtc   3720

atcggacaga ccaacaagtc cctcactatc cactggctgc ctcctattag tggagttgta   3780

tatgacaggg cctcaggcag cttgtgtggc gcttgcactg aagatgggac ctttcgtcag   3840

tatgtgcaca cagcttcctc ccggcgggtg tgtgactcct caggttattg gaccccagag   3900

gaggctgtgg ggcctcctga tgtggatcag ccctgcgagc caagcttaca ggcctggagc   3960

cctgaggtcc acctgtacca catgaacatg acggtcccct gccccacaga aggctgtagc   4020

ttggagctgc tcttccaaca cccggtccaa gccgacaccc tcaccctgtg ggtcacttcc   4080

ttcttcatgg agtcctcgca ggtcctcttt gacacagaga tcttgctgga aaacaaggag   4140

tcagtgcacc tgggcccctt agacactttc tgtgacatcc cactcaccat caaactgcac   4200

gtggatggga aggtgtcggg ggtgaaagtc tacacctttg atgagaggat agagattgat   4260

gcagcactcc tgacttctca gccccacagt cccttgtgct ctggctgcag gcctgtgagg   4320

taccaggttc tccgcgatcc cccatttgcc agtggtttgc ccgtggtggt gacacattct   4380

cacaggaagt tcacggacgt ggaggtcaca cctggacaga tgtatcagta ccaagttcta   4440

gctgaagctg gaggagaact gggagaagct tcgcctcctc tgaaccacat tcatggagct   4500

ccttattgtg gagatgggaa ggtgtcagag agactgggag aagagtgtga tgatggagac   4560

cttgtgagcg gagatggctg ctccaaggtg tgtgagctgg aggaaggttt caactgtgta   4620

ggagagccaa gcctttgcta catgtatgag ggagatggca tatgtgaacc ttttgagaga   4680

aaaaccagca ttgtagactg tggcatctac actcccaaag gatacttgga tcaatgggct   4740

acccgggctt actcctctca tgaagacaag aagaagtgtc ctgtttcctt ggtaactgga   4800

gaacctcatt ccctaatttg cacatcatac catccagatt tacccaacca ccgtccccta   4860

actggctggt ttccctgtgt tgccagtgaa aatgaaactc aggatgacag gagtgaacag   4920

ccagaaggta gcctgaagaa agaggatgag gtttggctca aagtgtgttt caatagacca   4980

ggagaggcca gagcaatttt tatttttttg acaactgatg gcctagttcc cggagagcat   5040

cagcagccga cagtgactct ctacctgacc gatgtccgtg gaagcaacca ctctcttgga   5100

acctatggac tgtcatgcca gcataatcca ctgattatca atgtgaccca tcaccagaat   5160

gtccttttcc accataccac ctcagtgctg ccgaatttct catccccacg ggtcggcatc   5220

tcagctgtgg ctctaaggac atcctcccgc attggtcttt cggctcccag taactgcatc   5280

tcagaggacg aggggcagaa tcatcaggga cagagctgta tccatcggcc ctgtgggaag   5340

caggacagct gtccgtcatt gctgcttgat catgctgatg tggtgaactg tacctctata   5400

ggcccaggtc tcatgaagtg tgctatcact tgtcaaaggg gatttgccct tcaggccagc   5460

agtgggcagt acatcaggcc catgcagaag gaaattctgc tcacatgttc ttctgggcac   5520

tgggaccaga atgtgagctg ccttcccgtg gactgcggtg ttcccgaccc gtctttggtg   5580

aactatgcaa acttctcctg ctcagaggga accaaatttc tgaaacgctg ctcaatctct   5640

tgtgtcccac cagccaagct gcaaggactg agcccatggc tgacatgtct tgaagatggt   5700

ctctggtctc tccctgaagt ctactgcaag ttggagtgtg atgctccccc tattattctg   5760

aatgccaact tgctcctgcc tcactgcctc caggacaacc acgacgtggg caccatctgc   5820

aaatatgaat gcaaaccagg gtactatgtg gcagaaagtg cagagggtaa agtcaggaac   5880

aagctcctga agatacaatg cctggaaggt ggaatctggg agcaaggcag ctgcattcct   5940

gtggtgtgtg agccaccccc tcctgtgttt gaaggcatgt atgaatgtac caatggcttc   6000

agcctggaca gccagtgtgt gctcaactgt aaccaggaac gtgaaaagct tcccatcctc   6060

tgcactaaag agggcctgtg gacccaggag tttaagttgt gtgagaatct gcaaggagaa   6120

tgcccaccac ccccctcaga gctgaattct gtggagtaca aatgtgaaca aggatatggg   6180

attggtgcag tgtgttcccc attgtgtgta atccccccca gtgaccccgt gatgctacct   6240

gagaatatca ctgctgacac tctggagcac tggatggaac ctgtcaaagt ccagagcatt   6300

gtgtgcactg gccggcgtca atggcaccca gaccccgtct tagtccactg catccagtca   6360

tgtgagccct tccaagcaga tggttggtgt gacactatca acaaccgagc ctactgccac   6420

tatgacgggg gagactgctg ctcttccaca ctctcctcca agaaggtcat tccatttgct   6480

gctgactgtg acctggatga gtgcacctgc cgggacccca aggcagaaga aaatcagtaa   6540

ctgtgggaac aagcccctcc ctccactgcc tcagaggcag taagaaagag aggccgaccc   6600

aggaggaaac aaagggtgaa tgaagaagaa caatcatgaa atggaagaag gaggaagagc   6660

atgaaggatc ttataagaaa tgcaagagga tattgatagg tgtgaactag ttcatcaagt   6720

agcccaagta ggagagaatc ataggcaaaa gtttctttaa agtggcagtt gattaacatg   6780

gaaggggaaa tatgatagat atataaggac cctcctccct cacttatatt ctattaaatc   6840

ctatcctcaa ctcttgccct gctctccgct ccaccccctg ccaactactc agtcccaccc   6900

aacttgtaaa ccaataccaa aaaaaaaaaa aaaaaaaaaa                         6940


<210>  346
<211>  1790
<212>  PRT
<213>  Homosapiens

<400>  346

Met Cys Leu Lys Ile Leu Arg Ile Ser Leu Ala Ile Leu Ala Gly Trp 
1               5                   10                  15      


Ala Leu Cys Ser Ala Asn Ser Glu Leu Gly Trp Thr Arg Lys Lys Ser 
            20                  25                  30          


Leu Val Glu Arg Glu His Leu Asn Gln Val Leu Leu Glu Gly Glu Arg 
        35                  40                  45              


Cys Trp Leu Gly Ala Lys Val Arg Arg Pro Arg Ala Ser Pro Gln His 
    50                  55                  60                  


His Leu Phe Gly Val Tyr Pro Ser Arg Ala Gly Asn Tyr Leu Arg Pro 
65                  70                  75                  80  


Tyr Pro Val Gly Glu Gln Glu Ile His His Thr Gly Arg Ser Lys Pro 
                85                  90                  95      


Asp Thr Glu Gly Asn Ala Val Ser Leu Val Pro Pro Asp Leu Thr Glu 
            100                 105                 110         


Asn Pro Ala Gly Leu Arg Gly Ala Val Glu Glu Pro Ala Ala Pro Trp 
        115                 120                 125             


Val Gly Asp Ser Pro Ile Gly Gln Ser Glu Leu Leu Gly Asp Asp Asp 
    130                 135                 140                 


Ala Tyr Leu Gly Asn Gln Arg Ser Lys Glu Ser Leu Gly Glu Ala Gly 
145                 150                 155                 160 


Ile Gln Lys Gly Ser Ala Met Ala Ala Thr Thr Thr Thr Ala Ile Phe 
                165                 170                 175     


Thr Thr Leu Asn Glu Pro Lys Pro Glu Thr Gln Arg Arg Gly Trp Ala 
            180                 185                 190         


Lys Ser Arg Gln Arg Arg Gln Val Trp Lys Arg Arg Ala Glu Asp Gly 
        195                 200                 205             


Gln Gly Asp Ser Gly Ile Ser Ser His Phe Gln Pro Trp Pro Lys His 
    210                 215                 220                 


Ser Leu Lys His Arg Val Lys Lys Ser Pro Pro Glu Glu Ser Asn Gln 
225                 230                 235                 240 


Asn Gly Gly Glu Gly Ser Tyr Arg Glu Ala Glu Thr Phe Asn Ser Gln 
                245                 250                 255     


Val Gly Leu Pro Ile Leu Tyr Phe Ser Gly Arg Arg Glu Arg Leu Leu 
            260                 265                 270         


Leu Arg Pro Glu Val Leu Ala Glu Ile Pro Arg Glu Ala Phe Thr Val 
        275                 280                 285             


Glu Ala Trp Val Lys Pro Glu Gly Gly Gln Asn Asn Pro Ala Ile Ile 
    290                 295                 300                 


Ala Gly Val Phe Asp Asn Cys Ser His Thr Val Ser Asp Lys Gly Trp 
305                 310                 315                 320 


Ala Leu Gly Ile Arg Ser Gly Lys Asp Lys Gly Lys Arg Asp Ala Arg 
                325                 330                 335     


Phe Phe Phe Ser Leu Cys Thr Asp Arg Val Lys Lys Ala Thr Ile Leu 
            340                 345                 350         


Ile Ser His Ser Arg Tyr Gln Pro Gly Thr Trp Thr His Val Ala Ala 
        355                 360                 365             


Thr Tyr Asp Gly Arg His Met Ala Leu Tyr Val Asp Gly Thr Gln Val 
    370                 375                 380                 


Ala Ser Ser Leu Asp Gln Ser Gly Pro Leu Asn Ser Pro Phe Met Ala 
385                 390                 395                 400 


Ser Cys Arg Ser Leu Leu Leu Gly Gly Asp Ser Ser Glu Asp Gly His 
                405                 410                 415     


Tyr Phe Arg Gly His Leu Gly Thr Leu Val Phe Trp Ser Thr Ala Leu 
            420                 425                 430         


Pro Gln Ser His Phe Gln His Ser Ser Gln His Ser Ser Glu Glu Glu 
        435                 440                 445             


Glu Ala Thr Asp Leu Val Leu Thr Ala Ser Phe Glu Pro Val Asn Thr 
    450                 455                 460                 


Glu Trp Val Pro Phe Arg Asp Glu Lys Tyr Pro Arg Leu Glu Val Leu 
465                 470                 475                 480 


Gln Gly Phe Glu Pro Glu Pro Glu Ile Leu Ser Pro Leu Gln Pro Pro 
                485                 490                 495     


Leu Cys Gly Gln Thr Val Cys Asp Asn Val Glu Leu Ile Ser Gln Tyr 
            500                 505                 510         


Asn Gly Tyr Trp Pro Leu Arg Gly Glu Lys Val Ile Arg Tyr Gln Val 
        515                 520                 525             


Val Asn Ile Cys Asp Asp Glu Gly Leu Asn Pro Ile Val Ser Glu Glu 
    530                 535                 540                 


Gln Ile Arg Leu Gln His Glu Ala Leu Asn Glu Ala Phe Ser Arg Tyr 
545                 550                 555                 560 


Asn Ile Ser Trp Gln Leu Ser Val His Gln Val His Asn Ser Thr Leu 
                565                 570                 575     


Arg His Arg Val Val Leu Val Asn Cys Glu Pro Ser Lys Ile Gly Asn 
            580                 585                 590         


Asp His Cys Asp Pro Glu Cys Glu His Pro Leu Thr Gly Tyr Asp Gly 
        595                 600                 605             


Gly Asp Cys Arg Leu Gln Gly Arg Cys Tyr Ser Trp Asn Arg Arg Asp 
    610                 615                 620                 


Gly Leu Cys His Val Glu Cys Asn Asn Met Leu Asn Asp Phe Asp Asp 
625                 630                 635                 640 


Gly Asp Cys Cys Asp Pro Gln Val Ala Asp Val Arg Lys Thr Cys Phe 
                645                 650                 655     


Asp Pro Asp Ser Pro Lys Arg Ala Tyr Met Ser Val Lys Glu Leu Lys 
            660                 665                 670         


Glu Ala Leu Gln Leu Asn Ser Thr His Phe Leu Asn Ile Tyr Phe Ala 
        675                 680                 685             


Ser Ser Val Arg Glu Asp Leu Ala Gly Ala Ala Thr Trp Pro Trp Asp 
    690                 695                 700                 


Lys Asp Ala Val Thr His Leu Gly Gly Ile Val Leu Ser Pro Ala Tyr 
705                 710                 715                 720 


Tyr Gly Met Pro Gly His Thr Asp Thr Met Ile His Glu Val Gly His 
                725                 730                 735     


Val Leu Gly Leu Tyr His Val Phe Lys Gly Val Ser Glu Arg Glu Ser 
            740                 745                 750         


Cys Asn Asp Pro Cys Lys Glu Thr Val Pro Ser Met Glu Thr Gly Asp 
        755                 760                 765             


Leu Cys Ala Asp Thr Ala Pro Thr Pro Lys Ser Glu Leu Cys Arg Glu 
    770                 775                 780                 


Pro Glu Pro Thr Ser Asp Thr Cys Gly Phe Thr Arg Phe Pro Gly Ala 
785                 790                 795                 800 


Pro Phe Thr Asn Tyr Met Ser Tyr Thr Asp Asp Asn Cys Thr Asp Asn 
                805                 810                 815     


Phe Thr Pro Asn Gln Val Ala Arg Met His Cys Tyr Leu Asp Leu Val 
            820                 825                 830         


Tyr Gln Gln Trp Thr Glu Ser Arg Lys Pro Thr Pro Thr Pro Ile Pro 
        835                 840                 845             


Pro Met Val Ile Gly Gln Thr Asn Lys Ser Leu Thr Ile His Trp Leu 
    850                 855                 860                 


Pro Pro Ile Ser Gly Val Val Tyr Asp Arg Ala Ser Gly Ser Leu Cys 
865                 870                 875                 880 


Gly Ala Cys Thr Glu Asp Gly Thr Phe Arg Gln Tyr Val His Thr Ala 
                885                 890                 895     


Ser Ser Arg Arg Val Cys Asp Ser Ser Gly Tyr Trp Thr Pro Glu Glu 
            900                 905                 910         


Ala Val Gly Pro Pro Asp Val Asp Gln Pro Cys Glu Pro Ser Leu Gln 
        915                 920                 925             


Ala Trp Ser Pro Glu Val His Leu Tyr His Met Asn Met Thr Val Pro 
    930                 935                 940                 


Cys Pro Thr Glu Gly Cys Ser Leu Glu Leu Leu Phe Gln His Pro Val 
945                 950                 955                 960 


Gln Ala Asp Thr Leu Thr Leu Trp Val Thr Ser Phe Phe Met Glu Ser 
                965                 970                 975     


Ser Gln Val Leu Phe Asp Thr Glu Ile Leu Leu Glu Asn Lys Glu Ser 
            980                 985                 990         


Val His Leu Gly Pro Leu Asp Thr  Phe Cys Asp Ile Pro  Leu Thr Ile 
        995                 1000                 1005             


Lys Leu  His Val Asp Gly Lys  Val Ser Gly Val Lys  Val Tyr Thr 
    1010                 1015                 1020             


Phe Asp  Glu Arg Ile Glu Ile  Asp Ala Ala Leu Leu  Thr Ser Gln 
    1025                 1030                 1035             


Pro His  Ser Pro Leu Cys Ser  Gly Cys Arg Pro Val  Arg Tyr Gln 
    1040                 1045                 1050             


Val Leu  Arg Asp Pro Pro Phe  Ala Ser Gly Leu Pro  Val Val Val 
    1055                 1060                 1065             


Thr His  Ser His Arg Lys Phe  Thr Asp Val Glu Val  Thr Pro Gly 
    1070                 1075                 1080             


Gln Met  Tyr Gln Tyr Gln Val  Leu Ala Glu Ala Gly  Gly Glu Leu 
    1085                 1090                 1095             


Gly Glu  Ala Ser Pro Pro Leu  Asn His Ile His Gly  Ala Pro Tyr 
    1100                 1105                 1110             


Cys Gly  Asp Gly Lys Val Ser  Glu Arg Leu Gly Glu  Glu Cys Asp 
    1115                 1120                 1125             


Asp Gly  Asp Leu Val Ser Gly  Asp Gly Cys Ser Lys  Val Cys Glu 
    1130                 1135                 1140             


Leu Glu  Glu Gly Phe Asn Cys  Val Gly Glu Pro Ser  Leu Cys Tyr 
    1145                 1150                 1155             


Met Tyr  Glu Gly Asp Gly Ile  Cys Glu Pro Phe Glu  Arg Lys Thr 
    1160                 1165                 1170             


Ser Ile  Val Asp Cys Gly Ile  Tyr Thr Pro Lys Gly  Tyr Leu Asp 
    1175                 1180                 1185             


Gln Trp  Ala Thr Arg Ala Tyr  Ser Ser His Glu Asp  Lys Lys Lys 
    1190                 1195                 1200             


Cys Pro  Val Ser Leu Val Thr  Gly Glu Pro His Ser  Leu Ile Cys 
    1205                 1210                 1215             


Thr Ser  Tyr His Pro Asp Leu  Pro Asn His Arg Pro  Leu Thr Gly 
    1220                 1225                 1230             


Trp Phe  Pro Cys Val Ala Ser  Glu Asn Glu Thr Gln  Asp Asp Arg 
    1235                 1240                 1245             


Ser Glu  Gln Pro Glu Gly Ser  Leu Lys Lys Glu Asp  Glu Val Trp 
    1250                 1255                 1260             


Leu Lys  Val Cys Phe Asn Arg  Pro Gly Glu Ala Arg  Ala Ile Phe 
    1265                 1270                 1275             


Ile Phe  Leu Thr Thr Asp Gly  Leu Val Pro Gly Glu  His Gln Gln 
    1280                 1285                 1290             


Pro Thr  Val Thr Leu Tyr Leu  Thr Asp Val Arg Gly  Ser Asn His 
    1295                 1300                 1305             


Ser Leu  Gly Thr Tyr Gly Leu  Ser Cys Gln His Asn  Pro Leu Ile 
    1310                 1315                 1320             


Ile Asn  Val Thr His His Gln  Asn Val Leu Phe His  His Thr Thr 
    1325                 1330                 1335             


Ser Val  Leu Pro Asn Phe Ser  Ser Pro Arg Val Gly  Ile Ser Ala 
    1340                 1345                 1350             


Val Ala  Leu Arg Thr Ser Ser  Arg Ile Gly Leu Ser  Ala Pro Ser 
    1355                 1360                 1365             


Asn Cys  Ile Ser Glu Asp Glu  Gly Gln Asn His Gln  Gly Gln Ser 
    1370                 1375                 1380             


Cys Ile  His Arg Pro Cys Gly  Lys Gln Asp Ser Cys  Pro Ser Leu 
    1385                 1390                 1395             


Leu Leu  Asp His Ala Asp Val  Val Asn Cys Thr Ser  Ile Gly Pro 
    1400                 1405                 1410             


Gly Leu  Met Lys Cys Ala Ile  Thr Cys Gln Arg Gly  Phe Ala Leu 
    1415                 1420                 1425             


Gln Ala  Ser Ser Gly Gln Tyr  Ile Arg Pro Met Gln  Lys Glu Ile 
    1430                 1435                 1440             


Leu Leu  Thr Cys Ser Ser Gly  His Trp Asp Gln Asn  Val Ser Cys 
    1445                 1450                 1455             


Leu Pro  Val Asp Cys Gly Val  Pro Asp Pro Ser Leu  Val Asn Tyr 
    1460                 1465                 1470             


Ala Asn  Phe Ser Cys Ser Glu  Gly Thr Lys Phe Leu  Lys Arg Cys 
    1475                 1480                 1485             


Ser Ile  Ser Cys Val Pro Pro  Ala Lys Leu Gln Gly  Leu Ser Pro 
    1490                 1495                 1500             


Trp Leu  Thr Cys Leu Glu Asp  Gly Leu Trp Ser Leu  Pro Glu Val 
    1505                 1510                 1515             


Tyr Cys  Lys Leu Glu Cys Asp  Ala Pro Pro Ile Ile  Leu Asn Ala 
    1520                 1525                 1530             


Asn Leu  Leu Leu Pro His Cys  Leu Gln Asp Asn His  Asp Val Gly 
    1535                 1540                 1545             


Thr Ile  Cys Lys Tyr Glu Cys  Lys Pro Gly Tyr Tyr  Val Ala Glu 
    1550                 1555                 1560             


Ser Ala  Glu Gly Lys Val Arg  Asn Lys Leu Leu Lys  Ile Gln Cys 
    1565                 1570                 1575             


Leu Glu  Gly Gly Ile Trp Glu  Gln Gly Ser Cys Ile  Pro Val Val 
    1580                 1585                 1590             


Cys Glu  Pro Pro Pro Pro Val  Phe Glu Gly Met Tyr  Glu Cys Thr 
    1595                 1600                 1605             


Asn Gly  Phe Ser Leu Asp Ser  Gln Cys Val Leu Asn  Cys Asn Gln 
    1610                 1615                 1620             


Glu Arg  Glu Lys Leu Pro Ile  Leu Cys Thr Lys Glu  Gly Leu Trp 
    1625                 1630                 1635             


Thr Gln  Glu Phe Lys Leu Cys  Glu Asn Leu Gln Gly  Glu Cys Pro 
    1640                 1645                 1650             


Pro Pro  Pro Ser Glu Leu Asn  Ser Val Glu Tyr Lys  Cys Glu Gln 
    1655                 1660                 1665             


Gly Tyr  Gly Ile Gly Ala Val  Cys Ser Pro Leu Cys  Val Ile Pro 
    1670                 1675                 1680             


Pro Ser  Asp Pro Val Met Leu  Pro Glu Asn Ile Thr  Ala Asp Thr 
    1685                 1690                 1695             


Leu Glu  His Trp Met Glu Pro  Val Lys Val Gln Ser  Ile Val Cys 
    1700                 1705                 1710             


Thr Gly  Arg Arg Gln Trp His  Pro Asp Pro Val Leu  Val His Cys 
    1715                 1720                 1725             


Ile Gln  Ser Cys Glu Pro Phe  Gln Ala Asp Gly Trp  Cys Asp Thr 
    1730                 1735                 1740             


Ile Asn  Asn Arg Ala Tyr Cys  His Tyr Asp Gly Gly  Asp Cys Cys 
    1745                 1750                 1755             


Ser Ser  Thr Leu Ser Ser Lys  Lys Val Ile Pro Phe  Ala Ala Asp 
    1760                 1765                 1770             


Cys Asp  Leu Asp Glu Cys Thr  Cys Arg Asp Pro Lys  Ala Glu Glu 
    1775                 1780                 1785             


Asn Gln  
    1790 


<210>  347
<211>  4076
<212>  DNA
<213>  Homosapiens

<400>  347
ggggatgact ctctctcttg agtaggcaca cactcccttt tctcgggtgt gtactttttg     60

ctttgtgata catctctgca ctttcagtat tttccaactc atccttaaat tccttctcac    120

aacagtgtca agagcctgga cgccagccag aattgaggtc ctacgggtgt ttggggacct    180

ccccaagccc acgagtatca atggcagtat caattgtctg tgacagtgat taaggagcaa    240

aacacttgga acccacaaga ctcccagaag gtgaagttaa gagctcccag actcataagg    300

ttattagaac agcaaactgg caccccaaag aactttacgg agacttgcaa cctatcaaca    360

agttggatga gggattaaaa gccttcaaca accaacaacc ccaagcatca aactgaagga    420

aacattctaa ccttcacaga cagactggag gctggatggg gacctggctg aagacatctg    480

gagaatgaaa gttaagtacc agcttgcatt tttgtgcccc tagattattt ttgcatttta    540

aaataagaag catcaaattg cgtgtctctg tgtaaaagtt ctagcaattt gttttaaggt    600

gaacttattt tggcttaggg actacaaaaa gagaaggtaa ttcctaggga aggaagaaga    660

gaaagaaatg aaaattagag aataagatta ttttgaatga cttcaggtag cgaggagtgt    720

gtgtttgtga gtgtgtattt gagagacttg gctcatgcct gtgggtcttc tcttctagta    780

tcagtgaggg gagggattac tgaagaagaa ggggggaaaa aaaaagaaag aaatctgagc    840

tttctgggag gaaattcaaa ggaaccaaga gaaattaact tcgttctgca aggactaaag    900

tacagcaaga ggagagaggt caagcgagaa gcgtgcggga agcacatgcc ctggggaggc    960

atagaagcca cactggcaga gcggccagca caggtagcca gcagaggcat tcttggggct   1020

atttgaaaaa gtttggtctg tgaacaaaac agtttccctg gtgactgcaa atccattgct   1080

agctgcctct ttctcgtctg cccatcactc tggtgtggta cccagaagtt gacttctggt   1140

tctgtagaaa gagctagggg aggtatgatg tgcttaaaga tcctaagaat aagcctggcg   1200

attttggctg ggtgggcact ctgttctgcc aactctgagc tgggctggac acgcaagaaa   1260

tccttggttg agagggaaca cctgaatcag gtgctgttgg aaggagaacg ttgttggctg   1320

ggggccaagg ttcgaagacc cagagcttct ccacagcatc acctctttgg agtctacccc   1380

agcagggctg ggaactacct aaggccctac cccgtggggg agcaagaaat ccatcataca   1440

ggacgcagca aaccagacac tgaaggaaat gctgtgagcc ttgttccccc agacctgact   1500

gaaaatccag caggactgag gggtgcagtt gaagagccgg ctgccccatg ggtaggggat   1560

agtcctattg ggcaatctga gctgctggga gatgatgacg cttatctcgg caatcaaaga   1620

tccaaggagt ctctaggtga ggccgggatt cagaaaggct cagccatggc tgccactact   1680

accaccgcca ttttcacaac cctgaacgaa cccaaaccag agacccaaag gaggggctgg   1740

gccaagtcca ggcagcgtcg ccaagtgtgg aagaggcggg cggaagatgg gcagggagac   1800

tccggtatct cttcacattt ccaaccttgg cccaagcatt cccttaaaca cagggtcaaa   1860

aagagtccac cggaggaaag caaccaaaat ggtggagagg gctcctaccg agaagcagag   1920

acctttaact cccaagtagg actgcccatc ttatacttct ctgggaggcg ggagcggctg   1980

ctgctgcgtc cagaagtgct ggctgagatt ccccgggagg cgttcacagt ggaagcctgg   2040

gttaaaccgg agggaggaca gaacaaccca gccatcatcg caggtgtgtt tgataactgc   2100

tcccacactg tcagtgacaa aggctgggcc ctggggatcc gctcagggaa ggacaaggga   2160

aagcgggatg ctcgcttctt cttctccctc tgcaccgacc gcgtgaagaa agccaccatc   2220

ttgattagcc acagtcgcta ccaaccaggc acatggaccc atgtggcagc cacttacgat   2280

ggacggcaca tggccctgta tgtggatggc actcaggtgg ctagcagtct agaccagtct   2340

ggtcccctga acagcccctt catggcatct tgccgctctt tgctcctggg gggagacagc   2400

tctgaggatg ggcactattt ccgtggacac ctgggcacac tggttttctg gtcgaccgcc   2460

ctgccacaaa gccattttca gcacagttct cagcattcaa gtggggagga ggaagcgact   2520

gacttggtcc tgacagcgag ctttgagcct gtgaacacag agtgggttcc ctttagagat   2580

gagaagtacc cacgacttga ggttctccag ggctttgagc cagagcctga gattctgtcg   2640

cctttgcagc ccccactctg tgggcaaaca gtctgtgaca atgtggaatt gatctcccag   2700

tacaatggat actggcccct tcggggagag aaggtgatac gctaccaggt ggtgaacatc   2760

tgtgatgatg agggcctaaa ccccattgtg agtgaggagc agattcgtct gcagcacgag   2820

gcactgaatg aggccttcag ccgctacaac atcagctggc agctgaacgt ccaccaggtc   2880

cacaattcca ccctgcgaca ccgggttgtg cttgtgaact gcgagcccag caagattggc   2940

aatgaccatt gtgaccccga gtgtgagcac ccactcacag gctatgatgg gggtgactgc   3000

cgcctgcagg gccgctgcta ctcctggaac cgcagggatg ggctctgtca cgtggagtgt   3060

aacaacatgc tgaacgactt tgacgacgga gactgctgcg acccccaggt ggctgatgtg   3120

cgcaagacct gctttgaccc tgactcaccc aagagggcat acatgagtgt gaaggagctg   3180

aaggaggccc tgcagctgaa cagtactcac ttcctcaaca tctactttgc cagctcagtg   3240

cgggaagacc ttgcaggtgc tgccacctgg ccttgggaca aggacgctgt cactcacctg   3300

ggtggcattg tcctcagccc agcatattat gggatgcctg gccacaccga caccatgatc   3360

catgaagtgg gacatgttct gggactctac catgtcttta aaggagtcag tgaaagagaa   3420

tcctgcaatg acccctgcaa ggagacagtg ccatccatgg aaacgggaga cctctgtgcc   3480

gacaccgccc ctactcccaa gagtgagctg tgccgggaac cagagcccac tagtgacacc   3540

tgtggcttca ctcgcttccc aggggctccg ttcaccaact acatgagcta cacgggtatc   3600

accactgtct tgttttgttt tctgttaaga atacatgggg gcctttgaga gctgggaggg   3660

tggaggtgtg ggagctgatg ggagaatgat taagtggtca tttgtgtcgg agagttgaag   3720

tgtatttatt ataaggtatt attatttttt catgtctttg aagaacttga agaaatactg   3780

acatattaag gtactttgtt cactgaattc tctcctacag atattttaaa atatacttct   3840

atcctcgata gtaaaaaagg cacagagcca aaagccctct tgtgatcccc ttgacttcta   3900

gaatgtggtt attcttattt ttggccgcat tcttagacat ttactctgag agagtccatg   3960

gaataaagga aagagttatg ggccaggggc catgtactgt tttgaagtgg caacaagggg   4020

ctggtaatta ggccacatgt ttactgatgt acgaaaaaaa aaaaaaaaaa aaaaaa       4076


<210>  348
<211>  826
<212>  PRT
<213>  Homosapiens

<400>  348

Met Cys Leu Lys Ile Leu Arg Ile Ser Leu Ala Ile Leu Ala Gly Trp 
1               5                   10                  15      


Ala Leu Cys Ser Ala Asn Ser Glu Leu Gly Trp Thr Arg Lys Lys Ser 
            20                  25                  30          


Leu Val Glu Arg Glu His Leu Asn Gln Val Leu Leu Glu Gly Glu Arg 
        35                  40                  45              


Cys Trp Leu Gly Ala Lys Val Arg Arg Pro Arg Ala Ser Pro Gln His 
    50                  55                  60                  


His Leu Phe Gly Val Tyr Pro Ser Arg Ala Gly Asn Tyr Leu Arg Pro 
65                  70                  75                  80  


Tyr Pro Val Gly Glu Gln Glu Ile His His Thr Gly Arg Ser Lys Pro 
                85                  90                  95      


Asp Thr Glu Gly Asn Ala Val Ser Leu Val Pro Pro Asp Leu Thr Glu 
            100                 105                 110         


Asn Pro Ala Gly Leu Arg Gly Ala Val Glu Glu Pro Ala Ala Pro Trp 
        115                 120                 125             


Val Gly Asp Ser Pro Ile Gly Gln Ser Glu Leu Leu Gly Asp Asp Asp 
    130                 135                 140                 


Ala Tyr Leu Gly Asn Gln Arg Ser Lys Glu Ser Leu Gly Glu Ala Gly 
145                 150                 155                 160 


Ile Gln Lys Gly Ser Ala Met Ala Ala Thr Thr Thr Thr Ala Ile Phe 
                165                 170                 175     


Thr Thr Leu Asn Glu Pro Lys Pro Glu Thr Gln Arg Arg Gly Trp Ala 
            180                 185                 190         


Lys Ser Arg Gln Arg Arg Gln Val Trp Lys Arg Arg Ala Glu Asp Gly 
        195                 200                 205             


Gln Gly Asp Ser Gly Ile Ser Ser His Phe Gln Pro Trp Pro Lys His 
    210                 215                 220                 


Ser Leu Lys His Arg Val Lys Lys Ser Pro Pro Glu Glu Ser Asn Gln 
225                 230                 235                 240 


Asn Gly Gly Glu Gly Ser Tyr Arg Glu Ala Glu Thr Phe Asn Ser Gln 
                245                 250                 255     


Val Gly Leu Pro Ile Leu Tyr Phe Ser Gly Arg Arg Glu Arg Leu Leu 
            260                 265                 270         


Leu Arg Pro Glu Val Leu Ala Glu Ile Pro Arg Glu Ala Phe Thr Val 
        275                 280                 285             


Glu Ala Trp Val Lys Pro Glu Gly Gly Gln Asn Asn Pro Ala Ile Ile 
    290                 295                 300                 


Ala Gly Val Phe Asp Asn Cys Ser His Thr Val Ser Asp Lys Gly Trp 
305                 310                 315                 320 


Ala Leu Gly Ile Arg Ser Gly Lys Asp Lys Gly Lys Arg Asp Ala Arg 
                325                 330                 335     


Phe Phe Phe Ser Leu Cys Thr Asp Arg Val Lys Lys Ala Thr Ile Leu 
            340                 345                 350         


Ile Ser His Ser Arg Tyr Gln Pro Gly Thr Trp Thr His Val Ala Ala 
        355                 360                 365             


Thr Tyr Asp Gly Arg His Met Ala Leu Tyr Val Asp Gly Thr Gln Val 
    370                 375                 380                 


Ala Ser Ser Leu Asp Gln Ser Gly Pro Leu Asn Ser Pro Phe Met Ala 
385                 390                 395                 400 


Ser Cys Arg Ser Leu Leu Leu Gly Gly Asp Ser Ser Glu Asp Gly His 
                405                 410                 415     


Tyr Phe Arg Gly His Leu Gly Thr Leu Val Phe Trp Ser Thr Ala Leu 
            420                 425                 430         


Pro Gln Ser His Phe Gln His Ser Ser Gln His Ser Ser Gly Glu Glu 
        435                 440                 445             


Glu Ala Thr Asp Leu Val Leu Thr Ala Ser Phe Glu Pro Val Asn Thr 
    450                 455                 460                 


Glu Trp Val Pro Phe Arg Asp Glu Lys Tyr Pro Arg Leu Glu Val Leu 
465                 470                 475                 480 


Gln Gly Phe Glu Pro Glu Pro Glu Ile Leu Ser Pro Leu Gln Pro Pro 
                485                 490                 495     


Leu Cys Gly Gln Thr Val Cys Asp Asn Val Glu Leu Ile Ser Gln Tyr 
            500                 505                 510         


Asn Gly Tyr Trp Pro Leu Arg Gly Glu Lys Val Ile Arg Tyr Gln Val 
        515                 520                 525             


Val Asn Ile Cys Asp Asp Glu Gly Leu Asn Pro Ile Val Ser Glu Glu 
    530                 535                 540                 


Gln Ile Arg Leu Gln His Glu Ala Leu Asn Glu Ala Phe Ser Arg Tyr 
545                 550                 555                 560 


Asn Ile Ser Trp Gln Leu Asn Val His Gln Val His Asn Ser Thr Leu 
                565                 570                 575     


Arg His Arg Val Val Leu Val Asn Cys Glu Pro Ser Lys Ile Gly Asn 
            580                 585                 590         


Asp His Cys Asp Pro Glu Cys Glu His Pro Leu Thr Gly Tyr Asp Gly 
        595                 600                 605             


Gly Asp Cys Arg Leu Gln Gly Arg Cys Tyr Ser Trp Asn Arg Arg Asp 
    610                 615                 620                 


Gly Leu Cys His Val Glu Cys Asn Asn Met Leu Asn Asp Phe Asp Asp 
625                 630                 635                 640 


Gly Asp Cys Cys Asp Pro Gln Val Ala Asp Val Arg Lys Thr Cys Phe 
                645                 650                 655     


Asp Pro Asp Ser Pro Lys Arg Ala Tyr Met Ser Val Lys Glu Leu Lys 
            660                 665                 670         


Glu Ala Leu Gln Leu Asn Ser Thr His Phe Leu Asn Ile Tyr Phe Ala 
        675                 680                 685             


Ser Ser Val Arg Glu Asp Leu Ala Gly Ala Ala Thr Trp Pro Trp Asp 
    690                 695                 700                 


Lys Asp Ala Val Thr His Leu Gly Gly Ile Val Leu Ser Pro Ala Tyr 
705                 710                 715                 720 


Tyr Gly Met Pro Gly His Thr Asp Thr Met Ile His Glu Val Gly His 
                725                 730                 735     


Val Leu Gly Leu Tyr His Val Phe Lys Gly Val Ser Glu Arg Glu Ser 
            740                 745                 750         


Cys Asn Asp Pro Cys Lys Glu Thr Val Pro Ser Met Glu Thr Gly Asp 
        755                 760                 765             


Leu Cys Ala Asp Thr Ala Pro Thr Pro Lys Ser Glu Leu Cys Arg Glu 
    770                 775                 780                 


Pro Glu Pro Thr Ser Asp Thr Cys Gly Phe Thr Arg Phe Pro Gly Ala 
785                 790                 795                 800 


Pro Phe Thr Asn Tyr Met Ser Tyr Thr Gly Ile Thr Thr Val Leu Phe 
                805                 810                 815     


Cys Phe Leu Leu Arg Ile His Gly Gly Leu 
            820                 825     


<210>  349
<211>  7331
<212>  DNA
<213>  Homosapiens

<400>  349
gctccgggaa acaaagaatc cggggctctc cagacatcag agcttaaacc caggactctg     60

caagcggcat ctcattccgg ggtccagggc tctcccggct ctccatcccc tccctaacct    120

cccccgcctc ccgcgctcgc tccctcgctc cctccccgct cgcttcctcc cccaccatcg    180

cagcgctagg aggaaggcgg ccggggctca agatggcttt agccgggctc tgcgccctgc    240

tcgcctgctg ctgggggccg gcggcggtgc tggccacggc cgccggcgac gtggatccat    300

ccaaggagct ggagtgcaag ctcaaaagca tcacggtgtc ggcactgccc ttcctgcgcg    360

agaacgacct gagcatcatg cacagcccct cggcctcgga gcccaagctc ctcttctcgg    420

tgcgcaacga cttcccggga gaaatggtcg tggtggacga cctggagaac acggagctgc    480

cctacttcgt gctggagatc tcagggaaca cagaggatat ccctttggtg cgctggaggc    540

agcagtggct ggagaatggc actttgcttt ttcacattca tcaccaagat ggtgccccaa    600

gccttcctgg acaagacccc actgaagaac cccaacatga gtcggcagaa gaggagctga    660

ggatcctcca catctcagtc atgggtggca tgatcgctct gctgctgtcc atcttgtgcc    720

tggtgatgat cctgtatact cgccggcgct ggtgcaaacg ccgccgggtc ccgcagcccc    780

agaagagtgc cagtgctgag gcagccaatg agattcacta cattccttct gtgctgatcg    840

gcgggcacgg acgggagagc ctgcgcaatg cccgcgtgca gggccacaac tccagtggca    900

ccctgagcat ccgggagaca cctatcctgg acggctatga gtatgacatc actgatctgc    960

gccaccatct gcagagggag tgcatgaacg gaggggagga ctttgccagc caggtcacgc   1020

gcaccctcga ctccctgcag ggctgcaatg aaaagtcggg gatggacctc acaccaggaa   1080

gtgacaatgc caagctgtca ctgatgaaca agtataaaga taatattata gccactagcc   1140

ctgtggactc caaccaccag caagccaccc ttctctctca cacctccagc agccagagaa   1200

agcggatcaa caacaaagca agagctggtt ccgccttctt gaaccctgaa ggggattctg   1260

gcacagaggc agaaaacgac ccccagctga ccttttacac ggatccttca aggagcagga   1320

ggcgtagtag agtgggttct ccccgaagtc ctgtgaataa gaccaccttg accctgatca   1380

gcatcaccag ctgtgtgatt ggcctcgtgt gctcctctca cgtcaactgc cctctcgttg   1440

tcaagatcac cctgcatgtc cctgagcacc tgattgctga tgggagccgc ttcatcttgc   1500

tggaggggag ccagctggat gccagtgact ggctgaaccc tgcccaagtg gttctcttct   1560

ctcagcagaa ctccagcgga ccctgggcca tggacctctg tgcccggcgg ctcctggacc   1620

cctgtgaaca ccaatgtgac cccgaaactg gggaatgcct ctgctatgaa ggctacatga   1680

aggatccagt acataagcac ctttgcattc ggaacgaatg ggggacaaac caggggccat   1740

ggccttacac aatatttcag cgaggctttg acctggtttt gggagagcag ccctctgata   1800

aaatatttag attcacctac actcttgggg agggcatgtg gttgcccctc agcaagagct   1860

ttgtgattcc accagccgaa ctggccatca atccatcagc aaagtgcaag acggacatga   1920

ctgtgatgga ggatgctgtg gaggtcagag aggagctgat gacttcatcc tccttcgaca   1980

gcctggaggt tctcttagat tcctttgggc cggtgcgcga ctgcagcaaa gataacgggg   2040

gctgcagtaa gaatttccgc tgtatttcag atcgcaagct ggactccact ggttgcgtgt   2100

gcccatctgg actcagtccc atgaaggaca gctctggctg ctatgaccgc cacatcgggg   2160

tggactgttc cgacggcttc aacggcggct gtgagcagct gtgcctccag cagatggcgc   2220

ccttcccgga cgaccccacc ttgtataaca tcctcatgtt ctgtgggtgc atcgaggact   2280

acaagcttgg tgtggatgga cgctcttgcc aactcatcac ggagacctgt ccagagggaa   2340

gtgactgtgg ggaaagcagg gagcttccca tgaaccagac cctctttggg gagatgttct   2400

ttggttacaa caaccattcc aaggaagtgg ctgccggaca ggtgctgaaa ggaacattca   2460

ggcaaaacaa ctttgctcgt ggtttagacc agcaactgcc agatggtctt gtggtggcca   2520

ctgtgcccct ggagaatcaa tgcctagagg agatctcgga gcccacccct gaccctgact   2580

tcctgactgg gatggtgaac ttcagtgaag tgtctgggta ccctgtgctg cagcactgga   2640

aggtccggtc tgtgatgtac cacatcaaac tcaaccaagt ggccatctct caggccctca   2700

gcaatgctct ccactcgctg gatggggcta catctcgtgc agattttgtg gcgctgttgg   2760

accagttcgg caaccattac atccaggaag ctatctacgg ctttgaggag tcctgttcta   2820

tctggtaccc aaacaagcag gtccagcggc gactctggct ggagtatgaa gacatcagta   2880

aaggcaactc cccatcagat gagtctgagg agcgggaaag agaccccaag gtgctgacat   2940

tcccagaata catcaccagc ttgtcagact ccggcaccaa gcacatggcg gctggagtcc   3000

gcatggagtg ccacagcaag ggacgatgcc cctcgtcctg ccccctgtgt catgtgacat   3060

ccagccctga cacccctgct gagccggttc tgctggaggt gaccaaagca gcccccatct   3120

atgaactagt gaccaacaac cagacccaga ggctcttgca ggaggctacc atgagctctc   3180

tctggtgctc agggactgga gatgtcatcg aggactggtg tcgatgtgac tccactgctt   3240

ttggagctga tggactcccc acctgtgcgc ctctcccaca gcctgtgctg agactctcca   3300

cggttcacga gcccagcagc actcttgtgg tcctggagtg ggaacactca gagccaccaa   3360

tcggggtgca gattgtagat tacctcctcc gtcaagagaa agtcactgac aggatggacc   3420

actccaaagt ggagacagaa acagtgctga gctttgtgga cgacatcatc tctggagcaa   3480

agtctccttg tgcaatgcca tctcaggtgc cggacaagca gctcaccacc atctctctga   3540

tcatacgatg cctggaacct gacaccattt acatgttcac gctgtgggga gtggacaaca   3600

caggacggcg ctccaggcca agcgacgtga tcgtgaagac cccatgcccc gtggtggatg   3660

atgtcaaggc tcaagaaata gcagacaaga tctacaatct cttcaatggc tacactagtg   3720

ggaaggagca gcagaccgcc tacaacaccc tcctggatct gggttccccc accttacacc   3780

gggtcctcta ccactataac cagcactatg agagttttgg ggaattcacc tggcgatgtg   3840

aggatgagtt aggtcccagg aaagctggtc tcatcctttc ccagcttggg gacctcagca   3900

gttggtgcaa tggactcctt caggaaccca agataagctt gcggcgcagc tcactcaagt   3960

acctggggtg ccgctacagc gagatcaaac cctacggact tgactgggcg gagctcagcc   4020

gggacctcag gaagacgtgt gaggagcaga ccctgagtat cccctacaac gactatgggg   4080

acagcaaaga gatctagcac cataaggcca gggagctgct gccagaatga agtaggaaag   4140

aggagggatc catctgggtt ggtctgtgga tttttaatat tttttaatgg aacatgaaaa   4200

cctccacagc aacatcgaaa ccagggagaa agtgatcctt gctccctgca gaacttcttc   4260

agtatgatgt tctccatctg catgattggg aaatctgcca gccagtggct tcatgcagtg   4320

ccatatttct ttagaggatt actttggggt ttgctttgcc attaatttgt tccattcatt   4380

tttttttccc tgagaagttt accaaaatgc tcaagagctc tgccgtgctc cccatgaaaa   4440

gtctattaag taggcaccct gtgctcactc agttcctaaa tccattgcaa ctgggagcag   4500

aggtgaggcc agaaagttgt taggcctgcc gcaggcccca ccctcaagca ttcctcagga   4560

agcgtctcac tctgggagcc ttggccctgc tcacagagag agacaataga aaattgagga   4620

aggtggccct tgtctgtgtc tcctggtttt cttcctaggc cttgctatca ctatttccat   4680

acccgaaagg tgaaaccagc tttcattata ggccccagtg ggccacttgg gttttgagat   4740

ccttccttat tttaagccag gactgggatt aaatctccct ctgtcagatc tctgtccctt   4800

cctctgaaca acatgatctt tgagagggaa caagatgcca tctgtcaact gcaccttcag   4860

aaaagtctac ctgggagact agttagcagt ccacattcaa gagaagactt ggagtttatt   4920

gttttttaaa aaaaccatgc ttcctttgga tagacttctc cagcctacca atatatatcc   4980

atgtgcctgg attatcttta acccccacac ctcttacctt ggacaggtaa ggcttggccg   5040

atgtctgatt gggaccagga ggggtcaaca ctttcatatc agtgttacag tgaactaaag   5100

ctattattga tcacaaaaaa cttctgttca tccccacctt gctaaatttg cttgtgttgc   5160

tagttttgca aatcgtttct ctgatgacca taagcaggag gattccacca tggtcactgc   5220

ccatccagtc acagggattc tgtgtaggga agcaccactg attgcagtta acatctagag   5280

tgttgtttcc atcccactgc ccaagcattg gcatggtcat gaatggtggc ccagccaaca   5340

ggaagcccag cctttcagaa agagcctggc aaggccctgt tgactagcaa tggccttagc   5400

tgtcccacac aactcagtgg cctgaacaca caccttcagc caccatgcct ttgaccaggg   5460

ctcctcatct ggaaacatat gagaaaggtc agcaaacaga tgcaagacct ataaggctag   5520

tcattgagct atattggttt tttttctaaa tagtagtagt gacagataac atttattgag   5580

tgcttgctgt atgccaggcg ctgatgtaag cactttaggt atcattgaat tctcacagca   5640

actcctgagg aaagtgctat tcttgtctcc attttagtgt tgaggaaaac gaggcaaaga   5700

gaggttatac aacttgcctc aaatcccttg tgcactgtaa ctcacactga gtttcagtgt   5760

gatttcaggc tgttggtctc cagggcacag gatcttagct actctgggat acccagttct   5820

gttttcagta tcatctggca cacaactgtc caagctctca gccccacagg gaacctgccc   5880

agagagcttt acctttccca agcatctgtg gcatggacat gtcctctgtg cagtggaagg   5940

aggaggggcg aaagtacgcc cttagccttt ggagctagag cacccttggg acccctagtt   6000

ccactgcaca tggccctcct ccccaccctc atgactggga aggaagcctg tgatgaggct   6060

gagataaagc acagggtggt ttcactctcc tctctccttc tttccaaaca ctgaaggatt   6120

tatttcaaac tctctaatgc acctgcctca gagattcccc tactttcaaa gcaaagatca   6180

gcagaaaaat tggctgtccc acctgtggca aatgctggag cctcagttaa agtgcctcaa   6240

ggggcaaata tttcaccatt gccagagaag atgtgacagg ccaatcagac agggcccaga   6300

gcatctcttt gctgctactg ttttgccatc cttctattca tatctgtgca gaacacggtg   6360

ttttaagctt gagtgaaagg agggtgaggc tgccgatgcc ttcctgccca gaagtggatg   6420

atgtgggagt tgacaggcca gggagagggt gaagcaggta tcagagtcac tcctctgtac   6480

cctctccttc tgtttttatt ttaggcacac tatcttcctc tctcctatct ttccctcaat   6540

ctcccaagtt cctctacctt ctttatcttt gtcttttact tcttctttct gtgaccctcc   6600

ttttttggcc tcctctttcc ccaagacttt cttcctcctg tttctcgttg agttctcccc   6660

actgaatgtg tgtatgtatg tacacacaca cacacgtgtg cacacacaat gcacacaact   6720

cctatgactg gctcctactt acattcaagt taaaaaggct gatatgaaca gggcagggga   6780

aaatcttagg atggttgtac aattgactgg aggatttttt ccccttggaa gacactattg   6840

atctcaacct gctgactttt cctaatgctt acctgaagga acccatcctg gctagaaagg   6900

gtgatggtac tggaccggta ttcaaccttg agttttcaag ctgccaaaca ggtcttaagg   6960

gaggtgctta tatcccacca acactctccc agctcccatg tccccaagac ctctggagtt   7020

tcctcttgaa tgtacatgaa ccactgtaat agcattagac ttttaattga gtgtgcaatc   7080

gttttccatg gagtttggtc cgttcattat tttttagtta actacacttc ttgatattca   7140

aatgttctat taaaaaaact gagtatgaag aaaaacactt tactactgca gaaggaagaa   7200

agaatataat atgaccatct tcaggtataa cagtgttgtt taaaagagaa ttattgtatg   7260

attataaaag atgaaataat taactgaata ataaaacaaa gctattagta agcaaaaaaa   7320

aaaaaaaaaa a                                                        7331


<210>  350
<211>  1294
<212>  PRT
<213>  Homosapiens

<400>  350

Met Ala Leu Ala Gly Leu Cys Ala Leu Leu Ala Cys Cys Trp Gly Pro 
1               5                   10                  15      


Ala Ala Val Leu Ala Thr Ala Ala Gly Asp Val Asp Pro Ser Lys Glu 
            20                  25                  30          


Leu Glu Cys Lys Leu Lys Ser Ile Thr Val Ser Ala Leu Pro Phe Leu 
        35                  40                  45              


Arg Glu Asn Asp Leu Ser Ile Met His Ser Pro Ser Ala Ser Glu Pro 
    50                  55                  60                  


Lys Leu Leu Phe Ser Val Arg Asn Asp Phe Pro Gly Glu Met Val Val 
65                  70                  75                  80  


Val Asp Asp Leu Glu Asn Thr Glu Leu Pro Tyr Phe Val Leu Glu Ile 
                85                  90                  95      


Ser Gly Asn Thr Glu Asp Ile Pro Leu Val Arg Trp Arg Gln Gln Trp 
            100                 105                 110         


Leu Glu Asn Gly Thr Leu Leu Phe His Ile His His Gln Asp Gly Ala 
        115                 120                 125             


Pro Ser Leu Pro Gly Gln Asp Pro Thr Glu Glu Pro Gln His Glu Ser 
    130                 135                 140                 


Ala Glu Glu Glu Leu Arg Ile Leu His Ile Ser Val Met Gly Gly Met 
145                 150                 155                 160 


Ile Ala Leu Leu Leu Ser Ile Leu Cys Leu Val Met Ile Leu Tyr Thr 
                165                 170                 175     


Arg Arg Arg Trp Cys Lys Arg Arg Arg Val Pro Gln Pro Gln Lys Ser 
            180                 185                 190         


Ala Ser Ala Glu Ala Ala Asn Glu Ile His Tyr Ile Pro Ser Val Leu 
        195                 200                 205             


Ile Gly Gly His Gly Arg Glu Ser Leu Arg Asn Ala Arg Val Gln Gly 
    210                 215                 220                 


His Asn Ser Ser Gly Thr Leu Ser Ile Arg Glu Thr Pro Ile Leu Asp 
225                 230                 235                 240 


Gly Tyr Glu Tyr Asp Ile Thr Asp Leu Arg His His Leu Gln Arg Glu 
                245                 250                 255     


Cys Met Asn Gly Gly Glu Asp Phe Ala Ser Gln Val Thr Arg Thr Leu 
            260                 265                 270         


Asp Ser Leu Gln Gly Cys Asn Glu Lys Ser Gly Met Asp Leu Thr Pro 
        275                 280                 285             


Gly Ser Asp Asn Ala Lys Leu Ser Leu Met Asn Lys Tyr Lys Asp Asn 
    290                 295                 300                 


Ile Ile Ala Thr Ser Pro Val Asp Ser Asn His Gln Gln Ala Thr Leu 
305                 310                 315                 320 


Leu Ser His Thr Ser Ser Ser Gln Arg Lys Arg Ile Asn Asn Lys Ala 
                325                 330                 335     


Arg Ala Gly Ser Ala Phe Leu Asn Pro Glu Gly Asp Ser Gly Thr Glu 
            340                 345                 350         


Ala Glu Asn Asp Pro Gln Leu Thr Phe Tyr Thr Asp Pro Ser Arg Ser 
        355                 360                 365             


Arg Arg Arg Ser Arg Val Gly Ser Pro Arg Ser Pro Val Asn Lys Thr 
    370                 375                 380                 


Thr Leu Thr Leu Ile Ser Ile Thr Ser Cys Val Ile Gly Leu Val Cys 
385                 390                 395                 400 


Ser Ser His Val Asn Cys Pro Leu Val Val Lys Ile Thr Leu His Val 
                405                 410                 415     


Pro Glu His Leu Ile Ala Asp Gly Ser Arg Phe Ile Leu Leu Glu Gly 
            420                 425                 430         


Ser Gln Leu Asp Ala Ser Asp Trp Leu Asn Pro Ala Gln Val Val Leu 
        435                 440                 445             


Phe Ser Gln Gln Asn Ser Ser Gly Pro Trp Ala Met Asp Leu Cys Ala 
    450                 455                 460                 


Arg Arg Leu Leu Asp Pro Cys Glu His Gln Cys Asp Pro Glu Thr Gly 
465                 470                 475                 480 


Glu Cys Leu Cys Tyr Glu Gly Tyr Met Lys Asp Pro Val His Lys His 
                485                 490                 495     


Leu Cys Ile Arg Asn Glu Trp Gly Thr Asn Gln Gly Pro Trp Pro Tyr 
            500                 505                 510         


Thr Ile Phe Gln Arg Gly Phe Asp Leu Val Leu Gly Glu Gln Pro Ser 
        515                 520                 525             


Asp Lys Ile Phe Arg Phe Thr Tyr Thr Leu Gly Glu Gly Met Trp Leu 
    530                 535                 540                 


Pro Leu Ser Lys Ser Phe Val Ile Pro Pro Ala Glu Leu Ala Ile Asn 
545                 550                 555                 560 


Pro Ser Ala Lys Cys Lys Thr Asp Met Thr Val Met Glu Asp Ala Val 
                565                 570                 575     


Glu Val Arg Glu Glu Leu Met Thr Ser Ser Ser Phe Asp Ser Leu Glu 
            580                 585                 590         


Val Leu Leu Asp Ser Phe Gly Pro Val Arg Asp Cys Ser Lys Asp Asn 
        595                 600                 605             


Gly Gly Cys Ser Lys Asn Phe Arg Cys Ile Ser Asp Arg Lys Leu Asp 
    610                 615                 620                 


Ser Thr Gly Cys Val Cys Pro Ser Gly Leu Ser Pro Met Lys Asp Ser 
625                 630                 635                 640 


Ser Gly Cys Tyr Asp Arg His Ile Gly Val Asp Cys Ser Asp Gly Phe 
                645                 650                 655     


Asn Gly Gly Cys Glu Gln Leu Cys Leu Gln Gln Met Ala Pro Phe Pro 
            660                 665                 670         


Asp Asp Pro Thr Leu Tyr Asn Ile Leu Met Phe Cys Gly Cys Ile Glu 
        675                 680                 685             


Asp Tyr Lys Leu Gly Val Asp Gly Arg Ser Cys Gln Leu Ile Thr Glu 
    690                 695                 700                 


Thr Cys Pro Glu Gly Ser Asp Cys Gly Glu Ser Arg Glu Leu Pro Met 
705                 710                 715                 720 


Asn Gln Thr Leu Phe Gly Glu Met Phe Phe Gly Tyr Asn Asn His Ser 
                725                 730                 735     


Lys Glu Val Ala Ala Gly Gln Val Leu Lys Gly Thr Phe Arg Gln Asn 
            740                 745                 750         


Asn Phe Ala Arg Gly Leu Asp Gln Gln Leu Pro Asp Gly Leu Val Val 
        755                 760                 765             


Ala Thr Val Pro Leu Glu Asn Gln Cys Leu Glu Glu Ile Ser Glu Pro 
    770                 775                 780                 


Thr Pro Asp Pro Asp Phe Leu Thr Gly Met Val Asn Phe Ser Glu Val 
785                 790                 795                 800 


Ser Gly Tyr Pro Val Leu Gln His Trp Lys Val Arg Ser Val Met Tyr 
                805                 810                 815     


His Ile Lys Leu Asn Gln Val Ala Ile Ser Gln Ala Leu Ser Asn Ala 
            820                 825                 830         


Leu His Ser Leu Asp Gly Ala Thr Ser Arg Ala Asp Phe Val Ala Leu 
        835                 840                 845             


Leu Asp Gln Phe Gly Asn His Tyr Ile Gln Glu Ala Ile Tyr Gly Phe 
    850                 855                 860                 


Glu Glu Ser Cys Ser Ile Trp Tyr Pro Asn Lys Gln Val Gln Arg Arg 
865                 870                 875                 880 


Leu Trp Leu Glu Tyr Glu Asp Ile Ser Lys Gly Asn Ser Pro Ser Asp 
                885                 890                 895     


Glu Ser Glu Glu Arg Glu Arg Asp Pro Lys Val Leu Thr Phe Pro Glu 
            900                 905                 910         


Tyr Ile Thr Ser Leu Ser Asp Ser Gly Thr Lys His Met Ala Ala Gly 
        915                 920                 925             


Val Arg Met Glu Cys His Ser Lys Gly Arg Cys Pro Ser Ser Cys Pro 
    930                 935                 940                 


Leu Cys His Val Thr Ser Ser Pro Asp Thr Pro Ala Glu Pro Val Leu 
945                 950                 955                 960 


Leu Glu Val Thr Lys Ala Ala Pro Ile Tyr Glu Leu Val Thr Asn Asn 
                965                 970                 975     


Gln Thr Gln Arg Leu Leu Gln Glu Ala Thr Met Ser Ser Leu Trp Cys 
            980                 985                 990         


Ser Gly Thr Gly Asp Val Ile Glu  Asp Trp Cys Arg Cys  Asp Ser Thr 
        995                 1000                 1005             


Ala Phe  Gly Ala Asp Gly Leu  Pro Thr Cys Ala Pro  Leu Pro Gln 
    1010                 1015                 1020             


Pro Val  Leu Arg Leu Ser Thr  Val His Glu Pro Ser  Ser Thr Leu 
    1025                 1030                 1035             


Val Val  Leu Glu Trp Glu His  Ser Glu Pro Pro Ile  Gly Val Gln 
    1040                 1045                 1050             


Ile Val  Asp Tyr Leu Leu Arg  Gln Glu Lys Val Thr  Asp Arg Met 
    1055                 1060                 1065             


Asp His  Ser Lys Val Glu Thr  Glu Thr Val Leu Ser  Phe Val Asp 
    1070                 1075                 1080             


Asp Ile  Ile Ser Gly Ala Lys  Ser Pro Cys Ala Met  Pro Ser Gln 
    1085                 1090                 1095             


Val Pro  Asp Lys Gln Leu Thr  Thr Ile Ser Leu Ile  Ile Arg Cys 
    1100                 1105                 1110             


Leu Glu  Pro Asp Thr Ile Tyr  Met Phe Thr Leu Trp  Gly Val Asp 
    1115                 1120                 1125             


Asn Thr  Gly Arg Arg Ser Arg  Pro Ser Asp Val Ile  Val Lys Thr 
    1130                 1135                 1140             


Pro Cys  Pro Val Val Asp Asp  Val Lys Ala Gln Glu  Ile Ala Asp 
    1145                 1150                 1155             


Lys Ile  Tyr Asn Leu Phe Asn  Gly Tyr Thr Ser Gly  Lys Glu Gln 
    1160                 1165                 1170             


Gln Thr  Ala Tyr Asn Thr Leu  Leu Asp Leu Gly Ser  Pro Thr Leu 
    1175                 1180                 1185             


His Arg  Val Leu Tyr His Tyr  Asn Gln His Tyr Glu  Ser Phe Gly 
    1190                 1195                 1200             


Glu Phe  Thr Trp Arg Cys Glu  Asp Glu Leu Gly Pro  Arg Lys Ala 
    1205                 1210                 1215             


Gly Leu  Ile Leu Ser Gln Leu  Gly Asp Leu Ser Ser  Trp Cys Asn 
    1220                 1225                 1230             


Gly Leu  Leu Gln Glu Pro Lys  Ile Ser Leu Arg Arg  Ser Ser Leu 
    1235                 1240                 1245             


Lys Tyr  Leu Gly Cys Arg Tyr  Ser Glu Ile Lys Pro  Tyr Gly Leu 
    1250                 1255                 1260             


Asp Trp  Ala Glu Leu Ser Arg  Asp Leu Arg Lys Thr  Cys Glu Glu 
    1265                 1270                 1275             


Gln Thr  Leu Ser Ile Pro Tyr  Asn Asp Tyr Gly Asp  Ser Lys Glu 
    1280                 1285                 1290             


Ile 
    


<210>  351
<211>  3914
<212>  DNA
<213>  Homosapiens

<400>  351
gctccgggaa acaaagaatc cggggctctc cagacatcag agcttaaacc caggactctg     60

caagcggcat ctcattccgg ggtccagggc tctcccggct ctccatcccc tccctaacct    120

cccccgcctc ccgcgctcgc tccctcgctc cctccccgct cgcttcctcc cccaccatcg    180

cagcgctagg aggaaggcgg ccggggctca agatggcttt agccgggctc tgcgccctgc    240

tcgcctgctg ctgggggccg gcggcggtgc tggccacggc cgccggcgac gtggatccat    300

ccaaggagct ggagtgcaag ctcaaaagca tcacggtgtc ggcactgccc ttcctgcgcg    360

agaacgacct gagcatcatg cacagcccct cggcctcgga gcccaagctc ctcttctcgg    420

tgcgcaacga cttcccggga gaaatggtcg tggtggacga cctggagaac acggagctgc    480

cctacttcgt gctggagatc tcagggaaca cagaggatat ccctttggtg cgctggaggc    540

agcagtggct ggagaatggc actttgcttt ttcacattca tcaccaagat ggtgccccaa    600

gccttcctgg acaagacccc actgaagaac cccaacatga gtcggcagaa gaggagctga    660

ggatcctcca catctcagtc atgggtggca tgatcgctct gctgctgtcc atcttgtgcc    720

tggtgatgat cctgtatact cgccggcgct ggtgcaaacg ccgccgggtc ccgcagcccc    780

agaagagtgc cagtgctgag gcagccaatg agattcacta cattccttct gtgctgatcg    840

gcgggcacgg acgggagagc ctgcgcaatg cccgcgtgca gggccacaac tccagtggca    900

ccctgagcat ccgggagaca cctatcctgg acggctatga gtatgacatc actgatctgc    960

gccaccatct gcagagggag tgcatgaacg gaggggagga ctttgccagc caggtcacgc   1020

gcaccctcga ctccctgcag ggctgcaatg aaaagtcggg gatggacctc acaccaggaa   1080

gtgacaatgc caagctgtca ctgatgaaca agtataaaga taatattata gccactagcc   1140

ctgtggactc caaccaccag caagccaccc ttctctctca cacctccagc agccagagaa   1200

agcggatcaa caacaaagca agagctggtt ccgccttctt gaaccctgaa ggggattctg   1260

gcacagaggc agaaaacgac ccccagctga ccttttacac ggatccttca aggagcagga   1320

ggcgtagtag agtgggttct ccccgaagtc ctgtgaataa gaccaccttg accctgatca   1380

gcatcaccag ctgtgtgatt ggcctcgtgt gctcctctca cgtcaactgc cctctcgttg   1440

tcaagatcac cctgcatgtc cctgagcacc tgattgctga tgggagccgc ttcatcttgc   1500

tggaggggag ccagctggat gccagtgact ggctgaaccc tgcccaagtg gttctcttct   1560

ctcagcagaa ctccagcgga ccctgggcca tggacctctg tgcccggcgg ctcctggacc   1620

cctgtgaaca ccaatgtgac cccgaaactg gggaatgcct ctgctatgaa ggctacatga   1680

aggatccagt acataagcac ctttgcattc ggaacgaatg ggggacaaac caggggccat   1740

ggccttacac aatatttcag cgaggctttg acctggtttt gggagagcag ccctctgata   1800

aaatatttag attcacctac actcttgggg agggcatgtg gttgcccctc agcaagagct   1860

ttgtgattcc accagccgaa ctggccatca atccatcagc aaagtgcaag acggacatga   1920

ctgtgatgga ggatgctgtg gaggtcagag aggagctgat gacttcatcc tccttcgaca   1980

gcctggaggt tctcttagat tcctttgggc cggtgcgcga ctgcagcaaa gataacgggg   2040

gctgcagtaa gaatttccgc tgtatttcag atcgcaagct ggactccact ggttgcgtgt   2100

gcccatctgg actcagtccc atgaaggaca gctctggctg ctatgaccgc cacatcgggg   2160

tggactgttc cgacggcttc aacggcggct gtgagcagct gtgcctccag cagatggcgc   2220

ccttcccgga cgaccccacc ttgtataaca tcctcatgtt ctgtgggtgc atcgaggact   2280

acaagcttgg tgtggatgga cgctcttgcc aactcatcac ggagacctgt ccagagggaa   2340

gtgactgtgg ggaaagcagg gagcttccca tgaaccagac cctctttggg gagatgttct   2400

ttggttacaa caaccattcc aaggaagtgg ctgccggaca ggtgctgaaa ggaacattca   2460

ggcaaaacaa ctttgctcgt ggtttagacc agcaactgcc agatggtctt gtggtggcca   2520

ctgtgcccct ggagaatcaa tgcctagagg agatctcgga gcccacccct gaccctgact   2580

tcctgactgg gatggtgaac ttcagtgaag tgtctgggta ccctgtgctg cagcactgga   2640

aggtccggtc tgtgatgtac cacatcaaac tcaaccaagt ggccatctct caggccctca   2700

gcaatgctct ccactcgctg gatggggcta catctcgtgc agattttgtg gcgctgttgg   2760

accagttcgg caaccattac atccaggaag ctatctacgg ctttgaggag tcctgttcta   2820

tctggtaccc aaacaagcag gtccagcggc gactctggct ggagtatgaa gacatcagta   2880

aaggcaactc cccatcagat gagtctgagg agcgggaaag agaccccaag gtgctgacat   2940

tcccagaata catcaccagc ttgtcagact ccggcaccaa gcacatggcg gctggagtcc   3000

gcatggagtg ccacagcaag ggacgatgcc cctcgtcctg ccccctgtgt catgtgacat   3060

ccagccctga cacccctgct gagccggttc tgctggaggt gaccaaagca gcccccatct   3120

atgaactagt gaccaacaac cagacccaga ggctcttgca ggaggctacc atgagctctc   3180

tctggtgctc agggactgga gatgtcatcg aggactggtg tcgatgtgac tccactgctt   3240

ttggagctga tggactcccc acctgtgcgc ctctcccaca gcctgtgctg agactctcca   3300

cggttcacga gcccagcagc actcttgtgg tcctggagtg ggaacactca gagccaccaa   3360

tcggggtgca gattgtagat tacctcctcc gtcaagagaa agtcactgac aggatggacc   3420

actccaaagt ggagacagaa acagtgctga gctttgtgga cgacatcatc tctggagcaa   3480

agtctccttg tgcaatgcca tctcaggtgc cggacaagca gctcaccacc atctctctga   3540

tcatacgatg cctggaacct gacaccattt acatgttcac gctgtgggga gtggacaaca   3600

caggacggcg ctccaggcca agcgacgtga tcgtgaagac cccatgcccc gtggtggatg   3660

atgtcaaggc tcaagaaata gcagacaaga tctacaatct cttcaatggc tacactagtg   3720

ggaaggagca gcagaccgcc tacaacaccc tcctggatct gggttccccc accttacacc   3780

gggtcctcta ccactataac cagcactatg agagttttgg ggaattcacc tggcgatgtg   3840

aggatgagtt aggtcccagg taatcaataa actaagtcaa cccttaaaaa aaaaaaaaaa   3900

aaaaaaaaaa aaaa                                                     3914


<210>  352
<211>  1216
<212>  PRT
<213>  Homosapiens

<400>  352

Met Ala Leu Ala Gly Leu Cys Ala Leu Leu Ala Cys Cys Trp Gly Pro 
1               5                   10                  15      


Ala Ala Val Leu Ala Thr Ala Ala Gly Asp Val Asp Pro Ser Lys Glu 
            20                  25                  30          


Leu Glu Cys Lys Leu Lys Ser Ile Thr Val Ser Ala Leu Pro Phe Leu 
        35                  40                  45              


Arg Glu Asn Asp Leu Ser Ile Met His Ser Pro Ser Ala Ser Glu Pro 
    50                  55                  60                  


Lys Leu Leu Phe Ser Val Arg Asn Asp Phe Pro Gly Glu Met Val Val 
65                  70                  75                  80  


Val Asp Asp Leu Glu Asn Thr Glu Leu Pro Tyr Phe Val Leu Glu Ile 
                85                  90                  95      


Ser Gly Asn Thr Glu Asp Ile Pro Leu Val Arg Trp Arg Gln Gln Trp 
            100                 105                 110         


Leu Glu Asn Gly Thr Leu Leu Phe His Ile His His Gln Asp Gly Ala 
        115                 120                 125             


Pro Ser Leu Pro Gly Gln Asp Pro Thr Glu Glu Pro Gln His Glu Ser 
    130                 135                 140                 


Ala Glu Glu Glu Leu Arg Ile Leu His Ile Ser Val Met Gly Gly Met 
145                 150                 155                 160 


Ile Ala Leu Leu Leu Ser Ile Leu Cys Leu Val Met Ile Leu Tyr Thr 
                165                 170                 175     


Arg Arg Arg Trp Cys Lys Arg Arg Arg Val Pro Gln Pro Gln Lys Ser 
            180                 185                 190         


Ala Ser Ala Glu Ala Ala Asn Glu Ile His Tyr Ile Pro Ser Val Leu 
        195                 200                 205             


Ile Gly Gly His Gly Arg Glu Ser Leu Arg Asn Ala Arg Val Gln Gly 
    210                 215                 220                 


His Asn Ser Ser Gly Thr Leu Ser Ile Arg Glu Thr Pro Ile Leu Asp 
225                 230                 235                 240 


Gly Tyr Glu Tyr Asp Ile Thr Asp Leu Arg His His Leu Gln Arg Glu 
                245                 250                 255     


Cys Met Asn Gly Gly Glu Asp Phe Ala Ser Gln Val Thr Arg Thr Leu 
            260                 265                 270         


Asp Ser Leu Gln Gly Cys Asn Glu Lys Ser Gly Met Asp Leu Thr Pro 
        275                 280                 285             


Gly Ser Asp Asn Ala Lys Leu Ser Leu Met Asn Lys Tyr Lys Asp Asn 
    290                 295                 300                 


Ile Ile Ala Thr Ser Pro Val Asp Ser Asn His Gln Gln Ala Thr Leu 
305                 310                 315                 320 


Leu Ser His Thr Ser Ser Ser Gln Arg Lys Arg Ile Asn Asn Lys Ala 
                325                 330                 335     


Arg Ala Gly Ser Ala Phe Leu Asn Pro Glu Gly Asp Ser Gly Thr Glu 
            340                 345                 350         


Ala Glu Asn Asp Pro Gln Leu Thr Phe Tyr Thr Asp Pro Ser Arg Ser 
        355                 360                 365             


Arg Arg Arg Ser Arg Val Gly Ser Pro Arg Ser Pro Val Asn Lys Thr 
    370                 375                 380                 


Thr Leu Thr Leu Ile Ser Ile Thr Ser Cys Val Ile Gly Leu Val Cys 
385                 390                 395                 400 


Ser Ser His Val Asn Cys Pro Leu Val Val Lys Ile Thr Leu His Val 
                405                 410                 415     


Pro Glu His Leu Ile Ala Asp Gly Ser Arg Phe Ile Leu Leu Glu Gly 
            420                 425                 430         


Ser Gln Leu Asp Ala Ser Asp Trp Leu Asn Pro Ala Gln Val Val Leu 
        435                 440                 445             


Phe Ser Gln Gln Asn Ser Ser Gly Pro Trp Ala Met Asp Leu Cys Ala 
    450                 455                 460                 


Arg Arg Leu Leu Asp Pro Cys Glu His Gln Cys Asp Pro Glu Thr Gly 
465                 470                 475                 480 


Glu Cys Leu Cys Tyr Glu Gly Tyr Met Lys Asp Pro Val His Lys His 
                485                 490                 495     


Leu Cys Ile Arg Asn Glu Trp Gly Thr Asn Gln Gly Pro Trp Pro Tyr 
            500                 505                 510         


Thr Ile Phe Gln Arg Gly Phe Asp Leu Val Leu Gly Glu Gln Pro Ser 
        515                 520                 525             


Asp Lys Ile Phe Arg Phe Thr Tyr Thr Leu Gly Glu Gly Met Trp Leu 
    530                 535                 540                 


Pro Leu Ser Lys Ser Phe Val Ile Pro Pro Ala Glu Leu Ala Ile Asn 
545                 550                 555                 560 


Pro Ser Ala Lys Cys Lys Thr Asp Met Thr Val Met Glu Asp Ala Val 
                565                 570                 575     


Glu Val Arg Glu Glu Leu Met Thr Ser Ser Ser Phe Asp Ser Leu Glu 
            580                 585                 590         


Val Leu Leu Asp Ser Phe Gly Pro Val Arg Asp Cys Ser Lys Asp Asn 
        595                 600                 605             


Gly Gly Cys Ser Lys Asn Phe Arg Cys Ile Ser Asp Arg Lys Leu Asp 
    610                 615                 620                 


Ser Thr Gly Cys Val Cys Pro Ser Gly Leu Ser Pro Met Lys Asp Ser 
625                 630                 635                 640 


Ser Gly Cys Tyr Asp Arg His Ile Gly Val Asp Cys Ser Asp Gly Phe 
                645                 650                 655     


Asn Gly Gly Cys Glu Gln Leu Cys Leu Gln Gln Met Ala Pro Phe Pro 
            660                 665                 670         


Asp Asp Pro Thr Leu Tyr Asn Ile Leu Met Phe Cys Gly Cys Ile Glu 
        675                 680                 685             


Asp Tyr Lys Leu Gly Val Asp Gly Arg Ser Cys Gln Leu Ile Thr Glu 
    690                 695                 700                 


Thr Cys Pro Glu Gly Ser Asp Cys Gly Glu Ser Arg Glu Leu Pro Met 
705                 710                 715                 720 


Asn Gln Thr Leu Phe Gly Glu Met Phe Phe Gly Tyr Asn Asn His Ser 
                725                 730                 735     


Lys Glu Val Ala Ala Gly Gln Val Leu Lys Gly Thr Phe Arg Gln Asn 
            740                 745                 750         


Asn Phe Ala Arg Gly Leu Asp Gln Gln Leu Pro Asp Gly Leu Val Val 
        755                 760                 765             


Ala Thr Val Pro Leu Glu Asn Gln Cys Leu Glu Glu Ile Ser Glu Pro 
    770                 775                 780                 


Thr Pro Asp Pro Asp Phe Leu Thr Gly Met Val Asn Phe Ser Glu Val 
785                 790                 795                 800 


Ser Gly Tyr Pro Val Leu Gln His Trp Lys Val Arg Ser Val Met Tyr 
                805                 810                 815     


His Ile Lys Leu Asn Gln Val Ala Ile Ser Gln Ala Leu Ser Asn Ala 
            820                 825                 830         


Leu His Ser Leu Asp Gly Ala Thr Ser Arg Ala Asp Phe Val Ala Leu 
        835                 840                 845             


Leu Asp Gln Phe Gly Asn His Tyr Ile Gln Glu Ala Ile Tyr Gly Phe 
    850                 855                 860                 


Glu Glu Ser Cys Ser Ile Trp Tyr Pro Asn Lys Gln Val Gln Arg Arg 
865                 870                 875                 880 


Leu Trp Leu Glu Tyr Glu Asp Ile Ser Lys Gly Asn Ser Pro Ser Asp 
                885                 890                 895     


Glu Ser Glu Glu Arg Glu Arg Asp Pro Lys Val Leu Thr Phe Pro Glu 
            900                 905                 910         


Tyr Ile Thr Ser Leu Ser Asp Ser Gly Thr Lys His Met Ala Ala Gly 
        915                 920                 925             


Val Arg Met Glu Cys His Ser Lys Gly Arg Cys Pro Ser Ser Cys Pro 
    930                 935                 940                 


Leu Cys His Val Thr Ser Ser Pro Asp Thr Pro Ala Glu Pro Val Leu 
945                 950                 955                 960 


Leu Glu Val Thr Lys Ala Ala Pro Ile Tyr Glu Leu Val Thr Asn Asn 
                965                 970                 975     


Gln Thr Gln Arg Leu Leu Gln Glu Ala Thr Met Ser Ser Leu Trp Cys 
            980                 985                 990         


Ser Gly Thr Gly Asp Val Ile Glu  Asp Trp Cys Arg Cys  Asp Ser Thr 
        995                 1000                 1005             


Ala Phe  Gly Ala Asp Gly Leu  Pro Thr Cys Ala Pro  Leu Pro Gln 
    1010                 1015                 1020             


Pro Val  Leu Arg Leu Ser Thr  Val His Glu Pro Ser  Ser Thr Leu 
    1025                 1030                 1035             


Val Val  Leu Glu Trp Glu His  Ser Glu Pro Pro Ile  Gly Val Gln 
    1040                 1045                 1050             


Ile Val  Asp Tyr Leu Leu Arg  Gln Glu Lys Val Thr  Asp Arg Met 
    1055                 1060                 1065             


Asp His  Ser Lys Val Glu Thr  Glu Thr Val Leu Ser  Phe Val Asp 
    1070                 1075                 1080             


Asp Ile  Ile Ser Gly Ala Lys  Ser Pro Cys Ala Met  Pro Ser Gln 
    1085                 1090                 1095             


Val Pro  Asp Lys Gln Leu Thr  Thr Ile Ser Leu Ile  Ile Arg Cys 
    1100                 1105                 1110             


Leu Glu  Pro Asp Thr Ile Tyr  Met Phe Thr Leu Trp  Gly Val Asp 
    1115                 1120                 1125             


Asn Thr  Gly Arg Arg Ser Arg  Pro Ser Asp Val Ile  Val Lys Thr 
    1130                 1135                 1140             


Pro Cys  Pro Val Val Asp Asp  Val Lys Ala Gln Glu  Ile Ala Asp 
    1145                 1150                 1155             


Lys Ile  Tyr Asn Leu Phe Asn  Gly Tyr Thr Ser Gly  Lys Glu Gln 
    1160                 1165                 1170             


Gln Thr  Ala Tyr Asn Thr Leu  Leu Asp Leu Gly Ser  Pro Thr Leu 
    1175                 1180                 1185             


His Arg  Val Leu Tyr His Tyr  Asn Gln His Tyr Glu  Ser Phe Gly 
    1190                 1195                 1200             


Glu Phe  Thr Trp Arg Cys Glu  Asp Glu Leu Gly Pro  Arg 
    1205                 1210                 1215     


<210>  353
<211>  1552
<212>  DNA
<213>  Homosapiens

<400>  353
acttaatggg ctcaaggtca cctacctgac ctaccagcag ctcaatggcc ttcccaaaga     60

agaaacttca gggtcttgtg gctgcaacca tcacgccaat gactgagaat ggagaaatca    120

acttttcagt aattggtcag tatgtggatt atcttgtgaa agaacaggga gtgaagaaca    180

tttttgtgaa tggcacaaca ggagaaggcc tgtccctgag cgtctcagag cgtcgccagg    240

ttgcagagga gtgggtgaca aaagggaagg acaagctgga tcaggtgata attcacgtag    300

gagcactgag cttgaaggag tcacaggaac tggcccaaca tgcagcagaa ataggagctg    360

atggcatcgc tgtcattgca ccgttcttcc tcaagccatg gaccaaagat atcctgatta    420

atttcctaaa ggaagtggct gctgccgccc ctgccctgcc attttattac tatcacattc    480

ctgccttgac aggggtaaag attcgtgctg aggagttgtt ggatgggatt ctggataaga    540

tccccacctt ccaagggctg aaattcagtg atacagatct cttagacttc gggcaatgtg    600

ttgatcagaa tcgccagcaa cagtttgctt tcctttttgg ggtggatgag caactgttga    660

gtgctctggt gatgggagca actggagcag tgggcagtac ctataactac ctgggaaaaa    720

agacaaacca gatgttggag gcttttgaac aaaaggactt ctctttagcc ctgaactatc    780

agttttgtat ccagagattt atcaactttg ttgtcaaact aggttttgga gtgtcacaga    840

ccaaagccat catgactctg gtctctggga ttccaatggg cccaccccgg cttccactgc    900

agaaagcctc cagggagttt actgatagtg ctgaagctaa actgaagagc ctggatttcc    960

tttctttcac tgatttaaag gatggaaact tggaagctgg tagctagtgc ctctctatca   1020

aatcagggtt tgcaccttga gacataatct accttaaata gtgcattttt ttctcaggga   1080

attttagatg aacttgaata aactctccta gcaaatgaaa tctcacaata agcattgagg   1140

taccttttgt gagccttaaa aagtcttatt ttgtgaaggg gcaaaaactc taggagtcac   1200

aactctcagt cattcatttc acagattttt ttgtggagaa atttctgttt atatggatga   1260

aatggaatca agaggaaaat tgtaattgat taattccatc tgtctttagg agctctcatt   1320

atctcggtct ctggttccta atcctatttt aaagttgtct aattttaaac cactataata   1380

tgtcttcatt ttaataaata ttcatttgga atctaggaaa actctgagct actgcattta   1440

ggcaggcact ttaataccaa actgtaacat gtctcaactg tatacaactc aaaatacacc   1500

agctcatttg gctgctcagt ctaactctag aatggatgct tttgaattca tt           1552


<210>  354
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  354

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Thr Tyr Asn Tyr Leu Gly 
    210                 215                 220                 


Lys Lys Thr Asn Gln Met Leu Glu Ala Phe Glu Gln Lys Asp Phe Ser 
225                 230                 235                 240 


Leu Ala Leu Asn Tyr Gln Phe Cys Ile Gln Arg Phe Ile Asn Phe Val 
                245                 250                 255     


Val Lys Leu Gly Phe Gly Val Ser Gln Thr Lys Ala Ile Met Thr Leu 
            260                 265                 270         


Val Ser Gly Ile Pro Met Gly Pro Pro Arg Leu Pro Leu Gln Lys Ala 
        275                 280                 285             


Ser Arg Glu Phe Thr Asp Ser Ala Glu Ala Lys Leu Lys Ser Leu Asp 
    290                 295                 300                 


Phe Leu Ser Phe Thr Asp Leu Lys Asp Gly Asn Leu Glu Ala Gly Ser 
305                 310                 315                 320 


<210>  355
<211>  4308
<212>  DNA
<213>  Homosapiens

<400>  355
gctggccccg ccccctagcg ccgcggtcgg agccatttcg ccgattcctc catgcgagtt     60

gctgtgcgtt tctctgttgt ctcggtagaa ggccagagtc acacacggtc ctaagagctg    120

ggcaccagga agcgaaggct gatctgaaga agacacttga atcatgggtg acgttaaaaa    180

ttttctgtat gcctggtgtg gcaaaaggaa gatgacccca tcctatgaaa ttagagcagt    240

ggggaacaaa aacaggcaga aattcatgtg tgaggttcag gtggaaggtt ataattacac    300

tggcatggga aattccacca ataaaaaaga tgcacaaagc aatgctgcca gagactttgt    360

taactatttg gttcgaataa atgaaataaa gagtgaagaa gttccagctt ttggggtagc    420

atctccgccc ccacttactg atactcctga cactacagca aatgctgaag gagatttacc    480

aacaaccatg ggaggacctc ttcctccaca tctggctctc aaagcagaaa ataattctga    540

ggtaggggcc tctggctatg gtgttcctgg gcccacctgg gaccgaggag ccaacttgaa    600

ggattactac tcaagaaagg aagaacaaga agtgcaagcg actctagaat cagaagaagt    660

ggatttaaat gctgggcttc atggaaactg gaccttggaa aatgctaaag ctcgtctaaa    720

ccaatatttt cagaaagaaa agatccaagg agaatataag tacacccaag tgggtcctga    780

tcacaacagg agctttattg cagaaatgac catttatatc aagcagctgg gcagaaggat    840

ttttgcacga gaacatggat caaataagaa attggcagca cagtcctgtg ccctgtcact    900

tgtcagacaa ctgtaccatc ttggagtggt tgaagcttac tccggactta caaagaagaa    960

ggaaggagag acagtggagc cttacaaagt aaacctctct caagatttag agcatcagct   1020

gcaaaacatc attcaagagc taaatcttga gattttgccc ccgcctgaag atccttctgt   1080

gccagttgca ctcaacattg gcaaattggc tcagttcgaa ccatctcagc gacaaaacca   1140

agtgggtgtg gttccttggt cacctccaca atccaactgg aatccttgga ctagtagcaa   1200

cattgatgag gggcctctgg cttttgctac tccagagcaa ataagcatgg acctcaagaa   1260

tgaattgatg taccagttgg aacaggatca tgatttgcaa gcaatcttgc aggagagaga   1320

gttactgcct gtgaagaaat ttgaaagtga gattctggaa gcaatcagcc aaaattcagt   1380

tgtcattatt agaggggcta ctggatgtgg gaaaaccaca caggttcccc agttcattct   1440

agatgacttt atccagaatg accgagcagc agagtgtaac atcgtagtaa ctcagcccag   1500

aagaatcagt gcggtttctg tggcagagcg agttgcattt gaaagaggag aagagcctgg   1560

aaaaagctgt ggctacagcg ttcgatttga gtctatactt cctcgtcctc atgccagtat   1620

aatgttttgt actgtaggtg tgctcctgag aaaattagaa gcaggcattc gaggaatcag   1680

tcatgtaatt gtagatgaaa tacatgaaag agatattaat actgacttcc ttttggtagt   1740

actgcgtgat gttgttcagg cttatcctga agttcgcatt gttcttatgt ctgctactat   1800

tgataccagc atgttttgtg aatatttctt caattgcccc atcattgaag tttatgggag   1860

gacttaccca gttcaagaat attttctgga agactgcatt cagatgaccc actttgttcc   1920

tccaccaaaa gacaaaaaga agaaggataa ggatgatgat ggtggtgagg atgatgatgc   1980

aaattgcaac ttgatctgtg gtgatgaata tggtccagaa acaaggttga gcatgtctca   2040

attgaacgaa aaggaaactc cttttgaact catcgaggct ctacttaagt acattgaaac   2100

ccttaatgtt cctggagctg tgttggtttt tttgcctggc tggaatctga tttatactat   2160

gcagaagcat ttggaaatga atccacattt tggaagccat cggtatcaga ttctacccct   2220

gcattctcag attcctcgag aggaacagcg caaagtgttt gatccagtac cagttggagt   2280

aaccaaggtt attttgtcca caaatattgc tgaaacaagc attaccataa acgatgttgt   2340

ttatgtcatt gactcctgca agcagaaagt gaaactcttc actgctcaca acaatatgac   2400

caactatgct accgtatggg catcaaaaac aaaccttgag caacggaaag ggcgagctgg   2460

ccgagtacgg cctggattct gctttcacct gtgcagccga gctcgttttg agagacttga   2520

aacccacatg acaccagaga tgttccgaac accattgcat gaaattgctc ttagcataaa   2580

acttctgcgt ctaggaggaa ttggccaatt tctggccaaa gcaattgaac ctcccccttt   2640

ggatgctgtg attgaagcag aacacactct tagagagctt gatgcattag atgccaatga   2700

tgagttgact cctttgggac gaatcctggc taaactcccc attgagcctc gttttggcaa   2760

aatgatgata atggggtgta ttttctacgt gggagatgct atctgtacca ttgctgctgc   2820

tacctgcttt ccagagcctt tcatcaatga aggaaagcgg ctgggctata tccatcgaaa   2880

ttttgctgga aacagatttt ctgatcacgt agccctttta tcagtattcc aagcctggga   2940

tgatgctaga atgggtggag aagaagcaga gatacgtttt tgtgagcaca aaagacttaa   3000

tatggctaca ctaagaatga cctgggaagc caaagttcag ctcaaagaga ttttgattaa   3060

ttctgggttt ccagaagatt gtttgttgac acaagtgttt actaacactg gaccagataa   3120

taatttggat gttgttatct ccctcctggc ctttggtgtg taccccaatg tatgctatca   3180

taaggaaaag aggaagattc tcaccactga agggcgtaat gcacttatcc acaaatcatc   3240

tgttaattgt ccttttagta gccaagacat gaagtaccca tctcccttct ttgtatttgg   3300

tgaaaagatt cgaactcgag ccatctctgc taaaggcatg actttagtca cccccctgca   3360

gttgcttctc tttgcctcca agaaagtcca atctgatggg cagattgtgc ttgtagatga   3420

ctggattaaa ctgcaaatat ctcatgaagc tgctgcctgt atcactggtc tccgggcagc   3480

catggaggct ttggttgttg aagtaaccaa acaacctgct atcatcagcc agttggaccc   3540

cgtaaatgaa cgtatgctga acatgatccg tcagatctct agaccctcag ctgctggtat   3600

caaccttatg attggcagta cacggtatgg agatggtcca cgtcctccca agatggcccg   3660

atacgacaat ggaagcggat atagaagggg aggttctagt tacagtggtg gaggctatgg   3720

cggtggctat agcagtggag gctatggtag cggaggctat ggtggcagcg ccaactcctt   3780

tcgggcagga tatggtgcag gtgttggtgg aggctataga ggagtttccc gaggtggctt   3840

tagaggcaac tctggaggag actacagagg gcctagtgga ggctacagag gatctggggg   3900

attccagcga ggaggtggta ggggggccta tggaactggc tactttggac agggaagagg   3960

aggtggcggc tattaaaact tggttatgtc agttcctgtg tgtagacagt aaggaaaaaa   4020

aggcatgcta tgtgttacgt gttttttcca gtatgtttat ttgccaccaa aaagtaaatg   4080

cattttcacc cattctgtgg ttcattgtag tttaaggaaa ccaagcatat agatgcatta   4140

gtgattttgt ttatattatg taaaatataa cgatctctta aaaataccac agtttgtatt   4200

ttttctttaa ggagtaaaga tttgccttta aataacttgg tattttcctg gctttcgttt   4260

aatacaatag aaaataaagt attacaccga aaaaaaaaaa aaaaaaaa                4308


<210>  356
<211>  1270
<212>  PRT
<213>  Homosapiens

<400>  356

Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys 
1               5                   10                  15      


Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln 
            20                  25                  30          


Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met 
        35                  40                  45              


Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp 
    50                  55                  60                  


Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val 
65                  70                  75                  80  


Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp 
                85                  90                  95      


Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro 
            100                 105                 110         


Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly 
        115                 120                 125             


Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn 
    130                 135                 140                 


Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr 
145                 150                 155                 160 


Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp 
                165                 170                 175     


Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu 
            180                 185                 190         


Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn 
        195                 200                 205             


Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg 
    210                 215                 220                 


Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln 
225                 230                 235                 240 


Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val 
                245                 250                 255     


Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu 
            260                 265                 270         


Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn 
        275                 280                 285             


Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro 
    290                 295                 300                 


Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro 
305                 310                 315                 320 


Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln 
                325                 330                 335     


Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu 
            340                 345                 350         


Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu 
        355                 360                 365             


Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu 
    370                 375                 380                 


Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala 
385                 390                 395                 400 


Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly 
                405                 410                 415     


Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn 
            420                 425                 430         


Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile 
        435                 440                 445             


Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu 
    450                 455                 460                 


Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro 
465                 470                 475                 480 


Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg 
                485                 490                 495     


Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu 
            500                 505                 510         


Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg 
        515                 520                 525             


Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala 
    530                 535                 540                 


Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile 
545                 550                 555                 560 


Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu 
                565                 570                 575     


Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys 
            580                 585                 590         


Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys 
        595                 600                 605             


Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met 
    610                 615                 620                 


Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu 
625                 630                 635                 640 


Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe 
                645                 650                 655     


Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met 
            660                 665                 670         


Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser 
        675                 680                 685             


Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val 
    690                 695                 700                 


Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile 
705                 710                 715                 720 


Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val 
                725                 730                 735     


Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr Val Trp 
            740                 745                 750         


Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Val 
        755                 760                 765             


Arg Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg 
    770                 775                 780                 


Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu 
785                 790                 795                 800 


Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe 
                805                 810                 815     


Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala 
            820                 825                 830         


Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu 
        835                 840                 845             


Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe 
    850                 855                 860                 


Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile 
865                 870                 875                 880 


Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu 
                885                 890                 895     


Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe 
            900                 905                 910         


Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala 
        915                 920                 925             


Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg 
    930                 935                 940                 


Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu 
945                 950                 955                 960 


Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr 
                965                 970                 975     


Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile 
            980                 985                 990         


Ser Leu Leu Ala Phe Gly Val Tyr  Pro Asn Val Cys Tyr  His Lys Glu 
        995                 1000                 1005             


Lys Arg  Lys Ile Leu Thr Thr  Glu Gly Arg Asn Ala  Leu Ile His 
    1010                 1015                 1020             


Lys Ser  Ser Val Asn Cys Pro  Phe Ser Ser Gln Asp  Met Lys Tyr 
    1025                 1030                 1035             


Pro Ser  Pro Phe Phe Val Phe  Gly Glu Lys Ile Arg  Thr Arg Ala 
    1040                 1045                 1050             


Ile Ser  Ala Lys Gly Met Thr  Leu Val Thr Pro Leu  Gln Leu Leu 
    1055                 1060                 1065             


Leu Phe  Ala Ser Lys Lys Val  Gln Ser Asp Gly Gln  Ile Val Leu 
    1070                 1075                 1080             


Val Asp  Asp Trp Ile Lys Leu  Gln Ile Ser His Glu  Ala Ala Ala 
    1085                 1090                 1095             


Cys Ile  Thr Gly Leu Arg Ala  Ala Met Glu Ala Leu  Val Val Glu 
    1100                 1105                 1110             


Val Thr  Lys Gln Pro Ala Ile  Ile Ser Gln Leu Asp  Pro Val Asn 
    1115                 1120                 1125             


Glu Arg  Met Leu Asn Met Ile  Arg Gln Ile Ser Arg  Pro Ser Ala 
    1130                 1135                 1140             


Ala Gly  Ile Asn Leu Met Ile  Gly Ser Thr Arg Tyr  Gly Asp Gly 
    1145                 1150                 1155             


Pro Arg  Pro Pro Lys Met Ala  Arg Tyr Asp Asn Gly  Ser Gly Tyr 
    1160                 1165                 1170             


Arg Arg  Gly Gly Ser Ser Tyr  Ser Gly Gly Gly Tyr  Gly Gly Gly 
    1175                 1180                 1185             


Tyr Ser  Ser Gly Gly Tyr Gly  Ser Gly Gly Tyr Gly  Gly Ser Ala 
    1190                 1195                 1200             


Asn Ser  Phe Arg Ala Gly Tyr  Gly Ala Gly Val Gly  Gly Gly Tyr 
    1205                 1210                 1215             


Arg Gly  Val Ser Arg Gly Gly  Phe Arg Gly Asn Ser  Gly Gly Asp 
    1220                 1225                 1230             


Tyr Arg  Gly Pro Ser Gly Gly  Tyr Arg Gly Ser Gly  Gly Phe Gln 
    1235                 1240                 1245             


Arg Gly  Gly Gly Arg Gly Ala  Tyr Gly Thr Gly Tyr  Phe Gly Gln 
    1250                 1255                 1260             


Gly Arg  Gly Gly Gly Gly Tyr  
    1265                 1270 


<210>  357
<211>  2381
<212>  DNA
<213>  Homosapiens

<400>  357
ccctgtcctg agcccaggcg cttcgccctg tcccacctag ctctgagcag cgccccccag     60

caccctgaat gcgtccgcag gaccccgcgc tctacccgca ggccccgcac cccctagctc    120

tgggccgcgc ctcacatccc tcccagagcc gcaacacccc acccggcggg acgccctcga    180

gcagccgctc gttgcgggcc tgaagcgcag agcgcctatt ggccagagcg gccgagggcg    240

ggaaaagtgg ccaacggctg cctcggccct cgggctgctg aggagatggc gtcgggctcc    300

aaggcctcgg tgcccgcgga ctcattccgc accatcagcc cggacaggcg aggcgagaag    360

tccgcctccg ctgtctccgg ggacacggcg gccgcgacca ccctgaaggg caccgcgatc    420

ccagtgcggt cggtggtggc ctcccctcgc ccggtgaagg ggaaagcggg ccgggagacg    480

gccaggctgc ggctccagcg cctgcccgcg gctcaggccg aggacacggg agaggcggcg    540

gcggcggcgg cggaggagcc cctgctgcca gtgcctgagg atgaagagga ggcgcagccc    600

ctgcccccag tctgcgtgtc ccgtatgagg gggatgtggc gggacgagaa ggtgtcgctg    660

tattgcgacg aagtgctgca ggactgtaag gcagaagatg ctgatgaagt tatgggtaaa    720

tacctatcag aaaaattaaa gttgaaagac aaatggcttg gagtctggaa gactaatccc    780

agtgtattct ttgtgaaata tgaagaagct tctatccctt ttgttggtat attggttgag    840

gtaacttgtg aaccatacca agactcatca tctcgtttca aagttactgt ttctgttgct    900

gagccctttt cttccaacat tgcaaatatt ccaagagatt tggttgatga gattttggag    960

gaactggaac acagtgtgcc tcttttggaa gtgtatcctg ttgagggaca agatactgat   1020

atacatgtta ttgctttggc cttggaagtt gtcaggtttt tttatgactt tctttggaga   1080

gactgggatg atgaagaaag ttgtgagaat tatactgcac ttattgaaga aagaattaat   1140

ttgtggtgtg atatacagga tggaacaata cctggtccta tcgcacaacg ttttaaaaaa   1200

actttggaga aatataaaaa caaacgtgtc gagctcattg agtatcagag caatattaaa   1260

gaagatccat ctgcagcaga ggctgttgaa tgctggaaaa aatactatga gatagtcatg   1320

ctctgtggat tactgaaaat gtgggaagat ttacgcctcc gagttcatgg acctttcttt   1380

ccaagaattc tgaggcgtag gaaaggaaaa agagaatttg gaaagactat aacacatatt   1440

gtagcaaaaa tgatgactac tgaaatgata aaggatttat cttcagacac acttctccaa   1500

cagcatggtg atttggattt ggctttggat aattgttata gtggagatac agtaataatt   1560

tttccaggag aatatcaagc tgcaaatctt gctttgttga cagatgacat cattataaag   1620

ggagttggaa agagagagga aattatgatt acttctgaac cttctcgtga cagttttgtg   1680

gtgtccaaag ctgacaatgt gaaactaatg catctatctt tgatacaaca agggacggtt   1740

gatggtatcg tggtggtgga gtctggtcac atgactctag aaaactgcat attaaaatgt   1800

gaaggaacag gagtgtgtgt tcttacaggg gctgctttga caattacaga cagtgaaata   1860

actggcgccc agggtgctgg tgttgaactg tatcctggaa gcatagctat tttggaaaga   1920

aatgaaattc atcactgtaa taacctcaga accagtaaca gttcaaaaag caccttaggt   1980

ggagttaata tgaaggttct tccagcaccc aaattgaaga tgactaataa tcatatttat   2040

agcaacaaag gctatggagt aagcattctt caaccaatgg aacagttttt tatcgtagca   2100

gaagaagctc tcaacaaaag ggcttcttca ggagataaaa aagatgataa aatgctcttc   2160

aaagtaatgc aaaatctgaa tctggaaatg aataataata agatagaagc aaacgtcaag   2220

ggggatatca gaatagtcac aagttaaagc gtctgaattg atgttaaagt tttatatttc   2280

acaaatttgt ttaatacatg attctcatac cccactgaaa tggtagtttc aattcaaagc   2340

ttaattaaaa aatatttaaa tatcaaaaaa aaaaaaaaaa a                       2381


<210>  358
<211>  653
<212>  PRT
<213>  Homosapiens

<400>  358

Met Ala Ser Gly Ser Lys Ala Ser Val Pro Ala Asp Ser Phe Arg Thr 
1               5                   10                  15      


Ile Ser Pro Asp Arg Arg Gly Glu Lys Ser Ala Ser Ala Val Ser Gly 
            20                  25                  30          


Asp Thr Ala Ala Ala Thr Thr Leu Lys Gly Thr Ala Ile Pro Val Arg 
        35                  40                  45              


Ser Val Val Ala Ser Pro Arg Pro Val Lys Gly Lys Ala Gly Arg Glu 
    50                  55                  60                  


Thr Ala Arg Leu Arg Leu Gln Arg Leu Pro Ala Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Thr Gly Glu Ala Ala Ala Ala Ala Ala Glu Glu Pro Leu Leu Pro Val 
                85                  90                  95      


Pro Glu Asp Glu Glu Glu Ala Gln Pro Leu Pro Pro Val Cys Val Ser 
            100                 105                 110         


Arg Met Arg Gly Met Trp Arg Asp Glu Lys Val Ser Leu Tyr Cys Asp 
        115                 120                 125             


Glu Val Leu Gln Asp Cys Lys Ala Glu Asp Ala Asp Glu Val Met Gly 
    130                 135                 140                 


Lys Tyr Leu Ser Glu Lys Leu Lys Leu Lys Asp Lys Trp Leu Gly Val 
145                 150                 155                 160 


Trp Lys Thr Asn Pro Ser Val Phe Phe Val Lys Tyr Glu Glu Ala Ser 
                165                 170                 175     


Ile Pro Phe Val Gly Ile Leu Val Glu Val Thr Cys Glu Pro Tyr Gln 
            180                 185                 190         


Asp Ser Ser Ser Arg Phe Lys Val Thr Val Ser Val Ala Glu Pro Phe 
        195                 200                 205             


Ser Ser Asn Ile Ala Asn Ile Pro Arg Asp Leu Val Asp Glu Ile Leu 
    210                 215                 220                 


Glu Glu Leu Glu His Ser Val Pro Leu Leu Glu Val Tyr Pro Val Glu 
225                 230                 235                 240 


Gly Gln Asp Thr Asp Ile His Val Ile Ala Leu Ala Leu Glu Val Val 
                245                 250                 255     


Arg Phe Phe Tyr Asp Phe Leu Trp Arg Asp Trp Asp Asp Glu Glu Ser 
            260                 265                 270         


Cys Glu Asn Tyr Thr Ala Leu Ile Glu Glu Arg Ile Asn Leu Trp Cys 
        275                 280                 285             


Asp Ile Gln Asp Gly Thr Ile Pro Gly Pro Ile Ala Gln Arg Phe Lys 
    290                 295                 300                 


Lys Thr Leu Glu Lys Tyr Lys Asn Lys Arg Val Glu Leu Ile Glu Tyr 
305                 310                 315                 320 


Gln Ser Asn Ile Lys Glu Asp Pro Ser Ala Ala Glu Ala Val Glu Cys 
                325                 330                 335     


Trp Lys Lys Tyr Tyr Glu Ile Val Met Leu Cys Gly Leu Leu Lys Met 
            340                 345                 350         


Trp Glu Asp Leu Arg Leu Arg Val His Gly Pro Phe Phe Pro Arg Ile 
        355                 360                 365             


Leu Arg Arg Arg Lys Gly Lys Arg Glu Phe Gly Lys Thr Ile Thr His 
    370                 375                 380                 


Ile Val Ala Lys Met Met Thr Thr Glu Met Ile Lys Asp Leu Ser Ser 
385                 390                 395                 400 


Asp Thr Leu Leu Gln Gln His Gly Asp Leu Asp Leu Ala Leu Asp Asn 
                405                 410                 415     


Cys Tyr Ser Gly Asp Thr Val Ile Ile Phe Pro Gly Glu Tyr Gln Ala 
            420                 425                 430         


Ala Asn Leu Ala Leu Leu Thr Asp Asp Ile Ile Ile Lys Gly Val Gly 
        435                 440                 445             


Lys Arg Glu Glu Ile Met Ile Thr Ser Glu Pro Ser Arg Asp Ser Phe 
    450                 455                 460                 


Val Val Ser Lys Ala Asp Asn Val Lys Leu Met His Leu Ser Leu Ile 
465                 470                 475                 480 


Gln Gln Gly Thr Val Asp Gly Ile Val Val Val Glu Ser Gly His Met 
                485                 490                 495     


Thr Leu Glu Asn Cys Ile Leu Lys Cys Glu Gly Thr Gly Val Cys Val 
            500                 505                 510         


Leu Thr Gly Ala Ala Leu Thr Ile Thr Asp Ser Glu Ile Thr Gly Ala 
        515                 520                 525             


Gln Gly Ala Gly Val Glu Leu Tyr Pro Gly Ser Ile Ala Ile Leu Glu 
    530                 535                 540                 


Arg Asn Glu Ile His His Cys Asn Asn Leu Arg Thr Ser Asn Ser Ser 
545                 550                 555                 560 


Lys Ser Thr Leu Gly Gly Val Asn Met Lys Val Leu Pro Ala Pro Lys 
                565                 570                 575     


Leu Lys Met Thr Asn Asn His Ile Tyr Ser Asn Lys Gly Tyr Gly Val 
            580                 585                 590         


Ser Ile Leu Gln Pro Met Glu Gln Phe Phe Ile Val Ala Glu Glu Ala 
        595                 600                 605             


Leu Asn Lys Arg Ala Ser Ser Gly Asp Lys Lys Asp Asp Lys Met Leu 
    610                 615                 620                 


Phe Lys Val Met Gln Asn Leu Asn Leu Glu Met Asn Asn Asn Lys Ile 
625                 630                 635                 640 


Glu Ala Asn Val Lys Gly Asp Ile Arg Ile Val Thr Ser 
                645                 650             


<210>  359
<211>  7923
<212>  DNA
<213>  Homosapiens

<400>  359
gcgcactcgg gcacgcgctc ggaagtcggg ggtcggcgcg gagtgcaggc tgctcccggg     60

gtaggtgagg gaagcgcgga ggcggggcgc gggggcagtg gtcggcgagc agcgcggtcc    120

tcgctagggg cgcccacccg tcagtctctc cggcgcgagc cgccgccacc gcccgcgccg    180

gagtcaggcc cctgggcccc caggctcaag cagcgaagcg gcctccgggg gacgccgcta    240

ggcgagagga acgcgccggt gcccttgcct tcgccgtgac ccagcgtgcg ggcggcggga    300

tgagagggag ccatcgggcc gcgccggccc tgcggccccg ggggcggctc tggcccgtgc    360

tggccgtgct ggcggcggcc gccgcggcgg gctgtgccca ggcagccatg gacgagtgca    420

cggacgaggg cgggcggccg cagcgctgca tgcccgagtt cgtcaacgcc gctttcaacg    480

tgactgtggt ggccaccaac acgtgtggga ctccgcccga ggaatactgt gtgcagaccg    540

gggtgaccgg ggtcaccaag tcctgtcacc tgtgcgacgc cgggcagccc cacctgcagc    600

acggggcagc cttcctgacc gactacaaca accaggccga caccacctgg tggcaaagcc    660

agaccatgct ggccggggtg cagtacccca gctccatcaa cctcacgctg cacctgggaa    720

aagcttttga catcacctat gtgcgtctca agttccacac cagccgcccg gagagctttg    780

ccatttacaa gcgcacacgg gaagacgggc cctggattcc ttaccagtac tacagtggtt    840

cctgcgagaa cacctactcc aaggcaaacc gcggcttcat caggacagga ggggacgagc    900

agcaggcctt gtgtactgat gaattcagtg acatttctcc cctcactggg ggcaacgtgg    960

ccttttctac cctggaagga aggcccagcg cctataactt tgacaatagc cctgtgctgc   1020

aggaatgggt aactgccact gacatcagag taactcttaa tcgcctgaac acttttggag   1080

atgaagtgtt taacgatccc aaagttctca agtcctatta ttatgccatc tctgattttg   1140

ctgtaggtgg cagatgtaaa tgtaatggac acgcaagcga gtgtatgaag aacgaatttg   1200

ataagctggt gtgtaattgc aaacataaca catatggagt agactgtgaa aagtgtcttc   1260

ctttcttcaa tgaccggccg tggaggaggg caactgcgga aagtgccagt gaatgcctgc   1320

cctgtgattg caatggtcga tcccaggaat gctacttcga ccctgaactc tatcgttcca   1380

ctggccatgg gggccactgt accaactgcc aggataacac agatggcgcc cactgtgaga   1440

ggtgccgaga gaacttcttc cgccttggca acaatgaagc ctgctcttca tgccactgta   1500

gtcctgtggg ctctctaagc acacagtgtg atagttacgg cagatgcagc tgtaagccag   1560

gagtgatggg ggacaaatgt gaccgttgcc agcctggatt ccattctctc actgaagcag   1620

gatgcaggcc atgctcttgt gatccctctg gcagcataga tgaatgtaat gttgaaacag   1680

gaagatgtgt ttgcaaagac aatgtcgaag gcttcaattg tgaaagatgc aaacctggat   1740

tttttaatct ggaatcatct aatcctcggg gttgcacacc ctgcttctgc tttgggcatt   1800

cttctgtctg tacaaacgct gttggctaca gtgtttattc tatctcctct acctttcaga   1860

ttgatgagga tgggtggcgt gcggaacaga gagatggctc tgaagcatct ctcgagtggt   1920

cctctgagag gcaagatatc gccgtgatct cagacagcta ctttcctcgg tacttcattg   1980

ctcctgcaaa gttcttgggc aagcaggtgt tgagttatgg tcagaacctc tccttctcct   2040

ttcgagtgga caggcgagat actcgcctct ctgccgaaga ccttgtgctt gagggagctg   2100

gcttaagagt atctgtaccc ttgatcgctc agggcaattc ctatccaagt gagaccactg   2160

tgaagtatgt cttcaggctc catgaagcaa cagattaccc ttggaggcct gctcttaccc   2220

cttttgaatt tcagaagctc ctaaacaact tgacctctat caagatacgt gggacataca   2280

gtgagagaag tgctggatat ttggatgatg tcaccctggc aagtgctcgt cctgggcctg   2340

gagtccctgc aacttgggtg gagtcctgca cctgtcctgt gggatatgga gggcagtttt   2400

gtgagatgtg cctctcaggt tacagaagag aaactcctaa tcttggacca tacagtccat   2460

gtgtgctttg cgcctgcaat ggacacagcg agacctgtga tcctgagaca ggtgtttgta   2520

actgcagaga caatacggct ggcccgcact gtgagaagtg cagtgatggg tactatggag   2580

attcaactgc aggcacctcc tccgattgcc aaccctgtcc gtgtcctgga ggttcaagtt   2640

gtgctgttgt tcccaagaca aaggaggtgg tgtgcaccaa ctgtcctact ggcaccactg   2700

gtaagagatg tgagctctgt gatgatggct actttggaga ccccctgggt agaaacggcc   2760

ctgtgagact ttgccgcctg tgccagtgca gtgacaacat cgatcccaac gcagttggaa   2820

attgcaatcg cttgacggga gaatgcctga agtgcatcta taacactgct ggcttctatt   2880

gtgaccggtg caaagacgga ttttttggaa atcccctggc tcccaatcca gcagacaaat   2940

gcaaagcctg caattgcaat ccgtatggga ccatgaagca gcagagcagc tgtaaccccg   3000

tgacggggca gtgtgaatgt ttgcctcacg tgactggcca ggactgtggt gcttgtgacc   3060

ctggattcta caatctgcag agtgggcaag gctgtgagag gtgtgactgc catgccttgg   3120

gctccaccaa tgggcagtgt gacatccgca ccggccagtg tgagtgccag cccggcatca   3180

ctggtcagca ctgtgagcgc tgtgaggtca accactttgg gtttggacct gaaggctgca   3240

aaccctgtga ctgtcatcct gagggatctc tttcacttca gtgcaaagat gatggtcgct   3300

gtgaatgcag agaaggcttt gtgggaaatc gctgtgacca gtgtgaagaa aactatttct   3360

acaatcggtc ttggcctggc tgccaggaat gtccagcttg ttaccggctg gtaaaggata   3420

aggttgctga tcatagagtg aagctccagg aattagagag tctcatagca aaccttggaa   3480

ctggggatga gatggtgaca gatcaagcct tcgaggatag actaaaggaa gcagagaggg   3540

aagttatgga cctccttcgt gaggcccagg atgtcaaaga tgttgaccag aatttgatgg   3600

atcgcctaca gagagtgaat aacactctgt ccagccaaat tagccgttta cagaatatcc   3660

ggaataccat tgaagagact ggaaacttgg ctgaacaagc gcgtgcccat gtagagaaca   3720

cagagcggtt gattgaaatc gcatccagag aacttgagaa agcaaaagtc gctgctgcca   3780

atgtgtcagt cactcagcca gaatctacag gggacccaaa caacatgact cttttggcag   3840

aagaggctcg aaagcttgct gaacgtcata aacaggaagc tgatgacatt gttcgagtgg   3900

caaagacagc caatgatacg tcaactgagg catacaacct gcttctgagg acactggcag   3960

gagaaaatca aacagcattt gagattgaag agcttaatag gaagtatgaa caagcgaaga   4020

acatctcaca ggatctggaa aaacaagctg cccgagtaca tgaggaggcc aaaagggccg   4080

gtgacaaagc tgtggagatc tatgccagcg tggctcagct gagccctttg gactctgaga   4140

cactggagaa tgaagcaaat aacataaaga tggaagctga gaatctggaa caactgattg   4200

accagaaatt aaaagattat gaggacctca gagaagatat gagagggaag gaacttgaag   4260

tcaagaacct tctggagaaa ggcaagactg aacagcagac cgcagaccaa ctcctagccc   4320

gagctgatgc tgccaaggcc ctcgctgaag aagctgcaaa gaagggacgg gataccttac   4380

aagaagctaa tgacattctc aacaacctga aagattttga taggcgcgtg aacgataaca   4440

agacggccgc agaggaggca ctaaggaaga ttcctgccat caaccagacc atcactgaag   4500

ccaatgaaaa gaccagagaa gcccagcagg ccctgggcag tgctgcggcg gatgccacag   4560

aggccaagaa caaggcccat gaggcggaga ggatcgcaag cgctgtccaa aagaatgcca   4620

ccagcaccaa ggcagaagct gaaagaactt ttgcagaagt tacagatctg gataatgagg   4680

tgaacaatat gttgaagcaa ctgcaggaag cagaaaaaga gctaaagaga aaacaagatg   4740

acgctgacca ggacatgatg atggcaggga tggcttcaca ggctgctcaa gaagccgaga   4800

tcaatgccag aaaagccaaa aactctgtta ctagcctcct cagcattatt aatgacctct   4860

tggagcagct ggggcagctg gatacagtgg acctgaataa gctaaacgag attgaaggca   4920

ccctaaacaa agccaaagat gaaatgaagg tcagcgatct tgataggaaa gtgtctgacc   4980

tggagaatga agccaagaag caggaggctg ccatcatgga ctataaccga gatatcgagg   5040

agatcatgaa ggacattcgc aatctggagg acatcaggaa gaccttacca tctggctgct   5100

tcaacacccc gtccattgaa aagccctagt gtctttaggg ctggaaggca gcatccctct   5160

gacagggggg cagttgtgag gccacagagt gccttgacac aaagattaca tttttcagac   5220

ccccactcct ctgctgctgt ccatcactgt ccttttgaac caggaaaagt cacagagttt   5280

aaagagaagc aaattaaaca tcctgaatcg ggaacaaagg gttttatcta ataaagtgtc   5340

tcttccatca cgttgctacc ttacccacac ttccctctga tttgcgtgag gacgtggcat   5400

cctacttacg tacgtggcat aacacatcgt gtgagcccat gtatgctggg gtagagcaag   5460

tagccctccc ctgtctcatc gatccagcag aacctcctca gtctcagtac tcttgtttct   5520

ataaggaaaa gttttgctac taacagtagc attgtgatgg ccagtatatc cagtccatgg   5580

ataaagaaaa tgcatctgca tctcctgccc ctcttccttc taagcaaaag gaaataaaca   5640

tcctgtgcca aaggtattgg tcatttagaa tgtcggtagc catccatcag tgcttttagc   5700

tattatgagt gtaggacact gagccatccg tgggtcagga tgcaattatt tataaaagtc   5760

cccaggtgaa catggctgaa gatttttcta gtatattaat aattgactag gaagatgaac   5820

tttttttcag atctttgggc agctgataat ttaaatctgg atgggcagct tgcactcacc   5880

aatagaccaa aagacatctt ttgatattct tataaatgga acttacacag aagaaatagg   5940

gatatgataa ccactaaagt tttgttttca aaatcaaact aattcttaca gcttttttat   6000

tagttagtct tggaactagt gttaagtatc tggcagagaa cagttaatcc ctaaggtctt   6060

gacaaaacag aagaaaaaca agcctcctcg tcctagtctt ttctagcaaa gggataaaac   6120

ttagatggca gcttgtactg tcagaatccc gtgtatccat ttgttcttct gttggagaga   6180

tgagacattt gacccttagc tccagttttc ttctgatgtt tccatcttcc agaatccctc   6240

aaaaaacatt gtttgccaaa tcctggtggc aaatacttgc actcagtatt tcacacagct   6300

gccaacgcta tcgagttcct gcactttgtg atttaaatcc actctaaacc ttccctctaa   6360

gtgtagaggg aagaccctta cgtggagttt cctagtgggc ttctcaactt ttgatcctca   6420

gctctgtggt tttaagacca cagtgtgaca gttccctgcc acacaccccc ttcctcctac   6480

caacccacct ttgagattca tatatagcct ttaacactat gcaactttgt actttgcgta   6540

gcaggggctg gggtgggggg aaagaaacct attatcatgg acacactggt gctattaatt   6600

atttcaaatt tatatttttg tgtgaatgtt ttgtgttttg tttatccatg ctatagaaca   6660

aggaatttat gtagatatac ttagtcctat ttctagaatg acactctgtt cactttgctc   6720

aatttttcct cttcactggc acaagtatct gaatacctcc ttccctccct tctagagttc   6780

tttggattgt actccaaaga attgtgcctt gtgtttgcag catctccatt ctctaaatta   6840

atataattgc tttcctccac acccagccac gtaaagaggt aacttgggtc ctcttccatt   6900

gcagtcctga tgatcctaac ctgcagcacg gtggttttac aatgttccag agcaggaacg   6960

ccaggttgac aagctatggt aggattagga aagtttgctg aagaggatct ttgacgccac   7020

agtgggacta gccaggaatg agggagaaat gccctttttg gcaattgttg gagctggata   7080

ggtaagtttt ataagggagt acattttgac tgagcactta gggcatcagg aacagtgcta   7140

cttactggtg ggtagactgg gagaggtggt gtaacttagt tcttgatgat cccacttcct   7200

gtttccatct gcttgggata taccagagtt taccacaagt gttttgacga tatactcctg   7260

agctttcact ctgctggctt ctcccaggcc tcttctacta tggcaggaga tgtggtgtgc   7320

tgttgcaaag ttttcacgtc atcgtttcct ggctagttca tttcattaag tggctacatc   7380

ctaacatatg cattggtcaa ggttgcagca agaggactga agattgactg ccaagctagt   7440

ttgggtgaag ttcactccag caagtctcag gccacaatgg ggtggtttgg tttggtttcc   7500

ttttaacttt ctttttgtta tttgcttttc tcctccacct gtgtggtata ttttttaagc   7560

agaattttat tttttaaaat aaaaggttct ttacaagatg ataccttaat tacactcccg   7620

caacacagcc attattttat tgtctagctc cagttatctg tattttatgt aatgtaattg   7680

acaggatggc tgctgcagaa tgctggttga cacagggatt attatactgc tatttttccc   7740

tgaattcttt tccttggaat tccaactgtg gaccttttat atgtgccttc actttagctg   7800

tttgccttac tctacagcct tgctctccgg ggtggttaat aaaatgcaac acttggcatt   7860

tttatgttat aagaaaaaca gtattttatt tataataaaa tctgaatatt ttgtaaccct   7920

tta                                                                 7923


<210>  360
<211>  1609
<212>  PRT
<213>  Homosapiens

<400>  360

Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln 
        35                  40                  45              


Arg Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val 
    50                  55                  60                  


Ala Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr 
65                  70                  75                  80  


Gly Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln 
                85                  90                  95      


Pro His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln 
            100                 105                 110         


Ala Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln 
        115                 120                 125             


Tyr Pro Ser Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp 
    130                 135                 140                 


Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe 
145                 150                 155                 160 


Ala Ile Tyr Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly 
            180                 185                 190         


Phe Ile Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu 
        195                 200                 205             


Phe Ser Asp Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr 
    210                 215                 220                 


Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu 
225                 230                 235                 240 


Gln Glu Trp Val Thr Ala Thr Asp Ile Arg Val Thr Leu Asn Arg Leu 
                245                 250                 255     


Asn Thr Phe Gly Asp Glu Val Phe Asn Asp Pro Lys Val Leu Lys Ser 
            260                 265                 270         


Tyr Tyr Tyr Ala Ile Ser Asp Phe Ala Val Gly Gly Arg Cys Lys Cys 
        275                 280                 285             


Asn Gly His Ala Ser Glu Cys Met Lys Asn Glu Phe Asp Lys Leu Val 
    290                 295                 300                 


Cys Asn Cys Lys His Asn Thr Tyr Gly Val Asp Cys Glu Lys Cys Leu 
305                 310                 315                 320 


Pro Phe Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr Ala Glu Ser Ala 
                325                 330                 335     


Ser Glu Cys Leu Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr 
            340                 345                 350         


Phe Asp Pro Glu Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr 
        355                 360                 365             


Asn Cys Gln Asp Asn Thr Asp Gly Ala His Cys Glu Arg Cys Arg Glu 
    370                 375                 380                 


Asn Phe Phe Arg Leu Gly Asn Asn Glu Ala Cys Ser Ser Cys His Cys 
385                 390                 395                 400 


Ser Pro Val Gly Ser Leu Ser Thr Gln Cys Asp Ser Tyr Gly Arg Cys 
                405                 410                 415     


Ser Cys Lys Pro Gly Val Met Gly Asp Lys Cys Asp Arg Cys Gln Pro 
            420                 425                 430         


Gly Phe His Ser Leu Thr Glu Ala Gly Cys Arg Pro Cys Ser Cys Asp 
        435                 440                 445             


Pro Ser Gly Ser Ile Asp Glu Cys Asn Val Glu Thr Gly Arg Cys Val 
    450                 455                 460                 


Cys Lys Asp Asn Val Glu Gly Phe Asn Cys Glu Arg Cys Lys Pro Gly 
465                 470                 475                 480 


Phe Phe Asn Leu Glu Ser Ser Asn Pro Arg Gly Cys Thr Pro Cys Phe 
                485                 490                 495     


Cys Phe Gly His Ser Ser Val Cys Thr Asn Ala Val Gly Tyr Ser Val 
            500                 505                 510         


Tyr Ser Ile Ser Ser Thr Phe Gln Ile Asp Glu Asp Gly Trp Arg Ala 
        515                 520                 525             


Glu Gln Arg Asp Gly Ser Glu Ala Ser Leu Glu Trp Ser Ser Glu Arg 
    530                 535                 540                 


Gln Asp Ile Ala Val Ile Ser Asp Ser Tyr Phe Pro Arg Tyr Phe Ile 
545                 550                 555                 560 


Ala Pro Ala Lys Phe Leu Gly Lys Gln Val Leu Ser Tyr Gly Gln Asn 
                565                 570                 575     


Leu Ser Phe Ser Phe Arg Val Asp Arg Arg Asp Thr Arg Leu Ser Ala 
            580                 585                 590         


Glu Asp Leu Val Leu Glu Gly Ala Gly Leu Arg Val Ser Val Pro Leu 
        595                 600                 605             


Ile Ala Gln Gly Asn Ser Tyr Pro Ser Glu Thr Thr Val Lys Tyr Val 
    610                 615                 620                 


Phe Arg Leu His Glu Ala Thr Asp Tyr Pro Trp Arg Pro Ala Leu Thr 
625                 630                 635                 640 


Pro Phe Glu Phe Gln Lys Leu Leu Asn Asn Leu Thr Ser Ile Lys Ile 
                645                 650                 655     


Arg Gly Thr Tyr Ser Glu Arg Ser Ala Gly Tyr Leu Asp Asp Val Thr 
            660                 665                 670         


Leu Ala Ser Ala Arg Pro Gly Pro Gly Val Pro Ala Thr Trp Val Glu 
        675                 680                 685             


Ser Cys Thr Cys Pro Val Gly Tyr Gly Gly Gln Phe Cys Glu Met Cys 
    690                 695                 700                 


Leu Ser Gly Tyr Arg Arg Glu Thr Pro Asn Leu Gly Pro Tyr Ser Pro 
705                 710                 715                 720 


Cys Val Leu Cys Ala Cys Asn Gly His Ser Glu Thr Cys Asp Pro Glu 
                725                 730                 735     


Thr Gly Val Cys Asn Cys Arg Asp Asn Thr Ala Gly Pro His Cys Glu 
            740                 745                 750         


Lys Cys Ser Asp Gly Tyr Tyr Gly Asp Ser Thr Ala Gly Thr Ser Ser 
        755                 760                 765             


Asp Cys Gln Pro Cys Pro Cys Pro Gly Gly Ser Ser Cys Ala Val Val 
    770                 775                 780                 


Pro Lys Thr Lys Glu Val Val Cys Thr Asn Cys Pro Thr Gly Thr Thr 
785                 790                 795                 800 


Gly Lys Arg Cys Glu Leu Cys Asp Asp Gly Tyr Phe Gly Asp Pro Leu 
                805                 810                 815     


Gly Arg Asn Gly Pro Val Arg Leu Cys Arg Leu Cys Gln Cys Ser Asp 
            820                 825                 830         


Asn Ile Asp Pro Asn Ala Val Gly Asn Cys Asn Arg Leu Thr Gly Glu 
        835                 840                 845             


Cys Leu Lys Cys Ile Tyr Asn Thr Ala Gly Phe Tyr Cys Asp Arg Cys 
    850                 855                 860                 


Lys Asp Gly Phe Phe Gly Asn Pro Leu Ala Pro Asn Pro Ala Asp Lys 
865                 870                 875                 880 


Cys Lys Ala Cys Asn Cys Asn Pro Tyr Gly Thr Met Lys Gln Gln Ser 
                885                 890                 895     


Ser Cys Asn Pro Val Thr Gly Gln Cys Glu Cys Leu Pro His Val Thr 
            900                 905                 910         


Gly Gln Asp Cys Gly Ala Cys Asp Pro Gly Phe Tyr Asn Leu Gln Ser 
        915                 920                 925             


Gly Gln Gly Cys Glu Arg Cys Asp Cys His Ala Leu Gly Ser Thr Asn 
    930                 935                 940                 


Gly Gln Cys Asp Ile Arg Thr Gly Gln Cys Glu Cys Gln Pro Gly Ile 
945                 950                 955                 960 


Thr Gly Gln His Cys Glu Arg Cys Glu Val Asn His Phe Gly Phe Gly 
                965                 970                 975     


Pro Glu Gly Cys Lys Pro Cys Asp Cys His Pro Glu Gly Ser Leu Ser 
            980                 985                 990         


Leu Gln Cys Lys Asp Asp Gly Arg  Cys Glu Cys Arg Glu  Gly Phe Val 
        995                 1000                 1005             


Gly Asn  Arg Cys Asp Gln Cys  Glu Glu Asn Tyr Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Ser Trp  Pro Gly Cys Gln Glu  Cys Pro Ala Cys Tyr  Arg Leu Val 
    1025                 1030                 1035             


Lys Asp  Lys Val Ala Asp His  Arg Val Lys Leu Gln  Glu Leu Glu 
    1040                 1045                 1050             


Ser Leu  Ile Ala Asn Leu Gly  Thr Gly Asp Glu Met  Val Thr Asp 
    1055                 1060                 1065             


Gln Ala  Phe Glu Asp Arg Leu  Lys Glu Ala Glu Arg  Glu Val Met 
    1070                 1075                 1080             


Asp Leu  Leu Arg Glu Ala Gln  Asp Val Lys Asp Val  Asp Gln Asn 
    1085                 1090                 1095             


Leu Met  Asp Arg Leu Gln Arg  Val Asn Asn Thr Leu  Ser Ser Gln 
    1100                 1105                 1110             


Ile Ser  Arg Leu Gln Asn Ile  Arg Asn Thr Ile Glu  Glu Thr Gly 
    1115                 1120                 1125             


Asn Leu  Ala Glu Gln Ala Arg  Ala His Val Glu Asn  Thr Glu Arg 
    1130                 1135                 1140             


Leu Ile  Glu Ile Ala Ser Arg  Glu Leu Glu Lys Ala  Lys Val Ala 
    1145                 1150                 1155             


Ala Ala  Asn Val Ser Val Thr  Gln Pro Glu Ser Thr  Gly Asp Pro 
    1160                 1165                 1170             


Asn Asn  Met Thr Leu Leu Ala  Glu Glu Ala Arg Lys  Leu Ala Glu 
    1175                 1180                 1185             


Arg His  Lys Gln Glu Ala Asp  Asp Ile Val Arg Val  Ala Lys Thr 
    1190                 1195                 1200             


Ala Asn  Asp Thr Ser Thr Glu  Ala Tyr Asn Leu Leu  Leu Arg Thr 
    1205                 1210                 1215             


Leu Ala  Gly Glu Asn Gln Thr  Ala Phe Glu Ile Glu  Glu Leu Asn 
    1220                 1225                 1230             


Arg Lys  Tyr Glu Gln Ala Lys  Asn Ile Ser Gln Asp  Leu Glu Lys 
    1235                 1240                 1245             


Gln Ala  Ala Arg Val His Glu  Glu Ala Lys Arg Ala  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Glu Ile Tyr Ala Ser  Val Ala Gln Leu Ser  Pro Leu Asp 
    1265                 1270                 1275             


Ser Glu  Thr Leu Glu Asn Glu  Ala Asn Asn Ile Lys  Met Glu Ala 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gln Leu Ile  Asp Gln Lys Leu Lys  Asp Tyr Glu 
    1295                 1300                 1305             


Asp Leu  Arg Glu Asp Met Arg  Gly Lys Glu Leu Glu  Val Lys Asn 
    1310                 1315                 1320             


Leu Leu  Glu Lys Gly Lys Thr  Glu Gln Gln Thr Ala  Asp Gln Leu 
    1325                 1330                 1335             


Leu Ala  Arg Ala Asp Ala Ala  Lys Ala Leu Ala Glu  Glu Ala Ala 
    1340                 1345                 1350             


Lys Lys  Gly Arg Asp Thr Leu  Gln Glu Ala Asn Asp  Ile Leu Asn 
    1355                 1360                 1365             


Asn Leu  Lys Asp Phe Asp Arg  Arg Val Asn Asp Asn  Lys Thr Ala 
    1370                 1375                 1380             


Ala Glu  Glu Ala Leu Arg Lys  Ile Pro Ala Ile Asn  Gln Thr Ile 
    1385                 1390                 1395             


Thr Glu  Ala Asn Glu Lys Thr  Arg Glu Ala Gln Gln  Ala Leu Gly 
    1400                 1405                 1410             


Ser Ala  Ala Ala Asp Ala Thr  Glu Ala Lys Asn Lys  Ala His Glu 
    1415                 1420                 1425             


Ala Glu  Arg Ile Ala Ser Ala  Val Gln Lys Asn Ala  Thr Ser Thr 
    1430                 1435                 1440             


Lys Ala  Glu Ala Glu Arg Thr  Phe Ala Glu Val Thr  Asp Leu Asp 
    1445                 1450                 1455             


Asn Glu  Val Asn Asn Met Leu  Lys Gln Leu Gln Glu  Ala Glu Lys 
    1460                 1465                 1470             


Glu Leu  Lys Arg Lys Gln Asp  Asp Ala Asp Gln Asp  Met Met Met 
    1475                 1480                 1485             


Ala Gly  Met Ala Ser Gln Ala  Ala Gln Glu Ala Glu  Ile Asn Ala 
    1490                 1495                 1500             


Arg Lys  Ala Lys Asn Ser Val  Thr Ser Leu Leu Ser  Ile Ile Asn 
    1505                 1510                 1515             


Asp Leu  Leu Glu Gln Leu Gly  Gln Leu Asp Thr Val  Asp Leu Asn 
    1520                 1525                 1530             


Lys Leu  Asn Glu Ile Glu Gly  Thr Leu Asn Lys Ala  Lys Asp Glu 
    1535                 1540                 1545             


Met Lys  Val Ser Asp Leu Asp  Arg Lys Val Ser Asp  Leu Glu Asn 
    1550                 1555                 1560             


Glu Ala  Lys Lys Gln Glu Ala  Ala Ile Met Asp Tyr  Asn Arg Asp 
    1565                 1570                 1575             


Ile Glu  Glu Ile Met Lys Asp  Ile Arg Asn Leu Glu  Asp Ile Arg 
    1580                 1585                 1590             


Lys Thr  Leu Pro Ser Gly Cys  Phe Asn Thr Pro Ser  Ile Glu Lys 
    1595                 1600                 1605             


Pro 
    


<210>  361
<211>  5175
<212>  DNA
<213>  Homosapiens

<400>  361
acagcggagc gcagagtgag aaccaccaac cgaggcgccg ggcagcgacc cctgcagcgg     60

agacagagac tgagcggccc ggcaccgcca tgcctgcgct ctggctgggc tgctgcctct    120

gcttctcgct cctcctgccc gcagcccggg ccacctccag gagggaagtc tgtgattgca    180

atgggaagtc caggcagtgt atctttgatc gggaacttca cagacaaact ggtaatggat    240

tccgctgcct caactgcaat gacaacactg atggcattca ctgcgagaag tgcaagaatg    300

gcttttaccg gcacagagaa agggaccgct gtttgccctg caattgtaac tccaaaggtt    360

ctcttagtgc tcgatgtgac aactctggac ggtgcagctg taaaccaggt gtgacaggag    420

ccagatgcga ccgatgtctg ccaggcttcc acatgctcac ggatgcgggg tgcacccaag    480

accagagact gctagactcc aagtgtgact gtgacccagc tggcatcgca gggccctgtg    540

acgcgggccg ctgtgtctgc aagccagctg ttactggaga acgctgtgat aggtgtcgat    600

caggttacta taatctggat ggggggaacc ctgagggctg tacccagtgt ttctgctatg    660

ggcattcagc cagctgccgc agctctgcag aatacagtgt ccataagatc acctctacct    720

ttcatcaaga tgttgatggc tggaaggctg tccaacgaaa tgggtctcct gcaaagctcc    780

aatggtcaca gcgccatcaa gatgtgttta gctcagccca acgactagac cctgtctatt    840

ttgtggctcc tgccaaattt cttgggaatc aacaggtgag ctatgggcaa agcctgtcct    900

ttgactaccg tgtggacaga ggaggcagac acccatctgc ccatgatgtg attctggaag    960

gtgctggtct acggatcaca gctcccttga tgccacttgg caagacactg ccttgtgggc   1020

tcaccaagac ttacacattc aggttaaatg agcatccaag caataattgg agcccccagc   1080

tgagttactt tgagtatcga aggttactgc ggaatctcac agccctccgc atccgagcta   1140

catatggaga atacagtact gggtacattg acaatgtgac cctgatttca gcccgccctg   1200

tctctggagc cccagcaccc tgggttgaac agtgtatatg tcctgttggg tacaaggggc   1260

aattctgcca ggattgtgct tctggctaca agagagattc agcgagactg gggccttttg   1320

gcacctgtat tccttgtaac tgtcaagggg gaggggcctg tgatccagac acaggagatt   1380

gttattcagg ggatgagaat cctgacattg agtgtgctga ctgcccaatt ggtttctaca   1440

acgatccgca cgacccccgc agctgcaagc catgtccctg tcataacggg ttcagctgct   1500

cagtgatgcc ggagacggag gaggtggtgt gcaataactg ccctcccggg gtcaccggtg   1560

cccgctgtga gctctgtgct gatggctact ttggggaccc ctttggtgaa catggcccag   1620

tgaggccttg tcagccctgt caatgcaaca acaatgtgga ccccagtgcc tctgggaatt   1680

gtgaccggct gacaggcagg tgtttgaagt gtatccacaa cacagccggc atctactgcg   1740

accagtgcaa agcaggctac ttcggggacc cattggctcc caacccagca gacaagtgtc   1800

gagcttgcaa ctgtaacccc atgggctcag agcctgtagg atgtcgaagt gatggcacct   1860

gtgtttgcaa gccaggattt ggtggcccca actgtgagca tggagcattc agctgtccag   1920

cttgctataa tcaagtgaag attcagatgg atcagtttat gcagcagctt cagagaatgg   1980

aggccctgat ttcaaaggct cagggtggtg atggagtagt acctgataca gagctggaag   2040

gcaggatgca gcaggctgag caggcccttc aggacattct gagagatgcc cagatttcag   2100

aaggtgctag cagatccctt ggtctccagt tggccaaggt gaggagccaa gagaacagct   2160

accagagccg cctggatgac ctcaagatga ctgtggaaag agttcgggct ctgggaagtc   2220

agtaccagaa ccgagttcgg gatactcaca ggctcatcac tcagatgcag ctgagcctgg   2280

cagaaagtga agcttccttg ggaaacacta acattcctgc ctcagaccac tacgtggggc   2340

caaatggctt taaaagtctg gctcaggagg ccacaagatt agcagaaagc cacgttgagt   2400

cagccagtaa catggagcaa ctgacaaggg aaactgagga ctattccaaa caagccctct   2460

cactggtgcg caaggccctg catgaaggag tcggaagcgg aagcggtagc ccggacggtg   2520

ctgtggtgca agggcttgtg gaaaaattgg agaaaaccaa gtccctggcc cagcagttga   2580

caagggaggc cactcaagcg gaaattgaag cagataggtc ttatcagcac agtctccgcc   2640

tcctggattc agtgtctcgg cttcagggag tcagtgatca gtcctttcag gtggaagaag   2700

caaagaggat caaacaaaaa gcggattcac tctcaacgct ggtaaccagg catatggatg   2760

agttcaagcg tacacaaaag aatctgggaa actggaaaga agaagcacag cagctcttac   2820

agaatggaaa aagtgggaga gagaaatcag atcagctgct ttcccgtgcc aatcttgcta   2880

aaagcagagc acaagaagca ctgagtatgg gcaatgccac tttttatgaa gttgagagca   2940

tccttaaaaa cctcagagag tttgacctgc aggtggacaa cagaaaagca gaagctgaag   3000

aagccatgaa gagactctcc tacatcagcc agaaggtttc agatgccagt gacaagaccc   3060

agcaagcaga aagagccctg gggagcgctg ctgctgatgc acagagggca aagaatgggg   3120

ccggggaggc cctggaaatc tccagtgaga ttgaacagga gattgggagt ctgaacttgg   3180

aagccaatgt gacagcagat ggagccttgg ccatggaaaa gggactggcc tctctgaaga   3240

gtgagatgag ggaagtggaa ggagagctgg aaaggaagga gctggagttt gacacgaata   3300

tggatgcagt acagatggtg attacagaag cccagaaggt tgataccaga gccaagaacg   3360

ctggggttac aatccaagac acactcaaca cattagacgg cctcctgcat ctgatggacc   3420

agcctctcag tgtagatgaa gaggggctgg tcttactgga gcagaagctt tcccgagcca   3480

agacccagat caacagccaa ctgcggccca tgatgtcaga gctggaagag agggcacgtc   3540

agcagagggg ccacctccat ttgctggaga caagcataga tgggattctg gctgatgtga   3600

agaacttgga gaacattagg gacaacctgc ccccaggctg ctacaatacc caggctcttg   3660

agcaacagtg aagctgccat aaatatttct caactgaggt tcttgggata cagatctcag   3720

ggctcgggag ccatgtcatg tgagtgggtg ggatggggac atttgaacat gtttaatggg   3780

tatgctcagg tcaactgacc tgaccccatt cctgatccca tggccaggtg gttgtcttat   3840

tgcaccatac tccttgcttc ctgatgctgg gcaatgaggc agatagcact gggtgtgaga   3900

atgatcaagg atctggaccc caaagaatag actggatgga aagacaaact gcacaggcag   3960

atgtttgcct cataatagtc gtaagtggag tcctggaatt tggacaagtg ctgttgggat   4020

atagtcaact tattctttga gtaatgtgac taaaggaaaa aactttgact ttgcccaggc   4080

atgaaattct tcctaatgtc agaacagagt gcaacccagt cacactgtgg ccagtaaaat   4140

actattgcct catattgtcc tctgcaagct tcttgctgat cagagttcct cctacttaca   4200

acccagggtg tgaacatgtt ctccattttc aagctggaag aagtgagcag tgttggagtg   4260

aggacctgta aggcaggccc attcagagct atggtgcttg ctggtgcctg ccaccttcaa   4320

gttctggacc tgggcatgac atcctttctt ttaatgatgc catggcaact tagagattgc   4380

atttttatta aagcatttcc taccagcaaa gcaaatgttg ggaaagtatt tactttttcg   4440

gtttcaaagt gatagaaaag tgtggcttgg gcattgaaag aggtaaaatt ctctagattt   4500

attagtccta attcaatcct acttttcgaa caccaaaaat gatgcgcatc aatgtatttt   4560

atcttatttt ctcaatctcc tctctctttc ctccacccat aataagagaa tgttcctact   4620

cacacttcag ctgggtcaca tccatccctc cattcatcct tccatccatc tttccatcca   4680

ttacctccat ccatccttcc aacatatatt tattgagtac ctactgtgtg ccaggggctg   4740

gtgggacagt ggtgacatag tctctgccct catagagttg attgtctagt gaggaagaca   4800

agcattttta aaaaataaat ttaaacttac aaactttgtt tgtcacaagt ggtgtttatt   4860

gcaataaccg cttggtttgc aacctctttg ctcaacagaa catatgttgc aagaccctcc   4920

catgggggca cttgagtttt ggcaaggctg acagagctct gggttgtgca catttctttg   4980

cattccagct gtcactctgt gcctttctac aactgattgc aacagactgt tgagttatga   5040

taacaccagt gggaattgct ggaggaacca gaggcacttc caccttggct gggaagacta   5100

tggtgctgcc ttgcttctgt atttccttgg attttcctga aagtgttttt aaataaagaa   5160

caattgttag atgcc                                                    5175


<210>  362
<211>  1193
<212>  PRT
<213>  Homosapiens

<400>  362

Met Pro Ala Leu Trp Leu Gly Cys Cys Leu Cys Phe Ser Leu Leu Leu 
1               5                   10                  15      


Pro Ala Ala Arg Ala Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly 
            20                  25                  30          


Lys Ser Arg Gln Cys Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly 
        35                  40                  45              


Asn Gly Phe Arg Cys Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His 
    50                  55                  60                  


Cys Glu Lys Cys Lys Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg 
65                  70                  75                  80  


Cys Leu Pro Cys Asn Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys 
                85                  90                  95      


Asp Asn Ser Gly Arg Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg 
            100                 105                 110         


Cys Asp Arg Cys Leu Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys 
        115                 120                 125             


Thr Gln Asp Gln Arg Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala 
    130                 135                 140                 


Gly Ile Ala Gly Pro Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala 
145                 150                 155                 160 


Val Thr Gly Glu Arg Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu 
                165                 170                 175     


Asp Gly Gly Asn Pro Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His 
            180                 185                 190         


Ser Ala Ser Cys Arg Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr 
        195                 200                 205             


Ser Thr Phe His Gln Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn 
    210                 215                 220                 


Gly Ser Pro Ala Lys Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe 
225                 230                 235                 240 


Ser Ser Ala Gln Arg Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys 
                245                 250                 255     


Phe Leu Gly Asn Gln Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp 
            260                 265                 270         


Tyr Arg Val Asp Arg Gly Gly Arg His Pro Ser Ala His Asp Val Ile 
        275                 280                 285             


Leu Glu Gly Ala Gly Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly 
    290                 295                 300                 


Lys Thr Leu Pro Cys Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn 
305                 310                 315                 320 


Glu His Pro Ser Asn Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr 
                325                 330                 335     


Arg Arg Leu Leu Arg Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr 
            340                 345                 350         


Gly Glu Tyr Ser Thr Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala 
        355                 360                 365             


Arg Pro Val Ser Gly Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys 
    370                 375                 380                 


Pro Val Gly Tyr Lys Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr 
385                 390                 395                 400 


Lys Arg Asp Ser Ala Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys 
                405                 410                 415     


Asn Cys Gln Gly Gly Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr 
            420                 425                 430         


Ser Gly Asp Glu Asn Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly 
        435                 440                 445             


Phe Tyr Asn Asp Pro His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys 
    450                 455                 460                 


His Asn Gly Phe Ser Cys Ser Val Met Pro Glu Thr Glu Glu Val Val 
465                 470                 475                 480 


Cys Asn Asn Cys Pro Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys 
                485                 490                 495     


Ala Asp Gly Tyr Phe Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg 
            500                 505                 510         


Pro Cys Gln Pro Cys Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser 
        515                 520                 525             


Gly Asn Cys Asp Arg Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn 
    530                 535                 540                 


Thr Ala Gly Ile Tyr Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp 
545                 550                 555                 560 


Pro Leu Ala Pro Asn Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn 
                565                 570                 575     


Pro Met Gly Ser Glu Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val 
            580                 585                 590         


Cys Lys Pro Gly Phe Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser 
        595                 600                 605             


Cys Pro Ala Cys Tyr Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met 
    610                 615                 620                 


Gln Gln Leu Gln Arg Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly 
625                 630                 635                 640 


Asp Gly Val Val Pro Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala 
                645                 650                 655     


Glu Gln Ala Leu Gln Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly 
            660                 665                 670         


Ala Ser Arg Ser Leu Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu 
        675                 680                 685             


Asn Ser Tyr Gln Ser Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg 
    690                 695                 700                 


Val Arg Ala Leu Gly Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His 
705                 710                 715                 720 


Arg Leu Ile Thr Gln Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser 
                725                 730                 735     


Leu Gly Asn Thr Asn Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn 
            740                 745                 750         


Gly Phe Lys Ser Leu Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His 
        755                 760                 765             


Val Glu Ser Ala Ser Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp 
    770                 775                 780                 


Tyr Ser Lys Gln Ala Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly 
785                 790                 795                 800 


Val Gly Ser Gly Ser Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu 
                805                 810                 815     


Val Glu Lys Leu Glu Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg 
            820                 825                 830         


Glu Ala Thr Gln Ala Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser 
        835                 840                 845             


Leu Arg Leu Leu Asp Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln 
    850                 855                 860                 


Ser Phe Gln Val Glu Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser 
865                 870                 875                 880 


Leu Ser Thr Leu Val Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln 
                885                 890                 895     


Lys Asn Leu Gly Asn Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn 
            900                 905                 910         


Gly Lys Ser Gly Arg Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn 
        915                 920                 925             


Leu Ala Lys Ser Arg Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr 
    930                 935                 940                 


Phe Tyr Glu Val Glu Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu 
945                 950                 955                 960 


Gln Val Asp Asn Arg Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu 
                965                 970                 975     


Ser Tyr Ile Ser Gln Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln 
            980                 985                 990         


Ala Glu Arg Ala Leu Gly Ser Ala  Ala Ala Asp Ala Gln  Arg Ala Lys 
        995                 1000                 1005             


Asn Gly  Ala Gly Glu Ala Leu  Glu Ile Ser Ser Glu  Ile Glu Gln 
    1010                 1015                 1020             


Glu Ile  Gly Ser Leu Asn Leu  Glu Ala Asn Val Thr  Ala Asp Gly 
    1025                 1030                 1035             


Ala Leu  Ala Met Glu Lys Gly  Leu Ala Ser Leu Lys  Ser Glu Met 
    1040                 1045                 1050             


Arg Glu  Val Glu Gly Glu Leu  Glu Arg Lys Glu Leu  Glu Phe Asp 
    1055                 1060                 1065             


Thr Asn  Met Asp Ala Val Gln  Met Val Ile Thr Glu  Ala Gln Lys 
    1070                 1075                 1080             


Val Asp  Thr Arg Ala Lys Asn  Ala Gly Val Thr Ile  Gln Asp Thr 
    1085                 1090                 1095             


Leu Asn  Thr Leu Asp Gly Leu  Leu His Leu Met Asp  Gln Pro Leu 
    1100                 1105                 1110             


Ser Val  Asp Glu Glu Gly Leu  Val Leu Leu Glu Gln  Lys Leu Ser 
    1115                 1120                 1125             


Arg Ala  Lys Thr Gln Ile Asn  Ser Gln Leu Arg Pro  Met Met Ser 
    1130                 1135                 1140             


Glu Leu  Glu Glu Arg Ala Arg  Gln Gln Arg Gly His  Leu His Leu 
    1145                 1150                 1155             


Leu Glu  Thr Ser Ile Asp Gly  Ile Leu Ala Asp Val  Lys Asn Leu 
    1160                 1165                 1170             


Glu Asn  Ile Arg Asp Asn Leu  Pro Pro Gly Cys Tyr  Asn Thr Gln 
    1175                 1180                 1185             


Ala Leu  Glu Gln Gln 
    1190             


<210>  363
<211>  4297
<212>  DNA
<213>  Homosapiens

<400>  363
acagcggagc gcagagtgag aaccaccaac cgaggcgccg ggcagcgacc cctgcagcgg     60

agacagagac tgagcggccc ggcaccgcca tgcctgcgct ctggctgggc tgctgcctct    120

gcttctcgct cctcctgccc gcagcccggg ccacctccag gagggaagtc tgtgattgca    180

atgggaagtc caggcagtgt atctttgatc gggaacttca cagacaaact ggtaatggat    240

tccgctgcct caactgcaat gacaacactg atggcattca ctgcgagaag tgcaagaatg    300

gcttttaccg gcacagagaa agggaccgct gtttgccctg caattgtaac tccaaaggtt    360

ctcttagtgc tcgatgtgac aactctggac ggtgcagctg taaaccaggt gtgacaggag    420

ccagatgcga ccgatgtctg ccaggcttcc acatgctcac ggatgcgggg tgcacccaag    480

accagagact gctagactcc aagtgtgact gtgacccagc tggcatcgca gggccctgtg    540

acgcgggccg ctgtgtctgc aagccagctg ttactggaga acgctgtgat aggtgtcgat    600

caggttacta taatctggat ggggggaacc ctgagggctg tacccagtgt ttctgctatg    660

ggcattcagc cagctgccgc agctctgcag aatacagtgt ccataagatc acctctacct    720

ttcatcaaga tgttgatggc tggaaggctg tccaacgaaa tgggtctcct gcaaagctcc    780

aatggtcaca gcgccatcaa gatgtgttta gctcagccca acgactagac cctgtctatt    840

ttgtggctcc tgccaaattt cttgggaatc aacaggtgag ctatgggcaa agcctgtcct    900

ttgactaccg tgtggacaga ggaggcagac acccatctgc ccatgatgtg attctggaag    960

gtgctggtct acggatcaca gctcccttga tgccacttgg caagacactg ccttgtgggc   1020

tcaccaagac ttacacattc aggttaaatg agcatccaag caataattgg agcccccagc   1080

tgagttactt tgagtatcga aggttactgc ggaatctcac agccctccgc atccgagcta   1140

catatggaga atacagtact gggtacattg acaatgtgac cctgatttca gcccgccctg   1200

tctctggagc cccagcaccc tgggttgaac agtgtatatg tcctgttggg tacaaggggc   1260

aattctgcca ggattgtgct tctggctaca agagagattc agcgagactg gggccttttg   1320

gcacctgtat tccttgtaac tgtcaagggg gaggggcctg tgatccagac acaggagatt   1380

gttattcagg ggatgagaat cctgacattg agtgtgctga ctgcccaatt ggtttctaca   1440

acgatccgca cgacccccgc agctgcaagc catgtccctg tcataacggg ttcagctgct   1500

cagtgatgcc ggagacggag gaggtggtgt gcaataactg ccctcccggg gtcaccggtg   1560

cccgctgtga gctctgtgct gatggctact ttggggaccc ctttggtgaa catggcccag   1620

tgaggccttg tcagccctgt caatgcaaca acaatgtgga ccccagtgcc tctgggaatt   1680

gtgaccggct gacaggcagg tgtttgaagt gtatccacaa cacagccggc atctactgcg   1740

accagtgcaa agcaggctac ttcggggacc cattggctcc caacccagca gacaagtgtc   1800

gagcttgcaa ctgtaacccc atgggctcag agcctgtagg atgtcgaagt gatggcacct   1860

gtgtttgcaa gccaggattt ggtggcccca actgtgagca tggagcattc agctgtccag   1920

cttgctataa tcaagtgaag attcagatgg atcagtttat gcagcagctt cagagaatgg   1980

aggccctgat ttcaaaggct cagggtggtg atggagtagt acctgataca gagctggaag   2040

gcaggatgca gcaggctgag caggcccttc aggacattct gagagatgcc cagatttcag   2100

aaggtgctag cagatccctt ggtctccagt tggccaaggt gaggagccaa gagaacagct   2160

accagagccg cctggatgac ctcaagatga ctgtggaaag agttcgggct ctgggaagtc   2220

agtaccagaa ccgagttcgg gatactcaca ggctcatcac tcagatgcag ctgagcctgg   2280

cagaaagtga agcttccttg ggaaacacta acattcctgc ctcagaccac tacgtggggc   2340

caaatggctt taaaagtctg gctcaggagg ccacaagatt agcagaaagc cacgttgagt   2400

cagccagtaa catggagcaa ctgacaaggg aaactgagga ctattccaaa caagccctct   2460

cactggtgcg caaggccctg catgaaggag tcggaagcgg aagcggtagc ccggacggtg   2520

ctgtggtgca agggcttgtg gaaaaattgg agaaaaccaa gtccctggcc cagcagttga   2580

caagggaggc cactcaagcg gaaattgaag cagataggtc ttatcagcac agtctccgcc   2640

tcctggattc agtgtctcgg cttcagggag tcagtgatca gtcctttcag gtggaagaag   2700

caaagaggat caaacaaaaa gcggattcac tctcaacgct ggtaaccagg catatggatg   2760

agttcaagcg tacacaaaag aatctgggaa actggaaaga agaagcacag cagctcttac   2820

agaatggaaa aagtgggaga gagaaatcag atcagctgct ttcccgtgcc aatcttgcta   2880

aaagcagagc acaagaagca ctgagtatgg gcaatgccac tttttatgaa gttgagagca   2940

tccttaaaaa cctcagagag tttgacctgc aggtggacaa cagaaaagca gaagctgaag   3000

aagccatgaa gagactctcc tacatcagcc agaaggtttc agatgccagt gacaagaccc   3060

agcaagcaga aagagccctg gggagcgctg ctgctgatgc acagagggca aagaatgggg   3120

ccggggaggc cctggaaatc tccagtgaga ttgaacagga gattgggagt ctgaacttgg   3180

aagccaatgt gacagcagat ggagccttgg ccatggaaaa gggactggcc tctctgaaga   3240

gtgagatgag ggaagtggaa ggagagctgg aaaggaagga gctggagttt gacacgaata   3300

tggatgcagt acagatggtg attacagaag cccagaaggt tgataccaga gccaagaacg   3360

ctggggttac aatccaagac acactcaaca cattagacgg cctcctgcat ctgatgggta   3420

tgtgaaccca caacccacaa ccttccagct ccatgctcca gggctttgct ccagaacact   3480

cactatacct agccccagca aaggggagtc tcagctttcc ttaaggatat cagtaaatgt   3540

gctttgtttc caggcccaga taactttcgg caggttccct tacatttact ggaccctgtt   3600

ttaccgttgc taagatgggt cactgaacac ctattgcact tgggggtaaa ggtctgtggg   3660

ccaaagaaca ggtgtatata agcaacttca cagaacacga gacagcttgg gaatcctgct   3720

aaagagtctg gcctggaccc tgagaagcca gtggacagtt ttaagcagag gaataacatc   3780

accactgtat atttcagaaa gatcactagg gcagccgagt ggaggaaagc ttgaagaggg   3840

ggttagagag aaggcaggtt gagactactt aagatattgt tgaaataatt gaagagagaa   3900

atgacaggag cctgctctaa ggcagtagaa tggtggctgg gaagatgtga aggaagattt   3960

tcccagtctg tgaagtcaag aatcacttgc cggccgggtg tggtggctca cgcctgtaat   4020

tctagcactt tgggagactg aagcgggtgg atcacccgag gtcaggagtt gaagaccagc   4080

ctggccaaca tggtgaaacc ctgtctctac taaaagtaca aaaattagct ggatgtggtg   4140

gtgggcgcct gtaattccag ctactcagga gtctgaggca ggagaatcgc ttgaacccag   4200

gaggcggagg ttacagtgag ccaagattgc accactgctc tccagcctgg ggaacagagc   4260

aagactgtct caaaaaaaaa aaaaaaagga aaaataa                            4297


<210>  364
<211>  1111
<212>  PRT
<213>  Homosapiens

<400>  364

Met Pro Ala Leu Trp Leu Gly Cys Cys Leu Cys Phe Ser Leu Leu Leu 
1               5                   10                  15      


Pro Ala Ala Arg Ala Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly 
            20                  25                  30          


Lys Ser Arg Gln Cys Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly 
        35                  40                  45              


Asn Gly Phe Arg Cys Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His 
    50                  55                  60                  


Cys Glu Lys Cys Lys Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg 
65                  70                  75                  80  


Cys Leu Pro Cys Asn Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys 
                85                  90                  95      


Asp Asn Ser Gly Arg Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg 
            100                 105                 110         


Cys Asp Arg Cys Leu Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys 
        115                 120                 125             


Thr Gln Asp Gln Arg Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala 
    130                 135                 140                 


Gly Ile Ala Gly Pro Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala 
145                 150                 155                 160 


Val Thr Gly Glu Arg Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu 
                165                 170                 175     


Asp Gly Gly Asn Pro Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His 
            180                 185                 190         


Ser Ala Ser Cys Arg Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr 
        195                 200                 205             


Ser Thr Phe His Gln Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn 
    210                 215                 220                 


Gly Ser Pro Ala Lys Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe 
225                 230                 235                 240 


Ser Ser Ala Gln Arg Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys 
                245                 250                 255     


Phe Leu Gly Asn Gln Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp 
            260                 265                 270         


Tyr Arg Val Asp Arg Gly Gly Arg His Pro Ser Ala His Asp Val Ile 
        275                 280                 285             


Leu Glu Gly Ala Gly Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly 
    290                 295                 300                 


Lys Thr Leu Pro Cys Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn 
305                 310                 315                 320 


Glu His Pro Ser Asn Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr 
                325                 330                 335     


Arg Arg Leu Leu Arg Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr 
            340                 345                 350         


Gly Glu Tyr Ser Thr Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala 
        355                 360                 365             


Arg Pro Val Ser Gly Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys 
    370                 375                 380                 


Pro Val Gly Tyr Lys Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr 
385                 390                 395                 400 


Lys Arg Asp Ser Ala Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys 
                405                 410                 415     


Asn Cys Gln Gly Gly Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr 
            420                 425                 430         


Ser Gly Asp Glu Asn Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly 
        435                 440                 445             


Phe Tyr Asn Asp Pro His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys 
    450                 455                 460                 


His Asn Gly Phe Ser Cys Ser Val Met Pro Glu Thr Glu Glu Val Val 
465                 470                 475                 480 


Cys Asn Asn Cys Pro Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys 
                485                 490                 495     


Ala Asp Gly Tyr Phe Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg 
            500                 505                 510         


Pro Cys Gln Pro Cys Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser 
        515                 520                 525             


Gly Asn Cys Asp Arg Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn 
    530                 535                 540                 


Thr Ala Gly Ile Tyr Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp 
545                 550                 555                 560 


Pro Leu Ala Pro Asn Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn 
                565                 570                 575     


Pro Met Gly Ser Glu Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val 
            580                 585                 590         


Cys Lys Pro Gly Phe Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser 
        595                 600                 605             


Cys Pro Ala Cys Tyr Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met 
    610                 615                 620                 


Gln Gln Leu Gln Arg Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly 
625                 630                 635                 640 


Asp Gly Val Val Pro Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala 
                645                 650                 655     


Glu Gln Ala Leu Gln Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly 
            660                 665                 670         


Ala Ser Arg Ser Leu Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu 
        675                 680                 685             


Asn Ser Tyr Gln Ser Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg 
    690                 695                 700                 


Val Arg Ala Leu Gly Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His 
705                 710                 715                 720 


Arg Leu Ile Thr Gln Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser 
                725                 730                 735     


Leu Gly Asn Thr Asn Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn 
            740                 745                 750         


Gly Phe Lys Ser Leu Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His 
        755                 760                 765             


Val Glu Ser Ala Ser Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp 
    770                 775                 780                 


Tyr Ser Lys Gln Ala Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly 
785                 790                 795                 800 


Val Gly Ser Gly Ser Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu 
                805                 810                 815     


Val Glu Lys Leu Glu Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg 
            820                 825                 830         


Glu Ala Thr Gln Ala Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser 
        835                 840                 845             


Leu Arg Leu Leu Asp Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln 
    850                 855                 860                 


Ser Phe Gln Val Glu Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser 
865                 870                 875                 880 


Leu Ser Thr Leu Val Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln 
                885                 890                 895     


Lys Asn Leu Gly Asn Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn 
            900                 905                 910         


Gly Lys Ser Gly Arg Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn 
        915                 920                 925             


Leu Ala Lys Ser Arg Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr 
    930                 935                 940                 


Phe Tyr Glu Val Glu Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu 
945                 950                 955                 960 


Gln Val Asp Asn Arg Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu 
                965                 970                 975     


Ser Tyr Ile Ser Gln Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln 
            980                 985                 990         


Ala Glu Arg Ala Leu Gly Ser Ala  Ala Ala Asp Ala Gln  Arg Ala Lys 
        995                 1000                 1005             


Asn Gly  Ala Gly Glu Ala Leu  Glu Ile Ser Ser Glu  Ile Glu Gln 
    1010                 1015                 1020             


Glu Ile  Gly Ser Leu Asn Leu  Glu Ala Asn Val Thr  Ala Asp Gly 
    1025                 1030                 1035             


Ala Leu  Ala Met Glu Lys Gly  Leu Ala Ser Leu Lys  Ser Glu Met 
    1040                 1045                 1050             


Arg Glu  Val Glu Gly Glu Leu  Glu Arg Lys Glu Leu  Glu Phe Asp 
    1055                 1060                 1065             


Thr Asn  Met Asp Ala Val Gln  Met Val Ile Thr Glu  Ala Gln Lys 
    1070                 1075                 1080             


Val Asp  Thr Arg Ala Lys Asn  Ala Gly Val Thr Ile  Gln Asp Thr 
    1085                 1090                 1095             


Leu Asn  Thr Leu Asp Gly Leu  Leu His Leu Met Gly  Met 
    1100                 1105                 1110     


<210>  365
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  365
ggagccgcgg ggcttccatc cttcctttga ctgattttta aattttaatt tgtattttcc     60

ccgccgcccc gccccttttc ctccgacccc gccctatcgc tccccggctt ccctgctctt    120

tcctttttcc cggcttcctt cctcgcgttt ctttcccctg cgccctcggc ttgcctctct    180

ccctcctccc tcgctctctc ccccttctct ccccttcttc ctcggtttct tccgtcctct    240

ctctccccct cctcctcccc cgcctcctcc tcctgcgctc ccgccccctg ccccctcccc    300

ccgtgcctgc agacgcgcgg atcgtccatg cgctcctcgc gggcagaatg ctgggcagca    360

gcgtcaagag cgtgcagccc gaggtggagc tgagcagcgg cggcggcgac gagggcgcgg    420

acgaaccgcg gggcgccggc aggaaggcgg cagcggcgga cggcagaggc atgctgccca    480

agcgcgccaa ggcgcccggc ggcggcggcg gcatggccaa ggccagcgcg gctgagctga    540

aggtcttcaa gtccggcagc gtggacagcc gtgtccccgg cgggccgccc gcctccaacc    600

tgcgcaagca gaagtcactc accaacctct cttttctcac ggactccgag aaaaagctgc    660

agctttatga gcccgaatgg agcgacgata tggccaaggc gcccaaaggc ttaggcaagg    720

tggggtccaa gggccgtgaa gctccgctga tgtccaagac gctgtccaag tcggagcact    780

cgctcttcca ggccaagggc agcccggcgg gcggtgccaa gacccccctg gctccgctcg    840

cgcccaacct gggaaagccg agccggatcc ctcgaggacc ctatgcggag gtcaagccgc    900

tcagcaaggc gcctgaagcg gccgtgagcg aagatggcaa atcggacgac gagctgctct    960

ccagcaaggc caaggcgcaa aagagctctg ggcctgtccc ctctgccaag ggccaggagg   1020

agcgcgcctt cctcaaggtg gaccccgagc tggtggtgac cgtgctggga gacctggagc   1080

agctgctctt cagccagatg ctggacccag agtcccagag aaagaggaca gtgcagaatg   1140

tcctggatct ccggcagaac ctggaagaga ccatgtccag cctgcgaggg tcccaggtga   1200

ctcacagctc cctggagatg acctgctacg acagcgatga tgccaaccca cgcagcgtgt   1260

ccagcctctc caaccgctcg tcccctctgt catggcgcta tggccagtcc agtccgcggc   1320

tgcaggctgg tgacgcgccc tctgtgggtg ggagctgccg ctcggagggg acgcccgcct   1380

ggtacatgca cggcgaacgg gcccactact cccacaccat gcccatgcgc agccccagca   1440

agctcagcca tatctcccgc ctggagctgg tcgaatccct ggactcggat gaggtggacc   1500

tcaagtccgg ctacatgagc gacagtgacc tcatgggcaa gaccatgacg gaggatgatg   1560

acatcactac cggctgggat gaaagcagct ccatcagtag tggactcagc gatgcctcag   1620

acaatctcag ttcagaagaa ttcaatgcca gctcctcact caactccctc ccaagtactc   1680

ccactgcttc tcgcaggaac tcaacaatag tgctacgcac agactcagag aagcgctcac   1740

tggcagaaag tgggctgagc tggtttagtg aatcagagga gaaagcccct aaaaaactgg   1800

agtacgacag tggtagcctg aagatggaac ctgggacttc taagtggcgg agggagcggc   1860

ctgagagctg tgatgattca tccaagggtg gagaactgaa aaagcccatc agcctgggcc   1920

accctggttc cctgaagaag ggcaagaccc cacctgtggc tgtaacttcc cccatcactc   1980

acacagccca gagtgccctc aaagtcgcag gcaaacctga gggcaaagct acagacaagg   2040

gtaagcttgc agtgaagaat actgggctcc aacgctcctc ctctgatgct ggtcgggacc   2100

gcctgagtga tgctaagaag cccccctcgg gcattgctcg cccctccact tcgggatcct   2160

ttggctacaa gaagcctcct cctgccacag gcacagccac tgtcatgcaa actggtggtt   2220

cagccactct cagcaagatc cagaagtcct caggcatccc tgtcaagcca gtaaatgggc   2280

gcaagactag cttagatgtt tccaacagtg cagagccagg attcctggct cctggagccc   2340

gttctaacat ccagtaccgc agcctgcccc ggccagccaa gtcaagttct atgagcgtga   2400

ccggcgggcg gggtggacct cgccctgtga gcagcagcat tgaccccagt ctcctcagca   2460

ccaagcaggg aggccttacg ccttccagac tgaaggagcc taccaaggta gccagtgggc   2520

ggaccactcc agcccctgtc aatcagacag atcgggaaaa ggagaaggcc aaagccaagg   2580

cagtggcctt ggactcagac aacatctcct tgaagagtat tggctcccca gaaagtactc   2640

ccaagaacca agcaagccac cccacagcca ccaagctggc agagctgcca ccaacccctc   2700

tcagggccac agcgaagagc tttgtcaaac caccctcact agccaatctt gacaaggtca   2760

actccaacag tctggatcta ccatcatcca gtgataccac ccatgcttca aaggtcccag   2820

atctgcatgc tacaagctca gcatctgggg gccctctccc ttcctgcttc acccccagtc   2880

cggcacccat cctcaatatt aactcagcca gcttctccca gggcctggag ctaatgagtg   2940

gtttcagtgt gccaaaagag acccgcatgt accccaaact ctcaggcctg cacaggagca   3000

tggagtccct ccagatgcca atgagcctcc ccagtgcctt ccccagcagt actcccgtcc   3060

ccaccccacc tgctccccct gctgctccca cagaagaaga gacggaagag ctgacttgga   3120

gtggaagccc cagagctggg caactggaca gtaatcagcg ggatcggaac actcttccca   3180

agaaagggct caggtaccag cttcagtccc aggaggagac caaggagagg cgacattccc   3240

ataccattgg tgggctgcct gaatccgatg accagtcaga gctgccttct ccccctgcac   3300

ttcccatgtc tctgagtgca aagggccaac ttaccaacat agtgagtccc actgcggcca   3360

ccacgccaag aatcacccgc tccaacagca tccccaccca cgaggcggcc ttcgagctgt   3420

acagcggctc ccaaatgggg agcaccctgt ccctggccga gagacccaag ggaatgattc   3480

ggtcaggatc cttccgagac cccacggacg atgttcacgg ctcagtgctg tccctggcct   3540

ccagtgcctc ctccacctac tcctcagctg aggagaggat gcaatctgag caaatccgga   3600

agcttcgtag ggaactggaa tcatcccagg aaaaagtggc caccttgacg tctcagcttt   3660

ctgccaatgc taatctggtg gctgcttttg agcagagcct ggtgaatatg acatcccgcc   3720

tgcgacacct ggcagagacg gccgaggaga aggacactga gctgctggat ttgcgagaaa   3780

ccatagactt tctgaagaaa aagaactctg aggcccaggc agtcattcag ggagccctta   3840

atgcctcaga aaccacaccc aaagaacttc ggatcaagag acaaaactcc tcagatagca   3900

tctcaagcct caacagcatc actagccatt ccagcatcgg cagcagcaag gatgctgatg   3960

cgaaaaagaa gaaaaaaaag agttggcttc gaagttcctt caacaaagcg ttcagtataa   4020

aaaaggggcc caagtcagct tcctcatact cggatataga ggagattgct acacccgact   4080

cttcagcccc ctcatccccc aaactacagc atggttctac agagactgct tcaccctcca   4140

tcaagtcctc cacctcgtcc tccgtgggca ctgatgtcac cgagggccct gctcacccag   4200

ccccccacac taggctgttc catgcaaatg aggaggagga gccagagaag aaggaggtat   4260

cggagctgcg ctctgagcta tgggagaagg aaatgaagct tacagacatc cgcttggagg   4320

ccctcaactc tgcccaccaa ctggatcagc ttcgggagac catgcacaac atgcagttgg   4380

aggtggacct gctgaaagca gagaatgacc gactgaaggt agccccaggc ccctcatcag   4440

gctccactcc agggcaggtc cctggatcat ctgcattatc ttccccacgc cgctccctag   4500

gcctggcact cacccattcc ttcggcccca gtcttgcaga cacagacctg tcacccatgg   4560

atggcatcag tacttgtggt ccaaaggagg aagtgaccct ccgggtggtg gtgaggatgc   4620

ccccgcagca catcatcaaa ggggacttga agcagcagga attcttcctg ggctgtagca   4680

aggtcagtgg aaaagttgac tggaagatgc tggatgaagc tgttttccaa gtgttcaagg   4740

actatatttc taaaatggac ccagcctcta ccctgggact aagcactgag tccatccatg   4800

gctacagcat cagccacgtg aaacgagtgt tggatgcaga gccccccgag atgcctcctt   4860

gccgtcgagg tgtcaataac atatcagtct ccctcaaagg tctgaaggag aaatgcgtcg   4920

acagcctggt gttcgagacg ctgatcccca agccgatgat gcagcactac ataagcctcc   4980

tgctgaagca ccggcgcctc gtcctctcgg gccccagcgg cacgggcaag acctacctga   5040

ccaatcgctt ggccgagtac ctggtggagc gctctggccg tgaggtcaca gagggcatcg   5100

tcagcacctt caacatgcac cagcagtctt gcaaggatct gcaactgtat ctttccaacc   5160

tagccaacca gatagaccgg gaaacaggaa ttggggatgt gcccctggtg attctattgg   5220

atgacctgag tgaagcaggc tccatcagtg agttggtcaa tggggccctc acctgcaagt   5280

atcataaatg tccctatatt ataggtacca ccaatcagcc tgtaaaaatg acacccaacc   5340

atggcttgca cttgagcttc aggatgttga ccttctccaa caacgtggag ccagccaatg   5400

gcttcctggt tcgttacctg aggaggaagc tggtagagtc agacagcgac atcaatgcca   5460

acaaggaaga gctgcttcgg gtgctcgact gggtacccaa gctgtggtat catctccaca   5520

ccttccttga gaagcacagc acctcagact tcctcatcgg cccttgcttc tttctgtcgt   5580

gtcccattgg cattgaggac ttccggacct ggttcattga cctgtggaac aactctatca   5640

ttccctatct acaggaagga gccaaggatg ggataaaggt ccatggacag aaagctgctt   5700

gggaggaccc agtggaatgg gtccgggaca cacttccctg gccatcagcc caacaagacc   5760

aatcaaagct gtaccacctg cccccaccca ccgtgggccc tcacagcatt gcctcacctc   5820

ccgaggatag gacagtcaaa gacagcaccc caagttctct ggactcagat cctctgatgg   5880

ccatgctgct gaaacttcaa gaagctgcca actacattga gtctccagat cgagaaacca   5940

tcctggaccc caaccttcag gcaacacttt aagggttcgg caatcactgt cacccccgga   6000

cagcagaacg ctggcatcag ctatcttagc tcctcctctc ccctctcctc tttcagagca   6060

ctggctctcc agccccagga ggagaacagg agggaggagg agatgaaaga ggagggacag   6120

gttcttggtg ctgtaccttt gagaacttcc taggaaggaa tggtggggtg gcgtttggga   6180

acttgtgccc cctaaacaca tttactggcc tcctctaatg actttgggga aaagatgatt   6240

ctgggtcttt cccttgactt cttgtttcaa ttacaaactc ctgggctttc tggggagggg   6300

ttcagaaaac atcaaaacac tgcagcagtt cctaaatgat tctcacaagc aaccctgaga   6360

gagacagtct tgtgagggag atctggggga ggcaggaagc tcctcagatt ttctcacaga   6420

cccttcccaa ttccatcacc actgccaaca actcctcccc cagagatctg gctggagccc   6480

agaaaaagaa gcatgtggtt taaaaaatgt ttaaatcaat ctgtaaaagg taaaaatgaa   6540

aaacaaaaac aagcaaacaa acaaaaaaca atggaaaaga tgaagctgga gagagaggaa   6600

ccagttgcca aggtagagag ctgcccgctc ctgccctctg gatgacatag gggacatcaa   6660

caagacggct gccaacctga gaagtcacca aaccacaaaa ataaccttac agccttcagg   6720

gaaagactac cagctctgtc tttctaccct ctaatttaac aatgcataag agtcaataaa   6780

ccctactttt ttatttttgg tttttatttt gttttcattt ttttctccca tttgcctatt   6840

tatttttttg tttccctttt ttttttcttt ttccgttttt ccatttcctc acatgtccac   6900

gagatgcttg ggttgctttt ccaggggcta gtttggcttt tccaagtggg ttttctttgg   6960

agaatctgat gccatgcaat tggcatgaca cctgccatgc cactatcttt ggcatccatg   7020

gggcttatat gagacatgaa gcattggctc agaagtagag ggagaagagg aacccagttc   7080

ccttgacttc ccttttgaga gcacacgttc tgctgggtag ctcaattgcc agcctctgtc   7140

atgagaaggt atagccccat cttgatagaa gagttactcc gagctttatc atggaccaga   7200

ggaaaaccag aaaactgaaa acattcctct gtcttgtggc cagtttggcc tttcactgca   7260

ctattctgat ggtgcctgac tgaatccaaa tatcctagct ggctcttact atttttcaca   7320

aatgagtatt cacatataag agatgaacat ccatgtgaga tcatcccaat cagaatataa   7380

gactcaagga gtttgacttg gtggccaata cctgccttcc aaagagatcc tacctttgca   7440

gatttgctcc tttcccattg ccttgaaggt ctggcaatcc ctgttctttc atttgacaag   7500

tacttactga gtactcacta tatacaaatc attaggttaa aacagacaca cacacacaca   7560

cacacacaca cacacacaca cacacacaca agacctgggc ccttaagttt acagtccagc   7620

aggaaatgtt aacctccatt cagctacgcc cccttgttat ctagaccttc gggatcatct   7680

aagaaatgta gctgaaaccc aaggagccag ctagaaagaa gcttttgatt agatgtacaa   7740

tacattgggg gcagaagatc tgggatcaat taagatggag cctgaaggac tatggaatct   7800

tgcttgtcag gaatgggcaa gtctacttcc tgccatttct gaaagccccg cgggaccagc   7860

ttctaggctg agctgcctag taggctgaag cttcaggact ctgcaggtca aggatatgtg   7920

atgagcaccg gcctaagtgt ttgctcttca gattcctaag tagcacaaga ctttatcaga   7980

atctataggc ataccaacct ggatcactct tccacccaac cgaggagtag atgcatctga   8040

atcttcatat cggtatatta agtccaaaag atggtccggg ctgcccctca caaaagcttc   8100

tgcatccacg tggtaagctc ccatggatga cagggttctg tatgatggag actattattg   8160

ctattgctgc taattccatg agctgtgaag at                                 8192


<210>  366
<211>  1874
<212>  PRT
<213>  Homosapiens

<400>  366

Met Leu Gly Ser Ser Val Lys Ser Val Gln Pro Glu Val Glu Leu Ser 
1               5                   10                  15      


Ser Gly Gly Gly Asp Glu Gly Ala Asp Glu Pro Arg Gly Ala Gly Arg 
            20                  25                  30          


Lys Ala Ala Ala Ala Asp Gly Arg Gly Met Leu Pro Lys Arg Ala Lys 
        35                  40                  45              


Ala Pro Gly Gly Gly Gly Gly Met Ala Lys Ala Ser Ala Ala Glu Leu 
    50                  55                  60                  


Lys Val Phe Lys Ser Gly Ser Val Asp Ser Arg Val Pro Gly Gly Pro 
65                  70                  75                  80  


Pro Ala Ser Asn Leu Arg Lys Gln Lys Ser Leu Thr Asn Leu Ser Phe 
                85                  90                  95      


Leu Thr Asp Ser Glu Lys Lys Leu Gln Leu Tyr Glu Pro Glu Trp Ser 
            100                 105                 110         


Asp Asp Met Ala Lys Ala Pro Lys Gly Leu Gly Lys Val Gly Ser Lys 
        115                 120                 125             


Gly Arg Glu Ala Pro Leu Met Ser Lys Thr Leu Ser Lys Ser Glu His 
    130                 135                 140                 


Ser Leu Phe Gln Ala Lys Gly Ser Pro Ala Gly Gly Ala Lys Thr Pro 
145                 150                 155                 160 


Leu Ala Pro Leu Ala Pro Asn Leu Gly Lys Pro Ser Arg Ile Pro Arg 
                165                 170                 175     


Gly Pro Tyr Ala Glu Val Lys Pro Leu Ser Lys Ala Pro Glu Ala Ala 
            180                 185                 190         


Val Ser Glu Asp Gly Lys Ser Asp Asp Glu Leu Leu Ser Ser Lys Ala 
        195                 200                 205             


Lys Ala Gln Lys Ser Ser Gly Pro Val Pro Ser Ala Lys Gly Gln Glu 
    210                 215                 220                 


Glu Arg Ala Phe Leu Lys Val Asp Pro Glu Leu Val Val Thr Val Leu 
225                 230                 235                 240 


Gly Asp Leu Glu Gln Leu Leu Phe Ser Gln Met Leu Asp Pro Glu Ser 
                245                 250                 255     


Gln Arg Lys Arg Thr Val Gln Asn Val Leu Asp Leu Arg Gln Asn Leu 
            260                 265                 270         


Glu Glu Thr Met Ser Ser Leu Arg Gly Ser Gln Val Thr His Ser Ser 
        275                 280                 285             


Leu Glu Met Thr Cys Tyr Asp Ser Asp Asp Ala Asn Pro Arg Ser Val 
    290                 295                 300                 


Ser Ser Leu Ser Asn Arg Ser Ser Pro Leu Ser Trp Arg Tyr Gly Gln 
305                 310                 315                 320 


Ser Ser Pro Arg Leu Gln Ala Gly Asp Ala Pro Ser Val Gly Gly Ser 
                325                 330                 335     


Cys Arg Ser Glu Gly Thr Pro Ala Trp Tyr Met His Gly Glu Arg Ala 
            340                 345                 350         


His Tyr Ser His Thr Met Pro Met Arg Ser Pro Ser Lys Leu Ser His 
        355                 360                 365             


Ile Ser Arg Leu Glu Leu Val Glu Ser Leu Asp Ser Asp Glu Val Asp 
    370                 375                 380                 


Leu Lys Ser Gly Tyr Met Ser Asp Ser Asp Leu Met Gly Lys Thr Met 
385                 390                 395                 400 


Thr Glu Asp Asp Asp Ile Thr Thr Gly Trp Asp Glu Ser Ser Ser Ile 
                405                 410                 415     


Ser Ser Gly Leu Ser Asp Ala Ser Asp Asn Leu Ser Ser Glu Glu Phe 
            420                 425                 430         


Asn Ala Ser Ser Ser Leu Asn Ser Leu Pro Ser Thr Pro Thr Ala Ser 
        435                 440                 445             


Arg Arg Asn Ser Thr Ile Val Leu Arg Thr Asp Ser Glu Lys Arg Ser 
    450                 455                 460                 


Leu Ala Glu Ser Gly Leu Ser Trp Phe Ser Glu Ser Glu Glu Lys Ala 
465                 470                 475                 480 


Pro Lys Lys Leu Glu Tyr Asp Ser Gly Ser Leu Lys Met Glu Pro Gly 
                485                 490                 495     


Thr Ser Lys Trp Arg Arg Glu Arg Pro Glu Ser Cys Asp Asp Ser Ser 
            500                 505                 510         


Lys Gly Gly Glu Leu Lys Lys Pro Ile Ser Leu Gly His Pro Gly Ser 
        515                 520                 525             


Leu Lys Lys Gly Lys Thr Pro Pro Val Ala Val Thr Ser Pro Ile Thr 
    530                 535                 540                 


His Thr Ala Gln Ser Ala Leu Lys Val Ala Gly Lys Pro Glu Gly Lys 
545                 550                 555                 560 


Ala Thr Asp Lys Gly Lys Leu Ala Val Lys Asn Thr Gly Leu Gln Arg 
                565                 570                 575     


Ser Ser Ser Asp Ala Gly Arg Asp Arg Leu Ser Asp Ala Lys Lys Pro 
            580                 585                 590         


Pro Ser Gly Ile Ala Arg Pro Ser Thr Ser Gly Ser Phe Gly Tyr Lys 
        595                 600                 605             


Lys Pro Pro Pro Ala Thr Gly Thr Ala Thr Val Met Gln Thr Gly Gly 
    610                 615                 620                 


Ser Ala Thr Leu Ser Lys Ile Gln Lys Ser Ser Gly Ile Pro Val Lys 
625                 630                 635                 640 


Pro Val Asn Gly Arg Lys Thr Ser Leu Asp Val Ser Asn Ser Ala Glu 
                645                 650                 655     


Pro Gly Phe Leu Ala Pro Gly Ala Arg Ser Asn Ile Gln Tyr Arg Ser 
            660                 665                 670         


Leu Pro Arg Pro Ala Lys Ser Ser Ser Met Ser Val Thr Gly Gly Arg 
        675                 680                 685             


Gly Gly Pro Arg Pro Val Ser Ser Ser Ile Asp Pro Ser Leu Leu Ser 
    690                 695                 700                 


Thr Lys Gln Gly Gly Leu Thr Pro Ser Arg Leu Lys Glu Pro Thr Lys 
705                 710                 715                 720 


Val Ala Ser Gly Arg Thr Thr Pro Ala Pro Val Asn Gln Thr Asp Arg 
                725                 730                 735     


Glu Lys Glu Lys Ala Lys Ala Lys Ala Val Ala Leu Asp Ser Asp Asn 
            740                 745                 750         


Ile Ser Leu Lys Ser Ile Gly Ser Pro Glu Ser Thr Pro Lys Asn Gln 
        755                 760                 765             


Ala Ser His Pro Thr Ala Thr Lys Leu Ala Glu Leu Pro Pro Thr Pro 
    770                 775                 780                 


Leu Arg Ala Thr Ala Lys Ser Phe Val Lys Pro Pro Ser Leu Ala Asn 
785                 790                 795                 800 


Leu Asp Lys Val Asn Ser Asn Ser Leu Asp Leu Pro Ser Ser Ser Asp 
                805                 810                 815     


Thr Thr His Ala Ser Lys Val Pro Asp Leu His Ala Thr Ser Ser Ala 
            820                 825                 830         


Ser Gly Gly Pro Leu Pro Ser Cys Phe Thr Pro Ser Pro Ala Pro Ile 
        835                 840                 845             


Leu Asn Ile Asn Ser Ala Ser Phe Ser Gln Gly Leu Glu Leu Met Ser 
    850                 855                 860                 


Gly Phe Ser Val Pro Lys Glu Thr Arg Met Tyr Pro Lys Leu Ser Gly 
865                 870                 875                 880 


Leu His Arg Ser Met Glu Ser Leu Gln Met Pro Met Ser Leu Pro Ser 
                885                 890                 895     


Ala Phe Pro Ser Ser Thr Pro Val Pro Thr Pro Pro Ala Pro Pro Ala 
            900                 905                 910         


Ala Pro Thr Glu Glu Glu Thr Glu Glu Leu Thr Trp Ser Gly Ser Pro 
        915                 920                 925             


Arg Ala Gly Gln Leu Asp Ser Asn Gln Arg Asp Arg Asn Thr Leu Pro 
    930                 935                 940                 


Lys Lys Gly Leu Arg Tyr Gln Leu Gln Ser Gln Glu Glu Thr Lys Glu 
945                 950                 955                 960 


Arg Arg His Ser His Thr Ile Gly Gly Leu Pro Glu Ser Asp Asp Gln 
                965                 970                 975     


Ser Glu Leu Pro Ser Pro Pro Ala Leu Pro Met Ser Leu Ser Ala Lys 
            980                 985                 990         


Gly Gln Leu Thr Asn Ile Val Ser  Pro Thr Ala Ala Thr  Thr Pro Arg 
        995                 1000                 1005             


Ile Thr  Arg Ser Asn Ser Ile  Pro Thr His Glu Ala  Ala Phe Glu 
    1010                 1015                 1020             


Leu Tyr  Ser Gly Ser Gln Met  Gly Ser Thr Leu Ser  Leu Ala Glu 
    1025                 1030                 1035             


Arg Pro  Lys Gly Met Ile Arg  Ser Gly Ser Phe Arg  Asp Pro Thr 
    1040                 1045                 1050             


Asp Asp  Val His Gly Ser Val  Leu Ser Leu Ala Ser  Ser Ala Ser 
    1055                 1060                 1065             


Ser Thr  Tyr Ser Ser Ala Glu  Glu Arg Met Gln Ser  Glu Gln Ile 
    1070                 1075                 1080             


Arg Lys  Leu Arg Arg Glu Leu  Glu Ser Ser Gln Glu  Lys Val Ala 
    1085                 1090                 1095             


Thr Leu  Thr Ser Gln Leu Ser  Ala Asn Ala Asn Leu  Val Ala Ala 
    1100                 1105                 1110             


Phe Glu  Gln Ser Leu Val Asn  Met Thr Ser Arg Leu  Arg His Leu 
    1115                 1120                 1125             


Ala Glu  Thr Ala Glu Glu Lys  Asp Thr Glu Leu Leu  Asp Leu Arg 
    1130                 1135                 1140             


Glu Thr  Ile Asp Phe Leu Lys  Lys Lys Asn Ser Glu  Ala Gln Ala 
    1145                 1150                 1155             


Val Ile  Gln Gly Ala Leu Asn  Ala Ser Glu Thr Thr  Pro Lys Glu 
    1160                 1165                 1170             


Leu Arg  Ile Lys Arg Gln Asn  Ser Ser Asp Ser Ile  Ser Ser Leu 
    1175                 1180                 1185             


Asn Ser  Ile Thr Ser His Ser  Ser Ile Gly Ser Ser  Lys Asp Ala 
    1190                 1195                 1200             


Asp Ala  Lys Lys Lys Lys Lys  Lys Ser Trp Leu Arg  Ser Ser Phe 
    1205                 1210                 1215             


Asn Lys  Ala Phe Ser Ile Lys  Lys Gly Pro Lys Ser  Ala Ser Ser 
    1220                 1225                 1230             


Tyr Ser  Asp Ile Glu Glu Ile  Ala Thr Pro Asp Ser  Ser Ala Pro 
    1235                 1240                 1245             


Ser Ser  Pro Lys Leu Gln His  Gly Ser Thr Glu Thr  Ala Ser Pro 
    1250                 1255                 1260             


Ser Ile  Lys Ser Ser Thr Ser  Ser Ser Val Gly Thr  Asp Val Thr 
    1265                 1270                 1275             


Glu Gly  Pro Ala His Pro Ala  Pro His Thr Arg Leu  Phe His Ala 
    1280                 1285                 1290             


Asn Glu  Glu Glu Glu Pro Glu  Lys Lys Glu Val Ser  Glu Leu Arg 
    1295                 1300                 1305             


Ser Glu  Leu Trp Glu Lys Glu  Met Lys Leu Thr Asp  Ile Arg Leu 
    1310                 1315                 1320             


Glu Ala  Leu Asn Ser Ala His  Gln Leu Asp Gln Leu  Arg Glu Thr 
    1325                 1330                 1335             


Met His  Asn Met Gln Leu Glu  Val Asp Leu Leu Lys  Ala Glu Asn 
    1340                 1345                 1350             


Asp Arg  Leu Lys Val Ala Pro  Gly Pro Ser Ser Gly  Ser Thr Pro 
    1355                 1360                 1365             


Gly Gln  Val Pro Gly Ser Ser  Ala Leu Ser Ser Pro  Arg Arg Ser 
    1370                 1375                 1380             


Leu Gly  Leu Ala Leu Thr His  Ser Phe Gly Pro Ser  Leu Ala Asp 
    1385                 1390                 1395             


Thr Asp  Leu Ser Pro Met Asp  Gly Ile Ser Thr Cys  Gly Pro Lys 
    1400                 1405                 1410             


Glu Glu  Val Thr Leu Arg Val  Val Val Arg Met Pro  Pro Gln His 
    1415                 1420                 1425             


Ile Ile  Lys Gly Asp Leu Lys  Gln Gln Glu Phe Phe  Leu Gly Cys 
    1430                 1435                 1440             


Ser Lys  Val Ser Gly Lys Val  Asp Trp Lys Met Leu  Asp Glu Ala 
    1445                 1450                 1455             


Val Phe  Gln Val Phe Lys Asp  Tyr Ile Ser Lys Met  Asp Pro Ala 
    1460                 1465                 1470             


Ser Thr  Leu Gly Leu Ser Thr  Glu Ser Ile His Gly  Tyr Ser Ile 
    1475                 1480                 1485             


Ser His  Val Lys Arg Val Leu  Asp Ala Glu Pro Pro  Glu Met Pro 
    1490                 1495                 1500             


Pro Cys  Arg Arg Gly Val Asn  Asn Ile Ser Val Ser  Leu Lys Gly 
    1505                 1510                 1515             


Leu Lys  Glu Lys Cys Val Asp  Ser Leu Val Phe Glu  Thr Leu Ile 
    1520                 1525                 1530             


Pro Lys  Pro Met Met Gln His  Tyr Ile Ser Leu Leu  Leu Lys His 
    1535                 1540                 1545             


Arg Arg  Leu Val Leu Ser Gly  Pro Ser Gly Thr Gly  Lys Thr Tyr 
    1550                 1555                 1560             


Leu Thr  Asn Arg Leu Ala Glu  Tyr Leu Val Glu Arg  Ser Gly Arg 
    1565                 1570                 1575             


Glu Val  Thr Glu Gly Ile Val  Ser Thr Phe Asn Met  His Gln Gln 
    1580                 1585                 1590             


Ser Cys  Lys Asp Leu Gln Leu  Tyr Leu Ser Asn Leu  Ala Asn Gln 
    1595                 1600                 1605             


Ile Asp  Arg Glu Thr Gly Ile  Gly Asp Val Pro Leu  Val Ile Leu 
    1610                 1615                 1620             


Leu Asp  Asp Leu Ser Glu Ala  Gly Ser Ile Ser Glu  Leu Val Asn 
    1625                 1630                 1635             


Gly Ala  Leu Thr Cys Lys Tyr  His Lys Cys Pro Tyr  Ile Ile Gly 
    1640                 1645                 1650             


Thr Thr  Asn Gln Pro Val Lys  Met Thr Pro Asn His  Gly Leu His 
    1655                 1660                 1665             


Leu Ser  Phe Arg Met Leu Thr  Phe Ser Asn Asn Val  Glu Pro Ala 
    1670                 1675                 1680             


Asn Gly  Phe Leu Val Arg Tyr  Leu Arg Arg Lys Leu  Val Glu Ser 
    1685                 1690                 1695             


Asp Ser  Asp Ile Asn Ala Asn  Lys Glu Glu Leu Leu  Arg Val Leu 
    1700                 1705                 1710             


Asp Trp  Val Pro Lys Leu Trp  Tyr His Leu His Thr  Phe Leu Glu 
    1715                 1720                 1725             


Lys His  Ser Thr Ser Asp Phe  Leu Ile Gly Pro Cys  Phe Phe Leu 
    1730                 1735                 1740             


Ser Cys  Pro Ile Gly Ile Glu  Asp Phe Arg Thr Trp  Phe Ile Asp 
    1745                 1750                 1755             


Leu Trp  Asn Asn Ser Ile Ile  Pro Tyr Leu Gln Glu  Gly Ala Lys 
    1760                 1765                 1770             


Asp Gly  Ile Lys Val His Gly  Gln Lys Ala Ala Trp  Glu Asp Pro 
    1775                 1780                 1785             


Val Glu  Trp Val Arg Asp Thr  Leu Pro Trp Pro Ser  Ala Gln Gln 
    1790                 1795                 1800             


Asp Gln  Ser Lys Leu Tyr His  Leu Pro Pro Pro Thr  Val Gly Pro 
    1805                 1810                 1815             


His Ser  Ile Ala Ser Pro Pro  Glu Asp Arg Thr Val  Lys Asp Ser 
    1820                 1825                 1830             


Thr Pro  Ser Ser Leu Asp Ser  Asp Pro Leu Met Ala  Met Leu Leu 
    1835                 1840                 1845             


Lys Leu  Gln Glu Ala Ala Asn  Tyr Ile Glu Ser Pro  Asp Arg Glu 
    1850                 1855                 1860             


Thr Ile  Leu Asp Pro Asn Leu  Gln Ala Thr Leu 
    1865                 1870                 


<210>  367
<211>  3126
<212>  DNA
<213>  Homosapiens

<400>  367
atggcggcgg cggcggcagc tggtgcggcc tccgggctgc cgggtccagt ggcacaagga     60

ttaaaggaag cgttagtgga tacgctcacc gggatcctat ccccagtaca ggaggtgcgg    120

gcggctgctg aagaacagat taaggtgctg gaggtgacgg aggaatttgg tgttcacttg    180

gcagaactga ctgtagatcc ccagggggca ctggcaatcc gtcagctggc atcagtcatc    240

ttgaaacaat atgtggagac tcactggtgt gcccaatcag agaaatttag gcctcctgaa    300

actacagaaa gggcaaaaat tgttatccgg gagctattgc ctaatgggtt gagagaatcg    360

ataagcaaag tgcgctccag tgtggcctat gcagtgtcag ccattgccca ctgggactgg    420

cctgaagctt ggccccaact cttcaacctg ctcatggaga tgttggtgag cggagactta    480

aatgccgtcc atggagccat gcgtgtgctg acagaattca ctcgtgaagt tacagacaca    540

cagatgccac ttgttgctcc tgtcattctc ccagagatgt ataagatctt caccatggct    600

gaggtgtatg gtattcgaac ccgttcccga gccgtggaga tttttaccac ttgtgcccat    660

atgatctgta acatggagga gctggaaaag ggtgcagcca aagtcctgat ctttcccgtg    720

gtacagcagt tcacagaggc ctttgttcag gccctccaga taccagatgg ccccacatct    780

gacagtgggt ttaagatgga ggtcctaaag gcagtgacag ccctagtgaa aaacttccca    840

aagcacatgg tgtcctccat gcagcagatt ctgcctattg tttggaacac cctaaccgag    900

agtgcagctt tttatgtgag gacagaagta aattacacag aagaagtaga agatcctgtg    960

gattctgatg gtgaagtcct gggctttgaa aatctcgtct ttagcatttt tgaatttgtc   1020

catgctctac tagaaaatag caaattcaaa agcactgtta agaaagcctt gcctgaattg   1080

atttattata ttatcctgta catgcaaatc actgaggagc agattaaagt atggacagcc   1140

aacccccaac aatttgtaga agatgaagat gatgatacat tctcctatac tgttagaata   1200

gcagctcaag acttgttgct ggctgtggcc acagatttcc agaatgaaag tgcagcagcc   1260

ctggctgctg cagccactcg acatttacaa gaagctgagc aaaccaaaaa cagtggcact   1320

gagcactggt ggaagatcca tgaggcatgc atgcttgccc taggctcagt gaaggccatc   1380

atcactgaca gtgtgaaaaa tggcaggatt cattttgaca tgcatgggtt cctgaccaat   1440

gtcatccttg cagacctcaa cctctcagtg tctcctttcc tcttgggccg ggcactttgg   1500

gctgccagtc ggttcactgt tgctatgtcc cctgaactga tccagcagtt cctacaggca   1560

acagttagtg gtcttcacga gacacagccc ccatcagttc gaatttctgc agtgagagcc   1620

atctggggtt attgtgacca actgaaagtc tcagagagta cccacgtgct ccagcccttc   1680

ctccccagca tccttgatgg cttaattcac ctagcagccc agttcagctc agaggtcctc   1740

aacctggtga tggagaccct gtgcatcgtt tgtacagtag accccgaatt cacagcaagc   1800

atggaaagca aaatctgccc cttcaccatc gccattttcc taaagtacag taatgatccc   1860

gtcgtcgcct cactggctca ggacatcttc aaggagctgt cccagattga agcctgtcag   1920

ggcccaatgc aaatgaggct gattcccact ctggtcagca taatgcaggc cccagcagac   1980

aagattcctg cagggctttg tgcgacagcc attgatatcc tgacaacagt agtacgaaat   2040

acaaagcctc ccctttccca gcttctcatc tgccaagctt tccctgctgt ggcacagtgt   2100

acccttcaca cagatgacaa tgccaccatg cagaatggcg gagagtgctt gcgggcctat   2160

gtgtcagtga ccctggaaca agtagcccag tggcatgatg agcagggcca caatggactg   2220

tggtatgtga tgcaagtggt gagccagctc ctggaccccc gcacctcaga gttcactgcg   2280

gcctttgtgg gccgccttgt ttccaccctc atctccaagg cagggcggga actcggggag   2340

aatctagacc agattcttcg tgccatcctc agtaagatgc agcaggcaga gacgctcagt   2400

gtcatgcagt ccctgatcat ggtgttcgct catctggtgc acactcagct agaacctctc   2460

ttggagttcc tgtgtagcct cccaggacct actggcaaac ctgctctaga gtttgtgatg   2520

gctgagtgga caagccgaca gcacctgttc tatggacagt atgaaggcaa agtcagctct   2580

gtggcactct gtaagctgct ccagcatggc atcaatgcag atgacaaacg gctacaggat   2640

atccgtgtga agggagagga gatctacagc atggatgagg gcatccgcac ccgctctaag   2700

tcagccaaaa acccagaacg ctggacaaac attcctttgc tggtcaagat cctaaagctg   2760

atcatcaacg agctctccaa cgtcatggag gctaatgccg ctcgccaggc cactcctgca   2820

gagtggagtc aagatgactc caatgatatg tgggaggacc aggaggagga agaggaggag   2880

gaggaggatg gtttagctgg ccaactttta tctgacattc ttgctacaag taaatatgag   2940

gaggattact acgaggatga tgaggaagat gaccctgatg ccctgaagga tcctctctat   3000

cagattgatc tgcaggcata tctcacagat ttcctctgcc agtttgctca gcagccctgc   3060

tacataatgt tttcaggcca ccttaatgac aatgagaggc gagttctaca gaccatcggc   3120

atctaa                                                              3126


<210>  368
<211>  1041
<212>  PRT
<213>  Homosapiens

<400>  368

Met Ala Ala Ala Ala Ala Ala Gly Ala Ala Ser Gly Leu Pro Gly Pro 
1               5                   10                  15      


Val Ala Gln Gly Leu Lys Glu Ala Leu Val Asp Thr Leu Thr Gly Ile 
            20                  25                  30          


Leu Ser Pro Val Gln Glu Val Arg Ala Ala Ala Glu Glu Gln Ile Lys 
        35                  40                  45              


Val Leu Glu Val Thr Glu Glu Phe Gly Val His Leu Ala Glu Leu Thr 
    50                  55                  60                  


Val Asp Pro Gln Gly Ala Leu Ala Ile Arg Gln Leu Ala Ser Val Ile 
65                  70                  75                  80  


Leu Lys Gln Tyr Val Glu Thr His Trp Cys Ala Gln Ser Glu Lys Phe 
                85                  90                  95      


Arg Pro Pro Glu Thr Thr Glu Arg Ala Lys Ile Val Ile Arg Glu Leu 
            100                 105                 110         


Leu Pro Asn Gly Leu Arg Glu Ser Ile Ser Lys Val Arg Ser Ser Val 
        115                 120                 125             


Ala Tyr Ala Val Ser Ala Ile Ala His Trp Asp Trp Pro Glu Ala Trp 
    130                 135                 140                 


Pro Gln Leu Phe Asn Leu Leu Met Glu Met Leu Val Ser Gly Asp Leu 
145                 150                 155                 160 


Asn Ala Val His Gly Ala Met Arg Val Leu Thr Glu Phe Thr Arg Glu 
                165                 170                 175     


Val Thr Asp Thr Gln Met Pro Leu Val Ala Pro Val Ile Leu Pro Glu 
            180                 185                 190         


Met Tyr Lys Ile Phe Thr Met Ala Glu Val Tyr Gly Ile Arg Thr Arg 
        195                 200                 205             


Ser Arg Ala Val Glu Ile Phe Thr Thr Cys Ala His Met Ile Cys Asn 
    210                 215                 220                 


Met Glu Glu Leu Glu Lys Gly Ala Ala Lys Val Leu Ile Phe Pro Val 
225                 230                 235                 240 


Val Gln Gln Phe Thr Glu Ala Phe Val Gln Ala Leu Gln Ile Pro Asp 
                245                 250                 255     


Gly Pro Thr Ser Asp Ser Gly Phe Lys Met Glu Val Leu Lys Ala Val 
            260                 265                 270         


Thr Ala Leu Val Lys Asn Phe Pro Lys His Met Val Ser Ser Met Gln 
        275                 280                 285             


Gln Ile Leu Pro Ile Val Trp Asn Thr Leu Thr Glu Ser Ala Ala Phe 
    290                 295                 300                 


Tyr Val Arg Thr Glu Val Asn Tyr Thr Glu Glu Val Glu Asp Pro Val 
305                 310                 315                 320 


Asp Ser Asp Gly Glu Val Leu Gly Phe Glu Asn Leu Val Phe Ser Ile 
                325                 330                 335     


Phe Glu Phe Val His Ala Leu Leu Glu Asn Ser Lys Phe Lys Ser Thr 
            340                 345                 350         


Val Lys Lys Ala Leu Pro Glu Leu Ile Tyr Tyr Ile Ile Leu Tyr Met 
        355                 360                 365             


Gln Ile Thr Glu Glu Gln Ile Lys Val Trp Thr Ala Asn Pro Gln Gln 
    370                 375                 380                 


Phe Val Glu Asp Glu Asp Asp Asp Thr Phe Ser Tyr Thr Val Arg Ile 
385                 390                 395                 400 


Ala Ala Gln Asp Leu Leu Leu Ala Val Ala Thr Asp Phe Gln Asn Glu 
                405                 410                 415     


Ser Ala Ala Ala Leu Ala Ala Ala Ala Thr Arg His Leu Gln Glu Ala 
            420                 425                 430         


Glu Gln Thr Lys Asn Ser Gly Thr Glu His Trp Trp Lys Ile His Glu 
        435                 440                 445             


Ala Cys Met Leu Ala Leu Gly Ser Val Lys Ala Ile Ile Thr Asp Ser 
    450                 455                 460                 


Val Lys Asn Gly Arg Ile His Phe Asp Met His Gly Phe Leu Thr Asn 
465                 470                 475                 480 


Val Ile Leu Ala Asp Leu Asn Leu Ser Val Ser Pro Phe Leu Leu Gly 
                485                 490                 495     


Arg Ala Leu Trp Ala Ala Ser Arg Phe Thr Val Ala Met Ser Pro Glu 
            500                 505                 510         


Leu Ile Gln Gln Phe Leu Gln Ala Thr Val Ser Gly Leu His Glu Thr 
        515                 520                 525             


Gln Pro Pro Ser Val Arg Ile Ser Ala Val Arg Ala Ile Trp Gly Tyr 
    530                 535                 540                 


Cys Asp Gln Leu Lys Val Ser Glu Ser Thr His Val Leu Gln Pro Phe 
545                 550                 555                 560 


Leu Pro Ser Ile Leu Asp Gly Leu Ile His Leu Ala Ala Gln Phe Ser 
                565                 570                 575     


Ser Glu Val Leu Asn Leu Val Met Glu Thr Leu Cys Ile Val Cys Thr 
            580                 585                 590         


Val Asp Pro Glu Phe Thr Ala Ser Met Glu Ser Lys Ile Cys Pro Phe 
        595                 600                 605             


Thr Ile Ala Ile Phe Leu Lys Tyr Ser Asn Asp Pro Val Val Ala Ser 
    610                 615                 620                 


Leu Ala Gln Asp Ile Phe Lys Glu Leu Ser Gln Ile Glu Ala Cys Gln 
625                 630                 635                 640 


Gly Pro Met Gln Met Arg Leu Ile Pro Thr Leu Val Ser Ile Met Gln 
                645                 650                 655     


Ala Pro Ala Asp Lys Ile Pro Ala Gly Leu Cys Ala Thr Ala Ile Asp 
            660                 665                 670         


Ile Leu Thr Thr Val Val Arg Asn Thr Lys Pro Pro Leu Ser Gln Leu 
        675                 680                 685             


Leu Ile Cys Gln Ala Phe Pro Ala Val Ala Gln Cys Thr Leu His Thr 
    690                 695                 700                 


Asp Asp Asn Ala Thr Met Gln Asn Gly Gly Glu Cys Leu Arg Ala Tyr 
705                 710                 715                 720 


Val Ser Val Thr Leu Glu Gln Val Ala Gln Trp His Asp Glu Gln Gly 
                725                 730                 735     


His Asn Gly Leu Trp Tyr Val Met Gln Val Val Ser Gln Leu Leu Asp 
            740                 745                 750         


Pro Arg Thr Ser Glu Phe Thr Ala Ala Phe Val Gly Arg Leu Val Ser 
        755                 760                 765             


Thr Leu Ile Ser Lys Ala Gly Arg Glu Leu Gly Glu Asn Leu Asp Gln 
    770                 775                 780                 


Ile Leu Arg Ala Ile Leu Ser Lys Met Gln Gln Ala Glu Thr Leu Ser 
785                 790                 795                 800 


Val Met Gln Ser Leu Ile Met Val Phe Ala His Leu Val His Thr Gln 
                805                 810                 815     


Leu Glu Pro Leu Leu Glu Phe Leu Cys Ser Leu Pro Gly Pro Thr Gly 
            820                 825                 830         


Lys Pro Ala Leu Glu Phe Val Met Ala Glu Trp Thr Ser Arg Gln His 
        835                 840                 845             


Leu Phe Tyr Gly Gln Tyr Glu Gly Lys Val Ser Ser Val Ala Leu Cys 
    850                 855                 860                 


Lys Leu Leu Gln His Gly Ile Asn Ala Asp Asp Lys Arg Leu Gln Asp 
865                 870                 875                 880 


Ile Arg Val Lys Gly Glu Glu Ile Tyr Ser Met Asp Glu Gly Ile Arg 
                885                 890                 895     


Thr Arg Ser Lys Ser Ala Lys Asn Pro Glu Arg Trp Thr Asn Ile Pro 
            900                 905                 910         


Leu Leu Val Lys Ile Leu Lys Leu Ile Ile Asn Glu Leu Ser Asn Val 
        915                 920                 925             


Met Glu Ala Asn Ala Ala Arg Gln Ala Thr Pro Ala Glu Trp Ser Gln 
    930                 935                 940                 


Asp Asp Ser Asn Asp Met Trp Glu Asp Gln Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Glu Asp Gly Leu Ala Gly Gln Leu Leu Ser Asp Ile Leu Ala Thr 
                965                 970                 975     


Ser Lys Tyr Glu Glu Asp Tyr Tyr Glu Asp Asp Glu Glu Asp Asp Pro 
            980                 985                 990         


Asp Ala Leu Lys Asp Pro Leu Tyr  Gln Ile Asp Leu Gln  Ala Tyr Leu 
        995                 1000                 1005             


Thr Asp  Phe Leu Cys Gln Phe  Ala Gln Gln Pro Cys  Tyr Ile Met 
    1010                 1015                 1020             


Phe Ser  Gly His Leu Asn Asp  Asn Glu Arg Arg Val  Leu Gln Thr 
    1025                 1030                 1035             


Ile Gly  Ile 
    1040     


<210>  369
<211>  1141
<212>  DNA
<213>  Homosapiens

<400>  369
gggctgggcc ccgccgcagc tccagctggc cggcttggtc ctgcggtccc ttctctggga     60

ggcccgaccc cggccgcgcc cagcccccac catgccaccc gcggggctcc gccgggccgc    120

gccgctcacc gcaatcgctc tgttggtgct gggggctccc ctggtgctgg ccggcgagga    180

ctgcctgtgg tacctggacc ggaatggctc ctggcatccg gggtttaact gcgagttctt    240

caccttctgc tgcgggacct gctaccatcg gtactgctgc agggacctga ccttgcttat    300

caccgagagg cagcagaagc actgcctggc cttcagcccc aagaccatag caggcatcgc    360

ctcagctgtg atcctctttg ttgctgtggt tgccaccacc atctgctgct tcctctgttc    420

ctgttgctac ctgtaccgcc ggcgccagca gctccagagc ccatttgaag gccaggagat    480

tccaatgaca ggcatcccag tgcagccagt atacccatac ccccaggacc ccaaagctgg    540

ccctgcaccc ccacagcctg gcttcatgta cccacctagt ggtcctgctc cccaatatcc    600

actctaccca gctgggcccc cagtctacaa ccctgcagct cctcctccct atatgccacc    660

acagccctct tacccgggag cctgaggaac cagccatgtc tctgctgccc cttcagtgat    720

gccaaccttg ggagatgccc tcatcctgta cctgcatctg gtcctggggg tggcaggagt    780

cctccagcca ccaggcccca gaccaagcca agccctgggc cctactgggg acagagcccc    840

agggaagtgg aacaggagct gaactagaac tatgaggggt tggggggagg gcttggaatt    900

atgggctatt tttactgggg gcaagggagg gagatgacag cctgggtcac agtgcctgtt    960

ttcaaatagt ccctctgctc ccaagatccc agccaggaag gctggggccc tactgtttgt   1020

cccctctggg ctggggtggg gggagggagg aggttccgtc agcagctggc agtagccctc   1080

ctctctggct gccccactgg ccacatctct ggcctgctag attaaagctg taaagacaaa   1140

a                                                                   1141


<210>  370
<211>  197
<212>  PRT
<213>  Homosapiens

<400>  370

Met Pro Pro Ala Gly Leu Arg Arg Ala Ala Pro Leu Thr Ala Ile Ala 
1               5                   10                  15      


Leu Leu Val Leu Gly Ala Pro Leu Val Leu Ala Gly Glu Asp Cys Leu 
            20                  25                  30          


Trp Tyr Leu Asp Arg Asn Gly Ser Trp His Pro Gly Phe Asn Cys Glu 
        35                  40                  45              


Phe Phe Thr Phe Cys Cys Gly Thr Cys Tyr His Arg Tyr Cys Cys Arg 
    50                  55                  60                  


Asp Leu Thr Leu Leu Ile Thr Glu Arg Gln Gln Lys His Cys Leu Ala 
65                  70                  75                  80  


Phe Ser Pro Lys Thr Ile Ala Gly Ile Ala Ser Ala Val Ile Leu Phe 
                85                  90                  95      


Val Ala Val Val Ala Thr Thr Ile Cys Cys Phe Leu Cys Ser Cys Cys 
            100                 105                 110         


Tyr Leu Tyr Arg Arg Arg Gln Gln Leu Gln Ser Pro Phe Glu Gly Gln 
        115                 120                 125             


Glu Ile Pro Met Thr Gly Ile Pro Val Gln Pro Val Tyr Pro Tyr Pro 
    130                 135                 140                 


Gln Asp Pro Lys Ala Gly Pro Ala Pro Pro Gln Pro Gly Phe Met Tyr 
145                 150                 155                 160 


Pro Pro Ser Gly Pro Ala Pro Gln Tyr Pro Leu Tyr Pro Ala Gly Pro 
                165                 170                 175     


Pro Val Tyr Asn Pro Ala Ala Pro Pro Pro Tyr Met Pro Pro Gln Pro 
            180                 185                 190         


Ser Tyr Pro Gly Ala 
        195         


<210>  371
<211>  3881
<212>  DNA
<213>  Homosapiens

<400>  371
gctgaagtgt tcgaccagca ggaggttttc tcctcagccc actcgctgca tccagatcag     60

ctcaccccgc gccctttcct gcccaccagg actctgatag cccctggcag ccacagccca    120

ttttgccaag atgtctagag tagccaaata tcgccggcag tgagtgaaga ccccgacatc    180

gacagcctgc tgggaccctg tctcccgagg agatggagga gctggagaag gagctggacg    240

tggtggaccc agacgggagt gttcccgtgg ggctgcggca gagaaaccag acggagaaac    300

agtccacggg tgtgtacaac cgggaggcca tgctcaactt ctgtgaaaag gagaccaaga    360

aacttatgca gagggagatg tccatggatg aaagcaagca agtggagacc aagacagatg    420

ccaagaatgg acaggaaagg ggcagagatg ccagcaaaaa agccctgggc cccagacgga    480

actcagatct ggggaaggag ccaaagaggg gtggtttaaa gaaaagcttc tctagagaca    540

gagatgaagc tggtggcaag agtggcgaga agcccaagga ggagaagatc atccggggca    600

ttgacaaggg ccgggtcagg gctgcagtgg ataagaagga ggcagggaag gatgggagag    660

gagaggagag ggcagtggcc accaagaagg aagaggagaa gaaagggggt gacaggaaca    720

caggcttgag cagggacaag gataaaaaga gagaggagat gaaggaggtg gccaagaaag    780

aggatgatga gaaggtaaaa ggggagcgta ggaacacaga caccagaaaa gagggtgaga    840

agatgaaaag agcaggtggg aacacagaca tgaaaaagga ggatgagaag gtaaaaagag    900

gaactgggaa cacagacacc aaaaaggacg atgaaaaagt caagaagaat gaacccttac    960

atgaaaagga agccaaggat gacagcaaga ccaaaacacc cgagaaacag acgcccagtg   1020

gccccaccaa gccctctgaa ggaccggcca aggtggagga ggaggcagct cccagcatat   1080

ttgatgagcc tctggagaga gtgaagaaca atgaccccga gatgactgag gtgaacgtca   1140

acaactcaga ctgcatcaca aatgagatct tggtccggtt tactgaggct ctggagttca   1200

acactgtggt taagctgttc gccttggcca acacgcgagc cgatgaccac gtggcctttg   1260

ccattgccat catgctcaag gccaacaaga ccatcaccag cctcaacctg gactccaacc   1320

acatcacagg caaaggcatc ctggccatct tccgggccct cctccagaac aacacgctga   1380

ccgagctccg cttccacaac cagcgacaca tctgtggagg caagacggag atggagatcg   1440

ccaagctgct gaaggagaat acctccctgc tcaagctggg ctaccatttt gagctggccg   1500

ggccccgaat gactgtcacc aatctgctca gccgcaacat ggacaagcag agacaaaagc   1560

ggctgcagga gcaaaggcag gcacaggaag ccaagggaga gaagaaggat ctgctggagg   1620

tacccaaggc cggggccgtg gctaagggct ccccaaaacc ttcacctcaa ccatctccaa   1680

agccctctcc aaagaactca cccaaaaaag ggggtgctcc agctgcccca ccaccccctc   1740

cccctccctt ggctccaccc cttatcatgg agaacctgaa gaattcactc tcaccagcta   1800

cccagaggaa gatgggagac aaagtcctcc ctgcccagga gaagaactcc cgtgaccagc   1860

tattggctgc catccgctcc agcaacctca agcagctcaa gaaggtggaa gtgcccaaac   1920

tgcttcagta ggaccaggct gccaggcacc atctgccaat gccatgactg ctcaggcctc   1980

acctcccagg gctacacaga ccctgcccac cccatccctg gctgacctgc tgtggatgtc   2040

cctattctgc catgggagcg tccaggcctg ggtcacgctc aaggaaggat gccttatctc   2100

ttctcacttt ccttttcttg tctctgaggc tctccaaatt ttgctttagt acatggagct   2160

caggtttctg gacaagaaga gtccttttag cacatcactg agaagatggc actgtccagg   2220

gcccatgtag ctggcaagct gcaaaaggcc tgtgatccag gaaagatgtc ccacagggac   2280

cacatccacc ccagccccac tgccctccag ggccaggatt caggcctctg aggagcccac   2340

ggggcaaagc tgctgggcca gtggcactct gtgtgggaaa atggcagaaa gatggagagg   2400

catgggggcc caaaggggag cgtggggagg ggctgaggat accccaaagt ccaggctaat   2460

tagaggatgt ggcaggggca gtggcctgga tgcacagtgc ctgatgggag taggctccag   2520

acaggaggag tgggacagac agcagctgga cttgaaggtt tgatgccaaa gcagacattt   2580

tcctcacacc cacctgctgc tgtatgaata gctgtgtatc tgtttttcca taagattttg   2640

ataatatata caaaccttta gctgtgaatg gctgtgcccc acctgttgtc ctgaactgtg   2700

agtcctgatc ctaaccctgg gctccctgga ggactctaga agctcaggtt ccctgccaca   2760

ctatttgagt tggccaagaa ataaattcac atcctcagaa agtgcagcat ggaggaaaat   2820

ctgaactcta agcagaagac tctccactga cctggttgtc caggtctaga aggccaggcc   2880

tctactaggt ctgctcctga accagtcctg ctgcctggag tcagtagcca gagttgttct   2940

caggggtgct ggggcagagt ggagcccagg gtgctgggat ggctatatta ggcatgttca   3000

gggatgctca ttccatgact ctgcctaacc atgggctcag ggccaggtcc tcacagcagt   3060

cacaggccca ggaaggcggc aggcagagaa gtggagtgac tatttggaga atagcaccca   3120

tatctgtgtg ccctagggct cagaggggcc tcatcttccc cagccctccc cacctgctca   3180

ccaattccac ttcctgcccc aactgcagga atgctgacaa tgctgccatg cccaccatcg   3240

ggtgtaggtg aaaggcatct ttctgaattt cattctcttg aaggtgctgc caccccttgg   3300

cactgtggaa ctgccacctt gggtctgtgt cacttgtagg tttctctgcc tccaggttgc   3360

ctcaacagca ggaggcacag cagtttcacc atctttgagg tgagggtggg gtgccccagc   3420

taggaagcaa gatcgctgtg ctaggtctga ccaaaaccag agggcagtct agtcctgggg   3480

gtaaagccct cagatcccag ggtacactct tctccattcc ctccacccac ttgcctgtca   3540

ccccagtcac ctaagcaatc actgggccca gaggagagga gacagacaca cactggctcc   3600

tggacctaaa gggtatgagc tggagctaag gccagctaga gcttccactg tcagccctca   3660

ctgtcagccc cactgcaccc ccctgtgcct gctgggcact gggcactagc tagatgcttt   3720

aggttgcttc agctgatcct tcaactctgt gaggtggata ccaatattct attttgcaga   3780

tagaatttgg cccagagagg ttaactaata tatccatgat cacacagcta ataaaagtca   3840

gagctcagga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       3881


<210>  372
<211>  572
<212>  PRT
<213>  Homosapiens

<400>  372

Met Glu Glu Leu Glu Lys Glu Leu Asp Val Val Asp Pro Asp Gly Ser 
1               5                   10                  15      


Val Pro Val Gly Leu Arg Gln Arg Asn Gln Thr Glu Lys Gln Ser Thr 
            20                  25                  30          


Gly Val Tyr Asn Arg Glu Ala Met Leu Asn Phe Cys Glu Lys Glu Thr 
        35                  40                  45              


Lys Lys Leu Met Gln Arg Glu Met Ser Met Asp Glu Ser Lys Gln Val 
    50                  55                  60                  


Glu Thr Lys Thr Asp Ala Lys Asn Gly Gln Glu Arg Gly Arg Asp Ala 
65                  70                  75                  80  


Ser Lys Lys Ala Leu Gly Pro Arg Arg Asn Ser Asp Leu Gly Lys Glu 
                85                  90                  95      


Pro Lys Arg Gly Gly Leu Lys Lys Ser Phe Ser Arg Asp Arg Asp Glu 
            100                 105                 110         


Ala Gly Gly Lys Ser Gly Glu Lys Pro Lys Glu Glu Lys Ile Ile Arg 
        115                 120                 125             


Gly Ile Asp Lys Gly Arg Val Arg Ala Ala Val Asp Lys Lys Glu Ala 
    130                 135                 140                 


Gly Lys Asp Gly Arg Gly Glu Glu Arg Ala Val Ala Thr Lys Lys Glu 
145                 150                 155                 160 


Glu Glu Lys Lys Gly Gly Asp Arg Asn Thr Gly Leu Ser Arg Asp Lys 
                165                 170                 175     


Asp Lys Lys Arg Glu Glu Met Lys Glu Val Ala Lys Lys Glu Asp Asp 
            180                 185                 190         


Glu Lys Val Lys Gly Glu Arg Arg Asn Thr Asp Thr Arg Lys Glu Gly 
        195                 200                 205             


Glu Lys Met Lys Arg Ala Gly Gly Asn Thr Asp Met Lys Lys Glu Asp 
    210                 215                 220                 


Glu Lys Val Lys Arg Gly Thr Gly Asn Thr Asp Thr Lys Lys Asp Asp 
225                 230                 235                 240 


Glu Lys Val Lys Lys Asn Glu Pro Leu His Glu Lys Glu Ala Lys Asp 
                245                 250                 255     


Asp Ser Lys Thr Lys Thr Pro Glu Lys Gln Thr Pro Ser Gly Pro Thr 
            260                 265                 270         


Lys Pro Ser Glu Gly Pro Ala Lys Val Glu Glu Glu Ala Ala Pro Ser 
        275                 280                 285             


Ile Phe Asp Glu Pro Leu Glu Arg Val Lys Asn Asn Asp Pro Glu Met 
    290                 295                 300                 


Thr Glu Val Asn Val Asn Asn Ser Asp Cys Ile Thr Asn Glu Ile Leu 
305                 310                 315                 320 


Val Arg Phe Thr Glu Ala Leu Glu Phe Asn Thr Val Val Lys Leu Phe 
                325                 330                 335     


Ala Leu Ala Asn Thr Arg Ala Asp Asp His Val Ala Phe Ala Ile Ala 
            340                 345                 350         


Ile Met Leu Lys Ala Asn Lys Thr Ile Thr Ser Leu Asn Leu Asp Ser 
        355                 360                 365             


Asn His Ile Thr Gly Lys Gly Ile Leu Ala Ile Phe Arg Ala Leu Leu 
    370                 375                 380                 


Gln Asn Asn Thr Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Ile 
385                 390                 395                 400 


Cys Gly Gly Lys Thr Glu Met Glu Ile Ala Lys Leu Leu Lys Glu Asn 
                405                 410                 415     


Thr Ser Leu Leu Lys Leu Gly Tyr His Phe Glu Leu Ala Gly Pro Arg 
            420                 425                 430         


Met Thr Val Thr Asn Leu Leu Ser Arg Asn Met Asp Lys Gln Arg Gln 
        435                 440                 445             


Lys Arg Leu Gln Glu Gln Arg Gln Ala Gln Glu Ala Lys Gly Glu Lys 
    450                 455                 460                 


Lys Asp Leu Leu Glu Val Pro Lys Ala Gly Ala Val Ala Lys Gly Ser 
465                 470                 475                 480 


Pro Lys Pro Ser Pro Gln Pro Ser Pro Lys Pro Ser Pro Lys Asn Ser 
                485                 490                 495     


Pro Lys Lys Gly Gly Ala Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro 
            500                 505                 510         


Leu Ala Pro Pro Leu Ile Met Glu Asn Leu Lys Asn Ser Leu Ser Pro 
        515                 520                 525             


Ala Thr Gln Arg Lys Met Gly Asp Lys Val Leu Pro Ala Gln Glu Lys 
    530                 535                 540                 


Asn Ser Arg Asp Gln Leu Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys 
545                 550                 555                 560 


Gln Leu Lys Lys Val Glu Val Pro Lys Leu Leu Gln 
                565                 570         


<210>  373
<211>  1645
<212>  DNA
<213>  Homosapiens

<400>  373
agtcaagatg gaggagtacg cgcgagagcc ttgcccatgg cgaattgtgg atgactgtgg     60

tggggccttt acgatgggta ccattggtgg tggtatcttt caagcaatca aaggttttcg    120

caattctcca gtgggagtaa accacagact acgagggagt ttgacagcta ttaaaaccag    180

ggctccacag ttaggaggta gctttgcagt ttggggaggg ctgttttcca tgattgactg    240

tagtatggtt caagtcagag gaaaggaaga tccctggaac tccatcacaa gtggtgcctt    300

aacgggagcc atactggcag caagaaatgg accagtggcc atggttgggt cagccgcaat    360

gggtggcatt ctcctagctt taattgaagg agctggtatc ttgttgacaa gatttgcctc    420

tgcacagttt cccaatggtc ctcagtttgc agaagacccc tcccagttgc cttcaactca    480

gttaccttcc tcaccttttg gagactatcg acaatatcag taggacttct ttcctaggat    540

ttctttaaca gaacgagttg tggttcgaga aggatttcag aagatcaagt tacagtctgt    600

ttttaaaacc ataggtggga cagctatggc caataggcta taaagagaca tttagcactt    660

ttttctattt aaaggaacaa gcggggaagg gtgctaaaag ataatacgtt tatttattca    720

cacttgaatt gcatttgtga tcaaaataaa tgtttaaatc gctaaaggaa aatacagtaa    780

gtgcttgaaa gatgaaggac caaaaggcca aaaaacagtg aaatatgatc atcatctctt    840

gcggacttct ctgcctggtt ttgtgtgttc tgttattcaa acaataaaaa gctggtggaa    900

cttactcttt cttttaagat aagttgtaga cttcgatgtt tcatgctcat gtacttcaaa    960

taatgcatgt tttatagtta gtccctcatc acttgaagtg acttctgaga attatgcaga   1020

gtcaacatgg atcatttcac agtgagatgc tttatggatt gaaggatatg gtaaaatgtt   1080

tatagtttac tttgaaagta aaatatacta tgtcttggtt ttgaggatat tggatacaaa   1140

actctcttcc tttagggcta ctgagtcttg attcctgatc atcagaaatt tcaccagaaa   1200

caacttgctt ccaatatacc caattctata tgaagaattc atggagagtg tactggcact   1260

ggaagagttt agtgtttctt gtatgcttga aaataaagta tgtactgttt tgaatgtgtt   1320

ccaagtcctc tgcataaacg atgtattttg gggtctggtt gggcctggaa aatggatgag   1380

cacttcagaa caggtcattt tcctgatatt ggaagtgaca tgtggcccta taggaggcat   1440

gatgttagtt aattacacat ttgcctacat ctgtgggaaa tggagaacaa agccatgtgg   1500

gtactgtaaa cacacgttta tcttttggcc caatgccata catatggtag gcatttaatt   1560

actgattgtg tttggataat ttgggaattt tcgactgtgg taaaatatac ataaaataat   1620

acttattaaa aaaaaaaaaa aaaaa                                         1645


<210>  374
<211>  171
<212>  PRT
<213>  Homosapiens

<400>  374

Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val Asp Asp 
1               5                   10                  15      


Cys Gly Gly Ala Phe Thr Met Gly Thr Ile Gly Gly Gly Ile Phe Gln 
            20                  25                  30          


Ala Ile Lys Gly Phe Arg Asn Ser Pro Val Gly Val Asn His Arg Leu 
        35                  40                  45              


Arg Gly Ser Leu Thr Ala Ile Lys Thr Arg Ala Pro Gln Leu Gly Gly 
    50                  55                  60                  


Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Met Ile Asp Cys Ser Met 
65                  70                  75                  80  


Val Gln Val Arg Gly Lys Glu Asp Pro Trp Asn Ser Ile Thr Ser Gly 
                85                  90                  95      


Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg Asn Gly Pro Val Ala Met 
            100                 105                 110         


Val Gly Ser Ala Ala Met Gly Gly Ile Leu Leu Ala Leu Ile Glu Gly 
        115                 120                 125             


Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser Ala Gln Phe Pro Asn Gly 
    130                 135                 140                 


Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu Pro Ser Thr Gln Leu Pro 
145                 150                 155                 160 


Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr Gln 
                165                 170     


<210>  375
<211>  2430
<212>  DNA
<213>  Homosapiens

<400>  375
cccggccggt gagcaacggc tctgcggcca tggcgagcgg cgagcattcc cccggcagcg     60

gcgcggcccg gcggccgctg cactccgcgc aggctgtgga cgtggcctcg gcctccaact    120

tccgggcctt tgagctgctg cacttgcacc tggacctgcg ggctgagttc gggcctccag    180

ggcccggcgc agggagccgg gggctgagcg gcaccgcggt cctggacctg cgctgcctgg    240

agcccgaggg cgccgccgag ctgcggctgg actcgcaccc gtgcctggag gtgacggcgg    300

cggcgctgcg gcgggagcgg cccggctcgg aggagccgcc tgcggagccc gtgagcttct    360

acacgcagcc cttctcgcac tatggccagg ccctgtgcgt gtccttcccg cagccctgcc    420

gcgccgccga gcgcctccag gtgctgctca cctaccgcgt cggggaggga cccggggttt    480

gctggttggc tcccgagcag acagcaggaa agaagaagcc cttcgtgtac acccagggcc    540

aggctgtcct aaaccgggcc ttcttccctt gcttcgacac gcctgctgtt aaatacaagt    600

attcagctct tattgaggtc ccagatggct tcacagctgt gatgagtgct agcacctggg    660

agaagagagg tccaaataag ttcttcttcc agatgtgtca gcccatcccc tcctatctga    720

tagctttggc catcggagat ctggtttcgg ctgaagttgg acccaggagc cgggtgtggg    780

ctgagccctg cctgattgat gctgccaagg aggagtacaa cggggtgata gaagaatttt    840

tggcaacagg agagaagctt tttggacctt atgtttgggg aaggtatgac ttgctcttca    900

tgccaccgtc ctttccattt ggaggaatgg agaacccttg tctgaccttt gtcaccccct    960

gcctgctagc tggggaccgc tccttggcag atgtcatcat ccatgagatc tcccacagtt   1020

ggtttgggaa cctggtcacc aacgccaact ggggtgaatt ctggctcaat gaaggtttca   1080

ccatgtacgc ccagaggagg atctccacca tcctctttgg cgctgcgtac acctgcttgg   1140

aggctgcaac ggggcgggct ctgctgcgtc agcacatgga catcactgga gaggaaaacc   1200

cactcaacaa gctccgcgtg aagattgaac caggcgttga cccggacgac acctataatg   1260

agacccccta cgagaaaggt ttctgctttg tctcatacct ggcccacttg gtgggtgatc   1320

aggatcagtt tgacagtttt ctcaaggcct atgtgcatga attcaaattc cgaagcatct   1380

tagccgatga ctttctggac ttctacttgg aatatttccc tgagcttaag aaaaagagag   1440

tggatatcat tccaggtttt gagtttgatc gatggctgaa tacccccggc tggcccccgt   1500

acctccctga tctctcccct ggggactcac tcatgaagcc tgctgaagag ctagcccaac   1560

tgtgggcagc cgaggagctg gacatgaagg ccattgaagc cgtggccatc tctccctgga   1620

agacctacca gctggtctac ttcctggata agatcctcca gaaatcccct ctccctcctg   1680

ggaatgtgaa aaaacttgga gacacatacc caagtatctc aaatgcccgg aatgcagagc   1740

tccggctgcg atggggccaa atcgtcctta agaacgacca ccaggaagat ttctggaaag   1800

tgaaggagtt cctgcataac caggggaagc agaagtatac acttccgctg taccacgcaa   1860

tgatgggtgg cagtgaggtg gcccagaccc tcgccaagga gacttttgca tccaccgcct   1920

cccagctcca cagcaatgtt gtcaactatg tccagcagat cgtggcaccc aagggcagtt   1980

agaggctcgt gtgcatggcc cctgcctctt caggctctcc aggctttcag aataattgtt   2040

tgttcccaaa ttcctgttcc ctgatcaact tcctggagtt tatatcccct caggataatc   2100

tattctctag cttaggtatc tgtgactctt gggcctctgc tctggtggga acttacttct   2160

ctatagccca ctgagccccg agacagagaa cctgcccaca gctctccccg ctacaggctg   2220

caggcactgc agggcagcgg gtattctcct ccccacctaa gtctctggga agaagtggag   2280

aggactgatg ctcttctttt ttctctttct gtcctttttc ttgctgattt tatgcaaagg   2340

gctggcattc tgattgttct tttttcaggt ttaatcctta ttttaataaa gttttcaagc   2400

aaaaattaag ttaaaaaaaa aaaaaaaaaa                                    2430


<210>  376
<211>  650
<212>  PRT
<213>  Homosapiens

<400>  376

Met Ala Ser Gly Glu His Ser Pro Gly Ser Gly Ala Ala Arg Arg Pro 
1               5                   10                  15      


Leu His Ser Ala Gln Ala Val Asp Val Ala Ser Ala Ser Asn Phe Arg 
            20                  25                  30          


Ala Phe Glu Leu Leu His Leu His Leu Asp Leu Arg Ala Glu Phe Gly 
        35                  40                  45              


Pro Pro Gly Pro Gly Ala Gly Ser Arg Gly Leu Ser Gly Thr Ala Val 
    50                  55                  60                  


Leu Asp Leu Arg Cys Leu Glu Pro Glu Gly Ala Ala Glu Leu Arg Leu 
65                  70                  75                  80  


Asp Ser His Pro Cys Leu Glu Val Thr Ala Ala Ala Leu Arg Arg Glu 
                85                  90                  95      


Arg Pro Gly Ser Glu Glu Pro Pro Ala Glu Pro Val Ser Phe Tyr Thr 
            100                 105                 110         


Gln Pro Phe Ser His Tyr Gly Gln Ala Leu Cys Val Ser Phe Pro Gln 
        115                 120                 125             


Pro Cys Arg Ala Ala Glu Arg Leu Gln Val Leu Leu Thr Tyr Arg Val 
    130                 135                 140                 


Gly Glu Gly Pro Gly Val Cys Trp Leu Ala Pro Glu Gln Thr Ala Gly 
145                 150                 155                 160 


Lys Lys Lys Pro Phe Val Tyr Thr Gln Gly Gln Ala Val Leu Asn Arg 
                165                 170                 175     


Ala Phe Phe Pro Cys Phe Asp Thr Pro Ala Val Lys Tyr Lys Tyr Ser 
            180                 185                 190         


Ala Leu Ile Glu Val Pro Asp Gly Phe Thr Ala Val Met Ser Ala Ser 
        195                 200                 205             


Thr Trp Glu Lys Arg Gly Pro Asn Lys Phe Phe Phe Gln Met Cys Gln 
    210                 215                 220                 


Pro Ile Pro Ser Tyr Leu Ile Ala Leu Ala Ile Gly Asp Leu Val Ser 
225                 230                 235                 240 


Ala Glu Val Gly Pro Arg Ser Arg Val Trp Ala Glu Pro Cys Leu Ile 
                245                 250                 255     


Asp Ala Ala Lys Glu Glu Tyr Asn Gly Val Ile Glu Glu Phe Leu Ala 
            260                 265                 270         


Thr Gly Glu Lys Leu Phe Gly Pro Tyr Val Trp Gly Arg Tyr Asp Leu 
        275                 280                 285             


Leu Phe Met Pro Pro Ser Phe Pro Phe Gly Gly Met Glu Asn Pro Cys 
    290                 295                 300                 


Leu Thr Phe Val Thr Pro Cys Leu Leu Ala Gly Asp Arg Ser Leu Ala 
305                 310                 315                 320 


Asp Val Ile Ile His Glu Ile Ser His Ser Trp Phe Gly Asn Leu Val 
                325                 330                 335     


Thr Asn Ala Asn Trp Gly Glu Phe Trp Leu Asn Glu Gly Phe Thr Met 
            340                 345                 350         


Tyr Ala Gln Arg Arg Ile Ser Thr Ile Leu Phe Gly Ala Ala Tyr Thr 
        355                 360                 365             


Cys Leu Glu Ala Ala Thr Gly Arg Ala Leu Leu Arg Gln His Met Asp 
    370                 375                 380                 


Ile Thr Gly Glu Glu Asn Pro Leu Asn Lys Leu Arg Val Lys Ile Glu 
385                 390                 395                 400 


Pro Gly Val Asp Pro Asp Asp Thr Tyr Asn Glu Thr Pro Tyr Glu Lys 
                405                 410                 415     


Gly Phe Cys Phe Val Ser Tyr Leu Ala His Leu Val Gly Asp Gln Asp 
            420                 425                 430         


Gln Phe Asp Ser Phe Leu Lys Ala Tyr Val His Glu Phe Lys Phe Arg 
        435                 440                 445             


Ser Ile Leu Ala Asp Asp Phe Leu Asp Phe Tyr Leu Glu Tyr Phe Pro 
    450                 455                 460                 


Glu Leu Lys Lys Lys Arg Val Asp Ile Ile Pro Gly Phe Glu Phe Asp 
465                 470                 475                 480 


Arg Trp Leu Asn Thr Pro Gly Trp Pro Pro Tyr Leu Pro Asp Leu Ser 
                485                 490                 495     


Pro Gly Asp Ser Leu Met Lys Pro Ala Glu Glu Leu Ala Gln Leu Trp 
            500                 505                 510         


Ala Ala Glu Glu Leu Asp Met Lys Ala Ile Glu Ala Val Ala Ile Ser 
        515                 520                 525             


Pro Trp Lys Thr Tyr Gln Leu Val Tyr Phe Leu Asp Lys Ile Leu Gln 
    530                 535                 540                 


Lys Ser Pro Leu Pro Pro Gly Asn Val Lys Lys Leu Gly Asp Thr Tyr 
545                 550                 555                 560 


Pro Ser Ile Ser Asn Ala Arg Asn Ala Glu Leu Arg Leu Arg Trp Gly 
                565                 570                 575     


Gln Ile Val Leu Lys Asn Asp His Gln Glu Asp Phe Trp Lys Val Lys 
            580                 585                 590         


Glu Phe Leu His Asn Gln Gly Lys Gln Lys Tyr Thr Leu Pro Leu Tyr 
        595                 600                 605             


His Ala Met Met Gly Gly Ser Glu Val Ala Gln Thr Leu Ala Lys Glu 
    610                 615                 620                 


Thr Phe Ala Ser Thr Ala Ser Gln Leu His Ser Asn Val Val Asn Tyr 
625                 630                 635                 640 


Val Gln Gln Ile Val Ala Pro Lys Gly Ser 
                645                 650 


<210>  377
<211>  1914
<212>  DNA
<213>  Homosapiens

<400>  377
agttgaccaa ccatgccttg aggataaatt ggatgggatc agatgggaag atgtgacaag     60

aagagaaatc ctcctctata taggatgctc tgctgtttcc taaggatttt cagcaccttg    120

ccccaaaatc aaaatgatgc ttcaacaccc aggccaggtc tctgcctcgg aagtgagtgc    180

ttctgccatc gtcccctgcc tgtcccctcc tgggtcactg gtgtttgagg attttgctaa    240

cctgacgccc tttgtcaagg aagagctgag gtttgccatc cagaacaagc acctctgcca    300

ccggatgtcc tctgcgctgg aatcagtcac tgtcagcgac agacccctcg gggtgtccat    360

cacaaaagcc gaggtagccc ctgaagaaga tgaaaggaaa aagaggcgac gagaaagaaa    420

taagattgca gctgcaaagt gccgaaacaa gaagaaggag aagacggagt gcctgcagaa    480

agagtcggag aagctggaaa gtgtgaatgc tgaactgaag gctcagattg aggagctcaa    540

gaacgagaag cagcatttga tatacatgct caaccttcat cggcccacgt gtattgtccg    600

ggctcagaat gggaggactc cagaagatga gagaaacctc tttatccaac agataaaaga    660

aggaacattg cagagctaag cagtcgtggt atgggggcga ctggggagtc ctcattgaat    720

cctcatttta tacccaaaac cctgaagcca ttggagagct gtcttcctgt gtacctctag    780

aatcccagca gcagagaacc atcaaggcgg gagggcctgc agtgattcag caggcccttc    840

ccattctgcc ccagagtggg tcttggacca gggcaagtgc atctttgcct caactccagg    900

atttaggcct taacacactg gccattctta tgttccagat ggcccccagc tggtgtcctg    960

cccgcctttc atctggattc tacaaaaaac caggatgccc accgttagga ttcaggcagc   1020

agtgtctgta cctcgggtgg gagggatggg gccatctcct tcaccgtggc taccattgtc   1080

actcgtaggg gatgtggagt gagaacagca tttagtgaag ttgtgcaacg gccagggttg   1140

tgctttctag caaatatgct gttatgtcca gaaattgtgt gtgcaagaaa actaggcaat   1200

gtactcttcc gatgtttgtg tcacacaaca ctgatgtgac ttttatatgc tttttctcag   1260

atctggtttc taagagtttt ggggggcggg gctgtcacca cgtgcagtat ctcaagatat   1320

tcaggtggcc agaagagctt gtcagcaaga ggaggacaga attctcccag cgttaacaca   1380

aaatccatgg gcagtatgat ggcaggtcct ctgttgcaaa ctcagttcca aagtcacagg   1440

aagaaagcag aaagttcaac ttccaaaggg ttaggactct ccactcaatg tcttaggtca   1500

ggagttgtgt ctaggctgga agagccaaag aatattccat tttcctttcc ttgtggttga   1560

aaaccacagt cagtggagag atgtttggaa accacagtca gtggagcctg ggtggtaccc   1620

aggctttagc attattggat gtcaatagca ttgtttttgt catgtagctg ttttaagaaa   1680

tctggcccag ggtgtttgca gctgtgagaa gtcactcaca ctggccacaa ggacgctggc   1740

tactgtctat taaaattctg atgtttctgt gaaattctca gagtgtttaa ttgtactcaa   1800

tggtatcatt acaattttct gtaagagaaa atattactta tttatcctag tattcctaac   1860

ctgtcagaat aataaatatt ggaaccaaga catggtaaaa aaaaaaaaaa aaaa         1914


<210>  378
<211>  181
<212>  PRT
<213>  Homosapiens

<400>  378

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Glu Ser Glu Lys Leu Glu Ser Val Asn Ala Glu Leu 
        115                 120                 125             


Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln His Leu Ile Tyr 
    130                 135                 140                 


Met Leu Asn Leu His Arg Pro Thr Cys Ile Val Arg Ala Gln Asn Gly 
145                 150                 155                 160 


Arg Thr Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln Gln Ile Lys Glu 
                165                 170                 175     


Gly Thr Leu Gln Ser 
            180     


<210>  379
<211>  2361
<212>  DNA
<213>  Homosapiens

<400>  379
cgggaagcta ttaatagcat tacgtcagcc tgggactggc aacacggagt aaacgaccgc     60

gccgccagcc tgagggctat aaaaggggtg atgcaacgct ctccaagcca cagtcgcacg    120

cagccaggcg cgcactgcac agctctcttc tctcgccgcc gcccgagcgc acccttcagc    180

ccgcgcgccg gccgtgagtc ctcggtgctc gcccgccggc cagacaaaca gcccgcccga    240

ccccgtcccg accctggccg ccccgagcgg agcctggagc aaaatgatgc ttcaacaccc    300

aggccaggtc tctgcctcgg aagtgagtgc ttctgccatc gtcccctgcc tgtcccctcc    360

tgggtcactg gtgtttgagg attttgctaa cctgacgccc tttgtcaagg aagagctgag    420

gtttgccatc cagaacaagc acctctgcca ccggatgtcc tctgcgctgg aatcagtcac    480

tgtcagcgac agacccctcg gggtgtccat cacaaaagcc gaggtagccc ctgaagaaga    540

tgaaaggaaa aagaggcgac gagaaagaaa taagattgca gctgcaaagt gccgaaacaa    600

gaagaaggag aagacggagt gcctgcagaa actcccaagg cccttttggg tccagaagac    660

ctgcatatgg gctgttgact catgcaaatg aggtatctga actgcagctt cagtattagc    720

agagccacag gccgcctctg tggcatcacc agggtttctc tgaagaagag ggtctgcatt    780

ttcctaaacc cagtgctgct ctcccatctc ccatcttcct ctcgcagctt gatgagcccc    840

ggtgtgtccc aggtacaccc ctgcatccag gcagcagccc aggccacccc ctcctcactg    900

gcccttggct cctttcttga tgcctctgtt gcttgtcccc caggagtcgg agaagctgga    960

aagtgtgaat gctgaactga aggctcagat tgaggagctc aagaacgaga agcagcattt   1020

gatatacatg ctcaaccttc atcggcccac gtgtattgtc cgggctcaga atgggaggac   1080

tccagaagat gagagaaacc tctttatcca acagataaaa gaaggaacat tgcagagcta   1140

agcagtcgtg gtatgggggc gactggggag tcctcattga atcctcattt tatacccaaa   1200

accctgaagc cattggagag ctgtcttcct gtgtacctct agaatcccag cagcagagaa   1260

ccatcaaggc gggagggcct gcagtgattc agcaggccct tcccattctg ccccagagtg   1320

ggtcttggac cagggcaagt gcatctttgc ctcaactcca ggatttaggc cttaacacac   1380

tggccattct tatgttccag atggccccca gctggtgtcc tgcccgcctt tcatctggat   1440

tctacaaaaa accaggatgc ccaccgttag gattcaggca gcagtgtctg tacctcgggt   1500

gggagggatg gggccatctc cttcaccgtg gctaccattg tcactcgtag gggatgtgga   1560

gtgagaacag catttagtga agttgtgcaa cggccagggt tgtgctttct agcaaatatg   1620

ctgttatgtc cagaaattgt gtgtgcaaga aaactaggca atgtactctt ccgatgtttg   1680

tgtcacacaa cactgatgtg acttttatat gctttttctc agatctggtt tctaagagtt   1740

ttggggggcg gggctgtcac cacgtgcagt atctcaagat attcaggtgg ccagaagagc   1800

ttgtcagcaa gaggaggaca gaattctccc agcgttaaca caaaatccat gggcagtatg   1860

atggcaggtc ctctgttgca aactcagttc caaagtcaca ggaagaaagc agaaagttca   1920

acttccaaag ggttaggact ctccactcaa tgtcttaggt caggagttgt gtctaggctg   1980

gaagagccaa agaatattcc attttccttt ccttgtggtt gaaaaccaca gtcagtggag   2040

agatgtttgg aaaccacagt cagtggagcc tgggtggtac ccaggcttta gcattattgg   2100

atgtcaatag cattgttttt gtcatgtagc tgttttaaga aatctggccc agggtgtttg   2160

cagctgtgag aagtcactca cactggccac aaggacgctg gctactgtct attaaaattc   2220

tgatgtttct gtgaaattct cagagtgttt aattgtactc aatggtatca ttacaatttt   2280

ctgtaagaga aaatattact tatttatcct agtattccta acctgtcaga ataataaata   2340

ttggaaccaa gacatggtaa a                                             2361


<210>  380
<211>  135
<212>  PRT
<213>  Homosapiens

<400>  380

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Leu Pro Arg Pro Phe Trp Val Gln Lys Thr Cys Ile 
        115                 120                 125             


Trp Ala Val Asp Ser Cys Lys 
    130                 135 


<210>  381
<211>  2049
<212>  DNA
<213>  Homosapiens

<400>  381
cgggaagcta ttaatagcat tacgtcagcc tgggactggc aacacggagt aaacgaccgc     60

gccgccagcc tgagggctat aaaaggggtg atgcaacgct ctccaagcca cagtcgcacg    120

cagccaggcg cgcactgcac agctctcttc tctcgccgcc gcccgagcgc acccttcagc    180

ccgcgcgccg gccgtgagtc ctcggtgctc gcccgccggc cagacaaaca gcccgcccga    240

ccccgtcccg accctggccg ccccgagcgg agcctggagc aaaatgatgc ttcaacaccc    300

aggccaggtc tctgcctcgg aagtgagtgc ttctgccatc gtcccctgcc tgtcccctcc    360

tgggtcactg gtgtttgagg attttgctaa cctgacgccc tttgtcaagg aagagctgag    420

gtttgccatc cagaacaagc acctctgcca ccggatgtcc tctgcgctgg aatcagtcac    480

tgtcagcgac agacccctcg gggtgtccat cacaaaagcc gaggtagccc ctgaagaaga    540

tgaaaggaaa aagaggcgac gagaaagaaa taagattgca gctgcaaagt gccgaaacaa    600

gaagaaggag aagacggagt gcctgcagaa agagtcggag aagctggaaa gtgtgaatgc    660

tgaactgaag gctcagattg aggagctcaa gaacgagaag cagcatttga tatacatgct    720

caaccttcat cggcccacgt gtattgtccg ggctcagaat gggaggactc cagaagatga    780

gagaaacctc tttatccaac agataaaaga aggaacattg cagagctaag cagtcgtggt    840

atgggggcga ctggggagtc ctcattgaat cctcatttta tacccaaaac cctgaagcca    900

ttggagagct gtcttcctgt gtacctctag aatcccagca gcagagaacc atcaaggcgg    960

gagggcctgc agtgattcag caggcccttc ccattctgcc ccagagtggg tcttggacca   1020

gggcaagtgc atctttgcct caactccagg atttaggcct taacacactg gccattctta   1080

tgttccagat ggcccccagc tggtgtcctg cccgcctttc atctggattc tacaaaaaac   1140

caggatgccc accgttagga ttcaggcagc agtgtctgta cctcgggtgg gagggatggg   1200

gccatctcct tcaccgtggc taccattgtc actcgtaggg gatgtggagt gagaacagca   1260

tttagtgaag ttgtgcaacg gccagggttg tgctttctag caaatatgct gttatgtcca   1320

gaaattgtgt gtgcaagaaa actaggcaat gtactcttcc gatgtttgtg tcacacaaca   1380

ctgatgtgac ttttatatgc tttttctcag atctggtttc taagagtttt ggggggcggg   1440

gctgtcacca cgtgcagtat ctcaagatat tcaggtggcc agaagagctt gtcagcaaga   1500

ggaggacaga attctcccag cgttaacaca aaatccatgg gcagtatgat ggcaggtcct   1560

ctgttgcaaa ctcagttcca aagtcacagg aagaaagcag aaagttcaac ttccaaaggg   1620

ttaggactct ccactcaatg tcttaggtca ggagttgtgt ctaggctgga agagccaaag   1680

aatattccat tttcctttcc ttgtggttga aaaccacagt cagtggagag atgtttggaa   1740

accacagtca gtggagcctg ggtggtaccc aggctttagc attattggat gtcaatagca   1800

ttgtttttgt catgtagctg ttttaagaaa tctggcccag ggtgtttgca gctgtgagaa   1860

gtcactcaca ctggccacaa ggacgctggc tactgtctat taaaattctg atgtttctgt   1920

gaaattctca gagtgtttaa ttgtactcaa tggtatcatt acaattttct gtaagagaaa   1980

atattactta tttatcctag tattcctaac ctgtcagaat aataaatatt ggaaccaaga   2040

catggtaaa                                                           2049


<210>  382
<211>  181
<212>  PRT
<213>  Homosapiens

<400>  382

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Glu Ser Glu Lys Leu Glu Ser Val Asn Ala Glu Leu 
        115                 120                 125             


Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln His Leu Ile Tyr 
    130                 135                 140                 


Met Leu Asn Leu His Arg Pro Thr Cys Ile Val Arg Ala Gln Asn Gly 
145                 150                 155                 160 


Arg Thr Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln Gln Ile Lys Glu 
                165                 170                 175     


Gly Thr Leu Gln Ser 
            180     


<210>  383
<211>  2270
<212>  DNA
<213>  Homosapiens

<400>  383
cgggaagcta ttaatagcat tacgtcagcc tgggactggc aacacggagt aaacgaccgc     60

gccgccagcc tgagggctat aaaaggggtg atgcaacgct ctccaagcca cagtcgcacg    120

cagccaggcg cgcactgcac agctctcttc tctcgccgcc gcccgagcgc acccttcagc    180

ccgcgcgccg gccgtgagtc ctcggtgctc gcccgccggc cagacaaaca gcccgcccga    240

ccccgtcccg accctggccg ccccgagcgg agcctggagc aaaatgatgc ttcaacaccc    300

aggccaggtc tctgcctcgg aagtgagtgc ttctgccatc gtcccctgcc tgtcccctcc    360

tgggtcactg gtgtttgagg attttgctaa cctgacgccc tttgtcaagg aagagctgag    420

gtttgccatc cagaacaagc acctctgcca ccggatgtcc tctgcgctgg aatcagtcac    480

tgtcagcgac agacccctcg gggtgtccat cacaaaagcc gaggtagccc ctgaagaaga    540

tgaaaggaaa aagaggcgac gagaaagaaa taagattgca gctgcaaagt gccgaaacaa    600

gaagaaggag aagacggagt gcctgcagaa actcccaagg cccttttggg tccagaagac    660

ctgcatatgg gctgttgact catgcaaatg aggtatctga actgcagctt cagtattagc    720

agagccacag gccgcctctg tggcatcacc agggtttctc tgaagaagag ggtctgcatt    780

ttcctaaacc cagtgctgct ctcccatctc ccatcttcct ctcgcagctt gatgagcccc    840

ggtgtgtccc aggagtcgga gaagctggaa agtgtgaatg ctgaactgaa ggctcagatt    900

gaggagctca agaacgagaa gcagcatttg atatacatgc tcaaccttca tcggcccacg    960

tgtattgtcc gggctcagaa tgggaggact ccagaagatg agagaaacct ctttatccaa   1020

cagataaaag aaggaacatt gcagagctaa gcagtcgtgg tatgggggcg actggggagt   1080

cctcattgaa tcctcatttt atacccaaaa ccctgaagcc attggagagc tgtcttcctg   1140

tgtacctcta gaatcccagc agcagagaac catcaaggcg ggagggcctg cagtgattca   1200

gcaggccctt cccattctgc cccagagtgg gtcttggacc agggcaagtg catctttgcc   1260

tcaactccag gatttaggcc ttaacacact ggccattctt atgttccaga tggcccccag   1320

ctggtgtcct gcccgccttt catctggatt ctacaaaaaa ccaggatgcc caccgttagg   1380

attcaggcag cagtgtctgt acctcgggtg ggagggatgg ggccatctcc ttcaccgtgg   1440

ctaccattgt cactcgtagg ggatgtggag tgagaacagc atttagtgaa gttgtgcaac   1500

ggccagggtt gtgctttcta gcaaatatgc tgttatgtcc agaaattgtg tgtgcaagaa   1560

aactaggcaa tgtactcttc cgatgtttgt gtcacacaac actgatgtga cttttatatg   1620

ctttttctca gatctggttt ctaagagttt tggggggcgg ggctgtcacc acgtgcagta   1680

tctcaagata ttcaggtggc cagaagagct tgtcagcaag aggaggacag aattctccca   1740

gcgttaacac aaaatccatg ggcagtatga tggcaggtcc tctgttgcaa actcagttcc   1800

aaagtcacag gaagaaagca gaaagttcaa cttccaaagg gttaggactc tccactcaat   1860

gtcttaggtc aggagttgtg tctaggctgg aagagccaaa gaatattcca ttttcctttc   1920

cttgtggttg aaaaccacag tcagtggaga gatgtttgga aaccacagtc agtggagcct   1980

gggtggtacc caggctttag cattattgga tgtcaatagc attgtttttg tcatgtagct   2040

gttttaagaa atctggccca gggtgtttgc agctgtgaga agtcactcac actggccaca   2100

aggacgctgg ctactgtcta ttaaaattct gatgtttctg tgaaattctc agagtgttta   2160

attgtactca atggtatcat tacaattttc tgtaagagaa aatattactt atttatccta   2220

gtattcctaa cctgtcagaa taataaatat tggaaccaag acatggtaaa              2270


<210>  384
<211>  135
<212>  PRT
<213>  Homosapiens

<400>  384

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Leu Pro Arg Pro Phe Trp Val Gln Lys Thr Cys Ile 
        115                 120                 125             


Trp Ala Val Asp Ser Cys Lys 
    130                 135 


<210>  385
<211>  2321
<212>  DNA
<213>  Homosapiens

<400>  385
agagagaggg tcgtcacttc ctgtcactag gactacagtt tgtagtctct ctcagggaga     60

gagactacaa actgtagtta aaaaaatcag aggtggaggt cagggggtta ggtccagaag    120

aaaacctctc tggagcccac cctgcatctc tacgtcttgg aagagtctgg agtccaggca    180

ccctacagca ccccccacag caatcatccg tgctcccacc cccaccccgg cctctgggag    240

gctctgaggc aacagtgggg gcctgtgggg tggggtggga ttgagagacc agctgcagag    300

acatctttgt gacccaggag caccactggt ccctcatctg ccaccgaggc caaggaagac    360

ccagagacct gcctcaccag tgctgccgtt gtgctgaaag acaaccatga atgctgattt    420

tctgctgccg tattatacgg cccagagtgg ctccagcatg agcatgttcg acaccaccat    480

ggggaaactg cagcgacaac tgtacaaggg ggagtacgat atattcaagt atgcaccgat    540

atttgagagc gactttatcc agatcaccaa aaggggagaa gtgattgatg tgcacaaccg    600

tgtccgtatg gtgaccatgg gcattgcacg taccagcccc atcctcccac tcccagatgt    660

catgctactg gcacgaccgg ccaccggctg cgaagagtat gctggacatg gccaggccac    720

caagagaaaa aaacgcaagg cagcaaagaa cttagagctc accaggcttc tgcccctgag    780

gtttgtacgg atctctgttc aagaccatga gaaacaacag ctgcgcctga agttcgccac    840

tggcagatct tgctatctgc aattgtgtcc cgctcttgac acacgggatg acctctttgc    900

ctattgggaa aaactaattt acctcttgcg gccacccatg gagagtaaca gcagtacctg    960

tggcattcca gctgaagaca tgatgtggat gcctgtgttt caggaagaca ggaggagcct   1020

gggagccgtg aaccttcaag gaaaggggga tcaggaccag gtcagcatcc aaagcctcca   1080

catggtctct gaggtgtgtg gggccacctc tgctgcttat gctggagggg agggactcca   1140

aaatgacttt aacaaaccca ctaatgtgct caatgcatcc atccccaaaa catctacaga   1200

acttgctgag gagccagcaa caggggggat taaagaggca gcagcagcag gggcagctgc   1260

aggggcagca acaggcaccg tagcaggtgc cttgagtgtg gcagcagcca attctgcccc   1320

tggacaggtg agcgcagcca tagctggggc ggccaccatc gatgcaggag gaaacaaagg   1380

caacatggcc cttgcaggca ctgccagcat ggctccaaac agcacgaagg tggctgtggc   1440

aggggctgca ggcaagtcct cagagcatgt ttccagcgca tccatgagcc tttcccgaga   1500

gggcagtgtg agcctggcca ttgcaggagt agtactgacc agcaggacag ctgcagaagc   1560

agacatggat gcagcagcgg gacctcccgt ctccacccgg cagagcaaga gcagcctgag   1620

tggacagcat ggaagggagc gaacccaggc cagcgctgaa ggctgcaagg aggggaggga   1680

aagaagggaa aaggacaggg ctctcggaag gagttcccat cgccgcagga caggtgaaag   1740

ccgccacaaa acaaggggag acaagattgc ccaaaagtcc tccagcaggt cctcattcag   1800

ccacagagcc aatagagatg acaaaaagga gaaaggctgt ggcaacccgg ggagcagcag   1860

gcacagggac tcgcataaag gtgtcagcca cacgcccatc tcaaaggagt ccaggacctc   1920

tcacaaatct gggaggagct tatggaccac cagttccggt tccagcaagg gacttggcag   1980

ggtcagctct ttcctgagga acgtcagagc caaccttact acaaaagtag tgggcacacc   2040

acatggcaga gatgtggacg tcatggctaa gatggcggag aggagcacca acgtggccat   2100

cgccgagaca gcagagggtg gccaggggct ggagatggtt ggttctatga caccggacat   2160

catggagaca gtgacctttg aagcccatta aataagaccc agagctggaa gctgcaaagg   2220

agcccagagc tcatgggagt gtccctggaa agcctattcc agcgttcttt actgccgttt   2280

aaataaagaa tcatacatct gaaaacaaaa aaaaaaaaaa a                       2321


<210>  386
<211>  594
<212>  PRT
<213>  Homosapiens

<400>  386

Met Asn Ala Asp Phe Leu Leu Pro Tyr Tyr Thr Ala Gln Ser Gly Ser 
1               5                   10                  15      


Ser Met Ser Met Phe Asp Thr Thr Met Gly Lys Leu Gln Arg Gln Leu 
            20                  25                  30          


Tyr Lys Gly Glu Tyr Asp Ile Phe Lys Tyr Ala Pro Ile Phe Glu Ser 
        35                  40                  45              


Asp Phe Ile Gln Ile Thr Lys Arg Gly Glu Val Ile Asp Val His Asn 
    50                  55                  60                  


Arg Val Arg Met Val Thr Met Gly Ile Ala Arg Thr Ser Pro Ile Leu 
65                  70                  75                  80  


Pro Leu Pro Asp Val Met Leu Leu Ala Arg Pro Ala Thr Gly Cys Glu 
                85                  90                  95      


Glu Tyr Ala Gly His Gly Gln Ala Thr Lys Arg Lys Lys Arg Lys Ala 
            100                 105                 110         


Ala Lys Asn Leu Glu Leu Thr Arg Leu Leu Pro Leu Arg Phe Val Arg 
        115                 120                 125             


Ile Ser Val Gln Asp His Glu Lys Gln Gln Leu Arg Leu Lys Phe Ala 
    130                 135                 140                 


Thr Gly Arg Ser Cys Tyr Leu Gln Leu Cys Pro Ala Leu Asp Thr Arg 
145                 150                 155                 160 


Asp Asp Leu Phe Ala Tyr Trp Glu Lys Leu Ile Tyr Leu Leu Arg Pro 
                165                 170                 175     


Pro Met Glu Ser Asn Ser Ser Thr Cys Gly Ile Pro Ala Glu Asp Met 
            180                 185                 190         


Met Trp Met Pro Val Phe Gln Glu Asp Arg Arg Ser Leu Gly Ala Val 
        195                 200                 205             


Asn Leu Gln Gly Lys Gly Asp Gln Asp Gln Val Ser Ile Gln Ser Leu 
    210                 215                 220                 


His Met Val Ser Glu Val Cys Gly Ala Thr Ser Ala Ala Tyr Ala Gly 
225                 230                 235                 240 


Gly Glu Gly Leu Gln Asn Asp Phe Asn Lys Pro Thr Asn Val Leu Asn 
                245                 250                 255     


Ala Ser Ile Pro Lys Thr Ser Thr Glu Leu Ala Glu Glu Pro Ala Thr 
            260                 265                 270         


Gly Gly Ile Lys Glu Ala Ala Ala Ala Gly Ala Ala Ala Gly Ala Ala 
        275                 280                 285             


Thr Gly Thr Val Ala Gly Ala Leu Ser Val Ala Ala Ala Asn Ser Ala 
    290                 295                 300                 


Pro Gly Gln Val Ser Ala Ala Ile Ala Gly Ala Ala Thr Ile Asp Ala 
305                 310                 315                 320 


Gly Gly Asn Lys Gly Asn Met Ala Leu Ala Gly Thr Ala Ser Met Ala 
                325                 330                 335     


Pro Asn Ser Thr Lys Val Ala Val Ala Gly Ala Ala Gly Lys Ser Ser 
            340                 345                 350         


Glu His Val Ser Ser Ala Ser Met Ser Leu Ser Arg Glu Gly Ser Val 
        355                 360                 365             


Ser Leu Ala Ile Ala Gly Val Val Leu Thr Ser Arg Thr Ala Ala Glu 
    370                 375                 380                 


Ala Asp Met Asp Ala Ala Ala Gly Pro Pro Val Ser Thr Arg Gln Ser 
385                 390                 395                 400 


Lys Ser Ser Leu Ser Gly Gln His Gly Arg Glu Arg Thr Gln Ala Ser 
                405                 410                 415     


Ala Glu Gly Cys Lys Glu Gly Arg Glu Arg Arg Glu Lys Asp Arg Ala 
            420                 425                 430         


Leu Gly Arg Ser Ser His Arg Arg Arg Thr Gly Glu Ser Arg His Lys 
        435                 440                 445             


Thr Arg Gly Asp Lys Ile Ala Gln Lys Ser Ser Ser Arg Ser Ser Phe 
    450                 455                 460                 


Ser His Arg Ala Asn Arg Asp Asp Lys Lys Glu Lys Gly Cys Gly Asn 
465                 470                 475                 480 


Pro Gly Ser Ser Arg His Arg Asp Ser His Lys Gly Val Ser His Thr 
                485                 490                 495     


Pro Ile Ser Lys Glu Ser Arg Thr Ser His Lys Ser Gly Arg Ser Leu 
            500                 505                 510         


Trp Thr Thr Ser Ser Gly Ser Ser Lys Gly Leu Gly Arg Val Ser Ser 
        515                 520                 525             


Phe Leu Arg Asn Val Arg Ala Asn Leu Thr Thr Lys Val Val Gly Thr 
    530                 535                 540                 


Pro His Gly Arg Asp Val Asp Val Met Ala Lys Met Ala Glu Arg Ser 
545                 550                 555                 560 


Thr Asn Val Ala Ile Ala Glu Thr Ala Glu Gly Gly Gln Gly Leu Glu 
                565                 570                 575     


Met Val Gly Ser Met Thr Pro Asp Ile Met Glu Thr Val Thr Phe Glu 
            580                 585                 590         


Ala His 
        


<210>  387
<211>  980
<212>  DNA
<213>  Homosapiens

<400>  387
ggggcagacg tgggacggga aggacggctg ccgggactgg cgcgcgggga cactgggccg     60

acgcgtggag tagcggggag agcgggaagc ctgagggggc ggggccggcg cgaggccgtg    120

ggtgcggcac gaggatgccg gcggcgggac agcgcccgta ggcagcccca cgggcagggc    180

gcgcgggcgg ggcggggcgg gccgggccag aggagctccc ggcatgtcgc aagggctccc    240

ggccgccggc agcgtcctgc agaggagcgt cgcggcgccc gggaaccagc cgcagccgca    300

gccgcagcag cagagccctg aggatgatga caggaaggtc cgaaggagag aaaaaaaccg    360

agttgctgct cagagaagtc ggaagaagca gacccagaag gctgacaagc tccatgagga    420

atatgagagc ctggagcaag aaaacaccat gctgcggaga gagatcggga agctgacaga    480

ggagctgaag cacctgacag aggcactgaa ggagcacgag aagatgtgcc cgctgctgct    540

ctgccctatg aactttgtgc cagtgcctcc ccggccggac cctgtggccg gctgcttgcc    600

ccgatgaagc cggggacact cctctgccca gcaaggagcc ttggtcattt tcatacctgg    660

gaggaaggct tttccttcac aattgtatac agggggcacc tgtggccagg cctcctcctg    720

ggagctccag gaccagccag ctgtgttccc tgcagactgg gctcagcccg acatccaaca    780

ggcgccaaac tcacagagcc cttgtgcaga tccagcatgg aggccaccct caggagtgac    840

ttctcatcca ccctggcagc tagtaggttc tgctgttatg cagagccatt tcctctagaa    900

tttggataat aaagatgctt attgtctctc ccttctccag ttctgggaat ttacaggcac    960

aatacacttc cttttcctgg                                                980


<210>  388
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  388

Met Ser Gln Gly Leu Pro Ala Ala Gly Ser Val Leu Gln Arg Ser Val 
1               5                   10                  15      


Ala Ala Pro Gly Asn Gln Pro Gln Pro Gln Pro Gln Gln Gln Ser Pro 
            20                  25                  30          


Glu Asp Asp Asp Arg Lys Val Arg Arg Arg Glu Lys Asn Arg Val Ala 
        35                  40                  45              


Ala Gln Arg Ser Arg Lys Lys Gln Thr Gln Lys Ala Asp Lys Leu His 
    50                  55                  60                  


Glu Glu Tyr Glu Ser Leu Glu Gln Glu Asn Thr Met Leu Arg Arg Glu 
65                  70                  75                  80  


Ile Gly Lys Leu Thr Glu Glu Leu Lys His Leu Thr Glu Ala Leu Lys 
                85                  90                  95      


Glu His Glu Lys Met Cys Pro Leu Leu Leu Cys Pro Met Asn Phe Val 
            100                 105                 110         


Pro Val Pro Pro Arg Pro Asp Pro Val Ala Gly Cys Leu Pro Arg 
        115                 120                 125         


<210>  389
<211>  1712
<212>  DNA
<213>  Homosapiens

<400>  389
cccacagttt tcgacgaaaa atggcggggt ctcctgagtt ggtggtcctt gaccctccat     60

gggacaagga gctcgcggct ggcacagaga gccaggcctt ggtctccgcc actccccgag    120

aagactttcg ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta caactgtgcg    180

gccgcttcgt gcaaaagctc ggggacgctc tgccggagga gattcgggag cccgctctgc    240

gagatgcgca gtggactttt gaatcagctg tgcaagagaa tatcagcatt aatgggcaag    300

catggcagga agcttcagat aattgtttta tggattctga catcaaagta cttgaagatc    360

agtttgatga aatcatagta gatatagcca caaaacgtaa gcagtatccc agaaagatcc    420

tggaatgtgt catcaaaacc ataaaagcaa aacaagaaat tctgaagcag taccaccctg    480

ttgtacatcc actggaccta aaatatgacc ctgatccagc ccctcatatg gaaaatttga    540

aatgcagagg ggaaacagta gcaaaggaga tcagtgaagc catgaagtcc ttgcctgcat    600

taattgaaca aggagaggga ttttcccaag ttctcaggat gcagcctgtt atccacctcc    660

agaggattca ccaagaagtc ttttccagtt gtcataggaa accagatgct aaacctgaga    720

actttataac acagatagaa accacaccaa cagagactgc ttccaggaaa acctctgacg    780

tggtactgaa aagaaagcaa actaaagact gcccccagag aaaatggtat ccattgcggc    840

caaagaaaat taatcttgat acatgagctc tttctgttta ttttgggagt tgaaaatagg    900

caccatcaac atttagatta cagcctaatt aatacctaga taagacttca tttgaaataa    960

gaaataactc ttttactagt gattcattta tacagatata gtatctctgt gcggggatat   1020

gatataatat tgtatttcct tactgtttta tctattgtaa ataaaaagca ttttaaaaag   1080

tattgacaca aagcccatca gtgggcatta aaaatattaa aagtgcagac ttttactgtc   1140

cttaagtgcc atcaactctc agctcccttg tagcttttgt gggatttaac aagtaacaaa   1200

ttctgttgtg tttccctggt atacatcttt ctaggaaaaa aaaaaaaaga gagagagctg   1260

tataatgatt tttcgtttac atgctgaaaa gtaattatca gtttctgcac agcagcagat   1320

gcagggtttt tttttaaaga tgtagtttga tttatcaaat taatgtgctg atgataatac   1380

tggctttgac tttgttactc catgttcagc taatttaggt ttgtgagatt aactttagga   1440

ttttttgttg tgtaagacaa tgataactat tatttgtgca acattactct ttgaaataaa   1500

aattggcatg tagccaatgt ttcctgccca cactcacttt tttctataga ccattaacat   1560

aatttgactt ggaactaatg gtttcttttt agggtttctt atttatttct ttacaaatca   1620

ttccagttca aaatatatat cagattaata cactgaaaaa aaagtgtcat tgtggtttat   1680

tggaacctat tttcaccttg gagggtggtt ta                                 1712


<210>  390
<211>  281
<212>  PRT
<213>  Homosapiens

<400>  390

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Ala Pro His Met Glu Asn Leu Lys Cys Arg 
                165                 170                 175     


Gly Glu Thr Val Ala Lys Glu Ile Ser Glu Ala Met Lys Ser Leu Pro 
            180                 185                 190         


Ala Leu Ile Glu Gln Gly Glu Gly Phe Ser Gln Val Leu Arg Met Gln 
        195                 200                 205             


Pro Val Ile His Leu Gln Arg Ile His Gln Glu Val Phe Ser Ser Cys 
    210                 215                 220                 


His Arg Lys Pro Asp Ala Lys Pro Glu Asn Phe Ile Thr Gln Ile Glu 
225                 230                 235                 240 


Thr Thr Pro Thr Glu Thr Ala Ser Arg Lys Thr Ser Asp Val Val Leu 
                245                 250                 255     


Lys Arg Lys Gln Thr Lys Asp Cys Pro Gln Arg Lys Trp Tyr Pro Leu 
            260                 265                 270         


Arg Pro Lys Lys Ile Asn Leu Asp Thr 
        275                 280     


<210>  391
<211>  2362
<212>  DNA
<213>  Homosapiens

<400>  391
tcaggacgct gcagctgaaa cgttccggct ccggctctgc tggccggtct aaagcggcag     60

ccgccggggc gcaatgcgag cggctggcgt aggcttggtg gactgtcact gccacctctc    120

cgccccggac tttgaccgcg atttggatga tgtgttggag aaagccaaga aggccaatgt    180

tgtggccctt gtggcagttg ccgaacattc aggagaattt gaaaagatta tgcaactttc    240

agaaaggtat aatgggtttg tcctgccatg cttgggtgtt catccagttc aaggacttcc    300

accagaagac caaagaagtg tcacactaaa ggatttggat gtagctttgc ccattattga    360

gaattataag gatcggttgt tggcaattgg agaggttgga ctagatttct cccccagatt    420

tgctggcact ggtgaacaga aggaagagca aagacaagtc ctaatcagac agatccagtt    480

agccaaaaga ctaaatttgc ctgtaaatgt gcactcacgc tctgctggaa gacctaccat    540

caacctttta caagagcaag gtgctgagaa ggtactgctg catgcatttg atggtcggcc    600

atctgtagcc atggaaggag taagagctgg gtacttcttc tcaattcccc cttctatcat    660

aagaagtgga cagaagcaga aacttgtgaa acaattgcct ttaacttcta tatgcttaga    720

aacagattca cctgcactag gaccagaaaa acaggtacgg aatgagccct ggaacatttc    780

tatttcagca gaatatattg cccaggtgaa agggatctca gtggaagaag ttatagaagt    840

gacgacacag aatgcattaa aactgtttcc taagctccga cacttgctcc agaaatagct    900

tcaaaaccat ccattacaaa atcgaatcaa ctgcaggggg cagcatttga aaaatagaaa    960

tgttctgatg aagaatctga actgaagaag ctgttttata gggttataga agattgtaat   1020

tgtagagaaa tatttctctt agaaataaaa ctgggcttgg atcctgaaac cctgggttct   1080

gattctagcc ttgtgctgct tttcaattag ccgagttctg gcaggatatt gggaaaatac   1140

tgctacttct tacattgccc ttttatatag aaccaccacc tgaactgaaa ccattgctac   1200

tgggaagggt ggctcccaca ggaagagtat aagcactact gtgatgagga tggagtaagc   1260

taaagtatac tttttttttt ttttgatgga gtttcgctgt tgttgcccag gctggagtgc   1320

aatggcacga tcttggctca ctgcaacctc cacttcccag gttctagcga gtctcctccc   1380

tcagcctccc aagtagctgg gattacaggc atgtgccacc atgcccagct aattttgtat   1440

ttttagtaga gacagggttt ctccatgttg gtcaggctgg tctcgaactc ccgacctcag   1500

gtgatccgcc cgcctcggcc tcccaaagtg ctgggattac aggcatgagc cactgcgcca   1560

gcctaaagtg tgttcttacc acctattttt cttcccatag gagttagcca gtgaagggag   1620

aatgtctggt tttctatgct gtcagaaatc tcttttctag gtttgtaaaa ttgaactttt   1680

agtacttcga attatttctc tttaagataa aaatgcatac gatttttaca ctgatcttag   1740

atttttgact tatgaggcca gtggtttaaa caatcattat tgaataccaa gcccaaaagt   1800

ttagttaata caccaattgt aagttctggt ctgaattttg tcaacatatt tagaatgtaa   1860

atggcattat taaaaatgta tctgatttct ctgtgaacag taatatttca tatttttaag   1920

tttaaaaatg ttagtgtaag ccaggcacag tggcattcac ctgtagtgcc aaccactcag   1980

gaggctgaga tgggagacct tttaagcctg agtttgagtc aggcctgggc aacatagatg   2040

tgagcaccta tctctaaaaa tgtaaataaa taaaaatctc aaaaaaatta aaaatctcaa   2100

gtgtaaaaac agttctgtag atagatggta gtgatggtag cacatcaatg tgaaggtatt   2160

taatgccact gaactgtaca cttataacga attaggataa attttatgtt atgtgtattt   2220

actacaattt tttaaaaatc gtatatgtag tttaacaggt gtggtcaata tcaaaactta   2280

ggtatttaat cttgttaaat tatataagca gaaaatgctg gaaaaagtac ctgtcataga   2340

aaaaaataaa cttcctaaat ca                                            2362


<210>  392
<211>  274
<212>  PRT
<213>  Homosapiens

<400>  392

Met Arg Ala Ala Gly Val Gly Leu Val Asp Cys His Cys His Leu Ser 
1               5                   10                  15      


Ala Pro Asp Phe Asp Arg Asp Leu Asp Asp Val Leu Glu Lys Ala Lys 
            20                  25                  30          


Lys Ala Asn Val Val Ala Leu Val Ala Val Ala Glu His Ser Gly Glu 
        35                  40                  45              


Phe Glu Lys Ile Met Gln Leu Ser Glu Arg Tyr Asn Gly Phe Val Leu 
    50                  55                  60                  


Pro Cys Leu Gly Val His Pro Val Gln Gly Leu Pro Pro Glu Asp Gln 
65                  70                  75                  80  


Arg Ser Val Thr Leu Lys Asp Leu Asp Val Ala Leu Pro Ile Ile Glu 
                85                  90                  95      


Asn Tyr Lys Asp Arg Leu Leu Ala Ile Gly Glu Val Gly Leu Asp Phe 
            100                 105                 110         


Ser Pro Arg Phe Ala Gly Thr Gly Glu Gln Lys Glu Glu Gln Arg Gln 
        115                 120                 125             


Val Leu Ile Arg Gln Ile Gln Leu Ala Lys Arg Leu Asn Leu Pro Val 
    130                 135                 140                 


Asn Val His Ser Arg Ser Ala Gly Arg Pro Thr Ile Asn Leu Leu Gln 
145                 150                 155                 160 


Glu Gln Gly Ala Glu Lys Val Leu Leu His Ala Phe Asp Gly Arg Pro 
                165                 170                 175     


Ser Val Ala Met Glu Gly Val Arg Ala Gly Tyr Phe Phe Ser Ile Pro 
            180                 185                 190         


Pro Ser Ile Ile Arg Ser Gly Gln Lys Gln Lys Leu Val Lys Gln Leu 
        195                 200                 205             


Pro Leu Thr Ser Ile Cys Leu Glu Thr Asp Ser Pro Ala Leu Gly Pro 
    210                 215                 220                 


Glu Lys Gln Val Arg Asn Glu Pro Trp Asn Ile Ser Ile Ser Ala Glu 
225                 230                 235                 240 


Tyr Ile Ala Gln Val Lys Gly Ile Ser Val Glu Glu Val Ile Glu Val 
                245                 250                 255     


Thr Thr Gln Asn Ala Leu Lys Leu Phe Pro Lys Leu Arg His Leu Leu 
            260                 265                 270         


Gln Lys 
        


<210>  393
<211>  567
<212>  DNA
<213>  Homosapiens

<400>  393
tcaggacgct gcagctgaaa cgttccggct ccggctctgc tggccggtct aaagcggcag     60

ccgccggggc gcaatgcgag cggctggcgt aggcttggtg gactgtcact gccacctctc    120

cgccccggac tttgaccgcg atttggatga tgtgttggag aaagccaaga aggccaatgt    180

tgtggccctt gtggcagttg ccgaacattc aggagaattt gaaaagatta tgcaactttc    240

agaaaggtat aatgggtttg tcctgccatg cttgggtgtt catccagttc aaggacttcc    300

accagaagac caaagaagtg tcacactaaa ggatttggat gtagctttgc ccattattga    360

gaattataag gatcggttgt tggcaattgg agaggttgga ctagatttct cccccagatt    420

tgctggcact ggtgaacaga aggaagagca aagacaagtc ctaatcagac agatccagtt    480

agccaaaaga ctaaatttgc ctgtgtaggt taattatttt cctatgttaa tagctataga    540

gcaaattaaa taatgatcag agttctc                                        567


<210>  394
<211>  144
<212>  PRT
<213>  Homosapiens

<400>  394

Met Arg Ala Ala Gly Val Gly Leu Val Asp Cys His Cys His Leu Ser 
1               5                   10                  15      


Ala Pro Asp Phe Asp Arg Asp Leu Asp Asp Val Leu Glu Lys Ala Lys 
            20                  25                  30          


Lys Ala Asn Val Val Ala Leu Val Ala Val Ala Glu His Ser Gly Glu 
        35                  40                  45              


Phe Glu Lys Ile Met Gln Leu Ser Glu Arg Tyr Asn Gly Phe Val Leu 
    50                  55                  60                  


Pro Cys Leu Gly Val His Pro Val Gln Gly Leu Pro Pro Glu Asp Gln 
65                  70                  75                  80  


Arg Ser Val Thr Leu Lys Asp Leu Asp Val Ala Leu Pro Ile Ile Glu 
                85                  90                  95      


Asn Tyr Lys Asp Arg Leu Leu Ala Ile Gly Glu Val Gly Leu Asp Phe 
            100                 105                 110         


Ser Pro Arg Phe Ala Gly Thr Gly Glu Gln Lys Glu Glu Gln Arg Gln 
        115                 120                 125             


Val Leu Ile Arg Gln Ile Gln Leu Ala Lys Arg Leu Asn Leu Pro Val 
    130                 135                 140                 


<210>  395
<211>  2246
<212>  DNA
<213>  Homosapiens

<400>  395
tcaggacgct gcagctgaaa cgttccggct ccggctctgc tggccggtct aaagcggcag     60

ccgccggggc gcaatgcgag cggctggcgt aggcttggtg gactgtcact gccacctctc    120

cgccccggac tttgaccgcg atttggatga tgtgttggag aaagccaaga aggccaatgt    180

tgtggccctt gtggcagttg ccgaacattc aggagaattt gaaaagatta tgcaactttc    240

agaaaggtat aatgggtttg tcctgccatg cttgggtgtt catccagttc aaggacttcc    300

accagaagac caaagaagtg tcacactaaa ggatttggat gtagctttgc ccattattga    360

gaattataag gatcggttgt tggcaattgg agaggttgga ctagatttct cccccagatt    420

tgctggcact ggtgaacaga aggaagagca aagacaagtc ctaatcagac agatccagtt    480

agccaaaaga ctaaatttgc ctgtaaatgt gcactcacgc tctgctggaa gacctaccat    540

caacctttta caagagcaag cagaaacttg tgaaacaatt gcctttaact tctatatgct    600

tagaaacaga ttcacctgca ctaggaccag aaaaacaggt acggaatgag ccctggaaca    660

tttctatttc agcagaatat attgcccagg tgaaagggat ctcagtggaa gaagttatag    720

aagtgacgac acagaatgca ttaaaactgt ttcctaagct ccgacacttg ctccagaaat    780

agcttcaaaa ccatccatta caaaatcgaa tcaactgcag ggggcagcat ttgaaaaata    840

gaaatgttct gatgaagaat ctgaactgaa gaagctgttt tatagggtta tagaagattg    900

taattgtaga gaaatatttc tcttagaaat aaaactgggc ttggatcctg aaaccctggg    960

ttctgattct agccttgtgc tgcttttcaa ttagccgagt tctggcagga tattgggaaa   1020

atactgctac ttcttacatt gcccttttat atagaaccac cacctgaact gaaaccattg   1080

ctactgggaa gggtggctcc cacaggaaga gtataagcac tactgtgatg aggatggagt   1140

aagctaaagt atactttttt ttttttttga tggagtttcg ctgttgttgc ccaggctgga   1200

gtgcaatggc acgatcttgg ctcactgcaa cctccacttc ccaggttcta gcgagtctcc   1260

tccctcagcc tcccaagtag ctgggattac aggcatgtgc caccatgccc agctaatttt   1320

gtatttttag tagagacagg gtttctccat gttggtcagg ctggtctcga actcccgacc   1380

tcaggtgatc cgcccgcctc ggcctcccaa agtgctggga ttacaggcat gagccactgc   1440

gccagcctaa agtgtgttct taccacctat ttttcttccc ataggagtta gccagtgaag   1500

ggagaatgtc tggttttcta tgctgtcaga aatctctttt ctaggtttgt aaaattgaac   1560

ttttagtact tcgaattatt tctctttaag ataaaaatgc atacgatttt tacactgatc   1620

ttagattttt gacttatgag gccagtggtt taaacaatca ttattgaata ccaagcccaa   1680

aagtttagtt aatacaccaa ttgtaagttc tggtctgaat tttgtcaaca tatttagaat   1740

gtaaatggca ttattaaaaa tgtatctgat ttctctgtga acagtaatat ttcatatttt   1800

taagtttaaa aatgttagtg taagccaggc acagtggcat tcacctgtag tgccaaccac   1860

tcaggaggct gagatgggag accttttaag cctgagtttg agtcaggcct gggcaacata   1920

gatgtgagca cctatctcta aaaatgtaaa taaataaaaa tctcaaaaaa attaaaaatc   1980

tcaagtgtaa aaacagttct gtagatagat ggtagtgatg gtagcacatc aatgtgaagg   2040

tatttaatgc cactgaactg tacacttata acgaattagg ataaatttta tgttatgtgt   2100

atttactaca attttttaaa aatcgtatat gtagtttaac aggtgtggtc aatatcaaaa   2160

cttaggtatt taatcttgtt aaattatata agcagaaaat gctggaaaaa gtacctgtca   2220

tagaaaaaaa taaacttcct aaatca                                        2246


<210>  396
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  396

Met Arg Ala Ala Gly Val Gly Leu Val Asp Cys His Cys His Leu Ser 
1               5                   10                  15      


Ala Pro Asp Phe Asp Arg Asp Leu Asp Asp Val Leu Glu Lys Ala Lys 
            20                  25                  30          


Lys Ala Asn Val Val Ala Leu Val Ala Val Ala Glu His Ser Gly Glu 
        35                  40                  45              


Phe Glu Lys Ile Met Gln Leu Ser Glu Arg Tyr Asn Gly Phe Val Leu 
    50                  55                  60                  


Pro Cys Leu Gly Val His Pro Val Gln Gly Leu Pro Pro Glu Asp Gln 
65                  70                  75                  80  


Arg Ser Val Thr Leu Lys Asp Leu Asp Val Ala Leu Pro Ile Ile Glu 
                85                  90                  95      


Asn Tyr Lys Asp Arg Leu Leu Ala Ile Gly Glu Val Gly Leu Asp Phe 
            100                 105                 110         


Ser Pro Arg Phe Ala Gly Thr Gly Glu Gln Lys Glu Glu Gln Arg Gln 
        115                 120                 125             


Val Leu Ile Arg Gln Ile Gln Leu Ala Lys Arg Leu Asn Leu Pro Val 
    130                 135                 140                 


Asn Val His Ser Arg Ser Ala Gly Arg Pro Thr Ile Asn Leu Leu Gln 
145                 150                 155                 160 


Glu Gln Ala Glu Thr Cys Glu Thr Ile Ala Phe Asn Phe Tyr Met Leu 
                165                 170                 175     


Arg Asn Arg Phe Thr Cys Thr Arg Thr Arg Lys Thr Gly Thr Glu 
            180                 185                 190     


<210>  397
<211>  2383
<212>  DNA
<213>  Homosapiens

<400>  397
tcaggacgct gcagctgaaa cgttccggct ccggctctgc tggccggtct aaagcggcag     60

ccgccggggc gcaatgcgag cggctggcgt aggcttggtg gactgtcact gccacctctc    120

cgccccggac tttgaccgcg atttggatga tgtgttggag aaagccaaga aggccaatgt    180

tgtggccctt gtggcagttg ccgaacattc aggagaattt gaaaagatta tgcaactttc    240

agaaaggtat aatgggtttg tcctgccatg cttgggtgtt catccagttc aaggacttcc    300

accagaagac caaagaagtg tcacactaaa ggatttggat gtagctttgc ccattattga    360

gaattataag gatcggttgt tggcaattgg agaggttgga ctagatttct cccccagatt    420

tgctggcact ggtgaacaga aggaagagca aagacaagtc ctaatcagac agatccagtt    480

agccaaaaga ctaaatttgc ctgtaaatgt gcactcacgc tctgctggaa gacctaccat    540

caacctttta caagagcaag gtgctgagaa ggtactgctg catgcatttg atggtcggcc    600

atctgtagcc atggaaggag taagagctgg gtacttcttc tcaattcccc cttctatcat    660

aagaagtgga cagctgcttt ctcttttctc taagaagcag aaacttgtga aacaattgcc    720

tttaacttct atatgcttag aaacagattc acctgcacta ggaccagaaa aacaggtacg    780

gaatgagccc tggaacattt ctatttcagc agaatatatt gcccaggtga aagggatctc    840

agtggaagaa gttatagaag tgacgacaca gaatgcatta aaactgtttc ctaagctccg    900

acacttgctc cagaaatagc ttcaaaacca tccattacaa aatcgaatca actgcagggg    960

gcagcatttg aaaaatagaa atgttctgat gaagaatctg aactgaagaa gctgttttat   1020

agggttatag aagattgtaa ttgtagagaa atatttctct tagaaataaa actgggcttg   1080

gatcctgaaa ccctgggttc tgattctagc cttgtgctgc ttttcaatta gccgagttct   1140

ggcaggatat tgggaaaata ctgctacttc ttacattgcc cttttatata gaaccaccac   1200

ctgaactgaa accattgcta ctgggaaggg tggctcccac aggaagagta taagcactac   1260

tgtgatgagg atggagtaag ctaaagtata cttttttttt tttttgatgg agtttcgctg   1320

ttgttgccca ggctggagtg caatggcacg atcttggctc actgcaacct ccacttccca   1380

ggttctagcg agtctcctcc ctcagcctcc caagtagctg ggattacagg catgtgccac   1440

catgcccagc taattttgta tttttagtag agacagggtt tctccatgtt ggtcaggctg   1500

gtctcgaact cccgacctca ggtgatccgc ccgcctcggc ctcccaaagt gctgggatta   1560

caggcatgag ccactgcgcc agcctaaagt gtgttcttac cacctatttt tcttcccata   1620

ggagttagcc agtgaaggga gaatgtctgg ttttctatgc tgtcagaaat ctcttttcta   1680

ggtttgtaaa attgaacttt tagtacttcg aattatttct ctttaagata aaaatgcata   1740

cgatttttac actgatctta gatttttgac ttatgaggcc agtggtttaa acaatcatta   1800

ttgaatacca agcccaaaag tttagttaat acaccaattg taagttctgg tctgaatttt   1860

gtcaacatat ttagaatgta aatggcatta ttaaaaatgt atctgatttc tctgtgaaca   1920

gtaatatttc atatttttaa gtttaaaaat gttagtgtaa gccaggcaca gtggcattca   1980

cctgtagtgc caaccactca ggaggctgag atgggagacc ttttaagcct gagtttgagt   2040

caggcctggg caacatagat gtgagcacct atctctaaaa atgtaaataa ataaaaatct   2100

caaaaaaatt aaaaatctca agtgtaaaaa cagttctgta gatagatggt agtgatggta   2160

gcacatcaat gtgaaggtat ttaatgccac tgaactgtac acttataacg aattaggata   2220

aattttatgt tatgtgtatt tactacaatt ttttaaaaat cgtatatgta gtttaacagg   2280

tgtggtcaat atcaaaactt aggtatttaa tcttgttaaa ttatataagc agaaaatgct   2340

ggaaaaagta cctgtcatag aaaaaaataa acttcctaaa tca                     2383


<210>  398
<211>  281
<212>  PRT
<213>  Homosapiens

<400>  398

Met Arg Ala Ala Gly Val Gly Leu Val Asp Cys His Cys His Leu Ser 
1               5                   10                  15      


Ala Pro Asp Phe Asp Arg Asp Leu Asp Asp Val Leu Glu Lys Ala Lys 
            20                  25                  30          


Lys Ala Asn Val Val Ala Leu Val Ala Val Ala Glu His Ser Gly Glu 
        35                  40                  45              


Phe Glu Lys Ile Met Gln Leu Ser Glu Arg Tyr Asn Gly Phe Val Leu 
    50                  55                  60                  


Pro Cys Leu Gly Val His Pro Val Gln Gly Leu Pro Pro Glu Asp Gln 
65                  70                  75                  80  


Arg Ser Val Thr Leu Lys Asp Leu Asp Val Ala Leu Pro Ile Ile Glu 
                85                  90                  95      


Asn Tyr Lys Asp Arg Leu Leu Ala Ile Gly Glu Val Gly Leu Asp Phe 
            100                 105                 110         


Ser Pro Arg Phe Ala Gly Thr Gly Glu Gln Lys Glu Glu Gln Arg Gln 
        115                 120                 125             


Val Leu Ile Arg Gln Ile Gln Leu Ala Lys Arg Leu Asn Leu Pro Val 
    130                 135                 140                 


Asn Val His Ser Arg Ser Ala Gly Arg Pro Thr Ile Asn Leu Leu Gln 
145                 150                 155                 160 


Glu Gln Gly Ala Glu Lys Val Leu Leu His Ala Phe Asp Gly Arg Pro 
                165                 170                 175     


Ser Val Ala Met Glu Gly Val Arg Ala Gly Tyr Phe Phe Ser Ile Pro 
            180                 185                 190         


Pro Ser Ile Ile Arg Ser Gly Gln Leu Leu Ser Leu Phe Ser Lys Lys 
        195                 200                 205             


Gln Lys Leu Val Lys Gln Leu Pro Leu Thr Ser Ile Cys Leu Glu Thr 
    210                 215                 220                 


Asp Ser Pro Ala Leu Gly Pro Glu Lys Gln Val Arg Asn Glu Pro Trp 
225                 230                 235                 240 


Asn Ile Ser Ile Ser Ala Glu Tyr Ile Ala Gln Val Lys Gly Ile Ser 
                245                 250                 255     


Val Glu Glu Val Ile Glu Val Thr Thr Gln Asn Ala Leu Lys Leu Phe 
            260                 265                 270         


Pro Lys Leu Arg His Leu Leu Gln Lys 
        275                 280     


<210>  399
<211>  537
<212>  DNA
<213>  Homosapiens

<400>  399
tcccagtggg ctaatccaca ccagtggact tgaaacacgc tttgggttgc tgtatggtag     60

tatgctaaag gacagcaaga atcacttgac aattggtttg tgaccataat ggcatctata    120

aacagaacca ttgaaataat gaaaaaacat ggagtaagca aacaacatct cctggaggag    180

ataaacaaaa agcgtgaatc caactgcttg gtggaacgaa gcaatcaagt cagcttactg    240

agagttcaaa agaggcactt cccggatgcc tatcagtcct ttactgatac cacaaccaaa    300

gagcctgttc ccaacagtgg caggagctcc tggatcaagc tgagtctcct tgctcacatg    360

gagagaaagc actttccacc aaaaaataat gccatatttg gataaagtgc atctccagag    420

acacacggaa atacattctc tttgattctt cttcagtgtg tctaaattat ttacaaatta    480

ttaattataa acaaagctaa acaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa       537


<210>  400
<211>  98
<212>  PRT
<213>  Homosapiens

<400>  400

Met Ala Ser Ile Asn Arg Thr Ile Glu Ile Met Lys Lys His Gly Val 
1               5                   10                  15      


Ser Lys Gln His Leu Leu Glu Glu Ile Asn Lys Lys Arg Glu Ser Asn 
            20                  25                  30          


Cys Leu Val Glu Arg Ser Asn Gln Val Ser Leu Leu Arg Val Gln Lys 
        35                  40                  45              


Arg His Phe Pro Asp Ala Tyr Gln Ser Phe Thr Asp Thr Thr Thr Lys 
    50                  55                  60                  


Glu Pro Val Pro Asn Ser Gly Arg Ser Ser Trp Ile Lys Leu Ser Leu 
65                  70                  75                  80  


Leu Ala His Met Glu Arg Lys His Phe Pro Pro Lys Asn Asn Ala Ile 
                85                  90                  95      


Phe Gly 
        


<210>  401
<211>  2008
<212>  DNA
<213>  Homosapiens

<400>  401
gccgcgcggc gcgggggagg agaccttcat ctgttcacgc ggtagcgcgg attgcggttc     60

gcggcgcgcg ccaccgggga aggagcggtg ggccgagggg ttggaggtgg ggccccagga    120

ggacctcggg ctgtgggccg ggagagcgga gtcggggagt ggggcggggg agcgaggtgg    180

cgccggggag cctgggatat ggcgcggcca gacgatgagg agggggcggc ggtggcgccc    240

ggacacccgc tcgcgaaagg atacctcccg ttgccgaggg gcgcgcccgt tgggaaggag    300

agcgtggagc tgcagaacgg gcccaaagcg ggcaccttcc cggtgaatgg ggccccccgg    360

gacagcctcg ctgccgcctc gggagttctg ggcgggcctc agactccact ggccccagaa    420

gaggagaccc aggcccggct gctgcctgcg ggcgcgggag ctgagacccc gggggccgag    480

agcagcccgc tgccccttac ggcgctctcc ccgcggcgct tcgtggtgct cctgatcttc    540

agcctgtact cgctggtcaa cgcctttcag tggatccagt acagcatcat tagcaacgtc    600

ttcgagggct tctacggtgt caccttgctg cacatcgact ggctgtccat ggtgtacatg    660

ctggcctacg tgcccctcat cttcccggcc acctggctgc tggacaccag aggcctgcgg    720

ctcaccgccc tgctgggctc cggcctcaac tgcctgggtg cctggatcaa gtgcggcagt    780

gtgcaacaac atctcttctg ggtcaccatg ttgggccagt gcttgtgctc ggtggcccag    840

gtgttcatcc tgggcttgcc ctcccgcatc gcctcagtgt ggtttgggcc caaagaggtg    900

tccacagctt gtgccaccgc cgtgctgggc aatcagcttg gaactgcagt tggctttttg    960

ctaccaccag ttttagtacc caacacacag aatgacacaa atctcctggc ttgtaatatc   1020

agcaccatgt tttatggaac atcagctgtt gccacacttt tatttatttt aacagcaatt   1080

gccttcaaag aaaaacctcg gtatccacca agtcaggctc aagcagctct tcaagacagt   1140

ccccctgaag agtactccta taagaaatca ataagaaacc tgtttaaaaa cattcctttt   1200

gtccttctgt tgatcactta tggtatcatg actggtgcct tttattcagt ctcaacgtta   1260

ttaaatcaaa tgatattgac atattatgag ggagaagaag tcaatgctgg aaggattggg   1320

ctaacgctag tagtagctgg aatggtgggc tctattcttt gtggcttatg gctggattat   1380

actaaaacat acaaacagac taccctgata gtttatattt tgtcttttat tggaatggtt   1440

atctttactt tcacattgga ccttagatat attatcatcg tgtttgttac tggaggggtg   1500

cttggcttct tcatgactgg ttacctccct ttgggttttg aatttgctgt tgaaatcact   1560

taccctgaat ctgaaggtac ttcatctggt cttcttaatg cttctgcaca gatatttgga   1620

attttgttca cattggctca aggaaagctc acatcagact atggtcctaa ggcagggaac   1680

atttttctct gtgtctggat gtttataggc atcatattaa cagcattaat caagtctgat   1740

ctgcgaagac acaacataaa tataggaatt acaaatgttg atgttaaagc tataccagct   1800

gacagtccca cagaccaaga accaaaaacg gttatgttgt ccaagcagtc agaatcagca   1860

atttgaagag aaaggcaaag ttactgtccc gtagtaattg gggacaatgt gatcatcctt   1920

ggagagagat gtgagcacca aggctgggtt tgtatgtggt gggggaataa acacacttac   1980

ttgaaaatta aaaaaaaaaa aaaaaaaa                                      2008


<210>  402
<211>  555
<212>  PRT
<213>  Homosapiens

<400>  402

Met Ala Arg Pro Asp Asp Glu Glu Gly Ala Ala Val Ala Pro Gly His 
1               5                   10                  15      


Pro Leu Ala Lys Gly Tyr Leu Pro Leu Pro Arg Gly Ala Pro Val Gly 
            20                  25                  30          


Lys Glu Ser Val Glu Leu Gln Asn Gly Pro Lys Ala Gly Thr Phe Pro 
        35                  40                  45              


Val Asn Gly Ala Pro Arg Asp Ser Leu Ala Ala Ala Ser Gly Val Leu 
    50                  55                  60                  


Gly Gly Pro Gln Thr Pro Leu Ala Pro Glu Glu Glu Thr Gln Ala Arg 
65                  70                  75                  80  


Leu Leu Pro Ala Gly Ala Gly Ala Glu Thr Pro Gly Ala Glu Ser Ser 
                85                  90                  95      


Pro Leu Pro Leu Thr Ala Leu Ser Pro Arg Arg Phe Val Val Leu Leu 
            100                 105                 110         


Ile Phe Ser Leu Tyr Ser Leu Val Asn Ala Phe Gln Trp Ile Gln Tyr 
        115                 120                 125             


Ser Ile Ile Ser Asn Val Phe Glu Gly Phe Tyr Gly Val Thr Leu Leu 
    130                 135                 140                 


His Ile Asp Trp Leu Ser Met Val Tyr Met Leu Ala Tyr Val Pro Leu 
145                 150                 155                 160 


Ile Phe Pro Ala Thr Trp Leu Leu Asp Thr Arg Gly Leu Arg Leu Thr 
                165                 170                 175     


Ala Leu Leu Gly Ser Gly Leu Asn Cys Leu Gly Ala Trp Ile Lys Cys 
            180                 185                 190         


Gly Ser Val Gln Gln His Leu Phe Trp Val Thr Met Leu Gly Gln Cys 
        195                 200                 205             


Leu Cys Ser Val Ala Gln Val Phe Ile Leu Gly Leu Pro Ser Arg Ile 
    210                 215                 220                 


Ala Ser Val Trp Phe Gly Pro Lys Glu Val Ser Thr Ala Cys Ala Thr 
225                 230                 235                 240 


Ala Val Leu Gly Asn Gln Leu Gly Thr Ala Val Gly Phe Leu Leu Pro 
                245                 250                 255     


Pro Val Leu Val Pro Asn Thr Gln Asn Asp Thr Asn Leu Leu Ala Cys 
            260                 265                 270         


Asn Ile Ser Thr Met Phe Tyr Gly Thr Ser Ala Val Ala Thr Leu Leu 
        275                 280                 285             


Phe Ile Leu Thr Ala Ile Ala Phe Lys Glu Lys Pro Arg Tyr Pro Pro 
    290                 295                 300                 


Ser Gln Ala Gln Ala Ala Leu Gln Asp Ser Pro Pro Glu Glu Tyr Ser 
305                 310                 315                 320 


Tyr Lys Lys Ser Ile Arg Asn Leu Phe Lys Asn Ile Pro Phe Val Leu 
                325                 330                 335     


Leu Leu Ile Thr Tyr Gly Ile Met Thr Gly Ala Phe Tyr Ser Val Ser 
            340                 345                 350         


Thr Leu Leu Asn Gln Met Ile Leu Thr Tyr Tyr Glu Gly Glu Glu Val 
        355                 360                 365             


Asn Ala Gly Arg Ile Gly Leu Thr Leu Val Val Ala Gly Met Val Gly 
    370                 375                 380                 


Ser Ile Leu Cys Gly Leu Trp Leu Asp Tyr Thr Lys Thr Tyr Lys Gln 
385                 390                 395                 400 


Thr Thr Leu Ile Val Tyr Ile Leu Ser Phe Ile Gly Met Val Ile Phe 
                405                 410                 415     


Thr Phe Thr Leu Asp Leu Arg Tyr Ile Ile Ile Val Phe Val Thr Gly 
            420                 425                 430         


Gly Val Leu Gly Phe Phe Met Thr Gly Tyr Leu Pro Leu Gly Phe Glu 
        435                 440                 445             


Phe Ala Val Glu Ile Thr Tyr Pro Glu Ser Glu Gly Thr Ser Ser Gly 
    450                 455                 460                 


Leu Leu Asn Ala Ser Ala Gln Ile Phe Gly Ile Leu Phe Thr Leu Ala 
465                 470                 475                 480 


Gln Gly Lys Leu Thr Ser Asp Tyr Gly Pro Lys Ala Gly Asn Ile Phe 
                485                 490                 495     


Leu Cys Val Trp Met Phe Ile Gly Ile Ile Leu Thr Ala Leu Ile Lys 
            500                 505                 510         


Ser Asp Leu Arg Arg His Asn Ile Asn Ile Gly Ile Thr Asn Val Asp 
        515                 520                 525             


Val Lys Ala Ile Pro Ala Asp Ser Pro Thr Asp Gln Glu Pro Lys Thr 
    530                 535                 540                 


Val Met Leu Ser Lys Gln Ser Glu Ser Ala Ile 
545                 550                 555 


<210>  403
<211>  3580
<212>  DNA
<213>  Homosapiens

<400>  403
gccccagcag ccccagcccc agccccaggc ccagcagcag cagcagcagc ccctgctctc     60

ccgccgcccg gagaggctct gcagccatga agccaaccgt cccgaggcac cgccggtaag    120

cagggagcct ccgcggagct cccgccgccg ctcccccttg gtgagtcctg ccgcagcgag    180

aggcatggag aaggccgccc ccgcggggcg ctgatcccct cgccgcgccc gcgcgcacac    240

gccccccgcc gccgccgccg ctgccgccgc cgcgcgcccc cagtacctcg ctccccaccc    300

aggccccacc atgaccggct ccgcggccga cactcaccgc tgcccccacc ccaaaggcgc    360

caaaggcacc cggtcccgga gcagccacgc gcggcccgtg agcctcgcca ccagcggggg    420

ctcagaggag gaggacaaag acggcggggt gctgttccac gtcaacaaga gcggcttccc    480

catcgacagc cacacctggg agcgcatgtg gatgcacgtg gccaaggtgc accctaaggg    540

gggagaaatg gtgggcgcca tcaggaacgc cgccttcttg gcaaagcctt caatacccca    600

ggtcccaaac tacaggctgt cgatgacgat cccagactgg ctccaggcga tccagaatta    660

catgaagacc ctacactact taaccaatgg gcagccttcc attgagcggt tccccatcag    720

ctttaaaacc tacttctcag gaaactactt tcaccacgtt gtgctgggga tttactgcaa    780

tggccgctat ggctcattgg gcatgagccg cagggctgag ctgatggaca agccattgac    840

ttttcggact ctgagtgacc tcatctttga ctttgaggac tcttacaaga aatacctgca    900

cacagtcaag aaggtcaaga ttgggctgta cgtcccccat gagcctcata gcttccagcc    960

cattgagtgg aagcagctgg tcctcaacgt ctcaaagatg ctgagggctg acataaggaa   1020

ggagctggag aaatatgcca gggacatgag aatgaagatc ctgaaacctg caagtgccca   1080

ctctccgacc caagtgagaa gccggggaaa atccctgtcc cccagaagga gacaggcaag   1140

ccccccgagg aggctcggcc ggcgagagaa gtcgcctgca ctgcctgaaa agaaggtggc   1200

tgatctgagc actctgaatg aagtgggcta tcaaatccga atttagccaa gccataccgg   1260

ccagcaagag ggtttctgtg gtgcttctct ctgcacttta cccagcatct tcaggaggaa   1320

ctgcaactat ttattaagaa cttgtgaatt ttatttttaa ggattcacct ggaaatagaa   1380

tctgagtggg tggtaaccat tagctttaaa aaattcacta aaaggcacca tgaaaaggct   1440

gaagtaataa gccccactgg ggttgaacta tgtccctcac tcaagatctt aaggataacc   1500

gtaactgaag ttttatattt ttccatttac ctactttctt ttacttgctt tgaacattat   1560

gcctcaccaa tagtaaatgt tcatgaaata atctcttgaa cttttggtat agtaaggtaa   1620

ctctaacagt attactgtct ttttcagcaa taacagaaag caaaaatggg tgggtttttt   1680

ttaagcagtt attacctcag cattttgaca tcagatatgc aaacttaatg gcgttttgtt   1740

tttttatatt ctatttgtat tctttcccca gtatttccca tggggatctc cacaagtttg   1800

gagttttttc ctggtgcaca cacgtgagga gatttaaggt actatatgca agtgttttac   1860

taaaaagcac tgaaattctt ctggcaatac aagaaccatt ttcaggatct tggagttact   1920

tccttcttaa tctttcttaa agcattcact gatgtttttg ttttttcaaa atgaaacaaa   1980

aatatcacat tgagaagcta gtctatgttc tgtcactaac atttaaactt tgcagactct   2040

aacaaaaagc acaagaggtc acgtactatt atacaaattt agcggtactg gatttacctc   2100

tgacattaac acactcaggc agagaccagg agtgatcagc aggtcttcag aaccaaaaaa   2160

cctttctgtt cacatttcat ctgattttta aactgaggca ggctttgatt cttctgaagg   2220

atgccaagaa tcaaactaag ggaggactca ctgttaaaga tgtgttctga tgtcttatat   2280

taagaccaaa tgtgacatga tgtgattatc ttccagtact ttgcttttag gtaccatttc   2340

atgacatttt aggaatgagt attggaaaat ataaagaatt agaaaagcag cacttttttt   2400

ttaatggaaa agtcttcggt ccagtgttac accttatagt gtaattcagt ccctaagcac   2460

agaatgaatg tctggcctgc atatggtagt tacagtgtaa cctctggctg cagaccacac   2520

aggacaaccc taacagccta gtcttgtatg gtgtaaatat caagagtaca gcttcaattt   2580

catttgcttt atcttagcaa caatgccaac tcaggagagc agacggccga tttcagtgaa   2640

gtctggtagt caacagatgt tatttcagtc tcagtgcatc tcctctggct ttctttgact   2700

gaaggtgttt ataggaagga agttaaaaaa aaaaaagctc attgagattc tttaccaatt   2760

ctttacaaga tttctggggg tgacagggaa agcaaaagga cttcaaagca aaagggtgca   2820

caagagctta cttcaccctg aaaatcagta ttattaatga aaagtactgt tttcttaaag   2880

aagtcgaatg tcctttagat gaacaagacc aagtatacat ctccattaga ttaaaatgta   2940

gcacagggtt aaaaattatc agtttaatct ctttaagaac agtattatca gagtttaaaa   3000

tgagttagct ctgtttatct acacacagca aacccattcg cagcctcttg gccacatgta   3060

ttcagatgtt tgaaatagtg aatcatttca ttttcattct aaaacaatac tgacttagcc   3120

atataccttc tgtttgtcaa tctgaaactt gcttacatct aataagtaga cctcttataa   3180

cactgcaacc attctaagag ttggaattta tttttgccaa gtattaagta ctgttacatc   3240

taaaatacag aatgtcaaat ggttgcatag cttgtttccc acaacaagga ggaaaagaac   3300

aggaatacaa actctgtaat atgctgataa agaagcctta gaactgccaa ctggcttgat   3360

ggttcaatta gtaagctaat ttctcccaca cccgctcctt gatttttaga ctaattttcc   3420

caaagcaagg tttagtcaca caaacttgaa agtacattta aaatgttctt agttgtcatc   3480

ctacttttat tgcctatgga atatgctaat ttctaaaaaa aatacgggag aggcaccaaa   3540

cccctaaatt ctagtgcaat aatttaaaaa aaaaaaaaaa                         3580


<210>  404
<211>  311
<212>  PRT
<213>  Homosapiens

<400>  404

Met Thr Gly Ser Ala Ala Asp Thr His Arg Cys Pro His Pro Lys Gly 
1               5                   10                  15      


Ala Lys Gly Thr Arg Ser Arg Ser Ser His Ala Arg Pro Val Ser Leu 
            20                  25                  30          


Ala Thr Ser Gly Gly Ser Glu Glu Glu Asp Lys Asp Gly Gly Val Leu 
        35                  40                  45              


Phe His Val Asn Lys Ser Gly Phe Pro Ile Asp Ser His Thr Trp Glu 
    50                  55                  60                  


Arg Met Trp Met His Val Ala Lys Val His Pro Lys Gly Gly Glu Met 
65                  70                  75                  80  


Val Gly Ala Ile Arg Asn Ala Ala Phe Leu Ala Lys Pro Ser Ile Pro 
                85                  90                  95      


Gln Val Pro Asn Tyr Arg Leu Ser Met Thr Ile Pro Asp Trp Leu Gln 
            100                 105                 110         


Ala Ile Gln Asn Tyr Met Lys Thr Leu His Tyr Leu Thr Asn Gly Gln 
        115                 120                 125             


Pro Ser Ile Glu Arg Phe Pro Ile Ser Phe Lys Thr Tyr Phe Ser Gly 
    130                 135                 140                 


Asn Tyr Phe His His Val Val Leu Gly Ile Tyr Cys Asn Gly Arg Tyr 
145                 150                 155                 160 


Gly Ser Leu Gly Met Ser Arg Arg Ala Glu Leu Met Asp Lys Pro Leu 
                165                 170                 175     


Thr Phe Arg Thr Leu Ser Asp Leu Ile Phe Asp Phe Glu Asp Ser Tyr 
            180                 185                 190         


Lys Lys Tyr Leu His Thr Val Lys Lys Val Lys Ile Gly Leu Tyr Val 
        195                 200                 205             


Pro His Glu Pro His Ser Phe Gln Pro Ile Glu Trp Lys Gln Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Lys Met Leu Arg Ala Asp Ile Arg Lys Glu Leu Glu 
225                 230                 235                 240 


Lys Tyr Ala Arg Asp Met Arg Met Lys Ile Leu Lys Pro Ala Ser Ala 
                245                 250                 255     


His Ser Pro Thr Gln Val Arg Ser Arg Gly Lys Ser Leu Ser Pro Arg 
            260                 265                 270         


Arg Arg Gln Ala Ser Pro Pro Arg Arg Leu Gly Arg Arg Glu Lys Ser 
        275                 280                 285             


Pro Ala Leu Pro Glu Lys Lys Val Ala Asp Leu Ser Thr Leu Asn Glu 
    290                 295                 300                 


Val Gly Tyr Gln Ile Arg Ile 
305                 310     


<210>  405
<211>  4668
<212>  DNA
<213>  Homosapiens

<400>  405
cggcgagact gcacctccca gcatgccttg cagccaggac tggagtcggt acttaagagt     60

gatggggttc cctagatact ttaggccgtc gcatcgatta tagagattga ggtggaaccc    120

ggggcctggg aactggacgc acgcggaggg cgaagatgga agcctggcgc tgtgtgagga    180

agggctacgg ccactgtgtg gtgggaagag gccgataccc catgtttccc catcactcga    240

ggagtctggg cagagactgg actacaccgt gggagaatct gcaaaggtgt tgctggaaca    300

gacatatttc tagttgtatg aggtggcctg gacattactc tcgagctcct tacccatact    360

tcagtagtag gcatttttca ctaaattgga gaccaccctg tttgtttgag tctagaactc    420

agttccagta ctgtaactgg agacctgaca acctgagcca gacatctttg attcatctct    480

ctagttacgt catgaacgct gagggagatg agccttcatc aaaacgaaga aaacaccaag    540

gtgtgataaa gcggaattgg gaatatatat gtagccatga taaagaaaaa acgaagatcc    600

taggagacaa aaatgttgat cccaaatgtg aagacagtga gaacaagttt gacttttcag    660

tgatgtccta taatatactt tcacaagatt tactggaaga taactctcac ctttatagac    720

attgccggcg gccagtatta cactggagtt ttaggtttcc caatattctg aaagaaatta    780

aacattttga tgcagacgta ctttgtttgc aagaagttca agaagatcat tatggagcag    840

agatcaggcc aagtttggaa tcactgggtt atcactgtga atataagatg cggacaggaa    900

ggaaacctga tggctgtgct atttgcttca aacattccaa attttcactc ttgtcagtga    960

acccagtgga attcttccgc cctgatattt ctctgttgga cagagacaat gttggattag   1020

ttttactctt acagcccaaa attccatatg ctgcctgccc tgcaatctgc gtagcaaata   1080

cgcatctgtt gtataatcca aggcgaggtg atattaagct gacgcaattg gcaatgctac   1140

tggcagagat ttccagtgtt gcccaccaga aagatggcag cttctgccct attgttatgt   1200

gtggtgactt taattctgtt cctggttctc cactatatag tttcataaag gaaggaaaat   1260

tgaattatga aggacttccc ataggaaagg tatctggcca ggaacagtct tcacggggac   1320

aaagaatttt atctattcca atttggcccc caaacctagg tatctcacag aactgtgtgt   1380

atgaggtaca gcaggtacca aaagtagaaa agacagacag tgatctgaca caaacacagc   1440

tgaagcaaac agaggtccta gtgacagctg aaaaattgtc ttcaaattta cagcaccatt   1500

tcagtttgtc atctgtttat tcacattact ttcctgacac tggaattcca gaagtgacca   1560

cctgtcattc ccgaagtgcc ataactgtgg attatatttt ctactctgca gaaaaggaag   1620

atgttgctgg gcacccagga gctgaagttg ctttggttgg tggcttgaaa cttctagcta   1680

gactgtcact tcttacagaa caagacttat ggactgttaa tggacttcca aacgaaaata   1740

actcttcaga tcatctgcct ttattggcaa agttcagact tgagctctga ctctctttga   1800

tcacatacta attttctttc caatttgtat tgtttttcaa agaatgtaaa gttcttaagt   1860

gtatgcatgt tgtttatttt tgcactgtgg agattctgaa gcggttatgt tagatgcttt   1920

gaaactccat atcagaagaa ataactttat aacaattttt tttaataatg aaaaatattt   1980

tcgtgacaag tgagctctaa attctcttta ttgtaaaaga gatgtaaagg ttttatattc   2040

taaatcctag taaaattgac agtgattttt aaatataatg catcttcctt tgtctgctta   2100

gtaaaaaatt tcatttcata attttggcaa gctctgtagt ggatccaaag tatctttgag   2160

ttcttgcaaa ctacaagttg tttcctttcc agaaggcttg atttcattag gagacccctc   2220

tattgagttc taaatagttt atcttagaaa gccttgggtc attcacaggt atccaaccag   2280

ccattgttta gtttgttttt gaaggggttt gataatgctt tttaagttgt acagaatgct   2340

taatccatct tattactgtc ctgagccatg taatatgcct gcatcgtgtt ggggaaatgt   2400

ttgggaaata taagccagca taacgtgtaa agctcactct ttcaccctgg aacagacaag   2460

aggtgggctt aatagaggca gagactgggg atataccttt gtttccctag catttttatt   2520

tatttatttt tattttattt tattttttga gatggagttt cactcttgtt gcccaggctg   2580

ggggtgcaat ggcgcaatct ttgctcactg caacccctgc ctcccgggct caagcgattc   2640

tcctgcctca gcctctcgag tagctgggat tacaggcatg cgtcaccact cccagctaat   2700

tttgtatttt cagtagagac agggtttccc catgttggtt aggctggtct cgaactccca   2760

acctcaggtg atccgcccac ctcagctctc aaagtgctgg gattacaggc gggagccact   2820

gcacatggca gcatttttta aaaattcagt tttaagatct ctggtttagg ggagagattt   2880

tattttactg aaccagttct atagaaattt attttattag gaaatttgtc tttggaacaa   2940

agtggcagct ataaaattat ttttgttaag cctcagaaat atgaggaagc ctgtaaaact   3000

ctagtgggga gatattaact tggagaccta atgctctgta aatagtcatt taaactgttg   3060

gttttagtgg ttttgtttct aaaatgtttt cttttaccgt gatgcaccag tatgagatgg   3120

tgctgacact ttctatgaag tggttatgag caggtttaat aaatcctcta tacaagtgtt   3180

tgaatcaatt ttaaaacata aaaagtggaa atttcctttt ttgtagacag taggaacaag   3240

gaattatatg catttttact aagtagtaat tttacactga attgtaaatg tttttacagt   3300

gagttttatt aatagaatgc ttcaccttaa attggaaaac aataatagtc ttggactaag   3360

tctttgtact aaagcatttg ctataattat ttttaaaaaa acaaacagat gaaaacctca   3420

gagaaggcat gtggattata agatttgtct agtaaaaatt gtaattgaat atgtttaaat   3480

atttaatttc tcattttggg gggtttttat ttttttattt tttagatggt gtctcacgct   3540

atcgcccagg ctggagtgca gtggcgcgaa ctcggctcac tgcaacctcc gcctcctggg   3600

ttcaagcaat tctccttcct cagcctccca agtagctggg attacaggca tgcaccacca   3660

tgcccagcta atttttgtat ttttagtaga gatggaattt tgccatgttg gccaggctgg   3720

tcttgaactc ctgacctcag gggtgatcca cccgcctcgg gctcccaaag tgctgtgatt   3780

acaggcatga gccaccatgc ctggcctttg gggggatttt aattacagta ttaattatag   3840

ttctaggatt tcccacattt tatagtagta gtttgcagga tattatgtgc cctaattagc   3900

agatatagac attatcaaat tataatgata gtataattat ccctttttaa tattggggaa   3960

agaaaaatga aaattcatta gttaattact gctttgtgtt gtgtgaattt attaacaaat   4020

aacattatta catataggtc attgttaaca aacaaacatc cctgaaaacc tctgtgaaaa   4080

tttaattttt tatatcctga ttaatatatt gtgactttag gcccattttt catgtgcttc   4140

actttgatag agttaatcca taaaattgct ctttacttta gcttatcaaa tgaagtatta   4200

ttttgtggac tggaggccaa aaagtcaatg tgagcttctc acaggttttt aaagctccac   4260

taaaaataat tatccacttg tctttacttt tgttgaccag aatagttggt aactctgcca   4320

gagcctgtac ttacctgcca aaaacaatta aatctggtta atgcctgaaa ccaaatctct   4380

cagtctcaag tgttatacta tccaagtttt aaatggaaag gtaaactgtg gagtaatgaa   4440

attttggttt tactgtacct tttgctatca agataatatt catgtttgaa atcttgtctt   4500

tatttggaat ttagttactg tctgctttta acctttgctt tcctaaagaa agtttgagat   4560

ccagagagtt caagggattg gggaaagaga ggcgtcaagt catttgcact ttgtacctgt   4620

aagttaggta ataaactatt atactcgtaa aaaaaaaaaa aaaaaaaa                4668


<210>  406
<211>  544
<212>  PRT
<213>  Homosapiens

<400>  406

Met Glu Ala Trp Arg Cys Val Arg Lys Gly Tyr Gly His Cys Val Val 
1               5                   10                  15      


Gly Arg Gly Arg Tyr Pro Met Phe Pro His His Ser Arg Ser Leu Gly 
            20                  25                  30          


Arg Asp Trp Thr Thr Pro Trp Glu Asn Leu Gln Arg Cys Cys Trp Asn 
        35                  40                  45              


Arg His Ile Ser Ser Cys Met Arg Trp Pro Gly His Tyr Ser Arg Ala 
    50                  55                  60                  


Pro Tyr Pro Tyr Phe Ser Ser Arg His Phe Ser Leu Asn Trp Arg Pro 
65                  70                  75                  80  


Pro Cys Leu Phe Glu Ser Arg Thr Gln Phe Gln Tyr Cys Asn Trp Arg 
                85                  90                  95      


Pro Asp Asn Leu Ser Gln Thr Ser Leu Ile His Leu Ser Ser Tyr Val 
            100                 105                 110         


Met Asn Ala Glu Gly Asp Glu Pro Ser Ser Lys Arg Arg Lys His Gln 
        115                 120                 125             


Gly Val Ile Lys Arg Asn Trp Glu Tyr Ile Cys Ser His Asp Lys Glu 
    130                 135                 140                 


Lys Thr Lys Ile Leu Gly Asp Lys Asn Val Asp Pro Lys Cys Glu Asp 
145                 150                 155                 160 


Ser Glu Asn Lys Phe Asp Phe Ser Val Met Ser Tyr Asn Ile Leu Ser 
                165                 170                 175     


Gln Asp Leu Leu Glu Asp Asn Ser His Leu Tyr Arg His Cys Arg Arg 
            180                 185                 190         


Pro Val Leu His Trp Ser Phe Arg Phe Pro Asn Ile Leu Lys Glu Ile 
        195                 200                 205             


Lys His Phe Asp Ala Asp Val Leu Cys Leu Gln Glu Val Gln Glu Asp 
    210                 215                 220                 


His Tyr Gly Ala Glu Ile Arg Pro Ser Leu Glu Ser Leu Gly Tyr His 
225                 230                 235                 240 


Cys Glu Tyr Lys Met Arg Thr Gly Arg Lys Pro Asp Gly Cys Ala Ile 
                245                 250                 255     


Cys Phe Lys His Ser Lys Phe Ser Leu Leu Ser Val Asn Pro Val Glu 
            260                 265                 270         


Phe Phe Arg Pro Asp Ile Ser Leu Leu Asp Arg Asp Asn Val Gly Leu 
        275                 280                 285             


Val Leu Leu Leu Gln Pro Lys Ile Pro Tyr Ala Ala Cys Pro Ala Ile 
    290                 295                 300                 


Cys Val Ala Asn Thr His Leu Leu Tyr Asn Pro Arg Arg Gly Asp Ile 
305                 310                 315                 320 


Lys Leu Thr Gln Leu Ala Met Leu Leu Ala Glu Ile Ser Ser Val Ala 
                325                 330                 335     


His Gln Lys Asp Gly Ser Phe Cys Pro Ile Val Met Cys Gly Asp Phe 
            340                 345                 350         


Asn Ser Val Pro Gly Ser Pro Leu Tyr Ser Phe Ile Lys Glu Gly Lys 
        355                 360                 365             


Leu Asn Tyr Glu Gly Leu Pro Ile Gly Lys Val Ser Gly Gln Glu Gln 
    370                 375                 380                 


Ser Ser Arg Gly Gln Arg Ile Leu Ser Ile Pro Ile Trp Pro Pro Asn 
385                 390                 395                 400 


Leu Gly Ile Ser Gln Asn Cys Val Tyr Glu Val Gln Gln Val Pro Lys 
                405                 410                 415     


Val Glu Lys Thr Asp Ser Asp Leu Thr Gln Thr Gln Leu Lys Gln Thr 
            420                 425                 430         


Glu Val Leu Val Thr Ala Glu Lys Leu Ser Ser Asn Leu Gln His His 
        435                 440                 445             


Phe Ser Leu Ser Ser Val Tyr Ser His Tyr Phe Pro Asp Thr Gly Ile 
    450                 455                 460                 


Pro Glu Val Thr Thr Cys His Ser Arg Ser Ala Ile Thr Val Asp Tyr 
465                 470                 475                 480 


Ile Phe Tyr Ser Ala Glu Lys Glu Asp Val Ala Gly His Pro Gly Ala 
                485                 490                 495     


Glu Val Ala Leu Val Gly Gly Leu Lys Leu Leu Ala Arg Leu Ser Leu 
            500                 505                 510         


Leu Thr Glu Gln Asp Leu Trp Thr Val Asn Gly Leu Pro Asn Glu Asn 
        515                 520                 525             


Asn Ser Ser Asp His Leu Pro Leu Leu Ala Lys Phe Arg Leu Glu Leu 
    530                 535                 540                 


<210>  407
<211>  4196
<212>  DNA
<213>  Homosapiens

<400>  407
gctgtgcagc tgaggcgccg ccgtggagcc gccttggagc caccgccccc gatcgccttc     60

gccgctgcgt tggggaacct ggaccgcgcg gcgccgggtt tccctcatga tcccgggcgg    120

gtggcggcgg cggcagaggc ggcgggagga tgacctctta ccgggagcgg agtgccgacc    180

tggcccgttt ctacactgtc accgagcccc agcgacaccc gaggggctac acagtatata    240

aggtcaccgc ccgggttgtt tcacgaagaa atccagagga tgtccaggag ataattgtat    300

ggaagagata cagtgatttt aagaaactac acaaagaact atggcaaatt cacaaaaact    360

tattccgaca ttcagagttg tttcctccat ttgctaaagg aatagtgttt gggcgatttg    420

atgaaactgt tatcgaagag agaagacaat gtgctgaaga cctgctacag ttctctgcca    480

atattcctgc tctttacaat agtaaacagc ttgaagactt tttcaagggt ggaataatta    540

atgatagttc tgaattaatt ggtcctgctg aagctcactc agattccctc attgatacct    600

ttcctgagtg tagtacggaa ggcttctcca gtgacagtga tctggtatct cttactgttg    660

atgtggattc tcttgctgag ttagatgatg gaatggcttc caatcaaaat tctcccatta    720

gaacttttgg tctcaatctt tcttcggatt cttcagcact aggggctgtt gcttctgaca    780

gtgaacagag caaaacagaa gaagaacggg aaagtcgtag cctctttcct ggcagtttaa    840

agccgaagct tggcaagaga gattatttgg agaaagcagg agaattaata aagctggctt    900

taaaaaagga agaagaagac gactatgaag ctgcttctga tttttatagg aagggagttg    960

atttactcct agaaggtgtt caaggagagt caagccctac ccgtcgagaa gctgtgaaga   1020

gaagaacagc cgagtacctc atgcgggcag aaagtatctc tagtctttat gggaaacctc   1080

agcttgatga tgtatctcag cctccaggat cactaagttc aaggcccctt tggaacctaa   1140

ggagccctgc cgaggagctg aaggccttca gagtccttgg ggtgattgac aaggttttac   1200

ttgtaatgga cacaaggaca gaacagactt tcattttaaa aggtctaagg aaaagcagtg   1260

aatacagcag gaacagaaag accatcatcc cccgctgtgt gcccaacatg gtgtgtctgc   1320

ataagtacat catctctgag gagtcagtat ttcttgtgct gcagcatgcg gaaggtggca   1380

aactgtggtc atatatcagt aaatttctaa acagaagtcc tgaagaaagc tttgacatca   1440

aggaagtgaa aaaacctaca cttgcaaaag ttcacctgca gcagccaact tctagtcctc   1500

aggacagcag tagctttgaa tccagaggaa gtgatggtgg aagcatgctt aaagctctgc   1560

ctttgaagag tagtcttact ccaagttctc aagatgacag caaccaggaa gatgatggcc   1620

aagatagctc tccaaagtgg ccagattctg gttcaagttc agaagaagaa tgtactacta   1680

gttatttaac attatgcaat gaatatgggc aagaaaagat tgaaccaggg tctttgaatg   1740

aggagccctt catgaagact gaagggaatg gtgttgatac aaaagctatt aaaagcttcc   1800

cagcacacct tgctgctgac agtgacagcc ccagcacaca gctgagagct cacgagctga   1860

agttcttccc caacgatgac ccagaagcag ttagttctcc aagaacatca gattccctca   1920

gtagatcaaa aaatagcccc atggaattct ttaggataga cagtaaggat agcgcaagtg   1980

aactcctggg acttgacttt ggagaaaaat tgtatagtct aaaatcagaa cctttgaaac   2040

cattctttac tcttccagat ggagacagtg cttctaggag ttttaatact agtgaaagca   2100

aggtagagtt taaagctcag gacaccatta gcaggggctc agatgactca gtgccagtta   2160

tttcatttaa agatgctgct tttgatgatg tcagtggtac tgatgaagga agacctgatc   2220

ttcttgtaaa tttacctggt gaattggagt caacaagaga agctgcagca atgggaccta   2280

ctaagtttac acaaactaat atagggataa tagaaaataa actcttggaa gcccctgatg   2340

ttttatgcct caggcttagt actgaacaat gccaagcaca tgaggagaaa ggcatagagg   2400

aactgagtga tccctctggg cccaaatcct atagtataac agagaaacac tatgcacagg   2460

aggatcccag gatgttattt gtagcagctg ttgatcatag tagttcagga gatatgtctt   2520

tgttacccag ctcagatcct aagtttcaag gacttggagt ggttgagtca gcagtaactg   2580

caaacaacac agaagaaagc ttattccgta tttgtagtcc actctcaggt gctaatgaat   2640

atattgcaag cacagacact ttaaaaacag aagaagtatt gctgtttaca gatcagactg   2700

atgatttggc taaagaggaa ccaacttctt tattccagag agactctgag actaagggtg   2760

aaagtggttt agtgctagaa ggagacaagg aaatacatca gatttttgag gaccttgata   2820

aaaaattagc actagcctcc aggttttaca tcccagaggg ctgcattcaa agatgggcag   2880

ctgaaatggt ggtagccctt gatgctttac atagagaggg aattgtgtgc cgcgatttga   2940

acccaaacaa catcttattg aatgatagag gacacattca gctaacgtat tttagcaggt   3000

ggagtgaggt tgaagattcc tgtgacagcg atgccataga gagaatgtac tgtgccccag   3060

aggttggagc aatcactgaa gaaactgaag cctgtgattg gtggagtttg ggtgctgtcc   3120

tctttgaact tctcactggc aagactctgg ttgaatgcca tccagcagga ataaatactc   3180

acactacttt gaacatgcca gaatgtgtct ctgaagaggc tcgctcactc attcaacagc   3240

tcttgcagtt caatcctctg gaacgacttg gtgctggagt tgctggtgtt gaagatatca   3300

aatctcatcc attttttacc cctgtggatt gggcagaact gatgagatga acgtaatgca   3360

gggttatctt cacacattct gatcttctct gtgacaggca tctccagcac tgaggcacct   3420

ctgactcaca gttacttatg gagcaccaaa gcatttggat aaagaccgtt ataggaaatg   3480

ggggggaaat ggctaaaaga gaacaattcg tttacaatta caagatatta gctaattgtg   3540

ccaggggctg ttatatacat atatacacaa ccaaggtgtg atctgaattt aatccacatt   3600

tggtgttgca gatgagttgt aaagccaact gaaagagttc cttcaagaag ttcctctgat   3660

aggaagctag aagtgtagaa tgaagtttta cttgacagaa ggacctttac atggcagcta   3720

acagtgcttt ttgctgacca ggattggttt atatgattaa attaatattt gcttaataat   3780

acactaaaag tatatgaaca atgtcatcaa tgaaacttaa aagcgagaaa aaagaatata   3840

cacataattt ctgacggaaa acctgtaccc tgatgctgta taatgtatgt tgaatgtggt   3900

cccagattat ttctgtaaga agacactcca tgttgtcagc tttgtactct ttgttgatac   3960

tgcttattta gagaagggtt catataaaca ctcactctgt gtcttcaaca gcatctttct   4020

ttccccatct ttctattttc tgcaccctct gcttgttccc tcatattctg ttcttccgac   4080

tcctgctaac acacatgcaa caaaaaaggg aagggagtgc ttatttccct ttgtgtaagg   4140

actaagaaat catgatatca aataaacatg gtgaaacatt aaaaaaaaaa aaaaaa       4196


<210>  408
<211>  1066
<212>  PRT
<213>  Homosapiens

<400>  408

Met Thr Ser Tyr Arg Glu Arg Ser Ala Asp Leu Ala Arg Phe Tyr Thr 
1               5                   10                  15      


Val Thr Glu Pro Gln Arg His Pro Arg Gly Tyr Thr Val Tyr Lys Val 
            20                  25                  30          


Thr Ala Arg Val Val Ser Arg Arg Asn Pro Glu Asp Val Gln Glu Ile 
        35                  40                  45              


Ile Val Trp Lys Arg Tyr Ser Asp Phe Lys Lys Leu His Lys Glu Leu 
    50                  55                  60                  


Trp Gln Ile His Lys Asn Leu Phe Arg His Ser Glu Leu Phe Pro Pro 
65                  70                  75                  80  


Phe Ala Lys Gly Ile Val Phe Gly Arg Phe Asp Glu Thr Val Ile Glu 
                85                  90                  95      


Glu Arg Arg Gln Cys Ala Glu Asp Leu Leu Gln Phe Ser Ala Asn Ile 
            100                 105                 110         


Pro Ala Leu Tyr Asn Ser Lys Gln Leu Glu Asp Phe Phe Lys Gly Gly 
        115                 120                 125             


Ile Ile Asn Asp Ser Ser Glu Leu Ile Gly Pro Ala Glu Ala His Ser 
    130                 135                 140                 


Asp Ser Leu Ile Asp Thr Phe Pro Glu Cys Ser Thr Glu Gly Phe Ser 
145                 150                 155                 160 


Ser Asp Ser Asp Leu Val Ser Leu Thr Val Asp Val Asp Ser Leu Ala 
                165                 170                 175     


Glu Leu Asp Asp Gly Met Ala Ser Asn Gln Asn Ser Pro Ile Arg Thr 
            180                 185                 190         


Phe Gly Leu Asn Leu Ser Ser Asp Ser Ser Ala Leu Gly Ala Val Ala 
        195                 200                 205             


Ser Asp Ser Glu Gln Ser Lys Thr Glu Glu Glu Arg Glu Ser Arg Ser 
    210                 215                 220                 


Leu Phe Pro Gly Ser Leu Lys Pro Lys Leu Gly Lys Arg Asp Tyr Leu 
225                 230                 235                 240 


Glu Lys Ala Gly Glu Leu Ile Lys Leu Ala Leu Lys Lys Glu Glu Glu 
                245                 250                 255     


Asp Asp Tyr Glu Ala Ala Ser Asp Phe Tyr Arg Lys Gly Val Asp Leu 
            260                 265                 270         


Leu Leu Glu Gly Val Gln Gly Glu Ser Ser Pro Thr Arg Arg Glu Ala 
        275                 280                 285             


Val Lys Arg Arg Thr Ala Glu Tyr Leu Met Arg Ala Glu Ser Ile Ser 
    290                 295                 300                 


Ser Leu Tyr Gly Lys Pro Gln Leu Asp Asp Val Ser Gln Pro Pro Gly 
305                 310                 315                 320 


Ser Leu Ser Ser Arg Pro Leu Trp Asn Leu Arg Ser Pro Ala Glu Glu 
                325                 330                 335     


Leu Lys Ala Phe Arg Val Leu Gly Val Ile Asp Lys Val Leu Leu Val 
            340                 345                 350         


Met Asp Thr Arg Thr Glu Gln Thr Phe Ile Leu Lys Gly Leu Arg Lys 
        355                 360                 365             


Ser Ser Glu Tyr Ser Arg Asn Arg Lys Thr Ile Ile Pro Arg Cys Val 
    370                 375                 380                 


Pro Asn Met Val Cys Leu His Lys Tyr Ile Ile Ser Glu Glu Ser Val 
385                 390                 395                 400 


Phe Leu Val Leu Gln His Ala Glu Gly Gly Lys Leu Trp Ser Tyr Ile 
                405                 410                 415     


Ser Lys Phe Leu Asn Arg Ser Pro Glu Glu Ser Phe Asp Ile Lys Glu 
            420                 425                 430         


Val Lys Lys Pro Thr Leu Ala Lys Val His Leu Gln Gln Pro Thr Ser 
        435                 440                 445             


Ser Pro Gln Asp Ser Ser Ser Phe Glu Ser Arg Gly Ser Asp Gly Gly 
    450                 455                 460                 


Ser Met Leu Lys Ala Leu Pro Leu Lys Ser Ser Leu Thr Pro Ser Ser 
465                 470                 475                 480 


Gln Asp Asp Ser Asn Gln Glu Asp Asp Gly Gln Asp Ser Ser Pro Lys 
                485                 490                 495     


Trp Pro Asp Ser Gly Ser Ser Ser Glu Glu Glu Cys Thr Thr Ser Tyr 
            500                 505                 510         


Leu Thr Leu Cys Asn Glu Tyr Gly Gln Glu Lys Ile Glu Pro Gly Ser 
        515                 520                 525             


Leu Asn Glu Glu Pro Phe Met Lys Thr Glu Gly Asn Gly Val Asp Thr 
    530                 535                 540                 


Lys Ala Ile Lys Ser Phe Pro Ala His Leu Ala Ala Asp Ser Asp Ser 
545                 550                 555                 560 


Pro Ser Thr Gln Leu Arg Ala His Glu Leu Lys Phe Phe Pro Asn Asp 
                565                 570                 575     


Asp Pro Glu Ala Val Ser Ser Pro Arg Thr Ser Asp Ser Leu Ser Arg 
            580                 585                 590         


Ser Lys Asn Ser Pro Met Glu Phe Phe Arg Ile Asp Ser Lys Asp Ser 
        595                 600                 605             


Ala Ser Glu Leu Leu Gly Leu Asp Phe Gly Glu Lys Leu Tyr Ser Leu 
    610                 615                 620                 


Lys Ser Glu Pro Leu Lys Pro Phe Phe Thr Leu Pro Asp Gly Asp Ser 
625                 630                 635                 640 


Ala Ser Arg Ser Phe Asn Thr Ser Glu Ser Lys Val Glu Phe Lys Ala 
                645                 650                 655     


Gln Asp Thr Ile Ser Arg Gly Ser Asp Asp Ser Val Pro Val Ile Ser 
            660                 665                 670         


Phe Lys Asp Ala Ala Phe Asp Asp Val Ser Gly Thr Asp Glu Gly Arg 
        675                 680                 685             


Pro Asp Leu Leu Val Asn Leu Pro Gly Glu Leu Glu Ser Thr Arg Glu 
    690                 695                 700                 


Ala Ala Ala Met Gly Pro Thr Lys Phe Thr Gln Thr Asn Ile Gly Ile 
705                 710                 715                 720 


Ile Glu Asn Lys Leu Leu Glu Ala Pro Asp Val Leu Cys Leu Arg Leu 
                725                 730                 735     


Ser Thr Glu Gln Cys Gln Ala His Glu Glu Lys Gly Ile Glu Glu Leu 
            740                 745                 750         


Ser Asp Pro Ser Gly Pro Lys Ser Tyr Ser Ile Thr Glu Lys His Tyr 
        755                 760                 765             


Ala Gln Glu Asp Pro Arg Met Leu Phe Val Ala Ala Val Asp His Ser 
    770                 775                 780                 


Ser Ser Gly Asp Met Ser Leu Leu Pro Ser Ser Asp Pro Lys Phe Gln 
785                 790                 795                 800 


Gly Leu Gly Val Val Glu Ser Ala Val Thr Ala Asn Asn Thr Glu Glu 
                805                 810                 815     


Ser Leu Phe Arg Ile Cys Ser Pro Leu Ser Gly Ala Asn Glu Tyr Ile 
            820                 825                 830         


Ala Ser Thr Asp Thr Leu Lys Thr Glu Glu Val Leu Leu Phe Thr Asp 
        835                 840                 845             


Gln Thr Asp Asp Leu Ala Lys Glu Glu Pro Thr Ser Leu Phe Gln Arg 
    850                 855                 860                 


Asp Ser Glu Thr Lys Gly Glu Ser Gly Leu Val Leu Glu Gly Asp Lys 
865                 870                 875                 880 


Glu Ile His Gln Ile Phe Glu Asp Leu Asp Lys Lys Leu Ala Leu Ala 
                885                 890                 895     


Ser Arg Phe Tyr Ile Pro Glu Gly Cys Ile Gln Arg Trp Ala Ala Glu 
            900                 905                 910         


Met Val Val Ala Leu Asp Ala Leu His Arg Glu Gly Ile Val Cys Arg 
        915                 920                 925             


Asp Leu Asn Pro Asn Asn Ile Leu Leu Asn Asp Arg Gly His Ile Gln 
    930                 935                 940                 


Leu Thr Tyr Phe Ser Arg Trp Ser Glu Val Glu Asp Ser Cys Asp Ser 
945                 950                 955                 960 


Asp Ala Ile Glu Arg Met Tyr Cys Ala Pro Glu Val Gly Ala Ile Thr 
                965                 970                 975     


Glu Glu Thr Glu Ala Cys Asp Trp Trp Ser Leu Gly Ala Val Leu Phe 
            980                 985                 990         


Glu Leu Leu Thr Gly Lys Thr Leu  Val Glu Cys His Pro  Ala Gly Ile 
        995                 1000                 1005             


Asn Thr  His Thr Thr Leu Asn  Met Pro Glu Cys Val  Ser Glu Glu 
    1010                 1015                 1020             


Ala Arg  Ser Leu Ile Gln Gln  Leu Leu Gln Phe Asn  Pro Leu Glu 
    1025                 1030                 1035             


Arg Leu  Gly Ala Gly Val Ala  Gly Val Glu Asp Ile  Lys Ser His 
    1040                 1045                 1050             


Pro Phe  Phe Thr Pro Val Asp  Trp Ala Glu Leu Met  Arg 
    1055                 1060                 1065     


<210>  409
<211>  6332
<212>  DNA
<213>  Homosapiens

<400>  409
tgtttgctct gcagaatact ttacctgggc acccaagtct tccttccagc attcctgctg     60

ctacagccta tttgctgagt aaccaggggt tacagcagcg ttgccaggca acgagggaca    120

gcggtcctgt tgaagagcca tttgtcacac tgaggggact ggttgaaatg caataaagaa    180

atgataccag cagctactca tgtcttcgcc attgctaaga acgtcgttgg tattacctta    240

ctctgagaac gtgtctgcag tttccagaaa atggagtatc gcaacatcac ttaaagtacc    300

ctgcttcaaa gtattgctgg caagtggcgt gggcctgatt atttatttag aaatgcttta    360

tcaggaggag aatgcttttt tgtaaacatg aattgcccag ttctttcatt gggctctggc    420

ttcttgtttc aggtcattga aatgttgatc tttgcctatt ttgcttcaat atccttgact    480

gagtcacgag gtcttttccc aaggctggag aacgtgggag ctttcaagaa agtttccatc    540

gtgccaaccc aagcagtatg tggactccca gaccgaagca ctttttgtca cagctctgct    600

gctgctgaaa gtattcagtt ctgtacccag cggttttgta ttcaggattg cccatacaga    660

tcttcacacc ctacctacac tgcccttttc tcagcaggcc tcagtagctg catcacacca    720

gacaagaatg atctgcatcc taacgcccat agcaattctg caagttttat ttttggaaat    780

cacaagagct gcttttcttc tcctccttct ccaaagctga tggcatcatt taccttagct    840

gtatggctga aacctgagca acaaggtgta atgtgtgtta tagaaaagac agtagatggg    900

cagattgtgt tcaaacttac aatatctgag aaagagacca tgttttatta tcgcacagta    960

aatggtttgc aacctccaat aaaagtaatg acactgggga gaattcttgt gaagaaatgg   1020

attcatctta gtgtgcaggt gcatcagaca aaaatcagct tctttatcaa tggcgtggag   1080

aaggatcata cacctttcaa tgcaagaact ctaagtggtt caattacaga ttttgcatct   1140

ggtactgtgc aaataggaca gagtttaaat ggtttagagc agtttgtcgg aagaatgcaa   1200

gattttcgat tataccaagt ggcacttaca aacagagaga ttctggaagt cttctctgga   1260

gatcttctca gattgcatgc ccaatcacat tgccgttgcc ctggcagcca cccgcgggtc   1320

caccctttgg cacagcggta ctgcattcct aatgatgcag gagacacagc tgataataga   1380

gtgtcacggt tgaatcctga agcccatcct ctctcttttg tcaatgataa tgatgttggt   1440

acttcatggg tttcaaatgt gtttacaaac attacacagc ttaatcaagg agtgactatt   1500

tcagttgatt tggaaaatgg acagtatcag gtgttttata ttatcattca gttctttagt   1560

ccacaaccaa cggaaataag gattcaaagg aagaaggaaa atagtttaga ttgggaggac   1620

tggcaatatt ttgccaggaa ttgtggtgct tttggaatga aaaacaatgg agatttggaa   1680

aaacctgatt ctgtcaactg tcttcagctt tccaatttta ctccatattc ccgtggcaat   1740

gtcacattta gcatcctgac acctggacca aattatcgtc ctggatacaa taacttctat   1800

aataccccat ctcttcaaga gttcgtaaaa gccacgcaaa taaggtttca ttttcatggg   1860

cagtactata caactgagac tgctgttaac ctcagacaca gatattatgc agtggacgaa   1920

atcaccatta gtgggagatg tcagtgccat ggtcatgccg ataactgcga cacaacaagc   1980

cagccatata gatgcctctg ctcccaggag agcttcactg aaggacttca ttgtgatcgc   2040

tgcttgcctc tttataatga caagcctttc cgccaaggtg atcaagttta cgctttcaat   2100

tgtaaacctt gtcaatgcaa cagccattcc aaaagctgcc attacaacat ctctgtagac   2160

ccatttcctt ttgagcactt cagaggggga ggaggagttt gtgatgattg tgagcataac   2220

actacaggaa ggaactgtga gctgtgcaag gattactttt tccgacaagt tggtgcagat   2280

ccttcggcca tagatgtttg caaaccctgt gactgtgata cagttggcac tagaaatggt   2340

agcattcttt gtgatcagat tggaggacag tgtaattgta agagacacgt gtctggcagg   2400

cagtgcaatc agtgccagaa tggattctac aatctacaag agttggatcc tgatggctgc   2460

agtccctgta actgcaatac ctctgggaca gtggatggag atattacctg tcaccaaaat   2520

tcaggccagt gcaagtgcaa agcaaacgtt attgggctta ggtgtgatca ttgcaatttt   2580

ggatttaaat ttctccgaag ctttaatgat gttggatgtg agccctgcca gtgtaacctc   2640

catggctcag tgaacaaatt ctgcaatcct cactctgggc agtgtgagtg caaaaaagaa   2700

gccaaaggac ttcagtgtga cacctgcaga gaaaactttt atgggttaga tgtcaccaat   2760

tgtaaggcct gtgactgtga cacagctgga tccctccctg ggactgtctg taatgctaag   2820

acagggcagt gcatctgcaa gcccaatgtt gaagggagac agtgcaataa atgtttggag   2880

ggaaacttct acctacggca aaataattct ttcctctgtc tgccttgcaa ctgtgataag   2940

actgggacaa taaatggctc tctgctgtgt aacaaatcaa caggacaatg tccttgcaaa   3000

ttaggggtaa caggtcttcg ctgtaatcag tgtgagcctc acaggtacaa tttgaccatt   3060

gacaattttc aacactgcca gatgtgtgag tgtgattcct tggggacatt acctgggacc   3120

atttgtgacc caatcagtgg ccagtgcctg tgtgtgccta atcgtcaagg aagaaggtgt   3180

aatcagtgtc aaccaggttt ttatatttct ccaggcaatg ccactggctg cctgccatgc   3240

tcatgccata caactggtgc agttaatcac atctgtaata gcctgactgg tcagtgtgtt   3300

tgccaagatg cttccattgc tgggcaacgt tgtgaccaat gcaaagacca ttactttgga   3360

tttgatcctc agactggaag atgtcagcct tgtaattgtc atctctcagg agccttgaat   3420

gaaacctgtc acttggtcac aggccagtgt ttctgtaaac aatttgtcac tggctcaaag   3480

tgtgatgctt gtgttcccag tgcaagccac ttggatgtca acaatctatt gggttgcagc   3540

aaaactccat tccagcaacc tccgcccaga ggacaagttc aaagttcttc tgctatcaat   3600

ctctcctgga gtccacctga ttctccaaat gcccactggc ttacttacag tttactcagg   3660

gatggttttg aaatctacac aacagaggat caatacccat acagtattca atacttctta   3720

gacacagacc tgttaccata taccaaatat tcctattaca ttgagaccac caatgtgcat   3780

ggttcaacaa ggagtgtagc tgtcacttac aagacaaaac caggggtccc agagggaaac   3840

ttgactttaa gttatatcat tcctattggc tcagactctg tgacacttac ctggacaaca   3900

ctctcaaatc aatctggtcc catagagaaa tatattttgt cctgtgcccc tttggctggt   3960

ggtcagccat gtgtttccta cgaaggtcat gaaacctcag ctaccatctg gaatctggtt   4020

ccatttgcca agtacgattt ttctgtacag gcgtgtacta gcgggggctg tttacacagc   4080

ttgcccatta cagtgaccac agcccaggcc cctccccaaa gactaagtcc acctaagatg   4140

cagaaaatca gttctacaga acttcatgta gaatggtctc caccagcgga actaaatgga   4200

ataattataa gatatgaact atacatgaga agactgagat ctactaaaga aaccacatct   4260

gaggaaagtc gagtttttca gagcagtggt tggctcagtc ctcattcatt tgtagaatcg   4320

gccaatgaaa atgcattaaa acctcctcaa acaatgacaa ccatcactgg cttggagcca   4380

tacaccaagt atgagttcag agtcttagct gtgaatatgg ctggaagtgt gtcttctgcc   4440

tgggtctcag aaagaacggg agaatcagca cctgtattca tgatccctcc ttcagtcttt   4500

cccctctctt cgtactctct caatatctcc tgggagaagc cagcagataa tgttacaaga   4560

ggaaaagttg tggggtatga catcaatatg ctttctgaac aatcacctca acagtctatt   4620

cccatggcgt tttcacagct gttgcacact gctaaatccc aagaactatc ttacactgta   4680

gaaggactga aaccttatag gatatatgag tttactatta ctctctgcaa ttcagttggt   4740

tgtgtgacca gtgcttcggg agcaggacaa actttagcag cagcaccagc acaactgagg   4800

ccacctctgg ttaaaggaat caacagcaca acaatccatc ttaggtggtt tccacctgaa   4860

gaactgaatg gaccctctcc tatatatcag ctggaaagga gagagtcatc tctaccagct   4920

ctgatgacca cgatgatgaa aggaatccgt ttcataggaa atgggtattg taaatttccc   4980

agctccactc acccagtcaa tacagacttc actggtaagt gtgtttgaca ttgctttatt   5040

taggagacac gaagctccaa aatgttttct atattttcat atccctttac aatgaatttt   5100

tattatacct acttagagaa atactaattc agccctttga tagcttttgc ctgattgttt   5160

cagcatgtcc atctttttag aattctgggg aaaaaagtca ggtaagtgaa ggaaaggaaa   5220

aataaaagat gaagatgaag aagcagcctt attggatcaa agtatgtgct ttgtatttgt   5280

ctttttgtga agtatgtgcc aggacatgtt tcttgaaata ttattcactg tgttctctga   5340

gcaaatgagt ttgcaaaatg ccctcatgct attggagatt ctcagtatgc accccgttac   5400

tgaaactcca aaaagcattg taagaaagct attcaacttt gcttagctaa tcatgcctaa   5460

cagatatttg atgtaatgtt ttctttttct ttctcttgct gtttccttct tctttttttc   5520

actgtgacaa cttaatatct catgttctat gaagaacatt gtggggaaaa ctaatcccag   5580

ggaaaagata acttctctaa gccaggacta tggtaaagca agtgaggctc ttgtttcggt   5640

cacaaaattt aaaggcacta aaaaactcag tgttaatgta aattttaatg caatattttt   5700

aaaaatgaaa atcaatgtga aagcactata aaaatattat caaaagctta aataaagaca   5760

gattgaactc tgtaccagca caatcctgcc tcactggcct taccctcctc ctggccttac   5820

tagtaccgca atattttgga agtcccatga cctctgtgac ttacagcttc taatagcatg   5880

atttcaatat agctgtaaaa aaactctact tatggtacac catttttcca atttttaaaa   5940

aaatttacaa agtataagat atatattatt atgtaaactc ataaagatgt tcatttaatc   6000

atccatgaga aagtcatttt ggagcaaata gctagtcttt aaaatattgc atatgtgaag   6060

acaatgaaat ggaattcgag ctataaaaat ttgtattgtt ttatttttac ttaaaatagt   6120

aaatagtttg cttttcattg agactggctg ctgatgcacc ttggtaatga atcatgatta   6180

tattctaact gagatatatt gagattaatg catgattaac tactctctca gtacatcaaa   6240

atcattgcag agtattagaa attgaaccat tgagctaaaa atgctcaact tctgctttat   6300

attcttaaaa tggcaaaaaa aaaaaaaaaa aa                                 6332


<210>  410
<211>  1546
<212>  PRT
<213>  Homosapiens

<400>  410

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              


Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  


Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  


Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      


Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         


Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             


Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 


Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 


Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     


Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         


Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             


Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 


Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 


Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     


Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         


Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             


Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 


Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 


Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     


Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         


Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             


Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 


Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 


Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     


Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         


Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             


Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 


Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val 
465                 470                 475                 480 


Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     


Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         


Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             


Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 


Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 


Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     


Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         


Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             


Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 


Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 


Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             


Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 


Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 


Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     


Arg Ser Phe Asn Asp Val Gly Cys Glu Pro Cys Gln Cys Asn Leu His 
            740                 745                 750         


Gly Ser Val Asn Lys Phe Cys Asn Pro His Ser Gly Gln Cys Glu Cys 
        755                 760                 765             


Lys Lys Glu Ala Lys Gly Leu Gln Cys Asp Thr Cys Arg Glu Asn Phe 
    770                 775                 780                 


Tyr Gly Leu Asp Val Thr Asn Cys Lys Ala Cys Asp Cys Asp Thr Ala 
785                 790                 795                 800 


Gly Ser Leu Pro Gly Thr Val Cys Asn Ala Lys Thr Gly Gln Cys Ile 
                805                 810                 815     


Cys Lys Pro Asn Val Glu Gly Arg Gln Cys Asn Lys Cys Leu Glu Gly 
            820                 825                 830         


Asn Phe Tyr Leu Arg Gln Asn Asn Ser Phe Leu Cys Leu Pro Cys Asn 
        835                 840                 845             


Cys Asp Lys Thr Gly Thr Ile Asn Gly Ser Leu Leu Cys Asn Lys Ser 
    850                 855                 860                 


Thr Gly Gln Cys Pro Cys Lys Leu Gly Val Thr Gly Leu Arg Cys Asn 
865                 870                 875                 880 


Gln Cys Glu Pro His Arg Tyr Asn Leu Thr Ile Asp Asn Phe Gln His 
                885                 890                 895     


Cys Gln Met Cys Glu Cys Asp Ser Leu Gly Thr Leu Pro Gly Thr Ile 
            900                 905                 910         


Cys Asp Pro Ile Ser Gly Gln Cys Leu Cys Val Pro Asn Arg Gln Gly 
        915                 920                 925             


Arg Arg Cys Asn Gln Cys Gln Pro Gly Phe Tyr Ile Ser Pro Gly Asn 
    930                 935                 940                 


Ala Thr Gly Cys Leu Pro Cys Ser Cys His Thr Thr Gly Ala Val Asn 
945                 950                 955                 960 


His Ile Cys Asn Ser Leu Thr Gly Gln Cys Val Cys Gln Asp Ala Ser 
                965                 970                 975     


Ile Ala Gly Gln Arg Cys Asp Gln Cys Lys Asp His Tyr Phe Gly Phe 
            980                 985                 990         


Asp Pro Gln Thr Gly Arg Cys Gln  Pro Cys Asn Cys His  Leu Ser Gly 
        995                 1000                 1005             


Ala Leu  Asn Glu Thr Cys His  Leu Val Thr Gly Gln  Cys Phe Cys 
    1010                 1015                 1020             


Lys Gln  Phe Val Thr Gly Ser  Lys Cys Asp Ala Cys  Val Pro Ser 
    1025                 1030                 1035             


Ala Ser  His Leu Asp Val Asn  Asn Leu Leu Gly Cys  Ser Lys Thr 
    1040                 1045                 1050             


Pro Phe  Gln Gln Pro Pro Pro  Arg Gly Gln Val Gln  Ser Ser Ser 
    1055                 1060                 1065             


Ala Ile  Asn Leu Ser Trp Ser  Pro Pro Asp Ser Pro  Asn Ala His 
    1070                 1075                 1080             


Trp Leu  Thr Tyr Ser Leu Leu  Arg Asp Gly Phe Glu  Ile Tyr Thr 
    1085                 1090                 1095             


Thr Glu  Asp Gln Tyr Pro Tyr  Ser Ile Gln Tyr Phe  Leu Asp Thr 
    1100                 1105                 1110             


Asp Leu  Leu Pro Tyr Thr Lys  Tyr Ser Tyr Tyr Ile  Glu Thr Thr 
    1115                 1120                 1125             


Asn Val  His Gly Ser Thr Arg  Ser Val Ala Val Thr  Tyr Lys Thr 
    1130                 1135                 1140             


Lys Pro  Gly Val Pro Glu Gly  Asn Leu Thr Leu Ser  Tyr Ile Ile 
    1145                 1150                 1155             


Pro Ile  Gly Ser Asp Ser Val  Thr Leu Thr Trp Thr  Thr Leu Ser 
    1160                 1165                 1170             


Asn Gln  Ser Gly Pro Ile Glu  Lys Tyr Ile Leu Ser  Cys Ala Pro 
    1175                 1180                 1185             


Leu Ala  Gly Gly Gln Pro Cys  Val Ser Tyr Glu Gly  His Glu Thr 
    1190                 1195                 1200             


Ser Ala  Thr Ile Trp Asn Leu  Val Pro Phe Ala Lys  Tyr Asp Phe 
    1205                 1210                 1215             


Ser Val  Gln Ala Cys Thr Ser  Gly Gly Cys Leu His  Ser Leu Pro 
    1220                 1225                 1230             


Ile Thr  Val Thr Thr Ala Gln  Ala Pro Pro Gln Arg  Leu Ser Pro 
    1235                 1240                 1245             


Pro Lys  Met Gln Lys Ile Ser  Ser Thr Glu Leu His  Val Glu Trp 
    1250                 1255                 1260             


Ser Pro  Pro Ala Glu Leu Asn  Gly Ile Ile Ile Arg  Tyr Glu Leu 
    1265                 1270                 1275             


Tyr Met  Arg Arg Leu Arg Ser  Thr Lys Glu Thr Thr  Ser Glu Glu 
    1280                 1285                 1290             


Ser Arg  Val Phe Gln Ser Ser  Gly Trp Leu Ser Pro  His Ser Phe 
    1295                 1300                 1305             


Val Glu  Ser Ala Asn Glu Asn  Ala Leu Lys Pro Pro  Gln Thr Met 
    1310                 1315                 1320             


Thr Thr  Ile Thr Gly Leu Glu  Pro Tyr Thr Lys Tyr  Glu Phe Arg 
    1325                 1330                 1335             


Val Leu  Ala Val Asn Met Ala  Gly Ser Val Ser Ser  Ala Trp Val 
    1340                 1345                 1350             


Ser Glu  Arg Thr Gly Glu Ser  Ala Pro Val Phe Met  Ile Pro Pro 
    1355                 1360                 1365             


Ser Val  Phe Pro Leu Ser Ser  Tyr Ser Leu Asn Ile  Ser Trp Glu 
    1370                 1375                 1380             


Lys Pro  Ala Asp Asn Val Thr  Arg Gly Lys Val Val  Gly Tyr Asp 
    1385                 1390                 1395             


Ile Asn  Met Leu Ser Glu Gln  Ser Pro Gln Gln Ser  Ile Pro Met 
    1400                 1405                 1410             


Ala Phe  Ser Gln Leu Leu His  Thr Ala Lys Ser Gln  Glu Leu Ser 
    1415                 1420                 1425             


Tyr Thr  Val Glu Gly Leu Lys  Pro Tyr Arg Ile Tyr  Glu Phe Thr 
    1430                 1435                 1440             


Ile Thr  Leu Cys Asn Ser Val  Gly Cys Val Thr Ser  Ala Ser Gly 
    1445                 1450                 1455             


Ala Gly  Gln Thr Leu Ala Ala  Ala Pro Ala Gln Leu  Arg Pro Pro 
    1460                 1465                 1470             


Leu Val  Lys Gly Ile Asn Ser  Thr Thr Ile His Leu  Arg Trp Phe 
    1475                 1480                 1485             


Pro Pro  Glu Glu Leu Asn Gly  Pro Ser Pro Ile Tyr  Gln Leu Glu 
    1490                 1495                 1500             


Arg Arg  Glu Ser Ser Leu Pro  Ala Leu Met Thr Thr  Met Met Lys 
    1505                 1510                 1515             


Gly Ile  Arg Phe Ile Gly Asn  Gly Tyr Cys Lys Phe  Pro Ser Ser 
    1520                 1525                 1530             


Thr His  Pro Val Asn Thr Asp  Phe Thr Gly Lys Cys  Val 
    1535                 1540                 1545     


<210>  411
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  411
tgtttgctct gcagaatact ttacctgggc acccaagtct tccttccagc attcctgctg     60

ctacagccta tttgctgagt aaccaggggt tacagcagcg ttgccaggca acgagggaca    120

gcggtcctgt tgaagagcca tttgtcacac tgaggggact ggttgaaatg caataaagaa    180

atgataccag cagctactca tgtcttcgcc attgctaaga acgtcgttgg tattacctta    240

ctctgagaac gtgtctgcag tttccagaaa atggagtatc gcaacatcac ttaaagtacc    300

ctgcttcaaa gtattgctgg caagtggcgt gggcctgatt atttatttag aaatgcttta    360

tcaggaggag aatgcttttt tgtaaacatg aattgcccag ttctttcatt gggctctggc    420

ttcttgtttc aggtcattga aatgttgatc tttgcctatt ttgcttcaat atccttgact    480

gagtcacgag gtcttttccc aaggctggag aacgtgggag ctttcaagaa agtttccatc    540

gtgccaaccc aagcagtatg tggactccca gaccgaagca ctttttgtca cagctctgct    600

gctgctgaaa gtattcagtt ctgtacccag cggttttgta ttcaggattg cccatacaga    660

tcttcacacc ctacctacac tgcccttttc tcagcaggcc tcagtagctg catcacacca    720

gacaagaatg atctgcatcc taacgcccat agcaattctg caagttttat ttttggaaat    780

cacaagagct gcttttcttc tcctccttct ccaaagctga tggcatcatt taccttagct    840

gtatggctga aacctgagca acaaggtgta atgtgtgtta tagaaaagac agtagatggg    900

cagattgtgt tcaaacttac aatatctgag aaagagacca tgttttatta tcgcacagta    960

aatggtttgc aacctccaat aaaagtaatg acactgggga gaattcttgt gaagaaatgg   1020

attcatctta gtgtgcaggt gcatcagaca aaaatcagct tctttatcaa tggcgtggag   1080

aaggatcata cacctttcaa tgcaagaact ctaagtggtt caattacaga ttttgcatct   1140

ggtactgtgc aaataggaca gagtttaaat ggtttagagc agtttgtcgg aagaatgcaa   1200

gattttcgat tataccaagt ggcacttaca aacagagaga ttctggaagt cttctctgga   1260

gatcttctca gattgcatgc ccaatcacat tgccgttgcc ctggcagcca cccgcgggtc   1320

caccctttgg cacagcggta ctgcattcct aatgatgcag gagacacagc tgataataga   1380

gtgtcacggt tgaatcctga agcccatcct ctctcttttg tcaatgataa tgatgttggt   1440

acttcatggg tttcaaatgt gtttacaaac attacacagc ttaatcaagg agtgactatt   1500

tcagttgatt tggaaaatgg acagtatcag gtgttttata ttatcattca gttctttagt   1560

ccacaaccaa cggaaataag gattcaaagg aagaaggaaa atagtttaga ttgggaggac   1620

tggcaatatt ttgccaggaa ttgtggtgct tttggaatga aaaacaatgg agatttggaa   1680

aaacctgatt ctgtcaactg tcttcagctt tccaatttta ctccatattc ccgtggcaat   1740

gtcacattta gcatcctgac acctggacca aattatcgtc ctggatacaa taacttctat   1800

aataccccat ctcttcaaga gttcgtaaaa gccacgcaaa taaggtttca ttttcatggg   1860

cagtactata caactgagac tgctgttaac ctcagacaca gatattatgc agtggacgaa   1920

atcaccatta gtgggagatg tcagtgccat ggtcatgccg ataactgcga cacaacaagc   1980

cagccatata gatgcctctg ctcccaggag agcttcactg aaggacttca ttgtgatcgc   2040

tgcttgcctc tttataatga caagcctttc cgccaaggtg atcaagttta cgctttcaat   2100

tgtaaacctt gtcaatgcaa cagccattcc aaaagctgcc attacaacat ctctgtagac   2160

ccatttcctt ttgagcactt cagaggggga ggaggagttt gtgatgattg tgagcataac   2220

actacaggaa ggaactgtga gctgtgcaag gattactttt tccgacaagt tggtgcagat   2280

ccttcggcca tagatgtttg caaaccctgt gactgtgata cagttggcac tagaaatggt   2340

agcattcttt gtgatcagat tggaggacag tgtaattgta agagacacgt gtctggcagg   2400

cagtgcaatc agtgccagaa tggattctac aatctacaag agttggatcc tgatggctgc   2460

agtccctgta actgcaatac ctctgggaca gtggatggag atattacctg tcaccaaaat   2520

tcaggccagt gcaagtgcaa agcaaacgtt attgggctta ggtgtgatca ttgcaatttt   2580

ggatttaaat ttctccgaag ctttaatgat gttggatgtg agccctgcca gtgtaacctc   2640

catggctcag tgaacaaatt ctgcaatcct cactctgggc agtgtgagtg caaaaaagaa   2700

gccaaaggac ttcagtgtga cacctgcaga gaaaactttt atgggttaga tgtcaccaat   2760

tgtaaggcct gtgactgtga cacagctgga tccctccctg ggactgtctg taatgctaag   2820

acagggcagt gcatctgcaa gcccaatgtt gaagggagac agtgcaataa atgtttggag   2880

ggaaacttct acctacggca aaataattct ttcctctgtc tgccttgcaa ctgtgataag   2940

actgggacaa taaatggctc tctgctgtgt aacaaatcaa caggacaatg tccttgcaaa   3000

ttaggggtaa caggtcttcg ctgtaatcag tgtgagcctc acaggtacaa tttgaccatt   3060

gacaattttc aacactgcca gatgtgtgag tgtgattcct tggggacatt acctgggacc   3120

atttgtgacc caatcagtgg ccagtgcctg tgtgtgccta atcgtcaagg aagaaggtgt   3180

aatcagtgtc aaccaggttt ttatatttct ccaggcaatg ccactggctg cctgccatgc   3240

tcatgccata caactggtgc agttaatcac atctgtaata gcctgactgg tcagtgtgtt   3300

tgccaagatg cttccattgc tgggcaacgt tgtgaccaat gcaaagacca ttactttgga   3360

tttgatcctc agactggaag atgtcagcct tgtaattgtc atctctcagg agccttgaat   3420

gaaacctgtc acttggtcac aggccagtgt ttctgtaaac aatttgtcac tggctcaaag   3480

tgtgatgctt gtgttcccag tgcaagccac ttggatgtca acaatctatt gggttgcagc   3540

aaaactccat tccagcaacc tccgcccaga ggacaagttc aaagttcttc tgctatcaat   3600

ctctcctgga gtccacctga ttctccaaat gcccactggc ttacttacag tttactcagg   3660

gatggttttg aaatctacac aacagaggat caatacccat acagtattca atacttctta   3720

gacacagacc tgttaccata taccaaatat tcctattaca ttgagaccac caatgtgcat   3780

ggttcaacaa ggagtgtagc tgtcacttac aagacaaaac caggggtccc agagggaaac   3840

ttgactttaa gttatatcat tcctattggc tcagactctg tgacacttac ctggacaaca   3900

ctctcaaatc aatctggtcc catagagaaa tatattttgt cctgtgcccc tttggctggt   3960

ggtcagccat gtgtttccta cgaaggtcat gaaacctcag ctaccatctg gaatctggtt   4020

ccatttgcca agtacgattt ttctgtacag gcgtgtacta gcgggggctg tttacacagc   4080

ttgcccatta cagtgaccac agcccaggcc cctccccaaa gactaagtcc acctaagatg   4140

cagaaaatca gttctacaga acttcatgta gaatggtctc caccagcgga actaaatgga   4200

ataattataa gatatgaact atacatgaga agactgagat ctactaaaga aaccacatct   4260

gaggaaagtc gagtttttca gagcagtggt tggctcagtc ctcattcatt tgtagaatcg   4320

gccaatgaaa atgcattaaa acctcctcaa acaatgacaa ccatcactgg cttggagcca   4380

tacaccaagt atgagttcag agtcttagct gtgaatatgg ctggaagtgt gtcttctgcc   4440

tgggtctcag aaagaacggg agaatcagca cctgtattca tgatccctcc ttcagtcttt   4500

cccctctctt cgtactctct caatatctcc tgggagaagc cagcagataa tgttacaaga   4560

ggaaaagttg tggggtatga catcaatatg ctttctgaac aatcacctca acagtctatt   4620

cccatggcgt tttcacagct gttgcacact gctaaatccc aagaactatc ttacactgta   4680

gaaggactga aaccttatag gatatatgag tttactatta ctctctgcaa ttcagttggt   4740

tgtgtgacca gtgcttcggg agcaggacaa actttagcag cagcaccagc acaactgagg   4800

ccacctctgg ttaaaggaat caacagcaca acaatccatc ttaggtggtt tccacctgaa   4860

gaactgaatg gaccctctcc tatatatcag ctggaaagga gagagtcatc tctaccagct   4920

ctgatgacca cgatgatgaa aggaatccgt ttcataggaa atgggtattg taaatttccc   4980

agctccactc acccagtcaa tacagacttc actggcatta aggccagctt tcgaacaaaa   5040

gtgcctgaag gtttgattgt ctttgcagca tcacctggca atcaggaaga gtattttgca   5100

cttcagttga agaagggacg tctttatttt ctttttgatc ctcaggggtc accagtggaa   5160

gtaactacaa ctaatgatca tggcaaacaa tatagtgatg gaaaatggca tgaaataatt   5220

gctattaggc atcaggcttt tggccaaatc actctggatg ggatatatac aggttcctct   5280

gccatcctga atggtagtac tgttattgga gataacacag gagtctttct gggagggctc   5340

ccgcgaagtt ataccatcct caggaaggat cctgagataa tccaaaaagg ttttgtgggc   5400

tgtctcaagg atgtacattt tatgaagaat tacaatccgt cagctatttg ggaacctctg   5460

gattggcaga gttctgaaga acaaatcaac gtgtataaca gctgggaggg atgtcccgct   5520

tcattaaatg agggagctca gttcctagga gcagggttcc tggaacttca tccatatatg   5580

tttcatggtg gaatgaactt tgagatttcc tttaagttca gaactgacca attaaatgga   5640

ttgcttcttt tcgtttataa caaagatgga cctgattttc ttgctatgga gctgaaaagt   5700

ggaatattga ccttccggtt aaataccagt cttgccttta cacaagtgga tctattgctg   5760

gggctatcct attgtaatgg aaagtggaat aaagtcatta ttaaaaagga aggctctttc   5820

atatcagcaa gtgtgaatgg actgatgaag catgcatcgg agtccggaga ccagccactg   5880

gtggtgaatt caccagttta tgtgggagga atcccacagg aactgctgaa ctcttatcaa   5940

catttgtgtt tggaacaagg tttcggtggt tgcatgaagg atgttaaatt tacacggggt   6000

gctgtcgtta acttggcatc tgtgtccagc ggtgctgtca gagtcaatct ggatggatgc   6060

ctatcaactg acagtgctgt taactgcagg ggaaatgact ccatcctggt ttaccaggga   6120

aaagagcaga gtgtttacga gggtggtctc cagcctttta cagaatacct gtatcgagtg   6180

atagcctcgc atgaaggagg ttcagtatat agtgattgga gtcgaggacg tacaacagga   6240

gcagctccac aaagtgtgcc aactccctca agagtccgca gcttaaatgg atacagcatt   6300

gaggtgacct gggatgaacc tgttgtcaga ggtgtaattg agaagtacat tctgaaagcc   6360

tatagtgagg acagcacccg tccaccccgc atgccctctg ccagtgctga atttgtcaat   6420

acaagcaacc tcacaggcat attgacaggc ttgctaccct tcaaaaacta tgcagtaacc   6480

ctaactgctt gcactttggc tggctgtact gagagctcac atgcattgaa catctctact   6540

ccacaagaag ccccacaaga ggttcagcca ccagtagcca aatcccttcc cagttctttg   6600

ctgctctcct ggaacccacc caaaaaggca aatggtatta taactcagta ctgtttatac   6660

atggatggga ggctgatcta ttcaggcagt gaggagaact acatagtcac agatttagca   6720

gtatttacac cccaccagtt tctactaagt gcatgcacac atgtgggctg tacaaacagt   6780

tcctgggtcc tactgtacac agcacagctg ccaccagaac acgtggattc cccagttctg   6840

actgtcctgg attctagaac tatacacata cagtggaaac aaccaagaaa aataagtggg   6900

attctggaac gctatgtatt atatatgtca aaccatacac atgattttac aatttggagt   6960

gtcatctata acagtacaga acttttccag gatcatatgc tacaatacgt tttacctggt   7020

aataaatatc tcatcaagct gggagcttgc acaggtggtg ggtgcacagt gagtgaggcc   7080

agtgaggccc taactgacga ggacataccc gaaggcgtgc cagcccccaa agcccactca   7140

tattcacctg actcctttaa tgtctcctgg actgagcctg aatatccgaa tggtgttatc   7200

acgagttatg gattatatct agatggtata ttaatccaca attcctcaga actcagctat   7260

cgtgcttacg gatttgctcc ttggagttta cattccttca gagtccaagc atgcacggcc   7320

aaaggttgtg ctctgggccc actggtggaa aatcgaactc tagaagctcc tcctgaagga   7380

acagtaaatg tgtttgtcaa aacacaggga tcccggaaag cccacgtgag gtgggaagca   7440

ccttttcgcc ctaatggact cttaacacac tcagtccttt tcactgggat attctatgta   7500

gacccagtag gtaataacta cacccttctg aatgtcacaa aagtcatgta cagcggagaa   7560

gagacaaacc tttgggtgct catcgatggg ctggttcctt ttaccaacta tactgtacaa   7620

gtgaatattt caaatagcca aggcagcttg ataactgatc ctataacaat tgcaatgcct   7680

ccaggagctc cagatggcgt gctgcctccc aggctttcat ctgccactcc aaccagtctt   7740

caggttgtct ggtctacacc agctcgtaat aacgctcctg gctctcccag ataccaactc   7800

cagatgaggt ctggcgactc cacccatgga tttctagagt tattttccaa tccttctgca   7860

tcgttaagct atgaagtgag tgatctccaa ccgtacacag agtatatgtt tcggttggtt   7920

gcctccaatg gatttggcag tgcacatagt tcttggattc cattcatgac cgcagaggac   7980

aaacctggac ctgtagttcc tccgattctt ctggatgtga agtcaagaat gatgttggtc   8040

acctggcagc atcctagaaa atccaatggg gttattaccc attataacat ttatctacat   8100

ggccgtctat acttgagaac tcctggaaat gtcactaatt gcacagtgat gcatttacac   8160

ccatacactg cctataagtt tcaggtagaa gc                                 8192


<210>  412
<211>  5202
<212>  PRT
<213>  Homosapiens

<400>  412

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              


Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  


Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  


Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      


Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         


Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             


Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 


Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 


Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     


Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         


Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             


Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 


Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 


Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     


Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         


Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             


Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 


Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 


Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     


Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         


Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             


Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 


Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 


Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     


Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         


Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             


Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 


Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val 
465                 470                 475                 480 


Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     


Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         


Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             


Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 


Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 


Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     


Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         


Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             


Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 


Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 


Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             


Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 


Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 


Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     


Arg Ser Phe Asn Asp Val Gly Cys Glu Pro Cys Gln Cys Asn Leu His 
            740                 745                 750         


Gly Ser Val Asn Lys Phe Cys Asn Pro His Ser Gly Gln Cys Glu Cys 
        755                 760                 765             


Lys Lys Glu Ala Lys Gly Leu Gln Cys Asp Thr Cys Arg Glu Asn Phe 
    770                 775                 780                 


Tyr Gly Leu Asp Val Thr Asn Cys Lys Ala Cys Asp Cys Asp Thr Ala 
785                 790                 795                 800 


Gly Ser Leu Pro Gly Thr Val Cys Asn Ala Lys Thr Gly Gln Cys Ile 
                805                 810                 815     


Cys Lys Pro Asn Val Glu Gly Arg Gln Cys Asn Lys Cys Leu Glu Gly 
            820                 825                 830         


Asn Phe Tyr Leu Arg Gln Asn Asn Ser Phe Leu Cys Leu Pro Cys Asn 
        835                 840                 845             


Cys Asp Lys Thr Gly Thr Ile Asn Gly Ser Leu Leu Cys Asn Lys Ser 
    850                 855                 860                 


Thr Gly Gln Cys Pro Cys Lys Leu Gly Val Thr Gly Leu Arg Cys Asn 
865                 870                 875                 880 


Gln Cys Glu Pro His Arg Tyr Asn Leu Thr Ile Asp Asn Phe Gln His 
                885                 890                 895     


Cys Gln Met Cys Glu Cys Asp Ser Leu Gly Thr Leu Pro Gly Thr Ile 
            900                 905                 910         


Cys Asp Pro Ile Ser Gly Gln Cys Leu Cys Val Pro Asn Arg Gln Gly 
        915                 920                 925             


Arg Arg Cys Asn Gln Cys Gln Pro Gly Phe Tyr Ile Ser Pro Gly Asn 
    930                 935                 940                 


Ala Thr Gly Cys Leu Pro Cys Ser Cys His Thr Thr Gly Ala Val Asn 
945                 950                 955                 960 


His Ile Cys Asn Ser Leu Thr Gly Gln Cys Val Cys Gln Asp Ala Ser 
                965                 970                 975     


Ile Ala Gly Gln Arg Cys Asp Gln Cys Lys Asp His Tyr Phe Gly Phe 
            980                 985                 990         


Asp Pro Gln Thr Gly Arg Cys Gln  Pro Cys Asn Cys His  Leu Ser Gly 
        995                 1000                 1005             


Ala Leu  Asn Glu Thr Cys His  Leu Val Thr Gly Gln  Cys Phe Cys 
    1010                 1015                 1020             


Lys Gln  Phe Val Thr Gly Ser  Lys Cys Asp Ala Cys  Val Pro Ser 
    1025                 1030                 1035             


Ala Ser  His Leu Asp Val Asn  Asn Leu Leu Gly Cys  Ser Lys Thr 
    1040                 1045                 1050             


Pro Phe  Gln Gln Pro Pro Pro  Arg Gly Gln Val Gln  Ser Ser Ser 
    1055                 1060                 1065             


Ala Ile  Asn Leu Ser Trp Ser  Pro Pro Asp Ser Pro  Asn Ala His 
    1070                 1075                 1080             


Trp Leu  Thr Tyr Ser Leu Leu  Arg Asp Gly Phe Glu  Ile Tyr Thr 
    1085                 1090                 1095             


Thr Glu  Asp Gln Tyr Pro Tyr  Ser Ile Gln Tyr Phe  Leu Asp Thr 
    1100                 1105                 1110             


Asp Leu  Leu Pro Tyr Thr Lys  Tyr Ser Tyr Tyr Ile  Glu Thr Thr 
    1115                 1120                 1125             


Asn Val  His Gly Ser Thr Arg  Ser Val Ala Val Thr  Tyr Lys Thr 
    1130                 1135                 1140             


Lys Pro  Gly Val Pro Glu Gly  Asn Leu Thr Leu Ser  Tyr Ile Ile 
    1145                 1150                 1155             


Pro Ile  Gly Ser Asp Ser Val  Thr Leu Thr Trp Thr  Thr Leu Ser 
    1160                 1165                 1170             


Asn Gln  Ser Gly Pro Ile Glu  Lys Tyr Ile Leu Ser  Cys Ala Pro 
    1175                 1180                 1185             


Leu Ala  Gly Gly Gln Pro Cys  Val Ser Tyr Glu Gly  His Glu Thr 
    1190                 1195                 1200             


Ser Ala  Thr Ile Trp Asn Leu  Val Pro Phe Ala Lys  Tyr Asp Phe 
    1205                 1210                 1215             


Ser Val  Gln Ala Cys Thr Ser  Gly Gly Cys Leu His  Ser Leu Pro 
    1220                 1225                 1230             


Ile Thr  Val Thr Thr Ala Gln  Ala Pro Pro Gln Arg  Leu Ser Pro 
    1235                 1240                 1245             


Pro Lys  Met Gln Lys Ile Ser  Ser Thr Glu Leu His  Val Glu Trp 
    1250                 1255                 1260             


Ser Pro  Pro Ala Glu Leu Asn  Gly Ile Ile Ile Arg  Tyr Glu Leu 
    1265                 1270                 1275             


Tyr Met  Arg Arg Leu Arg Ser  Thr Lys Glu Thr Thr  Ser Glu Glu 
    1280                 1285                 1290             


Ser Arg  Val Phe Gln Ser Ser  Gly Trp Leu Ser Pro  His Ser Phe 
    1295                 1300                 1305             


Val Glu  Ser Ala Asn Glu Asn  Ala Leu Lys Pro Pro  Gln Thr Met 
    1310                 1315                 1320             


Thr Thr  Ile Thr Gly Leu Glu  Pro Tyr Thr Lys Tyr  Glu Phe Arg 
    1325                 1330                 1335             


Val Leu  Ala Val Asn Met Ala  Gly Ser Val Ser Ser  Ala Trp Val 
    1340                 1345                 1350             


Ser Glu  Arg Thr Gly Glu Ser  Ala Pro Val Phe Met  Ile Pro Pro 
    1355                 1360                 1365             


Ser Val  Phe Pro Leu Ser Ser  Tyr Ser Leu Asn Ile  Ser Trp Glu 
    1370                 1375                 1380             


Lys Pro  Ala Asp Asn Val Thr  Arg Gly Lys Val Val  Gly Tyr Asp 
    1385                 1390                 1395             


Ile Asn  Met Leu Ser Glu Gln  Ser Pro Gln Gln Ser  Ile Pro Met 
    1400                 1405                 1410             


Ala Phe  Ser Gln Leu Leu His  Thr Ala Lys Ser Gln  Glu Leu Ser 
    1415                 1420                 1425             


Tyr Thr  Val Glu Gly Leu Lys  Pro Tyr Arg Ile Tyr  Glu Phe Thr 
    1430                 1435                 1440             


Ile Thr  Leu Cys Asn Ser Val  Gly Cys Val Thr Ser  Ala Ser Gly 
    1445                 1450                 1455             


Ala Gly  Gln Thr Leu Ala Ala  Ala Pro Ala Gln Leu  Arg Pro Pro 
    1460                 1465                 1470             


Leu Val  Lys Gly Ile Asn Ser  Thr Thr Ile His Leu  Arg Trp Phe 
    1475                 1480                 1485             


Pro Pro  Glu Glu Leu Asn Gly  Pro Ser Pro Ile Tyr  Gln Leu Glu 
    1490                 1495                 1500             


Arg Arg  Glu Ser Ser Leu Pro  Ala Leu Met Thr Thr  Met Met Lys 
    1505                 1510                 1515             


Gly Ile  Arg Phe Ile Gly Asn  Gly Tyr Cys Lys Phe  Pro Ser Ser 
    1520                 1525                 1530             


Thr His  Pro Val Asn Thr Asp  Phe Thr Gly Ile Lys  Ala Ser Phe 
    1535                 1540                 1545             


Arg Thr  Lys Val Pro Glu Gly  Leu Ile Val Phe Ala  Ala Ser Pro 
    1550                 1555                 1560             


Gly Asn  Gln Glu Glu Tyr Phe  Ala Leu Gln Leu Lys  Lys Gly Arg 
    1565                 1570                 1575             


Leu Tyr  Phe Leu Phe Asp Pro  Gln Gly Ser Pro Val  Glu Val Thr 
    1580                 1585                 1590             


Thr Thr  Asn Asp His Gly Lys  Gln Tyr Ser Asp Gly  Lys Trp His 
    1595                 1600                 1605             


Glu Ile  Ile Ala Ile Arg His  Gln Ala Phe Gly Gln  Ile Thr Leu 
    1610                 1615                 1620             


Asp Gly  Ile Tyr Thr Gly Ser  Ser Ala Ile Leu Asn  Gly Ser Thr 
    1625                 1630                 1635             


Val Ile  Gly Asp Asn Thr Gly  Val Phe Leu Gly Gly  Leu Pro Arg 
    1640                 1645                 1650             


Ser Tyr  Thr Ile Leu Arg Lys  Asp Pro Glu Ile Ile  Gln Lys Gly 
    1655                 1660                 1665             


Phe Val  Gly Cys Leu Lys Asp  Val His Phe Met Lys  Asn Tyr Asn 
    1670                 1675                 1680             


Pro Ser  Ala Ile Trp Glu Pro  Leu Asp Trp Gln Ser  Ser Glu Glu 
    1685                 1690                 1695             


Gln Ile  Asn Val Tyr Asn Ser  Trp Glu Gly Cys Pro  Ala Ser Leu 
    1700                 1705                 1710             


Asn Glu  Gly Ala Gln Phe Leu  Gly Ala Gly Phe Leu  Glu Leu His 
    1715                 1720                 1725             


Pro Tyr  Met Phe His Gly Gly  Met Asn Phe Glu Ile  Ser Phe Lys 
    1730                 1735                 1740             


Phe Arg  Thr Asp Gln Leu Asn  Gly Leu Leu Leu Phe  Val Tyr Asn 
    1745                 1750                 1755             


Lys Asp  Gly Pro Asp Phe Leu  Ala Met Glu Leu Lys  Ser Gly Ile 
    1760                 1765                 1770             


Leu Thr  Phe Arg Leu Asn Thr  Ser Leu Ala Phe Thr  Gln Val Asp 
    1775                 1780                 1785             


Leu Leu  Leu Gly Leu Ser Tyr  Cys Asn Gly Lys Trp  Asn Lys Val 
    1790                 1795                 1800             


Ile Ile  Lys Lys Glu Gly Ser  Phe Ile Ser Ala Ser  Val Asn Gly 
    1805                 1810                 1815             


Leu Met  Lys His Ala Ser Glu  Ser Gly Asp Gln Pro  Leu Val Val 
    1820                 1825                 1830             


Asn Ser  Pro Val Tyr Val Gly  Gly Ile Pro Gln Glu  Leu Leu Asn 
    1835                 1840                 1845             


Ser Tyr  Gln His Leu Cys Leu  Glu Gln Gly Phe Gly  Gly Cys Met 
    1850                 1855                 1860             


Lys Asp  Val Lys Phe Thr Arg  Gly Ala Val Val Asn  Leu Ala Ser 
    1865                 1870                 1875             


Val Ser  Ser Gly Ala Val Arg  Val Asn Leu Asp Gly  Cys Leu Ser 
    1880                 1885                 1890             


Thr Asp  Ser Ala Val Asn Cys  Arg Gly Asn Asp Ser  Ile Leu Val 
    1895                 1900                 1905             


Tyr Gln  Gly Lys Glu Gln Ser  Val Tyr Glu Gly Gly  Leu Gln Pro 
    1910                 1915                 1920             


Phe Thr  Glu Tyr Leu Tyr Arg  Val Ile Ala Ser His  Glu Gly Gly 
    1925                 1930                 1935             


Ser Val  Tyr Ser Asp Trp Ser  Arg Gly Arg Thr Thr  Gly Ala Ala 
    1940                 1945                 1950             


Pro Gln  Ser Val Pro Thr Pro  Ser Arg Val Arg Ser  Leu Asn Gly 
    1955                 1960                 1965             


Tyr Ser  Ile Glu Val Thr Trp  Asp Glu Pro Val Val  Arg Gly Val 
    1970                 1975                 1980             


Ile Glu  Lys Tyr Ile Leu Lys  Ala Tyr Ser Glu Asp  Ser Thr Arg 
    1985                 1990                 1995             


Pro Pro  Arg Met Pro Ser Ala  Ser Ala Glu Phe Val  Asn Thr Ser 
    2000                 2005                 2010             


Asn Leu  Thr Gly Ile Leu Thr  Gly Leu Leu Pro Phe  Lys Asn Tyr 
    2015                 2020                 2025             


Ala Val  Thr Leu Thr Ala Cys  Thr Leu Ala Gly Cys  Thr Glu Ser 
    2030                 2035                 2040             


Ser His  Ala Leu Asn Ile Ser  Thr Pro Gln Glu Ala  Pro Gln Glu 
    2045                 2050                 2055             


Val Gln  Pro Pro Val Ala Lys  Ser Leu Pro Ser Ser  Leu Leu Leu 
    2060                 2065                 2070             


Ser Trp  Asn Pro Pro Lys Lys  Ala Asn Gly Ile Ile  Thr Gln Tyr 
    2075                 2080                 2085             


Cys Leu  Tyr Met Asp Gly Arg  Leu Ile Tyr Ser Gly  Ser Glu Glu 
    2090                 2095                 2100             


Asn Tyr  Ile Val Thr Asp Leu  Ala Val Phe Thr Pro  His Gln Phe 
    2105                 2110                 2115             


Leu Leu  Ser Ala Cys Thr His  Val Gly Cys Thr Asn  Ser Ser Trp 
    2120                 2125                 2130             


Val Leu  Leu Tyr Thr Ala Gln  Leu Pro Pro Glu His  Val Asp Ser 
    2135                 2140                 2145             


Pro Val  Leu Thr Val Leu Asp  Ser Arg Thr Ile His  Ile Gln Trp 
    2150                 2155                 2160             


Lys Gln  Pro Arg Lys Ile Ser  Gly Ile Leu Glu Arg  Tyr Val Leu 
    2165                 2170                 2175             


Tyr Met  Ser Asn His Thr His  Asp Phe Thr Ile Trp  Ser Val Ile 
    2180                 2185                 2190             


Tyr Asn  Ser Thr Glu Leu Phe  Gln Asp His Met Leu  Gln Tyr Val 
    2195                 2200                 2205             


Leu Pro  Gly Asn Lys Tyr Leu  Ile Lys Leu Gly Ala  Cys Thr Gly 
    2210                 2215                 2220             


Gly Gly  Cys Thr Val Ser Glu  Ala Ser Glu Ala Leu  Thr Asp Glu 
    2225                 2230                 2235             


Asp Ile  Pro Glu Gly Val Pro  Ala Pro Lys Ala His  Ser Tyr Ser 
    2240                 2245                 2250             


Pro Asp  Ser Phe Asn Val Ser  Trp Thr Glu Pro Glu  Tyr Pro Asn 
    2255                 2260                 2265             


Gly Val  Ile Thr Ser Tyr Gly  Leu Tyr Leu Asp Gly  Ile Leu Ile 
    2270                 2275                 2280             


His Asn  Ser Ser Glu Leu Ser  Tyr Arg Ala Tyr Gly  Phe Ala Pro 
    2285                 2290                 2295             


Trp Ser  Leu His Ser Phe Arg  Val Gln Ala Cys Thr  Ala Lys Gly 
    2300                 2305                 2310             


Cys Ala  Leu Gly Pro Leu Val  Glu Asn Arg Thr Leu  Glu Ala Pro 
    2315                 2320                 2325             


Pro Glu  Gly Thr Val Asn Val  Phe Val Lys Thr Gln  Gly Ser Arg 
    2330                 2335                 2340             


Lys Ala  His Val Arg Trp Glu  Ala Pro Phe Arg Pro  Asn Gly Leu 
    2345                 2350                 2355             


Leu Thr  His Ser Val Leu Phe  Thr Gly Ile Phe Tyr  Val Asp Pro 
    2360                 2365                 2370             


Val Gly  Asn Asn Tyr Thr Leu  Leu Asn Val Thr Lys  Val Met Tyr 
    2375                 2380                 2385             


Ser Gly  Glu Glu Thr Asn Leu  Trp Val Leu Ile Asp  Gly Leu Val 
    2390                 2395                 2400             


Pro Phe  Thr Asn Tyr Thr Val  Gln Val Asn Ile Ser  Asn Ser Gln 
    2405                 2410                 2415             


Gly Ser  Leu Ile Thr Asp Pro  Ile Thr Ile Ala Met  Pro Pro Gly 
    2420                 2425                 2430             


Ala Pro  Asp Gly Val Leu Pro  Pro Arg Leu Ser Ser  Ala Thr Pro 
    2435                 2440                 2445             


Thr Ser  Leu Gln Val Val Trp  Ser Thr Pro Ala Arg  Asn Asn Ala 
    2450                 2455                 2460             


Pro Gly  Ser Pro Arg Tyr Gln  Leu Gln Met Arg Ser  Gly Asp Ser 
    2465                 2470                 2475             


Thr His  Gly Phe Leu Glu Leu  Phe Ser Asn Pro Ser  Ala Ser Leu 
    2480                 2485                 2490             


Ser Tyr  Glu Val Ser Asp Leu  Gln Pro Tyr Thr Glu  Tyr Met Phe 
    2495                 2500                 2505             


Arg Leu  Val Ala Ser Asn Gly  Phe Gly Ser Ala His  Ser Ser Trp 
    2510                 2515                 2520             


Ile Pro  Phe Met Thr Ala Glu  Asp Lys Pro Gly Pro  Val Val Pro 
    2525                 2530                 2535             


Pro Ile  Leu Leu Asp Val Lys  Ser Arg Met Met Leu  Val Thr Trp 
    2540                 2545                 2550             


Gln His  Pro Arg Lys Ser Asn  Gly Val Ile Thr His  Tyr Asn Ile 
    2555                 2560                 2565             


Tyr Leu  His Gly Arg Leu Tyr  Leu Arg Thr Pro Gly  Asn Val Thr 
    2570                 2575                 2580             


Asn Cys  Thr Val Met His Leu  His Pro Tyr Thr Ala  Tyr Lys Phe 
    2585                 2590                 2595             


Gln Val  Glu Ala Cys Thr Ser  Lys Gly Cys Ser Leu  Ser Pro Glu 
    2600                 2605                 2610             


Ser Gln  Thr Val Trp Thr Leu  Pro Gly Ala Pro Glu  Gly Ile Pro 
    2615                 2620                 2625             


Ser Pro  Glu Leu Phe Ser Asp  Thr Pro Thr Ser Val  Ile Ile Ser 
    2630                 2635                 2640             


Trp Gln  Pro Pro Thr His Pro  Asn Gly Leu Val Glu  Asn Phe Thr 
    2645                 2650                 2655             


Ile Glu  Arg Arg Val Lys Gly  Lys Glu Glu Val Thr  Thr Leu Val 
    2660                 2665                 2670             


Thr Leu  Pro Arg Ser His Ser  Met Arg Phe Ile Asp  Lys Thr Ser 
    2675                 2680                 2685             


Ala Leu  Ser Pro Trp Thr Lys  Tyr Glu Tyr Arg Val  Leu Met Ser 
    2690                 2695                 2700             


Thr Leu  His Gly Gly Thr Asn  Ser Ser Ala Trp Val  Glu Val Thr 
    2705                 2710                 2715             


Thr Arg  Pro Ser Arg Pro Ala  Gly Val Gln Pro Pro  Val Val Thr 
    2720                 2725                 2730             


Val Leu  Glu Pro Asp Ala Val  Gln Val Thr Trp Lys  Pro Pro Leu 
    2735                 2740                 2745             


Ile Gln  Asn Gly Asp Ile Leu  Ser Tyr Glu Ile His  Met Pro Asp 
    2750                 2755                 2760             


Pro His  Ile Thr Leu Thr Asn  Val Thr Ser Ala Val  Leu Ser Gln 
    2765                 2770                 2775             


Lys Val  Thr His Leu Ile Pro  Phe Thr Asn Tyr Ser  Val Thr Ile 
    2780                 2785                 2790             


Val Ala  Cys Ser Gly Gly Asn  Gly Tyr Leu Gly Gly  Cys Thr Glu 
    2795                 2800                 2805             


Ser Leu  Pro Thr Tyr Val Thr  Thr His Pro Thr Val  Pro Gln Asn 
    2810                 2815                 2820             


Val Gly  Pro Leu Ser Val Ile  Pro Leu Ser Glu Ser  Tyr Val Val 
    2825                 2830                 2835             


Ile Ser  Trp Gln Pro Pro Ser  Lys Pro Asn Gly Pro  Asn Leu Arg 
    2840                 2845                 2850             


Tyr Glu  Leu Leu Arg Arg Lys  Ile Gln Gln Pro Leu  Ala Ser Asn 
    2855                 2860                 2865             


Pro Pro  Glu Asp Leu Asn Arg  Trp His Asn Ile Tyr  Ser Gly Thr 
    2870                 2875                 2880             


Gln Trp  Leu Tyr Glu Asp Lys  Gly Leu Ser Arg Phe  Thr Thr Tyr 
    2885                 2890                 2895             


Glu Tyr  Met Leu Phe Val His  Asn Ser Val Gly Phe  Thr Pro Ser 
    2900                 2905                 2910             


Arg Glu  Val Thr Val Thr Thr  Leu Ala Gly Leu Pro  Glu Arg Gly 
    2915                 2920                 2925             


Ala Asn  Leu Thr Ala Ser Val  Leu Asn His Thr Ala  Ile Asp Val 
    2930                 2935                 2940             


Arg Trp  Ala Lys Pro Thr Val  Gln Asp Leu Gln Gly  Glu Val Glu 
    2945                 2950                 2955             


Tyr Tyr  Thr Leu Phe Trp Ser  Ser Ala Thr Ser Asn  Asp Ser Leu 
    2960                 2965                 2970             


Lys Ile  Leu Pro Asp Val Asn  Ser His Val Ile Gly  His Leu Lys 
    2975                 2980                 2985             


Pro Asn  Thr Glu Tyr Trp Ile  Phe Ile Ser Val Phe  Asn Gly Val 
    2990                 2995                 3000             


His Ser  Ile Asn Ser Ala Gly  Leu His Ala Thr Thr  Cys Asp Gly 
    3005                 3010                 3015             


Glu Pro  Gln Gly Met Leu Pro  Pro Glu Val Val Ile  Ile Asn Ser 
    3020                 3025                 3030             


Thr Ala  Val Arg Val Ile Trp  Thr Ser Pro Ser Asn  Pro Asn Gly 
    3035                 3040                 3045             


Val Val  Thr Glu Tyr Ser Ile  Tyr Val Asn Asn Lys  Leu Tyr Lys 
    3050                 3055                 3060             


Thr Gly  Met Asn Val Pro Gly  Ser Phe Ile Leu Arg  Asp Leu Ser 
    3065                 3070                 3075             


Pro Phe  Thr Ile Tyr Asp Ile  Gln Val Glu Val Cys  Thr Ile Tyr 
    3080                 3085                 3090             


Ala Cys  Val Lys Ser Asn Gly  Thr Gln Ile Thr Thr  Val Glu Asp 
    3095                 3100                 3105             


Thr Pro  Ser Asp Ile Pro Thr  Pro Thr Ile Arg Gly  Ile Thr Ser 
    3110                 3115                 3120             


Arg Ser  Leu Gln Ile Asp Trp  Val Ser Pro Arg Lys  Pro Asn Gly 
    3125                 3130                 3135             


Ile Ile  Leu Gly Tyr Asp Leu  Leu Trp Lys Thr Trp  Tyr Pro Cys 
    3140                 3145                 3150             


Ala Lys  Thr Gln Lys Leu Val  Gln Asp Gln Ser Asp  Glu Leu Cys 
    3155                 3160                 3165             


Lys Ala  Val Arg Cys Gln Lys  Pro Glu Ser Ile Cys  Gly His Ile 
    3170                 3175                 3180             


Cys Tyr  Ser Ser Glu Ala Lys  Val Cys Cys Asn Gly  Val Leu Tyr 
    3185                 3190                 3195             


Asn Pro  Lys Pro Gly His Arg  Cys Cys Glu Glu Lys  Tyr Ile Pro 
    3200                 3205                 3210             


Phe Val  Leu Asn Ser Thr Gly  Val Cys Cys Gly Gly  Arg Ile Gln 
    3215                 3220                 3225             


Glu Ala  Gln Pro Asn His Gln  Cys Cys Ser Gly Tyr  Tyr Ala Arg 
    3230                 3235                 3240             


Ile Leu  Pro Gly Glu Val Cys  Cys Pro Asp Glu Gln  His Asn Arg 
    3245                 3250                 3255             


Val Ser  Val Gly Ile Gly Asp  Ser Cys Cys Gly Arg  Met Pro Tyr 
    3260                 3265                 3270             


Ser Thr  Ser Gly Asn Gln Ile  Cys Cys Ala Gly Arg  Leu His Asp 
    3275                 3280                 3285             


Gly His  Gly Gln Lys Cys Cys  Gly Arg Gln Ile Val  Ser Asn Asp 
    3290                 3295                 3300             


Leu Glu  Cys Cys Gly Gly Glu  Glu Gly Val Val Tyr  Asn Arg Leu 
    3305                 3310                 3315             


Pro Gly  Met Phe Cys Cys Gly  Gln Asp Tyr Val Asn  Met Ser Asp 
    3320                 3325                 3330             


Thr Ile  Cys Cys Ser Ala Ser  Ser Gly Glu Ser Lys  Ala His Ile 
    3335                 3340                 3345             


Lys Lys  Asn Asp Pro Val Pro  Val Lys Cys Cys Glu  Thr Glu Leu 
    3350                 3355                 3360             


Ile Pro  Lys Ser Gln Lys Cys  Cys Asn Gly Val Gly  Tyr Asn Pro 
    3365                 3370                 3375             


Leu Lys  Tyr Val Cys Ser Asp  Lys Ile Ser Thr Gly  Met Met Met 
    3380                 3385                 3390             


Lys Glu  Thr Lys Glu Cys Arg  Ile Leu Cys Pro Ala  Ser Met Glu 
    3395                 3400                 3405             


Ala Thr  Glu His Cys Gly Arg  Cys Asp Phe Asn Phe  Thr Ser His 
    3410                 3415                 3420             


Ile Cys  Thr Val Ile Arg Gly  Ser His Asn Ser Thr  Gly Lys Ala 
    3425                 3430                 3435             


Ser Ile  Glu Glu Met Cys Ser  Ser Ala Glu Glu Thr  Ile His Thr 
    3440                 3445                 3450             


Gly Ser  Val Asn Thr Tyr Ser  Tyr Thr Asp Val Asn  Leu Lys Pro 
    3455                 3460                 3465             


Tyr Met  Thr Tyr Glu Tyr Arg  Ile Ser Ala Trp Asn  Ser Tyr Gly 
    3470                 3475                 3480             


Arg Gly  Leu Ser Lys Ala Val  Arg Ala Arg Thr Lys  Glu Asp Val 
    3485                 3490                 3495             


Pro Gln  Gly Val Ser Pro Pro  Thr Trp Thr Lys Ile  Asp Asn Leu 
    3500                 3505                 3510             


Glu Asp  Thr Ile Val Leu Asn  Trp Arg Lys Pro Ile  Gln Ser Asn 
    3515                 3520                 3525             


Gly Pro  Ile Ile Tyr Tyr Ile  Leu Leu Arg Asn Gly  Ile Glu Arg 
    3530                 3535                 3540             


Phe Arg  Gly Thr Ser Leu Ser  Phe Ser Asp Lys Glu  Gly Ile Gln 
    3545                 3550                 3555             


Pro Phe  Gln Glu Tyr Ser Tyr  Gln Leu Lys Ala Cys  Thr Val Ala 
    3560                 3565                 3570             


Gly Cys  Ala Thr Ser Ser Lys  Val Val Ala Ala Thr  Thr Gln Gly 
    3575                 3580                 3585             


Val Pro  Glu Ser Ile Leu Pro  Pro Ser Ile Thr Ala  Leu Ser Ala 
    3590                 3595                 3600             


Val Ala  Leu His Leu Ser Trp  Ser Val Pro Glu Lys  Ser Asn Gly 
    3605                 3610                 3615             


Val Ile  Lys Glu Tyr Gln Ile  Arg Gln Val Gly Lys  Gly Leu Ile 
    3620                 3625                 3630             


His Thr  Asp Thr Thr Asp Arg  Arg Gln His Thr Val  Thr Gly Leu 
    3635                 3640                 3645             


Gln Pro  Tyr Thr Asn Tyr Ser  Phe Thr Leu Thr Ala  Cys Thr Ser 
    3650                 3655                 3660             


Ala Gly  Cys Thr Ser Ser Glu  Pro Phe Leu Gly Gln  Thr Leu Gln 
    3665                 3670                 3675             


Ala Ala  Pro Glu Gly Val Trp  Val Thr Pro Arg His  Ile Ile Ile 
    3680                 3685                 3690             


Asn Ser  Thr Thr Val Glu Leu  Tyr Trp Ser Leu Pro  Glu Lys Pro 
    3695                 3700                 3705             


Asn Gly  Leu Val Ser Gln Tyr  Gln Leu Ser Arg Asn  Gly Asn Leu 
    3710                 3715                 3720             


Leu Phe  Leu Gly Gly Ser Glu  Glu Gln Asn Phe Thr  Asp Lys Asn 
    3725                 3730                 3735             


Leu Glu  Pro Asn Ser Arg Tyr  Thr Tyr Lys Leu Glu  Val Lys Thr 
    3740                 3745                 3750             


Gly Gly  Gly Ser Ser Ala Ser  Asp Asp Tyr Ile Val  Gln Thr Pro 
    3755                 3760                 3765             


Met Ser  Thr Pro Glu Glu Ile  Tyr Pro Pro Tyr Asn  Ile Thr Val 
    3770                 3775                 3780             


Ile Gly  Pro Tyr Ser Ile Phe  Val Ala Trp Ile Pro  Pro Gly Ile 
    3785                 3790                 3795             


Leu Ile  Pro Glu Ile Pro Val  Glu Tyr Asn Val Leu  Leu Asn Asp 
    3800                 3805                 3810             


Gly Ser  Val Thr Pro Leu Ala  Phe Ser Val Gly His  His Gln Ser 
    3815                 3820                 3825             


Thr Leu  Leu Glu Asn Leu Thr  Pro Phe Thr Gln Tyr  Glu Ile Arg 
    3830                 3835                 3840             


Ile Gln  Ala Cys Gln Asn Gly  Ser Cys Gly Val Ser  Ser Arg Met 
    3845                 3850                 3855             


Phe Val  Lys Thr Pro Glu Ala  Ala Pro Met Asp Leu  Asn Ser Pro 
    3860                 3865                 3870             


Val Leu  Lys Ala Leu Gly Ser  Ala Cys Ile Glu Ile  Lys Trp Met 
    3875                 3880                 3885             


Pro Pro  Glu Lys Pro Asn Gly  Ile Ile Ile Asn Tyr  Phe Ile Tyr 
    3890                 3895                 3900             


Arg Arg  Pro Ala Gly Ile Glu  Glu Glu Ser Val Leu  Phe Val Trp 
    3905                 3910                 3915             


Ser Glu  Gly Ala Leu Glu Phe  Met Asp Glu Gly Asp  Thr Leu Arg 
    3920                 3925                 3930             


Pro Phe  Thr Leu Tyr Glu Tyr  Arg Val Arg Ala Cys  Asn Ser Lys 
    3935                 3940                 3945             


Gly Ser  Val Glu Ser Leu Trp  Ser Leu Thr Gln Thr  Leu Glu Ala 
    3950                 3955                 3960             


Pro Pro  Gln Asp Phe Pro Ala  Pro Trp Ala Gln Ala  Thr Ser Ala 
    3965                 3970                 3975             


His Ser  Val Leu Leu Asn Trp  Thr Lys Pro Glu Ser  Pro Asn Gly 
    3980                 3985                 3990             


Ile Ile  Ser His Tyr Arg Val  Val Tyr Gln Glu Arg  Pro Asp Asp 
    3995                 4000                 4005             


Pro Thr  Phe Asn Ser Pro Thr  Val His Ala Phe Thr  Val Lys Gly 
    4010                 4015                 4020             


Thr Ser  His Gln Ala His Leu  Tyr Gly Leu Glu Pro  Phe Thr Thr 
    4025                 4030                 4035             


Tyr Arg  Ile Gly Val Val Ala  Ala Asn His Ala Gly  Glu Ile Leu 
    4040                 4045                 4050             


Ser Pro  Trp Thr Leu Ile Gln  Thr Leu Glu Ser Ser  Pro Ser Gly 
    4055                 4060                 4065             


Leu Arg  Asn Phe Ile Val Glu  Gln Lys Glu Asn Gly  Arg Ala Leu 
    4070                 4075                 4080             


Leu Leu  Gln Trp Ser Glu Pro  Met Arg Thr Asn Gly  Val Ile Lys 
    4085                 4090                 4095             


Thr Tyr  Asn Ile Phe Ser Asp  Gly Phe Leu Glu Tyr  Ser Gly Leu 
    4100                 4105                 4110             


Asn Arg  Gln Phe Leu Phe Arg  Arg Leu Asp Pro Phe  Thr Leu Tyr 
    4115                 4120                 4125             


Thr Leu  Thr Leu Glu Ala Cys  Thr Arg Ala Gly Cys  Ala His Ser 
    4130                 4135                 4140             


Ala Pro  Gln Pro Leu Trp Thr  Asp Glu Ala Pro Pro  Asp Ser Gln 
    4145                 4150                 4155             


Leu Ala  Pro Thr Val His Ser  Val Lys Ser Thr Ser  Val Glu Leu 
    4160                 4165                 4170             


Ser Trp  Ser Glu Pro Val Asn  Pro Asn Gly Lys Ile  Ile Arg Tyr 
    4175                 4180                 4185             


Glu Val  Ile Arg Arg Cys Phe  Glu Gly Lys Ala Trp  Gly Asn Gln 
    4190                 4195                 4200             


Thr Ile  Gln Ala Asp Glu Lys  Ile Val Phe Thr Glu  Tyr Asn Thr 
    4205                 4210                 4215             


Glu Arg  Asn Thr Phe Met Tyr  Asn Asp Thr Gly Leu  Gln Pro Trp 
    4220                 4225                 4230             


Thr Gln  Cys Glu Tyr Lys Ile  Tyr Thr Trp Asn Ser  Ala Gly His 
    4235                 4240                 4245             


Thr Cys  Ser Ser Trp Asn Val  Val Arg Thr Leu Gln  Ala Pro Pro 
    4250                 4255                 4260             


Glu Gly  Leu Ser Pro Pro Val  Ile Ser Tyr Val Ser  Met Asn Pro 
    4265                 4270                 4275             


Gln Lys  Leu Leu Ile Ser Trp  Ile Pro Pro Glu Gln  Ser Asn Gly 
    4280                 4285                 4290             


Ile Ile  Gln Ser Tyr Arg Leu  Gln Arg Asn Glu Met  Leu Tyr Pro 
    4295                 4300                 4305             


Phe Ser  Phe Asp Pro Val Thr  Phe Asn Tyr Thr Asp  Glu Glu Leu 
    4310                 4315                 4320             


Leu Pro  Phe Ser Thr Tyr Ser  Tyr Ala Leu Gln Ala  Cys Thr Ser 
    4325                 4330                 4335             


Gly Gly  Cys Ser Thr Ser Lys  Pro Thr Ser Ile Thr  Thr Leu Glu 
    4340                 4345                 4350             


Ala Ala  Pro Ser Glu Val Ser  Pro Pro Asp Leu Trp  Ala Val Ser 
    4355                 4360                 4365             


Ala Thr  Gln Met Asn Val Cys  Trp Ser Pro Pro Thr  Val Gln Asn 
    4370                 4375                 4380             


Gly Lys  Ile Thr Lys Tyr Leu  Val Arg Tyr Asp Asn  Lys Glu Ser 
    4385                 4390                 4395             


Leu Ala  Gly Gln Gly Leu Cys  Leu Leu Val Ser His  Leu Gln Pro 
    4400                 4405                 4410             


Tyr Ser  Gln Tyr Asn Phe Ser  Leu Val Ala Cys Thr  Asn Gly Gly 
    4415                 4420                 4425             


Cys Thr  Ala Ser Val Ser Lys  Ser Ala Trp Thr Met  Glu Ala Leu 
    4430                 4435                 4440             


Pro Glu  Asn Met Asp Ser Pro  Thr Leu Gln Val Thr  Gly Ser Glu 
    4445                 4450                 4455             


Ser Ile  Glu Ile Thr Trp Lys  Pro Pro Arg Asn Pro  Asn Gly Gln 
    4460                 4465                 4470             


Ile Arg  Ser Tyr Glu Leu Arg  Arg Asp Gly Thr Ile  Val Tyr Thr 
    4475                 4480                 4485             


Gly Leu  Glu Thr Arg Tyr Arg  Asp Phe Thr Leu Thr  Pro Gly Val 
    4490                 4495                 4500             


Glu Tyr  Ser Tyr Thr Val Thr  Ala Ser Asn Ser Gln  Gly Gly Ile 
    4505                 4510                 4515             


Leu Ser  Pro Leu Val Lys Asp  Arg Thr Ser Pro Ser  Ala Pro Ser 
    4520                 4525                 4530             


Gly Met  Glu Pro Pro Lys Leu  Gln Ala Arg Gly Pro  Gln Glu Ile 
    4535                 4540                 4545             


Leu Val  Asn Trp Asp Pro Pro  Val Arg Thr Asn Gly  Asp Ile Ile 
    4550                 4555                 4560             


Asn Tyr  Thr Leu Phe Ile Arg  Glu Leu Phe Glu Arg  Glu Thr Lys 
    4565                 4570                 4575             


Ile Ile  His Ile Asn Thr Thr  His Asn Ser Phe Gly  Met Gln Ser 
    4580                 4585                 4590             


Tyr Ile  Val Asn Gln Leu Lys  Pro Phe His Arg Tyr  Glu Ile Arg 
    4595                 4600                 4605             


Ile Gln  Ala Cys Thr Thr Leu  Gly Cys Ala Ser Ser  Asp Trp Thr 
    4610                 4615                 4620             


Phe Ile  Gln Thr Pro Glu Ile  Ala Pro Leu Met Gln  Pro Pro Pro 
    4625                 4630                 4635             


His Leu  Glu Val Gln Met Ala  Pro Gly Gly Phe Gln  Pro Thr Val 
    4640                 4645                 4650             


Ser Leu  Leu Trp Thr Gly Pro  Leu Gln Pro Asn Gly  Lys Val Leu 
    4655                 4660                 4665             


Tyr Tyr  Glu Leu Tyr Arg Arg  Gln Ile Ala Thr Gln  Pro Arg Lys 
    4670                 4675                 4680             


Ser Asn  Pro Val Leu Ile Tyr  Asn Gly Ser Ser Thr  Ser Phe Ile 
    4685                 4690                 4695             


Asp Ser  Glu Leu Leu Pro Phe  Thr Glu Tyr Glu Tyr  Gln Val Trp 
    4700                 4705                 4710             


Ala Val  Asn Ser Ala Gly Lys  Ala Pro Ser Ser Trp  Thr Trp Cys 
    4715                 4720                 4725             


Arg Thr  Gly Pro Ala Pro Pro  Glu Gly Leu Arg Ala  Pro Thr Phe 
    4730                 4735                 4740             


His Val  Ile Ser Ser Thr Gln  Ala Val Val Asn Ile  Ser Ala Pro 
    4745                 4750                 4755             


Gly Lys  Pro Asn Gly Ile Val  Ser Leu Tyr Arg Leu  Phe Ser Ser 
    4760                 4765                 4770             


Ser Ala  His Gly Ala Glu Thr  Val Leu Ser Glu Gly  Met Ala Thr 
    4775                 4780                 4785             


Gln Gln  Thr Leu His Gly Leu  Gln Ala Phe Thr Asn  Tyr Ser Ile 
    4790                 4795                 4800             


Gly Val  Glu Ala Cys Thr Cys  Phe Asn Cys Cys Ser  Lys Gly Pro 
    4805                 4810                 4815             


Thr Ala  Glu Leu Arg Thr His  Pro Ala Pro Pro Ser  Gly Leu Ser 
    4820                 4825                 4830             


Ser Pro  Gln Ile Gly Thr Leu  Ala Ser Arg Thr Ala  Ser Phe Arg 
    4835                 4840                 4845             


Trp Ser  Pro Pro Met Phe Pro  Asn Gly Val Ile His  Ser Tyr Glu 
    4850                 4855                 4860             


Leu Gln  Phe His Val Ala Cys  Pro Pro Asp Ser Ala  Leu Pro Cys 
    4865                 4870                 4875             


Thr Pro  Ser Gln Ile Glu Thr  Lys Tyr Thr Gly Leu  Gly Gln Lys 
    4880                 4885                 4890             


Ala Ser  Leu Gly Gly Leu Gln  Pro Tyr Thr Thr Tyr  Lys Leu Arg 
    4895                 4900                 4905             


Val Val  Ala His Asn Glu Val  Gly Ser Thr Ala Ser  Glu Trp Ile 
    4910                 4915                 4920             


Ser Phe  Thr Thr Gln Lys Glu  Leu Pro Gln Tyr Arg  Ala Pro Phe 
    4925                 4930                 4935             


Ser Val  Asp Ser Asn Leu Ser  Val Val Cys Val Asn  Trp Ser Asp 
    4940                 4945                 4950             


Thr Phe  Leu Leu Asn Gly Gln  Leu Lys Glu Tyr Val  Leu Thr Asp 
    4955                 4960                 4965             


Gly Gly  Arg Arg Val Tyr Ser  Gly Leu Asp Thr Thr  Leu Tyr Ile 
    4970                 4975                 4980             


Pro Arg  Thr Ala Asp Lys Thr  Phe Phe Phe Gln Val  Ile Cys Thr 
    4985                 4990                 4995             


Thr Asp  Glu Gly Ser Val Lys  Thr Pro Leu Ile Gln  Tyr Asp Thr 
    5000                 5005                 5010             


Ser Thr  Gly Leu Gly Leu Val  Leu Thr Thr Pro Gly  Lys Lys Lys 
    5015                 5020                 5025             


Gly Ser  Arg Ser Lys Ser Thr  Glu Phe Tyr Ser Glu  Leu Trp Phe 
    5030                 5035                 5040             


Ile Val  Leu Met Ala Met Leu  Gly Leu Ile Leu Leu  Ala Ile Phe 
    5045                 5050                 5055             


Leu Ser  Leu Ile Leu Gln Arg  Lys Ile His Lys Glu  Pro Tyr Ile 
    5060                 5065                 5070             


Arg Glu  Arg Pro Pro Leu Val  Pro Leu Gln Lys Arg  Met Ser Pro 
    5075                 5080                 5085             


Leu Asn  Val Tyr Pro Pro Gly  Glu Asn His Met Gly  Leu Ala Asp 
    5090                 5095                 5100             


Thr Lys  Ile Pro Arg Ser Gly  Thr Pro Val Ser Ile  Arg Ser Asn 
    5105                 5110                 5115             


Arg Ser  Ala Cys Val Leu Arg  Ile Pro Ser Gln Asn  Gln Thr Ser 
    5120                 5125                 5130             


Leu Thr  Tyr Ser Gln Gly Ser  Leu His Arg Ser Val  Ser Gln Leu 
    5135                 5140                 5145             


Met Asp  Ile Gln Asp Lys Lys  Val Leu Met Asp Asn  Ser Leu Trp 
    5150                 5155                 5160             


Glu Ala  Ile Met Gly His Asn  Ser Gly Leu Tyr Val  Asp Glu Glu 
    5165                 5170                 5175             


Asp Leu  Met Asn Ala Ile Lys  Asp Phe Ser Ser Val  Thr Lys Glu 
    5180                 5185                 5190             


Arg Thr  Thr Phe Thr Asp Thr  His Leu 
    5195                 5200         


<210>  413
<211>  1368
<212>  DNA
<213>  Homosapiens

<400>  413
cagaaaaatg gcagccgccg ctccggactc acgtgtgagt gaggaagaaa acctgaaaaa     60

gaccccaaag aagaagatga aaatggtaac tggagccgta gcgtcggtgc tggaagacga    120

ggccacagac acttctgata gtgaaggaag ctgtggatcg gaaaaggacc acttttattc    180

tgatgatgac gcaatagaag ctgacagtga gggtgatgct gagccctgtg acaaagaaaa    240

tgaaaatgat ggagaatcaa gtgttgggac taatatgggc tgggcagatg ctatggctaa    300

agtcctcaac aagaaaactc ctgaaagtaa acctactatt ctggtcaaaa ataagaagct    360

ggaaaaggaa aaagaaaagt taaagcaaga aagactagag aaaataaaac agcgtgataa    420

gaggctggag tgggaaatga tgtgcagagt aaagccagat gttgtccaag acaaagagac    480

agagagaaat cttcagagaa ttgcaacaag gggtgtggtg caattattta atgctgttca    540

gaaacatcaa aagaatgttg atgaaaaggt taaggaagct ggaagttcta tgagaaagcg    600

tgctaagttg atatcaactg tttccaagaa agatttcatc agtgttttga gagggatgga    660

tggaagtaca aatgagactg cttcaagcag gaagaaacca aaagccaaac agactgaagt    720

gaaatcagaa gaaggcccag gttggacgat cctacgtgat gatttcatga tgggagcatc    780

tatgaaagac tgggacaagg aaagtgatgg gccagatgac agcagaccag aatctgcaag    840

tgactctgat acataaagca tcataggaaa tacaattgca gtcgttttat tttttctaga    900

aaaatatgtc atcctctgat agttggggaa ttataaggat accatttgta agaaagccaa    960

aagacttttg ccagatttca tatttcccct tttcatgtac actttatata tacttcatta   1020

aaattatatt ttaaaccctt gtataatttt aagcattgtt cctcagaaca tttgtaaaag   1080

gatatatttc tgcttgacca gcgagatgtg cattttgcca ggatcatatt ggtcatgtct   1140

attggtgtat tatttcagta tcaccaatgt tttcagaaat acagtactaa ttcatcatta   1200

aactctttga agttaatatt tttctgcctt ctaacttata gactcaacta tgtatctgta   1260

gtttttggga atggttggtg ttttttgctt tgtgttggga agttattgag aaaacctata   1320

taataaaatt taaaattata aaaaaaaaaa aaaaaaaaaa aaaaaaaa                1368


<210>  414
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  414

Met Lys Met Val Thr Gly Ala Val Ala Ser Val Leu Glu Asp Glu Ala 
1               5                   10                  15      


Thr Asp Thr Ser Asp Ser Glu Gly Ser Cys Gly Ser Glu Lys Asp His 
            20                  25                  30          


Phe Tyr Ser Asp Asp Asp Ala Ile Glu Ala Asp Ser Glu Gly Asp Ala 
        35                  40                  45              


Glu Pro Cys Asp Lys Glu Asn Glu Asn Asp Gly Glu Ser Ser Val Gly 
    50                  55                  60                  


Thr Asn Met Gly Trp Ala Asp Ala Met Ala Lys Val Leu Asn Lys Lys 
65                  70                  75                  80  


Thr Pro Glu Ser Lys Pro Thr Ile Leu Val Lys Asn Lys Lys Leu Glu 
                85                  90                  95      


Lys Glu Lys Glu Lys Leu Lys Gln Glu Arg Leu Glu Lys Ile Lys Gln 
            100                 105                 110         


Arg Asp Lys Arg Leu Glu Trp Glu Met Met Cys Arg Val Lys Pro Asp 
        115                 120                 125             


Val Val Gln Asp Lys Glu Thr Glu Arg Asn Leu Gln Arg Ile Ala Thr 
    130                 135                 140                 


Arg Gly Val Val Gln Leu Phe Asn Ala Val Gln Lys His Gln Lys Asn 
145                 150                 155                 160 


Val Asp Glu Lys Val Lys Glu Ala Gly Ser Ser Met Arg Lys Arg Ala 
                165                 170                 175     


Lys Leu Ile Ser Thr Val Ser Lys Lys Asp Phe Ile Ser Val Leu Arg 
            180                 185                 190         


Gly Met Asp Gly Ser Thr Asn Glu Thr Ala Ser Ser Arg Lys Lys Pro 
        195                 200                 205             


Lys Ala Lys Gln Thr Glu Val Lys Ser Glu Glu Gly Pro Gly Trp Thr 
    210                 215                 220                 


Ile Leu Arg Asp Asp Phe Met Met Gly Ala Ser Met Lys Asp Trp Asp 
225                 230                 235                 240 


Lys Glu Ser Asp Gly Pro Asp Asp Ser Arg Pro Glu Ser Ala Ser Asp 
                245                 250                 255     


Ser Asp Thr 
            


<210>  415
<211>  498
<212>  DNA
<213>  Homosapiens

<400>  415
atgctctttc gggtcctcac ttccaaggtg acaaaaggaa caatgatcat gccaaaaagg     60

gtggcagcca catgtgtgcc caaggacagg gctattaaga atttctttat tcaaaacaca    120

gtagaggctg cagcaagtgt cttcaatgca tatgtgcttc ccgagctgta tgtgaagcta    180

cattattgtg tgagttgtgc cattcacagc aggaagcctg caagaactga acatctccac    240

ttctatttag acctgcagat gctggcacca aagctcatga ataaaactcc ccagccaggg    300

tgtcgcaagg gctgccgttg tgatccgcag ggggtgaacg caaccgcgac ggctgatcgt    360

ctgtggctgg gttggcgttt ggagcaagag aaggaggagc aggagaagga gggagctgga    420

ggctggaagc gtttgcaagc ggcggcggca gcaacgtgga gtaaccaagc gggtcagcgc    480

gcgcccgcca gggtgtag                                                  498


<210>  416
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  416

Met Leu Phe Arg Val Leu Thr Ser Lys Val Thr Lys Gly Thr Met Ile 
1               5                   10                  15      


Met Pro Lys Arg Val Ala Ala Thr Cys Val Pro Lys Asp Arg Ala Ile 
            20                  25                  30          


Lys Asn Phe Phe Ile Gln Asn Thr Val Glu Ala Ala Ala Ser Val Phe 
        35                  40                  45              


Asn Ala Tyr Val Leu Pro Glu Leu Tyr Val Lys Leu His Tyr Cys Val 
    50                  55                  60                  


Ser Cys Ala Ile His Ser Arg Lys Pro Ala Arg Thr Glu His Leu His 
65                  70                  75                  80  


Phe Tyr Leu Asp Leu Gln Met Leu Ala Pro Lys Leu Met Asn Lys Thr 
                85                  90                  95      


Pro Gln Pro Gly Cys Arg Lys Gly Cys Arg Cys Asp Pro Gln Gly Val 
            100                 105                 110         


Asn Ala Thr Ala Thr Ala Asp Arg Leu Trp Leu Gly Trp Arg Leu Glu 
        115                 120                 125             


Gln Glu Lys Glu Glu Gln Glu Lys Glu Gly Ala Gly Gly Trp Lys Arg 
    130                 135                 140                 


Leu Gln Ala Ala Ala Ala Ala Thr Trp Ser Asn Gln Ala Gly Gln Arg 
145                 150                 155                 160 


Ala Pro Ala Arg Val 
                165 


<210>  417
<211>  1695
<212>  DNA
<213>  Homosapiens

<400>  417
caagcaggat acgtttttct gttgggcatt gactagattg tttgcaaaag tttcgcatca     60

aaaacaaaca acaacaacaa aaaaccaaac aactctcctt gatctatact ttgagaattg    120

ttgatttctt tttttttatt ctgactttta aaaacaactt ttttttccac ttttttaaaa    180

aatgcactac tgtgtgctga gcgcttttct gatcctgcat ctggtcacgg tcgcgctcag    240

cctgtctacc tgcagcacac tcgatatgga ccagttcatg cgcaagagga tcgaggcgat    300

ccgcgggcag atcctgagca agctgaagct caccagtccc ccagaagact atcctgagcc    360

cgaggaagtc cccccggagg tgatttccat ctacaacagc accagggact tgctccagga    420

gaaggcgagc cggagggcgg ccgcctgcga gcgcgagagg agcgacgaag agtactacgc    480

caaggaggtt tacaaaatag acatgccgcc cttcttcccc tccgaaaatg ccatcccgcc    540

cactttctac agaccctact tcagaattgt tcgatttgac gtctcagcaa tggagaagaa    600

tgcttccaat ttggtgaaag cagagttcag agtctttcgt ttgcagaacc caaaagccag    660

agtgcctgaa caacggattg agctatatca gattctcaag tccaaagatt taacatctcc    720

aacccagcgc tacatcgaca gcaaagttgt gaaaacaaga gcagaaggcg aatggctctc    780

cttcgatgta actgatgctg ttcatgaatg gcttcaccat aaagacagga acctgggatt    840

taaaataagc ttacactgtc cctgctgcac ttttgtacca tctaataatt acatcatccc    900

aaataaaagt gaagaactag aagcaagatt tgcaggtatt gatggcacct ccacatatac    960

cagtggtgat cagaaaacta taaagtccac taggaaaaaa aacagtggga agaccccaca   1020

tctcctgcta atgttattgc cctcctacag acttgagtca caacagacca accggcggaa   1080

gaagcgtgct ttggatgcgg cctattgctt tagaaatgtg caggataatt gctgcctacg   1140

tccactttac attgatttca agagggatct agggtggaaa tggatacacg aacccaaagg   1200

gtacaatgcc aacttctgtg ctggagcatg cccgtattta tggagttcag acactcagca   1260

cagcagggtc ctgagcttat ataataccat aaatccagaa gcatctgctt ctccttgctg   1320

cgtgtcccaa gatttagaac ctctaaccat tctctactac attggcaaaa cacccaagat   1380

tgaacagctt tctaatatga ttgtaaagtc ttgcaaatgc agctaaaatt cttggaaaag   1440

tggcaagacc aaaatgacaa tgatgatgat aatgatgatg acgacgacaa cgatgatgct   1500

tgtaacaaga aaacataaga gagccttggt tcatcagtgt taaaaaattt ttgaaaaggc   1560

ggtactagtt cagacacttt ggaagtttgt gttctgtttg ttaaaactgg catctgacac   1620

aaaaaaagtt gaaggcctta ttctacattt cacctacttt gtaagtgaga gagacaagaa   1680

gcaaattttt ttaaa                                                    1695


<210>  418
<211>  414
<212>  PRT
<213>  Homosapiens

<400>  418

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 
        355                 360                 365             


Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                 375                 380                 


Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile 
385                 390                 395                 400 


Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410                 


<210>  419
<211>  845
<212>  DNA
<213>  Homosapiens

<400>  419
ggggggcatc agcgatggcg gctgcgtcgg ggtcggttct gcagcgctgt atcgtgtcgc     60

cggcagggag gcatagcgcc tctctgatct tcctgcatgg ctcaggtgat tctggacaag    120

gattaagaat gtggatcaag caggttttaa atcaagattt aacattccaa cacataaaaa    180

ttatttatcc aacagctcct cccagatcat atactcctat gaaaggagga atctccaatg    240

tatggtttga cagatttaaa ataaccaatg actgcccaga acaccttgaa tcaattgatg    300

tcatgtgtca agtgcttact gatttgattg atgaagaagt aaaaagtggc atcaagaaga    360

acaggatatt aataggagga ttctctatgg gaggatgcat ggcaatgcat ttagcatata    420

gaaatcatca agatgtggca ggagtatttg ctctttctag ttttctgaat aaagcatctg    480

ctgtttacca ggctcttcag aagagtaatg gtgtacttcc tgaattattt cagtgtcatg    540

gtactgcaga tgagttagtt cttcattctt gggcagaaga gacaaactca atgttaaaat    600

ctctaggagt gaccacgaag tttcatagtt ttccaaatgt ttaccatgag ctaagcaaaa    660

ctgagttaga catattgaag ttatggattc ttacaaagct gccaggagaa atggaaaaac    720

aaaaatgaat gaatcaagag tgatttgtta atgtaagtgt aatgtctttg tgaaaagtga    780

tttttactgc caaattataa tgataattaa aatattaaaa aaaaaaaaaa aaaaaaaaaa    840

aaaaa                                                                845


<210>  420
<211>  237
<212>  PRT
<213>  Homosapiens

<400>  420

Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro 
1               5                   10                  15      


Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp 
            20                  25                  30          


Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp 
        35                  40                  45              


Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg 
    50                  55                  60                  


Ser Tyr Thr Pro Met Lys Gly Gly Ile Ser Asn Val Trp Phe Asp Arg 
65                  70                  75                  80  


Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val 
                85                  90                  95      


Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly 
            100                 105                 110         


Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys 
        115                 120                 125             


Met Ala Met His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val 
    130                 135                 140                 


Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala 
145                 150                 155                 160 


Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly 
                165                 170                 175     


Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser 
            180                 185                 190         


Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn 
        195                 200                 205             


Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp 
    210                 215                 220                 


Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
225                 230                 235         


<210>  421
<211>  1128
<212>  DNA
<213>  Homosapiens

<400>  421
atggtgcagg tttgcggcct catctggtgg actttctggc acagcccttc ttcaaggttg     60

ctgcatctga agctctttaa gacggccttt cccttctgcc agattgcaca ctgtgcacag    120

tgcagttgct tctccctgcg gagtgagatg ggcccacatt ggctgtggct ccacctggcc    180

ttggtgctct tgtcgccctc tgctctgctg ctcccttcat gtaagaagga tgtgttaaga    240

gtccgttttt atcatgaaaa atgtatctat gtccataaag aaagcacaaa agaaaggcat    300

ggctattgca ccttgggaga agcctttaat cggttagact tctcaagtgc aattcaagat    360

atccgaaggt tcaattatgt ggtcaaactt gaaggtgtgc ctgtttgctg tgaattaatc    420

gaaaaacaga agggaacaag ttcaggagaa aacagtgagg ttggaggatt tctccattac    480

cagtttaacc tgaaatgtaa tcttgtcaac tatgaacacg gcccttctca cctctatgct    540

tattttcggc tggagaaaca gtgtccatca gactggatgt cagtgaatct ctacagcgtc    600

agctgtgtgg ctgagggtga tggagcagag tgtgagtgga gggcagagga gaaaaaaaag    660

gcagcctcag agggggccga ccctacccag gatgagcggc gccaggtagc cggggacgct    720

cccggggatc cccgggccct ggctggggga ggcgttgtgg ggcgcacgta cccaggctca    780

gatgaggcga gtgggcggcc ggggctgcag ctggcgctgg ccattgagga gcttctgcgc    840

gacagtgcga tcggttgcac cttctgcgac aggtgccggc cggttggcgc gcagcgcctg    900

ctagcgcaga gtctggccct tgctgcgccc ggccccgaag accgggaagt cgtaaagctc    960

ctcctcgcag cttatgtgcg gcggcggccg ggcagaagcc tagcgacaca gaactgccag   1020

ctcagcagcc ggttacatcc cgcccggcca cccgtaggca gcgtccgctc atgcgcgctc   1080

ctggaagaac cagcagcccc accgcgagtt ccgattggct ctgcgtga                1128


<210>  422
<211>  375
<212>  PRT
<213>  Homosapiens

<400>  422

Met Val Gln Val Cys Gly Leu Ile Trp Trp Thr Phe Trp His Ser Pro 
1               5                   10                  15      


Ser Ser Arg Leu Leu His Leu Lys Leu Phe Lys Thr Ala Phe Pro Phe 
            20                  25                  30          


Cys Gln Ile Ala His Cys Ala Gln Cys Ser Cys Phe Ser Leu Arg Ser 
        35                  40                  45              


Glu Met Gly Pro His Trp Leu Trp Leu His Leu Ala Leu Val Leu Leu 
    50                  55                  60                  


Ser Pro Ser Ala Leu Leu Leu Pro Ser Cys Lys Lys Asp Val Leu Arg 
65                  70                  75                  80  


Val Arg Phe Tyr His Glu Lys Cys Ile Tyr Val His Lys Glu Ser Thr 
                85                  90                  95      


Lys Glu Arg His Gly Tyr Cys Thr Leu Gly Glu Ala Phe Asn Arg Leu 
            100                 105                 110         


Asp Phe Ser Ser Ala Ile Gln Asp Ile Arg Arg Phe Asn Tyr Val Val 
        115                 120                 125             


Lys Leu Glu Gly Val Pro Val Cys Cys Glu Leu Ile Glu Lys Gln Lys 
    130                 135                 140                 


Gly Thr Ser Ser Gly Glu Asn Ser Glu Val Gly Gly Phe Leu His Tyr 
145                 150                 155                 160 


Gln Phe Asn Leu Lys Cys Asn Leu Val Asn Tyr Glu His Gly Pro Ser 
                165                 170                 175     


His Leu Tyr Ala Tyr Phe Arg Leu Glu Lys Gln Cys Pro Ser Asp Trp 
            180                 185                 190         


Met Ser Val Asn Leu Tyr Ser Val Ser Cys Val Ala Glu Gly Asp Gly 
        195                 200                 205             


Ala Glu Cys Glu Trp Arg Ala Glu Glu Lys Lys Lys Ala Ala Ser Glu 
    210                 215                 220                 


Gly Ala Asp Pro Thr Gln Asp Glu Arg Arg Gln Val Ala Gly Asp Ala 
225                 230                 235                 240 


Pro Gly Asp Pro Arg Ala Leu Ala Gly Gly Gly Val Val Gly Arg Thr 
                245                 250                 255     


Tyr Pro Gly Ser Asp Glu Ala Ser Gly Arg Pro Gly Leu Gln Leu Ala 
            260                 265                 270         


Leu Ala Ile Glu Glu Leu Leu Arg Asp Ser Ala Ile Gly Cys Thr Phe 
        275                 280                 285             


Cys Asp Arg Cys Arg Pro Val Gly Ala Gln Arg Leu Leu Ala Gln Ser 
    290                 295                 300                 


Leu Ala Leu Ala Ala Pro Gly Pro Glu Asp Arg Glu Val Val Lys Leu 
305                 310                 315                 320 


Leu Leu Ala Ala Tyr Val Arg Arg Arg Pro Gly Arg Ser Leu Ala Thr 
                325                 330                 335     


Gln Asn Cys Gln Leu Ser Ser Arg Leu His Pro Ala Arg Pro Pro Val 
            340                 345                 350         


Gly Ser Val Arg Ser Cys Ala Leu Leu Glu Glu Pro Ala Ala Pro Pro 
        355                 360                 365             


Arg Val Pro Ile Gly Ser Ala 
    370                 375 


<210>  423
<211>  2923
<212>  DNA
<213>  Homosapiens

<400>  423
aaggaatcaa gcccccaaga tggcggcagc ggcggaggag cggatggcag aggaaggagg     60

cggcggccaa ggcgacggcg gttcctcttt ggcctccggc tctacccagc gacagcctcc    120

accgcccgcg ccacagcacc cgcagccggg gtcccaggcg ctcccagccc ccgcgctggc    180

tccggaccag ctgcctcaaa acaacacgct tgtggcgctg cccatcgtag ccatcgagaa    240

catcctcagc tttatgtcct acgacgaaat tagccagctc cgcctggttt gtaaaagaat    300

ggacttggtc tgccagagaa tgttgaatca gggatttctg aaagtggaga ggtaccataa    360

tctatgtcag aaacaagtta aagcacaact cccaaggaga gagtcagaaa ggagaaacca    420

ttcattagct cgtcatgcag acattcttgc tgctgttgaa acaaggctgt cactattaaa    480

tatgactttc atgaaatatg tggattccaa tctctgttgc ttcatcccag gaaaggtgat    540

tgatgagatt tatcgtgtgt tgagatatgt caattctacc agagcccctc aacgagctca    600

tgaagtactt caagaattaa gggatatatc ctctatggca atggagtact ttgatgaaaa    660

gattgttcca attttaaaga ggaaattacc aggatcagat gtttctggaa gactcatggg    720

ctctcctcca gttccaggac cgtctgcagc cctaacaaca atgcagctct tctccaagca    780

aaatccttca agacaagagg ttaccaaact ccagcagcag gttaaaacaa atggtgctgg    840

cgtgactgtt ctcaggcgtg aaatttctga gcttcgcacc aaagtgcaag aacagcaaaa    900

acagcttcaa gaccaggacc agaaactgct agagcagacc cagatcatag gtgaacaaaa    960

tgcacggttg gcagagctag aacgcaaact acgagaagta atggaaagtg ctgtaggaaa   1020

ttcctcaggg tccgggcaga atgaggagtc tcctcggaaa cgaaaaaagg ccacggaagc   1080

catagactct cttaggaaat ctaaacgtct tcggaataga aagtaaattg gaatgtggtt   1140

ctagttccag aggaagacac agcttagtag cttaagcagt tatgcatatc aggatactgt   1200

gagcaacatg gtgtccctta agcttctagg ctttcagaac acaacttaaa cttgaactct   1260

tatggttggg acattctttt cctgcttctc ctgattgaac tgatgcacag aatcttttta   1320

ctttgcaata gatttgtact aaccagacct gttctatcat gttttgagga gttaactttt   1380

ttctgtgcag ataatgttga aagtaagtta atttgtttct gcatatatgc acatacatac   1440

gtaaggatct taaacccagt cttgacagac tagaagttaa gtttaataca gaaaatgtcc   1500

tgttcacttg aaagaaaaga cctacttttt aaatggacac tatcttggtt cttttttttt   1560

aagtcatctt tttgttataa gtgacctttg tctggaatgt ctgaaaagta gttaatgctt   1620

tttggtattg aagtaatggg taactaaaat ggacttccat agtattgact gtagaaggag   1680

cctctacaat attgactata tatttttata aactactggc aaggaactta cccagctgtt   1740

atacatgttt tcagttctct ttgggggcca tgtcctacat ttgcatggat ggatgcatgc   1800

attgcctagt caactcactt aaaaagctct tgcactggta ttgatcttga acctctatac   1860

ttctccactt tttagagcgg cgtcttagtt tatttaaacg cttaacatct tccaccgcaa   1920

cagcttgcct ctagaggggg aattgttcat ccatttgtcc tccagtttta taggaacaag   1980

agactattaa agcccattgc tttatctgct ctctgtaggg ttcaggtaca ctggctaagg   2040

cagaacccca aatttcaagg ctctttctat caatattgga cctctgggag ctaatactcc   2100

tctttgctca ccaccatgtg atcattgatc agatgtggtg agtgagtagg ggactcgact   2160

tgcgggatgc agttttgcca ttgcagcaaa gttcattgag gaaaattgta ccatgaaaaa   2220

gcattttgat tatttcattt ctggaggatg accttgaggg aagcttttta atattagttt   2280

caagctttcc ttaccctaca actttaaaca aaagctttaa ttttgtttgc actcctattt   2340

tgagcttgta actggaaaag catgtcttgc actgttcaac ctcctgagtg gtcgctttaa   2400

caacctccaa attgtgtaca gtggttattt tccccagttg tatagttttg agacattcaa   2460

ttatcactgt cttagttgta ttttaattta ctaaattatg tagctatctg actgttaagt   2520

tcttttaaac aactgtttcc ttgggcttca gttatttaaa gtaaatttag gtgtaatata   2580

gaaaactgtc cctttccagg tgggagctta acacctgtat aaaacctaag gttttagtaa   2640

gtaccttagt tgaataaaag cacaaggtta tcaccttttt tatccgtcca ccgtgacatg   2700

gttatgcatc ctttagatta acctcaccaa atgaagcttt ttctatccat ttttaatatt   2760

gtccttacat aatattgtcc ttagattttg atcaattcta tgtctgactt tgaaatacca   2820

tttacaatgt agtatgtttt caatgaaaaa ccataaagta acatccaagt gtttcatggt   2880

ttgttgggaa ggtaatttta aaataaaaca atttccaaaa aac                     2923


<210>  424
<211>  368
<212>  PRT
<213>  Homosapiens

<400>  424

Met Ala Ala Ala Ala Glu Glu Arg Met Ala Glu Glu Gly Gly Gly Gly 
1               5                   10                  15      


Gln Gly Asp Gly Gly Ser Ser Leu Ala Ser Gly Ser Thr Gln Arg Gln 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro Gln His Pro Gln Pro Gly Ser Gln Ala Leu 
        35                  40                  45              


Pro Ala Pro Ala Leu Ala Pro Asp Gln Leu Pro Gln Asn Asn Thr Leu 
    50                  55                  60                  


Val Ala Leu Pro Ile Val Ala Ile Glu Asn Ile Leu Ser Phe Met Ser 
65                  70                  75                  80  


Tyr Asp Glu Ile Ser Gln Leu Arg Leu Val Cys Lys Arg Met Asp Leu 
                85                  90                  95      


Val Cys Gln Arg Met Leu Asn Gln Gly Phe Leu Lys Val Glu Arg Tyr 
            100                 105                 110         


His Asn Leu Cys Gln Lys Gln Val Lys Ala Gln Leu Pro Arg Arg Glu 
        115                 120                 125             


Ser Glu Arg Arg Asn His Ser Leu Ala Arg His Ala Asp Ile Leu Ala 
    130                 135                 140                 


Ala Val Glu Thr Arg Leu Ser Leu Leu Asn Met Thr Phe Met Lys Tyr 
145                 150                 155                 160 


Val Asp Ser Asn Leu Cys Cys Phe Ile Pro Gly Lys Val Ile Asp Glu 
                165                 170                 175     


Ile Tyr Arg Val Leu Arg Tyr Val Asn Ser Thr Arg Ala Pro Gln Arg 
            180                 185                 190         


Ala His Glu Val Leu Gln Glu Leu Arg Asp Ile Ser Ser Met Ala Met 
        195                 200                 205             


Glu Tyr Phe Asp Glu Lys Ile Val Pro Ile Leu Lys Arg Lys Leu Pro 
    210                 215                 220                 


Gly Ser Asp Val Ser Gly Arg Leu Met Gly Ser Pro Pro Val Pro Gly 
225                 230                 235                 240 


Pro Ser Ala Ala Leu Thr Thr Met Gln Leu Phe Ser Lys Gln Asn Pro 
                245                 250                 255     


Ser Arg Gln Glu Val Thr Lys Leu Gln Gln Gln Val Lys Thr Asn Gly 
            260                 265                 270         


Ala Gly Val Thr Val Leu Arg Arg Glu Ile Ser Glu Leu Arg Thr Lys 
        275                 280                 285             


Val Gln Glu Gln Gln Lys Gln Leu Gln Asp Gln Asp Gln Lys Leu Leu 
    290                 295                 300                 


Glu Gln Thr Gln Ile Ile Gly Glu Gln Asn Ala Arg Leu Ala Glu Leu 
305                 310                 315                 320 


Glu Arg Lys Leu Arg Glu Val Met Glu Ser Ala Val Gly Asn Ser Ser 
                325                 330                 335     


Gly Ser Gly Gln Asn Glu Glu Ser Pro Arg Lys Arg Lys Lys Ala Thr 
            340                 345                 350         


Glu Ala Ile Asp Ser Leu Arg Lys Ser Lys Arg Leu Arg Asn Arg Lys 
        355                 360                 365             


<210>  425
<211>  2058
<212>  DNA
<213>  Homosapiens

<400>  425
cacagccggc cgacaccaca ccagccgggg agccgccgcc gccgccgcca cctctgagca     60

gccggctggg agcgagagcc gacagctagt ctgcaagcca ccgctgtcgc catggggagc    120

cgcgtctcgc gggaagactt cgagtgggtc tacaccgacc agccgcacgc cgaccggcgc    180

cgggagatcc tggcaaagta tccagagata aagtccttga tgaaacctga tcccaatttg    240

atatggatta taattatgat ggttctcacc cagttgggtg cattttacat agtaaaagac    300

ttggactgga aatgggtcat atttggggcc tatgcgtttg gcagttgcat taaccactca    360

atgactctgg ctattcatga gattgcccac aatgctgcct ttggcaactg caaagcaatg    420

tggaatcgct ggtttggaat gtttgctaat cttcctattg ggattccata ttcaatttcc    480

tttaagaggt atcacatgga tcatcatcgg taccttggag ctgatggcgt cgatgtagat    540

attcctaccg attttgaggg ctggttcttc tgtaccgctt tcagaaagtt tatatgggtt    600

attcttcagc ctctctttta tgcctttcga cctctgttca tcaaccccaa accaattacg    660

tatctggaag ttatcaatac cgtggcacag gtcacttttg acattttaat ttattacttt    720

ttgggaatta aatccttagt ctacatgttg gcagcatctt tacttggcct gggtttgcac    780

ccaatttctg gacattttat agctgagcat tacatgttct taaagggtca tgaaacttac    840

tcatattatg ggcctctgaa tttacttacc ttcaatgtgg gttatcataa tgaacatcat    900

gatttcccca acattcctgg aaaaagtctt ccactggtga ggaaaatagc agctgaatac    960

tatgacaacc tccctcacta caattcctgg ataaaagtac tgtatgattt tgtgatggat   1020

gatacaataa gtccctactc aagaatgaag aggcaccaaa aaggagagat ggtgctggag   1080

taaatatcat tagtgccaaa gggattcttc tccaaaactt tagatgataa aatggaattt   1140

ttgcattatt aaacttgaga ccagtgatgc tcagaagctc ccctggcaca atttcagagt   1200

aagagctcgg tgataccaag aagtgaatct ggcttttaaa cagtcagcct gactctgtac   1260

tgctcagttt cactcacagg aaacttgtga cttgtgtatt atcgtcattg aggatgtttc   1320

actcatgtct gtcattttat aagcatatca tttaaaaagc ttctaaaaag ctatttcgcc   1380

aggcacggtg gctcatgcct ataatcccag cactttggga ggccaaggtg ggtggatcac   1440

ctgaggtcag gagttcgaga ccagcctggc caacacggtg aaaccccatc tctactaaaa   1500

atgcaaaaat tagccgggcg tggcggcaca tgcctgtaat cccagctaca tgggaggctg   1560

aggtgggaga attgcttgaa cccaggaggc ggaggcagag gctgcagtga cccaagattg   1620

tgccactgca ctccaccctg ggcaacagag caagacccca tctcaaaaat aaataaatat   1680

atataaaaaa taaaaagcta tttctagttt atttcactat aaagttttgc tttattaaaa   1740

agctaataaa cagctattaa tcacagtgta ttagtatttg ttacattttt gtatttcact   1800

atctttatac tatataatat ggtaacttgg gtaccggggg aactttaaaa tttcatctca   1860

aaaataattt ttaaaaagcc tgaggtatga tatagcataa aagattgaga tgaaaatata   1920

tttccctgta agctgaatta ctcatttaaa aattttaact tctatatggg acccgaatta   1980

gacactgctg aatcctgtac agccttactc ataaataaag tacttactga atttccacca   2040

ttcaaaaaaa aaaaaaaa                                                 2058


<210>  426
<211>  323
<212>  PRT
<213>  Homosapiens

<400>  426

Met Gly Ser Arg Val Ser Arg Glu Asp Phe Glu Trp Val Tyr Thr Asp 
1               5                   10                  15      


Gln Pro His Ala Asp Arg Arg Arg Glu Ile Leu Ala Lys Tyr Pro Glu 
            20                  25                  30          


Ile Lys Ser Leu Met Lys Pro Asp Pro Asn Leu Ile Trp Ile Ile Ile 
        35                  40                  45              


Met Met Val Leu Thr Gln Leu Gly Ala Phe Tyr Ile Val Lys Asp Leu 
    50                  55                  60                  


Asp Trp Lys Trp Val Ile Phe Gly Ala Tyr Ala Phe Gly Ser Cys Ile 
65                  70                  75                  80  


Asn His Ser Met Thr Leu Ala Ile His Glu Ile Ala His Asn Ala Ala 
                85                  90                  95      


Phe Gly Asn Cys Lys Ala Met Trp Asn Arg Trp Phe Gly Met Phe Ala 
            100                 105                 110         


Asn Leu Pro Ile Gly Ile Pro Tyr Ser Ile Ser Phe Lys Arg Tyr His 
        115                 120                 125             


Met Asp His His Arg Tyr Leu Gly Ala Asp Gly Val Asp Val Asp Ile 
    130                 135                 140                 


Pro Thr Asp Phe Glu Gly Trp Phe Phe Cys Thr Ala Phe Arg Lys Phe 
145                 150                 155                 160 


Ile Trp Val Ile Leu Gln Pro Leu Phe Tyr Ala Phe Arg Pro Leu Phe 
                165                 170                 175     


Ile Asn Pro Lys Pro Ile Thr Tyr Leu Glu Val Ile Asn Thr Val Ala 
            180                 185                 190         


Gln Val Thr Phe Asp Ile Leu Ile Tyr Tyr Phe Leu Gly Ile Lys Ser 
        195                 200                 205             


Leu Val Tyr Met Leu Ala Ala Ser Leu Leu Gly Leu Gly Leu His Pro 
    210                 215                 220                 


Ile Ser Gly His Phe Ile Ala Glu His Tyr Met Phe Leu Lys Gly His 
225                 230                 235                 240 


Glu Thr Tyr Ser Tyr Tyr Gly Pro Leu Asn Leu Leu Thr Phe Asn Val 
                245                 250                 255     


Gly Tyr His Asn Glu His His Asp Phe Pro Asn Ile Pro Gly Lys Ser 
            260                 265                 270         


Leu Pro Leu Val Arg Lys Ile Ala Ala Glu Tyr Tyr Asp Asn Leu Pro 
        275                 280                 285             


His Tyr Asn Ser Trp Ile Lys Val Leu Tyr Asp Phe Val Met Asp Asp 
    290                 295                 300                 


Thr Ile Ser Pro Tyr Ser Arg Met Lys Arg His Gln Lys Gly Glu Met 
305                 310                 315                 320 


Val Leu Glu 
            


<210>  427
<211>  1681
<212>  DNA
<213>  Homosapiens

<400>  427
cacagccggc cgacaccaca ccagccgggg agccgccgcc gccgccgcca cctctgagca     60

gccggctggg agcgagagcc gacagctagt ctgcaagcca ccgctgtcgc catggggagc    120

cgcgtctcgc gggaagactt cgagtgggtc tacaccgacc agccgcacgc cgaccggcgc    180

cgggagatcc tggcaaagta tccagagata aagtccttga tgaaacctga tcccaatttg    240

atatggatta taattatgat ggttctcacc cagttgggtg cattttacat agtaaaagac    300

ttggactgga aatgggtcat atttggggcc tatgcgtttg gcagttgcat taaccactca    360

atgactctgg ctattcatga gattgcccac aatgctgcct ttggcaactg caaagcaatg    420

tggaatcgct ggtttggaat gtttgctaat cttcctattg ggattccata ttcaatttcc    480

tttaagaggt atcacatgga tcatcatcgg taccttggag ctgatggcgt cgatgtagat    540

attcctaccg attttgaggg ctggttcttc tgtaccgctt tcagaaagtt tatatgggtt    600

attcttcagc ctctctttta tgcctttcga cctctgttca tcaaccccaa accaattacg    660

tatctggaag ttatcaatac cgtggcacag gtcacttttg acattttaat ttattacttt    720

ttgggaatta aatccttagt ctacatgttg gcagcatctt tacttggcct gggtttgcac    780

ccaatttctg gacattttat agctgagcat tacatgttct taaagggtca tgaaacttac    840

tcatattatg ggcctctgaa tttacttacc ttcaatgtgg gttatcataa tgaacatcat    900

gatttcccca acattcctgg aaaaagtctt ccactggtga ggaaaatagc agctgaatac    960

tatgacaacc tccctcacta caattcctgg ataaaagtac tgtatgattt tgtgatggat   1020

gatacaataa gtccctactc aagaatgaag aggcaccaaa aaggagagat ggtgctggag   1080

taaatatcat tagtgccaaa gggattcttc tccaaaactt tagatgataa aattagccgg   1140

gcgtggcggc acatgcctgt aatcccagct acatgggagg ctgaggtggg agaattgctt   1200

gaacccagga ggcggaggca gaggctgcag tgacccaaga ttgtgccact gcactccacc   1260

ctgggcaaca gagcaagacc ccatctcaaa aataaataaa tatatataaa aaataaaaag   1320

ctatttctag tttatttcac tataaagttt tgctttatta aaaagctaat aaacagctat   1380

taatcacagt gtattagtat ttgttacatt tttgtatttc actatcttta tactatataa   1440

tatggtaact tgggtaccgg gggaacttta aaatttcatc tcaaaaataa tttttaaaaa   1500

gcctgaggta tgatatagca taaaagattg agatgaaaat atatttccct gtaagctgaa   1560

ttactcattt aaaaatttta acttctatat gggacccgaa ttagacactg ctgaatcctg   1620

tacagcctta ctcataaata aagtacttac tgaatttcca ccattcaaaa aaaaaaaaaa   1680

a                                                                   1681


<210>  428
<211>  323
<212>  PRT
<213>  Homosapiens

<400>  428

Met Gly Ser Arg Val Ser Arg Glu Asp Phe Glu Trp Val Tyr Thr Asp 
1               5                   10                  15      


Gln Pro His Ala Asp Arg Arg Arg Glu Ile Leu Ala Lys Tyr Pro Glu 
            20                  25                  30          


Ile Lys Ser Leu Met Lys Pro Asp Pro Asn Leu Ile Trp Ile Ile Ile 
        35                  40                  45              


Met Met Val Leu Thr Gln Leu Gly Ala Phe Tyr Ile Val Lys Asp Leu 
    50                  55                  60                  


Asp Trp Lys Trp Val Ile Phe Gly Ala Tyr Ala Phe Gly Ser Cys Ile 
65                  70                  75                  80  


Asn His Ser Met Thr Leu Ala Ile His Glu Ile Ala His Asn Ala Ala 
                85                  90                  95      


Phe Gly Asn Cys Lys Ala Met Trp Asn Arg Trp Phe Gly Met Phe Ala 
            100                 105                 110         


Asn Leu Pro Ile Gly Ile Pro Tyr Ser Ile Ser Phe Lys Arg Tyr His 
        115                 120                 125             


Met Asp His His Arg Tyr Leu Gly Ala Asp Gly Val Asp Val Asp Ile 
    130                 135                 140                 


Pro Thr Asp Phe Glu Gly Trp Phe Phe Cys Thr Ala Phe Arg Lys Phe 
145                 150                 155                 160 


Ile Trp Val Ile Leu Gln Pro Leu Phe Tyr Ala Phe Arg Pro Leu Phe 
                165                 170                 175     


Ile Asn Pro Lys Pro Ile Thr Tyr Leu Glu Val Ile Asn Thr Val Ala 
            180                 185                 190         


Gln Val Thr Phe Asp Ile Leu Ile Tyr Tyr Phe Leu Gly Ile Lys Ser 
        195                 200                 205             


Leu Val Tyr Met Leu Ala Ala Ser Leu Leu Gly Leu Gly Leu His Pro 
    210                 215                 220                 


Ile Ser Gly His Phe Ile Ala Glu His Tyr Met Phe Leu Lys Gly His 
225                 230                 235                 240 


Glu Thr Tyr Ser Tyr Tyr Gly Pro Leu Asn Leu Leu Thr Phe Asn Val 
                245                 250                 255     


Gly Tyr His Asn Glu His His Asp Phe Pro Asn Ile Pro Gly Lys Ser 
            260                 265                 270         


Leu Pro Leu Val Arg Lys Ile Ala Ala Glu Tyr Tyr Asp Asn Leu Pro 
        275                 280                 285             


His Tyr Asn Ser Trp Ile Lys Val Leu Tyr Asp Phe Val Met Asp Asp 
    290                 295                 300                 


Thr Ile Ser Pro Tyr Ser Arg Met Lys Arg His Gln Lys Gly Glu Met 
305                 310                 315                 320 


Val Leu Glu 
            


<210>  429
<211>  2921
<212>  DNA
<213>  Homosapiens

<400>  429
ctaggagctg gcggtccgag ctgtggcttg aaagaccgac gcgatgaagc ccagacctgc     60

agggttcgtg gataataaac tcaagcagcg agtcatccag taccttacca gtaacaaatg    120

tggcaaatat gtggacattg gagtcttagc gtctgattta caaagagtgt acagtataga    180

ctatggtcga agaaaaagaa atgcttttag gattcaggta gaaaaagtat ttagcataat    240

tagtagtgag aaggaactta agaatttaac agaattagaa gatgaacatt tggcaaaaag    300

ggcaagacaa ggtgaagagg ataatgagta tactgaaagc tattctgatg atgattcaag    360

tatggaagac tacccagatc cacagtcagc aaatcacatg aacagttccc tgctgtcttt    420

atatcggaaa ggaaatcctg attctgtttc aaatactcct gagatggagc aaagagaaac    480

cacctcttca acaccacgga taagttccaa aacaggctcc attcccttga agacccctgc    540

caaagattct gaaggaggat ggtttattga caaaacccca agtgtaaaga aagacagttt    600

tttcttggac ctgtcatgtg agaaaagtaa tcctaagaag ccaataactg agatacagga    660

ttcaaaagat tcttctcttt tggagagtga tatgaaacgg aaaggcaagc taaagaataa    720

aggaagcaaa aggaagaaag aagatcttca ggaagtagat ggagaaattg aagctgtcct    780

gcaaaagaaa gctaaagcca gggggttaga attccagatc tccaacgtga agtttgaaga    840

tgtgggaggc aatgatatga cattaaaaga ggtctgcaag atgctcatac acatgcgtca    900

cccggaggtg taccaccacc tgggcgtcgt gccccctcgt ggagttctcc ttcatggacc    960

accaggctgt gggaagacat tacttgcaca tgcaattgct ggggaacttg acctgccaat   1020

tttgaaagtg gctgctccag agattgtgtc tggagtatcc ggagagtctg agcagaagct   1080

gagagaacta tttgagcaag ctgtgtcaaa tgcaccatgt atcattttca ttgatgaaat   1140

tgatgctatt acccccaaaa gagaagtggc ttcaaaagat atggaacgaa gaattgtagc   1200

ccaactccta acctgcatgg atgatctgaa taatgtggct gctacagccc gggtcctagt   1260

tattggagct actaatcgac cagactcgtt agaccctgct ttgagacgtg cgggaaggtt   1320

cgaccgagaa atatgcctag gtatcccaga tgaagcatcc agggaaagaa tacttcaaac   1380

attgtgcaga aaactgaggc ttcctcaagc ttttgatttc tgtcacttag cacacctaac   1440

tccaggcttt gttggtgctg atctcatggc actgtgccga gaggcagcaa tgtgtgcagt   1500

caatagagtc ttaatgaagc tacaggaaca gcagaagaaa aatcctgaaa tggaagattt   1560

gccatctaaa ggagtccagg aggaaaggct gggaactgag cccacttctg aaacacagga   1620

tgaattacaa aggctgctgg ggttgctaag agaccaagat cccctctcag aggagcagat   1680

gcaaggactg tgcattgaac tgaatgattt cattgttgct ctatcctcag tccaaccctc   1740

tgccaaaagg gaaggctttg tcactgtccc taatgtgaca tgggcagata ttggtgccct   1800

ggaagacatt agagaggagc tcaccatggc aatattggca ccagtacgca acccagacca   1860

gttcaaagct cttggattgg tgactccagc tggggtcctc cttgctggtc ctcctggctg   1920

tgggaagact ctgctggcga aggctgttgc aaatgagtcc ggactaaatt ttatatctgt   1980

caagggcccc gaattactaa acatgtatgt tggtgagagt gaacgtgctg tgcgacaagt   2040

ttttcaacga gccaagaact cagcaccctg tgtgatattc tttgatgaag tggatgcttt   2100

atgtcctcga agatcagacc gagagacagg ggcaagtgtc cgagtggtga atcagctact   2160

tacagagatg gatggtctgg aagcacgcca gcaggttttt attatggcag ccactaacag   2220

gccagatata attgaccctg caatcctgcg cccgggccgc ctggacaaaa cactgtttgt   2280

gggtttaccg ccccctgcag atcgccttgc catcttaaaa actatcacaa aaaatggtac   2340

caaaccacca ctggatgcag atgtaaattt ggaagcaatt gctggtgacc ttcgctgtga   2400

ttgctatacg ggcgcagatc tctctgcttt ggtacgagaa gcttctatct gtgccctgag   2460

acaggaaatg gcaagacaga agagtggaaa tgaaaaaggt gaactcaagg ttagtcataa   2520

gcattttgaa gaagctttca agaaagtaag atcatctata tcaaaaaagg atcaaatcat   2580

gtatgaacgt ttgcaggagt ccctcagccg gtgatgtctc cagcagccgg cttagaggag   2640

ctagcccatc aagccggcag agaatccccc acacgctctg aaggacccac tttcagctgg   2700

acacaggcgc ggcctcatgt aaacatttta ttttcaaatg aatgaggcca agctgaagct   2760

gaagctgaag attcttccca tctggccagc cttgtgtgaa aatgccttct tcctctttaa   2820

gaaaaaggac aatttttaaa ctgctgaaat aaaatgactg ttacattttt caaataaaac   2880

ttttactttg aactattttg actataaaaa aaaaaaaaaa a                       2921


<210>  430
<211>  856
<212>  PRT
<213>  Homosapiens

<400>  430

Met Lys Pro Arg Pro Ala Gly Phe Val Asp Asn Lys Leu Lys Gln Arg 
1               5                   10                  15      


Val Ile Gln Tyr Leu Thr Ser Asn Lys Cys Gly Lys Tyr Val Asp Ile 
            20                  25                  30          


Gly Val Leu Ala Ser Asp Leu Gln Arg Val Tyr Ser Ile Asp Tyr Gly 
        35                  40                  45              


Arg Arg Lys Arg Asn Ala Phe Arg Ile Gln Val Glu Lys Val Phe Ser 
    50                  55                  60                  


Ile Ile Ser Ser Glu Lys Glu Leu Lys Asn Leu Thr Glu Leu Glu Asp 
65                  70                  75                  80  


Glu His Leu Ala Lys Arg Ala Arg Gln Gly Glu Glu Asp Asn Glu Tyr 
                85                  90                  95      


Thr Glu Ser Tyr Ser Asp Asp Asp Ser Ser Met Glu Asp Tyr Pro Asp 
            100                 105                 110         


Pro Gln Ser Ala Asn His Met Asn Ser Ser Leu Leu Ser Leu Tyr Arg 
        115                 120                 125             


Lys Gly Asn Pro Asp Ser Val Ser Asn Thr Pro Glu Met Glu Gln Arg 
    130                 135                 140                 


Glu Thr Thr Ser Ser Thr Pro Arg Ile Ser Ser Lys Thr Gly Ser Ile 
145                 150                 155                 160 


Pro Leu Lys Thr Pro Ala Lys Asp Ser Glu Gly Gly Trp Phe Ile Asp 
                165                 170                 175     


Lys Thr Pro Ser Val Lys Lys Asp Ser Phe Phe Leu Asp Leu Ser Cys 
            180                 185                 190         


Glu Lys Ser Asn Pro Lys Lys Pro Ile Thr Glu Ile Gln Asp Ser Lys 
        195                 200                 205             


Asp Ser Ser Leu Leu Glu Ser Asp Met Lys Arg Lys Gly Lys Leu Lys 
    210                 215                 220                 


Asn Lys Gly Ser Lys Arg Lys Lys Glu Asp Leu Gln Glu Val Asp Gly 
225                 230                 235                 240 


Glu Ile Glu Ala Val Leu Gln Lys Lys Ala Lys Ala Arg Gly Leu Glu 
                245                 250                 255     


Phe Gln Ile Ser Asn Val Lys Phe Glu Asp Val Gly Gly Asn Asp Met 
            260                 265                 270         


Thr Leu Lys Glu Val Cys Lys Met Leu Ile His Met Arg His Pro Glu 
        275                 280                 285             


Val Tyr His His Leu Gly Val Val Pro Pro Arg Gly Val Leu Leu His 
    290                 295                 300                 


Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala His Ala Ile Ala Gly 
305                 310                 315                 320 


Glu Leu Asp Leu Pro Ile Leu Lys Val Ala Ala Pro Glu Ile Val Ser 
                325                 330                 335     


Gly Val Ser Gly Glu Ser Glu Gln Lys Leu Arg Glu Leu Phe Glu Gln 
            340                 345                 350         


Ala Val Ser Asn Ala Pro Cys Ile Ile Phe Ile Asp Glu Ile Asp Ala 
        355                 360                 365             


Ile Thr Pro Lys Arg Glu Val Ala Ser Lys Asp Met Glu Arg Arg Ile 
    370                 375                 380                 


Val Ala Gln Leu Leu Thr Cys Met Asp Asp Leu Asn Asn Val Ala Ala 
385                 390                 395                 400 


Thr Ala Arg Val Leu Val Ile Gly Ala Thr Asn Arg Pro Asp Ser Leu 
                405                 410                 415     


Asp Pro Ala Leu Arg Arg Ala Gly Arg Phe Asp Arg Glu Ile Cys Leu 
            420                 425                 430         


Gly Ile Pro Asp Glu Ala Ser Arg Glu Arg Ile Leu Gln Thr Leu Cys 
        435                 440                 445             


Arg Lys Leu Arg Leu Pro Gln Ala Phe Asp Phe Cys His Leu Ala His 
    450                 455                 460                 


Leu Thr Pro Gly Phe Val Gly Ala Asp Leu Met Ala Leu Cys Arg Glu 
465                 470                 475                 480 


Ala Ala Met Cys Ala Val Asn Arg Val Leu Met Lys Leu Gln Glu Gln 
                485                 490                 495     


Gln Lys Lys Asn Pro Glu Met Glu Asp Leu Pro Ser Lys Gly Val Gln 
            500                 505                 510         


Glu Glu Arg Leu Gly Thr Glu Pro Thr Ser Glu Thr Gln Asp Glu Leu 
        515                 520                 525             


Gln Arg Leu Leu Gly Leu Leu Arg Asp Gln Asp Pro Leu Ser Glu Glu 
    530                 535                 540                 


Gln Met Gln Gly Leu Cys Ile Glu Leu Asn Asp Phe Ile Val Ala Leu 
545                 550                 555                 560 


Ser Ser Val Gln Pro Ser Ala Lys Arg Glu Gly Phe Val Thr Val Pro 
                565                 570                 575     


Asn Val Thr Trp Ala Asp Ile Gly Ala Leu Glu Asp Ile Arg Glu Glu 
            580                 585                 590         


Leu Thr Met Ala Ile Leu Ala Pro Val Arg Asn Pro Asp Gln Phe Lys 
        595                 600                 605             


Ala Leu Gly Leu Val Thr Pro Ala Gly Val Leu Leu Ala Gly Pro Pro 
    610                 615                 620                 


Gly Cys Gly Lys Thr Leu Leu Ala Lys Ala Val Ala Asn Glu Ser Gly 
625                 630                 635                 640 


Leu Asn Phe Ile Ser Val Lys Gly Pro Glu Leu Leu Asn Met Tyr Val 
                645                 650                 655     


Gly Glu Ser Glu Arg Ala Val Arg Gln Val Phe Gln Arg Ala Lys Asn 
            660                 665                 670         


Ser Ala Pro Cys Val Ile Phe Phe Asp Glu Val Asp Ala Leu Cys Pro 
        675                 680                 685             


Arg Arg Ser Asp Arg Glu Thr Gly Ala Ser Val Arg Val Val Asn Gln 
    690                 695                 700                 


Leu Leu Thr Glu Met Asp Gly Leu Glu Ala Arg Gln Gln Val Phe Ile 
705                 710                 715                 720 


Met Ala Ala Thr Asn Arg Pro Asp Ile Ile Asp Pro Ala Ile Leu Arg 
                725                 730                 735     


Pro Gly Arg Leu Asp Lys Thr Leu Phe Val Gly Leu Pro Pro Pro Ala 
            740                 745                 750         


Asp Arg Leu Ala Ile Leu Lys Thr Ile Thr Lys Asn Gly Thr Lys Pro 
        755                 760                 765             


Pro Leu Asp Ala Asp Val Asn Leu Glu Ala Ile Ala Gly Asp Leu Arg 
    770                 775                 780                 


Cys Asp Cys Tyr Thr Gly Ala Asp Leu Ser Ala Leu Val Arg Glu Ala 
785                 790                 795                 800 


Ser Ile Cys Ala Leu Arg Gln Glu Met Ala Arg Gln Lys Ser Gly Asn 
                805                 810                 815     


Glu Lys Gly Glu Leu Lys Val Ser His Lys His Phe Glu Glu Ala Phe 
            820                 825                 830         


Lys Lys Val Arg Ser Ser Ile Ser Lys Lys Asp Gln Ile Met Tyr Glu 
        835                 840                 845             


Arg Leu Gln Glu Ser Leu Ser Arg 
    850                 855     


<210>  431
<211>  2847
<212>  DNA
<213>  Homosapiens

<400>  431
ctaggagctg gcggtccgag ctgtggcttg aaagaccgac gcgatgaagc ccagacctgc     60

agggttcgtg gataataaac tcaagcagcg agtcatccag tatagactat ggtcgaagaa    120

aaagaaatgc ttttaggatt caggtagaaa aagtatttag cataattagt agtgagaagg    180

aacttaagaa tttaacagaa ttagaagatg aacatttggc aaaaagggca agacaaggtg    240

aagaggataa tgagtatact gaaagctatt ctgatgatga ttcaagtatg gaagactacc    300

cagatccaca gtcagcaaat cacatgaaca gttccctgct gtctttatat cggaaaggaa    360

atcctgattc tgtttcaaat actcctgaga tggagcaaag agaaaccacc tcttcaacac    420

cacggataag ttccaaaaca ggctccattc ccttgaagac ccctgccaaa gattctgaag    480

gaggatggtt tattgacaaa accccaagtg taaagaaaga cagttttttc ttggacctgt    540

catgtgagaa aagtaatcct aagaagccaa taactgagat acaggattca aaagattctt    600

ctcttttgga gagtgatatg aaacggaaag gcaagctaaa gaataaagga agcaaaagga    660

agaaagaaga tcttcaggaa gtagatggag aaattgaagc tgtcctgcaa aagaaagcta    720

aagccagggg gttagaattc cagatctcca acgtgaagtt tgaagatgtg ggaggcaatg    780

atatgacatt aaaagaggtc tgcaagatgc tcatacacat gcgtcacccg gaggtgtacc    840

accacctggg cgtcgtgccc cctcgtggag ttctccttca tggaccacca ggctgtggga    900

agacattact tgcacatgca attgctgggg aacttgacct gccaattttg aaagtggctg    960

ctccagagat tgtgtctgga gtatccggag agtctgagca gaagctgaga gaactatttg   1020

agcaagctgt gtcaaatgca ccatgtatca ttttcattga tgaaattgat gctattaccc   1080

ccaaaagaga agtggcttca aaagatatgg aacgaagaat tgtagcccaa ctcctaacct   1140

gcatggatga tctgaataat gtggctgcta cagcccgggt cctagttatt ggagctacta   1200

atcgaccaga ctcgttagac cctgctttga gacgtgcggg aaggttcgac cgagaaatat   1260

gcctaggtat cccagatgaa gcatccaggg aaagaatact tcaaacattg tgcagaaaac   1320

tgaggcttcc tcaagctttt gatttctgtc acttagcaca cctaactcca ggctttgttg   1380

gtgctgatct catggcactg tgccgagagg cagcaatgtg tgcagtcaat agagtcttaa   1440

tgaagctaca ggaacagcag aagaaaaatc ctgaaatgga agatttgcca tctaaaggag   1500

tccaggagga aaggctggga actgagccca cttctgaaac acaggatgaa ttacaaaggc   1560

tgctggggtt gctaagagac caagatcccc tctcagagga gcagatgcaa ggactgtgca   1620

ttgaactgaa tgatttcatt gttgctctat cctcagtcca accctctgcc aaaagggaag   1680

gctttgtcac tgtccctaat gtgacatggg cagatattgg tgccctggaa gacattagag   1740

aggagctcac catggcaata ttggcaccag tacgcaaccc agaccagttc aaagctcttg   1800

gattggtgac tccagctggg gtcctccttg ctggtcctcc tggctgtggg aagactctgc   1860

tggcgaaggc tgttgcaaat gagtccggac taaattttat atctgtcaag ggccccgaat   1920

tactaaacat gtatgttggt gagagtgaac gtgctgtgcg acaagttttt caacgagcca   1980

agaactcagc accctgtgtg atattctttg atgaagtgga tgctttatgt cctcgaagat   2040

cagaccgaga gacaggggca agtgtccgag tggtgaatca gctacttaca gagatggatg   2100

gtctggaagc acgccagcag gtttttatta tggcagccac taacaggcca gatataattg   2160

accctgcaat cctgcgcccg ggccgcctgg acaaaacact gtttgtgggt ttaccgcccc   2220

ctgcagatcg ccttgccatc ttaaaaacta tcacaaaaaa tggtaccaaa ccaccactgg   2280

atgcagatgt aaatttggaa gcaattgctg gtgaccttcg ctgtgattgc tatacgggcg   2340

cagatctctc tgctttggta cgagaagctt ctatctgtgc cctgagacag gaaatggcaa   2400

gacagaagag tggaaatgaa aaaggtgaac tcaaggttag tcataagcat tttgaagaag   2460

ctttcaagaa agtaagatca tctatatcaa aaaaggatca aatcatgtat gaacgtttgc   2520

aggagtccct cagccggtga tgtctccagc agccggctta gaggagctag cccatcaagc   2580

cggcagagaa tcccccacac gctctgaagg acccactttc agctggacac aggcgcggcc   2640

tcatgtaaac attttatttt caaatgaatg aggccaagct gaagctgaag ctgaagattc   2700

ttcccatctg gccagccttg tgtgaaaatg ccttcttcct ctttaagaaa aaggacaatt   2760

tttaaactgc tgaaataaaa tgactgttac atttttcaaa taaaactttt actttgaact   2820

attttgacta taaaaaaaaa aaaaaaa                                       2847


<210>  432
<211>  750
<212>  PRT
<213>  Homosapiens

<400>  432

Met Glu Asp Tyr Pro Asp Pro Gln Ser Ala Asn His Met Asn Ser Ser 
1               5                   10                  15      


Leu Leu Ser Leu Tyr Arg Lys Gly Asn Pro Asp Ser Val Ser Asn Thr 
            20                  25                  30          


Pro Glu Met Glu Gln Arg Glu Thr Thr Ser Ser Thr Pro Arg Ile Ser 
        35                  40                  45              


Ser Lys Thr Gly Ser Ile Pro Leu Lys Thr Pro Ala Lys Asp Ser Glu 
    50                  55                  60                  


Gly Gly Trp Phe Ile Asp Lys Thr Pro Ser Val Lys Lys Asp Ser Phe 
65                  70                  75                  80  


Phe Leu Asp Leu Ser Cys Glu Lys Ser Asn Pro Lys Lys Pro Ile Thr 
                85                  90                  95      


Glu Ile Gln Asp Ser Lys Asp Ser Ser Leu Leu Glu Ser Asp Met Lys 
            100                 105                 110         


Arg Lys Gly Lys Leu Lys Asn Lys Gly Ser Lys Arg Lys Lys Glu Asp 
        115                 120                 125             


Leu Gln Glu Val Asp Gly Glu Ile Glu Ala Val Leu Gln Lys Lys Ala 
    130                 135                 140                 


Lys Ala Arg Gly Leu Glu Phe Gln Ile Ser Asn Val Lys Phe Glu Asp 
145                 150                 155                 160 


Val Gly Gly Asn Asp Met Thr Leu Lys Glu Val Cys Lys Met Leu Ile 
                165                 170                 175     


His Met Arg His Pro Glu Val Tyr His His Leu Gly Val Val Pro Pro 
            180                 185                 190         


Arg Gly Val Leu Leu His Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu 
        195                 200                 205             


Ala His Ala Ile Ala Gly Glu Leu Asp Leu Pro Ile Leu Lys Val Ala 
    210                 215                 220                 


Ala Pro Glu Ile Val Ser Gly Val Ser Gly Glu Ser Glu Gln Lys Leu 
225                 230                 235                 240 


Arg Glu Leu Phe Glu Gln Ala Val Ser Asn Ala Pro Cys Ile Ile Phe 
                245                 250                 255     


Ile Asp Glu Ile Asp Ala Ile Thr Pro Lys Arg Glu Val Ala Ser Lys 
            260                 265                 270         


Asp Met Glu Arg Arg Ile Val Ala Gln Leu Leu Thr Cys Met Asp Asp 
        275                 280                 285             


Leu Asn Asn Val Ala Ala Thr Ala Arg Val Leu Val Ile Gly Ala Thr 
    290                 295                 300                 


Asn Arg Pro Asp Ser Leu Asp Pro Ala Leu Arg Arg Ala Gly Arg Phe 
305                 310                 315                 320 


Asp Arg Glu Ile Cys Leu Gly Ile Pro Asp Glu Ala Ser Arg Glu Arg 
                325                 330                 335     


Ile Leu Gln Thr Leu Cys Arg Lys Leu Arg Leu Pro Gln Ala Phe Asp 
            340                 345                 350         


Phe Cys His Leu Ala His Leu Thr Pro Gly Phe Val Gly Ala Asp Leu 
        355                 360                 365             


Met Ala Leu Cys Arg Glu Ala Ala Met Cys Ala Val Asn Arg Val Leu 
    370                 375                 380                 


Met Lys Leu Gln Glu Gln Gln Lys Lys Asn Pro Glu Met Glu Asp Leu 
385                 390                 395                 400 


Pro Ser Lys Gly Val Gln Glu Glu Arg Leu Gly Thr Glu Pro Thr Ser 
                405                 410                 415     


Glu Thr Gln Asp Glu Leu Gln Arg Leu Leu Gly Leu Leu Arg Asp Gln 
            420                 425                 430         


Asp Pro Leu Ser Glu Glu Gln Met Gln Gly Leu Cys Ile Glu Leu Asn 
        435                 440                 445             


Asp Phe Ile Val Ala Leu Ser Ser Val Gln Pro Ser Ala Lys Arg Glu 
    450                 455                 460                 


Gly Phe Val Thr Val Pro Asn Val Thr Trp Ala Asp Ile Gly Ala Leu 
465                 470                 475                 480 


Glu Asp Ile Arg Glu Glu Leu Thr Met Ala Ile Leu Ala Pro Val Arg 
                485                 490                 495     


Asn Pro Asp Gln Phe Lys Ala Leu Gly Leu Val Thr Pro Ala Gly Val 
            500                 505                 510         


Leu Leu Ala Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala Lys Ala 
        515                 520                 525             


Val Ala Asn Glu Ser Gly Leu Asn Phe Ile Ser Val Lys Gly Pro Glu 
    530                 535                 540                 


Leu Leu Asn Met Tyr Val Gly Glu Ser Glu Arg Ala Val Arg Gln Val 
545                 550                 555                 560 


Phe Gln Arg Ala Lys Asn Ser Ala Pro Cys Val Ile Phe Phe Asp Glu 
                565                 570                 575     


Val Asp Ala Leu Cys Pro Arg Arg Ser Asp Arg Glu Thr Gly Ala Ser 
            580                 585                 590         


Val Arg Val Val Asn Gln Leu Leu Thr Glu Met Asp Gly Leu Glu Ala 
        595                 600                 605             


Arg Gln Gln Val Phe Ile Met Ala Ala Thr Asn Arg Pro Asp Ile Ile 
    610                 615                 620                 


Asp Pro Ala Ile Leu Arg Pro Gly Arg Leu Asp Lys Thr Leu Phe Val 
625                 630                 635                 640 


Gly Leu Pro Pro Pro Ala Asp Arg Leu Ala Ile Leu Lys Thr Ile Thr 
                645                 650                 655     


Lys Asn Gly Thr Lys Pro Pro Leu Asp Ala Asp Val Asn Leu Glu Ala 
            660                 665                 670         


Ile Ala Gly Asp Leu Arg Cys Asp Cys Tyr Thr Gly Ala Asp Leu Ser 
        675                 680                 685             


Ala Leu Val Arg Glu Ala Ser Ile Cys Ala Leu Arg Gln Glu Met Ala 
    690                 695                 700                 


Arg Gln Lys Ser Gly Asn Glu Lys Gly Glu Leu Lys Val Ser His Lys 
705                 710                 715                 720 


His Phe Glu Glu Ala Phe Lys Lys Val Arg Ser Ser Ile Ser Lys Lys 
                725                 730                 735     


Asp Gln Ile Met Tyr Glu Arg Leu Gln Glu Ser Leu Ser Arg 
            740                 745                 750 


<210>  433
<211>  652
<212>  DNA
<213>  Homosapiens

<400>  433
ggacggaagg agcggcggcg acggaggagg aggatggagg cggtggtgtt cgtcttctct     60

ctcctcgatt gttgcgcgct catcttcctc tcggtctact tcataattac attgtctgat    120

ttagaatgtg attacattaa tgctagatca tgttgctcaa aattaaacaa gtgggtaatt    180

ccagaattga ttggccatac cattgtcact gtattactgc tcatgtcatt gcactggttc    240

atcttccttc tcaacttacc tgttgccact tggaatatat atcgatacat tatggtgccg    300

agtggtaaca tgggagtgtt tgatccaaca gaaatacaca atcgagggca gctgaagtca    360

cacatgaaag aagccatgat caagcttggt ttccacttgc tctgcttctt catgtatctt    420

tatagtatga tcttagcttt gataaatgac tgaagctgga gaagccgtgg ttgaagtcag    480

cctacactac agtgcacagt tgaggagcca gagacttctt aaatcatcct tagaaccgtg    540

accatagcag tatatatttt cctcttggaa caaaaaacta tttttgctgt atttttacca    600

tataaagtat ttaaaaaaca ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa            652


<210>  434
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  434

Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu 
1               5                   10                  15      


Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys 
            20                  25                  30          


Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val 
        35                  40                  45              


Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met 
    50                  55                  60                  


Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp 
65                  70                  75                  80  


Asn Ile Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Met Gly Val Phe 
                85                  90                  95      


Asp Pro Thr Glu Ile His Asn Arg Gly Gln Leu Lys Ser His Met Lys 
            100                 105                 110         


Glu Ala Met Ile Lys Leu Gly Phe His Leu Leu Cys Phe Phe Met Tyr 
        115                 120                 125             


Leu Tyr Ser Met Ile Leu Ala Leu Ile Asn Asp 
    130                 135                 


<210>  435
<211>  6250
<212>  DNA
<213>  Homosapiens

<400>  435
cgcctgcttg tcggcccaga acggggagtc gtccccctcg tcgtcgtcgt ccgcggggga     60

cctggcccac gccaatgggc tcctgccttc cgccccctcc gccgccagca acaatagcaa    120

cagcctgaat gtcaataacg gggttcccgg cggggcggcc gccgcatcct cagccaccgt    180

cgcagctgcc tccgccacca ccgccgcctc ctcttccttg gccaccccag aactgggcag    240

cagcctcaag aagaagaagc ggctctccca gtcagatgag gatgtcatta ggctaatagg    300

acagcacttg aatggcttag ggctcaacca gactgttgat ctcctcatgc aagagtcagg    360

atgtcgttta gaacatcctt ctgctaccaa attccgaaat catgtcatgg aaggagactg    420

ggataaggca gaaaatgacc tgaatgaact aaagccttta gtgcattctc ctcatgctat    480

tgtggtaaga ggcgcacttg aaatctctca aacgttgttg ggaataattg tgaggatgaa    540

gtttttgctg ctgcagcaga agtacctaga atacctggag gatggcaagg tcctggaggc    600

acttcaagtt ctacgctgtg aattgacgcc gctgaaatac aatacagagc gcattcatgt    660

tcttagtggg tatctgatgt gtagccatgc agaagaccta cgtgcaaaag cagaatggga    720

aggcaaaggg acagcttccc gatctaaact attggataaa cttcagacct atttaccacc    780

atcagtgatg cttcccccac ggcgtttaca gactctcctg cggcaggcgg tggaactaca    840

aagggatcgg tgcctatatc acaataccaa acttgataat aatctagatt ctgtgtctct    900

gcttatagac catgtttgta gtaggaggca gttcccatgt tatacgcagc agatacttac    960

ggagcattgt aatgaagtgt ggttctgtaa attctctaat gatggcacta aactagcaac   1020

aggatcaaaa gatacaacag ttatcatatg gcaagttgat ccggatacac acctgctaaa   1080

actgcttaaa acattagaag gacatgctta tggcgtttct tatattgcat ggagtccaga   1140

tgacaactat cttgttgctt gtggcccaga tgactgctct gagctttggc tttggaatgt   1200

acaaacagga gaactaagga caaaaatgag ccagtctcat gaagacagtt tgacaagtgt   1260

ggcttggaat ccagatggga agcgctttgt gactggaggt cagcgtgggc agttctatca   1320

gtgtgactta gatggtaatc tccttgactc ctgggaaggg gtaagagtgc aatgcctttg   1380

gtgcttgagt gatggaaaga ctgttctggc atcagataca caccagcgaa ttcggggcta   1440

taacttcgag gaccttacag ataggaacat agtacaagaa gatcatccta ttatgtcttt   1500

tactatttca aaaaatggcc gattagcttt gttaaatgta gcaactcagg gagttcattt   1560

atgggacttg caagacagag ttttagtaag aaagtatcaa ggtgttacac aagggtttta   1620

tacaattcat tcatgttttg gaggccataa tgaagacttc atcgctagtg gcagtgaaga   1680

tcacaaggtt tacatctggc acaaacgtag tgaactgcca attgcggagc tgacagggca   1740

cacacgtaca gtaaactgtg tgagctggaa cccacagatt ccatccatga tggccagcgc   1800

ctcagatgat ggcactgtta gaatatgggg accagcacct tttatagacc accagaatat   1860

tgaagaggaa tgcagtagca tggatagttg atggtgaatt tggagcagac gacttctgtt   1920

taacttaaaa ttagtcgtat tttaatggct tgggatttgg tgcaaacaaa catgattgat   1980

agctggacag acatgctcgt catgaaaaaa gaaccatttc tgaagcccga ttggggccaa   2040

acatttacac cttgcttcat agtaaccagt tgagatgaag cacgtcgtta gaacgttgtt   2100

ggacaccatg ttgaattatt cccccatcgg ttgtgaagaa ctgtgctaca ttcaggctta   2160

cccattgaac tcagtatata tatttttttc cttcctgtct tttgtctggc aggataccat   2220

tcttgttgct cttctgtgta atgaagttta aatgcttgtt tggaaaactt tatttaacag   2280

tttagaaggc ttgatagaaa gagtgcatta gtctgaagag tatacattgg ataggaaaga   2340

atttccttct tttgtttctc caaatctttc cgccttattt agcttgagat ctttgcagct   2400

tggttcatgg attctagcct tgcccgttgc gcagtatata ctgatccaga tgataaacca   2460

gtgaactatg tcaaaagcac tctcaatatt acatttgaca aaaagttttg tacttttcac   2520

atagcttgtt gccccgtaaa agggttaaca gcacaatttt ttaaaaataa attaagaagt   2580

atttatagga ttaaagtgac ttcatttgta tacatttgga atctaaacca gcttaaaaac   2640

agtttcctca atgacttaga tacacagtat aactgatgct cttctggaat accacatgag   2700

acatggtcag aaacagtgct tggaaggaca ttacacaaga aattcagagt aatgctttga   2760

agatttcccc ccttttgttt tattcctgaa ggaacatcag tacccgatct tgaagaaatt   2820

caagattcaa aaagaatttt aaatacacca acatgagaca tcagtagtca gttggttttc   2880

agtaaagctt gttccaagtt gttctcaact taggaagtaa ttttggtgtg atctagcaaa   2940

agagtaggaa tcagcgatac aaccactttg gaagtttata gtataattga aattattaga   3000

agaattcagc aggttacaga catacttaaa ctgggattaa aacctcatag tcatttttct   3060

taattgccct taatattttg acatataggg atacataaat ttaaagaata ttttttctca   3120

gttttttcag atattgccat actgaacctc attctaaact ggtgctgtgg atagtctttc   3180

cctctcccct cctgttttag tttaaggaaa ggtttccttc atggaaaagc acttttaatt   3240

ttgagaattt cacatttaaa ataagccaaa agcctgatgt tcacattgtg cttttaaact   3300

ccgtaacagc tgaatacaac ataacatagt ctcccttgaa attccctccc tttttcagta   3360

gaggataaat agggtgactc cagctgttgg aatgagaatg gggatacccc caaaataaga   3420

ttctggtgaa gaaaaagtct tgtactaagt tcccctttag gtgtagccaa gtctataata   3480

taattatgat catgaataga ctccagaatc cacaaagaga agagggcttg gatgtcaaaa   3540

attcttccat tgtggggtag gtggtcgggg atgggagaaa gggaaaagtc agggaagggg   3600

agaagaaaga aaaacacatt tggccttaaa atagcatgca ttctcccaga agcccatagt   3660

aaagaaaatg acagatcgtg gtcagcagac tcttatcaaa ttggtatgta aaagatttct   3720

tcaagctcca ttttgcagag accaccactt agagaatcaa aaaattcctg ttttgatact   3780

tctaagttaa aatatatgtt acagtttatc tggtacttca tttttcttaa ctaaaattac   3840

tttttacttt aagcttgaat aaaaatcttc attggtaact gtatgtaatt aagtggcaac   3900

ttctctttac ctcagtatag ttaaaaacca ttcatatttt aagtgattca tgtataccct   3960

gaagccgtta atacacccca gtctctatgg taacatcact aaatgtgggc atagaaactc   4020

cacagctgtt tacaaatttg gttacagtgt gctacggtgc atttgtaaca ctcagatttg   4080

tgcccattca ggggcaattt ggcactcaga ttctactcta cttcacctaa ccacccctag   4140

atctgagttt tcagagtgct tctgaagtac agtttaaaaa cactttttaa aaagtggagt   4200

aaaagtgagg cacattttac aagaacataa ctcctattaa aacggagtaa caactatgca   4260

aaggtttcta tagcagctag gtgagtttgt tttccgggtc tgtcttaact ggcagcttcc   4320

tgtacatact ggtacttatt tgctgtaaac gtctgtttca tacatttgcc atgcagtgac   4380

tgtgctcgaa aggtgaaatc aatggtaaag aagcctagga ttttatggta tgagaaactg   4440

atcgcaggat tttctgatcc atagctatta attgaaaact tctgatagtg ctgtaggctc   4500

tatagtaggc ttaagagtga gtcttatact atgaagccag ccacaagata ctaacaaatg   4560

tataaattga aaagtaccaa tactttttgc acatagatca aaatagagtg gagaatttgg   4620

gctccaaaaa tcaggttagt aggctcattt ccatgtgctt aaaaatgttt ttgttgttat   4680

gcattgatta agggctagag caaatataaa attaaatgtc tttttcctcc aaataattgg   4740

ttattaatgg taaaatgttg gacttgggga ttactgagat tagtatgtgg gtagtaaaga   4800

attggagtgg gagttagtgg ggagggatga caaagcttca gctttggttt ttgtattttt   4860

ttagtcttca taacagctac atttctgttg ctcttattgg ccagataaat gtgttatatt   4920

aaaccaggta agtattttaa acagagaaca ttttatttgc atatatccct acaaattggc   4980

ccattttatt gggtgggggg ataaaaaagg gattccctaa ctttaaataa tcagaatatc   5040

ctgcaattga aaggagaaaa aaatccaatt ttgtcagtat tttcttagtc tgaaaaaaac   5100

agcagtagta atctggtgaa tgttattatt aggagtgttc tgcctctaca gtggcatatt   5160

ccatgacatt aatagaaaac ccttctttcc cacccctccc catcttgaca ttttcttttt   5220

taggatgttg gttcctgcaa acaagaactg accctatcac ctctgcctca cagtgggtaa   5280

atatatcata catctcttga aagggaaaat atccatgtca gtttctttca cagtagaaga   5340

atggctgctt ttgaatgggg aggaaagaag acatttttct taatatcctt tttgtcccat   5400

ctctaaaatg tataaatatt ttgatttggt tttactttaa tttctcattc ataatttcgc   5460

aactgtcctt ttgggttgcc ctccaacaca ttacttccat ttcagaaacc atatctgatt   5520

taatataaac tgctaactta agaagaggtg aatttgcatt tacacttaga cactttctaa   5580

aaacagggtg aacttaattg aaatttttca gtgttgttaa gctattgtta tagtagctgc   5640

cctatagtta caaaaataaa aactataaaa acccatcccc tatctactta atccagatag   5700

cctggattta acaaaaccaa tagtataaaa atgtgtgtgt gtgttctgtg tgtgtgtgag   5760

agagagagta cttgattcat taaaaagtcc tggaaacagc tgttctagga tcttgtcatt   5820

tttactgaaa gtctcgtgca catgtgaagt gccctctgag tttaaggttt ggttaatact   5880

ggtatatttt tataagattg aaattgtgtc cccatcttta acttaaacat tttcattatc   5940

agggtcaatg tgctagaact gaattgtaac atttttaggc acagatggaa aaaaatgtta   6000

ttggctcctt gaaaatgtgt gtgtgtggcg aggggaatag atccacaaaa gcatgtatgt   6060

acttacaaac caagctgtag agatcaagaa aagaacttaa gtgttgatct caagatttct   6120

aaattgtcaa gatttacatg gcattgtggt ggaactagtt aacacttaga gcttttggta   6180

tgtaataact atttgctatg gactgattaa atgtttcaaa agattgtgtt cttcaaaaaa   6240

aaaaaaaaaa                                                          6250


<210>  436
<211>  514
<212>  PRT
<213>  Homosapiens

<400>  436

Met Gln Glu Ser Gly Cys Arg Leu Glu His Pro Ser Ala Thr Lys Phe 
1               5                   10                  15      


Arg Asn His Val Met Glu Gly Asp Trp Asp Lys Ala Glu Asn Asp Leu 
            20                  25                  30          


Asn Glu Leu Lys Pro Leu Val His Ser Pro His Ala Ile Val Val Arg 
        35                  40                  45              


Gly Ala Leu Glu Ile Ser Gln Thr Leu Leu Gly Ile Ile Val Arg Met 
    50                  55                  60                  


Lys Phe Leu Leu Leu Gln Gln Lys Tyr Leu Glu Tyr Leu Glu Asp Gly 
65                  70                  75                  80  


Lys Val Leu Glu Ala Leu Gln Val Leu Arg Cys Glu Leu Thr Pro Leu 
                85                  90                  95      


Lys Tyr Asn Thr Glu Arg Ile His Val Leu Ser Gly Tyr Leu Met Cys 
            100                 105                 110         


Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu Gly Lys Gly 
        115                 120                 125             


Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr Tyr Leu Pro 
    130                 135                 140                 


Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu Leu Arg Gln 
145                 150                 155                 160 


Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn Thr Lys Leu 
                165                 170                 175     


Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His Val Cys Ser 
            180                 185                 190         


Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr Glu His Cys 
        195                 200                 205             


Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr Lys Leu Ala 
    210                 215                 220                 


Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val Asp Pro Asp 
225                 230                 235                 240 


Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His Ala Tyr Gly 
                245                 250                 255     


Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu Val Ala Cys 
            260                 265                 270         


Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val Gln Thr Gly 
        275                 280                 285             


Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser Leu Thr Ser 
    290                 295                 300                 


Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly Gly Gln Arg 
305                 310                 315                 320 


Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu Asp Ser Trp 
                325                 330                 335     


Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp Gly Lys Thr 
            340                 345                 350         


Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr Asn Phe Glu 
        355                 360                 365             


Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro Ile Met Ser 
    370                 375                 380                 


Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn Val Ala Thr 
385                 390                 395                 400 


Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu Val Arg Lys 
                405                 410                 415     


Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser Cys Phe Gly 
            420                 425                 430         


Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp His Lys Val 
        435                 440                 445             


Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu Leu Thr Gly 
    450                 455                 460                 


His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln Ile Pro Ser 
465                 470                 475                 480 


Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile Trp Gly Pro 
                485                 490                 495     


Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys Ser Ser Met 
            500                 505                 510         


Asp Ser 
        


<210>  437
<211>  3259
<212>  DNA
<213>  Homosapiens

<400>  437
ggccgtcggg tgtgagctgc gccgaccgct ctgagggttc gtggcccacc gctccttcgc     60

ggtccctgcc gccaccgtcc acgctcagcg ttgtagagaa gatggtgggt cggaacagcg    120

ccatcgccgc cggtgtatgc ggggcccttt tcattgggta ctgcatctac ttcgaccgca    180

aaagacgaag tgaccccaac ttcaagaaca ggcttcgaga acgaagaaag aaacagaagc    240

ttgccaagga gagagctggg ctttccaagt tacctgacct taaagatgct gaagctgttc    300

agaagttctt ccttgaagaa atacagcttg gtgaagagtt actagctcaa ggtgaatatg    360

agaagggcgt agaccatctg acaaatgcaa ttgctgtgtg tggacagcca cagcagttac    420

tgcaggtctt acagcaaact cttccaccac cagtgttcca gatgcttctg actaagctcc    480

caacaattag tcagagaatt gtaagtgctc agagcttggc tgaagatgat gtggaatgag    540

aaacaaatgt caacataata aaatctcagt taaaaatatt ttaaaaattc ttggtagttg    600

agcagctctg ggggaataag ggcaaatatg cttgttatga actacactga aatctaccaa    660

agttaatgtt tactttgtgt agatccattt gtctatttta tttatttttc ccagtgaaaa    720

gtgtattttg atagagaact tttcattcta taaatacact atgagttact aaaatatcat    780

ggattttgtt tattcctgaa acatagttac atagttaaac tgtacatatg acatggctta    840

tgttaaaaat acccagtgct cagttttgaa agataggcaa aaaaaaaaaa agtataggag    900

aaactgaaga atgtacactt ttttagaggg cacattttgc tgtaaatctg gaaatttgat    960

agacttgact gtgtttgtga aaactgagca ttaaaggttt tgattgatcc tttctttcca   1020

tttaatctct gagacgtaaa tatgtgaggt gtgctgctgt gctgggttaa cagcttcctt   1080

ccctttctgt gtagcagtct tgaaatgttc tgtttaaatc agtaggctta atgtgttctg   1140

ggtatttatc tccttgtatt ttaaatatat gtagttgcaa atagcaccag gaattagatt   1200

tctgtacacc cctaatctag ccttgtgagc ttcgctagtt aatgtgtgct cactttccct   1260

ccatttgtta cgtgagagaa tgcgtctgct gatcactgaa gtgtcccttt tagcttctga   1320

ttcattgggt tctgttgggc atctttaaat ccaccttaac ctgaggaatg tatgtgggca   1380

accaggccct gcattttttt atattctgaa ttttgcatgc ttgcctgact tagtatttct   1440

gaattgatgt tttttttaat ggtataacta tcttgatttt cactgaaatt atatggttct   1500

gtcactactc tgtaaattaa tccgaaactt ttaaggtaac tgggatgatc tgcttgtaaa   1560

aatgcttgtt gccttttgct ttatcttcag tgtacctcct taatcctgct tcaacttgat   1620

tatcttgtga aacgatgaga gtaagttgca accttgtgac tgaaaacttg aaaagagtgg   1680

agcaggtggg acctcttatt ctcaaatagt gacatattct ccgtagtcac agtttcagaa   1740

ctgagtaagg atccttggta cttggtggca tctgttgaac tgaggagcat ttctcattgt   1800

aaagattgcc tttgttctgt ctaaaagtct ggagaaatcc caaagacttt tcctatgtac   1860

taggcatttt attttgattg acttacaaac tcttcttaat cattatcaat ctcggttttt   1920

ttgtggtgca gtggaaggag aaataggtct agtttctgcc tctgattagc cgcacagcct   1980

tgaacaaatc acatttcatc tttgaactta cctctactgt tagactaggc gactcacatt   2040

tgaggacttt tctcgggtat cttgagggtt tgtgatcctg aacccttaaa cagtgctttt   2100

ttgttacaca ggagggcttt tttgggggga tgaccagtac agacatgcca gttagtttta   2160

ctagtgggat cccaaatcca aagcagtgta gtggtgattg gtcagtgact aaccaggcag   2220

ctaagaagtc ttaggcagca gcccagacat gtatagaggg gcagttagag ggagaacagg   2280

ggtgggaaag ggagcaaggg gcagatagct cagcaaggaa agaatgggct cagaaaaagg   2340

agggctggct ggaggagtga ggggcagctt aagtttgggg agggtagaaa cgccgtttcc   2400

ttgggaactg gagtgcagta tgagctgggt gtcacttggc tctgaacata ctggctttgc   2460

tgtaatgctt gaaaaggcgt tggtatcttc attttacagt tcattaaccc aagtacgttt   2520

tcttatttaa atgacaactt tggtgcttta aaatgaggta ccacttttta aagctagctg   2580

tgtcgagtta aagaaaaaat cagcagtttt ttctcccaga aatgtaattg ccaaacactt   2640

ttcatcccca tcttaagttt tacaaggtga tgtaatcagc ttgttgtagt gatgctggcc   2700

aaatggtgct cagcaggtga gaacaaaaaa accccagatt tcagtgaact aatacacagc   2760

ttgagcgttt ccatgtgcta atgttgcaca cttactaaaa aactttggaa atggaaaata   2820

atgtattagt gcaacagttg atgtgcttct ttgggcaaag atatagtttt gttccacaat   2880

ttgtacttaa aagcgaaaga acattgaaaa catagactta ctggctgtag caatgctggc   2940

ctgttaactg ataactagaa cttaggttca cgtttatgta aagtgtgtaa aacctagtag   3000

agcttgcata gtcggcactc agtaaatgtt tggttccttt tgccccttgg taagtttatt   3060

ttaccatcct cccacctgcc attctgactt tattaaatca acatgtggac cagagtgtta   3120

atgagatgtt attgcagaag agattgagaa aattggtata tcatgcagat aacatacaaa   3180

atctttttgt aacgtaaaaa atgcagtttt attattgctt gtgcctcaac tgtttaagtg   3240

aatattaaag ggcttggag                                                3259


<210>  438
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  438

Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala Leu 
1               5                   10                  15      


Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Lys Arg Arg Ser Asp Pro 
            20                  25                  30          


Asn Phe Lys Asn Arg Leu Arg Glu Arg Arg Lys Lys Gln Lys Leu Ala 
        35                  40                  45              


Lys Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu 
    50                  55                  60                  


Ala Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Leu Ala Gln Gly Glu Tyr Glu Lys Gly Val Asp His Leu Thr Asn Ala 
                85                  90                  95      


Ile Ala Val Cys Gly Gln Pro Gln Gln Leu Leu Gln Val Leu Gln Gln 
            100                 105                 110         


Thr Leu Pro Pro Pro Val Phe Gln Met Leu Leu Thr Lys Leu Pro Thr 
        115                 120                 125             


Ile Ser Gln Arg Ile Val Ser Ala Gln Ser Leu Ala Glu Asp Asp Val 
    130                 135                 140                 


Glu 
145 


<210>  439
<211>  6065
<212>  DNA
<213>  Homosapiens

<400>  439
agcgatgttt gcccgtcagt cgagtccgga gtgaggagct cggtcgccga agcggaggga     60

gactcttgag cttcatcttg ccgccgccac ggccaccgcc tggacctttg cccggaggga    120

gctgcagagg gtccatcgcc gccgtcctct ggagggcagc gcgattgggg gcccggacct    180

ccagtccggg ggggattttt cgtcgtcccc ctccccccaa ccagggagcc cgagcggccg    240

ccaaacaaag gtaccagtcg ccgccgcggg aggaggagga gccggagcct ctgcctcagc    300

agccgctgga cccgccgccc ttcttcccca tctctccccc gggcctgctg gttttggggg    360

ggagaaggag agaggggact ctggacgtgc cagggtcaga tctcgcctcc gaggaaggtg    420

cagctgaacc tggtgtttta gaggatacct tggtcccaga gtcatcatga aggcccttga    480

tgagcctccc tatttgacag tgggcactga tgtgagtgct aaatacagag gagccttttg    540

tgaagccaag atcaagacag caaaaagact tgtcaaagtc aaggtgacat ttagacatga    600

ttcttcaaca gtggaagttc aggatgacca cataaagggc ccactaaagg taggagctat    660

tgtggaagtg aagaatcttg atggtgcata tcaggaagct gttatcaata aactaacaga    720

tgcgagttgg tacactgtag tttttgatga cggagatgag aagacactga gacgatcttc    780

actgtgcctg aaaggagaga ggcattttgc tgaaagtgaa acattagacc agctcccact    840

caccaaccct gagcattttg gcactccagt cataggaaag aaaacaaata gaggaagaag    900

atctaatcat ataccagagg aagagtcttc atcatcctcc agtgatgaag atgaggatga    960

taggaaacag attgatgagc tactaggcaa agttgtatgt gtagattaca ttagtttgga   1020

taaaaagaaa gcactgtggt ttcctgcatt ggtggtttgt cctgattgta gtgatgagat   1080

tgctgtaaaa aaggacaata ttcttgttcg atctttcaaa gatggaaaat ttacttcagt   1140

tccaagaaaa gatgtccatg aaattactag tgacactgca ccaaagcctg atgctgtttt   1200

aaagcaagcc tttgaacagg cacttgaatt tcacaaaagt agaactattc ctgctaactg   1260

gaagactgaa ttgaaagaag atagctctag cagtgaagca gaggaagaag aggaggagga   1320

agatgatgaa aaagaaaagg aggataatag cagtgaagaa gaagaagaaa tagaaccatt   1380

tccagaagaa agggagaact ttcttcagca attgtacaaa tttatggaag atagaggtac   1440

acctattaac aaacgacctg tacttggata tcgaaatttg aatctcttta agttattcag   1500

acttgtacac aaacttggag gatttgataa tattgaaagt ggagctgttt ggaaacaagt   1560

ctaccaagat cttggaatcc ctgtcttaaa ttcagctgca ggatacaatg ttaaatgtgc   1620

ttataaaaaa tacttatatg gttttgagga gtactgtaga tcagccaaca ttgaatttca   1680

gatggcattg ccagagaaag ttgttaacaa gcaatgtaag gagtgtgaaa atgtaaaaga   1740

aataaaagtt aaggaggaaa atgaaacaga gatcaaagaa ataaagatgg aggaggagag   1800

gaatataata ccaagagaag aaaagcctat tgaggatgaa attgaaagaa aagaaaatat   1860

taagccctct ctgggaagta aaaagaattt attagaatct atacctacac attctgatca   1920

ggaaaaagaa gttaacatta aaaaaccaga agacaatgaa aatctggatg acaaagatga   1980

tgacacaact agggtagatg aatccctcaa cataaaggta gaagctgagg aagaaaaagc   2040

aaaatctgga gatgaaacga ataaagaaga agatgaagat gatgaagaag cagaagagga   2100

ggaggaggag gaagaagaag aagaggatga agatgatgat gacaacaatg aggaagagga   2160

gtttgagtgc tatccaccag gcatgaaagt ccaagtgcgg tatggacgag ggaaaaatca   2220

aaaaatgtat gaagctagta ttaaagattc tgatgtcgaa ggtggagagg tcctttactt   2280

ggtgcattac tgcggatgga atgtgagata cgatgaatgg attaaagcag ataaaatagt   2340

aagacctgct gataaaaatg tgccaaagat aaaacatcgg aagaaaataa agaataaatt   2400

agacaaagaa aaagacaaag atgaaaaata ctctccaaaa aactgtaaac ttcggcgctt   2460

gtccaaacca ccatttcaga caaatccatc tcctgaaatg gtatccaaac tggatctcac   2520

tgatgccaaa aactctgata ctgctcatat taagtccata gaaattactt cgatccttaa   2580

tggacttcaa gcttctgaaa gttctgctga agacagtgag caggaagatg agagaggtgc   2640

tcaagacatg gataataatg gcaaagagga atctaagatt gatcatttga ccaacaacag   2700

aaatgatctt atttcaaagg aggaacagaa cagttcatct ttgctagaag aaaacaaagt   2760

tcatgcagat ttggtaatat ccaaaccagt gtcaaaatct ccagaaagat taaggaaaga   2820

tatagaagta ttatccgaag atactgatta tgaagaagat gaagtcacaa aaaagagaaa   2880

ggatgtcaag aaggacacaa cagataaatc ttcaaaacca caaataaaac gtggtaaaag   2940

aaggtattgc aatacagaag agtgtctaaa aactggatca cctggcaaaa aggaagagaa   3000

ggccaagaac aaagaatcac tttgcatgga aaacagtagc aacagctctt cagatgaaga   3060

tgaagaagaa acaaaagcaa agatgacacc aactaagaaa tacaatggtt tggaggaaaa   3120

aagaaaatct ctacggacaa ctggtttcta ttcaggattt tcagaagtgg cagaaaaaag   3180

gattaaactt ttaaataact ctgatgaaag acttcaaaac agcagggcca aagatcgaaa   3240

agatgtctgg tcaagtattc agggacagtg gcctaaaaaa acgctgaaag agcttttttc   3300

agactctgat actgaggctg cagcttcccc accgcatcct gccccagagg agggggtggc   3360

agaggagtca ctgcagactg tggctgaaga ggagagttgt tcacccagtg tagaactaga   3420

aaaaccacct ccagtcaatg tcgatagtaa acccattgaa gaaaaaacag tagaggtcaa   3480

tgacagaaaa gcagaatttc caagtagtgg cagtaattca gtgctaaata cccctcctac   3540

tacacctgaa tcgccttcat cagtcactgt aacagaaggc agccggcagc agtcttctgt   3600

aacagtatca gaaccactgg ctccaaacca agaagaggtt cgaagtatca agagtgaaac   3660

tgatagcaca attgaggtgg atagtgttgc tggggagctc caagacctcc agtctgaagg   3720

gaatagctcg ccagcaggtt ttgatgccag tgtgagctca agcagtagta atcagccaga   3780

accagaacat cctgaaaaag cctgtacagg tcagaaaaga gtgaaagatg ctcagggagg   3840

aggaagttca tcaaaaaagc agaaaagaag ccataaagca acagtggtaa acaacaaaaa   3900

gaagggaaaa ggcacaaata gtagtgatag tgaagaactt tcagctggtg aaagtataac   3960

taagagtcag ccagtcaaat cagtttccac tggaatgaag tctcatagta ccaaatctcc   4020

cgcaaggacg cagtctccag gaaaatgtgg aaagaatggt gataaggatc ctgatctcaa   4080

ggaacccagt aatcgattac ccaaagttta caaatggagt tttcagatgt cggacctgga   4140

aaatatgaca agtgccgaac gcatcacaat tcttcaagaa aaacttcaag aaatcagaaa   4200

acattatctg tcattaaaat ctgaagtagc ttccattgat cggaggagaa agcgtttaaa   4260

gaagaaagag agagaaagtg ctgctacatc ctcatcctcc tcttcacctt catccagttc   4320

cataacagct gctgttatgt taactttagc tgaaccgtca atgtccagcg catcacaaaa   4380

tggaatgtca gttgagtgca ggtgacagca ggacttgcta aagcactttg cacttaatgg   4440

ctgttgaggg ccactttttt tttatactgc acagtggcac aaaaaaatat cagacaagca   4500

ctattttata tttaaaaatt gtttcttgac aagctgactt ggcacttaag tgcacttttt   4560

tatgaagaaa aagtacaatg aactgctttt cctcaagcaa taattgtttc caacttgtct   4620

gggaattgtg tgtctggtaa ctggaaggcc ttccactgtg gcaaatggag gcttttcact   4680

gcctgtagag acaatacagt aagcatagtt aaggggtggg tcagaacatg ttaagataac   4740

ttactgtata tgtattccct tgtattttgt taaagctgga acatttgata tttttccatt   4800

tatttatgaa aaaatatgaa cctattttca tttgtacaag gtaattgttt tttaaagcaa   4860

gtcaccttag ggtggcttta attgtataag tcaagcacat gtaataaatt caaaacctgc   4920

agttaacagg atattagaca tcaatcctgg taaccaaata ttaaagattc tctttaaaaa   4980

agactgaaca tgtttacagg tttgaattag gctaaaaggt cttgcagtgg cttttcatgg   5040

cccttcaaat tggaatggaa ctactgtact ttgccatttt tctataaatc agtatttttt   5100

tttaattttg atatacattg tgtgaaaaaa gaaaatggct aataaactgt attaaatctt   5160

aaacaatgta taaagattgt acttagccag ttcaaagtgt atatttattc ataatgaatt   5220

ataacagtta tatttttgtg ttttcttgta aatgtttctt ttcccttaaa tacagataat   5280

tcatttgtat tgcttatttt attatgagct acaacaaaag gacttcagga acaagtaatg   5340

tattagtatg gttcaagatt gttgatagga actgtctcaa aaggatggtg gttattttaa   5400

atataaatag ctaatggggg tggtaggcct ataaaattaa atgccttgta taaaatccaa   5460

aatgaatgca aaattgtttt cacttgtatt gactttatgt tgtatgattc caatctctgt   5520

tctgtttggc acttgtattt aattcttcac ctttgtaaga catttgtata ttgtggatgt   5580

gttcattcaa gctatttaat atctggcact gttaatacac agtactttat tgtacagact   5640

gttttactgt tttaattgta gttctgtgta ctttttttgg atggggctgg catgttttct   5700

ttgtttcctg gcaatacgac gtgggaattt caatgcgttt tgttgtagat gctaacgtgt   5760

cagaatcctt tacattcaac ttttctaaga aaagcatttt cagtcttgta gtgtgtgctt   5820

acagtaacta attttgttga aaatggtttc aagttattca aatttgtaca ggactgtaaa   5880

gatttgttga cagcaaaatg ttgaagaaaa aagcttatag aataaaagct ataaagtata   5940

tattaggatc tgcaaacaat gaagaattat gtaatatatt gtacaaatgt aagcaaaggc   6000

tctgaaataa aatgccatag tttgtgaatc cttaaaaaaa aaaaaaaaaa aaaaaaaaaa   6060

aaaaa                                                               6065


<210>  440
<211>  1312
<212>  PRT
<213>  Homosapiens

<400>  440

Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Thr Val Gly Thr Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Thr Phe Arg His Asp Ser Ser Thr 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Thr Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro 
        115                 120                 125             


Glu His Phe Gly Thr Pro Val Ile Gly Lys Lys Thr Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Thr Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Thr Ser Asp Thr Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Thr Ile Pro Ala Asn Trp Lys Thr Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Asp Glu Thr Asn Lys Glu Glu Asp Glu Asp Asp Glu Glu Ala Glu Glu 
    530                 535                 540                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Asp Asn 
545                 550                 555                 560 


Asn Glu Glu Glu Glu Phe Glu Cys Tyr Pro Pro Gly Met Lys Val Gln 
                565                 570                 575     


Val Arg Tyr Gly Arg Gly Lys Asn Gln Lys Met Tyr Glu Ala Ser Ile 
            580                 585                 590         


Lys Asp Ser Asp Val Glu Gly Gly Glu Val Leu Tyr Leu Val His Tyr 
        595                 600                 605             


Cys Gly Trp Asn Val Arg Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile 
    610                 615                 620                 


Val Arg Pro Ala Asp Lys Asn Val Pro Lys Ile Lys His Arg Lys Lys 
625                 630                 635                 640 


Ile Lys Asn Lys Leu Asp Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser 
                645                 650                 655     


Pro Lys Asn Cys Lys Leu Arg Arg Leu Ser Lys Pro Pro Phe Gln Thr 
            660                 665                 670         


Asn Pro Ser Pro Glu Met Val Ser Lys Leu Asp Leu Thr Asp Ala Lys 
        675                 680                 685             


Asn Ser Asp Thr Ala His Ile Lys Ser Ile Glu Ile Thr Ser Ile Leu 
    690                 695                 700                 


Asn Gly Leu Gln Ala Ser Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu 
705                 710                 715                 720 


Asp Glu Arg Gly Ala Gln Asp Met Asp Asn Asn Gly Lys Glu Glu Ser 
                725                 730                 735     


Lys Ile Asp His Leu Thr Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu 
            740                 745                 750         


Glu Gln Asn Ser Ser Ser Leu Leu Glu Glu Asn Lys Val His Ala Asp 
        755                 760                 765             


Leu Val Ile Ser Lys Pro Val Ser Lys Ser Pro Glu Arg Leu Arg Lys 
    770                 775                 780                 


Asp Ile Glu Val Leu Ser Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val 
785                 790                 795                 800 


Thr Lys Lys Arg Lys Asp Val Lys Lys Asp Thr Thr Asp Lys Ser Ser 
                805                 810                 815     


Lys Pro Gln Ile Lys Arg Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu 
            820                 825                 830         


Cys Leu Lys Thr Gly Ser Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn 
        835                 840                 845             


Lys Glu Ser Leu Cys Met Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu 
    850                 855                 860                 


Asp Glu Glu Glu Thr Lys Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn 
865                 870                 875                 880 


Gly Leu Glu Glu Lys Arg Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser 
                885                 890                 895     


Gly Phe Ser Glu Val Ala Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser 
            900                 905                 910         


Asp Glu Arg Leu Gln Asn Ser Arg Ala Lys Asp Arg Lys Asp Val Trp 
        915                 920                 925             


Ser Ser Ile Gln Gly Gln Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe 
    930                 935                 940                 


Ser Asp Ser Asp Thr Glu Ala Ala Ala Ser Pro Pro His Pro Ala Pro 
945                 950                 955                 960 


Glu Glu Gly Val Ala Glu Glu Ser Leu Gln Thr Val Ala Glu Glu Glu 
                965                 970                 975     


Ser Cys Ser Pro Ser Val Glu Leu Glu Lys Pro Pro Pro Val Asn Val 
            980                 985                 990         


Asp Ser Lys Pro Ile Glu Glu Lys  Thr Val Glu Val Asn  Asp Arg Lys 
        995                 1000                 1005             


Ala Glu  Phe Pro Ser Ser Gly  Ser Asn Ser Val Leu  Asn Thr Pro 
    1010                 1015                 1020             


Pro Thr  Thr Pro Glu Ser Pro  Ser Ser Val Thr Val  Thr Glu Gly 
    1025                 1030                 1035             


Ser Arg  Gln Gln Ser Ser Val  Thr Val Ser Glu Pro  Leu Ala Pro 
    1040                 1045                 1050             


Asn Gln  Glu Glu Val Arg Ser  Ile Lys Ser Glu Thr  Asp Ser Thr 
    1055                 1060                 1065             


Ile Glu  Val Asp Ser Val Ala  Gly Glu Leu Gln Asp  Leu Gln Ser 
    1070                 1075                 1080             


Glu Gly  Asn Ser Ser Pro Ala  Gly Phe Asp Ala Ser  Val Ser Ser 
    1085                 1090                 1095             


Ser Ser  Ser Asn Gln Pro Glu  Pro Glu His Pro Glu  Lys Ala Cys 
    1100                 1105                 1110             


Thr Gly  Gln Lys Arg Val Lys  Asp Ala Gln Gly Gly  Gly Ser Ser 
    1115                 1120                 1125             


Ser Lys  Lys Gln Lys Arg Ser  His Lys Ala Thr Val  Val Asn Asn 
    1130                 1135                 1140             


Lys Lys  Lys Gly Lys Gly Thr  Asn Ser Ser Asp Ser  Glu Glu Leu 
    1145                 1150                 1155             


Ser Ala  Gly Glu Ser Ile Thr  Lys Ser Gln Pro Val  Lys Ser Val 
    1160                 1165                 1170             


Ser Thr  Gly Met Lys Ser His  Ser Thr Lys Ser Pro  Ala Arg Thr 
    1175                 1180                 1185             


Gln Ser  Pro Gly Lys Cys Gly  Lys Asn Gly Asp Lys  Asp Pro Asp 
    1190                 1195                 1200             


Leu Lys  Glu Pro Ser Asn Arg  Leu Pro Lys Val Tyr  Lys Trp Ser 
    1205                 1210                 1215             


Phe Gln  Met Ser Asp Leu Glu  Asn Met Thr Ser Ala  Glu Arg Ile 
    1220                 1225                 1230             


Thr Ile  Leu Gln Glu Lys Leu  Gln Glu Ile Arg Lys  His Tyr Leu 
    1235                 1240                 1245             


Ser Leu  Lys Ser Glu Val Ala  Ser Ile Asp Arg Arg  Arg Lys Arg 
    1250                 1255                 1260             


Leu Lys  Lys Lys Glu Arg Glu  Ser Ala Ala Thr Ser  Ser Ser Ser 
    1265                 1270                 1275             


Ser Ser  Pro Ser Ser Ser Ser  Ile Thr Ala Ala Val  Met Leu Thr 
    1280                 1285                 1290             


Leu Ala  Glu Pro Ser Met Ser  Ser Ala Ser Gln Asn  Gly Met Ser 
    1295                 1300                 1305             


Val Glu  Cys Arg 
    1310         


<210>  441
<211>  5807
<212>  DNA
<213>  Homosapiens

<400>  441
agcgatgttt gcccgtcagt cgagtccgga gtgaggagct cggtcgccga agcggaggga     60

gactcttgag cttcatcttg ccgccgccac ggccaccgcc tggacctttg cccggaggga    120

gctgcagagg gtccatcgcc gccgtcctct ggagggcagc gcgattgggg gcccggacct    180

ccagtccggg ggggattttt cgtcgtcccc ctccccccaa ccagggagcc cgagcggccg    240

ccaaacaaag gtaccagtcg ccgccgcggg aggaggagga gccggagcct ctgcctcagc    300

agccgctgga cccgccgccc ttcttcccca tctctccccc gggcctgctg gttttggggg    360

ggagaaggag agaggggact ctggacgtgc cagggtcaga tctcgcctcc gaggaaggtg    420

cagctgaacc tggtgtttta gaggatacct tggtcccaga gtcatcatga aggcccttga    480

tgagcctccc tatttgacag tgggcactga tgtgagtgct aaatacagag gagccttttg    540

tgaagccaag atcaagacag caaaaagact tgtcaaagtc aaggtgacat ttagacatga    600

ttcttcaaca gtggaagttc aggatgacca cataaagggc ccactaaagg taggagctat    660

tgtggaagtg aagaatcttg atggtgcata tcaggaagct gttatcaata aactaacaga    720

tgcgagttgg tacactgtag tttttgatga cggagatgag aagacactga gacgatcttc    780

actgtgcctg aaaggagaga ggcattttgc tgaaagtgaa acattagacc agctcccact    840

caccaaccct gagcattttg gcactccagt cataggaaag aaaacaaata gaggaagaag    900

atctaatcat ataccagagg aagagtcttc atcatcctcc agtgatgaag atgaggatga    960

taggaaacag attgatgagc tactaggcaa agttgtatgt gtagattaca ttagtttgga   1020

taaaaagaaa gcactgtggt ttcctgcatt ggtggtttgt cctgattgta gtgatgagat   1080

tgctgtaaaa aaggacaata ttcttgttcg atctttcaaa gatggaaaat ttacttcagt   1140

tccaagaaaa gatgtccatg aaattactag tgacactgca ccaaagcctg atgctgtttt   1200

aaagcaagcc tttgaacagg cacttgaatt tcacaaaagt agaactattc ctgctaactg   1260

gaagactgaa ttgaaagaag atagctctag cagtgaagca gaggaagaag aggaggagga   1320

agatgatgaa aaagaaaagg aggataatag cagtgaagaa gaagaagaaa tagaaccatt   1380

tccagaagaa agggagaact ttcttcagca attgtacaaa tttatggaag atagaggtac   1440

acctattaac aaacgacctg tacttggata tcgaaatttg aatctcttta agttattcag   1500

acttgtacac aaacttggag gatttgataa tattgaaagt ggagctgttt ggaaacaagt   1560

ctaccaagat cttggaatcc ctgtcttaaa ttcagctgca ggatacaatg ttaaatgtgc   1620

ttataaaaaa tacttatatg gttttgagga gtactgtaga tcagccaaca ttgaatttca   1680

gatggcattg ccagagaaag ttgttaacaa gcaatgtaag gagtgtgaaa atgtaaaaga   1740

aataaaagtt aaggaggaaa atgaaacaga gatcaaagaa ataaagatgg aggaggagag   1800

gaatataata ccaagagaag aaaagcctat tgaggatgaa attgaaagaa aagaaaatat   1860

taagccctct ctgggaagta aaaagaattt attagaatct atacctacac attctgatca   1920

ggaaaaagaa gttaacatta aaaaaccaga agacaatgaa aatctggatg acaaagatga   1980

tgacacaact agggtagatg aatccctcaa cataaaggta gaagctgagg aagaaaaagc   2040

aaaatctgga tacgatgaat ggattaaagc agataaaata gtaagacctg ctgataaaaa   2100

tgtgccaaag ataaaacatc ggaagaaaat aaagaataaa ttagacaaag aaaaagacaa   2160

agatgaaaaa tactctccaa aaaactgtaa acttcggcgc ttgtccaaac caccatttca   2220

gacaaatcca tctcctgaaa tggtatccaa actggatctc actgatgcca aaaactctga   2280

tactgctcat attaagtcca tagaaattac ttcgatcctt aatggacttc aagcttctga   2340

aagttctgct gaagacagtg agcaggaaga tgagagaggt gctcaagaca tggataataa   2400

tggcaaagag gaatctaaga ttgatcattt gaccaacaac agaaatgatc ttatttcaaa   2460

ggaggaacag aacagttcat ctttgctaga agaaaacaaa gttcatgcag atttggtaat   2520

atccaaacca gtgtcaaaat ctccagaaag attaaggaaa gatatagaag tattatccga   2580

agatactgat tatgaagaag atgaagtcac aaaaaagaga aaggatgtca agaaggacac   2640

aacagataaa tcttcaaaac cacaaataaa acgtggtaaa agaaggtatt gcaatacaga   2700

agagtgtcta aaaactggat cacctggcaa aaaggaagag aaggccaaga acaaagaatc   2760

actttgcatg gaaaacagta gcaacagctc ttcagatgaa gatgaagaag aaacaaaagc   2820

aaagatgaca ccaactaaga aatacaatgg tttggaggaa aaaagaaaat ctctacggac   2880

aactggtttc tattcaggat tttcagaagt ggcagaaaaa aggattaaac ttttaaataa   2940

ctctgatgaa agacttcaaa acagcagggc caaagatcga aaagatgtct ggtcaagtat   3000

tcagggacag tggcctaaaa aaacgctgaa agagcttttt tcagactctg atactgaggc   3060

tgcagcttcc ccaccgcatc ctgccccaga ggagggggtg gcagaggagt cactgcagac   3120

tgtggctgaa gaggagagtt gttcacccag tgtagaacta gaaaaaccac ctccagtcaa   3180

tgtcgatagt aaacccattg aagaaaaaac agtagaggtc aatgacagaa aagcagaatt   3240

tccaagtagt ggcagtaatt cagtgctaaa tacccctcct actacacctg aatcgccttc   3300

atcagtcact gtaacagaag gcagccggca gcagtcttct gtaacagtat cagaaccact   3360

ggctccaaac caagaagagg ttcgaagtat caagagtgaa actgatagca caattgaggt   3420

ggatagtgtt gctggggagc tccaagacct ccagtctgaa gggaatagct cgccagcagg   3480

ttttgatgcc agtgtgagct caagcagtag taatcagcca gaaccagaac atcctgaaaa   3540

agcctgtaca ggtcagaaaa gagtgaaaga tgctcaggga ggaggaagtt catcaaaaaa   3600

gcagaaaaga agccataaag caacagtggt aaacaacaaa aagaagggaa aaggcacaaa   3660

tagtagtgat agtgaagaac tttcagctgg tgaaagtata actaagagtc agccagtcaa   3720

atcagtttcc actggaatga agtctcatag taccaaatct cccgcaagga cgcagtctcc   3780

aggaaaatgt ggaaagaatg gtgataagga tcctgatctc aaggaaccca gtaatcgatt   3840

acccaaagtt tacaaatgga gttttcagat gtcggacctg gaaaatatga caagtgccga   3900

acgcatcaca attcttcaag aaaaacttca agaaatcaga aaacattatc tgtcattaaa   3960

atctgaagta gcttccattg atcggaggag aaagcgttta aagaagaaag agagagaaag   4020

tgctgctaca tcctcatcct cctcttcacc ttcatccagt tccataacag ctgctgttat   4080

gttaacttta gctgaaccgt caatgtccag cgcatcacaa aatggaatgt cagttgagtg   4140

caggtgacag caggacttgc taaagcactt tgcacttaat ggctgttgag ggccactttt   4200

tttttatact gcacagtggc acaaaaaaat atcagacaag cactatttta tatttaaaaa   4260

ttgtttcttg acaagctgac ttggcactta agtgcacttt tttatgaaga aaaagtacaa   4320

tgaactgctt ttcctcaagc aataattgtt tccaacttgt ctgggaattg tgtgtctggt   4380

aactggaagg ccttccactg tggcaaatgg aggcttttca ctgcctgtag agacaataca   4440

gtaagcatag ttaaggggtg ggtcagaaca tgttaagata acttactgta tatgtattcc   4500

cttgtatttt gttaaagctg gaacatttga tatttttcca tttatttatg aaaaaatatg   4560

aacctatttt catttgtaca aggtaattgt tttttaaagc aagtcacctt agggtggctt   4620

taattgtata agtcaagcac atgtaataaa ttcaaaacct gcagttaaca ggatattaga   4680

catcaatcct ggtaaccaaa tattaaagat tctctttaaa aaagactgaa catgtttaca   4740

ggtttgaatt aggctaaaag gtcttgcagt ggcttttcat ggcccttcaa attggaatgg   4800

aactactgta ctttgccatt tttctataaa tcagtatttt tttttaattt tgatatacat   4860

tgtgtgaaaa aagaaaatgg ctaataaact gtattaaatc ttaaacaatg tataaagatt   4920

gtacttagcc agttcaaagt gtatatttat tcataatgaa ttataacagt tatatttttg   4980

tgttttcttg taaatgtttc ttttccctta aatacagata attcatttgt attgcttatt   5040

ttattatgag ctacaacaaa aggacttcag gaacaagtaa tgtattagta tggttcaaga   5100

ttgttgatag gaactgtctc aaaaggatgg tggttatttt aaatataaat agctaatggg   5160

ggtggtaggc ctataaaatt aaatgccttg tataaaatcc aaaatgaatg caaaattgtt   5220

ttcacttgta ttgactttat gttgtatgat tccaatctct gttctgtttg gcacttgtat   5280

ttaattcttc acctttgtaa gacatttgta tattgtggat gtgttcattc aagctattta   5340

atatctggca ctgttaatac acagtacttt attgtacaga ctgttttact gttttaattg   5400

tagttctgtg tacttttttt ggatggggct ggcatgtttt ctttgtttcc tggcaatacg   5460

acgtgggaat ttcaatgcgt tttgttgtag atgctaacgt gtcagaatcc tttacattca   5520

acttttctaa gaaaagcatt ttcagtcttg tagtgtgtgc ttacagtaac taattttgtt   5580

gaaaatggtt tcaagttatt caaatttgta caggactgta aagatttgtt gacagcaaaa   5640

tgttgaagaa aaaagcttat agaataaaag ctataaagta tatattagga tctgcaaaca   5700

atgaagaatt atgtaatata ttgtacaaat gtaagcaaag gctctgaaat aaaatgccat   5760

agtttgtgaa tccttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 5807


<210>  442
<211>  1226
<212>  PRT
<213>  Homosapiens

<400>  442

Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Thr Val Gly Thr Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Thr Phe Arg His Asp Ser Ser Thr 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Thr Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro 
        115                 120                 125             


Glu His Phe Gly Thr Pro Val Ile Gly Lys Lys Thr Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Thr Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Thr Ser Asp Thr Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Thr Ile Pro Ala Asn Trp Lys Thr Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile Val Arg Pro Ala Asp Lys 
    530                 535                 540                 


Asn Val Pro Lys Ile Lys His Arg Lys Lys Ile Lys Asn Lys Leu Asp 
545                 550                 555                 560 


Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser Pro Lys Asn Cys Lys Leu 
                565                 570                 575     


Arg Arg Leu Ser Lys Pro Pro Phe Gln Thr Asn Pro Ser Pro Glu Met 
            580                 585                 590         


Val Ser Lys Leu Asp Leu Thr Asp Ala Lys Asn Ser Asp Thr Ala His 
        595                 600                 605             


Ile Lys Ser Ile Glu Ile Thr Ser Ile Leu Asn Gly Leu Gln Ala Ser 
    610                 615                 620                 


Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu Asp Glu Arg Gly Ala Gln 
625                 630                 635                 640 


Asp Met Asp Asn Asn Gly Lys Glu Glu Ser Lys Ile Asp His Leu Thr 
                645                 650                 655     


Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu Glu Gln Asn Ser Ser Ser 
            660                 665                 670         


Leu Leu Glu Glu Asn Lys Val His Ala Asp Leu Val Ile Ser Lys Pro 
        675                 680                 685             


Val Ser Lys Ser Pro Glu Arg Leu Arg Lys Asp Ile Glu Val Leu Ser 
    690                 695                 700                 


Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val Thr Lys Lys Arg Lys Asp 
705                 710                 715                 720 


Val Lys Lys Asp Thr Thr Asp Lys Ser Ser Lys Pro Gln Ile Lys Arg 
                725                 730                 735     


Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu Cys Leu Lys Thr Gly Ser 
            740                 745                 750         


Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn Lys Glu Ser Leu Cys Met 
        755                 760                 765             


Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu Asp Glu Glu Glu Thr Lys 
    770                 775                 780                 


Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn Gly Leu Glu Glu Lys Arg 
785                 790                 795                 800 


Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser Gly Phe Ser Glu Val Ala 
                805                 810                 815     


Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser Asp Glu Arg Leu Gln Asn 
            820                 825                 830         


Ser Arg Ala Lys Asp Arg Lys Asp Val Trp Ser Ser Ile Gln Gly Gln 
        835                 840                 845             


Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe Ser Asp Ser Asp Thr Glu 
    850                 855                 860                 


Ala Ala Ala Ser Pro Pro His Pro Ala Pro Glu Glu Gly Val Ala Glu 
865                 870                 875                 880 


Glu Ser Leu Gln Thr Val Ala Glu Glu Glu Ser Cys Ser Pro Ser Val 
                885                 890                 895     


Glu Leu Glu Lys Pro Pro Pro Val Asn Val Asp Ser Lys Pro Ile Glu 
            900                 905                 910         


Glu Lys Thr Val Glu Val Asn Asp Arg Lys Ala Glu Phe Pro Ser Ser 
        915                 920                 925             


Gly Ser Asn Ser Val Leu Asn Thr Pro Pro Thr Thr Pro Glu Ser Pro 
    930                 935                 940                 


Ser Ser Val Thr Val Thr Glu Gly Ser Arg Gln Gln Ser Ser Val Thr 
945                 950                 955                 960 


Val Ser Glu Pro Leu Ala Pro Asn Gln Glu Glu Val Arg Ser Ile Lys 
                965                 970                 975     


Ser Glu Thr Asp Ser Thr Ile Glu Val Asp Ser Val Ala Gly Glu Leu 
            980                 985                 990         


Gln Asp Leu Gln Ser Glu Gly Asn  Ser Ser Pro Ala Gly  Phe Asp Ala 
        995                 1000                 1005             


Ser Val  Ser Ser Ser Ser Ser  Asn Gln Pro Glu Pro  Glu His Pro 
    1010                 1015                 1020             


Glu Lys  Ala Cys Thr Gly Gln  Lys Arg Val Lys Asp  Ala Gln Gly 
    1025                 1030                 1035             


Gly Gly  Ser Ser Ser Lys Lys  Gln Lys Arg Ser His  Lys Ala Thr 
    1040                 1045                 1050             


Val Val  Asn Asn Lys Lys Lys  Gly Lys Gly Thr Asn  Ser Ser Asp 
    1055                 1060                 1065             


Ser Glu  Glu Leu Ser Ala Gly  Glu Ser Ile Thr Lys  Ser Gln Pro 
    1070                 1075                 1080             


Val Lys  Ser Val Ser Thr Gly  Met Lys Ser His Ser  Thr Lys Ser 
    1085                 1090                 1095             


Pro Ala  Arg Thr Gln Ser Pro  Gly Lys Cys Gly Lys  Asn Gly Asp 
    1100                 1105                 1110             


Lys Asp  Pro Asp Leu Lys Glu  Pro Ser Asn Arg Leu  Pro Lys Val 
    1115                 1120                 1125             


Tyr Lys  Trp Ser Phe Gln Met  Ser Asp Leu Glu Asn  Met Thr Ser 
    1130                 1135                 1140             


Ala Glu  Arg Ile Thr Ile Leu  Gln Glu Lys Leu Gln  Glu Ile Arg 
    1145                 1150                 1155             


Lys His  Tyr Leu Ser Leu Lys  Ser Glu Val Ala Ser  Ile Asp Arg 
    1160                 1165                 1170             


Arg Arg  Lys Arg Leu Lys Lys  Lys Glu Arg Glu Ser  Ala Ala Thr 
    1175                 1180                 1185             


Ser Ser  Ser Ser Ser Ser Pro  Ser Ser Ser Ser Ile  Thr Ala Ala 
    1190                 1195                 1200             


Val Met  Leu Thr Leu Ala Glu  Pro Ser Met Ser Ser  Ala Ser Gln 
    1205                 1210                 1215             


Asn Gly  Met Ser Val Glu Cys  Arg 
    1220                 1225     


<210>  443
<211>  2757
<212>  DNA
<213>  Homosapiens

<400>  443
cgcgcaaatc ctcgtccgcg agaactgcaa ggcccgcaat gccctgcgcc tgcgtggacc     60

gattagcttt gaagtttaaa tccaatggag aagactcaag aaacagtcca aagaattctt    120

ctagaaccct ataaatactt acttcagtta ccaggtaaac aagtgagaac caaactttca    180

caggcattta atcattggct gaaagttcca gaggacaagc tacagattat tattgaagtg    240

acagaaatgt tgcataatgc cagtttactc atcgatgata ttgaagacaa ctcaaaactc    300

cgacgtggct ttccagtggc ccacagcatc tatggaatcc catctgtcat caattctgcc    360

aattacgtgt atttccttgg cttggagaaa gtcttaaccc ttgatcaccc agatgcagtg    420

aagcttttta cccgccagct tttggaactc catcagggac aaggcctaga tatttactgg    480

agggataatt acacttgtcc cactgaagaa gaatataaag ctatggtgct gcagaaaaca    540

ggtggactgt ttggattagc agtaggtctc atgcagttgt tctctgatta caaagaagat    600

ttaaaaccgc tacttaatac acttgggctc tttttccaaa ttagggatga ttatgctaat    660

ctacactcca aagaatatag tgaaaacaaa agtttttgtg aagatctgac agagggaaag    720

ttctcatttc ctactattca tgctatttgg tcaaggcctg aaagcaccca ggtgcagaat    780

atcttgcgcc agagaacaga aaacatagat ataaaaaaat actgtgtaca ttatcttgag    840

gatgtaggtt cttttgaata cactcgtaat acccttaaag agcttgaagc taaagcctat    900

aaacagattg atgcacgtgg tgggaaccct gagctagtag ccttagtaaa acacttaagt    960

aagatgttca aagaagaaaa tgaataatgt taagccattc ttgattggac ctcatagctt   1020

attttagtta atcttttttt tgtcttttag ccttaccacc ttttaaaaaa tttgttattc   1080

tccagaaaca gtaaataggt gagtaggggt ggtgcaagtg aattcgtttt catttagaag   1140

cccctctgta cagataatca aaattcaaag ttgaaagaat caaaagcagc cacagttatg   1200

taggtctgat ttgaatgtca taattgcagt gacaggacat tgccaccaac tctatcctac   1260

taccatcaat gttgtgttta ttccgtcaat aaaaaagact tgcttccagg aatttttatc   1320

catacacttt ctaactgtac tatctgggca gttccaagcc agtttctatt agctagctgg   1380

accaaagacc acaaatctct ttttttccta aacgctgctg taaggaatat ctcacttttc   1440

cccccggaaa caccctcact gaagtcttct atgaaaaggc tgataatggg ctgggcgcgg   1500

tggctcacgc ctgtaatccc agcactttgg gaggccgagg cgggcagatc acgaggtcag   1560

gagatcgaga ccatcctgac acggtgaaac cctgtctcta ctaaaaatac aaaaaattag   1620

ctgggcgtgg tggtgggcgc ctgtagtccc agctactcgg gaggctgagg caggagaatg   1680

gtgtgaaccc aggaggcgga gcttgcagtg agccgagata gtgcctctgc actccagcct   1740

gggtgacaga gcgagactcc gtctcaaaaa aaagggctga taatgataaa cagtgagcac   1800

tccggtcctt tttcttaggt tttccttttt tccttcctct ccaccccaca agttttgctt   1860

tttaaccaag gtgtctctgc ttgatgaaat tcacatgcta gtctaaatct ttttttctcc   1920

cttgtaacat ttatgtgccc caaactggtt agtatatggg tacagcattc cctttccaat   1980

tgggaagcgg aaaaagagag tatgggatat tttagaaggg agcctttgaa ccttattata   2040

tttccccatc attgatagtg acaatcttaa aagggttgtt ttcttacctt aagtacaaaa   2100

gcatggaaaa atgcgctttt ccttcccgcc cacatcacca ccccgacttg aagacagtag   2160

gtgcttgaat ggaaagtgag taggcatctt taatcgccct gattaaagga aagtgttagc   2220

ctgagagggc ctgactgaaa agtaaccaaa ggcttaatat caaacactaa ttagcttttt   2280

agtgccttaa ccctgacctg gttaccagtt ttctgtagtt tctacaccca agccactgaa   2340

gtcatctgtg gcccaagagg taggacaaaa aaaaaaaaaa aaaaagctga tttcaatatt   2400

tgatttgttg acatcccaaa atgaaagttt tatgtttccc ttagaaacat gttttgcttg   2460

gttctatagt atgttactta ggatctattt accatatatt tgtatgagaa atcctcaccc   2520

aagcattcaa cctaaatctt tgaaaagttg ggtgctgtct ttagtaactt ttaaaatagt   2580

ttaaatctcc cattttaata gtgataagga aacctgttaa aatcatggct attgatgtta   2640

tagtatggaa agttgaactt tatgaaccca tacttttaaa aagcattttt aaaaatctaa   2700

cactgactat agaaacaaat taaaatgtct acctttaagt ataaaaaaaa aaaaaaa      2757


<210>  444
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  444

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  445
<211>  2828
<212>  DNA
<213>  Homosapiens

<400>  445
gcaacgacgc ctgcgcagtg tgaccgggat ggcgcatttt cttgcaccaa ctaatgcggt     60

gtcgctggcg gctgaggagg gcggagagtt ctgtggtgaa atagtgggaa ggattcatgt    120

aggcatcggg aagagcctaa gtccacatta taaaatagga agttgatgcg gggtacagtt    180

actcccggac cggcggcgtg aaagtcgtga tatcatcgtt gaactgtaaa caagtgagaa    240

ccaaactttc acaggcattt aatcattggc tgaaagttcc agaggacaag ctacagatta    300

ttattgaagt gacagaaatg ttgcataatg ccagtttact catcgatgat attgaagaca    360

actcaaaact ccgacgtggc tttccagtgg cccacagcat ctatggaatc ccatctgtca    420

tcaattctgc caattacgtg tatttccttg gcttggagaa agtcttaacc cttgatcacc    480

cagatgcagt gaagcttttt acccgccagc ttttggaact ccatcaggga caaggcctag    540

atatttactg gagggataat tacacttgtc ccactgaaga agaatataaa gctatggtgc    600

tgcagaaaac aggtggactg tttggattag cagtaggtct catgcagttg ttctctgatt    660

acaaagaaga tttaaaaccg ctacttaata cacttgggct ctttttccaa attagggatg    720

attatgctaa tctacactcc aaagaatata gtgaaaacaa aagtttttgt gaagatctga    780

cagagggaaa gttctcattt cctactattc atgctatttg gtcaaggcct gaaagcaccc    840

aggtgcagaa tatcttgcgc cagagaacag aaaacataga tataaaaaaa tactgtgtac    900

attatcttga ggatgtaggt tcttttgaat acactcgtaa tacccttaaa gagcttgaag    960

ctaaagccta taaacagatt gatgcacgtg gtgggaaccc tgagctagta gccttagtaa   1020

aacacttaag taagatgttc aaagaagaaa atgaataatg ttaagccatt cttgattgga   1080

cctcatagct tattttagtt aatctttttt ttgtctttta gccttaccac cttttaaaaa   1140

atttgttatt ctccagaaac agtaaatagg tgagtagggg tggtgcaagt gaattcgttt   1200

tcatttagaa gcccctctgt acagataatc aaaattcaaa gttgaaagaa tcaaaagcag   1260

ccacagttat gtaggtctga tttgaatgtc ataattgcag tgacaggaca ttgccaccaa   1320

ctctatccta ctaccatcaa tgttgtgttt attccgtcaa taaaaaagac ttgcttccag   1380

gaatttttat ccatacactt tctaactgta ctatctgggc agttccaagc cagtttctat   1440

tagctagctg gaccaaagac cacaaatctc tttttttcct aaacgctgct gtaaggaata   1500

tctcactttt ccccccggaa acaccctcac tgaagtcttc tatgaaaagg ctgataatgg   1560

gctgggcgcg gtggctcacg cctgtaatcc cagcactttg ggaggccgag gcgggcagat   1620

cacgaggtca ggagatcgag accatcctga cacggtgaaa ccctgtctct actaaaaata   1680

caaaaaatta gctgggcgtg gtggtgggcg cctgtagtcc cagctactcg ggaggctgag   1740

gcaggagaat ggtgtgaacc caggaggcgg agcttgcagt gagccgagat agtgcctctg   1800

cactccagcc tgggtgacag agcgagactc cgtctcaaaa aaaagggctg ataatgataa   1860

acagtgagca ctccggtcct ttttcttagg ttttcctttt ttccttcctc tccaccccac   1920

aagttttgct ttttaaccaa ggtgtctctg cttgatgaaa ttcacatgct agtctaaatc   1980

tttttttctc ccttgtaaca tttatgtgcc ccaaactggt tagtatatgg gtacagcatt   2040

ccctttccaa ttgggaagcg gaaaaagaga gtatgggata ttttagaagg gagcctttga   2100

accttattat atttccccat cattgatagt gacaatctta aaagggttgt tttcttacct   2160

taagtacaaa agcatggaaa aatgcgcttt tccttcccgc ccacatcacc accccgactt   2220

gaagacagta ggtgcttgaa tggaaagtga gtaggcatct ttaatcgccc tgattaaagg   2280

aaagtgttag cctgagaggg cctgactgaa aagtaaccaa aggcttaata tcaaacacta   2340

attagctttt tagtgcctta accctgacct ggttaccagt tttctgtagt ttctacaccc   2400

aagccactga agtcatctgt ggcccaagag gtaggacaaa aaaaaaaaaa aaaaaagctg   2460

atttcaatat ttgatttgtt gacatcccaa aatgaaagtt ttatgtttcc cttagaaaca   2520

tgttttgctt ggttctatag tatgttactt aggatctatt taccatatat ttgtatgaga   2580

aatcctcacc caagcattca acctaaatct ttgaaaagtt gggtgctgtc tttagtaact   2640

tttaaaatag tttaaatctc ccattttaat agtgataagg aaacctgtta aaatcatggc   2700

tattgatgtt atagtatgga aagttgaact ttatgaaccc atacttttaa aaagcatttt   2760

taaaaatcta acactgacta tagaaacaaa ttaaaatgtc tacctttaag tataaaaaaa   2820

aaaaaaaa                                                            2828


<210>  446
<211>  246
<212>  PRT
<213>  Homosapiens

<400>  446

Met Leu His Asn Ala Ser Leu Leu Ile Asp Asp Ile Glu Asp Asn Ser 
1               5                   10                  15      


Lys Leu Arg Arg Gly Phe Pro Val Ala His Ser Ile Tyr Gly Ile Pro 
            20                  25                  30          


Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr Phe Leu Gly Leu Glu Lys 
        35                  40                  45              


Val Leu Thr Leu Asp His Pro Asp Ala Val Lys Leu Phe Thr Arg Gln 
    50                  55                  60                  


Leu Leu Glu Leu His Gln Gly Gln Gly Leu Asp Ile Tyr Trp Arg Asp 
65                  70                  75                  80  


Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr Lys Ala Met Val Leu Gln 
                85                  90                  95      


Lys Thr Gly Gly Leu Phe Gly Leu Ala Val Gly Leu Met Gln Leu Phe 
            100                 105                 110         


Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu Leu Asn Thr Leu Gly Leu 
        115                 120                 125             


Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn Leu His Ser Lys Glu Tyr 
    130                 135                 140                 


Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu Thr Glu Gly Lys Phe Ser 
145                 150                 155                 160 


Phe Pro Thr Ile His Ala Ile Trp Ser Arg Pro Glu Ser Thr Gln Val 
                165                 170                 175     


Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn Ile Asp Ile Lys Lys Tyr 
            180                 185                 190         


Cys Val His Tyr Leu Glu Asp Val Gly Ser Phe Glu Tyr Thr Arg Asn 
        195                 200                 205             


Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr Lys Gln Ile Asp Ala Arg 
    210                 215                 220                 


Gly Gly Asn Pro Glu Leu Val Ala Leu Val Lys His Leu Ser Lys Met 
225                 230                 235                 240 


Phe Lys Glu Glu Asn Glu 
                245     


<210>  447
<211>  2921
<212>  DNA
<213>  Homosapiens

<400>  447
gcaacgacgc ctgcgcagtg tgaccgggat ggcgcatttt cttgcaccaa ctaatgcggt     60

gtcgctggcg gctgaggagg gcggagagtt ctgtggtgaa atagtgggaa ggattcatgt    120

aggcatcggg aagagcctaa gtccacatta taaaatagga agttgatgcg gggtacagtt    180

actcccggac cggcggcgtg aaagtcgtga tatcatcgtt gaactattag ctttgaagtt    240

taaatccaat ggagaagact caagaaacag tccaaagaat tcttctagaa ccctataaat    300

acttacttca gttaccaggt aaacaagtga gaaccaaact ttcacaggca tttaatcatt    360

ggctgaaagt tccagaggac aagctacaga ttattattga agtgacagaa atgttgcata    420

atgccagttt actcatcgat gatattgaag acaactcaaa actccgacgt ggctttccag    480

tggcccacag catctatgga atcccatctg tcatcaattc tgccaattac gtgtatttcc    540

ttggcttgga gaaagtctta acccttgatc acccagatgc agtgaagctt tttacccgcc    600

agcttttgga actccatcag ggacaaggcc tagatattta ctggagggat aattacactt    660

gtcccactga agaagaatat aaagctatgg tgctgcagaa aacaggtgga ctgtttggat    720

tagcagtagg tctcatgcag ttgttctctg attacaaaga agatttaaaa ccgctactta    780

atacacttgg gctctttttc caaattaggg atgattatgc taatctacac tccaaagaat    840

atagtgaaaa caaaagtttt tgtgaagatc tgacagaggg aaagttctca tttcctacta    900

ttcatgctat ttggtcaagg cctgaaagca cccaggtgca gaatatcttg cgccagagaa    960

cagaaaacat agatataaaa aaatactgtg tacattatct tgaggatgta ggttcttttg   1020

aatacactcg taataccctt aaagagcttg aagctaaagc ctataaacag attgatgcac   1080

gtggtgggaa ccctgagcta gtagccttag taaaacactt aagtaagatg ttcaaagaag   1140

aaaatgaata atgttaagcc attcttgatt ggacctcata gcttatttta gttaatcttt   1200

tttttgtctt ttagccttac caccttttaa aaaatttgtt attctccaga aacagtaaat   1260

aggtgagtag gggtggtgca agtgaattcg ttttcattta gaagcccctc tgtacagata   1320

atcaaaattc aaagttgaaa gaatcaaaag cagccacagt tatgtaggtc tgatttgaat   1380

gtcataattg cagtgacagg acattgccac caactctatc ctactaccat caatgttgtg   1440

tttattccgt caataaaaaa gacttgcttc caggaatttt tatccataca ctttctaact   1500

gtactatctg ggcagttcca agccagtttc tattagctag ctggaccaaa gaccacaaat   1560

ctcttttttt cctaaacgct gctgtaagga atatctcact tttccccccg gaaacaccct   1620

cactgaagtc ttctatgaaa aggctgataa tgggctgggc gcggtggctc acgcctgtaa   1680

tcccagcact ttgggaggcc gaggcgggca gatcacgagg tcaggagatc gagaccatcc   1740

tgacacggtg aaaccctgtc tctactaaaa atacaaaaaa ttagctgggc gtggtggtgg   1800

gcgcctgtag tcccagctac tcgggaggct gaggcaggag aatggtgtga acccaggagg   1860

cggagcttgc agtgagccga gatagtgcct ctgcactcca gcctgggtga cagagcgaga   1920

ctccgtctca aaaaaaaggg ctgataatga taaacagtga gcactccggt cctttttctt   1980

aggttttcct tttttccttc ctctccaccc cacaagtttt gctttttaac caaggtgtct   2040

ctgcttgatg aaattcacat gctagtctaa atcttttttt ctcccttgta acatttatgt   2100

gccccaaact ggttagtata tgggtacagc attccctttc caattgggaa gcggaaaaag   2160

agagtatggg atattttaga agggagcctt tgaaccttat tatatttccc catcattgat   2220

agtgacaatc ttaaaagggt tgttttctta ccttaagtac aaaagcatgg aaaaatgcgc   2280

ttttccttcc cgcccacatc accaccccga cttgaagaca gtaggtgctt gaatggaaag   2340

tgagtaggca tctttaatcg ccctgattaa aggaaagtgt tagcctgaga gggcctgact   2400

gaaaagtaac caaaggctta atatcaaaca ctaattagct ttttagtgcc ttaaccctga   2460

cctggttacc agttttctgt agtttctaca cccaagccac tgaagtcatc tgtggcccaa   2520

gaggtaggac aaaaaaaaaa aaaaaaaaag ctgatttcaa tatttgattt gttgacatcc   2580

caaaatgaaa gttttatgtt tcccttagaa acatgttttg cttggttcta tagtatgtta   2640

cttaggatct atttaccata tatttgtatg agaaatcctc acccaagcat tcaacctaaa   2700

tctttgaaaa gttgggtgct gtctttagta acttttaaaa tagtttaaat ctcccatttt   2760

aatagtgata aggaaacctg ttaaaatcat ggctattgat gttatagtat ggaaagttga   2820

actttatgaa cccatacttt taaaaagcat ttttaaaaat ctaacactga ctatagaaac   2880

aaattaaaat gtctaccttt aagtataaaa aaaaaaaaaa a                       2921


<210>  448
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  448

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  449
<211>  1882
<212>  DNA
<213>  Homosapiens

<400>  449
gttggctgga ggggctgctg ctgggaacac ctggagtctc cgcgggcaga tctcatattt     60

tggattctgg atatattata atgagtgaca ctttgacagc ggatgtcatt ggtcgaagag    120

ttgaagttaa tggagaacat gcaacagtac gttttgctgg tgttgtccct cccgtggcag    180

gaccctggtt aggagtagaa tgggacaatc ccgagagagg aaagcatgat gggagccacg    240

aagggactgt gtattttaaa tgcaggcacc cgacaggagg atcctttatt cgtccgaaca    300

aggtaaattt tggaacagac tttcttactg caattaagaa ccgctatgtg ttagaagatg    360

gaccagagga agatagaaaa gagcaaattg ttacaattgg aaataaacct gtggagacta    420

tcggttttga ctctattatg aaacagcaaa gtcagctgag caagttgcaa gaagtttctc    480

tgaggaactg tgcagtaagt tgtgctggtg aaaaaggagg agttgctgaa gcatgtccta    540

atatcagaaa ggtagatttg tcaaaaaacc tgttgtcatc atgggatgaa gtgatacaca    600

ttgctgatca gctcagacac ctggaagtcc ttaatgtcag tgaaaataaa ctaaaatttc    660

cctccggttc agtattaact ggaacgcttt ctgtactgaa ggttttagtc ctcaatcaaa    720

caggaataac gtgggctgag gtgctgcggt gtgtcgcggg gtgcccaggc ctggaggaac    780

tctaccttga gtctaacaac attttcattt ccgaaaggcc aacagatgtt ctccagacag    840

tcaagttatt agatctttcc tctaatcaat taattgatga aaatcagctg tatctgatag    900

cccacctgcc caggttagaa caattaatcc tctctgacac tggaatttct tctctacatt    960

ttccggatgc tggaattggg tgcaaaacgt ccatgttccc atccttgaag tacctggtag   1020

taaacgacaa tcagatatca caatggtcgt ttttcaatga gctagagaag ttaccaagtc   1080

tacgggcttt gtcctgccta agaaaccccc tgaccaaaga ggacaaagaa gcagagacgg   1140

cgcgactact cattatcgcc agcattggcc agctgaagac gctgaacaaa tgtgagattc   1200

tccccgagga gaggcggaga gctgagcttg actaccgaaa agcttttgga aatgagtgga   1260

aacaggctgg tggacataag gatccggaaa aaaacagact cagcgaagaa ttcctcacag   1320

cccatcccag ataccagttc ctctgcctga aatatggtgc acctgaagat tgggaactca   1380

aaacacagca accacttatg ctgaaaaacc agctactaac actgaagata aaataccctc   1440

atcaacttga tcagaaagtc ctggagaaac aactgccggg ctccatgaca attcaaaagg   1500

tgaagggatt gctgtcacgt cttctcaaag ttcctgtgtc agaccttctg ttgtcctatg   1560

aaagtcccaa aaagccgggc agagaaatcg agctggaaaa tgacctaaag tcattacagt   1620

tttattctgt ggaaaatgga gattgtctat tagtgcgatg gtgacaacca actaataaaa   1680

tttaaagacc acactgctta tcgtgtctgg ggttcaccgg aaataaatga ttcactggaa   1740

caattctact gtcaaaacaa agggggttta caacttgtcc taagtataac aagggatgta   1800

tttttagttg ggaagtgacc atttctaggc ttatacataa tagcaataat aaaggctttg   1860

aacctacaga aaaaaaaaaa aa                                            1882


<210>  450
<211>  527
<212>  PRT
<213>  Homosapiens

<400>  450

Met Ser Asp Thr Leu Thr Ala Asp Val Ile Gly Arg Arg Val Glu Val 
1               5                   10                  15      


Asn Gly Glu His Ala Thr Val Arg Phe Ala Gly Val Val Pro Pro Val 
            20                  25                  30          


Ala Gly Pro Trp Leu Gly Val Glu Trp Asp Asn Pro Glu Arg Gly Lys 
        35                  40                  45              


His Asp Gly Ser His Glu Gly Thr Val Tyr Phe Lys Cys Arg His Pro 
    50                  55                  60                  


Thr Gly Gly Ser Phe Ile Arg Pro Asn Lys Val Asn Phe Gly Thr Asp 
65                  70                  75                  80  


Phe Leu Thr Ala Ile Lys Asn Arg Tyr Val Leu Glu Asp Gly Pro Glu 
                85                  90                  95      


Glu Asp Arg Lys Glu Gln Ile Val Thr Ile Gly Asn Lys Pro Val Glu 
            100                 105                 110         


Thr Ile Gly Phe Asp Ser Ile Met Lys Gln Gln Ser Gln Leu Ser Lys 
        115                 120                 125             


Leu Gln Glu Val Ser Leu Arg Asn Cys Ala Val Ser Cys Ala Gly Glu 
    130                 135                 140                 


Lys Gly Gly Val Ala Glu Ala Cys Pro Asn Ile Arg Lys Val Asp Leu 
145                 150                 155                 160 


Ser Lys Asn Leu Leu Ser Ser Trp Asp Glu Val Ile His Ile Ala Asp 
                165                 170                 175     


Gln Leu Arg His Leu Glu Val Leu Asn Val Ser Glu Asn Lys Leu Lys 
            180                 185                 190         


Phe Pro Ser Gly Ser Val Leu Thr Gly Thr Leu Ser Val Leu Lys Val 
        195                 200                 205             


Leu Val Leu Asn Gln Thr Gly Ile Thr Trp Ala Glu Val Leu Arg Cys 
    210                 215                 220                 


Val Ala Gly Cys Pro Gly Leu Glu Glu Leu Tyr Leu Glu Ser Asn Asn 
225                 230                 235                 240 


Ile Phe Ile Ser Glu Arg Pro Thr Asp Val Leu Gln Thr Val Lys Leu 
                245                 250                 255     


Leu Asp Leu Ser Ser Asn Gln Leu Ile Asp Glu Asn Gln Leu Tyr Leu 
            260                 265                 270         


Ile Ala His Leu Pro Arg Leu Glu Gln Leu Ile Leu Ser Asp Thr Gly 
        275                 280                 285             


Ile Ser Ser Leu His Phe Pro Asp Ala Gly Ile Gly Cys Lys Thr Ser 
    290                 295                 300                 


Met Phe Pro Ser Leu Lys Tyr Leu Val Val Asn Asp Asn Gln Ile Ser 
305                 310                 315                 320 


Gln Trp Ser Phe Phe Asn Glu Leu Glu Lys Leu Pro Ser Leu Arg Ala 
                325                 330                 335     


Leu Ser Cys Leu Arg Asn Pro Leu Thr Lys Glu Asp Lys Glu Ala Glu 
            340                 345                 350         


Thr Ala Arg Leu Leu Ile Ile Ala Ser Ile Gly Gln Leu Lys Thr Leu 
        355                 360                 365             


Asn Lys Cys Glu Ile Leu Pro Glu Glu Arg Arg Arg Ala Glu Leu Asp 
    370                 375                 380                 


Tyr Arg Lys Ala Phe Gly Asn Glu Trp Lys Gln Ala Gly Gly His Lys 
385                 390                 395                 400 


Asp Pro Glu Lys Asn Arg Leu Ser Glu Glu Phe Leu Thr Ala His Pro 
                405                 410                 415     


Arg Tyr Gln Phe Leu Cys Leu Lys Tyr Gly Ala Pro Glu Asp Trp Glu 
            420                 425                 430         


Leu Lys Thr Gln Gln Pro Leu Met Leu Lys Asn Gln Leu Leu Thr Leu 
        435                 440                 445             


Lys Ile Lys Tyr Pro His Gln Leu Asp Gln Lys Val Leu Glu Lys Gln 
    450                 455                 460                 


Leu Pro Gly Ser Met Thr Ile Gln Lys Val Lys Gly Leu Leu Ser Arg 
465                 470                 475                 480 


Leu Leu Lys Val Pro Val Ser Asp Leu Leu Leu Ser Tyr Glu Ser Pro 
                485                 490                 495     


Lys Lys Pro Gly Arg Glu Ile Glu Leu Glu Asn Asp Leu Lys Ser Leu 
            500                 505                 510         


Gln Phe Tyr Ser Val Glu Asn Gly Asp Cys Leu Leu Val Arg Trp 
        515                 520                 525         


<210>  451
<211>  2022
<212>  DNA
<213>  Homosapiens

<400>  451
aggcggaggg ggcggggctt cggccggcta agccgcggcc acccgcggtc tgagggaccg     60

gaggagcggg gccgggagct gcgaggagcc ctccagacgt cgccgagcgc gagggcgggc    120

gtgctcggag tggtcgctcg tcagccgccg cccctcagtc tccgcacttg caggtcccct    180

ccctctccgc cgggacgcgg gagagcccgg ctcgcggcgg gggcggccaa tgcgaaactg    240

gctggtgctg ctgtgcccgt gtgtgctcgg ggccgcgctg cacctctggc tgcggctgcg    300

ctccccgccg cccgcctgcg cctccggggc cggccctgca gatcagttgg ccttatttcc    360

tcagtggaaa tctactcact atgatgtggt agttggcgtg ttgtcagctc gcaataacca    420

tgaacttcga aacgtgataa gaagcacctg gatgagacat ttgctacagc atcccacatt    480

aagtcaacgt gtgcttgtga agttcataat aggtgctcat ggctgtgaag tgcctgtgga    540

agacagggaa gatccttatt cctgtaaact actcaacatc acaaatccag ttttgaatca    600

ggaaattgaa gcgttcagtc tgtccgaaga cacttcatcg gggctgcctg aggatcgagt    660

tgtcagcgtg agtttccgag ttctctaccc catcgttatt accagtcttg gagtgttcta    720

cgatgccaat gatgtgggtt tccagaggaa catcactgtc aaactttatc aggcagaaca    780

agaggaggcc ctcttcattg ctcgcttcag tcctccaagc tgtggtgtgc aggtgaacaa    840

gctgtggtac aagcccgtgg aacaattcat cttaccagag agctttgaag gtacaatcgt    900

gtgggagagc caagacctcc acggccttgt gtcaagaaat ctccacaaag tgacagtgaa    960

tgatggaggg ggagttctca gagtcattac agctggggag ggtgcattgc ctcatgaatt   1020

cttggaaggt gtggagggag ttgcaggtgg ttttatatat actattcagg aaggtgatgc   1080

tctcttacac aaccttcatt ctcgccctca aagacttatt gatcatataa ggaatctcca   1140

tgaggaagat gccttactga aggaggaaag cagcatctat gatgatattg tttttgtgga   1200

tgttgtcgac acttatcgta atgttcctgc aaaattattg aacttctata gatggactgt   1260

ggaaacaacg agcttcaatt tgttgctgaa gacagatgat gactgttaca tagacctcga   1320

agctgtattt aataggattg tccaaaagaa tctggatggg cctaattttt ggtggggaaa   1380

tttcagactg aattgggcag ttgaccgaac cggaaagtgg caggagttgg agtacccgag   1440

ccccgcttac cctgcctttg catgtgggtc aggatatgtg atctccaagg acatcgtcaa   1500

gtggctggca agcaactcgg ggaggttaaa gacctatcag ggtgaagatg taagcatggg   1560

catctggatg gctgccatag gacctaaaag ataccaggac agtctgtggc tgtgtgagaa   1620

gacctgtgag acaggaatgc tgtcttctcc tcagtattct ccgtgggaac tgacggaact   1680

gtggaaactg aaggaacggt gcggtgatcc ttgtcgatgt caagcaagat aacagggact   1740

tgaattagca gagtctaaaa tcagggcagg caaacgataa tctgagtgca agtctgagga   1800

gtcccagggt ttagcagtag actgtatggt ctttcaagag agttccagac tggcactttc   1860

acccagaacc aatgcggtgt ttcttaatgt ttgcacaaat ttccttaaaa atcaacttgt   1920

actgtagcat aagaaaagtt tttatttatc tattggaaga ttatcagaaa aataccaagt   1980

tattttataa aagaaaaaat atttctaaaa aaaaaaaaaa aa                      2022


<210>  452
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  452

Met Arg Asn Trp Leu Val Leu Leu Cys Pro Cys Val Leu Gly Ala Ala 
1               5                   10                  15      


Leu His Leu Trp Leu Arg Leu Arg Ser Pro Pro Pro Ala Cys Ala Ser 
            20                  25                  30          


Gly Ala Gly Pro Ala Asp Gln Leu Ala Leu Phe Pro Gln Trp Lys Ser 
        35                  40                  45              


Thr His Tyr Asp Val Val Val Gly Val Leu Ser Ala Arg Asn Asn His 
    50                  55                  60                  


Glu Leu Arg Asn Val Ile Arg Ser Thr Trp Met Arg His Leu Leu Gln 
65                  70                  75                  80  


His Pro Thr Leu Ser Gln Arg Val Leu Val Lys Phe Ile Ile Gly Ala 
                85                  90                  95      


His Gly Cys Glu Val Pro Val Glu Asp Arg Glu Asp Pro Tyr Ser Cys 
            100                 105                 110         


Lys Leu Leu Asn Ile Thr Asn Pro Val Leu Asn Gln Glu Ile Glu Ala 
        115                 120                 125             


Phe Ser Leu Ser Glu Asp Thr Ser Ser Gly Leu Pro Glu Asp Arg Val 
    130                 135                 140                 


Val Ser Val Ser Phe Arg Val Leu Tyr Pro Ile Val Ile Thr Ser Leu 
145                 150                 155                 160 


Gly Val Phe Tyr Asp Ala Asn Asp Val Gly Phe Gln Arg Asn Ile Thr 
                165                 170                 175     


Val Lys Leu Tyr Gln Ala Glu Gln Glu Glu Ala Leu Phe Ile Ala Arg 
            180                 185                 190         


Phe Ser Pro Pro Ser Cys Gly Val Gln Val Asn Lys Leu Trp Tyr Lys 
        195                 200                 205             


Pro Val Glu Gln Phe Ile Leu Pro Glu Ser Phe Glu Gly Thr Ile Val 
    210                 215                 220                 


Trp Glu Ser Gln Asp Leu His Gly Leu Val Ser Arg Asn Leu His Lys 
225                 230                 235                 240 


Val Thr Val Asn Asp Gly Gly Gly Val Leu Arg Val Ile Thr Ala Gly 
                245                 250                 255     


Glu Gly Ala Leu Pro His Glu Phe Leu Glu Gly Val Glu Gly Val Ala 
            260                 265                 270         


Gly Gly Phe Ile Tyr Thr Ile Gln Glu Gly Asp Ala Leu Leu His Asn 
        275                 280                 285             


Leu His Ser Arg Pro Gln Arg Leu Ile Asp His Ile Arg Asn Leu His 
    290                 295                 300                 


Glu Glu Asp Ala Leu Leu Lys Glu Glu Ser Ser Ile Tyr Asp Asp Ile 
305                 310                 315                 320 


Val Phe Val Asp Val Val Asp Thr Tyr Arg Asn Val Pro Ala Lys Leu 
                325                 330                 335     


Leu Asn Phe Tyr Arg Trp Thr Val Glu Thr Thr Ser Phe Asn Leu Leu 
            340                 345                 350         


Leu Lys Thr Asp Asp Asp Cys Tyr Ile Asp Leu Glu Ala Val Phe Asn 
        355                 360                 365             


Arg Ile Val Gln Lys Asn Leu Asp Gly Pro Asn Phe Trp Trp Gly Asn 
    370                 375                 380                 


Phe Arg Leu Asn Trp Ala Val Asp Arg Thr Gly Lys Trp Gln Glu Leu 
385                 390                 395                 400 


Glu Tyr Pro Ser Pro Ala Tyr Pro Ala Phe Ala Cys Gly Ser Gly Tyr 
                405                 410                 415     


Val Ile Ser Lys Asp Ile Val Lys Trp Leu Ala Ser Asn Ser Gly Arg 
            420                 425                 430         


Leu Lys Thr Tyr Gln Gly Glu Asp Val Ser Met Gly Ile Trp Met Ala 
        435                 440                 445             


Ala Ile Gly Pro Lys Arg Tyr Gln Asp Ser Leu Trp Leu Cys Glu Lys 
    450                 455                 460                 


Thr Cys Glu Thr Gly Met Leu Ser Ser Pro Gln Tyr Ser Pro Trp Glu 
465                 470                 475                 480 


Leu Thr Glu Leu Trp Lys Leu Lys Glu Arg Cys Gly Asp Pro Cys Arg 
                485                 490                 495     


Cys Gln Ala Arg 
            500 


<210>  453
<211>  1734
<212>  DNA
<213>  Homosapiens

<400>  453
cggtgccaca gggacgaggc ctggagagca gtcgctccta gaaccggggc gcgaagggca     60

cccccgcctc cagcacgcgc cctccgccct cccggcctcg ctccccccgg agtgggggcc    120

tcgccggccc ctggtccccg tcactcagca acgtcgggtc agccttcgcc gggttagtgg    180

cgacgcggcc gcgcgaattc gcacaggggc agtagaatga aagagggcat gtctaataac    240

agcaccacta gcatctccca agccaggaaa gctgtggagc agctaaagat ggaagcctgt    300

atggacaggg tcaaggtctc ccaggcagct gcggacctcc tggcctactg tgaagctcac    360

gtgcgggaag atcctctcat cattccagtg cctgcatcag aaaacccctt tcgcgagaag    420

aagttctttt gtaccattct ctaactccgt gtgtgatgaa aacgcctcct tttctgacct    480

tcaaagtccc ctgtagagac catgcatgct ctaaacctta gggagtgaga ccaacaccca    540

tccctgccca gccagagtgg ccggggcttg tcttatgttt ccatctgttt tcttcgtggc    600

attcaatttc atttttttcc ttttcatttt catgttattt tcattattgg caaagaaaat    660

caaaatgttt atagccaaat aacaaatgtg ccatgtaaaa gtaagtctgg acttaagagt    720

ttaaaatttt taaacatcag tttccaagtt tatatcatat taatacattt cagtggataa    780

tttatttaaa aaaaaaaact atgcctaaat atcccttatt tgcaatattc agtatcaaat    840

tagagcattt tgaccaactg aaacatataa cgttttcatc tcctttcctg gagaaagcag    900

ctgcagaggt tctgtatttc ctgcatttcc atcatcctag taaaaagaca acaacccaca    960

ggattggaat ggttttcttt tgtttttttt ttgttgttgt tgttgttttg agatggagtc   1020

tcgctctgtc acccaggctg gagtgcaatg gcgtgacctc agctcactgc gacctccacc   1080

tcctgggttc aagcgattct cctgcctcag cctcctgagt agctgggatc ataggcacgc   1140

gccaccacac ccagctaatt ttttgtattt ttagtaaaga cggggtttca ccatgttggt   1200

caggctggtc tcaaactcct gacctcgtga tccacccgcc tcggcctccc aaagcgctgg   1260

gattacaggc gtgagccacc acacccggcc gtggaatggt tttcttagca tatcctcctg   1320

gggccgtggc gcccaggctg tgggccgtgg tggatgtccc ttgtttcagt ggtcctacaa   1380

aggtagatgg tgggcggaca ccgaagtcaa cttgactgta aaagtacccc ataccgttga   1440

cgcgctgtgg cagacctgtg ggtgcggtct cccctctcca aatgccacct cttcctgctc   1500

cctcctcttt tggctcctac tcagtagttc cattgtgggc tgcagtaata taaggacctg   1560

ttctggacac agcactgggc ccgctggggt tttagtaggg cagccccttc cctgcaggag   1620

tgaggcatgg tgacagcagt cccctatgtg cccccaagtc atctgagcat tggtgtgcat   1680

taaggtactc aatcttccaa caataaatac cataagtgca aaaaaaaaaa aaaa         1734


<210>  454
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  454

Met Lys Glu Gly Met Ser Asn Asn Ser Thr Thr Ser Ile Ser Gln Ala 
1               5                   10                  15      


Arg Lys Ala Val Glu Gln Leu Lys Met Glu Ala Cys Met Asp Arg Val 
            20                  25                  30          


Lys Val Ser Gln Ala Ala Ala Asp Leu Leu Ala Tyr Cys Glu Ala His 
        35                  40                  45              


Val Arg Glu Asp Pro Leu Ile Ile Pro Val Pro Ala Ser Glu Asn Pro 
    50                  55                  60                  


Phe Arg Glu Lys Lys Phe Phe Cys Thr Ile Leu 
65                  70                  75  


<210>  455
<211>  6644
<212>  DNA
<213>  Homosapiens

<400>  455
atgcattcga ttcgcacggt ggagattaaa gtccccgaga tagaggaaac gtttttcgcg     60

cccaggttca gcgaggagcc gcgcgggggc agagggggcg gcggcggcgg gcggggagcc    120

aggcccgagc tgcgttctgc gcagccattg gtgggcgccg cgctctgcac tgagcatgtt    180

cgcgccccgc cggcccctag ccgcagccgc agccgcagcg acggcagcca cgggagccgc    240

cgcgcattat gcaaagcggc ggcagatgcg agcggggcca gccgggcgcg cgtcggcctc    300

ccctcccagc ggctcccccc gccgccgcct gactctcccg ggagactccc taggcccgga    360

cctggggccg aggagggccg ggatggcctg agtgcccgcg gcgcggcggc gcagcagcgg    420

gattgcacca tggggaacca ggatgggaag ctgaagagga gcgcaggtga tgctttgcac    480

gaaggcggcg gtggcgccga ggatgcgctg gggcccaggg atgtggaagc cacaaagaag    540

gggagcgggg gcaagaaggc gctaggcaag cacggcaagg ggggaggggg cggcggcggc    600

ggcggggagt cgggcaagaa gaagagcaag tccgactcca gagcctcggt gttttccaac    660

ctgcggatca ggaagaatct gtccaagggg aaaggcgccg gcggctcccg cgaagatgta    720

ctggattccc aggccctgca gaccggggag ctggacagcg ctcactccct gctcaccaag    780

actccagacc tcagcctctc ggcggacgag gccggcctgt cggataccga gtgtgcggac    840

ccttttgagg tgaccggtcc agggggtcct gggcctgccg aggctagggt cgggggccgg    900

ccgatcgccg aggatgtgga aactgcagca ggggcgcagg atggacaaag gaccagctcg    960

ggctcggaca cggacatcta tagcttccat tcggctacgg agcaagagga tttgctttca   1020

gacatccagc aggcgatccg cctgcagcag cagcagcagc agcagctcca gctccagctc   1080

cagcaacagc agcagcagca gcagctccag ggcgccgagg agcctgcagc gccccccact   1140

gccgtctccc ctcagcccgg ggccttcctg ggcctggacc ggttcctgct ggggccgagc   1200

ggcggggctg gggaggcccc gggcagtccg gacaccgagc aggcgctgtc cgcgctctcc   1260

gacctgcccg agagcctggc cgccgagccc cgggagcccc agcaaccgcc gtcccccggc   1320

ggcctcccgg tctccgaggc gcccagtctc ccggcagcgc aacccgcggc caaagactcg   1380

ccctcctcca cggctttccc atttcccgag gccgggccgg gggaggaagc ggccggagcc   1440

cccgtgcgag gggctgggga cacggatgag gagggtgagg aggatgcttt tgaggatgcg   1500

ccccggggct ctccggggga ggagtgggcc ccggaggtgg gagaggacgc cccgcagagg   1560

ctgggggaag agccggagga ggaggcgcaa ggacctgacg cccccgcggc cgcttccctg   1620

cccggcagcc ccgcgcctag ccagcgctgt ttcaagccct acccgctcat caccccctgc   1680

tacatcaaga ccaccacccg gcagctcagc tcgcccaatc actccccgtc tcagtcccct   1740

aatcagagcc ccaggatcaa gaggcggccg gaaccctccc tgagccgagg gtccagaact   1800

gccctggcct ccgtagccgc cccggccaag aagcaccggg ccgacggcgg ccttgcggcc   1860

ggcctgagcc gctcggctga ctggacggag gagctaggcg cccgcacgcc ccgggtggga   1920

ggctccgcgc acctgctgga gcgcggggtg gcgagtgaca gcggcggtgg ggtgtcccca   1980

gcactggccg ccaaggcgtc tggggccccc gcggctgcgg atggcttcca gaacgtgttc   2040

acagggcgaa cgctgttgga gaagctgttc agccagcagg agaacgggcc tccagaagaa   2100

gcagagaagt tttgctcccg gatcattgcc atgggtcttc tccttccttt tagtgattgc   2160

ttcagggaac cgtgtaatca gaatgcccag acgaatgcag cttcgtttga tcaagatcaa   2220

ctttatacct gggctgcagt tagtcaaccc acacactcat tggactattc agaagggcag   2280

tttcctaggc gagttccatc catggggcca ccatccaaac ctcccgatga ggaacacagg   2340

ctcgaggatg ctgaaacaga atctcaatct gctgtttcag aaactcccca aaaacgctca   2400

gatgctgtcc agaaggaagt tgttgacatg aagtctgagg gacaggccac tgtaattcag   2460

cagctggaac agactattga ggatctgaga accaaaatag ctgaactaga gaggcagtat   2520

cctgccctgg acacagaggt ggccagtggt catcaagggc ttgagaatgg agtgacagcc   2580

tcaggcgatg tctgtctcga agctctcagg ttagaagaaa aggaagtacg gcatcatagg   2640

attttagagg cgaaatcgat acagacttcc cccacggaag agggcggggt gctgacactg   2700

cctcctgtgg atgggctgcc agggcgtcct ccatgccccc ctggggctga aagtggacct   2760

cagacaaagt tctgttcaga gatttctttg attgtgtctc caaggcgaat atcagtccag   2820

ctcgacagcc atcagcccac acagagcatc tcacagcctc caccacctcc atcccttctg   2880

tggtctgctg ggcaaggaca gcctgggtca cagccgcccc attctatttc taccgagttt   2940

caaaccagcc acgaacactc tgtttcctct gcctttaaaa acagctgtaa catcccatct   3000

ccaccacctc tgccttgcac agagtcctcc agctccatgc ctggcctggg catggtgcct   3060

cccccacctc cccctctccc tggcatgaca gtgcctactc tgcccagtac agccattccc   3120

caacctcctc ctctgcaggg tacagaaatg ctgccacccc ctccccctcc tcttcccgga   3180

gcgggcatac ctcctccgcc gcctctaccc ggagcaggca tactccctct gccccctcta   3240

cccggagcgg gaatacctcc tccgccccct ctacccggag cggcaatacc ccctccgccc   3300

cctcttcccg gggcaggcat accccttcct ccccctcttc ccggagcagg aatacctcct   3360

ccaccccctc tacccggagc gggcataccc cctcctcccc cacttcccgg agcgggcata   3420

ccccctccgc ccccacttcc cggagcgggc ataccccctc ctccccctct tcccggagcg   3480

ggcatacctc ctccaccccc tctacccgga gcgggcatac cccctccgcc cccacttccc   3540

ggagcgggca taccccctcc gcccccactt cccggagcgg gcataccccc tcctccccct   3600

cttcccggag cgggcatacc tcctccaccc cctctacccg gagcgggcat accccctccg   3660

cccccacttc ccggagcggg cataccccca cctccccctc tacccggagc gggcataccc   3720

cctccgcccc ctctacccgg agtgggcata cctcctccgc cccctctacc cggagcgggc   3780

ataccccctc ctccccctct acccggagcg ggcatacccc ctcctccccc tcttcccgga   3840

gcgggcatac ctcctccacc ccctctaccc agagtgggca taccccctcc gcccccactt   3900

cccggagcgg gcataccccc acctccccct ctacccggag cgggcatacc ccctccgccc   3960

cctctacctg gagtgggaat acctcctccg ccccctctac ctggagtggg aatacctcct   4020

ccgccccctc tacctggtgc tgggattccc ccacctcctc ccttgccagg tatggggatt   4080

ccacctgctc cagctccccc actccctcca cctgggacag gaatcccacc gccccctctg   4140

cttcctgtat caggccctcc actcctccca caagttggga gtagcacttt accaacccca   4200

caggtgtgtg gatttcttcc tcctccattg ccaagtggct tgtttggatt agggatgaat   4260

caggacaaag ggagtaggaa gcagcccata gagccttgtc gaccaatgaa gcctctttac   4320

tggaccagga ttcaactaca tagtaaaaga gactccagta cttcacttat ttgggaaaaa   4380

attgaagagc catccataga ttgtcatgaa tttgaggaat tattttctaa aactgctgta   4440

aaggagagaa agaaacctat ctctgatact atctcaaaga cgaaggctaa acaagttgtc   4500

aagttattaa gcaacaaaag atcacaagca gttggaatac taatgtctag ccttcattta   4560

gatatgaaag acatacaaca tgctgttgtg aacttggata attctgtggt tgacctggag   4620

acccttcaag ctctctatga gaatagagca cagtcagacg aactcgaaaa aatagaaaag   4680

catggccgat cttccaaaga caaggaaaat gccaagtctc tggacaaacc tgaacagttc   4740

ctttatgaac tgtcactaat ccccaacttt tcagagcgag tcttttgcat cctgttccag   4800

tccacatttt cagaaagcat ttgctcaatt cgtcgcaaac tggaattact acagaaattg   4860

tgtgagacat taaaaaatgg cccaggggtt atgcaggttc taggtttggt tcttgccttt   4920

ggcaactaca tgaatggagg aaataagact cgaggacagg cagatggctt tggattagac   4980

attcttccaa aactgaaaga tgtcaagagc agtgacaata gcagaagcct tttgtcatat   5040

attgtttcgt attatctccg aaattttgat gaggatgctg gaaaagaaca gtgcctcttt   5100

ccactgccag aaccccagga cctttttcag gcctcacaga tgaagtttga agattttcaa   5160

aaagatctca gaaaactgaa gaaagacttg aaagcctgtg aagttgaagc agggaaagta   5220

taccaggtct cctcaaaaga gcatatgcag cctttcaagg aaaacatgga acaatttatt   5280

attcaagcca aaattgacca agaggcagag gaaaattcac tgacagagac tcataaatgc   5340

tttttggaga ccacggcata tttcttcatg aaaccaaaac ttggagagaa ggaggtgtcc   5400

ccaaatgctt tcttcagtat ctggcatgaa ttcagctctg actttaaaga cttctggaag   5460

aaagagaaca aacttcttct acaagagaga gtaaaagaag ccgaagaggt gtgtagacag   5520

aagaaaggaa aatcacttta taaaataaaa ccaagacatg actctggaat taaagcaaag   5580

ataagcatga aaacttgaac aatgaaaagc agaatgaaaa tgagtcattg caacgacttt   5640

cacaaaattc agctgacctg agagtgggag ggaaactacc gtcattctgc tcatgtttct   5700

tcttgacctc ttgcataatc tttttgtttt ctagacagtt cactaattgt tgaattttac   5760

tgtatattca tataaaaatg caaacgtact agaccagtgg agaatttgac accttttctt   5820

tttgtaaaag tttatggtat tataccgata gaccaaaaca gcatgtgtaa gaggcagtat   5880

ctgcactaat tctcaacatg ctaaacatta actacaattc actgttgtga gaatattcct   5940

cgtcacagca aaaacacttt cctttctact gacaaccagt cctccacatc acagcattta   6000

gacatatggg taaaatgtta tttctagtga attgtttgta tcagtttcat gtctaagtat   6060

aaattttcta ttttaaaatt taagaaccgt ttataatcag tgctttccca actcttgggt   6120

tgctctccat aactatgtat ttgtgaaaga aaatggtcat tttttttact gaagtcatat   6180

aatgacttgg gtcagctcgt aatgcattgt gatggttttg tatgagctgg gtgttttttt   6240

ccattacttt taatgatctt cgttgcaagt tatagttgtg gataaagggg agaatttatt   6300

gctcttgcaa accaattatg gaaagcaact taagaaaacc aatgttctaa atcataattg   6360

tttgtattta tgtaaagtat ggtctcttac tttttagttt gtagtttaag tgcaaagaaa   6420

cagtagtggt tttttttcta ttgttttgta gtcttcctgt ccccttcagt ccctccagtg   6480

tgtatattac cattctccaa tgaaataata gggcatttaa caaagatcgc tatgtgcaat   6540

actgtattta gtgtttctat ttcaattttt ctaggatgtt aatttatatg aaaataaaat   6600

gaataataaa agaataaaga tacttgcaaa agaaaaaaaa aaaa                    6644


<210>  456
<211>  1865
<212>  PRT
<213>  Homosapiens

<400>  456

Met His Ser Ile Arg Thr Val Glu Ile Lys Val Pro Glu Ile Glu Glu 
1               5                   10                  15      


Thr Phe Phe Ala Pro Arg Phe Ser Glu Glu Pro Arg Gly Gly Arg Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Arg Gly Ala Arg Pro Glu Leu Arg Ser Ala Gln 
        35                  40                  45              


Pro Leu Val Gly Ala Ala Leu Cys Thr Glu His Val Arg Ala Pro Pro 
    50                  55                  60                  


Ala Pro Ser Arg Ser Arg Ser Arg Ser Asp Gly Ser His Gly Ser Arg 
65                  70                  75                  80  


Arg Ala Leu Cys Lys Ala Ala Ala Asp Ala Ser Gly Ala Ser Arg Ala 
                85                  90                  95      


Arg Val Gly Leu Pro Ser Gln Arg Leu Pro Pro Pro Pro Pro Asp Ser 
            100                 105                 110         


Pro Gly Arg Leu Pro Arg Pro Gly Pro Gly Ala Glu Glu Gly Arg Asp 
        115                 120                 125             


Gly Leu Ser Ala Arg Gly Ala Ala Ala Gln Gln Arg Asp Cys Thr Met 
    130                 135                 140                 


Gly Asn Gln Asp Gly Lys Leu Lys Arg Ser Ala Gly Asp Ala Leu His 
145                 150                 155                 160 


Glu Gly Gly Gly Gly Ala Glu Asp Ala Leu Gly Pro Arg Asp Val Glu 
                165                 170                 175     


Ala Thr Lys Lys Gly Ser Gly Gly Lys Lys Ala Leu Gly Lys His Gly 
            180                 185                 190         


Lys Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ser Gly Lys Lys Lys 
        195                 200                 205             


Ser Lys Ser Asp Ser Arg Ala Ser Val Phe Ser Asn Leu Arg Ile Arg 
    210                 215                 220                 


Lys Asn Leu Ser Lys Gly Lys Gly Ala Gly Gly Ser Arg Glu Asp Val 
225                 230                 235                 240 


Leu Asp Ser Gln Ala Leu Gln Thr Gly Glu Leu Asp Ser Ala His Ser 
                245                 250                 255     


Leu Leu Thr Lys Thr Pro Asp Leu Ser Leu Ser Ala Asp Glu Ala Gly 
            260                 265                 270         


Leu Ser Asp Thr Glu Cys Ala Asp Pro Phe Glu Val Thr Gly Pro Gly 
        275                 280                 285             


Gly Pro Gly Pro Ala Glu Ala Arg Val Gly Gly Arg Pro Ile Ala Glu 
    290                 295                 300                 


Asp Val Glu Thr Ala Ala Gly Ala Gln Asp Gly Gln Arg Thr Ser Ser 
305                 310                 315                 320 


Gly Ser Asp Thr Asp Ile Tyr Ser Phe His Ser Ala Thr Glu Gln Glu 
                325                 330                 335     


Asp Leu Leu Ser Asp Ile Gln Gln Ala Ile Arg Leu Gln Gln Gln Gln 
            340                 345                 350         


Gln Gln Gln Leu Gln Leu Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
        355                 360                 365             


Leu Gln Gly Ala Glu Glu Pro Ala Ala Pro Pro Thr Ala Val Ser Pro 
    370                 375                 380                 


Gln Pro Gly Ala Phe Leu Gly Leu Asp Arg Phe Leu Leu Gly Pro Ser 
385                 390                 395                 400 


Gly Gly Ala Gly Glu Ala Pro Gly Ser Pro Asp Thr Glu Gln Ala Leu 
                405                 410                 415     


Ser Ala Leu Ser Asp Leu Pro Glu Ser Leu Ala Ala Glu Pro Arg Glu 
            420                 425                 430         


Pro Gln Gln Pro Pro Ser Pro Gly Gly Leu Pro Val Ser Glu Ala Pro 
        435                 440                 445             


Ser Leu Pro Ala Ala Gln Pro Ala Ala Lys Asp Ser Pro Ser Ser Thr 
    450                 455                 460                 


Ala Phe Pro Phe Pro Glu Ala Gly Pro Gly Glu Glu Ala Ala Gly Ala 
465                 470                 475                 480 


Pro Val Arg Gly Ala Gly Asp Thr Asp Glu Glu Gly Glu Glu Asp Ala 
                485                 490                 495     


Phe Glu Asp Ala Pro Arg Gly Ser Pro Gly Glu Glu Trp Ala Pro Glu 
            500                 505                 510         


Val Gly Glu Asp Ala Pro Gln Arg Leu Gly Glu Glu Pro Glu Glu Glu 
        515                 520                 525             


Ala Gln Gly Pro Asp Ala Pro Ala Ala Ala Ser Leu Pro Gly Ser Pro 
    530                 535                 540                 


Ala Pro Ser Gln Arg Cys Phe Lys Pro Tyr Pro Leu Ile Thr Pro Cys 
545                 550                 555                 560 


Tyr Ile Lys Thr Thr Thr Arg Gln Leu Ser Ser Pro Asn His Ser Pro 
                565                 570                 575     


Ser Gln Ser Pro Asn Gln Ser Pro Arg Ile Lys Arg Arg Pro Glu Pro 
            580                 585                 590         


Ser Leu Ser Arg Gly Ser Arg Thr Ala Leu Ala Ser Val Ala Ala Pro 
        595                 600                 605             


Ala Lys Lys His Arg Ala Asp Gly Gly Leu Ala Ala Gly Leu Ser Arg 
    610                 615                 620                 


Ser Ala Asp Trp Thr Glu Glu Leu Gly Ala Arg Thr Pro Arg Val Gly 
625                 630                 635                 640 


Gly Ser Ala His Leu Leu Glu Arg Gly Val Ala Ser Asp Ser Gly Gly 
                645                 650                 655     


Gly Val Ser Pro Ala Leu Ala Ala Lys Ala Ser Gly Ala Pro Ala Ala 
            660                 665                 670         


Ala Asp Gly Phe Gln Asn Val Phe Thr Gly Arg Thr Leu Leu Glu Lys 
        675                 680                 685             


Leu Phe Ser Gln Gln Glu Asn Gly Pro Pro Glu Glu Ala Glu Lys Phe 
    690                 695                 700                 


Cys Ser Arg Ile Ile Ala Met Gly Leu Leu Leu Pro Phe Ser Asp Cys 
705                 710                 715                 720 


Phe Arg Glu Pro Cys Asn Gln Asn Ala Gln Thr Asn Ala Ala Ser Phe 
                725                 730                 735     


Asp Gln Asp Gln Leu Tyr Thr Trp Ala Ala Val Ser Gln Pro Thr His 
            740                 745                 750         


Ser Leu Asp Tyr Ser Glu Gly Gln Phe Pro Arg Arg Val Pro Ser Met 
        755                 760                 765             


Gly Pro Pro Ser Lys Pro Pro Asp Glu Glu His Arg Leu Glu Asp Ala 
    770                 775                 780                 


Glu Thr Glu Ser Gln Ser Ala Val Ser Glu Thr Pro Gln Lys Arg Ser 
785                 790                 795                 800 


Asp Ala Val Gln Lys Glu Val Val Asp Met Lys Ser Glu Gly Gln Ala 
                805                 810                 815     


Thr Val Ile Gln Gln Leu Glu Gln Thr Ile Glu Asp Leu Arg Thr Lys 
            820                 825                 830         


Ile Ala Glu Leu Glu Arg Gln Tyr Pro Ala Leu Asp Thr Glu Val Ala 
        835                 840                 845             


Ser Gly His Gln Gly Leu Glu Asn Gly Val Thr Ala Ser Gly Asp Val 
    850                 855                 860                 


Cys Leu Glu Ala Leu Arg Leu Glu Glu Lys Glu Val Arg His His Arg 
865                 870                 875                 880 


Ile Leu Glu Ala Lys Ser Ile Gln Thr Ser Pro Thr Glu Glu Gly Gly 
                885                 890                 895     


Val Leu Thr Leu Pro Pro Val Asp Gly Leu Pro Gly Arg Pro Pro Cys 
            900                 905                 910         


Pro Pro Gly Ala Glu Ser Gly Pro Gln Thr Lys Phe Cys Ser Glu Ile 
        915                 920                 925             


Ser Leu Ile Val Ser Pro Arg Arg Ile Ser Val Gln Leu Asp Ser His 
    930                 935                 940                 


Gln Pro Thr Gln Ser Ile Ser Gln Pro Pro Pro Pro Pro Ser Leu Leu 
945                 950                 955                 960 


Trp Ser Ala Gly Gln Gly Gln Pro Gly Ser Gln Pro Pro His Ser Ile 
                965                 970                 975     


Ser Thr Glu Phe Gln Thr Ser His Glu His Ser Val Ser Ser Ala Phe 
            980                 985                 990         


Lys Asn Ser Cys Asn Ile Pro Ser  Pro Pro Pro Leu Pro  Cys Thr Glu 
        995                 1000                 1005             


Ser Ser  Ser Ser Met Pro Gly  Leu Gly Met Val Pro  Pro Pro Pro 
    1010                 1015                 1020             


Pro Pro  Leu Pro Gly Met Thr  Val Pro Thr Leu Pro  Ser Thr Ala 
    1025                 1030                 1035             


Ile Pro  Gln Pro Pro Pro Leu  Gln Gly Thr Glu Met  Leu Pro Pro 
    1040                 1045                 1050             


Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile Pro Pro  Pro Pro Pro 
    1055                 1060                 1065             


Leu Pro  Gly Ala Gly Ile Leu  Pro Leu Pro Pro Leu  Pro Gly Ala 
    1070                 1075                 1080             


Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly Ala Ala  Ile Pro Pro 
    1085                 1090                 1095             


Pro Pro  Pro Leu Pro Gly Ala  Gly Ile Pro Leu Pro  Pro Pro Leu 
    1100                 1105                 1110             


Pro Gly  Ala Gly Ile Pro Pro  Pro Pro Pro Leu Pro  Gly Ala Gly 
    1115                 1120                 1125             


Ile Pro  Pro Pro Pro Pro Leu  Pro Gly Ala Gly Ile  Pro Pro Pro 
    1130                 1135                 1140             


Pro Pro  Leu Pro Gly Ala Gly  Ile Pro Pro Pro Pro  Pro Leu Pro 
    1145                 1150                 1155             


Gly Ala  Gly Ile Pro Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile 
    1160                 1165                 1170             


Pro Pro  Pro Pro Pro Leu Pro  Gly Ala Gly Ile Pro  Pro Pro Pro 
    1175                 1180                 1185             


Pro Leu  Pro Gly Ala Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly 
    1190                 1195                 1200             


Ala Gly  Ile Pro Pro Pro Pro  Pro Leu Pro Gly Ala  Gly Ile Pro 
    1205                 1210                 1215             


Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile Pro Pro  Pro Pro Pro 
    1220                 1225                 1230             


Leu Pro  Gly Ala Gly Ile Pro  Pro Pro Pro Pro Leu  Pro Gly Val 
    1235                 1240                 1245             


Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly Ala Gly  Ile Pro Pro 
    1250                 1255                 1260             


Pro Pro  Pro Leu Pro Gly Ala  Gly Ile Pro Pro Pro  Pro Pro Leu 
    1265                 1270                 1275             


Pro Gly  Ala Gly Ile Pro Pro  Pro Pro Pro Leu Pro  Arg Val Gly 
    1280                 1285                 1290             


Ile Pro  Pro Pro Pro Pro Leu  Pro Gly Ala Gly Ile  Pro Pro Pro 
    1295                 1300                 1305             


Pro Pro  Leu Pro Gly Ala Gly  Ile Pro Pro Pro Pro  Pro Leu Pro 
    1310                 1315                 1320             


Gly Val  Gly Ile Pro Pro Pro  Pro Pro Leu Pro Gly  Val Gly Ile 
    1325                 1330                 1335             


Pro Pro  Pro Pro Pro Leu Pro  Gly Ala Gly Ile Pro  Pro Pro Pro 
    1340                 1345                 1350             


Pro Leu  Pro Gly Met Gly Ile  Pro Pro Ala Pro Ala  Pro Pro Leu 
    1355                 1360                 1365             


Pro Pro  Pro Gly Thr Gly Ile  Pro Pro Pro Pro Leu  Leu Pro Val 
    1370                 1375                 1380             


Ser Gly  Pro Pro Leu Leu Pro  Gln Val Gly Ser Ser  Thr Leu Pro 
    1385                 1390                 1395             


Thr Pro  Gln Val Cys Gly Phe  Leu Pro Pro Pro Leu  Pro Ser Gly 
    1400                 1405                 1410             


Leu Phe  Gly Leu Gly Met Asn  Gln Asp Lys Gly Ser  Arg Lys Gln 
    1415                 1420                 1425             


Pro Ile  Glu Pro Cys Arg Pro  Met Lys Pro Leu Tyr  Trp Thr Arg 
    1430                 1435                 1440             


Ile Gln  Leu His Ser Lys Arg  Asp Ser Ser Thr Ser  Leu Ile Trp 
    1445                 1450                 1455             


Glu Lys  Ile Glu Glu Pro Ser  Ile Asp Cys His Glu  Phe Glu Glu 
    1460                 1465                 1470             


Leu Phe  Ser Lys Thr Ala Val  Lys Glu Arg Lys Lys  Pro Ile Ser 
    1475                 1480                 1485             


Asp Thr  Ile Ser Lys Thr Lys  Ala Lys Gln Val Val  Lys Leu Leu 
    1490                 1495                 1500             


Ser Asn  Lys Arg Ser Gln Ala  Val Gly Ile Leu Met  Ser Ser Leu 
    1505                 1510                 1515             


His Leu  Asp Met Lys Asp Ile  Gln His Ala Val Val  Asn Leu Asp 
    1520                 1525                 1530             


Asn Ser  Val Val Asp Leu Glu  Thr Leu Gln Ala Leu  Tyr Glu Asn 
    1535                 1540                 1545             


Arg Ala  Gln Ser Asp Glu Leu  Glu Lys Ile Glu Lys  His Gly Arg 
    1550                 1555                 1560             


Ser Ser  Lys Asp Lys Glu Asn  Ala Lys Ser Leu Asp  Lys Pro Glu 
    1565                 1570                 1575             


Gln Phe  Leu Tyr Glu Leu Ser  Leu Ile Pro Asn Phe  Ser Glu Arg 
    1580                 1585                 1590             


Val Phe  Cys Ile Leu Phe Gln  Ser Thr Phe Ser Glu  Ser Ile Cys 
    1595                 1600                 1605             


Ser Ile  Arg Arg Lys Leu Glu  Leu Leu Gln Lys Leu  Cys Glu Thr 
    1610                 1615                 1620             


Leu Lys  Asn Gly Pro Gly Val  Met Gln Val Leu Gly  Leu Val Leu 
    1625                 1630                 1635             


Ala Phe  Gly Asn Tyr Met Asn  Gly Gly Asn Lys Thr  Arg Gly Gln 
    1640                 1645                 1650             


Ala Asp  Gly Phe Gly Leu Asp  Ile Leu Pro Lys Leu  Lys Asp Val 
    1655                 1660                 1665             


Lys Ser  Ser Asp Asn Ser Arg  Ser Leu Leu Ser Tyr  Ile Val Ser 
    1670                 1675                 1680             


Tyr Tyr  Leu Arg Asn Phe Asp  Glu Asp Ala Gly Lys  Glu Gln Cys 
    1685                 1690                 1695             


Leu Phe  Pro Leu Pro Glu Pro  Gln Asp Leu Phe Gln  Ala Ser Gln 
    1700                 1705                 1710             


Met Lys  Phe Glu Asp Phe Gln  Lys Asp Leu Arg Lys  Leu Lys Lys 
    1715                 1720                 1725             


Asp Leu  Lys Ala Cys Glu Val  Glu Ala Gly Lys Val  Tyr Gln Val 
    1730                 1735                 1740             


Ser Ser  Lys Glu His Met Gln  Pro Phe Lys Glu Asn  Met Glu Gln 
    1745                 1750                 1755             


Phe Ile  Ile Gln Ala Lys Ile  Asp Gln Glu Ala Glu  Glu Asn Ser 
    1760                 1765                 1770             


Leu Thr  Glu Thr His Lys Cys  Phe Leu Glu Thr Thr  Ala Tyr Phe 
    1775                 1780                 1785             


Phe Met  Lys Pro Lys Leu Gly  Glu Lys Glu Val Ser  Pro Asn Ala 
    1790                 1795                 1800             


Phe Phe  Ser Ile Trp His Glu  Phe Ser Ser Asp Phe  Lys Asp Phe 
    1805                 1810                 1815             


Trp Lys  Lys Glu Asn Lys Leu  Leu Leu Gln Glu Arg  Val Lys Glu 
    1820                 1825                 1830             


Ala Glu  Glu Val Cys Arg Gln  Lys Lys Gly Lys Ser  Leu Tyr Lys 
    1835                 1840                 1845             


Ile Lys  Pro Arg His Asp Ser  Gly Ile Lys Ala Lys  Ile Ser Met 
    1850                 1855                 1860             


Lys Thr  
    1865 


<210>  457
<211>  4199
<212>  DNA
<213>  Homosapiens

<400>  457
aggattcaga gctaagtctc cgggctcctt tcacatctgc aggagcagcc agcctgggac     60

cgcgcggcgc ggggcgcgct ctcgcctctc ctgcaccctc agccggcgcg cttctcttat    120

gggcgtctgc tgcagtctgg ctgcggtcga actgaaagcg gcggcgggag accaaactta    180

gaccccgctg tggactagag aactcagaga aggcagaggg agagggagag agagagagag    240

aagggacccg aggaggaggc ttccatcacg tcattgcagg atgttctgga agctttccct    300

gtccttgttc ctggtggcgg tgctggtgaa ggtggcggaa gcccggaaga accggccggc    360

gggcgccatc ccctcgcctt acaaggacgg cagcagcaac aactcggaga gatggcagca    420

ccagatcaag gaggtgctgg cctccagcca ggaggccctg gtggtcaccg agcgcaagta    480

cctcaagagt gactggtgca agacgcagcc gctgcggcag acggtgagcg aggagggctg    540

ccggagccgc accatcctca accgcttctg ctacggccag tgcaactcct tctacatccc    600

gcggcacgtg aagaaggagg aggagtcctt ccagtcctgc gccttctgca agccccagcg    660

cgtcacctcc gtcctcgtgg agctcgagtg ccccggcctg gacccaccct tccgactcaa    720

gaaaatccag aaggtgaagc agtgccggtg catgtccgtg aacctgagcg actcggacaa    780

gcagtgagcg ccgggccgga cgcagctcag ccccgcgcgc gcccggccgc tgggtggcgc    840

cgccgccgcc tctgtccctg ccctccgagc ccactgtcac gctgcctggt gttccccctc    900

agcagcaagc acttctctta gggctgacgg tgtccttgtc acagacgtgg atcgcaagtg    960

gagcttttgc tgatgtgttc ctgaccgacc ccgggtccca cctgtgcccc ctaaaccagg   1020

cggtggatca ggcccgaagg aaaatgctgg aaaaccacca ccgccaccca gcagtcagag   1080

aggacctttc gaggtgatgc actgtaaatc cggcattgat gtttccacca tgtggaaaag   1140

caaggatttc cctggccccg ccctgcactc cagctcgccc ctttcccgcg cgaagtgaag   1200

gatgcgtcac ttttctgagc ggcccctcag acctctcctg ctggtccctg gacctctggc   1260

tgggagcgct cattcttgtg actggcaggc tgccctcggt cgctgctgtg atgaggatat   1320

gtgcaacctc cataaatatg tcggtggacg gggcgtctcc taataaacct gataccaaga   1380

agacaacttg agccacttgg atcccgaagt gggcttcccg ggaaacctcg agcagagcag   1440

gctacacaat cccccatcct caagtcccca ccgcctcttc ttcctcactg tccccgcccc   1500

ctatttgtgg actaaagatg aactctggtg tgcatgctat tattgctgca attagaatat   1560

tatcacacac aaaggtctct atattaacgc tggttttata agtgaccgta tattgtaaag   1620

agctgttaaa aagtattata gacctattca tgtattattt cacatgtttt gactctggct   1680

tgcagcacca ttcggagtaa ggatgacagc aggcccagaa ggtgtcttac tcagaaaaaa   1740

aaatgcctgg tcagcaattc actgtcatgc acctattttt agattgggca gggagatggg   1800

aggagtcgtg atttttactt tgaatactat ttcactgacg ttactaagca ttgcagcaca   1860

atgtagaaat tggcttggga tggataggta tagggaaggg cattcgttgg gaaattgatg   1920

accggaaact agaaagcccc tataatgtgg aatatgcata tgtggggtga aaccgtatac   1980

tactttcact gccatgacac taggcaaaaa atatttcctg ttaaaagaaa gagaaaaaga   2040

gagggatatt gaaaaatata aggagttgag tcgctttgtg gtatagaagg gagtaaggaa   2100

taaaagatat agaatagtaa tctagttgaa ctgttctgca caaaacatgc ttccttttca   2160

aagaatagac ttcaaaaggg acgaacaaac attaggtcac cttttgtgtt tataatgaat   2220

tgttgacgtt tccatgctgt ggtctcttga tatacggaag tagacgtaac ttattttcca   2280

gcgaaattat atacttcttc tgggctcctt tgctcagttg ccccaggaag gcttccctgt   2340

gagtaatgct tatggaatct gacaaatgtg aatgagctgc cattggtggg aatcagtaaa   2400

ctttgaaaac ctttcactga tgattccctg gtaagtgctc ctgtgagggg ccacttccct   2460

agtatgtgag agagaccctc tgcaagccgc tgtggggact tagcttcctg atactaggta   2520

gtgatggtgg atctagagac attcacttga agagcaagga ttggggtggg gtgggttggt   2580

gaatctatct caggccactg cactgcaagg tgcatttctg tcatttctgc aacaccatga   2640

gacctgagca agaatgtgct gtggcagagg gggtcttggt ttcataaatg ggtatataca   2700

gcctgaactc aggaggcaga aatcaaaaga aatccttgag ggctggaacc tgaggataga   2760

gcgaaaatgg agagaagggt gttcaaggtc aggagtgatt tttgcatttg gtggaaaacc   2820

tcaagtcaga ctcagtggca gaacatgcag cagaaaagct gtgaaggaag gaaatttacg   2880

tgattgtaat ggaggctagg ggtggattgg gaggtgagtg gaggagagtc tctgaccagc   2940

tgcagagcca acccctatca ttttattaac atggaaccca cacagatagg ggagggatta   3000

agctaagaac ttacagaatg caaacacgag cacactctct tcgaacccaa ttgtgggtgt   3060

agcaatgaaa gcaatatgat atgctgcagt gtgaagctcc ttctggggtt atcgtatgta   3120

caaagtttac cttataatgg ctcaaattgt atttaatttt tttgttttgt ttataaatga   3180

agaaaagcta taagtataat gtaattattt tataggtata ctattaaatt atagaacaaa   3240

taaagataat ctaggattat atgtgatccc ggtgtgacgt gccataaaag tggaattttt   3300

gacttgttgc agtgagctgt gaagcagcac tatgcgttca gagagttttt gttcaaccat   3360

ggtgagttca acctctagct tatgtcacat gatctccttt ggggtctgga atcttctaag   3420

agaaatagaa tcaggcatcc aaggagcaga agtgatggag gtggccctca atcctggtct   3480

ttggaagctt ccaagcctct tccacatccc ctgccagctg aagacagagt attctcactg   3540

tgctggctga aggagaaaca ctaaacaagg aaaccttgag aaactgcagc aatggaagtc   3600

cactgttagt ctctccgtta gcaccaggga cacacttgtt ctgagttttg ttcattttca   3660

catttactcc tcatgagttc caacatttct taatttaaat atttcttagt ttatagcatc   3720

tccatttttc tattaattga cttaatctgc catttaagaa aactccgtaa tcaataaaaa   3780

ataaaatcca caatcaaact gcacatggtt gatccactgt gtaggcttca aaggaattaa   3840

actcaacttc ctaggaaata attcatctta gtttattaaa tgggacagaa tatttcactg   3900

ctaacgtatt ctaactcact tgtttttgaa attggccaga tgatttttaa gttataaagt   3960

caatgaaaat gacttttgct attgtgtgaa caacttagaa tgtatatatt cccagaaggc   4020

ttatttaatg attgacctat caccactgat tattaatgtc tgcatgaatg ataacaataa   4080

gaccaagtca tcaataatgc aatgaaaatt ttttaagtga aagcaagttt attaagaaag   4140

taaaggaata aagaatgcct acttcatagg cagagcagcc taaaaaaaaa aaaaaaaaa    4199


<210>  458
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  458

Met Phe Trp Lys Leu Ser Leu Ser Leu Phe Leu Val Ala Val Leu Val 
1               5                   10                  15      


Lys Val Ala Glu Ala Arg Lys Asn Arg Pro Ala Gly Ala Ile Pro Ser 
            20                  25                  30          


Pro Tyr Lys Asp Gly Ser Ser Asn Asn Ser Glu Arg Trp Gln His Gln 
        35                  40                  45              


Ile Lys Glu Val Leu Ala Ser Ser Gln Glu Ala Leu Val Val Thr Glu 
    50                  55                  60                  


Arg Lys Tyr Leu Lys Ser Asp Trp Cys Lys Thr Gln Pro Leu Arg Gln 
65                  70                  75                  80  


Thr Val Ser Glu Glu Gly Cys Arg Ser Arg Thr Ile Leu Asn Arg Phe 
                85                  90                  95      


Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro Arg His Val Lys Lys 
            100                 105                 110         


Glu Glu Glu Ser Phe Gln Ser Cys Ala Phe Cys Lys Pro Gln Arg Val 
        115                 120                 125             


Thr Ser Val Leu Val Glu Leu Glu Cys Pro Gly Leu Asp Pro Pro Phe 
    130                 135                 140                 


Arg Leu Lys Lys Ile Gln Lys Val Lys Gln Cys Arg Cys Met Ser Val 
145                 150                 155                 160 


Asn Leu Ser Asp Ser Asp Lys Gln 
                165             


<210>  459
<211>  1913
<212>  DNA
<213>  Homosapiens

<400>  459
ccggaggacg cgctgctgcg agaccagccg cggcgtcttt ggcagtggtg ggcgtgcttg     60

cgggtccagg agggcccctc tcccgcgacc gccgaccacg atgagagcgt gaagaccctc    120

tcgaaaggaa gggctctgct ctacacactg gtgtctcctg cggaagggca gctgggcacg    180

ccttccagac cgagcaaaag ttgaaaaatc agtaacccaa gatgactaac caaatcaata    240

tgctgggcag gatgagacat cagtgtctgc ctcagacaga agagcacaca caaaacatga    300

cctctcactc caagcccagt tacagcagaa agttttcatg gagaaatgga atcacacttc    360

aaatgatttc attttgttgg gtctgcttcc cccaaatcaa actggaatat ttctcttgtg    420

ccttatcatc ctcatattct ttctggcctc ggtgggtaac tcggccatga ttcacctcat    480

ccacgtggat cctcgtctcc acacaccgat gtactttctt ctcagccagc tctcccttat    540

ggacctgatg tacatctcca ccaccgtccc caagatggcg tacaacttcc tgtccggcca    600

gaaaggcatc tccttcctgg gatgtggtgt gcaaagcttc ttcttcctga ccatggcgtg    660

ttctgaaggc ttactcctga cctccatggc ctacgaccgt tatttggcca tctgccactc    720

tctctattat cctatccgca tgagtaaaat gatgtgtgtg aagatgattg gaggctcttg    780

gacactgggg tccatcaact ccttggcaca cacagtcttt gcccttcata ttccctactg    840

caggtctagg gctattgacc atttcttctg cgatgtccca gccatgttgc ttcttgcctg    900

tacagatact tgggtctatg aatatatggt ttttgtaagt acaagcctct ttctcctttt    960

ccctttcatt ggcatcactt cttcctgtgg ccgagtccta tttgctgtct atcatatgca   1020

ctcaaaggag gggagaaaaa aggccttcac caccatttca acacatttaa ctgtagtgat   1080

cttttactat gcaccttttg tctacaccta tcttcggccc aggaatctcc gctcaccagc   1140

tgaagacaag atcctggcag tcttctacac catccttacc cccatgctca atcccattat   1200

ctacagcctg aggaataagg aagtcctggg ggctatgagg agagtgtttg ggatattctc   1260

tttcctgaaa gaataatcat ggccatcccc actccctttg tatttcctct ttccaagttg   1320

attccaacac gctagagcag ggttgtccaa tagaaataca acataattta aaattttcta   1380

ataggtacat ttaagcagtc aaataaattt aaataatata tttaattcaa aacaatgtta   1440

taattaatat taatattaac aatattgatg ttaattacat agcatactat ttcaataaat   1500

tatatgcaat atattatagt acatgtttgt acatatatta ctattaacgt gataatgttt   1560

attcttgtat attgacatag aatttcttca tgtaataaca caaatttgtt aatgttgcct   1620

tttactctgt ttgcattcta agtcttcaaa gtcttgtgtt tgttttatag agtgcagtgc   1680

agcttggaca aaacacattt caagtgccca gtagtcagtg tctatagtgt tggacagcac   1740

attcttagag catccccaat caatagtttc agaagttata tatgcatgtg tatgtgcatg   1800

tatggtgtat acaaacatat ttttgttata tacaatattg ctgatgaact gaaaattaac   1860

aagtaaaatg cacatgctaa ggtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa          1913


<210>  460
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  460

Met Glu Lys Trp Asn His Thr Ser Asn Asp Phe Ile Leu Leu Gly Leu 
1               5                   10                  15      


Leu Pro Pro Asn Gln Thr Gly Ile Phe Leu Leu Cys Leu Ile Ile Leu 
            20                  25                  30          


Ile Phe Phe Leu Ala Ser Val Gly Asn Ser Ala Met Ile His Leu Ile 
        35                  40                  45              


His Val Asp Pro Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 
    50                  55                  60                  


Leu Ser Leu Met Asp Leu Met Tyr Ile Ser Thr Thr Val Pro Lys Met 
65                  70                  75                  80  


Ala Tyr Asn Phe Leu Ser Gly Gln Lys Gly Ile Ser Phe Leu Gly Cys 
                85                  90                  95      


Gly Val Gln Ser Phe Phe Phe Leu Thr Met Ala Cys Ser Glu Gly Leu 
            100                 105                 110         


Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys His Ser 
        115                 120                 125             


Leu Tyr Tyr Pro Ile Arg Met Ser Lys Met Met Cys Val Lys Met Ile 
    130                 135                 140                 


Gly Gly Ser Trp Thr Leu Gly Ser Ile Asn Ser Leu Ala His Thr Val 
145                 150                 155                 160 


Phe Ala Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asp His Phe 
                165                 170                 175     


Phe Cys Asp Val Pro Ala Met Leu Leu Leu Ala Cys Thr Asp Thr Trp 
            180                 185                 190         


Val Tyr Glu Tyr Met Val Phe Val Ser Thr Ser Leu Phe Leu Leu Phe 
        195                 200                 205             


Pro Phe Ile Gly Ile Thr Ser Ser Cys Gly Arg Val Leu Phe Ala Val 
    210                 215                 220                 


Tyr His Met His Ser Lys Glu Gly Arg Lys Lys Ala Phe Thr Thr Ile 
225                 230                 235                 240 


Ser Thr His Leu Thr Val Val Ile Phe Tyr Tyr Ala Pro Phe Val Tyr 
                245                 250                 255     


Thr Tyr Leu Arg Pro Arg Asn Leu Arg Ser Pro Ala Glu Asp Lys Ile 
            260                 265                 270         


Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Leu Gly Ala Met Arg Arg Val Phe 
    290                 295                 300                 


Gly Ile Phe Ser Phe Leu Lys Glu 
305                 310         


<210>  461
<211>  1008
<212>  DNA
<213>  Homosapiens

<400>  461
atgaacattt cagatgtcat ctcctttgat attttggttt cagccatgaa aacaggaaat     60

caaagttttg ggacagattt tctacttgtt ggtcttttcc aatatggctg gataaactct    120

cttctctttg tcgtcattgc caccctcttt acagttgctc tgacaggaaa tatcatgctg    180

atccacctca ttcgactgaa caccagactc cacactccaa tgtactttct gctcagtcag    240

ctctccatcg ttgacctcat gtacatctcc accacagtgc ccaagatggc agtcagcttc    300

ctctcacaga gtaagaccat tagatttttg ggctgtgaga ttcaaacgta tgtgttcttg    360

gcccttggtg gaactgaagc ccttctcctt ggttttatgt cttatgatcg ctatgtagct    420

atctgtcacc ctttacatta tcctatgctt atgagcaaga agatctgctg cctcatggtt    480

gcatgtgcat gggccagtgg ttctatcaat gctttcatac atacattgta tgtgtttcag    540

cttccattct gtaggtctcg gctcattaac cactttttct gtgaagttcc agctctacta    600

tcattggtgt gtcaggacac ctcccagtat gagtatacag tcctcctgag tggacttatt    660

atcttgctac taccattcct agccattctg gcttcctatg ctcgtgtgct tattgtggta    720

ttccagatga gctcaggaaa aggacaggca aaagctgttt ccacttgttc ctcccacctg    780

attgtggcaa gcctgttcta tgcaaccact ctctttacct acacaaggcc acactccttg    840

cgttcccctt cacgggataa ggcggtggca gtattttaca ccattgtcac acctctactg    900

aacccattta tctacagcct gagaaataag gaagtgacgg gggcagtgag gagactgttg    960

ggatattgga tatgctgtag aaaatatgac ttcagatctc tgtattga                1008


<210>  462
<211>  335
<212>  PRT
<213>  Homosapiens

<400>  462

Met Asn Ile Ser Asp Val Ile Ser Phe Asp Ile Leu Val Ser Ala Met 
1               5                   10                  15      


Lys Thr Gly Asn Gln Ser Phe Gly Thr Asp Phe Leu Leu Val Gly Leu 
            20                  25                  30          


Phe Gln Tyr Gly Trp Ile Asn Ser Leu Leu Phe Val Val Ile Ala Thr 
        35                  40                  45              


Leu Phe Thr Val Ala Leu Thr Gly Asn Ile Met Leu Ile His Leu Ile 
    50                  55                  60                  


Arg Leu Asn Thr Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 
65                  70                  75                  80  


Leu Ser Ile Val Asp Leu Met Tyr Ile Ser Thr Thr Val Pro Lys Met 
                85                  90                  95      


Ala Val Ser Phe Leu Ser Gln Ser Lys Thr Ile Arg Phe Leu Gly Cys 
            100                 105                 110         


Glu Ile Gln Thr Tyr Val Phe Leu Ala Leu Gly Gly Thr Glu Ala Leu 
        115                 120                 125             


Leu Leu Gly Phe Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 
    130                 135                 140                 


Leu His Tyr Pro Met Leu Met Ser Lys Lys Ile Cys Cys Leu Met Val 
145                 150                 155                 160 


Ala Cys Ala Trp Ala Ser Gly Ser Ile Asn Ala Phe Ile His Thr Leu 
                165                 170                 175     


Tyr Val Phe Gln Leu Pro Phe Cys Arg Ser Arg Leu Ile Asn His Phe 
            180                 185                 190         


Phe Cys Glu Val Pro Ala Leu Leu Ser Leu Val Cys Gln Asp Thr Ser 
        195                 200                 205             


Gln Tyr Glu Tyr Thr Val Leu Leu Ser Gly Leu Ile Ile Leu Leu Leu 
    210                 215                 220                 


Pro Phe Leu Ala Ile Leu Ala Ser Tyr Ala Arg Val Leu Ile Val Val 
225                 230                 235                 240 


Phe Gln Met Ser Ser Gly Lys Gly Gln Ala Lys Ala Val Ser Thr Cys 
                245                 250                 255     


Ser Ser His Leu Ile Val Ala Ser Leu Phe Tyr Ala Thr Thr Leu Phe 
            260                 265                 270         


Thr Tyr Thr Arg Pro His Ser Leu Arg Ser Pro Ser Arg Asp Lys Ala 
        275                 280                 285             


Val Ala Val Phe Tyr Thr Ile Val Thr Pro Leu Leu Asn Pro Phe Ile 
    290                 295                 300                 


Tyr Ser Leu Arg Asn Lys Glu Val Thr Gly Ala Val Arg Arg Leu Leu 
305                 310                 315                 320 


Gly Tyr Trp Ile Cys Cys Arg Lys Tyr Asp Phe Arg Ser Leu Tyr 
                325                 330                 335 


<210>  463
<211>  925
<212>  DNA
<213>  Homosapiens

<400>  463
atggaaaatt acaatcaaac atcaactgct ttcatcttgt tgggattgtc gccaccacca     60

aaaattggcc atttcatctt cattctcatt aatttcgttt tcctaatggc tctaattgga    120

aacctatcca tgattcttct catcttcttg gacatccatc tccacacacc catgtatttc    180

ctacttagtc agctctccct cattgaccta aattatattt ccaccattgt tcctaagatg    240

gtttatgatt tttctgtatg gaaacaagtc tatctccttc actgggtgtg ggattcagag    300

tttcttcttc ctgactttag caggtgcaga agcgctgctc ctgacatcaa tggcctatga    360

tcgttatgtg gctatttgct ttcctctcca ctatcccatc cgtatgagaa aaagagtgtg    420

tgcactgatg ataacaggat cttggatgat aggctccatc aactcttgtg ctcacacggt    480

atatgcactc cgtatcccat attgcaagtc cagagccatc aatcattttt tctgtgatgt    540

tccagctatg ttgaccctag cctgcacgga tacctgggtc tatgagtgca cggtgttttt    600

gagcaccacc atttttcttg tgtttccctt catttgtatt gcatgttcct atggccggat    660

tctccttgct gtctaccaca tgcactctgc agaagggagg aagaaggcct attcgacctg    720

cagcacccac ctcactgtag tgactttcta ctatgcaccc tttgcttata cctatctacg    780

cccaagatcc ctgcgatctc cgacagagga caaggttctg gctgtcttct acaccatcct    840

cactccaatg ctcaacccca tcatctacag cctgagaaac aaggaggtga tgggggccct    900

gacacgagtg attcagaaaa tcttt                                          925


<210>  464
<211>  1134
<212>  DNA
<213>  Homosapiens

<400>  464
tgggagtctt gtaatgcagc cactgtggat aaaagtgaat tactgttctt aatttaccct     60

tttgtctccc ttcaggatgg attgtaggaa ttccccatgg aaaattacaa tcaaacatca    120

actgatttca tcttattggg gctgttccca caatcaagaa ttggcctttt cgtattcacc    180

ctcatttttc tcattttcct aatggctcta attggaaatc tatccatgat tcttctcatc    240

tttttggaca tccatctcca cacacctatg tatttcctac ttagtcagct ctccctcatt    300

gacctaaatt acatctccac cattgttcca aagatggttt atgattttct gtatggaaac    360

aagtctatct ccttcactgg atgtgggatt cagagtttct tcttcttgac tttagcagtt    420

gcagaagggc tgctcctgac atcaatggcc tatgatcgtt atgtggccat ttgctttcct    480

ctccactatc ccatccgtat aagcaaaaga gtgtgtgtga tgatgataac aggatcttgg    540

atgataagct ctatcaactc ttgtgctcac acagtatatg cactctgtat cccatattgc    600

aagtccagag ccatcaatca ttttttctgt gatgttccag ctatgttgac gctagcctgc    660

acagacactt gggtctatga gagcacagtg tttttgagca gcaccatctt tcttgtgctt    720

cctttcactg gtattgcatg ttcctatggc cgggttctcc ttgctgtcta ccgcatgcac    780

tctgcagaag ggaggaagaa ggcctattca acctgtagca cccacctcac tgtagtgtcc    840

ttctactatg caccctttgc ttatacctat gtacgtccaa gatccctgcg atctccaaca    900

gaggacaaga ttctggctgt tttctacacc atcctcaccc caatgctcaa ccccatcatc    960

tacagcctga gaaacaagga ggtgatgggg gccctgacac aagtgattca gaaaatcttc   1020

tcagtgaaaa tgtagacata cgttctgtgt tagagtcaaa gcgctaggtt catatcaact   1080

tagtagtgta cagcagtgaa gaaaaacatt attacatgcc cagtgtgtca aaca         1134


<210>  465
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  465

Met Glu Asn Tyr Asn Gln Thr Ser Thr Asp Phe Ile Leu Leu Gly Leu 
1               5                   10                  15      


Phe Pro Gln Ser Arg Ile Gly Leu Phe Val Phe Thr Leu Ile Phe Leu 
            20                  25                  30          


Ile Phe Leu Met Ala Leu Ile Gly Asn Leu Ser Met Ile Leu Leu Ile 
        35                  40                  45              


Phe Leu Asp Ile His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 
    50                  55                  60                  


Leu Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met 
65                  70                  75                  80  


Val Tyr Asp Phe Leu Tyr Gly Asn Lys Ser Ile Ser Phe Thr Gly Cys 
                85                  90                  95      


Gly Ile Gln Ser Phe Phe Phe Leu Thr Leu Ala Val Ala Glu Gly Leu 
            100                 105                 110         


Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro 
        115                 120                 125             


Leu His Tyr Pro Ile Arg Ile Ser Lys Arg Val Cys Val Met Met Ile 
    130                 135                 140                 


Thr Gly Ser Trp Met Ile Ser Ser Ile Asn Ser Cys Ala His Thr Val 
145                 150                 155                 160 


Tyr Ala Leu Cys Ile Pro Tyr Cys Lys Ser Arg Ala Ile Asn His Phe 
                165                 170                 175     


Phe Cys Asp Val Pro Ala Met Leu Thr Leu Ala Cys Thr Asp Thr Trp 
            180                 185                 190         


Val Tyr Glu Ser Thr Val Phe Leu Ser Ser Thr Ile Phe Leu Val Leu 
        195                 200                 205             


Pro Phe Thr Gly Ile Ala Cys Ser Tyr Gly Arg Val Leu Leu Ala Val 
    210                 215                 220                 


Tyr Arg Met His Ser Ala Glu Gly Arg Lys Lys Ala Tyr Ser Thr Cys 
225                 230                 235                 240 


Ser Thr His Leu Thr Val Val Ser Phe Tyr Tyr Ala Pro Phe Ala Tyr 
                245                 250                 255     


Thr Tyr Val Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Ile 
            260                 265                 270         


Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Thr Gln Val Ile 
    290                 295                 300                 


Gln Lys Ile Phe Ser Val Lys Met 
305                 310         


<210>  466
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  466
atggaaaatt acaatcaaac atcaactgat ttcatcttat taggattctt cccaccatca     60

agaattggcc ttttcctctt catcctcatt gttttcattt tcctaatggc tctaattgga    120

aacctatcca tgattcttct catcttcttg gacacccatc tccacacacc catgtatttc    180

ctacttagtc agctctccct cattgaccta aattacatct ccaccattgt tcctaagatg    240

gcatctgatt ttctgtctgg taacaagtct atctccttca ctgggtgtgg gattcagagt    300

ttcttcttct cggcattagg aggtgcagaa gcactacttt tggcatctat ggcctatgat    360

cgttacattg ctatttgctt tcctcttcac tatcccatcc gcatgagcaa aagaatgtgt    420

gtgctgatga taacagggtc ttggatcata ggctcgatca atgcttgtgc tcacactgta    480

tatgtactcc atattcctta ttgccaatcc agggccatca atcatttctt ctgtgatgtc    540

ccagcaatgg tgactctggc ctgcatggac acctgggtct atgagggcac agtgtttttg    600

agcaccacca tctttctcgt gtttcccttc attgctattt catgttccta tggccgggtt    660

ctccttgctg tctaccacat gaaatctgca gaagggagga agaaagccta cctgacctgc    720

agcacccacc tcactgtagt aactttctac tatgcacctt ttgtctacac ttatctacgt    780

ccaagatccc tgcgatctcc aacagaggac aaggttctgg ctgtcttcta caccaccctc    840

actccaatgc tcaaccccat catctatagc ctgaggaaca aggaggtgat gggggccctg    900

acacgagtga gtcagagaat ctgctctggg aaaatgtag                           939


<210>  467
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  467

Met Glu Asn Tyr Asn Gln Thr Ser Thr Asp Phe Ile Leu Leu Gly Phe 
1               5                   10                  15      


Phe Pro Pro Ser Arg Ile Gly Leu Phe Leu Phe Ile Leu Ile Val Phe 
            20                  25                  30          


Ile Phe Leu Met Ala Leu Ile Gly Asn Leu Ser Met Ile Leu Leu Ile 
        35                  40                  45              


Phe Leu Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 
    50                  55                  60                  


Leu Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met 
65                  70                  75                  80  


Ala Ser Asp Phe Leu Ser Gly Asn Lys Ser Ile Ser Phe Thr Gly Cys 
                85                  90                  95      


Gly Ile Gln Ser Phe Phe Phe Ser Ala Leu Gly Gly Ala Glu Ala Leu 
            100                 105                 110         


Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Phe Pro 
        115                 120                 125             


Leu His Tyr Pro Ile Arg Met Ser Lys Arg Met Cys Val Leu Met Ile 
    130                 135                 140                 


Thr Gly Ser Trp Ile Ile Gly Ser Ile Asn Ala Cys Ala His Thr Val 
145                 150                 155                 160 


Tyr Val Leu His Ile Pro Tyr Cys Gln Ser Arg Ala Ile Asn His Phe 
                165                 170                 175     


Phe Cys Asp Val Pro Ala Met Val Thr Leu Ala Cys Met Asp Thr Trp 
            180                 185                 190         


Val Tyr Glu Gly Thr Val Phe Leu Ser Thr Thr Ile Phe Leu Val Phe 
        195                 200                 205             


Pro Phe Ile Ala Ile Ser Cys Ser Tyr Gly Arg Val Leu Leu Ala Val 
    210                 215                 220                 


Tyr His Met Lys Ser Ala Glu Gly Arg Lys Lys Ala Tyr Leu Thr Cys 
225                 230                 235                 240 


Ser Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Val Tyr 
                245                 250                 255     


Thr Tyr Leu Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Val 
            260                 265                 270         


Leu Ala Val Phe Tyr Thr Thr Leu Thr Pro Met Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Thr Arg Val Ser 
    290                 295                 300                 


Gln Arg Ile Cys Ser Gly Lys Met 
305                 310         


<210>  468
<211>  645
<212>  DNA
<213>  Homosapiens

<400>  468
atggacgtca ggctcatctg caccaccgta cccaagatgg ccttcaacta cttgtctggc     60

agcaagtcca tttctatggc tggctgtgcc acacaaattt tcttctgtgt atcactgctt    120

ggctctgaat gctttctgtt ggctgttatg tcttatgact gctacattgc catttgccac    180

cctctaagat acaccaatct catgagaccc aaaatttgta gacttatgac tgccttctcc    240

tggatcctgg gctctacaga tggaatcatt tatgctgtag ccacattttc cttctcctac    300

tgtgggtctc gggaaatagc ccacttcttc tgtgagttac cttccctact aatcctctca    360

tgcaatgaca cgtcaatatt tgaaaaggtt attttcattt gctctatagt aatgcttgtt    420

ttccctgttg caatcatcat tgcttcctat gctggagtta ttctggctgt cattcacatg    480

ggatctggag agggtcgtcg caaagctttc acgacctgtt cctctcacct catggtggtg    540

ggaatgttct atggagcagg tttgttcatg tacatacagc ccacatctga tcgctcccca    600

acgcaggaca agctggtgtc tgtattctac accatcctca ctccc                    645


<210>  469
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  469
atggcatggg agaatcagac cttcaactct gacttcatcc tcctgggaat cttcaatcac     60

agccccaccc acaccttcct cttctttctg gtcctggcca tcttttcagt ggccttcatg    120

ggaaactctg tcatggttct cctcatctac ctggacaccc agctccacac ccccatgtac    180

ttcctcctca gtcaactgtt cctcatggac ctcatgctca tctgctctac cgtacccaag    240

atggccttca actacttgtc tggcagcaag tccatttcta tggctggttg tgccacacaa    300

attttcttct atgtatcact gcttggctcc gaatgctttc tgttggctgt tatgtcttat    360

gaccgctata ttgccatttg ccaccctcta agatacacca atctcatgag acccaaaatt    420

tgtggactta tgactgcctt ctcctggatc ctgggctcta tggatgcaat cattgatgct    480

gtagcgacat tttccttctc ctactgtggg tctcgggaaa tagcccactt cttctgtgac    540

ttcccttccc tactaatcct ctcatgcaat gacacatcaa tatttgaaaa ggttcttttc    600

atctgctgta tagtaatgat tgtttttcct gttgcaatca tcatcgcttc ctatgctcga    660

gttattctgg ctgtcattca catgggatct ggagagggtc gtcgcaaagc ttttactacc    720

tgttcctctc acctcatggt ggtgggaatg tactatggag caggtttgtt catgtacata    780

cggcccacat ctgatcgctc ccctatgcag gacaagctgg tgtctgtatt ctacaccatc    840

ctcactccca tgctgaatcc cctcatctac agcctccgca acaaggaggt gaccagagca    900

ctcaggaaag tgttaggaaa gggcaagtgt ggagagtga                           939


<210>  470
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  470

Met Ala Trp Glu Asn Gln Thr Phe Asn Ser Asp Phe Ile Leu Leu Gly 
1               5                   10                  15      


Ile Phe Asn His Ser Pro Thr His Thr Phe Leu Phe Phe Leu Val Leu 
            20                  25                  30          


Ala Ile Phe Ser Val Ala Phe Met Gly Asn Ser Val Met Val Leu Leu 
        35                  40                  45              


Ile Tyr Leu Asp Thr Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 
    50                  55                  60                  


Gln Leu Phe Leu Met Asp Leu Met Leu Ile Cys Ser Thr Val Pro Lys 
65                  70                  75                  80  


Met Ala Phe Asn Tyr Leu Ser Gly Ser Lys Ser Ile Ser Met Ala Gly 
                85                  90                  95      


Cys Ala Thr Gln Ile Phe Phe Tyr Val Ser Leu Leu Gly Ser Glu Cys 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Ile Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Thr Asn Leu Met Arg Pro Lys Ile Cys Gly Leu Met 
    130                 135                 140                 


Thr Ala Phe Ser Trp Ile Leu Gly Ser Met Asp Ala Ile Ile Asp Ala 
145                 150                 155                 160 


Val Ala Thr Phe Ser Phe Ser Tyr Cys Gly Ser Arg Glu Ile Ala His 
                165                 170                 175     


Phe Phe Cys Asp Phe Pro Ser Leu Leu Ile Leu Ser Cys Asn Asp Thr 
            180                 185                 190         


Ser Ile Phe Glu Lys Val Leu Phe Ile Cys Cys Ile Val Met Ile Val 
        195                 200                 205             


Phe Pro Val Ala Ile Ile Ile Ala Ser Tyr Ala Arg Val Ile Leu Ala 
    210                 215                 220                 


Val Ile His Met Gly Ser Gly Glu Gly Arg Arg Lys Ala Phe Thr Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Met Val Val Gly Met Tyr Tyr Gly Ala Gly Leu 
                245                 250                 255     


Phe Met Tyr Ile Arg Pro Thr Ser Asp Arg Ser Pro Met Gln Asp Lys 
            260                 265                 270         


Leu Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Thr Arg Ala Leu Arg Lys Val 
    290                 295                 300                 


Leu Gly Lys Gly Lys Cys Gly Glu 
305                 310         


<210>  471
<211>  1044
<212>  DNA
<213>  Homosapiens

<400>  471
atggcatggg agaatcagac cttcaactcc gacttcatcc tccttggaat cttcaatcac     60

agcccaccac acacgttcct cttctttctg gtcctgggca tctttttagt ggccttcatg    120

ggaaactctg tcatggttct cctcatctac ctggacaccc agctccacac ccccatgtac    180

ttcctcctca gccaactgtc cctcatggac ctcatgctca tctgcaccac cgtacccaag    240

atggccttca actacctgtc tggcagcaag tccatttcta tggctggttg tgtcacacaa    300

attttcttct atatatcact gtctggctct gaatgttttc ttttggctgt tatggcttat    360

gaccgctata ttgctatttg ccaccctcta agatatacca atctcatgaa tcctaaaatt    420

tgtggactta tggctacctt ctcctggatc ctgggctcta cagatggaat cattgatgct    480

gtagccacat tttccttctc cttttgtggg tctcgggaaa tagcccactt cttctgtgaa    540

ttcccttccc tactaatcct ctcatgcaat gacacatcaa tatttgaaga ggttattttc    600

atctgctgta tagtaatgct tgttttccct gttgcaatca tcattgcttc ctatgctcga    660

gttattctgg ctgtcattca catgggatct ggagagggtc gttgcaaagc tttcacgacc    720

tgttcctctc acctcatggt ggtgggaatg tactatggag cagctttgtt catgtacata    780

cggcccacat ctgatcactc cccaacgcag gacaagatgg tgtctgtatt ctacaccatc    840

ctcactccca tgctgaatcc cctcatctac agcctccgca acaaggaggt gactagagca    900

ttcatgaaga tcttaggaaa gggcaagtct gagagtgagt tacctcataa actttatgtt    960

ttgctgtttg ctaaattctt ctttctaata tccatctttt tctatgatgt caaaatacta   1020

gcattgatta tgtacattgc ctaa                                          1044


<210>  472
<211>  347
<212>  PRT
<213>  Homosapiens

<400>  472

Met Ala Trp Glu Asn Gln Thr Phe Asn Ser Asp Phe Ile Leu Leu Gly 
1               5                   10                  15      


Ile Phe Asn His Ser Pro Pro His Thr Phe Leu Phe Phe Leu Val Leu 
            20                  25                  30          


Gly Ile Phe Leu Val Ala Phe Met Gly Asn Ser Val Met Val Leu Leu 
        35                  40                  45              


Ile Tyr Leu Asp Thr Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 
    50                  55                  60                  


Gln Leu Ser Leu Met Asp Leu Met Leu Ile Cys Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Ala Phe Asn Tyr Leu Ser Gly Ser Lys Ser Ile Ser Met Ala Gly 
                85                  90                  95      


Cys Val Thr Gln Ile Phe Phe Tyr Ile Ser Leu Ser Gly Ser Glu Cys 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Thr Asn Leu Met Asn Pro Lys Ile Cys Gly Leu Met 
    130                 135                 140                 


Ala Thr Phe Ser Trp Ile Leu Gly Ser Thr Asp Gly Ile Ile Asp Ala 
145                 150                 155                 160 


Val Ala Thr Phe Ser Phe Ser Phe Cys Gly Ser Arg Glu Ile Ala His 
                165                 170                 175     


Phe Phe Cys Glu Phe Pro Ser Leu Leu Ile Leu Ser Cys Asn Asp Thr 
            180                 185                 190         


Ser Ile Phe Glu Glu Val Ile Phe Ile Cys Cys Ile Val Met Leu Val 
        195                 200                 205             


Phe Pro Val Ala Ile Ile Ile Ala Ser Tyr Ala Arg Val Ile Leu Ala 
    210                 215                 220                 


Val Ile His Met Gly Ser Gly Glu Gly Arg Cys Lys Ala Phe Thr Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Met Val Val Gly Met Tyr Tyr Gly Ala Ala Leu 
                245                 250                 255     


Phe Met Tyr Ile Arg Pro Thr Ser Asp His Ser Pro Thr Gln Asp Lys 
            260                 265                 270         


Met Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Thr Arg Ala Phe Met Lys Ile 
    290                 295                 300                 


Leu Gly Lys Gly Lys Ser Glu Ser Glu Leu Pro His Lys Leu Tyr Val 
305                 310                 315                 320 


Leu Leu Phe Ala Lys Phe Phe Phe Leu Ile Ser Ile Phe Phe Tyr Asp 
                325                 330                 335     


Val Lys Ile Leu Ala Leu Ile Met Tyr Ile Ala 
            340                 345         


<210>  473
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  473
atggcaaggg agaattcgac cttcaactcc gacttcatcc tcctgggaat cttcaatcac     60

agccccaccc acaccttcct cttctttctg gtcctggcca tcttttcagt ggccttcatg    120

ggaaactctg tcatggttct cctcatctac ctggacaccc agctccacac ccccatgtac    180

ctcctcctca gccaactgtc cctcatggac ctcatgctca tctgcaccac cgtacccaag    240

atggccttca actacctgtc tggcagcaag tccatttcta tggctggttg tgccacacaa    300

attttcttct atacatcact gcttggctct gagtgctttc ttttggctgt tatggcttat    360

gaccgctaca ctgccatttg ccaccctcta agatacacca atctcatgag ccctaaaatt    420

tgtggactta tgactgcctt ttcctggatc ctgggctcta cggatggaat tattgatgtt    480

gtagcaacat tttccttctc ctactgtggg tctcgggaaa tagcccactt cttctgtgac    540

ttcccctccc tactaatcct ctcatgcagt gacacatcaa tatttgaaaa gattcttttc    600

atctgctgta tagtaatgat tgttttccct gttgcaatca tcattgcttc ctatgctcga    660

gttatcctgg ctgtcattca catgggatct ggagagggtc gtcgcaaagc ttttactact    720

tgttcctctc acctcttggt ggtgggaatg tactatggag cagctttgtt catgtacata    780

cggcccacat ctgatcgctc cccaacacag gacaagatgg tgtctgtatt ctacaccatc    840

ctcactccca tgttgaatcc cctcatctac agcctccgca acaaggaggt gaccagagca    900

ttcatgaaga tcttaggaaa gggcaagtct ggagagtga                           939


<210>  474
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  474

Met Ala Arg Glu Asn Ser Thr Phe Asn Ser Asp Phe Ile Leu Leu Gly 
1               5                   10                  15      


Ile Phe Asn His Ser Pro Thr His Thr Phe Leu Phe Phe Leu Val Leu 
            20                  25                  30          


Ala Ile Phe Ser Val Ala Phe Met Gly Asn Ser Val Met Val Leu Leu 
        35                  40                  45              


Ile Tyr Leu Asp Thr Gln Leu His Thr Pro Met Tyr Leu Leu Leu Ser 
    50                  55                  60                  


Gln Leu Ser Leu Met Asp Leu Met Leu Ile Cys Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Ala Phe Asn Tyr Leu Ser Gly Ser Lys Ser Ile Ser Met Ala Gly 
                85                  90                  95      


Cys Ala Thr Gln Ile Phe Phe Tyr Thr Ser Leu Leu Gly Ser Glu Cys 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Thr Asn Leu Met Ser Pro Lys Ile Cys Gly Leu Met 
    130                 135                 140                 


Thr Ala Phe Ser Trp Ile Leu Gly Ser Thr Asp Gly Ile Ile Asp Val 
145                 150                 155                 160 


Val Ala Thr Phe Ser Phe Ser Tyr Cys Gly Ser Arg Glu Ile Ala His 
                165                 170                 175     


Phe Phe Cys Asp Phe Pro Ser Leu Leu Ile Leu Ser Cys Ser Asp Thr 
            180                 185                 190         


Ser Ile Phe Glu Lys Ile Leu Phe Ile Cys Cys Ile Val Met Ile Val 
        195                 200                 205             


Phe Pro Val Ala Ile Ile Ile Ala Ser Tyr Ala Arg Val Ile Leu Ala 
    210                 215                 220                 


Val Ile His Met Gly Ser Gly Glu Gly Arg Arg Lys Ala Phe Thr Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Leu Val Val Gly Met Tyr Tyr Gly Ala Ala Leu 
                245                 250                 255     


Phe Met Tyr Ile Arg Pro Thr Ser Asp Arg Ser Pro Thr Gln Asp Lys 
            260                 265                 270         


Met Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Thr Arg Ala Phe Met Lys Ile 
    290                 295                 300                 


Leu Gly Lys Gly Lys Ser Gly Glu 
305                 310         


<210>  475
<211>  936
<212>  DNA
<213>  Homosapiens

<400>  475
atggtgtggg aaaaccagac cttcaactcc atcttcatcc tgctgggaat cttcaatcac     60

agtcccaccc acaccttcct tttttctctg gtcctgggca tcttctcact ggcattgatg    120

gaaaatattt ccatggttct cctcatctac atagagaaac agctccacac ccccatgtac    180

ttcctcctca gtcaactgtc ccttatggac ctcatgctca tctgcaccac tctacccaag    240

atgatcttca gctacttgtc tgggaagaaa tctatctctc tggcaggttg tggaactcag    300

atattcttct atgtgtccct gcttggagct gaatgtttct tgttggctgt catggcttat    360

gaccgctatg tggctatatg tcaccctctt cagtacacca tcctcatgaa tccgaaactc    420

tgtgtcttca tgactgttgc ttcctggacc ttggggtctc ttgatgggat catagtgctt    480

gcagctgtcc tgtcattttc ttactgcagc tctctggaaa ttcatcactt tttctgtgat    540

gttgctgccc ttttacctct atcctgcaca gaaacatctg catttgaaag actacttgtc    600

atttgttgtg tggtaatgct aatctttcca gtttcagtta tcatactttc ctattcccat    660

gtccttcgag ccgtcatcca catgggctct ggggaaagtc gtcgcaaggc cttcactacc    720

tgctcctccc acctgtctgt ggtcggactc tactacggtg ctgctatgtt catgtacatg    780

agaccagctt ctaaacatac gccagaccag gacaagatgg tgtcggcctt ctacactatt    840

ctcaccccta tgctgaaccc tctcatttat agcctccgca acaaagaagt gttcagggca    900

ctacagaagg tactgaagaa aagaaagtta atatga                              936


<210>  476
<211>  311
<212>  PRT
<213>  Homosapiens

<400>  476

Met Val Trp Glu Asn Gln Thr Phe Asn Ser Ile Phe Ile Leu Leu Gly 
1               5                   10                  15      


Ile Phe Asn His Ser Pro Thr His Thr Phe Leu Phe Ser Leu Val Leu 
            20                  25                  30          


Gly Ile Phe Ser Leu Ala Leu Met Glu Asn Ile Ser Met Val Leu Leu 
        35                  40                  45              


Ile Tyr Ile Glu Lys Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 
    50                  55                  60                  


Gln Leu Ser Leu Met Asp Leu Met Leu Ile Cys Thr Thr Leu Pro Lys 
65                  70                  75                  80  


Met Ile Phe Ser Tyr Leu Ser Gly Lys Lys Ser Ile Ser Leu Ala Gly 
                85                  90                  95      


Cys Gly Thr Gln Ile Phe Phe Tyr Val Ser Leu Leu Gly Ala Glu Cys 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Gln Tyr Thr Ile Leu Met Asn Pro Lys Leu Cys Val Phe Met 
    130                 135                 140                 


Thr Val Ala Ser Trp Thr Leu Gly Ser Leu Asp Gly Ile Ile Val Leu 
145                 150                 155                 160 


Ala Ala Val Leu Ser Phe Ser Tyr Cys Ser Ser Leu Glu Ile His His 
                165                 170                 175     


Phe Phe Cys Asp Val Ala Ala Leu Leu Pro Leu Ser Cys Thr Glu Thr 
            180                 185                 190         


Ser Ala Phe Glu Arg Leu Leu Val Ile Cys Cys Val Val Met Leu Ile 
        195                 200                 205             


Phe Pro Val Ser Val Ile Ile Leu Ser Tyr Ser His Val Leu Arg Ala 
    210                 215                 220                 


Val Ile His Met Gly Ser Gly Glu Ser Arg Arg Lys Ala Phe Thr Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Ser Val Val Gly Leu Tyr Tyr Gly Ala Ala Met 
                245                 250                 255     


Phe Met Tyr Met Arg Pro Ala Ser Lys His Thr Pro Asp Gln Asp Lys 
            260                 265                 270         


Met Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Phe Arg Ala Leu Gln Lys Val 
    290                 295                 300                 


Leu Lys Lys Arg Lys Leu Ile 
305                 310     


<210>  477
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  477
atggagatga gaaatactac cccagatttt attctcctag gactctttaa ccacaccaga     60

gcccaccaag tcctcttcat gatggttctg agtatcgttt tgacctccct gtttggcaat    120

tccctcatga ttctcctgat tcactgggac caccggctcc acacgcccat gtacttcctc    180

ctgagccaac tttccctcat ggacatgatg ctggtttcca ccactgtgcc caaaatggcg    240

gctgactact tgaccggaag taaggccatc tcccgcgctg gctgtggtgt gcagatcttc    300

ttcctcccca cactgggtgg tggagagtgc ttcctcttag cagccatggc ctatgaccgc    360

tatgcggctg tctgccaccc actccgatat cccactctca tgagctggca gctgtgcctg    420

aggatgacca tgtcgtgttg gctcctgggt gcagctgacg ggctcctgca ggctgttgtt    480

accctgagct tcccatattg tggtgcacac gagatcgatc acttcttctg cgagaccccc    540

gtgctggtgc gtttggcttg tgctgacact tcagtcttcg aaaacgccat gtacatctgc    600

tgtgtgttaa tgctcctggt ccccttttcc ctcatcctgt cctcctatgg tctcatcctc    660

gctgctgttc tgcacatgcg ctctacagaa gcccgcaaga aggcctttgc cacctgctct    720

tcacatgtgg ctgtggtggg actcttttat ggagctgcca tttttaccta tatgagaccc    780

aaatcccata ggtccactaa ccatgacaag gttgtgtcag ccttctatac tatgttcacc    840

cctttactaa accccctcat ctacagtgtg aagaacagtg aggtgaaggg agccctgaaa    900

cggtggctgg ggacgtgtgt aaacataaaa caccagcaaa atgaggccca caggtcaaga    960

tga                                                                  963


<210>  478
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  478

Met Glu Met Arg Asn Thr Thr Pro Asp Phe Ile Leu Leu Gly Leu Phe 
1               5                   10                  15      


Asn His Thr Arg Ala His Gln Val Leu Phe Met Met Val Leu Ser Ile 
            20                  25                  30          


Val Leu Thr Ser Leu Phe Gly Asn Ser Leu Met Ile Leu Leu Ile His 
        35                  40                  45              


Trp Asp His Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu 
    50                  55                  60                  


Ser Leu Met Asp Met Met Leu Val Ser Thr Thr Val Pro Lys Met Ala 
65                  70                  75                  80  


Ala Asp Tyr Leu Thr Gly Ser Lys Ala Ile Ser Arg Ala Gly Cys Gly 
                85                  90                  95      


Val Gln Ile Phe Phe Leu Pro Thr Leu Gly Gly Gly Glu Cys Phe Leu 
            100                 105                 110         


Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys His Pro Leu 
        115                 120                 125             


Arg Tyr Pro Thr Leu Met Ser Trp Gln Leu Cys Leu Arg Met Thr Met 
    130                 135                 140                 


Ser Cys Trp Leu Leu Gly Ala Ala Asp Gly Leu Leu Gln Ala Val Val 
145                 150                 155                 160 


Thr Leu Ser Phe Pro Tyr Cys Gly Ala His Glu Ile Asp His Phe Phe 
                165                 170                 175     


Cys Glu Thr Pro Val Leu Val Arg Leu Ala Cys Ala Asp Thr Ser Val 
            180                 185                 190         


Phe Glu Asn Ala Met Tyr Ile Cys Cys Val Leu Met Leu Leu Val Pro 
        195                 200                 205             


Phe Ser Leu Ile Leu Ser Ser Tyr Gly Leu Ile Leu Ala Ala Val Leu 
    210                 215                 220                 


His Met Arg Ser Thr Glu Ala Arg Lys Lys Ala Phe Ala Thr Cys Ser 
225                 230                 235                 240 


Ser His Val Ala Val Val Gly Leu Phe Tyr Gly Ala Ala Ile Phe Thr 
                245                 250                 255     


Tyr Met Arg Pro Lys Ser His Arg Ser Thr Asn His Asp Lys Val Val 
            260                 265                 270         


Ser Ala Phe Tyr Thr Met Phe Thr Pro Leu Leu Asn Pro Leu Ile Tyr 
        275                 280                 285             


Ser Val Lys Asn Ser Glu Val Lys Gly Ala Leu Lys Arg Trp Leu Gly 
    290                 295                 300                 


Thr Cys Val Asn Ile Lys His Gln Gln Asn Glu Ala His Arg Ser Arg 
305                 310                 315                 320 


<210>  479
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  479
atggagatga gaaatactac cccagatttt attctcctag gactctttaa ccacaccaga     60

gcccaccaag tcctcttcat gatgcttctg gccaccgttt tgacctccct gtttagcaat    120

gccctcatga ttctcctgat tcactgggac caccggctcc acaggcccat gtacttcctc    180

ctgagccaac tttccctcat ggacatgatg ctggtttcca ccactgtgcc caaaatggcg    240

gctgactact tgaccggaaa taaggccatc tcccgcgctg gctgtggtgt gcagatcttc    300

ttcctcccca cactgggtgg tggagagtgc ttcctcttag cagccatggc ctatgaccgc    360

tatgcggctg tctgccaccc actccgatat cccactctca tgagctggca gctgtgcctg    420

aggatgacca tgtcgtcctg gctcctgggt gcagctgacg gcctcctgca ggctgttgct    480

accctgagct tcccatattg cggtgcacac gagatcgatc acttcttctg cgaggccccc    540

gtgttggtgc gtttggcttg tgctgacact tcagtcttcg aaaacgccat gtacatctgc    600

tgtgtgttaa tgctcctggt ccccttttcc ctcatcctgt cctcctatgg tctcatcctc    660

gctgctgttc tgctcatgcg ctctacagaa gcccgcaaga aggcctttgc cacctgctct    720

tcacatgtgg ctgtggtggg actcttttat ggagctggca tttttaccta tatgagaccc    780

aaatcccaca ggtccactaa ccacgataag gttgtgtcag ccttctatac tatgttcacc    840

cctttactaa atcccctcat ctacagtgtg aggaacagtg aggtcaagga agccctgaaa    900

cggtggctgg ggacgtgtgt aaacctaaaa caccagcaaa atgaggccca caggtcaaga    960

tga                                                                  963


<210>  480
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  480

Met Glu Met Arg Asn Thr Thr Pro Asp Phe Ile Leu Leu Gly Leu Phe 
1               5                   10                  15      


Asn His Thr Arg Ala His Gln Val Leu Phe Met Met Leu Leu Ala Thr 
            20                  25                  30          


Val Leu Thr Ser Leu Phe Ser Asn Ala Leu Met Ile Leu Leu Ile His 
        35                  40                  45              


Trp Asp His Arg Leu His Arg Pro Met Tyr Phe Leu Leu Ser Gln Leu 
    50                  55                  60                  


Ser Leu Met Asp Met Met Leu Val Ser Thr Thr Val Pro Lys Met Ala 
65                  70                  75                  80  


Ala Asp Tyr Leu Thr Gly Asn Lys Ala Ile Ser Arg Ala Gly Cys Gly 
                85                  90                  95      


Val Gln Ile Phe Phe Leu Pro Thr Leu Gly Gly Gly Glu Cys Phe Leu 
            100                 105                 110         


Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys His Pro Leu 
        115                 120                 125             


Arg Tyr Pro Thr Leu Met Ser Trp Gln Leu Cys Leu Arg Met Thr Met 
    130                 135                 140                 


Ser Ser Trp Leu Leu Gly Ala Ala Asp Gly Leu Leu Gln Ala Val Ala 
145                 150                 155                 160 


Thr Leu Ser Phe Pro Tyr Cys Gly Ala His Glu Ile Asp His Phe Phe 
                165                 170                 175     


Cys Glu Ala Pro Val Leu Val Arg Leu Ala Cys Ala Asp Thr Ser Val 
            180                 185                 190         


Phe Glu Asn Ala Met Tyr Ile Cys Cys Val Leu Met Leu Leu Val Pro 
        195                 200                 205             


Phe Ser Leu Ile Leu Ser Ser Tyr Gly Leu Ile Leu Ala Ala Val Leu 
    210                 215                 220                 


Leu Met Arg Ser Thr Glu Ala Arg Lys Lys Ala Phe Ala Thr Cys Ser 
225                 230                 235                 240 


Ser His Val Ala Val Val Gly Leu Phe Tyr Gly Ala Gly Ile Phe Thr 
                245                 250                 255     


Tyr Met Arg Pro Lys Ser His Arg Ser Thr Asn His Asp Lys Val Val 
            260                 265                 270         


Ser Ala Phe Tyr Thr Met Phe Thr Pro Leu Leu Asn Pro Leu Ile Tyr 
        275                 280                 285             


Ser Val Arg Asn Ser Glu Val Lys Glu Ala Leu Lys Arg Trp Leu Gly 
    290                 295                 300                 


Thr Cys Val Asn Leu Lys His Gln Gln Asn Glu Ala His Arg Ser Arg 
305                 310                 315                 320 


<210>  481
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  481
atggcatggg agaatcagac cttcaactct gacttcctcc tcctgggaat cttcaatcat     60

agccccaccc acaccttcct cttctttctg gtcctggcca tcttttcagt ggccttcatg    120

ggaaactcca tcatggttct cctcatctac ctggataccc agctccacac ccccatgtac    180

ttcctcctca gccaactgtc cctcatggac ctcatgctca tctgcaccac tgtacccaag    240

atggccttca actacttgtc tggcagcaag tccatttcta tggctggctg tgccacacaa    300

attttcttct atatatcatt gcttggctcc gaatgctttc tgttggctgt tatgtcttat    360

gaccgctaca ctgccatttg ccaccctcta agatacacca atctcatgag acccaaaatt    420

tgtggactta tgactgcctt ctcctggatc ctgggctcta cagatggaat cattgatgct    480

gtagcgacat tttccttctc ctactgtggg tctcgggaaa tagcccactt ctgctgtgac    540

ttcccttccc tactaatcct ctcatgcaat gacacatcaa tatttgaaga ggttattttc    600

atctgctgta tagtaatgct tgttttccct gttgcaatca tcatcacttc ctatgctcga    660

gttattctgg ctgtcattca catgggatct ggagagggac gtcgcaaagc ttttactact    720

tgttcctctc acctcatggt ggtgggaatg tactatggag caggtttgtt catgtgcatt    780

cagcccacat ctcatcattc tcctatgcag gacaagatgg tgtctgtatt ctacaccatc    840

gtcactccca tgctgaatcc tctcatttat agcctccgca acaaggaagt gaccagagca    900

ttaatgaaaa tcttaggaaa gggcaagtct ggagattga                           939


<210>  482
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  482

Met Ala Trp Glu Asn Gln Thr Phe Asn Ser Asp Phe Leu Leu Leu Gly 
1               5                   10                  15      


Ile Phe Asn His Ser Pro Thr His Thr Phe Leu Phe Phe Leu Val Leu 
            20                  25                  30          


Ala Ile Phe Ser Val Ala Phe Met Gly Asn Ser Ile Met Val Leu Leu 
        35                  40                  45              


Ile Tyr Leu Asp Thr Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 
    50                  55                  60                  


Gln Leu Ser Leu Met Asp Leu Met Leu Ile Cys Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Ala Phe Asn Tyr Leu Ser Gly Ser Lys Ser Ile Ser Met Ala Gly 
                85                  90                  95      


Cys Ala Thr Gln Ile Phe Phe Tyr Ile Ser Leu Leu Gly Ser Glu Cys 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Thr Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Thr Asn Leu Met Arg Pro Lys Ile Cys Gly Leu Met 
    130                 135                 140                 


Thr Ala Phe Ser Trp Ile Leu Gly Ser Thr Asp Gly Ile Ile Asp Ala 
145                 150                 155                 160 


Val Ala Thr Phe Ser Phe Ser Tyr Cys Gly Ser Arg Glu Ile Ala His 
                165                 170                 175     


Phe Cys Cys Asp Phe Pro Ser Leu Leu Ile Leu Ser Cys Asn Asp Thr 
            180                 185                 190         


Ser Ile Phe Glu Glu Val Ile Phe Ile Cys Cys Ile Val Met Leu Val 
        195                 200                 205             


Phe Pro Val Ala Ile Ile Ile Thr Ser Tyr Ala Arg Val Ile Leu Ala 
    210                 215                 220                 


Val Ile His Met Gly Ser Gly Glu Gly Arg Arg Lys Ala Phe Thr Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Met Val Val Gly Met Tyr Tyr Gly Ala Gly Leu 
                245                 250                 255     


Phe Met Cys Ile Gln Pro Thr Ser His His Ser Pro Met Gln Asp Lys 
            260                 265                 270         


Met Val Ser Val Phe Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Thr Arg Ala Leu Met Lys Ile 
    290                 295                 300                 


Leu Gly Lys Gly Lys Ser Gly Asp 
305                 310         


<210>  483
<211>  1609
<212>  DNA
<213>  Homosapiens

<400>  483
acatctcgcg gcgaggagga gaggccggaa gggcgcccca gccccaaggc tcctgccccg     60

cctgggcctc cggctttcgt ttccccgcaa cgcttcgctt tcgtttcccg ctggcgcctg    120

gctccctccg ggtttcgttt cccgccggcg cctggctccc gccaggtttc gtttccgagg    180

cggggccgag ggcggcgtcg ctgaggcgcc catggccttc gcccgccggc tcctgcgcgg    240

gccactgtcg gggccgctgc tcgggcggcg cggggtctgc gctggggcca tggctccgcc    300

gcgccgcttc gtcctggagc ttcccgactg caccctggct cacttcgccc taggcgccga    360

cgcccccggc gacgcagacg cccccgaccc ccgcctggcg gcgctgctgg ggcccccgga    420

gcgcagctac tcgctgtgcg tgcccgtgac cccggacgcc ggctgcgggg cccgggtccg    480

ggcggcgcgg ctgcaccagc gcctgctgca ccagctgcgc cgcggcccct tccagcggtg    540

ccagctgctc aggctgctct gctactgccc gggcggccag gccggcggcg cacagcaagg    600

cttcctgctg cgcgaccccc tggatgaccc tgacacccgg caagcgctgc tcgagctgct    660

gggcgcctgc caggaggcac cacgcccgca cttgggcgag ttcgaggccg acccgcgcgg    720

ccagctgtgg cagcgcctct gggaggtgca agacggcagg cggctgcagg tgggctgcgc    780

acaggtcgtg cccgtcccgg agcccccgct gcacccggtg gtgccagact tgcccagttc    840

cgtggtcttc ccggaccggg aagccgcccg ggccgttttg gaggagtgta cctcctttat    900

tcctgaagcc cgggcagtgc ttgacctggt cgaccagtgc ccaaaacaga tccagaaagg    960

aaagttccag gttgttgcca tcgaaggact ggatgccacg ggtaaaacca cggtgaccca   1020

gtcagtggca gattcactta aggctgtccc ccagcccatc accctgtgta ccagtggcca   1080

gaggacctgc tcaaacctga ccttatcctg ctgctcactg tgagtcctga ggagaggttg   1140

cagaggctgc agggccgggg catggagaag accagggaag aagcagaact tgaggccaac   1200

agtgtgtttc gtcaaaaggt agaaatgtcc taccagcgga tggagaatcc tggctgccat   1260

gtggttgatg ccagcccctc cagagaaaag gtcctgcaga cggtcccagc tgggaggaac   1320

cttataccat ccttctctcc acctgctcgg cagtgaagtt tgtgggactg gaatcttgga   1380

ttcatcacac tcgagtcaag gcctggaatg acccctgaca tcccagaaga acatctcaga   1440

tatcagtgtg aaaagtctgg ggatttcaaa ctgaaaatcc aaaagataag taaatgagtg   1500

ggaactctct gttcagttca atcccaccct tccttaccag atactaaagt catttctacc   1560

tttcctcttg agatttgctg ttagatatta gaacttctct ttgtcacat               1609


<210>  484
<211>  303
<212>  PRT
<213>  Homosapiens

<400>  484

Met Ala Phe Ala Arg Arg Leu Leu Arg Gly Pro Leu Ser Gly Pro Leu 
1               5                   10                  15      


Leu Gly Arg Arg Gly Val Cys Ala Gly Ala Met Ala Pro Pro Arg Arg 
            20                  25                  30          


Phe Val Leu Glu Leu Pro Asp Cys Thr Leu Ala His Phe Ala Leu Gly 
        35                  40                  45              


Ala Asp Ala Pro Gly Asp Ala Asp Ala Pro Asp Pro Arg Leu Ala Ala 
    50                  55                  60                  


Leu Leu Gly Pro Pro Glu Arg Ser Tyr Ser Leu Cys Val Pro Val Thr 
65                  70                  75                  80  


Pro Asp Ala Gly Cys Gly Ala Arg Val Arg Ala Ala Arg Leu His Gln 
                85                  90                  95      


Arg Leu Leu His Gln Leu Arg Arg Gly Pro Phe Gln Arg Cys Gln Leu 
            100                 105                 110         


Leu Arg Leu Leu Cys Tyr Cys Pro Gly Gly Gln Ala Gly Gly Ala Gln 
        115                 120                 125             


Gln Gly Phe Leu Leu Arg Asp Pro Leu Asp Asp Pro Asp Thr Arg Gln 
    130                 135                 140                 


Ala Leu Leu Glu Leu Leu Gly Ala Cys Gln Glu Ala Pro Arg Pro His 
145                 150                 155                 160 


Leu Gly Glu Phe Glu Ala Asp Pro Arg Gly Gln Leu Trp Gln Arg Leu 
                165                 170                 175     


Trp Glu Val Gln Asp Gly Arg Arg Leu Gln Val Gly Cys Ala Gln Val 
            180                 185                 190         


Val Pro Val Pro Glu Pro Pro Leu His Pro Val Val Pro Asp Leu Pro 
        195                 200                 205             


Ser Ser Val Val Phe Pro Asp Arg Glu Ala Ala Arg Ala Val Leu Glu 
    210                 215                 220                 


Glu Cys Thr Ser Phe Ile Pro Glu Ala Arg Ala Val Leu Asp Leu Val 
225                 230                 235                 240 


Asp Gln Cys Pro Lys Gln Ile Gln Lys Gly Lys Phe Gln Val Val Ala 
                245                 250                 255     


Ile Glu Gly Leu Asp Ala Thr Gly Lys Thr Thr Val Thr Gln Ser Val 
            260                 265                 270         


Ala Asp Ser Leu Lys Ala Val Pro Gln Pro Ile Thr Leu Cys Thr Ser 
        275                 280                 285             


Gly Gln Arg Thr Cys Ser Asn Leu Thr Leu Ser Cys Cys Ser Leu 
    290                 295                 300             


<210>  485
<211>  3512
<212>  DNA
<213>  Homosapiens

<400>  485
aactcagctg agtgttagtc aaagaaggtg tgtcctgctc cccaatgaca ggttgctcag     60

agactgctga tttccatccc tatataaaga gagtccctgg catacagaga ctgctctgct    120

ccaggcatct gccacaatgt gggtgcttac acctgctgct tttgctggga agctcttgag    180

tgtgttcagg caacctctga gctctctgtg gaggagcctg gtcccgctgt tctgctggct    240

gagggcaacc ttctggctgc tagctaccaa gaggagaaag cagcagctgg tcctgagagg    300

gccagatgag accaaagagg aggaagagga ccctcctctg cccaccaccc caaccagcgt    360

caactatcac ttcactcgcc agtgcaacta caaatgcggc ttctgtttcc acacagccaa    420

aacatccttt gtgctgcccc ttgaggaagc aaagagagga ttgcttttgc ttaaggaagc    480

tggtatggag aagatcaact tttcaggtgg agagccattt cttcaagacc ggggagaata    540

cctgggcaag ttggtgaggt tctgcaaagt agagttgcgg ctgcccagcg tgagcatcgt    600

gagcaatgga agcctgatcc gggagaggtg gttccagaat tatggtgagt atttggacat    660

tctcgctatc tcctgtgaca gctttgacga ggaagtcaat gtccttattg gccgtggcca    720

aggaaagaag aaccatgtgg aaaaccttca aaagctgagg aggtggtgta gggattatag    780

agtcgctttc aagataaatt ctgtcattaa tcgtttcaac gtggaagagg acatgacgga    840

acagatcaaa gcactaaacc ctgtccgctg gaaagtgttc cagtgcctct taattgaggg    900

tgagaattgt ggagaagatg ctctaagaga agcagaaaga tttgttattg gtgatgaaga    960

atttgaaaga ttcttggagc gccacaaaga agtgtcctgc ttggtgcctg aatctaacca   1020

gaagatgaaa gactcctacc ttattctgga tgaatatatg cgctttctga actgtagaaa   1080

gggacggaag gacccttcca agtccatcct ggatgttggt gtagaagaag ctataaaatt   1140

cagtggattt gatgaaaaga tgtttctgaa gcgaggagga aaatacatat ggagtaaggc   1200

tgatctgaag ctggattggt agagcggaaa gtggaacgag acttcaacac accagtggga   1260

aaactcctag agtaactgcc attgtctgca atactatccc gttggtattt cccagtggct   1320

gaaaacctga ttttctgctg cacgtggcat ctgattacct gtggtcactg aacacacgaa   1380

taacttggat agcaaatcct gagacaatgg aaaaccatta actttacttc attggcttat   1440

aaccttgttg ttattgaaac agcacttctg tttttgagtt tgttttagct aaaaagaagg   1500

aatacacaca ggaataatga ccccaaaaat gcttagataa ggcccctata cacaggacct   1560

gacatttagc tcaatgatgc gtttgtaaga aataagctct agtgatatct gtgggggcaa   1620

aatttaattt ggatttgatt ttttaaaaca atgtttactg cgatttctat atttccattt   1680

tgaaactatt tcttgttcca ggtttgttca tttgacagag tcagtatttt ttgccaaata   1740

tccagataac cagttttcac atctgagaca ttacaaagta tctgcctcaa ttatttctgc   1800

tggttataat gctttttttt ttttgccttt atgccattgc agtcttgtac tttttactgt   1860

gatgtacaga aatagtcaac agatgtttcc aagaacatat gatatgataa tcctaccaat   1920

tttcaagaag tctctagaaa gagataacac atggaaagac ggtgtggtgc agcccagccc   1980

acggtggctg ttccatgaat gctggctacc tatgtgtgtg gtacctgttg tgtccctttc   2040

tcttcaaaga tcctgagcaa aacaaagata cgctttccat ttgatgatgg agttgacatg   2100

gaggcagtgc ttgcattgct ttgttcgcct atcatctggc cacatgaggc tgtcaagcaa   2160

aagaatagga gtgtagttga gtagctggtt ggccctacat ctctgagaag tgacggcaca   2220

ctgggttggc ataagatatc ctaaaatcac gctggaacct tgggcaagga agaatgtgag   2280

caagagtaga gagagtgcct ggatttcatg tcagtgaagc caagtcacca tatcatattt   2340

ttgaatgaac tctgagtcag ttgaaatagg gtaccatcta ggtcagttta agaagagtca   2400

gctcagagaa agcaagcata agggaaaatg tcacgtaaac tagatcaggg aacaaaatcc   2460

tctccttgtg gaaatatccc atgcagtttg ttgatacaac ttagtatctt attgcctaaa   2520

aaaaaatttc ttatcattgt ttcaaaaaag caaaatcatg gaaaattttt gttgtccagg   2580

caaataaaag gtcattttaa tttagctgca atttcagtgt tcctcactag gtggcattta   2640

aatgtcgcct gatgtcatta agcaccatcc aaaaagtctg cttcataatc tattttcaag   2700

acttggtgat tctgaaagtt ttggtttttg tgactttgtt tctcaggaaa aaaaatattc   2760

ctacttaaat tttaagtcta taattcaatt taaatatgtg tgtgtctcat ccaggatagg   2820

ataggttgtc ttctattttc cattttacct atttactttt tttgtaagaa aagagaaaaa   2880

tgaattctaa agatgttccc catgggtttt gattgtgtct aagctatgat gaccttcata   2940

taatcagcat aaacataaaa caaatttttt acttaacatg agtgcacttt actaatcctc   3000

atggcacagt ggctcacgcc tgtaatccca gcacttggga ggacaatgtg ggtggatcac   3060

gaggtcagga gttcgagaac agcctggcca acatggtgaa accccgtctc cactaaaaat   3120

acaaaaatta gccaggcatg gtggcgtaca cttgtaattc cagctactca agaggctgag   3180

gcaggaggat tgcttgaacc ctgaaggcag aggttacaga gccaagatag cgccactgca   3240

ctccagcctg gatgacagag caagactccg tctcaaaaaa aaaaaaaaaa aaaagcaaga   3300

gagttcaact aagaaaggtc acatatgtga aagcccaagg acactgtttg atatacagca   3360

ggtattcaat cagtgttatt tgaaaccaaa tctgaatttg aagtttgaat cttctgagtt   3420

ggaatgaatt tttttctagc tgagggaaac tgtatttttc tttccccaaa gaggaatgta   3480

atgtaaagtg aaataaaact ataagctatg tt                                 3512


<210>  486
<211>  361
<212>  PRT
<213>  Homosapiens

<400>  486

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
            100                 105                 110         


Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
        115                 120                 125             


Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
    130                 135                 140                 


Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                165                 170                 175     


Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
            180                 185                 190         


Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
        195                 200                 205             


Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
    210                 215                 220                 


Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
225                 230                 235                 240 


Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                245                 250                 255     


Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
            260                 265                 270         


Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
        275                 280                 285             


Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
    290                 295                 300                 


Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
305                 310                 315                 320 


Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                325                 330                 335     


Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
            340                 345                 350         


Ser Lys Ala Asp Leu Lys Leu Asp Trp 
        355                 360     


<210>  487
<211>  5755
<212>  DNA
<213>  Homosapiens

<400>  487
gagcctcccg cgtgcccggc ctctgtgcgc gctcgcgccc cgcccgcgca gccgcttctc     60

cccgcgcggg ctctcggcag gcgggaggcg gcagggctgg cattgcagtg cgggccgtgc    120

gggctgcgcg ggcgcgggga ggcgcgggcg gcaaactgcg ggcacccggc accccgcagc    180

cagtaccggg cggaggcgtc agagccgcgc accgcggacg agcaggccca ggcatccagt    240

accctgctga ctctgacatg cccccagcct cccccagctc tgcagggagc cctggtgcca    300

gagaccttct cccatttctc cctatgggtg cctgacctga gggcagagac atctgagtgt    360

gtataagcac agcaggacac caggacctgg cctgaagaca tttcctctcc tcccctctgg    420

atttctcaga gactgttctg cgatgaccac aacaaggtac cggcccacct gggacctggc    480

cctcgacccg ctggtgtctt gcaagctctg tcttggggag tacccagtgg agcagatgac    540

aaccatagcc cagtgccaat gcatcttctg tactctgtgc ctgaaacagt atgttgagct    600

cttgatcaaa gaaggattag aaaccgcaat tagctgccca gatgctgcct gccctaaaca    660

gggccaccta caggagaacg agattgagtg catggttgca gctgaaatta tgcaaagata    720

taaaaagcta caatttgaaa gagaggtgct gtttgatccc tgtcggactt ggtgcccggc    780

gtccacctgc caagctgtgt gtcagctcca ggacgtgggg ctgcagaccc cccagccagt    840

gcagtgcaaa gcctgccgta tggaattctg ctccacctgc aaagccagct ggcaccctgg    900

ccagggctgc ccggagacca tgccgatcac cttcctcccc ggggagacca gtgctgcttt    960

caaaatggaa gaagatgacg cgcccatcaa gcgctgcccc aagtgcaaag tctacatcga   1020

gcgagacgaa ggctgcgcgc agatgatgtg caagaactgc aagcacgcct tctgctggta   1080

ctgcctggag tctctggacg atgatttcct tctgatacac tacgataagg gaccctgccg   1140

gaacaagctg ggccactccc gggcatctgt gatctggcat cggacacagg ttgtgggcat   1200

ttttgcagga tttgggctgc tgctcttggt ggcctcacct ttcctactcc tggccactcc   1260

ctttgtactt tgctgcaagt gcaagtgcag taaaggtgac gacgacccgt tacccaccta   1320

gaggaagcgc gatgctggaa cacatccctg cctccgggaa gtgtggctct cccccaaccc   1380

tccccaccgt ccccccttca ctaaacatct ttcttgcctt atgtgcccca ttgagcttca   1440

cagtgtcagg ctggacgccg tgatttcagg gacctatgtc acaatgttcg ctgaggcccc   1500

aggtgtggtg gggaggggag gcaggtgtgg gtagcgcaca tccccacaga tcaatctctg   1560

cagatgacag ggaggtgctg tgagaagtgc accaggcagc tttctctctg tggtagacta   1620

ggcatgtctg gggatggcct aagagacttt ctgctccttg gcttctagat ggcaccatgt   1680

tgtcagagaa gtcttttaag gactgccact ctcttcagac agaatctgat tattccagct   1740

tgagagaagc actctgttta tgacaactgt ttttattact aatggcattt agtaaaatcc   1800

tttttagaag gtattttttt tccaactgag tagtgaaaat caacaaggtg catataaacc   1860

atcctatgcc tttcttgaaa tgtgcatttt aagaagttat agttaaacga cttttcagga   1920

gatttagaaa gccttatgca ctctttgtgt ttttcttgaa acttgctgta gtaacttttt   1980

gaacgctgta agctgtgtac tgttataagt gtgcttccta tattgttgca tttccttgat   2040

aatattgacg tgtttaaagg aacatctcat ctccattaga tttgcctttt gttgttttct   2100

ctctttggtg attcagctca gctcatgggc ctcatccctt ctctcccagg tagcagaaaa   2160

cgctttttat tgtattcaat cccactgctt tgctcggcaa tggttctcct ccgaattgct   2220

gccgtctggc ctctggcctc agtcttcaga tagacagtaa gaagaaagca gcctcattga   2280

tccgcagatg taggggcctc ttggcagagg ctggaggact ctgggggcta gggaagagcc   2340

tgccagattt tcacattttt aaaatgttct agtcattttg agaaatcata tatcttacac   2400

agttccaagt cctgttgcta accgttttgc tcttgttggg gaaaagaacc tcccatttca   2460

cttcgtttta acgtggggat tttaccactt gatcttttac agggctgtct gtgaccattt   2520

ccatggcagc aggatgcagg gattaataag gacacataca cattattcca ccaattgact   2580

ttgaaaagtg gagaaagtgt attctttaaa gagaatttac ttctaaaagc cacaggtgct   2640

tttacaaagc aaactgcatt gaatttaaaa cttctaaaaa taacaggcaa atattgtagc   2700

tatattacag tgggatttta aaaatcttgt taaacattct ataaagaagt aaaacaaaat   2760

ccttttatct cagttatttg cccatcacaa gcacattttt aaaatgttgc tttgtgtgtg   2820

tttgacttct gcatttgagt atcagtctca ggtcctagtt tactttccct ggttggaaat   2880

ttatttctta tttcctaaca ttgaattcgt tagaaaaaac agcgtcacct cactcttcac   2940

ctgtcatgtt gattttcctt atgaacccga agccatttag aaaatccctg tgtgtcaaaa   3000

ttacattcaa aaagctctcc ttgtaattgc aagtttagta actcagtaag aacatgcctg   3060

cgactccctt tctggatgga acctgggctg tggctctctg tcgtttgtgg tgctgtgatg   3120

gtgtctactg ttagaatagc ttttctggag gtgggtggca actccacgcg ggagtcattg   3180

gctgggcttg agccctcagc ctgtgatatg tggatgcagc tgtccagcca ctgcccttta   3240

acatgcccag cacacatggg aggcctgtgg ccctgtgtcc agtggcccac aggacacgcc   3300

tccaccatat gctcatcctt cctgcctgaa attgctgctg cccatcgcat gagcccacac   3360

agtagcaccc ccgtccttag gatgagagtc agagcctttg gaaaggctgc atccccaggg   3420

ctagagctca gatgacctta tttctagagg gacaggctgt tctgttggaa gagtctctgg   3480

cccagtcatg cacatctgta gccccagcca tccttgtgcc ttcacctctg atgtgtttca   3540

caagcacgta gttcaaccca gatagggacc acagagattc tggggccagc caggggcagt   3600

caaattggca cctactggct ctgacttttt gtatgaagca tgcctcagtt tcctcatttt   3660

gatctagata taaaattaaa attgtccatt tcctatataa ataccagcaa gatcactctg   3720

agatacataa actcgcattt ccttctgttt tagtaaggag tgccagactt atctttgatg   3780

ggaatacagt atgaaccctg cttgatgtaa aatggaaata gcacacaggc agatggccct   3840

gggtttggac tttgatcttg ccatcattcc ccagtaaaac ctggggagtt ctgcgttgag   3900

tggacggact tattcctgtg aagcggcata atttgtctcc attgaaaaat ggcattcact   3960

cttacagatg gtgttcactg caagccccag aagcatatgg catgtgttca ctaagaggcc   4020

tttaatcctg gggagtaagg ggcgaaggcc cttagacaac catggctgct gtactgccgc   4080

ccagggtggg tggccagtga ggactggcct tagcccagtg gacctgtggc ttctctgagg   4140

cccttgagta actgaccaca tttggaggtt ttgctggaaa tgcctgacct ctcagtctgg   4200

ctctgctgtg tagtccatag cccagccaga tgagcttgca gcctcatagg aggtcagcac   4260

cttgcaaaga tgcagtcacc atagatgtcc acgtagcaga gactgactta ggatctgaga   4320

taaagcatcg gattgcagga ataactgtcc aaattagttc ttcctcctca actcatagga   4380

gtagctgtgg acagaggaac caacatctgc cacctctggc attttctttc tttttttttc   4440

tttttgagac ggagtttcgc ttttgtcccc caagctggag tacaatgaca ggatctcggc   4500

tcactgcaag ctctgcctcc cgggttcaag cgattctcct gcctcagcct cccaagtagc   4560

tgggattaca ggcacccacc acctcaccca gctaattttt gtattttcag tagagacggg   4620

gtttcaccat gttggccagg ctactctcaa actcctgacc tcaggtgatc tgcccacctc   4680

ggcttcccaa agtgctggaa ttacaggcct gagccacccc acccggccta ttttcttaaa   4740

ggggaacaaa tgatcttgac aacatattat tccataaaac cagtttaggg cacaggccag   4800

ttcctgatta gaacacagga cctgtgggag ggactatcag agatgcaaaa attacttcaa   4860

gatgagttta ttgttttcat ttgtattgca aaagttagaa gtcattttac aaattaaaaa   4920

aacatttttt tcttggtagt ctttaaaaat taggggattg aaaggatcca ggatgggctt   4980

tgtgtgtgtg tctcagattc tcatttatta gtgagcacac ctgtgtatat atataaatca   5040

caaggagatc atcaagggaa aacattttgc atgtgtaaag cttcatgaag ttctctttaa   5100

aaaataccaa agcttgttta tttctgataa ttaacctaag cccttatgaa aataaacaaa   5160

atgaagggat tatgacaggt attaccaaaa acaccaaaag gaacaaaggg gcctgcgtta   5220

aaacctaatt gctaatgctt cacaactagg agagcatgcc gtcttgatgt ttaaaaaacc   5280

cagggtctcc acccttcctt tgatttgtgc aattctgtct tccacagttc cggagccttc   5340

agtgaggggt agctacatgc cccatgcctg ccctttcttt ccttctttgc tcactttact   5400

atgggtgtat tttaatcttg tataaaaata tgcatgaatg agtcatgcac atgtatacgt   5460

tatgtatttg acaagtggtg gtgaaacaaa atcaaaacag atttgatttg tgtttttgaa   5520

atgtcagtac attttgtgcc actaacactg tgatgtataa aagagctgtt tgaatgcctt   5580

ttaatgttgt gttttgtact ctggaatcat atggaaaaag tttgatttgt aatttcaata   5640

catattttaa atgtattgtg tcttacgtag tttgtccccc cctttagcag ggattccttt   5700

ttaaagctat tttggctgga atacaggtga cttttgtaaa aaaaaaaaaa aaaaa        5755


<210>  488
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  488

Met Thr Thr Thr Arg Tyr Arg Pro Thr Trp Asp Leu Ala Leu Asp Pro 
1               5                   10                  15      


Leu Val Ser Cys Lys Leu Cys Leu Gly Glu Tyr Pro Val Glu Gln Met 
            20                  25                  30          


Thr Thr Ile Ala Gln Cys Gln Cys Ile Phe Cys Thr Leu Cys Leu Lys 
        35                  40                  45              


Gln Tyr Val Glu Leu Leu Ile Lys Glu Gly Leu Glu Thr Ala Ile Ser 
    50                  55                  60                  


Cys Pro Asp Ala Ala Cys Pro Lys Gln Gly His Leu Gln Glu Asn Glu 
65                  70                  75                  80  


Ile Glu Cys Met Val Ala Ala Glu Ile Met Gln Arg Tyr Lys Lys Leu 
                85                  90                  95      


Gln Phe Glu Arg Glu Val Leu Phe Asp Pro Cys Arg Thr Trp Cys Pro 
            100                 105                 110         


Ala Ser Thr Cys Gln Ala Val Cys Gln Leu Gln Asp Val Gly Leu Gln 
        115                 120                 125             


Thr Pro Gln Pro Val Gln Cys Lys Ala Cys Arg Met Glu Phe Cys Ser 
    130                 135                 140                 


Thr Cys Lys Ala Ser Trp His Pro Gly Gln Gly Cys Pro Glu Thr Met 
145                 150                 155                 160 


Pro Ile Thr Phe Leu Pro Gly Glu Thr Ser Ala Ala Phe Lys Met Glu 
                165                 170                 175     


Glu Asp Asp Ala Pro Ile Lys Arg Cys Pro Lys Cys Lys Val Tyr Ile 
            180                 185                 190         


Glu Arg Asp Glu Gly Cys Ala Gln Met Met Cys Lys Asn Cys Lys His 
        195                 200                 205             


Ala Phe Cys Trp Tyr Cys Leu Glu Ser Leu Asp Asp Asp Phe Leu Leu 
    210                 215                 220                 


Ile His Tyr Asp Lys Gly Pro Cys Arg Asn Lys Leu Gly His Ser Arg 
225                 230                 235                 240 


Ala Ser Val Ile Trp His Arg Thr Gln Val Val Gly Ile Phe Ala Gly 
                245                 250                 255     


Phe Gly Leu Leu Leu Leu Val Ala Ser Pro Phe Leu Leu Leu Ala Thr 
            260                 265                 270         


Pro Phe Val Leu Cys Cys Lys Cys Lys Cys Ser Lys Gly Asp Asp Asp 
        275                 280                 285             


Pro Leu Pro Thr 
    290         


<210>  489
<211>  5063
<212>  DNA
<213>  Homosapiens

<400>  489
atggggctgc ggccaggcat tttcctcctg gagctgctgc tgcttctggg gcaagggacc     60

cctcagatcc atacctctcc tagaaagagt acattggaag ggcagctatg gccagagacc    120

ctgaagaatt ctccattccc atgcaaccca aataaattag gagtgaatat gccttctaaa    180

tcagttcact ctctgaagcc ttctgatatt aaatttgtgg cagccattgg caatctggaa    240

attcctccag acccagggac gggcgatctg gagaagcaag actggactga aaggccacag    300

caggtgtgca tgggagtgat gacagtcctt tcagacatca tcagatattt cagtccttct    360

gttccaatgc ctgtgtgcca cactggaaag agagtcatac cccacgatgg tgctgaagac    420

ttgtggattc aggctcaaga actggtgaga aacatgaaag agaacctgca acttgacttt    480

caatttgact ggaagctcat caatgtgttc ttcagtaatg caagccagtg ttacctgtgc    540

ccctctgctc aacagaatgg gcttgcggcg ggcggcgtgg atgagctgat gggggtgctg    600

gactacctgc agcaggaggt ccccagagca tttgtaaacc tggtggacct ctctgaggtt    660

gcagaggtct ctcgtcagta tcacggcact tggctcagcc ctgcaccaga gccctgtaat    720

tgctcagagg agaccacccg gctggccaag gtggtgatgc agtggtctta tcaggaagcc    780

tggaacagcc tcctggcctc cagcaggtac agtgagcagg agtccttcac cgtggttttc    840

cagcctttct tctatgagac caccccatct ctacactcgg aggacccccg actccaggat    900

tctaccacgc tggcctggca tctctggaat aggatgatgg agccagcagg agagaaagat    960

gagccattga gtgtaaaaca cgggaggcca atgaagtgtc cctctcagga gagcccctat   1020

ctgttcagct acagaaacag caactacctg accagactgc agaaacccca agacaagctt   1080

gaggtaagag aaggagcgga aatcagatgt cctgacaaag acccctccga tacggttccc   1140

acctcagttc ataggctgaa gccggctgac atcaacgtaa ttggagccct gggtgactct   1200

ctcacggcag gcaatggggc cgggtccaca cctgggaacg tcttggacgt cttgactcag   1260

taccgaggcc tgtcctggag cgtcggcgga gatgagaaca tcggcaccgt taccaccctg   1320

gcgaacatcc tccgggaatt caacccttcc ctgaagggct tctctgttgg cactgggaaa   1380

gaaaccagtc ctaatgcctt cttaaaccag gctgtggcag gaggccgagc tgaggatcta   1440

cctgtccagg ccaggaggct ggtggacctg atgaagaatg acacgaggat acactttcag   1500

gaagactgga agataataac cctgtttata ggcggcaatg acctctgtga tttctgcaat   1560

gatctggtcc actattctcc ccagaacttc acagacaaca ttggaaaggc cctggacatc   1620

ctccatgctg aggttcctcg ggcatttgtg aacctggtga cggtgcttga gatcgtcaac   1680

ctgagggagc tgtaccagga gaaaaaagtc tactgcccaa ggatgatcct caggtctctg   1740

tgtccctgtg tcctgaagtt tgatgataac tcaacagaac ttgctaccct catcgaattc   1800

aacaagaagt ttcaggagaa gacccaccaa ctgattgaga gtgggcgata tgacacaagg   1860

gaagatttta ctgtggttgt gcagccgttc tttgaaaacg tggacatgcc aaagacctcg   1920

gaaggattgc ctgacaactc tttcttcgct cctgactgtt tccacttcag cagcaagtct   1980

cactcccgag cagccagtgc tctctggaac aatatgctgg agcctgttgg ccagaagacg   2040

actcgtcata agtttgaaaa caagatcaat atcacatgtc cgaaccaggt ccagccgttt   2100

ctgaggacct acaagaacag catgcagggt catgggacct ggctgccatg cagggacaga   2160

gccccttctg ccttgcaccc tacctcagtg catgccctga gacctgcaga catccaagtt   2220

gtggctgctc tgggggattc tctgaccgct ggcaatggaa ttggctccaa accagacgac   2280

ctccccgatg tcaccacaca gtatcgggga ctgtcataca gtgcaggagg ggacggctcc   2340

ctggagaatg tgaccacctt acctaatatc cttcgggagt ttaacagaaa cctcacaggc   2400

tacgccgtgg gcacgggtga tgccaatgac acgaatgcat tcctcaatca agctgttccc   2460

ggagcaaagg ctgaggatct tatgagccaa gtccaaactc tgatgcagaa gatgaaagat   2520

gatcatagag taaatttcca tgaagactgg aaggtcatca cagtgctgat cggaggcagc   2580

gatttatgtg actactgcac agattcgaat ctgtattctg cagccaactt tgttgaccat   2640

ctccgcaatg ccttggacgt cctgcataga gaggtgccca gagtcctggt caacctcgtg   2700

gacttcctga accccactat catgcggcag gtgttcctgg gaaacccaga caagtgccca   2760

gtgcagcagg ccagcgtttt gtgtaactgc gttctgaccc tgcgggagaa ctcccaagag   2820

ctagccaggc tggaggcctt cagccgagcc taccggagca gcatgcgcga gctggtgggg   2880

tcaggccgct atgacacgca ggaggacttc tctgtggtgc tgcagccctt cttccagaac   2940

atccagctcc ctgtcctggc ggatgggctc ccagatacgt ccttctttgc cccagactgc   3000

atccacccaa atcagaaatt ccactcccag ctggccagag ccctttggac caatatgctt   3060

gaaccacttg gaagcaaaac agagaccctg gacctgagag cagagatgcc catcacctgt   3120

cccactcaga atgagccctt cctgagaacc cctcggaata gtaactacac gtaccccatc   3180

aagccagcca ttgagaactg gggcagtgac ttcctgtgta cagagtggaa ggcttccaat   3240

agtgttccaa cctctgtcca ccagctccga ccagcagaca tcaaagtggt ggccgccctg   3300

ggtgactctc tgactacagc agtgggagct cgaccaaaca actccagtga cctacccaca   3360

tcttggaggg gactctcttg gagcattgga ggggatggga acttggagac tcacaccaca   3420

ctgcccaaca ttctgaagaa gttcaaccct tacctccttg gcttctctac cagcacctgg   3480

gaggggacag caggactaaa tgtggcagcg gaaggggcca gagctaggga catgccagcc   3540

caggcctggg acctggtaga gcgaatgaaa aacagccccg acatcaacct ggagaaagac   3600

tggaagctgg tcacactctt cattggggtc aacgacttgt gtcattactg tgagaatccg   3660

gaggcccact tggccacgga atatgttcag cacatccaac aggccctgga catcctctct   3720

gaggagctcc caagggcttt cgtcaacgtg gtggaggtca tggagctggc tagcctgtac   3780

cagggccaag gcgggaaatg tgccatgctg gcagctcaga acaactgcac ttgcctcaga   3840

cactcgcaaa gctccctgga gaagcaagaa ctgaagaaag tgaactggaa cctccagcat   3900

ggcatctcca gtttctccta ctggcaccaa tacacacagc gtgaggactt tgcggttgtg   3960

gtgcagcctt tcttccaaaa cacactcacc ccactgaacg agagagggga cactgacctc   4020

accttcttct ccgaggactg ttttcacttc tcagaccgcg ggcatgccga gatggccatc   4080

gcactctgga acaacatgct ggaaccagtg ggccgcaaga ctacctccaa caacttcacc   4140

cacagccgag ccaaactcaa gtgcccctct cctgagagcc cttacctcta caccctgcgg   4200

aacagccgat tgctcccaga ccaggctgaa gaagcccccg aggtgctcta ctgggctgtc   4260

ccagtggcag cgggagtcgg ccttgtggtg ggcatcatcg ggacagtggt ctggaggtgc   4320

aggagaggtg gccggaggga agatcctcca atgagcctgc gcactgtggc cctctaggcc   4380

cgggggtggg tcctcaccct aaactcccta tagccactct cttcaccgcc ctctgcccca   4440

gccactcccg gccaccagga catgcttcaa tgcctggtgc cataggaagc ccaggggaca   4500

gtcacaactt cttggggcct gggcttcttc caggcctatg ctcctggaat ggatacattt   4560

aaataaagtc caaagctatt ttattcctgg gtttgcctgc gtgaagcact caccttccat   4620

ctcttgtgca gcccaggtgt gggagctgcc actttttgtg gcctgcctcc agcagggctg   4680

cccaagccac gaccaaccag agcccaaact gcctgccacc acgagcatat cctcaagtca   4740

ccaaacccac tatttcaaag gcagaaaaaa tgctggtcac caggtggtgg ctggaatttt   4800

ggagctggct ggttgccatt cagtccaatc caacacatac ctattaagca actgttttgt   4860

atccaggaca atgcgaagca ctgaggtgcc tcctaggctg tgcatgtcgc agcctggcag   4920

agaggtcaaa ctccttcaat aaccaagaag ccacgtgatg atgtgtaact actagggcat   4980

cagtaggtaa atgtgtctga ttgttttaaa gaatagaaag ggttcttcgg ggaaagtttc   5040

ttgggggaga gcaaccttca cat                                           5063


<210>  490
<211>  1458
<212>  PRT
<213>  Homosapiens

<400>  490

Met Gly Leu Arg Pro Gly Ile Phe Leu Leu Glu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Gln Gly Thr Pro Gln Ile His Thr Ser Pro Arg Lys Ser Thr Leu 
            20                  25                  30          


Glu Gly Gln Leu Trp Pro Glu Thr Leu Lys Asn Ser Pro Phe Pro Cys 
        35                  40                  45              


Asn Pro Asn Lys Leu Gly Val Asn Met Pro Ser Lys Ser Val His Ser 
    50                  55                  60                  


Leu Lys Pro Ser Asp Ile Lys Phe Val Ala Ala Ile Gly Asn Leu Glu 
65                  70                  75                  80  


Ile Pro Pro Asp Pro Gly Thr Gly Asp Leu Glu Lys Gln Asp Trp Thr 
                85                  90                  95      


Glu Arg Pro Gln Gln Val Cys Met Gly Val Met Thr Val Leu Ser Asp 
            100                 105                 110         


Ile Ile Arg Tyr Phe Ser Pro Ser Val Pro Met Pro Val Cys His Thr 
        115                 120                 125             


Gly Lys Arg Val Ile Pro His Asp Gly Ala Glu Asp Leu Trp Ile Gln 
    130                 135                 140                 


Ala Gln Glu Leu Val Arg Asn Met Lys Glu Asn Leu Gln Leu Asp Phe 
145                 150                 155                 160 


Gln Phe Asp Trp Lys Leu Ile Asn Val Phe Phe Ser Asn Ala Ser Gln 
                165                 170                 175     


Cys Tyr Leu Cys Pro Ser Ala Gln Gln Asn Gly Leu Ala Ala Gly Gly 
            180                 185                 190         


Val Asp Glu Leu Met Gly Val Leu Asp Tyr Leu Gln Gln Glu Val Pro 
        195                 200                 205             


Arg Ala Phe Val Asn Leu Val Asp Leu Ser Glu Val Ala Glu Val Ser 
    210                 215                 220                 


Arg Gln Tyr His Gly Thr Trp Leu Ser Pro Ala Pro Glu Pro Cys Asn 
225                 230                 235                 240 


Cys Ser Glu Glu Thr Thr Arg Leu Ala Lys Val Val Met Gln Trp Ser 
                245                 250                 255     


Tyr Gln Glu Ala Trp Asn Ser Leu Leu Ala Ser Ser Arg Tyr Ser Glu 
            260                 265                 270         


Gln Glu Ser Phe Thr Val Val Phe Gln Pro Phe Phe Tyr Glu Thr Thr 
        275                 280                 285             


Pro Ser Leu His Ser Glu Asp Pro Arg Leu Gln Asp Ser Thr Thr Leu 
    290                 295                 300                 


Ala Trp His Leu Trp Asn Arg Met Met Glu Pro Ala Gly Glu Lys Asp 
305                 310                 315                 320 


Glu Pro Leu Ser Val Lys His Gly Arg Pro Met Lys Cys Pro Ser Gln 
                325                 330                 335     


Glu Ser Pro Tyr Leu Phe Ser Tyr Arg Asn Ser Asn Tyr Leu Thr Arg 
            340                 345                 350         


Leu Gln Lys Pro Gln Asp Lys Leu Glu Val Arg Glu Gly Ala Glu Ile 
        355                 360                 365             


Arg Cys Pro Asp Lys Asp Pro Ser Asp Thr Val Pro Thr Ser Val His 
    370                 375                 380                 


Arg Leu Lys Pro Ala Asp Ile Asn Val Ile Gly Ala Leu Gly Asp Ser 
385                 390                 395                 400 


Leu Thr Ala Gly Asn Gly Ala Gly Ser Thr Pro Gly Asn Val Leu Asp 
                405                 410                 415     


Val Leu Thr Gln Tyr Arg Gly Leu Ser Trp Ser Val Gly Gly Asp Glu 
            420                 425                 430         


Asn Ile Gly Thr Val Thr Thr Leu Ala Asn Ile Leu Arg Glu Phe Asn 
        435                 440                 445             


Pro Ser Leu Lys Gly Phe Ser Val Gly Thr Gly Lys Glu Thr Ser Pro 
    450                 455                 460                 


Asn Ala Phe Leu Asn Gln Ala Val Ala Gly Gly Arg Ala Glu Asp Leu 
465                 470                 475                 480 


Pro Val Gln Ala Arg Arg Leu Val Asp Leu Met Lys Asn Asp Thr Arg 
                485                 490                 495     


Ile His Phe Gln Glu Asp Trp Lys Ile Ile Thr Leu Phe Ile Gly Gly 
            500                 505                 510         


Asn Asp Leu Cys Asp Phe Cys Asn Asp Leu Val His Tyr Ser Pro Gln 
        515                 520                 525             


Asn Phe Thr Asp Asn Ile Gly Lys Ala Leu Asp Ile Leu His Ala Glu 
    530                 535                 540                 


Val Pro Arg Ala Phe Val Asn Leu Val Thr Val Leu Glu Ile Val Asn 
545                 550                 555                 560 


Leu Arg Glu Leu Tyr Gln Glu Lys Lys Val Tyr Cys Pro Arg Met Ile 
                565                 570                 575     


Leu Arg Ser Leu Cys Pro Cys Val Leu Lys Phe Asp Asp Asn Ser Thr 
            580                 585                 590         


Glu Leu Ala Thr Leu Ile Glu Phe Asn Lys Lys Phe Gln Glu Lys Thr 
        595                 600                 605             


His Gln Leu Ile Glu Ser Gly Arg Tyr Asp Thr Arg Glu Asp Phe Thr 
    610                 615                 620                 


Val Val Val Gln Pro Phe Phe Glu Asn Val Asp Met Pro Lys Thr Ser 
625                 630                 635                 640 


Glu Gly Leu Pro Asp Asn Ser Phe Phe Ala Pro Asp Cys Phe His Phe 
                645                 650                 655     


Ser Ser Lys Ser His Ser Arg Ala Ala Ser Ala Leu Trp Asn Asn Met 
            660                 665                 670         


Leu Glu Pro Val Gly Gln Lys Thr Thr Arg His Lys Phe Glu Asn Lys 
        675                 680                 685             


Ile Asn Ile Thr Cys Pro Asn Gln Val Gln Pro Phe Leu Arg Thr Tyr 
    690                 695                 700                 


Lys Asn Ser Met Gln Gly His Gly Thr Trp Leu Pro Cys Arg Asp Arg 
705                 710                 715                 720 


Ala Pro Ser Ala Leu His Pro Thr Ser Val His Ala Leu Arg Pro Ala 
                725                 730                 735     


Asp Ile Gln Val Val Ala Ala Leu Gly Asp Ser Leu Thr Ala Gly Asn 
            740                 745                 750         


Gly Ile Gly Ser Lys Pro Asp Asp Leu Pro Asp Val Thr Thr Gln Tyr 
        755                 760                 765             


Arg Gly Leu Ser Tyr Ser Ala Gly Gly Asp Gly Ser Leu Glu Asn Val 
    770                 775                 780                 


Thr Thr Leu Pro Asn Ile Leu Arg Glu Phe Asn Arg Asn Leu Thr Gly 
785                 790                 795                 800 


Tyr Ala Val Gly Thr Gly Asp Ala Asn Asp Thr Asn Ala Phe Leu Asn 
                805                 810                 815     


Gln Ala Val Pro Gly Ala Lys Ala Glu Asp Leu Met Ser Gln Val Gln 
            820                 825                 830         


Thr Leu Met Gln Lys Met Lys Asp Asp His Arg Val Asn Phe His Glu 
        835                 840                 845             


Asp Trp Lys Val Ile Thr Val Leu Ile Gly Gly Ser Asp Leu Cys Asp 
    850                 855                 860                 


Tyr Cys Thr Asp Ser Asn Leu Tyr Ser Ala Ala Asn Phe Val Asp His 
865                 870                 875                 880 


Leu Arg Asn Ala Leu Asp Val Leu His Arg Glu Val Pro Arg Val Leu 
                885                 890                 895     


Val Asn Leu Val Asp Phe Leu Asn Pro Thr Ile Met Arg Gln Val Phe 
            900                 905                 910         


Leu Gly Asn Pro Asp Lys Cys Pro Val Gln Gln Ala Ser Val Leu Cys 
        915                 920                 925             


Asn Cys Val Leu Thr Leu Arg Glu Asn Ser Gln Glu Leu Ala Arg Leu 
    930                 935                 940                 


Glu Ala Phe Ser Arg Ala Tyr Arg Ser Ser Met Arg Glu Leu Val Gly 
945                 950                 955                 960 


Ser Gly Arg Tyr Asp Thr Gln Glu Asp Phe Ser Val Val Leu Gln Pro 
                965                 970                 975     


Phe Phe Gln Asn Ile Gln Leu Pro Val Leu Ala Asp Gly Leu Pro Asp 
            980                 985                 990         


Thr Ser Phe Phe Ala Pro Asp Cys  Ile His Pro Asn Gln  Lys Phe His 
        995                 1000                 1005             


Ser Gln  Leu Ala Arg Ala Leu  Trp Thr Asn Met Leu  Glu Pro Leu 
    1010                 1015                 1020             


Gly Ser  Lys Thr Glu Thr Leu  Asp Leu Arg Ala Glu  Met Pro Ile 
    1025                 1030                 1035             


Thr Cys  Pro Thr Gln Asn Glu  Pro Phe Leu Arg Thr  Pro Arg Asn 
    1040                 1045                 1050             


Ser Asn  Tyr Thr Tyr Pro Ile  Lys Pro Ala Ile Glu  Asn Trp Gly 
    1055                 1060                 1065             


Ser Asp  Phe Leu Cys Thr Glu  Trp Lys Ala Ser Asn  Ser Val Pro 
    1070                 1075                 1080             


Thr Ser  Val His Gln Leu Arg  Pro Ala Asp Ile Lys  Val Val Ala 
    1085                 1090                 1095             


Ala Leu  Gly Asp Ser Leu Thr  Thr Ala Val Gly Ala  Arg Pro Asn 
    1100                 1105                 1110             


Asn Ser  Ser Asp Leu Pro Thr  Ser Trp Arg Gly Leu  Ser Trp Ser 
    1115                 1120                 1125             


Ile Gly  Gly Asp Gly Asn Leu  Glu Thr His Thr Thr  Leu Pro Asn 
    1130                 1135                 1140             


Ile Leu  Lys Lys Phe Asn Pro  Tyr Leu Leu Gly Phe  Ser Thr Ser 
    1145                 1150                 1155             


Thr Trp  Glu Gly Thr Ala Gly  Leu Asn Val Ala Ala  Glu Gly Ala 
    1160                 1165                 1170             


Arg Ala  Arg Asp Met Pro Ala  Gln Ala Trp Asp Leu  Val Glu Arg 
    1175                 1180                 1185             


Met Lys  Asn Ser Pro Asp Ile  Asn Leu Glu Lys Asp  Trp Lys Leu 
    1190                 1195                 1200             


Val Thr  Leu Phe Ile Gly Val  Asn Asp Leu Cys His  Tyr Cys Glu 
    1205                 1210                 1215             


Asn Pro  Glu Ala His Leu Ala  Thr Glu Tyr Val Gln  His Ile Gln 
    1220                 1225                 1230             


Gln Ala  Leu Asp Ile Leu Ser  Glu Glu Leu Pro Arg  Ala Phe Val 
    1235                 1240                 1245             


Asn Val  Val Glu Val Met Glu  Leu Ala Ser Leu Tyr  Gln Gly Gln 
    1250                 1255                 1260             


Gly Gly  Lys Cys Ala Met Leu  Ala Ala Gln Asn Asn  Cys Thr Cys 
    1265                 1270                 1275             


Leu Arg  His Ser Gln Ser Ser  Leu Glu Lys Gln Glu  Leu Lys Lys 
    1280                 1285                 1290             


Val Asn  Trp Asn Leu Gln His  Gly Ile Ser Ser Phe  Ser Tyr Trp 
    1295                 1300                 1305             


His Gln  Tyr Thr Gln Arg Glu  Asp Phe Ala Val Val  Val Gln Pro 
    1310                 1315                 1320             


Phe Phe  Gln Asn Thr Leu Thr  Pro Leu Asn Glu Arg  Gly Asp Thr 
    1325                 1330                 1335             


Asp Leu  Thr Phe Phe Ser Glu  Asp Cys Phe His Phe  Ser Asp Arg 
    1340                 1345                 1350             


Gly His  Ala Glu Met Ala Ile  Ala Leu Trp Asn Asn  Met Leu Glu 
    1355                 1360                 1365             


Pro Val  Gly Arg Lys Thr Thr  Ser Asn Asn Phe Thr  His Ser Arg 
    1370                 1375                 1380             


Ala Lys  Leu Lys Cys Pro Ser  Pro Glu Ser Pro Tyr  Leu Tyr Thr 
    1385                 1390                 1395             


Leu Arg  Asn Ser Arg Leu Leu  Pro Asp Gln Ala Glu  Glu Ala Pro 
    1400                 1405                 1410             


Glu Val  Leu Tyr Trp Ala Val  Pro Val Ala Ala Gly  Val Gly Leu 
    1415                 1420                 1425             


Val Val  Gly Ile Ile Gly Thr  Val Val Trp Arg Cys  Arg Arg Gly 
    1430                 1435                 1440             


Gly Arg  Arg Glu Asp Pro Pro  Met Ser Leu Arg Thr  Val Ala Leu 
    1445                 1450                 1455             


<210>  491
<211>  4991
<212>  DNA
<213>  Homosapiens

<400>  491
ggcggcgcgc aagggacgtg cggagtgagt ggcgctgcgg gtggggccgt cggcggcgct     60

ggtgagcttt gcggagctgg gcggtgccga ggaggaggag gtggcggcct gggtctgacg    120

cggccctgtt cgagggggcc tctcttgttt atttatttat tttccgtggg tgcctccgag    180

tgtgcgcgcg ctctcgctac ccggcgggga gggggtgggg ggagggcccg ggaaaagggg    240

gagttggagc cggggtcgaa acgccgcgtg acttgtaggt gagagaacgc cgagccgtcg    300

ccgcagcctc cgccgccgag aagcccttgt tcccgctgct gggaaggaga gtctgtgccg    360

acaagatggc ggacggggag ctgaacgtgg acagcctcat cacccggctg ctggaggtac    420

gaggatgtcg tccaggaaag attgtgcaga tgactgaagc agaagttcga ggcttatgta    480

tcaagtctcg ggagatcttt ctcagccagc ctattctttt ggaattggaa gcaccgctga    540

aaatttgtgg agatattcat ggacaatata cagatttact gagattattt gaatatggag    600

gtttcccacc agaagccaac tatcttttct taggagatta tgtggacaga ggaaagcagt    660

ctttggaaac catttgtttg ctattggctt ataaaatcaa atatccagag aacttctttc    720

tcttaagagg aaaccatgag tgtgctagca tcaatcgcat ttatggattc tatgatgaat    780

gcaaacgaag atttaatatt aaattgtgga agaccttcac tgattgtttt aactgtctgc    840

ctatagcagc cattgtggat gagaagatct tctgttgtca tggaggattg tcaccagacc    900

tgcaatctat ggagcagatt cggagaatta tgagacctac tgatgtccct gatacaggtt    960

tgctctgtga tttgctatgg tctgatccag ataaggatgt gcaaggctgg ggagaaaatg   1020

atcgtggtgt ttcctttact tttggagctg atgtagtcag taaatttctg aatcgtcatg   1080

atttagattt gatttgtcga gctcatcagg tggtggaaga tggatatgaa ttttttgcta   1140

aacgacagtt ggtaacctta ttttcagccc caaattactg tggcgagttt gataatgctg   1200

gtggaatgat gagtgtggat gaaactttga tgtgttcatt tcagatattg aaaccatctg   1260

aaaagaaagc taaataccag tatggtggac tgaattctgg acgtcctgtc actccacctc   1320

gaacagctaa tccgccgaag aaaaggtgaa gaaaggaatt ctgtaaagaa accatcagat   1380

ttgttaagga catacttcat aatatataag tgtgcactgt aaaaccatcc agccatttga   1440

caccctttat gatgtcacac ctttaactta aggagacggg taaaggatct taaatttttt   1500

tctaatagaa agatgtgcta cactgtattg taataagtat actctgttat agtcaacaaa   1560

gttaaatcca aattcaaaat tatccattaa agttacatct tcatgtatca caatttttaa   1620

agttgaaaag catcccagtt aaactagatg tgatagttaa accagatgaa agcatgatga   1680

tccatctgtg taatgtggtt ttagtgttgc ttggttgttt aattattttg agcttgtttt   1740

gtttttgttt gttttcacta gaataatggc aaatacttct aatttttttc cctaaacatt   1800

tttaaaagtg aaatatggga agagctttac agacattcac caactattat tttcccttgt   1860

ttatctactt agatatctgt ttaatcttac taagaaaact ttcgcctcat tacattaaaa   1920

aggaatttta gagattgatt gttttaaaaa aaaatacgca cattgtccaa tccagtgatt   1980

ttaatcatac agtttgactg ggcaaacttt acagctgata gtgaatattt tgctttatac   2040

aggaattgac actgatttgg atttgtgcac tctaattttt aacttattga tgctctattg   2100

tgcagtagca tttcatttaa gataaggctc atatagtatt acccaactag ttggtaatgt   2160

gattatgtgg taccttggct ttaggttttc attcgcacgg aacacctttt ggcatgctta   2220

acttcctggt aacaccttca cctgcattgg ttttcttttt cttttttctt tctttttttt   2280

tttttttttt tttttgagtt gttgtttgtt tttagatcca cagtacatga gaatcctttt   2340

ttgacaagcc ttggaaagct gacactgtct ctttttcctc cctctatacg aaggatgtat   2400

ttaaatgaat gctggtcagt gggacatttt gtcaactatg ggtattgggt gcttaactgt   2460

ctaatattgc catgtgaatg ttgtatacga ttgtaaggct tatgtcacta aagattttta   2520

ttctgatttt ttcataatca aaggtcatat gatactgtat agacaagctt tgtagtgaag   2580

tatagtagca ataatttctg tacctgatca agtttattgc agcctttctt ttcctatttc   2640

ttttttttaa gggttagtat taacaaatgg caatgagtag aaaagttaac atgaagattt   2700

tagaaggaga gaacttacag gacacagatt tgtgattctt tgactgtgac actattggat   2760

gtgattctaa aagcttttat tgagcattgt caaatttgta agcttcatag ggatggacat   2820

catatctata atgcccttct atatgtgcta ccatagatgt gacatttttg accttaatat   2880

cgtctttgaa aatgttaaat tgagaaacct gttaacttac attttatgaa ttggcacatt   2940

gtattactta ctgcaagaga tatttcattt tcagcacagt gcaaaagttc tttaaaatgc   3000

atatgtcttt ttttctaatt ccgttttgtt ttaaagcaca ttttaaatgt agttttctca   3060

tttagtaaaa gttgtctaat tgatatgaag cctgactgat tttttttttc cttacagtga   3120

gacatttaag cacacatttt attcacatag atactatgtc cttgacatat tgaaatgatt   3180

cttttctgaa agtattcatg atctgcatat gatgtattag gttaggtcac aaaggtttta   3240

tctgaggtga tttaaataac ttcctgattg gagtgtgtaa gctgagcgat ttctaataaa   3300

attttagttg tacactttta gtagtcatag tgaagcaggt ctagaaaata agcctttggc   3360

agggaaaaag ggcaatgttg attaatctca gtattaaacc acattaatct gtatcccatt   3420

gtctggcttt tgtaaattca tccaggtcaa gactaagtat gttggttaat aggaatcctt   3480

tttttttttt ttaaagacta aatgtgaaaa aataatcact acttaagcta attaatattg   3540

gtcattaaat ttaaaggatg gaaatttatc atgtttaaaa attattcaag cactcttaaa   3600

accacttaaa cagcctccag tcataaaaat gtgttcttta caaatatttg cttggcaaca   3660

cgacttgaaa taaataaaac tttgtttctt aggagaaaat gattctgtaa ttccagtgtc   3720

actaatttat attgttcttt cctctgattt ttttcaggtt agtgattttt ttgtatacaa   3780

tttaatccaa atgttatgac attcagaaat catgaaacac agtagatatc tgttataatg   3840

tggtgtatca catggattat aaagcaaagt tatggtcgat ttctattctt gaaagaatca   3900

actacagtga atcctttgca tttgaagcct taacatgcat tgctttaatt ttgcccaggg   3960

acaaatttta ataatcagca agactggttt gtgcaaagcg ttgagtcatc aggtatttag   4020

agcctagcca gctacccagt atccatgctg ccatatccct tcattgtaaa aagtacctaa   4080

acattcgtga aatgattttt tttagctgaa aaatgctggc aagaagaatt ttaaagctta   4140

aaataggtgg taaatttgaa gtatgagtgt gttcacgaga aacataggct tttcaaaaaa   4200

atttttattc aaggcaaagc aaggaacatc ttgagatatg tctcaagaat ataaagatgt   4260

attattttaa gccaaggagc tgaaatatat ctcagtttat aaattcaggt atattctttt   4320

tgtctccatg gcaaccataa cttttgaacc aaaaaaaatt gtttttacat ctttatgctg   4380

aaaatgtgtt tagattagga atatggtcgg gctgaatttg ctgttgctcc ctaaccaaat   4440

ccacctcttg ttttccttgt gagtccatgg ctaaatcaaa gctgcccctg agaagagact   4500

taatccaagc ctgattgtac tagtggcatc acttagaagt aggctttccc tcttcctagt   4560

agatctcaat gttttataat tccttaaaac agctgaaaat tgggacaaca tactttacgc   4620

aatgaacagt agttaaatag gaaataaact agttccatat aagtatacac ctagagtttt   4680

aattaccttt ataatgtttc ttaaaagtga aacttagata caattgtgat tggatactta   4740

gatactaagt gaaacttagt gtaacaattt tgatctgtta aattggattt tacatgtaca   4800

tttgaatgcc agaatttcta aataaatccc ctggttagga aattttaaaa gtcaaagctt   4860

gttttcttca accactacct tctacattgg ttgacttaga ccgtaagctt tttaagtttc   4920

tcattgtaat ttaccttctc atgcagattg ctgatgtttt attaaacctt atttttacaa   4980

aaatgaaaaa a                                                        4991


<210>  492
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  492

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                165                 170                 175     


Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
            180                 185                 190         


Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
        195                 200                 205             


Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
    210                 215                 220                 


Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
    290                 295                 300                 


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
305                 310                 315                 320 


Ala Asn Pro Pro Lys Lys Arg 
                325         


<210>  493
<211>  4786
<212>  DNA
<213>  Homosapiens

<400>  493
gctgcgtgac gcggcggcgc gcaagggacg tgcggagtga gtggcgctgc gggtggggcc     60

gtcggcggcg ctggtgagag aacgccgagc cgtcgccgca gcctccgccg ccgagaagcc    120

cttgttcccg ctgctgggaa ggagagtctg tgccgacaag atggcggacg gggagctgaa    180

cgtggacagc ctcatcaccc ggctgctgga ggtacgagga tgtcgtccag gaaagattgt    240

gcagatgact gaagcagaag ttcgaggctt atgtatcaag tctcgggaga tctttctcag    300

ccagcctatt cttttggaat tggaagcacc gctgaaaatt tgtggagata ttcatggaca    360

atatacagat ttactgagat tatttgaata tggaggtttc ccaccagaag ccaactatct    420

tttcttagga gattatgtgg acagaggaaa gcagtctttg gaaaccattt gtttgctatt    480

ggcttataaa atcaaatatc cagagaactt ctttctctta agaggaaacc atgagtgtgc    540

tagcatcaat cgcatttatg gattctatga tgaatgcaaa cgaagattta atattaaatt    600

gtggaagacc ttcactgatt gttttaactg tctgcctata gcagccattg tggatgagaa    660

gatcttctgt tgtcatggag gattgtcacc agacctgcaa tctatggagc agattcggag    720

aattatgaga cctactgatg tccctgatac aggtttgctc tgtgatttgc tatggtctga    780

tccagataag gatgtgcaag gctggggaga aaatgatcgt ggtgtttcct ttacttttgg    840

agctgatgta gtcagtaaat ttctgaatcg tcatgattta gatttgattt gtcgagctca    900

tcaggtggtg gaagatggat atgaattttt tgctaaacga cagttggtaa ccttattttc    960

agccccaaat tactgtggcg agtttgataa tgctggtgga atgatgagtg tggatgaaac   1020

tttgatgtgt tcatttcaga tattgaaacc atctgaaaag aaagctaaat accagtatgg   1080

tggactgaat tctggacgtc ctgtcactcc acctcgaaca gctaatccgc cgaagaaaag   1140

gtgaagaaag gaattctgta aagaaaccat cagatttgtt aaggacatac ttcataatat   1200

ataagtgtgc actgtaaaac catccagcca tttgacaccc tttatgatgt cacaccttta   1260

acttaaggag acgggtaaag gatcttaaat ttttttctaa tagaaagatg tgctacactg   1320

tattgtaata agtatactct gttatagtca acaaagttaa atccaaattc aaaattatcc   1380

attaaagtta catcttcatg tatcacaatt tttaaagttg aaaagcatcc cagttaaact   1440

agatgtgata gttaaaccag atgaaagcat gatgatccat ctgtgtaatg tggttttagt   1500

gttgcttggt tgtttaatta ttttgagctt gttttgtttt tgtttgtttt cactagaata   1560

atggcaaata cttctaattt ttttccctaa acatttttaa aagtgaaata tgggaagagc   1620

tttacagaca ttcaccaact attattttcc cttgtttatc tacttagata tctgtttaat   1680

cttactaaga aaactttcgc ctcattacat taaaaaggaa ttttagagat tgattgtttt   1740

aaaaaaaaat acgcacattg tccaatccag tgattttaat catacagttt gactgggcaa   1800

actttacagc tgatagtgaa tattttgctt tatacaggaa ttgacactga tttggatttg   1860

tgcactctaa tttttaactt attgatgctc tattgtgcag tagcatttca tttaagataa   1920

ggctcatata gtattaccca actagttggt aatgtgatta tgtggtacct tggctttagg   1980

ttttcattcg cacggaacac cttttggcat gcttaacttc ctggtaacac cttcacctgc   2040

attggttttc tttttctttt ttctttcttt tttttttttt tttttttttt gagttgttgt   2100

ttgtttttag atccacagta catgagaatc cttttttgac aagccttgga aagctgacac   2160

tgtctctttt tcctccctct atacgaagga tgtatttaaa tgaatgctgg tcagtgggac   2220

attttgtcaa ctatgggtat tgggtgctta actgtctaat attgccatgt gaatgttgta   2280

tacgattgta aggcttatgt cactaaagat ttttattctg attttttcat aatcaaaggt   2340

catatgatac tgtatagaca agctttgtag tgaagtatag tagcaataat ttctgtacct   2400

gatcaagttt attgcagcct ttcttttcct atttcttttt tttaagggtt agtattaaca   2460

aatggcaatg agtagaaaag ttaacatgaa gattttagaa ggagagaact tacaggacac   2520

agatttgtga ttctttgact gtgacactat tggatgtgat tctaaaagct tttattgagc   2580

attgtcaaat ttgtaagctt catagggatg gacatcatat ctataatgcc cttctatatg   2640

tgctaccata gatgtgacat ttttgacctt aatatcgtct ttgaaaatgt taaattgaga   2700

aacctgttaa cttacatttt atgaattggc acattgtatt acttactgca agagatattt   2760

cattttcagc acagtgcaaa agttctttaa aatgcatatg tctttttttc taattccgtt   2820

ttgttttaaa gcacatttta aatgtagttt tctcatttag taaaagttgt ctaattgata   2880

tgaagcctga ctgatttttt ttttccttac agtgagacat ttaagcacac attttattca   2940

catagatact atgtccttga catattgaaa tgattctttt ctgaaagtat tcatgatctg   3000

catatgatgt attaggttag gtcacaaagg ttttatctga ggtgatttaa ataacttcct   3060

gattggagtg tgtaagctga gcgatttcta ataaaatttt agttgtacac ttttagtagt   3120

catagtgaag caggtctaga aaataagcct ttggcaggga aaaagggcaa tgttgattaa   3180

tctcagtatt aaaccacatt aatctgtatc ccattgtctg gcttttgtaa attcatccag   3240

gtcaagacta agtatgttgg ttaataggaa tccttttttt tttttttaaa gactaaatgt   3300

gaaaaaataa tcactactta agctaattaa tattggtcat taaatttaaa ggatggaaat   3360

ttatcatgtt taaaaattat tcaagcactc ttaaaaccac ttaaacagcc tccagtcata   3420

aaaatgtgtt ctttacaaat atttgcttgg caacacgact tgaaataaat aaaactttgt   3480

ttcttaggag aaaatgattc tgtaattcca gtgtcactaa tttatattgt tctttcctct   3540

gatttttttc aggttagtga tttttttgta tacaatttaa tccaaatgtt atgacattca   3600

gaaatcatga aacacagtag atatctgtta taatgtggtg tatcacatgg attataaagc   3660

aaagttatgg tcgatttcta ttcttgaaag aatcaactac agtgaatcct ttgcatttga   3720

agccttaaca tgcattgctt taattttgcc cagggacaaa ttttaataat cagcaagact   3780

ggtttgtgca aagcgttgag tcatcaggta tttagagcct agccagctac ccagtatcca   3840

tgctgccata tcccttcatt gtaaaaagta cctaaacatt cgtgaaatga ttttttttag   3900

ctgaaaaatg ctggcaagaa gaattttaaa gcttaaaata ggtggtaaat ttgaagtatg   3960

agtgtgttca cgagaaacat aggcttttca aaaaaatttt tattcaaggc aaagcaagga   4020

acatcttgag atatgtctca agaatataaa gatgtattat tttaagccaa ggagctgaaa   4080

tatatctcag tttataaatt caggtatatt ctttttgtct ccatggcaac cataactttt   4140

gaaccaaaaa aaattgtttt tacatcttta tgctgaaaat gtgtttagat taggaatatg   4200

gtcgggctga atttgctgtt gctccctaac caaatccacc tcttgttttc cttgtgagtc   4260

catggctaaa tcaaagctgc ccctgagaag agacttaatc caagcctgat tgtactagtg   4320

gcatcactta gaagtaggct ttccctcttc ctagtagatc tcaatgtttt ataattcctt   4380

aaaacagctg aaaattggga caacatactt tacgcaatga acagtagtta aataggaaat   4440

aaactagttc catataagta tacacctaga gttttaatta cctttataat gtttcttaaa   4500

agtgaaactt agatacaatt gtgattggat acttagatac taagtgaaac ttagtgtaac   4560

aattttgatc tgttaaattg gattttacat gtacatttga atgccagaat ttctaaataa   4620

atcccctggt taggaaattt taaaagtcaa agcttgtttt cttcaaccac taccttctac   4680

attggttgac ttagaccgta agctttttaa gtttctcatt gtaatttacc ttctcatgca   4740

gattgctgat gttttattaa accttatttt tacaaaaatg aaaaaa                  4786


<210>  494
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  494

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                165                 170                 175     


Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
            180                 185                 190         


Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
        195                 200                 205             


Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
    210                 215                 220                 


Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
    290                 295                 300                 


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
305                 310                 315                 320 


Ala Asn Pro Pro Lys Lys Arg 
                325         


<210>  495
<211>  4288
<212>  DNA
<213>  Homosapiens

<400>  495
gctgcgtgac gcggcggcgc gcaagggacg tgcggagtga gtggcgctgc gggtggggcc     60

gtcggcggcg ctggtgagct ttgcggagct gggcggtgcc gaggaggagg aggtggcggc    120

ctgggtctga cgcggccctg ttcgaggggg cctctcttgt ttatttattt attttccgtg    180

ggtgcctccg agtgtgcgcg cgctctcgct acccggcggg gagggggtgg ggggagggcc    240

cgggaaaagg gggagttgga gccggggtcg aaacgccgcg tgacttgtag gtgagagaac    300

gccgagccgt cgccgcagcc tccgccgccg agaagccctt gttcccgctg ctgggaagga    360

gagtctgtgc cgacaagatg gcggacgggg agctgaacgt ggacagcctc atcacccggc    420

tgctggagca gccattgtgg atgagaagat cttctgttgt catggaggat tgtcaccaga    480

cctgcaatct atggagcaga ttcggagaat tatgagacct actgatgtcc ctgatacaga    540

tattgaaacc atctgaaaag aaagctaaat accagtatgg tggactgaat tctggacgtc    600

ctgtcactcc acctcgaaca gctaatccgc cgaagaaaag gtgaagaaag gaattctgta    660

aagaaaccat cagatttgtt aaggacatac ttcataatat ataagtgtgc actgtaaaac    720

catccagcca tttgacaccc tttatgatgt cacaccttta acttaaggag acgggtaaag    780

gatcttaaat ttttttctaa tagaaagatg tgctacactg tattgtaata agtatactct    840

gttatagtca acaaagttaa atccaaattc aaaattatcc attaaagtta catcttcatg    900

tatcacaatt tttaaagttg aaaagcatcc cagttaaact agatgtgata gttaaaccag    960

atgaaagcat gatgatccat ctgtgtaatg tggttttagt gttgcttggt tgtttaatta   1020

ttttgagctt gttttgtttt tgtttgtttt cactagaata atggcaaata cttctaattt   1080

ttttccctaa acatttttaa aagtgaaata tgggaagagc tttacagaca ttcaccaact   1140

attattttcc cttgtttatc tacttagata tctgtttaat cttactaaga aaactttcgc   1200

ctcattacat taaaaaggaa ttttagagat tgattgtttt aaaaaaaaat acgcacattg   1260

tccaatccag tgattttaat catacagttt gactgggcaa actttacagc tgatagtgaa   1320

tattttgctt tatacaggaa ttgacactga tttggatttg tgcactctaa tttttaactt   1380

attgatgctc tattgtgcag tagcatttca tttaagataa ggctcatata gtattaccca   1440

actagttggt aatgtgatta tgtggtacct tggctttagg ttttcattcg cacggaacac   1500

cttttggcat gcttaacttc ctggtaacac cttcacctgc attggttttc tttttctttt   1560

ttctttcttt tttttttttt tttttttttt gagttgttgt ttgtttttag atccacagta   1620

catgagaatc cttttttgac aagccttgga aagctgacac tgtctctttt tcctccctct   1680

atacgaagga tgtatttaaa tgaatgctgg tcagtgggac attttgtcaa ctatgggtat   1740

tgggtgctta actgtctaat attgccatgt gaatgttgta tacgattgta aggcttatgt   1800

cactaaagat ttttattctg attttttcat aatcaaaggt catatgatac tgtatagaca   1860

agctttgtag tgaagtatag tagcaataat ttctgtacct gatcaagttt attgcagcct   1920

ttcttttcct atttcttttt tttaagggtt agtattaaca aatggcaatg agtagaaaag   1980

ttaacatgaa gattttagaa ggagagaact tacaggacac agatttgtga ttctttgact   2040

gtgacactat tggatgtgat tctaaaagct tttattgagc attgtcaaat ttgtaagctt   2100

catagggatg gacatcatat ctataatgcc cttctatatg tgctaccata gatgtgacat   2160

ttttgacctt aatatcgtct ttgaaaatgt taaattgaga aacctgttaa cttacatttt   2220

atgaattggc acattgtatt acttactgca agagatattt cattttcagc acagtgcaaa   2280

agttctttaa aatgcatatg tctttttttc taattccgtt ttgttttaaa gcacatttta   2340

aatgtagttt tctcatttag taaaagttgt ctaattgata tgaagcctga ctgatttttt   2400

ttttccttac agtgagacat ttaagcacac attttattca catagatact atgtccttga   2460

catattgaaa tgattctttt ctgaaagtat tcatgatctg catatgatgt attaggttag   2520

gtcacaaagg ttttatctga ggtgatttaa ataacttcct gattggagtg tgtaagctga   2580

gcgatttcta ataaaatttt agttgtacac ttttagtagt catagtgaag caggtctaga   2640

aaataagcct ttggcaggga aaaagggcaa tgttgattaa tctcagtatt aaaccacatt   2700

aatctgtatc ccattgtctg gcttttgtaa attcatccag gtcaagacta agtatgttgg   2760

ttaataggaa tccttttttt tttttttaaa gactaaatgt gaaaaaataa tcactactta   2820

agctaattaa tattggtcat taaatttaaa ggatggaaat ttatcatgtt taaaaattat   2880

tcaagcactc ttaaaaccac ttaaacagcc tccagtcata aaaatgtgtt ctttacaaat   2940

atttgcttgg caacacgact tgaaataaat aaaactttgt ttcttaggag aaaatgattc   3000

tgtaattcca gtgtcactaa tttatattgt tctttcctct gatttttttc aggttagtga   3060

tttttttgta tacaatttaa tccaaatgtt atgacattca gaaatcatga aacacagtag   3120

atatctgtta taatgtggtg tatcacatgg attataaagc aaagttatgg tcgatttcta   3180

ttcttgaaag aatcaactac agtgaatcct ttgcatttga agccttaaca tgcattgctt   3240

taattttgcc cagggacaaa ttttaataat cagcaagact ggtttgtgca aagcgttgag   3300

tcatcaggta tttagagcct agccagctac ccagtatcca tgctgccata tcccttcatt   3360

gtaaaaagta cctaaacatt cgtgaaatga ttttttttag ctgaaaaatg ctggcaagaa   3420

gaattttaaa gcttaaaata ggtggtaaat ttgaagtatg agtgtgttca cgagaaacat   3480

aggcttttca aaaaaatttt tattcaaggc aaagcaagga acatcttgag atatgtctca   3540

agaatataaa gatgtattat tttaagccaa ggagctgaaa tatatctcag tttataaatt   3600

caggtatatt ctttttgtct ccatggcaac cataactttt gaaccaaaaa aaattgtttt   3660

tacatcttta tgctgaaaat gtgtttagat taggaatatg gtcgggctga atttgctgtt   3720

gctccctaac caaatccacc tcttgttttc cttgtgagtc catggctaaa tcaaagctgc   3780

ccctgagaag agacttaatc caagcctgat tgtactagtg gcatcactta gaagtaggct   3840

ttccctcttc ctagtagatc tcaatgtttt ataattcctt aaaacagctg aaaattggga   3900

caacatactt tacgcaatga acagtagtta aataggaaat aaactagttc catataagta   3960

tacacctaga gttttaatta cctttataat gtttcttaaa agtgaaactt agatacaatt   4020

gtgattggat acttagatac taagtgaaac ttagtgtaac aattttgatc tgttaaattg   4080

gattttacat gtacatttga atgccagaat ttctaaataa atcccctggt taggaaattt   4140

taaaagtcaa agcttgtttt cttcaaccac taccttctac attggttgac ttagaccgta   4200

agctttttaa gtttctcatt gtaatttacc ttctcatgca gattgctgat gttttattaa   4260

accttatttt tacaaaaatg aaaaaaaa                                      4288


<210>  496
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  496

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Gln Pro Leu Trp Met Arg Arg Ser Ser Val Val Met Glu Asp Cys 
            20                  25                  30          


His Gln Thr Cys Asn Leu Trp Ser Arg Phe Gly Glu Leu 
        35                  40                  45  


<210>  497
<211>  5298
<212>  DNA
<213>  Homosapiens

<400>  497
atacagagca gcgagcactg aaggcttccc tctttcctta aacctgtcgg gttgtgggct     60

ctctcttttc ccctcttgct cctttctttt ctttttttct gtttttttaa accttccaag    120

gcaagttcat ggatactaag ctgatgtgtt tgttgttctt tttctccctg cctccgctcc    180

tagtgagtaa ccacactggc cgcatcaagg tggtctttac tccgagcatc tgtaaagtga    240

cctgcaccaa gggcagctgt cagaacagct gtgagaaggg gaacaccacc actctcatta    300

gtgagaatgg tcatgctgcc gacaccctga cggccacgaa cttccgagtg gtaatttgcc    360

atcttccatg tatgaatggt ggccagtgca gttcaaggga caaatgtcag tgccctccaa    420

atttcacagg aaaactttgt cagatcccag tccatggtgc cagcgtgcct aaactttatc    480

agcattccca gcagccaggc aaggcgttgg ggacgcatgt catccattca acacatacct    540

tgcctctgac cgtgactagc cagcaaggag tcaaagtgaa atttcctcct aacatagtca    600

atatccatgt gaaacatcct cctgaagctt ccgtccagat acatcaggtt tcaagaattg    660

atggcccaac aggccagaag acaaaagaag ctcaaccagg ccaatcccaa gtctcgtacc    720

aagggcttcc tgtccagaag acccagacca tacattccac atactcccac cagcaggtca    780

ttcctcacgt ctaccccgtg gctgctaaga cacagcttgg ccggtgcttc caggaaacca    840

ttgggtcaca gtgtggcaaa gcgctccctg gcctttcaaa gcaagaggac tgctgtggaa    900

ctgtgggtac ctcctggggc tttaacaaat gccagaaatg ccccaagaaa ccatcttatc    960

atggatacaa ccaaatgatg gaatgcctac cgggttataa gcgggttaac aacacctttt   1020

gccaagatat taatgaatgt cagctacaag gtgtatgccc taatggtgag tgtttgaata   1080

ccatgggcag ctatcgatgt acctgcaaaa taggatttgg gccggatcct accttttcaa   1140

gttgtgttcc tgatccccct gtgatctcgg aagagaaagg gccctgttac cgacttgtca   1200

gttctggaag acagtgtatg caccctctgt ctgttcacct caccaagcag ctctgctgtt   1260

gtagtgtggg caaggcctgg ggcccacact gtgagaaatg tccccttcca ggcacagctg   1320

cttttaagga aatctgtcct ggtggaatgg gttatacggt ttctggcgtt catagacgca   1380

ggccaatcca tcaccatgta ggtaaaggac ctgtatttgt caagccaaag aacactcaac   1440

ctgttgctaa aagtactcat cctccacctc tcccagccaa ggaagagcca gtggaggccc   1500

tgaccttctc ccgggaacac gggccaggag tggcggagcc agaagtggca actgcacccc   1560

ctgaaaagga aataccttca ttggatcaag agaaaaccaa acttgagcct ggtcaacccc   1620

agctgtctcc aggcatttcc actattcatc tgcatccaca gtttccaggt atagtgattg   1680

aaaaaacatc acctcctgtg cctgttgaag tagctcctga agcttctacg tctagtgcca   1740

gccaagtgat tgctcctact caagtgacag aaatcaatga atgtactgtg aaccctgata   1800

tctgtggagc aggacactgc attaacctac cagtgagata tacctgtata tgctacgagg   1860

gctacaggtt cagtgaacaa cagaggaaat gtgtggatat tgatgagtgt actcaggtcc   1920

aacacctctg ctcccagggc cgctgtgaaa acaccgaggg aagtttcttg tgcatttgcc   1980

cagcaggatt tatggccagt gaggagggta ctaactgcat agatgttgac gaatgcctga   2040

ggccggacgt ctgtggggag gggcactgtg tcaatactgt gggggccttc cggtgtgaat   2100

actgtgacag cgggtaccgc atgactcaga gaggccgttg tgaggatatt gatgaatgtt   2160

tgaatccaag cacttgtcca gatgagcagt gtgtgaattc tcctggatct taccagtgcg   2220

ttccctgcac agaaggattc cgaggctgga atggacagtg ccttgatgtg gacgagtgcc   2280

tggaaccaaa cgtctgcgca aatggtgatt gttccaacct tgaaggctcc tacatgtgtt   2340

catgccacaa aggctatacc cggactccgg accacaagca ctgtagagat attgatgaat   2400

gtcagcaagg gaatctatgt gtaaacgggc agtgcaaaaa taccgagggc tccttcaggt   2460

gcacctgtgg acaggggtac cagctgtcgg cagctaaaga ccagtgtgaa gacattgatg   2520

aatgccagca ccgtcatctc tgtgctcatg ggcagtgcag gaacactgag ggctcttttc   2580

aatgtgtgtg tgaccagggt tacagagcat ctgggcttgg agaccactgt gaagatatca   2640

atgaatgctt ggaggacaag agtgtttgcc agagaggaga ctgcattaat actgcagggt   2700

cctatgattg tacttgtccg gatggatttc agctagatga caataaaaca tgtcaagata   2760

ttaatgaatg tgaacatcca gggctctgtg gtccgcaagg ggagtgccta aacacagagg   2820

gttctttcca ttgtgtctgc cagcagggtt tctcaatctc tgcagatggc cgtacgtgtg   2880

aagatattga tgaatgtgta aacaacactg tttgtgacag tcacgggttt tgtgacaata   2940

cagctggctc cttccgctgc ctctgttatc agggctttca agccccacag gatgggcaag   3000

ggtgtgtgga tgtgaatgaa tgtgaactgc tcagtggggt gtgtggtgaa gccttctgtg   3060

aaaacgtgga agggtccttc ctgtgcgtgt gtgctgatga aaaccaagag tacagcccca   3120

tgactgggca gtgccgctcc cggacctcca cagatttaga tgtagatgta gatcaaccca   3180

aagaagaaaa gaaagaatgc tactataatc tcaatgacgc cagtctctgt gataatgtgt   3240

tggcccccaa tgtcacgaaa caagaatgct gctgtacatc aggcgcggga tggggagata   3300

actgcgaaat cttcccctgc ccggtcttgg gaactgctga gttcactgaa atgtgtccca   3360

aagggaaagg ttttgtgcct gctggagaat catcttctga agctggtggt gagaactata   3420

aagatgcaga tgaatgccta ctttttggac aagaaatctg caaaaatggt ttctgtttga   3480

acactcggcc tgggtatgaa tgctactgta agcaagggac gtactatgat cctgtgaaac   3540

tgcagtgctt tgatatggat gaatgtcaag accccagtag ttgtattgat ggccagtgtg   3600

ttaatacaga gggctcttac aactgcttct gtactcaccc catggtcctg gatgcgtcag   3660

aaaaaagatg tatacgaccg gctgagtcaa acgaacaaat agaagaaact gatgtctacc   3720

aagatttgtg ctgggaacat ctgagtgatg aatacgtgtg tagccggcct cttgtgggca   3780

agcagacaac gtacactgag tgctgctgtc tgtatggaga ggcctggggc atgcagtgtg   3840

ccctctgccc cctgaaggat tcagatgact atgctcagct gtgtaacatc cccgtgacgg   3900

gacgccggca gccatatgga cgggacgcct tggttgactt cagtgaacag tatactccag   3960

aagccgatcc ctacttcatc caagaccgtt ttctaaatag ctttgaggag ttacaggctg   4020

aggaatgcgg catcctcaat ggatgtgaaa atggtcgctg tgtgagggtc caggaaggtt   4080

acacctgcga ttgctttgat gggtatcact tggatacggc caagatgacc tgtgtcgatg   4140

taaatgaatg cgatgagttg aacaaccgga tgtctctctg caagaatgcc aagtgcatta   4200

acaccgatgg ttcctacaag tgtttgtgtc tgccaggcta cgtgccttct gacaagccaa   4260

actactgcac tccgttgaat accgccttga atttagagaa agacagtgac ctggagtgaa   4320

acagaatcta cataacctaa gcccatatac tctgcactgt gtaaaggaaa agggagaaat   4380

gtattatact tgagacattg cacctacccc ggaaggctgg aaatacagaa acagcatgga   4440

gttgcaagtc ctctgaagac aatgagagga tttaggatga gcccgatagg tgtggcagac   4500

caaatggaca tttctctaaa aaaccagtat atatagtctg ttcatatgta aaattcaatg   4560

gaagagaggt ggaacagtgc tgttatttta aacagaaggt tgtattatta tgttgttttg   4620

tttttttact attgcttgat taaatttggc atttaaatag tggtggaaat attttatata   4680

attttcattt tttggttgtg cagttccttg gctactgttt ttcttttact tcagtttttt   4740

aaaaatctca aatgaaaaag tcttcgatac aatattgtta agctgtatta taagtattgt   4800

tacacagggt tatgcaattc ccggcctgga gcatttttga aattcaaatt gtctgtcctg   4860

tggagcaggc agtgattttg ttccaaaact ttgtatacac atttggagaa aagtacttta   4920

tattttcagt gttttgtctg attttaatgt ccgttcttag ccaagctgct agcaggtgtt   4980

aattggatcc ctttccttca ctgaaatgga agagtttata agcttacgtt agtattgtaa   5040

tatgtaaagt aagcccaaca aaaattttta aaaatttgat gatccccaat atatctacca   5100

ttgtatgtta aataaatcac catttttgta gaaaaaattc tacctgagag taattgtcaa   5160

tgagtacatg tgtataagtt gtatcccact ctccccactt ttatcttttc cagtggtctt   5220

ctgttaatgt agtgtctttt acaagttaat cattaaattt gttagatctt gttatgggct   5280

aaaaaaaaaa aaaaaaaa                                                 5298


<210>  498
<211>  1396
<212>  PRT
<213>  Homosapiens

<400>  498

Met Asp Thr Lys Leu Met Cys Leu Leu Phe Phe Phe Ser Leu Pro Pro 
1               5                   10                  15      


Leu Leu Val Ser Asn His Thr Gly Arg Ile Lys Val Val Phe Thr Pro 
            20                  25                  30          


Ser Ile Cys Lys Val Thr Cys Thr Lys Gly Ser Cys Gln Asn Ser Cys 
        35                  40                  45              


Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser Glu Asn Gly His Ala Ala 
    50                  55                  60                  


Asp Thr Leu Thr Ala Thr Asn Phe Arg Val Val Ile Cys His Leu Pro 
65                  70                  75                  80  


Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asp Lys Cys Gln Cys Pro 
                85                  90                  95      


Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile Pro Val His Gly Ala Ser 
            100                 105                 110         


Val Pro Lys Leu Tyr Gln His Ser Gln Gln Pro Gly Lys Ala Leu Gly 
        115                 120                 125             


Thr His Val Ile His Ser Thr His Thr Leu Pro Leu Thr Val Thr Ser 
    130                 135                 140                 


Gln Gln Gly Val Lys Val Lys Phe Pro Pro Asn Ile Val Asn Ile His 
145                 150                 155                 160 


Val Lys His Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ser Arg 
                165                 170                 175     


Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys Glu Ala Gln Pro Gly Gln 
            180                 185                 190         


Ser Gln Val Ser Tyr Gln Gly Leu Pro Val Gln Lys Thr Gln Thr Ile 
        195                 200                 205             


His Ser Thr Tyr Ser His Gln Gln Val Ile Pro His Val Tyr Pro Val 
    210                 215                 220                 


Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe Gln Glu Thr Ile Gly Ser 
225                 230                 235                 240 


Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser Lys Gln Glu Asp Cys Cys 
                245                 250                 255     


Gly Thr Val Gly Thr Ser Trp Gly Phe Asn Lys Cys Gln Lys Cys Pro 
            260                 265                 270         


Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln Met Met Glu Cys Leu Pro 
        275                 280                 285             


Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys Gln Asp Ile Asn Glu Cys 
    290                 295                 300                 


Gln Leu Gln Gly Val Cys Pro Asn Gly Glu Cys Leu Asn Thr Met Gly 
305                 310                 315                 320 


Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe Gly Pro Asp Pro Thr Phe 
                325                 330                 335     


Ser Ser Cys Val Pro Asp Pro Pro Val Ile Ser Glu Glu Lys Gly Pro 
            340                 345                 350         


Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln Cys Met His Pro Leu Ser 
        355                 360                 365             


Val His Leu Thr Lys Gln Leu Cys Cys Cys Ser Val Gly Lys Ala Trp 
    370                 375                 380                 


Gly Pro His Cys Glu Lys Cys Pro Leu Pro Gly Thr Ala Ala Phe Lys 
385                 390                 395                 400 


Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr Val Ser Gly Val His Arg 
                405                 410                 415     


Arg Arg Pro Ile His His His Val Gly Lys Gly Pro Val Phe Val Lys 
            420                 425                 430         


Pro Lys Asn Thr Gln Pro Val Ala Lys Ser Thr His Pro Pro Pro Leu 
        435                 440                 445             


Pro Ala Lys Glu Glu Pro Val Glu Ala Leu Thr Phe Ser Arg Glu His 
    450                 455                 460                 


Gly Pro Gly Val Ala Glu Pro Glu Val Ala Thr Ala Pro Pro Glu Lys 
465                 470                 475                 480 


Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr Lys Leu Glu Pro Gly Gln 
                485                 490                 495     


Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile His Leu His Pro Gln Phe 
            500                 505                 510         


Pro Gly Ile Val Ile Glu Lys Thr Ser Pro Pro Val Pro Val Glu Val 
        515                 520                 525             


Ala Pro Glu Ala Ser Thr Ser Ser Ala Ser Gln Val Ile Ala Pro Thr 
    530                 535                 540                 


Gln Val Thr Glu Ile Asn Glu Cys Thr Val Asn Pro Asp Ile Cys Gly 
545                 550                 555                 560 


Ala Gly His Cys Ile Asn Leu Pro Val Arg Tyr Thr Cys Ile Cys Tyr 
                565                 570                 575     


Glu Gly Tyr Arg Phe Ser Glu Gln Gln Arg Lys Cys Val Asp Ile Asp 
            580                 585                 590         


Glu Cys Thr Gln Val Gln His Leu Cys Ser Gln Gly Arg Cys Glu Asn 
        595                 600                 605             


Thr Glu Gly Ser Phe Leu Cys Ile Cys Pro Ala Gly Phe Met Ala Ser 
    610                 615                 620                 


Glu Glu Gly Thr Asn Cys Ile Asp Val Asp Glu Cys Leu Arg Pro Asp 
625                 630                 635                 640 


Val Cys Gly Glu Gly His Cys Val Asn Thr Val Gly Ala Phe Arg Cys 
                645                 650                 655     


Glu Tyr Cys Asp Ser Gly Tyr Arg Met Thr Gln Arg Gly Arg Cys Glu 
            660                 665                 670         


Asp Ile Asp Glu Cys Leu Asn Pro Ser Thr Cys Pro Asp Glu Gln Cys 
        675                 680                 685             


Val Asn Ser Pro Gly Ser Tyr Gln Cys Val Pro Cys Thr Glu Gly Phe 
    690                 695                 700                 


Arg Gly Trp Asn Gly Gln Cys Leu Asp Val Asp Glu Cys Leu Glu Pro 
705                 710                 715                 720 


Asn Val Cys Ala Asn Gly Asp Cys Ser Asn Leu Glu Gly Ser Tyr Met 
                725                 730                 735     


Cys Ser Cys His Lys Gly Tyr Thr Arg Thr Pro Asp His Lys His Cys 
            740                 745                 750         


Arg Asp Ile Asp Glu Cys Gln Gln Gly Asn Leu Cys Val Asn Gly Gln 
        755                 760                 765             


Cys Lys Asn Thr Glu Gly Ser Phe Arg Cys Thr Cys Gly Gln Gly Tyr 
    770                 775                 780                 


Gln Leu Ser Ala Ala Lys Asp Gln Cys Glu Asp Ile Asp Glu Cys Gln 
785                 790                 795                 800 


His Arg His Leu Cys Ala His Gly Gln Cys Arg Asn Thr Glu Gly Ser 
                805                 810                 815     


Phe Gln Cys Val Cys Asp Gln Gly Tyr Arg Ala Ser Gly Leu Gly Asp 
            820                 825                 830         


His Cys Glu Asp Ile Asn Glu Cys Leu Glu Asp Lys Ser Val Cys Gln 
        835                 840                 845             


Arg Gly Asp Cys Ile Asn Thr Ala Gly Ser Tyr Asp Cys Thr Cys Pro 
    850                 855                 860                 


Asp Gly Phe Gln Leu Asp Asp Asn Lys Thr Cys Gln Asp Ile Asn Glu 
865                 870                 875                 880 


Cys Glu His Pro Gly Leu Cys Gly Pro Gln Gly Glu Cys Leu Asn Thr 
                885                 890                 895     


Glu Gly Ser Phe His Cys Val Cys Gln Gln Gly Phe Ser Ile Ser Ala 
            900                 905                 910         


Asp Gly Arg Thr Cys Glu Asp Ile Asp Glu Cys Val Asn Asn Thr Val 
        915                 920                 925             


Cys Asp Ser His Gly Phe Cys Asp Asn Thr Ala Gly Ser Phe Arg Cys 
    930                 935                 940                 


Leu Cys Tyr Gln Gly Phe Gln Ala Pro Gln Asp Gly Gln Gly Cys Val 
945                 950                 955                 960 


Asp Val Asn Glu Cys Glu Leu Leu Ser Gly Val Cys Gly Glu Ala Phe 
                965                 970                 975     


Cys Glu Asn Val Glu Gly Ser Phe Leu Cys Val Cys Ala Asp Glu Asn 
            980                 985                 990         


Gln Glu Tyr Ser Pro Met Thr Gly  Gln Cys Arg Ser Arg  Thr Ser Thr 
        995                 1000                 1005             


Asp Leu  Asp Val Asp Val Asp  Gln Pro Lys Glu Glu  Lys Lys Glu 
    1010                 1015                 1020             


Cys Tyr  Tyr Asn Leu Asn Asp  Ala Ser Leu Cys Asp  Asn Val Leu 
    1025                 1030                 1035             


Ala Pro  Asn Val Thr Lys Gln  Glu Cys Cys Cys Thr  Ser Gly Ala 
    1040                 1045                 1050             


Gly Trp  Gly Asp Asn Cys Glu  Ile Phe Pro Cys Pro  Val Leu Gly 
    1055                 1060                 1065             


Thr Ala  Glu Phe Thr Glu Met  Cys Pro Lys Gly Lys  Gly Phe Val 
    1070                 1075                 1080             


Pro Ala  Gly Glu Ser Ser Ser  Glu Ala Gly Gly Glu  Asn Tyr Lys 
    1085                 1090                 1095             


Asp Ala  Asp Glu Cys Leu Leu  Phe Gly Gln Glu Ile  Cys Lys Asn 
    1100                 1105                 1110             


Gly Phe  Cys Leu Asn Thr Arg  Pro Gly Tyr Glu Cys  Tyr Cys Lys 
    1115                 1120                 1125             


Gln Gly  Thr Tyr Tyr Asp Pro  Val Lys Leu Gln Cys  Phe Asp Met 
    1130                 1135                 1140             


Asp Glu  Cys Gln Asp Pro Ser  Ser Cys Ile Asp Gly  Gln Cys Val 
    1145                 1150                 1155             


Asn Thr  Glu Gly Ser Tyr Asn  Cys Phe Cys Thr His  Pro Met Val 
    1160                 1165                 1170             


Leu Asp  Ala Ser Glu Lys Arg  Cys Ile Arg Pro Ala  Glu Ser Asn 
    1175                 1180                 1185             


Glu Gln  Ile Glu Glu Thr Asp  Val Tyr Gln Asp Leu  Cys Trp Glu 
    1190                 1195                 1200             


His Leu  Ser Asp Glu Tyr Val  Cys Ser Arg Pro Leu  Val Gly Lys 
    1205                 1210                 1215             


Gln Thr  Thr Tyr Thr Glu Cys  Cys Cys Leu Tyr Gly  Glu Ala Trp 
    1220                 1225                 1230             


Gly Met  Gln Cys Ala Leu Cys  Pro Leu Lys Asp Ser  Asp Asp Tyr 
    1235                 1240                 1245             


Ala Gln  Leu Cys Asn Ile Pro  Val Thr Gly Arg Arg  Gln Pro Tyr 
    1250                 1255                 1260             


Gly Arg  Asp Ala Leu Val Asp  Phe Ser Glu Gln Tyr  Thr Pro Glu 
    1265                 1270                 1275             


Ala Asp  Pro Tyr Phe Ile Gln  Asp Arg Phe Leu Asn  Ser Phe Glu 
    1280                 1285                 1290             


Glu Leu  Gln Ala Glu Glu Cys  Gly Ile Leu Asn Gly  Cys Glu Asn 
    1295                 1300                 1305             


Gly Arg  Cys Val Arg Val Gln  Glu Gly Tyr Thr Cys  Asp Cys Phe 
    1310                 1315                 1320             


Asp Gly  Tyr His Leu Asp Thr  Ala Lys Met Thr Cys  Val Asp Val 
    1325                 1330                 1335             


Asn Glu  Cys Asp Glu Leu Asn  Asn Arg Met Ser Leu  Cys Lys Asn 
    1340                 1345                 1350             


Ala Lys  Cys Ile Asn Thr Asp  Gly Ser Tyr Lys Cys  Leu Cys Leu 
    1355                 1360                 1365             


Pro Gly  Tyr Val Pro Ser Asp  Lys Pro Asn Tyr Cys  Thr Pro Leu 
    1370                 1375                 1380             


Asn Thr  Ala Leu Asn Leu Glu  Lys Asp Ser Asp Leu  Glu 
    1385                 1390                 1395     


<210>  499
<211>  6148
<212>  DNA
<213>  Homosapiens

<400>  499
atggcggggg cctggctcag gtgggggctc ctgctctggg cagggctcct cgcgtcctcg     60

gcgcacggcc ggctgcggag gatcacctac gtggtgcacc cgggccccgg cctggcagcc    120

ggcgccttgc ccctgagcgg gcccccgcgt tcgcggacat tcaacgtcgc gctcaacgcc    180

aggtacagcc gcagctcggc ggctgccggc gcccccagcc gtgcctcccc cggggtcccc    240

tcggagagga cccggcgcac gagcaagccg ggcggcgcgg ccctgcaggg gctcagaccg    300

ccgccgccgc cgccgccgga gcctgcgcgt cccgcggtcc ccggcgggca gctccacccc    360

aatcccggcg gccacccggc agccgccccg ttcaccaaac aaggcaggca agttgtgcgc    420

tccaaggtgc cgcaggagac ccagagcggc ggaggctcta ggctgcaggt tcaccagaag    480

cagcagctgc agggggtcaa tgtctgtgga gggcggtgct gtcatggctg gagtaaggcc    540

cctggctccc agaggtgcac caaacctagc tgtgttccgc catgtcagaa tggagggatg    600

tgtctccggc cacaactctg tgtgtgtaaa ccagggacca agggcaaagc ctgtgaaaca    660

atagctgccc aggacacctc gtcaccagtc tttggagggc agagtcctgg ggctgcttcc    720

tcgtggggcc ctcctgagca agcagcaaag catacttcat ctaagaaggc agacactcta    780

ccaagagtca gccctgtggc ccagatgacc ttaaccctca agccgaagcc ttcagtggga    840

ctcccccagc agatacattc tcaagtgact cctctttctt cccagagtgt ggtgattcac    900

catggccaga cccaggaata cgtgctcaag cccaagtact ttccagccca gaaggggatt    960

tcaggagagc agtccactga aggttctttc cctttaagat atgtgcagga tcaagttgcg   1020

gcaccttttc agctgagtaa ccacactggc cgcatcaagg tggtctttac tccgagcatc   1080

tgtaaagtga cctgcaccaa gggcagctgt cagaacagct gtgagaaggg gaacaccacc   1140

actctcatta gtgagaatgg tcatgctgcc gacaccctga cggccacgaa cttccgagtg   1200

gtaatttgcc atcttccatg tatgaatggt ggccagtgca gttcaaggga caaatgtcag   1260

tgccctccaa atttcacagg aaaactttgt cagatcccag tccatggtgc cagcgtgcct   1320

aaactttatc agcattccca gcagccaggc aaggcgttgg ggacgcatgt catccattca   1380

acacatacct tgcctctgac cgtgactagc cagcaaggag tcaaagtgaa atttcctcct   1440

aacatagtca atatccatgt gaaacatcct cctgaagctt ccgtccagat acatcaggtt   1500

tcaagaattg atggcccaac aggccagaag acaaaagaag ctcaaccagg ccaatcccaa   1560

gtctcgtacc aagggcttcc tgtccagaag acccagacca tacattccac atactcccac   1620

cagcaggtca ttcctcacgt ctaccccgtg gctgctaaga cacagcttgg ccggtgcttc   1680

caggaaacca ttgggtcaca gtgtggcaaa gcgctccctg gcctttcaaa gcaagaggac   1740

tgctgtggaa ctgtgggtac ctcctggggc tttaacaaat gccagaaatg ccccaagaaa   1800

ccatcttatc atggatacaa ccaaatgatg gaatgcctac cgggttataa gcgggttaac   1860

aacacctttt gccaagatat taatgaatgt cagctacaag gtgtatgccc taatggtgag   1920

tgtttgaata ccatgggcag ctatcgatgt acctgcaaaa taggatttgg gccggatcct   1980

accttttcaa gttgtgttcc tgatccccct gtgatctcgg aagagaaagg gccctgttac   2040

cgacttgtca gttctggaag acagtgtatg caccctctgt ctgttcacct caccaagcag   2100

ctctgctgtt gtagtgtggg caaggcctgg ggcccacact gtgagaaatg tccccttcca   2160

ggcacagctg cttttaagga aatctgtcct ggtggaatgg gttatacggt ttctggcgtt   2220

catagacgca ggccaatcca tcaccatgta ggtaaaggac ctgtatttgt caagccaaag   2280

aacactcaac ctgttgctaa aagtactcat cctccacctc tcccagccaa ggaagagcca   2340

gtggaggccc tgaccttctc ccgggaacac gggccaggag tggcggagcc agaagtggca   2400

actgcacccc ctgaaaagga aataccttca ttggatcaag agaaaaccaa acttgagcct   2460

ggtcaacccc agctgtctcc aggcatttcc actattcatc tgcatccaca gtttccaggt   2520

atagtgattg aaaaaacatc acctcctgtg cctgttgaag tagctcctga agcttctacg   2580

tctagtgcca gccaagtgat tgctcctact caagtgacag aaatcaatga atgtactgtg   2640

aaccctgata tctgtggagc aggacactgc attaacctac cagtgagata tacctgtata   2700

tgctacgagg gctacaggtt cagtgaacaa cagaggaaat gtgtggatat tgatgagtgt   2760

actcaggtcc aacacctctg ctcccagggc cgctgtgaaa acaccgaggg aagtttcttg   2820

tgcatttgcc cagcaggatt tatggccagt gaggagggta ctaactgcat agatgttgac   2880

gaatgcctga ggccggacgt ctgtggggag gggcactgtg tcaatactgt gggggccttc   2940

cggtgtgaat actgtgacag cgggtaccgc atgactcaga gaggccgttg tgaggatatt   3000

gatgaatgtt tgaatccaag cacttgtcca gatgagcagt gtgtgaattc tcctggatct   3060

taccagtgcg ttccctgcac agaaggattc cgaggctgga atggacagtg ccttgatgtg   3120

gacgagtgcc tggaaccaaa cgtctgcgca aatggtgatt gttccaacct tgaaggctcc   3180

tacatgtgtt catgccacaa aggctatacc cggactccgg accacaagca ctgtagagat   3240

attgatgaat gtcagcaagg gaatctatgt gtaaacgggc agtgcaaaaa taccgagggc   3300

tccttcaggt gcacctgtgg acaggggtac cagctgtcgg cagctaaaga ccagtgtgaa   3360

gacattgatg aatgccagca ccgtcatctc tgtgctcatg ggcagtgcag gaacactgag   3420

ggctcttttc aatgtgtgtg tgaccagggt tacagagcat ctgggcttgg agaccactgt   3480

gaagatatca atgaatgctt ggaggacaag agtgtttgcc agagaggaga ctgcattaat   3540

actgcagggt cctatgattg tacttgtccg gatggatttc agctagatga caataaaaca   3600

tgtcaagata ttaatgaatg tgaacatcca gggctctgtg gtccgcaagg ggagtgccta   3660

aacacagagg gttctttcca ttgtgtctgc cagcagggtt tctcaatctc tgcagatggc   3720

cgtacgtgtg aagatattga tgaatgtgta aacaacactg tttgtgacag tcacgggttt   3780

tgtgacaata cagctggctc cttccgctgc ctctgttatc agggctttca agccccacag   3840

gatgggcaag ggtgtgtgga tgtgaatgaa tgtgaactgc tcagtggggt gtgtggtgaa   3900

gccttctgtg aaaacgtgga agggtccttc ctgtgcgtgt gtgctgatga aaaccaagag   3960

tacagcccca tgactgggca gtgccgctcc cggacctcca cagatttaga tgtagatgta   4020

gatcaaccca aagaagaaaa gaaagaatgc tactataatc tcaatgacgc cagtctctgt   4080

gataatgtgt tggcccccaa tgtcacgaaa caagaatgct gctgtacatc aggcgcggga   4140

tggggagata actgcgaaat cttcccctgc ccggtcttgg gaactgctga gttcactgaa   4200

atgtgtccca aagggaaagg ttttgtgcct gctggagaat catcttctga agctggtggt   4260

gagaactata aagatgcaga tgaatgccta ctttttggac aagaaatctg caaaaatggt   4320

ttctgtttga acactcggcc tgggtatgaa tgctactgta agcaagggac gtactatgat   4380

cctgtgaaac tgcagtgctt tgatatggat gaatgtcaag accccagtag ttgtattgat   4440

ggccagtgtg ttaatacaga gggctcttac aactgcttct gtactcaccc catggtcctg   4500

gatgcgtcag aaaaaagatg tatacgaccg gctgagtcaa acgaacaaat agaagaaact   4560

gatgtctacc aagatttgtg ctgggaacat ctgagtgatg aatacgtgtg tagccggcct   4620

cttgtgggca agcagacaac gtacactgag tgctgctgtc tgtatggaga ggcctggggc   4680

atgcagtgtg ccctctgccc cctgaaggat tcagatgact atgctcagct gtgtaacatc   4740

cccgtgacgg gacgccggca gccatatgga cgggacgcct tggttgactt cagtgaacag   4800

tatactccag aagccgatcc ctacttcatc caagaccgtt ttctaaatag ctttgaggag   4860

ttacaggctg aggaatgcgg catcctcaat ggatgtgaaa atggtcgctg tgtgagggtc   4920

caggaaggtt acacctgcga ttgctttgat gggtatcact tggatacggc caagatgacc   4980

tgtgtcgatg taaatgaatg cgatgagttg aacaaccgga tgtctctctg caagaatgcc   5040

aagtgcatta acaccgatgg ttcctacaag tgtttgtgtc tgccaggcta cgtgccttct   5100

gacaagccaa actactgcac tccgttgaat accgccttga atttagagaa agacagtgac   5160

ctggagtgaa acagaatcta cataacctaa gcccatatac tctgcactgt gtaaaggaaa   5220

agggagaaat gtattatact tgagacattg cacctacccc ggaaggctgg aaatacagaa   5280

acagcatgga gttgcaagtc ctctgaagac aatgagagga tttaggatga gcccgatagg   5340

tgtggcagac caaatggaca tttctctaaa aaaccagtat atatagtctg ttcatatgta   5400

aaattcaatg gaagagaggt ggaacagtgc tgttatttta aacagaaggt tgtattatta   5460

tgttgttttg tttttttact attgcttgat taaatttggc atttaaatag tggtggaaat   5520

attttatata attttcattt tttggttgtg cagttccttg gctactgttt ttcttttact   5580

tcagtttttt aaaaatctca aatgaaaaag tcttcgatac aatattgtta agctgtatta   5640

taagtattgt tacacagggt tatgcaattc ccggcctgga gcatttttga aattcaaatt   5700

gtctgtcctg tggagcaggc agtgattttg ttccaaaact ttgtatacac atttggagaa   5760

aagtacttta tattttcagt gttttgtctg attttaatgt ccgttcttag ccaagctgct   5820

agcaggtgtt aattggatcc ctttccttca ctgaaatgga agagtttata agcttacgtt   5880

agtattgtaa tatgtaaagt aagcccaaca aaaattttta aaaatttgat gatccccaat   5940

atatctacca ttgtatgtta aataaatcac catttttgta gaaaaaattc tacctgagag   6000

taattgtcaa tgagtacatg tgtataagtt gtatcccact ctccccactt ttatcttttc   6060

cagtggtctt ctgttaatgt agtgtctttt acaagttaat cattaaattt gttagatctt   6120

gttatgggct aaaaaaaaaa aaaaaaaa                                      6148


<210>  500
<211>  1722
<212>  PRT
<213>  Homosapiens

<400>  500

Met Ala Gly Ala Trp Leu Arg Trp Gly Leu Leu Leu Trp Ala Gly Leu 
1               5                   10                  15      


Leu Ala Ser Ser Ala His Gly Arg Leu Arg Arg Ile Thr Tyr Val Val 
            20                  25                  30          


His Pro Gly Pro Gly Leu Ala Ala Gly Ala Leu Pro Leu Ser Gly Pro 
        35                  40                  45              


Pro Arg Ser Arg Thr Phe Asn Val Ala Leu Asn Ala Arg Tyr Ser Arg 
    50                  55                  60                  


Ser Ser Ala Ala Ala Gly Ala Pro Ser Arg Ala Ser Pro Gly Val Pro 
65                  70                  75                  80  


Ser Glu Arg Thr Arg Arg Thr Ser Lys Pro Gly Gly Ala Ala Leu Gln 
                85                  90                  95      


Gly Leu Arg Pro Pro Pro Pro Pro Pro Pro Glu Pro Ala Arg Pro Ala 
            100                 105                 110         


Val Pro Gly Gly Gln Leu His Pro Asn Pro Gly Gly His Pro Ala Ala 
        115                 120                 125             


Ala Pro Phe Thr Lys Gln Gly Arg Gln Val Val Arg Ser Lys Val Pro 
    130                 135                 140                 


Gln Glu Thr Gln Ser Gly Gly Gly Ser Arg Leu Gln Val His Gln Lys 
145                 150                 155                 160 


Gln Gln Leu Gln Gly Val Asn Val Cys Gly Gly Arg Cys Cys His Gly 
                165                 170                 175     


Trp Ser Lys Ala Pro Gly Ser Gln Arg Cys Thr Lys Pro Ser Cys Val 
            180                 185                 190         


Pro Pro Cys Gln Asn Gly Gly Met Cys Leu Arg Pro Gln Leu Cys Val 
        195                 200                 205             


Cys Lys Pro Gly Thr Lys Gly Lys Ala Cys Glu Thr Ile Ala Ala Gln 
    210                 215                 220                 


Asp Thr Ser Ser Pro Val Phe Gly Gly Gln Ser Pro Gly Ala Ala Ser 
225                 230                 235                 240 


Ser Trp Gly Pro Pro Glu Gln Ala Ala Lys His Thr Ser Ser Lys Lys 
                245                 250                 255     


Ala Asp Thr Leu Pro Arg Val Ser Pro Val Ala Gln Met Thr Leu Thr 
            260                 265                 270         


Leu Lys Pro Lys Pro Ser Val Gly Leu Pro Gln Gln Ile His Ser Gln 
        275                 280                 285             


Val Thr Pro Leu Ser Ser Gln Ser Val Val Ile His His Gly Gln Thr 
    290                 295                 300                 


Gln Glu Tyr Val Leu Lys Pro Lys Tyr Phe Pro Ala Gln Lys Gly Ile 
305                 310                 315                 320 


Ser Gly Glu Gln Ser Thr Glu Gly Ser Phe Pro Leu Arg Tyr Val Gln 
                325                 330                 335     


Asp Gln Val Ala Ala Pro Phe Gln Leu Ser Asn His Thr Gly Arg Ile 
            340                 345                 350         


Lys Val Val Phe Thr Pro Ser Ile Cys Lys Val Thr Cys Thr Lys Gly 
        355                 360                 365             


Ser Cys Gln Asn Ser Cys Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser 
    370                 375                 380                 


Glu Asn Gly His Ala Ala Asp Thr Leu Thr Ala Thr Asn Phe Arg Val 
385                 390                 395                 400 


Val Ile Cys His Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser Arg 
                405                 410                 415     


Asp Lys Cys Gln Cys Pro Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile 
            420                 425                 430         


Pro Val His Gly Ala Ser Val Pro Lys Leu Tyr Gln His Ser Gln Gln 
        435                 440                 445             


Pro Gly Lys Ala Leu Gly Thr His Val Ile His Ser Thr His Thr Leu 
    450                 455                 460                 


Pro Leu Thr Val Thr Ser Gln Gln Gly Val Lys Val Lys Phe Pro Pro 
465                 470                 475                 480 


Asn Ile Val Asn Ile His Val Lys His Pro Pro Glu Ala Ser Val Gln 
                485                 490                 495     


Ile His Gln Val Ser Arg Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys 
            500                 505                 510         


Glu Ala Gln Pro Gly Gln Ser Gln Val Ser Tyr Gln Gly Leu Pro Val 
        515                 520                 525             


Gln Lys Thr Gln Thr Ile His Ser Thr Tyr Ser His Gln Gln Val Ile 
    530                 535                 540                 


Pro His Val Tyr Pro Val Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe 
545                 550                 555                 560 


Gln Glu Thr Ile Gly Ser Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser 
                565                 570                 575     


Lys Gln Glu Asp Cys Cys Gly Thr Val Gly Thr Ser Trp Gly Phe Asn 
            580                 585                 590         


Lys Cys Gln Lys Cys Pro Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln 
        595                 600                 605             


Met Met Glu Cys Leu Pro Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys 
    610                 615                 620                 


Gln Asp Ile Asn Glu Cys Gln Leu Gln Gly Val Cys Pro Asn Gly Glu 
625                 630                 635                 640 


Cys Leu Asn Thr Met Gly Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe 
                645                 650                 655     


Gly Pro Asp Pro Thr Phe Ser Ser Cys Val Pro Asp Pro Pro Val Ile 
            660                 665                 670         


Ser Glu Glu Lys Gly Pro Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln 
        675                 680                 685             


Cys Met His Pro Leu Ser Val His Leu Thr Lys Gln Leu Cys Cys Cys 
    690                 695                 700                 


Ser Val Gly Lys Ala Trp Gly Pro His Cys Glu Lys Cys Pro Leu Pro 
705                 710                 715                 720 


Gly Thr Ala Ala Phe Lys Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr 
                725                 730                 735     


Val Ser Gly Val His Arg Arg Arg Pro Ile His His His Val Gly Lys 
            740                 745                 750         


Gly Pro Val Phe Val Lys Pro Lys Asn Thr Gln Pro Val Ala Lys Ser 
        755                 760                 765             


Thr His Pro Pro Pro Leu Pro Ala Lys Glu Glu Pro Val Glu Ala Leu 
    770                 775                 780                 


Thr Phe Ser Arg Glu His Gly Pro Gly Val Ala Glu Pro Glu Val Ala 
785                 790                 795                 800 


Thr Ala Pro Pro Glu Lys Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr 
                805                 810                 815     


Lys Leu Glu Pro Gly Gln Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile 
            820                 825                 830         


His Leu His Pro Gln Phe Pro Gly Ile Val Ile Glu Lys Thr Ser Pro 
        835                 840                 845             


Pro Val Pro Val Glu Val Ala Pro Glu Ala Ser Thr Ser Ser Ala Ser 
    850                 855                 860                 


Gln Val Ile Ala Pro Thr Gln Val Thr Glu Ile Asn Glu Cys Thr Val 
865                 870                 875                 880 


Asn Pro Asp Ile Cys Gly Ala Gly His Cys Ile Asn Leu Pro Val Arg 
                885                 890                 895     


Tyr Thr Cys Ile Cys Tyr Glu Gly Tyr Arg Phe Ser Glu Gln Gln Arg 
            900                 905                 910         


Lys Cys Val Asp Ile Asp Glu Cys Thr Gln Val Gln His Leu Cys Ser 
        915                 920                 925             


Gln Gly Arg Cys Glu Asn Thr Glu Gly Ser Phe Leu Cys Ile Cys Pro 
    930                 935                 940                 


Ala Gly Phe Met Ala Ser Glu Glu Gly Thr Asn Cys Ile Asp Val Asp 
945                 950                 955                 960 


Glu Cys Leu Arg Pro Asp Val Cys Gly Glu Gly His Cys Val Asn Thr 
                965                 970                 975     


Val Gly Ala Phe Arg Cys Glu Tyr Cys Asp Ser Gly Tyr Arg Met Thr 
            980                 985                 990         


Gln Arg Gly Arg Cys Glu Asp Ile  Asp Glu Cys Leu Asn  Pro Ser Thr 
        995                 1000                 1005             


Cys Pro  Asp Glu Gln Cys Val  Asn Ser Pro Gly Ser  Tyr Gln Cys 
    1010                 1015                 1020             


Val Pro  Cys Thr Glu Gly Phe  Arg Gly Trp Asn Gly  Gln Cys Leu 
    1025                 1030                 1035             


Asp Val  Asp Glu Cys Leu Glu  Pro Asn Val Cys Ala  Asn Gly Asp 
    1040                 1045                 1050             


Cys Ser  Asn Leu Glu Gly Ser  Tyr Met Cys Ser Cys  His Lys Gly 
    1055                 1060                 1065             


Tyr Thr  Arg Thr Pro Asp His  Lys His Cys Arg Asp  Ile Asp Glu 
    1070                 1075                 1080             


Cys Gln  Gln Gly Asn Leu Cys  Val Asn Gly Gln Cys  Lys Asn Thr 
    1085                 1090                 1095             


Glu Gly  Ser Phe Arg Cys Thr  Cys Gly Gln Gly Tyr  Gln Leu Ser 
    1100                 1105                 1110             


Ala Ala  Lys Asp Gln Cys Glu  Asp Ile Asp Glu Cys  Gln His Arg 
    1115                 1120                 1125             


His Leu  Cys Ala His Gly Gln  Cys Arg Asn Thr Glu  Gly Ser Phe 
    1130                 1135                 1140             


Gln Cys  Val Cys Asp Gln Gly  Tyr Arg Ala Ser Gly  Leu Gly Asp 
    1145                 1150                 1155             


His Cys  Glu Asp Ile Asn Glu  Cys Leu Glu Asp Lys  Ser Val Cys 
    1160                 1165                 1170             


Gln Arg  Gly Asp Cys Ile Asn  Thr Ala Gly Ser Tyr  Asp Cys Thr 
    1175                 1180                 1185             


Cys Pro  Asp Gly Phe Gln Leu  Asp Asp Asn Lys Thr  Cys Gln Asp 
    1190                 1195                 1200             


Ile Asn  Glu Cys Glu His Pro  Gly Leu Cys Gly Pro  Gln Gly Glu 
    1205                 1210                 1215             


Cys Leu  Asn Thr Glu Gly Ser  Phe His Cys Val Cys  Gln Gln Gly 
    1220                 1225                 1230             


Phe Ser  Ile Ser Ala Asp Gly  Arg Thr Cys Glu Asp  Ile Asp Glu 
    1235                 1240                 1245             


Cys Val  Asn Asn Thr Val Cys  Asp Ser His Gly Phe  Cys Asp Asn 
    1250                 1255                 1260             


Thr Ala  Gly Ser Phe Arg Cys  Leu Cys Tyr Gln Gly  Phe Gln Ala 
    1265                 1270                 1275             


Pro Gln  Asp Gly Gln Gly Cys  Val Asp Val Asn Glu  Cys Glu Leu 
    1280                 1285                 1290             


Leu Ser  Gly Val Cys Gly Glu  Ala Phe Cys Glu Asn  Val Glu Gly 
    1295                 1300                 1305             


Ser Phe  Leu Cys Val Cys Ala  Asp Glu Asn Gln Glu  Tyr Ser Pro 
    1310                 1315                 1320             


Met Thr  Gly Gln Cys Arg Ser  Arg Thr Ser Thr Asp  Leu Asp Val 
    1325                 1330                 1335             


Asp Val  Asp Gln Pro Lys Glu  Glu Lys Lys Glu Cys  Tyr Tyr Asn 
    1340                 1345                 1350             


Leu Asn  Asp Ala Ser Leu Cys  Asp Asn Val Leu Ala  Pro Asn Val 
    1355                 1360                 1365             


Thr Lys  Gln Glu Cys Cys Cys  Thr Ser Gly Ala Gly  Trp Gly Asp 
    1370                 1375                 1380             


Asn Cys  Glu Ile Phe Pro Cys  Pro Val Leu Gly Thr  Ala Glu Phe 
    1385                 1390                 1395             


Thr Glu  Met Cys Pro Lys Gly  Lys Gly Phe Val Pro  Ala Gly Glu 
    1400                 1405                 1410             


Ser Ser  Ser Glu Ala Gly Gly  Glu Asn Tyr Lys Asp  Ala Asp Glu 
    1415                 1420                 1425             


Cys Leu  Leu Phe Gly Gln Glu  Ile Cys Lys Asn Gly  Phe Cys Leu 
    1430                 1435                 1440             


Asn Thr  Arg Pro Gly Tyr Glu  Cys Tyr Cys Lys Gln  Gly Thr Tyr 
    1445                 1450                 1455             


Tyr Asp  Pro Val Lys Leu Gln  Cys Phe Asp Met Asp  Glu Cys Gln 
    1460                 1465                 1470             


Asp Pro  Ser Ser Cys Ile Asp  Gly Gln Cys Val Asn  Thr Glu Gly 
    1475                 1480                 1485             


Ser Tyr  Asn Cys Phe Cys Thr  His Pro Met Val Leu  Asp Ala Ser 
    1490                 1495                 1500             


Glu Lys  Arg Cys Ile Arg Pro  Ala Glu Ser Asn Glu  Gln Ile Glu 
    1505                 1510                 1515             


Glu Thr  Asp Val Tyr Gln Asp  Leu Cys Trp Glu His  Leu Ser Asp 
    1520                 1525                 1530             


Glu Tyr  Val Cys Ser Arg Pro  Leu Val Gly Lys Gln  Thr Thr Tyr 
    1535                 1540                 1545             


Thr Glu  Cys Cys Cys Leu Tyr  Gly Glu Ala Trp Gly  Met Gln Cys 
    1550                 1555                 1560             


Ala Leu  Cys Pro Leu Lys Asp  Ser Asp Asp Tyr Ala  Gln Leu Cys 
    1565                 1570                 1575             


Asn Ile  Pro Val Thr Gly Arg  Arg Gln Pro Tyr Gly  Arg Asp Ala 
    1580                 1585                 1590             


Leu Val  Asp Phe Ser Glu Gln  Tyr Thr Pro Glu Ala  Asp Pro Tyr 
    1595                 1600                 1605             


Phe Ile  Gln Asp Arg Phe Leu  Asn Ser Phe Glu Glu  Leu Gln Ala 
    1610                 1615                 1620             


Glu Glu  Cys Gly Ile Leu Asn  Gly Cys Glu Asn Gly  Arg Cys Val 
    1625                 1630                 1635             


Arg Val  Gln Glu Gly Tyr Thr  Cys Asp Cys Phe Asp  Gly Tyr His 
    1640                 1645                 1650             


Leu Asp  Thr Ala Lys Met Thr  Cys Val Asp Val Asn  Glu Cys Asp 
    1655                 1660                 1665             


Glu Leu  Asn Asn Arg Met Ser  Leu Cys Lys Asn Ala  Lys Cys Ile 
    1670                 1675                 1680             


Asn Thr  Asp Gly Ser Tyr Lys  Cys Leu Cys Leu Pro  Gly Tyr Val 
    1685                 1690                 1695             


Pro Ser  Asp Lys Pro Asn Tyr  Cys Thr Pro Leu Asn  Thr Ala Leu 
    1700                 1705                 1710             


Asn Leu  Glu Lys Asp Ser Asp  Leu Glu 
    1715                 1720         


<210>  501
<211>  659
<212>  DNA
<213>  Homosapiens

<400>  501
tatcagcaag tctccttttg cgggtggcgg cgaacgcgga gagcacgcca tgaaggcctc     60

gggcacacta cgagagtaca aagtagtggg tcgctgcctg cccaccccca aatgccacac    120

accacccctc taccgcatgc gaatctttgc gcctaatcat gtcgtcgcca agtcccgctt    180

ctggtacttc gtatctcagt taaagaagat gaagaagtct tcaggggaga ttgtctactg    240

tgggcaggtg tttgagaagt tccccttgcg ggtgaagaac ttcgggatct ggctgcgcta    300

tgactcccgg agcggcaccc acaacatgta ccgggaatac cgggacctga ccaccgcagg    360

cgctgtcacc cggtgctacc gagacatgag cgcccggcac ggcggccggg cccactccat    420

tcagatcatg aaggtggagg agatcgcggc cagcaagtgc cgccggccgg ctgtcaagca    480

gttccacgac tccaagatca agttcccgct gccccaccgg gtcctgcgcc gtcagcacaa    540

gccacgcttc accaccaaga ggcccaacac cttcttctag gtgcagggcc ctcgcccggg    600

tgtgccccaa ataaactcag gaacgcccca gaaaaaaaaa tttatcagca agaaaataa     659


<210>  502
<211>  176
<212>  PRT
<213>  Homosapiens

<400>  502

Met Lys Ala Ser Gly Thr Leu Arg Glu Tyr Lys Val Val Gly Arg Cys 
1               5                   10                  15      


Leu Pro Thr Pro Lys Cys His Thr Pro Pro Leu Tyr Arg Met Arg Ile 
            20                  25                  30          


Phe Ala Pro Asn His Val Val Ala Lys Ser Arg Phe Trp Tyr Phe Val 
        35                  40                  45              


Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys 
    50                  55                  60                  


Gly Gln Val Phe Glu Lys Phe Pro Leu Arg Val Lys Asn Phe Gly Ile 
65                  70                  75                  80  


Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr His Asn Met Tyr Arg Glu 
                85                  90                  95      


Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Arg Cys Tyr Arg Asp 
            100                 105                 110         


Met Ser Ala Arg His Gly Gly Arg Ala His Ser Ile Gln Ile Met Lys 
        115                 120                 125             


Val Glu Glu Ile Ala Ala Ser Lys Cys Arg Arg Pro Ala Val Lys Gln 
    130                 135                 140                 


Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His Arg Val Leu Arg 
145                 150                 155                 160 


Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro Asn Thr Phe Phe 
                165                 170                 175     


<210>  503
<211>  557
<212>  DNA
<213>  Homosapiens

<400>  503
tttgcgggtg gcggcgaacg cggagagcac gccatgaagg cctcgggcac actacgagag     60

tacaaagtag tgggtcgctg cctgcccacc cccaaatgcc acacaccacc cctctaccgc    120

atgcgaatct ttgcgcctaa tcatgtcgtc gccaagtccc gcttctggta cttcgtatct    180

cagttaaaga agatgaagaa aacttcggga tctggctgcg ctatgactcc cggagcggca    240

cccacaacat gtaccgggaa taccgggacc tgaccaccgc aggcgctgtc acccggtgct    300

accgagacat gagcgcccgg cacggcggcc gggcccactc cattcagatc atgaaggtgg    360

aggagatcgc ggccagcaag tgccgccggc cggctgtcaa gcagttccac gactccaaga    420

tcaagttccc gctgccccac cgggtcctgc gccgtcagca caagccacgc ttcaccacca    480

agaggcccaa caccttcttc taggtgcagg gccctcgccc gggtgtgccc caaataaact    540

caggaacgcc ccagaaa                                                   557


<210>  504
<211>  84
<212>  PRT
<213>  Homosapiens

<400>  504

Met Tyr Arg Glu Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Arg 
1               5                   10                  15      


Cys Tyr Arg Asp Met Ser Ala Arg His Gly Gly Arg Ala His Ser Ile 
            20                  25                  30          


Gln Ile Met Lys Val Glu Glu Ile Ala Ala Ser Lys Cys Arg Arg Pro 
        35                  40                  45              


Ala Val Lys Gln Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His 
    50                  55                  60                  


Arg Val Leu Arg Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro 
65                  70                  75                  80  


Asn Thr Phe Phe 
                


<210>  505
<211>  588
<212>  DNA
<213>  Homosapiens

<400>  505
tttgcgggtg gcggcgaacg cggagagcac gccatgaagg cctcgggcac actacgagag     60

tacaaagtag tgggtcgctg cctgcccacc cccaaatgcc acacaccacc cctctaccgc    120

atgcgaatct ttgcgcctaa tcatgtcgtc gccaagtccc gcttctggta cttcgtatct    180

cagttaaaga agatgaagaa gtcttcaggg gagattgtct actgtgggca gaacttcggg    240

atctggctgc gctatgactc ccggagcggc acccacaaca tgtaccggga ataccgggac    300

ctgaccaccg caggcgctgt cacccggtgc taccgagaca tgagcgcccg gcacggcggc    360

cgggcccact ccattcagat catgaaggtg gaggagatcg cggccagcaa gtgccgccgg    420

ccggctgtca agcagttcca cgactccaag atcaagttcc cgctgcccca ccgggtcctg    480

cgccgtcagc acaagccacg cttcaccacc aagaggccca acaccttctt ctaggtgcag    540

ggccctcgcc cgggtgtgcc ccaaataaac tcaggaacgc cccagaaa                 588


<210>  506
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  506

Met Lys Ala Ser Gly Thr Leu Arg Glu Tyr Lys Val Val Gly Arg Cys 
1               5                   10                  15      


Leu Pro Thr Pro Lys Cys His Thr Pro Pro Leu Tyr Arg Met Arg Ile 
            20                  25                  30          


Phe Ala Pro Asn His Val Val Ala Lys Ser Arg Phe Trp Tyr Phe Val 
        35                  40                  45              


Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys 
    50                  55                  60                  


Gly Gln Asn Phe Gly Ile Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr 
65                  70                  75                  80  


His Asn Met Tyr Arg Glu Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val 
                85                  90                  95      


Thr Arg Cys Tyr Arg Asp Met Ser Ala Arg His Gly Gly Arg Ala His 
            100                 105                 110         


Ser Ile Gln Ile Met Lys Val Glu Glu Ile Ala Ala Ser Lys Cys Arg 
        115                 120                 125             


Arg Pro Ala Val Lys Gln Phe His Asp Ser Lys Ile Lys Phe Pro Leu 
    130                 135                 140                 


Pro His Arg Val Leu Arg Arg Gln His Lys Pro Arg Phe Thr Thr Lys 
145                 150                 155                 160 


Arg Pro Asn Thr Phe Phe 
                165     


<210>  507
<211>  1998
<212>  DNA
<213>  Homosapiens

<400>  507
cctgacctcg tgatccgccc gcctgtgcct cccaaagtgt tgggattaca ggcgtgagcc     60

actgtgccca gcctccagca tgattttttt aggccgttct tttgtttgaa agaattcaac    120

taaggatcca ctctgcctgc ctgaccggtt tcttcctttc ttctctctca tcgggtcccg    180

agttcccatg actgcagctt ccagaagagc agagctttgg tatcctactc acagcgccaa    240

aactgcaggg gccaagatgc aaatcttccg cacaaaagac agctttgcag ggctgcttct    300

gtttgcaggc cctctgaaca gccatctcaa aacatgtcaa agaagtatat cttggggaaa    360

gatacaaaat tcttgtgtgc agcctctttt ggactccagc tcttgttctc tcgctgaatc    420

ccaccgccac cccttcaagt catcggctgt gattcacctg tgggtttctg aaggctagaa    480

gcttccacaa tgagccagga aacaagttct gattggctgg gaacagacct ctgctccaag    540

attcagggct ggcagtattc cttctgttct ggtggctcga tcttcattgc tttcctctgg    600

acttgtaagt tattccaaca aaccccagct gctctgcagt gaaatgttcc aaataattaa    660

tatttctgca ggaattacct tgtaaaagat atgtgctttt aagtatttgg ttattgtgca    720

aatgtttttg actacctttt gtggccaatt ttctccttca gcgggctcat gtataatttt    780

agataaaagt acaaggaaat tatgattcca taatcataag tctactttca gcaatacacg    840

tatcttcaga gaatctcagc ctccctgcag catcctcctg gtgcacagaa aaactgctga    900

attctggcaa gatactcaaa ggattctgac gggtgaccat ctcaggccgg agatatgccc    960

aaccaactgg aaaagcagag acagccatgg acagatctgc tgacgctaaa gtttatagac   1020

agctgaggtg caacccatat aatcacccag atgttattag gccatgatca ttctgtagta   1080

agctacctcc cttctgtgtt tcctctcacc tgacagccta ttgtgggcac tttcaaggcc   1140

ccactgtgtc caaatcacac caccaccaaa gctcacagaa gcacgctggt agatttctcc   1200

tctttggtgg tttcccatga ccagccaagg gaaataccca acaatcattc tcagtgtgca   1260

cagatttacc ttcagctttt ttggttatat tgtcattatt attttctttg tccagtggga   1320

gagttaaggg gcctgctatg gactgaactc tgtccccctc aaattcatat gttgaagccc   1380

caaccttcaa catgactata tttgaaaaca gtccctttat ggaggtaaag ttaaatgaga   1440

tcataagagt ggggcccttg ttcgatagaa ctggtgtcct tacaagaaga ggaagaggct   1500

gagtgcagtg gctcaagcct ataatcccag cactttggga agctgaggca ggaggtacgc   1560

ttgggcccag gagttcaaga ccagcttggg caacataaca agaccctatc tctacagaaa   1620

aaaattaaaa attaaccagg tgtgatggca tgtgcttgtg gtaccagcta ctcaggaggc   1680

tgagatgggt ggatggcttg agcctgggag gtcaaggttg cagtgagctg tgatagcact   1740

gcactccagc ctgggtaaca gagcaagacc ctgtccctcc ccacaccacc ccaactcccc   1800

ccaaaaagga agagatacca gagtgcactc tctcgatctc tctctctctc ttccacgtga   1860

ggacacagaa gaaaaaaaaa aaagcccatc tgcaaggcag gaagacggcc ttcaacagca   1920

acgaaatcag tcagcacctt ggtttggact gcttggtctc cagaacgagg gaaaataaat   1980

taaaataaat gtctgtag                                                 1998


<210>  508
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  508

Met Thr Ala Ala Ser Arg Arg Ala Glu Leu Trp Tyr Pro Thr His Ser 
1               5                   10                  15      


Ala Lys Thr Ala Gly Ala Lys Met Gln Ile Phe Arg Thr Lys Asp Ser 
            20                  25                  30          


Phe Ala Gly Leu Leu Leu Phe Ala Gly Pro Leu Asn Ser His Leu Lys 
        35                  40                  45              


Thr Cys Gln Arg Ser Ile Ser Trp Gly Lys Ile Gln Asn Ser Cys Val 
    50                  55                  60                  


Gln Pro Leu Leu Asp Ser Ser Ser Cys Ser Leu Ala Glu Ser His Arg 
65                  70                  75                  80  


His Pro Phe Lys Ser Ser Ala Val Ile His Leu Trp Val Ser Glu Gly 
                85                  90                  95      


<210>  509
<211>  3817
<212>  DNA
<213>  Homosapiens

<400>  509
cagggactta ccaatttggg attcttccag gagctgaaaa ctgattgcaa atatgaaaca     60

gatttcacta caggacttga accctacatt aaaaaacaac aagctcccca aaataattga    120

aaaagatctt caccaaagag tagctgcaat gtgaatggca ggatatgaag caagtaagag    180

atggtgaaaa gattatctta agcttggaat taagtgatga aagggacctt cgaaattatc    240

aactctaaat acttctttac aggaaaattg aaagcagtta agaacctgcc ccctaccgtg    300

gagttcttgg tgccgtgagt tggagttctt ggtgcctggg tgcgtcccca aggccactgg    360

tcttcagatc tttcttactt gagaagaacg cctccgcctc ctggctctcc caccagtggt    420

attgccacca ccacacacca gcataaagca cagattgctg cccagctcct tggagagggg    480

ccagtgcatt tgtcaggaat tgaaaagttt tggagccagt tcgaggactt tctcctgcac    540

aaagtgttgg ctggaagcat gattatctca cacagagcgt tggaattact tcatgatgat    600

ttcaaagaaa attttcttct ctaaacactc ttatcccaag ggcatcctaa agttcctctg    660

gaatgcattg ggtgggagag aaagttctat gtcaactctt ctggcagagg gaaaagctga    720

ccgaggaagt caaaatgaaa gaaagaagca gacaggactg aggctccctg agatgcagaa    780

actgaggcac agagcaagga tgtgccacag cagaagcaag ttgtgttggc agtaggaaac    840

aagataaaga gaagaactca aagaattgag agaaggcttt gaacatgatg atggagaaat    900

aacactcttg ggagaaatga agatactttc tcctccctgg tttacctgag tttccagcac    960

ccagtgataa gaaaggatgg cattagtgat gtgtacacct gcagtgatag cttcaccttt   1020

ctaaagcaga tgccgtggta gacattttgc cagccctcct ttcactatac acacagcttg   1080

gtgtacgctg gcagactttt gacctaattt cttaaccctc aaatattcca agacagaaca   1140

aagcacacaa caaaaccaga atgaggccgg gcaaagtggc tcatgcccgt aatcccagca   1200

ctttgggagg ctaaggggtg ggcagatcac ttgaggtcag gagtttgaga ccagcctagg   1260

caacatggtg aaacccagtc tctactgaaa atacaaaaat cagccgggtg tggtggcaaa   1320

tgcctgtaat cccagctact ggggaggctg agacacaaga atcacttgaa cccaggaggg   1380

ggagtttgca gtgagccgag attgtgccac tgcatgccag tctgaacaac agagcaagac   1440

tctgtcacaa aaacaaacaa aaaactgaat gaatggaagc agataagtgc agagagaaac   1500

actgatttac cttcagaaag ataaaaaagt agtatattga tatacttgta tattgctatc   1560

tactagtata gcttcagttg gtgtatgagt atagaactat tgggttgttc tttatgtgat   1620

tactccttcc cagttttagt aaagtattcc aatttgaggg aaattctttc atttgtcaat   1680

aaaataaaaa gaggtaagtt ttaaaatctg tatagttctt ccttcatgct agttgcctct   1740

ctttttgata tttcttctat aaaaatcttt tcttacattc agttttcatt gtatagatca   1800

tgaaggaacc atagtgatta tcaaagatca gccgataagt tcaaggcaga gttccacctt   1860

tccccatgaa gcccttccag acttgtttac atgtaacacc cttgaaggca agactcatgt   1920

ctatgctatc tttgctgcta tttggcacgt attaggtgta agggcaatta gaccatatca   1980

attaatgatc agtaagaatg gataaagtag atgtttttgt gagcctctca aagaagatgt   2040

atagaatatt ttggaaatgg gcccaatttg tttctaaagg aaaatttact ttcaaattaa   2100

aaaaaaaaaa tcactcaaat gagattttgg gggatttcat atgattaact ctttacatta   2160

tcttgtggta attatacaga aatctgtatt tatgtaaaca cagtaaatgc atcataacac   2220

tagaataagt atacaaatac tgcatgtcaa attaggttat aatcactttc aagggacgtg   2280

atttcctagc taaacagatt cgtttacatt ttgcaaaata aaaaataagt gaaaataact   2340

atataaaatc aggcttacag ctggacagat cttcttggca atggtccaga cactgagtag   2400

ggaaaagccc ctccagctga ggaacgttca ggacgctcag gacgactttg caggcgcggc   2460

cgggagagag gccatttttg gggttgcctt gactgtgcac cctgttcctg gctacctatg   2520

gggagataag ctgcattcac atatcagatg agactctttt tgtgagaggt ctggggtggg   2580

atgtgggaag tggagtgaaa acctgcttag taggggagga aaaaaacaag caatccaaca   2640

cttcaccttt aggtaataaa cataatagaa aaagtcagga attctctaac taaaaagcag   2700

acagtggaag ctagcatcgg actcactgaa ttttagaatc agggtctgtg taccatggat   2760

tatctggccc tgcccttgtc actggatgag aagattctgg ctatagggca agaagcagtg   2820

cttggaccga gatccagaat gttaccctca aatctgaagc ttatttatga gataaataaa   2880

gctcatattt tcaagagaga taattatttt aaaacttctc atttcaatgt gtaccttaaa   2940

aaaataaata cattttgggc caggtgcgat ggttcatgcc tgtaatccca gcactttggg   3000

aggccgaggt gggcagatca tgaggtcagt ttgagaccag cctggccaac atagtgaaac   3060

tccgtctcta ctaaaaataa aaataaaaaa attagctggg catagtggca cgtacctgta   3120

gtcccagcta cttaggaggc tgaagcagga gaatcgcttg aacccatgag gcagaggttg   3180

tggtgagccc aaattgcgcc actgcactcc agcctgggca acagagcaag actccatctc   3240

aaaaaaccaa tcaaccaacc aaccaacaaa aaacatttca catctccctg acgtagccaa   3300

cattttctcc aacattctct tattttgatg gcagaagggc ataactgtaa atctcagttt   3360

ttatatggta ttgtataata tagtggcatc ctttgcggcc agttgattgt gaagagcagt   3420

ttgcctttac ttagcttcca tgaacattag ctttaaatgc tcattgacat taatgagagc   3480

cagtttgcta aatctgtgtc tccttcatgt tcatttgcta cttagttttg ttgattccaa   3540

gaagtcacta atttttttaa atcatagatt ctgatttcga ggtagcttca tttttctagt   3600

gttgagtaaa atgtgtgtgt gtgtgtgctt tagtttaatt aatactaatt tttattcaaa   3660

atatatttgt tgagcactta ctctctgctg tggctgggca tacattactt tctttccaca   3720

gtccgttggt tgaattgtcc tgagcagggg ttgacaaatg atggcctgtg agccaaatct   3780

accccactgc ctgtttttgt aaataaagct ttatcag                            3817


<210>  510
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  510

Met Ile Ser Lys Lys Ile Phe Phe Ser Lys His Ser Tyr Pro Lys Gly 
1               5                   10                  15      


Ile Leu Lys Phe Leu Trp Asn Ala Leu Gly Gly Arg Glu Ser Ser Met 
            20                  25                  30          


Ser Thr Leu Leu Ala Glu Gly Lys Ala Asp Arg Gly Ser Gln Asn Glu 
        35                  40                  45              


Arg Lys Lys Gln Thr Gly Leu Arg Leu Pro Glu Met Gln Lys Leu Arg 
    50                  55                  60                  


His Arg Ala Arg Met Cys His Ser Arg Ser Lys Leu Cys Trp Gln 
65                  70                  75                  


<210>  511
<211>  2170
<212>  DNA
<213>  Homosapiens

<400>  511
tctctgaaat gagatgagtg gaaaatgcct taaacaggtg gatgtggaac aggtcgggga     60

ctttaaggac ttcagtggag gaggggtggg ttggggaagg gaaacaaatg aagatgtctt    120

agaagtcact gcaatttata tggaatctgt tcaacgccga cactgaacca tatgagaaga    180

cgtttgaaac tattgctttg ctgaaaacat ctgactgcca ggctaggatg tgacacttaa    240

gggacttacc aatttgggat tcttccagga gctgaaaact gattgcaaat atgaaacaga    300

tttcactaca ggacttgaac cctacattaa aaaacaacaa gctccccaaa ataattgaaa    360

aagatcttca ccaaagagta gctgcaatgt gaatggcagg atatgaagca agtaagagag    420

ctatcactgc caaaggctac tgactaatgg tgaaaagatt atcttaagct tggaattaag    480

tgatgaaagg gaccttcgaa attatcaact ctaaatactt ctttacagga aaattgaaag    540

cagttaagaa cctgccccct accgtggagt tcttggtgcc gtgagttgga gttcttggtg    600

cctgggtgcg tccccaaggc cactggtctt cagatctttc ttacttgaga agaacgcctc    660

cgcctcctgg ctctcccacc agtggtattg ccaccaccac acaccagcat aaagcacaga    720

ttgctgccca gctccttgga gaggggccag tgcatttgtc aggaattgaa aagttttgga    780

gccagttcga ggactttctc ctgcacaaag tgttggctgg aagcatgatt atctcacaca    840

gagcgttgga attacttcat gatgatttca aagaaaattt tcttctctaa acactcttat    900

cccaagggca tcctaaagtt cctctggaat gcattgggtg ggagagaaag ttctatgtca    960

actcttctgg cagagggaaa agctgaccga ggaagtcaaa atgaaagaaa gaagcagaca   1020

ggactgaggc tccctgagat gcagaaactg aggcacagag caaggggcta ggattcttga   1080

ctttcttctg cagaacactg aaacatgcct cctctttcct ggccccacca agcagagttt   1140

aggcttcaag aagactgaat gcatctgtac agagcacaat cccttctcca agaaggaaac   1200

catggggctt atcaagaaag gcgtacactg aagagactgg aaagtgaaga tgcactattt   1260

gtcaagatgt gccacagcag aagcaagttg tgttggcagt aggaaacaag ataaagagaa   1320

gaactcaaag aattgagaga aggctttgaa catgatgatg gagaaataac actcttggga   1380

gaaatgaaga tactttctcc tccctggttt acctgagttt ccagcaccca gtgataagaa   1440

aggatggcat tagtgatgtg tacacctgca gtgatagctt cacctttcta aagcagatgc   1500

cgtggtagac attttgccag ccctcctttc actatacaca cagcttggtg tacgctggca   1560

gacttttgac ctaatttctt aaccctcaaa tattccaaga cagaacaaag cacacaacaa   1620

aaccagaatg aggccgggca aagtggctca tgcccgtaat cccagcactt tgggaggcta   1680

aggggtgggc agatcacttg aggtcaggag tttgagacca gcctaggcaa catggtgaaa   1740

cccagtctct actgaaaata caaaaatcag ccgggtgtgg tggcaaatgc ctgtaatccc   1800

agctactggg gaggctgaga cacaagaatc acttgaaccc aggaggggga gtttgcagtg   1860

agccgagatt gtgccactgc atgccagtct gaacaacaga gcaagactct gtcacaaaaa   1920

caaacaaaaa actgaatgaa tggaagcaga taagtgcaga gagaaacact gatttacctt   1980

cagaaagata aaaaagtagt atattgatat acttgtatat tgctatctac tagtatagct   2040

tcagttggtg tatgagtata gaactattgg gttgttcttt atgtgattac tccttcccag   2100

ttttagtaaa gtattccaat ttgagggaaa ttctttcatt tgtcaataaa ataaaaagag   2160

gtaagtttta                                                          2170


<210>  512
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  512

Met Ile Ser Lys Lys Ile Phe Phe Ser Lys His Ser Tyr Pro Lys Gly 
1               5                   10                  15      


Ile Leu Lys Phe Leu Trp Asn Ala Leu Gly Gly Arg Glu Ser Ser Met 
            20                  25                  30          


Ser Thr Leu Leu Ala Glu Gly Lys Ala Asp Arg Gly Ser Gln Asn Glu 
        35                  40                  45              


Arg Lys Lys Gln Thr Gly Leu Arg Leu Pro Glu Met Gln Lys Leu Arg 
    50                  55                  60                  


His Arg Ala Arg Gly 
65                  


<210>  513
<211>  3958
<212>  DNA
<213>  Homosapiens

<400>  513
tttttttttt ttttttgctt aaaaaaaagc catgacggct ctcccacaat tcatcttccc     60

tgcgccatct ttgtattatt tctaatttat tttggatgtc aaaaggcact gatgaagata    120

ttttctctgg agtctccttc tttctaaccc ggctctcccg atgtgaaccg agccgtcgtc    180

cgcccgccgc cgccgccgcc gccgccgccg cccgccccgc agcccaccat gtctcgccgc    240

aagcaaggca aaccccagca cttaagcaaa cgggaattct cgcccgagcc tcttgaagcc    300

attcttacag atgatgaacc agaccacggc ccgttgggag ctccagaagg ggatcatgac    360

ctcctcacct gtgggcagtg ccagatgaac ttcccattgg gggacattct tatttttatc    420

gagcacaaac ggaaacaatg caatggcagc ctctgcttag aaaaagctgt ggataagcca    480

ccttcccctt caccaatcga gatgaaaaaa gcatccaatc ccgtggaggt tggcatccag    540

gtcacgccag aggatgacga ttgtttatca acgtcatcta gaggaatttg ccccaaacag    600

gaacacatag cagataaact tctgcactgg aggggcctct cctcccctcg ttctgcacat    660

ggagctctaa tccccacgcc tgggatgagt gcagaatatg ccccgcaggg tatttgtaaa    720

gatgagccca gcagctacac atgtacaact tgcaaacagc cattcaccag tgcatggttt    780

ctcttgcaac acgcacagaa cactcatgga ttaagaatct acttagaaag cgaacacgga    840

agtcccctga ccccgcgggt tggtatccct tcaggactag gtgcagaatg tccttcccag    900

ccacctctcc atgggattca tattgcagac aataacccct ttaacctgct aagaatacca    960

ggatcagtat cgagagaggc ttccggcctg gcagaagggc gctttccacc cactcccccc   1020

ctgtttagtc caccaccgag acatcacttg gacccccacc gcatagagcg cctgggggcg   1080

gaagagatgg ccctggccac ccatcacccg agtgcctttg acagggtgct gcggttgaat   1140

ccaatggcta tggagcctcc cgccatggat ttctctagga gacttagaga gctggcaggg   1200

aacacgtcta gcccaccgct gtccccaggc cggcccagcc ctatgcaaag gttactgcaa   1260

ccattccagc caggtagcaa gccgcccttc ctggcgacgc cccccctccc tcctctgcaa   1320

tccgcccctc ctccctccca gcccccggtc aagtccaagt catgcgagtt ctgcggcaag   1380

acgttcaaat ttcagagcaa cctggtggtg caccggcgca gccacacggg cgagaagccc   1440

tacaagtgca acctgtgcga ccacgcgtgc acccaggcca gcaagctgaa gcgccacatg   1500

aagacgcaca tgcacaaatc gtcccccatg acggtcaagt ccgacgacgg tctctccacc   1560

gccagctccc cggaacccgg caccagcgac ttggtgggca gcgccagcag cgcgctcaag   1620

tccgtggtgg ccaagttcaa gagcgagaac gaccccaacc tgatcccgga gaacggggac   1680

gaggaggaag aggaggacga cgaggaagag gaagaagagg aggaagagga ggaggaggag   1740

ctgacggaga gcgagagggt ggactacggc ttcgggctga gcctggaggc ggcgcgccac   1800

cacgagaaca gctcgcgggg cgcggtcgtg ggcgtgggcg acgagagccg cgccctgccc   1860

gacgtcatgc agggcatggt gctcagctcc atgcagcact tcagcgaggc cttccaccag   1920

gtcctgggcg agaagcataa gcgcggccac ctggccgagg ccgagggcca cagggacact   1980

tgcgacgaag actcggtggc cggcgagtcg gaccgcatag acgatggcac tgttaatggc   2040

cgcggctgct ccccgggcga gtcggcctcg gggggcctgt ccaaaaagct gctgctgggc   2100

agccccagct cgctgagccc cttctctaag cgcatcaagc tcgagaagga gttcgacctg   2160

cccccggccg cgatgcccaa cacggagaac gtgtactcgc agtggctcgc cggctacgcg   2220

gcctccaggc agctcaaaga tcccttcctt agcttcggag actccagaca atcgcctttt   2280

gcctcctcgt cggagcactc ctcggagaac gggagcttgc gcttctccac accgcccggg   2340

gagctggacg gagggatctc ggggcgcagc ggcacgggaa gtggagggag cacgccccat   2400

attagtggtc cgggcccggg caggcccagc tcaaaagagg gcagacgcag cgacacttgt   2460

tcttcacaca cccccattcg gcgtagtacc cagagagctc aagatgtgtg gcagttttcg   2520

gatggaagct cgagagccct taagttctga gaaaatttga agcccccagg ggtggggtgg   2580

acgcgtgccg cccagtcgac gtcagcgtgg tctgtcatcc tgctagtttg tgatgttttc   2640

tgacagtagc ctccaagaag ccgttgtgcg aagacagagt cctgcagagt ccttccagcc   2700

taggcctgca gcgccatttt atttatattt tttaataaaa agtaaaaaca aaaaaacaga   2760

cccacattgg aacagtgaat cagtcccata gagagggccc gtggaccatc gctgtcatga   2820

gtgatgccct ggcccttctg aaaccagcca acctaattac ctgtattgtg gaaatgcgca   2880

tgagtcccca accccttgtt tctatacatt ctatgttgtc ttttaaaaag tgtgcttaac   2940

attgacacaa taaatgttgg agctttaggt ggtgtttgct tgttctttaa tttttaatgc   3000

ttataagaca atgaggctgc ttatgatttt gtacttctgt acctgtttcc tacagacacc   3060

catcgggtgg gtaggaggaa cagatttgag aaatgggcag gagatgtagg aggggaacta   3120

ggttaccgct tatcagatgg cataaatttt caaggagaat caaaatgcaa aacttgggaa   3180

taaatcatag caatatcata attaatgtag tagtaatatt gctgtttatt aatgctgaag   3240

tgtggttttc ctaactgtct gacttataat ttgcatacca ttaaataatg cataatatgg   3300

cacgccgaat cctgtttttc aaatatatgc ttttggtggc taccatgcag gatttgaatt   3360

tgtcttttaa tttagcttag gaaagaacat cactgggcga gcggtaaatc ctaaagaagg   3420

tgataaatgt cagtagtttc ttattaaata ttctaatttt aggttcccaa accttcagga   3480

aatatatctt aatgcagaca aacaaacata aaacttcttt agtacttaca tcaggaaatt   3540

tggggcagat tttagagggg ggaaattata ggaggaaaga agttcacatc agaacagaca   3600

atcacagcaa tgctctattc cttagaaatt agtgccacaa ataagttaca tctacaaaca   3660

ggtggtaaaa attctttctg gcccagttaa tttgcacaga acttttctca gtttggtatt   3720

ttttactgct tggagatcca gaagagaatt agaaacaaca tagcaaatta aaataggttt   3780

gtcaataata gagctcagac acctgtgtgc tgtagattca catacaggcc gtgaacctaa   3840

gtggggaaaa tcctacctat ccaccttctg gctagattac ctagcttagt gaaaagatag   3900

ccaaataatt ggcatgtgaa ttatttcctg cttattcata ataaataatg actgtcta     3958


<210>  514
<211>  773
<212>  PRT
<213>  Homosapiens

<400>  514

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys 
                165                 170                 175     


Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr 
        195                 200                 205             


Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln 
    210                 215                 220                 


Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu 
225                 230                 235                 240 


Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu 
                245                 250                 255     


Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His 
            260                 265                 270         


His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala 
        275                 280                 285             


Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn 
    290                 295                 300                 


Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg 
305                 310                 315                 320 


Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro 
                325                 330                 335     


Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro 
            340                 345                 350         


Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro 
        355                 360                 365             


Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys 
    370                 375                 380                 


Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln 
                405                 410                 415     


Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser 
            420                 425                 430         


Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro 
        435                 440                 445             


Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys 
    450                 455                 460                 


Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro 
465                 470                 475                 480 


Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp 
            500                 505                 510         


Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser 
        515                 520                 525             


Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro 
    530                 535                 540                 


Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu 
545                 550                 555                 560 


Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala 
                565                 570                 575     


Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly 
            580                 585                 590         


Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser 
        595                 600                 605             


Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly 
    610                 615                 620                 


Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys 
625                 630                 635                 640 


Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr 
                645                 650                 655     


Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro 
            660                 665                 670         


Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser 
        675                 680                 685             


Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly 
    690                 695                 700                 


Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly 
705                 710                 715                 720 


Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys 
                725                 730                 735     


Glu Gly Arg Arg Ser Asp Thr Cys Ser Ser His Thr Pro Ile Arg Arg 
            740                 745                 750         


Ser Thr Gln Arg Ala Gln Asp Val Trp Gln Phe Ser Asp Gly Ser Ser 
        755                 760                 765             


Arg Ala Leu Lys Phe 
    770             


<210>  515
<211>  5963
<212>  DNA
<213>  Homosapiens

<400>  515
tttttttttt ttttttgctt aaaaaaaagc catgacggct ctcccacaat tcatcttccc     60

tgcgccatct ttgtattatt tctaatttat tttggatgtc aaaaggcact gatgaagata    120

ttttctctgg agtctccttc tttctaaccc ggctctcccg atgtgaaccg agccgtcgtc    180

cgcccgccgc cgccgccgcc gccgccgccg cccgccccgc agcccaccat gtctcgccgc    240

aagcaaggca aaccccagca cttaagcaaa cgggaattct cgcccgagcc tcttgaagcc    300

attcttacag atgatgaacc agaccacggc ccgttgggag ctccagaagg ggatcatgac    360

ctcctcacct gtgggcagtg ccagatgaac ttcccattgg gggacattct tatttttatc    420

gagcacaaac ggaaacaatg caatggcagc ctctgcttag aaaaagctgt ggataagcca    480

ccttcccctt caccaatcga gatgaaaaaa gcatccaatc ccgtggaggt tggcatccag    540

gtcacgccag aggatgacga ttgtttatca acgtcatcta gaggaatttg ccccaaacag    600

gaacacatag cagataaact tctgcactgg aggggcctct cctcccctcg ttctgcacat    660

ggagctctaa tccccacgcc tgggatgagt gcagaatatg ccccgcaggg tatttgtaaa    720

gatgagccca gcagctacac atgtacaact tgcaaacagc cattcaccag tgcatggttt    780

ctcttgcaac acgcacagaa cactcatgga ttaagaatct acttagaaag cgaacacgga    840

agtcccctga ccccgcgggt tggtatccct tcaggactag gtgcagaatg tccttcccag    900

ccacctctcc atgggattca tattgcagac aataacccct ttaacctgct aagaatacca    960

ggatcagtat cgagagaggc ttccggcctg gcagaagggc gctttccacc cactcccccc   1020

ctgtttagtc caccaccgag acatcacttg gacccccacc gcatagagcg cctgggggcg   1080

gaagagatgg ccctggccac ccatcacccg agtgcctttg acagggtgct gcggttgaat   1140

ccaatggcta tggagcctcc cgccatggat ttctctagga gacttagaga gctggcaggg   1200

aacacgtcta gcccaccgct gtccccaggc cggcccagcc ctatgcaaag gttactgcaa   1260

ccattccagc caggtagcaa gccgcccttc ctggcgacgc cccccctccc tcctctgcaa   1320

tccgcccctc ctccctccca gcccccggtc aagtccaagt catgcgagtt ctgcggcaag   1380

acgttcaaat ttcagagcaa cctggtggtg caccggcgca gccacacggg cgagaagccc   1440

tacaagtgca acctgtgcga ccacgcgtgc acccaggcca gcaagctgaa gcgccacatg   1500

aagacgcaca tgcacaaatc gtcccccatg acggtcaagt ccgacgacgg tctctccacc   1560

gccagctccc cggaacccgg caccagcgac ttggtgggca gcgccagcag cgcgctcaag   1620

tccgtggtgg ccaagttcaa gagcgagaac gaccccaacc tgatcccgga gaacggggac   1680

gaggaggaag aggaggacga cgaggaagag gaagaagagg aggaagagga ggaggaggag   1740

ctgacggaga gcgagagggt ggactacggc ttcgggctga gcctggaggc ggcgcgccac   1800

cacgagaaca gctcgcgggg cgcggtcgtg ggcgtgggcg acgagagccg cgccctgccc   1860

gacgtcatgc agggcatggt gctcagctcc atgcagcact tcagcgaggc cttccaccag   1920

gtcctgggcg agaagcataa gcgcggccac ctggccgagg ccgagggcca cagggacact   1980

tgcgacgaag actcggtggc cggcgagtcg gaccgcatag acgatggcac tgttaatggc   2040

cgcggctgct ccccgggcga gtcggcctcg gggggcctgt ccaaaaagct gctgctgggc   2100

agccccagct cgctgagccc cttctctaag cgcatcaagc tcgagaagga gttcgacctg   2160

cccccggccg cgatgcccaa cacggagaac gtgtactcgc agtggctcgc cggctacgcg   2220

gcctccaggc agctcaaaga tcccttcctt agcttcggag actccagaca atcgcctttt   2280

gcctcctcgt cggagcactc ctcggagaac gggagcttgc gcttctccac accgcccggg   2340

gagctggacg gagggatctc ggggcgcagc ggcacgggaa gtggagggag cacgccccat   2400

attagtggtc cgggcccggg caggcccagc tcaaaagagg gcagacgcag cgacacttgt   2460

gagtactgtg ggaaagtctt caagaactgt agcaatctca ctgtccacag gagaagccac   2520

acgggcgaaa ggccttataa atgcgagctg tgcaactatg cctgtgccca gagtagcaag   2580

ctcaccaggc acatgaaaac gcatggccag gtggggaagg acgtttacaa atgtgaaatt   2640

tgtaagatgc cttttagcgt gtacagtacc ctggagaaac acatgaaaaa atggcacagt   2700

gatcgagtgt tgaataatga tataaaaact gaatagaggt atattaatac ccctccctca   2760

ctcccacctg acaccccctt tttcaccact ccccttcccc atcgccctcc agccccactc   2820

cctgtaggat ttttttctag tcccatgtga tttaaacaaa caaacaaaca aacagaagta   2880

acgaagctaa gaatatgaga gtgcttgtca ccagcacacc tgtttttttt ctttttcttt   2940

ttcttttttc tttttccttt tttttttttt tcctttatgt tctcaccgtt tgaatgcatg   3000

atctgtatgg ggcaatacta ttgcatttta cgcaaacttt gagcctttct cttgtgcaat   3060

aatttacatg ttgtgtatgt ttttttttaa acttagacag catgtatggt atgttatggc   3120

tattttaaat tgtccctaat tcgttgctga gcaaacatgt tgctgtttcc agttccgttc   3180

tgagagaaaa agagagagag agagaaaaag accatgctgc atacattctg taatacatat   3240

catgtacagt tttattttat aacgtgagga ggaaaaacag tctttggatt aaccctctat   3300

agacagaata gatagcactg aaaaaaaatc tctatgagct aaatgtctgt ctctaaaggg   3360

ttaaatgtat caattggaaa ggaagaaaaa aggccttgaa ttgacaaatt aacagaaaaa   3420

cagaacaagt ttattctatc atttggtttt aaaatatgag tgccttggat ctattaaaac   3480

cacatcgatg gttctttcta cttgttataa acttgtagct taattcagca ttgggtgagg   3540

taataaacct taggaactag catataattc tatattgtat ttctcacaac aatggctacc   3600

taaaaagatg acccattatg tcctagttaa tcatcatttt tcctttagtt taattttata   3660

aacaaaactg attataccag tataaaagct actttgctcc tggtgagagc ttaaaagaaa   3720

tgggctgttt tgcccaaagt tttatttttt ttaaacaatg attaaattga atgtgtaatg   3780

tgcaaaagcc ctggaacgca attaaataca ctagtaagga gttcatttta tgaagatatt   3840

tgctttaata atgtcttttt aaaaatactg gcaccaaaag aaatagatcc agatctactt   3900

ggttgtcaag tggacaatca aatgataaac tttaagacct tgtataccat attgaaagga   3960

agaggctgac aataaggttt gacagagggg aacagaagaa aataatatga tttattagca   4020

caacgtggta ctatttgcca tttaaaacta gaacaggtat ataagctaat attgatacaa   4080

tgatgattaa ctatgaattc ttaagacttg catttaaatg tgacattctt aaaaaaagaa   4140

gagaaagaat tttaagagta gcagtatata tgtctgtgct ccctaaaagt tgtacttcat   4200

ttcttttcca tacactgtgt gctatttgtg ttaacatgga agaggattca ttgtttttat   4260

ttttattttt ttaatttttt cttttttatt aagctagcat ctgccccagt tggtgttcaa   4320

atagcacttg actctgcctg tgatatctgt atcttttctc taatcagaga tacagaggtt   4380

gagtataaaa taaacctgct cagataggac aattaagtgc actgtacaat tttcccagtt   4440

tacaggtcta tacttaaggg aaaagttgca agaatgctga aaaaaaattg aacacaatct   4500

cattgaggag cattttttaa aaactaaaaa aaaaaaaact ttgccagcca tttacttgac   4560

tattgagctt acttacttgg acgcaacatt gcaagcgctg tgaatggaaa cagaatacac   4620

ttaacataga aatgaatgat tgctttcgct tctacagtgc aaggattttt ttgtacaaaa   4680

cttttttaaa tataaatgtt aagaaaaatt ttttttaaaa aacacttcat tatgtttagg   4740

ggggaactgc attttagggt tccattgtct tggtggtgtt acaagacttg ttatccattt   4800

aaaaatggta gtggaaattc tatgccttgg atacacaccg ctcttcaggt tgtaaaaaaa   4860

aaaaacatac attggggaaa ggtttaagat tatatagtac ttaaatatag gaaaatgcac   4920

actcatgttg attcctatgc taaaatacat ttatggtctt ttttctgtat ttctagaatg   4980

gtatttgaat taaatgttca tctagtgtta ggcactatag tatttatatt gaagcttgta   5040

tttttaactg ttgcttgttc tcttaaaagg tatcaatgta ccttttttgg tagtggaaaa   5100

aaaaaagaca ggctgccaca gtatattttt ttaatttggc aggataatat agtgcaaatt   5160

atttgtatgc ttcaaaaaaa aaaaaaagag agaaacaaaa aagtgtgaca ttacagatga   5220

gaagccatat aatggcggtt tgggggagcc tgctagaatg tcacatggat ggctgtcata   5280

ggggttgtac atatcctttt ttgttccttt ttcctgctgc catactgtat gcagtactgc   5340

aagctaataa cgttggtttg ttatgtagtg tgctttttgt ccctttcctt ctatcaccct   5400

acattccagc atcttacctt catatgcagt aaaagaaaga aagaaaaaaa aaggaaaaaa   5460

aaaaaaaaac caatgttttg cagttttttt cattgccaaa aactaaatgg tgctttatat   5520

ttagattgga aagaatttca tatgcaaagc atattaaaga gaaagcccgc tttagtcaat   5580

acttttttgt aaatggcaat gcagaatatt ttgttattgg ccttttctat tcctgtaatg   5640

aaagctgttt gtcgtaactt gaaattttat cttttactat gggagtcact atttattatt   5700

gcttatgtgc cctgttcaaa acagaggcac ttaatttgat cttttatttt tctttgtttt   5760

tatttttttt tttatttaga tgaccaaagg tcattacaac ctggcttttt attgtatttg   5820

tttctggtct ttgttaagtt ctattggaaa aaccactgtc tgtgtttttt tggcagttgt   5880

ctgcattaac ctgttcatac acccattttg tccctttatt gaaaaaataa aaaaaattaa   5940

aagtacaaaa aaaaaaaaaa aaa                                           5963


<210>  516
<211>  835
<212>  PRT
<213>  Homosapiens

<400>  516

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys 
                165                 170                 175     


Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr 
        195                 200                 205             


Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln 
    210                 215                 220                 


Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu 
225                 230                 235                 240 


Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu 
                245                 250                 255     


Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His 
            260                 265                 270         


His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala 
        275                 280                 285             


Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn 
    290                 295                 300                 


Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg 
305                 310                 315                 320 


Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro 
                325                 330                 335     


Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro 
            340                 345                 350         


Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro 
        355                 360                 365             


Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys 
    370                 375                 380                 


Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln 
                405                 410                 415     


Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser 
            420                 425                 430         


Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro 
        435                 440                 445             


Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys 
    450                 455                 460                 


Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro 
465                 470                 475                 480 


Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp 
            500                 505                 510         


Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser 
        515                 520                 525             


Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro 
    530                 535                 540                 


Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu 
545                 550                 555                 560 


Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala 
                565                 570                 575     


Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly 
            580                 585                 590         


Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser 
        595                 600                 605             


Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly 
    610                 615                 620                 


Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys 
625                 630                 635                 640 


Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr 
                645                 650                 655     


Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro 
            660                 665                 670         


Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser 
        675                 680                 685             


Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly 
    690                 695                 700                 


Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly 
705                 710                 715                 720 


Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys 
                725                 730                 735     


Glu Gly Arg Arg Ser Asp Thr Cys Glu Tyr Cys Gly Lys Val Phe Lys 
            740                 745                 750         


Asn Cys Ser Asn Leu Thr Val His Arg Arg Ser His Thr Gly Glu Arg 
        755                 760                 765             


Pro Tyr Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys 
    770                 775                 780                 


Leu Thr Arg His Met Lys Thr His Gly Gln Val Gly Lys Asp Val Tyr 
785                 790                 795                 800 


Lys Cys Glu Ile Cys Lys Met Pro Phe Ser Val Tyr Ser Thr Leu Glu 
                805                 810                 815     


Lys His Met Lys Lys Trp His Ser Asp Arg Val Leu Asn Asn Asp Ile 
            820                 825                 830         


Lys Thr Glu 
        835 


<210>  517
<211>  3976
<212>  DNA
<213>  Homosapiens

<400>  517
tttttttttt ttttttgctt aaaaaaaagc catgacggct ctcccacaat tcatcttccc     60

tgcgccatct ttgtattatt tctaatttat tttggatgtc aaaaggcact gatgaagata    120

ttttctctgg agtctccttc tttctaaccc ggctctcccg atgtgaaccg agccgtcgtc    180

cgcccgccgc cgccgccgcc gccgccgccg cccgccccgc agcccaccat gtctcgccgc    240

aagcaaggca aaccccagca cttaagcaaa cgggaattct cgcccgagcc tcttgaagcc    300

attcttacag atgatgaacc agaccacggc ccgttgggag ctccagaagg ggatcatgac    360

ctcctcacct gtgggcagtg ccagatgaac ttcccattgg gggacattct tatttttatc    420

gagcacaaac ggaaacaatg caatggcagc ctctgcttag aaaaagctgt ggataagcca    480

ccttcccctt caccaatcga gatgaaaaaa gcatccaatc ccgtggaggt tggcatccag    540

gtcacgccag aggatgacga ttgtttatca acgtcatcta gaggaatttg ccccaaacag    600

gaacacatag cagataaact tctgcactgg aggggcctct cctcccctcg ttctgcacat    660

ggagctctaa tccccacgcc tgggatgagt gcagaatatg ccccgcaggg tatttgtaaa    720

gatgagccca gcagctacac atgtacaact tgcaaacagc cattcaccag tgcatggttt    780

ctcttgcaac acgcacagaa cactcatgga ttaagaatct acttagaaag cgaacacgga    840

agtcccctga ccccgcgggt tggtatccct tcaggactag gtgcagaatg tccttcccag    900

ccacctctcc atgggattca tattgcagac aataacccct ttaacctgct aagaatacca    960

ggatcagtat cgagagaggc ttccggcctg gcagaagggc gctttccacc cactcccccc   1020

ctgtttagtc caccaccgag acatcacttg gacccccacc gcatagagcg cctgggggcg   1080

gaagagatgg ccctggccac ccatcacccg agtgcctttg acagggtgct gcggttgaat   1140

ccaatggcta tggagcctcc cgccatggat ttctctagga gacttagaga gctggcaggg   1200

aacacgtcta gcccaccgct gtccccaggc cggcccagcc ctatgcaaag gttactgcaa   1260

ccattccagc caggtagcaa gccgcccttc ctggcgacgc cccccctccc tcctctgcaa   1320

tccgcccctc ctccctccca gcccccggtc aagtccaagt catgcgagtt ctgcggcaag   1380

acgttcaaat ttcagagcaa cctggtggtg caccggcgca gccacacggg cgagaagccc   1440

tacaagtgca acctgtgcga ccacgcgtgc acccaggcca gcaagctgaa gcgccacatg   1500

aagacgcaca tgcacaaatc gtcccccatg acggtcaagt ccgacgacgg tctctccacc   1560

gccagctccc cggaacccgg caccagcgac ttggtgggca gcgccagcag cgcgctcaag   1620

tccgtggtgg ccaagttcaa gagcgagaac gaccccaacc tgatcccgga gaacggggac   1680

gaggaggaag aggaggacga cgaggaagag gaagaagagg aggaagagga ggaggaggag   1740

ctgacggaga gcgagagggt ggactacggc ttcgggctga gcctggaggc ggcgcgccac   1800

cacgagaaca gctcgcgggg cgcggtcgtg ggcgtgggcg acgagagccg cgccctgccc   1860

gacgtcatgc agggcatggt gctcagctcc atgcagcact tcagcgaggc cttccaccag   1920

gtcctgggcg agaagcataa gcgcggccac ctggccgagg ccgagggcca cagggacact   1980

tgcgacgaag actcggtggc cggcgagtcg gaccgcatag acgatggcac tgttaatggc   2040

cgcggctgct ccccgggcga gtcggcctcg gggggcctgt ccaaaaagct gctgctgggc   2100

agccccagct cgctgagccc cttctctaag cgcatcaagc tcgagaagga gttcgacctg   2160

cccccggccg cgatgcccaa cacggagaac gtgtactcgc agtggctcgc cggctacgcg   2220

gcctccaggc agctcaaaga tcccttcctt agcttcggag actccagaca atcgcctttt   2280

gcctcctcgt cggagcactc ctcggagaac gggagcttgc gcttctccac accgcccggg   2340

gagctggacg gagggatctc ggggcgcagc ggcacgggaa gtggagggag cacgccccat   2400

attagtggtc cgggcccggg caggcccagc tcaaaagagg gcagacgcag cgacactttc   2460

tccaacctct ttctaggttc ttcacacacc cccattcggc gtagtaccca gagagctcaa   2520

gatgtgtggc agttttcgga tggaagctcg agagccctta agttctgaga aaatttgaag   2580

cccccagggg tggggtggac gcgtgccgcc cagtcgacgt cagcgtggtc tgtcatcctg   2640

ctagtttgtg atgttttctg acagtagcct ccaagaagcc gttgtgcgaa gacagagtcc   2700

tgcagagtcc ttccagccta ggcctgcagc gccattttat ttatattttt taataaaaag   2760

taaaaacaaa aaaacagacc cacattggaa cagtgaatca gtcccataga gagggcccgt   2820

ggaccatcgc tgtcatgagt gatgccctgg cccttctgaa accagccaac ctaattacct   2880

gtattgtgga aatgcgcatg agtccccaac cccttgtttc tatacattct atgttgtctt   2940

ttaaaaagtg tgcttaacat tgacacaata aatgttggag ctttaggtgg tgtttgcttg   3000

ttctttaatt tttaatgctt ataagacaat gaggctgctt atgattttgt acttctgtac   3060

ctgtttccta cagacaccca tcgggtgggt aggaggaaca gatttgagaa atgggcagga   3120

gatgtaggag gggaactagg ttaccgctta tcagatggca taaattttca aggagaatca   3180

aaatgcaaaa cttgggaata aatcatagca atatcataat taatgtagta gtaatattgc   3240

tgtttattaa tgctgaagtg tggttttcct aactgtctga cttataattt gcataccatt   3300

aaataatgca taatatggca cgccgaatcc tgtttttcaa atatatgctt ttggtggcta   3360

ccatgcagga tttgaatttg tcttttaatt tagcttagga aagaacatca ctgggcgagc   3420

ggtaaatcct aaagaaggtg ataaatgtca gtagtttctt attaaatatt ctaattttag   3480

gttcccaaac cttcaggaaa tatatcttaa tgcagacaaa caaacataaa acttctttag   3540

tacttacatc aggaaatttg gggcagattt tagagggggg aaattatagg aggaaagaag   3600

ttcacatcag aacagacaat cacagcaatg ctctattcct tagaaattag tgccacaaat   3660

aagttacatc tacaaacagg tggtaaaaat tctttctggc ccagttaatt tgcacagaac   3720

ttttctcagt ttggtatttt ttactgcttg gagatccaga agagaattag aaacaacata   3780

gcaaattaaa ataggtttgt caataataga gctcagacac ctgtgtgctg tagattcaca   3840

tacaggccgt gaacctaagt ggggaaaatc ctacctatcc accttctggc tagattacct   3900

agcttagtga aaagatagcc aaataattgg catgtgaatt atttcctgct tattcataat   3960

aaataatgac tgtcta                                                   3976


<210>  518
<211>  779
<212>  PRT
<213>  Homosapiens

<400>  518

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys 
                165                 170                 175     


Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr 
        195                 200                 205             


Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln 
    210                 215                 220                 


Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu 
225                 230                 235                 240 


Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu 
                245                 250                 255     


Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His 
            260                 265                 270         


His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala 
        275                 280                 285             


Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn 
    290                 295                 300                 


Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg 
305                 310                 315                 320 


Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro 
                325                 330                 335     


Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro 
            340                 345                 350         


Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro 
        355                 360                 365             


Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys 
    370                 375                 380                 


Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln 
                405                 410                 415     


Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser 
            420                 425                 430         


Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro 
        435                 440                 445             


Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys 
    450                 455                 460                 


Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro 
465                 470                 475                 480 


Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp 
            500                 505                 510         


Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser 
        515                 520                 525             


Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro 
    530                 535                 540                 


Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu 
545                 550                 555                 560 


Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala 
                565                 570                 575     


Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly 
            580                 585                 590         


Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser 
        595                 600                 605             


Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly 
    610                 615                 620                 


Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys 
625                 630                 635                 640 


Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr 
                645                 650                 655     


Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro 
            660                 665                 670         


Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser 
        675                 680                 685             


Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly 
    690                 695                 700                 


Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly 
705                 710                 715                 720 


Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys 
                725                 730                 735     


Glu Gly Arg Arg Ser Asp Thr Phe Ser Asn Leu Phe Leu Gly Ser Ser 
            740                 745                 750         


His Thr Pro Ile Arg Arg Ser Thr Gln Arg Ala Gln Asp Val Trp Gln 
        755                 760                 765             


Phe Ser Asp Gly Ser Ser Arg Ala Leu Lys Phe 
    770                 775                 


<210>  519
<211>  2358
<212>  DNA
<213>  Homosapiens

<400>  519
tttttttttt ttttttgctt aaaaaaaagc catgacggct ctcccacaat tcatcttccc     60

tgcgccatct ttgtattatt tctaatttat tttggatgtc aaaaggcact gatgaagata    120

ttttctctgg agtctccttc tttctaaccc ggctctcccg atgtgaaccg agccgtcgtc    180

cgcccgccgc cgccgccgcc gccgccgccg cccgccccgc agcccaccat gtctcgccgc    240

aagcaaggca aaccccagca cttaagcaaa cgggaattct cgcccgagcc tcttgaagcc    300

attcttacag atgatgaacc agaccacggc ccgttgggag ctccagaagg ggatcatgac    360

ctcctcacct gtgggcagtg ccagatgaac ttcccattgg gggacattct tatttttatc    420

gagcacaaac ggaaacaatg caatggcagc ctctgcttag aaaaagctgt ggataagcca    480

ccttcccctt caccaatcga gatgaaaaaa gcatccaatc ccgtggaggt tggcatccag    540

gtcacgccag aggatgacga ttgtttatca acgtcatcta gaggaatttg ccccaaacag    600

gaacacatag cagataaact tctgcactgg aggggcctct cctcccctcg ttctgcacat    660

ggagctctaa tccccacgcc tgggatgagt gcagaatatg ccccgcaggg tatttgtaaa    720

gatgagccca gcagctacac atgtacaact tgcaaacagc cattcaccag tgcatggttt    780

ctcttgcaac acgcacagaa cactcatgga ttaagaatct acttagaaag cgaacacgga    840

agtcccctga ccccgcgggt tcttcacaca cccccattcg gcgtagtacc cagagagctc    900

aagatgtgtg gcagttttcg gatggaagct cgagagccct taagttctga gaaaatttga    960

agcccccagg ggtggggtgg acgcgtgccg cccagtcgac gtcagcgtgg tctgtcatcc   1020

tgctagtttg tgatgttttc tgacagtagc ctccaagaag ccgttgtgcg aagacagagt   1080

cctgcagagt ccttccagcc taggcctgca gcgccatttt atttatattt tttaataaaa   1140

agtaaaaaca aaaaaacaga cccacattgg aacagtgaat cagtcccata gagagggccc   1200

gtggaccatc gctgtcatga gtgatgccct ggcccttctg aaaccagcca acctaattac   1260

ctgtattgtg gaaatgcgca tgagtcccca accccttgtt tctatacatt ctatgttgtc   1320

ttttaaaaag tgtgcttaac attgacacaa taaatgttgg agctttaggt ggtgtttgct   1380

tgttctttaa tttttaatgc ttataagaca atgaggctgc ttatgatttt gtacttctgt   1440

acctgtttcc tacagacacc catcgggtgg gtaggaggaa cagatttgag aaatgggcag   1500

gagatgtagg aggggaacta ggttaccgct tatcagatgg cataaatttt caaggagaat   1560

caaaatgcaa aacttgggaa taaatcatag caatatcata attaatgtag tagtaatatt   1620

gctgtttatt aatgctgaag tgtggttttc ctaactgtct gacttataat ttgcatacca   1680

ttaaataatg cataatatgg cacgccgaat cctgtttttc aaatatatgc ttttggtggc   1740

taccatgcag gatttgaatt tgtcttttaa tttagcttag gaaagaacat cactgggcga   1800

gcggtaaatc ctaaagaagg tgataaatgt cagtagtttc ttattaaata ttctaatttt   1860

aggttcccaa accttcagga aatatatctt aatgcagaca aacaaacata aaacttcttt   1920

agtacttaca tcaggaaatt tggggcagat tttagagggg ggaaattata ggaggaaaga   1980

agttcacatc agaacagaca atcacagcaa tgctctattc cttagaaatt agtgccacaa   2040

ataagttaca tctacaaaca ggtggtaaaa attctttctg gcccagttaa tttgcacaga   2100

acttttctca gtttggtatt ttttactgct tggagatcca gaagagaatt agaaacaaca   2160

tagcaaatta aaataggttt gtcaataata gagctcagac acctgtgtgc tgtagattca   2220

catacaggcc gtgaacctaa gtggggaaaa tcctacctat ccaccttctg gctagattac   2280

ctagcttagt gaaaagatag ccaaataatt ggcatgtgaa ttatttcctg cttattcata   2340

ataaataatg actgtcta                                                 2358


<210>  520
<211>  243
<212>  PRT
<213>  Homosapiens

<400>  520

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys 
                165                 170                 175     


Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr 
        195                 200                 205             


Pro Arg Val Leu His Thr Pro Pro Phe Gly Val Val Pro Arg Glu Leu 
    210                 215                 220                 


Lys Met Cys Gly Ser Phe Arg Met Glu Ala Arg Glu Pro Leu Ser Ser 
225                 230                 235                 240 


Glu Lys Ile 
            


<210>  521
<211>  3853
<212>  DNA
<213>  Homosapiens

<400>  521
gagcggcttc gcttccagcc ccgagtgagg cggagaccca ggcgggcggg cagagcaggc     60

ggcaccgcac ctcggccaga ggcggctgca gcagctgctg cccttgtccc tgccgccgcc    120

tctccagtcc cttctgtgat taccactcca gctgctggga acgggcgaga aagaggagga    180

ggcgagaaac tcccaccgac ccacagaggg agcatgactt cggcaacttc acctatcatt    240

ctgaaatggg accccaaaag tttggaaatc cggacgctaa cagtggaaag gctgttggag    300

ccacttgtta cacaggtgac tacacttgtc aacacaagca acaaaggccc atctggtaaa    360

aagaaaggga ggtcaaagaa agcccatgta ctagctgcct ctgtagagca agccactcag    420

aatttcctgg aaaagggtga acagatcgct aaggagagtc aagatctcaa agaagagttg    480

gtggctgctg tagaggatgt gcgcaaacaa ggtgagacga tgcggatcgc ctcctccgag    540

tttgcagatg acccttgctc gtcggtaaag cgcggcacca tggtacgggc ggcaagggct    600

ttgctctccg cggtgacacg cttactcatc ctggcggaca tggcagatgt catgagactt    660

ttatcccatc tgaaaattgt ggaagaggcc ctggaagctg tcaaaaatgc tacaaatgag    720

caagaccttg caaaccgttt taaagagttt gggaaagaga tggtgaaact taactatgta    780

gcagcaagaa gacaacagga gctgaaggat cctcactgtc gggatgagat ggcagccgcc    840

cgaggggctc tgaagaagaa tgccacaatg ctgtacacgg cctctcaagc atttctccgc    900

cacccagatg tcgccgctac gagagccaac cgagattatg tgttcaaaca agtccaggag    960

gccatcgccg gcatctccaa tgctgctcaa gctacctcgc ccactgacga agccaagggc   1020

cacacgggca tcggcgagct ggctgcggct cttaatgagt ttgacaataa gattatcctg   1080

gaccccatga cgttcagcga ggccaggttc cggccgtccc tggaggagag gctggagagc   1140

atcatcagcg gcgcagcgct gatggccgac tcctcctgca cgcgagacga ccggcgcgag   1200

aggatcgtgg cggagtgcaa cgccgtgcgg caggcgctcc aggacctgct cagcgagtac   1260

atgaataata ctggaaggaa agaaaaagga gatcctctca acattgcgat tgataagatg   1320

actaagaaaa caagagatct aaggagacag cttcggaaag cagtgatgga tcacatatct   1380

gactctttcc tggaaaccaa tgttcctttg ctagttctca ttgaggctgc aaagagcgga   1440

aatgaaaagg aagtgaaaga atatgcccaa gttttccgtg agcatgccaa caaactggta   1500

gaggttgcca atttggcctg ttccatctcc aacaatgaag aaggggtgaa attagttcgg   1560

atggcagcca cccagattga cagcctgtgt ccccaggtca tcaatgccgc tctgacactg   1620

gctgcccggc cacagagcaa agttgctcag gataacatgg acgtcttcaa agaccagtgg   1680

gagaagcagg tccgagtgtt gacagaggcc gtggatgaca tcacctcagt ggatgacttc   1740

ctctctgtct cagaaaatca catcttggag gatgtgaaca agtgtgtgat agccctccaa   1800

gagggcgatg tggacactct ggaccggact gcaggggcca tcaggggccg ggcagctcga   1860

gtcatacaca tcatcaatgc tgagatggag aactatgaag ctggggttta tactgagaag   1920

gtgttggaag ctacaaaatt gctttctgaa acagtgatgc cacgcttcgc tgaacaagta   1980

gaggttgcca ttgaagccct gagtgccaac gttcctcaac cgtttgagga gaatgagttc   2040

atcgatgcct ctcgcctggt gtatgatggc gttcgggaca tcagaaaggc tgtgctgatg   2100

atcaggaccc cagaagaact agaggatgat tctgactttg agcaggaaga ttatgatgtg   2160

cgtagcagga caagtgttca gactgaggat gaccagctca ttgcagggca gagcgcacgg   2220

gccatcatgg cgcaactacc gcaggaggag aaggcaaaaa tagctgagca ggtggagata   2280

ttccatcaag agaaaagcaa gctggatgca gaagtggcca aatgggacga cagcggcaat   2340

gatatcattg tactggccaa gcagatgtgt atgatcatga tggaaatgac agacttcaca   2400

agaggcaaag gcccattgaa aaatacatct gatgtcatta atgctgccaa gaaaattgcc   2460

gaagcaggtt ctcgaatgga caaattagct cgtgctgtgg ctgatcagtg tcctgattca   2520

gcatgtaagc aggatttatt agcctacctt caacgaattg ccttgtattg ccatcagctt   2580

aatatctgca gcaaggtgaa ggcagaagtg cagaatctgg gaggagagct cattgtgtca   2640

gggctggaca gtgccacatc gcttatccag gcagctaaaa acctgatgaa tgctgttgtc   2700

ctcacggtga aagcatccta tgtggcctca accaaatacc agaaggtcta tgggacagca   2760

gctgtcaact cacctgttgt gtcttggaag atgaaggctc cagagaagaa gccccttgtg   2820

aagagagaaa agcctgaaga attccagaca cgagttcgac gaggttctca gaagaaacac   2880

atttcgcctg tacaggcttt aagtgaattc aaagcaatgg attccttcta ggacgatagg   2940

ttttaacaag aaagcttttt ctttcttttc tttctttctt tttcttttta attccatttt   3000

tgtatgcata cctgccagct cgtatgcctc tggcatgggg aaattaaggg aacagtgtct   3060

gtttgcatgt aagatgagat gagatcaata ctactgatcc atctgtagcc tgggaaggag   3120

acaggacatt cctgtactaa ggtggcacag agctgtcctt tgcaacattc tcataaaatt   3180

gggcacagag ttcgcattgg cgcaatattt atgggagtgg gagggatggg gaaaataaac   3240

ttaactctac aaaagcaaac tctaatgcat gcaagaatca ttaggttggc aggtatatgc   3300

ataagtgaaa aatctggaag tgtaatggta gaacataaaa cttgtattgc ttctgtttca   3360

gtgcaaaaat gtactagcca atacgcttaa gtgtgtggcc catgaattga acaatttaac   3420

cttgaagtct atatccgtga tattatgtcg atttttaact gaggggaaat taactagtcc   3480

agcctaaaat gcttctttta atctgcattc tgtttcctct tctagttgtg ccattactag   3540

tgatcatgtt tttttccccc ctttaatgaa aacaataaac atctatttga gacaattaaa   3600

atccttctgg gggcactgga agcacaatac ggtgaccaat cttgctttca tttttttttc   3660

tttttaattt gaaccatgat tttgctagaa atagaaggcc cagtggtgga atattagagg   3720

gaaggaaact gacaacgtgt gaaagttaga ggcaaataca taggtgtagc ttggagtgct   3780

ggtatctaat ataccattgt attcactaac taactcaaaa taaacacatt taatcttgaa   3840

aaaaaaaaaa aaa                                                      3853


<210>  522
<211>  905
<212>  PRT
<213>  Homosapiens

<400>  522

Met Thr Ser Ala Thr Ser Pro Ile Ile Leu Lys Trp Asp Pro Lys Ser 
1               5                   10                  15      


Leu Glu Ile Arg Thr Leu Thr Val Glu Arg Leu Leu Glu Pro Leu Val 
            20                  25                  30          


Thr Gln Val Thr Thr Leu Val Asn Thr Ser Asn Lys Gly Pro Ser Gly 
        35                  40                  45              


Lys Lys Lys Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser Val 
    50                  55                  60                  


Glu Gln Ala Thr Gln Asn Phe Leu Glu Lys Gly Glu Gln Ile Ala Lys 
65                  70                  75                  80  


Glu Ser Gln Asp Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp Val 
                85                  90                  95      


Arg Lys Gln Gly Glu Thr Met Arg Ile Ala Ser Ser Glu Phe Ala Asp 
            100                 105                 110         


Asp Pro Cys Ser Ser Val Lys Arg Gly Thr Met Val Arg Ala Ala Arg 
        115                 120                 125             


Ala Leu Leu Ser Ala Val Thr Arg Leu Leu Ile Leu Ala Asp Met Ala 
    130                 135                 140                 


Asp Val Met Arg Leu Leu Ser His Leu Lys Ile Val Glu Glu Ala Leu 
145                 150                 155                 160 


Glu Ala Val Lys Asn Ala Thr Asn Glu Gln Asp Leu Ala Asn Arg Phe 
                165                 170                 175     


Lys Glu Phe Gly Lys Glu Met Val Lys Leu Asn Tyr Val Ala Ala Arg 
            180                 185                 190         


Arg Gln Gln Glu Leu Lys Asp Pro His Cys Arg Asp Glu Met Ala Ala 
        195                 200                 205             


Ala Arg Gly Ala Leu Lys Lys Asn Ala Thr Met Leu Tyr Thr Ala Ser 
    210                 215                 220                 


Gln Ala Phe Leu Arg His Pro Asp Val Ala Ala Thr Arg Ala Asn Arg 
225                 230                 235                 240 


Asp Tyr Val Phe Lys Gln Val Gln Glu Ala Ile Ala Gly Ile Ser Asn 
                245                 250                 255     


Ala Ala Gln Ala Thr Ser Pro Thr Asp Glu Ala Lys Gly His Thr Gly 
            260                 265                 270         


Ile Gly Glu Leu Ala Ala Ala Leu Asn Glu Phe Asp Asn Lys Ile Ile 
        275                 280                 285             


Leu Asp Pro Met Thr Phe Ser Glu Ala Arg Phe Arg Pro Ser Leu Glu 
    290                 295                 300                 


Glu Arg Leu Glu Ser Ile Ile Ser Gly Ala Ala Leu Met Ala Asp Ser 
305                 310                 315                 320 


Ser Cys Thr Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu Cys Asn 
                325                 330                 335     


Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met Asn Asn 
            340                 345                 350         


Thr Gly Arg Lys Glu Lys Gly Asp Pro Leu Asn Ile Ala Ile Asp Lys 
        355                 360                 365             


Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
    370                 375                 380                 


Met Asp His Ile Ser Asp Ser Phe Leu Glu Thr Asn Val Pro Leu Leu 
385                 390                 395                 400 


Val Leu Ile Glu Ala Ala Lys Ser Gly Asn Glu Lys Glu Val Lys Glu 
                405                 410                 415     


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Val Glu Val Ala 
            420                 425                 430         


Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val 
        435                 440                 445             


Arg Met Ala Ala Thr Gln Ile Asp Ser Leu Cys Pro Gln Val Ile Asn 
    450                 455                 460                 


Ala Ala Leu Thr Leu Ala Ala Arg Pro Gln Ser Lys Val Ala Gln Asp 
465                 470                 475                 480 


Asn Met Asp Val Phe Lys Asp Gln Trp Glu Lys Gln Val Arg Val Leu 
                485                 490                 495     


Thr Glu Ala Val Asp Asp Ile Thr Ser Val Asp Asp Phe Leu Ser Val 
            500                 505                 510         


Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile Ala Leu 
        515                 520                 525             


Gln Glu Gly Asp Val Asp Thr Leu Asp Arg Thr Ala Gly Ala Ile Arg 
    530                 535                 540                 


Gly Arg Ala Ala Arg Val Ile His Ile Ile Asn Ala Glu Met Glu Asn 
545                 550                 555                 560 


Tyr Glu Ala Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr Lys Leu 
                565                 570                 575     


Leu Ser Glu Thr Val Met Pro Arg Phe Ala Glu Gln Val Glu Val Ala 
            580                 585                 590         


Ile Glu Ala Leu Ser Ala Asn Val Pro Gln Pro Phe Glu Glu Asn Glu 
        595                 600                 605             


Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Val Arg Asp Ile Arg 
    610                 615                 620                 


Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Glu Asp Asp Ser 
625                 630                 635                 640 


Asp Phe Glu Gln Glu Asp Tyr Asp Val Arg Ser Arg Thr Ser Val Gln 
                645                 650                 655     


Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile Met 
            660                 665                 670         


Ala Gln Leu Pro Gln Glu Glu Lys Ala Lys Ile Ala Glu Gln Val Glu 
        675                 680                 685             


Ile Phe His Gln Glu Lys Ser Lys Leu Asp Ala Glu Val Ala Lys Trp 
    690                 695                 700                 


Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys Met 
705                 710                 715                 720 


Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu Lys 
                725                 730                 735     


Asn Thr Ser Asp Val Ile Asn Ala Ala Lys Lys Ile Ala Glu Ala Gly 
            740                 745                 750         


Ser Arg Met Asp Lys Leu Ala Arg Ala Val Ala Asp Gln Cys Pro Asp 
        755                 760                 765             


Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala Leu 
    770                 775                 780                 


Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val Gln 
785                 790                 795                 800 


Asn Leu Gly Gly Glu Leu Ile Val Ser Gly Leu Asp Ser Ala Thr Ser 
                805                 810                 815     


Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Leu Thr Val 
            820                 825                 830         


Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Val Tyr Gly Thr 
        835                 840                 845             


Ala Ala Val Asn Ser Pro Val Val Ser Trp Lys Met Lys Ala Pro Glu 
    850                 855                 860                 


Lys Lys Pro Leu Val Lys Arg Glu Lys Pro Glu Glu Phe Gln Thr Arg 
865                 870                 875                 880 


Val Arg Arg Gly Ser Gln Lys Lys His Ile Ser Pro Val Gln Ala Leu 
                885                 890                 895     


Ser Glu Phe Lys Ala Met Asp Ser Phe 
            900                 905 


<210>  523
<211>  4718
<212>  DNA
<213>  Homosapiens

<400>  523
gaggggggcg ggtccgggag gctgtgcgtg tcttgtgaga gctcttgaac caagtcagcg     60

ctggagtcgg ctaggcggct ggaaacggcg gctgccgccg gtgactcagg gaggcgggag    120

gcgggggagg agctcttcct gcaggcgtgg aaaccatggt gctcacgctc ggagaaagtt    180

ggccggtatt ggtggggagg aggtttctca gtctgtccgc agccgacggc agcgatggca    240

gccacgacag ctgggacgtg gagcgcgtcg ccgagtggcc ctggctctcc gggaccattc    300

gagctgtttc ccacaccgac gttaccaaga aggatctgaa ggtgtgtgtg gaatttgatg    360

gggaatcttg gaggaaaaga agatggatag aagtctacag ccttctaagg agagcatttt    420

tagtagaaca taatttggtt ttagctgaac gaaagtcacc tgaaatttct gaacgaattg    480

tacagtggcc tgcaataacg tacaaacctc tgttggacaa agctggtttg ggatccataa    540

cttctgttcg ctttctggga gatcaacaaa gagtatttct ttctaaagac cttttgaagc    600

ctatacagga tgtaaacagt cttcgacttt ctcttacgga taatcagatt gtcagtaaag    660

aatttcaagc tttgattgtg aagcatttag atgaaagcca tcttttaaaa ggtgacaaaa    720

acttagttgg ttcagaagta aaaatttata gcttggaccc atctactcag tggttttcag    780

caaccgttat aaatggaaac ccagcatcaa aaactcttca agtcaactgt gaggagattc    840

cagcactgaa aattgttgat ccgtcactga ttcatgttga agttgtacac gataaccttg    900

tgacatgtgg taattctgca agaattggag ctgtaaaacg caagtcttct gagaataatg    960

gaaccctggt ttccaaacaa gcaaaatctt gctctgaggc ctctcccagt atgtgtcctg   1020

tgcagtctgt acctacaaca gtttttaagg agatactgct tggctgtact gcggcaactc   1080

cacctagtaa ggacccaaga cagcaaagta ctccccaggc tgccaactct ccacctaacc   1140

ttggagcaaa aattcctcaa ggatgtcata aacaaagttt accagaggaa atttcttcct   1200

gtctaaatac aaagtctgaa gctctgagaa caaaaccaga tgtctgcaaa gcagggttgc   1260

tctcaaagtc ctctcagatt ggaactggag acttgaaaat tctgactgag ccaaaaggca   1320

gctgtactca gcctaagaca aacactgatc aggaaaacag attggagtct gttccacaag   1380

cattgactgg ccttcctaag gagtgcttac ctacaaaggc ttcttctaag gcagaattgg   1440

aaattgccaa tcctcctgaa ctgcagaagc acctagaaca tgcaccttcc ccatcggatg   1500

tttcaaatgc accagaagtg aaagcaggtg tcaatagtga tagccctaat aactgttcag   1560

gaaaaaaggt agaaccttca gctttagctt gccgatcaca gaatttaaag gaatcttcag   1620

taaaagtaga taatgaaagc tgttgttcaa gaagcaacaa taaaatccag aatgccccat   1680

ccaggaagtc ggttttgaca gacccagcta aactcaaaaa gctgcaacag agtggcgagg   1740

ccttcgtaca ggatgattct tgtgtgaaca tcgtggcaca gttgcctaaa tgccgagagt   1800

gtcgcttgga cagtctccgc aaggataagg agcaacagaa ggactcacct gtgttttgcc   1860

gcttctttca cttcaggagg ttacaattca acaaacatgg tgtgttgcgg gtagaaggct   1920

tcttaacacc aaacaagtat gacaatgaag caattggctt gtggttacct ttaaccaaaa   1980

acgttgtggg gattgatttg gacacagcaa agtacatctt ggccaacatt ggagaccact   2040

tctgtcaaat ggtgatttct gaaaaggaag ctatgtcaac tattgagcca cacagacagg   2100

ttgcttggaa gcgagctgtc aaaggtgttc gagaaatgtg tgatgtgtgc gacaccacca   2160

tcttcaacct gcactgggtg tgtcctcggt gtgggtttgg agtatgtgtg gactgctacc   2220

ggatgaagag aaagaattgc caacagggtg ctgcttacaa gactttctct tggctaaaat   2280

gtgtgaagag tcagatacat gaaccagaga acttaatgcc cacacagatc attcctggaa   2340

aagcactcta tgatgttgga gacattgttc attctgtaag agcgaaatgg ggaataaagg   2400

caaactgccc ttgttcaaac aggcaattca aactcttttc aaagccagcc tcaaaggaag   2460

acctaaaaca gacttcttta gctggagaaa aaccgactct tggtgcagtg ctccagcaga   2520

atccctcagt gttggagcca gcagctgtgg gtggggaagc agcctccaag ccagccggca   2580

gcatgaagcc tgcctgtcca gccagcacat ctcctctaaa ctggctggcc gacctaacca   2640

gcgggaatgt caacaaggaa aacaaggaaa aacaaccaac aatgccaatt ttaaagaatg   2700

aaatcaaatg ccttccaccc ctcccacctt taagcaaatc cagcacagtc ctccatacgt   2760

ttaacagcac aattttgaca cccgtaagca acaacaattc tggtttcctc cggaatctct   2820

tgaattcttc tacaggaaag acagaaaatg gactcaagaa tacaccaaaa atccttgatg   2880

acatctttgc ctctttggtg caaaataaga cgacttctga tttatctaag aggcctcaag   2940

gactaaccat caagcccagc attctgggct ttgacactcc tcactattgg ctttgtgata   3000

atcgcttgct gtgcttgcaa gaccccaaca ataagagcaa ctggaatgtg tttagggagt   3060

gctggaaaca agggcagcca gtgatggtgt ctggagtgca tcataaattg aactctgaac   3120

tttggaaacc tgaatccttc aggaaagagt ttggtgagca ggaagtagac ctagttaatt   3180

gtaggaccaa tgaaatcatc acaggagcca cagtaggaga cttctgggat ggatttgaag   3240

atgttccaaa tcgtttgaaa aatgaaaaag aaccaatggt gttgaaactt aaggactggc   3300

caccaggaga agattttaga gatatgatgc cttccaggtt tgatgatctg atggccaaca   3360

ttccactgcc cgagtacaca aggcgagatg gcaaactgaa tttggcctct aggctgccaa   3420

actactttgt tcggccagat ctgggcccca agatgtataa tgcttatgga ttaatcactc   3480

ctgaagatcg gaaatatgga acaacaaatc ttcacttaga tgtatctgat gcagctaatg   3540

tcatggtcta tgtgggaatt cccaaaggac agtgtgagca agaagaagaa gtccttaaga   3600

ccatccaaga tggagattct gacgaactca caataaagcg atttattgaa ggaaaagaga   3660

agccaggagc actgtggcac atatatgctg caaaggacac ggagaagata agggaatttc   3720

ttaaaaaggt atcagaagag caaggtcaag aaaacccagc agaccacgat cctattcatg   3780

atcaaagctg gtatttagac cgatcattaa gaaaacgtct tcatcaagag tatggagttc   3840

aaggctgggc tattgtacag tttcttgggg atgtggtgtt tatcccggca ggagctccac   3900

atcaggttca taacttatat agctgcatca aagtggctga agattttgtt tctccagagc   3960

atgttaaaca ctgcttctgg cttactcagg aattccgata tctgtcacag actcatacca   4020

atcacgaaga taaattacag gtgaagaatg ttatctacca tgcagtgaaa gatgcagttg   4080

ctatgctgaa agccagtgaa tccagttttg gcaaacctta atctccctgc acattggaaa   4140

tgaattacag gcagctgttc aaactcttca ggcaggattc ctgtggactt tgagattcat   4200

gttacctcat cttctttttt aaactgtacc caacttgtga gggtactctg tctaatgtat   4260

atttctagtg tttacagaca gtaaatgtgt atatgtagta actatttaca gaacatgcat   4320

ccttaaactg tgacttctca cctagtgcag aacttttacc aggctgtaaa agcaaaacct   4380

cgtatcagct ctggaacaat acctgcagtt attcttcagc tgtttggaca acttagattg   4440

ggtttataac tattaggaat cactgcacag tttatttggg ttgtgttttg tgtctgagtc   4500

ccctccctca tcccttaggg tccagaagag caatggagga agtgacagct aatgttgcag   4560

ttcttattgt atggcatagg actggcatta tatagcagaa atcaactact gtacaatttc   4620

ttggggttaa ccatctttag ttaaatggaa ttttaattta aatgacgctt tgctaatttt   4680

aagtgttaag cattttgcat taaaatattc atataata                           4718


<210>  524
<211>  1321
<212>  PRT
<213>  Homosapiens

<400>  524

Met Val Leu Thr Leu Gly Glu Ser Trp Pro Val Leu Val Gly Arg Arg 
1               5                   10                  15      


Phe Leu Ser Leu Ser Ala Ala Asp Gly Ser Asp Gly Ser His Asp Ser 
            20                  25                  30          


Trp Asp Val Glu Arg Val Ala Glu Trp Pro Trp Leu Ser Gly Thr Ile 
        35                  40                  45              


Arg Ala Val Ser His Thr Asp Val Thr Lys Lys Asp Leu Lys Val Cys 
    50                  55                  60                  


Val Glu Phe Asp Gly Glu Ser Trp Arg Lys Arg Arg Trp Ile Glu Val 
65                  70                  75                  80  


Tyr Ser Leu Leu Arg Arg Ala Phe Leu Val Glu His Asn Leu Val Leu 
                85                  90                  95      


Ala Glu Arg Lys Ser Pro Glu Ile Ser Glu Arg Ile Val Gln Trp Pro 
            100                 105                 110         


Ala Ile Thr Tyr Lys Pro Leu Leu Asp Lys Ala Gly Leu Gly Ser Ile 
        115                 120                 125             


Thr Ser Val Arg Phe Leu Gly Asp Gln Gln Arg Val Phe Leu Ser Lys 
    130                 135                 140                 


Asp Leu Leu Lys Pro Ile Gln Asp Val Asn Ser Leu Arg Leu Ser Leu 
145                 150                 155                 160 


Thr Asp Asn Gln Ile Val Ser Lys Glu Phe Gln Ala Leu Ile Val Lys 
                165                 170                 175     


His Leu Asp Glu Ser His Leu Leu Lys Gly Asp Lys Asn Leu Val Gly 
            180                 185                 190         


Ser Glu Val Lys Ile Tyr Ser Leu Asp Pro Ser Thr Gln Trp Phe Ser 
        195                 200                 205             


Ala Thr Val Ile Asn Gly Asn Pro Ala Ser Lys Thr Leu Gln Val Asn 
    210                 215                 220                 


Cys Glu Glu Ile Pro Ala Leu Lys Ile Val Asp Pro Ser Leu Ile His 
225                 230                 235                 240 


Val Glu Val Val His Asp Asn Leu Val Thr Cys Gly Asn Ser Ala Arg 
                245                 250                 255     


Ile Gly Ala Val Lys Arg Lys Ser Ser Glu Asn Asn Gly Thr Leu Val 
            260                 265                 270         


Ser Lys Gln Ala Lys Ser Cys Ser Glu Ala Ser Pro Ser Met Cys Pro 
        275                 280                 285             


Val Gln Ser Val Pro Thr Thr Val Phe Lys Glu Ile Leu Leu Gly Cys 
    290                 295                 300                 


Thr Ala Ala Thr Pro Pro Ser Lys Asp Pro Arg Gln Gln Ser Thr Pro 
305                 310                 315                 320 


Gln Ala Ala Asn Ser Pro Pro Asn Leu Gly Ala Lys Ile Pro Gln Gly 
                325                 330                 335     


Cys His Lys Gln Ser Leu Pro Glu Glu Ile Ser Ser Cys Leu Asn Thr 
            340                 345                 350         


Lys Ser Glu Ala Leu Arg Thr Lys Pro Asp Val Cys Lys Ala Gly Leu 
        355                 360                 365             


Leu Ser Lys Ser Ser Gln Ile Gly Thr Gly Asp Leu Lys Ile Leu Thr 
    370                 375                 380                 


Glu Pro Lys Gly Ser Cys Thr Gln Pro Lys Thr Asn Thr Asp Gln Glu 
385                 390                 395                 400 


Asn Arg Leu Glu Ser Val Pro Gln Ala Leu Thr Gly Leu Pro Lys Glu 
                405                 410                 415     


Cys Leu Pro Thr Lys Ala Ser Ser Lys Ala Glu Leu Glu Ile Ala Asn 
            420                 425                 430         


Pro Pro Glu Leu Gln Lys His Leu Glu His Ala Pro Ser Pro Ser Asp 
        435                 440                 445             


Val Ser Asn Ala Pro Glu Val Lys Ala Gly Val Asn Ser Asp Ser Pro 
    450                 455                 460                 


Asn Asn Cys Ser Gly Lys Lys Val Glu Pro Ser Ala Leu Ala Cys Arg 
465                 470                 475                 480 


Ser Gln Asn Leu Lys Glu Ser Ser Val Lys Val Asp Asn Glu Ser Cys 
                485                 490                 495     


Cys Ser Arg Ser Asn Asn Lys Ile Gln Asn Ala Pro Ser Arg Lys Ser 
            500                 505                 510         


Val Leu Thr Asp Pro Ala Lys Leu Lys Lys Leu Gln Gln Ser Gly Glu 
        515                 520                 525             


Ala Phe Val Gln Asp Asp Ser Cys Val Asn Ile Val Ala Gln Leu Pro 
    530                 535                 540                 


Lys Cys Arg Glu Cys Arg Leu Asp Ser Leu Arg Lys Asp Lys Glu Gln 
545                 550                 555                 560 


Gln Lys Asp Ser Pro Val Phe Cys Arg Phe Phe His Phe Arg Arg Leu 
                565                 570                 575     


Gln Phe Asn Lys His Gly Val Leu Arg Val Glu Gly Phe Leu Thr Pro 
            580                 585                 590         


Asn Lys Tyr Asp Asn Glu Ala Ile Gly Leu Trp Leu Pro Leu Thr Lys 
        595                 600                 605             


Asn Val Val Gly Ile Asp Leu Asp Thr Ala Lys Tyr Ile Leu Ala Asn 
    610                 615                 620                 


Ile Gly Asp His Phe Cys Gln Met Val Ile Ser Glu Lys Glu Ala Met 
625                 630                 635                 640 


Ser Thr Ile Glu Pro His Arg Gln Val Ala Trp Lys Arg Ala Val Lys 
                645                 650                 655     


Gly Val Arg Glu Met Cys Asp Val Cys Asp Thr Thr Ile Phe Asn Leu 
            660                 665                 670         


His Trp Val Cys Pro Arg Cys Gly Phe Gly Val Cys Val Asp Cys Tyr 
        675                 680                 685             


Arg Met Lys Arg Lys Asn Cys Gln Gln Gly Ala Ala Tyr Lys Thr Phe 
    690                 695                 700                 


Ser Trp Leu Lys Cys Val Lys Ser Gln Ile His Glu Pro Glu Asn Leu 
705                 710                 715                 720 


Met Pro Thr Gln Ile Ile Pro Gly Lys Ala Leu Tyr Asp Val Gly Asp 
                725                 730                 735     


Ile Val His Ser Val Arg Ala Lys Trp Gly Ile Lys Ala Asn Cys Pro 
            740                 745                 750         


Cys Ser Asn Arg Gln Phe Lys Leu Phe Ser Lys Pro Ala Ser Lys Glu 
        755                 760                 765             


Asp Leu Lys Gln Thr Ser Leu Ala Gly Glu Lys Pro Thr Leu Gly Ala 
    770                 775                 780                 


Val Leu Gln Gln Asn Pro Ser Val Leu Glu Pro Ala Ala Val Gly Gly 
785                 790                 795                 800 


Glu Ala Ala Ser Lys Pro Ala Gly Ser Met Lys Pro Ala Cys Pro Ala 
                805                 810                 815     


Ser Thr Ser Pro Leu Asn Trp Leu Ala Asp Leu Thr Ser Gly Asn Val 
            820                 825                 830         


Asn Lys Glu Asn Lys Glu Lys Gln Pro Thr Met Pro Ile Leu Lys Asn 
        835                 840                 845             


Glu Ile Lys Cys Leu Pro Pro Leu Pro Pro Leu Ser Lys Ser Ser Thr 
    850                 855                 860                 


Val Leu His Thr Phe Asn Ser Thr Ile Leu Thr Pro Val Ser Asn Asn 
865                 870                 875                 880 


Asn Ser Gly Phe Leu Arg Asn Leu Leu Asn Ser Ser Thr Gly Lys Thr 
                885                 890                 895     


Glu Asn Gly Leu Lys Asn Thr Pro Lys Ile Leu Asp Asp Ile Phe Ala 
            900                 905                 910         


Ser Leu Val Gln Asn Lys Thr Thr Ser Asp Leu Ser Lys Arg Pro Gln 
        915                 920                 925             


Gly Leu Thr Ile Lys Pro Ser Ile Leu Gly Phe Asp Thr Pro His Tyr 
    930                 935                 940                 


Trp Leu Cys Asp Asn Arg Leu Leu Cys Leu Gln Asp Pro Asn Asn Lys 
945                 950                 955                 960 


Ser Asn Trp Asn Val Phe Arg Glu Cys Trp Lys Gln Gly Gln Pro Val 
                965                 970                 975     


Met Val Ser Gly Val His His Lys Leu Asn Ser Glu Leu Trp Lys Pro 
            980                 985                 990         


Glu Ser Phe Arg Lys Glu Phe Gly  Glu Gln Glu Val Asp  Leu Val Asn 
        995                 1000                 1005             


Cys Arg  Thr Asn Glu Ile Ile  Thr Gly Ala Thr Val  Gly Asp Phe 
    1010                 1015                 1020             


Trp Asp  Gly Phe Glu Asp Val  Pro Asn Arg Leu Lys  Asn Glu Lys 
    1025                 1030                 1035             


Glu Pro  Met Val Leu Lys Leu  Lys Asp Trp Pro Pro  Gly Glu Asp 
    1040                 1045                 1050             


Phe Arg  Asp Met Met Pro Ser  Arg Phe Asp Asp Leu  Met Ala Asn 
    1055                 1060                 1065             


Ile Pro  Leu Pro Glu Tyr Thr  Arg Arg Asp Gly Lys  Leu Asn Leu 
    1070                 1075                 1080             


Ala Ser  Arg Leu Pro Asn Tyr  Phe Val Arg Pro Asp  Leu Gly Pro 
    1085                 1090                 1095             


Lys Met  Tyr Asn Ala Tyr Gly  Leu Ile Thr Pro Glu  Asp Arg Lys 
    1100                 1105                 1110             


Tyr Gly  Thr Thr Asn Leu His  Leu Asp Val Ser Asp  Ala Ala Asn 
    1115                 1120                 1125             


Val Met  Val Tyr Val Gly Ile  Pro Lys Gly Gln Cys  Glu Gln Glu 
    1130                 1135                 1140             


Glu Glu  Val Leu Lys Thr Ile  Gln Asp Gly Asp Ser  Asp Glu Leu 
    1145                 1150                 1155             


Thr Ile  Lys Arg Phe Ile Glu  Gly Lys Glu Lys Pro  Gly Ala Leu 
    1160                 1165                 1170             


Trp His  Ile Tyr Ala Ala Lys  Asp Thr Glu Lys Ile  Arg Glu Phe 
    1175                 1180                 1185             


Leu Lys  Lys Val Ser Glu Glu  Gln Gly Gln Glu Asn  Pro Ala Asp 
    1190                 1195                 1200             


His Asp  Pro Ile His Asp Gln  Ser Trp Tyr Leu Asp  Arg Ser Leu 
    1205                 1210                 1215             


Arg Lys  Arg Leu His Gln Glu  Tyr Gly Val Gln Gly  Trp Ala Ile 
    1220                 1225                 1230             


Val Gln  Phe Leu Gly Asp Val  Val Phe Ile Pro Ala  Gly Ala Pro 
    1235                 1240                 1245             


His Gln  Val His Asn Leu Tyr  Ser Cys Ile Lys Val  Ala Glu Asp 
    1250                 1255                 1260             


Phe Val  Ser Pro Glu His Val  Lys His Cys Phe Trp  Leu Thr Gln 
    1265                 1270                 1275             


Glu Phe  Arg Tyr Leu Ser Gln  Thr His Thr Asn His  Glu Asp Lys 
    1280                 1285                 1290             


Leu Gln  Val Lys Asn Val Ile  Tyr His Ala Val Lys  Asp Ala Val 
    1295                 1300                 1305             


Ala Met  Leu Lys Ala Ser Glu  Ser Ser Phe Gly Lys  Pro 
    1310                 1315                 1320     


<210>  525
<211>  3113
<212>  DNA
<213>  Homosapiens

<400>  525
tgccgccgct ccctactctg ggggttggga ctacctcctt ttccgcgggc cccgcccagg     60

cggctgcccg tgacctgcct gggcgcgggg aactgaaagc cggaaggggc aagacgggtt    120

cagttcgtca tggggctgtt tggaaagacc caggagaagc cgcccaaaga actgatatcc    180

aaagagaaga agaaaaagtg aaacgatctg tgaaagatgc tgccaagaag ggccagaagg    240

atgtctgcat agttctggcc aaggagatga tcaggtcaag gaaggctgtg agcaagctgt    300

atgcatccaa agcacacatg aactcagtgc tcatggggat gaagaaccag ctcgcggtct    360

tgcgagtggc tggttccctg cagaagagca cagaagtgat gaaggccatg caaagtcttg    420

tgaagattcc agagattcag gccaccatga gggagttgtc caaagaaatg atgaaggctg    480

ggatcataga ggagatgtta gaggacactt ttgaaagcat ggacgatcag gaagaaatgg    540

aggaagaagc agaaatggaa attgacagaa ttctctttga aattacagca ggggccttgg    600

gcaaagcacc cagtaaagtg actgatgccc ttccagagcc agaacctcca ggagcgatgg    660

ctgcctcaga ggatgaggag gaggaggaag aggctctgga ggccatgcag tcccggctgg    720

ccacactccg cagctagggg ctgcctaccc cgctgggtgt gcacacactc ctctcaagag    780

ctgccatttt atgtgtctct tgcactacac ctctgttgtg aggactacca ttttggagaa    840

ggttctgttt gtctcttttc attctctgcc caggttttgg gatcgcaaag ggattgttct    900

tataaaagtg gcataaataa atgcatcatt tttaggagta tagacagata tatcttattg    960

tggggagggg aaagaaatcc atctgctcat gaagcacttc tgaaaatata ggtgattgcc   1020

tgaatgtcga agactctact tttgtctata aaacactata taaatgaatt ttaataaatt   1080

tttgctttag cacttggccc cattgtagat tgccctgtgc agtaaacttt caaggtgtcg   1140

gctgccccag attgcttcat ttgctgggtg tggaaagagt tgctatggcc aggcatatgg   1200

gatttggaag ctcagcagaa gtgacttctg ctctgtggtt gctgctcccc ggctttcaca   1260

gacatggtat ggcagccatt cttttatcta tttaaccaag aggatgctgg ggaattgtgc   1320

tgcttgtcct gttggctggt ggctgcatta tgtcctgggg tgtgcatgtg ggtctattta   1380

gagcttctgt cccttccttc ccattgcaag ttgcacccag atgagacagc tgtagtacta   1440

ggtctctttc acctctcatt gcctgtccct gcttcgagct ggttgtcttg tgcgtgggac   1500

atgggccttc ctatctgtgt tttctcaaag tcaggagctg accaggagca cactaaggtg   1560

tggtcatgca tcataaccaa cattcactca tctgggacat tcttaagata catttataaa   1620

tcatttcagc agtagtactt tgtatgtgtt gagagtttac agagctcttt gacatacgcg   1680

atcttagtct ttacaaataa ggaaaacagc tcagtttggg aagtatcaga gatgggattc   1740

aaacccagat cctctggtcc aagttgtatg tgcactgaac taatcaggca ggaaaaaagc   1800

ccagccactg tctcacagat tgttttttgt atattgtagc aaaatcctga aacaatgggg   1860

tccttccagt ctcatcatac aaaatggcaa tcttggctgg gtgcggtggt tcatgcctat   1920

aatcccagtg ctttacaagg ctgaggcagg aggctctctt gagaatagga gttcaagacc   1980

agcctgggca acatagcaag atcctgtctc tccaaaaaaa aaaaaaaaaa aaaaaaaaaa   2040

tttcattttt gagtccagag gaccctccta ttactcttga tttcatcttc agagtgtagt   2100

taaaaaatta ttttaaataa ttattttttt aaatcagttg taggttcaca gcaaaagtgg   2160

acaaaaagaa atttctcata tatcccctgc cctcacacat gcatagcctc ccaccactat   2220

cagtatccca caccagagtg gtacatttgt tacaatcaat aaacctccat tgacacatca   2280

ttatcaccca aagtccatag tttacatgaa gattcactct ggtgttgtac attgtatggg   2340

cttagacaaa tgtatgatga tatctacaat tatagaatca tacagaatag tttcactgcc   2400

ctaaaacttc tctatgcttc acctgttcat ccctttcttc cctaatcccc tggcaaccac   2460

tttaaaaaaa aaattaggtt cagggggtac atgtgcaggt aaactcgtga caagggggtt   2520

tgttatacag attatttagt gacccaggta ctaagcctag tacccaatag ttacttttct   2580

ggtcctgtcc cttttcccac cctccaccct caggtaggcc ccagtatgtt attcctttgt   2640

gtccatgtta tttcactccc acttgtgaga acatggaata tttggtttcc tgttcctatg   2700

ttagtttgtt aaggataatg gcctccagcc ccatccatgt tcctgcaaag gacatgatct   2760

ttctttggca accacttttt actgtcgcca tagttcttcc ttttctagaa tgtcatattg   2820

gaatcatata gtatgtagcc ttttcagact ggcttctttc acttaataat atgcaattaa   2880

ggttcctcca tgtcatttca tggcttaata gtgcatttat ttttagcact gaataatact   2940

ccattgtcta gatgaatagt ttatccattc acctattgaa agacttcttg gtggtttcca   3000

agttttggca attatgaata aagctgttgt aaacatcttt gtgcaggttt ttctatgggc   3060

atgtttttaa ttcatttgaa taaataccaa gagcttcagt gctggatcat aaa          3113


<210>  526
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  526

Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser Lys Ala 
1               5                   10                  15      


His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala Val Leu 
            20                  25                  30          


Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys Ala Met 
        35                  40                  45              


Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg Glu Leu 
    50                  55                  60                  


Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu Glu Asp 
65                  70                  75                  80  


Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu Ala Glu 
                85                  90                  95      


Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala Leu Gly 
            100                 105                 110         


Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu Pro Pro 
        115                 120                 125             


Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu Ala Leu 
    130                 135                 140                 


Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
145                 150                 155     


<210>  527
<211>  3174
<212>  DNA
<213>  Homosapiens

<400>  527
tgccgccgct ccctactctg ggggttggga ctacctcctt ttccgcgggc cccgcccagg     60

cggctgcccg tgacctgcct gggcgcgggg aactgaaagc cggaaggggc aagacgggtt    120

cagttcgtca tggggctgtt tggaaagacc caggagaagc cgcccaaaga actggtcaat    180

gagtggtcat tgaagataag aaaggaaatg agagttgttg acaggcaaat aagggatatc    240

caaagagaag aagaaaaagt gaaacgatct gtgaaagatg ctgccaagaa gggccagaag    300

gatgtctgca tagttctggc caaggagatg atcaggtcaa ggaaggctgt gagcaagctg    360

tatgcatcca aagcacacat gaactcagtg ctcatgggga tgaagaacca gctcgcggtc    420

ttgcgagtgg ctggttccct gcagaagagc acagaagtga tgaaggccat gcaaagtctt    480

gtgaagattc cagagattca ggccaccatg agggagttgt ccaaagaaat gatgaaggct    540

gggatcatag aggagatgtt agaggacact tttgaaagca tggacgatca ggaagaaatg    600

gaggaagaag cagaaatgga aattgacaga attctctttg aaattacagc aggggccttg    660

ggcaaagcac ccagtaaagt gactgatgcc cttccagagc cagaacctcc aggagcgatg    720

gctgcctcag aggatgagga ggaggaggaa gaggctctgg aggccatgca gtcccggctg    780

gccacactcc gcagctaggg gctgcctacc ccgctgggtg tgcacacact cctctcaaga    840

gctgccattt tatgtgtctc ttgcactaca cctctgttgt gaggactacc attttggaga    900

aggttctgtt tgtctctttt cattctctgc ccaggttttg ggatcgcaaa gggattgttc    960

ttataaaagt ggcataaata aatgcatcat ttttaggagt atagacagat atatcttatt   1020

gtggggaggg gaaagaaatc catctgctca tgaagcactt ctgaaaatat aggtgattgc   1080

ctgaatgtcg aagactctac ttttgtctat aaaacactat ataaatgaat tttaataaat   1140

ttttgcttta gcacttggcc ccattgtaga ttgccctgtg cagtaaactt tcaaggtgtc   1200

ggctgcccca gattgcttca tttgctgggt gtggaaagag ttgctatggc caggcatatg   1260

ggatttggaa gctcagcaga agtgacttct gctctgtggt tgctgctccc cggctttcac   1320

agacatggta tggcagccat tcttttatct atttaaccaa gaggatgctg gggaattgtg   1380

ctgcttgtcc tgttggctgg tggctgcatt atgtcctggg gtgtgcatgt gggtctattt   1440

agagcttctg tcccttcctt cccattgcaa gttgcaccca gatgagacag ctgtagtact   1500

aggtctcttt cacctctcat tgcctgtccc tgcttcgagc tggttgtctt gtgcgtggga   1560

catgggcctt cctatctgtg ttttctcaaa gtcaggagct gaccaggagc acactaaggt   1620

gtggtcatgc atcataacca acattcactc atctgggaca ttcttaagat acatttataa   1680

atcatttcag cagtagtact ttgtatgtgt tgagagttta cagagctctt tgacatacgc   1740

gatcttagtc tttacaaata aggaaaacag ctcagtttgg gaagtatcag agatgggatt   1800

caaacccaga tcctctggtc caagttgtat gtgcactgaa ctaatcaggc aggaaaaaag   1860

cccagccact gtctcacaga ttgttttttg tatattgtag caaaatcctg aaacaatggg   1920

gtccttccag tctcatcata caaaatggca atcttggctg ggtgcggtgg ttcatgccta   1980

taatcccagt gctttacaag gctgaggcag gaggctctct tgagaatagg agttcaagac   2040

cagcctgggc aacatagcaa gatcctgtct ctccaaaaaa aaaaaaaaaa aaaaaaaaaa   2100

atttcatttt tgagtccaga ggaccctcct attactcttg atttcatctt cagagtgtag   2160

ttaaaaaatt attttaaata attatttttt taaatcagtt gtaggttcac agcaaaagtg   2220

gacaaaaaga aatttctcat atatcccctg ccctcacaca tgcatagcct cccaccacta   2280

tcagtatccc acaccagagt ggtacatttg ttacaatcaa taaacctcca ttgacacatc   2340

attatcaccc aaagtccata gtttacatga agattcactc tggtgttgta cattgtatgg   2400

gcttagacaa atgtatgatg atatctacaa ttatagaatc atacagaata gtttcactgc   2460

cctaaaactt ctctatgctt cacctgttca tccctttctt ccctaatccc ctggcaacca   2520

ctttaaaaaa aaaattaggt tcagggggta catgtgcagg taaactcgtg acaagggggt   2580

ttgttataca gattatttag tgacccaggt actaagccta gtacccaata gttacttttc   2640

tggtcctgtc ccttttccca ccctccaccc tcaggtaggc cccagtatgt tattcctttg   2700

tgtccatgtt atttcactcc cacttgtgag aacatggaat atttggtttc ctgttcctat   2760

gttagtttgt taaggataat ggcctccagc cccatccatg ttcctgcaaa ggacatgatc   2820

tttctttggc aaccactttt tactgtcgcc atagttcttc cttttctaga atgtcatatt   2880

ggaatcatat agtatgtagc cttttcagac tggcttcttt cacttaataa tatgcaatta   2940

aggttcctcc atgtcatttc atggcttaat agtgcattta tttttagcac tgaataatac   3000

tccattgtct agatgaatag tttatccatt cacctattga aagacttctt ggtggtttcc   3060

aagttttggc aattatgaat aaagctgttg taaacatctt tgtgcaggtt tttctatggg   3120

catgttttta attcatttga ataaatacca agagcttcag tgctggatca taaa         3174


<210>  528
<211>  222
<212>  PRT
<213>  Homosapiens

<400>  528

Met Gly Leu Phe Gly Lys Thr Gln Glu Lys Pro Pro Lys Glu Leu Val 
1               5                   10                  15      


Asn Glu Trp Ser Leu Lys Ile Arg Lys Glu Met Arg Val Val Asp Arg 
            20                  25                  30          


Gln Ile Arg Asp Ile Gln Arg Glu Glu Glu Lys Val Lys Arg Ser Val 
        35                  40                  45              


Lys Asp Ala Ala Lys Lys Gly Gln Lys Asp Val Cys Ile Val Leu Ala 
    50                  55                  60                  


Lys Glu Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser 
65                  70                  75                  80  


Lys Ala His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala 
                85                  90                  95      


Val Leu Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys 
            100                 105                 110         


Ala Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg 
        115                 120                 125             


Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu 
    130                 135                 140                 


Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu 
145                 150                 155                 160 


Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala 
                165                 170                 175     


Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu 
            180                 185                 190         


Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu 
        195                 200                 205             


Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
    210                 215                 220         


<210>  529
<211>  3493
<212>  DNA
<213>  Homosapiens

<400>  529
ggctccggcc gcggccgccg ctgatacacg gttgtggagg gtacggccgc ggtctccgga     60

ggtggcgggg gtgttgggga cgggtgctgc gaccggcact gcccatccga gcgggacggg    120

cgctgagtgg ccgggaggca gccgggtagc cgcctggagg agcagtctcg gggcctatta    180

ttggtttttt ccctccgaga ccgattccat ctgcagagac cgcgacgccc catcctgggc    240

cgggccgcag tgcccgcccg cctgagaggc gccgcccgcc agccggcccg agcgaacctg    300

gagccgccgc cgtgcccgcc gctcttctcg cggagcctgg gcggtcggcg gggcctgggg    360

cctgggcttc gggcgcggcg ttgcggcggc cgctcctccc cgcgcagaac acgctgggcc    420

ccgggcctgg cccggccgag cgccgcgccc tcctgacccg cggccgcggg agtccggccc    480

ccacggcccc tcgggccccg gcctgccgcc cggatccccg cctcctgggc ggatctgagt    540

tattttttgg tctccccctc ccccttgaga tcgcggcacc ggagggccga ccccgccacc    600

tgggtcagtg cccgccccgg gggaagcgtc cctcgttttg ttcttccccg cgagctctcc    660

ccgcgcccct ctcctttctg tgcttaatgg atgggggttt tgagtttttc ccctttattt    720

ttgtcggctc ttgactggga ggcccggcgc gaggctctgc gtctctgcgt ccctcgtcgc    780

cgcctcgcgc ccgcgcggat cccgtcacct gcttccccgc cggggatggc cggccagtga    840

cggcgccggg tggcccgcgc gtggacacgg ggccctcgcc caagctgcca ccgagccgcg    900

gcccccgccc tcgacccttc tctctcccgt attccgagct ctctggaaag agaggaaact    960

ccagggaaga tgtggctgaa gctttttttc ttgctcctct atttcctggt cctgttcgtc   1020

ctggccaggt tttttgaggc cattgtgtgg tatgaaactg gcatctttgc cacccagctg   1080

gtggatccgg tggcgctgag cttcaagaag ctgaagacca ttttggagtg ccgggggttg   1140

ggctactcag ggttgcccga gaagaaggat gtccgggagc tggtggaaaa gtcaggtgac   1200

ttgatggagg gtgagctcta ttctgctctc aaggaagaag aagcatccga atcggtttct   1260

agtaccaatt tcagtggtga aatgcacttc tatgagcttg tggaagacac aaaagatggc   1320

atctggctgg ttcaggtcat agcaaatgac agaagtccct tggtgggcaa aattcactgg   1380

gagaaaatgg ttaaaaaggt gtcaagattt ggaatacgta caggcacatt taactgttcc   1440

agtgatccca gatattgcag gagaagaggc tgggtccgat ccacactcat tatgtctgtt   1500

ccacaaacaa gtacttcaaa agggaaagtc atgcttaaag aatacagtgg acgcaagatt   1560

gaagtagagc acatttttaa atggataact gctcatgcag cttctcggat caaaaccatt   1620

tataatgctg aacacttgaa agaagaatgg aataaaagtg atcagtattg gttaaaaata   1680

tacctatttg caaaccttga ccagccccca gctttcttct ctgcactaag tataaagttt   1740

actggaagag ttgagtttat ttttgttaat gtagaaaatt gggacaacaa gagttatatg   1800

acagatattg gcatatataa tatgccatca tacatactta gaactcctga aggaatttac   1860

aggtatggaa accacacagg cgaatttata tcccttcagg ccatggattc atttttgcgc   1920

tcattacaac ccgaggtaaa tgatctgttt gttttgagct tggttctagt taatcttatg   1980

gcttggatgg acttatttat tacacaagga gctaccataa agcgatttgt ggttctcata   2040

agcactttag ggacatataa ttctctatta attatttcct ggctacctgt gttgggcttt   2100

ttacagctac cttacttaga tagcttttat gaatatagct taaaattgtt gagatattcc   2160

aatacaacca cactggcttc atgggtaagg gcagactgga tgttttactc ttcacaccca   2220

gccctgtttc tcagtacata ccttggtcat ggtttactaa ttgattactt tgagaagaag   2280

agaaggcgca acaacaacaa tgatgaagtc aatgccaata acttagaatg gttatcaagt   2340

ctgtgggact ggtacaccag ctacctcttc cacccgattg cttcttttca gaactttcct   2400

gtagaatctg attgggacga agaccctgac ttattcttgg agcgcttagc tttccctgac   2460

ctttggcttc accctctgat accaactgat tatattaaaa acttaccaat gtggcgattt   2520

aaatgtcttg gagtccagtc tgaagaggaa atgtcggagg ggtctcaaga tactgaaaat   2580

gactcggaaa gtgagaacac agacactttg agtagtgaga aggaagtatt tgaagataag   2640

caaagcgtac ttcacaattc tccaggaaca gcaagtcact gtgatgctga ggcttgttca   2700

tgtgccaata aatattgtca gaccagccca tgtgaaagga aggggaggtc atatggatca   2760

tataacacta atgaagatat ggaacctgat tggttaactt ggcctgctga tatgctgcac   2820

tgtactgaat gtgttgtttg cctagagaat tttgaaaatg gatgtttgct aatggggttg   2880

ccttgtggtc atgtgtttca tcagaattgc attgtgatgt ggttggctgg gggccgacat   2940

tgttgccctg tttgccggtg gccttcttat aaaaaaaagc agccatatgc acaacaccag   3000

cccttgtcaa atgatgtccc atcttaacca tgtgcaattt gtcctttata agctttgagt   3060

atcttacagc ttgccttttt aatgttagtc acaatgtttt tgtggtttga agtttagttt   3120

aatgttagtg cagtgacggg aaatacacat tatgctaatg ttgatgacag aatttatttg   3180

gttgccttgt gtgttaattg aatgcatacc taattgtaaa atttttttat ttacaacatt   3240

ggaaattcag aagttaatgt ttttttgtaa gcacaaaaga agtattatag aaatttatcc   3300

tagcaagact ttacaagata ggatcaaatt ctaatggaat tgagccggtt tcttatccta   3360

aatgtttcct ccctttttac aatctctgtc cagcacctct tggttaaata atgtatgctg   3420

tgagacatga aattaaaaca gacctatgaa ataaattatt ttaaaaccag aagattaaaa   3480

aaaaaaaaaa aaa                                                      3493


<210>  530
<211>  685
<212>  PRT
<213>  Homosapiens

<400>  530

Met Trp Leu Lys Leu Phe Phe Leu Leu Leu Tyr Phe Leu Val Leu Phe 
1               5                   10                  15      


Val Leu Ala Arg Phe Phe Glu Ala Ile Val Trp Tyr Glu Thr Gly Ile 
            20                  25                  30          


Phe Ala Thr Gln Leu Val Asp Pro Val Ala Leu Ser Phe Lys Lys Leu 
        35                  40                  45              


Lys Thr Ile Leu Glu Cys Arg Gly Leu Gly Tyr Ser Gly Leu Pro Glu 
    50                  55                  60                  


Lys Lys Asp Val Arg Glu Leu Val Glu Lys Ser Gly Asp Leu Met Glu 
65                  70                  75                  80  


Gly Glu Leu Tyr Ser Ala Leu Lys Glu Glu Glu Ala Ser Glu Ser Val 
                85                  90                  95      


Ser Ser Thr Asn Phe Ser Gly Glu Met His Phe Tyr Glu Leu Val Glu 
            100                 105                 110         


Asp Thr Lys Asp Gly Ile Trp Leu Val Gln Val Ile Ala Asn Asp Arg 
        115                 120                 125             


Ser Pro Leu Val Gly Lys Ile His Trp Glu Lys Met Val Lys Lys Val 
    130                 135                 140                 


Ser Arg Phe Gly Ile Arg Thr Gly Thr Phe Asn Cys Ser Ser Asp Pro 
145                 150                 155                 160 


Arg Tyr Cys Arg Arg Arg Gly Trp Val Arg Ser Thr Leu Ile Met Ser 
                165                 170                 175     


Val Pro Gln Thr Ser Thr Ser Lys Gly Lys Val Met Leu Lys Glu Tyr 
            180                 185                 190         


Ser Gly Arg Lys Ile Glu Val Glu His Ile Phe Lys Trp Ile Thr Ala 
        195                 200                 205             


His Ala Ala Ser Arg Ile Lys Thr Ile Tyr Asn Ala Glu His Leu Lys 
    210                 215                 220                 


Glu Glu Trp Asn Lys Ser Asp Gln Tyr Trp Leu Lys Ile Tyr Leu Phe 
225                 230                 235                 240 


Ala Asn Leu Asp Gln Pro Pro Ala Phe Phe Ser Ala Leu Ser Ile Lys 
                245                 250                 255     


Phe Thr Gly Arg Val Glu Phe Ile Phe Val Asn Val Glu Asn Trp Asp 
            260                 265                 270         


Asn Lys Ser Tyr Met Thr Asp Ile Gly Ile Tyr Asn Met Pro Ser Tyr 
        275                 280                 285             


Ile Leu Arg Thr Pro Glu Gly Ile Tyr Arg Tyr Gly Asn His Thr Gly 
    290                 295                 300                 


Glu Phe Ile Ser Leu Gln Ala Met Asp Ser Phe Leu Arg Ser Leu Gln 
305                 310                 315                 320 


Pro Glu Val Asn Asp Leu Phe Val Leu Ser Leu Val Leu Val Asn Leu 
                325                 330                 335     


Met Ala Trp Met Asp Leu Phe Ile Thr Gln Gly Ala Thr Ile Lys Arg 
            340                 345                 350         


Phe Val Val Leu Ile Ser Thr Leu Gly Thr Tyr Asn Ser Leu Leu Ile 
        355                 360                 365             


Ile Ser Trp Leu Pro Val Leu Gly Phe Leu Gln Leu Pro Tyr Leu Asp 
    370                 375                 380                 


Ser Phe Tyr Glu Tyr Ser Leu Lys Leu Leu Arg Tyr Ser Asn Thr Thr 
385                 390                 395                 400 


Thr Leu Ala Ser Trp Val Arg Ala Asp Trp Met Phe Tyr Ser Ser His 
                405                 410                 415     


Pro Ala Leu Phe Leu Ser Thr Tyr Leu Gly His Gly Leu Leu Ile Asp 
            420                 425                 430         


Tyr Phe Glu Lys Lys Arg Arg Arg Asn Asn Asn Asn Asp Glu Val Asn 
        435                 440                 445             


Ala Asn Asn Leu Glu Trp Leu Ser Ser Leu Trp Asp Trp Tyr Thr Ser 
    450                 455                 460                 


Tyr Leu Phe His Pro Ile Ala Ser Phe Gln Asn Phe Pro Val Glu Ser 
465                 470                 475                 480 


Asp Trp Asp Glu Asp Pro Asp Leu Phe Leu Glu Arg Leu Ala Phe Pro 
                485                 490                 495     


Asp Leu Trp Leu His Pro Leu Ile Pro Thr Asp Tyr Ile Lys Asn Leu 
            500                 505                 510         


Pro Met Trp Arg Phe Lys Cys Leu Gly Val Gln Ser Glu Glu Glu Met 
        515                 520                 525             


Ser Glu Gly Ser Gln Asp Thr Glu Asn Asp Ser Glu Ser Glu Asn Thr 
    530                 535                 540                 


Asp Thr Leu Ser Ser Glu Lys Glu Val Phe Glu Asp Lys Gln Ser Val 
545                 550                 555                 560 


Leu His Asn Ser Pro Gly Thr Ala Ser His Cys Asp Ala Glu Ala Cys 
                565                 570                 575     


Ser Cys Ala Asn Lys Tyr Cys Gln Thr Ser Pro Cys Glu Arg Lys Gly 
            580                 585                 590         


Arg Ser Tyr Gly Ser Tyr Asn Thr Asn Glu Asp Met Glu Pro Asp Trp 
        595                 600                 605             


Leu Thr Trp Pro Ala Asp Met Leu His Cys Thr Glu Cys Val Val Cys 
    610                 615                 620                 


Leu Glu Asn Phe Glu Asn Gly Cys Leu Leu Met Gly Leu Pro Cys Gly 
625                 630                 635                 640 


His Val Phe His Gln Asn Cys Ile Val Met Trp Leu Ala Gly Gly Arg 
                645                 650                 655     


His Cys Cys Pro Val Cys Arg Trp Pro Ser Tyr Lys Lys Lys Gln Pro 
            660                 665                 670         


Tyr Ala Gln His Gln Pro Leu Ser Asn Asp Val Pro Ser 
        675                 680                 685 


<210>  531
<211>  3239
<212>  DNA
<213>  Homosapiens

<400>  531
gcttggggaa cgaggagcag gacgcggcct cggtggggcc cgggccgaac ggctgcggac     60

acctgggcgc cgaggagccg agcgccgccg tctccggcat ggatcagtgc gtgacggtgg    120

agcgcgagct ggagaaggtg ctgcacaagt tctcaggcta cgggcagctg tgcgagcgcg    180

gcctggagga gctcatcgac tacaccggcg gcctcaagca cgagatcctg cagagccacg    240

gccaagatgc tgaattatca gggacacttt cacttgtttt gacacagtgc tgtaaaagaa    300

taaaggatac tgttcaaaaa ttggcctccg accacaaaga catccacagc agtgtttctc    360

gggttggaaa agccattgat aagaattttg attctgacat tagcagtgtg ggaatagatg    420

gctgctggca ggcagacagc caaaggcttc tcaatgaagt gatggtggag cacttctttc    480

gacaaggaat gctggatgtg gctgaggagc tctgtcagga atctggtctt tctgtagacc    540

caagtcagaa ggaaccattt gtggagttaa atagaatatt agaggcatta aaggtcagag    600

ttctgagacc tgctctggag tgggcagtgt caaaccggga aatgcttata gctcaaaaca    660

gctccttgga atttaagcta cacagactgt attttattag cttgttaatg ggtggaacca    720

caaatcagcg agaggcatta caatatgcta aaaattttca gccatttgcc ctaaatcatc    780

aaaaagacat tcaggttttg atgggaagcc ttgtgtacct gagacaaggg attgagaact    840

caccatatgt tcacctactt gatgcaaacc agtgggctga tatctgtgac atctttacac    900

gggatgcttg tgccctcctg gggctctccg tggagtcccc tctcagtgtc agtttctcag    960

caggttgtgt ggcgctgcca gctttaatta acatcaaagc cgtgattgaa cagaggcagt   1020

gtactggagt ttggaaccag aaagatgaat tacctattga agtggacctt ggtaaaaagt   1080

gctggtatca ctctatattt gcctgcccca ttcttcgtca gcaaacaaca gataacaatc   1140

cacccatgaa attggtctgt ggtcatatta tatcaagaga tgccctgaat aaaatgttta   1200

atggtagcaa attaaaatgt ccctactgtc caatggaaca aagtccagga gatgccaaac   1260

agatattttt ctgaagagat aactttagtt tgcaatttgt aagtgaaact gaatcgtggg   1320

tgcatttcag aagagaacgt tccatataat gcagctaacc aaggactcct gtgtttctat   1380

aagctaatgc tccagaaact ttgccaacct gttagtgtac acacactgag gggagtgctc   1440

ccggtgaata ttatcatagg gctttattat attcttggtc ttcatttctg atcaagtaaa   1500

tacaccagca gttgtcattc aatgcaggtt tttgtactta attatatggt gattttttta   1560

ctttttaaga gcagaaacgg aaattgacct ccccgccatg tgtttaatat tcctcctgct   1620

tttacttttg tcattttctt gataatcgta agccttgaga gtgtttgtga aaaagtttta   1680

tttcctgtta tgtatacata attaaatgaa aattcttcag aaaaagtttg ataaattgaa   1740

ttgtggttat gaaactaatt tgcattttta tttgcttaag aaagaaagct gtgatagatt   1800

ccagatatgc tttttgatgt tttcctctgc tccagctcca agaagtcagc acacctgcat   1860

tttagctctg catgcagccc cagcaggctg cgtgtttaag aatttcattg tttaactggc   1920

tggtgtgaga agtcttccgt tagcatagag tggaaggagt actattgttt ggttgggttt   1980

ttgtttgttt gttttttgtt tttgctttta ttgccaagag gtgcttgttt taaaagtatg   2040

tttaataaaa tgaaattcta aagttagaag tgttcttaag ttgatattta ctctcttggt   2100

cttggtagcc ctattatatc attgcagaca cagtgttgtg catgtgtgta ttgtatatgt   2160

gcaccagcat caaacattgt gtatctggaa ggaaagcagc atgttccagt tctaaaatgc   2220

agttaccaga cccatcactt taaatcctta aagttagaag ctagcaaatt ttctgtagtg   2280

cagaacgttt attgctgttt ttgtgtttga atagtataat gtttgatgcc tctcttctgc   2340

aaagcgtatc atctcattga ctgtgaatct gtatattatt ctgatggata cagataatga   2400

tcttttctct tgtgaggtat cttcatttat gcactgtcca aaaatagcca tgtgtaagag   2460

tctttctgta tgacgaacta catggaaaag acttctgtgg acataattct gaccgaaacc   2520

catgaagtta cttcagtata agaagaacgt tacacggaaa tcaccaaata ttttgcaact   2580

ttatttcttc tgacatggag tgaacatcaa taggaatact ttcaaagaaa atgaaaacac   2640

agaagcaaag agaaatgtgg cacttcacat tttaaactac agatggactt ggtttgaggg   2700

agggggaatc acagatttgg tgctaagtta attagaaact ggcagcgttt tacagtagta   2760

caccagcctg gatgtttttt ctaaaatgtt tacctgggag agctggggtt tgtttgtgag   2820

gagaaagagt actgtggaaa acctctgctt gagtaccatg tggccaggcc tatgtggatg   2880

gctactccgt gctgtgcggc ttcaccagcg gttgggattg gcccagcttg gagtgcttgt   2940

gtggtccaac ctcagtctgg ccccatagtg acttttgccc catgattctg cttcactgtt   3000

ggaatcctct ttgaagttcc ccctctcttt gctaaagcag tgaaggaaga gaacagagac   3060

aaactctttg gactgtgaaa gagaaggtag agaattccag gcaacagtct gaccaagggt   3120

gtaaaccagt ttattatata tatatttttc ctttgaatta aaacctatga gtgactacaa   3180

aaaggattag actgagccga ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa    3239


<210>  532
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  532

Met Asp Gln Cys Val Thr Val Glu Arg Glu Leu Glu Lys Val Leu His 
1               5                   10                  15      


Lys Phe Ser Gly Tyr Gly Gln Leu Cys Glu Arg Gly Leu Glu Glu Leu 
            20                  25                  30          


Ile Asp Tyr Thr Gly Gly Leu Lys His Glu Ile Leu Gln Ser His Gly 
        35                  40                  45              


Gln Asp Ala Glu Leu Ser Gly Thr Leu Ser Leu Val Leu Thr Gln Cys 
    50                  55                  60                  


Cys Lys Arg Ile Lys Asp Thr Val Gln Lys Leu Ala Ser Asp His Lys 
65                  70                  75                  80  


Asp Ile His Ser Ser Val Ser Arg Val Gly Lys Ala Ile Asp Lys Asn 
                85                  90                  95      


Phe Asp Ser Asp Ile Ser Ser Val Gly Ile Asp Gly Cys Trp Gln Ala 
            100                 105                 110         


Asp Ser Gln Arg Leu Leu Asn Glu Val Met Val Glu His Phe Phe Arg 
        115                 120                 125             


Gln Gly Met Leu Asp Val Ala Glu Glu Leu Cys Gln Glu Ser Gly Leu 
    130                 135                 140                 


Ser Val Asp Pro Ser Gln Lys Glu Pro Phe Val Glu Leu Asn Arg Ile 
145                 150                 155                 160 


Leu Glu Ala Leu Lys Val Arg Val Leu Arg Pro Ala Leu Glu Trp Ala 
                165                 170                 175     


Val Ser Asn Arg Glu Met Leu Ile Ala Gln Asn Ser Ser Leu Glu Phe 
            180                 185                 190         


Lys Leu His Arg Leu Tyr Phe Ile Ser Leu Leu Met Gly Gly Thr Thr 
        195                 200                 205             


Asn Gln Arg Glu Ala Leu Gln Tyr Ala Lys Asn Phe Gln Pro Phe Ala 
    210                 215                 220                 


Leu Asn His Gln Lys Asp Ile Gln Val Leu Met Gly Ser Leu Val Tyr 
225                 230                 235                 240 


Leu Arg Gln Gly Ile Glu Asn Ser Pro Tyr Val His Leu Leu Asp Ala 
                245                 250                 255     


Asn Gln Trp Ala Asp Ile Cys Asp Ile Phe Thr Arg Asp Ala Cys Ala 
            260                 265                 270         


Leu Leu Gly Leu Ser Val Glu Ser Pro Leu Ser Val Ser Phe Ser Ala 
        275                 280                 285             


Gly Cys Val Ala Leu Pro Ala Leu Ile Asn Ile Lys Ala Val Ile Glu 
    290                 295                 300                 


Gln Arg Gln Cys Thr Gly Val Trp Asn Gln Lys Asp Glu Leu Pro Ile 
305                 310                 315                 320 


Glu Val Asp Leu Gly Lys Lys Cys Trp Tyr His Ser Ile Phe Ala Cys 
                325                 330                 335     


Pro Ile Leu Arg Gln Gln Thr Thr Asp Asn Asn Pro Pro Met Lys Leu 
            340                 345                 350         


Val Cys Gly His Ile Ile Ser Arg Asp Ala Leu Asn Lys Met Phe Asn 
        355                 360                 365             


Gly Ser Lys Leu Lys Cys Pro Tyr Cys Pro Met Glu Gln Ser Pro Gly 
    370                 375                 380                 


Asp Ala Lys Gln Ile Phe Phe 
385                 390     


<210>  533
<211>  4814
<212>  DNA
<213>  Homosapiens

<400>  533
agttggctcg gcggcagcgg agcggccgga gctgcggtgc ggaccggggc cgcgcggcgt     60

ggcgcgggga gcggcggcgg cggcagagcc agagcaacat ggcgccggtg ggcgggggcg    120

ggcgcccggt cggcggaccg gcccgcgggc gcctcctcct ggcggcgccg gtgctgctgg    180

tgctgctgtg ggcgctgggg gcccggggcc agggcagccc ccagcagggc acgatcgtgg    240

gcatgaggct ggcgagctgc aacaagtcgt gtgggacgaa cccggatggc atcatcttcg    300

tgtccgaggg cagcaccgtg aacctgaggc tgtacggcta cagcctgggc aacatctcca    360

gcaacctgat ctccttcacc gaggtggacg atgccgagac cctccacaag tccaccagct    420

gcctcgagct caccaaggac ctggtcgtcc agcagctggt caacgtgagc cgcgggaaca    480

cgtccggcgt gctggtggtg ctcaccaagt tcctccggag gagcgagagc atgaagctgt    540

atgcactgtg cacccgggcc cagcccgacg ggccctggct gaagtggacg gacaaggact    600

cactgctctt catggtggag gagcctggga ggttcctgcc tctctggctg cacattctcc    660

taattacggt gctgctggtg ctgtcgggca tattttctgg cctcaacctc gggcttatgg    720

ccctggaccc catggagctg cgcatcgtgc agaactgtgg caccgagaag gagaggcgct    780

atgcccgcaa gattgagccc atccggcgca agggcaacta ccttctctgc tcgttgctcc    840

tagggaacgt gctggtcaac acctccctca caatccttct agacaacctc atcgggtccg    900

gcctcatggc ggtggcctcc tccaccattg gcattgtcat ctttggggag atcctacctc    960

aggccctgtg ctcccgacat gggctggctg tgggtgccaa caccatcctt ctcaccaaat   1020

tctttatgct actcaccttc cccctcagtt ttcccattag caagctcctg gacttttttc   1080

tgggccagga gattcgcact gtttacaacc gggagaagct gatggagatg ttgaaggtga   1140

cggagcccta taatgacctc gtgaaagagg agctcaatat gatccagggt gccctggaac   1200

tacggaccaa aactgtagag gatatcatga cccagctcca ggactgcttc atgatccgca   1260

gcgatgccat cctggacttc aacaccatgt cggagataat ggaaagcggc tatactcgca   1320

tcccggtgtt cgaagacgag cagtccaata ttgtagatat tctctacgtc aaagacttgg   1380

cctttgtgga ccccgatgac tgcacccccc tcaagactat cactcgcttc tataaccacc   1440

cggtgcactt tgtcttccat gacaccaagt tggatgccat gctggaggag ttcaagaagg   1500

ggaagtccca cctggccatc gtgcagaagg taaacaacga gggtgagggt gaccccttct   1560

acgaggtcct gggcctggtc accctggagg acgtgatcga ggagatcatc aagtcggaga   1620

tcctggacga gtccgacatg tacactgaca accgaagccg gaagcgggtg tctgagaaga   1680

acaagcgtga cttctctgcc ttcaaggatg cggacaatga gctcaaagtg aaaatctccc   1740

cgcagctcct cctggccgct catcgcttcc tagccacaga ggtctctcag tttagcccct   1800

ccctgatatc agagaagatc ctgctgcggc tactcaagta cccagatgtc attcaggaac   1860

tcaagtttga cgagcacaat aagtactacg cccgccatta cctgtacacc cgaaataagc   1920

cggccgacta cttcatcctc atcctgcagg ggaaggtgga ggtggaggca gggaaggaga   1980

acatgaagtt tgagacgggc gccttctcct actatgggac tatggccctg acctcggtcc   2040

cctccgaccg ttccccagca caccccaccc cactcagccg ctcagcctcc ctcagttacc   2100

cagaccgcac agacgtctca actgcagcaa ccttggcagg cagcagcaac cagtttggca   2160

gctctgtcct gggccagtac atctctgact tcagcgtccg ggcactcgtg gacttgcagt   2220

acatcaagat cactcggcag cagtaccaga acgggctgct ggcttctcgc atggagaaca   2280

gccctcagtt tcccatagac gggtgcacca cccacatgga gaacttggcc gagaagtctg   2340

agctgcctgt ggtggacgag accacaactc ttctcaacga gcgtaactcc ttgctgcaca   2400

aagcctccca cgagaatgcc atctgacagg agggcccggg gccccctgcc caccctgcgg   2460

gggcctcccc agtgggccca catgaagaga gggaacctgt tagtccagaa aggatacgga   2520

tagatagcct gtctgactga acagccagat ggcccccagc ctatggggga tctggcctct   2580

gccagggacc tctgagtagc tctgaggtgg cactgtccag ccctggatag ggggggcagt   2640

gggccagcta ccgtaagcaa aggctgtttt ttactgagag aatttctaaa gtaggctcat   2700

cacttttttt taaatatcat tttgggaagg gaagacaggg ttaaggaact ttatttaaaa   2760

aaaaaatatt tttttcctaa aaactataaa agaggaaggg tttcttgtcc cgggaagcaa   2820

cggacataat ctgttcccag ccatggcctt ccagcttgtg tccctgattc agggagctct   2880

cccttcctcc tcctcctcct cctccggagg tgggatccca gagcctgcca gtggaggctt   2940

atctgttggg aggaagacag ctcttcacag aagcaaagaa caaaatggca tggagatcag   3000

ctgcctgagc acctgcgctg tagcttatct gacaacgctg aggccacgag ctcctgggta   3060

gctgtgatca gggacatgat aatctgagct atgcagagga gcacatctgt tgtcaactgc   3120

tgtacccaga aatctagaac tctgccgaca gcctctcctg gtgagtcggg actcagctga   3180

ggacacatcc ccaccctgcc tcccatctgg ccctttggac aactggccct ttgtgacagg   3240

gctgactcaa gtgttaggca gggtctcagg cctttgattg ctcacccctg ctccccaggc   3300

cctgccctca cttttaccaa aggttctccc tcggcgggag ggcatctgtg ttggaggtga   3360

tttgtctggg ttcttccttt tggttccaga aggaactgtc agtcatcagc atctgcgttg   3420

ttagcagtca gtaccacccc cgccccacaa tgacagtcaa ggctgacttg ttgactgaag   3480

cctttttccc agacccctta tttcgaatcc ccaagcttca gtccctcttg ggggtggaga   3540

caagaggaca tgtgggaagc cacggaagca ggttctttat gtcctctcct ctgtggctgg   3600

caaggctcac ctggccttat ccacccactt atggaacctc aggagaggag ggctcctcct   3660

aaaggcatgc agcttgcagc ccctctttct cacacgtgtg atcctagcgt gagaggtcat   3720

cctgcccttg ctgaagttag tagtactgta ctaagagctc tgccctcatg tgaattcctg   3780

ccctggcgcc tcttccctgg ggctgaatca ggccctgctg caaaactcca ggcttcccag   3840

ggttggggag gctgtgggac caaggtccat gttggtcctt ccactgggtg cagcaggagc   3900

tgggtcccga gagcctggca ggtgaaactc tgcaggcctt ccgcctgatt attatttatt   3960

cactcctttc ctcaccccaa gtgccctgct ctccaggtgc ctagagtatc ctaactctta   4020

ggaccaggga ttgtcttgca ccaagtatgc ctacccctgg ccagtctgag gtctcctagc   4080

catagaactg actcctggaa gcctggagag aaggtggtga cacccatggg ttctcaactg   4140

taaggaaaaa agacaccaga cttttgttcc ctagtggggg aaagccctta gtcttgtaca   4200

ggagcagctt gctcccaagt ccttttggaa gctggcagag ctatattcct gacagccctg   4260

actgccaggt agagcaaaag acattggtgg gggtatgtga agcaaaaggg gcaggtgcac   4320

acacctccac agtgacctct gtgcacacgg ttaccaccaa ctggctggcc ctcctcctct   4380

tccctggccc attgatcatc ccttctcaca gagggtcatc attatttcca aatattgttt   4440

gtctgatgac ttcctcttcc cagtgcaatt tttcccttcc tatttcaacc tctggttcct   4500

gggatgagcc ataccctgga actggcccac ccactgtgtc ttccacgtaa gggagacctt   4560

tgcaaagggc atccaaatgg gtaggcaggt gacagccgcc gtatttattt tgcataatat   4620

tttaatttgt atatttttgt gatttatttt ggcgttatga gtttgactct cggggagttt   4680

tgttgttatg actcttgtgt cttttgtcac aaaacaatga tatttgctaa acgatatatg   4740

gaatttattt ttgattggta ataaaaaatc aaatatgtat aaatcctggt gaatctacaa   4800

aaaaaaaaaa aaaa                                                     4814


<210>  534
<211>  775
<212>  PRT
<213>  Homosapiens

<400>  534

Met Ala Pro Val Gly Gly Gly Gly Arg Pro Val Gly Gly Pro Ala Arg 
1               5                   10                  15      


Gly Arg Leu Leu Leu Ala Ala Pro Val Leu Leu Val Leu Leu Trp Ala 
            20                  25                  30          


Leu Gly Ala Arg Gly Gln Gly Ser Pro Gln Gln Gly Thr Ile Val Gly 
        35                  40                  45              


Met Arg Leu Ala Ser Cys Asn Lys Ser Cys Gly Thr Asn Pro Asp Gly 
    50                  55                  60                  


Ile Ile Phe Val Ser Glu Gly Ser Thr Val Asn Leu Arg Leu Tyr Gly 
65                  70                  75                  80  


Tyr Ser Leu Gly Asn Ile Ser Ser Asn Leu Ile Ser Phe Thr Glu Val 
                85                  90                  95      


Asp Asp Ala Glu Thr Leu His Lys Ser Thr Ser Cys Leu Glu Leu Thr 
            100                 105                 110         


Lys Asp Leu Val Val Gln Gln Leu Val Asn Val Ser Arg Gly Asn Thr 
        115                 120                 125             


Ser Gly Val Leu Val Val Leu Thr Lys Phe Leu Arg Arg Ser Glu Ser 
    130                 135                 140                 


Met Lys Leu Tyr Ala Leu Cys Thr Arg Ala Gln Pro Asp Gly Pro Trp 
145                 150                 155                 160 


Leu Lys Trp Thr Asp Lys Asp Ser Leu Leu Phe Met Val Glu Glu Pro 
                165                 170                 175     


Gly Arg Phe Leu Pro Leu Trp Leu His Ile Leu Leu Ile Thr Val Leu 
            180                 185                 190         


Leu Val Leu Ser Gly Ile Phe Ser Gly Leu Asn Leu Gly Leu Met Ala 
        195                 200                 205             


Leu Asp Pro Met Glu Leu Arg Ile Val Gln Asn Cys Gly Thr Glu Lys 
    210                 215                 220                 


Glu Arg Arg Tyr Ala Arg Lys Ile Glu Pro Ile Arg Arg Lys Gly Asn 
225                 230                 235                 240 


Tyr Leu Leu Cys Ser Leu Leu Leu Gly Asn Val Leu Val Asn Thr Ser 
                245                 250                 255     


Leu Thr Ile Leu Leu Asp Asn Leu Ile Gly Ser Gly Leu Met Ala Val 
            260                 265                 270         


Ala Ser Ser Thr Ile Gly Ile Val Ile Phe Gly Glu Ile Leu Pro Gln 
        275                 280                 285             


Ala Leu Cys Ser Arg His Gly Leu Ala Val Gly Ala Asn Thr Ile Leu 
    290                 295                 300                 


Leu Thr Lys Phe Phe Met Leu Leu Thr Phe Pro Leu Ser Phe Pro Ile 
305                 310                 315                 320 


Ser Lys Leu Leu Asp Phe Phe Leu Gly Gln Glu Ile Arg Thr Val Tyr 
                325                 330                 335     


Asn Arg Glu Lys Leu Met Glu Met Leu Lys Val Thr Glu Pro Tyr Asn 
            340                 345                 350         


Asp Leu Val Lys Glu Glu Leu Asn Met Ile Gln Gly Ala Leu Glu Leu 
        355                 360                 365             


Arg Thr Lys Thr Val Glu Asp Ile Met Thr Gln Leu Gln Asp Cys Phe 
    370                 375                 380                 


Met Ile Arg Ser Asp Ala Ile Leu Asp Phe Asn Thr Met Ser Glu Ile 
385                 390                 395                 400 


Met Glu Ser Gly Tyr Thr Arg Ile Pro Val Phe Glu Asp Glu Gln Ser 
                405                 410                 415     


Asn Ile Val Asp Ile Leu Tyr Val Lys Asp Leu Ala Phe Val Asp Pro 
            420                 425                 430         


Asp Asp Cys Thr Pro Leu Lys Thr Ile Thr Arg Phe Tyr Asn His Pro 
        435                 440                 445             


Val His Phe Val Phe His Asp Thr Lys Leu Asp Ala Met Leu Glu Glu 
    450                 455                 460                 


Phe Lys Lys Gly Lys Ser His Leu Ala Ile Val Gln Lys Val Asn Asn 
465                 470                 475                 480 


Glu Gly Glu Gly Asp Pro Phe Tyr Glu Val Leu Gly Leu Val Thr Leu 
                485                 490                 495     


Glu Asp Val Ile Glu Glu Ile Ile Lys Ser Glu Ile Leu Asp Glu Ser 
            500                 505                 510         


Asp Met Tyr Thr Asp Asn Arg Ser Arg Lys Arg Val Ser Glu Lys Asn 
        515                 520                 525             


Lys Arg Asp Phe Ser Ala Phe Lys Asp Ala Asp Asn Glu Leu Lys Val 
    530                 535                 540                 


Lys Ile Ser Pro Gln Leu Leu Leu Ala Ala His Arg Phe Leu Ala Thr 
545                 550                 555                 560 


Glu Val Ser Gln Phe Ser Pro Ser Leu Ile Ser Glu Lys Ile Leu Leu 
                565                 570                 575     


Arg Leu Leu Lys Tyr Pro Asp Val Ile Gln Glu Leu Lys Phe Asp Glu 
            580                 585                 590         


His Asn Lys Tyr Tyr Ala Arg His Tyr Leu Tyr Thr Arg Asn Lys Pro 
        595                 600                 605             


Ala Asp Tyr Phe Ile Leu Ile Leu Gln Gly Lys Val Glu Val Glu Ala 
    610                 615                 620                 


Gly Lys Glu Asn Met Lys Phe Glu Thr Gly Ala Phe Ser Tyr Tyr Gly 
625                 630                 635                 640 


Thr Met Ala Leu Thr Ser Val Pro Ser Asp Arg Ser Pro Ala His Pro 
                645                 650                 655     


Thr Pro Leu Ser Arg Ser Ala Ser Leu Ser Tyr Pro Asp Arg Thr Asp 
            660                 665                 670         


Val Ser Thr Ala Ala Thr Leu Ala Gly Ser Ser Asn Gln Phe Gly Ser 
        675                 680                 685             


Ser Val Leu Gly Gln Tyr Ile Ser Asp Phe Ser Val Arg Ala Leu Val 
    690                 695                 700                 


Asp Leu Gln Tyr Ile Lys Ile Thr Arg Gln Gln Tyr Gln Asn Gly Leu 
705                 710                 715                 720 


Leu Ala Ser Arg Met Glu Asn Ser Pro Gln Phe Pro Ile Asp Gly Cys 
                725                 730                 735     


Thr Thr His Met Glu Asn Leu Ala Glu Lys Ser Glu Leu Pro Val Val 
            740                 745                 750         


Asp Glu Thr Thr Thr Leu Leu Asn Glu Arg Asn Ser Leu Leu His Lys 
        755                 760                 765             


Ala Ser His Glu Asn Ala Ile 
    770                 775 


<210>  535
<211>  4916
<212>  DNA
<213>  Homosapiens

<400>  535
gaggccgaga gggggcagca ggcgatggcg gcggcggtag ctgcggcggg tcggttaggc     60

tggttgttcg ccgcgctctg cctgggcaac gccgcggggg aggccgcgcc gggcccgcga    120

gtgctgggct tctgcctgga ggaggatgga gcggcgggcg cgggttgggt acgcggaggg    180

gcggcgcggg acacgccgga cgccaccttc ctcctgcgcc tcttcggccc gggcttcgcc    240

aacagctctt ggtcctgggt ggccccggag ggggcgggct gccgggagga ggcggcctcc    300

cccgcgggcg agtggcgcgc gctgctgcgc ttgcgcctgc gggccgaggc cgtgcgcccg    360

cactcggcgc tgctggcggt gcgcgtggag ccgggtggcg gggcggctga ggaggcggcg    420

ccgccctggg ctctgggcct gggggcggcc gggctgctgg cgctggcagc gctggcgcga    480

ggcctgcagc tgagcgcgct ggcgctggcg cctgccgagg tgcaggtgct gcgcgagagc    540

ggctcggagg cggagcgtgc ggcggcgcgg cgtttggagc ccgcgcggcg ctgggccggc    600

tgcgccttgg gcgcgctgct gctgctggcc agcctggcgc aggcggcgct ggcggtgctg    660

ctgtaccgcg cggccggcca gcgtgcggtg cccgccgtgt tgggcagcgc ggggctcgtg    720

ttcctggtgg gagaggtggt gccggccgcc gtgagcgggc gctggacgct ggcgctggcg    780

ccgcgagcgc tcggcctcag ccgcctggcc gtcctgctca ctctgcccgt cgcgctgccc    840

gtggggcagc tgctggagct ggcggcgcgg cccgggcggc tgcgggagcg ggtgctggag    900

ctggcgcgcg gcggcggcga cccctacagc gatctcagca agggcgtgct gcgctgccgg    960

accgtggagg acgtgctcac gcccctcgaa gactgcttca tgctggacgc cagcaccgtg   1020

ctggacttcg gcgtcctggc cagcatcatg cagagcggcc acacgcgcat cccggtgtac   1080

gaggaggagc gctccaacat cgtggacatg ctctacctca aggacttggc cttcgtggat   1140

cccgaagact gcacgccgct cagcaccatc actcgtttct acaaccatcc gctccacttc   1200

gtcttcaacg acaccaagct ggacgctgtc ctggaggaat tcaagcgagg gaagtcccac   1260

ctggccatcg tgcagaaggt gaacaacgag ggtgaaggcg accccttcta cgaggtcctg   1320

ggcctggtca ccctggagga cgtgatcgag gagatcatca ggtccgagat cctggacgag   1380

tctgaagact accgagacac cgtggtgaag aggaagcctg cttctctgat ggcccctctg   1440

aagcggaagg aggagttctc cttgttcaag gtgtctgatg atgaatataa agtaacaatc   1500

tcgcctcagc tgctcttggc cacccagcgc ttcctgtccc gagaagtgga tgtattcagc   1560

ccgctgcgca tctctgagaa ggtcctgctg cacctgttga agcatcccag tgtcaaccag   1620

gaagtgaggt ttgacgagag caaccggctg gccacacacc actacctgta ccagcgcagc   1680

cagccggtgg attacttcat tctcatcctg cagggcaggg ttgaagtgga gatcgggaaa   1740

gagggtctga agtttgagaa tggggccttc acgtactatg gagtgtcggc cctaactgtg   1800

ccatcctcgg ttcaccagtc cccggtgtcc tcgctccagc ccatccgcca tgacctgcag   1860

cccgacccag gtgacggcac gcattcatct gcgtattgtc ccgactacac cgtgagggcg   1920

ctctctgatc tgcagctcat caaggttacg cgactgcagt acctcaatgc actcctggct   1980

acccgagccc agaacctgcc acagtcccct gagaacaccg acctgcaggt tattccaggc   2040

agccagacca ggctccttgg tgagaagacc accacagcgg cagggtccag ccacagcagg   2100

cccggcgtcc cggtggaagg cagccctggg cggaacccag gcgtttaacg gctcactagg   2160

cagccccaga tctggggaac agatgagcac gtggggagct ggagtgagct gagcagaagt   2220

tttgtgcccg cctgccccca tcccctccag gccacgtttt agatggccct tgtagttgcg   2280

ggtcctgggt gtcctcagaa ctagacatca atgcctggat ccttcagccg gccctgccct   2340

cctttaggag acaggagtca ccagggcaca gccctccagg cccgcctcag gaaggaatga   2400

aaggaatgcc atcatctcta gttcccaggg cccagccttc cccttctccc ccggggcagg   2460

gacagtgcgg catattcaga ttcagacctc tttgggctga gccaccttgt gagtgcagtt   2520

actgcctttg tgtggccgtg acctctattt gtttgctttt aatttgccaa cctatcgctg   2580

ctggcagcac tttttgagca agccgagagc acccattttg gctgggggtt cagatcgatg   2640

gccttgtcca tgttgtcctt tctggcttcc ctgatggtgt catgtttcag cgcatgcgcc   2700

ccagcctttc ccatgtgcca aaccagaagc tccactgccc gtaggctgtc cctgtagccc   2760

tgctccctcc ctggaggctg ctcttctgat tctgagagct ggcctagtgg tgctgagggc   2820

ccctttctgc ttctctgccc acctgctgag ttgccactcg cagtgttgtc agttcccgtg   2880

ttctgagaag aggtcatgcc tgggaggaag ggatcgtcat gctgcatcga atcctctctc   2940

cgccgtgtgg cccccaggag agtagctgcc tgttgcacct gctccacacc tccccacagc   3000

ctccctgcag gtgctgtgtg gccgtgatgt gcagagagca gtgagggagg gttcatgaac   3060

caggtggatc ctctttaaaa aaaaaaaagt ttttgttata tctctagaac atttcaagtc   3120

ttttcctttt tttctgttcc tagctatggg gttttagaga agtgggaaca ggaaggcatt   3180

tgtctttttc ttctagttta ctacattttc cttccgtagt tcttcagctg tgtggaaacg   3240

ggcatcacaa ggacatagga tcatagattg ggtagggagg gaggaggatt tctggaactt   3300

ttctcaaagg aatttggacc cttataaatg ggactgaagg tcaaaacaac agtgatatcc   3360

ttgcttagaa attgtcctca aggaataaac tctgagagca agcccgggtt ggaaacagat   3420

gctttaaaat cctctctcca gaacagtggt tttttgtttg tttatttgag atggagtctc   3480

actctgtcac ccaggctgga gtgcagtggt gagatcttgg ctcactgcaa cctccacctc   3540

ccaggttcaa gccattctcc tgtctcagcc ccctgagtag ctgggattac aggtgcccac   3600

caccacaccc ggctaatttt tgtattttta gtagagatgg ggtttcacca tgttggccag   3660

gctgatcttg aactcctgac ctcaggtgat ctgcctgcct tggcctccca aagtgctggg   3720

attataggtg tgagctaaga tcagggattc ttaaccttgg ctgcacacca gaatcacctg   3780

gcaaattaaa aatacgtgga cctgccacca gagcttgtga tttaatcaga gtcggcatca   3840

gagttttcaa ttttttattt atttattatt attattatta ttattattat tattgagaca   3900

agatcttgct ctgtcgccca gactggagtg cagtggtgtg atcacggctt gctgcagcct   3960

cgacctccct ggttcaggcc atcctgccac ctcagcctcc tgagtagtag ggactacagg   4020

taggcaccac cacacccagc taatactttt aatttttttt tgtagagata gggtctcatt   4080

atgttgcctg gggtagtctc gaactcctag gctcaagcga tcctcctgcc tcggcctccc   4140

aaagtgttga gattataggc gtgagccacc gtgcccagat tcacagaagt ttcatacacc   4200

tttcacccag gttcccctaa tgttaacagc ttacatataa ccttggtaca tttatcaaaa   4260

ctaaaggtgc aatcatacta atagctagag tttatttgga ttttaccatt tttcccaatg   4320

tcccttttct gctgcagcag ccaatccagg atgccatact gcacttagag ctgttgcttt   4380

cttttttcct aactttatat tttgaaataa tttcagatga taggaagttg taaaggtaag   4440

ggccccacgc acccttcatc tagtttccct ccatggttac atcttatatg gttgtaatgc   4500

agtattccaa caaagactct gacactggtg cgatgtgggt ggacagtcca aatcatttgt   4560

cacatgtaca tctgtgtaac taccactgca atcaggataa agaagtccca tccccacaag   4620

gatctccctc cccaccttcc ctaactcctg gtaaccacta atcgttcatc tcttcttatt   4680

ttgtcatttc aagaatgttg tataaatggg agcatagtgt gtaagcattc gggattgtct   4740

tttttcactc ggcgtcattc tcgggagatc atccaggcat tgcatgtgtc aacagtttgc   4800

tcctttttat tgctgagtgg tattccgtgg tgtatgcatt ggccccctga aggacacctg   4860

ggatgtttcc agtttggggc tattccaaat aaagctgcta cgactattca tgtaca       4916


<210>  536
<211>  707
<212>  PRT
<213>  Homosapiens

<400>  536

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Lys Ser His Leu Ala Ile Val 
                405                 410                 415     


Gln Lys Val Asn Asn Glu Gly Glu Gly Asp Pro Phe Tyr Glu Val Leu 
            420                 425                 430         


Gly Leu Val Thr Leu Glu Asp Val Ile Glu Glu Ile Ile Arg Ser Glu 
        435                 440                 445             


Ile Leu Asp Glu Ser Glu Asp Tyr Arg Asp Thr Val Val Lys Arg Lys 
    450                 455                 460                 


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
465                 470                 475                 480 


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
                485                 490                 495     


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
            500                 505                 510         


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
        515                 520                 525             


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
    530                 535                 540                 


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
545                 550                 555                 560 


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
                565                 570                 575     


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
            580                 585                 590         


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
        595                 600                 605             


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
    610                 615                 620                 


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
625                 630                 635                 640 


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
                645                 650                 655     


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
            660                 665                 670         


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
        675                 680                 685             


Ser His Ser Arg Pro Gly Val Pro Val Glu Gly Ser Pro Gly Arg Asn 
    690                 695                 700                 


Pro Gly Val 
705         


<210>  537
<211>  4772
<212>  DNA
<213>  Homosapiens

<400>  537
gaggccgaga gggggcagca ggcgatggcg gcggcggtag ctgcggcggg tcggttaggc     60

tggttgttcg ccgcgctctg cctgggcaac gccgcggggg aggccgcgcc gggcccgcga    120

gtgctgggct tctgcctgga ggaggatgga gcggcgggcg cgggttgggt acgcggaggg    180

gcggcgcggg acacgccgga cgccaccttc ctcctgcgcc tcttcggccc gggcttcgcc    240

aacagctctt ggtcctgggt ggccccggag ggggcgggct gccgggagga ggcggcctcc    300

cccgcgggcg agtggcgcgc gctgctgcgc ttgcgcctgc gggccgaggc cgtgcgcccg    360

cactcggcgc tgctggcggt gcgcgtggag ccgggtggcg gggcggctga ggaggcggcg    420

ccgccctggg ctctgggcct gggggcggcc gggctgctgg cgctggcagc gctggcgcga    480

ggcctgcagc tgagcgcgct ggcgctggcg cctgccgagg tgcaggtgct gcgcgagagc    540

ggctcggagg cggagcgtgc ggcggcgcgg cgtttggagc ccgcgcggcg ctgggccggc    600

tgcgccttgg gcgcgctgct gctgctggcc agcctggcgc aggcggcgct ggcggtgctg    660

ctgtaccgcg cggccggcca gcgtgcggtg cccgccgtgt tgggcagcgc ggggctcgtg    720

ttcctggtgg gagaggtggt gccggccgcc gtgagcgggc gctggacgct ggcgctggcg    780

ccgcgagcgc tcggcctcag ccgcctggcc gtcctgctca ctctgcccgt cgcgctgccc    840

gtggggcagc tgctggagct ggcggcgcgg cccgggcggc tgcgggagcg ggtgctggag    900

ctggcgcgcg gcggcggcga cccctacagc gatctcagca agggcgtgct gcgctgccgg    960

accgtggagg acgtgctcac gcccctcgaa gactgcttca tgctggacgc cagcaccgtg   1020

ctggacttcg gcgtcctggc cagcatcatg cagagcggcc acacgcgcat cccggtgtac   1080

gaggaggagc gctccaacat cgtggacatg ctctacctca aggacttggc cttcgtggat   1140

cccgaagact gcacgccgct cagcaccatc actcgtttct acaaccatcc gctccacttc   1200

gtcttcaacg acaccaagct ggacgctgtc ctggaggaat tcaagcgagg agacaccgtg   1260

gtgaagagga agcctgcttc tctgatggcc cctctgaagc ggaaggagga gttctccttg   1320

ttcaaggtgt ctgatgatga atataaagta acaatctcgc ctcagctgct cttggccacc   1380

cagcgcttcc tgtcccgaga agtggatgta ttcagcccgc tgcgcatctc tgagaaggtc   1440

ctgctgcacc tgttgaagca tcccagtgtc aaccaggaag tgaggtttga cgagagcaac   1500

cggctggcca cacaccacta cctgtaccag cgcagccagc cggtggatta cttcattctc   1560

atcctgcagg gcagggttga agtggagatc gggaaagagg gtctgaagtt tgagaatggg   1620

gccttcacgt actatggagt gtcggcccta actgtgccat cctcggttca ccagtccccg   1680

gtgtcctcgc tccagcccat ccgccatgac ctgcagcccg acccaggtga cggcacgcat   1740

tcatctgcgt attgtcccga ctacaccgtg agggcgctct ctgatctgca gctcatcaag   1800

gttacgcgac tgcagtacct caatgcactc ctggctaccc gagcccagaa cctgccacag   1860

tcccctgaga acaccgacct gcaggttatt ccaggcagcc agaccaggct ccttggtgag   1920

aagaccacca cagcggcagg gtccagccac agcaggcccg gcgtcccggt ggaaggcagc   1980

cctgggcgga acccaggcgt ttaacggctc actaggcagc cccagatctg gggaacagat   2040

gagcacgtgg ggagctggag tgagctgagc agaagttttg tgcccgcctg cccccatccc   2100

ctccaggcca cgttttagat ggcccttgta gttgcgggtc ctgggtgtcc tcagaactag   2160

acatcaatgc ctggatcctt cagccggccc tgccctcctt taggagacag gagtcaccag   2220

ggcacagccc tccaggcccg cctcaggaag gaatgaaagg aatgccatca tctctagttc   2280

ccagggccca gccttcccct tctcccccgg ggcagggaca gtgcggcata ttcagattca   2340

gacctctttg ggctgagcca ccttgtgagt gcagttactg cctttgtgtg gccgtgacct   2400

ctatttgttt gcttttaatt tgccaaccta tcgctgctgg cagcactttt tgagcaagcc   2460

gagagcaccc attttggctg ggggttcaga tcgatggcct tgtccatgtt gtcctttctg   2520

gcttccctga tggtgtcatg tttcagcgca tgcgccccag cctttcccat gtgccaaacc   2580

agaagctcca ctgcccgtag gctgtccctg tagccctgct ccctccctgg aggctgctct   2640

tctgattctg agagctggcc tagtggtgct gagggcccct ttctgcttct ctgcccacct   2700

gctgagttgc cactcgcagt gttgtcagtt cccgtgttct gagaagaggt catgcctggg   2760

aggaagggat cgtcatgctg catcgaatcc tctctccgcc gtgtggcccc caggagagta   2820

gctgcctgtt gcacctgctc cacacctccc cacagcctcc ctgcaggtgc tgtgtggccg   2880

tgatgtgcag agagcagtga gggagggttc atgaaccagg tggatcctct ttaaaaaaaa   2940

aaaagttttt gttatatctc tagaacattt caagtctttt cctttttttc tgttcctagc   3000

tatggggttt tagagaagtg ggaacaggaa ggcatttgtc tttttcttct agtttactac   3060

attttccttc cgtagttctt cagctgtgtg gaaacgggca tcacaaggac ataggatcat   3120

agattgggta gggagggagg aggatttctg gaacttttct caaaggaatt tggaccctta   3180

taaatgggac tgaaggtcaa aacaacagtg atatccttgc ttagaaattg tcctcaagga   3240

ataaactctg agagcaagcc cgggttggaa acagatgctt taaaatcctc tctccagaac   3300

agtggttttt tgtttgttta tttgagatgg agtctcactc tgtcacccag gctggagtgc   3360

agtggtgaga tcttggctca ctgcaacctc cacctcccag gttcaagcca ttctcctgtc   3420

tcagccccct gagtagctgg gattacaggt gcccaccacc acacccggct aatttttgta   3480

tttttagtag agatggggtt tcaccatgtt ggccaggctg atcttgaact cctgacctca   3540

ggtgatctgc ctgccttggc ctcccaaagt gctgggatta taggtgtgag ctaagatcag   3600

ggattcttaa ccttggctgc acaccagaat cacctggcaa attaaaaata cgtggacctg   3660

ccaccagagc ttgtgattta atcagagtcg gcatcagagt tttcaatttt ttatttattt   3720

attattatta ttattattat tattattatt gagacaagat cttgctctgt cgcccagact   3780

ggagtgcagt ggtgtgatca cggcttgctg cagcctcgac ctccctggtt caggccatcc   3840

tgccacctca gcctcctgag tagtagggac tacaggtagg caccaccaca cccagctaat   3900

acttttaatt tttttttgta gagatagggt ctcattatgt tgcctggggt agtctcgaac   3960

tcctaggctc aagcgatcct cctgcctcgg cctcccaaag tgttgagatt ataggcgtga   4020

gccaccgtgc ccagattcac agaagtttca tacacctttc acccaggttc ccctaatgtt   4080

aacagcttac atataacctt ggtacattta tcaaaactaa aggtgcaatc atactaatag   4140

ctagagttta tttggatttt accatttttc ccaatgtccc ttttctgctg cagcagccaa   4200

tccaggatgc catactgcac ttagagctgt tgctttcttt tttcctaact ttatattttg   4260

aaataatttc agatgatagg aagttgtaaa ggtaagggcc ccacgcaccc ttcatctagt   4320

ttccctccat ggttacatct tatatggttg taatgcagta ttccaacaaa gactctgaca   4380

ctggtgcgat gtgggtggac agtccaaatc atttgtcaca tgtacatctg tgtaactacc   4440

actgcaatca ggataaagaa gtcccatccc cacaaggatc tccctcccca ccttccctaa   4500

ctcctggtaa ccactaatcg ttcatctctt cttattttgt catttcaaga atgttgtata   4560

aatgggagca tagtgtgtaa gcattcggga ttgtcttttt tcactcggcg tcattctcgg   4620

gagatcatcc aggcattgca tgtgtcaaca gtttgctcct ttttattgct gagtggtatt   4680

ccgtggtgta tgcattggcc ccctgaagga cacctgggat gtttccagtt tggggctatt   4740

ccaaataaag ctgctacgac tattcatgta ca                                 4772


<210>  538
<211>  659
<212>  PRT
<213>  Homosapiens

<400>  538

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Asp Thr Val Val Lys Arg Lys 
                405                 410                 415     


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
            420                 425                 430         


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
        435                 440                 445             


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
    450                 455                 460                 


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
465                 470                 475                 480 


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
                485                 490                 495     


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
            500                 505                 510         


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
        515                 520                 525             


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
    530                 535                 540                 


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
545                 550                 555                 560 


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
                565                 570                 575     


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
            580                 585                 590         


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
        595                 600                 605             


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
    610                 615                 620                 


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
625                 630                 635                 640 


Ser His Ser Arg Pro Gly Val Pro Val Glu Gly Ser Pro Gly Arg Asn 
                645                 650                 655     


Pro Gly Val 
            


<210>  539
<211>  2591
<212>  DNA
<213>  Homosapiens

<400>  539
actggggggt gtgaggaaca ggggggacca tggacttcat cagcattcag cagttggtaa     60

gtggagaaag agttgaaggg aaagtgttgg gatttggaca tggagttcct gaccctggag    120

cctggcctag tgactggagg aggggccccc aagaggctgt ggcccgggag aagctgaaat    180

tggaagaaga gaagaagaag aaacttgaaa gatttaacag taccagattt aatctggata    240

acctggctga cttggaaaac ttggttcaaa gacggaaaaa gcgactgaga cacagagtcc    300

cccccaggaa acctgagccc ctggttaagc cgcagtccca ggcccaggtg gagcctgtgg    360

gcctggagat gttcctgaag gcagctgctg agaaccagga gtacctgatt gacaagtact    420

tgacagacgg aggggacccc aatgcccatg acaagctcca ccgcaccgcc ttgcactggg    480

cctgtctgaa gggtcacagc cagctggtga acaagctgct ggtggcaggt gccacagtgg    540

acgcgcgaga cttgctggac aggacacctg tgttctgggc ctgccgcgga ggacatctgg    600

tcatcctcaa acagctgctt aaccagggag cccgggtcaa tgcccgggac aagatcggga    660

gcacccccct gcacgtggca gtgcgcaccc ggcaccccga ctgcctggag cacctcatcg    720

agtgtggcgc ccacctgaac gcacaggata aggaagggga cacggctctg cacgaggccg    780

tgcggcacgg cagctacaaa gccatgaagc tactgctgct ctatggggcc gagctggggg    840

tgcggaacgc ggcctccgtg accccggtgc agctggctcg agactggcag cgcggcatcc    900

gggaggccct gcaggcccac gtggcgcatc cccgcacccg gtgctgaccg cagcaccgcc    960

ccccgccgcg cctttcgcac tgccaccatt ccatcctgtg ccccgccccc gcgtctgcac   1020

ctctgtggtt cctgccctca gccctggttc ctccctctct ggcctgtgcc gcctcagcag   1080

ccctggcaga actgaagagc ggcaccgggc ccagcaggca aagagagagg cctccctggc   1140

ttcgagtgtc aggggagccg cgttccctcc cagggctgga gcagaggacc acaaggcagc   1200

agaaagcgcg ggtccagatg agggccagga aggggaggag agtgagggcc aagaacgagc   1260

cttaagggag cagtcccaag ctggagccac ccagggctgg gtctgggagt cctcagtgtc   1320

cacttgtccc aggttagggg gcttgccttg ctctctccag ggccagtctg tgtgtgtggg   1380

gactcagccc gtggccggca gatgccatcc aggatgtaca aggtgcagcc aaggcaggcc   1440

atgcaggggc cgggcctgtc tgcagctggt ggatgcctgt gggcatggct ttctctgggg   1500

accccattcc tgtcagtagc aaccctggca gtgtccggag cggctctaga caactttggt   1560

cataggaact ctggaggtgg gttctggtca tctgaggtgg ctactcaaca ggtttgaggc   1620

cccacagcaa cagaagtcca ggacccacta ggttgcctca gaagccctaa gactgatgag   1680

ctggagcgcg catttgagag aagcctcgca cccactgtgt actggccccg ctcaggccgg   1740

cctggcacac cgttgcctgc tggcggctct catggggaag cgcctgggca ctggggattg   1800

cttgtggccc actcaactct tggggcagtg gcccgtaacc ctagtttgcc tgaggccctt   1860

atgtcccctt atgttcctgg tactggagct tgagctcttg cctggaacgc tgcagctgca   1920

cccaccctgc ttgatcccac ctgggaggcc aggacactga ggagctctga acccagccca   1980

cagggaagca gaggaaggtg agcccccgcc gccccccagc ccttcccatc ccttccctgc   2040

tccctggtgg tctaaggacc caagctccct agacttcctc ttccaccgtc tgtacgtttc   2100

aaattacact ggtgtaggcc tgtactgctg gtggggctgg gcccctaaac gccagaaagt   2160

gaatcttaag aagctctgcc ctaaactgag aaccacatgc tgagggaagg gctgaaaggt   2220

gaaggctcag cctccctcac atgggtcctg ggttacatta ggtaccgggc tgattgatag   2280

gcatttggcc atggttcctt ttcgtctacc tttgggggcc ttctcaggcc cagaacaagg   2340

ctgttgttac tatgtggaaa agctgaccag tgctgcacac taggggcaca cacctttcca   2400

tgagcagctc ctgccctgtg gcgacagcca gcgtgcaccc agacgctggt gccatggcga   2460

agcaggcgtt caagaccatg gagaagacaa ctcctcatct agaaaatgag gacacctcag   2520

tgacaaacac acctttttat accaatcagt atcctctgtt cattaaaact ggctatccat   2580

taaaaaaaaa a                                                        2591


<210>  540
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  540

Met Asp Phe Ile Ser Ile Gln Gln Leu Val Ser Gly Glu Arg Val Glu 
1               5                   10                  15      


Gly Lys Val Leu Gly Phe Gly His Gly Val Pro Asp Pro Gly Ala Trp 
            20                  25                  30          


Pro Ser Asp Trp Arg Arg Gly Pro Gln Glu Ala Val Ala Arg Glu Lys 
        35                  40                  45              


Leu Lys Leu Glu Glu Glu Lys Lys Lys Lys Leu Glu Arg Phe Asn Ser 
    50                  55                  60                  


Thr Arg Phe Asn Leu Asp Asn Leu Ala Asp Leu Glu Asn Leu Val Gln 
65                  70                  75                  80  


Arg Arg Lys Lys Arg Leu Arg His Arg Val Pro Pro Arg Lys Pro Glu 
                85                  90                  95      


Pro Leu Val Lys Pro Gln Ser Gln Ala Gln Val Glu Pro Val Gly Leu 
            100                 105                 110         


Glu Met Phe Leu Lys Ala Ala Ala Glu Asn Gln Glu Tyr Leu Ile Asp 
        115                 120                 125             


Lys Tyr Leu Thr Asp Gly Gly Asp Pro Asn Ala His Asp Lys Leu His 
    130                 135                 140                 


Arg Thr Ala Leu His Trp Ala Cys Leu Lys Gly His Ser Gln Leu Val 
145                 150                 155                 160 


Asn Lys Leu Leu Val Ala Gly Ala Thr Val Asp Ala Arg Asp Leu Leu 
                165                 170                 175     


Asp Arg Thr Pro Val Phe Trp Ala Cys Arg Gly Gly His Leu Val Ile 
            180                 185                 190         


Leu Lys Gln Leu Leu Asn Gln Gly Ala Arg Val Asn Ala Arg Asp Lys 
        195                 200                 205             


Ile Gly Ser Thr Pro Leu His Val Ala Val Arg Thr Arg His Pro Asp 
    210                 215                 220                 


Cys Leu Glu His Leu Ile Glu Cys Gly Ala His Leu Asn Ala Gln Asp 
225                 230                 235                 240 


Lys Glu Gly Asp Thr Ala Leu His Glu Ala Val Arg His Gly Ser Tyr 
                245                 250                 255     


Lys Ala Met Lys Leu Leu Leu Leu Tyr Gly Ala Glu Leu Gly Val Arg 
            260                 265                 270         


Asn Ala Ala Ser Val Thr Pro Val Gln Leu Ala Arg Asp Trp Gln Arg 
        275                 280                 285             


Gly Ile Arg Glu Ala Leu Gln Ala His Val Ala His Pro Arg Thr Arg 
    290                 295                 300                 


Cys 
305 


<210>  541
<211>  852
<212>  DNA
<213>  Homosapiens

<400>  541
ggatcgactg acgccggggc cgggatggcg acgcctcggc cctgcgcgga cgggccctgc     60

tgctcgcatc ccagcgcggt gctcggcgta cagcagacgc tggaggagat ggacttcgag    120

aggggaatct ggtcggcagc cctgaatgga gacctgggcc gagtgaagca tttaatccag    180

aaggccgagg acccaagtca gcccgactcg gccggctaca ctgcgctgca ctatgccagc    240

cgcaatgggc actacgctgt gtgccagttc ctgctggaaa gcggagctaa gtgtgatgcc    300

cagacccacg ggggtgccac tgctctgcac cgagccagct actgcgggca cactgaaatc    360

acgcggctcc tgctatcaca tgggtccaac cccagggtgg tggatgacga cggcatgacc    420

agtctgcata aggctgctga gaggggtcac ggggacatct gctccctcct cctgcaacac    480

agcccagccc tgaaggccat ccgggaccga aaggcacggc tagcatgtga cctgctgcct    540

tgcaacagtg acctgcggga cctgctatcc agctgagccg ccaccctatc tccagctgcc    600

tttaaagggt acacagacca gttctccaag cccctgcctt ggtcagcatc catgctgctg    660

ggcagggaac tgaggccaga ccacccagga agagccccag tctggtcact gtggaagcga    720

gggagtagat ttggtgtggc taaaagtgtt taagactgga cagatgatca tattctaaat    780

tagttcatat gagacatcta tttatttgga aaaaaataaa gttatatcct taccccaaaa    840

aaaaaaaaaa aa                                                        852


<210>  542
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  542

Met Ala Thr Pro Arg Pro Cys Ala Asp Gly Pro Cys Cys Ser His Pro 
1               5                   10                  15      


Ser Ala Val Leu Gly Val Gln Gln Thr Leu Glu Glu Met Asp Phe Glu 
            20                  25                  30          


Arg Gly Ile Trp Ser Ala Ala Leu Asn Gly Asp Leu Gly Arg Val Lys 
        35                  40                  45              


His Leu Ile Gln Lys Ala Glu Asp Pro Ser Gln Pro Asp Ser Ala Gly 
    50                  55                  60                  


Tyr Thr Ala Leu His Tyr Ala Ser Arg Asn Gly His Tyr Ala Val Cys 
65                  70                  75                  80  


Gln Phe Leu Leu Glu Ser Gly Ala Lys Cys Asp Ala Gln Thr His Gly 
                85                  90                  95      


Gly Ala Thr Ala Leu His Arg Ala Ser Tyr Cys Gly His Thr Glu Ile 
            100                 105                 110         


Thr Arg Leu Leu Leu Ser His Gly Ser Asn Pro Arg Val Val Asp Asp 
        115                 120                 125             


Asp Gly Met Thr Ser Leu His Lys Ala Ala Glu Arg Gly His Gly Asp 
    130                 135                 140                 


Ile Cys Ser Leu Leu Leu Gln His Ser Pro Ala Leu Lys Ala Ile Arg 
145                 150                 155                 160 


Asp Arg Lys Ala Arg Leu Ala Cys Asp Leu Leu Pro Cys Asn Ser Asp 
                165                 170                 175     


Leu Arg Asp Leu Leu Ser Ser 
            180             


<210>  543
<211>  3537
<212>  DNA
<213>  Homosapiens

<400>  543
gcgagcgcgg gcaggcggcg acgcgggggc aggggtggac ggcggtcaga gccgaacgcg     60

agggcggcgc ccggggactg gagctgcgcg caataggaca gctggcctga agctcagagc    120

cggggcgtgc gccatggccc cacactgggc tgtctggctg ctggcagcaa ggctgtgggg    180

cctgggcatt ggggctgagg tgtggtggaa ccttgtgccg cgtaagacag tgtcttctgg    240

ggagctggcc acggtagtac ggcggttctc ccagaccggc atccaggact tcctgacact    300

gacgctgacg gagcccactg ggcttctgta cgtgggcgcc cgagaggccc tgtttgcctt    360

cagcatggag gccctggagc tgcaaggagc gatctcctgg gaggcccccg tggagaagaa    420

gactgagtgt atccagaaag ggaagaacaa ccagaccgag tgcttcaact tcatccgctt    480

cctgcagccc tacaatgcct cccacctgta cgtctgtggc acctacgcct tccagcccaa    540

gtgcacctac gtcaacatgc tcaccttcac tttggagcat ggagagtttg aagatgggaa    600

gggcaagtgt ccctatgacc cagctaaggg ccatgctggc cttcttgtgg atggtgagct    660

gtactcggcc acactcaaca acttcctggg cacggaaccc attatcctgc gtaacatggg    720

gccccaccac tccatgaaga cagagtacct ggccttttgg ctcaacgaac ctcactttgt    780

aggctctgcc tatgtacctg agagtgtggg cagcttcacg ggggacgacg acaaggtcta    840

cttcttcttc agggagcggg cagtggagtc cgactgctat gccgagcagg tggtggctcg    900

tgtggcccgt gtctgcaagg gcgatatggg gggcgcacgg accctgcaga ggaagtggac    960

cacgttcctg aaggcgcggc tggcatgctc tgccccgaac tggcagctct acttcaacca   1020

gctgcaggcg atgcacaccc tgcaggacac ctcctggcac aacaccacct tctttggggt   1080

ttttcaagca cagtggggtg acatgtacct gtcggccatc tgtgagtacc agttggaaga   1140

gatccagcgg gtgtttgagg gcccctataa ggagtaccat gaggaagccc agaagtggga   1200

ccgctacact gaccctgtac ccagccctcg gcctggctcg tgcattaaca actggcatcg   1260

gcgccacggc tacaccagct ccctggagct acccgacaac atcctcaact tcgtcaagaa   1320

gcacccgctg atggaggagc aggtggggcc tcggtggagc cgccccctgc tcgtgaagaa   1380

gggcaccaac ttcacccacc tggtggccga ccgggttaca ggacttgatg gagccaccta   1440

tacagtgctg ttcattggca caggagacgg ctggctgctc aaggctgtga gcctggggcc   1500

ctgggttcac ctgattgagg agctgcagct gtttgaccag gagcccatga gaagcctggt   1560

gctatctcag agcaagaagc tgctctttgc cggctcccgc tctcagctgg tgcagctgcc   1620

cgtggccgac tgcatgaagt atcgctcctg tgcagactgt gtcctcgccc gggaccccta   1680

ttgcgcctgg agcgtcaaca ccagccgctg tgtggccgtg ggtggccact ctggatctct   1740

actgatccag catgtgatga cctcggacac ttcaggcatc tgcaacctcc gtggcagtaa   1800

gaaagtcagg cccactccca aaaacatcac ggtggtggcg ggcacagacc tggtgctgcc   1860

ctgccacctc tcctccaact tggcccatgc ccgctggacc tttgggggcc gggacctgcc   1920

tgcggaacag cccgggacct tcctctacga tgcccggctc caggccctgg ttgtgatggc   1980

tgcccagccc cgccatgccg gggcctacca ctgcttttca gaggagcagg gggcgcggct   2040

ggctgctgaa ggctaccttg tggctgtcgt ggcaggcccg tcggtgacct tggaggcccg   2100

ggcccccctg gaaaacctgg ggctggtgtg gctggcggtg gtggccctgg gggctgtgtg   2160

cctggtgctg ctgctgctgg tgctgtcatt gcgccggcgg ctgcgggaag agctggagaa   2220

aggggccaag gctactgaga ggaccttggt gtaccccctg gagctgccca aggagcccac   2280

cagtcccccc ttccggccct gtcctgaacc agatgagaaa ctttgggatc ctgtcggtta   2340

ctactattca gatggctccc ttaagatagt acctgggcat gcccggtgcc agcccggtgg   2400

ggggccccct tcgccacctc caggcatccc aggccagcct ctgccttctc caactcggct   2460

tcacctgggg ggtgggcgga actcaaatgc caatggttac gtgcgcttac aactaggagg   2520

ggaggaccgg ggagggctcg ggcaccccct gcctgagctc gcggatgaac tgagacgcaa   2580

actgcagcaa cgccagccac tgcccgactc caaccccgag gagtcatcag tatgagggga   2640

acccccaccg cgtcggcggg aagcgtggga ggtgtagctc ctacttttgc acaggcacca   2700

gctacctcag ggacatggca cgggcacctg ctctgtctgg gacagatact gcccagcacc   2760

cacccggcca tgaggacctg ctctgctcag cacgggcact gccacttggt gtggctcacc   2820

agggcaccag cctcgcagaa ggcatcttcc tcctctctgt gaatcacaga cacgcgggac   2880

cccagccgcc aaaacttttc aaggcagaag tttcaagatg tgtgtttgtc tgtatttgca   2940

catgtgtttg tgtgtgtgtg tatgtgtgtg tgcacgcgcg tgcgcgcttg tggcatagcc   3000

ttcctgtttc tgtcaagtct tcccttggcc tgggtcctcc tggtgagtca ttggagctat   3060

gaaggggaag gggtcgtatc actttgtctc tcctaccccc actgccccga gtgtcgggca   3120

gcgatgtaca tatggaggtg gggtggacag ggtgctgtgc cccttcagag ggagtgcagg   3180

gcttggggtg ggcctagtcc tgctcctagg gctgtgaatg ttttcagggt ggggggaggg   3240

agatggagcc tcctgtgtgt ttggggggaa gggtgggtgg ggcctcccac ttggccccgg   3300

ggttcagtgg tattttatac ttgccttctt cctgtacagg gctgggaaag gctgtgtgag   3360

gggagagaag ggagagggtg ggcctgctgt ggacaatggc atactctctt ccagccctag   3420

gaggagggct cctaacagtg taacttattg tgtccccgcg tatttatttg ttgtaaatat   3480

ttgagtattt ttatattgac aaataaaatg gagaaaatga aaaaaaaaaa aaaaaaa      3537


<210>  544
<211>  833
<212>  PRT
<213>  Homosapiens

<400>  544

Met Ala Pro His Trp Ala Val Trp Leu Leu Ala Ala Arg Leu Trp Gly 
1               5                   10                  15      


Leu Gly Ile Gly Ala Glu Val Trp Trp Asn Leu Val Pro Arg Lys Thr 
            20                  25                  30          


Val Ser Ser Gly Glu Leu Ala Thr Val Val Arg Arg Phe Ser Gln Thr 
        35                  40                  45              


Gly Ile Gln Asp Phe Leu Thr Leu Thr Leu Thr Glu Pro Thr Gly Leu 
    50                  55                  60                  


Leu Tyr Val Gly Ala Arg Glu Ala Leu Phe Ala Phe Ser Met Glu Ala 
65                  70                  75                  80  


Leu Glu Leu Gln Gly Ala Ile Ser Trp Glu Ala Pro Val Glu Lys Lys 
                85                  90                  95      


Thr Glu Cys Ile Gln Lys Gly Lys Asn Asn Gln Thr Glu Cys Phe Asn 
            100                 105                 110         


Phe Ile Arg Phe Leu Gln Pro Tyr Asn Ala Ser His Leu Tyr Val Cys 
        115                 120                 125             


Gly Thr Tyr Ala Phe Gln Pro Lys Cys Thr Tyr Val Asn Met Leu Thr 
    130                 135                 140                 


Phe Thr Leu Glu His Gly Glu Phe Glu Asp Gly Lys Gly Lys Cys Pro 
145                 150                 155                 160 


Tyr Asp Pro Ala Lys Gly His Ala Gly Leu Leu Val Asp Gly Glu Leu 
                165                 170                 175     


Tyr Ser Ala Thr Leu Asn Asn Phe Leu Gly Thr Glu Pro Ile Ile Leu 
            180                 185                 190         


Arg Asn Met Gly Pro His His Ser Met Lys Thr Glu Tyr Leu Ala Phe 
        195                 200                 205             


Trp Leu Asn Glu Pro His Phe Val Gly Ser Ala Tyr Val Pro Glu Ser 
    210                 215                 220                 


Val Gly Ser Phe Thr Gly Asp Asp Asp Lys Val Tyr Phe Phe Phe Arg 
225                 230                 235                 240 


Glu Arg Ala Val Glu Ser Asp Cys Tyr Ala Glu Gln Val Val Ala Arg 
                245                 250                 255     


Val Ala Arg Val Cys Lys Gly Asp Met Gly Gly Ala Arg Thr Leu Gln 
            260                 265                 270         


Arg Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ala Cys Ser Ala Pro 
        275                 280                 285             


Asn Trp Gln Leu Tyr Phe Asn Gln Leu Gln Ala Met His Thr Leu Gln 
    290                 295                 300                 


Asp Thr Ser Trp His Asn Thr Thr Phe Phe Gly Val Phe Gln Ala Gln 
305                 310                 315                 320 


Trp Gly Asp Met Tyr Leu Ser Ala Ile Cys Glu Tyr Gln Leu Glu Glu 
                325                 330                 335     


Ile Gln Arg Val Phe Glu Gly Pro Tyr Lys Glu Tyr His Glu Glu Ala 
            340                 345                 350         


Gln Lys Trp Asp Arg Tyr Thr Asp Pro Val Pro Ser Pro Arg Pro Gly 
        355                 360                 365             


Ser Cys Ile Asn Asn Trp His Arg Arg His Gly Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Glu Leu Pro Asp Asn Ile Leu Asn Phe Val Lys Lys His Pro Leu Met 
385                 390                 395                 400 


Glu Glu Gln Val Gly Pro Arg Trp Ser Arg Pro Leu Leu Val Lys Lys 
                405                 410                 415     


Gly Thr Asn Phe Thr His Leu Val Ala Asp Arg Val Thr Gly Leu Asp 
            420                 425                 430         


Gly Ala Thr Tyr Thr Val Leu Phe Ile Gly Thr Gly Asp Gly Trp Leu 
        435                 440                 445             


Leu Lys Ala Val Ser Leu Gly Pro Trp Val His Leu Ile Glu Glu Leu 
    450                 455                 460                 


Gln Leu Phe Asp Gln Glu Pro Met Arg Ser Leu Val Leu Ser Gln Ser 
465                 470                 475                 480 


Lys Lys Leu Leu Phe Ala Gly Ser Arg Ser Gln Leu Val Gln Leu Pro 
                485                 490                 495     


Val Ala Asp Cys Met Lys Tyr Arg Ser Cys Ala Asp Cys Val Leu Ala 
            500                 505                 510         


Arg Asp Pro Tyr Cys Ala Trp Ser Val Asn Thr Ser Arg Cys Val Ala 
        515                 520                 525             


Val Gly Gly His Ser Gly Ser Leu Leu Ile Gln His Val Met Thr Ser 
    530                 535                 540                 


Asp Thr Ser Gly Ile Cys Asn Leu Arg Gly Ser Lys Lys Val Arg Pro 
545                 550                 555                 560 


Thr Pro Lys Asn Ile Thr Val Val Ala Gly Thr Asp Leu Val Leu Pro 
                565                 570                 575     


Cys His Leu Ser Ser Asn Leu Ala His Ala Arg Trp Thr Phe Gly Gly 
            580                 585                 590         


Arg Asp Leu Pro Ala Glu Gln Pro Gly Thr Phe Leu Tyr Asp Ala Arg 
        595                 600                 605             


Leu Gln Ala Leu Val Val Met Ala Ala Gln Pro Arg His Ala Gly Ala 
    610                 615                 620                 


Tyr His Cys Phe Ser Glu Glu Gln Gly Ala Arg Leu Ala Ala Glu Gly 
625                 630                 635                 640 


Tyr Leu Val Ala Val Val Ala Gly Pro Ser Val Thr Leu Glu Ala Arg 
                645                 650                 655     


Ala Pro Leu Glu Asn Leu Gly Leu Val Trp Leu Ala Val Val Ala Leu 
            660                 665                 670         


Gly Ala Val Cys Leu Val Leu Leu Leu Leu Val Leu Ser Leu Arg Arg 
        675                 680                 685             


Arg Leu Arg Glu Glu Leu Glu Lys Gly Ala Lys Ala Thr Glu Arg Thr 
    690                 695                 700                 


Leu Val Tyr Pro Leu Glu Leu Pro Lys Glu Pro Thr Ser Pro Pro Phe 
705                 710                 715                 720 


Arg Pro Cys Pro Glu Pro Asp Glu Lys Leu Trp Asp Pro Val Gly Tyr 
                725                 730                 735     


Tyr Tyr Ser Asp Gly Ser Leu Lys Ile Val Pro Gly His Ala Arg Cys 
            740                 745                 750         


Gln Pro Gly Gly Gly Pro Pro Ser Pro Pro Pro Gly Ile Pro Gly Gln 
        755                 760                 765             


Pro Leu Pro Ser Pro Thr Arg Leu His Leu Gly Gly Gly Arg Asn Ser 
    770                 775                 780                 


Asn Ala Asn Gly Tyr Val Arg Leu Gln Leu Gly Gly Glu Asp Arg Gly 
785                 790                 795                 800 


Gly Leu Gly His Pro Leu Pro Glu Leu Ala Asp Glu Leu Arg Arg Lys 
                805                 810                 815     


Leu Gln Gln Arg Gln Pro Leu Pro Asp Ser Asn Pro Glu Glu Ser Ser 
            820                 825                 830         


Val 
    


<210>  545
<211>  1020
<212>  DNA
<213>  Homosapiens

<400>  545
ctggggctgg atctgggcac agcaatttgc agggcactgc tgggcaggag tccctgatgg     60

ccaagctgct gggctctgta tctcccacaa gctgcagcgg aggccccatg gagcaggagc    120

agaagcacac gttggagaac tgaacttgaa ggacaggact tacagcattg aggtcacaca    180

gctgtcctcg ctcagccggc tcctgggcct catgaggcca tcatctctca ggcaatacct    240

ggactctgtg cccttgccac cctgccagga gcaacagcca aaggctagtg ccgagctaga    300

ccacaaggcc tgctacctgt gccacagctt gctgatgctg gccggggtag ttgttagctg    360

ccaggacatc actccagacc agtggggcga gctgcagctg ctgtgcatgc agttggaccg    420

ccacatcagc acgcagatcc gggagagccc ccaggccatg caccgcacca tgctcaagga    480

cctggctacc cagacctaca tccgttggca ggagctgctg acccactgcc agccccaggc    540

ccagtatttc agcccctgga aagacatcta aagggacagg gtcagggcag cccagggctc    600

ctggcttcag caggaagtga acaggctcag ggaactggag gaagcgaagc atcaaggcca    660

gaggaggcca catgctgacc agcctgatga ggcaagagcc tgcccctgcc accgccccga    720

cccctctcct ctctgcaaga gcctgcctct gccaccgccc cgaccccctc tcctctcagc    780

aagggatggg cctctctgcc tcgcccaccc ctcagccctc ctcccagcca tctcctcttc    840

cctaaggcct ctgtctccat agctctggtt tccctgggcc tcagtcctcc ccaccctcct    900

tcctctgtct ccctgtcact aatgtgaggt ttctttgtgc acattaaagt cttctttcag    960

caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1020


<210>  546
<211>  119
<212>  PRT
<213>  Homosapiens

<400>  546

Met Arg Pro Ser Ser Leu Arg Gln Tyr Leu Asp Ser Val Pro Leu Pro 
1               5                   10                  15      


Pro Cys Gln Glu Gln Gln Pro Lys Ala Ser Ala Glu Leu Asp His Lys 
            20                  25                  30          


Ala Cys Tyr Leu Cys His Ser Leu Leu Met Leu Ala Gly Val Val Val 
        35                  40                  45              


Ser Cys Gln Asp Ile Thr Pro Asp Gln Trp Gly Glu Leu Gln Leu Leu 
    50                  55                  60                  


Cys Met Gln Leu Asp Arg His Ile Ser Thr Gln Ile Arg Glu Ser Pro 
65                  70                  75                  80  


Gln Ala Met His Arg Thr Met Leu Lys Asp Leu Ala Thr Gln Thr Tyr 
                85                  90                  95      


Ile Arg Trp Gln Glu Leu Leu Thr His Cys Gln Pro Gln Ala Gln Tyr 
            100                 105                 110         


Phe Ser Pro Trp Lys Asp Ile 
        115                 


<210>  547
<211>  1286
<212>  DNA
<213>  Homosapiens

<400>  547
gcggcagtga cttcgccgct gctgtagttc cccggctgga tgcggtgact ggtgccagtg     60

ctcaggcgcc cgctgccctt gacctcccgc cccgcgagcc ctaactcagc gcaggaggac    120

cggctgccgc cgccgccgcc gccaggctct gatgctggtg tctggtagaa gaagattact    180

cacagctctg ctgcaggctc agaagtggcc ctttcaaccc tccagagaca tgagactagt    240

gcagttccgg gcaccccacc tggtggggcc tcacttgggc ctggagacag ggaatggtgg    300

aggggttatc aacctcaatg cctttgaccc cacactccca aagacgatga cgcagttcct    360

agagcaggga gaggccaccc tctcagtggc aagaagagcc ttggctgccc agttgccagt    420

cctaccatgg tcggaggtaa ccttcctggc tccagtcaca tggccagata aggtggtgtg    480

tgtgggcatg aattatgtgg accactgcaa agaacagaac gtgcccgtgc ccaaggagcc    540

catcatcttc agcaagtttg ccagctccat cgtggggccc tatgatgagg tggtcctccc    600

accacagagc caggaggtag attgggaagt ggagctggcc gtggtcattg gaaagaaagg    660

caagcacatc aaggccacag atgccatggc ccacgtggcc ggcttcactg tggctcatga    720

cgtgagtgct cgtgactggc taacaagacg caatgggaaa cagtggctgc tgggaaaaac    780

cttcgacacc ttctgccctc tgggccctgc cttggtgacc aaggacagtg tagcagatcc    840

acacaactta aagatctgct gccgagtgaa tggggaagtc gtccagagca gcaacaccaa    900

ccagatggta ttcaagacag aggacctgat agcctgggtc tcccagtttg ttacctttta    960

cccaggggat gtcatcctaa ctgggacccc cccaggtgtc ggtgtattca ggaaacctcc   1020

tgtctttctc aagaaggggg atgaagtcca gtgtgagatt gaagaactag gtgtcatcat   1080

caacaaggtg gtgtgatggc tcctgcacag gcccgacata ggatgagggc atctgctccc   1140

actcagccta gcccagggaa aggcccagtg gcaggtgtgg gcaggtgcca gccctgcaag   1200

ccgcctcttc tcggtagaag ggagaaggac agagctctct tcaataaatg cgtcgggtca   1260

aagcaaaaaa aaaaaaaaaa aaaaaa                                        1286


<210>  548
<211>  314
<212>  PRT
<213>  Homosapiens

<400>  548

Met Leu Val Ser Gly Arg Arg Arg Leu Leu Thr Ala Leu Leu Gln Ala 
1               5                   10                  15      


Gln Lys Trp Pro Phe Gln Pro Ser Arg Asp Met Arg Leu Val Gln Phe 
            20                  25                  30          


Arg Ala Pro His Leu Val Gly Pro His Leu Gly Leu Glu Thr Gly Asn 
        35                  40                  45              


Gly Gly Gly Val Ile Asn Leu Asn Ala Phe Asp Pro Thr Leu Pro Lys 
    50                  55                  60                  


Thr Met Thr Gln Phe Leu Glu Gln Gly Glu Ala Thr Leu Ser Val Ala 
65                  70                  75                  80  


Arg Arg Ala Leu Ala Ala Gln Leu Pro Val Leu Pro Trp Ser Glu Val 
                85                  90                  95      


Thr Phe Leu Ala Pro Val Thr Trp Pro Asp Lys Val Val Cys Val Gly 
            100                 105                 110         


Met Asn Tyr Val Asp His Cys Lys Glu Gln Asn Val Pro Val Pro Lys 
        115                 120                 125             


Glu Pro Ile Ile Phe Ser Lys Phe Ala Ser Ser Ile Val Gly Pro Tyr 
    130                 135                 140                 


Asp Glu Val Val Leu Pro Pro Gln Ser Gln Glu Val Asp Trp Glu Val 
145                 150                 155                 160 


Glu Leu Ala Val Val Ile Gly Lys Lys Gly Lys His Ile Lys Ala Thr 
                165                 170                 175     


Asp Ala Met Ala His Val Ala Gly Phe Thr Val Ala His Asp Val Ser 
            180                 185                 190         


Ala Arg Asp Trp Leu Thr Arg Arg Asn Gly Lys Gln Trp Leu Leu Gly 
        195                 200                 205             


Lys Thr Phe Asp Thr Phe Cys Pro Leu Gly Pro Ala Leu Val Thr Lys 
    210                 215                 220                 


Asp Ser Val Ala Asp Pro His Asn Leu Lys Ile Cys Cys Arg Val Asn 
225                 230                 235                 240 


Gly Glu Val Val Gln Ser Ser Asn Thr Asn Gln Met Val Phe Lys Thr 
                245                 250                 255     


Glu Asp Leu Ile Ala Trp Val Ser Gln Phe Val Thr Phe Tyr Pro Gly 
            260                 265                 270         


Asp Val Ile Leu Thr Gly Thr Pro Pro Gly Val Gly Val Phe Arg Lys 
        275                 280                 285             


Pro Pro Val Phe Leu Lys Lys Gly Asp Glu Val Gln Cys Glu Ile Glu 
    290                 295                 300                 


Glu Leu Gly Val Ile Ile Asn Lys Val Val 
305                 310                 


<210>  549
<211>  2905
<212>  DNA
<213>  Homosapiens

<400>  549
ggctaaggtg cgcgtgctcg ctggttctaa cccttctgtt gggcgtttct gctgagaggc     60

gggaggcgct gagagtctgt gcggaggtcc gtggacagac tgctttgctc gttgttgctc    120

ttcggaggcg gcgatccccg aaggcgagct gaaatacggc tgcaggctac aatttgcagc    180

cgacgattat ggaagacggc aagcgggaga ggtggcccac cctcatggag cgcttgtgct    240

cggatggctt cgcatttccc caatacccca ttaaaccgta tcatctgaag aggatccaca    300

gagctgtctt acatggtaat ctagagaaac tgaagtacct tctgctcacg tattatgacg    360

ccaataagag agacaggaag gaaaggaccg ccctacattt ggcctgtgcc actggccaac    420

cggaaatggt acatctcctg gtgtccagaa gatgtgagct taacctctgc gaccgtgaag    480

acaggacacc tctgatcaag gctgtacaac tgaggcagga ggcttgtgca actcttctgc    540

tgcaaaatgg cgccaatcca aatattacgg atttctttgg aaggactgct ctgcactacg    600

ctgtgtataa tgaagataca tccatgatag aaaaacttct ttcacatggt acaaatattg    660

aagaatgcag caagtgtgaa tatcagccac tgttatttgc tgtgagtcga agaaaagtga    720

aaatggtgga atttttatta aagaaaaaag caaatgtaaa tgccattgat tatcttggca    780

gatcagccct catacatgct gttactcttg gagaaaaaga tatagtcatt cttcttctgc    840

agcacaatat tgatgtgctt tctcgagatg cgtttcgaaa gattgcagga gattatgcca    900

ttgaggctaa gaatagagtc atttttgatc taatttatga atacgaaaga aagagatatg    960

aagatcttcc tataaatagc aatccagtgt cttctcagaa acaaccagcc ttgaaggcta   1020

caagtggcaa ggaagattct atttcaaata tagccacaga aataaaggat ggacaaaaat   1080

ctgggacagt gtcttctcag aaacaaccgg ccttgaagga tacaagtgac aaggatgatt   1140

ctgtttcgaa cacagccaca gaaataaaag atgaacaaaa atctgggaca gtgcttcctg   1200

ctgttgaaca gtgtttaaac aggagtctct acagacctga tgctgttgca cagcctgtga   1260

cagagaatga gttttctttg gaatctgaga ttatttcaaa actatacatc ccaaagagaa   1320

agattatttc tccacgatct ataaaagatg tgcttcctcc tgttgaagag gctgttgaca   1380

ggtgtctcta cctactggac cgttttgcac agcctgtgac aaaggataag tttgctttgg   1440

aatctgagaa tatttcagaa ccatacttta cgaacagaag gactatttct caacaatctg   1500

cagaaaattt agatgctgca tgtggcattg acaaaacaga aaatggaaac atgtttgaag   1560

accaaaatgt tgataaggaa ggaaaagcac taccagcaac tggacaaaaa gcaaatgtgt   1620

ctcctgagca accgccttta ttcacgaatc ttctgagcga cctcctttat ccacgcttac   1680

tctgaaagag gcagatccca gttcaaaagc agccatgaga aggaaggatt caccacctcc   1740

aggaaaagtg tcttctcaga aacaaccagc tgagaaggct acaagtgacg acaaagattc   1800

tgtttcaaat atagccacag aaataaagga gggaccaata tctgggacag tgtcttctca   1860

gaaacaacca gctgagaagg ctacaagtga cgagaaagat tctgtttcaa atatagccac   1920

agaaataaag aagggacaac aatctgggac agtgtctcct cagaaacaat cggcctggaa   1980

ggttatattt aaaaagaaag tttctctttt gaatattgcc acaagaataa tgggtggtgg   2040

gaaatctgga acagtgtctt ctcagaaaca accagcctca aaggctacaa gtgacaagac   2100

agattctgct ttgaatatag ctacagaaat aaaggatgga ctacagtgtg ggacagtgtc   2160

ttctcagaaa caaccagcct tgaaggctac aactgacgag gaagactctg tttcgaatat   2220

agccacagaa ataaaggatg gagaaaaatc tgggacagtg tcttctcaga aacaaccagc   2280

cttgaaggct acaactgatg agaaagattc tgtttcgaac atagccacag aaataaagga   2340

tggagaaaaa tctgggacag tgtcttctca gaaaccacca gccttgacgg ctacaagtga   2400

cgaggaaggt tctgttttga gtatagccag agaaaacaag gatggagaaa aatctaggac   2460

agtgtcttct cggaaaaaac cagccttgaa ggctacaagt gatgagaagg attctttttc   2520

gaatataacc agaggaaaaa aggatggaga aatatctagg aaagtgtctt ctcagaaacc   2580

accaaccttg aagtgtcttc tgagaaacca ccaggcttga agtgtcttct cggaaaaaac   2640

catccttgga ggccacaagt gatgagaagg attctttttc gaatataacc agagaaaaaa   2700

aggatggaga aatatctagg aaagtgtctt ctcagaaacc accagccttg aagggtacaa   2760

gtgacgagga agattctgtt ttgggtatag ccagagaaaa caaggatgga gaaaaatcta   2820

ggacagtgtc ttctgagaaa ccaccaggct tgaaggctac aagtgatgag aaagattctg   2880

ttttgaatat agccagagga aaaaa                                         2905


<210>  550
<211>  498
<212>  PRT
<213>  Homosapiens

<400>  550

Met Glu Asp Gly Lys Arg Glu Arg Trp Pro Thr Leu Met Glu Arg Leu 
1               5                   10                  15      


Cys Ser Asp Gly Phe Ala Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His 
            20                  25                  30          


Leu Lys Arg Ile His Arg Ala Val Leu His Gly Asn Leu Glu Lys Leu 
        35                  40                  45              


Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys 
    50                  55                  60                  


Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met 
65                  70                  75                  80  


Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg 
                85                  90                  95      


Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala 
            100                 105                 110         


Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asn Pro Asn Ile Thr Asp 
        115                 120                 125             


Phe Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr 
    130                 135                 140                 


Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn Ile Glu Glu Cys 
145                 150                 155                 160 


Ser Lys Cys Glu Tyr Gln Pro Leu Leu Phe Ala Val Ser Arg Arg Lys 
                165                 170                 175     


Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Val Asn Ala 
            180                 185                 190         


Ile Asp Tyr Leu Gly Arg Ser Ala Leu Ile His Ala Val Thr Leu Gly 
        195                 200                 205             


Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn Ile Asp Val Leu 
    210                 215                 220                 


Ser Arg Asp Ala Phe Arg Lys Ile Ala Gly Asp Tyr Ala Ile Glu Ala 
225                 230                 235                 240 


Lys Asn Arg Val Ile Phe Asp Leu Ile Tyr Glu Tyr Glu Arg Lys Arg 
                245                 250                 255     


Tyr Glu Asp Leu Pro Ile Asn Ser Asn Pro Val Ser Ser Gln Lys Gln 
            260                 265                 270         


Pro Ala Leu Lys Ala Thr Ser Gly Lys Glu Asp Ser Ile Ser Asn Ile 
        275                 280                 285             


Ala Thr Glu Ile Lys Asp Gly Gln Lys Ser Gly Thr Val Ser Ser Gln 
    290                 295                 300                 


Lys Gln Pro Ala Leu Lys Asp Thr Ser Asp Lys Asp Asp Ser Val Ser 
305                 310                 315                 320 


Asn Thr Ala Thr Glu Ile Lys Asp Glu Gln Lys Ser Gly Thr Val Leu 
                325                 330                 335     


Pro Ala Val Glu Gln Cys Leu Asn Arg Ser Leu Tyr Arg Pro Asp Ala 
            340                 345                 350         


Val Ala Gln Pro Val Thr Glu Asn Glu Phe Ser Leu Glu Ser Glu Ile 
        355                 360                 365             


Ile Ser Lys Leu Tyr Ile Pro Lys Arg Lys Ile Ile Ser Pro Arg Ser 
    370                 375                 380                 


Ile Lys Asp Val Leu Pro Pro Val Glu Glu Ala Val Asp Arg Cys Leu 
385                 390                 395                 400 


Tyr Leu Leu Asp Arg Phe Ala Gln Pro Val Thr Lys Asp Lys Phe Ala 
                405                 410                 415     


Leu Glu Ser Glu Asn Ile Ser Glu Pro Tyr Phe Thr Asn Arg Arg Thr 
            420                 425                 430         


Ile Ser Gln Gln Ser Ala Glu Asn Leu Asp Ala Ala Cys Gly Ile Asp 
        435                 440                 445             


Lys Thr Glu Asn Gly Asn Met Phe Glu Asp Gln Asn Val Asp Lys Glu 
    450                 455                 460                 


Gly Lys Ala Leu Pro Ala Thr Gly Gln Lys Ala Asn Val Ser Pro Glu 
465                 470                 475                 480 


Gln Pro Pro Leu Phe Thr Asn Leu Leu Ser Asp Leu Leu Tyr Pro Arg 
                485                 490                 495     


Leu Leu 
        


<210>  551
<211>  2418
<212>  DNA
<213>  Homosapiens

<400>  551
gtgcagaaag caccgtcttt tactagaaga agacaataaa atgttggtca atgaactgaa     60

tcattcgaaa gaaaaagaat gccaatatga aaaagagaaa gcagaaagag aagtagctgt    120

gagacagctt caacaaaaac gagatgatgt cttaaacaaa ggatcagcaa caaaagctct    180

gctggatgct tcatcgcgtc actgcaccta tttagaaaat gggatgcagg attcaaggaa    240

gaaattagac cagatgagaa gtcaatttca agaaatacag gatcaactta cagctactat    300

aagatgtact aaggagatgg atggcgacac acaaaagctt gaagtagaac atgtgatgat    360

gagaaaaatt attaaaaaac aggatgacca aattgagcgg cttgagaaaa tcctgcagca    420

ttcaagtttg atgctgcagg tgtttgagag ctagatgaag atatggacat ttctggaatt    480

aagagccccc tctacattga gcacaagaca gtgacgaatc cacattcttc agccagaaag    540

tcacctctga gagccaaatg tctgactata gaaaggagag tcaaagaatg ataacgacat    600

ctcaggaaaa ttgtgaaaat aatcagcagc cggatgtgga taaccctttc aaatttctcc    660

tggggcctcc aaccaccccc actggtgttc tcctgctgac agtgatttca attttttctg    720

ggctggagct ccctgatgga ggggcaggcc accatctttg ctgtttttgc aacttagcca    780

cttcagcctt cagtctttgg agtgtccaag gagaccaggg ggtgatgtgg accctcagca    840

tagcacagct gctctataaa gatgaggcca gactgctttt ttgagcactt tcccaatgcc    900

attcctcctc actgggcaaa acctccaaac tggggtctcc agccacctcc tacaggtgtg    960

tttgggccag caacaagttc attcatacct ccctagggca aagcttccaa agggagcggt   1020

aggctgccat ctttgctgtt tcacaggctt cactgatgat aactccaggt actggaaaat   1080

ctgaggctac tagagactgg agcgggccct gggcatactg cagcagccct atggaaaagt   1140

ggccagactg ttacctgggt tcccattcct atatcttctc actaggcaag tcttgcaggc   1200

ctgggcctct acctaacccc ccctaccaga actgttgagc cagtagcaac tcagccactc   1260

cctggagaga gcctccaggg gcaactgaaa gcctctctgc cactgcttct gcagtggaac   1320

tgtccttgct accctcagac tgatgaagga gctaacaccc ttatctacac cttcaacaag   1380

ctttaattga ccaaagccca tctctcatgg gttctacaca ctccccactg ctcatgacag   1440

ggaacccctg gattggcccc cacagcacga attctccatc ctgattgctg attgcagtaa   1500

acagttgctg tattctccag gggtggtgga actctgagga gacaaacaaa agacccttgg   1560

ctacaaccac tactaatgtc ccttcctctt ctgcctcaaa gttaggaaag aaatataaac   1620

actgagattg ccccagagct gcagtgggca gcctaggagt gccaagccat gacctacagc   1680

cagcactcaa gggggagaga agcacatttt cagatcattg agagggaaca tggctgcaac   1740

tgtaaggaaa cataggggag ccacatgacc aagcaagagt ctaccaactg accagtaagc   1800

ccaagtgcca cctactggat cacatcccaa agcttcagca tcaaaaatac cctactaata   1860

tactcccctc tgaaaccaga aatgagaagt cagcttcaaa taaagaccct gcacaaagcc   1920

tcagcctggt gaaaacatcc gaaaataagt ctacggactg tactcaatct acactgcaat   1980

taaaggaaaa cccataggtg gaaatgagaa gaaaccaatg caagaactcc agtaactcaa   2040

atggcctctg tgtcatatgt ccttctaaca accacaccag ttctccaaca agagttctta   2100

acctggatga actgtctgga attacataaa tataattcag aatatggata ggaaaaaaaa   2160

tcatcaagac tcaggagaat ggcaaaaccc aatccaagga aaataagaat aacagtaaag   2220

tgttacagga gctgaaggat aaagtagctg gtataataaa aaagaaccta accgatctga   2280

aagcgccgaa gaacacaata caagaattcc acaatgcaat cacaagtatt aacagcagaa   2340

aaaaaaacct gaggaacgaa tctcagaact tgaagattgg ttctctaaaa taagatggac   2400

aaaaaaaaaa aaaaaaaa                                                 2418


<210>  552
<211>  137
<212>  PRT
<213>  Homosapiens

<400>  552

Met Leu Val Asn Glu Leu Asn His Ser Lys Glu Lys Glu Cys Gln Tyr 
1               5                   10                  15      


Glu Lys Glu Lys Ala Glu Arg Glu Val Ala Val Arg Gln Leu Gln Gln 
            20                  25                  30          


Lys Arg Asp Asp Val Leu Asn Lys Gly Ser Ala Thr Lys Ala Leu Leu 
        35                  40                  45              


Asp Ala Ser Ser Arg His Cys Thr Tyr Leu Glu Asn Gly Met Gln Asp 
    50                  55                  60                  


Ser Arg Lys Lys Leu Asp Gln Met Arg Ser Gln Phe Gln Glu Ile Gln 
65                  70                  75                  80  


Asp Gln Leu Thr Ala Thr Ile Arg Cys Thr Lys Glu Met Asp Gly Asp 
                85                  90                  95      


Thr Gln Lys Leu Glu Val Glu His Val Met Met Arg Lys Ile Ile Lys 
            100                 105                 110         


Lys Gln Asp Asp Gln Ile Glu Arg Leu Glu Lys Ile Leu Gln His Ser 
        115                 120                 125             


Ser Leu Met Leu Gln Val Phe Glu Ser 
    130                 135         


<210>  553
<211>  523
<212>  DNA
<213>  Homosapiens

<400>  553
cggaagtttt gctgctagtc gcggacgcaa tggcttcaag gttacttcgc ggagctggaa     60

cgctggccgc gcaggccctg agggctcgcg gccccagtgg cgcggccgcg atgcgctcca    120

tggcatctgg aggtggtgtt cccactgatg aagagcaggc gactgggttg gagagggaga    180

tcatgctggc tgcaaagaag ggactggacc catacaatgt actggcccca aagggagctt    240

caggcaccag ggaagaccct aatttagtcc cctccatctc caacaagaga atagtaggct    300

gcatctgtga agaggacaat accagcgtcg tctggttttg gctgcacaaa ggcgaggccc    360

agcgatgccc ccgctgtgga gcccattaca agctggtgcc ccagcagctg gcacactgag    420

cacctgcact aaattactca aaatgtgctg taaagtttct tctttccagt aaagactagc    480

cattgcattg gctccttctc ccataaaaaa aaaaaaaaaa aaa                      523


<210>  554
<211>  129
<212>  PRT
<213>  Homosapiens

<400>  554

Met Ala Ser Arg Leu Leu Arg Gly Ala Gly Thr Leu Ala Ala Gln Ala 
1               5                   10                  15      


Leu Arg Ala Arg Gly Pro Ser Gly Ala Ala Ala Met Arg Ser Met Ala 
            20                  25                  30          


Ser Gly Gly Gly Val Pro Thr Asp Glu Glu Gln Ala Thr Gly Leu Glu 
        35                  40                  45              


Arg Glu Ile Met Leu Ala Ala Lys Lys Gly Leu Asp Pro Tyr Asn Val 
    50                  55                  60                  


Leu Ala Pro Lys Gly Ala Ser Gly Thr Arg Glu Asp Pro Asn Leu Val 
65                  70                  75                  80  


Pro Ser Ile Ser Asn Lys Arg Ile Val Gly Cys Ile Cys Glu Glu Asp 
                85                  90                  95      


Asn Thr Ser Val Val Trp Phe Trp Leu His Lys Gly Glu Ala Gln Arg 
            100                 105                 110         


Cys Pro Arg Cys Gly Ala His Tyr Lys Leu Val Pro Gln Gln Leu Ala 
        115                 120                 125             


His 
    


<210>  555
<211>  2054
<212>  DNA
<213>  Homosapiens

<400>  555
gcctgctggg caggccggcg cggcccggcc atggagtcct acgacatcat cgccaaccag     60

cctgtggtca tcgacaacgg ttcgggggtg attaaagctg gctttgcagg agaccagatt    120

cccaaatact gtttcccaaa ctatgtcggg cggccgaagc acatgcgggt gatggctgga    180

gccctggagg gggacctctt catcggacca aaagcagagg agcaccgggg gctgctgacc    240

atccgctacc ccatggagca cggcgtggtg cgagactgga acgacatgga acgcatctgg    300

cagtacgtct actccaagga tcagctgcag accttctcgg aggagcatcc tgtgctcctc    360

acggaggccc cgctcaaccc gagtaagaac cgggagaagg cggcagaggt gttctttgag    420

accttcaacg tgccggccct gttcatctcc atgcaggctg tgctcagtct gtacgcaaca    480

ggacgcacga caggagtggt tctagactca ggggacgggg tcactcatgc tgtgcccatc    540

tatgagggct ttgccatgcc tcactccatc atgcgggtgg acattgccgg ccgcgacgtc    600

tcccgctacc tccgactcct gctgcgcaag gaaggggttg acttccatac ctcggctgag    660

tttgaggttg tccggacaat caaagagcga gcgtgctacc tgtccatcaa cccacagaag    720

gatgaggctc tggagacgga gaaggtgcag tacacgttgc cagacggcag cacgcttgat    780

gtggggcctg cacgattccg ggcccccgag ctgctgttcc agccggacct tgtcggggat    840

gagagtgagg ggctccatga ggtggtggcc ttcgccatac acaagtccga catggacctg    900

cgccggacgc tgttcgccaa catcgtgctc tcaggtggct caacgctttt caaaggcttc    960

ggagaccgat tactcagtga agtgaagaag cttgccccaa aggatatcaa aatcaagatc   1020

tcagccccgc aggaacggct gtactccaca tggattggcg gctccatcct ggcctcgctg   1080

gacactttta agaagatgtg ggtgtccaaa aaggagtatg aagaggatgg ctcccgtgct   1140

attcatcgca aaactttcta gtgcccaagg agggcggggc atgttgggag agggggaggg   1200

aggggagaca gagcctttaa ccctttttgg tcttggctcg tatactaggc ttagggtccc   1260

ctgcatgccc tgaacccctg ggtgggtggc acagcagtgc ccccctgcag ccttcccctc   1320

tacacaggac atgcacacac aagtaacatt gagctgcatg gacaggagcc ttgagctggc   1380

gtgtgggaat tgagcgccat gtcaggctgt tgtgggtatc cccctggcag ggccagctag   1440

gcctgtggtt cccctgctcc gactctcagg gctgcctccc tgagctccag ggccagaatg   1500

cctggatgcc tgggtagcca gtttggggag tgggctgcaa ggggcagcca gcagcgccca   1560

ctggtgtgtc actgcatcca ttgccacctc ctgttcgtga cctgacaggg tgacacagcc   1620

cctttcacac tctgtcctcc tatcttcctg ggtagatgcc ctggtgtagg gctgagtact   1680

gaatggtctt ccatccccag caagggggtg cagcccaggg tcaggccctt cagagccagg   1740

gctagaggat gcacggtggc tagagccagc tgcactatcc ttttcagagc acttcatcca   1800

cttgctcctc cctctaccct cggcaccctg ggtgggaaag ggttgatgct catcatttat   1860

tgaggggaag ccacttaata aggagtcaga cctaaaaggg ggtgggggac attttcttac   1920

ctcacccaag aaagaggtcg tcacttttgc tgtggccagg gccccacctc cctctctcag   1980

atatgtacaa taatttaaca cggttgcctg aaaaaaactt ttgtaaatca ttatagtaat   2040

aattatggac aagg                                                     2054


<210>  556
<211>  376
<212>  PRT
<213>  Homosapiens

<400>  556

Met Glu Ser Tyr Asp Ile Ile Ala Asn Gln Pro Val Val Ile Asp Asn 
1               5                   10                  15      


Gly Ser Gly Val Ile Lys Ala Gly Phe Ala Gly Asp Gln Ile Pro Lys 
            20                  25                  30          


Tyr Cys Phe Pro Asn Tyr Val Gly Arg Pro Lys His Met Arg Val Met 
        35                  40                  45              


Ala Gly Ala Leu Glu Gly Asp Leu Phe Ile Gly Pro Lys Ala Glu Glu 
    50                  55                  60                  


His Arg Gly Leu Leu Thr Ile Arg Tyr Pro Met Glu His Gly Val Val 
65                  70                  75                  80  


Arg Asp Trp Asn Asp Met Glu Arg Ile Trp Gln Tyr Val Tyr Ser Lys 
                85                  90                  95      


Asp Gln Leu Gln Thr Phe Ser Glu Glu His Pro Val Leu Leu Thr Glu 
            100                 105                 110         


Ala Pro Leu Asn Pro Ser Lys Asn Arg Glu Lys Ala Ala Glu Val Phe 
        115                 120                 125             


Phe Glu Thr Phe Asn Val Pro Ala Leu Phe Ile Ser Met Gln Ala Val 
    130                 135                 140                 


Leu Ser Leu Tyr Ala Thr Gly Arg Thr Thr Gly Val Val Leu Asp Ser 
145                 150                 155                 160 


Gly Asp Gly Val Thr His Ala Val Pro Ile Tyr Glu Gly Phe Ala Met 
                165                 170                 175     


Pro His Ser Ile Met Arg Val Asp Ile Ala Gly Arg Asp Val Ser Arg 
            180                 185                 190         


Tyr Leu Arg Leu Leu Leu Arg Lys Glu Gly Val Asp Phe His Thr Ser 
        195                 200                 205             


Ala Glu Phe Glu Val Val Arg Thr Ile Lys Glu Arg Ala Cys Tyr Leu 
    210                 215                 220                 


Ser Ile Asn Pro Gln Lys Asp Glu Ala Leu Glu Thr Glu Lys Val Gln 
225                 230                 235                 240 


Tyr Thr Leu Pro Asp Gly Ser Thr Leu Asp Val Gly Pro Ala Arg Phe 
                245                 250                 255     


Arg Ala Pro Glu Leu Leu Phe Gln Pro Asp Leu Val Gly Asp Glu Ser 
            260                 265                 270         


Glu Gly Leu His Glu Val Val Ala Phe Ala Ile His Lys Ser Asp Met 
        275                 280                 285             


Asp Leu Arg Arg Thr Leu Phe Ala Asn Ile Val Leu Ser Gly Gly Ser 
    290                 295                 300                 


Thr Leu Phe Lys Gly Phe Gly Asp Arg Leu Leu Ser Glu Val Lys Lys 
305                 310                 315                 320 


Leu Ala Pro Lys Asp Ile Lys Ile Lys Ile Ser Ala Pro Gln Glu Arg 
                325                 330                 335     


Leu Tyr Ser Thr Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Asp Thr 
            340                 345                 350         


Phe Lys Lys Met Trp Val Ser Lys Lys Glu Tyr Glu Glu Asp Gly Ser 
        355                 360                 365             


Arg Ala Ile His Arg Lys Thr Phe 
    370                 375     


<210>  557
<211>  2450
<212>  DNA
<213>  Homosapiens

<400>  557
aataggttag tttcagacaa gcctgcttgc cggagctcag cagacaccag gccttccggg     60

caggcctggc ccaccgtggg cctcagagct gctgctgggg cattcagaac cggctctcca    120

ttggcattgg gaccagagac cccgcaagtg gcctgtttgc ctggacatcc acctgtacgt    180

ccccaggttt cgggaggccc aggggcgatg ccagaccccg cggcgcacct gcccttcttc    240

tacggcagca tctcgcgtgc cgaggccgag gagcacctga agctggcggg catggcggac    300

gggctcttcc tgctgcgcca gtgcctgcgc tcgctgggcg gctatgtgct gtcgctcgtg    360

cacgatgtgc gcttccacca ctttcccatc gagcgccagc tcaacggcac ctacgccatt    420

gccggcggca aagcgcactg tggaccggca gagctctgcg agttctactc gcgcgacccc    480

gacgggctgc cctgcaacct gcgcaagccg tgcaaccggc cgtcgggcct cgagccgcag    540

ccgggggtct tcgactgcct gcgagacgcc atggtgcgtg actacgtgcg ccagacgtgg    600

aagctggagg gcgaggccct ggagcaggcc atcatcagcc aggccccgca ggtggagaag    660

ctcattgcta cgacggccca cgagcggatg ccctggtacc acagcagcct gacgcgtgag    720

gaggccgagc gcaaacttta ctctggggcg cagaccgacg gcaagttcct gctgaggccg    780

cggaaggagc agggcacata cgccctgtcc ctcatctatg ggaagacggt gtaccactac    840

ctcatcagcc aagacaaggc gggcaagtac tgcattcccg agggcaccaa gtttgacacg    900

ctctggcagc tggtggagta tctgaagctg aaggcggacg ggctcatcta ctgcctgaag    960

gaggcctgcc ccaacagcag tgccagcaac gcctcagggg ctgctgctcc cacactccca   1020

gcccacccat ccacgttgac tcatcctcag agacgaatcg acaccctcaa ctcagatgga   1080

tacacccctg agccagcacg cataacgtcc ccagacaaac cgcggccgat gcccatggac   1140

acgagcgtgt atgagagccc ctacagcgac ccagaggagc tcaaggacaa gaagctcttc   1200

ctgaagcgcg ataacctcct catagctgac attgaacttg gctgcggcaa ctttggctca   1260

gtgcgccagg gcgtgtaccg catgcgcaag aagcagatcg acgtggccat caaggtgctg   1320

aagcagggca cggagaaggc agacacggaa gagatgatgc gcgaggcgca gatcatgcac   1380

cagctggaca acccctacat cgtgcggctc attggcgtct gccaggccga ggccctcatg   1440

ctggtcatgg agatggctgg gggcgggccg ctgcacaagt tcctggtcgg caagagggag   1500

gagatccctg tgagcaatgt ggccgagctg ctgcaccagg tgtccatggg gatgaagtac   1560

ctggaggaga agaactttgt gcaccgtgac ctggcggccc gcaacgtcct gctggttaac   1620

cggcactacg ccaagatcag cgactttggc ctctccaaag cactgggtgc cgacgacagc   1680

tactacactg cccgctcagc agggaagtgg ccgctcaagt ggtacgcacc cgaatgcatc   1740

aacttccgca agttctccag ccgcagcgat gtctggagct atggggtcac catgtgggag   1800

gccttgtcct acggccagaa gccctacaag aagatgaaag ggccggaggt catggccttc   1860

atcgagcagg gcaagcggat ggagtgccca ccagagtgtc cacccgaact gtacgcactc   1920

atgagtgact gctggatcta caagtgggag gatcgccccg acttcctgac cgtggagcag   1980

cgcatgcgag cctgttacta cagcctggcc agcaaggtgg aagggccccc aggcagcaca   2040

cagaaggctg aggctgcctg tgcctgagct cccgctgccc aggggagccc tccacgccgg   2100

ctcttcccca ccctcagccc caccccaggt cctgcagtct ggctgagccc tgcttggttg   2160

tctccacaca cagctgggct gtggtagggg gtgtctcagg ccacaccggc cttgcattgc   2220

ctgcctggcc ccctgtcctc tctggctggg gagcagggag gtccgggagg gtgcggctgt   2280

gcagcctgtc ctgggctggt ggctcccgga gggccctgag ctgagggcat tgcttacacg   2340

gatgccttcc cctgggccct gacattggag cctgggcatc ctcaggtggt caggcgtaga   2400

tcaccagaat aaacccagct tccctcttga aaaaaaaaaa aaaaaaaaaa              2450


<210>  558
<211>  619
<212>  PRT
<213>  Homosapiens

<400>  558

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  559
<211>  1468
<212>  DNA
<213>  Homosapiens

<400>  559
tgcatgctcc agggacggca cccttgtctg gggcaggtgc ttgtgggggc tgaggctgcc     60

ttgctcccca cacccctgcc cctgacctgg gagtgtaccg ctgtgtgtgc ccagcacgca    120

taacgtcccc agacaaaccg cggccgatgc ccatggacac gagcgtgtat gagagcccct    180

acagcgaccc agaggagctc aaggacaaga agctcttcct gaagcgcgat aacctcctca    240

tagctgacat tgaacttggc tgcggcaact ttggctcagt gcgccagggc gtgtaccgca    300

tgcgcaagaa gcagatcgac gtggccatca aggtgctgaa gcagggcacg gagaaggcag    360

acacggaaga gatgatgcgc gaggcgcaga tcatgcacca gctggacaac ccctacatcg    420

tgcggctcat tggcgtctgc caggccgagg ccctcatgct ggtcatggag atggctgggg    480

gcgggccgct gcacaagttc ctggtcggca agagggagga gatccctgtg agcaatgtgg    540

ccgagctgct gcaccaggtg tccatgggga tgaagtacct ggaggagaag aactttgtgc    600

accgtgacct ggcggcccgc aacgtcctgc tggttaaccg gcactacgcc aagatcagcg    660

actttggcct ctccaaagca ctgggtgccg acgacagcta ctacactgcc cgctcagcag    720

ggaagtggcc gctcaagtgg tacgcacccg aatgcatcaa cttccgcaag ttctccagcc    780

gcagcgatgt ctggagctat ggggtcacca tgtgggaggc cttgtcctac ggccagaagc    840

cctacaagaa gatgaaaggg ccggaggtca tggccttcat cgagcagggc aagcggatgg    900

agtgcccacc agagtgtcca cccgaactgt acgcactcat gagtgactgc tggatctaca    960

agtgggagga tcgccccgac ttcctgaccg tggagcagcg catgcgagcc tgttactaca   1020

gcctggccag caaggtggaa gggcccccag gcagcacaca gaaggctgag gctgcctgtg   1080

cctgagctcc cgctgcccag gggagccctc cacgccggct cttccccacc ctcagcccca   1140

ccccaggtcc tgcagtctgg ctgagccctg cttggttgtc tccacacaca gctgggctgt   1200

ggtagggggt gtctcaggcc acaccggcct tgcattgcct gcctggcccc ctgtcctctc   1260

tggctgggga gcagggaggt ccgggagggt gcggctgtgc agcctgtcct gggctggtgg   1320

ctcccggagg gccctgagct gagggcattg cttacacgga tgccttcccc tgggccctga   1380

cattggagcc tgggcatcct caggtggtca ggcgtagatc accagaataa acccagcttc   1440

cctcttgaaa aaaaaaaaaa aaaaaaaa                                      1468


<210>  560
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  560

Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser Asp Pro Glu 
1               5                   10                  15      


Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn Leu Leu Ile 
            20                  25                  30          


Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val Arg Gln Gly 
        35                  40                  45              


Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile Lys Val Leu 
    50                  55                  60                  


Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met Arg Glu Ala 
65                  70                  75                  80  


Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg Leu Ile Gly 
                85                  90                  95      


Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met Ala Gly Gly 
            100                 105                 110         


Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu Ile Pro Val 
        115                 120                 125             


Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly Met Lys Tyr 
    130                 135                 140                 


Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
145                 150                 155                 160 


Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe Gly Leu Ser 
                165                 170                 175     


Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg Ser Ala Gly 
            180                 185                 190         


Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn Phe Arg Lys 
        195                 200                 205             


Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr Met Trp Glu 
    210                 215                 220                 


Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys Gly Pro Glu 
225                 230                 235                 240 


Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys Pro Pro Glu 
                245                 250                 255     


Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp Ile Tyr Lys 
            260                 265                 270         


Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg Met Arg Ala 
        275                 280                 285             


Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro Gly Ser Thr 
    290                 295                 300                 


Gln Lys Ala Glu Ala Ala Cys Ala 
305                 310         


<210>  561
<211>  2132
<212>  DNA
<213>  Homosapiens

<400>  561
ggcggggctc tcggggccgc tgccgccgcc gccgccgcgc attgtgcagc aggcgggccc     60

ccgcgcggca gggccctgga cccgcgcggc tcccggggat ggtgagcaag gcgctgctgc    120

gcctcgtgtc tgccgtcaac cgcaggagga tgaagctgct gctgggcatc gccttgctgg    180

cctacgtcgc ctctgtttgg ggcaacttcg ttaatatgag gtctatccag gaaaatggtg    240

aactaaaaat tgaaagcaag attgaagaga tggttgaacc actaagagag aaaatcagag    300

atttagaaaa aagctttacc cagaaatacc caccagtaaa gtttttatca gaaaaggatc    360

ggaaaagaat tttgataaca ggaggcgcag ggttcgtggg ctcccatcta actgacaaac    420

tcatgatgga cggccacgag gtgaccgtgg tggacaattt cttcacgggc aggaagagaa    480

acgtggagca ctggatcgga catgagaact tcgagttgat taaccacgac gtggtggagc    540

ccctctacat cgaggttgac cagatatacc atctggcatc tccagcctcc cctccaaact    600

acatgtataa tcctatcaag acattaaaga ccaatacgat tgggacatta aacatgttgg    660

ggctggcaaa acgagtcggt gcccgtctgc tcctggcctc cacatcggag gtgtatggag    720

atcctgaagt ccaccctcaa agtgaggatt actggggcca cgtgaatcca ataggacctc    780

gggcctgcta cgatgaaggc aaacgtgttg cagagaccat gtgctatgcc tacatgaagc    840

aggaaggcgt ggaagtgcga gtggccagaa tcttcaacac ctttgggcca cgcatgcaca    900

tgaacgatgg gcgagtagtc agcaacttca tcctgcaggc gctccagggg gagccactca    960

cggtatacgg atccgggtct cagacaaggg cgttccagta cgtcagcgat ctagtgaatg   1020

gcctcgtggc tctcatgaac agcaacgtca gcagcccggt caacctgggg aacccagaag   1080

aacacacaat cctagaattt gctcagttaa ttaaaaacct tgttggtagc ggaagtgaaa   1140

ttcagtttct ctccgaagcc caggatgacc cacagaaaag aaaaccagac atcaaaaaag   1200

caaagctgat gctggggtgg gagcccgtgg tcccgctgga ggaaggttta aacaaagcaa   1260

ttcactactt ccgtaaagaa ctcgagtacc aggcaaataa tcagtacatc cccaaaccaa   1320

agcctgccag aataaagaaa ggacggactc gccacagctg aactcctcac ttttaggaca   1380

caagactacc attgtacact tgatgggatg tatttttggc ttttttttgt tgtcgtttaa   1440

agaaagactt taacaggtgt catgaagaac aaactggaat ttcattctga agcttgcttt   1500

aatgaaatgg atgtgcctaa aagctcccct caaaaaactg cagattttgc cttgcacttt   1560

ttgaatctct ctttttatgt aaaatagcgt agatgcatct ctgcgtattt tcaagttttt   1620

ttatcttgct gtgagagcat atgttgtgac tgtcgttgac agttttattt actggtttct   1680

ttgtgaagct gaaaaggaac attaagcggg acaaaaaatg ccgattttat ttataaaagt   1740

gggtacttaa taaatgagtc gttatactat gcataaagaa aaatcctagc agtattgtca   1800

ggtggtggtg cgccggcatt gattttaggg cagataaaag aattctgtgt gagagcttta   1860

tgtttctctt ttaattcaga gtttttccaa ggtctacttt tgagttgcaa acttgacttt   1920

gaaatattcc tgttggtcat gatcaaggat atttgaaatc actactgtgt tttgctgcgt   1980

atctggggcg ggggcaggtt ggggggcaca aagttaacat attcttggtt aaccatggtt   2040

aaatatgcta ttttaataaa atattgaaac tcaccagtca tggaaaaaaa aaaaaaaaaa   2100

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                 2132


<210>  562
<211>  420
<212>  PRT
<213>  Homosapiens

<400>  562

Met Val Ser Lys Ala Leu Leu Arg Leu Val Ser Ala Val Asn Arg Arg 
1               5                   10                  15      


Arg Met Lys Leu Leu Leu Gly Ile Ala Leu Leu Ala Tyr Val Ala Ser 
            20                  25                  30          


Val Trp Gly Asn Phe Val Asn Met Arg Ser Ile Gln Glu Asn Gly Glu 
        35                  40                  45              


Leu Lys Ile Glu Ser Lys Ile Glu Glu Met Val Glu Pro Leu Arg Glu 
    50                  55                  60                  


Lys Ile Arg Asp Leu Glu Lys Ser Phe Thr Gln Lys Tyr Pro Pro Val 
65                  70                  75                  80  


Lys Phe Leu Ser Glu Lys Asp Arg Lys Arg Ile Leu Ile Thr Gly Gly 
                85                  90                  95      


Ala Gly Phe Val Gly Ser His Leu Thr Asp Lys Leu Met Met Asp Gly 
            100                 105                 110         


His Glu Val Thr Val Val Asp Asn Phe Phe Thr Gly Arg Lys Arg Asn 
        115                 120                 125             


Val Glu His Trp Ile Gly His Glu Asn Phe Glu Leu Ile Asn His Asp 
    130                 135                 140                 


Val Val Glu Pro Leu Tyr Ile Glu Val Asp Gln Ile Tyr His Leu Ala 
145                 150                 155                 160 


Ser Pro Ala Ser Pro Pro Asn Tyr Met Tyr Asn Pro Ile Lys Thr Leu 
                165                 170                 175     


Lys Thr Asn Thr Ile Gly Thr Leu Asn Met Leu Gly Leu Ala Lys Arg 
            180                 185                 190         


Val Gly Ala Arg Leu Leu Leu Ala Ser Thr Ser Glu Val Tyr Gly Asp 
        195                 200                 205             


Pro Glu Val His Pro Gln Ser Glu Asp Tyr Trp Gly His Val Asn Pro 
    210                 215                 220                 


Ile Gly Pro Arg Ala Cys Tyr Asp Glu Gly Lys Arg Val Ala Glu Thr 
225                 230                 235                 240 


Met Cys Tyr Ala Tyr Met Lys Gln Glu Gly Val Glu Val Arg Val Ala 
                245                 250                 255     


Arg Ile Phe Asn Thr Phe Gly Pro Arg Met His Met Asn Asp Gly Arg 
            260                 265                 270         


Val Val Ser Asn Phe Ile Leu Gln Ala Leu Gln Gly Glu Pro Leu Thr 
        275                 280                 285             


Val Tyr Gly Ser Gly Ser Gln Thr Arg Ala Phe Gln Tyr Val Ser Asp 
    290                 295                 300                 


Leu Val Asn Gly Leu Val Ala Leu Met Asn Ser Asn Val Ser Ser Pro 
305                 310                 315                 320 


Val Asn Leu Gly Asn Pro Glu Glu His Thr Ile Leu Glu Phe Ala Gln 
                325                 330                 335     


Leu Ile Lys Asn Leu Val Gly Ser Gly Ser Glu Ile Gln Phe Leu Ser 
            340                 345                 350         


Glu Ala Gln Asp Asp Pro Gln Lys Arg Lys Pro Asp Ile Lys Lys Ala 
        355                 360                 365             


Lys Leu Met Leu Gly Trp Glu Pro Val Val Pro Leu Glu Glu Gly Leu 
    370                 375                 380                 


Asn Lys Ala Ile His Tyr Phe Arg Lys Glu Leu Glu Tyr Gln Ala Asn 
385                 390                 395                 400 


Asn Gln Tyr Ile Pro Lys Pro Lys Pro Ala Arg Ile Lys Lys Gly Arg 
                405                 410                 415     


Thr Arg His Ser 
            420 


<210>  563
<211>  945
<212>  DNA
<213>  Homosapiens

<400>  563
atggctttct ctgctcgcgc gcagtgtggc ggcagcaggt gcggctttga gatgcagaat     60

gacactggtg agttcatagg cctgtacatg ccatggaaat ggtccaatag caactgcatc    120

atcgatgcca aggaccacaa atccatccag atgaacgggg ccaaggttga caaggtagca    180

ggcaggttta accaccagtt taaaacctat gctatctgca gggccattcg caggatggcc    240

tttgtcaagc tgttctttgt ccctatccgt ggcttttcct tgacctctgc cctggcatgc    300

acccaacaga gccccttctc tttgatcact tcttccgtgg taacagtgaa cagaattctg    360

ctgggagcca cagaatgttt actgaagatt tatgggtcac cggagaaaac ggggagcgat    420

aggaacctgc agacgcggac ccacgcgtcc cgacgtgggc agacctatgt actttatgat    480

gctgctctgg caacgccctc cctccaccca aaggcggccg agagcctgac catgcacctg    540

gccgacggtg ctgctccacc gagcgctgaa ctcgctgtct ccctgaagca cgctccccgt    600

ctggctgacc ttgcaggacc gtttgttcaa accactccca ggaacttcct gcccaggccc    660

cgcactcttc acccgaactt ccgtgactcc tcagggcacc gtcgcttagg ggtccgtttt    720

tgccaattca ctgtgtcttt actgcattct gctgggtgct gccagcatgt ggaaggctgt    780

gataggagca gcacttgccc ccggggcggc ctggtggtcc tcccctgctg ggcagagcag    840

ccccatgaga tcagcagcaa tgttcaatcc cgaggagtca cagagttgcc tatttctcag    900

ggcaacagca ggaaaggccc tcctgaggcc catggtgccc tgtga                    945


<210>  564
<211>  314
<212>  PRT
<213>  Homosapiens

<400>  564

Met Ala Phe Ser Ala Arg Ala Gln Cys Gly Gly Ser Arg Cys Gly Phe 
1               5                   10                  15      


Glu Met Gln Asn Asp Thr Gly Glu Phe Ile Gly Leu Tyr Met Pro Trp 
            20                  25                  30          


Lys Trp Ser Asn Ser Asn Cys Ile Ile Asp Ala Lys Asp His Lys Ser 
        35                  40                  45              


Ile Gln Met Asn Gly Ala Lys Val Asp Lys Val Ala Gly Arg Phe Asn 
    50                  55                  60                  


His Gln Phe Lys Thr Tyr Ala Ile Cys Arg Ala Ile Arg Arg Met Ala 
65                  70                  75                  80  


Phe Val Lys Leu Phe Phe Val Pro Ile Arg Gly Phe Ser Leu Thr Ser 
                85                  90                  95      


Ala Leu Ala Cys Thr Gln Gln Ser Pro Phe Ser Leu Ile Thr Ser Ser 
            100                 105                 110         


Val Val Thr Val Asn Arg Ile Leu Leu Gly Ala Thr Glu Cys Leu Leu 
        115                 120                 125             


Lys Ile Tyr Gly Ser Pro Glu Lys Thr Gly Ser Asp Arg Asn Leu Gln 
    130                 135                 140                 


Thr Arg Thr His Ala Ser Arg Arg Gly Gln Thr Tyr Val Leu Tyr Asp 
145                 150                 155                 160 


Ala Ala Leu Ala Thr Pro Ser Leu His Pro Lys Ala Ala Glu Ser Leu 
                165                 170                 175     


Thr Met His Leu Ala Asp Gly Ala Ala Pro Pro Ser Ala Glu Leu Ala 
            180                 185                 190         


Val Ser Leu Lys His Ala Pro Arg Leu Ala Asp Leu Ala Gly Pro Phe 
        195                 200                 205             


Val Gln Thr Thr Pro Arg Asn Phe Leu Pro Arg Pro Arg Thr Leu His 
    210                 215                 220                 


Pro Asn Phe Arg Asp Ser Ser Gly His Arg Arg Leu Gly Val Arg Phe 
225                 230                 235                 240 


Cys Gln Phe Thr Val Ser Leu Leu His Ser Ala Gly Cys Cys Gln His 
                245                 250                 255     


Val Glu Gly Cys Asp Arg Ser Ser Thr Cys Pro Arg Gly Gly Leu Val 
            260                 265                 270         


Val Leu Pro Cys Trp Ala Glu Gln Pro His Glu Ile Ser Ser Asn Val 
        275                 280                 285             


Gln Ser Arg Gly Val Thr Glu Leu Pro Ile Ser Gln Gly Asn Ser Arg 
    290                 295                 300                 


Lys Gly Pro Pro Glu Ala His Gly Ala Leu 
305                 310                 


<210>  565
<211>  261
<212>  DNA
<213>  Homosapiens

<400>  565
atggagggca tggacgtgga ccgggacctg gagctgatgc agaatttcaa ctacctgagc     60

accaccaaca aagacgtgct catctccaag ttccagaggc tgctcggctt ccagctcaac    120

cctgccagtt gcgccttctt cctggacagg accaactgga acctacaagc agcaattggt    180

gcctcttatg cctttgagag ctcaaacatc agtgtgccct ctgtgtcctt tgttgaagat    240

gtcaccctag aggaagggta g                                              261


<210>  566
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  566

Met Glu Gly Met Asp Val Asp Arg Asp Leu Glu Leu Met Gln Asn Phe 
1               5                   10                  15      


Asn Tyr Leu Ser Thr Thr Asn Lys Asp Val Leu Ile Ser Lys Phe Gln 
            20                  25                  30          


Arg Leu Leu Gly Phe Gln Leu Asn Pro Ala Ser Cys Ala Phe Phe Leu 
        35                  40                  45              


Asp Arg Thr Asn Trp Asn Leu Gln Ala Ala Ile Gly Ala Ser Tyr Ala 
    50                  55                  60                  


Phe Glu Ser Ser Asn Ile Ser Val Pro Ser Val Ser Phe Val Glu Asp 
65                  70                  75                  80  


Val Thr Leu Glu Glu Gly 
                85      


<210>  567
<211>  1988
<212>  DNA
<213>  Homosapiens

<400>  567
gtaagtcaac aacatcctgg gactgggaca cactttctgg gcactgctgg ccagtcccaa     60

aatggaacat aaggaagtgg ttcttctact tcttttattt ctgaaatcag gtcaaggaga    120

gcctctggat gactatgtaa atgcccaggg ggcttcactg ttcagtgtca ctaagaagca    180

gctgggggca ggaagcagag aagaatgtgc agcaaaatgt gaggaggaca aagaattcac    240

ctgcagggca ttccaatatc acagtaaaga gcaacaatgt gtgataatgg ctgaaaacaa    300

gaagtcctcc ataatcatta ggatgagaga tgtagtttta tttgaaaagt aaatgtatct    360

ttcagagtgc aagactggga atggaaagaa ctacagaggg acgatgtcca aaacaaaaaa    420

tggcatcacc tgtcaaaaat ggagttccac ttctccccgc agacctaggt aagactttcc    480

ctttcatctt tgtgttcatc tactgtaaag ttgtccctct gtgtctgtga gggattggtt    540

ccaggacccc tgtggctacc aaaatccatg cttctcaagt cccttatgta aaatggtgca    600

gtatttgcat ataacctaca taccttctct tgtgcaatcc ctaatataat gtaaatgcta    660

tgtaatcgtt gttatgctgt attgttttta tttgtattat gttttattgt catattgtta    720

ttttctctca tctttttcaa gtcttttcca tccacagttg gttgaatttg tggatgtgga    780

acccatggat acagagggcc aactgtattt aggataattt catcactttt aattcaaacc    840

agaatatgtg aataagcaga cagaaagaat ctttttgatg tcgatgttca actatttttg    900

gcaccatagt agaacatcgt tgctttctat tttttcttgg gtatggaggt ttcttgaaga    960

cctagaacat agaagaatgc ctagttaaaa aaaaaaatca atgaaactac gagttttagg   1020

ccaaatctga gaaaagacca aagatgacta tgtttgggac tgaagtaaac atatcaagtt   1080

agaactctca tcacatgttt gactcaaatt gtggagcaaa atagtaaata aaatataaaa   1140

atgacaatga agatacgtga aattcaaatg tcgcaacttg cctattattt attttagtgc   1200

atttttttgt gcttttccca gtttggtgtt aggtggcatt aagttctcag taatgacact   1260

tatcaaatag gaacttagtg cctgttactc acctttatcc attcccccaa cactcaacaa   1320

attgcctttg ctatatccct atgagatgag cagatcaaat attccccgtg agttaatgaa   1380

aactgattca accaaatggc gaagtcagag actatcgggg gccatggaga cactctgggc   1440

catttttatg aggtagtcta ggctcatctt catgagggaa ctgaggtctt ggggggtggg   1500

ggttacccca aataggttca cagaagaacc agaaataaaa cctgcctttc tagactgtaa   1560

gtcttgtgat tgtcatctaa atggttgtct ctatacagca actcatctct agaactgaaa   1620

ataagtttaa atccctcctc catccccaat aattcaagct gcatttcaga gaaaaccagg   1680

actttggaat cagacagatc aactttgaat tcttgatctg cttcttcata gctatttacg   1740

cttaggcaag ttttgttttg ttttgtttta cgttgccatt cagtcttctc atctgtaaaa   1800

tagggataat aacaccttcc tcaaatggtt ttttttatta ggactaaaag agagaatgtg   1860

tggaaagatg ttagtggaat tcctggcaca tagttcacat ggacaaaatg gtgttaacta   1920

tgaaaatttt tacagagaaa agggcaactg acaaaagcag gtgtttggaa tgaattaaga   1980

ccatggca                                                            1988


<210>  568
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  568

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Ala Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Arg Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Lys 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


<210>  569
<211>  1077
<212>  DNA
<213>  Homosapiens

<400>  569
atcctgggac tgggacacac tttctgggca ctgctggcca gtcccaaaat ggaacataag     60

gaagtggttc ttctacttct tttatttctg aaatcaggtc aaggagagcc tctggatgac    120

tatgtaaatg cccagggggc ttcactgttc agtgtcacta agaagcagct gggggcagga    180

agcagagaag aatgtgcagc aaaatgtgag gaggacaaag aattcacctg cagggcattc    240

caatatcaca gtaaagagca acaatgtgtg ataatggctg aaaacaagaa gtcctccata    300

atcattagga tgagagatgt agttttattt gaaaagtaaa ggtgaccatg gtccttgggc    360

cctaacgtct ggatgaagcc ttgtaaaaca gaaatactga ggtgttttaa tcctcagaaa    420

catttagatt gggacacaaa tcttattttt tactcttaaa tttttcacat tttgggggac    480

atggtctata tttttctcag atttctgaaa tgttgtcttt taaaaatgtg taaaagttac    540

agtccctttt ctatagttta ttttaaaatg tgggtcaata gtcccactgc ttagaataag    600

gggcacacag gatttcaata gaaattgcat gcctttttag atgtgcaaat gtttcattaa    660

gcgtatgaat atttgaagag atgtatgaca ctttgaaaac tgtttcctct actgtgttgg    720

tggccaggta ttaagaccgt taataataac aatttagctc tccaaatatt ctgcatcaca    780

ggtgttaaag aggactggaa acaccttagt tcttgtattc ttgaggatga tttgccatat    840

tgtgtctagt atcacggcaa aactctaagt agcattttaa atagtattta tttgggttgg    900

aattatttat atgcattgac tcatcttcct gggtttcatt agctgtacgc attgtacttt    960

cttccttacc actatttatc tcgaattctt gagattaaag tacagattaa atctaaactt   1020

tatctggtgc agttattagt tcttacaagt agcaagcaaa tggtaaactg aatagga      1077


<210>  570
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  570

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Ala Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Arg Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Lys 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


<210>  571
<211>  1430
<212>  DNA
<213>  Homosapiens

<400>  571
atcctgggac tgggacacac tttctgggca ctgctggcca gtcccaaaat ggaacataag     60

gaagtggttc ttctacttct tttatttctg aaatcaggtc aaggagagcc tctggatgac    120

tatgtaaatg cccagggggc ttcactgttc agtgtcacta agaagcagct gggggcagga    180

agcagagaag aatgtgcagc aaaatgtgag gaggacaaag aattcacctg cagggcattc    240

caatatcaca gtaaagagca acaatgtgtg ataatggctg aaaacaagaa gtcctccata    300

atcattagga tgagagatgt agttttattt gaaaagtaaa gtgagtacat tttcttcctc    360

ctcctcctac tgtcctcccc atcctcccac tcttcctctt tctctattct atctttaatt    420

tatgagacca gaggaggaag gcgctatggt gttgtaaaat tgaattctga gttaggacag    480

gatttgatta ctaactaacc atgtcagctt gagtatatta cttcacctcc tagatttaat    540

ttttttgttg ttcaaaaaat gaaaggatta gatttacaaa atcacttcta cctctatgac    600

cctgaaaata agatttttaa aatattattt tatatttaac aaggagatgg gaagtctaag    660

cattcctttt ggtcttggct tcttattctg cagggtgacc atggtccttg ggccctaacg    720

tctggatgaa gccttgtaaa acagaaatac tgaggtgttt taatcctcag aaacatttag    780

attgggacac aaatcttatt ttttactctt aaatttttca cattttgggg gacatggtct    840

atatttttct cagatttctg aaatgttgtc ttttaaaaat gtgtaaaagt tacagtccct    900

tttctatagt ttattttaaa atgtgggtca atagtcccac tgcttagaat aaggggcaca    960

caggatttca atagaaattg catgcctttt tagatgtgca aatgtttcat taagcgtatg   1020

aatatttgaa gagatgtatg acactttgaa aactgtttcc tctactgtgt tggtggccag   1080

gtattaagac cgttaataat aacaatttag ctctccaaat attctgcatc acaggtgtta   1140

aagaggactg gaaacacctt agttcttgta ttcttgagga tgatttgcca tattgtgtct   1200

agtatcacgg caaaactcta agtagcattt taaatagtat ttatttgggt tggaattatt   1260

tatatgcatt gactcatctt cctgggtttc attagctgta cgcattgtac tttcttcctt   1320

accactattt atctcgaatt cttgagatta aagtacagat taaatctaaa ctttatctgg   1380

tgcagttatt agttcttaca agtagcaagc aaatggtaaa ctgaatagga              1430


<210>  572
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  572

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Ala Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Arg Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Lys 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


<210>  573
<211>  1039
<212>  DNA
<213>  Homosapiens

<400>  573
gtcaacaaca tcctgggact gggacacact ttctgggcac tgctggccag tcccaaaatg     60

gaacataagg aagtggttct tctacttctt ttatttctga aatcaggtca aggagagcct    120

ctggatgact atgtaaatgc ccagggggct tcactgttca gtgtcactaa gaagcagctg    180

ggggcaggaa gcagagaaga atgtgcagca aaatgtgagg aggacaaaga attcacctgc    240

agggcattcc aatatcacag taaagagcaa caatgtgtga taatggctga aaacaagaag    300

tcctccataa tcattaggat gagagatgta gttttatttg aaaagtaaat gtatctttca    360

gagtgcaaga ctgggaatgg aaagaactac agagggacga tgtccaaaac aaaaaatggc    420

atcacctgtc aaaaatggag ttccacttct ccccgcagac ctagataaag aaatgggggc    480

tcagagcagt caagaacatg ccccaagtta ttcgtcagtg aggcggaaat tgtggtgtcc    540

ttgttttgta tcttagcaaa atcacaggta atacgcaaca gacctttagg attcatccca    600

agccaaaaat gggggaaaaa atccacaaat tccaagagcc taatataagg tttgttcaca    660

tattgtcatt acataccaga gcacaccttc atttaaaaca catcaagact ccgtgaaatg    720

tcaattgctc caagtggaag acttacctga aatgctatga gatagcacaa tgcagccagc    780

tcagaaagag ctcgccattg aacattatta ccatgctgac ccatcttcaa gagcagagaa    840

ccagcatgca tgtagaaatg tcctttcatt tctaagaaag tagctgacag ttcatcattt    900

ccacccaaag aagatttcgc agactgaaga gcactatcaa aactgtaata tgaaaatatc    960

aaacagatga tacacactta ctgcactgtg aataatcatg gttcatttaa ttcaaaacaa   1020

aataaaaatt ttatttcaa                                                1039


<210>  574
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  574

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Ala Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Arg Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Lys 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


<210>  575
<211>  934
<212>  DNA
<213>  Homosapiens

<400>  575
gtcaacaaca tcctgggact gggacacact ttctgggcac tgctggccag tcccaaaatg     60

gaacataagg aagtggttct tctacttctt ttatttctga aatcaggtca aggagagcct    120

ctggatgact atgtaaatgc ccagggggct tcactgttca gtgtcactaa gaagcagctg    180

ggggcaggaa gcagagaaga atgtgcagca aaatgtgagg aggacaaaga attcacctgc    240

agggcattcc aatatcacag taaagagcaa caatgtgtga taatggctga aaacaagaag    300

tcctccataa tcattaggat gagagatgta gttttatttg aaaagtaaat gtatctttca    360

gagtgcaaga ctgggaatgg aaagaactac agagggacga tgtccaaaac aaaaaatggc    420

atcacctgtc aaaaatggag ttccacttct ccccgcagac ctagataaag aaatgggggc    480

tcagagcagt caagaacatg ccccaagtta ttcgtcagtg aggcggaaat tgtggtgtcc    540

ttgtgtttgt tcacatattg tcattacata ccagagcaca ccttcattta aaacacatca    600

agactccgtg aaatgtcaat tgctccaagt ggaagactta cctgaaatgc tatgagatag    660

cacaatgcag ccagctcaga aagagctcgc cattgaacat tattaccatg ctgacccatc    720

ttcaagagca gagaaccagc atgcatgtag aaatgtcctt tcatttctaa gaaagtagct    780

gacagttcat catttccacc caaagaagat ttcgcagact gaagagcact atcaaaactg    840

taatatgaaa atatcaaaca gatgatacac acttactgca ctgtgaataa tcatggttca    900

tttaattcaa aacaaaataa aaattttatt tcaa                                934


<210>  576
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  576

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Ala Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Arg Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Lys 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


<210>  577
<211>  1360
<212>  DNA
<213>  Homosapiens

<400>  577
gtcaacaaca tcctgggact gggacacact ttctgggcac tgctggccag tcccaaaatg     60

gaacataagg aagtggttct tctacttctt ttatttctga aatcaggtca aggagagcct    120

ctggatgact atgtaaatgc ccagggggct tcactgttca gtgtcactaa gaagcagctg    180

ggggcaggaa gcagagaaga atgtgcagca aaatgtgagg aggacaaaga attcacctgc    240

agggcattcc aatatcacag taaagagcaa caatgtgtga taatggctga aaacaagaag    300

tcctccataa tcattaggat gagagatgta gttttatttg aaaagtaaat gtatctttca    360

gagtgcaaga ctgggaatgg aaagaactac agagggacga tgtccaaaac aaaaaatggc    420

atcacctgtc aaaaatggag ttccacttct ccccgcagac ctagattctc acctgctaca    480

cacccctcag agggactgga ggaatccaga caacgatgcg caggggccct ggtgttatac    540

tactgatcca gaacagagat atgactactg cgacattcct gagtgtgaag ggcaggagtg    600

gctctagaaa atgttttcat ttctgctctt cacctgtaaa ataatttgtt gtaaagcccc    660

ttcccacagg gatattatta ataattgcgt aacgtgttca cctctcggaa aggagcaaaa    720

ctttgctcag atcccagaat taacctgatt tttttttttt tttctgagac agaattttgc    780

tctcattgcc caggctagag tgcaatggtg cgatctcggc tcaccacaac ctccgcctcc    840

gggttcaagc gattctccta cctcagcctc ccaagtagct ggaattacat gcatgtgcca    900

ccatgcctgg ctaattttac atttttagta gagacagggt ttctccatgt tggtcaggct    960

ggtcttgaac tctcgacctc aggtgagccg cccgcctcag cctcccaaag tgctgggatt   1020

acaggcgtga gccaccatgc ccagcagacc tgaattatta ttattattaa aatgttacat   1080

caacatgtac aaatataaaa ctacatctaa actctaagta caaacttctt atgcttaaaa   1140

ctcttacaca gtgttaaccc caagacagat ttgcaattaa gtagttaaaa taaaacaaca   1200

aagtcaataa aaatcaaata aacaatatac atttaatgtg gtagactttg ctgttttgct   1260

gaagctaagc aaggaaccag tttttaaatc agcaatccgt tattttaatg gactgagcaa   1320

tttaatagtg cacctcaaag gtcaatgcta aaaactaaaa                         1360


<210>  578
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  578

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Ala Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Arg Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Lys 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


<210>  579
<211>  1752
<212>  DNA
<213>  Homosapiens

<400>  579
atgtaagtca acaacatcct gggactggga cacactttct gggcactgct ggccagtccc     60

aaaatggaac ataaggaagt ggttcttcta cttcttttat ttctgaaatc aggtcaagga    120

gagcctctgg atgactatgt aaatgcccag ggggcttcac tgttcagtgt cactaagaag    180

cagctggggg caggaagcag agaagaatgt gcagcaaaat gtgaggagga caaagaattc    240

acctgcaggg cattccaata tcacagtaaa gagcaacaat gtgtgataat ggctgaaaac    300

aagaagtcct ccataatcat taggatgaga gatgtagttt tatttgaaaa gtaaaggctg    360

caatcaagat gttggcatgg ctggggtctc atctgaaggc tggactggag aagaatctac    420

ttccaaactt atgtggtagt tggaagaatt tagttcctca aggctgctaa actgatggcc    480

tgtgttcctt gcctctggga tggtagcttg cttcaacaaa gtgtgcaagc agagaagaca    540

gagagagtcc gctagcaaga tagaagccac aatctcttgt aatctatcat ttttgctgta    600

ttctactggt taaaaataac tcattaggtt agcctactgg ctctcaaggg gaagagatta    660

tacaaaggca tgaatttctg gaggaggcaa tgagggcaaa gaactctgaa aagtctctct    720

tccacaatct gaagaacttc tagaaagtag aaggaagcga tattgcttag ggatggacaa    780

cttggcactg gttatgtgtt ccaagtgagg taaccttgtt cccaggaata aagagaacca    840

gatgactata aacatttccc taaactgaaa tgcactgttg tatgttcacc tgcaatgaat    900

ggtgtaagct gaatataaga tttttgacaa aataaaaatt ttgctgtgtt ctcagatctg    960

gcaggctcct gcccttgtgc aaacaatgtt cctggcaact attcatctcc ttaggtaaat   1020

aagaattgga gaaaagctgt gcttagatag ggtgcatttg ctcttgcctt ggaaggctgt   1080

tttctgataa ggttctatat cctctgcaaa tcaaatcagg cacttacagt gtgagtatgc   1140

attctcttcc tgccagtctg gagatgatca aaaagcctat aacaggcttg gcctattttc   1200

ctattgggtt gctgggcttt ttttctttat ttacttgtag agagttttag acctctgtgt   1260

atgtatggtg tacaagtgac aatattcaga tctgtaaact gtaacccagt ctgggagcaa   1320

agaagatata gaaaaatgac ttttacttcc ggcttgagta gtaaaattga gattcaaatt   1380

ttgcatatag aagtactata tggctaactt atttggggag caaagctgac ttaccataag   1440

tctatctcaa atagaaatga aacactcaat ttgtgaaata tgctgagttt taatgcgtgt   1500

gggggcaggg tgaattaaca tttgtgatgc aaggagaaga gcaatctata cttaccactg   1560

tctatttgac attgtttggg gactactgct acactctaag tcattttacc ttataacgca   1620

gagttgtaac acgctactct gagcagctca tgacatctgc ttgaaattta agttgggccc   1680

ctagtatgtg tttattataa agattttgat gctgcttttc agagttgggt aacctacttt   1740

accccctaag ct                                                       1752


<210>  580
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  580

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Ala Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Arg Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Lys 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


<210>  581
<211>  915
<212>  DNA
<213>  Homosapiens

<400>  581
atggcgaaga ttgagaaaaa cgctcccacg atggaaaaaa agccagaact gtttaacatc     60

atggaagtag atggagtccc tacgttgata ttatcaaaag aatggtggga aaaagtatgt    120

aatttccaag ccaagcctga tgatcttatt ctggcaactt acccaaagtc aggtacaaca    180

tggatgcatg aaattttaga catgattcta aatgatggtg atgtggagaa atgcaaaaga    240

gcccagactc tagatagaca cgctttcctt gaactgaaat ttccccataa agaaaaacca    300

gatttggagt tcgttcttga aatgtcctca ccacaactga taaaaacaca tctcccttca    360

catctgattc caccatctat ctggaaagaa aactgcaaga ttgtctatgt ggccagaaat    420

cccaaggatt gcctggtgtc ctactaccac tttcacagga tggcttcctt tatgcctgat    480

cctcagaact tagaggaatt ttatgagaaa ttcatgtccg gaaaagttgt tggcgggtcc    540

tggtttgacc atgtgaaagg atggtgggct gcaaaagaca tgcaccggat cctctacctc    600

ttctacgagg atattaaaaa agacccaaag cgggaaattg agaagatact gaagttcctg    660

gaaaaagaca tatcagagga aattctgaat aaaatcatct atcacacctc ctttgatgta    720

atgaagcaaa acccaatgac caactatacc actttgccca ccagcattat ggaccactcc    780

atctcccctt ttatgaggaa agggatgcct ggagactgga agaactattt tactgtggcc    840

caaaatgaag aatttgacaa ggactaccag aagaagatgg caggaagcac cctaaccttc    900

cgcacagaga tctga                                                     915


<210>  582
<211>  304
<212>  PRT
<213>  Homosapiens

<400>  582

Met Ala Lys Ile Glu Lys Asn Ala Pro Thr Met Glu Lys Lys Pro Glu 
1               5                   10                  15      


Leu Phe Asn Ile Met Glu Val Asp Gly Val Pro Thr Leu Ile Leu Ser 
            20                  25                  30          


Lys Glu Trp Trp Glu Lys Val Cys Asn Phe Gln Ala Lys Pro Asp Asp 
        35                  40                  45              


Leu Ile Leu Ala Thr Tyr Pro Lys Ser Gly Thr Thr Trp Met His Glu 
    50                  55                  60                  


Ile Leu Asp Met Ile Leu Asn Asp Gly Asp Val Glu Lys Cys Lys Arg 
65                  70                  75                  80  


Ala Gln Thr Leu Asp Arg His Ala Phe Leu Glu Leu Lys Phe Pro His 
                85                  90                  95      


Lys Glu Lys Pro Asp Leu Glu Phe Val Leu Glu Met Ser Ser Pro Gln 
            100                 105                 110         


Leu Ile Lys Thr His Leu Pro Ser His Leu Ile Pro Pro Ser Ile Trp 
        115                 120                 125             


Lys Glu Asn Cys Lys Ile Val Tyr Val Ala Arg Asn Pro Lys Asp Cys 
    130                 135                 140                 


Leu Val Ser Tyr Tyr His Phe His Arg Met Ala Ser Phe Met Pro Asp 
145                 150                 155                 160 


Pro Gln Asn Leu Glu Glu Phe Tyr Glu Lys Phe Met Ser Gly Lys Val 
                165                 170                 175     


Val Gly Gly Ser Trp Phe Asp His Val Lys Gly Trp Trp Ala Ala Lys 
            180                 185                 190         


Asp Met His Arg Ile Leu Tyr Leu Phe Tyr Glu Asp Ile Lys Lys Asp 
        195                 200                 205             


Pro Lys Arg Glu Ile Glu Lys Ile Leu Lys Phe Leu Glu Lys Asp Ile 
    210                 215                 220                 


Ser Glu Glu Ile Leu Asn Lys Ile Ile Tyr His Thr Ser Phe Asp Val 
225                 230                 235                 240 


Met Lys Gln Asn Pro Met Thr Asn Tyr Thr Thr Leu Pro Thr Ser Ile 
                245                 250                 255     


Met Asp His Ser Ile Ser Pro Phe Met Arg Lys Gly Met Pro Gly Asp 
            260                 265                 270         


Trp Lys Asn Tyr Phe Thr Val Ala Gln Asn Glu Glu Phe Asp Lys Asp 
        275                 280                 285             


Tyr Gln Lys Lys Met Ala Gly Ser Thr Leu Thr Phe Arg Thr Glu Ile 
    290                 295                 300                 


<210>  583
<211>  2799
<212>  DNA
<213>  Homosapiens

<400>  583
agcttcgagg ccagtgggag gagggagggg ccaggcagct gagggccagg aaagatgtga     60

aaaactctag ctggtgaccg agaggaggag tagagtgtgc ccttagttca tatgaactag    120

agggagttgg tatttgcaca gcagtcaggg tcacatgagt gatcatggta cagtgagaag    180

ttctccctcc cagggccagg tcacagggtt tgtttctgtt caatccggat tcttccagta    240

aaagcttcaa cttcccacac tgaagctgag agcctcccaa agtgctggct acctgctgag    300

cgcccccgta actctgacac agtagtaatt tgagcctctg caattgccgt ctgcttcctg    360

tgaaagtcct ttccgtgccc actgaccctt gagtgggcct ttgagctgct gactttcagc    420

tggaacttga agggacccca accctgagac actatggccc tgacctcaga cctggggaaa    480

cagataaaac tgaaagaggt ggaggggacc ctcctgcagc ctgcaactgt ggacaactgg    540

agccagatcc agagcttcga ggccaaacca gatgatctcc tcatctgcac ctaccctaaa    600

gcagggacaa cgtggattca ggaaattgtg gatatgattg aacagaatgg ggacgtggag    660

aagtgccagc gagccatcat ccaacaccgc catcctttca ttgagtgggc tcggccaccc    720

caaccttctg gtgtggaaaa agccaaagca atgccctctc cacggatact aaagactcac    780

ctttccactc agctgctgcc accgtctttc tgggaaaaca actgcaagtt cctttatgta    840

gctcgaaatg ccaaagactg tatggtttcc tactaccatt tccaaaggat gaaccacatg    900

cttcctgacc ctggtacctg ggaagagtat tttgaaacct tcatcaatgg aaaagtggtt    960

tggggttcct ggtttgacca cgtgaaagga tggtgggaga tgaaagacag acaccagatt   1020

ctcttcctct tctatgagga cataaagagg gacccaaagc atgaaattcg gaaggtgatg   1080

cagttcatgg gaaagaaggt ggatgaaaca gtgctagata aaattgtcca ggagacgtca   1140

tttgagaaaa tgaaagaaaa tcccatgaca aatcgttcta cagtttccaa atctatcttg   1200

gaccagtcaa tttcctcctt catgagaaaa ggaactgtgg gggattggaa aaaccacttc   1260

actgttgccc agaatgagag gtttgatgaa atctatagaa gaaagatgga aggaacctcc   1320

ataaacttct gcatggaact ctgagcaaga tgtaaataaa attaaaaggt ggatggcaag   1380

agtgcaaata ctatcttcaa tccttcagtc ccagccagaa gaatctctga aagcatattg   1440

tgaatgtata caatgtagta caaacaatct ctgtgatgat taacagtatg tcaccacttc   1500

attttttaaa aaggatcacg tctaatgccc attttcccaa ctattctttc caaagtaaga   1560

tataaggtag cttaataaac taagtaaaac gtatgacttg agtacaaaag gattgtttta   1620

atccccatta ttctggaaag tgcatcctag tctcccagtc tataacatca taataccttg   1680

agtataagtc caaatattag gttatatcta tattaaaaac aaaatttctg tcatctgtcc   1740

tggccattca ggcaactcca gcctgggctc aatcctggag ttctgtctgg tcactatcag   1800

aaggaacact ttgagggaaa ccctggtgca gccagccctg aggaaacatg gcctgagtgc   1860

cctcactggt gggtgggaat aaaatggaag tgcacagagg agatgtcaga agaccaaaac   1920

ttggtgaata gtcccagtgc taggtcatat aggaaacaga aagcatgaca gtggcctttt   1980

gggaacccaa gttacgtcct ggtgaaagca gaaaggagga gacaggatgg ctgtcaacaa   2040

cgtcagcatg ggcatggctc ccaggcatgg aggtaattgg gtcttggctt caatgccacc   2100

cttttgggaa gccctaaacc aagtgaggtg ttcttttccc ttgcttccca tatttgtccc   2160

agttgcagcc ctgttgttat gtatttactc ttcaatttct tatttatacc tctcactcaa   2220

ttgttaattc tttgggttca gtctcatgcc atatttactc ctagtaccta atgcagtgcc   2280

tggcacacag caagtgccct tgagaacttg tagagggagt aaaaaagtgc atggataaat   2340

gactgcagca aatcacaaat tttgaacttt gacccttttc ttttagtccc aaatagtggc   2400

attccatagc tgagggtagt aggagcagtt caccctggga gcagacaata agaggaagaa   2460

tgaagccaac taaaattctg aatgcttttt gttggatttc gtagggtatt ttttttaaaa   2520

tagggtcttg ctatgttgcc caggctggtc ttaactgact gctttttatt attaccatgc   2580

actggcaatt ccaaacaatg tcagtgttaa aatgcttctc cctgaaaaag agaaaaaaaa   2640

aaggaaaaaa agaaaagaaa agtgaaaaga aaaactctta ttggcctaag ttctaaataa   2700

tagctaggtt accactgagt tttaactata tgtatatgag cttcaaataa gcaccttttt   2760

attatgtaaa taaataaaag ttatctgtat ccccaaaaa                          2799


<210>  584
<211>  296
<212>  PRT
<213>  Homosapiens

<400>  584

Met Ala Leu Thr Ser Asp Leu Gly Lys Gln Ile Lys Leu Lys Glu Val 
1               5                   10                  15      


Glu Gly Thr Leu Leu Gln Pro Ala Thr Val Asp Asn Trp Ser Gln Ile 
            20                  25                  30          


Gln Ser Phe Glu Ala Lys Pro Asp Asp Leu Leu Ile Cys Thr Tyr Pro 
        35                  40                  45              


Lys Ala Gly Thr Thr Trp Ile Gln Glu Ile Val Asp Met Ile Glu Gln 
    50                  55                  60                  


Asn Gly Asp Val Glu Lys Cys Gln Arg Ala Ile Ile Gln His Arg His 
65                  70                  75                  80  


Pro Phe Ile Glu Trp Ala Arg Pro Pro Gln Pro Ser Gly Val Glu Lys 
                85                  90                  95      


Ala Lys Ala Met Pro Ser Pro Arg Ile Leu Lys Thr His Leu Ser Thr 
            100                 105                 110         


Gln Leu Leu Pro Pro Ser Phe Trp Glu Asn Asn Cys Lys Phe Leu Tyr 
        115                 120                 125             


Val Ala Arg Asn Ala Lys Asp Cys Met Val Ser Tyr Tyr His Phe Gln 
    130                 135                 140                 


Arg Met Asn His Met Leu Pro Asp Pro Gly Thr Trp Glu Glu Tyr Phe 
145                 150                 155                 160 


Glu Thr Phe Ile Asn Gly Lys Val Val Trp Gly Ser Trp Phe Asp His 
                165                 170                 175     


Val Lys Gly Trp Trp Glu Met Lys Asp Arg His Gln Ile Leu Phe Leu 
            180                 185                 190         


Phe Tyr Glu Asp Ile Lys Arg Asp Pro Lys His Glu Ile Arg Lys Val 
        195                 200                 205             


Met Gln Phe Met Gly Lys Lys Val Asp Glu Thr Val Leu Asp Lys Ile 
    210                 215                 220                 


Val Gln Glu Thr Ser Phe Glu Lys Met Lys Glu Asn Pro Met Thr Asn 
225                 230                 235                 240 


Arg Ser Thr Val Ser Lys Ser Ile Leu Asp Gln Ser Ile Ser Ser Phe 
                245                 250                 255     


Met Arg Lys Gly Thr Val Gly Asp Trp Lys Asn His Phe Thr Val Ala 
            260                 265                 270         


Gln Asn Glu Arg Phe Asp Glu Ile Tyr Arg Arg Lys Met Glu Gly Thr 
        275                 280                 285             


Ser Ile Asn Phe Cys Met Glu Leu 
    290                 295     


<210>  585
<211>  2832
<212>  DNA
<213>  Homosapiens

<400>  585
agcttcgagg ccagtgggag gagggagggg ccaggcagct gagggccagg aaagatgtga     60

aaaactctag ctggtgaccg agaggaggag tagagtgtgc ccttagttca tatgaactag    120

agggagttgg tatttgcaca gcagtcaggg tcacatgagt gatcatggta cagtgagaag    180

ttctccctcc cagggccagg tcacagggtt tgtttctgtt caatccggat tcttccagta    240

aaagcttcaa cttcccacac tgaagctgag agcctcccaa agtgctggct acctgctgag    300

cgcccccgta actctgacac agtagtaatt tgagcctctg caattgccgt ctgcttcctg    360

tgaaagtcct ttccgtgccc actgaccctt gagtgggcct ttgagctgct gactttcagc    420

tggaacttga agggacccca accctgagac actatggccc tgacctcaga cctggggaaa    480

cagataaaac tgaaagaggt ggaggggacc ctcctgcagc ctgcaactgt ggacaactgg    540

agccagatcc agagcttcga ggccaaacca gatgatctcc tcatctgcac ctaccctaaa    600

gcagggacaa cgtggattca ggaaattgtg gatatgattg aacagaatgg ggacgtggag    660

aagtgccagc gagccatcat ccaacaccgc catcctttca ttgagtgggc tcggccaccc    720

caaccttctg agacaggatt tcaccatgtt gcccaggctg gtctcaaact cctgagctca    780

agcaatccac ctgcctcaac ctcccaaagt gccaagatta cagacctgct gccaccgtct    840

ttctgggaaa acaactgcaa gttcctttat gtagctcgaa atgccaaaga ctgtatggtt    900

tcctactacc atttccaaag gatgaaccac atgcttcctg accctggtac ctgggaagag    960

tattttgaaa ccttcatcaa tggaaaagtg gtttggggtt cctggtttga ccacgtgaaa   1020

ggatggtggg agatgaaaga cagacaccag attctcttcc tcttctatga ggacataaag   1080

agggacccaa agcatgaaat tcggaaggtg atgcagttca tgggaaagaa ggtggatgaa   1140

acagtgctag ataaaattgt ccaggagacg tcatttgaga aaatgaaaga aaatcccatg   1200

acaaatcgtt ctacagtttc caaatctatc ttggaccagt caatttcctc cttcatgaga   1260

aaaggaactg tgggggattg gaaaaaccac ttcactgttg cccagaatga gaggtttgat   1320

gaaatctata gaagaaagat ggaaggaacc tccataaact tctgcatgga actctgagca   1380

agatgtaaat aaaattaaaa ggtggatggc aagagtgcaa atactatctt caatccttca   1440

gtcccagcca gaagaatctc tgaaagcata ttgtgaatgt atacaatgta gtacaaacaa   1500

tctctgtgat gattaacagt atgtcaccac ttcatttttt aaaaaggatc acgtctaatg   1560

cccattttcc caactattct ttccaaagta agatataagg tagcttaata aactaagtaa   1620

aacgtatgac ttgagtacaa aaggattgtt ttaatcccca ttattctgga aagtgcatcc   1680

tagtctccca gtctataaca tcataatacc ttgagtataa gtccaaatat taggttatat   1740

ctatattaaa aacaaaattt ctgtcatctg tcctggccat tcaggcaact ccagcctggg   1800

ctcaatcctg gagttctgtc tggtcactat cagaaggaac actttgaggg aaaccctggt   1860

gcagccagcc ctgaggaaac atggcctgag tgccctcact ggtgggtggg aataaaatgg   1920

aagtgcacag aggagatgtc agaagaccaa aacttggtga atagtcccag tgctaggtca   1980

tataggaaac agaaagcatg acagtggcct tttgggaacc caagttacgt cctggtgaaa   2040

gcagaaagga ggagacagga tggctgtcaa caacgtcagc atgggcatgg ctcccaggca   2100

tggaggtaat tgggtcttgg cttcaatgcc acccttttgg gaagccctaa accaagtgag   2160

gtgttctttt cccttgcttc ccatatttgt cccagttgca gccctgttgt tatgtattta   2220

ctcttcaatt tcttatttat acctctcact caattgttaa ttctttgggt tcagtctcat   2280

gccatattta ctcctagtac ctaatgcagt gcctggcaca cagcaagtgc ccttgagaac   2340

ttgtagaggg agtaaaaaag tgcatggata aatgactgca gcaaatcaca aattttgaac   2400

tttgaccctt ttcttttagt cccaaatagt ggcattccat agctgagggt agtaggagca   2460

gttcaccctg ggagcagaca ataagaggaa gaatgaagcc aactaaaatt ctgaatgctt   2520

tttgttggat ttcgtagggt atttttttta aaatagggtc ttgctatgtt gcccaggctg   2580

gtcttaactg actgcttttt attattacca tgcactggca attccaaaca atgtcagtgt   2640

taaaatgctt ctccctgaaa aagagaaaaa aaaaaggaaa aaaagaaaag aaaagtgaaa   2700

agaaaaactc ttattggcct aagttctaaa taatagctag gttaccactg agttttaact   2760

atatgtatat gagcttcaaa taagcacctt tttattatgt aaataaataa aagttatctg   2820

tatccccaaa aa                                                       2832


<210>  586
<211>  307
<212>  PRT
<213>  Homosapiens

<400>  586

Met Ala Leu Thr Ser Asp Leu Gly Lys Gln Ile Lys Leu Lys Glu Val 
1               5                   10                  15      


Glu Gly Thr Leu Leu Gln Pro Ala Thr Val Asp Asn Trp Ser Gln Ile 
            20                  25                  30          


Gln Ser Phe Glu Ala Lys Pro Asp Asp Leu Leu Ile Cys Thr Tyr Pro 
        35                  40                  45              


Lys Ala Gly Thr Thr Trp Ile Gln Glu Ile Val Asp Met Ile Glu Gln 
    50                  55                  60                  


Asn Gly Asp Val Glu Lys Cys Gln Arg Ala Ile Ile Gln His Arg His 
65                  70                  75                  80  


Pro Phe Ile Glu Trp Ala Arg Pro Pro Gln Pro Ser Glu Thr Gly Phe 
                85                  90                  95      


His His Val Ala Gln Ala Gly Leu Lys Leu Leu Ser Ser Ser Asn Pro 
            100                 105                 110         


Pro Ala Ser Thr Ser Gln Ser Ala Lys Ile Thr Asp Leu Leu Pro Pro 
        115                 120                 125             


Ser Phe Trp Glu Asn Asn Cys Lys Phe Leu Tyr Val Ala Arg Asn Ala 
    130                 135                 140                 


Lys Asp Cys Met Val Ser Tyr Tyr His Phe Gln Arg Met Asn His Met 
145                 150                 155                 160 


Leu Pro Asp Pro Gly Thr Trp Glu Glu Tyr Phe Glu Thr Phe Ile Asn 
                165                 170                 175     


Gly Lys Val Val Trp Gly Ser Trp Phe Asp His Val Lys Gly Trp Trp 
            180                 185                 190         


Glu Met Lys Asp Arg His Gln Ile Leu Phe Leu Phe Tyr Glu Asp Ile 
        195                 200                 205             


Lys Arg Asp Pro Lys His Glu Ile Arg Lys Val Met Gln Phe Met Gly 
    210                 215                 220                 


Lys Lys Val Asp Glu Thr Val Leu Asp Lys Ile Val Gln Glu Thr Ser 
225                 230                 235                 240 


Phe Glu Lys Met Lys Glu Asn Pro Met Thr Asn Arg Ser Thr Val Ser 
                245                 250                 255     


Lys Ser Ile Leu Asp Gln Ser Ile Ser Ser Phe Met Arg Lys Gly Thr 
            260                 265                 270         


Val Gly Asp Trp Lys Asn His Phe Thr Val Ala Gln Asn Glu Arg Phe 
        275                 280                 285             


Asp Glu Ile Tyr Arg Arg Lys Met Glu Gly Thr Ser Ile Asn Phe Cys 
    290                 295                 300                 


Met Glu Leu 
305         


<210>  587
<211>  1664
<212>  DNA
<213>  Homosapiens

<400>  587
aattcataaa caagagctcc agttccctgg aacctgagtc gggagacctg cagctcactt     60

tctccctgtt tgctggccag cagggtttgt ggccgcctct gctgtgacgc cacagcctgg    120

tgaggagggg gctgcagttc ctcaggaaac tgccagtgga caaagtcata aacaagagtt    180

ccagttccct ggaacctgag tcgggaggcc tgcaactcac tttctccctg tttgctggcc    240

cagacaggcc tgtgctagag ggctggatag tgtggtagtg tggtggatag agtgctgcct    300

ctatccacaa cgcagccata tgctgactga agataacttt gtgtctggaa gagccctctg    360

atttcttaca ctaatggcct tacacgacat ggaggatttt acatttgatg gaacaaagcg    420

cttaagtgtc aactacgtga agggaattct tcaaccgaca gacacctgtg acatctggga    480

taagatctgg aacttccaag ccaagcctga tgacctgctt atttctacct atcctaaagc    540

aggaacaaca tggactcagg agatagtgga attaatacaa aatgaaggtg atgtggagaa    600

aagtaaacgg gcaccgactc atcaacgatt tcctttcctc gaaatgaaaa tcccatcctt    660

aggatctggt ttggaacaag ctcatgcaat gccctcacca cggatcctga aaacacatct    720

tccctttcac ttgctgccac catccttgct agagaaaaac tgtaagataa tctatgtagc    780

aagaaatccc aaggacaaca tggtgtccta ttaccatttc caaagaatga ataaagctct    840

tcctgctcca ggaacatggg aagagtattt tgagactttt ctggctggga aagtgtgctg    900

gggctcctgg catgaacatg tgaaaggatg gtgggaagcc aaagacaaac accgtattct    960

ctatctcttc tatgaggaca tgaagaagaa cccaaagcat gaaattcaga agctggcaga   1020

atttattggg aagaaattag atgacaaagt tctagataaa attgtccatt acacttcgtt   1080

tgatgtcatg aaacagaatc caatggcaaa ctattcatcg attcctgctg aaatcatgga   1140

ccactccatt tctccattca tgagaaaagg ggcagtggga gactggaaga aacacttcac   1200

cgtggctcag aatgagagat ttgatgaaga ttacaagaag aaaatgactg ataccagact   1260

aactttccac ttccagttct agtaaggaag aaaaactgaa aatgttttag tttattaccc   1320

agtatatttg ggtaataatg aaagtttaat tctcataaca aatgatatca gattccagtt   1380

atcagaatag tttactgtgt ttgctcttat tcactctact aaaaaattat tttaaaaggc   1440

tggaggcaag gtggtgacag gcagcagggt ggcgacatgg agagagggaa gctcaataaa   1500

tcactaggta caatcctggt atcattgcca attatcatca tatttacatt ttctacaatc   1560

atgtgcttat taacatattg gaaatgcttc agtcctcaca tgataataca ctaacatttt   1620

cagattaagt tttggttcaa gttaattttt tttttttttt tttt                    1664


<210>  588
<211>  302
<212>  PRT
<213>  Homosapiens

<400>  588

Met Ala Leu His Asp Met Glu Asp Phe Thr Phe Asp Gly Thr Lys Arg 
1               5                   10                  15      


Leu Ser Val Asn Tyr Val Lys Gly Ile Leu Gln Pro Thr Asp Thr Cys 
            20                  25                  30          


Asp Ile Trp Asp Lys Ile Trp Asn Phe Gln Ala Lys Pro Asp Asp Leu 
        35                  40                  45              


Leu Ile Ser Thr Tyr Pro Lys Ala Gly Thr Thr Trp Thr Gln Glu Ile 
    50                  55                  60                  


Val Glu Leu Ile Gln Asn Glu Gly Asp Val Glu Lys Ser Lys Arg Ala 
65                  70                  75                  80  


Pro Thr His Gln Arg Phe Pro Phe Leu Glu Met Lys Ile Pro Ser Leu 
                85                  90                  95      


Gly Ser Gly Leu Glu Gln Ala His Ala Met Pro Ser Pro Arg Ile Leu 
            100                 105                 110         


Lys Thr His Leu Pro Phe His Leu Leu Pro Pro Ser Leu Leu Glu Lys 
        115                 120                 125             


Asn Cys Lys Ile Ile Tyr Val Ala Arg Asn Pro Lys Asp Asn Met Val 
    130                 135                 140                 


Ser Tyr Tyr His Phe Gln Arg Met Asn Lys Ala Leu Pro Ala Pro Gly 
145                 150                 155                 160 


Thr Trp Glu Glu Tyr Phe Glu Thr Phe Leu Ala Gly Lys Val Cys Trp 
                165                 170                 175     


Gly Ser Trp His Glu His Val Lys Gly Trp Trp Glu Ala Lys Asp Lys 
            180                 185                 190         


His Arg Ile Leu Tyr Leu Phe Tyr Glu Asp Met Lys Lys Asn Pro Lys 
        195                 200                 205             


His Glu Ile Gln Lys Leu Ala Glu Phe Ile Gly Lys Lys Leu Asp Asp 
    210                 215                 220                 


Lys Val Leu Asp Lys Ile Val His Tyr Thr Ser Phe Asp Val Met Lys 
225                 230                 235                 240 


Gln Asn Pro Met Ala Asn Tyr Ser Ser Ile Pro Ala Glu Ile Met Asp 
                245                 250                 255     


His Ser Ile Ser Pro Phe Met Arg Lys Gly Ala Val Gly Asp Trp Lys 
            260                 265                 270         


Lys His Phe Thr Val Ala Gln Asn Glu Arg Phe Asp Glu Asp Tyr Lys 
        275                 280                 285             


Lys Lys Met Thr Asp Thr Arg Leu Thr Phe His Phe Gln Phe 
    290                 295                 300         


<210>  589
<211>  6833
<212>  DNA
<213>  Homosapiens

<400>  589
ctttgacctg cagtagagcc tacgtcagag gctggcgcaa acagaagtgc agcggtggcg     60

gcggctggtt gcgggccggc ggcgggctgg cggagatgga ggatcttgtt caagatgggg    120

tggcttcacc agctacccct gggaccggga aatctaagaa ttggagaaag aaattgaaga    180

actcagatca aaacctgtta ctgaaggaac tggtgatatt attaaggcat taactgaacg    240

tctggatgct cttcttctgg aaaaagcaga gactgagcaa cagtgtcttt ctctgaaaaa    300

ggaaaatata aaaatgaagc aagaggttga ggattctgta acaaagatgg gagatgcaca    360

taaggagttg gaacaatcac atataaacta tgtgaaagaa attgaaaatt tgaaaaatga    420

gttgatggca gtacgttcca aatacagtga agacaaagct aacttacaaa agcagctgga    480

agaagcaatg aatacgcaat tagaactttc agaacaactt aaatttcaga acaactctga    540

agataatgtt aaaaaactac aagaagagat tgagaaaatt aggccaggct ttgaggagca    600

aattttatat ctgcaaaagc aattagacgc taccactgat gaaaagaagg aaacagttac    660

tcaactccaa aatatcattg aggctaattc tcagcattac caaaaaaata ttaatagttt    720

gcaggaagag cttttacagt tgaaagctat acaccaagaa gaggtgaaag agttgatgtg    780

ccagattgaa gcatcagcta aggaacatga agcagagata aataagttga acgagctaaa    840

agagaactta gtaaaacaat gtgaggcaag tgaaaagaac atccagaaga aatatgaatg    900

tgagttagaa aatttaagga aagccacctc aaatgcaaac caagacaatc agatatgttc    960

tattctcttg caagaaaata catttgtaga acaagtagta aatgaaaaag tcaaacactt   1020

agaagatacc ttaaaagaac ttgaatctca acacagtatc ttaaaagatg aggtaactta   1080

tatgaataat cttaagttaa aacttgaaat ggatgctcaa catataaagg atgagttttt   1140

tcatgaacgg gaagacttag agtttaaaat taatgaatta ttactagcta aagaagaaca   1200

gggctgtgta attgaaaaat taaaatctga gctagcaggt ttaaataaac agttttgcta   1260

tactgtagaa cagcataaca gagaagtaca gagtcttaag gaacaacatc aaaaagaaat   1320

atcagaacta aatgagacat ttttgtcaga ttcagaaaaa gaaaaattaa cattaatgtt   1380

tgaaatacag ggtcttaagg aacagtgtga aaacctacag caagaaaagc aagaagcaat   1440

tttaaattat gagagtttac gagagattat ggaaatttta caaacagaac tgggggaatc   1500

tgctggaaaa ataagtcaag agttcgaatc aatgaagcaa cagcaagcat ctgatgttca   1560

tgaactgcag cagaagctca gaactgcttt tactgaaaaa gatgcccttc tcgaaactgt   1620

gaatcgcctc cagggagaaa atgaaaagtt actatctcaa caagaattgg taccagaact   1680

tgaaaatacc ataaagaacc ttcaagaaaa gaatggagta tacttactta gtctcagtca   1740

aagagatacc atgttaaaag aattagaagg aaagataaat tctcttactg aggaaaaaga   1800

tgattttata aataaactga aaaattccca tgaagaaatg gataatttcc ataagaaatg   1860

tgaaagggaa gaaagattga ttcttgaact tgggaagaaa gtagagcaaa caatccagta   1920

caacagtgaa ctagaacaaa aggtaaatga attaacagga ggactagagg agactttaaa   1980

agaaaaggat caaaatgacc aaaaactaga aaaacttatg gttcaaatga aagttctctc   2040

tgaagacaaa gaagtattgt cagctgaagt gaagtctctt tatgaggaaa acaataaact   2100

cagttcagaa aaaaaacagt tgagtaggga tttggaggtt tttttgtctc aaaaagaaga   2160

tgttatcctt aaagaacata ttactcaatt agaaaagaaa cttcagttaa tggttgaaga   2220

gcaagataat ttaaataaac tgcttgaaaa tgagcaagtt cagaagttat ttgttaaaac   2280

tcagttgtat ggttttctta aagaaatggg atcagaagtt tcagaagaca gtgaagagaa   2340

agatgttgtt aatgtcctac aggcagtcgg tgaatccttg gcaaaaataa atgaggaaaa   2400

atgcaacctg gcttttcagc gtgatgaaaa agtattagag ttagaaaaag agattaagtg   2460

ccttcaagaa gagagtgtag ttcagtgtga agaacttaag tctttattga gagactatga   2520

gcaagagaaa gttctcttaa ggaaagagtt agaagaaata cagtcagaaa aagaggccct   2580

gcagtctgat cttctagaaa tgaagaatgc taatgaaaaa acaaggcttg aaaatcagaa   2640

tcttttaatt caagttgaag aagtatctca aacatgtagc aaaagtgaaa tccataatga   2700

aaaagaaaaa tgttttataa aggaacatga aaacctaaag ccactactag aacaaaaaga   2760

attacgagat aggagagcag agttgatact attaaaggat tccttagcaa aatcaccttc   2820

tgtaaaaaat gatcctctgt cttcagtaaa agagttggaa gaaaaaatag aaaatctgga   2880

aaaagaatgc aaagaaaagg aggagaaaat aaataagata aaattagttg ccgtaaaggc   2940

aaagaaagaa ctagattcca gcagaaaaga gacccagact gtgaaggaag aacttgaatc   3000

tcttcgatca gaaaaggacc agttatctgc ttccatgaga gatctcattc aaggagcaga   3060

aagctataag aatcttttat tagaatatga aaagcagtca gagcaactgg atgtggaaaa   3120

agaacgtgct aataattttg agcatcgtat tgaagacctt acaagacaat taagaaattc   3180

gactttgcag tgtgaaacaa taaattctga taatgaagat ctcctggctc gtattgagac   3240

attacagtct aatgccaaat tattagaagt acagatttta gaagtccaga gagccaaagc   3300

aatggtagac aaagaattag aagctgaaaa acttcagaaa gaacagaaga taaaggaaca   3360

tgccactact gtaaatgaac ttgaagaact tcaggtacaa cttcaaaagg aaaagaaaca   3420

gcttcagaaa accatgcaag aattagagct ggttaaaaag gatgcccaac aaaccacatt   3480

gatgaatatg gaaatagctg attatgaacg tttgatgaaa gaactaaatc aaaagttaac   3540

taataaaaac aacaagatag aagatttgga gcaagaaata aaaattcaaa aacagaaaca   3600

agaaacccta caagaagaaa taacttcatt acagtcttca gtacaacaat atgaagaaaa   3660

aaacaccaaa atcaagcaat tgcttgtgaa aaccaaaaag gaactggcag attcaaagca   3720

agcagaaact gatcacttaa tacttcaagc atctttaaaa ggtgagctgg aggcaagcca   3780

gcagcaagta gaagtctata aaatacagct ggctgaaata acatcagaga agcacaaaat   3840

ccacgagcac ctgaaaacct ctgcggaaca gcaccagcgt acgctaagtg cataccagca   3900

gagagtgaca gcactacagg aagagtgccg tgctgccaag gcagaacaag ctactgtaac   3960

ctctgaattc gagagctaca aagtccgagt tcataatgtt ctaaaacaac agaaaaataa   4020

atctatgtct caggctgaaa ctgagggcgc taaacaagaa agggaacatc tggaaatgct   4080

gattgaccag ctaaaaatca aattacaaga tagccaaaat aacttacaga ttaatgtatc   4140

tgaacttcaa acattgcagt ctgaacatga tacactgcta gaaaggcaca acaagatgct   4200

gcaggaaact gtgtccaaag aggcggaact ccgggaaaaa ttgtgttcaa tacagtcaga   4260

gaacatgatg atgaaatctg aacatacaca gactgtgagt cagctaacat cccagaacga   4320

ggtccttcga aatagcttcc gagatcaagt gcgacatttg caggaagaac acagaaagac   4380

agtggagaca ttacagcagc agctctccaa gatggaagca cagctcttcc agcttaagaa   4440

tgaaccgacc acaagaagcc cagtttcctc tcaacaatct ttgaagaacc ttcgagaaag   4500

gagaaacaca gacctcccgc ttctagacat gcacactgta acccgggaag agggagaagg   4560

catggagaca actgatacgg agtctgtgtc ttccgccagc acatacacac agtctttaga   4620

gcagctgctt aactctcccg aaactaaact tgagcctcca ttatggcatg ctgaatttac   4680

caaagaagaa ttggttcaga agctcagttc caccacaaaa agtgcagatc acttaaacgg   4740

cctgcttcgg gaaacagaag caaccaatgc aattcttatg gagcaaatta agcttctcaa   4800

aagtgaaata agaagattgg aaaggaatca agagcgagag aagtctgcag ctaacctgga   4860

atacttgaag aacgtcttgc tgcagttcat tttcttgaaa ccaggtagtg aaagagagag   4920

acttcttcct gttataaata cgatgttgca gctcagccct gaagaaaagg gaaaacttgc   4980

tgcggttgct caaggtgagg aagaaaatgc ttcccgttct tctggatggg catcctatct   5040

tcatagttgg tctggacttc gataggttga tggaaggaat atttttatta accaaataga   5100

atctatttac aaaaatggtt cacgtatatt accacaattc ttttgtcaaa aagtgtgtat   5160

atatgtttgc atctacatat atttgtacat ctatatgaca gatgtatttt aaaagtttca   5220

tcttgaagta aaagtacaac agcttgaagt gttgatagca ggccacagcc ctctaactca   5280

tgtgatttcc catgcatgct gccagaataa aaccaccagg aatgaattca ctccccactt   5340

ctctggaacc tcaggacccg cccatttctc ggcagtactg tgaattttga agttaaacta   5400

aattttggta ccataccaac tggaatttag gctttaaaaa taatgtttca aggccaggtg   5460

tggtgattca tgcctgaaat cccactactt tgggaggctg aggctggaga attgcttgag   5520

gctagtgagc tgtgactccc actgcactcc agctcgggga acagagcgag accttgtctc   5580

taaaaataat agtaataaaa taaaaataac gttttatgac tatttattgc aaggtcagag   5640

ttacagattg ttataaattg ttgagaaatt tttgtgatta gaatatgaag gaaaaagctt   5700

tgttggtaaa agtgacatgt taaggggcta tgaagtaaat atgctgcagt taattatgct   5760

aagttaaaat acagtttagt tatttgcttt aaaataaact cttctttttt tctttaaagt   5820

atactatctc aaaactcatt atgttgtcag agccctagag ctggctagtg taacactgac   5880

tatgagtagg tgggcccaca cttgagttga ggtgatttca tggtgtcttt ccaggctctt   5940

gatagggtgt cactgcatgc aagccatgaa tctgttttga gaatcctctc cattttccca   6000

aataaaaacc tatcacaaca gtgactatat cactcagcat tggatctaaa tataaaagtg   6060

gtgctttcag tgtttttggc agatagtgtt ccataagctt tccatcagaa gggattttag   6120

acaccttaga ggtccgtgct acatcgtcac agttcctccg aataacctta ggtggtagtg   6180

ttacttgcct ttgacacctc tgcatatgtt ttaatgacta gatccaaact gtgttgttct   6240

taaatcaaaa attggataat ttgtaatatt tatgtgttaa tcacacagta tgctctctga   6300

agttctctta agccttcagt ttatactctt aatttaattt tctttctgag ctggagaact   6360

ggctttgcac tttggttaca cagaacattg gtttccaatt cagtttaact gaaatttgct   6420

gctgatatgt tgagtttgtt ctttaaaaaa tagctcatat atctcatctt tcctcctgtc   6480

ttagaagaac agacctaact agtgaatgta ttaatgaaaa tgcatctatt tcagagctga   6540

catgaagagt ttagtttttt tactttataa actgtgaata tgagtatgcc agctgcatac   6600

gatgtaacta atcatattta aatatatttc actttctctt tgactttaga ccttttgaag   6660

tctgtataaa cttgttttga aatatagtct ctgcttacga atgtcataac aaaataattt   6720

tttgcatgat aaaaaattac tttgattaca aaaggcatat tctttcatgg tttctgcaat   6780

gagaggaagt gtaatgatta ttttaatatt tctattaaat atgtttaact gta          6833


<210>  590
<211>  1583
<212>  PRT
<213>  Homosapiens

<400>  590

Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys Met Gly Asp Ala His 
1               5                   10                  15      


Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val Lys Glu Ile Glu Asn 
            20                  25                  30          


Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys Tyr Ser Glu Asp Lys 
        35                  40                  45              


Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met Asn Thr Gln Leu Glu 
    50                  55                  60                  


Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser Glu Asp Asn Val Lys 
65                  70                  75                  80  


Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro Gly Phe Glu Glu Gln 
                85                  90                  95      


Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr Thr Asp Glu Lys Lys 
            100                 105                 110         


Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu Ala Asn Ser Gln His 
        115                 120                 125             


Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu Leu Leu Gln Leu Lys 
    130                 135                 140                 


Ala Ile His Gln Glu Glu Val Lys Glu Leu Met Cys Gln Ile Glu Ala 
145                 150                 155                 160 


Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys Leu Asn Glu Leu Lys 
                165                 170                 175     


Glu Asn Leu Val Lys Gln Cys Glu Ala Ser Glu Lys Asn Ile Gln Lys 
            180                 185                 190         


Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys Ala Thr Ser Asn Ala 
        195                 200                 205             


Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu Gln Glu Asn Thr Phe 
    210                 215                 220                 


Val Glu Gln Val Val Asn Glu Lys Val Lys His Leu Glu Asp Thr Leu 
225                 230                 235                 240 


Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys Asp Glu Val Thr Tyr 
                245                 250                 255     


Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp Ala Gln His Ile Lys 
            260                 265                 270         


Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu Phe Lys Ile Asn Glu 
        275                 280                 285             


Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val Ile Glu Lys Leu Lys 
    290                 295                 300                 


Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys Tyr Thr Val Glu Gln 
305                 310                 315                 320 


His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln His Gln Lys Glu Ile 
                325                 330                 335     


Ser Glu Leu Asn Glu Thr Phe Leu Ser Asp Ser Glu Lys Glu Lys Leu 
            340                 345                 350         


Thr Leu Met Phe Glu Ile Gln Gly Leu Lys Glu Gln Cys Glu Asn Leu 
        355                 360                 365             


Gln Gln Glu Lys Gln Glu Ala Ile Leu Asn Tyr Glu Ser Leu Arg Glu 
    370                 375                 380                 


Ile Met Glu Ile Leu Gln Thr Glu Leu Gly Glu Ser Ala Gly Lys Ile 
385                 390                 395                 400 


Ser Gln Glu Phe Glu Ser Met Lys Gln Gln Gln Ala Ser Asp Val His 
                405                 410                 415     


Glu Leu Gln Gln Lys Leu Arg Thr Ala Phe Thr Glu Lys Asp Ala Leu 
            420                 425                 430         


Leu Glu Thr Val Asn Arg Leu Gln Gly Glu Asn Glu Lys Leu Leu Ser 
        435                 440                 445             


Gln Gln Glu Leu Val Pro Glu Leu Glu Asn Thr Ile Lys Asn Leu Gln 
    450                 455                 460                 


Glu Lys Asn Gly Val Tyr Leu Leu Ser Leu Ser Gln Arg Asp Thr Met 
465                 470                 475                 480 


Leu Lys Glu Leu Glu Gly Lys Ile Asn Ser Leu Thr Glu Glu Lys Asp 
                485                 490                 495     


Asp Phe Ile Asn Lys Leu Lys Asn Ser His Glu Glu Met Asp Asn Phe 
            500                 505                 510         


His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile Leu Glu Leu Gly Lys 
        515                 520                 525             


Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu Leu Glu Gln Lys Val 
    530                 535                 540                 


Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu Lys Glu Lys Asp Gln 
545                 550                 555                 560 


Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln Met Lys Val Leu Ser 
                565                 570                 575     


Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys Ser Leu Tyr Glu Glu 
            580                 585                 590         


Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu Ser Arg Asp Leu Glu 
        595                 600                 605             


Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu Lys Glu His Ile Thr 
    610                 615                 620                 


Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu Glu Gln Asp Asn Leu 
625                 630                 635                 640 


Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys Leu Phe Val Lys Thr 
                645                 650                 655     


Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser Glu Val Ser Glu Asp 
            660                 665                 670         


Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln Ala Val Gly Glu Ser 
        675                 680                 685             


Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu Ala Phe Gln Arg Asp 
    690                 695                 700                 


Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys Cys Leu Gln Glu Glu 
705                 710                 715                 720 


Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu Leu Arg Asp Tyr Glu 
                725                 730                 735     


Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu Glu Ile Gln Ser Glu 
            740                 745                 750         


Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met Lys Asn Ala Asn Glu 
        755                 760                 765             


Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile Gln Val Glu Glu Val 
    770                 775                 780                 


Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn Glu Lys Glu Lys Cys 
785                 790                 795                 800 


Phe Ile Lys Glu His Glu Asn Leu Lys Pro Leu Leu Glu Gln Lys Glu 
                805                 810                 815     


Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu Lys Asp Ser Leu Ala 
            820                 825                 830         


Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser Ser Val Lys Glu Leu 
        835                 840                 845             


Glu Glu Lys Ile Glu Asn Leu Glu Lys Glu Cys Lys Glu Lys Glu Glu 
    850                 855                 860                 


Lys Ile Asn Lys Ile Lys Leu Val Ala Val Lys Ala Lys Lys Glu Leu 
865                 870                 875                 880 


Asp Ser Ser Arg Lys Glu Thr Gln Thr Val Lys Glu Glu Leu Glu Ser 
                885                 890                 895     


Leu Arg Ser Glu Lys Asp Gln Leu Ser Ala Ser Met Arg Asp Leu Ile 
            900                 905                 910         


Gln Gly Ala Glu Ser Tyr Lys Asn Leu Leu Leu Glu Tyr Glu Lys Gln 
        915                 920                 925             


Ser Glu Gln Leu Asp Val Glu Lys Glu Arg Ala Asn Asn Phe Glu His 
    930                 935                 940                 


Arg Ile Glu Asp Leu Thr Arg Gln Leu Arg Asn Ser Thr Leu Gln Cys 
945                 950                 955                 960 


Glu Thr Ile Asn Ser Asp Asn Glu Asp Leu Leu Ala Arg Ile Glu Thr 
                965                 970                 975     


Leu Gln Ser Asn Ala Lys Leu Leu Glu Val Gln Ile Leu Glu Val Gln 
            980                 985                 990         


Arg Ala Lys Ala Met Val Asp Lys  Glu Leu Glu Ala Glu  Lys Leu Gln 
        995                 1000                 1005             


Lys Glu  Gln Lys Ile Lys Glu  His Ala Thr Thr Val  Asn Glu Leu 
    1010                 1015                 1020             


Glu Glu  Leu Gln Val Gln Leu  Gln Lys Glu Lys Lys  Gln Leu Gln 
    1025                 1030                 1035             


Lys Thr  Met Gln Glu Leu Glu  Leu Val Lys Lys Asp  Ala Gln Gln 
    1040                 1045                 1050             


Thr Thr  Leu Met Asn Met Glu  Ile Ala Asp Tyr Glu  Arg Leu Met 
    1055                 1060                 1065             


Lys Glu  Leu Asn Gln Lys Leu  Thr Asn Lys Asn Asn  Lys Ile Glu 
    1070                 1075                 1080             


Asp Leu  Glu Gln Glu Ile Lys  Ile Gln Lys Gln Lys  Gln Glu Thr 
    1085                 1090                 1095             


Leu Gln  Glu Glu Ile Thr Ser  Leu Gln Ser Ser Val  Gln Gln Tyr 
    1100                 1105                 1110             


Glu Glu  Lys Asn Thr Lys Ile  Lys Gln Leu Leu Val  Lys Thr Lys 
    1115                 1120                 1125             


Lys Glu  Leu Ala Asp Ser Lys  Gln Ala Glu Thr Asp  His Leu Ile 
    1130                 1135                 1140             


Leu Gln  Ala Ser Leu Lys Gly  Glu Leu Glu Ala Ser  Gln Gln Gln 
    1145                 1150                 1155             


Val Glu  Val Tyr Lys Ile Gln  Leu Ala Glu Ile Thr  Ser Glu Lys 
    1160                 1165                 1170             


His Lys  Ile His Glu His Leu  Lys Thr Ser Ala Glu  Gln His Gln 
    1175                 1180                 1185             


Arg Thr  Leu Ser Ala Tyr Gln  Gln Arg Val Thr Ala  Leu Gln Glu 
    1190                 1195                 1200             


Glu Cys  Arg Ala Ala Lys Ala  Glu Gln Ala Thr Val  Thr Ser Glu 
    1205                 1210                 1215             


Phe Glu  Ser Tyr Lys Val Arg  Val His Asn Val Leu  Lys Gln Gln 
    1220                 1225                 1230             


Lys Asn  Lys Ser Met Ser Gln  Ala Glu Thr Glu Gly  Ala Lys Gln 
    1235                 1240                 1245             


Glu Arg  Glu His Leu Glu Met  Leu Ile Asp Gln Leu  Lys Ile Lys 
    1250                 1255                 1260             


Leu Gln  Asp Ser Gln Asn Asn  Leu Gln Ile Asn Val  Ser Glu Leu 
    1265                 1270                 1275             


Gln Thr  Leu Gln Ser Glu His  Asp Thr Leu Leu Glu  Arg His Asn 
    1280                 1285                 1290             


Lys Met  Leu Gln Glu Thr Val  Ser Lys Glu Ala Glu  Leu Arg Glu 
    1295                 1300                 1305             


Lys Leu  Cys Ser Ile Gln Ser  Glu Asn Met Met Met  Lys Ser Glu 
    1310                 1315                 1320             


His Thr  Gln Thr Val Ser Gln  Leu Thr Ser Gln Asn  Glu Val Leu 
    1325                 1330                 1335             


Arg Asn  Ser Phe Arg Asp Gln  Val Arg His Leu Gln  Glu Glu His 
    1340                 1345                 1350             


Arg Lys  Thr Val Glu Thr Leu  Gln Gln Gln Leu Ser  Lys Met Glu 
    1355                 1360                 1365             


Ala Gln  Leu Phe Gln Leu Lys  Asn Glu Pro Thr Thr  Arg Ser Pro 
    1370                 1375                 1380             


Val Ser  Ser Gln Gln Ser Leu  Lys Asn Leu Arg Glu  Arg Arg Asn 
    1385                 1390                 1395             


Thr Asp  Leu Pro Leu Leu Asp  Met His Thr Val Thr  Arg Glu Glu 
    1400                 1405                 1410             


Gly Glu  Gly Met Glu Thr Thr  Asp Thr Glu Ser Val  Ser Ser Ala 
    1415                 1420                 1425             


Ser Thr  Tyr Thr Gln Ser Leu  Glu Gln Leu Leu Asn  Ser Pro Glu 
    1430                 1435                 1440             


Thr Lys  Leu Glu Pro Pro Leu  Trp His Ala Glu Phe  Thr Lys Glu 
    1445                 1450                 1455             


Glu Leu  Val Gln Lys Leu Ser  Ser Thr Thr Lys Ser  Ala Asp His 
    1460                 1465                 1470             


Leu Asn  Gly Leu Leu Arg Glu  Thr Glu Ala Thr Asn  Ala Ile Leu 
    1475                 1480                 1485             


Met Glu  Gln Ile Lys Leu Leu  Lys Ser Glu Ile Arg  Arg Leu Glu 
    1490                 1495                 1500             


Arg Asn  Gln Glu Arg Glu Lys  Ser Ala Ala Asn Leu  Glu Tyr Leu 
    1505                 1510                 1515             


Lys Asn  Val Leu Leu Gln Phe  Ile Phe Leu Lys Pro  Gly Ser Glu 
    1520                 1525                 1530             


Arg Glu  Arg Leu Leu Pro Val  Ile Asn Thr Met Leu  Gln Leu Ser 
    1535                 1540                 1545             


Pro Glu  Glu Lys Gly Lys Leu  Ala Ala Val Ala Gln  Gly Glu Glu 
    1550                 1555                 1560             


Glu Asn  Ala Ser Arg Ser Ser  Gly Trp Ala Ser Tyr  Leu His Ser 
    1565                 1570                 1575             


Trp Ser  Gly Leu Arg 
    1580             


<210>  591
<211>  6918
<212>  DNA
<213>  Homosapiens

<400>  591
ctttgacctg cagtagagcc tacgtcagag gctggcgcaa acagaagtgc agcggtggcg     60

gcggctggtt gcgggccggc ggcgggctgg cggagatgga ggatcttgtt caagatgggg    120

tggcttcacc agctacccct gggaccggga aatctaagct ggaaacattg cccaaagaag    180

acctcatcaa gtttgccaag aaacagatga tgctaataca gaaagctaaa tcaaggtgta    240

cagaattgga gaaagaaatt gaagaactca gatcaaaacc tgttactgaa ggaactggtg    300

atattattaa ggcattaact gaacgtctgg atgctcttct tctggaaaaa gcagagactg    360

agcaacagtg tctttctctg aaaaaggaaa atataaaaat gaagcaagag gttgaggatt    420

ctgtaacaaa gatgggagat gcacataagg agttggaaca atcacatata aactatgtga    480

aagaaattga aaatttgaaa aatgagttga tggcagtacg ttccaaatac agtgaagaca    540

aagctaactt acaaaagcag ctggaagaag caatgaatac gcaattagaa ctttcagaac    600

aacttaaatt tcagaacaac tctgaagata atgttaaaaa actacaagaa gagattgaga    660

aaattaggcc aggctttgag gagcaaattt tatatctgca aaagcaatta gacgctacca    720

ctgatgaaaa gaaggaaaca gttactcaac tccaaaatat cattgaggct aattctcagc    780

attaccaaaa aaatattaat agtttgcagg aagagctttt acagttgaaa gctatacacc    840

aagaagaggt gaaagagttg atgtgccaga ttgaagcatc agctaaggaa catgaagcag    900

agataaataa gttgaacgag ctaaaagaga acttagtaaa acaatgtgag gcaagtgaaa    960

agaacatcca gaagaaatat gaatgtgagt tagaaaattt aaggaaagcc acctcaaatg   1020

caaaccaaga caatcagata tgttctattc tcttgcaaga aaatacattt gtagaacaag   1080

tagtaaatga aaaagtcaaa cacttagaag ataccttaaa agaacttgaa tctcaacaca   1140

gtatcttaaa agatgaggta acttatatga ataatcttaa gttaaaactt gaaatggatg   1200

ctcaacatat aaaggatgag ttttttcatg aacgggaaga cttagagttt aaaattaatg   1260

aattattact agctaaagaa gaacagggct gtgtaattga aaaattaaaa tctgagctag   1320

caggtttaaa taaacagttt tgctatactg tagaacagca taacagagaa gtacagagtc   1380

ttaaggaaca acatcaaaaa gaaatatcag aactaaatga gacatttttg tcagattcag   1440

aaaaagaaaa attaacatta atgtttgaaa tacagggtct taaggaacag tgtgaaaacc   1500

tacagcaaga aaagcaagaa gcaattttaa attatgagag tttacgagag attatggaaa   1560

ttttacaaac agaactgggg gaatctgctg gaaaaataag tcaagagttc gaatcaatga   1620

agcaacagca agcatctgat gttcatgaac tgcagcagaa gctcagaact gcttttactg   1680

aaaaagatgc ccttctcgaa actgtgaatc gcctccaggg agaaaatgaa aagttactat   1740

ctcaacaaga attggtacca gaacttgaaa ataccataaa gaaccttcaa gaaaagaatg   1800

gagtatactt acttagtctc agtcaaagag ataccatgtt aaaagaatta gaaggaaaga   1860

taaattctct tactgaggaa aaagatgatt ttataaataa actgaaaaat tcccatgaag   1920

aaatggataa tttccataag aaatgtgaaa gggaagaaag attgattctt gaacttggga   1980

agaaagtaga gcaaacaatc cagtacaaca gtgaactaga acaaaaggta aatgaattaa   2040

caggaggact agaggagact ttaaaagaaa aggatcaaaa tgaccaaaaa ctagaaaaac   2100

ttatggttca aatgaaagtt ctctctgaag acaaagaagt attgtcagct gaagtgaagt   2160

ctctttatga ggaaaacaat aaactcagtt cagaaaaaaa acagttgagt agggatttgg   2220

aggttttttt gtctcaaaaa gaagatgtta tccttaaaga acatattact caattagaaa   2280

agaaacttca gttaatggtt gaagagcaag ataatttaaa taaactgctt gaaaatgagc   2340

aagttcagaa gttatttgtt aaaactcagt tgtatggttt tcttaaagaa atgggatcag   2400

aagtttcaga agacagtgaa gagaaagatg ttgttaatgt cctacaggca gtcggtgaat   2460

ccttggcaaa aataaatgag gaaaaatgca acctggcttt tcagcgtgat gaaaaagtat   2520

tagagttaga aaaagagatt aagtgccttc aagaagagag tgtagttcag tgtgaagaac   2580

ttaagtcttt attgagagac tatgagcaag agaaagttct cttaaggaaa gagttagaag   2640

aaatacagtc agaaaaagag gccctgcagt ctgatcttct agaaatgaag aatgctaatg   2700

aaaaaacaag gcttgaaaat cagaatcttt taattcaagt tgaagaagta tctcaaacat   2760

gtagcaaaag tgaaatccat aatgaaaaag aaaaatgttt tataaaggaa catgaaaacc   2820

taaagccact actagaacaa aaagaattac gagataggag agcagagttg atactattaa   2880

aggattcctt agcaaaatca ccttctgtaa aaaatgatcc tctgtcttca gtaaaagagt   2940

tggaagaaaa aatagaaaat ctggaaaaag aatgcaaaga aaaggaggag aaaataaata   3000

agataaaatt agttgccgta aaggcaaaga aagaactaga ttccagcaga aaagagaccc   3060

agactgtgaa ggaagaactt gaatctcttc gatcagaaaa ggaccagtta tctgcttcca   3120

tgagagatct cattcaagga gcagaaagct ataagaatct tttattagaa tatgaaaagc   3180

agtcagagca actggatgtg gaaaaagaac gtgctaataa ttttgagcat cgtattgaag   3240

accttacaag acaattaaga aattcgactt tgcagtgtga aacaataaat tctgataatg   3300

aagatctcct ggctcgtatt gagacattac agtctaatgc caaattatta gaagtacaga   3360

ttttagaagt ccagagagcc aaagcaatgg tagacaaaga attagaagct gaaaaacttc   3420

agaaagaaca gaagataaag gaacatgcca ctactgtaaa tgaacttgaa gaacttcagg   3480

tacaacttca aaaggaaaag aaacagcttc agaaaaccat gcaagaatta gagctggtta   3540

aaaaggatgc ccaacaaacc acattgatga atatggaaat agctgattat gaacgtttga   3600

tgaaagaact aaatcaaaag ttaactaata aaaacaacaa gatagaagat ttggagcaag   3660

aaataaaaat tcaaaaacag aaacaagaaa ccctacaaga agaaataact tcattacagt   3720

cttcagtaca acaatatgaa gaaaaaaaca ccaaaatcaa gcaattgctt gtgaaaacca   3780

aaaaggaact ggcagattca aagcaagcag aaactgatca cttaatactt caagcatctt   3840

taaaaggtga gctggaggca agccagcagc aagtagaagt ctataaaata cagctggctg   3900

aaataacatc agagaagcac aaaatccacg agcacctgaa aacctctgcg gaacagcacc   3960

agcgtacgct aagtgcatac cagcagagag tgacagcact acaggaagag tgccgtgctg   4020

ccaaggcaga acaagctact gtaacctctg aattcgagag ctacaaagtc cgagttcata   4080

atgttctaaa acaacagaaa aataaatcta tgtctcaggc tgaaactgag ggcgctaaac   4140

aagaaaggga acatctggaa atgctgattg accagctaaa aatcaaatta caagatagcc   4200

aaaataactt acagattaat gtatctgaac ttcaaacatt gcagtctgaa catgatacac   4260

tgctagaaag gcacaacaag atgctgcagg aaactgtgtc caaagaggcg gaactccggg   4320

aaaaattgtg ttcaatacag tcagagaaca tgatgatgaa atctgaacat acacagactg   4380

tgagtcagct aacatcccag aacgaggtcc ttcgaaatag cttccgagat caagtgcgac   4440

atttgcagga agaacacaga aagacagtgg agacattaca gcagcagctc tccaagatgg   4500

aagcacagct cttccagctt aagaatgaac cgaccacaag aagcccagtt tcctctcaac   4560

aatctttgaa gaaccttcga gaaaggagaa acacagacct cccgcttcta gacatgcaca   4620

ctgtaacccg ggaagaggga gaaggcatgg agacaactga tacggagtct gtgtcttccg   4680

ccagcacata cacacagtct ttagagcagc tgcttaactc tcccgaaact aaacttgagc   4740

ctccattatg gcatgctgaa tttaccaaag aagaattggt tcagaagctc agttccacca   4800

caaaaagtgc agatcactta aacggcctgc ttcgggaaac agaagcaacc aatgcaattc   4860

ttatggagca aattaagctt ctcaaaagtg aaataagaag attggaaagg aatcaagagc   4920

gagagaagtc tgcagctaac ctggaatact tgaagaacgt cttgctgcag ttcattttct   4980

tgaaaccagg tagtgaaaga gagagacttc ttcctgttat aaatacgatg ttgcagctca   5040

gccctgaaga aaagggaaaa cttgctgcgg ttgctcaagg tgaggaagaa aatgcttccc   5100

gttcttctgg atgggcatcc tatcttcata gttggtctgg acttcgatag gttgatggaa   5160

ggaatatttt tattaaccaa atagaatcta tttacaaaaa tggttcacgt atattaccac   5220

aattcttttg tcaaaaagtg tgtatatatg tttgcatcta catatatttg tacatctata   5280

tgacagatgt attttaaaag tttcatcttg aagtaaaagt acaacagctt gaagtgttga   5340

tagcaggcca cagccctcta actcatgtga tttcccatgc atgctgccag aataaaacca   5400

ccaggaatga attcactccc cacttctctg gaacctcagg acccgcccat ttctcggcag   5460

tactgtgaat tttgaagtta aactaaattt tggtaccata ccaactggaa tttaggcttt   5520

aaaaataatg tttcaaggcc aggtgtggtg attcatgcct gaaatcccac tactttggga   5580

ggctgaggct ggagaattgc ttgaggctag tgagctgtga ctcccactgc actccagctc   5640

ggggaacaga gcgagacctt gtctctaaaa ataatagtaa taaaataaaa ataacgtttt   5700

atgactattt attgcaaggt cagagttaca gattgttata aattgttgag aaatttttgt   5760

gattagaata tgaaggaaaa agctttgttg gtaaaagtga catgttaagg ggctatgaag   5820

taaatatgct gcagttaatt atgctaagtt aaaatacagt ttagttattt gctttaaaat   5880

aaactcttct ttttttcttt aaagtatact atctcaaaac tcattatgtt gtcagagccc   5940

tagagctggc tagtgtaaca ctgactatga gtaggtgggc ccacacttga gttgaggtga   6000

tttcatggtg tctttccagg ctcttgatag ggtgtcactg catgcaagcc atgaatctgt   6060

tttgagaatc ctctccattt tcccaaataa aaacctatca caacagtgac tatatcactc   6120

agcattggat ctaaatataa aagtggtgct ttcagtgttt ttggcagata gtgttccata   6180

agctttccat cagaagggat tttagacacc ttagaggtcc gtgctacatc gtcacagttc   6240

ctccgaataa ccttaggtgg tagtgttact tgcctttgac acctctgcat atgttttaat   6300

gactagatcc aaactgtgtt gttcttaaat caaaaattgg ataatttgta atatttatgt   6360

gttaatcaca cagtatgctc tctgaagttc tcttaagcct tcagtttata ctcttaattt   6420

aattttcttt ctgagctgga gaactggctt tgcactttgg ttacacagaa cattggtttc   6480

caattcagtt taactgaaat ttgctgctga tatgttgagt ttgttcttta aaaaatagct   6540

catatatctc atctttcctc ctgtcttaga agaacagacc taactagtga atgtattaat   6600

gaaaatgcat ctatttcaga gctgacatga agagtttagt ttttttactt tataaactgt   6660

gaatatgagt atgccagctg catacgatgt aactaatcat atttaaatat atttcacttt   6720

ctctttgact ttagaccttt tgaagtctgt ataaacttgt tttgaaatat agtctctgct   6780

tacgaatgtc ataacaaaat aattttttgc atgataaaaa attactttga ttacaaaagg   6840

catattcttt catggtttct gcaatgagag gaagtgtaat gattatttta atatttctat   6900

taaatatgtt taactgta                                                 6918


<210>  592
<211>  1684
<212>  PRT
<213>  Homosapiens

<400>  592

Met Glu Asp Leu Val Gln Asp Gly Val Ala Ser Pro Ala Thr Pro Gly 
1               5                   10                  15      


Thr Gly Lys Ser Lys Leu Glu Thr Leu Pro Lys Glu Asp Leu Ile Lys 
            20                  25                  30          


Phe Ala Lys Lys Gln Met Met Leu Ile Gln Lys Ala Lys Ser Arg Cys 
        35                  40                  45              


Thr Glu Leu Glu Lys Glu Ile Glu Glu Leu Arg Ser Lys Pro Val Thr 
    50                  55                  60                  


Glu Gly Thr Gly Asp Ile Ile Lys Ala Leu Thr Glu Arg Leu Asp Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Ala Glu Thr Glu Gln Gln Cys Leu Ser Leu Lys 
                85                  90                  95      


Lys Glu Asn Ile Lys Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys 
            100                 105                 110         


Met Gly Asp Ala His Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val 
        115                 120                 125             


Lys Glu Ile Glu Asn Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys 
    130                 135                 140                 


Tyr Ser Glu Asp Lys Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met 
145                 150                 155                 160 


Asn Thr Gln Leu Glu Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser 
                165                 170                 175     


Glu Asp Asn Val Lys Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro 
            180                 185                 190         


Gly Phe Glu Glu Gln Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr 
        195                 200                 205             


Thr Asp Glu Lys Lys Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu 
    210                 215                 220                 


Ala Asn Ser Gln His Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu 
225                 230                 235                 240 


Leu Leu Gln Leu Lys Ala Ile His Gln Glu Glu Val Lys Glu Leu Met 
                245                 250                 255     


Cys Gln Ile Glu Ala Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys 
            260                 265                 270         


Leu Asn Glu Leu Lys Glu Asn Leu Val Lys Gln Cys Glu Ala Ser Glu 
        275                 280                 285             


Lys Asn Ile Gln Lys Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys 
    290                 295                 300                 


Ala Thr Ser Asn Ala Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu 
305                 310                 315                 320 


Gln Glu Asn Thr Phe Val Glu Gln Val Val Asn Glu Lys Val Lys His 
                325                 330                 335     


Leu Glu Asp Thr Leu Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys 
            340                 345                 350         


Asp Glu Val Thr Tyr Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp 
        355                 360                 365             


Ala Gln His Ile Lys Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu 
    370                 375                 380                 


Phe Lys Ile Asn Glu Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val 
385                 390                 395                 400 


Ile Glu Lys Leu Lys Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys 
                405                 410                 415     


Tyr Thr Val Glu Gln His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln 
            420                 425                 430         


His Gln Lys Glu Ile Ser Glu Leu Asn Glu Thr Phe Leu Ser Asp Ser 
        435                 440                 445             


Glu Lys Glu Lys Leu Thr Leu Met Phe Glu Ile Gln Gly Leu Lys Glu 
    450                 455                 460                 


Gln Cys Glu Asn Leu Gln Gln Glu Lys Gln Glu Ala Ile Leu Asn Tyr 
465                 470                 475                 480 


Glu Ser Leu Arg Glu Ile Met Glu Ile Leu Gln Thr Glu Leu Gly Glu 
                485                 490                 495     


Ser Ala Gly Lys Ile Ser Gln Glu Phe Glu Ser Met Lys Gln Gln Gln 
            500                 505                 510         


Ala Ser Asp Val His Glu Leu Gln Gln Lys Leu Arg Thr Ala Phe Thr 
        515                 520                 525             


Glu Lys Asp Ala Leu Leu Glu Thr Val Asn Arg Leu Gln Gly Glu Asn 
    530                 535                 540                 


Glu Lys Leu Leu Ser Gln Gln Glu Leu Val Pro Glu Leu Glu Asn Thr 
545                 550                 555                 560 


Ile Lys Asn Leu Gln Glu Lys Asn Gly Val Tyr Leu Leu Ser Leu Ser 
                565                 570                 575     


Gln Arg Asp Thr Met Leu Lys Glu Leu Glu Gly Lys Ile Asn Ser Leu 
            580                 585                 590         


Thr Glu Glu Lys Asp Asp Phe Ile Asn Lys Leu Lys Asn Ser His Glu 
        595                 600                 605             


Glu Met Asp Asn Phe His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile 
    610                 615                 620                 


Leu Glu Leu Gly Lys Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu 
625                 630                 635                 640 


Leu Glu Gln Lys Val Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu 
                645                 650                 655     


Lys Glu Lys Asp Gln Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln 
            660                 665                 670         


Met Lys Val Leu Ser Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys 
        675                 680                 685             


Ser Leu Tyr Glu Glu Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu 
    690                 695                 700                 


Ser Arg Asp Leu Glu Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu 
705                 710                 715                 720 


Lys Glu His Ile Thr Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu 
                725                 730                 735     


Glu Gln Asp Asn Leu Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys 
            740                 745                 750         


Leu Phe Val Lys Thr Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser 
        755                 760                 765             


Glu Val Ser Glu Asp Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln 
    770                 775                 780                 


Ala Val Gly Glu Ser Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu 
785                 790                 795                 800 


Ala Phe Gln Arg Asp Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys 
                805                 810                 815     


Cys Leu Gln Glu Glu Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu 
            820                 825                 830         


Leu Arg Asp Tyr Glu Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu 
        835                 840                 845             


Glu Ile Gln Ser Glu Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met 
    850                 855                 860                 


Lys Asn Ala Asn Glu Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile 
865                 870                 875                 880 


Gln Val Glu Glu Val Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn 
                885                 890                 895     


Glu Lys Glu Lys Cys Phe Ile Lys Glu His Glu Asn Leu Lys Pro Leu 
            900                 905                 910         


Leu Glu Gln Lys Glu Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu 
        915                 920                 925             


Lys Asp Ser Leu Ala Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser 
    930                 935                 940                 


Ser Val Lys Glu Leu Glu Glu Lys Ile Glu Asn Leu Glu Lys Glu Cys 
945                 950                 955                 960 


Lys Glu Lys Glu Glu Lys Ile Asn Lys Ile Lys Leu Val Ala Val Lys 
                965                 970                 975     


Ala Lys Lys Glu Leu Asp Ser Ser Arg Lys Glu Thr Gln Thr Val Lys 
            980                 985                 990         


Glu Glu Leu Glu Ser Leu Arg Ser  Glu Lys Asp Gln Leu  Ser Ala Ser 
        995                 1000                 1005             


Met Arg  Asp Leu Ile Gln Gly  Ala Glu Ser Tyr Lys  Asn Leu Leu 
    1010                 1015                 1020             


Leu Glu  Tyr Glu Lys Gln Ser  Glu Gln Leu Asp Val  Glu Lys Glu 
    1025                 1030                 1035             


Arg Ala  Asn Asn Phe Glu His  Arg Ile Glu Asp Leu  Thr Arg Gln 
    1040                 1045                 1050             


Leu Arg  Asn Ser Thr Leu Gln  Cys Glu Thr Ile Asn  Ser Asp Asn 
    1055                 1060                 1065             


Glu Asp  Leu Leu Ala Arg Ile  Glu Thr Leu Gln Ser  Asn Ala Lys 
    1070                 1075                 1080             


Leu Leu  Glu Val Gln Ile Leu  Glu Val Gln Arg Ala  Lys Ala Met 
    1085                 1090                 1095             


Val Asp  Lys Glu Leu Glu Ala  Glu Lys Leu Gln Lys  Glu Gln Lys 
    1100                 1105                 1110             


Ile Lys  Glu His Ala Thr Thr  Val Asn Glu Leu Glu  Glu Leu Gln 
    1115                 1120                 1125             


Val Gln  Leu Gln Lys Glu Lys  Lys Gln Leu Gln Lys  Thr Met Gln 
    1130                 1135                 1140             


Glu Leu  Glu Leu Val Lys Lys  Asp Ala Gln Gln Thr  Thr Leu Met 
    1145                 1150                 1155             


Asn Met  Glu Ile Ala Asp Tyr  Glu Arg Leu Met Lys  Glu Leu Asn 
    1160                 1165                 1170             


Gln Lys  Leu Thr Asn Lys Asn  Asn Lys Ile Glu Asp  Leu Glu Gln 
    1175                 1180                 1185             


Glu Ile  Lys Ile Gln Lys Gln  Lys Gln Glu Thr Leu  Gln Glu Glu 
    1190                 1195                 1200             


Ile Thr  Ser Leu Gln Ser Ser  Val Gln Gln Tyr Glu  Glu Lys Asn 
    1205                 1210                 1215             


Thr Lys  Ile Lys Gln Leu Leu  Val Lys Thr Lys Lys  Glu Leu Ala 
    1220                 1225                 1230             


Asp Ser  Lys Gln Ala Glu Thr  Asp His Leu Ile Leu  Gln Ala Ser 
    1235                 1240                 1245             


Leu Lys  Gly Glu Leu Glu Ala  Ser Gln Gln Gln Val  Glu Val Tyr 
    1250                 1255                 1260             


Lys Ile  Gln Leu Ala Glu Ile  Thr Ser Glu Lys His  Lys Ile His 
    1265                 1270                 1275             


Glu His  Leu Lys Thr Ser Ala  Glu Gln His Gln Arg  Thr Leu Ser 
    1280                 1285                 1290             


Ala Tyr  Gln Gln Arg Val Thr  Ala Leu Gln Glu Glu  Cys Arg Ala 
    1295                 1300                 1305             


Ala Lys  Ala Glu Gln Ala Thr  Val Thr Ser Glu Phe  Glu Ser Tyr 
    1310                 1315                 1320             


Lys Val  Arg Val His Asn Val  Leu Lys Gln Gln Lys  Asn Lys Ser 
    1325                 1330                 1335             


Met Ser  Gln Ala Glu Thr Glu  Gly Ala Lys Gln Glu  Arg Glu His 
    1340                 1345                 1350             


Leu Glu  Met Leu Ile Asp Gln  Leu Lys Ile Lys Leu  Gln Asp Ser 
    1355                 1360                 1365             


Gln Asn  Asn Leu Gln Ile Asn  Val Ser Glu Leu Gln  Thr Leu Gln 
    1370                 1375                 1380             


Ser Glu  His Asp Thr Leu Leu  Glu Arg His Asn Lys  Met Leu Gln 
    1385                 1390                 1395             


Glu Thr  Val Ser Lys Glu Ala  Glu Leu Arg Glu Lys  Leu Cys Ser 
    1400                 1405                 1410             


Ile Gln  Ser Glu Asn Met Met  Met Lys Ser Glu His  Thr Gln Thr 
    1415                 1420                 1425             


Val Ser  Gln Leu Thr Ser Gln  Asn Glu Val Leu Arg  Asn Ser Phe 
    1430                 1435                 1440             


Arg Asp  Gln Val Arg His Leu  Gln Glu Glu His Arg  Lys Thr Val 
    1445                 1450                 1455             


Glu Thr  Leu Gln Gln Gln Leu  Ser Lys Met Glu Ala  Gln Leu Phe 
    1460                 1465                 1470             


Gln Leu  Lys Asn Glu Pro Thr  Thr Arg Ser Pro Val  Ser Ser Gln 
    1475                 1480                 1485             


Gln Ser  Leu Lys Asn Leu Arg  Glu Arg Arg Asn Thr  Asp Leu Pro 
    1490                 1495                 1500             


Leu Leu  Asp Met His Thr Val  Thr Arg Glu Glu Gly  Glu Gly Met 
    1505                 1510                 1515             


Glu Thr  Thr Asp Thr Glu Ser  Val Ser Ser Ala Ser  Thr Tyr Thr 
    1520                 1525                 1530             


Gln Ser  Leu Glu Gln Leu Leu  Asn Ser Pro Glu Thr  Lys Leu Glu 
    1535                 1540                 1545             


Pro Pro  Leu Trp His Ala Glu  Phe Thr Lys Glu Glu  Leu Val Gln 
    1550                 1555                 1560             


Lys Leu  Ser Ser Thr Thr Lys  Ser Ala Asp His Leu  Asn Gly Leu 
    1565                 1570                 1575             


Leu Arg  Glu Thr Glu Ala Thr  Asn Ala Ile Leu Met  Glu Gln Ile 
    1580                 1585                 1590             


Lys Leu  Leu Lys Ser Glu Ile  Arg Arg Leu Glu Arg  Asn Gln Glu 
    1595                 1600                 1605             


Arg Glu  Lys Ser Ala Ala Asn  Leu Glu Tyr Leu Lys  Asn Val Leu 
    1610                 1615                 1620             


Leu Gln  Phe Ile Phe Leu Lys  Pro Gly Ser Glu Arg  Glu Arg Leu 
    1625                 1630                 1635             


Leu Pro  Val Ile Asn Thr Met  Leu Gln Leu Ser Pro  Glu Glu Lys 
    1640                 1645                 1650             


Gly Lys  Leu Ala Ala Val Ala  Gln Gly Glu Glu Glu  Asn Ala Ser 
    1655                 1660                 1665             


Arg Ser  Ser Gly Trp Ala Ser  Tyr Leu His Ser Trp  Ser Gly Leu 
    1670                 1675                 1680             


Arg 
    


<210>  593
<211>  534
<212>  DNA
<213>  Homosapiens

<400>  593
ctggcgcaaa cgcagcgggt ggctggggta ggggctcatt gggagcccac ggagcgcggc     60

ggcggctcgg gggccgagtt ccctacaaca aggatggcgg tgacgggcgc agggagcggg    120

gcccggctct ccttgcctcg aggctcctct gattccactc gcgtggctgc gcggccctgg    180

cagcggcctt cgtcccgggg gtgggagcta cacagggttc cgccccgtcc tggcgaggac    240

gcctgagggg gctctgtggt aaggctctgt cgggcaggcc gggcttccgg gaggacctgg    300

tctggatcgg tcaccgctgg gtgcctgagc tccgcatgga gcctgcagcc tttgtttaac    360

ttataaagaa atgggggctc cgagcagtca agaagaacat gccccaagtt attcgtcagt    420

gaggcggaaa ttgtggtgta cttgttccag accaactatg aagataggat gcccatccag    480

aagaacggga agcattttct tcctcacctt tggaaagtaa aacaaaaaaa aaaa          534


<210>  594
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  594

Met Ala Val Thr Gly Ala Gly Ser Gly Ala Arg Leu Ser Leu Pro Arg 
1               5                   10                  15      


Gly Ser Ser Asp Ser Thr Arg Val Ala Ala Arg Pro Trp Gln Arg Pro 
            20                  25                  30          


Ser Ser Arg Gly Trp Glu Leu His Arg Val Pro Pro Arg Pro Gly Glu 
        35                  40                  45              


Asp Ala 
    50  


<210>  595
<211>  1559
<212>  DNA
<213>  Homosapiens

<400>  595
tagttcaaga caacagagac aaagctaaga tgaggaagtt ctgtacagtt taggaaatag     60

aggctttcaa agataattcg cagtgatgtg aaactggcct cccaagccct gataacaaca    120

tggccaacgc cctggccagc gccacttgcg agcgctgcaa gggcggcttt gcgcccgctg    180

agaagatcgt gaacagtaat ggggagctgt accatgagca gtgtttcgtg tgcgctcagt    240

gcttccagca gttcccagaa ggactcttct atgagtttga aggaagaaag tactgtgaac    300

atgactttca gatgctcttt gccccttgct gtcatcagtg tggtgaattc atcattggcc    360

gagttatcaa agccatgaat aacagctggc atccggagtg cttccgctgt gacctctgcc    420

aggaagttct ggcagatatc gggtttgtca agaatgctgg gagacacctg tgtcgcccct    480

gtcataatcg tgagaaagcc agaggccttg ggaaatacat ctgccagaaa tgccatgcta    540

tcatcgatga gcagcctctg atattcaaga acgaccccta ccatccagac catttcaact    600

gcgccaactg cgggaaggag ctgactgccg atgcacggga gctgaaaggg gagctatact    660

gcctcccatg ccatgataaa atgggggtcc ccatctgtgg tgcttgccga cggcccatcg    720

aagggcgcgt ggtgaacgct atgggcaagc agtggcatgt ggagcatttt gtttgtgcca    780

agtgtgagaa accctttctt ggacatcgcc attatgagag gaaaggcctg gcatattgtg    840

aaactcacta taaccagcta tttggtgatg tttgcttcca ctgcaatcgt gttatagaag    900

gtgatgtggt ctctgctctt aataaggcct ggtgcgtgaa ctgctttgcc tgttctacct    960

gcaacactaa attaacactc aagaataagt ttgtggagtt tgacatgaag ccagtctgta   1020

agaagtgcta tgagaaattt ccattggagc tgaagaaaag acttaagaaa ctagctgaga   1080

ccttaggaag gaaataagtt cctttatttt ttcttttcta tgcaagataa gagattacca   1140

acattacttg tcttgatcta cccatattta aagctatatc tcaaagcagt tgagagaaga   1200

ggacctatat gaatggtttt atgtcatttt tttaattaaa aaagaaaaat tcatataatc   1260

gtgtttaaaa cacaaatgaa gtcagtattt gcctttgtta acccttatcc atttgttgac   1320

atgtagactg tttacaaaaa aaaaacacat ggttaaatgt taaattttaa ttaaggcccc   1380

caaaaattaa atataacttt ttaaaatgaa aggagtcacc ttttacatga ctcaggtgaa   1440

aaaacagtat aaacattaat ttactttgtg ttcaaaagaa aattccaact gctgttgggg   1500

aaggacacag aaaagaaaaa taaccaccca aaaaaaaaaa aaaaaaaaaa aaaaaaaaa    1559


<210>  596
<211>  325
<212>  PRT
<213>  Homosapiens

<400>  596

Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
1               5                   10                  15      


Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
    50                  55                  60                  


Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly 
65                  70                  75                  80  


Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg 
                85                  90                  95      


Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn 
            100                 105                 110         


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg 
        115                 120                 125             


Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu 
    130                 135                 140                 


Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn 
145                 150                 155                 160 


Cys Ala Asn Cys Gly Lys Glu Leu Thr Ala Asp Ala Arg Glu Leu Lys 
                165                 170                 175     


Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile 
            180                 185                 190         


Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Met 
        195                 200                 205             


Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys 
    210                 215                 220                 


Pro Phe Leu Gly His Arg His Tyr Glu Arg Lys Gly Leu Ala Tyr Cys 
225                 230                 235                 240 


Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Phe His Cys Asn 
                245                 250                 255     


Arg Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys 
            260                 265                 270         


Val Asn Cys Phe Ala Cys Ser Thr Cys Asn Thr Lys Leu Thr Leu Lys 
        275                 280                 285             


Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Lys Cys Tyr 
    290                 295                 300                 


Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ala Glu 
305                 310                 315                 320 


Thr Leu Gly Arg Lys 
                325 


<210>  597
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  597
cacagtggtc ctccgccggc tacggcgctg cgtcactggt ttgcaggcgc tttcctcttg     60

gaagtggcga ctgctgcggg cctgagcgct ggtctcacgc gcctcgggag ccaggttggc    120

ggcgcgatga ggcgcagcaa ggctgacgtg gagcggtaca tcgcctcggt gcagggctcc    180

accccgtcgc ctcgacagaa gtcaatgaaa ggattctatt ttgcaaagct gtattatgaa    240

gctaaagaat atgatcttgc taaaaaatac atatgtactt acattaatgt gcaagagagg    300

gatcccaaag ctcacagatt tctgggtctt ctttatgaat tggaagaaaa cacagacaaa    360

gccgttgaat gttacaggcg ttcagtggaa ttaaacccaa cacaaaaaga tcttgtgttg    420

aagattgcag aattgctttg taaaaatgat gttactgatg gaagagcaaa atactggctt    480

gaaagagcag ccaaactttt cccaggaagt cctgcaattt ataaactaaa ggaacagctt    540

ctagattgtg aaggtgaaga tggatggaat aaactttttg acttgattca gtcagaactt    600

tatgtaagac ctgatgacgt ccatgtgaac atccggctag tggaggtgta tcgctcaact    660

aaaagattga aggatgctgt ggcccactgc catgaggcag agaggaacat agctttgcgt    720

tcaagtttag aatggaattc gtgtgttgta cagaccctta aggaatatct ggagtcttta    780

cagtgtttgg agtctgataa aagtgactgg cgagcaacca atacagactt actgctggcc    840

tatgctaatc ttatgcttct tacgctttcc actagagatg tgcaggaaag tagagaatta    900

ctgcaaagtt ttgatagtgc tcttcagtct gtgaaatctt tgggtggaaa tgatgaactg    960

tcagctactt tcttagaaat gaaaggacat ttctacatgc atgctggttc tctgcttttg   1020

aagatgggtc agcatagtag taatgttcaa tggcgagctc tttctgagct ggctgcattg   1080

tgctatctca tagcatttca ggttccaaga ccaaagatta aattaataaa aggtgaagct   1140

ggacaaaatc tgctggaaat gatggcctgt gaccgactga gccaatcagg gcacatgttg   1200

ctaaacttaa gtcgtggcaa gcaagatttt ttaaaagaga ttgttgaaac ttttgccaac   1260

aaaagcgggc agtctgcatt atatgatgct ctgttttcta gtcagtcacc taaggataca   1320

tcttttcttg gtagcgatga tattggaaac attgatgtac gagaaccaga gcttgaagat   1380

ttgactagat acgatgttgg tgctattcga gcacataatg gtagtcttca gcaccttact   1440

tggcttggct tacagtggaa ttcattgcct gctttacctg gaatccgaaa atggctaaaa   1500

cagcttttcc atcatttgcc ccatgaaacc tcaaggcttg aaacaaatgc acctgaatca   1560

atatgtattt tagatcttga agtatttctc cttggagtag tatataccag ccacttacaa   1620

ttaaaggaga aatgtaattc tcaccacagc tcctatcagc cgttatgcct gccccttcct   1680

gtgtgtaaac agctttgtac agaaagacaa aaatcttggt gggatgcggt ttgtactctg   1740

attcacagaa aagcagtacc tggaaacgta gcaaaattga gacttctagt tcagcatgaa   1800

ataaacactc taagagccca ggaaaaacat ggccttcaac ctgctctgct tgtacattgg   1860

gcagaatgcc ttcagaaaac gggcagcggt cttaattctt tttatgatca acgagaatac   1920

atagggagaa gtgttcatta ttggaagaaa gttttgccat tgttgaagat aataaaaaag   1980

aagaacagta ttcctgaacc tattgatcct ctgtttaaac attttcatag tgtagacatt   2040

caggcatcag aaattgttga atatgaagaa gacgcacaca taacttttgc tatattggat   2100

gcagtaaatg gaaatataga agatgctgtg actgcttttg aatctataaa aagtgttgtt   2160

tcttattgga atcttgcact gatttttcac aggaaggcag aagacattga aaatgatgcc   2220

ctttctcctg aagaacaaga agaatgcaaa aattatctga gaaagaccag ggactaccta   2280

ataaagatta tagatgacag tgattcaaat ctttcagtgg tcaagaaatt gcctgtgccc   2340

ctggagtctg taaaagagat gcttaattca gtcatgcagg aactcgaaga ctatagtgaa   2400

ggaggtcctc tctataaaaa tggttctttg cgaaatgcag attcagaaat aaaacattct   2460

acaccgtctc ctaccaaata ttcactatca ccaagtaaaa gttacaagta ttctcccaaa   2520

acaccacctc gatgggcaga agatcagaat tctttactga aaatgatttg ccaacaagta   2580

gaggccatta agaaagaaat gcaggagttg aaactaaata gcagtaactc agcatcccct   2640

catcgttggc ccacagagaa ttatggacca gactcggtgc ctgatggata tcaggggtca   2700

cagacatttc atggggctcc actaacagtt gcaactactg gcccttcagt atattatagt   2760

cagtcaccag catataattc ccagtatctt ctcagaccag cagctaatgt tactcccaca   2820

aagggcccag tctatggcat gaataggctt ccaccccaac agcatattta tgcctatccg   2880

caacagatgc acacaccgcc agtgcaaagc tcatctgctt gtatgttctc tcaggagatg   2940

tatggtcctc ctgcattgcg ttttgagtct cctgcaacgg gaattctatc gcccaggggt   3000

gatgattact ttaattacaa tgttcaacag acaagcacaa atccaccttt gccagaacca   3060

ggatatttca caaaacctcc gattgcagct catgcttcaa gatctgcaga atctaagact   3120

atagaatttg ggaaaactaa ttttgttcag cccatgccgg gtgaaggatt aaggccatct   3180

ttgccaacac aagcacacac aacacagcca actcctttta aatttaactc aaatttcaaa   3240

tcaaatgatg gtgacttcac gttttcctca ccacaggttg tgacacagcc ccctcctgca   3300

gcttacagta acagtgaaag ccttttaggt ctcctgactt cagataaacc cttgcaagga   3360

gatggctata gtggagccaa accaattcct ggtggtcaaa ccattgggcc tcgaaataca   3420

ttcaattttg gaagcaaaaa tgtgtctgga atttcattta cagaaaacat ggggtcgagt   3480

cagcaaaaga attctggttt tcggcgaagt gatgatatgt ttactttcca tggtccaggg   3540

aaatcagtat ttggaacacc cactttagag acagcaaaca agaatcatga gacagatgga   3600

ggaagtgccc atggggatga tgatgatgac ggtcctcact ttgagcctgt agtacctctt   3660

cctgataaga ttgaagtaaa aactggtgag gaagatgaag aagaattctt ttgcaaccgc   3720

gcgaaattgt ttcgtttcga tgtagaatcc aaagaatgga aagaacgtgg gattggcaat   3780

gtaaaaatac tgaggcataa aacatctggt aaaattcgcc ttctaatgag acgagagcaa   3840

gtattgaaaa tctgtgcaaa tcattacatc agtccagata tgaaattgac accaaatgct   3900

ggatcagaca gatcttttgt atggcatgcc cttgattatg cagatgagtt gccaaaacca   3960

gaacaacttg ctattaggtt caaaactcct gaggaagcag cactttttaa atgcaagttt   4020

gaagaagccc agagcatttt aaaagcccca ggaacaaatg tagccatggc gtcaaatcag   4080

gctgtcagaa ttgtaaaaga acccacaagt catgataaca aggatatttg caaatctgat   4140

gctggaaacc tgaattttga atttcaggtt gcaaagaaag aagggtcttg gtggcattgt   4200

aacagctgct cattaaagaa tgcttcaact gctaagaaat gtgtatcatg ccaaaatcta   4260

aacccaagca ataaagagct cgttggccca ccattagctg aaactgtttt tactcctaaa   4320

accagcccag agaatgttca agatcgattt gcattggtga ctccaaagaa agaaggtcac   4380

tgggattgta gtatttgttt agtaagaaat gaacctactg tatctaggtg cattgcgtgt   4440

cagaatacaa aatctgctaa caaaagtgga tcttcatttg ttcatcaagc ttcatttaaa   4500

tttggccagg gagatcttcc taaacctatt aacagtgatt tcagatctgt tttttctaca   4560

aaggaaggac agtgggattg cagtgcatgt ttggtacaaa atgaggggag ctctacaaaa   4620

tgtgctgctt gtcagaatcc gagaaaacag agtctacctg ctacttctat tccaacacct   4680

gcctctttta agtttggtac ttcagagaca agtaaaactc taaaaagtgg atttgaagac   4740

atgtttgcta agaaggaagg acagtgggat tgcagttcat gcttagtgcg aaatgaagca   4800

aatgctacaa gatgtgttgc ttgtcagaat ccggataaac caagtccatc tacttctgtt   4860

ccagctcctg cctcttttaa gtttggtact tcagagacaa gcaaggctcc aaagagcgga   4920

tttgagggaa tgttcactaa gaaggaggga cagtgggatt gcagtgtgtg cttagtaaga   4980

aatgaagcca gtgctaccaa atgtattgct tgtcagaatc caggtaaaca aaatcaaact   5040

acttctgcag tttcaacacc tgcctcttca gagacaagca aggctccaaa gagcggattt   5100

gagggaatgt tcactaagaa ggagggacag tgggattgca gtgtgtgctt agtaagaaat   5160

gaagccagtg ctaccaaatg tattgcttgt cagaatccag gtaaacaaaa tcaaactact   5220

tctgcagttt caacacctgc ctcttcagag acaagcaagg ctccaaagag cggatttgag   5280

ggaatgttca ctaagaagga aggacagtgg gattgcagtg tgtgcttagt aagaaatgaa   5340

gccagtgcta ccaaatgtat tgcttgtcag tgtccaagta aacaaaatca aacaactgca   5400

atttcaacac ctgcctcttc ggagataagc aaggctccaa agagtggatt tgaaggaatg   5460

ttcatcagga aaggacagtg ggattgtagt gtttgctgtg tacaaaatga gagttcttcc   5520

ttaaaatgtg tggcttgtga tgcctctaaa ccaactcata aacctattgc agaagctcct   5580

tcagctttca cactgggctc agaaatgaag ttgcatgact cttctggaag tcaggtggga   5640

acaggattta aaagtaattt ctcagaaaaa gcttctaagt ttggcaatac agagcaagga   5700

ttcaaatttg ggcatgtgga tcaagaaaat tcaccttcat ttatgtttca gggttcttct   5760

aatacagaat ttaagtcaac caaagaagga ttttccatcc ctgtgtctgc tgatggattt   5820

aaatttggca tttcggaacc aggaaatcaa gaaaagaaaa gtgaaaagcc tcttgaaaat   5880

ggtactggct tccaggctca ggatattagt ggccagaaga atggccgtgg tgtgattttt   5940

ggccaaacaa gtagcacttt tacatttgca gatcttgcaa aatcaacttc aggagaagga   6000

tttcagtttg gcaaaaaaga ccccaatttc aagggatttt caggtgctgg agaaaaatta   6060

ttctcatcac aatacggtaa aatggccaat aaagcaaaca cttccggtga ctttgagaaa   6120

gatgatgatg cctataagac tgaggacagc gatgacatcc attttgaacc agtagttcaa   6180

atgcccgaaa aagtagaact tgtaacagga gaagaagatg aaaaagttct gtattcacag   6240

cgggtaaaac tatttagatt tgatgctgag gtaagtcagt ggaaagaaag gggcttgggg   6300

aacttaaaaa ttctcaaaaa cgaggtcaat ggcaaactaa gaatgctgat gcgaagagaa   6360

caagtactaa aagtgtgtgc taatcattgg ataacgacta cgatgaacct gaagcctctc   6420

tctggatcag atagagcatg gatgtggtta gccagtgatt tctctgatgg tgatgccaaa   6480

ctagagcagt tggcagcaaa atttaaaaca ccagagctgg ctgaagaatt caagcagaaa   6540

tttgaggaat gccagcggct tctgttagac ataccacttc aaactcccca taaacttgta   6600

gatactggca gagctgccaa gttaatacag agagctgaag aaatgaagag tggactgaaa   6660

gatttcaaaa catttttgac aaatgatcaa acaaaagtca ctgaggaaga aaataagggt   6720

tcaggtacag gtgcggccgg tgcctcagac acaacaataa aacccaatcc tgaaaacact   6780

gggcccacat tagaatggga taactatgat ttaagggaag atgctttgga tgatagtgtc   6840

agtagtagct cagtacatgc ttctccattg gcaagtagcc ctgtgagaaa aaatcttttc   6900

cgttttggtg agtcaacaac aggatttaac ttcagtttta aatctgcttt gagtccatct   6960

aagtctcctg ccaagttgaa tcagagtggg acttcagttg gcactgatga agaatctgat   7020

gttactcaag aagaagagag agatggacag tactttgaac ctgttgttcc tttacctgat   7080

ctagttgaag tatccagtgg tgaggaaaat gaacaagttg tttttagtca cagggcaaaa   7140

ctctacagat atgataaaga tgttggtcaa tggaaagaaa ggggcattgg tgatataaag   7200

attttacaga attatgataa taagcaagtt cgtatagtga tgagaaggga ccaagtatta   7260

aaactttgtg ccaatcacag aataactcca gacatgactt tgcaaaatat gaaagggaca   7320

gaaagagtat ggttgtggac tgcatgtgat tttgcagatg gagaaagaaa agtagagcat   7380

ttagctgttc gttttaaact acaggatgtt gcagactcgt ttaagaaaat ttttgatgaa   7440

gcaaaaacag cccaggaaaa agattctttg ataacacctc atgtttctcg gtcaagcact   7500

cccagagagt caccatgtgg caaaattgct gtagctgtat tagaagaaac cacaagagag   7560

aggacagatg ttattcaggg tgatgatgta gcagatgcaa cttcagaagt tgaagtgtct   7620

agcacatctg aaacaacacc aaaagcagtg gtttctcctc caaagtttgt atttggttca   7680

gagtctgtta aaagcatttt tagtagtgaa aaatcaaaac catttgcatt cggcaacagt   7740

tcagccactg ggtctttgtt tggatttagt tttaatgcac ctttgaaaag taacaatagt   7800

gaaactagtt cagtagccca gagtggatct gaaagcaaag tggaacctaa aaaatgtgaa   7860

ctgtcaaaga actctgatat cgaacagtct tcagatagca aagtcaaaaa tctctttgct   7920

tcctttccaa cggaagaatc ttcaatcaac tacacattta aaacaccaga aaaggcaaaa   7980

gagaagaaaa aacctgaaga ttctccctca gatgatgatg ttctcattgt atatgaacta   8040

actccaaccg ctgagcagaa agcccttgca accaaactta aacttcctcc aactttcttc   8100

tgctacaaga atagaccaga ttatgttagt gaagaagagg aggatgatga agatttcgaa   8160

acagctgtca agaaacttaa tggaaaacta ta                                 8192


<210>  598
<211>  3224
<212>  PRT
<213>  Homosapiens

<400>  598

Met Arg Arg Ser Lys Ala Asp Val Glu Arg Tyr Ile Ala Ser Val Gln 
1               5                   10                  15      


Gly Ser Thr Pro Ser Pro Arg Gln Lys Ser Met Lys Gly Phe Tyr Phe 
            20                  25                  30          


Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 
        35                  40                  45              


Ile Cys Thr Tyr Ile Asn Val Gln Glu Arg Asp Pro Lys Ala His Arg 
    50                  55                  60                  


Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Asp Lys Ala Val 
65                  70                  75                  80  


Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 
                85                  90                  95      


Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 
            100                 105                 110         


Arg Ala Lys Tyr Trp Leu Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 
        115                 120                 125             


Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 
    130                 135                 140                 


Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 
145                 150                 155                 160 


Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Val Tyr Arg 
                165                 170                 175     


Ser Thr Lys Arg Leu Lys Asp Ala Val Ala His Cys His Glu Ala Glu 
            180                 185                 190         


Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 
        195                 200                 205             


Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 
    210                 215                 220                 


Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 
225                 230                 235                 240 


Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg 
                245                 250                 255     


Glu Leu Leu Gln Ser Phe Asp Ser Ala Leu Gln Ser Val Lys Ser Leu 
            260                 265                 270         


Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly His 
        275                 280                 285             


Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His Ser 
    290                 295                 300                 


Ser Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys Tyr 
305                 310                 315                 320 


Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys Gly 
                325                 330                 335     


Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu Ser 
            340                 345                 350         


Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp Phe 
        355                 360                 365             


Leu Lys Glu Ile Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser Ala 
    370                 375                 380                 


Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser Phe 
385                 390                 395                 400 


Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Arg Glu Pro Glu Leu 
                405                 410                 415     


Glu Asp Leu Thr Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn Gly 
            420                 425                 430         


Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu Pro 
        435                 440                 445             


Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His Leu 
    450                 455                 460                 


Pro His Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile Cys 
465                 470                 475                 480 


Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser His 
                485                 490                 495     


Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln Pro 
            500                 505                 510         


Leu Cys Leu Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg Gln 
        515                 520                 525             


Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala Val 
    530                 535                 540                 


Pro Gly Asn Val Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile Asn 
545                 550                 555                 560 


Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu Val 
                565                 570                 575     


His Trp Ala Glu Cys Leu Gln Lys Thr Gly Ser Gly Leu Asn Ser Phe 
            580                 585                 590         


Tyr Asp Gln Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys Lys 
        595                 600                 605             


Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro Glu 
    610                 615                 620                 


Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln Ala 
625                 630                 635                 640 


Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Ile Thr Phe Ala Ile 
                645                 650                 655     


Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Val Thr Ala Phe Glu 
            660                 665                 670         


Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe His 
        675                 680                 685             


Arg Lys Ala Glu Asp Ile Glu Asn Asp Ala Leu Ser Pro Glu Glu Gln 
    690                 695                 700                 


Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr Arg Asp Tyr Leu Ile Lys 
705                 710                 715                 720 


Ile Ile Asp Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu Pro 
                725                 730                 735     


Val Pro Leu Glu Ser Val Lys Glu Met Leu Asn Ser Val Met Gln Glu 
            740                 745                 750         


Leu Glu Asp Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser Leu 
        755                 760                 765             


Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr Lys 
    770                 775                 780                 


Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Lys Thr Pro 
785                 790                 795                 800 


Pro Arg Trp Ala Glu Asp Gln Asn Ser Leu Leu Lys Met Ile Cys Gln 
                805                 810                 815     


Gln Val Glu Ala Ile Lys Lys Glu Met Gln Glu Leu Lys Leu Asn Ser 
            820                 825                 830         


Ser Asn Ser Ala Ser Pro His Arg Trp Pro Thr Glu Asn Tyr Gly Pro 
        835                 840                 845             


Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly Ala 
    850                 855                 860                 


Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln Ser 
865                 870                 875                 880 


Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val Thr 
                885                 890                 895     


Pro Thr Lys Gly Pro Val Tyr Gly Met Asn Arg Leu Pro Pro Gln Gln 
            900                 905                 910         


His Ile Tyr Ala Tyr Pro Gln Gln Met His Thr Pro Pro Val Gln Ser 
        915                 920                 925             


Ser Ser Ala Cys Met Phe Ser Gln Glu Met Tyr Gly Pro Pro Ala Leu 
    930                 935                 940                 


Arg Phe Glu Ser Pro Ala Thr Gly Ile Leu Ser Pro Arg Gly Asp Asp 
945                 950                 955                 960 


Tyr Phe Asn Tyr Asn Val Gln Gln Thr Ser Thr Asn Pro Pro Leu Pro 
                965                 970                 975     


Glu Pro Gly Tyr Phe Thr Lys Pro Pro Ile Ala Ala His Ala Ser Arg 
            980                 985                 990         


Ser Ala Glu Ser Lys Thr Ile Glu  Phe Gly Lys Thr Asn  Phe Val Gln 
        995                 1000                 1005             


Pro Met  Pro Gly Glu Gly Leu  Arg Pro Ser Leu Pro  Thr Gln Ala 
    1010                 1015                 1020             


His Thr  Thr Gln Pro Thr Pro  Phe Lys Phe Asn Ser  Asn Phe Lys 
    1025                 1030                 1035             


Ser Asn  Asp Gly Asp Phe Thr  Phe Ser Ser Pro Gln  Val Val Thr 
    1040                 1045                 1050             


Gln Pro  Pro Pro Ala Ala Tyr  Ser Asn Ser Glu Ser  Leu Leu Gly 
    1055                 1060                 1065             


Leu Leu  Thr Ser Asp Lys Pro  Leu Gln Gly Asp Gly  Tyr Ser Gly 
    1070                 1075                 1080             


Ala Lys  Pro Ile Pro Gly Gly  Gln Thr Ile Gly Pro  Arg Asn Thr 
    1085                 1090                 1095             


Phe Asn  Phe Gly Ser Lys Asn  Val Ser Gly Ile Ser  Phe Thr Glu 
    1100                 1105                 1110             


Asn Met  Gly Ser Ser Gln Gln  Lys Asn Ser Gly Phe  Arg Arg Ser 
    1115                 1120                 1125             


Asp Asp  Met Phe Thr Phe His  Gly Pro Gly Lys Ser  Val Phe Gly 
    1130                 1135                 1140             


Thr Pro  Thr Leu Glu Thr Ala  Asn Lys Asn His Glu  Thr Asp Gly 
    1145                 1150                 1155             


Gly Ser  Ala His Gly Asp Asp  Asp Asp Asp Gly Pro  His Phe Glu 
    1160                 1165                 1170             


Pro Val  Val Pro Leu Pro Asp  Lys Ile Glu Val Lys  Thr Gly Glu 
    1175                 1180                 1185             


Glu Asp  Glu Glu Glu Phe Phe  Cys Asn Arg Ala Lys  Leu Phe Arg 
    1190                 1195                 1200             


Phe Asp  Val Glu Ser Lys Glu  Trp Lys Glu Arg Gly  Ile Gly Asn 
    1205                 1210                 1215             


Val Lys  Ile Leu Arg His Lys  Thr Ser Gly Lys Ile  Arg Leu Leu 
    1220                 1225                 1230             


Met Arg  Arg Glu Gln Val Leu  Lys Ile Cys Ala Asn  His Tyr Ile 
    1235                 1240                 1245             


Ser Pro  Asp Met Lys Leu Thr  Pro Asn Ala Gly Ser  Asp Arg Ser 
    1250                 1255                 1260             


Phe Val  Trp His Ala Leu Asp  Tyr Ala Asp Glu Leu  Pro Lys Pro 
    1265                 1270                 1275             


Glu Gln  Leu Ala Ile Arg Phe  Lys Thr Pro Glu Glu  Ala Ala Leu 
    1280                 1285                 1290             


Phe Lys  Cys Lys Phe Glu Glu  Ala Gln Ser Ile Leu  Lys Ala Pro 
    1295                 1300                 1305             


Gly Thr  Asn Val Ala Met Ala  Ser Asn Gln Ala Val  Arg Ile Val 
    1310                 1315                 1320             


Lys Glu  Pro Thr Ser His Asp  Asn Lys Asp Ile Cys  Lys Ser Asp 
    1325                 1330                 1335             


Ala Gly  Asn Leu Asn Phe Glu  Phe Gln Val Ala Lys  Lys Glu Gly 
    1340                 1345                 1350             


Ser Trp  Trp His Cys Asn Ser  Cys Ser Leu Lys Asn  Ala Ser Thr 
    1355                 1360                 1365             


Ala Lys  Lys Cys Val Ser Cys  Gln Asn Leu Asn Pro  Ser Asn Lys 
    1370                 1375                 1380             


Glu Leu  Val Gly Pro Pro Leu  Ala Glu Thr Val Phe  Thr Pro Lys 
    1385                 1390                 1395             


Thr Ser  Pro Glu Asn Val Gln  Asp Arg Phe Ala Leu  Val Thr Pro 
    1400                 1405                 1410             


Lys Lys  Glu Gly His Trp Asp  Cys Ser Ile Cys Leu  Val Arg Asn 
    1415                 1420                 1425             


Glu Pro  Thr Val Ser Arg Cys  Ile Ala Cys Gln Asn  Thr Lys Ser 
    1430                 1435                 1440             


Ala Asn  Lys Ser Gly Ser Ser  Phe Val His Gln Ala  Ser Phe Lys 
    1445                 1450                 1455             


Phe Gly  Gln Gly Asp Leu Pro  Lys Pro Ile Asn Ser  Asp Phe Arg 
    1460                 1465                 1470             


Ser Val  Phe Ser Thr Lys Glu  Gly Gln Trp Asp Cys  Ser Ala Cys 
    1475                 1480                 1485             


Leu Val  Gln Asn Glu Gly Ser  Ser Thr Lys Cys Ala  Ala Cys Gln 
    1490                 1495                 1500             


Asn Pro  Arg Lys Gln Ser Leu  Pro Ala Thr Ser Ile  Pro Thr Pro 
    1505                 1510                 1515             


Ala Ser  Phe Lys Phe Gly Thr  Ser Glu Thr Ser Lys  Thr Leu Lys 
    1520                 1525                 1530             


Ser Gly  Phe Glu Asp Met Phe  Ala Lys Lys Glu Gly  Gln Trp Asp 
    1535                 1540                 1545             


Cys Ser  Ser Cys Leu Val Arg  Asn Glu Ala Asn Ala  Thr Arg Cys 
    1550                 1555                 1560             


Val Ala  Cys Gln Asn Pro Asp  Lys Pro Ser Pro Ser  Thr Ser Val 
    1565                 1570                 1575             


Pro Ala  Pro Ala Ser Phe Lys  Phe Gly Thr Ser Glu  Thr Ser Lys 
    1580                 1585                 1590             


Ala Pro  Lys Ser Gly Phe Glu  Gly Met Phe Thr Lys  Lys Glu Gly 
    1595                 1600                 1605             


Gln Trp  Asp Cys Ser Val Cys  Leu Val Arg Asn Glu  Ala Ser Ala 
    1610                 1615                 1620             


Thr Lys  Cys Ile Ala Cys Gln  Asn Pro Gly Lys Gln  Asn Gln Thr 
    1625                 1630                 1635             


Thr Ser  Ala Val Ser Thr Pro  Ala Ser Ser Glu Thr  Ser Lys Ala 
    1640                 1645                 1650             


Pro Lys  Ser Gly Phe Glu Gly  Met Phe Thr Lys Lys  Glu Gly Gln 
    1655                 1660                 1665             


Trp Asp  Cys Ser Val Cys Leu  Val Arg Asn Glu Ala  Ser Ala Thr 
    1670                 1675                 1680             


Lys Cys  Ile Ala Cys Gln Asn  Pro Gly Lys Gln Asn  Gln Thr Thr 
    1685                 1690                 1695             


Ser Ala  Val Ser Thr Pro Ala  Ser Ser Glu Thr Ser  Lys Ala Pro 
    1700                 1705                 1710             


Lys Ser  Gly Phe Glu Gly Met  Phe Thr Lys Lys Glu  Gly Gln Trp 
    1715                 1720                 1725             


Asp Cys  Ser Val Cys Leu Val  Arg Asn Glu Ala Ser  Ala Thr Lys 
    1730                 1735                 1740             


Cys Ile  Ala Cys Gln Cys Pro  Ser Lys Gln Asn Gln  Thr Thr Ala 
    1745                 1750                 1755             


Ile Ser  Thr Pro Ala Ser Ser  Glu Ile Ser Lys Ala  Pro Lys Ser 
    1760                 1765                 1770             


Gly Phe  Glu Gly Met Phe Ile  Arg Lys Gly Gln Trp  Asp Cys Ser 
    1775                 1780                 1785             


Val Cys  Cys Val Gln Asn Glu  Ser Ser Ser Leu Lys  Cys Val Ala 
    1790                 1795                 1800             


Cys Asp  Ala Ser Lys Pro Thr  His Lys Pro Ile Ala  Glu Ala Pro 
    1805                 1810                 1815             


Ser Ala  Phe Thr Leu Gly Ser  Glu Met Lys Leu His  Asp Ser Ser 
    1820                 1825                 1830             


Gly Ser  Gln Val Gly Thr Gly  Phe Lys Ser Asn Phe  Ser Glu Lys 
    1835                 1840                 1845             


Ala Ser  Lys Phe Gly Asn Thr  Glu Gln Gly Phe Lys  Phe Gly His 
    1850                 1855                 1860             


Val Asp  Gln Glu Asn Ser Pro  Ser Phe Met Phe Gln  Gly Ser Ser 
    1865                 1870                 1875             


Asn Thr  Glu Phe Lys Ser Thr  Lys Glu Gly Phe Ser  Ile Pro Val 
    1880                 1885                 1890             


Ser Ala  Asp Gly Phe Lys Phe  Gly Ile Ser Glu Pro  Gly Asn Gln 
    1895                 1900                 1905             


Glu Lys  Lys Ser Glu Lys Pro  Leu Glu Asn Gly Thr  Gly Phe Gln 
    1910                 1915                 1920             


Ala Gln  Asp Ile Ser Gly Gln  Lys Asn Gly Arg Gly  Val Ile Phe 
    1925                 1930                 1935             


Gly Gln  Thr Ser Ser Thr Phe  Thr Phe Ala Asp Leu  Ala Lys Ser 
    1940                 1945                 1950             


Thr Ser  Gly Glu Gly Phe Gln  Phe Gly Lys Lys Asp  Pro Asn Phe 
    1955                 1960                 1965             


Lys Gly  Phe Ser Gly Ala Gly  Glu Lys Leu Phe Ser  Ser Gln Tyr 
    1970                 1975                 1980             


Gly Lys  Met Ala Asn Lys Ala  Asn Thr Ser Gly Asp  Phe Glu Lys 
    1985                 1990                 1995             


Asp Asp  Asp Ala Tyr Lys Thr  Glu Asp Ser Asp Asp  Ile His Phe 
    2000                 2005                 2010             


Glu Pro  Val Val Gln Met Pro  Glu Lys Val Glu Leu  Val Thr Gly 
    2015                 2020                 2025             


Glu Glu  Asp Glu Lys Val Leu  Tyr Ser Gln Arg Val  Lys Leu Phe 
    2030                 2035                 2040             


Arg Phe  Asp Ala Glu Val Ser  Gln Trp Lys Glu Arg  Gly Leu Gly 
    2045                 2050                 2055             


Asn Leu  Lys Ile Leu Lys Asn  Glu Val Asn Gly Lys  Leu Arg Met 
    2060                 2065                 2070             


Leu Met  Arg Arg Glu Gln Val  Leu Lys Val Cys Ala  Asn His Trp 
    2075                 2080                 2085             


Ile Thr  Thr Thr Met Asn Leu  Lys Pro Leu Ser Gly  Ser Asp Arg 
    2090                 2095                 2100             


Ala Trp  Met Trp Leu Ala Ser  Asp Phe Ser Asp Gly  Asp Ala Lys 
    2105                 2110                 2115             


Leu Glu  Gln Leu Ala Ala Lys  Phe Lys Thr Pro Glu  Leu Ala Glu 
    2120                 2125                 2130             


Glu Phe  Lys Gln Lys Phe Glu  Glu Cys Gln Arg Leu  Leu Leu Asp 
    2135                 2140                 2145             


Ile Pro  Leu Gln Thr Pro His  Lys Leu Val Asp Thr  Gly Arg Ala 
    2150                 2155                 2160             


Ala Lys  Leu Ile Gln Arg Ala  Glu Glu Met Lys Ser  Gly Leu Lys 
    2165                 2170                 2175             


Asp Phe  Lys Thr Phe Leu Thr  Asn Asp Gln Thr Lys  Val Thr Glu 
    2180                 2185                 2190             


Glu Glu  Asn Lys Gly Ser Gly  Thr Gly Ala Ala Gly  Ala Ser Asp 
    2195                 2200                 2205             


Thr Thr  Ile Lys Pro Asn Pro  Glu Asn Thr Gly Pro  Thr Leu Glu 
    2210                 2215                 2220             


Trp Asp  Asn Tyr Asp Leu Arg  Glu Asp Ala Leu Asp  Asp Ser Val 
    2225                 2230                 2235             


Ser Ser  Ser Ser Val His Ala  Ser Pro Leu Ala Ser  Ser Pro Val 
    2240                 2245                 2250             


Arg Lys  Asn Leu Phe Arg Phe  Gly Glu Ser Thr Thr  Gly Phe Asn 
    2255                 2260                 2265             


Phe Ser  Phe Lys Ser Ala Leu  Ser Pro Ser Lys Ser  Pro Ala Lys 
    2270                 2275                 2280             


Leu Asn  Gln Ser Gly Thr Ser  Val Gly Thr Asp Glu  Glu Ser Asp 
    2285                 2290                 2295             


Val Thr  Gln Glu Glu Glu Arg  Asp Gly Gln Tyr Phe  Glu Pro Val 
    2300                 2305                 2310             


Val Pro  Leu Pro Asp Leu Val  Glu Val Ser Ser Gly  Glu Glu Asn 
    2315                 2320                 2325             


Glu Gln  Val Val Phe Ser His  Arg Ala Lys Leu Tyr  Arg Tyr Asp 
    2330                 2335                 2340             


Lys Asp  Val Gly Gln Trp Lys  Glu Arg Gly Ile Gly  Asp Ile Lys 
    2345                 2350                 2355             


Ile Leu  Gln Asn Tyr Asp Asn  Lys Gln Val Arg Ile  Val Met Arg 
    2360                 2365                 2370             


Arg Asp  Gln Val Leu Lys Leu  Cys Ala Asn His Arg  Ile Thr Pro 
    2375                 2380                 2385             


Asp Met  Thr Leu Gln Asn Met  Lys Gly Thr Glu Arg  Val Trp Leu 
    2390                 2395                 2400             


Trp Thr  Ala Cys Asp Phe Ala  Asp Gly Glu Arg Lys  Val Glu His 
    2405                 2410                 2415             


Leu Ala  Val Arg Phe Lys Leu  Gln Asp Val Ala Asp  Ser Phe Lys 
    2420                 2425                 2430             


Lys Ile  Phe Asp Glu Ala Lys  Thr Ala Gln Glu Lys  Asp Ser Leu 
    2435                 2440                 2445             


Ile Thr  Pro His Val Ser Arg  Ser Ser Thr Pro Arg  Glu Ser Pro 
    2450                 2455                 2460             


Cys Gly  Lys Ile Ala Val Ala  Val Leu Glu Glu Thr  Thr Arg Glu 
    2465                 2470                 2475             


Arg Thr  Asp Val Ile Gln Gly  Asp Asp Val Ala Asp  Ala Thr Ser 
    2480                 2485                 2490             


Glu Val  Glu Val Ser Ser Thr  Ser Glu Thr Thr Pro  Lys Ala Val 
    2495                 2500                 2505             


Val Ser  Pro Pro Lys Phe Val  Phe Gly Ser Glu Ser  Val Lys Ser 
    2510                 2515                 2520             


Ile Phe  Ser Ser Glu Lys Ser  Lys Pro Phe Ala Phe  Gly Asn Ser 
    2525                 2530                 2535             


Ser Ala  Thr Gly Ser Leu Phe  Gly Phe Ser Phe Asn  Ala Pro Leu 
    2540                 2545                 2550             


Lys Ser  Asn Asn Ser Glu Thr  Ser Ser Val Ala Gln  Ser Gly Ser 
    2555                 2560                 2565             


Glu Ser  Lys Val Glu Pro Lys  Lys Cys Glu Leu Ser  Lys Asn Ser 
    2570                 2575                 2580             


Asp Ile  Glu Gln Ser Ser Asp  Ser Lys Val Lys Asn  Leu Phe Ala 
    2585                 2590                 2595             


Ser Phe  Pro Thr Glu Glu Ser  Ser Ile Asn Tyr Thr  Phe Lys Thr 
    2600                 2605                 2610             


Pro Glu  Lys Ala Lys Glu Lys  Lys Lys Pro Glu Asp  Ser Pro Ser 
    2615                 2620                 2625             


Asp Asp  Asp Val Leu Ile Val  Tyr Glu Leu Thr Pro  Thr Ala Glu 
    2630                 2635                 2640             


Gln Lys  Ala Leu Ala Thr Lys  Leu Lys Leu Pro Pro  Thr Phe Phe 
    2645                 2650                 2655             


Cys Tyr  Lys Asn Arg Pro Asp  Tyr Val Ser Glu Glu  Glu Glu Asp 
    2660                 2665                 2670             


Asp Glu  Asp Phe Glu Thr Ala  Val Lys Lys Leu Asn  Gly Lys Leu 
    2675                 2680                 2685             


Tyr Leu  Asp Gly Ser Glu Lys  Cys Arg Pro Leu Glu  Glu Asn Thr 
    2690                 2695                 2700             


Ala Asp  Asn Glu Lys Glu Cys  Ile Ile Val Trp Glu  Lys Lys Pro 
    2705                 2710                 2715             


Thr Val  Glu Glu Lys Ala Lys  Ala Asp Thr Leu Lys  Leu Pro Pro 
    2720                 2725                 2730             


Thr Phe  Phe Cys Gly Val Cys  Ser Asp Thr Asp Glu  Asp Asn Gly 
    2735                 2740                 2745             


Asn Gly  Glu Asp Phe Gln Ser  Glu Leu Gln Lys Val  Gln Glu Ala 
    2750                 2755                 2760             


Gln Lys  Ser Gln Thr Glu Glu  Ile Thr Ser Thr Thr  Asp Ser Val 
    2765                 2770                 2775             


Tyr Thr  Gly Gly Thr Glu Val  Met Val Pro Ser Phe  Cys Lys Ser 
    2780                 2785                 2790             


Glu Glu  Pro Asp Ser Ile Thr  Lys Ser Ile Ser Ser  Pro Ser Val 
    2795                 2800                 2805             


Ser Ser  Glu Thr Met Asp Lys  Pro Val Asp Leu Ser  Thr Arg Lys 
    2810                 2815                 2820             


Glu Ile  Asp Thr Asp Ser Thr  Ser Gln Gly Glu Ser  Lys Ile Val 
    2825                 2830                 2835             


Ser Phe  Gly Phe Gly Ser Ser  Thr Gly Leu Ser Phe  Ala Asp Leu 
    2840                 2845                 2850             


Ala Ser  Ser Asn Ser Gly Asp  Phe Ala Phe Gly Ser  Lys Asp Lys 
    2855                 2860                 2865             


Asn Phe  Gln Trp Ala Asn Thr  Gly Ala Ala Val Phe  Gly Thr Gln 
    2870                 2875                 2880             


Ser Val  Gly Thr Gln Ser Ala  Gly Lys Val Gly Glu  Asp Glu Asp 
    2885                 2890                 2895             


Gly Ser  Asp Glu Glu Val Val  His Asn Glu Asp Ile  His Phe Glu 
    2900                 2905                 2910             


Pro Ile  Val Ser Leu Pro Glu  Val Glu Val Lys Ser  Gly Glu Glu 
    2915                 2920                 2925             


Asp Glu  Glu Ile Leu Phe Lys  Glu Arg Ala Lys Leu  Tyr Arg Trp 
    2930                 2935                 2940             


Asp Arg  Asp Val Ser Gln Trp  Lys Glu Arg Gly Val  Gly Asp Ile 
    2945                 2950                 2955             


Lys Ile  Leu Trp His Thr Met  Lys Asn Tyr Tyr Arg  Ile Leu Met 
    2960                 2965                 2970             


Arg Arg  Asp Gln Val Phe Lys  Val Cys Ala Asn His  Val Ile Thr 
    2975                 2980                 2985             


Lys Thr  Met Glu Leu Lys Pro  Leu Asn Val Ser Asn  Asn Ala Leu 
    2990                 2995                 3000             


Val Trp  Thr Ala Ser Asp Tyr  Ala Asp Gly Glu Ala  Lys Val Glu 
    3005                 3010                 3015             


Gln Leu  Ala Val Arg Phe Lys  Thr Lys Glu Val Ala  Asp Cys Phe 
    3020                 3025                 3030             


Lys Lys  Thr Phe Glu Glu Cys  Gln Gln Asn Leu Met  Lys Leu Gln 
    3035                 3040                 3045             


Lys Gly  His Val Ser Leu Ala  Ala Glu Leu Ser Lys  Glu Thr Asn 
    3050                 3055                 3060             


Pro Val  Val Phe Phe Asp Val  Cys Ala Asp Gly Glu  Pro Leu Gly 
    3065                 3070                 3075             


Arg Ile  Thr Met Glu Leu Phe  Ser Asn Ile Val Pro  Arg Thr Ala 
    3080                 3085                 3090             


Glu Asn  Phe Arg Ala Leu Cys  Thr Gly Glu Lys Gly  Phe Gly Phe 
    3095                 3100                 3105             


Lys Asn  Ser Ile Phe His Arg  Val Ile Pro Asp Phe  Val Cys Gln 
    3110                 3115                 3120             


Gly Gly  Asp Ile Thr Lys His  Asp Gly Thr Gly Gly  Gln Ser Ile 
    3125                 3130                 3135             


Tyr Gly  Asp Lys Phe Glu Asp  Glu Asn Phe Asp Val  Lys His Thr 
    3140                 3145                 3150             


Gly Pro  Gly Leu Leu Ser Met  Ala Asn Gln Gly Gln  Asn Thr Asn 
    3155                 3160                 3165             


Asn Ser  Gln Phe Val Ile Thr  Leu Lys Lys Ala Glu  His Leu Asp 
    3170                 3175                 3180             


Phe Lys  His Val Val Phe Gly  Phe Val Lys Asp Gly  Met Asp Thr 
    3185                 3190                 3195             


Val Lys  Lys Ile Glu Ser Phe  Gly Ser Pro Lys Gly  Ser Val Cys 
    3200                 3205                 3210             


Arg Arg  Ile Thr Ile Thr Glu  Cys Gly Gln Ile 
    3215                 3220                 


<210>  599
<211>  2196
<212>  DNA
<213>  Homosapiens

<400>  599
gtagcgccgc gggtttgatg aacgcggttc ccggggagac tggtacggtt gctgtgtgct     60

atggagccga gggtcgtcaa gccaccgggg caggatttag tagtggagag tctcaaaagc    120

cgctacggac tcgggggcag ctgccccgac gagtatgatt tttcaaattt ttatcagtct    180

aagtataaga gaagaactct aacctcccca ggtgatttgg atatctactc tggagataaa    240

gttggttcat cgttaaaata ttctgatgaa agcaagcatt gtagaacacc attgggcagc    300

ttattcaagc acgtaaatgt gaattgccta gatgatgaac tggattcttt ccatgatttg    360

aagaaacagg aaacagaaga agagttaatt gaaaatgatt atagagttag tacctcgaaa    420

ataaccaagc agtcttttaa agaaatagaa aaagttgcct tgccaactaa tacgacctca    480

tcgagacctc ggactgagtg ttgtagtgat gcaggtgact ctcctttgaa acctgtcagc    540

tgtccaaaat ctaaagcatc agacaagcgg agtttacttc cacatcagat cagtcagata    600

tatgacgaat tatttcagat acatctgaaa ttgcagtgtg aaactgcagc acaacagaaa    660

tttgctgaag aacttcaaaa gcgagaacgt tttttacttg aaagagaaca actgcttttc    720

agacatgaaa atgccttgag taaaattaaa ggtgttgaag aagaggttct tacaagattt    780

caaattataa aagagcagca tgatgcagaa gttgaacact taaccgaagt tcttaaggaa    840

aagaataaag aaaccaagag actgaggtcc tcttttgatg cattgaaaga attgaatgat    900

accttaaaaa aacagttaaa tgaagcaagt gaagaaaaca ggaagataga cattcaggct    960

aaaagagttc aagcacgttt agataattta cagaggaagt acgagtttat gacaatacag   1020

agattgaaag gaagttccca tgctgttcat gaaatgaaaa gtttaaaaca agaaaaagca   1080

ccagtttcaa aaacttacaa ggtaccactt aatgggcaag tttatgaact tttaactgtc   1140

ttcatggact ggatttcgga tcatcatctt agcaaagtga aacatgaaga atctggaatg   1200

gatggtaaaa aaccacaact caaatttgct tcccagagaa atgatattca ggagaagtgt   1260

gtaaagcttt tgcctctaat gacagagcag ctacagtgga tgccatttgt gaatatcaaa   1320

cttcacgagc cttttgtaaa atttatatat tggtccctaa ggcagctaga tgctggagca   1380

cagcactcga ctatgacatc aacattgagg agattgggtg aagacatttt taaaggagtg   1440

gtaactaaag gaattcagga taattctcca cagcattctg tggagaataa accaaagaca   1500

gctgctttct ttaagagctc caatttgcca ttgagatttt tatcaacctt aattgttctc   1560

aaaacagtca ctcaagctga ttacctggct caggcatttg attctctttg tttggacttg   1620

aagacagaag aaggaaaaac cttgtttttg gagtatcagg ctgttccagt aatattaagt   1680

catctaagaa tatccagtaa aggactcctg tctaatgtta ttgatagttt gctccagatg   1740

acggtggaat ctaaatcctt gcagcctttc ctggaagcct gtagcaactc tttatttttt   1800

cgtacttgct ctgtgctgct tcgagcccct aagcttgatc ttcaaatact agaaaaactc   1860

agtattattt tacagaaact ttccaaaatc aagagtaata agaagctctt tgaacttttt   1920

acgattcatc tgatgcttca agaaatacaa aggacaacaa acccagagca tgcatttctc   1980

tgtattaatc taaattcaac tctgttcaat ctgggtttaa caaaatgtaa ctccctggtc   2040

tccagtgcaa gcccttagac tggctaattt tttaatatag tatatgtggt gcttatttat   2100

aaacatgtag aaattaccaa agtaactaca attctaccaa gtaaagttat cagtagcatc   2160

atttatcatg aaaaataaat aatttttttg aactgt                             2196


<210>  600
<211>  665
<212>  PRT
<213>  Homosapiens

<400>  600

Met Glu Pro Arg Val Val Lys Pro Pro Gly Gln Asp Leu Val Val Glu 
1               5                   10                  15      


Ser Leu Lys Ser Arg Tyr Gly Leu Gly Gly Ser Cys Pro Asp Glu Tyr 
            20                  25                  30          


Asp Phe Ser Asn Phe Tyr Gln Ser Lys Tyr Lys Arg Arg Thr Leu Thr 
        35                  40                  45              


Ser Pro Gly Asp Leu Asp Ile Tyr Ser Gly Asp Lys Val Gly Ser Ser 
    50                  55                  60                  


Leu Lys Tyr Ser Asp Glu Ser Lys His Cys Arg Thr Pro Leu Gly Ser 
65                  70                  75                  80  


Leu Phe Lys His Val Asn Val Asn Cys Leu Asp Asp Glu Leu Asp Ser 
                85                  90                  95      


Phe His Asp Leu Lys Lys Gln Glu Thr Glu Glu Glu Leu Ile Glu Asn 
            100                 105                 110         


Asp Tyr Arg Val Ser Thr Ser Lys Ile Thr Lys Gln Ser Phe Lys Glu 
        115                 120                 125             


Ile Glu Lys Val Ala Leu Pro Thr Asn Thr Thr Ser Ser Arg Pro Arg 
    130                 135                 140                 


Thr Glu Cys Cys Ser Asp Ala Gly Asp Ser Pro Leu Lys Pro Val Ser 
145                 150                 155                 160 


Cys Pro Lys Ser Lys Ala Ser Asp Lys Arg Ser Leu Leu Pro His Gln 
                165                 170                 175     


Ile Ser Gln Ile Tyr Asp Glu Leu Phe Gln Ile His Leu Lys Leu Gln 
            180                 185                 190         


Cys Glu Thr Ala Ala Gln Gln Lys Phe Ala Glu Glu Leu Gln Lys Arg 
        195                 200                 205             


Glu Arg Phe Leu Leu Glu Arg Glu Gln Leu Leu Phe Arg His Glu Asn 
    210                 215                 220                 


Ala Leu Ser Lys Ile Lys Gly Val Glu Glu Glu Val Leu Thr Arg Phe 
225                 230                 235                 240 


Gln Ile Ile Lys Glu Gln His Asp Ala Glu Val Glu His Leu Thr Glu 
                245                 250                 255     


Val Leu Lys Glu Lys Asn Lys Glu Thr Lys Arg Leu Arg Ser Ser Phe 
            260                 265                 270         


Asp Ala Leu Lys Glu Leu Asn Asp Thr Leu Lys Lys Gln Leu Asn Glu 
        275                 280                 285             


Ala Ser Glu Glu Asn Arg Lys Ile Asp Ile Gln Ala Lys Arg Val Gln 
    290                 295                 300                 


Ala Arg Leu Asp Asn Leu Gln Arg Lys Tyr Glu Phe Met Thr Ile Gln 
305                 310                 315                 320 


Arg Leu Lys Gly Ser Ser His Ala Val His Glu Met Lys Ser Leu Lys 
                325                 330                 335     


Gln Glu Lys Ala Pro Val Ser Lys Thr Tyr Lys Val Pro Leu Asn Gly 
            340                 345                 350         


Gln Val Tyr Glu Leu Leu Thr Val Phe Met Asp Trp Ile Ser Asp His 
        355                 360                 365             


His Leu Ser Lys Val Lys His Glu Glu Ser Gly Met Asp Gly Lys Lys 
    370                 375                 380                 


Pro Gln Leu Lys Phe Ala Ser Gln Arg Asn Asp Ile Gln Glu Lys Cys 
385                 390                 395                 400 


Val Lys Leu Leu Pro Leu Met Thr Glu Gln Leu Gln Trp Met Pro Phe 
                405                 410                 415     


Val Asn Ile Lys Leu His Glu Pro Phe Val Lys Phe Ile Tyr Trp Ser 
            420                 425                 430         


Leu Arg Gln Leu Asp Ala Gly Ala Gln His Ser Thr Met Thr Ser Thr 
        435                 440                 445             


Leu Arg Arg Leu Gly Glu Asp Ile Phe Lys Gly Val Val Thr Lys Gly 
    450                 455                 460                 


Ile Gln Asp Asn Ser Pro Gln His Ser Val Glu Asn Lys Pro Lys Thr 
465                 470                 475                 480 


Ala Ala Phe Phe Lys Ser Ser Asn Leu Pro Leu Arg Phe Leu Ser Thr 
                485                 490                 495     


Leu Ile Val Leu Lys Thr Val Thr Gln Ala Asp Tyr Leu Ala Gln Ala 
            500                 505                 510         


Phe Asp Ser Leu Cys Leu Asp Leu Lys Thr Glu Glu Gly Lys Thr Leu 
        515                 520                 525             


Phe Leu Glu Tyr Gln Ala Val Pro Val Ile Leu Ser His Leu Arg Ile 
    530                 535                 540                 


Ser Ser Lys Gly Leu Leu Ser Asn Val Ile Asp Ser Leu Leu Gln Met 
545                 550                 555                 560 


Thr Val Glu Ser Lys Ser Leu Gln Pro Phe Leu Glu Ala Cys Ser Asn 
                565                 570                 575     


Ser Leu Phe Phe Arg Thr Cys Ser Val Leu Leu Arg Ala Pro Lys Leu 
            580                 585                 590         


Asp Leu Gln Ile Leu Glu Lys Leu Ser Ile Ile Leu Gln Lys Leu Ser 
        595                 600                 605             


Lys Ile Lys Ser Asn Lys Lys Leu Phe Glu Leu Phe Thr Ile His Leu 
    610                 615                 620                 


Met Leu Gln Glu Ile Gln Arg Thr Thr Asn Pro Glu His Ala Phe Leu 
625                 630                 635                 640 


Cys Ile Asn Leu Asn Ser Thr Leu Phe Asn Leu Gly Leu Thr Lys Cys 
                645                 650                 655     


Asn Ser Leu Val Ser Ser Ala Ser Pro 
            660                 665 


<210>  601
<211>  4235
<212>  DNA
<213>  Homosapiens

<400>  601
gggggcagac ggccgaagag ccaggtgtgc cagggaccta tggcagcagg gctgaacgtg     60

cccgctccag cctctccagt gctgggagag acctctagat ggtgcaggtg agtttgcaat    120

gagggaaagc ccctcggcaa ggactgagtt tccaaacttg cagacagggc agggagcggt    180

caaggaagag ttcccgggaa gccctttaaa cggaaaggaa gcggggctag tgtcagagag    240

gtgtgccagg tcccaggcag ccctgctgac ccctaaggac atagagtacc tgcttctgag    300

agggctgcca cggtggccac ctgtgaagcc tgtcacccag aactggatgg tacctgactt    360

tcttcataga cccatcttct gctgggactg aagctgacct ccaacagaag ccaggtgagc    420

ccttgggaga ggatggccca tgtgggggac tgcacgcaga cgccctggct ccccgtcctg    480

gtggtgtctc tgatgtgctc agcccgagcg gaatactcaa actgcggtga gaacgagtac    540

tacaaccaga ctacggggct gtgccaggag tgccccccgt gtgggccggg agaggagccc    600

tacctgtcct gtggctacgg caccaaagac gaggactacg gctgcgtccc ctgcccggcg    660

gagaagtttt ccaaaggagg ctaccagata tgcaggcgtc acaaagactg tgagggcttc    720

ttccgggcca ccgtgctgac accaggggac atggagaatg acgctgagtg tggcccttgc    780

ctccctggct actacatgct ggagaacaga ccgaggaaca tctatggcat ggtctgctac    840

tcctgcctcc tggcaccccc caacaccaag gaatgtgtgg gagccacttc aggagcttct    900

gccaacttcc ctggcacctc gggcagcagc accctgtctc ccttccagca cgcccacaaa    960

gaactctcag gccaaggaca cctggccact gccctgatca ttgcaatgtc caccatcttc   1020

atcatggcca tcgccatcgt cctcatcatc atgttctaca tcctgaagac aaagccctct   1080

gccccagcct gttgcaccag ccacccgggg aagagcgtgg aggcccaagt gagcaaggac   1140

gaggagaaga aagaggcccc agacaacgtg gtgatgttct ccgagaagga tgaatttgag   1200

aagctgacag caactccagc aaagcccacc aagagcgaga acgatgcctc atccgagaat   1260

gagcagctgc tgagccggag cgtcgacagt gatgaggagc ccgcccctga caagcagggc   1320

tccccggagc tgtgcctgct gtcgctggtt cacctggcca gggagaagtc tgccaccagc   1380

aacaagtcag ccgggattca aagccggagg aaaaagatcc tcgatgtgta tgccaacgtg   1440

tgtggagtcg tggaaggtct tagccccacg gagctgccat ttgattgcct cgagaagact   1500

agccgaatgc tcagctccac gtacaactct gagaaggctg ttgtgaaaac gtggcgccac   1560

ctcgccgaga gcttcggcct gaagagggat gagattgggg gcatgacaga cggcatgcaa   1620

ctctttgacc gcatcagcac ggcaggctac agcatccctg agctactcac aaaactggtg   1680

cagattgagc ggctggatgc tgtggagtcc ttgtgtgcag acatactgga gtgggcgggg   1740

gttgtgccac ctgcctccca gccacatgct gcatcctgaa aagcatgcct gtgggctgtc   1800

ctcccaggac aagccaagga tccaacgagg gctctggagc tgtgagtggt gccaaaagac   1860

tgccaagaat caaggctttt gtgatatgtc accgtatgcc ttaggatgtt caaggagcca   1920

gacgaaataa ggcctgtctt ccaatttaac caaagataaa ggactagagc cgggatactt   1980

tcagatgctc gcctgtacct caccaggcag agtaaatatc tactcactca tacagccagc   2040

ccaccagccc accattaact cactgaacaa tgagacaatg ttgaggactc aaatgaatca   2100

aaccccgtgg gaatgacaga agtgaagaat ctggtccctg tctttaagga gtttgcactc   2160

cagtagaaga cagaaggaac gtatgtttac aaaccacttc actggaagac gtcaaacaag   2220

ctgaatgaag gggcgcttag aaaacgttaa tagaagttct aagcgggaga tgactcccta   2280

ctgggatgat gaaggatggc atcctagtga agaagcagct caaacatttt gataaaatgg   2340

caacaaaatg cagacaccct gctccaggta ttatttcagg tttagtacaa gtctgttaat   2400

accctatgtg gtttcattag gataactttt tacctatcct tgaggtcatc catattctta   2460

caggccttcc agtcaataat ggaagagctc actctataca aaaccaatat gcaaggcatg   2520

tgtttgtcca agcaattgga tgtgtgcagt agccaatttc atttactgca ttactctttg   2580

gcctgggaac cctgtggtct gcactacatg tgaatggcct tccacttcag tcttaggcag   2640

atttgacctt ttaggggcag caatgctgaa ggacacagca atttaaatta taatgtgtca   2700

ggctgtgttt tcacttcaaa catgtatgag tagtcagctg taattagaga aatgatgact   2760

tcctaagagt tcagccacgc ataattctag atttcaagag catctaagac ttgtggatta   2820

gcctcatggc atgagagttt cagactcagc cttctgagcc agtcagggaa agtggagttc   2880

tgcagcgcaa atgagagcct gggcttggtg tcgagggagc tggcttctag ttgtgccacc   2940

ttgggccttg tcttttcctc tctctgcctc agtttctcgt ctgccaatga gatgttagtt   3000

agtgattcta taattggggc aggtagggtt caggtgagca aaaagaaagt ggagctatag   3060

gaaatgccag gcctttgagg tgctctatgg aagtcaacac agtgtggttt gtccatttaa   3120

atgggaataa aaacagaaaa actcagactt ggcattttca caataactgc aatggtttga   3180

cataacattt ataggcagaa agttaataaa ctggcattgt tcttggcata ttattgtact   3240

atccctgtaa ctgccaagag ctcaggagcc aggctagtga tcacaccagg ggttagagtt   3300

cactgctgaa ctccctgatg gcaggtctgt gtttattact acattaaaac aaagtctctg   3360

acttataaag cgaggtcgta aaaattacaa gttgcatgac tgaaaaaatg ctttaggggg   3420

aaaatcagtc atatctttaa caccaacaag caatttccca ccaacgaatg tagtacatac   3480

tgtgagagga tcataatgag gtcctgaata tttaatatca tcatttactg tgtctgtttg   3540

ctgctgtttt tcgaacctat ttggtttacc ctgcaagcta aatactccac ggcagagctt   3600

aattatcctt ttaattcctc tttgaaatcc tgtggtgccc ccttccccct gccttgtgat   3660

gatgatgagt gagtctcccc ttaattagac tgcaaatgtc acttgtgatg agtgtgccat   3720

tccaggataa cagcttgcac cctcctcaga atgttttcag cgaaagagtg gggtggctgt   3780

tctctgctcc tggtgctttg gcctcatttc acactattag aattctgggg ctgtaaggcc   3840

agccagtgtc agctcatgtt ccattggctc tccacctgcc atttttaggg agctattcct   3900

tatatagtta caaattccct tgtcatttac ttatttggaa acatgggatt tactctgaca   3960

agctttagcc tatgttatgg gattcagaac aatgagatca taataattct cactgaccaa   4020

agctgggact ccatcctgcc atttttgtgt ggagatattc ataattctgc aatactttaa   4080

aacatttaga aaacacccca gggtaggtct gtggccctta gacagtgaag tcttaattgt   4140

caatattatt tttgtctaat tctgtatata tataacttat tatattttat aatctcaata   4200

aacacattaa taaaaaaaaa aaaaaaaaaa aaaaa                              4235


<210>  602
<211>  448
<212>  PRT
<213>  Homosapiens

<400>  602

Met Ala His Val Gly Asp Cys Thr Gln Thr Pro Trp Leu Pro Val Leu 
1               5                   10                  15      


Val Val Ser Leu Met Cys Ser Ala Arg Ala Glu Tyr Ser Asn Cys Gly 
            20                  25                  30          


Glu Asn Glu Tyr Tyr Asn Gln Thr Thr Gly Leu Cys Gln Glu Cys Pro 
        35                  40                  45              


Pro Cys Gly Pro Gly Glu Glu Pro Tyr Leu Ser Cys Gly Tyr Gly Thr 
    50                  55                  60                  


Lys Asp Glu Asp Tyr Gly Cys Val Pro Cys Pro Ala Glu Lys Phe Ser 
65                  70                  75                  80  


Lys Gly Gly Tyr Gln Ile Cys Arg Arg His Lys Asp Cys Glu Gly Phe 
                85                  90                  95      


Phe Arg Ala Thr Val Leu Thr Pro Gly Asp Met Glu Asn Asp Ala Glu 
            100                 105                 110         


Cys Gly Pro Cys Leu Pro Gly Tyr Tyr Met Leu Glu Asn Arg Pro Arg 
        115                 120                 125             


Asn Ile Tyr Gly Met Val Cys Tyr Ser Cys Leu Leu Ala Pro Pro Asn 
    130                 135                 140                 


Thr Lys Glu Cys Val Gly Ala Thr Ser Gly Ala Ser Ala Asn Phe Pro 
145                 150                 155                 160 


Gly Thr Ser Gly Ser Ser Thr Leu Ser Pro Phe Gln His Ala His Lys 
                165                 170                 175     


Glu Leu Ser Gly Gln Gly His Leu Ala Thr Ala Leu Ile Ile Ala Met 
            180                 185                 190         


Ser Thr Ile Phe Ile Met Ala Ile Ala Ile Val Leu Ile Ile Met Phe 
        195                 200                 205             


Tyr Ile Leu Lys Thr Lys Pro Ser Ala Pro Ala Cys Cys Thr Ser His 
    210                 215                 220                 


Pro Gly Lys Ser Val Glu Ala Gln Val Ser Lys Asp Glu Glu Lys Lys 
225                 230                 235                 240 


Glu Ala Pro Asp Asn Val Val Met Phe Ser Glu Lys Asp Glu Phe Glu 
                245                 250                 255     


Lys Leu Thr Ala Thr Pro Ala Lys Pro Thr Lys Ser Glu Asn Asp Ala 
            260                 265                 270         


Ser Ser Glu Asn Glu Gln Leu Leu Ser Arg Ser Val Asp Ser Asp Glu 
        275                 280                 285             


Glu Pro Ala Pro Asp Lys Gln Gly Ser Pro Glu Leu Cys Leu Leu Ser 
    290                 295                 300                 


Leu Val His Leu Ala Arg Glu Lys Ser Ala Thr Ser Asn Lys Ser Ala 
305                 310                 315                 320 


Gly Ile Gln Ser Arg Arg Lys Lys Ile Leu Asp Val Tyr Ala Asn Val 
                325                 330                 335     


Cys Gly Val Val Glu Gly Leu Ser Pro Thr Glu Leu Pro Phe Asp Cys 
            340                 345                 350         


Leu Glu Lys Thr Ser Arg Met Leu Ser Ser Thr Tyr Asn Ser Glu Lys 
        355                 360                 365             


Ala Val Val Lys Thr Trp Arg His Leu Ala Glu Ser Phe Gly Leu Lys 
    370                 375                 380                 


Arg Asp Glu Ile Gly Gly Met Thr Asp Gly Met Gln Leu Phe Asp Arg 
385                 390                 395                 400 


Ile Ser Thr Ala Gly Tyr Ser Ile Pro Glu Leu Leu Thr Lys Leu Val 
                405                 410                 415     


Gln Ile Glu Arg Leu Asp Ala Val Glu Ser Leu Cys Ala Asp Ile Leu 
            420                 425                 430         


Glu Trp Ala Gly Val Val Pro Pro Ala Ser Gln Pro His Ala Ala Ser 
        435                 440                 445             


<210>  603
<211>  6656
<212>  DNA
<213>  Homosapiens

<400>  603
atgtcggggt tcaggctggg tgaccacgtg tggctggagc ctccctccac ccacaagacc     60

ggcgtggcca tcgggggcat catcaaagag gcaaagccag gcaaagtctt ggttgaagat    120

gacgagggca aggaacactg gatccgagca gaggactttg gtgtcctcag tcccatgcac    180

cccaactcag tccagggtgt ggacgacatg atccgcctgg gggacctgaa cgaggcaggc    240

atggtgcaca acctcctgat ccgctaccag cagcacaaga tctatacata cacaggctcc    300

atcctggtgg ccgtcaaccc gttccaggtg ctgccgctct acaccctgga gcaggtacag    360

ctctactaca gccgccatat gggcgagctg cccccgcatg tctttgccat cgccaacaac    420

tgctacttca gcatgaagag gaacaagagg gaccagtgct gcatcatcag cggcgagtct    480

ggggctggca agacggagac caccaagctc atcctgcagt tcctggccac catcagtggc    540

cagcattcgt ggattgagca gcaggtcctg gaagccaacc ccatcctgga ggcctttgga    600

aatgccaaga caatccgcaa cgacaactca agccgctttg ggaagtacat tgacatctac    660

tttaacccca gcggggtgat cgagggcgcg cgcatcgagc aatttctcct ggagaagtcc    720

cgggtctgcc ggcaggctcc cgaggagcgg aactaccata tcttctactg catgctcatg    780

ggggtgagtg ctgaggacaa gcagctgctg agcctgggca cgccctccga gtaccactac    840

ctgaccatgg ggaactgcac ttcctgtgag gggctcaacg acgccaagga ctacgcccac    900

atccgctcgg ccatgaagat cctccagttc tccgactccg agagctggga cgtcatcaag    960

ctgctggctg ccattctcca cctggggaat gtggggttca tggcttcggt cttcgagaac   1020

ctggacgcct cagacgtgat ggagacgccc gcctttccca ccgtgatgaa gttactggag   1080

gtgcagcacc aggagctccg ggactgtctg atcaagcaca ccatcctcat ccgaggggaa   1140

tttgtcacca ggtccctgaa cattgcccag gctgctgacc ggagggacgc ctttgtcaag   1200

ggcatctatg ggcacctctt cctgtggatt gtcaagaaga tcaatgccgc catcttcaca   1260

ccaccagccc aggaccccaa aaatgtgcgg agggccatcg gcctcctgga catatttggc   1320

tttgaaaatt tcgagaacaa tagcttcgag cagctctgca tcaacttcgc caacgagcac   1380

ctgcagcagt tctttgtgca gcacgtgttc accatggagc aagaggagta ccgctcggag   1440

aacatctcct gggactatat ccactacacc gacaatcggc ccaccctgga cctgctggcc   1500

ctcaagccca tgagcatcat ctccctcctg gacgaagaaa gccgcttccc gcaggggaca   1560

gatctcacca tgctgcaaaa gctgaacagc gtccatgcca acaacaaggc cttcctacag   1620

cccaagaaca tccacgatgc cagatttggc attgcccatt ttgccggcga ggtgtactac   1680

caagcagaag gcttcctgga gaagaaccga gacgtgctga gcacagatat cctcaccctg   1740

gtttactcct ccaaaaacaa gtttctgagg gagatattca acttggagtt agcagagacc   1800

aagctgggcc atgggaccat ccgccaggca aaggcaggaa accatctctt caagtctgca   1860

gactcaaata aacggccctc caccttagga agccagttca aacagtctct ggaccagctg   1920

atgaaaatcc tgaccaactg ccagccttac ttcatccgct gcatcaaacc taatgagtac   1980

aagaagccgc tgctgttcga ccgggagctg tgcctgcggc agctgcgata ctcgggcatg   2040

atggagaccg tgcacatccg caagtcgggc ttccccatcc gctacacgtt cgaggagttc   2100

tcgcagaggt tcggcgtgtt gctgcccaac gccatgcgga tgcagctgca aggcaagctc   2160

cgccagatga ccctgggcat cactgacgtg tggctgcgga cagacaaaga ctggaaagcg   2220

gggaagacaa aaattttcct gagggatcat caggacactc tgctggaggt acagagaagc   2280

caggtgctag acagagcggc gctcagcatc cagaaagtcc ttcggggcta cagatacagg   2340

aaggagttcc tgaggcagag gcgggcagct gtgaccctgc aggcctggtg gagaggctac   2400

tgcaacagga ggaatttcaa gctgatcctc gtgggctttg agcgcctgca ggctattgcc   2460

cggagccagc cgctggcgag gcagtaccag gccatgcggc agaggacagt ccagctgcag   2520

gccctgtgca ggggatacct ggtgcgccag caagtccagg ccaagaggag ggcagtggtg   2580

gtcattcagg cccatgccag gggcatggct gcccggcgca acttccagca aaggaaggcc   2640

aatgcgccgc tggtcatccc ggccgagggg cagaaaagcc aaggcgctct ccctgccaag   2700

aagcgcagat ccatctacga caccgtcact gacacggaga tggtggagaa ggtgttcggc   2760

ttcctccctg ccatgattgg gggccaggag ggccaggcct cgccgcactt tgaggatctg   2820

gaatcgaaga cccagaagct gcttgaggtt gacctggaca cagtccccat ggcggaggag   2880

cctgaggagg atgtggatgg cctggccgag tacaccttcc ccaagtttgc tgtgacttac   2940

ttccagaaat cagccagcca cacacacatc cggcggcccc tccgataccc gttgctttac   3000

cacgaagatg acactgactg cttggccgcc ctggtcatat ggaacgtcat cctgaggttc   3060

atgggtgatc tcccagagcc agtgctgtat gccaggagca gccagcaggg cagctcagtg   3120

atgcggcaga tccatgacac gctgggcagg gagcacggtg cccaggttcc acagcacagt   3180

agatctgcac aggtggccag ccagctgaac attggagagg aggcattgga gcctgatggc   3240

cttggtgcag accggcccat gtccaacctg gagaaggtgc acttcatcgt gggctacgcc   3300

atcctgcggc ccagcctcag ggatgagatt tactgccaga tctgcaagca gctctcggag   3360

aacttcaaaa caagcagcct ggcccggggc tggatcctgc tcagcctctg cctcggctgc   3420

ttcccaccct cagagaggtt catgaagtat ctactgaact tcatcggcca agggccggcg   3480

acctacggcc ccttctgtgc cgagcgcctg agacgcacct atgccaatgg ggtgcgtgcg   3540

gagcccccca cctggctgga gctgcaggct gtcaagtcca agaagcacat ccccatccaa   3600

gtcatcttgg ccactggaga gagcctaacc gtccccgtgg actcagcctc cacatctcgg   3660

gaaatgtgca tgcacatcgc tcacaagcag ggcctcagcg accacctggg cttctccctc   3720

caggtcgccg tgtacgacaa gttctggtcc ctgggcagcg ggcgcgacca catgatggat   3780

gccatcgccc ggtgtgagca gatggcccag gagaggggcg agagccagcg ccagtcaccc   3840

tggcgcatct acttccggaa ggaattcttc accccctggc acgactcccg ggaggaccct   3900

gtcagcaccg agcttattta ccgccaagtc ctccgaggag tctggtctgg cgagtacagc   3960

ttcgagaagg aggaagagct ggttgagctg ctggcccggc actgctacgt gcagctcggc   4020

gcctcagcag agagcaaggc tgtccaggag ctgctgccca gctgcatccc ccacaagctg   4080

tacaggacca agcccccaga caggtgggcg agcctcgtca ctgccgcctg cgccaaggcc   4140

ccatacactc agaagcaagt cacaccactg gccgtgcgag agcaggtggt ggacgccgcc   4200

cgcctgcagt ggccgctgct cttctcccgg ctcttcgaag tcatcacact ctcaggcccc   4260

cgcctgccca agacgcagct gatcttggct gttaactgga aggggctttg cttcctggac   4320

cagcaggaga agatgctgct ggaactctct ttcccagagg tcatgggtct ggccaccaac   4380

agggaggccc agggcgggca gaggctgctg ctctccacga tgcatgagga gtacgagttt   4440

gtgtcaccca gcagtgtggc catcgctgag ctggtggccc tgttcctgga gggcctgaag   4500

gagaggtcca ttttcgccat ggccctgcag gacaggaagg ccacagatga caccaccctc   4560

ctggccttca agaaggggga cctgttggtc ctcacaaaga agcaggggct gctggcctct   4620

gagaactgga ccctcggcca gaacgacagg acaggcaaga cggggctggt gcccatggcc   4680

tgcctctaca ccatccccac ggtcactaag ccctcggcac agctgctgag cttgcttgcc   4740

atgtcaccag agaagaggaa gctggcggct caggaggggc agttcacaga gccacgtcct   4800

gaggagccac ccaaggaaaa gctgcacacc ctggaggagt tctcctatga gttcttcagg   4860

gctccagaga aggacatggt gagcatggcc gtgctgcccc tggcccgtgc ccgtggccac   4920

ctgtgggcct attcctgcga gccgctgcga cagccgctgc tcaagcgagt ccacgccaac   4980

gtcgacctct gggacatcgc ctgccagatc tttgtcgcca tcctccggta catgggcgac   5040

tacccttctc ggcaggcctg gcccaccctg gagctcaccg accagatctt cacactggcc   5100

ctgcagcacc cggccctcca ggacgaggtc tactgccaga tcctgaagca gctgacgcac   5160

aactccaaca ggcacagcga agagcggggc tggcagctgc tgtggctgtg cacgggcctc   5220

ttcccgccca gcaaggggct gctgccccat gcccagaagt ttatagacac tcggaggggg   5280

aagctgctgg cccccgactg cagccgccga atccagaagg tcctgaggac ggggccccgg   5340

aagcagcccc cgcaccaggt ggaggtggag gccgcagagc agaacgtctc ccgcatctgc   5400

cacaagatct acttccccaa tgacaccagt gagatgctgg aggtggttgc caacacacgg   5460

gtgcgggatg tgtgtgacag cattgccacc aggctgcagc tggcctcctg ggagggctgc   5520

agcctcttca tcaagatttc agacaaggtc atcagccaga aggagggaga cttcttcttt   5580

gattccttga gggaggtgtc tgactgggtg aagaagaaca agccccagaa agaaggggcc   5640

cccgtgacgc tcccctacca ggtgtacttc atgcggaaat tgtggctcaa catatctcca   5700

gggaaggatg tgaatgcaga caccatactc cattaccacc aggagctgcc caagtacctg   5760

cgcggattcc acaagtgttc gcgggaggat gccatccacc tggcgggcct catctacaag   5820

gcccagttca acaacgaccg gtcccagctg gctagtgtcc ccaagatcct gagggaactg   5880

gtgcctgaga acctcacacg cctgatgtcc tcggaggagt ggaaaaagag catccttcta   5940

gcctatgaca agcataagga caagacagtg gaggaggcca aggtggcctt cctgaagtgg   6000

atctgccggt ggcccacctt cggatccgcc ttcttcgagg tgaagcaaac ctcggagcct   6060

tcctacccgg acgtcatcct catcgccatc aaccgacatg gggttctgct catccacccc   6120

aagaccaagg acctgctcac cacctatccc ttcaccaaga tctccagctg gagcagcggc   6180

agcacctact tccacatggc gctggggagc ctgggccgtg gcagccgcct gctgtgcgag   6240

acctccctgg gctataagat ggatgacctg ctgacctcat atgtgcagca gctcctgagt   6300

gccatgaaca agcagcgggg ctccaaggcc ccagccctgg ccagcaccta gcagcggatg   6360

ctggcgtgtc tgctcaggcg cccttcccga cctctagcct ggcggcacct tcccaggccc   6420

tctcaaccca gggcctgtcc ttggcgggca gccttccatg ctgcccccca tacaaagccc   6480

actcagcccc gcaggcggcc ccctctgtcc tgggcgctgc ccagggaggc caaaagacgg   6540

gcccagaatg gggtcgggag tctcggaccc ccaggctatt ggtggatgac tgactgacag   6600

gacacctccc aaccccaccc caccccacca gaatgttcaa taaaaactcc tggagc       6656


<210>  604
<211>  2116
<212>  PRT
<213>  Homosapiens

<400>  604

Met Ser Gly Phe Arg Leu Gly Asp His Val Trp Leu Glu Pro Pro Ser 
1               5                   10                  15      


Thr His Lys Thr Gly Val Ala Ile Gly Gly Ile Ile Lys Glu Ala Lys 
            20                  25                  30          


Pro Gly Lys Val Leu Val Glu Asp Asp Glu Gly Lys Glu His Trp Ile 
        35                  40                  45              


Arg Ala Glu Asp Phe Gly Val Leu Ser Pro Met His Pro Asn Ser Val 
    50                  55                  60                  


Gln Gly Val Asp Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Met Val His Asn Leu Leu Ile Arg Tyr Gln Gln His Lys Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Phe Gln Val Leu Pro 
            100                 105                 110         


Leu Tyr Thr Leu Glu Gln Val Gln Leu Tyr Tyr Ser Arg His Met Gly 
        115                 120                 125             


Glu Leu Pro Pro His Val Phe Ala Ile Ala Asn Asn Cys Tyr Phe Ser 
    130                 135                 140                 


Met Lys Arg Asn Lys Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Thr Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Thr Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Asn Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile Tyr Phe Asn Pro Ser 
    210                 215                 220                 


Gly Val Ile Glu Gly Ala Arg Ile Glu Gln Phe Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Pro Glu Glu Arg Asn Tyr His Ile Phe Tyr 
                245                 250                 255     


Cys Met Leu Met Gly Val Ser Ala Glu Asp Lys Gln Leu Leu Ser Leu 
            260                 265                 270         


Gly Thr Pro Ser Glu Tyr His Tyr Leu Thr Met Gly Asn Cys Thr Ser 
        275                 280                 285             


Cys Glu Gly Leu Asn Asp Ala Lys Asp Tyr Ala His Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Ile Leu Gln Phe Ser Asp Ser Glu Ser Trp Asp Val Ile Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Val Gly Phe Met Ala Ser 
                325                 330                 335     


Val Phe Glu Asn Leu Asp Ala Ser Asp Val Met Glu Thr Pro Ala Phe 
            340                 345                 350         


Pro Thr Val Met Lys Leu Leu Glu Val Gln His Gln Glu Leu Arg Asp 
        355                 360                 365             


Cys Leu Ile Lys His Thr Ile Leu Ile Arg Gly Glu Phe Val Thr Arg 
    370                 375                 380                 


Ser Leu Asn Ile Ala Gln Ala Ala Asp Arg Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly His Leu Phe Leu Trp Ile Val Lys Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Phe Thr Pro Pro Ala Gln Asp Pro Lys Asn Val Arg Arg Ala 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Glu Asn Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Gln His Val Phe Thr Met Glu Gln Glu Glu Tyr Arg Ser Glu 
465                 470                 475                 480 


Asn Ile Ser Trp Asp Tyr Ile His Tyr Thr Asp Asn Arg Pro Thr Leu 
                485                 490                 495     


Asp Leu Leu Ala Leu Lys Pro Met Ser Ile Ile Ser Leu Leu Asp Glu 
            500                 505                 510         


Glu Ser Arg Phe Pro Gln Gly Thr Asp Leu Thr Met Leu Gln Lys Leu 
        515                 520                 525             


Asn Ser Val His Ala Asn Asn Lys Ala Phe Leu Gln Pro Lys Asn Ile 
    530                 535                 540                 


His Asp Ala Arg Phe Gly Ile Ala His Phe Ala Gly Glu Val Tyr Tyr 
545                 550                 555                 560 


Gln Ala Glu Gly Phe Leu Glu Lys Asn Arg Asp Val Leu Ser Thr Asp 
                565                 570                 575     


Ile Leu Thr Leu Val Tyr Ser Ser Lys Asn Lys Phe Leu Arg Glu Ile 
            580                 585                 590         


Phe Asn Leu Glu Leu Ala Glu Thr Lys Leu Gly His Gly Thr Ile Arg 
        595                 600                 605             


Gln Ala Lys Ala Gly Asn His Leu Phe Lys Ser Ala Asp Ser Asn Lys 
    610                 615                 620                 


Arg Pro Ser Thr Leu Gly Ser Gln Phe Lys Gln Ser Leu Asp Gln Leu 
625                 630                 635                 640 


Met Lys Ile Leu Thr Asn Cys Gln Pro Tyr Phe Ile Arg Cys Ile Lys 
                645                 650                 655     


Pro Asn Glu Tyr Lys Lys Pro Leu Leu Phe Asp Arg Glu Leu Cys Leu 
            660                 665                 670         


Arg Gln Leu Arg Tyr Ser Gly Met Met Glu Thr Val His Ile Arg Lys 
        675                 680                 685             


Ser Gly Phe Pro Ile Arg Tyr Thr Phe Glu Glu Phe Ser Gln Arg Phe 
    690                 695                 700                 


Gly Val Leu Leu Pro Asn Ala Met Arg Met Gln Leu Gln Gly Lys Leu 
705                 710                 715                 720 


Arg Gln Met Thr Leu Gly Ile Thr Asp Val Trp Leu Arg Thr Asp Lys 
                725                 730                 735     


Asp Trp Lys Ala Gly Lys Thr Lys Ile Phe Leu Arg Asp His Gln Asp 
            740                 745                 750         


Thr Leu Leu Glu Val Gln Arg Ser Gln Val Leu Asp Arg Ala Ala Leu 
        755                 760                 765             


Ser Ile Gln Lys Val Leu Arg Gly Tyr Arg Tyr Arg Lys Glu Phe Leu 
    770                 775                 780                 


Arg Gln Arg Arg Ala Ala Val Thr Leu Gln Ala Trp Trp Arg Gly Tyr 
785                 790                 795                 800 


Cys Asn Arg Arg Asn Phe Lys Leu Ile Leu Val Gly Phe Glu Arg Leu 
                805                 810                 815     


Gln Ala Ile Ala Arg Ser Gln Pro Leu Ala Arg Gln Tyr Gln Ala Met 
            820                 825                 830         


Arg Gln Arg Thr Val Gln Leu Gln Ala Leu Cys Arg Gly Tyr Leu Val 
        835                 840                 845             


Arg Gln Gln Val Gln Ala Lys Arg Arg Ala Val Val Val Ile Gln Ala 
    850                 855                 860                 


His Ala Arg Gly Met Ala Ala Arg Arg Asn Phe Gln Gln Arg Lys Ala 
865                 870                 875                 880 


Asn Ala Pro Leu Val Ile Pro Ala Glu Gly Gln Lys Ser Gln Gly Ala 
                885                 890                 895     


Leu Pro Ala Lys Lys Arg Arg Ser Ile Tyr Asp Thr Val Thr Asp Thr 
            900                 905                 910         


Glu Met Val Glu Lys Val Phe Gly Phe Leu Pro Ala Met Ile Gly Gly 
        915                 920                 925             


Gln Glu Gly Gln Ala Ser Pro His Phe Glu Asp Leu Glu Ser Lys Thr 
    930                 935                 940                 


Gln Lys Leu Leu Glu Val Asp Leu Asp Thr Val Pro Met Ala Glu Glu 
945                 950                 955                 960 


Pro Glu Glu Asp Val Asp Gly Leu Ala Glu Tyr Thr Phe Pro Lys Phe 
                965                 970                 975     


Ala Val Thr Tyr Phe Gln Lys Ser Ala Ser His Thr His Ile Arg Arg 
            980                 985                 990         


Pro Leu Arg Tyr Pro Leu Leu Tyr  His Glu Asp Asp Thr  Asp Cys Leu 
        995                 1000                 1005             


Ala Ala  Leu Val Ile Trp Asn  Val Ile Leu Arg Phe  Met Gly Asp 
    1010                 1015                 1020             


Leu Pro  Glu Pro Val Leu Tyr  Ala Arg Ser Ser Gln  Gln Gly Ser 
    1025                 1030                 1035             


Ser Val  Met Arg Gln Ile His  Asp Thr Leu Gly Arg  Glu His Gly 
    1040                 1045                 1050             


Ala Gln  Val Pro Gln His Ser  Arg Ser Ala Gln Val  Ala Ser Gln 
    1055                 1060                 1065             


Leu Asn  Ile Gly Glu Glu Ala  Leu Glu Pro Asp Gly  Leu Gly Ala 
    1070                 1075                 1080             


Asp Arg  Pro Met Ser Asn Leu  Glu Lys Val His Phe  Ile Val Gly 
    1085                 1090                 1095             


Tyr Ala  Ile Leu Arg Pro Ser  Leu Arg Asp Glu Ile  Tyr Cys Gln 
    1100                 1105                 1110             


Ile Cys  Lys Gln Leu Ser Glu  Asn Phe Lys Thr Ser  Ser Leu Ala 
    1115                 1120                 1125             


Arg Gly  Trp Ile Leu Leu Ser  Leu Cys Leu Gly Cys  Phe Pro Pro 
    1130                 1135                 1140             


Ser Glu  Arg Phe Met Lys Tyr  Leu Leu Asn Phe Ile  Gly Gln Gly 
    1145                 1150                 1155             


Pro Ala  Thr Tyr Gly Pro Phe  Cys Ala Glu Arg Leu  Arg Arg Thr 
    1160                 1165                 1170             


Tyr Ala  Asn Gly Val Arg Ala  Glu Pro Pro Thr Trp  Leu Glu Leu 
    1175                 1180                 1185             


Gln Ala  Val Lys Ser Lys Lys  His Ile Pro Ile Gln  Val Ile Leu 
    1190                 1195                 1200             


Ala Thr  Gly Glu Ser Leu Thr  Val Pro Val Asp Ser  Ala Ser Thr 
    1205                 1210                 1215             


Ser Arg  Glu Met Cys Met His  Ile Ala His Lys Gln  Gly Leu Ser 
    1220                 1225                 1230             


Asp His  Leu Gly Phe Ser Leu  Gln Val Ala Val Tyr  Asp Lys Phe 
    1235                 1240                 1245             


Trp Ser  Leu Gly Ser Gly Arg  Asp His Met Met Asp  Ala Ile Ala 
    1250                 1255                 1260             


Arg Cys  Glu Gln Met Ala Gln  Glu Arg Gly Glu Ser  Gln Arg Gln 
    1265                 1270                 1275             


Ser Pro  Trp Arg Ile Tyr Phe  Arg Lys Glu Phe Phe  Thr Pro Trp 
    1280                 1285                 1290             


His Asp  Ser Arg Glu Asp Pro  Val Ser Thr Glu Leu  Ile Tyr Arg 
    1295                 1300                 1305             


Gln Val  Leu Arg Gly Val Trp  Ser Gly Glu Tyr Ser  Phe Glu Lys 
    1310                 1315                 1320             


Glu Glu  Glu Leu Val Glu Leu  Leu Ala Arg His Cys  Tyr Val Gln 
    1325                 1330                 1335             


Leu Gly  Ala Ser Ala Glu Ser  Lys Ala Val Gln Glu  Leu Leu Pro 
    1340                 1345                 1350             


Ser Cys  Ile Pro His Lys Leu  Tyr Arg Thr Lys Pro  Pro Asp Arg 
    1355                 1360                 1365             


Trp Ala  Ser Leu Val Thr Ala  Ala Cys Ala Lys Ala  Pro Tyr Thr 
    1370                 1375                 1380             


Gln Lys  Gln Val Thr Pro Leu  Ala Val Arg Glu Gln  Val Val Asp 
    1385                 1390                 1395             


Ala Ala  Arg Leu Gln Trp Pro  Leu Leu Phe Ser Arg  Leu Phe Glu 
    1400                 1405                 1410             


Val Ile  Thr Leu Ser Gly Pro  Arg Leu Pro Lys Thr  Gln Leu Ile 
    1415                 1420                 1425             


Leu Ala  Val Asn Trp Lys Gly  Leu Cys Phe Leu Asp  Gln Gln Glu 
    1430                 1435                 1440             


Lys Met  Leu Leu Glu Leu Ser  Phe Pro Glu Val Met  Gly Leu Ala 
    1445                 1450                 1455             


Thr Asn  Arg Glu Ala Gln Gly  Gly Gln Arg Leu Leu  Leu Ser Thr 
    1460                 1465                 1470             


Met His  Glu Glu Tyr Glu Phe  Val Ser Pro Ser Ser  Val Ala Ile 
    1475                 1480                 1485             


Ala Glu  Leu Val Ala Leu Phe  Leu Glu Gly Leu Lys  Glu Arg Ser 
    1490                 1495                 1500             


Ile Phe  Ala Met Ala Leu Gln  Asp Arg Lys Ala Thr  Asp Asp Thr 
    1505                 1510                 1515             


Thr Leu  Leu Ala Phe Lys Lys  Gly Asp Leu Leu Val  Leu Thr Lys 
    1520                 1525                 1530             


Lys Gln  Gly Leu Leu Ala Ser  Glu Asn Trp Thr Leu  Gly Gln Asn 
    1535                 1540                 1545             


Asp Arg  Thr Gly Lys Thr Gly  Leu Val Pro Met Ala  Cys Leu Tyr 
    1550                 1555                 1560             


Thr Ile  Pro Thr Val Thr Lys  Pro Ser Ala Gln Leu  Leu Ser Leu 
    1565                 1570                 1575             


Leu Ala  Met Ser Pro Glu Lys  Arg Lys Leu Ala Ala  Gln Glu Gly 
    1580                 1585                 1590             


Gln Phe  Thr Glu Pro Arg Pro  Glu Glu Pro Pro Lys  Glu Lys Leu 
    1595                 1600                 1605             


His Thr  Leu Glu Glu Phe Ser  Tyr Glu Phe Phe Arg  Ala Pro Glu 
    1610                 1615                 1620             


Lys Asp  Met Val Ser Met Ala  Val Leu Pro Leu Ala  Arg Ala Arg 
    1625                 1630                 1635             


Gly His  Leu Trp Ala Tyr Ser  Cys Glu Pro Leu Arg  Gln Pro Leu 
    1640                 1645                 1650             


Leu Lys  Arg Val His Ala Asn  Val Asp Leu Trp Asp  Ile Ala Cys 
    1655                 1660                 1665             


Gln Ile  Phe Val Ala Ile Leu  Arg Tyr Met Gly Asp  Tyr Pro Ser 
    1670                 1675                 1680             


Arg Gln  Ala Trp Pro Thr Leu  Glu Leu Thr Asp Gln  Ile Phe Thr 
    1685                 1690                 1695             


Leu Ala  Leu Gln His Pro Ala  Leu Gln Asp Glu Val  Tyr Cys Gln 
    1700                 1705                 1710             


Ile Leu  Lys Gln Leu Thr His  Asn Ser Asn Arg His  Ser Glu Glu 
    1715                 1720                 1725             


Arg Gly  Trp Gln Leu Leu Trp  Leu Cys Thr Gly Leu  Phe Pro Pro 
    1730                 1735                 1740             


Ser Lys  Gly Leu Leu Pro His  Ala Gln Lys Phe Ile  Asp Thr Arg 
    1745                 1750                 1755             


Arg Gly  Lys Leu Leu Ala Pro  Asp Cys Ser Arg Arg  Ile Gln Lys 
    1760                 1765                 1770             


Val Leu  Arg Thr Gly Pro Arg  Lys Gln Pro Pro His  Gln Val Glu 
    1775                 1780                 1785             


Val Glu  Ala Ala Glu Gln Asn  Val Ser Arg Ile Cys  His Lys Ile 
    1790                 1795                 1800             


Tyr Phe  Pro Asn Asp Thr Ser  Glu Met Leu Glu Val  Val Ala Asn 
    1805                 1810                 1815             


Thr Arg  Val Arg Asp Val Cys  Asp Ser Ile Ala Thr  Arg Leu Gln 
    1820                 1825                 1830             


Leu Ala  Ser Trp Glu Gly Cys  Ser Leu Phe Ile Lys  Ile Ser Asp 
    1835                 1840                 1845             


Lys Val  Ile Ser Gln Lys Glu  Gly Asp Phe Phe Phe  Asp Ser Leu 
    1850                 1855                 1860             


Arg Glu  Val Ser Asp Trp Val  Lys Lys Asn Lys Pro  Gln Lys Glu 
    1865                 1870                 1875             


Gly Ala  Pro Val Thr Leu Pro  Tyr Gln Val Tyr Phe  Met Arg Lys 
    1880                 1885                 1890             


Leu Trp  Leu Asn Ile Ser Pro  Gly Lys Asp Val Asn  Ala Asp Thr 
    1895                 1900                 1905             


Ile Leu  His Tyr His Gln Glu  Leu Pro Lys Tyr Leu  Arg Gly Phe 
    1910                 1915                 1920             


His Lys  Cys Ser Arg Glu Asp  Ala Ile His Leu Ala  Gly Leu Ile 
    1925                 1930                 1935             


Tyr Lys  Ala Gln Phe Asn Asn  Asp Arg Ser Gln Leu  Ala Ser Val 
    1940                 1945                 1950             


Pro Lys  Ile Leu Arg Glu Leu  Val Pro Glu Asn Leu  Thr Arg Leu 
    1955                 1960                 1965             


Met Ser  Ser Glu Glu Trp Lys  Lys Ser Ile Leu Leu  Ala Tyr Asp 
    1970                 1975                 1980             


Lys His  Lys Asp Lys Thr Val  Glu Glu Ala Lys Val  Ala Phe Leu 
    1985                 1990                 1995             


Lys Trp  Ile Cys Arg Trp Pro  Thr Phe Gly Ser Ala  Phe Phe Glu 
    2000                 2005                 2010             


Val Lys  Gln Thr Ser Glu Pro  Ser Tyr Pro Asp Val  Ile Leu Ile 
    2015                 2020                 2025             


Ala Ile  Asn Arg His Gly Val  Leu Leu Ile His Pro  Lys Thr Lys 
    2030                 2035                 2040             


Asp Leu  Leu Thr Thr Tyr Pro  Phe Thr Lys Ile Ser  Ser Trp Ser 
    2045                 2050                 2055             


Ser Gly  Ser Thr Tyr Phe His  Met Ala Leu Gly Ser  Leu Gly Arg 
    2060                 2065                 2070             


Gly Ser  Arg Leu Leu Cys Glu  Thr Ser Leu Gly Tyr  Lys Met Asp 
    2075                 2080                 2085             


Asp Leu  Leu Thr Ser Tyr Val  Gln Gln Leu Leu Ser  Ala Met Asn 
    2090                 2095                 2100             


Lys Gln  Arg Gly Ser Lys Ala  Pro Ala Leu Ala Ser  Thr 
    2105                 2110                 2115     


<210>  605
<211>  2130
<212>  DNA
<213>  Homosapiens

<400>  605
agcgggacgt gagctcgcga ccagcgcggg ggaggcgccc acacgcccgt cccgtcttgg     60

tgtctggccc caggcggccg cgcctcccct ccgaggtggt cgcatagccc ctgcaccagg    120

cggcccgcgc ccgcgacctc aaggcggctg ccccgcgcca tggcggcccg gctgggtgcg    180

ctggccgcgt cggggctgta ccggcggcgc cagcaccggc agagcccgcc gccagccacg    240

ggcaatatgt cggacgcctt ggccaacgcc gtgtgccagc gctgccaggc ccgcttctcc    300

cccgccgagc gcattgtcaa cagcaatggg gagctgtacc atgagcactg cttcgtgtgt    360

gcccagtgct tccggccctt ccccgagggg ctcttctatg agtttgaagg ccggaagtac    420

tgcgaacacg acttccaaat gctgtttgct ccgtgctgtg gatcctgcgg tgagttcatc    480

attggccgcg tcatcaaggc catgaacaac aactggcacc cgggctgctt ccgctgcgag    540

ctgtgtgatg tggagctggc tgacctgggc tttgtgaaga atgccggcag gcatctctgc    600

cggccttgcc acaaccgtga gaaggccaaa ggcctgggca agtacatctg ccagcggtgc    660

cacctggtca tcgacgagca gcccctcatg ttcaggagcg acgcctacca ccctgaccac    720

ttcaactgca cccactgtgg gaaggagctg acagccgagg cccgcgagct gaagggtgag    780

ctctactgcc tgccctgcca tgacaagatg ggcgtcccca tctgcggggc ctgccgccgg    840

cccatcgagg gccgagtggt caacgcgctg ggcaagcagt ggcacgtgga gcactttgtc    900

tgtgccaagt gtgagaagcc attcctgggg caccggcact atgagaagaa gggcctggcc    960

tactgcgaga ctcactacaa ccagctcttc ggggacgtct gctacaactg cagccatgtg   1020

attgaaggcg atgtggtgtc ggccctcaac aaggcctggt gtgtgagctg cttctcctgc   1080

tccacctgca acagcaagct caccctgaag aacaagtttg tggagttcga catgaagccc   1140

gtgtgtaaga ggtgctacga gaagttcccg ctggagctga agaagcggct gaagaagctg   1200

tcggagctga cctcccgcaa ggcccagccc aaggccacag acctcaactc tgcctgaagg   1260

ccctcttgcg cagctgcctc tcggcccctc cgccttctcc cctcctgctg tccatgcttg   1320

gccccctcgt ccccatccac ctgtgccctc cgcatcttac cctccctttc tctttcctca   1380

ttgccttctc ccttcctgtt ccctcatctc tgccttcccc atgtctctcc tctccttggc   1440

cgtggcttct gtctgtgagg aggcaggagc tggggagtgg gagcctatga ccccacgtct   1500

gacagccatg tccacctgtg cccacagctt ccgcccacag acctccaggg acaggagcaa   1560

attgcaccac agctccccgc ctggcctggc cctccccagg cggctcagtg gctcatgctg   1620

tcctgtgaga gcccctgccc cagagcggcc ccactaagcg catgtggctc ctgggctacc   1680

cacagccagg gcagcctgct ggagccacag ggccagggcc atgcagatgg aggcctctgg   1740

gagccacctc caatccctca ccactcactc aaccagtggc acagtgtcct tgtgcccaca   1800

ctgagccagc aagtcctgct gtccacaccc acaagctacc tggagggaca ggacccacct   1860

ccatccttcg gaaggccttc ctggaatccc accttggcct ccgccctcgg ttccgccccg   1920

cccctctccc cccgaccttg gggcttgtgt cgagcccttg ggtggggcca ggaggaggtg   1980

atggcgtcag aggaggtgtg gtcagaggtg acttgttccc acctccaggg aggacgcttc   2040

gtcttcggcc agcgcagacc tggtgtttgt ttgttgggct cacgcttgca caatgaaggc   2100

ttgttcacac aaaaaaaaaa aaaaaaaaaa                                    2130


<210>  606
<211>  365
<212>  PRT
<213>  Homosapiens

<400>  606

Met Ala Ala Arg Leu Gly Ala Leu Ala Ala Ser Gly Leu Tyr Arg Arg 
1               5                   10                  15      


Arg Gln His Arg Gln Ser Pro Pro Pro Ala Thr Gly Asn Met Ser Asp 
            20                  25                  30          


Ala Leu Ala Asn Ala Val Cys Gln Arg Cys Gln Ala Arg Phe Ser Pro 
        35                  40                  45              


Ala Glu Arg Ile Val Asn Ser Asn Gly Glu Leu Tyr His Glu His Cys 
    50                  55                  60                  


Phe Val Cys Ala Gln Cys Phe Arg Pro Phe Pro Glu Gly Leu Phe Tyr 
65                  70                  75                  80  


Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln Met Leu Phe 
                85                  90                  95      


Ala Pro Cys Cys Gly Ser Cys Gly Glu Phe Ile Ile Gly Arg Val Ile 
            100                 105                 110         


Lys Ala Met Asn Asn Asn Trp His Pro Gly Cys Phe Arg Cys Glu Leu 
        115                 120                 125             


Cys Asp Val Glu Leu Ala Asp Leu Gly Phe Val Lys Asn Ala Gly Arg 
    130                 135                 140                 


His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Lys Gly Leu Gly 
145                 150                 155                 160 


Lys Tyr Ile Cys Gln Arg Cys His Leu Val Ile Asp Glu Gln Pro Leu 
                165                 170                 175     


Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn Cys Thr His 
            180                 185                 190         


Cys Gly Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys Gly Glu Leu 
        195                 200                 205             


Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile Cys Gly Ala 
    210                 215                 220                 


Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu Gly Lys Gln 
225                 230                 235                 240 


Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe Leu 
                245                 250                 255     


Gly His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys Glu Thr His 
            260                 265                 270         


Tyr Asn Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser His Val Ile 
        275                 280                 285             


Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Ser Cys 
    290                 295                 300                 


Phe Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys Asn Lys Phe 
305                 310                 315                 320 


Val Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr Glu Lys Phe 
                325                 330                 335     


Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu Leu Thr Ser 
            340                 345                 350         


Arg Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
        355                 360                 365 


<210>  607
<211>  2070
<212>  DNA
<213>  Homosapiens

<400>  607
ccgacaccca cgggcggaga tcacctgctg ccccgcagac ccctgtccct tcctcccgga     60

ccagcagcta gaggatgtcc aaacggagtt ggtgggctgg atccagaaag cccccaagag    120

agatgctgaa actctcaggc tctgactcca gccaaagcat gaatggcctt gaagtggctc    180

ccccaggtct gatcaccaac ttctccctgg ccacggcaga gcaatgtggc caggagacgc    240

cactggagaa catgctgttc gcctccttct accttctgga ttttatcctg gctttagttg    300

gcaataccct ggctctgtgg cttttcatcc gagaccacaa gtccgggacc ccggccaacg    360

tgttcctgat gcatctggcc gtggccgact tgtcgtgcgt gctggtcctg cccacccgcc    420

tggtctacca cttctctggg aaccactggc catttgggga aatcgcatgc cgtctcaccg    480

gcttcctctt ctacctcaac atgtacgcca gcatctactt cctcacctgc atcagcgccg    540

accgtttcct ggccattgtg cacccggtca agtccctcaa gctccgcagg cccctctacg    600

cacacctggc ctgtgccttc ctgtgggtgg tggtggctgt ggccatggcc ccgctgctgg    660

tgagcccaca gaccgtgcag accaaccaca cggtggtctg cctgcagctg taccgggaga    720

aggcctccca ccatgccctg gtgtccctgg cagtggcctt caccttcccg ttcatcacca    780

cggtcacctg ctacctgctg atcatccgca gcctgcggca gggcctgcgt gtggagaagc    840

gcctcaagac caaggcagtg cgcatgatcg ccatagtgct ggccatcttc ctggtctgct    900

tcgtgcccta ccacgtcaac cgctccgtct acgtgctgca ctaccgcagc catggggcct    960

cctgcgccac ccagcgcatc ctggccctgg caaaccgcat cacctcctgc ctcaccagcc   1020

tcaacggggc actcgacccc atcatgtatt tcttcgtggc tgagaagttc cgccacgccc   1080

tgtgcaactt gctctgtggc aaaaggctca agggcccgcc ccccagcttc gaagggaaaa   1140

ccaacgagag ctcgctgagt gccaagtcag agctgtgagc ggggggcgcc gtccaggccg   1200

agcgcagact gtttaggact cagcagaccc agcaagaggc atctgccctt tccccagcca   1260

cctccccagc aagcaacctg aaatctcagc agatgcccac catttctcta gatcgcctag   1320

tctcaaccca taaaaaggaa gaactgacaa aggggatcca tcggccaccc ctctgcaggg   1380

gcttgtgatg gctacaatgg ctcctagaca ctcaacgact tcatctgtgg cagggagaga   1440

ggaggccgga agaacaaccc ctgaacaatg gaggcctttc tttcccgcta ggctcccagc   1500

ctccttcccg ctacagaatc gctcatcggc gaggctcagc agaaagaccc tgaaggcagg   1560

ctgcaaatga cccagaagag ggacctggga gtcctggtgg ggacggggag ggagtctcaa   1620

tactcctttg cagcgcaagg tactctgagt cccctctgta gtgcctctgc cagacacaca   1680

ctgcctgagt tgaagagaca caggccacac atttcaggct ggttgccagc ggacgtcagc   1740

actcacggcc tgcggggact cagcacagct ctggattctg gatctctcct gctgtaaccc   1800

cacgcacaag cctgcaaccc ccagagctct ttgacaggct cccaggcctc ccagtcctgg   1860

acaagcatgt gcagtcacgg gagctcagct caggccaggg ctgggctgtg cacctgcctc   1920

ccactgaccc agacccactt cctccagaga ggcctctctc cgcctgagct atttcccttg   1980

ctagtgtgca gatatttccc taacatgtcc ttttttgtat ttgtttgtac ggaccataaa   2040

tataactgta gctttaagac taaaaaaaaa                                    2070


<210>  608
<211>  367
<212>  PRT
<213>  Homosapiens

<400>  608

Met Ser Lys Arg Ser Trp Trp Ala Gly Ser Arg Lys Pro Pro Arg Glu 
1               5                   10                  15      


Met Leu Lys Leu Ser Gly Ser Asp Ser Ser Gln Ser Met Asn Gly Leu 
            20                  25                  30          


Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser Leu Ala Thr Ala 
        35                  40                  45              


Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met Leu Phe Ala Ser 
    50                  55                  60                  


Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly Asn Thr Leu Ala 
65                  70                  75                  80  


Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr Pro Ala Asn Val 
                85                  90                  95      


Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys Val Leu Val Leu 
            100                 105                 110         


Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His Trp Pro Phe Gly 
        115                 120                 125             


Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr Leu Asn Met Tyr 
    130                 135                 140                 


Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp Arg Phe Leu Ala 
145                 150                 155                 160 


Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg Pro Leu Tyr Ala 
                165                 170                 175     


His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala Val Ala Met Ala 
            180                 185                 190         


Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn His Thr Val Val 
        195                 200                 205             


Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His Ala Leu Val Ser 
    210                 215                 220                 


Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr Val Thr Cys Tyr 
225                 230                 235                 240 


Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg Val Glu Lys Arg 
                245                 250                 255     


Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val Leu Ala Ile Phe 
            260                 265                 270         


Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser Val Tyr Val Leu 
        275                 280                 285             


His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln Arg Ile Leu Ala 
    290                 295                 300                 


Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu Asn Gly Ala Leu 
305                 310                 315                 320 


Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe Arg His Ala Leu 
                325                 330                 335     


Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro Pro Pro Ser Phe 
            340                 345                 350         


Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys Ser Glu Leu 
        355                 360                 365         


<210>  609
<211>  2824
<212>  DNA
<213>  Homosapiens

<400>  609
gaactttttt aaaaattaaa tttttatttt gagatcactg tttgtgttca gttgtaagaa     60

acaagagaga ttctgtgtac cctttaccca ttcctccatg ttgcaaaact agcacaatat    120

caccgccacg gtagacgcag tgaggccata agacatttcc gtcagcaaaa gggtcacttc    180

ttgtgcccct ttagaaccac acccacccct gccttccaac tattaatgct ggcaggactt    240

agccagaccg caagggcgcc tactccgaac aaggaagagg gtcaggcgct gggagggcga    300

ctgcaagcgg acaggcagca cctgcgacca cggtacttgg ggacaccaca aaagtccgca    360

gagcaggcac cgcggcactt ccgcgagcgc cgcaggccct gcccctttcg ccgtcgccga    420

ccaattgccg cccgaagacc gaaccgcttc agcggagggc cggaagtgag ccgcagcttt    480

tcctttctgc caccgccttg tccaagatgg cggacctcca ccgccagctg caggagtacc    540

tggcgcaggg gaaagctggc ggcccggcgg ccgcggagcc gctgctcgcc gcggagaagg    600

cggaggagcc cggggaccgg ccggcggagg agtggctggg ccgcgcgggc ttgcgctgga    660

cgtgggcgcg gagccctgcg gagtcggcag cggccggcct gacgtgcctc ccgagcgtga    720

cgcgcgggca gcggctggcg gcgggcggcg ggtgcctgct gctggctgca ctgtgtttcg    780

gcctagccgc gctctacgca ccggtgttgc tgctgcgcgc gcgcaagttc gcgctgctct    840

ggtcactggg ctcggcgctg gcgttggcgg gaagcgcgct gctgcggggc ggcgcggcgt    900

gcggacgcct gctgcgctgc gaagaagcgc cgtcccggcc cgcgctgctc tacatggcag    960

cgctgggcgc cacgctgttc gccgcgctgg gccttcgcag cacgctgctc acggtgctgg   1020

gcgcgggcgc gcaggtggcc gcgctgctgg ccgcgctggt tgggctgctg ccctggggcg   1080

gcggcaccgc gctgcgcctc gcactgggtc gcctgggccg cggcgccggc ctcgccaagg   1140

tgctgcccgt gtgaggacct cgcgccctcg ccgctgggga agtacgcgga gccagcgccg   1200

tcggagaccg cgccggccga gctgaggact gcacgccgct gtgcggaagc ccgtggcgaa   1260

ggccctgccc taacagcctg cgagtctaat ccgggagcgg ctgctgccag cggaggcgac   1320

agcagcgttg ggagctcctc gatgtcagct ttttgtgctg gacttggcac acgctctgaa   1380

aactgagatt ttgtcattga actggtgaca ggatgtgaga cggttattag aagttgcttt   1440

cgaagtaact gtggtcttag gttcggctga gtaaagaaaa aggatttttc ttcgagttag   1500

ctgctcttgt gatttttctc aggctgtttt gtcattttaa aatccagtgg tagatgtagc   1560

ttagcgacgg tagttttttg ttttggctat actaagactt ggaaattatt ctctccagtg   1620

tcagcgaatc cagaagggta tcagattaaa caccgaattc agccactgga cttttaaaag   1680

tacttaagat ggtttatctc gggttttttc ttcagttaac aaaatcataa atatggtgcc   1740

ttataacatg aaaggaaaat tagttgtgta tttcacgacg aaagcgacgg accaaaagaa   1800

atttcctgcc ccaagaagca tgggatccag gaaggggcgc gtagatgctt aacggtctct   1860

tcggaaatcc tgcaaataga aagataattc tagatccgga atacctgtat ctggtggaaa   1920

ccatggattt ctacaagctc gaattattcc tcattgtata gcctgctttg taaactagtt   1980

tacaatttgc aggctgatct taagattttt ttatatctaa ttgctgctgc cttcatttta   2040

ggttcagcag ttacttttaa ctaccttaat ttattgccag aaggtatgag cctaacattc   2100

tgatgagtcc agaaaactac gttttgtcag tagcaataca ctaggaagta aaatatattt   2160

agaatttaaa cattgtgtgc cagtggtcct cgcgcttgac tgcacatcag ttacttgaag   2220

agccacacct cagatcaatg cagtcagaac ctgggaagta ggtcccagac atcaggacct   2280

ttttaaagct ccccaagtga ttctacgttc cccaagtttg aggaccactt ttctgtgcat   2340

tggcttgcac aatttgaaaa taatgctttt cctgagctgg atcccagtgt tgccttaaca   2400

gggtgtctgt cgtgccgcag tagagcactg ctgcttcctc caaccccaaa atttatgttc   2460

ctaagtaagt caggtcccta agccccgtcc caagaagtga cacaagtggc caacatccac   2520

actgtaggct tgcaggctac ccgccctgag atttggtaaa gaacactgcc ttgttcccca   2580

tcagtaaaca aggttaccta cctcaggagg ctgcttgtga gagagcaaat gcagtatctt   2640

cagaatgatt tattttttta attaattgta aagacttgtg ccattggctg ctctttctag   2700

tcccctaaat ttctgttcta gttttaaatt tctctagaac ttgcaatagt tgggggtttt   2760

ataatgatgt tttacaatgt ttatttctta aataaaaact taaaaattca aaaaaaaaaa   2820

aaaa                                                                2824


<210>  610
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  610

Met Ala Asp Leu His Arg Gln Leu Gln Glu Tyr Leu Ala Gln Gly Lys 
1               5                   10                  15      


Ala Gly Gly Pro Ala Ala Ala Glu Pro Leu Leu Ala Ala Glu Lys Ala 
            20                  25                  30          


Glu Glu Pro Gly Asp Arg Pro Ala Glu Glu Trp Leu Gly Arg Ala Gly 
        35                  40                  45              


Leu Arg Trp Thr Trp Ala Arg Ser Pro Ala Glu Ser Ala Ala Ala Gly 
    50                  55                  60                  


Leu Thr Cys Leu Pro Ser Val Thr Arg Gly Gln Arg Leu Ala Ala Gly 
65                  70                  75                  80  


Gly Gly Cys Leu Leu Leu Ala Ala Leu Cys Phe Gly Leu Ala Ala Leu 
                85                  90                  95      


Tyr Ala Pro Val Leu Leu Leu Arg Ala Arg Lys Phe Ala Leu Leu Trp 
            100                 105                 110         


Ser Leu Gly Ser Ala Leu Ala Leu Ala Gly Ser Ala Leu Leu Arg Gly 
        115                 120                 125             


Gly Ala Ala Cys Gly Arg Leu Leu Arg Cys Glu Glu Ala Pro Ser Arg 
    130                 135                 140                 


Pro Ala Leu Leu Tyr Met Ala Ala Leu Gly Ala Thr Leu Phe Ala Ala 
145                 150                 155                 160 


Leu Gly Leu Arg Ser Thr Leu Leu Thr Val Leu Gly Ala Gly Ala Gln 
                165                 170                 175     


Val Ala Ala Leu Leu Ala Ala Leu Val Gly Leu Leu Pro Trp Gly Gly 
            180                 185                 190         


Gly Thr Ala Leu Arg Leu Ala Leu Gly Arg Leu Gly Arg Gly Ala Gly 
        195                 200                 205             


Leu Ala Lys Val Leu Pro Val 
    210                 215 


<210>  611
<211>  1174
<212>  DNA
<213>  Homosapiens

<400>  611
agagcgtgcg ttcggtggcc cataggggaa gatggcggct gctcctttgg aggagcggga     60

ttgagaggat cggggtgggg agaccaaaca agagagacat ttctggctct gaaggcgaac    120

gcttcgctgg ccatttagga gctctgctca aagccagacg tatcctagaa ggaaaacatc    180

accatggcta cagaaattgg ttctcctcct cgttttttcc atatgccaag gttccagcac    240

caggcacctc gacagctgtt ttataagcga cctgattttg cacaacagca agcaatgcaa    300

cagcttactt ttgatggaaa acgaatgaga aaagctgtga accgaaaaac catagactac    360

aatccatctg taattaagta tttggagaac agaatatggc aaagagacca gagagatatg    420

cgggcaattc agcctgatgc aggttattac aatgatctgg tcccacctat aggaatgttg    480

aataatccta tgaatgcagt aacaacaaaa tttgttcgga catcaacaaa taaagtaaag    540

tgtcctgtat ttgttgttag gtggactcca gaaggaagac gcttggtcac tggagcttct    600

agtggggagt ttaccctgtg gaatggactc actttcaatt ttgaaacaat attacaggct    660

cacgacagcc cagtgagggc catgacgtgg tcacataatg acatgtggat gttgacagca    720

gaccacggag gatatgtgaa atattggcag tcgaacatga acaacgtcaa gatgttccag    780

gcacataagg aggcgattag agaggccagg tttatacaca atataccatt ttctgtagtc    840

cctattgtca tggttaaatt attctctaag tgtattctgg gtgcagagat gcatgggctc    900

tgtcagtttc tgggaaactt tctgcaccct ataaacacaa tatttttctt tgttttcaca    960

cattcaccat tttgctggca cctttctgaa gtagtgttgt cccggtatca gcctttgcaa   1020

tatgttagag atgtactgtc tgccgcattt tgcactggtt ttctcttttc atttatgatt   1080

aataatgtgt atacgttatt cctttttatt atctactgtg taagacaaga atatttcatt   1140

ccaaataaag aattcagtct ttaattatga aaaa                               1174


<210>  612
<211>  326
<212>  PRT
<213>  Homosapiens

<400>  612

Met Ala Thr Glu Ile Gly Ser Pro Pro Arg Phe Phe His Met Pro Arg 
1               5                   10                  15      


Phe Gln His Gln Ala Pro Arg Gln Leu Phe Tyr Lys Arg Pro Asp Phe 
            20                  25                  30          


Ala Gln Gln Gln Ala Met Gln Gln Leu Thr Phe Asp Gly Lys Arg Met 
        35                  40                  45              


Arg Lys Ala Val Asn Arg Lys Thr Ile Asp Tyr Asn Pro Ser Val Ile 
    50                  55                  60                  


Lys Tyr Leu Glu Asn Arg Ile Trp Gln Arg Asp Gln Arg Asp Met Arg 
65                  70                  75                  80  


Ala Ile Gln Pro Asp Ala Gly Tyr Tyr Asn Asp Leu Val Pro Pro Ile 
                85                  90                  95      


Gly Met Leu Asn Asn Pro Met Asn Ala Val Thr Thr Lys Phe Val Arg 
            100                 105                 110         


Thr Ser Thr Asn Lys Val Lys Cys Pro Val Phe Val Val Arg Trp Thr 
        115                 120                 125             


Pro Glu Gly Arg Arg Leu Val Thr Gly Ala Ser Ser Gly Glu Phe Thr 
    130                 135                 140                 


Leu Trp Asn Gly Leu Thr Phe Asn Phe Glu Thr Ile Leu Gln Ala His 
145                 150                 155                 160 


Asp Ser Pro Val Arg Ala Met Thr Trp Ser His Asn Asp Met Trp Met 
                165                 170                 175     


Leu Thr Ala Asp His Gly Gly Tyr Val Lys Tyr Trp Gln Ser Asn Met 
            180                 185                 190         


Asn Asn Val Lys Met Phe Gln Ala His Lys Glu Ala Ile Arg Glu Ala 
        195                 200                 205             


Arg Phe Ile His Asn Ile Pro Phe Ser Val Val Pro Ile Val Met Val 
    210                 215                 220                 


Lys Leu Phe Ser Lys Cys Ile Leu Gly Ala Glu Met His Gly Leu Cys 
225                 230                 235                 240 


Gln Phe Leu Gly Asn Phe Leu His Pro Ile Asn Thr Ile Phe Phe Phe 
                245                 250                 255     


Val Phe Thr His Ser Pro Phe Cys Trp His Leu Ser Glu Val Val Leu 
            260                 265                 270         


Ser Arg Tyr Gln Pro Leu Gln Tyr Val Arg Asp Val Leu Ser Ala Ala 
        275                 280                 285             


Phe Cys Thr Gly Phe Leu Phe Ser Phe Met Ile Asn Asn Val Tyr Thr 
    290                 295                 300                 


Leu Phe Leu Phe Ile Ile Tyr Cys Val Arg Gln Glu Tyr Phe Ile Pro 
305                 310                 315                 320 


Asn Lys Glu Phe Ser Leu 
                325     


<210>  613
<211>  3574
<212>  DNA
<213>  Homosapiens

<400>  613
agagcgtgcg ttcggtggcc cataggggaa gatggcggct gctcctttgg aggagcggga     60

ttgagaggat cggggtgggg agaccaaaca agagagacat ttctggctct gaaggcgaac    120

gcttcgctgg ccatttagga gctctgctca aagccagacg tatcctagaa ggaaaacatc    180

accatggcta cagaaattgg ttctcctcct cgttttttcc atatgccaag gttccagcac    240

caggcacctc gacagctgtt ttataagcga cctgattttg cacaacagca agcaatgcaa    300

cagcttactt ttgatggaaa acgaatgaga aaagctgtga accgaaaaac catagactac    360

aatccatctg taattaagta tttggagaac agaatatggc aaagagacca gagagatatg    420

cgggcaattc agcctgatgc aggttattac aatgatctgg tcccacctat aggaatgttg    480

aataatccta tgaatgcagt aacaacaaaa tttgttcgga catcaacaaa taaagtaaag    540

tgtcctgtat ttgttgttag gtggactcca gaaggaagac gcttggtcac tggagcttct    600

agtggggagt ttaccctgtg gaatggactc actttcaatt ttgaaacaat attacaggct    660

cacgacagcc cagtgagggc catgacgtgg tcacataatg acatgtggat gttgacagca    720

gaccacggag gatatgtgaa atattggcag tcgaacatga acaacgtcaa gatgttccag    780

gcacataagg aggcgattag agaggccagt ttctcaccca cggataataa atttgctaca    840

tgctctgatg acggcactgt tagaatctgg gactttcttc gttgccatga ggaaagaatt    900

ctccgagata catgttttca tcactgccgt tgttacttcc tttctgtcaa gaggtgaata    960

acagtaggtg gacaaagttt agggagccac atttaccaac ttctgtgaat atacccaaga   1020

agattctggc aaaacataga ttcaaattac agttgatgct gtggatggct atgggttaac   1080

tactcttcta ctttgacacg gattatttgt tgcttttatg tttctaaatt ctcaattaaa   1140

aagaagtgta tccttaatct ggccaactga aagtgaactt gttcattcac ctctaccttg   1200

ctttcaaaag gactgcttac catggaagtg ctccagaaga atcatttgaa acatcttttg   1260

ttttccttct tggttctgcg ttttcttcct taccaggggc ttcagtcatg gcttctcttt   1320

attcttggcc tgggttgtct gctggcacta atacatctat tattaacgta gtgtaggtac   1380

tggcctttct aatagtcttg gtatttagtg ccagactccc atcaatcttt tgaatgtctt   1440

ttctttttct ttttgcactt ttctagcttt tcaagtgatg actatatact gcttttcttg   1500

actgtatata ttgttactga attgtgaata tctgcagaaa tgtttactag agaacctgtg   1560

actgttgaat aacatgtgcc cgaacataca cacacacata tgtacacaca cacctcagag   1620

tactctttct tacagcggac tttgctgctg ctttctgcat gtgtgggaca ctggtatctc   1680

ccgtctcaga caaatggctg atgttctcta tgatattggt gttaatatca aagaattgaa   1740

tgaatacaac agaattgagg ttgaaaaata tttgattgcc acattccttt aagcatcttt   1800

gatgaatact ctgcaaagta gcctttaaaa aaatgtaaat tttttaaaaa gtccacagag   1860

gagaatttgc tggttagcac aaaacatact gcaaaattgc ttctttctgg ttattataac   1920

tgaagaatat agaagattga cacacatttt atacaccctc aggcagtgtt ttggaataat   1980

attgtacctt ttcaaattgt tatcaattaa ctgtttttct ccatttcata attctcaaga   2040

tttttctaaa tacagccttt aaatttgact caaatggaaa ttgtgcactt tcctgtttat   2100

acccttcccc acgttattgt aaaagagttt aacagcagcc tgatatgtaa gtttcagcaa   2160

aacttatacc tgtatatgtt tttatttgac tcaaaaatta gatattttac catatagtca   2220

taagaatttg ctcactttga tgccagaagt acttaagaag ttacacggca ctaattttat   2280

gagttgtatg cctaatttca atttctaacc tatttgacag tttcttttag gtcagccttt   2340

gttggtcttc catgtaaata caagttggta caaatcaata gaaaccattt tacctacata   2400

ggcaaagtaa atgtgtgact tagagactgc cagatttatg gtgcatctac ctttttatcc   2460

atttgagctt gcttttttat gtttgtgtat tggttgctcc tgacactata catttcaaaa   2520

ttttttataa cttgaaaaac acttctgtgc taccactcag ttctgatcaa atccttacat   2580

tttgcaacac tcatttctga attttcagta aagaaataca cattacaaat taaaggttaa   2640

aggccccttt acatgccctt ccccagtctc ctcttcctcc cccggaagtg tccattctgc   2700

tgaattcagg ttcatcattg ccagacaaat gtagtaagct agtgtttcac atttccaaaa   2760

tcagccttct ggcagacttg gaagtactct tgagaaaaga agactcgtga ccaaattctc   2820

ccacagattt gtaataatgt acatattgaa aggactgaag gctctcagac tgggaaagaa   2880

acttacccat tttaaaattc agcattgctc aacttacctg actgccggac cccttcaccc   2940

atgattctat gcactgtatt gttggaacat acattgtgaa aacactgccc tgcctaggca   3000

tacccccttt ccagaattaa ctttccattt aattctatag tttttcactg atgtaacttt   3060

ctagactgga caacaaagat gactaatagt aatcactcca agttgatgtt gactgttggg   3120

ttgtggtgaa atcattttgc attaaaggaa ggtaaaatac taataaattg catattcctt   3180

gaccagagca cagattactt atgcttctta attttttaaa atcttaaatc ctctgtccaa   3240

ctggagtatc tggctatggg ccatgggtac tcatataccc tttgtcttaa actgatctgt   3300

tacattttat gttcttgtgg ctagaagtag cctgagtttg ctgttaatgt ttaacacatt   3360

ttcttgagta acagttctgt taatattgta caagatggta cttgaattct ttgtttgcct   3420

tttttcttcc tgtattagaa aatcttggtg ctttttataa gttttgtata aaagaatttt   3480

ttttaagatt tgttcataaa atggtctgat ccaggaaaaa taaaatggga acatggacac   3540

catttctgac cttcaaataa aacttattat gtat                               3574


<210>  614
<211>  257
<212>  PRT
<213>  Homosapiens

<400>  614

Met Ala Thr Glu Ile Gly Ser Pro Pro Arg Phe Phe His Met Pro Arg 
1               5                   10                  15      


Phe Gln His Gln Ala Pro Arg Gln Leu Phe Tyr Lys Arg Pro Asp Phe 
            20                  25                  30          


Ala Gln Gln Gln Ala Met Gln Gln Leu Thr Phe Asp Gly Lys Arg Met 
        35                  40                  45              


Arg Lys Ala Val Asn Arg Lys Thr Ile Asp Tyr Asn Pro Ser Val Ile 
    50                  55                  60                  


Lys Tyr Leu Glu Asn Arg Ile Trp Gln Arg Asp Gln Arg Asp Met Arg 
65                  70                  75                  80  


Ala Ile Gln Pro Asp Ala Gly Tyr Tyr Asn Asp Leu Val Pro Pro Ile 
                85                  90                  95      


Gly Met Leu Asn Asn Pro Met Asn Ala Val Thr Thr Lys Phe Val Arg 
            100                 105                 110         


Thr Ser Thr Asn Lys Val Lys Cys Pro Val Phe Val Val Arg Trp Thr 
        115                 120                 125             


Pro Glu Gly Arg Arg Leu Val Thr Gly Ala Ser Ser Gly Glu Phe Thr 
    130                 135                 140                 


Leu Trp Asn Gly Leu Thr Phe Asn Phe Glu Thr Ile Leu Gln Ala His 
145                 150                 155                 160 


Asp Ser Pro Val Arg Ala Met Thr Trp Ser His Asn Asp Met Trp Met 
                165                 170                 175     


Leu Thr Ala Asp His Gly Gly Tyr Val Lys Tyr Trp Gln Ser Asn Met 
            180                 185                 190         


Asn Asn Val Lys Met Phe Gln Ala His Lys Glu Ala Ile Arg Glu Ala 
        195                 200                 205             


Ser Phe Ser Pro Thr Asp Asn Lys Phe Ala Thr Cys Ser Asp Asp Gly 
    210                 215                 220                 


Thr Val Arg Ile Trp Asp Phe Leu Arg Cys His Glu Glu Arg Ile Leu 
225                 230                 235                 240 


Arg Asp Thr Cys Phe His His Cys Arg Cys Tyr Phe Leu Ser Val Lys 
                245                 250                 255     


Arg 
    


<210>  615
<211>  6299
<212>  DNA
<213>  Homosapiens

<400>  615
agagcgtgcg ttcggtggcc cataggggaa gatggcggct gctcctttgg aggagcggga     60

ttgagaggat cggggtgggg agaccaaaca agagagacat ttctggctct gaaggcgaac    120

gcttcgctgg ccatttagga gctctgctca aagccagacg tatcctagaa ggaaaacatc    180

accatggcta cagaaattgg ttctcctcct cgttttttcc atatgccaag gttccagcac    240

caggcacctc gacagctgtt ttataagcga cctgattttg cacaacagca agcaatgcaa    300

cagcttactt ttgatggaaa acgaatgaga aaagctgtga accgaaaaac catagactac    360

aatccatctg taattaagta tttggagaac agaatatggc aaagagacca gagagatatg    420

cgggcaattc agcctgatgc aggttattac aatgatctgg tcccacctat aggaatgttg    480

aataatccta tgaatgcagt aacaacaaaa tttgttcgga catcaacaaa taaagtaaag    540

tgtcctgtat ttgttgttag gtggactcca gaaggaagac gcttggtcac tggagcttct    600

agtggggagt ttaccctgtg gaatggactc actttcaatt ttgaaacaat attacaggct    660

cacgacagcc cagtgagggc catgacgtgg tcacataatg acatgtggat gttgacagca    720

gaccacggag gatatgtgaa atattggcag tcgaacatga acaacgtcaa gatgttccag    780

gcacataagg aggcgattag agaggccagt ttctcaccca cggataataa atttgctaca    840

tgctctgatg acggcactgt tagaatctgg gactttcttc gttgccatga ggaaagaatt    900

ctccgagggc atggtgctga tgtgaaatgt gtagactggc atccaaccaa agggttagtt    960

gtttcaggaa gtaaagatag tcaacagcca atcaagttct gggatcccaa gactgggcag   1020

agtcttgcaa cacttcatgc ccataaaaac acagtaatgg aagtgaaatt aaacctcaat   1080

ggcaattggc tactcacagc atcacgtgat catctctgta aactttttga tatcagaaac   1140

ctaaaagaag agcttcaagt cttccgaggt cataagaaag aagccacagc tgtggcctgg   1200

catcctgttc atgaaggact ttttgccagt ggagggtctg atggttcttt gttattctgg   1260

catgttgggg tagagaagga agtgggtggg atggagatgg ctcacgaagg gatgatctgg   1320

agtctggctt ggcatcctct tgggcatatt ctctgctcag gctcaaatga ccatactagc   1380

aaattctgga ctcgaaaccg accaggtgat aaaatgcgag atcgatataa tctaaacctt   1440

ttacctggaa tgtctgaaga tggagtagaa tatgatgacc tcgaacctaa tagcctggca   1500

gtaattccag gaatgggaat accagaacaa ctaaaattag ctatggaaca agaacagatg   1560

gggaaagatg aatcaaatga aattgaaatg acaattccag gtttagattg gggaatggag   1620

gaagtgatgc aaaaggatca gaaaaaagta cctcagaaga aagttcctta tgcaaaaccc   1680

attcctgctc agttccagca ggcttggatg caaaataaag ttccaattcc tgctccaaat   1740

gaggtgctga atgacagaaa agaagacatt aaattggaag agaagaaaaa aacacaagca   1800

gaaattgagc aagaaatggc tacattacaa tatactaacc cacaacttct ggagcaactt   1860

aaaattgaaa gacttgcaca gaaacaagtt gagcaaattc agcctcctcc ctcatctggc   1920

acccctctcc tcggacccca gccttttcca ggacaaggtc caatgtctca gattcctcaa   1980

ggttttcaac agccccatcc atctcagcag atgccaatga acatggctca aatggggcct   2040

ccaggtccac agggacagtt taggcctcct ggaccccagg gacaaatggg accacaaggt   2100

cctccactgc atcagggagg tggggggcca caaggattca tgggaccaca ggggccccag   2160

ggcccgcccc aggggttgcc acggcctcag gacatgcatg ggccccaagg aatgcagagg   2220

catcctggac ctcatggccc tttgggacct caagggccac ctggaccaca aggtagttct   2280

ggtcctcaag gtcatatggg tcctcagggt ccacctggcc cacagggtca cataggcccc   2340

caaggcccgc ctggccctca gggtcacttg ggcccacagg ggcctccggg tactcaaggt   2400

atgcagggac cacctggtcc cagaggaatg caagggcctc ctcatcctca tgggatccaa   2460

ggcggaccag ggtctcaagg gatccaaggt cctgtgtctc agggacctct gatgggattg   2520

aatccaagag gaatgcaggg gcctccaggc ccccgggaga accagggtcc tgctccccaa   2580

gggatgatta tgggccaccc gcctcaagag atgagaggac ctcaccctcc aggtggacta   2640

ctgggacacg gccctcagga aatgagaggt cctcaggaga tccgaggcat gcaggggcct   2700

ccaccccaag gatcaatgct gggacctccc caggaattgc gagggcctcc aggctcacaa   2760

agtcagcagg ggccgcccca gggctcttta ggacctccac cccagggtgg catgcaagga   2820

ccccccggac ctcagggaca gcagaaccca gcaagagggc cacatccatc tcaagggcca   2880

ataccattcc agcaacagaa aacgcctctg ctaggtgatg ggccccgggc ccccttcaac   2940

caggaaggac agagcacagg ccccccaccc ctgataccag gcctagggca gcagggagca   3000

caaggtcgca ttccccctct gaaccccgga caaggacctg gccccaacaa aggtgactcc   3060

cgcggccctc caaaccatca catgggcccg atgtcagaga ggcggcatga gcagagcggc   3120

gggcctgagc atgggcccga gagggggcct ttccggggtg gccaggactg caggggtccc   3180

cctgataggc gtggccctca cccagacttc cccgatgact tcagcagacc agatgacttc   3240

caccctgaca agcgctttgg ccaccggtta cgtgaatttg aggggcgagg aggaccttta   3300

ccgcaagaag agaagtggag gcgagggggc cctgggcctc cgtttccccc tgatcacagg   3360

gaattcagcg agggggatgg ccggggtgca gcccgaggcc ctccgggggc atgggaaggc   3420

cgcaggcccg gagatgaacg tttcccccgg gatcccgagg acccacgttt tcgagggcgc   3480

agagaagaaa gtttcagaag aggagccccg ccgaggcatg agggccgtgc tccccccaga   3540

ggaagggatg gttttcctgg tcctgaagac tttggtccag aggagaattt tgatgcttct   3600

gaggaagcgg cccgaggacg agatctcaga ggtcgaggtc ggggtacccc acgaggagga   3660

aggaagggtt tacttcccac tcctgacgag ttccctcgct ttgaaggagg gcggaagcca   3720

gattcctggg atggaaacag agagcctggg ccaggtcatg aacattttcg tgatactccc   3780

cgccctgatc atccccctca cgacggtcat tccccagcca gcagagaacg ctcctcttct   3840

ctccaaggca tggacatggc atccctacct ccccgaaagc gcccctggca tgatggccca   3900

ggcacttctg agcacagaga gatggaggcc ccaggaggcc cttctgaaga ccgaggaggc   3960

aaaggccgag ggggcccagg acctgctcag agagtgccca aatctgggcg ttccagctcc   4020

ttagacggag agcaccacga tggataccac agagatgaac cttttggggg ccctccaggc   4080

agtggcaccc cttctcgagg gggccggagt ggcagtaact ggggtagagg gagtaacatg   4140

aactctggcc cgccgaggcg aggagcttca cggggtggtg gaaggggtcg gtagaagctg   4200

gaactgagta ccctgaggcc tctctggaca gtatgtaaga acttcttgtg gactcaccaa   4260

gagaaacaaa aggaagcctg caccattgta gccctgaact cttttctggg cacctgaatc   4320

ccaggaaccc tcaatgaggt cttcaagatg aagagactgc tgccagctac cagcctggct   4380

ggccctgtcc tgtccaccct cattgcccca actcccatgt tgttttgtga agataaaagc   4440

tgggatcttt ttcttttttt taagtctcac aagacatggg gcatctccac aaatttaagt   4500

tcctgtccat ttggaaattt gtttctatgt gtacagtttg tcagagaaaa acaaagtttt   4560

tgtatgaata cagaatgtga tttacgcaag aattgacaga aaactagttg tgaagtgctt   4620

gccttaagga aacctttggt ttccatcgca tcccatctgc caaggaatgc acggttgttg   4680

ctgatgttca tgagcatatt aaccactagg ttatctaaat taatctcagc tgtgaacttt   4740

gtgtttttca acacattctg tcacaccatt tttgtgacag aaaaatactt gaaaattatt   4800

ctaatgtagt ttgtagtagg ttcaaatttt tattcagaca tgctctgaca gatggaaaat   4860

tgtactctga agagaaaatg caatcttctg gatgtccaac gagggagctt ccccttggaa   4920

gcatctccta agaatcacag tttaggtttg aatcgccttg ttatgatgag gagaggaact   4980

tgatgttagt cagaaataaa gtcacatgcc ctttagataa cttgaaatca cacatggagt   5040

tgataaggaa tggaccaaaa taggtcctca aacaattttg caacacttaa ttaagttttc   5100

ctctcttcct cttccatact atgtggaaat accagtgtta cggcagggcg tacttctaac   5160

tcacagtaag ccagatagat cttgtccatg gcaaattcct tgtttaaaat aaacatacca   5220

tttagcccag tttggattgg aagccaaaaa ttcagtttgt tatatacccc atgatacttt   5280

ctatactgac ctttattttg gttttacatg gaagctttta ttaaaaggac tgtcctatgg   5340

ccaccttaac atttcattac attggcagct tcagttttgg catcagtcaa atttatttgg   5400

caaatttagt ggtgctggaa gtttcttttt ttcttttcct tttttgacag agtcttgctc   5460

tgtcacccag ccaggagtgc agtggtgcaa tcacggctca cttcagcttt gaccctgcct   5520

cagcctccct agtagctagg actacaggca tatgccacca tgcccagcta attttttgtg   5580

tgtgtgtttt ttgtagagat ggagtttcac cactttgtct atgctggttt caaactcctg   5640

ggctcaagcg gtccacctgc tgtggcctcc caaagtgctg ggattgcaga tctgagccac   5700

agtacctggc cgctggtgct ggaagtttca atggttgctt agaaaaggca tactgatata   5760

gtttaacagg atatgaaaat ttaactggtt ctctatgaat gtaaaaaaca gcaaaagcta   5820

attgatttct gtggagtgag aaaatgtcag ccatatacac tgcttttcag tgttagaatc   5880

tagagactat ttttttttta actttgaaat tacagcttat ttaatcagcg ctccaccata   5940

aacatgctat taggaggctc aagattgctt taggttatgg gtatttcttc actcaccccc   6000

aactggtata gcttaaagag agagaaactg taatcaaatt tcatgaagct aaaaccggat   6060

ccagagacca aacccatatc aagattagac tttttttccc tgagattcta gtggaaaaat   6120

tttcattatt ttgggcttta actttagaaa catagtatct cagtaagcag ataaccagat   6180

cacatttaaa aattttcatt ttaccttgaa gctctactgg acttgacaga tcacattttg   6240

agagtgaatt catttaaaca ataaacctct acattatact tataaaaaaa aaaaaaaaa    6299


<210>  616
<211>  1336
<212>  PRT
<213>  Homosapiens

<400>  616

Met Ala Thr Glu Ile Gly Ser Pro Pro Arg Phe Phe His Met Pro Arg 
1               5                   10                  15      


Phe Gln His Gln Ala Pro Arg Gln Leu Phe Tyr Lys Arg Pro Asp Phe 
            20                  25                  30          


Ala Gln Gln Gln Ala Met Gln Gln Leu Thr Phe Asp Gly Lys Arg Met 
        35                  40                  45              


Arg Lys Ala Val Asn Arg Lys Thr Ile Asp Tyr Asn Pro Ser Val Ile 
    50                  55                  60                  


Lys Tyr Leu Glu Asn Arg Ile Trp Gln Arg Asp Gln Arg Asp Met Arg 
65                  70                  75                  80  


Ala Ile Gln Pro Asp Ala Gly Tyr Tyr Asn Asp Leu Val Pro Pro Ile 
                85                  90                  95      


Gly Met Leu Asn Asn Pro Met Asn Ala Val Thr Thr Lys Phe Val Arg 
            100                 105                 110         


Thr Ser Thr Asn Lys Val Lys Cys Pro Val Phe Val Val Arg Trp Thr 
        115                 120                 125             


Pro Glu Gly Arg Arg Leu Val Thr Gly Ala Ser Ser Gly Glu Phe Thr 
    130                 135                 140                 


Leu Trp Asn Gly Leu Thr Phe Asn Phe Glu Thr Ile Leu Gln Ala His 
145                 150                 155                 160 


Asp Ser Pro Val Arg Ala Met Thr Trp Ser His Asn Asp Met Trp Met 
                165                 170                 175     


Leu Thr Ala Asp His Gly Gly Tyr Val Lys Tyr Trp Gln Ser Asn Met 
            180                 185                 190         


Asn Asn Val Lys Met Phe Gln Ala His Lys Glu Ala Ile Arg Glu Ala 
        195                 200                 205             


Ser Phe Ser Pro Thr Asp Asn Lys Phe Ala Thr Cys Ser Asp Asp Gly 
    210                 215                 220                 


Thr Val Arg Ile Trp Asp Phe Leu Arg Cys His Glu Glu Arg Ile Leu 
225                 230                 235                 240 


Arg Gly His Gly Ala Asp Val Lys Cys Val Asp Trp His Pro Thr Lys 
                245                 250                 255     


Gly Leu Val Val Ser Gly Ser Lys Asp Ser Gln Gln Pro Ile Lys Phe 
            260                 265                 270         


Trp Asp Pro Lys Thr Gly Gln Ser Leu Ala Thr Leu His Ala His Lys 
        275                 280                 285             


Asn Thr Val Met Glu Val Lys Leu Asn Leu Asn Gly Asn Trp Leu Leu 
    290                 295                 300                 


Thr Ala Ser Arg Asp His Leu Cys Lys Leu Phe Asp Ile Arg Asn Leu 
305                 310                 315                 320 


Lys Glu Glu Leu Gln Val Phe Arg Gly His Lys Lys Glu Ala Thr Ala 
                325                 330                 335     


Val Ala Trp His Pro Val His Glu Gly Leu Phe Ala Ser Gly Gly Ser 
            340                 345                 350         


Asp Gly Ser Leu Leu Phe Trp His Val Gly Val Glu Lys Glu Val Gly 
        355                 360                 365             


Gly Met Glu Met Ala His Glu Gly Met Ile Trp Ser Leu Ala Trp His 
    370                 375                 380                 


Pro Leu Gly His Ile Leu Cys Ser Gly Ser Asn Asp His Thr Ser Lys 
385                 390                 395                 400 


Phe Trp Thr Arg Asn Arg Pro Gly Asp Lys Met Arg Asp Arg Tyr Asn 
                405                 410                 415     


Leu Asn Leu Leu Pro Gly Met Ser Glu Asp Gly Val Glu Tyr Asp Asp 
            420                 425                 430         


Leu Glu Pro Asn Ser Leu Ala Val Ile Pro Gly Met Gly Ile Pro Glu 
        435                 440                 445             


Gln Leu Lys Leu Ala Met Glu Gln Glu Gln Met Gly Lys Asp Glu Ser 
    450                 455                 460                 


Asn Glu Ile Glu Met Thr Ile Pro Gly Leu Asp Trp Gly Met Glu Glu 
465                 470                 475                 480 


Val Met Gln Lys Asp Gln Lys Lys Val Pro Gln Lys Lys Val Pro Tyr 
                485                 490                 495     


Ala Lys Pro Ile Pro Ala Gln Phe Gln Gln Ala Trp Met Gln Asn Lys 
            500                 505                 510         


Val Pro Ile Pro Ala Pro Asn Glu Val Leu Asn Asp Arg Lys Glu Asp 
        515                 520                 525             


Ile Lys Leu Glu Glu Lys Lys Lys Thr Gln Ala Glu Ile Glu Gln Glu 
    530                 535                 540                 


Met Ala Thr Leu Gln Tyr Thr Asn Pro Gln Leu Leu Glu Gln Leu Lys 
545                 550                 555                 560 


Ile Glu Arg Leu Ala Gln Lys Gln Val Glu Gln Ile Gln Pro Pro Pro 
                565                 570                 575     


Ser Ser Gly Thr Pro Leu Leu Gly Pro Gln Pro Phe Pro Gly Gln Gly 
            580                 585                 590         


Pro Met Ser Gln Ile Pro Gln Gly Phe Gln Gln Pro His Pro Ser Gln 
        595                 600                 605             


Gln Met Pro Met Asn Met Ala Gln Met Gly Pro Pro Gly Pro Gln Gly 
    610                 615                 620                 


Gln Phe Arg Pro Pro Gly Pro Gln Gly Gln Met Gly Pro Gln Gly Pro 
625                 630                 635                 640 


Pro Leu His Gln Gly Gly Gly Gly Pro Gln Gly Phe Met Gly Pro Gln 
                645                 650                 655     


Gly Pro Gln Gly Pro Pro Gln Gly Leu Pro Arg Pro Gln Asp Met His 
            660                 665                 670         


Gly Pro Gln Gly Met Gln Arg His Pro Gly Pro His Gly Pro Leu Gly 
        675                 680                 685             


Pro Gln Gly Pro Pro Gly Pro Gln Gly Ser Ser Gly Pro Gln Gly His 
    690                 695                 700                 


Met Gly Pro Gln Gly Pro Pro Gly Pro Gln Gly His Ile Gly Pro Gln 
705                 710                 715                 720 


Gly Pro Pro Gly Pro Gln Gly His Leu Gly Pro Gln Gly Pro Pro Gly 
                725                 730                 735     


Thr Gln Gly Met Gln Gly Pro Pro Gly Pro Arg Gly Met Gln Gly Pro 
            740                 745                 750         


Pro His Pro His Gly Ile Gln Gly Gly Pro Gly Ser Gln Gly Ile Gln 
        755                 760                 765             


Gly Pro Val Ser Gln Gly Pro Leu Met Gly Leu Asn Pro Arg Gly Met 
    770                 775                 780                 


Gln Gly Pro Pro Gly Pro Arg Glu Asn Gln Gly Pro Ala Pro Gln Gly 
785                 790                 795                 800 


Met Ile Met Gly His Pro Pro Gln Glu Met Arg Gly Pro His Pro Pro 
                805                 810                 815     


Gly Gly Leu Leu Gly His Gly Pro Gln Glu Met Arg Gly Pro Gln Glu 
            820                 825                 830         


Ile Arg Gly Met Gln Gly Pro Pro Pro Gln Gly Ser Met Leu Gly Pro 
        835                 840                 845             


Pro Gln Glu Leu Arg Gly Pro Pro Gly Ser Gln Ser Gln Gln Gly Pro 
    850                 855                 860                 


Pro Gln Gly Ser Leu Gly Pro Pro Pro Gln Gly Gly Met Gln Gly Pro 
865                 870                 875                 880 


Pro Gly Pro Gln Gly Gln Gln Asn Pro Ala Arg Gly Pro His Pro Ser 
                885                 890                 895     


Gln Gly Pro Ile Pro Phe Gln Gln Gln Lys Thr Pro Leu Leu Gly Asp 
            900                 905                 910         


Gly Pro Arg Ala Pro Phe Asn Gln Glu Gly Gln Ser Thr Gly Pro Pro 
        915                 920                 925             


Pro Leu Ile Pro Gly Leu Gly Gln Gln Gly Ala Gln Gly Arg Ile Pro 
    930                 935                 940                 


Pro Leu Asn Pro Gly Gln Gly Pro Gly Pro Asn Lys Gly Asp Ser Arg 
945                 950                 955                 960 


Gly Pro Pro Asn His His Met Gly Pro Met Ser Glu Arg Arg His Glu 
                965                 970                 975     


Gln Ser Gly Gly Pro Glu His Gly Pro Glu Arg Gly Pro Phe Arg Gly 
            980                 985                 990         


Gly Gln Asp Cys Arg Gly Pro Pro  Asp Arg Arg Gly Pro  His Pro Asp 
        995                 1000                 1005             


Phe Pro  Asp Asp Phe Ser Arg  Pro Asp Asp Phe His  Pro Asp Lys 
    1010                 1015                 1020             


Arg Phe  Gly His Arg Leu Arg  Glu Phe Glu Gly Arg  Gly Gly Pro 
    1025                 1030                 1035             


Leu Pro  Gln Glu Glu Lys Trp  Arg Arg Gly Gly Pro  Gly Pro Pro 
    1040                 1045                 1050             


Phe Pro  Pro Asp His Arg Glu  Phe Ser Glu Gly Asp  Gly Arg Gly 
    1055                 1060                 1065             


Ala Ala  Arg Gly Pro Pro Gly  Ala Trp Glu Gly Arg  Arg Pro Gly 
    1070                 1075                 1080             


Asp Glu  Arg Phe Pro Arg Asp  Pro Glu Asp Pro Arg  Phe Arg Gly 
    1085                 1090                 1095             


Arg Arg  Glu Glu Ser Phe Arg  Arg Gly Ala Pro Pro  Arg His Glu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Pro Arg Gly  Arg Asp Gly Phe Pro  Gly Pro Glu 
    1115                 1120                 1125             


Asp Phe  Gly Pro Glu Glu Asn  Phe Asp Ala Ser Glu  Glu Ala Ala 
    1130                 1135                 1140             


Arg Gly  Arg Asp Leu Arg Gly  Arg Gly Arg Gly Thr  Pro Arg Gly 
    1145                 1150                 1155             


Gly Arg  Lys Gly Leu Leu Pro  Thr Pro Asp Glu Phe  Pro Arg Phe 
    1160                 1165                 1170             


Glu Gly  Gly Arg Lys Pro Asp  Ser Trp Asp Gly Asn  Arg Glu Pro 
    1175                 1180                 1185             


Gly Pro  Gly His Glu His Phe  Arg Asp Thr Pro Arg  Pro Asp His 
    1190                 1195                 1200             


Pro Pro  His Asp Gly His Ser  Pro Ala Ser Arg Glu  Arg Ser Ser 
    1205                 1210                 1215             


Ser Leu  Gln Gly Met Asp Met  Ala Ser Leu Pro Pro  Arg Lys Arg 
    1220                 1225                 1230             


Pro Trp  His Asp Gly Pro Gly  Thr Ser Glu His Arg  Glu Met Glu 
    1235                 1240                 1245             


Ala Pro  Gly Gly Pro Ser Glu  Asp Arg Gly Gly Lys  Gly Arg Gly 
    1250                 1255                 1260             


Gly Pro  Gly Pro Ala Gln Arg  Val Pro Lys Ser Gly  Arg Ser Ser 
    1265                 1270                 1275             


Ser Leu  Asp Gly Glu His His  Asp Gly Tyr His Arg  Asp Glu Pro 
    1280                 1285                 1290             


Phe Gly  Gly Pro Pro Gly Ser  Gly Thr Pro Ser Arg  Gly Gly Arg 
    1295                 1300                 1305             


Ser Gly  Ser Asn Trp Gly Arg  Gly Ser Asn Met Asn  Ser Gly Pro 
    1310                 1315                 1320             


Pro Arg  Arg Gly Ala Ser Arg  Gly Gly Gly Arg Gly  Arg 
    1325                 1330                 1335     


<210>  617
<211>  1909
<212>  DNA
<213>  Homosapiens

<400>  617
gctggtggtg gcgcgcggcg cggcgcggcg atggcggcgg gtggcagcga tccgcgggct     60

ggcgacgtag aggaggacgc ctcacagctc atctttccta aagagtttga aacagctgag    120

acacttctaa attcagaagt tcatatgctt ctggaacatc gaaagcagca gaatgagagt    180

gcagaggacg aacaggagct ctcagaagtc ttcatgaaaa cattaaacta cacagcccgt    240

ttcagtcgtt tcaaaaacag agagaccatt gccagtgttc gtagcttgct actccagaaa    300

aagcttcata agtttgagtt ggcctgtttg gccaaccttt gcccagagac tgctgaggag    360

tccaaggctc taatcccaag cttggaggga cggtttgaag atgaggagct gcagcagatt    420

cttgatgata tccagacaaa gcgcagcttt cagtattaat ctccaaacat cactgctgct    480

cggagaaacc acatccccag gcataacacc accttcccac tgtctggggc tgacttgcac    540

agaaattctg ttgaagacag ttgagaattc ctttggagaa aacagcccag cttggcgtgg    600

ggttaggttg ctgtttcaaa taactcacag gcccaggtga catggaatct tggagcagcc    660

ttgtgcagtg gcagccagtg gcttcctgaa cgtgcctctg cgaagtgtga gatgaggggt    720

cacataacca cactgttgac tacctcattc ctggtttttg gcctccacat catctttttt    780

cttaatattt catgttttaa tttcagggtg tttatacttt ttgaaactag accagaagat    840

agtagacttt atagagaaag accagtttta cctagatact aaaggaagaa ttaaaccgct    900

gttagtttga aatgcttttt tttttttttt ttaaatggag atagggtctt aactcttgtc    960

caggctggag gagtgcagtc gtacagtcat ggctcactga agtcttgacc ccgctgcctc   1020

agcctcccaa ataactgggg ccacaggtgt gcaccacaac tctcagctaa tttttaaaat   1080

tttttataga ggtggggttt tactatgctg tccagactgg tcttaaactc ctgggctcaa   1140

gtgatccccc tgccttggcc tcccaaactg gtgagattac aggcatgagc caccacaact   1200

ggcctgaaat tcttaaagga tgggagtgtc gatgacagca ccttggcatc gttgtgccta   1260

acctgggaga cggaagaagc acgccatggg aagtgtttac acttggggga caagtgctaa   1320

gtattgtgga gcccatagcc ccttgagata gatggctact ttgcctttct tcttgaactg   1380

tcttgcagaa tgtggatttg gggtaagtgg tcttgaagga ttcatttagt caccctcaaa   1440

ttaagatttt tacttcatct ttcttgggcc tgcacctcca agataacaaa gaagaagcaa   1500

tggtcgtgcc aaagaggtcc acaaccaggt gtgcactgtt cactgcagcc catttgctgt   1560

atgaactgtg gttgttgtgt gcccaatgac aaggctacta agaaattcat catttgaaac   1620

gtagaggccg cagcagtcag cgatgtttct gaaatgagca tccttgacgc ctgtgtactt   1680

cccaggctgg atgtgaagct acattaccat gtgagttgtg ccattcacag cacagtggtg   1740

aggaattgag ctcatgaagc aggcaaggac cgaacacctc caccccaacg tagacctgca   1800

ggtgctgccc catgacctcc accaaagccc atataaggag cggagttgtt aaggactgaa   1860

gaaaaacttc tctggagaaa aataaaattg caattctact taaaaaaaa               1909


<210>  618
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  618

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Glu Phe Glu Thr Ala Glu Thr Leu 
            20                  25                  30          


Leu Asn Ser Glu Val His Met Leu Leu Glu His Arg Lys Gln Gln Asn 
        35                  40                  45              


Glu Ser Ala Glu Asp Glu Gln Glu Leu Ser Glu Val Phe Met Lys Thr 
    50                  55                  60                  


Leu Asn Tyr Thr Ala Arg Phe Ser Arg Phe Lys Asn Arg Glu Thr Ile 
65                  70                  75                  80  


Ala Ser Val Arg Ser Leu Leu Leu Gln Lys Lys Leu His Lys Phe Glu 
                85                  90                  95      


Leu Ala Cys Leu Ala Asn Leu Cys Pro Glu Thr Ala Glu Glu Ser Lys 
            100                 105                 110         


Ala Leu Ile Pro Ser Leu Glu Gly Arg Phe Glu Asp Glu Glu Leu Gln 
        115                 120                 125             


Gln Ile Leu Asp Asp Ile Gln Thr Lys Arg Ser Phe Gln Tyr 
    130                 135                 140         


<210>  619
<211>  4698
<212>  DNA
<213>  Homosapiens

<400>  619
gttggtgaag agatcaggaa gagatttctt cgagactaag gatggatgac ccttagcaac     60

agtgaccgtc tcctcccggc atagcaagat ggcctgccct caggtacagg aagaaggaat    120

ggaatcggaa ggaagaaaat tcattccaga gacaaaatag ctcccctcct ctgttgtagc    180

tgttcctctg gcaatacaaa ctttctgctt tcaggttctg cagcattcca gaccttgagc    240

actgaatcag gatgggaaaa agacgttgtg ttcctccact cgagcccaag ttggcagcag    300

gctgttgtgg ggtcaagaag cccaaattat ctggaagtgg aacgcacagt cacgggaatc    360

agtccacaac tgtccccggc tctagttcag gacctcttca aaaccaccag catgtggaca    420

gcagcagtgg acgggagaat gtgtcagact taactctggg acctggaaac tctcccatca    480

cacgaatgaa tcccgcatcg ggagcgctga gccctcttcc ccggcctaat ggaactgcca    540

acaccactaa gaatctggtg gtgactgcag agatgtgctg ctactgcttc gacgtactct    600

actgtcacct ctatggcttc ccacagccac gacttcctag attcaccaat gacccctatc    660

cgctctttgt gacgtggaag acagggcggg acaagcggct tcgtggctgc attgggacct    720

tctcagccat gaatcttcat tcaggactca gggaatacac gttaaccagt gcacttaagg    780

acagccgatt tccccccctg acccgagagg agctgcctaa acttttctgc tctgtctccc    840

tccttactaa ctttgaggat gccagtgatt acctggactg ggaggtaggg gtccatggga    900

ttcgaattga attcattaat gaaaaaggtg tcaaacgcac agccacatat ttacctgagg    960

ttgctaagga acaagactgg gatcagatcc agacaataga ctccttgctc aggaaaggtg   1020

gctttaaagc tccaattacc agtgaattca gaaaaacgat caaactcacc aggtaccgaa   1080

gtgagaaggt gacaatcagt tacgcagagt atattgcttc ccgacagcac tgtttccaga   1140

acggcactct tcatgccccg cccctctaca atcattactc ctgacacacg gctgcatgac   1200

cagtcccacc cccccgtggc caccaatggc tatgacatca ttggagcaga tgcctcctct   1260

tcctggtcca gttacttcta ttactgcacc attttatgat gctagcttcc gttgccaagt   1320

ctgcctcccg ctgactgagg gagggtaggg ttaccttgaa cgaaacagaa cttgaggggc   1380

ccaagcctta tctcagcctt tcctcaatat ggggttccgt tggattgggg ctcctccatg   1440

actagtggga attactgtgg gttcagaaga cccttgtctg gtatttgcca catggggtat   1500

tggccacacg ctggaagctg aaattgatga tccctgaagg ttgaacccac acacacccct   1560

gcagcctccc cagatgaagt aggtgtattc ccctggcagt ctgggcaacg gagaccaaga   1620

aacattttta ggttgtttta aattcctttt tttaaacttc cagtttattg cgtaccaaga   1680

gttgattaca acctccatgc ttcataagcg gacgccacgt tagggttgga cgtgggcacc   1740

acgagtcctt tgaggctcct ggacagagac ccacatcaag atcggaagcc ctttgggtgg   1800

cgttgcagat ctcattgctc agtaggccgt gaagattttc atcctcatcc cactctcagt   1860

tggattttct ggcactcttc ctgcattgag tctcctgatt actgaacaga gctccgtcat   1920

gtagcctgct gaggaatgga atggaatgga gatgcccaca ggaggtcctg atgtcatcac   1980

tgcacgcagg tgtgagagga gagacctctt ctgcaccgcc tggctacctc actcctctgc   2040

tggtagcagt gcctatagct ggacctaagt tctcagaagc gtagatgtgc aaacaagcga   2100

ttgagttggg ctttaggagg acacatcata ggagagaatc cagggtctgt aagctggttt   2160

tcttttcagg tgacatcctg aggggcctgt aagcagggga gctccttttt ctagtttgcc   2220

tgtagaggtg ggaagactgt tggtgtttct gtcctttaca ggacattagg aaacagttgt   2280

gtaattacac aaggtggacc tttatcttgc ctgacatgct gggaatcttc accccaccag   2340

ggcaaatttc caaatagctc attttattct aggtctttca aactttcatg tgacatattt   2400

ccctttccca ttgttgctga tttccaaatc gctgtcagca attttttcct ctctccttgc   2460

ctattcttca ctcatttggt ggcaaagttc atagaactag gggacttgga agatgctttg   2520

aaaatattgt tacaaaggca ctgctaaaat gattcacagg gagagtggcc agttggaaga   2580

aggatcctaa ggatgtgaca ctggttttca acaacatgct tagagaactc atgaagtgga   2640

ttgggtgtca acccagtgaa catgttttta tttaatttat tttttgaagt ttatgtggtg   2700

atggtgtggc tttccgaaat gggcaaatat tcagaagatc ttttgcattt tcttctgtca   2760

ggaatgggga aggggagtgg gggcacaatc tgagaaagga cacctgtgct gttctaggca   2820

tcgctggcaa gtttgtggga agggatgggc aagggtgagt gggtttgctc cacaccgtcc   2880

tgtgctgctc gagaggacct gggacgtgcg agggaaacgt gggtgacggt gcctaggctg   2940

cggcccttca ctgctgtgct gggttcctgc agcctgctac gtttcccttg gcaatgtaaa   3000

tgaagatgga ggggtcgttt cgtgatttcc tgctgctgag aataaatgtc ttgttaaaaa   3060

cgtggcaacg gttactctta ggtgccatgg atcgatgtca gggtggtcag ctctggacta   3120

agccacccac ctccaatttg tacaacagta ttgatacata gggctacact cattactgtt   3180

caagtgttct atgttaagag ttgtgtttaa tttctaaaga ttaaaaaaag caaaaaaatt   3240

ggtgctaaac cttcacccct gagcacgctc agtgagactg gtcatgcaag catttacagt   3300

gccatgctcc tcaagccgat tttttcttgt agaaatgttg ccctatttgt cttctccaat   3360

gtatggtatg ttattttatt ttattatttt attttatttt attttatttt atcgaggggg   3420

ggtacgatac ctgccattta agaaaatgaa tagaaaattt taaaacccga gaaatgggga   3480

aaaaaaaatc agtgcacaag aattgggctg gttaggccca gcaccacact gaagtgggct   3540

cagtggtttt tggagtgaag aagccttact ccctgcacat tccctcatgc tcccacacaa   3600

gtccagcaat ggaaatgctt gggttcctct tgctttgtca ggggactcag gagtcgacca   3660

agggaaacca tttggccccg tgaggaatgg gcattgtcag tatccgtcct gaacggggcc   3720

tagtcaggaa gcggtctaga agtgtacggt cacggtcgcc tcatgaaagt gtgtagcagg   3780

tggctctcag gaaaaatacc aagtctggat catccatgtg gcagctttgc atagggagag   3840

gatagctccg aactggaact gaactgcctt ctctgcacgc ttgaccaaag cagtgatgag   3900

ggcggccagt acctgcggtg tgcgtggtag gtttaaagaa aagggaatgt tttctgctga   3960

gtgtttcctt tgtccttggg ctgctcgagc tggacagtag gtaaccactg ttttcaagga   4020

ccagcccaat ttctctggct tggttcggag ttcgtttcat ccctagctgt gagtgccttt   4080

tggtctggaa agttggcttg tctcataata cccacagcta ggacattctc tctgtaatta   4140

tgaattgtcc ttgttttaca ttaaaagaga atgtctttga tcactagagt ctgtcggtgt   4200

tggattattt ccactgtgag attcttaaaa cttttttgct tcataataat aaaacaactc   4260

atgttagaga ccctttcaac atgaaaggtt tgtagttgag acattacata tattttattg   4320

tttataataa aaatcatcta tacaaaagaa gtcctgggtg ttaatatttt gcacaagatc   4380

tgttttccat gatgtgttga catctacaat ttcactaact gttgacgtta ttttctattg   4440

agattctgga gcctagggag ctatgtgttc tttttgttca tttcgttctt acttccctga   4500

agcaagagac tatatggcct tcagtgcaaa gacttcagac caattctttg tattacactt   4560

ggttgcctct tggctatata acttctgagt gcaaatcatt gaacacttta acgaagtatt   4620

gtagagaata aatcataatg gataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   4680

aaaaaaaaaa aaaaaaaa                                                 4698


<210>  620
<211>  310
<212>  PRT
<213>  Homosapiens

<400>  620

Met Gly Lys Arg Arg Cys Val Pro Pro Leu Glu Pro Lys Leu Ala Ala 
1               5                   10                  15      


Gly Cys Cys Gly Val Lys Lys Pro Lys Leu Ser Gly Ser Gly Thr His 
            20                  25                  30          


Ser His Gly Asn Gln Ser Thr Thr Val Pro Gly Ser Ser Ser Gly Pro 
        35                  40                  45              


Leu Gln Asn His Gln His Val Asp Ser Ser Ser Gly Arg Glu Asn Val 
    50                  55                  60                  


Ser Asp Leu Thr Leu Gly Pro Gly Asn Ser Pro Ile Thr Arg Met Asn 
65                  70                  75                  80  


Pro Ala Ser Gly Ala Leu Ser Pro Leu Pro Arg Pro Asn Gly Thr Ala 
                85                  90                  95      


Asn Thr Thr Lys Asn Leu Val Val Thr Ala Glu Met Cys Cys Tyr Cys 
            100                 105                 110         


Phe Asp Val Leu Tyr Cys His Leu Tyr Gly Phe Pro Gln Pro Arg Leu 
        115                 120                 125             


Pro Arg Phe Thr Asn Asp Pro Tyr Pro Leu Phe Val Thr Trp Lys Thr 
    130                 135                 140                 


Gly Arg Asp Lys Arg Leu Arg Gly Cys Ile Gly Thr Phe Ser Ala Met 
145                 150                 155                 160 


Asn Leu His Ser Gly Leu Arg Glu Tyr Thr Leu Thr Ser Ala Leu Lys 
                165                 170                 175     


Asp Ser Arg Phe Pro Pro Leu Thr Arg Glu Glu Leu Pro Lys Leu Phe 
            180                 185                 190         


Cys Ser Val Ser Leu Leu Thr Asn Phe Glu Asp Ala Ser Asp Tyr Leu 
        195                 200                 205             


Asp Trp Glu Val Gly Val His Gly Ile Arg Ile Glu Phe Ile Asn Glu 
    210                 215                 220                 


Lys Gly Val Lys Arg Thr Ala Thr Tyr Leu Pro Glu Val Ala Lys Glu 
225                 230                 235                 240 


Gln Asp Trp Asp Gln Ile Gln Thr Ile Asp Ser Leu Leu Arg Lys Gly 
                245                 250                 255     


Gly Phe Lys Ala Pro Ile Thr Ser Glu Phe Arg Lys Thr Ile Lys Leu 
            260                 265                 270         


Thr Arg Tyr Arg Ser Glu Lys Val Thr Ile Ser Tyr Ala Glu Tyr Ile 
        275                 280                 285             


Ala Ser Arg Gln His Cys Phe Gln Asn Gly Thr Leu His Ala Pro Pro 
    290                 295                 300                 


Leu Tyr Asn His Tyr Ser 
305                 310 


<210>  621
<211>  4082
<212>  DNA
<213>  Homosapiens

<400>  621
gaggactgcg agcacagcgg cggccgggtg gcgggggtga gtggggccag cggggctgga     60

cagcagcggg ccccgggcgc cgccgccgcg atccctcccc gcgcccgccg agcacatcgc    120

cgccgccgag atgggccctc cgcggcaccc ccaggccggc gagatagaag cgggcggtgc    180

gggcggcggg cggcggctac aggtggaaat gagttctcaa cagtttcctc ggttaggagc    240

cccttctacc gggctgagcc aggccccttc tcagattgca aacagtggtt ctgctggatt    300

gataaaccca gctgctacag tcaatgatga atctggtcga gattctgaag tcagtgccag    360

ggagcacatg agttccagca gctccctcca gtcccgggag gagaagcaag agcctgttgt    420

ggtaaggccc tatccacagg tgcagatgtt gtcgacacac catgctgtcg catcagccac    480

acctgttgca gtgacagccc cgccagcaca cctgacgcca gcagtgccac tttcattttc    540

ggagggactt atgaagccgc ccccgaagcc caccatgcct agccgtccca ttgctcctgc    600

tccaccttct accctgtcac ttccccccaa ggttccaggg caggttaccg ttaccatgga    660

gagtagcatc cctcaagctt cagccattcc tgtggcaaca atcagtggac aacagggcca    720

tcccagtaac ctgcatcaca tcatgactac aaatgtgcaa atgtctatca tccgcagcaa    780

tgctcctggg ccccctcttc acattggagc ttctcattta cctcgaggtg cagctgctgc    840

tgctgtgatg tccagttcta aagtaaccac agtcctgagg ccgacctcac agctgccaaa    900

tgctgctact gctcagccag cagtacagca catcattcac caaccaatcc agtctcggcc    960

acctgtgacc acctccaatg ccatccctcc tgctgtggta gcaactgtct cagccaccag   1020

agctcagtct ccagtcatca ctacgacagc ggcgcatgct actgattcag cacttagtag   1080

gccaaccttg tctatccagc atcctccatc tgcagcaatc agtattcagc gtcctgccca   1140

gtcacgagat gtcacaacaa gaatcacact accatctcac cctgcattag ggacgccaaa   1200

acagcagctt catacaatgg ctcagaaaac aatcttcagt actggcacgc cagtggctgc   1260

agccacagta gcacctattt tggcaaccaa caccattcct tcagcgacca cagctggatc   1320

tgtgtcacac acgcaagctc ccacaagtac cattgttacc atgacagtac cctcccattc   1380

ctcccatgct actgctgtga ccacctcaaa catcccagtc gccaaggtgg tgccccagca   1440

gatcacgcac acttctcctc ggatccagcc agactaccct gccgagagga gtagcctgat   1500

tcccatctcc ggacatcggg cctctcccaa tcctgtggcc atggaaaccc gaagtgacaa   1560

cagaccgtct gttcccgttc agttccaata ttttttgcca acttaccccc cttctgcata   1620

cccactggcg gcacatacct acaccccaat caccagttcc gtgtccacta tccgacagta   1680

tccagtttca gctcaggctc caaactctgc catcacagct cagactggtg ttggggtagc   1740

gtctaccgtc cacctaaacc ccatgcagtt gatgacagtg gatgcatcgc atgctcgaca   1800

tattcaaggg atccagccag cacccatcag tacccagggt atccagccgg cccccattgg   1860

gaccccaggg atacagcctg caccacttgg cacacaggga attcactcag caaccccaat   1920

caacacacaa gggcttcagc ctgcacctat gggtactcag cagcctcagc ctgaaggaaa   1980

gacttcagca gtggtgttgg cagatggagc cacaattgtg gccaacccta ttagcaatcc   2040

attcagtgct gctccagcag caacaaccgt ggtgcagacc cacagccaga gtgctagcac   2100

caacgctccc gcccagggct catcgccacg gccaagcata ctccggaaga aacctgccac   2160

agatggtgcc aaacccaagt ctgaaatcca cgtgtctatg gccactccgg tcactgtgtc   2220

catggagact gtatccaatc aaaataatga tcagcctacc attgccgtcc ctccaactgc   2280

ccagcagccc ccaccgacca ttccaactat gattgcagca gccagtcccc cgtcacaacc   2340

agccgttgcc ctttcaacca ttcctggagc ggtccccatc actccaccca tcaccaccat   2400

tgcagctgca ccacctccat cagtcactgt gggtggcagt ctttcctccg tcttgggccc   2460

tcccgttcct gaaattaaag tgaaagaaga agtagaacca atggatatca tgaggccagt   2520

ttctgcagtt cctccactgg ctaccaacac tgtgtctcca tctcttgcat tgctggcaaa   2580

caacttgtcc atgcctacaa gtgacctacc acctggtgcc tccccaagga aaaagcctcg   2640

aaagcaacag catgtgatct caacagaaga aggtgacatg atggagacaa acagcactga   2700

tgatgagaag tccactgcca agagtcttct ggtgaaggct gagaagcgca agtctcctcc   2760

caaggagtat attgatgagg aaggtgtgag atatgtccca gtgcgtccaa gaccccccat   2820

tactttgctt cgtcactatc ggaacccctg gaaagctgct taccaccact ttcagaggta   2880

cagtgacgtc cgggtcaaag aggagaagaa agctatgctg caggaaatag ctaatcagaa   2940

aggagtatcc tgtcgtgctc aaggctggaa agtccacctc tgtgctgccc agttactaca   3000

gctgacgaat ctagaacatg atgtctatga aagacttact aacctgcagg aagggattat   3060

cccaaagaaa aaagcagcaa cagatgatga tctccaccga ataaacgaac tgatacaggg   3120

aaatatgcag aggtgtaaac ttgtgatgga tcaaatcagt gaagccagag actccatgct   3180

taaggtttta gatcataaag accgtgtcct gaagctgctt aacaagaacg ggactgtcaa   3240

aaaagtgtcc aaattgaagc gaaaggaaaa agtctagacc cagaacaatc aggagattgg   3300

aagcaaattt atgaagaatg atggtggggg tggggggagg gttttggttt tttccaaagt   3360

ggaacattga aataaaggaa gtgttcctta gttcccgtgt gaaagcagag gaacccatga   3420

catccaaggg cgtgaaagga tcagagctga ctggacatag tgagctgcct tcttgcgttc   3480

gggtgcaccc ctgttaaacc tgatctgtgt cataagtgac tccggatgca tcagtgtcca   3540

ccagttggaa gcaatgacaa ggatggctgg ctggtgtttt tcagccttcc ggtttataga   3600

ctgtatttat ctagtggatt cctgcaggcc ccatactgag cctggactga aagtatccac   3660

tcggaccatc tgttatctct ctacactgaa aataaaacct cttccaccca ccccattcgg   3720

ttcttctgcc tgaccttcaa atgcccatgt tggcctttta cagcagtgcc acggcaccaa   3780

gcgagctgcc acatctcaca ctctaaaggg tttgaactat tagttcttgt cattttttaa   3840

aaaaaaccat tcccaagtga aattgttata tcgtctgtct tgcgtgtgtc agaactgggt   3900

ttttgtggag gttcagagca ggcaacacca taagttgctc tcagatcctt gttctgaagt   3960

acattcttgg ttatctgtac ttctgtagct ggtgtgatgc tgttaattgt atgtaccaca   4020

catctccaga cgttaataaa ggactcaaag aggtttttgt aaaaaaaaaa aaaaaaaaaa   4080

aa                                                                  4082


<210>  622
<211>  1048
<212>  PRT
<213>  Homosapiens

<400>  622

Met Gly Pro Pro Arg His Pro Gln Ala Gly Glu Ile Glu Ala Gly Gly 
1               5                   10                  15      


Ala Gly Gly Gly Arg Arg Leu Gln Val Glu Met Ser Ser Gln Gln Phe 
            20                  25                  30          


Pro Arg Leu Gly Ala Pro Ser Thr Gly Leu Ser Gln Ala Pro Ser Gln 
        35                  40                  45              


Ile Ala Asn Ser Gly Ser Ala Gly Leu Ile Asn Pro Ala Ala Thr Val 
    50                  55                  60                  


Asn Asp Glu Ser Gly Arg Asp Ser Glu Val Ser Ala Arg Glu His Met 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Leu Gln Ser Arg Glu Glu Lys Gln Glu Pro Val 
                85                  90                  95      


Val Val Arg Pro Tyr Pro Gln Val Gln Met Leu Ser Thr His His Ala 
            100                 105                 110         


Val Ala Ser Ala Thr Pro Val Ala Val Thr Ala Pro Pro Ala His Leu 
        115                 120                 125             


Thr Pro Ala Val Pro Leu Ser Phe Ser Glu Gly Leu Met Lys Pro Pro 
    130                 135                 140                 


Pro Lys Pro Thr Met Pro Ser Arg Pro Ile Ala Pro Ala Pro Pro Ser 
145                 150                 155                 160 


Thr Leu Ser Leu Pro Pro Lys Val Pro Gly Gln Val Thr Val Thr Met 
                165                 170                 175     


Glu Ser Ser Ile Pro Gln Ala Ser Ala Ile Pro Val Ala Thr Ile Ser 
            180                 185                 190         


Gly Gln Gln Gly His Pro Ser Asn Leu His His Ile Met Thr Thr Asn 
        195                 200                 205             


Val Gln Met Ser Ile Ile Arg Ser Asn Ala Pro Gly Pro Pro Leu His 
    210                 215                 220                 


Ile Gly Ala Ser His Leu Pro Arg Gly Ala Ala Ala Ala Ala Val Met 
225                 230                 235                 240 


Ser Ser Ser Lys Val Thr Thr Val Leu Arg Pro Thr Ser Gln Leu Pro 
                245                 250                 255     


Asn Ala Ala Thr Ala Gln Pro Ala Val Gln His Ile Ile His Gln Pro 
            260                 265                 270         


Ile Gln Ser Arg Pro Pro Val Thr Thr Ser Asn Ala Ile Pro Pro Ala 
        275                 280                 285             


Val Val Ala Thr Val Ser Ala Thr Arg Ala Gln Ser Pro Val Ile Thr 
    290                 295                 300                 


Thr Thr Ala Ala His Ala Thr Asp Ser Ala Leu Ser Arg Pro Thr Leu 
305                 310                 315                 320 


Ser Ile Gln His Pro Pro Ser Ala Ala Ile Ser Ile Gln Arg Pro Ala 
                325                 330                 335     


Gln Ser Arg Asp Val Thr Thr Arg Ile Thr Leu Pro Ser His Pro Ala 
            340                 345                 350         


Leu Gly Thr Pro Lys Gln Gln Leu His Thr Met Ala Gln Lys Thr Ile 
        355                 360                 365             


Phe Ser Thr Gly Thr Pro Val Ala Ala Ala Thr Val Ala Pro Ile Leu 
    370                 375                 380                 


Ala Thr Asn Thr Ile Pro Ser Ala Thr Thr Ala Gly Ser Val Ser His 
385                 390                 395                 400 


Thr Gln Ala Pro Thr Ser Thr Ile Val Thr Met Thr Val Pro Ser His 
                405                 410                 415     


Ser Ser His Ala Thr Ala Val Thr Thr Ser Asn Ile Pro Val Ala Lys 
            420                 425                 430         


Val Val Pro Gln Gln Ile Thr His Thr Ser Pro Arg Ile Gln Pro Asp 
        435                 440                 445             


Tyr Pro Ala Glu Arg Ser Ser Leu Ile Pro Ile Ser Gly His Arg Ala 
    450                 455                 460                 


Ser Pro Asn Pro Val Ala Met Glu Thr Arg Ser Asp Asn Arg Pro Ser 
465                 470                 475                 480 


Val Pro Val Gln Phe Gln Tyr Phe Leu Pro Thr Tyr Pro Pro Ser Ala 
                485                 490                 495     


Tyr Pro Leu Ala Ala His Thr Tyr Thr Pro Ile Thr Ser Ser Val Ser 
            500                 505                 510         


Thr Ile Arg Gln Tyr Pro Val Ser Ala Gln Ala Pro Asn Ser Ala Ile 
        515                 520                 525             


Thr Ala Gln Thr Gly Val Gly Val Ala Ser Thr Val His Leu Asn Pro 
    530                 535                 540                 


Met Gln Leu Met Thr Val Asp Ala Ser His Ala Arg His Ile Gln Gly 
545                 550                 555                 560 


Ile Gln Pro Ala Pro Ile Ser Thr Gln Gly Ile Gln Pro Ala Pro Ile 
                565                 570                 575     


Gly Thr Pro Gly Ile Gln Pro Ala Pro Leu Gly Thr Gln Gly Ile His 
            580                 585                 590         


Ser Ala Thr Pro Ile Asn Thr Gln Gly Leu Gln Pro Ala Pro Met Gly 
        595                 600                 605             


Thr Gln Gln Pro Gln Pro Glu Gly Lys Thr Ser Ala Val Val Leu Ala 
    610                 615                 620                 


Asp Gly Ala Thr Ile Val Ala Asn Pro Ile Ser Asn Pro Phe Ser Ala 
625                 630                 635                 640 


Ala Pro Ala Ala Thr Thr Val Val Gln Thr His Ser Gln Ser Ala Ser 
                645                 650                 655     


Thr Asn Ala Pro Ala Gln Gly Ser Ser Pro Arg Pro Ser Ile Leu Arg 
            660                 665                 670         


Lys Lys Pro Ala Thr Asp Gly Ala Lys Pro Lys Ser Glu Ile His Val 
        675                 680                 685             


Ser Met Ala Thr Pro Val Thr Val Ser Met Glu Thr Val Ser Asn Gln 
    690                 695                 700                 


Asn Asn Asp Gln Pro Thr Ile Ala Val Pro Pro Thr Ala Gln Gln Pro 
705                 710                 715                 720 


Pro Pro Thr Ile Pro Thr Met Ile Ala Ala Ala Ser Pro Pro Ser Gln 
                725                 730                 735     


Pro Ala Val Ala Leu Ser Thr Ile Pro Gly Ala Val Pro Ile Thr Pro 
            740                 745                 750         


Pro Ile Thr Thr Ile Ala Ala Ala Pro Pro Pro Ser Val Thr Val Gly 
        755                 760                 765             


Gly Ser Leu Ser Ser Val Leu Gly Pro Pro Val Pro Glu Ile Lys Val 
    770                 775                 780                 


Lys Glu Glu Val Glu Pro Met Asp Ile Met Arg Pro Val Ser Ala Val 
785                 790                 795                 800 


Pro Pro Leu Ala Thr Asn Thr Val Ser Pro Ser Leu Ala Leu Leu Ala 
                805                 810                 815     


Asn Asn Leu Ser Met Pro Thr Ser Asp Leu Pro Pro Gly Ala Ser Pro 
            820                 825                 830         


Arg Lys Lys Pro Arg Lys Gln Gln His Val Ile Ser Thr Glu Glu Gly 
        835                 840                 845             


Asp Met Met Glu Thr Asn Ser Thr Asp Asp Glu Lys Ser Thr Ala Lys 
    850                 855                 860                 


Ser Leu Leu Val Lys Ala Glu Lys Arg Lys Ser Pro Pro Lys Glu Tyr 
865                 870                 875                 880 


Ile Asp Glu Glu Gly Val Arg Tyr Val Pro Val Arg Pro Arg Pro Pro 
                885                 890                 895     


Ile Thr Leu Leu Arg His Tyr Arg Asn Pro Trp Lys Ala Ala Tyr His 
            900                 905                 910         


His Phe Gln Arg Tyr Ser Asp Val Arg Val Lys Glu Glu Lys Lys Ala 
        915                 920                 925             


Met Leu Gln Glu Ile Ala Asn Gln Lys Gly Val Ser Cys Arg Ala Gln 
    930                 935                 940                 


Gly Trp Lys Val His Leu Cys Ala Ala Gln Leu Leu Gln Leu Thr Asn 
945                 950                 955                 960 


Leu Glu His Asp Val Tyr Glu Arg Leu Thr Asn Leu Gln Glu Gly Ile 
                965                 970                 975     


Ile Pro Lys Lys Lys Ala Ala Thr Asp Asp Asp Leu His Arg Ile Asn 
            980                 985                 990         


Glu Leu Ile Gln Gly Asn Met Gln  Arg Cys Lys Leu Val  Met Asp Gln 
        995                 1000                 1005             


Ile Ser  Glu Ala Arg Asp Ser  Met Leu Lys Val Leu  Asp His Lys 
    1010                 1015                 1020             


Asp Arg  Val Leu Lys Leu Leu  Asn Lys Asn Gly Thr  Val Lys Lys 
    1025                 1030                 1035             


Val Ser  Lys Leu Lys Arg Lys  Glu Lys Val 
    1040                 1045             


<210>  623
<211>  5078
<212>  DNA
<213>  Homosapiens

<400>  623
taatactcct ttattccctg ttttaaaaat ttttttaaat ttgatacaat aattatacat     60

aataatggag taccatgtga gattcaatcc acatatacat tgtgaaatga tcaaattagg    120

atagttagca tgcacatcac ccccaaataa ttattacttt tgtggtgaga acacttaaaa    180

ttgtctcttt tagaaatata cgttattatt aaccatagtc acctcgctgt gcaatagaac    240

accagaactt attcctccta aatgtaactt tttacccatt gaccactccc tcctcacccc    300

cctctctcct ccccacccct ggtaaccact gttctgttat ctcctatgat agcaactttt    360

tagcttctgc atgtgagatt gtacggtagt tgcctttctg tgcctggatt atttcattta    420

gcataatgtc cttcgggtat atccctgttg ctgcaaaaga caggatttct ctctcttttt    480

ctggttgaat agtattccat tgtcagagaa tgttgtaaga ctaggaaagg aacactgcag    540

gctggagccc tggggaaatg gtctgaggca ggtggtggga ctagagctgg ggtctggcaa    600

acaggctggg tttgattgtc agcataatag agagcactca tgtgccagct gggtgggagg    660

agcagccgag tgaagaaggg gaagcctctc aggaagcatg tgcagggttt atggtaatga    720

gcagaccagc aggtacgtag tgggagaggg gtgtgatggg gcagaggaac ttacgttatg    780

atagtacaag acagaggttg agcctcattt taataggcat tgtggtgggt gttgaatagt    840

gatggaatgt atgggtctgg aatcaggctg cctggtcaag ggctctgaaa catgagtgtg    900

catcagaatc acctcgaggc ttgttaaagg ataggctgtg gaccacatct cctcagttgc    960

tgattcagtg ggtgtgggtg gggcctgaga attcacattt cccactggtg atgctgctgt   1020

tactgattgg gaccacattt ggggaacact ggtctagaat tgagaggttg gcaaaccttc   1080

tctgttaaga ggtagatagt aaatatttta ggccttctgg gctacaaaga gtatctgtta   1140

catatttttt attgcttttc atgacccatt aagcatatat atatcattct ctgccatata   1200

caaacaggct gttgggggag tgaggatgat gtagggaagg tggggcatgg tttaataacc   1260

cctgggccat gcctagatga tcagtcctct gccacatagc tggctgacct ttgccaagtt   1320

aatcaccttt tacctttatt ttctcatgtt tctaataaaa cagagacgat aatattcata   1380

cttcttacca tatagaactt ctgaggattc agtgagcaaa gccacaaaag atggtatgtc   1440

acaatatctg ggatatagct agaatttata atttattttt actctgttga taggcaatgg   1500

gaaaacagta agaggcagac caacagtgat ccagggctct gaaagctaat tgcttcaaga   1560

tcctgctacc attttctttt gggccgcttg caaagaagaa tcctttgact gaagcatgta   1620

tgtacactct gaagtacagc ctgggttagt ctcttataag ggatcggatc attgctcagc   1680

tctcccttga gtggcactta gaaaatggcg ctattcgtaa gctgactggt attgggccca   1740

ggactctggc tgaaggggtg ggcatgctgg taaccatttg caacctatgc tcaggtccta   1800

cttgttggga agccctgatt gagaagagtg gcctggtctg tgctggcatt agataggatc   1860

tggctgcatt aatattgaaa ctactctgcc ttttaatgtc tcattttgcc tcatggtggg   1920

agtgaaagtg agaaccacag aaaatctgcc tgccaggtgt tccacatttc ttgtgctaca   1980

gcatgcaagt gagcagtgag gtgtaccttt tcctcatgta gctgggaaag caatacccct   2040

gcttgtacct ctggcatatc ttctctgtgc tggtgcacct agagaggttg cctggtggcc   2100

ctgagagagc catctcatca ctaaacactg atggtgaaaa gctggccatg ctcaaataag   2160

atgtagcaat ctacctcttc tttgtctagt tacccccaag ggggcatcca ctttcttgct   2220

cacctcacca gttgcatgtt ctagtccttg ccagaagcac ataataatga ctttgtaagc   2280

ttaagttaca ggcacacaaa agggcctgat ggtgatatga ctccaccctc cccgtttttg   2340

ctgacattcc gccaaatatc cttctgtctc ctccccacct tgcaaaacaa acttcctgtt   2400

ttgaatttgg tccaggctgg aacagcccca ccacacctgt taacacacgc agacgcacac   2460

ttcccccttc ataattgctt agcttcttgt tgcctagcca gatttcccct cagcttacag   2520

ttcctgaatc ataagatatt gaaccagcaa atttaagagt tgacatttta cttagaggta   2580

ttcaagtgaa aacatggctt ctggtttatt ttgctgtatt gtgccatgac cacttggcta   2640

attcttctcc tccttcacat cagaatggaa gtgaggaaag gcaaccagct gacacaggag   2700

ccagagtgag accagcagac tctcacactc aacctacacc atgaatttgt gtctatcttc   2760

tacgcgttaa gagccaagga caggtgaagt tgccagagag caatggctct cttcactccg   2820

tggaagttgt cctctcagaa gctgggcttt ttcctggtga cttttggctt catttggggt   2880

atgatgcttc tgcactttac catccagcag cgaactcagc ctgaaagcag ctccatgctg   2940

cgcgagcaga tcctggacct cagcaaaagg tacatcaagg cactggcaga agaaaacagg   3000

aatgtggtgg atgggccata cgctggagtc atgacagctt atgatctgaa gaaaaccctt   3060

gctgtgttat tagataacat tttgcagcgc attggcaagt tggagtcgaa ggtggacaat   3120

cttgttgtca atggcaccgg aacaaactca accaactcca ctacagctgt tcccagcttg   3180

gttgcacttg agaaaattaa tgtggcagat atcattaacg gagctcaaga aaaatgtgta   3240

ttgcctccta tggacggcta ccctcactgt gagggaaaga tcaagtggat gaaagacatg   3300

tggcgttcag atccctgcta cgcagactat ggagtggatg gatccacctg ctcttttttt   3360

atttacctca gtgaggttga aaattggtgt cctcatttac cttggagagc aaaaaatccc   3420

tacgaagaag ctgatcataa ttcattggcg gaaattcgta cagattttaa tattctctac   3480

agtatgatga aaaagcatga agaattccgg tggatgagac tacggatccg gcgaatggct   3540

gacgcatgga tccaagcaat caagtccctg gcagaaaagc agaaccttga aaagagaaag   3600

cggaagaaag tcctcgttca cctgggactc ctgaccaagg aatctggatt taagattgca   3660

gagacagctt tcagtggtgg ccctcttggt gaattagttc aatggagtga tttaattaca   3720

tctctgtact tactgggcca tgacattagg atttcagctt cactggctga gctcaaggaa   3780

atcatgaaga aggttgtagg aaaccgatct ggctgcccaa ctgtaggaga cagaattgtt   3840

gagctcattt acattgatat tgtaggactt gctcaattca agaaaactct tggaccatcc   3900

tgggttcatt accagtgcat gctccgagtc cttgattcat ttggtactga acccgaattt   3960

aatcatgcaa attatgccca atcgaaaggc cacaagaccc cttggggaaa atggaatctg   4020

aaccctcagc agttttatac catgttccct cataccccag acaacagctt tctggggttt   4080

gtggttgagc agcacctgaa ctccagtgat atccaccaca ttaatgaaat caaaaggcag   4140

aaccagtccc ttgtgtatgg caaagtggat agcttctgga agaataagaa gatctacttg   4200

gacattattc acacatacat ggaagtgcat gcaactgttt atggctccag cacaaagaat   4260

attcccagtt acgtgaaaaa ccatggtatc ctcagtggac gggacctgca gttccttctt   4320

cgagaaacca agttgtttgt tggacttggg ttcccttacg agggcccagc tcccctggaa   4380

gctatcgcaa atggatgtgc ttttctgaat cccaagttca acccacccaa aagcagcaaa   4440

aacacagact ttttcattgg caagccaact ctgagagagc tgacatccca gcatccttac   4500

gctgaagttt tcatcgggcg gccacatgtg tggactgttg acctcaacaa tcaggaggaa   4560

gtagaggatg cagtgaaagc aattttaaat cagaagattg agccatacat gccatatgaa   4620

tttacgtgcg aggggatgct acagagaatc aatgctttca ttgaaaaaca ggacttctgc   4680

catgggcaag tgatgtggcc acccctcagc gccctacagg tcaagcttgc tgagcccggg   4740

cagtcctgca agcaggtgtg ccaggagagc cagctcatct gcgagccttc tttcttccag   4800

cacctcaaca aggacaagga catgctgaag tacaaggtga cctgccaaag ctcagagctg   4860

gccaaggaca tcctggtgcc ctcctttgac cctaagaata agcactgtgt gtttcaaggt   4920

gacctcctgc tcttcagctg tgcaggcgcc caccccaggc accagagggt ctgcccctgc   4980

cgggacttca tcaagggcca ggtggctctc tgcaaagact gcctatagca gctacctgct   5040

cagccctgca ccatgctgct ggggaagaca gtggcccc                           5078


<210>  624
<211>  741
<212>  PRT
<213>  Homosapiens

<400>  624

Met Ala Leu Phe Thr Pro Trp Lys Leu Ser Ser Gln Lys Leu Gly Phe 
1               5                   10                  15      


Phe Leu Val Thr Phe Gly Phe Ile Trp Gly Met Met Leu Leu His Phe 
            20                  25                  30          


Thr Ile Gln Gln Arg Thr Gln Pro Glu Ser Ser Ser Met Leu Arg Glu 
        35                  40                  45              


Gln Ile Leu Asp Leu Ser Lys Arg Tyr Ile Lys Ala Leu Ala Glu Glu 
    50                  55                  60                  


Asn Arg Asn Val Val Asp Gly Pro Tyr Ala Gly Val Met Thr Ala Tyr 
65                  70                  75                  80  


Asp Leu Lys Lys Thr Leu Ala Val Leu Leu Asp Asn Ile Leu Gln Arg 
                85                  90                  95      


Ile Gly Lys Leu Glu Ser Lys Val Asp Asn Leu Val Val Asn Gly Thr 
            100                 105                 110         


Gly Thr Asn Ser Thr Asn Ser Thr Thr Ala Val Pro Ser Leu Val Ala 
        115                 120                 125             


Leu Glu Lys Ile Asn Val Ala Asp Ile Ile Asn Gly Ala Gln Glu Lys 
    130                 135                 140                 


Cys Val Leu Pro Pro Met Asp Gly Tyr Pro His Cys Glu Gly Lys Ile 
145                 150                 155                 160 


Lys Trp Met Lys Asp Met Trp Arg Ser Asp Pro Cys Tyr Ala Asp Tyr 
                165                 170                 175     


Gly Val Asp Gly Ser Thr Cys Ser Phe Phe Ile Tyr Leu Ser Glu Val 
            180                 185                 190         


Glu Asn Trp Cys Pro His Leu Pro Trp Arg Ala Lys Asn Pro Tyr Glu 
        195                 200                 205             


Glu Ala Asp His Asn Ser Leu Ala Glu Ile Arg Thr Asp Phe Asn Ile 
    210                 215                 220                 


Leu Tyr Ser Met Met Lys Lys His Glu Glu Phe Arg Trp Met Arg Leu 
225                 230                 235                 240 


Arg Ile Arg Arg Met Ala Asp Ala Trp Ile Gln Ala Ile Lys Ser Leu 
                245                 250                 255     


Ala Glu Lys Gln Asn Leu Glu Lys Arg Lys Arg Lys Lys Val Leu Val 
            260                 265                 270         


His Leu Gly Leu Leu Thr Lys Glu Ser Gly Phe Lys Ile Ala Glu Thr 
        275                 280                 285             


Ala Phe Ser Gly Gly Pro Leu Gly Glu Leu Val Gln Trp Ser Asp Leu 
    290                 295                 300                 


Ile Thr Ser Leu Tyr Leu Leu Gly His Asp Ile Arg Ile Ser Ala Ser 
305                 310                 315                 320 


Leu Ala Glu Leu Lys Glu Ile Met Lys Lys Val Val Gly Asn Arg Ser 
                325                 330                 335     


Gly Cys Pro Thr Val Gly Asp Arg Ile Val Glu Leu Ile Tyr Ile Asp 
            340                 345                 350         


Ile Val Gly Leu Ala Gln Phe Lys Lys Thr Leu Gly Pro Ser Trp Val 
        355                 360                 365             


His Tyr Gln Cys Met Leu Arg Val Leu Asp Ser Phe Gly Thr Glu Pro 
    370                 375                 380                 


Glu Phe Asn His Ala Asn Tyr Ala Gln Ser Lys Gly His Lys Thr Pro 
385                 390                 395                 400 


Trp Gly Lys Trp Asn Leu Asn Pro Gln Gln Phe Tyr Thr Met Phe Pro 
                405                 410                 415     


His Thr Pro Asp Asn Ser Phe Leu Gly Phe Val Val Glu Gln His Leu 
            420                 425                 430         


Asn Ser Ser Asp Ile His His Ile Asn Glu Ile Lys Arg Gln Asn Gln 
        435                 440                 445             


Ser Leu Val Tyr Gly Lys Val Asp Ser Phe Trp Lys Asn Lys Lys Ile 
    450                 455                 460                 


Tyr Leu Asp Ile Ile His Thr Tyr Met Glu Val His Ala Thr Val Tyr 
465                 470                 475                 480 


Gly Ser Ser Thr Lys Asn Ile Pro Ser Tyr Val Lys Asn His Gly Ile 
                485                 490                 495     


Leu Ser Gly Arg Asp Leu Gln Phe Leu Leu Arg Glu Thr Lys Leu Phe 
            500                 505                 510         


Val Gly Leu Gly Phe Pro Tyr Glu Gly Pro Ala Pro Leu Glu Ala Ile 
        515                 520                 525             


Ala Asn Gly Cys Ala Phe Leu Asn Pro Lys Phe Asn Pro Pro Lys Ser 
    530                 535                 540                 


Ser Lys Asn Thr Asp Phe Phe Ile Gly Lys Pro Thr Leu Arg Glu Leu 
545                 550                 555                 560 


Thr Ser Gln His Pro Tyr Ala Glu Val Phe Ile Gly Arg Pro His Val 
                565                 570                 575     


Trp Thr Val Asp Leu Asn Asn Gln Glu Glu Val Glu Asp Ala Val Lys 
            580                 585                 590         


Ala Ile Leu Asn Gln Lys Ile Glu Pro Tyr Met Pro Tyr Glu Phe Thr 
        595                 600                 605             


Cys Glu Gly Met Leu Gln Arg Ile Asn Ala Phe Ile Glu Lys Gln Asp 
    610                 615                 620                 


Phe Cys His Gly Gln Val Met Trp Pro Pro Leu Ser Ala Leu Gln Val 
625                 630                 635                 640 


Lys Leu Ala Glu Pro Gly Gln Ser Cys Lys Gln Val Cys Gln Glu Ser 
                645                 650                 655     


Gln Leu Ile Cys Glu Pro Ser Phe Phe Gln His Leu Asn Lys Asp Lys 
            660                 665                 670         


Asp Met Leu Lys Tyr Lys Val Thr Cys Gln Ser Ser Glu Leu Ala Lys 
        675                 680                 685             


Asp Ile Leu Val Pro Ser Phe Asp Pro Lys Asn Lys His Cys Val Phe 
    690                 695                 700                 


Gln Gly Asp Leu Leu Leu Phe Ser Cys Ala Gly Ala His Pro Arg His 
705                 710                 715                 720 


Gln Arg Val Cys Pro Cys Arg Asp Phe Ile Lys Gly Gln Val Ala Leu 
                725                 730                 735     


Cys Lys Asp Cys Leu 
            740     


<210>  625
<211>  1679
<212>  DNA
<213>  Homosapiens

<400>  625
ggcatttctg actcgagtcc ccgccgcgct tgtcgtcgcc gcagccggga tccgcagccc     60

cgcgccatgg agccggccgc gggcatccag cgccgcagct cccaggggcc caccgtcccg    120

ccgccgcccc ggggccacgc gccaccggct gccgcccccg gcccggcccc gctgagctcc    180

ccggtgcgcg agccgcccca gctggaggag gagcggcagg tgcggatcag cgagagcggc    240

cagttcagcg acgggctgga ggaccgaggc ttactagaaa gcagcacccg cctgaaacct    300

cacgaagccc agaactacag gaagaaggca ttgtgggtgt cctggttctc catcattgtc    360

accctggccc tcgcggtggc tgcctttact gtctccgtta tgaggtacag cgcctctgct    420

tttgggtttg catttgatgc catcctggac gtcctgtcat cggcgattgt cctgtggcgt    480

tacagcaacg cggccgctgt gcactctgcc catagggagt acatagcctg tgtcatcttg    540

ggggtgatat tccttctgtc atccatatgt atagtggtca aagccatcca tgacctctca    600

actaggctgc tcccagaagt ggacgatttc ctgttcagtg tctccatttt aagtgggatt    660

ctttgcagca tcctggccgt gttgaagttc atgctgggga aggttctgac cagtagagca    720

ctcataacag atgggtttaa ctccctcgtg ggtggcgtga tgggcttctc cattcttctg    780

agcgcggaag tgttcaagca tgactcagcg gtctggtacc tggacggcag cataggcgtt    840

ctgatcggcc tcaccatatt tgcctatggg gtcaaactcc tcatcgacat ggtgccgagg    900

gtgaggcaga cacgtcacta cgagatgttt gagtgaaggg ggccagcatc cgcatgagac    960

cattgagatg aggagtttcc acataggcaa agggtgccaa tatttaactg aacatctggt   1020

ttctttttgg aagttttctt tcacatggtt tgtcattaca agacaaggtc tgcccagcca   1080

ggtggatcta ccttgccccc atcacctgcc gcccccatca aacatgttgg gacaatgccc   1140

ataggaatgg acctccttcc ccgtctccag ctgggactgg tgttttttta gtctctggag   1200

tatgatggtt ctcatgggta ggatgagatc tttggcagaa aggtcttcgg tggtgctctg   1260

agcctgcgct gcataggact gagcagaccc acctcctcca gcttgggtgg ccctgccact   1320

cctggttcca agtctctcct ttcctggcag gtcttaaggg aagattgtac ccctcaccct   1380

ttacataccc agaatcatca gtatgtcact tcctaatttc tatcagtgta tctcattatt   1440

tcatactgtt ttactaatcc taagtctaaa cagatttgct caaaaggaga ccattctatt   1500

ttttaaagta cttagtgata cacgtataag ctttgcatgg acgaattaaa taagcacatt   1560

gaccttttct tgtacattca gaacctgaac atccatgtga aaactgggtc catttttgag   1620

agatgtgaaa ctacagttta tttgtaataa ataaatataa tctaaaaaaa aaaaaaaaa    1679


<210>  626
<211>  289
<212>  PRT
<213>  Homosapiens

<400>  626

Met Glu Pro Ala Ala Gly Ile Gln Arg Arg Ser Ser Gln Gly Pro Thr 
1               5                   10                  15      


Val Pro Pro Pro Pro Arg Gly His Ala Pro Pro Ala Ala Ala Pro Gly 
            20                  25                  30          


Pro Ala Pro Leu Ser Ser Pro Val Arg Glu Pro Pro Gln Leu Glu Glu 
        35                  40                  45              


Glu Arg Gln Val Arg Ile Ser Glu Ser Gly Gln Phe Ser Asp Gly Leu 
    50                  55                  60                  


Glu Asp Arg Gly Leu Leu Glu Ser Ser Thr Arg Leu Lys Pro His Glu 
65                  70                  75                  80  


Ala Gln Asn Tyr Arg Lys Lys Ala Leu Trp Val Ser Trp Phe Ser Ile 
                85                  90                  95      


Ile Val Thr Leu Ala Leu Ala Val Ala Ala Phe Thr Val Ser Val Met 
            100                 105                 110         


Arg Tyr Ser Ala Ser Ala Phe Gly Phe Ala Phe Asp Ala Ile Leu Asp 
        115                 120                 125             


Val Leu Ser Ser Ala Ile Val Leu Trp Arg Tyr Ser Asn Ala Ala Ala 
    130                 135                 140                 


Val His Ser Ala His Arg Glu Tyr Ile Ala Cys Val Ile Leu Gly Val 
145                 150                 155                 160 


Ile Phe Leu Leu Ser Ser Ile Cys Ile Val Val Lys Ala Ile His Asp 
                165                 170                 175     


Leu Ser Thr Arg Leu Leu Pro Glu Val Asp Asp Phe Leu Phe Ser Val 
            180                 185                 190         


Ser Ile Leu Ser Gly Ile Leu Cys Ser Ile Leu Ala Val Leu Lys Phe 
        195                 200                 205             


Met Leu Gly Lys Val Leu Thr Ser Arg Ala Leu Ile Thr Asp Gly Phe 
    210                 215                 220                 


Asn Ser Leu Val Gly Gly Val Met Gly Phe Ser Ile Leu Leu Ser Ala 
225                 230                 235                 240 


Glu Val Phe Lys His Asp Ser Ala Val Trp Tyr Leu Asp Gly Ser Ile 
                245                 250                 255     


Gly Val Leu Ile Gly Leu Thr Ile Phe Ala Tyr Gly Val Lys Leu Leu 
            260                 265                 270         


Ile Asp Met Val Pro Arg Val Arg Gln Thr Arg His Tyr Glu Met Phe 
        275                 280                 285             


Glu 
    


<210>  627
<211>  5885
<212>  DNA
<213>  Homosapiens

<400>  627
atgggcctga tcaagcaggc actttattat ccaatgcgta actcagtaat ggatatatct     60

gatgagcagg ttttcattgc tagtttagaa agtccgtggg gaaggtgtac aggagactgt    120

ggtcccggag gagtccagag tcgggcagtg tggtgttttc atgttgacgg gtggacaagt    180

cacctgtcta actgtggtga gagcaacagg cctccaaagg aaagaagttg tttccgagtt    240

tgtgactggc acagtgacct ctttcagtgg gaggtttctg actggcacca ctgtgtgctt    300

gttccttacg ctcgcggtga agtcaagcct cggactgcag agtgtgtgac ggctcagcat    360

ggactgcagc accggatggt gcgctgcatt cagaagctga accgaactgt ggttgcaaat    420

gaaatatgcg aacactttgc ccttcagcct cctacagaac aggcttgcct cattccttgt    480

ccccgggatt gtgtagtatc tgagttctta ccatggtcca actgtagcaa gggatgtggg    540

aagaaattgc agcatagaac tcgcgcggtc atagctcccc ctctctttgg tggtttgcaa    600

tgtccaaatc tgactgagtc aagagcctgt gatgctccca tttcctgtcc tcttggggaa    660

gaggaatata catttagcct taaggttgga ccatggagta aatgcagact gcctcatctt    720

aaagaaatta atccaagcgg aagaactgtt ctggatttta actctgattc aaatgagcga    780

gtcaccttta aacatcaaag ttacaaagca catcatcatt cgaagtcttg ggcaatagag    840

ataggttatc aaacccggca ggtttcgtgt acaagaagtg atggacaaaa tgctatgtta    900

agcctttgcc ttcaagattc cttcccattg actgttcagt cctgcatcat gcccaaagac    960

tgtgaaacct cccagtggtc ctcctggagc ccctgctcca agacatgccg ttcagggagt   1020

ctcttgccag gatttaggag caggagccgg aacgtgaagc acatggctat tggaggtgga   1080

aaggagtgtc ctgaacttct tgagaaagag gcctgcattg ttgaaggaga acttctgcag   1140

caatgtccca ggtattcctg gagaacttct gaatggaaag aatgccaagt ctctctcctc   1200

ctcgagcagc aggatcccca ctggcatgtg acgggacccg tgtgtggcgg tgggatccag   1260

acccgggagg tgtactgtgc ccagagcgta ccagcagctg ccgcactgag ggccaaggaa   1320

gtctctagac ctgtggaaaa ggcattatgt gtgggacccg ccccgttgcc ctctcagctc   1380

tgcaatatcc cttgctctac ggactgcata gtatcttcct ggtcagcctg gggcctgtgc   1440

atccatgaaa actgtcatga tcctcagggg aaaaaaggat ttagaacgag gcagcgccat   1500

gtcctcatgg aatctacagg gcctgcaggg cattgccctc atttggtgga gtctgttcct   1560

tgtgaggatc caatgtgcta ccgatggctg gcatcagaag ggatctgttt ccctgatcat   1620

ggaaaatgtg gcctgggaca tcgtattctg aaggccgtct gccagaatga ccgcggagaa   1680

gatgtatcag ggagtctttg cccagttccc cctcctcctg agaggaagtc ttgtgaaatt   1740

ccctgccgaa tggactgtgt gctgagcgag tggacggagt ggtcatcctg ttcccagtcc   1800

tgttcaaata aaaactcaga tgggaaacag accaggtcaa gaactatcct ggcactggct   1860

ggggaaggtg gaaagccatg tccccctagt caggctctcc aagagcatcg tttgtgtaat   1920

gaccattcct gtatgcagct tcactgggag acatcgcctt ggggcccttg ttctgaggac   1980

acattggtaa ctgcccttaa tgcaaccatt ggctggaatg gagaagccac gtgtggtgta   2040

ggcattcaga ctcggagagt cttctgtgtc aagagtcacg tgggacaagt aatgaccaaa   2100

agatgtccag attctactcg acctgaaact gtgcgcccct gttttctccc atgcaaaaaa   2160

gactgtattg tgactgcttt cagtgagtgg acaccctgcc caaggatgtg ccaagcagga   2220

aatgccacag taaaacagtc tcgatacaga atcatcatcc aagaagcagc caatggaggc   2280

caggaatgcc cagatacctt atatgaggag agagagtgtg aagatgtttc cttgtgtcct   2340

gtatatcggt ggaagccaca gaaatggagc ccttgcatct tagtgccaga gtctgtctgg   2400

cagggaataa cgggcagcag tgaagcctgt ggaaaggggt tacaaacaag agctgtctca   2460

tgcatctctg atgacaaccg gtcagcagaa atgatggaat gcctcaagca gacaaacggc   2520

atgcctctcc ttgtgcaaga atgcacagtc ccatgtcgag aagactgcac cttcactgct   2580

tggtccaagt ttacgccctg ctccacgaac tgtgaagcca caaaaagtag gcggcgacag   2640

ctcacaggga aaagcagaaa gaaggagaaa tgccaggatt ctgaccttta ccctctagtg   2700

gagacagaac tatgtccttg tgatgaattt atatcccaac cttatggaaa ctggtcagat   2760

tgcattcttc cagaaggcag aagggagcct caccgaggac tgcgggtaca agcagacagc   2820

aaagaatgtg gagaaggcct gcgctttcga gcagtagcct gttctgataa aaatggaaga   2880

cctgttgacc cctccttctg cagcagctct ggttacattc aagaaaaatg tgtcattccc   2940

tgcccatttg attgcaagtt aagcgattgg tctagttggg ggtcttgcag ttcatcttgt   3000

ggaattggag tgagaattcg atccaaatgg ctaaaagaaa aaccttacaa tggaggacga   3060

ccatgtccca aactggatct caagaatcag gctcaggtac atgaggcagt cccatgttac   3120

agtgagtgca atcagtattc ctgggttgta gaacactggt cttcatgcaa aatcaacaat   3180

gagctgaggt ccctgcgctg tggaggagga acacaatcta ggaaaatcag atgtgtgaat   3240

actgcggatg gtgaaggtgg agcagtggat agcaacctgt gcaaccagga tgaaattccc   3300

ccagaaaccc agtcctgttc tcttatgtgt cccaatgagt gtgtcatgtc tgagtgggga   3360

ctttggagca aatgcccaca gtcatgcgat ccccacacaa tgcagagaag aactcgccac   3420

ctgctaagac catcactgaa ctcaaggact tgtgctgaag actcacaggt gcagccttgc   3480

ctcctgaatg aaaattgctt ccagttccag tacaatctaa cagagtggag cacatgccag   3540

ctgagtgaaa acgcaccctg tggtcaaggc gtcaggaccc gcctgctaag ctgtgtgtgc   3600

agtgatggca agccagtcag catggaccaa tgtgagcagc ataatttgga gaagccccag   3660

agaatgagca ttccctgctt ggtggaatgc gtggtcaact gtcagctctc agggtggacg   3720

gcttggacag agtgttcaca gacctgtggc catggaggtc gaatgagccg gactcgattt   3780

atcattatgc caacccaagg agaaggacgg ccatgcccca cagagcttac ccaggagaaa   3840

acctgcccag tgaccccctg ctacagctgg gtccttggca actggtctgc atgtaaattg   3900

gagggtggag actgtgggga aggagttcag atccgcagcc tttcctgcat ggtccacagt   3960

ggttcaatat ctcatgcagc tggacgtgtc gaggatgcac tgtgtggaga aatgcccttt   4020

caggacagca tcctgaagca gctgtgttct gtgccttgcc caggagactg ccatttaaca   4080

gaatggtcag agtggagcac atgtgaatta acctgcattg atggaagaag ctttgagact   4140

gtgggccgcc agtctagatc aaggactttt ataattcagt cttttgagaa ccaagacagc   4200

tgcccccaac aggttctaga aacacgccct tgtacaggag gcaaatgtta tcactacaca   4260

tggaaagcaa gtctttggaa caataacgaa cgaactgtat ggtgccagcg ttcagatggc   4320

gttaatgtca caggaggctg ctcccctcag gcccgtcctg ctgccattcg gcagtgcatt   4380

ccagcctgca gaaaaccttt ctcctactgt acacagggtg gagtctgtgg ttgtgagaag   4440

ggctatacag agataatgaa atcaaatggt ttcctggatt actgcatgaa agtaccaggc   4500

tcagaggata aaaaagctga tgtgaaaaac ctttctggga aaaacagacc tgtgaattca   4560

aaaatacatg atatttttaa aggatggtct cttcaaccac ttgatccaga tggccgagta   4620

aaaatttggg tttatggcgt ttcaggtggc gcttttctca tcatgatttt cctaatattt   4680

acttcctacc ttgtttgcaa gaagccaaaa ccacatcaaa gcacacctcc ccaacagaag   4740

cctctgacct tagcctacga tggagactta gacatgtaat ctgaaaaaga aatccaaatg   4800

tagacatcaa ctgccttaac cgctttctct tttgtagctc tcagacttct cagttttttg   4860

aggaatctca agatgtgata tattgggcag aatacaaata ttgcaaaagt aatattgcct   4920

caacttcatt tggacatgga gtcaaggatt attaggtctg ccattttgtt ttcaagttgt   4980

ttgtgggtgt gttttatttt tttggttttc ccaagggacc tgaaaaccct tctcttcctg   5040

tttggaactg ggaggaagaa aacatgatgg aattcccaca gacttgagta aacttgatct   5100

tcagcagcat aatgacaatc cagaggaaaa tacagtcaag gcatttactc taaatgacga   5160

gtctgacact gcattgttac gcactatatt agtgcaaagt ctttattctt cccatacttc   5220

aacactgagt tttctagagt ttactttggt ttaaagactt tcaaattgga ttgcctattt   5280

ttcatgaaca cagagagaat ggattaccat ttcagaaatt ctctgagttt ttaaccttta   5340

aatattgtat tttgttttgt agccagggga tgatggcgct tcatgggttg cagctactga   5400

aaatagcagc gtgtgtgtaa ttgctggact agatgaaagc taggtcattt ctgaagggaa   5460

tgtgtactga atgttagagt gtacaaatga aatatgtggt taaattggag aatgaggtag   5520

attatttgat tactaaaact gtattttaac aaaaacttat ccatgtagat atagcattaa   5580

ccacacacag ttgtaattca gtttaatgat gacaaactct gcttttgtaa tttcaatttt   5640

cttatctgaa tatttataaa ttcttctttc aaatttaatt atctgacctc atttaatata   5700

catcaaacac cgatcctgtt tgtacaaagt cttgctttta taaggtttca ataatatcta   5760

aaacaacaca ttaaaaagct gagaccattt tatgaagata attgtttgta atcataggtg   5820

ttgaaagtaa aaaggtgcca tcttgtggta ttgacttgta tttataacaa ataaactgct   5880

caaga                                                               5885


<210>  628
<211>  1592
<212>  PRT
<213>  Homosapiens

<400>  628

Met Gly Leu Ile Lys Gln Ala Leu Tyr Tyr Pro Met Arg Asn Ser Val 
1               5                   10                  15      


Met Asp Ile Ser Asp Glu Gln Val Phe Ile Ala Ser Leu Glu Ser Pro 
            20                  25                  30          


Trp Gly Arg Cys Thr Gly Asp Cys Gly Pro Gly Gly Val Gln Ser Arg 
        35                  40                  45              


Ala Val Trp Cys Phe His Val Asp Gly Trp Thr Ser His Leu Ser Asn 
    50                  55                  60                  


Cys Gly Glu Ser Asn Arg Pro Pro Lys Glu Arg Ser Cys Phe Arg Val 
65                  70                  75                  80  


Cys Asp Trp His Ser Asp Leu Phe Gln Trp Glu Val Ser Asp Trp His 
                85                  90                  95      


His Cys Val Leu Val Pro Tyr Ala Arg Gly Glu Val Lys Pro Arg Thr 
            100                 105                 110         


Ala Glu Cys Val Thr Ala Gln His Gly Leu Gln His Arg Met Val Arg 
        115                 120                 125             


Cys Ile Gln Lys Leu Asn Arg Thr Val Val Ala Asn Glu Ile Cys Glu 
    130                 135                 140                 


His Phe Ala Leu Gln Pro Pro Thr Glu Gln Ala Cys Leu Ile Pro Cys 
145                 150                 155                 160 


Pro Arg Asp Cys Val Val Ser Glu Phe Leu Pro Trp Ser Asn Cys Ser 
                165                 170                 175     


Lys Gly Cys Gly Lys Lys Leu Gln His Arg Thr Arg Ala Val Ile Ala 
            180                 185                 190         


Pro Pro Leu Phe Gly Gly Leu Gln Cys Pro Asn Leu Thr Glu Ser Arg 
        195                 200                 205             


Ala Cys Asp Ala Pro Ile Ser Cys Pro Leu Gly Glu Glu Glu Tyr Thr 
    210                 215                 220                 


Phe Ser Leu Lys Val Gly Pro Trp Ser Lys Cys Arg Leu Pro His Leu 
225                 230                 235                 240 


Lys Glu Ile Asn Pro Ser Gly Arg Thr Val Leu Asp Phe Asn Ser Asp 
                245                 250                 255     


Ser Asn Glu Arg Val Thr Phe Lys His Gln Ser Tyr Lys Ala His His 
            260                 265                 270         


His Ser Lys Ser Trp Ala Ile Glu Ile Gly Tyr Gln Thr Arg Gln Val 
        275                 280                 285             


Ser Cys Thr Arg Ser Asp Gly Gln Asn Ala Met Leu Ser Leu Cys Leu 
    290                 295                 300                 


Gln Asp Ser Phe Pro Leu Thr Val Gln Ser Cys Ile Met Pro Lys Asp 
305                 310                 315                 320 


Cys Glu Thr Ser Gln Trp Ser Ser Trp Ser Pro Cys Ser Lys Thr Cys 
                325                 330                 335     


Arg Ser Gly Ser Leu Leu Pro Gly Phe Arg Ser Arg Ser Arg Asn Val 
            340                 345                 350         


Lys His Met Ala Ile Gly Gly Gly Lys Glu Cys Pro Glu Leu Leu Glu 
        355                 360                 365             


Lys Glu Ala Cys Ile Val Glu Gly Glu Leu Leu Gln Gln Cys Pro Arg 
    370                 375                 380                 


Tyr Ser Trp Arg Thr Ser Glu Trp Lys Glu Cys Gln Val Ser Leu Leu 
385                 390                 395                 400 


Leu Glu Gln Gln Asp Pro His Trp His Val Thr Gly Pro Val Cys Gly 
                405                 410                 415     


Gly Gly Ile Gln Thr Arg Glu Val Tyr Cys Ala Gln Ser Val Pro Ala 
            420                 425                 430         


Ala Ala Ala Leu Arg Ala Lys Glu Val Ser Arg Pro Val Glu Lys Ala 
        435                 440                 445             


Leu Cys Val Gly Pro Ala Pro Leu Pro Ser Gln Leu Cys Asn Ile Pro 
    450                 455                 460                 


Cys Ser Thr Asp Cys Ile Val Ser Ser Trp Ser Ala Trp Gly Leu Cys 
465                 470                 475                 480 


Ile His Glu Asn Cys His Asp Pro Gln Gly Lys Lys Gly Phe Arg Thr 
                485                 490                 495     


Arg Gln Arg His Val Leu Met Glu Ser Thr Gly Pro Ala Gly His Cys 
            500                 505                 510         


Pro His Leu Val Glu Ser Val Pro Cys Glu Asp Pro Met Cys Tyr Arg 
        515                 520                 525             


Trp Leu Ala Ser Glu Gly Ile Cys Phe Pro Asp His Gly Lys Cys Gly 
    530                 535                 540                 


Leu Gly His Arg Ile Leu Lys Ala Val Cys Gln Asn Asp Arg Gly Glu 
545                 550                 555                 560 


Asp Val Ser Gly Ser Leu Cys Pro Val Pro Pro Pro Pro Glu Arg Lys 
                565                 570                 575     


Ser Cys Glu Ile Pro Cys Arg Met Asp Cys Val Leu Ser Glu Trp Thr 
            580                 585                 590         


Glu Trp Ser Ser Cys Ser Gln Ser Cys Ser Asn Lys Asn Ser Asp Gly 
        595                 600                 605             


Lys Gln Thr Arg Ser Arg Thr Ile Leu Ala Leu Ala Gly Glu Gly Gly 
    610                 615                 620                 


Lys Pro Cys Pro Pro Ser Gln Ala Leu Gln Glu His Arg Leu Cys Asn 
625                 630                 635                 640 


Asp His Ser Cys Met Gln Leu His Trp Glu Thr Ser Pro Trp Gly Pro 
                645                 650                 655     


Cys Ser Glu Asp Thr Leu Val Thr Ala Leu Asn Ala Thr Ile Gly Trp 
            660                 665                 670         


Asn Gly Glu Ala Thr Cys Gly Val Gly Ile Gln Thr Arg Arg Val Phe 
        675                 680                 685             


Cys Val Lys Ser His Val Gly Gln Val Met Thr Lys Arg Cys Pro Asp 
    690                 695                 700                 


Ser Thr Arg Pro Glu Thr Val Arg Pro Cys Phe Leu Pro Cys Lys Lys 
705                 710                 715                 720 


Asp Cys Ile Val Thr Ala Phe Ser Glu Trp Thr Pro Cys Pro Arg Met 
                725                 730                 735     


Cys Gln Ala Gly Asn Ala Thr Val Lys Gln Ser Arg Tyr Arg Ile Ile 
            740                 745                 750         


Ile Gln Glu Ala Ala Asn Gly Gly Gln Glu Cys Pro Asp Thr Leu Tyr 
        755                 760                 765             


Glu Glu Arg Glu Cys Glu Asp Val Ser Leu Cys Pro Val Tyr Arg Trp 
    770                 775                 780                 


Lys Pro Gln Lys Trp Ser Pro Cys Ile Leu Val Pro Glu Ser Val Trp 
785                 790                 795                 800 


Gln Gly Ile Thr Gly Ser Ser Glu Ala Cys Gly Lys Gly Leu Gln Thr 
                805                 810                 815     


Arg Ala Val Ser Cys Ile Ser Asp Asp Asn Arg Ser Ala Glu Met Met 
            820                 825                 830         


Glu Cys Leu Lys Gln Thr Asn Gly Met Pro Leu Leu Val Gln Glu Cys 
        835                 840                 845             


Thr Val Pro Cys Arg Glu Asp Cys Thr Phe Thr Ala Trp Ser Lys Phe 
    850                 855                 860                 


Thr Pro Cys Ser Thr Asn Cys Glu Ala Thr Lys Ser Arg Arg Arg Gln 
865                 870                 875                 880 


Leu Thr Gly Lys Ser Arg Lys Lys Glu Lys Cys Gln Asp Ser Asp Leu 
                885                 890                 895     


Tyr Pro Leu Val Glu Thr Glu Leu Cys Pro Cys Asp Glu Phe Ile Ser 
            900                 905                 910         


Gln Pro Tyr Gly Asn Trp Ser Asp Cys Ile Leu Pro Glu Gly Arg Arg 
        915                 920                 925             


Glu Pro His Arg Gly Leu Arg Val Gln Ala Asp Ser Lys Glu Cys Gly 
    930                 935                 940                 


Glu Gly Leu Arg Phe Arg Ala Val Ala Cys Ser Asp Lys Asn Gly Arg 
945                 950                 955                 960 


Pro Val Asp Pro Ser Phe Cys Ser Ser Ser Gly Tyr Ile Gln Glu Lys 
                965                 970                 975     


Cys Val Ile Pro Cys Pro Phe Asp Cys Lys Leu Ser Asp Trp Ser Ser 
            980                 985                 990         


Trp Gly Ser Cys Ser Ser Ser Cys  Gly Ile Gly Val Arg  Ile Arg Ser 
        995                 1000                 1005             


Lys Trp  Leu Lys Glu Lys Pro  Tyr Asn Gly Gly Arg  Pro Cys Pro 
    1010                 1015                 1020             


Lys Leu  Asp Leu Lys Asn Gln  Ala Gln Val His Glu  Ala Val Pro 
    1025                 1030                 1035             


Cys Tyr  Ser Glu Cys Asn Gln  Tyr Ser Trp Val Val  Glu His Trp 
    1040                 1045                 1050             


Ser Ser  Cys Lys Ile Asn Asn  Glu Leu Arg Ser Leu  Arg Cys Gly 
    1055                 1060                 1065             


Gly Gly  Thr Gln Ser Arg Lys  Ile Arg Cys Val Asn  Thr Ala Asp 
    1070                 1075                 1080             


Gly Glu  Gly Gly Ala Val Asp  Ser Asn Leu Cys Asn  Gln Asp Glu 
    1085                 1090                 1095             


Ile Pro  Pro Glu Thr Gln Ser  Cys Ser Leu Met Cys  Pro Asn Glu 
    1100                 1105                 1110             


Cys Val  Met Ser Glu Trp Gly  Leu Trp Ser Lys Cys  Pro Gln Ser 
    1115                 1120                 1125             


Cys Asp  Pro His Thr Met Gln  Arg Arg Thr Arg His  Leu Leu Arg 
    1130                 1135                 1140             


Pro Ser  Leu Asn Ser Arg Thr  Cys Ala Glu Asp Ser  Gln Val Gln 
    1145                 1150                 1155             


Pro Cys  Leu Leu Asn Glu Asn  Cys Phe Gln Phe Gln  Tyr Asn Leu 
    1160                 1165                 1170             


Thr Glu  Trp Ser Thr Cys Gln  Leu Ser Glu Asn Ala  Pro Cys Gly 
    1175                 1180                 1185             


Gln Gly  Val Arg Thr Arg Leu  Leu Ser Cys Val Cys  Ser Asp Gly 
    1190                 1195                 1200             


Lys Pro  Val Ser Met Asp Gln  Cys Glu Gln His Asn  Leu Glu Lys 
    1205                 1210                 1215             


Pro Gln  Arg Met Ser Ile Pro  Cys Leu Val Glu Cys  Val Val Asn 
    1220                 1225                 1230             


Cys Gln  Leu Ser Gly Trp Thr  Ala Trp Thr Glu Cys  Ser Gln Thr 
    1235                 1240                 1245             


Cys Gly  His Gly Gly Arg Met  Ser Arg Thr Arg Phe  Ile Ile Met 
    1250                 1255                 1260             


Pro Thr  Gln Gly Glu Gly Arg  Pro Cys Pro Thr Glu  Leu Thr Gln 
    1265                 1270                 1275             


Glu Lys  Thr Cys Pro Val Thr  Pro Cys Tyr Ser Trp  Val Leu Gly 
    1280                 1285                 1290             


Asn Trp  Ser Ala Cys Lys Leu  Glu Gly Gly Asp Cys  Gly Glu Gly 
    1295                 1300                 1305             


Val Gln  Ile Arg Ser Leu Ser  Cys Met Val His Ser  Gly Ser Ile 
    1310                 1315                 1320             


Ser His  Ala Ala Gly Arg Val  Glu Asp Ala Leu Cys  Gly Glu Met 
    1325                 1330                 1335             


Pro Phe  Gln Asp Ser Ile Leu  Lys Gln Leu Cys Ser  Val Pro Cys 
    1340                 1345                 1350             


Pro Gly  Asp Cys His Leu Thr  Glu Trp Ser Glu Trp  Ser Thr Cys 
    1355                 1360                 1365             


Glu Leu  Thr Cys Ile Asp Gly  Arg Ser Phe Glu Thr  Val Gly Arg 
    1370                 1375                 1380             


Gln Ser  Arg Ser Arg Thr Phe  Ile Ile Gln Ser Phe  Glu Asn Gln 
    1385                 1390                 1395             


Asp Ser  Cys Pro Gln Gln Val  Leu Glu Thr Arg Pro  Cys Thr Gly 
    1400                 1405                 1410             


Gly Lys  Cys Tyr His Tyr Thr  Trp Lys Ala Ser Leu  Trp Asn Asn 
    1415                 1420                 1425             


Asn Glu  Arg Thr Val Trp Cys  Gln Arg Ser Asp Gly  Val Asn Val 
    1430                 1435                 1440             


Thr Gly  Gly Cys Ser Pro Gln  Ala Arg Pro Ala Ala  Ile Arg Gln 
    1445                 1450                 1455             


Cys Ile  Pro Ala Cys Arg Lys  Pro Phe Ser Tyr Cys  Thr Gln Gly 
    1460                 1465                 1470             


Gly Val  Cys Gly Cys Glu Lys  Gly Tyr Thr Glu Ile  Met Lys Ser 
    1475                 1480                 1485             


Asn Gly  Phe Leu Asp Tyr Cys  Met Lys Val Pro Gly  Ser Glu Asp 
    1490                 1495                 1500             


Lys Lys  Ala Asp Val Lys Asn  Leu Ser Gly Lys Asn  Arg Pro Val 
    1505                 1510                 1515             


Asn Ser  Lys Ile His Asp Ile  Phe Lys Gly Trp Ser  Leu Gln Pro 
    1520                 1525                 1530             


Leu Asp  Pro Asp Gly Arg Val  Lys Ile Trp Val Tyr  Gly Val Ser 
    1535                 1540                 1545             


Gly Gly  Ala Phe Leu Ile Met  Ile Phe Leu Ile Phe  Thr Ser Tyr 
    1550                 1555                 1560             


Leu Val  Cys Lys Lys Pro Lys  Pro His Gln Ser Thr  Pro Pro Gln 
    1565                 1570                 1575             


Gln Lys  Pro Leu Thr Leu Ala  Tyr Asp Gly Asp Leu  Asp Met 
    1580                 1585                 1590         


<210>  629
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  629
gtgataaaac tacaaagcag aatacgaaga agacagaggc aaaggcttct tccctcagac     60

cataactcaa gaatatgggg gtctcgcagt aatttatgct ctttgctttt gtcttttcat    120

agttttcctt gtatagtttg tcacttaggg catctcctgc tgccttcagc tgcctaagct    180

gtgggttctc tgaagcagga agcacattat aatctgcttt tcctttattc ttttcatagt    240

cttctttgta ttttgctgct gaggaaattt atttggtaga ttgaaggttt gaacgagagc    300

tacagaaacg aaagaaaaag tctgtataag ccaatggtgt tcgggaagaa aataacccca    360

ttgccttgag tttgtaggtg ccactactac tctgaaaaat ggcagatgac gaagactatg    420

aggaggtggt ggagtactac acagaagaag tggtttacga agaggtgccg ggagagacaa    480

taacaaaaat ttatgagact acgacaacaa ggacatctga ctatgagcaa tcagaaactt    540

ccaaaccagc tctggcacag ccagcactgg cacagccagc atcagcaaag ccggtggaga    600

ggaggaaggt catccggaag aaagtggatc cttcaaagtt catgaccccc tacattgcac    660

acagtcagaa aatgcaggat ctttttagcc caaataaata caaggagaag tttgagaaaa    720

caaaaggaca gccatacgcc agcacaacag atactccaga acttcgcaga atcaaaaaag    780

tacaagatca actcagtgag gttaagtatc gaatggatgg tgatgttgct aagactatat    840

gtcacgtaga tgaaaaagca aaggatattg aacatgcaaa gaaagtgtcg cagcaagtca    900

gtaaggtttt atacaagcag aactgggaag acaccaagga taagtacctg cttcctcctg    960

atgcccctga acttgtccag gccgttaaga acaccgccat gttcagcaag aaactgtaca   1020

ctgaagactg ggaagcagac aaaagtttgt tttaccccta taatgatagc ccggaactga   1080

ggagagttgc ccaggcccag aaagctctca gtgatgttgc ctacaaaaaa ggtctcgctg   1140

aacagcaagc tcaattcacg cctctggccg atcctccaga tatagaattt gccaagaaag   1200

taaccaatca agtgagcaag caaaaataca aagaagacta tgaaaataaa atcaaaggca   1260

aatggagtga gacaccttgc tttgaagttg caaatgccag aatgaatgct gataacatta   1320

gcacaaggaa ataccaggaa gattttgaaa acatgaaaga ccagatctac ttcatgcaga   1380

ccgaaacacc agagtataaa atgaataaaa aagctggtgt ggcagctagc aaggtaaaat   1440

acaaagaaga ctatgaaaag aataaaggaa aagcagatta taatgtgctt cctgcttcag   1500

agaacccaca gcttaggcag ctgaaggcag caggagatgc cctaagtgac aaactataca   1560

aggaaaacta tgaaaagaca aaagcaaaga gcataaatta ctgcgagacc cccaaattca   1620

agctcgatac tgttctgcag aacttcagta gtgataaaaa atataaagat tcctacttaa   1680

aagatatttt gggacattat gtaggcagct tcgaggatcc ataccattca cactgcatga   1740

aagtcacagc tcaaaacagt gataaaaact acaaagcaga atacgaagaa gacagaggca   1800

aaggcttctt ccctcagacc ataactcaag aatatgaagc aattaagaaa ctagatcagt   1860

gtaaagacca cacctacaaa gtccatccag ataagacaaa attcacccaa gttacagact   1920

ctcctgttct gctacaagcc caagtcaatt ccaaacaact gagtgactta aattacaaag   1980

caaaacatga aagtgaaaag ttcaagtgcc atatcccccc tgatactcct gcttttatcc   2040

agcacaaagt caatgcctat aacttgagtg ataatcttta taagcaagac tgggagaaga   2100

gcaaagccaa aaagtttgac attaaagtgg atgccattcc cctgctggca gccaaagcca   2160

acaccaagaa caccagcgat gtgatgtaca agaaagacta tgaaaaaaac aaagggaaaa   2220

tgattggagt cctcagcatt aatgacgatc ccaagatgct gcactccttg aaggtggcca   2280

aaaaccagag tgatagatta tacaaggaaa actatgagaa gacaaaggca aagagtatga   2340

attactgtga gaccccaaaa tatcaacttg atactcagct gaagaacttc agtgaggcta   2400

gatataaaga cttatatgta aaggatgttt tgggacatta tgtaggcagc atggaggacc   2460

catatcacac acactgcatg aaagttgcag ctcaaaacag tgataaaagt tacaaagcag   2520

aatatgaaga agataaagga aaatgctatt tccctcagac aataacacaa gaatatgacg   2580

caatcaagaa gctggaccag tgtaaagatc atacctacaa agttcatcca gataagacca   2640

aattcacggc agtcactgat tctcctgtac tgttgcaagc ccagctcaac acgaaacagc   2700

ttagtgatct gaattacaaa gcaaaacatg aaggtgagag gttcaagtgc catataccag   2760

cagatgctcc acagtttatc caacacagag tcaatgccta taatctgagt gataatgttt   2820

ataagcaaga ctgggagaag agcaaagcca agaagtttga cattaaagtg gacgccattc   2880

ccctgttggc agccaaagcc aacaccaaga acaccagcga tgtgatgtac aagaaagact   2940

atgaaaagag caaagggaaa atgattggag ccctcagcat taatgacgat ccaaagatgc   3000

tgcactcctt gaagacagcc aaaaaccaga gtgatcgcga atatcgaaaa gattatgaaa   3060

agtcaaaaac tatctacacg gcacctcttg atatgctcca agtcactcaa gctaagaaat   3120

ctcaggcaat tgccagcgac gttgattata agcacatctt acacagttac agctaccccc   3180

ctgatagcat caatgtggac cttgccaaga aggcatatgc gctgcagagc gatgttgaat   3240

acaaagctga ctacaatagc tggatgaaag gttgtggctg ggtgcctttt gggtccttag   3300

aaatggaaaa ggcaaagcga gcttcagaca tcctcaatga gaaaaaatat cgccaacatc   3360

cagacaccct caagtttacc tcgattgaag atgctccaat tacagtacag tctaaaatta   3420

accaggccca gaggagtgat atcgcttaca aagccaaagg agaggaaatt attcacaatt   3480

acaacctgcc accagacctg ccccagttca tccaggctaa agttaatgcc tacaatatca   3540

gtgagaatat gtacaaagca gacttgaaag acttgagcaa gaagggatat gacctgagaa   3600

ctgatgcgat tcccatcaga gctgccaaag ctgccaggca ggcggcgagt gacgttcagt   3660

acaaaaaaga ctatgaaaag gctaaaggga aaatggttgg cttccaaagt cttcaagatg   3720

accctaaact ggttcattat atgaacgtgg ccaagataca atcagatcgg gagtataaaa   3780

aagactatga gaagacaaag tccaaataca acacgcccca tgatatgttc aatgtcgtgg   3840

cggctaagaa agcccaggat gtggtcagca atgtcaacta taagcattct ctccatcatt   3900

acacctactt gcctgacgcc atggacctgg agctgtctaa gaacatgatg cagatacaga   3960

gtgataacgt ctacaaggaa gactacaaca actggatgaa aggcattggc tggattccta   4020

ttggcagtct cgacgtcgaa aaagttaaaa aggccggtga tgctctgaat gaaaagaagt   4080

acaggcaaca tccagacacc ctcaaattta ccagcattgt ggactcccca gttatggtcc   4140

aggcaaaaca gaacacgaag caagtcagtg atatcttata caaggctaaa ggagaagatg   4200

tgaaacataa atacaccatg agtcctgatc ttcctcagtt tctccaggcc aagtgcaatg   4260

cttacagtat aagtgacgtc tgttataaac gggattggca tgacttaata cgcaagggca   4320

acaatgtgct gggcgatgct attcccatca ctgcagccaa ggcatcgaga aacattgcca   4380

gtgattataa atacaaggaa gcttatgaga agtcaaaggg aaagcatgtg ggtttcagaa   4440

gcctccagga tgatcccaag ctggtccact atatgaatgt ggcaaagctg cagtctgatc   4500

gtgaatacaa gaagaactat gagaacacca aaaccagcta ccatacccct ggggacatgg   4560

ttacgatcac agctgcaaag atggcccagg atgtcgctac caatgtcaac tacaaacagc   4620

cattgcatca ttacacatac ctacctgacg ccatgagtct tgagcatacg aggaatgtca   4680

atcaaattca gagtgataat gtgtataaag acgagtataa cagcttcttg aagggcatcg   4740

gatggatccc tattggttcc ctggaggtgg agaaggtcaa gaaagcaggc gatgcattaa   4800

atgagaggaa gtatcgacag cacccagata ccgtcaagtt cacaagtgtg cctgattcca   4860

tgggcatgat gttggctcag cataacacaa agcagctaag tgatttgaac tacaaggtag   4920

agggagagaa actgaagcac aagtatacta ttgaccctga attgcctcag tttattcaag   4980

ccaaagtcaa cgccctcaac atgagtgatg ctcattataa agcagattgg aagaaaacca   5040

ttcgcaaggg ctatgatttg agaccagatg ccatcccaat tgttgctgca aaaagttcaa   5100

ggaatattgc tagtgattgc aaatataagg aggcctacga gaaagccaaa ggcaagcaag   5160

ttggatttct cagtcttcag gatgatccta aactggttca ctacatgaat gtggccaaaa   5220

tccagtctga tcgtgagtac aaaaagggct atgaagccag caagaccaag taccacacac   5280

ctctggatat ggtcagtgtg acagctgcaa agaaatctca ggaggttgcc accaacgcca   5340

actacagaca gtcataccac cactacactc tcctgcccga tgccttgaat gtggagcact   5400

ccaggaatgc catgcagatt cagagtgata atctgtacaa atctgacttc accaattgga   5460

tgaaagggat cggctgggtg cccatagagt ccctggaggt ggagaaggca aagaaagcag   5520

gagagattct tagtgagaag aagtatcgcc agcaccccga gaagctgaag ttcacttacg   5580

ccatggacac aatggaacag gcacttaaca agagtaacaa actgaacatg gacaagaggc   5640

tctacactga aaaatggaac aaggacaaga ccaccattca tgtcatgcct gacacaccgg   5700

atattttact ctccagagta aaccaaatca ccatgagtga taaactgtac aaagctggct   5760

gggaagagga aaagaagaaa ggatatgacc tgaggcctga tgccattgca ataaaggctg   5820

caagagcctc tagagacatt gccagtgatt acaaatacaa gaaagcctat gaacaagcca   5880

aagggaaaca cattggcttc cggagcctgg aagatgaccc caagctggtg cacttcatgc   5940

aagtggccaa gatgcagtca gaccgggaat acaagaaggg atatgagaaa tccaagacct   6000

ccttccacac cccggtggac atgctcagtg tggtggcagc caagaagtct caggaagtgg   6060

ccaccaatgc caactacagg aacgtgatcc atacctacaa catgcttcct gatgccatga   6120

gctttgaatt ggccaaaaat atgatgcaga ttcaaagtga taatcagtac aaggctgact   6180

atgctgactt catgaagggc attggatggc tccctctggg ctccctggaa gcagagaaaa   6240

acaagaaagc catggagatt attagtgaaa agaagtaccg ccagcaccca gacactttga   6300

agtattccac actcatggac tcgatgaaca tggttttggc ccagaataat gcaaaaatta   6360

tgaacgaaca tctctacaaa caagcatggg aggctgacaa aaccaaagtc cacatcatgc   6420

ctgatatccc ccagattatt ttggcaaagg caaatgcaat taatataagt gataaactct   6480

acaaactttc cttggaagag tctaaaaaga aaggctatga tctcagacct gatgcaattc   6540

ctatcaaagc tgccaaggct tccagagata ttgcaagtga ttataaatac aagtacaatt   6600

atgaaaaagg gaaggggaaa atggttggtt tccgcagtct cgaggatgat cccaaattag   6660

tccattccat gcaagtggct aagatgcaat ctgatcggga gtacaagaaa aactatgaga   6720

acacaaagac cagctaccac acccctgccg acatgctcag tgtcacggct gcaaaggatg   6780

cccaagccaa catcaccaac actaactaca agcacctgat tcacaagtac atcctccttc   6840

cagatgcaat gaacattgag ctgaccagga atatgaatcg catacagagt gataatgaat   6900

ataagcaaga ttacaatgaa tggtacaaag ggcttggctg gagtccagca ggttctctgg   6960

aagtggagaa ggccaagaaa gcaactgaat atgccagtga tcagaaatac cgccagcacc   7020

cgagcaactt ccagtttaag aagctgactg attccatgga catggtgctt gccaagcaga   7080

atgcacatac catgaacaag catttataca ccattgattg gaataaagat aagaccaaga   7140

ttcatgtgat gcctgataca ccagatattt tacaagccaa gcagaatcaa acactgtata   7200

gtcagaaact ctataaactt ggatgggaag aagctttgaa gaaaggctat gatctcccag   7260

ttgatgcaat ttctgtacag ctagctaaag cttcaagaga cattgctagt gattataaat   7320

acaaacaagg ctaccgaaag caacttggcc accatgttgg attccggagt ctgcaagatg   7380

acccaaaact tgtgttgtcc atgaatgtag ccaaaatgca gagtgaaaga gaatacaaga   7440

aggactttga gaagtggaaa actaagttct ccagcccagt ggacatgttg ggagtggtac   7500

tggccaagaa gtgtcaggag ttggttagtg acgtggacta caagaactac ctgcatcagt   7560

ggacatgtct gcctgatcag aacgatgttg tgcaagctaa gaaagtttat gaactgcaaa   7620

gtgagaatct atataaatct gaccttgagt ggctgagagg cataggatgg agtcccttgg   7680

gttctttaga ggcagaaaag aacaagcggg cttcggaaat catcagtgag aagaaatatc   7740

gtcagcctcc agacagaaac aagttcacca gcattcctga tgccatggat atagttctgg   7800

caaagacaaa tgccaaaaat aggagtgata gactttatag agaagcttgg gacaaagaca   7860

agactcagat ccacatcatg cctgatacac ctgacattgt tctggctaaa gcaaacttaa   7920

tcaacacaag tgataaactc taccgaatgg gttatgagga gctgaagaga aaaggttacg   7980

atcttcctgt tgatgccata ccaatcaaag cagcaaaagc ctcccgggaa attgccagtg   8040

aatacaagta caaggaaggc tttcgcaagc agctcggcca ccacattggt gcccggaaca   8100

ttgaagatga ccccaagatg atgtggtcca tgcatgtggc caagatccag agtgacaggg   8160

agtacaagaa ggactttgag aagtggaaga cc                                 8192


<210>  630
<211>  6669
<212>  PRT
<213>  Homosapiens

<400>  630

Met Ala Asp Asp Glu Asp Tyr Glu Glu Val Val Glu Tyr Tyr Thr Glu 
1               5                   10                  15      


Glu Val Val Tyr Glu Glu Val Pro Gly Glu Thr Ile Thr Lys Ile Tyr 
            20                  25                  30          


Glu Thr Thr Thr Thr Arg Thr Ser Asp Tyr Glu Gln Ser Glu Thr Ser 
        35                  40                  45              


Lys Pro Ala Leu Ala Gln Pro Ala Leu Ala Gln Pro Ala Ser Ala Lys 
    50                  55                  60                  


Pro Val Glu Arg Arg Lys Val Ile Arg Lys Lys Val Asp Pro Ser Lys 
65                  70                  75                  80  


Phe Met Thr Pro Tyr Ile Ala His Ser Gln Lys Met Gln Asp Leu Phe 
                85                  90                  95      


Ser Pro Asn Lys Tyr Lys Glu Lys Phe Glu Lys Thr Lys Gly Gln Pro 
            100                 105                 110         


Tyr Ala Ser Thr Thr Asp Thr Pro Glu Leu Arg Arg Ile Lys Lys Val 
        115                 120                 125             


Gln Asp Gln Leu Ser Glu Val Lys Tyr Arg Met Asp Gly Asp Val Ala 
    130                 135                 140                 


Lys Thr Ile Cys His Val Asp Glu Lys Ala Lys Asp Ile Glu His Ala 
145                 150                 155                 160 


Lys Lys Val Ser Gln Gln Val Ser Lys Val Leu Tyr Lys Gln Asn Trp 
                165                 170                 175     


Glu Asp Thr Lys Asp Lys Tyr Leu Leu Pro Pro Asp Ala Pro Glu Leu 
            180                 185                 190         


Val Gln Ala Val Lys Asn Thr Ala Met Phe Ser Lys Lys Leu Tyr Thr 
        195                 200                 205             


Glu Asp Trp Glu Ala Asp Lys Ser Leu Phe Tyr Pro Tyr Asn Asp Ser 
    210                 215                 220                 


Pro Glu Leu Arg Arg Val Ala Gln Ala Gln Lys Ala Leu Ser Asp Val 
225                 230                 235                 240 


Ala Tyr Lys Lys Gly Leu Ala Glu Gln Gln Ala Gln Phe Thr Pro Leu 
                245                 250                 255     


Ala Asp Pro Pro Asp Ile Glu Phe Ala Lys Lys Val Thr Asn Gln Val 
            260                 265                 270         


Ser Lys Gln Lys Tyr Lys Glu Asp Tyr Glu Asn Lys Ile Lys Gly Lys 
        275                 280                 285             


Trp Ser Glu Thr Pro Cys Phe Glu Val Ala Asn Ala Arg Met Asn Ala 
    290                 295                 300                 


Asp Asn Ile Ser Thr Arg Lys Tyr Gln Glu Asp Phe Glu Asn Met Lys 
305                 310                 315                 320 


Asp Gln Ile Tyr Phe Met Gln Thr Glu Thr Pro Glu Tyr Lys Met Asn 
                325                 330                 335     


Lys Lys Ala Gly Val Ala Ala Ser Lys Val Lys Tyr Lys Glu Asp Tyr 
            340                 345                 350         


Glu Lys Asn Lys Gly Lys Ala Asp Tyr Asn Val Leu Pro Ala Ser Glu 
        355                 360                 365             


Asn Pro Gln Leu Arg Gln Leu Lys Ala Ala Gly Asp Ala Leu Ser Asp 
    370                 375                 380                 


Lys Leu Tyr Lys Glu Asn Tyr Glu Lys Thr Lys Ala Lys Ser Ile Asn 
385                 390                 395                 400 


Tyr Cys Glu Thr Pro Lys Phe Lys Leu Asp Thr Val Leu Gln Asn Phe 
                405                 410                 415     


Ser Ser Asp Lys Lys Tyr Lys Asp Ser Tyr Leu Lys Asp Ile Leu Gly 
            420                 425                 430         


His Tyr Val Gly Ser Phe Glu Asp Pro Tyr His Ser His Cys Met Lys 
        435                 440                 445             


Val Thr Ala Gln Asn Ser Asp Lys Asn Tyr Lys Ala Glu Tyr Glu Glu 
    450                 455                 460                 


Asp Arg Gly Lys Gly Phe Phe Pro Gln Thr Ile Thr Gln Glu Tyr Glu 
465                 470                 475                 480 


Ala Ile Lys Lys Leu Asp Gln Cys Lys Asp His Thr Tyr Lys Val His 
                485                 490                 495     


Pro Asp Lys Thr Lys Phe Thr Gln Val Thr Asp Ser Pro Val Leu Leu 
            500                 505                 510         


Gln Ala Gln Val Asn Ser Lys Gln Leu Ser Asp Leu Asn Tyr Lys Ala 
        515                 520                 525             


Lys His Glu Ser Glu Lys Phe Lys Cys His Ile Pro Pro Asp Thr Pro 
    530                 535                 540                 


Ala Phe Ile Gln His Lys Val Asn Ala Tyr Asn Leu Ser Asp Asn Leu 
545                 550                 555                 560 


Tyr Lys Gln Asp Trp Glu Lys Ser Lys Ala Lys Lys Phe Asp Ile Lys 
                565                 570                 575     


Val Asp Ala Ile Pro Leu Leu Ala Ala Lys Ala Asn Thr Lys Asn Thr 
            580                 585                 590         


Ser Asp Val Met Tyr Lys Lys Asp Tyr Glu Lys Asn Lys Gly Lys Met 
        595                 600                 605             


Ile Gly Val Leu Ser Ile Asn Asp Asp Pro Lys Met Leu His Ser Leu 
    610                 615                 620                 


Lys Val Ala Lys Asn Gln Ser Asp Arg Leu Tyr Lys Glu Asn Tyr Glu 
625                 630                 635                 640 


Lys Thr Lys Ala Lys Ser Met Asn Tyr Cys Glu Thr Pro Lys Tyr Gln 
                645                 650                 655     


Leu Asp Thr Gln Leu Lys Asn Phe Ser Glu Ala Arg Tyr Lys Asp Leu 
            660                 665                 670         


Tyr Val Lys Asp Val Leu Gly His Tyr Val Gly Ser Met Glu Asp Pro 
        675                 680                 685             


Tyr His Thr His Cys Met Lys Val Ala Ala Gln Asn Ser Asp Lys Ser 
    690                 695                 700                 


Tyr Lys Ala Glu Tyr Glu Glu Asp Lys Gly Lys Cys Tyr Phe Pro Gln 
705                 710                 715                 720 


Thr Ile Thr Gln Glu Tyr Asp Ala Ile Lys Lys Leu Asp Gln Cys Lys 
                725                 730                 735     


Asp His Thr Tyr Lys Val His Pro Asp Lys Thr Lys Phe Thr Ala Val 
            740                 745                 750         


Thr Asp Ser Pro Val Leu Leu Gln Ala Gln Leu Asn Thr Lys Gln Leu 
        755                 760                 765             


Ser Asp Leu Asn Tyr Lys Ala Lys His Glu Gly Glu Arg Phe Lys Cys 
    770                 775                 780                 


His Ile Pro Ala Asp Ala Pro Gln Phe Ile Gln His Arg Val Asn Ala 
785                 790                 795                 800 


Tyr Asn Leu Ser Asp Asn Val Tyr Lys Gln Asp Trp Glu Lys Ser Lys 
                805                 810                 815     


Ala Lys Lys Phe Asp Ile Lys Val Asp Ala Ile Pro Leu Leu Ala Ala 
            820                 825                 830         


Lys Ala Asn Thr Lys Asn Thr Ser Asp Val Met Tyr Lys Lys Asp Tyr 
        835                 840                 845             


Glu Lys Ser Lys Gly Lys Met Ile Gly Ala Leu Ser Ile Asn Asp Asp 
    850                 855                 860                 


Pro Lys Met Leu His Ser Leu Lys Thr Ala Lys Asn Gln Ser Asp Arg 
865                 870                 875                 880 


Glu Tyr Arg Lys Asp Tyr Glu Lys Ser Lys Thr Ile Tyr Thr Ala Pro 
                885                 890                 895     


Leu Asp Met Leu Gln Val Thr Gln Ala Lys Lys Ser Gln Ala Ile Ala 
            900                 905                 910         


Ser Asp Val Asp Tyr Lys His Ile Leu His Ser Tyr Ser Tyr Pro Pro 
        915                 920                 925             


Asp Ser Ile Asn Val Asp Leu Ala Lys Lys Ala Tyr Ala Leu Gln Ser 
    930                 935                 940                 


Asp Val Glu Tyr Lys Ala Asp Tyr Asn Ser Trp Met Lys Gly Cys Gly 
945                 950                 955                 960 


Trp Val Pro Phe Gly Ser Leu Glu Met Glu Lys Ala Lys Arg Ala Ser 
                965                 970                 975     


Asp Ile Leu Asn Glu Lys Lys Tyr Arg Gln His Pro Asp Thr Leu Lys 
            980                 985                 990         


Phe Thr Ser Ile Glu Asp Ala Pro  Ile Thr Val Gln Ser  Lys Ile Asn 
        995                 1000                 1005             


Gln Ala  Gln Arg Ser Asp Ile  Ala Tyr Lys Ala Lys  Gly Glu Glu 
    1010                 1015                 1020             


Ile Ile  His Asn Tyr Asn Leu  Pro Pro Asp Leu Pro  Gln Phe Ile 
    1025                 1030                 1035             


Gln Ala  Lys Val Asn Ala Tyr  Asn Ile Ser Glu Asn  Met Tyr Lys 
    1040                 1045                 1050             


Ala Asp  Leu Lys Asp Leu Ser  Lys Lys Gly Tyr Asp  Leu Arg Thr 
    1055                 1060                 1065             


Asp Ala  Ile Pro Ile Arg Ala  Ala Lys Ala Ala Arg  Gln Ala Ala 
    1070                 1075                 1080             


Ser Asp  Val Gln Tyr Lys Lys  Asp Tyr Glu Lys Ala  Lys Gly Lys 
    1085                 1090                 1095             


Met Val  Gly Phe Gln Ser Leu  Gln Asp Asp Pro Lys  Leu Val His 
    1100                 1105                 1110             


Tyr Met  Asn Val Ala Lys Ile  Gln Ser Asp Arg Glu  Tyr Lys Lys 
    1115                 1120                 1125             


Asp Tyr  Glu Lys Thr Lys Ser  Lys Tyr Asn Thr Pro  His Asp Met 
    1130                 1135                 1140             


Phe Asn  Val Val Ala Ala Lys  Lys Ala Gln Asp Val  Val Ser Asn 
    1145                 1150                 1155             


Val Asn  Tyr Lys His Ser Leu  His His Tyr Thr Tyr  Leu Pro Asp 
    1160                 1165                 1170             


Ala Met  Asp Leu Glu Leu Ser  Lys Asn Met Met Gln  Ile Gln Ser 
    1175                 1180                 1185             


Asp Asn  Val Tyr Lys Glu Asp  Tyr Asn Asn Trp Met  Lys Gly Ile 
    1190                 1195                 1200             


Gly Trp  Ile Pro Ile Gly Ser  Leu Asp Val Glu Lys  Val Lys Lys 
    1205                 1210                 1215             


Ala Gly  Asp Ala Leu Asn Glu  Lys Lys Tyr Arg Gln  His Pro Asp 
    1220                 1225                 1230             


Thr Leu  Lys Phe Thr Ser Ile  Val Asp Ser Pro Val  Met Val Gln 
    1235                 1240                 1245             


Ala Lys  Gln Asn Thr Lys Gln  Val Ser Asp Ile Leu  Tyr Lys Ala 
    1250                 1255                 1260             


Lys Gly  Glu Asp Val Lys His  Lys Tyr Thr Met Ser  Pro Asp Leu 
    1265                 1270                 1275             


Pro Gln  Phe Leu Gln Ala Lys  Cys Asn Ala Tyr Ser  Ile Ser Asp 
    1280                 1285                 1290             


Val Cys  Tyr Lys Arg Asp Trp  His Asp Leu Ile Arg  Lys Gly Asn 
    1295                 1300                 1305             


Asn Val  Leu Gly Asp Ala Ile  Pro Ile Thr Ala Ala  Lys Ala Ser 
    1310                 1315                 1320             


Arg Asn  Ile Ala Ser Asp Tyr  Lys Tyr Lys Glu Ala  Tyr Glu Lys 
    1325                 1330                 1335             


Ser Lys  Gly Lys His Val Gly  Phe Arg Ser Leu Gln  Asp Asp Pro 
    1340                 1345                 1350             


Lys Leu  Val His Tyr Met Asn  Val Ala Lys Leu Gln  Ser Asp Arg 
    1355                 1360                 1365             


Glu Tyr  Lys Lys Asn Tyr Glu  Asn Thr Lys Thr Ser  Tyr His Thr 
    1370                 1375                 1380             


Pro Gly  Asp Met Val Thr Ile  Thr Ala Ala Lys Met  Ala Gln Asp 
    1385                 1390                 1395             


Val Ala  Thr Asn Val Asn Tyr  Lys Gln Pro Leu His  His Tyr Thr 
    1400                 1405                 1410             


Tyr Leu  Pro Asp Ala Met Ser  Leu Glu His Thr Arg  Asn Val Asn 
    1415                 1420                 1425             


Gln Ile  Gln Ser Asp Asn Val  Tyr Lys Asp Glu Tyr  Asn Ser Phe 
    1430                 1435                 1440             


Leu Lys  Gly Ile Gly Trp Ile  Pro Ile Gly Ser Leu  Glu Val Glu 
    1445                 1450                 1455             


Lys Val  Lys Lys Ala Gly Asp  Ala Leu Asn Glu Arg  Lys Tyr Arg 
    1460                 1465                 1470             


Gln His  Pro Asp Thr Val Lys  Phe Thr Ser Val Pro  Asp Ser Met 
    1475                 1480                 1485             


Gly Met  Met Leu Ala Gln His  Asn Thr Lys Gln Leu  Ser Asp Leu 
    1490                 1495                 1500             


Asn Tyr  Lys Val Glu Gly Glu  Lys Leu Lys His Lys  Tyr Thr Ile 
    1505                 1510                 1515             


Asp Pro  Glu Leu Pro Gln Phe  Ile Gln Ala Lys Val  Asn Ala Leu 
    1520                 1525                 1530             


Asn Met  Ser Asp Ala His Tyr  Lys Ala Asp Trp Lys  Lys Thr Ile 
    1535                 1540                 1545             


Arg Lys  Gly Tyr Asp Leu Arg  Pro Asp Ala Ile Pro  Ile Val Ala 
    1550                 1555                 1560             


Ala Lys  Ser Ser Arg Asn Ile  Ala Ser Asp Cys Lys  Tyr Lys Glu 
    1565                 1570                 1575             


Ala Tyr  Glu Lys Ala Lys Gly  Lys Gln Val Gly Phe  Leu Ser Leu 
    1580                 1585                 1590             


Gln Asp  Asp Pro Lys Leu Val  His Tyr Met Asn Val  Ala Lys Ile 
    1595                 1600                 1605             


Gln Ser  Asp Arg Glu Tyr Lys  Lys Gly Tyr Glu Ala  Ser Lys Thr 
    1610                 1615                 1620             


Lys Tyr  His Thr Pro Leu Asp  Met Val Ser Val Thr  Ala Ala Lys 
    1625                 1630                 1635             


Lys Ser  Gln Glu Val Ala Thr  Asn Ala Asn Tyr Arg  Gln Ser Tyr 
    1640                 1645                 1650             


His His  Tyr Thr Leu Leu Pro  Asp Ala Leu Asn Val  Glu His Ser 
    1655                 1660                 1665             


Arg Asn  Ala Met Gln Ile Gln  Ser Asp Asn Leu Tyr  Lys Ser Asp 
    1670                 1675                 1680             


Phe Thr  Asn Trp Met Lys Gly  Ile Gly Trp Val Pro  Ile Glu Ser 
    1685                 1690                 1695             


Leu Glu  Val Glu Lys Ala Lys  Lys Ala Gly Glu Ile  Leu Ser Glu 
    1700                 1705                 1710             


Lys Lys  Tyr Arg Gln His Pro  Glu Lys Leu Lys Phe  Thr Tyr Ala 
    1715                 1720                 1725             


Met Asp  Thr Met Glu Gln Ala  Leu Asn Lys Ser Asn  Lys Leu Asn 
    1730                 1735                 1740             


Met Asp  Lys Arg Leu Tyr Thr  Glu Lys Trp Asn Lys  Asp Lys Thr 
    1745                 1750                 1755             


Thr Ile  His Val Met Pro Asp  Thr Pro Asp Ile Leu  Leu Ser Arg 
    1760                 1765                 1770             


Val Asn  Gln Ile Thr Met Ser  Asp Lys Leu Tyr Lys  Ala Gly Trp 
    1775                 1780                 1785             


Glu Glu  Glu Lys Lys Lys Gly  Tyr Asp Leu Arg Pro  Asp Ala Ile 
    1790                 1795                 1800             


Ala Ile  Lys Ala Ala Arg Ala  Ser Arg Asp Ile Ala  Ser Asp Tyr 
    1805                 1810                 1815             


Lys Tyr  Lys Lys Ala Tyr Glu  Gln Ala Lys Gly Lys  His Ile Gly 
    1820                 1825                 1830             


Phe Arg  Ser Leu Glu Asp Asp  Pro Lys Leu Val His  Phe Met Gln 
    1835                 1840                 1845             


Val Ala  Lys Met Gln Ser Asp  Arg Glu Tyr Lys Lys  Gly Tyr Glu 
    1850                 1855                 1860             


Lys Ser  Lys Thr Ser Phe His  Thr Pro Val Asp Met  Leu Ser Val 
    1865                 1870                 1875             


Val Ala  Ala Lys Lys Ser Gln  Glu Val Ala Thr Asn  Ala Asn Tyr 
    1880                 1885                 1890             


Arg Asn  Val Ile His Thr Tyr  Asn Met Leu Pro Asp  Ala Met Ser 
    1895                 1900                 1905             


Phe Glu  Leu Ala Lys Asn Met  Met Gln Ile Gln Ser  Asp Asn Gln 
    1910                 1915                 1920             


Tyr Lys  Ala Asp Tyr Ala Asp  Phe Met Lys Gly Ile  Gly Trp Leu 
    1925                 1930                 1935             


Pro Leu  Gly Ser Leu Glu Ala  Glu Lys Asn Lys Lys  Ala Met Glu 
    1940                 1945                 1950             


Ile Ile  Ser Glu Lys Lys Tyr  Arg Gln His Pro Asp  Thr Leu Lys 
    1955                 1960                 1965             


Tyr Ser  Thr Leu Met Asp Ser  Met Asn Met Val Leu  Ala Gln Asn 
    1970                 1975                 1980             


Asn Ala  Lys Ile Met Asn Glu  His Leu Tyr Lys Gln  Ala Trp Glu 
    1985                 1990                 1995             


Ala Asp  Lys Thr Lys Val His  Ile Met Pro Asp Ile  Pro Gln Ile 
    2000                 2005                 2010             


Ile Leu  Ala Lys Ala Asn Ala  Ile Asn Ile Ser Asp  Lys Leu Tyr 
    2015                 2020                 2025             


Lys Leu  Ser Leu Glu Glu Ser  Lys Lys Lys Gly Tyr  Asp Leu Arg 
    2030                 2035                 2040             


Pro Asp  Ala Ile Pro Ile Lys  Ala Ala Lys Ala Ser  Arg Asp Ile 
    2045                 2050                 2055             


Ala Ser  Asp Tyr Lys Tyr Lys  Tyr Asn Tyr Glu Lys  Gly Lys Gly 
    2060                 2065                 2070             


Lys Met  Val Gly Phe Arg Ser  Leu Glu Asp Asp Pro  Lys Leu Val 
    2075                 2080                 2085             


His Ser  Met Gln Val Ala Lys  Met Gln Ser Asp Arg  Glu Tyr Lys 
    2090                 2095                 2100             


Lys Asn  Tyr Glu Asn Thr Lys  Thr Ser Tyr His Thr  Pro Ala Asp 
    2105                 2110                 2115             


Met Leu  Ser Val Thr Ala Ala  Lys Asp Ala Gln Ala  Asn Ile Thr 
    2120                 2125                 2130             


Asn Thr  Asn Tyr Lys His Leu  Ile His Lys Tyr Ile  Leu Leu Pro 
    2135                 2140                 2145             


Asp Ala  Met Asn Ile Glu Leu  Thr Arg Asn Met Asn  Arg Ile Gln 
    2150                 2155                 2160             


Ser Asp  Asn Glu Tyr Lys Gln  Asp Tyr Asn Glu Trp  Tyr Lys Gly 
    2165                 2170                 2175             


Leu Gly  Trp Ser Pro Ala Gly  Ser Leu Glu Val Glu  Lys Ala Lys 
    2180                 2185                 2190             


Lys Ala  Thr Glu Tyr Ala Ser  Asp Gln Lys Tyr Arg  Gln His Pro 
    2195                 2200                 2205             


Ser Asn  Phe Gln Phe Lys Lys  Leu Thr Asp Ser Met  Asp Met Val 
    2210                 2215                 2220             


Leu Ala  Lys Gln Asn Ala His  Thr Met Asn Lys His  Leu Tyr Thr 
    2225                 2230                 2235             


Ile Asp  Trp Asn Lys Asp Lys  Thr Lys Ile His Val  Met Pro Asp 
    2240                 2245                 2250             


Thr Pro  Asp Ile Leu Gln Ala  Lys Gln Asn Gln Thr  Leu Tyr Ser 
    2255                 2260                 2265             


Gln Lys  Leu Tyr Lys Leu Gly  Trp Glu Glu Ala Leu  Lys Lys Gly 
    2270                 2275                 2280             


Tyr Asp  Leu Pro Val Asp Ala  Ile Ser Val Gln Leu  Ala Lys Ala 
    2285                 2290                 2295             


Ser Arg  Asp Ile Ala Ser Asp  Tyr Lys Tyr Lys Gln  Gly Tyr Arg 
    2300                 2305                 2310             


Lys Gln  Leu Gly His His Val  Gly Phe Arg Ser Leu  Gln Asp Asp 
    2315                 2320                 2325             


Pro Lys  Leu Val Leu Ser Met  Asn Val Ala Lys Met  Gln Ser Glu 
    2330                 2335                 2340             


Arg Glu  Tyr Lys Lys Asp Phe  Glu Lys Trp Lys Thr  Lys Phe Ser 
    2345                 2350                 2355             


Ser Pro  Val Asp Met Leu Gly  Val Val Leu Ala Lys  Lys Cys Gln 
    2360                 2365                 2370             


Glu Leu  Val Ser Asp Val Asp  Tyr Lys Asn Tyr Leu  His Gln Trp 
    2375                 2380                 2385             


Thr Cys  Leu Pro Asp Gln Asn  Asp Val Val Gln Ala  Lys Lys Val 
    2390                 2395                 2400             


Tyr Glu  Leu Gln Ser Glu Asn  Leu Tyr Lys Ser Asp  Leu Glu Trp 
    2405                 2410                 2415             


Leu Arg  Gly Ile Gly Trp Ser  Pro Leu Gly Ser Leu  Glu Ala Glu 
    2420                 2425                 2430             


Lys Asn  Lys Arg Ala Ser Glu  Ile Ile Ser Glu Lys  Lys Tyr Arg 
    2435                 2440                 2445             


Gln Pro  Pro Asp Arg Asn Lys  Phe Thr Ser Ile Pro  Asp Ala Met 
    2450                 2455                 2460             


Asp Ile  Val Leu Ala Lys Thr  Asn Ala Lys Asn Arg  Ser Asp Arg 
    2465                 2470                 2475             


Leu Tyr  Arg Glu Ala Trp Asp  Lys Asp Lys Thr Gln  Ile His Ile 
    2480                 2485                 2490             


Met Pro  Asp Thr Pro Asp Ile  Val Leu Ala Lys Ala  Asn Leu Ile 
    2495                 2500                 2505             


Asn Thr  Ser Asp Lys Leu Tyr  Arg Met Gly Tyr Glu  Glu Leu Lys 
    2510                 2515                 2520             


Arg Lys  Gly Tyr Asp Leu Pro  Val Asp Ala Ile Pro  Ile Lys Ala 
    2525                 2530                 2535             


Ala Lys  Ala Ser Arg Glu Ile  Ala Ser Glu Tyr Lys  Tyr Lys Glu 
    2540                 2545                 2550             


Gly Phe  Arg Lys Gln Leu Gly  His His Ile Gly Ala  Arg Asn Ile 
    2555                 2560                 2565             


Glu Asp  Asp Pro Lys Met Met  Trp Ser Met His Val  Ala Lys Ile 
    2570                 2575                 2580             


Gln Ser  Asp Arg Glu Tyr Lys  Lys Asp Phe Glu Lys  Trp Lys Thr 
    2585                 2590                 2595             


Lys Phe  Ser Ser Pro Val Asp  Met Leu Gly Val Val  Leu Ala Tyr 
    2600                 2605                 2610             


Lys Cys  Gln Thr Leu Val Ser  Asp Val Asp Tyr Lys  Asn Tyr Leu 
    2615                 2620                 2625             


His Gln  Trp Thr Cys Leu Pro  Asp Gln Ser Asp Val  Ile His Ala 
    2630                 2635                 2640             


Arg Gln  Ala Tyr Asp Leu Gln  Ser Asp Asn Leu Tyr  Lys Ser Asp 
    2645                 2650                 2655             


Leu Gln  Trp Leu Lys Gly Ile  Gly Trp Met Thr Ser  Gly Ser Leu 
    2660                 2665                 2670             


Glu Asp  Glu Lys Asn Lys Arg  Ala Thr Gln Ile Leu  Ser Asp His 
    2675                 2680                 2685             


Val Tyr  Arg Gln His Pro Asp  Gln Phe Lys Phe Ser  Ser Leu Met 
    2690                 2695                 2700             


Asp Ser  Ile Pro Met Val Leu  Ala Lys Asn Asn Ala  Ile Thr Met 
    2705                 2710                 2715             


Asn His  Arg Leu Tyr Thr Glu  Ala Trp Asp Lys Asp  Lys Thr Thr 
    2720                 2725                 2730             


Val His  Ile Met Pro Asp Thr  Pro Glu Val Leu Leu  Ala Lys Gln 
    2735                 2740                 2745             


Asn Lys  Val Asn Tyr Ser Glu  Lys Leu Tyr Lys Leu  Gly Leu Glu 
    2750                 2755                 2760             


Glu Ala  Lys Arg Lys Gly Tyr  Asp Met Arg Val Asp  Ala Ile Pro 
    2765                 2770                 2775             


Ile Lys  Ala Ala Lys Ala Ser  Arg Asp Ile Ala Ser  Glu Phe Lys 
    2780                 2785                 2790             


Tyr Lys  Glu Gly Tyr Arg Lys  Gln Leu Gly His His  Ile Gly Ala 
    2795                 2800                 2805             


Arg Ala  Ile Arg Asp Asp Pro  Lys Met Met Trp Ser  Met His Val 
    2810                 2815                 2820             


Ala Lys  Ile Gln Ser Asp Arg  Glu Tyr Lys Lys Asp  Phe Glu Lys 
    2825                 2830                 2835             


Trp Lys  Thr Lys Phe Ser Ser  Pro Val Asp Met Leu  Gly Val Val 
    2840                 2845                 2850             


Leu Ala  Lys Lys Cys Gln Thr  Leu Val Ser Asp Val  Asp Tyr Lys 
    2855                 2860                 2865             


Asn Tyr  Leu His Gln Trp Thr  Cys Leu Pro Asp Gln  Ser Asp Val 
    2870                 2875                 2880             


Ile His  Ala Arg Gln Ala Tyr  Asp Leu Gln Ser Asp  Asn Met Tyr 
    2885                 2890                 2895             


Lys Ser  Asp Leu Gln Trp Met  Arg Gly Ile Gly Trp  Val Ser Ile 
    2900                 2905                 2910             


Gly Ser  Leu Asp Val Glu Lys  Cys Lys Arg Ala Thr  Glu Ile Leu 
    2915                 2920                 2925             


Ser Asp  Lys Ile Tyr Arg Gln  Pro Pro Asp Arg Phe  Lys Phe Thr 
    2930                 2935                 2940             


Ser Val  Thr Asp Ser Leu Glu  Gln Val Leu Ala Lys  Asn Asn Ala 
    2945                 2950                 2955             


Leu Asn  Met Asn Lys Arg Leu  Tyr Thr Glu Ala Trp  Asp Lys Asp 
    2960                 2965                 2970             


Lys Thr  Gln Ile His Ile Met  Pro Asp Thr Pro Glu  Ile Met Leu 
    2975                 2980                 2985             


Ala Arg  Gln Asn Lys Ile Asn  Tyr Ser Glu Thr Leu  Tyr Lys Leu 
    2990                 2995                 3000             


Ala Asn  Glu Glu Ala Lys Lys  Lys Gly Tyr Asp Leu  Arg Ser Asp 
    3005                 3010                 3015             


Ala Ile  Pro Ile Val Ala Ala  Lys Ala Ser Arg Asp  Val Ile Ser 
    3020                 3025                 3030             


Asp Tyr  Lys Tyr Lys Asp Gly  Tyr Arg Lys Gln Leu  Gly His His 
    3035                 3040                 3045             


Ile Gly  Ala Arg Asn Ile Glu  Asp Asp Pro Lys Met  Met Trp Ser 
    3050                 3055                 3060             


Met His  Val Ala Lys Ile Gln  Ser Asp Arg Glu Tyr  Lys Lys Asp 
    3065                 3070                 3075             


Phe Glu  Lys Trp Lys Thr Lys  Phe Ser Ser Pro Val  Asp Met Leu 
    3080                 3085                 3090             


Gly Val  Val Leu Ala Lys Lys  Cys Gln Thr Leu Val  Ser Asp Val 
    3095                 3100                 3105             


Asp Tyr  Lys Asn Tyr Leu His  Glu Trp Thr Cys Leu  Pro Asp Gln 
    3110                 3115                 3120             


Asn Asp  Val Ile His Ala Arg  Gln Ala Tyr Asp Leu  Gln Ser Asp 
    3125                 3130                 3135             


Asn Ile  Tyr Lys Ser Asp Leu  Gln Trp Leu Arg Gly  Ile Gly Trp 
    3140                 3145                 3150             


Val Pro  Ile Gly Ser Met Asp  Val Val Lys Cys Lys  Arg Ala Ala 
    3155                 3160                 3165             


Glu Ile  Leu Ser Asp Asn Ile  Tyr Arg Gln Pro Pro  Asp Lys Leu 
    3170                 3175                 3180             


Lys Phe  Thr Ser Val Thr Asp  Ser Leu Glu Gln Val  Leu Ala Lys 
    3185                 3190                 3195             


Asn Asn  Ala Leu Asn Met Asn  Lys Arg Leu Tyr Thr  Glu Ala Trp 
    3200                 3205                 3210             


Asp Lys  Asp Lys Thr Gln Val  His Ile Met Pro Asp  Thr Pro Glu 
    3215                 3220                 3225             


Ile Met  Leu Ala Arg Gln Asn  Lys Ile Asn Tyr Ser  Glu Ser Leu 
    3230                 3235                 3240             


Tyr Arg  Gln Ala Met Glu Glu  Ala Lys Lys Glu Gly  Tyr Asp Leu 
    3245                 3250                 3255             


Arg Ser  Asp Ala Ile Pro Ile  Val Ala Ala Lys Ala  Ser Arg Asp 
    3260                 3265                 3270             


Ile Ala  Ser Asp Tyr Lys Tyr  Lys Glu Ala Tyr Arg  Lys Gln Leu 
    3275                 3280                 3285             


Gly His  His Ile Gly Ala Arg  Ala Val His Asp Asp  Pro Lys Ile 
    3290                 3295                 3300             


Met Trp  Ser Leu His Ile Ala  Lys Val Gln Ser Asp  Arg Glu Tyr 
    3305                 3310                 3315             


Lys Lys  Asp Phe Glu Lys Tyr  Lys Thr Arg Tyr Ser  Ser Pro Val 
    3320                 3325                 3330             


Asp Met  Leu Gly Ile Val Leu  Ala Lys Lys Cys Gln  Thr Leu Val 
    3335                 3340                 3345             


Ser Asp  Val Asp Tyr Lys His  Pro Leu His Glu Cys  Ile Cys Leu 
    3350                 3355                 3360             


Pro Asp  Gln Asn Asp Ile Ile  His Ala Arg Lys Ala  Tyr Asp Leu 
    3365                 3370                 3375             


Gln Ser  Asp Asn Leu Tyr Lys  Ser Asp Leu Glu Trp  Met Lys Gly 
    3380                 3385                 3390             


Ile Gly  Trp Val Pro Ile Asp  Ser Leu Glu Val Val  Arg Ala Lys 
    3395                 3400                 3405             


Arg Ala  Gly Glu Leu Leu Ser  Asp Thr Ile Tyr Arg  Gln Arg Pro 
    3410                 3415                 3420             


Glu Thr  Leu Lys Phe Thr Ser  Ile Thr Asp Thr Pro  Glu Gln Val 
    3425                 3430                 3435             


Leu Ala  Lys Asn Asn Ala Leu  Asn Met Asn Lys Arg  Leu Tyr Thr 
    3440                 3445                 3450             


Glu Ala  Trp Asp Asn Asp Lys  Lys Thr Ile His Val  Met Pro Asp 
    3455                 3460                 3465             


Thr Pro  Glu Ile Met Leu Ala  Lys Leu Asn Arg Ile  Asn Tyr Ser 
    3470                 3475                 3480             


Asp Lys  Leu Tyr Lys Leu Ala  Leu Glu Glu Ser Lys  Lys Glu Gly 
    3485                 3490                 3495             


Tyr Asp  Leu Arg Leu Asp Ala  Ile Pro Ile Gln Ala  Ala Lys Ala 
    3500                 3505                 3510             


Ser Arg  Asp Ile Ala Ser Asp  Tyr Lys Tyr Lys Glu  Gly Tyr Arg 
    3515                 3520                 3525             


Lys Gln  Leu Gly His His Ile  Gly Ala Arg Asn Ile  Lys Asp Asp 
    3530                 3535                 3540             


Pro Lys  Met Met Trp Ser Ile  His Val Ala Lys Ile  Gln Ser Asp 
    3545                 3550                 3555             


Arg Glu  Tyr Lys Lys Glu Phe  Glu Lys Trp Lys Thr  Lys Phe Ser 
    3560                 3565                 3570             


Ser Pro  Val Asp Met Leu Gly  Val Val Leu Ala Lys  Lys Cys Gln 
    3575                 3580                 3585             


Ile Leu  Val Ser Asp Ile Asp  Tyr Lys His Pro Leu  His Glu Trp 
    3590                 3595                 3600             


Thr Cys  Leu Pro Asp Gln Asn  Asp Val Ile Gln Ala  Arg Lys Ala 
    3605                 3610                 3615             


Tyr Asp  Leu Gln Ser Asp Ala  Ile Tyr Lys Ser Asp  Leu Glu Trp 
    3620                 3625                 3630             


Leu Arg  Gly Ile Gly Trp Val  Pro Ile Gly Ser Val  Glu Val Glu 
    3635                 3640                 3645             


Lys Val  Lys Arg Ala Gly Glu  Ile Leu Ser Asp Arg  Lys Tyr Arg 
    3650                 3655                 3660             


Gln Pro  Ala Asp Gln Leu Lys  Phe Thr Cys Ile Thr  Asp Thr Pro 
    3665                 3670                 3675             


Glu Ile  Val Leu Ala Lys Asn  Asn Ala Leu Thr Met  Ser Lys His 
    3680                 3685                 3690             


Leu Tyr  Thr Glu Ala Trp Asp  Ala Asp Lys Thr Ser  Ile His Val 
    3695                 3700                 3705             


Met Pro  Asp Thr Pro Asp Ile  Leu Leu Ala Lys Ser  Asn Ser Ala 
    3710                 3715                 3720             


Asn Ile  Ser Gln Lys Leu Tyr  Thr Lys Gly Trp Asp  Glu Ser Lys 
    3725                 3730                 3735             


Met Lys  Asp Tyr Asp Leu Arg  Ala Asp Ala Ile Ser  Ile Lys Ser 
    3740                 3745                 3750             


Ala Lys  Ala Ser Arg Asp Ile  Ala Ser Asp Tyr Lys  Tyr Lys Glu 
    3755                 3760                 3765             


Ala Tyr  Glu Lys Gln Lys Gly  His His Ile Gly Ala  Gln Ser Ile 
    3770                 3775                 3780             


Glu Asp  Asp Pro Lys Ile Met  Cys Ala Ile His Ala  Glu Lys Ile 
    3785                 3790                 3795             


Gln Ser  Glu Arg Glu Tyr Lys  Lys Glu Phe Gln Lys  Trp Lys Thr 
    3800                 3805                 3810             


Lys Phe  Ser Ser Pro Val Asp  Met Leu Ser Ile Leu  Leu Ala Lys 
    3815                 3820                 3825             


Lys Cys  Gln Thr Leu Val Thr  Asp Ile Tyr Tyr Arg  Asn Tyr Leu 
    3830                 3835                 3840             


His Glu  Trp Thr Cys Met Pro  Asp Gln Asn Asp Ile  Ile Gln Ala 
    3845                 3850                 3855             


Lys Lys  Ala Tyr Asp Leu Gln  Ser Asp Ala Leu Tyr  Lys Ala Asp 
    3860                 3865                 3870             


Leu Glu  Trp Leu Arg Gly Ile  Gly Trp Met Pro Gln  Gly Ser Pro 
    3875                 3880                 3885             


Glu Val  Leu Arg Val Lys Asn  Ala Gln Asn Ile Phe  Cys Asp Ser 
    3890                 3895                 3900             


Val Tyr  Arg Thr Pro Val Val  Asn Leu Lys Tyr Thr  Ser Ile Val 
    3905                 3910                 3915             


Asp Thr  Pro Glu Val Val Leu  Ala Lys Ser Asn Ala  Glu Asn Ile 
    3920                 3925                 3930             


Ser Ile  Pro Lys Tyr Arg Glu  Val Trp Asp Lys Asp  Lys Thr Ser 
    3935                 3940                 3945             


Ile His  Ile Met Pro Asp Thr  Pro Glu Ile Asn Leu  Ala Arg Ala 
    3950                 3955                 3960             


Asn Ala  Leu Asn Val Ser Asn  Lys Leu Tyr Arg Glu  Gly Trp Asp 
    3965                 3970                 3975             


Glu Met  Lys Ala Gly Cys Asp  Val Arg Leu Asp Ala  Ile Pro Ile 
    3980                 3985                 3990             


Gln Ala  Ala Lys Ala Ser Arg  Glu Ile Ala Ser Asp  Tyr Lys Tyr 
    3995                 4000                 4005             


Lys Leu  Asp His Glu Lys Gln  Lys Gly His Tyr Val  Gly Thr Leu 
    4010                 4015                 4020             


Thr Ala  Arg Asp Asp Asn Lys  Ile Arg Trp Ala Leu  Ile Ala Asp 
    4025                 4030                 4035             


Lys Leu  Gln Asn Glu Arg Glu  Tyr Arg Leu Asp Trp  Ala Lys Trp 
    4040                 4045                 4050             


Lys Ala  Lys Ile Gln Ser Pro  Val Asp Met Leu Ser  Ile Leu His 
    4055                 4060                 4065             


Ser Lys  Asn Ser Gln Ala Leu  Val Ser Asp Met Asp  Tyr Arg Asn 
    4070                 4075                 4080             


Tyr Leu  His Gln Trp Thr Cys  Met Pro Asp Gln Asn  Asp Val Ile 
    4085                 4090                 4095             


Gln Ala  Lys Lys Ala Tyr Glu  Leu Gln Ser Asp Asn  Val Tyr Lys 
    4100                 4105                 4110             


Ala Asp  Leu Glu Trp Leu Arg  Gly Ile Gly Trp Met  Pro Asn Asp 
    4115                 4120                 4125             


Ser Val  Ser Val Asn His Ala  Lys His Ala Ala Asp  Ile Phe Ser 
    4130                 4135                 4140             


Glu Lys  Lys Tyr Arg Thr Lys  Ile Glu Thr Leu Asn  Phe Thr Pro 
    4145                 4150                 4155             


Val Asp  Asp Arg Val Asp Tyr  Val Thr Ala Lys Gln  Ser Gly Glu 
    4160                 4165                 4170             


Ile Leu  Asp Asp Ile Lys Tyr  Arg Lys Asp Trp Asn  Ala Thr Lys 
    4175                 4180                 4185             


Ser Lys  Tyr Thr Leu Thr Glu  Thr Pro Leu Leu His  Thr Ala Gln 
    4190                 4195                 4200             


Glu Ala  Ala Arg Ile Leu Asp  Gln Tyr Leu Tyr Lys  Glu Gly Trp 
    4205                 4210                 4215             


Glu Arg  Gln Lys Ala Thr Gly  Tyr Ile Leu Pro Pro  Asp Ala Val 
    4220                 4225                 4230             


Pro Phe  Val His Ala His His  Cys Asn Asp Val Gln  Ser Glu Leu 
    4235                 4240                 4245             


Lys Tyr  Lys Ala Glu His Val  Lys Gln Lys Gly His  Tyr Val Gly 
    4250                 4255                 4260             


Val Pro  Thr Met Arg Asp Asp  Pro Lys Leu Val Trp  Phe Glu His 
    4265                 4270                 4275             


Ala Gly  Gln Ile Gln Asn Glu  Arg Leu Tyr Lys Glu  Asp Tyr His 
    4280                 4285                 4290             


Lys Thr  Lys Ala Lys Ile Asn  Ile Pro Ala Asp Met  Val Ser Val 
    4295                 4300                 4305             


Leu Ala  Ala Lys Gln Gly Gln  Thr Leu Val Ser Asp  Ile Asp Tyr 
    4310                 4315                 4320             


Arg Asn  Tyr Leu His Gln Trp  Met Cys His Pro Asp  Gln Asn Asp 
    4325                 4330                 4335             


Val Ile  Gln Ala Arg Lys Ala  Tyr Asp Leu Gln Ser  Asp Asn Val 
    4340                 4345                 4350             


Tyr Arg  Ala Asp Leu Glu Trp  Leu Arg Gly Ile Gly  Trp Ile Pro 
    4355                 4360                 4365             


Leu Asp  Ser Val Asp His Val  Arg Val Thr Lys Asn  Gln Glu Met 
    4370                 4375                 4380             


Met Ser  Gln Ile Lys Tyr Lys  Lys Asn Ala Leu Glu  Asn Tyr Pro 
    4385                 4390                 4395             


Asn Phe  Thr Ser Val Val Asp  Pro Pro Glu Ile Val  Leu Ala Lys 
    4400                 4405                 4410             


Ile Asn  Ser Val Asn Gln Ser  Asp Val Lys Tyr Lys  Glu Thr Phe 
    4415                 4420                 4425             


Asn Lys  Ala Lys Gly Lys Tyr  Thr Phe Ser Pro Asp  Thr Pro His 
    4430                 4435                 4440             


Ile Ser  His Ser Lys Asp Met  Gly Lys Leu Tyr Ser  Thr Ile Leu 
    4445                 4450                 4455             


Tyr Lys  Gly Ala Trp Glu Gly  Thr Lys Ala Tyr Gly  Tyr Thr Leu 
    4460                 4465                 4470             


Asp Glu  Arg Tyr Ile Pro Ile  Val Gly Ala Lys His  Ala Asp Leu 
    4475                 4480                 4485             


Val Asn  Ser Glu Leu Lys Tyr  Lys Glu Thr Tyr Glu  Lys Gln Lys 
    4490                 4495                 4500             


Gly His  Tyr Leu Ala Gly Lys  Val Ile Gly Glu Phe  Pro Gly Val 
    4505                 4510                 4515             


Val His  Cys Leu Asp Phe Gln  Lys Met Arg Ser Ala  Leu Asn Tyr 
    4520                 4525                 4530             


Arg Lys  His Tyr Glu Asp Thr  Lys Ala Asn Val His  Ile Pro Asn 
    4535                 4540                 4545             


Asp Met  Met Asn His Val Leu  Ala Lys Arg Cys Gln  Tyr Ile Leu 
    4550                 4555                 4560             


Ser Asp  Leu Glu Tyr Arg His  Tyr Phe His Gln Trp  Thr Ser Leu 
    4565                 4570                 4575             


Leu Glu  Glu Pro Asn Val Ile  Arg Val Arg Asn Ala  Gln Glu Ile 
    4580                 4585                 4590             


Leu Ser  Asp Asn Val Tyr Lys  Asp Asp Leu Asn Trp  Leu Lys Gly 
    4595                 4600                 4605             


Ile Gly  Cys Tyr Val Trp Asp  Thr Pro Gln Ile Leu  His Ala Lys 
    4610                 4615                 4620             


Lys Ser  Tyr Asp Leu Gln Ser  Gln Leu Gln Tyr Thr  Ala Ala Gly 
    4625                 4630                 4635             


Lys Glu  Asn Leu Gln Asn Tyr  Asn Leu Val Thr Asp  Thr Pro Leu 
    4640                 4645                 4650             


Tyr Val  Thr Ala Val Gln Ser  Gly Ile Asn Ala Ser  Glu Val Lys 
    4655                 4660                 4665             


Tyr Lys  Glu Asn Tyr His Gln  Ile Lys Asp Lys Tyr  Thr Thr Val 
    4670                 4675                 4680             


Leu Glu  Thr Val Asp Tyr Asp  Arg Thr Arg Asn Leu  Lys Asn Leu 
    4685                 4690                 4695             


Tyr Ser  Ser Asn Leu Tyr Lys  Glu Ala Trp Asp Arg  Val Lys Ala 
    4700                 4705                 4710             


Thr Ser  Tyr Ile Leu Pro Ser  Ser Thr Leu Ser Leu  Thr His Ala 
    4715                 4720                 4725             


Lys Asn  Gln Lys His Leu Ala  Ser His Ile Lys Tyr  Arg Glu Glu 
    4730                 4735                 4740             


Tyr Glu  Lys Phe Lys Ala Leu  Tyr Thr Leu Pro Arg  Ser Val Asp 
    4745                 4750                 4755             


Asp Asp  Pro Asn Thr Ala Arg  Cys Leu Arg Val Gly  Lys Leu Asn 
    4760                 4765                 4770             


Ile Asp  Arg Leu Tyr Arg Ser  Val Tyr Glu Lys Asn  Lys Met Lys 
    4775                 4780                 4785             


Ile His  Ile Val Pro Asp Met  Val Glu Met Val Thr  Ala Lys Asp 
    4790                 4795                 4800             


Ser Gln  Lys Lys Val Ser Glu  Ile Asp Tyr Arg Leu  Arg Leu His 
    4805                 4810                 4815             


Glu Trp  Ile Cys His Pro Asp  Leu Gln Val Asn Asp  His Val Arg 
    4820                 4825                 4830             


Lys Val  Thr Asp Gln Ile Ser  Asp Ile Val Tyr Lys  Asp Asp Leu 
    4835                 4840                 4845             


Asn Trp  Leu Lys Gly Ile Gly  Cys Tyr Val Trp Asp  Thr Pro Glu 
    4850                 4855                 4860             


Ile Leu  His Ala Lys His Ala  Tyr Asp Leu Arg Asp  Asp Ile Lys 
    4865                 4870                 4875             


Tyr Lys  Ala His Met Leu Lys  Thr Arg Asn Asp Tyr  Lys Leu Val 
    4880                 4885                 4890             


Thr Asp  Thr Pro Val Tyr Val  Gln Ala Val Lys Ser  Gly Lys Gln 
    4895                 4900                 4905             


Leu Ser  Asp Ala Val Tyr His  Tyr Asp Tyr Val His  Ser Val Arg 
    4910                 4915                 4920             


Gly Lys  Val Ala Pro Thr Thr  Lys Thr Val Asp Leu  Asp Arg Ala 
    4925                 4930                 4935             


Leu His  Ala Tyr Lys Leu Gln  Ser Ser Asn Leu Tyr  Lys Thr Ser 
    4940                 4945                 4950             


Leu Arg  Thr Leu Pro Thr Gly  Tyr Arg Leu Pro Gly  Asp Thr Pro 
    4955                 4960                 4965             


His Phe  Lys His Ile Lys Asp  Thr Arg Tyr Met Ser  Ser Tyr Phe 
    4970                 4975                 4980             


Lys Tyr  Lys Glu Ala Tyr Glu  His Thr Lys Ala Tyr  Gly Tyr Thr 
    4985                 4990                 4995             


Leu Gly  Pro Lys Asp Val Pro  Phe Val His Val Arg  Arg Val Asn 
    5000                 5005                 5010             


Asn Val  Thr Ser Glu Arg Leu  Tyr Arg Glu Leu Tyr  His Lys Leu 
    5015                 5020                 5025             


Lys Asp  Lys Ile His Thr Thr  Pro Asp Pro Pro Glu  Ile Arg Gln 
    5030                 5035                 5040             


Val Lys  Lys Thr Gln Glu Ala  Val Ser Glu Leu Ile  Tyr Lys Ser 
    5045                 5050                 5055             


Asp Phe  Phe Lys Met Gln Gly  His Met Ile Ser Leu  Pro Tyr Thr 
    5060                 5065                 5070             


Pro Gln  Val Ile His Cys Arg  Tyr Val Gly Asp Ile  Thr Ser Asp 
    5075                 5080                 5085             


Ile Lys  Tyr Lys Glu Asp Leu  Gln Val Leu Lys Gly  Phe Gly Cys 
    5090                 5095                 5100             


Phe Leu  Tyr Asp Thr Pro Asp  Met Val Arg Ser Arg  His Leu Arg 
    5105                 5110                 5115             


Lys Leu  Trp Ser Asn Tyr Leu  Tyr Thr Asp Lys Ala  Arg Glu Met 
    5120                 5125                 5130             


Arg Asp  Lys Tyr Lys Val Val  Leu Asp Thr Pro Glu  Tyr Arg Lys 
    5135                 5140                 5145             


Val Gln  Glu Leu Lys Thr His  Leu Ser Glu Leu Val  Tyr Arg Ala 
    5150                 5155                 5160             


Ala Gly  Lys Lys Gln Lys Ser  Ile Phe Thr Ser Val  Pro Asp Thr 
    5165                 5170                 5175             


Pro Asp  Leu Leu Arg Ala Lys  Arg Gly Gln Lys Leu  Gln Ser Gln 
    5180                 5185                 5190             


Tyr Leu  Tyr Val Glu Leu Ala  Thr Lys Glu Arg Pro  His His His 
    5195                 5200                 5205             


Ala Gly  Asn Gln Thr Thr Ala  Leu Lys His Ala Lys  Asp Val Lys 
    5210                 5215                 5220             


Asp Met  Val Ser Glu Lys Lys  Tyr Lys Ile Gln Tyr  Glu Lys Met 
    5225                 5230                 5235             


Lys Asp  Lys Tyr Thr Pro Val  Pro Asp Thr Pro Ile  Leu Ile Arg 
    5240                 5245                 5250             


Ala Lys  Arg Ala Tyr Trp Asn  Ala Ser Asp Leu Arg  Tyr Lys Glu 
    5255                 5260                 5265             


Thr Phe  Gln Lys Thr Lys Gly  Lys Tyr His Thr Val  Lys Asp Ala 
    5270                 5275                 5280             


Leu Asp  Ile Val Tyr His Arg  Lys Val Thr Asp Asp  Ile Ser Lys 
    5285                 5290                 5295             


Ile Lys  Tyr Lys Glu Asn Tyr  Met Ser Gln Leu Gly  Ile Trp Arg 
    5300                 5305                 5310             


Ser Ile  Pro Asp Arg Pro Glu  His Phe His His Arg  Ala Val Thr 
    5315                 5320                 5325             


Asp Thr  Val Ser Asp Val Lys  Tyr Lys Glu Asp Leu  Thr Trp Leu 
    5330                 5335                 5340             


Lys Gly  Ile Gly Cys Tyr Ala  Tyr Asp Thr Pro Asp  Phe Thr Leu 
    5345                 5350                 5355             


Ala Glu  Lys Asn Lys Thr Leu  Tyr Ser Lys Tyr Lys  Tyr Lys Glu 
    5360                 5365                 5370             


Val Phe  Glu Arg Thr Lys Ser  Asp Phe Lys Tyr Val  Ala Asp Ser 
    5375                 5380                 5385             


Pro Ile  Asn Arg His Phe Lys  Tyr Ala Thr Gln Leu  Met Asn Glu 
    5390                 5395                 5400             


Lys Lys  Tyr Arg Ala Asp Tyr  Glu Gln Arg Lys Asp  Lys Tyr His 
    5405                 5410                 5415             


Leu Val  Val Asp Glu Pro Arg  His Leu Leu Ala Lys  Thr Arg Ser 
    5420                 5425                 5430             


Asp Gln  Ile Ser Gln Ile Lys  Tyr Arg Lys Asn Tyr  Glu Lys Ser 
    5435                 5440                 5445             


Lys Asp  Lys Phe Thr Ser Ile  Val Asp Thr Pro Glu  His Leu Arg 
    5450                 5455                 5460             


Thr Thr  Lys Val Asn Lys Gln  Ile Ser Asp Ile Leu  Tyr Lys Leu 
    5465                 5470                 5475             


Glu Tyr  Asn Lys Ala Lys Pro  Arg Gly Tyr Thr Thr  Ile His Asp 
    5480                 5485                 5490             


Thr Pro  Met Leu Leu His Val  Arg Lys Val Lys Asp  Glu Val Ser 
    5495                 5500                 5505             


Asp Leu  Lys Tyr Lys Glu Val  Tyr Gln Arg Asn Lys  Ser Asn Cys 
    5510                 5515                 5520             


Thr Ile  Glu Pro Asp Ala Val  His Ile Lys Ala Ala  Lys Asp Ala 
    5525                 5530                 5535             


Tyr Lys  Val Asn Thr Asn Leu  Asp Tyr Lys Lys Gln  Tyr Glu Ala 
    5540                 5545                 5550             


Asn Lys  Ala His Trp Lys Trp  Thr Pro Asp Arg Pro  Asp Phe Leu 
    5555                 5560                 5565             


Gln Ala  Ala Lys Ser Ser Leu  Gln Gln Ser Asp Phe  Glu Tyr Lys 
    5570                 5575                 5580             


Leu Asp  Arg Glu Phe Leu Lys  Gly Cys Lys Leu Ser  Val Thr Asp 
    5585                 5590                 5595             


Asp Lys  Asn Thr Val Leu Ala  Leu Arg Asn Thr Leu  Ile Glu Ser 
    5600                 5605                 5610             


Asp Leu  Lys Tyr Lys Glu Lys  His Val Lys Glu Arg  Gly Thr Cys 
    5615                 5620                 5625             


His Ala  Val Pro Asp Thr Pro  Gln Ile Leu Leu Ala  Lys Thr Val 
    5630                 5635                 5640             


Ser Asn  Leu Val Ser Glu Asn  Lys Tyr Lys Asp His  Val Lys Lys 
    5645                 5650                 5655             


His Leu  Ala Gln Gly Ser Tyr  Thr Thr Leu Pro Glu  Thr Arg Asp 
    5660                 5665                 5670             


Thr Val  His Val Lys Glu Val  Thr Lys His Val Ser  Asp Thr Asn 
    5675                 5680                 5685             


Tyr Lys  Lys Lys Phe Val Lys  Glu Lys Gly Lys Ser  Asn Tyr Ser 
    5690                 5695                 5700             


Ile Met  Leu Glu Pro Pro Glu  Val Lys His Ala Met  Glu Val Ala 
    5705                 5710                 5715             


Lys Lys  Gln Ser Asp Val Ala  Tyr Arg Lys Asp Ala  Lys Glu Asn 
    5720                 5725                 5730             


Leu His  Tyr Thr Thr Val Ala  Asp Arg Pro Asp Ile  Lys Lys Ala 
    5735                 5740                 5745             


Thr Gln  Ala Ala Lys Gln Ala  Ser Glu Val Glu Tyr  Arg Ala Lys 
    5750                 5755                 5760             


His Arg  Lys Glu Gly Ser His  Gly Leu Ser Met Leu  Gly Arg Pro 
    5765                 5770                 5775             


Asp Ile  Glu Met Ala Lys Lys  Ala Ala Lys Leu Ser  Ser Gln Val 
    5780                 5785                 5790             


Lys Tyr  Arg Glu Asn Phe Asp  Lys Glu Lys Gly Lys  Thr Pro Lys 
    5795                 5800                 5805             


Tyr Asn  Pro Lys Asp Ser Gln  Leu Tyr Lys Val Met  Lys Asp Ala 
    5810                 5815                 5820             


Asn Asn  Leu Ala Ser Glu Val  Lys Tyr Lys Ala Asp  Leu Lys Lys 
    5825                 5830                 5835             


Leu His  Lys Pro Val Thr Asp  Met Lys Glu Ser Leu  Ile Met Asn 
    5840                 5845                 5850             


His Val  Leu Asn Thr Ser Gln  Leu Ala Ser Ser Tyr  Gln Tyr Lys 
    5855                 5860                 5865             


Lys Lys  Tyr Glu Lys Ser Lys  Gly His Tyr His Thr  Ile Pro Asp 
    5870                 5875                 5880             


Asn Leu  Glu Gln Leu His Leu  Lys Glu Ala Thr Glu  Leu Gln Ser 
    5885                 5890                 5895             


Ile Val  Lys Tyr Lys Glu Lys  Tyr Glu Lys Glu Arg  Gly Lys Pro 
    5900                 5905                 5910             


Met Leu  Asp Phe Glu Thr Pro  Thr Tyr Ile Thr Ala  Lys Glu Ser 
    5915                 5920                 5925             


Gln Gln  Met Gln Ser Gly Lys  Glu Tyr Arg Lys Asp  Tyr Glu Glu 
    5930                 5935                 5940             


Ser Ile  Lys Gly Arg Asn Leu  Thr Gly Leu Glu Val  Thr Pro Ala 
    5945                 5950                 5955             


Leu Leu  His Val Lys Tyr Ala  Thr Lys Ile Ala Ser  Glu Lys Glu 
    5960                 5965                 5970             


Tyr Arg  Lys Asp Leu Glu Glu  Ser Ile Arg Gly Lys  Gly Leu Thr 
    5975                 5980                 5985             


Glu Met  Glu Asp Thr Pro Asp  Met Leu Arg Ala Lys  Asn Ala Thr 
    5990                 5995                 6000             


Gln Ile  Leu Asn Glu Lys Glu  Tyr Lys Arg Asp Leu  Glu Leu Glu 
    6005                 6010                 6015             


Val Lys  Gly Arg Gly Leu Asn  Ala Met Ala Asn Glu  Thr Pro Asp 
    6020                 6025                 6030             


Phe Met  Arg Ala Arg Asn Ala  Thr Asp Ile Ala Ser  Gln Ile Lys 
    6035                 6040                 6045             


Tyr Lys  Gln Ser Ala Glu Met  Glu Lys Ala Asn Phe  Thr Ser Val 
    6050                 6055                 6060             


Val Asp  Thr Pro Glu Ile Ile  His Ala Gln Gln Val  Lys Asn Leu 
    6065                 6070                 6075             


Ser Ser  Gln Lys Lys Tyr Lys  Glu Asp Ala Glu Lys  Ser Met Ser 
    6080                 6085                 6090             


Tyr Tyr  Glu Thr Val Leu Asp  Thr Pro Glu Ile Gln  Arg Val Arg 
    6095                 6100                 6105             


Glu Asn  Gln Lys Asn Phe Ser  Leu Leu Gln Tyr Gln  Cys Asp Leu 
    6110                 6115                 6120             


Lys Asn  Ser Lys Gly Lys Ile  Thr Val Val Gln Asp  Thr Pro Glu 
    6125                 6130                 6135             


Ile Leu  Arg Val Lys Glu Asn  Gln Lys Asn Phe Ser  Ser Val Leu 
    6140                 6145                 6150             


Tyr Lys  Glu Asp Val Ser Pro  Gly Thr Ala Ile Gly  Lys Thr Pro 
    6155                 6160                 6165             


Glu Met  Met Arg Val Lys Gln  Thr Gln Asp His Ile  Ser Ser Val 
    6170                 6175                 6180             


Lys Tyr  Lys Glu Ala Ile Gly  Gln Gly Thr Pro Ile  Pro Asp Leu 
    6185                 6190                 6195             


Pro Glu  Val Lys Arg Val Lys  Glu Thr Gln Lys His  Ile Ser Ser 
    6200                 6205                 6210             


Val Met  Tyr Lys Glu Asn Leu  Gly Thr Gly Ile Pro  Thr Thr Val 
    6215                 6220                 6225             


Thr Pro  Glu Ile Glu Arg Val  Lys Arg Asn Gln Glu  Asn Phe Ser 
    6230                 6235                 6240             


Ser Val  Leu Tyr Lys Glu Asn  Leu Gly Lys Gly Ile  Pro Thr Pro 
    6245                 6250                 6255             


Ile Thr  Pro Glu Met Glu Arg  Val Lys Arg Asn Gln  Glu Asn Phe 
    6260                 6265                 6270             


Ser Ser  Val Leu Tyr Lys Glu  Asn Met Gly Lys Gly  Thr Pro Leu 
    6275                 6280                 6285             


Pro Val  Thr Pro Glu Met Glu  Arg Val Lys His Asn  Gln Glu Asn 
    6290                 6295                 6300             


Ile Ser  Ser Val Leu Tyr Lys  Glu Asn Val Gly Lys  Ala Thr Ala 
    6305                 6310                 6315             


Thr Pro  Val Thr Pro Glu Met  Gln Arg Val Lys Arg  Asn Gln Glu 
    6320                 6325                 6330             


Asn Ile  Ser Ser Val Leu Tyr  Lys Glu Asn Leu Gly  Lys Ala Thr 
    6335                 6340                 6345             


Pro Thr  Pro Phe Thr Pro Glu  Met Glu Arg Val Lys  Arg Asn Gln 
    6350                 6355                 6360             


Glu Asn  Phe Ser Ser Val Leu  Tyr Lys Glu Asn Met  Arg Lys Ala 
    6365                 6370                 6375             


Thr Pro  Thr Pro Val Thr Pro  Glu Met Glu Arg Ala  Lys Arg Asn 
    6380                 6385                 6390             


Gln Glu  Asn Ile Ser Ser Val  Leu Tyr Ser Asp Ser  Phe Arg Lys 
    6395                 6400                 6405             


Gln Ile  Gln Gly Lys Ala Ala  Tyr Val Leu Asp Thr  Pro Glu Met 
    6410                 6415                 6420             


Arg Arg  Val Arg Glu Thr Gln  Arg His Ile Ser Thr  Val Lys Tyr 
    6425                 6430                 6435             


His Glu  Asp Phe Glu Lys His  Lys Gly Cys Phe Thr  Pro Val Val 
    6440                 6445                 6450             


Thr Asp  Pro Ile Thr Glu Arg  Val Lys Lys Asn Met  Gln Asp Phe 
    6455                 6460                 6465             


Ser Asp  Ile Asn Tyr Arg Gly  Ile Gln Arg Lys Val  Val Glu Met 
    6470                 6475                 6480             


Glu Gln  Lys Arg Asn Asp Gln  Asp Gln Glu Thr Ile  Thr Gly Leu 
    6485                 6490                 6495             


Arg Val  Trp Arg Thr Asn Pro  Gly Ser Val Phe Asp  Tyr Asp Pro 
    6500                 6505                 6510             


Ala Glu  Asp Asn Ile Gln Ser  Arg Ser Leu His Met  Ile Asn Val 
    6515                 6520                 6525             


Gln Ala  Gln Arg Arg Ser Arg  Glu Gln Ser Arg Ser  Ala Ser Ala 
    6530                 6535                 6540             


Leu Ser  Val Ser Gly Gly Glu  Glu Lys Ser Glu His  Ser Glu Ala 
    6545                 6550                 6555             


Pro Asp  His His Leu Ser Thr  Tyr Ser Asp Gly Gly  Val Phe Ala 
    6560                 6565                 6570             


Val Ser  Thr Ala Tyr Lys His  Ala Lys Thr Thr Glu  Leu Pro Gln 
    6575                 6580                 6585             


Gln Arg  Ser Ser Ser Val Ala  Thr Gln Gln Thr Thr  Val Ser Ser 
    6590                 6595                 6600             


Ile Pro  Ser His Pro Ser Thr  Ala Gly Lys Ile Phe  Arg Ala Met 
    6605                 6610                 6615             


Tyr Asp  Tyr Met Ala Ala Asp  Ala Asp Glu Val Ser  Phe Lys Asp 
    6620                 6625                 6630             


Gly Asp  Ala Ile Ile Asn Val  Gln Ala Ile Asp Glu  Gly Trp Met 
    6635                 6640                 6645             


Tyr Gly  Thr Val Gln Arg Thr  Gly Arg Thr Gly Met  Leu Pro Ala 
    6650                 6655                 6660             


Asn Tyr  Val Glu Ala Ile 
    6665                 


<210>  631
<211>  2913
<212>  DNA
<213>  Homosapiens

<400>  631
cccgcccgcg tggtcgtcgc caccgcagcc gcccgagagg agctggggga ggacggtggc     60

ccgcgaggct cgtcgcagac aacgcggcgg cgatgtccgc gagccaggcg acacaaagtt    120

atcattgttg ggctggataa tgcagggaaa actaccattc tttaccaatt ttctatgaat    180

gaagttgtac atacatctcc tacaatagga agtaatgtag aagagatagt gattaataat    240

acacgtttcc taatgtggga tattggtggc caagaatctc ttcgttcttc ctggaacact    300

tactatacta acacagagtt tgtaatagtt gttgtggaca gtacagacag agagaggatt    360

tctgtaacta gagaagaact ctataaaatg ttagcgcatg aggacctaag aaaagctgga    420

ttgctgattt ttgctaataa acaagatgtt aaagaatgca tgactgtagc agaaatctcc    480

cagtttttga agctaacttc tattaaagat caccagtggc atatccaggc atgctgtgct    540

ctaactggcg agggattgtg ccaaggactt gaatggatga tgtcacgact taagattaga    600

tgatctctac tgacctcttc tcatagattt tgtataaatg aagtgctgga ctttacctga    660

aagctgcaaa aattaatggt ttagatatat ttataataaa ctgatttaaa ctttttctat    720

aagaagaaaa attaagacca cttatttgaa aacaaagatg aagtctcacc ttccagtttg    780

ctttctcatt agttttttcc aaagtaagtt attgaagctg tgattgacat ttttctcata    840

atgaatcctc tcaggacatt gtgtagccta tggtaagtac aaagggagag gaagacattt    900

tgaattttaa gagctttatt atcagtttaa ccctccctag ttgaatgtta ttttcttctt    960

gttccattaa gtcagaatac aaatcagcac agatattcga atgtttccaa tattttaaaa   1020

tgtaatgtta cttatgaaaa gtattttgct taaggttgtg tgtgtattgt gtatatacct   1080

caagttcaag ttaatggcat tgatttatgt tccagacaaa aataacacaa ataataatat   1140

ccttcgttat aaccacaatg agataagtat tggcattagt gttcagtgcc attttatact   1200

ttctctctgt gttctctgta ttgtactaac caacctccca aatcgctgag ctgcttgttt   1260

aaaaaaaaaa aaaaggaaaa ggaaaaagca tgacattgtg tatcgatttt ttgttgttga   1320

ccaaaatcac acacatggaa acatgtaatt caacagagtg ggaaagctag cagattcttg   1380

gcttagtatt actaataggc aggattgtac aatgagcaac tatcagatta ttcctttcag   1440

tggttcttat ggcatctaaa ttactgaata aattattaat ccattaatca gtgaatcaaa   1500

ttatgattac aattatcaaa tgaatgctca gcattaattg aaaactgttt tgtgaaacat   1560

gtctacccag aaaagtagca ttctataaat actattaaac aacttagcta tattattttt   1620

aagtattaaa ttatatgtca agcagttaaa gtgaatttca gagtaaaagt aaggcatgtt   1680

tctgagcaac attgataatt tcttaatttg caaatttctt cttattttgg tacttggaat   1740

atagtgtgag attttttatt tctaaatttt gttgtatctt ctattacata aatgcattga   1800

caattataaa atgcaagtgt tttttgaatg attttaagaa tttggcttaa aaattgattg   1860

atacaacgta ttatttgtac taagaagtaa cttgacccaa aacacctttt atgtttgctt   1920

agggtatatt ttttcagtgt ctgaaagtca aaggtattcc tgtcacaact gtaaacaaac   1980

ttatcctaaa tgtgttaaaa catattcttg ggtactctat ttatgtatct ttcatgcctt   2040

gaaaatctga aggttaatcc aaactcacat gttttagcat atttgagaaa aaaaaactac   2100

cttcaatatc agccttttaa atttcatgaa gattttggtg aggaataata gtatatagtt   2160

taagtattga caaaactttg aaagtttctt tctttaaaat gggaaatact caatatctaa   2220

atccaggtca ggcatgggat atcagtattt aacattggat gttttatgtt ttatatttat   2280

aatgttcaaa atgcaagcat aacatttaat atttgtccac atggttttac aaaagtaaat   2340

cttaaattac taagcttttc ccatatgttc tcgtactttc tcaaatccct ataaagaatt   2400

acttgttatc tattaaaaat ctcctttacc caaatctgta ttatggtttc gccagacaaa   2460

tattatgtga tgtagcccag aaaatccaca ccttttgtcc tttttatgtt ttaatttgaa   2520

taatcatgtg cttagtccct tggattactg ccacatcagt ttaacacgat atcagcacat   2580

tcccttgtca tcatcaaggt gttggctcag atttattctt aattggatgt ttaaagcatg   2640

tactaccttg ttacagttgg tttagtgtag tggattattg acatgacatc atgagaagat   2700

gtgtaatttt ataccacatt tataaaacat gattttgttt tctacccttc aaggtaaaca   2760

ttaaaaataa ggtggtactt gtgtacttgt acataaaacc aaaattatag ttgggaaaaa   2820

aataaattta tatatgaaaa tgtcaaaatc attttaaaag tattattttc aaataaaatg   2880

gagaagctgg tgaaaagtca tattggcaat ttt                                2913


<210>  632
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  632

Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Thr Asn Thr Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Thr Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp Val Lys Glu Cys Met 
                85                  90                  95      


Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu Thr Ser Ile Lys Asp 
            100                 105                 110         


His Gln Trp His Ile Gln Ala Cys Cys Ala Leu Thr Gly Glu Gly Leu 
        115                 120                 125             


Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu Lys Ile Arg 
    130                 135                 140         


<210>  633
<211>  3169
<212>  DNA
<213>  Homosapiens

<400>  633
cccgcccgcg tggtcgtcgc caccgcagcc gcccgagagg agctggggga ggacggtggc     60

ccgcgaggct cgtcgcagac aacgcggcgg cgatgtccgc gagccaggcg agtgccgcgg    120

cggcagcggc ggggccttgc gcgcggcagg gcggcctggg cttcggcctc cctccggttc    180

cctggaagcg ggcccgcgac cagcgcggga gcagcagcag aggcggaggc tccagcgcgt    240

ctctctcctc cccctcagcc tgagccgggg gaagccaggc ggcccgggtg tctggagggg    300

gggggtccgc tgcccgagaa tgggaattct cttcactaga atatggagac tgttcaatca    360

ccaggagcac aaagttatca ttgttgggct ggataatgca gggaaaacta ccattcttta    420

ccaattttct atgaatgaag ttgtacatac atctcctaca ataggaagta atgtagaaga    480

gatagtgatt aataatacac gtttcctaat gtgggatatt ggtggccaag aatctcttcg    540

ttcttcctgg aacacttact atactaacac agagtttgta atagttgttg tggacagtac    600

agacagagag aggatttctg taactagaga agaactctat aaaatgttag cgcatgagga    660

cctaagaaaa gctggattgc tgatttttgc taataaacaa gatgttaaag aatgcatgac    720

tgtagcagaa atctcccagt ttttgaagct aacttctatt aaagatcacc agtggcatat    780

ccaggcatgc tgtgctctaa ctggcgaggg attgtgccaa ggacttgaat ggatgatgtc    840

acgacttaag attagatgat ctctactgac ctcttctcat agattttgta taaatgaagt    900

gctggacttt acctgaaagc tgcaaaaatt aatggtttag atatatttat aataaactga    960

tttaaacttt ttctataaga agaaaaatta agaccactta tttgaaaaca aagatgaagt   1020

ctcaccttcc agtttgcttt ctcattagtt ttttccaaag taagttattg aagctgtgat   1080

tgacattttt ctcataatga atcctctcag gacattgtgt agcctatggt aagtacaaag   1140

ggagaggaag acattttgaa ttttaagagc tttattatca gtttaaccct ccctagttga   1200

atgttatttt cttcttgttc cattaagtca gaatacaaat cagcacagat attcgaatgt   1260

ttccaatatt ttaaaatgta atgttactta tgaaaagtat tttgcttaag gttgtgtgtg   1320

tattgtgtat atacctcaag ttcaagttaa tggcattgat ttatgttcca gacaaaaata   1380

acacaaataa taatatcctt cgttataacc acaatgagat aagtattggc attagtgttc   1440

agtgccattt tatactttct ctctgtgttc tctgtattgt actaaccaac ctcccaaatc   1500

gctgagctgc ttgtttaaaa aaaaaaaaaa ggaaaaggaa aaagcatgac attgtgtatc   1560

gattttttgt tgttgaccaa aatcacacac atggaaacat gtaattcaac agagtgggaa   1620

agctagcaga ttcttggctt agtattacta ataggcagga ttgtacaatg agcaactatc   1680

agattattcc tttcagtggt tcttatggca tctaaattac tgaataaatt attaatccat   1740

taatcagtga atcaaattat gattacaatt atcaaatgaa tgctcagcat taattgaaaa   1800

ctgttttgtg aaacatgtct acccagaaaa gtagcattct ataaatacta ttaaacaact   1860

tagctatatt atttttaagt attaaattat atgtcaagca gttaaagtga atttcagagt   1920

aaaagtaagg catgtttctg agcaacattg ataatttctt aatttgcaaa tttcttctta   1980

ttttggtact tggaatatag tgtgagattt tttatttcta aattttgttg tatcttctat   2040

tacataaatg cattgacaat tataaaatgc aagtgttttt tgaatgattt taagaatttg   2100

gcttaaaaat tgattgatac aacgtattat ttgtactaag aagtaacttg acccaaaaca   2160

ccttttatgt ttgcttaggg tatatttttt cagtgtctga aagtcaaagg tattcctgtc   2220

acaactgtaa acaaacttat cctaaatgtg ttaaaacata ttcttgggta ctctatttat   2280

gtatctttca tgccttgaaa atctgaaggt taatccaaac tcacatgttt tagcatattt   2340

gagaaaaaaa aactaccttc aatatcagcc ttttaaattt catgaagatt ttggtgagga   2400

ataatagtat atagtttaag tattgacaaa actttgaaag tttctttctt taaaatggga   2460

aatactcaat atctaaatcc aggtcaggca tgggatatca gtatttaaca ttggatgttt   2520

tatgttttat atttataatg ttcaaaatgc aagcataaca tttaatattt gtccacatgg   2580

ttttacaaaa gtaaatctta aattactaag cttttcccat atgttctcgt actttctcaa   2640

atccctataa agaattactt gttatctatt aaaaatctcc tttacccaaa tctgtattat   2700

ggtttcgcca gacaaatatt atgtgatgta gcccagaaaa tccacacctt ttgtcctttt   2760

tatgttttaa tttgaataat catgtgctta gtcccttgga ttactgccac atcagtttaa   2820

cacgatatca gcacattccc ttgtcatcat caaggtgttg gctcagattt attcttaatt   2880

ggatgtttaa agcatgtact accttgttac agttggttta gtgtagtgga ttattgacat   2940

gacatcatga gaagatgtgt aattttatac cacatttata aaacatgatt ttgttttcta   3000

cccttcaagg taaacattaa aaataaggtg gtacttgtgt acttgtacat aaaaccaaaa   3060

ttatagttgg gaaaaaaata aatttatata tgaaaatgtc aaaatcattt taaaagtatt   3120

attttcaaat aaaatggaga agctggtgaa aagtcatatt ggcaatttt               3169


<210>  634
<211>  179
<212>  PRT
<213>  Homosapiens

<400>  634

Met Gly Ile Leu Phe Thr Arg Ile Trp Arg Leu Phe Asn His Gln Glu 
1               5                   10                  15      


His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile 
            20                  25                  30          


Leu Tyr Gln Phe Ser Met Asn Glu Val Val His Thr Ser Pro Thr Ile 
        35                  40                  45              


Gly Ser Asn Val Glu Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met 
    50                  55                  60                  


Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr 
65                  70                  75                  80  


Tyr Thr Asn Thr Glu Phe Val Ile Val Val Val Asp Ser Thr Asp Arg 
                85                  90                  95      


Glu Arg Ile Ser Val Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His 
            100                 105                 110         


Glu Asp Leu Arg Lys Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Val Lys Glu Cys Met Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu 
    130                 135                 140                 


Thr Ser Ile Lys Asp His Gln Trp His Ile Gln Ala Cys Cys Ala Leu 
145                 150                 155                 160 


Thr Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu 
                165                 170                 175     


Lys Ile Arg 
            


<210>  635
<211>  2911
<212>  DNA
<213>  Homosapiens

<400>  635
cccgcccgcg tggtcgtcgc caccgcagcc gcccgagagg agctggggga ggacggtggc     60

ccgcgaggct cgtcgcagac aacgcggcgg cgatgtccgc gagccagagc acaaagttat    120

cattgttggg ctggataatg cagggaaaac taccattctt taccaatttt ctatgaatga    180

agttgtacat acatctccta caataggaag taatgtagaa gagatagtga ttaataatac    240

acgtttccta atgtgggata ttggtggcca agaatctctt cgttcttcct ggaacactta    300

ctatactaac acagagtttg taatagttgt tgtggacagt acagacagag agaggatttc    360

tgtaactaga gaagaactct ataaaatgtt agcgcatgag gacctaagaa aagctggatt    420

gctgattttt gctaataaac aagatgttaa agaatgcatg actgtagcag aaatctccca    480

gtttttgaag ctaacttcta ttaaagatca ccagtggcat atccaggcat gctgtgctct    540

aactggcgag ggattgtgcc aaggacttga atggatgatg tcacgactta agattagatg    600

atctctactg acctcttctc atagattttg tataaatgaa gtgctggact ttacctgaaa    660

gctgcaaaaa ttaatggttt agatatattt ataataaact gatttaaact ttttctataa    720

gaagaaaaat taagaccact tatttgaaaa caaagatgaa gtctcacctt ccagtttgct    780

ttctcattag ttttttccaa agtaagttat tgaagctgtg attgacattt ttctcataat    840

gaatcctctc aggacattgt gtagcctatg gtaagtacaa agggagagga agacattttg    900

aattttaaga gctttattat cagtttaacc ctccctagtt gaatgttatt ttcttcttgt    960

tccattaagt cagaatacaa atcagcacag atattcgaat gtttccaata ttttaaaatg   1020

taatgttact tatgaaaagt attttgctta aggttgtgtg tgtattgtgt atatacctca   1080

agttcaagtt aatggcattg atttatgttc cagacaaaaa taacacaaat aataatatcc   1140

ttcgttataa ccacaatgag ataagtattg gcattagtgt tcagtgccat tttatacttt   1200

ctctctgtgt tctctgtatt gtactaacca acctcccaaa tcgctgagct gcttgtttaa   1260

aaaaaaaaaa aaggaaaagg aaaaagcatg acattgtgta tcgatttttt gttgttgacc   1320

aaaatcacac acatggaaac atgtaattca acagagtggg aaagctagca gattcttggc   1380

ttagtattac taataggcag gattgtacaa tgagcaacta tcagattatt cctttcagtg   1440

gttcttatgg catctaaatt actgaataaa ttattaatcc attaatcagt gaatcaaatt   1500

atgattacaa ttatcaaatg aatgctcagc attaattgaa aactgttttg tgaaacatgt   1560

ctacccagaa aagtagcatt ctataaatac tattaaacaa cttagctata ttatttttaa   1620

gtattaaatt atatgtcaag cagttaaagt gaatttcaga gtaaaagtaa ggcatgtttc   1680

tgagcaacat tgataatttc ttaatttgca aatttcttct tattttggta cttggaatat   1740

agtgtgagat tttttatttc taaattttgt tgtatcttct attacataaa tgcattgaca   1800

attataaaat gcaagtgttt tttgaatgat tttaagaatt tggcttaaaa attgattgat   1860

acaacgtatt atttgtacta agaagtaact tgacccaaaa caccttttat gtttgcttag   1920

ggtatatttt ttcagtgtct gaaagtcaaa ggtattcctg tcacaactgt aaacaaactt   1980

atcctaaatg tgttaaaaca tattcttggg tactctattt atgtatcttt catgccttga   2040

aaatctgaag gttaatccaa actcacatgt tttagcatat ttgagaaaaa aaaactacct   2100

tcaatatcag ccttttaaat ttcatgaaga ttttggtgag gaataatagt atatagttta   2160

agtattgaca aaactttgaa agtttctttc tttaaaatgg gaaatactca atatctaaat   2220

ccaggtcagg catgggatat cagtatttaa cattggatgt tttatgtttt atatttataa   2280

tgttcaaaat gcaagcataa catttaatat ttgtccacat ggttttacaa aagtaaatct   2340

taaattacta agcttttccc atatgttctc gtactttctc aaatccctat aaagaattac   2400

ttgttatcta ttaaaaatct cctttaccca aatctgtatt atggtttcgc cagacaaata   2460

ttatgtgatg tagcccagaa aatccacacc ttttgtcctt tttatgtttt aatttgaata   2520

atcatgtgct tagtcccttg gattactgcc acatcagttt aacacgatat cagcacattc   2580

ccttgtcatc atcaaggtgt tggctcagat ttattcttaa ttggatgttt aaagcatgta   2640

ctaccttgtt acagttggtt tagtgtagtg gattattgac atgacatcat gagaagatgt   2700

gtaattttat accacattta taaaacatga ttttgttttc tacccttcaa ggtaaacatt   2760

aaaaataagg tggtacttgt gtacttgtac ataaaaccaa aattatagtt gggaaaaaaa   2820

taaatttata tatgaaaatg tcaaaatcat tttaaaagta ttattttcaa ataaaatgga   2880

gaagctggtg aaaagtcata ttggcaattt t                                  2911


<210>  636
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  636

Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Thr Asn Thr Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Thr Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp Val Lys Glu Cys Met 
                85                  90                  95      


Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu Thr Ser Ile Lys Asp 
            100                 105                 110         


His Gln Trp His Ile Gln Ala Cys Cys Ala Leu Thr Gly Glu Gly Leu 
        115                 120                 125             


Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu Lys Ile Arg 
    130                 135                 140         


<210>  637
<211>  3079
<212>  DNA
<213>  Homosapiens

<400>  637
catgcggcgg ctctgaacga tgtcctcctc ctcctacgcc aagaacggga ccgcggacgg     60

gccgcactcc cccacctcgc aggtggcccg aggcaccaca acccggagga gcaggttgaa    120

aagatccgat ggcagcacca cttcgaccag cttcatcctc agacagggtt cagcggattc    180

ctacacaagc aggccgtctg actccgatgt ctctttggaa gaggaccggg aagcaattcg    240

acaggagaga gaacagcaag cagctatcca gcttgagaga gcaaagtcca aacctgtagc    300

atttgccgtg aagacaaatg tgagctactg cggcgccctg gacgaggatg tgcctgttcc    360

aagcacagct atctcctttg atgctaaaga ctttctacat attaaagaga aatataacaa    420

tgattggtgg ataggaaggc tggtgaaaga gggctgtgaa attggcttca ttccaagtcc    480

actcagattg gagaacatac ggatccagca agaacaaaaa agaggacgtt ttcacggagg    540

gaaatcaagt ggaaattctt cttcaagtct tggagaaatg gtatctggga cattccgagc    600

aactcccaca tcaacagcaa aacagaagca aaaagtgacg gagcacattc ctccttacga    660

tgttgtaccg tcaatgcgtc cggtggtgtt agtggggccg tcactgaaag gttacgaggt    720

aacagacatg atgcagaaag ccctctttga tttcctgaag cacaggtttg atgggaggat    780

ttcaataacg agagtgacag ctgacatttc tcttgctaag aggtctgtcc taaataatcc    840

cagcaagaga gcaataattg aacgttcgaa cacccggtcc agcttagcgg aagtacaaag    900

tgaaattgaa agaatctttg agttggcaag atctttgcaa ctggttgttc ttgatgcaga    960

caccatcaat cacccagcac aacttataaa gacttcctta gcaccaatta ttgttcatgt   1020

aaaagtctca tctccaaagg ttttacagcg gttgattaaa tctagaggaa agtcacaaag   1080

taaacacttg aatgttcaac tggtggcagc tgataaactt gcacaatgcc ccccagaaat   1140

gtttgatgtt atattggatg aaaatcagct tgaggatgca tgtgaacatc taggggagta   1200

cctggaggcg tactggcgtg ccacccacac aaccagtagc acacccatga ccccgctgct   1260

gggaaggaat ttgggctcca cggcactctc accatatccc acagcaattt ctgggttaca   1320

gagtcagcga atgaggcaca gcaaccactc cacagagaac tctccaattg aaagacgaag   1380

tctaatgacc tctgatgaaa attatcacaa tgaaagggct cggaagagta ggaaccgctt   1440

gtcttccagt tctcagcata gccgagatca ttaccctctt gtggaagaag attaccctga   1500

ctcataccag gacacttaca aaccccatag gaaccgagga tcacctgggg gatatagcca   1560

tgactcccga cataggcttt gagtctaatg aaacaaaaaa tattcatctg ttgacaattt   1620

gccatagcag tgctaggata aaccaatcat cttaacttgg ctaacatagc acagtattta   1680

ctgtgctaat gggctgctgt cattttatgc taagtaaggg gcaaaaaaaa aaattacatt   1740

atgcccttga gtctagatgg atattagatg cccgatcata tagatatttt taagtgcaac   1800

atttacatga taacagtaca ttttgttttc ttcatagatt tagacacatc aatttgtaat   1860

ttagggtact tacaaggcac atataaaata atttcccatg ctggaaattc caaatgacca   1920

gttccagttg gaaccaattt ataaaccaat tcctgttgga atttgggtga attgactaga   1980

aagtctactt gagcatgttg taatcaactg aaaaatctgg ggggaaaaaa aaaaaactaa   2040

taagaaaatc gaaataccaa tagaagccaa atccagcttt ggtatttatt tgctggaagc   2100

taaatttaca cttaaagttg gagtgtataa acattttaat atatgttaat gttgccagaa   2160

tgacttttca gacttaccaa atgtattgat agtgccaaaa aaaaaatctc agaaatctta   2220

atgcagaaat tatatagtct cctcagattt taatattttt atttctttcc tggcacagct   2280

gttgtattca aagtgttttg ctttttgttt ggtcagtact gttagctcat ttgaagttgg   2340

caaaaacaaa tacaaacaag caaaaaacct caaatttttt tcagcagtga gagagaatag   2400

taaagagagg cccaagcata gctggttatg tgaaatataa aatggggtgt tgttctccct   2460

ttaatcaatc tgagcacaac tacatacatc caggaatctg aagtcagata gtaaggatgt   2520

ggtaccaatc ctcccgagtg caatgctaaa cacttccagg tgggaattca tctatttcac   2580

ttaacacaaa cgcagggtct gtatttcctg ccaacaagat tgagtatctt tccattgctt   2640

ctctcagtct ctgtctttga atatctgaat gttctggccc ttcaacaaat tctttaaatc   2700

atgctaagga atttcgtttt atgtggacac actcaacttt gatattcagg agatgttttt   2760

acaaaatgac taattgaaaa aagttgaaac aaatgatttt aaaagcttgc agtaaaaaat   2820

aaactcatag attcagcaaa tatttgttga ctaaaattat agcattttta atgcagaaaa   2880

ttataaagaa tttggagatt gagctgcctt atttctaatg aacactcctc ttcatcttat   2940

taagtcttca cagtttttcc agtggctata attatggaat tggtgaccta tgttttatat   3000

tatcaaggaa gccttagatt cactctgatc taagaaatta ttgaaattga ccctttttac   3060

acaaatgtct ttaaaaaaa                                                3079


<210>  638
<211>  520
<212>  PRT
<213>  Homosapiens

<400>  638

Met Ser Ser Ser Ser Tyr Ala Lys Asn Gly Thr Ala Asp Gly Pro His 
1               5                   10                  15      


Ser Pro Thr Ser Gln Val Ala Arg Gly Thr Thr Thr Arg Arg Ser Arg 
            20                  25                  30          


Leu Lys Arg Ser Asp Gly Ser Thr Thr Ser Thr Ser Phe Ile Leu Arg 
        35                  40                  45              


Gln Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val 
    50                  55                  60                  


Ser Leu Glu Glu Asp Arg Glu Ala Ile Arg Gln Glu Arg Glu Gln Gln 
65                  70                  75                  80  


Ala Ala Ile Gln Leu Glu Arg Ala Lys Ser Lys Pro Val Ala Phe Ala 
                85                  90                  95      


Val Lys Thr Asn Val Ser Tyr Cys Gly Ala Leu Asp Glu Asp Val Pro 
            100                 105                 110         


Val Pro Ser Thr Ala Ile Ser Phe Asp Ala Lys Asp Phe Leu His Ile 
        115                 120                 125             


Lys Glu Lys Tyr Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu 
    130                 135                 140                 


Gly Cys Glu Ile Gly Phe Ile Pro Ser Pro Leu Arg Leu Glu Asn Ile 
145                 150                 155                 160 


Arg Ile Gln Gln Glu Gln Lys Arg Gly Arg Phe His Gly Gly Lys Ser 
                165                 170                 175     


Ser Gly Asn Ser Ser Ser Ser Leu Gly Glu Met Val Ser Gly Thr Phe 
            180                 185                 190         


Arg Ala Thr Pro Thr Ser Thr Ala Lys Gln Lys Gln Lys Val Thr Glu 
        195                 200                 205             


His Ile Pro Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu 
    210                 215                 220                 


Val Gly Pro Ser Leu Lys Gly Tyr Glu Val Thr Asp Met Met Gln Lys 
225                 230                 235                 240 


Ala Leu Phe Asp Phe Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile 
                245                 250                 255     


Thr Arg Val Thr Ala Asp Ile Ser Leu Ala Lys Arg Ser Val Leu Asn 
            260                 265                 270         


Asn Pro Ser Lys Arg Ala Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser 
        275                 280                 285             


Leu Ala Glu Val Gln Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg 
    290                 295                 300                 


Ser Leu Gln Leu Val Val Leu Asp Ala Asp Thr Ile Asn His Pro Ala 
305                 310                 315                 320 


Gln Leu Ile Lys Thr Ser Leu Ala Pro Ile Ile Val His Val Lys Val 
                325                 330                 335     


Ser Ser Pro Lys Val Leu Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser 
            340                 345                 350         


Gln Ser Lys His Leu Asn Val Gln Leu Val Ala Ala Asp Lys Leu Ala 
        355                 360                 365             


Gln Cys Pro Pro Glu Met Phe Asp Val Ile Leu Asp Glu Asn Gln Leu 
    370                 375                 380                 


Glu Asp Ala Cys Glu His Leu Gly Glu Tyr Leu Glu Ala Tyr Trp Arg 
385                 390                 395                 400 


Ala Thr His Thr Thr Ser Ser Thr Pro Met Thr Pro Leu Leu Gly Arg 
                405                 410                 415     


Asn Leu Gly Ser Thr Ala Leu Ser Pro Tyr Pro Thr Ala Ile Ser Gly 
            420                 425                 430         


Leu Gln Ser Gln Arg Met Arg His Ser Asn His Ser Thr Glu Asn Ser 
        435                 440                 445             


Pro Ile Glu Arg Arg Ser Leu Met Thr Ser Asp Glu Asn Tyr His Asn 
    450                 455                 460                 


Glu Arg Ala Arg Lys Ser Arg Asn Arg Leu Ser Ser Ser Ser Gln His 
465                 470                 475                 480 


Ser Arg Asp His Tyr Pro Leu Val Glu Glu Asp Tyr Pro Asp Ser Tyr 
                485                 490                 495     


Gln Asp Thr Tyr Lys Pro His Arg Asn Arg Gly Ser Pro Gly Gly Tyr 
            500                 505                 510         


Ser His Asp Ser Arg His Arg Leu 
        515                 520 


<210>  639
<211>  3062
<212>  DNA
<213>  Homosapiens

<400>  639
agcctccccc agcggatgcc ggggactcgg accccgcacc ctgagagtct ttgttaatgg     60

atgtggtggc ccgaggcacc acaacccgga ggagcaggtt gaaaagatcc gatggcagca    120

ccacttcgac cagcttcatc ctcagacagg gttcagcgga ttcctacaca agcaggccgt    180

ctgactccga tgtctctttg gaagaggacc gggaagcaat tcgacaggag agagaacagc    240

aagcagctat ccagcttgag agagcaaagt ccaaacctgt agcatttgcc gtgaagacaa    300

atgtgagcta ctgcggcgcc ctggacgagg atgtgcctgt tccaagcaca gctatctcct    360

ttgatgctaa agactttcta catattaaag agaaatataa caatgattgg tggataggaa    420

ggctggtgaa agagggctgt gaaattggct tcattccaag tccactcaga ttggagaaca    480

tacggatcca gcaagaacaa aaaagaggac gttttcacgg agggaaatca agtggaaatt    540

cttcttcaag tcttggagaa atggtatctg ggacattccg agcaactccc acatcaacag    600

caaaacagaa gcaaaaagtg acggagcaca ttcctcctta cgatgttgta ccgtcaatgc    660

gtccggtggt gttagtgggg ccgtcactga aaggttacga ggtaacagac atgatgcaga    720

aagccctctt tgatttcctg aagcacaggt ttgatgggag gatttcaata acgagagtga    780

cagctgacat ttctcttgct aagaggtctg tcctaaataa tcccagcaag agagcaataa    840

ttgaacgttc gaacacccgg tccagcttag cggaagtaca aagtgaaatt gaaagaatct    900

ttgagttggc aagatctttg caactggttg ttcttgatgc agacaccatc aatcacccag    960

cacaacttat aaagacttcc ttagcaccaa ttattgttca tgtaaaagtc tcatctccaa   1020

aggttttaca gcggttgatt aaatctagag gaaagtcaca aagtaaacac ttgaatgttc   1080

aactggtggc agctgataaa cttgcacaat gccccccaga aatgtttgat gttatattgg   1140

atgaaaatca gcttgaggat gcatgtgaac atctagggga gtacctggag gcgtactggc   1200

gtgccaccca cacaaccagt agcacaccca tgaccccgct gctgggaagg aatttgggct   1260

ccacggcact ctcaccatat cccacagcaa tttctgggtt acagagtcag cgaatgaggc   1320

acagcaacca ctccacagag aactctccaa ttgaaagacg aagtctaatg acctctgatg   1380

aaaattatca caatgaaagg gctcggaaga gtaggaaccg cttgtcttcc agttctcagc   1440

atagccgaga tcattaccct cttgtggaag aagattaccc tgactcatac caggacactt   1500

acaaacccca taggaaccga ggatcacctg ggggatatag ccatgactcc cgacataggc   1560

tttgagtcta atgaaacaaa aaatattcat ctgttgacaa tttgccatag cagtgctagg   1620

ataaaccaat catcttaact tggctaacat agcacagtat ttactgtgct aatgggctgc   1680

tgtcatttta tgctaagtaa ggggcaaaaa aaaaaattac attatgccct tgagtctaga   1740

tggatattag atgcccgatc atatagatat ttttaagtgc aacatttaca tgataacagt   1800

acattttgtt ttcttcatag atttagacac atcaatttgt aatttagggt acttacaagg   1860

cacatataaa ataatttccc atgctggaaa ttccaaatga ccagttccag ttggaaccaa   1920

tttataaacc aattcctgtt ggaatttggg tgaattgact agaaagtcta cttgagcatg   1980

ttgtaatcaa ctgaaaaatc tggggggaaa aaaaaaaaac taataagaaa atcgaaatac   2040

caatagaagc caaatccagc tttggtattt atttgctgga agctaaattt acacttaaag   2100

ttggagtgta taaacatttt aatatatgtt aatgttgcca gaatgacttt tcagacttac   2160

caaatgtatt gatagtgcca aaaaaaaaat ctcagaaatc ttaatgcaga aattatatag   2220

tctcctcaga ttttaatatt tttatttctt tcctggcaca gctgttgtat tcaaagtgtt   2280

ttgctttttg tttggtcagt actgttagct catttgaagt tggcaaaaac aaatacaaac   2340

aagcaaaaaa cctcaaattt ttttcagcag tgagagagaa tagtaaagag aggcccaagc   2400

atagctggtt atgtgaaata taaaatgggg tgttgttctc cctttaatca atctgagcac   2460

aactacatac atccaggaat ctgaagtcag atagtaagga tgtggtacca atcctcccga   2520

gtgcaatgct aaacacttcc aggtgggaat tcatctattt cacttaacac aaacgcaggg   2580

tctgtatttc ctgccaacaa gattgagtat ctttccattg cttctctcag tctctgtctt   2640

tgaatatctg aatgttctgg cccttcaaca aattctttaa atcatgctaa ggaatttcgt   2700

tttatgtgga cacactcaac tttgatattc aggagatgtt tttacaaaat gactaattga   2760

aaaaagttga aacaaatgat tttaaaagct tgcagtaaaa aataaactca tagattcagc   2820

aaatatttgt tgactaaaat tatagcattt ttaatgcaga aaattataaa gaatttggag   2880

attgagctgc cttatttcta atgaacactc ctcttcatct tattaagtct tcacagtttt   2940

tccagtggct ataattatgg aattggtgac ctatgtttta tattatcaag gaagccttag   3000

attcactctg atctaagaaa ttattgaaat tgaccctttt tacacaaatg tctttaaaaa   3060

aa                                                                  3062


<210>  640
<211>  502
<212>  PRT
<213>  Homosapiens

<400>  640

Met Asp Val Val Ala Arg Gly Thr Thr Thr Arg Arg Ser Arg Leu Lys 
1               5                   10                  15      


Arg Ser Asp Gly Ser Thr Thr Ser Thr Ser Phe Ile Leu Arg Gln Gly 
            20                  25                  30          


Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val Ser Leu 
        35                  40                  45              


Glu Glu Asp Arg Glu Ala Ile Arg Gln Glu Arg Glu Gln Gln Ala Ala 
    50                  55                  60                  


Ile Gln Leu Glu Arg Ala Lys Ser Lys Pro Val Ala Phe Ala Val Lys 
65                  70                  75                  80  


Thr Asn Val Ser Tyr Cys Gly Ala Leu Asp Glu Asp Val Pro Val Pro 
                85                  90                  95      


Ser Thr Ala Ile Ser Phe Asp Ala Lys Asp Phe Leu His Ile Lys Glu 
            100                 105                 110         


Lys Tyr Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly Cys 
        115                 120                 125             


Glu Ile Gly Phe Ile Pro Ser Pro Leu Arg Leu Glu Asn Ile Arg Ile 
    130                 135                 140                 


Gln Gln Glu Gln Lys Arg Gly Arg Phe His Gly Gly Lys Ser Ser Gly 
145                 150                 155                 160 


Asn Ser Ser Ser Ser Leu Gly Glu Met Val Ser Gly Thr Phe Arg Ala 
                165                 170                 175     


Thr Pro Thr Ser Thr Ala Lys Gln Lys Gln Lys Val Thr Glu His Ile 
            180                 185                 190         


Pro Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu Val Gly 
        195                 200                 205             


Pro Ser Leu Lys Gly Tyr Glu Val Thr Asp Met Met Gln Lys Ala Leu 
    210                 215                 220                 


Phe Asp Phe Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile Thr Arg 
225                 230                 235                 240 


Val Thr Ala Asp Ile Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro 
                245                 250                 255     


Ser Lys Arg Ala Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser Leu Ala 
            260                 265                 270         


Glu Val Gln Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg Ser Leu 
        275                 280                 285             


Gln Leu Val Val Leu Asp Ala Asp Thr Ile Asn His Pro Ala Gln Leu 
    290                 295                 300                 


Ile Lys Thr Ser Leu Ala Pro Ile Ile Val His Val Lys Val Ser Ser 
305                 310                 315                 320 


Pro Lys Val Leu Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser Gln Ser 
                325                 330                 335     


Lys His Leu Asn Val Gln Leu Val Ala Ala Asp Lys Leu Ala Gln Cys 
            340                 345                 350         


Pro Pro Glu Met Phe Asp Val Ile Leu Asp Glu Asn Gln Leu Glu Asp 
        355                 360                 365             


Ala Cys Glu His Leu Gly Glu Tyr Leu Glu Ala Tyr Trp Arg Ala Thr 
    370                 375                 380                 


His Thr Thr Ser Ser Thr Pro Met Thr Pro Leu Leu Gly Arg Asn Leu 
385                 390                 395                 400 


Gly Ser Thr Ala Leu Ser Pro Tyr Pro Thr Ala Ile Ser Gly Leu Gln 
                405                 410                 415     


Ser Gln Arg Met Arg His Ser Asn His Ser Thr Glu Asn Ser Pro Ile 
            420                 425                 430         


Glu Arg Arg Ser Leu Met Thr Ser Asp Glu Asn Tyr His Asn Glu Arg 
        435                 440                 445             


Ala Arg Lys Ser Arg Asn Arg Leu Ser Ser Ser Ser Gln His Ser Arg 
    450                 455                 460                 


Asp His Tyr Pro Leu Val Glu Glu Asp Tyr Pro Asp Ser Tyr Gln Asp 
465                 470                 475                 480 


Thr Tyr Lys Pro His Arg Asn Arg Gly Ser Pro Gly Gly Tyr Ser His 
                485                 490                 495     


Asp Ser Arg His Arg Leu 
            500         


<210>  641
<211>  3185
<212>  DNA
<213>  Homosapiens

<400>  641
gtgctctgta ttgggaaggc agataaaatg ccaggtctgg actgcctctg gggataacct     60

caccctgtgg gatgtgaatg aatagcatct tgcctggtaa atccacagga attgataagg    120

caggcgcagt tctcccaaac aggccttttc tctttaagct gtagctgtgg tttctgcagc    180

aattttgttt ttgccttgaa agaggtgctc tggattatca cacctccatg tatgacaatt    240

tgtacctgca tggaattgaa gactcggagg ctggttcagc ggattcctac acaagcaggc    300

cgtctgactc cgatgtctct ttggaagagg accgggaagc aattcgacag gagagagaac    360

agcaagcagc tatccagctt gagagagcaa agtccaaacc tgtagcattt gccgtgaaga    420

caaatgtgag ctactgcggc gccctggacg aggatgtgcc tgttccaagc acagctatct    480

cctttgatgc taaagacttt ctacatatta aagagaaata taacaatgat tggtggatag    540

gaaggctggt gaaagagggc tgtgaaattg gcttcattcc aagtccactc agattggaga    600

acatacggat ccagcaagaa caaaaaagag gacgttttca cggagggaaa tcaagtggaa    660

attcttcttc aagtcttgga gaaatggtat ctgggacatt ccgagcaact cccacatcaa    720

cagcaaaaca gaagcaaaaa gtgacggagc acattcctcc ttacgatgtt gtaccgtcaa    780

tgcgtccggt ggtgttagtg gggccgtcac tgaaaggtta cgaggtaaca gacatgatgc    840

agaaagccct ctttgatttc ctgaagcaca ggtttgatgg gaggatttca ataacgagag    900

tgacagctga catttctctt gctaagaggt ctgtcctaaa taatcccagc aagagagcaa    960

taattgaacg ttcgaacacc cggtccagct tagcggaagt acaaagtgaa attgaaagaa   1020

tctttgagtt ggcaagatct ttgcaactgg ttgttcttga tgcagacacc atcaatcacc   1080

cagcacaact tataaagact tccttagcac caattattgt tcatgtaaaa gtctcatctc   1140

caaaggtttt acagcggttg attaaatcta gaggaaagtc acaaagtaaa cacttgaatg   1200

ttcaactggt ggcagctgat aaacttgcac aatgcccccc agaaatgttt gatgttatat   1260

tggatgaaaa tcagcttgag gatgcatgtg aacatctagg ggagtacctg gaggcgtact   1320

ggcgtgccac ccacacaacc agtagcacac ccatgacccc gctgctggga aggaatttgg   1380

gctccacggc actctcacca tatcccacag caatttctgg gttacagagt cagcgaatga   1440

ggcacagcaa ccactccaca gagaactctc caattgaaag acgaagtcta atgacctctg   1500

atgaaaatta tcacaatgaa agggctcgga agagtaggaa ccgcttgtct tccagttctc   1560

agcatagccg agatcattac cctcttgtgg aagaagatta ccctgactca taccaggaca   1620

cttacaaacc ccataggaac cgaggatcac ctgggggata tagccatgac tcccgacata   1680

ggctttgagt ctaatgaaac aaaaaatatt catctgttga caatttgcca tagcagtgct   1740

aggataaacc aatcatctta acttggctaa catagcacag tatttactgt gctaatgggc   1800

tgctgtcatt ttatgctaag taaggggcaa aaaaaaaaat tacattatgc ccttgagtct   1860

agatggatat tagatgcccg atcatataga tatttttaag tgcaacattt acatgataac   1920

agtacatttt gttttcttca tagatttaga cacatcaatt tgtaatttag ggtacttaca   1980

aggcacatat aaaataattt cccatgctgg aaattccaaa tgaccagttc cagttggaac   2040

caatttataa accaattcct gttggaattt gggtgaattg actagaaagt ctacttgagc   2100

atgttgtaat caactgaaaa atctgggggg aaaaaaaaaa aactaataag aaaatcgaaa   2160

taccaataga agccaaatcc agctttggta tttatttgct ggaagctaaa tttacactta   2220

aagttggagt gtataaacat tttaatatat gttaatgttg ccagaatgac ttttcagact   2280

taccaaatgt attgatagtg ccaaaaaaaa aatctcagaa atcttaatgc agaaattata   2340

tagtctcctc agattttaat atttttattt ctttcctggc acagctgttg tattcaaagt   2400

gttttgcttt ttgtttggtc agtactgtta gctcatttga agttggcaaa aacaaataca   2460

aacaagcaaa aaacctcaaa tttttttcag cagtgagaga gaatagtaaa gagaggccca   2520

agcatagctg gttatgtgaa atataaaatg gggtgttgtt ctccctttaa tcaatctgag   2580

cacaactaca tacatccagg aatctgaagt cagatagtaa ggatgtggta ccaatcctcc   2640

cgagtgcaat gctaaacact tccaggtggg aattcatcta tttcacttaa cacaaacgca   2700

gggtctgtat ttcctgccaa caagattgag tatctttcca ttgcttctct cagtctctgt   2760

ctttgaatat ctgaatgttc tggcccttca acaaattctt taaatcatgc taaggaattt   2820

cgttttatgt ggacacactc aactttgata ttcaggagat gtttttacaa aatgactaat   2880

tgaaaaaagt tgaaacaaat gattttaaaa gcttgcagta aaaaataaac tcatagattc   2940

agcaaatatt tgttgactaa aattatagca tttttaatgc agaaaattat aaagaatttg   3000

gagattgagc tgccttattt ctaatgaaca ctcctcttca tcttattaag tcttcacagt   3060

ttttccagtg gctataatta tggaattggt gacctatgtt ttatattatc aaggaagcct   3120

tagattcact ctgatctaag aaattattga aattgaccct ttttacacaa atgtctttaa   3180

aaaaa                                                               3185


<210>  642
<211>  486
<212>  PRT
<213>  Homosapiens

<400>  642

Met Tyr Asp Asn Leu Tyr Leu His Gly Ile Glu Asp Ser Glu Ala Gly 
1               5                   10                  15      


Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val Ser Leu 
            20                  25                  30          


Glu Glu Asp Arg Glu Ala Ile Arg Gln Glu Arg Glu Gln Gln Ala Ala 
        35                  40                  45              


Ile Gln Leu Glu Arg Ala Lys Ser Lys Pro Val Ala Phe Ala Val Lys 
    50                  55                  60                  


Thr Asn Val Ser Tyr Cys Gly Ala Leu Asp Glu Asp Val Pro Val Pro 
65                  70                  75                  80  


Ser Thr Ala Ile Ser Phe Asp Ala Lys Asp Phe Leu His Ile Lys Glu 
                85                  90                  95      


Lys Tyr Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly Cys 
            100                 105                 110         


Glu Ile Gly Phe Ile Pro Ser Pro Leu Arg Leu Glu Asn Ile Arg Ile 
        115                 120                 125             


Gln Gln Glu Gln Lys Arg Gly Arg Phe His Gly Gly Lys Ser Ser Gly 
    130                 135                 140                 


Asn Ser Ser Ser Ser Leu Gly Glu Met Val Ser Gly Thr Phe Arg Ala 
145                 150                 155                 160 


Thr Pro Thr Ser Thr Ala Lys Gln Lys Gln Lys Val Thr Glu His Ile 
                165                 170                 175     


Pro Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu Val Gly 
            180                 185                 190         


Pro Ser Leu Lys Gly Tyr Glu Val Thr Asp Met Met Gln Lys Ala Leu 
        195                 200                 205             


Phe Asp Phe Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile Thr Arg 
    210                 215                 220                 


Val Thr Ala Asp Ile Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro 
225                 230                 235                 240 


Ser Lys Arg Ala Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser Leu Ala 
                245                 250                 255     


Glu Val Gln Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg Ser Leu 
            260                 265                 270         


Gln Leu Val Val Leu Asp Ala Asp Thr Ile Asn His Pro Ala Gln Leu 
        275                 280                 285             


Ile Lys Thr Ser Leu Ala Pro Ile Ile Val His Val Lys Val Ser Ser 
    290                 295                 300                 


Pro Lys Val Leu Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser Gln Ser 
305                 310                 315                 320 


Lys His Leu Asn Val Gln Leu Val Ala Ala Asp Lys Leu Ala Gln Cys 
                325                 330                 335     


Pro Pro Glu Met Phe Asp Val Ile Leu Asp Glu Asn Gln Leu Glu Asp 
            340                 345                 350         


Ala Cys Glu His Leu Gly Glu Tyr Leu Glu Ala Tyr Trp Arg Ala Thr 
        355                 360                 365             


His Thr Thr Ser Ser Thr Pro Met Thr Pro Leu Leu Gly Arg Asn Leu 
    370                 375                 380                 


Gly Ser Thr Ala Leu Ser Pro Tyr Pro Thr Ala Ile Ser Gly Leu Gln 
385                 390                 395                 400 


Ser Gln Arg Met Arg His Ser Asn His Ser Thr Glu Asn Ser Pro Ile 
                405                 410                 415     


Glu Arg Arg Ser Leu Met Thr Ser Asp Glu Asn Tyr His Asn Glu Arg 
            420                 425                 430         


Ala Arg Lys Ser Arg Asn Arg Leu Ser Ser Ser Ser Gln His Ser Arg 
        435                 440                 445             


Asp His Tyr Pro Leu Val Glu Glu Asp Tyr Pro Asp Ser Tyr Gln Asp 
    450                 455                 460                 


Thr Tyr Lys Pro His Arg Asn Arg Gly Ser Pro Gly Gly Tyr Ser His 
465                 470                 475                 480 


Asp Ser Arg His Arg Leu 
                485     


<210>  643
<211>  7644
<212>  DNA
<213>  Homosapiens

<400>  643
agcggaggct ttgctgtggc agctgctgga gcggcggccg cctcgggagc cggaggagag     60

gcagccgcgg agcgccgagc tggcctcgcc ccgaggcccg gccctgggtg tggggaaccg    120

cgctgaggag ctggaaactt tcccggcagg agctgactgc tgggcaggaa cgtctctcag    180

gagaaagagt ggaagagaaa attgtgaact aaggccccct gccccctttt cctggtgcat    240

gtgaagttat caaaaacaga aacaagtgtt gaaaatgtta aaggctgtgc tgaagaagag    300

ccgagaggga ggaaagggag gcaagaagga agcaggaagt gactttggtc cagagacttc    360

tccagtcctg caccttgacc acagtgctga ctctcctgtg agcagtcttc ccacagcaga    420

ggacacctat agggtgagct tggccaaagg tgtctcgatg tctctgcctt cctcaccttt    480

gctgcctcga cagtctcact tggtgcaatc aagagtgaac aaaaaatccc caggtcccgt    540

caggaagccc aagtatgtgg aaagccccag agtgcctgga gatgcagtta taatgccatt    600

cagagaagta gccaagccaa cagagcctga tgagcatgaa gcaaaggccg ataatgaacc    660

gagctgttcg ccggcagctc aagaactgtt gacaaggctg ggatttttac tgggagaagg    720

gatcccaagt gccacacaca taaccattga agacaaaaat gaaaccatgt gcacagctct    780

gagtcaaggc atcagtcctt gctccacact aacaagcagc accgcatctc ctagcaccga    840

tagcccctgc tcaaccttga atagctgtgt cagcaagacg gcagccaaca aaagtccctg    900

tgagaccatt agcagcccta gttccaccct ggaaagcaag gacagtggaa ttatagccac    960

aattacaagt tcatccgaaa atgatgaccg gagtggctcc agtttggaat ggaataaaga   1020

tggaagccta agattagggg ttcagaaggg agtgcttcat gaccgcaggg cagataactg   1080

ctccccagtg gcagaagagg agaccaccgg gtcagcagag agcacgctgc ccaaagcaga   1140

atcctcagct ggagatggtc cagtccctta ttctcagggc tccagctcac taataatgcc   1200

acggcccaac tcagttgcag caacaagctc aaccaaattg gaagatctga gttatttaga   1260

cgggcagaga aatgctcctc tacggacgtc aattagatta ccatggcaca atacggccgg   1320

aggtagggca caggaagtta aagcacgatt tgctccctac aagccacaag acattttgtt   1380

gaaacccttg ttgtttgaag taccaagcat aacaacagac tctgtgtttg tgggaaggga   1440

ttggctcttt caccagatag aagaaaactt gaggaacaca gaactggcag aaaacagagg   1500

cgcggtggtg gttggcaatg tgggatttgg gaagacggca atcatttcca agttggtggc   1560

cctgagctgc cacggaagcc gcatgaggca gattgcttcc aacagcccgg gttcatcacc   1620

taaaacctct gaccccactc aggatcttca tttcactccg ttgctttcac cgagttcttc   1680

cacaagtgct tccagcacag ctaaaacacc tcttgggtct atcagtgctg aaaaccagag   1740

accaagagag gatgcagtga aatatcttgc ttctaaggtg gtggcctacc actactgcca   1800

ggctgacaac acgtacactt gcctggtgcc cgagtttgtg cacagcatcg cagctttgct   1860

ctgccggtcc catcagctgg ccgcctacag agaccttctg ataaaggagc cccaactaca   1920

gagcatgctg agcctccgat cctgtgtgca ggacccggtg gcagctttca agaggggagt   1980

gctggagcca ctcacaaacc tgagaaatga gcagaaaatt cctgaagaag aatacattat   2040

tttgatagat ggcttaaatg aagctgagtt tcataaacct gattatggag atacgctttc   2100

ttcatttatt accaaaatta tttctaaatt tcctgcctgg ttgaagttga ttgtgactgt   2160

aagagcaaat tttcaggaaa tcataagtgc gctgccattt gtcaagcttt ccttagatga   2220

cttcccagac aacaaagaca tccacagtga cctgcacgcc tacgtccagc acagggtgca   2280

cagcagccag gacatcctca gcaacatctc cctgaacggc aaggccgatg ccacactcat   2340

tggaaaagtg agcagccacc tggtgctgcg gagcctcggc tcctacctgt acctcaagct   2400

caccctggac cttttccaga ggggccactt ggtcattaag agtgccagct acaaggtggt   2460

gcccgtgtct ctctctgagc tctatttgct tcagtgcaac atgaagttca tgacccagtc   2520

cgcctttgag agggcacttc cgattctcaa cgtggccctc gcatccctcc accccatgac   2580

agacgagcag atctttcagg ctattaatgc tggccacatc cagggggagc agggatggga   2640

agactttcag cagaggatgg acgccctctc ctgcttcctc attaagaggc gagacaaaac   2700

ccgcatgttc tgccacccgt ccttcaggga gtggcttgta tggagagcag acggggaaaa   2760

cacggccttc ctgtgtgagc ccaggaacgg gcacgcgctc ttggcattca tgttctcgcg   2820

tcaggagggc aagttgaacc gccagcagac catggagctt ggccaccaca tcctgaaggc   2880

gcacattttc aagggcctca gtaagaagac gggaatttct tcaagccatc tccaagccct   2940

gtggatcggc tacagcaccg aggggctgtc cgccgccctg gcctctctca ggaatctcta   3000

tactcccaac gtgaaggtga gccgtctcct gattttggga ggggccaacg tgaactacag   3060

gacagaagtg ttaaataatg ccccaatcct gtgcgtccag tctcaccttg gccacgagga   3120

agttgtcact ctgctcctgg aatttggtgc ctgcctggac ggaacgtcag agaacggcat   3180

gactgccctc tgttacgcag cagctgctgg ccacatgaag ctggtgtgtc tgctgaccaa   3240

gaagggagtg agagtggacc acttggataa gaagggccag tgtgcgcttg tccacagtgc   3300

cctacggggc cacggtgaca ttctccagta cctgctgact tgtgagtggt cgccgggtcc   3360

tccccagcca ggcaccctga ggaagagcca cgccctgcag caggcgctga ccgcggcggc   3420

cagcatgggc cacagctcgg tggtccagtg cttgctgggg atggagaagg aacatgaagt   3480

agaagtcaat ggcaccgaca cattgtgggg agaaacagcc ctgactgccg ccgcaggaag   3540

agggaagctg gaggtctgtg agctgctgct ggggcatgga gctgctgtgt cgcggacaaa   3600

caggagaggg gttccacctt tgttttgtgc agcacgccag gggcattggc agattgttag   3660

actgctgttg gaacgcggct gtgatgtgaa cctaagtgac aagcaaggcc ggacgcccct   3720

catggtggct gcttgtgaag ggcacttgag caccgtggaa ttcctccttt caaaaggtgc   3780

agccctttct tctctagaca aagagggtct gtcagcatta agctgggctt gtctgaaagg   3840

tcacagggca gtggtccagt atctggttga agaaggagct gcaatagacc agacagacaa   3900

gaatggccgc acacccttgg acctggctgc cttctatggc gatgccgaga ctgtgctgta   3960

cctggtggag aagggagccg tgatcgagca tgtggaccac agcgggatgc ggcccttgga   4020

cagagccatc ggctgccgga acacatctgt agtggtggcg ctactcagaa agggagccaa   4080

gttaggaaat gctgcttggg cgatggccac ttccaaacct gatatcttga ttatactttt   4140

acagaaatta atggaggaag gaaatgtgat gtacaaaaaa gggaaaatga aagaggcagc   4200

ccagaggtac cagtatgcct taagaaagtt tcctcgagaa ggattcggag aggacatgag   4260

acccttcaat gaattaaggg tttccctcta tctcaatttg tcgcgatgcc gaagaaaaac   4320

aaatgacttt ggcatggcag aggaatttgc ttccaaggct ctcgaattga agcccaagtc   4380

ctatgaagcc ttttatgcca gagcaagagc gaagagaaat agcaggcaat tcgtggcagc   4440

tctggctgac ctgcaagagg ctgtgaaact ctgtcccacc aatcaggaag tcaagaggct   4500

tctggcccgc gtagaagagg agtgcaaaca actccagagg agtcaacagc aaaaacagca   4560

gggcccgcta ccagctccac tcaacgactc cgagaacgaa gaggacaccc caacccctgg   4620

cttaagtgac cactttcact ctgaggagac tgaagaggaa gaaacttctc cccaggaaga   4680

atctgtttcc ccaactccca ggtcccagcc atcctcatct gtcccttcct catacatccg   4740

aaaccttcaa gaagggttac agtccaaagg aaggccggta tcgccacaga gcagggcagg   4800

aatcggcaag tccctgagag agcctgtggc ccagccaggg ctgctcctgc agccctccaa   4860

gcaggcccag atcgtgaaaa ccagccagca cctgggctct ggccagtcgg cagtgagaaa   4920

tggcagtatg aaagttcaga tctcttctca gaaccctcct ccaagtccca tgccagggag   4980

aatcgctgcc actcctgctg ggagcagaac ccagcattta gagggaacag gtactttcac   5040

tacaagagct ggttgtggcc actttgggga tcggctgggc cccagccaga atgtccgcct   5100

gcagtgtggt gagaatggcc ctgcacaccc tttaccaagt aagacgaaaa ccacagagag   5160

gcttctgtct cattcctccg tggctgtgga cgcagcccct ccaaaccaag gtgggctggc   5220

gacctgcagc gacgtgcgac acccagcttc cctcaccagc tcaggctctt ctggttctcc   5280

atccagcagc ataaagatgt caagttcaac cagtagtttg acttcgagca gcagtttttc   5340

agatggcttc aaggtccaag gaccagatac tagaattaaa gacaaggttg taacccacgt   5400

tcagagcggt acagctgagc acagaccccg caacacgccg ttcatgggca tcatggataa   5460

gactgcgagg ttccaacagc agagcaatcc tccaagccgc agctggcact gtccggcacc   5520

agaggggctg ctgacaaaca cgtcttctgc agctggcctg cagtctgcta acactgagaa   5580

gccctctctc atgcaagtgg gaggatataa taaccaagcc aaaacctgtt ctgtttctac   5640

cctgagtgca agtgtccaca atggggcaca agtgaaggag ctagaagaaa gcaagtgcca   5700

aattccagtc cactctcaag agaacaggat aactaagact gtttctcatc tgtaccagga   5760

aagtatctcc aaacagcagc ctcatattag taatgaagcc cacaggagcc acctcactgc   5820

agccaaacca aagcgatcat ttatagagtc aaatgtgtga accttaagaa atccccattt   5880

gtggaatttg gaaacgtgtg ttgactcctg gtggtaaatt aaatagtttt tttcatcaga   5940

aaaattattt tttagccatt ttttttcttt ggggtggatc tgatgccatt gatatatcta   6000

aaatgtggga taaaacttct ttaatagcta gaaatcacca taaataagaa tgctaaacag   6060

aattgaaaat tatatcaact taaaatttta agacagccca gaagacatta atgactctca   6120

cttatgaaat tgtttggctt ttgccacttt cttccttgcc tttgctatat ggtagaatca   6180

cagaacttac ttagagaata aatatgtcta ttgttcaaga gtaacaggtt taactcatga   6240

ccaagtgatg tacatccaag tgatgtattc tggaaacgat ggaattttac agttacagtt   6300

ccattgagtc aaatcccatt ttatatatac ataaaaatta agttctgagt gagttctagc   6360

taaatataag tgcgactgta aacgcagcca atttttttaa gcagaatatg agaacaccta   6420

agtattctct tcatagcagt tcctataaag ggattaaaca cttatttctg tgttatggtt   6480

cttattcata tatttttata gcacttttgg aacctatatt tgtgcttgaa ggtgtttttg   6540

atatttggaa acagtataag ccatttggag tcatgattgg tggtcaagtg gattcaagct   6600

aaaatactaa gaccagcatt cttagtggcg cttataaatt agctctcacc tggtttccaa   6660

actgctttta acaatggtag tgctcctgga acaatccttc caagctcctc taaggacaat   6720

atttaattca gatactaaag gtaagactgg ttgttacttt tgttttgttg tacaattagt   6780

actttatagt cacatgttgt atatattaaa tagcccagtt ttattcagac ttgtaaatag   6840

aactatttca atgtagttaa tctaaaaaca aaaaagaaaa ccccagtcac gatttgcatg   6900

ttctctgtaa gcttcatcca tgctggttat tgcactgaat gatatattat tagggcatgt   6960

taacagtata ccagtaacag cactttatct catttatatg aacacctttg aggtgctact   7020

taagtccaag ctctgatgta ttattcattt gtaaagataa ggtacaggaa tgaaccttgg   7080

tttaaaggta tttttatatg aaaatggtgt gttattggaa gatgttaaaa tgctaatttg   7140

agagaagtag gagtgtatct gttttatatg ttgggatgtg aaatttattt tctaaaattg   7200

aggagaagga agttatatat ttgcagaatg ttttaaagtg aattgttgta atgaagttcc   7260

tgtgaacatc attatggttt tgtacaaata ggaacctctg atgtcattct tcaacgtttg   7320

ttcctgtgtg tacaattgta ctttgtatga acagctttat catttttata ggctttccat   7380

gagttttgct gtaactacta tggcttattt attttcttta atatttgtga aagtcttact   7440

cctttgttag ttttgtttct gcacaactac tgtacttttc catatggaat aaagactatt   7500

aatagaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   7560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   7620

aaaaaaaaaa aaaaaaaaaa aaaa                                          7644


<210>  644
<211>  1861
<212>  PRT
<213>  Homosapiens

<400>  644

Met Leu Lys Ala Val Leu Lys Lys Ser Arg Glu Gly Gly Lys Gly Gly 
1               5                   10                  15      


Lys Lys Glu Ala Gly Ser Asp Phe Gly Pro Glu Thr Ser Pro Val Leu 
            20                  25                  30          


His Leu Asp His Ser Ala Asp Ser Pro Val Ser Ser Leu Pro Thr Ala 
        35                  40                  45              


Glu Asp Thr Tyr Arg Val Ser Leu Ala Lys Gly Val Ser Met Ser Leu 
    50                  55                  60                  


Pro Ser Ser Pro Leu Leu Pro Arg Gln Ser His Leu Val Gln Ser Arg 
65                  70                  75                  80  


Val Asn Lys Lys Ser Pro Gly Pro Val Arg Lys Pro Lys Tyr Val Glu 
                85                  90                  95      


Ser Pro Arg Val Pro Gly Asp Ala Val Ile Met Pro Phe Arg Glu Val 
            100                 105                 110         


Ala Lys Pro Thr Glu Pro Asp Glu His Glu Ala Lys Ala Asp Asn Glu 
        115                 120                 125             


Pro Ser Cys Ser Pro Ala Ala Gln Glu Leu Leu Thr Arg Leu Gly Phe 
    130                 135                 140                 


Leu Leu Gly Glu Gly Ile Pro Ser Ala Thr His Ile Thr Ile Glu Asp 
145                 150                 155                 160 


Lys Asn Glu Thr Met Cys Thr Ala Leu Ser Gln Gly Ile Ser Pro Cys 
                165                 170                 175     


Ser Thr Leu Thr Ser Ser Thr Ala Ser Pro Ser Thr Asp Ser Pro Cys 
            180                 185                 190         


Ser Thr Leu Asn Ser Cys Val Ser Lys Thr Ala Ala Asn Lys Ser Pro 
        195                 200                 205             


Cys Glu Thr Ile Ser Ser Pro Ser Ser Thr Leu Glu Ser Lys Asp Ser 
    210                 215                 220                 


Gly Ile Ile Ala Thr Ile Thr Ser Ser Ser Glu Asn Asp Asp Arg Ser 
225                 230                 235                 240 


Gly Ser Ser Leu Glu Trp Asn Lys Asp Gly Ser Leu Arg Leu Gly Val 
                245                 250                 255     


Gln Lys Gly Val Leu His Asp Arg Arg Ala Asp Asn Cys Ser Pro Val 
            260                 265                 270         


Ala Glu Glu Glu Thr Thr Gly Ser Ala Glu Ser Thr Leu Pro Lys Ala 
        275                 280                 285             


Glu Ser Ser Ala Gly Asp Gly Pro Val Pro Tyr Ser Gln Gly Ser Ser 
    290                 295                 300                 


Ser Leu Ile Met Pro Arg Pro Asn Ser Val Ala Ala Thr Ser Ser Thr 
305                 310                 315                 320 


Lys Leu Glu Asp Leu Ser Tyr Leu Asp Gly Gln Arg Asn Ala Pro Leu 
                325                 330                 335     


Arg Thr Ser Ile Arg Leu Pro Trp His Asn Thr Ala Gly Gly Arg Ala 
            340                 345                 350         


Gln Glu Val Lys Ala Arg Phe Ala Pro Tyr Lys Pro Gln Asp Ile Leu 
        355                 360                 365             


Leu Lys Pro Leu Leu Phe Glu Val Pro Ser Ile Thr Thr Asp Ser Val 
    370                 375                 380                 


Phe Val Gly Arg Asp Trp Leu Phe His Gln Ile Glu Glu Asn Leu Arg 
385                 390                 395                 400 


Asn Thr Glu Leu Ala Glu Asn Arg Gly Ala Val Val Val Gly Asn Val 
                405                 410                 415     


Gly Phe Gly Lys Thr Ala Ile Ile Ser Lys Leu Val Ala Leu Ser Cys 
            420                 425                 430         


His Gly Ser Arg Met Arg Gln Ile Ala Ser Asn Ser Pro Gly Ser Ser 
        435                 440                 445             


Pro Lys Thr Ser Asp Pro Thr Gln Asp Leu His Phe Thr Pro Leu Leu 
    450                 455                 460                 


Ser Pro Ser Ser Ser Thr Ser Ala Ser Ser Thr Ala Lys Thr Pro Leu 
465                 470                 475                 480 


Gly Ser Ile Ser Ala Glu Asn Gln Arg Pro Arg Glu Asp Ala Val Lys 
                485                 490                 495     


Tyr Leu Ala Ser Lys Val Val Ala Tyr His Tyr Cys Gln Ala Asp Asn 
            500                 505                 510         


Thr Tyr Thr Cys Leu Val Pro Glu Phe Val His Ser Ile Ala Ala Leu 
        515                 520                 525             


Leu Cys Arg Ser His Gln Leu Ala Ala Tyr Arg Asp Leu Leu Ile Lys 
    530                 535                 540                 


Glu Pro Gln Leu Gln Ser Met Leu Ser Leu Arg Ser Cys Val Gln Asp 
545                 550                 555                 560 


Pro Val Ala Ala Phe Lys Arg Gly Val Leu Glu Pro Leu Thr Asn Leu 
                565                 570                 575     


Arg Asn Glu Gln Lys Ile Pro Glu Glu Glu Tyr Ile Ile Leu Ile Asp 
            580                 585                 590         


Gly Leu Asn Glu Ala Glu Phe His Lys Pro Asp Tyr Gly Asp Thr Leu 
        595                 600                 605             


Ser Ser Phe Ile Thr Lys Ile Ile Ser Lys Phe Pro Ala Trp Leu Lys 
    610                 615                 620                 


Leu Ile Val Thr Val Arg Ala Asn Phe Gln Glu Ile Ile Ser Ala Leu 
625                 630                 635                 640 


Pro Phe Val Lys Leu Ser Leu Asp Asp Phe Pro Asp Asn Lys Asp Ile 
                645                 650                 655     


His Ser Asp Leu His Ala Tyr Val Gln His Arg Val His Ser Ser Gln 
            660                 665                 670         


Asp Ile Leu Ser Asn Ile Ser Leu Asn Gly Lys Ala Asp Ala Thr Leu 
        675                 680                 685             


Ile Gly Lys Val Ser Ser His Leu Val Leu Arg Ser Leu Gly Ser Tyr 
    690                 695                 700                 


Leu Tyr Leu Lys Leu Thr Leu Asp Leu Phe Gln Arg Gly His Leu Val 
705                 710                 715                 720 


Ile Lys Ser Ala Ser Tyr Lys Val Val Pro Val Ser Leu Ser Glu Leu 
                725                 730                 735     


Tyr Leu Leu Gln Cys Asn Met Lys Phe Met Thr Gln Ser Ala Phe Glu 
            740                 745                 750         


Arg Ala Leu Pro Ile Leu Asn Val Ala Leu Ala Ser Leu His Pro Met 
        755                 760                 765             


Thr Asp Glu Gln Ile Phe Gln Ala Ile Asn Ala Gly His Ile Gln Gly 
    770                 775                 780                 


Glu Gln Gly Trp Glu Asp Phe Gln Gln Arg Met Asp Ala Leu Ser Cys 
785                 790                 795                 800 


Phe Leu Ile Lys Arg Arg Asp Lys Thr Arg Met Phe Cys His Pro Ser 
                805                 810                 815     


Phe Arg Glu Trp Leu Val Trp Arg Ala Asp Gly Glu Asn Thr Ala Phe 
            820                 825                 830         


Leu Cys Glu Pro Arg Asn Gly His Ala Leu Leu Ala Phe Met Phe Ser 
        835                 840                 845             


Arg Gln Glu Gly Lys Leu Asn Arg Gln Gln Thr Met Glu Leu Gly His 
    850                 855                 860                 


His Ile Leu Lys Ala His Ile Phe Lys Gly Leu Ser Lys Lys Thr Gly 
865                 870                 875                 880 


Ile Ser Ser Ser His Leu Gln Ala Leu Trp Ile Gly Tyr Ser Thr Glu 
                885                 890                 895     


Gly Leu Ser Ala Ala Leu Ala Ser Leu Arg Asn Leu Tyr Thr Pro Asn 
            900                 905                 910         


Val Lys Val Ser Arg Leu Leu Ile Leu Gly Gly Ala Asn Val Asn Tyr 
        915                 920                 925             


Arg Thr Glu Val Leu Asn Asn Ala Pro Ile Leu Cys Val Gln Ser His 
    930                 935                 940                 


Leu Gly His Glu Glu Val Val Thr Leu Leu Leu Glu Phe Gly Ala Cys 
945                 950                 955                 960 


Leu Asp Gly Thr Ser Glu Asn Gly Met Thr Ala Leu Cys Tyr Ala Ala 
                965                 970                 975     


Ala Ala Gly His Met Lys Leu Val Cys Leu Leu Thr Lys Lys Gly Val 
            980                 985                 990         


Arg Val Asp His Leu Asp Lys Lys  Gly Gln Cys Ala Leu  Val His Ser 
        995                 1000                 1005             


Ala Leu  Arg Gly His Gly Asp  Ile Leu Gln Tyr Leu  Leu Thr Cys 
    1010                 1015                 1020             


Glu Trp  Ser Pro Gly Pro Pro  Gln Pro Gly Thr Leu  Arg Lys Ser 
    1025                 1030                 1035             


His Ala  Leu Gln Gln Ala Leu  Thr Ala Ala Ala Ser  Met Gly His 
    1040                 1045                 1050             


Ser Ser  Val Val Gln Cys Leu  Leu Gly Met Glu Lys  Glu His Glu 
    1055                 1060                 1065             


Val Glu  Val Asn Gly Thr Asp  Thr Leu Trp Gly Glu  Thr Ala Leu 
    1070                 1075                 1080             


Thr Ala  Ala Ala Gly Arg Gly  Lys Leu Glu Val Cys  Glu Leu Leu 
    1085                 1090                 1095             


Leu Gly  His Gly Ala Ala Val  Ser Arg Thr Asn Arg  Arg Gly Val 
    1100                 1105                 1110             


Pro Pro  Leu Phe Cys Ala Ala  Arg Gln Gly His Trp  Gln Ile Val 
    1115                 1120                 1125             


Arg Leu  Leu Leu Glu Arg Gly  Cys Asp Val Asn Leu  Ser Asp Lys 
    1130                 1135                 1140             


Gln Gly  Arg Thr Pro Leu Met  Val Ala Ala Cys Glu  Gly His Leu 
    1145                 1150                 1155             


Ser Thr  Val Glu Phe Leu Leu  Ser Lys Gly Ala Ala  Leu Ser Ser 
    1160                 1165                 1170             


Leu Asp  Lys Glu Gly Leu Ser  Ala Leu Ser Trp Ala  Cys Leu Lys 
    1175                 1180                 1185             


Gly His  Arg Ala Val Val Gln  Tyr Leu Val Glu Glu  Gly Ala Ala 
    1190                 1195                 1200             


Ile Asp  Gln Thr Asp Lys Asn  Gly Arg Thr Pro Leu  Asp Leu Ala 
    1205                 1210                 1215             


Ala Phe  Tyr Gly Asp Ala Glu  Thr Val Leu Tyr Leu  Val Glu Lys 
    1220                 1225                 1230             


Gly Ala  Val Ile Glu His Val  Asp His Ser Gly Met  Arg Pro Leu 
    1235                 1240                 1245             


Asp Arg  Ala Ile Gly Cys Arg  Asn Thr Ser Val Val  Val Ala Leu 
    1250                 1255                 1260             


Leu Arg  Lys Gly Ala Lys Leu  Gly Asn Ala Ala Trp  Ala Met Ala 
    1265                 1270                 1275             


Thr Ser  Lys Pro Asp Ile Leu  Ile Ile Leu Leu Gln  Lys Leu Met 
    1280                 1285                 1290             


Glu Glu  Gly Asn Val Met Tyr  Lys Lys Gly Lys Met  Lys Glu Ala 
    1295                 1300                 1305             


Ala Gln  Arg Tyr Gln Tyr Ala  Leu Arg Lys Phe Pro  Arg Glu Gly 
    1310                 1315                 1320             


Phe Gly  Glu Asp Met Arg Pro  Phe Asn Glu Leu Arg  Val Ser Leu 
    1325                 1330                 1335             


Tyr Leu  Asn Leu Ser Arg Cys  Arg Arg Lys Thr Asn  Asp Phe Gly 
    1340                 1345                 1350             


Met Ala  Glu Glu Phe Ala Ser  Lys Ala Leu Glu Leu  Lys Pro Lys 
    1355                 1360                 1365             


Ser Tyr  Glu Ala Phe Tyr Ala  Arg Ala Arg Ala Lys  Arg Asn Ser 
    1370                 1375                 1380             


Arg Gln  Phe Val Ala Ala Leu  Ala Asp Leu Gln Glu  Ala Val Lys 
    1385                 1390                 1395             


Leu Cys  Pro Thr Asn Gln Glu  Val Lys Arg Leu Leu  Ala Arg Val 
    1400                 1405                 1410             


Glu Glu  Glu Cys Lys Gln Leu  Gln Arg Ser Gln Gln  Gln Lys Gln 
    1415                 1420                 1425             


Gln Gly  Pro Leu Pro Ala Pro  Leu Asn Asp Ser Glu  Asn Glu Glu 
    1430                 1435                 1440             


Asp Thr  Pro Thr Pro Gly Leu  Ser Asp His Phe His  Ser Glu Glu 
    1445                 1450                 1455             


Thr Glu  Glu Glu Glu Thr Ser  Pro Gln Glu Glu Ser  Val Ser Pro 
    1460                 1465                 1470             


Thr Pro  Arg Ser Gln Pro Ser  Ser Ser Val Pro Ser  Ser Tyr Ile 
    1475                 1480                 1485             


Arg Asn  Leu Gln Glu Gly Leu  Gln Ser Lys Gly Arg  Pro Val Ser 
    1490                 1495                 1500             


Pro Gln  Ser Arg Ala Gly Ile  Gly Lys Ser Leu Arg  Glu Pro Val 
    1505                 1510                 1515             


Ala Gln  Pro Gly Leu Leu Leu  Gln Pro Ser Lys Gln  Ala Gln Ile 
    1520                 1525                 1530             


Val Lys  Thr Ser Gln His Leu  Gly Ser Gly Gln Ser  Ala Val Arg 
    1535                 1540                 1545             


Asn Gly  Ser Met Lys Val Gln  Ile Ser Ser Gln Asn  Pro Pro Pro 
    1550                 1555                 1560             


Ser Pro  Met Pro Gly Arg Ile  Ala Ala Thr Pro Ala  Gly Ser Arg 
    1565                 1570                 1575             


Thr Gln  His Leu Glu Gly Thr  Gly Thr Phe Thr Thr  Arg Ala Gly 
    1580                 1585                 1590             


Cys Gly  His Phe Gly Asp Arg  Leu Gly Pro Ser Gln  Asn Val Arg 
    1595                 1600                 1605             


Leu Gln  Cys Gly Glu Asn Gly  Pro Ala His Pro Leu  Pro Ser Lys 
    1610                 1615                 1620             


Thr Lys  Thr Thr Glu Arg Leu  Leu Ser His Ser Ser  Val Ala Val 
    1625                 1630                 1635             


Asp Ala  Ala Pro Pro Asn Gln  Gly Gly Leu Ala Thr  Cys Ser Asp 
    1640                 1645                 1650             


Val Arg  His Pro Ala Ser Leu  Thr Ser Ser Gly Ser  Ser Gly Ser 
    1655                 1660                 1665             


Pro Ser  Ser Ser Ile Lys Met  Ser Ser Ser Thr Ser  Ser Leu Thr 
    1670                 1675                 1680             


Ser Ser  Ser Ser Phe Ser Asp  Gly Phe Lys Val Gln  Gly Pro Asp 
    1685                 1690                 1695             


Thr Arg  Ile Lys Asp Lys Val  Val Thr His Val Gln  Ser Gly Thr 
    1700                 1705                 1710             


Ala Glu  His Arg Pro Arg Asn  Thr Pro Phe Met Gly  Ile Met Asp 
    1715                 1720                 1725             


Lys Thr  Ala Arg Phe Gln Gln  Gln Ser Asn Pro Pro  Ser Arg Ser 
    1730                 1735                 1740             


Trp His  Cys Pro Ala Pro Glu  Gly Leu Leu Thr Asn  Thr Ser Ser 
    1745                 1750                 1755             


Ala Ala  Gly Leu Gln Ser Ala  Asn Thr Glu Lys Pro  Ser Leu Met 
    1760                 1765                 1770             


Gln Val  Gly Gly Tyr Asn Asn  Gln Ala Lys Thr Cys  Ser Val Ser 
    1775                 1780                 1785             


Thr Leu  Ser Ala Ser Val His  Asn Gly Ala Gln Val  Lys Glu Leu 
    1790                 1795                 1800             


Glu Glu  Ser Lys Cys Gln Ile  Pro Val His Ser Gln  Glu Asn Arg 
    1805                 1810                 1815             


Ile Thr  Lys Thr Val Ser His  Leu Tyr Gln Glu Ser  Ile Ser Lys 
    1820                 1825                 1830             


Gln Gln  Pro His Ile Ser Asn  Glu Ala His Arg Ser  His Leu Thr 
    1835                 1840                 1845             


Ala Ala  Lys Pro Lys Arg Ser  Phe Ile Glu Ser Asn  Val 
    1850                 1855                 1860     


<210>  645
<211>  1811
<212>  DNA
<213>  Homosapiens

<400>  645
agcggcggtg gcggcaggtg gggaagcgcg gctgggcctg ctcgcgcggg gcgtctgagc     60

cctccatttc ccggttctaa ccgcgcagca gggcccaacc gggaccttga gtgcggcgag    120

gcgtggctgt ttttcttcaa ataaagaaca tggtgaaact gattcacaca ttagctgatc    180

atggtgacga tgtcaactgc tgtgccttct ccttttccct cttggctact tgctccttgg    240

acaaaacaat tcgcctgtac tcgttacgtg actttactga actgccacat tctccattga    300

agtttcatac ctatgctgtc cactgctgct gtttctcccc ttcaggacat attttggcat    360

cgtgttcaac agatggtacc actgtcctat ggaatactga aaatggacag atgctggcag    420

tgatggaaca gcctagtggc agccctgtga gggtttgcca gttttcccca gactccacgt    480

gtttggcatc aggggcagct gatggaactg tggttttgtg gaatgcacag tcatacaaat    540

tatatagatg tggtagtgtt aaagatggct ccttggcggc atgtgcattt tctcctaatg    600

gaagcttctt tgtcactggc tcctcatgtg gtgatttaac agtgtgggat gataaaatga    660

ggtgtctgca tagtgaaaaa gcacatgatc ttggaattac ctgctgcgat ttttcttcac    720

agccagtttc tgatggagaa caaggtcttc agttttttcg actggcatca tgtggtcagg    780

attgccaagt caaaatttgg attgtttctt ttacccatat cttaggtttt gaattaaaat    840

ataaaagtac actgagtggg cactgtgctc ctgttctggc ttgtgctttt tcccatgatg    900

ggcagatgct agtctcaggg tcagtggata agtctgtcat agtatatgat actaatactg    960

agaatatact tcacacattg actcagcaca ccaggtatgt cacaacttgt gcttttgcac   1020

ctaataccct tttacttgct actggttcaa tggacaaaac agtgaacatc tggcaatttg   1080

acctggaaac actttgccaa gcaaggagca cagaacatca gctgaagcaa tttaccgaag   1140

attggtcaga ggaggatgtc tcaacatggc tttgtgcaca agatttaaaa gatcttgttg   1200

gtattttcaa gatgaataac attgatggaa aagaactgtt gaatcttaca aaagaaagtc   1260

tggctgatga tttgaaaatt gaatctctag gactgcgtag taaagtgctg aggaaaattg   1320

aagagctcag gaccaaggtt aaatcccttt cttcaggaat tcctgatgaa tttatatgtc   1380

caataactag agaacttatg aaagatccgg tcatcgcatc agatggctat tcatatgaaa   1440

aggaagcaat ggaaaattgg atcagcaaaa agaaacgtac aagtcccatg acaaatcttg   1500

ttcttccttc agcggtactt acaccaaata ggactctgaa aatggccatc aatagatggc   1560

tggagacaca ccaaaagtaa aattgttgat attgtattat ttatattttc agtgatctca   1620

tttgaatgat ttataggtaa atactaatca gacattatta aaagcaaaac aggaaaaagg   1680

taaacttctt aaatttagtt acctataaaa attgtcaatt ttcattcttt aaaaacacat   1740

ggacttacta taaaagcctt tttgtactag tgaaaagaat cttcagctat atagaaataa   1800

agttatactt t                                                        1811


<210>  646
<211>  476
<212>  PRT
<213>  Homosapiens

<400>  646

Met Val Lys Leu Ile His Thr Leu Ala Asp His Gly Asp Asp Val Asn 
1               5                   10                  15      


Cys Cys Ala Phe Ser Phe Ser Leu Leu Ala Thr Cys Ser Leu Asp Lys 
            20                  25                  30          


Thr Ile Arg Leu Tyr Ser Leu Arg Asp Phe Thr Glu Leu Pro His Ser 
        35                  40                  45              


Pro Leu Lys Phe His Thr Tyr Ala Val His Cys Cys Cys Phe Ser Pro 
    50                  55                  60                  


Ser Gly His Ile Leu Ala Ser Cys Ser Thr Asp Gly Thr Thr Val Leu 
65                  70                  75                  80  


Trp Asn Thr Glu Asn Gly Gln Met Leu Ala Val Met Glu Gln Pro Ser 
                85                  90                  95      


Gly Ser Pro Val Arg Val Cys Gln Phe Ser Pro Asp Ser Thr Cys Leu 
            100                 105                 110         


Ala Ser Gly Ala Ala Asp Gly Thr Val Val Leu Trp Asn Ala Gln Ser 
        115                 120                 125             


Tyr Lys Leu Tyr Arg Cys Gly Ser Val Lys Asp Gly Ser Leu Ala Ala 
    130                 135                 140                 


Cys Ala Phe Ser Pro Asn Gly Ser Phe Phe Val Thr Gly Ser Ser Cys 
145                 150                 155                 160 


Gly Asp Leu Thr Val Trp Asp Asp Lys Met Arg Cys Leu His Ser Glu 
                165                 170                 175     


Lys Ala His Asp Leu Gly Ile Thr Cys Cys Asp Phe Ser Ser Gln Pro 
            180                 185                 190         


Val Ser Asp Gly Glu Gln Gly Leu Gln Phe Phe Arg Leu Ala Ser Cys 
        195                 200                 205             


Gly Gln Asp Cys Gln Val Lys Ile Trp Ile Val Ser Phe Thr His Ile 
    210                 215                 220                 


Leu Gly Phe Glu Leu Lys Tyr Lys Ser Thr Leu Ser Gly His Cys Ala 
225                 230                 235                 240 


Pro Val Leu Ala Cys Ala Phe Ser His Asp Gly Gln Met Leu Val Ser 
                245                 250                 255     


Gly Ser Val Asp Lys Ser Val Ile Val Tyr Asp Thr Asn Thr Glu Asn 
            260                 265                 270         


Ile Leu His Thr Leu Thr Gln His Thr Arg Tyr Val Thr Thr Cys Ala 
        275                 280                 285             


Phe Ala Pro Asn Thr Leu Leu Leu Ala Thr Gly Ser Met Asp Lys Thr 
    290                 295                 300                 


Val Asn Ile Trp Gln Phe Asp Leu Glu Thr Leu Cys Gln Ala Arg Ser 
305                 310                 315                 320 


Thr Glu His Gln Leu Lys Gln Phe Thr Glu Asp Trp Ser Glu Glu Asp 
                325                 330                 335     


Val Ser Thr Trp Leu Cys Ala Gln Asp Leu Lys Asp Leu Val Gly Ile 
            340                 345                 350         


Phe Lys Met Asn Asn Ile Asp Gly Lys Glu Leu Leu Asn Leu Thr Lys 
        355                 360                 365             


Glu Ser Leu Ala Asp Asp Leu Lys Ile Glu Ser Leu Gly Leu Arg Ser 
    370                 375                 380                 


Lys Val Leu Arg Lys Ile Glu Glu Leu Arg Thr Lys Val Lys Ser Leu 
385                 390                 395                 400 


Ser Ser Gly Ile Pro Asp Glu Phe Ile Cys Pro Ile Thr Arg Glu Leu 
                405                 410                 415     


Met Lys Asp Pro Val Ile Ala Ser Asp Gly Tyr Ser Tyr Glu Lys Glu 
            420                 425                 430         


Ala Met Glu Asn Trp Ile Ser Lys Lys Lys Arg Thr Ser Pro Met Thr 
        435                 440                 445             


Asn Leu Val Leu Pro Ser Ala Val Leu Thr Pro Asn Arg Thr Leu Lys 
    450                 455                 460                 


Met Ala Ile Asn Arg Trp Leu Glu Thr His Gln Lys 
465                 470                 475     


<210>  647
<211>  8145
<212>  DNA
<213>  Homosapiens

<400>  647
acttggttca tgaagccttc gcctagaagt gaagctgctg aacaaacctt gagaagaatc     60

atctcctgct tcaatctgct gctggatagg aactaatcag agagagagag gcggaagacg    120

gagaaggagg gagtcgaagg ctttcccgat cacaaatctc acctccacta caactctctt    180

tatacttttc ttgcagaaat aataatagaa ataaggaggt ggtggggttt ccaaaaatct    240

taaccttcaa ccatctgggg aaaaggcaaa aatcccatct accgcaactc tcagttcgag    300

agtaaaggtt tcccaacagt gatgtcacaa gattgaccac attgatcaca atatggagtc    360

tggagaacgg ttaccatcct cagcagcctc ctctactaca ccaacttcat cttcgacacc    420

ttctgtggct tcagtagttt caaaaggtgg cctttccact ggagttgctt cacttagctc    480

tacaatcaac ccatgtggac atttattcag aacagctggg gatcaaccgt ttaacctgtc    540

cacagtgtcg agtgccttcc caatggtcag ccacccagtc tttggtctac attcagccag    600

ctcagggcat tcagaatttg gtggtttggg gacacttggt acacccacag ccttagccgc    660

acatccccaa ctagcatctt ttccaggtgc agaatggtgg cgaacaactg atgctcatac    720

tcgtacagga gcaaccttct ttccaccatt actgggaatt ccaccactat ttgctccccc    780

agcccagaat catgattctt cttcattcca ttcaaggact tcgggaaaaa gtaatcgaaa    840

tggtcccgaa aaaggtgtaa atgggtcaat aaatggaagt aatacatcat ctgtaattgg    900

tatcaacaca tctgtactat ccactactgc ttcaagttcc atgggacaaa ctaaaagtac    960

aagctcaggt ggaggaaatc gaaaatgtaa tcaggaacaa agcaaaaacc agcctttgga   1020

tgctagagtt gacaaaatca aagataagaa accaaggaag aaagcaatgg aaagttctag   1080

caacagtgat agtgattcag gcacatcatc agacacctca agtgaaggca ttagtagcag   1140

tgattcagat gatctagaag aagatgaaga agaagaagat caaagtattg aagaaagtga   1200

agatgatgat tctgattcag agagtgaagc acaacataaa agtaacaacc aggtgctatt   1260

acatggtatt tcagacccaa aagcagatgg acagaaagca actgaaaaag cccaggaaaa   1320

aagaatacac cagccattac ctcttgcgtc tgaatcccag actcactcat tccaatccca   1380

gcagaagcag cctcaggttt tgtcacagca gcttccattt attttccaaa gctctcaggc   1440

aaaggaggaa tctgtgaaca aacacaccag tgtaatacag tctacgggat tggtgtccaa   1500

tgtgaaacct ttatctttgg taaatcaagc caaaaaggaa acttacatga aactcatagt   1560

tccttctcct gatgttctta aagcagggaa taaaaatacc tctgaagaat ctagtttatt   1620

gaccagtgaa ttgagatcca aacgggaaca atataaacag gcattcccat cacagttaaa   1680

gaaacaagag tcatcgaaga gcctgaagaa ggttattgca gctttgtcaa atccaaaagc   1740

aacctctagt tcaccagcac atccaaaaca aacattagaa aacaaccacc caaatccatt   1800

cttgacaaat gcacttttag gtaatcacca accaaatgga gttattcaaa gtgtcattca   1860

agaagctcct ctagcactta ctaccaaaac taaaatgcag agcaagatta atgaaaacat   1920

tgctgctgca agtagcaccc ctttttcctc acctgtaaat ctgagtacaa gtgggagaag   1980

aacccctggc aatcagacac ctgtaatgcc ctctgcctct cccatcctgc atagtcaagg   2040

gaaggaaaaa gcagttagca ataatgtaaa cccagtaaaa acacagcatc actcccatcc   2100

tgcaaaatct ttagtggaac aattcagagg aacagattca gacattccca gtagtaaaga   2160

ttctgaagat tcaaatgagg atgaagagga agatgatgaa gaagaagatg aggaagatga   2220

tgaagatgat gaatctgatg acagccaatc agaatcagat agtaattcag aatcagatac   2280

agaaggatca gaagaagaag atgatgatga taaagaccaa gatgaatcag atagtgatac   2340

tgaaggagag aaaacttcaa tgaaactgaa taaaacaact tcctctgtca aaagcccttc   2400

catgagtctc acaggtcact caacacctcg taacctccac atagcaaaag ccccaggctc   2460

tgctcctgct gccttatgtt ctgaatccca gtcacctgct tttcttggta catcttcttc   2520

cacacttact tcaagcccac actctggcac ttccaaaaga agaagagtaa cagatgaacg   2580

tgaactgcgt attccattgg aatatggctg gcagagagag acaagaataa gaaactttgg   2640

agggcgcctt caaggagaag tagcatatta tgctccatgt ggaaagaaac ttaggcagta   2700

ccctgaagta ataaagtatc tcagcagaaa tggaataatg gatatctcaa gggacaattt   2760

cagcttcagt gcaaaaataa gagtgggtga cttctatgaa gccagagatg gaccgcaggg   2820

aatgcagtgg tgtcttttga aagaagagga tgtcattcct cgtatcaggg caatggaagg   2880

tcgtagagga agaccaccaa atccagatag acaacgagca agagaggaat ccaggatgag   2940

acgtcggaaa ggtcgacctc caaatgttgg caatgctgaa ttcctagata acgcagatgc   3000

aaagttgcta agaaaactgc aagctcaaga aatagccagg caagcagcac aaataaagct   3060

tttgagaaaa cttcaaaagc aggaacaggc tcgggttgct aaagaagcca aaaaacaaca   3120

agcaataatg gctgctgagg agaagcggaa gcaaaaagaa cagataaaga ttatgaaaca   3180

gcaggaaaaa attaagagaa tacagcaaat cagaatggaa aaagaacttc gagctcagca   3240

aattctagag gctaaaaaga aaaagaagga agaagcggca aatgccaaat tattggaggc   3300

cgagaaacga ataaaggaaa aagaaatgag aagacaacaa gctgttcttc tgaaacatca   3360

ggaacgagag cgaaggcgac aacacatgat gcttatgaaa gctatggaag ctcgtaaaaa   3420

agcagaagaa aaagagcggt tgaaacaaga aaaacgtgat gagaaaagat taaataaaga   3480

gcgtaaacta gagcagcgaa gattagaatt agaaatggca aaggaactaa agaagcctaa   3540

tgaagacatg tgcttagcag accaaaagcc tttgccagag ttgcctcgta ttccaggact   3600

tgttctctct ggaagtacat tttcagactg tctcatggtg gtgcagttct tacgaaactt   3660

tggtaaagtt ttgggctttg atgtgaatat tgatgttcca aacctgagtg ttcttcaaga   3720

gggattgcta aatatagggg acagcatggg tgaagtacaa gacttgcttg tgaggctcct   3780

ctcagctgct gtatgtgatc caggtctaat aacaggatac aaggctaaaa cagctcttgg   3840

agaacatttg ctgaatgttg gtgtgaatcg agacaatgtt tccgagattt tacagatatt   3900

tatggaagcc cactgtggac aaactgagct tactgaaagt ctgaagacca aagcttttca   3960

ggctcacact ccagcacaga aagcttcagt cctggctttc ctgatcaatg aactggcatg   4020

cagcaagagt gtggtcagtg aaatcgacaa gaacattgat tatatgtcaa acttgaggag   4080

agataaatgg gtggtagaag gtaaactccg caagctcaga atcattcatg ctaagaaaac   4140

aggcaaaaga gacacttcag gtggcattga tctgggagaa gagcagcatc ccttgggcac   4200

acccactcca ggacgcaagc gaagaaggaa gggaggagac agtgattatg acgatgatga   4260

tgacgatgac agtgatgacc aaggggatga agatgatgag gatgaagaag ataaagaaga   4320

caaaaaagga aaaaagactg atatctgtga agatgaggat gaaggtgacc aagcagcaag   4380

tgttgaagag ctggaaaaac agattgaaaa actgagtaaa caacagagtc agtacagaag   4440

gaagctcttt gatgcgtctc actcattgcg ttcagtgatg tttggccaag atcgttacag   4500

acgccggtac tggattcttc cccaatgtgg ggggattttt gtagaaggca tggagagtgg   4560

tgaaggacta gaagaaattg caaaagaaag agaaaaactg aaaaaggcag aaagtgtcca   4620

gatcaaagaa gaaatgtttg agacttctgg ggacagttta aattgttcaa atacagatca   4680

ctgtgaacaa aaggaagatc ttaaagaaaa agataacaca aatctattcc ttcagaaacc   4740

tggctctttt tccaaattaa gcaagctttt ggaagtagct aagatgcctc ctgagtcaga   4800

ggttatgacc cccaaaccaa atgctggtgc aaatgggtgc acgttgtctt atcagaacag   4860

tggaaaacat tcactgggca gcgttcagtc aacagcaacg caaagcaatg tggaaaaggc   4920

agactctaat aatctgttta atactggttc aagtggtcca gggaagttct acagtcctct   4980

ccccaatgac cagttactaa aaacgctgac tgaaaagaat agacaatggt ttagtctttt   5040

gccacgaaca ccctgtgatg acacttcact tactcatgcc gatatgtcaa ctgcttcttt   5100

ggtgactcct cagtctcagc caccatctaa gtcaccttca cctaccccag ctcctcttgg   5160

atcttctgct cagaatcctg ttggcttaaa tccatttgct ttatcacctc ttcaggtgaa   5220

aggtggagta tctatgatgg gacttcagtt ttgtggatgg cccactggtg tggttacttc   5280

taatattcca tttacatcat ctgtacctag tctaggatcg gggttagggt tatcagaagg   5340

aaatggtaat tcattcttga cttccaatgt tgcttcaagt aaaagtgaat ctccagtacc   5400

acagaatgaa aaggccactt cagctcaacc tgcagctgtt gaagtagcaa aaccagtaga   5460

ttttcctagt ccaaaaccta ttccagaaga aatgcagttt ggttggtgga gaattattga   5520

cccagaggac ctaaaagctt tgctcaaagt gctgcatctc agaggaataa gagaaaaggc   5580

attacaaaaa caaattcaga aacatttgga ttatattact caagcctgcc tcaagaataa   5640

ggatgttgct attattgaac tgaatgaaaa tgaagaaaac caagtaactc gagatattgt   5700

ggagaactgg tcagtagaag aacaagcaat ggaaatggat ttgagtgtcc ttcaacaggt   5760

agaagatcta gaaaggagag ttgcatcagc aagtttgcaa gtgaagggtt ggatgtgtcc   5820

agagcctgca tcagaaaggg aggacttggt atattttgaa cataaatcat ttactaaatt   5880

gtgcaaggag catgatggag aatttactgg cgaagacgaa agcagtgcac atgcactaga   5940

acggaagagt gacaaccccc tagatatagc tgtaaccagg ctggctgatt tggagcggaa   6000

cattgaaaga agaattgaag aggatattgc tccagggctc agggtatgga gaagggcatt   6060

atcagaagct cgcagtgctg cacaggtagc tctgtgcatt cagcaattac agaaatcaat   6120

agcatgggaa aaatcaatta tgaaagttta ctgccaaatc tgtcgaaagg gagataatga   6180

agaactgctt cttctttgtg atggctgtga caaaggctgt catacctact gccatagacc   6240

caagattaca acaatcccag atggagactg gttttgtcca gcttgcattg ctaaggcaag   6300

tggtcaaact ctaaaaatca aaaaacttca tgtcaaagga aaaaagacta atgagtcaaa   6360

gaaaggcaag aaggtaactt taacaggaga tactgaagat gaagactctg catctacaag   6420

tagttcacta aaaagaggaa acaaagacct caagaaaaga aaaatggagg aaaacacttc   6480

tattaacttg tcaaaacaag aaagttttac ttcagttaag aaacctaaaa gagatgactc   6540

caaggaccta gctctttgca gtatgattct gactgaaatg gaaactcatg aggatgcatg   6600

gccttttcta cttcctgtaa acttgaaact tgttcctggt tataagaaag ttattaagaa   6660

gcctatggat ttttccacaa ttagagagaa actaagtagt ggacagtatc caaaccttga   6720

aacctttgct ctagatgtca ggcttgtttt tgacaactgt gaaacattta atgaagatga   6780

ttctgatata ggcagagctg gccacaatat gaggaagtat tttgaaaaaa agtggacaga   6840

tactttcaaa gtgagctgaa gttataataa tctctttatt tttttccttc taaacaagga   6900

caaatgagac cagcaatgtg aactgtattt acataaacgt gcaaggcaca tacataatga   6960

ctttcttttt ccttaagtat aaaaaaaaag tatcagaaga atgataccat ttttaaaggc   7020

ttcattccta caacaaccaa ggccctcggt tattggtttg tgtgatttat cagctaattt   7080

aggtagaaca gggaagcaca cccaaagaat tttcaaagga aagggtgtta tagtgcaata   7140

gcaattaaaa tatatcaaat cgcactgaat actcaacacc agagctctaa tgtgggaaat   7200

ggttctcctt tccctctcaa taaatatcta tttttcattt ttttactttg tagtttattt   7260

tttagtgaat gtatttaatt ttatgaatta tttatgatta aaccacatcc agaatcttcg   7320

ttttctgtga aaaggaagaa ctagaaaatt gctttaaatc ttgaaaatac aaggaatgtt   7380

ttaaaatata aaacaaagcc aagttaaact gtttacactg atgtgctata aaagcaccaa   7440

aaagaaactt tactgtagag ttacaagtac atttatatat atatgttgct gcatcacttg   7500

tgtagttaaa ttgtatttca aaacagtgaa aaaattgaca tgtatatact gttcattctt   7560

gtttatatta agtcttgttt taaatatgta ttatgtgtat atattgtttg cagacattat   7620

tgttcatgcc ttagaggatt gtagcatttt attttcgtct gaaggtaatg atagctatac   7680

agtctgtaca gtaattatcc tctaccaaca ctgtggcgtc tccttaatct tggtagtgcc   7740

tgcctttgaa acagggtgta ggggatatta gttttccatt tttctatttt gttatataat   7800

tttaagccac cagggcctaa attaaagtat aatcatttgt atccatgtgg aataaaattg   7860

tgacaatttc ctacgcacac agtatttttt catagaaaca tttccctccc atttgccttg   7920

cctcagaaat aaatttaaaa gacgtttgta accactgtgt tttatctact gtgtgttgtg   7980

gtggcctgtt ggaggcaaat agatcagatt ttttttgtac ctacgtaaga gtacttgaag   8040

ttttatttaa aataaaatgt tgtggaaaag gtagcattct ttttttagga gtgttatttt   8100

tcactatgtg tggcacggat acaataaaag acttttacaa actaa                   8145


<210>  648
<211>  2168
<212>  PRT
<213>  Homosapiens

<400>  648

Met Glu Ser Gly Glu Arg Leu Pro Ser Ser Ala Ala Ser Ser Thr Thr 
1               5                   10                  15      


Pro Thr Ser Ser Ser Thr Pro Ser Val Ala Ser Val Val Ser Lys Gly 
            20                  25                  30          


Gly Leu Ser Thr Gly Val Ala Ser Leu Ser Ser Thr Ile Asn Pro Cys 
        35                  40                  45              


Gly His Leu Phe Arg Thr Ala Gly Asp Gln Pro Phe Asn Leu Ser Thr 
    50                  55                  60                  


Val Ser Ser Ala Phe Pro Met Val Ser His Pro Val Phe Gly Leu His 
65                  70                  75                  80  


Ser Ala Ser Ser Gly His Ser Glu Phe Gly Gly Leu Gly Thr Leu Gly 
                85                  90                  95      


Thr Pro Thr Ala Leu Ala Ala His Pro Gln Leu Ala Ser Phe Pro Gly 
            100                 105                 110         


Ala Glu Trp Trp Arg Thr Thr Asp Ala His Thr Arg Thr Gly Ala Thr 
        115                 120                 125             


Phe Phe Pro Pro Leu Leu Gly Ile Pro Pro Leu Phe Ala Pro Pro Ala 
    130                 135                 140                 


Gln Asn His Asp Ser Ser Ser Phe His Ser Arg Thr Ser Gly Lys Ser 
145                 150                 155                 160 


Asn Arg Asn Gly Pro Glu Lys Gly Val Asn Gly Ser Ile Asn Gly Ser 
                165                 170                 175     


Asn Thr Ser Ser Val Ile Gly Ile Asn Thr Ser Val Leu Ser Thr Thr 
            180                 185                 190         


Ala Ser Ser Ser Met Gly Gln Thr Lys Ser Thr Ser Ser Gly Gly Gly 
        195                 200                 205             


Asn Arg Lys Cys Asn Gln Glu Gln Ser Lys Asn Gln Pro Leu Asp Ala 
    210                 215                 220                 


Arg Val Asp Lys Ile Lys Asp Lys Lys Pro Arg Lys Lys Ala Met Glu 
225                 230                 235                 240 


Ser Ser Ser Asn Ser Asp Ser Asp Ser Gly Thr Ser Ser Asp Thr Ser 
                245                 250                 255     


Ser Glu Gly Ile Ser Ser Ser Asp Ser Asp Asp Leu Glu Glu Asp Glu 
            260                 265                 270         


Glu Glu Glu Asp Gln Ser Ile Glu Glu Ser Glu Asp Asp Asp Ser Asp 
        275                 280                 285             


Ser Glu Ser Glu Ala Gln His Lys Ser Asn Asn Gln Val Leu Leu His 
    290                 295                 300                 


Gly Ile Ser Asp Pro Lys Ala Asp Gly Gln Lys Ala Thr Glu Lys Ala 
305                 310                 315                 320 


Gln Glu Lys Arg Ile His Gln Pro Leu Pro Leu Ala Ser Glu Ser Gln 
                325                 330                 335     


Thr His Ser Phe Gln Ser Gln Gln Lys Gln Pro Gln Val Leu Ser Gln 
            340                 345                 350         


Gln Leu Pro Phe Ile Phe Gln Ser Ser Gln Ala Lys Glu Glu Ser Val 
        355                 360                 365             


Asn Lys His Thr Ser Val Ile Gln Ser Thr Gly Leu Val Ser Asn Val 
    370                 375                 380                 


Lys Pro Leu Ser Leu Val Asn Gln Ala Lys Lys Glu Thr Tyr Met Lys 
385                 390                 395                 400 


Leu Ile Val Pro Ser Pro Asp Val Leu Lys Ala Gly Asn Lys Asn Thr 
                405                 410                 415     


Ser Glu Glu Ser Ser Leu Leu Thr Ser Glu Leu Arg Ser Lys Arg Glu 
            420                 425                 430         


Gln Tyr Lys Gln Ala Phe Pro Ser Gln Leu Lys Lys Gln Glu Ser Ser 
        435                 440                 445             


Lys Ser Leu Lys Lys Val Ile Ala Ala Leu Ser Asn Pro Lys Ala Thr 
    450                 455                 460                 


Ser Ser Ser Pro Ala His Pro Lys Gln Thr Leu Glu Asn Asn His Pro 
465                 470                 475                 480 


Asn Pro Phe Leu Thr Asn Ala Leu Leu Gly Asn His Gln Pro Asn Gly 
                485                 490                 495     


Val Ile Gln Ser Val Ile Gln Glu Ala Pro Leu Ala Leu Thr Thr Lys 
            500                 505                 510         


Thr Lys Met Gln Ser Lys Ile Asn Glu Asn Ile Ala Ala Ala Ser Ser 
        515                 520                 525             


Thr Pro Phe Ser Ser Pro Val Asn Leu Ser Thr Ser Gly Arg Arg Thr 
    530                 535                 540                 


Pro Gly Asn Gln Thr Pro Val Met Pro Ser Ala Ser Pro Ile Leu His 
545                 550                 555                 560 


Ser Gln Gly Lys Glu Lys Ala Val Ser Asn Asn Val Asn Pro Val Lys 
                565                 570                 575     


Thr Gln His His Ser His Pro Ala Lys Ser Leu Val Glu Gln Phe Arg 
            580                 585                 590         


Gly Thr Asp Ser Asp Ile Pro Ser Ser Lys Asp Ser Glu Asp Ser Asn 
        595                 600                 605             


Glu Asp Glu Glu Glu Asp Asp Glu Glu Glu Asp Glu Glu Asp Asp Glu 
    610                 615                 620                 


Asp Asp Glu Ser Asp Asp Ser Gln Ser Glu Ser Asp Ser Asn Ser Glu 
625                 630                 635                 640 


Ser Asp Thr Glu Gly Ser Glu Glu Glu Asp Asp Asp Asp Lys Asp Gln 
                645                 650                 655     


Asp Glu Ser Asp Ser Asp Thr Glu Gly Glu Lys Thr Ser Met Lys Leu 
            660                 665                 670         


Asn Lys Thr Thr Ser Ser Val Lys Ser Pro Ser Met Ser Leu Thr Gly 
        675                 680                 685             


His Ser Thr Pro Arg Asn Leu His Ile Ala Lys Ala Pro Gly Ser Ala 
    690                 695                 700                 


Pro Ala Ala Leu Cys Ser Glu Ser Gln Ser Pro Ala Phe Leu Gly Thr 
705                 710                 715                 720 


Ser Ser Ser Thr Leu Thr Ser Ser Pro His Ser Gly Thr Ser Lys Arg 
                725                 730                 735     


Arg Arg Val Thr Asp Glu Arg Glu Leu Arg Ile Pro Leu Glu Tyr Gly 
            740                 745                 750         


Trp Gln Arg Glu Thr Arg Ile Arg Asn Phe Gly Gly Arg Leu Gln Gly 
        755                 760                 765             


Glu Val Ala Tyr Tyr Ala Pro Cys Gly Lys Lys Leu Arg Gln Tyr Pro 
    770                 775                 780                 


Glu Val Ile Lys Tyr Leu Ser Arg Asn Gly Ile Met Asp Ile Ser Arg 
785                 790                 795                 800 


Asp Asn Phe Ser Phe Ser Ala Lys Ile Arg Val Gly Asp Phe Tyr Glu 
                805                 810                 815     


Ala Arg Asp Gly Pro Gln Gly Met Gln Trp Cys Leu Leu Lys Glu Glu 
            820                 825                 830         


Asp Val Ile Pro Arg Ile Arg Ala Met Glu Gly Arg Arg Gly Arg Pro 
        835                 840                 845             


Pro Asn Pro Asp Arg Gln Arg Ala Arg Glu Glu Ser Arg Met Arg Arg 
    850                 855                 860                 


Arg Lys Gly Arg Pro Pro Asn Val Gly Asn Ala Glu Phe Leu Asp Asn 
865                 870                 875                 880 


Ala Asp Ala Lys Leu Leu Arg Lys Leu Gln Ala Gln Glu Ile Ala Arg 
                885                 890                 895     


Gln Ala Ala Gln Ile Lys Leu Leu Arg Lys Leu Gln Lys Gln Glu Gln 
            900                 905                 910         


Ala Arg Val Ala Lys Glu Ala Lys Lys Gln Gln Ala Ile Met Ala Ala 
        915                 920                 925             


Glu Glu Lys Arg Lys Gln Lys Glu Gln Ile Lys Ile Met Lys Gln Gln 
    930                 935                 940                 


Glu Lys Ile Lys Arg Ile Gln Gln Ile Arg Met Glu Lys Glu Leu Arg 
945                 950                 955                 960 


Ala Gln Gln Ile Leu Glu Ala Lys Lys Lys Lys Lys Glu Glu Ala Ala 
                965                 970                 975     


Asn Ala Lys Leu Leu Glu Ala Glu Lys Arg Ile Lys Glu Lys Glu Met 
            980                 985                 990         


Arg Arg Gln Gln Ala Val Leu Leu  Lys His Gln Glu Arg  Glu Arg Arg 
        995                 1000                 1005             


Arg Gln  His Met Met Leu Met  Lys Ala Met Glu Ala  Arg Lys Lys 
    1010                 1015                 1020             


Ala Glu  Glu Lys Glu Arg Leu  Lys Gln Glu Lys Arg  Asp Glu Lys 
    1025                 1030                 1035             


Arg Leu  Asn Lys Glu Arg Lys  Leu Glu Gln Arg Arg  Leu Glu Leu 
    1040                 1045                 1050             


Glu Met  Ala Lys Glu Leu Lys  Lys Pro Asn Glu Asp  Met Cys Leu 
    1055                 1060                 1065             


Ala Asp  Gln Lys Pro Leu Pro  Glu Leu Pro Arg Ile  Pro Gly Leu 
    1070                 1075                 1080             


Val Leu  Ser Gly Ser Thr Phe  Ser Asp Cys Leu Met  Val Val Gln 
    1085                 1090                 1095             


Phe Leu  Arg Asn Phe Gly Lys  Val Leu Gly Phe Asp  Val Asn Ile 
    1100                 1105                 1110             


Asp Val  Pro Asn Leu Ser Val  Leu Gln Glu Gly Leu  Leu Asn Ile 
    1115                 1120                 1125             


Gly Asp  Ser Met Gly Glu Val  Gln Asp Leu Leu Val  Arg Leu Leu 
    1130                 1135                 1140             


Ser Ala  Ala Val Cys Asp Pro  Gly Leu Ile Thr Gly  Tyr Lys Ala 
    1145                 1150                 1155             


Lys Thr  Ala Leu Gly Glu His  Leu Leu Asn Val Gly  Val Asn Arg 
    1160                 1165                 1170             


Asp Asn  Val Ser Glu Ile Leu  Gln Ile Phe Met Glu  Ala His Cys 
    1175                 1180                 1185             


Gly Gln  Thr Glu Leu Thr Glu  Ser Leu Lys Thr Lys  Ala Phe Gln 
    1190                 1195                 1200             


Ala His  Thr Pro Ala Gln Lys  Ala Ser Val Leu Ala  Phe Leu Ile 
    1205                 1210                 1215             


Asn Glu  Leu Ala Cys Ser Lys  Ser Val Val Ser Glu  Ile Asp Lys 
    1220                 1225                 1230             


Asn Ile  Asp Tyr Met Ser Asn  Leu Arg Arg Asp Lys  Trp Val Val 
    1235                 1240                 1245             


Glu Gly  Lys Leu Arg Lys Leu  Arg Ile Ile His Ala  Lys Lys Thr 
    1250                 1255                 1260             


Gly Lys  Arg Asp Thr Ser Gly  Gly Ile Asp Leu Gly  Glu Glu Gln 
    1265                 1270                 1275             


His Pro  Leu Gly Thr Pro Thr  Pro Gly Arg Lys Arg  Arg Arg Lys 
    1280                 1285                 1290             


Gly Gly  Asp Ser Asp Tyr Asp  Asp Asp Asp Asp Asp  Asp Ser Asp 
    1295                 1300                 1305             


Asp Gln  Gly Asp Glu Asp Asp  Glu Asp Glu Glu Asp  Lys Glu Asp 
    1310                 1315                 1320             


Lys Lys  Gly Lys Lys Thr Asp  Ile Cys Glu Asp Glu  Asp Glu Gly 
    1325                 1330                 1335             


Asp Gln  Ala Ala Ser Val Glu  Glu Leu Glu Lys Gln  Ile Glu Lys 
    1340                 1345                 1350             


Leu Ser  Lys Gln Gln Ser Gln  Tyr Arg Arg Lys Leu  Phe Asp Ala 
    1355                 1360                 1365             


Ser His  Ser Leu Arg Ser Val  Met Phe Gly Gln Asp  Arg Tyr Arg 
    1370                 1375                 1380             


Arg Arg  Tyr Trp Ile Leu Pro  Gln Cys Gly Gly Ile  Phe Val Glu 
    1385                 1390                 1395             


Gly Met  Glu Ser Gly Glu Gly  Leu Glu Glu Ile Ala  Lys Glu Arg 
    1400                 1405                 1410             


Glu Lys  Leu Lys Lys Ala Glu  Ser Val Gln Ile Lys  Glu Glu Met 
    1415                 1420                 1425             


Phe Glu  Thr Ser Gly Asp Ser  Leu Asn Cys Ser Asn  Thr Asp His 
    1430                 1435                 1440             


Cys Glu  Gln Lys Glu Asp Leu  Lys Glu Lys Asp Asn  Thr Asn Leu 
    1445                 1450                 1455             


Phe Leu  Gln Lys Pro Gly Ser  Phe Ser Lys Leu Ser  Lys Leu Leu 
    1460                 1465                 1470             


Glu Val  Ala Lys Met Pro Pro  Glu Ser Glu Val Met  Thr Pro Lys 
    1475                 1480                 1485             


Pro Asn  Ala Gly Ala Asn Gly  Cys Thr Leu Ser Tyr  Gln Asn Ser 
    1490                 1495                 1500             


Gly Lys  His Ser Leu Gly Ser  Val Gln Ser Thr Ala  Thr Gln Ser 
    1505                 1510                 1515             


Asn Val  Glu Lys Ala Asp Ser  Asn Asn Leu Phe Asn  Thr Gly Ser 
    1520                 1525                 1530             


Ser Gly  Pro Gly Lys Phe Tyr  Ser Pro Leu Pro Asn  Asp Gln Leu 
    1535                 1540                 1545             


Leu Lys  Thr Leu Thr Glu Lys  Asn Arg Gln Trp Phe  Ser Leu Leu 
    1550                 1555                 1560             


Pro Arg  Thr Pro Cys Asp Asp  Thr Ser Leu Thr His  Ala Asp Met 
    1565                 1570                 1575             


Ser Thr  Ala Ser Leu Val Thr  Pro Gln Ser Gln Pro  Pro Ser Lys 
    1580                 1585                 1590             


Ser Pro  Ser Pro Thr Pro Ala  Pro Leu Gly Ser Ser  Ala Gln Asn 
    1595                 1600                 1605             


Pro Val  Gly Leu Asn Pro Phe  Ala Leu Ser Pro Leu  Gln Val Lys 
    1610                 1615                 1620             


Gly Gly  Val Ser Met Met Gly  Leu Gln Phe Cys Gly  Trp Pro Thr 
    1625                 1630                 1635             


Gly Val  Val Thr Ser Asn Ile  Pro Phe Thr Ser Ser  Val Pro Ser 
    1640                 1645                 1650             


Leu Gly  Ser Gly Leu Gly Leu  Ser Glu Gly Asn Gly  Asn Ser Phe 
    1655                 1660                 1665             


Leu Thr  Ser Asn Val Ala Ser  Ser Lys Ser Glu Ser  Pro Val Pro 
    1670                 1675                 1680             


Gln Asn  Glu Lys Ala Thr Ser  Ala Gln Pro Ala Ala  Val Glu Val 
    1685                 1690                 1695             


Ala Lys  Pro Val Asp Phe Pro  Ser Pro Lys Pro Ile  Pro Glu Glu 
    1700                 1705                 1710             


Met Gln  Phe Gly Trp Trp Arg  Ile Ile Asp Pro Glu  Asp Leu Lys 
    1715                 1720                 1725             


Ala Leu  Leu Lys Val Leu His  Leu Arg Gly Ile Arg  Glu Lys Ala 
    1730                 1735                 1740             


Leu Gln  Lys Gln Ile Gln Lys  His Leu Asp Tyr Ile  Thr Gln Ala 
    1745                 1750                 1755             


Cys Leu  Lys Asn Lys Asp Val  Ala Ile Ile Glu Leu  Asn Glu Asn 
    1760                 1765                 1770             


Glu Glu  Asn Gln Val Thr Arg  Asp Ile Val Glu Asn  Trp Ser Val 
    1775                 1780                 1785             


Glu Glu  Gln Ala Met Glu Met  Asp Leu Ser Val Leu  Gln Gln Val 
    1790                 1795                 1800             


Glu Asp  Leu Glu Arg Arg Val  Ala Ser Ala Ser Leu  Gln Val Lys 
    1805                 1810                 1815             


Gly Trp  Met Cys Pro Glu Pro  Ala Ser Glu Arg Glu  Asp Leu Val 
    1820                 1825                 1830             


Tyr Phe  Glu His Lys Ser Phe  Thr Lys Leu Cys Lys  Glu His Asp 
    1835                 1840                 1845             


Gly Glu  Phe Thr Gly Glu Asp  Glu Ser Ser Ala His  Ala Leu Glu 
    1850                 1855                 1860             


Arg Lys  Ser Asp Asn Pro Leu  Asp Ile Ala Val Thr  Arg Leu Ala 
    1865                 1870                 1875             


Asp Leu  Glu Arg Asn Ile Glu  Arg Arg Ile Glu Glu  Asp Ile Ala 
    1880                 1885                 1890             


Pro Gly  Leu Arg Val Trp Arg  Arg Ala Leu Ser Glu  Ala Arg Ser 
    1895                 1900                 1905             


Ala Ala  Gln Val Ala Leu Cys  Ile Gln Gln Leu Gln  Lys Ser Ile 
    1910                 1915                 1920             


Ala Trp  Glu Lys Ser Ile Met  Lys Val Tyr Cys Gln  Ile Cys Arg 
    1925                 1930                 1935             


Lys Gly  Asp Asn Glu Glu Leu  Leu Leu Leu Cys Asp  Gly Cys Asp 
    1940                 1945                 1950             


Lys Gly  Cys His Thr Tyr Cys  His Arg Pro Lys Ile  Thr Thr Ile 
    1955                 1960                 1965             


Pro Asp  Gly Asp Trp Phe Cys  Pro Ala Cys Ile Ala  Lys Ala Ser 
    1970                 1975                 1980             


Gly Gln  Thr Leu Lys Ile Lys  Lys Leu His Val Lys  Gly Lys Lys 
    1985                 1990                 1995             


Thr Asn  Glu Ser Lys Lys Gly  Lys Lys Val Thr Leu  Thr Gly Asp 
    2000                 2005                 2010             


Thr Glu  Asp Glu Asp Ser Ala  Ser Thr Ser Ser Ser  Leu Lys Arg 
    2015                 2020                 2025             


Gly Asn  Lys Asp Leu Lys Lys  Arg Lys Met Glu Glu  Asn Thr Ser 
    2030                 2035                 2040             


Ile Asn  Leu Ser Lys Gln Glu  Ser Phe Thr Ser Val  Lys Lys Pro 
    2045                 2050                 2055             


Lys Arg  Asp Asp Ser Lys Asp  Leu Ala Leu Cys Ser  Met Ile Leu 
    2060                 2065                 2070             


Thr Glu  Met Glu Thr His Glu  Asp Ala Trp Pro Phe  Leu Leu Pro 
    2075                 2080                 2085             


Val Asn  Leu Lys Leu Val Pro  Gly Tyr Lys Lys Val  Ile Lys Lys 
    2090                 2095                 2100             


Pro Met  Asp Phe Ser Thr Ile  Arg Glu Lys Leu Ser  Ser Gly Gln 
    2105                 2110                 2115             


Tyr Pro  Asn Leu Glu Thr Phe  Ala Leu Asp Val Arg  Leu Val Phe 
    2120                 2125                 2130             


Asp Asn  Cys Glu Thr Phe Asn  Glu Asp Asp Ser Asp  Ile Gly Arg 
    2135                 2140                 2145             


Ala Gly  His Asn Met Arg Lys  Tyr Phe Glu Lys Lys  Trp Thr Asp 
    2150                 2155                 2160             


Thr Phe  Lys Val Ser 
    2165             


<210>  649
<211>  3484
<212>  DNA
<213>  Homosapiens

<400>  649
ggtggctggt tctgcgccgg atccgggaga ggggcgggcg ccattgtgct tcgctgccga     60

ctgcatttcc tcagtcacgg gcctagaact ccaaggagaa aggcggcgaa aaatctttaa    120

gaatggagtc taaaccttca aggattccaa gaagaatttc tgttcaacct tccagctcct    180

taagtgctag gatgatgtct ggaagcagag gaagtagttt aaatgatacc tatcactcaa    240

gagactcttc atttagattg gattctgaat atcagtctac atcagcatca gcatctgcgt    300

caccatttca atctgcatgg tatagtgaat ctgagataac tcagggagca cgctcaagat    360

cgcagaacca gcaacgggat catgattcaa aaagacctaa actttcctgt acaaactgta    420

ctacctcagc tgggagaaat gttggaaatg gtttaaacac attatcagat tcatcttgga    480

ggcatagtca agttcctaga tcttcatcaa tggtacttgg atcatttgga acagacttaa    540

tgagagagag gagagatttg gagagaagaa cagattcctc tattagtaat cttatggatt    600

atagtcaccg aagtggtgat ttcacaactt catcatatgt tcaagacaga gttccttcat    660

attcacaagg agcaagacca aaagaaaact caatgagcac tttacagttg aatacatcat    720

ccacaaacca ccaattgcct tctgaacatc agaccatact aagttctagg gactccagaa    780

attctttaag atcaaatttt tcttcaagag aatcagaatc ttcccgaagc aatacgcagc    840

ctggattttc ttacagttca agtagagatg aagccccaat cataagcaat tcagaaaggg    900

ttgtttcatc tcaaagacca tttcaagaat cttctgacaa tgaaggtagg cggacaacga    960

ggagattgct gtcacgcata gcttctagca tgtcatctac ttttttttca cgaagatcta   1020

gtcaggattc cttgaataca agatcattga attctgaaaa ttcttacgtt tctccaagaa   1080

tcttgacagc ttcacagtcc cgtagtaatg taccatcagc ttctgaagtt cccgataata   1140

gggcatctga agcttctcag ggatttcgat ttcttaggcg aagatggggt ttgtcatctc   1200

ttagccacaa tcatagctct gagtcagatt cagaaaattt taaccaagaa tctgaaggta   1260

gaaatacagg accatggtta tcttcctcac ttagaaatag atgcacacct ttgttctcta   1320

gaaggaggcg agagggaaga gatgaatctt caaggatacc tacctctgat acatcatcta   1380

gatctcatat ttttagaaga gaatcaaatg aagtggttca ccttgaagca cagaatgatc   1440

ctcttggagc tgctgccaac agaccacaag catctgcagc atcaagcagt gccacaacag   1500

gtggctctac atcagattcg gctcaaggtg gaagaaatac aggaatatca gggattcttc   1560

ctggttcctt attccggttt gcagtccctc cagcacttgg gagtaatttg accgacaatg   1620

tcatgatcac agtagatatt attccttcag gttggaattc agctgatggt aaaagtgata   1680

aaactaaaag tgcgccttca agagatccag aaagattgca gaaaataaaa gagagcctcc   1740

ttttagagga ctcagaagaa gaagaaggtg acttatgtag aatttgtcaa atggcagctg   1800

catcatcatc taatttgctg atagagccat gcaagtgcac aggaagtttg cagtatgtcc   1860

accaagactg tatgaaaaag tggttacagg ccaaaattaa ctctggttct tcattagaag   1920

ctgtaaccac ctgtgaacta tgtaaagaga agttggagct taacctggag gattttgata   1980

ttcatgaact acatagagct catgcaaatg aacaagctga gtatgagttt atcagctctg   2040

gtctctacct agtggtgtta ttgcacttgt gcgaacaaag cttttctgat atgatgggaa   2100

atacaaatga accaagcaca cgtgtccgat ttattaacct tgcaagaact cttcaggcac   2160

atatggaaga tctcgaaact tcagaggatg attccgaaga agacggagac cataacagga   2220

catttgatat tgcctaactt catataagac agatggatga tctgtgaaca taagtgttta   2280

ttaaaaatgg caattaaata taaattactt ttgtggggga atgcctaata aatacattga   2340

ctatatataa aatgaatata tacatacaca tgtatgcctg tatatatata ttcattctcc   2400

agtgttgctg aattaaaatt ctgctggact ttttaacata gcaaatccga tgtttataaa   2460

ctggtaatca aaaaggtttt ttcttttagg tgagtgggaa agtattaccc ttgttttaaa   2520

tatctaagca atgcctatca accctttttt gtgttatgat tactgtagtc atatttatga   2580

aaaaaggttt gtgttttact cttgctagtg agaaaagtgg gacaaaatat acttttgaaa   2640

taaaatgcta tatggcacct aattattttt tcttttaaaa tgccttaagt tgcagtctca   2700

ttttgataat catttgcttc cagtgtttaa aaattaaaaa aagaatgggg agaaggttat   2760

gagaagagca ttattaagtt tccaaattta atttgaattc caaattcacc tagcaataaa   2820

atctaatttt taaaaagtat ataaatataa aatgtataaa tgatggatag atttttgtat   2880

tgatttgcaa aatgcagatt atatttgata ggctatagta tgtagatatt ccttttagga   2940

atattacagc tgtaaattat atgagacttg ccagtcaaat gctatttggt ttaaaaaaat   3000

tattgcaatc tcaagttaat ggaatatttt taaatcccac attcagagtt taaaacactg   3060

gttttcaatg tgttttttag tgttgtcact tgtttataga taaatatata aataacctgt   3120

ttggatcctg gtccttttta actgttcctt ggtaattctg agcatttatt tgatgactta   3180

atatttttca ctacctttgg agaacagatg aacattattc accatgaatg gatctatact   3240

gtgtggtcat gagttgtgta tacttccata acactgtatt tttcttctgt cagtaccctt   3300

aggatacact ttaaaacacc ttaaggtctg atgttatggc aacaaactac tttttcaaac   3360

ctaaatagga accatgtaat ttctcaaaag tgattgaaca gtttgcccac acttagtttg   3420

ttggtcttat gtaaaacatt ggctcaaaat aaagtacaca ctgatttaaa aaaaaaaaaa   3480

aaaa                                                                3484


<210>  650
<211>  704
<212>  PRT
<213>  Homosapiens

<400>  650

Met Glu Ser Lys Pro Ser Arg Ile Pro Arg Arg Ile Ser Val Gln Pro 
1               5                   10                  15      


Ser Ser Ser Leu Ser Ala Arg Met Met Ser Gly Ser Arg Gly Ser Ser 
            20                  25                  30          


Leu Asn Asp Thr Tyr His Ser Arg Asp Ser Ser Phe Arg Leu Asp Ser 
        35                  40                  45              


Glu Tyr Gln Ser Thr Ser Ala Ser Ala Ser Ala Ser Pro Phe Gln Ser 
    50                  55                  60                  


Ala Trp Tyr Ser Glu Ser Glu Ile Thr Gln Gly Ala Arg Ser Arg Ser 
65                  70                  75                  80  


Gln Asn Gln Gln Arg Asp His Asp Ser Lys Arg Pro Lys Leu Ser Cys 
                85                  90                  95      


Thr Asn Cys Thr Thr Ser Ala Gly Arg Asn Val Gly Asn Gly Leu Asn 
            100                 105                 110         


Thr Leu Ser Asp Ser Ser Trp Arg His Ser Gln Val Pro Arg Ser Ser 
        115                 120                 125             


Ser Met Val Leu Gly Ser Phe Gly Thr Asp Leu Met Arg Glu Arg Arg 
    130                 135                 140                 


Asp Leu Glu Arg Arg Thr Asp Ser Ser Ile Ser Asn Leu Met Asp Tyr 
145                 150                 155                 160 


Ser His Arg Ser Gly Asp Phe Thr Thr Ser Ser Tyr Val Gln Asp Arg 
                165                 170                 175     


Val Pro Ser Tyr Ser Gln Gly Ala Arg Pro Lys Glu Asn Ser Met Ser 
            180                 185                 190         


Thr Leu Gln Leu Asn Thr Ser Ser Thr Asn His Gln Leu Pro Ser Glu 
        195                 200                 205             


His Gln Thr Ile Leu Ser Ser Arg Asp Ser Arg Asn Ser Leu Arg Ser 
    210                 215                 220                 


Asn Phe Ser Ser Arg Glu Ser Glu Ser Ser Arg Ser Asn Thr Gln Pro 
225                 230                 235                 240 


Gly Phe Ser Tyr Ser Ser Ser Arg Asp Glu Ala Pro Ile Ile Ser Asn 
                245                 250                 255     


Ser Glu Arg Val Val Ser Ser Gln Arg Pro Phe Gln Glu Ser Ser Asp 
            260                 265                 270         


Asn Glu Gly Arg Arg Thr Thr Arg Arg Leu Leu Ser Arg Ile Ala Ser 
        275                 280                 285             


Ser Met Ser Ser Thr Phe Phe Ser Arg Arg Ser Ser Gln Asp Ser Leu 
    290                 295                 300                 


Asn Thr Arg Ser Leu Asn Ser Glu Asn Ser Tyr Val Ser Pro Arg Ile 
305                 310                 315                 320 


Leu Thr Ala Ser Gln Ser Arg Ser Asn Val Pro Ser Ala Ser Glu Val 
                325                 330                 335     


Pro Asp Asn Arg Ala Ser Glu Ala Ser Gln Gly Phe Arg Phe Leu Arg 
            340                 345                 350         


Arg Arg Trp Gly Leu Ser Ser Leu Ser His Asn His Ser Ser Glu Ser 
        355                 360                 365             


Asp Ser Glu Asn Phe Asn Gln Glu Ser Glu Gly Arg Asn Thr Gly Pro 
    370                 375                 380                 


Trp Leu Ser Ser Ser Leu Arg Asn Arg Cys Thr Pro Leu Phe Ser Arg 
385                 390                 395                 400 


Arg Arg Arg Glu Gly Arg Asp Glu Ser Ser Arg Ile Pro Thr Ser Asp 
                405                 410                 415     


Thr Ser Ser Arg Ser His Ile Phe Arg Arg Glu Ser Asn Glu Val Val 
            420                 425                 430         


His Leu Glu Ala Gln Asn Asp Pro Leu Gly Ala Ala Ala Asn Arg Pro 
        435                 440                 445             


Gln Ala Ser Ala Ala Ser Ser Ser Ala Thr Thr Gly Gly Ser Thr Ser 
    450                 455                 460                 


Asp Ser Ala Gln Gly Gly Arg Asn Thr Gly Ile Ser Gly Ile Leu Pro 
465                 470                 475                 480 


Gly Ser Leu Phe Arg Phe Ala Val Pro Pro Ala Leu Gly Ser Asn Leu 
                485                 490                 495     


Thr Asp Asn Val Met Ile Thr Val Asp Ile Ile Pro Ser Gly Trp Asn 
            500                 505                 510         


Ser Ala Asp Gly Lys Ser Asp Lys Thr Lys Ser Ala Pro Ser Arg Asp 
        515                 520                 525             


Pro Glu Arg Leu Gln Lys Ile Lys Glu Ser Leu Leu Leu Glu Asp Ser 
    530                 535                 540                 


Glu Glu Glu Glu Gly Asp Leu Cys Arg Ile Cys Gln Met Ala Ala Ala 
545                 550                 555                 560 


Ser Ser Ser Asn Leu Leu Ile Glu Pro Cys Lys Cys Thr Gly Ser Leu 
                565                 570                 575     


Gln Tyr Val His Gln Asp Cys Met Lys Lys Trp Leu Gln Ala Lys Ile 
            580                 585                 590         


Asn Ser Gly Ser Ser Leu Glu Ala Val Thr Thr Cys Glu Leu Cys Lys 
        595                 600                 605             


Glu Lys Leu Glu Leu Asn Leu Glu Asp Phe Asp Ile His Glu Leu His 
    610                 615                 620                 


Arg Ala His Ala Asn Glu Gln Ala Glu Tyr Glu Phe Ile Ser Ser Gly 
625                 630                 635                 640 


Leu Tyr Leu Val Val Leu Leu His Leu Cys Glu Gln Ser Phe Ser Asp 
                645                 650                 655     


Met Met Gly Asn Thr Asn Glu Pro Ser Thr Arg Val Arg Phe Ile Asn 
            660                 665                 670         


Leu Ala Arg Thr Leu Gln Ala His Met Glu Asp Leu Glu Thr Ser Glu 
        675                 680                 685             


Asp Asp Ser Glu Glu Asp Gly Asp His Asn Arg Thr Phe Asp Ile Ala 
    690                 695                 700                 


<210>  651
<211>  3740
<212>  DNA
<213>  Homosapiens

<400>  651
ctctccggcc gcgcagccgc tgccgcccac ccgcacccgc cgtcatgctc cgggccgcgc     60

tgcccgcgct cctgctgccg ttgctgggcc tcgccgctgc tgccgtcgcg gactgtcctt    120

catctacttg gattcagttc caagacagtt gttacatttt tctccaagaa gccatcaaag    180

tagaaagcat agaggatgtc agaaatcagt gtactgacca tggagcggac atgataagca    240

tacataatga agaagaaaat gcttttatac tggatacttt gaaaaagcaa tggaaaggcc    300

cagatgatat cctactaggc atgttttatg acacagatga tgcgagtttc aagtggtttg    360

ataattcaaa tatgacattt gataagtgga cagaccaaga tgatgatgag gatttagttg    420

acacctgtgc ttttctgcac atcaagacag gtgaatggaa aaaaggaaat tgtgaagttt    480

cttctgtgga aggaacacta tgcaaaacag ctatcccata caaaaggaaa tatttatcag    540

ataaccacat tttaatatca gcattggtga ttgctagcac ggtaattttg acagttttgg    600

gagcaatcat ttggttcctg tacaaaaaac attctgattc tcgtttcacc acagtttttt    660

caaccgcacc ccaatcacct tataatgaag actgtgtttt ggtagttgga gaagaaaatg    720

aatatcctgt tcaatttgac taagtttttg gtaatcttgc actaagacat caacaaatgc    780

cctggcagag ataacttggg aaagatttta atataaaact tgacattgga tattagagct    840

ttaatggtat tccttattcc agtaacattt ttatgtactc atctgctgtg aaaagtcttt    900

aggttcatta aaaaaacagg ttttagaaat gatcttagat ctaatatagt gattttaagc    960

atcccgtcaa aggcagaatc tgtcacttga atgaaggaaa gcttaaagcc caagcagata   1020

aaaataaaag cccagcctat ttgtcttgcc tgctgtatct tccctattta gttgacccac   1080

tttagtttat atgtttatta gtaaacatga aatggggaat aagtgatttt aagtacatcc   1140

catacattta aatatctttg ataattgtta tttttttggc agataattcc tctagaatgt   1200

gtatcttttt atgatttaga tgaagaaaat tttacaactt ttaacacccc acaccaattt   1260

tagtttcatt acttttacac acaccatttt atcacaaatg actcaagttt taatgaatgt   1320

ttataaatta tttgaaacaa aatatgatcg ctgtgtccag gatggcatag agaaagctgg   1380

caattaggtt aacacttaca tattatagtg cccctttaag gatttctctc ttgccaccat   1440

accttttgta ctttccccta tacaagatgt atctcattct cctcaagcat ttataaattt   1500

ttccttcaat gacatgaaaa ctgtgcaagc aaaaaccgaa gaaaaacact taagtacaac   1560

tgtagtgaca gtgatcaaag ttttcagtgc atttattgta cattttaaga aaaaggtgaa   1620

aatcatttgg ggagtaaaaa aatgaaaaag ctgaaacgag taattttcct caccatcaat   1680

aaaccaaaaa caggaaagat aaagaatgta taaatttcac gtaaattagt cacgtatcac   1740

ttatcaatgg ggatacgttc taagaaatgc atagttaggg aatcttgtgt gaaaatcagc   1800

ttgtatttac acaaacccag atggtagagc ctattttgtc ccaaacctac acagcatgtt   1860

actgtgctga atactgcaga caattgtaac acaatatttg tgtatctaaa tatagaaaag   1920

gtacagtaaa aatatggtct actaaggaaa cactgttcta tatgtggtcc attactgact   1980

gaagtatact gtctagaagt ctgaggctca aagaaaagta atccctcttc tgaatccaca   2040

ccccatcaat tatcttactt tcttctgggg agatagatag atatactatc tcactagctt   2100

gactaatggc aacaaagttc cagcttgtgt agtctctttt tattgaccac atgaatcgaa   2160

aacactcatc acaattaatg gcactatcat taatgagaca tgagtaacta aaaagtgata   2220

gaaaactatt acagtgcggc tacatggtac tgaaaatgca ggcattacac cagctgttac   2280

acaagcacaa gcatgctctg taagagcttt acatttctga gattttgtat agtgattgag   2340

atgtctattt tattattgat agactattac taatgtcaat attgaacact accctggaat   2400

tcctgcctgg ttttcctacc caaattgtac cactccttga agaactacag gcacagtaaa   2460

aaaatatggc gtattatgtg aactaaaaga gttctaaagg agttcttaaa ggagtggtag   2520

aatttgggta ggaaagtgat taagtccaac ttaaaaccaa cagtctcaaa cgtctacaac   2580

tacaatgtcc aatgagccac tagccacatg aggctattta agtaaattta gtttaaaatc   2640

cagttttcga attacattag ccacattgtc aagtgttcaa atcacaggtg gttagtggct   2700

actgtactgg gcaacataca ttatagaaca ttttcattat aggaagtttt attgggcagt   2760

gctgctctta aatcctacct tccactcaac tcccatacaa ctttcttttg tacattttga   2820

tactttctac ctaatggcag ctcttccaaa atagctgctt taaactctga tttaattttc   2880

aatatttggt ttcatttttc aacaggccaa gaggcctctg gtaatgaagt gctatatata   2940

tatatatatg acggagtctc actgtgctgc ccaggctaca gtgcagtggc tcgatcttgg   3000

ctctctccaa tctccgcctt gcaggttttc aagcaattct cctgcctcag cctccttagt   3060

agctgggacc acagacatct gtcaccacac ccagctaact ttttgtattt ttggtagaga   3120

cggggtttcg ccatattgac tgggctggtc tcaaactcct gacctcaagt gatccaccca   3180

ccttggtctc ccaaagtgct gggattacat gcgtgagcca ccacacttgg cctacatttt   3240

ttctttatat accagaacat ctataacagg caccttatct actcattagt gaagagataa   3300

ttggattaca caggcaggct tgtttactac atccagaatg tagaaactgc tttcttcaac   3360

atcttggttc tagctagtaa taacaatata attctttggc agatattcag aataacattt   3420

taaactacat tttcttagaa aattgcattc ttgtagtgag cagtgtatgg tctcttttgt   3480

tcagaattta aaactgataa ccaatgaaag ccttttctct tattcctcta ccgtcattta   3540

catgataatc tgaagctaat atgacaatat ttaaatacta agtggtacta gggaactaca   3600

agaatactgt aaagcttaag ccattgttat cactgtcatt tagcatttaa taacaaaact   3660

atacagaatt atgtgcatac caatgaatgt tttgtaccat ctagttaaat tttttaaata   3720

aagttttatg ggttaagcag                                               3740


<210>  652
<211>  232
<212>  PRT
<213>  Homosapiens

<400>  652

Met Leu Arg Ala Ala Leu Pro Ala Leu Leu Leu Pro Leu Leu Gly Leu 
1               5                   10                  15      


Ala Ala Ala Ala Val Ala Asp Cys Pro Ser Ser Thr Trp Ile Gln Phe 
            20                  25                  30          


Gln Asp Ser Cys Tyr Ile Phe Leu Gln Glu Ala Ile Lys Val Glu Ser 
        35                  40                  45              


Ile Glu Asp Val Arg Asn Gln Cys Thr Asp His Gly Ala Asp Met Ile 
    50                  55                  60                  


Ser Ile His Asn Glu Glu Glu Asn Ala Phe Ile Leu Asp Thr Leu Lys 
65                  70                  75                  80  


Lys Gln Trp Lys Gly Pro Asp Asp Ile Leu Leu Gly Met Phe Tyr Asp 
                85                  90                  95      


Thr Asp Asp Ala Ser Phe Lys Trp Phe Asp Asn Ser Asn Met Thr Phe 
            100                 105                 110         


Asp Lys Trp Thr Asp Gln Asp Asp Asp Glu Asp Leu Val Asp Thr Cys 
        115                 120                 125             


Ala Phe Leu His Ile Lys Thr Gly Glu Trp Lys Lys Gly Asn Cys Glu 
    130                 135                 140                 


Val Ser Ser Val Glu Gly Thr Leu Cys Lys Thr Ala Ile Pro Tyr Lys 
145                 150                 155                 160 


Arg Lys Tyr Leu Ser Asp Asn His Ile Leu Ile Ser Ala Leu Val Ile 
                165                 170                 175     


Ala Ser Thr Val Ile Leu Thr Val Leu Gly Ala Ile Ile Trp Phe Leu 
            180                 185                 190         


Tyr Lys Lys His Ser Asp Ser Arg Phe Thr Thr Val Phe Ser Thr Ala 
        195                 200                 205             


Pro Gln Ser Pro Tyr Asn Glu Asp Cys Val Leu Val Val Gly Glu Glu 
    210                 215                 220                 


Asn Glu Tyr Pro Val Gln Phe Asp 
225                 230         


<210>  653
<211>  6928
<212>  DNA
<213>  Homosapiens

<400>  653
ggcgggagcg cgtgcgcccg aggacccggc cggaaggctt gcgccagctc aggatgagga     60

caggctgggc gacccctcgc cgcccggcgg ggctcctcat gctgctcttc tggttcttcg    120

atctcgcgga gccctctggc cgcgcagcta atgacccctt caccatcgtc catggaaata    180

cgggcaagtg catcaagcca gtgtatggct ggatagtagc agacgactgt gatgaaactg    240

aggacaagtt atggaagtgg gtgtcccagc atcggctctt tcatttgcac tcccaaaagt    300

gccttggcct cgatattacc aaatcggtaa atgagctgag aatgttcagc tgtgactcca    360

gtgccatgct gtggtggaaa tgtgagcacc actctctgta cggagctgcc cggtaccggc    420

tggctctgaa ggatggacat ggcacagcaa tctcaaatgc atctgatgtc tggaagaaag    480

gaggctcaga ggaaagcctt tgtgaccagc cttatcatga gatctatacc agagatggga    540

actcttatgg gagaccttgt gaatttccat tcttaattga tgggacctgg catcatgatt    600

gcattcttga tgaagatcat agtgggccat ggtgtgccac caccttaaat tatgaatatg    660

accgaaagtg gggcatctgc ttaaagcctg aaaacggttg tgaagataat tgggaaaaga    720

acgagcagtt tggaagttgc taccaattta atactcagac ggctctttct tggaaagaag    780

cttatgtttc atgtcagaat caaggagctg atttactgag catcaacagt gctgctgaat    840

taacttacct taaagaaaaa gaaggcattg ctaagatttt ctggattggt ttaaatcagc    900

tatactctgc tagaggctgg gaatggtcag accacaaacc attaaacttt ctcaactggg    960

atccagacag gcccagtgca cctactatag gtggctccag ctgtgcaaga atggatgctg   1020

agtctggtct gtggcagagc ttttcctgtg aagctcaact gccctatgtc tgcaggaaac   1080

cattaaataa tacagtggag ttaacagatg tctggacata ctcagatacc cgctgtgatg   1140

caggctggct gccaaataat ggattttgct atctgctggt aaatgaaagt aattcctggg   1200

ataaggcaca tgcgaaatgc aaagccttca gtagtgacct aatcagcatt cattctctag   1260

cagatgtgga ggtggttgtc acaaaactcc ataatgagga tatcaaagaa gaagtgtgga   1320

taggccttaa gaacataaac ataccaactt tatttcagtg gtcagatggt actgaagtta   1380

ctctaacata ttgggatgag aatgagccaa atgttcccta caataagacg cccaactgtg   1440

tttcctactt aggagagcta ggtcagtgga aagtccaatc atgtgaggag aaactaaaat   1500

atgtatgcaa gagaaaggga gaaaaactga atgacgcaag ttctgataag atgtgtcctc   1560

cagatgaggg ctggaagaga catggagaaa cctgttacaa gatttatgag gatgaggtcc   1620

cttttggaac aaactgcaat ctgactatca ctagcagatt tgagcaagaa tacctaaatg   1680

atttgatgaa aaagtatgat aaatctctaa gaaaatactt ctggactggc ctgagagatg   1740

tagattcttg tggagagtat aactgggcaa ctgttggtgg aagaaggcgg gctgtaacct   1800

tttccaactg gaattttctt gagccagctt ccccgggcgg ctgcgtggct atgtctactg   1860

gaaagtctgt tggaaagtgg gaggtgaagg actgcagaag cttcaaagca ctttcaattt   1920

gcaagaaaat gagtggaccc cttgggcctg aagaagcatc ccctaagcct gatgacccct   1980

gtcctgaagg ctggcagagt ttccccgcaa gtctttcttg ttataaggta ttccatgcag   2040

aaagaattgt aagaaagagg aactgggaag aagctgaacg attctgccaa gcccttggag   2100

cacacctttc tagcttcagc catgtggatg aaataaagga atttcttcac tttttaacgg   2160

accagttcag tggccagcat tggctgtgga ttggtttgaa taaaaggagc ccagatttac   2220

aaggatcctg gcaatggagt gatcgtacac cagtgtctac tattatcatg ccaaatgagt   2280

ttcagcagga ttatgacatc agagactgtg ctgctgtcaa ggtatttcat aggccatggc   2340

gaagaggctg gcatttctat gatgatagag aatttattta tttgaggcct tttgcttgtg   2400

atacaaaact tgaatgggtg tgccaaattc caaaaggccg tactccaaaa acaccagact   2460

ggtacaatcc agaccgtgct ggaattcatg gacctccact tataattgaa ggaagtgaat   2520

attggtttgt tgctgatctt cacctaaact atgaagaagc cgtcctgtac tgtgccagca   2580

atcacagctt tcttgcgact ataacatctt ttgtgggact aaaagccatc aaaaacaaaa   2640

tagcaaatat atctggtgat ggacagaagt ggtggataag aattagcgag tggccaatag   2700

atgatcattt tacatactca cgatatccat ggcaccgctt tcctgtgaca tttggagagg   2760

aatgcttgta catgtctgcc aagacttggc ttatcgactt aggtaaacca acagactgta   2820

gtaccaagtt gcccttcatc tgtgaaaaat ataatgtttc ttcgttagag aaatacagcc   2880

cagattctgc agctaaagtg caatgttctg agcaatggat tccttttcag aataagtgtt   2940

ttctaaagat caaacccgtg tctctcacat tttctcaagc aagcgatacc tgtcactcct   3000

atggtggcac ccttccttca gtgttgagcc agattgaaca agactttatt acatccttgc   3060

ttccggatat ggaagctact ttatggattg gtttgcgctg gactgcctat gaaaagataa   3120

acaaatggac agataacaga gagctgacgt acagtaactt tcacccatta ttggttagtg   3180

ggaggctgag aataccagaa aatttttttg aggaagagtc tcgctaccac tgtgccctaa   3240

tactcaacct ccaaaaatca ccgtttactg ggacgtggaa ttttacatcc tgcagtgaac   3300

gccactttgt gtctctctgt cagaaatatt cagaagttaa aagcagacag acgttgcaga   3360

atgcttcaga aactgtaaag tatctaaata atctgtacaa aataatccca aagactctga   3420

cttggcacag tgctaaaagg gagtgtctga aaagtaacat gcagctggtg agcatcacgg   3480

acccttacca gcaggcattc ctcagtgtgc aggcgctcct tcacaactct tccttatgga   3540

tcggactctt cagtcaagat gatgaactca actttggttg gtcagatggg aaacgtcttc   3600

attttagtcg ctgggctgaa actaatgggc aactcgaaga ctgtgtagta ttagacactg   3660

atggattctg gaaaacagtt gattgcaatg acaatcaacc aggtgctatt tgctactatt   3720

caggaaatga gactgaaaaa gaggtcaaac cagttgacag tgttaaatgt ccatctcctg   3780

ttctaaatac tccgtggata ccatttcaga actgttgcta caatttcata ataacaaaga   3840

ataggcatat ggcaacaaca caggatgaag ttcatactaa atgccagaaa ctgaatccaa   3900

aatcacatat tctgagtatt cgagatgaaa aggagaataa ctttgttctt gagcaactgc   3960

tgtacttcaa ttatatggct tcatgggtca tgttaggaat aacttataga aataattctc   4020

ttatgtggtt tgataagacc ccactgtcat atacacattg gagagcagga agaccaacta   4080

taaaaaatga gaagtttttg gctggtttaa gtactgacgg cttctgggat attcaaacct   4140

ttaaagttat tgaagaagca gtttattttc accagcacag cattcttgct tgtaaaattg   4200

aaatggttga ctacaaagaa gaacataata ctacactgcc acagtttatg ccatatgaag   4260

atggtattta cagtgttatt caaaaaaagg taacatggta tgaagcatta aacatgtgtt   4320

ctcaaagtgg aggtcacttg gcaagcgttc acaaccaaaa tggccagctc tttctggaag   4380

atattgtaaa acgtgatgga tttccactat gggttgggct ctcaagtcat gatggaagtg   4440

aatcaagttt tgaatggtct gatggtagta catttgacta tatcccatgg aaaggccaaa   4500

catctcctgg aaattgtgtt ctcttggatc caaaaggaac ttggaaacat gaaaaatgca   4560

actctgttaa ggatggtgct atttgttata aacctacaaa atctaaaaag ctgtcccgtc   4620

ttacatattc atcaagatgt ccagcagcaa aagagaatgg gtcacggtgg atccagtaca   4680

agggtcactg ttacaagtct gatcaggcat tgcacagttt ttcagaggcc aaaaaattgt   4740

gttcaaaaca tgatcactct gcaactatcg tttccataaa agatgaagat gagaataaat   4800

ttgtgagcag actgatgagg gaaaataata acattaccat gagagtttgg cttggattat   4860

ctcaacattc tgttgaccag tcttggagtt ggttagatgg atcagaagtg acatttgtca   4920

aatgggaaaa taaaagtaag agtggtgttg gaagatgtag catgttgata gcttcaaatg   4980

aaacttggaa aaaagttgaa tgtgaacatg gttttggaag agttgtctgc aaagtgcctc   5040

tgggccctga ttacacagca atagctatca tagttgccac actaagtatc ttagttctca   5100

tgggcggact gatttggttc ctcttccaaa ggcaccgttt gcacctggcg ggtttctcat   5160

cagttcgata tgcacaagga gtgaatgaag atgagattat gcttccttct ttccatgact   5220

aaattcttct aaaagttttc taatttgcac taatgtggtt atggagaaat tagtcactta   5280

aaatgtccca gtgtcagtat ttactctgct ccaaagtaga actcttaaat actttttcag   5340

ttgtttagat cttaggcatg tgctggtatc cacagttaat tccctgctaa atgccatgtt   5400

tatcacccta attaatagaa tggaggggac tccaaagctg gaactgaagt ccaaattgtt   5460

tgtacagtaa tatgtttaat gttcattttc tctgtatgaa tgtgattggt aactaggata   5520

tgtatatttt aatagaattt ttaacaaaac ttcttagaaa attaaaatag gcatattact   5580

aggtgacatg tctacttttt aatttttaag agcatccggc caaatgcaaa attagtacct   5640

caaagtaaaa attgaactgt aaactctatc agcattgttt caaaatagtc atttttagca   5700

ctggggaaaa ataaacaata agacatgctt actttttaat ttttattttt ttgagactga   5760

gtctctctct gttgcccagg ctggagtaca atggcgtgat ctcggctcac tgcaaatctc   5820

cgcctcccag gttcaagcga ttctcctgcc tcagcctcct gagtagctgg gattacaggc   5880

aactgccacc atgcccggct aatttttgta tttttagtag agatggggtt tcaccatgtt   5940

ggccaggctg gtctcgaact cgtgaccgca gtgatcctcc cgcctcggcc tcccaaagtg   6000

ctgggattac aggcatgagc caccgcgcct ggcctctgct tactttttat atagcaaaat   6060

gattcccctt ggcaagatgt ttcttatatt attccaaagt tatttcatac cattattatg   6120

taaatatgaa gagttttttt ctgtttataa ttgtttataa aacaatgact tttaaagatt   6180

tagtgcttaa cattttccca agtgtgggaa cattattttt agattgagta ggtaccttgt   6240

agcagtgtgc tttgcatttt ctgatgtatt acatgactgt ttcttttgta aagagaatca   6300

actaggtatt taagactgat aattttacaa tttatatgct tcacatagca tgtcaacttt   6360

tgactaagaa ttttgtttta cttttttaac atgtgttaaa cagagaaagg gtccatgaag   6420

gaaagtgtat gagttgcatt tgtaaaaatg agactttttc agtggaactc taaaccttgt   6480

gatgactact aacaaatgta aaattatgag tgattaagaa aacattgctt tgtggttatc   6540

actttaagtt ttgacaccta gattatagtc ttagtaatag catccactgg aaaaggtgaa   6600

aatgttttat tcagcattta acttacattt gtactttaga gtatttttgt ataaaatcca   6660

tagatttatt ttacatttag agtatttaca ctatgataaa gttgtaaata attttctaag   6720

acagttttta tatagtctac agttgtcctg atttcttatt gaatttgtta gactagttct   6780

cttgtcttgt gatctgtgta caattttagt cactaagact ttcctccaag aactaagcca   6840

acttgatgtg aaaagcacgg ctgtatataa tggtgatgtc ataataaagt tgttttatct   6900

tttaagtaaa aaaaaaaaaa aaaaaaaa                                      6928


<210>  654
<211>  1722
<212>  PRT
<213>  Homosapiens

<400>  654

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Asn Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  His Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Gln Ser  Trp Ser Trp Leu Asp  Gly Ser Glu Val Thr  Phe Val Lys 
    1610                 1615                 1620             


Trp Glu  Asn Lys Ser Lys Ser  Gly Val Gly Arg Cys  Ser Met Leu 
    1625                 1630                 1635             


Ile Ala  Ser Asn Glu Thr Trp  Lys Lys Val Glu Cys  Glu His Gly 
    1640                 1645                 1650             


Phe Gly  Arg Val Val Cys Lys  Val Pro Leu Gly Pro  Asp Tyr Thr 
    1655                 1660                 1665             


Ala Ile  Ala Ile Ile Val Ala  Thr Leu Ser Ile Leu  Val Leu Met 
    1670                 1675                 1680             


Gly Gly  Leu Ile Trp Phe Leu  Phe Gln Arg His Arg  Leu His Leu 
    1685                 1690                 1695             


Ala Gly  Phe Ser Ser Val Arg  Tyr Ala Gln Gly Val  Asn Glu Asp 
    1700                 1705                 1710             


Glu Ile  Met Leu Pro Ser Phe  His Asp 
    1715                 1720         


<210>  655
<211>  5160
<212>  DNA
<213>  Homosapiens

<400>  655
cccgagtgtc ggttcactgt ggagacagcg gtggcggagt gggtctccag ggctctgggc     60

tggcaaggcc cccggagggg gtggggcgcg gaggaggcta cggatccgct tccgcgcggc    120

ggggccgggt gcttgggacg cggctctggg ctcccgggat aaggggctcc cgggacaagg    180

ggctcccgga gagcccagtg gttagcgatg ctgctgtcgc cgtcgctgct gctgctgctg    240

ctgctggggg cgccgcgggg ctgcgccgag ggtgtggcgg cggcgcttac ccccgagcgg    300

ctcctggagt ggcaggataa aggaatattt gttatccaaa gtgagagtct caagaaatgc    360

attcaagcag gtaaatcggt tctgaccctg gagaactgca agcaagcaaa caagcacatg    420

ctgtggaaat gggtttcaaa ccatggcctc tttaacatag gaggcagtgg ttgcctgggc    480

ctgaatttct ccgccccaga gcagccatta agcttatatg aatgtgactc caccctcgtt    540

tccttacggt ggcgctgtaa caggaagatg atcacaggcc cgctgcagta ctctgtccag    600

gtggcgcatg acaacacagt ggtggcctca cggaagtata ttcataagtg gatttcttat    660

gggtcaggtg gtggagacat ttgtgaatat ctacacaaag atttgcatac aatcaaaggg    720

aacacccacg ggatgccgtg tatgtttccc ttccagtata accatcagtg gcatcatgaa    780

tgtacccgtg aaggtcggga agatgactta ctgtggtgtg ccacgacaag ccgttatgaa    840

agagatgaaa agtggggatt ttgccctgat cccacctctg cagaagtagg ttgtgatact    900

atttgggaga aggacctcaa ttcacacatt tgctaccagt tcaacctgct ttcatctctc    960

tcttggagtg aggcacattc ttcatgccag atgcaaggag gtacgctgtt aagtattaca   1020

gatgaaactg aagaaaattt cataagggag cacatgagca gtaaaacagt ggaggtgtgg   1080

atgggcctca atcagctgga tgaacacgct ggctggcagt ggtctgatgg aacgccgctc   1140

aactatctga attggagccc agaggtaaat tttgagccat ttgttgaaga tcactgtgga   1200

acatttagtt catttatgcc aagtgcctgg aggagtcggg attgtgagtc caccttgcca   1260

tatatatgta aaaaatatct aaaccacatt gatcatgaaa tagttgaaaa agatgcgtgg   1320

aaatattatg ctacccactg tgagcctggc tggaatccct acaatcgtaa ttgctacaaa   1380

cttcagaaag aagaaaagac ctggcatgag gctctgcgtt cttgtcaggc tgataacagt   1440

gcattaatag acataacctc attagcagag gtggagtttc ttgtaaccct ccttggagat   1500

gaaaatgcat cagaaacatg gattggtttg agcagcaata aaattccagt ttcctttgaa   1560

tggtctaatg actcttcagt catctttact aattggcaca cacttgagcc ccacattttt   1620

ccaaatagaa gccagctgtg tgtctcagca gagcagtctg agggacactg gaaagtcaaa   1680

aattgtgaag aaagactttt ttacatttgt aaaaaagcag gccatgtcct ctctgatgct   1740

gaatcaggat gtcaagaggg atgggagaga catggtggat tctgttacaa aattgacaca   1800

gtccttcgaa gctttgacca agcttccagc ggttattact gtcctcctgc acttgtaacc   1860

attacaaaca ggtttgaaca ggcttttatt accagtttga tcagtagtgt ggtaaaaatg   1920

aaggacagtt atttttggat agctcttcag gaccaaaatg atacgggaga atacacttgg   1980

aagccagtag ggcagaaacc cgagccggtg cagtacacac actggaacac acaccagccg   2040

cgctacagtg gtggctgtgt tgccatgcga ggaaggcatc cacttggtcg ctgggaagtg   2100

aagcactgtc ggcactttaa ggcaatgtcc ttgtgcaagc agccagttga aaatcaggaa   2160

aaagcagagt atgaagagag atggcccttt cacccctgct atttggactg ggagtcagag   2220

cctggtctgg ccagttgctt caaggtattt catagtgaaa aagttctgat gaaaagaaca   2280

tggagagaag ctgaagcatt ttgcgaagaa tttggagctc atcttgcaag ctttgcccat   2340

attgaggaag agaattttgt gaatgagctc ttacattcaa aatttaattg gacagaagaa   2400

aggcagttct ggattggatt taataaaaga aacccactga atgccggctc atgggagtgg   2460

tctgatagaa ctcctgttgt ctcttcgttt ttagacaaca cttattttgg agaagatgca   2520

agaaactgtg ctgtttataa ggcaaacaaa acattgctgc ccttacactg tggttccaaa   2580

cgtgaatgga tatgcaaaat cccaagagat gtgaaaccca agattccgtt ctggtaccag   2640

tacgatgtac cctggctctt ttatcaggat gcagaatacc tttttcatac ctttgcctca   2700

gaatggttga actttgagtt tgtctgtagc tggctgcaca gtgatcttct cacaattcat   2760

tctgcacatg agcaagaatt catccacagc aaaataaaag cgctatcaaa gtatggtgca   2820

agttggtgga ttggacttca agaagaaaga gccaatgatg aatttcgctg gagagatgga   2880

acaccagtga tataccagaa ctgggacaca ggaagagaaa gaactgtgaa taatcagagc   2940

cagagatgtg gctttatttc ttctataaca ggactctggg gtagtgaaga gtgttcagtt   3000

tctatgccta gtatctgtaa gcgaaaaaag gtttggctca tagagaaaaa gaaagataca   3060

ccaaaacaac atggaacgtg tcccaaagga tggctatatt ttaactataa gtgccttctg   3120

ctgaatatcc ccaaagaccc aagcagttgg aagaactgga cgcatgctca acatttctgt   3180

gctgaagaag gggggaccct ggtcgccatt gaaagtgagg tggagcaagc tttcattact   3240

atgaatcttt ttggccagac caccagtgtg tggataggtt tacaaaatga tgattatgaa   3300

acatggctaa atggaaagcc tgtggtatat tctaactggt ctccatttga tataataaat   3360

attccaagtc acaataccac tgaagttcag aaacacattc ctctctgtgc cttactctca   3420

agtaatccta attttcattt cactggaaaa tggtattttg aagactgtgg aaaggaaggc   3480

tatgggtttg tttgtgaaaa aatgcaagat acttctggac acggtgtaaa tacatctgat   3540

atgtatccaa tgcccaatac cttagaatat ggaaacagaa cttacaaaat aattaatgca   3600

aatatgactt ggtatgcagc aataaaaacc tgcctgatgc acaaagcaca actggtcagc   3660

atcacagacc agtatcacca gtccttcctc actgttgtcc tcaaccggct aggatatgcc   3720

cactggattg gactgttcac cacagataat ggtcttaatt ttgactggtc tgatggcacc   3780

aaatcttctt tcactttttg gaaagatgag gagtcctccc tccttggtga ctgcgttttt   3840

gccgacagca acggacgctg gcatagcaca gcctgcgagt catttctgca aggtgccatt   3900

tgtcatgtgc cacctgaaac aagacaatct gaacacccag agttgtgctc agaaacatct   3960

attccctgga taaaatttaa aagtaattgc tacagttttt ctacagtcct agacagtatg   4020

agttttgagg ctgctcatga attttgcaaa aaggaaggtt ctaatctttt aacaatcaag   4080

gatgaggctg aaaatgcatt tctcctagaa gagctgtttg cttttggttc ttctgtccag   4140

atggtttggt tgaatgctca atttgatggt aacagtaagt gatttgggta gaggagagga   4200

cataaataaa tacatggttg ttaaagctga tgataatggc atctgtgagc cagaaaactc   4260

tccttggata cgttttctga gaaaaaatag catgaagcct aaagccattt cttccaaaaa   4320

caacattgca acccttttct ttaccctttt gtcttttaaa ataatcccag aacaccaaaa   4380

ataaaaacaa acaataacat gtttatcttt acccttagca ggaagatgct tggctggaac   4440

tttgtgttca cagacttagt cattgcatac caaaaccata tttactggaa aatatcccag   4500

gtttctaaat gttataaaag cacaatagag ttatggaaat gtttccatga tgaactgtgc   4560

tgttaggatt cttatttgct actcataaaa accagagttt gtaataaaat ggaagcatgg   4620

tattcttttc tttatgtaat tgatggttat tgaaaggtac ttgtgaagaa aattatttta   4680

attggtatgg agagcttgtt acagtggtgt accaaggttg ggggtgagcc taccctttcg   4740

aggaggagta ttttaatcac caacattgtt tagaatttca agcagatggt gataataaaa   4800

agcagaccaa cttttagtta gctgtattgt tagttttaaa ttattttcag acaatacact   4860

attgcccaca catgggatgg actctcctac cgcccctacc cccttggtac atggctggct   4920

tggtattaaa gaaattcact gtaaaatctt tttagaaagt gagccatttt gtaatgatga   4980

agatgttagg acttcaaagg atttttcttt actcgattag ttttgtttat caaatgattt   5040

ctttaaatcg attatatata tatatggaat atttcaaaat tcaaactgtc acattaagaa   5100

acatgataac ctaaatgacc taaataagaa cactgtacct aaaataaaga ggcaacttta   5160


<210>  656
<211>  1324
<212>  PRT
<213>  Homosapiens

<400>  656

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Ser 
    1310                 1315                 1320             


Lys 
    


<210>  657
<211>  4876
<212>  DNA
<213>  Homosapiens

<400>  657
cccgagtgtc ggttcactgt ggagacagcg gtggcggagt gggtctccag ggctctgggc     60

tggcaaggcc cccggagggg gtggggcgcg gaggaggcta cggatccgct tccgcgcggc    120

ggggccgggt gcttgggacg cggctctggg ctcccgggat aaggggctcc cgggacaagg    180

ggctcccgga gagcccagtg gttagcgatg ctgctgtcgc cgtcgctgct gctgctgctg    240

ctgctggggg cgccgcgggg ctgcgccgag ggtgtggcgg cggcgcttac ccccgagcgg    300

ctcctggagt ggcaggataa aggaatattt gttatccaaa gtgagagtct caagaaatgc    360

attcaagcag gtaaatcggt tctgaccctg gagaactgca agcaagcaaa caagcacatg    420

ctgtggaaat gggtttcaaa ccatggcctc tttaacatag gaggcagtgg ttgcctgggc    480

ctgaatttct ccgccccaga gcagccatta agcttatatg aatgtgactc caccctcgtt    540

tccttacggt ggcgctgtaa caggaagatg atcacaggcc cgctgcagta ctctgtccag    600

gtggcgcatg acaacacagt ggtggcctca cggaagtata ttcataagtg gatttcttat    660

gggtcaggtg gtggagacat ttgtgaatat ctacacaaag atttgcatac aatcaaaggg    720

aacacccacg ggatgccgtg tatgtttccc ttccagtata accatcagtg gcatcatgaa    780

tgtacccgtg aaggtcggga agatgactta ctgtggtgtg ccacgacaag ccgttatgaa    840

agagatgaaa agtggggatt ttgccctgat cccacctctg cagaagtagg ttgtgatact    900

atttgggaga aggacctcaa ttcacacatt tgctaccagt tcaacctgct ttcatctctc    960

tcttggagtg aggcacattc ttcatgccag atgcaaggag gtacgctgtt aagtattaca   1020

gatgaaactg aagaaaattt cataagggag cacatgagca gtaaaacagt ggaggtgtgg   1080

atgggcctca atcagctgga tgaacacgct ggctggcagt ggtctgatgg aacgccgctc   1140

aactatctga attggagccc agaggtaaat tttgagccat ttgttgaaga tcactgtgga   1200

acatttagtt catttatgcc aagtgcctgg aggagtcggg attgtgagtc caccttgcca   1260

tatatatgta aaaaatatct aaaccacatt gatcatgaaa tagttgaaaa agatgcgtgg   1320

aaatattatg ctacccactg tgagcctggc tggaatccct acaatcgtaa ttgctacaaa   1380

cttcagaaag aagaaaagac ctggcatgag gctctgcgtt cttgtcaggc tgataacagt   1440

gcattaatag acataacctc attagcagag gtggagtttc ttgtaaccct ccttggagat   1500

gaaaatgcat cagaaacatg gattggtttg agcagcaata aaattccagt ttcctttgaa   1560

tggtctaatg actcttcagt catctttact aattggcaca cacttgagcc ccacattttt   1620

ccaaatagaa gccagctgtg tgtctcagca gagcagtctg agggacactg gaaagtcaaa   1680

aattgtgaag aaagactttt ttacatttgt aaaaaagcag gccatgtcct ctctgatgct   1740

gaatcaggat gtcaagaggg atgggagaga catggtggat tctgttacaa aattgacaca   1800

gtccttcgaa gctttgacca agcttccagc ggttattact gtcctcctgc acttgtaacc   1860

attacaaaca ggtttgaaca ggcttttatt accagtttga tcagtagtgt ggtaaaaatg   1920

aaggacagtt atttttggat agctcttcag gaccaaaatg atacgggaga atacacttgg   1980

aagccagtag ggcagaaacc cgagccggtg cagtacacac actggaacac acaccagccg   2040

cgctacagtg gtggctgtgt tgccatgcga ggaaggcatc cacttggtcg ctgggaagtg   2100

aagcactgtc ggcactttaa ggcaatgtcc ttgtgcaagc agccagttga aaatcaggaa   2160

aaagcagagt atgaagagag atggcccttt cacccctgct atttggactg ggagtcagag   2220

cctggtctgg ccagttgctt caaggtattt catagtgaaa aagttctgat gaaaagaaca   2280

tggagagaag ctgaagcatt ttgcgaagaa tttggagctc atcttgcaag ctttgcccat   2340

attgaggaag agaattttgt gaatgagctc ttacattcaa aatttaattg gacagaagaa   2400

aggcagttct ggattggatt taataaaaga aacccactga atgccggctc atgggagtgg   2460

tctgatagaa ctcctgttgt ctcttcgttt ttagacaaca cttattttgg agaagatgca   2520

agaaactgtg ctgtttataa ggcaaacaaa acattgctgc ccttacactg tggttccaaa   2580

cgtgaatgga tatgcaaaat cccaagagat gtgaaaccca agattccgtt ctggtaccag   2640

tacgatgtac cctggctctt ttatcaggat gcagaatacc tttttcatac ctttgcctca   2700

gaatggttga actttgagtt tgtctgtagc tggctgcaca gtgatcttct cacaattcat   2760

tctgcacatg agcaagaatt catccacagc aaaataaaag cgctatcaaa gtatggtgca   2820

agttggtgga ttggacttca agaagaaaga gccaatgatg aatttcgctg gagagatgga   2880

acaccagtga tataccagaa ctgggacaca ggaagagaaa gaactgtgaa taatcagagc   2940

cagagatgtg gctttatttc ttctataaca ggactctggg gtagtgaaga gtgttcagtt   3000

tctatgccta gtatctgtaa gcgaaaaaag gtttggctca tagagaaaaa gaaagataca   3060

ccaaaacaac atggaacgtg tcccaaagga tggctatatt ttaactataa gtgccttctg   3120

ctgaatatcc ccaaagaccc aagcagttgg aagaactgga cgcatgctca acatttctgt   3180

gctgaagaag gggggaccct ggtcgccatt gaaagtgagg tggagcaagc tttcattact   3240

atgaatcttt ttggccagac caccagtgtg tggataggtt tacaaaatga tgattatgaa   3300

acatggctaa atggaaagcc tgtggtatat tctaactggt ctccatttga tataataaat   3360

attccaagtc acaataccac tgaagttcag aaacacattc ctctctgtgc cttactctca   3420

agtaatccta attttcattt cactggaaaa tggtattttg aagactgtgg aaaggaaggc   3480

tatgggtttg tttgtgaaaa aatgcaagat acttctggac acggtgtaaa tacatctgat   3540

atgtatccaa tgcccaatac cttagaatat ggaaacagaa cttacaaaat aattaatgca   3600

aatatgactt ggtatgcagc aataaaaacc tgcctgatgc acaaagcaca actggtcagc   3660

atcacagacc agtatcacca gtccttcctc actgttgtcc tcaaccggct aggatatgcc   3720

cactggattg gactgttcac cacagataat ggtcttaatt ttgactggtc tgatggcacc   3780

aaatcttctt tcactttttg gaaagatgag gagtcctccc tccttggtga ctgcgttttt   3840

gccgacagca acggacgctg gcatagcaca gcctgcgagt catttctgca aggtgccatt   3900

tgtcatgtgc cacctgaaac aagacaatct gaacacccag agttgtgctc agaaacatct   3960

attccctgga taaaatttaa aagtaattgc tacagttttt ctacagtcct agacagtatg   4020

agttttgagg ctgctcatga attttgcaaa aaggaaggtt ctaatctttt aacaatcaag   4080

gatgaggctg aaaatgcatt tctcctagaa gagctgtttg cttttggttc ttctgtccag   4140

atggtttggt tgaatgctca atttgatggt aacaatgaaa ccataaagtg gtttgatgga   4200

actcccacag accagtcaaa ctggggcatt cggaagccag acacagacta cttcaagccc   4260

catcattgtg ttgccttgag gatccctgaa ggattatggc agctatcccc gtgtcaagaa   4320

aaaaaaggct ttatatgtaa aatggaggca gatattcaca ctgcagaggc gctgccagaa   4380

aaaggaccaa gtcacagcat cattcctctt gcggttgtac tgacactgat agtcattgtg   4440

gccatttgca cactttcctt ctgcatatac aagcataacg gtggcttctt caggagactt   4500

gcagggtttc ggaatcctta ctatcctgca accaacttta gtacagtata tttagaagaa   4560

aatattctca tttctgatct tgagaagagt gaccaataat aatgaggtca gagaatgcca   4620

cagacaccag ggtaagtaaa gaagactaaa caggagtctc atctgtcttt ccctttacag   4680

cacagatgcc attagaatgt gaattgggtc actattttaa ttattcttga agtgattact   4740

ggttttgaat cttaaccaaa tcagatgggt tttgatttat tcatttccct aaactgtgat   4800

ccattcttaa aaggggtaaa ttatgcattg gttatttttc agaaagacaa gaactattaa   4860

aagaaactcc ctattg                                                   4876


<210>  658
<211>  1463
<212>  PRT
<213>  Homosapiens

<400>  658

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Asp  Thr Asp Tyr Phe Lys  Pro His His 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Leu Trp Gln  Leu Ser Pro 
    1355                 1360                 1365             


Cys Gln  Glu Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Ala Glu Ala Leu Pro  Glu Lys Gly Pro Ser  His Ser Ile 
    1385                 1390                 1395             


Ile Pro  Leu Ala Val Val Leu  Thr Leu Ile Val Ile  Val Ala Ile 
    1400                 1405                 1410             


Cys Thr  Leu Ser Phe Cys Ile  Tyr Lys His Asn Gly  Gly Phe Phe 
    1415                 1420                 1425             


Arg Arg  Leu Ala Gly Phe Arg  Asn Pro Tyr Tyr Pro  Ala Thr Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val Tyr Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Ser Asp Gln 
    1460             


<210>  659
<211>  1635
<212>  DNA
<213>  Homosapiens

<400>  659
caacatgagg gacccactga cagattgtcc gtataataaa gtatacaaga acctaaagga     60

gttttctcaa aatggagaga atttctgcaa acaggtcaca tctgttcttc agcaaagggc    120

aaacctggaa attagctatg ccaaaggact tcagaaactg gcaagcaagc tgagcaaagc    180

attacagaac acgagaaaaa gttgtgttag cagtgcctgg gcctgggcct cagagggaat    240

gaaatccaca gcggacctgc atcaaaaact tggcaaagca attgaattgg aagcaataaa    300

accgacttat caagtcctaa atgtacaaga gaagaagaga aaatcacttg acaatgaagt    360

tgaaaagaca gcaaatcttg tcattagcaa ctggaatcag caaattaagg ccaagaagaa    420

attaatggtt agtaccaaga aacatgaagc acttttccag cttgtagaaa gctccaagca    480

atctatgact gagaaggaga agcggaagct cctcaataaa ctgacaaaat caactgaaaa    540

gttggaaaag gaagatgaaa attactacca aaaaaacatg gcgggttatt ctaccagact    600

gaaatgggaa aacacactag agaactgcta ccagagcatt ctggagctgg agaaggaaag    660

aattcaactt ttatgcaata acttaaacca gtacagccaa catatttctc tttttggcca    720

aaccctgacc acatgccaca cgcagattca ctgtgccatc agcaagattg acattgaaaa    780

agatatccag gctgtaatgg aagaaactgc aattttatct acagaaaaca aatctgagtt    840

cctgttaacg gattactttg aagaagatcc taacagtgca atggataaag agagacgaaa    900

gtctttacta aaaccaaaat tattgagact gcagagagac attgaaaaag cctcaaaaga    960

caaggaaggc ctggaacgaa tgcttaaaac gtactccagc acctcctcct tctctgatgc   1020

aaagagccag aaagacacag cagcgttaat ggatgagaac aatttgaaac tagacctttt   1080

ggaagcgaac tcctacaaac tgtcatcaat gttagcagaa cttgagcaaa gacctcaacc   1140

cagccatcct tgtagtaatt ccatcttcag gtggagggaa aaggagcata ctcatagcta   1200

tgtgaaaata tctcggcctt ttttaatgaa gagattagag aatattgtga gcaaggcatc   1260

ttctggtggg cagagcaatc caggttcttc aactccagcc cctggtgcag cccagctcag   1320

cagcagactt tgcaaggcct tgtattcttt tcaagccagg caagatgatg agttgaattt   1380

ggaaaagggt gacattgtga ttatacacga gaaaaaagaa gaaggatggt ggtttggatc   1440

tttgaatggg aaaaaaggcc attttcctgc cgcttatgtg gaggagttac cttcaaatgc   1500

tggcaacaca gctacaaagg cataaaacaa gactctgaac atactacctt cacactcggt   1560

aatcaacaat acagtgtggt tcaaataaga ataaagtgct cttacccaaa aaaaaaaaaa   1620

aaaaaaaaaa aaaaa                                                    1635


<210>  660
<211>  506
<212>  PRT
<213>  Homosapiens

<400>  660

Met Arg Asp Pro Leu Thr Asp Cys Pro Tyr Asn Lys Val Tyr Lys Asn 
1               5                   10                  15      


Leu Lys Glu Phe Ser Gln Asn Gly Glu Asn Phe Cys Lys Gln Val Thr 
            20                  25                  30          


Ser Val Leu Gln Gln Arg Ala Asn Leu Glu Ile Ser Tyr Ala Lys Gly 
        35                  40                  45              


Leu Gln Lys Leu Ala Ser Lys Leu Ser Lys Ala Leu Gln Asn Thr Arg 
    50                  55                  60                  


Lys Ser Cys Val Ser Ser Ala Trp Ala Trp Ala Ser Glu Gly Met Lys 
65                  70                  75                  80  


Ser Thr Ala Asp Leu His Gln Lys Leu Gly Lys Ala Ile Glu Leu Glu 
                85                  90                  95      


Ala Ile Lys Pro Thr Tyr Gln Val Leu Asn Val Gln Glu Lys Lys Arg 
            100                 105                 110         


Lys Ser Leu Asp Asn Glu Val Glu Lys Thr Ala Asn Leu Val Ile Ser 
        115                 120                 125             


Asn Trp Asn Gln Gln Ile Lys Ala Lys Lys Lys Leu Met Val Ser Thr 
    130                 135                 140                 


Lys Lys His Glu Ala Leu Phe Gln Leu Val Glu Ser Ser Lys Gln Ser 
145                 150                 155                 160 


Met Thr Glu Lys Glu Lys Arg Lys Leu Leu Asn Lys Leu Thr Lys Ser 
                165                 170                 175     


Thr Glu Lys Leu Glu Lys Glu Asp Glu Asn Tyr Tyr Gln Lys Asn Met 
            180                 185                 190         


Ala Gly Tyr Ser Thr Arg Leu Lys Trp Glu Asn Thr Leu Glu Asn Cys 
        195                 200                 205             


Tyr Gln Ser Ile Leu Glu Leu Glu Lys Glu Arg Ile Gln Leu Leu Cys 
    210                 215                 220                 


Asn Asn Leu Asn Gln Tyr Ser Gln His Ile Ser Leu Phe Gly Gln Thr 
225                 230                 235                 240 


Leu Thr Thr Cys His Thr Gln Ile His Cys Ala Ile Ser Lys Ile Asp 
                245                 250                 255     


Ile Glu Lys Asp Ile Gln Ala Val Met Glu Glu Thr Ala Ile Leu Ser 
            260                 265                 270         


Thr Glu Asn Lys Ser Glu Phe Leu Leu Thr Asp Tyr Phe Glu Glu Asp 
        275                 280                 285             


Pro Asn Ser Ala Met Asp Lys Glu Arg Arg Lys Ser Leu Leu Lys Pro 
    290                 295                 300                 


Lys Leu Leu Arg Leu Gln Arg Asp Ile Glu Lys Ala Ser Lys Asp Lys 
305                 310                 315                 320 


Glu Gly Leu Glu Arg Met Leu Lys Thr Tyr Ser Ser Thr Ser Ser Phe 
                325                 330                 335     


Ser Asp Ala Lys Ser Gln Lys Asp Thr Ala Ala Leu Met Asp Glu Asn 
            340                 345                 350         


Asn Leu Lys Leu Asp Leu Leu Glu Ala Asn Ser Tyr Lys Leu Ser Ser 
        355                 360                 365             


Met Leu Ala Glu Leu Glu Gln Arg Pro Gln Pro Ser His Pro Cys Ser 
    370                 375                 380                 


Asn Ser Ile Phe Arg Trp Arg Glu Lys Glu His Thr His Ser Tyr Val 
385                 390                 395                 400 


Lys Ile Ser Arg Pro Phe Leu Met Lys Arg Leu Glu Asn Ile Val Ser 
                405                 410                 415     


Lys Ala Ser Ser Gly Gly Gln Ser Asn Pro Gly Ser Ser Thr Pro Ala 
            420                 425                 430         


Pro Gly Ala Ala Gln Leu Ser Ser Arg Leu Cys Lys Ala Leu Tyr Ser 
        435                 440                 445             


Phe Gln Ala Arg Gln Asp Asp Glu Leu Asn Leu Glu Lys Gly Asp Ile 
    450                 455                 460                 


Val Ile Ile His Glu Lys Lys Glu Glu Gly Trp Trp Phe Gly Ser Leu 
465                 470                 475                 480 


Asn Gly Lys Lys Gly His Phe Pro Ala Ala Tyr Val Glu Glu Leu Pro 
                485                 490                 495     


Ser Asn Ala Gly Asn Thr Ala Thr Lys Ala 
            500                 505     


<210>  661
<211>  1588
<212>  DNA
<213>  Homosapiens

<400>  661
ccagaatgct ggagcgtagg tgaaaggaca aaagccagac acatttcaac atgagggacc     60

cactgacaga ttgtccgggc aaacctggaa attagctatg ccaaaggact tcagaaactg    120

gcaagcaagc tgagcaaagc attacagaac acgagaaaaa gttgtgttag cagtgcctgg    180

gcctgggcct cagagggaat gaaatccaca gcggacctgc atcaaaaact tggcaaagca    240

attgaattgg aagcaataaa accgacttat caagtcctaa atgtacaaga gaagaagaga    300

aaatcacttg acaatgaagt tgaaaagaca gcaaatcttg tcattagcaa ctggaatcag    360

caaattaagg ccaagaagaa attaatggtt agtaccaaga aacatgaagc acttttccag    420

cttgtagaaa gctccaagca atctatgact gagaaggaga agcggaagct cctcaataaa    480

ctgacaaaat caactgaaaa gttggaaaag gaagatgaaa attactacca aaaaaacatg    540

gcgggttatt ctaccagact gaaatgggaa aacacactag agaactgcta ccagagcatt    600

ctggagctgg agaaggaaag aattcaactt ttatgcaata acttaaacca gtacagccaa    660

catatttctc tttttggcca aaccctgacc acatgccaca cgcagattca ctgtgccatc    720

agcaagattg acattgaaaa agatatccag gctgtaatgg aagaaactgc aattttatct    780

acagaaaaca aatctgagtt cctgttaacg gattactttg aagaagatcc taacagtgca    840

atggataaag agagacgaaa gtctttacta aaaccaaaat tattgagact gcagagagac    900

attgaaaaag cctcaaaaga caaggaaggc ctggaacgaa tgcttaaaac gtactccagc    960

acctcctcct tctctgatgc aaagagccag aaagacacag cagcgttaat ggatgagaac   1020

aatttgaaac tagacctttt ggaagcgaac tcctacaaac tgtcatcaat gttagcagaa   1080

cttgagcaaa gacctcaacc cagccatcct tgtagtaatt ccatcttcag gtggagggaa   1140

aaggagcata ctcatagcta tgtgaaaata tctcggcctt ttttaatgaa gagattagag   1200

aatattgtga gcaaggcatc ttctggtggg cagagcaatc caggttcttc aactccagcc   1260

cctggtgcag cccagctcag cagcagactt tgcaaggcct tgtattcttt tcaagccagg   1320

caagatgatg agttgaattt ggaaaagggt gacattgtga ttatacacga gaaaaaagaa   1380

gaaggatggt ggtttggatc tttgaatggg aaaaaaggcc attttcctgc cgcttatgtg   1440

gaggagttac cttcaaatgc tggcaacaca gctacaaagg cataaaacaa gactctgaac   1500

atactacctt cacactcggt aatcaacaat acagtgtggt tcaaataaga ataaagtgct   1560

cttaccttta aaaaaaaaaa aaaaaaaa                                      1588


<210>  662
<211>  428
<212>  PRT
<213>  Homosapiens

<400>  662

Met Lys Ser Thr Ala Asp Leu His Gln Lys Leu Gly Lys Ala Ile Glu 
1               5                   10                  15      


Leu Glu Ala Ile Lys Pro Thr Tyr Gln Val Leu Asn Val Gln Glu Lys 
            20                  25                  30          


Lys Arg Lys Ser Leu Asp Asn Glu Val Glu Lys Thr Ala Asn Leu Val 
        35                  40                  45              


Ile Ser Asn Trp Asn Gln Gln Ile Lys Ala Lys Lys Lys Leu Met Val 
    50                  55                  60                  


Ser Thr Lys Lys His Glu Ala Leu Phe Gln Leu Val Glu Ser Ser Lys 
65                  70                  75                  80  


Gln Ser Met Thr Glu Lys Glu Lys Arg Lys Leu Leu Asn Lys Leu Thr 
                85                  90                  95      


Lys Ser Thr Glu Lys Leu Glu Lys Glu Asp Glu Asn Tyr Tyr Gln Lys 
            100                 105                 110         


Asn Met Ala Gly Tyr Ser Thr Arg Leu Lys Trp Glu Asn Thr Leu Glu 
        115                 120                 125             


Asn Cys Tyr Gln Ser Ile Leu Glu Leu Glu Lys Glu Arg Ile Gln Leu 
    130                 135                 140                 


Leu Cys Asn Asn Leu Asn Gln Tyr Ser Gln His Ile Ser Leu Phe Gly 
145                 150                 155                 160 


Gln Thr Leu Thr Thr Cys His Thr Gln Ile His Cys Ala Ile Ser Lys 
                165                 170                 175     


Ile Asp Ile Glu Lys Asp Ile Gln Ala Val Met Glu Glu Thr Ala Ile 
            180                 185                 190         


Leu Ser Thr Glu Asn Lys Ser Glu Phe Leu Leu Thr Asp Tyr Phe Glu 
        195                 200                 205             


Glu Asp Pro Asn Ser Ala Met Asp Lys Glu Arg Arg Lys Ser Leu Leu 
    210                 215                 220                 


Lys Pro Lys Leu Leu Arg Leu Gln Arg Asp Ile Glu Lys Ala Ser Lys 
225                 230                 235                 240 


Asp Lys Glu Gly Leu Glu Arg Met Leu Lys Thr Tyr Ser Ser Thr Ser 
                245                 250                 255     


Ser Phe Ser Asp Ala Lys Ser Gln Lys Asp Thr Ala Ala Leu Met Asp 
            260                 265                 270         


Glu Asn Asn Leu Lys Leu Asp Leu Leu Glu Ala Asn Ser Tyr Lys Leu 
        275                 280                 285             


Ser Ser Met Leu Ala Glu Leu Glu Gln Arg Pro Gln Pro Ser His Pro 
    290                 295                 300                 


Cys Ser Asn Ser Ile Phe Arg Trp Arg Glu Lys Glu His Thr His Ser 
305                 310                 315                 320 


Tyr Val Lys Ile Ser Arg Pro Phe Leu Met Lys Arg Leu Glu Asn Ile 
                325                 330                 335     


Val Ser Lys Ala Ser Ser Gly Gly Gln Ser Asn Pro Gly Ser Ser Thr 
            340                 345                 350         


Pro Ala Pro Gly Ala Ala Gln Leu Ser Ser Arg Leu Cys Lys Ala Leu 
        355                 360                 365             


Tyr Ser Phe Gln Ala Arg Gln Asp Asp Glu Leu Asn Leu Glu Lys Gly 
    370                 375                 380                 


Asp Ile Val Ile Ile His Glu Lys Lys Glu Glu Gly Trp Trp Phe Gly 
385                 390                 395                 400 


Ser Leu Asn Gly Lys Lys Gly His Phe Pro Ala Ala Tyr Val Glu Glu 
                405                 410                 415     


Leu Pro Ser Asn Ala Gly Asn Thr Ala Thr Lys Ala 
            420                 425             


<210>  663
<211>  1375
<212>  DNA
<213>  Homosapiens

<400>  663
gtttgaaatc ggaaagttgg cggggctgcg ggagctgagc ctagagtccg gctgttggct     60

agagtgggcg cggatctggt gtggggaagg cggcgggact caggcctgcc tgcgaagcat    120

tgtcctacat aatggtagag gacgaactgg cacttttcga taaaagcata aatgaatttt    180

ggaataaatt caaaagtacg gacacctcct gtcagatggc gggactaaga gatacctaca    240

aggattccat caaagcattt gcagaaaagc tgtctgtgaa attaaaggaa gaagaacgaa    300

tggttgagat gtttctggaa tatcaaaatc agatcagcag gcaaaataag ctcattcaag    360

aaaaaaagga taacttgtta aaattgattg ctgaagtaaa aggcaaaaag caggaattgg    420

aagtactgac tgcaaatatc caggatctta aggaagaata ttctaggaag aaggaaacta    480

tttctactgc taataaagcg aatgcagaga ggttgaaaag gctgcagaaa tctgcagact    540

tgtataaaga tcgacttgga ctagaaattc gaaaaattta tggtgagaaa ttgcagttta    600

ttttcactaa tattgaccct aagaatcctg agagcccatt tatgttttcc ttacatctca    660

atgaagcaag ggactatgaa gtgtcagata gtgcccctca tcttgagggc ctagcagaat    720

ttcaagagaa tgtaaggaag accaacaatt tttcagcttt tcttgccaat gttcggaaag    780

cttttactgc cacggtttat aattaacata caaatagtgt atataaaaac ggtttatttt    840

tcttctctat tacatatctc tttttttctt gtttttatta ttattatact ttaagtttta    900

gggtacatgt gcacaatgtg caggtttgtt acatatgtat acatgtgcca tattggtgtg    960

ctgcacccat taactcgtca tttcattagg tatatctcct aatgctatcc ctcccccctc   1020

ccccaaccca caacagtccc cgttgtgtga tgttcccctt cctgtgtcca tgtgttctca   1080

ttgttcaatt cccacctagg agtgagaata tgtggtgttt ggttttttgt cctttcgata   1140

gtttgctgag aatgatggtt tccagcttca tccatgttcc tacaaaggac atgaactcat   1200

ccttttttat ggctgcatag tattccatgg tgtatatgtg ccacattttc ttaatccagt   1260

ctatcattgt tggacatttg ggttggttcc aagtctttgc tattgtgaat agtgccgaaa   1320

taaacatacg tgtgcatgtg tctttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa        1375


<210>  664
<211>  224
<212>  PRT
<213>  Homosapiens

<400>  664

Met Val Glu Asp Glu Leu Ala Leu Phe Asp Lys Ser Ile Asn Glu Phe 
1               5                   10                  15      


Trp Asn Lys Phe Lys Ser Thr Asp Thr Ser Cys Gln Met Ala Gly Leu 
            20                  25                  30          


Arg Asp Thr Tyr Lys Asp Ser Ile Lys Ala Phe Ala Glu Lys Leu Ser 
        35                  40                  45              


Val Lys Leu Lys Glu Glu Glu Arg Met Val Glu Met Phe Leu Glu Tyr 
    50                  55                  60                  


Gln Asn Gln Ile Ser Arg Gln Asn Lys Leu Ile Gln Glu Lys Lys Asp 
65                  70                  75                  80  


Asn Leu Leu Lys Leu Ile Ala Glu Val Lys Gly Lys Lys Gln Glu Leu 
                85                  90                  95      


Glu Val Leu Thr Ala Asn Ile Gln Asp Leu Lys Glu Glu Tyr Ser Arg 
            100                 105                 110         


Lys Lys Glu Thr Ile Ser Thr Ala Asn Lys Ala Asn Ala Glu Arg Leu 
        115                 120                 125             


Lys Arg Leu Gln Lys Ser Ala Asp Leu Tyr Lys Asp Arg Leu Gly Leu 
    130                 135                 140                 


Glu Ile Arg Lys Ile Tyr Gly Glu Lys Leu Gln Phe Ile Phe Thr Asn 
145                 150                 155                 160 


Ile Asp Pro Lys Asn Pro Glu Ser Pro Phe Met Phe Ser Leu His Leu 
                165                 170                 175     


Asn Glu Ala Arg Asp Tyr Glu Val Ser Asp Ser Ala Pro His Leu Glu 
            180                 185                 190         


Gly Leu Ala Glu Phe Gln Glu Asn Val Arg Lys Thr Asn Asn Phe Ser 
        195                 200                 205             


Ala Phe Leu Ala Asn Val Arg Lys Ala Phe Thr Ala Thr Val Tyr Asn 
    210                 215                 220                 


<210>  665
<211>  1068
<212>  DNA
<213>  Homosapiens

<400>  665
atggatttcc ttcacaggaa tggagtgctc ataattcagc atttgcagaa ggactaccga     60

gcttactaca cttttctaaa ttttatgtcc aatgttggag accccaggaa tatctttttc    120

atttattttc cactttgttt tcaatttaat cagacagttg gaaccaagat gatatgggta    180

gcagtcattg gggattggtt aaatcttata tttaaatgga tattatttgg tcatcgacct    240

tactggtggg tccaagaaac tcagatttac ccaaatcact caagtccatg ccttgaacag    300

ttccctacta catgtgaaac aggtccagga agtccatctg gccatgcaat gggcgcatcc    360

tgtgtctggt atgtcatggt aaccgctgcc ctgagccaca ctgtctgtgg gatggataag    420

ttctctatca ctctgcacag actgacctgg tcatttcttt ggagtgtttt ttggttgatt    480

caaatcagtg tctgcatctc cagagtattc atagcaacac attttcctca tcaagttatt    540

cttggagtaa ttggtggcat gctggtggca gaggcctttg aacacactcc aggcatccaa    600

acggccagtc tgggcacata cctgaagacc aacctctttc tcttcctgtt tgcagttggc    660

ttttacctgc ttcttagggt gctcaacatt gacctgctgt ggtccgtgcc catagccaaa    720

aagtggtgtg ctaaccccga ctggatccac attgacacca cgccttttgc tggactcgtg    780

agaaaccttg gggtcctctt tggcttgggc tttgcaatca actcagagat gttcctcctg    840

agctgccgag ggggaaataa ctacacactg agcttccggt tgctctgtgc cttgacctca    900

ttgacaatac tgcagctcta ccatttcctc cagatcccga ctcacgaaga gcatttattt    960

tatgtgctgt ctttttgtaa aagtgcatcc attcccctaa ctgtggttgc tttcattccc   1020

tactctgttc atatgttaat gaaacaaagc ggaaagaaga gtcagtag                1068


<210>  666
<211>  355
<212>  PRT
<213>  Homosapiens

<400>  666

Met Asp Phe Leu His Arg Asn Gly Val Leu Ile Ile Gln His Leu Gln 
1               5                   10                  15      


Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val 
            20                  25                  30          


Gly Asp Pro Arg Asn Ile Phe Phe Ile Tyr Phe Pro Leu Cys Phe Gln 
        35                  40                  45              


Phe Asn Gln Thr Val Gly Thr Lys Met Ile Trp Val Ala Val Ile Gly 
    50                  55                  60                  


Asp Trp Leu Asn Leu Ile Phe Lys Trp Ile Leu Phe Gly His Arg Pro 
65                  70                  75                  80  


Tyr Trp Trp Val Gln Glu Thr Gln Ile Tyr Pro Asn His Ser Ser Pro 
                85                  90                  95      


Cys Leu Glu Gln Phe Pro Thr Thr Cys Glu Thr Gly Pro Gly Ser Pro 
            100                 105                 110         


Ser Gly His Ala Met Gly Ala Ser Cys Val Trp Tyr Val Met Val Thr 
        115                 120                 125             


Ala Ala Leu Ser His Thr Val Cys Gly Met Asp Lys Phe Ser Ile Thr 
    130                 135                 140                 


Leu His Arg Leu Thr Trp Ser Phe Leu Trp Ser Val Phe Trp Leu Ile 
145                 150                 155                 160 


Gln Ile Ser Val Cys Ile Ser Arg Val Phe Ile Ala Thr His Phe Pro 
                165                 170                 175     


His Gln Val Ile Leu Gly Val Ile Gly Gly Met Leu Val Ala Glu Ala 
            180                 185                 190         


Phe Glu His Thr Pro Gly Ile Gln Thr Ala Ser Leu Gly Thr Tyr Leu 
        195                 200                 205             


Lys Thr Asn Leu Phe Leu Phe Leu Phe Ala Val Gly Phe Tyr Leu Leu 
    210                 215                 220                 


Leu Arg Val Leu Asn Ile Asp Leu Leu Trp Ser Val Pro Ile Ala Lys 
225                 230                 235                 240 


Lys Trp Cys Ala Asn Pro Asp Trp Ile His Ile Asp Thr Thr Pro Phe 
                245                 250                 255     


Ala Gly Leu Val Arg Asn Leu Gly Val Leu Phe Gly Leu Gly Phe Ala 
            260                 265                 270         


Ile Asn Ser Glu Met Phe Leu Leu Ser Cys Arg Gly Gly Asn Asn Tyr 
        275                 280                 285             


Thr Leu Ser Phe Arg Leu Leu Cys Ala Leu Thr Ser Leu Thr Ile Leu 
    290                 295                 300                 


Gln Leu Tyr His Phe Leu Gln Ile Pro Thr His Glu Glu His Leu Phe 
305                 310                 315                 320 


Tyr Val Leu Ser Phe Cys Lys Ser Ala Ser Ile Pro Leu Thr Val Val 
                325                 330                 335     


Ala Phe Ile Pro Tyr Ser Val His Met Leu Met Lys Gln Ser Gly Lys 
            340                 345                 350         


Lys Ser Gln 
        355 


<210>  667
<211>  4775
<212>  DNA
<213>  Homosapiens

<400>  667
gaatgatgaa aaccgaggtt ggaaaaggtt gtgaaacctt ttaactctcc acagtggagt     60

ccattatttc ctctggcttc ctcaaattca tattcacagg gtcgttggct gtgggttgca    120

attaccatgt ctgactcagt aattcttcga agtataaaga aatttggaga ggagaatgat    180

ggttttgagt cagataaatc atataataat gataagaaat caaggttaca agatgagaag    240

aaaggtgatg gcgttagagt tggcttcttt caattgtttc ggttttcttc atcaactgac    300

atttggctga tgtttgtggg aagtttgtgt gcatttctcc atggaatagc ccagccaggc    360

gtgctactca tttttggcac aatgacagat gtttttattg actacgacgt tgagttacaa    420

gaactccaga ttccaggaaa agcatgtgtg aataacacca ttgtatggac taacagttcc    480

ctcaaccaga acatgacaaa tggaacacgt tgtgggttgc tgaacatcga gagcgaaatg    540

atcaaatttg ccagttacta tgctggaatt gctgtcgcag tacttatcac aggatatatt    600

caaatatgct tttgggtcat tgccgcagct cgtcagatac agaaaatgag aaaattttac    660

tttaggagaa taatgagaat ggaaataggg tggtttgact gcaattcagt gggggagctg    720

aatacaagat tctctgatga tattaataaa atcaatgatg ccatagctga ccaaatggcc    780

cttttcattc agcgcatgac ctcgaccatc tgtggtttcc tgttgggatt tttcaggggt    840

tggaaactga ccttggttat tatttctgtc agccctctca ttgggattgg agcagccacc    900

attggtctga gtgtgtccaa gtttacggac tatgagctga aggcctatgc caaagcaggg    960

gtggtggctg atgaagtcat ttcatcaatg agaacagtgg ctgcttttgg tggtgagaaa   1020

agagaggttg aaaggtatga gaaaaatctt gtgttcgccc agcgttgggg aattagaaaa   1080

ggaatagtga tgggattctt tactggattc gtgtggtgtc tcatcttttt gtgttatgca   1140

ctggccttct ggtacggctc cacacttgtc ctggatgaag gagaatatac accaggaacc   1200

cttgtccaga ttttcctcag tgtcatagta ggagctttaa atcttggcaa tgcctctcct   1260

tgtttggaag cctttgcaac tggacgtgca gcagccacca gcatttttga gacaatagac   1320

aggaaaccca tcattgactg catgtcagaa gatggttaca agttggatcg aatcaagggt   1380

gaaattgaat tccataatgt gaccttccat tatccttcca gaccagaggt gaagattcta   1440

aatgacctca acatggtcat taaaccaggg gaaatgacag ctctggtagg acccagtgga   1500

gctggaaaaa gtacagcact gcaactcatt cagcgattct atgacccctg tgaaggaatg   1560

gtgaccgtgg atggccatga cattcgctct cttaacattc agtggcttag agatcagatt   1620

gggatagtgg agcaagagcc agttctgttc tctaccacca ttgcagaaaa tattcgctat   1680

ggcagagaag atgcaacaat ggaagacata gtccaagctg ccaaggaggc caatgcctac   1740

aacttcatca tggacctgcc acagcaattt gacacccttg ttggagaagg aggaggccag   1800

atgagtggtg gccagaaaca aagggtagct atcgccagag ccctcatccg aaatcccaag   1860

attctgcttt tggacatggc cacctcagct ctggacaatg agagtgaagc catggtgcaa   1920

gaagtgctga gtaagattca gcatgggcac acaatcattt cagttgctca tcgcttgtct   1980

acggtcagag ctgcagatac catcattggt tttgaacatg gcactgcagt ggaaagaggg   2040

acccatgaag aattactgga aaggaaaggt gtttacttca ctctagtgac tttgcaaagc   2100

cagggaaatc aagctcttaa tgaagaggac ataaaggatg caactgaaga tgacatgctt   2160

gcgaggacct ttagcagagg gagctaccag gatagtttaa gggcttccat ccggcaacgc   2220

tccaagtctc agctttctta cctggtgcac gaacctccat tagctgttgt agatcataag   2280

tctacctatg aagaagatag aaaggacaag gacattcctg tgcaggaaga agttgaacct   2340

gccccagtta ggaggattct gaaattcagt gctccagaat ggccctacat gctggtaggg   2400

tctgtgggtg cagctgtgaa cgggacagtc acacccttgt atgccttttt attcagccag   2460

attcttggga ctttttcaat tcctgataaa gaggaacaaa ggtcacagat caatggtgtg   2520

tgcctacttt ttgtagcaat gggctgtgta tctcttttca cccaatttct acagggatat   2580

gcctttgcta aatctgggga gctcctaaca aaaaggctac gtaaatttgg tttcagggca   2640

atgctggggc aagatattgc ctggtttgat gacctcagaa atagccctgg agcattgaca   2700

acaagacttg ctacagatgc ttcccaagtt caaggggctg ccggctctca gatcgggatg   2760

atagtcaatt ccttcactaa cgtcactgtg gccatgatca ttgccttctc ctttagctgg   2820

aagctgagcc tggtcatctt gtgcttcttc cccttcttgg ctttatcagg agccacacag   2880

accaggatgt tgacaggatt tgcctctcga gataagcagg ccctggagat ggtgggacag   2940

attacaaatg aagccctcag taacatccgc actgttgctg gaattggaaa ggagaggcgg   3000

ttcattgaag cacttgagac tgagctggag aagcccttca agacagccat tcagaaagcc   3060

aatatttacg gattctgctt tgcctttgcc cagtgcatca tgtttattgc gaattctgct   3120

tcctacagat atggaggtta cttaatctcc aatgaggggc tccatttcag ctatgtgttc   3180

agggtgatct ctgcagttgt actgagtgca acagctcttg gaagagcctt ctcttacacc   3240

ccaagttatg caaaagctaa aatatcagct gcacgctttt ttcaactgct ggaccgacaa   3300

cccccaatca gtgtatacaa tactgcaggt gaaaaatggg acaacttcca ggggaagatt   3360

gattttgttg attgtaaatt tacatatcct tctcgacctg actcgcaagt tctgaatggt   3420

ctctcagtgt cgattagtcc agggcagaca ctggcgtttg ttgggagcag tggatgtggc   3480

aaaagcacta gcattcagct gttggaacgt ttctatgatc ctgatcaagg gaaggtgatg   3540

atagatggtc atgacagcaa aaaagtaaat gtccagttcc tccgctcaaa cattggaatt   3600

gtttcccagg aaccagtgtt gtttgcctgt agcataatgg acaatatcaa gtatggagac   3660

aacaccaaag aaattcccat ggaaagagtc atagcagctg caaaacaggc tcagctgcat   3720

gattttgtca tgtcactccc agagaaatat gaaactaacg ttgggtccca ggggtctcaa   3780

ctctctagag gggagaaaca acgcattgct attgctcggg ccattgtacg agatcctaaa   3840

atcttgctac tagatgaagc cacttctgcc ttagacacag aaagtgaaaa gacggtgcag   3900

gttgctctag acaaagccag agagggtcgg acctgcattg tcattgccca tcgcttgtcc   3960

accatccaga acgcggatat cattgctgtc atggcacagg gggtggtgat tgaaaagggg   4020

acccatgaag aactgatggc ccaaaaagga gcctactaca aactagtcac cactggatcc   4080

cccatcagtt gacccaatgc aagaatctca gacacacatg acgcaccagt tacaggggtt   4140

gtttttaaag aaaaaaacaa tcccagcagg agggattgct gggattgttt tttctttaaa   4200

gaagaatgtt aatattttac ttttacagtc attttcctac atcggaatcc aagctaattt   4260

ctaatggcct tccataataa ttctgcttta gatgtgtata cagaaaatga aagaaactag   4320

ggtccatatg agggaaaacc caatgtcaag tggcagctca gccaccactc agtgcttctc   4380

tgtgcaggag ccagtcctga ttaatatgtg ggaattagtg agacatcagg gagtaagtga   4440

cactttgaac tcctcaaggg cagagaactg tctttcattt ttgaaccctc ggtgtacaca   4500

gaggcgggtc tataacaggc aatcaacaaa cgtttcttga gctagaccaa ggtcagattt   4560

gaaaagaaca gaaggactga agaccagctg tgtttcttaa ctaaatttgt ctttcaagtg   4620

aaaccagctt ccttcatctc taaggctaag gatagggaaa gggtggatgc tctcaggctg   4680

agggaggcag aaagggaaag tattagcatg agctttccag ttagggctgt tgatttatgc   4740

tttaacttca gagtgagtgt aggggtggtg atgct                              4775


<210>  668
<211>  1321
<212>  PRT
<213>  Homosapiens

<400>  668

Met Ser Asp Ser Val Ile Leu Arg Ser Ile Lys Lys Phe Gly Glu Glu 
1               5                   10                  15      


Asn Asp Gly Phe Glu Ser Asp Lys Ser Tyr Asn Asn Asp Lys Lys Ser 
            20                  25                  30          


Arg Leu Gln Asp Glu Lys Lys Gly Asp Gly Val Arg Val Gly Phe Phe 
        35                  40                  45              


Gln Leu Phe Arg Phe Ser Ser Ser Thr Asp Ile Trp Leu Met Phe Val 
    50                  55                  60                  


Gly Ser Leu Cys Ala Phe Leu His Gly Ile Ala Gln Pro Gly Val Leu 
65                  70                  75                  80  


Leu Ile Phe Gly Thr Met Thr Asp Val Phe Ile Asp Tyr Asp Val Glu 
                85                  90                  95      


Leu Gln Glu Leu Gln Ile Pro Gly Lys Ala Cys Val Asn Asn Thr Ile 
            100                 105                 110         


Val Trp Thr Asn Ser Ser Leu Asn Gln Asn Met Thr Asn Gly Thr Arg 
        115                 120                 125             


Cys Gly Leu Leu Asn Ile Glu Ser Glu Met Ile Lys Phe Ala Ser Tyr 
    130                 135                 140                 


Tyr Ala Gly Ile Ala Val Ala Val Leu Ile Thr Gly Tyr Ile Gln Ile 
145                 150                 155                 160 


Cys Phe Trp Val Ile Ala Ala Ala Arg Gln Ile Gln Lys Met Arg Lys 
                165                 170                 175     


Phe Tyr Phe Arg Arg Ile Met Arg Met Glu Ile Gly Trp Phe Asp Cys 
            180                 185                 190         


Asn Ser Val Gly Glu Leu Asn Thr Arg Phe Ser Asp Asp Ile Asn Lys 
        195                 200                 205             


Ile Asn Asp Ala Ile Ala Asp Gln Met Ala Leu Phe Ile Gln Arg Met 
    210                 215                 220                 


Thr Ser Thr Ile Cys Gly Phe Leu Leu Gly Phe Phe Arg Gly Trp Lys 
225                 230                 235                 240 


Leu Thr Leu Val Ile Ile Ser Val Ser Pro Leu Ile Gly Ile Gly Ala 
                245                 250                 255     


Ala Thr Ile Gly Leu Ser Val Ser Lys Phe Thr Asp Tyr Glu Leu Lys 
            260                 265                 270         


Ala Tyr Ala Lys Ala Gly Val Val Ala Asp Glu Val Ile Ser Ser Met 
        275                 280                 285             


Arg Thr Val Ala Ala Phe Gly Gly Glu Lys Arg Glu Val Glu Arg Tyr 
    290                 295                 300                 


Glu Lys Asn Leu Val Phe Ala Gln Arg Trp Gly Ile Arg Lys Gly Ile 
305                 310                 315                 320 


Val Met Gly Phe Phe Thr Gly Phe Val Trp Cys Leu Ile Phe Leu Cys 
                325                 330                 335     


Tyr Ala Leu Ala Phe Trp Tyr Gly Ser Thr Leu Val Leu Asp Glu Gly 
            340                 345                 350         


Glu Tyr Thr Pro Gly Thr Leu Val Gln Ile Phe Leu Ser Val Ile Val 
        355                 360                 365             


Gly Ala Leu Asn Leu Gly Asn Ala Ser Pro Cys Leu Glu Ala Phe Ala 
    370                 375                 380                 


Thr Gly Arg Ala Ala Ala Thr Ser Ile Phe Glu Thr Ile Asp Arg Lys 
385                 390                 395                 400 


Pro Ile Ile Asp Cys Met Ser Glu Asp Gly Tyr Lys Leu Asp Arg Ile 
                405                 410                 415     


Lys Gly Glu Ile Glu Phe His Asn Val Thr Phe His Tyr Pro Ser Arg 
            420                 425                 430         


Pro Glu Val Lys Ile Leu Asn Asp Leu Asn Met Val Ile Lys Pro Gly 
        435                 440                 445             


Glu Met Thr Ala Leu Val Gly Pro Ser Gly Ala Gly Lys Ser Thr Ala 
    450                 455                 460                 


Leu Gln Leu Ile Gln Arg Phe Tyr Asp Pro Cys Glu Gly Met Val Thr 
465                 470                 475                 480 


Val Asp Gly His Asp Ile Arg Ser Leu Asn Ile Gln Trp Leu Arg Asp 
                485                 490                 495     


Gln Ile Gly Ile Val Glu Gln Glu Pro Val Leu Phe Ser Thr Thr Ile 
            500                 505                 510         


Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asp Ala Thr Met Glu Asp Ile 
        515                 520                 525             


Val Gln Ala Ala Lys Glu Ala Asn Ala Tyr Asn Phe Ile Met Asp Leu 
    530                 535                 540                 


Pro Gln Gln Phe Asp Thr Leu Val Gly Glu Gly Gly Gly Gln Met Ser 
545                 550                 555                 560 


Gly Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ile Arg Asn 
                565                 570                 575     


Pro Lys Ile Leu Leu Leu Asp Met Ala Thr Ser Ala Leu Asp Asn Glu 
            580                 585                 590         


Ser Glu Ala Met Val Gln Glu Val Leu Ser Lys Ile Gln His Gly His 
        595                 600                 605             


Thr Ile Ile Ser Val Ala His Arg Leu Ser Thr Val Arg Ala Ala Asp 
    610                 615                 620                 


Thr Ile Ile Gly Phe Glu His Gly Thr Ala Val Glu Arg Gly Thr His 
625                 630                 635                 640 


Glu Glu Leu Leu Glu Arg Lys Gly Val Tyr Phe Thr Leu Val Thr Leu 
                645                 650                 655     


Gln Ser Gln Gly Asn Gln Ala Leu Asn Glu Glu Asp Ile Lys Asp Ala 
            660                 665                 670         


Thr Glu Asp Asp Met Leu Ala Arg Thr Phe Ser Arg Gly Ser Tyr Gln 
        675                 680                 685             


Asp Ser Leu Arg Ala Ser Ile Arg Gln Arg Ser Lys Ser Gln Leu Ser 
    690                 695                 700                 


Tyr Leu Val His Glu Pro Pro Leu Ala Val Val Asp His Lys Ser Thr 
705                 710                 715                 720 


Tyr Glu Glu Asp Arg Lys Asp Lys Asp Ile Pro Val Gln Glu Glu Val 
                725                 730                 735     


Glu Pro Ala Pro Val Arg Arg Ile Leu Lys Phe Ser Ala Pro Glu Trp 
            740                 745                 750         


Pro Tyr Met Leu Val Gly Ser Val Gly Ala Ala Val Asn Gly Thr Val 
        755                 760                 765             


Thr Pro Leu Tyr Ala Phe Leu Phe Ser Gln Ile Leu Gly Thr Phe Ser 
    770                 775                 780                 


Ile Pro Asp Lys Glu Glu Gln Arg Ser Gln Ile Asn Gly Val Cys Leu 
785                 790                 795                 800 


Leu Phe Val Ala Met Gly Cys Val Ser Leu Phe Thr Gln Phe Leu Gln 
                805                 810                 815     


Gly Tyr Ala Phe Ala Lys Ser Gly Glu Leu Leu Thr Lys Arg Leu Arg 
            820                 825                 830         


Lys Phe Gly Phe Arg Ala Met Leu Gly Gln Asp Ile Ala Trp Phe Asp 
        835                 840                 845             


Asp Leu Arg Asn Ser Pro Gly Ala Leu Thr Thr Arg Leu Ala Thr Asp 
    850                 855                 860                 


Ala Ser Gln Val Gln Gly Ala Ala Gly Ser Gln Ile Gly Met Ile Val 
865                 870                 875                 880 


Asn Ser Phe Thr Asn Val Thr Val Ala Met Ile Ile Ala Phe Ser Phe 
                885                 890                 895     


Ser Trp Lys Leu Ser Leu Val Ile Leu Cys Phe Phe Pro Phe Leu Ala 
            900                 905                 910         


Leu Ser Gly Ala Thr Gln Thr Arg Met Leu Thr Gly Phe Ala Ser Arg 
        915                 920                 925             


Asp Lys Gln Ala Leu Glu Met Val Gly Gln Ile Thr Asn Glu Ala Leu 
    930                 935                 940                 


Ser Asn Ile Arg Thr Val Ala Gly Ile Gly Lys Glu Arg Arg Phe Ile 
945                 950                 955                 960 


Glu Ala Leu Glu Thr Glu Leu Glu Lys Pro Phe Lys Thr Ala Ile Gln 
                965                 970                 975     


Lys Ala Asn Ile Tyr Gly Phe Cys Phe Ala Phe Ala Gln Cys Ile Met 
            980                 985                 990         


Phe Ile Ala Asn Ser Ala Ser Tyr  Arg Tyr Gly Gly Tyr  Leu Ile Ser 
        995                 1000                 1005             


Asn Glu  Gly Leu His Phe Ser  Tyr Val Phe Arg Val  Ile Ser Ala 
    1010                 1015                 1020             


Val Val  Leu Ser Ala Thr Ala  Leu Gly Arg Ala Phe  Ser Tyr Thr 
    1025                 1030                 1035             


Pro Ser  Tyr Ala Lys Ala Lys  Ile Ser Ala Ala Arg  Phe Phe Gln 
    1040                 1045                 1050             


Leu Leu  Asp Arg Gln Pro Pro  Ile Ser Val Tyr Asn  Thr Ala Gly 
    1055                 1060                 1065             


Glu Lys  Trp Asp Asn Phe Gln  Gly Lys Ile Asp Phe  Val Asp Cys 
    1070                 1075                 1080             


Lys Phe  Thr Tyr Pro Ser Arg  Pro Asp Ser Gln Val  Leu Asn Gly 
    1085                 1090                 1095             


Leu Ser  Val Ser Ile Ser Pro  Gly Gln Thr Leu Ala  Phe Val Gly 
    1100                 1105                 1110             


Ser Ser  Gly Cys Gly Lys Ser  Thr Ser Ile Gln Leu  Leu Glu Arg 
    1115                 1120                 1125             


Phe Tyr  Asp Pro Asp Gln Gly  Lys Val Met Ile Asp  Gly His Asp 
    1130                 1135                 1140             


Ser Lys  Lys Val Asn Val Gln  Phe Leu Arg Ser Asn  Ile Gly Ile 
    1145                 1150                 1155             


Val Ser  Gln Glu Pro Val Leu  Phe Ala Cys Ser Ile  Met Asp Asn 
    1160                 1165                 1170             


Ile Lys  Tyr Gly Asp Asn Thr  Lys Glu Ile Pro Met  Glu Arg Val 
    1175                 1180                 1185             


Ile Ala  Ala Ala Lys Gln Ala  Gln Leu His Asp Phe  Val Met Ser 
    1190                 1195                 1200             


Leu Pro  Glu Lys Tyr Glu Thr  Asn Val Gly Ser Gln  Gly Ser Gln 
    1205                 1210                 1215             


Leu Ser  Arg Gly Glu Lys Gln  Arg Ile Ala Ile Ala  Arg Ala Ile 
    1220                 1225                 1230             


Val Arg  Asp Pro Lys Ile Leu  Leu Leu Asp Glu Ala  Thr Ser Ala 
    1235                 1240                 1245             


Leu Asp  Thr Glu Ser Glu Lys  Thr Val Gln Val Ala  Leu Asp Lys 
    1250                 1255                 1260             


Ala Arg  Glu Gly Arg Thr Cys  Ile Val Ile Ala His  Arg Leu Ser 
    1265                 1270                 1275             


Thr Ile  Gln Asn Ala Asp Ile  Ile Ala Val Met Ala  Gln Gly Val 
    1280                 1285                 1290             


Val Ile  Glu Lys Gly Thr His  Glu Glu Leu Met Ala  Gln Lys Gly 
    1295                 1300                 1305             


Ala Tyr  Tyr Lys Leu Val Thr  Thr Gly Ser Pro Ile  Ser 
    1310                 1315                 1320     


<210>  669
<211>  2939
<212>  DNA
<213>  Homosapiens

<400>  669
atctgaaaaa ttaataattc cttaattatc aaatatccat tatttaaatt tataattgtg     60

tcataaatat tgtcataaat agatttgctg ttttaaagct tgttccttca ttttctctgt    120

tttgttttag ataaacattg tcataaatag atttgttgtt ttaaagcttg ttccttcatt    180

ttctctgatt gttttgtttt agattcagag gttacttatg cttgtttgtt acatggatgt    240

tacatgtgta atgggggata ttggacttct agtgtactca tcacccatat actgaacact    300

gtactcaaaa gggattgaaa gaaactagga aacttggcag gaagatcatt cttaagccag    360

gaaaaaaatt tttaatgctc acatgtgaac atgtgatggt cataccagaa ggagcaccca    420

cctccctccc tctgtgacag acacattttc ttagccttca cctttccttc tttcaagttg    480

ctgaaaatcc acagtgtttc tgttcatttg ttactttcat tctcacctat cttctctctt    540

gctccatcta ccagaacaat aattccccat ataatacttc tcacttcact tttcaacgca    600

ggacctcttg ttggtctgat ctgtttgtct gtccgcttta tcaatattat cagatgtaag    660

tttacatgaa tacacacaca tattcactaa actgagggga aaaaatgcct tgtaggtcat    720

aaaaaagcag ggaaattccc aacaattcat atttgatccc tggatccagg ggtggcagca    780

ataagcctgc tttagatatt tactccccat tttatgatcc ggtggtttgg tttttcaaat    840

gatgatatgg ctcctttcgc aatgacttga tgtttaggag gtgtgcttca ataaatacat    900

tttaaaatca acaatcaagt tagagttgta caaatggctc tgaaatgtcc cactacactg    960

ttagaccaag ggcacagatt gtgcttctgt actatttatc ctagtatccc tcggcatata   1020

ttaactgctc taaaaatctc cttggctaca cgctgcatca aatcaaagtt aaatgttata   1080

ccacctttct attctatttt taatattcaa agagggtgct cagattttag aacaaatttc   1140

aatgtttaag tacacacaaa aaaatcatta actcatatat ttcaagagta ggaaatggga   1200

actggtgtta aaactcttat aacaaatgtc actgtcttaa gggacagtgt ttaaaaacgc   1260

atacctggcc gggcgcggtg gctcatgcct gtaatcccag cactttggga ggccgaggcc   1320

ggcggatcac aaggaaaaca aactcaggaa gaaaaaggaa agcagaagtg atcaaggaga   1380

gcgctcgagt tgcaatattt tcctttggct gctgacaggc agttactata aagcattgtg   1440

catggacacc atcttcttgt attatacaag aaaggagtgt acctatcaca cacaggggga   1500

aaaatgctct tttgggtgct aggcctccta atcctctgtg gttttctgtg gactcgtaaa   1560

ggaaaactaa agattgaaga catcactgat aagtacattt ttatcactgg atgtgactcg   1620

ggctttggaa acttggcagc cagaactttt gataaaaagg gatttcatgt aatcgctgcc   1680

tgtctgactg aatcaggatc aacagcttta aaggcagaaa cctcagagag acttcgtact   1740

gtgcttctgg atgtgaccga cccagagaat gtcaagagga ctgcccagtg ggtgaagaac   1800

caagttgggg agaaaggtct ctggggtctg atcaataatg ctggtgttcc cggcgtgctg   1860

gctcccactg actggctgac actagaggac tacagagaac ctattgaagt gaacctgttt   1920

ggactcatca gtgtgacact aaatatgctt cctttggtca agaaagctca agggagagtt   1980

attaatgtct ccagtgttgg aggtcgcctt gcaatcgttg gagggggcta tactccatcc   2040

aaatatgcag tggaaggttt caatgacagc ttaagacggg acatgaaagc ttttggtgtg   2100

cacgtctcat gcattgaacc aggattgttc aaaacaaact tggcagatcc agtaaaggta   2160

attgaaaaaa aactcgccat ttgggagcag ctgtctccag acatcaaaca acaatatgga   2220

gaaggttaca ttgaaaaaag tctagacaaa ctgaaaggca ataaatccta tgtgaacatg   2280

gacctctctc cggtggtaga gtgcatggac cacgctctaa caagtctctt ccctaagact   2340

cattatgccg ctggaaaaga tgccaaaatt ttctggatac ctctgtctca catgccagca   2400

gctttgcaag actttttatt gttgaaacag aaagcagagc tggctaatcc caaggcagtg   2460

tgactcagct aaccacaaat gtctcctcca ggctatgaaa ttggccgatt tcaagaacac   2520

atctcctttt caaccccatt ccttatctgc tccaacctgg actcatttag atcgtgctta   2580

tttggattgc aaaagggagt cccaccatcg ctggtggtat cccagggtcc ctgctcaagt   2640

tttctttgaa aaggagggct ggaatggtac atcacatagg caagtcctgc cctgtattta   2700

ggctttgcct gcttggtgtg atgtaaggga aattgaaaga cttgcccatt caaaatgatc   2760

tttaccgtgg cctgccccat gcttatggtc cccagcattt acagtaactt gtgaatgtta   2820

agtatcatct cttatctaaa tattaaaaga taagtcaaac attaaaaaaa aaaaaaaaaa   2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa    2939


<210>  670
<211>  319
<212>  PRT
<213>  Homosapiens

<400>  670

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  671
<211>  1993
<212>  DNA
<213>  Homosapiens

<400>  671
aggaagaaaa tataaagtac acttttaaaa catgaagtct tcatagcagc ttatagtcgt     60

tcagagaaac atgttccact gagaatgact tgagagagag gattacatca ttatgccaga    120

aggaagaagc cactgtgcat gctctatcac cagcctcacc ctcctggtca gccttacaag    180

agtgacactg gatatactcc agaagttgga cccaccacag cctgcacact ggacttcttg    240

gcttttatga gctattcaag agatatttag tcatcacgtt gtgtcacaat gggagtgact    300

cacagagcaa ggagagaacc tgaggattcc tcacacatgt agtactcaga gctctacgga    360

aacccaggca cctcgacctc aagaggatca gcctggccag ggtggcacaa ctcttccttc    420

cccgtgcaca gcaggaaagc tgccatcagc tgagcaagtc caccaacagt ttctgtgtcc    480

cacttcatct ttaataagga caccatcttc ttgtattata caagaaagga gtgtacctat    540

cacacacagg gggaaaaatg ctcttttggg tgctaggcct cctaatcctc tgtggttttc    600

tgtggactcg taaaggaaaa ctaaagattg aagacatcac tgataagtac atttttatca    660

ctggatgtga ctcgggcttt ggaaacttgg cagccagaac ttttgataaa aagggatttc    720

atgtaatcgc tgcctgtctg actgaatcag gatcaacagc tttaaaggca gaaacctcag    780

agagacttcg tactgtgctt ctggatgtga ccgacccaga gaatgtcaag aggactgccc    840

agtgggtgaa gaaccaagtt ggggagaaag gtctctgggg tctgatcaat aatgctggtg    900

ttcccggcgt gctggctccc actgactggc tgacactaga ggactacaga gaacctattg    960

aagtgaacct gtttggactc atcagtgtga cactaaatat gcttcctttg gtcaagaaag   1020

ctcaagggag agttattaat gtctccagtg ttggaggtcg ccttgcaatc gttggagggg   1080

gctatactcc atccaaatat gcagtggaag gtttcaatga cagcttaaga cgggacatga   1140

aagcttttgg tgtgcacgtc tcatgcattg aaccaggatt gttcaaaaca aacttggcag   1200

atccagtaaa ggtaattgaa aaaaaactcg ccatttggga gcagctgtct ccagacatca   1260

aacaacaata tggagaaggt tacattgaaa aaagtctaga caaactgaaa ggcaataaat   1320

cctatgtgaa catggacctc tctccggtgg tagagtgcat ggaccacgct ctaacaagtc   1380

tcttccctaa gactcattat gccgctggaa aagatgccaa aattttctgg atacctctgt   1440

ctcacatgcc agcagctttg caagactttt tattgttgaa acagaaagca gagctggcta   1500

atcccaaggc agtgtgactc agctaaccac aaatgtctcc tccaggctat gaaattggcc   1560

gatttcaaga acacatctcc ttttcaaccc cattccttat ctgctccaac ctggactcat   1620

ttagatcgtg cttatttgga ttgcaaaagg gagtcccacc atcgctggtg gtatcccagg   1680

gtccctgctc aagttttctt tgaaaaggag ggctggaatg gtacatcaca taggcaagtc   1740

ctgccctgta tttaggcttt gcctgcttgg tgtgatgtaa gggaaattga aagacttgcc   1800

cattcaaaat gatctttacc gtggcctgcc ccatgcttat ggtccccagc atttacagta   1860

acttgtgaat gttaagtatc atctcttatc taaatattaa aagataagtc aaacattaaa   1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1980

aaaaaaaaaa aaa                                                      1993


<210>  672
<211>  319
<212>  PRT
<213>  Homosapiens

<400>  672

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  673
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  673
gcagacctaa aggagcgttc gctagcagag gcgctgccgg tgcggtgtgc tacgcgcgcc     60

cacctcccgg ggaaggaacg gcgaggccgg ggaccgtcgc ggagatggat cgcgggccgg    120

cagcagtggc gtgcacgctg ctcctggctc tcgtcgcctg cctagcgccg gccagtggcc    180

aagaatgtga cagtgcgcat tttcgctgtg gaagtgggca ttgcatccct gcagactgga    240

ggtgtgatgg gaccaaagac tgttcagatg acgcggatga aattggctgc gctgttgtga    300

cctgccagca gggctatttc aagtgccaga gtgagggaca atgcatcccc agctcctggg    360

tgtgtgacca agatcaagac tgtgatgatg gctcagatga acgtcaagat tgctcacaaa    420

gtacatgctc aagtcatcag ataacatgct ccaatggtca gtgtatccca agtgaataca    480

ggtgcgacca cgtcagagac tgccccgatg gagctgatga gaatgactgc cagtacccaa    540

catgtgagca gcttacttgt gacaatgggg cctgctataa caccagtcag aagtgtgatt    600

ggaaagttga ttgcagggac tcctcagatg aaatcaactg cactgagata tgcttgcaca    660

atgagttttc atgtggcaat ggagagtgta tccctcgtgc ttatgtctgt gaccatgaca    720

atgattgcca agacggcagt gatgaacatg cttgcaacta tccgacctgc ggtggttacc    780

agttcacttg ccccagtggc cgatgcattt atcaaaactg ggtttgtgat ggagaagatg    840

actgtaaaga taatggagat gaagatggat gtgaaagcgg tcctcatgat gttcataaat    900

gttccccaag agaatggtct tgcccagagt cgggacgatg catctccatt tataaagttt    960

gtgatgggat tttagattgc ccaggaagag aagatgaaaa caacactagt accggaaaat   1020

actgtagtat gactctgtgc tctgccttga actgccagta ccagtgccat gagacgccgt   1080

atggaggagc gtgtttttgt cccccaggtt atatcatcaa ccacaatgac agccgtacct   1140

gtgttgagtt tgatgattgc cagatatggg gaatttgtga ccagaagtgt gaaagccgac   1200

ctggccgtca cctgtgccac tgtgaagaag ggtatatctt ggagcgtgga cagtattgca   1260

aagctaatga ttcctttggc gaggcctcca ttatcttctc caatggtcgg gatttgttaa   1320

ttggtgatat tcatggaagg agcttccgga tcctagtgga gtctcagaat cgtggagtgg   1380

ccgtgggtgt ggctttccac tatcacctgc aaagagtttt ttggacagac accgtgcaaa   1440

ataaggtttt ttcagttgac attaatggtt taaatatcca agaggttctc aatgtttctg   1500

ttgaaacccc agagaacctg gctgtggact gggttaataa taaaatctat ctagtggaaa   1560

ccaaggtcaa ccgcatagat atggtaaatt tggatggaag ctatcgggtt acccttataa   1620

ctgaaaactt ggggcatcct agaggaattg ccgtggaccc aactgttggt tatttatttt   1680

tctcagattg ggagagcctt tctggggaac ctaagctgga aagggcattc atggatggca   1740

gcaaccgtaa agacttggtg aaaacaaagc tgggatggcc tgctggggta actctggata   1800

tgatatcgaa gcgtgtttac tgggttgact ctcggtttga ttacattgaa actgtaactt   1860

atgatggaat tcaaaggaag actgtagttc atggaggctc cctcattcct catccctttg   1920

gagtaagctt atttgaaggt caggtgttct ttacagattg gacaaagatg gccgtgctga   1980

aggcaaacaa gttcacagag accaacccac aagtgtacta ccaggcttcc ctgaggccct   2040

atggagtgac tgtttaccat tccctcagac agccctatgc taccaatccg tgtaaagata   2100

acaatggggg ctgtgagcag gtctgtgttc tcagccacag aacagataat gatggtttgg   2160

gtttccgttg caagtgcaca ttcggcttcc aactggatac agatgagcgc cactgcattg   2220

ctgttcagaa tttcctcatt ttttcatccc aagttgctat tcgtgggatc ccgttcacct   2280

tgtctaccca ggaagatgtc atggttccag tttcggggaa tccttctttc tttgtcggga   2340

ttgattttga cgcccaggac agcactatct ttttttcaga tatgtcaaaa cacatgattt   2400

ttaagcaaaa gattgatggc acaggaagag aaattctcgc agctaacagg gtggaaaatg   2460

ttgaaagttt ggcttttgat tggatttcaa agaatctcta ttggacagac tctcattaca   2520

agagtatcag tgtcatgagg ctagctgata aaacgagacg cacagtagtt cagtatttaa   2580

ataacccacg gtcggtggta gttcatcctt ttgccgggta tctattcttc actgattggt   2640

tccgtcctgc taaaattatg agagcatgga gtgacggatc tcacctcttg cctgtaataa   2700

acactactct tggatggccc aatggcttgg ccatcgattg ggctgcttca cgattgtact   2760

gggtagatgc ctattttgat aaaattgagc acagcacctt tgatggttta gacagaagaa   2820

gactgggcca tatagagcag atgacacatc cgtttggact tgccatcttt ggagagcatt   2880

tattttttac tgactggaga ctgggtgcca ttattcgagt caggaaagca gatggtggag   2940

aaatgacagt tatccgaagt ggcattgctt acatactgca tttgaaatcg tatgatgtca   3000

acatccagac tggttctaac gcctgtaatc aacccacgca tcctaacggt gactgcagcc   3060

acttctgctt cccggtgcca aatttccagc gagtgtgtgg gtgcccttat ggaatgaggc   3120

tggcttccaa tcacttgaca tgcgaggggg acccaaccaa tgaaccaccc acggagcagt   3180

gtggcttatt ttccttcccc tgtaaaaatg gcagatgtgt gcccaattac tatctctgtg   3240

atggagtcga tgattgtcat gataacagtg atgagcaact atgtggcaca cttaataata   3300

cctgttcatc ttcggcgttc acctgtggcc atggggagtg cattcctgca cactggcgct   3360

gtgacaaacg caacgactgt gtggatggca gtgatgagca caactgcccc acccacgcac   3420

ctgcttcctg ccttgacacc caatacacct gtgataatca ccagtgtatc tcaaagaact   3480

gggtctgtga cacagacaat gattgtgggg atggatctga tgaaaagaac tgcaattcga   3540

cagagacatg ccaacctagt cagtttaatt gccccaatca tcgatgtatt gacctatcgt   3600

ttgtctgtga tggtgacaag gattgtgttg atggatctga tgaggttggt tgtgtattaa   3660

actgtactgc ttctcaattc aagtgtgcca gtggggataa atgtattggc gtcacaaatc   3720

gttgtgatgg tgtttttgat tgcagtgaca actcggatga agcgggctgt ccaaccaggc   3780

ctcctggtat gtgccactca gatgaatttc agtgccaaga agatggtatc tgcatcccga   3840

acttctggga atgtgatggg catccagact gcctctatgg atctgatgag cacaatgcct   3900

gtgtccccaa gacttgccct tcatcatatt tccactgtga caacggaaac tgcatccaca   3960

gggcatggct ctgtgatcgg gacaatgact gcggggatat gagtgatgag aaggactgcc   4020

ctactcagcc ctttcgctgt cctagttggc aatggcagtg tcttggccat aacatctgtg   4080

tgaatctgag tgtagtgtgt gatggcatct ttgactgccc caatgggaca gatgagtccc   4140

cactttgcaa tgggaacagc tgctcagatt tcaatggtgg ttgtactcac gagtgtgttc   4200

aagagccctt tggggctaaa tgcctatgtc cattgggatt cttacttgcc aatgattcta   4260

agacctgtga agacatagat gaatgtgata ttctaggctc ttgtagccag cactgttaca   4320

atatgagagg ttctttccgg tgctcgtgtg atacaggcta catgttagaa agtgatggga   4380

ggacttgcaa agttacagca tctgagagtc tgctgttact tgtggcaagt cagaacaaaa   4440

ttattgccga cagtgtcacc tcccaggtcc acaatatcta ttcattggtc gagaatggtt   4500

cttacattgt agctgttgat tttgattcaa ttagtggtcg tatcttttgg tctgatgcaa   4560

ctcagggtaa aacctggagt gcgtttcaaa atggaacgga cagaagagtg gtatttgaca   4620

gtagcatcat cttgactgaa actattgcaa tagattgggt aggtcgtaat ctttactgga   4680

cagactatgc tctggaaaca attgaagtct ccaaaattga tgggagccac aggactgtgc   4740

tgattagtaa aaacctaaca aatccaagag gactagcatt agatcccaga atgaatgagc   4800

atctactgtt ctggtctgac tggggccacc accctcgcat cgagcgagcc agcatggacg   4860

gcagcatgcg cactgtcatt gtccaggaca agatcttctg gccctgcggc ttaactattg   4920

actaccccaa cagactgctc tacttcatgg actcctatct tgattacatg gacttttgcg   4980

attataatgg acaccatcgg agacaggtga tagccagtga tttgattata cggcacccct   5040

atgccctaac tctctttgaa gactctgtgt actggactga ccgtgctact cgtcgggtta   5100

tgcgagccaa caagtggcat ggagggaacc agtcagttgt aatgtataat attcaatggc   5160

cccttgggat tgttgcggtt catccttcga aacaaccaaa ttccgtgaat ccatgtgcct   5220

tttcccgctg cagccatctc tgcctgcttt cctcacaggg gcctcatttt tactcctgtg   5280

tttgtccttc aggatggagt ctgtctcctg atctcctgaa ttgcttgaga gatgatcaac   5340

ctttcttaat aactgtaagg caacatataa tttttggaat ctcccttaat cctgaggtga   5400

agagcaatga tgctatggtc cccatagcag ggatacagaa tggtttagat gttgaatttg   5460

atgatgctga gcaatacatc tattgggttg aaaatccagg tgaaattcac agagtgaaga   5520

cagatggcac caacaggaca gtatttgctt ctatatctat ggtggggcct tctatgaacc   5580

tggccttaga ttggatttca agaaaccttt attctaccaa tcctagaact cagtcaatcg   5640

aggttttgac actccacgga gatatcagat acagaaaaac attgattgcc aatgatggga   5700

cagctcttgg agttggcttt ccaattggca taactgttga tcctgctcgt gggaagctgt   5760

actggtcaga ccaaggaact gacagtgggg ttcctgccaa gatcgccagt gctaacatgg   5820

atggcacatc tgtgaaaact ctctttactg ggaacctcga acacctggag tgtgtcactc   5880

ttgacatcga agagcagaaa ctctactggg cagtcactgg aagaggagtg attgaaagag   5940

gaaacgtgga tggaacagat cggatgatcc tggtacacca gctttcccac ccctggggaa   6000

ttgcagtcca tgattctttc ctttattata ctgatgaaca gtatgaggtc attgaaagag   6060

ttgataaggc cactggggcc aacaaaatag tcttgagaga taatgttcca aatctgaggg   6120

gtcttcaagt ttatcacaga cgcaatgccg ccgaatcctc aaatggctgt agcaacaaca   6180

tgaatgcctg tcagcagatt tgcctgcctg taccaggagg attgttttcc tgcgcctgtg   6240

ccactggatt taaactcaat cctgataatc ggtcctgctc tccatataac tctttcattg   6300

ttgtttcaat gctgtctgca atcagaggct ttagcttgga attgtcagat cattcagaaa   6360

ccatggtgcc ggtggcaggc caaggacgaa acgcactgca tgtggatgtg gatgtgtcct   6420

ctggctttat ttattggtgt gattttagca gctcagtggc atctgataat gcgatccgta   6480

gaattaaacc agatggatct tctctgatga acattgtgac acatggaata ggagaaaatg   6540

gagtccgggg tattgcagtg gattgggtag caggaaatct ttatttcacc aatgcctttg   6600

tttctgaaac actgatagaa gttctgcgga tcaatactac ttaccgccgt gttcttctta   6660

aagtcacagt ggacatgcct aggcatattg ttgtagatcc caagaacaga tacctcttct   6720

gggctgacta tgggcagaga ccaaagattg agcgttcttt ccttgactgt accaatcgaa   6780

cagtgcttgt gtcagagggc attgtcacac cacggggctt ggcagtggac cgaagtgatg   6840

gctacgttta ttgggttgat gattctttag atataattgc aaggattcgt atcaatggag   6900

agaactctga agtgattcgt tatggcagtc gttacccaac tccttatggc atcactgttt   6960

ttgaaaattc tatcatatgg gtagatagga atttgaaaaa gatcttccaa gccagcaagg   7020

aaccagagaa cacagagcca cccacagtga taagagacaa tatcaactgg ctaagagatg   7080

tgaccatctt tgacaagcaa gtccagcccc ggtcaccagc agaggtcaac aacaaccctt   7140

gcttggaaaa caatggtggg tgctctcatc tctgctttgc tctgcctgga ttgcacaccc   7200

caaaatgtga ctgtgccttt gggaccctgc aaagtgatgg caagaattgt gccatttcaa   7260

cagaaaattt cctcatcttt gccttgtcta attccttgag aagcttacac ttggaccctg   7320

aaaaccatag cccacctttc caaacaataa atgtggaaag aactgtcatg tctctagact   7380

atgacagtgt aagtgataga atctacttca cacaaaattt agcctctgga gttggacaga   7440

tttcctatgc caccctgtct tcagggatcc atactccaac tgtcattgct tcaggtatag   7500

ggactgctga tggcattgcc tttgactgga ttactagaag aatttattac agtgactacc   7560

tcaaccagat gattaattcc atggctgaag atgggtctaa ccgcactgtg atagcccgcg   7620

ttccaaaacc aagagcaatt gtgttagatc cctgccaagg gtacctgtac tgggctgact   7680

gggatacaca tgccaaaatc gagagagcca cattgggagg aaacttccgg gtacccattg   7740

tgaacagcag tctggtcatg cccagtgggc tgactctgga ctatgaagag gaccttctct   7800

actgggtgga tgctagtctg cagaggattg aacgcagcac tctgacgggc gtggatcgtg   7860

aagtcattgt caatgcagcc gttcatgctt ttggcttgac tctctatggc cagtatattt   7920

actggactga cttgtacaca caaagaattt accgagctaa caaatatgac gggtcaggtc   7980

agattgcaat gaccacaaat ttgctctccc agcccagggg aatcaacact gttgtgaaga   8040

accagaaaca acagtgtaac aatccttgtg aacagtttaa tgggggctgc agccatatct   8100

gtgcaccagg tccaaatggt gccgagtgcc agtgtccaca tgagggcaac tggtatttgg   8160

ccaacaacag gaagcactgc attgtggaca at                                 8192


<210>  674
<211>  4655
<212>  PRT
<213>  Homosapiens

<400>  674

Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His 
            20                  25                  30          


Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp 
        35                  40                  45              


Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val 
    50                  55                  60                  


Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys 
65                  70                  75                  80  


Ile Pro Ser Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly 
                85                  90                  95      


Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln 
            100                 105                 110         


Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp 
        115                 120                 125             


His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr 
    130                 135                 140                 


Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr 
145                 150                 155                 160 


Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu 
                165                 170                 175     


Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn 
            180                 185                 190         


Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys 
        195                 200                 205             


Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly 
    210                 215                 220                 


Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val 
225                 230                 235                 240 


Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys 
                245                 250                 255     


Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser 
            260                 265                 270         


Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly 
        275                 280                 285             


Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly 
    290                 295                 300                 


Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln 
305                 310                 315                 320 


Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr 
                325                 330                 335     


Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys 
            340                 345                 350         


Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg 
        355                 360                 365             


His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr 
    370                 375                 380                 


Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile 
                405                 410                 415     


Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His 
            420                 425                 430         


Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val 
        435                 440                 445             


Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val 
    450                 455                 460                 


Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys 
465                 470                 475                 480 


Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu 
                485                 490                 495     


Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro 
            500                 505                 510         


Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp 
        515                 520                 525             


Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp 
    530                 535                 540                 


Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala 
545                 550                 555                 560 


Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser 
                565                 570                 575     


Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys 
            580                 585                 590         


Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser 
        595                 600                 605             


Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val 
    610                 615                 620                 


Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln 
625                 630                 635                 640 


Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln 
                645                 650                 655     


Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln 
            660                 665                 670         


Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg 
        675                 680                 685             


Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys 
    690                 695                 700                 


Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg 
705                 710                 715                 720 


Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val 
                725                 730                 735     


Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp 
            740                 745                 750         


Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln 
        755                 760                 765             


Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu 
    770                 775                 780                 


Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp 
785                 790                 795                 800 


Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys 
                805                 810                 815     


Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val 
            820                 825                 830         


Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro 
        835                 840                 845             


Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val 
    850                 855                 860                 


Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala 
865                 870                 875                 880 


Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His 
                885                 890                 895     


Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln 
            900                 905                 910         


Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe 
        915                 920                 925             


Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly 
    930                 935                 940                 


Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu 
945                 950                 955                 960 


Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln 
                965                 970                 975     


Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro 
            980                 985                 990         


Asn Phe Gln Arg Val Cys Gly Cys  Pro Tyr Gly Met Arg  Leu Ala Ser 
        995                 1000                 1005             


Asn His  Leu Thr Cys Glu Gly  Asp Pro Thr Asn Glu  Pro Pro Thr 
    1010                 1015                 1020             


Glu Gln  Cys Gly Leu Phe Ser  Phe Pro Cys Lys Asn  Gly Arg Cys 
    1025                 1030                 1035             


Val Pro  Asn Tyr Tyr Leu Cys  Asp Gly Val Asp Asp  Cys His Asp 
    1040                 1045                 1050             


Asn Ser  Asp Glu Gln Leu Cys  Gly Thr Leu Asn Asn  Thr Cys Ser 
    1055                 1060                 1065             


Ser Ser  Ala Phe Thr Cys Gly  His Gly Glu Cys Ile  Pro Ala His 
    1070                 1075                 1080             


Trp Arg  Cys Asp Lys Arg Asn  Asp Cys Val Asp Gly  Ser Asp Glu 
    1085                 1090                 1095             


His Asn  Cys Pro Thr His Ala  Pro Ala Ser Cys Leu  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Thr  Cys Asp Asn His Gln  Cys Ile Ser Lys Asn  Trp Val Cys 
    1115                 1120                 1125             


Asp Thr  Asp Asn Asp Cys Gly  Asp Gly Ser Asp Glu  Lys Asn Cys 
    1130                 1135                 1140             


Asn Ser  Thr Glu Thr Cys Gln  Pro Ser Gln Phe Asn  Cys Pro Asn 
    1145                 1150                 1155             


His Arg  Cys Ile Asp Leu Ser  Phe Val Cys Asp Gly  Asp Lys Asp 
    1160                 1165                 1170             


Cys Val  Asp Gly Ser Asp Glu  Val Gly Cys Val Leu  Asn Cys Thr 
    1175                 1180                 1185             


Ala Ser  Gln Phe Lys Cys Ala  Ser Gly Asp Lys Cys  Ile Gly Val 
    1190                 1195                 1200             


Thr Asn  Arg Cys Asp Gly Val  Phe Asp Cys Ser Asp  Asn Ser Asp 
    1205                 1210                 1215             


Glu Ala  Gly Cys Pro Thr Arg  Pro Pro Gly Met Cys  His Ser Asp 
    1220                 1225                 1230             


Glu Phe  Gln Cys Gln Glu Asp  Gly Ile Cys Ile Pro  Asn Phe Trp 
    1235                 1240                 1245             


Glu Cys  Asp Gly His Pro Asp  Cys Leu Tyr Gly Ser  Asp Glu His 
    1250                 1255                 1260             


Asn Ala  Cys Val Pro Lys Thr  Cys Pro Ser Ser Tyr  Phe His Cys 
    1265                 1270                 1275             


Asp Asn  Gly Asn Cys Ile His  Arg Ala Trp Leu Cys  Asp Arg Asp 
    1280                 1285                 1290             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Lys Asp Cys  Pro Thr Gln 
    1295                 1300                 1305             


Pro Phe  Arg Cys Pro Ser Trp  Gln Trp Gln Cys Leu  Gly His Asn 
    1310                 1315                 1320             


Ile Cys  Val Asn Leu Ser Val  Val Cys Asp Gly Ile  Phe Asp Cys 
    1325                 1330                 1335             


Pro Asn  Gly Thr Asp Glu Ser  Pro Leu Cys Asn Gly  Asn Ser Cys 
    1340                 1345                 1350             


Ser Asp  Phe Asn Gly Gly Cys  Thr His Glu Cys Val  Gln Glu Pro 
    1355                 1360                 1365             


Phe Gly  Ala Lys Cys Leu Cys  Pro Leu Gly Phe Leu  Leu Ala Asn 
    1370                 1375                 1380             


Asp Ser  Lys Thr Cys Glu Asp  Ile Asp Glu Cys Asp  Ile Leu Gly 
    1385                 1390                 1395             


Ser Cys  Ser Gln His Cys Tyr  Asn Met Arg Gly Ser  Phe Arg Cys 
    1400                 1405                 1410             


Ser Cys  Asp Thr Gly Tyr Met  Leu Glu Ser Asp Gly  Arg Thr Cys 
    1415                 1420                 1425             


Lys Val  Thr Ala Ser Glu Ser  Leu Leu Leu Leu Val  Ala Ser Gln 
    1430                 1435                 1440             


Asn Lys  Ile Ile Ala Asp Ser  Val Thr Ser Gln Val  His Asn Ile 
    1445                 1450                 1455             


Tyr Ser  Leu Val Glu Asn Gly  Ser Tyr Ile Val Ala  Val Asp Phe 
    1460                 1465                 1470             


Asp Ser  Ile Ser Gly Arg Ile  Phe Trp Ser Asp Ala  Thr Gln Gly 
    1475                 1480                 1485             


Lys Thr  Trp Ser Ala Phe Gln  Asn Gly Thr Asp Arg  Arg Val Val 
    1490                 1495                 1500             


Phe Asp  Ser Ser Ile Ile Leu  Thr Glu Thr Ile Ala  Ile Asp Trp 
    1505                 1510                 1515             


Val Gly  Arg Asn Leu Tyr Trp  Thr Asp Tyr Ala Leu  Glu Thr Ile 
    1520                 1525                 1530             


Glu Val  Ser Lys Ile Asp Gly  Ser His Arg Thr Val  Leu Ile Ser 
    1535                 1540                 1545             


Lys Asn  Leu Thr Asn Pro Arg  Gly Leu Ala Leu Asp  Pro Arg Met 
    1550                 1555                 1560             


Asn Glu  His Leu Leu Phe Trp  Ser Asp Trp Gly His  His Pro Arg 
    1565                 1570                 1575             


Ile Glu  Arg Ala Ser Met Asp  Gly Ser Met Arg Thr  Val Ile Val 
    1580                 1585                 1590             


Gln Asp  Lys Ile Phe Trp Pro  Cys Gly Leu Thr Ile  Asp Tyr Pro 
    1595                 1600                 1605             


Asn Arg  Leu Leu Tyr Phe Met  Asp Ser Tyr Leu Asp  Tyr Met Asp 
    1610                 1615                 1620             


Phe Cys  Asp Tyr Asn Gly His  His Arg Arg Gln Val  Ile Ala Ser 
    1625                 1630                 1635             


Asp Leu  Ile Ile Arg His Pro  Tyr Ala Leu Thr Leu  Phe Glu Asp 
    1640                 1645                 1650             


Ser Val  Tyr Trp Thr Asp Arg  Ala Thr Arg Arg Val  Met Arg Ala 
    1655                 1660                 1665             


Asn Lys  Trp His Gly Gly Asn  Gln Ser Val Val Met  Tyr Asn Ile 
    1670                 1675                 1680             


Gln Trp  Pro Leu Gly Ile Val  Ala Val His Pro Ser  Lys Gln Pro 
    1685                 1690                 1695             


Asn Ser  Val Asn Pro Cys Ala  Phe Ser Arg Cys Ser  His Leu Cys 
    1700                 1705                 1710             


Leu Leu  Ser Ser Gln Gly Pro  His Phe Tyr Ser Cys  Val Cys Pro 
    1715                 1720                 1725             


Ser Gly  Trp Ser Leu Ser Pro  Asp Leu Leu Asn Cys  Leu Arg Asp 
    1730                 1735                 1740             


Asp Gln  Pro Phe Leu Ile Thr  Val Arg Gln His Ile  Ile Phe Gly 
    1745                 1750                 1755             


Ile Ser  Leu Asn Pro Glu Val  Lys Ser Asn Asp Ala  Met Val Pro 
    1760                 1765                 1770             


Ile Ala  Gly Ile Gln Asn Gly  Leu Asp Val Glu Phe  Asp Asp Ala 
    1775                 1780                 1785             


Glu Gln  Tyr Ile Tyr Trp Val  Glu Asn Pro Gly Glu  Ile His Arg 
    1790                 1795                 1800             


Val Lys  Thr Asp Gly Thr Asn  Arg Thr Val Phe Ala  Ser Ile Ser 
    1805                 1810                 1815             


Met Val  Gly Pro Ser Met Asn  Leu Ala Leu Asp Trp  Ile Ser Arg 
    1820                 1825                 1830             


Asn Leu  Tyr Ser Thr Asn Pro  Arg Thr Gln Ser Ile  Glu Val Leu 
    1835                 1840                 1845             


Thr Leu  His Gly Asp Ile Arg  Tyr Arg Lys Thr Leu  Ile Ala Asn 
    1850                 1855                 1860             


Asp Gly  Thr Ala Leu Gly Val  Gly Phe Pro Ile Gly  Ile Thr Val 
    1865                 1870                 1875             


Asp Pro  Ala Arg Gly Lys Leu  Tyr Trp Ser Asp Gln  Gly Thr Asp 
    1880                 1885                 1890             


Ser Gly  Val Pro Ala Lys Ile  Ala Ser Ala Asn Met  Asp Gly Thr 
    1895                 1900                 1905             


Ser Val  Lys Thr Leu Phe Thr  Gly Asn Leu Glu His  Leu Glu Cys 
    1910                 1915                 1920             


Val Thr  Leu Asp Ile Glu Glu  Gln Lys Leu Tyr Trp  Ala Val Thr 
    1925                 1930                 1935             


Gly Arg  Gly Val Ile Glu Arg  Gly Asn Val Asp Gly  Thr Asp Arg 
    1940                 1945                 1950             


Met Ile  Leu Val His Gln Leu  Ser His Pro Trp Gly  Ile Ala Val 
    1955                 1960                 1965             


His Asp  Ser Phe Leu Tyr Tyr  Thr Asp Glu Gln Tyr  Glu Val Ile 
    1970                 1975                 1980             


Glu Arg  Val Asp Lys Ala Thr  Gly Ala Asn Lys Ile  Val Leu Arg 
    1985                 1990                 1995             


Asp Asn  Val Pro Asn Leu Arg  Gly Leu Gln Val Tyr  His Arg Arg 
    2000                 2005                 2010             


Asn Ala  Ala Glu Ser Ser Asn  Gly Cys Ser Asn Asn  Met Asn Ala 
    2015                 2020                 2025             


Cys Gln  Gln Ile Cys Leu Pro  Val Pro Gly Gly Leu  Phe Ser Cys 
    2030                 2035                 2040             


Ala Cys  Ala Thr Gly Phe Lys  Leu Asn Pro Asp Asn  Arg Ser Cys 
    2045                 2050                 2055             


Ser Pro  Tyr Asn Ser Phe Ile  Val Val Ser Met Leu  Ser Ala Ile 
    2060                 2065                 2070             


Arg Gly  Phe Ser Leu Glu Leu  Ser Asp His Ser Glu  Thr Met Val 
    2075                 2080                 2085             


Pro Val  Ala Gly Gln Gly Arg  Asn Ala Leu His Val  Asp Val Asp 
    2090                 2095                 2100             


Val Ser  Ser Gly Phe Ile Tyr  Trp Cys Asp Phe Ser  Ser Ser Val 
    2105                 2110                 2115             


Ala Ser  Asp Asn Ala Ile Arg  Arg Ile Lys Pro Asp  Gly Ser Ser 
    2120                 2125                 2130             


Leu Met  Asn Ile Val Thr His  Gly Ile Gly Glu Asn  Gly Val Arg 
    2135                 2140                 2145             


Gly Ile  Ala Val Asp Trp Val  Ala Gly Asn Leu Tyr  Phe Thr Asn 
    2150                 2155                 2160             


Ala Phe  Val Ser Glu Thr Leu  Ile Glu Val Leu Arg  Ile Asn Thr 
    2165                 2170                 2175             


Thr Tyr  Arg Arg Val Leu Leu  Lys Val Thr Val Asp  Met Pro Arg 
    2180                 2185                 2190             


His Ile  Val Val Asp Pro Lys  Asn Arg Tyr Leu Phe  Trp Ala Asp 
    2195                 2200                 2205             


Tyr Gly  Gln Arg Pro Lys Ile  Glu Arg Ser Phe Leu  Asp Cys Thr 
    2210                 2215                 2220             


Asn Arg  Thr Val Leu Val Ser  Glu Gly Ile Val Thr  Pro Arg Gly 
    2225                 2230                 2235             


Leu Ala  Val Asp Arg Ser Asp  Gly Tyr Val Tyr Trp  Val Asp Asp 
    2240                 2245                 2250             


Ser Leu  Asp Ile Ile Ala Arg  Ile Arg Ile Asn Gly  Glu Asn Ser 
    2255                 2260                 2265             


Glu Val  Ile Arg Tyr Gly Ser  Arg Tyr Pro Thr Pro  Tyr Gly Ile 
    2270                 2275                 2280             


Thr Val  Phe Glu Asn Ser Ile  Ile Trp Val Asp Arg  Asn Leu Lys 
    2285                 2290                 2295             


Lys Ile  Phe Gln Ala Ser Lys  Glu Pro Glu Asn Thr  Glu Pro Pro 
    2300                 2305                 2310             


Thr Val  Ile Arg Asp Asn Ile  Asn Trp Leu Arg Asp  Val Thr Ile 
    2315                 2320                 2325             


Phe Asp  Lys Gln Val Gln Pro  Arg Ser Pro Ala Glu  Val Asn Asn 
    2330                 2335                 2340             


Asn Pro  Cys Leu Glu Asn Asn  Gly Gly Cys Ser His  Leu Cys Phe 
    2345                 2350                 2355             


Ala Leu  Pro Gly Leu His Thr  Pro Lys Cys Asp Cys  Ala Phe Gly 
    2360                 2365                 2370             


Thr Leu  Gln Ser Asp Gly Lys  Asn Cys Ala Ile Ser  Thr Glu Asn 
    2375                 2380                 2385             


Phe Leu  Ile Phe Ala Leu Ser  Asn Ser Leu Arg Ser  Leu His Leu 
    2390                 2395                 2400             


Asp Pro  Glu Asn His Ser Pro  Pro Phe Gln Thr Ile  Asn Val Glu 
    2405                 2410                 2415             


Arg Thr  Val Met Ser Leu Asp  Tyr Asp Ser Val Ser  Asp Arg Ile 
    2420                 2425                 2430             


Tyr Phe  Thr Gln Asn Leu Ala  Ser Gly Val Gly Gln  Ile Ser Tyr 
    2435                 2440                 2445             


Ala Thr  Leu Ser Ser Gly Ile  His Thr Pro Thr Val  Ile Ala Ser 
    2450                 2455                 2460             


Gly Ile  Gly Thr Ala Asp Gly  Ile Ala Phe Asp Trp  Ile Thr Arg 
    2465                 2470                 2475             


Arg Ile  Tyr Tyr Ser Asp Tyr  Leu Asn Gln Met Ile  Asn Ser Met 
    2480                 2485                 2490             


Ala Glu  Asp Gly Ser Asn Arg  Thr Val Ile Ala Arg  Val Pro Lys 
    2495                 2500                 2505             


Pro Arg  Ala Ile Val Leu Asp  Pro Cys Gln Gly Tyr  Leu Tyr Trp 
    2510                 2515                 2520             


Ala Asp  Trp Asp Thr His Ala  Lys Ile Glu Arg Ala  Thr Leu Gly 
    2525                 2530                 2535             


Gly Asn  Phe Arg Val Pro Ile  Val Asn Ser Ser Leu  Val Met Pro 
    2540                 2545                 2550             


Ser Gly  Leu Thr Leu Asp Tyr  Glu Glu Asp Leu Leu  Tyr Trp Val 
    2555                 2560                 2565             


Asp Ala  Ser Leu Gln Arg Ile  Glu Arg Ser Thr Leu  Thr Gly Val 
    2570                 2575                 2580             


Asp Arg  Glu Val Ile Val Asn  Ala Ala Val His Ala  Phe Gly Leu 
    2585                 2590                 2595             


Thr Leu  Tyr Gly Gln Tyr Ile  Tyr Trp Thr Asp Leu  Tyr Thr Gln 
    2600                 2605                 2610             


Arg Ile  Tyr Arg Ala Asn Lys  Tyr Asp Gly Ser Gly  Gln Ile Ala 
    2615                 2620                 2625             


Met Thr  Thr Asn Leu Leu Ser  Gln Pro Arg Gly Ile  Asn Thr Val 
    2630                 2635                 2640             


Val Lys  Asn Gln Lys Gln Gln  Cys Asn Asn Pro Cys  Glu Gln Phe 
    2645                 2650                 2655             


Asn Gly  Gly Cys Ser His Ile  Cys Ala Pro Gly Pro  Asn Gly Ala 
    2660                 2665                 2670             


Glu Cys  Gln Cys Pro His Glu  Gly Asn Trp Tyr Leu  Ala Asn Asn 
    2675                 2680                 2685             


Arg Lys  His Cys Ile Val Asp  Asn Gly Glu Arg Cys  Gly Ala Ser 
    2690                 2695                 2700             


Ser Phe  Thr Cys Ser Asn Gly  Arg Cys Ile Ser Glu  Glu Trp Lys 
    2705                 2710                 2715             


Cys Asp  Asn Asp Asn Asp Cys  Gly Asp Gly Ser Asp  Glu Met Glu 
    2720                 2725                 2730             


Ser Val  Cys Ala Leu His Thr  Cys Ser Pro Thr Ala  Phe Thr Cys 
    2735                 2740                 2745             


Ala Asn  Gly Arg Cys Val Gln  Tyr Ser Tyr Arg Cys  Asp Tyr Tyr 
    2750                 2755                 2760             


Asn Asp  Cys Gly Asp Gly Ser  Asp Glu Ala Gly Cys  Leu Phe Arg 
    2765                 2770                 2775             


Asp Cys  Asn Ala Thr Thr Glu  Phe Met Cys Asn Asn  Arg Arg Cys 
    2780                 2785                 2790             


Ile Pro  Arg Glu Phe Ile Cys  Asn Gly Val Asp Asn  Cys His Asp 
    2795                 2800                 2805             


Asn Asn  Thr Ser Asp Glu Lys  Asn Cys Pro Asp Arg  Thr Cys Gln 
    2810                 2815                 2820             


Ser Gly  Tyr Thr Lys Cys His  Asn Ser Asn Ile Cys  Ile Pro Arg 
    2825                 2830                 2835             


Val Tyr  Leu Cys Asp Gly Asp  Asn Asp Cys Gly Asp  Asn Ser Asp 
    2840                 2845                 2850             


Glu Asn  Pro Thr Tyr Cys Thr  Thr His Thr Cys Ser  Ser Ser Glu 
    2855                 2860                 2865             


Phe Gln  Cys Ala Ser Gly Arg  Cys Ile Pro Gln His  Trp Tyr Cys 
    2870                 2875                 2880             


Asp Gln  Glu Thr Asp Cys Phe  Asp Ala Ser Asp Glu  Pro Ala Ser 
    2885                 2890                 2895             


Cys Gly  His Ser Glu Arg Thr  Cys Leu Ala Asp Glu  Phe Lys Cys 
    2900                 2905                 2910             


Asp Gly  Gly Arg Cys Ile Pro  Ser Glu Trp Ile Cys  Asp Gly Asp 
    2915                 2920                 2925             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Asp Lys Arg  His Gln Cys 
    2930                 2935                 2940             


Gln Asn  Gln Asn Cys Ser Asp  Ser Glu Phe Leu Cys  Val Asn Asp 
    2945                 2950                 2955             


Arg Pro  Pro Asp Arg Arg Cys  Ile Pro Gln Ser Trp  Val Cys Asp 
    2960                 2965                 2970             


Gly Asp  Val Asp Cys Thr Asp  Gly Tyr Asp Glu Asn  Gln Asn Cys 
    2975                 2980                 2985             


Thr Arg  Arg Thr Cys Ser Glu  Asn Glu Phe Thr Cys  Gly Tyr Gly 
    2990                 2995                 3000             


Leu Cys  Ile Pro Lys Ile Phe  Arg Cys Asp Arg His  Asn Asp Cys 
    3005                 3010                 3015             


Gly Asp  Tyr Ser Asp Glu Arg  Gly Cys Leu Tyr Gln  Thr Cys Gln 
    3020                 3025                 3030             


Gln Asn  Gln Phe Thr Cys Gln  Asn Gly Arg Cys Ile  Ser Lys Thr 
    3035                 3040                 3045             


Phe Val  Cys Asp Glu Asp Asn  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3050                 3055                 3060             


Leu Met  His Leu Cys His Thr  Pro Glu Pro Thr Cys  Pro Pro His 
    3065                 3070                 3075             


Glu Phe  Lys Cys Asp Asn Gly  Arg Cys Ile Glu Met  Met Lys Leu 
    3080                 3085                 3090             


Cys Asn  His Leu Asp Asp Cys  Leu Asp Asn Ser Asp  Glu Lys Gly 
    3095                 3100                 3105             


Cys Gly  Ile Asn Glu Cys His  Asp Pro Ser Ile Ser  Gly Cys Asp 
    3110                 3115                 3120             


His Asn  Cys Thr Asp Thr Leu  Thr Ser Phe Tyr Cys  Ser Cys Arg 
    3125                 3130                 3135             


Pro Gly  Tyr Lys Leu Met Ser  Asp Lys Arg Thr Cys  Val Asp Ile 
    3140                 3145                 3150             


Asp Glu  Cys Thr Glu Met Pro  Phe Val Cys Ser Gln  Lys Cys Glu 
    3155                 3160                 3165             


Asn Val  Ile Gly Ser Tyr Ile  Cys Lys Cys Ala Pro  Gly Tyr Leu 
    3170                 3175                 3180             


Arg Glu  Pro Asp Gly Lys Thr  Cys Arg Gln Asn Ser  Asn Ile Glu 
    3185                 3190                 3195             


Pro Tyr  Leu Ile Phe Ser Asn  Arg Tyr Tyr Leu Arg  Asn Leu Thr 
    3200                 3205                 3210             


Ile Asp  Gly Tyr Phe Tyr Ser  Leu Ile Leu Glu Gly  Leu Asp Asn 
    3215                 3220                 3225             


Val Val  Ala Leu Asp Phe Asp  Arg Val Glu Lys Arg  Leu Tyr Trp 
    3230                 3235                 3240             


Ile Asp  Thr Gln Arg Gln Val  Ile Glu Arg Met Phe  Leu Asn Lys 
    3245                 3250                 3255             


Thr Asn  Lys Glu Thr Ile Ile  Asn His Arg Leu Pro  Ala Ala Glu 
    3260                 3265                 3270             


Ser Leu  Ala Val Asp Trp Val  Ser Arg Lys Leu Tyr  Trp Leu Asp 
    3275                 3280                 3285             


Ala Arg  Leu Asp Gly Leu Phe  Val Ser Asp Leu Asn  Gly Gly His 
    3290                 3295                 3300             


Arg Arg  Met Leu Ala Gln His  Cys Val Asp Ala Asn  Asn Thr Phe 
    3305                 3310                 3315             


Cys Phe  Asp Asn Pro Arg Gly  Leu Ala Leu His Pro  Gln Tyr Gly 
    3320                 3325                 3330             


Tyr Leu  Tyr Trp Ala Asp Trp  Gly His Arg Ala Tyr  Ile Gly Arg 
    3335                 3340                 3345             


Val Gly  Met Asp Gly Thr Asn  Lys Ser Val Ile Ile  Ser Thr Lys 
    3350                 3355                 3360             


Leu Glu  Trp Pro Asn Gly Ile  Thr Ile Asp Tyr Thr  Asn Asp Leu 
    3365                 3370                 3375             


Leu Tyr  Trp Ala Asp Ala His  Leu Gly Tyr Ile Glu  Tyr Ser Asp 
    3380                 3385                 3390             


Leu Glu  Gly His His Arg His  Thr Val Tyr Asp Gly  Ala Leu Pro 
    3395                 3400                 3405             


His Pro  Phe Ala Ile Thr Ile  Phe Glu Asp Thr Ile  Tyr Trp Thr 
    3410                 3415                 3420             


Asp Trp  Asn Thr Arg Thr Val  Glu Lys Gly Asn Lys  Tyr Asp Gly 
    3425                 3430                 3435             


Ser Asn  Arg Gln Thr Leu Val  Asn Thr Thr His Arg  Pro Phe Asp 
    3440                 3445                 3450             


Ile His  Val Tyr His Pro Tyr  Arg Gln Pro Ile Val  Ser Asn Pro 
    3455                 3460                 3465             


Cys Gly  Thr Asn Asn Gly Gly  Cys Ser His Leu Cys  Leu Ile Lys 
    3470                 3475                 3480             


Pro Gly  Gly Lys Gly Phe Thr  Cys Glu Cys Pro Asp  Asp Phe Arg 
    3485                 3490                 3495             


Thr Leu  Gln Leu Ser Gly Ser  Thr Tyr Cys Met Pro  Met Cys Ser 
    3500                 3505                 3510             


Ser Thr  Gln Phe Leu Cys Ala  Asn Asn Glu Lys Cys  Ile Pro Ile 
    3515                 3520                 3525             


Trp Trp  Lys Cys Asp Gly Gln  Lys Asp Cys Ser Asp  Gly Ser Asp 
    3530                 3535                 3540             


Glu Leu  Ala Leu Cys Pro Gln  Arg Phe Cys Arg Leu  Gly Gln Phe 
    3545                 3550                 3555             


Gln Cys  Ser Asp Gly Asn Cys  Thr Ser Pro Gln Thr  Leu Cys Asn 
    3560                 3565                 3570             


Ala His  Gln Asn Cys Pro Asp  Gly Ser Asp Glu Asp  Arg Leu Leu 
    3575                 3580                 3585             


Cys Glu  Asn His His Cys Asp  Ser Asn Glu Trp Gln  Cys Ala Asn 
    3590                 3595                 3600             


Lys Arg  Cys Ile Pro Glu Ser  Trp Gln Cys Asp Thr  Phe Asn Asp 
    3605                 3610                 3615             


Cys Glu  Asp Asn Ser Asp Glu  Asp Ser Ser His Cys  Ala Ser Arg 
    3620                 3625                 3630             


Thr Cys  Arg Pro Gly Gln Phe  Arg Cys Ala Asn Gly  Arg Cys Ile 
    3635                 3640                 3645             


Pro Gln  Ala Trp Lys Cys Asp  Val Asp Asn Asp Cys  Gly Asp His 
    3650                 3655                 3660             


Ser Asp  Glu Pro Ile Glu Glu  Cys Met Ser Ser Ala  His Leu Cys 
    3665                 3670                 3675             


Asp Asn  Phe Thr Glu Phe Ser  Cys Lys Thr Asn Tyr  Arg Cys Ile 
    3680                 3685                 3690             


Pro Lys  Trp Ala Val Cys Asn  Gly Val Asp Asp Cys  Arg Asp Asn 
    3695                 3700                 3705             


Ser Asp  Glu Gln Gly Cys Glu  Glu Arg Thr Cys His  Pro Val Gly 
    3710                 3715                 3720             


Asp Phe  Arg Cys Lys Asn His  His Cys Ile Pro Leu  Arg Trp Gln 
    3725                 3730                 3735             


Cys Asp  Gly Gln Asn Asp Cys  Gly Asp Asn Ser Asp  Glu Glu Asn 
    3740                 3745                 3750             


Cys Ala  Pro Arg Glu Cys Thr  Glu Ser Glu Phe Arg  Cys Val Asn 
    3755                 3760                 3765             


Gln Gln  Cys Ile Pro Ser Arg  Trp Ile Cys Asp His  Tyr Asn Asp 
    3770                 3775                 3780             


Cys Gly  Asp Asn Ser Asp Glu  Arg Asp Cys Glu Met  Arg Thr Cys 
    3785                 3790                 3795             


His Pro  Glu Tyr Phe Gln Cys  Thr Ser Gly His Cys  Val His Ser 
    3800                 3805                 3810             


Glu Leu  Lys Cys Asp Gly Ser  Ala Asp Cys Leu Asp  Ala Ser Asp 
    3815                 3820                 3825             


Glu Ala  Asp Cys Pro Thr Arg  Phe Pro Asp Gly Ala  Tyr Cys Gln 
    3830                 3835                 3840             


Ala Thr  Met Phe Glu Cys Lys  Asn His Val Cys Ile  Pro Pro Tyr 
    3845                 3850                 3855             


Trp Lys  Cys Asp Gly Asp Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3860                 3865                 3870             


Glu Leu  His Leu Cys Leu Asp  Val Pro Cys Asn Ser  Pro Asn Arg 
    3875                 3880                 3885             


Phe Arg  Cys Asp Asn Asn Arg  Cys Ile Tyr Ser His  Glu Val Cys 
    3890                 3895                 3900             


Asn Gly  Val Asp Asp Cys Gly  Asp Gly Thr Asp Glu  Thr Glu Glu 
    3905                 3910                 3915             


His Cys  Arg Lys Pro Thr Pro  Lys Pro Cys Thr Glu  Tyr Glu Tyr 
    3920                 3925                 3930             


Lys Cys  Gly Asn Gly His Cys  Ile Pro His Asp Asn  Val Cys Asp 
    3935                 3940                 3945             


Asp Ala  Asp Asp Cys Gly Asp  Trp Ser Asp Glu Leu  Gly Cys Asn 
    3950                 3955                 3960             


Lys Gly  Lys Glu Arg Thr Cys  Ala Glu Asn Ile Cys  Glu Gln Asn 
    3965                 3970                 3975             


Cys Thr  Gln Leu Asn Glu Gly  Gly Phe Ile Cys Ser  Cys Thr Ala 
    3980                 3985                 3990             


Gly Phe  Glu Thr Asn Val Phe  Asp Arg Thr Ser Cys  Leu Asp Ile 
    3995                 4000                 4005             


Asn Glu  Cys Glu Gln Phe Gly  Thr Cys Pro Gln His  Cys Arg Asn 
    4010                 4015                 4020             


Thr Lys  Gly Ser Tyr Glu Cys  Val Cys Ala Asp Gly  Phe Thr Ser 
    4025                 4030                 4035             


Met Ser  Asp Arg Pro Gly Lys  Arg Cys Ala Ala Glu  Gly Ser Ser 
    4040                 4045                 4050             


Pro Leu  Leu Leu Leu Pro Asp  Asn Val Arg Ile Arg  Lys Tyr Asn 
    4055                 4060                 4065             


Leu Ser  Ser Glu Arg Phe Ser  Glu Tyr Leu Gln Asp  Glu Glu Tyr 
    4070                 4075                 4080             


Ile Gln  Ala Val Asp Tyr Asp  Trp Asp Pro Lys Asp  Ile Gly Leu 
    4085                 4090                 4095             


Ser Val  Val Tyr Tyr Thr Val  Arg Gly Glu Gly Ser  Arg Phe Gly 
    4100                 4105                 4110             


Ala Ile  Lys Arg Ala Tyr Ile  Pro Asn Phe Glu Ser  Gly Arg Asn 
    4115                 4120                 4125             


Asn Leu  Val Gln Glu Val Asp  Leu Lys Leu Lys Tyr  Val Met Gln 
    4130                 4135                 4140             


Pro Asp  Gly Ile Ala Val Asp  Trp Val Gly Arg His  Ile Tyr Trp 
    4145                 4150                 4155             


Ser Asp  Val Lys Asn Lys Arg  Ile Glu Val Ala Lys  Leu Asp Gly 
    4160                 4165                 4170             


Arg Tyr  Arg Lys Trp Leu Ile  Ser Thr Asp Leu Asp  Gln Pro Ala 
    4175                 4180                 4185             


Ala Ile  Ala Val Asn Pro Lys  Leu Gly Leu Met Phe  Trp Thr Asp 
    4190                 4195                 4200             


Trp Gly  Lys Glu Pro Lys Ile  Glu Ser Ala Trp Met  Asn Gly Glu 
    4205                 4210                 4215             


Asp Arg  Asn Ile Leu Val Phe  Glu Asp Leu Gly Trp  Pro Thr Gly 
    4220                 4225                 4230             


Leu Ser  Ile Asp Tyr Leu Asn  Asn Asp Arg Ile Tyr  Trp Ser Asp 
    4235                 4240                 4245             


Phe Lys  Glu Asp Val Ile Glu  Thr Ile Lys Tyr Asp  Gly Thr Asp 
    4250                 4255                 4260             


Arg Arg  Val Ile Ala Lys Glu  Ala Met Asn Pro Tyr  Ser Leu Asp 
    4265                 4270                 4275             


Ile Phe  Glu Asp Gln Leu Tyr  Trp Ile Ser Lys Glu  Lys Gly Glu 
    4280                 4285                 4290             


Val Trp  Lys Gln Asn Lys Phe  Gly Gln Gly Lys Lys  Glu Lys Thr 
    4295                 4300                 4305             


Leu Val  Val Asn Pro Trp Leu  Thr Gln Val Arg Ile  Phe His Gln 
    4310                 4315                 4320             


Leu Arg  Tyr Asn Lys Ser Val  Pro Asn Leu Cys Lys  Gln Ile Cys 
    4325                 4330                 4335             


Ser His  Leu Cys Leu Leu Arg  Pro Gly Gly Tyr Ser  Cys Ala Cys 
    4340                 4345                 4350             


Pro Gln  Gly Ser Ser Phe Ile  Glu Gly Ser Thr Thr  Glu Cys Asp 
    4355                 4360                 4365             


Ala Ala  Ile Glu Leu Pro Ile  Asn Leu Pro Pro Pro  Cys Arg Cys 
    4370                 4375                 4380             


Met His  Gly Gly Asn Cys Tyr  Phe Asp Glu Thr Asp  Leu Pro Lys 
    4385                 4390                 4395             


Cys Lys  Cys Pro Ser Gly Tyr  Thr Gly Lys Tyr Cys  Glu Met Ala 
    4400                 4405                 4410             


Phe Ser  Lys Gly Ile Ser Pro  Gly Thr Thr Ala Val  Ala Val Leu 
    4415                 4420                 4425             


Leu Thr  Ile Leu Leu Ile Val  Val Ile Gly Ala Leu  Ala Ile Ala 
    4430                 4435                 4440             


Gly Phe  Phe His Tyr Arg Arg  Thr Gly Ser Leu Leu  Pro Ala Leu 
    4445                 4450                 4455             


Pro Lys  Leu Pro Ser Leu Ser  Ser Leu Val Lys Pro  Ser Glu Asn 
    4460                 4465                 4470             


Gly Asn  Gly Val Thr Phe Arg  Ser Gly Ala Asp Leu  Asn Met Asp 
    4475                 4480                 4485             


Ile Gly  Val Ser Gly Phe Gly  Pro Glu Thr Ala Ile  Asp Arg Ser 
    4490                 4495                 4500             


Met Ala  Met Ser Glu Asp Phe  Val Met Glu Met Gly  Lys Gln Pro 
    4505                 4510                 4515             


Ile Ile  Phe Glu Asn Pro Met  Tyr Ser Ala Arg Asp  Ser Ala Val 
    4520                 4525                 4530             


Lys Val  Val Gln Pro Ile Gln  Val Thr Val Ser Glu  Asn Val Asp 
    4535                 4540                 4545             


Asn Lys  Asn Tyr Gly Ser Pro  Ile Asn Pro Ser Glu  Ile Val Pro 
    4550                 4555                 4560             


Glu Thr  Asn Pro Thr Ser Pro  Ala Ala Asp Gly Thr  Gln Val Thr 
    4565                 4570                 4575             


Lys Trp  Asn Leu Phe Lys Arg  Lys Ser Lys Gln Thr  Thr Asn Phe 
    4580                 4585                 4590             


Glu Asn  Pro Ile Tyr Ala Gln  Met Glu Asn Glu Gln  Lys Glu Ser 
    4595                 4600                 4605             


Val Ala  Ala Thr Pro Pro Pro  Ser Pro Ser Leu Pro  Ala Lys Pro 
    4610                 4615                 4620             


Lys Pro  Pro Ser Arg Arg Asp  Pro Thr Pro Thr Tyr  Ser Ala Thr 
    4625                 4630                 4635             


Glu Asp  Thr Phe Lys Asp Thr  Ala Asn Leu Val Lys  Glu Asp Ser 
    4640                 4645                 4650             


Glu Val  
    4655 


<210>  675
<211>  5560
<212>  DNA
<213>  Homosapiens

<400>  675
ctagatcgaa agtcctttgg taatgatgtg tcatacattc tagtcatcaa agacaccatt     60

ttctgggcct gaagtgttct gctggttttt ggaggaatga gaatccaatc tctcataagc    120

cggattcaga aaataggtca tcgatgaaac atctgtatgg attatttcac tataatccta    180

tgatgcttgg acttgaatca cttccagatc ccacagacac ctgggaaatt atagagacca    240

ttggtaaagg cacctatggc aaagtctaca aggtaactaa caagagagat gggagcctgg    300

ctgcagtgaa aattctggat ccagtcagtg atatggatga agaaattgag gcagaataca    360

acattttgca gttccttcct aatcatccca atgttgtaaa gttttatggg atgttttaca    420

aagcggatca ctgtgtaggg ggacagctgt ggctggtcct ggagctgtgt aatgggggct    480

cagtcactga gcttgtcaaa ggtctactca gatgtggcca gcggttggat gaagcaatga    540

tctcatacat cttgtacggg gccctcttgg gccttcagca tttgcacaac aaccgaatca    600

tccaccgtga tgtgaagggg aataacattc ttctgacaac agaaggagga gttaagctcg    660

ttgactttgg tgtttcagct caactcacca gtacacgtct gcggagaaac acatctgttg    720

gcaccccatt ctggatggcc cctgaggtca ttgcctgtga gcagcagtat gactcttcct    780

atgacgctcg ctgtgacgtc tggtccttgg ggatcacagc tattgaactg ggggatggag    840

accctcccct ctttgacatg catcctgtga aaacactctt taagattcca agaaatcctc    900

cacctacttt acttcatcca gaaaaatggt gtgaagaatt caaccacttt atttcacagt    960

gtcttattaa ggattttgaa aggcgacctt ccgtcacaca tctccttgac cacccattta   1020

ttaaaggagt acatggaaaa gttctgtttc tgcaaaaaca gctggccaag gttctccaag   1080

accagaagca tcaaaatcct gttgctaaaa ccaggcatga gaggatgcat accagaagac   1140

cttatcatgt ggaagatgct gaaaaatact gccttgagga tgatttggtc aacctagagg   1200

ttctggatga ggatacaatt atccatcagt tgcagaaacg ttatgcagac ttgctaattt   1260

acacatatgt tggagacatc ttaattgcct taaacccctt ccagaatcta agcatatact   1320

ctccacagtt ttccagactt tatcatgggg tgaaacgcgc ctccaatccc ccccacatat   1380

ttgcatcagc agatgctgct taccagtgca tggttactct cagcaaagac cagtgcattg   1440

tcatcagcgg agagagtggc tctgggaaga cagaaagcgc ccacctgatt gttcaacatt   1500

tgactttctt gggaaaggcc aataatcaga ccttgagaga gaaaattcta caagtcaact   1560

ccctggtgga agcctttggg aactcatgca ctgccatcaa tgacaactcg agccgttttg   1620

gaaaatatct ggaaatgatg tttacaccaa ctggagttgt gatgggggca agaatctctg   1680

aatatctcct ggaaaaatcc agagttataa aacaggcagc gagagagaaa aattttcata   1740

tattttacta tatttatgct ggtcttcatc accaaaagaa gctttctgat ttcagacttc   1800

ctgaggaaaa acctcctagg tacatagctg atgaaactgg aagggtgatg cacgacataa   1860

cttccaagga gtcttacaga agacaattcg aagcaattca gcattgcttc aggattatag   1920

ggttcacgga caaagaggtg cactcagtgt acagaatttt ggctgggatt ttgaatattg   1980

ggaacattga gttcgcagct atttcctctc aacatcagac tgataaaagt gaggtgccca   2040

atgctgaagc tttgcaaaat gctgcctctg ttctgtgcat tagccctgaa gagctccagg   2100

aggccctcac ctcccactgt gtggtcaccc ggggcgagac catcatccgt gccaacactg   2160

tagacagggc tgcggacgtt cgagacgcca tgtccaaagc cctgtatggg aggctcttca   2220

gctggattgt gaatcgcatt aatacactcc tgcagccaga cgaaaacata tgtagtgcag   2280

gaggtggaat gaatgtgggg atcttggata tctttggatt cgagaatttt cagagaaatt   2340

catttgagca gctctgcata aacatcgcca atgagcaaat ccagtactat ttcaatcagc   2400

atgtttttgc tcttgagcag atggaatatc agaatgaagg cattgatgct gtacccgtgg   2460

aatatgagga caaccgcccg ctcttggaca tgttcctcca gaaacccctg ggactgcttg   2520

cacttttgga tgaggaaagt cggtttcccc aagcaactga ccagaccctg gttgataaat   2580

ttgaagataa tctacgatgc aaatacttct ggaggcccaa aggagtggaa ctgtgctttg   2640

gcattcagca ttatgctgga aaggtattat atgatgcttc tggggttctt gagaaaaata   2700

gagacactct ccctgccgat gtggttgtgg tcctgagaac gtcagaaaac atgcttcttc   2760

agcagctctt ctcaatccct ctgaccaaaa caggtaattt ggcccagaca agagctagga   2820

taacagtggc ctcaagttct ttgcctccac atttcagtgc tgggaaagcc aaggtggaca   2880

ctctggaggt gatacggcat ccggaagaaa ccaccaacat gaagaggcaa actgtggctt   2940

cttacttccg gtattctctg atggacctgc tctccaaaat ggtggttgga cagccccact   3000

ttgtgcgctg cattaaaccc aatgatgacc gagaggccct gcagttctct cgagagaggg   3060

tgctggccca gctccgctcc acagggattc tggagacagt cagcatccgc cgccagggct   3120

attcccaccg catccttttt gaagaatttg tgaaaaggta ttattacttg gcattcacag   3180

cacatcaaac acctcttgct agcaaagaga gctgtgtggc tatcttggaa aagtccagat   3240

tagatcactg ggtgctggga aaaacaaagg tttttctcaa atattaccat gttgagcaat   3300

taaatttgct gcttcgagaa gtcataggca gagtggttgt gctgcaggca tataccaagg   3360

ggtggcttgg agccaggaga tacaaaaagg tcagagagaa gagagagaag ggagccattg   3420

ccatccagtc agcctggaga ggatatgatg ctcggaggaa atttaagaaa ataagcaaca   3480

gaaggaatga gtctgctgct cataatcaag caggggacac ttcaaaccaa agcagtgggc   3540

cacattcccc cgtcgcagca ggtacgaggg gaagtgccga ggttcaagac tgcagcgagc   3600

ctggtgacca taaagttctc aggggctctg tacatcgtag gagccattca caagcagaat   3660

ccaacaatgg ccgtacacag acttcaagca actctcctgc tgtcacagag aaaaatgggc   3720

attcacaagc ccagagttct ccaaaagggt gcgatatctt cgcaggacat gcaaacaagc   3780

actcggtttc tgggactgat ttgctgtctt ctcggatatg ccatcctgct ccagatcagc   3840

aaggattgag tctctgggga gcccctcaaa agcctgcctt tccacattac ggatgtaact   3900

tttatgggtt cagaaaatgg tcttgcacag aagcatcgaa cacctcgccg acgatgtcag   3960

cagcccaaaa tgctgagtag ccctgaggac accatgtact ataaccagtt aaatggaact   4020

ctagaatatc aagggagcaa gaggaagcca agaaaacttg gccaaatcaa agtacttgat   4080

ggggaagatg aatattacaa atctctgtca ccagtggact gtatccctga ggagaacaac   4140

tcagcccacc cttccttttt ttcttcatcc tcaaaaggag actcttttgc tcaacattaa   4200

attgtgcttc ctaaccctaa atctgtccag agtaggaaca ttcatggtaa tcgactgtct   4260

gtcattgcgt aagaaagcac tgatatgggg tcagcttctt tggacatatg gtccatgcct   4320

gaaccttact gaaccacttg cagattccaa aacatcttat cctatcctct accactctcc   4380

cacatgtgtt gtgcagcctg agctgggcgc tgccttcctt tctcatccca tggggccctg   4440

tgggacactg agaacacctt tacaatagtt taaacagtca ttcatgcccc cagtgtctag   4500

gaagataaca gccagtctca ccccagtcta atcatggacc ctgataatat tgcttgattt   4560

ttcctatcaa gttacttttc aatccattca gaatctgccc cagtggagac ccaggagttc   4620

ctttcctgca ctcttctcca tcctcccacc tttgctgggc ttttctatca ctcccacctc   4680

ccccagagtc agggctccat tgctgagtgc cccatcctgg aggattggcc ccaagatctc   4740

ctagaacagg ataattgcct gtgtttaggc agataggcct aaatctttca gattctttct   4800

acaaggcaaa taacccctct cttgttaatt atgatgctga gaaagcctct gtctctttat   4860

ttcaccttgc caagacaccc acactacttt ggtgatgaaa agaaaggaat gagagggaaa   4920

gtttggacct gtcactttgg tgacagggaa agtccaggtc actttattct gtaactctcc   4980

attcactggt caaataactc catgaggcta tcagtggcta cagtggaagg acctgatctt   5040

gtccatcttt gtgtgcacag agcctagcac agggcttggt agagggtata tctagtgaat   5100

ggagaataca tggagaaact taactaagtt acacaagcat atctgacagg aatgttacct   5160

tcaattgtat gttacatatg attagtcact tttcatacac tataacctct gatttttcac   5220

tcaagtttgg gctgattata ttgtaatgat gttagataat actcaacatg attcagtatg   5280

acaaactttt ttgagcacct actttatata aaacatgaca aattgcagtg tgatgtaatc   5340

aaaaacaaag aagccctata agaccatttc tctagaacag atgttcttaa tatttttctt   5400

actctaaaat atgtggtaga tagtatgcaa gaaaagccgg gtgcggtggc tcaggcctgt   5460

aatcccagca ctttgggagg ccaagatggg cggatcatga agtcaggagt tcgagaccag   5520

cctgaccaac atggtgaaac cccgtctcta ctaaaaaaaa                         5560


<210>  676
<211>  1278
<212>  PRT
<213>  Homosapiens

<400>  676

Met Lys His Leu Tyr Gly Leu Phe His Tyr Asn Pro Met Met Leu Gly 
1               5                   10                  15      


Leu Glu Ser Leu Pro Asp Pro Thr Asp Thr Trp Glu Ile Ile Glu Thr 
            20                  25                  30          


Ile Gly Lys Gly Thr Tyr Gly Lys Val Tyr Lys Val Thr Asn Lys Arg 
        35                  40                  45              


Asp Gly Ser Leu Ala Ala Val Lys Ile Leu Asp Pro Val Ser Asp Met 
    50                  55                  60                  


Asp Glu Glu Ile Glu Ala Glu Tyr Asn Ile Leu Gln Phe Leu Pro Asn 
65                  70                  75                  80  


His Pro Asn Val Val Lys Phe Tyr Gly Met Phe Tyr Lys Ala Asp His 
                85                  90                  95      


Cys Val Gly Gly Gln Leu Trp Leu Val Leu Glu Leu Cys Asn Gly Gly 
            100                 105                 110         


Ser Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys Gly Gln Arg Leu 
        115                 120                 125             


Asp Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala Leu Leu Gly Leu 
    130                 135                 140                 


Gln His Leu His Asn Asn Arg Ile Ile His Arg Asp Val Lys Gly Asn 
145                 150                 155                 160 


Asn Ile Leu Leu Thr Thr Glu Gly Gly Val Lys Leu Val Asp Phe Gly 
                165                 170                 175     


Val Ser Ala Gln Leu Thr Ser Thr Arg Leu Arg Arg Asn Thr Ser Val 
            180                 185                 190         


Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Ala Cys Glu Gln Gln 
        195                 200                 205             


Tyr Asp Ser Ser Tyr Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile 
    210                 215                 220                 


Thr Ala Ile Glu Leu Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His 
225                 230                 235                 240 


Pro Val Lys Thr Leu Phe Lys Ile Pro Arg Asn Pro Pro Pro Thr Leu 
                245                 250                 255     


Leu His Pro Glu Lys Trp Cys Glu Glu Phe Asn His Phe Ile Ser Gln 
            260                 265                 270         


Cys Leu Ile Lys Asp Phe Glu Arg Arg Pro Ser Val Thr His Leu Leu 
        275                 280                 285             


Asp His Pro Phe Ile Lys Gly Val His Gly Lys Val Leu Phe Leu Gln 
    290                 295                 300                 


Lys Gln Leu Ala Lys Val Leu Gln Asp Gln Lys His Gln Asn Pro Val 
305                 310                 315                 320 


Ala Lys Thr Arg His Glu Arg Met His Thr Arg Arg Pro Tyr His Val 
                325                 330                 335     


Glu Asp Ala Glu Lys Tyr Cys Leu Glu Asp Asp Leu Val Asn Leu Glu 
            340                 345                 350         


Val Leu Asp Glu Asp Thr Ile Ile His Gln Leu Gln Lys Arg Tyr Ala 
        355                 360                 365             


Asp Leu Leu Ile Tyr Thr Tyr Val Gly Asp Ile Leu Ile Ala Leu Asn 
    370                 375                 380                 


Pro Phe Gln Asn Leu Ser Ile Tyr Ser Pro Gln Phe Ser Arg Leu Tyr 
385                 390                 395                 400 


His Gly Val Lys Arg Ala Ser Asn Pro Pro His Ile Phe Ala Ser Ala 
                405                 410                 415     


Asp Ala Ala Tyr Gln Cys Met Val Thr Leu Ser Lys Asp Gln Cys Ile 
            420                 425                 430         


Val Ile Ser Gly Glu Ser Gly Ser Gly Lys Thr Glu Ser Ala His Leu 
        435                 440                 445             


Ile Val Gln His Leu Thr Phe Leu Gly Lys Ala Asn Asn Gln Thr Leu 
    450                 455                 460                 


Arg Glu Lys Ile Leu Gln Val Asn Ser Leu Val Glu Ala Phe Gly Asn 
465                 470                 475                 480 


Ser Cys Thr Ala Ile Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Leu 
                485                 490                 495     


Glu Met Met Phe Thr Pro Thr Gly Val Val Met Gly Ala Arg Ile Ser 
            500                 505                 510         


Glu Tyr Leu Leu Glu Lys Ser Arg Val Ile Lys Gln Ala Ala Arg Glu 
        515                 520                 525             


Lys Asn Phe His Ile Phe Tyr Tyr Ile Tyr Ala Gly Leu His His Gln 
    530                 535                 540                 


Lys Lys Leu Ser Asp Phe Arg Leu Pro Glu Glu Lys Pro Pro Arg Tyr 
545                 550                 555                 560 


Ile Ala Asp Glu Thr Gly Arg Val Met His Asp Ile Thr Ser Lys Glu 
                565                 570                 575     


Ser Tyr Arg Arg Gln Phe Glu Ala Ile Gln His Cys Phe Arg Ile Ile 
            580                 585                 590         


Gly Phe Thr Asp Lys Glu Val His Ser Val Tyr Arg Ile Leu Ala Gly 
        595                 600                 605             


Ile Leu Asn Ile Gly Asn Ile Glu Phe Ala Ala Ile Ser Ser Gln His 
    610                 615                 620                 


Gln Thr Asp Lys Ser Glu Val Pro Asn Ala Glu Ala Leu Gln Asn Ala 
625                 630                 635                 640 


Ala Ser Val Leu Cys Ile Ser Pro Glu Glu Leu Gln Glu Ala Leu Thr 
                645                 650                 655     


Ser His Cys Val Val Thr Arg Gly Glu Thr Ile Ile Arg Ala Asn Thr 
            660                 665                 670         


Val Asp Arg Ala Ala Asp Val Arg Asp Ala Met Ser Lys Ala Leu Tyr 
        675                 680                 685             


Gly Arg Leu Phe Ser Trp Ile Val Asn Arg Ile Asn Thr Leu Leu Gln 
    690                 695                 700                 


Pro Asp Glu Asn Ile Cys Ser Ala Gly Gly Gly Met Asn Val Gly Ile 
705                 710                 715                 720 


Leu Asp Ile Phe Gly Phe Glu Asn Phe Gln Arg Asn Ser Phe Glu Gln 
                725                 730                 735     


Leu Cys Ile Asn Ile Ala Asn Glu Gln Ile Gln Tyr Tyr Phe Asn Gln 
            740                 745                 750         


His Val Phe Ala Leu Glu Gln Met Glu Tyr Gln Asn Glu Gly Ile Asp 
        755                 760                 765             


Ala Val Pro Val Glu Tyr Glu Asp Asn Arg Pro Leu Leu Asp Met Phe 
    770                 775                 780                 


Leu Gln Lys Pro Leu Gly Leu Leu Ala Leu Leu Asp Glu Glu Ser Arg 
785                 790                 795                 800 


Phe Pro Gln Ala Thr Asp Gln Thr Leu Val Asp Lys Phe Glu Asp Asn 
                805                 810                 815     


Leu Arg Cys Lys Tyr Phe Trp Arg Pro Lys Gly Val Glu Leu Cys Phe 
            820                 825                 830         


Gly Ile Gln His Tyr Ala Gly Lys Val Leu Tyr Asp Ala Ser Gly Val 
        835                 840                 845             


Leu Glu Lys Asn Arg Asp Thr Leu Pro Ala Asp Val Val Val Val Leu 
    850                 855                 860                 


Arg Thr Ser Glu Asn Met Leu Leu Gln Gln Leu Phe Ser Ile Pro Leu 
865                 870                 875                 880 


Thr Lys Thr Gly Asn Leu Ala Gln Thr Arg Ala Arg Ile Thr Val Ala 
                885                 890                 895     


Ser Ser Ser Leu Pro Pro His Phe Ser Ala Gly Lys Ala Lys Val Asp 
            900                 905                 910         


Thr Leu Glu Val Ile Arg His Pro Glu Glu Thr Thr Asn Met Lys Arg 
        915                 920                 925             


Gln Thr Val Ala Ser Tyr Phe Arg Tyr Ser Leu Met Asp Leu Leu Ser 
    930                 935                 940                 


Lys Met Val Val Gly Gln Pro His Phe Val Arg Cys Ile Lys Pro Asn 
945                 950                 955                 960 


Asp Asp Arg Glu Ala Leu Gln Phe Ser Arg Glu Arg Val Leu Ala Gln 
                965                 970                 975     


Leu Arg Ser Thr Gly Ile Leu Glu Thr Val Ser Ile Arg Arg Gln Gly 
            980                 985                 990         


Tyr Ser His Arg Ile Leu Phe Glu  Glu Phe Val Lys Arg  Tyr Tyr Tyr 
        995                 1000                 1005             


Leu Ala  Phe Thr Ala His Gln  Thr Pro Leu Ala Ser  Lys Glu Ser 
    1010                 1015                 1020             


Cys Val  Ala Ile Leu Glu Lys  Ser Arg Leu Asp His  Trp Val Leu 
    1025                 1030                 1035             


Gly Lys  Thr Lys Val Phe Leu  Lys Tyr Tyr His Val  Glu Gln Leu 
    1040                 1045                 1050             


Asn Leu  Leu Leu Arg Glu Val  Ile Gly Arg Val Val  Val Leu Gln 
    1055                 1060                 1065             


Ala Tyr  Thr Lys Gly Trp Leu  Gly Ala Arg Arg Tyr  Lys Lys Val 
    1070                 1075                 1080             


Arg Glu  Lys Arg Glu Lys Gly  Ala Ile Ala Ile Gln  Ser Ala Trp 
    1085                 1090                 1095             


Arg Gly  Tyr Asp Ala Arg Arg  Lys Phe Lys Lys Ile  Ser Asn Arg 
    1100                 1105                 1110             


Arg Asn  Glu Ser Ala Ala His  Asn Gln Ala Gly Asp  Thr Ser Asn 
    1115                 1120                 1125             


Gln Ser  Ser Gly Pro His Ser  Pro Val Ala Ala Gly  Thr Arg Gly 
    1130                 1135                 1140             


Ser Ala  Glu Val Gln Asp Cys  Ser Glu Pro Gly Asp  His Lys Val 
    1145                 1150                 1155             


Leu Arg  Gly Ser Val His Arg  Arg Ser His Ser Gln  Ala Glu Ser 
    1160                 1165                 1170             


Asn Asn  Gly Arg Thr Gln Thr  Ser Ser Asn Ser Pro  Ala Val Thr 
    1175                 1180                 1185             


Glu Lys  Asn Gly His Ser Gln  Ala Gln Ser Ser Pro  Lys Gly Cys 
    1190                 1195                 1200             


Asp Ile  Phe Ala Gly His Ala  Asn Lys His Ser Val  Ser Gly Thr 
    1205                 1210                 1215             


Asp Leu  Leu Ser Ser Arg Ile  Cys His Pro Ala Pro  Asp Gln Gln 
    1220                 1225                 1230             


Gly Leu  Ser Leu Trp Gly Ala  Pro Gln Lys Pro Ala  Phe Pro His 
    1235                 1240                 1245             


Tyr Gly  Cys Asn Phe Tyr Gly  Phe Arg Lys Trp Ser  Cys Thr Glu 
    1250                 1255                 1260             


Ala Ser  Asn Thr Ser Pro Thr  Met Ser Ala Ala Gln  Asn Ala Glu 
    1265                 1270                 1275             


<210>  677
<211>  4278
<212>  DNA
<213>  Homosapiens

<400>  677
cgggaggagc ggggtccgcg cggcggacga ggcgggggca ggaggcgcag gcagagcgag     60

cgcgggaggt cgccgcagca cagaggacac cgcgcgccgc cgctcaacat ggtcgctgcg    120

cacgctgccc attcttcctc ctctgccgag tggatcgcct gcctggataa aagaccactg    180

gagcgatcca gcgaagatgt ggatataatc ttcactcgac tgaaagaagt taaagctttt    240

gagaaatttc acccaaatct ccttcatcag atttgcttat gtggttatta tgagaatctg    300

gaaaagggaa taacattatt tcgccagggt gatattggaa caaactggta tgctgtcctg    360

gcagggtctt tggatgttaa agtatctgag accagcagtc accaggatgc tgtgaccatc    420

tgtaccctgg gaattgggac ggcctttgga gagtccattc tggacaacac accccgccat    480

gcaaccatcg ttaccaggga gagcagtgaa ctgctccgca tcgagcagaa ggacttcaag    540

gcactatggg agaaatatcg acagtatatg gcaggacttc tggctcctcc ttatggtgtt    600

atggaaacgg gctctaacaa tgacaggatt cctgacaagg agaacacacc tctcattgaa    660

cctcacgttc ctcttcgtcc tgctaacacc attaccaagg tcccttcaga gaagatcctc    720

agagctggaa aaattttacg aaatgccatt ctctctcgag cacctcacat gataagagat    780

agaaaatacc acctaaagac atacagacaa tgctgtgtgg gaactgaact ggtggactgg    840

atgatgcagc agacaccatg tgttcactcc cggactcaag ctgttggcat gtggcaagtc    900

ctgttagaag atggtgttct caaccacgtg gaccaggagc accatttcca agacaaatat    960

ttattctatc gatttctgga tgatgagcac gaggatgccc ctttgcctac tgaggaggag   1020

aagaaggagt gtgatgagga gctccaggac accatgctgc tgctgtcaca gatgggcccc   1080

gacgcccaca tgaggatgat ccttcgcaaa ccacctggcc agaggactgt ggatgaccta   1140

gagattatct atgaggagct tcttcatatt aaagccttat cccatctttc taccacagtg   1200

aaacgagagt tagcaggtgt tctcattttt gagtctcacg ccaaaggagg gactgtgttg   1260

tttaaccagg gggaagaagg tacctcctgg tacattattc taaaaggatc agtgaatgta   1320

gtcatttacg gcaagggtgt ggtctgcacc ctgcatgaag gagatgactt cggcaagtta   1380

gcactagtga atgatgcccc acgagctgcc tctatcgtct tacgagaaga taactgccat   1440

ttcttaagag tagacaagga ggatttcaac cggatcctaa gggacgtgga ggcgaataca   1500

gtcagactta aagaacatga ccaagatgtc ttggtgctgg agaaggtccc agcagggaac   1560

agagcttcta atcaaggaaa ctcacagcct cagcaaaagt atactgtgat gtcaggaaca   1620

cctgaaaaaa ttttagagca ttttctagaa acaatacgcc ttgaggcaac tttaaatgaa   1680

gcaacagatt ctgttttaaa tgactttatt atgatgcact gtgtttttat gccaaatacc   1740

cagctttgcc cggcactggt ggcccactac cacgcacagc cttcacaagg tacagaacag   1800

gagaaaatgg attatgccct caacaataag aggcgagtca tccgcctggt tctacagtgg   1860

gctgccatgt atggagacct cctgcaagag gatgacgtat ctatggcctt cctggaggag   1920

ttttatgtat ctgtatcaga tgatgcccgg atgattgctg ccctcaagga gcaactgcca   1980

gagttggaga agattgtcaa gcaaatctca gaagatgcaa aggcaccaca aaagaagcac   2040

aaggttcttt tgcaacagtt caatacgggc gatgagagag cccagaagcg ccagcctatc   2100

cgcggctctg atgaagttct gtttaaggtc tattgcatgg accacaccta cacaaccatt   2160

cgggtgccag tggccacttc ggtgaaggaa gtcatcagtg cagttgccga caagctgggc   2220

tccggggagg gcctgatcat agtcaagatg agttccggag gagaaaaggt ggtgctcaaa   2280

cctaatgatg tttcagtatt tacgacgctc accattaatg gacgcctgtt tgcttgcccg   2340

cgagagcaat tcgattcact gactccctta ccagaacagg aaggcccaac tgttggaaca   2400

gtgggaactt ttgaactgat gagctccaaa gatttagcat accagatgac aatttatgat   2460

tgggaactct tcaactgcgt gcatgagctg gagctaatct atcacacatt tggaaggcat   2520

aattttaaaa agaccacagc aaacttggat ttgttcctga ggagatttaa tgaaattcag   2580

ttttgggtcg tcactgagat ctgcctttgt tctcagctca gcaagcgtgt tcagctatta   2640

aaaaaattta ttaagatagc agcccactgt aaggagtata aaaatctgaa ttcctttttt   2700

gccatcgtca tgggactaag taacattgct gtgagccgct tggcactaac gtgggagaaa   2760

ctgccaagca agttcaagaa gttctatgcg gagtttgaaa gtttaatgga cccttcaagg   2820

aaccacaggg cctacaggct gacagtagct aagctggaac ctcctctcat ccccttcatg   2880

cctttgctca ttaaagatat gacatttact catgagggga acaagacgtt cattgacaat   2940

ctagtaaact ttgaaaaaat gcgcatgatt gcaaatacgg ccagaacagt gagatactac   3000

aggagccaac ccttcaatcc tgatgcagct caagctaata agaaccatca ggatgtccgg   3060

agttatgtac ggcaattaaa tgtgattgac aaccagagaa ctttatcaca gatgtcacac   3120

agattagagc ctcgtcgacc atagacattt caaatgccca aagcaacagt ttgtctccag   3180

tccacaatct ttcaaaaatg ccatttatgc tactactgac tgtattgcca ctagagaatt   3240

ctacaaaaca agcaaaaaca catcctgaga cacctcaggg ctgcattcag cttaccagct   3300

acctagcaag agaaggaatt atttgacatg cctaaagctt acacactcta gcttaggaat   3360

ccccagtttg tggctaccct gtttcatttc cacttgtgcc atcttctttg ctgaagtgtt   3420

gaataaggcc cacgtgaaga gtttggtaga aatagccttg tcaagagaac tagcaagccc   3480

ctgacatttt tttctaagag tgtttatggg atgagatgtg ctacaaatgg gatagatttg   3540

gataaaattt taactcaaca tcttgatttg gagcctgggg tttcgggaag gtgttgagga   3600

atctatagaa gtccaaatta taggttgtat tcttccatct tcattgtctt acctctgaag   3660

gaatagaacc tgaccacatt attatgaaac attatggctg tttatgtaat ttagggagga   3720

ctggtctgta atttctgaat gtatatagaa taatatttat gtttacaatg taacttttca   3780

aaatttacaa atcaggatta tatacataag aattccacta agaaatgcca agattcttaa   3840

atttgccagc gttaaagtag aaaataacat ttcagaagag cacaatatgc ataaaacatt   3900

tttcaaaatt gaaatatttt cctgggcatt aaaaaccttt actattggct acaaatttat   3960

tgtacctgat gaaaacatat tttctggact taaatgttat tacaaatatc ttaattttca   4020

gtaattgttt tgcactttca aagattgtaa atagttcatt caatcaatgg tatagagtta   4080

tttatttgct acataataga tactgtgcca aataattact ttttatttat tttatttagt   4140

acgtaatttt gaagtacatt ttttcctgtt ttcacaatta gactacattt aatgtgtagg   4200

aattgtatgt atgtatatct tctgtaaata acatctagta tcttcactaa atataattgt   4260

cgaccgggaa aaaaaaaa                                                 4278


<210>  678
<211>  1011
<212>  PRT
<213>  Homosapiens

<400>  678

Met Val Ala Ala His Ala Ala His Ser Ser Ser Ser Ala Glu Trp Ile 
1               5                   10                  15      


Ala Cys Leu Asp Lys Arg Pro Leu Glu Arg Ser Ser Glu Asp Val Asp 
            20                  25                  30          


Ile Ile Phe Thr Arg Leu Lys Glu Val Lys Ala Phe Glu Lys Phe His 
        35                  40                  45              


Pro Asn Leu Leu His Gln Ile Cys Leu Cys Gly Tyr Tyr Glu Asn Leu 
    50                  55                  60                  


Glu Lys Gly Ile Thr Leu Phe Arg Gln Gly Asp Ile Gly Thr Asn Trp 
65                  70                  75                  80  


Tyr Ala Val Leu Ala Gly Ser Leu Asp Val Lys Val Ser Glu Thr Ser 
                85                  90                  95      


Ser His Gln Asp Ala Val Thr Ile Cys Thr Leu Gly Ile Gly Thr Ala 
            100                 105                 110         


Phe Gly Glu Ser Ile Leu Asp Asn Thr Pro Arg His Ala Thr Ile Val 
        115                 120                 125             


Thr Arg Glu Ser Ser Glu Leu Leu Arg Ile Glu Gln Lys Asp Phe Lys 
    130                 135                 140                 


Ala Leu Trp Glu Lys Tyr Arg Gln Tyr Met Ala Gly Leu Leu Ala Pro 
145                 150                 155                 160 


Pro Tyr Gly Val Met Glu Thr Gly Ser Asn Asn Asp Arg Ile Pro Asp 
                165                 170                 175     


Lys Glu Asn Thr Pro Leu Ile Glu Pro His Val Pro Leu Arg Pro Ala 
            180                 185                 190         


Asn Thr Ile Thr Lys Val Pro Ser Glu Lys Ile Leu Arg Ala Gly Lys 
        195                 200                 205             


Ile Leu Arg Asn Ala Ile Leu Ser Arg Ala Pro His Met Ile Arg Asp 
    210                 215                 220                 


Arg Lys Tyr His Leu Lys Thr Tyr Arg Gln Cys Cys Val Gly Thr Glu 
225                 230                 235                 240 


Leu Val Asp Trp Met Met Gln Gln Thr Pro Cys Val His Ser Arg Thr 
                245                 250                 255     


Gln Ala Val Gly Met Trp Gln Val Leu Leu Glu Asp Gly Val Leu Asn 
            260                 265                 270         


His Val Asp Gln Glu His His Phe Gln Asp Lys Tyr Leu Phe Tyr Arg 
        275                 280                 285             


Phe Leu Asp Asp Glu His Glu Asp Ala Pro Leu Pro Thr Glu Glu Glu 
    290                 295                 300                 


Lys Lys Glu Cys Asp Glu Glu Leu Gln Asp Thr Met Leu Leu Leu Ser 
305                 310                 315                 320 


Gln Met Gly Pro Asp Ala His Met Arg Met Ile Leu Arg Lys Pro Pro 
                325                 330                 335     


Gly Gln Arg Thr Val Asp Asp Leu Glu Ile Ile Tyr Glu Glu Leu Leu 
            340                 345                 350         


His Ile Lys Ala Leu Ser His Leu Ser Thr Thr Val Lys Arg Glu Leu 
        355                 360                 365             


Ala Gly Val Leu Ile Phe Glu Ser His Ala Lys Gly Gly Thr Val Leu 
    370                 375                 380                 


Phe Asn Gln Gly Glu Glu Gly Thr Ser Trp Tyr Ile Ile Leu Lys Gly 
385                 390                 395                 400 


Ser Val Asn Val Val Ile Tyr Gly Lys Gly Val Val Cys Thr Leu His 
                405                 410                 415     


Glu Gly Asp Asp Phe Gly Lys Leu Ala Leu Val Asn Asp Ala Pro Arg 
            420                 425                 430         


Ala Ala Ser Ile Val Leu Arg Glu Asp Asn Cys His Phe Leu Arg Val 
        435                 440                 445             


Asp Lys Glu Asp Phe Asn Arg Ile Leu Arg Asp Val Glu Ala Asn Thr 
    450                 455                 460                 


Val Arg Leu Lys Glu His Asp Gln Asp Val Leu Val Leu Glu Lys Val 
465                 470                 475                 480 


Pro Ala Gly Asn Arg Ala Ser Asn Gln Gly Asn Ser Gln Pro Gln Gln 
                485                 490                 495     


Lys Tyr Thr Val Met Ser Gly Thr Pro Glu Lys Ile Leu Glu His Phe 
            500                 505                 510         


Leu Glu Thr Ile Arg Leu Glu Ala Thr Leu Asn Glu Ala Thr Asp Ser 
        515                 520                 525             


Val Leu Asn Asp Phe Ile Met Met His Cys Val Phe Met Pro Asn Thr 
    530                 535                 540                 


Gln Leu Cys Pro Ala Leu Val Ala His Tyr His Ala Gln Pro Ser Gln 
545                 550                 555                 560 


Gly Thr Glu Gln Glu Lys Met Asp Tyr Ala Leu Asn Asn Lys Arg Arg 
                565                 570                 575     


Val Ile Arg Leu Val Leu Gln Trp Ala Ala Met Tyr Gly Asp Leu Leu 
            580                 585                 590         


Gln Glu Asp Asp Val Ser Met Ala Phe Leu Glu Glu Phe Tyr Val Ser 
        595                 600                 605             


Val Ser Asp Asp Ala Arg Met Ile Ala Ala Leu Lys Glu Gln Leu Pro 
    610                 615                 620                 


Glu Leu Glu Lys Ile Val Lys Gln Ile Ser Glu Asp Ala Lys Ala Pro 
625                 630                 635                 640 


Gln Lys Lys His Lys Val Leu Leu Gln Gln Phe Asn Thr Gly Asp Glu 
                645                 650                 655     


Arg Ala Gln Lys Arg Gln Pro Ile Arg Gly Ser Asp Glu Val Leu Phe 
            660                 665                 670         


Lys Val Tyr Cys Met Asp His Thr Tyr Thr Thr Ile Arg Val Pro Val 
        675                 680                 685             


Ala Thr Ser Val Lys Glu Val Ile Ser Ala Val Ala Asp Lys Leu Gly 
    690                 695                 700                 


Ser Gly Glu Gly Leu Ile Ile Val Lys Met Ser Ser Gly Gly Glu Lys 
705                 710                 715                 720 


Val Val Leu Lys Pro Asn Asp Val Ser Val Phe Thr Thr Leu Thr Ile 
                725                 730                 735     


Asn Gly Arg Leu Phe Ala Cys Pro Arg Glu Gln Phe Asp Ser Leu Thr 
            740                 745                 750         


Pro Leu Pro Glu Gln Glu Gly Pro Thr Val Gly Thr Val Gly Thr Phe 
        755                 760                 765             


Glu Leu Met Ser Ser Lys Asp Leu Ala Tyr Gln Met Thr Ile Tyr Asp 
    770                 775                 780                 


Trp Glu Leu Phe Asn Cys Val His Glu Leu Glu Leu Ile Tyr His Thr 
785                 790                 795                 800 


Phe Gly Arg His Asn Phe Lys Lys Thr Thr Ala Asn Leu Asp Leu Phe 
                805                 810                 815     


Leu Arg Arg Phe Asn Glu Ile Gln Phe Trp Val Val Thr Glu Ile Cys 
            820                 825                 830         


Leu Cys Ser Gln Leu Ser Lys Arg Val Gln Leu Leu Lys Lys Phe Ile 
        835                 840                 845             


Lys Ile Ala Ala His Cys Lys Glu Tyr Lys Asn Leu Asn Ser Phe Phe 
    850                 855                 860                 


Ala Ile Val Met Gly Leu Ser Asn Ile Ala Val Ser Arg Leu Ala Leu 
865                 870                 875                 880 


Thr Trp Glu Lys Leu Pro Ser Lys Phe Lys Lys Phe Tyr Ala Glu Phe 
                885                 890                 895     


Glu Ser Leu Met Asp Pro Ser Arg Asn His Arg Ala Tyr Arg Leu Thr 
            900                 905                 910         


Val Ala Lys Leu Glu Pro Pro Leu Ile Pro Phe Met Pro Leu Leu Ile 
        915                 920                 925             


Lys Asp Met Thr Phe Thr His Glu Gly Asn Lys Thr Phe Ile Asp Asn 
    930                 935                 940                 


Leu Val Asn Phe Glu Lys Met Arg Met Ile Ala Asn Thr Ala Arg Thr 
945                 950                 955                 960 


Val Arg Tyr Tyr Arg Ser Gln Pro Phe Asn Pro Asp Ala Ala Gln Ala 
                965                 970                 975     


Asn Lys Asn His Gln Asp Val Arg Ser Tyr Val Arg Gln Leu Asn Val 
            980                 985                 990         


Ile Asp Asn Gln Arg Thr Leu Ser  Gln Met Ser His Arg  Leu Glu Pro 
        995                 1000                 1005             


Arg Arg  Pro 
    1010     


<210>  679
<211>  3867
<212>  DNA
<213>  Homosapiens

<400>  679
actgtcttcc tcattggcgc cgtgcagaga ggcggaatgt tcaactccta actgcggcgg     60

aaacgtggga gccgcgcggg ccgctgtcgt cccaaccccc gccgccctcg tcgcgcgcgg    120

ggcctccgcg cccccggctg ctgctcacgc cccgcccggg agccagattt tgtggaagta    180

taatactttg tcattatgag atgtcgtctc tcggtgcctc ctttgtgcaa attaaatttg    240

atgacttgca gttttttgaa aactgcggtg gaggaagttt tgggagtgtt tatcgagcca    300

aatggatatc acaggacaag gaggtggctg taaagaagct cctcaaaata gagaaagagg    360

cagaaatact cagtgtcctc agtcacagaa acatcatcca gttttatgga gtaattcttg    420

aacctcccaa ctatggcatt gtcacagaat atgcttctct gggatcactc tatgattaca    480

ttaacagtaa cagaagtgag gagatggata tggatcacat tatgacctgg gccactgatg    540

tagccaaagg aatgcattat ttacatatgg aggctcctgt caaggtgatt cacagagacc    600

tcaagtcaag aaacgttgtt atagctgctg atggagtatt gaagatctgt gactttggtg    660

cctctcggtt ccataaccat acaacacaca tgtccttggt tggaactttc ccatggatgg    720

ctccagaagt tatccagagt ctccctgtgt cagaaacttg tgacacatat tcctatggtg    780

tggttctctg ggagatgcta acaagggagg tcccctttaa aggtttggaa ggattacaag    840

tagcttggct tgtagtggaa aaaaacgaga gattaaccat tccaagcagt tgccccagaa    900

gttttgctga actgttacat cagtgttggg aagctgatgc caagaaacgg ccatcattca    960

agcaaatcat ttcaatcctg gagtccatgt caaatgacac gagccttcct gacaagtgta   1020

actcattcct acacaacaag gcggagtgga ggtgcgaaat tgaggcaact cttgagaggc   1080

taaagaaact agagcgtgat ctcagcttta aggagcagga gcttaaagaa cgagaaagac   1140

gtttaaagat gtgggagcaa aagctgacag agcagtccaa caccccgctg ctgccttcct   1200

ttgagattgg tgcatggacg gaagacgatg tgtattgttg ggttcagcag ctcgtcagaa   1260

aaggtgactc ttcagcagag atgagtgtat atgcaagctt gtttaaagaa aacaacatta   1320

cagggaagcg gctgctgctg ctggaggaag aagacctgaa agacatgggc attgtctcca   1380

aggggcatat cattcacttc aagtcagcca ttgagaaatt aacccatgat tacataaatt   1440

tgtttcactt cccaccacta attaaggact caggaggtga acctgaagaa aatgaggaaa   1500

aaatagtgaa cctggaactg gtttttggtt ttcacttgaa accaggaact ggcccacagg   1560

attgtaagtg gaaaatgtat atggagatgg atggggatga aattgcaata acctacataa   1620

aagatgtgac attcaacact aacctacctg atgcggagat tttaaagatg acaaagccac   1680

catttgtaat ggagaagtgg attgtaggaa tagcaaaaag tcagactgtg gagtgcactg   1740

tcacatatga gagtgatgtt agaactccaa aaagcactaa acatgtccat tcgattcagt   1800

ggagtagaac aaaacctcag gatgaagtga aagcagtcca acttgccatt cagacattat   1860

tcaccaattc agatggcaac cctggaagca ggtccgactc aagtgctgat tgccagtggt   1920

tagatactct gaggatgcgg cagattgcat ccaacacttc tttacagcgt tcccagagca   1980

atcctattct ggggtcaccg ttcttctcac actttgatgg ccaggattcc tacgctgctg   2040

ctgtgagacg gccccaggtg cccattaagt atcaacagat tacacctgtg aaccagtcca   2100

gaagctcgtc tcctactcag tatggactga ccaaaaactt ctcttcccta catctcaact   2160

ctagggacag tggcttttcc agtggcaata ctgacacctc ttcagagagg ggtcgatact   2220

cagacagaag caggaacaaa tatggacgtg gtagtatatc actcaattct tctcctagag   2280

gaagatacag tggaaagagt cagcattcca ctccttcaag aggaagatac cctggaaagt   2340

tctacagggt ttctcagtca gcactcaatc ctcaccagtc gcctgacttc aagagaagcc   2400

ccagggacct ccaccaaccc aacaccatac cagggatgcc tttgcaccct gagactgact   2460

caagagccag tgaagaggac agcaaagtca gcgaaggggg ctggacaaaa gtggaatacc   2520

ggaaaaagcc ccacaggcca tctcccgcca aaaccaataa agagagagcc agaggggacc   2580

accgtggatg gagaaacttt tgatgaattg aactacatag cttttctaag caggttaaaa   2640

aaaaaaaaaa aaagaaatgt aatggttttt gataatatga tcccttcaga ttgaattaac   2700

gaaaagacaa cacttccagt ttttggattg ggaaatacct tctaattgag actatagcca   2760

aaccagggcc aaaattatgg atattggtca cccagtgatc ataactaggc ttgaaaatca   2820

ctacacatat tttctgcctt gagtgaacat ttttagagga aaggttatgc catcttttta   2880

ccctaaccac tgatattctg gttagcaggg ccaggacaag gggaaggaaa atgaggtcaa   2940

caaaaaaatc aaatttttag gaaaagataa gatgaatgtt actgattttt ccttttggct   3000

gaggctgcaa tatggcctgg caaggcactg ttactgatct tgtctttaac attttgatat   3060

tttgttcatc ataatttttg catttatttt tttaaatatt gcattaaaat atcatttagc   3120

ttgattatcg agttttttgg tttgaggttt tttgttgctt cttttttctt ttctttcttt   3180

ccccctcttt tttttggatg tccccttaaa ttttgtgccc aaggcaggta cctcactcat   3240

ctcatccttg gctcagccct gctggttagt atttagtatt tattttagta agatatttgt   3300

gtctgtatga tggtcagagt tgaactgatc tggcttgtca tttttcagta ataaaaaaag   3360

ttactgaatt taatgttgaa tatgatgcat atctcattca ttacgattta tcagaaacca   3420

aagatttaaa ttgcctagat ttgtggttct ttctcttcct aagttcccag cgactgcttt   3480

caaatactat tttctaaatt tcaccaaagg agcaaagagg ataaaacaac actccataaa   3540

ggcctcttgg gatgtcagaa atctaaaatc taaaagaaaa cagacacaga gcaagacaat   3600

aacatcacaa gctaaaagcc agagaaattt aaaattacca acatccttgt tggagtaaga   3660

cagtaaatat cagccttgca gcaagacagc tctgagcagc tgtgggcaaa gaggtaaacc   3720

agtgggggtg caaggagact gtctgcagct tagggcagaa atggtgggat ccaacttgtg   3780

aaatgcttca tgttttacaa accaaaaagt caggtagcaa caaacttatt gtatgtcaaa   3840

tcaataaatg ttactttcaa taaaaaa                                       3867


<210>  680
<211>  800
<212>  PRT
<213>  Homosapiens

<400>  680

Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu 
        275                 280                 285             


Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys 
    290                 295                 300                 


Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln 
305                 310                 315                 320 


Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Pro Ser Phe Glu Ile 
                325                 330                 335     


Gly Ala Trp Thr Glu Asp Asp Val Tyr Cys Trp Val Gln Gln Leu Val 
            340                 345                 350         


Arg Lys Gly Asp Ser Ser Ala Glu Met Ser Val Tyr Ala Ser Leu Phe 
        355                 360                 365             


Lys Glu Asn Asn Ile Thr Gly Lys Arg Leu Leu Leu Leu Glu Glu Glu 
    370                 375                 380                 


Asp Leu Lys Asp Met Gly Ile Val Ser Lys Gly His Ile Ile His Phe 
385                 390                 395                 400 


Lys Ser Ala Ile Glu Lys Leu Thr His Asp Tyr Ile Asn Leu Phe His 
                405                 410                 415     


Phe Pro Pro Leu Ile Lys Asp Ser Gly Gly Glu Pro Glu Glu Asn Glu 
            420                 425                 430         


Glu Lys Ile Val Asn Leu Glu Leu Val Phe Gly Phe His Leu Lys Pro 
        435                 440                 445             


Gly Thr Gly Pro Gln Asp Cys Lys Trp Lys Met Tyr Met Glu Met Asp 
    450                 455                 460                 


Gly Asp Glu Ile Ala Ile Thr Tyr Ile Lys Asp Val Thr Phe Asn Thr 
465                 470                 475                 480 


Asn Leu Pro Asp Ala Glu Ile Leu Lys Met Thr Lys Pro Pro Phe Val 
                485                 490                 495     


Met Glu Lys Trp Ile Val Gly Ile Ala Lys Ser Gln Thr Val Glu Cys 
            500                 505                 510         


Thr Val Thr Tyr Glu Ser Asp Val Arg Thr Pro Lys Ser Thr Lys His 
        515                 520                 525             


Val His Ser Ile Gln Trp Ser Arg Thr Lys Pro Gln Asp Glu Val Lys 
    530                 535                 540                 


Ala Val Gln Leu Ala Ile Gln Thr Leu Phe Thr Asn Ser Asp Gly Asn 
545                 550                 555                 560 


Pro Gly Ser Arg Ser Asp Ser Ser Ala Asp Cys Gln Trp Leu Asp Thr 
                565                 570                 575     


Leu Arg Met Arg Gln Ile Ala Ser Asn Thr Ser Leu Gln Arg Ser Gln 
            580                 585                 590         


Ser Asn Pro Ile Leu Gly Ser Pro Phe Phe Ser His Phe Asp Gly Gln 
        595                 600                 605             


Asp Ser Tyr Ala Ala Ala Val Arg Arg Pro Gln Val Pro Ile Lys Tyr 
    610                 615                 620                 


Gln Gln Ile Thr Pro Val Asn Gln Ser Arg Ser Ser Ser Pro Thr Gln 
625                 630                 635                 640 


Tyr Gly Leu Thr Lys Asn Phe Ser Ser Leu His Leu Asn Ser Arg Asp 
                645                 650                 655     


Ser Gly Phe Ser Ser Gly Asn Thr Asp Thr Ser Ser Glu Arg Gly Arg 
            660                 665                 670         


Tyr Ser Asp Arg Ser Arg Asn Lys Tyr Gly Arg Gly Ser Ile Ser Leu 
        675                 680                 685             


Asn Ser Ser Pro Arg Gly Arg Tyr Ser Gly Lys Ser Gln His Ser Thr 
    690                 695                 700                 


Pro Ser Arg Gly Arg Tyr Pro Gly Lys Phe Tyr Arg Val Ser Gln Ser 
705                 710                 715                 720 


Ala Leu Asn Pro His Gln Ser Pro Asp Phe Lys Arg Ser Pro Arg Asp 
                725                 730                 735     


Leu His Gln Pro Asn Thr Ile Pro Gly Met Pro Leu His Pro Glu Thr 
            740                 745                 750         


Asp Ser Arg Ala Ser Glu Glu Asp Ser Lys Val Ser Glu Gly Gly Trp 
        755                 760                 765             


Thr Lys Val Glu Tyr Arg Lys Lys Pro His Arg Pro Ser Pro Ala Lys 
    770                 775                 780                 


Thr Asn Lys Glu Arg Ala Arg Gly Asp His Arg Gly Trp Arg Asn Phe 
785                 790                 795                 800 


<210>  681
<211>  7194
<212>  DNA
<213>  Homosapiens

<400>  681
actgtcttcc tcattggcgc cgtgcagaga ggcggaatgt tcaactccta actgcggcgg     60

aaacgtggga gccgcgcggg ccgctgtcgt cccaaccccc gccgccctcg tcgcgcgcgg    120

ggcctccgcg cccccggctg ctgctcacgc cccgcccggg agccagattt tgtggaagta    180

taatactttg tcattatgag atgtcgtctc tcggtgcctc ctttgtgcaa attaaatttg    240

atgacttgca gttttttgaa aactgcggtg gaggaagttt tgggagtgtt tatcgagcca    300

aatggatatc acaggacaag gaggtggctg taaagaagct cctcaaaata gagaaagagg    360

cagaaatact cagtgtcctc agtcacagaa acatcatcca gttttatgga gtaattcttg    420

aacctcccaa ctatggcatt gtcacagaat atgcttctct gggatcactc tatgattaca    480

ttaacagtaa cagaagtgag gagatggata tggatcacat tatgacctgg gccactgatg    540

tagccaaagg aatgcattat ttacatatgg aggctcctgt caaggtgatt cacagagacc    600

tcaagtcaag aaacgttgtt atagctgctg atggagtatt gaagatctgt gactttggtg    660

cctctcggtt ccataaccat acaacacaca tgtccttggt tggaactttc ccatggatgg    720

ctccagaagt tatccagagt ctccctgtgt cagaaacttg tgacacatat tcctatggtg    780

tggttctctg ggagatgcta acaagggagg tcccctttaa aggtttggaa ggattacaag    840

tagcttggct tgtagtggaa aaaaacgaga gattaaccat tccaagcagt tgccccagaa    900

gttttgctga actgttacat cagtgttggg aagctgatgc caagaaacgg ccatcattca    960

agcaaatcat ttcaatcctg gagtccatgt caaatgacac gagccttcct gacaagtgta   1020

actcattcct acacaacaag gcggagtgga ggtgcgaaat tgaggcaact cttgagaggc   1080

taaagaaact agagcgtgat ctcagcttta aggagcagga gcttaaagaa cgagaaagac   1140

gtttaaagat gtgggagcaa aagctgacag agcagtccaa caccccgctt ctcttgcctc   1200

ttgctgcaag aatgtctgag gagtcttact ttgaatctaa aacagaggag tcaaacagtg   1260

cagagatgtc atgtcagatc acagcaacaa gtaacgggga gggccatggc atgaacccaa   1320

gtctgcaggc catgatgctg atgggctttg gggatatctt ctcaatgaac aaagcaggag   1380

ctgtgatgca ttctgggatg cagataaaca tgcaagccaa gcagaattct tccaaaacca   1440

catctaagag aagggggaag aaagtcaaca tggctctggg gttcagtgat tttgacttgt   1500

cagaaggtga cgatgatgat gatgatgacg gtgaggagga ggataatgac atggataata   1560

gtgaatgaaa gcagaaagca aagtaataaa atcacaaatg tttggaaaac acaaaagtaa   1620

cttgtttatc tcagtctgta caaaaacagt aaggaggcag aaagccaagc actgcatttt   1680

taggccaatc acatttacat gaccgtaatt tcttatcaat tctactttta tttttgctta   1740

cagaaaaacg gggggagaat taagccaaag aagtatattt atgaatcagc aaatgtggtg   1800

cctgattata gaaatttgtg atcctatata caatatagga cttttaaagt tgtgacattc   1860

tggctttttc ttttaatgaa tactttttag tttgtatttg actttatttc ctttattcaa   1920

atcattttta aaaacttaca ttttgaacaa acactcttaa ctcctaattg ttctttgaca   1980

cgtagtaatt ctgtgacata cttttttttt cttatagcaa tacactgtaa tatcagaaat   2040

ggttggcctg agcaacctag taagacctcg tctctactaa taattaaaaa actagctggc   2100

atggtagcac acacctgtag tcccagatac ttgggaggcc aaggcaggag gattgcttga   2160

gacctagcaa tcagtcaggg ctgcagtgag ccatgatggc accactgcac tctagcctgg   2220

gcaagagaac aagatcctgt ctcaaaaaac aaaaaaaaga aagaattgat agtacaaaat   2280

ccaacaacaa tactgagatg atctaagaag gttataacaa aatgctcttc agaaatacct   2340

aagtgctgag aatttttagt actaaagagc acagctgctc aaagtaaagc ctgagcagtg   2400

ttctcagtaa tgtatttgaa ggaaaaatac cctgatttga aaccaacagc agatgttgca   2460

aactttcata ccactgctgg ccatggaagc ctcttaacaa cacactgtca tttaaggctg   2520

tgcttgtgct ttatacaaag agaaagaggt ggtcttaagg ggatgcttcc aggggggtga   2580

gttcatgcct ctcctgtatt ttccagcaag tggggtatgt gtggtggttt gttttttaga   2640

ggggcataat aatccaggat tctaagcata tgctcagcta ttttaaagag gaaattaaat   2700

attataaaag aaatagtaaa gataagttat cctcacttag gcaaaagcac aggtcctttc   2760

catatcaagt ttagcctacc agggttgttt tttgttttaa ccctgcttaa taatgttggt   2820

gttttagaag tagatacagg cactgctctg aaaacctggc tagccaagga tattctcaga   2880

atgttatcac ctgtttgtca aagcttgttt aaattataaa acacttttaa ttatatatat   2940

gaggcaaaag aactaagact tttttcaaac taaattagaa aggagtgtca ttatttgact   3000

gttaaaccaa aatatttttg gtgggtcttt ttatggaagt ttaaagaaag gacatcatca   3060

tagatatgat ctaacagtat ttctaactat atttgatcat taaaagcctc ttggaatttg   3120

aagcgtgacg tgtttctaat gccccttgag aggtgaaaaa taccacataa tgatcagtat   3180

gctgtgccag cttcatttgg ggagaaataa ctagtagaaa gttctgggtg tgaggtgtac   3240

agcagtctag gtggcatagt gatgaagaaa gggatcagag tctgactgtc actcagaatc   3300

ctgggctcag ttgcttgaca accttgggaa aattgtttta tctttgtgcg tctgtttgct   3360

gatcttcagc gtgggaataa taacagtacc tacttgaaag gatcattgtg cggattaaaa   3420

gaaataatat atgtaaagca ctttaacaca gcaccaggcc cacggaaagt ggctaatgtt   3480

agctactatg aatggtgcca gtgaagacac tgaaaaataa gtgatttcag taaccttctg   3540

gaaagctatc agtttcaaat aatattttct ctgtagtatg agatgaaatt aaaagtggat   3600

agctttcagg aaagataaag agaacatgct tagaatgtaa gctaaacaga ttttttctgt   3660

tgctctttga aaactatgag ccctggccag cttaacctgg tctgaggtga gactaaacac   3720

aaaaacagta gataaatctc tccctaaaag atggattccc ccacataccc atgctactag   3780

tttctctgtc tattcacaca tatgtacaaa tacatgaaca cagcctgtct gtgctcagac   3840

atagagaagt actacctgac ttgagtcaat gcacccaaga agaaaagctt ggagtagagc   3900

agaagggagg gcttgggact cctgtctttc cagcatgccc tggggtgcag tggtcagcca   3960

cctgaagaga gagccaatag catggggttt acaaggcaaa gatagtcatt cattcaacac   4020

atattcatag agctccttct ctgtgccaga cactgttctg gaagatagct agatgaaaat   4080

ctttgcactc acagagctta catgccagtg agtgaagatc gatgataaat aaagcaaatg   4140

catcatatgt tcacatttga taagtatatg ccaaaaaatg aagccgggaa ggaggacaag   4200

gcccatgggt gggtgttgag gtttttaaag tgtggtcagg aaaggcccca ctgataaggt   4260

aacatttgag caagtctgaa aaaggcaagg ggatctttgg ggctaacttc gggatccctg   4320

cactttatgt aagaatgtaa acctggagtc tcatttaaga atgatcagca atacgtttag   4380

aacatatgaa ctgaatgaaa tggacatttt ttcttaattt atgtataaat ccatatgatt   4440

atacataaag ttctgatgca ttaataaaag cagccaaata gggccaaaga gaaaaataac   4500

aggactctgt actggaccta actttatcat taattaggta atattttcct catttcttta   4560

ctgctgccat tttcctcacc agtattccag agatggtcat agctcattac tctaccacca   4620

agaacctaaa aggaattaga atacagcaga attggcctca gtgaagagct taaaattgtt   4680

ctcctcgtag aactggacta ttgatcatta ccacgtgacg ttggctctat tactttctgt   4740

tcccaatgtc cttctagtgg tttgaaaatg ttaaaacatc cctaaaatct aaatcatata   4800

atcagaattc tatagtgtcc cactctatct gtaaagatca tttggaagac tttagactct   4860

attaatttta aaaggaatat ttattagcca tatgcagaat ttctaatgat gatattgtac   4920

agcttctaat tcacttttca gatcagtgtt tgaaatggca attatcagtg ttggatttag   4980

ttccaactac ttgatttaca aaaatgtaca tttagaggtt aaaagaaaca gtgagaaatg   5040

taaacattca aaatgataat tgaatctctc agttgtggga ataattatca gagacatgca   5100

actgaaaatg tctcaccttt catctttttt tcttaattca taaagttatc ttgtagaatt   5160

tgatgagacc ctccctagtc attctcaact ggggcggtgc tgtcaccgaa tggtgtttga   5220

gagtgttggg gctagggcac atttttggtt gtcacagcaa ctggggtggc atttgctgcc   5280

cagtgccagg aatagtaaca ttatgaatgc cagggacagt gtgctcagta aagtcttcca   5340

tccaaaaggg gcagggcacg gtggctcacg cctgtaatcc cagcactttg ggaggccaag   5400

gtgggcggat cacctgatgt caggggttcg agaccagcct ggccaacatg gtgaaaccct   5460

gttgctacta aaaatacaaa aattggctgg gtgtggtgtc acatgccagt aaccccagct   5520

actagggagg ctgaggcagg agaatcactt gaacccggga ggcagaggtt gcagtgagct   5580

gagattgcac cactacactc cagcctggat gacagagtga gacttcatct caaaaaaaaa   5640

aaaaaacaaa aaaaaacaac ccggtagcat tgtcccttcc ccactgacaa acttatcaaa   5700

tccagaagct ttagagtttc gtctctaatt atttttctcc tgaacaaaat tacccaagtc   5760

aaaacaaaat gtatttttag aattacggca gcatacgacc tgaattttgt gagtttcgtg   5820

gctttatctt aaatcaccat ttccctaaaa atggtttctt tctccttaga aatgctggtg   5880

gcaacttgat gaaacagcca aatgcaccag ggcaggtcac tttcccatta cactgattcc   5940

acaattaaaa aaaaaaaaga aaaaaaactc attgagatag ctacagttct ataggttaat   6000

ttaaagcctc ctttttctac tcatttttga aagcaaaatt acattttact attttacata   6060

accagtgaaa agacgttgaa agcctacagc tcactgtttt tggtgctctg gaaatgttga   6120

gggtgggttt ttaaccagtg atttttaacg tgcagtgaat ttgttagact tttaaacacc   6180

agctaaggta gtcaaacttg atccccatta aaaatcaagg aattaggggt cgggggaggg   6240

tttaggagtg atccagaatg acctcccaga attactgtgc gtacaacttt atttttcaga   6300

gttttcattg gaatggtaag agttttatga aagacagttt taaaacttat tctgagttaa   6360

atattaatac tttaaaaaat tattgtacta gacttattgc agccttttga aagtagcaga   6420

gtttcatcat accacatata taacagagca taaattttct ataatcaggc accttttgct   6480

gcttttgagt aagactgttt tcctgtttaa gtgttaagca tcgccagaca taaaaatcta   6540

ttctctcctc tcgattgtag catagcctga cagctctaga tacagcattt ctatgatgaa   6600

aaatgagtat ccatcaggaa atctagaaga ctagccgtgt tttctcagac tccacctttg   6660

tttgcactct gttgcctgtg aggagctttc tggcatgtga ttatttactt caaaactaga   6720

gttccaagca cctacattaa ttattttata ttgtgtgcag aatagtatat cttttaatgt   6780

cagatatgat acactgcaca tattgctttt gcactcttaa aatttttgta ctaaataata   6840

gaaaatattt atattctttg agtgtgagct ttgaatagat ggcattatca ctttattgtt   6900

tttttaacaa aaactttttc tcaattattc tattgcaatg ttattctgag caagtcctat   6960

gccaaatatc ttgtataatg tttgtatgga agattaaatt ttactcttgt gtggtaagac   7020

tatttcagtt actgatttta tagttggaat ttgatattcc agcacaaagt ccacagtgta   7080

ttcagaaatc caagttggtg tcatacattt cattttgatg tgaacttttc tttgctttcc   7140

tttgttctaa gactccattt tgcaataaac gttttgacag taaaaaaaaa aaaa         7194


<210>  682
<211>  455
<212>  PRT
<213>  Homosapiens

<400>  682

Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu 
        275                 280                 285             


Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys 
    290                 295                 300                 


Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln 
305                 310                 315                 320 


Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Leu Pro Leu Ala Ala 
                325                 330                 335     


Arg Met Ser Glu Glu Ser Tyr Phe Glu Ser Lys Thr Glu Glu Ser Asn 
            340                 345                 350         


Ser Ala Glu Met Ser Cys Gln Ile Thr Ala Thr Ser Asn Gly Glu Gly 
        355                 360                 365             


His Gly Met Asn Pro Ser Leu Gln Ala Met Met Leu Met Gly Phe Gly 
    370                 375                 380                 


Asp Ile Phe Ser Met Asn Lys Ala Gly Ala Val Met His Ser Gly Met 
385                 390                 395                 400 


Gln Ile Asn Met Gln Ala Lys Gln Asn Ser Ser Lys Thr Thr Ser Lys 
                405                 410                 415     


Arg Arg Gly Lys Lys Val Asn Met Ala Leu Gly Phe Ser Asp Phe Asp 
            420                 425                 430         


Leu Ser Glu Gly Asp Asp Asp Asp Asp Asp Asp Gly Glu Glu Glu Asp 
        435                 440                 445             


Asn Asp Met Asp Asn Ser Glu 
    450                 455 


<210>  683
<211>  570
<212>  DNA
<213>  Homosapiens

<400>  683
atgtccaaag ttgtctctca ctgtttttat ttaaaggaac tagacacaaa cctggctgct     60

ttaaccacgg cctctgggag ggctacagct gagaaaatcc gctgtcagga agaagtgaat    120

agaactaaca agactattga gcgcgccaac agattagtga aaggtctgga gaaggaaaat    180

gatttgaaaa tcgagttgaa aattcagcta ggagatgagt tcttcatctg cctttcctct    240

gtgcaaggca cccaaagtga gagcagcagg gcgcagcagt gcccagagct gactgatggc    300

atcaggaaat ctagctcatc ccaaccacag gcagttttta aaattggggt tgtggctccc    360

cctgctaaag cgacattacc cacggacctt gttaccaacc ttggcgacca gagaacgctg    420

atctccaaag gtctagaccc ggtgaaacag cgttcggtgg ccactgaccg gtttccagag    480

tcagagctcc ccctgctgga atccaaagca cgtcgtaacc ctgtctggac gtattttatt    540

ccacaagacc gtgcagccct gattgagtga                                     570


<210>  684
<211>  189
<212>  PRT
<213>  Homosapiens

<400>  684

Met Ser Lys Val Val Ser His Cys Phe Tyr Leu Lys Glu Leu Asp Thr 
1               5                   10                  15      


Asn Leu Ala Ala Leu Thr Thr Ala Ser Gly Arg Ala Thr Ala Glu Lys 
            20                  25                  30          


Ile Arg Cys Gln Glu Glu Val Asn Arg Thr Asn Lys Thr Ile Glu Arg 
        35                  40                  45              


Ala Asn Arg Leu Val Lys Gly Leu Glu Lys Glu Asn Asp Leu Lys Ile 
    50                  55                  60                  


Glu Leu Lys Ile Gln Leu Gly Asp Glu Phe Phe Ile Cys Leu Ser Ser 
65                  70                  75                  80  


Val Gln Gly Thr Gln Ser Glu Ser Ser Arg Ala Gln Gln Cys Pro Glu 
                85                  90                  95      


Leu Thr Asp Gly Ile Arg Lys Ser Ser Ser Ser Gln Pro Gln Ala Val 
            100                 105                 110         


Phe Lys Ile Gly Val Val Ala Pro Pro Ala Lys Ala Thr Leu Pro Thr 
        115                 120                 125             


Asp Leu Val Thr Asn Leu Gly Asp Gln Arg Thr Leu Ile Ser Lys Gly 
    130                 135                 140                 


Leu Asp Pro Val Lys Gln Arg Ser Val Ala Thr Asp Arg Phe Pro Glu 
145                 150                 155                 160 


Ser Glu Leu Pro Leu Leu Glu Ser Lys Ala Arg Arg Asn Pro Val Trp 
                165                 170                 175     


Thr Tyr Phe Ile Pro Gln Asp Arg Ala Ala Leu Ile Glu 
            180                 185                 


<210>  685
<211>  4255
<212>  DNA
<213>  Homosapiens

<400>  685
ggtctgcgcg caggtgccgc tcggcgcccg gcccgcccgt tccgccgctg tcgccgccgt     60

cgtgcgtgcc gctcggcgga ggggacgggc ctgcgttctc tcctccttcc tccccgcctc    120

cagctgccgg caggaccttt ctctcgctgc cgctgggacc ccgtgtcatc gcccaggccg    180

agcacggaaa tctactttct tcaatgtgtt aaccaatagt caggcttcag cagaaaactt    240

cccgttctgc actattgatc ctaatgagag cagagtacct gtgccagatg aaaggtttga    300

ctttctttgt caataccaca aaccagcaag caaaattcct gcctttctaa atgtggtgga    360

tattgctggc cttgtgaaag gagctcacaa tgggcagggc ctggggaatg cttttttatc    420

tcatattagt gcctgtgatg gcatctttca tctaacacgt gcttttgaag atgatgatat    480

cacgcacgtt gaaggaagtg tagatcctat tcgagatata gaaataatac atgaagagct    540

tcagcttaaa gatgaggaaa tgattgggcc cattatagat aaactagaaa aggtggctgt    600

gagaggagga gataaaaaac taaaacctga atatgatata atgtgcaaag taaaatcctg    660

ggttatagat caaaagaaac ctgttcgctt ctatcatgat tggaatgaca aagagattga    720

agtgttgaat aaacacttat ttttgacttc aaaaccaatg gtctacttgg ttaatctttc    780

tgaaaaagac tacattagaa agaaaaacaa atggttgata aaaattaaag agtgggtgga    840

caagtatgac ccaggtgctt tggtcattcc ttttagtggg gccttggaac tcaagttgca    900

agaattgagt gctgaggaga gacagaagta tctggaagcg aacatgacac aaagtgcttt    960

gccaaagatc attaaggctg ggtttgcagc actccaacta gaatactttt tcactgcagg   1020

cccagatgaa gtgcgtgcat ggaccatcag gaaagggact aaggctcctc aggctgcagg   1080

aaagattcac acagattttg aaaagggatt cattatggct gaagtaatga aatacgaaga   1140

ttttaaagag gaaggttctg aaaatgcagt caaggctgct ggaaagtaca gacaacaagg   1200

cagaaattat attgttgaag atggagatat tatcttcttc aaatttaaca cacctcaaca   1260

accgaagaag aaataaaatt tagttattgc tcagataaac atacaacttc caaaaggcat   1320

ctgattttta aaaaattaaa atttctgaaa accaatgcga caaataaagt tggggagatg   1380

ggaatctttg acaaacaaat tatttttatt tgttttaaaa ttaaaatact gtgtaccccc   1440

ccccccccat gaaatgcagg ttcactaaat gtgaacagct ttgcttttca cgtgattaag   1500

accctactcc aaattgtaga agcttttcag gaaccatatt actctcatga tacttcatta   1560

atctccatca tgtatgccaa gcctgacaca tttgacagtg aggacaatgt ggcttgctcc   1620

tttttgaatc tacagataat gcatgtttta cagtactcca gatgtctaca ctcaataaaa   1680

catttgacaa aaccagcctt ggtgtgtttg gggatgtctg tattgactga ctgtggtgtg   1740

ctgaatgcga tacggcacct ggtggttgct gattacagaa ttttaaggcg tgtgtatgac   1800

acagtaactg gcagtgtggg gcagctgcaa ttgtatctta aaagtgagtc tttcatggga   1860

atcagaagaa tagtatacca gggatttgtc tcaaaaaagt taattaattt atagatcaac   1920

atttattgaa agatgatagc aatgatatta tgagggatat gagataggtg actgaccaca   1980

aagaagaaaa ttctgtctca aaaattaaag aattttgttt gttattgttg ttctgaccat   2040

attgaaaaga ggttcacttt taatctttcc tttgaaatta ttaaattgta aaaactgacc   2100

cattgatgtc tggtgggtta tgttttgctt caattcagca atgtgtataa aagttcctac   2160

actgattttg aaatactaag atcagacttt gaaaatttta aaaattcttt cattcttact   2220

tttcagatat ttgagagcag tcgaagtggt agtatgggta agttaagcac ttcttaacat   2280

tgtagcagaa aattccaaaa gaaagactag aacaaattgg taatttggag accctttgcc   2340

acttagcctt ctcttgtgat gatggcctga aagctctctc ggccctgagc ctccctttct   2400

ctcccatgtt tccattcctg tgagacctcc cttccttgtc cttgtcctct gcccttttgt   2460

gctcttctgt gatcacagga ccatttccat ggaatgcaga ttcataccca gccagccttt   2520

gcctctactg tatcgctttg ggactttaaa gatgcagaag tattagaaca cacacaaact   2580

taaaatggaa agttaccaaa tgtagcacta gaggcaagaa aaggggtgat tttttaaaga   2640

tttggctata cttaagatat ttaaagagga tgaggttgag tcgtgagtat aatttagaag   2700

ctctccagtg agtatttttt tagtatcaaa tagtgatctt cttttgctaa cataaaaatg   2760

agtaaactac agcagagaaa taagaataaa actaatgaag ggttttttaa aagaactaaa   2820

taaaacaaat aaaactaggc tacaggtata gctgaccaag tttgctgtga aaaatccttg   2880

ttatatctat ttctgtattg gagtaatgtg tagattagtg gattgttagg gatttcagca   2940

gtataagaaa gaatcaaata tcttgctttt gggtcttctc caaagtaaat tgcatggact   3000

tcttaaagaa gtttgaaatc agtaaaaaga cattaggatc atgcaatttt actttgtcta   3060

gcttctaatg tggtaaattg cacattgtgc aacagaacca ttaataaaag aaaggagtta   3120

gttttgaggt aactgcattc attaggggct gaaaataaat gttaaaaatg tttaatttgg   3180

ttagaagttc tacaacattg tatgtacata tacaaaattt cattttctct gaaagtcgag   3240

aattccaaga actgttacat ataatcatat atatgcctat atctaaacgt tttccctcct   3300

ttaatattga taaagttaat atattttagg atgttatgta aatatttttg catgtatctg   3360

tagctccatc ttaatcaaat ttatggttaa aagagatttg aggccaggcg tggaggctca   3420

cacctataat cccaacactt tgggaggccg aggtgggagg atcacttgag cacaggagtt   3480

tgagaccagc ctgtgcaaca tcatgaaaca tcatctctac ataaaaaaat acatatatac   3540

aaaaattagc tgggcatcat ggcacacacc tgtagtccca gctacttagg aggctgagat   3600

gggaggattg atcgatcgct tgagcctggg aggtggaggc tactgtgagc catgatcatg   3660

ccactgcact ccagcctggg caacagagtg agaccctgtc tccaaagaga aagagaaact   3720

tgagaaggct tgtgcccaaa gcttgaagaa agattgtaat agcatttagt tgtgttttat   3780

catgttatct tcataacatg cattttgcat atggctcaga gcagagccgg atctcccaag   3840

gaagcacaaa tagtttttgt cgctaactta gttatgagtg aagcctctgt tcacttataa   3900

cttgccagtt tcattggtgg aataagtccc cttactcatg attcatcaat attcctatat   3960

taaaattcca gtttgatgtt tgtctctagt tgtctgtgta taatatttcc aaagctcctt   4020

tgtaaacccc gtctcctttc attcagagag tcagagacgg tatctcctcc tcctgcctct   4080

tctattgttc tgattagtct acttaaattc acttgatgct ctttttattt tacaagagac   4140

ttgagaaatg tcggttgttc ctaatggcaa actactttag ctgggaaaat tcatttcaac   4200

ttattttaag cttgtaaaat acactgtggt gataaaataa aagagctggg tttga        4255


<210>  686
<211>  238
<212>  PRT
<213>  Homosapiens

<400>  686

Met Ile Gly Pro Ile Ile Asp Lys Leu Glu Lys Val Ala Val Arg Gly 
1               5                   10                  15      


Gly Asp Lys Lys Leu Lys Pro Glu Tyr Asp Ile Met Cys Lys Val Lys 
            20                  25                  30          


Ser Trp Val Ile Asp Gln Lys Lys Pro Val Arg Phe Tyr His Asp Trp 
        35                  40                  45              


Asn Asp Lys Glu Ile Glu Val Leu Asn Lys His Leu Phe Leu Thr Ser 
    50                  55                  60                  


Lys Pro Met Val Tyr Leu Val Asn Leu Ser Glu Lys Asp Tyr Ile Arg 
65                  70                  75                  80  


Lys Lys Asn Lys Trp Leu Ile Lys Ile Lys Glu Trp Val Asp Lys Tyr 
                85                  90                  95      


Asp Pro Gly Ala Leu Val Ile Pro Phe Ser Gly Ala Leu Glu Leu Lys 
            100                 105                 110         


Leu Gln Glu Leu Ser Ala Glu Glu Arg Gln Lys Tyr Leu Glu Ala Asn 
        115                 120                 125             


Met Thr Gln Ser Ala Leu Pro Lys Ile Ile Lys Ala Gly Phe Ala Ala 
    130                 135                 140                 


Leu Gln Leu Glu Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Arg Ala 
145                 150                 155                 160 


Trp Thr Ile Arg Lys Gly Thr Lys Ala Pro Gln Ala Ala Gly Lys Ile 
                165                 170                 175     


His Thr Asp Phe Glu Lys Gly Phe Ile Met Ala Glu Val Met Lys Tyr 
            180                 185                 190         


Glu Asp Phe Lys Glu Glu Gly Ser Glu Asn Ala Val Lys Ala Ala Gly 
        195                 200                 205             


Lys Tyr Arg Gln Gln Gly Arg Asn Tyr Ile Val Glu Asp Gly Asp Ile 
    210                 215                 220                 


Ile Phe Phe Lys Phe Asn Thr Pro Gln Gln Pro Lys Lys Lys 
225                 230                 235             


<210>  687
<211>  4356
<212>  DNA
<213>  Homosapiens

<400>  687
ggtctgcgcg caggtgccgc tcggcgcccg gcccgcccgt tccgccgctg tcgccgccgt     60

cgtgcgtgcc gctcggcgga ggggacgggc ctgcgttctc tcctccttcc tccccgcctc    120

cagctgccgg caggaccttt ctctcgctgc cgctgggacc ccgtgtcatc gcccaggccg    180

agcacgatgc cccctaaaaa gggaggtgat ggaattaaac cacccccaat cattggaaga    240

tttggaacct cactgaaaat tggtattgtt ggattgccaa atgttgggaa atctactttc    300

ttcaatgtgt taaccaatag tcaggcttca gcagaaaact tcccgttctg cactattgat    360

cctaatgaga gcagagtacc tgtgccagat gaaaggtttg actttctttg tcaataccac    420

aaaccagcaa gcaaaattcc tgcctttcta aatgtggtgg atattgctgg ccttgtgaaa    480

ggagctcaca atgggcaggg cctggggaat gcttttttat ctcatattag tgcctgtgat    540

ggcatctttc atctaacacg tgcttttgaa gatgatgata tcacgcacgt tgaaggaagt    600

gtagatccta ttcgagatat agaaataata catgaagagc ttcagcttaa agatgaggaa    660

atgattgggc ccattataga taaactagaa aaggtggctg tgagaggagg agataaaaaa    720

ctaaaacctg aatatgatat aatgtgcaaa gtaaaatcct gggttataga tcaaaagaaa    780

cctgttcgct tctatcatga ttggaatgac aaagagattg aagtgttgaa taaacactta    840

tttttgactt caaaaccaat ggtctacttg gttaatcttt ctgaaaaaga ctacattaga    900

aagaaaaaca aatggttgat aaaaattaaa gagtgggtgg acaagtatga cccaggtgct    960

ttggtcattc cttttagtgg ggccttggaa ctcaagttgc aagaattgag tgctgaggag   1020

agacagaagt atctggaagc gaacatgaca caaagtgctt tgccaaagat cattaaggct   1080

gggtttgcag cactccaact agaatacttt ttcactgcag gcccagatga agtgcgtgca   1140

tggaccatca ggaaagggac taaggctcct caggctgcag gaaagattca cacagatttt   1200

gaaaagggat tcattatggc tgaagtaatg aaatacgaag attttaaaga ggaaggttct   1260

gaaaatgcag tcaaggctgc tggaaagtac agacaacaag gcagaaatta tattgttgaa   1320

gatggagata ttatcttctt caaatttaac acacctcaac aaccgaagaa gaaataaaat   1380

ttagttattg ctcagataaa catacaactt ccaaaaggca tctgattttt aaaaaattaa   1440

aatttctgaa aaccaatgcg acaaataaag ttggggagat gggaatcttt gacaaacaaa   1500

ttatttttat ttgttttaaa attaaaatac tgtgtacccc ccccccccca tgaaatgcag   1560

gttcactaaa tgtgaacagc tttgcttttc acgtgattaa gaccctactc caaattgtag   1620

aagcttttca ggaaccatat tactctcatg atacttcatt aatctccatc atgtatgcca   1680

agcctgacac atttgacagt gaggacaatg tggcttgctc ctttttgaat ctacagataa   1740

tgcatgtttt acagtactcc agatgtctac actcaataaa acatttgaca aaaccagcct   1800

tggtgtgttt ggggatgtct gtattgactg actgtggtgt gctgaatgcg atacggcacc   1860

tggtggttgc tgattacaga attttaaggc gtgtgtatga cacagtaact ggcagtgtgg   1920

ggcagctgca attgtatctt aaaagtgagt ctttcatggg aatcagaaga atagtatacc   1980

agggatttgt ctcaaaaaag ttaattaatt tatagatcaa catttattga aagatgatag   2040

caatgatatt atgagggata tgagataggt gactgaccac aaagaagaaa attctgtctc   2100

aaaaattaaa gaattttgtt tgttattgtt gttctgacca tattgaaaag aggttcactt   2160

ttaatctttc ctttgaaatt attaaattgt aaaaactgac ccattgatgt ctggtgggtt   2220

atgttttgct tcaattcagc aatgtgtata aaagttccta cactgatttt gaaatactaa   2280

gatcagactt tgaaaatttt aaaaattctt tcattcttac ttttcagata tttgagagca   2340

gtcgaagtgg tagtatgggt aagttaagca cttcttaaca ttgtagcaga aaattccaaa   2400

agaaagacta gaacaaattg gtaatttgga gaccctttgc cacttagcct tctcttgtga   2460

tgatggcctg aaagctctct cggccctgag cctccctttc tctcccatgt ttccattcct   2520

gtgagacctc ccttccttgt ccttgtcctc tgcccttttg tgctcttctg tgatcacagg   2580

accatttcca tggaatgcag attcataccc agccagcctt tgcctctact gtatcgcttt   2640

gggactttaa agatgcagaa gtattagaac acacacaaac ttaaaatgga aagttaccaa   2700

atgtagcact agaggcaaga aaaggggtga ttttttaaag atttggctat acttaagata   2760

tttaaagagg atgaggttga gtcgtgagta taatttagaa gctctccagt gagtattttt   2820

ttagtatcaa atagtgatct tcttttgcta acataaaaat gagtaaacta cagcagagaa   2880

ataagaataa aactaatgaa gggtttttta aaagaactaa ataaaacaaa taaaactagg   2940

ctacaggtat agctgaccaa gtttgctgtg aaaaatcctt gttatatcta tttctgtatt   3000

ggagtaatgt gtagattagt ggattgttag ggatttcagc agtataagaa agaatcaaat   3060

atcttgcttt tgggtcttct ccaaagtaaa ttgcatggac ttcttaaaga agtttgaaat   3120

cagtaaaaag acattaggat catgcaattt tactttgtct agcttctaat gtggtaaatt   3180

gcacattgtg caacagaacc attaataaaa gaaaggagtt agttttgagg taactgcatt   3240

cattaggggc tgaaaataaa tgttaaaaat gtttaatttg gttagaagtt ctacaacatt   3300

gtatgtacat atacaaaatt tcattttctc tgaaagtcga gaattccaag aactgttaca   3360

tataatcata tatatgccta tatctaaacg ttttccctcc tttaatattg ataaagttaa   3420

tatattttag gatgttatgt aaatattttt gcatgtatct gtagctccat cttaatcaaa   3480

tttatggtta aaagagattt gaggccaggc gtggaggctc acacctataa tcccaacact   3540

ttgggaggcc gaggtgggag gatcacttga gcacaggagt ttgagaccag cctgtgcaac   3600

atcatgaaac atcatctcta cataaaaaaa tacatatata caaaaattag ctgggcatca   3660

tggcacacac ctgtagtccc agctacttag gaggctgaga tgggaggatt gatcgatcgc   3720

ttgagcctgg gaggtggagg ctactgtgag ccatgatcat gccactgcac tccagcctgg   3780

gcaacagagt gagaccctgt ctccaaagag aaagagaaac ttgagaaggc ttgtgcccaa   3840

agcttgaaga aagattgtaa tagcatttag ttgtgtttta tcatgttatc ttcataacat   3900

gcattttgca tatggctcag agcagagccg gatctcccaa ggaagcacaa atagtttttg   3960

tcgctaactt agttatgagt gaagcctctg ttcacttata acttgccagt ttcattggtg   4020

gaataagtcc ccttactcat gattcatcaa tattcctata ttaaaattcc agtttgatgt   4080

ttgtctctag ttgtctgtgt ataatatttc caaagctcct ttgtaaaccc cgtctccttt   4140

cattcagaga gtcagagacg gtatctcctc ctcctgcctc ttctattgtt ctgattagtc   4200

tacttaaatt cacttgatgc tctttttatt ttacaagaga cttgagaaat gtcggttgtt   4260

cctaatggca aactacttta gctgggaaaa ttcatttcaa cttattttaa gcttgtaaaa   4320

tacactgtgg tgataaaata aaagagctgg gtttga                             4356


<210>  688
<211>  396
<212>  PRT
<213>  Homosapiens

<400>  688

Met Pro Pro Lys Lys Gly Gly Asp Gly Ile Lys Pro Pro Pro Ile Ile 
1               5                   10                  15      


Gly Arg Phe Gly Thr Ser Leu Lys Ile Gly Ile Val Gly Leu Pro Asn 
            20                  25                  30          


Val Gly Lys Ser Thr Phe Phe Asn Val Leu Thr Asn Ser Gln Ala Ser 
        35                  40                  45              


Ala Glu Asn Phe Pro Phe Cys Thr Ile Asp Pro Asn Glu Ser Arg Val 
    50                  55                  60                  


Pro Val Pro Asp Glu Arg Phe Asp Phe Leu Cys Gln Tyr His Lys Pro 
65                  70                  75                  80  


Ala Ser Lys Ile Pro Ala Phe Leu Asn Val Val Asp Ile Ala Gly Leu 
                85                  90                  95      


Val Lys Gly Ala His Asn Gly Gln Gly Leu Gly Asn Ala Phe Leu Ser 
            100                 105                 110         


His Ile Ser Ala Cys Asp Gly Ile Phe His Leu Thr Arg Ala Phe Glu 
        115                 120                 125             


Asp Asp Asp Ile Thr His Val Glu Gly Ser Val Asp Pro Ile Arg Asp 
    130                 135                 140                 


Ile Glu Ile Ile His Glu Glu Leu Gln Leu Lys Asp Glu Glu Met Ile 
145                 150                 155                 160 


Gly Pro Ile Ile Asp Lys Leu Glu Lys Val Ala Val Arg Gly Gly Asp 
                165                 170                 175     


Lys Lys Leu Lys Pro Glu Tyr Asp Ile Met Cys Lys Val Lys Ser Trp 
            180                 185                 190         


Val Ile Asp Gln Lys Lys Pro Val Arg Phe Tyr His Asp Trp Asn Asp 
        195                 200                 205             


Lys Glu Ile Glu Val Leu Asn Lys His Leu Phe Leu Thr Ser Lys Pro 
    210                 215                 220                 


Met Val Tyr Leu Val Asn Leu Ser Glu Lys Asp Tyr Ile Arg Lys Lys 
225                 230                 235                 240 


Asn Lys Trp Leu Ile Lys Ile Lys Glu Trp Val Asp Lys Tyr Asp Pro 
                245                 250                 255     


Gly Ala Leu Val Ile Pro Phe Ser Gly Ala Leu Glu Leu Lys Leu Gln 
            260                 265                 270         


Glu Leu Ser Ala Glu Glu Arg Gln Lys Tyr Leu Glu Ala Asn Met Thr 
        275                 280                 285             


Gln Ser Ala Leu Pro Lys Ile Ile Lys Ala Gly Phe Ala Ala Leu Gln 
    290                 295                 300                 


Leu Glu Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Arg Ala Trp Thr 
305                 310                 315                 320 


Ile Arg Lys Gly Thr Lys Ala Pro Gln Ala Ala Gly Lys Ile His Thr 
                325                 330                 335     


Asp Phe Glu Lys Gly Phe Ile Met Ala Glu Val Met Lys Tyr Glu Asp 
            340                 345                 350         


Phe Lys Glu Glu Gly Ser Glu Asn Ala Val Lys Ala Ala Gly Lys Tyr 
        355                 360                 365             


Arg Gln Gln Gly Arg Asn Tyr Ile Val Glu Asp Gly Asp Ile Ile Phe 
    370                 375                 380                 


Phe Lys Phe Asn Thr Pro Gln Gln Pro Lys Lys Lys 
385                 390                 395     


<210>  689
<211>  3128
<212>  DNA
<213>  Homosapiens

<400>  689
gtgtgctcgc gcctctcgcc cggcctctaa gagtcgttgg ggccagacgc tgcttccttg     60

cctcccgcgg aggccgccgc cgccgccgcc gccgctgccg ccgccgccgc tgccgccgcc    120

cgggcggcac tgacgccgga gtcatgcagg atgaggtcgg gggattcgga acggggcgtc    180

tccaggttgc tggcgtccgt gtcactgtcg ctgccctttt tgcccccgcc gcccccgttg    240

tgcgtcttaa tgtgtttgct caggtggtcg ctgcgcatga agcgcttgtt gcacaccgga    300

caggcgaagc gcttctcgcc cgtgtgagtc cgcagatgcc gctgcagctc gtccgagcgc    360

gtgaagcgct tgccgcagaa gagccagttg cacacgaagg gccgctcgcc cgtgtgccag    420

cgcaggtgcg ccttcaggtg cgacgtcttc ccgtacacct tgccgcagcc cggaatgtgg    480

cagctgtgca ggcccttgcg ccgcaggctc gccccggccg ggcccagccg ctccgcctcc    540

tggcagttgg ggcagtcgca ggtggcgcgg cccgagtagc ggcgggcaga gcgtgccgag    600

ctccccccgg cggcggcagc cgcggcgccc gatatcatgg cgctggcggc ggcggctgcc    660

acggcggcgc tggagtccga ataggagggc aacaccggct tgaagccgtc ctgggccagc    720

aggtgctggc tggtggagag caggtgggag gcggcggcgg cggaggagcc gaggcccgtg    780

gagctgaagg cggagtgcgt gagcgagctg aagtcggggt tgtaggtgcc cagctgcgag    840

tgcagcgagg cctggggggc gcccgagtgc agcgagctct ggagcccccc agcggggttc    900

tgcacttcca gccacgagcc cgggctgctg tgcacgtccc accacgacga cgccgcgccg    960

ttggtcacct cgccggccgc cagcgtcgaa tggaagcccg acttgtacca ggactcgtac   1020

gggtgcgcca tgcccacgcg cgggtacagc ccgtcggctg ccgtcgtgtg caccttggaa   1080

atgaaggccg actggccacc cgcctcctgc ggggacaccc cggccgctgc cgccgcggca   1140

gccgccgagt tggagaagag gccgccgtag tcgctgctga aggcggacga cgtgggcgac   1200

gtggaggcca ggcagaaggc gctgttggcg gcgcccgagc cgcccgccag gccgcccgag   1260

ccacggcccc cggtggccac cgcgaagccc gagaggctgg agccgaggtt gcagctggac   1320

gaggagcgct tccaggggtg aaagccgcct ttggcgaagg cgctcgactc tggcagcgtc   1380

gtcagcgggc tcgtgttgcc gatcttgttg caggtcgccg ccagcatggc caacggggtc   1440

gttccgaagc gcggctcttc ctagagtggg tgggatgggg gagggagcaa gaaggaggag   1500

ggcaagagga agtgggggaa gaaacaaagt gcacccgtga gcagcctcgt cccctgcggc   1560

tgctcccggg gggtcctggc tccccgcctc gcgcctcctc cccacgcgcc cgcggaggag   1620

tcgccgcacc gggcgcggag caggggcgat cacccgggcg aaggtccagg cgccggaaag   1680

ttgcacttcg ctgaggctat aaatcaaaga tgcctccgtg ttccccgctg caaccctgcc   1740

tacaaccgga cttgggttgt cgccgtaaac cggctcatct cccagaagac cccaagtcgc   1800

ccttcggggt gaagcgcgaa ggtaaacaca gagaccagag acaacaaaca ccgggtgagg   1860

gcggaggcgg ccgaaacagc agccagggac gggcgaaact tgcagctctc ccagggtggc   1920

tacgacttga cttttctttt ttaatagaaa acgtttggtt ttaaagttta catacacaca   1980

aaaacagcga ttatgaaaac aataatccga ggataagcgg ccagagacag atttcaaagt   2040

catgggcgaa ttggggagcc gcggaaatgt aaatgtttat tagcgtgact agatggactg   2100

caaaacgatt aagactgttt tctggaaaca ccattgtcgc ataattgcaa caaaatcccc   2160

aaagcaaggc gggggatggg gtataaatca cgaggggaag aaaagaaacc tctagctttt   2220

ttttgaaacc aaatgaaaaa ggacttgatt aagaaggcct tttcttgcaa aggcatcttt   2280

ctgggttcca aaaacttggg gaaaaatcag tcccagaaat gtggaaagtg ctaatagaag   2340

ctgaagctgc agtctagcag caacagtttc tccggagccg cagaccccag aagccataac   2400

gaaaaattac tccggttaaa acaagcaaat gcgttgccgc gcttgcgact taccccgagt   2460

atagacgtgg ccatagcagg tctctggctg cgcagcgagg ctgggagcgg ggctgagcct   2520

ggcggctgct cggaaaaact gcttgggtcc cgcgcggctc ccgcgtcccc gcgctcgtgc   2580

cgagcggact ccaggctccc gccggctaaa ctcagcctaa gtgcgaggag cacccgcttt   2640

gaagtgccgc tggctgcgcc tctcgcccaa tgagggcgca ggcagagcag accggagctg   2700

ccccgcagcc aatcagacgc tccgaggggc ccgagcccgg gctcccggcg cgtgccagtc   2760

aagtcagcta gctagggccg cgggggtggg ggggagtagt gggggatact tgcggtgggg   2820

gacgagggcg ggctggggac tgaagaaatt acagtgcaat taaaaattta cactcacgca   2880

ccaagccagg tttaagtacc aatgaaaccg agccacaagc acccccccac acacaaacca   2940

ccccgagatg ttgcaagtta gggctgacag tcctactcga ctccccactt gtaggaaagg   3000

aggcaggagg ggaggagaca cccagacaca gcccgcacca gcagggccca agtggagacg   3060

gaaatgtgag ccctcacttt gtgtgtccag gcttttgcct acagaacaca acttcagctt   3120

gtatctat                                                            3128


<210>  690
<211>  516
<212>  PRT
<213>  Homosapiens

<400>  690

Met Gln Asp Glu Val Gly Gly Phe Gly Thr Gly Arg Leu Gln Val Ala 
1               5                   10                  15      


Gly Val Arg Val Thr Val Ala Ala Leu Phe Ala Pro Ala Ala Pro Val 
            20                  25                  30          


Val Arg Leu Asn Val Phe Ala Gln Val Val Ala Ala His Glu Ala Leu 
        35                  40                  45              


Val Ala His Arg Thr Gly Glu Ala Leu Leu Ala Arg Val Ser Pro Gln 
    50                  55                  60                  


Met Pro Leu Gln Leu Val Arg Ala Arg Glu Ala Leu Ala Ala Glu Glu 
65                  70                  75                  80  


Pro Val Ala His Glu Gly Pro Leu Ala Arg Val Pro Ala Gln Val Arg 
                85                  90                  95      


Leu Gln Val Arg Arg Leu Pro Val His Leu Ala Ala Ala Arg Asn Val 
            100                 105                 110         


Ala Ala Val Gln Ala Leu Ala Pro Gln Ala Arg Pro Gly Arg Ala Gln 
        115                 120                 125             


Pro Leu Arg Leu Leu Ala Val Gly Ala Val Ala Gly Gly Ala Ala Arg 
    130                 135                 140                 


Val Ala Ala Gly Arg Ala Cys Arg Ala Pro Pro Gly Gly Gly Ser Arg 
145                 150                 155                 160 


Gly Ala Arg Tyr His Gly Ala Gly Gly Gly Gly Cys His Gly Gly Ala 
                165                 170                 175     


Gly Val Arg Ile Gly Gly Gln His Arg Leu Glu Ala Val Leu Gly Gln 
            180                 185                 190         


Gln Val Leu Ala Gly Gly Glu Gln Val Gly Gly Gly Gly Gly Gly Gly 
        195                 200                 205             


Ala Glu Ala Arg Gly Ala Glu Gly Gly Val Arg Glu Arg Ala Glu Val 
    210                 215                 220                 


Gly Val Val Gly Ala Gln Leu Arg Val Gln Arg Gly Leu Gly Gly Ala 
225                 230                 235                 240 


Arg Val Gln Arg Ala Leu Glu Pro Pro Ser Gly Val Leu His Phe Gln 
                245                 250                 255     


Pro Arg Ala Arg Ala Ala Val His Val Pro Pro Arg Arg Arg Arg Ala 
            260                 265                 270         


Val Gly His Leu Ala Gly Arg Gln Arg Arg Met Glu Ala Arg Leu Val 
        275                 280                 285             


Pro Gly Leu Val Arg Val Arg His Ala His Ala Arg Val Gln Pro Val 
    290                 295                 300                 


Gly Cys Arg Arg Val His Leu Gly Asn Glu Gly Arg Leu Ala Thr Arg 
305                 310                 315                 320 


Leu Leu Arg Gly His Pro Gly Arg Cys Arg Arg Gly Ser Arg Arg Val 
                325                 330                 335     


Gly Glu Glu Ala Ala Val Val Ala Ala Glu Gly Gly Arg Arg Gly Arg 
            340                 345                 350         


Arg Gly Gly Gln Ala Glu Gly Ala Val Gly Gly Ala Arg Ala Ala Arg 
        355                 360                 365             


Gln Ala Ala Arg Ala Thr Ala Pro Gly Gly His Arg Glu Ala Arg Glu 
    370                 375                 380                 


Ala Gly Ala Glu Val Ala Ala Gly Arg Gly Ala Leu Pro Gly Val Lys 
385                 390                 395                 400 


Ala Ala Phe Gly Glu Gly Ala Arg Leu Trp Gln Arg Arg Gln Arg Ala 
                405                 410                 415     


Arg Val Ala Asp Leu Val Ala Gly Arg Arg Gln His Gly Gln Arg Gly 
            420                 425                 430         


Arg Ser Glu Ala Arg Leu Phe Leu Glu Trp Val Gly Trp Gly Arg Glu 
        435                 440                 445             


Gln Glu Gly Gly Gly Gln Glu Glu Val Gly Glu Glu Thr Lys Cys Thr 
    450                 455                 460                 


Arg Glu Gln Pro Arg Pro Leu Arg Leu Leu Pro Gly Gly Pro Gly Ser 
465                 470                 475                 480 


Pro Pro Arg Ala Ser Ser Pro Arg Ala Arg Gly Gly Val Ala Ala Pro 
                485                 490                 495     


Gly Ala Glu Gln Gly Arg Ser Pro Gly Arg Arg Ser Arg Arg Arg Lys 
            500                 505                 510         


Val Ala Leu Arg 
        515     


<210>  691
<211>  1809
<212>  DNA
<213>  Homosapiens

<400>  691
cttgctgctg gaaacgcagt tccggttagg cggctgagtt tgtttacgtt gctaacagat     60

ctagcccctg ctttccctag ttccagttcc aagatgggga aatccttcgc caacttcatg    120

tgcaagaaag actttcatcc tgcctccaaa tccaatatca aaaaagtatg gatggcagaa    180

cagaaaatat catatgataa gaagaaacaa gaagaattga tgcagcaata tcttaaagaa    240

caagaatcat atgataatag attgcttatg ggagatgaac gtgtaaagaa tggccttaat    300

ttcatgtatg aagccccacc aggagctaaa aaagaaaaca aagagaaaga agaaacagaa    360

ggagagaccg aatacaaatt tgaatggcag aaaggagccc cacgagaaaa atatgccaaa    420

gatgacatga acatcagaga tcagcccttt ggtattcagg ttcgaaatgt gaggtgcatt    480

aaatgtcaca aatggggtca tgtcaacaca gatcgagaat gtcctttgtt tggtctttct    540

ggaatcaatg caagttcggt tcccactgat ggctcagggc catcgatgca cccctcggag    600

ctaatagcgg agatgagaaa cagtgggttt gcactgaaac gaaatgtact ggggagaaac    660

ttgaccgcaa atgatccatc acaggagtat gttgcaagtg agggtgaaga agatccagaa    720

gttgaatttt taaagtcact aacaaccaaa caaaaacaga aacttctcag gaaattagat    780

cgactggaga agaaaaaaaa gaaaaaagat agaaaaaaga aaaagtttca gaagagcaga    840

agtaaacaca aaaaacataa gtcctcttct tcctcatctt cctcctcctc ctcctcttcc    900

tctactgaga cttcagaaag cagtagtgag agtgagagta acaataaaga aaaaaaaata    960

caaaggaaga aaagaaagaa aaacaagtgt tcagggcata acaacagtga ttctgaagag   1020

aaggacaagt ctaagaagag aaagcttcat gaagaacttt ctagcagtca ccataaccgg   1080

gaaaaagcca aggaaaagcc caggttctta aaacacgaga gttctaggga ggacagcaaa   1140

tggagccatt ctgattctga caaaaagtcc agaacccata aacatagccc agagaagaga   1200

ggctctgaaa gaaaggaggg gagcagcaga agccacggca gggaggaaag gagccggaga   1260

agccggagca gaagtcctgg tagttacaag caaagggaga caaggaaacg ggcacagcga   1320

aatcctggtg aagagcaaag cagaagaaat gacagcagaa gccatggcac agacttgtat   1380

agaggagaaa aaatgtacag agagcaccca ggaggtacac atactaaagt gacacaaaga   1440

gaatgaagca gaagtagaga agaaagactg tatgtgacaa ttacctggga ataaaaatat   1500

ctccactttt ttattgaata cctttagcaa ggggtaaatt atgtactgtt gtctttctaa   1560

taaaaaagct caattttaat ttttcatctc tagactgtca attcaagtac aaaactacat   1620

gagtactata agaatgaatt ttgcaaatat ttgtaagtaa gctattttgg ggctgtggaa   1680

atattttctg ttggtaactg tttcttgttc cccataccag ataaaaaccg catataactc   1740

tgtgacattt tctttgttct gaaacatcat taaaagaatg acagtacatt gaaaaaaaaa   1800

aaaaaaaaa                                                           1809


<210>  692
<211>  450
<212>  PRT
<213>  Homosapiens

<400>  692

Met Gly Lys Ser Phe Ala Asn Phe Met Cys Lys Lys Asp Phe His Pro 
1               5                   10                  15      


Ala Ser Lys Ser Asn Ile Lys Lys Val Trp Met Ala Glu Gln Lys Ile 
            20                  25                  30          


Ser Tyr Asp Lys Lys Lys Gln Glu Glu Leu Met Gln Gln Tyr Leu Lys 
        35                  40                  45              


Glu Gln Glu Ser Tyr Asp Asn Arg Leu Leu Met Gly Asp Glu Arg Val 
    50                  55                  60                  


Lys Asn Gly Leu Asn Phe Met Tyr Glu Ala Pro Pro Gly Ala Lys Lys 
65                  70                  75                  80  


Glu Asn Lys Glu Lys Glu Glu Thr Glu Gly Glu Thr Glu Tyr Lys Phe 
                85                  90                  95      


Glu Trp Gln Lys Gly Ala Pro Arg Glu Lys Tyr Ala Lys Asp Asp Met 
            100                 105                 110         


Asn Ile Arg Asp Gln Pro Phe Gly Ile Gln Val Arg Asn Val Arg Cys 
        115                 120                 125             


Ile Lys Cys His Lys Trp Gly His Val Asn Thr Asp Arg Glu Cys Pro 
    130                 135                 140                 


Leu Phe Gly Leu Ser Gly Ile Asn Ala Ser Ser Val Pro Thr Asp Gly 
145                 150                 155                 160 


Ser Gly Pro Ser Met His Pro Ser Glu Leu Ile Ala Glu Met Arg Asn 
                165                 170                 175     


Ser Gly Phe Ala Leu Lys Arg Asn Val Leu Gly Arg Asn Leu Thr Ala 
            180                 185                 190         


Asn Asp Pro Ser Gln Glu Tyr Val Ala Ser Glu Gly Glu Glu Asp Pro 
        195                 200                 205             


Glu Val Glu Phe Leu Lys Ser Leu Thr Thr Lys Gln Lys Gln Lys Leu 
    210                 215                 220                 


Leu Arg Lys Leu Asp Arg Leu Glu Lys Lys Lys Lys Lys Lys Asp Arg 
225                 230                 235                 240 


Lys Lys Lys Lys Phe Gln Lys Ser Arg Ser Lys His Lys Lys His Lys 
                245                 250                 255     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Glu 
            260                 265                 270         


Thr Ser Glu Ser Ser Ser Glu Ser Glu Ser Asn Asn Lys Glu Lys Lys 
        275                 280                 285             


Ile Gln Arg Lys Lys Arg Lys Lys Asn Lys Cys Ser Gly His Asn Asn 
    290                 295                 300                 


Ser Asp Ser Glu Glu Lys Asp Lys Ser Lys Lys Arg Lys Leu His Glu 
305                 310                 315                 320 


Glu Leu Ser Ser Ser His His Asn Arg Glu Lys Ala Lys Glu Lys Pro 
                325                 330                 335     


Arg Phe Leu Lys His Glu Ser Ser Arg Glu Asp Ser Lys Trp Ser His 
            340                 345                 350         


Ser Asp Ser Asp Lys Lys Ser Arg Thr His Lys His Ser Pro Glu Lys 
        355                 360                 365             


Arg Gly Ser Glu Arg Lys Glu Gly Ser Ser Arg Ser His Gly Arg Glu 
    370                 375                 380                 


Glu Arg Ser Arg Arg Ser Arg Ser Arg Ser Pro Gly Ser Tyr Lys Gln 
385                 390                 395                 400 


Arg Glu Thr Arg Lys Arg Ala Gln Arg Asn Pro Gly Glu Glu Gln Ser 
                405                 410                 415     


Arg Arg Asn Asp Ser Arg Ser His Gly Thr Asp Leu Tyr Arg Gly Glu 
            420                 425                 430         


Lys Met Tyr Arg Glu His Pro Gly Gly Thr His Thr Lys Val Thr Gln 
        435                 440                 445             


Arg Glu 
    450 


<210>  693
<211>  2497
<212>  DNA
<213>  Homosapiens

<400>  693
gacagcttcc ggcaactgat gcctccactg gccactcctc cctccgtcca cctgtcactt     60

cgggtagctg ggaggccagt taaaaaaaat ggaacctttt tcctgtgaca ctttcgtggc    120

attacctcca gcaacagtcg ataacaggat tatttttgga aaaaattcag atagactcta    180

tgatgaagta caagaggtgg tttattttcc tgctgtagtt catgataacc tgggagaacg    240

tcttaagtgt acatatatag aaattgatca agttcctgaa acatatgctg ttgtcctgag    300

tcgcccagcg tggttgtggg gggcagaaat gggagccaat gagcatggag tttgcattgg    360

gaatgaagct gtatggggaa gagaagaagt ttgtgatgaa gaagcactat taggaatgga    420

ccttgtcaga cttggccttg aaagagctga tacagctgaa aaagccctca atgtcattgt    480

tgacttacta gaaaaatatg gccagggtgg aaattgcaca gagggtagaa tggtatttag    540

ctatcacaac agtttcctga tagctgatag gaatgaagcc tggattctgg agactgcagg    600

gaagtactgg gcagcagaaa aagtacaaga gggagttcgt aatatttcta atcaactttc    660

cataacaacc aagattgccc gggaacaccc agacatgaga aactatgcta agcggaaagg    720

ttggtgggat ggtaaaaagg agtttgattt tgctgcagca tattcctatc ttgacacagc    780

caagatgatg acttcatcag gcagatactg tgagggctac aagcttctaa ataagcacaa    840

aggaaatata acttttgaaa caatgatgga aattcttcga gataaaccaa gtggcattaa    900

tatggaggga gaattcctga ccactgcaag catggtttct attttacctc aagactccag    960

ccttccttgc attcacttct ttacagggac tcctgatcct gagagatctg tttttaagcc   1020

tttcatattt gtgccacata tttcacaact attggatacc agttcaccaa catttgaact   1080

tgaagatcta gttaaaaaga aatcacattt taagcctgac agaagacacc cactctacca   1140

aaaacatcaa caggcattgg aagtagtaaa taataatgag gaaaaagcca aaataatgtt   1200

ggacaacatg aggaaactgg agaaagaact attcagagag atggaatcaa tccttcaaaa   1260

caagcatctt gatgtggaga aaattgttaa tctctttcct cagtgtacaa aagatgaaat   1320

tcaaatttat cagtcaaatt tatcagtcaa agttagttct tagtgatcat atggtcagct   1380

aatattagtt cttagtgatc agtggtcagt aatcttcaaa gtcagaatct atcaccttgg   1440

taaattatat aaacctaact tgagcagatc tgattattct tggatagtat tcaagtggta   1500

tcttgactat taaactacgt atagtgttgc tgaaatagaa agaaaacagc attggaattg   1560

gattcatgta tcgtgggata caggtgttat ttcaggtgat gtacttgcat tattttcttt   1620

agccatagta actttttgtc acaataacta agtattcaat tatatataaa gagtgaaaca   1680

ttaaaatgac gcatggattt atatttatta taattatgta gtaccctcaa atcattttgt   1740

cagttacatc aagaaagcag atttttcttt agtcatgaaa aatatctcaa gtggtaagtt   1800

gtttgtgctt taggcaaaca ttaaccagct ctaacaagaa aaatgtctag atttacacat   1860

tgtcaataca gtatattagt tctgcaaatg cacttttgtt aaactcaaac atgctctttg   1920

tcaagacttg gctaaccagt gagcttgtag ctctgattat ctagcatttt tagggtcatt   1980

ctccttaata ggcttttatg ttaataagat atatttttag aagagcttgt ttgggagatt   2040

agagaataag ataaaagaac caaaacctta ggatatactg tttctgggtc tgaaatctct   2100

ctcattgttt acttctgttc actcagtgaa aacagaaaca agaatgaggt agtggcaatg   2160

aaatagaatt attagtatat tatgaacatt ataacatttt gaacactata atgcattata   2220

tattatgaac ttttatgaac tttatacatg agtaatagct tcctaaagtt tataaaacat   2280

tgtttaggtt acataaagat taccaagtaa gactcaaaat tgcaaatata aacaaaagaa   2340

aaatccaact gaaaataaca ctaagtattt ttgagttcct agaatgtcca ttttggtatt   2400

tggttacatt atcatattta ctagtcacta tcagcacaat taggttaata aagaagtggg   2460

tcattataaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                            2497


<210>  694
<211>  424
<212>  PRT
<213>  Homosapiens

<400>  694

Met Glu Pro Phe Ser Cys Asp Thr Phe Val Ala Leu Pro Pro Ala Thr 
1               5                   10                  15      


Val Asp Asn Arg Ile Ile Phe Gly Lys Asn Ser Asp Arg Leu Tyr Asp 
            20                  25                  30          


Glu Val Gln Glu Val Val Tyr Phe Pro Ala Val Val His Asp Asn Leu 
        35                  40                  45              


Gly Glu Arg Leu Lys Cys Thr Tyr Ile Glu Ile Asp Gln Val Pro Glu 
    50                  55                  60                  


Thr Tyr Ala Val Val Leu Ser Arg Pro Ala Trp Leu Trp Gly Ala Glu 
65                  70                  75                  80  


Met Gly Ala Asn Glu His Gly Val Cys Ile Gly Asn Glu Ala Val Trp 
                85                  90                  95      


Gly Arg Glu Glu Val Cys Asp Glu Glu Ala Leu Leu Gly Met Asp Leu 
            100                 105                 110         


Val Arg Leu Gly Leu Glu Arg Ala Asp Thr Ala Glu Lys Ala Leu Asn 
        115                 120                 125             


Val Ile Val Asp Leu Leu Glu Lys Tyr Gly Gln Gly Gly Asn Cys Thr 
    130                 135                 140                 


Glu Gly Arg Met Val Phe Ser Tyr His Asn Ser Phe Leu Ile Ala Asp 
145                 150                 155                 160 


Arg Asn Glu Ala Trp Ile Leu Glu Thr Ala Gly Lys Tyr Trp Ala Ala 
                165                 170                 175     


Glu Lys Val Gln Glu Gly Val Arg Asn Ile Ser Asn Gln Leu Ser Ile 
            180                 185                 190         


Thr Thr Lys Ile Ala Arg Glu His Pro Asp Met Arg Asn Tyr Ala Lys 
        195                 200                 205             


Arg Lys Gly Trp Trp Asp Gly Lys Lys Glu Phe Asp Phe Ala Ala Ala 
    210                 215                 220                 


Tyr Ser Tyr Leu Asp Thr Ala Lys Met Met Thr Ser Ser Gly Arg Tyr 
225                 230                 235                 240 


Cys Glu Gly Tyr Lys Leu Leu Asn Lys His Lys Gly Asn Ile Thr Phe 
                245                 250                 255     


Glu Thr Met Met Glu Ile Leu Arg Asp Lys Pro Ser Gly Ile Asn Met 
            260                 265                 270         


Glu Gly Glu Phe Leu Thr Thr Ala Ser Met Val Ser Ile Leu Pro Gln 
        275                 280                 285             


Asp Ser Ser Leu Pro Cys Ile His Phe Phe Thr Gly Thr Pro Asp Pro 
    290                 295                 300                 


Glu Arg Ser Val Phe Lys Pro Phe Ile Phe Val Pro His Ile Ser Gln 
305                 310                 315                 320 


Leu Leu Asp Thr Ser Ser Pro Thr Phe Glu Leu Glu Asp Leu Val Lys 
                325                 330                 335     


Lys Lys Ser His Phe Lys Pro Asp Arg Arg His Pro Leu Tyr Gln Lys 
            340                 345                 350         


His Gln Gln Ala Leu Glu Val Val Asn Asn Asn Glu Glu Lys Ala Lys 
        355                 360                 365             


Ile Met Leu Asp Asn Met Arg Lys Leu Glu Lys Glu Leu Phe Arg Glu 
    370                 375                 380                 


Met Glu Ser Ile Leu Gln Asn Lys His Leu Asp Val Glu Lys Ile Val 
385                 390                 395                 400 


Asn Leu Phe Pro Gln Cys Thr Lys Asp Glu Ile Gln Ile Tyr Gln Ser 
                405                 410                 415     


Asn Leu Ser Val Lys Val Ser Ser 
            420                 


<210>  695
<211>  7473
<212>  DNA
<213>  Homosapiens

<400>  695
ctcgcggccg gcgaggggct gagctgacag ggccgcatcg gcttacccca ccttacttta     60

tcggaacgtg cctaagctgc tgcagctggc acccggttgc gctcggcgaa gagggctggg    120

ggcgggagat gacggtggtc ttctccctgc ttggcaccct gcgagcacca gctcccttct    180

cctcgccact ccaaggttgc agacgaagca ggtactgtcc tagatgttaa ggacacaaca    240

ttgagcaaaa acatgcatag tccctgcttc cgtgacactt gagtgaactg aatgtgcaaa    300

gtccctgtgg cacaaagtcc ctggggccag tgtgtgtggc gggtgtagaa ggagctaaag    360

agatctggtt ggagttggag ggtgagagaa aatgaattct aatttacctg cagagaactt    420

aaccattgca gtcaatatga ccaagacttt gcctacagca gtaacgcatg gatttaattc    480

cactaatgac ccaccttcaa tgtcaattac aaggcttttt ccagccttac tggaatgctt    540

tggcattgtc ctttgtggct acatagcagg aagggccaat gtcataacat caacccaggc    600

caaaggacta ggaaattttg tctccagatt tgcacttcca gctttattat tcaaaaacat    660

ggttgtactt aatttttcca atgtggactg gtccttccta tatagtatct taattgccaa    720

agcttctgta tttttcattg tatgtgtatt aaccttattg gttgccagtc ctgatagtcg    780

atttagcaaa gctggactat tccctatttt tgctacacaa agtaatgact ttgcattggg    840

ataccctata gttgaagctt tatatcaaac tacataccca gaatatctcc agtacattta    900

tttggtggca ccaatatctc ttatgatgtt aaaccctata gggtttattt tctgtgaaat    960

ccaaaagtgg aaagacactc aaaatgcttc tcaaaataaa ataaaaattg tgggactcgg   1020

actcctgcgt gtattacaga acccaatagt atttatggtc ttcattggca tcgccttcaa   1080

ttttattctt gatcgaaagg tacctgtata tgtcgaaaat tttcttgatg gacttggaaa   1140

ttctttttct ggatcagccc tattttatct tggtctcacg atggtgggaa aaataaagag   1200

actgaagaag tcggcatttg tagtactaat tcttctcatc acagctaaac ttctggtgct   1260

gccacttctg tgcagagaaa tggtggaact cttggacaag ggcgacagtg tggtgaacca   1320

tacaagttta tcaaattatg catttctgta tggtgtattt cctgtagcac caggagtggc   1380

tatctttgca acacaattca acatggaagt agaaattata acctcaggga tggtgataag   1440

cacatttgtg tctgctccca tcatgtacgt ttctgcctgg ttactgacct ttcccactat   1500

ggaccctaag ccattggcat atgccatcca gaatgttagt tttgatataa gtattgtcag   1560

cctgatctcc ttgatctggt ctctggctat tcttcttttg agtaagaaat ataaacagct   1620

tcctcatatg cttacaacta atttactcat tgctcagtct attgtctgtg ctggaatgat   1680

gatatggaat tttgttaaag aaaaaaattt tgttggacaa attttggtgt ttgttctatt   1740

gtacagctcc ctctatagca cctacctgtg gacaggcctt ctagcaattt ctttgtttct   1800

tttgaaaaag cgagagaggg tacaaattcc tgttggaata atcataatat ctggctgggg   1860

aattcctgct ctccttgttg gtgttctttt gataactgga aaacacaatg gagatagcat   1920

tgactcagcc ttcttttatg gaaaagaaca gatgatcacc acagcagtca ccctgttctg   1980

cagcatcctg atagctggca tatccctcat gtgcatgaac cagactgccc aagcaggaag   2040

ctatgaaggt ttcgatcagt ctcagagcca caaagtggtg gagcctggaa atactgcttt   2100

tgaggagagt ccagcaccag taaatgaacc agaacttttt acaagctcta ttccagaaac   2160

aagttgctgc tcctgctcca tgggaaatgg tgaattacac tgcccatcaa tagagccaat   2220

agcaaacaca agcaccagtg agcctgtgat tccttcgttt gagaaaaaca atcattgtgt   2280

gagtcgctgt aactcccaga gctgcatatt agcccaggaa gaagaacagt atctacagag   2340

tggagaccag caactgaccc gacatgtgtt gctgtgttta cttctcatca ttggcctgtt   2400

cgctaatctt tccagttgtt tatggtggct attcaaccaa gagcctggaa gactttatgt   2460

tgagttacag tttttctgtg ccgtgtttaa ctttggtcag ggatttattt cctttggaat   2520

ctttggatta gataaacatt taatcatcct gcctttcaaa agaagacttg aattcctatg   2580

gaacaataaa gacacagcag aaaacaggga ttctcctgtt tcagaggaaa taaaaatgac   2640

ctgtcaacaa tttatccatt atcaccgtga cctctgtatc cgaaacattg tcaaagaaag   2700

aaggtgtggt gcaaagactt ctgctggaac tttctgtggc tgtgacctgg tgagctggct   2760

aattgaagtc ggccttgcct ccgaccgtgg tgaagctgtg atatacggag acaggctggt   2820

acaaggggga gtcatccaac atattaccaa cgagtatgaa ttccgggatg agtacttgtt   2880

ttacagattt cttcaaaaga gtcctgaaca gagtcctcct gctattaatg caaacactct   2940

ccaacaggaa agatataaag aaattgagca ttcatcccca ccctcacatt cccctaagac   3000

ctaaattatg caggggagaa ccctacatgg aatcatattc tagccgcgta ttcattagtt   3060

tttagctggg tgaccttggg caagttaaca gaggcaacct ctctgagcct cagttgtctc   3120

ttctgtaaaa tgtgaaaaga tgtgctccca ccacatgcgc agggtctgtg attttacatg   3180

tatgtaaaac acataggaag ctgacttagg aaaaagagaa aaccaaatta aagttctgat   3240

aatgaatata atatagtcat cctttagtat ccaaggggat tggttccagg actcctgaag   3300

atcccaaaat ctgaggatac tcaagtccct tatataaaat ggtgtaggcc gggcatggtg   3360

gctcacgcct gtaatcccag tactttggga ggccgagtca ggtggatcac ctgaggtcag   3420

gagttcaaga ccagcctggc caacatggcg aaaccccgtc tctactataa aatacaaaaa   3480

attagttggg tgtggtggcg ggtgcctgta atcccagcta ctcaggaggc tgaggcagga   3540

gaatcgcttg aatctgggag gcagaggttg ctgtgagccg agatcgtgcc actgcactcc   3600

agcctgagca acagagcaag actctatctc aaaaataaaa taaaataaaa taaaataatt   3660

aataaaatgg tgtagtattt gcatataacc tatgcacatt ctcccatata gtttaatcat   3720

ctttagatac ttataatgcc taatacaatg taaatgctat gtaaatagtt gttgttatac   3780

tgtattgttt agggaataac aataagaaaa acagtctgta catgttcact acagatgcaa   3840

ccattgttaa gcctgactac atctttttat ctgcggttga ttgaatctat ggatgtggaa   3900

cctgtgcata tggagggtca actgtactat aaataatacg aatatgccaa cattatataa   3960

tcattgcttt ctgcaactgt ttactataat ttcaaaatta atatcctatt aactgttcct   4020

ataaattatc aaatttggca agtgtattac tagcaggaga tggaccttaa attatgacaa   4080

ctttatattt tttgatagca tctcttgaaa aagaatttta atgattctaa taagaggttc   4140

tttttctttt ttccatttcc ttgacaaata gtactcattt aaaaactaga gggctaggct   4200

tagtggctca cgcctgtaat ctcagcactt tgggaggctg aggcgggcag atcgcttgag   4260

gtcaggagtt caagaccagc ccgggcaacg tggtgaaacc cggtctgtac taaaaaaaaa   4320

aaaaaagaaa aagaaaaaga aaaaagaata cccaggtgtg gtagtgcatg cctgtagtcc   4380

cagctacttt ggagactgag gtgggagtac cccttgagcc tgggaggcgc aggttgcagt   4440

gaaccaagat cacatcactg cacttcaacc tgggtgacag agcaagaccc tgtctcaaaa   4500

acaaaaaaca agcaaaaaaa acctagaggc actatttttt tttaaagttt gtcttttctt   4560

ttctacccaa attactaatc tatgccatta aggaaaggaa taagaacctc catatgtatt   4620

attatctcca cagtcctgca gaagtacaat ctgatcttta actttcatgc tacaaataat   4680

aatttgagta gattaatttg aattttatca acaaaattat tgccatatga tgtatcattt   4740

ctgtgtttga acaaagcatc gtaatgcagg ataacttcta ctttattccc tgtagttaaa   4800

aaaaaaaaaa ctatatagtt caagccaata tttaaaaatt ctaaacctag gctgggcatg   4860

gtgactcata cctgtaatcc cagcactttg ggaggccgag gcaggtgaat tgcttcagcc   4920

caggagttcg agaccagcct ggccaatgtg gtgaaacccc atctctacta aaaaaaaaaa   4980

aaaaaaaaaa aattagccag gtgtggtggt gtgcacctgt aatcccagct acccaggagg   5040

ctgaggcagg aaaattgctt gaaaccagga ggcagaggtt gcagtgagct gagatcgtgc   5100

cactgcactc cagcctgagt gtcagagtga gactctgtct cagaaaaaaa aaaaaaaatt   5160

ctaaagatta catttagaat ttagtctttt taaagtgtcc atgtataaaa atatataatt   5220

tttaaaatta ctaaatgttg ccttttctct tagtctaata ttttagctac taaaacaaaa   5280

tataaactgg atagcttata aacaacataa acttatttct cacagttttg gaggctgtga   5340

agtccaagat taaggcacta acagatctag tgtctggtaa ggcaaatttc tggctcatag   5400

atggtacctt cttgctgtgt ccccacatgg tagatgggaa gaactggtct cattggcccc   5460

ttataaggac attaattcca ctcaataggc tccaccctca tgatctaata acctctcaaa   5520

ggccctacct cctaatacta acacattgag gatgtgactt caactttaca tttctacagg   5580

cagagaagtg gggctgtgta aattcttccc atcagtactt gaatgttcat ttaacaaata   5640

acttatcgag catctagcat gttccagaca caatctgaac actgagcaca caacagttgg   5700

aacaaatatg attcctatcc tcatggagct tctattctcc tgtgaaaaac agatgttaaa   5760

catgattgag gattaggttt caacataaga attctaggag gacacagaca tttagaccat   5820

agcatcttca ggtaaacttt atcttcagta aattaaagag atctatttag atgacctttg   5880

agcatcttaa ttattagatg tcagtgctag tttaacttat tttaaacgtt tcagatattt   5940

atttaattat actttaagtg tctcatgtaa aaaagttatt tataaaataa tttatagggt   6000

tagagtcatt gcccttttaa tgcaacaaat aaacagtttt ttaaaaacct gcatgggggc   6060

caggcgcggt ggttcatacc tgcaatccca gcactttggg aggtcgaggc tggcggatca   6120

cgaggtcagg agatcgagac caccctgatt aatgcggtga aatcccgtct ctactaaaaa   6180

tacaaaaaat tagccagacg tggtggtggg cacctatagt cccagctact cgggaggctg   6240

aggcaggaga atggcatgaa cccggaaggc ggagcttgca gtgaaccaag atcgcgccac   6300

tgcactccag cctgggcgac agagtgagac tccatcgcaa aaaaaaaaaa aaaaaaacct   6360

gcatggaagc ctagtatatt tattaataac aaataaatta tactttagtg tactattaac   6420

ctataccaat tttaagttgt gattagggaa tggggatgtt tttaagctga attgtcttgc   6480

tgcggaactt tcctttttta ataagaccat attatgactc tgaatgctca agggtaagtc   6540

taaggcctca ttgctgttac caggagattt ttctagttac agtaataaag atgttaattc   6600

acatgcatgc agacaactga aactcaagtg gagaatttgt ttgtgaacaa gtcatactac   6660

ttctgttatt tgcatgaatg gaatctgcaa tatctttttc catgggagac cctaaaagaa   6720

aaccctggat cagaatgatc tgcagtttca gataataaag gcttttaaga gacattttta   6780

gaattaaaaa tatgctaatt ttattaaatg aaaatatttg taactgttaa ctttctcact   6840

gacaaagcaa gtttctcaat aaaataccta ttttaacttg cattactgac atcttttctt   6900

tgagtaatct gaataatgca gaagccatca tagaggtctt ttctatacat tctcaatgtt   6960

ttcttaaatg ggtttcctga gttctgttct tcatgactct gggctctgca aacagggttt   7020

cccaattacg cattctataa acacttttat gaatgagtca atatgacatt gagtcctttt   7080

catacatttc atcatttcca atatgtagag tgacagctag aaaaatgata aaattttgat   7140

taaaacctat ctctttttct tcagcatagt caattgtttt cttaactctc aatgagtaac   7200

tccatgccta gcttgtgctt agctttcaat atttttagac taagacaaag tgtatttggc   7260

attttgagaa caacaattaa tggtcagtaa atttctaaag caagaaaaat gtgaaactag   7320

tgttttatat gtttgttacg cagcagaatg cggctcttag tgtttgcccc ttcatatctc   7380

atcatgtaaa atattaaatt actttaggcc actgcacata ggtagtcctg tcatgagtga   7440

tggctggaga aaagttcagg atcataaatg tta                                7473


<210>  696
<211>  870
<212>  PRT
<213>  Homosapiens

<400>  696

Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met 
1               5                   10                  15      


Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn 
            20                  25                  30          


Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu 
        35                  40                  45              


Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val 
    50                  55                  60                  


Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser 
                85                  90                  95      


Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser 
            100                 105                 110         


Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp 
        115                 120                 125             


Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser 
    130                 135                 140                 


Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr 
145                 150                 155                 160 


Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser 
                165                 170                 175     


Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys 
            180                 185                 190         


Trp Lys Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly 
        195                 200                 205             


Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe 
    210                 215                 220                 


Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr 
225                 230                 235                 240 


Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala 
                245                 250                 255     


Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys 
            260                 265                 270         


Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu 
        275                 280                 285             


Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly 
    290                 295                 300                 


Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr 
305                 310                 315                 320 


Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe 
                325                 330                 335     


Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe 
            340                 345                 350         


Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro 
        355                 360                 365             


Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe 
    370                 375                 380                 


Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ile Trp Ser Leu Ala Ile 
385                 390                 395                 400 


Leu Leu Leu Ser Lys Lys Tyr Lys Gln Leu Pro His Met Leu Thr Thr 
                405                 410                 415     


Asn Leu Leu Ile Ala Gln Ser Ile Val Cys Ala Gly Met Met Ile Trp 
            420                 425                 430         


Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile Leu Val Phe Val 
        435                 440                 445             


Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Trp Thr Gly Leu Leu 
    450                 455                 460                 


Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg Val Gln Ile Pro 
465                 470                 475                 480 


Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro Ala Leu Leu Val 
                485                 490                 495     


Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp Ser Ile Asp Ser 
            500                 505                 510         


Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr Ala Val Thr Leu 
        515                 520                 525             


Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met Cys Met Asn Gln 
    530                 535                 540                 


Thr Ala Gln Ala Gly Ser Tyr Glu Gly Phe Asp Gln Ser Gln Ser His 
545                 550                 555                 560 


Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu Ser Pro Ala Pro 
                565                 570                 575     


Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro Glu Thr Ser Cys 
            580                 585                 590         


Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys Pro Ser Ile Glu 
        595                 600                 605             


Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile Pro Ser Phe Glu 
    610                 615                 620                 


Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln Ser Cys Ile Leu 
625                 630                 635                 640 


Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp Gln Gln Leu Thr 
                645                 650                 655     


Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly Leu Phe Ala Asn 
            660                 665                 670         


Leu Ser Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu Pro Gly Arg Leu 
        675                 680                 685             


Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn Phe Gly Gln Gly 
    690                 695                 700                 


Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His Leu Ile Ile Leu 
705                 710                 715                 720 


Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn Lys Asp Thr Ala 
                725                 730                 735     


Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys Met Thr Cys Gln 
            740                 745                 750         


Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg Asn Ile Val Lys 
        755                 760                 765             


Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr Phe Cys Gly Cys 
    770                 775                 780                 


Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala Ser Asp Arg Gly 
785                 790                 795                 800 


Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly Gly Val Ile Gln 
                805                 810                 815     


His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr Leu Phe Tyr Arg 
            820                 825                 830         


Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala Ile Asn Ala Asn 
        835                 840                 845             


Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His Ser Ser Pro Pro 
    850                 855                 860                 


Ser His Ser Pro Lys Thr 
865                 870 


<210>  697
<211>  7324
<212>  DNA
<213>  Homosapiens

<400>  697
ctcgcggccg gcgaggggct gagctgacag ggccgcatcg gcttacccca ccttacttta     60

tcggaacgtg cctaagctgc tgcagctggc acccggttgc gctcggcgaa gagggctggg    120

ggcgggagat gacggtggtc ttctccctgc ttggcaccct gcgagcacca gctcccttct    180

cctcgccact ccaaggttgc agacgaagca gagatctggt tggagttgga gggtgagaga    240

aaatgaattc taatttacct gcagagaact taaccattgc agtcaatatg accaagactt    300

tgcctacagc agtaacgcat ggatttaatt ccactaatga cccaccttca atgtcaatta    360

caaggctttt tccagcctta ctggaatgct ttggcattgt cctttgtggc tacatagcag    420

gaagggccaa tgtcataaca tcaacccagg ccaaaggact aggaaatttt gtctccagat    480

ttgcacttcc agctttatta ttcaaaaaca tggttgtact taatttttcc aatgtggact    540

ggtccttcct atatagtatc ttaattgcca aagcttctgt atttttcatt gtatgtgtat    600

taaccttatt ggttgccagt cctgatagtc gatttagcaa agctggacta ttccctattt    660

ttgctacaca aagtaatgac tttgcattgg gataccctat agttgaagct ttatatcaaa    720

ctacataccc agaatatctc cagtacattt atttggtggc accaatatct cttatgatgt    780

taaaccctat agggtttatt ttctgtgaaa tccaaaagtg gaaagacact caaaatgctt    840

ctcaaaataa aataaaaatt gtgggactcg gactcctgcg tgtattacag aacccaatag    900

tatttatggt cttcattggc atcgccttca attttattct tgatcgaaag gtacctgtat    960

atgtcgaaaa ttttcttgat ggacttggaa attctttttc tggatcagcc ctattttatc   1020

ttggtctcac gatggtggga aaaataaaga gactgaagaa gtcggcattt gtagtactaa   1080

ttcttctcat cacagctaaa cttctggtgc tgccacttct gtgcagagaa atggtggaac   1140

tcttggacaa gggcgacagt gtggtgaacc atacaagttt atcaaattat gcatttctgt   1200

atggtgtatt tcctgtagca ccaggagtgg ctatctttgc aacacaattc aacatggaag   1260

tagaaattat aacctcaggg atggtgataa gcacatttgt gtctgctccc atcatgtacg   1320

tttctgcctg gttactgacc tttcccacta tggaccctaa gccattggca tatgccatcc   1380

agaatgttag ttttgatata agtattgtca gcctgatctc cttgatctgg tctctggcta   1440

ttcttctttt gagtaagaaa tataaacagc ttcctcatat gcttacaact aatttactca   1500

ttgctcagtc tattgtctgt gctggaatga tgatatggaa ttttgttaaa gaaaaaaatt   1560

ttgttggaca aattttggtg tttgttctat tgtacagctc cctctatagc acctacctgt   1620

ggacaggcct tctagcaatt tctttgtttc ttttgaaaaa gcgagagagg gtacaaattc   1680

ctgttggaat aatcataata tctggctggg gaattcctgc tctccttgtt ggtgttcttt   1740

tgataactgg aaaacacaat ggagatagca ttgactcagc cttcttttat ggaaaagaac   1800

agatgatcac cacagcagtc accctgttct gcagcatcct gatagctggc atatccctca   1860

tgtgcatgaa ccagactgcc caagcaggaa gctatgaagg tttcgatcag tctcagagcc   1920

acaaagtggt ggagcctgga aatactgctt ttgaggagag tccagcacca gtaaatgaac   1980

cagaactttt tacaagctct attccagaaa caagttgctg ctcctgctcc atgggaaatg   2040

gtgaattaca ctgcccatca atagagccaa tagcaaacac aagcaccagt gagcctgtga   2100

ttccttcgtt tgagaaaaac aatcattgtg tgagtcgctg taactcccag agctgcatat   2160

tagcccagga agaagaacag tatctacaga gtggagacca gcaactgacc cgacatgtgt   2220

tgctgtgttt acttctcatc attggcctgt tcgctaatct ttccagttgt ttatggtggc   2280

tattcaacca agagcctgga agactttatg ttgagttaca gtttttctgt gccgtgttta   2340

actttggtca gggatttatt tcctttggaa tctttggatt agataaacat ttaatcatcc   2400

tgcctttcaa aagaagactt gaattcctat ggaacaataa agacacagca gaaaacaggg   2460

attctcctgt ttcagaggaa ataaaaatga cctgtcaaca atttatccat tatcaccgtg   2520

acctctgtat ccgaaacatt gtcaaagaaa gaaggtgtgg tgcaaagact tctgctggaa   2580

ctttctgtgg ctgtgacctg gtgagctggc taattgaagt cggccttgcc tccgaccgtg   2640

gtgaagctgt gatatacgga gacaggctgg tacaaggggg agtcatccaa catattacca   2700

acgagtatga attccgggat gagtacttgt tttacagatt tcttcaaaag agtcctgaac   2760

agagtcctcc tgctattaat gcaaacactc tccaacagga aagatataaa gaaattgagc   2820

attcatcccc accctcacat tcccctaaga cctaaattat gcaggggaga accctacatg   2880

gaatcatatt ctagccgcgt attcattagt ttttagctgg gtgaccttgg gcaagttaac   2940

agaggcaacc tctctgagcc tcagttgtct cttctgtaaa atgtgaaaag atgtgctccc   3000

accacatgcg cagggtctgt gattttacat gtatgtaaaa cacataggaa gctgacttag   3060

gaaaaagaga aaaccaaatt aaagttctga taatgaatat aatatagtca tcctttagta   3120

tccaagggga ttggttccag gactcctgaa gatcccaaaa tctgaggata ctcaagtccc   3180

ttatataaaa tggtgtaggc cgggcatggt ggctcacgcc tgtaatccca gtactttggg   3240

aggccgagtc aggtggatca cctgaggtca ggagttcaag accagcctgg ccaacatggc   3300

gaaaccccgt ctctactata aaatacaaaa aattagttgg gtgtggtggc gggtgcctgt   3360

aatcccagct actcaggagg ctgaggcagg agaatcgctt gaatctggga ggcagaggtt   3420

gctgtgagcc gagatcgtgc cactgcactc cagcctgagc aacagagcaa gactctatct   3480

caaaaataaa ataaaataaa ataaaataat taataaaatg gtgtagtatt tgcatataac   3540

ctatgcacat tctcccatat agtttaatca tctttagata cttataatgc ctaatacaat   3600

gtaaatgcta tgtaaatagt tgttgttata ctgtattgtt tagggaataa caataagaaa   3660

aacagtctgt acatgttcac tacagatgca accattgtta agcctgacta catcttttta   3720

tctgcggttg attgaatcta tggatgtgga acctgtgcat atggagggtc aactgtacta   3780

taaataatac gaatatgcca acattatata atcattgctt tctgcaactg tttactataa   3840

tttcaaaatt aatatcctat taactgttcc tataaattat caaatttggc aagtgtatta   3900

ctagcaggag atggacctta aattatgaca actttatatt ttttgatagc atctcttgaa   3960

aaagaatttt aatgattcta ataagaggtt ctttttcttt tttccatttc cttgacaaat   4020

agtactcatt taaaaactag agggctaggc ttagtggctc acgcctgtaa tctcagcact   4080

ttgggaggct gaggcgggca gatcgcttga ggtcaggagt tcaagaccag cccgggcaac   4140

gtggtgaaac ccggtctgta ctaaaaaaaa aaaaaaagaa aaagaaaaag aaaaaagaat   4200

acccaggtgt ggtagtgcat gcctgtagtc ccagctactt tggagactga ggtgggagta   4260

ccccttgagc ctgggaggcg caggttgcag tgaaccaaga tcacatcact gcacttcaac   4320

ctgggtgaca gagcaagacc ctgtctcaaa aacaaaaaac aagcaaaaaa aacctagagg   4380

cactattttt ttttaaagtt tgtcttttct tttctaccca aattactaat ctatgccatt   4440

aaggaaagga ataagaacct ccatatgtat tattatctcc acagtcctgc agaagtacaa   4500

tctgatcttt aactttcatg ctacaaataa taatttgagt agattaattt gaattttatc   4560

aacaaaatta ttgccatatg atgtatcatt tctgtgtttg aacaaagcat cgtaatgcag   4620

gataacttct actttattcc ctgtagttaa aaaaaaaaaa actatatagt tcaagccaat   4680

atttaaaaat tctaaaccta ggctgggcat ggtgactcat acctgtaatc ccagcacttt   4740

gggaggccga ggcaggtgaa ttgcttcagc ccaggagttc gagaccagcc tggccaatgt   4800

ggtgaaaccc catctctact aaaaaaaaaa aaaaaaaaaa aaattagcca ggtgtggtgg   4860

tgtgcacctg taatcccagc tacccaggag gctgaggcag gaaaattgct tgaaaccagg   4920

aggcagaggt tgcagtgagc tgagatcgtg ccactgcact ccagcctgag tgtcagagtg   4980

agactctgtc tcagaaaaaa aaaaaaaaat tctaaagatt acatttagaa tttagtcttt   5040

ttaaagtgtc catgtataaa aatatataat ttttaaaatt actaaatgtt gccttttctc   5100

ttagtctaat attttagcta ctaaaacaaa atataaactg gatagcttat aaacaacata   5160

aacttatttc tcacagtttt ggaggctgtg aagtccaaga ttaaggcact aacagatcta   5220

gtgtctggta aggcaaattt ctggctcata gatggtacct tcttgctgtg tccccacatg   5280

gtagatggga agaactggtc tcattggccc cttataagga cattaattcc actcaatagg   5340

ctccaccctc atgatctaat aacctctcaa aggccctacc tcctaatact aacacattga   5400

ggatgtgact tcaactttac atttctacag gcagagaagt ggggctgtgt aaattcttcc   5460

catcagtact tgaatgttca tttaacaaat aacttatcga gcatctagca tgttccagac   5520

acaatctgaa cactgagcac acaacagttg gaacaaatat gattcctatc ctcatggagc   5580

ttctattctc ctgtgaaaaa cagatgttaa acatgattga ggattaggtt tcaacataag   5640

aattctagga ggacacagac atttagacca tagcatcttc aggtaaactt tatcttcagt   5700

aaattaaaga gatctattta gatgaccttt gagcatctta attattagat gtcagtgcta   5760

gtttaactta ttttaaacgt ttcagatatt tatttaatta tactttaagt gtctcatgta   5820

aaaaagttat ttataaaata atttataggg ttagagtcat tgccctttta atgcaacaaa   5880

taaacagttt tttaaaaacc tgcatggggg ccaggcgcgg tggttcatac ctgcaatccc   5940

agcactttgg gaggtcgagg ctggcggatc acgaggtcag gagatcgaga ccaccctgat   6000

taatgcggtg aaatcccgtc tctactaaaa atacaaaaaa ttagccagac gtggtggtgg   6060

gcacctatag tcccagctac tcgggaggct gaggcaggag aatggcatga acccggaagg   6120

cggagcttgc agtgaaccaa gatcgcgcca ctgcactcca gcctgggcga cagagtgaga   6180

ctccatcgca aaaaaaaaaa aaaaaaaacc tgcatggaag cctagtatat ttattaataa   6240

caaataaatt atactttagt gtactattaa cctataccaa ttttaagttg tgattaggga   6300

atggggatgt ttttaagctg aattgtcttg ctgcggaact ttcctttttt aataagacca   6360

tattatgact ctgaatgctc aagggtaagt ctaaggcctc attgctgtta ccaggagatt   6420

tttctagtta cagtaataaa gatgttaatt cacatgcatg cagacaactg aaactcaagt   6480

ggagaatttg tttgtgaaca agtcatacta cttctgttat ttgcatgaat ggaatctgca   6540

atatcttttt ccatgggaga ccctaaaaga aaaccctgga tcagaatgat ctgcagtttc   6600

agataataaa ggcttttaag agacattttt agaattaaaa atatgctaat tttattaaat   6660

gaaaatattt gtaactgtta actttctcac tgacaaagca agtttctcaa taaaatacct   6720

attttaactt gcattactga catcttttct ttgagtaatc tgaataatgc agaagccatc   6780

atagaggtct tttctataca ttctcaatgt tttcttaaat gggtttcctg agttctgttc   6840

ttcatgactc tgggctctgc aaacagggtt tcccaattac gcattctata aacactttta   6900

tgaatgagtc aatatgacat tgagtccttt tcatacattt catcatttcc aatatgtaga   6960

gtgacagcta gaaaaatgat aaaattttga ttaaaaccta tctctttttc ttcagcatag   7020

tcaattgttt tcttaactct caatgagtaa ctccatgcct agcttgtgct tagctttcaa   7080

tatttttaga ctaagacaaa gtgtatttgg cattttgaga acaacaatta atggtcagta   7140

aatttctaaa gcaagaaaaa tgtgaaacta gtgttttata tgtttgttac gcagcagaat   7200

gcggctctta gtgtttgccc cttcatatct catcatgtaa aatattaaat tactttaggc   7260

cactgcacat aggtagtcct gtcatgagtg atggctggag aaaagttcag gatcataaat   7320

gtta                                                                7324


<210>  698
<211>  870
<212>  PRT
<213>  Homosapiens

<400>  698

Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met 
1               5                   10                  15      


Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn 
            20                  25                  30          


Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu 
        35                  40                  45              


Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val 
    50                  55                  60                  


Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser 
                85                  90                  95      


Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser 
            100                 105                 110         


Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp 
        115                 120                 125             


Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser 
    130                 135                 140                 


Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr 
145                 150                 155                 160 


Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser 
                165                 170                 175     


Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys 
            180                 185                 190         


Trp Lys Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly 
        195                 200                 205             


Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe 
    210                 215                 220                 


Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr 
225                 230                 235                 240 


Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala 
                245                 250                 255     


Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys 
            260                 265                 270         


Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu 
        275                 280                 285             


Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly 
    290                 295                 300                 


Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr 
305                 310                 315                 320 


Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe 
                325                 330                 335     


Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe 
            340                 345                 350         


Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro 
        355                 360                 365             


Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe 
    370                 375                 380                 


Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ile Trp Ser Leu Ala Ile 
385                 390                 395                 400 


Leu Leu Leu Ser Lys Lys Tyr Lys Gln Leu Pro His Met Leu Thr Thr 
                405                 410                 415     


Asn Leu Leu Ile Ala Gln Ser Ile Val Cys Ala Gly Met Met Ile Trp 
            420                 425                 430         


Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile Leu Val Phe Val 
        435                 440                 445             


Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Trp Thr Gly Leu Leu 
    450                 455                 460                 


Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg Val Gln Ile Pro 
465                 470                 475                 480 


Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro Ala Leu Leu Val 
                485                 490                 495     


Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp Ser Ile Asp Ser 
            500                 505                 510         


Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr Ala Val Thr Leu 
        515                 520                 525             


Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met Cys Met Asn Gln 
    530                 535                 540                 


Thr Ala Gln Ala Gly Ser Tyr Glu Gly Phe Asp Gln Ser Gln Ser His 
545                 550                 555                 560 


Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu Ser Pro Ala Pro 
                565                 570                 575     


Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro Glu Thr Ser Cys 
            580                 585                 590         


Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys Pro Ser Ile Glu 
        595                 600                 605             


Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile Pro Ser Phe Glu 
    610                 615                 620                 


Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln Ser Cys Ile Leu 
625                 630                 635                 640 


Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp Gln Gln Leu Thr 
                645                 650                 655     


Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly Leu Phe Ala Asn 
            660                 665                 670         


Leu Ser Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu Pro Gly Arg Leu 
        675                 680                 685             


Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn Phe Gly Gln Gly 
    690                 695                 700                 


Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His Leu Ile Ile Leu 
705                 710                 715                 720 


Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn Lys Asp Thr Ala 
                725                 730                 735     


Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys Met Thr Cys Gln 
            740                 745                 750         


Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg Asn Ile Val Lys 
        755                 760                 765             


Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr Phe Cys Gly Cys 
    770                 775                 780                 


Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala Ser Asp Arg Gly 
785                 790                 795                 800 


Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly Gly Val Ile Gln 
                805                 810                 815     


His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr Leu Phe Tyr Arg 
            820                 825                 830         


Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala Ile Asn Ala Asn 
        835                 840                 845             


Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His Ser Ser Pro Pro 
    850                 855                 860                 


Ser His Ser Pro Lys Thr 
865                 870 


<210>  699
<211>  4605
<212>  DNA
<213>  Homosapiens

<400>  699
tagaagacag caggggaact cgagaagttg gttgttttca gcagattaaa acaatacaga     60

tttatcagca agactgttga acgcataact gcccaagatg cctgtccctc cccctccagc    120

acccccgccg cccccgacgt ttgcactggc caatacagag aagcctacct tgaataagac    180

agagcaggct gggagaaatg ctctcctttc tgatatcagc aaagggaaga aactaaagaa    240

gacggtcacc aatgacagaa gtgcaccaat actggacaaa cctaaaggag ctggtgctgg    300

aggcggtggt ggtggctttg gtggaggcgg cggatttggc ggaggaggtg gtggcggagg    360

cggtggaagt tttggagggg gcggacctcc aggtctggga ggattgttcc aggctggaat    420

gccgaagctg agatccacgg ccaacaggga taatgattct ggaggaagcc gaccaccatt    480

gttgccaccg ggaggaagat ccacatctgc gaaacccttt tcacccccaa gtggcccagg    540

gaggtttcct gtgccttctc caggccacag aagtggtccc ccagagcctc agaggaaccg    600

aatgccgccc ccaaggcccg acgtgggctc aaagcctgat agcattcctc ctccagtacc    660

tagtactcca agacccattc aatcaagtcc gcacaaccgg gggtccccac cagtgcccgg    720

aggccccagg cagcccagcc ccgggcccac tcctccccct ttccctggaa accgcggcac    780

tgctttggga ggaggctcaa tacgtcagtc ccccttgagc tcctcctcgc ccttctccaa    840

ccggcctccc ctgccgccta cccccagcag ggccttggat gacaaacccc ctccaccacc    900

tcctccagtg ggcaacaggc cctccatcca cagggaagcg gttccccctc ctcctcctca    960

gaacaacaag cctccagtgc cttccactcc gcggccttcg gcctcctcac aggccccacc   1020

tccgccgcca cctcccagca ggcccgggcc gcctcctctg cctccaagtt ccagcggcaa   1080

tgacgaaacc ccaagactcc cacagcggaa tctgtccctc agttcgtcca cgcccccgtt   1140

accttcgcca ggacgttcag gtcctcttcc tcccccgccc agtgagagac ccccacctcc   1200

agtgagggac ccgccaggcc gatcaggccc cctcccacca cctcctccag taagcagaaa   1260

cggcagcaca tctcgggccc tgcctgctac ccctcagttg ccatccagga gtggagtaga   1320

cagtcccagg agtggaccca ggcctcccct tcctcctgat aggcccagtg ctggggcacc   1380

tcccccacct ccaccatcaa catctattag aaatggcttc caagactctc catgtgaaga   1440

tgagtgggaa agcagattct acttccatcc gatttccgat ttgccacctc cagagccata   1500

tgtacaaacg accaaaagtt atcccagcaa actggcaaga aacgaaagcc ggagtggatc   1560

caaccgaaga gaaaggggtg ctccaccact ccctcccatc ccgaggtgat ctttgcctgc   1620

tcttctctac ccaagctcaa gagctgcttc tgttgctatc taagaactgc ataccctcct   1680

ccctgcttct tcccttgtgc ctcatgtatg ggcaggagga aaggtgggag ggggagtggg   1740

aatatgcgtg tgtgggtggg aatcggtaag aaatgcacct agcttttcat attgtgttta   1800

ttctccaggc tattgcttgc ttcagctgca gcctgcctgt gctggctgct ggggtcgata   1860

ggcttttgtc gtaataggca gagatgactt gcatcccagc tttccaccaa ccaaattcaa   1920

acattcactg cttatttgtt acagactgta attattaaag tccctgagag ctgttttctc   1980

ccgttccttt ttcgcatgct tggcctcctc tctgtttcta tgaaccacag accacctaag   2040

caagctgctg agtaagggct cactggaaac ttgcagtcac aggatgtcca atctttggca   2100

gtccgagctt ggctctagga cagagctgtc caatagaaat ataatgtgag ccccatatac   2160

aatttttaca tttctaatat attttaaaca agtgaagtta atatgcatcc aaaatatttc   2220

aacctgtaat caacataaaa ttttaatgag atattttata ttattttttg gtactgaatc   2280

ttcaaaatcc agagtgtatt ttacacttac cgcacatctc cattcagact agtcacattt   2340

ttaagtgctc agtagccaca tgtggctggt ggctactgga ttagacagca cgagtctgga   2400

agatggaagc tagtgcagaa acctcttgtt taaaaaacaa aaaaggcaag atgggcttga   2460

gcgattcaag aggcaactaa aaataaaatt aggacccagc accttgtttg acacacagtt   2520

tgaccttcga ttttcctccc ttaacttccc tcttccctta atatctgtat acaagtgttg   2580

cttcaaagta ccaaggtcag aaattgattc agtacggttt actaaagtca tgtggaataa   2640

agccattgga aacaaatgga aagcctgtcg ggacttctgg gctcagaacc agctggctca   2700

cgcactccac ttgtcagctg gacttctgcc ttgtgaaatg gaagcagcct ttgttccttt   2760

ctggctgagc aagctcctga ggctgggaga gactaggaag gcttggtagg aggggaaaaa   2820

agtcaggaaa agatatcaaa tcagaaacat ggaagaagaa gggaaccgat ttgagttggt   2880

gggcaaaact ctaaaaatct aaatctgatg cttatgtaag ggttgagcga attagggaga   2940

ttgctagtgg aaattggagg gaatttgttt tgcatcattt gtctaggatc tatgcaaata   3000

tagctccact aaaggaccat agggaagagc cagccttgcc ttttcttata tgattttgtt   3060

tacaaaattt tactgggact tttaaatcta gctatagagt tgggaaaaaa tatttccact   3120

tagatatttt acatggtttt gtttaaaatt accattactt gttttttaaa aacacatgac   3180

cacatatgta tatgtatatc tacctaaaca ttgtatcatg gtttcagtat gttattcatg   3240

tattactggg agatgctacc aagaaaccaa cccaaagaaa attctgaaaa atacatttct   3300

atttatagaa taaatgtttc atttatataa aagcaaaaga acttagagtt ctaataaatg   3360

ggatgtctaa taaattatga agttactgat ttgaatatat tatattttta taacttcctt   3420

gccaaagtcc tgatttagta cattagagaa cctgtgtttc ctctctcctc taccattcat   3480

ctctcttcca tacagtcatt tgggcttttt actcaaagag aatcaagaaa taataaggta   3540

taacaagctt ggcaaagtgt tggcttttta aaaaaaaatt tttttaatct ctagcagttt   3600

ggtaatttag cagcatcatt tatttgggat tcttttatct gatttcaaca gtgaaaaaca   3660

tccctatgat aaagcctaat gacccatttc acaaaagatg gaatttgccc ttcctagaaa   3720

atatgacgga gaaaagtctg actcagagaa agtgagtctg aattttataa ggggtagtaa   3780

gaattggaca attcctttgc atatctgaac ttggcaggta ccgttctaaa tctgaaacag   3840

ggtgatagct caaagttgcc attcatccag aatagattgt tttagaatgt agtgtttaag   3900

tgactgtttc attaatacac ctacaccctt tctttgaaag tttgcaacct aattgcatct   3960

aaaactatga ataagttctg tggtaaaatc ttaaactatg gaaaattaca aaaatgaatt   4020

tttcttccct gaaatcagag cttacatgtg tgttttttta taacattttc agataaatgt   4080

attcaacatg taatacagta ttttaacatt cacctcttat tttatattga aatgtattac   4140

agtattaaaa ctcagtgttc agtatttatt tcactatgca ttttatttag taaaagccag   4200

gagaaatgtt taatccaatg gtgccttact ttgtgattta aaagaaatca actttttttt   4260

atgtctaagt agtagattat ttgcatattt gtaaaaactg ttaggtcttt atattttaaa   4320

gtgtaatacc agttttgtta ttttagtagc agaaatggga tgattgttaa agttccccaa   4380

aaatgttggc atgaaattaa tttttccctc cttatagtca aggaccgtag aggaagaaaa   4440

actttttttt cataccatgc actatgtaaa cagacacatt ttgctatctg tgtcatcagg   4500

atagtgtaag tggtagggta gagactaccc tagacatctg catctttgta agttagccag   4560

acaataaaga aaagcagaat gaaaaaaaaa aaaaaaaaaa aaaaa                   4605


<210>  700
<211>  503
<212>  PRT
<213>  Homosapiens

<400>  700

Met Pro Val Pro Pro Pro Pro Ala Pro Pro Pro Pro Pro Thr Phe Ala 
1               5                   10                  15      


Leu Ala Asn Thr Glu Lys Pro Thr Leu Asn Lys Thr Glu Gln Ala Gly 
            20                  25                  30          


Arg Asn Ala Leu Leu Ser Asp Ile Ser Lys Gly Lys Lys Leu Lys Lys 
        35                  40                  45              


Thr Val Thr Asn Asp Arg Ser Ala Pro Ile Leu Asp Lys Pro Lys Gly 
    50                  55                  60                  


Ala Gly Ala Gly Gly Gly Gly Gly Gly Phe Gly Gly Gly Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Phe Gly Gly Gly Gly 
                85                  90                  95      


Pro Pro Gly Leu Gly Gly Leu Phe Gln Ala Gly Met Pro Lys Leu Arg 
            100                 105                 110         


Ser Thr Ala Asn Arg Asp Asn Asp Ser Gly Gly Ser Arg Pro Pro Leu 
        115                 120                 125             


Leu Pro Pro Gly Gly Arg Ser Thr Ser Ala Lys Pro Phe Ser Pro Pro 
    130                 135                 140                 


Ser Gly Pro Gly Arg Phe Pro Val Pro Ser Pro Gly His Arg Ser Gly 
145                 150                 155                 160 


Pro Pro Glu Pro Gln Arg Asn Arg Met Pro Pro Pro Arg Pro Asp Val 
                165                 170                 175     


Gly Ser Lys Pro Asp Ser Ile Pro Pro Pro Val Pro Ser Thr Pro Arg 
            180                 185                 190         


Pro Ile Gln Ser Ser Pro His Asn Arg Gly Ser Pro Pro Val Pro Gly 
        195                 200                 205             


Gly Pro Arg Gln Pro Ser Pro Gly Pro Thr Pro Pro Pro Phe Pro Gly 
    210                 215                 220                 


Asn Arg Gly Thr Ala Leu Gly Gly Gly Ser Ile Arg Gln Ser Pro Leu 
225                 230                 235                 240 


Ser Ser Ser Ser Pro Phe Ser Asn Arg Pro Pro Leu Pro Pro Thr Pro 
                245                 250                 255     


Ser Arg Ala Leu Asp Asp Lys Pro Pro Pro Pro Pro Pro Pro Val Gly 
            260                 265                 270         


Asn Arg Pro Ser Ile His Arg Glu Ala Val Pro Pro Pro Pro Pro Gln 
        275                 280                 285             


Asn Asn Lys Pro Pro Val Pro Ser Thr Pro Arg Pro Ser Ala Ser Ser 
    290                 295                 300                 


Gln Ala Pro Pro Pro Pro Pro Pro Pro Ser Arg Pro Gly Pro Pro Pro 
305                 310                 315                 320 


Leu Pro Pro Ser Ser Ser Gly Asn Asp Glu Thr Pro Arg Leu Pro Gln 
                325                 330                 335     


Arg Asn Leu Ser Leu Ser Ser Ser Thr Pro Pro Leu Pro Ser Pro Gly 
            340                 345                 350         


Arg Ser Gly Pro Leu Pro Pro Pro Pro Ser Glu Arg Pro Pro Pro Pro 
        355                 360                 365             


Val Arg Asp Pro Pro Gly Arg Ser Gly Pro Leu Pro Pro Pro Pro Pro 
    370                 375                 380                 


Val Ser Arg Asn Gly Ser Thr Ser Arg Ala Leu Pro Ala Thr Pro Gln 
385                 390                 395                 400 


Leu Pro Ser Arg Ser Gly Val Asp Ser Pro Arg Ser Gly Pro Arg Pro 
                405                 410                 415     


Pro Leu Pro Pro Asp Arg Pro Ser Ala Gly Ala Pro Pro Pro Pro Pro 
            420                 425                 430         


Pro Ser Thr Ser Ile Arg Asn Gly Phe Gln Asp Ser Pro Cys Glu Asp 
        435                 440                 445             


Glu Trp Glu Ser Arg Phe Tyr Phe His Pro Ile Ser Asp Leu Pro Pro 
    450                 455                 460                 


Pro Glu Pro Tyr Val Gln Thr Thr Lys Ser Tyr Pro Ser Lys Leu Ala 
465                 470                 475                 480 


Arg Asn Glu Ser Arg Ser Gly Ser Asn Arg Arg Glu Arg Gly Ala Pro 
                485                 490                 495     


Pro Leu Pro Pro Ile Pro Arg 
            500             


<210>  701
<211>  4700
<212>  DNA
<213>  Homosapiens

<400>  701
ggccgcgggt cccggcggcg gggtgggcgg gggaggcagc gggtgacaga tgtactcctc     60

tgacagctct cagtatcagc ccagtggctc cctgccattg gctcagtgca atggaccggc    120

aacgccgctc actataataa cactcatgcc tgccagcagc agcaactccg agtgcaggcg    180

ccgagcgcgg gggatgctgc cgccgccgcc gcttctgctg ccgcgcgggc ggctcccgca    240

gccccgctcc gcccggccac cgcgcgggca ctgactcccg ctcggttccg tttcgccggc    300

ccggccccct cctaggctgg aatcctcccg cggggctcgt cgtcccgacg cgaatctgag    360

gagaaacagg agcgagagac tgaggggaga gcgcggcgag catgcggagg cgggggagcc    420

tcggcgctca ccacagaggg gtgcagtgag ccagtctcca gaggacgtgc cgggggtggc    480

tgcgtgccct cgtggcgggt tcccagccca ccgtcgccgg ccccggcgcg ctgcggctgt    540

gggcgcgggg tgcgtggaag cggcggctgc ggcggaggag gcggcggctg ccccatggag    600

tgttactaca ttgtcatcag ctccacgcat ctcagcaacg gacactttcg caacatcaag    660

ggagttttcc ggggccctct cagcaagaac gggaacaaaa ctctggacta tgctgagaag    720

gaaaatacca tagcaaaagc tctggaagat ctgaaggcaa atttttactg tgaactctgt    780

gacaagcagt actataagca ccaggagttt gacaatcaca ttaattcata tgaccatgct    840

cacaagcaga ggctcaagga actgaaacaa agggaatttg ctcgaaatgt agcatctaaa    900

tccaggaaag atgaaagaaa acaggaaaag gcactccaac gcctgcacaa gctggctgag    960

ctaagaaagg aaactgtatg tgctcctgga agtggcccca tgttcaaatc aacaactgtt   1020

actgtgagag aaaactgtaa tgaaatttcc caacgagttg ttgtggattc agttaataac   1080

cagcaagatt tcaaatatac tttgattcat agtgaagaga atactaaaga tgctaccact   1140

gttgctgaag atccagaaag tgcaaataat tatacagcaa aaaataacca agttggggat   1200

caagcccagg ggattcacag acacaaaatc ggcttttctt ttgcatttcc aaagaaagcg   1260

tccgtgaagc tagagtcctc agctgcagcc ttctctgaat acagtgatga tgcctcagtg   1320

ggaaaaggat ttagcagaaa aagtagattt gtccccagtg cttgtcatct tcaacaatct   1380

tcaccaacag atgtgctttt gagttctgag gagaaaacta actcttttca tccaccagag   1440

gcaatgtgca gagacaaaga aactgttcaa actcaagaga taaaagaagt ctctagtgaa   1500

aaagatgcat tattattacc ttcattttgc aagtttcaac ttcagttatc ttctgatgca   1560

gataattgtc aaaattcagt cccattagca gatcaaatac cactagagag tgttgttatt   1620

aatgaagaca tacctgttag tggtaacagt tttgagttgt taggaaataa atccacagtt   1680

cttgacatgt ctaatgattg catatctgtg caagctacca cagaggaaaa tgttaagcat   1740

aacgaggcat ccacaactga ggttgaaaat aaaaatggtc ccgagacatt ggccccttca   1800

aatactgaag aggttaacat aactatacat aagaaaacaa atttctgcaa aagacaatgt   1860

gagccatttg tacctgtcct taacaaacac agatctacag ttcttcagtg gccatcagaa   1920

atgctggttt atacaactac gaaaccatca atttcctata gctgtaatcc tctatgtttt   1980

gacttcaagt ctactaaagt aaataataat ctagataaaa ataagccaga cttaaaagat   2040

ctttgttctc agcagaagca ggaagacatt tgcatgggac cactttcaga ttacaaggat   2100

gtatctacag aaggactcac tgattatgaa attggaagta gcaaaaataa atgcagccaa   2160

gtcactcctc ttttggctga tgatattctc tccagtagtt gtgattctgg aaaaaatgag   2220

aacacaggtc agaggtataa aaacatttcc tgtaagatca gagaaacaga aaagtataat   2280

tttactaaaa gtcaaataaa acaggacact ctagatgaaa aatacaacaa aataaggttg   2340

aaagagaccc atgaatactg gttccataaa agtagaagaa agaaaaaaag aaaaaagtta   2400

tgtcagcatc atcatatgga gaaaaccaaa gaatcagaaa ctcgctgcaa aatggaagca   2460

gagaatagtt acactgaaaa tgctgggaaa tatctattgg aaccaatttc agaaaagcag   2520

tatttagctg cagagcaatt attagactca catcagttac ttgataaaag gcccaaatca   2580

gaatccatat ccttaagtga caatgaagaa atgtgtaaaa catggaatac tgaatacaac   2640

acttatgata ctatcagttc taaaaaccac tgtaaaaaga acacaatact tttaaatgga   2700

caatcaaatg caacaatgat acattctggg aaacataatt taacatattc tagaacttac   2760

tgttgttgga aaaccaaaat gtcaagctgt agtcaggatc acagaagctt agttcttcaa   2820

aatgatatga aacacatgag tcagaatcag gctgttaaaa gaggttacaa ttctgtcatg   2880

aatgaatcag aaagattcta tcgaaaacgt agacaacatt cacattctta ttcttcagat   2940

gaaagtttaa atcgacagaa tcatttacca gaagaatttt tgaggccacc aagtacttca   3000

gttgctccct gcaagcctaa aaagaaacgg aggcgaaaaa gaggcagatt ccaccccgga   3060

tttgaaactt tagaactcaa agaaaataca gattatcccg tgaaagacaa ttcttcctta   3120

aatcctctgg ataggttaat aagtgaagac aaaaaagaga aaatgaaacc acaagaagtt   3180

gcaaaaatcg aaaggaactc agaacaaaca aaccaattaa gaaacaaact gtctttccac   3240

cctaacaatc tccttccttc tgaaaccaat ggtgaaactg agcatttaga aatggagacc   3300

acttctggtg aattgtcaga tgtttccaat gatcccacca catctgtctg tgtagctagt   3360

gccccaacaa aagaagcaat tgacaatacc ctgcttgaac acaaagaaag aagtgagaat   3420

ataaatctta atgaaaagca aattcctttt caggtgccta atattgaaag gaactttaga   3480

cagtcacagc ctaaatccta tctttgccat tatgaactgg ctgaggccct tccacaagga   3540

aagatgaatg agacaccaac tgagtggctg cgttataatt caggaatcct taacacacaa   3600

ccaccattac cattcaaaga agcacatgtc agtggtcata cttttgtaac agctgagcaa   3660

atcctggctc cattagcttt accagagcaa gcattattga tcccactaga aaaccatgac   3720

aaattcaaaa atgtaccatg tgaggtctac cagcacattc tgcagccaaa catgctggcc   3780

aacaaggtta aatttacctt tcctccagct gccctcccac cccctagcac acctctgcag   3840

cctttgcctt tgcagcagtc cttatgttct acctctgtaa ccactatcca tcacactgtt   3900

ttgcagcagc acgctgcagc tgctgcagct gcagctgcag ccgcagctgc aggaaccttt   3960

aaagtgcttc agccacacca acagtttctt tcccaaatcc cagctctcac cagaacctca   4020

ttacctcagc tctcagtagg accagtagga ccgaggcttt gtcctgggaa ccagccaact   4080

tttgttgctc ctcctcagat gccaatcatt ccagcttccg ttcttcatcc tagccatctg   4140

gctttcccat ctttacccca tgcactcttt ccttcactgc tttccccaca ccctactgtc   4200

atccctttgc aacctctctt ctagtcatca ccataatggg aaaaaaatac tcttgtgaaa   4260

actattgcta tatgcgttaa gtgttcatct atgtgggtac atggctattt aactggtgga   4320

aataaactgg ccgatacatg gcgtcattgg tttgaaatca tttactgtaa gtgcaatgat   4380

gcaaataaat ccctaagttt ctgatatata atattattaa agcactgaat agtttgaaaa   4440

tcaatacaat atatgctata tattaaaatg atgtcttaag agtatgtata atgtacataa   4500

aatatattta tagtactcta atttatgttg taaagtatgc tcccttggtt tttcttaatc   4560

tttgtgtatt tgcacctatt taatgtttag acaaagctga tggcactatg ttttgtatca   4620

tgttccttga aactgtaaat tcagtgaaaa atatctcttg caataaattt ttgttaacta   4680

tttaaaaaaa aaaaaaaaaa                                               4700


<210>  702
<211>  1209
<212>  PRT
<213>  Homosapiens

<400>  702

Met Glu Cys Tyr Tyr Ile Val Ile Ser Ser Thr His Leu Ser Asn Gly 
1               5                   10                  15      


His Phe Arg Asn Ile Lys Gly Val Phe Arg Gly Pro Leu Ser Lys Asn 
            20                  25                  30          


Gly Asn Lys Thr Leu Asp Tyr Ala Glu Lys Glu Asn Thr Ile Ala Lys 
        35                  40                  45              


Ala Leu Glu Asp Leu Lys Ala Asn Phe Tyr Cys Glu Leu Cys Asp Lys 
    50                  55                  60                  


Gln Tyr Tyr Lys His Gln Glu Phe Asp Asn His Ile Asn Ser Tyr Asp 
65                  70                  75                  80  


His Ala His Lys Gln Arg Leu Lys Glu Leu Lys Gln Arg Glu Phe Ala 
                85                  90                  95      


Arg Asn Val Ala Ser Lys Ser Arg Lys Asp Glu Arg Lys Gln Glu Lys 
            100                 105                 110         


Ala Leu Gln Arg Leu His Lys Leu Ala Glu Leu Arg Lys Glu Thr Val 
        115                 120                 125             


Cys Ala Pro Gly Ser Gly Pro Met Phe Lys Ser Thr Thr Val Thr Val 
    130                 135                 140                 


Arg Glu Asn Cys Asn Glu Ile Ser Gln Arg Val Val Val Asp Ser Val 
145                 150                 155                 160 


Asn Asn Gln Gln Asp Phe Lys Tyr Thr Leu Ile His Ser Glu Glu Asn 
                165                 170                 175     


Thr Lys Asp Ala Thr Thr Val Ala Glu Asp Pro Glu Ser Ala Asn Asn 
            180                 185                 190         


Tyr Thr Ala Lys Asn Asn Gln Val Gly Asp Gln Ala Gln Gly Ile His 
        195                 200                 205             


Arg His Lys Ile Gly Phe Ser Phe Ala Phe Pro Lys Lys Ala Ser Val 
    210                 215                 220                 


Lys Leu Glu Ser Ser Ala Ala Ala Phe Ser Glu Tyr Ser Asp Asp Ala 
225                 230                 235                 240 


Ser Val Gly Lys Gly Phe Ser Arg Lys Ser Arg Phe Val Pro Ser Ala 
                245                 250                 255     


Cys His Leu Gln Gln Ser Ser Pro Thr Asp Val Leu Leu Ser Ser Glu 
            260                 265                 270         


Glu Lys Thr Asn Ser Phe His Pro Pro Glu Ala Met Cys Arg Asp Lys 
        275                 280                 285             


Glu Thr Val Gln Thr Gln Glu Ile Lys Glu Val Ser Ser Glu Lys Asp 
    290                 295                 300                 


Ala Leu Leu Leu Pro Ser Phe Cys Lys Phe Gln Leu Gln Leu Ser Ser 
305                 310                 315                 320 


Asp Ala Asp Asn Cys Gln Asn Ser Val Pro Leu Ala Asp Gln Ile Pro 
                325                 330                 335     


Leu Glu Ser Val Val Ile Asn Glu Asp Ile Pro Val Ser Gly Asn Ser 
            340                 345                 350         


Phe Glu Leu Leu Gly Asn Lys Ser Thr Val Leu Asp Met Ser Asn Asp 
        355                 360                 365             


Cys Ile Ser Val Gln Ala Thr Thr Glu Glu Asn Val Lys His Asn Glu 
    370                 375                 380                 


Ala Ser Thr Thr Glu Val Glu Asn Lys Asn Gly Pro Glu Thr Leu Ala 
385                 390                 395                 400 


Pro Ser Asn Thr Glu Glu Val Asn Ile Thr Ile His Lys Lys Thr Asn 
                405                 410                 415     


Phe Cys Lys Arg Gln Cys Glu Pro Phe Val Pro Val Leu Asn Lys His 
            420                 425                 430         


Arg Ser Thr Val Leu Gln Trp Pro Ser Glu Met Leu Val Tyr Thr Thr 
        435                 440                 445             


Thr Lys Pro Ser Ile Ser Tyr Ser Cys Asn Pro Leu Cys Phe Asp Phe 
    450                 455                 460                 


Lys Ser Thr Lys Val Asn Asn Asn Leu Asp Lys Asn Lys Pro Asp Leu 
465                 470                 475                 480 


Lys Asp Leu Cys Ser Gln Gln Lys Gln Glu Asp Ile Cys Met Gly Pro 
                485                 490                 495     


Leu Ser Asp Tyr Lys Asp Val Ser Thr Glu Gly Leu Thr Asp Tyr Glu 
            500                 505                 510         


Ile Gly Ser Ser Lys Asn Lys Cys Ser Gln Val Thr Pro Leu Leu Ala 
        515                 520                 525             


Asp Asp Ile Leu Ser Ser Ser Cys Asp Ser Gly Lys Asn Glu Asn Thr 
    530                 535                 540                 


Gly Gln Arg Tyr Lys Asn Ile Ser Cys Lys Ile Arg Glu Thr Glu Lys 
545                 550                 555                 560 


Tyr Asn Phe Thr Lys Ser Gln Ile Lys Gln Asp Thr Leu Asp Glu Lys 
                565                 570                 575     


Tyr Asn Lys Ile Arg Leu Lys Glu Thr His Glu Tyr Trp Phe His Lys 
            580                 585                 590         


Ser Arg Arg Lys Lys Lys Arg Lys Lys Leu Cys Gln His His His Met 
        595                 600                 605             


Glu Lys Thr Lys Glu Ser Glu Thr Arg Cys Lys Met Glu Ala Glu Asn 
    610                 615                 620                 


Ser Tyr Thr Glu Asn Ala Gly Lys Tyr Leu Leu Glu Pro Ile Ser Glu 
625                 630                 635                 640 


Lys Gln Tyr Leu Ala Ala Glu Gln Leu Leu Asp Ser His Gln Leu Leu 
                645                 650                 655     


Asp Lys Arg Pro Lys Ser Glu Ser Ile Ser Leu Ser Asp Asn Glu Glu 
            660                 665                 670         


Met Cys Lys Thr Trp Asn Thr Glu Tyr Asn Thr Tyr Asp Thr Ile Ser 
        675                 680                 685             


Ser Lys Asn His Cys Lys Lys Asn Thr Ile Leu Leu Asn Gly Gln Ser 
    690                 695                 700                 


Asn Ala Thr Met Ile His Ser Gly Lys His Asn Leu Thr Tyr Ser Arg 
705                 710                 715                 720 


Thr Tyr Cys Cys Trp Lys Thr Lys Met Ser Ser Cys Ser Gln Asp His 
                725                 730                 735     


Arg Ser Leu Val Leu Gln Asn Asp Met Lys His Met Ser Gln Asn Gln 
            740                 745                 750         


Ala Val Lys Arg Gly Tyr Asn Ser Val Met Asn Glu Ser Glu Arg Phe 
        755                 760                 765             


Tyr Arg Lys Arg Arg Gln His Ser His Ser Tyr Ser Ser Asp Glu Ser 
    770                 775                 780                 


Leu Asn Arg Gln Asn His Leu Pro Glu Glu Phe Leu Arg Pro Pro Ser 
785                 790                 795                 800 


Thr Ser Val Ala Pro Cys Lys Pro Lys Lys Lys Arg Arg Arg Lys Arg 
                805                 810                 815     


Gly Arg Phe His Pro Gly Phe Glu Thr Leu Glu Leu Lys Glu Asn Thr 
            820                 825                 830         


Asp Tyr Pro Val Lys Asp Asn Ser Ser Leu Asn Pro Leu Asp Arg Leu 
        835                 840                 845             


Ile Ser Glu Asp Lys Lys Glu Lys Met Lys Pro Gln Glu Val Ala Lys 
    850                 855                 860                 


Ile Glu Arg Asn Ser Glu Gln Thr Asn Gln Leu Arg Asn Lys Leu Ser 
865                 870                 875                 880 


Phe His Pro Asn Asn Leu Leu Pro Ser Glu Thr Asn Gly Glu Thr Glu 
                885                 890                 895     


His Leu Glu Met Glu Thr Thr Ser Gly Glu Leu Ser Asp Val Ser Asn 
            900                 905                 910         


Asp Pro Thr Thr Ser Val Cys Val Ala Ser Ala Pro Thr Lys Glu Ala 
        915                 920                 925             


Ile Asp Asn Thr Leu Leu Glu His Lys Glu Arg Ser Glu Asn Ile Asn 
    930                 935                 940                 


Leu Asn Glu Lys Gln Ile Pro Phe Gln Val Pro Asn Ile Glu Arg Asn 
945                 950                 955                 960 


Phe Arg Gln Ser Gln Pro Lys Ser Tyr Leu Cys His Tyr Glu Leu Ala 
                965                 970                 975     


Glu Ala Leu Pro Gln Gly Lys Met Asn Glu Thr Pro Thr Glu Trp Leu 
            980                 985                 990         


Arg Tyr Asn Ser Gly Ile Leu Asn  Thr Gln Pro Pro Leu  Pro Phe Lys 
        995                 1000                 1005             


Glu Ala  His Val Ser Gly His  Thr Phe Val Thr Ala  Glu Gln Ile 
    1010                 1015                 1020             


Leu Ala  Pro Leu Ala Leu Pro  Glu Gln Ala Leu Leu  Ile Pro Leu 
    1025                 1030                 1035             


Glu Asn  His Asp Lys Phe Lys  Asn Val Pro Cys Glu  Val Tyr Gln 
    1040                 1045                 1050             


His Ile  Leu Gln Pro Asn Met  Leu Ala Asn Lys Val  Lys Phe Thr 
    1055                 1060                 1065             


Phe Pro  Pro Ala Ala Leu Pro  Pro Pro Ser Thr Pro  Leu Gln Pro 
    1070                 1075                 1080             


Leu Pro  Leu Gln Gln Ser Leu  Cys Ser Thr Ser Val  Thr Thr Ile 
    1085                 1090                 1095             


His His  Thr Val Leu Gln Gln  His Ala Ala Ala Ala  Ala Ala Ala 
    1100                 1105                 1110             


Ala Ala  Ala Ala Ala Ala Gly  Thr Phe Lys Val Leu  Gln Pro His 
    1115                 1120                 1125             


Gln Gln  Phe Leu Ser Gln Ile  Pro Ala Leu Thr Arg  Thr Ser Leu 
    1130                 1135                 1140             


Pro Gln  Leu Ser Val Gly Pro  Val Gly Pro Arg Leu  Cys Pro Gly 
    1145                 1150                 1155             


Asn Gln  Pro Thr Phe Val Ala  Pro Pro Gln Met Pro  Ile Ile Pro 
    1160                 1165                 1170             


Ala Ser  Val Leu His Pro Ser  His Leu Ala Phe Pro  Ser Leu Pro 
    1175                 1180                 1185             


His Ala  Leu Phe Pro Ser Leu  Leu Ser Pro His Pro  Thr Val Ile 
    1190                 1195                 1200             


Pro Leu  Gln Pro Leu Phe 
    1205                 


<210>  703
<211>  3619
<212>  DNA
<213>  Homosapiens

<400>  703
gcggccgccc ctccccgatt cccgccacct gccgcctggc caggtggaag gggcgctgcc     60

gcgagcctcc gggcctcagg gtgttccggg gagcggcgcc ccgggtctct gggcccaccc    120

gccccgggcg tcctccgaga gtgggggctg cgcccgcggg gtcagacacc tgttcggccc    180

ggcccggcgt ggtcgccggg ggccaggatg aaagtgaccg tgtgcttcgg caggacgggc    240

atcgtggtgc cctgcaagga gggccagctg cgcgtcggcg agctcaccca gcaggcgctg    300

cagcggtacc tgaagacccg ggagaagggt cctggttact gggtgaagat tcatcactta    360

gaatatacag atggaggaat cctggatcca gatgatgtct tggcagatgt tgttgaagat    420

aaagacaagg tactgattgc tgtgtttgaa gaacaagaac cactccacaa gattgagagc    480

cccagtggaa accctgcaga tcggcagagc ccagatgctt ttgagacaga agtggccgcc    540

caactggccg catttaagcc aattggtggg gagattgaag taaccccttc tgctctaaaa    600

ctaggcactc cactgctggt gaggagaagc agtgacccag tgccaggccc acctgctgat    660

acccagccaa gcgcttcaca ccctggtggc cagagtctga aactggttgt tccagattcc    720

acgcagaact tggaagacag agaagttttg aatggtgtac agacagaact actaacttcg    780

ccaagaacta aggacacatt gagtgatatg acaagaacag tggagatttc tggggaagga    840

ggcccattgg gaatacatgt agtgcccttc ttttcatctc tgagtggaag gattctagga    900

ctcttcatcc gaggcattga agacaacagc aggtccaagc gggagggact atttcacgaa    960

aatgaatgta ttgtaaaaat caacaatgtg gatctcgtag acaaaacctt tgctcaggct   1020

caagatgtct tccgccaggc aatgaaatct ccaagtgtgc tcctccacgt gcttcctcca   1080

caaaaccgtg aacagtatga aaagtcagtc attggctctc ttaacatttt tggtaataat   1140

gatggcgttt tgaaaaccaa agtgccgcct cctgtccatg gaaaatcggg actaaagaca   1200

gcaaatctca caggaaccga tagtcctgaa acagatgcat cagcttccct gcaacaaaac   1260

aagagtcccc gagtaccaag gctgggagga aaaccatcct ctccctcact ctcgcctctc   1320

atgggatttg gcagcaataa aaatgcaaag aaaattaaga ttgacctaaa gaaaggccct   1380

gaaggacttg gtttcactgt ggttaccaga gactcttcca tacatggtcc cggtcccatt   1440

tttgtaaaaa acattttacc aaagggagca gcaataaaag atggccgcct acaatcaggg   1500

gacagaattt tggaggtaaa tgggagagat gtcaccggac gaacccagga agagcttgtg   1560

gccatgctca ggagcaccaa gcagggggag acagcatcgc tggtcattgc ccgccaagaa   1620

ggacattttc tgccccgaga gttgaaagga gaacctgact gctgtgcact ctctctggag   1680

acaagcgagc agctcacctt tgagatcccc ctgaatgatt caggttctgc tggcctcggg   1740

gtgagcttaa aagggaacaa atccagagaa actggaacag acttggggat ttttatcaaa   1800

tccatcattc atggaggcgc tgcttttaag gatggtcgtc tgcgaatgaa tgaccagctg   1860

attgcagtta atggggaatc tcttttggga aagtccaacc acgaagctat ggaaacactt   1920

aggcggtcaa tgtccatgga gggaaacatc cgagggatga tccagttggt gattctgagg   1980

aggccagaga gaccaatgga ggatcctgca gagtgtgggg cattttccaa gccatgcttt   2040

gagaactgtc aaaatgctgt aaccacctct aggcgaaatg ataatagtat cctgcatcca   2100

cttggcactt gcagtccaca agacaaacag aaaggtctat tgctgcccaa tgacggatgg   2160

gccgagagtg aagttccacc ttctccaaca ccacattctg ctctgggatt gggcctcgaa   2220

gattacagcc acagctctgg ggtggattca gcagtatatt ttccagatca gcacatcaac   2280

ttcagatctg tgacaccggc caggcagcct gaatcaatta atttgaaagc ctcgaagagc   2340

atggaccttg tgccagatga aagcaaggtt cactcattgg ctggacaaaa atcggggtct   2400

gtctgataag agctctcact ctggccaagg agctctgaat tgtgagtctg cccctcaggg   2460

gaattcggag ctagaggaca tggaaaataa agccaggaaa gtcaaaaaaa cgaaagagaa   2520

ggagaagaaa aaggaaaagg gcaaattgaa agtcaaggag aaaaagcgca aagaggagaa   2580

tgaagatcca gaaaggaaaa taaagaagaa gggcttcggc gccatgctga gatttggaaa   2640

gaagaaagag gataagggtg gaaaggctga gcagaaaggt actctgaaac atggtggcct   2700

gagagaagaa gagctggaga aaatgaaaga agagcgtgaa aggattggag caaaacatca   2760

ggagctaagg gaaaagcagg caagaggtct tcttgattat gctactggtg caattggatc   2820

agtgtatgat atggatgatg atgaaatgga ccccaattat gccagagtga accactttcg   2880

ggaaccatgc acatcagcaa atgtctttag atctccatct ccccctcgag ctggaccatt   2940

tggttaccct cgggatggcc atccactgtc tccagaaaga gaccacttag agggtctcta   3000

tgccaaggtc aacaagccat accatccact ggttccagct gacagtggcc gtcctacggg   3060

tggaagcact gaccgtatcc agaagttgcg gaaagagtat tatcaggctc ggagggaagg   3120

tttcccttta tatgaagacg acgaaggaag agcaaggcca tctgagtatg acctactctg   3180

ggtgcctgga aggggtccag atgggaatgc acacaacctc cgctttgaag ggatggagag   3240

gcagtacgca tccttaccca ggggaggacc cgcagatcct gtagactatc tgccagcagc   3300

acctcggggg ctctacaagg aaagggagct tccctattat ccaggggctc atcctatgca   3360

ccctcccaaa gggagctatc cccgccccac agagctcagg gtggcagatc tccggtatcc   3420

tcagcactac ccacccccgc cagctcccca gcacaaagga ccctttcgac aagacgttcc   3480

gccttcccct ccccagcacc aaagaatgcc agcctatcag gaaacaggca gaccagggcc   3540

ccgtgggggc agcccagacc agtaccctta ccgaacccag gattcccggc agaagaaccc   3600

catgactgca gccgtatag                                                3619


<210>  704
<211>  732
<212>  PRT
<213>  Homosapiens

<400>  704

Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Gly Pro Gly Tyr Trp Val Lys Ile 
        35                  40                  45              


His His Leu Glu Tyr Thr Asp Gly Gly Ile Leu Asp Pro Asp Asp Val 
    50                  55                  60                  


Leu Ala Asp Val Val Glu Asp Lys Asp Lys Val Leu Ile Ala Val Phe 
65                  70                  75                  80  


Glu Glu Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro 
                85                  90                  95      


Ala Asp Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln 
            100                 105                 110         


Leu Ala Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser 
        115                 120                 125             


Ala Leu Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro 
    130                 135                 140                 


Val Pro Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly 
145                 150                 155                 160 


Gly Gln Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu 
                165                 170                 175     


Asp Arg Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro 
            180                 185                 190         


Arg Thr Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser 
        195                 200                 205             


Gly Glu Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser 
    210                 215                 220                 


Leu Ser Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn 
225                 230                 235                 240 


Ser Arg Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val 
                245                 250                 255     


Lys Ile Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln 
            260                 265                 270         


Asp Val Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val 
        275                 280                 285             


Leu Pro Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser 
    290                 295                 300                 


Leu Asn Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro 
305                 310                 315                 320 


Pro Pro Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly 
                325                 330                 335     


Thr Asp Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys 
            340                 345                 350         


Ser Pro Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu 
        355                 360                 365             


Ser Pro Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys 
    370                 375                 380                 


Ile Asp Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr 
385                 390                 395                 400 


Arg Asp Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile 
                405                 410                 415     


Leu Pro Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp 
            420                 425                 430         


Arg Ile Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu 
        435                 440                 445             


Glu Leu Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser 
    450                 455                 460                 


Leu Val Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Lys 
465                 470                 475                 480 


Gly Glu Pro Asp Cys Cys Ala Leu Ser Leu Glu Thr Ser Glu Gln Leu 
                485                 490                 495     


Thr Phe Glu Ile Pro Leu Asn Asp Ser Gly Ser Ala Gly Leu Gly Val 
            500                 505                 510         


Ser Leu Lys Gly Asn Lys Ser Arg Glu Thr Gly Thr Asp Leu Gly Ile 
        515                 520                 525             


Phe Ile Lys Ser Ile Ile His Gly Gly Ala Ala Phe Lys Asp Gly Arg 
    530                 535                 540                 


Leu Arg Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu Leu 
545                 550                 555                 560 


Gly Lys Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met Ser 
                565                 570                 575     


Met Glu Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg Arg 
            580                 585                 590         


Pro Glu Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser Lys 
        595                 600                 605             


Pro Cys Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg Asn 
    610                 615                 620                 


Asp Asn Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp Lys 
625                 630                 635                 640 


Gln Lys Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu Val 
                645                 650                 655     


Pro Pro Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu Asp 
            660                 665                 670         


Tyr Ser His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp Gln 
        675                 680                 685             


His Ile Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser Ile 
    690                 695                 700                 


Asn Leu Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser Lys 
705                 710                 715                 720 


Val His Ser Leu Ala Gly Gln Lys Ser Gly Ser Val 
                725                 730         


<210>  705
<211>  3642
<212>  DNA
<213>  Homosapiens

<400>  705
gcggccgccc ctccccgatt cccgccacct gccgcctggc caggtggaag gggcgctgcc     60

gcgagcctcc gggcctcagg gtgttccggg gagcggcgcc ccgggtctct gggcccaccc    120

gccccgggcg tcctccgaga gtgggggctg cgcccgcggg gtcagacacc tgttcggccc    180

ggcccggcgt ggtcgccggg ggccaggatg aaagtgaccg tgtgcttcgg caggacgggc    240

atcgtggtgc cctgcaagga gggccagctg cgcgtcggcg agctcaccca gcaggcgctg    300

cagcggtacc tgaagacccg ggagaagggt cctggttact gggtgaagat tcatcactta    360

gaatatacag atggaggaat cctggatcca gatgatgtct tggcagatgt tgttgaagat    420

aaagacaagg tactgattgc tgtgtttgaa gaacaagaac cactccacaa gattgagagc    480

cccagtggaa accctgcaga tcggcagagc ccagatgctt ttgagacaga agtggccgcc    540

caactggccg catttaagcc aattggtggg gagattgaag taaccccttc tgctctaaaa    600

ctaggcactc cactgctggt gaggagaagc agtgacccag tgccaggccc acctgctgat    660

acccagccaa gcgcttcaca ccctggtggc cagagtctga aactggttgt tccagattcc    720

acgcagaact tggaagacag agaagttttg aatggtgtac agacagaact actaacttcg    780

ccaagaacta aggacacatt gagtgatatg acaagaacag tggagatttc tggggaagga    840

ggcccattgg gaatacatgt agtgcccttc ttttcatctc tgagtggaag gattctagga    900

ctcttcatcc gaggcattga agacaacagc aggtccaagc gggagggact atttcacgaa    960

aatgaatgta ttgtaaaaat caacaatgtg gatctcgtag acaaaacctt tgctcaggct   1020

caagatgtct tccgccaggc aatgaaatct ccaagtgtgc tcctccacgt gcttcctcca   1080

caaaaccgtg aacagtatga aaagtcagtc attggctctc ttaacatttt tggtaataat   1140

gatggcgttt tgaaaaccaa agtgccgcct cctgtccatg gaaaatcggg actaaagaca   1200

gcaaatctca caggaaccga tagtcctgaa acagatgcat cagcttccct gcaacaaaac   1260

aagagtcccc gagtaccaag gctgggagga aaaccatcct ctccctcact ctcgcctctc   1320

atgggatttg gcagcaataa aaatgcaaag aaaattaaga ttgacctaaa gaaaggccct   1380

gaaggacttg gtttcactgt ggttaccaga gactcttcca tacatggtcc cggtcccatt   1440

tttgtaaaaa acattttacc aaagggagca gcaataaaag atggccgcct acaatcaggg   1500

gacagaattt tggaggtaaa tgggagagat gtcaccggac gaacccagga agagcttgtg   1560

gccatgctca ggagcaccaa gcagggggag acagcatcgc tggtcattgc ccgccaagaa   1620

ggacattttc tgccccgaga gttggatggt cgtctgcgaa tgaatgacca gctgattgca   1680

gttaatgggg aatctctttt gggaaagtcc aaccacgaag ctatggaaac acttaggcgg   1740

tcaatgtcca tggagggaaa catccgaggg atgatccagt tggtgattct gaggaggcca   1800

gagagaccaa tggaggatcc tgcagagtgt ggggcatttt ccaagccatg ctttgagaac   1860

tgtcaaaatg ctgtaaccac ctctaggcga aatgataata gtatcctgca tccacttggc   1920

acttgcagtc cacaagacaa acagaaaggt ctattgctgc ccaatgacgg atgggccgag   1980

agtgaagttc caccttctcc aacaccacat tctgctctgg gattgggcct cgaagattac   2040

agccacagct ctggggtgga ttcagcagta tattttccag atcagcacat caacttcaga   2100

tctgtgacac cggccaggca gcctgaatca attaatttga aagcctcgaa gagcatggac   2160

cttgtgccag atgaaagcaa ggttcactca ttggctggac aaaaatcgga atctccaagc   2220

aaagattttg gtccaactct gggtttgaaa aagtccagct ccttggagag tctgcagact   2280

gcagtggccg aggtcaggaa gaatgacctt ccctttcaca ggccccggcc gcacatggtt   2340

cgaggccgag gctgcaatga gagctttaga gcagccattg acaaatccta cgatggacct   2400

gaagaaatag aagctgacgg tctgtctgat aagagctctc actctggcca aggagctctg   2460

aattgtgagt ctgcccctca ggggaattcg gagctagagg acatggaaaa taaagccagg   2520

aaagtcaaaa aaacgaaaga gaaggagaag aaaaaggaaa agggcaaatt gaaagtcaag   2580

gagaaaaagc gcaaagagga gaatgaagat ccagaaagga aaataaagaa gaagggcttc   2640

ggcgccatgc tgagatttgg aaagaagaaa gaggataagg gtggaaaggc tgagcagaaa   2700

ggtactctga aacatggtgg cctgagagaa gaagagctgg agaaaatgaa agaagagcgt   2760

gaaaggattg gagcaaaaca tcaggagcta agggaaaagc aggcaagagg tcttcttgat   2820

tatgctactg gtgcaattgg atcagtgtat gatatggatg atgatgaaat ggaccccaat   2880

tatgccagag tgaaccactt tcgggaacca tgcacatcag caaatgtctt tagatctcca   2940

tctccccctc gagctggacc atttggttac cctcgggatg gccatccact gtctccagaa   3000

agagaccact tagagggtct ctatgccaag gtcaacaagc cataccatcc actggttcca   3060

gctgacagtg gccgtcctac gggtggaagc actgaccgta tccagaagtt gcggaaagag   3120

tattatcagg ctcggaggga aggtttccct ttatatgaag acgacgaagg aagagcaagg   3180

ccatctgagt atgacctact ctgggtgcct ggaaggggtc cagatgggaa tgcacacaac   3240

ctccgctttg aagggatgga gaggcagtac gcatccttac ccaggggagg acccgcagat   3300

cctgtagact atctgccagc agcacctcgg gggctctaca aggaaaggga gcttccctat   3360

tatccagggg ctcatcctat gcaccctccc aaagggagct atccccgccc cacagagctc   3420

agggtggcag atctccggta tcctcagcac tacccacccc cgccagctcc ccagcacaaa   3480

ggaccctttc gacaagacgt tccgccttcc cctccccagc accaaagaat gccagcctat   3540

caggaaacag gcagaccagg gccccgtggg ggcagcccag accagtaccc ttaccgaacc   3600

caggattccc ggcagaagaa ccccatgact gcagccgtat ag                      3642


<210>  706
<211>  1144
<212>  PRT
<213>  Homosapiens

<400>  706

Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Gly Pro Gly Tyr Trp Val Lys Ile 
        35                  40                  45              


His His Leu Glu Tyr Thr Asp Gly Gly Ile Leu Asp Pro Asp Asp Val 
    50                  55                  60                  


Leu Ala Asp Val Val Glu Asp Lys Asp Lys Val Leu Ile Ala Val Phe 
65                  70                  75                  80  


Glu Glu Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro 
                85                  90                  95      


Ala Asp Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln 
            100                 105                 110         


Leu Ala Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser 
        115                 120                 125             


Ala Leu Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro 
    130                 135                 140                 


Val Pro Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly 
145                 150                 155                 160 


Gly Gln Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu 
                165                 170                 175     


Asp Arg Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro 
            180                 185                 190         


Arg Thr Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser 
        195                 200                 205             


Gly Glu Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser 
    210                 215                 220                 


Leu Ser Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn 
225                 230                 235                 240 


Ser Arg Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val 
                245                 250                 255     


Lys Ile Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln 
            260                 265                 270         


Asp Val Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val 
        275                 280                 285             


Leu Pro Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser 
    290                 295                 300                 


Leu Asn Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro 
305                 310                 315                 320 


Pro Pro Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly 
                325                 330                 335     


Thr Asp Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys 
            340                 345                 350         


Ser Pro Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu 
        355                 360                 365             


Ser Pro Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys 
    370                 375                 380                 


Ile Asp Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr 
385                 390                 395                 400 


Arg Asp Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile 
                405                 410                 415     


Leu Pro Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp 
            420                 425                 430         


Arg Ile Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu 
        435                 440                 445             


Glu Leu Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser 
    450                 455                 460                 


Leu Val Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Asp 
465                 470                 475                 480 


Gly Arg Leu Arg Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser 
                485                 490                 495     


Leu Leu Gly Lys Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser 
            500                 505                 510         


Met Ser Met Glu Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu 
        515                 520                 525             


Arg Arg Pro Glu Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe 
    530                 535                 540                 


Ser Lys Pro Cys Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg 
545                 550                 555                 560 


Arg Asn Asp Asn Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln 
                565                 570                 575     


Asp Lys Gln Lys Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser 
            580                 585                 590         


Glu Val Pro Pro Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu 
        595                 600                 605             


Glu Asp Tyr Ser His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro 
    610                 615                 620                 


Asp Gln His Ile Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu 
625                 630                 635                 640 


Ser Ile Asn Leu Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu 
                645                 650                 655     


Ser Lys Val His Ser Leu Ala Gly Gln Lys Ser Glu Ser Pro Ser Lys 
            660                 665                 670         


Asp Phe Gly Pro Thr Leu Gly Leu Lys Lys Ser Ser Ser Leu Glu Ser 
        675                 680                 685             


Leu Gln Thr Ala Val Ala Glu Val Arg Lys Asn Asp Leu Pro Phe His 
    690                 695                 700                 


Arg Pro Arg Pro His Met Val Arg Gly Arg Gly Cys Asn Glu Ser Phe 
705                 710                 715                 720 


Arg Ala Ala Ile Asp Lys Ser Tyr Asp Gly Pro Glu Glu Ile Glu Ala 
                725                 730                 735     


Asp Gly Leu Ser Asp Lys Ser Ser His Ser Gly Gln Gly Ala Leu Asn 
            740                 745                 750         


Cys Glu Ser Ala Pro Gln Gly Asn Ser Glu Leu Glu Asp Met Glu Asn 
        755                 760                 765             


Lys Ala Arg Lys Val Lys Lys Thr Lys Glu Lys Glu Lys Lys Lys Glu 
    770                 775                 780                 


Lys Gly Lys Leu Lys Val Lys Glu Lys Lys Arg Lys Glu Glu Asn Glu 
785                 790                 795                 800 


Asp Pro Glu Arg Lys Ile Lys Lys Lys Gly Phe Gly Ala Met Leu Arg 
                805                 810                 815     


Phe Gly Lys Lys Lys Glu Asp Lys Gly Gly Lys Ala Glu Gln Lys Gly 
            820                 825                 830         


Thr Leu Lys His Gly Gly Leu Arg Glu Glu Glu Leu Glu Lys Met Lys 
        835                 840                 845             


Glu Glu Arg Glu Arg Ile Gly Ala Lys His Gln Glu Leu Arg Glu Lys 
    850                 855                 860                 


Gln Ala Arg Gly Leu Leu Asp Tyr Ala Thr Gly Ala Ile Gly Ser Val 
865                 870                 875                 880 


Tyr Asp Met Asp Asp Asp Glu Met Asp Pro Asn Tyr Ala Arg Val Asn 
                885                 890                 895     


His Phe Arg Glu Pro Cys Thr Ser Ala Asn Val Phe Arg Ser Pro Ser 
            900                 905                 910         


Pro Pro Arg Ala Gly Pro Phe Gly Tyr Pro Arg Asp Gly His Pro Leu 
        915                 920                 925             


Ser Pro Glu Arg Asp His Leu Glu Gly Leu Tyr Ala Lys Val Asn Lys 
    930                 935                 940                 


Pro Tyr His Pro Leu Val Pro Ala Asp Ser Gly Arg Pro Thr Gly Gly 
945                 950                 955                 960 


Ser Thr Asp Arg Ile Gln Lys Leu Arg Lys Glu Tyr Tyr Gln Ala Arg 
                965                 970                 975     


Arg Glu Gly Phe Pro Leu Tyr Glu Asp Asp Glu Gly Arg Ala Arg Pro 
            980                 985                 990         


Ser Glu Tyr Asp Leu Leu Trp Val  Pro Gly Arg Gly Pro  Asp Gly Asn 
        995                 1000                 1005             


Ala His  Asn Leu Arg Phe Glu  Gly Met Glu Arg Gln  Tyr Ala Ser 
    1010                 1015                 1020             


Leu Pro  Arg Gly Gly Pro Ala  Asp Pro Val Asp Tyr  Leu Pro Ala 
    1025                 1030                 1035             


Ala Pro  Arg Gly Leu Tyr Lys  Glu Arg Glu Leu Pro  Tyr Tyr Pro 
    1040                 1045                 1050             


Gly Ala  His Pro Met His Pro  Pro Lys Gly Ser Tyr  Pro Arg Pro 
    1055                 1060                 1065             


Thr Glu  Leu Arg Val Ala Asp  Leu Arg Tyr Pro Gln  His Tyr Pro 
    1070                 1075                 1080             


Pro Pro  Pro Ala Pro Gln His  Lys Gly Pro Phe Arg  Gln Asp Val 
    1085                 1090                 1095             


Pro Pro  Ser Pro Pro Gln His  Gln Arg Met Pro Ala  Tyr Gln Glu 
    1100                 1105                 1110             


Thr Gly  Arg Pro Gly Pro Arg  Gly Gly Ser Pro Asp  Gln Tyr Pro 
    1115                 1120                 1125             


Tyr Arg  Thr Gln Asp Ser Arg  Gln Lys Asn Pro Met  Thr Ala Ala 
    1130                 1135                 1140             


Val 
    


<210>  707
<211>  3525
<212>  DNA
<213>  Homosapiens

<400>  707
gcggccgccc ctccccgatt cccgccacct gccgcctggc caggtggaag gggcgctgcc     60

gcgagcctcc gggcctcagg gtgttccggg gagcggcgcc ccgggtctct gggcccaccc    120

gccccgggcg tcctccgaga gtgggggctg cgcccgcggg gtcagacacc tgttcggccc    180

ggcccggcgt ggtcgccggg ggccaggatg aaagtgaccg tgtgcttcgg caggacgggc    240

atcgtggtgc cctgcaagga gggccagctg cgcgtcggcg agctcaccca gcaggcgctg    300

cagcggtacc tgaagacccg ggagaagggt cctggttact gggtgaagat tcatcactta    360

gaatatacag atggaggaat cctggatcca gatgatgtct tggcagatgt tgttgaagat    420

aaagacaagg tactgattgc tgtgtttgaa gaacaagaac cactccacaa gattgagagc    480

cccagtggaa accctgcaga tcggcagagc ccagatgctt ttgagacaga agtggccgcc    540

caactggccg catttaagcc aattggtggg gagattgaag taaccccttc tgctctaaaa    600

ctaggcactc cactgctggt gaggagaagc agtgacccag tgccaggccc acctgctgat    660

acccagccaa gcgcttcaca ccctggtggc cagagtctga aactggttgt tccagattcc    720

acgcagaact tggaagacag agaagttttg aatggtgtac agacagaact actaacttcg    780

ccaagaacta aggacacatt gagtgatatg acaagaacag tggagatttc tggggaagga    840

ggcccattgg gaatacatgt agtgcccttc ttttcatctc tgagtggaag gattctagga    900

ctcttcatcc gaggcattga agacaacagc aggtccaagc gggagggact atttcacgaa    960

aatgaatgta ttgtaaaaat caacaatgtg gatctcgtag acaaaacctt tgctcaggct   1020

caagatgtct tccgccaggc aatgaaatct ccaagtgtgc tcctccacgt gcttcctcca   1080

caaaaccgtg aacagtatga aaagtcagtc attggctctc ttaacatttt tggtaataat   1140

gatggcgttt tgaaaaccaa agtgccgcct cctgtccatg gaaaatcggg actaaagaca   1200

gcaaatctca caggaaccga tagtcctgaa acagatgcat cagcttccct gcaacaaaac   1260

aagagtcccc gagtaccaag gctgggagga aaaccatcct ctccctcact ctcgcctctc   1320

atgggatttg gcagcaataa aaatgcaaag aaaattaaga ttgacctaaa gaaaggccct   1380

gaaggacttg gtttcactgt ggttaccaga gactcttcca tacatggtcc cggtcccatt   1440

tttgtaaaaa acattttacc aaagggagca gcaataaaag atggccgcct acaatcaggg   1500

gacagaattt tggaggtaaa tgggagagat gtcaccggac gaacccagga agagcttgtg   1560

gccatgctca ggagcaccaa gcagggggag acagcatcgc tggtcattgc ccgccaagaa   1620

ggacattttc tgccccgaga gttgaaagga gaacctgact gctgtgcact ctctctggag   1680

acaagcgagc agctcacctt tgagatcccc ctgaatgatt caggttctgc tggcctcggg   1740

gtgagcttaa aagggaacaa atccagagaa actggaacag acttggggat ttttatcaaa   1800

tccatcattc atggaggcgc tgcttttaag gatggtcgtc tgcgaatgaa tgaccagctg   1860

attgcagtta atggggaatc tcttttggga aagtccaacc acgaagctat ggaaacactt   1920

aggcggtcaa tgtccatgga gggaaacatc cgagggatga tccagttggt gattctgagg   1980

aggccagaga gaccaatgga ggatcctgca gagtgtgggg cattttccaa gccatgcttt   2040

gagaactgtc aaaatgctgt aaccacctct aggcgaaatg ataatagtat cctgcatcca   2100

cttggcactt gcagtccaca agacaaacag aaaggtctat tgctgcccaa tgacggatgg   2160

gccgagagtg aagttccacc ttctccaaca ccacattctg ctctgggatt gggcctcgaa   2220

gattacagcc acagctctgg ggtggattca gcagtatatt ttccagatca gcacatcaac   2280

ttcagatctg tgacaccggc caggcagcct gaatcaatta atttgaaagc ctcgaagagc   2340

atggaccttg tgccagatga aagcaaggtt cactcattgg ctggacaaaa atcggaatct   2400

ccaagcaaag attttggtcc aactctgggt ttgaaaaagt ccagctcctt ggagagtctg   2460

cagactgcag tggccgaggt caggaagaat gaccttccct ttcacaggcc ccggccgcac   2520

atggttcgag gccgaggctg caatgagagc tttagagcag ccattgacaa atcctacgat   2580

ggacctgaag aaatagaagc tgacggtctg tctgataaga gctctcactc tggccaagga   2640

gctctgaatt gtgagtctgc ccctcagggg aattcggagc tagaggacat ggaaaataaa   2700

gccaggaaag tcaaaaaaac gaaagagaag gagaagaaaa aggaaaaggg caaattgaaa   2760

gtcaaggaga aaaagcgcaa agaggagaat gaagatccag aaaggaaaat aaagaagaag   2820

ggcttcggcg ccatgctgag atttggaaag aagaaagagg ataagggtgg aaaggctgag   2880

cagaaaggta ctctgaaaca tggtggcctg agagaagaag agctggagaa aatgaaagaa   2940

gagcgtgaaa gtggccgtcc tacgggtgga agcactgacc gtatccagaa gttgcggaaa   3000

gagtattatc aggctcggag ggaaggtttc cctttatatg aagacgacga aggaagagca   3060

aggccatctg agtatgacct actctgggtg cctggaaggg gtccagatgg gaatgcacac   3120

aacctccgct ttgaagggat ggagaggcag tacgcatcct tacccagggg aggacccgca   3180

gatcctgtag actatctgcc agcagcacct cgggggctct acaaggaaag ggagcttccc   3240

tattatccag gggctcatcc tatgcaccct cccaaaggga gctatccccg ccccacagag   3300

ctcagggtgg cagatctccg gtatcctcag cactacccac ccccgccagc tccccagcac   3360

aaaggaccct ttcgacaaga cgttccgcct tcccctcccc agcaccaaag aatgccagcc   3420

tatcaggaaa caggcagacc agggccccgt gggggcagcc cagaccagta cccttaccga   3480

acccaggatt cccggcagaa gaaccccatg actgcagccg tatag                   3525


<210>  708
<211>  1105
<212>  PRT
<213>  Homosapiens

<400>  708

Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Gly Pro Gly Tyr Trp Val Lys Ile 
        35                  40                  45              


His His Leu Glu Tyr Thr Asp Gly Gly Ile Leu Asp Pro Asp Asp Val 
    50                  55                  60                  


Leu Ala Asp Val Val Glu Asp Lys Asp Lys Val Leu Ile Ala Val Phe 
65                  70                  75                  80  


Glu Glu Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro 
                85                  90                  95      


Ala Asp Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln 
            100                 105                 110         


Leu Ala Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser 
        115                 120                 125             


Ala Leu Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro 
    130                 135                 140                 


Val Pro Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly 
145                 150                 155                 160 


Gly Gln Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu 
                165                 170                 175     


Asp Arg Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro 
            180                 185                 190         


Arg Thr Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser 
        195                 200                 205             


Gly Glu Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser 
    210                 215                 220                 


Leu Ser Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn 
225                 230                 235                 240 


Ser Arg Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val 
                245                 250                 255     


Lys Ile Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln 
            260                 265                 270         


Asp Val Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val 
        275                 280                 285             


Leu Pro Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser 
    290                 295                 300                 


Leu Asn Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro 
305                 310                 315                 320 


Pro Pro Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly 
                325                 330                 335     


Thr Asp Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys 
            340                 345                 350         


Ser Pro Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu 
        355                 360                 365             


Ser Pro Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys 
    370                 375                 380                 


Ile Asp Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr 
385                 390                 395                 400 


Arg Asp Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile 
                405                 410                 415     


Leu Pro Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp 
            420                 425                 430         


Arg Ile Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu 
        435                 440                 445             


Glu Leu Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser 
    450                 455                 460                 


Leu Val Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Lys 
465                 470                 475                 480 


Gly Glu Pro Asp Cys Cys Ala Leu Ser Leu Glu Thr Ser Glu Gln Leu 
                485                 490                 495     


Thr Phe Glu Ile Pro Leu Asn Asp Ser Gly Ser Ala Gly Leu Gly Val 
            500                 505                 510         


Ser Leu Lys Gly Asn Lys Ser Arg Glu Thr Gly Thr Asp Leu Gly Ile 
        515                 520                 525             


Phe Ile Lys Ser Ile Ile His Gly Gly Ala Ala Phe Lys Asp Gly Arg 
    530                 535                 540                 


Leu Arg Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu Leu 
545                 550                 555                 560 


Gly Lys Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met Ser 
                565                 570                 575     


Met Glu Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg Arg 
            580                 585                 590         


Pro Glu Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser Lys 
        595                 600                 605             


Pro Cys Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg Asn 
    610                 615                 620                 


Asp Asn Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp Lys 
625                 630                 635                 640 


Gln Lys Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu Val 
                645                 650                 655     


Pro Pro Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu Asp 
            660                 665                 670         


Tyr Ser His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp Gln 
        675                 680                 685             


His Ile Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser Ile 
    690                 695                 700                 


Asn Leu Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser Lys 
705                 710                 715                 720 


Val His Ser Leu Ala Gly Gln Lys Ser Glu Ser Pro Ser Lys Asp Phe 
                725                 730                 735     


Gly Pro Thr Leu Gly Leu Lys Lys Ser Ser Ser Leu Glu Ser Leu Gln 
            740                 745                 750         


Thr Ala Val Ala Glu Val Arg Lys Asn Asp Leu Pro Phe His Arg Pro 
        755                 760                 765             


Arg Pro His Met Val Arg Gly Arg Gly Cys Asn Glu Ser Phe Arg Ala 
    770                 775                 780                 


Ala Ile Asp Lys Ser Tyr Asp Gly Pro Glu Glu Ile Glu Ala Asp Gly 
785                 790                 795                 800 


Leu Ser Asp Lys Ser Ser His Ser Gly Gln Gly Ala Leu Asn Cys Glu 
                805                 810                 815     


Ser Ala Pro Gln Gly Asn Ser Glu Leu Glu Asp Met Glu Asn Lys Ala 
            820                 825                 830         


Arg Lys Val Lys Lys Thr Lys Glu Lys Glu Lys Lys Lys Glu Lys Gly 
        835                 840                 845             


Lys Leu Lys Val Lys Glu Lys Lys Arg Lys Glu Glu Asn Glu Asp Pro 
    850                 855                 860                 


Glu Arg Lys Ile Lys Lys Lys Gly Phe Gly Ala Met Leu Arg Phe Gly 
865                 870                 875                 880 


Lys Lys Lys Glu Asp Lys Gly Gly Lys Ala Glu Gln Lys Gly Thr Leu 
                885                 890                 895     


Lys His Gly Gly Leu Arg Glu Glu Glu Leu Glu Lys Met Lys Glu Glu 
            900                 905                 910         


Arg Glu Ser Gly Arg Pro Thr Gly Gly Ser Thr Asp Arg Ile Gln Lys 
        915                 920                 925             


Leu Arg Lys Glu Tyr Tyr Gln Ala Arg Arg Glu Gly Phe Pro Leu Tyr 
    930                 935                 940                 


Glu Asp Asp Glu Gly Arg Ala Arg Pro Ser Glu Tyr Asp Leu Leu Trp 
945                 950                 955                 960 


Val Pro Gly Arg Gly Pro Asp Gly Asn Ala His Asn Leu Arg Phe Glu 
                965                 970                 975     


Gly Met Glu Arg Gln Tyr Ala Ser Leu Pro Arg Gly Gly Pro Ala Asp 
            980                 985                 990         


Pro Val Asp Tyr Leu Pro Ala Ala  Pro Arg Gly Leu Tyr  Lys Glu Arg 
        995                 1000                 1005             


Glu Leu  Pro Tyr Tyr Pro Gly  Ala His Pro Met His  Pro Pro Lys 
    1010                 1015                 1020             


Gly Ser  Tyr Pro Arg Pro Thr  Glu Leu Arg Val Ala  Asp Leu Arg 
    1025                 1030                 1035             


Tyr Pro  Gln His Tyr Pro Pro  Pro Pro Ala Pro Gln  His Lys Gly 
    1040                 1045                 1050             


Pro Phe  Arg Gln Asp Val Pro  Pro Ser Pro Pro Gln  His Gln Arg 
    1055                 1060                 1065             


Met Pro  Ala Tyr Gln Glu Thr  Gly Arg Pro Gly Pro  Arg Gly Gly 
    1070                 1075                 1080             


Ser Pro  Asp Gln Tyr Pro Tyr  Arg Thr Gln Asp Ser  Arg Gln Lys 
    1085                 1090                 1095             


Asn Pro  Met Thr Ala Ala Val  
    1100                 1105 


<210>  709
<211>  2490
<212>  DNA
<213>  Homosapiens

<400>  709
gggcttggct tggagggggc aagggaggga aagagagaag ggggaaacac aaaaaacttc     60

tttctttccc cctccgttta tcttcagccc gacattgtca cctcctcttt gaggggttag    120

aagaagctga gatctcccga cagagctgga aatgcattgc actttgacta tggaaacaga    180

cgctattgat ggctatataa cgtgtgacaa tgagctttca cccgaaaggg agcactccaa    240

tatggcaatt gacctcacct caagcacacc caatggacag catgcctcac caagtcacat    300

gacaagcaca aattcagtaa agctagaaat gcagagtgat gaagagtgtg acaggaaacc    360

cctgagccgt gaaaatgaga tcaggggcca tgatgagggt agcagcctag aagaacccct    420

aattgagagc agcgaggtgg ctgacaacag gaaagtccag gagcttcaag gcgagggagg    480

aatccggctt ccgaatggta aactgaaatg tgacgtctgt ggcatggttt gcattgggcc    540

caatgtgctt atggtacata aaaggagtca cactggtgaa cgccccttcc actgtaacca    600

gtgtggagct tcttttactc agaagggcaa ccttctgaga cacataaagt tacactctgg    660

agagaagccg ttcaaatgtc ctttctgtag ctacgcctgt agaagaaggg acgccctcac    720

aggacacctc aggacccatt ctgtgggtaa acctcacaag tgcaactact gtggacgaag    780

ctacaagcag cgcagttcac tggaggagca caaggaacgc tgccacaact atctccagaa    840

tgtcagcatg gaggctgctg ggcaggtcat gagtcaccat gtacctccta tggaagattg    900

taaggaacaa gagcctatta tggacaacaa tatttctctg gtgccttttg agagacctgc    960

tgtcatagag aagctcacgg ggaatatggg aaaacgtaaa agctccactc cacaaaagtt   1020

tgtgggggaa aagctcatgc gattcagcta cccagatatt cactttgata tgaacttaac   1080

atatgagaag gaggctgagc tgatgcagtc tcatatgatg gaccaagcca tcaacaatgc   1140

aatcacctac cttggagctg aggcccttca ccctctgatg cagcacccgc caagcacaat   1200

cgctgaagtg gccccagtta taagctcagc ttattctcag gtctatcatc caaataggat   1260

agaaagaccc attagcaggg aaactgctga tagtcatgaa aacaacatgg atggccccat   1320

ctctctcatc agaccaaaga gtcgacccca ggaaagagag gcctctccca gcaatagctg   1380

cctggattcc actgactcag aaagcagcca tgatgaccac cagtcctacc aaggacaccc   1440

tgccttaaat cccaagagga aacaaagccc agcttacatg aaggaggatg tcaaagcttt   1500

ggatactacc aaggctccta agggctctct gaaggacatc tacaaggtct tcaatggaga   1560

aggagaacag attagggcct tcaagtgtga gcactgccga gtccttttcc tagaccatgt   1620

catgtacacc attcacatgg gttgccatgg ctaccgggac ccactggaat gcaacatctg   1680

tggctacaga agccaggacc gttatgagtt ttcatcacac attgttcgag gggagcacac   1740

attccactag gccttttcat tccaaagggg acccctatga agtaaagaac tgcacatgaa   1800

gaaataccgc acttacaatc ccacctttcc tcaaatgttg acataccttt tatttttttt   1860

aatattatta ctgttgataa ttcttatttt gtggaggcag tgtcatttgc tctgcctaat   1920

tacgataagg aagaaacaga agagagaagg ggcgggaata ttgtttcttt atcacctggc   1980

ttgtttattt tgtgggaatt taagagcagt ccatttctac caaggcatat catgctttga   2040

aaaatcactt gattcataaa gattcaccta agagattctg atttgccact gatattcaga   2100

attatgatgg aagacaggaa agtttagagt tttctgggca ggactttggt ggtttaaaaa   2160

tggtataagt aactttattc ttgaaagaag aatgtgtttc aaactgtaaa ccaatttttt   2220

gttcttcaga gatcatggaa cacaaacaca ttgttatttt cagtgataac tcctaagagg   2280

agctgagttg ttgtgggttc tatgtttact tcccctatgg aatttataat tcagtatgtt   2340

ttacactgta ccatatagca aaacttttaa actacaggta gttaagggcc acctacaata   2400

catctgaggt cctgtgatct tatttttcta aacgtaagca ctgtttttcc atagttttga   2460

tgactggcat tttatagaca ccctggcagc                                    2490


<210>  710
<211>  526
<212>  PRT
<213>  Homosapiens

<400>  710

Met Glu Thr Asp Ala Ile Asp Gly Tyr Ile Thr Cys Asp Asn Glu Leu 
1               5                   10                  15      


Ser Pro Glu Arg Glu His Ser Asn Met Ala Ile Asp Leu Thr Ser Ser 
            20                  25                  30          


Thr Pro Asn Gly Gln His Ala Ser Pro Ser His Met Thr Ser Thr Asn 
        35                  40                  45              


Ser Val Lys Leu Glu Met Gln Ser Asp Glu Glu Cys Asp Arg Lys Pro 
    50                  55                  60                  


Leu Ser Arg Glu Asn Glu Ile Arg Gly His Asp Glu Gly Ser Ser Leu 
65                  70                  75                  80  


Glu Glu Pro Leu Ile Glu Ser Ser Glu Val Ala Asp Asn Arg Lys Val 
                85                  90                  95      


Gln Glu Leu Gln Gly Glu Gly Gly Ile Arg Leu Pro Asn Gly Lys Leu 
            100                 105                 110         


Lys Cys Asp Val Cys Gly Met Val Cys Ile Gly Pro Asn Val Leu Met 
        115                 120                 125             


Val His Lys Arg Ser His Thr Gly Glu Arg Pro Phe His Cys Asn Gln 
    130                 135                 140                 


Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu Leu Arg His Ile Lys 
145                 150                 155                 160 


Leu His Ser Gly Glu Lys Pro Phe Lys Cys Pro Phe Cys Ser Tyr Ala 
                165                 170                 175     


Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu Arg Thr His Ser Val 
            180                 185                 190         


Gly Lys Pro His Lys Cys Asn Tyr Cys Gly Arg Ser Tyr Lys Gln Arg 
        195                 200                 205             


Ser Ser Leu Glu Glu His Lys Glu Arg Cys His Asn Tyr Leu Gln Asn 
    210                 215                 220                 


Val Ser Met Glu Ala Ala Gly Gln Val Met Ser His His Val Pro Pro 
225                 230                 235                 240 


Met Glu Asp Cys Lys Glu Gln Glu Pro Ile Met Asp Asn Asn Ile Ser 
                245                 250                 255     


Leu Val Pro Phe Glu Arg Pro Ala Val Ile Glu Lys Leu Thr Gly Asn 
            260                 265                 270         


Met Gly Lys Arg Lys Ser Ser Thr Pro Gln Lys Phe Val Gly Glu Lys 
        275                 280                 285             


Leu Met Arg Phe Ser Tyr Pro Asp Ile His Phe Asp Met Asn Leu Thr 
    290                 295                 300                 


Tyr Glu Lys Glu Ala Glu Leu Met Gln Ser His Met Met Asp Gln Ala 
305                 310                 315                 320 


Ile Asn Asn Ala Ile Thr Tyr Leu Gly Ala Glu Ala Leu His Pro Leu 
                325                 330                 335     


Met Gln His Pro Pro Ser Thr Ile Ala Glu Val Ala Pro Val Ile Ser 
            340                 345                 350         


Ser Ala Tyr Ser Gln Val Tyr His Pro Asn Arg Ile Glu Arg Pro Ile 
        355                 360                 365             


Ser Arg Glu Thr Ala Asp Ser His Glu Asn Asn Met Asp Gly Pro Ile 
    370                 375                 380                 


Ser Leu Ile Arg Pro Lys Ser Arg Pro Gln Glu Arg Glu Ala Ser Pro 
385                 390                 395                 400 


Ser Asn Ser Cys Leu Asp Ser Thr Asp Ser Glu Ser Ser His Asp Asp 
                405                 410                 415     


His Gln Ser Tyr Gln Gly His Pro Ala Leu Asn Pro Lys Arg Lys Gln 
            420                 425                 430         


Ser Pro Ala Tyr Met Lys Glu Asp Val Lys Ala Leu Asp Thr Thr Lys 
        435                 440                 445             


Ala Pro Lys Gly Ser Leu Lys Asp Ile Tyr Lys Val Phe Asn Gly Glu 
    450                 455                 460                 


Gly Glu Gln Ile Arg Ala Phe Lys Cys Glu His Cys Arg Val Leu Phe 
465                 470                 475                 480 


Leu Asp His Val Met Tyr Thr Ile His Met Gly Cys His Gly Tyr Arg 
                485                 490                 495     


Asp Pro Leu Glu Cys Asn Ile Cys Gly Tyr Arg Ser Gln Asp Arg Tyr 
            500                 505                 510         


Glu Phe Ser Ser His Ile Val Arg Gly Glu His Thr Phe His 
        515                 520                 525     


<210>  711
<211>  1296
<212>  DNA
<213>  Homosapiens

<400>  711
gagagctccc gggggccgtt gggtagcgtc ttcgctgttg cccttaggga cggctgtggg     60

cctgctgggg gtgggggccc gaagcgccag agatggctgc tcagcgaggg atgcccagct    120

ccgccgtgag ggtcctggaa gaggcgttgg gcatgggttt gacggcagcc ggggacgcga    180

gggacacggc ggacgcggtg gcggctgagg gcgcctacta cctggaacag gtcaccataa    240

ctgaagcatc tgaagatgac tatgaatatg aagagatacc agatgacaat tttagcatcc    300

cagaaggtga agaagatctg gcaaaagcaa ttcagatggc ccaagaacag gctacagata    360

ctgaaatttt ggaacggaaa acagttcttc cttcaaagca tgcagtacct gaagtaatag    420

aagactttct ctgcaatttc ttgatcaaaa tgggaatgac cagaactctt gattgctttc    480

agtctgaatg gtatgagtta atacagaaag gagtgactga acttagaact gttgggaatg    540

ttccagatgt ctacacccag attatgcttt tggaaaatga gaacaaaaat ttaaagaaag    600

atttgaagca ctacaaacaa gcagctgagt atgttatttt ttaaatgaca ttttcttctt    660

tttcttttgg actaaataaa agagttgagt gaagctgata tatgtaatat accagagcct    720

taatttttga aaactgaatt tttctagttg taaagaatgt gagaggcttc attagcaaat    780

taattaaaca gatgatcaga actatcacaa ttataactta ccaacaagaa gggaatgcag    840

gtagttgttt aggagatggt acatttttta tataacattc acttccttgt gtatttgata    900

gtcttttcat ggtttataac attttctcct gtaaagatag gctaatttct gaaataataa    960

ttaaatttat agaaagccga gaggaaattg ctagtttatt cctggtagag gaatttctgt   1020

atttgaaaat tctccagaag gaataatata aactgtggac tttgggtgat aatgatatgt   1080

aggttcgtca gttgttaaca aatgtatccc tctgttgggg gctattgata atggggaagg   1140

ctgtgcatgt gtgggagtag gaggtgtatg ggacatctct gtaccttcta atcaattttg   1200

ctatgaactt aaaactgctc taaaaataaa gtttattaaa aaaaagttaa aaaaaaaaaa   1260

aaaaaaaaaa aaaaaaaaaa agaaaaaaaa aaaaaa                             1296


<210>  712
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  712

Met Ala Ala Gln Arg Gly Met Pro Ser Ser Ala Val Arg Val Leu Glu 
1               5                   10                  15      


Glu Ala Leu Gly Met Gly Leu Thr Ala Ala Gly Asp Ala Arg Asp Thr 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Glu Gly Ala Tyr Tyr Leu Glu Gln Val Thr 
        35                  40                  45              


Ile Thr Glu Ala Ser Glu Asp Asp Tyr Glu Tyr Glu Glu Ile Pro Asp 
    50                  55                  60                  


Asp Asn Phe Ser Ile Pro Glu Gly Glu Glu Asp Leu Ala Lys Ala Ile 
65                  70                  75                  80  


Gln Met Ala Gln Glu Gln Ala Thr Asp Thr Glu Ile Leu Glu Arg Lys 
                85                  90                  95      


Thr Val Leu Pro Ser Lys His Ala Val Pro Glu Val Ile Glu Asp Phe 
            100                 105                 110         


Leu Cys Asn Phe Leu Ile Lys Met Gly Met Thr Arg Thr Leu Asp Cys 
        115                 120                 125             


Phe Gln Ser Glu Trp Tyr Glu Leu Ile Gln Lys Gly Val Thr Glu Leu 
    130                 135                 140                 


Arg Thr Val Gly Asn Val Pro Asp Val Tyr Thr Gln Ile Met Leu Leu 
145                 150                 155                 160 


Glu Asn Glu Asn Lys Asn Leu Lys Lys Asp Leu Lys His Tyr Lys Gln 
                165                 170                 175     


Ala Ala Glu Tyr Val Ile Phe 
            180             


<210>  713
<211>  2189
<212>  DNA
<213>  Homosapiens

<400>  713
gagagctccc gggggccgtt gggtagcgtc ttcgctgttg cccttaggga cggctgtggg     60

cctgctgggg gtgggggccc gaagcgccag agatggctgc tcagcgaggg atgcccagct    120

ccgccgtgag ggtcctggaa gaggcgttgg gcatgggttt gacggcagcc ggggacgcga    180

gggacacggc ggacgcggtg gcggctgagg gcgcctacta cctggaacag gtcaccataa    240

ctgaagcatc tgaagatgac tatgaatatg aagagatacc agatgacaat tttagcatcc    300

cagaaggtga agaagatctg gcaaaagcaa ttcagatggc ccaagaacag gctacagata    360

ctgaaatttt ggaacggaaa acagttcttc cttcaaagca tgcagtacct gaagtaatag    420

aagactttct ctgcaatttc ttgatcaaaa tgggaatgac cagaactctt gattgctttc    480

agtctgaatg gtatgagtta atacagaaag gagtgactga acttagaact gttgggaatg    540

ttccagatgt ctacacccag attatgcttt tggaaaatga gaacaaaaat ttaaagaaag    600

atttgaagca ctacaaacaa gcagctgaca aagctagaga agatttgctg aaaattcaga    660

aagaacgtga ttttcatcga atgcatcata agcgaatagt ccaggaaaaa aacaaattaa    720

ttaatgacct caaagggttg aagttacatt atgcatctta tgaaccgact ataagggtgt    780

tacatgagaa acaccacact ttactgaagg agaaaatgct gacctccttg gaaagagaca    840

aagtagttgg gcagatttct ggacttcaag aaacattgaa gaaactgcaa agaggacata    900

gttaccatgg tcctcaaatt aaagttgatc atagtcgtga aaaagaaaat gcaccagaag    960

gtcctactca gaaaggtctt cgtgaagcca gggaacaaaa caaatgtaaa acaaagatga   1020

aaggcaatac aaaggattca gaatttccca tagatatgca accaaatcca aacctgaatg   1080

tttctaaaga aagtctttct ccagcaaaat ttgactacaa gctgaaaaac atttttagac   1140

tccatgaact tccagtgagc tgtgtctcca tgcaacccca caaagacatc ctagtctcct   1200

gtggcgagga ccgactctgg aaggtgttgg gccttccaaa atgcaatgtg cttctcacgg   1260

gatttggcca cactgactgg ctttcagact gctgcttcca tcccagtggc gacaaattgg   1320

ctacttcaag tggtgacact acagttaaat tatgggatct atgtaaaggc gattgcattt   1380

tgacctttga aggacacagc cgcgcagtgt ggtcctgcac atggcactcc tgcggcaatt   1440

ttgtggcttc ctcctcactg gataaaacta gcaaaatttg ggatgttaat agtgaaagat   1500

gcagatgtac tttgtatgga catacagatt ctgtgaacag cattgagttt tttcctttct   1560

ccaatactct tctcacaagc tctgcagaca agaccctgtc tatatgggat gcaagaacag   1620

gtatatgtga gcagtcactt tatggtcaca tgcattctat caatgatgcc atttttgatc   1680

ccaggggtca catgatagca tcctgtgatg cctgtggggt tacaaagctg tgggactttc   1740

ggaagctgtt accaattgtg tccatcgata taggtccaag tcctggcaat gaggtgaatt   1800

ttgattcatc aggtcgagtt ttagctcagg caagtggcaa tggtgttatc catttgctag   1860

atcttaaatc tggggagatt cacaaattga tgggccacga aaacgaggca cacacggttg   1920

tgttttctca cgacggggag attctctttt ctggaggctc tgacggcaca gttcgaacgt   1980

ggtcttgacc gtcagcacat cccgctgcag agggcattcc ctttaaggct tgaaaatgcc   2040

tcctgtagtc ccaaaccagc aaagaactgg ttaaatgtgc cagcaggtaa catttacagt   2100

ctgctttaaa acatgctttg gacatatatt ttagtgctca tactgttact aataaaaaaa   2160

taactttatg ctcaaaaaaa aaaaaaaaa                                     2189


<210>  714
<211>  631
<212>  PRT
<213>  Homosapiens

<400>  714

Met Ala Ala Gln Arg Gly Met Pro Ser Ser Ala Val Arg Val Leu Glu 
1               5                   10                  15      


Glu Ala Leu Gly Met Gly Leu Thr Ala Ala Gly Asp Ala Arg Asp Thr 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Glu Gly Ala Tyr Tyr Leu Glu Gln Val Thr 
        35                  40                  45              


Ile Thr Glu Ala Ser Glu Asp Asp Tyr Glu Tyr Glu Glu Ile Pro Asp 
    50                  55                  60                  


Asp Asn Phe Ser Ile Pro Glu Gly Glu Glu Asp Leu Ala Lys Ala Ile 
65                  70                  75                  80  


Gln Met Ala Gln Glu Gln Ala Thr Asp Thr Glu Ile Leu Glu Arg Lys 
                85                  90                  95      


Thr Val Leu Pro Ser Lys His Ala Val Pro Glu Val Ile Glu Asp Phe 
            100                 105                 110         


Leu Cys Asn Phe Leu Ile Lys Met Gly Met Thr Arg Thr Leu Asp Cys 
        115                 120                 125             


Phe Gln Ser Glu Trp Tyr Glu Leu Ile Gln Lys Gly Val Thr Glu Leu 
    130                 135                 140                 


Arg Thr Val Gly Asn Val Pro Asp Val Tyr Thr Gln Ile Met Leu Leu 
145                 150                 155                 160 


Glu Asn Glu Asn Lys Asn Leu Lys Lys Asp Leu Lys His Tyr Lys Gln 
                165                 170                 175     


Ala Ala Asp Lys Ala Arg Glu Asp Leu Leu Lys Ile Gln Lys Glu Arg 
            180                 185                 190         


Asp Phe His Arg Met His His Lys Arg Ile Val Gln Glu Lys Asn Lys 
        195                 200                 205             


Leu Ile Asn Asp Leu Lys Gly Leu Lys Leu His Tyr Ala Ser Tyr Glu 
    210                 215                 220                 


Pro Thr Ile Arg Val Leu His Glu Lys His His Thr Leu Leu Lys Glu 
225                 230                 235                 240 


Lys Met Leu Thr Ser Leu Glu Arg Asp Lys Val Val Gly Gln Ile Ser 
                245                 250                 255     


Gly Leu Gln Glu Thr Leu Lys Lys Leu Gln Arg Gly His Ser Tyr His 
            260                 265                 270         


Gly Pro Gln Ile Lys Val Asp His Ser Arg Glu Lys Glu Asn Ala Pro 
        275                 280                 285             


Glu Gly Pro Thr Gln Lys Gly Leu Arg Glu Ala Arg Glu Gln Asn Lys 
    290                 295                 300                 


Cys Lys Thr Lys Met Lys Gly Asn Thr Lys Asp Ser Glu Phe Pro Ile 
305                 310                 315                 320 


Asp Met Gln Pro Asn Pro Asn Leu Asn Val Ser Lys Glu Ser Leu Ser 
                325                 330                 335     


Pro Ala Lys Phe Asp Tyr Lys Leu Lys Asn Ile Phe Arg Leu His Glu 
            340                 345                 350         


Leu Pro Val Ser Cys Val Ser Met Gln Pro His Lys Asp Ile Leu Val 
        355                 360                 365             


Ser Cys Gly Glu Asp Arg Leu Trp Lys Val Leu Gly Leu Pro Lys Cys 
    370                 375                 380                 


Asn Val Leu Leu Thr Gly Phe Gly His Thr Asp Trp Leu Ser Asp Cys 
385                 390                 395                 400 


Cys Phe His Pro Ser Gly Asp Lys Leu Ala Thr Ser Ser Gly Asp Thr 
                405                 410                 415     


Thr Val Lys Leu Trp Asp Leu Cys Lys Gly Asp Cys Ile Leu Thr Phe 
            420                 425                 430         


Glu Gly His Ser Arg Ala Val Trp Ser Cys Thr Trp His Ser Cys Gly 
        435                 440                 445             


Asn Phe Val Ala Ser Ser Ser Leu Asp Lys Thr Ser Lys Ile Trp Asp 
    450                 455                 460                 


Val Asn Ser Glu Arg Cys Arg Cys Thr Leu Tyr Gly His Thr Asp Ser 
465                 470                 475                 480 


Val Asn Ser Ile Glu Phe Phe Pro Phe Ser Asn Thr Leu Leu Thr Ser 
                485                 490                 495     


Ser Ala Asp Lys Thr Leu Ser Ile Trp Asp Ala Arg Thr Gly Ile Cys 
            500                 505                 510         


Glu Gln Ser Leu Tyr Gly His Met His Ser Ile Asn Asp Ala Ile Phe 
        515                 520                 525             


Asp Pro Arg Gly His Met Ile Ala Ser Cys Asp Ala Cys Gly Val Thr 
    530                 535                 540                 


Lys Leu Trp Asp Phe Arg Lys Leu Leu Pro Ile Val Ser Ile Asp Ile 
545                 550                 555                 560 


Gly Pro Ser Pro Gly Asn Glu Val Asn Phe Asp Ser Ser Gly Arg Val 
                565                 570                 575     


Leu Ala Gln Ala Ser Gly Asn Gly Val Ile His Leu Leu Asp Leu Lys 
            580                 585                 590         


Ser Gly Glu Ile His Lys Leu Met Gly His Glu Asn Glu Ala His Thr 
        595                 600                 605             


Val Val Phe Ser His Asp Gly Glu Ile Leu Phe Ser Gly Gly Ser Asp 
    610                 615                 620                 


Gly Thr Val Arg Thr Trp Ser 
625                 630     


<210>  715
<211>  4530
<212>  DNA
<213>  Homosapiens

<400>  715
gctcggagcg ggctccgcgg cttgcaaggc gcctgcgact cggtcccagg tcggcgggcg     60

gcgcacggcg ggctcgcgcg ggggccccgg cgcgccgggc ggcgcagtac gcagcgcgcg    120

gacccacgcc acggccagga gcccagagca gcgcggccac actgcccagg ggtcggccct    180

cggccccggc gctcggagcg cggcggctgc ctgggcttta atggctgctc cgcggagcag    240

cgcctagggc tggaaggcgg ctgcggctca ggaagtcacc cgagcaagcc tccttcgggg    300

ccggccgcac ccgccgcggc gcgctccatg ggggcgcgct ccccccgggc ggcccgctga    360

cccgggacgc cggggcccgc tcgctcgccg gccgcgcgtc ccggccatga actgagcccg    420

cgggccagcc ccgcgcctgc tccgcccgcg cctttcttct cgcgcctcct ccgcccgccg    480

ccggcgggcc cggctccccg ggggctgcgg cgccccgggc tcggcggccc gcgggccccg    540

gggcgcgggg cggcggcggc ggggggcgcg cggctccggg cgcggcgcct gcaccatgaa    600

ctaccagcag cagctggcca actcggctgc catccgggcc gagatccagc gcttcgagtc    660

ggtccacccc aacatctact ccatctacga gctgctggag cgcgtggagg agccggtgct    720

gcagaaccag atccgggagc acgtcatcgc catcgaagat gccttcgtga acagccagga    780

atggacgctg agtcgatctg tcccggagct caaagtggga attgtgggta acttggccag    840

cggcaagtct gccctggtgc accggtacct gacgggcaca tatgtccagg aggagtctcc    900

ggaaggtggc aggttcaaga aagagattgt cgttgatgga cagagctatc tgctgctgat    960

cagagatgaa gggggccccc cggaggcgca gtttgccatg tgggtggacg ctgttatatt   1020

tgtcttcagc ttggaggatg aaataagttt ccagaccgtt taccactact acagtcgaat   1080

ggccaactat cggaacacga gcgagattcc tctggttctg gtgggaaccc aggatgccat   1140

aagttctgct aacccgaggg tcatcgatga cgccagggcg aggaagctct ccaacgacct   1200

gaaacggtgc acgtactacg agacgtgtgc tacatacggg ctgaatgtgg agagggtctt   1260

ccaggacgtt gcccagaaga ttgttgccac aaggaagaag cagcagctgt ccataggacc   1320

ctgcaagtcg ctacctaatt ctcccagcca ttcctccgtc tgttccgcgc aggtgtctgc   1380

cgtgcacatc agccagacaa gtaatggagg tgggagttta agcgactatt cctcctccgt   1440

tccatcgact cccagcacca gccagaagga acttcggatc gatgttcctc ccactgccaa   1500

cacgcccacg cccgttcgca agcagtctaa gcgccggtcc aacctgttca cctctcggaa   1560

agggagcgac ccagacaaag agaagaaagg cctggagagt cgtgcggaca gcattgggag   1620

cggccgagcc atcccaatta aacagggcat gctgttgaag cgaagtggca aatcgttgaa   1680

taaagagtgg aaaaagaaat atgtcaccct gtgtgacaat ggcgtgctga cctatcatcc   1740

cagtttacat gattacatgc agaatgttca tggtaaggag attgaccttc tgagaaccac   1800

tgtgaaagtc ccagggaaga ggccaccccg agccacgtca gcctgcgcac ccatctccag   1860

ccctaaaacc aatggcctat ccaaggacat gagcagttta cacatctcac ccaattcagg   1920

gaatgtcact agtgcatctg ggtctcagat ggcaagcggc atcagcctgg tctccttcaa   1980

cagccgaccc gacggcatgc accagcgctc ctactcagtc tccagtgccg accagtggag   2040

tgaggctacg gtcattgcaa actcggccat cagcagtgac acagggctgg gtgactccgt   2100

atgctccagc cccagtatct ccagcaccac cagccccaag ctcgacccgc ccccctcccc   2160

tcacgccaac agaaagaagc accgaaggaa gaaaagcact agcaacttca aagccgacgg   2220

cctgtccggc actgctgaag aacaagaaga aaattttgag tttatcattg tgtccctcac   2280

tggccaaaca tggcactttg aagccacgac gtatgaggag cgggacgcct gggtccaagc   2340

catcgagagc cagatcctgg ccagcctgca gtcgtgcgag agcagcaaga acaagtcccg   2400

gctgacgagc cagagcgagg ccatggccct gcagtcgatc cggaacatgc gcgggaactc   2460

ccactgtgtg gactgcgaga cccagaatcc caactgggcc agtttgaact tgggagccct   2520

catgtgcatc gaatgctcag ggatccaccg gaatcttggc acccaccttt cccgagtccg   2580

atctctggac ctggatgact ggccagtcga gctcatcaag gtgatgtcat ccatcgggaa   2640

cgagctagcc aacagcgtct gggaagagag cagccagggg cggacgaaac catcggtaga   2700

ctccacaagg gaagagaagg aacggtggat ccgtgccaag tacgagcaga agctcttcct   2760

ggccccgctg ccctgcacgg agctgtccct gggccagcac ctgctgcggg ccaccgccga   2820

cgaggacctg cggacggcca tcctgctgct ggcacacggc tcccgggacg aggtgaacga   2880

gacctgcggg gagggagacg gccgcacggc gctgcatctg gcctgccgca aggggaatgt   2940

ggtcctggcg cagctcctga tctggtacgg agtggacgtc acggcccgag atgcccacgg   3000

gaacacagct ctggcctacg cccggcaggc ctccagccag gagtgcatcg acgtgctgct   3060

gcagtacggc tgccccgacg agcgcttcgt gctcatggcc acccctaacc tgtccaggag   3120

aaacaataac cggaacaaca gcagtgggag ggtgcccacc atcatctgag gaacagccgt   3180

gcccgcctgc tcgccgcacc tgggacgcgg cagcctcgcc gcattctcgc tcagaagtcg   3240

cagcacgtga gtcccgtcgc atcccctccc tcttcctggt ggccacctcc ctcccgccca   3300

cccactctca ccccaaacaa aatcacaaaa cctggacatc cctcaagggg cgaagaggcg   3360

gccgggagac tgcagaagtg gctccttttc ataaactccc ctaaaccaca cacaggagag   3420

agcgacgggc ctcggccctt tgatgatagc acatggcgca ggacccttgt cctggtggca   3480

caagggatgg ggacgcgagg gggaggggag gcgaggaaca aggagaaggg gcaactttcc   3540

ttaactggca gttgagcaca tagtacattt cccctctacc aaacggaaca cttggattcc   3600

atctcttctc tgaggagctc gacggcataa atcagaagca agcacagagt ttgtcaggtt   3660

tgaagcccct atgatggtgt gtgtcaaatc agttgtagct aatctgtcca gggagaatac   3720

tggcttcatt acacttgtac agccgagttc ttcccgcatt actgctgttt aatagaacgt   3780

gattagtcat cgccgagaag aaagcatatt agccgaggag gtagtcacgc ggcacgcgcc   3840

ggtgattgcc acgatgtgat tgcaatactc ttagaagcac catattatcc cagacatgtt   3900

ctttcaagcc cttggagccc tctctaaatt cactgtcatc atttagtatc tgtttaattt   3960

ttcagtccaa agagaggaaa tcagtcgctg agtattattt gactccggtc tccttggtgc   4020

aaaaacaaaa tgggaaaaat aaataagaat aactcagaaa ctcaaaagga aaccacaaat   4080

tcagctaata atagcatttc gagtatattt cgtaaactaa ggaaatacac aaaaggctgt   4140

tttttccgac tgtaagagat atttgatgtc cttttgccga ggtggatgtg ttagtctcag   4200

gccctcctgg accacgttgc ccaagtcaca caggcttctg tgttatgtat ttagataaga   4260

tgtgtgaaaa tatatttgaa taaaagaagt tcataaatat gcattgattt ttgtacagac   4320

aaatggcacc tctcttaatt tataaattga actggatgtg aactaataat gtgcaactag   4380

ttgagataag agggttacag atcattgtac atggaaaata ttcccagcag taaacacttc   4440

cattaatgtg atctacggct tttgaaaagg agcatctcag aataagatgg tggtacaatt   4500

tgcttattaa aattgagaaa gaaaaaaaaa                                    4530


<210>  716
<211>  857
<212>  PRT
<213>  Homosapiens

<400>  716

Met Asn Tyr Gln Gln Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu 
1               5                   10                  15      


Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu 
            20                  25                  30          


Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu 
        35                  40                  45              


His Val Ile Ala Ile Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Thr 
    50                  55                  60                  


Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Thr Gly Thr Tyr 
                85                  90                  95      


Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val 
            100                 105                 110         


Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Gln Phe Ala Met Trp Val Asp Ala Val Ile Phe Val Phe 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ile Ser Phe Gln Thr Val Tyr His Tyr Tyr Ser 
145                 150                 155                 160 


Arg Met Ala Asn Tyr Arg Asn Thr Ser Glu Ile Pro Leu Val Leu Val 
                165                 170                 175     


Gly Thr Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp 
            180                 185                 190         


Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Thr Tyr Tyr 
        195                 200                 205             


Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp 
    210                 215                 220                 


Val Ala Gln Lys Ile Val Ala Thr Arg Lys Lys Gln Gln Leu Ser Ile 
225                 230                 235                 240 


Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 
                245                 250                 255     


Ser Ala Gln Val Ser Ala Val His Ile Ser Gln Thr Ser Asn Gly Gly 
            260                 265                 270         


Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Thr Pro Ser Thr 
        275                 280                 285             


Ser Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Thr Ala Asn Thr Pro 
    290                 295                 300                 


Thr Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Thr Ser 
305                 310                 315                 320 


Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg 
                325                 330                 335     


Ala Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Met 
            340                 345                 350         


Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys 
        355                 360                 365             


Tyr Val Thr Leu Cys Asp Asn Gly Val Leu Thr Tyr His Pro Ser Leu 
    370                 375                 380                 


His Asp Tyr Met Gln Asn Val His Gly Lys Glu Ile Asp Leu Leu Arg 
385                 390                 395                 400 


Thr Thr Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Thr Ser Ala 
                405                 410                 415     


Cys Ala Pro Ile Ser Ser Pro Lys Thr Asn Gly Leu Ser Lys Asp Met 
            420                 425                 430         


Ser Ser Leu His Ile Ser Pro Asn Ser Gly Asn Val Thr Ser Ala Ser 
        435                 440                 445             


Gly Ser Gln Met Ala Ser Gly Ile Ser Leu Val Ser Phe Asn Ser Arg 
    450                 455                 460                 


Pro Asp Gly Met His Gln Arg Ser Tyr Ser Val Ser Ser Ala Asp Gln 
465                 470                 475                 480 


Trp Ser Glu Ala Thr Val Ile Ala Asn Ser Ala Ile Ser Ser Asp Thr 
                485                 490                 495     


Gly Leu Gly Asp Ser Val Cys Ser Ser Pro Ser Ile Ser Ser Thr Thr 
            500                 505                 510         


Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His Ala Asn Arg Lys Lys 
        515                 520                 525             


His Arg Arg Lys Lys Ser Thr Ser Asn Phe Lys Ala Asp Gly Leu Ser 
    530                 535                 540                 


Gly Thr Ala Glu Glu Gln Glu Glu Asn Phe Glu Phe Ile Ile Val Ser 
545                 550                 555                 560 


Leu Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr Glu Glu Arg 
                565                 570                 575     


Asp Ala Trp Val Gln Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln 
            580                 585                 590         


Ser Cys Glu Ser Ser Lys Asn Lys Ser Arg Leu Thr Ser Gln Ser Glu 
        595                 600                 605             


Ala Met Ala Leu Gln Ser Ile Arg Asn Met Arg Gly Asn Ser His Cys 
    610                 615                 620                 


Val Asp Cys Glu Thr Gln Asn Pro Asn Trp Ala Ser Leu Asn Leu Gly 
625                 630                 635                 640 


Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Asn Leu Gly Thr 
                645                 650                 655     


His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro Val Glu 
            660                 665                 670         


Leu Ile Lys Val Met Ser Ser Ile Gly Asn Glu Leu Ala Asn Ser Val 
        675                 680                 685             


Trp Glu Glu Ser Ser Gln Gly Arg Thr Lys Pro Ser Val Asp Ser Thr 
    690                 695                 700                 


Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu 
705                 710                 715                 720 


Phe Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly Gln His Leu 
                725                 730                 735     


Leu Arg Ala Thr Ala Asp Glu Asp Leu Arg Thr Ala Ile Leu Leu Leu 
            740                 745                 750         


Ala His Gly Ser Arg Asp Glu Val Asn Glu Thr Cys Gly Glu Gly Asp 
        755                 760                 765             


Gly Arg Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val Val Leu 
    770                 775                 780                 


Ala Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Thr Ala Arg Asp Ala 
785                 790                 795                 800 


His Gly Asn Thr Ala Leu Ala Tyr Ala Arg Gln Ala Ser Ser Gln Glu 
                805                 810                 815     


Cys Ile Asp Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu Arg Phe Val 
            820                 825                 830         


Leu Met Ala Thr Pro Asn Leu Ser Arg Arg Asn Asn Asn Arg Asn Asn 
        835                 840                 845             


Ser Ser Gly Arg Val Pro Thr Ile Ile 
    850                 855         


<210>  717
<211>  4371
<212>  DNA
<213>  Homosapiens

<400>  717
gctcggagcg ggctccgcgg cttgcaaggc gcctgcgact cggtcccagg tcggcgggcg     60

gcgcacggcg ggctcgcgcg ggggccccgg cgcgccgggc ggcgcagtac gcagcgcgcg    120

gacccacgcc acggccagga gcccagagca gcgcggccac actgcccagg ggtcggccct    180

cggccccggc gctcggagcg cggcggctgc ctgggcttta atggctgctc cgcggagcag    240

cgcctagggc tggaaggcgg ctgcggctca ggaagtcacc cgagcaagcc tccttcgggg    300

ccggccgcac ccgccgcggc gcgctccatg ggggcgcgct ccccccgggc ggcccgctga    360

cccgggacgc cggggcccgc tcgctcgccg gccgcgcgtc ccggccatga actgagcccg    420

cgggccagcc ccgcgcctgc tccgcccgcg cctttcttct cgcgcctcct ccgcccgccg    480

ccggcgggcc cggctccccg ggggctgcgg cgccccgggc tcggcggccc gcgggccccg    540

gggcgcgggg cggcggcggc ggggggcgcg cggctccggg cgcggcgcct gcaccatgaa    600

ctaccagcag cagctggcca actcggctgc catccgggcc gagatccagc gcttcgagtc    660

ggtccacccc aacatctact ccatctacga gctgctggag cgcgtggagg agccggtgct    720

gcagaaccag atccgggagc acgtcatcgc catcgaagat gccttcgtga acagccagga    780

atggacgctg agtcgatctg tcccggagct caaagtggga attgtgggta acttggccag    840

cggcaagtct gccctggtgc accggtacct gacgggcaca tatgtccagg aggagtctcc    900

ggaaggtggc aggttcaaga aagagattgt cgttgatgga cagagctatc tgctgctgat    960

cagagatgaa gggggccccc cggaggcgca gtttgccatg tgggtggacg ctgttatatt   1020

tgtcttcagc ttggaggatg aaataagttt ccagaccgtt taccactact acagtcgaat   1080

ggccaactat cggaacacga gcgagattcc tctggttctg gtgggaaccc aggatgccat   1140

aagttctgct aacccgaggg tcatcgatga cgccagggcg aggaagctct ccaacgacct   1200

gaaacggtgc acgtactacg agacgtgtgc tacatacggg ctgaatgtgg agagggtctt   1260

ccaggacgtt gcccagaaga ttgttgccac aaggaagaag cagcagctgt ccataggacc   1320

ctgcaagtcg ctacctaatt ctcccagcca ttcctccgtc tgttccgcgc aggtgtctgc   1380

cgtgcacatc agccagacaa gtaatggagg tgggagttta agcgactatt cctcctccgt   1440

tccatcgact cccagcacca gccagaagga acttcggatc gatgttcctc ccactgccaa   1500

cacgcccacg cccgttcgca agcagtctaa gcgccggtcc aacctgttca cctctcggaa   1560

agggagcgac ccagacaaag agaagaaagg cctggagagt cgtgcggaca gcattgggag   1620

cggccgagcc atcccaatta aacagggcat gctgttgaag cgaagtggca aatcgttgaa   1680

taaagagtgg aaaaagaaat atgtcaccct gtgtgacaat ggcgtgctga cctatcatcc   1740

cagtttacat gattacatgc agaatgttca tggtaaggag attgaccttc tgagaaccac   1800

tgtgaaagtc ccagggaaga ggccaccccg agccacgtca gcctgcgcac ccatctccag   1860

ccctaaaacc aatggcctat ccaaggacat gagcagttta cacatctcac ccaattcaga   1920

cacagggctg ggtgactccg tatgctccag ccccagtatc tccagcacca ccagccccaa   1980

gctcgacccg cccccctccc ctcacgccaa cagaaagaag caccgaagga agaaaagcac   2040

tagcaacttc aaagccgacg gcctgtccgg cactgctgaa gaacaagaag aaaattttga   2100

gtttatcatt gtgtccctca ctggccaaac atggcacttt gaagccacga cgtatgagga   2160

gcgggacgcc tgggtccaag ccatcgagag ccagatcctg gccagcctgc agtcgtgcga   2220

gagcagcaag aacaagtccc ggctgacgag ccagagcgag gccatggccc tgcagtcgat   2280

ccggaacatg cgcgggaact cccactgtgt ggactgcgag acccagaatc ccaactgggc   2340

cagtttgaac ttgggagccc tcatgtgcat cgaatgctca gggatccacc ggaatcttgg   2400

cacccacctt tcccgagtcc gatctctgga cctggatgac tggccagtcg agctcatcaa   2460

ggtgatgtca tccatcggga acgagctagc caacagcgtc tgggaagaga gcagccaggg   2520

gcggacgaaa ccatcggtag actccacaag ggaagagaag gaacggtgga tccgtgccaa   2580

gtacgagcag aagctcttcc tggccccgct gccctgcacg gagctgtccc tgggccagca   2640

cctgctgcgg gccaccgccg acgaggacct gcggacggcc atcctgctgc tggcacacgg   2700

ctcccgggac gaggtgaacg agacctgcgg ggagggagac ggccgcacgg cgctgcatct   2760

ggcctgccgc aaggggaatg tggtcctggc gcagctcctg atctggtacg gagtggacgt   2820

cacggcccga gatgcccacg ggaacacagc tctggcctac gcccggcagg cctccagcca   2880

ggagtgcatc gacgtgctgc tgcagtacgg ctgccccgac gagcgcttcg tgctcatggc   2940

cacccctaac ctgtccagga gaaacaataa ccggaacaac agcagtggga gggtgcccac   3000

catcatctga ggaacagccg tgcccgcctg ctcgccgcac ctgggacgcg gcagcctcgc   3060

cgcattctcg ctcagaagtc gcagcacgtg agtcccgtcg catcccctcc ctcttcctgg   3120

tggccacctc cctcccgccc acccactctc accccaaaca aaatcacaaa acctggacat   3180

ccctcaaggg gcgaagaggc ggccgggaga ctgcagaagt ggctcctttt cataaactcc   3240

cctaaaccac acacaggaga gagcgacggg cctcggccct ttgatgatag cacatggcgc   3300

aggacccttg tcctggtggc acaagggatg gggacgcgag ggggagggga ggcgaggaac   3360

aaggagaagg ggcaactttc cttaactggc agttgagcac atagtacatt tcccctctac   3420

caaacggaac acttggattc catctcttct ctgaggagct cgacggcata aatcagaagc   3480

aagcacagag tttgtcaggt ttgaagcccc tatgatggtg tgtgtcaaat cagttgtagc   3540

taatctgtcc agggagaata ctggcttcat tacacttgta cagccgagtt cttcccgcat   3600

tactgctgtt taatagaacg tgattagtca tcgccgagaa gaaagcatat tagccgagga   3660

ggtagtcacg cggcacgcgc cggtgattgc cacgatgtga ttgcaatact cttagaagca   3720

ccatattatc ccagacatgt tctttcaagc ccttggagcc ctctctaaat tcactgtcat   3780

catttagtat ctgtttaatt tttcagtcca aagagaggaa atcagtcgct gagtattatt   3840

tgactccggt ctccttggtg caaaaacaaa atgggaaaaa taaataagaa taactcagaa   3900

actcaaaagg aaaccacaaa ttcagctaat aatagcattt cgagtatatt tcgtaaacta   3960

aggaaataca caaaaggctg ttttttccga ctgtaagaga tatttgatgt ccttttgccg   4020

aggtggatgt gttagtctca ggccctcctg gaccacgttg cccaagtcac acaggcttct   4080

gtgttatgta tttagataag atgtgtgaaa atatatttga ataaaagaag ttcataaata   4140

tgcattgatt tttgtacaga caaatggcac ctctcttaat ttataaattg aactggatgt   4200

gaactaataa tgtgcaacta gttgagataa gagggttaca gatcattgta catggaaaat   4260

attcccagca gtaaacactt ccattaatgt gatctacggc ttttgaaaag gagcatctca   4320

gaataagatg gtggtacaat ttgcttatta aaattgagaa agaaaaaaaa a            4371


<210>  718
<211>  804
<212>  PRT
<213>  Homosapiens

<400>  718

Met Asn Tyr Gln Gln Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu 
1               5                   10                  15      


Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu 
            20                  25                  30          


Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu 
        35                  40                  45              


His Val Ile Ala Ile Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Thr 
    50                  55                  60                  


Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Thr Gly Thr Tyr 
                85                  90                  95      


Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val 
            100                 105                 110         


Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Gln Phe Ala Met Trp Val Asp Ala Val Ile Phe Val Phe 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ile Ser Phe Gln Thr Val Tyr His Tyr Tyr Ser 
145                 150                 155                 160 


Arg Met Ala Asn Tyr Arg Asn Thr Ser Glu Ile Pro Leu Val Leu Val 
                165                 170                 175     


Gly Thr Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp 
            180                 185                 190         


Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Thr Tyr Tyr 
        195                 200                 205             


Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp 
    210                 215                 220                 


Val Ala Gln Lys Ile Val Ala Thr Arg Lys Lys Gln Gln Leu Ser Ile 
225                 230                 235                 240 


Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 
                245                 250                 255     


Ser Ala Gln Val Ser Ala Val His Ile Ser Gln Thr Ser Asn Gly Gly 
            260                 265                 270         


Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Thr Pro Ser Thr 
        275                 280                 285             


Ser Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Thr Ala Asn Thr Pro 
    290                 295                 300                 


Thr Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Thr Ser 
305                 310                 315                 320 


Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg 
                325                 330                 335     


Ala Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Met 
            340                 345                 350         


Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys 
        355                 360                 365             


Tyr Val Thr Leu Cys Asp Asn Gly Val Leu Thr Tyr His Pro Ser Leu 
    370                 375                 380                 


His Asp Tyr Met Gln Asn Val His Gly Lys Glu Ile Asp Leu Leu Arg 
385                 390                 395                 400 


Thr Thr Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Thr Ser Ala 
                405                 410                 415     


Cys Ala Pro Ile Ser Ser Pro Lys Thr Asn Gly Leu Ser Lys Asp Met 
            420                 425                 430         


Ser Ser Leu His Ile Ser Pro Asn Ser Asp Thr Gly Leu Gly Asp Ser 
        435                 440                 445             


Val Cys Ser Ser Pro Ser Ile Ser Ser Thr Thr Ser Pro Lys Leu Asp 
    450                 455                 460                 


Pro Pro Pro Ser Pro His Ala Asn Arg Lys Lys His Arg Arg Lys Lys 
465                 470                 475                 480 


Ser Thr Ser Asn Phe Lys Ala Asp Gly Leu Ser Gly Thr Ala Glu Glu 
                485                 490                 495     


Gln Glu Glu Asn Phe Glu Phe Ile Ile Val Ser Leu Thr Gly Gln Thr 
            500                 505                 510         


Trp His Phe Glu Ala Thr Thr Tyr Glu Glu Arg Asp Ala Trp Val Gln 
        515                 520                 525             


Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser 
    530                 535                 540                 


Lys Asn Lys Ser Arg Leu Thr Ser Gln Ser Glu Ala Met Ala Leu Gln 
545                 550                 555                 560 


Ser Ile Arg Asn Met Arg Gly Asn Ser His Cys Val Asp Cys Glu Thr 
                565                 570                 575     


Gln Asn Pro Asn Trp Ala Ser Leu Asn Leu Gly Ala Leu Met Cys Ile 
            580                 585                 590         


Glu Cys Ser Gly Ile His Arg Asn Leu Gly Thr His Leu Ser Arg Val 
        595                 600                 605             


Arg Ser Leu Asp Leu Asp Asp Trp Pro Val Glu Leu Ile Lys Val Met 
    610                 615                 620                 


Ser Ser Ile Gly Asn Glu Leu Ala Asn Ser Val Trp Glu Glu Ser Ser 
625                 630                 635                 640 


Gln Gly Arg Thr Lys Pro Ser Val Asp Ser Thr Arg Glu Glu Lys Glu 
                645                 650                 655     


Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu Phe Leu Ala Pro Leu 
            660                 665                 670         


Pro Cys Thr Glu Leu Ser Leu Gly Gln His Leu Leu Arg Ala Thr Ala 
        675                 680                 685             


Asp Glu Asp Leu Arg Thr Ala Ile Leu Leu Leu Ala His Gly Ser Arg 
    690                 695                 700                 


Asp Glu Val Asn Glu Thr Cys Gly Glu Gly Asp Gly Arg Thr Ala Leu 
705                 710                 715                 720 


His Leu Ala Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu Ile 
                725                 730                 735     


Trp Tyr Gly Val Asp Val Thr Ala Arg Asp Ala His Gly Asn Thr Ala 
            740                 745                 750         


Leu Ala Tyr Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asp Val Leu 
        755                 760                 765             


Leu Gln Tyr Gly Cys Pro Asp Glu Arg Phe Val Leu Met Ala Thr Pro 
    770                 775                 780                 


Asn Leu Ser Arg Arg Asn Asn Asn Arg Asn Asn Ser Ser Gly Arg Val 
785                 790                 795                 800 


Pro Thr Ile Ile 
                


<210>  719
<211>  3700
<212>  DNA
<213>  Homosapiens

<400>  719
gtcactgtct tgggctgtgt gctgacggga gccagggcct tgtaaggccc agaccctcct     60

ccttctctcc cgtattagtc aaggttctcc agagaaatgg agttagagat gcattgctat    120

aagaaatgga atgggctcgc atgattacag aggctgaggg gtcctacacc ctgtcgtctg    180

caagctggaa aggcaggaga gtctgtgctg cagccctagc cagagcctgg aggcccgaga    240

accaggcacg ccgacgacag cacacttcca gcctgagagc aagagaaggt cagtgttcca    300

gctccagcag gcaggcagag ggagggttct ctctccacct ttgtgttcta ctcaggtctt    360

caatgggttg gatgaggccc atccacattg cgagggcgtc tgcttcactg aatccaccat    420

cgtacctgct tctcttggat gccgtccgat tgcagagacg ctgttccctt gagggttcct    480

gccccaccgt gtgtgctggt gctaggatgt ctgccctggt ccagccctgc acccctgagt    540

cagaggctct tactctgggt tcaattaaga aggttatttg gcccccacac aaagctaaga    600

ctttcacctt ggcatttgtt aggaattctt tcctgaagtt ggacagtttg gccatgttca    660

agcctctgaa ttcttccata gaattgtctt ctggaaatca tgccacagta atttaagtct    720

ccccggctgt atgtgtgagg acttcttacc ctcttgggca tggaggggtt agcatgtttg    780

gtagccattc tagtcatagt aggttgacag ttgagtgttt cctagatctt tccaagtaga    840

ccagcatgac tatggaagag gccctgaagg tcccaccccg acacgccagt ccgaagggcc    900

cttgcctggg caccctgcac cttcccctgg acctgctgat gcgcctggct gggggaatgc    960

gggccttcgc gttggttcca cctccagctt ccatgactgt ggagttctgc agtgggttca   1020

ttgagaaagt ggtggtgaga ccagggtatc tgagaggagt ggtcggcagg gagatgagac   1080

aagtgtggag accaggcaga tggaaggcgc atgtctggag ggtgtgagag ctgccaggtg   1140

ggtgtctgca gggtcttgca gagtcgctca gccgcaggtg gggcggctct ggagacccta   1200

tcagcacatt ccagagagtg gcagacccca cggccaggca tggactgatg agcaggactg   1260

tcctccactg tccagacaac agcacagatg aaacccagga gcgcctggga cggtgctgtg   1320

agccctgcac atccacggag tctctcagat gaaaccacac gggtgtcaca gtgacgctct   1380

ctcccctcag aggctgccga cccctcgctg ggctgctgga ctgctcaggg ccggcccttg   1440

aagcctggag ggagccatgg gtctgtgtgt acacatgtgt gtgcccgtga gtgagtctat   1500

gtgtgatctc tgaaaatgaa gcttccacat taccaatgcc tggagaatcc agaactggga   1560

ctcccaggta actgagggcc tgggtcccaa agctggtggc tgaagctggc tgctccgagg   1620

catgcgtggc aggaaggggt catcaggagg gccacccaag gccccgggca cctctgatgg   1680

gtttccagag tccctgccct cacgagaggg aagtcagttg gagaatgggg tgctgaagtc   1740

tcgagagaaa ggtgtccttg actcggggtc cagagtaagc agcttctgcc ccccatatca   1800

cgtggctagt ggcttgtcct gactgtgccc cacgtgtcat ggcaaagttt cgacacccac   1860

tttggagatg tcttgacaga ggccagcgtc aggctcccgt tcttccacac gctggaagct   1920

gctgcacagc gggctcagag cctgggctca ggaggcatcc cggttactgt tgctgtatcc   1980

tggagggtgg catctcctgg gagctgtggt ccgagcccct tgcaacagcg gggccaggag   2040

aaggctggtt gctgggtgca tcctgttctt ggggttccac ctgctgtatc catctcccgg   2100

gggattttcc gtcgccgtcc ttggttccag cacatgccct gagtggtaat gccgattcct   2160

gcctgtgctg ccgacttggt gcggggagcc tgtggctgct ctgtcaggtg gttggccccg   2220

atggctccat gggtggcccc cgcccaggca tctcatggag ggactctgcc tacgtcactg   2280

gccgccagtc ctgggggaca ccgtgtgcat ttgcacatga accatgatgg gaacctgggg   2340

gacgggtctc aggctgagaa aggttcccct gggcttcaag gtaaatcata aagcgaggta   2400

atttcctata agtgtcagag gacactgtaa ctgtcccttc tgagcaggac attgttgtgg   2460

ttgtctgtct tcccttttgt cttctgcctg tgggattatc tagattctga gcaggtaaat   2520

tgtttcaggc tctggccttc tcagagcctt tctgtggctg taggttgtgg ggagggcacc   2580

atggtagttg cccctgcttc attcactcag agccactgac aggggccccc caacctgctc   2640

ggagccctcc aggggcaggc actgtccctg ctgcccccct gctgccctga acatctcccc   2700

agccccacag ctgacccacc ctttcagggt aacagtgcag ctgcgggggc agccccctcc   2760

agcccttcct tggtcagcct ccctgctgct ggcccttcct ggagacgtga tttgccctag   2820

aagtggcagg tgtgtgtggc tcatgccctc actgtaaggc tgtgccaagg cagtgccacc   2880

ttgggaaaaa tcaaaacccc ataccagctc ctcccagtcc atgccagcac acaccctggc   2940

tcctcagaac cccccacaga agcaggcaag gaatcaaaaa ctcaagtctg caggaagcca   3000

ggcagggatg gaggaggggt atactgtcac aggtgagagg gtcccagaag cctttctgga   3060

ggaggtgact tcaggctgga tttggagggg caacttaaca agcagacagg tgggtggaga   3120

cgctccagca gaggaaatgg catggagtgt ccaggagccc acgaatcagc tggcattgtt   3180

gaatcatgga gaacgcagag acggtctcag aagtcggccg gagcctgagt cattgggcca   3240

cgcggcttca gtccttcctt gcagcctgtg gggagtctca ggggaattct gaggaggaaa   3300

gggggatgct catgataggt atttattgtt tttgtttgtt tgtttttaat cacttatttt   3360

cacaagtgta atcgaagcac ctggttgtga gtccaggaga gtaaaacatt tagccctcgc   3420

ccctcccatc catcacggat tttctgacgc ctgcagcagg gttcctgcca aaggaaaacc   3480

catttatagt catatacttc cgtgaacctt tgatataacc cagttatgta tctagaaacc   3540

tgccttttca aaaatattaa cctgtctata aatgtagtaa atgttatata aaatgcaatc   3600

atgtttaaga agttaactat tgttatatta attcgagttg aacaattcaa attctcaact   3660

tcatttataa acatagttaa ttaaattcct ttatgcatat                         3700


<210>  720
<211>  196
<212>  PRT
<213>  Homosapiens

<400>  720

Met Glu Trp Ala Arg Met Ile Thr Glu Ala Glu Gly Ser Tyr Thr Leu 
1               5                   10                  15      


Ser Ser Ala Ser Trp Lys Gly Arg Arg Val Cys Ala Ala Ala Leu Ala 
            20                  25                  30          


Arg Ala Trp Arg Pro Glu Asn Gln Ala Arg Arg Arg Gln His Thr Ser 
        35                  40                  45              


Ser Leu Arg Ala Arg Glu Gly Gln Cys Ser Ser Ser Ser Arg Gln Ala 
    50                  55                  60                  


Glu Gly Gly Phe Ser Leu His Leu Cys Val Leu Leu Arg Ser Ser Met 
65                  70                  75                  80  


Gly Trp Met Arg Pro Ile His Ile Ala Arg Ala Ser Ala Ser Leu Asn 
                85                  90                  95      


Pro Pro Ser Tyr Leu Leu Leu Leu Asp Ala Val Arg Leu Gln Arg Arg 
            100                 105                 110         


Cys Ser Leu Glu Gly Ser Cys Pro Thr Val Cys Ala Gly Ala Arg Met 
        115                 120                 125             


Ser Ala Leu Val Gln Pro Cys Thr Pro Glu Ser Glu Ala Leu Thr Leu 
    130                 135                 140                 


Gly Ser Ile Lys Lys Val Ile Trp Pro Pro His Lys Ala Lys Thr Phe 
145                 150                 155                 160 


Thr Leu Ala Phe Val Arg Asn Ser Phe Leu Lys Leu Asp Ser Leu Ala 
                165                 170                 175     


Met Phe Lys Pro Leu Asn Ser Ser Ile Glu Leu Ser Ser Gly Asn His 
            180                 185                 190         


Ala Thr Val Ile 
        195     


<210>  721
<211>  2367
<212>  DNA
<213>  Homosapiens

<400>  721
agtacccacg gaaaacttgt ttaccttgtc accatgagta aaagttaatt cccactcctg     60

aagagagcaa accaactctg aaagagagtg aaaatgcaga caagacagtt atcagataat    120

ggctatctgg acgagagatt ctttcgtttg acagcagttt ggttgttggg agttccagtt    180

cagctcctgc acagttgctc tgtacaaatc ctcctccata tttgcttaga gaaaacgtgt    240

tgccatccca tcatgaagga agctgcctga gagtttttaa ccattacagc cgtgatgatg    300

aaagagtgaa gaaccgcctc taagttaaaa agtgcaccca gagataaggt tcgttctcaa    360

tgccctgccg ctgcttctca tcgcatggcc accgcatttc tcaggccagg cacattgagc    420

attggtcctg tgcctgacgc tatgctagat gctggggttg cagccacgag catagacacg    480

acagacacgg tcctcgccat cttctgttga gtactggtcg gaacaagagg atcgtctgta    540

gacaggctac agattgtttt agattgaagt ttcctgtcat gttcactcat ctttaaatcc    600

tcatagtgaa aaggatatga tcatcgtggc gcatgtatta ctcatccttt tgggggccac    660

tgagatactg caagctgact tacttcctga tgaaaagatt tcacttctcc cacctgtcaa    720

tttcaccatt aaagttactg gtttggctca agttctttta caatggaaac caaatcctga    780

tcaagagcaa aggaatgtta atctagaata tcaagtgaaa ataaacgctc caaaagaaga    840

tgactatgaa accagaatca ctgaaagcaa atgtgtaacc atcctccaca aaggcttttc    900

agcaagtgtg cggaccatcc tgcagaacga ccactcacta ctggccagca gctgggcttc    960

tgctgaactt catgccccac cagggtctcc tggaacctca attgtgaatt taacttgcac   1020

cacaaacact acagaagaca attattcacg tttaaggtca taccaagttt cccttcactg   1080

cacctggctt gttggcacag atgcccctga ggacacgcag tattttctct actataggta   1140

tggctcttgg actgaagaat gccaagaata cagcaaagac acactgggga gaaatatcgc   1200

atgctggttt cccaggactt ttatcctcag caaagggcgt gactggcttg cggtgcttgt   1260

taacggctcc agcaagcact ctgctatcag gccctttgat cagctgtttg cccttcacgc   1320

cattgatcaa ataaatcctc cactgaatgt cacagcagag attgaaggaa ctcgtctctc   1380

tatccaatgg gagaaaccag tgtctgcttt tccaatccat tgctttgatt atgaagtaaa   1440

aatacacaat acaaggaatg gatatttgca gatagaaaaa ttgatgacca atgcattcat   1500

ctcaataatt gatgatcttt ctaagtacga tgttcaagtg agagcagcag tgagctccat   1560

gtgcagagag gcagggctct ggagtgagtg gagccaacct atttatgtgg gaaatgatga   1620

acacaagccc ttgagagagt ggtttgtcat tgtgattatg gcaaccatct gcttcatctt   1680

gttaattctc tcgcttatct gtaaaatatg tcatttatgg atcaagttgt ttccaccaat   1740

tccagcacca aaaagtaata tcaaagatct ctttgtaacc actaactatg agaaagctgg   1800

gtccagtgag acggaaattg aagtcatctg ttatatagag aagcctggag ttgagaccct   1860

ggaggattct gtgttttgac tgtcactttg gcatcctctg atgaactcac acatgcctca   1920

gtgcctcagt gaaaagaaca gggatgctgg ctcttggcta agaggtgttc agaatttagg   1980

caacactcaa tttacctgcg aagcaataca cccagacaca ccagtcttgt atctcttaaa   2040

agtatggatg cttcatccaa atcgcctcac ctacagcagg gaagttgact catccaagca   2100

ttttgccatg ttttttctcc ccatgccgta cagggtagca cctcctcacc tgccaatctt   2160

tgcaatttgc ttgactcacc tcagactttt cattcacaac agacagcttt taaggctaac   2220

gtccagctgt atttacttct ggctgtgccc gtttggctgt ttaagctgcc aattgtagca   2280

ctcagctacc atctgaggaa gaaagcattt tgcatcagcc tggagtgaac catgaacttg   2340

gattcaagac tgtcttttct atagcaa                                       2367


<210>  722
<211>  420
<212>  PRT
<213>  Homosapiens

<400>  722

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  723
<211>  2024
<212>  DNA
<213>  Homosapiens

<400>  723
agtacccacg gaaaacttgt ttaccttgtc accatgagta aaagttaatt cccactcctg     60

aagagagcaa accaactctg aaagagagtg aaaatgcaga caagacagtt atcagataat    120

ggctatctgg acgagagatt ctttcgtttg acagcagttt ggttgttggg agttccagtt    180

cagctcctgc acagttgctc tgtacaaatc ctcctccata tttgcttaga gaaaacgtgt    240

tgccatccca tcatgaagga agctgcctga gagtttttaa ccattacagc cgtgatgatg    300

aaagagtgaa gaaccgcctc taagttaaaa agtgcaccca gagataaggt tcgttctcaa    360

tgccctgccg ctgcttctca tcgcatggcc accgcatttc tcaggccagg cacattgagc    420

attggtcctg tgcctgacgc tatgctagat gctggggttg cagccacgag catagacacg    480

acagacacgg tcctcgccat cttctgttga gtactggtcg gaacaagagg atcgtctgta    540

gacaggctac agattgtttt agattgaagt ttcctgtcat gttcactcat ctttaaatcc    600

tcatagtgaa aaggatatga tcatcgtggc gcatgtatta ctcatccttt tgggggccac    660

tgagatactg caagctgact tacttcctga tgaaaagatt tcacttctcc cacctgtcaa    720

tttcaccatt aaagttactg gtttggctca agttctttta caatggaaac caaatcctga    780

tcaagagcaa aggaatgtta atctagaata tcaagtgaaa ataaacgctc caaaagaaga    840

tgactatgaa accagaatca ctgaaagcaa atgtgtaacc atcctccaca aaggcttttc    900

agcaagtgtg cggaccatcc tgcagaacga ccactcacta ctggccagca gctgggcttc    960

tgctgaactt catgccccac cagggtctcc tggaacctca attgtgaatt taacttgcac   1020

cacaaacact acagaagaca attattcacg tttaaggtca taccaagttt cccttcactg   1080

cacctggctt gttggcacag atgcccctga ggacacgcag tattttctct actataggta   1140

tggctcttgg actgaagaat gccaagaata cagcaaagac acactgggga gaaatatcgc   1200

atgctggttt cccaggactt ttatcctcag caaagggcgt gactggcttg cggtgcttgt   1260

taacggctcc agcaagcact ctgctatcag gccctttgat cagctgtttg cccttcacgc   1320

cattgatcaa ataaatcctc cactgaatgt cacagcagag attgaaggaa ctcgtctctc   1380

tatccaatgg gagaaaccag tgtctgcttt tccaatccat tgctttgatt atgaagtaaa   1440

aatacacaat acaaggaatg gatatttgca gatagaaaaa ttgatgacca atgcattcat   1500

ctcaataatt gatgatcttt ctaagtacga tgttcaagtg agagcagcag tgagctccat   1560

gtgcagagag gcagggctct ggagtgagtg gagccaacct atttatgtgg gtaagtagct   1620

tatgtttatt ttacattggc agccttcctt gtgatcaaaa aaggtaatcc cagaaacgta   1680

cccgttcact cgtgggtctt aaaatggttt catatctcta ttgtgactaa ttttctctcg   1740

gtctactgcc ttttcaatca ggaatagatt tgccatgaag ccagtgaagt ttttaagtgt   1800

ctaggcttct cattagcgcc aactctccta gacctggtgc ctgttttttt tccaagtttt   1860

gtttctactt ctatccattt tttaaattaa actttttatt ttgaaataat tatcacactc   1920

acaagctgtg ggaagaaata atagagatcc tgtgtctctt tcatccagtt ttcctcaagg   1980

gtaacatctt acaaaactat agtacaatag tggaatagaa tatt                    2024


<210>  724
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  724

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Lys 
                325                 330             


<210>  725
<211>  1694
<212>  DNA
<213>  Homosapiens

<400>  725
agtacccacg gaaaacttgt ttaccttgtc accatgagta aaagttaatt cccactcctg     60

aagagagcaa accaactctg aaagagagtg aaaatgcaga caagacagtt atcagataat    120

ggctatctgg acgagagatt ctttcgtttg acagcagttt ggttgttggg agttccagtt    180

cagctcctgc acagttgctc tgtacaaatc ctcctccata tttgcttaga gaaaacgtgt    240

tgccatccca tcatgaagga agctgcctga gagtttttaa ccattacagc cgtgatgatg    300

aaagagtgaa gaaccgcctc taagttaaaa agtgcaccca gagataaggt tcgttctcaa    360

tgccctgccg ctgcttctca tcgcatggcc accgcatttc tcaggccagg cacattgagc    420

attggtcctg tgcctgacgc tatgctagat gctggggttg cagccacgag catagacacg    480

acagacacgg tcctcgccat cttctgttga gtactggtcg gaacaagagg atcgtctgta    540

gacaggctac agattgtttt agattgaagt ttcctgtcat gttcactcat ctttaaatcc    600

tcatagtgaa aaggatatga tcatcgtggc gcatgtatta ctcatccttt tgggggccac    660

tgagatactg caagctgact tacttcctga tgaaaagatt tcacttctcc cacctgtcaa    720

tttcaccatt aaagttactg gtttggctca agttctttta caatggaaac caaatcctga    780

tcaagagcaa aggaatgtta atctagaata tcaagtgaaa ataaacgctc caaaagaaga    840

tgactatgaa accagaatca ctgaaagcaa atgtgtaacc atcctccaca aaggcttttc    900

agcaagtgtg cggaccatcc tgcagaacga ccactcacta ctggccagca gctgggcttc    960

tgctgaactt catgccccac cagggtctcc tggaacctca attgtgaatt taacttgcac   1020

cacaaacact acagaagaca attattcacg tttaaggtca taccaagttt cccttcactg   1080

cacctggctt gttggcacag atgcccctga ggacacgcag tattttctct actataggta   1140

tggctcttgg actgaagaat gccaagaata cagcaaagac acactgggga gaaatatcgc   1200

atgctggttt cccaggactt ttatcctcag caaagggcgt gactggcttg cggtgcttgt   1260

taacggctcc agcaagcact ctgctatcag gccctttgat cagctgtttg cccttcacgc   1320

cattgatcaa ataaatcctc cactgaatgt cacagcagag attgaaggaa ctcgtctctc   1380

tatccaatgg gagaaaccag tgtctgcttt tccaatccat tgctttgatt atgaagtaaa   1440

aatacacaat acaaggaatg gatatttgca gatagaaaaa ttgatgacca atgcattcat   1500

ctcaataatt gatgatcttt ctaagtacga tgttcaagtg agagcagcag tgagctccat   1560

gtgcagagag gcagggctct ggagtgagtg gagccaacct atttatgtgg ggttctcaag   1620

ataaaggaga taacatccag ctttcctgcc ccacaccgta tctgaaataa aaacaacagc   1680

agggatagca gatt                                                     1694


<210>  726
<211>  335
<212>  PRT
<213>  Homosapiens

<400>  726

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Phe Ser Arg 
                325                 330                 335 


<210>  727
<211>  2299
<212>  DNA
<213>  Homosapiens

<400>  727
agtacccacg gaaaacttgt ttaccttgtc accatgagta aaagttaatt cccactcctg     60

aagagagcaa accaactctg aaagagagtg aaaatgcaga caagacagtt atcagataat    120

ggctatctgg acgagagatt ctttcgtttg acagcagttt ggttgttggg agttccagtt    180

cagctcctgc acagttgctc tgtacaaatc ctcctccata tttgcttaga gaaaacgtgt    240

tgccatccca tcatgaagga agctgcctga gagtttttaa ccattacagc cgtgatgatg    300

aaagagtgaa gaaccgcctc taagttaaaa agtgcaccca gagataaggt tcgttctcaa    360

tgccctgccg ctgcttctca tcgcatggcc accgcatttc tcaggccagg cacattgagc    420

attggtcctg tgcctgacgc tatgctagat gctggggttg cagccacgag catagacacg    480

acagacacgg tcctcgccat cttctgttga gtactggtcg gaacaagagg atcgtctgta    540

gacaggatat gatcatcgtg gcgcatgtat tactcatcct tttgggggcc actgagatac    600

tgcaagctga cttacttcct gatgaaaaga tttcacttct cccacctgtc aatttcacca    660

ttaaagttac tggtttggct caagttcttt tacaatggaa accaaatcct gatcaagagc    720

aaaggaatgt taatctagaa tatcaagtga aaataaacgc tccaaaagaa gatgactatg    780

aaaccagaat cactgaaagc aaatgtgtaa ccatcctcca caaaggcttt tcagcaagtg    840

tgcggaccat cctgcagaac gaccactcac tactggccag cagctgggct tctgctgaac    900

ttcatgcccc accagggtct cctggaacct caattgtgaa tttaacttgc accacaaaca    960

ctacagaaga caattattca cgtttaaggt cataccaagt ttcccttcac tgcacctggc   1020

ttgttggcac agatgcccct gaggacacgc agtattttct ctactatagg tatggctctt   1080

ggactgaaga atgccaagaa tacagcaaag acacactggg gagaaatatc gcatgctggt   1140

ttcccaggac ttttatcctc agcaaagggc gtgactggct tgcggtgctt gttaacggct   1200

ccagcaagca ctctgctatc aggccctttg atcagctgtt tgcccttcac gccattgatc   1260

aaataaatcc tccactgaat gtcacagcag agattgaagg aactcgtctc tctatccaat   1320

gggagaaacc agtgtctgct tttccaatcc attgctttga ttatgaagta aaaatacaca   1380

atacaaggaa tggatatttg cagatagaaa aattgatgac caatgcattc atctcaataa   1440

ttgatgatct ttctaagtac gatgttcaag tgagagcagc agtgagctcc atgtgcagag   1500

aggcagggct ctggagtgag tggagccaac ctatttatgt gggaaatgat gaacacaagc   1560

ccttgagaga gtggtttgtc attgtgatta tggcaaccat ctgcttcatc ttgttaattc   1620

tctcgcttat ctgtaaaata tgtcatttat ggatcaagtt gtttccacca attccagcac   1680

caaaaagtaa tatcaaagat ctctttgtaa ccactaacta tgagaaagct gggtccagtg   1740

agacggaaat tgaagtcatc tgttatatag agaagcctgg agttgagacc ctggaggatt   1800

ctgtgttttg actgtcactt tggcatcctc tgatgaactc acacatgcct cagtgcctca   1860

gtgaaaagaa cagggatgct ggctcttggc taagaggtgt tcagaattta ggcaacactc   1920

aatttacctg cgaagcaata cacccagaca caccagtctt gtatctctta aaagtatgga   1980

tgcttcatcc aaatcgcctc acctacagca gggaagttga ctcatccaag cattttgcca   2040

tgttttttct ccccatgccg tacagggtag cacctcctca cctgccaatc tttgcaattt   2100

gcttgactca cctcagactt ttcattcaca acagacagct tttaaggcta acgtccagct   2160

gtatttactt ctggctgtgc ccgtttggct gtttaagctg ccaattgtag cactcagcta   2220

ccatctgagg aagaaagcat tttgcatcag cctggagtga accatgaact tggattcaag   2280

actgtctttt ctatagcaa                                                2299


<210>  728
<211>  420
<212>  PRT
<213>  Homosapiens

<400>  728

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  729
<211>  1956
<212>  DNA
<213>  Homosapiens

<400>  729
agtacccacg gaaaacttgt ttaccttgtc accatgagta aaagttaatt cccactcctg     60

aagagagcaa accaactctg aaagagagtg aaaatgcaga caagacagtt atcagataat    120

ggctatctgg acgagagatt ctttcgtttg acagcagttt ggttgttggg agttccagtt    180

cagctcctgc acagttgctc tgtacaaatc ctcctccata tttgcttaga gaaaacgtgt    240

tgccatccca tcatgaagga agctgcctga gagtttttaa ccattacagc cgtgatgatg    300

aaagagtgaa gaaccgcctc taagttaaaa agtgcaccca gagataaggt tcgttctcaa    360

tgccctgccg ctgcttctca tcgcatggcc accgcatttc tcaggccagg cacattgagc    420

attggtcctg tgcctgacgc tatgctagat gctggggttg cagccacgag catagacacg    480

acagacacgg tcctcgccat cttctgttga gtactggtcg gaacaagagg atcgtctgta    540

gacaggatat gatcatcgtg gcgcatgtat tactcatcct tttgggggcc actgagatac    600

tgcaagctga cttacttcct gatgaaaaga tttcacttct cccacctgtc aatttcacca    660

ttaaagttac tggtttggct caagttcttt tacaatggaa accaaatcct gatcaagagc    720

aaaggaatgt taatctagaa tatcaagtga aaataaacgc tccaaaagaa gatgactatg    780

aaaccagaat cactgaaagc aaatgtgtaa ccatcctcca caaaggcttt tcagcaagtg    840

tgcggaccat cctgcagaac gaccactcac tactggccag cagctgggct tctgctgaac    900

ttcatgcccc accagggtct cctggaacct caattgtgaa tttaacttgc accacaaaca    960

ctacagaaga caattattca cgtttaaggt cataccaagt ttcccttcac tgcacctggc   1020

ttgttggcac agatgcccct gaggacacgc agtattttct ctactatagg tatggctctt   1080

ggactgaaga atgccaagaa tacagcaaag acacactggg gagaaatatc gcatgctggt   1140

ttcccaggac ttttatcctc agcaaagggc gtgactggct tgcggtgctt gttaacggct   1200

ccagcaagca ctctgctatc aggccctttg atcagctgtt tgcccttcac gccattgatc   1260

aaataaatcc tccactgaat gtcacagcag agattgaagg aactcgtctc tctatccaat   1320

gggagaaacc agtgtctgct tttccaatcc attgctttga ttatgaagta aaaatacaca   1380

atacaaggaa tggatatttg cagatagaaa aattgatgac caatgcattc atctcaataa   1440

ttgatgatct ttctaagtac gatgttcaag tgagagcagc agtgagctcc atgtgcagag   1500

aggcagggct ctggagtgag tggagccaac ctatttatgt gggtaagtag cttatgttta   1560

ttttacattg gcagccttcc ttgtgatcaa aaaaggtaat cccagaaacg tacccgttca   1620

ctcgtgggtc ttaaaatggt ttcatatctc tattgtgact aattttctct cggtctactg   1680

ccttttcaat caggaataga tttgccatga agccagtgaa gtttttaagt gtctaggctt   1740

ctcattagcg ccaactctcc tagacctggt gcctgttttt tttccaagtt ttgtttctac   1800

ttctatccat tttttaaatt aaacttttta ttttgaaata attatcacac tcacaagctg   1860

tgggaagaaa taatagagat cctgtgtctc tttcatccag ttttcctcaa gggtaacatc   1920

ttacaaaact atagtacaat agtggaatag aatatt                             1956


<210>  730
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  730

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Lys 
                325                 330             


<210>  731
<211>  1626
<212>  DNA
<213>  Homosapiens

<400>  731
agtacccacg gaaaacttgt ttaccttgtc accatgagta aaagttaatt cccactcctg     60

aagagagcaa accaactctg aaagagagtg aaaatgcaga caagacagtt atcagataat    120

ggctatctgg acgagagatt ctttcgtttg acagcagttt ggttgttggg agttccagtt    180

cagctcctgc acagttgctc tgtacaaatc ctcctccata tttgcttaga gaaaacgtgt    240

tgccatccca tcatgaagga agctgcctga gagtttttaa ccattacagc cgtgatgatg    300

aaagagtgaa gaaccgcctc taagttaaaa agtgcaccca gagataaggt tcgttctcaa    360

tgccctgccg ctgcttctca tcgcatggcc accgcatttc tcaggccagg cacattgagc    420

attggtcctg tgcctgacgc tatgctagat gctggggttg cagccacgag catagacacg    480

acagacacgg tcctcgccat cttctgttga gtactggtcg gaacaagagg atcgtctgta    540

gacaggatat gatcatcgtg gcgcatgtat tactcatcct tttgggggcc actgagatac    600

tgcaagctga cttacttcct gatgaaaaga tttcacttct cccacctgtc aatttcacca    660

ttaaagttac tggtttggct caagttcttt tacaatggaa accaaatcct gatcaagagc    720

aaaggaatgt taatctagaa tatcaagtga aaataaacgc tccaaaagaa gatgactatg    780

aaaccagaat cactgaaagc aaatgtgtaa ccatcctcca caaaggcttt tcagcaagtg    840

tgcggaccat cctgcagaac gaccactcac tactggccag cagctgggct tctgctgaac    900

ttcatgcccc accagggtct cctggaacct caattgtgaa tttaacttgc accacaaaca    960

ctacagaaga caattattca cgtttaaggt cataccaagt ttcccttcac tgcacctggc   1020

ttgttggcac agatgcccct gaggacacgc agtattttct ctactatagg tatggctctt   1080

ggactgaaga atgccaagaa tacagcaaag acacactggg gagaaatatc gcatgctggt   1140

ttcccaggac ttttatcctc agcaaagggc gtgactggct tgcggtgctt gttaacggct   1200

ccagcaagca ctctgctatc aggccctttg atcagctgtt tgcccttcac gccattgatc   1260

aaataaatcc tccactgaat gtcacagcag agattgaagg aactcgtctc tctatccaat   1320

gggagaaacc agtgtctgct tttccaatcc attgctttga ttatgaagta aaaatacaca   1380

atacaaggaa tggatatttg cagatagaaa aattgatgac caatgcattc atctcaataa   1440

ttgatgatct ttctaagtac gatgttcaag tgagagcagc agtgagctcc atgtgcagag   1500

aggcagggct ctggagtgag tggagccaac ctatttatgt ggggttctca agataaagga   1560

gataacatcc agctttcctg ccccacaccg tatctgaaat aaaaacaaca gcagggatag   1620

cagatt                                                              1626


<210>  732
<211>  335
<212>  PRT
<213>  Homosapiens

<400>  732

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Phe Ser Arg 
                325                 330                 335 


<210>  733
<211>  1865
<212>  DNA
<213>  Homosapiens

<400>  733
ggggggctgc ggcaacagcg gggccgatgt gtagttggtg actgcctctc cagatgctga     60

ggtgcctgta tcattggcac aggccagtgc tgaaccgtag gtggagtagg ctgtgccttc    120

tgaagcagta tctattcaca atgaagttgc agtctcccga attccagtca cttttcacag    180

aaggactgaa gagtctgaca gaattatttg tcaaagagaa tcacgaatta agaatagcag    240

gaggagcagt gagggattta ttaaatggag taaagcctca ggatatagat tttgccacca    300

ctgctacccc tactcaaatg aaggagatgt ttcagtcggc tgggattcgg atgataaaca    360

acagaggaga aaagcacgga acaattactg ccaggcttca tgaagaaaat tttgagatta    420

ctacactacg gattgatgtc accactgatg gaagacatgc tgaggtagaa tttacaactg    480

actggcagaa agatgcggaa cgcagagatc tcactataaa ttctatgttt ttaggttttg    540

atggcacttt atttgactac tttaatggtt atgaagattt aaaaaataag aaagttagat    600

ttgttggaca tgctaaacag agaatacaag aggattatct tagaatttta agatacttca    660

ggttttatgg gagaattgta gacaaacctg gtgaccatga tcctgagact ttggaagcaa    720

ttgcagaaaa tgcaaaaggc ttggctggaa tatcaggaga aaggatttgg gtggaactga    780

aaaaaattct tgttggtaac catgtaaatc atttgattca ccttatctat gatcttgatg    840

tggctcctta tataggttta cctgctaatg caagtttaga agaatttgac aaagtcagta    900

aaaatgttga tggtttttca ccaaagccag tgactctttt ggcctcatta ttcaaagtac    960

aagatgatgt cacaaaattg gatttgaggt tgaagatcgc gaaagaggag aaaaaccttg   1020

gcttatttat agttaaaaat aggaaagatt taattaaagc aacagatagt tcagacccat   1080

tgaaacccta tcaagacttc attatagatt ctagggaacc tgatgcaact actcgtgtat   1140

gtgaactact gaagtaccaa ggagagcact gtctcctaaa ggaaatgcag cagtggtcca   1200

ttcctccatt tcctgtaagt ggccatgaca tcagaaaagt gggcatttct tcaggaaaag   1260

aaattggggc tctattacaa cagttgcgag aacagtggaa aaaaagtggt taccaaatgg   1320

aaaaagatga acttctgagt tacataaaga agacctaaaa ctgatggcta ctaaaaagca   1380

gagcatttct gccagtcata acatctttgt actctatgag caaatagtaa ttttggacct   1440

tgataaaaca attttgtaga gtgtaatatt tctaagagga aatgtcacag gggctatgat   1500

gcaagaaagc ctcagaaatg actgcataca ggaaataatc tcatcatttc caaagatgtc   1560

ttcatgtccc atcaatgaca tgctaccaga catatcagat tccacaggat aatggcacca   1620

agctacccaa gtagatgttt ctggtattct agactgccgt tcatgcttgt ttcctaaagt   1680

atacttaaaa gtttcaaata cagtttcact tagaaactgc aaccctccaa gtaatgttat   1740

gtttacttag gtattaatgt tatgtttact taggtatgta tcagaggcaa taatttccaa   1800

agcagatctt agaatataac caatttgtta gataacaaaa aaaaaaaaaa aaaaaaaaaa   1860

aaaaa                                                               1865


<210>  734
<211>  405
<212>  PRT
<213>  Homosapiens

<400>  734

Met Lys Leu Gln Ser Pro Glu Phe Gln Ser Leu Phe Thr Glu Gly Leu 
1               5                   10                  15      


Lys Ser Leu Thr Glu Leu Phe Val Lys Glu Asn His Glu Leu Arg Ile 
            20                  25                  30          


Ala Gly Gly Ala Val Arg Asp Leu Leu Asn Gly Val Lys Pro Gln Asp 
        35                  40                  45              


Ile Asp Phe Ala Thr Thr Ala Thr Pro Thr Gln Met Lys Glu Met Phe 
    50                  55                  60                  


Gln Ser Ala Gly Ile Arg Met Ile Asn Asn Arg Gly Glu Lys His Gly 
65                  70                  75                  80  


Thr Ile Thr Ala Arg Leu His Glu Glu Asn Phe Glu Ile Thr Thr Leu 
                85                  90                  95      


Arg Ile Asp Val Thr Thr Asp Gly Arg His Ala Glu Val Glu Phe Thr 
            100                 105                 110         


Thr Asp Trp Gln Lys Asp Ala Glu Arg Arg Asp Leu Thr Ile Asn Ser 
        115                 120                 125             


Met Phe Leu Gly Phe Asp Gly Thr Leu Phe Asp Tyr Phe Asn Gly Tyr 
    130                 135                 140                 


Glu Asp Leu Lys Asn Lys Lys Val Arg Phe Val Gly His Ala Lys Gln 
145                 150                 155                 160 


Arg Ile Gln Glu Asp Tyr Leu Arg Ile Leu Arg Tyr Phe Arg Phe Tyr 
                165                 170                 175     


Gly Arg Ile Val Asp Lys Pro Gly Asp His Asp Pro Glu Thr Leu Glu 
            180                 185                 190         


Ala Ile Ala Glu Asn Ala Lys Gly Leu Ala Gly Ile Ser Gly Glu Arg 
        195                 200                 205             


Ile Trp Val Glu Leu Lys Lys Ile Leu Val Gly Asn His Val Asn His 
    210                 215                 220                 


Leu Ile His Leu Ile Tyr Asp Leu Asp Val Ala Pro Tyr Ile Gly Leu 
225                 230                 235                 240 


Pro Ala Asn Ala Ser Leu Glu Glu Phe Asp Lys Val Ser Lys Asn Val 
                245                 250                 255     


Asp Gly Phe Ser Pro Lys Pro Val Thr Leu Leu Ala Ser Leu Phe Lys 
            260                 265                 270         


Val Gln Asp Asp Val Thr Lys Leu Asp Leu Arg Leu Lys Ile Ala Lys 
        275                 280                 285             


Glu Glu Lys Asn Leu Gly Leu Phe Ile Val Lys Asn Arg Lys Asp Leu 
    290                 295                 300                 


Ile Lys Ala Thr Asp Ser Ser Asp Pro Leu Lys Pro Tyr Gln Asp Phe 
305                 310                 315                 320 


Ile Ile Asp Ser Arg Glu Pro Asp Ala Thr Thr Arg Val Cys Glu Leu 
                325                 330                 335     


Leu Lys Tyr Gln Gly Glu His Cys Leu Leu Lys Glu Met Gln Gln Trp 
            340                 345                 350         


Ser Ile Pro Pro Phe Pro Val Ser Gly His Asp Ile Arg Lys Val Gly 
        355                 360                 365             


Ile Ser Ser Gly Lys Glu Ile Gly Ala Leu Leu Gln Gln Leu Arg Glu 
    370                 375                 380                 


Gln Trp Lys Lys Ser Gly Tyr Gln Met Glu Lys Asp Glu Leu Leu Ser 
385                 390                 395                 400 


Tyr Ile Lys Lys Thr 
                405 


<210>  735
<211>  2264
<212>  DNA
<213>  Homosapiens

<400>  735
cgcgtggcgg cggtggcggc tgcggcaaca gcggggccga tgtgtagttg gtgactgcct     60

ctccagatgc tgaggtgcct gtatcattgg cacaggccag tgctgaaccg taggtggagt    120

aggctgtgcc ttctgaagca gtatctattc acaatgaagt tgcagtctcc cgaattccag    180

tcacttttca cagaaggact gaagagtctg acagaattat ttgtcaaaga gaatcacgaa    240

ttaagaatag caggaggagc agtgagggat ttattaaatg gagtaaagcc tcaggatata    300

gattttgcca ccactgctac ccctactcaa atgaaggaga tgtttcagtc ggctgggatt    360

cggatgataa acaacagagg agaaaagcac ggaacaatta ctgccaggct tcatgaagaa    420

aattttgaga ttactacact acggattgat gtcaccactg atggaagaca tgctgaggta    480

gaatttacaa ctgactggca gaaagatgcg gaacgcagag atctcactat aaattctatg    540

tttttaggtt ttgatggcac tttatttgac tactttaatg gttatgaaga tttaaaaaat    600

aagaaagtta gatttgttgg acatgctaaa cagagaatac aagaggatta tcttagaatt    660

ttaagatact tcaggtttta tgggagaatt gtagacaaac ctggtgacca tgatcctgag    720

actttggaag caattgcaga aaatgcaaaa ggcttggctg gaatatcagg agaaaggatt    780

tgggtggaac tgaaaaaaat tcttgttggt ttacctgcta atgcaagttt agaagaattt    840

gacaaagtca gtaaaaatgt tgatggtttt tcaccaaagc cagtgactct tttggcctca    900

ttattcaaag tacaagatga tgtcacaaaa ttggatttga ggttgaagat cgcgaaagag    960

gagaaaaacc ttggcttatt tatagttaaa aataggaaag atttaattaa agcaacagat   1020

agttcagacc cattgaaacc ctatcaagac ttcattatag attctaggga acctgatgca   1080

actactcgtg tatgtgaact actgaagtac caaggagagc actgtctcct aaaggaaatg   1140

cagcagtggt ccattcctcc atttcctgta agtggccatg acatcagaaa agtgggcatt   1200

tcttcaggaa aagaaattgg ggctctatta caacagttgc gagaacagtg gaaaaaaagt   1260

ggttaccaaa tggaaaaaga tgaacttctg agttacataa agaagaccta aaactgatgg   1320

ctactaaaaa gcagagcatt tctggtaaga ctaaattttc tcccctccct cttaatgagg   1380

ttttagagac tacaccagaa taaaagacag tttaggggac ctctgtagaa caacaagggt   1440

cttattttgt gaattatata tttcaagaac taaacagaga tccacctttc tggatctgat   1500

ttatatcact gaaatgtaca gttcttttgg aatagtttca cctgagaaaa catagttggc   1560

tattatctat cttaacctgt tcaggctttt aaaaaaaact gtttttgcat agggtagtac   1620

taagatctta aaaagtggta actgtcttga agaaaaaacg tttattgttt gtttgcaatt   1680

gaaataacag ggttacctta acaatgactg tctatgatgt gtcagttctt atctgaattc   1740

caaaataaac ctgtgcttaa aaaagaaata attgaccaag taagtttgca taaaatgtga   1800

atactaaatg tgtccccagt tgctggcatt catatgtaca ggatttgttc tagcaagcta   1860

tgcttcagta tgtggttgat atttttctgt cacaatgatt tctttatgca tgcagagcct   1920

gggaaagtca tgggattaac ttgagggtca ctattgagcc tattaattaa ttaattattg   1980

ttttaataaa acaaacattg gtattggaag ataaatatgt ttatgtggta tctgacaatg   2040

tgtattaggt gtcatataca atggtaatat gcctgtcttt aaagtgttat tttattaatt   2100

aaaaggatat ggctattatt atatattctc taaagattta ttctctaaag atttgagtcc   2160

taaatgcttt catcaggtaa ataaaatgta taatacaaaa aaaaaaaaaa aaaaaaaaaa   2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                    2264


<210>  736
<211>  414
<212>  PRT
<213>  Homosapiens

<400>  736

Met Leu Arg Cys Leu Tyr His Trp His Arg Pro Val Leu Asn Arg Arg 
1               5                   10                  15      


Trp Ser Arg Leu Cys Leu Leu Lys Gln Tyr Leu Phe Thr Met Lys Leu 
            20                  25                  30          


Gln Ser Pro Glu Phe Gln Ser Leu Phe Thr Glu Gly Leu Lys Ser Leu 
        35                  40                  45              


Thr Glu Leu Phe Val Lys Glu Asn His Glu Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Val Arg Asp Leu Leu Asn Gly Val Lys Pro Gln Asp Ile Asp Phe 
65                  70                  75                  80  


Ala Thr Thr Ala Thr Pro Thr Gln Met Lys Glu Met Phe Gln Ser Ala 
                85                  90                  95      


Gly Ile Arg Met Ile Asn Asn Arg Gly Glu Lys His Gly Thr Ile Thr 
            100                 105                 110         


Ala Arg Leu His Glu Glu Asn Phe Glu Ile Thr Thr Leu Arg Ile Asp 
        115                 120                 125             


Val Thr Thr Asp Gly Arg His Ala Glu Val Glu Phe Thr Thr Asp Trp 
    130                 135                 140                 


Gln Lys Asp Ala Glu Arg Arg Asp Leu Thr Ile Asn Ser Met Phe Leu 
145                 150                 155                 160 


Gly Phe Asp Gly Thr Leu Phe Asp Tyr Phe Asn Gly Tyr Glu Asp Leu 
                165                 170                 175     


Lys Asn Lys Lys Val Arg Phe Val Gly His Ala Lys Gln Arg Ile Gln 
            180                 185                 190         


Glu Asp Tyr Leu Arg Ile Leu Arg Tyr Phe Arg Phe Tyr Gly Arg Ile 
        195                 200                 205             


Val Asp Lys Pro Gly Asp His Asp Pro Glu Thr Leu Glu Ala Ile Ala 
    210                 215                 220                 


Glu Asn Ala Lys Gly Leu Ala Gly Ile Ser Gly Glu Arg Ile Trp Val 
225                 230                 235                 240 


Glu Leu Lys Lys Ile Leu Val Gly Leu Pro Ala Asn Ala Ser Leu Glu 
                245                 250                 255     


Glu Phe Asp Lys Val Ser Lys Asn Val Asp Gly Phe Ser Pro Lys Pro 
            260                 265                 270         


Val Thr Leu Leu Ala Ser Leu Phe Lys Val Gln Asp Asp Val Thr Lys 
        275                 280                 285             


Leu Asp Leu Arg Leu Lys Ile Ala Lys Glu Glu Lys Asn Leu Gly Leu 
    290                 295                 300                 


Phe Ile Val Lys Asn Arg Lys Asp Leu Ile Lys Ala Thr Asp Ser Ser 
305                 310                 315                 320 


Asp Pro Leu Lys Pro Tyr Gln Asp Phe Ile Ile Asp Ser Arg Glu Pro 
                325                 330                 335     


Asp Ala Thr Thr Arg Val Cys Glu Leu Leu Lys Tyr Gln Gly Glu His 
            340                 345                 350         


Cys Leu Leu Lys Glu Met Gln Gln Trp Ser Ile Pro Pro Phe Pro Val 
        355                 360                 365             


Ser Gly His Asp Ile Arg Lys Val Gly Ile Ser Ser Gly Lys Glu Ile 
    370                 375                 380                 


Gly Ala Leu Leu Gln Gln Leu Arg Glu Gln Trp Lys Lys Ser Gly Tyr 
385                 390                 395                 400 


Gln Met Glu Lys Asp Glu Leu Leu Ser Tyr Ile Lys Lys Thr 
                405                 410                 


<210>  737
<211>  2231
<212>  DNA
<213>  Homosapiens

<400>  737
cctttgcggg taaacagaca tggccggcga aggagatcag caggacgctg cgcacaacat     60

gggcaaccac ctgccgctcc tgcctgcaga gagtgaggaa gaagatgaaa tggaagttga    120

agaccaggat agtaaagaag ccaaaaaacc aaacatcata aattttgaca ccagtctgcc    180

gacatcacat acatacctag gtgctgatat ggaagaattt catggcagga ctttgcacga    240

tgacgacagc tgtcaggtga ttccagttct tccacaagtg atgatgatcc tgattcccgg    300

acagacatta cctcttcagc tttttcaccc tcaagaagtc agtatggtgc ggaatttaat    360

tcagaaagat agaacctttg ctgttcttgc atacagcaat gtacaggaaa gggaagcaca    420

gtttggaaca acagcagaga tatatgccta tcgagaagaa caggattttg gaattgagat    480

agtgaaagtg aaagcaattg gaagacaaag gttcaaagtc cttgagctaa gaacacagtc    540

agatggaatc cagcaagcta aagtgcaaat tcttcccgaa tgtgtgttgc cttcaaccat    600

gtctgcagtt caattagaat ccctcaataa gtgccagata tttccttcaa aacctgtctc    660

aagagaagac caatgttcat ataaatggtg gcagaaatac cagaagagaa agtttcattg    720

tgcaaatcta acttcatggc ctcgctggct gtattcctta tatgatgctg agaccttaat    780

ggacagaatc aagaaacagc tacgtgaatg ggatgaaaat ctaaaagatg attctcttcc    840

ttcaaatcca atagattttt cttacagagt agctgcttgt cttcctattg atgatgtatt    900

gagaattcag ctccttaaaa ttggcagtgc tatccagcga cttcgctgtg aattagacat    960

tatgaataaa tgtacttccc tttgctgtaa acaatgtcaa gaaacagaaa taacaaccaa   1020

aaatgaaata ttcagtttat ccttatgtgg gccgatggca gcttatgtga atcctcatgg   1080

atatgtgcat gagacactta ctgtgtataa ggcttgcaac ttgaatctga taggccggcc   1140

ttctacagaa cacagctggt ttcctgggta tgcctggact gttgcccagt gtaagatctg   1200

tgcaagccat attggatgga agtttacggc caccaaaaaa gacatgtcac ctcaaaaatt   1260

ttggggctta acgcgatctg ctctgttgcc cacgatccca gacactgaag atgaaataag   1320

tccagacaaa gtaatacttt gcttgtaaac agatgtgata gagataaagt tatctaacaa   1380

attggttata ttctaagatc tgctttggaa attattgcct ctgatacata cctaagtaaa   1440

cataacatta atacctaagt aaacataaca ttacttggag ggttgcagtt tctaagtgaa   1500

actgtatttg aaacttttaa gtatacttta ggaaacaagc atgaacggca gtctagaata   1560

ccagaaacat ctacttgggt agcttggtgc cattatcctg tggaatctga tatgtctggt   1620

agcatgtcat tgatgggaca tgaagacatc tttggaaatg atgagattat ttcctgtgtt   1680

aaaaaaaaaa aaaatcttaa attcctacaa tgtgaaactg aaactaataa tttgatcctg   1740

atgtatggga cagcgtatct gtaccagtgc tctaaataac aaaagctagg gtgacaagta   1800

catgttcctt ttggaaagaa gcaaggcaat gtatattaat tattctaaaa gggctttgtt   1860

cctttccatt ttctttaact tctctgagat actgatttgt aaattttgaa aattagttaa   1920

aatatgcagt tttttgagcc cacgaatagt tgtcatttcc tttatgtgcc tgttagtaaa   1980

aagtagtatt gtgtatttgc tcagtatctg aactataagc ccatttatac tgttccatac   2040

aaaagctatt tttcaaaaat taatttgaac caaaactact actataggga aaagatgcca   2100

aaacatgtcc cctcacccag gctaaacttg atactgtatt attttgttca atgtaaattg   2160

aagaaaatct gtaagtaagt aaaccttaag tgtgaaacta aaaaaaaaaa aaaaaaaaaa   2220

aaaaaaaaaa a                                                        2231


<210>  738
<211>  442
<212>  PRT
<213>  Homosapiens

<400>  738

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu 
        275                 280                 285             


Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala 
    290                 295                 300                 


Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser 
305                 310                 315                 320 


Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu 
                325                 330                 335     


Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro 
            340                 345                 350         


His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu 
        355                 360                 365             


Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr 
    370                 375                 380                 


Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp 
385                 390                 395                 400 


Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly 
                405                 410                 415     


Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu 
            420                 425                 430         


Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440         


<210>  739
<211>  2063
<212>  DNA
<213>  Homosapiens

<400>  739
caaagacgac acggccttgt gggatggcgg agtttaagga gaagcctgag gccccgactg     60

agcagctgga tgtcgcgtgc ggccaggaaa acttgccggt gggcgcgtgg cccccggggg    120

ccgcgccggc gcccttccag tacactcctg atcatgtagt tggacctgga gcagacattg    180

atcccactca aataaccttt cccggatgca tttgtgtcaa aactccctgc ctccctggca    240

cttgctcctg tctccgccat ggagagaact atgatgataa ctcatgcctt agagatatag    300

gatctggagg aaagtatgca gagcctgttt ttgaatgcaa tgtcctgtgc cgatgcagtg    360

accactgcag aaacagagtg gtccagaaag gtctacagtt ccacttccaa gtgttcaaga    420

cgcataaaaa aggctgggga cttcgtacct tggaatttat accgaaagga aggtttgtct    480

gtgaatatgc tggtgaggtt ttaggattct ctgaagttca gagaagaatt cacttacaaa    540

caaaatccga ctccaattac attatagcca tcagggaaca tgtttataat gggcaggtaa    600

tggaaacatt tgttgaccct acttatatag gaaatattgg aagattcctt aatcattctt    660

gtgagccaaa ccttttgatg attcctgtcc gaattgactc aatggtacct aagttggcac    720

tttttgcagc caaagatatt gtgccagaag aagaactctc ttatgattat tcaggaagat    780

atcttaatct aacagtcagt gcctccaaag aaaggctaga tcatgggaaa ctaaggaaac    840

cttgttactg tggtgccaaa tcatgtactg ctttcctgcc ttttgacagt tctctgtact    900

gccccgtaga aaagtcgaac atcagttgtg gaaatgagaa ggaacccagc atgtgtggct    960

cagccccttc tgtgttcccc tcctgcaagc gattgaccct tgagactatg aaaatgatgt   1020

tagacaaaaa gcaaattcga gcaattttct tattcgagtt caaaatgggt cgtaaagcag   1080

cagaaacaac tcgcaacatc aacaatgcat ttggcccagg aactgctaac gaacgtacag   1140

tgcagtggtg gttcaagaag ttttgcaaag gagatgagag ccttgaagat gaggagcgta   1200

gtggccggcc atcagaagtt gacaacgacc agttgagagc aatcatcgaa gctgatcccc   1260

ttacaactac acgagaagtt gctgaagaac tcaatgtcaa ccattctacg gtcgttcggc   1320

atttgaagca aattgaaaag gtgaaaaagc tcgataagtg ggtgcctcat gagctgactg   1380

aaaatcaaaa aaatcgtcgt tttgaagtgt catcttctct tattctacgc aaccacaacg   1440

aaccatttct cgatcggatt gtgacgtgtg atgaaaagtg gattttatat gacaaccggc   1500

gacgatcagc tcagtggttg gatcaagaag aagctccaaa gcacttccca aagccaatct   1560

tgcacccaaa aaaggtcatg gtcactattt ggtggtctgc tgctggtctg atccactaca   1620

gctttctgaa tcccggtgaa accattacat ctgagaagta tgctcaggaa atcgatgaga   1680

tgaaccaaaa actgcaacgc ctgcagctgg cattggtcaa cagaaagggc ccaattcttc   1740

tccacgacaa tgcccgaccg catgttgcac aacccacact tcaaaagttg aatgaattgg   1800

gctatgaagt tttgcctcat ccaccgtatt cacctgacct cttgccaacc aactaccacg   1860

tctttaagca tctcaacaac tttttgcagg gaaaacgctt ccacaaccag caggatgcag   1920

aaaatgcttt ccaagagttc gtcgaatccc aaagcacgga tttttacgct acaggaataa   1980

accaacttat ttctcgttgg caaaaatgtg ttgattgtaa tggttcctat tttgattaat   2040

aaaaatgcgt tgagcctaaa aaa                                           2063


<210>  740
<211>  671
<212>  PRT
<213>  Homosapiens

<400>  740

Met Ala Glu Phe Lys Glu Lys Pro Glu Ala Pro Thr Glu Gln Leu Asp 
1               5                   10                  15      


Val Ala Cys Gly Gln Glu Asn Leu Pro Val Gly Ala Trp Pro Pro Gly 
            20                  25                  30          


Ala Ala Pro Ala Pro Phe Gln Tyr Thr Pro Asp His Val Val Gly Pro 
        35                  40                  45              


Gly Ala Asp Ile Asp Pro Thr Gln Ile Thr Phe Pro Gly Cys Ile Cys 
    50                  55                  60                  


Val Lys Thr Pro Cys Leu Pro Gly Thr Cys Ser Cys Leu Arg His Gly 
65                  70                  75                  80  


Glu Asn Tyr Asp Asp Asn Ser Cys Leu Arg Asp Ile Gly Ser Gly Gly 
                85                  90                  95      


Lys Tyr Ala Glu Pro Val Phe Glu Cys Asn Val Leu Cys Arg Cys Ser 
            100                 105                 110         


Asp His Cys Arg Asn Arg Val Val Gln Lys Gly Leu Gln Phe His Phe 
        115                 120                 125             


Gln Val Phe Lys Thr His Lys Lys Gly Trp Gly Leu Arg Thr Leu Glu 
    130                 135                 140                 


Phe Ile Pro Lys Gly Arg Phe Val Cys Glu Tyr Ala Gly Glu Val Leu 
145                 150                 155                 160 


Gly Phe Ser Glu Val Gln Arg Arg Ile His Leu Gln Thr Lys Ser Asp 
                165                 170                 175     


Ser Asn Tyr Ile Ile Ala Ile Arg Glu His Val Tyr Asn Gly Gln Val 
            180                 185                 190         


Met Glu Thr Phe Val Asp Pro Thr Tyr Ile Gly Asn Ile Gly Arg Phe 
        195                 200                 205             


Leu Asn His Ser Cys Glu Pro Asn Leu Leu Met Ile Pro Val Arg Ile 
    210                 215                 220                 


Asp Ser Met Val Pro Lys Leu Ala Leu Phe Ala Ala Lys Asp Ile Val 
225                 230                 235                 240 


Pro Glu Glu Glu Leu Ser Tyr Asp Tyr Ser Gly Arg Tyr Leu Asn Leu 
                245                 250                 255     


Thr Val Ser Ala Ser Lys Glu Arg Leu Asp His Gly Lys Leu Arg Lys 
            260                 265                 270         


Pro Cys Tyr Cys Gly Ala Lys Ser Cys Thr Ala Phe Leu Pro Phe Asp 
        275                 280                 285             


Ser Ser Leu Tyr Cys Pro Val Glu Lys Ser Asn Ile Ser Cys Gly Asn 
    290                 295                 300                 


Glu Lys Glu Pro Ser Met Cys Gly Ser Ala Pro Ser Val Phe Pro Ser 
305                 310                 315                 320 


Cys Lys Arg Leu Thr Leu Glu Thr Met Lys Met Met Leu Asp Lys Lys 
                325                 330                 335     


Gln Ile Arg Ala Ile Phe Leu Phe Glu Phe Lys Met Gly Arg Lys Ala 
            340                 345                 350         


Ala Glu Thr Thr Arg Asn Ile Asn Asn Ala Phe Gly Pro Gly Thr Ala 
        355                 360                 365             


Asn Glu Arg Thr Val Gln Trp Trp Phe Lys Lys Phe Cys Lys Gly Asp 
    370                 375                 380                 


Glu Ser Leu Glu Asp Glu Glu Arg Ser Gly Arg Pro Ser Glu Val Asp 
385                 390                 395                 400 


Asn Asp Gln Leu Arg Ala Ile Ile Glu Ala Asp Pro Leu Thr Thr Thr 
                405                 410                 415     


Arg Glu Val Ala Glu Glu Leu Asn Val Asn His Ser Thr Val Val Arg 
            420                 425                 430         


His Leu Lys Gln Ile Glu Lys Val Lys Lys Leu Asp Lys Trp Val Pro 
        435                 440                 445             


His Glu Leu Thr Glu Asn Gln Lys Asn Arg Arg Phe Glu Val Ser Ser 
    450                 455                 460                 


Ser Leu Ile Leu Arg Asn His Asn Glu Pro Phe Leu Asp Arg Ile Val 
465                 470                 475                 480 


Thr Cys Asp Glu Lys Trp Ile Leu Tyr Asp Asn Arg Arg Arg Ser Ala 
                485                 490                 495     


Gln Trp Leu Asp Gln Glu Glu Ala Pro Lys His Phe Pro Lys Pro Ile 
            500                 505                 510         


Leu His Pro Lys Lys Val Met Val Thr Ile Trp Trp Ser Ala Ala Gly 
        515                 520                 525             


Leu Ile His Tyr Ser Phe Leu Asn Pro Gly Glu Thr Ile Thr Ser Glu 
    530                 535                 540                 


Lys Tyr Ala Gln Glu Ile Asp Glu Met Asn Gln Lys Leu Gln Arg Leu 
545                 550                 555                 560 


Gln Leu Ala Leu Val Asn Arg Lys Gly Pro Ile Leu Leu His Asp Asn 
                565                 570                 575     


Ala Arg Pro His Val Ala Gln Pro Thr Leu Gln Lys Leu Asn Glu Leu 
            580                 585                 590         


Gly Tyr Glu Val Leu Pro His Pro Pro Tyr Ser Pro Asp Leu Leu Pro 
        595                 600                 605             


Thr Asn Tyr His Val Phe Lys His Leu Asn Asn Phe Leu Gln Gly Lys 
    610                 615                 620                 


Arg Phe His Asn Gln Gln Asp Ala Glu Asn Ala Phe Gln Glu Phe Val 
625                 630                 635                 640 


Glu Ser Gln Ser Thr Asp Phe Tyr Ala Thr Gly Ile Asn Gln Leu Ile 
                645                 650                 655     


Ser Arg Trp Gln Lys Cys Val Asp Cys Asn Gly Ser Tyr Phe Asp 
            660                 665                 670     


<210>  741
<211>  2148
<212>  DNA
<213>  Homosapiens

<400>  741
cgggtcacat ggcccgcggg acaacatggc tgcgcccgca ctagggctgg tgtgtggacg     60

ttgccctgag ctgggtctcg tcctcttgct gctgctgctc tcgctgctgt gtggagcggc    120

agggagccag gaggccggga ccggtgcggg cgcggggtcc cttgcgggtt cttgcggctg    180

cggcacgccc cagcggcctg gcgcccatgg cagttcggca gccgctcacc gatactcgcg    240

ggaggctaac gctccgggcc ccgtacccgg agagcggcaa ctcgcgcact caaagatggt    300

ccccatccct gctggagtat ttacaatggg cacagatgat cctcagataa agcaggatgg    360

ggaagcacct gcgaggagag ttactattga tgccttttac atggatgcct atgaagtcag    420

taatactgaa tttgagaagt ttgtgaactc aactggctat ttgacagagg ctgagaagtt    480

tggcgactcc tttgtctttg aaggcatgtt gagtgagcaa gtgaagacca atattcaaca    540

ggcagttgca gctgctccct ggtggttacc tgtgaaaggc gctaactgga gacacccaga    600

agggcctgac tctactattc tgcacaggcc ggatcatcca gttctccatg tgtcctggaa    660

tgatgcggtt gcctactgca cttgggcagg gaagcggctg cccacggaag ctgagtggga    720

atacagctgt cgaggaggcc tgcataatag acttttcccc tggggcaaca aactgcagcc    780

caaaggccag cattatgcca acatttggca gggcgagttt ccggtgacca acactggtga    840

ggatggcttc caaggaactg cgcctgttga tgccttccct cccaatggtt atggcttata    900

caacatagtg gggaacgcat gggaatggac ttcagactgg tggactgttc atcattctgt    960

tgaagaaacg cttaacccaa aaggtccccc ttctgggaaa gaccgagtga agaaaggtgg   1020

atcctacatg tgccataggt cttattgtta caggtatcgc tgtgctgctc ggagccagaa   1080

cacacctgat agctctgctt cgaatctggg attccgctgt gcagccgacc gcctgcccac   1140

tatggactga caaccaagga aagtcttccc cagtccaagg agcagtcgtg tctgacctac   1200

attgggcttt tctcagaact ttgaacgatc ccatgcaaag aattcccacc ctgaggtggg   1260

ttacatacct gcccaatggc caaaggaacc gccttgtgag accaaattgc tgacctgggt   1320

cagtgcatgt gctttatggt gtggtgcatc tttggagatc atcaccatat tttacttttg   1380

agagtcttta aagaggaagg ggagtggagg gaaccctgag ctaggcttca ggaggcccgc   1440

gtcctacgca ggctctgcca caggggttag accccaggtc cgacgcttga ccttcctggg   1500

cctcaagtgc cctcccctat caaatgaagg gatggacagc atgacctctg ggtgtctctc   1560

caactcacca gttctaaaaa gggtatcaga ttctattgtg acttcatagt gagaatttat   1620

tatagattat tttttagcta ttttttccat gtgtgaacct tgagtgatac taatcatgta   1680

aagtaagagt tctcttatgt attattttcg gaagaggggt gtggtgactc ctttatattc   1740

gtactgcact ttgtttttcc aaggaaatca gtgtctttta cgttgttatg atgaatccca   1800

catggggccg gtgatggtat gctgaagttc agccgttgaa cacataggaa tgtctgtggg   1860

gtgactctac tgtgctttat cttttaacat taagtgcctt tggttcagag gggcagtcat   1920

aagctctgtt tccccctctc cccaaagcct tcagcgaacg tgaaatgtgc gctaaacggg   1980

gaaacctgtt taattctaga tatagggaaa aaggaacgag gaccttgaat gagctatatt   2040

cagggtatcc ggtattttgt aatagggaat aggaaacctt gttggctgtg gaatatccga   2100

tgctttgaat catgcactgt gttgaataaa cgtatctgct aaatcagg                2148


<210>  742
<211>  374
<212>  PRT
<213>  Homosapiens

<400>  742

Met Ala Ala Pro Ala Leu Gly Leu Val Cys Gly Arg Cys Pro Glu Leu 
1               5                   10                  15      


Gly Leu Val Leu Leu Leu Leu Leu Leu Ser Leu Leu Cys Gly Ala Ala 
            20                  25                  30          


Gly Ser Gln Glu Ala Gly Thr Gly Ala Gly Ala Gly Ser Leu Ala Gly 
        35                  40                  45              


Ser Cys Gly Cys Gly Thr Pro Gln Arg Pro Gly Ala His Gly Ser Ser 
    50                  55                  60                  


Ala Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Ala Pro Gly Pro Val 
65                  70                  75                  80  


Pro Gly Glu Arg Gln Leu Ala His Ser Lys Met Val Pro Ile Pro Ala 
                85                  90                  95      


Gly Val Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys Gln Asp Gly 
            100                 105                 110         


Glu Ala Pro Ala Arg Arg Val Thr Ile Asp Ala Phe Tyr Met Asp Ala 
        115                 120                 125             


Tyr Glu Val Ser Asn Thr Glu Phe Glu Lys Phe Val Asn Ser Thr Gly 
    130                 135                 140                 


Tyr Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Glu Gly 
145                 150                 155                 160 


Met Leu Ser Glu Gln Val Lys Thr Asn Ile Gln Gln Ala Val Ala Ala 
                165                 170                 175     


Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro Glu 
            180                 185                 190         


Gly Pro Asp Ser Thr Ile Leu His Arg Pro Asp His Pro Val Leu His 
        195                 200                 205             


Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys Arg 
    210                 215                 220                 


Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu His 
225                 230                 235                 240 


Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys Gly Gln His 
                245                 250                 255     


Tyr Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Thr Asn Thr Gly Glu 
            260                 265                 270         


Asp Gly Phe Gln Gly Thr Ala Pro Val Asp Ala Phe Pro Pro Asn Gly 
        275                 280                 285             


Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser Asp 
    290                 295                 300                 


Trp Trp Thr Val His His Ser Val Glu Glu Thr Leu Asn Pro Lys Gly 
305                 310                 315                 320 


Pro Pro Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser Tyr Met Cys 
                325                 330                 335     


His Arg Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser Gln Asn 
            340                 345                 350         


Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala Ala Asp 
        355                 360                 365             


Arg Leu Pro Thr Met Asp 
    370                 


<210>  743
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  743
gttgctgtcg gagagagaaa gccgcacccg agaggaggtg tgggtgttcc gcttccatcc     60

taacggaacg agctccctct tcgcggacat gggattaccc agcggctgct aacccctctc    120

ctcgccctgc tcccccaaac cggcgtggct ccccgggcac caaggagctg actacagagg    180

agcaggattt gcacccctcg ctgggcttgc tttggcaaca gagtgcctga cccaggtcag    240

gattttcaag aaagacatgt ctgacaaaat gtctagcttc ctacatattg gagacatttg    300

ttctctgtac gcggagggat cgacaaatgg atttattagc accttgggcc tggttgatga    360

tcgttgtgtt gtacagccag aaaccgggga ccttaacaat ccacctaaga aattcagaga    420

ctgcctcttt aagctatgtc ccatgaaccg ctactctgcc caaaagcagt tctggaaagc    480

cgctaagcct ggggccaaca gcaccacaga cgcagtgcta ctcaacaaac tgcaccacgc    540

tgcagacttg gaaaagaagc agaatgagac agaaaacagg aaattgctgg ggaccgtaat    600

ccagtatggc aatgtgatcc agctcctgca tttgaaaagt aataaatacc taacagtgaa    660

taagaggctt cctgctctgt tggagaagaa tgccatgaga gtcacattgg acgaggctgg    720

aaatgaaggg tcctggtttt atattcagcc attctacaag ctgcgatcca ttggagacag    780

cgtggtcata ggtgacaagg tggttctgaa ccccgtcaat gctggtcagc ccctacatgc    840

tagcagccat caactggtag ataacccagg ctgcaatgag gtcaattccg tcaactgcaa    900

tacaagctgg aaaatagtcc ttttcatgaa atggagtgat aacaaagacg acatattaaa    960

ggggggtgac gtggtgaggc tgtttcatgc tgagcaggag aagtttctca cctgtgacga   1020

acacaggaag aagcagcacg tcttcctgag aaccacgggc cggcagtcgg ccacatctgc   1080

caccagttca aaagccctgt gggaggtgga ggtggtccag catgacccat gtcggggcgg   1140

agcagggtat tggaacagcc ttttccgttt caagcatctg gccacggggc attacttggc   1200

agcagaggtg gaccctgatc aggacgcctc tcgaagtagg ttgcggaatg cccaagaaaa   1260

gatggtatac tccctggtct ctgtgcctga aggcaatgac atctcctcca ttttcgagct   1320

agatcccacc actctgcgtg gaggtgacag ccttgtccca aggaactctt atgttcggct   1380

cagacaccta tgtactaata cctgggttca cagcacaaat attcctattg acaaggaaga   1440

agaaaagccc gtgatgctga aaattggcac ctctcctgtg aaggaggata aggaagcatt   1500

tgccatagtt ccggtttctc ctgctgaagt tcgggacctg gactttgcca atgatgccag   1560

caaggtgctg ggctccattg ctgggaagct agagaagggc accatcaccc agaatgaaag   1620

gaggtctgta accaagctgc tagaagattt ggtttacttc gtcactggtg gaactaattc   1680

tggtcaagat gttctcgaag ttgtcttctc caagcccaac agagaacggc agaaactgat   1740

gagagaacag aatattctca agcagatctt caagttgtta caagccccat tcacagactg   1800

cggtgatggc ccaatgcttc ggctggaaga gctcggggac cagcggcacg ctcctttcag   1860

acacatctgc cggctctgct acagggtgct gagacactcg cagcaagact acaggaagaa   1920

ccaggagtat atagccaagc agtttggctt catgcagaag cagattggct atgatgtgtt   1980

ggctgaagac actatcactg ccctgctcca caataatcgg aaactcctgg aaaaacacat   2040

taccgcggca gagattgaca catttgtcag cctggtgcga aagaacaggg agcccagatt   2100

cttagattac ctctccgacc tctgtgtctc catgaacaaa tcaattccag tgacccagga   2160

actgatatgt aaagctgtgc tgaaccccac caacgctgac atcctgattg agaccaaatt   2220

ggttctttct cgttttgaat ttgaaggtgt ctcttccact ggagagaatg ctctggaggc   2280

aggagaagac gaggaagagg tgtggctgtt ttggagggac agcaacaaag agattcgcag   2340

caagagtgtg agggaattgg ctcaggatgc taaagaaggg cagaaggagg accgagacgt   2400

tctcagctac tacagatatc agctgaacct ctttgcgagg atgtgtctgg accgccaata   2460

cctggccatc aacgaaatct caggccagct ggatgtcgat ctcattctcc gctgcatgtc   2520

tgacgagaac ctgccctatg acctcagggc gtccttctgc cgcctcatgc ttcacatgca   2580

tgtggaccga gatccccagg aacaagtcac ccccgtgaaa tatgcccgcc tctggtcgga   2640

gattccctcg gagatcgcca ttgacgacta tgatagtagt ggagcttcca aagatgaaat   2700

taaggagaga tttgctcaga ccatggagtt tgtggaggag tatttaagag atgtggtttg   2760

tcagaggttc cctttctctg ataaagagaa gaataagctt acgtttgagg ttgtaaattt   2820

agctaggaat ctcatatact ttggtttcta caacttctct gaccttctcc gattaactaa   2880

gatccttctg gccatattgg actgtgtaca tgtgacaaca atcttcccca ttagcaagat   2940

ggcgaaagga gaagagaata aaggcagtaa cgtgatgaga tctattcatg gcgtgggaga   3000

gctgatgacc caggtggtgc tccggggagg aggctttttg cccatgactc ccatggctgc   3060

tgcccctgaa ggcaatgtga agcaggcaga gcctgagaag gaggacatca tggtcatgga   3120

caccaagctg aagatcattg agatactcca gtttattttg aatgtgaggt tggattatag   3180

gatctcctgc ctcctgtgta tatttaagcg agagtttgat gaaagcaatt cccagacttc   3240

agaaacatcc tccggaaaca gcagccaaga agggccaagt aatgtaccag gtgctcttga   3300

ctttgaacac attgaagaac aagcagaagg catctttgga ggaagtgagg agaacacccc   3360

actggacttg gatgaccacg gcggcagaac ctttctccgt gtcctgctcc acttgacgat   3420

gcatgactac ccacccctgg tgtcaggggc cctgcagctc ctcttccggc acttcagcca   3480

gaggcaggag gtgctccagg ccttcaaaca ggttcaactg ctggttacca gccaagatgt   3540

ggacaactac aaacagatca aacaagactt ggatcaactg aggtccatcg tggaaaagtc   3600

agagctttgg gtgtacaaag ggcagggccc cgatgagact atggatggtg catctggaga   3660

aaatgaacat aagaaaacgg aggagggaaa taacaagcca caaaagcatg aaagcaccag   3720

cagctacaac tacagagtgg tcaaagagat tttgattcgg cttagcaaac tctgtgttca   3780

agagagtgcc tcagtgagaa agagcaggaa gcagcaacag cgtctgctcc ggaacatggg   3840

cgcgcacgcc gtggtgctgg agctgctgca gattccctat gagaaggccg aagataccaa   3900

gatgcaagag ataatgaggt tggctcatga atttttgcag aatttctgcg caggcaacca   3960

gcagaatcaa gctttgctac ataaacacat aaacctgttt ctcaacccag ggatcctgga   4020

ggcagtaacc atgcagcaca tcttcatgaa caatttccag ctttgcagtg agatcaacga   4080

gagagttgtt cagcacttcg ttcactgcat agagactcac ggtcggaatg tccagtatat   4140

aaagttctta cagacaattg tcaaggcaga agggaaattt attaaaaaat gccaagacat   4200

ggttatggcc gagctggtca attcgggaga ggatgtcctc gtgttctaca acgacagagc   4260

ctctttccag actctgatcc agatgatgcg gtcagaacgg gatcggatgg atgagaacag   4320

ccctctcatg taccacatcc acttggtcga gctcctggct gtgtgcacgg agggtaagaa   4380

tgtctacaca gagatcaagt gcaactccct gctcccgctg gatgacatcg ttcgcgtggt   4440

gacccacgag gactgcatcc ctgaggttaa aattgcatac attaacttcc tgaatcactg   4500

ctatgtggat acagaggtgg aaatgaagga gatttatacc agcaatcaca tgtggaaatt   4560

gtttgagaat ttccttgtag acatctgcag ggcctgtaac aacactagtg acaggaaaca   4620

tgcagactcg attttggaga agtatgtcac cgaaatcgtc atgagtattg ttactacttt   4680

cttcagctct cccttctcag accagagtac gactttgcag actcgccagc ctgtctttgt   4740

gcaactgctg caaggcgtgt tcagggttta ccactgcaac tggttaatgc caagccaaaa   4800

agcctccgtg gagagctgta ttcgggtgct gtctgatgta gccaagagcc gggccattgc   4860

cattcccgtg gacctggaca gccaagtcaa caacctcttt ctcaagtccc acagcattgt   4920

gcagaaaaca gccatgaact ggcggctctc agcccgcaat gccgcacgca gggactctgt   4980

tctggcagct tccagagact accggaatat cattgagaga ttgcaggaca tcgtctccgc   5040

gctggaggac cgtctcaggc ccctggtgca ggcagagtta tctgtgctcg tggatgttct   5100

ccacagaccc gagctgcttt tcccagagaa cacagacgcc agaaggaaat gtgaaagtgg   5160

cggtttcatt tgcaagttaa taaagcatac aaaacagctg ctagaagaaa atgaagagaa   5220

gctctgcatt aaggtcctac agaccctgag ggaaatgatg accaaagata gaggctatgg   5280

agaaaagggt gaggcgctca ggcaagttct ggtcaaccgt tactatggaa acgtcagacc   5340

ttcgggacga agagagagcc ttaccagctt tggcaatggc ccactgtcag caggaggacc   5400

cggcaagccc gggggaggag ggggaggttc cggatccagc tctatgagca ggggtgagat   5460

gagtctggcc gaggttcagt gtcaccttga caaggagggg gcttccaatc tagttatcga   5520

cctcatcatg aacgcatcca gtgaccgagt gttccatgaa agcattctcc tggccattgc   5580

ccttctggaa ggaggcaaca ccaccatcca gcactccttt ttctgtcgct tgacagaaga   5640

taagaagtca gagaaattct ttaaggtgtt ttatgaccgg atgaaggtgg cccagcaaga   5700

aatcaaagca acagtgacag tgaacaccag tgacttggga aataaaaaga aagacgatga   5760

ggtagacagg gatgccccat cacggaaaaa agctaaagag cccacaacac agataacaga   5820

agaggtccgg gatcagctcc tggaggcctc cgctgccacc aggaaagcct tcaccacttt   5880

caggagggag gctgatcccg acgaccacta ccagcctgga gagggcaccc aggccactgc   5940

cgacaaggcc aaggacgacc tggagatgag cgcggtcatc accatcatgc agcccatcct   6000

ccgcttcctt cagctcctgt gtgaaaacca caaccgagac ctgcagaact tcctccgttg   6060

ccaaaataac aagaccaact acaatttggt atgtgagacc ctgcagtttc tggactgtat   6120

ttgtggaagc acaactggag gccttggtct tctgggcttg tatataaatg aaaagaacgt   6180

agcgcttatc aaccaaaccc tggaaagtct gaccgaatac tgtcaaggac cttgccatga   6240

gaaccagaac tgcatagcca cccatgaatc caatggcatt gacatcatca cagccctgat   6300

cctcaatgat atcaatcctt tgggaaagaa gaggatggac cttgtgttag aactgaagaa   6360

caatgcctcg aagttgctcc tggccatcat ggaaagcagg cacgacagtg aaaacgcaga   6420

gaggatactt tataacatga ggcccaagga actggtggaa gtgatcaaga aagcctacat   6480

gcaaggtgaa gtggaatttg aggatggaga aaacggtgag gatggggcgg cgtcccccag   6540

gaacgtgggg cacaacatct acatattagc ccatcagttg gctcggcata acaaagaact   6600

tcagagcatg ctgaaacctg gtggccaagt ggacggagat gaagccctgg agttttatgc   6660

caagcacacg gcgcagatag agattgtcag attagaccga acaatggaac agatagtctt   6720

tcccgtgccc agcatatgtg aattcctaac caaggagtca aaactacgaa tttactatac   6780

tacagagaga gacgaacaag gcagcaaaat caatgatttc tttctgcggt ctgaagacct   6840

cttcaatgaa atgaattggc agaagaaact gagagcccag cccgtgttgt actggtgtgc   6900

ccgcaacatg tctttctgga gcagcatttc gtttaacctg gccgtcctga tgaacctgct   6960

ggtggcgttt ttctacccgt ttaagggagt ccgaggagga accctggagc cccactggtc   7020

gggactcctg tggacagcca tgctcatctc tctggccatc gtcattgccc tccccaagcc   7080

ccatggcatc cgggccttaa ttgcctccac aattctacga ctgatatttt cagtcgggtt   7140

acaacccacg ttgtttcttc tgggcgcttt caatgtatgc aataaaatca tctttctaat   7200

gagctttgtg ggcaactgtg ggacattcac aagaggctac cgagccatgg ttctggatgt   7260

tgagttcctc tatcatttgt tgtatctggt gatctgtgcc atggggctct ttgtccatga   7320

attcttctac agtctgctgc tttttgattt agtgtacaga gaagagactt tgcttaatgt   7380

cattaaaagt gtcactcgca atggacggtc catcatcctg acagcagttc tggctctgat   7440

cctcgtttac ctgttctcaa tagtgggcta tcttttcttc aaggatgact ttatcttgga   7500

agtagatagg ctgcccaatg aaacagctgt tccagaaacc ggcgagagtt tggcaagcga   7560

gttcctgttc tccgatgtgt gtagggtgga gagtggggag aactgctcct ctcctgcacc   7620

cagagaagag ctggtccctg cagaagagac ggaacaggat aaagagcaca catgtgagac   7680

gctgctgatg tgcattgtca ccgtgctgag tcacgggctg cggagcgggg gtggagtagg   7740

agatgtactc aggaaaccgt ccaaagagga acccctgttt gctgctagag ttatttatga   7800

cctcttgttc ttcttcatgg tcatcatcat tgttcttaac ctgatttttg gggttatcat   7860

tgacactttt gctgacctga ggagtgagaa gcagaagaag gaagagatct tgaagaccac   7920

gtgctttatc tgtggcttgg aaagagacaa gtttgacaac aagactgtca cctttgaaga   7980

gcacatcaag gaagaacaca acatgtggca ctatctgtgc ttcatcgtcc tggtgaaagt   8040

aaaggactcc accgaatata ctgggcctga gagttacgtg gcagaaatga tcaaggaaag   8100

aaaccttgac tggttcccca ggatgagagc catgtcattg gtcagcagtg attctgaagg   8160

agaacagaat gagctgagaa acctgcagga ga                                 8192


<210>  744
<211>  2695
<212>  PRT
<213>  Homosapiens

<400>  744

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met 
                325                 330                 335     


Val Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile 
            340                 345                 350         


Phe Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro 
        355                 360                 365             


Arg Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val 
    370                 375                 380                 


His Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met 
385                 390                 395                 400 


Leu Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala 
                405                 410                 415     


Ile Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn 
            420                 425                 430         


Asp Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly 
        435                 440                 445             


Thr Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp 
    450                 455                 460                 


Leu Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu 
465                 470                 475                 480 


Glu Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg 
                485                 490                 495     


Glu Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe 
            500                 505                 510         


Thr Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp 
        515                 520                 525             


Gln Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val 
    530                 535                 540                 


Leu Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala 
545                 550                 555                 560 


Lys Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala 
                565                 570                 575     


Glu Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu 
            580                 585                 590         


Lys His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg 
        595                 600                 605             


Lys Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val 
    610                 615                 620                 


Ser Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala 
625                 630                 635                 640 


Val Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val 
                645                 650                 655     


Leu Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala 
            660                 665                 670         


Leu Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp 
        675                 680                 685             


Ser Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp 
    690                 695                 700                 


Ala Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg 
705                 710                 715                 720 


Tyr Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu 
                725                 730                 735     


Ala Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg 
            740                 745                 750         


Cys Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys 
        755                 760                 765             


Arg Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val 
    770                 775                 780                 


Thr Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile 
785                 790                 795                 800 


Ala Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys 
                805                 810                 815     


Glu Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp 
            820                 825                 830         


Val Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu 
        835                 840                 845             


Thr Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe 
    850                 855                 860                 


Tyr Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile 
865                 870                 875                 880 


Leu Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala 
                885                 890                 895     


Lys Gly Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly 
            900                 905                 910         


Val Gly Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu 
        915                 920                 925             


Pro Met Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala 
    930                 935                 940                 


Glu Pro Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile 
945                 950                 955                 960 


Ile Glu Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile 
                965                 970                 975     


Ser Cys Leu Leu Cys Ile Phe Lys Arg Glu Phe Asp Glu Ser Asn Ser 
            980                 985                 990         


Gln Thr Ser Glu Thr Ser Ser Gly  Asn Ser Ser Gln Glu  Gly Pro Ser 
        995                 1000                 1005             


Asn Val  Pro Gly Ala Leu Asp  Phe Glu His Ile Glu  Glu Gln Ala 
    1010                 1015                 1020             


Glu Gly  Ile Phe Gly Gly Ser  Glu Glu Asn Thr Pro  Leu Asp Leu 
    1025                 1030                 1035             


Asp Asp  His Gly Gly Arg Thr  Phe Leu Arg Val Leu  Leu His Leu 
    1040                 1045                 1050             


Thr Met  His Asp Tyr Pro Pro  Leu Val Ser Gly Ala  Leu Gln Leu 
    1055                 1060                 1065             


Leu Phe  Arg His Phe Ser Gln  Arg Gln Glu Val Leu  Gln Ala Phe 
    1070                 1075                 1080             


Lys Gln  Val Gln Leu Leu Val  Thr Ser Gln Asp Val  Asp Asn Tyr 
    1085                 1090                 1095             


Lys Gln  Ile Lys Gln Asp Leu  Asp Gln Leu Arg Ser  Ile Val Glu 
    1100                 1105                 1110             


Lys Ser  Glu Leu Trp Val Tyr  Lys Gly Gln Gly Pro  Asp Glu Thr 
    1115                 1120                 1125             


Met Asp  Gly Ala Ser Gly Glu  Asn Glu His Lys Lys  Thr Glu Glu 
    1130                 1135                 1140             


Gly Asn  Asn Lys Pro Gln Lys  His Glu Ser Thr Ser  Ser Tyr Asn 
    1145                 1150                 1155             


Tyr Arg  Val Val Lys Glu Ile  Leu Ile Arg Leu Ser  Lys Leu Cys 
    1160                 1165                 1170             


Val Gln  Glu Ser Ala Ser Val  Arg Lys Ser Arg Lys  Gln Gln Gln 
    1175                 1180                 1185             


Arg Leu  Leu Arg Asn Met Gly  Ala His Ala Val Val  Leu Glu Leu 
    1190                 1195                 1200             


Leu Gln  Ile Pro Tyr Glu Lys  Ala Glu Asp Thr Lys  Met Gln Glu 
    1205                 1210                 1215             


Ile Met  Arg Leu Ala His Glu  Phe Leu Gln Asn Phe  Cys Ala Gly 
    1220                 1225                 1230             


Asn Gln  Gln Asn Gln Ala Leu  Leu His Lys His Ile  Asn Leu Phe 
    1235                 1240                 1245             


Leu Asn  Pro Gly Ile Leu Glu  Ala Val Thr Met Gln  His Ile Phe 
    1250                 1255                 1260             


Met Asn  Asn Phe Gln Leu Cys  Ser Glu Ile Asn Glu  Arg Val Val 
    1265                 1270                 1275             


Gln His  Phe Val His Cys Ile  Glu Thr His Gly Arg  Asn Val Gln 
    1280                 1285                 1290             


Tyr Ile  Lys Phe Leu Gln Thr  Ile Val Lys Ala Glu  Gly Lys Phe 
    1295                 1300                 1305             


Ile Lys  Lys Cys Gln Asp Met  Val Met Ala Glu Leu  Val Asn Ser 
    1310                 1315                 1320             


Gly Glu  Asp Val Leu Val Phe  Tyr Asn Asp Arg Ala  Ser Phe Gln 
    1325                 1330                 1335             


Thr Leu  Ile Gln Met Met Arg  Ser Glu Arg Asp Arg  Met Asp Glu 
    1340                 1345                 1350             


Asn Ser  Pro Leu Met Tyr His  Ile His Leu Val Glu  Leu Leu Ala 
    1355                 1360                 1365             


Val Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1370                 1375                 1380             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Glu 
    1385                 1390                 1395             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Ile Asn  Phe Leu Asn 
    1400                 1405                 1410             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1415                 1420                 1425             


Ser Asn  His Met Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Ile 
    1430                 1435                 1440             


Cys Arg  Ala Cys Asn Asn Thr  Ser Asp Arg Lys His  Ala Asp Ser 
    1445                 1450                 1455             


Ile Leu  Glu Lys Tyr Val Thr  Glu Ile Val Met Ser  Ile Val Thr 
    1460                 1465                 1470             


Thr Phe  Phe Ser Ser Pro Phe  Ser Asp Gln Ser Thr  Thr Leu Gln 
    1475                 1480                 1485             


Thr Arg  Gln Pro Val Phe Val  Gln Leu Leu Gln Gly  Val Phe Arg 
    1490                 1495                 1500             


Val Tyr  His Cys Asn Trp Leu  Met Pro Ser Gln Lys  Ala Ser Val 
    1505                 1510                 1515             


Glu Ser  Cys Ile Arg Val Leu  Ser Asp Val Ala Lys  Ser Arg Ala 
    1520                 1525                 1530             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Asn Leu Phe 
    1535                 1540                 1545             


Leu Lys  Ser His Ser Ile Val  Gln Lys Thr Ala Met  Asn Trp Arg 
    1550                 1555                 1560             


Leu Ser  Ala Arg Asn Ala Ala  Arg Arg Asp Ser Val  Leu Ala Ala 
    1565                 1570                 1575             


Ser Arg  Asp Tyr Arg Asn Ile  Ile Glu Arg Leu Gln  Asp Ile Val 
    1580                 1585                 1590             


Ser Ala  Leu Glu Asp Arg Leu  Arg Pro Leu Val Gln  Ala Glu Leu 
    1595                 1600                 1605             


Ser Val  Leu Val Asp Val Leu  His Arg Pro Glu Leu  Leu Phe Pro 
    1610                 1615                 1620             


Glu Asn  Thr Asp Ala Arg Arg  Lys Cys Glu Ser Gly  Gly Phe Ile 
    1625                 1630                 1635             


Cys Lys  Leu Ile Lys His Thr  Lys Gln Leu Leu Glu  Glu Asn Glu 
    1640                 1645                 1650             


Glu Lys  Leu Cys Ile Lys Val  Leu Gln Thr Leu Arg  Glu Met Met 
    1655                 1660                 1665             


Thr Lys  Asp Arg Gly Tyr Gly  Glu Lys Gly Glu Ala  Leu Arg Gln 
    1670                 1675                 1680             


Val Leu  Val Asn Arg Tyr Tyr  Gly Asn Val Arg Pro  Ser Gly Arg 
    1685                 1690                 1695             


Arg Glu  Ser Leu Thr Ser Phe  Gly Asn Gly Pro Leu  Ser Ala Gly 
    1700                 1705                 1710             


Gly Pro  Gly Lys Pro Gly Gly  Gly Gly Gly Gly Ser  Gly Ser Ser 
    1715                 1720                 1725             


Ser Met  Ser Arg Gly Glu Met  Ser Leu Ala Glu Val  Gln Cys His 
    1730                 1735                 1740             


Leu Asp  Lys Glu Gly Ala Ser  Asn Leu Val Ile Asp  Leu Ile Met 
    1745                 1750                 1755             


Asn Ala  Ser Ser Asp Arg Val  Phe His Glu Ser Ile  Leu Leu Ala 
    1760                 1765                 1770             


Ile Ala  Leu Leu Glu Gly Gly  Asn Thr Thr Ile Gln  His Ser Phe 
    1775                 1780                 1785             


Phe Cys  Arg Leu Thr Glu Asp  Lys Lys Ser Glu Lys  Phe Phe Lys 
    1790                 1795                 1800             


Val Phe  Tyr Asp Arg Met Lys  Val Ala Gln Gln Glu  Ile Lys Ala 
    1805                 1810                 1815             


Thr Val  Thr Val Asn Thr Ser  Asp Leu Gly Asn Lys  Lys Lys Asp 
    1820                 1825                 1830             


Asp Glu  Val Asp Arg Asp Ala  Pro Ser Arg Lys Lys  Ala Lys Glu 
    1835                 1840                 1845             


Pro Thr  Thr Gln Ile Thr Glu  Glu Val Arg Asp Gln  Leu Leu Glu 
    1850                 1855                 1860             


Ala Ser  Ala Ala Thr Arg Lys  Ala Phe Thr Thr Phe  Arg Arg Glu 
    1865                 1870                 1875             


Ala Asp  Pro Asp Asp His Tyr  Gln Pro Gly Glu Gly  Thr Gln Ala 
    1880                 1885                 1890             


Thr Ala  Asp Lys Ala Lys Asp  Asp Leu Glu Met Ser  Ala Val Ile 
    1895                 1900                 1905             


Thr Ile  Met Gln Pro Ile Leu  Arg Phe Leu Gln Leu  Leu Cys Glu 
    1910                 1915                 1920             


Asn His  Asn Arg Asp Leu Gln  Asn Phe Leu Arg Cys  Gln Asn Asn 
    1925                 1930                 1935             


Lys Thr  Asn Tyr Asn Leu Val  Cys Glu Thr Leu Gln  Phe Leu Asp 
    1940                 1945                 1950             


Cys Ile  Cys Gly Ser Thr Thr  Gly Gly Leu Gly Leu  Leu Gly Leu 
    1955                 1960                 1965             


Tyr Ile  Asn Glu Lys Asn Val  Ala Leu Ile Asn Gln  Thr Leu Glu 
    1970                 1975                 1980             


Ser Leu  Thr Glu Tyr Cys Gln  Gly Pro Cys His Glu  Asn Gln Asn 
    1985                 1990                 1995             


Cys Ile  Ala Thr His Glu Ser  Asn Gly Ile Asp Ile  Ile Thr Ala 
    2000                 2005                 2010             


Leu Ile  Leu Asn Asp Ile Asn  Pro Leu Gly Lys Lys  Arg Met Asp 
    2015                 2020                 2025             


Leu Val  Leu Glu Leu Lys Asn  Asn Ala Ser Lys Leu  Leu Leu Ala 
    2030                 2035                 2040             


Ile Met  Glu Ser Arg His Asp  Ser Glu Asn Ala Glu  Arg Ile Leu 
    2045                 2050                 2055             


Tyr Asn  Met Arg Pro Lys Glu  Leu Val Glu Val Ile  Lys Lys Ala 
    2060                 2065                 2070             


Tyr Met  Gln Gly Glu Val Glu  Phe Glu Asp Gly Glu  Asn Gly Glu 
    2075                 2080                 2085             


Asp Gly  Ala Ala Ser Pro Arg  Asn Val Gly His Asn  Ile Tyr Ile 
    2090                 2095                 2100             


Leu Ala  His Gln Leu Ala Arg  His Asn Lys Glu Leu  Gln Ser Met 
    2105                 2110                 2115             


Leu Lys  Pro Gly Gly Gln Val  Asp Gly Asp Glu Ala  Leu Glu Phe 
    2120                 2125                 2130             


Tyr Ala  Lys His Thr Ala Gln  Ile Glu Ile Val Arg  Leu Asp Arg 
    2135                 2140                 2145             


Thr Met  Glu Gln Ile Val Phe  Pro Val Pro Ser Ile  Cys Glu Phe 
    2150                 2155                 2160             


Leu Thr  Lys Glu Ser Lys Leu  Arg Ile Tyr Tyr Thr  Thr Glu Arg 
    2165                 2170                 2175             


Asp Glu  Gln Gly Ser Lys Ile  Asn Asp Phe Phe Leu  Arg Ser Glu 
    2180                 2185                 2190             


Asp Leu  Phe Asn Glu Met Asn  Trp Gln Lys Lys Leu  Arg Ala Gln 
    2195                 2200                 2205             


Pro Val  Leu Tyr Trp Cys Ala  Arg Asn Met Ser Phe  Trp Ser Ser 
    2210                 2215                 2220             


Ile Ser  Phe Asn Leu Ala Val  Leu Met Asn Leu Leu  Val Ala Phe 
    2225                 2230                 2235             


Phe Tyr  Pro Phe Lys Gly Val  Arg Gly Gly Thr Leu  Glu Pro His 
    2240                 2245                 2250             


Trp Ser  Gly Leu Leu Trp Thr  Ala Met Leu Ile Ser  Leu Ala Ile 
    2255                 2260                 2265             


Val Ile  Ala Leu Pro Lys Pro  His Gly Ile Arg Ala  Leu Ile Ala 
    2270                 2275                 2280             


Ser Thr  Ile Leu Arg Leu Ile  Phe Ser Val Gly Leu  Gln Pro Thr 
    2285                 2290                 2295             


Leu Phe  Leu Leu Gly Ala Phe  Asn Val Cys Asn Lys  Ile Ile Phe 
    2300                 2305                 2310             


Leu Met  Ser Phe Val Gly Asn  Cys Gly Thr Phe Thr  Arg Gly Tyr 
    2315                 2320                 2325             


Arg Ala  Met Val Leu Asp Val  Glu Phe Leu Tyr His  Leu Leu Tyr 
    2330                 2335                 2340             


Leu Val  Ile Cys Ala Met Gly  Leu Phe Val His Glu  Phe Phe Tyr 
    2345                 2350                 2355             


Ser Leu  Leu Leu Phe Asp Leu  Val Tyr Arg Glu Glu  Thr Leu Leu 
    2360                 2365                 2370             


Asn Val  Ile Lys Ser Val Thr  Arg Asn Gly Arg Ser  Ile Ile Leu 
    2375                 2380                 2385             


Thr Ala  Val Leu Ala Leu Ile  Leu Val Tyr Leu Phe  Ser Ile Val 
    2390                 2395                 2400             


Gly Tyr  Leu Phe Phe Lys Asp  Asp Phe Ile Leu Glu  Val Asp Arg 
    2405                 2410                 2415             


Leu Pro  Asn Glu Thr Ala Val  Pro Glu Thr Gly Glu  Ser Leu Ala 
    2420                 2425                 2430             


Ser Glu  Phe Leu Phe Ser Asp  Val Cys Arg Val Glu  Ser Gly Glu 
    2435                 2440                 2445             


Asn Cys  Ser Ser Pro Ala Pro  Arg Glu Glu Leu Val  Pro Ala Glu 
    2450                 2455                 2460             


Glu Thr  Glu Gln Asp Lys Glu  His Thr Cys Glu Thr  Leu Leu Met 
    2465                 2470                 2475             


Cys Ile  Val Thr Val Leu Ser  His Gly Leu Arg Ser  Gly Gly Gly 
    2480                 2485                 2490             


Val Gly  Asp Val Leu Arg Lys  Pro Ser Lys Glu Glu  Pro Leu Phe 
    2495                 2500                 2505             


Ala Ala  Arg Val Ile Tyr Asp  Leu Leu Phe Phe Phe  Met Val Ile 
    2510                 2515                 2520             


Ile Ile  Val Leu Asn Leu Ile  Phe Gly Val Ile Ile  Asp Thr Phe 
    2525                 2530                 2535             


Ala Asp  Leu Arg Ser Glu Lys  Gln Lys Lys Glu Glu  Ile Leu Lys 
    2540                 2545                 2550             


Thr Thr  Cys Phe Ile Cys Gly  Leu Glu Arg Asp Lys  Phe Asp Asn 
    2555                 2560                 2565             


Lys Thr  Val Thr Phe Glu Glu  His Ile Lys Glu Glu  His Asn Met 
    2570                 2575                 2580             


Trp His  Tyr Leu Cys Phe Ile  Val Leu Val Lys Val  Lys Asp Ser 
    2585                 2590                 2595             


Thr Glu  Tyr Thr Gly Pro Glu  Ser Tyr Val Ala Glu  Met Ile Lys 
    2600                 2605                 2610             


Glu Arg  Asn Leu Asp Trp Phe  Pro Arg Met Arg Ala  Met Ser Leu 
    2615                 2620                 2625             


Val Ser  Ser Asp Ser Glu Gly  Glu Gln Asn Glu Leu  Arg Asn Leu 
    2630                 2635                 2640             


Gln Glu  Lys Leu Glu Ser Thr  Met Lys Leu Val Thr  Asn Leu Ser 
    2645                 2650                 2655             


Gly Gln  Leu Ser Glu Leu Lys  Asp Gln Met Thr Glu  Gln Arg Lys 
    2660                 2665                 2670             


Gln Lys  Gln Arg Ile Gly Leu  Leu Gly His Pro Pro  His Met Asn 
    2675                 2680                 2685             


Val Asn  Pro Gln Gln Pro Ala  
    2690                 2695 


<210>  745
<211>  3008
<212>  DNA
<213>  Homosapiens

<400>  745
gggtgccgac ggcggcgccg ggacgggcgt ggggggtagg gcgagtcata tgatccgctc     60

ggcttcctgg gtctggctgc tgccgcccgc cggtgtccgc ccgtgtcgcg ccggggcacc    120

aaggagccgt tggagggtcc gggcggaggc ccgctcgtgt ggaagtcgtc gacgccgccg    180

ctcgtccgtc ctcccgtccg ttctcgctcc cggccgccat catgctggcg ctcatctccc    240

gcctgctgga ctggttccgt tcgctcttct ggaaggaaga gatggagctg acgctcgtgg    300

ggctgcagta ctcgggcaag accaccttcg tcaatgtcat cgcgtcaggt caattcagtg    360

aagatatgat acccacagtg ggcttcaaca tgaggaaggt aactaaaggt aacgtcacaa    420

taaagatctg ggacatagga ggacaacccc gatttcgaag catgtgggag cggtattgca    480

gaggagtcaa tgctattgtt tacatgatag atgctgcaga tcgtgaaaag atagaagctt    540

cccgaaatga gctacataat cttctagata aaccacagtt acaaggaatt ccagtgctag    600

tgcttggaaa caagagagat cttcctaatg ccttggatga gaaacagcta attgaaaaaa    660

tgaatctgtc tgctattcag gatagagaaa tttgctgcta ttcaatttct tgcaaagaaa    720

aggataatat agatatcaca cttcagtggc ttattcagca ttcaaaatct agaagaagct    780

gaagcatctc ctgaagtctt ccagtccttc ttggctataa tcctagaatt attgtccgtt    840

cctctgaagt aattcccaga atacggtcct tcctaaaccc cagaaattgc ctttttcaga    900

gtttatttct catgtgcact gctgaagatg aatatcccta atccttcata aagaatcagc    960

tagagttgtc atgataaagt cagcacacac aaaaaggctt cttacacata cctgtcttaa   1020

accatgtgta gagctttaaa aacagaaaaa aaaccccata tacttatgac catcttaaat   1080

caagaaaatt gcatatttcc attctggtct ttctgggcca gatttttata ttggttttca   1140

gtaaatgtct atctataata tttcattata gagtccagta gcttaatact gacactgact   1200

tgatacagca tgaagtttct agtgccacac acagtattta gaaaaccttt aggcgtgaat   1260

gactcatgtg ggatatatgt aaacataatg tttattttat ctcacaaatg catgtgaaat   1320

gtataattac atcttaggaa tccaaaatgg tctgcagaga gtgagcggag gcaccagatc   1380

aatgttggtt ctttgcactg gtgagattct gcctgatgaa tattaaagat atcctgcttt   1440

ctgagaactc tatcaccaga tggcagttgg gatatgggag gaactaaagc atcctgtttt   1500

gtatctgtcc agatcattat ttctgtctct tgttttttct tcctggttca ggatactttt   1560

ttaaggggtt gagaattgaa gattttccaa aagcgttcat gaatttagag cattccaccc   1620

aatataataa aacctgttaa gaatgtcagt ctttgttcaa acatctgttt gttctatctc   1680

cagtcattaa atcagtgctg ctgcatgaca ctcttaactc ctgacttttt atatccagtc   1740

ataaagttga ctttcagcac aaaagatact tataaacaaa taaaaaattt ttatttttct   1800

ctcttactga tgtaagcttt ggcactcttt tgactggtgc cattagacat cttgattatt   1860

gtgacaactc tagacctgcc tgctttatct aatgtaatca tgctcaatgt ctacaggttg   1920

tttaataatc agtcacacag agaactgagg aactgatgct gtttgtttgc ttctatgata   1980

cagagatgtc taaaaacttc aaatggacat gttttgtagt ttagcgactt ccgtatacat   2040

aaagggacat attaatactg gttcatttgt aaattattat tcatatagac cactgtagta   2100

gataaaactc tatggtacac ctgcttatgt gttgcctcac actgtgtgtg attttgtttc   2160

ttttgttaag cagcacttat gtagactgca tttccaaatg tgttgagcac tcagagtgta   2220

gtcaacagta agttctttta atgaatatca gttttaattt atagactgcc atggccttaa   2280

aaatattctg tacaatatac tgcactgtgt tgcacagaca ctacttgctt ttctccattc   2340

atatttttat gagtagaatc tgggctttta aatttctctt cttattcttt gaagcatgtt   2400

gcatactacc ctggtgggat ggatggttct gtaaatgaag ggatatttaa acttgctact   2460

gttgttcaac accattaatg gtcagtgtga accattacaa agaatgtggc aacttgcttg   2520

tgcctaaaag gaggaattgg aactagaatg tgtgactctg tggggactgc ataggtttgt   2580

taattgacct atagctaaac cttaatgtgt ttgtgtgtct atacattgct ttccgcattt   2640

caagacatcc agacgctatt accaacattt tcctgtgcat taacctctgc atgtgaaaac   2700

ttttaacagt tactgaacta tgtaaatatg tgaatttttt tatttaggtg gatgcatttt   2760

ttgtctgttt actgctcttc tcagctttat tcaataaact tgcattttaa gggttgtatt   2820

ggcaatttta acttaaaatg tgcatcatga tggaaggtgc agactttttt ggaagtttcc   2880

gagaggaggg tctatagacc atttgtcaga aatcagatca gccctcaaag aatggggtct   2940

gtgggctagt taaaatagaa ataaactttt aaaatatcca cagaaaaaaa aaaaaaaaaa   3000

aaaaaaaa                                                            3008


<210>  746
<211>  186
<212>  PRT
<213>  Homosapiens

<400>  746

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Val Leu Val Leu 
        115                 120                 125             


Gly Asn Lys Arg Asp Leu Pro Asn Ala Leu Asp Glu Lys Gln Leu Ile 
    130                 135                 140                 


Glu Lys Met Asn Leu Ser Ala Ile Gln Asp Arg Glu Ile Cys Cys Tyr 
145                 150                 155                 160 


Ser Ile Ser Cys Lys Glu Lys Asp Asn Ile Asp Ile Thr Leu Gln Trp 
                165                 170                 175     


Leu Ile Gln His Ser Lys Ser Arg Arg Ser 
            180                 185     


<210>  747
<211>  6072
<212>  DNA
<213>  Homosapiens

<400>  747
ggtggtcggc ggggaggccc ccgcgcttta aaataatgcc cgcggcgccc gcgcgaccat     60

gcaatggcga gcgctcgtcc tggggctggt gctcctccgg cttggcctcc atggagtatt    120

gtggctcgtc ttcgggctgg ggcccagcat gggcttctac cagcgctttc cgctcagctt    180

cggcttccag cgtctgagga gccccgacgg ccccgcgtcg cccacctcgg ggcccgtggg    240

ccggcctggg ggggtatccg ggccgtcgtg gctgcagccg ccggggaccg gggcagcgca    300

gagcccgcgc aaggctccgc ggcgtcctgg gccggggatg tgcggcccag ccaactgggg    360

ctacgtgctg ggcggccggg gccgcggccc ggacgagtac gagaagcgct acagcggcgc    420

cttccctccg cagctgcgtg cccagatgcg cgacctggca cggggcatgt tcgtctttgg    480

ctacgacaac tacatggctc acgccttccc ccaggacgag ctcaacccca tccactgccg    540

cggccgtggg cccgaccgcg gggacccttc aaatctgaac atcaatgatg tactagggaa    600

ctactcattg actcttgttg atgcattgga tacacttgca ataatgggaa attcatccga    660

gttccagaaa gcagtcaagt tagtgatcaa cacagtttca tttgacaaag attccaccgt    720

ccaagtcttt gaggccacga taagggtcct gggaagcctc ctttctgctc acagaataat    780

aactgactcc aagcagccct ttggtgacat gacaattaag gactatgata atgagttgtt    840

atacatggcc catgacctgg cggtgcggct cctccctgct tttgaaaaca ccaagacagg    900

gattccatat cctcgggtga atctaaagac aggagttcct cctgacacca ataatgagac    960

atgcacagcg ggagccggtt ccctcctggt ggaatttggg attctgagtc gactcctggg   1020

ggactccaca tttgagtggg tggccagacg agcagtgaaa gccctttgga acctccggag   1080

caatgataca ggattactag gcaatgtcgt gaacattcag acgggccact gggttggaaa   1140

gcagagtggc ctgggtgccg ggctggactc cttctatgaa tacctcttga aatcttacat   1200

tctctttgga gaaaaagaag acctagaaat gtttaatgct gcatatcaga gtattcagaa   1260

ctacttaaga agagggcggg aagcctgcaa tgaaggagaa ggagaccctc cactctatgt   1320

caacgtgaac atgttcagtg ggcagctgat gaacacctgg attgactctc tgcaggcctt   1380

tttccctgga ctgcaggtgc tgataggaga tgtggaagat gccatctgcc ttcatgcctt   1440

ctactatgcc atatggaaac gatatggtgc cctccctgag agatataact ggcagctgca   1500

ggcccctgac gttctcttct acccactgag accagagtta gtggaatcca catatctcct   1560

ctaccaggca accaagaatc ccttctacct ccatgtagga atggatattc tgcagagtct   1620

ggaaaagtac acaaaagtca agtgtgggta cgccacgctg catcacgtca ttgacaagtc   1680

cacagaagac cggatggaga gcttctttct cagtgagacc tgtaaatatt tgtatctgct   1740

gtttgatgaa gacaatccag tacacaagtc tggaaccaga tacatgttca caacagaggg   1800

acacattgta tctgtggatg agcatcttcg ggaattgcca tggaaggaat tcttctctga   1860

agagggaggg caggaccaag ggggaaagtc tgtgcacagg ccgaaacctc atgagttaaa   1920

agtcatcaac tccagctcca actgcaatcg tgtacctgat gagaggaggt actccctgcc   1980

cttaaagagc atctacatgc gacagattga ccagatggtt ggtttgattt gatctgctct   2040

ctgtgaggcc tcatcttgaa ccagacctta acgaccaaac ccagaccatg ccaaagtcca   2100

gtctgaaatg aaaggggaca gaagtcttgc tgtccatggt ggtgtaggaa tttctgtgca   2160

acacctcacc acgtctggtt aatccttgca cacttcagtg tttctctcct gttcaataaa   2220

atgccctgtt aaggatataa tttgaagtga gaagatacat ggaaattgcc ctcttatgac   2280

atgttgatgt tataagcaca atagatgggg catctttgga ttgatgttca cagctttata   2340

cttcagaacc taagtctctt cactttgctg gcacctgcta tactggagta ttgctatgtc   2400

tttaaaaaat ttttttttat tatattttat ttttttgaga cagggtcttg atattttttt   2460

gggacagggt tacctgggct caagtgatcc ttctgcctca gcctcccgag tagctgggat   2520

tacaggtgag caccactgta cctggctagc tacttctttg ttagaggatt gagaatgaaa   2580

tttctgcaaa agggcccatg gttcatttgg tatccctatt taattgcatt gaaaatgtca   2640

tcctttctgt tgttagataa ttggggtctt cccctgatat ccaaccgtga ttttggatca   2700

catgggagaa aaagtcatcc agtttttcat gtttgcctca agtaatcttt acagtgttac   2760

aaattatttg cttaagaaga atggtcttaa ccagaattct taacagatag tctcttaggt   2820

tattatgtta tggtctaaga ggttaactga catcttttgg atggtatttt gcattttgaa   2880

tatgaactta cctgaggaac tcccatagtt ccagaatcag gtgcctttta gggagagaac   2940

aatacctaag attgtctgag cttccatctt tctcatattt cctaagcaag gattctcact   3000

tatgaccata tttgggttag agttctgttt tgtttctgtt ttctgtgtct agtgccaatt   3060

agctaaatca gggagaaaga aatgatcaca tgacttttag catccttgag ccatttctct   3120

gtgtaataca ggctttagat tagtgcctta tattggtttt ggtttggggc actggatgtc   3180

gcagctactg ctatggtttc aggaggcctg tttagccaca tggtgagacc gtggtgaaag   3240

ggggatggaa attgcttggc cagtctttgc ctttcatcct gtaaaagtaa gcatgtagaa   3300

ggaggaagtt gtgctaaaat gcctttgttt ttttgttatt attttcttag ccagaacatc   3360

tctctttgaa ctcacactga tacacacctg ctactcttac acagtgcagc agggctgact   3420

cttagtctgg cttccatgaa gcgtcatggg tggaaacgca ttctagtaaa aaaggtagga   3480

aatccctaaa acttccagcc tcacatagca cggttctcac ctgtcactgt tttcccacct   3540

ctaaggattt catgtacatc ttttcaaagc tagaaataag cactgtctaa gtttatgttg   3600

catttttagt caaaagggag aaatcttatt ccttcttgaa aattttaagt gttatggttt   3660

tatatagttc agttctttga gatttttgaa aagagtattt tcagtaataa acgtgccatc   3720

tctatctctt aaacatttat tacaacaatt gttttaaaat agaaaaaata aaatgcttct   3780

attttacctt ttttcatttc agaagcatta ttctgtttat taacagtgtc ccatctactg   3840

aatagaaaac tttgagaata atatatatat atattttaaa tgttttcact gactcattga   3900

aaatgttaat tacacacaca tgcatgcatg cacacacgag catacttgta cctttgtctc   3960

tgggcaaaca ggtgggactg ttagtgaccc atttgggaaa atagagcatc tcagagaagg   4020

aggtgagttc ttcctgcctg tgatttctct tggcgctccc ctcctctccc gctctggctt   4080

ctgtggcggc agtggtgggt aagcactcca gtgttctctt aatgaggcac tttgcctgtc   4140

actcgagcaa gcctgggtgt tccttcctcc tcatgctcct ggaataggga atagggatct   4200

catgcttgca aactacacaa tgctgcaggt gcttcccagg ggccacaggc tgtcaggaaa   4260

cgtgttttat gttaagtcac aaacccactt gacttctggg tactggaatt aataccagtg   4320

ggtgagactg agggtgagtg agttagtaca tattaatcct ggttgttgag cttccagact   4380

accccgtcca aagtttgatg ctatgtagtc agtggtttgt ggggctggat gccagaaggt   4440

tctttgagcc agtttcaaag gttacttgtt tttttttttt tttttttaag tcagaatgtt   4500

aacagctgtg atatatcctg cagggctttt gcagtttctt ctgttctgtg ttctgaaatc   4560

ctgggtagag aatggctgag gaggagatta ccagagaagt tgctttgctc agtgctttgc   4620

cccaggattg cctcaaatct gagtggactt catcctttgc ggcggctctg agcctggccc   4680

atcttcctat tcccacgtgt agctagtgtc tagtgtcagc tttgctcaat gtggtggaaa   4740

cattttgcag aactgttgta gaaagctgcc ttatagttgg cttgacaaag cataattctc   4800

tcataacaaa ctttcaaatc attacagtag cttagctact ttagttgatg tgaccgagga   4860

atcccttcta gaatcatagg tggcaaggga gggtttgcta gctctccatt tgcactggcc   4920

attgtgaaaa accagcttct gtattcaaat ctttccttca tttttttaaa tttttttttt   4980

ggcagcgctt gtgctggaac ttactcattg taactgaatc ctcagggctt ttcttgtttt   5040

agatcatgga ctgtgcacgt gacacttaaa taattttcta tgtatttaaa gaaaaatgca   5100

ccaggatggt gtctgtgcac gtgactatta gaggagcgtc tgtagaagta cctggtttgg   5160

tcagtgcagt tgtgcaatct gagggccttg tttcctcctc ccctttcccc ttctccccac   5220

caaaggaaaa tatccctctt aatgatttcg tagttcagtt tactgaatga ttaccacctg   5280

taattcctct ttggattgtg tagactcaac atgagacatt cctttctgct ttctggaggg   5340

caccaggggc ctttctcttt gataaatttt ttttgtctgt tgacaaaaac aaaaatcttt   5400

tttcaaatgt agtgctggtg aaaaggtagg gctgagtgat taccttagcc acagggtggc   5460

tgagcaggaa ctttagaaga aaatcctgag ctttcctgtc cattcccagc atccagctcc   5520

tattctagtg cctcttccct gcagggcagg gaccccttgg gaaatcgagg aggtgggacg   5580

ggctgggccc tgtgtcccag gtttcacagg gctcagggtt atgctcccgc ttgaatctgg   5640

acgtgaatct ggtaaaaata tcaagtacct gtggaactcc ctgattctat accctcttcc   5700

ttctttctgc aaggcagagg aataatattt ttaaaggtta ttttgtttta gttttaaata   5760

gcaaaacaca agctgcattt ttatttattt tgcataagaa aggtaaatct ttttacaaaa   5820

aaaagtatag agttggaaac tctgggaaaa cttacggaaa tacacaaatg cttctctgta   5880

atgtgcaata tgctttgcaa ctgtagatga tattttatgt ttaatctgta aataagaaat   5940

gtatttaaat taaaagggat ctttttgtaa aaggaccaaa tgttctttta taaatgtaat   6000

aaggaatatc ttgctcttta aaatttatta ggatttttat gagtaatttt tattaaaaga   6060

tttctttttt tg                                                       6072


<210>  748
<211>  657
<212>  PRT
<213>  Homosapiens

<400>  748

Met Gln Trp Arg Ala Leu Val Leu Gly Leu Val Leu Leu Arg Leu Gly 
1               5                   10                  15      


Leu His Gly Val Leu Trp Leu Val Phe Gly Leu Gly Pro Ser Met Gly 
            20                  25                  30          


Phe Tyr Gln Arg Phe Pro Leu Ser Phe Gly Phe Gln Arg Leu Arg Ser 
        35                  40                  45              


Pro Asp Gly Pro Ala Ser Pro Thr Ser Gly Pro Val Gly Arg Pro Gly 
    50                  55                  60                  


Gly Val Ser Gly Pro Ser Trp Leu Gln Pro Pro Gly Thr Gly Ala Ala 
65                  70                  75                  80  


Gln Ser Pro Arg Lys Ala Pro Arg Arg Pro Gly Pro Gly Met Cys Gly 
                85                  90                  95      


Pro Ala Asn Trp Gly Tyr Val Leu Gly Gly Arg Gly Arg Gly Pro Asp 
            100                 105                 110         


Glu Tyr Glu Lys Arg Tyr Ser Gly Ala Phe Pro Pro Gln Leu Arg Ala 
        115                 120                 125             


Gln Met Arg Asp Leu Ala Arg Gly Met Phe Val Phe Gly Tyr Asp Asn 
    130                 135                 140                 


Tyr Met Ala His Ala Phe Pro Gln Asp Glu Leu Asn Pro Ile His Cys 
145                 150                 155                 160 


Arg Gly Arg Gly Pro Asp Arg Gly Asp Pro Ser Asn Leu Asn Ile Asn 
                165                 170                 175     


Asp Val Leu Gly Asn Tyr Ser Leu Thr Leu Val Asp Ala Leu Asp Thr 
            180                 185                 190         


Leu Ala Ile Met Gly Asn Ser Ser Glu Phe Gln Lys Ala Val Lys Leu 
        195                 200                 205             


Val Ile Asn Thr Val Ser Phe Asp Lys Asp Ser Thr Val Gln Val Phe 
    210                 215                 220                 


Glu Ala Thr Ile Arg Val Leu Gly Ser Leu Leu Ser Ala His Arg Ile 
225                 230                 235                 240 


Ile Thr Asp Ser Lys Gln Pro Phe Gly Asp Met Thr Ile Lys Asp Tyr 
                245                 250                 255     


Asp Asn Glu Leu Leu Tyr Met Ala His Asp Leu Ala Val Arg Leu Leu 
            260                 265                 270         


Pro Ala Phe Glu Asn Thr Lys Thr Gly Ile Pro Tyr Pro Arg Val Asn 
        275                 280                 285             


Leu Lys Thr Gly Val Pro Pro Asp Thr Asn Asn Glu Thr Cys Thr Ala 
    290                 295                 300                 


Gly Ala Gly Ser Leu Leu Val Glu Phe Gly Ile Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Gly Asp Ser Thr Phe Glu Trp Val Ala Arg Arg Ala Val Lys Ala Leu 
                325                 330                 335     


Trp Asn Leu Arg Ser Asn Asp Thr Gly Leu Leu Gly Asn Val Val Asn 
            340                 345                 350         


Ile Gln Thr Gly His Trp Val Gly Lys Gln Ser Gly Leu Gly Ala Gly 
        355                 360                 365             


Leu Asp Ser Phe Tyr Glu Tyr Leu Leu Lys Ser Tyr Ile Leu Phe Gly 
    370                 375                 380                 


Glu Lys Glu Asp Leu Glu Met Phe Asn Ala Ala Tyr Gln Ser Ile Gln 
385                 390                 395                 400 


Asn Tyr Leu Arg Arg Gly Arg Glu Ala Cys Asn Glu Gly Glu Gly Asp 
                405                 410                 415     


Pro Pro Leu Tyr Val Asn Val Asn Met Phe Ser Gly Gln Leu Met Asn 
            420                 425                 430         


Thr Trp Ile Asp Ser Leu Gln Ala Phe Phe Pro Gly Leu Gln Val Leu 
        435                 440                 445             


Ile Gly Asp Val Glu Asp Ala Ile Cys Leu His Ala Phe Tyr Tyr Ala 
    450                 455                 460                 


Ile Trp Lys Arg Tyr Gly Ala Leu Pro Glu Arg Tyr Asn Trp Gln Leu 
465                 470                 475                 480 


Gln Ala Pro Asp Val Leu Phe Tyr Pro Leu Arg Pro Glu Leu Val Glu 
                485                 490                 495     


Ser Thr Tyr Leu Leu Tyr Gln Ala Thr Lys Asn Pro Phe Tyr Leu His 
            500                 505                 510         


Val Gly Met Asp Ile Leu Gln Ser Leu Glu Lys Tyr Thr Lys Val Lys 
        515                 520                 525             


Cys Gly Tyr Ala Thr Leu His His Val Ile Asp Lys Ser Thr Glu Asp 
    530                 535                 540                 


Arg Met Glu Ser Phe Phe Leu Ser Glu Thr Cys Lys Tyr Leu Tyr Leu 
545                 550                 555                 560 


Leu Phe Asp Glu Asp Asn Pro Val His Lys Ser Gly Thr Arg Tyr Met 
                565                 570                 575     


Phe Thr Thr Glu Gly His Ile Val Ser Val Asp Glu His Leu Arg Glu 
            580                 585                 590         


Leu Pro Trp Lys Glu Phe Phe Ser Glu Glu Gly Gly Gln Asp Gln Gly 
        595                 600                 605             


Gly Lys Ser Val His Arg Pro Lys Pro His Glu Leu Lys Val Ile Asn 
    610                 615                 620                 


Ser Ser Ser Asn Cys Asn Arg Val Pro Asp Glu Arg Arg Tyr Ser Leu 
625                 630                 635                 640 


Pro Leu Lys Ser Ile Tyr Met Arg Gln Ile Asp Gln Met Val Gly Leu 
                645                 650                 655     


Ile 
    


<210>  749
<211>  1270
<212>  DNA
<213>  Homosapiens

<400>  749
ctctgcctgt gcgaccgccg cccacccgag cctatctggg ctgcgtcttc tcgccgctgc     60

tcttcgtggc ccaacgcccc aatccttgcg tgtgcttgca gtcccacccc acactcagcc    120

ttgtgtccct cgatccagtc tccgacttcc atttcccacc ctaaaccgcc tacccggtgt    180

ctgttccccg cccggttgtc ctcgccctgc tgcgctgagt gtcccctgtt agcctcgacc    240

ccatggcgct gcagacgctg cagagctcgt gggtgacctt ccgcaagatc ctgtctcact    300

tccccgagga gctgagtctg gctttcgtct acggctccgg ggtgtaccgc caggcagggc    360

cgagttcaga ccagaagaat gctatgctgg actttgtgtt cacagtagat gaccctgtcg    420

catggcattc aaagaacctg aagaaaaatt ggagtcacta ctctttccta aaagttttag    480

ggcccaagat tatcacgtcc atccagaata actatggcgc tggagtttac tacaattcat    540

tgatcatgtg taatggtagg cttatcaaat atggagttat tagcactaac gttctgattg    600

aagatctcct caactggaat aacttataca ttgctggacg actccaaaaa ccggtgaaaa    660

ttatctcagt gaacgaggat gtcactctta gatcagccct cgatagaaat ctgaagagtg    720

ctgtgaccgc tgctttcctc atgctccccg aaagcttttc tgaagaagac ctcttcatag    780

agattgccgg tctctcctat tcaggtgact ttcggatggt ggttggagaa gataaaacaa    840

aagtgttgaa tattgtgaag cccaatatag cccactttcg agagctctat ggcagcatac    900

tacaggaaaa tcctcaagtg gtgtataaaa gccagcaagg ctggctggag atagataaaa    960

gcccagaagg acagttcact cagctgatga cattgcccaa aaccttacag caacagataa   1020

atcatattat ggaccctcct ggaaaaaaca gagatgtgga agaaacttta ttccaagtgg   1080

ctcatgatcc cgactgtgga gatgtggtgc gactaggcct gaagaagtca gtgatttata   1140

gttcactaaa actgcacaaa atgtggaaag ggtggctgag gaaaacatcc tgattttgct   1200

tgcttttata tatgttatgt gtagatgaat aaagtgtttg atcctttttg acaaaaaaaa   1260

aaaaaaaaaa                                                          1270


<210>  750
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  750

Met Ala Leu Gln Thr Leu Gln Ser Ser Trp Val Thr Phe Arg Lys Ile 
1               5                   10                  15      


Leu Ser His Phe Pro Glu Glu Leu Ser Leu Ala Phe Val Tyr Gly Ser 
            20                  25                  30          


Gly Val Tyr Arg Gln Ala Gly Pro Ser Ser Asp Gln Lys Asn Ala Met 
        35                  40                  45              


Leu Asp Phe Val Phe Thr Val Asp Asp Pro Val Ala Trp His Ser Lys 
    50                  55                  60                  


Asn Leu Lys Lys Asn Trp Ser His Tyr Ser Phe Leu Lys Val Leu Gly 
65                  70                  75                  80  


Pro Lys Ile Ile Thr Ser Ile Gln Asn Asn Tyr Gly Ala Gly Val Tyr 
                85                  90                  95      


Tyr Asn Ser Leu Ile Met Cys Asn Gly Arg Leu Ile Lys Tyr Gly Val 
            100                 105                 110         


Ile Ser Thr Asn Val Leu Ile Glu Asp Leu Leu Asn Trp Asn Asn Leu 
        115                 120                 125             


Tyr Ile Ala Gly Arg Leu Gln Lys Pro Val Lys Ile Ile Ser Val Asn 
    130                 135                 140                 


Glu Asp Val Thr Leu Arg Ser Ala Leu Asp Arg Asn Leu Lys Ser Ala 
145                 150                 155                 160 


Val Thr Ala Ala Phe Leu Met Leu Pro Glu Ser Phe Ser Glu Glu Asp 
                165                 170                 175     


Leu Phe Ile Glu Ile Ala Gly Leu Ser Tyr Ser Gly Asp Phe Arg Met 
            180                 185                 190         


Val Val Gly Glu Asp Lys Thr Lys Val Leu Asn Ile Val Lys Pro Asn 
        195                 200                 205             


Ile Ala His Phe Arg Glu Leu Tyr Gly Ser Ile Leu Gln Glu Asn Pro 
    210                 215                 220                 


Gln Val Val Tyr Lys Ser Gln Gln Gly Trp Leu Glu Ile Asp Lys Ser 
225                 230                 235                 240 


Pro Glu Gly Gln Phe Thr Gln Leu Met Thr Leu Pro Lys Thr Leu Gln 
                245                 250                 255     


Gln Gln Ile Asn His Ile Met Asp Pro Pro Gly Lys Asn Arg Asp Val 
            260                 265                 270         


Glu Glu Thr Leu Phe Gln Val Ala His Asp Pro Asp Cys Gly Asp Val 
        275                 280                 285             


Val Arg Leu Gly Leu Lys Lys Ser Val Ile Tyr Ser Ser Leu Lys Leu 
    290                 295                 300                 


His Lys Met Trp Lys Gly Trp Leu Arg Lys Thr Ser 
305                 310                 315     


<210>  751
<211>  3899
<212>  DNA
<213>  Homosapiens

<400>  751
tccgccgctg ctgtctgcgg ggtctggcgc cggggtctga gtctctgctg gctaagccgc     60

cgcctcagcc gcctcagtcg cctcaatctc gccttccgcc ctcgctctcc ctccgcgcca    120

ccagaccccg tagccccgcg cgcccccagc cctttaagcc agatgatgaa cttcctgcgg    180

cgccggctgt cggacagcag cttcatcgcc aacctgccca acggctacat gaccgacctg    240

cagcggcccg agccccagca gccgccgccg ccgccgcccc ccggtccggg cgccgcctcg    300

gcctcggcgg cgcccccgac cgcctcgccg ggcccggagc ggaggccgcc gcccgcctcg    360

gcgcccgcgc cgcagcccgc gccgacgccg tcggtgggca gcagcttctt cagctcgctg    420

tcccaagccg tgaagcagac ggccgcctcg gctggcctgg tggacgcgcc cgctcccgcg    480

cccgcagccg ccaggaaggc caaggtgctg ctggtggtcg acgagccgca cgccgactgg    540

gccaagtgct ttcggggcaa aaaagtcctt ggagattatg atatcaaggt ggaacaggca    600

gaattttcag agctcaacct ggtggcccat gcagatggca cctatgctgt ggatatgcag    660

gttctccgga atggcacaaa ggttgtccgg tccttccggc cagacttcgt gctcatccgg    720

cagcatgcat ttggcatggc ggagaatgag gacttccgcc acctgatcat tggtatgcag    780

tatgcaggcc tccccagcat caactcactg gaatccatat acaacttctg tgacaagcca    840

tgggtgtttg cccagctggt cgctatctat aagacactgg gaggagaaaa gttccctctc    900

attgaacaga catactaccc caaccacaaa gagatgctga cactgcccac gttccctgtg    960

gtggtgaaga ttggccacgc tcactcaggc atgggcaagg tcaaagtgga aaaccactac   1020

gacttccagg acattgccag cgtggtggct ctcacccaga cctatgccac tgcagagcct   1080

ttcattgact ccaagtatga catccgggtc cagaagattg gcaacaacta caaggcttac   1140

atgaggacat cgatctcagg gaactggaag acgaacactg gctctgcgat gctggagcag   1200

attgccatgt cagacaggta caaactgtgg gtggacacct gctctgagat gtttggcggc   1260

ctggacatct gtgctgtcaa agctgtacat ggcaaagatg ggaaagacta catttttgag   1320

gtcatggact gtagcatgcc actgattggg gaacatcagg tggaggacag gcaactcatc   1380

accgaactag tcatcagcaa gatgaaccag ctgctgtcca ggactcctgc cctgtctcct   1440

cagagacccc taacaaccca gcagccacag agcggaacac ttaaggatcc ggactcaagc   1500

aagaccccac ctcagcggcc accccctcaa ggttgtttac agtatattct cgactgtaat   1560

ggcattgcag tagggccaaa acaagtccaa gcttcttaaa atgattggtg gttaattttt   1620

caaagcagaa attttaagcc aaaaacaaac gaaaggaaag cggggagggg aaaacagacc   1680

ctcccactgg tgccgttgct gcgttctttc aatgctgact ggactgtgtt tttcctatgc   1740

agtgtcagct cctctgtctg gttgtttacc tgttcctgtt cgtgcttgta atgctcactt   1800

atgttttctc tgtataactt gtgattccag ggctgtttgt caacagtata caaaagaatt   1860

gtgcctctcc caagtccagt gtgactttat cttctgggtg gtttgatagt gtttttaaaa   1920

gtaatatata atgtggggtg aaatgggagt aggggggtgg acaggggaga aacgaaaacc   1980

acaaaaagaa aacccaactc ctctcctccc cccaagctca gttaaatccc ccacctccaa   2040

ctttccctcc accagtgtgc ttgggatctt caatgaactg tgcttttcgc tttctttctg   2100

catgactatt gtaactagat agaacattaa gagattttca agatcaaact tccatagctt   2160

catccactga atttgaaggc atccaccttt ttctccattt gctaaaattt ggtgcagttt   2220

gagtttatgt gaataggctg gctgtgcctg tagagctctt gtgtttttag tgatgacatg   2280

aaatacaaag aacaagctat ttccaggaat gtgttctgta ttttacatcc cagtgtaccc   2340

tttattttat tattaactaa ttaactatga gatttttaaa aaatggggcc gctgatgtgc   2400

aatatcaaag tgaacttgtg agtattttgt gtgtgttgat ctcagttgtt tcttcattgt   2460

tgctgtttct ggatccagcc atgtgtgcgc ttgtgtggac ctgaggctgc tttctgttcc   2520

caaagcttga cctgtgtaca gagataattc cttggcaatg ttggacatag aatgcaggga   2580

gctactgaag gtctgtcagg gatttgtcca ttctgctctt ggcctctcct gaggcctcat   2640

aatgggagac caaatcaaaa atgtcccatg tcacttgagt gggtacactg cctacagaac   2700

cttgaggttg actcctgctt cagttctcag ctgtttacca cagccctcca gggtccaaag   2760

attgaggagc tttctctttc ctgggaggaa ctgtctcaga tttagcttgt gtgtgttttg   2820

gacagaggct ccacagcggt ggctcttgag gaatcctcac cagtttgttc tcttccctct   2880

gacaagcagc acctgagcag atgctgaggc agttcattaa accaggcctc agcttcagtg   2940

cctcatcttg ccatctcccg gccaggctgg gaacgggcac caagcagccg cctctaacaa   3000

acaccatggt ccgtggaagt tcatgccagc agcttgcctt tgagaagaaa tgctgctggc   3060

tctattttta cattcccttc cacctctata ctgtcatgtc accgttctga actcccagat   3120

ctgagaagga actagtgttg gtggtatgta acaagagtta cgtatccagg ggcttgtgcc   3180

ttggtttctc ctttgattgc tggtaaattc tgaggccaca gagaaatgca ttgagtgtga   3240

atgttgtcat ctgtaatccc tccctcagct gataatggta gttgatctgt tgtaaatata   3300

tacatatatg catatttgca cttccagatg ggttgcataa gaatcaggtc cttaaatacc   3360

tcccaatctg atgaaacgat agaataaagt aacatttccc agaatggagg aatacattat   3420

tttatcgtat atttttgtcc aagcgataag ctgacggtgg tattgcttct ctgcatgtta   3480

tcagtgtgta catctggtgc ttttcatgtg tcatttgtga gccacaaatg caaagttgcc   3540

atttgaattc agtcaggcta cagggtggtg tcagtcaagg tctttcaggt gggggagaaa   3600

ttggttaggg ctcccactgc caaatgcaag cagatagcat aacctgactg ttatgtgccc   3660

tcaggcagca tgcttaggga caactctgtg gcctggggga catctgtgtc acagtatagg   3720

attgccattc aggtgttttg tacctatttc tttcctgacg ttgtcccctt tttttgtact   3780

gatccaactg ggagaacctc agccaatgct ggaagtatga ttgaagtacc tctcttttgt   3840

gactcttgta cagcttaatg tgcaataaag gaaaagttat atctgaaaaa aaaaaaaaa    3899


<210>  752
<211>  478
<212>  PRT
<213>  Homosapiens

<400>  752

Met Met Asn Phe Leu Arg Arg Arg Leu Ser Asp Ser Ser Phe Ile Ala 
1               5                   10                  15      


Asn Leu Pro Asn Gly Tyr Met Thr Asp Leu Gln Arg Pro Glu Pro Gln 
            20                  25                  30          


Gln Pro Pro Pro Pro Pro Pro Pro Gly Pro Gly Ala Ala Ser Ala Ser 
        35                  40                  45              


Ala Ala Pro Pro Thr Ala Ser Pro Gly Pro Glu Arg Arg Pro Pro Pro 
    50                  55                  60                  


Ala Ser Ala Pro Ala Pro Gln Pro Ala Pro Thr Pro Ser Val Gly Ser 
65                  70                  75                  80  


Ser Phe Phe Ser Ser Leu Ser Gln Ala Val Lys Gln Thr Ala Ala Ser 
                85                  90                  95      


Ala Gly Leu Val Asp Ala Pro Ala Pro Ala Pro Ala Ala Ala Arg Lys 
            100                 105                 110         


Ala Lys Val Leu Leu Val Val Asp Glu Pro His Ala Asp Trp Ala Lys 
        115                 120                 125             


Cys Phe Arg Gly Lys Lys Val Leu Gly Asp Tyr Asp Ile Lys Val Glu 
    130                 135                 140                 


Gln Ala Glu Phe Ser Glu Leu Asn Leu Val Ala His Ala Asp Gly Thr 
145                 150                 155                 160 


Tyr Ala Val Asp Met Gln Val Leu Arg Asn Gly Thr Lys Val Val Arg 
                165                 170                 175     


Ser Phe Arg Pro Asp Phe Val Leu Ile Arg Gln His Ala Phe Gly Met 
            180                 185                 190         


Ala Glu Asn Glu Asp Phe Arg His Leu Ile Ile Gly Met Gln Tyr Ala 
        195                 200                 205             


Gly Leu Pro Ser Ile Asn Ser Leu Glu Ser Ile Tyr Asn Phe Cys Asp 
    210                 215                 220                 


Lys Pro Trp Val Phe Ala Gln Leu Val Ala Ile Tyr Lys Thr Leu Gly 
225                 230                 235                 240 


Gly Glu Lys Phe Pro Leu Ile Glu Gln Thr Tyr Tyr Pro Asn His Lys 
                245                 250                 255     


Glu Met Leu Thr Leu Pro Thr Phe Pro Val Val Val Lys Ile Gly His 
            260                 265                 270         


Ala His Ser Gly Met Gly Lys Val Lys Val Glu Asn His Tyr Asp Phe 
        275                 280                 285             


Gln Asp Ile Ala Ser Val Val Ala Leu Thr Gln Thr Tyr Ala Thr Ala 
    290                 295                 300                 


Glu Pro Phe Ile Asp Ser Lys Tyr Asp Ile Arg Val Gln Lys Ile Gly 
305                 310                 315                 320 


Asn Asn Tyr Lys Ala Tyr Met Arg Thr Ser Ile Ser Gly Asn Trp Lys 
                325                 330                 335     


Thr Asn Thr Gly Ser Ala Met Leu Glu Gln Ile Ala Met Ser Asp Arg 
            340                 345                 350         


Tyr Lys Leu Trp Val Asp Thr Cys Ser Glu Met Phe Gly Gly Leu Asp 
        355                 360                 365             


Ile Cys Ala Val Lys Ala Val His Gly Lys Asp Gly Lys Asp Tyr Ile 
    370                 375                 380                 


Phe Glu Val Met Asp Cys Ser Met Pro Leu Ile Gly Glu His Gln Val 
385                 390                 395                 400 


Glu Asp Arg Gln Leu Ile Thr Glu Leu Val Ile Ser Lys Met Asn Gln 
                405                 410                 415     


Leu Leu Ser Arg Thr Pro Ala Leu Ser Pro Gln Arg Pro Leu Thr Thr 
            420                 425                 430         


Gln Gln Pro Gln Ser Gly Thr Leu Lys Asp Pro Asp Ser Ser Lys Thr 
        435                 440                 445             


Pro Pro Gln Arg Pro Pro Pro Gln Gly Cys Leu Gln Tyr Ile Leu Asp 
    450                 455                 460                 


Cys Asn Gly Ile Ala Val Gly Pro Lys Gln Val Gln Ala Ser 
465                 470                 475             


<210>  753
<211>  2694
<212>  DNA
<213>  Homosapiens

<400>  753
tccgccgctg ctgtctgcgg ggtctggcgc cggggtctga gtctctgctg gctaagccgc     60

cgcctcagcc gcctcagtcg cctcaatctc gccttccgcc ctcgctctcc ctccgcgcca    120

ccagaccccg tagccccgcg cgcccccagc cctttaagcc agatgatgaa cttcctgcgg    180

cgccggctgt cggacagcag cttcatcgcc aacctgccca acggctacat gaccgacctg    240

cagcggcccg agccccagca gccgccgccg ccgccgcccc ccggtccggg cgccgcctcg    300

gcctcggcgg cgcccccgac cgcctcgccg ggcccggagc ggaggccgcc gcccgcctcg    360

gcgcccgcgc cgcagcccgc gccgacgccg tcggtgggca gcagcttctt cagctcgctg    420

tcccaagccg tgaagcagac ggccgcctcg gctggcctgg tggacgcgcc cgctcccgcg    480

cccgcagccg ccaggaaggc caaggtgctg ctggtggtcg acgagccgca cgccgactgg    540

gccaagtgct ttcggggcaa aaaagtcctt ggagattatg atatcaaggt ggaacaggca    600

gaattttcag agctcaacct ggtggcccat gcagatggca cctatgctgt ggatatgcag    660

gttctccgga atggcacaaa ggttgtccgg tccttccggc cagacttcgt gctcatccgg    720

cagcatgcat ttggcatggc ggagaatgag gacttccgcc acctgatcat tggtatgcag    780

tatgcaggcc tccccagcat caactcactg gaatccatat acaacttctg tgacaagcca    840

tgggtgtttg cccagctggt cgctatctat aagacactgg gaggagaaaa gttccctctc    900

attgaacaga catactaccc caaccacaaa gagatgctga cactgcccac gttccctgtg    960

gtggtgaaga ttggccacgc tcactcaggc atgggcaagg tcaaagtgga aaaccactac   1020

gacttccagg acattgccag cgtggtggct ctcacccaga cctatgccac tgcagagcct   1080

ttcattgact ccaagtatga catccgggtc cagaagattg gcaacaacta caaggcttac   1140

atgaggacat cgatctcagg gaactggaag acgaacactg gctctgcgat gctggagcag   1200

attgccatgt cagacaggta caaactgtgg gtggacacct gctctgagat gtttggcggc   1260

ctggacatct gtgctgtcaa agctgtacat ggcaaagatg ggaaagacta catttttgag   1320

gtcatggact gtagcatgcc actgattggg gaacatcagg tggaggacag gcaactcatc   1380

accgaactag tcatcagcaa gatgaaccag ctgctgtcca ggactcctgc cctgtctcct   1440

cagagacccc taacaaccca gcagccacag agcggaacac ttaaggatcc ggactcaagc   1500

aagaccccac ctcagcggcc accccctcaa gggggccctg ggcaacccca aggaatgcag   1560

cccccaggca aggtgctgcc tccacgccgg ctcccccctg gaccatcact gccaccttcc   1620

tcctcttcct cctcttcttc ctcctcctcg gctcctcagc ggccgggcgg ccccaccacc   1680

cacggagatg caccctccag cagcagctcc ctggcagagg cccagccacc cctggctgct   1740

ccaccacaga agccccagcc tcacccacag ctcaacaagt cgcagtccct gacaaatgcc   1800

ttcagcttct ctgagtcctc cttcttccgg tcttcagcca atgaggatga agccaaagca   1860

gagaccatcc ggagcttgag gaagtccttt gccagcctct tttcagatta gctcttcaga   1920

cacacggggc acccagccca accgggaaag gcatctaaga cattcaccaa caacagtcag   1980

ccagcttggt ggttatgtcc catgaccttg acgtgtgtgg tcccttcctc tgctctgttg   2040

tactaagtga tgttgtgcag cccagaaagg accatttgac agtctcaggg caggtgccta   2100

cccagcaagg ggtacctggc atcagagagg aaagagctgc ttccctgtag tcatgagagc   2160

ttccttctga agtcatcgtt cgctgtgagt ttagtggcct tattgtgaca gtgccatcat   2220

gtcttattct tccctgtgaa accaggatta atcgtggact cctggcagct taacctagct   2280

cagttgcagt gctaagcatg ccccgccccc attcagtgat acctgtttgg gaagtatata   2340

cttccccaaa agtactcttg gccctaagtt ttaggaactt tccccgacct ggatcccttg   2400

tcatacctgt gttactgttt aaagcacacc cacccaactt acaagatctt aggctgctgt   2460

ggtggtgaag caccttgagt ctgctgatat tcgggagaac aaggatctgc agtttcccct   2520

tttctcccct ctgaagagtg gttcttatgt gcaatctgca gtaaccttga actccagagc   2580

tgcactatag aggagaatgc atgccactat gacagcagta tgccaagctt tgtgttcatc   2640

tcctaataaa cgttaagacc tttggtgtaa taaaaaaaaa aaaaaaaaaa aaaa         2694


<210>  754
<211>  582
<212>  PRT
<213>  Homosapiens

<400>  754

Met Met Asn Phe Leu Arg Arg Arg Leu Ser Asp Ser Ser Phe Ile Ala 
1               5                   10                  15      


Asn Leu Pro Asn Gly Tyr Met Thr Asp Leu Gln Arg Pro Glu Pro Gln 
            20                  25                  30          


Gln Pro Pro Pro Pro Pro Pro Pro Gly Pro Gly Ala Ala Ser Ala Ser 
        35                  40                  45              


Ala Ala Pro Pro Thr Ala Ser Pro Gly Pro Glu Arg Arg Pro Pro Pro 
    50                  55                  60                  


Ala Ser Ala Pro Ala Pro Gln Pro Ala Pro Thr Pro Ser Val Gly Ser 
65                  70                  75                  80  


Ser Phe Phe Ser Ser Leu Ser Gln Ala Val Lys Gln Thr Ala Ala Ser 
                85                  90                  95      


Ala Gly Leu Val Asp Ala Pro Ala Pro Ala Pro Ala Ala Ala Arg Lys 
            100                 105                 110         


Ala Lys Val Leu Leu Val Val Asp Glu Pro His Ala Asp Trp Ala Lys 
        115                 120                 125             


Cys Phe Arg Gly Lys Lys Val Leu Gly Asp Tyr Asp Ile Lys Val Glu 
    130                 135                 140                 


Gln Ala Glu Phe Ser Glu Leu Asn Leu Val Ala His Ala Asp Gly Thr 
145                 150                 155                 160 


Tyr Ala Val Asp Met Gln Val Leu Arg Asn Gly Thr Lys Val Val Arg 
                165                 170                 175     


Ser Phe Arg Pro Asp Phe Val Leu Ile Arg Gln His Ala Phe Gly Met 
            180                 185                 190         


Ala Glu Asn Glu Asp Phe Arg His Leu Ile Ile Gly Met Gln Tyr Ala 
        195                 200                 205             


Gly Leu Pro Ser Ile Asn Ser Leu Glu Ser Ile Tyr Asn Phe Cys Asp 
    210                 215                 220                 


Lys Pro Trp Val Phe Ala Gln Leu Val Ala Ile Tyr Lys Thr Leu Gly 
225                 230                 235                 240 


Gly Glu Lys Phe Pro Leu Ile Glu Gln Thr Tyr Tyr Pro Asn His Lys 
                245                 250                 255     


Glu Met Leu Thr Leu Pro Thr Phe Pro Val Val Val Lys Ile Gly His 
            260                 265                 270         


Ala His Ser Gly Met Gly Lys Val Lys Val Glu Asn His Tyr Asp Phe 
        275                 280                 285             


Gln Asp Ile Ala Ser Val Val Ala Leu Thr Gln Thr Tyr Ala Thr Ala 
    290                 295                 300                 


Glu Pro Phe Ile Asp Ser Lys Tyr Asp Ile Arg Val Gln Lys Ile Gly 
305                 310                 315                 320 


Asn Asn Tyr Lys Ala Tyr Met Arg Thr Ser Ile Ser Gly Asn Trp Lys 
                325                 330                 335     


Thr Asn Thr Gly Ser Ala Met Leu Glu Gln Ile Ala Met Ser Asp Arg 
            340                 345                 350         


Tyr Lys Leu Trp Val Asp Thr Cys Ser Glu Met Phe Gly Gly Leu Asp 
        355                 360                 365             


Ile Cys Ala Val Lys Ala Val His Gly Lys Asp Gly Lys Asp Tyr Ile 
    370                 375                 380                 


Phe Glu Val Met Asp Cys Ser Met Pro Leu Ile Gly Glu His Gln Val 
385                 390                 395                 400 


Glu Asp Arg Gln Leu Ile Thr Glu Leu Val Ile Ser Lys Met Asn Gln 
                405                 410                 415     


Leu Leu Ser Arg Thr Pro Ala Leu Ser Pro Gln Arg Pro Leu Thr Thr 
            420                 425                 430         


Gln Gln Pro Gln Ser Gly Thr Leu Lys Asp Pro Asp Ser Ser Lys Thr 
        435                 440                 445             


Pro Pro Gln Arg Pro Pro Pro Gln Gly Gly Pro Gly Gln Pro Gln Gly 
    450                 455                 460                 


Met Gln Pro Pro Gly Lys Val Leu Pro Pro Arg Arg Leu Pro Pro Gly 
465                 470                 475                 480 


Pro Ser Leu Pro Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                485                 490                 495     


Ala Pro Gln Arg Pro Gly Gly Pro Thr Thr His Gly Asp Ala Pro Ser 
            500                 505                 510         


Ser Ser Ser Ser Leu Ala Glu Ala Gln Pro Pro Leu Ala Ala Pro Pro 
        515                 520                 525             


Gln Lys Pro Gln Pro His Pro Gln Leu Asn Lys Ser Gln Ser Leu Thr 
    530                 535                 540                 


Asn Ala Phe Ser Phe Ser Glu Ser Ser Phe Phe Arg Ser Ser Ala Asn 
545                 550                 555                 560 


Glu Asp Glu Ala Lys Ala Glu Thr Ile Arg Ser Leu Arg Lys Ser Phe 
                565                 570                 575     


Ala Ser Leu Phe Ser Asp 
            580         


<210>  755
<211>  2082
<212>  DNA
<213>  Homosapiens

<400>  755
agattgctgc ctatgcaaag caggtaagaa gccgaactct gaggcctctc gccattgtct     60

ccgagtcggc cagctggagc gttttcgggg ctgtaaaggg agaatggcgc atgcgcatat    120

tcagggcgga aggcgcgcta agagcagatt tgtggtctgc attatgtctg gagccagaag    180

taagcttgct cttttcctct gcggctgtta cgtggttgcc ctgggagccc acaccgggga    240

ggagagcgtg gctgaccatc acgaggctga atattatgtg gctgccgtgt atgagcatcc    300

atccatcctg agtctgaacc ctctggctct catcagccgc caagaggcct tggagctcat    360

gaaccagaac cttgacatct atgaacagca agtgatgact gcagcccaaa aggatgtaca    420

gattatagtg tttccagaag atggcattca tggattcaac tttacaagaa catccattta    480

tccatttttg gacttcatgc cgtctcccca ggtggtcagg tggaacccat gcctggagcc    540

tcaccgcttc aatgacacag aggtgctcca gcgcctgagt tgtatggcca tcaggggaga    600

tatgttcttg gtggccaatc ttgggacaaa ggagccttgt catagcagtg acccaaggtg    660

cccaaaagat gggagatacc agttcaacac aaatgtcgtg ttcagcaata atggaaccct    720

tgttgaccgc taccgtaaac acaacctcta ctttgaggca gcattcgatg ttcctcttaa    780

agtggatctc atcacctttg ataccccctt tgctggcagg tttggcatct tcacatgctt    840

tgatatattg ttctttgacc ctgccatcag agtcctcaga gactacaagg tgaagcatgt    900

tgtgtaccca actgcctgga tgaaccagct cccactcttg gcagcaattg agattcagaa    960

agcttttgct gttgcctttg gcatcaacgt tctggcagct aatgtccacc acccagttct   1020

ggggatgaca ggaagtggca tacacacccc tctggagtcc ttttggtacc atgacatgga   1080

aaatcccaaa agtcacctta taattgccca ggtggccaaa aatccagtgg gtctcattgg   1140

tgcagagaat gcaacaggtg aaacggaccc atcccatagt aagtttttaa aaattttgtc   1200

aggcgatccg tactgtgaga aggatgctca ggaagtccac tgtgatgagg ccaccaagtg   1260

gaacgtgaat gctcctccca catttcactc tgagatgatg tatgacaatt tcaccctggt   1320

ccctgtctgg ggaaaggaag gctatctcca cgtctgttcc aatggcctct gctgttattt   1380

actttacgag aggcccacct tatccaaaga gctgtatgcc ctgggggtct ttgatgggct   1440

tcacacagta catggcactt actacatcca agtgtgtgcc ctggtcaggt gtgggggtct   1500

tggcttcgac acctgtggac aggaaatcac agaggccacg gggatatttg agtttcacct   1560

gtggggcaac ttcagtactt cctatatctt tcctttgttt ctgacctcag ggatgaccct   1620

agaagtccct gaccagcttg gctgggagaa tgaccactat ttcctgagga aaagtaggct   1680

gtcctctggg ctggtgacgg cggctctcta tgggcgcttg tatgagaggg actaggaaaa   1740

gtgtgtggtc tgtggggcgg actctggcca tcatgttgac agccttgcac ttccacaggc   1800

tacaagccct gggaccatct ttctgcctta agggcaggag cccacttctg tggcaccaga   1860

ttccaccctg ggaactgtgg aaaaagtagg agaggcagat tccctcagtg tcttcctctt   1920

aaacctcaat catcgagaca ttagggggta ttttctgttc acatttatct ttttcaagcc   1980

acatcttcct ctaacaaatc tctcagtatg cgattggtct caagctaaaa caaaaataaa   2040

tgtcagttta tattttacac atccaaaaaa aaaaaaaaaa aa                      2082


<210>  756
<211>  543
<212>  PRT
<213>  Homosapiens

<400>  756

Met Ala His Ala His Ile Gln Gly Gly Arg Arg Ala Lys Ser Arg Phe 
1               5                   10                  15      


Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu 
            20                  25                  30          


Cys Gly Cys Tyr Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser 
        35                  40                  45              


Val Ala Asp His His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu 
    50                  55                  60                  


His Pro Ser Ile Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln 
65                  70                  75                  80  


Glu Ala Leu Glu Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln 
                85                  90                  95      


Val Met Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu 
            100                 105                 110         


Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe 
        115                 120                 125             


Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu 
    130                 135                 140                 


Glu Pro His Arg Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys 
145                 150                 155                 160 


Met Ala Ile Arg Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys 
                165                 170                 175     


Glu Pro Cys His Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr 
            180                 185                 190         


Gln Phe Asn Thr Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp 
        195                 200                 205             


Arg Tyr Arg Lys His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro 
    210                 215                 220                 


Leu Lys Val Asp Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe 
225                 230                 235                 240 


Gly Ile Phe Thr Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg 
                245                 250                 255     


Val Leu Arg Asp Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp 
            260                 265                 270         


Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe 
        275                 280                 285             


Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro 
    290                 295                 300                 


Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe 
305                 310                 315                 320 


Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln 
                325                 330                 335     


Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly 
            340                 345                 350         


Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp 
        355                 360                 365             


Pro Tyr Cys Glu Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr 
    370                 375                 380                 


Lys Trp Asn Val Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr 
385                 390                 395                 400 


Asp Asn Phe Thr Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His 
                405                 410                 415     


Val Cys Ser Asn Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr 
            420                 425                 430         


Leu Ser Lys Glu Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr 
        435                 440                 445             


Val His Gly Thr Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly 
    450                 455                 460                 


Gly Leu Gly Phe Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly 
465                 470                 475                 480 


Ile Phe Glu Phe His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe 
                485                 490                 495     


Pro Leu Phe Leu Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu 
            500                 505                 510         


Gly Trp Glu Asn Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser 
        515                 520                 525             


Gly Leu Val Thr Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 
    530                 535                 540             


<210>  757
<211>  6339
<212>  DNA
<213>  Homosapiens

<400>  757
ggtcttctca gcgcagtcgg gcgcggaccc gctggtcccg ggcagcggcc aaggctactg     60

gggcgggagc agtgggccgg tcggcggcgg cagcggcagc ggcggaggag gaggaggctg    120

gagtgggcgc ggaggcgacc gccatggcgt tcctcaaact ccgtgaccag ccatcactgg    180

tgcaagctat atttaacgga gatcctgatg aagttcgagc actaatattt aagaaagaag    240

atgttaactt tcaggacaat gaaaagcgaa ccccattgca cgccgcagct taccttggag    300

atgcagaaat cattgaactt cttattttat ctggagctag agttaatgcc aaagacagca    360

aatggttgac acctttacac agagcagttg catcttgtag tgaggaagca gttcaggtac    420

ttttgaagca ttctgcagat gttaatgctc gagacaaaaa ttggcaaacc cctttacata    480

tagctgctgc taataaagct gtaaagtgtg ctgaagcttt ggtacctctt ctgagtaatg    540

taaacgtatc tgatcgagca gggaggactg cattacatca tgcagctttc agtggacatg    600

gtgagatggt caaactactc ttgtctagag gtgccaatat taatgctttt gacaagaaag    660

ataggcgtgc tatccattgg gcagcatata tgggtcacat tgaagtagtg aaattgcttg    720

tgtcgcatgg agctgaagtg acatgcaagg ataaaaagtc ttatacacct cttcatgcag    780

cagcctctag tggaatgatc agcgtagtca agtaccttct agatcttgga gttgatatga    840

atgaaccaaa tgcctatgga aatacacctc ttcatgtagc ctgctataat ggacaagatg    900

ttgtagtgaa tgaacttata gactgtggtg ctattgtgaa tcaaaagaat gaaaaaggat    960

ttactccttt gcactttgct gctgcatcaa cacatggagc attgtgttta gagcttctag   1020

ttggcaatgg ggccgatgtc aatatgaaga gtaaagatgg gaaaacccca ctacacatga   1080

ctgctctcca cggtagattc tcccgatcac aaaccattat ccagagtgga gctgtaatcg   1140

actgtgagga taagaatgga aatacccctt tgcacatagc agcacggtat ggccatgagc   1200

tgctgatcaa cactcttatt acaagtggtg ctgacactgc aaagcgtggc atacatggaa   1260

tgttccccct ccatttggca gccttaagcg gcttttcaga ttgctgcaga aaacttcttt   1320

cttcaggatt tgatatagat accccagatg attttggcag gacttgtcta catgcagctg   1380

cagctggagg gaatttggag tgcctaaacc ttctgctgaa tactggtgca gactttaata   1440

aaaaggacaa atttgggaga tctccactgc actacgctgc tgccaactgc aattaccagt   1500

gcctgtttgc tcttgtggga tcaggagcaa gtgtgaatga ccttgatgaa agaggctgca   1560

cacccctgca ctatgcagct acatcagaca cagatggcaa gtgcctggaa tacttattaa   1620

gaaacgatgc aaatccaggg atccgtgata agcaaggata caacgcagtt cattattcag   1680

ctgcttatgg tcaccgtcta tgtcttcagc tgattgcaag tgaaactcct ctagatgttt   1740

taatggaaac ctcaggaaca gacatgctga gtgattcaga taatagagca acaataagcc   1800

ctttacactt ggctgcctat catggtcacc atcaagcact ggaagtgttg gtacagtctt   1860

tgttagatct tgatgtcaga aatagtagtg gaagaacacc cctagatctt gcagctttta   1920

agggccatgt tgaatgtgtg gatgtactca ttaatcaggg agcctcaatc ttagtaaaag   1980

attacatttt gaagaggaca cctattcatg cagcagcaac aaatggtcat tcagaatgct   2040

tacggctatt aataggaaat gcagaaccac agaatgcagt ggatattcaa gatggaaatg   2100

gacagacgcc tctgatgcta tctgttctca acgggcacac agactgtgtt tactcattgc   2160

tgaacaaagg agcaaatgta gatgccaaag ataagtgggg aaggacagcg ttgcatagag   2220

gggcagttac aggccatgaa gaatgtgtag atgcattact tcaacatggt gctaagtgct   2280

tacttcggga tagcaggggc cggacgccta tacacctgtc tgctgcctgt ggacacattg   2340

gtgttcttgg agcccttttg cagtcagcag catctatgga tgcaaatcca gccacagcag   2400

acaatcatgg atatacggca cttcactggg cttgctacaa tggtcacgag acatgtgtag   2460

aactgctttt agaacaggaa gttttccaga aaacggaagg aaatgctttt agtccattgc   2520

attgtgccgt gataaatgac aacgaaggtg ctgctgagat gttaattgat acattaggtg   2580

ccagcattgt gaacgccaca gattcaaaag gaagaactcc tctccatgca gccgccttca   2640

cagaccatgt agagtgttta cagctgctgc tcagccataa tgctcaagtc aattctgtgg   2700

actctacagg gaaaacacct cttatgatgg ctgcagaaaa tggacaaaca aatacagttg   2760

agatgctggt tagcagtgct agtgcagaac tgactttaca agataacagt aaaaatactg   2820

ccctccattt ggcttgtagc aagggtcatg aaactagtgc cttgttaata ctggaaaaga   2880

taacagatag aaacctcatc aatgcaacca acgcagcctt gcaaacacct ctgcatgttg   2940

ctgcccgaaa tgggctaaca atggtggttc aggaactttt gggaaaagga gcaagtgtgc   3000

ttgcagtaga tgaaaatggc tataccccag ctttggcctg tgctcccaat aaggatgtgg   3060

ctgattgcct ggctctcatt ttggccacca tgatgcctgt ctcatcaagt agtcctttat   3120

catccttaac attcaatgcc attaaccgtt ataccaacac ctcaaaaaca gtcagctttg   3180

aagctttgcc catcatgagg aatgaaccta gctcctattg cagtttcaat aacattggag   3240

gggaacagga gtacttatac actgacgtgg atgagctcaa cgactccgat tctgagacct   3300

actgagaggc tgaggaggag ggagttctca cagtaaagct tcaaactgtg ctttttcagg   3360

aaaaaggcac tttgatattc acgtagaaat tcaacctaag aggaaagatc ccacagtgag   3420

ccaatgttaa gagatctgat ggcattagga ggaagagttt taaaggcaag ttttacaaaa   3480

ggaacttcta gaatcttgaa atagacctga ctgaggaaaa cacattgatg tcagaattct   3540

ttgtggaatt gtttaatttg gttttgcagt gccaggaaca attggggaca ctgtgcactc   3600

taacctgctt acacaagcaa cactattgta acagaagaaa taaagacact agatttaaat   3660

tttatcaata aaattacaac taaatttaaa ggcaataaaa gtttggtaca gtaggcatta   3720

tgtgcacagc aaattgcaaa aggaccaaat aactgaaagg tttttttaat aaaatgccat   3780

tttgtggaaa ctggagtaga ttaaatgaaa cattacctaa accaaactgc aatatttctg   3840

gaaatgaagc tgagatttgg ttttaaatgt tgagtttttt tgggttttgt ttttttttta   3900

agaaaacatc tgaaagcctt ccaatgctgt attaaaccat gagagaaagc agatgtattt   3960

ttacattttt ttcttttaca gaactatttc aaatttccaa tttttatact attagaatta   4020

aaaaccagct gactgggtgc aatacgggtg aaaatacttg tgacatagac attgagatgg   4080

attggggtca ggctgttgcc ctgttttgaa tggtttgggt ttaaaatagt actatttttg   4140

tttgaaaatg taaagaattt cctagaaaaa aattcatgaa atcaaaaagt agactatttc   4200

accctattgc agctaagtgg tcctggggca tggagtcttc aacctctcta tgaatggcac   4260

accttagtca cttatgttac ttttgtgtcc ccaccatggg ttgggggatt ttttgtttat   4320

tctgatctat gagttttgaa aaagtgaata atcaaaagga aaataattcc ttgttgttca   4380

taaattaagc atcactaaag tctcttgaaa ggcatttctg tattgggcaa gatttaaaat   4440

actaaagcct taggtcctat tcatatttaa agtagcatgt ttgtaacctg ttactatttg   4500

gagagagaag cagttgcctg ccaaattgaa gactaccttt caaatagcaa aagagagaga   4560

gaaggctgat atttcggctt ttaaataaag atttgtgtgg ttctgctttt actgtaactg   4620

tcactttccc agtgaaaatg atttcatata cattgagggt cttacaggta tgggtaaagt   4680

tctataaatt gcaacaaaat gatacccaat ttcattttat cctttttgta ttgtgaaact   4740

ggaaacttta tgacattgta aattatcagc tggtttttct gaatataaag tgtgaaaaca   4800

cagaacagta ttttgatcta tttgataatt ttgtgggttt tttgaagaat taatgagcat   4860

gtacatagaa atagtgactg cttgaatact gtatttactt gcactctttc agtacatcaa   4920

gattcctgta tattttagag tataataaaa cacagatgtg agttgtattt aatgaataat   4980

gtatttgtat ctgtgcatat tatctacaaa tctataaagt ttctagggca ttgactacta   5040

gattttaagc attttttcta aaatatttac agaaattata aatctaatcc cccatctttt   5100

ctttataata taaagaagtc ataatgaacc cttcctaatt attagtagta ggaaggtgaa   5160

tatgcatttt aatgacagtg gactacattt tctattgtac cttttgaaaa aaaaaaaaat   5220

caagcagatt ctaaaagtat acatatgtgt gctttctctt tccttttagg aattctcttc   5280

tgaattccct gagggaattt tctagaatct cagaattgaa agagacctga ggttcatcca   5340

gtctctaacc tcttaacaaa tgcaggagtc ccttctacaa gggtgatctt tccaccttga   5400

acacttccaa gtgactctac ctcaccaagc agtccattca gttgttgagc agctctaact   5460

gttagaaagg tcttccttag atggagttga agcctccctc ccggtaactt ctgtctttgg   5520

gcctgggtct gtcctccaag agaaccctga gaatgttgga aggatgaatc tcgcacattc   5580

tgccatgtct tctcttttac aggctgtttg acttctctgc tgaagtgatt tccagaagga   5640

ctcatttgac acactattag atttaccaca tctaatgaaa tccaaggtgt agctataaag   5700

tgacaagctg tttttaattt atcacataca ccagaacttc tatcctgcat cacttatatg   5760

taaatgatgc tgttaccaaa aacattaagg tagttcttgc gaatgccacc ccactaagaa   5820

aactatttca ttacttttgt aatccatctg tgagagtctg ccccccagct taaccacttc   5880

ctttggtctg cacccaatga agggaaaccc caaagtactg tctcaaatgg tatttgaact   5940

acgccagtat tgttggaata agtacattaa ttacttgaat gaatgaacac agcaccgtag   6000

aaatttcctt tatggttaca ccttgtatgt ctaaagcatt caggccctgt tctgtagtgt   6060

ttcttatcct cacacagagt agaaaagcct gtttgcttta tttaacttat acataaaaga   6120

tgacatctga aatatctgat gtgtattata ataccagctt ctgctctaga actactttgg   6180

gtgaaatggt ggtaatagca aatgacctcc tttaacaaga cactcatctc aaacaatgcc   6240

atttagttca ggagatctct aagtgtagct gtaaattttg gggttaattt ggcttatatt   6300

ggacctttta aaagaaataa agttttttaa tgcaataaa                          6339


<210>  758
<211>  1053
<212>  PRT
<213>  Homosapiens

<400>  758

Met Ala Phe Leu Lys Leu Arg Asp Gln Pro Ser Leu Val Gln Ala Ile 
1               5                   10                  15      


Phe Asn Gly Asp Pro Asp Glu Val Arg Ala Leu Ile Phe Lys Lys Glu 
            20                  25                  30          


Asp Val Asn Phe Gln Asp Asn Glu Lys Arg Thr Pro Leu His Ala Ala 
        35                  40                  45              


Ala Tyr Leu Gly Asp Ala Glu Ile Ile Glu Leu Leu Ile Leu Ser Gly 
    50                  55                  60                  


Ala Arg Val Asn Ala Lys Asp Ser Lys Trp Leu Thr Pro Leu His Arg 
65                  70                  75                  80  


Ala Val Ala Ser Cys Ser Glu Glu Ala Val Gln Val Leu Leu Lys His 
                85                  90                  95      


Ser Ala Asp Val Asn Ala Arg Asp Lys Asn Trp Gln Thr Pro Leu His 
            100                 105                 110         


Ile Ala Ala Ala Asn Lys Ala Val Lys Cys Ala Glu Ala Leu Val Pro 
        115                 120                 125             


Leu Leu Ser Asn Val Asn Val Ser Asp Arg Ala Gly Arg Thr Ala Leu 
    130                 135                 140                 


His His Ala Ala Phe Ser Gly His Gly Glu Met Val Lys Leu Leu Leu 
145                 150                 155                 160 


Ser Arg Gly Ala Asn Ile Asn Ala Phe Asp Lys Lys Asp Arg Arg Ala 
                165                 170                 175     


Ile His Trp Ala Ala Tyr Met Gly His Ile Glu Val Val Lys Leu Leu 
            180                 185                 190         


Val Ser His Gly Ala Glu Val Thr Cys Lys Asp Lys Lys Ser Tyr Thr 
        195                 200                 205             


Pro Leu His Ala Ala Ala Ser Ser Gly Met Ile Ser Val Val Lys Tyr 
    210                 215                 220                 


Leu Leu Asp Leu Gly Val Asp Met Asn Glu Pro Asn Ala Tyr Gly Asn 
225                 230                 235                 240 


Thr Pro Leu His Val Ala Cys Tyr Asn Gly Gln Asp Val Val Val Asn 
                245                 250                 255     


Glu Leu Ile Asp Cys Gly Ala Ile Val Asn Gln Lys Asn Glu Lys Gly 
            260                 265                 270         


Phe Thr Pro Leu His Phe Ala Ala Ala Ser Thr His Gly Ala Leu Cys 
        275                 280                 285             


Leu Glu Leu Leu Val Gly Asn Gly Ala Asp Val Asn Met Lys Ser Lys 
    290                 295                 300                 


Asp Gly Lys Thr Pro Leu His Met Thr Ala Leu His Gly Arg Phe Ser 
305                 310                 315                 320 


Arg Ser Gln Thr Ile Ile Gln Ser Gly Ala Val Ile Asp Cys Glu Asp 
                325                 330                 335     


Lys Asn Gly Asn Thr Pro Leu His Ile Ala Ala Arg Tyr Gly His Glu 
            340                 345                 350         


Leu Leu Ile Asn Thr Leu Ile Thr Ser Gly Ala Asp Thr Ala Lys Arg 
        355                 360                 365             


Gly Ile His Gly Met Phe Pro Leu His Leu Ala Ala Leu Ser Gly Phe 
    370                 375                 380                 


Ser Asp Cys Cys Arg Lys Leu Leu Ser Ser Gly Phe Asp Ile Asp Thr 
385                 390                 395                 400 


Pro Asp Asp Phe Gly Arg Thr Cys Leu His Ala Ala Ala Ala Gly Gly 
                405                 410                 415     


Asn Leu Glu Cys Leu Asn Leu Leu Leu Asn Thr Gly Ala Asp Phe Asn 
            420                 425                 430         


Lys Lys Asp Lys Phe Gly Arg Ser Pro Leu His Tyr Ala Ala Ala Asn 
        435                 440                 445             


Cys Asn Tyr Gln Cys Leu Phe Ala Leu Val Gly Ser Gly Ala Ser Val 
    450                 455                 460                 


Asn Asp Leu Asp Glu Arg Gly Cys Thr Pro Leu His Tyr Ala Ala Thr 
465                 470                 475                 480 


Ser Asp Thr Asp Gly Lys Cys Leu Glu Tyr Leu Leu Arg Asn Asp Ala 
                485                 490                 495     


Asn Pro Gly Ile Arg Asp Lys Gln Gly Tyr Asn Ala Val His Tyr Ser 
            500                 505                 510         


Ala Ala Tyr Gly His Arg Leu Cys Leu Gln Leu Ile Ala Ser Glu Thr 
        515                 520                 525             


Pro Leu Asp Val Leu Met Glu Thr Ser Gly Thr Asp Met Leu Ser Asp 
    530                 535                 540                 


Ser Asp Asn Arg Ala Thr Ile Ser Pro Leu His Leu Ala Ala Tyr His 
545                 550                 555                 560 


Gly His His Gln Ala Leu Glu Val Leu Val Gln Ser Leu Leu Asp Leu 
                565                 570                 575     


Asp Val Arg Asn Ser Ser Gly Arg Thr Pro Leu Asp Leu Ala Ala Phe 
            580                 585                 590         


Lys Gly His Val Glu Cys Val Asp Val Leu Ile Asn Gln Gly Ala Ser 
        595                 600                 605             


Ile Leu Val Lys Asp Tyr Ile Leu Lys Arg Thr Pro Ile His Ala Ala 
    610                 615                 620                 


Ala Thr Asn Gly His Ser Glu Cys Leu Arg Leu Leu Ile Gly Asn Ala 
625                 630                 635                 640 


Glu Pro Gln Asn Ala Val Asp Ile Gln Asp Gly Asn Gly Gln Thr Pro 
                645                 650                 655     


Leu Met Leu Ser Val Leu Asn Gly His Thr Asp Cys Val Tyr Ser Leu 
            660                 665                 670         


Leu Asn Lys Gly Ala Asn Val Asp Ala Lys Asp Lys Trp Gly Arg Thr 
        675                 680                 685             


Ala Leu His Arg Gly Ala Val Thr Gly His Glu Glu Cys Val Asp Ala 
    690                 695                 700                 


Leu Leu Gln His Gly Ala Lys Cys Leu Leu Arg Asp Ser Arg Gly Arg 
705                 710                 715                 720 


Thr Pro Ile His Leu Ser Ala Ala Cys Gly His Ile Gly Val Leu Gly 
                725                 730                 735     


Ala Leu Leu Gln Ser Ala Ala Ser Met Asp Ala Asn Pro Ala Thr Ala 
            740                 745                 750         


Asp Asn His Gly Tyr Thr Ala Leu His Trp Ala Cys Tyr Asn Gly His 
        755                 760                 765             


Glu Thr Cys Val Glu Leu Leu Leu Glu Gln Glu Val Phe Gln Lys Thr 
    770                 775                 780                 


Glu Gly Asn Ala Phe Ser Pro Leu His Cys Ala Val Ile Asn Asp Asn 
785                 790                 795                 800 


Glu Gly Ala Ala Glu Met Leu Ile Asp Thr Leu Gly Ala Ser Ile Val 
                805                 810                 815     


Asn Ala Thr Asp Ser Lys Gly Arg Thr Pro Leu His Ala Ala Ala Phe 
            820                 825                 830         


Thr Asp His Val Glu Cys Leu Gln Leu Leu Leu Ser His Asn Ala Gln 
        835                 840                 845             


Val Asn Ser Val Asp Ser Thr Gly Lys Thr Pro Leu Met Met Ala Ala 
    850                 855                 860                 


Glu Asn Gly Gln Thr Asn Thr Val Glu Met Leu Val Ser Ser Ala Ser 
865                 870                 875                 880 


Ala Glu Leu Thr Leu Gln Asp Asn Ser Lys Asn Thr Ala Leu His Leu 
                885                 890                 895     


Ala Cys Ser Lys Gly His Glu Thr Ser Ala Leu Leu Ile Leu Glu Lys 
            900                 905                 910         


Ile Thr Asp Arg Asn Leu Ile Asn Ala Thr Asn Ala Ala Leu Gln Thr 
        915                 920                 925             


Pro Leu His Val Ala Ala Arg Asn Gly Leu Thr Met Val Val Gln Glu 
    930                 935                 940                 


Leu Leu Gly Lys Gly Ala Ser Val Leu Ala Val Asp Glu Asn Gly Tyr 
945                 950                 955                 960 


Thr Pro Ala Leu Ala Cys Ala Pro Asn Lys Asp Val Ala Asp Cys Leu 
                965                 970                 975     


Ala Leu Ile Leu Ala Thr Met Met Pro Val Ser Ser Ser Ser Pro Leu 
            980                 985                 990         


Ser Ser Leu Thr Phe Asn Ala Ile  Asn Arg Tyr Thr Asn  Thr Ser Lys 
        995                 1000                 1005             


Thr Val  Ser Phe Glu Ala Leu  Pro Ile Met Arg Asn  Glu Pro Ser 
    1010                 1015                 1020             


Ser Tyr  Cys Ser Phe Asn Asn  Ile Gly Gly Glu Gln  Glu Tyr Leu 
    1025                 1030                 1035             


Tyr Thr  Asp Val Asp Glu Leu  Asn Asp Ser Asp Ser  Glu Thr Tyr 
    1040                 1045                 1050             


<210>  759
<211>  4739
<212>  DNA
<213>  Homosapiens

<400>  759
gcacaggcag tcccggcgcg gggcaaccac agcgctcagg aggccctgag tccggcacct     60

ggccatgtgc aaccctgagg aggcagctct gctgcggctg gaggaggtct tctcagccac    120

cctcgcccat gtcaacagcc ttgtcctcca gcccctgctc ccagccgccc cagatccctc    180

ggatccctgg ggcagagagt gcctgcggct cttgcaacag ctgcacaaga gctcccagca    240

actctgggag gtgacggagg aaagcctgca ctcactgcag gagaggctgc gttacccgga    300

ctccaccggt ctggagtccc tgctgctgct gcgaggtgct gaccgtgtac tgcaggccca    360

catagagtac attgagtcct acacaagctg catggtggtg caggccttcc agaaggcagc    420

aaagaggaga agcgagtact ggcggggcca gcggaaggcg ctgcggcagc tgctttcagg    480

tgtgagctca gagggctcgg tgggcgcatc gctgggccag gccctccacc agccactcgc    540

ccatcacgtg caacagtacg tgctcctcct gctgagcctc ggggacacca ttggggagca    600

tcacccaacc cgggagctgg tggtgaacgc agtcaccctc tttgggaacc tgcagtcctt    660

catgaagcag gagttggacc aggctgtggc cacacaggct ctctggcaca ccctgagagg    720

ccggctgagg gatgtgctct gcacccctgc tcacagactc cttcaggaca gccaggacgt    780

acccgtgacg gtcgcaccgt tgcgggctga gcgtgtgctg ctctttgatg atgccctcgt    840

cctgctgcag ggccacaatg tccacacctt tgatctgaag ctggtgtggg tggatcctgg    900

gcaggacggg tgcacgtttc acctcctcac gcccgaagaa gagttctcct tttgtgccaa    960

ggactcccag ggccaggcag tctggcagtg gaaggtgacc tgggctgttc accaggccct   1020

gcatgggaag aaggacttcc ccgtgctggg ggctggcctg gagccctccc agcctcccga   1080

ctgccgctgc gcagaatata ccttccaggc agagggccgg ctctgccagg ccacctacga   1140

gggcgagtgg tgcaggggcc ggccccacgg caagggaacc ctgaaatggc cggatgggcg   1200

gaatcacgtg gggaatttct gccagggcct ggagcatggc ttcggcatcc gcctgctgcc   1260

ccaggcctct gaggacaagt tcgactgtta caagtgtcac tggcgagaag gcagcatgtg   1320

tggctacggc atctgtgagt acagcaccga cgaggtgtac aagggctact tccaggaggg   1380

cctgcggcac ggatttgggg tccttgagag tggtccgcag gccccccagc ccttcaggta   1440

cacgggccac tgggagaggg gccagaggag cggctatggc attgaggagg atggtgacag   1500

aggtgagcgc tacattggca tgtggcaggc tggtcagcgc cacggcccag gggtcatggt   1560

cacccaggca ggtgtctgct accagggcac cttccaggcg gacaagacgg tgggcccggg   1620

catcctcctc tctgaagacg actccctgta tgagggcacc ttcaccaggg acctgaccct   1680

catggggaag ggcaaggtca ccttccccaa tggcttcacc ctggagggct cgttcggcag   1740

tggggcaggg agaggactgc acacacaggg tgtgctggac acggctgccc tcccaccaga   1800

cccgagcagt acctgcaaga ggcagctggg cgtgggtgcc ttccccgtgg aaagccgctg   1860

gcagggagtc tacagcccct tccgggactt tgtgtgtgct ggctgcccca gggacctgca   1920

ggaggccctg ctgggcttcg acgtgcagag ctccagggag ctgcgtaggt ctcaggatta   1980

cctgtcctgc gagaggaccc accctgagga cagtgtgggc agtatggaag acatcctgga   2040

ggagctgctg cagcaccggg agcccaaggc cctgcagctg tacctcagga aggctctgag   2100

caactcactg caccccctgg gaaagctgct ccggacactg atgctgacct tccaggctac   2160

ctacgcaggt gtcggggcca acaagcacct gcaggagctg gcccaggagg aggtgaagca   2220

gcatgcccag gaactctggg ctgcctacag gggtctgctg cgagttgcct tagagcgcaa   2280

gggccaggcc ctggaggagg atgaagacac agagacaagg gacctccagg tgcatggatt   2340

ggtgctgccc ctcatgctgc ccagcttcta ctcagagctc ttcacgctct acctgctgct   2400

tcatgagcgg gaggacagct tctacagcca gggcattgcc aacttgagcc tctttcctga   2460

tacccaactg ctcgagttcc tggatgtgca gaagcacttg tggcccctca aggacctcac   2520

gctgacgagc aatcagaggt actccctggt cagggacaag tgtttcctgt cagccaccga   2580

gtgcctgcag aagatcatga ccacggtgga cccacgggag aagctggagg tgctggagag   2640

gacatacggg gaaattgagg gcacggtgtc gagggtattg ggccgggagt acaagctgcc   2700

catggacgac ctgctgccac ttctcatcta cgtggtgtcg cgcgcccgaa ttcagcacct   2760

gggagccgag atccacctga tccgtgacat gatggacccc aaccacacag gaggcctgta   2820

tgacttcctg ctcacagccc tggagtcctg ttacgagcac atccagaaag aagacatgag   2880

gctgcaccgc ttacctggcc actggcactc cagggagctc tggtagcctg gcctttcctg   2940

gacagactga agagctgagc agggcactgc cagcctgtcc ctcattaccc aaggcaaggg   3000

gcaggacagg ccctcagaag cagctcttgg aggagatgag cattttgttt tgcacaggaa   3060

gatgctgctg ctgccctgac tgggatgagg gtgaggggtg acgggtgtgg ccctggatgt   3120

ggtggttttc ccttggccac tagcccatct tcaatgaccc cttaatctgc agcagctcac   3180

aggctggggg tgaggagtcc ctggcttctc ttagcctgag cctttctccc aagttccaga   3240

gcctctccgg gcctcagtgc tgccatctgt acaatggtgg agtgagtacg ctgtaaagga   3300

ccttccattc attttgctga attccagagt ccttttggaa aactgacttt agtctgctgg   3360

gctgtattga cctctggcag gctcgaagcc tcactgggta tgcagtcaac aggatgggcc   3420

tggagatccg tgaactgcag gccacgtacc catgacgtaa acggcggcac tggagcaagc   3480

tggggcgggg ggtgggtaaa ccctcactgc cagcaggccc caagtggctt gtaaatcatt   3540

ctcctgtgat gtctgtgggc ctgcgtgggg acaacagggg cacatgacat ctgcctgggc   3600

cctgaccaat aaaccctcag acccaggacc caggaccctg ctgtagttgg ggagcaggag   3660

tacctttggg aggggaggac tttatttaaa cagtggttct agtgtgggac caagagaggc   3720

aggagctggg tcttggggca gctttattcc tgttgggcct cagtttctct tccccacaca   3780

gtttatcttc cgtcacattg tgccgggtga cgtgcacggt ctccctctgc cctagccgga   3840

gatgcatgat gacaggcagt gtgatgtgtt ctgaaagtgt ccagggcaaa gcgtagggag   3900

agggtggatt tgtgcagggt gcagctctgg agaagaagct ggatcactct tggtcccatt   3960

ccctaggccc tgagcaagtc aggctcctgg ctctgggtgt ggctccccca aacgaagtac   4020

tgacttcagc ctgtgagggg agggttgagg gaggctctgg aaagcccagc cacacctgag   4080

tccctggcag tagccttggg gcagagggca cccgcagagt cccagagatg atgtgggcag   4140

tgggcagaga gagccttggc gcctctgttt gccaccactt ccccaggaag gagggacagc   4200

atttctctgg ctggttccac taaatgtgcc agcccaaatg cagggcatgg gctctggttc   4260

tgccaggagc ctgtgacacc cccaggaagg gggtggaact gaggaagagc gaggatatgc   4320

aggcactcat gcttaccggg actggggcag ctcactagga ttctatcctt tccaatcggc   4380

atcagccagc tcttgtcccc tgataagtga ggacagcctg accctggcct caaatgcagc   4440

catccctgag ttcatgcgat gctgacggga ccccagcaca cttccctgcc tcctttgaga   4500

tctgcgagcc cttgctgcag ttcagattca acaaggccct ctgcccaccc tctcactagg   4560

cctcacccaa caccagtgga actggagcct ctggctgggc acagtggctc actttgggag   4620

gctgaggcag gaaggctgct ggaaactgag agttcaagac cagcctgggc aacatagtga   4680

gaccctgtct ctacaaatac aaaataaaat aattagctgg gaaaaaaaaa aaaaaaaaa    4739


<210>  760
<211>  953
<212>  PRT
<213>  Homosapiens

<400>  760

Met Cys Asn Pro Glu Glu Ala Ala Leu Leu Arg Leu Glu Glu Val Phe 
1               5                   10                  15      


Ser Ala Thr Leu Ala His Val Asn Ser Leu Val Leu Gln Pro Leu Leu 
            20                  25                  30          


Pro Ala Ala Pro Asp Pro Ser Asp Pro Trp Gly Arg Glu Cys Leu Arg 
        35                  40                  45              


Leu Leu Gln Gln Leu His Lys Ser Ser Gln Gln Leu Trp Glu Val Thr 
    50                  55                  60                  


Glu Glu Ser Leu His Ser Leu Gln Glu Arg Leu Arg Tyr Pro Asp Ser 
65                  70                  75                  80  


Thr Gly Leu Glu Ser Leu Leu Leu Leu Arg Gly Ala Asp Arg Val Leu 
                85                  90                  95      


Gln Ala His Ile Glu Tyr Ile Glu Ser Tyr Thr Ser Cys Met Val Val 
            100                 105                 110         


Gln Ala Phe Gln Lys Ala Ala Lys Arg Arg Ser Glu Tyr Trp Arg Gly 
        115                 120                 125             


Gln Arg Lys Ala Leu Arg Gln Leu Leu Ser Gly Val Ser Ser Glu Gly 
    130                 135                 140                 


Ser Val Gly Ala Ser Leu Gly Gln Ala Leu His Gln Pro Leu Ala His 
145                 150                 155                 160 


His Val Gln Gln Tyr Val Leu Leu Leu Leu Ser Leu Gly Asp Thr Ile 
                165                 170                 175     


Gly Glu His His Pro Thr Arg Glu Leu Val Val Asn Ala Val Thr Leu 
            180                 185                 190         


Phe Gly Asn Leu Gln Ser Phe Met Lys Gln Glu Leu Asp Gln Ala Val 
        195                 200                 205             


Ala Thr Gln Ala Leu Trp His Thr Leu Arg Gly Arg Leu Arg Asp Val 
    210                 215                 220                 


Leu Cys Thr Pro Ala His Arg Leu Leu Gln Asp Ser Gln Asp Val Pro 
225                 230                 235                 240 


Val Thr Val Ala Pro Leu Arg Ala Glu Arg Val Leu Leu Phe Asp Asp 
                245                 250                 255     


Ala Leu Val Leu Leu Gln Gly His Asn Val His Thr Phe Asp Leu Lys 
            260                 265                 270         


Leu Val Trp Val Asp Pro Gly Gln Asp Gly Cys Thr Phe His Leu Leu 
        275                 280                 285             


Thr Pro Glu Glu Glu Phe Ser Phe Cys Ala Lys Asp Ser Gln Gly Gln 
    290                 295                 300                 


Ala Val Trp Gln Trp Lys Val Thr Trp Ala Val His Gln Ala Leu His 
305                 310                 315                 320 


Gly Lys Lys Asp Phe Pro Val Leu Gly Ala Gly Leu Glu Pro Ser Gln 
                325                 330                 335     


Pro Pro Asp Cys Arg Cys Ala Glu Tyr Thr Phe Gln Ala Glu Gly Arg 
            340                 345                 350         


Leu Cys Gln Ala Thr Tyr Glu Gly Glu Trp Cys Arg Gly Arg Pro His 
        355                 360                 365             


Gly Lys Gly Thr Leu Lys Trp Pro Asp Gly Arg Asn His Val Gly Asn 
    370                 375                 380                 


Phe Cys Gln Gly Leu Glu His Gly Phe Gly Ile Arg Leu Leu Pro Gln 
385                 390                 395                 400 


Ala Ser Glu Asp Lys Phe Asp Cys Tyr Lys Cys His Trp Arg Glu Gly 
                405                 410                 415     


Ser Met Cys Gly Tyr Gly Ile Cys Glu Tyr Ser Thr Asp Glu Val Tyr 
            420                 425                 430         


Lys Gly Tyr Phe Gln Glu Gly Leu Arg His Gly Phe Gly Val Leu Glu 
        435                 440                 445             


Ser Gly Pro Gln Ala Pro Gln Pro Phe Arg Tyr Thr Gly His Trp Glu 
    450                 455                 460                 


Arg Gly Gln Arg Ser Gly Tyr Gly Ile Glu Glu Asp Gly Asp Arg Gly 
465                 470                 475                 480 


Glu Arg Tyr Ile Gly Met Trp Gln Ala Gly Gln Arg His Gly Pro Gly 
                485                 490                 495     


Val Met Val Thr Gln Ala Gly Val Cys Tyr Gln Gly Thr Phe Gln Ala 
            500                 505                 510         


Asp Lys Thr Val Gly Pro Gly Ile Leu Leu Ser Glu Asp Asp Ser Leu 
        515                 520                 525             


Tyr Glu Gly Thr Phe Thr Arg Asp Leu Thr Leu Met Gly Lys Gly Lys 
    530                 535                 540                 


Val Thr Phe Pro Asn Gly Phe Thr Leu Glu Gly Ser Phe Gly Ser Gly 
545                 550                 555                 560 


Ala Gly Arg Gly Leu His Thr Gln Gly Val Leu Asp Thr Ala Ala Leu 
                565                 570                 575     


Pro Pro Asp Pro Ser Ser Thr Cys Lys Arg Gln Leu Gly Val Gly Ala 
            580                 585                 590         


Phe Pro Val Glu Ser Arg Trp Gln Gly Val Tyr Ser Pro Phe Arg Asp 
        595                 600                 605             


Phe Val Cys Ala Gly Cys Pro Arg Asp Leu Gln Glu Ala Leu Leu Gly 
    610                 615                 620                 


Phe Asp Val Gln Ser Ser Arg Glu Leu Arg Arg Ser Gln Asp Tyr Leu 
625                 630                 635                 640 


Ser Cys Glu Arg Thr His Pro Glu Asp Ser Val Gly Ser Met Glu Asp 
                645                 650                 655     


Ile Leu Glu Glu Leu Leu Gln His Arg Glu Pro Lys Ala Leu Gln Leu 
            660                 665                 670         


Tyr Leu Arg Lys Ala Leu Ser Asn Ser Leu His Pro Leu Gly Lys Leu 
        675                 680                 685             


Leu Arg Thr Leu Met Leu Thr Phe Gln Ala Thr Tyr Ala Gly Val Gly 
    690                 695                 700                 


Ala Asn Lys His Leu Gln Glu Leu Ala Gln Glu Glu Val Lys Gln His 
705                 710                 715                 720 


Ala Gln Glu Leu Trp Ala Ala Tyr Arg Gly Leu Leu Arg Val Ala Leu 
                725                 730                 735     


Glu Arg Lys Gly Gln Ala Leu Glu Glu Asp Glu Asp Thr Glu Thr Arg 
            740                 745                 750         


Asp Leu Gln Val His Gly Leu Val Leu Pro Leu Met Leu Pro Ser Phe 
        755                 760                 765             


Tyr Ser Glu Leu Phe Thr Leu Tyr Leu Leu Leu His Glu Arg Glu Asp 
    770                 775                 780                 


Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser Leu Phe Pro Asp Thr 
785                 790                 795                 800 


Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His Leu Trp Pro Leu Lys 
                805                 810                 815     


Asp Leu Thr Leu Thr Ser Asn Gln Arg Tyr Ser Leu Val Arg Asp Lys 
            820                 825                 830         


Cys Phe Leu Ser Ala Thr Glu Cys Leu Gln Lys Ile Met Thr Thr Val 
        835                 840                 845             


Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg Thr Tyr Gly Glu Ile 
    850                 855                 860                 


Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu Tyr Lys Leu Pro Met 
865                 870                 875                 880 


Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val Ser Arg Ala Arg Ile 
                885                 890                 895     


Gln His Leu Gly Ala Glu Ile His Leu Ile Arg Asp Met Met Asp Pro 
            900                 905                 910         


Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu Thr Ala Leu Glu Ser 
        915                 920                 925             


Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg Leu His Arg Leu Pro 
    930                 935                 940                 


Gly His Trp His Ser Arg Glu Leu Trp 
945                 950             


<210>  761
<211>  3148
<212>  DNA
<213>  Homosapiens

<400>  761
aggaaggaac cagctgtaag ggagggcaga gggggatgtc ttggagggga atcccagact     60

ttggacactg gtctctcttg gaccaagacc ccctctctgg cttggcctcc agatctgccc    120

acctttctgt ctccgtcttt ccaggattcc atatgcttct gtctgtcttc tcgtcgcagg    180

gtagattctc tgtccctttc tctgctgctc ttcctcctgg agccgtggag gcagctgggc    240

gtgggtgcct tccccgtgga aagccgctgg cagggagtct acagcccctt ccgggacttt    300

gtgtgtgctg gctgccccag ggacctgcag gaggccctgc tgggcttcga cgtgcagagc    360

tccagggagc tgcgtaggtc tcaggattac ctgtcctgcg agaggaccca ccctgaggac    420

agtgtgggca gtatggaaga catcctggag gagctgctgc agcaccggga gcccaaggcc    480

ctgcagctgt acctcaggaa ggctctgagc aactcactgc accccctggg aaagctgctc    540

cggacactga tgctgacctt ccaggctacc tacgcaggtg tcggggccaa caagcacctg    600

caggagctgg cccaggagga ggtgaagcag catgcccagg aactctgggc tgcctacagg    660

ggtctgctgc gagttgcctt agagcgcaag ggccaggccc tggaggagga tgaagacaca    720

gagacaaggg acctccaggt gcatggattg gtgctgcccc tcatgctgcc cagcttctac    780

tcagagctct tcacgctcta cctgctgctt catgagcggg aggacagctt ctacagccag    840

ggcattgcca acttgagcct ctttcctgat acccaactgc tcgagttcct ggatgtgcag    900

aagcacttgt ggcccctcaa ggacctcacg ctgacgagca atcagaggta ctccctggtc    960

agggacaagt gtttcctgtc agccaccgag tgcctgcaga agatcatgac cacggtggac   1020

ccacgggaga agctggaggt gctggagagg acatacgggg aaattgaggg cacggtgtcg   1080

agggtattgg gccgggagta caagctgccc atggacgacc tgctgccact tctcatctac   1140

gtggtgtcgc gcgcccgaat tcagcacctg ggagccgaga tccacctgat ccgtgacatg   1200

atggacccca accacacagg aggcctgtat gacttcctgc tcacagccct ggagtcctgt   1260

tacgagcaca tccagaaaga agacatgagg ctgcaccgct tacctggcca ctggcactcc   1320

agggagctct ggtagcctgg cctttcctgg acagactgaa gagctgagca gggcactgcc   1380

agcctgtccc tcattaccca aggcaagggg caggacaggc cctcagaagc agctcttgga   1440

ggagatgagc attttgtttt gcacaggaag atgctgctgc tgccctgact gggatgaggg   1500

tgaggggtga cgggtgtggc cctggatgtg gtggttttcc cttggccact agcccatctt   1560

caatgacccc ttaatctgca gcagctcaca ggctgggggt gaggagtccc tggcttctct   1620

tagcctgagc ctttctccca agttccagag cctctccggg cctcagtgct gccatctgta   1680

caatggtgga gtgagtacgc tgtaaaggac cttccattca ttttgctgaa ttccagagtc   1740

cttttggaaa actgacttta gtctgctggg ctgtattgac ctctggcagg ctcgaagcct   1800

cactgggtat gcagtcaaca ggatgggcct ggagatccgt gaactgcagg ccacgtaccc   1860

atgacgtaaa cggcggcact ggagcaagct ggggcggggg gtgggtaaac cctcactgcc   1920

agcaggcccc aagtggcttg taaatcattc tcctgtgatg tctgtgggcc tgcgtgggga   1980

caacaggggc acatgacatc tgcctgggcc ctgaccaata aaccctcaga cccaggaccc   2040

aggaccctgc tgtagttggg gagcaggagt acctttggga ggggaggact ttatttaaac   2100

agtggttcta gtgtgggacc aagagaggca ggagctgggt cttggggcag ctttattcct   2160

gttgggcctc agtttctctt ccccacacag tttatcttcc gtcacattgt gccgggtgac   2220

gtgcacggtc tccctctgcc ctagccggag atgcatgatg acaggcagtg tgatgtgttc   2280

tgaaagtgtc cagggcaaag cgtagggaga gggtggattt gtgcagggtg cagctctgga   2340

gaagaagctg gatcactctt ggtcccattc cctaggccct gagcaagtca ggctcctggc   2400

tctgggtgtg gctcccccaa acgaagtact gacttcagcc tgtgagggga gggttgaggg   2460

aggctctgga aagcccagcc acacctgagt ccctggcagt agccttgggg cagagggcac   2520

ccgcagagtc ccagagatga tgtgggcagt gggcagagag agccttggcg cctctgtttg   2580

ccaccacttc cccaggaagg agggacagca tttctctggc tggttccact aaatgtgcca   2640

gcccaaatgc agggcatggg ctctggttct gccaggagcc tgtgacaccc ccaggaaggg   2700

ggtggaactg aggaagagcg aggatatgca ggcactcatg cttaccggga ctggggcagc   2760

tcactaggat tctatccttt ccaatcggca tcagccagct cttgtcccct gataagtgag   2820

gacagcctga ccctggcctc aaatgcagcc atccctgagt tcatgcgatg ctgacgggac   2880

cccagcacac ttccctgcct cctttgagat ctgcgagccc ttgctgcagt tcagattcaa   2940

caaggccctc tgcccaccct ctcactaggc ctcacccaac accagtggaa ctggagcctc   3000

tggctgggca cagtggctca ctttgggagg ctgaggcagg aaggctgctg gaaactgaga   3060

gttcaagacc agcctgggca acatagtgag accctgtctc tacaaataca aaataaaata   3120

attagctggg aaaaaaaaaa aaaaaaaa                                      3148


<210>  762
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  762

Met Glu Asp Ile Leu Glu Glu Leu Leu Gln His Arg Glu Pro Lys Ala 
1               5                   10                  15      


Leu Gln Leu Tyr Leu Arg Lys Ala Leu Ser Asn Ser Leu His Pro Leu 
            20                  25                  30          


Gly Lys Leu Leu Arg Thr Leu Met Leu Thr Phe Gln Ala Thr Tyr Ala 
        35                  40                  45              


Gly Val Gly Ala Asn Lys His Leu Gln Glu Leu Ala Gln Glu Glu Val 
    50                  55                  60                  


Lys Gln His Ala Gln Glu Leu Trp Ala Ala Tyr Arg Gly Leu Leu Arg 
65                  70                  75                  80  


Val Ala Leu Glu Arg Lys Gly Gln Ala Leu Glu Glu Asp Glu Asp Thr 
                85                  90                  95      


Glu Thr Arg Asp Leu Gln Val His Gly Leu Val Leu Pro Leu Met Leu 
            100                 105                 110         


Pro Ser Phe Tyr Ser Glu Leu Phe Thr Leu Tyr Leu Leu Leu His Glu 
        115                 120                 125             


Arg Glu Asp Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser Leu Phe 
    130                 135                 140                 


Pro Asp Thr Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His Leu Trp 
145                 150                 155                 160 


Pro Leu Lys Asp Leu Thr Leu Thr Ser Asn Gln Arg Tyr Ser Leu Val 
                165                 170                 175     


Arg Asp Lys Cys Phe Leu Ser Ala Thr Glu Cys Leu Gln Lys Ile Met 
            180                 185                 190         


Thr Thr Val Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg Thr Tyr 
        195                 200                 205             


Gly Glu Ile Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu Tyr Lys 
    210                 215                 220                 


Leu Pro Met Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val Ser Arg 
225                 230                 235                 240 


Ala Arg Ile Gln His Leu Gly Ala Glu Ile His Leu Ile Arg Asp Met 
                245                 250                 255     


Met Asp Pro Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu Thr Ala 
            260                 265                 270         


Leu Glu Ser Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg Leu His 
        275                 280                 285             


Arg Leu Pro Gly His Trp His Ser Arg Glu Leu Trp 
    290                 295                 300 


<210>  763
<211>  1646
<212>  DNA
<213>  Homosapiens

<400>  763
ggcggcgcgg gaacctgaca ccgaggatga ataaatgatg ctcgctgact acccgtggcc     60

aaagcccgtg gccaccgagc gccggctggc aggggcagtg accggcggcc ggcccgttcg    120

tccctgggct ccgcaagcgg cgcggtggca cgaagatggc ggggtggccg ggcgcgggtc    180

ccctctgcgt gctgggcggc gccgcactcg gggtgtgcct cgcgggggtt gccgggcagc    240

tggtggagcc cagcacggcc ccacccaagc ccaagccgcc tccgctgacc aaggagacag    300

tggtgttctg ggacatgcgc ctgtggcacg tggtgggcat cttttcgctc ttcgtgttgt    360

ccatcatcat cacgctgtgc tgtgtcttca actgtcgtgt gccacggacc cggaaggaga    420

tcgaagcccg gtacctgcag cgaaaggcag ccaagatgta cacagacaag ctggagactg    480

tgccacccct caatgagctc acagaagtcc caggagagga taagaagaag aagaagaaga    540

agaaggacag tgtggacaca gtggccatca aagtagagga ggatgagaag aatgaggcca    600

agaagaagaa aggagagaaa tgaagacatc ctgggcagct tgggctggcg ggccctggag    660

ctcaagccgt ggccggggtc caggcatgtt ggactctgag ctcatttggg gaccacagag    720

gctgtggtca gagagggaag ctgaggccca tggccacatc ctcatggccc atcaggggca    780

ggaaccagac aatctcgtag gtgtcctgcc ccccagccta ggcttggctc ctttcacccc    840

atccacatgg gtactgtctc ggcagaggtg gtctggtgcc accgtccctc tgcagataca    900

ctgctctccc cacccagacc tgcctgtctc ccaccctttc tgccagggat ggcagtggct    960

gtgaaggagt aatgggatat ggggttactt cagccaccct ttctggcacg aaatggctga   1020

agtgcatggg tcagggtgtg aggccacacc cagagtagcc atgaggaggc agagagggtc   1080

actgggggac actgtggcag caggagggac tctgtctggc cagggaggag ccccagtggt   1140

gagaagactt ccccaagcct ggcaggggat ccagctcaag ggagtaagta gaggtggctt   1200

cagaaatgga acccccagcc cagcagacat caagctcaag gcaatgggct accctcattt   1260

cacacgttgt gatgaagctg aggctgctgc caggcccggc atgaggcccc gaggctcgag   1320

ctcggggctg ggggctgcag ggctgggtca ggggtacaca gagctaaggc caatgggcta   1380

gagggtgccg gaaagagagc tggagtctgg gctcctcttg ggaatcagag tatatttaag   1440

aagccaaggg ggacctcggg ctgttctggt ggccccttct atgcccagct gtgctgggag   1500

gtcccagggc cctagaagat cacagcaggg ccttctgcct gctgaccata acagtgccag   1560

cttctttgca gcttcctctt ctaccatttc ccactacggg cacctaaaag aagcatctct   1620

gaccagaaga caaaggccca aatagc                                        1646


<210>  764
<211>  155
<212>  PRT
<213>  Homosapiens

<400>  764

Met Ala Gly Trp Pro Gly Ala Gly Pro Leu Cys Val Leu Gly Gly Ala 
1               5                   10                  15      


Ala Leu Gly Val Cys Leu Ala Gly Val Ala Gly Gln Leu Val Glu Pro 
            20                  25                  30          


Ser Thr Ala Pro Pro Lys Pro Lys Pro Pro Pro Leu Thr Lys Glu Thr 
        35                  40                  45              


Val Val Phe Trp Asp Met Arg Leu Trp His Val Val Gly Ile Phe Ser 
    50                  55                  60                  


Leu Phe Val Leu Ser Ile Ile Ile Thr Leu Cys Cys Val Phe Asn Cys 
65                  70                  75                  80  


Arg Val Pro Arg Thr Arg Lys Glu Ile Glu Ala Arg Tyr Leu Gln Arg 
                85                  90                  95      


Lys Ala Ala Lys Met Tyr Thr Asp Lys Leu Glu Thr Val Pro Pro Leu 
            100                 105                 110         


Asn Glu Leu Thr Glu Val Pro Gly Glu Asp Lys Lys Lys Lys Lys Lys 
        115                 120                 125             


Lys Lys Asp Ser Val Asp Thr Val Ala Ile Lys Val Glu Glu Asp Glu 
    130                 135                 140                 


Lys Asn Glu Ala Lys Lys Lys Lys Gly Glu Lys 
145                 150                 155 


<210>  765
<211>  1354
<212>  DNA
<213>  Homosapiens

<400>  765
agcggactgg gagcgccttc cggagagacg cagtcggctg ccaccccggg atgggtcgct     60

ggtgccagac cgtcgcgcgc gggcagcgcc cccggacgtc tgccccctcc cgcgccggtg    120

ccctgctgct gctgcttctg ttgctgaggt ctgcaggttg ctggggcgca ggggaagccc    180

cgggggcgct gtccactgct gatcccgccg accagagcgt ccagtgtgtc cccaaggcca    240

cctgtccttc cagccggcct cgccttctct ggcagacccc gaccacccag acactgccct    300

cgaccaccat ggagacccaa ttcccagttt ctgaaggcaa agtcgaccca taccgctcct    360

gtggcttttc ctacgagcag gaccccaccc tcagggaccc agaagccgtg gctcggcggt    420

ggccctggat ggtcagcgtg cgggccaatg gcacacacat ctgtgccggc accatcattg    480

cctcccagtg ggtgctgact gtggcccact gcctgatctg gcgtgatgtt atctactcag    540

tgagggtggg gagtccgtgg attgaccaga tgacgcagac cgcctccgat gtcccggtgc    600

tccaggtcat catgcatagc aggtaccggg cccagcggtt ctggtcctgg gtgggccagg    660

ccaacgacat cggcctcctc aagctcaagc aggaactcaa gtacagcaat tacgtgcggc    720

ccatctgcct gcctggcacg gactatgtgt tgaaggacca ttcccgctgc actgtgacgg    780

gctggggact ttccaaggct gacggcatgt ggcctcagtt ccggaccatt caggagaagg    840

aagtcatcat cctgaacaac aaagagtgtg acaatttcta ccacaacttc accaaaatcc    900

ccactctggt tcagatcatc aagtcccaga tgatgtgtgc ggaggacacc cacagggaga    960

agttctgcta tgagctaact ggagagccct tggtctgctc catggagggc acgtggtacc   1020

tggtgggatt ggtgagctgg ggtgcaggct gccagaagag cgaggcccca cccatctacc   1080

tacaggtctc ctcctaccaa cactggatct gggactgcct caacgggcag gccctggccc   1140

tgccagcccc atccaggacc ctgctcctgg cactcccact gcccctcagc ctccttgctg   1200

ccctctgact ctgtgtgccc tccctcactt gtgggccccc cttgcctccg tgcccaggtt   1260

gctgtaggtg cagctgtcac agccctgaga gtcagggtgg agatgaggtg ctcaattaaa   1320

cattactgtt ttccatgcaa aaaaaaaaaa aaaa                               1354


<210>  766
<211>  385
<212>  PRT
<213>  Homosapiens

<400>  766

Met Gly Arg Trp Cys Gln Thr Val Ala Arg Gly Gln Arg Pro Arg Thr 
1               5                   10                  15      


Ser Ala Pro Ser Arg Ala Gly Ala Leu Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Arg Ser Ala Gly Cys Trp Gly Ala Gly Glu Ala Pro Gly Ala Leu Ser 
        35                  40                  45              


Thr Ala Asp Pro Ala Asp Gln Ser Val Gln Cys Val Pro Lys Ala Thr 
    50                  55                  60                  


Cys Pro Ser Ser Arg Pro Arg Leu Leu Trp Gln Thr Pro Thr Thr Gln 
65                  70                  75                  80  


Thr Leu Pro Ser Thr Thr Met Glu Thr Gln Phe Pro Val Ser Glu Gly 
                85                  90                  95      


Lys Val Asp Pro Tyr Arg Ser Cys Gly Phe Ser Tyr Glu Gln Asp Pro 
            100                 105                 110         


Thr Leu Arg Asp Pro Glu Ala Val Ala Arg Arg Trp Pro Trp Met Val 
        115                 120                 125             


Ser Val Arg Ala Asn Gly Thr His Ile Cys Ala Gly Thr Ile Ile Ala 
    130                 135                 140                 


Ser Gln Trp Val Leu Thr Val Ala His Cys Leu Ile Trp Arg Asp Val 
145                 150                 155                 160 


Ile Tyr Ser Val Arg Val Gly Ser Pro Trp Ile Asp Gln Met Thr Gln 
                165                 170                 175     


Thr Ala Ser Asp Val Pro Val Leu Gln Val Ile Met His Ser Arg Tyr 
            180                 185                 190         


Arg Ala Gln Arg Phe Trp Ser Trp Val Gly Gln Ala Asn Asp Ile Gly 
        195                 200                 205             


Leu Leu Lys Leu Lys Gln Glu Leu Lys Tyr Ser Asn Tyr Val Arg Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Thr Asp Tyr Val Leu Lys Asp His Ser Arg Cys 
225                 230                 235                 240 


Thr Val Thr Gly Trp Gly Leu Ser Lys Ala Asp Gly Met Trp Pro Gln 
                245                 250                 255     


Phe Arg Thr Ile Gln Glu Lys Glu Val Ile Ile Leu Asn Asn Lys Glu 
            260                 265                 270         


Cys Asp Asn Phe Tyr His Asn Phe Thr Lys Ile Pro Thr Leu Val Gln 
        275                 280                 285             


Ile Ile Lys Ser Gln Met Met Cys Ala Glu Asp Thr His Arg Glu Lys 
    290                 295                 300                 


Phe Cys Tyr Glu Leu Thr Gly Glu Pro Leu Val Cys Ser Met Glu Gly 
305                 310                 315                 320 


Thr Trp Tyr Leu Val Gly Leu Val Ser Trp Gly Ala Gly Cys Gln Lys 
                325                 330                 335     


Ser Glu Ala Pro Pro Ile Tyr Leu Gln Val Ser Ser Tyr Gln His Trp 
            340                 345                 350         


Ile Trp Asp Cys Leu Asn Gly Gln Ala Leu Ala Leu Pro Ala Pro Ser 
        355                 360                 365             


Arg Thr Leu Leu Leu Ala Leu Pro Leu Pro Leu Ser Leu Leu Ala Ala 
    370                 375                 380                 


Leu 
385 


<210>  767
<211>  783
<212>  DNA
<213>  Homosapiens

<400>  767
atgacccgcc attggccctg ggaggtgagc ctccggatgg aaaatgagca cgtgtgtgga     60

ggggccctca ttgaccccag ctgggtggtg actgcggccc actgcatcca aggcaccaaa    120

gagtactcag tggtgcttgg cacctccaag ctgcagccca tgaacttcag cagggccctc    180

tgggtccctg tgagggacat cattatgcac cccaagtact ggggccgggc cttcatcatg    240

ggtgacgttg cccttgtcca ccttcaaaca cctgtcacct tcagtgagta cgtgcagccc    300

atctgcctcc cggagcccaa tttcaacctg aaggttggga cgcagtgttg ggtgactggc    360

tggagccagg ttaagcagcg cttttcagcc aactccatgc tgaccccaga gctgcaggag    420

gctgaggtgt ttatcatgga caacaagagg tgtgaccggc attacaagaa gtccttcttc    480

cccccagttg tcccccttgt cctgggggac atgatctgtg ccaccaatta tggggaaaac    540

ttgtgctatg gggattctgg agggccattg gcttgtgaag ttgagggcag atggattctg    600

gctggggtgt tgtcctggga aaaggcctgc gtgaaggcac agaatccagg tgtgtacacc    660

cgcatcacca aatacaccaa atggatcaag aagcaaatga gcaatggagc cttctcaggt    720

ccctgtgcct ctgcctgcct cctgttcctg tgctggctgc tgcagcccca gatgggctcc    780

tga                                                                  783


<210>  768
<211>  260
<212>  PRT
<213>  Homosapiens

<400>  768

Met Thr Arg His Trp Pro Trp Glu Val Ser Leu Arg Met Glu Asn Glu 
1               5                   10                  15      


His Val Cys Gly Gly Ala Leu Ile Asp Pro Ser Trp Val Val Thr Ala 
            20                  25                  30          


Ala His Cys Ile Gln Gly Thr Lys Glu Tyr Ser Val Val Leu Gly Thr 
        35                  40                  45              


Ser Lys Leu Gln Pro Met Asn Phe Ser Arg Ala Leu Trp Val Pro Val 
    50                  55                  60                  


Arg Asp Ile Ile Met His Pro Lys Tyr Trp Gly Arg Ala Phe Ile Met 
65                  70                  75                  80  


Gly Asp Val Ala Leu Val His Leu Gln Thr Pro Val Thr Phe Ser Glu 
                85                  90                  95      


Tyr Val Gln Pro Ile Cys Leu Pro Glu Pro Asn Phe Asn Leu Lys Val 
            100                 105                 110         


Gly Thr Gln Cys Trp Val Thr Gly Trp Ser Gln Val Lys Gln Arg Phe 
        115                 120                 125             


Ser Ala Asn Ser Met Leu Thr Pro Glu Leu Gln Glu Ala Glu Val Phe 
    130                 135                 140                 


Ile Met Asp Asn Lys Arg Cys Asp Arg His Tyr Lys Lys Ser Phe Phe 
145                 150                 155                 160 


Pro Pro Val Val Pro Leu Val Leu Gly Asp Met Ile Cys Ala Thr Asn 
                165                 170                 175     


Tyr Gly Glu Asn Leu Cys Tyr Gly Asp Ser Gly Gly Pro Leu Ala Cys 
            180                 185                 190         


Glu Val Glu Gly Arg Trp Ile Leu Ala Gly Val Leu Ser Trp Glu Lys 
        195                 200                 205             


Ala Cys Val Lys Ala Gln Asn Pro Gly Val Tyr Thr Arg Ile Thr Lys 
    210                 215                 220                 


Tyr Thr Lys Trp Ile Lys Lys Gln Met Ser Asn Gly Ala Phe Ser Gly 
225                 230                 235                 240 


Pro Cys Ala Ser Ala Cys Leu Leu Phe Leu Cys Trp Leu Leu Gln Pro 
                245                 250                 255     


Gln Met Gly Ser 
            260 


<210>  769
<211>  882
<212>  DNA
<213>  Homosapiens

<400>  769
atgtcctctg gcggcggctc ccggggcctc ctggcgtggc ttctgctcct tcagccctgg     60

cccgggcaga actgggcggg catggcggcg ccacgcctcc cgtcccctct cctctcagag    120

gagggcggcg agaaccccga agcgagcccg gctccaggac ctgaagcggg ccccccactc    180

aatctgttta cgtcctttcc aggtgactca ctgctgtgtg gccgaacccc tctgagaatc    240

gtgggaggag tggacgcgga ggaagggagg tggccctggc aggtgagcgt gaggaccaaa    300

ggcaggcaca tctgcggcgg caccctggtc accgccacgt gggtgctgac ggcaggccac    360

tgcatttcca gccgtttcca ttacagtgtc aagatgggag atcggagtgt ctataatgaa    420

aacacaagtg tggtggtctc agtccaaaga gcttttgtcc accctaagtt ctcaacagtt    480

acaaccattc gaaatgacct tgcccttctc cagctccaac atcctgtgaa ttttacctca    540

aacatccagc ctatctgcat ccctcaggag aatttccagg tggaaggtag gaccaggtgc    600

tgggtgaccg gatggggcaa aacaccagaa cgagagaaac ttgcatcaga aattcttcag    660

gatgtggacc aatacatcat gtgctatgag gaatgtaata agataataca gaaggccttg    720

tcatctacta aggatgtaat aataaaaggg atggtctgtg gctataaaga acaaggaaag    780

gattcttgtc aaggagattc tgggggccgc ttggcctgtg aatataatga cacatgggtc    840

caggtaggga ttgtgagctg gggcatcggc tgtggtcgct ga                       882


<210>  770
<211>  293
<212>  PRT
<213>  Homosapiens

<400>  770

Met Ser Ser Gly Gly Gly Ser Arg Gly Leu Leu Ala Trp Leu Leu Leu 
1               5                   10                  15      


Leu Gln Pro Trp Pro Gly Gln Asn Trp Ala Gly Met Ala Ala Pro Arg 
            20                  25                  30          


Leu Pro Ser Pro Leu Leu Ser Glu Glu Gly Gly Glu Asn Pro Glu Ala 
        35                  40                  45              


Ser Pro Ala Pro Gly Pro Glu Ala Gly Pro Pro Leu Asn Leu Phe Thr 
    50                  55                  60                  


Ser Phe Pro Gly Asp Ser Leu Leu Cys Gly Arg Thr Pro Leu Arg Ile 
65                  70                  75                  80  


Val Gly Gly Val Asp Ala Glu Glu Gly Arg Trp Pro Trp Gln Val Ser 
                85                  90                  95      


Val Arg Thr Lys Gly Arg His Ile Cys Gly Gly Thr Leu Val Thr Ala 
            100                 105                 110         


Thr Trp Val Leu Thr Ala Gly His Cys Ile Ser Ser Arg Phe His Tyr 
        115                 120                 125             


Ser Val Lys Met Gly Asp Arg Ser Val Tyr Asn Glu Asn Thr Ser Val 
    130                 135                 140                 


Val Val Ser Val Gln Arg Ala Phe Val His Pro Lys Phe Ser Thr Val 
145                 150                 155                 160 


Thr Thr Ile Arg Asn Asp Leu Ala Leu Leu Gln Leu Gln His Pro Val 
                165                 170                 175     


Asn Phe Thr Ser Asn Ile Gln Pro Ile Cys Ile Pro Gln Glu Asn Phe 
            180                 185                 190         


Gln Val Glu Gly Arg Thr Arg Cys Trp Val Thr Gly Trp Gly Lys Thr 
        195                 200                 205             


Pro Glu Arg Glu Lys Leu Ala Ser Glu Ile Leu Gln Asp Val Asp Gln 
    210                 215                 220                 


Tyr Ile Met Cys Tyr Glu Glu Cys Asn Lys Ile Ile Gln Lys Ala Leu 
225                 230                 235                 240 


Ser Ser Thr Lys Asp Val Ile Ile Lys Gly Met Val Cys Gly Tyr Lys 
                245                 250                 255     


Glu Gln Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Arg Leu Ala 
            260                 265                 270         


Cys Glu Tyr Asn Asp Thr Trp Val Gln Val Gly Ile Val Ser Trp Gly 
        275                 280                 285             


Ile Gly Cys Gly Arg 
    290             


<210>  771
<211>  872
<212>  DNA
<213>  Homosapiens

<400>  771
ctgctttctg cattcttctc tccacatgcc tctctgtact tacagcccca atggccccca     60

aaaagccaga gcccaagaag gatgatgcca aggcagcccc caaggcagct ccagctcccg    120

cacctccccc tgagcctgag cgccctaagg aggtcgagtt tgatgcttcc aagatcaaga    180

ttgagttcac acctgagcag attgaagagt tcaaggaagc cttcatgctg ttcgaccgca    240

cacccaagtg tgagatgaag atcacctacg ggcagtgtgg ggatgtcctg cgggcgctgg    300

gccagaaccc cacacaggca gaagtgctcc gtgtcctggg gaagccaaga caggaagagc    360

tcaataccaa gatgatggac tttgaaactt tcctgcctat gctccagcac atttccaaga    420

acaaggacac aggcacctat gaggacttcg tggaggggct gcgggtcttc gacaaggagg    480

gcaatggcac tgtcatgggt gctgagcttc gccacgtgct ggccacgctg ggtgagaggc    540

tgacagaaga cgaagtggag aagttgatgg ctgggcaaga ggactccaat ggctgcatca    600

actatgaagc atttgtgaag cacatcatgt ccagctaaac ctcgtgccca gaagccagga    660

aggctgtgca ggacgtctca tctcccatgt gtgatgctga caccaagcgg cctggagtcg    720

tgggaaggag gggagcctta ccaagactcc tgcaaaaacc cttggacctc tccacgtggt    780

tgccgtctct ggcccctctc aggctgtgct tacctgtgac agcagctctg tccccacccc    840

atgggcctca tgaataaagg cttcttgccg gc                                  872


<210>  772
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  772

Met Ala Pro Lys Lys Pro Glu Pro Lys Lys Asp Asp Ala Lys Ala Ala 
1               5                   10                  15      


Pro Lys Ala Ala Pro Ala Pro Ala Pro Pro Pro Glu Pro Glu Arg Pro 
            20                  25                  30          


Lys Glu Val Glu Phe Asp Ala Ser Lys Ile Lys Ile Glu Phe Thr Pro 
        35                  40                  45              


Glu Gln Ile Glu Glu Phe Lys Glu Ala Phe Met Leu Phe Asp Arg Thr 
    50                  55                  60                  


Pro Lys Cys Glu Met Lys Ile Thr Tyr Gly Gln Cys Gly Asp Val Leu 
65                  70                  75                  80  


Arg Ala Leu Gly Gln Asn Pro Thr Gln Ala Glu Val Leu Arg Val Leu 
                85                  90                  95      


Gly Lys Pro Arg Gln Glu Glu Leu Asn Thr Lys Met Met Asp Phe Glu 
            100                 105                 110         


Thr Phe Leu Pro Met Leu Gln His Ile Ser Lys Asn Lys Asp Thr Gly 
        115                 120                 125             


Thr Tyr Glu Asp Phe Val Glu Gly Leu Arg Val Phe Asp Lys Glu Gly 
    130                 135                 140                 


Asn Gly Thr Val Met Gly Ala Glu Leu Arg His Val Leu Ala Thr Leu 
145                 150                 155                 160 


Gly Glu Arg Leu Thr Glu Asp Glu Val Glu Lys Leu Met Ala Gly Gln 
                165                 170                 175     


Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe Val Lys His Ile 
            180                 185                 190         


Met Ser Ser 
        195 


<210>  773
<211>  2144
<212>  DNA
<213>  Homosapiens

<400>  773
ccacagaagc tgctcaggga ctatccatgg cctccccgtg gccaacttga gtctgctctg     60

cagctttagg cccgacttgg aaggcccatg ggctgcagat gaggaaactg aggtccagac    120

agccgaagag tggtagtgtc caggacacac aactgggccg gcggcggcgg ctgccccgag    180

ggacgcggcc ctaggcggtg gcgatgggga ccgcccggat cgcacccggc ctggcgctcc    240

tgctctgctg ccccgtgctc agctccgcgt acgcgctggt ggatgcagat gacgtcatga    300

ctaaagagga acagatcttc ctgctgcacc gtgctcaggc ccagtgcgaa aaacggctca    360

aggaggtcct gcagaggcca gccagcataa tggaatcaga caagggatgg acatctgcgt    420

ccacatcagg gaagcccagg aaagataagg catctgggaa gctctaccct gagtctgagg    480

aggacaagga ggcacccact ggcagcaggt accgagggcg cccctgtctg ccggaatggg    540

accacatcct gtgctggccg ctgggggcac caggtgaggt ggtggctgtg ccctgtccgg    600

actacattta tgacttcaat cacaaaggcc atgcctaccg acgctgtgac cgcaatggca    660

gctgggagct ggtgcctggg cacaacagga cgtgggccaa ctacagcgag tgtgtcaaat    720

ttctcaccaa tgagactcgt gaacgggagg tgtttgaccg cctgggcatg atttacaccg    780

tgggctactc cgtgtccctg gcgtccctca ccgtagctgt gctcatcctg gcctacttta    840

ggcggctgca ctgcacgcgc aactacatcc acatgcacct gttcctgtcc ttcatgctgc    900

gcgccgtgag catcttcgtc aaggacgctg tgctctactc tggcgccacg cttgatgagg    960

ctgagcgcct caccgaggag gagctgcgcg ccatcgccca ggcgcccccg ccgcctgcca   1020

ccgccgctgc cggctacgcg ggctgcaggg tggctgtgac cttcttcctt tacttcctgg   1080

ccaccaacta ctactggatt ctggtggagg ggctgtacct gcacagcctc atcttcatgg   1140

ccttcttctc agagaagaag tacctgtggg gcttcacagt cttcggctgg ggtctgcccg   1200

ctgtcttcgt ggctgtgtgg gtcagtgtca gagctaccct ggccaacacc gggtgctggg   1260

acttgagctc cgggaacaaa aagtggatca tccaggtgcc catcctggcc tccattgtgc   1320

tcaacttcat cctcttcatc aatatcgtcc gggtgctcgc caccaagctg cgggagacca   1380

acgccggccg gtgtgacaca cggcagcagt accggaagct gctcaaatcc acgctggtgc   1440

tcatgcccct ctttggcgtc cactacattg tcttcatggc cacaccatac accgaggtct   1500

cagggacgct ctggcaagtc cagatgcact atgagatgct cttcaactcc ttccagggat   1560

tttttgtcgc aatcatatac tgtttctgca atggcgaggt acaagctgag atcaagaaat   1620

cttggagccg ctggacactg gcactggact tcaagcgaaa ggcacgcagc gggagcagca   1680

gctatagcta cggccccatg gtgtcccaca caagtgtgac caatgtcggc ccccgtgtgg   1740

gactcggcct gcccctcagc ccccgcctac tgcccactgc caccaccaac ggccaccctc   1800

agctgcctgg ccatgccaag ccagggaccc cagccctgga gaccctcgag accacaccac   1860

ctgccatggc tgctcccaag gacgatgggt tcctcaacgg ctcctgctca ggcctggacg   1920

aggaggcctc tgggcctgag cggccacctg ccctgctaca ggaagagtgg gagacagtca   1980

tgtgaccagg cgctgggggc tggacctgct gacatagtgg atggacagat ggaccaaaag   2040

atgggtggtt gaatgatttc ccactcaggg ctggggccaa gaggaaaaac agggaaaaaa   2100

agaaaaaaaa aagaaaaagg aaaaggaaaa aaaaaaaaaa aaaa                    2144


<210>  774
<211>  593
<212>  PRT
<213>  Homosapiens

<400>  774

Met Gly Thr Ala Arg Ile Ala Pro Gly Leu Ala Leu Leu Leu Cys Cys 
1               5                   10                  15      


Pro Val Leu Ser Ser Ala Tyr Ala Leu Val Asp Ala Asp Asp Val Met 
            20                  25                  30          


Thr Lys Glu Glu Gln Ile Phe Leu Leu His Arg Ala Gln Ala Gln Cys 
        35                  40                  45              


Glu Lys Arg Leu Lys Glu Val Leu Gln Arg Pro Ala Ser Ile Met Glu 
    50                  55                  60                  


Ser Asp Lys Gly Trp Thr Ser Ala Ser Thr Ser Gly Lys Pro Arg Lys 
65                  70                  75                  80  


Asp Lys Ala Ser Gly Lys Leu Tyr Pro Glu Ser Glu Glu Asp Lys Glu 
                85                  90                  95      


Ala Pro Thr Gly Ser Arg Tyr Arg Gly Arg Pro Cys Leu Pro Glu Trp 
            100                 105                 110         


Asp His Ile Leu Cys Trp Pro Leu Gly Ala Pro Gly Glu Val Val Ala 
        115                 120                 125             


Val Pro Cys Pro Asp Tyr Ile Tyr Asp Phe Asn His Lys Gly His Ala 
    130                 135                 140                 


Tyr Arg Arg Cys Asp Arg Asn Gly Ser Trp Glu Leu Val Pro Gly His 
145                 150                 155                 160 


Asn Arg Thr Trp Ala Asn Tyr Ser Glu Cys Val Lys Phe Leu Thr Asn 
                165                 170                 175     


Glu Thr Arg Glu Arg Glu Val Phe Asp Arg Leu Gly Met Ile Tyr Thr 
            180                 185                 190         


Val Gly Tyr Ser Val Ser Leu Ala Ser Leu Thr Val Ala Val Leu Ile 
        195                 200                 205             


Leu Ala Tyr Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Met 
    210                 215                 220                 


His Leu Phe Leu Ser Phe Met Leu Arg Ala Val Ser Ile Phe Val Lys 
225                 230                 235                 240 


Asp Ala Val Leu Tyr Ser Gly Ala Thr Leu Asp Glu Ala Glu Arg Leu 
                245                 250                 255     


Thr Glu Glu Glu Leu Arg Ala Ile Ala Gln Ala Pro Pro Pro Pro Ala 
            260                 265                 270         


Thr Ala Ala Ala Gly Tyr Ala Gly Cys Arg Val Ala Val Thr Phe Phe 
        275                 280                 285             


Leu Tyr Phe Leu Ala Thr Asn Tyr Tyr Trp Ile Leu Val Glu Gly Leu 
    290                 295                 300                 


Tyr Leu His Ser Leu Ile Phe Met Ala Phe Phe Ser Glu Lys Lys Tyr 
305                 310                 315                 320 


Leu Trp Gly Phe Thr Val Phe Gly Trp Gly Leu Pro Ala Val Phe Val 
                325                 330                 335     


Ala Val Trp Val Ser Val Arg Ala Thr Leu Ala Asn Thr Gly Cys Trp 
            340                 345                 350         


Asp Leu Ser Ser Gly Asn Lys Lys Trp Ile Ile Gln Val Pro Ile Leu 
        355                 360                 365             


Ala Ser Ile Val Leu Asn Phe Ile Leu Phe Ile Asn Ile Val Arg Val 
    370                 375                 380                 


Leu Ala Thr Lys Leu Arg Glu Thr Asn Ala Gly Arg Cys Asp Thr Arg 
385                 390                 395                 400 


Gln Gln Tyr Arg Lys Leu Leu Lys Ser Thr Leu Val Leu Met Pro Leu 
                405                 410                 415     


Phe Gly Val His Tyr Ile Val Phe Met Ala Thr Pro Tyr Thr Glu Val 
            420                 425                 430         


Ser Gly Thr Leu Trp Gln Val Gln Met His Tyr Glu Met Leu Phe Asn 
        435                 440                 445             


Ser Phe Gln Gly Phe Phe Val Ala Ile Ile Tyr Cys Phe Cys Asn Gly 
    450                 455                 460                 


Glu Val Gln Ala Glu Ile Lys Lys Ser Trp Ser Arg Trp Thr Leu Ala 
465                 470                 475                 480 


Leu Asp Phe Lys Arg Lys Ala Arg Ser Gly Ser Ser Ser Tyr Ser Tyr 
                485                 490                 495     


Gly Pro Met Val Ser His Thr Ser Val Thr Asn Val Gly Pro Arg Val 
            500                 505                 510         


Gly Leu Gly Leu Pro Leu Ser Pro Arg Leu Leu Pro Thr Ala Thr Thr 
        515                 520                 525             


Asn Gly His Pro Gln Leu Pro Gly His Ala Lys Pro Gly Thr Pro Ala 
    530                 535                 540                 


Leu Glu Thr Leu Glu Thr Thr Pro Pro Ala Met Ala Ala Pro Lys Asp 
545                 550                 555                 560 


Asp Gly Phe Leu Asn Gly Ser Cys Ser Gly Leu Asp Glu Glu Ala Ser 
                565                 570                 575     


Gly Pro Glu Arg Pro Pro Ala Leu Leu Gln Glu Glu Trp Glu Thr Val 
            580                 585                 590         


Met 
    


<210>  775
<211>  874
<212>  DNA
<213>  Homosapiens

<400>  775
ggggtacgcg ggcaagatgg aggcgactac ggctggtgtg ggccggctag aggaagaggc     60

gttgcggcga aaggaacggc tgaaggccct acgggagaaa accgggcgca aggacaagga    120

agatggggag ccaaagacca agcatctcag agaagaggag gaagaaggcg agaagcacag    180

ggaacttagg ctgcggaact atgtcccgga ggatgaggac ctgaagaaga ggagggtgcc    240

ccaggccaaa ccggttgcag tggaggagaa ggtgaaggag cagctggagg ccgccaagcc    300

cgagcccgtc atcgaggagg tggacctggc caacctcgct cctcggaagc ctgactggga    360

cctcaagaga gatgtggcca agaagctgga gaaactaaaa aagcggactc agagggctat    420

tgccgagctg atccgtgaaa ggctgaaagg ccaggaagac agcctagcct ctgcagtgga    480

tgctgccacc gaacaaaaga cctgtgactc cgactgaggc atgccctgcc ccaccactcg    540

cccatcaggc ctgtcctgca ggggatggtc ttgggcaggg atgggggcta ggcttgccat    600

cacctccagt ttggcttctg agcagagact ccctgcccat caagtctgaa acccccatgg    660

atgaggtcag ctccttgtct gctgggtggc ccctgccatt ctgaatggag gcagaaccag    720

caacaactct gggcgtgcct gtgtctgcac atgtggatgt acatatgtct gtatatatgt    780

atatattttg aactttctaa aaaaaaatct ggaaatagaa acaagtaaac ccctgtgtgt    840

ggcgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                874


<210>  776
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  776

Met Glu Ala Thr Thr Ala Gly Val Gly Arg Leu Glu Glu Glu Ala Leu 
1               5                   10                  15      


Arg Arg Lys Glu Arg Leu Lys Ala Leu Arg Glu Lys Thr Gly Arg Lys 
            20                  25                  30          


Asp Lys Glu Asp Gly Glu Pro Lys Thr Lys His Leu Arg Glu Glu Glu 
        35                  40                  45              


Glu Glu Gly Glu Lys His Arg Glu Leu Arg Leu Arg Asn Tyr Val Pro 
    50                  55                  60                  


Glu Asp Glu Asp Leu Lys Lys Arg Arg Val Pro Gln Ala Lys Pro Val 
65                  70                  75                  80  


Ala Val Glu Glu Lys Val Lys Glu Gln Leu Glu Ala Ala Lys Pro Glu 
                85                  90                  95      


Pro Val Ile Glu Glu Val Asp Leu Ala Asn Leu Ala Pro Arg Lys Pro 
            100                 105                 110         


Asp Trp Asp Leu Lys Arg Asp Val Ala Lys Lys Leu Glu Lys Leu Lys 
        115                 120                 125             


Lys Arg Thr Gln Arg Ala Ile Ala Glu Leu Ile Arg Glu Arg Leu Lys 
    130                 135                 140                 


Gly Gln Glu Asp Ser Leu Ala Ser Ala Val Asp Ala Ala Thr Glu Gln 
145                 150                 155                 160 


Lys Thr Cys Asp Ser Asp 
                165     


<210>  777
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  777
atgcagtcag gcgagcagcg tcctgggcgg attcagaccc tggggaagtc tggaattcct     60

caccccgacc ctcgtcccgg aggctcaggc tggcccttcc aatggcactg gtggcgcgca    120

gcagggccgg agccgggccg ggccatggcc gcctcggagc ggctgtacga gttgtggctg    180

ctctactacg cgcagaagga cctgggttac ctgcagcagt ggctgaaggc ctttgtaggt    240

gccttcaaga agagcatctc actgtcctct ctggagccac gaaggccaga ggaggcaggt    300

gcagaggtcc cgctgctacc actggatgag ctgcatgtgc tggccgaaca gctgcaccag    360

gctgacctgg agcaagccct cctgctgctc aagctcttca tcattctctg caggaacctg    420

gagaacatag aggcaggccg gggccaagtg ctagtgcccc gagtgctggc actgttgacc    480

aagttggtgg cggagctgaa aggatgccca ccaccccagg gccgaggcac gcagttggag    540

aatgtggccc tacatgctct gcttctctgc gagggcctct ttgaccctta ccaaacctgg    600

cggcgccagc gcagtgggga agtcatcagc tccaaggaga agagcaaata caagttccct    660

cctgctgctt tgccccagga attcagcgcc ttcttccaag agagcctaca gaatgcagac    720

cacttgcctc ccatactgct gttacgtctc atccacctct tctgcgccgt cctcgctgga    780

ggaaaggaga acgggcagat ggctgtaagt gatggctctg tgaagggcct gctgagtgtg    840

gtgcggggct ggagccgtgg gccagccccg gacccgtgcc tagtgccact ggctctagag    900

gcactggtag gtgcagtcca tgtcttgcat gccagccgcg cacctcctcg tggcccagag    960

cttcgtgccc tgcttgagag ctacttccat gtccttaatg ctgactggcc agctggtctg   1020

agctcaggcc ccgaagaggc ccttgtcacc ctccgggtca gcatgctcga cgccatcccc   1080

atgatgctgg catgtgaaga ccggccagtg ctgcaagcca ccttcctcag caacaattgc   1140

tttgaacacc tcactcggct cattcagaac agcaagctgt acctgcagtc ccgggcgccc   1200

cccgaggggg acagtgacct ggctacccgg ttactgactg agcccgatgt ccaaaaggtc   1260

ctggaccaag acacagacgc cattgcagtc catgtagtca gagtgctgac ctgcatcatg   1320

agtgactccc cctcggccaa ggaggtgttt aaggagcgca tcggctaccc tcacctgcag   1380

gaggttctgc agagccatgg tccccccacc catcggctgt tgcaagagct gctcaacatg   1440

gctgtggagg gtgaccacag catgtgccca cctccaccaa tccgcaacga gcagccggta   1500

ctggtgctgg cgcagtggct gccgtcattg cccaccgctg agctgcggct cttcctagcg   1560

caacgcctca ggtggctctg tgacagctgc cctgccagcc gtgccacctg tgtgcaggca   1620

ggcctggtgg gctgcctgtt ggagacactc agcacagggc tagccctgga ggcccgctgc   1680

caagagcagc tgctggcact gctacaagca ctgggccgtg tatcaataag gcccatggag   1740

ctgcgtcacc tgctgcgccc ccggccagga ttggactcgg aaccaggcgg agctgaggct   1800

ggaaaggccc gacacgcagg tgctgtcatc cgcacattat caggcatggc caggcaccag   1860

ggtcctgcac gtgctctgcg ctactttgac ctcacgccca gcatggcggg catcatggta   1920

ccccctgtac agcgatggcc agggcctggc ttcacctttc atgcctggct ctgtctgcac   1980

cctatggata cagcacctac ccctgccccc acccgaccac tccagcgaaa gcagctgtac   2040

agcttcttta ccagcagcgg ctcagggttt gaggccttct tcacggcggc cgggaccctg   2100

gtggtggctg tgtgcacacg gaaggagtat ttgaccatga gtttgcccga agtgtccttt   2160

gccgactctg cctggcactg cgtggctatc gtccatgtgc ctgggcgccg gcccttcagc   2220

cagaacctgg tccatgtcta caaagacggc catctggtca agacagcacc ccttcgctgc   2280

ccctccctca gtgagccttt ctcctcctgc tgtatcggct ccgctggata ccgcacaacg   2340

accaccacca cagggctgcc cacaccacca gtccccgcca ccctggccta cactcacccc   2400

gccctcaccc gctcccagtc agtcccagcc tccacagggc ttggctgggg gtccgggctg   2460

gtggcccccc tgcaggaggg cagcatcgac tctaccctcg caggcaccca ggacactcgg   2520

tggggcagcc ccacatccct ggagggtgag ctgggggctg tggccatctt tcacgaagcc   2580

ctgcaggcga cggctctgag gaccctgtgc accctggggc ccaatgagac ggcacccttc   2640

aagcctgagg gggagctgca tgagctcagc accaggctgc tcctccatta ctcacctcag   2700

gcttgtaaga acaacatctg cctggacctg tcccccagtc atgggcttga tgggcgcctg   2760

acgggccaca gagtggagac ctgggatgtg aaggatgtgg tgaactgcgt tgggggtatg   2820

ggtgccctgc tgcccctgct ggagcgagta gctgcacagc ccaaagaggc tgaagcaggt   2880

ccagctgaaa cgcatgacct cgtgggtcct gaactgacct ctggtcacaa cacccagggc   2940

ctggttctcc cattgggtaa atcttcagag gaacggatgg agaggaacgc agtggctgct   3000

tttctgctga tgctgcggaa cttccttcag ggtcacatgg tgaaccaaga gagcctggtg   3060

cagtgccagg ggcctgccat catcggggcc ctcctgcgaa aggtcccaag ctgggccatg   3120

gacatgaacg tgctcatgtc cgcccagctg ctgatggagc aggtggcagc tgagggcagc   3180

gggcccctcc tgtacctact ctaccagcat ttgctcttca actttcacct ctggaccctc   3240

agtgacttcg ccgtgcgcct cggtcacatc cagtacatgt ccagcatagt tcgggagcac   3300

agacagaagc tgcggaagaa gtacggcgtc cagtttatct tggatgctct gcgcacccac   3360

tacagcccgc agcgggagcg ccccctggct gctgacgacc tacgcaccgt gcagacctcc   3420

ctcctgggcc tggcgaggga gttcctggtg cggagtctct cagcagatga cgtgcaggtc   3480

acgcagacca tgctgagctt tttggcggcc acaggcgatg acggtcaggc ggtgggtgcg   3540

ctggacctgc tgctggccct gctgcacggt tccctggtgc aggagtcctt ggctgtcttt   3600

ctgttggagc cagggaacct cgaagtgcta ctggccctgc tagtgcggcc agggtcactg   3660

cccctgctgc ccgatcgagt ctgcaagatc ctgcgcagac tgcagcagaa tgagcggcta   3720

cctgagcgga gccgccagcg cctccggctg cgggagtgtg gtctccaggg tctggttgcc   3780

tgcttgcctg aggggactgt ttccccccag ctctgccagg gcctctacaa gctgttcctg   3840

ggggcagatt gcctgaacct ctcagatctg ctggctgtgg tacagctgtc cctccaggct   3900

gacctcagcg ttcgcctaga catctgtcgc cagcttttcc acctcatcta cggacagcca   3960

gatgtagtgc ggcttctggc ccgacaggct ggctggcaag atgtgctgac ccggctatat   4020

gtcctggagg ctgccacagc cggcagcccc cctccgtctt ccccagagtc acctacctcc   4080

cccaagccag ccccacccaa gccacccact gagtcacctg ctgagccttc agatgtcttc   4140

ctgccctcag aggccccctg ccctgaccct gatggctttt accatgctct ctccccattc   4200

tgcacgccct ttgacctggg cctggaacgg tctagtgtag gatcaggcaa cactgctggt   4260

ggtggcggca gcagtgggac tcttactcca gccagccagc ccggcactcc ttcgccactg   4320

gatgggccgc ggccctttcc tgctgctcct ggccgccaca gctccagtct ctccaatgtg   4380

ctggaggacg gcagcctccc ggagcccacc attagcgggg atgatacctc gaacaccagc   4440

aacccacagc aaacctctga ggaagagttg tgcaatctgc tcaccaacgt gctgttctcg   4500

gtgacgtggc gtggcgtgga aggcagcgat gaggctgcct ggcgggagcg tggccaggtt   4560

ttctcagtgc tcacccagct gggggcctca gccacacttg tgcgcccacc agactgcatc   4620

aagcgcagcc tcctggagat gatgctggag tcagccctga ccgacatcaa agaggccccc   4680

gtgggggtcc tggccagcct cacccagcaa gcgctttggc tgctgcgtct gctgcaggac   4740

ttcctgtgtg ctgaaggcca tggtaaccag gaactgtgga gtgagaagct ctttgaaggt   4800

gtatgcagcc tacttgatcg cctgggagcc tggccccacc tggccaacgg cacagctgat   4860

ctccgtgaga tggcgcagat tggcctacgg cttgtacttg gctacatcct gctggaagac   4920

ccacagctgc atgcccaggc ctacgtgaga ttgcacatgc tgctacagac tgcagtgcca   4980

gcccgccgcg aggaggcctg ctatgtgctc tccaagctgg aggctgcact ggggcgggtg   5040

ctgaacacct cttccttgga gtcagccact gatgaggcag ggtccccact tgcagctgca   5100

gcagctgcag cagctgcaga gcgctgctcc tggctggtgc cactggtgcg cacgctgcta   5160

gaccgtgcct atgagccgct ggggctgcag tggggactgc cctccctgcc acccaccaat   5220

ggcagcccca ccttctttga agacttccag gctttttgtg ccacacccga atggcgccac   5280

ttcatcgaca aacaggtaca gccaaccatg tcccagttcg aaatggacac gtatgctaag   5340

agccacgacc ttatgtcagg tttctggaat gcctgctatg acatgcttat gagcagtggg   5400

cagcggcgcc agtgggagcg cgcccagagt cgtcgggcct tccaggagct ggtgctggaa   5460

cctgcgcaga ggcgggcgcg cctggagggg ctacgctaca cggcagtgct gaagcagcag   5520

gcaacgcagc actccatggc cctgctgcac tggggggcgc tgtggcgcca gctcgccagc   5580

ccatgtgggg cctgggcgct gagggacact cccatccccc gctggaaact gtccagcgcc   5640

gagacatatt cacgcatgcg tctgaagctg gtgcccaacc atcacttcga ccctcacctg   5700

gaagccagcg ctctccgaga caatctgggt gaggttcccc tgacacccac cgaggaggcc   5760

tcactgcctc tggcagtgac caaagaggcc aaagtgagca ccccacccga gttgctgcag   5820

gaggaccagc tcggcgagga cgagctggct gagctggaga ccccgatgga ggcagcagaa   5880

ctggatgagc agcgtgagaa gctggtgctg tcggccgagt gccagctggt gacggtagtg   5940

gccgtggtcc cagggctgct ggaggtcacc acacagaatg tatacttcta cgatggcagc   6000

actgagcgcg tggaaaccga ggagggcatc ggctatgatt tccggcgccc actggcccag   6060

ctgcgtgagg tccacctgcg gcgtttcaac ctgcgccgtt cagcacttga gctcttcttt   6120

atcgatcagg ccaactactt cctcaacttc ccatgcaagg tgggcacgac cccagtctca   6180

tctcctagcc agactcccag accccagcct ggccccatcc caccccatac ccaggtacgg   6240

aaccaggtgt actcgtggct cctgcgccta cggcccccct ctcaaggcta cctaagcagc   6300

cgctcccccc aggagatgct gcgtgcctca ggccttaccc agaaatgggt acagcgtgag   6360

atatccaact tcgagtactt gatgcaactc aacaccattg cggggcggac ctacaatgac   6420

ctgtctcagt accctgtgtt cccctgggtc ctgcaggact acgtgtcccc aaccctggac   6480

ctcagcaacc cagccgtctt ccgggacctg tctaagccca tcggtgtggt gaaccccaag   6540

catgcccagc tcgtgaggga gaagtatgaa agctttgagg acccagcagg gaccattgac   6600

aagttccact atggcaccca ctactccaat gcagcaggcg tgatgcacta cctcatccgc   6660

gtggagccct tcacctccct gcacgtccag ctgcaaagtg gccgctttga ctgctccgac   6720

cggcagttcc actcggtggc ggcagcctgg caggcacgcc tggagagccc tgccgatgtg   6780

aaggagctca tcccggaatt cttctacttt cctgacttcc tggagaacca gaacggtttt   6840

gacctgggct gtctccagct gaccaacgag aaggtaggcg atgtggtgct acccccgtgg   6900

gccagctctc ctgaggactt catccagcag caccgccagg ctctggagtc ggagtatgtg   6960

tctgcacacc tacacgagtg gatcgacctc atctttggct acaagcagcg ggggccagcc   7020

gccgaggagg ccctcaatgt cttctattac tgcacctatg agggggctgt agacctggac   7080

catgtgacag atgagcggga acggaaggct ctggagggca ttatcagcaa ctttgggcag   7140

actccctgtc agctgctgaa ggagccacat ccaactcggc tctcagctga ggaagcagcc   7200

catcgccttg cacgcctgga cactaactca cctagcatct tccagcacct ggacgaactc   7260

aaggcattct tcgcagaggt tgtcagtgat ggtgtacccc tggtgctagc cctggtcccc   7320

caccggcagc cccactcctt catcacccag ggttccccag acctgttggt gactgtgagt   7380

gccagtgggc tgctgggcac ccacagctgg ttgccctatg accgcaacat aagcaactac   7440

ttcagcttca gcaaagaccc caccatgggc agccacaaga cgcagcgact gctgagtggc   7500

ccgtgggtgc caggcagtgg tgtgagtgga caagcactgg cagtggcccc ggatggaaag   7560

ctgctattca gcggtggcca ctgggatggc agcctgcggg tgactgcact accccgtggc   7620

aagctgttga gccagctcag ctgccacctt gatgtagtaa cctgccttgc actggacacc   7680

tgtggcatct acctcatctc aggctcccgg gacaccacgt gcatggtgtg gcggctcctg   7740

catcagggtg gtctgtcagt aggcctggca ccaaagcctg tgcaggtcct gtatgggcat   7800

ggggctgcag tgagctgtgt ggccatcagc actgaacttg acatggctgt gtctggatct   7860

gaggatggaa ctgtgatcat acacactgta cgccgcggac agtttgtagc ggcactacgg   7920

cctctgggtg ccacattccc tggacctatt ttccacctgg cattggggtc cgaaggccag   7980

attgtggtac agagctcagc gtgggaacgt cctggggccc aggtcaccta ctccttgcac   8040

ctgtattcag tcaatgggaa gttgcgggct tcactgcccc tggcagagca gcctacagcc   8100

ctgacggtga cagaggactt tgtgttgctg ggcaccgccc agtgcgccct gcacatcctc   8160

caactaaaca cactgctccc ggccgcgcct cc                                 8192


<210>  778
<211>  2802
<212>  PRT
<213>  Homosapiens

<400>  778

Met Gln Ser Gly Glu Gln Arg Pro Gly Arg Ile Gln Thr Leu Gly Lys 
1               5                   10                  15      


Ser Gly Ile Pro His Pro Asp Pro Arg Pro Gly Gly Ser Gly Trp Pro 
            20                  25                  30          


Phe Gln Trp His Trp Trp Arg Ala Ala Gly Pro Glu Pro Gly Arg Ala 
        35                  40                  45              


Met Ala Ala Ser Glu Arg Leu Tyr Glu Leu Trp Leu Leu Tyr Tyr Ala 
    50                  55                  60                  


Gln Lys Asp Leu Gly Tyr Leu Gln Gln Trp Leu Lys Ala Phe Val Gly 
65                  70                  75                  80  


Ala Phe Lys Lys Ser Ile Ser Leu Ser Ser Leu Glu Pro Arg Arg Pro 
                85                  90                  95      


Glu Glu Ala Gly Ala Glu Val Pro Leu Leu Pro Leu Asp Glu Leu His 
            100                 105                 110         


Val Leu Ala Glu Gln Leu His Gln Ala Asp Leu Glu Gln Ala Leu Leu 
        115                 120                 125             


Leu Leu Lys Leu Phe Ile Ile Leu Cys Arg Asn Leu Glu Asn Ile Glu 
    130                 135                 140                 


Ala Gly Arg Gly Gln Val Leu Val Pro Arg Val Leu Ala Leu Leu Thr 
145                 150                 155                 160 


Lys Leu Val Ala Glu Leu Lys Gly Cys Pro Pro Pro Gln Gly Arg Gly 
                165                 170                 175     


Thr Gln Leu Glu Asn Val Ala Leu His Ala Leu Leu Leu Cys Glu Gly 
            180                 185                 190         


Leu Phe Asp Pro Tyr Gln Thr Trp Arg Arg Gln Arg Ser Gly Glu Val 
        195                 200                 205             


Ile Ser Ser Lys Glu Lys Ser Lys Tyr Lys Phe Pro Pro Ala Ala Leu 
    210                 215                 220                 


Pro Gln Glu Phe Ser Ala Phe Phe Gln Glu Ser Leu Gln Asn Ala Asp 
225                 230                 235                 240 


His Leu Pro Pro Ile Leu Leu Leu Arg Leu Ile His Leu Phe Cys Ala 
                245                 250                 255     


Val Leu Ala Gly Gly Lys Glu Asn Gly Gln Met Ala Val Ser Asp Gly 
            260                 265                 270         


Ser Val Lys Gly Leu Leu Ser Val Val Arg Gly Trp Ser Arg Gly Pro 
        275                 280                 285             


Ala Pro Asp Pro Cys Leu Val Pro Leu Ala Leu Glu Ala Leu Val Gly 
    290                 295                 300                 


Ala Val His Val Leu His Ala Ser Arg Ala Pro Pro Arg Gly Pro Glu 
305                 310                 315                 320 


Leu Arg Ala Leu Leu Glu Ser Tyr Phe His Val Leu Asn Ala Asp Trp 
                325                 330                 335     


Pro Ala Gly Leu Ser Ser Gly Pro Glu Glu Ala Leu Val Thr Leu Arg 
            340                 345                 350         


Val Ser Met Leu Asp Ala Ile Pro Met Met Leu Ala Cys Glu Asp Arg 
        355                 360                 365             


Pro Val Leu Gln Ala Thr Phe Leu Ser Asn Asn Cys Phe Glu His Leu 
    370                 375                 380                 


Thr Arg Leu Ile Gln Asn Ser Lys Leu Tyr Leu Gln Ser Arg Ala Pro 
385                 390                 395                 400 


Pro Glu Gly Asp Ser Asp Leu Ala Thr Arg Leu Leu Thr Glu Pro Asp 
                405                 410                 415     


Val Gln Lys Val Leu Asp Gln Asp Thr Asp Ala Ile Ala Val His Val 
            420                 425                 430         


Val Arg Val Leu Thr Cys Ile Met Ser Asp Ser Pro Ser Ala Lys Glu 
        435                 440                 445             


Val Phe Lys Glu Arg Ile Gly Tyr Pro His Leu Gln Glu Val Leu Gln 
    450                 455                 460                 


Ser His Gly Pro Pro Thr His Arg Leu Leu Gln Glu Leu Leu Asn Met 
465                 470                 475                 480 


Ala Val Glu Gly Asp His Ser Met Cys Pro Pro Pro Pro Ile Arg Asn 
                485                 490                 495     


Glu Gln Pro Val Leu Val Leu Ala Gln Trp Leu Pro Ser Leu Pro Thr 
            500                 505                 510         


Ala Glu Leu Arg Leu Phe Leu Ala Gln Arg Leu Arg Trp Leu Cys Asp 
        515                 520                 525             


Ser Cys Pro Ala Ser Arg Ala Thr Cys Val Gln Ala Gly Leu Val Gly 
    530                 535                 540                 


Cys Leu Leu Glu Thr Leu Ser Thr Gly Leu Ala Leu Glu Ala Arg Cys 
545                 550                 555                 560 


Gln Glu Gln Leu Leu Ala Leu Leu Gln Ala Leu Gly Arg Val Ser Ile 
                565                 570                 575     


Arg Pro Met Glu Leu Arg His Leu Leu Arg Pro Arg Pro Gly Leu Asp 
            580                 585                 590         


Ser Glu Pro Gly Gly Ala Glu Ala Gly Lys Ala Arg His Ala Gly Ala 
        595                 600                 605             


Val Ile Arg Thr Leu Ser Gly Met Ala Arg His Gln Gly Pro Ala Arg 
    610                 615                 620                 


Ala Leu Arg Tyr Phe Asp Leu Thr Pro Ser Met Ala Gly Ile Met Val 
625                 630                 635                 640 


Pro Pro Val Gln Arg Trp Pro Gly Pro Gly Phe Thr Phe His Ala Trp 
                645                 650                 655     


Leu Cys Leu His Pro Met Asp Thr Ala Pro Thr Pro Ala Pro Thr Arg 
            660                 665                 670         


Pro Leu Gln Arg Lys Gln Leu Tyr Ser Phe Phe Thr Ser Ser Gly Ser 
        675                 680                 685             


Gly Phe Glu Ala Phe Phe Thr Ala Ala Gly Thr Leu Val Val Ala Val 
    690                 695                 700                 


Cys Thr Arg Lys Glu Tyr Leu Thr Met Ser Leu Pro Glu Val Ser Phe 
705                 710                 715                 720 


Ala Asp Ser Ala Trp His Cys Val Ala Ile Val His Val Pro Gly Arg 
                725                 730                 735     


Arg Pro Phe Ser Gln Asn Leu Val His Val Tyr Lys Asp Gly His Leu 
            740                 745                 750         


Val Lys Thr Ala Pro Leu Arg Cys Pro Ser Leu Ser Glu Pro Phe Ser 
        755                 760                 765             


Ser Cys Cys Ile Gly Ser Ala Gly Tyr Arg Thr Thr Thr Thr Thr Thr 
    770                 775                 780                 


Gly Leu Pro Thr Pro Pro Val Pro Ala Thr Leu Ala Tyr Thr His Pro 
785                 790                 795                 800 


Ala Leu Thr Arg Ser Gln Ser Val Pro Ala Ser Thr Gly Leu Gly Trp 
                805                 810                 815     


Gly Ser Gly Leu Val Ala Pro Leu Gln Glu Gly Ser Ile Asp Ser Thr 
            820                 825                 830         


Leu Ala Gly Thr Gln Asp Thr Arg Trp Gly Ser Pro Thr Ser Leu Glu 
        835                 840                 845             


Gly Glu Leu Gly Ala Val Ala Ile Phe His Glu Ala Leu Gln Ala Thr 
    850                 855                 860                 


Ala Leu Arg Thr Leu Cys Thr Leu Gly Pro Asn Glu Thr Ala Pro Phe 
865                 870                 875                 880 


Lys Pro Glu Gly Glu Leu His Glu Leu Ser Thr Arg Leu Leu Leu His 
                885                 890                 895     


Tyr Ser Pro Gln Ala Cys Lys Asn Asn Ile Cys Leu Asp Leu Ser Pro 
            900                 905                 910         


Ser His Gly Leu Asp Gly Arg Leu Thr Gly His Arg Val Glu Thr Trp 
        915                 920                 925             


Asp Val Lys Asp Val Val Asn Cys Val Gly Gly Met Gly Ala Leu Leu 
    930                 935                 940                 


Pro Leu Leu Glu Arg Val Ala Ala Gln Pro Lys Glu Ala Glu Ala Gly 
945                 950                 955                 960 


Pro Ala Glu Thr His Asp Leu Val Gly Pro Glu Leu Thr Ser Gly His 
                965                 970                 975     


Asn Thr Gln Gly Leu Val Leu Pro Leu Gly Lys Ser Ser Glu Glu Arg 
            980                 985                 990         


Met Glu Arg Asn Ala Val Ala Ala  Phe Leu Leu Met Leu  Arg Asn Phe 
        995                 1000                 1005             


Leu Gln  Gly His Met Val Asn  Gln Glu Ser Leu Val  Gln Cys Gln 
    1010                 1015                 1020             


Gly Pro  Ala Ile Ile Gly Ala  Leu Leu Arg Lys Val  Pro Ser Trp 
    1025                 1030                 1035             


Ala Met  Asp Met Asn Val Leu  Met Ser Ala Gln Leu  Leu Met Glu 
    1040                 1045                 1050             


Gln Val  Ala Ala Glu Gly Ser  Gly Pro Leu Leu Tyr  Leu Leu Tyr 
    1055                 1060                 1065             


Gln His  Leu Leu Phe Asn Phe  His Leu Trp Thr Leu  Ser Asp Phe 
    1070                 1075                 1080             


Ala Val  Arg Leu Gly His Ile  Gln Tyr Met Ser Ser  Ile Val Arg 
    1085                 1090                 1095             


Glu His  Arg Gln Lys Leu Arg  Lys Lys Tyr Gly Val  Gln Phe Ile 
    1100                 1105                 1110             


Leu Asp  Ala Leu Arg Thr His  Tyr Ser Pro Gln Arg  Glu Arg Pro 
    1115                 1120                 1125             


Leu Ala  Ala Asp Asp Leu Arg  Thr Val Gln Thr Ser  Leu Leu Gly 
    1130                 1135                 1140             


Leu Ala  Arg Glu Phe Leu Val  Arg Ser Leu Ser Ala  Asp Asp Val 
    1145                 1150                 1155             


Gln Val  Thr Gln Thr Met Leu  Ser Phe Leu Ala Ala  Thr Gly Asp 
    1160                 1165                 1170             


Asp Gly  Gln Ala Val Gly Ala  Leu Asp Leu Leu Leu  Ala Leu Leu 
    1175                 1180                 1185             


His Gly  Ser Leu Val Gln Glu  Ser Leu Ala Val Phe  Leu Leu Glu 
    1190                 1195                 1200             


Pro Gly  Asn Leu Glu Val Leu  Leu Ala Leu Leu Val  Arg Pro Gly 
    1205                 1210                 1215             


Ser Leu  Pro Leu Leu Pro Asp  Arg Val Cys Lys Ile  Leu Arg Arg 
    1220                 1225                 1230             


Leu Gln  Gln Asn Glu Arg Leu  Pro Glu Arg Ser Arg  Gln Arg Leu 
    1235                 1240                 1245             


Arg Leu  Arg Glu Cys Gly Leu  Gln Gly Leu Val Ala  Cys Leu Pro 
    1250                 1255                 1260             


Glu Gly  Thr Val Ser Pro Gln  Leu Cys Gln Gly Leu  Tyr Lys Leu 
    1265                 1270                 1275             


Phe Leu  Gly Ala Asp Cys Leu  Asn Leu Ser Asp Leu  Leu Ala Val 
    1280                 1285                 1290             


Val Gln  Leu Ser Leu Gln Ala  Asp Leu Ser Val Arg  Leu Asp Ile 
    1295                 1300                 1305             


Cys Arg  Gln Leu Phe His Leu  Ile Tyr Gly Gln Pro  Asp Val Val 
    1310                 1315                 1320             


Arg Leu  Leu Ala Arg Gln Ala  Gly Trp Gln Asp Val  Leu Thr Arg 
    1325                 1330                 1335             


Leu Tyr  Val Leu Glu Ala Ala  Thr Ala Gly Ser Pro  Pro Pro Ser 
    1340                 1345                 1350             


Ser Pro  Glu Ser Pro Thr Ser  Pro Lys Pro Ala Pro  Pro Lys Pro 
    1355                 1360                 1365             


Pro Thr  Glu Ser Pro Ala Glu  Pro Ser Asp Val Phe  Leu Pro Ser 
    1370                 1375                 1380             


Glu Ala  Pro Cys Pro Asp Pro  Asp Gly Phe Tyr His  Ala Leu Ser 
    1385                 1390                 1395             


Pro Phe  Cys Thr Pro Phe Asp  Leu Gly Leu Glu Arg  Ser Ser Val 
    1400                 1405                 1410             


Gly Ser  Gly Asn Thr Ala Gly  Gly Gly Gly Ser Ser  Gly Thr Leu 
    1415                 1420                 1425             


Thr Pro  Ala Ser Gln Pro Gly  Thr Pro Ser Pro Leu  Asp Gly Pro 
    1430                 1435                 1440             


Arg Pro  Phe Pro Ala Ala Pro  Gly Arg His Ser Ser  Ser Leu Ser 
    1445                 1450                 1455             


Asn Val  Leu Glu Asp Gly Ser  Leu Pro Glu Pro Thr  Ile Ser Gly 
    1460                 1465                 1470             


Asp Asp  Thr Ser Asn Thr Ser  Asn Pro Gln Gln Thr  Ser Glu Glu 
    1475                 1480                 1485             


Glu Leu  Cys Asn Leu Leu Thr  Asn Val Leu Phe Ser  Val Thr Trp 
    1490                 1495                 1500             


Arg Gly  Val Glu Gly Ser Asp  Glu Ala Ala Trp Arg  Glu Arg Gly 
    1505                 1510                 1515             


Gln Val  Phe Ser Val Leu Thr  Gln Leu Gly Ala Ser  Ala Thr Leu 
    1520                 1525                 1530             


Val Arg  Pro Pro Asp Cys Ile  Lys Arg Ser Leu Leu  Glu Met Met 
    1535                 1540                 1545             


Leu Glu  Ser Ala Leu Thr Asp  Ile Lys Glu Ala Pro  Val Gly Val 
    1550                 1555                 1560             


Leu Ala  Ser Leu Thr Gln Gln  Ala Leu Trp Leu Leu  Arg Leu Leu 
    1565                 1570                 1575             


Gln Asp  Phe Leu Cys Ala Glu  Gly His Gly Asn Gln  Glu Leu Trp 
    1580                 1585                 1590             


Ser Glu  Lys Leu Phe Glu Gly  Val Cys Ser Leu Leu  Asp Arg Leu 
    1595                 1600                 1605             


Gly Ala  Trp Pro His Leu Ala  Asn Gly Thr Ala Asp  Leu Arg Glu 
    1610                 1615                 1620             


Met Ala  Gln Ile Gly Leu Arg  Leu Val Leu Gly Tyr  Ile Leu Leu 
    1625                 1630                 1635             


Glu Asp  Pro Gln Leu His Ala  Gln Ala Tyr Val Arg  Leu His Met 
    1640                 1645                 1650             


Leu Leu  Gln Thr Ala Val Pro  Ala Arg Arg Glu Glu  Ala Cys Tyr 
    1655                 1660                 1665             


Val Leu  Ser Lys Leu Glu Ala  Ala Leu Gly Arg Val  Leu Asn Thr 
    1670                 1675                 1680             


Ser Ser  Leu Glu Ser Ala Thr  Asp Glu Ala Gly Ser  Pro Leu Ala 
    1685                 1690                 1695             


Ala Ala  Ala Ala Ala Ala Ala  Ala Glu Arg Cys Ser  Trp Leu Val 
    1700                 1705                 1710             


Pro Leu  Val Arg Thr Leu Leu  Asp Arg Ala Tyr Glu  Pro Leu Gly 
    1715                 1720                 1725             


Leu Gln  Trp Gly Leu Pro Ser  Leu Pro Pro Thr Asn  Gly Ser Pro 
    1730                 1735                 1740             


Thr Phe  Phe Glu Asp Phe Gln  Ala Phe Cys Ala Thr  Pro Glu Trp 
    1745                 1750                 1755             


Arg His  Phe Ile Asp Lys Gln  Val Gln Pro Thr Met  Ser Gln Phe 
    1760                 1765                 1770             


Glu Met  Asp Thr Tyr Ala Lys  Ser His Asp Leu Met  Ser Gly Phe 
    1775                 1780                 1785             


Trp Asn  Ala Cys Tyr Asp Met  Leu Met Ser Ser Gly  Gln Arg Arg 
    1790                 1795                 1800             


Gln Trp  Glu Arg Ala Gln Ser  Arg Arg Ala Phe Gln  Glu Leu Val 
    1805                 1810                 1815             


Leu Glu  Pro Ala Gln Arg Arg  Ala Arg Leu Glu Gly  Leu Arg Tyr 
    1820                 1825                 1830             


Thr Ala  Val Leu Lys Gln Gln  Ala Thr Gln His Ser  Met Ala Leu 
    1835                 1840                 1845             


Leu His  Trp Gly Ala Leu Trp  Arg Gln Leu Ala Ser  Pro Cys Gly 
    1850                 1855                 1860             


Ala Trp  Ala Leu Arg Asp Thr  Pro Ile Pro Arg Trp  Lys Leu Ser 
    1865                 1870                 1875             


Ser Ala  Glu Thr Tyr Ser Arg  Met Arg Leu Lys Leu  Val Pro Asn 
    1880                 1885                 1890             


His His  Phe Asp Pro His Leu  Glu Ala Ser Ala Leu  Arg Asp Asn 
    1895                 1900                 1905             


Leu Gly  Glu Val Pro Leu Thr  Pro Thr Glu Glu Ala  Ser Leu Pro 
    1910                 1915                 1920             


Leu Ala  Val Thr Lys Glu Ala  Lys Val Ser Thr Pro  Pro Glu Leu 
    1925                 1930                 1935             


Leu Gln  Glu Asp Gln Leu Gly  Glu Asp Glu Leu Ala  Glu Leu Glu 
    1940                 1945                 1950             


Thr Pro  Met Glu Ala Ala Glu  Leu Asp Glu Gln Arg  Glu Lys Leu 
    1955                 1960                 1965             


Val Leu  Ser Ala Glu Cys Gln  Leu Val Thr Val Val  Ala Val Val 
    1970                 1975                 1980             


Pro Gly  Leu Leu Glu Val Thr  Thr Gln Asn Val Tyr  Phe Tyr Asp 
    1985                 1990                 1995             


Gly Ser  Thr Glu Arg Val Glu  Thr Glu Glu Gly Ile  Gly Tyr Asp 
    2000                 2005                 2010             


Phe Arg  Arg Pro Leu Ala Gln  Leu Arg Glu Val His  Leu Arg Arg 
    2015                 2020                 2025             


Phe Asn  Leu Arg Arg Ser Ala  Leu Glu Leu Phe Phe  Ile Asp Gln 
    2030                 2035                 2040             


Ala Asn  Tyr Phe Leu Asn Phe  Pro Cys Lys Val Gly  Thr Thr Pro 
    2045                 2050                 2055             


Val Ser  Ser Pro Ser Gln Thr  Pro Arg Pro Gln Pro  Gly Pro Ile 
    2060                 2065                 2070             


Pro Pro  His Thr Gln Val Arg  Asn Gln Val Tyr Ser  Trp Leu Leu 
    2075                 2080                 2085             


Arg Leu  Arg Pro Pro Ser Gln  Gly Tyr Leu Ser Ser  Arg Ser Pro 
    2090                 2095                 2100             


Gln Glu  Met Leu Arg Ala Ser  Gly Leu Thr Gln Lys  Trp Val Gln 
    2105                 2110                 2115             


Arg Glu  Ile Ser Asn Phe Glu  Tyr Leu Met Gln Leu  Asn Thr Ile 
    2120                 2125                 2130             


Ala Gly  Arg Thr Tyr Asn Asp  Leu Ser Gln Tyr Pro  Val Phe Pro 
    2135                 2140                 2145             


Trp Val  Leu Gln Asp Tyr Val  Ser Pro Thr Leu Asp  Leu Ser Asn 
    2150                 2155                 2160             


Pro Ala  Val Phe Arg Asp Leu  Ser Lys Pro Ile Gly  Val Val Asn 
    2165                 2170                 2175             


Pro Lys  His Ala Gln Leu Val  Arg Glu Lys Tyr Glu  Ser Phe Glu 
    2180                 2185                 2190             


Asp Pro  Ala Gly Thr Ile Asp  Lys Phe His Tyr Gly  Thr His Tyr 
    2195                 2200                 2205             


Ser Asn  Ala Ala Gly Val Met  His Tyr Leu Ile Arg  Val Glu Pro 
    2210                 2215                 2220             


Phe Thr  Ser Leu His Val Gln  Leu Gln Ser Gly Arg  Phe Asp Cys 
    2225                 2230                 2235             


Ser Asp  Arg Gln Phe His Ser  Val Ala Ala Ala Trp  Gln Ala Arg 
    2240                 2245                 2250             


Leu Glu  Ser Pro Ala Asp Val  Lys Glu Leu Ile Pro  Glu Phe Phe 
    2255                 2260                 2265             


Tyr Phe  Pro Asp Phe Leu Glu  Asn Gln Asn Gly Phe  Asp Leu Gly 
    2270                 2275                 2280             


Cys Leu  Gln Leu Thr Asn Glu  Lys Val Gly Asp Val  Val Leu Pro 
    2285                 2290                 2295             


Pro Trp  Ala Ser Ser Pro Glu  Asp Phe Ile Gln Gln  His Arg Gln 
    2300                 2305                 2310             


Ala Leu  Glu Ser Glu Tyr Val  Ser Ala His Leu His  Glu Trp Ile 
    2315                 2320                 2325             


Asp Leu  Ile Phe Gly Tyr Lys  Gln Arg Gly Pro Ala  Ala Glu Glu 
    2330                 2335                 2340             


Ala Leu  Asn Val Phe Tyr Tyr  Cys Thr Tyr Glu Gly  Ala Val Asp 
    2345                 2350                 2355             


Leu Asp  His Val Thr Asp Glu  Arg Glu Arg Lys Ala  Leu Glu Gly 
    2360                 2365                 2370             


Ile Ile  Ser Asn Phe Gly Gln  Thr Pro Cys Gln Leu  Leu Lys Glu 
    2375                 2380                 2385             


Pro His  Pro Thr Arg Leu Ser  Ala Glu Glu Ala Ala  His Arg Leu 
    2390                 2395                 2400             


Ala Arg  Leu Asp Thr Asn Ser  Pro Ser Ile Phe Gln  His Leu Asp 
    2405                 2410                 2415             


Glu Leu  Lys Ala Phe Phe Ala  Glu Val Val Ser Asp  Gly Val Pro 
    2420                 2425                 2430             


Leu Val  Leu Ala Leu Val Pro  His Arg Gln Pro His  Ser Phe Ile 
    2435                 2440                 2445             


Thr Gln  Gly Ser Pro Asp Leu  Leu Val Thr Val Ser  Ala Ser Gly 
    2450                 2455                 2460             


Leu Leu  Gly Thr His Ser Trp  Leu Pro Tyr Asp Arg  Asn Ile Ser 
    2465                 2470                 2475             


Asn Tyr  Phe Ser Phe Ser Lys  Asp Pro Thr Met Gly  Ser His Lys 
    2480                 2485                 2490             


Thr Gln  Arg Leu Leu Ser Gly  Pro Trp Val Pro Gly  Ser Gly Val 
    2495                 2500                 2505             


Ser Gly  Gln Ala Leu Ala Val  Ala Pro Asp Gly Lys  Leu Leu Phe 
    2510                 2515                 2520             


Ser Gly  Gly His Trp Asp Gly  Ser Leu Arg Val Thr  Ala Leu Pro 
    2525                 2530                 2535             


Arg Gly  Lys Leu Leu Ser Gln  Leu Ser Cys His Leu  Asp Val Val 
    2540                 2545                 2550             


Thr Cys  Leu Ala Leu Asp Thr  Cys Gly Ile Tyr Leu  Ile Ser Gly 
    2555                 2560                 2565             


Ser Arg  Asp Thr Thr Cys Met  Val Trp Arg Leu Leu  His Gln Gly 
    2570                 2575                 2580             


Gly Leu  Ser Val Gly Leu Ala  Pro Lys Pro Val Gln  Val Leu Tyr 
    2585                 2590                 2595             


Gly His  Gly Ala Ala Val Ser  Cys Val Ala Ile Ser  Thr Glu Leu 
    2600                 2605                 2610             


Asp Met  Ala Val Ser Gly Ser  Glu Asp Gly Thr Val  Ile Ile His 
    2615                 2620                 2625             


Thr Val  Arg Arg Gly Gln Phe  Val Ala Ala Leu Arg  Pro Leu Gly 
    2630                 2635                 2640             


Ala Thr  Phe Pro Gly Pro Ile  Phe His Leu Ala Leu  Gly Ser Glu 
    2645                 2650                 2655             


Gly Gln  Ile Val Val Gln Ser  Ser Ala Trp Glu Arg  Pro Gly Ala 
    2660                 2665                 2670             


Gln Val  Thr Tyr Ser Leu His  Leu Tyr Ser Val Asn  Gly Lys Leu 
    2675                 2680                 2685             


Arg Ala  Ser Leu Pro Leu Ala  Glu Gln Pro Thr Ala  Leu Thr Val 
    2690                 2695                 2700             


Thr Glu  Asp Phe Val Leu Leu  Gly Thr Ala Gln Cys  Ala Leu His 
    2705                 2710                 2715             


Ile Leu  Gln Leu Asn Thr Leu  Leu Pro Ala Ala Pro  Pro Leu Pro 
    2720                 2725                 2730             


Met Lys  Val Ala Ile Arg Ser  Val Ala Val Thr Lys  Glu Arg Ser 
    2735                 2740                 2745             


His Val  Leu Val Gly Leu Glu  Asp Gly Lys Leu Ile  Val Val Val 
    2750                 2755                 2760             


Ala Gly  Gln Pro Ser Glu Val  Arg Ser Ser Gln Phe  Ala Arg Lys 
    2765                 2770                 2775             


Leu Trp  Arg Ser Ser Arg Arg  Ile Ser Gln Val Ser  Ser Gly Glu 
    2780                 2785                 2790             


Thr Glu  Tyr Asn Pro Thr Glu  Ala Arg 
    2795                 2800         


<210>  779
<211>  7987
<212>  DNA
<213>  Homosapiens

<400>  779
aatcttcccc accaaagtca agggtggaat tgggcaaaat tcattttaag aaacatctgc     60

ttcatgtaac atccaggcca ctgctggcta ctaccacagc agtagcatct ccacctactc    120

atgcagcacc attaccagca gtgatagcag aatcaacaac tgtagactca ccgccctcat    180

ctccgcctcc accgcctcca cctgcccaag ccacaacact ctcatcacca gcaccagtaa    240

cagagccagt ggccttgcca catacaccaa taacagttct aatggcagca ccagtaccct    300

taccagtaga tgtagcagtt agatctctga aagaaccacc aattataatt gtaccagaat    360

ctttagaagc agatactaag caggacacta tatctaatag tttagaagaa cacgtaactc    420

aaatattgaa tgagcaagca gatatttcct caaaaaaaga agattcccat attgggaagg    480

atgaagaaat tccagatagt tctaagatta gtctgagctg taaaaaaaca ggttctaaga    540

agaaatcctc acaatctgaa ggcatctttc ttggttcaga atctgatgaa gattctgtac    600

ggacttcttc aagtcaaaga tcacatgatt taaaattttc agcaagcatt gaaaaggaaa    660

gagattttaa aaagagctca gcacctttaa aaagtgagga tctagggaaa ccttcacgat    720

ctaaaacaga cagagatgat aaatatttta gctattcaaa acttgaaaga gatactcggt    780

atgtatcttc ccgatgtaga tcagaaagag agcgacggcg gagcagatct cactctaggt    840

ctgagagagg ctctagaact aatttatcct attccaggtc agaacgatct cattattatg    900

actctgatcg tcgctaccat aggagctccc cttatcgaga gaggacgcgc tattctcggc    960

catacacaga taacagagca cgagagagtt ctgactcaga agaagagtat aagaagacat   1020

actcaaggcg tacctcatct cattcctctt cttacagaga cctaaggaca tcatcctatt   1080

ctaaatctga tcgggactgt aaaactgaga cctcttactt agagatggaa agaagaggca   1140

agtattcttc aaaactagaa agagaatcta aaaggacttc agaaaatgaa gcaattaaaa   1200

gatgttgttc tccccctaat gaactgggat tccgacgagg gtcatcatat tctaagcatg   1260

acagtagtgc ttcccgttat aaatctaccc tttcaaaacc tatacccaag tctgataaat   1320

ttaaaaattc tttctgttgt acagaattaa atgaagaaat caaacagtct cattctttta   1380

gtttacagac accttgttca aaaggtagtg aattaagaat gattaataaa aatcctgaaa   1440

gagaaaaggc tgggtctcca gctccatcaa atcgattaaa tgattcacct actttaaaaa   1500

agctagatga attgcctatt tttaagtccg aatttataac acatgatagc catgatagta   1560

ttaaggaatt agactcttta tctaaagtga agaatgatca attaagaagt ttttgtccca   1620

tagaattaaa tataaatgga tctcctgggg cagaatctga tttggcaaca ttttgcactt   1680

ctaaaactga tgctgtttta atgacttctg atgatagtgt gactggatcg gaattatccc   1740

ctttggtcaa agcatgcatg ctttcatcaa atggatttca gaatattagt aggtgcaaag   1800

aaaaagactt ggatgatacc tgcatgctgc ataagaagtc agaaagccca tttagagaaa   1860

cagaacctct ggtgtcacca caccaagata aactcatgtc tatgccagtt atgactgtgg   1920

attattccaa aacagtagtt aaagaaccag ttgatacgag ggtttcttgc tgcaaaacca   1980

aagattcaga catatactgt actttgaacg atagcaaccc ttctttgtgt aactctgaag   2040

ctgaaaatat tgagccttca gttatgaaga tttcttcaaa tagctttatg aatgtgcatt   2100

tggaatcaaa accagttata tgtgatagta gaaatttgac agatcactca aaatttgcat   2160

gtgaagaata taagcagagc atcggtagca ctagttcagc ttctgttaat cattttgatg   2220

atttatatca acctattggg agttcaggta ttgcttcatc tcttcagagt cttccaccag   2280

gaataaaggt ggacagtcta actctcttga aatgcggaga gaacacatct ccagttctgg   2340

atgcagtgct aaagagtaaa aaaagttcag agtttttaaa gcatgcaggg aaagaaacaa   2400

tagtagaagt aggtagtgac cttcctgatt caggaaaggg atttgcttcc agggagaaca   2460

ggcgtaataa tgggttatct gggaaatgtt tgcaagaggc tcaagaagaa gggaattcca   2520

tattgcctga aagaagagga agaccagaaa tctctttaga tgaaagagga gaaggaggac   2580

atgtgcatac ttctgatgac tcagaagttg tattttcttc ttgtgatttg aatttaacca   2640

tggaagacag tgatggtgta acttatgcat taaagtgtga cagtagtggt catgccccag   2700

aaattgtgtc tacagttcat gaagattatt ctggctcttc tgaaagttca aatgatgaaa   2760

gtgattcaga agatacagat tcggatgata gcagtattcc aagaaaccgt ctccagtctg   2820

ttgtggttgt gccaaagaat tctactttgc ccatggaaga aacaagtcct tgttcttctc   2880

ggagcagtca aagttataga cactattctg accattggga agatgagaga ttggagtcaa   2940

ggagacattt gtatgaggaa aaatttgaaa gtatagcaag taaagcctgt cctcaaactg   3000

ataagttttt ccttcataaa ggaacagaga agaatccgga aatttctttt acacagtcca   3060

gtagaaaaca aatagataat cgcctgcctg aactttctca tcctcagagt gatggggttg   3120

atagtacaag tcatacagat gtgaaatctg accctctggg tcacccaaat tcagaggaaa   3180

ccgtgaaagc caaaatacct tctaggcagc aagaagagct gccaatttat tcttctgatt   3240

ttgaagatgt cccaaataag tcttggcaac agaccacttt ccaaaacagg ccagatagta   3300

gactgggaaa aacagaattg agtttttctt cctcttgtga gataccacat gtggatggct   3360

tgcactcatc agaagagctc agaaacttag gttgggactt ctctcaagaa aagccttcta   3420

ccacgtatca gcaacctgac agtagctatg gagcttgtgg tggacacaag tatcagcaaa   3480

atgcagaaca gtatggtggg acacgtgatt actggcaagg caatggttac tgggatccaa   3540

gatcaggtag acctcctgga actggggttg tgtatgatcg aactcaagga caagtaccag   3600

attccctaac agatgatcgt gaagaagagg agaattggga tcaacaggat ggatcccatt   3660

tttcagacca gtccgataaa tttcttctat cccttcagaa agacaagggg tcagtgcaag   3720

cacctgaaat aagcagcaat tccattaagg acactttagc tgtgaatgaa aagaaagatt   3780

tttcaaaaaa cttagaaaaa aatgatatca aagatagagg gcctcttaaa aaaaggaggc   3840

aggaaataga gagtgattct gaaagtgatg gtgagcttca ggacagaaag aaagttagag   3900

tggaggtaga gcagggagag acatcagtgc ccccaggttc agcactggtt gggccctcct   3960

gtgtcatgga tgacttcagg gacccacagc gatggaagga atgtgccaag caagggaaaa   4020

tgccatgtta ctttgatctt attgaagaaa atgtttattt aacagaaaga aagaagaata   4080

aatctcatcg agatattaag cgaatgcagt gtgagtgtac acctctttct aaagatgaaa   4140

gagctcaagg tgaaatagca tgtggggaag attgtcttaa tcgtcttctc atgattgaat   4200

gttcttctcg gtgtccaaat ggggattatt gttccaatag acggtttcag agaaaacagc   4260

atgcagatgt ggaagtcata ctcacagaaa agaaaggctg gggcttgaga gctgccaaag   4320

accttccttc gaacaccttt gtcctagaat attgtggaga ggtactcgat cataaagagt   4380

ttaaagctcg agtgaaggag tatgcacgaa acaaaaacat ccattactat ttcatggccc   4440

tgaagaatga tgagataata gatgccactc aaaaaggaaa ttgctctcgt ttcatgaatc   4500

acagctgtga accaaattgt gaaacccaaa aatggactgt gaacggacaa ctgagggttg   4560

ggttttttac caccaaactg gttccttcag gctcagagtt aacgtttgac tatcagttcc   4620

agagatatgg aaaagaagcc cagaaatgtt tctgcggatc agccaattgc cggggttacc   4680

tgggaggaga aaacagagtc agcatcagag cagcaggagg gaaaatgaag aaggaacgat   4740

ctcgtaagaa ggattcagtg gatggagagc tagaagctct gatggaaaat ggtgagggtc   4800

tctctgataa aaaccaggtg ctcagcttat cccggctaat ggttagaatt gaaactttgg   4860

agcagaaact tacctgtctg gaactcatac agaacacaca ctcacagtcc tgcctgaagt   4920

cctttctgga acgtcatggg ctgtctttgt tgtggatctg gatggcagag ctaggtgacg   4980

gccgggaaag taaccagaag cttcaggaag agattataaa gactttggaa cacttgccca   5040

ttcctactaa aaatatgttg gaggaaagca aagtacttcc aattattcaa cgctggtctc   5100

agactaagac tgctgtccct ccgttgagtg aaggagatgg gtattctagt gagaatacat   5160

cgcgtgctca tacaccactc aacacacctg atccttccac caagctgagc acagaagctg   5220

acacagacac tcccaagaaa ctaatgtttc gcagactgaa aattataagt gaaaatagca   5280

tggacagtgc aatctctgat gcaaccagtg agctagaagg caaggatggc aaagaggatc   5340

ttgatcaatt agaaaatgtc cctgtagagg aagaggaaga attgcagtca caacagctac   5400

tcccacaaca gctgcctgaa tgcaaagttg atagtgaaac caacatagaa gctagtaagc   5460

tacctacatc tgaaccagaa gctgacgctg aaatagagcc caaagagagc aacggcacaa   5520

aactagaaga acctattaat gaagaaacac catcccaaga tgaagaggag ggtgtgtctg   5580

atgtggagag tgaaaggagc caagaacagc cagataaaac agtggatata agtgatttgg   5640

ccaccaaact cctggacagt tggaaagacc taaaggaggt atatcgaatt ccaaagaaaa   5700

gtcaaactga aaaggaaaac acaacaactg aacgaggaag ggatgctgtt ggcttcagag   5760

atcaaacacc tgccccgaag actcctaata ggtcaagaga gagagaccca gacaagcaaa   5820

ctcaaaataa agagaaaagg aaacgaagaa gctccctctc accaccctct tctgcctatg   5880

agcggggaac aaaaaggcca gatgacagat atgatacacc aacttctaaa aagaaagtac   5940

gaattaaaga ccgcaataaa ctttctacag aggaacgccg gaagttgttt gagcaagagg   6000

tggctcaacg ggaggctcag aaacaacagc aacagatgca gaacctggga atgacatcac   6060

cactgcccta tgactctctt ggttataatg ccccgcatca tccctttgct ggttacccac   6120

caggttatcc catgcaggcc tatgtggatc ccagcaaccc taatgctgga aaggtgctcc   6180

tgcccacacc cagcatggac ccagtgtgtt ctcctgctcc ttatgatcat gctcagccct   6240

tggtgggaca ttctacagaa cccctttctg cccctccacc agtaccagtg gtgccacatg   6300

tggcagctcc tgtggaagtt tccagttccc agtatgtggc ccagagtgat ggtgtagtac   6360

accaagactc cagcgttgct gtcttgccag tgccggcccc cggcccagtt cagggacaga   6420

attatagtgt ttgggattca aaccaacagt ctgtcagtgt acagcagcag tactctcctg   6480

cacagtctca agcaaccata tattatcaag gacagacatg tccaacagtc tatggtgtga   6540

catcacctta ttcacagaca actccaccaa ttgtacagag ttatgcccag ccaagtcttc   6600

agtatatcca ggggcaacag attttcacag ctcatccaca aggagtggtg gtacagccag   6660

ccgcagcagt gactacaata gttgcaccag ggcagcctca gcccttgcag ccatctgaaa   6720

tggttgtgac aaataatctc ttggatctgc cgcccccctc tcctcccaaa ccaaaaacca   6780

ttgtcttacc tcccaactgg aagacagctc gagatccaga agggaagatt tattactacc   6840

atgtgatcac aaggcagact cagtgggatc ctcctacttg ggaaagccca ggagatgatg   6900

ccagccttga gcatgaagct gagatggacc tgggaactcc aacatatgat gaaaacccca   6960

tgaaggcctc gaaaaagccc aagacagcag aagcagacac ctccagtgaa ctagcaaaga   7020

aaagcaaaga agtattcaga aaagagatgt cccagttcat cgtccagtgc ctgaaccctt   7080

accggaaacc tgactgcaaa gtgggaagaa ttaccacaac tgaagacttt aaacatctgg   7140

ctcgcaagct gactcacggt gttatgaata aggagctgaa gtactgtaag aatcctgagg   7200

acctggagtg caatgagaat gtgaaacaca aaaccaagga gtacattaag aagtacatgc   7260

agaagtttgg ggctgtttac aaacccaaag aggacactga attagagtga ctgttgggcc   7320

agggtgggag gatgggtggt caggtaagac agactctagg gagaggaaat cctgtgggcc   7380

tttctgtccc acccctgtca gcactgtgct actgatgata catcaccctg gggaattcaa   7440

ccctgcagat gtcaactgaa ggccacaaaa atgaactcca tctacaagtg attacctagt   7500

tgtgagctgt tggcatgtgg ttagaagcca tcagaggtgc aagggcttag aaaagaccct   7560

ggccagacct gactccactc ttaaacctgg gtcttctcct tggcggtgct gtcagcgcac   7620

agacccatgc gcatccccac ccacaaccct ttaccctgat gatctgtatt atattttaat   7680

gtatatgtga atatattgaa aataatttgt tttttcctgg tttttgtttg gttttcgttt   7740

tgcttttagc ctctacatgc taggatcaca ggaagacttt gtaaggacag tttaagttct   7800

cctgcaaggt ttaatttgtt atcatgtaaa tattctaaag caggctgcct tgtggttttg   7860

gccagccttg tgctatgttg ataagattga tttactgctt aaaatcactt tactttatcc   7920

aatttttact gaacttttta tgtaaaaaaa taaaatcaat taaagaactt ggcatgtgtg   7980

ttcccta                                                             7987


<210>  780
<211>  2061
<212>  PRT
<213>  Homosapiens

<400>  780

Met Glu Arg Arg Gly Lys Tyr Ser Ser Lys Leu Glu Arg Glu Ser Lys 
1               5                   10                  15      


Arg Thr Ser Glu Asn Glu Ala Ile Lys Arg Cys Cys Ser Pro Pro Asn 
            20                  25                  30          


Glu Leu Gly Phe Arg Arg Gly Ser Ser Tyr Ser Lys His Asp Ser Ser 
        35                  40                  45              


Ala Ser Arg Tyr Lys Ser Thr Leu Ser Lys Pro Ile Pro Lys Ser Asp 
    50                  55                  60                  


Lys Phe Lys Asn Ser Phe Cys Cys Thr Glu Leu Asn Glu Glu Ile Lys 
65                  70                  75                  80  


Gln Ser His Ser Phe Ser Leu Gln Thr Pro Cys Ser Lys Gly Ser Glu 
                85                  90                  95      


Leu Arg Met Ile Asn Lys Asn Pro Glu Arg Glu Lys Ala Gly Ser Pro 
            100                 105                 110         


Ala Pro Ser Asn Arg Leu Asn Asp Ser Pro Thr Leu Lys Lys Leu Asp 
        115                 120                 125             


Glu Leu Pro Ile Phe Lys Ser Glu Phe Ile Thr His Asp Ser His Asp 
    130                 135                 140                 


Ser Ile Lys Glu Leu Asp Ser Leu Ser Lys Val Lys Asn Asp Gln Leu 
145                 150                 155                 160 


Arg Ser Phe Cys Pro Ile Glu Leu Asn Ile Asn Gly Ser Pro Gly Ala 
                165                 170                 175     


Glu Ser Asp Leu Ala Thr Phe Cys Thr Ser Lys Thr Asp Ala Val Leu 
            180                 185                 190         


Met Thr Ser Asp Asp Ser Val Thr Gly Ser Glu Leu Ser Pro Leu Val 
        195                 200                 205             


Lys Ala Cys Met Leu Ser Ser Asn Gly Phe Gln Asn Ile Ser Arg Cys 
    210                 215                 220                 


Lys Glu Lys Asp Leu Asp Asp Thr Cys Met Leu His Lys Lys Ser Glu 
225                 230                 235                 240 


Ser Pro Phe Arg Glu Thr Glu Pro Leu Val Ser Pro His Gln Asp Lys 
                245                 250                 255     


Leu Met Ser Met Pro Val Met Thr Val Asp Tyr Ser Lys Thr Val Val 
            260                 265                 270         


Lys Glu Pro Val Asp Thr Arg Val Ser Cys Cys Lys Thr Lys Asp Ser 
        275                 280                 285             


Asp Ile Tyr Cys Thr Leu Asn Asp Ser Asn Pro Ser Leu Cys Asn Ser 
    290                 295                 300                 


Glu Ala Glu Asn Ile Glu Pro Ser Val Met Lys Ile Ser Ser Asn Ser 
305                 310                 315                 320 


Phe Met Asn Val His Leu Glu Ser Lys Pro Val Ile Cys Asp Ser Arg 
                325                 330                 335     


Asn Leu Thr Asp His Ser Lys Phe Ala Cys Glu Glu Tyr Lys Gln Ser 
            340                 345                 350         


Ile Gly Ser Thr Ser Ser Ala Ser Val Asn His Phe Asp Asp Leu Tyr 
        355                 360                 365             


Gln Pro Ile Gly Ser Ser Gly Ile Ala Ser Ser Leu Gln Ser Leu Pro 
    370                 375                 380                 


Pro Gly Ile Lys Val Asp Ser Leu Thr Leu Leu Lys Cys Gly Glu Asn 
385                 390                 395                 400 


Thr Ser Pro Val Leu Asp Ala Val Leu Lys Ser Lys Lys Ser Ser Glu 
                405                 410                 415     


Phe Leu Lys His Ala Gly Lys Glu Thr Ile Val Glu Val Gly Ser Asp 
            420                 425                 430         


Leu Pro Asp Ser Gly Lys Gly Phe Ala Ser Arg Glu Asn Arg Arg Asn 
        435                 440                 445             


Asn Gly Leu Ser Gly Lys Cys Leu Gln Glu Ala Gln Glu Glu Gly Asn 
    450                 455                 460                 


Ser Ile Leu Pro Glu Arg Arg Gly Arg Pro Glu Ile Ser Leu Asp Glu 
465                 470                 475                 480 


Arg Gly Glu Gly Gly His Val His Thr Ser Asp Asp Ser Glu Val Val 
                485                 490                 495     


Phe Ser Ser Cys Asp Leu Asn Leu Thr Met Glu Asp Ser Asp Gly Val 
            500                 505                 510         


Thr Tyr Ala Leu Lys Cys Asp Ser Ser Gly His Ala Pro Glu Ile Val 
        515                 520                 525             


Ser Thr Val His Glu Asp Tyr Ser Gly Ser Ser Glu Ser Ser Asn Asp 
    530                 535                 540                 


Glu Ser Asp Ser Glu Asp Thr Asp Ser Asp Asp Ser Ser Ile Pro Arg 
545                 550                 555                 560 


Asn Arg Leu Gln Ser Val Val Val Val Pro Lys Asn Ser Thr Leu Pro 
                565                 570                 575     


Met Glu Glu Thr Ser Pro Cys Ser Ser Arg Ser Ser Gln Ser Tyr Arg 
            580                 585                 590         


His Tyr Ser Asp His Trp Glu Asp Glu Arg Leu Glu Ser Arg Arg His 
        595                 600                 605             


Leu Tyr Glu Glu Lys Phe Glu Ser Ile Ala Ser Lys Ala Cys Pro Gln 
    610                 615                 620                 


Thr Asp Lys Phe Phe Leu His Lys Gly Thr Glu Lys Asn Pro Glu Ile 
625                 630                 635                 640 


Ser Phe Thr Gln Ser Ser Arg Lys Gln Ile Asp Asn Arg Leu Pro Glu 
                645                 650                 655     


Leu Ser His Pro Gln Ser Asp Gly Val Asp Ser Thr Ser His Thr Asp 
            660                 665                 670         


Val Lys Ser Asp Pro Leu Gly His Pro Asn Ser Glu Glu Thr Val Lys 
        675                 680                 685             


Ala Lys Ile Pro Ser Arg Gln Gln Glu Glu Leu Pro Ile Tyr Ser Ser 
    690                 695                 700                 


Asp Phe Glu Asp Val Pro Asn Lys Ser Trp Gln Gln Thr Thr Phe Gln 
705                 710                 715                 720 


Asn Arg Pro Asp Ser Arg Leu Gly Lys Thr Glu Leu Ser Phe Ser Ser 
                725                 730                 735     


Ser Cys Glu Ile Pro His Val Asp Gly Leu His Ser Ser Glu Glu Leu 
            740                 745                 750         


Arg Asn Leu Gly Trp Asp Phe Ser Gln Glu Lys Pro Ser Thr Thr Tyr 
        755                 760                 765             


Gln Gln Pro Asp Ser Ser Tyr Gly Ala Cys Gly Gly His Lys Tyr Gln 
    770                 775                 780                 


Gln Asn Ala Glu Gln Tyr Gly Gly Thr Arg Asp Tyr Trp Gln Gly Asn 
785                 790                 795                 800 


Gly Tyr Trp Asp Pro Arg Ser Gly Arg Pro Pro Gly Thr Gly Val Val 
                805                 810                 815     


Tyr Asp Arg Thr Gln Gly Gln Val Pro Asp Ser Leu Thr Asp Asp Arg 
            820                 825                 830         


Glu Glu Glu Glu Asn Trp Asp Gln Gln Asp Gly Ser His Phe Ser Asp 
        835                 840                 845             


Gln Ser Asp Lys Phe Leu Leu Ser Leu Gln Lys Asp Lys Gly Ser Val 
    850                 855                 860                 


Gln Ala Pro Glu Ile Ser Ser Asn Ser Ile Lys Asp Thr Leu Ala Val 
865                 870                 875                 880 


Asn Glu Lys Lys Asp Phe Ser Lys Asn Leu Glu Lys Asn Asp Ile Lys 
                885                 890                 895     


Asp Arg Gly Pro Leu Lys Lys Arg Arg Gln Glu Ile Glu Ser Asp Ser 
            900                 905                 910         


Glu Ser Asp Gly Glu Leu Gln Asp Arg Lys Lys Val Arg Val Glu Val 
        915                 920                 925             


Glu Gln Gly Glu Thr Ser Val Pro Pro Gly Ser Ala Leu Val Gly Pro 
    930                 935                 940                 


Ser Cys Val Met Asp Asp Phe Arg Asp Pro Gln Arg Trp Lys Glu Cys 
945                 950                 955                 960 


Ala Lys Gln Gly Lys Met Pro Cys Tyr Phe Asp Leu Ile Glu Glu Asn 
                965                 970                 975     


Val Tyr Leu Thr Glu Arg Lys Lys Asn Lys Ser His Arg Asp Ile Lys 
            980                 985                 990         


Arg Met Gln Cys Glu Cys Thr Pro  Leu Ser Lys Asp Glu  Arg Ala Gln 
        995                 1000                 1005             


Gly Glu  Ile Ala Cys Gly Glu  Asp Cys Leu Asn Arg  Leu Leu Met 
    1010                 1015                 1020             


Ile Glu  Cys Ser Ser Arg Cys  Pro Asn Gly Asp Tyr  Cys Ser Asn 
    1025                 1030                 1035             


Arg Arg  Phe Gln Arg Lys Gln  His Ala Asp Val Glu  Val Ile Leu 
    1040                 1045                 1050             


Thr Glu  Lys Lys Gly Trp Gly  Leu Arg Ala Ala Lys  Asp Leu Pro 
    1055                 1060                 1065             


Ser Asn  Thr Phe Val Leu Glu  Tyr Cys Gly Glu Val  Leu Asp His 
    1070                 1075                 1080             


Lys Glu  Phe Lys Ala Arg Val  Lys Glu Tyr Ala Arg  Asn Lys Asn 
    1085                 1090                 1095             


Ile His  Tyr Tyr Phe Met Ala  Leu Lys Asn Asp Glu  Ile Ile Asp 
    1100                 1105                 1110             


Ala Thr  Gln Lys Gly Asn Cys  Ser Arg Phe Met Asn  His Ser Cys 
    1115                 1120                 1125             


Glu Pro  Asn Cys Glu Thr Gln  Lys Trp Thr Val Asn  Gly Gln Leu 
    1130                 1135                 1140             


Arg Val  Gly Phe Phe Thr Thr  Lys Leu Val Pro Ser  Gly Ser Glu 
    1145                 1150                 1155             


Leu Thr  Phe Asp Tyr Gln Phe  Gln Arg Tyr Gly Lys  Glu Ala Gln 
    1160                 1165                 1170             


Lys Cys  Phe Cys Gly Ser Ala  Asn Cys Arg Gly Tyr  Leu Gly Gly 
    1175                 1180                 1185             


Glu Asn  Arg Val Ser Ile Arg  Ala Ala Gly Gly Lys  Met Lys Lys 
    1190                 1195                 1200             


Glu Arg  Ser Arg Lys Lys Asp  Ser Val Asp Gly Glu  Leu Glu Ala 
    1205                 1210                 1215             


Leu Met  Glu Asn Gly Glu Gly  Leu Ser Asp Lys Asn  Gln Val Leu 
    1220                 1225                 1230             


Ser Leu  Ser Arg Leu Met Val  Arg Ile Glu Thr Leu  Glu Gln Lys 
    1235                 1240                 1245             


Leu Thr  Cys Leu Glu Leu Ile  Gln Asn Thr His Ser  Gln Ser Cys 
    1250                 1255                 1260             


Leu Lys  Ser Phe Leu Glu Arg  His Gly Leu Ser Leu  Leu Trp Ile 
    1265                 1270                 1275             


Trp Met  Ala Glu Leu Gly Asp  Gly Arg Glu Ser Asn  Gln Lys Leu 
    1280                 1285                 1290             


Gln Glu  Glu Ile Ile Lys Thr  Leu Glu His Leu Pro  Ile Pro Thr 
    1295                 1300                 1305             


Lys Asn  Met Leu Glu Glu Ser  Lys Val Leu Pro Ile  Ile Gln Arg 
    1310                 1315                 1320             


Trp Ser  Gln Thr Lys Thr Ala  Val Pro Pro Leu Ser  Glu Gly Asp 
    1325                 1330                 1335             


Gly Tyr  Ser Ser Glu Asn Thr  Ser Arg Ala His Thr  Pro Leu Asn 
    1340                 1345                 1350             


Thr Pro  Asp Pro Ser Thr Lys  Leu Ser Thr Glu Ala  Asp Thr Asp 
    1355                 1360                 1365             


Thr Pro  Lys Lys Leu Met Phe  Arg Arg Leu Lys Ile  Ile Ser Glu 
    1370                 1375                 1380             


Asn Ser  Met Asp Ser Ala Ile  Ser Asp Ala Thr Ser  Glu Leu Glu 
    1385                 1390                 1395             


Gly Lys  Asp Gly Lys Glu Asp  Leu Asp Gln Leu Glu  Asn Val Pro 
    1400                 1405                 1410             


Val Glu  Glu Glu Glu Glu Leu  Gln Ser Gln Gln Leu  Leu Pro Gln 
    1415                 1420                 1425             


Gln Leu  Pro Glu Cys Lys Val  Asp Ser Glu Thr Asn  Ile Glu Ala 
    1430                 1435                 1440             


Ser Lys  Leu Pro Thr Ser Glu  Pro Glu Ala Asp Ala  Glu Ile Glu 
    1445                 1450                 1455             


Pro Lys  Glu Ser Asn Gly Thr  Lys Leu Glu Glu Pro  Ile Asn Glu 
    1460                 1465                 1470             


Glu Thr  Pro Ser Gln Asp Glu  Glu Glu Gly Val Ser  Asp Val Glu 
    1475                 1480                 1485             


Ser Glu  Arg Ser Gln Glu Gln  Pro Asp Lys Thr Val  Asp Ile Ser 
    1490                 1495                 1500             


Asp Leu  Ala Thr Lys Leu Leu  Asp Ser Trp Lys Asp  Leu Lys Glu 
    1505                 1510                 1515             


Val Tyr  Arg Ile Pro Lys Lys  Ser Gln Thr Glu Lys  Glu Asn Thr 
    1520                 1525                 1530             


Thr Thr  Glu Arg Gly Arg Asp  Ala Val Gly Phe Arg  Asp Gln Thr 
    1535                 1540                 1545             


Pro Ala  Pro Lys Thr Pro Asn  Arg Ser Arg Glu Arg  Asp Pro Asp 
    1550                 1555                 1560             


Lys Gln  Thr Gln Asn Lys Glu  Lys Arg Lys Arg Arg  Ser Ser Leu 
    1565                 1570                 1575             


Ser Pro  Pro Ser Ser Ala Tyr  Glu Arg Gly Thr Lys  Arg Pro Asp 
    1580                 1585                 1590             


Asp Arg  Tyr Asp Thr Pro Thr  Ser Lys Lys Lys Val  Arg Ile Lys 
    1595                 1600                 1605             


Asp Arg  Asn Lys Leu Ser Thr  Glu Glu Arg Arg Lys  Leu Phe Glu 
    1610                 1615                 1620             


Gln Glu  Val Ala Gln Arg Glu  Ala Gln Lys Gln Gln  Gln Gln Met 
    1625                 1630                 1635             


Gln Asn  Leu Gly Met Thr Ser  Pro Leu Pro Tyr Asp  Ser Leu Gly 
    1640                 1645                 1650             


Tyr Asn  Ala Pro His His Pro  Phe Ala Gly Tyr Pro  Pro Gly Tyr 
    1655                 1660                 1665             


Pro Met  Gln Ala Tyr Val Asp  Pro Ser Asn Pro Asn  Ala Gly Lys 
    1670                 1675                 1680             


Val Leu  Leu Pro Thr Pro Ser  Met Asp Pro Val Cys  Ser Pro Ala 
    1685                 1690                 1695             


Pro Tyr  Asp His Ala Gln Pro  Leu Val Gly His Ser  Thr Glu Pro 
    1700                 1705                 1710             


Leu Ser  Ala Pro Pro Pro Val  Pro Val Val Pro His  Val Ala Ala 
    1715                 1720                 1725             


Pro Val  Glu Val Ser Ser Ser  Gln Tyr Val Ala Gln  Ser Asp Gly 
    1730                 1735                 1740             


Val Val  His Gln Asp Ser Ser  Val Ala Val Leu Pro  Val Pro Ala 
    1745                 1750                 1755             


Pro Gly  Pro Val Gln Gly Gln  Asn Tyr Ser Val Trp  Asp Ser Asn 
    1760                 1765                 1770             


Gln Gln  Ser Val Ser Val Gln  Gln Gln Tyr Ser Pro  Ala Gln Ser 
    1775                 1780                 1785             


Gln Ala  Thr Ile Tyr Tyr Gln  Gly Gln Thr Cys Pro  Thr Val Tyr 
    1790                 1795                 1800             


Gly Val  Thr Ser Pro Tyr Ser  Gln Thr Thr Pro Pro  Ile Val Gln 
    1805                 1810                 1815             


Ser Tyr  Ala Gln Pro Ser Leu  Gln Tyr Ile Gln Gly  Gln Gln Ile 
    1820                 1825                 1830             


Phe Thr  Ala His Pro Gln Gly  Val Val Val Gln Pro  Ala Ala Ala 
    1835                 1840                 1845             


Val Thr  Thr Ile Val Ala Pro  Gly Gln Pro Gln Pro  Leu Gln Pro 
    1850                 1855                 1860             


Ser Glu  Met Val Val Thr Asn  Asn Leu Leu Asp Leu  Pro Pro Pro 
    1865                 1870                 1875             


Ser Pro  Pro Lys Pro Lys Thr  Ile Val Leu Pro Pro  Asn Trp Lys 
    1880                 1885                 1890             


Thr Ala  Arg Asp Pro Glu Gly  Lys Ile Tyr Tyr Tyr  His Val Ile 
    1895                 1900                 1905             


Thr Arg  Gln Thr Gln Trp Asp  Pro Pro Thr Trp Glu  Ser Pro Gly 
    1910                 1915                 1920             


Asp Asp  Ala Ser Leu Glu His  Glu Ala Glu Met Asp  Leu Gly Thr 
    1925                 1930                 1935             


Pro Thr  Tyr Asp Glu Asn Pro  Met Lys Ala Ser Lys  Lys Pro Lys 
    1940                 1945                 1950             


Thr Ala  Glu Ala Asp Thr Ser  Ser Glu Leu Ala Lys  Lys Ser Lys 
    1955                 1960                 1965             


Glu Val  Phe Arg Lys Glu Met  Ser Gln Phe Ile Val  Gln Cys Leu 
    1970                 1975                 1980             


Asn Pro  Tyr Arg Lys Pro Asp  Cys Lys Val Gly Arg  Ile Thr Thr 
    1985                 1990                 1995             


Thr Glu  Asp Phe Lys His Leu  Ala Arg Lys Leu Thr  His Gly Val 
    2000                 2005                 2010             


Met Asn  Lys Glu Leu Lys Tyr  Cys Lys Asn Pro Glu  Asp Leu Glu 
    2015                 2020                 2025             


Cys Asn  Glu Asn Val Lys His  Lys Thr Lys Glu Tyr  Ile Lys Lys 
    2030                 2035                 2040             


Tyr Met  Gln Lys Phe Gly Ala  Val Tyr Lys Pro Lys  Glu Asp Thr 
    2045                 2050                 2055             


Glu Leu  Glu 
    2060     


<210>  781
<211>  7193
<212>  DNA
<213>  Homosapiens

<400>  781
agaataaggg cagggaccgc ggctcctatc tcttggtgat ccccttcccc attccgcccc     60

cgcctcaacg cccagcacag tgccctgcac acagtagtcg ctcaataaat gttcgtggat    120

gatgatgatg atgatgatga aaaaaatgca gcatcaacgg cagcagcaag cggaccacgc    180

gaacgaggca aactatgcaa gaggcaccag acttcctctt tctggtgaag gaccaacttc    240

tcagccgaat agctccaagc aaactgtcct gtcttggcaa gctgcaatcg atgctgctag    300

acaggccaag gctgcccaaa ctatgagcac ctctgcaccc ccacctgtag gatctctctc    360

ccaaagaaaa cgtcagcaat acgccaagag caaaaaacag ggtaactcgt ccaacagccg    420

acctgcccgc gcccttttct gtttatcact caataacccc atccgaagag cctgcattag    480

tatagtggaa tggaaaccat ttgacatatt tatattattg gctatttttg ccaattgtgt    540

ggccttagct atttacatcc cattccctga agatgattct aattcaacaa atcataactt    600

ggaaaaagta gaatatgcct tcctgattat ttttacagtc gagacatttt tgaagattat    660

agcgtatgga ttattgctac atcctaatgc ttatgttagg aatggatgga atttactgga    720

ttttgttata gtaatagtag gattgtttag tgtaattttg gaacaattaa ccaaagaaac    780

agaaggcggg aaccactcaa gcggcaaatc tggaggcttt gatgtcaaag ccctccgtgc    840

ctttcgagtg ttgcgaccac ttcgactagt gtcaggggtg cccagtttac aagttgtcct    900

gaactccatt ataaaagcca tggttcccct ccttcacata gcccttttgg tattatttgt    960

aatcataatc tatgctatta taggattgga actttttatt ggaaaaatgc acaaaacatg   1020

tttttttgct gactcagata tcgtagctga agaggaccca gctccatgtg cgttctcagg   1080

gaatggacgc cagtgtactg ccaatggcac ggaatgtagg agtggctggg ttggcccgaa   1140

cggaggcatc accaactttg ataactttgc ctttgccatg cttactgtgt ttcagtgcat   1200

caccatggag ggctggacag acgtgctcta ctgggtaaat gatgcgatag gatgggaatg   1260

gccatgggtg tattttgtta gtctgatcat ccttggctca tttttcgtcc ttaacctggt   1320

tcttggtgtc cttagtggag aattctcaaa ggaaagagag aaggcaaaag cacggggaga   1380

tttccagaag ctccgggaga agcagcagct ggaggaggat ctaaagggct acttggattg   1440

gatcacccaa gctgaggaca tcgatccgga gaatgaggaa gaaggaggag aggaaggcaa   1500

acgaaatact agcatgccca ccagcgagac tgagtctgtg aacacagaga acgtcagcgg   1560

tgaaggcgag aaccgaggct gctgtggaag tctctggtgc tggtggagac ggagaggcgc   1620

ggccaaggcg gggccctctg ggtgtcggcg gtggggtcaa gccatctcaa aatccaaact   1680

cagccgacgc tggcgtcgct ggaaccgatt caatcgcaga agatgtaggg ccgccgtgaa   1740

gtctgtcacg ttttactggc tggttatcgt cctggtgttt ctgaacacct taaccatttc   1800

ctctgagcac tacaatcagc cagattggtt gacacagatt caagatattg ccaacaaagt   1860

cctcttggct ctgttcacct gcgagatgct ggtaaaaatg tacagcttgg gcctccaagc   1920

atatttcgtc tctcttttca accggtttga ttgcttcgtg gtgtgtggtg gaatcactga   1980

gacgatcctg gtggaactgg aaatcatgtc tcccctgggg atctctgtgt ttcggtgtgt   2040

gcgcctctta agaatcttca aagtgaccag gcactggact tccctgagca acttagtggc   2100

atccttatta aactccatga agtccatcgc ttcgctgttg cttctgcttt ttctcttcat   2160

tatcatcttt tccttgcttg ggatgcagct gtttggcggc aagtttaatt ttgatgaaac   2220

gcaaaccaag cggagcacct ttgacaattt ccctcaagca cttctcacag tgttccagat   2280

cctgacaggc gaagactgga atgctgtgat gtacgatggc atcatggctt acgggggccc   2340

atcctcttca ggaatgatcg tctgcatcta cttcatcatc ctcttcattt gtggtaacta   2400

tattctactg aatgtcttct tggccatcgc tgtagacaat ttggctgatg ctgaaagtct   2460

gaacactgct cagaaagaag aagcggaaga aaaggagagg aaaaagattg ccagaaaaga   2520

gagcctagaa aataaaaaga acaacaaacc agaagtcaac cagatagcca acagtgacaa   2580

caaggttaca attgatgact atagagaaga ggatgaagac aaggacccct atccgccttg   2640

cgatgtgcca gtaggggaag aggaagagga agaggaggag gatgaacctg aggttcctgc   2700

cggaccccgt cctcgaagga tctcggagtt gaacatgaag gaaaaaattg cccccatccc   2760

tgaagggagc gctttcttca ttcttagcaa gaccaacccg atccgcgtag gctgccacaa   2820

gctcatcaac caccacatct tcaccaacct catccttgtc ttcatcatgc tgagcagcgc   2880

tgccctggcc gcagaggacc ccatccgcag ccactccttc cggaacacga tactgggtta   2940

ctttgactat gccttcacag ccatctttac tgttgagatc ctgttgaaga tgacaacttt   3000

tggagctttc ctccacaaag gggccttctg caggaactac ttcaatttgc tggatatgct   3060

ggtggttggg gtgtctctgg tgtcatttgg gattcaatcc agtgccatct ccgttgtgaa   3120

gattctgagg gtcttaaggg tcctgcgtcc cctcagggcc atcaacagag caaaaggact   3180

taagcacgtg gtccagtgcg tcttcgtggc catccggacc atcggcaaca tcatgatcgt   3240

cactaccctc ctgcagttca tgtttgcctg tatcggggtc cagttgttca aggggaagtt   3300

ctatcgctgt acggatgaag ccaaaagtaa ccctgaagaa tgcaggggac ttttcatcct   3360

ctacaaggat ggggatgttg acagtcctgt ggtccgtgaa cggatctggc aaaacagtga   3420

tttcaacttc gacaacgtcc tctctgctat gatggcgctc ttcacagtct ccacgtttga   3480

gggctggcct gcgttgctgt ataaagccat cgactcgaat ggagagaaca tcggcccaat   3540

ctacaaccac cgcgtggaga tctccatctt cttcatcatc tacatcatca ttgtagcttt   3600

cttcatgatg aacatctttg tgggctttgt catcgttaca tttcaggaac aaggagaaaa   3660

agagtataag aactgtgagc tggacaaaaa tcagcgtcag tgtgttgaat acgccttgaa   3720

agcacgtccc ttgcggagat acatccccaa aaacccctac cagtacaagt tctggtacgt   3780

ggtgaactct tcgcctttcg aatacatgat gtttgtcctc atcatgctca acacactctg   3840

cttggccatg cagcactacg agcagtccaa gatgttcaat gatgccatgg acattctgaa   3900

catggtcttc accggggtgt tcaccgtcga gatggttttg aaagtcatcg catttaagcc   3960

taaggggtat tttagtgacg cctggaacac gtttgactcc ctcatcgtaa tcggcagcat   4020

tatagacgtg gccctcagcg aagcggaccc aactgaaagt gaaaatgtcc ctgtcccaac   4080

tgctacacct gggaactctg aagagagcaa tagaatctcc atcacctttt tccgtctttt   4140

ccgagtgatg cgattggtga agcttctcag caggggggaa ggcatccgga cattgctgtg   4200

gacttttatt aagtcctttc aggcgctccc gtatgtggcc ctcctcatag ccatgctgtt   4260

cttcatctat gcggtcattg gcatgcagat gtttgggaaa gttgccatga gagataacaa   4320

ccagatcaat aggaacaata acttccagac gtttccccag gcggtgctgc tgctcttcag   4380

gtgtgcaaca ggtgaggcct ggcaggagat catgctggcc tgtctcccag ggaagctctg   4440

tgaccctgag tcagattaca accccgggga ggagtataca tgtgggagca actttgccat   4500

tgtctatttc atcagttttt acatgctctg tgcatttctg atcatcaatc tgtttgtggc   4560

tgtcatcatg gataatttcg actatctgac ccgggactgg tctattttgg ggcctcacca   4620

tttagatgaa ttcaaaagaa tatggtcaga atatgaccct gaggcaaagg gaaggataaa   4680

acaccttgat gtggtcactc tgcttcgacg catccagcct cccctggggt ttgggaagtt   4740

atgtccacac agggtagcgt gcaagagatt agttgccatg aacatgcctc tcaacagtga   4800

cgggacagtc atgtttaatg caaccctgtt tgctttggtt cgaacggctc ttaagatcaa   4860

gaccgaaggg aacctggagc aagctaatga agaacttcgg gctgtgataa agaaaatttg   4920

gaagaaaacc agcatgaaat tacttgacca agttgtccct ccagctggtg atgatgaggt   4980

aaccgtgggg aagttctatg ccactttcct gatacaggac tactttagga aattcaagaa   5040

acggaaagaa caaggactgg tgggaaagta ccctgcgaag aacaccacaa ttgccctaca   5100

ggcgggatta aggacactgc atgacattgg gccagaaatc cggcgtgcta tatcgtgtga   5160

tttgcaagat gacgagcctg aggaaacaaa acgagaagaa gaagatgatg tgttcaaaag   5220

aaatggtgcc ctgcttggaa accatgtcaa tcatgttaat agtgatagga gagattccct   5280

tcagcagacc aataccaccc accgtcccct gcatgtccaa aggccttcaa ttccacctgc   5340

aagtgatact gagaaaccgc tgtttcctcc agcaggaaat tcggtgtgtc ataaccatca   5400

taaccataat tccataggaa agcaagttcc cacctcaaca aatgccaatc tcaataatgc   5460

caatatgtcc aaagctgccc atggaaagcg gcccagcatt gggaaccttg agcatgtgtc   5520

tgaaaatggg catcattctt cccacaagca tgaccgggag cctcagagaa ggtccagtgt   5580

gaaaagaacc cgctattatg aaacttacat taggtccgac tcaggagatg aacagctccc   5640

aactatttgc cgggaagacc cagagataca tggctatttc agggaccccc actgcttggg   5700

ggagcaggag tatttcagta gtgaggaatg ctacgaggat gacagctcgc ccacctggag   5760

caggcaaaac tatggctact acagcagata cccaggcaga aacatcgact ctgagaggcc   5820

ccgaggctac catcatcccc aaggattctt ggaggacgat gactcgcccg tttgctatga   5880

ttcacggaga tctccaagga gacgcctact acctcccacc ccagcatccc accggagatc   5940

ctccttcaac tttgagtgcc tgcgccggca gagcagccag gaagaggtcc cgtcgtctcc   6000

catcttcccc catcgcacgg ccctgcctct gcatctaatg cagcaacaga tcatggcagt   6060

tgccggccta gattcaagta aagcccagaa gtactcaccg agtcactcga cccggtcgtg   6120

ggccacccct ccagcaaccc ctccctaccg ggactggaca ccgtgctaca cccccctgat   6180

ccaagtggag cagtcagagg ccctggacca ggtgaacggc agcctgccgt ccctgcaccg   6240

cagctcctgg tacacagacg agcccgacat ctcctaccgg actttcacac cagccagcct   6300

gactgtcccc agcagcttcc ggaacaaaaa cagcgacaag cagaggagtg cggacagctt   6360

ggtggaggca gtcctgatat ccgaaggctt gggacgctat gcaagggacc caaaatttgt   6420

gtcagcaaca aaacacgaaa tcgctgatgc ctgtgacctc accatcgacg agatggagag   6480

tgcagccagc accctgctta atgggaacgt gcgtccccga gccaacgggg atgtgggccc   6540

cctctcacac cggcaggact atgagctaca ggactttggt cctggctaca gcgacgaaga   6600

gccagaccct gggagggatg aggaggacct ggcggatgaa atgatatgca tcaccacctt   6660

gtagccccca gcgaggggca gactggctct ggcctcaggt ggggcgcagg agagccaggg   6720

gaaaagtgcc tcatagttag gaaagtttag gcactagttg ggagtaatat tcaattaatt   6780

agacttttgt ataagagatg tcatgcctca agaaagccat aaacctggta ggaacaggtc   6840

ccaagcggtt gagcctggca gagtaccatg cgctcggccc cagctgcagg aaacagcagg   6900

ccccgccctc tcacagagga tgggtgagga ggccagacct gccctgcccc attgtccaga   6960

tgggcactgc tgtggagtct gcttctccca tgtaccaggg caccaggccc acccaactga   7020

aggcatggcg gcggggtgca ggggaaagtt aaaggtgatg acgatcatca cacctcgtgt   7080

cgttacctca gccatcggtc tagcatatca gtcactgggc ccaacatatc catttttaaa   7140

ccctttcccc caaatacact gcgtcctggt tcctgtttag ctgttctgaa ata          7193


<210>  782
<211>  2181
<212>  PRT
<213>  Homosapiens

<400>  782

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365             


Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Trp Cys Trp Trp 
                485                 490                 495     


Arg Arg Arg Gly Ala Ala Lys Ala Gly Pro Ser Gly Cys Arg Arg Trp 
            500                 505                 510         


Gly Gln Ala Ile Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp 
        515                 520                 525             


Asn Arg Phe Asn Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr 
    530                 535                 540                 


Phe Tyr Trp Leu Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile 
545                 550                 555                 560 


Ser Ser Glu His Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp 
                565                 570                 575     


Ile Ala Asn Lys Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val 
            580                 585                 590         


Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn 
        595                 600                 605             


Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu 
    610                 615                 620                 


Val Glu Leu Glu Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys 
625                 630                 635                 640 


Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu 
                645                 650                 655     


Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser 
            660                 665                 670         


Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly 
        675                 680                 685             


Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys 
    690                 695                 700                 


Arg Ser Thr Phe Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln 
705                 710                 715                 720 


Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met 
                725                 730                 735     


Ala Tyr Gly Gly Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe 
            740                 745                 750         


Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu 
        755                 760                 765             


Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala 
    770                 775                 780                 


Gln Lys Glu Glu Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys 
785                 790                 795                 800 


Glu Ser Leu Glu Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile 
                805                 810                 815     


Ala Asn Ser Asp Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp 
            820                 825                 830         


Glu Asp Lys Asp Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg 
    850                 855                 860                 


Pro Arg Arg Ile Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile 
865                 870                 875                 880 


Pro Glu Gly Ser Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg 
                885                 890                 895     


Val Gly Cys His Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile 
            900                 905                 910         


Leu Val Phe Ile Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro 
        915                 920                 925             


Ile Arg Ser His Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr 
    930                 935                 940                 


Ala Phe Thr Ala Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr 
945                 950                 955                 960 


Phe Gly Ala Phe Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn 
                965                 970                 975     


Leu Leu Asp Met Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile 
            980                 985                 990         


Gln Ser Ser Ala Ile Ser Val Val  Lys Ile Leu Arg Val  Leu Arg Val 
        995                 1000                 1005             


Leu Arg  Pro Leu Arg Ala Ile  Asn Arg Ala Lys Gly  Leu Lys His 
    1010                 1015                 1020             


Val Val  Gln Cys Val Phe Val  Ala Ile Arg Thr Ile  Gly Asn Ile 
    1025                 1030                 1035             


Met Ile  Val Thr Thr Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly 
    1040                 1045                 1050             


Val Gln  Leu Phe Lys Gly Lys  Phe Tyr Arg Cys Thr  Asp Glu Ala 
    1055                 1060                 1065             


Lys Ser  Asn Pro Glu Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys 
    1070                 1075                 1080             


Asp Gly  Asp Val Asp Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln 
    1085                 1090                 1095             


Asn Ser  Asp Phe Asn Phe Asp  Asn Val Leu Ser Ala  Met Met Ala 
    1100                 1105                 1110             


Leu Phe  Thr Val Ser Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr 
    1115                 1120                 1125             


Lys Ala  Ile Asp Ser Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn 
    1130                 1135                 1140             


His Arg  Val Glu Ile Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile 
    1145                 1150                 1155             


Val Ala  Phe Phe Met Met Asn  Ile Phe Val Gly Phe  Val Ile Val 
    1160                 1165                 1170             


Thr Phe  Gln Glu Gln Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu 
    1175                 1180                 1185             


Asp Lys  Asn Gln Arg Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg 
    1190                 1195                 1200             


Pro Leu  Arg Arg Tyr Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe 
    1205                 1210                 1215             


Trp Tyr  Val Val Asn Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val 
    1220                 1225                 1230             


Leu Ile  Met Leu Asn Thr Leu  Cys Leu Ala Met Gln  His Tyr Glu 
    1235                 1240                 1245             


Gln Ser  Lys Met Phe Asn Asp  Ala Met Asp Ile Leu  Asn Met Val 
    1250                 1255                 1260             


Phe Thr  Gly Val Phe Thr Val  Glu Met Val Leu Lys  Val Ile Ala 
    1265                 1270                 1275             


Phe Lys  Pro Lys Gly Tyr Phe  Ser Asp Ala Trp Asn  Thr Phe Asp 
    1280                 1285                 1290             


Ser Leu  Ile Val Ile Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu 
    1295                 1300                 1305             


Ala Asp  Pro Thr Glu Ser Glu  Asn Val Pro Val Pro  Thr Ala Thr 
    1310                 1315                 1320             


Pro Gly  Asn Ser Glu Glu Ser  Asn Arg Ile Ser Ile  Thr Phe Phe 
    1325                 1330                 1335             


Arg Leu  Phe Arg Val Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly 
    1340                 1345                 1350             


Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln 
    1355                 1360                 1365             


Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile 
    1370                 1375                 1380             


Tyr Ala  Val Ile Gly Met Gln  Met Phe Gly Lys Val  Ala Met Arg 
    1385                 1390                 1395             


Asp Asn  Asn Gln Ile Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro 
    1400                 1405                 1410             


Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp 
    1415                 1420                 1425             


Gln Glu  Ile Met Leu Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro 
    1430                 1435                 1440             


Glu Ser  Asp Tyr Asn Pro Gly  Glu Glu Tyr Thr Cys  Gly Ser Asn 
    1445                 1450                 1455             


Phe Ala  Ile Val Tyr Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe 
    1460                 1465                 1470             


Leu Ile  Ile Asn Leu Phe Val  Ala Val Ile Met Asp  Asn Phe Asp 
    1475                 1480                 1485             


Tyr Leu  Thr Arg Asp Trp Ser  Ile Leu Gly Pro His  His Leu Asp 
    1490                 1495                 1500             


Glu Phe  Lys Arg Ile Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly 
    1505                 1510                 1515             


Arg Ile  Lys His Leu Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln 
    1520                 1525                 1530             


Pro Pro  Leu Gly Phe Gly Lys  Leu Cys Pro His Arg  Val Ala Cys 
    1535                 1540                 1545             


Lys Arg  Leu Val Ala Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr 
    1550                 1555                 1560             


Val Met  Phe Asn Ala Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu 
    1565                 1570                 1575             


Lys Ile  Lys Thr Glu Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu 
    1580                 1585                 1590             


Arg Ala  Val Ile Lys Lys Ile  Trp Lys Lys Thr Ser  Met Lys Leu 
    1595                 1600                 1605             


Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val 
    1610                 1615                 1620             


Gly Lys  Phe Tyr Ala Thr Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys 
    1625                 1630                 1635             


Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala 
    1640                 1645                 1650             


Lys Asn  Thr Thr Ile Ala Leu  Gln Ala Gly Leu Arg  Thr Leu His 
    1655                 1660                 1665             


Asp Ile  Gly Pro Glu Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln 
    1670                 1675                 1680             


Asp Asp  Glu Pro Glu Glu Thr  Lys Arg Glu Glu Glu  Asp Asp Val 
    1685                 1690                 1695             


Phe Lys  Arg Asn Gly Ala Leu  Leu Gly Asn His Val  Asn His Val 
    1700                 1705                 1710             


Asn Ser  Asp Arg Arg Asp Ser  Leu Gln Gln Thr Asn  Thr Thr His 
    1715                 1720                 1725             


Arg Pro  Leu His Val Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp 
    1730                 1735                 1740             


Thr Glu  Lys Pro Leu Phe Pro  Pro Ala Gly Asn Ser  Val Cys His 
    1745                 1750                 1755             


Asn His  His Asn His Asn Ser  Ile Gly Lys Gln Val  Pro Thr Ser 
    1760                 1765                 1770             


Thr Asn  Ala Asn Leu Asn Asn  Ala Asn Met Ser Lys  Ala Ala His 
    1775                 1780                 1785             


Gly Lys  Arg Pro Ser Ile Gly  Asn Leu Glu His Val  Ser Glu Asn 
    1790                 1795                 1800             


Gly His  His Ser Ser His Lys  His Asp Arg Glu Pro  Gln Arg Arg 
    1805                 1810                 1815             


Ser Ser  Val Lys Arg Thr Arg  Tyr Tyr Glu Thr Tyr  Ile Arg Ser 
    1820                 1825                 1830             


Asp Ser  Gly Asp Glu Gln Leu  Pro Thr Ile Cys Arg  Glu Asp Pro 
    1835                 1840                 1845             


Glu Ile  His Gly Tyr Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln 
    1850                 1855                 1860             


Glu Tyr  Phe Ser Ser Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro 
    1865                 1870                 1875             


Thr Trp  Ser Arg Gln Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly 
    1880                 1885                 1890             


Arg Asn  Ile Asp Ser Glu Arg  Pro Arg Gly Tyr His  His Pro Gln 
    1895                 1900                 1905             


Gly Phe  Leu Glu Asp Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg 
    1910                 1915                 1920             


Arg Ser  Pro Arg Arg Arg Leu  Leu Pro Pro Thr Pro  Ala Ser His 
    1925                 1930                 1935             


Arg Arg  Ser Ser Phe Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser 
    1940                 1945                 1950             


Gln Glu  Glu Val Pro Ser Ser  Pro Ile Phe Pro His  Arg Thr Ala 
    1955                 1960                 1965             


Leu Pro  Leu His Leu Met Gln  Gln Gln Ile Met Ala  Val Ala Gly 
    1970                 1975                 1980             


Leu Asp  Ser Ser Lys Ala Gln  Lys Tyr Ser Pro Ser  His Ser Thr 
    1985                 1990                 1995             


Arg Ser  Trp Ala Thr Pro Pro  Ala Thr Pro Pro Tyr  Arg Asp Trp 
    2000                 2005                 2010             


Thr Pro  Cys Tyr Thr Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala 
    2015                 2020                 2025             


Leu Asp  Gln Val Asn Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser 
    2030                 2035                 2040             


Trp Tyr  Thr Asp Glu Pro Asp  Ile Ser Tyr Arg Thr  Phe Thr Pro 
    2045                 2050                 2055             


Ala Ser  Leu Thr Val Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp 
    2060                 2065                 2070             


Lys Gln  Arg Ser Ala Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2075                 2080                 2085             


Glu Gly  Leu Gly Arg Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala 
    2090                 2095                 2100             


Thr Lys  His Glu Ile Ala Asp  Ala Cys Asp Leu Thr  Ile Asp Glu 
    2105                 2110                 2115             


Met Glu  Ser Ala Ala Ser Thr  Leu Leu Asn Gly Asn  Val Arg Pro 
    2120                 2125                 2130             


Arg Ala  Asn Gly Asp Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr 
    2135                 2140                 2145             


Glu Leu  Gln Asp Phe Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp 
    2150                 2155                 2160             


Pro Gly  Arg Asp Glu Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile 
    2165                 2170                 2175             


Thr Thr  Leu 
    2180     


<210>  783
<211>  2162
<212>  DNA
<213>  Homosapiens

<400>  783
agcgggccgc ggccacccgc tcctcccgct ccggtcccga ctgtcgggct ctcggccgag     60

tcgccccgga caatcacaaa gagtgtgtag gccagccccg gtcacagagt gcaccgtatc    120

ctgtcacttc tggatgtgag ggagaagtga gtcatctcat tcccctccgt ggatcagagg    180

acttggacta gatagaagca tgtggtgtct cctacgaggc ctgggccggc ctggagccct    240

ggcacgggga gccctggggc agcagcaatc cctgggtgcc cgggccctgg ccagcgcagg    300

ctctgagagc cgggacgagt acagctatgt ggtggtgggc gcgggctcgg cgggctgcgt    360

gctggctggg aggctcacgg aggaccccgc cgagcgcgtg ctgctgctgg aggccgggcc    420

caaggacgtg cgcgcgggga gcaagcggct ctcgtggaag atccacatgc ccgcggccct    480

ggtggccaac ctgtgcgacg acaggtacaa ctggtgctac cacacagagg tgcagcgggg    540

cctggacggc cgcgtgctgt actggccacg cggccgcgtc tggggtggct cctcatccct    600

caatgccatg gtctacgtcc gtgggcacgc cgaggactac gagcgctggc agcgccaggg    660

cgcccgcggc tgggactacg cgcactgcct gccctacttc cgcaaggcgc agggccacga    720

gctgggcgcc agccggtacc ggggcgccga tggcccgctg cgggtgtccc ggggcaagac    780

caaccacccg ctgcactgcg cattcctgga ggccacgcag caggccggct acccgctcac    840

cgaggacatg aatggcttcc agcaggaggg cttcggctgg atggacatga ccatccatga    900

aggcaaacgg tggagcgcag cctgtgccta cctgcaccca gcactgagcc gcaccaacct    960

caaggccgag gccgagacgc ttgtgagcag ggtgctattt gagggcaccc gtgcagtggg   1020

cgtggagtat gtcaagaatg gccagagcca cagggcttat gccagcaagg aggtgattct   1080

gagtggaggt gccatcaact ctccacagct gctcatgctc tctggcatcg ggaatgctga   1140

tgacctcaag aaactgggca tccctgtggt gtgccaccta cctggggttg gccagaacct   1200

gcaagaccac ctggagatct acattcagca ggcatgcacc cgccctatca ccctccattc   1260

agcacagaag cccctgcgga aggtctgcat tggtctggag tggctctgga aattcacagg   1320

ggagggagcc actgcccatc tggaaacagg tgggttcatc cgcagccagc ctggggtccc   1380

ccacccggac atccagttcc atttcctgcc atcccaagtg attgaccacg ggcgggtccc   1440

cacccagcag gaggcttacc aggtacatgt ggggcccatg cggggcacga gtgtgggctg   1500

gctcaaactg agaagtgcca atccccaaga ccaccctgtg atccagccca actacttgtc   1560

aacagaaact gatattgagg atttccgtct gtgtgtgaag ctcaccagag aaatttttgc   1620

acaggaagcc ctggctccgt tccgagggaa agagctccag ccaggaagcc acattcagtc   1680

agataaagag atagatgcct ttgtgcgggc aaaagccgac agcgcctacc acccctcgtg   1740

cacctgtaag atgggccagc cctccgatcc cactgccgtg gtggatccgc agacaagggt   1800

cctcggggtg gaaaacctca gggtcgtcga tgcctccatc atgcctagca tggtcagcgg   1860

caacctgaac gcccccacaa tcatgatcgc agagaaggca gctgacatta tcaaggggca   1920

gcctgcactc tgggacaaag atgtccctgt ctacaagccc aggacgctgg ccacccagcg   1980

ctaagacagt tgctgctgga ggatgaccag ggaagccccc tgataagcca agagggccag   2040

cacagccctt gctcccaggc tcctgcctga aactatctag cacactagga cccaggtggt   2100

accctactca gtggctgaga attggataaa gtcttgggaa atgagacaaa aaaaaaaaaa   2160

aa                                                                  2162


<210>  784
<211>  594
<212>  PRT
<213>  Homosapiens

<400>  784

Met Trp Cys Leu Leu Arg Gly Leu Gly Arg Pro Gly Ala Leu Ala Arg 
1               5                   10                  15      


Gly Ala Leu Gly Gln Gln Gln Ser Leu Gly Ala Arg Ala Leu Ala Ser 
            20                  25                  30          


Ala Gly Ser Glu Ser Arg Asp Glu Tyr Ser Tyr Val Val Val Gly Ala 
        35                  40                  45              


Gly Ser Ala Gly Cys Val Leu Ala Gly Arg Leu Thr Glu Asp Pro Ala 
    50                  55                  60                  


Glu Arg Val Leu Leu Leu Glu Ala Gly Pro Lys Asp Val Arg Ala Gly 
65                  70                  75                  80  


Ser Lys Arg Leu Ser Trp Lys Ile His Met Pro Ala Ala Leu Val Ala 
                85                  90                  95      


Asn Leu Cys Asp Asp Arg Tyr Asn Trp Cys Tyr His Thr Glu Val Gln 
            100                 105                 110         


Arg Gly Leu Asp Gly Arg Val Leu Tyr Trp Pro Arg Gly Arg Val Trp 
        115                 120                 125             


Gly Gly Ser Ser Ser Leu Asn Ala Met Val Tyr Val Arg Gly His Ala 
    130                 135                 140                 


Glu Asp Tyr Glu Arg Trp Gln Arg Gln Gly Ala Arg Gly Trp Asp Tyr 
145                 150                 155                 160 


Ala His Cys Leu Pro Tyr Phe Arg Lys Ala Gln Gly His Glu Leu Gly 
                165                 170                 175     


Ala Ser Arg Tyr Arg Gly Ala Asp Gly Pro Leu Arg Val Ser Arg Gly 
            180                 185                 190         


Lys Thr Asn His Pro Leu His Cys Ala Phe Leu Glu Ala Thr Gln Gln 
        195                 200                 205             


Ala Gly Tyr Pro Leu Thr Glu Asp Met Asn Gly Phe Gln Gln Glu Gly 
    210                 215                 220                 


Phe Gly Trp Met Asp Met Thr Ile His Glu Gly Lys Arg Trp Ser Ala 
225                 230                 235                 240 


Ala Cys Ala Tyr Leu His Pro Ala Leu Ser Arg Thr Asn Leu Lys Ala 
                245                 250                 255     


Glu Ala Glu Thr Leu Val Ser Arg Val Leu Phe Glu Gly Thr Arg Ala 
            260                 265                 270         


Val Gly Val Glu Tyr Val Lys Asn Gly Gln Ser His Arg Ala Tyr Ala 
        275                 280                 285             


Ser Lys Glu Val Ile Leu Ser Gly Gly Ala Ile Asn Ser Pro Gln Leu 
    290                 295                 300                 


Leu Met Leu Ser Gly Ile Gly Asn Ala Asp Asp Leu Lys Lys Leu Gly 
305                 310                 315                 320 


Ile Pro Val Val Cys His Leu Pro Gly Val Gly Gln Asn Leu Gln Asp 
                325                 330                 335     


His Leu Glu Ile Tyr Ile Gln Gln Ala Cys Thr Arg Pro Ile Thr Leu 
            340                 345                 350         


His Ser Ala Gln Lys Pro Leu Arg Lys Val Cys Ile Gly Leu Glu Trp 
        355                 360                 365             


Leu Trp Lys Phe Thr Gly Glu Gly Ala Thr Ala His Leu Glu Thr Gly 
    370                 375                 380                 


Gly Phe Ile Arg Ser Gln Pro Gly Val Pro His Pro Asp Ile Gln Phe 
385                 390                 395                 400 


His Phe Leu Pro Ser Gln Val Ile Asp His Gly Arg Val Pro Thr Gln 
                405                 410                 415     


Gln Glu Ala Tyr Gln Val His Val Gly Pro Met Arg Gly Thr Ser Val 
            420                 425                 430         


Gly Trp Leu Lys Leu Arg Ser Ala Asn Pro Gln Asp His Pro Val Ile 
        435                 440                 445             


Gln Pro Asn Tyr Leu Ser Thr Glu Thr Asp Ile Glu Asp Phe Arg Leu 
    450                 455                 460                 


Cys Val Lys Leu Thr Arg Glu Ile Phe Ala Gln Glu Ala Leu Ala Pro 
465                 470                 475                 480 


Phe Arg Gly Lys Glu Leu Gln Pro Gly Ser His Ile Gln Ser Asp Lys 
                485                 490                 495     


Glu Ile Asp Ala Phe Val Arg Ala Lys Ala Asp Ser Ala Tyr His Pro 
            500                 505                 510         


Ser Cys Thr Cys Lys Met Gly Gln Pro Ser Asp Pro Thr Ala Val Val 
        515                 520                 525             


Asp Pro Gln Thr Arg Val Leu Gly Val Glu Asn Leu Arg Val Val Asp 
    530                 535                 540                 


Ala Ser Ile Met Pro Ser Met Val Ser Gly Asn Leu Asn Ala Pro Thr 
545                 550                 555                 560 


Ile Met Ile Ala Glu Lys Ala Ala Asp Ile Ile Lys Gly Gln Pro Ala 
                565                 570                 575     


Leu Trp Asp Lys Asp Val Pro Val Tyr Lys Pro Arg Thr Leu Ala Thr 
            580                 585                 590         


Gln Arg 
        


<210>  785
<211>  2077
<212>  DNA
<213>  Homosapiens

<400>  785
agcgcagcgt gcgggtggcc tggatcccgc gcagtggccc ggcgatgtcg ctcgtgctgc     60

taagcctggc cgcgctgtgc aggagcgccg taccccgaga gccgaccgtt caatgtggct    120

ctgaaactgg gccatctcca gagtggatgc tacaacatga tctaatcccc ggagacttga    180

gggacctccg agtagaacct gttacaacta gtgttgcaac aggggactat tcaattttga    240

tgaatgtaag ctgggtactc cgggcagatg ccagcatccg cttgttgaag gccaccaaga    300

tttgtgtgac gggcaaaagc aacttccagt cctacagctg tgtgaggtgc aattacacag    360

aggccttcca gactcagacc agaccctctg gtggtaaatg gacattttcc tacatcggct    420

tccctgtaga gctgaacaca gtctatttca ttggggccca taatattcct aatgcaaata    480

tgaatgaaga tggcccttcc atgtctgtga atttcacctc accaggctgc ctagaccaca    540

taatgaaata taaaaaaaag tgtgtcaagg ccggaagcct gtgggatccg aacatcactg    600

cttgtaagaa gaatgaggag acagtagaag tgaacttcac aaccactccc ctgggaaaca    660

gatacatggc tcttatccaa cacagcacta tcatcgggtt ttctcaggtg tttgagccac    720

accagaagaa acaaacgcga gcttcagtgg tgattccagt gactggggat agtgaaggtg    780

ctacggtgca gctgactcca tattttccta cttgtggcag cgactgcatc cgacataaag    840

gaacagttgt gctctgccca caaacaggcg tccctttccc tctggataac aacaaaagca    900

agccgggagg ctggctgcct ctcctcctgc tgtctctgct ggtggccaca tgggtgctgg    960

tggcagggat ctatctaatg tggaggcacg aaaggatcaa gaagacttcc ttttctacca   1020

ccacactact gccccccatt aaggttcttg tggtttaccc atctgaaata tgtttccatc   1080

acacaatttg ttacttcact gaatttcttc aaaaccattg cagaagtgag gtcatccttg   1140

aaaagtggca gaaaaagaaa atagcagaga tgggtccagt gcagtggctt gccactcaaa   1200

agaaggcagc agacaaagtc gtcttccttc tttccaatga cgtcaacagt gtgtgcgatg   1260

gtacctgtgg caagagcgag ggcagtccca gtgagaactc tcaagacctc ttcccccttg   1320

cctttaacct tttctgcagt gatctaagaa gccagattca tctgcacaaa tacgtggtgg   1380

tctactttag agagattgat acaaaagacg attacaatgc tctcagtgtc tgccccaagt   1440

accacctcat gaaggatgcc actgctttct gtgcagaact tctccatgtc aagcagcagg   1500

tgtcagcagg aaaaagatca caagcctgcc acgatggctg ctgctccttg tagcccaccc   1560

atgagaagca agagacctta aaggcttcct atcccaccaa ttacagggaa aaaacgtgtg   1620

atgatcctga agcttactat gcagcctaca aacagcctta gtaattaaaa cattttatac   1680

caataaaatt ttcaaatatt gctaactaat gtagcattaa ctaacgattg gaaactacat   1740

ttacaacttc aaagctgttt tatacataga aatcaattac agttttaatt gaaaactata   1800

accattttga taatgcaaca ataaagcatc ttcagccaaa catctagtct tccatagacc   1860

atgcattgca gtgtacccag aactgtttag ctaatattct atgtttaatt aatgaatact   1920

aactctaaga acccctcact gattcactca atagcatctt aagtgaaaaa ccttctatta   1980

catgcaaaaa atcattgttt ttaagataac aaaagtaggg aataaacaag ctgaacccac   2040

ttttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                            2077


<210>  786
<211>  502
<212>  PRT
<213>  Homosapiens

<400>  786

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  787
<211>  3105
<212>  DNA
<213>  Homosapiens

<400>  787
agcgcagcgt gcgggtggcc tggatcccgc gcagtggccc ggcgatgtcg ctcgtgctgc     60

taagcctggc cgcgctgtgc aggagcgccg taccccgaga gccgaccgtt caatgtggct    120

ctgaaactgg gccatctcca gagtggatgc tacaacatga tctaatcccc ggagacttga    180

gggacctccg agtagaacct gttacaacta gtgttgcaac aggggactat tcaattttga    240

tgaatgtaag ctgggtactc cgggcagatg ccagcatccg cttgttgaag gccaccaaga    300

tttgtgtgac gggcaaaagc aacttccagt cctacagctg tgtgaggtgc aattacacag    360

aggccttcca gactcagacc agaccctctg gtggtaaatg gacattttcc tacatcggct    420

tccctgtaga gctgaacaca gtctatttca ttggggccca taatattcct aatgcaaata    480

tgaatgaaga tggcccttcc atgtctgtga atttcacctc accaggctgc ctagaccaca    540

taatgaaata taaaaaaaag tgtgtcaagg ccggaagcct gtgggatccg aacatcactg    600

cttgtaagaa gaatgaggag acagtagaag tgaacttcac aaccactccc ctgggaaaca    660

gatacatggc tcttatccaa cacagcacta tcatcgggtt ttctcaggtg tttgagccac    720

accagaagaa acaaacgcga gcttcagtgg tgattccagt gactggggat agtgaaggtg    780

ctacggtgca ggtaaagttc agtgagctgc tctggggagg gaagggacat agaagactgt    840

tccatcattc attgctttta aggatgagtt ctctcttgtc aaatgcactt ctgccagcag    900

acaccagtta agtggcgttc atgggggctc tttcgctgca gcctccaccg tgctgaggtc    960

aggaggccga cgtggcagtt gtggtccctt ttgcttgtat taatggctgc tgaccttcca   1020

aagcactttt tattttcatt ttctgtcaca gacactcagg gatagcagta ccattttact   1080

tccgcaagcc tttaactgca agatgaagct gcaaagggtt tgaaatggga aggtttgagt   1140

tccaggcagc gtatgaactc tggagagggg ctgccagtcc tctctgggcc gcagcggacc   1200

cagctggaac acaggaagtt ggagcagtag gtgctccttc acctctcagt atgtctcttt   1260

caactctagt ttttgaggtg gggacacagg aggtccagtg ggacacagcc actccccaaa   1320

gagtaaggag cttccatgct tcattccctg gcataaaaag tgctcaaaca caccagaggg   1380

ggcaggcacc agccagggta tgatggctac tacccttttc tggagaacca tagacttccc   1440

ttactacagg gacttgcatg tcctaaagca ctggctgaag gaagccaaga ggatcactgc   1500

tgctcctttt ttctagagga aatgtttgtc tacgtggtaa gatatgacct agccctttta   1560

ggtaagcgaa ctggtatgtt agtaacgtgt acaaagttta ggttcagacc ccgggagtct   1620

tgggcacgtg ggtctcgggt cactggtttt gactttaggg ctttgttaca gatgtgtgac   1680

caaggggaaa atgtgcatga caacactaga ggtatgggcg aagccagaaa gaagggaagt   1740

tttggctgaa gtaggagtct tggtgagatt ttgctctgat gcatggtgtg aactttctga   1800

gcctcttgtt tttcctcagc tgactccata ttttcctact tgtggcagcg actgcatccg   1860

acataaagga acagttgtgc tctgcccaca aacaggcgtc cctttccctc tggataacaa   1920

caaaagcaag ccgggaggct ggctgcctct cctcctgctg tctctgctgg tggccacatg   1980

ggtgctggtg gcagggatct atctaatgtg gaggcacgaa aggatcaaga agacttcctt   2040

ttctaccacc acactactgc cccccattaa ggttcttgtg gtttacccat ctgaaatatg   2100

tttccatcac acaatttgtt acttcactga atttcttcaa aaccattgca gaagtgaggt   2160

catccttgaa aagtggcaga aaaagaaaat agcagagatg ggtccagtgc agtggcttgc   2220

cactcaaaag aaggcagcag acaaagtcgt cttccttctt tccaatgacg tcaacagtgt   2280

gtgcgatggt acctgtggca agagcgaggg cagtcccagt gagaactctc aagacctctt   2340

cccccttgcc tttaaccttt tctgcagtga tctaagaagc cagattcatc tgcacaaata   2400

cgtggtggtc tactttagag agattgatac aaaagacgat tacaatgctc tcagtgtctg   2460

ccccaagtac cacctcatga aggatgccac tgctttctgt gcagaacttc tccatgtcaa   2520

gcagcaggtg tcagcaggaa aaagatcaca agcctgccac gatggctgct gctccttgta   2580

gcccacccat gagaagcaag agaccttaaa ggcttcctat cccaccaatt acagggaaaa   2640

aacgtgtgat gatcctgaag cttactatgc agcctacaaa cagccttagt aattaaaaca   2700

ttttatacca ataaaatttt caaatattgc taactaatgt agcattaact aacgattgga   2760

aactacattt acaacttcaa agctgtttta tacatagaaa tcaattacag ttttaattga   2820

aaactataac cattttgata atgcaacaat aaagcatctt cagccaaaca tctagtcttc   2880

catagaccat gcattgcagt gtacccagaa ctgtttagct aatattctat gtttaattaa   2940

tgaatactaa ctctaagaac ccctcactga ttcactcaat agcatcttaa gtgaaaaacc   3000

ttctattaca tgcaaaaaat cattgttttt aagataacaa aagtagggaa taaacaagct   3060

gaacccactt ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                   3105


<210>  788
<211>  288
<212>  PRT
<213>  Homosapiens

<400>  788

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Val Lys Phe Ser Glu Leu Leu 
                245                 250                 255     


Trp Gly Gly Lys Gly His Arg Arg Leu Phe His His Ser Leu Leu Leu 
            260                 265                 270         


Arg Met Ser Ser Leu Leu Ser Asn Ala Leu Leu Pro Ala Asp Thr Ser 
        275                 280                 285             


<210>  789
<211>  3525
<212>  DNA
<213>  Homosapiens

<400>  789
atcccggcag tcgtggctgc agcgctgagg cgagaggttg gtgggtgtct ccggccataa     60

tgacccaggc tgagaagggt gatacggaga acggaaagga gaagggcggc gagaaggaga    120

aggagcagcg cggcgtgaag cggcccatcg tgcccgcgct ggtgccggag tcgctgcaag    180

agcaaatcca gagcaacttc atcattgtca tacatccagg ttcaacaact ttaaggattg    240

gtcgagccac agacactctt cctgccagca ttcctcacgt cattgcccga agacacaaac    300

aacaagggca gcccctatac aaggacagtt ggctcctaag ggagggacta aataaaccag    360

aaagtaatga acaaagacaa aatggcctta aaatggtgga tcaagcaata tggtctaaaa    420

agatgtccaa tggtacaaga cgcattcctg tgtcccctga acaggcacgc tcctacaata    480

agcagatgcg acctgcaatt ttagatcact gttcgggaaa taagtggaca aacacatctc    540

atcaccctga gtatttagta ggagaagagg ccttgtatgt taatccactg gactgttaca    600

atattcactg gcctatcaga agaggtcagt taaatattca cccaggccct gggggctctc    660

ttacagctgt tctggcagat attgaagtaa tatggtctca tgcgatacaa aaatacttgg    720

aaatcccact gaaagattta aagtattata gatgtatctt gttaattcct gatatctata    780

ataagcagca tgtgaaagaa ctagtgaata tgatactaat gaagatgggt ttttcaggga    840

ttgtggtcca tcaggagtct gtgtgtgcca cctatggaag tggcttaagc agcacgtgta    900

ttgtagacgt tggggaccag aagacaagtg tatgctgtgt ggaggatggg gtgtctcatc    960

ggaatactcg gctttgtctg gcatacggag gatctgatgt gtcaagatgt ttttactggc   1020

taatgcagcg agctgggttc ccttacagag aatgccagtt aacaaataaa atggattgtc   1080

ttcttctgca acaccttaaa gaaacttttt gtcatttaga tcaggacatc tctgggcttc   1140

aggaccatga gtttcagatt cgacatcctg attctcctgc cctgctttac cagtttcgat   1200

taggagatga aaaactgcag gctccaatgg ctttgtttta ccccgcaact tttggaatcg   1260

ttggacagaa aatgacgact ttgcagcaca gatctcaggg cgatcctgag gatcctcacg   1320

atgaacatta cctgctggcc acacagagca aacaagaaca gtctgcaaaa gctactgctg   1380

accgaaagtc tgcatccaaa cctattggat ttgaagggga tcttcgtggc cagtcctctg   1440

atcttccaga aagactccat tcccaggagg tagatttggg gtctgcacag ggagatggcc   1500

tgatggccgg caacgattcc gaggaggccc tcactgcact gatgtccagg aagactgcca   1560

tctcgctgtt tgaaggaaaa gccctgggcc tggataaagc catcctccat agcatagact   1620

gctgttcatc tgacgacacc aaaaagaaga tgtacagctc catcctagtg gtgggaggtg   1680

gtttgatgtt tcataaagct caagaatttc tgcagcacag aattctcaac aaaatgccac   1740

catccttcag gcgaattatt gaaaatgtgg atgtgatcac aaggcctaag gacatggacc   1800

cccggctgat tgcatggaaa ggaggggcag tgttggcttg tttggataca acacaggaac   1860

tgtggattta tcagcgagag tggcagcgct ttggtgtccg catgttacga gagcgggctg   1920

cgtttgtgtg gtgaatgggg aggaaatgtc actgccgaag accaaaaaca agcttcttgg   1980

tataaaagac tcttacagaa tatgtgtatt gtaatttatt gatctggatg cttaagtgtc   2040

atggacagta aatgaatttg aactttatgt tgaggacatg acattggttt gaaaatataa   2100

actgcttttg agcagtttag tcagggcatt tgagaataaa taggaacttt ctcttcagtt   2160

gtaaactctc ttgccctctc tcagggtctc ataaactccc cagtgatgta aacgttgcta   2220

ttgaaggttc tcatgtggtg aagcccttca tttaagttgg cttgaatctc atcagcaggc   2280

agcctcatgc aaccatgagg gatagtatgt gacgagggag aactgtccac tcatgccatt   2340

ttctctcttg tctagtattt cattaggatc taaagttgtc tgagttaaat gcacttatgt   2400

gactcatgtg tcctcttaga atcccaaata gggggaaaaa gttttggtgg tttttgtttt   2460

ttttttcatt ttctgttgga ttacagaaaa agaatgggac ccattcaggt ctcgatttcc   2520

aaaggtaaag atggaaggct gggcagactg gcttttgtta cctgacatgc cgtagggtga   2580

gcttagagga agaaagaaaa caatttttat ttggccaaaa cagaacaaat gctgaaaagg   2640

aaatcttgtt tttttcctaa agccaaatag aaatgatttg ggtataattt aagagtcctt   2700

gtgttgtaca gatatggtga ctgatgtagt tattaatact accaacttag tcatcaagcc   2760

tcaattttcc tttacctgaa ggattaagtg aaagcttttg gagttcatga tgttcagtat   2820

gatcagttaa ccttaacctc tgagcatcct gaagcaaaat ctaaataatg cagctattac   2880

cactggtggt ccaggctctg gtgaagccct ctgagcccag gaggaagaga aagcattgtc   2940

cagaggtagg aacacagtct gggagcccag agctctggga ggagtgggaa aatgctgctt   3000

cctgctgctt gcttctaggc acctgcttcc gccatctcac ttaccatggc tagagatggg   3060

ggtgagactg gggaaggaca aaagcaggga acagataagg gatggaaatc agaagggaat   3120

atagaaagaa ctctggatgt ggagaaatgc cggtacctga gcattttgta tcaatgggag   3180

taccctctgt aactgctcag taggttacaa atgaagagtc caccagtatt agaaacaatt   3240

taaacttgcc agtaccaact gggatgtgtg ccttcaattt gaaaattgta tgttttattt   3300

tttaaatttg ttaacagcat taatttatag agtattgatg tcatttatgt ttctgaggtg   3360

tttcaacaca attttggatc agctgcctgt ttgcaaaaac ataatatatt tctgttaaac   3420

agttcttcac ctaacagcat attgctctta taactggtag agctgtttca aaggaagttg   3480

gtttctggtc caagttttga cctaaaccat gtccatcttc tatta                   3525


<210>  790
<211>  624
<212>  PRT
<213>  Homosapiens

<400>  790

Met Thr Gln Ala Glu Lys Gly Asp Thr Glu Asn Gly Lys Glu Lys Gly 
1               5                   10                  15      


Gly Glu Lys Glu Lys Glu Gln Arg Gly Val Lys Arg Pro Ile Val Pro 
            20                  25                  30          


Ala Leu Val Pro Glu Ser Leu Gln Glu Gln Ile Gln Ser Asn Phe Ile 
        35                  40                  45              


Ile Val Ile His Pro Gly Ser Thr Thr Leu Arg Ile Gly Arg Ala Thr 
    50                  55                  60                  


Asp Thr Leu Pro Ala Ser Ile Pro His Val Ile Ala Arg Arg His Lys 
65                  70                  75                  80  


Gln Gln Gly Gln Pro Leu Tyr Lys Asp Ser Trp Leu Leu Arg Glu Gly 
                85                  90                  95      


Leu Asn Lys Pro Glu Ser Asn Glu Gln Arg Gln Asn Gly Leu Lys Met 
            100                 105                 110         


Val Asp Gln Ala Ile Trp Ser Lys Lys Met Ser Asn Gly Thr Arg Arg 
        115                 120                 125             


Ile Pro Val Ser Pro Glu Gln Ala Arg Ser Tyr Asn Lys Gln Met Arg 
    130                 135                 140                 


Pro Ala Ile Leu Asp His Cys Ser Gly Asn Lys Trp Thr Asn Thr Ser 
145                 150                 155                 160 


His His Pro Glu Tyr Leu Val Gly Glu Glu Ala Leu Tyr Val Asn Pro 
                165                 170                 175     


Leu Asp Cys Tyr Asn Ile His Trp Pro Ile Arg Arg Gly Gln Leu Asn 
            180                 185                 190         


Ile His Pro Gly Pro Gly Gly Ser Leu Thr Ala Val Leu Ala Asp Ile 
        195                 200                 205             


Glu Val Ile Trp Ser His Ala Ile Gln Lys Tyr Leu Glu Ile Pro Leu 
    210                 215                 220                 


Lys Asp Leu Lys Tyr Tyr Arg Cys Ile Leu Leu Ile Pro Asp Ile Tyr 
225                 230                 235                 240 


Asn Lys Gln His Val Lys Glu Leu Val Asn Met Ile Leu Met Lys Met 
                245                 250                 255     


Gly Phe Ser Gly Ile Val Val His Gln Glu Ser Val Cys Ala Thr Tyr 
            260                 265                 270         


Gly Ser Gly Leu Ser Ser Thr Cys Ile Val Asp Val Gly Asp Gln Lys 
        275                 280                 285             


Thr Ser Val Cys Cys Val Glu Asp Gly Val Ser His Arg Asn Thr Arg 
    290                 295                 300                 


Leu Cys Leu Ala Tyr Gly Gly Ser Asp Val Ser Arg Cys Phe Tyr Trp 
305                 310                 315                 320 


Leu Met Gln Arg Ala Gly Phe Pro Tyr Arg Glu Cys Gln Leu Thr Asn 
                325                 330                 335     


Lys Met Asp Cys Leu Leu Leu Gln His Leu Lys Glu Thr Phe Cys His 
            340                 345                 350         


Leu Asp Gln Asp Ile Ser Gly Leu Gln Asp His Glu Phe Gln Ile Arg 
        355                 360                 365             


His Pro Asp Ser Pro Ala Leu Leu Tyr Gln Phe Arg Leu Gly Asp Glu 
    370                 375                 380                 


Lys Leu Gln Ala Pro Met Ala Leu Phe Tyr Pro Ala Thr Phe Gly Ile 
385                 390                 395                 400 


Val Gly Gln Lys Met Thr Thr Leu Gln His Arg Ser Gln Gly Asp Pro 
                405                 410                 415     


Glu Asp Pro His Asp Glu His Tyr Leu Leu Ala Thr Gln Ser Lys Gln 
            420                 425                 430         


Glu Gln Ser Ala Lys Ala Thr Ala Asp Arg Lys Ser Ala Ser Lys Pro 
        435                 440                 445             


Ile Gly Phe Glu Gly Asp Leu Arg Gly Gln Ser Ser Asp Leu Pro Glu 
    450                 455                 460                 


Arg Leu His Ser Gln Glu Val Asp Leu Gly Ser Ala Gln Gly Asp Gly 
465                 470                 475                 480 


Leu Met Ala Gly Asn Asp Ser Glu Glu Ala Leu Thr Ala Leu Met Ser 
                485                 490                 495     


Arg Lys Thr Ala Ile Ser Leu Phe Glu Gly Lys Ala Leu Gly Leu Asp 
            500                 505                 510         


Lys Ala Ile Leu His Ser Ile Asp Cys Cys Ser Ser Asp Asp Thr Lys 
        515                 520                 525             


Lys Lys Met Tyr Ser Ser Ile Leu Val Val Gly Gly Gly Leu Met Phe 
    530                 535                 540                 


His Lys Ala Gln Glu Phe Leu Gln His Arg Ile Leu Asn Lys Met Pro 
545                 550                 555                 560 


Pro Ser Phe Arg Arg Ile Ile Glu Asn Val Asp Val Ile Thr Arg Pro 
                565                 570                 575     


Lys Asp Met Asp Pro Arg Leu Ile Ala Trp Lys Gly Gly Ala Val Leu 
            580                 585                 590         


Ala Cys Leu Asp Thr Thr Gln Glu Leu Trp Ile Tyr Gln Arg Glu Trp 
        595                 600                 605             


Gln Arg Phe Gly Val Arg Met Leu Arg Glu Arg Ala Ala Phe Val Trp 
    610                 615                 620                 


<210>  791
<211>  832
<212>  DNA
<213>  Homosapiens

<400>  791
cgcccgtcgg gggcgcgtct ctttcagcag ccaatgggct ctgcccacct tcgtcctcgt     60

cagcattttg tctaatcgcg gcctgtgacg ctcgaagggc ggggagcaga gggagataca    120

gaaaccgaca ggggccaggc gcccggtggc tccgaagcgg ggaagtggga caagatggtt    180

tacatctcga acggacaagt gttggacagc cggagtcagt ctccatggag attatctttg    240

ataacagatt tcttctgggg aatagctgag tttgtggttt tgtttttcaa aactctgctt    300

cagcaagatg tgaaaaaaag aagaagctat ggaaactcat ctgattccag atatgatgat    360

ggaagagggc caccaggaaa ccctccccga agaatgggta gaatcaatca tctgcgtggc    420

cctagtcccc ctccaatggc tggtggatga ggaaggtaaa tgtctgctct aagaagcaga    480

caaccggaca tgcgcattca tagcagaagg aaaccatcaa gaagtggaag gctgaccatg    540

atgagcagta gatgaatgtg tatgtctaaa caaggactgc tctgtgtcct cacagatgaa    600

tgaggtcatg ctgggaattc cctctgcagg gaactggcct gactgacatg cagttccata    660

aatgcagatg tttgtctcat tacctttttg tatagtttat taaagtatta atatagtttt    720

aataagtaaa tatttttagg ttgcagaatg gactcctcat ctttatattc acgaaaaagc    780

aatctgaaga aaacaaataa aagcctgtgt atttagcaaa aaaaaaaaaa aa            832


<210>  792
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  792

Met Val Tyr Ile Ser Asn Gly Gln Val Leu Asp Ser Arg Ser Gln Ser 
1               5                   10                  15      


Pro Trp Arg Leu Ser Leu Ile Thr Asp Phe Phe Trp Gly Ile Ala Glu 
            20                  25                  30          


Phe Val Val Leu Phe Phe Lys Thr Leu Leu Gln Gln Asp Val Lys Lys 
        35                  40                  45              


Arg Arg Ser Tyr Gly Asn Ser Ser Asp Ser Arg Tyr Asp Asp Gly Arg 
    50                  55                  60                  


Gly Pro Pro Gly Asn Pro Pro Arg Arg Met Gly Arg Ile Asn His Leu 
65                  70                  75                  80  


Arg Gly Pro Ser Pro Pro Pro Met Ala Gly Gly Gly Arg 
                85                  90              


<210>  793
<211>  3689
<212>  DNA
<213>  Homosapiens

<400>  793
cggccgctct cgtcgccgcc gcagcgggcg cgtcggaggg agcccagcat ggccgggccg     60

ggctcgccgc gccgcgcgtc ccggggggcc tcggcgcttc tcgctgccgc gcttctctac    120

gccgcgctgg gggacgtggt gcgctcggag cagcagatac cgctctccgt ggtgaagctc    180

tgggcctcgg cttttggtgg ggagataaaa tccattgctg ctaagtactc cggttcccag    240

cttctgcaaa agaaatacaa agagtatgag aaagacgttg ccatagaaga aatcgatggc    300

ctccaactgg taaagaagct ggcaaagaac atggaagaga tgtttcacaa gaagtctgag    360

gccgtcaggc gtctggtgga ggctgcagaa gaagcacacc tgaaacatga atttgatgca    420

gacttacagt atgaatactt caatgctgtg ctgataaatg aaagggacaa agacgggaat    480

tttttggagc tgggaaagga attcatctta gccccaaatg accattttaa taatttgcct    540

gtgaacatca gtctaagtga cgtccaagta ccaacgaaca tgtacaacaa agaccctgca    600

attgtcaatg gggtttattg gtctgaatct ctaaacaaag tttttgtaga taactttgac    660

cgtgacccat ctctcatatg gcagtacttt ggaagtgcaa agggcttttt taggcagtat    720

ccggggatta aatgggaacc agatgagaat ggagtcattg ccttcgactg caggaaccga    780

aaatggtaca tccaggcagc aacttctccg aaagacgtgg tcattttagt tgacgtcagt    840

ggcagcatga aaggactccg tctgactatc gcgaagcaaa cagtctcatc cattttggat    900

acacttgggg atgatgactt cttcaacata attgcttata atgaggagct tcactatgtg    960

gaaccttgcc tgaatggaac tttggtgcaa gccgacagga caaacaaaga gcacttcagg   1020

gagcatctgg acaaactttt cgccaaagga attggaatgt tggatatagc tctgaatgag   1080

gccttcaaca ttctgagtga tttcaaccac acgggacaag gaagtatctg cagtcaggcc   1140

atcatgctca taactgatgg ggcggtggac acctatgata caatctttgc aaaatacaat   1200

tggccagatc gaaaggttcg catcttcaca tacctcattg gacgagaggc tgcgtttgca   1260

gacaatctaa agtggatggc ctgtgccaac aaaggatttt ttacccagat ctccaccttg   1320

gctgatgtgc aggagaatgt catggaatac cttcacgtgc ttagccggcc caaagtcatc   1380

gaccaggagc atgatgtggt gtggaccgaa gcttacattg acagcactct ccctcaggca   1440

caaaagctga ctgatgatca gggccccgtc ctgatgacca ctgtagccat gcctgtgttt   1500

agtaagcaga acgaaaccag atcgaagggc attcttctgg gagtggttgg cacagatgtc   1560

ccagtgaaag aacttctgaa gaccatcccc aaatacaagt tagggattca cggttatgcc   1620

tttgcaatca caaataatgg atatatcctg acgcatccgg aactcaggct gctgtacgaa   1680

gaaggaaaaa agcgaaggaa acctaactat agtagcgttg acctctctga ggtggagtgg   1740

gaagaccgag atgacgtgtt gagaaatgct atggtgaatc gaaagacggg gaagttttcc   1800

atggaggtga agaagacagt ggacaaaggg aaacgggttt tggtgatgac aaatgactac   1860

tattatacag acatcaaggg tactcctttc agtttaggtg tggcgctttc cagaggtcat   1920

gggaaatatt tcttccgagg gaatgtaacc atcgaagaag gcctgcatga cttagaacat   1980

cccgatgtgt ccttggcaga tgaatggtcc tactgcaaca ctgacctaca ccctgagcac   2040

cgccatctgt ctcagttaga agcgattaag ctctacctaa aaggcaaaga acctctgctc   2100

cagtgtgata aagaattgat ccaagaagtc ctttttgacg cggtggtgag tgcccccatt   2160

gaagcgtatt ggaccagcct ggccctcaac aaatctgaaa attctgacaa gggcgtggag   2220

gttgccttcc tcggcactcg cacgggcctc tccagaatca acctgtttgt cggggctgag   2280

cagctcacca atcaggactt cctgaaagct ggcgacaagg agaacatttt taacgcagac   2340

catttccctc tctggtaccg aagagccgct gagcagattc cagggagctt cgtctactcg   2400

atcccattca gcactggacc agtcaataaa agcaatgtgg tgacagcaag tacatccatc   2460

cagctcctgg atgaacggaa atctcctgtg gtggcagctg taggcattca gatgaaactt   2520

gaatttttcc aaaggaagtt ctggactgcc agcagacagt gtgcttccct ggatggcaaa   2580

tgctccatca gctgtgatga tgagactgtg aattgttacc tcatagacaa taatggattt   2640

attttggtgt ctgaagacta cacacagact ggagactttt ttggtgagat cgagggagct   2700

gtgatgaaca aattgctaac aatgggctcc tttaaaagaa ttacccttta tgactaccaa   2760

gccatgtgta gagccaacaa ggaaagcagc gatggcgccc atggcctcct ggatccttat   2820

aatgccttcc tctctgcagt aaaatggatc atgacagaac ttgtcttgtt cctggtggaa   2880

tttaacctct gcagttggtg gcactccgat atgacagcta aagcccagaa attgaaacag   2940

accctggagc cttgtgatac tgaatatcca gcattcgtct ctgagcgcac catcaaggag   3000

actacaggga atattgcttg tgaagactgc tccaagtcct ttgtcatcca gcaaatccca   3060

agcagcaacc tgttcatggt ggtggtggac agcagctgcc tctgtgaatc tgtggccccc   3120

atcaccatgg cacccattga aatcaggtat aatgaatccc ttaagtgtga acgtctaaag   3180

gcccagaaga tcagaaggcg cccagaatct tgtcatggct tccatcctga ggagaatgca   3240

agggagtgtg ggggtgcgcc gagtctccaa gcccagacag tcctccttct gctccctctg   3300

cttttgatgc tcttctcaag gtgacactga ctgagatgtt ctcttactga ctgagatgtt   3360

ctcttggcat gctaaatcat ggataaactg tgaaccaaaa tatggtgcaa catacgagac   3420

atgaatatag tccaaccatc agcatctcat catgatttta aactgtgcgt gatataaact   3480

cttaaagata tgttgacaaa aagttatcta tcatcttttt actttgccag tcatgcaaat   3540

gtgagtttgc cacatgataa tcacccttca tcagaaatgg gaccgcaagt ggtaggcagt   3600

gtcccttctg cttgaaacct attgaaacca atttaaaact gtgtactttt taaataaagt   3660

atattaaaat cataaaaaaa aaaaaaaaa                                     3689


<210>  794
<211>  1091
<212>  PRT
<213>  Homosapiens

<400>  794

Met Ala Gly Pro Gly Ser Pro Arg Arg Ala Ser Arg Gly Ala Ser Ala 
1               5                   10                  15      


Leu Leu Ala Ala Ala Leu Leu Tyr Ala Ala Leu Gly Asp Val Val Arg 
            20                  25                  30          


Ser Glu Gln Gln Ile Pro Leu Ser Val Val Lys Leu Trp Ala Ser Ala 
        35                  40                  45              


Phe Gly Gly Glu Ile Lys Ser Ile Ala Ala Lys Tyr Ser Gly Ser Gln 
    50                  55                  60                  


Leu Leu Gln Lys Lys Tyr Lys Glu Tyr Glu Lys Asp Val Ala Ile Glu 
65                  70                  75                  80  


Glu Ile Asp Gly Leu Gln Leu Val Lys Lys Leu Ala Lys Asn Met Glu 
                85                  90                  95      


Glu Met Phe His Lys Lys Ser Glu Ala Val Arg Arg Leu Val Glu Ala 
            100                 105                 110         


Ala Glu Glu Ala His Leu Lys His Glu Phe Asp Ala Asp Leu Gln Tyr 
        115                 120                 125             


Glu Tyr Phe Asn Ala Val Leu Ile Asn Glu Arg Asp Lys Asp Gly Asn 
    130                 135                 140                 


Phe Leu Glu Leu Gly Lys Glu Phe Ile Leu Ala Pro Asn Asp His Phe 
145                 150                 155                 160 


Asn Asn Leu Pro Val Asn Ile Ser Leu Ser Asp Val Gln Val Pro Thr 
                165                 170                 175     


Asn Met Tyr Asn Lys Asp Pro Ala Ile Val Asn Gly Val Tyr Trp Ser 
            180                 185                 190         


Glu Ser Leu Asn Lys Val Phe Val Asp Asn Phe Asp Arg Asp Pro Ser 
        195                 200                 205             


Leu Ile Trp Gln Tyr Phe Gly Ser Ala Lys Gly Phe Phe Arg Gln Tyr 
    210                 215                 220                 


Pro Gly Ile Lys Trp Glu Pro Asp Glu Asn Gly Val Ile Ala Phe Asp 
225                 230                 235                 240 


Cys Arg Asn Arg Lys Trp Tyr Ile Gln Ala Ala Thr Ser Pro Lys Asp 
                245                 250                 255     


Val Val Ile Leu Val Asp Val Ser Gly Ser Met Lys Gly Leu Arg Leu 
            260                 265                 270         


Thr Ile Ala Lys Gln Thr Val Ser Ser Ile Leu Asp Thr Leu Gly Asp 
        275                 280                 285             


Asp Asp Phe Phe Asn Ile Ile Ala Tyr Asn Glu Glu Leu His Tyr Val 
    290                 295                 300                 


Glu Pro Cys Leu Asn Gly Thr Leu Val Gln Ala Asp Arg Thr Asn Lys 
305                 310                 315                 320 


Glu His Phe Arg Glu His Leu Asp Lys Leu Phe Ala Lys Gly Ile Gly 
                325                 330                 335     


Met Leu Asp Ile Ala Leu Asn Glu Ala Phe Asn Ile Leu Ser Asp Phe 
            340                 345                 350         


Asn His Thr Gly Gln Gly Ser Ile Cys Ser Gln Ala Ile Met Leu Ile 
        355                 360                 365             


Thr Asp Gly Ala Val Asp Thr Tyr Asp Thr Ile Phe Ala Lys Tyr Asn 
    370                 375                 380                 


Trp Pro Asp Arg Lys Val Arg Ile Phe Thr Tyr Leu Ile Gly Arg Glu 
385                 390                 395                 400 


Ala Ala Phe Ala Asp Asn Leu Lys Trp Met Ala Cys Ala Asn Lys Gly 
                405                 410                 415     


Phe Phe Thr Gln Ile Ser Thr Leu Ala Asp Val Gln Glu Asn Val Met 
            420                 425                 430         


Glu Tyr Leu His Val Leu Ser Arg Pro Lys Val Ile Asp Gln Glu His 
        435                 440                 445             


Asp Val Val Trp Thr Glu Ala Tyr Ile Asp Ser Thr Leu Pro Gln Ala 
    450                 455                 460                 


Gln Lys Leu Thr Asp Asp Gln Gly Pro Val Leu Met Thr Thr Val Ala 
465                 470                 475                 480 


Met Pro Val Phe Ser Lys Gln Asn Glu Thr Arg Ser Lys Gly Ile Leu 
                485                 490                 495     


Leu Gly Val Val Gly Thr Asp Val Pro Val Lys Glu Leu Leu Lys Thr 
            500                 505                 510         


Ile Pro Lys Tyr Lys Leu Gly Ile His Gly Tyr Ala Phe Ala Ile Thr 
        515                 520                 525             


Asn Asn Gly Tyr Ile Leu Thr His Pro Glu Leu Arg Leu Leu Tyr Glu 
    530                 535                 540                 


Glu Gly Lys Lys Arg Arg Lys Pro Asn Tyr Ser Ser Val Asp Leu Ser 
545                 550                 555                 560 


Glu Val Glu Trp Glu Asp Arg Asp Asp Val Leu Arg Asn Ala Met Val 
                565                 570                 575     


Asn Arg Lys Thr Gly Lys Phe Ser Met Glu Val Lys Lys Thr Val Asp 
            580                 585                 590         


Lys Gly Lys Arg Val Leu Val Met Thr Asn Asp Tyr Tyr Tyr Thr Asp 
        595                 600                 605             


Ile Lys Gly Thr Pro Phe Ser Leu Gly Val Ala Leu Ser Arg Gly His 
    610                 615                 620                 


Gly Lys Tyr Phe Phe Arg Gly Asn Val Thr Ile Glu Glu Gly Leu His 
625                 630                 635                 640 


Asp Leu Glu His Pro Asp Val Ser Leu Ala Asp Glu Trp Ser Tyr Cys 
                645                 650                 655     


Asn Thr Asp Leu His Pro Glu His Arg His Leu Ser Gln Leu Glu Ala 
            660                 665                 670         


Ile Lys Leu Tyr Leu Lys Gly Lys Glu Pro Leu Leu Gln Cys Asp Lys 
        675                 680                 685             


Glu Leu Ile Gln Glu Val Leu Phe Asp Ala Val Val Ser Ala Pro Ile 
    690                 695                 700                 


Glu Ala Tyr Trp Thr Ser Leu Ala Leu Asn Lys Ser Glu Asn Ser Asp 
705                 710                 715                 720 


Lys Gly Val Glu Val Ala Phe Leu Gly Thr Arg Thr Gly Leu Ser Arg 
                725                 730                 735     


Ile Asn Leu Phe Val Gly Ala Glu Gln Leu Thr Asn Gln Asp Phe Leu 
            740                 745                 750         


Lys Ala Gly Asp Lys Glu Asn Ile Phe Asn Ala Asp His Phe Pro Leu 
        755                 760                 765             


Trp Tyr Arg Arg Ala Ala Glu Gln Ile Pro Gly Ser Phe Val Tyr Ser 
    770                 775                 780                 


Ile Pro Phe Ser Thr Gly Pro Val Asn Lys Ser Asn Val Val Thr Ala 
785                 790                 795                 800 


Ser Thr Ser Ile Gln Leu Leu Asp Glu Arg Lys Ser Pro Val Val Ala 
                805                 810                 815     


Ala Val Gly Ile Gln Met Lys Leu Glu Phe Phe Gln Arg Lys Phe Trp 
            820                 825                 830         


Thr Ala Ser Arg Gln Cys Ala Ser Leu Asp Gly Lys Cys Ser Ile Ser 
        835                 840                 845             


Cys Asp Asp Glu Thr Val Asn Cys Tyr Leu Ile Asp Asn Asn Gly Phe 
    850                 855                 860                 


Ile Leu Val Ser Glu Asp Tyr Thr Gln Thr Gly Asp Phe Phe Gly Glu 
865                 870                 875                 880 


Ile Glu Gly Ala Val Met Asn Lys Leu Leu Thr Met Gly Ser Phe Lys 
                885                 890                 895     


Arg Ile Thr Leu Tyr Asp Tyr Gln Ala Met Cys Arg Ala Asn Lys Glu 
            900                 905                 910         


Ser Ser Asp Gly Ala His Gly Leu Leu Asp Pro Tyr Asn Ala Phe Leu 
        915                 920                 925             


Ser Ala Val Lys Trp Ile Met Thr Glu Leu Val Leu Phe Leu Val Glu 
    930                 935                 940                 


Phe Asn Leu Cys Ser Trp Trp His Ser Asp Met Thr Ala Lys Ala Gln 
945                 950                 955                 960 


Lys Leu Lys Gln Thr Leu Glu Pro Cys Asp Thr Glu Tyr Pro Ala Phe 
                965                 970                 975     


Val Ser Glu Arg Thr Ile Lys Glu Thr Thr Gly Asn Ile Ala Cys Glu 
            980                 985                 990         


Asp Cys Ser Lys Ser Phe Val Ile  Gln Gln Ile Pro Ser  Ser Asn Leu 
        995                 1000                 1005             


Phe Met  Val Val Val Asp Ser  Ser Cys Leu Cys Glu  Ser Val Ala 
    1010                 1015                 1020             


Pro Ile  Thr Met Ala Pro Ile  Glu Ile Arg Tyr Asn  Glu Ser Leu 
    1025                 1030                 1035             


Lys Cys  Glu Arg Leu Lys Ala  Gln Lys Ile Arg Arg  Arg Pro Glu 
    1040                 1045                 1050             


Ser Cys  His Gly Phe His Pro  Glu Glu Asn Ala Arg  Glu Cys Gly 
    1055                 1060                 1065             


Gly Ala  Pro Ser Leu Gln Ala  Gln Thr Val Leu Leu  Leu Leu Pro 
    1070                 1075                 1080             


Leu Leu  Leu Met Leu Phe Ser  Arg 
    1085                 1090     


<210>  795
<211>  3561
<212>  DNA
<213>  Homosapiens

<400>  795
ccggctgtcg gtctccgtgt cgccgccgcc gcccggcatc gtggagctgg ggcccccttt     60

tgcctgggag ttttgtagtc gcctagggtc agcggtgaca tcccaaaggg caggcccggc    120

agccgccatg gtggccaagg attacccctt ctacctcacg gtcaagagag cgaactgcag    180

cctggagcta cctccggcca gcggtccggc caaggacgct gaggagccta gtaataaacg    240

ggtcaaaccc ctttcccgag tcacgtcgct agcaaacctc atcccgcccg tgaaggccac    300

gccattaaag cgcttcagtc aaaccctgca gcgctccatt agcttccgca gtgagagccg    360

ccctgacatc ctcgcccccc gaccctggtc cagaaatgcc gccccctcga gcacgaaacg    420

gagagatagc aagctgtgga gtgagacctt cgatgtgtgc gtcaatcaga tgcttacatc    480

caaggaaatc aaacgtcagg aggcgatctt tgagctttcc caaggagaag aagacttgat    540

agaagacttg aaattagcaa aaaaggccta tcatgacccc atgctgaaac tctccataat    600

gacagaacaa gagttgaatc aaatttttgg aacactggac tctctaattc ctctacatga    660

agagctcctt agtcagcttc gagatgttag gaagcctgat ggctcgactg aacatgttgg    720

tcccatcctc gtgggctggc tcccttgcct cagctcctat gatagctact gcagcaatca    780

agtagccgcc aaagctctgc tggaccacaa aaagcaagat caccgagtcc aggatttcct    840

acagcgatgt ttagaatccc cctttagccg caaactagat ctctggaatt tcctcgatat    900

tccaagaagc cgcctggtaa aataccctct gcttctccga gaaatcttga ggcacacacc    960

aaatgataat ccagatcagc agcacttgga agaagctata aatatcattc agggaattgt   1020

ggcagaaatc aacaccaaga ctggtgaatc tgaatgccgc tattataaag agcggcttct   1080

ttacttggaa gaaggccaga aagactccct gatcgacagc tctcgagtct tgtgttgtca   1140

tggtgaactg aagaacaatc ggggcgtgaa actgcatgtt ttcctgttcc aagaagtgct   1200

tgtgatcact cgagccgtca cccacaatga gcagctttgc taccagctgt accgtcagcc   1260

aatccccgtg aaagacctcc tgctggaaga cctccaggat ggagaagtga ggctgggtgg   1320

ctccctgcga ggggcattca gcaacaatga gagaattaaa aacttcttca gagtcagttt   1380

caaaaatgga tcccaaagtc agacccactc gctacaagcc aatgacactt tcaacaaaca   1440

gcagtggctt aactgtattc gtcaagccaa agaaacagtt ttgtgtgctg ccgggcaagc   1500

tggggtgctt gactccgagg gatcgttcct aaatcccacc accgggagca gagagctaca   1560

gggagaaaca aaacttgagc agatggacca atcggacagt gagtcagact gtagtatgga   1620

cacgagtgag gtcagcctcg actgtgagcg catggaacag acagactctt cctgtggaaa   1680

cagcaggcac ggtgaaagta acgtctgaca gaagcatgtg cacttcggga agcaggcctg   1740

catcttacct gtacagtatt tgcattccac agatggaacg gtttggagaa gcactttttc   1800

atacttttgt gaaagtatac atgttggccc agtctctcgt atctgtacct ttgtccctag   1860

tactgtaact gccaatctgt ctgtgtaagc tggaatctgt ggcaactatt accctgtgtt   1920

gtatttccca agtgtctgga tggatggaga ggtactcaaa caagttactt tcagttgtcc   1980

tgctggattt taaaaaaata gaaaaagaat ctcaaaacta ctgttttaca tagattgttt   2040

gaagagtcct tcctcttgtg cttctgtacc actttcccag ctcttagatg tggtagctaa   2100

aggcacggaa tttagacggc cttgtaaata gggcatgagg aactcatctg tgtattggga   2160

tggtattaga gagagaatca ggaaagacca actcatgaag tgaacttggt ttgatcttac   2220

tcaactagaa agcttgaaaa catccctggg gattctgaag gcttaatttt gcaaaggagg   2280

atgcattgtc tgaactttgc aacttcatcc agtgcaagtt tgatgcaaga atgtattagg   2340

acataaaata gaggctgacc ttaaaagggc caggacagaa gcggctgcca gctctgaatc   2400

tttaactgaa atgcacatgg caccaggagg tgtctctcat agttggttgc tagcctaaaa   2460

catcagaata gaacccaaag ggcttaggaa ggcctgccag gataacaaga aggccctgta   2520

ttcattgtgt ttcatctgcc taggcctact cattatttta gagaatgaat gaagcaacaa   2580

ggaagagaga acatgactct atcgatgaca ctgtttatag aaacacagga gaggaagaat   2640

ttggaatgaa aagcacttcg tcagaacctt ctgtgggagc cattgagaga aaagcatggt   2700

ccagtgcctt ctgagaaagg ccagagcttt gggctttcct gctctgcttt tgggtcgtca   2760

atttgccatc tctggttctg tgctataatc agaattgtaa ttatgttctc cagaggccaa   2820

tttcattaac tctgattaat tagaatcagc tagccagatt agtaacctct ttgtccagcc   2880

ttgatttaca gtgcagggta aagtgcagac cttaaaaaca gctaagtacc tagaagagct   2940

ccctgcaagt gtaaatatta aggatgacct gtgcaaaatt atacccacac cagcactagt   3000

ggtaattatt ctaaattatt gccaaaaagt tttttttaat ctgtctttca agtttacaga   3060

aaagaaagca gtaaatgcat tgatgtcatt ttattatgta catatatcat gtgcattcaa   3120

gctgtgtgac aagatatatc aatataaaaa caaggtatat actttattat tttttgaaaa   3180

caaggatatt gtgatcaatt ttaccctgta aaacatattt ctgtatttat aggtcttaaa   3240

catgatgaat tttttctatt acaagtttat ttaaaactgc tttctcaagt cgttattgat   3300

acagcaagtg aacctgctgc agacagaagc agaggaaagc caagaacagc ctttattggt   3360

gaagaaaaga atgaatgatt ctttgtaggc gccatcagcc acttttagaa gccatcagcc   3420

agtgtgttgg gaaaagaggt ttgtcaagtg ttggcctatg ggaaggtggt caatgaatgt   3480

tttgatgaaa tgaatgtttt tgtataatgg ccttaaactt ttctggaagt atttcaaata   3540

aattacatta ttaagtcatc a                                             3561


<210>  796
<211>  526
<212>  PRT
<213>  Homosapiens

<400>  796

Met Val Ala Lys Asp Tyr Pro Phe Tyr Leu Thr Val Lys Arg Ala Asn 
1               5                   10                  15      


Cys Ser Leu Glu Leu Pro Pro Ala Ser Gly Pro Ala Lys Asp Ala Glu 
            20                  25                  30          


Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Thr Ser Leu 
        35                  40                  45              


Ala Asn Leu Ile Pro Pro Val Lys Ala Thr Pro Leu Lys Arg Phe Ser 
    50                  55                  60                  


Gln Thr Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser Arg Pro Asp 
65                  70                  75                  80  


Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro Ser Ser Thr 
                85                  90                  95      


Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Thr Phe Asp Val Cys Val 
            100                 105                 110         


Asn Gln Met Leu Thr Ser Lys Glu Ile Lys Arg Gln Glu Ala Ile Phe 
        115                 120                 125             


Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu Lys Leu Ala 
    130                 135                 140                 


Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Thr Glu 
145                 150                 155                 160 


Gln Glu Leu Asn Gln Ile Phe Gly Thr Leu Asp Ser Leu Ile Pro Leu 
                165                 170                 175     


His Glu Glu Leu Leu Ser Gln Leu Arg Asp Val Arg Lys Pro Asp Gly 
            180                 185                 190         


Ser Thr Glu His Val Gly Pro Ile Leu Val Gly Trp Leu Pro Cys Leu 
        195                 200                 205             


Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln Val Ala Ala Lys Ala Leu 
    210                 215                 220                 


Leu Asp His Lys Lys Gln Asp His Arg Val Gln Asp Phe Leu Gln Arg 
225                 230                 235                 240 


Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp Asn Phe Leu 
                245                 250                 255     


Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu Leu Arg Glu 
            260                 265                 270         


Ile Leu Arg His Thr Pro Asn Asp Asn Pro Asp Gln Gln His Leu Glu 
        275                 280                 285             


Glu Ala Ile Asn Ile Ile Gln Gly Ile Val Ala Glu Ile Asn Thr Lys 
    290                 295                 300                 


Thr Gly Glu Ser Glu Cys Arg Tyr Tyr Lys Glu Arg Leu Leu Tyr Leu 
305                 310                 315                 320 


Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp Ser Ser Arg Val Leu Cys 
                325                 330                 335     


Cys His Gly Glu Leu Lys Asn Asn Arg Gly Val Lys Leu His Val Phe 
            340                 345                 350         


Leu Phe Gln Glu Val Leu Val Ile Thr Arg Ala Val Thr His Asn Glu 
        355                 360                 365             


Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro Ile Pro Val Lys Asp Leu 
    370                 375                 380                 


Leu Leu Glu Asp Leu Gln Asp Gly Glu Val Arg Leu Gly Gly Ser Leu 
385                 390                 395                 400 


Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile Lys Asn Phe Phe Arg Val 
                405                 410                 415     


Ser Phe Lys Asn Gly Ser Gln Ser Gln Thr His Ser Leu Gln Ala Asn 
            420                 425                 430         


Asp Thr Phe Asn Lys Gln Gln Trp Leu Asn Cys Ile Arg Gln Ala Lys 
        435                 440                 445             


Glu Thr Val Leu Cys Ala Ala Gly Gln Ala Gly Val Leu Asp Ser Glu 
    450                 455                 460                 


Gly Ser Phe Leu Asn Pro Thr Thr Gly Ser Arg Glu Leu Gln Gly Glu 
465                 470                 475                 480 


Thr Lys Leu Glu Gln Met Asp Gln Ser Asp Ser Glu Ser Asp Cys Ser 
                485                 490                 495     


Met Asp Thr Ser Glu Val Ser Leu Asp Cys Glu Arg Met Glu Gln Thr 
            500                 505                 510         


Asp Ser Ser Cys Gly Asn Ser Arg His Gly Glu Ser Asn Val 
        515                 520                 525     


<210>  797
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  797
gcggccaggg gcgggcggcc gcagagcagc accggccgtg gctccggtag cagcaagttc     60

gaaccccgct cccgctccgc ttcggttctc gctccttcgg cccttgggcc tccaaacacc    120

agtccccggc agctcgttgc gcattgcgct ctccccgcca ccaggatgcc ggtaaccgag    180

aaggatctag ctgaggacgc gccttggaag aagatccagc agaacacgtt cacacgctgg    240

tgcaacgagc acctcaagtg cgtgaacaaa cgcatcggca acctgcagac cgacctgagc    300

gacgggctgc ggctcatcgc gctgctcgag gtgctcagcc agaagcgcat gtaccgcaag    360

taccatcagc ggcccacctt tcgccagatg cagctcgaga atgtgtccgt ggcgctcgag    420

ttcctggacc gtgagagcat caagctcgtg tccatcgata gcaaagccat tgtggatggg    480

aacctgaagc tcatcttggg tctggtgtgg acgctgatcc tccactactc catctccatg    540

cccgtgtggg aggatgaagg ggatgatgat gccaagaagc agacgccaaa gcagaggctg    600

ctggggtgga ttcagaacaa gatcccctac ttgcccatca ccaactttaa ccagaactgg    660

caagacggca aagccctggg agccctggta gacagctgtg ctccaggtct gtgcccagac    720

tgggaatcct gggacccgca gaagcctgtg gataatgcac gagaagccat gcagcaggca    780

gatgactggc tgggtgtccc acaggtcatc actcctgaag aaatcattca cccggatgtg    840

gacgagcact cagttatgac ttacctgtcc cagttcccca aagccaagct caagccgggg    900

gctcctctca aacccaaact caacccgaag aaagccaggg cctatggcag aggaatcgag    960

cccactggaa acatggtgaa gcagccagcc aagttcactg tggacaccat cagcgccggg   1020

caaggagacg tgatggtgtt tgttgaggac ccagaaggga acaaagagga ggcacaagtg   1080

acccctgaca gtgacaagaa caagacatac tctgtggagt atctgcccaa ggtcaccggg   1140

ctacacaaag tcacagtcct ctttgcagga cagcacatct ccaagagccc atttgaagtg   1200

agtgttgaca aggcccaggg agatgccagt aaagtcactg caaaaggtcc agggttggaa   1260

gctgtaggga acatcgccaa taagcccacc tactttgaca tctatacggc aggagctggt   1320

gtgggtgaca ttggtgtgga ggtggaagat ccccagggga agaacaccgt ggagttgctc   1380

gtggaagaca aaggaaacca ggtgtatcga tgtgtgtaca aacccatgca gcctggccct   1440

cacgtggtca agatcttctt tgctggggac actattccta agagtccctt cgttgtgcag   1500

gttggggaag cctgcaatcc aaatgcctgc cgggccagtg gccgaggcct acaacccaaa   1560

ggcgtccgta tccgggagac cacagatttc aaggttgaca ccaaagctgc aggaagtggg   1620

gagctcggtg taaccatgaa gggtcctaag ggtctggagg agctggtgaa gcagaaagac   1680

tttctggatg gggtctacgc attcgagtat taccccagca ccccggggag atacagcatt   1740

gccatcacat gggggggaca ccacattcca aagagcccct ttgaagttca agttggccct   1800

gaagcgggta tgcagaaagt ccgtgcttgg ggccctgggc tccatggtgg gattgtcggg   1860

cggtcagcgg acttcgtggt agaatccatt ggctctgaag tggggtctct ggggtttgcc   1920

attgaaggcc cctctcaggc aaagattgag tacaacgacc agaatgatgg atcgtgtgat   1980

gtcaaatact ggcccaagga gcctggcgaa tatgctgttc acatcatgtg tgacgacgaa   2040

gacatcaagg acagcccgta catggccttc atccacccag ccacgggagg ctacaaccct   2100

gatctggttc gagcatacgg gccaggtttg gagaaatctg gatgcattgt caacaacctg   2160

gccgagttca ctgtggatcc taaggatgct ggaaaagctc ccttaaagat atttgctcag   2220

gatggggaag gccaacgcat tgacatccag atgaagaacc ggatggacgg cacatatgca   2280

tgctcataca ccccggtgaa ggccatcaag cacaccattg ctgtggtctg gggaggcgtg   2340

aacatcccgc acagccccta cagggtcaac atcgggcaag gtagccatcc tcagaaggtc   2400

aaagtgtttg ggccaggtgt ggagagaagt ggtctgaagg caaatgaacc tacacacttc   2460

acggtggact gtactgaggc tggggaaggt gatgtcagtg ttggcattaa gtgtgatgcc   2520

cgggtgttaa gtgaagatga ggaagacgtg gattttgaca ttattcacaa tgccaatgat   2580

acgttcacag tcaaatatgt gcctcctgct gctgggcgat acactatcaa agttctcttt   2640

gcatctcagg aaatccccgc cagccctttc agagtcaaag ttgacccttc ccacgatgcc   2700

agcaaagtga aggcagaagg cccagggctc agcaaagcag gtgtggaaaa tgggaaaccg   2760

acccacttca ctgtctacac caagggggct gggaaagccc cgctcaacgt gcagttcaac   2820

agccctcttc ctggcgatgc agtgaaggat ttggatatca tcgataatta tgactactct   2880

cacacggtta aatatacacc cacccaacag ggcaacatgc aggttctggt gacttacggt   2940

ggcgatccca tccctaaaag ccctttcact gtgggtgttg ctgcaccgct ggatctgagc   3000

aagataaaac tcaatgggct ggaaaacagg gtggaagttg ggaaggatca ggagttcacc   3060

gttgatacca ggggggcagg aggccagggg aagctggacg tgacaatcct cagcccctct   3120

cggaaggtcg tgccatgcct agtgacacct gtgacaggcc gggagaacag cacggccaag   3180

ttcatccctc gggaggaggg gctgtatgct gtagacgtga cctacgatgg acaccctgtg   3240

cccgggagcc cctacacagt ggaggcctcg ctgccaccag atcccagcaa ggtgaaggcc   3300

cacggtcccg gcctcgaagg tggtctcgtg ggcaagcctg ccgagttcac catcgatacc   3360

aaaggagctg gtactggagg tctgggctta acggtggaag gtccgtgcga ggccaaaatc   3420

gagtgctccg acaatggtga tgggacctgc tccgtctctt accttcccac aaaacccggg   3480

gagtacttcg tcaacatcct ctttgaagaa gtccacatac ctgggtctcc cttcaaagct   3540

gacattgaaa tgccctttga cccctctaaa gtcgtggcat cggggccagg tctcgagcac   3600

gggaaggtgg gtgaagctgg cctccttagc gtcgactgct cggaagcggg accgggggcc   3660

ctgggcctgg aagctgtctc ggactcggga acaaaagccg aagtcagtat tcagaacaac   3720

aaagatggca cctacgcggt gacctacgtg cccctgacgg ccggcatgta cacgttgacc   3780

atgaagtatg gtggcgaact cgtgccacac ttccccgccc gggtcaaggt ggagcccgcc   3840

gtggacacca gcaggatcaa agtctttgga ccaggaatag aagggaaaga tgtgttccgg   3900

gaagctacca ccgactttac agttgactct cggccgctga cccaggttgg gggtgaccac   3960

atcaaggccc acattgccaa cccctcaggg gcctccaccg agtgctttgt cacagacaat   4020

gcggatggga cctaccaggt ggaatacaca ccctttgaga aaggtctcca tgtagtggag   4080

gtgacatatg atgacgtgcc tatcccaaac agtcccttca aggtggctgt cactgaaggc   4140

tgccagccat ctagggtgca agcccaagga cctggattga aagaggcctt taccaacaag   4200

cccaatgtct tcaccgtggt taccagaggc gcaggaattg gtgggcttgg cataactgtt   4260

gagggaccat cagagtcgaa gataaattgc agagacaaca aggatggcag ctgcagtgct   4320

gagtacattc ctttcgcacc gggggattac gatgttaata tcacatatgg aggagcccac   4380

atccccggca gccccttcag ggttcctgtg aaggatgttg tggaccccag caaggtcaag   4440

attgccggcc ccgggctggg ctcaggcgtc cgagcccgtg tcctgcagtc cttcacggtg   4500

gacagcagca aggctggcct ggctccgctg gaagtgaggg ttctgggccc acgaggcttg   4560

gtggagccag tgaacgtggt ggacaatgga gatggcacac acacagtaac ctacacccca   4620

tctcaggagg gaccttacat ggtctcagtt aaatatgctg atgaagagat tcctcgcagt   4680

cccttcaagg tcaaggtcct tcccacatat gatgccagca aagtgactgc cagtggcccc   4740

ggccttagtt cctatggtgt gcctgccagt ctacctgtgg actttgcaat tgatgcccga   4800

gatgccgggg aaggcctgct tgctgttcaa ataacggacc aagaaggaaa acccaaaaga   4860

gccattgtcc atgacaataa agatggcacg tatgctgtca cctacatccc cgacaagact   4920

gggcgctata tgattggagt cacctacggg ggtgacgaca tcccactttc tccttatcgc   4980

atccgagcca cacagacggg tgatgccagc aagtgcctgg ccacgggtcc tggaatcgcc   5040

tccactgtga aaactggcga agaagtaggc tttgtggttg atgccaagac tgccgggaag   5100

ggtaaagtga cctgcacggt tctgacccca gatggcactg aggccgaggc cgatgtcatt   5160

gagaatgaag atggaaccta tgacatcttc tacacagctg ccaagccggg cacatatgtg   5220

atctatgtgc gcttcggtgg tgttgatatt cctaacagcc ccttcactgt catggccaca   5280

gatggggaag tcacagccgt ggaggaggca ccggtaaatg catgtccccc tggattcagg   5340

ccctgggtga ccgaagaggc ctatgtccca gtgagtgaca tgaacggcct gggatttaag   5400

ccttttgacc tggtcattcc gtttgctgtc aggaaaggag aaatcactgg agaggtccac   5460

atgccttctg ggaagacagc cacacctgag attgtggaca acaaggacgg cacggtcact   5520

gttagatatg cccccactga ggtcgggctc catgagatgc acatcaaata catgggcagc   5580

cacatccctg agagcccact ccagttctac gtgaactacc ccaacagtgg aagtgtttct   5640

gcatacggtc caggcctcgt gtatggagtg gccaacaaaa ctgccacctt caccatcgtc   5700

acagaggatg caggagaagg tggtctggac ttggctattg agggcccctc aaaagcagaa   5760

atcagctgca ttgacaataa agatgggaca tgcacagtga cctacctgcc gactctgcca   5820

ggcgactaca gcattctggt caagtacaat gacaagcaca tccctggcag ccccttcaca   5880

gccaagatca cagatgacag caggcggtgc tcccaggtga agttgggctc agccgctgac   5940

ttcctgctcg acatcagtga gactgacctc agcagcctga cggccagcat taaggcccca   6000

tctggccgag acgagccctg tctcctgaag aggctgccca acaaccacat tggcatctcc   6060

ttcatccccc gggaagtggg cgaacatctg gtcagcatca agaaaaatgg caaccatgtg   6120

gccaacagcc ccgtgtctat catggtggtc cagtcggaga ttggtgacgc ccgccgagcc   6180

aaagtctatg gccgcggcct gtcagaaggc cggactttcg agatgtctga cttcatcgtg   6240

gacacaaggg atgcaggtta tggtggcata tccttggcgg tggaaggccc cagcaaagtg   6300

gacatccaga cggaggacct ggaagatggc acctgcaaag tctcctactt ccctaccgtg   6360

cctggggttt atatcgtctc caccaaattc gctgacgagc acgtgcctgg gagcccattt   6420

accgtgaaga tcagtgggga gggaagagtc aaagagagca tcacccgcac cagtcgggcc   6480

ccgtccgtgg ccactgtcgg gagcatttgt gacctgaacc tgaaaatccc agaaatcaac   6540

agcagtgata tgtcggccca cgtcaccagc ccctctggcc gtgtgactga ggcagagatt   6600

gtgcccatgg ggaagaactc acactgcgtc cggtttgtgc cccaggagat gggcgtgcac   6660

acggtcagcg tcaagtaccg tgggcagcac gtcaccggca gccccttcca gttcaccgtg   6720

gggccacttg gtgaaggagg cgcccacaag gtgcgggcag gaggccctgg cctggagaga   6780

ggagaagcgg gagtcccagc tgagttcagc atttggaccc gggaagcagg cgctggaggc   6840

ctctccatcg ctgttgaggg ccccagtaag gccgagatta cattcgatga ccataaaaat   6900

gggtcgtgcg gtgtatctta tattgcccaa gagcctggta actacgaggt gtccatcaag   6960

ttcaatgatg agcacatccc ggaaagcccc tacctggtgc cggtcatcgc accctccgac   7020

gacgcccgcc gcctcactgt tatgagcctt caggaatcgg gattaaaagt taaccagcca   7080

gcatcctttg ctataaggtt gaatggcgca aaaggcaaga ttgatgcaaa ggtgcacagc   7140

ccctctggag ccgtggagga gtgccacgtg tctgagctgg agccagataa gtatgctgtt   7200

cgcttcatcc ctcatgagaa tggtgtccac accatcgatg tcaagttcaa tgggagccac   7260

gtggttggaa gccccttcaa agtgcgcgtt ggggagcctg gacaagcggg gaaccctgcc   7320

ctggtgtccg cctatggcac gggactcgaa gggggcacca caggtatcca gtcggaattc   7380

tttattaaca ccacccgagc aggtccaggg acattatccg tcaccatcga aggcccatcc   7440

aaggttaaaa tggattgcca ggaaacacct gaagggtaca aagtcatgta cacccccatg   7500

gctcctggta actacctgat cagcgtcaaa tacggtgggc ccaaccacat cgtgggcagt   7560

cccttcaagg ccaaggtgac aggccagcgt ctagttagcc ctggctcagc caacgagacc   7620

tcatccatcc tggtggagtc agtgaccagg tcgtctacag agacctgcta tagcgccatt   7680

cccaaggcat cctcggacgc cagcaaggtg acctctaagg gggcagggct ctcaaaggcc   7740

tttgtgggcc agaagagttc cttcctggtg gactgcagca aagctggctc caacatgctg   7800

ctgatcgggg tccatgggcc caccaccccc tgcgaggagg tctccatgaa gcatgtaggc   7860

aaccagcaat acaacgtcac atacgtcgtc aaggagaggg gcgattatgt gctggctgtg   7920

aagtgggggg aggaacacat ccctggcagc ccttttcatg tcacagtgcc ttaaaacagt   7980

tttctcaaat cctggagaga gttcttgtgg ttgcttttgt tgcttgtttg taattcattt   8040

tatacaaagc cctccagcct gtttgtgggg ctgaaacccc atccctaaaa tattgctgtt   8100

gtaaaatgcc ttcagaaata agtcctagac tggactcttg agggacatat tggagaatct   8160

taagaaatgc aagcttgttc agggggctga ga                                 8192


<210>  798
<211>  2602
<212>  PRT
<213>  Homosapiens

<400>  798

Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys 
1               5                   10                  15      


Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys 
            20                  25                  30          


Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu 
        35                  40                  45              


Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg 
    50                  55                  60                  


Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val 
65                  70                  75                  80  


Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser 
                85                  90                  95      


Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly 
            100                 105                 110         


Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp 
        115                 120                 125             


Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg 
    130                 135                 140                 


Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn 
145                 150                 155                 160 


Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp 
                165                 170                 175     


Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln 
            180                 185                 190         


Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp 
        195                 200                 205             


Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp 
    210                 215                 220                 


Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala 
225                 230                 235                 240 


Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys 
                245                 250                 255     


Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys 
            260                 265                 270         


Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp 
        275                 280                 285             


Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln 
    290                 295                 300                 


Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu 
305                 310                 315                 320 


Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln 
                325                 330                 335     


His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly 
            340                 345                 350         


Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly 
        355                 360                 365             


Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala 
    370                 375                 380                 


Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn 
385                 390                 395                 400 


Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys 
                405                 410                 415     


Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe 
            420                 425                 430         


Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu 
        435                 440                 445             


Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro 
    450                 455                 460                 


Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys 
465                 470                 475                 480 


Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly 
                485                 490                 495     


Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala 
            500                 505                 510         


Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr 
        515                 520                 525             


Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly 
    530                 535                 540                 


Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His 
545                 550                 555                 560 


Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly 
                565                 570                 575     


Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala 
            580                 585                 590         


Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr 
        595                 600                 605             


Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp 
    610                 615                 620                 


Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr 
625                 630                 635                 640 


Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu 
                645                 650                 655     


Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro 
            660                 665                 670         


Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu 
        675                 680                 685             


Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr 
    690                 695                 700                 


Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val 
705                 710                 715                 720 


Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile 
                725                 730                 735     


Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val 
            740                 745                 750         


Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp 
        755                 760                 765             


Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp 
    770                 775                 780                 


Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile 
785                 790                 795                 800 


His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala 
                805                 810                 815     


Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala 
            820                 825                 830         


Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val 
        835                 840                 845             


Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys 
    850                 855                 860                 


Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu 
865                 870                 875                 880 


Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu 
                885                 890                 895     


Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro 
            900                 905                 910         


Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro 
        915                 920                 925             


Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu 
    930                 935                 940                 


Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys 
945                 950                 955                 960 


Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys 
                965                 970                 975     


Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu 
            980                 985                 990         


Val Thr Pro Val Thr Gly Arg Glu  Asn Ser Thr Ala Lys  Phe Ile Pro 
        995                 1000                 1005             


Arg Glu  Glu Gly Leu Tyr Ala  Val Asp Val Thr Tyr  Asp Gly His 
    1010                 1015                 1020             


Pro Val  Pro Gly Ser Pro Tyr  Thr Val Glu Ala Ser  Leu Pro Pro 
    1025                 1030                 1035             


Asp Pro  Ser Lys Val Lys Ala  His Gly Pro Gly Leu  Glu Gly Gly 
    1040                 1045                 1050             


Leu Val  Gly Lys Pro Ala Glu  Phe Thr Ile Asp Thr  Lys Gly Ala 
    1055                 1060                 1065             


Gly Thr  Gly Gly Leu Gly Leu  Thr Val Glu Gly Pro  Cys Glu Ala 
    1070                 1075                 1080             


Lys Ile  Glu Cys Ser Asp Asn  Gly Asp Gly Thr Cys  Ser Val Ser 
    1085                 1090                 1095             


Tyr Leu  Pro Thr Lys Pro Gly  Glu Tyr Phe Val Asn  Ile Leu Phe 
    1100                 1105                 1110             


Glu Glu  Val His Ile Pro Gly  Ser Pro Phe Lys Ala  Asp Ile Glu 
    1115                 1120                 1125             


Met Pro  Phe Asp Pro Ser Lys  Val Val Ala Ser Gly  Pro Gly Leu 
    1130                 1135                 1140             


Glu His  Gly Lys Val Gly Glu  Ala Gly Leu Leu Ser  Val Asp Cys 
    1145                 1150                 1155             


Ser Glu  Ala Gly Pro Gly Ala  Leu Gly Leu Glu Ala  Val Ser Asp 
    1160                 1165                 1170             


Ser Gly  Thr Lys Ala Glu Val  Ser Ile Gln Asn Asn  Lys Asp Gly 
    1175                 1180                 1185             


Thr Tyr  Ala Val Thr Tyr Val  Pro Leu Thr Ala Gly  Met Tyr Thr 
    1190                 1195                 1200             


Leu Thr  Met Lys Tyr Gly Gly  Glu Leu Val Pro His  Phe Pro Ala 
    1205                 1210                 1215             


Arg Val  Lys Val Glu Pro Ala  Val Asp Thr Ser Arg  Ile Lys Val 
    1220                 1225                 1230             


Phe Gly  Pro Gly Ile Glu Gly  Lys Asp Val Phe Arg  Glu Ala Thr 
    1235                 1240                 1245             


Thr Asp  Phe Thr Val Asp Ser  Arg Pro Leu Thr Gln  Val Gly Gly 
    1250                 1255                 1260             


Asp His  Ile Lys Ala His Ile  Ala Asn Pro Ser Gly  Ala Ser Thr 
    1265                 1270                 1275             


Glu Cys  Phe Val Thr Asp Asn  Ala Asp Gly Thr Tyr  Gln Val Glu 
    1280                 1285                 1290             


Tyr Thr  Pro Phe Glu Lys Gly  Leu His Val Val Glu  Val Thr Tyr 
    1295                 1300                 1305             


Asp Asp  Val Pro Ile Pro Asn  Ser Pro Phe Lys Val  Ala Val Thr 
    1310                 1315                 1320             


Glu Gly  Cys Gln Pro Ser Arg  Val Gln Ala Gln Gly  Pro Gly Leu 
    1325                 1330                 1335             


Lys Glu  Ala Phe Thr Asn Lys  Pro Asn Val Phe Thr  Val Val Thr 
    1340                 1345                 1350             


Arg Gly  Ala Gly Ile Gly Gly  Leu Gly Ile Thr Val  Glu Gly Pro 
    1355                 1360                 1365             


Ser Glu  Ser Lys Ile Asn Cys  Arg Asp Asn Lys Asp  Gly Ser Cys 
    1370                 1375                 1380             


Ser Ala  Glu Tyr Ile Pro Phe  Ala Pro Gly Asp Tyr  Asp Val Asn 
    1385                 1390                 1395             


Ile Thr  Tyr Gly Gly Ala His  Ile Pro Gly Ser Pro  Phe Arg Val 
    1400                 1405                 1410             


Pro Val  Lys Asp Val Val Asp  Pro Ser Lys Val Lys  Ile Ala Gly 
    1415                 1420                 1425             


Pro Gly  Leu Gly Ser Gly Val  Arg Ala Arg Val Leu  Gln Ser Phe 
    1430                 1435                 1440             


Thr Val  Asp Ser Ser Lys Ala  Gly Leu Ala Pro Leu  Glu Val Arg 
    1445                 1450                 1455             


Val Leu  Gly Pro Arg Gly Leu  Val Glu Pro Val Asn  Val Val Asp 
    1460                 1465                 1470             


Asn Gly  Asp Gly Thr His Thr  Val Thr Tyr Thr Pro  Ser Gln Glu 
    1475                 1480                 1485             


Gly Pro  Tyr Met Val Ser Val  Lys Tyr Ala Asp Glu  Glu Ile Pro 
    1490                 1495                 1500             


Arg Ser  Pro Phe Lys Val Lys  Val Leu Pro Thr Tyr  Asp Ala Ser 
    1505                 1510                 1515             


Lys Val  Thr Ala Ser Gly Pro  Gly Leu Ser Ser Tyr  Gly Val Pro 
    1520                 1525                 1530             


Ala Ser  Leu Pro Val Asp Phe  Ala Ile Asp Ala Arg  Asp Ala Gly 
    1535                 1540                 1545             


Glu Gly  Leu Leu Ala Val Gln  Ile Thr Asp Gln Glu  Gly Lys Pro 
    1550                 1555                 1560             


Lys Arg  Ala Ile Val His Asp  Asn Lys Asp Gly Thr  Tyr Ala Val 
    1565                 1570                 1575             


Thr Tyr  Ile Pro Asp Lys Thr  Gly Arg Tyr Met Ile  Gly Val Thr 
    1580                 1585                 1590             


Tyr Gly  Gly Asp Asp Ile Pro  Leu Ser Pro Tyr Arg  Ile Arg Ala 
    1595                 1600                 1605             


Thr Gln  Thr Gly Asp Ala Ser  Lys Cys Leu Ala Thr  Gly Pro Gly 
    1610                 1615                 1620             


Ile Ala  Ser Thr Val Lys Thr  Gly Glu Glu Val Gly  Phe Val Val 
    1625                 1630                 1635             


Asp Ala  Lys Thr Ala Gly Lys  Gly Lys Val Thr Cys  Thr Val Leu 
    1640                 1645                 1650             


Thr Pro  Asp Gly Thr Glu Ala  Glu Ala Asp Val Ile  Glu Asn Glu 
    1655                 1660                 1665             


Asp Gly  Thr Tyr Asp Ile Phe  Tyr Thr Ala Ala Lys  Pro Gly Thr 
    1670                 1675                 1680             


Tyr Val  Ile Tyr Val Arg Phe  Gly Gly Val Asp Ile  Pro Asn Ser 
    1685                 1690                 1695             


Pro Phe  Thr Val Met Ala Thr  Asp Gly Glu Val Thr  Ala Val Glu 
    1700                 1705                 1710             


Glu Ala  Pro Val Asn Ala Cys  Pro Pro Gly Phe Arg  Pro Trp Val 
    1715                 1720                 1725             


Thr Glu  Glu Ala Tyr Val Pro  Val Ser Asp Met Asn  Gly Leu Gly 
    1730                 1735                 1740             


Phe Lys  Pro Phe Asp Leu Val  Ile Pro Phe Ala Val  Arg Lys Gly 
    1745                 1750                 1755             


Glu Ile  Thr Gly Glu Val His  Met Pro Ser Gly Lys  Thr Ala Thr 
    1760                 1765                 1770             


Pro Glu  Ile Val Asp Asn Lys  Asp Gly Thr Val Thr  Val Arg Tyr 
    1775                 1780                 1785             


Ala Pro  Thr Glu Val Gly Leu  His Glu Met His Ile  Lys Tyr Met 
    1790                 1795                 1800             


Gly Ser  His Ile Pro Glu Ser  Pro Leu Gln Phe Tyr  Val Asn Tyr 
    1805                 1810                 1815             


Pro Asn  Ser Gly Ser Val Ser  Ala Tyr Gly Pro Gly  Leu Val Tyr 
    1820                 1825                 1830             


Gly Val  Ala Asn Lys Thr Ala  Thr Phe Thr Ile Val  Thr Glu Asp 
    1835                 1840                 1845             


Ala Gly  Glu Gly Gly Leu Asp  Leu Ala Ile Glu Gly  Pro Ser Lys 
    1850                 1855                 1860             


Ala Glu  Ile Ser Cys Ile Asp  Asn Lys Asp Gly Thr  Cys Thr Val 
    1865                 1870                 1875             


Thr Tyr  Leu Pro Thr Leu Pro  Gly Asp Tyr Ser Ile  Leu Val Lys 
    1880                 1885                 1890             


Tyr Asn  Asp Lys His Ile Pro  Gly Ser Pro Phe Thr  Ala Lys Ile 
    1895                 1900                 1905             


Thr Asp  Asp Ser Arg Arg Cys  Ser Gln Val Lys Leu  Gly Ser Ala 
    1910                 1915                 1920             


Ala Asp  Phe Leu Leu Asp Ile  Ser Glu Thr Asp Leu  Ser Ser Leu 
    1925                 1930                 1935             


Thr Ala  Ser Ile Lys Ala Pro  Ser Gly Arg Asp Glu  Pro Cys Leu 
    1940                 1945                 1950             


Leu Lys  Arg Leu Pro Asn Asn  His Ile Gly Ile Ser  Phe Ile Pro 
    1955                 1960                 1965             


Arg Glu  Val Gly Glu His Leu  Val Ser Ile Lys Lys  Asn Gly Asn 
    1970                 1975                 1980             


His Val  Ala Asn Ser Pro Val  Ser Ile Met Val Val  Gln Ser Glu 
    1985                 1990                 1995             


Ile Gly  Asp Ala Arg Arg Ala  Lys Val Tyr Gly Arg  Gly Leu Ser 
    2000                 2005                 2010             


Glu Gly  Arg Thr Phe Glu Met  Ser Asp Phe Ile Val  Asp Thr Arg 
    2015                 2020                 2025             


Asp Ala  Gly Tyr Gly Gly Ile  Ser Leu Ala Val Glu  Gly Pro Ser 
    2030                 2035                 2040             


Lys Val  Asp Ile Gln Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Lys 
    2045                 2050                 2055             


Val Ser  Tyr Phe Pro Thr Val  Pro Gly Val Tyr Ile  Val Ser Thr 
    2060                 2065                 2070             


Lys Phe  Ala Asp Glu His Val  Pro Gly Ser Pro Phe  Thr Val Lys 
    2075                 2080                 2085             


Ile Ser  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Thr Ser 
    2090                 2095                 2100             


Arg Ala  Pro Ser Val Ala Thr  Val Gly Ser Ile Cys  Asp Leu Asn 
    2105                 2110                 2115             


Leu Lys  Ile Pro Glu Ile Asn  Ser Ser Asp Met Ser  Ala His Val 
    2120                 2125                 2130             


Thr Ser  Pro Ser Gly Arg Val  Thr Glu Ala Glu Ile  Val Pro Met 
    2135                 2140                 2145             


Gly Lys  Asn Ser His Cys Val  Arg Phe Val Pro Gln  Glu Met Gly 
    2150                 2155                 2160             


Val His  Thr Val Ser Val Lys  Tyr Arg Gly Gln His  Val Thr Gly 
    2165                 2170                 2175             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2180                 2185                 2190             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Gly Glu Ala 
    2195                 2200                 2205             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2210                 2215                 2220             


Gly Gly  Leu Ser Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2225                 2230                 2235             


Thr Phe  Asp Asp His Lys Asn  Gly Ser Cys Gly Val  Ser Tyr Ile 
    2240                 2245                 2250             


Ala Gln  Glu Pro Gly Asn Tyr  Glu Val Ser Ile Lys  Phe Asn Asp 
    2255                 2260                 2265             


Glu His  Ile Pro Glu Ser Pro  Tyr Leu Val Pro Val  Ile Ala Pro 
    2270                 2275                 2280             


Ser Asp  Asp Ala Arg Arg Leu  Thr Val Met Ser Leu  Gln Glu Ser 
    2285                 2290                 2295             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Ile  Arg Leu Asn 
    2300                 2305                 2310             


Gly Ala  Lys Gly Lys Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2315                 2320                 2325             


Ala Val  Glu Glu Cys His Val  Ser Glu Leu Glu Pro  Asp Lys Tyr 
    2330                 2335                 2340             


Ala Val  Arg Phe Ile Pro His  Glu Asn Gly Val His  Thr Ile Asp 
    2345                 2350                 2355             


Val Lys  Phe Asn Gly Ser His  Val Val Gly Ser Pro  Phe Lys Val 
    2360                 2365                 2370             


Arg Val  Gly Glu Pro Gly Gln  Ala Gly Asn Pro Ala  Leu Val Ser 
    2375                 2380                 2385             


Ala Tyr  Gly Thr Gly Leu Glu  Gly Gly Thr Thr Gly  Ile Gln Ser 
    2390                 2395                 2400             


Glu Phe  Phe Ile Asn Thr Thr  Arg Ala Gly Pro Gly  Thr Leu Ser 
    2405                 2410                 2415             


Val Thr  Ile Glu Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2420                 2425                 2430             


Thr Pro  Glu Gly Tyr Lys Val  Met Tyr Thr Pro Met  Ala Pro Gly 
    2435                 2440                 2445             


Asn Tyr  Leu Ile Ser Val Lys  Tyr Gly Gly Pro Asn  His Ile Val 
    2450                 2455                 2460             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Gln Arg  Leu Val Ser 
    2465                 2470                 2475             


Pro Gly  Ser Ala Asn Glu Thr  Ser Ser Ile Leu Val  Glu Ser Val 
    2480                 2485                 2490             


Thr Arg  Ser Ser Thr Glu Thr  Cys Tyr Ser Ala Ile  Pro Lys Ala 
    2495                 2500                 2505             


Ser Ser  Asp Ala Ser Lys Val  Thr Ser Lys Gly Ala  Gly Leu Ser 
    2510                 2515                 2520             


Lys Ala  Phe Val Gly Gln Lys  Ser Ser Phe Leu Val  Asp Cys Ser 
    2525                 2530                 2535             


Lys Ala  Gly Ser Asn Met Leu  Leu Ile Gly Val His  Gly Pro Thr 
    2540                 2545                 2550             


Thr Pro  Cys Glu Glu Val Ser  Met Lys His Val Gly  Asn Gln Gln 
    2555                 2560                 2565             


Tyr Asn  Val Thr Tyr Val Val  Lys Glu Arg Gly Asp  Tyr Val Leu 
    2570                 2575                 2580             


Ala Val  Lys Trp Gly Glu Glu  His Ile Pro Gly Ser  Pro Phe His 
    2585                 2590                 2595             


Val Thr  Val Pro 
    2600         


<210>  799
<211>  1463
<212>  DNA
<213>  Homosapiens

<400>  799
cagcctatga cacttttgct cctcctgaaa tctccatatc ttgcctttct caaattccaa     60

ggtagccttt gcgcaacata tcactctcca ctgactcttg tcccatcagg gcccatagtg    120

gatggctgta tgggggccat gtgactgaac tcctgatcct cgtttcagcc cactcatgtg    180

acatgcatgg agctcttcag cagggactta ctgaccagga caagagcttg agactttgag    240

gggatctgat tgtcactgca caatcaagga cagtattccc aagagtggat gttgctcaag    300

atagtccaag gaattctatg aagaaaagga ctccacagac aataaatttt ggacaccctg    360

tttcaacaca gtgcatctta gagactggtg tttgcaagta tatggagcag gaaacttcat    420

cccgaagatg gagaccccgg ggctgtcagc aggcgttaga gtcttgaagc cagagcagcg    480

ccaggatgtc acgggagctg gccccactgc tgcttctcct cctctccatc cacagcgccc    540

tggccatgag gatctgctcc ttcaacgtca ggtcctttgg ggaaagcaag caggaagaca    600

agaatgccat ggatgtcatt gtgaaggtca tcaaacgctg tgacatcata ctcgtgatgg    660

aaatcaagga cagcaacaac aggatctgcc ccatactgat ggagaagctg aacagaaatt    720

caaggagagg cataacgtac aactatgtga ttagctctcg gcttggaaga aacacatata    780

aagaacaata tgcctttctc tacaaggaaa agctggtgtc tgtgaagagg agttatcact    840

accatgacta tcaggatgga gacgcagatg tgttttccag ggagcccttt gtggtctggt    900

tccaatctcc ccacactgct gtcaaagact tcgtgattat ccccctgcac accaccccag    960

agacatccgt taaggagatc gatgagttgg ttgaggtcta cacggacgtg aaacaccgct   1020

ggaaggcgga gaatttcatt ttcatgggtg acttcaatgc cggctgcagc tacgtcccca   1080

agaaggcctg gaagaacatc cgcttgagga ctgaccccag gtttgtttgg ctgatcgggg   1140

accaagagga caccacggtg aagaagagca ccaactgtgc atatgacagg attgtgctta   1200

gaggacaaga aatcgtcagt tctgttgttc ccaagtcaaa cagtgttttt gacttccaga   1260

aagcttacaa gctgactgaa gaggaggccc tggatgtcag cgaccacttt ccagttgaat   1320

ttaaactaca gtcttcaagg gccttcacca acagcaaaaa atctgtcact ctaaggaaga   1380

aaacaaagag caaacgctcc tagacccaag ggtctcatct tattaaccat ttcttgcctc   1440

taaataaaat gtctctaaca gat                                           1463


<210>  800
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  800

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Lys Lys Ser Val Thr Leu Arg Lys Lys Thr Lys Ser Lys Arg 
    290                 295                 300                 


Ser 
305 


<210>  801
<211>  2364
<212>  DNA
<213>  Homosapiens

<400>  801
agttgccggc gttgggttgt gcgagacgct aactgtaccc tccgggttta acgctgtgag     60

gcagcagcgc gggggaactg gggataagcg ccccggagcc cccaaacaga gcgcggccgc    120

tgggggacag cgcgcggcgc cgggtcgggg cggggcggct tttctgtcgg aggacgcgaa    180

ccggcacgct gcgcctttaa ggagtccagc tgggctgggc gccggagctg ggagcggcgc    240

gggtaggagc ccggcggcag gtcccagccc ggggctagag accgagggcc ggggtccggg    300

cccggcggcg ggacccaggc ggttgaggct ggtcaggagt cagccagcct gaaagagcag    360

gatggatctt gatgtggtta acatgtttgt gactgcgggc ggcacgctgg ccatcccaat    420

cctggcattt gtggcttcat ttcttctgtg gccttcagca ctgataagaa tctattattg    480

gtactggcgg aggacattgg gcatgcaagt ccgctatgtt caccatgaag actatcagtt    540

ctgttattcc ttccggggca ggcctgggca caaaccctcc atcctcatgc tccacggatt    600

ctctgcccac aaggatatgt ggctcagtgt ggtcaagttc cttccaaaga acctgcactt    660

ggtctgcgtg gacatgccag gacatgaggg caccacccgc tcctccctgg atgacctgtc    720

catagatggg caagttaaga ggatacacca gtttgtagaa tgcccgaagc tgaacaaaaa    780

acctttccac ctggtaggca cctccatggg tggccaggtg gctggggtgt atgctgctta    840

ctacccatcg gatgtctcca gcctgtgtct cgtgtgtcct gctggcctgc agtactcaac    900

tgacaatcaa tttgtacaac ggctcaaaga actgcagggc tctgccgccg tggagaagat    960

tcccttgatc ccgtctaccc cagaagagat gagtgaaatg cttcagctct gctcctatgt   1020

ccgcttcaag gtgccccagc agatcctgca aggccttgtc gatgtccgca tccctcataa   1080

caacttctac cgaaagttgt ttttggaaat cgtcagtgag aagtccagat actctctcca   1140

tcagaacatg gacaagatca aggttccgac gcagatcatc tgggggaaac aagaccaggt   1200

gctggatgtg tctggggcag acatgttggc caagtcaatt gccaactgcc aggtggagct   1260

tctggaaaac tgtgggcact cagtagtgat ggaaagaccc aggaagacag ccaagctcat   1320

aatcgacttt ttagcttctg tgcacaacac agacaacaac aagaagctgg actgaggccc   1380

cgactgcagc ctgcattctg cacacagcat ctgctcccat cccccaagtc tgacgcagcc   1440

accactctca gggatcctgc cccaaatgcg gtcggagcgc cagtgaccct gaggaagccc   1500

gtcccttatc cctggtatcc acggttcccc agagctttgg ggaccacgcg aaaacctcca   1560

agatattttt cacaaaatag aaactcatat ggaacaaaat aagaaacccc agccatgaaa   1620

tctaccatga agtcttcaag ttcatgtcac tgagaagctt gtgcaaagca gccaccttgg   1680

accataatta aatcaaggac attttctttg agacattcct tatagttgga gactcaagat   1740

atttttgttg catcaggtgt attcccttgc atgggcagtg gcttttatag gagcattagt   1800

cctcattcgc tgaaccctgt tgtttaggtc taatttaagt tttacataga gacccatgta   1860

tgactgcagc ccattggctg caagaccagg gaggaaagtg gcaagctgta gaaaatgttt   1920

acacgcatgg aggggcattg ctctagccct cagagcgtcc ggagcagcag ggtacatggg   1980

tgggaggttc attcagcacc caccagtcag gtatgttctg agtgaaccca cagcagtcgc   2040

agaatgagca cctggcaggg tgggtttcct aggaataatt tattattttt aaaaataggc   2100

ctaataaagc aataatgttc tagacatctg tctaagtaat cagactcagg ttccacacac   2160

aagcaacaac tcgtgggcct cttttctatt tcaatgtgct actaagaacc cttggatgta   2220

acatactagt tagttaatga attctgtgaa ttctgtgaag agtaatgtga ttgaaaataa   2280

gtctaaacag ctgtaaaagt gaccacaatg acatgaaata aatttaataa gtctagatca   2340

gcaaaaaaaa aaaaaaaaaa aaaa                                          2364


<210>  802
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  802

Met Asp Leu Asp Val Val Asn Met Phe Val Thr Ala Gly Gly Thr Leu 
1               5                   10                  15      


Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 
            20                  25                  30          


Ala Leu Ile Arg Ile Tyr Tyr Trp Tyr Trp Arg Arg Thr Leu Gly Met 
        35                  40                  45              


Gln Val Arg Tyr Val His His Glu Asp Tyr Gln Phe Cys Tyr Ser Phe 
    50                  55                  60                  


Arg Gly Arg Pro Gly His Lys Pro Ser Ile Leu Met Leu His Gly Phe 
65                  70                  75                  80  


Ser Ala His Lys Asp Met Trp Leu Ser Val Val Lys Phe Leu Pro Lys 
                85                  90                  95      


Asn Leu His Leu Val Cys Val Asp Met Pro Gly His Glu Gly Thr Thr 
            100                 105                 110         


Arg Ser Ser Leu Asp Asp Leu Ser Ile Asp Gly Gln Val Lys Arg Ile 
        115                 120                 125             


His Gln Phe Val Glu Cys Pro Lys Leu Asn Lys Lys Pro Phe His Leu 
    130                 135                 140                 


Val Gly Thr Ser Met Gly Gly Gln Val Ala Gly Val Tyr Ala Ala Tyr 
145                 150                 155                 160 


Tyr Pro Ser Asp Val Ser Ser Leu Cys Leu Val Cys Pro Ala Gly Leu 
                165                 170                 175     


Gln Tyr Ser Thr Asp Asn Gln Phe Val Gln Arg Leu Lys Glu Leu Gln 
            180                 185                 190         


Gly Ser Ala Ala Val Glu Lys Ile Pro Leu Ile Pro Ser Thr Pro Glu 
        195                 200                 205             


Glu Met Ser Glu Met Leu Gln Leu Cys Ser Tyr Val Arg Phe Lys Val 
    210                 215                 220                 


Pro Gln Gln Ile Leu Gln Gly Leu Val Asp Val Arg Ile Pro His Asn 
225                 230                 235                 240 


Asn Phe Tyr Arg Lys Leu Phe Leu Glu Ile Val Ser Glu Lys Ser Arg 
                245                 250                 255     


Tyr Ser Leu His Gln Asn Met Asp Lys Ile Lys Val Pro Thr Gln Ile 
            260                 265                 270         


Ile Trp Gly Lys Gln Asp Gln Val Leu Asp Val Ser Gly Ala Asp Met 
        275                 280                 285             


Leu Ala Lys Ser Ile Ala Asn Cys Gln Val Glu Leu Leu Glu Asn Cys 
    290                 295                 300                 


Gly His Ser Val Val Met Glu Arg Pro Arg Lys Thr Ala Lys Leu Ile 
305                 310                 315                 320 


Ile Asp Phe Leu Ala Ser Val His Asn Thr Asp Asn Asn Lys Lys Leu 
                325                 330                 335     


Asp 
    


<210>  803
<211>  1567
<212>  DNA
<213>  Homosapiens

<400>  803
gaattcggca cgagggagaa gccaaacgta aagacaccag gagtttctcg ggcccagctg     60

tggctgctgc cggggagccc caagccttgg cggtccttgc tgcgaatagg agtctggtca    120

ggcgtcaggc tagtccgacg aagagtgggt gtgatcagca ctggaaaaga tgcctgcccc    180

tgctgccaca tatgaaagag tagtttacaa aaacccttcc gagtaccact acatgaaagt    240

ctgcctagaa tttcaagatt gtggagttgg actgaatgct gcacagttca aacagctgct    300

tatttcggct gtgaaggacc tgtttgggga ggttgatgcc gccttacctt tggacatcct    360

aacctatgaa gagaagacct tgtcagccat cttgagaata tgtagcagtg gtcttgtcaa    420

attgtggagc tctttgaccc tgttaggatc ctataaaggc aaaaaatgtg ctttccgggt    480

gattcaggtt tctccatttc ttcttgcatt atctggtaat agtagggaac tagtattgga    540

ttgaatgaat agtcttccat tttggaaacg ttcatccact ctcatattta ttttttcggt    600

gcctgcatgt ttgaagactg aagcaggcta aaagctcttg atgaaatttg agggtgctga    660

agatgttccc actaatttcc agccatcacc tttggtgggg tgggcttcgg aggacagtct    720

gtctgaacct gccagtgctg accctgcagc actttcagca tatgcacatc aaagttggag    780

accgcgctga acttaggagg gccttcacac agactgatgt ggctaccttc tcagaattaa    840

caggggatgt taatcctttg catttgaatg aagactttgc aaaacacacc aagtttggaa    900

atacaattgt acatggagtt ttgatcaacg gacttatctc agctctccta ggaactaaaa    960

tgccagggcc aggctgtgta tttctttccc aggaaattag ctttccagcc cctttatata   1020

ttggagaagt tgttttagct tctgcagaag tgaaaaagct gaagcggttc attgctatta   1080

ttgcagtgtc atgttctgta atagaaagta aaaagactgt tatggaaggc tgggttaaag   1140

ttatggttcc agaagcttcc aaatcctgaa atagatgttt taaagatgca acctcaaaca   1200

ccaatgctgt tgttaaagag cctatgggga attgctgctc tttaccaaag aatggttgat   1260

aggcccagaa gcccatgtta gttaggggaa gggagcagga agagggttgt tcaaatgccc   1320

actttccagt ttggccttat gctttatgca gacttgagtg tatgcaggat ttcattatct   1380

gcctgggttt ttttgtttgt tttttgtttt ttaattcaag aagtaggctg ggcccggtgg   1440

ctcatgcctg taatcctggc actttgggag gctgcggcag gcggatcact tgaggtcagg   1500

agtccaagac cagcctggcc aacatggtga aaccccatct ctaccaaaaa aaaaaaaaaa   1560

aaaaaaa                                                             1567


<210>  804
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  804

Met Pro Ala Pro Ala Ala Thr Tyr Glu Arg Val Val Tyr Lys Asn Pro 
1               5                   10                  15      


Ser Glu Tyr His Tyr Met Lys Val Cys Leu Glu Phe Gln Asp Cys Gly 
            20                  25                  30          


Val Gly Leu Asn Ala Ala Gln Phe Lys Gln Leu Leu Ile Ser Ala Val 
        35                  40                  45              


Lys Asp Leu Phe Gly Glu Val Asp Ala Ala Leu Pro Leu Asp Ile Leu 
    50                  55                  60                  


Thr Tyr Glu Glu Lys Thr Leu Ser Ala Ile Leu Arg Ile Cys Ser Ser 
65                  70                  75                  80  


Gly Leu Val Lys Leu Trp Ser Ser Leu Thr Leu Leu Gly Ser Tyr Lys 
                85                  90                  95      


Gly Lys Lys Cys Ala Phe Arg Val Ile Gln Val Ser Pro Phe Leu Leu 
            100                 105                 110         


Ala Leu Ser Gly Asn Ser Arg Glu Leu Val Leu Asp 
        115                 120                 


<210>  805
<211>  2050
<212>  DNA
<213>  Homosapiens

<400>  805
gtgttgacag cggcggcggt ggaaccgggc gggcggcggg agtcggcgcc tcgggttcct     60

acctcgcgtc cctaggcggc ggcggccggg cgtcccggga tggccttcat ggagaagccg    120

ccagccggca aggtgctgct ggacgacacg gtgccgctga cagcagccat cgaggcgagc    180

cagagcctgc agtcccacac ggaatatatt attcgagtgc aaagaggaat ttctgtggaa    240

aacagctggc agattgttag aagatacagt gactttgatt tgcttaacaa cagcttacag    300

attgcaggcc taagtctacc tcttcctccc aaaaaattga ttggtaacat ggatcgtgaa    360

ttcatagctg aaaggcagaa aggtcttcag aactatctca acgtgatcac aacaaatcat    420

atcttgtcta attgtgagct ggttaagaag tttttagatc caaacaacta ttccgcaaac    480

tatactgaga ttgccttgca acaggtttcc atgttcttcc gatcagaacc aaagtgggag    540

gtggtggaac ctttgaaaga cataggttgg agaataagga agaaatattt cttgatgaag    600

attaaaaatc agccaaagga acggctagtg ttaagctggg ctgaccttgg cccagacaag    660

tatttgtcag ataaagattt tcagtgtcta atcaaacttc tgccttcttg tttgcaccct    720

tacatctatc gggttacctt tgccacagct aatgaatcct cagcgttgct aattaggatg    780

tttaacgaaa agggaacatt gaaggatctg atctacaagg caaaaccaaa agacccattt    840

ctaaagaagt actgcaaccc taagaagatt cagggcctgg aactccagca aataaaaaca    900

tatggacggc aaatattaga ggtactgaag tttcttcatg acaagggatt cccttatggg    960

catcttcacg cctccaatgt gatgctcgat ggggacactt gccggctgct ggaccttgag   1020

aattccttat tgggcctgcc ttccttctac cgatcttatt tttcacaatt caggaaaatc   1080

aatacattgg aaagtgtgga tgtccactgc tttggccact tactgtatga aatgacttat   1140

ggacgaccgc cagactcggt gcctgtggac tccttccctc ctgccccgtc catggctgtg   1200

gtggccgtgt tggagtctac gctgtcttgt gaagcctgta aaaatggcat gcctaccatc   1260

tcccggctct tacagatgcc attattcagc gatgttttac taaccacttc tgaaaaacca   1320

cagtttaaga tccctacaaa gttaaaagag gcattgagaa ttgccaaaga atgtatagag   1380

aagagactaa ttgaggaaca gaaacagatt caccagcatc gaagactgac aagagctcag   1440

tcccaccatg gatctgagga ggaaagaaaa aaaagaaaga ttttagctcg aaagaagtca   1500

aaacgatctg ctcttgaaaa tagtgaagag cattcagcga agtacagcaa ctccaataat   1560

tcagcaggat ctggggccag ctcacctctc acgtccccgt catcgccaac tccaccctct   1620

acatcaggga tatctgcatt acctccacct cctccacctc caccaccacc agcagctccc   1680

ttgcctcctg cgagcaccga ggcacctgcc cagctctcgt ctcaggctgt gaatggcatg   1740

agccgagggg ccttgctcag ctccatccag aatttccaaa aaggaacttt gaggaaagcc   1800

aaaacctgtg atcacagtgc tccgaagatc ggctgaagct tcctgtttac acttggaggg   1860

aaaagttctt ttttattcct actcacccct accccccaaa ctaccctctt cctgggaaag   1920

taattgctga gccagtacag ccacaaacag tactattttg cagatgctca tgtaagcagc   1980

ttttcgagag aaataattct ttaagcagaa taaagttagg ctggcatgca aaaaaaaaaa   2040

aaaaaaaaaa                                                          2050


<210>  806
<211>  578
<212>  PRT
<213>  Homosapiens

<400>  806

Met Ala Phe Met Glu Lys Pro Pro Ala Gly Lys Val Leu Leu Asp Asp 
1               5                   10                  15      


Thr Val Pro Leu Thr Ala Ala Ile Glu Ala Ser Gln Ser Leu Gln Ser 
            20                  25                  30          


His Thr Glu Tyr Ile Ile Arg Val Gln Arg Gly Ile Ser Val Glu Asn 
        35                  40                  45              


Ser Trp Gln Ile Val Arg Arg Tyr Ser Asp Phe Asp Leu Leu Asn Asn 
    50                  55                  60                  


Ser Leu Gln Ile Ala Gly Leu Ser Leu Pro Leu Pro Pro Lys Lys Leu 
65                  70                  75                  80  


Ile Gly Asn Met Asp Arg Glu Phe Ile Ala Glu Arg Gln Lys Gly Leu 
                85                  90                  95      


Gln Asn Tyr Leu Asn Val Ile Thr Thr Asn His Ile Leu Ser Asn Cys 
            100                 105                 110         


Glu Leu Val Lys Lys Phe Leu Asp Pro Asn Asn Tyr Ser Ala Asn Tyr 
        115                 120                 125             


Thr Glu Ile Ala Leu Gln Gln Val Ser Met Phe Phe Arg Ser Glu Pro 
    130                 135                 140                 


Lys Trp Glu Val Val Glu Pro Leu Lys Asp Ile Gly Trp Arg Ile Arg 
145                 150                 155                 160 


Lys Lys Tyr Phe Leu Met Lys Ile Lys Asn Gln Pro Lys Glu Arg Leu 
                165                 170                 175     


Val Leu Ser Trp Ala Asp Leu Gly Pro Asp Lys Tyr Leu Ser Asp Lys 
            180                 185                 190         


Asp Phe Gln Cys Leu Ile Lys Leu Leu Pro Ser Cys Leu His Pro Tyr 
        195                 200                 205             


Ile Tyr Arg Val Thr Phe Ala Thr Ala Asn Glu Ser Ser Ala Leu Leu 
    210                 215                 220                 


Ile Arg Met Phe Asn Glu Lys Gly Thr Leu Lys Asp Leu Ile Tyr Lys 
225                 230                 235                 240 


Ala Lys Pro Lys Asp Pro Phe Leu Lys Lys Tyr Cys Asn Pro Lys Lys 
                245                 250                 255     


Ile Gln Gly Leu Glu Leu Gln Gln Ile Lys Thr Tyr Gly Arg Gln Ile 
            260                 265                 270         


Leu Glu Val Leu Lys Phe Leu His Asp Lys Gly Phe Pro Tyr Gly His 
        275                 280                 285             


Leu His Ala Ser Asn Val Met Leu Asp Gly Asp Thr Cys Arg Leu Leu 
    290                 295                 300                 


Asp Leu Glu Asn Ser Leu Leu Gly Leu Pro Ser Phe Tyr Arg Ser Tyr 
305                 310                 315                 320 


Phe Ser Gln Phe Arg Lys Ile Asn Thr Leu Glu Ser Val Asp Val His 
                325                 330                 335     


Cys Phe Gly His Leu Leu Tyr Glu Met Thr Tyr Gly Arg Pro Pro Asp 
            340                 345                 350         


Ser Val Pro Val Asp Ser Phe Pro Pro Ala Pro Ser Met Ala Val Val 
        355                 360                 365             


Ala Val Leu Glu Ser Thr Leu Ser Cys Glu Ala Cys Lys Asn Gly Met 
    370                 375                 380                 


Pro Thr Ile Ser Arg Leu Leu Gln Met Pro Leu Phe Ser Asp Val Leu 
385                 390                 395                 400 


Leu Thr Thr Ser Glu Lys Pro Gln Phe Lys Ile Pro Thr Lys Leu Lys 
                405                 410                 415     


Glu Ala Leu Arg Ile Ala Lys Glu Cys Ile Glu Lys Arg Leu Ile Glu 
            420                 425                 430         


Glu Gln Lys Gln Ile His Gln His Arg Arg Leu Thr Arg Ala Gln Ser 
        435                 440                 445             


His His Gly Ser Glu Glu Glu Arg Lys Lys Arg Lys Ile Leu Ala Arg 
    450                 455                 460                 


Lys Lys Ser Lys Arg Ser Ala Leu Glu Asn Ser Glu Glu His Ser Ala 
465                 470                 475                 480 


Lys Tyr Ser Asn Ser Asn Asn Ser Ala Gly Ser Gly Ala Ser Ser Pro 
                485                 490                 495     


Leu Thr Ser Pro Ser Ser Pro Thr Pro Pro Ser Thr Ser Gly Ile Ser 
            500                 505                 510         


Ala Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Ala Pro Leu 
        515                 520                 525             


Pro Pro Ala Ser Thr Glu Ala Pro Ala Gln Leu Ser Ser Gln Ala Val 
    530                 535                 540                 


Asn Gly Met Ser Arg Gly Ala Leu Leu Ser Ser Ile Gln Asn Phe Gln 
545                 550                 555                 560 


Lys Gly Thr Leu Arg Lys Ala Lys Thr Cys Asp His Ser Ala Pro Lys 
                565                 570                 575     


Ile Gly 
        


<210>  807
<211>  615
<212>  DNA
<213>  Homosapiens

<400>  807
gcccttggcc tgtttctatg aagctccctg gtgagaagag tttgtctttt cctttgcacc     60

ccgaagcccc tgcctgggct aaaaacgtgc aggaatgcgg catttggaga aattacacct    120

ctgagctgcc aggatatatt caaacagcca agaacagaag ttggcccaac tgggacgcat    180

ccgtggagca gcaaatatgc acactcctgg cagtcatgca agcaagatgg tcaacgtcag    240

atacacaagg ctggcttgag cagtgttcac tggggaaaat tcatggacag gggagcagaa    300

acagaagaaa aaccacccac cccaatgtct tgcacactgc aacaactctg tgaacactgg    360

tcattattct actgttgtta ttggtgctct ttactggcca aagctcagtg ggaggactac    420

tatctaacac aagtgccctg caggacagaa agaacaagag tgctagagct tttgtgcatc    480

tgggccattt tttcatttga catatgaaga atctaagaac ctgcaaggtg gaagtgacct    540

gttcaaatag cagcaaagtc aaaagcagat gtagctctct atctctgagc ctctaataaa    600

attaatctaa atagt                                                     615


<210>  808
<211>  111
<212>  PRT
<213>  Homosapiens

<400>  808

Met Lys Leu Pro Gly Glu Lys Ser Leu Ser Phe Pro Leu His Pro Glu 
1               5                   10                  15      


Ala Pro Ala Trp Ala Lys Asn Val Gln Glu Cys Gly Ile Trp Arg Asn 
            20                  25                  30          


Tyr Thr Ser Glu Leu Pro Gly Tyr Ile Gln Thr Ala Lys Asn Arg Ser 
        35                  40                  45              


Trp Pro Asn Trp Asp Ala Ser Val Glu Gln Gln Ile Cys Thr Leu Leu 
    50                  55                  60                  


Ala Val Met Gln Ala Arg Trp Ser Thr Ser Asp Thr Gln Gly Trp Leu 
65                  70                  75                  80  


Glu Gln Cys Ser Leu Gly Lys Ile His Gly Gln Gly Ser Arg Asn Arg 
                85                  90                  95      


Arg Lys Thr Thr His Pro Asn Val Leu His Thr Ala Thr Thr Leu 
            100                 105                 110     


<210>  809
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  809
ctcagcttgc gccgccgccg ccgccgccgc cgccgcgcac gccatgggag ccgtgactga     60

cgacgaagtt atacggaagc gtctcctcat tgatggagat ggtgctggag gtgatcggag    120

aattaatctg ctagtgaaga gtttcattaa atggtgcaac tctgggtccc aggaggaggg    180

atatagccag taccaacgta tgctgagcac gctgtctcaa tgtgaatttt caatgggcaa    240

aactttacta gtatatgata tgaatctcag agaaatggaa aattatgaaa aaatttacaa    300

ggaaatagaa tgtagcatag ctggagcaca tgaaaaaatt gctgagtgca aaaagcaaat    360

tcttcaagca aaacgaatac gaaaaaatcg ccaagaatat gatgctttgg caaaagtgat    420

tcagcaccat ccagacaggc atgagacatt aaaggaacta gaggctctgg gaaaagaatt    480

agagcatctt tcacacatta aagaaagtgt tgaagataag ctggaattga gacggaaaca    540

gtttcatgtt cttcttagta ccatccatga acttcagcaa acattggaaa atgatgaaaa    600

actctcagag gtagaagaag ctcaggaagc aagcatggaa tcagatccta agccatagac    660

aggctaattg cccaccactc ccaggaatat tgaaatagct acatgaccat aatgtgttta    720

aaatgtggta tgctcttgag atatttaaag ttttggcagt aaaatactct gtttttaagt    780

atgaatgtat ttcattcata tttcctctca caaaggaaaa tgacttcagt atagatttgt    840

ttttattaaa atgcattttt tattcttaag tggtaggaag caacatccaa aaatgcttaa    900

taaaatgctt ttaagctgca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    960

aaa                                                                  963


<210>  810
<211>  204
<212>  PRT
<213>  Homosapiens

<400>  810

Met Gly Ala Val Thr Asp Asp Glu Val Ile Arg Lys Arg Leu Leu Ile 
1               5                   10                  15      


Asp Gly Asp Gly Ala Gly Gly Asp Arg Arg Ile Asn Leu Leu Val Lys 
            20                  25                  30          


Ser Phe Ile Lys Trp Cys Asn Ser Gly Ser Gln Glu Glu Gly Tyr Ser 
        35                  40                  45              


Gln Tyr Gln Arg Met Leu Ser Thr Leu Ser Gln Cys Glu Phe Ser Met 
    50                  55                  60                  


Gly Lys Thr Leu Leu Val Tyr Asp Met Asn Leu Arg Glu Met Glu Asn 
65                  70                  75                  80  


Tyr Glu Lys Ile Tyr Lys Glu Ile Glu Cys Ser Ile Ala Gly Ala His 
                85                  90                  95      


Glu Lys Ile Ala Glu Cys Lys Lys Gln Ile Leu Gln Ala Lys Arg Ile 
            100                 105                 110         


Arg Lys Asn Arg Gln Glu Tyr Asp Ala Leu Ala Lys Val Ile Gln His 
        115                 120                 125             


His Pro Asp Arg His Glu Thr Leu Lys Glu Leu Glu Ala Leu Gly Lys 
    130                 135                 140                 


Glu Leu Glu His Leu Ser His Ile Lys Glu Ser Val Glu Asp Lys Leu 
145                 150                 155                 160 


Glu Leu Arg Arg Lys Gln Phe His Val Leu Leu Ser Thr Ile His Glu 
                165                 170                 175     


Leu Gln Gln Thr Leu Glu Asn Asp Glu Lys Leu Ser Glu Val Glu Glu 
            180                 185                 190         


Ala Gln Glu Ala Ser Met Glu Ser Asp Pro Lys Pro 
        195                 200                 


<210>  811
<211>  4416
<212>  DNA
<213>  Homosapiens

<400>  811
gaaaaagggt gaaagagaaa cttggcgacc tcccggagga gttcgcgaag cgaccaggag     60

cgtgttgcca tcgtcctcac ccggcaccca attccaccac agagtcggga tttcgtcggt    120

gatcgtgatg gggtgctttt atttttctct ttgattttca aaaaatgtct atgtgactgt    180

ccctatctta aggggaagtt gaaagtgggg gcgggggtgc tcaatgagaa acgttgcctt    240

gtgtgtagtt gtttggagca cactgcaaat tatattggca tctctttcca aaagtcactt    300

tgattcaact tcgatagctt tctcgtaaat ggcacgttta ggtggtgaga ggtggatgag    360

gaaacaggca ccagtgcagc tgatttgacc tccagtggga tagatacgat tagcaccagg    420

atcgtgtctc attttgaacc cagatctgaa cagaattaag acgaacgagc tttcacaatt    480

gcagcagatg aagatccatt ggtaaattga tcaggatttt tggcctaccc tccaaagaaa    540

aggagcggaa agaatgtcgg agcgggccgc ggatgacgtc aggggggagc cgcgccgcgc    600

ggcggcggcg gcgggcggag cagcggccgc ggccgcccgg cagcagcagc agcagcagca    660

gcagcagcag ccgccgcctc cgcagcccca gcggcagcag cacccgccac cgccgccacg    720

gcgcacacgg ccggaggacg gcgggcccgg cgccgcctcc acctcggccg ccgcaatggc    780

gacggtcggg gagcgcaggc ctctgcccag tcctgaagtg atgctgggac agtcgtggaa    840

tctgtgggtt gaggcttcca aacttcctgg gaaggacggg acagaattgg acgaaagttt    900

caaggagttt gggaaaaacc gcgaagtcat ggggctctgt cgggaagaca tgccaatatt    960

tggtttctgt ccagcccatg atgatttcta cttggtggtg tgtaacgact gtaatcaggt   1020

tgtcaaaccg caggcatttc aatcacatta tgaaagaaga catagctcat ccagcaagcc   1080

gcctttggcc gttcctccca cttcagtatt ttccttcttc ccttctctgt ccaaaagcaa   1140

aggaggcagt gcaagtggaa gcaaccgttc ttccagtgga ggtgttctta gcgcatcctc   1200

atcaagttcc aagttgttga aatcacccaa agagaaactg cagctcaggg ggaacaccag   1260

gccaatgcat cccattcagc aaagtagagt tccccatggt agaatcatga caccctctgt   1320

gaaagtggaa aagattcatc cgaaaatgga tggcacacta ctgaaatctg cggtggggcc   1380

aacctgtcct gctactgtga gttccttagt caagcctggc cttaactgcc cctcaatacc   1440

aaagccaacc ttgccttcac ctggacagat tctgaatggc aaagggcttc ctgcaccgcc   1500

cactctggaa aagaaacctg aagacaattc caataatagg aaatttttaa ataagagatt   1560

atcagaaaga gagtttgatc ctgacatcca ctgtggggtt attgatctcg acaccaagaa   1620

gccctgcacc cggtctttga catgcaagac acattcctta acccagcgca gggctgtcca   1680

gggtagaaga aaacgatttg atgtgttatt agccgagcac aaaaacaaaa ccagggaaaa   1740

ggaattgatt cgccatccgg actctcagca accaccgcag cctctcaggg acccgcatcc   1800

cgcccctcct agaacgtcac aggagccgca ccaaaaccct cacggagtga ttccttccga   1860

atcaaagcct tttgtagcta gtaaacctaa acctcacacc cccagtcttc caaggcctcc   1920

aggctgccct gctcagcaag gtgggagtgc ccccattgac cctcctccag tccatgaatc   1980

tccacaccct cccctgcctg ccactgagcc agcttctcgg ttatccagtg aggagggcga   2040

aggcgatgac aaagaagagt ctgttgaaaa actggactgt cattattcag gtcatcatcc   2100

tcagccagca tctttttgca catttgggag ccggcagata ggaagaggct attacgtgtt   2160

tgactccagg tggaatcgac ttcgctgcgc cctcaacctc atggtggaga agcatctgaa   2220

tgcacagcta tggaagaaaa tcccaccagt gcccagtacc acctcaccca tctccacacg   2280

tattcctcac cggacaaact ctgtgccgac atcacaatgt ggagtcagct atctggcagc   2340

agccaccgtc tctacatccc cagtcctgct ctcatctacc tgcatctccc caaatagcaa   2400

atcggtacca gctcatggaa ccacactaaa tgcacagcct gctgcttcag gggcgatgga   2460

tcctgtgtgc agtatgcaat ccagacaagt gtcctcttca tcctcatccc cttccacgcc   2520

ctctggcctt tcctcggttc cttcctcccc catgtccagg aaacctcaga aattgaaatc   2580

cagcaaatct ttgaggccca aggagtcttc tggtaacagc actaactgtc aaaatgccag   2640

tagcagtacc agtggcggct caggaaagaa acgcaaaaac agttccccac tgttggttca   2700

ctcttcctcc tcctcttcct cctcctcctc ttcttctcat tccatggagt cttttaggaa   2760

aaactgtgtg gctcactctg ggcctcccta cccctcaacg gtaacatctt cccatagcat   2820

cggcctcaac tgtgtgacga ataaagcaaa tgcggtgaac gtccggcatg accagtcagg   2880

gaggggcccc cccaccggga gccctgctga atccatcaag aggatgagtg tgatggtgaa   2940

cagcagtgat tctactcttt ctcttgggcc attcattcac cagtccaatg aactgcctgt   3000

caactcccac ggcagttttt cccactcaca cactcctcta gacaaactca taggaaagaa   3060

aagaaagtgc tcacccagct cgagcagcat caacaacagc agcagcaaac ccacaaaggt   3120

tgccaaagtg ccagccgtga acaatgtcca catgaaacac acaggcacca tcccaggggc   3180

acaaggactg atgaacagtt ccctccttca tcagccaaag gcacgtccct gacagctgaa   3240

aatagcacgg ggaggaataa tgcggacact tttgaggaca agttacacct ccactcagca   3300

ctctggactc cacgatgcct ttgagtctgt tttcccaacc tcctgtgggc ctcaagggta   3360

gaaacctgcc gggctgttgt tttaacgagg atttccctga agctatgtct ctagcagtga   3420

gtactcataa aggacactgg atcaagttca gccaccgaat tgcttttatc agtgttaaag   3480

tggtctgaac tgcttgctac caatctgtga gaagtttttg tttttgtttt gttttttaac   3540

ttgcagtata tcacagagcc actcttcaag tagattggct gggcaaaaga atgttttggc   3600

aagagcgtta ctgtagacct ttctccctcc ttccttttac taccattttt ttttaacact   3660

gtcatctgta ggtcactctc cagcagttag gcaccttaac tggagaccag aaaccttcca   3720

gagaacacag ggctgcatcc cgagcaaccc tctgaagaag ggaattaggc tttagatttt   3780

gatagcaatg ttccaggaat gaaatataga tgttagccca agacaccatg acaaaatagc   3840

ccagcctttt gagagtaatt tgggaaaaga agctgtcaga agtttctaac ttacaaactg   3900

gtttgaaatt tttgatgccc agacagcaag tataaatcat tttggaggct tacttttcat   3960

gatacaaaag caattctgtg tgattttttt ttttaagaag aaagaaaatg caagctagtt   4020

ttgagaaagg aaggccaaat tgggtcgggg gagggtggga gtgaggaagt taaaatcact   4080

atagggagaa aaaacttttt tcaagatttc caaagagatg aaattttctt aatcctttta   4140

agttttcata gtaaacagta tggcagattg ggttggttgt cctacctggt ctatttttaa   4200

aagtcacctt ttaaagtgac attattagat acacttaaat gtttccaagg cactctctac   4260

attacccttg tttttctctt tggatactgt cctgggacta agtgtagatt tctgcttcaa   4320

gcacttctgg cattgtgtgt ttttgtatgc actccccttc atgccacttc agatgtttat   4380

ttggatgtgg ttggggacga gagcagacac caagga                             4416


<210>  812
<211>  892
<212>  PRT
<213>  Homosapiens

<400>  812

Met Ser Glu Arg Ala Ala Asp Asp Val Arg Gly Glu Pro Arg Arg Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Arg Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Gln Pro Gln Arg Gln 
        35                  40                  45              


Gln His Pro Pro Pro Pro Pro Arg Arg Thr Arg Pro Glu Asp Gly Gly 
    50                  55                  60                  


Pro Gly Ala Ala Ser Thr Ser Ala Ala Ala Met Ala Thr Val Gly Glu 
65                  70                  75                  80  


Arg Arg Pro Leu Pro Ser Pro Glu Val Met Leu Gly Gln Ser Trp Asn 
                85                  90                  95      


Leu Trp Val Glu Ala Ser Lys Leu Pro Gly Lys Asp Gly Thr Glu Leu 
            100                 105                 110         


Asp Glu Ser Phe Lys Glu Phe Gly Lys Asn Arg Glu Val Met Gly Leu 
        115                 120                 125             


Cys Arg Glu Asp Met Pro Ile Phe Gly Phe Cys Pro Ala His Asp Asp 
    130                 135                 140                 


Phe Tyr Leu Val Val Cys Asn Asp Cys Asn Gln Val Val Lys Pro Gln 
145                 150                 155                 160 


Ala Phe Gln Ser His Tyr Glu Arg Arg His Ser Ser Ser Ser Lys Pro 
                165                 170                 175     


Pro Leu Ala Val Pro Pro Thr Ser Val Phe Ser Phe Phe Pro Ser Leu 
            180                 185                 190         


Ser Lys Ser Lys Gly Gly Ser Ala Ser Gly Ser Asn Arg Ser Ser Ser 
        195                 200                 205             


Gly Gly Val Leu Ser Ala Ser Ser Ser Ser Ser Lys Leu Leu Lys Ser 
    210                 215                 220                 


Pro Lys Glu Lys Leu Gln Leu Arg Gly Asn Thr Arg Pro Met His Pro 
225                 230                 235                 240 


Ile Gln Gln Ser Arg Val Pro His Gly Arg Ile Met Thr Pro Ser Val 
                245                 250                 255     


Lys Val Glu Lys Ile His Pro Lys Met Asp Gly Thr Leu Leu Lys Ser 
            260                 265                 270         


Ala Val Gly Pro Thr Cys Pro Ala Thr Val Ser Ser Leu Val Lys Pro 
        275                 280                 285             


Gly Leu Asn Cys Pro Ser Ile Pro Lys Pro Thr Leu Pro Ser Pro Gly 
    290                 295                 300                 


Gln Ile Leu Asn Gly Lys Gly Leu Pro Ala Pro Pro Thr Leu Glu Lys 
305                 310                 315                 320 


Lys Pro Glu Asp Asn Ser Asn Asn Arg Lys Phe Leu Asn Lys Arg Leu 
                325                 330                 335     


Ser Glu Arg Glu Phe Asp Pro Asp Ile His Cys Gly Val Ile Asp Leu 
            340                 345                 350         


Asp Thr Lys Lys Pro Cys Thr Arg Ser Leu Thr Cys Lys Thr His Ser 
        355                 360                 365             


Leu Thr Gln Arg Arg Ala Val Gln Gly Arg Arg Lys Arg Phe Asp Val 
    370                 375                 380                 


Leu Leu Ala Glu His Lys Asn Lys Thr Arg Glu Lys Glu Leu Ile Arg 
385                 390                 395                 400 


His Pro Asp Ser Gln Gln Pro Pro Gln Pro Leu Arg Asp Pro His Pro 
                405                 410                 415     


Ala Pro Pro Arg Thr Ser Gln Glu Pro His Gln Asn Pro His Gly Val 
            420                 425                 430         


Ile Pro Ser Glu Ser Lys Pro Phe Val Ala Ser Lys Pro Lys Pro His 
        435                 440                 445             


Thr Pro Ser Leu Pro Arg Pro Pro Gly Cys Pro Ala Gln Gln Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ile Asp Pro Pro Pro Val His Glu Ser Pro His Pro Pro 
465                 470                 475                 480 


Leu Pro Ala Thr Glu Pro Ala Ser Arg Leu Ser Ser Glu Glu Gly Glu 
                485                 490                 495     


Gly Asp Asp Lys Glu Glu Ser Val Glu Lys Leu Asp Cys His Tyr Ser 
            500                 505                 510         


Gly His His Pro Gln Pro Ala Ser Phe Cys Thr Phe Gly Ser Arg Gln 
        515                 520                 525             


Ile Gly Arg Gly Tyr Tyr Val Phe Asp Ser Arg Trp Asn Arg Leu Arg 
    530                 535                 540                 


Cys Ala Leu Asn Leu Met Val Glu Lys His Leu Asn Ala Gln Leu Trp 
545                 550                 555                 560 


Lys Lys Ile Pro Pro Val Pro Ser Thr Thr Ser Pro Ile Ser Thr Arg 
                565                 570                 575     


Ile Pro His Arg Thr Asn Ser Val Pro Thr Ser Gln Cys Gly Val Ser 
            580                 585                 590         


Tyr Leu Ala Ala Ala Thr Val Ser Thr Ser Pro Val Leu Leu Ser Ser 
        595                 600                 605             


Thr Cys Ile Ser Pro Asn Ser Lys Ser Val Pro Ala His Gly Thr Thr 
    610                 615                 620                 


Leu Asn Ala Gln Pro Ala Ala Ser Gly Ala Met Asp Pro Val Cys Ser 
625                 630                 635                 640 


Met Gln Ser Arg Gln Val Ser Ser Ser Ser Ser Ser Pro Ser Thr Pro 
                645                 650                 655     


Ser Gly Leu Ser Ser Val Pro Ser Ser Pro Met Ser Arg Lys Pro Gln 
            660                 665                 670         


Lys Leu Lys Ser Ser Lys Ser Leu Arg Pro Lys Glu Ser Ser Gly Asn 
        675                 680                 685             


Ser Thr Asn Cys Gln Asn Ala Ser Ser Ser Thr Ser Gly Gly Ser Gly 
    690                 695                 700                 


Lys Lys Arg Lys Asn Ser Ser Pro Leu Leu Val His Ser Ser Ser Ser 
705                 710                 715                 720 


Ser Ser Ser Ser Ser Ser Ser Ser His Ser Met Glu Ser Phe Arg Lys 
                725                 730                 735     


Asn Cys Val Ala His Ser Gly Pro Pro Tyr Pro Ser Thr Val Thr Ser 
            740                 745                 750         


Ser His Ser Ile Gly Leu Asn Cys Val Thr Asn Lys Ala Asn Ala Val 
        755                 760                 765             


Asn Val Arg His Asp Gln Ser Gly Arg Gly Pro Pro Thr Gly Ser Pro 
    770                 775                 780                 


Ala Glu Ser Ile Lys Arg Met Ser Val Met Val Asn Ser Ser Asp Ser 
785                 790                 795                 800 


Thr Leu Ser Leu Gly Pro Phe Ile His Gln Ser Asn Glu Leu Pro Val 
                805                 810                 815     


Asn Ser His Gly Ser Phe Ser His Ser His Thr Pro Leu Asp Lys Leu 
            820                 825                 830         


Ile Gly Lys Lys Arg Lys Cys Ser Pro Ser Ser Ser Ser Ile Asn Asn 
        835                 840                 845             


Ser Ser Ser Lys Pro Thr Lys Val Ala Lys Val Pro Ala Val Asn Asn 
    850                 855                 860                 


Val His Met Lys His Thr Gly Thr Ile Pro Gly Ala Gln Gly Leu Met 
865                 870                 875                 880 


Asn Ser Ser Leu Leu His Gln Pro Lys Ala Arg Pro 
                885                 890         


<210>  813
<211>  1308
<212>  DNA
<213>  Homosapiens

<400>  813
gtcagccgct gtccccttag ccgcgatgcc gctggagaac ctggaggagg agggtctgcc     60

caagaacccc gacttgcgta tcgcgcagct gcgcttcctg ctcagcctgc ccgagcaccg    120

cggagacgct gccgtgcgcg acgagctgat ggcggccgtc cgcgataaca acatggctcc    180

ttactatgaa gccttgtgca aatccctcga ctggcagata gacgtggacc tactcaataa    240

aatgaagaag gcaaatgaag atgagttgaa gcgtttggat gaggagctgg aagatgcaga    300

gaagaatcta ggagagagcg aaattcgcga tgcaatgatg gcaaaggccg agtacctctg    360

ccggataggt gacaaagagg gagctctgac agcctttcgc aagacatatg acaaaactgt    420

ggccctgggt caccgattgg atattgtatt ctatctcctt aggattggct tattttatat    480

ggataatgat ctcatcacac gaaacacaga aaaggccaaa agcttaatag aagaaggagg    540

agactgggac aggagaaacc gcctaaaagt gtatcagggt ctttattgtg tggctattcg    600

tgatttcaaa caggcagctg aactcttcct tgacactgtt tcaacattta catcctatga    660

actcatggat tataaaacat ttgtgactta tactgtctat gtcagtatga ttgccttaga    720

aagaccagat ctcagggaaa aggtcattaa aggagcagag attcttgaag tgttgcacag    780

tcttccagca gttcggcagt atctgttttc actctatgaa tgccgttact ctgttttctt    840

ccaatcatta gcggttgtgg aacaggaaat gaaaaaggac tggctttttg cccctcatta    900

tcgatactat gtaagagaaa tgagaattca tgcatacagt cagctgctgg aatcatatag    960

gtcattaacc cttggctata tggcagaagc gtttggtgtt ggtgtggaat tcattgatca   1020

ggaactgtcc aggtttattg ctgccgggag actacactgc aaaatagata aagtgaatga   1080

aatagtagaa accaacagac ctgatagcaa gaactggcag taccaagaaa ctatcaagaa   1140

aggagatctg ctactaaaca gagttcaaaa actttccaga gtaattaata tgtaaagcca   1200

tgtaactaac aaaggatttg ctttagagat aattatttgg aatttttata gcttacttca   1260

caatgtgccc aggtcagctg tataaaataa atactgcatt gttgtttc                1308


<210>  814
<211>  389
<212>  PRT
<213>  Homosapiens

<400>  814

Met Pro Leu Glu Asn Leu Glu Glu Glu Gly Leu Pro Lys Asn Pro Asp 
1               5                   10                  15      


Leu Arg Ile Ala Gln Leu Arg Phe Leu Leu Ser Leu Pro Glu His Arg 
            20                  25                  30          


Gly Asp Ala Ala Val Arg Asp Glu Leu Met Ala Ala Val Arg Asp Asn 
        35                  40                  45              


Asn Met Ala Pro Tyr Tyr Glu Ala Leu Cys Lys Ser Leu Asp Trp Gln 
    50                  55                  60                  


Ile Asp Val Asp Leu Leu Asn Lys Met Lys Lys Ala Asn Glu Asp Glu 
65                  70                  75                  80  


Leu Lys Arg Leu Asp Glu Glu Leu Glu Asp Ala Glu Lys Asn Leu Gly 
                85                  90                  95      


Glu Ser Glu Ile Arg Asp Ala Met Met Ala Lys Ala Glu Tyr Leu Cys 
            100                 105                 110         


Arg Ile Gly Asp Lys Glu Gly Ala Leu Thr Ala Phe Arg Lys Thr Tyr 
        115                 120                 125             


Asp Lys Thr Val Ala Leu Gly His Arg Leu Asp Ile Val Phe Tyr Leu 
    130                 135                 140                 


Leu Arg Ile Gly Leu Phe Tyr Met Asp Asn Asp Leu Ile Thr Arg Asn 
145                 150                 155                 160 


Thr Glu Lys Ala Lys Ser Leu Ile Glu Glu Gly Gly Asp Trp Asp Arg 
                165                 170                 175     


Arg Asn Arg Leu Lys Val Tyr Gln Gly Leu Tyr Cys Val Ala Ile Arg 
            180                 185                 190         


Asp Phe Lys Gln Ala Ala Glu Leu Phe Leu Asp Thr Val Ser Thr Phe 
        195                 200                 205             


Thr Ser Tyr Glu Leu Met Asp Tyr Lys Thr Phe Val Thr Tyr Thr Val 
    210                 215                 220                 


Tyr Val Ser Met Ile Ala Leu Glu Arg Pro Asp Leu Arg Glu Lys Val 
225                 230                 235                 240 


Ile Lys Gly Ala Glu Ile Leu Glu Val Leu His Ser Leu Pro Ala Val 
                245                 250                 255     


Arg Gln Tyr Leu Phe Ser Leu Tyr Glu Cys Arg Tyr Ser Val Phe Phe 
            260                 265                 270         


Gln Ser Leu Ala Val Val Glu Gln Glu Met Lys Lys Asp Trp Leu Phe 
        275                 280                 285             


Ala Pro His Tyr Arg Tyr Tyr Val Arg Glu Met Arg Ile His Ala Tyr 
    290                 295                 300                 


Ser Gln Leu Leu Glu Ser Tyr Arg Ser Leu Thr Leu Gly Tyr Met Ala 
305                 310                 315                 320 


Glu Ala Phe Gly Val Gly Val Glu Phe Ile Asp Gln Glu Leu Ser Arg 
                325                 330                 335     


Phe Ile Ala Ala Gly Arg Leu His Cys Lys Ile Asp Lys Val Asn Glu 
            340                 345                 350         


Ile Val Glu Thr Asn Arg Pro Asp Ser Lys Asn Trp Gln Tyr Gln Glu 
        355                 360                 365             


Thr Ile Lys Lys Gly Asp Leu Leu Leu Asn Arg Val Gln Lys Leu Ser 
    370                 375                 380                 


Arg Val Ile Asn Met 
385                 


<210>  815
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  815
ggacttctca ggcaccacca gcagcgccac cgagagttat tattattttt tgaccaagca     60

gcacatttcc tggttcagtg gcttgagctc tgtgagcagc tgactagtca ccccgggtct    120

ggctcaggat cagctggtga cgctgggctg gagtctatga cttcttcctt cagattgtca    180

tgaagaaggg gagttaagag gaaactgggg gtcctccgga aggcgatctg agcactcagg    240

ctgatctaga ggaagagtag aagtcatact ttttttctct tgcttggtga attccccagc    300

agagtctgga tccagcagtg ctgttttccc tgagggaatg tggagcagct cggcttgagt    360

ctgttgccag cttcaggaag ggttcagact gaaaaggggg tttgaggaga agatgctttg    420

gctgcctgag gtcctgcttg cgttcttaga agtcagatcc agggagaaag tgaactggga    480

caattgacaa gctccaaggg tctggcagaa gcttcctccg agactgggca tttcatcctc    540

cctggaggaa gatctgcctg cactgcaagt gtccccagga ggagcacatg gtgacagtga    600

tgccgctgga gatggagaag accatcagca aactcatgtt tgactttcag aggaactcga    660

cctcagatga tgactcaggc tgtgctttgg aagagtatgc ctgggtcccg ccgggtctga    720

agcctgaaca ggtacaccag tactatagct gtctcccaga agagaaagtc ccttatgtca    780

acagtcctgg agagaaactg cgaatcaagc agctactaca ccagctgccg ccacatgaca    840

atgaggttcg atattgcaac tccctggatg aggaagagaa gagggagctg aagcttttca    900

gcagccagag gaaacgcgaa aacttgggcc gcgggaatgt caggcctttc ccagtcacca    960

tgacaggagc tatttgtgaa cagtgcggag gccagatcaa tggtggagac atcgctgtgt   1020

ttgcgtcacg cgctggccac ggcgtttgct ggcacccgcc gtgcttcgta tgcactgtct   1080

gcaatgagct cctggtggat ctgatctact tttaccaaga tgggaagata tactgtggca   1140

ggcaccatgc tgagtgcctg aagccgcgct gtgctgcctg cgatgagatc atctttgcag   1200

atgaatgcac agaagctgag gggcgacact ggcacatgaa acacttttgc tgcttcgagt   1260

gtgagacagt gctgggcggc cagcgctaca tcatgaagga gggaagaccc tactgttgcc   1320

actgcttcga gtccttgtat gcagaatatt gtgacacctg tgcccaacat ataggtatcg   1380

accaaggtca aatgacctat gacggccaac actggcatgc cactgagacc tgtttctgct   1440

gtgctcactg caagaaatcc ctcctggggc ggccattcct cccgaagcag ggccagatat   1500

tctgctcacg ggcctgcagt gctggggaag accccaatgg ttctgactcc tctgattccg   1560

ccttccagaa cgccagggcc aaggagtccc ggcgcagtgc caaaattggc aagaacaagg   1620

gcaagacgga ggagcccatg ctgaaccagc acagccagct gcaagtgagt tctaaccggc   1680

tgtcagccga cgtagacccc ctgtcactgc agatggacat gctcagcctg tccagccaga   1740

cacccagcct caaccgggac cccatctgga ggagccggga agagccctac cattatggga   1800

acaagatgga gcagaaccag acccagagcc ctctgcagct cctcagccag tgcaacatca   1860

gaacttccta cagtccagga gggcaagggg ctggggccca gcccgaaatg tggggcaagc   1920

acttcagcaa ccccaaaagg agctcgtcac tggccatgac aggacatgct ggcagcttca   1980

tcaaggaatg ccgagaagac tattacccgg ggaggctgag atctcaggag agctacagtg   2040

atatgtctag tcagagtttc agtgagaccc gaggcagcat ccaagtcccc aaatatgagg   2100

aggaagagga agaggaaggg ggcttgtcca ctcagcagtg tcggacccgt catcccatca   2160

gttccctgaa atacacagag gacatgacgc ccacagagca gacccctcgg ggctccatgg   2220

aatccctggc cctgtctaat gcaacaggcc tctctgctga tggtggtgcc aagcgccagg   2280

agcacctatc ccgattttcc atgcctgacc tcagcaaaga ctctggaatg aatgtgtctg   2340

agaagctgag caacatgggc actcttaact cgtccatgca gttccggagc gcagagtcag   2400

ttcgcagcct gctctctgcc cagcagtacc aggagatgga gggaaacctc caccagctca   2460

gcaaccccat tggctacaga gacctgcagt cccacggaag gatgcatcag agctttgatt   2520

ttgatggagg gatggcgggc agcaagctgc cagggcagga gggcgtgagg atccagccca   2580

tgagtgaacg cacccggaga agagctactt cacgcgacga caaccgccgt ttccgacctc   2640

acaggtccag gcgttcccga cgctctcgct ccgacaacgc cctccacctg gccagcgaac   2700

gcgaggccat ctcccggtta aaagataggc cccctctgag agccagggag gactatgacc   2760

aatttatgcg ccagcggagc ttccaggaga gcatggggca tgggtcccgg agggacctgt   2820

acggccagtg ccctaggact gtgtcggacc tggctttgca gaatgccttt ggggaccgct   2880

ggggacccta cttcgccgag tatgattggt gttccacctg ctcctcctct tcagagtctg   2940

acaacgaggg ctatttccta ggagaaccca tcccccagcc agcgcgcctg cgatacgtca   3000

caagcgatga gctgctgcac aaatacagct cctacggcct ccccaaatct tccacattag   3060

gtggcagagg acagttgcac agcaggaaaa gacagaagag caaaaactgt atcatttctt   3120

aatatgattg ggatcaggga atgggagaag atgggagcta agaatgtaaa gtcagaaact   3180

tgcactgttt taaatgttaa agcgcttttg ggggtggctt atgggggaga aaagggaaaa   3240

tgctgtcagt agatggaggc aaggttacag gttgactcaa taggtagtca cagttcttgg   3300

catgttgaat attatttgca catttcactt tggaaacaca gtagactcta tcgaggccag   3360

gcttggtcac ttccttccca tcagttctgt gttgagttgc catctctcaa gatggtaaat   3420

tgtttcctgc tcgcttttat cctctctggt tctcttactt ttaggaccct tttttcagta   3480

agtaatttgt ttattagcca ggacccaaga ctaagttatt tacatgtcca ttgtaaatgc   3540

aatgtaaatg agagttctga taaaatattt ttgtattttg taatatcaaa ggaatttcta   3600

tatcgtagga ctcagtgggg acttgcatgc acatccacca ttgtctctga gtagtattga   3660

aatgtggccc ggtaccacct tttttttttt tttttttttt ctatacaaat ttgttacatg   3720

tcagtgagac ctttttcaaa ggaacatatt caatttggct ttttgtggct gaaaaaacat   3780

aactgttaga cccaaagcat tttatgctcc gttccatctt aaggagccat ccttaagtct   3840

gctcccaccc tcagtagaat ttattttcta caaagtggta gtaatttttt tttaaattgc   3900

aaatgtaatt tttgccaatt agagaaacca accggtgtca gtaaaattct gtgagaaatg   3960

ccatccctgc tgggaatgtt gaagttactt aatgttgatc tatcccttgg ggaaagtaaa   4020

agtgactgtg agtggtgcca ttgtgtgatg tcagcatgac gttgttttga atgtggcatt   4080

atgttctggt gctcatgttt cctggattgt attatctgct ttcctttacc aaggcagaca   4140

gaactgctgc cttagcctga caaccggttg tcctcaaagc aaatgaactt aagcatttgg   4200

gattgaggga cagaaggatt ctgagggggc tctgcgaggg acggtgtgtg acatgtcatg   4260

cctggagaag gaacaaggct atttgaaaac agaaggcagg tcaagggtag aagttaaagg   4320

agaatctgaa ggcaggtcag ggaaaagaag aactggaaat gaaacagagg acaggtgaca   4380

accacctcga agagctcgca gagattgtag aaagagtcca gtgtaaccag cttagtaacc   4440

agagtatctg gattacccag gaaggttgag ctgctgagat ttcagtggtg caatgtcttt   4500

aaaaaaacag gctttgttgg gagggtattt ccattttgaa ctttgaggac tgttggtcag   4560

aaaatgggct caaaagtgag tttgcttaat gaagacattt aacggttgtg ctgtttatag   4620

taaaataaaa ctccctacct tgcttcagtt aaaaatgaag cacttggttt cttccatcct   4680

cctcctcccc ttaatggatt gtggcagttg aaataatcca tcggaggacc cacctgtagt   4740

gagatgtact gtcgatgtag tgcccggtgt atctcagtgg ccatctgcca tggtgaggtg   4800

agcgtgatct cttttcagta tagtagttaa cattttctag tattttttat ggagagaatg   4860

tcaaaagtgg catttcagac cccgtcccag atgggtctga ggaaaggaag gctgtaaagg   4920

acatggtaat ggcactccat tcgggatgta ttaaaataat ttgcttttca ggtattaata   4980

tgacatttgt cattgtcact gattttttta aaaaagcaat gcacatgttg gttgtggctg   5040

ttttccgcat gctatcttca tatctaaatg cttcattaat tatccgagcc tccggagaat   5100

taactctatt acgtttgtat agtaagtttg taaactgctt ggcaaactga ttaagaaata   5160

atttgcaata ccgtgttact aaagtggcag gtttctggta gaaattgtgc gagtccaatt   5220

tggagtttta agttccttga ttgatgaaac taaaaaggca attttggaaa aagagagggg   5280

gaaaagtaga tcacttatct tagcaaacgg ttgaaaatat gtctgtcctc tgtggcccca   5340

aatccagtga aagaaattct cccagtaaaa gttgcttcct aactctgttt ttctcagaat   5400

acctcttacc tttctcaaag aaagcttcaa ccaccatcat cagaaagaag gtggcctaaa   5460

aactgacaca tggccagtgc ccggaggggt ctggaggcat aagtctagat gcccagagag   5520

catccaggca ctgaactgct cagagcttga gatgaaatga catacaagct tcagggtaaa   5580

actgtctact agcaagatta cctccctcaa ttctaccatt gcagatttct tctgacccca   5640

aatgcaacct tacagagaat gctgaatgag gaaggccaat tccttacaat gatggcagaa   5700

cccccaagcg aatgccctat tgaggagaag gacatcactg tatttggaat tctgcctgct   5760

agtgatagct cacacatcac atcccagaat cccactccca atgcattatt tcctgaggca   5820

agaacttaag gtcctcacct aattcctcca tcacaaccat taactcttat tggacaagct   5880

cctcctgtga gtggggcctg tactcacttc ctcttagttc ataattccat cttcaagaga   5940

ctgatttcca gaatagtaat ctttttccag cgttctctct tctccaatgc cctggttgtt   6000

atttttccca cctctcctaa tattgatctt cttgtctttt ggttagaact gcaacttcgg   6060

agttgagttc atttcctatt gctgctcaat tcagtagcaa catagctggc ttgttcccag   6120

acccaggaag tataagtcat tgacagtttc ctgagtggct ctgccaatcc ataccaccct   6180

tggtactgtg aaaaggcttc ttggcagcca ggtggcattg aggatggtat tcagggcgct   6240

ttccttctgt catatagttg tgggatctct accaagtgtg aaggtgaatg aggtaaggga   6300

gatcagaacc atgcttcctg gtttttcata catccaagga agaagtcctg gtgtgggttg   6360

tttgacacct tctttccact ttcacctttt attttttatt ccttcctttc tacccccaac   6420

cagtcgagca aatgagcaat tttgtgtttc taatacagga tctggaagta gtgctttcta   6480

atcctcattt cctgtaggat gttcctgcac tataacaaga ttatgttttc ttccttctgc   6540

agcagctttc tgcttcttgg gtactactag ctattgttca attcaggtga ggcctgtgat   6600

gacatatatg tagcatgtgc tctgcgctcc ctgcaagctg agcagataca accaatgcat   6660

cactgtatac tcttgctgag aatgtggatg cagcctcaca gatctttgca acactccaac   6720

cagccaggac cagttgatca gaactgatct tattggtctg ataaccaatc ttatttgtga   6780

actgattcat atctgtcttt ccactcttgg ttttcttgcc gtagaacaaa aacagtttag   6840

gaagcataat tacgaacatt taggaaccaa tatgtataag taattcggag actccaattc   6900

acctgcccct cccccatccc aggttgtgga ggctcgagga agctgacttc ttaggctaaa   6960

ggacaaaaaa atctctttac ctccttggcc attttcatgt tctctgccaa ttactatagg   7020

cagtcttcat tttgcagagg tgaggtaaga cttcatctta ttcttcatgt aatcccacct   7080

tctaacaaaa aataaataaa tatttaaatt ccaaggagaa gtgttctttg tgtatttcta   7140

gcagaaaaca gatgcttaag cctaagaagg aagatccgtc catgacaaag gaaagtggaa   7200

aactgaacca gttatctgaa tacttcatgc caggacagtt gctattagca actgttttgc   7260

accttcaggg ctttaaaatg ggctctgcag acagcatttg catatgcaag actcagtagc   7320

caagcctcca ctgccaattg ttgaaggcag tttcagatcg ccaccttttg aggtacattt   7380

ctttaagcac aagagaagta gaaatggcct ttgccttgtc tccagtggtt tgtccctctg   7440

gtgcctcagc agataccaga gcttattctt atgaccattt ggaagtagtc ctcaaagtaa   7500

agatcaagaa aaaattggat tctttttcca ttttctcata atagtagcct agtcaacaca   7560

agactcccat aaaatatgac tcactattgg gagccatact attttataag cttacttcct   7620

gctgacaaaa ctagctttcc tcaaggaaat ataaaggagg ggaaagtcac atagtgttag   7680

gaaaacattc ctgtgttttg aatacgatga atccgtagga tagagaaaaa tctgcttgtt   7740

ctattctgag agttctctga gatatccctt cactctgctt ggcatttggc cattgatatt   7800

caacaggtca ctgaccaagc ttttctaaat ttttcagaga gagttactta ccaataaggt   7860

ctgttcttaa acctacctag ttgattttca tatctttcca taaagtgtca tgattctatc   7920

atagaccctg acttaacatt gtaaggacta tgagtcctcc attttttaat taattatttt   7980

ttagcaaatt aggacttcgg caggttttcc tctcctaaac tcattctttc ctccacagga   8040

ttgctttgtc catctcctct ttcatttcaa gtgcataaac aaaacctcaa agggcctggg   8100

aaggtgaggc aggccagagt ctgtgttctg tgttgagtgt caagctattt gttaagaagg   8160

tctgcaacag gcctttggtg tgggctctgc ca                                 8192


<210>  816
<211>  844
<212>  PRT
<213>  Homosapiens

<400>  816

Met Val Thr Val Met Pro Leu Glu Met Glu Lys Thr Ile Ser Lys Leu 
1               5                   10                  15      


Met Phe Asp Phe Gln Arg Asn Ser Thr Ser Asp Asp Asp Ser Gly Cys 
            20                  25                  30          


Ala Leu Glu Glu Tyr Ala Trp Val Pro Pro Gly Leu Lys Pro Glu Gln 
        35                  40                  45              


Val His Gln Tyr Tyr Ser Cys Leu Pro Glu Glu Lys Val Pro Tyr Val 
    50                  55                  60                  


Asn Ser Pro Gly Glu Lys Leu Arg Ile Lys Gln Leu Leu His Gln Leu 
65                  70                  75                  80  


Pro Pro His Asp Asn Glu Val Arg Tyr Cys Asn Ser Leu Asp Glu Glu 
                85                  90                  95      


Glu Lys Arg Glu Leu Lys Leu Phe Ser Ser Gln Arg Lys Arg Glu Asn 
            100                 105                 110         


Leu Gly Arg Gly Asn Val Arg Pro Phe Pro Val Thr Met Thr Gly Ala 
        115                 120                 125             


Ile Cys Glu Gln Cys Gly Gly Gln Ile Asn Gly Gly Asp Ile Ala Val 
    130                 135                 140                 


Phe Ala Ser Arg Ala Gly His Gly Val Cys Trp His Pro Pro Cys Phe 
145                 150                 155                 160 


Val Cys Thr Val Cys Asn Glu Leu Leu Val Asp Leu Ile Tyr Phe Tyr 
                165                 170                 175     


Gln Asp Gly Lys Ile Tyr Cys Gly Arg His His Ala Glu Cys Leu Lys 
            180                 185                 190         


Pro Arg Cys Ala Ala Cys Asp Glu Ile Ile Phe Ala Asp Glu Cys Thr 
        195                 200                 205             


Glu Ala Glu Gly Arg His Trp His Met Lys His Phe Cys Cys Phe Glu 
    210                 215                 220                 


Cys Glu Thr Val Leu Gly Gly Gln Arg Tyr Ile Met Lys Glu Gly Arg 
225                 230                 235                 240 


Pro Tyr Cys Cys His Cys Phe Glu Ser Leu Tyr Ala Glu Tyr Cys Asp 
                245                 250                 255     


Thr Cys Ala Gln His Ile Gly Ile Asp Gln Gly Gln Met Thr Tyr Asp 
            260                 265                 270         


Gly Gln His Trp His Ala Thr Glu Thr Cys Phe Cys Cys Ala His Cys 
        275                 280                 285             


Lys Lys Ser Leu Leu Gly Arg Pro Phe Leu Pro Lys Gln Gly Gln Ile 
    290                 295                 300                 


Phe Cys Ser Arg Ala Cys Ser Ala Gly Glu Asp Pro Asn Gly Ser Asp 
305                 310                 315                 320 


Ser Ser Asp Ser Ala Phe Gln Asn Ala Arg Ala Lys Glu Ser Arg Arg 
                325                 330                 335     


Ser Ala Lys Ile Gly Lys Asn Lys Gly Lys Thr Glu Glu Pro Met Leu 
            340                 345                 350         


Asn Gln His Ser Gln Leu Gln Val Ser Ser Asn Arg Leu Ser Ala Asp 
        355                 360                 365             


Val Asp Pro Leu Ser Leu Gln Met Asp Met Leu Ser Leu Ser Ser Gln 
    370                 375                 380                 


Thr Pro Ser Leu Asn Arg Asp Pro Ile Trp Arg Ser Arg Glu Glu Pro 
385                 390                 395                 400 


Tyr His Tyr Gly Asn Lys Met Glu Gln Asn Gln Thr Gln Ser Pro Leu 
                405                 410                 415     


Gln Leu Leu Ser Gln Cys Asn Ile Arg Thr Ser Tyr Ser Pro Gly Gly 
            420                 425                 430         


Gln Gly Ala Gly Ala Gln Pro Glu Met Trp Gly Lys His Phe Ser Asn 
        435                 440                 445             


Pro Lys Arg Ser Ser Ser Leu Ala Met Thr Gly His Ala Gly Ser Phe 
    450                 455                 460                 


Ile Lys Glu Cys Arg Glu Asp Tyr Tyr Pro Gly Arg Leu Arg Ser Gln 
465                 470                 475                 480 


Glu Ser Tyr Ser Asp Met Ser Ser Gln Ser Phe Ser Glu Thr Arg Gly 
                485                 490                 495     


Ser Ile Gln Val Pro Lys Tyr Glu Glu Glu Glu Glu Glu Glu Gly Gly 
            500                 505                 510         


Leu Ser Thr Gln Gln Cys Arg Thr Arg His Pro Ile Ser Ser Leu Lys 
        515                 520                 525             


Tyr Thr Glu Asp Met Thr Pro Thr Glu Gln Thr Pro Arg Gly Ser Met 
    530                 535                 540                 


Glu Ser Leu Ala Leu Ser Asn Ala Thr Gly Leu Ser Ala Asp Gly Gly 
545                 550                 555                 560 


Ala Lys Arg Gln Glu His Leu Ser Arg Phe Ser Met Pro Asp Leu Ser 
                565                 570                 575     


Lys Asp Ser Gly Met Asn Val Ser Glu Lys Leu Ser Asn Met Gly Thr 
            580                 585                 590         


Leu Asn Ser Ser Met Gln Phe Arg Ser Ala Glu Ser Val Arg Ser Leu 
        595                 600                 605             


Leu Ser Ala Gln Gln Tyr Gln Glu Met Glu Gly Asn Leu His Gln Leu 
    610                 615                 620                 


Ser Asn Pro Ile Gly Tyr Arg Asp Leu Gln Ser His Gly Arg Met His 
625                 630                 635                 640 


Gln Ser Phe Asp Phe Asp Gly Gly Met Ala Gly Ser Lys Leu Pro Gly 
                645                 650                 655     


Gln Glu Gly Val Arg Ile Gln Pro Met Ser Glu Arg Thr Arg Arg Arg 
            660                 665                 670         


Ala Thr Ser Arg Asp Asp Asn Arg Arg Phe Arg Pro His Arg Ser Arg 
        675                 680                 685             


Arg Ser Arg Arg Ser Arg Ser Asp Asn Ala Leu His Leu Ala Ser Glu 
    690                 695                 700                 


Arg Glu Ala Ile Ser Arg Leu Lys Asp Arg Pro Pro Leu Arg Ala Arg 
705                 710                 715                 720 


Glu Asp Tyr Asp Gln Phe Met Arg Gln Arg Ser Phe Gln Glu Ser Met 
                725                 730                 735     


Gly His Gly Ser Arg Arg Asp Leu Tyr Gly Gln Cys Pro Arg Thr Val 
            740                 745                 750         


Ser Asp Leu Ala Leu Gln Asn Ala Phe Gly Asp Arg Trp Gly Pro Tyr 
        755                 760                 765             


Phe Ala Glu Tyr Asp Trp Cys Ser Thr Cys Ser Ser Ser Ser Glu Ser 
    770                 775                 780                 


Asp Asn Glu Gly Tyr Phe Leu Gly Glu Pro Ile Pro Gln Pro Ala Arg 
785                 790                 795                 800 


Leu Arg Tyr Val Thr Ser Asp Glu Leu Leu His Lys Tyr Ser Ser Tyr 
                805                 810                 815     


Gly Leu Pro Lys Ser Ser Thr Leu Gly Gly Arg Gly Gln Leu His Ser 
            820                 825                 830         


Arg Lys Arg Gln Lys Ser Lys Asn Cys Ile Ile Ser 
        835                 840                 


<210>  817
<211>  2339
<212>  DNA
<213>  Homosapiens

<400>  817
ggcgtccccc gtagcagcgc aggccgggaa gcttctgcga gccctagcgc tgcggccccg     60

cttcctggcg gccgggtccc aggcagttta attaacctcc agaagatggc tgaacctgca    120

ggaataccag agcaagaaac tgatgtctga caacggagtg agagttcaaa gattctttgt    180

agcagacact gcaaatgaag ctctcgaggc tgctaagaga ctaaatgcaa aagaaattgt    240

tttaaaagcc cagatcttag ctggaggaag aggaaaaggt gtcttcaata gtggtttgaa    300

aggaggtgtt catttaacaa aagaccctaa tgttgtggga cagctggcta aacagatgat    360

tgggtacaat ctagcgacaa aacaaactcc aaaagaaggt gtgaaagtta acaaggtgat    420

ggttgctgaa gccttggata tttccagaga aacctacctg gcaattctga tggaccggtc    480

ctgcaatggc cccgtgctgg tgggcagccc ccaggggggc gtcgacattg aagaggtggc    540

tgcttcaaac ccggagctca tttttaagga gcaaattgac atttttgaag gaataaagga    600

cagccaagct cagcggatgg ccgaaaatct aggcttcgtt gggcctttga aaagccaggc    660

tgcagatcaa attacgaagc tgtataatct cttcctgaaa attgatgcta ctcaggtgga    720

agtgaatccc tttggtgaaa ctccagaagg acaagttgtc tgttttgatg ccaagataaa    780

ctttgatgac aacgcagaat tccgacaaaa agacatattt gctatggacg acaaatcaga    840

gaatgagccc attgaaaatg aagctgccaa atatgatcta aaatacatag gactagatgg    900

gaacattgcc tgctttgtga atggtgctgg gctcgccatg gctacttgtg atatcatttt    960

ccttaatggt gggaagccag ccaacttctt ggatcttgga ggtggtgtaa aggaagctca   1020

agtatatcaa gcattcaaat tgctcacagc tgatcctaag gttgaagcca tccttgtcaa   1080

tatatttggt ggtatcgtca actgtgccat cattgccaat gggatcacca aagcctgccg   1140

ggagctagaa ctcaaggtgc ccctggtggt ccggcttgaa ggaaccaacg tccaagaggc   1200

ccagaagata ctcaacaaca gcggactccc cattacttca gccattgacc tggaggatgc   1260

agccaagaag gctgtggcca gtgtggccaa gaagtgatgt ctttgtcctg atccaatgga   1320

gaaagaaagc catttttcca taaaaaggga tggttcatca ttgtgaaaga aatggttatc   1380

tcattgggga agaaaagggg agggggaagg caagaatcac tgaaaaatct taaatctgtg   1440

ttttctggaa taagatatct agacagccta aatctgattt tagtctttat aaaaataata   1500

tcttgtgttc tcatactttt ctgtcactgt aagcctgccc agtaggcagt gttttgcaga   1560

ctttggggag tggtctatgt ggccaaatat tgtgtgtata gacagaattt gaaatcaagt   1620

cctgcttcat ttacaagaat tttggtgggc atcgaatcct acataatgaa aaagaaaaac   1680

agaccattta aaaactcaga caagattata tttaatatat taattactaa aaaggcacaa   1740

gattacactg aacatattag ctactaaaaa ggcactgcta agacattcaa gcaaatagct   1800

attacacact actgcagatt ttacaggttt ctaattctaa catatgtttg aaaaatccgt   1860

gagtattcca aaatatattt aataatggaa tatctgcatt aatataccat ccatgtgttt   1920

ttaccatttg ccttaatatt gaatatactg tttacctcac actaaaaaga aaaccagaag   1980

ccttatttgt gattttggga gtggaagctt ccatttttgt gtcaaaaatg aatcctgatt   2040

cttatggaaa tctctgttat taagatattt caagatgaga caacactgaa gatcaaattg   2100

tgtttagtat cactatcttc tctcctcgtt tctctcttac tcctcatcct cccagaatct   2160

accagtttat ggtagaaaga tgggaacctt atttgaatgt gttttttttt ttccatgatg   2220

tccaattttg ttgtgggaaa ggatttggat aaaatttttg tttaaatttt ggtagatttt   2280

tatctataca aatttaaata aaattatgtt ttgtaagctg aaaaaaaaaa aaaaaaaaa    2339


<210>  818
<211>  384
<212>  PRT
<213>  Homosapiens

<400>  818

Met Ser Asp Asn Gly Val Arg Val Gln Arg Phe Phe Val Ala Asp Thr 
1               5                   10                  15      


Ala Asn Glu Ala Leu Glu Ala Ala Lys Arg Leu Asn Ala Lys Glu Ile 
            20                  25                  30          


Val Leu Lys Ala Gln Ile Leu Ala Gly Gly Arg Gly Lys Gly Val Phe 
        35                  40                  45              


Asn Ser Gly Leu Lys Gly Gly Val His Leu Thr Lys Asp Pro Asn Val 
    50                  55                  60                  


Val Gly Gln Leu Ala Lys Gln Met Ile Gly Tyr Asn Leu Ala Thr Lys 
65                  70                  75                  80  


Gln Thr Pro Lys Glu Gly Val Lys Val Asn Lys Val Met Val Ala Glu 
                85                  90                  95      


Ala Leu Asp Ile Ser Arg Glu Thr Tyr Leu Ala Ile Leu Met Asp Arg 
            100                 105                 110         


Ser Cys Asn Gly Pro Val Leu Val Gly Ser Pro Gln Gly Gly Val Asp 
        115                 120                 125             


Ile Glu Glu Val Ala Ala Ser Asn Pro Glu Leu Ile Phe Lys Glu Gln 
    130                 135                 140                 


Ile Asp Ile Phe Glu Gly Ile Lys Asp Ser Gln Ala Gln Arg Met Ala 
145                 150                 155                 160 


Glu Asn Leu Gly Phe Val Gly Pro Leu Lys Ser Gln Ala Ala Asp Gln 
                165                 170                 175     


Ile Thr Lys Leu Tyr Asn Leu Phe Leu Lys Ile Asp Ala Thr Gln Val 
            180                 185                 190         


Glu Val Asn Pro Phe Gly Glu Thr Pro Glu Gly Gln Val Val Cys Phe 
        195                 200                 205             


Asp Ala Lys Ile Asn Phe Asp Asp Asn Ala Glu Phe Arg Gln Lys Asp 
    210                 215                 220                 


Ile Phe Ala Met Asp Asp Lys Ser Glu Asn Glu Pro Ile Glu Asn Glu 
225                 230                 235                 240 


Ala Ala Lys Tyr Asp Leu Lys Tyr Ile Gly Leu Asp Gly Asn Ile Ala 
                245                 250                 255     


Cys Phe Val Asn Gly Ala Gly Leu Ala Met Ala Thr Cys Asp Ile Ile 
            260                 265                 270         


Phe Leu Asn Gly Gly Lys Pro Ala Asn Phe Leu Asp Leu Gly Gly Gly 
        275                 280                 285             


Val Lys Glu Ala Gln Val Tyr Gln Ala Phe Lys Leu Leu Thr Ala Asp 
    290                 295                 300                 


Pro Lys Val Glu Ala Ile Leu Val Asn Ile Phe Gly Gly Ile Val Asn 
305                 310                 315                 320 


Cys Ala Ile Ile Ala Asn Gly Ile Thr Lys Ala Cys Arg Glu Leu Glu 
                325                 330                 335     


Leu Lys Val Pro Leu Val Val Arg Leu Glu Gly Thr Asn Val Gln Glu 
            340                 345                 350         


Ala Gln Lys Ile Leu Asn Asn Ser Gly Leu Pro Ile Thr Ser Ala Ile 
        355                 360                 365             


Asp Leu Glu Asp Ala Ala Lys Lys Ala Val Ala Ser Val Ala Lys Lys 
    370                 375                 380                 


<210>  819
<211>  937
<212>  DNA
<213>  Homosapiens

<400>  819
ggggggtggg cgccagcgcc ccggcgaacg gcaaagaggg agccgctccc gctcgggggg     60

ccgctggagt gcccagcggg aacccgaaag tttgtaagag gaagagagcg cgcggcgagc    120

gagcgagcgg gccgggggca gcggcagcgg cgccggggac catggtgctg ccggcgcctc    180

ctccgcgggc gtgaaggcgg cgctcctact ccctccccgg actccgcggt gtcccagaag    240

cttttgttga caattccagt ttccgaacaa aacatttcgg caatggtgag ggcttcgatc    300

ccttctctga tttgctgtca gccatgaacg gatggatgtg atgcctgcta gccaaaaggc    360

ttccctctgt gtgttgcagt cctgtggcat tatgcatgcc ccctcccagt gaccccaggc    420

tttttatggc tgtgagacac gttaaaattt caggggtaag acgtgacctt ttgaggtgac    480

tataactgaa gattgcttta cagaagccaa aaaaggtttt tgagtcatga tgcaagaatc    540

tgggactgag acaaaaagta acggttcagc catccagaat gggtcgggcg gcagcaacca    600

cttactagag tgcggcggtc ttcgggaggg gcggtccaac ggagagacgc cggccgtgga    660

catcggggca gctgacctcg cccacgccca gcagcagcag caacagtggc atctcataaa    720

ccatcagccc tctaggagtc ccagcagttg gcttaagaga ctaatttcaa gcccttggga    780

gttggaagtc ctgcaggtcc ccttgtgggg agcagttgct gagacgaaga tgagtggacc    840

tgtgtgtcag cctaaccctt ccccattttg aataaaatta ttctttggag aaaaaaaaaa    900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                             937


<210>  820
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  820

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Trp His Leu Ile 
    50                  55                  60                  


Asn His Gln Pro Ser Arg Ser Pro Ser Ser Trp Leu Lys Arg Leu Ile 
65                  70                  75                  80  


Ser Ser Pro Trp Glu Leu Glu Val Leu Gln Val Pro Leu Trp Gly Ala 
                85                  90                  95      


Val Ala Glu Thr Lys Met Ser Gly Pro Val Cys Gln Pro Asn Pro Ser 
            100                 105                 110         


Pro Phe 
        


<210>  821
<211>  6222
<212>  DNA
<213>  Homosapiens

<400>  821
ggggggtggg cgccagcgcc ccggcgaacg gcaaagaggg agccgctccc gctcgggggg     60

ccgctggagt gcccagcggg aacccgaaag tttgtaagag gaagagagcg cgcggcgagc    120

gagcgagcgg gccgggggca gcggcagcgg cgccggggac catggtgctg ccggcgcctc    180

ctccgcgggc gtgaaggcgg cgctcctact ccctccccgg actccgcggt gtcccagaag    240

cttttgttga caattccagt ttccgaacaa aacatttcgg caatggtgag ggcttcgatc    300

ccttctctga tttgctgtca gccatgaacg gatggatgtg atgcctgcta gccaaaaggc    360

ttccctctgt gtgttgcagt cctgtggcat tatgcatgcc ccctcccagt gaccccaggc    420

tttttatggc tgtgagacac gttaaaattt caggggtaag acgtgacctt ttgaggtgac    480

tataactgaa gattgcttta cagaagccaa aaaaggtttt tgagtcatga tgcaagaatc    540

tgggactgag acaaaaagta acggttcagc catccagaat gggtcgggcg gcagcaacca    600

cttactagag tgcggcggtc ttcgggaggg gcggtccaac ggagagacgc cggccgtgga    660

catcggggca gctgacctcg cccacgccca gcagcagcag caacaggcac ttcaggtggc    720

aagacagctc cttcttcagc agcaacagca gcagcaagtt agtggattaa aatctcccaa    780

gaggaatgac aaacaaccag ctcttcaggt tcccgtgtca gtggctatga tgacacctca    840

agttatcact ccccagcaaa tgcagcagat cctccagcaa caagtgctga gccctcagca    900

gctccaggtt ctcctccagc agcagcaggc cctcatgctt caacagcagc agcttcaaga    960

gttttataaa aaacaacagg aacagttgca gcttcaactt ttacaacaac aacatgctgg   1020

aaaacagcct aaagagcaac agcaggtggc tacccagcag ttggcttttc agcagcagct   1080

tttacagatg cagcagttac agcagcagca cctcctgtct ttgcagcgcc aaggccttct   1140

gacaattcag cccgggcagc ctgcccttcc ccttcaacct cttgctcaag gcatgattcc   1200

aacagaactg cagcagctct ggaaagaagt gacaagtgct catactgcag aagaaaccac   1260

aggcaacaat cacagcagtt tggatctgac cacgacatgt gtctcctcct ctgcaccttc   1320

caagacctcc ttaataatga acccacatgc ctctaccaat ggacagctct cagtccacac   1380

tcccaaaagg gaaagtttgt cccatgagga gcacccccat agccatcctc tctatggaca   1440

tggtgtatgc aagtggccag gctgtgaagc agtgtgcgaa gatttccaat catttctaaa   1500

acatctcaac agtgagcatg cgctggacga tagaagtaca gcccaatgta gagtacaaat   1560

gcaggttgta cagcagttag agctacagct tgcaaaagac aaagaacgcc tgcaagccat   1620

gatgacccac ctgcatgtga agtctacaga acccaaagcc gcccctcagc ccttgaatct   1680

ggtatcaagt gtcactctct ccaagtccgc atcggaggct tctccacaga gcttacctca   1740

tactccaacg accccaaccg cccccctgac tcccgtcacc caaggcccct ctgtcatcac   1800

aaccaccagc atgcacacgg tgggacccat ccgcaggcgg tactcagaca aatacaacgt   1860

gcccatttcg tcagcagata ttgcgcagaa ccaagaattt tataagaacg cagaagttag   1920

accaccattt acatatgcat ctttaattag gcaggccatt ctcgaatctc cagaaaagca   1980

gctaacacta aatgagatct ataactggtt cacacgaatg tttgcttact tccgacgcaa   2040

cgcggccacg tggaagaatg cagtgcgtca taatcttagt cttcacaagt gttttgtgcg   2100

agtagaaaac gttaaagggg cagtatggac agtggatgaa gtagaattcc aaaaacgaag   2160

gccacaaaag atcagtggta acccttccct tattaaaaac atgcagagca gccacgccta   2220

ctgcacacct ctcaatgcag ctttacaggc ttcaatggct gagaatagta tacctctata   2280

cactaccgct tccatgggaa atcccactct gggcaactta gccagcgcaa tacgggaaga   2340

gctgaacggg gcaatggagc ataccaacag caacgagagt gacagcagtc caggcagatc   2400

tcctatgcaa gccgtgcatc ctgtacacgt caaagaagag cccctcgatc cagaggaagc   2460

tgaagggccc ctgtccttag tgacaacagc caaccacagt ccagattttg accatgacag   2520

agattacgaa gatgaaccag taaacgagga catggagtga ctatcggggc gggccaaccc   2580

cgagaatgaa gattggaaaa aggaaaaaaa aaaaaacacg tcaaaagtta gcagtgaaat   2640

tgttctccat ttgttgtaca gtctggagga ttttcactac gttttgacaa ctctgaaatg   2700

tgttaactct tagtgccatc aagaacccca tttgggagta tttttgattt ttctactttt   2760

tgttgaaaaa aggaatttgt actctgtgca ttggatggac ttgtttggta cttgggattt   2820

tcctctctta accgtcaaca tcagtgttgt aaatttgcta aactgattca cttttagcag   2880

cagactttga actgcagtcc tgccaacgtt ggacactgag gacgcccgac agagcttgtg   2940

cacctaagct gcagaccaag cctttgccca gaatttaagg attccaatgg acgacctatt   3000

tgcacagtac tgcatgttga ttatcactgc ctttactcct tttttttttt tttttttttt   3060

tttttttttg cttccagttg ggatggggaa ggcctttgtg tgtgtattgg ggggaggggt   3120

taaaaaataa ttatcccaaa ctttttaatg tattgctttt tttttttttt tttttccttc   3180

tactatacca ttttaagttc tgacctcagg cctccatttg ggccgatggc ctcttggagg   3240

cttaaagttt tctgtacctt gtgatgaatg ttaataggtg tttttattat acaaagctga   3300

atgtcatttc tcgtttgtag ctttctgtca ctcattccat cttccttcag acatcaccac   3360

gtttctctaa agtcagaaaa cattccgttt tggtcttttt caaaaaggtc ccaaatgctg   3420

cactctacac atgaaggccc tctcacacag acgtgacgtc ctgccagaaa gagaatgaat   3480

gacagaaaaa aaaaagagag acaaactcta ggaacaatgc cgattcattc cacgcagcag   3540

tattgggggt ggttcggggg aggggtgttt cggattttct ttttttcttt tcttttcttt   3600

tttttttttt gcagcaacca ttaataaatg ccaccacatt ctaccagcac aaggaaacat   3660

aggcagcact gaaaaaaaaa aaaaagctca tattaattag actgacaata tggccttgga   3720

aggctctccc ttgtggaacc aagttgccat gggccttggg tgctctgcga taacgggtgt   3780

gggttggttt tgtttgcaaa atggccaaaa aaaaaaaccg gcttccccga gcagctgccc   3840

tgaaagtagg ggtggcggcg gcggcgctga gtttatacat tagttcagac ctacttggtg   3900

gcattaaact gtttgaatgc aaattcgatt tcagattgaa cttgttaagg gagttaacga   3960

gggctgagtt cagcaaatgc taaagtgtta atttcaaata tgcaaatttg gtactgcagt   4020

ttgttatgca atattatatc accaacccag tatcacaaaa actcatagaa gatatcatgt   4080

aggccctggg ctttgggggg gtcccaaaca tggtatgcag aaatgtgatg gttacaggtc   4140

agtacaacct cagtccttag aacccctcca cacttcagct ctgcacccac tttcctgtca   4200

tttatttata taggactgta gtttttttta gttcgagagc ctttcgaagc ttaatttata   4260

ttctttcttt gtaccttttt tctaaaatta ccaaagatat tacacaaagg taaattatgt   4320

tctctgtttt atgctttatc tgatgaagcc aaatatcctc ttattgttga tcaaaggagg   4380

caaaagaatt tagaggcaaa tgacaagcga taggctattg caacctgaga aagagaactg   4440

ctccttcatc gtaaatttag aagaccaagt agataatgga accaaagttg ttactttttt   4500

ctagtagtta tttttccttt ttctttttgt gtacctctac agagaccaaa actcattctc   4560

ttaaagagat tttatggggc tactgcagat aaaaatagga cacaatatta aaggagctac   4620

agaaggaagg gagtcccatc tcaaaaaaaa aatgaatgta tgccactgca attagagtat   4680

ccaataaagg agacagttta gagtcaggac agaaaagctt ccataattga actagattac   4740

ataatagtat ttctagaaaa agagatattt ttagattgta tgccactttt gtttaagaac   4800

tgtgctgtga tcactgtatt aattttggtt tatcttggca tatatccttc agtttgtttt   4860

tatttttaat ttttcctttt tttccgatta ggctttggtc agcatttttc atttaaagaa   4920

aagtaacact cccatccact cataagcttg gtacaaaaac ttctctggca gttacttttg   4980

aagcttcact ctgctttctg tataaagggc agtctgtggt cacgcaagac tttaaaaaaa   5040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaacttttc caggcagctt catgatgtgc   5100

aggcagtagc cagacagggt catgggaagg gggccctgtg cttctaaact gagtggttgc   5160

tggttagttt ggtattcaaa agaggataaa aatctggtag attagttcat tctcagcatg   5220

tgtagctaga catgagtaaa gataacagca tgagaaactg ttagtacgca tacctcagtt   5280

caaaccttta gggaatgatt aaaatttaaa aaaaaaacat ttcactcagt tgcacttagt   5340

cgtatgtctt gcatgcttag tctaaagact gtagcaaaaa aaaaaaaaaa agaaaaatta   5400

gattttacat atctttgcag gtatcacagc cttgcagaag aaccaactga aaaaaaaatt   5460

ctcaggcttt acagcaagca aacttcacta tgatttttac aattctgatt ctgtatcccc   5520

tgggggttat cccagttgct tctttaggat ggggtttatt acgttgtaca tatatcccga   5580

tgtgtctgtg tgaatctttg tcttttttgg gggagggcag agggcggttc tttttttaga   5640

tattgttcct aaaaaggaat aaatgcatac acctgtttgt caaaacacct ttgctttttg   5700

tgcaactgct ttatattaac gatactaaaa aaaaatagct ttggaaaaaa aactactgta   5760

tgtaacggaa ttgcagaata tgctgcacat gtattttatt tagttatcct tgctttaaga   5820

atattggatg acatttcctg acatgtggga gggagaaact ccctaacttt ttttttctgc   5880

ttttaaactg taacatagtt gaagatttct tttttctgtt ctcattgatt ggagcatttt   5940

gtacaggttt tgtgtgtgtg tgtgtgtgtg tgtgcgcgcg tgcgtgtgtg ttaatctgtt   6000

ttttgataca ttcctatccc ttgtgtttat cctaccactg ccttcctggc tatcttaaac   6060

aagttcatac atttgaaaag aaaaaaaaat gttgtttaaa aaatgttttc tcctgctgca   6120

gtaaatattt tgcatgatga aattccaggg tcacactttt ccaagtttat cagtgaagta   6180

gtgattaaca atggggagtg tcaaaactat tgaacttttg ta                      6222


<210>  822
<211>  677
<212>  PRT
<213>  Homosapiens

<400>  822

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg 
    530                 535                 540                 


Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln 
545                 550                 555                 560 


Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser 
                565                 570                 575     


Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn 
            580                 585                 590         


Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly 
        595                 600                 605             


Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg 
    610                 615                 620                 


Ser Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu 
625                 630                 635                 640 


Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn 
                645                 650                 655     


His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val 
            660                 665                 670         


Asn Glu Asp Met Glu 
        675         


<210>  823
<211>  2861
<212>  DNA
<213>  Homosapiens

<400>  823
gtccctcaca ccgagagttc ctgcgcgtgg ggagttggag agtttgcgtg gcgggaacgc     60

ggcggcagtg agagcgagcg gcgccggccc ttgcgtccgg tgcggcgatg ctgaccccgg    120

cgttcgacct cagccaggat ccggacttcc tgactatcgc catccgcgtg ccctacgccc    180

gggtctccga gttcgacgtc tacttcgagg ggtctgactt caagttctac gccaagccat    240

actttctcag attaaccctt cctggaagaa ttgtagaaaa tggaagtgag caagggtcct    300

atgatgcaga taaaggaatt tttaccattc gcctgcccaa agaaacccct ggccagcatt    360

ttgaggggct gaacatgtta actgctcttc tggcaccaag aaaatccagg acagcaaaac    420

cacttgtgga agaaataggt gcttctgaga ttcctgagga agtagttgac gatgaagagt    480

ttgattggga aattgagcag acaccctgtg aagaggtatc agaaagtgct ttgaatccgc    540

agtgccacta tggatttgga aacttacgat caggagtgtt gcaacggtta caggatgaac    600

tgagtgatgt tattgatatt aaggatccag atttcacccc tgcagctgaa cgaagacaga    660

agcgcctggc cgctgagctg gccaagtttg atcctgatca ttatctagct gacttttttg    720

aagatgaggc gattgaacag attttgaagt ataatccttg gtggactgac aaatattcaa    780

aaatgatggc ctttttggaa aagagtcagg aacaagaaaa tcatgctaca ttagtgtctt    840

tttctgaaga agagaagtat cagctacgaa aatttgtcaa taaatcttat ctgctggaca    900

agagagcctg tcgtcaagtg tgctacagtt tgattgatat ccttctggca tattgctatg    960

aaacccgtgt cactgaagga gagaagaatg ttgaatctgc atggaatatc aggaaactga   1020

gtccaacact atgctggttt gagacttgga ctaacgttca tgatatcatg gtgtcttttg   1080

gaagaagggt gttgtgttac ccactctatc gccatttcaa gctggtgatg aaggcctaca   1140

gggacactat aaagatattg caactgggta aaagtgcagt tttaaagtgt ctcctggata   1200

ttcacaaaat ttttcaggaa aatgacccag cgtacatact gaatgatctc tacatctcag   1260

actactgtgt gtggattcag aaagtcaaat ccaaaaagtt ggcagctctt gcagaagcct   1320

taaaggaagt ctcccttaca aaggcccagc tggggttaga actggaagaa ctagaagcag   1380

cagcactgct tgtccaggag gaagaaactg cattaaaagc agcccattca gtttctgggc   1440

agcagacact ttgctccagc tctgaggcaa gtgattcgga ggactcagac agcagcgtgt   1500

catctggaaa cgaagactca ggctcagatt cagaacaaga tgaactcaaa gatagtccat   1560

ctgagacagt cagttctttg caaggtccct ttcttgaaga aagcagtgcc tttcttattg   1620

ttgatggtgg agtacgcaga aacacagcca tccaggagtc tgatgccagt cagggaaagc   1680

cacttgcctc ttcctggcct cttggagtgt ctgggcctct gatagaggag cttggggaac   1740

aactgaagac tacagttcag gtttctgaac ccaagggcac cactgctgta aaccgcagca   1800

atattcagga gagagacggc tgtcagacac caaataattg actcttaggt ggttttattc   1860

attgttgaga aatatggtag attgggtttc atttaccgaa tgagaattct tcattttcac   1920

tttgtaattt ttcttagtat atagtcagcc cactgtattt gtgtgttcca catctgtgga   1980

ttcaaccaac tgcagatcaa aaatattgaa gaaaaaatcg catctgtacc aaacatgtac   2040

agactttttt cttgttatta ttctctaaat aatacagtat gacaactatt tccacagcat   2100

ttacattgta ttgggtaata taagtaatct agtgatgatt taaactgtgc aggaggatgt   2160

gggtaggtta tatgcaaata ctgcaccatt ttttatcagg ggcttgagca tctgaggatt   2220

ttagtatcct caggagtcct ggaaccaacc ccccacagat acggggacaa ctttatgaca   2280

ttgtttttca accaatgaat gtttatacct tttgttttcc ttgccgcgac tgtgaagata   2340

aagttcaaaa gtatttttac caaagtgtag ctaatatttc aagctgaaaa taatagttct   2400

actgcccgtg tctccagaat gtagagccca tcaatatttt tattttagga ggtgtacttg   2460

acacccaata aactgcacgt atcaaaagtg tacaatgtgt tggcgtatgt ataccctgcg   2520

taaaactatc accacaactg aagtgaggaa cggacccatc attcccaagt gcccttgtgc   2580

cctgttatta gtttgcatgt cctagaattc tatgtaaatt gaatcataca atatgtatcc   2640

cttttttggt caggcatatt ttactcagta tagttatttt gagattcatc catgtggtag   2700

catgtgtcac gagtttttgt ttttatgttt ttcattgctg agtactgctt cattgaatag   2760

atttgttcat tgacctatcg atggacacct gggttgtttc cagtttgggg ctgttataaa   2820

taaagctgtt atgaacattt gtgtacaaaa aaaaaaaaaa a                       2861


<210>  824
<211>  577
<212>  PRT
<213>  Homosapiens

<400>  824

Met Leu Thr Pro Ala Phe Asp Leu Ser Gln Asp Pro Asp Phe Leu Thr 
1               5                   10                  15      


Ile Ala Ile Arg Val Pro Tyr Ala Arg Val Ser Glu Phe Asp Val Tyr 
            20                  25                  30          


Phe Glu Gly Ser Asp Phe Lys Phe Tyr Ala Lys Pro Tyr Phe Leu Arg 
        35                  40                  45              


Leu Thr Leu Pro Gly Arg Ile Val Glu Asn Gly Ser Glu Gln Gly Ser 
    50                  55                  60                  


Tyr Asp Ala Asp Lys Gly Ile Phe Thr Ile Arg Leu Pro Lys Glu Thr 
65                  70                  75                  80  


Pro Gly Gln His Phe Glu Gly Leu Asn Met Leu Thr Ala Leu Leu Ala 
                85                  90                  95      


Pro Arg Lys Ser Arg Thr Ala Lys Pro Leu Val Glu Glu Ile Gly Ala 
            100                 105                 110         


Ser Glu Ile Pro Glu Glu Val Val Asp Asp Glu Glu Phe Asp Trp Glu 
        115                 120                 125             


Ile Glu Gln Thr Pro Cys Glu Glu Val Ser Glu Ser Ala Leu Asn Pro 
    130                 135                 140                 


Gln Cys His Tyr Gly Phe Gly Asn Leu Arg Ser Gly Val Leu Gln Arg 
145                 150                 155                 160 


Leu Gln Asp Glu Leu Ser Asp Val Ile Asp Ile Lys Asp Pro Asp Phe 
                165                 170                 175     


Thr Pro Ala Ala Glu Arg Arg Gln Lys Arg Leu Ala Ala Glu Leu Ala 
            180                 185                 190         


Lys Phe Asp Pro Asp His Tyr Leu Ala Asp Phe Phe Glu Asp Glu Ala 
        195                 200                 205             


Ile Glu Gln Ile Leu Lys Tyr Asn Pro Trp Trp Thr Asp Lys Tyr Ser 
    210                 215                 220                 


Lys Met Met Ala Phe Leu Glu Lys Ser Gln Glu Gln Glu Asn His Ala 
225                 230                 235                 240 


Thr Leu Val Ser Phe Ser Glu Glu Glu Lys Tyr Gln Leu Arg Lys Phe 
                245                 250                 255     


Val Asn Lys Ser Tyr Leu Leu Asp Lys Arg Ala Cys Arg Gln Val Cys 
            260                 265                 270         


Tyr Ser Leu Ile Asp Ile Leu Leu Ala Tyr Cys Tyr Glu Thr Arg Val 
        275                 280                 285             


Thr Glu Gly Glu Lys Asn Val Glu Ser Ala Trp Asn Ile Arg Lys Leu 
    290                 295                 300                 


Ser Pro Thr Leu Cys Trp Phe Glu Thr Trp Thr Asn Val His Asp Ile 
305                 310                 315                 320 


Met Val Ser Phe Gly Arg Arg Val Leu Cys Tyr Pro Leu Tyr Arg His 
                325                 330                 335     


Phe Lys Leu Val Met Lys Ala Tyr Arg Asp Thr Ile Lys Ile Leu Gln 
            340                 345                 350         


Leu Gly Lys Ser Ala Val Leu Lys Cys Leu Leu Asp Ile His Lys Ile 
        355                 360                 365             


Phe Gln Glu Asn Asp Pro Ala Tyr Ile Leu Asn Asp Leu Tyr Ile Ser 
    370                 375                 380                 


Asp Tyr Cys Val Trp Ile Gln Lys Val Lys Ser Lys Lys Leu Ala Ala 
385                 390                 395                 400 


Leu Ala Glu Ala Leu Lys Glu Val Ser Leu Thr Lys Ala Gln Leu Gly 
                405                 410                 415     


Leu Glu Leu Glu Glu Leu Glu Ala Ala Ala Leu Leu Val Gln Glu Glu 
            420                 425                 430         


Glu Thr Ala Leu Lys Ala Ala His Ser Val Ser Gly Gln Gln Thr Leu 
        435                 440                 445             


Cys Ser Ser Ser Glu Ala Ser Asp Ser Glu Asp Ser Asp Ser Ser Val 
    450                 455                 460                 


Ser Ser Gly Asn Glu Asp Ser Gly Ser Asp Ser Glu Gln Asp Glu Leu 
465                 470                 475                 480 


Lys Asp Ser Pro Ser Glu Thr Val Ser Ser Leu Gln Gly Pro Phe Leu 
                485                 490                 495     


Glu Glu Ser Ser Ala Phe Leu Ile Val Asp Gly Gly Val Arg Arg Asn 
            500                 505                 510         


Thr Ala Ile Gln Glu Ser Asp Ala Ser Gln Gly Lys Pro Leu Ala Ser 
        515                 520                 525             


Ser Trp Pro Leu Gly Val Ser Gly Pro Leu Ile Glu Glu Leu Gly Glu 
    530                 535                 540                 


Gln Leu Lys Thr Thr Val Gln Val Ser Glu Pro Lys Gly Thr Thr Ala 
545                 550                 555                 560 


Val Asn Arg Ser Asn Ile Gln Glu Arg Asp Gly Cys Gln Thr Pro Asn 
                565                 570                 575     


Asn 
    


<210>  825
<211>  6629
<212>  DNA
<213>  Homosapiens

<400>  825
atgaaatgga aacatgttcc ttttttggtc atgatatcac tcctcagctt atccccaaat     60

cacctgtttc tggcccagct tattccagac cctgaagatg tagagagggg gaacgaccac    120

gggacgccaa tccccacctc tgataacgat gacaattcgc tgggctatac aggctcccgt    180

cttcgtcagg aagattttcc acctcgcatt gttgaacacc cttcagacct gattgtctca    240

aaaggagaac ctgcaacttt gaactgcaaa gctgaaggcc gccccacacc cactattgaa    300

tggtacaaag ggggagagag agtggagaca gacaaagatg accctcgctc acaccgaatg    360

ttgctgccga gtggatcttt atttttctta cgtatagtac atggacggaa aagtagacct    420

gatgaaggag tctatgtctg tgtagcaagg aattaccttg gagaggctgt gagccacaat    480

gcatcgctgg aagtagccat acttcgggat gacttcagac aaaacccttc ggatgtcatg    540

gttgcagtag gagagcctgc agtaatggaa tgccaacctc cacgaggcca tcctgagccc    600

accatttcat ggaagaaaga tggctctcca ctggatgata aagatgaaag aataactata    660

cgaggaggaa agctcatgat cacttacacc cgtaaaagtg acgctggcaa atatgtttgt    720

gttggtacca atatggttgg ggaacgtgag agtgaagtag ccgagctgac tgtcttagag    780

agaccatcat ttgtgaagag acccagtaac ttggcagtaa ctgtggatga cagtgcagaa    840

tttaaatgtg aggcccgagg tgaccctgta cctacagtac gatggaggaa agatgatgga    900

gagctgccca aatccagata tgaaatccga gatgatcata ccttgaaaat taggaaggtg    960

acagctggtg acatgggttc atacacttgt gttgcagaaa atatggtggg caaagctgaa   1020

gcatctgcta ctctgactgt tcaagaacct ccacattttg ttgtgaaacc ccgtgaccag   1080

gttgttgctt tgggacggac tgtaactttt cagtgtgaag caaccggaaa tcctcaacca   1140

gctattttct ggaggagaga agggagtcag aatctacttt tctcatatca accaccacag   1200

tcatccagcc gattttcagt ctcccagact ggcgacctca caattactaa tgtccagcga   1260

tctgatgttg gttattacat ctgccagact ttaaatgttg ctggaagcat catcacaaag   1320

gcatatttgg aagttacaga tgtgattgca gatcggcctc ccccagttat tcgacaaggt   1380

cctgtgaatc agactgtagc cgtggatggc actttcgtcc tcagctgtgt ggccacaggc   1440

agtccagtgc ccaccattct gtggagaaag gatggagtcc tcgtttcaac ccaagactct   1500

cgaatcaaac agttggagaa tggagtactg cagatccgat atgctaagct gggtgatact   1560

ggtcggtaca cctgcattgc atcaaccccc agtggtgaag caacatggag tgcttacatt   1620

gaagttcaag aatttggagt tccagttcag cctccaagac ctactgaccc aaatttaatc   1680

cctagtgccc catcaaaacc tgaagtgaca gatgtcagca gaaatacagt cacattatcg   1740

tggcaaccaa atttgaattc aggagcaact ccaacatctt atattataga agccttcagc   1800

catgcatctg gtagcagctg gcagaccgta gcagagaatg tgaaaacaga aacatctgcc   1860

attaaaggac tcaaacctaa tgcaatttac cttttccttg tgagggcagc taatgcatat   1920

ggaattagtg atccaagcca aatatcagat ccagtgaaaa cacaagatgt cctaccaaca   1980

agtcaggggg tggaccacaa gcaggtccag agagagctgg gaaatgctgt tctgcacctc   2040

cacaacccca ccgtcctttc ttcctcttcc atcgaagtgc actggacagt agatcaacag   2100

tctcagtata tacaaggata taaaattctc tatcggccat ctggagccaa ccacggagaa   2160

tcagactggt tagtttttga agtgaggacg ccagccaaaa acagtgtggt aatccctgat   2220

ctcagaaagg gagtcaacta tgaaattaag gctcgccctt tttttaatga atttcaagga   2280

gcagatagtg aaatcaagtt tgccaaaacc ctggaagaag cacccagtgc cccaccccaa   2340

ggtgtaactg tatccaagaa tgatggaaac ggaactgcaa ttctagttag ttggcagcca   2400

cctccagaag acactcaaaa tggaatggtc caagagtata aggtttggtg tctgggcaat   2460

gaaactcgat accacatcaa caaaacagtg gatggttcca ccttttccgt ggtcattccc   2520

tttcttgttc ctggaatccg atacagtgtg gaagtggcag ccagcactgg ggctgggtct   2580

ggggtaaaga gtgagcctca gttcatccag ctggatgccc atggaaaccc tgtgtcacct   2640

gaggaccaag tcagcctcgc tcagcagatt tcagatgtgg tgaagcagcc ggccttcata   2700

gcaggtattg gagcagcctg ttggatcatc ctcatggtct tcagcatctg gctttatcga   2760

caccgcaaga agagaaacgg acttactagt acctacgcgg gtatcagaaa agtcccgtct   2820

tttaccttca caccaacagt aacttaccag agaggaggcg aagctgtcag cagtggaggg   2880

aggcctggac ttctcaacat cagtgaacct gccgcgcagc catggctggc agacacgtgg   2940

cctaatactg gcaacaacca caatgactgc tccatcagct gctgcacggc aggcaatgga   3000

aacagcgaca gcaacctcac tacctacagt cgcccagctg attgtatagc aaattataac   3060

aaccaactgg ataacaaaca aacaaatctg atgctccctg agtcaactgt ttatggtgat   3120

gtggacctta gtaacaaaat caatgagatg aaaaccttca atagcccaaa tctgaaggat   3180

gggcgttttg tcaatccatc agggcagcct actccttacg ccaccactca gctcatccag   3240

tcaaacctca gcaacaacat gaacaatggc agcggggact ctggcgagaa gcactggaaa   3300

ccactgggac agcagaaaca agaagtggca ccagttcagt acaacatcgt ggagcaaaac   3360

aagctgaaca aagattatcg agcaaatgac acagttcctc caactatccc atacaaccaa   3420

tcatacgacc agaacacagg aggatcctac aacagctcag accggggcag tagtacatct   3480

gggagtcagg ggcacaagaa aggggcaaga acacccaagg taccaaaaca gggtggcatg   3540

aactgggcag acctgcttcc tcctccccca gcacatcctc ctccacacag caatagcgaa   3600

gagtacaaca tttctgtaga tgaaagctat gaccaagaaa tgccatgtcc cgtgccacca   3660

gcaaggatgt atttgcaaca agatgaatta gaagaggagg aagatgaacg aggccccact   3720

ccccctgttc ggggagcagc ttcttctcca gctgccgtgt cctatagcca tcagtccact   3780

gccactctga ctccctcccc acaggaagaa ctccagccca tgttacagga ttgtccagag   3840

gagactggcc acatgcagca ccagcccgac aggagacggc agcctgtgag tcctcctcca   3900

ccaccacggc cgatctcccc tccacatacc tatggctaca tttcaggacc cctggtctca   3960

gatatggata cggatgcgcc agaagaggaa gaagacgaag ccgacatgga ggtagccaag   4020

atgcaaacca gaaggctttt gttacgtggg cttgagcaga cacctgcctc cagtgttggg   4080

gacctggaga gctctgtcac ggggtccatg atcaacggct ggggctcagc ctcagaggag   4140

gacaacattt ccagcggacg ctccagtgtt agttcttcgg acggctcctt tttcactgat   4200

gctgactttg cccaggcagt cgcagcagcg gcagagtatg ctggtctgaa agtagcacga   4260

cggcaaatgc aggatgctgc tggccgtcga cattttcatg cgtctcagtg ccctaggccc   4320

acaagtcccg tgtctacaga cagcaacatg agtgccgccg taatgcagaa aaccagacca   4380

gccaagaaac tgaaacacca gccaggacat ctgcgcagag aaacctacac agatgatctt   4440

ccaccacctc ctgtgccgcc acctgctata aagtcaccta ctgcccaatc caagacacag   4500

ctggaagtac gacctgtagt ggtgccaaaa ctcccttcta tggatgcaag aacagacaga   4560

tcatcagaca gaaaaggaag cagttacaag gggagagaag tgttggatgg aagacaggtt   4620

gttgacatgc gaacaaatcc aggtgatccc agagaagcac aggaacagca aaatgacggg   4680

aaaggacgtg gaaacaaggc agcaaaacga gaccttccac cagcaaagac tcatctcatc   4740

caagaggata ttctacctta ttgtagacct acttttccaa catcaaataa tcccagagat   4800

cccagttcct caagctcaat gtcatcaaga ggatcaggaa gcagacaaag agaacaagca   4860

aatgtaggtc gaagaaatat tgcagaaatg caggtacttg gaggatatga aagaggagaa   4920

gataataatg aagaattaga ggaaactgaa agctgaagac aaccaagagg cttatgagat   4980

ctaatgtgaa aatcatcact caagatgcct cctgtcagat gacacatgac gccagataaa   5040

atgttcagtg caatcagagt gtacaaattg tcgtttttat tcctcttatt gggatatcat   5100

tttaaaaact ttattgggtt tttattgttg ttgtttgatc cctaacccta caaagagcct   5160

tcctattccc ctcgctgttg gagcaaacca ttatacctta cttccagcaa gcaaagtgct   5220

ttgacttctt gcttcagtca tcagccagca agagggaaca aaactgttct tttgcatttt   5280

gccgctgaga tatggcattg cactgcttat atgccaagct aatttatagc aagatattga   5340

tcaaatatag aaagttgata ttcaacctca caagggctct caaagtataa tctttctata   5400

gccaactgct aatgcaaatt aaaacatatt tcattttaac atgatttcaa aatcagtttt   5460

tcatactacc ctttgctgga agaaactaaa aatatagcaa atgcagaacc acaaacaatt   5520

cgaatggggt agaaacattg taaatattta ctctttgcaa accctggtgg tattttattt   5580

tggcttcatt tcaatcattg aagtatattc ttattggaaa tgtacttttg gataagtagg   5640

gctaagccag ttggatctct ggttgtctag tcattgtcat aagtaaacct agtaaaacct   5700

tgttctattt ttcaatcatc aaaaagtaat tataaatacg tattacaaac aagtggatgt   5760

ttttaatgac caattgagta agaacatccc tgtcttaact ggcctaaatt tcttctggta   5820

gtgtcagttc aactttcaga agtgccactt aaggaagttt gatttttgtt tttgtaatgc   5880

actgttttta atctctctct cttttttttt ttttttttgg ttttaaaagc acaatcacta   5940

aactttattt gtaaaccatt gtaactatta accttttttg tcttattgaa aaaaaaaatg   6000

ttgagaagcg tttttaacct gttttgttaa tgctctatgt ttgtatttgg aatatttgaa   6060

taatgacaga tggtgaagta acatgcatac tttattgtgg gccatgaacc aaatggttct   6120

tacttttcct ggacttaaag aaaaaaagag gtttaagttt gttgtggcca atgtcgaaac   6180

ctacaagatt tccttaaaat ctctaataga ggcattactt gctttcaatt gacaaatgat   6240

gccctctgac tagtagattt ctatgatcct tttttgtcat tttatgaata tcattgattt   6300

tataattggt gctatttgaa gaaaaaaatg tacatttatt catagataga taagtatcag   6360

gtctgacccc agtggaaaac aaagccaaac aaaactgaac cacaaaaaaa aaggctggtg   6420

ttcaccaaaa ccaaacttgt tcatttagat aatttgaaaa agttccatag aaaaggcgtg   6480

cagtactaag ggaacaatcc atgtgattaa tgttttcatt atgttcatgt aagaagcccc   6540

ttatttttag ccataatttt gcatactgaa aatccaataa tcagaaaagt aattttgtca   6600

cattatttat taaaaatgtt ctcaaatac                                     6629


<210>  826
<211>  1651
<212>  PRT
<213>  Homosapiens

<400>  826

Met Lys Trp Lys His Val Pro Phe Leu Val Met Ile Ser Leu Leu Ser 
1               5                   10                  15      


Leu Ser Pro Asn His Leu Phe Leu Ala Gln Leu Ile Pro Asp Pro Glu 
            20                  25                  30          


Asp Val Glu Arg Gly Asn Asp His Gly Thr Pro Ile Pro Thr Ser Asp 
        35                  40                  45              


Asn Asp Asp Asn Ser Leu Gly Tyr Thr Gly Ser Arg Leu Arg Gln Glu 
    50                  55                  60                  


Asp Phe Pro Pro Arg Ile Val Glu His Pro Ser Asp Leu Ile Val Ser 
65                  70                  75                  80  


Lys Gly Glu Pro Ala Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr 
                85                  90                  95      


Pro Thr Ile Glu Trp Tyr Lys Gly Gly Glu Arg Val Glu Thr Asp Lys 
            100                 105                 110         


Asp Asp Pro Arg Ser His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe 
        115                 120                 125             


Phe Leu Arg Ile Val His Gly Arg Lys Ser Arg Pro Asp Glu Gly Val 
    130                 135                 140                 


Tyr Val Cys Val Ala Arg Asn Tyr Leu Gly Glu Ala Val Ser His Asn 
145                 150                 155                 160 


Ala Ser Leu Glu Val Ala Ile Leu Arg Asp Asp Phe Arg Gln Asn Pro 
                165                 170                 175     


Ser Asp Val Met Val Ala Val Gly Glu Pro Ala Val Met Glu Cys Gln 
            180                 185                 190         


Pro Pro Arg Gly His Pro Glu Pro Thr Ile Ser Trp Lys Lys Asp Gly 
        195                 200                 205             


Ser Pro Leu Asp Asp Lys Asp Glu Arg Ile Thr Ile Arg Gly Gly Lys 
    210                 215                 220                 


Leu Met Ile Thr Tyr Thr Arg Lys Ser Asp Ala Gly Lys Tyr Val Cys 
225                 230                 235                 240 


Val Gly Thr Asn Met Val Gly Glu Arg Glu Ser Glu Val Ala Glu Leu 
                245                 250                 255     


Thr Val Leu Glu Arg Pro Ser Phe Val Lys Arg Pro Ser Asn Leu Ala 
            260                 265                 270         


Val Thr Val Asp Asp Ser Ala Glu Phe Lys Cys Glu Ala Arg Gly Asp 
        275                 280                 285             


Pro Val Pro Thr Val Arg Trp Arg Lys Asp Asp Gly Glu Leu Pro Lys 
    290                 295                 300                 


Ser Arg Tyr Glu Ile Arg Asp Asp His Thr Leu Lys Ile Arg Lys Val 
305                 310                 315                 320 


Thr Ala Gly Asp Met Gly Ser Tyr Thr Cys Val Ala Glu Asn Met Val 
                325                 330                 335     


Gly Lys Ala Glu Ala Ser Ala Thr Leu Thr Val Gln Glu Pro Pro His 
            340                 345                 350         


Phe Val Val Lys Pro Arg Asp Gln Val Val Ala Leu Gly Arg Thr Val 
        355                 360                 365             


Thr Phe Gln Cys Glu Ala Thr Gly Asn Pro Gln Pro Ala Ile Phe Trp 
    370                 375                 380                 


Arg Arg Glu Gly Ser Gln Asn Leu Leu Phe Ser Tyr Gln Pro Pro Gln 
385                 390                 395                 400 


Ser Ser Ser Arg Phe Ser Val Ser Gln Thr Gly Asp Leu Thr Ile Thr 
                405                 410                 415     


Asn Val Gln Arg Ser Asp Val Gly Tyr Tyr Ile Cys Gln Thr Leu Asn 
            420                 425                 430         


Val Ala Gly Ser Ile Ile Thr Lys Ala Tyr Leu Glu Val Thr Asp Val 
        435                 440                 445             


Ile Ala Asp Arg Pro Pro Pro Val Ile Arg Gln Gly Pro Val Asn Gln 
    450                 455                 460                 


Thr Val Ala Val Asp Gly Thr Phe Val Leu Ser Cys Val Ala Thr Gly 
465                 470                 475                 480 


Ser Pro Val Pro Thr Ile Leu Trp Arg Lys Asp Gly Val Leu Val Ser 
                485                 490                 495     


Thr Gln Asp Ser Arg Ile Lys Gln Leu Glu Asn Gly Val Leu Gln Ile 
            500                 505                 510         


Arg Tyr Ala Lys Leu Gly Asp Thr Gly Arg Tyr Thr Cys Ile Ala Ser 
        515                 520                 525             


Thr Pro Ser Gly Glu Ala Thr Trp Ser Ala Tyr Ile Glu Val Gln Glu 
    530                 535                 540                 


Phe Gly Val Pro Val Gln Pro Pro Arg Pro Thr Asp Pro Asn Leu Ile 
545                 550                 555                 560 


Pro Ser Ala Pro Ser Lys Pro Glu Val Thr Asp Val Ser Arg Asn Thr 
                565                 570                 575     


Val Thr Leu Ser Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro Thr 
            580                 585                 590         


Ser Tyr Ile Ile Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp Gln 
        595                 600                 605             


Thr Val Ala Glu Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly Leu 
    610                 615                 620                 


Lys Pro Asn Ala Ile Tyr Leu Phe Leu Val Arg Ala Ala Asn Ala Tyr 
625                 630                 635                 640 


Gly Ile Ser Asp Pro Ser Gln Ile Ser Asp Pro Val Lys Thr Gln Asp 
                645                 650                 655     


Val Leu Pro Thr Ser Gln Gly Val Asp His Lys Gln Val Gln Arg Glu 
            660                 665                 670         


Leu Gly Asn Ala Val Leu His Leu His Asn Pro Thr Val Leu Ser Ser 
        675                 680                 685             


Ser Ser Ile Glu Val His Trp Thr Val Asp Gln Gln Ser Gln Tyr Ile 
    690                 695                 700                 


Gln Gly Tyr Lys Ile Leu Tyr Arg Pro Ser Gly Ala Asn His Gly Glu 
705                 710                 715                 720 


Ser Asp Trp Leu Val Phe Glu Val Arg Thr Pro Ala Lys Asn Ser Val 
                725                 730                 735     


Val Ile Pro Asp Leu Arg Lys Gly Val Asn Tyr Glu Ile Lys Ala Arg 
            740                 745                 750         


Pro Phe Phe Asn Glu Phe Gln Gly Ala Asp Ser Glu Ile Lys Phe Ala 
        755                 760                 765             


Lys Thr Leu Glu Glu Ala Pro Ser Ala Pro Pro Gln Gly Val Thr Val 
    770                 775                 780                 


Ser Lys Asn Asp Gly Asn Gly Thr Ala Ile Leu Val Ser Trp Gln Pro 
785                 790                 795                 800 


Pro Pro Glu Asp Thr Gln Asn Gly Met Val Gln Glu Tyr Lys Val Trp 
                805                 810                 815     


Cys Leu Gly Asn Glu Thr Arg Tyr His Ile Asn Lys Thr Val Asp Gly 
            820                 825                 830         


Ser Thr Phe Ser Val Val Ile Pro Phe Leu Val Pro Gly Ile Arg Tyr 
        835                 840                 845             


Ser Val Glu Val Ala Ala Ser Thr Gly Ala Gly Ser Gly Val Lys Ser 
    850                 855                 860                 


Glu Pro Gln Phe Ile Gln Leu Asp Ala His Gly Asn Pro Val Ser Pro 
865                 870                 875                 880 


Glu Asp Gln Val Ser Leu Ala Gln Gln Ile Ser Asp Val Val Lys Gln 
                885                 890                 895     


Pro Ala Phe Ile Ala Gly Ile Gly Ala Ala Cys Trp Ile Ile Leu Met 
            900                 905                 910         


Val Phe Ser Ile Trp Leu Tyr Arg His Arg Lys Lys Arg Asn Gly Leu 
        915                 920                 925             


Thr Ser Thr Tyr Ala Gly Ile Arg Lys Val Pro Ser Phe Thr Phe Thr 
    930                 935                 940                 


Pro Thr Val Thr Tyr Gln Arg Gly Gly Glu Ala Val Ser Ser Gly Gly 
945                 950                 955                 960 


Arg Pro Gly Leu Leu Asn Ile Ser Glu Pro Ala Ala Gln Pro Trp Leu 
                965                 970                 975     


Ala Asp Thr Trp Pro Asn Thr Gly Asn Asn His Asn Asp Cys Ser Ile 
            980                 985                 990         


Ser Cys Cys Thr Ala Gly Asn Gly  Asn Ser Asp Ser Asn  Leu Thr Thr 
        995                 1000                 1005             


Tyr Ser  Arg Pro Ala Asp Cys  Ile Ala Asn Tyr Asn  Asn Gln Leu 
    1010                 1015                 1020             


Asp Asn  Lys Gln Thr Asn Leu  Met Leu Pro Glu Ser  Thr Val Tyr 
    1025                 1030                 1035             


Gly Asp  Val Asp Leu Ser Asn  Lys Ile Asn Glu Met  Lys Thr Phe 
    1040                 1045                 1050             


Asn Ser  Pro Asn Leu Lys Asp  Gly Arg Phe Val Asn  Pro Ser Gly 
    1055                 1060                 1065             


Gln Pro  Thr Pro Tyr Ala Thr  Thr Gln Leu Ile Gln  Ser Asn Leu 
    1070                 1075                 1080             


Ser Asn  Asn Met Asn Asn Gly  Ser Gly Asp Ser Gly  Glu Lys His 
    1085                 1090                 1095             


Trp Lys  Pro Leu Gly Gln Gln  Lys Gln Glu Val Ala  Pro Val Gln 
    1100                 1105                 1110             


Tyr Asn  Ile Val Glu Gln Asn  Lys Leu Asn Lys Asp  Tyr Arg Ala 
    1115                 1120                 1125             


Asn Asp  Thr Val Pro Pro Thr  Ile Pro Tyr Asn Gln  Ser Tyr Asp 
    1130                 1135                 1140             


Gln Asn  Thr Gly Gly Ser Tyr  Asn Ser Ser Asp Arg  Gly Ser Ser 
    1145                 1150                 1155             


Thr Ser  Gly Ser Gln Gly His  Lys Lys Gly Ala Arg  Thr Pro Lys 
    1160                 1165                 1170             


Val Pro  Lys Gln Gly Gly Met  Asn Trp Ala Asp Leu  Leu Pro Pro 
    1175                 1180                 1185             


Pro Pro  Ala His Pro Pro Pro  His Ser Asn Ser Glu  Glu Tyr Asn 
    1190                 1195                 1200             


Ile Ser  Val Asp Glu Ser Tyr  Asp Gln Glu Met Pro  Cys Pro Val 
    1205                 1210                 1215             


Pro Pro  Ala Arg Met Tyr Leu  Gln Gln Asp Glu Leu  Glu Glu Glu 
    1220                 1225                 1230             


Glu Asp  Glu Arg Gly Pro Thr  Pro Pro Val Arg Gly  Ala Ala Ser 
    1235                 1240                 1245             


Ser Pro  Ala Ala Val Ser Tyr  Ser His Gln Ser Thr  Ala Thr Leu 
    1250                 1255                 1260             


Thr Pro  Ser Pro Gln Glu Glu  Leu Gln Pro Met Leu  Gln Asp Cys 
    1265                 1270                 1275             


Pro Glu  Glu Thr Gly His Met  Gln His Gln Pro Asp  Arg Arg Arg 
    1280                 1285                 1290             


Gln Pro  Val Ser Pro Pro Pro  Pro Pro Arg Pro Ile  Ser Pro Pro 
    1295                 1300                 1305             


His Thr  Tyr Gly Tyr Ile Ser  Gly Pro Leu Val Ser  Asp Met Asp 
    1310                 1315                 1320             


Thr Asp  Ala Pro Glu Glu Glu  Glu Asp Glu Ala Asp  Met Glu Val 
    1325                 1330                 1335             


Ala Lys  Met Gln Thr Arg Arg  Leu Leu Leu Arg Gly  Leu Glu Gln 
    1340                 1345                 1350             


Thr Pro  Ala Ser Ser Val Gly  Asp Leu Glu Ser Ser  Val Thr Gly 
    1355                 1360                 1365             


Ser Met  Ile Asn Gly Trp Gly  Ser Ala Ser Glu Glu  Asp Asn Ile 
    1370                 1375                 1380             


Ser Ser  Gly Arg Ser Ser Val  Ser Ser Ser Asp Gly  Ser Phe Phe 
    1385                 1390                 1395             


Thr Asp  Ala Asp Phe Ala Gln  Ala Val Ala Ala Ala  Ala Glu Tyr 
    1400                 1405                 1410             


Ala Gly  Leu Lys Val Ala Arg  Arg Gln Met Gln Asp  Ala Ala Gly 
    1415                 1420                 1425             


Arg Arg  His Phe His Ala Ser  Gln Cys Pro Arg Pro  Thr Ser Pro 
    1430                 1435                 1440             


Val Ser  Thr Asp Ser Asn Met  Ser Ala Ala Val Met  Gln Lys Thr 
    1445                 1450                 1455             


Arg Pro  Ala Lys Lys Leu Lys  His Gln Pro Gly His  Leu Arg Arg 
    1460                 1465                 1470             


Glu Thr  Tyr Thr Asp Asp Leu  Pro Pro Pro Pro Val  Pro Pro Pro 
    1475                 1480                 1485             


Ala Ile  Lys Ser Pro Thr Ala  Gln Ser Lys Thr Gln  Leu Glu Val 
    1490                 1495                 1500             


Arg Pro  Val Val Val Pro Lys  Leu Pro Ser Met Asp  Ala Arg Thr 
    1505                 1510                 1515             


Asp Arg  Ser Ser Asp Arg Lys  Gly Ser Ser Tyr Lys  Gly Arg Glu 
    1520                 1525                 1530             


Val Leu  Asp Gly Arg Gln Val  Val Asp Met Arg Thr  Asn Pro Gly 
    1535                 1540                 1545             


Asp Pro  Arg Glu Ala Gln Glu  Gln Gln Asn Asp Gly  Lys Gly Arg 
    1550                 1555                 1560             


Gly Asn  Lys Ala Ala Lys Arg  Asp Leu Pro Pro Ala  Lys Thr His 
    1565                 1570                 1575             


Leu Ile  Gln Glu Asp Ile Leu  Pro Tyr Cys Arg Pro  Thr Phe Pro 
    1580                 1585                 1590             


Thr Ser  Asn Asn Pro Arg Asp  Pro Ser Ser Ser Ser  Ser Met Ser 
    1595                 1600                 1605             


Ser Arg  Gly Ser Gly Ser Arg  Gln Arg Glu Gln Ala  Asn Val Gly 
    1610                 1615                 1620             


Arg Arg  Asn Ile Ala Glu Met  Gln Val Leu Gly Gly  Tyr Glu Arg 
    1625                 1630                 1635             


Gly Glu  Asp Asn Asn Glu Glu  Leu Glu Glu Thr Glu  Ser 
    1640                 1645                 1650     


<210>  827
<211>  7475
<212>  DNA
<213>  Homosapiens

<400>  827
acttcagacg ccgctgatcc gggaggagct ggggtgagcc gcggcggccg tctctcccac     60

ccgcagcagc atcctctctg cccttctctg ccaccccggg gagagccggg agctgcctct    120

ttacagcttc cacgagccag gggtgcaggc agctgccccc aggaagtttg ggcttctgcg    180

tagtttaggg gtgcctgcga gcgccccaga gggcgagggg ccgagggcga tgttgggcgc    240

cgcgcggggc tgggggcgcc cagaagacgt gcgagtgtcc gcggtcctgc tgctgtctcc    300

agtaccctcc gcatccccca agtgatggga acaagggccc gcccaggcag ccgctgtcgc    360

cgcaccgccc cctcgctcgc tctctgcgcg cggagtcacc cagtcacact cccggcaccc    420

cgagcccttc ctccggagct gctgcttcta ctttggctgc tatcgccgcc gccgcgggtg    480

gcccgctgct gactgggctc gccgggagac ggagaagcac tttttggccc tccctcagca    540

gctctcacac cccaactttg ccgccgccgc cgcgcctgcc ctcgcagcgg cgctcggccg    600

cacattgtgg gggcgcacgc cgggaggctc cgcaagaccg tggaggcagg aaacggcact    660

actgcgcttc tgcctcggct ctttgttgtt cgctttggat ggttcttgaa agtgtctgag    720

cctcctcgga aatcctgggg ccggagaaga caaaccttgg aattcttcct ctgcaaaagt    780

ctctgagata ctgacaagcg tccggaaagg tcgacgagta attgccctga aaactcttgg    840

ctaattgacc cacgttgctt atattaagcc tttgtgtgtg gtgtgtggct tcatacattt    900

ggggacccta tttccactcc ctcctcttgg catgagactg tatacaggat ccacccgagg    960

acaatgattg cggagcccgc tcacttttac ctgtttggat taatatgtct ctgttcaggc   1020

tcccgtcttc gtcaggaaga ttttccacct cgcattgttg aacacccttc agacctgatt   1080

gtctcaaaag gagaacctgc aactttgaac tgcaaagctg aaggccgccc cacacccact   1140

attgaatggt acaaaggggg agagagagtg gagacagaca aagatgaccc tcgctcacac   1200

cgaatgttgc tgccgagtgg atctttattt ttcttacgta tagtacatgg acggaaaagt   1260

agacctgatg aaggagtcta tgtctgtgta gcaaggaatt accttggaga ggctgtgagc   1320

cacaatgcat cgctggaagt agccatactt cgggatgact tcagacaaaa cccttcggat   1380

gtcatggttg cagtaggaga gcctgcagta atggaatgcc aacctccacg aggccatcct   1440

gagcccacca tttcatggaa gaaagatggc tctccactgg atgataaaga tgaaagaata   1500

actatacgag gaggaaagct catgatcact tacacccgta aaagtgacgc tggcaaatat   1560

gtttgtgttg gtaccaatat ggttggggaa cgtgagagtg aagtagccga gctgactgtc   1620

ttagagagac catcatttgt gaagagaccc agtaacttgg cagtaactgt ggatgacagt   1680

gcagaattta aatgtgaggc ccgaggtgac cctgtaccta cagtacgatg gaggaaagat   1740

gatggagagc tgcccaaatc cagatatgaa atccgagatg atcatacctt gaaaattagg   1800

aaggtgacag ctggtgacat gggttcatac acttgtgttg cagaaaatat ggtgggcaaa   1860

gctgaagcat ctgctactct gactgttcaa gaacctccac attttgttgt gaaaccccgt   1920

gaccaggttg ttgctttggg acggactgta acttttcagt gtgaagcaac cggaaatcct   1980

caaccagcta ttttctggag gagagaaggg agtcagaatc tacttttctc atatcaacca   2040

ccacagtcat ccagccgatt ttcagtctcc cagactggcg acctcacaat tactaatgtc   2100

cagcgatctg atgttggtta ttacatctgc cagactttaa atgttgctgg aagcatcatc   2160

acaaaggcat atttggaagt tacagatgtg attgcagatc ggcctccccc agttattcga   2220

caaggtcctg tgaatcagac tgtagccgtg gatggcactt tcgtcctcag ctgtgtggcc   2280

acaggcagtc cagtgcccac cattctgtgg agaaaggatg gagtcctcgt ttcaacccaa   2340

gactctcgaa tcaaacagtt ggagaatgga gtactgcaga tccgatatgc taagctgggt   2400

gatactggtc ggtacacctg cattgcatca acccccagtg gtgaagcaac atggagtgct   2460

tacattgaag ttcaagaatt tggagttcca gttcagcctc caagacctac tgacccaaat   2520

ttaatcccta gtgccccatc aaaacctgaa gtgacagatg tcagcagaaa tacagtcaca   2580

ttatcgtggc aaccaaattt gaattcagga gcaactccaa catcttatat tatagaagcc   2640

ttcagccatg catctggtag cagctggcag accgtagcag agaatgtgaa aacagaaaca   2700

tctgccatta aaggactcaa acctaatgca atttaccttt tccttgtgag ggcagctaat   2760

gcatatggaa ttagtgatcc aagccaaata tcagatccag tgaaaacaca agatgtccta   2820

ccaacaagtc agggggtgga ccacaagcag gtccagagag agctgggaaa tgctgttctg   2880

cacctccaca accccaccgt cctttcttcc tcttccatcg aagtgcactg gacagtagat   2940

caacagtctc agtatataca aggatataaa attctctatc ggccatctgg agccaaccac   3000

ggagaatcag actggttagt ttttgaagtg aggacgccag ccaaaaacag tgtggtaatc   3060

cctgatctca gaaagggagt caactatgaa attaaggctc gccctttttt taatgaattt   3120

caaggagcag atagtgaaat caagtttgcc aaaaccctgg aagaagcacc cagtgcccca   3180

ccccaaggtg taactgtatc caagaatgat ggaaacggaa ctgcaattct agttagttgg   3240

cagccacctc cagaagacac tcaaaatgga atggtccaag agtataaggt ttggtgtctg   3300

ggcaatgaaa ctcgatacca catcaacaaa acagtggatg gttccacctt ttccgtggtc   3360

attccctttc ttgttcctgg aatccgatac agtgtggaag tggcagccag cactggggct   3420

gggtctgggg taaagagtga gcctcagttc atccagctgg atgcccatgg aaaccctgtg   3480

tcacctgagg accaagtcag cctcgctcag cagatttcag atgtggtgaa gcagccggcc   3540

ttcatagcag gtattggagc agcctgttgg atcatcctca tggtcttcag catctggctt   3600

tatcgacacc gcaagaagag aaacggactt actagtacct acgcgggtat cagaaaagtc   3660

ccgtctttta ccttcacacc aacagtaact taccagagag gaggcgaagc tgtcagcagt   3720

ggagggaggc ctggacttct caacatcagt gaacctgccg cgcagccatg gctggcagac   3780

acgtggccta atactggcaa caaccacaat gactgctcca tcagctgctg cacggcaggc   3840

aatggaaaca gcgacagcaa cctcactacc tacagtcgcc cagctgattg tatagcaaat   3900

tataacaacc aactggataa caaacaaaca aatctgatgc tccctgagtc aactgtttat   3960

ggtgatgtgg accttagtaa caaaatcaat gagatgaaaa ccttcaatag cccaaatctg   4020

aaggatgggc gttttgtcaa tccatcaggg cagcctactc cttacgccac cactcagctc   4080

atccagtcaa acctcagcaa caacatgaac aatggcagcg gggactctgg cgagaagcac   4140

tggaaaccac tgggacagca gaaacaagaa gtggcaccag ttcagtacaa catcgtggag   4200

caaaacaagc tgaacaaaga ttatcgagca aatgacacag ttcctccaac tatcccatac   4260

aaccaatcat acgaccagaa cacaggagga tcctacaaca gctcagaccg gggcagtagt   4320

acatctggga gtcaggggca caagaaaggg gcaagaacac ccaaggtacc aaaacagggt   4380

ggcatgaact gggcagacct gcttcctcct cccccagcac atcctcctcc acacagcaat   4440

agcgaagagt acaacatttc tgtagatgaa agctatgacc aagaaatgcc atgtcccgtg   4500

ccaccagcaa ggatgtattt gcaacaagat gaattagaag aggaggaaga tgaacgaggc   4560

cccactcccc ctgttcgggg agcagcttct tctccagctg ccgtgtccta tagccatcag   4620

tccactgcca ctctgactcc ctccccacag gaagaactcc agcccatgtt acaggattgt   4680

ccagaggaga ctggccacat gcagcaccag cccgacagga gacggcagcc tgtgagtcct   4740

cctccaccac cacggccgat ctcccctcca catacctatg gctacatttc aggacccctg   4800

gtctcagata tggatacgga tgcgccagaa gaggaagaag acgaagccga catggaggta   4860

gccaagatgc aaaccagaag gcttttgtta cgtgggcttg agcagacacc tgcctccagt   4920

gttggggacc tggagagctc tgtcacgggg tccatgatca acggctgggg ctcagcctca   4980

gaggaggaca acatttccag cggacgctcc agtgttagtt cttcggacgg ctcctttttc   5040

actgatgctg actttgccca ggcagtcgca gcagcggcag agtatgctgg tctgaaagta   5100

gcacgacggc aaatgcagga tgctgctggc cgtcgacatt ttcatgcgtc tcagtgccct   5160

aggcccacaa gtcccgtgtc tacagacagc aacatgagtg ccgccgtaat gcagaaaacc   5220

agaccagcca agaaactgaa acaccagcca ggacatctgc gcagagaaac ctacacagat   5280

gatcttccac cacctcctgt gccgccacct gctataaagt cacctactgc ccaatccaag   5340

acacagctgg aagtacgacc tgtagtggtg ccaaaactcc cttctatgga tgcaagaaca   5400

gacagatcat cagacagaaa aggaagcagt tacaagggga gagaagtgtt ggatggaaga   5460

caggttgttg acatgcgaac aaatccaggt gatcccagag aagcacagga acagcaaaat   5520

gacgggaaag gacgtggaaa caaggcagca aaacgagacc ttccaccagc aaagactcat   5580

ctcatccaag aggatattct accttattgt agacctactt ttccaacatc aaataatccc   5640

agagatccca gttcctcaag ctcaatgtca tcaagaggat caggaagcag acaaagagaa   5700

caagcaaatg taggtcgaag aaatattgca gaaatgcagg tacttggagg atatgaaaga   5760

ggagaagata ataatgaaga attagaggaa actgaaagct gaagacaacc aagaggctta   5820

tgagatctaa tgtgaaaatc atcactcaag atgcctcctg tcagatgaca catgacgcca   5880

gataaaatgt tcagtgcaat cagagtgtac aaattgtcgt ttttattcct cttattggga   5940

tatcatttta aaaactttat tgggttttta ttgttgttgt ttgatcccta accctacaaa   6000

gagccttcct attcccctcg ctgttggagc aaaccattat accttacttc cagcaagcaa   6060

agtgctttga cttcttgctt cagtcatcag ccagcaagag ggaacaaaac tgttcttttg   6120

cattttgccg ctgagatatg gcattgcact gcttatatgc caagctaatt tatagcaaga   6180

tattgatcaa atatagaaag ttgatattca acctcacaag ggctctcaaa gtataatctt   6240

tctatagcca actgctaatg caaattaaaa catatttcat tttaacatga tttcaaaatc   6300

agtttttcat actacccttt gctggaagaa actaaaaata tagcaaatgc agaaccacaa   6360

acaattcgaa tggggtagaa acattgtaaa tatttactct ttgcaaaccc tggtggtatt   6420

ttattttggc ttcatttcaa tcattgaagt atattcttat tggaaatgta cttttggata   6480

agtagggcta agccagttgg atctctggtt gtctagtcat tgtcataagt aaacctagta   6540

aaaccttgtt ctatttttca atcatcaaaa agtaattata aatacgtatt acaaacaagt   6600

ggatgttttt aatgaccaat tgagtaagaa catccctgtc ttaactggcc taaatttctt   6660

ctggtagtgt cagttcaact ttcagaagtg ccacttaagg aagtttgatt tttgtttttg   6720

taatgcactg tttttaatct ctctctcttt tttttttttt ttttggtttt aaaagcacaa   6780

tcactaaact ttatttgtaa accattgtaa ctattaacct tttttgtctt attgaaaaaa   6840

aaaatgttga gaagcgtttt taacctgttt tgttaatgct ctatgtttgt atttggaata   6900

tttgaataat gacagatggt gaagtaacat gcatacttta ttgtgggcca tgaaccaaat   6960

ggttcttact tttcctggac ttaaagaaaa aaagaggttt aagtttgttg tggccaatgt   7020

cgaaacctac aagatttcct taaaatctct aatagaggca ttacttgctt tcaattgaca   7080

aatgatgccc tctgactagt agatttctat gatccttttt tgtcatttta tgaatatcat   7140

tgattttata attggtgcta tttgaagaaa aaaatgtaca tttattcata gatagataag   7200

tatcaggtct gaccccagtg gaaaacaaag ccaaacaaaa ctgaaccaca aaaaaaaagg   7260

ctggtgttca ccaaaaccaa acttgttcat ttagataatt tgaaaaagtt ccatagaaaa   7320

ggcgtgcagt actaagggaa caatccatgt gattaatgtt ttcattatgt tcatgtaaga   7380

agccccttat ttttagccat aattttgcat actgaaaatc caataatcag aaaagtaatt   7440

ttgtcacatt atttattaaa aatgttctca aatac                              7475


<210>  828
<211>  1612
<212>  PRT
<213>  Homosapiens

<400>  828

Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu 
1               5                   10                  15      


Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val 
            20                  25                  30          


Glu His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu 
        35                  40                  45              


Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys 
    50                  55                  60                  


Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg 
65                  70                  75                  80  


Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly 
                85                  90                  95      


Arg Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn 
            100                 105                 110         


Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile 
        115                 120                 125             


Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val 
    130                 135                 140                 


Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu 
145                 150                 155                 160 


Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp 
                165                 170                 175     


Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg 
            180                 185                 190         


Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly 
        195                 200                 205             


Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Glu Arg Pro Ser 
    210                 215                 220                 


Phe Val Lys Arg Pro Ser Asn Leu Ala Val Thr Val Asp Asp Ser Ala 
225                 230                 235                 240 


Glu Phe Lys Cys Glu Ala Arg Gly Asp Pro Val Pro Thr Val Arg Trp 
                245                 250                 255     


Arg Lys Asp Asp Gly Glu Leu Pro Lys Ser Arg Tyr Glu Ile Arg Asp 
            260                 265                 270         


Asp His Thr Leu Lys Ile Arg Lys Val Thr Ala Gly Asp Met Gly Ser 
        275                 280                 285             


Tyr Thr Cys Val Ala Glu Asn Met Val Gly Lys Ala Glu Ala Ser Ala 
    290                 295                 300                 


Thr Leu Thr Val Gln Glu Pro Pro His Phe Val Val Lys Pro Arg Asp 
305                 310                 315                 320 


Gln Val Val Ala Leu Gly Arg Thr Val Thr Phe Gln Cys Glu Ala Thr 
                325                 330                 335     


Gly Asn Pro Gln Pro Ala Ile Phe Trp Arg Arg Glu Gly Ser Gln Asn 
            340                 345                 350         


Leu Leu Phe Ser Tyr Gln Pro Pro Gln Ser Ser Ser Arg Phe Ser Val 
        355                 360                 365             


Ser Gln Thr Gly Asp Leu Thr Ile Thr Asn Val Gln Arg Ser Asp Val 
    370                 375                 380                 


Gly Tyr Tyr Ile Cys Gln Thr Leu Asn Val Ala Gly Ser Ile Ile Thr 
385                 390                 395                 400 


Lys Ala Tyr Leu Glu Val Thr Asp Val Ile Ala Asp Arg Pro Pro Pro 
                405                 410                 415     


Val Ile Arg Gln Gly Pro Val Asn Gln Thr Val Ala Val Asp Gly Thr 
            420                 425                 430         


Phe Val Leu Ser Cys Val Ala Thr Gly Ser Pro Val Pro Thr Ile Leu 
        435                 440                 445             


Trp Arg Lys Asp Gly Val Leu Val Ser Thr Gln Asp Ser Arg Ile Lys 
    450                 455                 460                 


Gln Leu Glu Asn Gly Val Leu Gln Ile Arg Tyr Ala Lys Leu Gly Asp 
465                 470                 475                 480 


Thr Gly Arg Tyr Thr Cys Ile Ala Ser Thr Pro Ser Gly Glu Ala Thr 
                485                 490                 495     


Trp Ser Ala Tyr Ile Glu Val Gln Glu Phe Gly Val Pro Val Gln Pro 
            500                 505                 510         


Pro Arg Pro Thr Asp Pro Asn Leu Ile Pro Ser Ala Pro Ser Lys Pro 
        515                 520                 525             


Glu Val Thr Asp Val Ser Arg Asn Thr Val Thr Leu Ser Trp Gln Pro 
    530                 535                 540                 


Asn Leu Asn Ser Gly Ala Thr Pro Thr Ser Tyr Ile Ile Glu Ala Phe 
545                 550                 555                 560 


Ser His Ala Ser Gly Ser Ser Trp Gln Thr Val Ala Glu Asn Val Lys 
                565                 570                 575     


Thr Glu Thr Ser Ala Ile Lys Gly Leu Lys Pro Asn Ala Ile Tyr Leu 
            580                 585                 590         


Phe Leu Val Arg Ala Ala Asn Ala Tyr Gly Ile Ser Asp Pro Ser Gln 
        595                 600                 605             


Ile Ser Asp Pro Val Lys Thr Gln Asp Val Leu Pro Thr Ser Gln Gly 
    610                 615                 620                 


Val Asp His Lys Gln Val Gln Arg Glu Leu Gly Asn Ala Val Leu His 
625                 630                 635                 640 


Leu His Asn Pro Thr Val Leu Ser Ser Ser Ser Ile Glu Val His Trp 
                645                 650                 655     


Thr Val Asp Gln Gln Ser Gln Tyr Ile Gln Gly Tyr Lys Ile Leu Tyr 
            660                 665                 670         


Arg Pro Ser Gly Ala Asn His Gly Glu Ser Asp Trp Leu Val Phe Glu 
        675                 680                 685             


Val Arg Thr Pro Ala Lys Asn Ser Val Val Ile Pro Asp Leu Arg Lys 
    690                 695                 700                 


Gly Val Asn Tyr Glu Ile Lys Ala Arg Pro Phe Phe Asn Glu Phe Gln 
705                 710                 715                 720 


Gly Ala Asp Ser Glu Ile Lys Phe Ala Lys Thr Leu Glu Glu Ala Pro 
                725                 730                 735     


Ser Ala Pro Pro Gln Gly Val Thr Val Ser Lys Asn Asp Gly Asn Gly 
            740                 745                 750         


Thr Ala Ile Leu Val Ser Trp Gln Pro Pro Pro Glu Asp Thr Gln Asn 
        755                 760                 765             


Gly Met Val Gln Glu Tyr Lys Val Trp Cys Leu Gly Asn Glu Thr Arg 
    770                 775                 780                 


Tyr His Ile Asn Lys Thr Val Asp Gly Ser Thr Phe Ser Val Val Ile 
785                 790                 795                 800 


Pro Phe Leu Val Pro Gly Ile Arg Tyr Ser Val Glu Val Ala Ala Ser 
                805                 810                 815     


Thr Gly Ala Gly Ser Gly Val Lys Ser Glu Pro Gln Phe Ile Gln Leu 
            820                 825                 830         


Asp Ala His Gly Asn Pro Val Ser Pro Glu Asp Gln Val Ser Leu Ala 
        835                 840                 845             


Gln Gln Ile Ser Asp Val Val Lys Gln Pro Ala Phe Ile Ala Gly Ile 
    850                 855                 860                 


Gly Ala Ala Cys Trp Ile Ile Leu Met Val Phe Ser Ile Trp Leu Tyr 
865                 870                 875                 880 


Arg His Arg Lys Lys Arg Asn Gly Leu Thr Ser Thr Tyr Ala Gly Ile 
                885                 890                 895     


Arg Lys Val Pro Ser Phe Thr Phe Thr Pro Thr Val Thr Tyr Gln Arg 
            900                 905                 910         


Gly Gly Glu Ala Val Ser Ser Gly Gly Arg Pro Gly Leu Leu Asn Ile 
        915                 920                 925             


Ser Glu Pro Ala Ala Gln Pro Trp Leu Ala Asp Thr Trp Pro Asn Thr 
    930                 935                 940                 


Gly Asn Asn His Asn Asp Cys Ser Ile Ser Cys Cys Thr Ala Gly Asn 
945                 950                 955                 960 


Gly Asn Ser Asp Ser Asn Leu Thr Thr Tyr Ser Arg Pro Ala Asp Cys 
                965                 970                 975     


Ile Ala Asn Tyr Asn Asn Gln Leu Asp Asn Lys Gln Thr Asn Leu Met 
            980                 985                 990         


Leu Pro Glu Ser Thr Val Tyr Gly  Asp Val Asp Leu Ser  Asn Lys Ile 
        995                 1000                 1005             


Asn Glu  Met Lys Thr Phe Asn  Ser Pro Asn Leu Lys  Asp Gly Arg 
    1010                 1015                 1020             


Phe Val  Asn Pro Ser Gly Gln  Pro Thr Pro Tyr Ala  Thr Thr Gln 
    1025                 1030                 1035             


Leu Ile  Gln Ser Asn Leu Ser  Asn Asn Met Asn Asn  Gly Ser Gly 
    1040                 1045                 1050             


Asp Ser  Gly Glu Lys His Trp  Lys Pro Leu Gly Gln  Gln Lys Gln 
    1055                 1060                 1065             


Glu Val  Ala Pro Val Gln Tyr  Asn Ile Val Glu Gln  Asn Lys Leu 
    1070                 1075                 1080             


Asn Lys  Asp Tyr Arg Ala Asn  Asp Thr Val Pro Pro  Thr Ile Pro 
    1085                 1090                 1095             


Tyr Asn  Gln Ser Tyr Asp Gln  Asn Thr Gly Gly Ser  Tyr Asn Ser 
    1100                 1105                 1110             


Ser Asp  Arg Gly Ser Ser Thr  Ser Gly Ser Gln Gly  His Lys Lys 
    1115                 1120                 1125             


Gly Ala  Arg Thr Pro Lys Val  Pro Lys Gln Gly Gly  Met Asn Trp 
    1130                 1135                 1140             


Ala Asp  Leu Leu Pro Pro Pro  Pro Ala His Pro Pro  Pro His Ser 
    1145                 1150                 1155             


Asn Ser  Glu Glu Tyr Asn Ile  Ser Val Asp Glu Ser  Tyr Asp Gln 
    1160                 1165                 1170             


Glu Met  Pro Cys Pro Val Pro  Pro Ala Arg Met Tyr  Leu Gln Gln 
    1175                 1180                 1185             


Asp Glu  Leu Glu Glu Glu Glu  Asp Glu Arg Gly Pro  Thr Pro Pro 
    1190                 1195                 1200             


Val Arg  Gly Ala Ala Ser Ser  Pro Ala Ala Val Ser  Tyr Ser His 
    1205                 1210                 1215             


Gln Ser  Thr Ala Thr Leu Thr  Pro Ser Pro Gln Glu  Glu Leu Gln 
    1220                 1225                 1230             


Pro Met  Leu Gln Asp Cys Pro  Glu Glu Thr Gly His  Met Gln His 
    1235                 1240                 1245             


Gln Pro  Asp Arg Arg Arg Gln  Pro Val Ser Pro Pro  Pro Pro Pro 
    1250                 1255                 1260             


Arg Pro  Ile Ser Pro Pro His  Thr Tyr Gly Tyr Ile  Ser Gly Pro 
    1265                 1270                 1275             


Leu Val  Ser Asp Met Asp Thr  Asp Ala Pro Glu Glu  Glu Glu Asp 
    1280                 1285                 1290             


Glu Ala  Asp Met Glu Val Ala  Lys Met Gln Thr Arg  Arg Leu Leu 
    1295                 1300                 1305             


Leu Arg  Gly Leu Glu Gln Thr  Pro Ala Ser Ser Val  Gly Asp Leu 
    1310                 1315                 1320             


Glu Ser  Ser Val Thr Gly Ser  Met Ile Asn Gly Trp  Gly Ser Ala 
    1325                 1330                 1335             


Ser Glu  Glu Asp Asn Ile Ser  Ser Gly Arg Ser Ser  Val Ser Ser 
    1340                 1345                 1350             


Ser Asp  Gly Ser Phe Phe Thr  Asp Ala Asp Phe Ala  Gln Ala Val 
    1355                 1360                 1365             


Ala Ala  Ala Ala Glu Tyr Ala  Gly Leu Lys Val Ala  Arg Arg Gln 
    1370                 1375                 1380             


Met Gln  Asp Ala Ala Gly Arg  Arg His Phe His Ala  Ser Gln Cys 
    1385                 1390                 1395             


Pro Arg  Pro Thr Ser Pro Val  Ser Thr Asp Ser Asn  Met Ser Ala 
    1400                 1405                 1410             


Ala Val  Met Gln Lys Thr Arg  Pro Ala Lys Lys Leu  Lys His Gln 
    1415                 1420                 1425             


Pro Gly  His Leu Arg Arg Glu  Thr Tyr Thr Asp Asp  Leu Pro Pro 
    1430                 1435                 1440             


Pro Pro  Val Pro Pro Pro Ala  Ile Lys Ser Pro Thr  Ala Gln Ser 
    1445                 1450                 1455             


Lys Thr  Gln Leu Glu Val Arg  Pro Val Val Val Pro  Lys Leu Pro 
    1460                 1465                 1470             


Ser Met  Asp Ala Arg Thr Asp  Arg Ser Ser Asp Arg  Lys Gly Ser 
    1475                 1480                 1485             


Ser Tyr  Lys Gly Arg Glu Val  Leu Asp Gly Arg Gln  Val Val Asp 
    1490                 1495                 1500             


Met Arg  Thr Asn Pro Gly Asp  Pro Arg Glu Ala Gln  Glu Gln Gln 
    1505                 1510                 1515             


Asn Asp  Gly Lys Gly Arg Gly  Asn Lys Ala Ala Lys  Arg Asp Leu 
    1520                 1525                 1530             


Pro Pro  Ala Lys Thr His Leu  Ile Gln Glu Asp Ile  Leu Pro Tyr 
    1535                 1540                 1545             


Cys Arg  Pro Thr Phe Pro Thr  Ser Asn Asn Pro Arg  Asp Pro Ser 
    1550                 1555                 1560             


Ser Ser  Ser Ser Met Ser Ser  Arg Gly Ser Gly Ser  Arg Gln Arg 
    1565                 1570                 1575             


Glu Gln  Ala Asn Val Gly Arg  Arg Asn Ile Ala Glu  Met Gln Val 
    1580                 1585                 1590             


Leu Gly  Gly Tyr Glu Arg Gly  Glu Asp Asn Asn Glu  Glu Leu Glu 
    1595                 1600                 1605             


Glu Thr  Glu Ser 
    1610         


<210>  829
<211>  7299
<212>  DNA
<213>  Homosapiens

<400>  829
aggagattga gaccatcctg gctaacacgg tgaaaccccg tctctactaa aaatacaaaa     60

aaattagccg ggcgtggcgg cgggcgcctg tagtcccagc tacttgggag gctgaggcag    120

gagaatggtg cgaacccggg aggcagattt tgcagagagc cgagatcgtg ccactgcact    180

ccagcctggg cgacagagca agactccgtc tcaaaacaaa aaacaaacaa acaaatatgg    240

agcattctga tatgaataag acacttgctc acttctcaat tccttggtgt ccagctctac    300

aagtgtatat agacttccaa agaatattta aatcctttaa caaaaatgcc acctaagaaa    360

atatgaaata cttcagtctg tctgtcagtg ctcacttcct gtctagaaac tttcaggctc    420

cggcacaaat gaaccatgtt cttcgcctaa gtcatttatg gaacatctgc tttcggttta    480

gcatcagtgt gctattaatc caggtcttcc aagaaacaaa tgccaagatg gtattaaaca    540

tgaaatgatt ttaattgttt acatgcctga aagtaaataa agagggtgcc agctaaggct    600

gaaaaagtct tcagtgatat aaattttacc acacttaaag agagagagga aaagtttaag    660

tggaagctcc tactcagcca tgctgtctaa ggaagatttg gcaaaacctt gagctaaagt    720

cagccaacgg aaatcccacc tttctccaaa gaatggatct gctttactat cttgcttggt    780

cttattgctt tgtgacctag taatatcttt ctcgagtgca tgaaacatct cagaaatgca    840

aacatcaagg aagatactaa tcctttcttc cagtttctgt gtgagggttg gaggctgact    900

ttggtggtga tcttgctcca aattatagaa ctacatcctg tcatgaagag aagtttgtct    960

tctcgataaa gccaagtagc taacagagat ggtcacccca attaccagat ggacataatt   1020

atacttgaat gctgacctac aacattttgt gctgtgcaga ggctttgaaa atcaaacaac   1080

tttgaaaata caaagcaccg cgtggatggc ctcactctgt cgctcaggct ggagtggcac   1140

gatcttggct cactgcagtc tctgcctcct cctcttggat gcaagcaatt cggcctccaa   1200

gtagctgaga ttacagagag gctgaaaact caagaaatgt ggactaagtg tgtgggcaag   1260

tgtgtcactg ctgactaaaa ctatgaacag acagagtctc actctgtcat ccaggctgga   1320

gtccagtggt atgatcttgg ctcactgcaa acctttgcct ccctggtcca agtgattctc   1380

ctgcttcagc ctccaaaagt agctaggact acagctaatc ctagtgaatc ctccatgagg   1440

ccattgttct gaatggaaga agagagatat atgcaatagg aaaaggtgac gtggaatcta   1500

tgagagtccc atgtttatgt agcatattgt gcctactgta tctattcagg aggggattct   1560

taatataaga gatacattta caaaattgct tccattacct acaaacacca taaagaaaag   1620

taacagtgat gcatatggac agaactgcat caccagaagt tagaggagga aagcatttcc   1680

tatccaactt taaatgctga gaatgaataa ccaggaaaaa tggtacagag gacaaaatac   1740

caacaaaagt ctccaaaagt gatgtgaaga aaataagggg ctcatcattc taaattctgc   1800

aggagagcag tagaagaaat caagggaatc ccacattatg tgggactctg cgactgtatt   1860

ggacacatag aataatctag gataatctct ctgtctcaag atcttcaaat gaatcgcagc   1920

tgtaacgtcc cttttgccag ggaaggcaat atattcacag attctgagga ttaggaatga   1980

gacctccttg gagccattgt ttaacctttc ataggctgga taatatagtt ttgcaaactc   2040

aatttgggca gctggacagt gatcaggcaa ctttccgagt ccctgactcc cacctagact   2100

gagattccaa tgctaggtgc ccagaagttt ccaaccaatg caaaggtggc agctggcaag   2160

ggccctgtgc agcagtaagg cgagtcatag actgatgaga gatcaccatt gggaatgagc   2220

tccatttgcc cacaacagtg atcggctgat ggctccaccc tctacttagt cgcttctgtt   2280

tcctgtccca tggattcctc accccacact aatgcttcca ggaacaactt ctcaaataaa   2340

tcacttgcac atttctagat gatatgaatt atattcagac ctgaagagag gacagaaaaa   2400

ttctggactt caaactcaat gcaatgattg gataagactt tcggagtaac ttcttttggg   2460

attgcgtaag agatcaagac tacagacttt gaggtaaaaa caacctagat tcgtgagaag   2520

aggaagagta aaagaactgc agctttcctc ccactcttaa ggtataaata tgaagtctag   2580

gtcatttcga gttggagaag ccccagctac ttcataagtg tgatgctagt tttgaatgtg   2640

cattgaggga cagctggtgt tgagaaaaaa ggaaattacc ttaataccaa taatttcagc   2700

acagattgtc atgtggttgg gaaaatattt gatatgaaga cattgaatcc accttctaaa   2760

gaataacaag atatattcat gaatggaagg atttggtagg gtacatgagg acagatataa   2820

aactgcacaa ccaatgttac acaaaggagg tttattcttc ttcacaagaa agtgatgtgt   2880

agagatattc actgaattat tgaagattat atgtggcaga gtcagcttgg ggatccaggt   2940

tgtctaatcc aaagattgtt taaccaagaa acaaggtcaa ggcatgttct tcgatgcttg   3000

ttcattaaca gctctgcggg tgatgctcct agagaggtct gatgtgttgt gtgatgttct   3060

cacacaaact atgttaattt ttgatcagtg attgtgagtt ttaattgtgt tgaggtaact   3120

agagatttgt taagtggacg ttacttcaaa aaggtaagtt gaagcagtaa atgttaaaac   3180

caaggaatcc cccaaattct tgccctttat tttttgcatg ttaattccag aaaagaaaaa   3240

aaaaaaagct tgtgggttaa cgtggtattt atgcaaggct gccaatgtaa atataattct   3300

gtgatttaat tttttactgg catgacatta tatatatgta taaaatgtgc atacataata   3360

tatacatatg tatatatgtt atatattaga tgtgtatgca tatataatat atattagatg   3420

tataaaatat attacatata taataaaata ttagatatgt attatatagt agtatatata   3480

aaatatatac atatctaata atacattata gatcatgtat taatatatac atatatctag   3540

tatatacaat atatacatat ctattatatt tatacacaca tacatataca tatgtgtatg   3600

tgtatgtctg tgcctgtgtg tctttttgtc ttgcaagctc aatctttaaa aagaagagtt   3660

cgaggaggga tggagaagga agagagtgat tatatataca tatactgtcc atgtttgctt   3720

agctagtatg aagcagaatc tggattcaaa ttcaagaagt ctgattccca aacagccacc   3780

caattaggac cgctttgaaa actccgagtc ttctatttga tataagtata gctcattgcc   3840

atggaaataa acatatgttt cttttttaaa ttaaaaaaaa tatttttatt ttgttttcaa   3900

catttagcat ttttttgcat caaagttcta agtagctgca tgtctgttta taatgtgtat   3960

atttgttgtt tgtttttctg ttttgtttct gtatagtttc tttgtttgta tcactggtaa   4020

tttaatccct catgctatgc tgtgggatta tgtacaacaa cacaacttct tagcctcttc   4080

aaaccctttc actgcaagct gcttttttgt gctttttgaa agaaaaggaa gaaaaacaca   4140

ttgcattttc ttaagataaa atgatacctg cttcttcatt tcctcctact ccttcctatt   4200

atcttttgta gaaagaattg ctgaatctat tgatatgtaa ttttcattta attctccaac   4260

atcttattgc tatttaaaat ggtttaagaa aactggctta atatagccaa gaaaaattct   4320

atagtaatac ttgtctgtaa tttctctata tttaaataaa atatcatttc tatcttggag   4380

gtttgatttg gccatttaaa aatgctaatg ttttattgtt ttttcaaaaa aatactacat   4440

gcatgctcat agtataaaca tcaatgtttc attaggatat atagtgaaaa gtcagtaact   4500

ttacaacctc tgtttcaaac ccaaccagta atttaagttg ttttcataac aaagtgttat   4560

tatttatctt ctaataccta taaaatattt atttactccc caaattaaat agagtgttgg   4620

ttcttcaatg aaggtatgaa gttactttca attaaatatg cagtttgatt agaagaaaaa   4680

aaaatccatc agatctcagc caagctcttt tggatgatta tttttcttca aaatcaaata   4740

cactaaaatt tccaaacagt aacagttaca atgtttcagt ttcttttaag gtagcctgaa   4800

ctgagacaca ttaaggttta tatctaattt catagttctg ttcagtagga aataagtaaa   4860

ttagtttaaa ggactgatcc atatcaggag atcaggactg gacaaagtgt taatttatct   4920

acagatttta ccaggcagat tgccaatatc caagttcatt agacaggtcc taggactaat   4980

aagaactctt gggggctaca atgtgaaata cctgagtata tgagtcaggt aaagacttta   5040

gaaagtttgg cttctactct catattccca ggagttgaat agattggagt ggaaaaaatg   5100

tggtcaaaaa ctagtgattt tggattagaa gtagggcata aagctcctat tattgcactt   5160

gggcaatatt aactggattg caagaaactg taatatgcag aaacagcata tttcccttag   5220

ggagtacatt ttgttaaact tagtattctt gctacctgtt ttgttaccta agcttaatgg   5280

acctggccct agactttagc ttggtgcatg gtgaaaattg accttaagca actgcagcat   5340

tgtccaaata tttggtttca catagaccag ttttggttct tgtttctgtg tgactttgag   5400

gggctcttta agaaatccaa ggacaaggtg ccacatttat taaggccccg ccattcacaa   5460

tgcatgatgc tagagcctga cagtgcacca tgctagagac tgaagagaca taaaaaaaag   5520

aaaaggcaga gttcttgcta tcaggttctt aaaattttct ttgttttggt taaattcttg   5580

attggatttt ttcactaaat gtttggccct attaaaaata agtaaagaaa aaatgaagga   5640

agaatggaag agagggagaa taggaaatga atgaaacaaa gccaagtaag agatacgtct   5700

actacagacc tgcaagttgg cagtgcttgc agaagacagt tgacatattc tagcctggtt   5760

cacattttct ggttaacttt tgagcataga ataaagaata taataaaatg cttttttttt   5820

tttttgcaca atgaacttta aacaaatcag gagagtatat tggtaattta gagaagtagc   5880

aattctcatt aaatctgttt ttcattgaat tatcatgccc ttaaaattat atgatagatt   5940

attatcttcg gtagtattag tttaaataag aattatatac aaccaaaata tcagtaaggc   6000

taattctctg agaccataag agaaccaagt caatatcccc atagctacat catattgatc   6060

attcatttga tttaagaaga aagaagacaa atatgttagt gaaagggaga caaatgagta   6120

tgtgcctggc ctggccaatt cctgactcat ttacagagga agctaatata actctcttac   6180

tcattttatg ggaaatatga tagatctgat tatataattt atgcctcctt tcagacttcc   6240

tacaccccac taattgtctc ttcctttctt ttctccacct tttgctcagg tatttggcag   6300

ttattgcact tttttggatc ttttttttaa ggatgttact atcaatcttt tgcctacatc   6360

taaatgactt acctatgaag aagatcccat ttttagcctt aatatttgca aattacttga   6420

gagatggagt ctcactctat cacccaggct ggaggacagt ggcacgacct cagctccctg   6480

caacctccac ctcccaggtt actgatggat ccgtcctaaa tgccatccat ctcaagacag   6540

aggcccacag aagtcaatgt atcttcaaga tgggagtacc tggagatggc tgtagagacc   6600

atgtagcagg aaatggtgac agagaagagc tgggcctctg gtaccaacat gcttcccccc   6660

cgttacagct atgcgggctg atagtgacgc aatgtgtggt ttcaatactt catagtgtct   6720

tacttcacct cagtataaag tactttgaaa gcatcaagga aatggtcctc aaaaaaggct   6780

tatccagtca ggacatctgg tgctggctct ggaatgagtg gatgaagata aggccttcca   6840

gtatggaggt gataaaaatc agggaagaca ggtaatcaca atggatgaca gaccaggatt   6900

cccagatatc ttggcatggc tggaacaatg tacagatcaa accatgtaaa acttaatggg   6960

tataaaccaa ctcttcactt tggtctaaaa aagtccattt gcatggcttc tagttaaagg   7020

tggacaggct cactttagaa tcctattata tacaaaggat ttagggggtt tagttcacaa   7080

tgtgctaaag ccatctcaca gtgaccatgg tatgagctgt gtgatttggt ttaaatataa   7140

tagagaatga aggacaaggt tgagggtggt ggttacagtc ctgcctgatt ctgtagtgct   7200

caggtgacct ttgaagaatg aagaaagaag tcaaaacccc acactattaa gacattggaa   7260

gactgggaat gtttattttc tgaagaataa aagatgtag                          7299


<210>  830
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  830

Met Lys Tyr Phe Ser Leu Ser Val Ser Ala His Phe Leu Ser Arg Asn 
1               5                   10                  15      


Phe Gln Ala Pro Ala Gln Met Asn His Val Leu Arg Leu Ser His Leu 
            20                  25                  30          


Trp Asn Ile Cys Phe Arg Phe Ser Ile Ser Val Leu Leu Ile Gln Val 
        35                  40                  45              


Phe Gln Glu Thr Asn Ala Lys Met Val Leu Asn Met Lys 
    50                  55                  60      


<210>  831
<211>  3976
<212>  DNA
<213>  Homosapiens

<400>  831
ctgggtcctg tgtgtgccac aggggtgggg tgtccagcga gcggtctcct cctcctgcta     60

gtgctgctgc ggcgtcccgc ggcctccccg agtcgggcgg gaggggagag cgggtgtgga    120

tttgtcttga cggtaattgt tgcgtttcca cgtctcggag gcctgcgcgc tgggttgctc    180

cttcttcggg agcgagctgt tctcagcgat cccactccca gccggggctc cccacacaca    240

ctgggctgcg tgcgtgtgga gtgggacccg cgcacacgcg tgtctctgga cagctacggc    300

gccgaaagaa ctaaaattcc agatggcaaa ctcaatgaat ggcagaaacc ctggtggtcg    360

aggaggaaat ccccgaaaag gtcgaatttt gggtattatt gatgctattc aggatgcagt    420

tggaccccct aagcaagctg ccgcagatcg caggaccgtg gagaagactt ggaagctcat    480

ggacaaagtg gtaagactgt gccaaaatcc caaacttcag ttgaaaaata gcccaccata    540

tatacttgat attttgcctg atacatatca gcatttacga cttatattga gtaaatatga    600

tgacaaccag aaacttgccc aactcagtga gaatgagtac tttaaaatct acattgatag    660

ccttatgaaa aagtcaaaac gggcaataag actctttaaa gaaggcaagg agagaatgta    720

tgaagaacag tcacaggaca gacgaaatct cacaaaactg tcccttatct tcagtcacat    780

gctggcagaa atcaaagcaa tctttcccaa tggtcaattc cagggagata actttcgtat    840

cacaaaagca gatgctgctg aattctggag aaagtttttt ggagacaaaa ctatcgtacc    900

atggaaagta ttcagacagt gccttcatga ggtccaccag attagctctg gcctggaagc    960

aatggctcta aaatcaacaa ttgatttaac ttgcaatgat tacatttcag tttttgaatt   1020

tgatattttt accaggctgt ttcagccttg gggctctatt ttgcggaatt ggaatttctt   1080

agctgtgaca catccaggtt acatggcatt tctcacatat gatgaagtta aagcacgact   1140

acagaaatat agcaccaaac ccggaagcta tattttccgg ttaagttgca ctcgattggg   1200

acagtgggcc attggctatg tgactgggga tgggaatatc ttacagacca tacctcataa   1260

caagccctta tttcaagccc tgattgatgg cagcagggaa ggattttatc tttatcctga   1320

tgggaggagt tataatcctg atttaactgg attatgtgaa cctacacctc atgaccatat   1380

aaaagttaca caggaacaat atgaattata ttgtgaaatg ggctccactt ttcagctctg   1440

taagatttgt gcagagaatg acaaagatgt caagattgag ccttgtgggc atttgatgtg   1500

cacctcttgc cttacggcat ggcaggagtc ggatggtcag ggctgccctt tctgtcgttg   1560

tgaaataaaa ggaactgagc ccataatcgt ggaccccttt gatccaagag atgaaggctc   1620

caggtgttgc agcatcattg acccctttgg catgccgatg ctagacttgg acgacgatga   1680

tgatcgtgag gagtccttga tgatgaatcg gttggcaaac gtccgaaagt gcactgacag   1740

gcagaactca ccagtcacat caccaggatc ctctcccctt gcccagagaa gaaagccaca   1800

gcctgaccca ctccagatcc cacatctaag cctgccaccc gtgcctcctc gcctggatct   1860

aattcagaaa ggcatagtta gatctccctg tggcagccca acgggttcac caaagtcttc   1920

tccttgcatg gtgagaaaac aagataaacc actcccagca ccacctcctc ccttaagaga   1980

tcctcctcca ccgccacctg aaagacctcc accaatccca ccagacaata gactgagtag   2040

acacatccat catgtggaaa gcgtgccttc cagagacccg ccaatgcctc ttgaagcatg   2100

gtgccctcgg gatgtgtttg ggactaatca gcttgtggga tgtcgactcc taggggaggg   2160

ctctccaaaa cctggaatca cagcgagttc aaatgtcaat ggaaggcaca gtagagtggg   2220

ctctgaccca gtgcttatgc ggaaacacag acgccatgat ttgcctttag aaggagctaa   2280

ggtcttttcc aatggtcacc ttggaagtga agaatatgat gttcctcccc ggctttctcc   2340

tcctcctcca gttaccaccc tcctccctag cataaagtgt actggtccgt tagcaaattc   2400

tctttcagag aaaacaagag acccagtaga ggaagatgat gatgaataca agattccttc   2460

atcccaccct gtttccctga attcacaacc atctcattgt cataatgtaa aacctcctgt   2520

tcggtcttgt gataatggtc actgtatgct gaatggaaca catggtccat cttcagagaa   2580

gaaatcaaac atccctgact taagcatata tttaaaggga gatgtttttg attcagcctc   2640

tgatcccgtg ccattaccac ctgccaggcc tccaactcgg gacaatccaa agcatggttc   2700

ttcactcaac aggacgccct ctgattatga tcttctcatc cctccattag gtgaagatgc   2760

ttttgatgcc ctccctccat ctctcccacc tcccccacct cctgcaaggc atagtctcat   2820

tgaacattca aaacctcctg gctccagtag ccggccatcc tcaggacagg atctttttct   2880

tcttccttca gatccctttg ttgatctagc aagtggccaa gttcctttgc ctcctgctag   2940

aaggttacca ggtgaaaatg tcaaaactaa cagaacatca caggactatg atcagcttcc   3000

ttcatgttca gatggttcac aggcaccagc cagaccccct aaaccacgac cgcgcaggac   3060

tgcaccagaa attcaccaca gaaaacccca tgggcctgag gcggcattgg aaaatgtcga   3120

tgcaaaaatt gcaaaactca tgggagaggg ttatgccttt gaagaggtga agagagcctt   3180

agagatagcc cagaataatg tcgaagttgc ccggagcatc ctccgagaat ttgccttccc   3240

tcctccagta tccccacgtc taaatctata gcagccagaa ctgtagacac caaaatggaa   3300

agcaatcgat gtattccaag agtgtggaaa taaagagaac tgagatggaa ttcaagagag   3360

aagtgtctcc tcctcgtgta gcagcttgag aagaggcttg ggagtgcagc ttctcaaagg   3420

agaccgatgc ttgctcagga tgtcgacagc tgtggcttcc ttgtttttgc tagccatatt   3480

tttaaatcag ggttgaactg acaaaaataa tttaaagacg tttacttccc ttgaactttg   3540

aacctgtgaa atgctttacc ttgtttacag tttggcaaag ttgcagtttg ttcttgtttt   3600

tagtttagtt ttgttttggt gttttgatac ctgtactgtg ttcttcacag accctttgta   3660

gcgtggtcag gtctgctgta acatttccca ccaactctct tgctgtccac atcaacagct   3720

aaatcattta ttcatatgga tctctaccat ccccatgcct tgcccaggtc cagttccatt   3780

tctctcattc acaagatgct ttgaaggttc tgattttcaa ctgatcaaac taatgcaaaa   3840

aaaaaaaagt atgtattctt cactactgag tttcttcttt ggaaaccatc actattgaga   3900

gatgggaaaa acctgaatgt ataaagcatt tatttgtcaa taaactgcct tttgtaaggg   3960

gttttcacat aacata                                                   3976


<210>  832
<211>  982
<212>  PRT
<213>  Homosapiens

<400>  832

Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn 
1               5                   10                  15      


Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala 
            20                  25                  30          


Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Thr Val Glu Lys 
        35                  40                  45              


Thr Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys 
    50                  55                  60                  


Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp 
65                  70                  75                  80  


Thr Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln 
                85                  90                  95      


Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp 
            100                 105                 110         


Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly 
        115                 120                 125             


Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Thr 
    130                 135                 140                 


Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile 
145                 150                 155                 160 


Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Thr Lys Ala 
                165                 170                 175     


Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Thr Ile Val 
            180                 185                 190         


Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser 
        195                 200                 205             


Ser Gly Leu Glu Ala Met Ala Leu Lys Ser Thr Ile Asp Leu Thr Cys 
    210                 215                 220                 


Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Thr Arg Leu Phe 
225                 230                 235                 240 


Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Thr 
                245                 250                 255     


His Pro Gly Tyr Met Ala Phe Leu Thr Tyr Asp Glu Val Lys Ala Arg 
            260                 265                 270         


Leu Gln Lys Tyr Ser Thr Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser 
        275                 280                 285             


Cys Thr Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Thr Gly Asp Gly 
    290                 295                 300                 


Asn Ile Leu Gln Thr Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu 
305                 310                 315                 320 


Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser 
                325                 330                 335     


Tyr Asn Pro Asp Leu Thr Gly Leu Cys Glu Pro Thr Pro His Asp His 
            340                 345                 350         


Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser 
        355                 360                 365             


Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys 
    370                 375                 380                 


Ile Glu Pro Cys Gly His Leu Met Cys Thr Ser Cys Leu Thr Ala Trp 
385                 390                 395                 400 


Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys 
                405                 410                 415     


Gly Thr Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly 
            420                 425                 430         


Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp 
        435                 440                 445             


Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu 
    450                 455                 460                 


Ala Asn Val Arg Lys Cys Thr Asp Arg Gln Asn Ser Pro Val Thr Ser 
465                 470                 475                 480 


Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro 
                485                 490                 495     


Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp 
            500                 505                 510         


Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Thr Gly 
        515                 520                 525             


Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu 
    530                 535                 540                 


Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu 
545                 550                 555                 560 


Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His 
                565                 570                 575     


His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala 
            580                 585                 590         


Trp Cys Pro Arg Asp Val Phe Gly Thr Asn Gln Leu Val Gly Cys Arg 
        595                 600                 605             


Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Thr Ala Ser Ser Asn 
    610                 615                 620                 


Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg 
625                 630                 635                 640 


Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser 
                645                 650                 655     


Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser 
            660                 665                 670         


Pro Pro Pro Pro Val Thr Thr Leu Leu Pro Ser Ile Lys Cys Thr Gly 
        675                 680                 685             


Pro Leu Ala Asn Ser Leu Ser Glu Lys Thr Arg Asp Pro Val Glu Glu 
    690                 695                 700                 


Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn 
705                 710                 715                 720 


Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys 
                725                 730                 735     


Asp Asn Gly His Cys Met Leu Asn Gly Thr His Gly Pro Ser Ser Glu 
            740                 745                 750         


Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Asp Val 
        755                 760                 765             


Phe Asp Ser Ala Ser Asp Pro Val Pro Leu Pro Pro Ala Arg Pro Pro 
    770                 775                 780                 


Thr Arg Asp Asn Pro Lys His Gly Ser Ser Leu Asn Arg Thr Pro Ser 
785                 790                 795                 800 


Asp Tyr Asp Leu Leu Ile Pro Pro Leu Gly Glu Asp Ala Phe Asp Ala 
                805                 810                 815     


Leu Pro Pro Ser Leu Pro Pro Pro Pro Pro Pro Ala Arg His Ser Leu 
            820                 825                 830         


Ile Glu His Ser Lys Pro Pro Gly Ser Ser Ser Arg Pro Ser Ser Gly 
        835                 840                 845             


Gln Asp Leu Phe Leu Leu Pro Ser Asp Pro Phe Val Asp Leu Ala Ser 
    850                 855                 860                 


Gly Gln Val Pro Leu Pro Pro Ala Arg Arg Leu Pro Gly Glu Asn Val 
865                 870                 875                 880 


Lys Thr Asn Arg Thr Ser Gln Asp Tyr Asp Gln Leu Pro Ser Cys Ser 
                885                 890                 895     


Asp Gly Ser Gln Ala Pro Ala Arg Pro Pro Lys Pro Arg Pro Arg Arg 
            900                 905                 910         


Thr Ala Pro Glu Ile His His Arg Lys Pro His Gly Pro Glu Ala Ala 
        915                 920                 925             


Leu Glu Asn Val Asp Ala Lys Ile Ala Lys Leu Met Gly Glu Gly Tyr 
    930                 935                 940                 


Ala Phe Glu Glu Val Lys Arg Ala Leu Glu Ile Ala Gln Asn Asn Val 
945                 950                 955                 960 


Glu Val Ala Arg Ser Ile Leu Arg Glu Phe Ala Phe Pro Pro Pro Val 
                965                 970                 975     


Ser Pro Arg Leu Asn Leu 
            980         


<210>  833
<211>  1884
<212>  DNA
<213>  Homosapiens

<400>  833
gccttgcaca tggagatgct tagctgaggg ggtggctttg ttagactatt tgcaggtcgt     60

gagatagagc ctgagatggg ggactgggcc cctgcctggg ggattgggtc gtgacctgtg    120

tggagcccca cactgagctg cagtgggtgg ggagggtggt ttacaggggt gctctgtgca    180

gcccctctga ttttcccctg ggagtcccag gtccagggga aggaggacag tggcccaggc    240

cacacagctc actgggcggc tctcactccc ccagggctgg ctgctggcgg gatggacacc    300

ctggaggagg tgacttgggc caatgggagc acagcgctac ccccacccct ggcaccaaac    360

atcagtgtgc ctcatcgctg cctgctgctg ctctacgaag acattggcac ctccagggtc    420

cggtactggg acctcttgct gctcatcccc aatgtgctct tcctcatctt cctgctctgg    480

aagcttccat ctgctcgggc gaagatccgc atcacctcca gccccatttt tatcaccttc    540

tacatcctgg tgtttgtggt ggcgctggtg ggcattgccc gggccgtggt atccatgacg    600

gtgagcacct cgaacgctgc aactgttgct gataagatcc tgtgggagat cacccgcttc    660

ttcctgctgg ccatcgagct gagtgtgatc atcctgggcc tggcctttgg cacctgggag    720

agtaagtcca gcatcaagcg ggtgctggcc atcaccacag tgctgtccct ggcctactct    780

gtcacccagg ggaccctgga gatcctgtac cctgatgccc atctctcagc tgaggacttt    840

aatatctatg gccatggggg ccgccagttc tggctggtca gctcctgctt cttcttcctg    900

gtctactctc tggtggtcat ccttcccaag accccgctga aggagcgcat ctccctgcct    960

tctcggagga gcttctacgt gtatgcgggc atcctggcac tgctcaacct actgcagggg   1020

ctggggagtg tgctgctgtg cttcgacatc atcgaggggc tctgctgtgt agatgccaca   1080

accttcctgt acttcagctt cttcgctccg ctcatctacg tggctttcct ccggggcttc   1140

ttcggctcgg agcccaagat cctcttctcc tacaaatgcc aagtggacga gacagaggag   1200

ccagatgtac acctacccca gccctacgct gtggcccggc gggagggcct ggaggctgca   1260

ggggctgctg gggcctcagc tgccagctac tcgagcacgc agttcgactc tgccggcggg   1320

gtggcctacc tggatgacat cgcttccatg ccctgccaca ctggcagcat caacagcaca   1380

gacagcgagc gctggaaggc catcaatgcc tgagggcagc tgccagggcc tgtggaggac   1440

aggccagaga ggaggccagc aggcccagag tccccagggg aggaggacca ggtcaaggga   1500

cgttctgtgg gcagtagccc tgtgtggccc tgttcccacc atgagtctgg aggccccacc   1560

tccctggggc tcccaatccc ctttgccatc tctgctctca ctggggaccc tcctcccctt   1620

cccacctgct ctcatactgc tcagtgacat ggcccaggct ttccttccag ggccatgctt   1680

ggcaaggttg gctgagggca ccctccttct ctgcaccctt ggcacgaggg cagggctggc   1740

tctcccaatg cctccatccc atccccatgg tgctttggcc tcctcaaagc atccaccatg   1800

gtggatggac tgaagtgtgt atattttctt gatctatttt ttaataaaaa ggaaaaggag   1860

caaaaaaaaa aaaaaaaagt tttg                                          1884


<210>  834
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  834

Met Asp Thr Leu Glu Glu Val Thr Trp Ala Asn Gly Ser Thr Ala Leu 
1               5                   10                  15      


Pro Pro Pro Leu Ala Pro Asn Ile Ser Val Pro His Arg Cys Leu Leu 
            20                  25                  30          


Leu Leu Tyr Glu Asp Ile Gly Thr Ser Arg Val Arg Tyr Trp Asp Leu 
        35                  40                  45              


Leu Leu Leu Ile Pro Asn Val Leu Phe Leu Ile Phe Leu Leu Trp Lys 
    50                  55                  60                  


Leu Pro Ser Ala Arg Ala Lys Ile Arg Ile Thr Ser Ser Pro Ile Phe 
65                  70                  75                  80  


Ile Thr Phe Tyr Ile Leu Val Phe Val Val Ala Leu Val Gly Ile Ala 
                85                  90                  95      


Arg Ala Val Val Ser Met Thr Val Ser Thr Ser Asn Ala Ala Thr Val 
            100                 105                 110         


Ala Asp Lys Ile Leu Trp Glu Ile Thr Arg Phe Phe Leu Leu Ala Ile 
        115                 120                 125             


Glu Leu Ser Val Ile Ile Leu Gly Leu Ala Phe Gly Thr Trp Glu Ser 
    130                 135                 140                 


Lys Ser Ser Ile Lys Arg Val Leu Ala Ile Thr Thr Val Leu Ser Leu 
145                 150                 155                 160 


Ala Tyr Ser Val Thr Gln Gly Thr Leu Glu Ile Leu Tyr Pro Asp Ala 
                165                 170                 175     


His Leu Ser Ala Glu Asp Phe Asn Ile Tyr Gly His Gly Gly Arg Gln 
            180                 185                 190         


Phe Trp Leu Val Ser Ser Cys Phe Phe Phe Leu Val Tyr Ser Leu Val 
        195                 200                 205             


Val Ile Leu Pro Lys Thr Pro Leu Lys Glu Arg Ile Ser Leu Pro Ser 
    210                 215                 220                 


Arg Arg Ser Phe Tyr Val Tyr Ala Gly Ile Leu Ala Leu Leu Asn Leu 
225                 230                 235                 240 


Leu Gln Gly Leu Gly Ser Val Leu Leu Cys Phe Asp Ile Ile Glu Gly 
                245                 250                 255     


Leu Cys Cys Val Asp Ala Thr Thr Phe Leu Tyr Phe Ser Phe Phe Ala 
            260                 265                 270         


Pro Leu Ile Tyr Val Ala Phe Leu Arg Gly Phe Phe Gly Ser Glu Pro 
        275                 280                 285             


Lys Ile Leu Phe Ser Tyr Lys Cys Gln Val Asp Glu Thr Glu Glu Pro 
    290                 295                 300                 


Asp Val His Leu Pro Gln Pro Tyr Ala Val Ala Arg Arg Glu Gly Leu 
305                 310                 315                 320 


Glu Ala Ala Gly Ala Ala Gly Ala Ser Ala Ala Ser Tyr Ser Ser Thr 
                325                 330                 335     


Gln Phe Asp Ser Ala Gly Gly Val Ala Tyr Leu Asp Asp Ile Ala Ser 
            340                 345                 350         


Met Pro Cys His Thr Gly Ser Ile Asn Ser Thr Asp Ser Glu Arg Trp 
        355                 360                 365             


Lys Ala Ile Asn Ala 
    370             


<210>  835
<211>  3453
<212>  DNA
<213>  Homosapiens

<400>  835
acttttcgcg cgaaacctgg ttgttgctgt agtggcggag aggatcgtgg tactgctatg     60

gcggaatcat cggaatcctt caccatggca tccagcccgg cccagcgtcg gcgaggcaat    120

gatcctctca cctccagccc tggccgaagc tcccggcgta ctgatgccct cacctccagc    180

cctggccgtg accttccacc atttgaggat gagtccgagg ggctcctagg cacagagggg    240

cccctggagg aagaagagga tggagaggag ctcattggag atggcatgga aagggactac    300

cgcgccatcc cagagctgga cgcctatgag gccgagggac tggctctgga tgatgaggac    360

gtagaggagc tgacggccag tcagagggag gcagcagagc gggccatgcg gcagcgtgac    420

cgggaggctg gccggggcct gggccgcatg cgccgtgggc tcctgtatga cagcgatgag    480

gaggacgagg agcgccctgc ccgcaagcgc cgccaggtgg agcgggccac ggaggacggc    540

gaggaggacg aggagatgat cgagagcatc gagaacctgg aggatctcaa aggccactct    600

gtgcgcgagt gggtgagcat ggcgggcccc cggctggaga tccaccaccg cttcaagaac    660

ttcctgcgca ctcacgtcga cagccacggc cacaacgtct tcaaggagcg catcagcgac    720

atgtgcaaag agaaccgtga gagcctggtg gtgaactatg aggacttggc agccagggag    780

cacgtgctgg cctacttcct gcctgaggca ccggcggagc tgctgcagat ctttgatgag    840

gctgccctgg aggtggtact ggccatgtac cccaagtacg accgcatcac caaccacatc    900

catgtccgca tctcccacct gcctctggtg gaggagctgc gctcgctgag gcagctgcat    960

ctgaaccagc tgatccgcac cagtggggtg gtgaccagct gcactggcgt cctgccccag   1020

ctcagcatgg tcaagtacaa ctgcaacaag tgcaatttcg tcctgggtcc tttctgccag   1080

tcccagaacc aggaggtgaa accaggctcc tgtcctgagt gccagtcggc cggccccttt   1140

gaggtcaaca tggaggagac catctatcag aactaccagc gtatccgaat ccaggagagt   1200

ccaggcaaag tggcggctgg ccggctgccc cgctccaagg acgccattct cctcgcagat   1260

ctggtggaca gctgcaagcc aggagacgag atagagctga ctggcatcta tcacaacaac   1320

tatgatggct ccctcaacac tgccaatggc ttccctgtct ttgccactgt catcctagcc   1380

aaccacgtgg ccaagaagga caacaaggtt gctgtagggg aactgaccga tgaagatgtg   1440

aagatgatca ctagcctctc caaggatcag cagatcggag agaagatctt tgccagcatt   1500

gctccttcca tctatggtca tgaagacatc aagagaggcc tggctctggc cctgttcgga   1560

ggggagccca aaaacccagg tggcaagcac aaggtacgtg gtgatatcaa cgtgctcttg   1620

tgcggagacc ctggcacagc gaagtcgcag tttctcaagt atattgagaa agtgtccagc   1680

cgagccatct tcaccactgg ccagggggcg tcggctgtgg gcctcacggc gtatgtccag   1740

cggcaccctg tcagcaggga gtggaccttg gaggctgggg ccctggttct ggctgaccga   1800

ggagtgtgtc tcattgatga atttgacaag atgaatgacc aggacagaac cagcatccat   1860

gaggccatgg agcaacagag catctccatc tcgaaggctg gcatcgtcac ctccctgcag   1920

gctcgctgca cggtcattgc tgccgccaac cccataggag ggcgctacga cccctcgctg   1980

actttctctg agaacgtgga cctcacagag cccatcatct cacgctttga catcctgtgt   2040

gtggtgaggg acaccgtgga cccagtccag gacgagatgc tggcccgctt cgtggtgggc   2100

agccacgtca gacaccaccc cagcaacaag gaggaggagg ggctggccaa tggcagcgct   2160

gctgagcccg ccatgcccaa cacgtatggc gtggagcccc tgccccagga ggtcctgaag   2220

aagtacatca tctacgccaa ggagagggtc cacccgaagc tcaaccagat ggaccaggac   2280

aaggtggcca agatgtacag tgacctgagg aaagaatcta tggcgacagg cagcatcccc   2340

attacggtgc ggcacatcga gtccatgatc cgcatggcgg aggcccacgc gcgcatccat   2400

ctgcgggact atgtgatcga agacgacgtc aacatggcca tccgcgtgat gctggagagc   2460

ttcatagaca cacagaagtt cagcgtcatg cgcagcatgc gcaagacttt tgcccgctac   2520

ctttcattcc ggcgtgacaa caatgagctg ttgctcttca tactgaagca gttagtggca   2580

gagcaggtga catatcagcg caaccgcttt ggggcccagc aggacactat tgaggtccct   2640

gagaaggact tggtggataa ggctcgtcag atcaacatcc acaacctctc tgcattttat   2700

gacagtgagc tcttcaggat gaacaagttc agccacgacc tgaaaaggaa aatgatcctg   2760

cagcagttct gaggccctat gccatccata aggattcctt gggattctgg tttggggtgg   2820

tcagtgccct ctgtgcttta tggacacaaa accagagcac ttgatgaact cggggtacta   2880

gggtcagggc ttatagcagg atgtctggct gcacctggca tgactgtttg tttctccaag   2940

cctgctttgt gcttctcacc tttgggtggg atgccttgcc agtgtgtctt acttggttgc   3000

tgaacatctt gccacctccg agtgctttgt ctccactcag taccttggat cagagctgct   3060

gagttcagga tgcctgcgtg tggtttaggt gttagccttc ttacatggat gtcaggagag   3120

ctgctgccct cttggcgtga gttgcgtatt caggctgctt ttgctgcctt tggccagaga   3180

gctggttgaa gatgtttgta atcgttttca gtctcctgca ggtttctgtg cccctgtggt   3240

ggaagagggc acgacagtgc cagcgcagcg ttctgggctc ctcagtcgca ggggtgggat   3300

gtgagtcatg cggattatcc actcgccaca gttatcagct gccattgctc cctgtctgtt   3360

tccccactct cttatttgtg cattcggttt ggtttctgta gttttaattt ttaataaagt   3420

tgaataaaat ataaaaaaaa aaaaaaaaaa aaa                                3453


<210>  836
<211>  904
<212>  PRT
<213>  Homosapiens

<400>  836

Met Ala Glu Ser Ser Glu Ser Phe Thr Met Ala Ser Ser Pro Ala Gln 
1               5                   10                  15      


Arg Arg Arg Gly Asn Asp Pro Leu Thr Ser Ser Pro Gly Arg Ser Ser 
            20                  25                  30          


Arg Arg Thr Asp Ala Leu Thr Ser Ser Pro Gly Arg Asp Leu Pro Pro 
        35                  40                  45              


Phe Glu Asp Glu Ser Glu Gly Leu Leu Gly Thr Glu Gly Pro Leu Glu 
    50                  55                  60                  


Glu Glu Glu Asp Gly Glu Glu Leu Ile Gly Asp Gly Met Glu Arg Asp 
65                  70                  75                  80  


Tyr Arg Ala Ile Pro Glu Leu Asp Ala Tyr Glu Ala Glu Gly Leu Ala 
                85                  90                  95      


Leu Asp Asp Glu Asp Val Glu Glu Leu Thr Ala Ser Gln Arg Glu Ala 
            100                 105                 110         


Ala Glu Arg Ala Met Arg Gln Arg Asp Arg Glu Ala Gly Arg Gly Leu 
        115                 120                 125             


Gly Arg Met Arg Arg Gly Leu Leu Tyr Asp Ser Asp Glu Glu Asp Glu 
    130                 135                 140                 


Glu Arg Pro Ala Arg Lys Arg Arg Gln Val Glu Arg Ala Thr Glu Asp 
145                 150                 155                 160 


Gly Glu Glu Asp Glu Glu Met Ile Glu Ser Ile Glu Asn Leu Glu Asp 
                165                 170                 175     


Leu Lys Gly His Ser Val Arg Glu Trp Val Ser Met Ala Gly Pro Arg 
            180                 185                 190         


Leu Glu Ile His His Arg Phe Lys Asn Phe Leu Arg Thr His Val Asp 
        195                 200                 205             


Ser His Gly His Asn Val Phe Lys Glu Arg Ile Ser Asp Met Cys Lys 
    210                 215                 220                 


Glu Asn Arg Glu Ser Leu Val Val Asn Tyr Glu Asp Leu Ala Ala Arg 
225                 230                 235                 240 


Glu His Val Leu Ala Tyr Phe Leu Pro Glu Ala Pro Ala Glu Leu Leu 
                245                 250                 255     


Gln Ile Phe Asp Glu Ala Ala Leu Glu Val Val Leu Ala Met Tyr Pro 
            260                 265                 270         


Lys Tyr Asp Arg Ile Thr Asn His Ile His Val Arg Ile Ser His Leu 
        275                 280                 285             


Pro Leu Val Glu Glu Leu Arg Ser Leu Arg Gln Leu His Leu Asn Gln 
    290                 295                 300                 


Leu Ile Arg Thr Ser Gly Val Val Thr Ser Cys Thr Gly Val Leu Pro 
305                 310                 315                 320 


Gln Leu Ser Met Val Lys Tyr Asn Cys Asn Lys Cys Asn Phe Val Leu 
                325                 330                 335     


Gly Pro Phe Cys Gln Ser Gln Asn Gln Glu Val Lys Pro Gly Ser Cys 
            340                 345                 350         


Pro Glu Cys Gln Ser Ala Gly Pro Phe Glu Val Asn Met Glu Glu Thr 
        355                 360                 365             


Ile Tyr Gln Asn Tyr Gln Arg Ile Arg Ile Gln Glu Ser Pro Gly Lys 
    370                 375                 380                 


Val Ala Ala Gly Arg Leu Pro Arg Ser Lys Asp Ala Ile Leu Leu Ala 
385                 390                 395                 400 


Asp Leu Val Asp Ser Cys Lys Pro Gly Asp Glu Ile Glu Leu Thr Gly 
                405                 410                 415     


Ile Tyr His Asn Asn Tyr Asp Gly Ser Leu Asn Thr Ala Asn Gly Phe 
            420                 425                 430         


Pro Val Phe Ala Thr Val Ile Leu Ala Asn His Val Ala Lys Lys Asp 
        435                 440                 445             


Asn Lys Val Ala Val Gly Glu Leu Thr Asp Glu Asp Val Lys Met Ile 
    450                 455                 460                 


Thr Ser Leu Ser Lys Asp Gln Gln Ile Gly Glu Lys Ile Phe Ala Ser 
465                 470                 475                 480 


Ile Ala Pro Ser Ile Tyr Gly His Glu Asp Ile Lys Arg Gly Leu Ala 
                485                 490                 495     


Leu Ala Leu Phe Gly Gly Glu Pro Lys Asn Pro Gly Gly Lys His Lys 
            500                 505                 510         


Val Arg Gly Asp Ile Asn Val Leu Leu Cys Gly Asp Pro Gly Thr Ala 
        515                 520                 525             


Lys Ser Gln Phe Leu Lys Tyr Ile Glu Lys Val Ser Ser Arg Ala Ile 
    530                 535                 540                 


Phe Thr Thr Gly Gln Gly Ala Ser Ala Val Gly Leu Thr Ala Tyr Val 
545                 550                 555                 560 


Gln Arg His Pro Val Ser Arg Glu Trp Thr Leu Glu Ala Gly Ala Leu 
                565                 570                 575     


Val Leu Ala Asp Arg Gly Val Cys Leu Ile Asp Glu Phe Asp Lys Met 
            580                 585                 590         


Asn Asp Gln Asp Arg Thr Ser Ile His Glu Ala Met Glu Gln Gln Ser 
        595                 600                 605             


Ile Ser Ile Ser Lys Ala Gly Ile Val Thr Ser Leu Gln Ala Arg Cys 
    610                 615                 620                 


Thr Val Ile Ala Ala Ala Asn Pro Ile Gly Gly Arg Tyr Asp Pro Ser 
625                 630                 635                 640 


Leu Thr Phe Ser Glu Asn Val Asp Leu Thr Glu Pro Ile Ile Ser Arg 
                645                 650                 655     


Phe Asp Ile Leu Cys Val Val Arg Asp Thr Val Asp Pro Val Gln Asp 
            660                 665                 670         


Glu Met Leu Ala Arg Phe Val Val Gly Ser His Val Arg His His Pro 
        675                 680                 685             


Ser Asn Lys Glu Glu Glu Gly Leu Ala Asn Gly Ser Ala Ala Glu Pro 
    690                 695                 700                 


Ala Met Pro Asn Thr Tyr Gly Val Glu Pro Leu Pro Gln Glu Val Leu 
705                 710                 715                 720 


Lys Lys Tyr Ile Ile Tyr Ala Lys Glu Arg Val His Pro Lys Leu Asn 
                725                 730                 735     


Gln Met Asp Gln Asp Lys Val Ala Lys Met Tyr Ser Asp Leu Arg Lys 
            740                 745                 750         


Glu Ser Met Ala Thr Gly Ser Ile Pro Ile Thr Val Arg His Ile Glu 
        755                 760                 765             


Ser Met Ile Arg Met Ala Glu Ala His Ala Arg Ile His Leu Arg Asp 
    770                 775                 780                 


Tyr Val Ile Glu Asp Asp Val Asn Met Ala Ile Arg Val Met Leu Glu 
785                 790                 795                 800 


Ser Phe Ile Asp Thr Gln Lys Phe Ser Val Met Arg Ser Met Arg Lys 
                805                 810                 815     


Thr Phe Ala Arg Tyr Leu Ser Phe Arg Arg Asp Asn Asn Glu Leu Leu 
            820                 825                 830         


Leu Phe Ile Leu Lys Gln Leu Val Ala Glu Gln Val Thr Tyr Gln Arg 
        835                 840                 845             


Asn Arg Phe Gly Ala Gln Gln Asp Thr Ile Glu Val Pro Glu Lys Asp 
    850                 855                 860                 


Leu Val Asp Lys Ala Arg Gln Ile Asn Ile His Asn Leu Ser Ala Phe 
865                 870                 875                 880 


Tyr Asp Ser Glu Leu Phe Arg Met Asn Lys Phe Ser His Asp Leu Lys 
                885                 890                 895     


Arg Lys Met Ile Leu Gln Gln Phe 
            900                 


<210>  837
<211>  2269
<212>  DNA
<213>  Homosapiens

<400>  837
ccagttccgg cacgaggacc atgggccggc tgctgcgggc cgcccggctg ccgccgctgc     60

tttcgccgct gctgcttctg ctggttgggg gagcgttcct gggtgcctgt gtggctgggt    120

ctgatgagcc tggcccagag ggcctcacct ccacctccct gctagacctc ctgctgccca    180

ctggcttgga gccactggac tcagaggagc ctagtgagac catgggcctg ggagctgggc    240

tgggagcccc tggctcaggc ttccccagcg aagagaatga agagtctcgg attctgcagc    300

caccacagta cttctgggaa gaggaggaag agctgaatga ctcaagtctg gacctgggac    360

ccactgcaga ttatgttttt cctgacttaa ctgagaaggc aggttccatt gaagacacta    420

gccaggctca agagctgcca aacctcccct ctcccttgcc caagatgaat ctggttgagc    480

ctccctggca tatgcctccc agagaggagg aagaagagga agaggaagag gaggagaggg    540

agaaggaaga ggtagagaaa caagaggagg aggaagagga ggagctgctc cctgtgaatg    600

gatcccaaga agaagccaag cctcaggtcc gtgacttttc tctcaccagc agcagccaga    660

ccccaggggc caccaaaagc aggcatgaag actccgggga ccaggcctca tcaggtgtgg    720

aggtggagag cagcatgggg cccagcttgc tgctgccttc agtcacccca actacagtga    780

ctccggggga ccaggactcc accagccaag aggcagaggc cacagtgctg ccagctgcag    840

ggcttggggt agagttcgag gctcctcagg aagcaagcga ggaagccact gcaggagcag    900

ctggtttgtc tggccagcac gaggaggtgc cggccttgcc ttcattccct caaaccacag    960

ctcccagtgg ggccgagcac ccagatgaag atccccttgg ctctagaacc tcagcctctt   1020

ccccactggc ccctggagac atggaactga caccttcctc tgctaccttg ggacaagaag   1080

atctcaacca gcagctccta gaagggcagg cagctgaagc tcaatccagg ataccctggg   1140

attctacgca ggtgatctgc aaggactgga gcaatctggc tgggaaaaac tacatcattc   1200

tgaacatgac agagaacata gactgtgagg tgttccggca gcaccggggg ccacagctcc   1260

tggccctggt ggaagaggtg ctgccccgcc atggcagtgg ccaccatggg gcctggcaca   1320

tctctctgag caagcccagc gagaaggagc agcaccttct catgacactg gtgggcgagc   1380

agggggtggt gcccactcaa gatgtccttt ccatgctggg tgacatccgc aggagcctgg   1440

aggagattgg catccagaac tattccacaa ccagcagctg ccaggcgcgg gccagccagg   1500

tgcgcagcga ctacggcacg ctcttcgtgg tgctggtggt cattggggcc atctgcatca   1560

tcatcattgc gcttggcctg ctctacaact gctggcagcg ccggctgccc aagctcaagc   1620

acgtgtcgca cggcgaggag ctgcgcttcg tggagaacgg ctgccacgac aaccccacgc   1680

tggacgtggc cagcgacagc cagtcggaga tgcaggagaa gcaccccagc ctgaacggcg   1740

gcggggccct caacggcccg gggagctggg gggcgctcat ggggggcaag cgggaccccg   1800

aggactcgga cgtgttcgag gaggacacgc acctgtgagc gcagcgaggc gcaggccgag   1860

tgggccgcca ggaccaagcg aggtggaccc cgaaacggac ggcccggagc ccgcaccagc   1920

cccgcgccta cccggccgcc cccgcgcctg gccctcggcg cgggctcctt cccgcttccc   1980

ccgacttcac acggcggctt cggaccaact ccctcactcc cgcccgaggg gcaggcctca   2040

aagcccgcct tggccccgct ttcccgcccc tgaaccccgg ccccgcgggc ggcgggcgcg   2100

cttcctgcgc cccgggactc aattaaaccc gcccggagac cacgcgggcc cagcgaaaaa   2160

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa               2269


<210>  838
<211>  605
<212>  PRT
<213>  Homosapiens

<400>  838

Met Gly Arg Leu Leu Arg Ala Ala Arg Leu Pro Pro Leu Leu Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Val Gly Gly Ala Phe Leu Gly Ala Cys Val Ala 
            20                  25                  30          


Gly Ser Asp Glu Pro Gly Pro Glu Gly Leu Thr Ser Thr Ser Leu Leu 
        35                  40                  45              


Asp Leu Leu Leu Pro Thr Gly Leu Glu Pro Leu Asp Ser Glu Glu Pro 
    50                  55                  60                  


Ser Glu Thr Met Gly Leu Gly Ala Gly Leu Gly Ala Pro Gly Ser Gly 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Asn Glu Glu Ser Arg Ile Leu Gln Pro Pro Gln 
                85                  90                  95      


Tyr Phe Trp Glu Glu Glu Glu Glu Leu Asn Asp Ser Ser Leu Asp Leu 
            100                 105                 110         


Gly Pro Thr Ala Asp Tyr Val Phe Pro Asp Leu Thr Glu Lys Ala Gly 
        115                 120                 125             


Ser Ile Glu Asp Thr Ser Gln Ala Gln Glu Leu Pro Asn Leu Pro Ser 
    130                 135                 140                 


Pro Leu Pro Lys Met Asn Leu Val Glu Pro Pro Trp His Met Pro Pro 
145                 150                 155                 160 


Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Arg Glu Lys Glu 
                165                 170                 175     


Glu Val Glu Lys Gln Glu Glu Glu Glu Glu Glu Glu Leu Leu Pro Val 
            180                 185                 190         


Asn Gly Ser Gln Glu Glu Ala Lys Pro Gln Val Arg Asp Phe Ser Leu 
        195                 200                 205             


Thr Ser Ser Ser Gln Thr Pro Gly Ala Thr Lys Ser Arg His Glu Asp 
    210                 215                 220                 


Ser Gly Asp Gln Ala Ser Ser Gly Val Glu Val Glu Ser Ser Met Gly 
225                 230                 235                 240 


Pro Ser Leu Leu Leu Pro Ser Val Thr Pro Thr Thr Val Thr Pro Gly 
                245                 250                 255     


Asp Gln Asp Ser Thr Ser Gln Glu Ala Glu Ala Thr Val Leu Pro Ala 
            260                 265                 270         


Ala Gly Leu Gly Val Glu Phe Glu Ala Pro Gln Glu Ala Ser Glu Glu 
        275                 280                 285             


Ala Thr Ala Gly Ala Ala Gly Leu Ser Gly Gln His Glu Glu Val Pro 
    290                 295                 300                 


Ala Leu Pro Ser Phe Pro Gln Thr Thr Ala Pro Ser Gly Ala Glu His 
305                 310                 315                 320 


Pro Asp Glu Asp Pro Leu Gly Ser Arg Thr Ser Ala Ser Ser Pro Leu 
                325                 330                 335     


Ala Pro Gly Asp Met Glu Leu Thr Pro Ser Ser Ala Thr Leu Gly Gln 
            340                 345                 350         


Glu Asp Leu Asn Gln Gln Leu Leu Glu Gly Gln Ala Ala Glu Ala Gln 
        355                 360                 365             


Ser Arg Ile Pro Trp Asp Ser Thr Gln Val Ile Cys Lys Asp Trp Ser 
    370                 375                 380                 


Asn Leu Ala Gly Lys Asn Tyr Ile Ile Leu Asn Met Thr Glu Asn Ile 
385                 390                 395                 400 


Asp Cys Glu Val Phe Arg Gln His Arg Gly Pro Gln Leu Leu Ala Leu 
                405                 410                 415     


Val Glu Glu Val Leu Pro Arg His Gly Ser Gly His His Gly Ala Trp 
            420                 425                 430         


His Ile Ser Leu Ser Lys Pro Ser Glu Lys Glu Gln His Leu Leu Met 
        435                 440                 445             


Thr Leu Val Gly Glu Gln Gly Val Val Pro Thr Gln Asp Val Leu Ser 
    450                 455                 460                 


Met Leu Gly Asp Ile Arg Arg Ser Leu Glu Glu Ile Gly Ile Gln Asn 
465                 470                 475                 480 


Tyr Ser Thr Thr Ser Ser Cys Gln Ala Arg Ala Ser Gln Val Arg Ser 
                485                 490                 495     


Asp Tyr Gly Thr Leu Phe Val Val Leu Val Val Ile Gly Ala Ile Cys 
            500                 505                 510         


Ile Ile Ile Ile Ala Leu Gly Leu Leu Tyr Asn Cys Trp Gln Arg Arg 
        515                 520                 525             


Leu Pro Lys Leu Lys His Val Ser His Gly Glu Glu Leu Arg Phe Val 
    530                 535                 540                 


Glu Asn Gly Cys His Asp Asn Pro Thr Leu Asp Val Ala Ser Asp Ser 
545                 550                 555                 560 


Gln Ser Glu Met Gln Glu Lys His Pro Ser Leu Asn Gly Gly Gly Ala 
                565                 570                 575     


Leu Asn Gly Pro Gly Ser Trp Gly Ala Leu Met Gly Gly Lys Arg Asp 
            580                 585                 590         


Pro Glu Asp Ser Asp Val Phe Glu Glu Asp Thr His Leu 
        595                 600                 605 


<210>  839
<211>  2020
<212>  DNA
<213>  Homosapiens

<400>  839
ggcggggcgg ggctgagcgt gtttacatcc gccgggtgcg cggcttcgcc gcccgaggtc     60

gttcggctcg ggtaccatcc tccgcgccat ggacaccagc gacctgttcg ccagctgcag    120

gaagggggat gtgggccgag tgcgaccatg aacccgtcct gacccaggct ctgacctcct    180

tcctgcccag gtacctgctg gagcagcgag acgtggaggt actatgcctg cttgtgtggg    240

cacgaggagc tggtactcta ccttctggcc aatggagccc gctgcgaggc caacaccttc    300

gatggtgagc gctgcctcta tggggcactg agtgacccca tccgccgggc tctacgcgat    360

tacaagcagg tcacggcttc ctgcaggagg cgggattact atgacgactt cttgcagcgg    420

cttctagagc agggcatcca cagtgacgtg gtctttgtag tacacgggaa gccattccgg    480

gtgcatcgct gcgtcctggg tgcacgtagt gcctactttg ccaacatgct ggacaccaaa    540

tggaagggca agagtgtcgt ggttctcagg cacccactga tcaaccccgt ggcctttggg    600

gccctgctgc agtacctgta cacaggccgc ctggacattg gcgtagagca tgtgagtgac    660

tgtgagcgcc tggccaagca atgccagctg tgggacctgc tcagcgacct ggaggccaag    720

tgcgagaagg tgtctgagtt tgtggcgtct aagccaggca cgtgtgtgaa ggtgctgacc    780

atcgagcccc cacctgcaga cccccgcctc cgggaggaca tggcgctgct ggccgattgt    840

gccctgcccc ccgagctccg aggtgatctt tgggagctgc ccttcccttg tcctgacggc    900

ttcaacagct gccctgacat ctgcttccga gtggctggct gcagcttcct ctgccacaag    960

gcctttttct gtggccgcag tgactacttc cgagccctgc tggatgacca cttccgagag   1020

agcgaggagc cagcgacctc agggggcccc ccagccgtca ccctgcatgg catctcaccc   1080

gacgtcttca ctcacgtgct ctactacatg tacagcgacc acactgagct gtcccccgag   1140

gcagcctatg atgtgctgag cgtcgccgac atgtacctgc tgccaggcct gaagaggctg   1200

tgcggccgca gcctggctca gatgctagac gaggacactg tggtgggtgt gtggcgcgtg   1260

gccaagctct tccgcctggc gcggcttgag gaccagtgca ctgagtacat ggccaaggtc   1320

attgagaagc tggtggagcg ggaggacttc gtggaggcgg tgaaggagga ggcagcggct   1380

gtggcagccc ggcaggagac ggactctatc ccgctggtgg acgacatccg cttccacgtg   1440

gccagcacgg tgcagaccta cagcgccata gaggaggcgc agcagcgtct gcgggcactc   1500

gaggacctgc tcgtgtccat cggtctggac tgttgagccc ctggctgggc agccccaggg   1560

gccaggagct ctcttggaga caagcatgtg tatgcgtttg tgtgcagctc ttcttcctgc   1620

tccctgcaca ttgagggctt catggggggt gcgaggggct cagtggggct tctcttccct   1680

ccatgagcct ggagacccca ggggaggatc catttgggat gagccccctc cccccaatgc   1740

acaagccagc ccccaagacc ctgggggtgg acaccactca gggaaacctg gggtgggggt   1800

gggctttggt cttagcactt tccttctcca gatcccccct acccacccca gtcccaaatc   1860

cagtcctctg gcccttgcct agccctgaat tgcttctcta agctggtgtt cccatgcaca   1920

gggccattca ggaagggctg ggggagtgtg tgtggcaata aagcttgaag gcaccgtggg   1980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                         2020


<210>  840
<211>  336
<212>  PRT
<213>  Homosapiens

<400>  840

Met Leu Asp Thr Lys Trp Lys Gly Lys Ser Val Val Val Leu Arg His 
1               5                   10                  15      


Pro Leu Ile Asn Pro Val Ala Phe Gly Ala Leu Leu Gln Tyr Leu Tyr 
            20                  25                  30          


Thr Gly Arg Leu Asp Ile Gly Val Glu His Val Ser Asp Cys Glu Arg 
        35                  40                  45              


Leu Ala Lys Gln Cys Gln Leu Trp Asp Leu Leu Ser Asp Leu Glu Ala 
    50                  55                  60                  


Lys Cys Glu Lys Val Ser Glu Phe Val Ala Ser Lys Pro Gly Thr Cys 
65                  70                  75                  80  


Val Lys Val Leu Thr Ile Glu Pro Pro Pro Ala Asp Pro Arg Leu Arg 
                85                  90                  95      


Glu Asp Met Ala Leu Leu Ala Asp Cys Ala Leu Pro Pro Glu Leu Arg 
            100                 105                 110         


Gly Asp Leu Trp Glu Leu Pro Phe Pro Cys Pro Asp Gly Phe Asn Ser 
        115                 120                 125             


Cys Pro Asp Ile Cys Phe Arg Val Ala Gly Cys Ser Phe Leu Cys His 
    130                 135                 140                 


Lys Ala Phe Phe Cys Gly Arg Ser Asp Tyr Phe Arg Ala Leu Leu Asp 
145                 150                 155                 160 


Asp His Phe Arg Glu Ser Glu Glu Pro Ala Thr Ser Gly Gly Pro Pro 
                165                 170                 175     


Ala Val Thr Leu His Gly Ile Ser Pro Asp Val Phe Thr His Val Leu 
            180                 185                 190         


Tyr Tyr Met Tyr Ser Asp His Thr Glu Leu Ser Pro Glu Ala Ala Tyr 
        195                 200                 205             


Asp Val Leu Ser Val Ala Asp Met Tyr Leu Leu Pro Gly Leu Lys Arg 
    210                 215                 220                 


Leu Cys Gly Arg Ser Leu Ala Gln Met Leu Asp Glu Asp Thr Val Val 
225                 230                 235                 240 


Gly Val Trp Arg Val Ala Lys Leu Phe Arg Leu Ala Arg Leu Glu Asp 
                245                 250                 255     


Gln Cys Thr Glu Tyr Met Ala Lys Val Ile Glu Lys Leu Val Glu Arg 
            260                 265                 270         


Glu Asp Phe Val Glu Ala Val Lys Glu Glu Ala Ala Ala Val Ala Ala 
        275                 280                 285             


Arg Gln Glu Thr Asp Ser Ile Pro Leu Val Asp Asp Ile Arg Phe His 
    290                 295                 300                 


Val Ala Ser Thr Val Gln Thr Tyr Ser Ala Ile Glu Glu Ala Gln Gln 
305                 310                 315                 320 


Arg Leu Arg Ala Leu Glu Asp Leu Leu Val Ser Ile Gly Leu Asp Cys 
                325                 330                 335     


<210>  841
<211>  1989
<212>  DNA
<213>  Homosapiens

<400>  841
ggcggggcgg ggctgagcgt gtttacatcc gccgggtgcg cggcttcgcc gcccgaggtc     60

gttcggctcg ggtaccatcc tccgcgccat ggacaccagc gacctgttcg ccagctgcag    120

gaagggggat gtgggccgag tgcggtacct gctggagcag cgagacgtgg aggtgaatgt    180

gcgggacaag tgggacagca cccccttgta ctatgcctgc ttgtgtgggc acgaggagct    240

ggtactctac cttctggcca atggagcccg ctgcgaggcc aacaccttcg atggtgagcg    300

ctgcctctat ggggcactga gtgaccccat ccgccgggct ctacgcgatt acaagcaggt    360

cacggcttcc tgcaggaggc gggattacta tgacgacttc ttgcagcggc ttctagagca    420

gggcatccac agtgacgtgg tctttgtagt acacgggaag ccattccggg tgcatcgctg    480

cgtcctgggt gcacgtagtg cctactttgc caacatgctg gacaccaaat ggaagggcaa    540

gagtgtcgtg gttctcaggc acccactgat caaccccgtg gcctttgggg ccctgctgca    600

gtacctgtac acaggccgcc tggacattgg cgtagagcat gtgagtgact gtgagcgcct    660

ggccaagcaa tgccagctgt gggacctgct cagcgacctg gaggccaagt gcgagaaggt    720

gtctgagttt gtggcgtcta agccaggcac gtgtgtgaag gtgctgacca tcgagccccc    780

acctgcagac ccccgcctcc gggaggacat ggcgctgctg gccgattgtg ccctgccccc    840

cgagctccga ggtgatcttt gggagctgcc cttcccttgt cctgacggct tcaacagctg    900

ccctgacatc tgcttccgag tggctggctg cagcttcctc tgccacaagg cctttttctg    960

tggccgcagt gactacttcc gagccctgct ggatgaccac ttccgagaga gcgaggagcc   1020

agcgacctca gggggccccc cagccgtcac cctgcatggc atctcacccg acgtcttcac   1080

tcacgtgctc tactacatgt acagcgacca cactgagctg tcccccgagg cagcctatga   1140

tgtgctgagc gtcgccgaca tgtacctgct gccaggcctg aagaggctgt gcggccgcag   1200

cctggctcag atgctagacg aggacactgt ggtgggtgtg tggcgcgtgg ccaagctctt   1260

ccgcctggcg cggcttgagg accagtgcac tgagtacatg gccaaggtca ttgagaagct   1320

ggtggagcgg gaggacttcg tggaggcggt gaaggaggag gcagcggctg tggcagcccg   1380

gcaggagacg gactctatcc cgctggtgga cgacatccgc ttccacgtgg ccagcacggt   1440

gcagacctac agcgccatag aggaggcgca gcagcgtctg cgggcactcg aggacctgct   1500

cgtgtccatc ggtctggact gttgagcccc tggctgggca gccccagggg ccaggagctc   1560

tcttggagac aagcatgtgt atgcgtttgt gtgcagctct tcttcctgct ccctgcacat   1620

tgagggcttc atggggggtg cgaggggctc agtggggctt ctcttccctc catgagcctg   1680

gagaccccag gggaggatcc atttgggatg agccccctcc ccccaatgca caagccagcc   1740

cccaagaccc tgggggtgga caccactcag ggaaacctgg ggtgggggtg ggctttggtc   1800

ttagcacttt ccttctccag atccccccta cccaccccag tcccaaatcc agtcctctgg   1860

cccttgccta gccctgaatt gcttctctaa gctggtgttc ccatgcacag ggccattcag   1920

gaagggctgg gggagtgtgt gtggcaataa agcttgaagg caccgtggga aaaaaaaaaa   1980

aaaaaaaaa                                                           1989


<210>  842
<211>  478
<212>  PRT
<213>  Homosapiens

<400>  842

Met Asp Thr Ser Asp Leu Phe Ala Ser Cys Arg Lys Gly Asp Val Gly 
1               5                   10                  15      


Arg Val Arg Tyr Leu Leu Glu Gln Arg Asp Val Glu Val Asn Val Arg 
            20                  25                  30          


Asp Lys Trp Asp Ser Thr Pro Leu Tyr Tyr Ala Cys Leu Cys Gly His 
        35                  40                  45              


Glu Glu Leu Val Leu Tyr Leu Leu Ala Asn Gly Ala Arg Cys Glu Ala 
    50                  55                  60                  


Asn Thr Phe Asp Gly Glu Arg Cys Leu Tyr Gly Ala Leu Ser Asp Pro 
65                  70                  75                  80  


Ile Arg Arg Ala Leu Arg Asp Tyr Lys Gln Val Thr Ala Ser Cys Arg 
                85                  90                  95      


Arg Arg Asp Tyr Tyr Asp Asp Phe Leu Gln Arg Leu Leu Glu Gln Gly 
            100                 105                 110         


Ile His Ser Asp Val Val Phe Val Val His Gly Lys Pro Phe Arg Val 
        115                 120                 125             


His Arg Cys Val Leu Gly Ala Arg Ser Ala Tyr Phe Ala Asn Met Leu 
    130                 135                 140                 


Asp Thr Lys Trp Lys Gly Lys Ser Val Val Val Leu Arg His Pro Leu 
145                 150                 155                 160 


Ile Asn Pro Val Ala Phe Gly Ala Leu Leu Gln Tyr Leu Tyr Thr Gly 
                165                 170                 175     


Arg Leu Asp Ile Gly Val Glu His Val Ser Asp Cys Glu Arg Leu Ala 
            180                 185                 190         


Lys Gln Cys Gln Leu Trp Asp Leu Leu Ser Asp Leu Glu Ala Lys Cys 
        195                 200                 205             


Glu Lys Val Ser Glu Phe Val Ala Ser Lys Pro Gly Thr Cys Val Lys 
    210                 215                 220                 


Val Leu Thr Ile Glu Pro Pro Pro Ala Asp Pro Arg Leu Arg Glu Asp 
225                 230                 235                 240 


Met Ala Leu Leu Ala Asp Cys Ala Leu Pro Pro Glu Leu Arg Gly Asp 
                245                 250                 255     


Leu Trp Glu Leu Pro Phe Pro Cys Pro Asp Gly Phe Asn Ser Cys Pro 
            260                 265                 270         


Asp Ile Cys Phe Arg Val Ala Gly Cys Ser Phe Leu Cys His Lys Ala 
        275                 280                 285             


Phe Phe Cys Gly Arg Ser Asp Tyr Phe Arg Ala Leu Leu Asp Asp His 
    290                 295                 300                 


Phe Arg Glu Ser Glu Glu Pro Ala Thr Ser Gly Gly Pro Pro Ala Val 
305                 310                 315                 320 


Thr Leu His Gly Ile Ser Pro Asp Val Phe Thr His Val Leu Tyr Tyr 
                325                 330                 335     


Met Tyr Ser Asp His Thr Glu Leu Ser Pro Glu Ala Ala Tyr Asp Val 
            340                 345                 350         


Leu Ser Val Ala Asp Met Tyr Leu Leu Pro Gly Leu Lys Arg Leu Cys 
        355                 360                 365             


Gly Arg Ser Leu Ala Gln Met Leu Asp Glu Asp Thr Val Val Gly Val 
    370                 375                 380                 


Trp Arg Val Ala Lys Leu Phe Arg Leu Ala Arg Leu Glu Asp Gln Cys 
385                 390                 395                 400 


Thr Glu Tyr Met Ala Lys Val Ile Glu Lys Leu Val Glu Arg Glu Asp 
                405                 410                 415     


Phe Val Glu Ala Val Lys Glu Glu Ala Ala Ala Val Ala Ala Arg Gln 
            420                 425                 430         


Glu Thr Asp Ser Ile Pro Leu Val Asp Asp Ile Arg Phe His Val Ala 
        435                 440                 445             


Ser Thr Val Gln Thr Tyr Ser Ala Ile Glu Glu Ala Gln Gln Arg Leu 
    450                 455                 460                 


Arg Ala Leu Glu Asp Leu Leu Val Ser Ile Gly Leu Asp Cys 
465                 470                 475             


<210>  843
<211>  1974
<212>  DNA
<213>  Homosapiens

<400>  843
ggcggggcgg ggctgagcgt gtttacatcc gccgggtgcg cggcttcgcc gcccgaggtc     60

gttcggctcg ggtaccatcc tccgcgccat ggacaccagc gacctgttcg ccagctgcag    120

gaagggggat gtgggccgag tgcggtacct gctggagcag cgagacgtgg aggtactatg    180

cctgcttgtg tgggcacgag gagctggtac tctaccttct ggccaatgga gcccgctgcg    240

aggccaacac cttcgatggt gagcgctgcc tctatggggc actgagtgac cccatccgcc    300

gggctctacg cgattacaag caggtcacgg cttcctgcag gaggcgggat tactatgacg    360

acttcttgca gcggcttcta gagcagggca tccacagtga cgtggtcttt gtagtacacg    420

ggaagccatt ccgggtgcat cgctgcgtcc tgggtgcacg tagtgcctac tttgccaaca    480

tgctggacac caaatggaag ggcaagagtg tcgtggttct caggcaccca ctgatcaacc    540

ccgtggcctt tggggccctg ctgcagtacc tgtacacagg ccgcctggac attggcgtag    600

agcatgtgag tgactgtgag cgcctggcca agcaatgcca gctgtgggac ctgctcagcg    660

acctggaggc caagtgcgag aaggtgtctg agtttgtggc gtctaagcca ggcacgtgtg    720

tgaaggtgct gaccatcgag cccccacctg cagacccccg cctccgggag gacatggcgc    780

tgctggccga ttgtgccctg ccccccgagc tccgaggtga tctttgggag ctgcccttcc    840

cttgtcctga cggcttcaac agctgccctg acatctgctt ccgagtggct ggctgcagct    900

tcctctgcca caaggccttt ttctgtggcc gcagtgacta cttccgagcc ctgctggatg    960

accacttccg agagagcgag gagccagcga cctcaggggg ccccccagcc gtcaccctgc   1020

atggcatctc acccgacgtc ttcactcacg tgctctacta catgtacagc gaccacactg   1080

agctgtcccc cgaggcagcc tatgatgtgc tgagcgtcgc cgacatgtac ctgctgccag   1140

gcctgaagag gctgtgcggc cgcagcctgg ctcagatgct agacgaggac actgtggtgg   1200

gtgtgtggcg cgtggccaag ctcttccgcc tggcgcggct tgaggaccag tgcactgagt   1260

acatggccaa ggtcattgag aagctggtgg agcgggagga cttcgtggag gcggtgaagg   1320

aggaggcagc ggctgtggca gcccggcagg agacggactc tatcccgctg gtggacgaca   1380

tccgcttcca cgtggccagc acggtgcaga cctacagcgc catagaggag gcgcagcagc   1440

gtctgcgggc actcgaggac ctgctcgtgt ccatcggtct ggactgttga gcccctggct   1500

gggcagcccc aggggccagg agctctcttg gagacaagca tgtgtatgcg tttgtgtgca   1560

gctcttcttc ctgctccctg cacattgagg gcttcatggg gggtgcgagg ggctcagtgg   1620

ggcttctctt ccctccatga gcctggagac cccaggggag gatccatttg ggatgagccc   1680

cctcccccca atgcacaagc cagcccccaa gaccctgggg gtggacacca ctcagggaaa   1740

cctggggtgg gggtgggctt tggtcttagc actttccttc tccagatccc ccctacccac   1800

cccagtccca aatccagtcc tctggccctt gcctagccct gaattgcttc tctaagctgg   1860

tgttcccatg cacagggcca ttcaggaagg gctgggggag tgtgtgtggc aataaagctt   1920

gaaggcaccg tgggaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa         1974


<210>  844
<211>  453
<212>  PRT
<213>  Homosapiens

<400>  844

Met Trp Ala Glu Cys Gly Thr Cys Trp Ser Ser Glu Thr Trp Arg Tyr 
1               5                   10                  15      


Tyr Ala Cys Leu Cys Gly His Glu Glu Leu Val Leu Tyr Leu Leu Ala 
            20                  25                  30          


Asn Gly Ala Arg Cys Glu Ala Asn Thr Phe Asp Gly Glu Arg Cys Leu 
        35                  40                  45              


Tyr Gly Ala Leu Ser Asp Pro Ile Arg Arg Ala Leu Arg Asp Tyr Lys 
    50                  55                  60                  


Gln Val Thr Ala Ser Cys Arg Arg Arg Asp Tyr Tyr Asp Asp Phe Leu 
65                  70                  75                  80  


Gln Arg Leu Leu Glu Gln Gly Ile His Ser Asp Val Val Phe Val Val 
                85                  90                  95      


His Gly Lys Pro Phe Arg Val His Arg Cys Val Leu Gly Ala Arg Ser 
            100                 105                 110         


Ala Tyr Phe Ala Asn Met Leu Asp Thr Lys Trp Lys Gly Lys Ser Val 
        115                 120                 125             


Val Val Leu Arg His Pro Leu Ile Asn Pro Val Ala Phe Gly Ala Leu 
    130                 135                 140                 


Leu Gln Tyr Leu Tyr Thr Gly Arg Leu Asp Ile Gly Val Glu His Val 
145                 150                 155                 160 


Ser Asp Cys Glu Arg Leu Ala Lys Gln Cys Gln Leu Trp Asp Leu Leu 
                165                 170                 175     


Ser Asp Leu Glu Ala Lys Cys Glu Lys Val Ser Glu Phe Val Ala Ser 
            180                 185                 190         


Lys Pro Gly Thr Cys Val Lys Val Leu Thr Ile Glu Pro Pro Pro Ala 
        195                 200                 205             


Asp Pro Arg Leu Arg Glu Asp Met Ala Leu Leu Ala Asp Cys Ala Leu 
    210                 215                 220                 


Pro Pro Glu Leu Arg Gly Asp Leu Trp Glu Leu Pro Phe Pro Cys Pro 
225                 230                 235                 240 


Asp Gly Phe Asn Ser Cys Pro Asp Ile Cys Phe Arg Val Ala Gly Cys 
                245                 250                 255     


Ser Phe Leu Cys His Lys Ala Phe Phe Cys Gly Arg Ser Asp Tyr Phe 
            260                 265                 270         


Arg Ala Leu Leu Asp Asp His Phe Arg Glu Ser Glu Glu Pro Ala Thr 
        275                 280                 285             


Ser Gly Gly Pro Pro Ala Val Thr Leu His Gly Ile Ser Pro Asp Val 
    290                 295                 300                 


Phe Thr His Val Leu Tyr Tyr Met Tyr Ser Asp His Thr Glu Leu Ser 
305                 310                 315                 320 


Pro Glu Ala Ala Tyr Asp Val Leu Ser Val Ala Asp Met Tyr Leu Leu 
                325                 330                 335     


Pro Gly Leu Lys Arg Leu Cys Gly Arg Ser Leu Ala Gln Met Leu Asp 
            340                 345                 350         


Glu Asp Thr Val Val Gly Val Trp Arg Val Ala Lys Leu Phe Arg Leu 
        355                 360                 365             


Ala Arg Leu Glu Asp Gln Cys Thr Glu Tyr Met Ala Lys Val Ile Glu 
    370                 375                 380                 


Lys Leu Val Glu Arg Glu Asp Phe Val Glu Ala Val Lys Glu Glu Ala 
385                 390                 395                 400 


Ala Ala Val Ala Ala Arg Gln Glu Thr Asp Ser Ile Pro Leu Val Asp 
                405                 410                 415     


Asp Ile Arg Phe His Val Ala Ser Thr Val Gln Thr Tyr Ser Ala Ile 
            420                 425                 430         


Glu Glu Ala Gln Gln Arg Leu Arg Ala Leu Glu Asp Leu Leu Val Ser 
        435                 440                 445             


Ile Gly Leu Asp Cys 
    450             


<210>  845
<211>  4192
<212>  DNA
<213>  Homosapiens

<400>  845
tggcggcgca gacgccgcac cctgtcgccg cgaagccggt cgcgcgcagc tcgtcccggc     60

cctggcccgc cgcaaacgag gatccgctgc gctcggggaa cgcgacagcg gcgctcgtgg    120

ccccggacct gaagaccctt ccagcatgcc agaggaaagt tcccccaggc ggaccccgca    180

gagcattccc taccaggacc tccctcacct ggtcaatgca gacggacagt acctcttctg    240

caggtactgg aaacccacag gcacacccaa ggccctcatc tttgtgtccc atggagccgg    300

agagcacagt ggccgctatg aagagctggc tcggatgctg atggggctgg acctgctggt    360

gttcgcccac gaccatgttg gccacggaca gagcgaaggg gagaggatgg tagtgtctga    420

cttccacgtt ttcgtcaggg atgtgttgca gcatgtggat tccatgcaga aagactaccc    480

tgggcttcct gtcttccttc tgggccactc catgggaggc gccatcgcca tcctcacggc    540

cgcagagagg ccgggccact tcgccggcat ggtactcatt tcgcctctgg ttcttgccaa    600

tcctgaatct gcaacaactt tcaaggtcct tgctgcgaaa gtgctcaacc ttgtgctgcc    660

aaacttgtcc ctcgggccca tcgactccag cgtgctctct cggaataaga cagaggtcga    720

catttataac tcagaccccc tgatctgccg ggcagggctg aaggtgtgct tcggcatcca    780

actgctgaat gccgtctcac gggtggagcg cgccctcccc aagctgactg tgcccttcct    840

gctgctccag ggctctgccg atcgcctatg tgacagcaaa ggggcctacc tgctcatgga    900

gttagccaag agccaggaca agactctcaa gatttatgaa ggtgcctacc atgttctcca    960

caaggagctt cctgaagtca ccaactccgt cttccatgaa ataaacatgt gggtctctca   1020

aaggacagcc acggcaggaa ctgcgtcccc accctgaatg cattggccgg tgcccggctc   1080

atggtctggg ggatgcaggc aggggaaggg cagagatggc ttctcagata tggcttgcca   1140

aaaaaaaaaa aaaaaaaaaa tcagaaattg gagaaatcct tagcacaatt ttctaaaaaa   1200

taacagacat ttttgttata cattagacta tcagacactg gacctacctt aatggttaga   1260

cactttatgc aaaaaaagag aaaggtccca ggtgattttc cacaaagaat gtgctaaaat   1320

gtccactgaa aacaaagcca agcctctgcc ctgcctctcc cagctcccac aagggttcca   1380

ggaattcctg gtgttcccag gacaccagac tgcaataact ggaggcgcct ccttcctgcc   1440

cacccttcgc tcacgcccca gcgccctctc tgaccagcct ccgcttggtg gccttcctct   1500

ggccgtgtga tgaggtggtt gctgtctcca taggggccag ctccccaggg cagactcacg   1560

tgcccctctg aggctcagaa aatgcccagc ccttcctcaa aatgagcagc cacccatgac   1620

tttgtgggct ccttgttagc ctgagaccag gctttgcaga ggggcggggg gtgaggctta   1680

gcccagaagg agaactgagc aggaaaccaa ggctcttctc tgtcccctgc ccttcccctc   1740

ctgccagggg gaggctcagg ttggtccccg agtgccgcct gtactcacaa aggctgcctt   1800

tcctctagag tcactaattt tacctgatgc tatgagagaa tcatattgaa gatgaaatgt   1860

ctaatatata atgtatattt taaagcagag actattttgg tggataggtg ggagggagca   1920

aggggagttt gagggaatca gagcttgatg ctactgtaca gaactggaca ggttgggccg   1980

gcagtggtgg ggccagaggg ctctgtgctc taggagctaa gccagcagcc cccgagaggg   2040

gacttggctg ggcctttcct atgggcaagg cccagtgctc ttcctgccca ccagggacca   2100

tggagcagtg gcaccctatg gggctatgat ccctaggcct gggcctgggc ctgcctatgg   2160

cccagagcta ccctgggagt gtcagtgcta gcagcacagc tacctctggt ggcaggagaa   2220

gagaggccca gcacagcagc aggccaggcc ttcctgtcca ggtctgcatg gagcactcgg   2280

tgacccagag cagggactgg aggcaccccc agccctgccc caggccacag caggacaggc   2340

cgggacaggc ctcacccaag gccaaggctg gcatcagcca atcattcaga gctgaggccc   2400

tgggcctagc ctgcccttct caggtgccaa taccacccca gccctgccct tggcctcact   2460

ttttcccagc aataagtggg gttcaccacc cgcctcggga atactttccc cttctaaatg   2520

ggacttgctg ttacctcagg aggctcctta gtgcaaatat gaccctggtc agggctttgc   2580

caccgttgaa gccctgcaga aggtgcaatg taggggttct ggggccacag aggagaggcc   2640

acttcccacc aggaccccca acatgaagtc taggcctcag gggctcccgc ccttcttcct   2700

ccagcagcgg gaactgccac tgctctccca ggccctgttc tggaggctaa ccttggttcc   2760

tggagagtgt gcccctccac cctccctcca gcagccctga tcacaccatg agagccagga   2820

acgggtcacc ctgctgaaga tcactctgtg ccctggggga ggagccaagc cctcacccca   2880

caaggggcag gtgggggctt ggttgctgac ccggcccaag tccccacaga gcaccttctg   2940

tagctccagc ttgtctccct ggcttctctt tgaaggagaa aaatgtaaaa tatgcactga   3000

gaaagccagc cccgcctgct tagtcagccc cggcagcagg gcagccatgg gaactcagga   3060

aaagcaggaa ccctttccaa aagcccagag atgccctggg ctcagatctg taattctccc   3120

aggagctgtg atagagcagg ccacacaaag tccctacgcc tccctgctgc ctcccccaga   3180

tgcatgtggt ggcatcacca ttccccaaat tgaatatcag catgcggcct gaccagggac   3240

tctttagatg catgaattta tttatatgaa ggctctcaca gagacacaca cagcacttca   3300

gtagcatttg cattcctggt taaagaatca ccaatattta aaataaaaac tttcctgaaa   3360

ttgggactgt catgttatcc agaagggctg gtacatccgc ccaccatgtc cccctgctgg   3420

gtcaggagcc aacacaggac cctgcgtgtg agcgtgcctg acatctcacg cacggccact   3480

ccagagccgg tccctgtcct tggaaagctg tgaagccttg cgttgagttc cttctcgata   3540

ctgacggctc cgtgctgaca ttctgagctc tggagtcaca ccagcgcagg ggcgtggagg   3600

aactgaggtt tggaaggaat gccaggtctc gcacagcttg gcctcgagaa ggtgagagga   3660

aggcaaaggc cagggagggg acccagagag gcctggcaca caaggcccaa gcaccaccgt   3720

caacacagcc cagtccatac agaaatgggt ttcatgcctg aaaagctttt tacagaaaga   3780

tgccgcctgt agccagtgac agccgcaacc ctacaggcct cagttccttg cagaggtgag   3840

gggtagagag tcagcctccc tcccttccag cagcgaccca gcttccctcc acttccaggt   3900

ggtgctgggc tcaccgaggg agcactggtg ggtgctctga aaacccacag gatcccacct   3960

ccaggcccac ctgggtccca tctcactctc ttcttctttc accaattgct aacatagacc   4020

ttgttgggat cacgatggct tcacaagcca gctgttgggt ttgctatgtc actgtggctc   4080

agtcacatcc ctgcgtgtat actgtctgcg gggcacatat gtatccattt agagctaaag   4140

gaatcagtgt acactacagc taatcctaat aaatccgatg ttttcggaaa aa           4192


<210>  846
<211>  303
<212>  PRT
<213>  Homosapiens

<400>  846

Met Pro Glu Glu Ser Ser Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr 
1               5                   10                  15      


Gln Asp Leu Pro His Leu Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys 
            20                  25                  30          


Arg Tyr Trp Lys Pro Thr Gly Thr Pro Lys Ala Leu Ile Phe Val Ser 
        35                  40                  45              


His Gly Ala Gly Glu His Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met 
    50                  55                  60                  


Leu Met Gly Leu Asp Leu Leu Val Phe Ala His Asp His Val Gly His 
65                  70                  75                  80  


Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp Phe His Val Phe 
                85                  90                  95      


Val Arg Asp Val Leu Gln His Val Asp Ser Met Gln Lys Asp Tyr Pro 
            100                 105                 110         


Gly Leu Pro Val Phe Leu Leu Gly His Ser Met Gly Gly Ala Ile Ala 
        115                 120                 125             


Ile Leu Thr Ala Ala Glu Arg Pro Gly His Phe Ala Gly Met Val Leu 
    130                 135                 140                 


Ile Ser Pro Leu Val Leu Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys 
145                 150                 155                 160 


Val Leu Ala Ala Lys Val Leu Asn Leu Val Leu Pro Asn Leu Ser Leu 
                165                 170                 175     


Gly Pro Ile Asp Ser Ser Val Leu Ser Arg Asn Lys Thr Glu Val Asp 
            180                 185                 190         


Ile Tyr Asn Ser Asp Pro Leu Ile Cys Arg Ala Gly Leu Lys Val Cys 
        195                 200                 205             


Phe Gly Ile Gln Leu Leu Asn Ala Val Ser Arg Val Glu Arg Ala Leu 
    210                 215                 220                 


Pro Lys Leu Thr Val Pro Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg 
225                 230                 235                 240 


Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser 
                245                 250                 255     


Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly Ala Tyr His Val Leu His 
            260                 265                 270         


Lys Glu Leu Pro Glu Val Thr Asn Ser Val Phe His Glu Ile Asn Met 
        275                 280                 285             


Trp Val Ser Gln Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro Pro 
    290                 295                 300             


<210>  847
<211>  4617
<212>  DNA
<213>  Homosapiens

<400>  847
ctccatcttt ctagtcccca ccttccccgg tgcagacacc cggcgaagcc cacccggttt     60

tcccagcggc atttccgatg acagcttcgg ggctacgtgt cctgtgctgt cggagacgca    120

caggaagcaa agtttgtgag aagccttggg ggcgactttg ccttgggcac ccgcatttgt    180

gcgtctgcga ggtgcctcgg tgtgcgcgga gctagtttcc cagtttcccg ggcccctccc    240

ttctccgagc ccctctagcg atttgtttag gaaaagtgat gacatgaact agtagtggag    300

aatcgcagcg ccgctccccg ccctggggag ggaggggagc cccggagagc ctgccggtgg    360

gagctggaag caggctcccg gctgagcgcc ccagcccgaa aggcagggtc tgggtgcggg    420

aagagggctc ggagctgcct tcctgctgcc ttggggccgc ccagatgagg gaacagcccg    480

atttgcctgg ttctgattct ccaggctgtc gtggttgtgg aatgcaaacg ccagcacata    540

atggaaacag gacctgaaga cccttccagc atgccagagg aaagttcccc caggcggacc    600

ccgcagagca ttccctacca ggacctccct cacctggtca atgcagacgg acagtacctc    660

ttctgcaggt actggaaacc cacaggcaca cccaaggccc tcatctttgt gtcccatgga    720

gccggagagc acagtggccg ctatgaagag ctggctcgga tgctgatggg gctggacctg    780

ctggtgttcg cccacgacca tgttggccac ggacagagcg aaggggagag gatggtagtg    840

tctgacttcc acgttttcgt cagggatgtg ttgcagcatg tggattccat gcagaaagac    900

taccctgggc ttcctgtctt ccttctgggc cactccatgg gaggcgccat cgccatcctc    960

acggccgcag agaggccggg ccacttcgcc ggcatggtac tcatttcgcc tctggttctt   1020

gccaatcctg aatctgcaac aactttcaag gtccttgctg cgaaagtgct caaccttgtg   1080

ctgccaaact tgtccctcgg gcccatcgac tccagcgtgc tctctcggaa taagacagag   1140

gtcgacattt ataactcaga ccccctgatc tgccgggcag ggctgaaggt gtgcttcggc   1200

atccaactgc tgaatgccgt ctcacgggtg gagcgcgccc tccccaagct gactgtgccc   1260

ttcctgctgc tccagggctc tgccgatcgc ctatgtgaca gcaaaggggc ctacctgctc   1320

atggagttag ccaagagcca ggacaagact ctcaagattt atgaaggtgc ctaccatgtt   1380

ctccacaagg agcttcctga agtcaccaac tccgtcttcc atgaaataaa catgtgggtc   1440

tctcaaagga cagccacggc aggaactgcg tccccaccct gaatgcattg gccggtgccc   1500

ggctcatggt ctgggggatg caggcagggg aagggcagag atggcttctc agatatggct   1560

tgccaaaaaa aaaaaaaaaa aaaaatcaga aattggagaa atccttagca caattttcta   1620

aaaaataaca gacatttttg ttatacatta gactatcaga cactggacct accttaatgg   1680

ttagacactt tatgcaaaaa aagagaaagg tcccaggtga ttttccacaa agaatgtgct   1740

aaaatgtcca ctgaaaacaa agccaagcct ctgccctgcc tctcccagct cccacaaggg   1800

ttccaggaat tcctggtgtt cccaggacac cagactgcaa taactggagg cgcctccttc   1860

ctgcccaccc ttcgctcacg ccccagcgcc ctctctgacc agcctccgct tggtggcctt   1920

cctctggccg tgtgatgagg tggttgctgt ctccataggg gccagctccc cagggcagac   1980

tcacgtgccc ctctgaggct cagaaaatgc ccagcccttc ctcaaaatga gcagccaccc   2040

atgactttgt gggctccttg ttagcctgag accaggcttt gcagaggggc ggggggtgag   2100

gcttagccca gaaggagaac tgagcaggaa accaaggctc ttctctgtcc cctgcccttc   2160

ccctcctgcc agggggaggc tcaggttggt ccccgagtgc cgcctgtact cacaaaggct   2220

gcctttcctc tagagtcact aattttacct gatgctatga gagaatcata ttgaagatga   2280

aatgtctaat atataatgta tattttaaag cagagactat tttggtggat aggtgggagg   2340

gagcaagggg agtttgaggg aatcagagct tgatgctact gtacagaact ggacaggttg   2400

ggccggcagt ggtggggcca gagggctctg tgctctagga gctaagccag cagcccccga   2460

gaggggactt ggctgggcct ttcctatggg caaggcccag tgctcttcct gcccaccagg   2520

gaccatggag cagtggcacc ctatggggct atgatcccta ggcctgggcc tgggcctgcc   2580

tatggcccag agctaccctg ggagtgtcag tgctagcagc acagctacct ctggtggcag   2640

gagaagagag gcccagcaca gcagcaggcc aggccttcct gtccaggtct gcatggagca   2700

ctcggtgacc cagagcaggg actggaggca cccccagccc tgccccaggc cacagcagga   2760

caggccggga caggcctcac ccaaggccaa ggctggcatc agccaatcat tcagagctga   2820

ggccctgggc ctagcctgcc cttctcaggt gccaatacca ccccagccct gcccttggcc   2880

tcactttttc ccagcaataa gtggggttca ccacccgcct cgggaatact ttccccttct   2940

aaatgggact tgctgttacc tcaggaggct ccttagtgca aatatgaccc tggtcagggc   3000

tttgccaccg ttgaagccct gcagaaggtg caatgtaggg gttctggggc cacagaggag   3060

aggccacttc ccaccaggac ccccaacatg aagtctaggc ctcaggggct cccgcccttc   3120

ttcctccagc agcgggaact gccactgctc tcccaggccc tgttctggag gctaaccttg   3180

gttcctggag agtgtgcccc tccaccctcc ctccagcagc cctgatcaca ccatgagagc   3240

caggaacggg tcaccctgct gaagatcact ctgtgccctg ggggaggagc caagccctca   3300

ccccacaagg ggcaggtggg ggcttggttg ctgacccggc ccaagtcccc acagagcacc   3360

ttctgtagct ccagcttgtc tccctggctt ctctttgaag gagaaaaatg taaaatatgc   3420

actgagaaag ccagccccgc ctgcttagtc agccccggca gcagggcagc catgggaact   3480

caggaaaagc aggaaccctt tccaaaagcc cagagatgcc ctgggctcag atctgtaatt   3540

ctcccaggag ctgtgataga gcaggccaca caaagtccct acgcctccct gctgcctccc   3600

ccagatgcat gtggtggcat caccattccc caaattgaat atcagcatgc ggcctgacca   3660

gggactcttt agatgcatga atttatttat atgaaggctc tcacagagac acacacagca   3720

cttcagtagc atttgcattc ctggttaaag aatcaccaat atttaaaata aaaactttcc   3780

tgaaattggg actgtcatgt tatccagaag ggctggtaca tccgcccacc atgtccccct   3840

gctgggtcag gagccaacac aggaccctgc gtgtgagcgt gcctgacatc tcacgcacgg   3900

ccactccaga gccggtccct gtccttggaa agctgtgaag ccttgcgttg agttccttct   3960

cgatactgac ggctccgtgc tgacattctg agctctggag tcacaccagc gcaggggcgt   4020

ggaggaactg aggtttggaa ggaatgccag gtctcgcaca gcttggcctc gagaaggtga   4080

gaggaaggca aaggccaggg aggggaccca gagaggcctg gcacacaagg cccaagcacc   4140

accgtcaaca cagcccagtc catacagaaa tgggtttcat gcctgaaaag ctttttacag   4200

aaagatgccg cctgtagcca gtgacagccg caaccctaca ggcctcagtt ccttgcagag   4260

gtgaggggta gagagtcagc ctccctccct tccagcagcg acccagcttc cctccacttc   4320

caggtggtgc tgggctcacc gagggagcac tggtgggtgc tctgaaaacc cacaggatcc   4380

cacctccagg cccacctggg tcccatctca ctctcttctt ctttcaccaa ttgctaacat   4440

agaccttgtt gggatcacga tggcttcaca agccagctgt tgggtttgct atgtcactgt   4500

ggctcagtca catccctgcg tgtatactgt ctgcggggca catatgtatc catttagagc   4560

taaaggaatc agtgtacact acagctaatc ctaataaatc cgatgttttc ggaaaaa      4617


<210>  848
<211>  313
<212>  PRT
<213>  Homosapiens

<400>  848

Met Glu Thr Gly Pro Glu Asp Pro Ser Ser Met Pro Glu Glu Ser Ser 
1               5                   10                  15      


Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr Gln Asp Leu Pro His Leu 
            20                  25                  30          


Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys Arg Tyr Trp Lys Pro Thr 
        35                  40                  45              


Gly Thr Pro Lys Ala Leu Ile Phe Val Ser His Gly Ala Gly Glu His 
    50                  55                  60                  


Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met Leu Met Gly Leu Asp Leu 
65                  70                  75                  80  


Leu Val Phe Ala His Asp His Val Gly His Gly Gln Ser Glu Gly Glu 
                85                  90                  95      


Arg Met Val Val Ser Asp Phe His Val Phe Val Arg Asp Val Leu Gln 
            100                 105                 110         


His Val Asp Ser Met Gln Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu 
        115                 120                 125             


Leu Gly His Ser Met Gly Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu 
    130                 135                 140                 


Arg Pro Gly His Phe Ala Gly Met Val Leu Ile Ser Pro Leu Val Leu 
145                 150                 155                 160 


Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys Val Leu Ala Ala Lys Val 
                165                 170                 175     


Leu Asn Leu Val Leu Pro Asn Leu Ser Leu Gly Pro Ile Asp Ser Ser 
            180                 185                 190         


Val Leu Ser Arg Asn Lys Thr Glu Val Asp Ile Tyr Asn Ser Asp Pro 
        195                 200                 205             


Leu Ile Cys Arg Ala Gly Leu Lys Val Cys Phe Gly Ile Gln Leu Leu 
    210                 215                 220                 


Asn Ala Val Ser Arg Val Glu Arg Ala Leu Pro Lys Leu Thr Val Pro 
225                 230                 235                 240 


Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg Leu Cys Asp Ser Lys Gly 
                245                 250                 255     


Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser Gln Asp Lys Thr Leu Lys 
            260                 265                 270         


Ile Tyr Glu Gly Ala Tyr His Val Leu His Lys Glu Leu Pro Glu Val 
        275                 280                 285             


Thr Asn Ser Val Phe His Glu Ile Asn Met Trp Val Ser Gln Arg Thr 
    290                 295                 300                 


Ala Thr Ala Gly Thr Ala Ser Pro Pro 
305                 310             


<210>  849
<211>  4121
<212>  DNA
<213>  Homosapiens

<400>  849
agtgtgtgtc aaaaatatat gatggaccac atggatgcct ccaactgttt aggtatctat     60

tattttgcaa agcagattgg agctgaagat ttatctgatc gatcaaagaa atatttatat    120

cagcactttg ccgaggtatc atgatagagg aaaccagttt tgggaaaagt tatgcacagc    180

tgaatttcga gaactctatg ctctggatgg atcttcctga tgaagaacct gatcgattaa    240

gcaacaaact gttgcagtat gaccccagcc aagatcaatg gagtgtgcgg gcacccatga    300

agtactctaa gtaccgattc agtacagctg tagtcaacag tgagatttat gttttgggtg    360

gcattggctg tgtaggtcaa gacaagggcc aggttcgaaa atgccttgac gtggtggaga    420

tctacaaccc agatggggac ttttggcgag agggccctcc catgccaagt cccctcctct    480

cactccgcac caattccacc aatgcagggg cagtggatgg gaaactctat gtctgcgggg    540

gattccatgg agcagatcgc catgaggtta tctccaaaga aatattggaa ctggacccat    600

gggaaaacca gtggaatgtt gtagccatca acgtcctcat gcatgacagc tatgatgtct    660

gcctagtagc caggatgaat ccccgagacc tcatcccccc gccttcagat ttggtggaag    720

aaggcaatga gcactaaggt gaccttgctg gaggacctcc tgctgttctg caaacaaggc    780

cttcagaacg gagagggccc acagcatctc tgtcatgcca gtcatgtgca ctgcatgcgt    840

agtggcctgt gtgtgaagaa gcagtgtgtg ctgggcactg ggtggggagc atggggagtc    900

tcccttcagg gacttcccag cctgataggg taaataagac actacaaaga agaggtgatg    960

acggccacag gaggggcaca gggccacagg agagcagcag agggagggtc tcactctgct   1020

ggggacccat gaacagcact gccaaggagc agacctttta ttgggtcccc aaaaggatga   1080

ggaggaagtg gtcccatggg tgcagtcaat gatgagttca tggaaacagc caagcatggg   1140

cccagagaca gaaagctcgt gcctgtctgc agtatcctgg ctgggccaga ttgcctgggg   1200

cacagggttt gtggtcaagg ctggaaaagt aggttgtagc tagatgacca acgcctgaaa   1260

gaatgaggag ttggacctgg tctgtaagcc agggaattgt ctcaaaatcg tgcattaagg   1320

gagacttctc tctgtgctct gttccagctt cagtcttata aacactgacc attctccttc   1380

agaatcccct tctactgaag caacgccacc cagcagcagg gctagctgta ctaccagccc   1440

ctaacaacca aggcactcaa gccagaccac agtggccaag aatcctgccc tgggctgact   1500

ctgtccggga cagggatgtg gggttctgca gcctggtcca ctccggggct ggcagggagt   1560

gtcctggagt gggctgaccc aggctgcctt tgcccacctc tcagacacat acaaccatct   1620

gcagggtagt cctggctgaa caggactcgc ccaagccacc caagccaggg acagagaagg   1680

ctctggctga ggacagggga agaagcatct cctccagctg ctgccaaccc catggcccgg   1740

cctttgcaat aaagatggag ccacccactt cagcccacaa ttgagcataa tcagaagaca   1800

gtcactccca aaatatatgt tagaaataac atttaaatga cacatgggaa gtccgtctat   1860

cttacttccc gtctctaatt ctggaagcac agtggattca atgagggcat cttcatagct   1920

cttcttcagc aacttctcca aagagtttca cattgcacaa ggctcttttg gaagcaggag   1980

tggtcagtaa attcagaggg agacaaaccc taagtagaga cagctttctt tggtgctgag   2040

ctgtgtgatt gtgatgaccg ctagcctgtg cccctaggtt ccagctgccc accaggcagg   2100

acaggcaggt cttgccaaaa ctggagcctg ttggaaacct atttctgcca ccaaggagag   2160

ggaccaggag acccagcgta ggttggcccc aagtaggctc aactcgggag ggtgggggtc   2220

ccgcctttct cttcgcactt gtgccccaag tgcactcaca gtacctggca tgtgggtgac   2280

ctcttgggtg gccggcatgg ggcagtgttt ctcaatcaga gggcctgggc cccgagcacg   2340

tccaggaatc tgagttaaag tgagcttact ctttccccag tggatgatca tgatctgtgc   2400

attctttttc ttgctacaaa gatgttcctc ctagctgctg tgttggctgt cggcggccag   2460

ggttgaggac ggcctccaca gggcctccac ttccctccat tcctcttcac atagtcactc   2520

cacctgctcc acctgcttga aaagtccaga aagctgccgc gtctccctgg ctcaaggagg   2580

ccttgttggc atgtcatggc acatctccta gatgttttgg gttcaagatc tgggttccag   2640

cccccgctct gctacttagc taaccatgtg aacttgggca agatgacctt tctaaagcct   2700

catttccctc atatgcagag tgggaaggaa aatattaata catactttat agggttggta   2760

tgaggattaa gtgctgagca aagtgcctgt gaaatcctga aataataagc atgttttagc   2820

tgccattatt atcatcactg tcattatcat tgcagtcagc acttcccaaa gcaaggtgcc   2880

caaaacagac tcagtgcttt agggaagtgg ggcagatgtg catatggctt gtgacggttc   2940

tttctttttt tttttttttt tgagacggag tctctctctc tcgccaggct ggagtgcagt   3000

gcagtggcac gatctcagcc cactgcaacc tccgcctccc aggttcaagt gattctcctg   3060

cctcagcctc ccaagtagct gggattacag gcgcccacca ccacacccag ctaatttttg   3120

tatttttagt agagacgggg tttcaccatg ttggccagga tggtctcaat ctcttgacct   3180

cgtgatctgc ccgcctcggc ctcccaaagt gctgggatta caggcatgag cccctgcacc   3240

tggctgagat ggttcttaat ttcccatacc ctgttgcttg gctcctccag ttggcggctg   3300

agagttaagc aagggtttac tcggatctga ggcccccgat gccctcaatg gacacattca   3360

ggaccctgtg gcagctcagc agaggcacct gagggtcacg ctaggtgaga ccatcgcccg   3420

cctgtgggag gcaagataag tgggtaaaca tcattcctgt ctaatgcgag gtctgggcag   3480

tgtcccagtg gaactttcca gagagtgcca agggaggacc gagaaggggc atgacctctg   3540

ctggagccag gagggcagtg accaggagct ggcttagcac tgaagggaag caggcatcaa   3600

gggcaggatt tctcaaactt cttctgagga atccccgagg tcgaaaccgg tgcttcacag   3660

atttcagatg tctgatcttg atttttcttt gattccatac aacagattgc ttgcctgggt   3720

tagtgcttat tttaagttct tggtgcttct tgtctgactt ctgtatttgc aattaaaaac   3780

aacatgaccc tccccacctg cagccagata tcgttagaaa ttcaacttcg aaatatattc   3840

ctatcactcc tgttttcact ttaatagaag gctgttgcag tactgcatga tgggctctta   3900

taaaacttct actatctgct aattcttatc tttgtgacag gattgtttga cactgagcaa   3960

ggaaacacaa taaggaagta atttggatgc taggctggca gaagcctgca gctgtcaacc   4020

acagcctgcc ccagtgtgtt caacacggtg gcattgttct ccctgacttc ataatgagca   4080

aatgtttcac atttgaactt aaggaataaa tttttactaa t                       4121


<210>  850
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  850

Met Ile Glu Glu Thr Ser Phe Gly Lys Ser Tyr Ala Gln Leu Asn Phe 
1               5                   10                  15      


Glu Asn Ser Met Leu Trp Met Asp Leu Pro Asp Glu Glu Pro Asp Arg 
            20                  25                  30          


Leu Ser Asn Lys Leu Leu Gln Tyr Asp Pro Ser Gln Asp Gln Trp Ser 
        35                  40                  45              


Val Arg Ala Pro Met Lys Tyr Ser Lys Tyr Arg Phe Ser Thr Ala Val 
    50                  55                  60                  


Val Asn Ser Glu Ile Tyr Val Leu Gly Gly Ile Gly Cys Val Gly Gln 
65                  70                  75                  80  


Asp Lys Gly Gln Val Arg Lys Cys Leu Asp Val Val Glu Ile Tyr Asn 
                85                  90                  95      


Pro Asp Gly Asp Phe Trp Arg Glu Gly Pro Pro Met Pro Ser Pro Leu 
            100                 105                 110         


Leu Ser Leu Arg Thr Asn Ser Thr Asn Ala Gly Ala Val Asp Gly Lys 
        115                 120                 125             


Leu Tyr Val Cys Gly Gly Phe His Gly Ala Asp Arg His Glu Val Ile 
    130                 135                 140                 


Ser Lys Glu Ile Leu Glu Leu Asp Pro Trp Glu Asn Gln Trp Asn Val 
145                 150                 155                 160 


Val Ala Ile Asn Val Leu Met His Asp Ser Tyr Asp Val Cys Leu Val 
                165                 170                 175     


Ala Arg Met Asn Pro Arg Asp Leu Ile Pro Pro Pro Ser Asp Leu Val 
            180                 185                 190         


Glu Glu Gly Asn Glu His 
        195             


<210>  851
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  851
atgtcggcga ggggcgtggg agctgccacc cgcttgcctg cgggacaccg gagtcaagag     60

gctgcccacg ccgctgcctg tccgttccac ggttccgagg tctccaccgt ctccccgcgc    120

gccgcaggcg gcaccaaact ctgcgctccc cgcggtgcgc cctgcccgcg cagtgcgcgt    180

ccagaggaaa tccgccccgg gctttcgaag tgcagggctg ggggctgcat ggaagtttcc    240

ccaagatttg aagttgaaga tttttcaggt cataatatga tgttgctaat tttgttcctc    300

gtgataattt gttcccatat ttctgtgaac caagattccg gccctgagta tgcagatgtt    360

gtgtttttgg tggacagctc tgatcgcctg ggatccaagt ccttcccatt tgtgaaaatg    420

ttcatcacca aaatgatcag cagtctcccc atagaggccg acaaataccg tgtggccctg    480

gcccagtaca gtgataaact tcacagtgaa ttccacctga gcaccttcaa aggcaggagc    540

cccatgctga accacctaag gaagaacttt ggattcattg gcgggtccct gcagatagga    600

aaggctcttc aggaggctca caggacttat ttctctgcac ccgcaaatgg gagagacaag    660

aaacagtttc ccccaattct agtggtcctg gcttcatctg agtctgagga taatgtggaa    720

gaggcatcaa aggccctgcg gaaagacgga gtgaaaatca tctctgtagg ggtgcagaaa    780

gcttctgagg aaaacctgaa ggccatggcc acgtctcagt ttcatttcaa ccttcggaca    840

gtcagagacc tcagcatgtt ttcccaaaac atgacacaca tcatcaagga tgtaataaag    900

tacaaggagg gagcagttga tgacatcttt gtagaagctt gccaaggccc ttctatggcc    960

gatgttgtgt tcctattgga tatgtcaatc aatggaagtg aggagaactt tgactatctt   1020

aaaggattct tggaagaaag tgtatctgcc cttgacataa aggaaaattg catgagggtt   1080

ggccttgtgg cctatagcaa tgagacaaaa gtgataaatt cactgagcat gggcataaat   1140

aagtcagagg ttctccagca tatacagaac ctttctcccc gaactgggaa ggcctatact   1200

ggagctgcca tcaaaaagct caggaaggaa gtttttagtg cacggaatgg cagtcggaag   1260

aatcaggggg tgccccagat tgccgtgctg gtgacccacc gagattcaga agacaacgtg   1320

acaaaagcag ctgttaacct ccgacgggag ggtgtgacca tcttcaccct gggcatagag   1380

ggcgccagcg acacccagtt ggaaaagata gcatcccacc ctgctgagca gtatgtctcc   1440

aaactgaaga ccttcgctga cctggctgct cacaaccaga catttctgaa gaagctgcgg   1500

aaccaaataa cacacacagt ctctgtcttt tcagagagga ctgaaacgct caaatctggt   1560

tgtgtggaca ctgaggaagc agacatctat ctgcttatcg atggctcagg gagcacccag   1620

gccacagatt tccatgaaat gaagacgttc ctgtcagagg tggtagggat gttcaacatt   1680

gctccccata aggtgcgggt tggggccgtt cagtatgctg acagctggga cttggaattt   1740

gagatcaata aatactccaa caagcaggat ttgggaaagg ccattgagaa tatcaggcag   1800

atgggtggga atacaaacac aggcgcagca ctgaatttca cactgagtct gttgcaaaaa   1860

gcaaagaagc agcgaggaaa caaagttcca tgccaccttg ttgtcctgac aaatggcatg   1920

tccaaggata gcatcttgga gcctgcaaac agactgagag aagagcacat ccgagtttat   1980

gctatcggga tcaaggaggc caaccaaaca cagctgagag aaattgcagg agaggaaaag   2040

agagtgtatt acgtgcatga ctttgatgca ttgaaagaca taagaaacca agttgttcaa   2100

gaaatctgta ctgaagaagc tgacttgaat aaacatcaca gtttttccta tgcagcttgc   2160

aaagagatga aagctgacat catgtttctg gtggacagtt ctggaagtat aggacctgaa   2220

aacttcagca aaatgaaaac atttatgaaa aacctggtga gcaagtctca gattggacca   2280

gatcgggtgc aaattggtgt agtccagttc agcgacatca ataaggaaga gtttcagctc   2340

aacagattca tgtcccaaag cgacatttca aatgcaatag accaaatggc tcacattgga   2400

caaaccaccc tgactggtag tgccctgagc tttgtgtctc agtacttcag ccccaccaag   2460

ggcgcccggc ccaacatcag aaagtttctc atcctcatca cggatggtga agctcaggac   2520

atagtaaagg aaccagcagt agtgcttcgg caagaaggtg taatcatcta ttctgtggga   2580

gtgtttggct ccaatgtcac ccagcttgag gagatcagtg ggaggcccga gatggttttt   2640

tatgttgaga attttgacat tctgcagcgc attgaagatg atcttgtttt tggaatatgc   2700

agcccccgtg aagaatgcaa gcggattgaa gttttagacg ttgtgtttgt cattgatagc   2760

tctggcagta ttgactatga tgagtataat atcatgaagg attttatgat tggcttagtg   2820

aaaaaagctg atgtgggcaa gaatcaggtc cggtttgggg ctctgaagta tgctgatgac   2880

ccagaggtgc tgttttatct ggatgacttt ggcacaaaac tggaggtaat ttcagtgctc   2940

cagaatgacc aagccatggg tggcagtact tatactgctg aggcactggg cttctcagac   3000

cacatgttca ctgaagcccg gggcagccgc ctgaacaagg gggtccccca agtcctcatt   3060

gtgatcaccg atggggaatc ccatgatgct gataaactca atgccacggc aaaggccttg   3120

cgggacaaag gcattcttgt cctggctgtg gggattgatg gtgccaatcc cgtggagctg   3180

ttagccatgg caggatcaag cgacaagtac ttcttcgtgg agacttttgg aggtctgaag   3240

ggaatatttt cagatgtgac agccagtgtc tgcaactctt caaaagtaga ttgtgaaatt   3300

gacaaagtag atcttgtttt ccttatggat ggttcaacta gcattcagcc aaatgacttc   3360

aagaaaatga aggaatttct ggcatctgtt gttcaagact ttgatgtcag cctcaacaga   3420

gtgcgaatag gagcggccca gtttagcgat acctatcacc cggagtttcc actgggaact   3480

ttcataggtg aaaaagagat atcatttcag attgaaaaca tcaagcagat ctttggaaac   3540

acacacatcg gtgctgcact cagggaggtg gaacattact tcaggccaga catgggcagc   3600

aggataaata caggtacccc acaggtgctg ctggtcctta cagatggcca gtcccaagac   3660

gaggtggccc aggccgcgga agccctgaga cacagaggta tcgacatcta ctccgtgggc   3720

attggggatg tggatgacca gcagctcatt cagatcaccg ggactgcaga gaaaaaactg   3780

acagtgcaca acttcgatga actgaagaag gtcaataaaa ggatcgttcg caacatctgt   3840

accacagcgg gtgaaagcaa ctgtttcgtg gatgttgtgg tgggatttga tgtctcaact   3900

caggagaaag ggcagacttt gcttgaaggt cagccttgga tggaaaccta ccttcaagac   3960

atcttacgtg ccatcagctc cctcaatgga gtaagctgtg aggtgggcac agagactcag   4020

gtcagtgtgg cttttcaagt gaccaatgcc atggaaaaat attctcccaa gtttgagatc   4080

tacagtgaaa acatactgaa tagcttgaag gatataacag ttaaaggacc atctcttctc   4140

aatgcaaacc tcttggattc tctatgggat acatttcaga ataaatcagc tgctcgagga   4200

aaggtggtcc ttttattttc agatggattg gatgatgatg ttgagaaact tgaacaaaaa   4260

tctgatgaac ttagaaaaga aggcctgaat gccctcataa ctgttgctct ggatggacct   4320

gctgattcaa gtgacttggc tgatcttccc tatattgaat ttgggaaagg atttgagtac   4380

aggacacagc tctctattgg catgagagaa cttggaagcc ggctgtcaaa gcagctggtc   4440

aatgttgctg aaaggacatg ctgctgtttg ttctgcaagt gcattggagg agatggcaca   4500

atgggagatc ctggaccacc agggaaaagg ggacctccag gttttaaagg cagtgaaggc   4560

tacctgggag aggagggaat cgctggagaa agaggagccc ctggaccagt gggagagcaa   4620

ggtactaagg gatgctatgg caccaaaggt cctaagggaa acagaggact aaatggacag   4680

gagggagaag ttggggaaaa tggaattgac ggattaaacg gagaacaggg tgataatggt   4740

cttcctggaa gaaaaggaga aaagggagat gagggatctc agggaagccc agggaagaga   4800

gggactcctg gtgaccgtgg agcaaagggc ctgcgagggg atcccgtaag tgcacgggct   4860

gcaaactgga gttagggctt gattcccatc cgtacttctg atagggagtc tcgatttcaa   4920

gggagctcct ggagttgaca gtagcataga aggacccaca ggcttgaaag gagaacgtgg   4980

aagacaaggc agaagaggct ggccaggccc ccccgggaca ccaggctcca gaagaaagac   5040

agcagctcat ggcagaaggg gacatacagg cccacaggga acagcaggca tcccaggacc   5100

agatggactt gaaggctccc tgggacttaa gggccctcag ggcccaagag gagaggctgg   5160

tgtgaaagga gaaaaaggag gtgtgggaag taaaggtccc caggggcctc caggacccgg   5220

aggagaggca gggaatcaag gccgtttggg aagccaagga aataaaggag aacctggaga   5280

tctgggagaa aaaggagctg ttggctttcc tggtcctcgt ggcttgcagg gcaatgatgg   5340

cagtccaggt tatggtagtg tcggacgcaa gggagcaaag ggacaagaag gattccctgg   5400

agaaagtgga cctaagggtg agattgggga ccctggtggt ccaggagaga ctgggctgaa   5460

gggagctaga ggcaaaatga tatctgctgg gcttccagga gagatgggat cccctgggga   5520

accaggacct cctggacgta agggtgtgaa aggagccaaa ggcttggctt cattttctac   5580

atgtgagctc attcagtatg tgcgagaccg cagtcctggc aggcatgatt gacgacactg   5640

gcacatttca agtaatagtg gttccctccg gggccgacta cataccagca ttagagagac   5700

tccagcggtg cactttctgc tatgatgtgt gcaagccaga tgcttcttgt gaccaagcca   5760

gaccaccccc tgtgcagtct tacatggatg ctgctttcct tctggatgcc tcccggaaca   5820

tgggaagtgc tgaatttgaa gacataagag ccttccttgg agcactatta gatcactttg   5880

aaatcacccc agagccggag acttctgtca ctggagaccg ggtggcccta ttgagccatg   5940

ctccccccga cttcctaccc aacactcaga agagtccagt tagagctgag ttcaatctta   6000

ccacctacag aagtaagcgc ctcatgaaga ggcatgtgca cgagtcagtt aaacaactaa   6060

atggagatgc ttttattggt catgccttac agtggactct ggacaatgta tttttaagta   6120

cacccaatct gagaagaaac aaagtcatat ttgtgatatc tgctggggaa accagccact   6180

tagatgggga aatcttaaag aaggaatcct tgcgagccaa atgtcaggga tatgccttat   6240

ttgtgttttc ccttggccct atttgggatg acaaggaact ggaggatctc gccagccacc   6300

ctttggatca ccacctggtc cagcttggcc gaattcataa acctgaccac agttatggtg   6360

tgaagtttgt gaagtccttt ataaactcaa tcaggcgtgc aatcaacaaa tatccaccaa   6420

taaacttaaa aataaagtgc aacagactta actctataga tccaaagcag cccccacgac   6480

cattccgaag ctttgttcct ggaccactta aagctaccct caaagaagat gtattacaga   6540

aggcaaaatt ctttcaagat aaaaaatatc tttcaagagt agcaagaagt ggcagagatg   6600

atgctattca aaattttatg agaagcacct cccatacctt taagaatgga aggatgatag   6660

aaagtgctcc caaacaacat gattaaaaaa atgcttgaac aacttagcct taggaagcat   6720

ggtaagactc tggacttaaa tagtaactaa atctgctgcc agaactcaag caacagtttg   6780

taggttatca ggtgacttga ccccctgcat tcattggtat taagatatat cttgttcatt   6840

tatttgacca ctcctgacaa ttccagcact ctacgactga tatgtcgaag aactgtttca   6900

ttagaagaca gaagaatgaa agaagtgttt tgaaaagtct aatggagata taatttgaag   6960

gtaaaattta tatgatgtat gcatatgtgt acatgggtca atgttaattc ttttatctct   7020

gtccagttca ttttctgcaa acccatcctc ctttcctaat ttagtaatgt ctaatgctca   7080

tctatttagt caaagttatt ttttaatgtt ttaagctact ccaaaattta tcctagaaat   7140

ggatgctgtt tatatgtcgt atttttttaa aacgtgacct tctattccac ttaaacacac   7200

cactgtggga gttgtttgct tggactgatg agaagagggt aattttctcc atctctaaat   7260

cctcctgaac tcactgaaaa actcattaat tcccgcagaa cataaattat tgcttttgag   7320

ctggaagttt tctcttcatt aggaagctta ctgccatttt gatggagctt gaagccccca   7380

ttttgatgga cttctagtct gtctttcctg ttatggtcat ttattaattt tcactaatcc   7440

atatattctt tagacaagga gagtcaagaa actacttgtc atagatgaag ctctgagtta   7500

cttttaccca tcaggtagct gtttagtcaa taataaacag caccaaaaca ggattagcag   7560

agctcttaaa aacagcctta aatacacact gagtttagaa aaatgtaaga aaatcattgt   7620

tttaatctac aaattcatat gcagttgcag agatgcaaaa gagatcagag taagttaaag   7680

taggaaaggt tttataaaag tattgatggc tgtgtcctca tctgcatttt tgtttttatg   7740

atagggctga tattttcaac aacgaaacac ccaatgttca gaccttacct cagtctaaga   7800

gctggctcca cagttggtag caatggccct gttaggcaga ctgtccccct ctttgggaat   7860

ggaaagaagc cctgcctgga tgcatggagc agatggatac tgacaccaag gacattcaga   7920

ttttctttcc tatacctatt ttcataaaat ttggaaagaa aaactatctg cagtattttt   7980

ttaaaacgac ttctgctatt cttacttaga gaaatccagt gatagcacct catgtcttca   8040

gaggagcaag aagttcaagg agttaaatgt cacattcata ctcaggtaat agagaagaat   8100

aaaacacatc aggtttgctt catctatcct aagtggtgct taggggttca gaaaaaatgt   8160

ttcaagtaca ggaaattaat gagcaatatt ta                                 8192


<210>  852
<211>  1624
<212>  PRT
<213>  Homosapiens

<400>  852

Met Ser Ala Arg Gly Val Gly Ala Ala Thr Arg Leu Pro Ala Gly His 
1               5                   10                  15      


Arg Ser Gln Glu Ala Ala His Ala Ala Ala Cys Pro Phe His Gly Ser 
            20                  25                  30          


Glu Val Ser Thr Val Ser Pro Arg Ala Ala Gly Gly Thr Lys Leu Cys 
        35                  40                  45              


Ala Pro Arg Gly Ala Pro Cys Pro Arg Ser Ala Arg Pro Glu Glu Ile 
    50                  55                  60                  


Arg Pro Gly Leu Ser Lys Cys Arg Ala Gly Gly Cys Met Glu Val Ser 
65                  70                  75                  80  


Pro Arg Phe Glu Val Glu Asp Phe Ser Gly His Asn Met Met Leu Leu 
                85                  90                  95      


Ile Leu Phe Leu Val Ile Ile Cys Ser His Ile Ser Val Asn Gln Asp 
            100                 105                 110         


Ser Gly Pro Glu Tyr Ala Asp Val Val Phe Leu Val Asp Ser Ser Asp 
        115                 120                 125             


Arg Leu Gly Ser Lys Ser Phe Pro Phe Val Lys Met Phe Ile Thr Lys 
    130                 135                 140                 


Met Ile Ser Ser Leu Pro Ile Glu Ala Asp Lys Tyr Arg Val Ala Leu 
145                 150                 155                 160 


Ala Gln Tyr Ser Asp Lys Leu His Ser Glu Phe His Leu Ser Thr Phe 
                165                 170                 175     


Lys Gly Arg Ser Pro Met Leu Asn His Leu Arg Lys Asn Phe Gly Phe 
            180                 185                 190         


Ile Gly Gly Ser Leu Gln Ile Gly Lys Ala Leu Gln Glu Ala His Arg 
        195                 200                 205             


Thr Tyr Phe Ser Ala Pro Ala Asn Gly Arg Asp Lys Lys Gln Phe Pro 
    210                 215                 220                 


Pro Ile Leu Val Val Leu Ala Ser Ser Glu Ser Glu Asp Asn Val Glu 
225                 230                 235                 240 


Glu Ala Ser Lys Ala Leu Arg Lys Asp Gly Val Lys Ile Ile Ser Val 
                245                 250                 255     


Gly Val Gln Lys Ala Ser Glu Glu Asn Leu Lys Ala Met Ala Thr Ser 
            260                 265                 270         


Gln Phe His Phe Asn Leu Arg Thr Val Arg Asp Leu Ser Met Phe Ser 
        275                 280                 285             


Gln Asn Met Thr His Ile Ile Lys Asp Val Ile Lys Tyr Lys Glu Gly 
    290                 295                 300                 


Ala Val Asp Asp Ile Phe Val Glu Ala Cys Gln Gly Pro Ser Met Ala 
305                 310                 315                 320 


Asp Val Val Phe Leu Leu Asp Met Ser Ile Asn Gly Ser Glu Glu Asn 
                325                 330                 335     


Phe Asp Tyr Leu Lys Gly Phe Leu Glu Glu Ser Val Ser Ala Leu Asp 
            340                 345                 350         


Ile Lys Glu Asn Cys Met Arg Val Gly Leu Val Ala Tyr Ser Asn Glu 
        355                 360                 365             


Thr Lys Val Ile Asn Ser Leu Ser Met Gly Ile Asn Lys Ser Glu Val 
    370                 375                 380                 


Leu Gln His Ile Gln Asn Leu Ser Pro Arg Thr Gly Lys Ala Tyr Thr 
385                 390                 395                 400 


Gly Ala Ala Ile Lys Lys Leu Arg Lys Glu Val Phe Ser Ala Arg Asn 
                405                 410                 415     


Gly Ser Arg Lys Asn Gln Gly Val Pro Gln Ile Ala Val Leu Val Thr 
            420                 425                 430         


His Arg Asp Ser Glu Asp Asn Val Thr Lys Ala Ala Val Asn Leu Arg 
        435                 440                 445             


Arg Glu Gly Val Thr Ile Phe Thr Leu Gly Ile Glu Gly Ala Ser Asp 
    450                 455                 460                 


Thr Gln Leu Glu Lys Ile Ala Ser His Pro Ala Glu Gln Tyr Val Ser 
465                 470                 475                 480 


Lys Leu Lys Thr Phe Ala Asp Leu Ala Ala His Asn Gln Thr Phe Leu 
                485                 490                 495     


Lys Lys Leu Arg Asn Gln Ile Thr His Thr Val Ser Val Phe Ser Glu 
            500                 505                 510         


Arg Thr Glu Thr Leu Lys Ser Gly Cys Val Asp Thr Glu Glu Ala Asp 
        515                 520                 525             


Ile Tyr Leu Leu Ile Asp Gly Ser Gly Ser Thr Gln Ala Thr Asp Phe 
    530                 535                 540                 


His Glu Met Lys Thr Phe Leu Ser Glu Val Val Gly Met Phe Asn Ile 
545                 550                 555                 560 


Ala Pro His Lys Val Arg Val Gly Ala Val Gln Tyr Ala Asp Ser Trp 
                565                 570                 575     


Asp Leu Glu Phe Glu Ile Asn Lys Tyr Ser Asn Lys Gln Asp Leu Gly 
            580                 585                 590         


Lys Ala Ile Glu Asn Ile Arg Gln Met Gly Gly Asn Thr Asn Thr Gly 
        595                 600                 605             


Ala Ala Leu Asn Phe Thr Leu Ser Leu Leu Gln Lys Ala Lys Lys Gln 
    610                 615                 620                 


Arg Gly Asn Lys Val Pro Cys His Leu Val Val Leu Thr Asn Gly Met 
625                 630                 635                 640 


Ser Lys Asp Ser Ile Leu Glu Pro Ala Asn Arg Leu Arg Glu Glu His 
                645                 650                 655     


Ile Arg Val Tyr Ala Ile Gly Ile Lys Glu Ala Asn Gln Thr Gln Leu 
            660                 665                 670         


Arg Glu Ile Ala Gly Glu Glu Lys Arg Val Tyr Tyr Val His Asp Phe 
        675                 680                 685             


Asp Ala Leu Lys Asp Ile Arg Asn Gln Val Val Gln Glu Ile Cys Thr 
    690                 695                 700                 


Glu Glu Ala Asp Leu Asn Lys His His Ser Phe Ser Tyr Ala Ala Cys 
705                 710                 715                 720 


Lys Glu Met Lys Ala Asp Ile Met Phe Leu Val Asp Ser Ser Gly Ser 
                725                 730                 735     


Ile Gly Pro Glu Asn Phe Ser Lys Met Lys Thr Phe Met Lys Asn Leu 
            740                 745                 750         


Val Ser Lys Ser Gln Ile Gly Pro Asp Arg Val Gln Ile Gly Val Val 
        755                 760                 765             


Gln Phe Ser Asp Ile Asn Lys Glu Glu Phe Gln Leu Asn Arg Phe Met 
    770                 775                 780                 


Ser Gln Ser Asp Ile Ser Asn Ala Ile Asp Gln Met Ala His Ile Gly 
785                 790                 795                 800 


Gln Thr Thr Leu Thr Gly Ser Ala Leu Ser Phe Val Ser Gln Tyr Phe 
                805                 810                 815     


Ser Pro Thr Lys Gly Ala Arg Pro Asn Ile Arg Lys Phe Leu Ile Leu 
            820                 825                 830         


Ile Thr Asp Gly Glu Ala Gln Asp Ile Val Lys Glu Pro Ala Val Val 
        835                 840                 845             


Leu Arg Gln Glu Gly Val Ile Ile Tyr Ser Val Gly Val Phe Gly Ser 
    850                 855                 860                 


Asn Val Thr Gln Leu Glu Glu Ile Ser Gly Arg Pro Glu Met Val Phe 
865                 870                 875                 880 


Tyr Val Glu Asn Phe Asp Ile Leu Gln Arg Ile Glu Asp Asp Leu Val 
                885                 890                 895     


Phe Gly Ile Cys Ser Pro Arg Glu Glu Cys Lys Arg Ile Glu Val Leu 
            900                 905                 910         


Asp Val Val Phe Val Ile Asp Ser Ser Gly Ser Ile Asp Tyr Asp Glu 
        915                 920                 925             


Tyr Asn Ile Met Lys Asp Phe Met Ile Gly Leu Val Lys Lys Ala Asp 
    930                 935                 940                 


Val Gly Lys Asn Gln Val Arg Phe Gly Ala Leu Lys Tyr Ala Asp Asp 
945                 950                 955                 960 


Pro Glu Val Leu Phe Tyr Leu Asp Asp Phe Gly Thr Lys Leu Glu Val 
                965                 970                 975     


Ile Ser Val Leu Gln Asn Asp Gln Ala Met Gly Gly Ser Thr Tyr Thr 
            980                 985                 990         


Ala Glu Ala Leu Gly Phe Ser Asp  His Met Phe Thr Glu  Ala Arg Gly 
        995                 1000                 1005             


Ser Arg  Leu Asn Lys Gly Val  Pro Gln Val Leu Ile  Val Ile Thr 
    1010                 1015                 1020             


Asp Gly  Glu Ser His Asp Ala  Asp Lys Leu Asn Ala  Thr Ala Lys 
    1025                 1030                 1035             


Ala Leu  Arg Asp Lys Gly Ile  Leu Val Leu Ala Val  Gly Ile Asp 
    1040                 1045                 1050             


Gly Ala  Asn Pro Val Glu Leu  Leu Ala Met Ala Gly  Ser Ser Asp 
    1055                 1060                 1065             


Lys Tyr  Phe Phe Val Glu Thr  Phe Gly Gly Leu Lys  Gly Ile Phe 
    1070                 1075                 1080             


Ser Asp  Val Thr Ala Ser Val  Cys Asn Ser Ser Lys  Val Asp Cys 
    1085                 1090                 1095             


Glu Ile  Asp Lys Val Asp Leu  Val Phe Leu Met Asp  Gly Ser Thr 
    1100                 1105                 1110             


Ser Ile  Gln Pro Asn Asp Phe  Lys Lys Met Lys Glu  Phe Leu Ala 
    1115                 1120                 1125             


Ser Val  Val Gln Asp Phe Asp  Val Ser Leu Asn Arg  Val Arg Ile 
    1130                 1135                 1140             


Gly Ala  Ala Gln Phe Ser Asp  Thr Tyr His Pro Glu  Phe Pro Leu 
    1145                 1150                 1155             


Gly Thr  Phe Ile Gly Glu Lys  Glu Ile Ser Phe Gln  Ile Glu Asn 
    1160                 1165                 1170             


Ile Lys  Gln Ile Phe Gly Asn  Thr His Ile Gly Ala  Ala Leu Arg 
    1175                 1180                 1185             


Glu Val  Glu His Tyr Phe Arg  Pro Asp Met Gly Ser  Arg Ile Asn 
    1190                 1195                 1200             


Thr Gly  Thr Pro Gln Val Leu  Leu Val Leu Thr Asp  Gly Gln Ser 
    1205                 1210                 1215             


Gln Asp  Glu Val Ala Gln Ala  Ala Glu Ala Leu Arg  His Arg Gly 
    1220                 1225                 1230             


Ile Asp  Ile Tyr Ser Val Gly  Ile Gly Asp Val Asp  Asp Gln Gln 
    1235                 1240                 1245             


Leu Ile  Gln Ile Thr Gly Thr  Ala Glu Lys Lys Leu  Thr Val His 
    1250                 1255                 1260             


Asn Phe  Asp Glu Leu Lys Lys  Val Asn Lys Arg Ile  Val Arg Asn 
    1265                 1270                 1275             


Ile Cys  Thr Thr Ala Gly Glu  Ser Asn Cys Phe Val  Asp Val Val 
    1280                 1285                 1290             


Val Gly  Phe Asp Val Ser Thr  Gln Glu Lys Gly Gln  Thr Leu Leu 
    1295                 1300                 1305             


Glu Gly  Gln Pro Trp Met Glu  Thr Tyr Leu Gln Asp  Ile Leu Arg 
    1310                 1315                 1320             


Ala Ile  Ser Ser Leu Asn Gly  Val Ser Cys Glu Val  Gly Thr Glu 
    1325                 1330                 1335             


Thr Gln  Val Ser Val Ala Phe  Gln Val Thr Asn Ala  Met Glu Lys 
    1340                 1345                 1350             


Tyr Ser  Pro Lys Phe Glu Ile  Tyr Ser Glu Asn Ile  Leu Asn Ser 
    1355                 1360                 1365             


Leu Lys  Asp Ile Thr Val Lys  Gly Pro Ser Leu Leu  Asn Ala Asn 
    1370                 1375                 1380             


Leu Leu  Asp Ser Leu Trp Asp  Thr Phe Gln Asn Lys  Ser Ala Ala 
    1385                 1390                 1395             


Arg Gly  Lys Val Val Leu Leu  Phe Ser Asp Gly Leu  Asp Asp Asp 
    1400                 1405                 1410             


Val Glu  Lys Leu Glu Gln Lys  Ser Asp Glu Leu Arg  Lys Glu Gly 
    1415                 1420                 1425             


Leu Asn  Ala Leu Ile Thr Val  Ala Leu Asp Gly Pro  Ala Asp Ser 
    1430                 1435                 1440             


Ser Asp  Leu Ala Asp Leu Pro  Tyr Ile Glu Phe Gly  Lys Gly Phe 
    1445                 1450                 1455             


Glu Tyr  Arg Thr Gln Leu Ser  Ile Gly Met Arg Glu  Leu Gly Ser 
    1460                 1465                 1470             


Arg Leu  Ser Lys Gln Leu Val  Asn Val Ala Glu Arg  Thr Cys Cys 
    1475                 1480                 1485             


Cys Leu  Phe Cys Lys Cys Ile  Gly Gly Asp Gly Thr  Met Gly Asp 
    1490                 1495                 1500             


Pro Gly  Pro Pro Gly Lys Arg  Gly Pro Pro Gly Phe  Lys Gly Ser 
    1505                 1510                 1515             


Glu Gly  Tyr Leu Gly Glu Glu  Gly Ile Ala Gly Glu  Arg Gly Ala 
    1520                 1525                 1530             


Pro Gly  Pro Val Gly Glu Gln  Gly Thr Lys Gly Cys  Tyr Gly Thr 
    1535                 1540                 1545             


Lys Gly  Pro Lys Gly Asn Arg  Gly Leu Asn Gly Gln  Glu Gly Glu 
    1550                 1555                 1560             


Val Gly  Glu Asn Gly Ile Asp  Gly Leu Asn Gly Glu  Gln Gly Asp 
    1565                 1570                 1575             


Asn Gly  Leu Pro Gly Arg Lys  Gly Glu Lys Gly Asp  Glu Gly Ser 
    1580                 1585                 1590             


Gln Gly  Ser Pro Gly Lys Arg  Gly Thr Pro Gly Asp  Arg Gly Ala 
    1595                 1600                 1605             


Lys Gly  Leu Arg Gly Asp Pro  Val Ser Ala Arg Ala  Ala Asn Trp 
    1610                 1615                 1620             


Ser 
    


<210>  853
<211>  5060
<212>  DNA
<213>  Homosapiens

<400>  853
gcacgagggg agttcggcgt ttgctggggc tgcagcagct gaagtgtagt gttttcttgg     60

gactggcggt ctgcacttct ctcccgggtt ccatctcccc ccgcccggtg gtgaggccct    120

cgaggagggc tcggacgggt gtagcgatcc gcgctagagg aagacgaggc ccgggaacgc    180

atgtccccca gggcaggtta gggggctgga ggggtcaaat cccggggtac ttgtggagac    240

tctttagcgt ggcttcttct ctctgctgag accccgagag ctttcccagt tctcctccca    300

ggaccaccgg ggttcctgaa gatcgggact tttctgcgcc cctccaccaa cagcccatct    360

cctgtctatg aagaaagacc cttcgtagaa acaacttccc cgctgctgac gcgttttccc    420

gtcccgtccc cgaagtagtc tactatgacc tcgttgtgag cctctgaacg attttgacac    480

tttcccgagg cctagggtat tatatcctaa ccttactaaa gaccacagag gtgcttgcca    540

ttatgggaaa tcagcttgct ggcattgctc cctcccagat cctttctgta gagagttatt    600

tttcagatat tcatgacttt gaatatgata aaagcctggg gagtactcgg ttttttaaag    660

ttgctcgagc caagcaccga gaaggcctgg tcgttgtgaa ggtttttgca attcaggatc    720

ccacattgcc tttaaccagc tataaacaag agctggagga actgaaaatc aggcttaatt    780

ctgcacagaa ttgtctacct ttccagaaag catcagaaaa agcatctgag aaagcagcta    840

tgctctttag gcagtatgtg cgagacaatc tctatgatcg catcagtacc cgtccattct    900

tgaataacat tgagaagcgc tggattgctt tccagatcct gacagctgtg gaccaagcac    960

acaaatctgg agttcgtcat ggggacatca agactgagaa tgtgatggtc accagttgga   1020

attgggttct tctaactgat tttgccagtt ttaagcccac ttatcttcca gaagacaacc   1080

cggcagattt caattatttc tttgacacat cacggaggag aacttgctat attgctcctg   1140

aacgttttgt tgatggtggg atgtttgcca ctgagttaga atatatgaga gatccttcaa   1200

ctccgcttgt agacttaaat agcaatcaga gaacaagagg agagttgaag agagcaatgg   1260

acatcttttc agcaggttgt gtgatagctg agctttttac agaaggtgta ccattatttg   1320

atctctctca acttttggct tatagaaatg gacatttttt ccctgaacaa gtgctaaata   1380

aaattgaaga tcacagtatc agagaattgg taactcagat gattcaccgt gagccagata   1440

aacgtttaga ggcagaagat tacttaaaac agcagcgtgg caatgccttt cctgaaatat   1500

tttacacttt tcttcagccc tacatggccc agtttgccaa ggaaacgttt ctttctgcag   1560

atgagcgtat tctggttata cggaaggatt tgggcaacat tattcacaat ctctgtggac   1620

atgatctgcc agaaaaagcc gaaggagagc ctaaggaaaa tgggctggtt atcttggtat   1680

ctgttataac atcctgccta cagaccctta aatactgtga ttccaaacta gctgctttgg   1740

aactgattct tcatttggct ccaagattaa gtgttgaaat ccttttggat cgtattactc   1800

catatctttt gcatttcagc aatgactctg ttcctagggt gagggctgaa gccttgagga   1860

cgttgaccaa agttcttgct ctcgtcaaag aggttcctcg taatgatatc aatatttatc   1920

cggaatacat tctgccaggc atagcccact tagcccaaga tgatgctact atcgttagac   1980

tagcctatgc tgaaaacata gctctgctgg cagaaacagc tctgagattc ctggaattag   2040

tacagttaaa aaatcttaat atggaaaatg accccaataa tgaagaaata gatgaggtta   2100

cacatccaaa tggaaattat gacacagagc tccaagcctt acatgaaatg gtccagcaga   2160

aagttgttac tttgctaagt gaccctgaaa atattgtaaa acaaaccttg atggaaaatg   2220

gaataacacg gctgtgtgta ttctttggac gtcagaaagc caacgatgtt ttgttgtccc   2280

acatgattac tttcctaaat gataagaatg attggcatct acgtggagca ttttttgata   2340

gtatagttgg tgttgctgcc tatgttggct ggcaaagctc ctcaattctc aagcctctgc   2400

tgcaacaagg tcttagtgat gctgaggaat ttgtcattgt gaaagctctt tatgccctta   2460

cttgtatgtg ccagttagga ctgctacaaa aaccccatgt ttacgaattt gccagtgata   2520

ttgccccctt cctgtgtcat cccaatttat ggatacgtta tggtgccgtg ggatttatca   2580

cagtggtagc tcgtcaaata agtacagctg atgtctactg taaactgatg ccttatcttg   2640

acccatatat tacccaacca ataatacaga ttgaaagaaa acttgttctg ctcagtgttt   2700

taaaggaacc agtaagtcgt tctatatttg attatgcttt gaggtctaaa gatattacta   2760

gcttgttcag acatcttcac atgcgtcaga agaaacgaaa tggttctctt cccgactgcc   2820

ctccgccaga ggatcctgcc atagcacagc ttctgaagaa gttgctctca cagggaatga   2880

cagaggaaga ggaagacaaa cttctggcac tgaaagactt catgatgaaa tctaataaag   2940

caaaggccaa tatagtggac cagagccatc ttcatgatag tagtcagaaa ggtgtaattg   3000

acttggcagc tttaggcata actgggagac aagttgatct tgttaaaacc aaacaagaac   3060

cagatgacaa acgggccaga aaacatgtaa aacaagactc aaatgtaaat gaagaatgga   3120

aaagcatgtt tgggtcactg gacccaccaa acatgccaca ggccctacct aaagggagtg   3180

atcaggaggt gattcagact gggaaacctc ctcgttccga gtcctctgct ggcatttgtg   3240

tccctttgtc aacttcttca caggttccag aagtgacaac tgtccaaaat aaaaaaccag   3300

taataccggt tttaagtagt acaatcttac catccaccta tcagattcga attacaactt   3360

gtaaaactga acttcagcaa ctcatccagc aaaagcggga gcagtgcaat gctgagagaa   3420

tagctaagca gatgatggaa aatgctgaat gggagagtaa accaccacca cctggatggc   3480

gtcctaaagg gctgttagtt gcccatcttc atgagcataa atctgctgtg aatcgaatta   3540

gagtctctga tgaacactca ctttttgcaa catgttcaaa tgatggcaca gtgaaaatct   3600

ggaacagtca aaagatggag gggaagacca ccactaccag atctattctt acatacagcc   3660

gaattggagg acgagtcaag acgctcacat tctgccaagg ctcccactat ttagccatag   3720

catctgataa tggtgctgtc cagcttcttg gaattgaggc ttctaagctg cccaagtctc   3780

ctaaaatcca tcctctacaa agcagaattc tagatcagaa ggaggacggt tgtgttgtgg   3840

atatgcatca cttcaactct ggagcacagt ctgttcttgc ctatgccact gtgaatggct   3900

ctctggttgg ctgggacctt aggtcttcaa gcaatgcgtg gactttaaag catgatttaa   3960

agtcgggcct catcacttcc tttgctgtgg acatccacca atgctggctc tgcattggta   4020

caagcagtgg taccatggct tgttgggaca tgaggttcca gttgccaatt tcaagtcact   4080

gtcatccttc cagggctcga atcagacgcc tctcaatgca ccctctgtat cagtcctggg   4140

tgattgcagc tgttcagggc aacaacgaag tgtccatgtg ggacatggag actggtgaca   4200

gaagatttac tctctgggcc agcagtgcac caccactttc tgaattacag ccttctcctc   4260

atagcgtcca tggtatctac tgtagtcctg cagatggaaa tcctatccta ctaacagctg   4320

gctcagatat gaaaataagg ttttgggact tggcttaccc agaaaggtcc tatgttgttg   4380

caggaagtac tagttcccca tctgtgtcct actacaggaa aataattgaa ggcactgaag   4440

ttgtccagga aattcagaat aagcagaaag taggaccaag tgatgacacc cctcgaaggg   4500

gcccagagtc cctgcccgtg ggacatcatg acatcatcac tgatgtcgcc acattccaga   4560

ccacacaggg cttcatcgta actgcttcta gagatgggat tgtgaaggtg tggaaataaa   4620

acctactgat ttgtataaat tttaatagtt ataaatataa tactataact cgagaaaagg   4680

catttctaga gaacagattc atttgcttaa ttttcaaaat tatgtctcca tattactgtt   4740

tcatgactga ctgactaaat gacacccaaa atggttaaga tgtacttgac tagtttactt   4800

atgcatctct ttgcaagaat cagccagcca acaatgtctg ggatttttat tgtatatgtt   4860

atagaggtga gaaatgtaaa atatgaaaat gaatatgttt attttgtatt gaaaaagatg   4920

gttgaaaaga tggttgtaag ctattatagt ataaacacat ttttgctatt aaaaatgcta   4980

ttcaaagcag ttaaactgta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaac   5040

tcgagggggg gcccggtacc                                               5060


<210>  854
<211>  1358
<212>  PRT
<213>  Homosapiens

<400>  854

Met Gly Asn Gln Leu Ala Gly Ile Ala Pro Ser Gln Ile Leu Ser Val 
1               5                   10                  15      


Glu Ser Tyr Phe Ser Asp Ile His Asp Phe Glu Tyr Asp Lys Ser Leu 
            20                  25                  30          


Gly Ser Thr Arg Phe Phe Lys Val Ala Arg Ala Lys His Arg Glu Gly 
        35                  40                  45              


Leu Val Val Val Lys Val Phe Ala Ile Gln Asp Pro Thr Leu Pro Leu 
    50                  55                  60                  


Thr Ser Tyr Lys Gln Glu Leu Glu Glu Leu Lys Ile Arg Leu Asn Ser 
65                  70                  75                  80  


Ala Gln Asn Cys Leu Pro Phe Gln Lys Ala Ser Glu Lys Ala Ser Glu 
                85                  90                  95      


Lys Ala Ala Met Leu Phe Arg Gln Tyr Val Arg Asp Asn Leu Tyr Asp 
            100                 105                 110         


Arg Ile Ser Thr Arg Pro Phe Leu Asn Asn Ile Glu Lys Arg Trp Ile 
        115                 120                 125             


Ala Phe Gln Ile Leu Thr Ala Val Asp Gln Ala His Lys Ser Gly Val 
    130                 135                 140                 


Arg His Gly Asp Ile Lys Thr Glu Asn Val Met Val Thr Ser Trp Asn 
145                 150                 155                 160 


Trp Val Leu Leu Thr Asp Phe Ala Ser Phe Lys Pro Thr Tyr Leu Pro 
                165                 170                 175     


Glu Asp Asn Pro Ala Asp Phe Asn Tyr Phe Phe Asp Thr Ser Arg Arg 
            180                 185                 190         


Arg Thr Cys Tyr Ile Ala Pro Glu Arg Phe Val Asp Gly Gly Met Phe 
        195                 200                 205             


Ala Thr Glu Leu Glu Tyr Met Arg Asp Pro Ser Thr Pro Leu Val Asp 
    210                 215                 220                 


Leu Asn Ser Asn Gln Arg Thr Arg Gly Glu Leu Lys Arg Ala Met Asp 
225                 230                 235                 240 


Ile Phe Ser Ala Gly Cys Val Ile Ala Glu Leu Phe Thr Glu Gly Val 
                245                 250                 255     


Pro Leu Phe Asp Leu Ser Gln Leu Leu Ala Tyr Arg Asn Gly His Phe 
            260                 265                 270         


Phe Pro Glu Gln Val Leu Asn Lys Ile Glu Asp His Ser Ile Arg Glu 
        275                 280                 285             


Leu Val Thr Gln Met Ile His Arg Glu Pro Asp Lys Arg Leu Glu Ala 
    290                 295                 300                 


Glu Asp Tyr Leu Lys Gln Gln Arg Gly Asn Ala Phe Pro Glu Ile Phe 
305                 310                 315                 320 


Tyr Thr Phe Leu Gln Pro Tyr Met Ala Gln Phe Ala Lys Glu Thr Phe 
                325                 330                 335     


Leu Ser Ala Asp Glu Arg Ile Leu Val Ile Arg Lys Asp Leu Gly Asn 
            340                 345                 350         


Ile Ile His Asn Leu Cys Gly His Asp Leu Pro Glu Lys Ala Glu Gly 
        355                 360                 365             


Glu Pro Lys Glu Asn Gly Leu Val Ile Leu Val Ser Val Ile Thr Ser 
    370                 375                 380                 


Cys Leu Gln Thr Leu Lys Tyr Cys Asp Ser Lys Leu Ala Ala Leu Glu 
385                 390                 395                 400 


Leu Ile Leu His Leu Ala Pro Arg Leu Ser Val Glu Ile Leu Leu Asp 
                405                 410                 415     


Arg Ile Thr Pro Tyr Leu Leu His Phe Ser Asn Asp Ser Val Pro Arg 
            420                 425                 430         


Val Arg Ala Glu Ala Leu Arg Thr Leu Thr Lys Val Leu Ala Leu Val 
        435                 440                 445             


Lys Glu Val Pro Arg Asn Asp Ile Asn Ile Tyr Pro Glu Tyr Ile Leu 
    450                 455                 460                 


Pro Gly Ile Ala His Leu Ala Gln Asp Asp Ala Thr Ile Val Arg Leu 
465                 470                 475                 480 


Ala Tyr Ala Glu Asn Ile Ala Leu Leu Ala Glu Thr Ala Leu Arg Phe 
                485                 490                 495     


Leu Glu Leu Val Gln Leu Lys Asn Leu Asn Met Glu Asn Asp Pro Asn 
            500                 505                 510         


Asn Glu Glu Ile Asp Glu Val Thr His Pro Asn Gly Asn Tyr Asp Thr 
        515                 520                 525             


Glu Leu Gln Ala Leu His Glu Met Val Gln Gln Lys Val Val Thr Leu 
    530                 535                 540                 


Leu Ser Asp Pro Glu Asn Ile Val Lys Gln Thr Leu Met Glu Asn Gly 
545                 550                 555                 560 


Ile Thr Arg Leu Cys Val Phe Phe Gly Arg Gln Lys Ala Asn Asp Val 
                565                 570                 575     


Leu Leu Ser His Met Ile Thr Phe Leu Asn Asp Lys Asn Asp Trp His 
            580                 585                 590         


Leu Arg Gly Ala Phe Phe Asp Ser Ile Val Gly Val Ala Ala Tyr Val 
        595                 600                 605             


Gly Trp Gln Ser Ser Ser Ile Leu Lys Pro Leu Leu Gln Gln Gly Leu 
    610                 615                 620                 


Ser Asp Ala Glu Glu Phe Val Ile Val Lys Ala Leu Tyr Ala Leu Thr 
625                 630                 635                 640 


Cys Met Cys Gln Leu Gly Leu Leu Gln Lys Pro His Val Tyr Glu Phe 
                645                 650                 655     


Ala Ser Asp Ile Ala Pro Phe Leu Cys His Pro Asn Leu Trp Ile Arg 
            660                 665                 670         


Tyr Gly Ala Val Gly Phe Ile Thr Val Val Ala Arg Gln Ile Ser Thr 
        675                 680                 685             


Ala Asp Val Tyr Cys Lys Leu Met Pro Tyr Leu Asp Pro Tyr Ile Thr 
    690                 695                 700                 


Gln Pro Ile Ile Gln Ile Glu Arg Lys Leu Val Leu Leu Ser Val Leu 
705                 710                 715                 720 


Lys Glu Pro Val Ser Arg Ser Ile Phe Asp Tyr Ala Leu Arg Ser Lys 
                725                 730                 735     


Asp Ile Thr Ser Leu Phe Arg His Leu His Met Arg Gln Lys Lys Arg 
            740                 745                 750         


Asn Gly Ser Leu Pro Asp Cys Pro Pro Pro Glu Asp Pro Ala Ile Ala 
        755                 760                 765             


Gln Leu Leu Lys Lys Leu Leu Ser Gln Gly Met Thr Glu Glu Glu Glu 
    770                 775                 780                 


Asp Lys Leu Leu Ala Leu Lys Asp Phe Met Met Lys Ser Asn Lys Ala 
785                 790                 795                 800 


Lys Ala Asn Ile Val Asp Gln Ser His Leu His Asp Ser Ser Gln Lys 
                805                 810                 815     


Gly Val Ile Asp Leu Ala Ala Leu Gly Ile Thr Gly Arg Gln Val Asp 
            820                 825                 830         


Leu Val Lys Thr Lys Gln Glu Pro Asp Asp Lys Arg Ala Arg Lys His 
        835                 840                 845             


Val Lys Gln Asp Ser Asn Val Asn Glu Glu Trp Lys Ser Met Phe Gly 
    850                 855                 860                 


Ser Leu Asp Pro Pro Asn Met Pro Gln Ala Leu Pro Lys Gly Ser Asp 
865                 870                 875                 880 


Gln Glu Val Ile Gln Thr Gly Lys Pro Pro Arg Ser Glu Ser Ser Ala 
                885                 890                 895     


Gly Ile Cys Val Pro Leu Ser Thr Ser Ser Gln Val Pro Glu Val Thr 
            900                 905                 910         


Thr Val Gln Asn Lys Lys Pro Val Ile Pro Val Leu Ser Ser Thr Ile 
        915                 920                 925             


Leu Pro Ser Thr Tyr Gln Ile Arg Ile Thr Thr Cys Lys Thr Glu Leu 
    930                 935                 940                 


Gln Gln Leu Ile Gln Gln Lys Arg Glu Gln Cys Asn Ala Glu Arg Ile 
945                 950                 955                 960 


Ala Lys Gln Met Met Glu Asn Ala Glu Trp Glu Ser Lys Pro Pro Pro 
                965                 970                 975     


Pro Gly Trp Arg Pro Lys Gly Leu Leu Val Ala His Leu His Glu His 
            980                 985                 990         


Lys Ser Ala Val Asn Arg Ile Arg  Val Ser Asp Glu His  Ser Leu Phe 
        995                 1000                 1005             


Ala Thr  Cys Ser Asn Asp Gly  Thr Val Lys Ile Trp  Asn Ser Gln 
    1010                 1015                 1020             


Lys Met  Glu Gly Lys Thr Thr  Thr Thr Arg Ser Ile  Leu Thr Tyr 
    1025                 1030                 1035             


Ser Arg  Ile Gly Gly Arg Val  Lys Thr Leu Thr Phe  Cys Gln Gly 
    1040                 1045                 1050             


Ser His  Tyr Leu Ala Ile Ala  Ser Asp Asn Gly Ala  Val Gln Leu 
    1055                 1060                 1065             


Leu Gly  Ile Glu Ala Ser Lys  Leu Pro Lys Ser Pro  Lys Ile His 
    1070                 1075                 1080             


Pro Leu  Gln Ser Arg Ile Leu  Asp Gln Lys Glu Asp  Gly Cys Val 
    1085                 1090                 1095             


Val Asp  Met His His Phe Asn  Ser Gly Ala Gln Ser  Val Leu Ala 
    1100                 1105                 1110             


Tyr Ala  Thr Val Asn Gly Ser  Leu Val Gly Trp Asp  Leu Arg Ser 
    1115                 1120                 1125             


Ser Ser  Asn Ala Trp Thr Leu  Lys His Asp Leu Lys  Ser Gly Leu 
    1130                 1135                 1140             


Ile Thr  Ser Phe Ala Val Asp  Ile His Gln Cys Trp  Leu Cys Ile 
    1145                 1150                 1155             


Gly Thr  Ser Ser Gly Thr Met  Ala Cys Trp Asp Met  Arg Phe Gln 
    1160                 1165                 1170             


Leu Pro  Ile Ser Ser His Cys  His Pro Ser Arg Ala  Arg Ile Arg 
    1175                 1180                 1185             


Arg Leu  Ser Met His Pro Leu  Tyr Gln Ser Trp Val  Ile Ala Ala 
    1190                 1195                 1200             


Val Gln  Gly Asn Asn Glu Val  Ser Met Trp Asp Met  Glu Thr Gly 
    1205                 1210                 1215             


Asp Arg  Arg Phe Thr Leu Trp  Ala Ser Ser Ala Pro  Pro Leu Ser 
    1220                 1225                 1230             


Glu Leu  Gln Pro Ser Pro His  Ser Val His Gly Ile  Tyr Cys Ser 
    1235                 1240                 1245             


Pro Ala  Asp Gly Asn Pro Ile  Leu Leu Thr Ala Gly  Ser Asp Met 
    1250                 1255                 1260             


Lys Ile  Arg Phe Trp Asp Leu  Ala Tyr Pro Glu Arg  Ser Tyr Val 
    1265                 1270                 1275             


Val Ala  Gly Ser Thr Ser Ser  Pro Ser Val Ser Tyr  Tyr Arg Lys 
    1280                 1285                 1290             


Ile Ile  Glu Gly Thr Glu Val  Val Gln Glu Ile Gln  Asn Lys Gln 
    1295                 1300                 1305             


Lys Val  Gly Pro Ser Asp Asp  Thr Pro Arg Arg Gly  Pro Glu Ser 
    1310                 1315                 1320             


Leu Pro  Val Gly His His Asp  Ile Ile Thr Asp Val  Ala Thr Phe 
    1325                 1330                 1335             


Gln Thr  Thr Gln Gly Phe Ile  Val Thr Ala Ser Arg  Asp Gly Ile 
    1340                 1345                 1350             


Val Lys  Val Trp Lys 
    1355             


<210>  855
<211>  3389
<212>  DNA
<213>  Homosapiens

<400>  855
atgctgctgc taggggtggt gggagcagcc gtgggacgcg tggccgggag cgggggtgac     60

agcctgggat tccgggggct tctcttcctt gtcctcctcc tctcctctct attcccagtg    120

tggccgtggc tgacactaaa gactttgtag ccatcaaccc gagtgcagtt tcgatggaaa    180

atgaaggttg cacgttttca aaaaatacct aatggtgaaa atgagacaat gattcctgta    240

ttgacatcaa aaaaagcaag tgaattacca gtcagtgaag ttgcaagcat tctccaagct    300

gatcttcaga atggtctaaa caaatgtgaa gttagtcata ggcgagcctt tcatggctgg    360

aatgagtttg atattagtga agatgagcca ctgtggaaga agtatatttc tcagtttaaa    420

aatcccctta ttatgctgct tctggcttct gcagtcatca gtgttttaat gcatcagttt    480

gatgatgccg tcagtatcac tgtggcaata cttatcgttg ttacagttgc ctttgttcag    540

gaatatcgtt cagaaaaatc tcttgaagaa ttgagtaaac ttgtgccacc agaatgccat    600

tgtgtgcgtg aaggaaaatt ggagcataca cttgcccgag acttggttcc aggtgataca    660

gtttgccttt ctgttgggga tagagttcct gctgacttac gcttgtttga ggctgtggat    720

ctttccattg atgagtccag cttgacaggt gagacaacgc cttgttctaa ggtgacagct    780

cctcagccag ctgcaactaa tggagatctt gcatcgagaa gtaacattgc ctttatggga    840

acactggtca gatgtggcaa agcaaagggt gttgtcattg gaacaggaga aaattctgaa    900

tttggggagg tttttaaaat gatgcaagca gaagaggcac caaaaacccc tctgcagaag    960

agcatggacc tcttaggaaa acaactttcc ttttactcct ttggtataat aggaatcatc   1020

atgttggttg gctggttact gggaaaagat atcctggaaa tgtttactat tagtgtaagt   1080

ttggctgtag cagcaattcc tgaaggtctc cccattgtgg tcacagtgac gctagctctt   1140

ggtgttatga gaatggtgaa gaaaagggcc attgtgaaaa agctgcctat tgttgaaact   1200

ctgggctgct gtaatgtgat ttgttcagat aaaactggaa cactgacgaa gaatgaaatg   1260

actgttactc acatatttac ttcagatggt ctgcatgctg aggttactgg agttggctat   1320

aatcaatttg gggaagtgat tgttgatggt gatgttgttc atggattcta taacccagct   1380

gttagcagaa ttgttgaggc gggctgtgtg tgcaatgatg ctgtaattag aaacaatact   1440

ctaatgggga agccaacaga aggggcctta attgctcttg caatgaagat gggtcttgat   1500

ggacttcaac aagactacat cagaaaagct gaataccctt ttagctctga gcaaaagtgg   1560

atggctgtta agtgtgtaca ccgaacacag caggacagac cagagatttg ttttatgaaa   1620

ggtgcttacg aacaagtaat taagtactgt actacatacc agagcaaagg gcagaccttg   1680

acacttactc agcagcagag agatgtgtac caacaagaga aggcacgcat gggctcagcg   1740

ggactcagag ttcttgcttt ggcttctggt cctgaactgg gacagctgac atttcttggc   1800

ttggtgggaa tcattgatcc acctagaact ggtgtgaaag aagctgttac aacactcatt   1860

gcctcaggag tatcaataaa aatgattact ggagattcac aggagactgc agttgcaatc   1920

gccagtcgtc tgggattgta ttccaaaact tcccagtcag tctcaggaga agaaatagat   1980

gcaatggatg ttcagcagct ttcacaaata gtaccaaagg ttgcagtatt ttacagagct   2040

agcccaaggc acaagatgaa aattattaag tcgctacaga agaacggttc agttgtagcc   2100

atgacaggag atggagtaaa tgatgcagtt gctctgaagg ctgcagacat tggagttgcg   2160

atgggccaga ctggtacaga tgtttgcaaa gaggcagcag acatgatcct agtggatgat   2220

gattttcaaa ccataatgtc tgcaatcgaa gagggtaaag ggatttataa taacattaaa   2280

aatttcgtta gattccagct gagcacgagt atagcagcat taactttaat ctcattggct   2340

acattaatga actttcctaa tcctctcaat gccatgcaga ttttgtggat caatattatt   2400

atggatggac ccccagctca gagccttgga gtagaaccag tggataaaga tgtcattcgt   2460

aaacctcctc gcaactggaa agacagcatt ttgactaaaa acttgatact taaaatactt   2520

gtttcatcaa taatcattgt ttgtgggact ttgtttgtct tctggcgtga gctacgagac   2580

aatgtgatta cacctcgaga cacaacaatg accttcacat gctttgtgtt ttttgacatg   2640

ttcaatgcac taagttccag atcccagacc aagtctgtgt ttgagattgg actctgcagt   2700

aatagaatgt tttgctatgc agttcttgga tccatcatgg gacaattact agttatttac   2760

tttcctccgc ttcagaaggt ttttcagact gagagcctaa gcatactggg tctggctctg   2820

ggagaggagt ggacagcagc tggttgagat acatccccat ctggagacag gactgccact   2880

gacagaagat gtgagctgtg tctaagtcca gtcttgtgcc cagccgtgtc tgcgccttca   2940

ctctttggaa ctctgcatac aacatcttag caccatcttc ctgcagctct tccttaccta   3000

aataaagaaa cagcccaagg gcagtatttc taaaagcact gtaacagctt ttcattttct   3060

ccacatatac tacaaattct ataaagaaag aaattaattt aaaaaaacta agatgttttt   3120

ctcttctggc ttcataaatg ccttgctgta taaattgaaa tattgatact gaactgtctt   3180

tttaatgatg acctaacttt attcaaccca tcggaattta ctttttccct gaaataagat   3240

cttttccact ggtctactac ctgaccataa acatgtctgc atttgaattc tctaaaccct   3300

aaatctgtgt ctatgaaaaa tacaaatgac tattaaatat tattctcttt actgttctct   3360

ttcaccgaaa aaaaaaaaaa aaaaaaaaa                                     3389


<210>  856
<211>  888
<212>  PRT
<213>  Homosapiens

<400>  856

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Gly Leu Ala Leu 
865                 870                 875                 880 


Gly Glu Glu Trp Thr Ala Ala Gly 
                885             


<210>  857
<211>  3514
<212>  DNA
<213>  Homosapiens

<400>  857
atgctgctgc taggggtggt gggagcagcc gtgggacgcg tggccgggag cgggggtgac     60

agcctgggat tccgggggct tctcttcctt gtcctcctcc tctcctctct attcccagtg    120

tggccgtggc tgacactaaa gactttgtag ccatcaaccc gagtgcagtt tcgatggaaa    180

atgaaggttg cacgttttca aaaaatacct aatggtgaaa atgagacaat gattcctgta    240

ttgacatcaa aaaaagcaag tgaattacca gtcagtgaag ttgcaagcat tctccaagct    300

gatcttcaga atggtctaaa caaatgtgaa gttagtcata ggcgagcctt tcatggctgg    360

aatgagtttg atattagtga agatgagcca ctgtggaaga agtatatttc tcagtttaaa    420

aatcccctta ttatgctgct tctggcttct gcagtcatca gtgttttaat gcatcagttt    480

gatgatgccg tcagtatcac tgtggcaata cttatcgttg ttacagttgc ctttgttcag    540

gaatatcgtt cagaaaaatc tcttgaagaa ttgagtaaac ttgtgccacc agaatgccat    600

tgtgtgcgtg aaggaaaatt ggagcataca cttgcccgag acttggttcc aggtgataca    660

gtttgccttt ctgttgggga tagagttcct gctgacttac gcttgtttga ggctgtggat    720

ctttccattg atgagtccag cttgacaggt gagacaacgc cttgttctaa ggtgacagct    780

cctcagccag ctgcaactaa tggagatctt gcatcgagaa gtaacattgc ctttatggga    840

acactggtca gatgtggcaa agcaaagggt gttgtcattg gaacaggaga aaattctgaa    900

tttggggagg tttttaaaat gatgcaagca gaagaggcac caaaaacccc tctgcagaag    960

agcatggacc tcttaggaaa acaactttcc ttttactcct ttggtataat aggaatcatc   1020

atgttggttg gctggttact gggaaaagat atcctggaaa tgtttactat tagtgtaagt   1080

ttggctgtag cagcaattcc tgaaggtctc cccattgtgg tcacagtgac gctagctctt   1140

ggtgttatga gaatggtgaa gaaaagggcc attgtgaaaa agctgcctat tgttgaaact   1200

ctgggctgct gtaatgtgat ttgttcagat aaaactggaa cactgacgaa gaatgaaatg   1260

actgttactc acatatttac ttcagatggt ctgcatgctg aggttactgg agttggctat   1320

aatcaatttg gggaagtgat tgttgatggt gatgttgttc atggattcta taacccagct   1380

gttagcagaa ttgttgaggc gggctgtgtg tgcaatgatg ctgtaattag aaacaatact   1440

ctaatgggga agccaacaga aggggcctta attgctcttg caatgaagat gggtcttgat   1500

ggacttcaac aagactacat cagaaaagct gaataccctt ttagctctga gcaaaagtgg   1560

atggctgtta agtgtgtaca ccgaacacag caggacagac cagagatttg ttttatgaaa   1620

ggtgcttacg aacaagtaat taagtactgt actacatacc agagcaaagg gcagaccttg   1680

acacttactc agcagcagag agatgtgtac caacaagaga aggcacgcat gggctcagcg   1740

ggactcagag ttcttgcttt ggcttctggt cctgaactgg gacagctgac atttcttggc   1800

ttggtgggaa tcattgatcc acctagaact ggtgtgaaag aagctgttac aacactcatt   1860

gcctcaggag tatcaataaa aatgattact ggagattcac aggagactgc agttgcaatc   1920

gccagtcgtc tgggattgta ttccaaaact tcccagtcag tctcaggaga agaaatagat   1980

gcaatggatg ttcagcagct ttcacaaata gtaccaaagg ttgcagtatt ttacagagct   2040

agcccaaggc acaagatgaa aattattaag tcgctacaga agaacggttc agttgtagcc   2100

atgacaggag atggagtaaa tgatgcagtt gctctgaagg ctgcagacat tggagttgcg   2160

atgggccaga ctggtacaga tgtttgcaaa gaggcagcag acatgatcct agtggatgat   2220

gattttcaaa ccataatgtc tgcaatcgaa gagggtaaag ggatttataa taacattaaa   2280

aatttcgtta gattccagct gagcacgagt atagcagcat taactttaat ctcattggct   2340

acattaatga actttcctaa tcctctcaat gccatgcaga ttttgtggat caatattatt   2400

atggatggac ccccagctca gagccttgga gtagaaccag tggataaaga tgtcattcgt   2460

aaacctcctc gcaactggaa agacagcatt ttgactaaaa acttgatact taaaatactt   2520

gtttcatcaa taatcattgt ttgtgggact ttgtttgtct tctggcgtga gctacgagac   2580

aatgtgatta cacctcgaga cacaacaatg accttcacat gctttgtgtt ttttgacatg   2640

ttcaatgcac taagttccag atcccagacc aagtctgtgt ttgagattgg actctgcagt   2700

aatagaatgt tttgctatgc agttcttgga tccatcatgg gacaattact agttatttac   2760

tttcctccgc ttcagaaggt ttttcagact gagagcctaa gcatactgga tctgttgttt   2820

cttttgggtc tcacctcatc agtgtgcata gtggcagaaa ttataaagaa ggttgaaagg   2880

agcagggaaa agatccagaa gcatgttagt tcgacatcat catcttttct tgaagtctgg   2940

ctctgggaga ggagtggaca gcagctggtt gagatacatc cccatctgga gacaggactg   3000

ccactgacag aagatgtgag ctgtgtctaa gtccagtctt gtgcccagcc gtgtctgcgc   3060

cttcactctt tggaactctg catacaacat cttagcacca tcttcctgca gctcttcctt   3120

acctaaataa agaaacagcc caagggcagt atttctaaaa gcactgtaac agcttttcat   3180

tttctccaca tatactacaa attctataaa gaaagaaatt aatttaaaaa aactaagatg   3240

tttttctctt ctggcttcat aaatgccttg ctgtataaat tgaaatattg atactgaact   3300

gtctttttaa tgatgaccta actttattca acccatcgga atttactttt tccctgaaat   3360

aagatctttt ccactggtct actacctgac cataaacatg tctgcatttg aattctctaa   3420

accctaaatc tgtgtctatg aaaaatacaa atgactatta aatattattc tctttactgt   3480

tctctttcac cgaaaaaaaa aaaaaaaaaa aaaa                               3514


<210>  858
<211>  949
<212>  PRT
<213>  Homosapiens

<400>  858

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val Trp Leu Trp Glu Arg Ser Gly Gln Gln 
        915                 920                 925             


Leu Val Glu Ile His Pro His Leu Glu Thr Gly Leu Pro Leu Thr Glu 
    930                 935                 940                 


Asp Val Ser Cys Val 
945                 


<210>  859
<211>  3484
<212>  DNA
<213>  Homosapiens

<400>  859
atgctgctgc taggggtggt gggagcagcc gtgggacgcg tggccgggag cgggggtgac     60

agcctgggat tccgggggct tctcttcctt gtcctcctcc tctcctctct attcccagtg    120

tggccgtggc tgacactaaa gactttgtag ccatcaaccc gagtgcagtt tcgatggaaa    180

atgaaggttg cacgttttca aaaaatacct aatggtgaaa atgagacaat gattcctgta    240

ttgacatcaa aaaaagcaag tgaattacca gtcagtgaag ttgcaagcat tctccaagct    300

gatcttcaga atggtctaaa caaatgtgaa gttagtcata ggcgagcctt tcatggctgg    360

aatgagtttg atattagtga agatgagcca ctgtggaaga agtatatttc tcagtttaaa    420

aatcccctta ttatgctgct tctggcttct gcagtcatca gtgttttaat gcatcagttt    480

gatgatgccg tcagtatcac tgtggcaata cttatcgttg ttacagttgc ctttgttcag    540

gaatatcgtt cagaaaaatc tcttgaagaa ttgagtaaac ttgtgccacc agaatgccat    600

tgtgtgcgtg aaggaaaatt ggagcataca cttgcccgag acttggttcc aggtgataca    660

gtttgccttt ctgttgggga tagagttcct gctgacttac gcttgtttga ggctgtggat    720

ctttccattg atgagtccag cttgacaggt gagacaacgc cttgttctaa ggtgacagct    780

cctcagccag ctgcaactaa tggagatctt gcatcgagaa gtaacattgc ctttatggga    840

acactggtca gatgtggcaa agcaaagggt gttgtcattg gaacaggaga aaattctgaa    900

tttggggagg tttttaaaat gatgcaagca gaagaggcac caaaaacccc tctgcagaag    960

agcatggacc tcttaggaaa acaactttcc ttttactcct ttggtataat aggaatcatc   1020

atgttggttg gctggttact gggaaaagat atcctggaaa tgtttactat tagtgtaagt   1080

ttggctgtag cagcaattcc tgaaggtctc cccattgtgg tcacagtgac gctagctctt   1140

ggtgttatga gaatggtgaa gaaaagggcc attgtgaaaa agctgcctat tgttgaaact   1200

ctgggctgct gtaatgtgat ttgttcagat aaaactggaa cactgacgaa gaatgaaatg   1260

actgttactc acatatttac ttcagatggt ctgcatgctg aggttactgg agttggctat   1320

aatcaatttg gggaagtgat tgttgatggt gatgttgttc atggattcta taacccagct   1380

gttagcagaa ttgttgaggc gggctgtgtg tgcaatgatg ctgtaattag aaacaatact   1440

ctaatgggga agccaacaga aggggcctta attgctcttg caatgaagat gggtcttgat   1500

ggacttcaac aagactacat cagaaaagct gaataccctt ttagctctga gcaaaagtgg   1560

atggctgtta agtgtgtaca ccgaacacag caggacagac cagagatttg ttttatgaaa   1620

ggtgcttacg aacaagtaat taagtactgt actacatacc agagcaaagg gcagaccttg   1680

acacttactc agcagcagag agatgtgtac caacaagaga aggcacgcat gggctcagcg   1740

ggactcagag ttcttgcttt ggcttctggt cctgaactgg gacagctgac atttcttggc   1800

ttggtgggaa tcattgatcc acctagaact ggtgtgaaag aagctgttac aacactcatt   1860

gcctcaggag tatcaataaa aatgattact ggagattcac aggagactgc agttgcaatc   1920

gccagtcgtc tgggattgta ttccaaaact tcccagtcag tctcaggaga agaaatagat   1980

gcaatggatg ttcagcagct ttcacaaata gtaccaaagg ttgcagtatt ttacagagct   2040

agcccaaggc acaagatgaa aattattaag tcgctacaga agaacggttc agttgtagcc   2100

atgacaggag atggagtaaa tgatgcagtt gctctgaagg ctgcagacat tggagttgcg   2160

atgggccaga ctggtacaga tgtttgcaaa gaggcagcag acatgatcct agtggatgat   2220

gattttcaaa ccataatgtc tgcaatcgaa gagggtaaag ggatttataa taacattaaa   2280

aatttcgtta gattccagct gagcacgagt atagcagcat taactttaat ctcattggct   2340

acattaatga actttcctaa tcctctcaat gccatgcaga ttttgtggat caatattatt   2400

atggatggac ccccagctca gagccttgga gtagaaccag tggataaaga tgtcattcgt   2460

aaacctcctc gcaactggaa agacagcatt ttgactaaaa acttgatact taaaatactt   2520

gtttcatcaa taatcattgt ttgtgggact ttgtttgtct tctggcgtga gctacgagac   2580

aatgtgatta cacctcgaga cacaacaatg accttcacat gctttgtgtt ttttgacatg   2640

ttcaatgcac taagttccag atcccagacc aagtctgtgt ttgagattgg actctgcagt   2700

aatagaatgt tttgctatgc agttcttgga tccatcatgg gacaattact agttatttac   2760

tttcctccgc ttcagaaggt ttttcagact gagagcctaa gcatactgga tctgttgttt   2820

cttttgggtc tcacctcatc agtgtgcata gtggcagaaa ttataaagaa ggttgaaagg   2880

agcagggaaa agatccagaa gcatgtctgg ctctgggaga ggagtggaca gcagctggtt   2940

gagatacatc cccatctgga gacaggactg ccactgacag aagatgtgag ctgtgtctaa   3000

gtccagtctt gtgcccagcc gtgtctgcgc cttcactctt tggaactctg catacaacat   3060

cttagcacca tcttcctgca gctcttcctt acctaaataa agaaacagcc caagggcagt   3120

atttctaaaa gcactgtaac agcttttcat tttctccaca tatactacaa attctataaa   3180

gaaagaaatt aatttaaaaa aactaagatg tttttctctt ctggcttcat aaatgccttg   3240

ctgtataaat tgaaatattg atactgaact gtctttttaa tgatgaccta actttattca   3300

acccatcgga atttactttt tccctgaaat aagatctttt ccactggtct actacctgac   3360

cataaacatg tctgcatttg aattctctaa accctaaatc tgtgtctatg aaaaatacaa   3420

atgactatta aatattattc tctttactgt tctctttcac cgaaaaaaaa aaaaaaaaaa   3480

aaaa                                                                3484


<210>  860
<211>  939
<212>  PRT
<213>  Homosapiens

<400>  860

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Trp Leu Trp 
            900                 905                 910         


Glu Arg Ser Gly Gln Gln Leu Val Glu Ile His Pro His Leu Glu Thr 
        915                 920                 925             


Gly Leu Pro Leu Thr Glu Asp Val Ser Cys Val 
    930                 935                 


<210>  861
<211>  4753
<212>  DNA
<213>  Homosapiens

<400>  861
atgctgctgc taggggtggt gggagcagcc gtgggacgcg tggccgggag cgggggtgac     60

agcctgggat tccgggggct tctcttcctt gtcctcctcc tctcctctct attcccagtg    120

tggccgtggc tgacactaaa gactttgtag ccatcaaccc gagtgcagtt tcgatggaaa    180

atgaaggttg cacgttttca aaaaatacct aatggtgaaa atgagacaat gattcctgta    240

ttgacatcaa aaaaagcaag tgaattacca gtcagtgaag ttgcaagcat tctccaagct    300

gatcttcaga atggtctaaa caaatgtgaa gttagtcata ggcgagcctt tcatggctgg    360

aatgagtttg atattagtga agatgagcca ctgtggaaga agtatatttc tcagtttaaa    420

aatcccctta ttatgctgct tctggcttct gcagtcatca gtgttttaat gcatcagttt    480

gatgatgccg tcagtatcac tgtggcaata cttatcgttg ttacagttgc ctttgttcag    540

gaatatcgtt cagaaaaatc tcttgaagaa ttgagtaaac ttgtgccacc agaatgccat    600

tgtgtgcgtg aaggaaaatt ggagcataca cttgcccgag acttggttcc aggtgataca    660

gtttgccttt ctgttgggga tagagttcct gctgacttac gcttgtttga ggctgtggat    720

ctttccattg atgagtccag cttgacaggt gagacaacgc cttgttctaa ggtgacagct    780

cctcagccag ctgcaactaa tggagatctt gcatcgagaa gtaacattgc ctttatggga    840

acactggtca gatgtggcaa agcaaagggt gttgtcattg gaacaggaga aaattctgaa    900

tttggggagg tttttaaaat gatgcaagca gaagaggcac caaaaacccc tctgcagaag    960

agcatggacc tcttaggaaa acaactttcc ttttactcct ttggtataat aggaatcatc   1020

atgttggttg gctggttact gggaaaagat atcctggaaa tgtttactat tagtgtaagt   1080

ttggctgtag cagcaattcc tgaaggtctc cccattgtgg tcacagtgac gctagctctt   1140

ggtgttatga gaatggtgaa gaaaagggcc attgtgaaaa agctgcctat tgttgaaact   1200

ctgggctgct gtaatgtgat ttgttcagat aaaactggaa cactgacgaa gaatgaaatg   1260

actgttactc acatatttac ttcagatggt ctgcatgctg aggttactgg agttggctat   1320

aatcaatttg gggaagtgat tgttgatggt gatgttgttc atggattcta taacccagct   1380

gttagcagaa ttgttgaggc gggctgtgtg tgcaatgatg ctgtaattag aaacaatact   1440

ctaatgggga agccaacaga aggggcctta attgctcttg caatgaagat gggtcttgat   1500

ggacttcaac aagactacat cagaaaagct gaataccctt ttagctctga gcaaaagtgg   1560

atggctgtta agtgtgtaca ccgaacacag caggacagac cagagatttg ttttatgaaa   1620

ggtgcttacg aacaagtaat taagtactgt actacatacc agagcaaagg gcagaccttg   1680

acacttactc agcagcagag agatgtgtac caacaagaga aggcacgcat gggctcagcg   1740

ggactcagag ttcttgcttt ggcttctggt cctgaactgg gacagctgac atttcttggc   1800

ttggtgggaa tcattgatcc acctagaact ggtgtgaaag aagctgttac aacactcatt   1860

gcctcaggag tatcaataaa aatgattact ggagattcac aggagactgc agttgcaatc   1920

gccagtcgtc tgggattgta ttccaaaact tcccagtcag tctcaggaga agaaatagat   1980

gcaatggatg ttcagcagct ttcacaaata gtaccaaagg ttgcagtatt ttacagagct   2040

agcccaaggc acaagatgaa aattattaag tcgctacaga agaacggttc agttgtagcc   2100

atgacaggag atggagtaaa tgatgcagtt gctctgaagg ctgcagacat tggagttgcg   2160

atgggccaga ctggtacaga tgtttgcaaa gaggcagcag acatgatcct agtggatgat   2220

gattttcaaa ccataatgtc tgcaatcgaa gagggtaaag ggatttataa taacattaaa   2280

aatttcgtta gattccagct gagcacgagt atagcagcat taactttaat ctcattggct   2340

acattaatga actttcctaa tcctctcaat gccatgcaga ttttgtggat caatattatt   2400

atggatggac ccccagctca gagccttgga gtagaaccag tggataaaga tgtcattcgt   2460

aaacctcctc gcaactggaa agacagcatt ttgactaaaa acttgatact taaaatactt   2520

gtttcatcaa taatcattgt ttgtgggact ttgtttgtct tctggcgtga gctacgagac   2580

aatgtgatta cacctcgaga cacaacaatg accttcacat gctttgtgtt ttttgacatg   2640

ttcaatgcac taagttccag atcccagacc aagtctgtgt ttgagattgg actctgcagt   2700

aatagaatgt tttgctatgc agttcttgga tccatcatgg gacaattact agttatttac   2760

tttcctccgc ttcagaaggt ttttcagact gagagcctaa gcatactgga tctgttgttt   2820

cttttgggtc tcacctcatc agtgtgcata gtggcagaaa ttataaagaa ggttgaaagg   2880

agcagggaaa agatccagaa gcatgttagt tcgacatcat catcttttct tgaagtatga   2940

tgcatattgc attattttat ttgcaaacta ggaattgcag tctgaggatc atttagaagg   3000

gcaagttcaa gaggatatga agatttgaga actttttaac tattcattga ctaaaaatga   3060

acattaatgt taaagactta agactttaac ctgctggcag tcccaaatga aattatgcaa   3120

ctttgatatc atattccttg atttaaattg gcttttgtga ttgagtgaaa ctttataaag   3180

catatggtca gttatttaat taaaaaggca aaacctgaac caccttctgc acttaaagaa   3240

gtctaacagt acaaatacac tatctatctt agatagatat attttttttt atttttaaat   3300

attgtactat ttatggtggt ggggctttct tactaataca caaataaatt taatcatttc   3360

aaaggcattc tatttggttt agaagttgat tcccaggagt gccatatttc agctactgta   3420

tttccttttt cttgtaatgt aagcagctca gataccatgt gctatcattt ttgtatcaag   3480

ttttttgcac aggatgtgac cactgtcaga tcactgttct tttctttctt tttgtgattg   3540

aaaagcctat actacaattt gaagtaaatt tttgtttttc ttagtaagtg taaatggttg   3600

ctttattttt attttaaaaa ggtatgtctt tggtttggca gaattcatgc agggctatca   3660

agtggtgttc tagggtaaca gtgtccataa ttaacgctta gtcatagagt caaaaacatt   3720

taagactgat tgggttgaag tttataataa attatattaa catgtcttcc tttttgaggt   3780

aaagatatat actttgtcaa atatcatttt gtcatcctct aaatataaat ccaaatacct   3840

cagctaagta attctatttt attattttta ctgttatgta tgtttttaat catatttctt   3900

aggaagtata ggctactgga cttagaataa aaagtcccca aacccaaaca aatggtttat   3960

gaaccagagt atatgtggaa gattctttgc tggtcttgct ctgtgtgcat ctgaagcttc   4020

tttggcctag attttagcac aaacctgagt atatctcttc tactttcatc atgtgttctg   4080

taccttcttt ttgtttcatt gggcatgcta gggaaatagg tggattttgt gtgtaatgcc   4140

atcagttttt atgaaagctt gatgaggtat aggtcatttg ttttgagtat gtgggccaga   4200

aatttaaaat tagaaatttg tttttctgtt gagtatataa acaaaaattg gtcccaattc   4260

taacaggttt aatccttctt gaagccaata agttttatct tttataatct gtcaggatga   4320

accactcctt agcttttatc caatattaaa ctgcaagtgt tagcactgaa atattgtcat   4380

tgatagggaa aatatctatt ctttgagtca ttgttactga ggcagttgag tgtaaggagc   4440

tggctgcagt ttattctact taacccttta aggctgaatt gtcaaatgta cattgttcca   4500

tgtcgttaga tggaacatgg aagccattgt ctaatcaact ctatcattag tgacttgatg   4560

tctcatacct taattttgta atgattttta ttctctgtta caaagacttg aaatacgtat   4620

taaatgcacg ttaatgtttt gctttgcatt ttaggttcag attatgactt gattgaaata   4680

aatgtgccta tacattcatt tgctttgtac tataaaaata aaaatgattt cttaagttaa   4740

aaaaaaaaaa aaa                                                      4753


<210>  862
<211>  919
<212>  PRT
<213>  Homosapiens

<400>  862

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val 
        915                 


<210>  863
<211>  2662
<212>  DNA
<213>  Homosapiens

<400>  863
aagtaggcgg agaaagcaga ggaggaccgg cgggccaagc tttcctagcc tgacagcagc     60

catttcggaa cgtacgtccc agccctcttt agctacttag cgcctctggg cccgagaaca    120

cctgctcctt ggctcagtct ggcgccaccg gcatcacgga actgtacttc ccagagacgt    180

cacaccggga gacttccgat tcccgctctt gagattggac tctcacgtgc aggagccagt    240

cctcgctggg ctctagcggg cttctgatgg aggagctact cctctgggag gacagaaatt    300

agcagcagcc tctgtcacca tccaaagatt acaacccatg aaaccattga atttgtgcct    360

tgtatcagaa agcaaaggag aatgaaaaag cacagctaac attgcttgag gatctaggcg    420

attaattctt tagactgtca tcatgggtat ccgaggacta atgagttttg tggaagatca    480

tagtaatgaa ttcttcactg atttgaagtt gcgggacaca aaaattgtca ttgatggtta    540

tgctcttttc caccgtcttt gcttcagttc aaacttggat ctccggtatg gaggggacta    600

tgattctttt gcagatgttg tacaaaaatt ctttgaatca ctgtttgctt gtaatatatg    660

cccatatgtt gtattagatg gaggatgtga catttcagat aaaaagctta caactttaaa    720

ggatagagct agagagaaga tccagatggc ccattccctt tctgttggtg ggagtgggta    780

cgtatgtccc ttactcatcc gggaagtatt catacaggtt ttgatcaagc tgcgggtgtg    840

ttttgtccag tgcttttcag aagcagatcg ggacattatg acacttgcta accattggaa    900

ttgccctgtg ttatcatcag atagtgactt ttgcattttt gacctgaaaa ctgggttttg    960

cccattgaat agctttcagt ggagaaatat gaacactatt aagggcacac aaaactatat   1020

ccctgccaaa tgcttttccc ttgatgcatt ctgccatcac ttcagcaata tgaataaagc   1080

tctactacct ctctttgcgg tgctatgtgg aaatgaccat gttaatctac ccatcatgga   1140

gacattctta agtaaagcgc gtcttcctct tggagctacc agttctaaag ggaggagaca   1200

ccaccgaatc ctgggacttc tgaattggtt gtctcatttt gccaacccta ccgaagcact   1260

agataatgtt ctgaaatacc tcccaaaaaa ggatcgagaa aatgttaagg aacttctctg   1320

ctgttccatg gaagaatacc aacagtccca ggtgaagcta caggacttct tccagtgtgg   1380

tacttatgtc tgtccagatg ccttgaatct tggtttacca gaatgggtat tagtggcttt   1440

agctaaaggc cagctatctc ctttcatcag tgatgctttg gtcctaagac ggaccattct   1500

tcccacacag gtggaaaaca tgcagcaacc aaatgcccac agaatatctc agcccatcag   1560

gcaaatcatc tatgggcttc ttttaaatgc ctcaccacat ctggacaaga catcctggaa   1620

tgcattgcct cctcagcctc tagctttcag tgaagtggaa aggattaata aaaatatcag   1680

aacctcaatc attgatgcag tagaactggc caaggatcat tctgacttaa gcagattgac   1740

tgagctctcc ttgaggaggc ggcagatgct tctgttagaa accctgaagg tgaaacagac   1800

cattctggag ccaatcccta cttcactgaa gttgcccatt gctgtcagtt gctactggtt   1860

gcagcacacc gagaccaaag caaagctaca tcatctacaa tccttactgc tcacaatgct   1920

agtggggccc ttgattgcca taatcaacag ccctggtaag gaagagctgc aggaagatgg   1980

tgctaagatg ttgtatgcag agttccaaag agtgaaggcg cagacacggc tgggcacaag   2040

actggactta gacacagctc acatcttctg tcagtggcag tcctgtctcc agatggggat   2100

gtatctcaac cagctgctgt ccactcctct cccagagcca gacctaactc gactgtacag   2160

tggaagcctg gtgcacggac tatgccagca actgctagca tcgacctctg tagaaagtct   2220

cctgagcata tgtcctgagg ctaagcaact ttatgaatat ctattcaatg ccacaaggtc   2280

atatgccccc gctgaaatat tcctaccaaa aggtagatca aattcaaaaa aaaaaaggca   2340

gaagaaacag aataccagct gttctaagaa cagagggaga accactgcac acaccaagtg   2400

ttggtatgag ggaaacaacc ggtttgggtt gttaatggtt gaaaacttag aggaacatag   2460

tgaggcctcc aacattgaat aaaactcagt ttgcatcaaa ctagatgtat ttaatataat   2520

ccttacttaa aattcttccg ttaccaccct tgaaacaatt agctttttct ttaggactga   2580

cctgttaggg gataaacatc acaataatct gaattccaag ttattttgta ttttgttttt   2640

aataaataca acctgattta ag                                            2662


<210>  864
<211>  679
<212>  PRT
<213>  Homosapiens

<400>  864

Met Gly Ile Arg Gly Leu Met Ser Phe Val Glu Asp His Ser Asn Glu 
1               5                   10                  15      


Phe Phe Thr Asp Leu Lys Leu Arg Asp Thr Lys Ile Val Ile Asp Gly 
            20                  25                  30          


Tyr Ala Leu Phe His Arg Leu Cys Phe Ser Ser Asn Leu Asp Leu Arg 
        35                  40                  45              


Tyr Gly Gly Asp Tyr Asp Ser Phe Ala Asp Val Val Gln Lys Phe Phe 
    50                  55                  60                  


Glu Ser Leu Phe Ala Cys Asn Ile Cys Pro Tyr Val Val Leu Asp Gly 
65                  70                  75                  80  


Gly Cys Asp Ile Ser Asp Lys Lys Leu Thr Thr Leu Lys Asp Arg Ala 
                85                  90                  95      


Arg Glu Lys Ile Gln Met Ala His Ser Leu Ser Val Gly Gly Ser Gly 
            100                 105                 110         


Tyr Val Cys Pro Leu Leu Ile Arg Glu Val Phe Ile Gln Val Leu Ile 
        115                 120                 125             


Lys Leu Arg Val Cys Phe Val Gln Cys Phe Ser Glu Ala Asp Arg Asp 
    130                 135                 140                 


Ile Met Thr Leu Ala Asn His Trp Asn Cys Pro Val Leu Ser Ser Asp 
145                 150                 155                 160 


Ser Asp Phe Cys Ile Phe Asp Leu Lys Thr Gly Phe Cys Pro Leu Asn 
                165                 170                 175     


Ser Phe Gln Trp Arg Asn Met Asn Thr Ile Lys Gly Thr Gln Asn Tyr 
            180                 185                 190         


Ile Pro Ala Lys Cys Phe Ser Leu Asp Ala Phe Cys His His Phe Ser 
        195                 200                 205             


Asn Met Asn Lys Ala Leu Leu Pro Leu Phe Ala Val Leu Cys Gly Asn 
    210                 215                 220                 


Asp His Val Asn Leu Pro Ile Met Glu Thr Phe Leu Ser Lys Ala Arg 
225                 230                 235                 240 


Leu Pro Leu Gly Ala Thr Ser Ser Lys Gly Arg Arg His His Arg Ile 
                245                 250                 255     


Leu Gly Leu Leu Asn Trp Leu Ser His Phe Ala Asn Pro Thr Glu Ala 
            260                 265                 270         


Leu Asp Asn Val Leu Lys Tyr Leu Pro Lys Lys Asp Arg Glu Asn Val 
        275                 280                 285             


Lys Glu Leu Leu Cys Cys Ser Met Glu Glu Tyr Gln Gln Ser Gln Val 
    290                 295                 300                 


Lys Leu Gln Asp Phe Phe Gln Cys Gly Thr Tyr Val Cys Pro Asp Ala 
305                 310                 315                 320 


Leu Asn Leu Gly Leu Pro Glu Trp Val Leu Val Ala Leu Ala Lys Gly 
                325                 330                 335     


Gln Leu Ser Pro Phe Ile Ser Asp Ala Leu Val Leu Arg Arg Thr Ile 
            340                 345                 350         


Leu Pro Thr Gln Val Glu Asn Met Gln Gln Pro Asn Ala His Arg Ile 
        355                 360                 365             


Ser Gln Pro Ile Arg Gln Ile Ile Tyr Gly Leu Leu Leu Asn Ala Ser 
    370                 375                 380                 


Pro His Leu Asp Lys Thr Ser Trp Asn Ala Leu Pro Pro Gln Pro Leu 
385                 390                 395                 400 


Ala Phe Ser Glu Val Glu Arg Ile Asn Lys Asn Ile Arg Thr Ser Ile 
                405                 410                 415     


Ile Asp Ala Val Glu Leu Ala Lys Asp His Ser Asp Leu Ser Arg Leu 
            420                 425                 430         


Thr Glu Leu Ser Leu Arg Arg Arg Gln Met Leu Leu Leu Glu Thr Leu 
        435                 440                 445             


Lys Val Lys Gln Thr Ile Leu Glu Pro Ile Pro Thr Ser Leu Lys Leu 
    450                 455                 460                 


Pro Ile Ala Val Ser Cys Tyr Trp Leu Gln His Thr Glu Thr Lys Ala 
465                 470                 475                 480 


Lys Leu His His Leu Gln Ser Leu Leu Leu Thr Met Leu Val Gly Pro 
                485                 490                 495     


Leu Ile Ala Ile Ile Asn Ser Pro Gly Lys Glu Glu Leu Gln Glu Asp 
            500                 505                 510         


Gly Ala Lys Met Leu Tyr Ala Glu Phe Gln Arg Val Lys Ala Gln Thr 
        515                 520                 525             


Arg Leu Gly Thr Arg Leu Asp Leu Asp Thr Ala His Ile Phe Cys Gln 
    530                 535                 540                 


Trp Gln Ser Cys Leu Gln Met Gly Met Tyr Leu Asn Gln Leu Leu Ser 
545                 550                 555                 560 


Thr Pro Leu Pro Glu Pro Asp Leu Thr Arg Leu Tyr Ser Gly Ser Leu 
                565                 570                 575     


Val His Gly Leu Cys Gln Gln Leu Leu Ala Ser Thr Ser Val Glu Ser 
            580                 585                 590         


Leu Leu Ser Ile Cys Pro Glu Ala Lys Gln Leu Tyr Glu Tyr Leu Phe 
        595                 600                 605             


Asn Ala Thr Arg Ser Tyr Ala Pro Ala Glu Ile Phe Leu Pro Lys Gly 
    610                 615                 620                 


Arg Ser Asn Ser Lys Lys Lys Arg Gln Lys Lys Gln Asn Thr Ser Cys 
625                 630                 635                 640 


Ser Lys Asn Arg Gly Arg Thr Thr Ala His Thr Lys Cys Trp Tyr Glu 
                645                 650                 655     


Gly Asn Asn Arg Phe Gly Leu Leu Met Val Glu Asn Leu Glu Glu His 
            660                 665                 670         


Ser Glu Ala Ser Asn Ile Glu 
        675                 


<210>  865
<211>  2939
<212>  DNA
<213>  Homosapiens

<400>  865
ccaaacagcc gtggcccgcg gtgtctggcg ctcggtgggt gtggttgccc ctagtttgag     60

gcctgcccga ttacccgcaa gacttgggca gccccgggcg ccgctccgac cacgacaggg    120

aaaggaacct taatctcatc tttaaaataa ggagaattac tgagtgacct gaaggaccct    180

tttcagctgg aaagtctgaa ctgaccaaca ctggatgaat ttgaccattt cttaggagac    240

tggaatgtta agtttctata aatgaatgaa ccagttctct cttgtttgga gcaatgctga    300

aattccaaga ggcagctaag tgtgtgagtg gatcaacagc catttccact tatccaaaga    360

ccttgattgc aagaagatac gtgcttcaac aaaaacttgg cagtggaagt tttggaactg    420

tctatctggt ttcagacaag aaagccaaac gaggagagga attaaaggta cttaaggaaa    480

tatctgttgg agaactaaat ccaaatgaaa ctgtacaggc caatttggaa gcccaactcc    540

tctccaagct ggaccaccca gccattgtca agttccatgc aagttttgtg gagcaagata    600

atttctgcat tatcacggag tactgtgagg gccgagatct ggacgataaa attcaggaat    660

ataaacaagc tggaaaaatc tttccagaaa atcaaataat agaatggttt atccagctgc    720

tgctgggagt tgactacatg catgagagga ggatacttca tcgagactta aagtcaaaga    780

atgtatttct gaaaaataat ctccttaaaa ttggagattt tggagtttct cgacttctaa    840

tgggatcctg tgacctggcc acaactttaa ctggaactcc ccattatatg agtcctgagg    900

ctctgaaaca ccaaggctat gacacaaagt cggacatctg gtcactggca tgcattttgt    960

atgagatgtg ctgcatgaat catgcattcg ctggctccaa tttcttatcc attgttttaa   1020

aaattgttga aggtgacaca ccttctctcc ctgagagata tccaaaagaa ctaaatgcca   1080

tcatggaaag catgttgaac aagaatcctt cattaagacc atctgctatc gaaattttaa   1140

aaatccctta ccttgatgag cagctacaga acctaatgtg tagatattca gaaatgactc   1200

tggaagacaa aaatttggat tgtcagaagg aggctgctca tataattaat gccatgcaaa   1260

aaaggatcca cctgcagact ctgagggcac tgtcagaagt acagaaaatg acgccaagag   1320

aaaggatgcg gctgaggaag ctccaggcgg ctgatgagaa agccaggaag ctgaaaaaga   1380

ttgtggaaga aaaatatgaa gaaaatagca aacgaatgca agaattgaga tctcggaact   1440

ttcagcagct gagtgttgat gtactccatg aaaaaacaca tttaaaagga atggaagaaa   1500

aggaggagca acctgaggga agactttctt gttcacccca ggacgaggat gaagagaggt   1560

ggcaaggcag ggaagaggaa tctgatgaac caactttaga gaacctgcct gagtctcagc   1620

ctattccttc catggacctc cacgaacttg aatcaattgt agaggatgcc acatctgacc   1680

ttggatacca tgagatccca gaagacccac ttgtggctga agagtactac gctgatgcat   1740

ttgattccta ttgtgtagag agtgatgagg aggaagaaga aatagcgtta gaaagaccag   1800

agaaagaaat caggaatgag ggatcccagc ctgcttacag aacaaaccaa caggacagtg   1860

atatcgaagc gttggccagg tgtttggaaa atgtcctggg ttgcacttct ctagacacaa   1920

agaccatcac caccatggct gaagacatgt ccccaggacc accaattttc aacagtgtga   1980

tggccaggac caagatgaaa cgcatgaggg aatcagccat gcagaagctg gggacagaag   2040

tatttgaaga ggtctataat tacctcaaga gagcaaggca tcagaatgct agcgaagcag   2100

agatccgcga gtgtttggaa aaagtggtgc ctcaagccag cgactgtttt gaagtggacc   2160

agctcctgta ctttgaagag cagttgctga tcacgatggg aaaagaacct actctccaga   2220

accatctcta ggcaactatc aaaaagaagc agaagttcaa gtggacaaat ttatgtgaaa   2280

attcatttaa catataagct gaactctatt atggggaatg gatacaaaag cagagctccc   2340

atcttgactt tcaattcctc atcagaagta ctggcttctt tagagagtag taagcatggc   2400

tgcctatgct tggagtcata agtgttattt ggactatacc ctgagataag cttatagatc   2460

aagtttggct cccttgaaaa gcatttctct catgtgcgcc ctcagggctt ccagcaggat   2520

tgagtcaccc tgacgatgac cggggagaag ccgtgtgctc ttcattattt tcagctggag   2580

gacagagctc agtgcctgac tgcctagggt ctcatggact gtaggcagcc tgccagtgaa   2640

ggtcactgga ctctagccta caacatgctg agctacagcc cagaagccag acatgcctgt   2700

cttagctgac ctgtttttgg tccacttttg cccttccatg actaataagg aagatatgtg   2760

tgtatttcat acacacacaa ggacctggat taaaaatcca aaaagtgatt ctcttctatg   2820

atttatttca aactcatcca tagataattc aagatttgta ttcaaaataa acatagtttt   2880

cacagttaca aaataaatca cctattttat ctttagaaaa aaaaaaaaaa aaaaaaaaa    2939


<210>  866
<211>  645
<212>  PRT
<213>  Homosapiens

<400>  866

Met Leu Lys Phe Gln Glu Ala Ala Lys Cys Val Ser Gly Ser Thr Ala 
1               5                   10                  15      


Ile Ser Thr Tyr Pro Lys Thr Leu Ile Ala Arg Arg Tyr Val Leu Gln 
            20                  25                  30          


Gln Lys Leu Gly Ser Gly Ser Phe Gly Thr Val Tyr Leu Val Ser Asp 
        35                  40                  45              


Lys Lys Ala Lys Arg Gly Glu Glu Leu Lys Val Leu Lys Glu Ile Ser 
    50                  55                  60                  


Val Gly Glu Leu Asn Pro Asn Glu Thr Val Gln Ala Asn Leu Glu Ala 
65                  70                  75                  80  


Gln Leu Leu Ser Lys Leu Asp His Pro Ala Ile Val Lys Phe His Ala 
                85                  90                  95      


Ser Phe Val Glu Gln Asp Asn Phe Cys Ile Ile Thr Glu Tyr Cys Glu 
            100                 105                 110         


Gly Arg Asp Leu Asp Asp Lys Ile Gln Glu Tyr Lys Gln Ala Gly Lys 
        115                 120                 125             


Ile Phe Pro Glu Asn Gln Ile Ile Glu Trp Phe Ile Gln Leu Leu Leu 
    130                 135                 140                 


Gly Val Asp Tyr Met His Glu Arg Arg Ile Leu His Arg Asp Leu Lys 
145                 150                 155                 160 


Ser Lys Asn Val Phe Leu Lys Asn Asn Leu Leu Lys Ile Gly Asp Phe 
                165                 170                 175     


Gly Val Ser Arg Leu Leu Met Gly Ser Cys Asp Leu Ala Thr Thr Leu 
            180                 185                 190         


Thr Gly Thr Pro His Tyr Met Ser Pro Glu Ala Leu Lys His Gln Gly 
        195                 200                 205             


Tyr Asp Thr Lys Ser Asp Ile Trp Ser Leu Ala Cys Ile Leu Tyr Glu 
    210                 215                 220                 


Met Cys Cys Met Asn His Ala Phe Ala Gly Ser Asn Phe Leu Ser Ile 
225                 230                 235                 240 


Val Leu Lys Ile Val Glu Gly Asp Thr Pro Ser Leu Pro Glu Arg Tyr 
                245                 250                 255     


Pro Lys Glu Leu Asn Ala Ile Met Glu Ser Met Leu Asn Lys Asn Pro 
            260                 265                 270         


Ser Leu Arg Pro Ser Ala Ile Glu Ile Leu Lys Ile Pro Tyr Leu Asp 
        275                 280                 285             


Glu Gln Leu Gln Asn Leu Met Cys Arg Tyr Ser Glu Met Thr Leu Glu 
    290                 295                 300                 


Asp Lys Asn Leu Asp Cys Gln Lys Glu Ala Ala His Ile Ile Asn Ala 
305                 310                 315                 320 


Met Gln Lys Arg Ile His Leu Gln Thr Leu Arg Ala Leu Ser Glu Val 
                325                 330                 335     


Gln Lys Met Thr Pro Arg Glu Arg Met Arg Leu Arg Lys Leu Gln Ala 
            340                 345                 350         


Ala Asp Glu Lys Ala Arg Lys Leu Lys Lys Ile Val Glu Glu Lys Tyr 
        355                 360                 365             


Glu Glu Asn Ser Lys Arg Met Gln Glu Leu Arg Ser Arg Asn Phe Gln 
    370                 375                 380                 


Gln Leu Ser Val Asp Val Leu His Glu Lys Thr His Leu Lys Gly Met 
385                 390                 395                 400 


Glu Glu Lys Glu Glu Gln Pro Glu Gly Arg Leu Ser Cys Ser Pro Gln 
                405                 410                 415     


Asp Glu Asp Glu Glu Arg Trp Gln Gly Arg Glu Glu Glu Ser Asp Glu 
            420                 425                 430         


Pro Thr Leu Glu Asn Leu Pro Glu Ser Gln Pro Ile Pro Ser Met Asp 
        435                 440                 445             


Leu His Glu Leu Glu Ser Ile Val Glu Asp Ala Thr Ser Asp Leu Gly 
    450                 455                 460                 


Tyr His Glu Ile Pro Glu Asp Pro Leu Val Ala Glu Glu Tyr Tyr Ala 
465                 470                 475                 480 


Asp Ala Phe Asp Ser Tyr Cys Val Glu Ser Asp Glu Glu Glu Glu Glu 
                485                 490                 495     


Ile Ala Leu Glu Arg Pro Glu Lys Glu Ile Arg Asn Glu Gly Ser Gln 
            500                 505                 510         


Pro Ala Tyr Arg Thr Asn Gln Gln Asp Ser Asp Ile Glu Ala Leu Ala 
        515                 520                 525             


Arg Cys Leu Glu Asn Val Leu Gly Cys Thr Ser Leu Asp Thr Lys Thr 
    530                 535                 540                 


Ile Thr Thr Met Ala Glu Asp Met Ser Pro Gly Pro Pro Ile Phe Asn 
545                 550                 555                 560 


Ser Val Met Ala Arg Thr Lys Met Lys Arg Met Arg Glu Ser Ala Met 
                565                 570                 575     


Gln Lys Leu Gly Thr Glu Val Phe Glu Glu Val Tyr Asn Tyr Leu Lys 
            580                 585                 590         


Arg Ala Arg His Gln Asn Ala Ser Glu Ala Glu Ile Arg Glu Cys Leu 
        595                 600                 605             


Glu Lys Val Val Pro Gln Ala Ser Asp Cys Phe Glu Val Asp Gln Leu 
    610                 615                 620                 


Leu Tyr Phe Glu Glu Gln Leu Leu Ile Thr Met Gly Lys Glu Pro Thr 
625                 630                 635                 640 


Leu Gln Asn His Leu 
                645 


<210>  867
<211>  2080
<212>  DNA
<213>  Homosapiens

<400>  867
ccaaacagcc gtggcccgcg gtgtctggcg ctcggtgggt gtggttgccc ctagtttgag     60

gcctgcccga ttacccgcaa gacttgggca gccccgggcg ccgctccgac cacgacaggg    120

aaaggaacct taatctcatc tttaaaataa ggagaattac tgagtgacct gaaggaccct    180

tttcagctgg aaagtctgaa ctgaccaaca ctggatgaat ttgaccattt cttaggagac    240

tggaatgtta agtttctata aatgaatgaa ccagttctct cttgtttgga gcaatgctga    300

aattccaaga ggcagctaag tgtgtgagtg gatcaacagc catttccact tatccaaaga    360

ccttgattgc aagaagatac gtgcttcaac aaaaacttgg cagtggaagt tttggaactg    420

tctatctggt ttcagacaag aaagccaaac gaggagagga attaaaggta cttaaggaaa    480

tatctgttgg agaactaaat ccaaatgaaa ctgtacaggc caatttggaa gcccaactcc    540

tctccaagct ggaccaccca gccattgtca agttccatgc aagttttgtg gagcaagata    600

atttctgcat tatcacggag tactgtgagg gccgagatct ggacgataaa attcaggaat    660

ataaacaagc tggaaaaatc tttccagaaa atcaaataat agaatggttt atccagctgc    720

tgctgggagt tgactacatg catgagagga ggatacttca tcgagactta aagtcaaaga    780

atgtatttct gaaaaataat ctccttaaaa ttggagattt tggagtttct cgacttctaa    840

tgggatcctg tgacctggcc acaactttaa ctggaactcc ccattatatg agtcctgagg    900

ctctgaaaca ccaaggctat gacacaaagt cggacatctg gtcactggca tgcattttgt    960

atgagatgtg ctgcatgaat catgcattcg ctggctccaa tttcttatcc attgttttaa   1020

aaattgttga aggtgacaca ccttctctcc ctgagagata tccaaaagaa ctaaatgcca   1080

tcatggaaag catgttgaac aagaatcctt cattaagacc atctgctatc gaaattttaa   1140

aaatccctta ccttgatgag cagctacaga acctaatgtg tagatattca gaaatgactc   1200

tggaagacaa aaatttggat tgtcagaagg aggctgctca tataattaat gccatgcaaa   1260

aaaggatcca cctgcagact ctgagggcac tgtcagaagt acagaaaatg acgccaagag   1320

aaaggatgcg gctgaggaag ctccaggcgg ctgatgagaa agccaggaag ctgaaaaaga   1380

ttgtggaaga aaaatatgaa gaaaatagca aacgaatgca agaattgaga tctcggaact   1440

ttcagcagct gagtgttgat gtactccatg aaaaaacaca tttaaaagga atggaagaaa   1500

aggaggagca acctgaggga agactttctt gttcacccca ggacgaggat gaagagaggt   1560

ggcaaggcag ggaagaggaa tctgatgaac caactttaga gaacctgcct gagtctcagc   1620

ctattccttc catggacctc cacgaacttg aatcaattgt agaggatgcc acatctgacc   1680

ttggatacca tgcaactcac agctgacttt cagagcagtg ttttttccaa agctggaata   1740

gcctgagact ctagggcctg ggtctacaag gagcatgact ccctacccca ccattcagat   1800

gtggagaatg cagtgaagta ggccttggct gcttacccac atcctgacca gctgtcacct   1860

cttcatttcc tgttcagcca ctctttaagc aatcactgag cccaatgctc agagatagct   1920

cagacctgta ggtggttgtg ctttgcttgc ctgtaggagc cccacatgcc ctttacagtt   1980

ctgggctgtc tatgacttac gatatcacct cttcttttta aatgtccaag tggaaataaa   2040

gtgatttgaa ctttgccaaa aaaaaaaaaa aaaaaaaaaa                         2080


<210>  868
<211>  470
<212>  PRT
<213>  Homosapiens

<400>  868

Met Leu Lys Phe Gln Glu Ala Ala Lys Cys Val Ser Gly Ser Thr Ala 
1               5                   10                  15      


Ile Ser Thr Tyr Pro Lys Thr Leu Ile Ala Arg Arg Tyr Val Leu Gln 
            20                  25                  30          


Gln Lys Leu Gly Ser Gly Ser Phe Gly Thr Val Tyr Leu Val Ser Asp 
        35                  40                  45              


Lys Lys Ala Lys Arg Gly Glu Glu Leu Lys Val Leu Lys Glu Ile Ser 
    50                  55                  60                  


Val Gly Glu Leu Asn Pro Asn Glu Thr Val Gln Ala Asn Leu Glu Ala 
65                  70                  75                  80  


Gln Leu Leu Ser Lys Leu Asp His Pro Ala Ile Val Lys Phe His Ala 
                85                  90                  95      


Ser Phe Val Glu Gln Asp Asn Phe Cys Ile Ile Thr Glu Tyr Cys Glu 
            100                 105                 110         


Gly Arg Asp Leu Asp Asp Lys Ile Gln Glu Tyr Lys Gln Ala Gly Lys 
        115                 120                 125             


Ile Phe Pro Glu Asn Gln Ile Ile Glu Trp Phe Ile Gln Leu Leu Leu 
    130                 135                 140                 


Gly Val Asp Tyr Met His Glu Arg Arg Ile Leu His Arg Asp Leu Lys 
145                 150                 155                 160 


Ser Lys Asn Val Phe Leu Lys Asn Asn Leu Leu Lys Ile Gly Asp Phe 
                165                 170                 175     


Gly Val Ser Arg Leu Leu Met Gly Ser Cys Asp Leu Ala Thr Thr Leu 
            180                 185                 190         


Thr Gly Thr Pro His Tyr Met Ser Pro Glu Ala Leu Lys His Gln Gly 
        195                 200                 205             


Tyr Asp Thr Lys Ser Asp Ile Trp Ser Leu Ala Cys Ile Leu Tyr Glu 
    210                 215                 220                 


Met Cys Cys Met Asn His Ala Phe Ala Gly Ser Asn Phe Leu Ser Ile 
225                 230                 235                 240 


Val Leu Lys Ile Val Glu Gly Asp Thr Pro Ser Leu Pro Glu Arg Tyr 
                245                 250                 255     


Pro Lys Glu Leu Asn Ala Ile Met Glu Ser Met Leu Asn Lys Asn Pro 
            260                 265                 270         


Ser Leu Arg Pro Ser Ala Ile Glu Ile Leu Lys Ile Pro Tyr Leu Asp 
        275                 280                 285             


Glu Gln Leu Gln Asn Leu Met Cys Arg Tyr Ser Glu Met Thr Leu Glu 
    290                 295                 300                 


Asp Lys Asn Leu Asp Cys Gln Lys Glu Ala Ala His Ile Ile Asn Ala 
305                 310                 315                 320 


Met Gln Lys Arg Ile His Leu Gln Thr Leu Arg Ala Leu Ser Glu Val 
                325                 330                 335     


Gln Lys Met Thr Pro Arg Glu Arg Met Arg Leu Arg Lys Leu Gln Ala 
            340                 345                 350         


Ala Asp Glu Lys Ala Arg Lys Leu Lys Lys Ile Val Glu Glu Lys Tyr 
        355                 360                 365             


Glu Glu Asn Ser Lys Arg Met Gln Glu Leu Arg Ser Arg Asn Phe Gln 
    370                 375                 380                 


Gln Leu Ser Val Asp Val Leu His Glu Lys Thr His Leu Lys Gly Met 
385                 390                 395                 400 


Glu Glu Lys Glu Glu Gln Pro Glu Gly Arg Leu Ser Cys Ser Pro Gln 
                405                 410                 415     


Asp Glu Asp Glu Glu Arg Trp Gln Gly Arg Glu Glu Glu Ser Asp Glu 
            420                 425                 430         


Pro Thr Leu Glu Asn Leu Pro Glu Ser Gln Pro Ile Pro Ser Met Asp 
        435                 440                 445             


Leu His Glu Leu Glu Ser Ile Val Glu Asp Ala Thr Ser Asp Leu Gly 
    450                 455                 460                 


Tyr His Ala Thr His Ser 
465                 470 


<210>  869
<211>  3857
<212>  DNA
<213>  Homosapiens

<400>  869
gagagatcga ggtgacaggc gagctggctg gactcggagc gcggtcgagg ctttctgcgt     60

tcgcggcggc ggaatggccc gtgcgcggct cgccgcgtcg cggctctgtg gtccctagac    120

gtcggctccc gccctcggcg ctgatctccg gcgcgggcac tgctttccac tcggctcctg    180

tcgtccgttc tctcaggctc ccgttcagga tttttagact ctgaggagca gttggagcta    240

atccacatta tggaaatgga aaccaccgaa cctgagccag actgtgtagt gcagcctccc    300

tctcctcctg atgacttttc atgccaaatg agactctctg agaagatcac tccattgaag    360

acttgtttta agaaaaagga tcagaaaaga ttgggaactg gaaccctgag gtctttgagg    420

ccaatattaa acactcttct agaatctggc tcacttgatg gggtttttag atctaggaac    480

cagagtacag atgagaacag cttacatgaa cctatgatga agaaagccat ggaaatcaat    540

tcatcatgcc caccagcaga aaataatatg tctgttctga ttcctgatag gacaaatgtt    600

ggggaccaga taccggaagc ccatccttcc actgaagctc cagaacgagt ggttccaatc    660

caagatcaca gctttccatc agaaaccctc agtgggacgg tggcagattc cacaccagct    720

cacttccaga ctgatctttt gcacccagtt tcaagtgatg ttcctactag tcctgactgc    780

ttagacaaag tcatagatta tgttccaggc attttccaag aaaacagttt tacaatccaa    840

tacattctgg acaccagtga taagctgagt actgagctct ttcaggacaa aagtgaagag    900

gcttcccttg acctcgtgtt tgagctggtg aaccagttgc agtaccacac tcaccaagag    960

aacggaattg aaatttgcat ggactttctg caaggcactt gtatttatgg cagggattgt   1020

ttgaagcacc acactgtctt gccatatcat tggcagatca aaaggacaac tactcaaaag   1080

tggcagagtg tattcaatga ttctcaggag cacttggaaa gattttactg taacccagaa   1140

aatgatagaa tgagaatgaa gtatggagga caagaatttt gggcagattt gaatgccatg   1200

aacgtgtatg aaacaactga atttgaccaa ctacgaaggc tgtccacacc accctctagc   1260

aatgtcaact ctatttacca cacagtctgg aaattcttct gtagggacca ctttggatgg   1320

agagagtatc ccgagtctgt cattcgattg attgaagaag ccaactctcg gggtctgaaa   1380

gaggttcgat ttatgatgtg gaataaccac tacatcctcc acaattcatt cttcaggaga   1440

gagataaaaa ggagacccct cttccgctcc tgttttatac tgcttccata tttacagaca   1500

cttggtgggg ttcccacaca agctcctcca cctcttgaag caacttcatc atcacaaatt   1560

atctgcccag atggggtcac ttcagcaaac ttttaccctg aaacttgggt ttatatgcat   1620

ccatctcagg acttcatcca agtccctgtt tctgcagagg ataaaagtta tcggatcatt   1680

tacaatcttt ttcataagac tgtgcctgag tttaaataca gaattttgca gatattgaga   1740

gtccaaaacc agtttctttg ggagaaatat aaaaggaaaa aggaatatat gaacaggaaa   1800

atgtttggcc gtgacaggat aataaatgag agacatttat ttcatggaac atcccaggat   1860

gtggtagatg gaatctgcaa acacaacttt gaccctcgag tctgtggaaa gcatgctaca   1920

atgtttggac aaggcagtta ttttgcaaag aaggcaagct actctcataa cttttctaag   1980

aagtcctcca aaggagtcca cttcatgttt ctggccaaag tgctgacggg cagatacaca   2040

atgggcagtc atggcatgag aaggcccccg ccagtcaatc ctggcagtgt caccagtgac   2100

ctttatgact cttgtgtgga taatttcttt gagcctcaga tttttgtcat ttttaatgat   2160

gaccagagtt acccttattt tgttatccaa tatgaagaag tcagtaacac tgtttccatt   2220

tgaaaaatct tggtactgct aaattatttg atatgaactc aatccagcat ttgtagcagg   2280

ttttgaatgg gtgggactgg gtggggaaca gcattggaca ttaatagggc acttttcaga   2340

cccatttttt aaagtgctag aaaatgcttt ttttaaaaaa aaaatacaag ttttaaaatg   2400

accacttact ctttaattat ttactaattg ctagtgtact cagtgtggaa aagactacag   2460

attacacact cttttcattc acacttgtac atatagacag caatgttatt aggagcatta   2520

aattaaaaaa ctgaacagcc taatttaaat gtggcttggg cctggtagaa gtttgaccaa   2580

atggaatgga ggctgtgagc aatgtgagga ttctatttat ttatttacgt ttgataaaac   2640

ttactggaac tagtactacc atgcgtattc cctgtccaaa gcatcactgc tttggtatag   2700

tataagttca tgaaattctg gtgggtagaa agaaattttt atttctatca gcagtactaa   2760

aatgtatcag ccaaccagag aacatcagtg actttaactt ctgcagagtt tgccccagaa   2820

ttcagagttc tatttagagg aagttaaaac aacaacaaaa aacaaccatt tgaaaaattt   2880

ttgtcaccag caaaactttt cactaattag tgatatgaaa tgtgattttt gtgttgttaa   2940

acttcagctt tggaaaactc agtctctttc attatcatcc attccaattt gaaggagttg   3000

ggcagctaat ttggttaaag gcagtcttga gggttagaag tattacttcc ttttcgggtt   3060

ccagacctag cttgtgactg aaagttttag aaaaaggaag tacatctata gccgaattga   3120

taaggttatt actgtgtttt gcacaaagta tattagcaaa agtatttgct ggaattattg   3180

gtagatggca gtcccactcc tacacctgct ttgtcagata cagctgggtt ccctggctga   3240

ctctgtacct tacttacact acttacttaa tagaaacaca aacttggaaa ttgtgccagt   3300

ggtccagctg gagcacaacg tttggtgaat atgctgtttc ctcagttcag agaggtagca   3360

actaggtaaa ctccttataa aaagcaaata cctggattta caaaagtgaa agtagttgtt   3420

cacaaaagaa ttcgccatgg aattctttca gttaccaagc tctcctggta atgtttgtgg   3480

ttatatcatt tacacaaaac ttttcaggaa cttctgtgtt gtttaagcaa gatgtatctg   3540

tactgatgtc tcagtgaatc agtctgttta ttaagcactt atcagggctt ccacacactt   3600

atttattttg ccctagttaa tcctgttgtt tgctgccatt ggcatgaaat ggccaactgt   3660

ggctgttaca gttctttcat tcaattataa cttgtaaacc agtgactcct aatctttttc   3720

aagttaagac accttaccat tgcttatttg gttttatgag acttgttcct ttttttctcc   3780

ctaaggaaaa agaaagcttt atgacatatt tattttttta ataaaactaa gcaaaaacaa   3840

aaaaaaaaaa aaaaaaa                                                  3857


<210>  870
<211>  657
<212>  PRT
<213>  Homosapiens

<400>  870

Met Glu Met Glu Thr Thr Glu Pro Glu Pro Asp Cys Val Val Gln Pro 
1               5                   10                  15      


Pro Ser Pro Pro Asp Asp Phe Ser Cys Gln Met Arg Leu Ser Glu Lys 
            20                  25                  30          


Ile Thr Pro Leu Lys Thr Cys Phe Lys Lys Lys Asp Gln Lys Arg Leu 
        35                  40                  45              


Gly Thr Gly Thr Leu Arg Ser Leu Arg Pro Ile Leu Asn Thr Leu Leu 
    50                  55                  60                  


Glu Ser Gly Ser Leu Asp Gly Val Phe Arg Ser Arg Asn Gln Ser Thr 
65                  70                  75                  80  


Asp Glu Asn Ser Leu His Glu Pro Met Met Lys Lys Ala Met Glu Ile 
                85                  90                  95      


Asn Ser Ser Cys Pro Pro Ala Glu Asn Asn Met Ser Val Leu Ile Pro 
            100                 105                 110         


Asp Arg Thr Asn Val Gly Asp Gln Ile Pro Glu Ala His Pro Ser Thr 
        115                 120                 125             


Glu Ala Pro Glu Arg Val Val Pro Ile Gln Asp His Ser Phe Pro Ser 
    130                 135                 140                 


Glu Thr Leu Ser Gly Thr Val Ala Asp Ser Thr Pro Ala His Phe Gln 
145                 150                 155                 160 


Thr Asp Leu Leu His Pro Val Ser Ser Asp Val Pro Thr Ser Pro Asp 
                165                 170                 175     


Cys Leu Asp Lys Val Ile Asp Tyr Val Pro Gly Ile Phe Gln Glu Asn 
            180                 185                 190         


Ser Phe Thr Ile Gln Tyr Ile Leu Asp Thr Ser Asp Lys Leu Ser Thr 
        195                 200                 205             


Glu Leu Phe Gln Asp Lys Ser Glu Glu Ala Ser Leu Asp Leu Val Phe 
    210                 215                 220                 


Glu Leu Val Asn Gln Leu Gln Tyr His Thr His Gln Glu Asn Gly Ile 
225                 230                 235                 240 


Glu Ile Cys Met Asp Phe Leu Gln Gly Thr Cys Ile Tyr Gly Arg Asp 
                245                 250                 255     


Cys Leu Lys His His Thr Val Leu Pro Tyr His Trp Gln Ile Lys Arg 
            260                 265                 270         


Thr Thr Thr Gln Lys Trp Gln Ser Val Phe Asn Asp Ser Gln Glu His 
        275                 280                 285             


Leu Glu Arg Phe Tyr Cys Asn Pro Glu Asn Asp Arg Met Arg Met Lys 
    290                 295                 300                 


Tyr Gly Gly Gln Glu Phe Trp Ala Asp Leu Asn Ala Met Asn Val Tyr 
305                 310                 315                 320 


Glu Thr Thr Glu Phe Asp Gln Leu Arg Arg Leu Ser Thr Pro Pro Ser 
                325                 330                 335     


Ser Asn Val Asn Ser Ile Tyr His Thr Val Trp Lys Phe Phe Cys Arg 
            340                 345                 350         


Asp His Phe Gly Trp Arg Glu Tyr Pro Glu Ser Val Ile Arg Leu Ile 
        355                 360                 365             


Glu Glu Ala Asn Ser Arg Gly Leu Lys Glu Val Arg Phe Met Met Trp 
    370                 375                 380                 


Asn Asn His Tyr Ile Leu His Asn Ser Phe Phe Arg Arg Glu Ile Lys 
385                 390                 395                 400 


Arg Arg Pro Leu Phe Arg Ser Cys Phe Ile Leu Leu Pro Tyr Leu Gln 
                405                 410                 415     


Thr Leu Gly Gly Val Pro Thr Gln Ala Pro Pro Pro Leu Glu Ala Thr 
            420                 425                 430         


Ser Ser Ser Gln Ile Ile Cys Pro Asp Gly Val Thr Ser Ala Asn Phe 
        435                 440                 445             


Tyr Pro Glu Thr Trp Val Tyr Met His Pro Ser Gln Asp Phe Ile Gln 
    450                 455                 460                 


Val Pro Val Ser Ala Glu Asp Lys Ser Tyr Arg Ile Ile Tyr Asn Leu 
465                 470                 475                 480 


Phe His Lys Thr Val Pro Glu Phe Lys Tyr Arg Ile Leu Gln Ile Leu 
                485                 490                 495     


Arg Val Gln Asn Gln Phe Leu Trp Glu Lys Tyr Lys Arg Lys Lys Glu 
            500                 505                 510         


Tyr Met Asn Arg Lys Met Phe Gly Arg Asp Arg Ile Ile Asn Glu Arg 
        515                 520                 525             


His Leu Phe His Gly Thr Ser Gln Asp Val Val Asp Gly Ile Cys Lys 
    530                 535                 540                 


His Asn Phe Asp Pro Arg Val Cys Gly Lys His Ala Thr Met Phe Gly 
545                 550                 555                 560 


Gln Gly Ser Tyr Phe Ala Lys Lys Ala Ser Tyr Ser His Asn Phe Ser 
                565                 570                 575     


Lys Lys Ser Ser Lys Gly Val His Phe Met Phe Leu Ala Lys Val Leu 
            580                 585                 590         


Thr Gly Arg Tyr Thr Met Gly Ser His Gly Met Arg Arg Pro Pro Pro 
        595                 600                 605             


Val Asn Pro Gly Ser Val Thr Ser Asp Leu Tyr Asp Ser Cys Val Asp 
    610                 615                 620                 


Asn Phe Phe Glu Pro Gln Ile Phe Val Ile Phe Asn Asp Asp Gln Ser 
625                 630                 635                 640 


Tyr Pro Tyr Phe Val Ile Gln Tyr Glu Glu Val Ser Asn Thr Val Ser 
                645                 650                 655     


Ile 
    


<210>  871
<211>  2881
<212>  DNA
<213>  Homosapiens

<400>  871
agccgactgg cggcgcggtc gcccgggaga ccgggaaagc cgtttcacac ccgtcctagt     60

cgaagtcgag atttcctttg gcttcaaagc tctctcacca tattttggga agttatggat    120

catcacattc ccatgcatgc gttgcctgaa gaaatccaaa agatgttgcc tgaagaaaaa    180

gtttgtaagt actgtggagt cagctatcta attcttcatg aatttaaggc tatggaagaa    240

aaagtgaaag caatggaaaa agagatgaaa ttttatcaag gaagtataga tcgtgaaaag    300

agacttcaag aaaagctgca ttctcttagc caagaacttg aacagtacaa aattgacaac    360

aaatccaaaa cagaaagaat ttacgatgta ggcatgcagt taaaaagtca acaaaatgaa    420

tttcagaaag taaagaaaca actgagtcat ttgcaagatg agctaaaaat taaatataga    480

caatcataca tcttcagtca aagattgtca gagtacaaat atttctggaa taagactctt    540

tcattactta cttttactaa aagggaacta accagtatta aaaatgaagt atatgataat    600

taccaaaact ggacttcatt gaaaggagca gtttttctac aaattaaatc tataagtgaa    660

acagccttga cagaaataga catactgaat aaaagttcga cagtatccca gagaaataaa    720

gtatgccttg aaaaggaaat gaaaaatctg aaattgttgt cagatgcagc catattgaga    780

tctcagcaga ttcggacatc tagacaacag gaagtaaact tgcaaaccag atgctatgat    840

ttgcaaaaag aagtactaga tttacaatgt ctagtagagg cacttggatt aaaacttcag    900

aaggcggtga cagagatgga caactataaa gaaatgctta tgtaagatgg agaatattaa    960

acaacttata acagtgctct gtagatgtgt tacaaaatgg caagaattag gaagaaatga   1020

caagaattat aaagaccctg cctgggcaac acggagaaac tttgtctcca caaaaaaata   1080

caaaaattat ccatgcgtgt tggcacactc ctgtagtccc agctactcgg gaggctgaac   1140

tgggaagatc acctaagcct agaaagttga agctacagtg aaccatgatt atgccactac   1200

actccagcct gggcgacaga gtgagaccct gtctcaaaat gaataaataa gaataaatct   1260

aatgaagctg atgactgtca aagagaactt aaaaaactga agtttgaatc cattatttct   1320

gagtcacagc atactatgct gcttaaggaa aaagaagact ctttaatgac ttgtcaacag   1380

atatataaag cattacagga agagctgact gtgaaagaaa agcaagaaga agacataaag   1440

agaagaatta accttgcaga aaatgaactg gagataacca aaactcttct gaatcagaca   1500

agggaagagg ttttaacact gaaaaatgaa agggaattga tgctgatttc acatcagaaa   1560

agcatcgagc agctgcaaga aacccttaga cagaagctgc tgagtgatga taactggaag   1620

gagaagattg aagcagaact tgccaaggaa agggcccaac acttggttga atttgaagag   1680

caagctcttc tctttaagga agaaacaaaa ttgcaacttg atattgaaaa agaaaaacac   1740

caagatgtaa tccaaaagta taagaaagaa caagaggaac tacaaatgaa gatatctgac   1800

ttaatcacag gcgctacaag agatctaagg caggaagtga ccactcttaa agaaaaactt   1860

cacaaatccc atactcggta cactgaagaa tctaattcaa aggaaaaaga aattgaaaat   1920

cttaaaaatt tggttgcaga atttgaatct cgcttgaaga aggaaattga cagtaatgat   1980

tcagtttcag aaaacttgag gaaggaaatg gaacagaagt cggatgaact gaaaagagta   2040

atgctggctc aaacacaact gatagagcaa tttaaccagt cccaggaaga gaatactttt   2100

cttcaggaga cagtgcgtag agaatgtgaa gaacgctttg aactgacaga ggctttgagt   2160

caagccagag aacagctcct ggagctcagt aagcttcgtg gaagtttacc attctcaccg   2220

tgttccctca gcaagggcag cctaacctcc cctgctgcag cagtcagtaa tcatggagag   2280

agaagccttg caagactgaa ctctgaaaaa ggaatccaaa ttcccaacct gcgcggggtg   2340

tcaaaaccca ccactttccc aacctcagat aagccgaaga gggttagatc aggcgtgccc   2400

attctccccc agccacatcc tcccaggggt ggagcatctt cagcaaatga gactagacag   2460

agactggctg ccattcttag gagaaggcgg agtcagcaat gatccaaaat gaggagcagg   2520

aagctcccta cagcgtgcac gctctttcag agagtgccag gaattcactg taactgagaa   2580

tgacaatgat aaaattattt tcacagatca ggaaggcata cctatagatg tatttaacaa   2640

aagactgtaa aaagctggaa aattgtgaag ccttattttt caagagggtt ttgatagagt   2700

aacagatcat taagttgttg gtattccaga ggtccgattt ctatgtttat gttggaatgt   2760

gctctatgaa tatagccttt tagagatcac aggtaaaatt tttcacccat aacatctttt   2820

caatttcttg cgccactaca agcagatata tttccacaaa aaaatagatt gtttgagatt   2880

t                                                                   2881


<210>  872
<211>  388
<212>  PRT
<213>  Homosapiens

<400>  872

Met Leu Leu Lys Glu Lys Glu Asp Ser Leu Met Thr Cys Gln Gln Ile 
1               5                   10                  15      


Tyr Lys Ala Leu Gln Glu Glu Leu Thr Val Lys Glu Lys Gln Glu Glu 
            20                  25                  30          


Asp Ile Lys Arg Arg Ile Asn Leu Ala Glu Asn Glu Leu Glu Ile Thr 
        35                  40                  45              


Lys Thr Leu Leu Asn Gln Thr Arg Glu Glu Val Leu Thr Leu Lys Asn 
    50                  55                  60                  


Glu Arg Glu Leu Met Leu Ile Ser His Gln Lys Ser Ile Glu Gln Leu 
65                  70                  75                  80  


Gln Glu Thr Leu Arg Gln Lys Leu Leu Ser Asp Asp Asn Trp Lys Glu 
                85                  90                  95      


Lys Ile Glu Ala Glu Leu Ala Lys Glu Arg Ala Gln His Leu Val Glu 
            100                 105                 110         


Phe Glu Glu Gln Ala Leu Leu Phe Lys Glu Glu Thr Lys Leu Gln Leu 
        115                 120                 125             


Asp Ile Glu Lys Glu Lys His Gln Asp Val Ile Gln Lys Tyr Lys Lys 
    130                 135                 140                 


Glu Gln Glu Glu Leu Gln Met Lys Ile Ser Asp Leu Ile Thr Gly Ala 
145                 150                 155                 160 


Thr Arg Asp Leu Arg Gln Glu Val Thr Thr Leu Lys Glu Lys Leu His 
                165                 170                 175     


Lys Ser His Thr Arg Tyr Thr Glu Glu Ser Asn Ser Lys Glu Lys Glu 
            180                 185                 190         


Ile Glu Asn Leu Lys Asn Leu Val Ala Glu Phe Glu Ser Arg Leu Lys 
        195                 200                 205             


Lys Glu Ile Asp Ser Asn Asp Ser Val Ser Glu Asn Leu Arg Lys Glu 
    210                 215                 220                 


Met Glu Gln Lys Ser Asp Glu Leu Lys Arg Val Met Leu Ala Gln Thr 
225                 230                 235                 240 


Gln Leu Ile Glu Gln Phe Asn Gln Ser Gln Glu Glu Asn Thr Phe Leu 
                245                 250                 255     


Gln Glu Thr Val Arg Arg Glu Cys Glu Glu Arg Phe Glu Leu Thr Glu 
            260                 265                 270         


Ala Leu Ser Gln Ala Arg Glu Gln Leu Leu Glu Leu Ser Lys Leu Arg 
        275                 280                 285             


Gly Ser Leu Pro Phe Ser Pro Cys Ser Leu Ser Lys Gly Ser Leu Thr 
    290                 295                 300                 


Ser Pro Ala Ala Ala Val Ser Asn His Gly Glu Arg Ser Leu Ala Arg 
305                 310                 315                 320 


Leu Asn Ser Glu Lys Gly Ile Gln Ile Pro Asn Leu Arg Gly Val Ser 
                325                 330                 335     


Lys Pro Thr Thr Phe Pro Thr Ser Asp Lys Pro Lys Arg Val Arg Ser 
            340                 345                 350         


Gly Val Pro Ile Leu Pro Gln Pro His Pro Pro Arg Gly Gly Ala Ser 
        355                 360                 365             


Ser Ala Asn Glu Thr Arg Gln Arg Leu Ala Ala Ile Leu Arg Arg Arg 
    370                 375                 380                 


Arg Ser Gln Gln 
385             


<210>  873
<211>  2625
<212>  DNA
<213>  Homosapiens

<400>  873
atagggtcca cagccttgtg ttcttcaaat actgtaaagc agccctctcc agattccttg     60

agggtcactt tatattacac attcgtccac acaggacaac aaagtcacca cttccacccg    120

ccaaagcgcg ctcaggtcgg ccgccacttc ccttggtaca cgcggaacgc aagccgcgcc    180

gaggctaaag gaagaggccg gaatgcaggg cgaaggggcg cagagatgct agccaatgct    240

gccacctcta ttttggatat aagggatctt gtaaagctcc gttattcgtg tggctatcac    300

aaacaaggtg gtttcgaccg gccttggcta gagaaggcct cctcagcctc tgaggatccc    360

aaggtctgtc gcagcaccca acactcccct cgcaggccca gatgccgagg gcggaggcgc    420

ggcctggagg gactagttgg cgcgcggctg cccggcgtgg tgacgtcagg gcggaagcgc    480

acgcggcgtg aagcggccca gaacccggcg gtcacgggaa tatccgtcgc gccgagaacg    540

ctggttagtc ttgtttcggg ttccggctgc gttgggcttg cgtgcggctc gctaagacta    600

tggcgtccgg gcctcattcg acagctactg ctgccgcagc cgcctcatcg gccgccccaa    660

gcgcgggcgg ctccagctcc gggacgacga ccacgacgac gaccacgacg ggagggatcc    720

tgatcggcga tcgcctgtac tcggaagttt cacttaccat cgaccactct ctgattccgg    780

aggagaggct ctcgcccacc ccatccatgc aggatgggct cgacctgccc agtgagacgg    840

acttacgcat cctgggctgc gagctcatcc aggccgccgg cattctcctc cggctgccgc    900

aggtggcgat ggcaacgggg caggtgttgt ttcatcgttt tttctactcc aaatctttcg    960

tcaaacacag tttcgagatt gttgctatgg cttgtattaa tcttgcatca aaaatcgaag   1020

aagcacctag aagaataaga gatgtgatta atgtattcca ccacctccgc cagttaagag   1080

gaaaaaggac tccaagcccc ctgatccttg atcagaacta cattaacacc aaaaatcaag   1140

ttatcaaagc agagaggagg gtgctaaagg agttgggatt ttgtgttcat gtcaagcatc   1200

ctcataagat cattgttatg tatttacaag tcttagaatg tgaacgtaat caaaccctgg   1260

ttcaaactgc ctggaattac atgaatgaca gtcttcgaac caatgtgttt gttcgatttc   1320

aaccagagac tatagcatgt gcttgcatct accttgcagc tagagcactt cagattccgt   1380

tgccaactcg tccccattgg tttcttcttt ttggtactac agaagaggaa atccaggaaa   1440

tctgcataga aacacttagg ctttatacca gaaaaaagcc aaactatgaa ttactggaaa   1500

aagaagtaga aaaaagaaaa gtagccttac aagaagccaa attaaaagca aagggattga   1560

atccggatgg aactccagcc ctttcaaccc tgggtggatt ttctccagcc tccaagccat   1620

catcaccaag agaagtaaaa gctgaagaga aatcaccaat ctccattaat gtgaagacag   1680

tcaaaaaaga acctgaggat agacaacagg cttccaaaag cccttacaat ggtgtaagaa   1740

aagacagcaa gagaagtaga aatagcagaa gtgcaagtcg atcgaggtca agaacacgat   1800

cacgttctag atcacatact ccaagaagac actataataa taggcggagt cgatctggaa   1860

catacagctc gagatcaaga agcaggtccc gcagtcacag tgaaagccct cgaagacatc   1920

ataatcatgg ttctcctcac cttaaggcca agcataccag agatgattta aaaagttcaa   1980

acagacatgg tcataaaagg aaaaaatctc gttctcgatc tcagagcaag tctcgggatc   2040

actcagatgc agccaagaaa cacaggcatg aaaggggaca tcatagggac aggcgtgaac   2100

gatctcgctc ctttgagagg tcccataaaa gcaagcacca tggtggcagt cgctcaggac   2160

atggcaggca caggcgctga ctttctcttc ctttgagcct gcatcagttc ttggttttgc   2220

ctatctacag tgtgatgtat ggactcaatc aaaaacatta aacgcaaact gattaggatt   2280

tgatttcttg aaaccctcta ggtctctaga acactgagga cagtttcttt tgaaaagaac   2340

tatgttaatt tttttgcaca ttaaaatgcc ctagcagtat ctaattaaaa accatggtca   2400

ggttcaattg tactttatta tagttgtgta ttgtttattg ctataagaac tggagcgtga   2460

attctgtaaa aatgtatctt atttttatac agataaaatt gcagacactg ttctatttaa   2520

gtggttattt gtttaaatga tggtgaatac tttcttaaca ctggtttgtc tgcatgtgta   2580

aagattttta caaggaaata aaatacaaat cttgtttttt ctaaa                   2625


<210>  874
<211>  526
<212>  PRT
<213>  Homosapiens

<400>  874

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
            20                  25                  30          


Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
        35                  40                  45              


Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
    50                  55                  60                  


Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
65                  70                  75                  80  


Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                85                  90                  95      


Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
            100                 105                 110         


Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
        115                 120                 125             


Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
    130                 135                 140                 


Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
145                 150                 155                 160 


Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile Asn 
                165                 170                 175     


Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu 
            180                 185                 190         


Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met Tyr 
        195                 200                 205             


Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr Ala 
    210                 215                 220                 


Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg Phe 
225                 230                 235                 240 


Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Ala 
                245                 250                 255     


Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe Gly 
            260                 265                 270         


Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg Leu 
        275                 280                 285             


Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val Glu 
    290                 295                 300                 


Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly Leu 
305                 310                 315                 320 


Asn Pro Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser Pro 
                325                 330                 335     


Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys Ser 
            340                 345                 350         


Pro Ile Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp Arg 
        355                 360                 365             


Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser Lys 
    370                 375                 380                 


Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr Arg 
385                 390                 395                 400 


Ser Arg Ser Arg Ser His Thr Pro Arg Arg His Tyr Asn Asn Arg Arg 
                405                 410                 415     


Ser Arg Ser Gly Thr Tyr Ser Ser Arg Ser Arg Ser Arg Ser Arg Ser 
            420                 425                 430         


His Ser Glu Ser Pro Arg Arg His His Asn His Gly Ser Pro His Leu 
        435                 440                 445             


Lys Ala Lys His Thr Arg Asp Asp Leu Lys Ser Ser Asn Arg His Gly 
    450                 455                 460                 


His Lys Arg Lys Lys Ser Arg Ser Arg Ser Gln Ser Lys Ser Arg Asp 
465                 470                 475                 480 


His Ser Asp Ala Ala Lys Lys His Arg His Glu Arg Gly His His Arg 
                485                 490                 495     


Asp Arg Arg Glu Arg Ser Arg Ser Phe Glu Arg Ser His Lys Ser Lys 
            500                 505                 510         


His His Gly Gly Ser Arg Ser Gly His Gly Arg His Arg Arg 
        515                 520                 525     


<210>  875
<211>  3044
<212>  DNA
<213>  Homosapiens

<400>  875
attcttccac ccggcaccgg ctccgcaatg aacaacttca ggttcactga gctgagcgga     60

ttccactcgc tgtgccctcg gagcctgcct gaatctcccg cccagtctca aaccatgcag    120

ctgagtaact gcaagggcgc ctttgaggag tagcacgcag agagtgtcaa tgaagacctc    180

aaagtctgga gaaaaatgac ctttcatgga ataagaagta tacctccttc tacatgtttt    240

tgtcttactg acctctgata actggaacac atgactctgg gtctgtagaa agtcaactga    300

tcaaactcat cctcaccatg catcaactgt tcagactggt tttgggacaa aaagatcttt    360

cacgagctgg ggacctcttc tccttagatg actctgagat tgaagacagc cttacagaag    420

ctttggagca aattaagata attagctcat cttcagatta ccaaaccaat aacaatgacc    480

aggcagtagt tgaaatctgt atcacaagaa tcacaacagc catcagagag accgagtcca    540

ttgaaaagca tgcaaaggcc cttgtggggc tctgggactc ctgcttggaa cataacctga    600

gaccctttgg gaaagacgaa gacactcctc atgcaaaaat cgcatctgat atcatgagtt    660

gcattttaca gaattacaac cgacccccag tgatggcatt agccatcccc attgcagtga    720

aattcctcca cagaggcaac aaggaactgt gcaggaatat gtctaactac ctgtctctgg    780

ctgcaattac caaggcagat ctcctggctg atcacacgga agttatagta aagagcatac    840

tccaaggtaa caccatgttg ttgagagtgt tacctgctgt gtatgaaaag cagcctcagc    900

caattaatag acacctgaca gaactcctgg ccttgatgtc tcagctggaa cagccagaac    960

agtaccatct actacggctt ttgcatgtag cagcaaagaa aaaacaactc gaggtagttc   1020

agaagtgtat tcctttccta attgggcatt tgaaggattc aacccataat gacatcatcc   1080

taaacatcct catggagata gcagtctatg agccagtggc tttgaacagt tttcttccaa   1140

tgctgaaaga gattggtgag agattcccct acctcactgg acagatggca aggatttatg   1200

gagctgttgg gcatgtggat gaagagagag ccaggagctg cctgacatac ctggtgagcc   1260

aactggccaa catggagcat tcgtttcacc atattctcct gctggagatt aaaagcatca   1320

ccgacacctt ctcctcaatc ttgggccctc agagcagaga catcttccgc atgagcaaca   1380

gcttcaccgc cattgctaaa ctccttaccc gacaactgga aaataccaag gctggaagtg   1440

gcaggagaaa aatcagcact gaaattgaat tccctgagaa actggaagaa accaagctca   1500

tagtaactga aaatgaagac catgaaaaac tccaagttaa aatccaggct tttgaagaca   1560

agataaatgc agggagcaat acccctggct ctatcagaag atatagtctg ggccaagttt   1620

ctaaagaaga aagaaaaaac attagattta acaggtcaaa aagtttggct ttccacacta   1680

tgctcacaaa gggtgtgggt tcagatgacg gcgaagatga aaacagggga gacataccag   1740

ccagcatctc tctttcagaa atagacccac ttggccaagg aaatgacaag ctgccgttta   1800

agacagacac tgagagatca cagctggggg agtcttcagt ttcataccca aatattatac   1860

atatagactc agagaatttg tcagaaactg ttaaagaaaa ctcccaggaa gaaactccag   1920

agacaactgc aagtcctata gaataccaag ataagctcta cttgcactta aaaaaaaacc   1980

tcagcaaagt gaaagcatat gccatggaaa ttggaaagaa gattccagtc cctgatcagt   2040

gtaccattga agacactgtg agaagttgtg tagcaaagtt gttcttcacc tgctccctga   2100

agggtcatta ctgcctatac agtaagtcca gttttattct catcagccaa gaacctcagc   2160

catggatcca gatcatgttt ctatttcagc agagcctgtt tcctgaaccc ctgtccattc   2220

agagtcattc tgtgcaattc ctcagagctc tgtgggagaa gacccaggca gggggtgctc   2280

acagctttga aactgccatg atggagtcca cgtttccaca gcagaaggat ctggaccagg   2340

tacagctcca tctggaagaa gtgaggttct ttgacgtgtt tggcttcagt gaaacagcag   2400

gagcatggca atgcttcatg tgcaacaatc ctgagaaagc aactgttgta aatcaagatg   2460

gccagcctct catagaagga aaacttaaag agaagcaagt cagatggaag ttcatcaaaa   2520

ggtggaaaac acgctatttt acactggctg gaaatcaact tctgtttcaa aaaggaaagt   2580

ctaaagatga ccctgacgac tgcccaatag aactcagcaa agtacagagt gtgaaggctg   2640

tggccaagaa acgcagggac cgctctctcc cccgggcttt cgaaatcttc acagacaata   2700

aaacctatgt ctttaaggcc aaggatgaga agaatgcagc agaatggctc cagtgcatca   2760

acgtggcagt tgcccaagcc aaagaaaggg aaagtagaga agtaaccaca tatctgtagg   2820

gatttataag tcagccatga caattataca ccacaggcat tgtattatca ttgccaatgt   2880

caagaaaaag agctaaattt accaagccat gttgtttttt actaaatacc aatggaattg   2940

ttgtccttta agaagaaggg cctaaaatgg caggattctt agtaaatgtc atactctaac   3000

agctttagta ttgacttcag aatatatctg atgcccacaa aaat                    3044


<210>  876
<211>  833
<212>  PRT
<213>  Homosapiens

<400>  876

Met His Gln Leu Phe Arg Leu Val Leu Gly Gln Lys Asp Leu Ser Arg 
1               5                   10                  15      


Ala Gly Asp Leu Phe Ser Leu Asp Asp Ser Glu Ile Glu Asp Ser Leu 
            20                  25                  30          


Thr Glu Ala Leu Glu Gln Ile Lys Ile Ile Ser Ser Ser Ser Asp Tyr 
        35                  40                  45              


Gln Thr Asn Asn Asn Asp Gln Ala Val Val Glu Ile Cys Ile Thr Arg 
    50                  55                  60                  


Ile Thr Thr Ala Ile Arg Glu Thr Glu Ser Ile Glu Lys His Ala Lys 
65                  70                  75                  80  


Ala Leu Val Gly Leu Trp Asp Ser Cys Leu Glu His Asn Leu Arg Pro 
                85                  90                  95      


Phe Gly Lys Asp Glu Asp Thr Pro His Ala Lys Ile Ala Ser Asp Ile 
            100                 105                 110         


Met Ser Cys Ile Leu Gln Asn Tyr Asn Arg Pro Pro Val Met Ala Leu 
        115                 120                 125             


Ala Ile Pro Ile Ala Val Lys Phe Leu His Arg Gly Asn Lys Glu Leu 
    130                 135                 140                 


Cys Arg Asn Met Ser Asn Tyr Leu Ser Leu Ala Ala Ile Thr Lys Ala 
145                 150                 155                 160 


Asp Leu Leu Ala Asp His Thr Glu Val Ile Val Lys Ser Ile Leu Gln 
                165                 170                 175     


Gly Asn Thr Met Leu Leu Arg Val Leu Pro Ala Val Tyr Glu Lys Gln 
            180                 185                 190         


Pro Gln Pro Ile Asn Arg His Leu Thr Glu Leu Leu Ala Leu Met Ser 
        195                 200                 205             


Gln Leu Glu Gln Pro Glu Gln Tyr His Leu Leu Arg Leu Leu His Val 
    210                 215                 220                 


Ala Ala Lys Lys Lys Gln Leu Glu Val Val Gln Lys Cys Ile Pro Phe 
225                 230                 235                 240 


Leu Ile Gly His Leu Lys Asp Ser Thr His Asn Asp Ile Ile Leu Asn 
                245                 250                 255     


Ile Leu Met Glu Ile Ala Val Tyr Glu Pro Val Ala Leu Asn Ser Phe 
            260                 265                 270         


Leu Pro Met Leu Lys Glu Ile Gly Glu Arg Phe Pro Tyr Leu Thr Gly 
        275                 280                 285             


Gln Met Ala Arg Ile Tyr Gly Ala Val Gly His Val Asp Glu Glu Arg 
    290                 295                 300                 


Ala Arg Ser Cys Leu Thr Tyr Leu Val Ser Gln Leu Ala Asn Met Glu 
305                 310                 315                 320 


His Ser Phe His His Ile Leu Leu Leu Glu Ile Lys Ser Ile Thr Asp 
                325                 330                 335     


Thr Phe Ser Ser Ile Leu Gly Pro Gln Ser Arg Asp Ile Phe Arg Met 
            340                 345                 350         


Ser Asn Ser Phe Thr Ala Ile Ala Lys Leu Leu Thr Arg Gln Leu Glu 
        355                 360                 365             


Asn Thr Lys Ala Gly Ser Gly Arg Arg Lys Ile Ser Thr Glu Ile Glu 
    370                 375                 380                 


Phe Pro Glu Lys Leu Glu Glu Thr Lys Leu Ile Val Thr Glu Asn Glu 
385                 390                 395                 400 


Asp His Glu Lys Leu Gln Val Lys Ile Gln Ala Phe Glu Asp Lys Ile 
                405                 410                 415     


Asn Ala Gly Ser Asn Thr Pro Gly Ser Ile Arg Arg Tyr Ser Leu Gly 
            420                 425                 430         


Gln Val Ser Lys Glu Glu Arg Lys Asn Ile Arg Phe Asn Arg Ser Lys 
        435                 440                 445             


Ser Leu Ala Phe His Thr Met Leu Thr Lys Gly Val Gly Ser Asp Asp 
    450                 455                 460                 


Gly Glu Asp Glu Asn Arg Gly Asp Ile Pro Ala Ser Ile Ser Leu Ser 
465                 470                 475                 480 


Glu Ile Asp Pro Leu Gly Gln Gly Asn Asp Lys Leu Pro Phe Lys Thr 
                485                 490                 495     


Asp Thr Glu Arg Ser Gln Leu Gly Glu Ser Ser Val Ser Tyr Pro Asn 
            500                 505                 510         


Ile Ile His Ile Asp Ser Glu Asn Leu Ser Glu Thr Val Lys Glu Asn 
        515                 520                 525             


Ser Gln Glu Glu Thr Pro Glu Thr Thr Ala Ser Pro Ile Glu Tyr Gln 
    530                 535                 540                 


Asp Lys Leu Tyr Leu His Leu Lys Lys Asn Leu Ser Lys Val Lys Ala 
545                 550                 555                 560 


Tyr Ala Met Glu Ile Gly Lys Lys Ile Pro Val Pro Asp Gln Cys Thr 
                565                 570                 575     


Ile Glu Asp Thr Val Arg Ser Cys Val Ala Lys Leu Phe Phe Thr Cys 
            580                 585                 590         


Ser Leu Lys Gly His Tyr Cys Leu Tyr Ser Lys Ser Ser Phe Ile Leu 
        595                 600                 605             


Ile Ser Gln Glu Pro Gln Pro Trp Ile Gln Ile Met Phe Leu Phe Gln 
    610                 615                 620                 


Gln Ser Leu Phe Pro Glu Pro Leu Ser Ile Gln Ser His Ser Val Gln 
625                 630                 635                 640 


Phe Leu Arg Ala Leu Trp Glu Lys Thr Gln Ala Gly Gly Ala His Ser 
                645                 650                 655     


Phe Glu Thr Ala Met Met Glu Ser Thr Phe Pro Gln Gln Lys Asp Leu 
            660                 665                 670         


Asp Gln Val Gln Leu His Leu Glu Glu Val Arg Phe Phe Asp Val Phe 
        675                 680                 685             


Gly Phe Ser Glu Thr Ala Gly Ala Trp Gln Cys Phe Met Cys Asn Asn 
    690                 695                 700                 


Pro Glu Lys Ala Thr Val Val Asn Gln Asp Gly Gln Pro Leu Ile Glu 
705                 710                 715                 720 


Gly Lys Leu Lys Glu Lys Gln Val Arg Trp Lys Phe Ile Lys Arg Trp 
                725                 730                 735     


Lys Thr Arg Tyr Phe Thr Leu Ala Gly Asn Gln Leu Leu Phe Gln Lys 
            740                 745                 750         


Gly Lys Ser Lys Asp Asp Pro Asp Asp Cys Pro Ile Glu Leu Ser Lys 
        755                 760                 765             


Val Gln Ser Val Lys Ala Val Ala Lys Lys Arg Arg Asp Arg Ser Leu 
    770                 775                 780                 


Pro Arg Ala Phe Glu Ile Phe Thr Asp Asn Lys Thr Tyr Val Phe Lys 
785                 790                 795                 800 


Ala Lys Asp Glu Lys Asn Ala Ala Glu Trp Leu Gln Cys Ile Asn Val 
                805                 810                 815     


Ala Val Ala Gln Ala Lys Glu Arg Glu Ser Arg Glu Val Thr Thr Tyr 
            820                 825                 830         


Leu 
    


<210>  877
<211>  2112
<212>  DNA
<213>  Homosapiens

<400>  877
cggctttcaa agccaatttg aataaacaac tcttccctct caaatgggca agagtaactc     60

ttcagcacca tggagaggtc cgggcagcgt gttacaacgt gggactgtga ccagggcaag    120

cactctgaca gtgattaccg agaggatggg atggatctag gcagtgacgc cggcagcagc    180

agcagcagca gccgcgccag ttcacagtcc aactccacca aagtgacccc ttgctccgag    240

tgcaaatctt catcgtcgcc ggggggcagc ctggacttgg tgtctgccct ggaggactat    300

gaggagccct tcccggtcta ccagaagaag gtgattgatg agtgggcgcc ggaggaggac    360

ggggaggagg aggaagagga ggacgagcgc gaccagcgag ggtaccggga tgaccgctct    420

ccggcccggg aaccggggga cgtaagcgcc aggacccgca gcggcggcgg cgggggcagg    480

agcgccacca ccgccatgcc gcccccggtg cccaacggca acctccacca gcacgacccc    540

caggacctca ggcacaatgg caacgtggtg gtggctggcc ggccgagctg ttcccggggc    600

ccccgccggg cgatccaaaa gccccagccg gctgggggcc ggcgcagtgg ccgcggcccg    660

gcggctgggg ggctctgcct tcagccccca gacggcggga cgtgcgtccc cgaagagccc    720

ccggtgccac ctatggattg ggaggcgctg gagaagcatc tggccgggct gcagttccgg    780

gagcaggagg tacggaacca gggccaggcg aggaccaact ccacctccgc acagaaaaat    840

gagagagagt ctatcagaca gaagttggca cttggaagct tctttgatga tggcccagga    900

atttatacca gctgtagcaa aagtgggaag ccaagccttt cctcccgact gcagagtggg    960

atgaacttgc agatatgctt tgtcaacgac agtggcagtg ataaggacag tgatgctgat   1020

gacagtaaga ctgaaaccag cttggacacc cccttgtctc ccatgagcaa acagagttct   1080

tcctattctg atagagacac tactgaagag gagtctgaat ccttggatga catggacttc   1140

cttacaaggc aaaagaaatt gcaagctgaa gccaaaatgg cccttgccat ggccaaacca   1200

atggccaaaa tgcaagtaga agtggagaaa cagaacagga aaaagtctcc cgtcgctgat   1260

cttctgccac acatgcctca tataagtgaa tgcttgatga aaagaagttt aaaacccacc   1320

gacctgagag acatgactat tgggcagcta caagtgatag tcaatgatct ccattcccag   1380

atagaaagct tgaatgaaga gttggtccag ctgcttctca tccgagatga gctgcacaca   1440

gagcaggatg ccatgctggt ggacattgaa gacttgacca gacatgctga aagtcagcag   1500

aagcacatgg cagagaaaat gcctgcaaag tgaaaagaag ccattcaacc agagaacaag   1560

ctagaattta ttttgcttct gtggttgtaa aaatgctgtt gctaaaggtg gcgcagaaac   1620

aaatatcagt gttagtcatt gataatgtct gaagcttaat gtccagtgat tggcctttgc   1680

ttcttaattt attttaattt tttacttgtg ccacttaata tcaggcattt taataaaata   1740

ttgttacaaa aaatgtacag tactgacacc accacaaatc atggttaata aaagagagta   1800

gttttaactt tatttttatt tgtttagaga ttttaagttg gaacagtatt ttcccattga   1860

ctacttttca ttcttcactg tagttttaaa gaagaactgt aaatgacggt gctatacaag   1920

tcaaaaaata catgcctgcc tcgtagtgaa gttgtagctc tccgtaatat gtatatttta   1980

ctcagttttc aacattttgt gaatgttgac tacctgaagt tcctttttag atgtgctatt   2040

aacattctgt tggattcaga gggttccttg aaagttttat gtataaatat gtaaaataaa   2100

aattaaaacc cg                                                       2112


<210>  878
<211>  487
<212>  PRT
<213>  Homosapiens

<400>  878

Met Glu Arg Ser Gly Gln Arg Val Thr Thr Trp Asp Cys Asp Gln Gly 
1               5                   10                  15      


Lys His Ser Asp Ser Asp Tyr Arg Glu Asp Gly Met Asp Leu Gly Ser 
            20                  25                  30          


Asp Ala Gly Ser Ser Ser Ser Ser Ser Arg Ala Ser Ser Gln Ser Asn 
        35                  40                  45              


Ser Thr Lys Val Thr Pro Cys Ser Glu Cys Lys Ser Ser Ser Ser Pro 
    50                  55                  60                  


Gly Gly Ser Leu Asp Leu Val Ser Ala Leu Glu Asp Tyr Glu Glu Pro 
65                  70                  75                  80  


Phe Pro Val Tyr Gln Lys Lys Val Ile Asp Glu Trp Ala Pro Glu Glu 
                85                  90                  95      


Asp Gly Glu Glu Glu Glu Glu Glu Asp Glu Arg Asp Gln Arg Gly Tyr 
            100                 105                 110         


Arg Asp Asp Arg Ser Pro Ala Arg Glu Pro Gly Asp Val Ser Ala Arg 
        115                 120                 125             


Thr Arg Ser Gly Gly Gly Gly Gly Arg Ser Ala Thr Thr Ala Met Pro 
    130                 135                 140                 


Pro Pro Val Pro Asn Gly Asn Leu His Gln His Asp Pro Gln Asp Leu 
145                 150                 155                 160 


Arg His Asn Gly Asn Val Val Val Ala Gly Arg Pro Ser Cys Ser Arg 
                165                 170                 175     


Gly Pro Arg Arg Ala Ile Gln Lys Pro Gln Pro Ala Gly Gly Arg Arg 
            180                 185                 190         


Ser Gly Arg Gly Pro Ala Ala Gly Gly Leu Cys Leu Gln Pro Pro Asp 
        195                 200                 205             


Gly Gly Thr Cys Val Pro Glu Glu Pro Pro Val Pro Pro Met Asp Trp 
    210                 215                 220                 


Glu Ala Leu Glu Lys His Leu Ala Gly Leu Gln Phe Arg Glu Gln Glu 
225                 230                 235                 240 


Val Arg Asn Gln Gly Gln Ala Arg Thr Asn Ser Thr Ser Ala Gln Lys 
                245                 250                 255     


Asn Glu Arg Glu Ser Ile Arg Gln Lys Leu Ala Leu Gly Ser Phe Phe 
            260                 265                 270         


Asp Asp Gly Pro Gly Ile Tyr Thr Ser Cys Ser Lys Ser Gly Lys Pro 
        275                 280                 285             


Ser Leu Ser Ser Arg Leu Gln Ser Gly Met Asn Leu Gln Ile Cys Phe 
    290                 295                 300                 


Val Asn Asp Ser Gly Ser Asp Lys Asp Ser Asp Ala Asp Asp Ser Lys 
305                 310                 315                 320 


Thr Glu Thr Ser Leu Asp Thr Pro Leu Ser Pro Met Ser Lys Gln Ser 
                325                 330                 335     


Ser Ser Tyr Ser Asp Arg Asp Thr Thr Glu Glu Glu Ser Glu Ser Leu 
            340                 345                 350         


Asp Asp Met Asp Phe Leu Thr Arg Gln Lys Lys Leu Gln Ala Glu Ala 
        355                 360                 365             


Lys Met Ala Leu Ala Met Ala Lys Pro Met Ala Lys Met Gln Val Glu 
    370                 375                 380                 


Val Glu Lys Gln Asn Arg Lys Lys Ser Pro Val Ala Asp Leu Leu Pro 
385                 390                 395                 400 


His Met Pro His Ile Ser Glu Cys Leu Met Lys Arg Ser Leu Lys Pro 
                405                 410                 415     


Thr Asp Leu Arg Asp Met Thr Ile Gly Gln Leu Gln Val Ile Val Asn 
            420                 425                 430         


Asp Leu His Ser Gln Ile Glu Ser Leu Asn Glu Glu Leu Val Gln Leu 
        435                 440                 445             


Leu Leu Ile Arg Asp Glu Leu His Thr Glu Gln Asp Ala Met Leu Val 
    450                 455                 460                 


Asp Ile Glu Asp Leu Thr Arg His Ala Glu Ser Gln Gln Lys His Met 
465                 470                 475                 480 


Ala Glu Lys Met Pro Ala Lys 
                485         


<210>  879
<211>  1444
<212>  DNA
<213>  Homosapiens

<400>  879
tttcattttg ggccgagctg gaggcggcgg ggccgtcccg gaacggctgc ggccgggcac     60

cccgggagtt aatccgaaag cgccgcaagc cccgcgggcc ggccgcaccg cacgtgtcac    120

cgagaagctg atgtagagag agacacagaa ggagacagaa agcaagagac cagagtcccg    180

ggaaagtcct gccgcgcctc gggacaatta taaaaatgtg gccccctggg tcagcctccc    240

agccaccgcc ctcacctgcc gcggccacag gtctgcatcc agcggctcgc cctgtgtccc    300

tgcagtgccg gctcagcatg tgtccagcgc gcagcctcct ccttgtggct accctggtcc    360

tcctggacca cctcagtttg gccagaaacc tccccgtggc cactccagac ccaggaatgt    420

tcccatgcct tcaccactcc caaaacctgc tgagggccgt cagcaacatg ctccagaagg    480

ccagacaaac tctagaattt tacccttgca cttctgaaga gattgatcat gaagatatca    540

caaaagataa aaccagcaca gtggaggcct gtttaccatt ggaattaacc aagaatgaga    600

gttgcctaaa ttccagagag acctctttca taactaatgg gagttgcctg gcctccagaa    660

agacctcttt tatgatggcc ctgtgcctta gtagtattta tgaagacttg aagatgtacc    720

aggtggagtt caagaccatg aatgcaaagc ttctgatgga tcctaagagg cagatctttc    780

tagatcaaaa catgctggca gttattgatg agctgatgca ggccctgaat ttcaacagtg    840

agactgtgcc acaaaaatcc tcccttgaag aaccggattt ttataaaact aaaatcaagc    900

tctgcatact tcttcatgct ttcagaattc gggcagtgac tattgataga gtgatgagct    960

atctgaatgc ttcctaaaaa gcgaggtccc tccaaaccgt tgtcattttt ataaaacttt   1020

gaaatgagga aactttgata ggatgtggat taagaactag ggagggggaa agaaggatgg   1080

gactattaca tccacatgat acctctgatc aagtattttt gacatttact gtggataaat   1140

tgtttttaag ttttcatgaa tgaattgcta agaagggaaa atatccatcc tgaaggtgtt   1200

tttcattcac tttaatagaa gggcaaatat ttataagcta tttctgtacc aaagtgtttg   1260

tggaaacaaa catgtaagca taacttattt taaaatattt atttatataa cttggtaatc   1320

atgaaagcat ctgagctaac ttatatttat ttatgttata tttattaaat tatttatcaa   1380

gtgtatttga aaaatatttt taagtgttct aaaaataaaa gtattgaatt aaagtgaaaa   1440

aaaa                                                                1444


<210>  880
<211>  253
<212>  PRT
<213>  Homosapiens

<400>  880

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210>  881
<211>  4928
<212>  DNA
<213>  Homosapiens

<400>  881
acagtagaaa gtcagaaggt cacaaagctt gcagggtaag tgacacaact tgaaactgct     60

tggccctctt taaaaagaaa taataaaatg ggagagaatg aagcaagttt acctaacacg    120

tctttgcaag gtaaaaagat ggcctatcag aaggtccatg cagatcaaag agctccagga    180

cactcacagt acttagacaa tgatgacctt caagccactg cccttgactt agagtgggac    240

atggagaagg aactagagga gtctggtttt gaccaattcc agctagacgg tgctgagaat    300

cagaacctag ggcattcaga gactatagac ctcaatcttg attccattca accagcaact    360

tcacccaaag gaaggttcca gagacttcaa gaagaatctg actacattac ccattataca    420

cgatctgcac caaagagcaa tcgctgcaac ttttgccacg tcttaaaaat actttgcaca    480

gccaccattt tatttatttt tgggattttg ataggttatt atgtacatac aaattgccct    540

tcagatgctc catcttcagg aacagttgat cctcagttat atcaagagat tctcaagaca    600

atccaggcag aagatattaa gaagtctttc agaaatttgg tacaactata taaaaatgaa    660

gatgacacgg aaatttcaaa gaagattaag actcagtgga cctctttggg cctagaagat    720

gtacagtttg taaattactc tgtgctgctt gatctgccag gcccttctcc cagcactgtg    780

actctgagca gcagtggtca atgctttcat cctaatggcc agccttgcag tgaagaagcc    840

agaaaagata gcagccaaga cctgctctat tcatatgcag cctattctgc caaaggaact    900

ctcaaggctg aagtcatcga tgtgagttat ggaatggcag atgatttaaa aaggattagg    960

aaaataaaaa acgtaacaaa tcagatcgca ctcctgaaat taggaaaatt gccactgctt   1020

tataagcttt cctcattgga aaaggctgga tttggaggtg ttcttctgta tatcgatcct   1080

tgtgatttgc caaagactgt gaatcctagc catgatacct tcatggtgtc actgaatcca   1140

ggaggagacc cttctacgcc tggttaccca agtgtcgatg aaagttttag acaaagccga   1200

tcaaacctca cctctctatt agtgcagccc atctctgcat ccctcgttgc aaaactgatc   1260

tcttcgccaa aagctagaac caaaaatgaa gcgtgtagct ctctagagct tccaaataat   1320

gaaataagag tcgtcagcat gcaagttcag acagtcacaa aattgaaaac agttactaat   1380

gttgttggat ttgtaatggg cttgacatct ccagaccggt atatcatagt tggcagccat   1440

catcacactg cacacagtta taatggacaa gaatgggcca gtagtactgc aataatcaca   1500

gcgtttatcc gtgccttgat gtcaaaagtt aagagagggt ggagaccaga ccgaactatt   1560

gttttctgtt cttggggagg aacagctttt ggcaatattg gctcatatga atggggagag   1620

gatttcaaga aggttcttca aaaaaatgtt gtggcttata ttagcctcca cagtcccata   1680

agggggaact ctagtctgta tcctgtagca tcaccatctc ttcagcaact ggtagtagag   1740

aaaaataatt tcaactgtac cagaagagcc cagtgcccag aaaccaatat cagttctata   1800

cagatacaag gtgatgctga ttatttcatc aaccatcttg gagttcccat cgtgcagttt   1860

gcttacgagg acatcaaaac attagagggt ccaagttttc tctccgaggc ccgtttttct   1920

acacgagcaa caaaaattga agaaatggat cgctctttca accttcatga aaccattact   1980

aagctctcag gagaagtgat tttgcaaatt gccaacgaac ctgttctgcc ctttaatgca   2040

cttgatatag ctttagaagt tcaaaacaac cttaaaggtg atcaacccaa cactcatcaa   2100

ctgttagcca tggcgtcacg cctgcgggag agtgctgaac tttttcagtc tgatgagatg   2160

cgacctgcta atgatcccaa ggagagagca cccatccgca tccggatgct gaatgacatt   2220

ctccaagaca tggagaaaag ctttctggta aagcaggcac caccaggttt ttatagaaac   2280

atcctctacc accttgatga aaagacaagc cggttttcaa tacttataga ggcttgggaa   2340

cactgcaaac cccttgcatc aaatgagacc cttcaagaag ccctgtcaga ggtgttgaac   2400

agcattaatt cagctcaggt ttacttcaaa gcaggacttg atgtgttcaa gagtgtcttg   2460

gatgggaaga attgagaaaa ctctgagcat ttttaaaagt ttgtttacaa ttccacaagc   2520

aaaagctcta atttaaccag attttctgac attgaaggct tattttcccc aatggctttt   2580

tgacaagtat aaagctatta ttacattgta ttttttaaat gtaaatatag aaagaacatt   2640

ttgcacattt aatatttttc ttatatctac atttctgaat atgtaaagca agttattgaa   2700

ataggactta agaattacct attaaaaaga aatctgatat ataaaaatat gtactatttt   2760

aaggaaaaat ttccaagaag ttctggacta tctttgttcc tatggggagg gcatatagga   2820

acacagttta ttctctctga tagagctatt aatgacttag tttctgtaaa agaaatggag   2880

agttgatatg gttcagatta acttcactat taagtgttca atatgaagaa ttcaagtatt   2940

ctgactgagt gattggttga cctaaaccac tttgaatgtt tctattttat gagatgaagt   3000

ttctcttctt aacacaacta gatgtagtaa tacactggtt atgaaattgt atttttttaa   3060

gtattaatga aaaaagagcc ataagcattc caggggaaaa tctcaaggga gctacataga   3120

gcaatttaaa tgcaaatttt tttcctaaca acttacaagg tgactagctt tgaaacccct   3180

aatttgcctc agttgatttt ctaagaattt caggagtgat gtatgtctta agagggagaa   3240

aaaaatattt cttattactt tttctcttgt ttctgttgga aacactgaag cagggactct   3300

aaaatgaaag catctcacat tggttttctt tcttgtatct tttctgaaac tccttgctgt   3360

aaggcagctt tctcagagta ctatatattt ccaacagtaa agtagcagag tttctctttg   3420

aaacccaaaa tgtcttctaa agaatcaaat ttctatttct gcctctgaca aaaagaactt   3480

actatgaaag aaatagttgt tttatcaata aaagcccctt aatattatga agaaactttt   3540

catatttttt cttctttatc cttaattgtg actaagatgg aaatctagaa aatattcatg   3600

cttctaagtt tctgcagtgt tactgtaaga gagtgtctcg tctacacttc agttcttctc   3660

tcatgtggaa aactaagctt tttatattga cattgccatt gaatagctct agcaactatt   3720

attattcccc caaaccctaa aattctacct attaggtgtc aggttaaagt tctaatttat   3780

ctttagaaat ttatgtgaaa aatggttttc ctatactgga taaagcaatt ccccttagga   3840

aacatagcct cagagtattt catataaatt ttctctatct aattcaaaca tatctcccca   3900

tgatacaccg ccagagtgac attgcagaca gtctgtgtat gtttaaattt tcacttttta   3960

tggatgagca taaacctagt cttagtttaa aggcaaacta aagttgaggg gaaataatta   4020

atcaatactg attaattgat ttataaggtt caacactgtc taccctaaat aatttttata   4080

tgctcaaggc aaagcaggga atagaggcaa ttagctagat aattcaagca gaaatccatt   4140

ttcatcgaaa ttgcctgtgt gcacatattt ttagatgaaa aatgaaacta ccttacaata   4200

ttattttttt aatcaatgta tttgtttgca aacatttgcc atgttgaaga gtgtgtatag   4260

gaaaggtcta gaaataaata ggcttgtgca tacctaggca ttcatgctct ttcttcctct   4320

tcagagatca tcagaaaaga ggtgggaata cacaagcagg tgcatgtaag cccaaaagct   4380

agaaagcctt atatttaacc aaaggttgat gtgttcattc cagttattca cttacagatg   4440

aaactaaaac aaataaaggc aagctattat cagtttggta gttcgttatt ttagaacaaa   4500

tttctaaatg aatttattcc cataacctac aatagcactg agaacagaaa acatgtttct   4560

tcttcatttt gtttaaagat tgcgtaccta ggtaagtcac actgtataga taaaaacctt   4620

cttctgtatt cctcacctct aaattatatg ttatttgcta tttgaaaact gtagttaact   4680

atggtttttt attagtctat taaaagatac gtggagatat taaattatac ctaaagcaga   4740

cgtccaacaa attctgtaca tgctgcttta catctttgca acaaacctct taactagcag   4800

cattatttct atagtgtgat tacctgaggg tgcctccaaa tgtatatcat ttcactcccc   4860

tcccctcccc acccccaata gattcaaata aataaaatcc tgagcaaatt aaaaaaaaaa   4920

aaaaaaaa                                                            4928


<210>  882
<211>  795
<212>  PRT
<213>  Homosapiens

<400>  882

Met Gly Glu Asn Glu Ala Ser Leu Pro Asn Thr Ser Leu Gln Gly Lys 
1               5                   10                  15      


Lys Met Ala Tyr Gln Lys Val His Ala Asp Gln Arg Ala Pro Gly His 
            20                  25                  30          


Ser Gln Tyr Leu Asp Asn Asp Asp Leu Gln Ala Thr Ala Leu Asp Leu 
        35                  40                  45              


Glu Trp Asp Met Glu Lys Glu Leu Glu Glu Ser Gly Phe Asp Gln Phe 
    50                  55                  60                  


Gln Leu Asp Gly Ala Glu Asn Gln Asn Leu Gly His Ser Glu Thr Ile 
65                  70                  75                  80  


Asp Leu Asn Leu Asp Ser Ile Gln Pro Ala Thr Ser Pro Lys Gly Arg 
                85                  90                  95      


Phe Gln Arg Leu Gln Glu Glu Ser Asp Tyr Ile Thr His Tyr Thr Arg 
            100                 105                 110         


Ser Ala Pro Lys Ser Asn Arg Cys Asn Phe Cys His Val Leu Lys Ile 
        115                 120                 125             


Leu Cys Thr Ala Thr Ile Leu Phe Ile Phe Gly Ile Leu Ile Gly Tyr 
    130                 135                 140                 


Tyr Val His Thr Asn Cys Pro Ser Asp Ala Pro Ser Ser Gly Thr Val 
145                 150                 155                 160 


Asp Pro Gln Leu Tyr Gln Glu Ile Leu Lys Thr Ile Gln Ala Glu Asp 
                165                 170                 175     


Ile Lys Lys Ser Phe Arg Asn Leu Val Gln Leu Tyr Lys Asn Glu Asp 
            180                 185                 190         


Asp Thr Glu Ile Ser Lys Lys Ile Lys Thr Gln Trp Thr Ser Leu Gly 
        195                 200                 205             


Leu Glu Asp Val Gln Phe Val Asn Tyr Ser Val Leu Leu Asp Leu Pro 
    210                 215                 220                 


Gly Pro Ser Pro Ser Thr Val Thr Leu Ser Ser Ser Gly Gln Cys Phe 
225                 230                 235                 240 


His Pro Asn Gly Gln Pro Cys Ser Glu Glu Ala Arg Lys Asp Ser Ser 
                245                 250                 255     


Gln Asp Leu Leu Tyr Ser Tyr Ala Ala Tyr Ser Ala Lys Gly Thr Leu 
            260                 265                 270         


Lys Ala Glu Val Ile Asp Val Ser Tyr Gly Met Ala Asp Asp Leu Lys 
        275                 280                 285             


Arg Ile Arg Lys Ile Lys Asn Val Thr Asn Gln Ile Ala Leu Leu Lys 
    290                 295                 300                 


Leu Gly Lys Leu Pro Leu Leu Tyr Lys Leu Ser Ser Leu Glu Lys Ala 
305                 310                 315                 320 


Gly Phe Gly Gly Val Leu Leu Tyr Ile Asp Pro Cys Asp Leu Pro Lys 
                325                 330                 335     


Thr Val Asn Pro Ser His Asp Thr Phe Met Val Ser Leu Asn Pro Gly 
            340                 345                 350         


Gly Asp Pro Ser Thr Pro Gly Tyr Pro Ser Val Asp Glu Ser Phe Arg 
        355                 360                 365             


Gln Ser Arg Ser Asn Leu Thr Ser Leu Leu Val Gln Pro Ile Ser Ala 
    370                 375                 380                 


Ser Leu Val Ala Lys Leu Ile Ser Ser Pro Lys Ala Arg Thr Lys Asn 
385                 390                 395                 400 


Glu Ala Cys Ser Ser Leu Glu Leu Pro Asn Asn Glu Ile Arg Val Val 
                405                 410                 415     


Ser Met Gln Val Gln Thr Val Thr Lys Leu Lys Thr Val Thr Asn Val 
            420                 425                 430         


Val Gly Phe Val Met Gly Leu Thr Ser Pro Asp Arg Tyr Ile Ile Val 
        435                 440                 445             


Gly Ser His His His Thr Ala His Ser Tyr Asn Gly Gln Glu Trp Ala 
    450                 455                 460                 


Ser Ser Thr Ala Ile Ile Thr Ala Phe Ile Arg Ala Leu Met Ser Lys 
465                 470                 475                 480 


Val Lys Arg Gly Trp Arg Pro Asp Arg Thr Ile Val Phe Cys Ser Trp 
                485                 490                 495     


Gly Gly Thr Ala Phe Gly Asn Ile Gly Ser Tyr Glu Trp Gly Glu Asp 
            500                 505                 510         


Phe Lys Lys Val Leu Gln Lys Asn Val Val Ala Tyr Ile Ser Leu His 
        515                 520                 525             


Ser Pro Ile Arg Gly Asn Ser Ser Leu Tyr Pro Val Ala Ser Pro Ser 
    530                 535                 540                 


Leu Gln Gln Leu Val Val Glu Lys Asn Asn Phe Asn Cys Thr Arg Arg 
545                 550                 555                 560 


Ala Gln Cys Pro Glu Thr Asn Ile Ser Ser Ile Gln Ile Gln Gly Asp 
                565                 570                 575     


Ala Asp Tyr Phe Ile Asn His Leu Gly Val Pro Ile Val Gln Phe Ala 
            580                 585                 590         


Tyr Glu Asp Ile Lys Thr Leu Glu Gly Pro Ser Phe Leu Ser Glu Ala 
        595                 600                 605             


Arg Phe Ser Thr Arg Ala Thr Lys Ile Glu Glu Met Asp Arg Ser Phe 
    610                 615                 620                 


Asn Leu His Glu Thr Ile Thr Lys Leu Ser Gly Glu Val Ile Leu Gln 
625                 630                 635                 640 


Ile Ala Asn Glu Pro Val Leu Pro Phe Asn Ala Leu Asp Ile Ala Leu 
                645                 650                 655     


Glu Val Gln Asn Asn Leu Lys Gly Asp Gln Pro Asn Thr His Gln Leu 
            660                 665                 670         


Leu Ala Met Ala Ser Arg Leu Arg Glu Ser Ala Glu Leu Phe Gln Ser 
        675                 680                 685             


Asp Glu Met Arg Pro Ala Asn Asp Pro Lys Glu Arg Ala Pro Ile Arg 
    690                 695                 700                 


Ile Arg Met Leu Asn Asp Ile Leu Gln Asp Met Glu Lys Ser Phe Leu 
705                 710                 715                 720 


Val Lys Gln Ala Pro Pro Gly Phe Tyr Arg Asn Ile Leu Tyr His Leu 
                725                 730                 735     


Asp Glu Lys Thr Ser Arg Phe Ser Ile Leu Ile Glu Ala Trp Glu His 
            740                 745                 750         


Cys Lys Pro Leu Ala Ser Asn Glu Thr Leu Gln Glu Ala Leu Ser Glu 
        755                 760                 765             


Val Leu Asn Ser Ile Asn Ser Ala Gln Val Tyr Phe Lys Ala Gly Leu 
    770                 775                 780                 


Asp Val Phe Lys Ser Val Leu Asp Gly Lys Asn 
785                 790                 795 


<210>  883
<211>  1210
<212>  DNA
<213>  Homosapiens

<400>  883
agcacgatgg aatctggtgg cttaaaccta gctgtccaca tttcactatc tgaagagcag     60

aaaatgtgtt aataggagcc tggtgagtgg aggagactga agatggagag agagcctgga    120

cctcaacatg agcatctgga gccatttggc agcattaggc tgtgaccgct tagagaaccg    180

aaaggtgcag agctttaaag gattatggag tctgaagacc aaatgggatg atggagaaca    240

gctattcagt ggtacaaatg taaatgctcc caggcccggg cagaaaagag aaaacatttc    300

catggaagag gaaacaggaa attccaacag atcagcaaca gttggagtgc taacctgtca    360

ctggaatggg aaaaaaaatg ctgtcgttga cacatctttt ccttgttttt gacacaaatt    420

agaaacacca cctggaacac agctgtgact tgataaacaa gtgaaacatt ctttggtgtg    480

gtgaggggaa aacaaatttc tcaaaggaca cgcaccatgg tgtatgagag gacactggag    540

cccagccagc atctgacatg ctgaattcaa agtgcaggtg aaagtaggac aactgattca    600

caagctggga tgcctgtgtt gttgtttgcc agtgtgcgtg tgtgtgtttt cctggcaccc    660

ttcattcatt ccccagcaca gttgacatca ggttggaagc agtgagttct gagggagact    720

gctagaggac ccaacttgga gaatcaacga tctgcgatga agataatgaa gataaagaca    780

atgtcaatgt cagcgtccaa aatcataagg accctttaag aagcttccag agcagaagtg    840

actgtgcaag aagggccaat aaagtctagg caatgcacga ccaggcgcgg tcgctcacgc    900

ctgtaatccc agcactttgg gaggccgagg tggttggatt acctgaggtt aggagtttga    960

gaccagcctg accaacatag tttcacccca tctctactaa aaaaaaaaaa aaaaacaaaa   1020

caaaagttag ccaggtgtgg tgctgcacac ctgtaatccc agctactctg gaagctgagg   1080

caggagaatc gcttgaaccc aggaggcgga ggtggcagtg agctgagatt gcaccgctgc   1140

actccagcct gggcgacaga gtgagactct gtctcaaaaa taaataaata aataaataat   1200

aaagtctagg                                                          1210


<210>  884
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  884

Met Ser Ile Trp Ser His Leu Ala Ala Leu Gly Cys Asp Arg Leu Glu 
1               5                   10                  15      


Asn Arg Lys Val Gln Ser Phe Lys Gly Leu Trp Ser Leu Lys Thr Lys 
            20                  25                  30          


Trp Asp Asp Gly Glu Gln Leu Phe Ser Gly Thr Asn Val Asn Ala Pro 
        35                  40                  45              


Arg Pro Gly Gln Lys Arg Glu Asn Ile Ser Met Glu Glu Glu Thr Gly 
    50                  55                  60                  


Asn Ser Asn Arg Ser Ala Thr Val Gly Val Leu Thr Cys His Trp Asn 
65                  70                  75                  80  


Gly Lys Lys Asn Ala Val Val Asp Thr Ser Phe Pro Cys Phe 
                85                  90                  


<210>  885
<211>  2832
<212>  DNA
<213>  Homosapiens

<400>  885
cttccgcttc ctgtaccacc ctgctcaagt agcggacacg gaacagggaa ctatcagccc     60

gtcggcctcc gggccctgca ttctctagcc atggaccggg accttttgcg gcagtcgcta    120

aattgccacg ggtcgtcttt gctctctcta cttcggagcg aacagcagga caatccacac    180

ttccgtagcc tcctggggtc ggccgccgag ccagcccggg gcccgccgcc ccagcacccg    240

ttgcagggca gaaaagagaa gagagttgac aacatcgaga tacagaaatt catctccaaa    300

aaagcggatc tgctttttgc actttcctgg aaatcagatg cacctgcaac ttctgaaatt    360

aatgaagaca gtgaagatca ttatgcaatc atgccacctt tagagcaatt catggagata    420

cctagtatgg atcggagaga gctgtttttc cgagatattg agcgtggtga tatagtgatt    480

ggaagaatta gttctattcg ggaattcggt tttttcatgg tgttgatctg tttaggaagt    540

ggtatcatga gagatatagc ccacttagaa atcacagctc tttgtccctt aagagatgtg    600

ccttctcaca gtaaccatgg ggatccttta tcatattacc aaactggtga catcattcga    660

gctggaatca aggatattga cagataccat gaaaagctag cagtatctct gtatagctct    720

tctcttccac cacacctatc tggtattaaa ttaggtgtaa ttagctctga agagcttcct    780

ttatactaca ggagaagtgt tgagctaaat agcaattctt tggagtccta tgaaaatgtc    840

atgcagagtt ccttgggatt tgttaatcca ggagtagttg aattccttct agaaaaacta    900

ggaatagatg aatctaatcc accatcttta atgagaggcc tacaaagcaa aaatttctct    960

gaagatgatt ttgcttctgc attgagaaaa aaacaatccg catcttgggc tttaaaatgt   1020

gtgaagatcg gagttgacta ttttaaagtt ggacgccatg tggatgctat gaatgaatac   1080

aataaagctt tggaaataga caaacaaaac gtggaagctt tggtagctcg tggagcatta   1140

tatgcgacaa aaggaagttt gaacaaagca atagaagatt ttgagcttgc attagaaaac   1200

tgtccaactc acagaaatgc aagaaaatac ctctgccaga cacttgtaga gagaggagga   1260

cagttagaag aagaagaaaa gtttttaaat gctgaaagtt actataagaa agccttggct   1320

ttggatgaga cttttaaaga tgcagaggat gctttgcaga aacttcataa atatatgcag   1380

aaatctttgg aattaagaga aaaacaagct gaaaaggaag aaaagcagaa aacaaagaaa   1440

atagaaacaa gtgcagaaaa gttgcgtaag ctcttaaaag aagagaagag gctaaagaag   1500

aaaagaagaa aatcaacttc ttcttcaagt gtttcttctg ctgatgaatc agtgtcttca   1560

tcatcatcct cttcctcttc tggtcacaaa aggcataaga aacataagag gaaccgttca   1620

gagtcttctc gcagttccag aaggcattca tctagggcat cctcaaatca gatagatcag   1680

aataggaaag atgagtgcta cccagttcca gctaatactt cagcatcttt tcttaaccat   1740

aaacaagaag tggagaaact actggggaag caggataggt tacagtatga aaagacacag   1800

ataaaagaga aagatagatg ccctctctct tcatcttcac ttgaaatacc ggatgatttt   1860

ggaggtaggt ctgaagatcc aagagatttt tataacagct ataaaaccca agcaggtagt   1920

agcaaaacag aaaagccata taaatcagaa agacattttt ccagtagaag aaattcctca   1980

gattccttct gtaggaattc agaggacaag atttatggtt ataggagatt tgaaaaggat   2040

atagagggaa gaaaagagca ctatagaagg tgggaaccag gttctgtgag gcattctacc   2100

tcaccagcaa gctcagaata ctcttggaag tcagttgaga aatacaaaaa atacgctcac   2160

tctggatcac gtgatttcag tagacatgag caaagatacc gtttaaatac aaatcaagga   2220

gaatatgaaa gagaggacaa ttatggggag gatatcaaaa cagaggttcc agaagaagat   2280

gcactaagta gcaaagaaca ctcagaaagc agtgttaaga aaaatttacc tcagaattta   2340

ctgaatatat ttaatcagat agctgaattt gaaaaagaaa aaggaaataa gtcaaaaaat   2400

taatacacca aggatatcgg caccattaca caaaatgcca ttaagtgaag tttttggttg   2460

tattagtcat aacagttgag tgcagaaatc tctgcttcta aaattatttg tagagattac   2520

aggaaacaaa tgcttttaag taagtttctc tcaaattttg tttcagttct aggtcccttg   2580

tcacagcttg gtttttagac tttttatgta tatgtttatg tacagtatat tactcttgac   2640

agtttgaatt tcttcaccta aagataattc tctgaaagta ctgtttcttc attctattgc   2700

ggtatatgag aattcctggg tgcatcttat tctgctgttt gagagaaaaa tttgtgcatt   2760

gaacacttgg atcattttta taaaaattaa tttcattttc ttttctgtta aattaaaaat   2820

cgtcagcttt tg                                                       2832


<210>  886
<211>  770
<212>  PRT
<213>  Homosapiens

<400>  886

Met Asp Arg Asp Leu Leu Arg Gln Ser Leu Asn Cys His Gly Ser Ser 
1               5                   10                  15      


Leu Leu Ser Leu Leu Arg Ser Glu Gln Gln Asp Asn Pro His Phe Arg 
            20                  25                  30          


Ser Leu Leu Gly Ser Ala Ala Glu Pro Ala Arg Gly Pro Pro Pro Gln 
        35                  40                  45              


His Pro Leu Gln Gly Arg Lys Glu Lys Arg Val Asp Asn Ile Glu Ile 
    50                  55                  60                  


Gln Lys Phe Ile Ser Lys Lys Ala Asp Leu Leu Phe Ala Leu Ser Trp 
65                  70                  75                  80  


Lys Ser Asp Ala Pro Ala Thr Ser Glu Ile Asn Glu Asp Ser Glu Asp 
                85                  90                  95      


His Tyr Ala Ile Met Pro Pro Leu Glu Gln Phe Met Glu Ile Pro Ser 
            100                 105                 110         


Met Asp Arg Arg Glu Leu Phe Phe Arg Asp Ile Glu Arg Gly Asp Ile 
        115                 120                 125             


Val Ile Gly Arg Ile Ser Ser Ile Arg Glu Phe Gly Phe Phe Met Val 
    130                 135                 140                 


Leu Ile Cys Leu Gly Ser Gly Ile Met Arg Asp Ile Ala His Leu Glu 
145                 150                 155                 160 


Ile Thr Ala Leu Cys Pro Leu Arg Asp Val Pro Ser His Ser Asn His 
                165                 170                 175     


Gly Asp Pro Leu Ser Tyr Tyr Gln Thr Gly Asp Ile Ile Arg Ala Gly 
            180                 185                 190         


Ile Lys Asp Ile Asp Arg Tyr His Glu Lys Leu Ala Val Ser Leu Tyr 
        195                 200                 205             


Ser Ser Ser Leu Pro Pro His Leu Ser Gly Ile Lys Leu Gly Val Ile 
    210                 215                 220                 


Ser Ser Glu Glu Leu Pro Leu Tyr Tyr Arg Arg Ser Val Glu Leu Asn 
225                 230                 235                 240 


Ser Asn Ser Leu Glu Ser Tyr Glu Asn Val Met Gln Ser Ser Leu Gly 
                245                 250                 255     


Phe Val Asn Pro Gly Val Val Glu Phe Leu Leu Glu Lys Leu Gly Ile 
            260                 265                 270         


Asp Glu Ser Asn Pro Pro Ser Leu Met Arg Gly Leu Gln Ser Lys Asn 
        275                 280                 285             


Phe Ser Glu Asp Asp Phe Ala Ser Ala Leu Arg Lys Lys Gln Ser Ala 
    290                 295                 300                 


Ser Trp Ala Leu Lys Cys Val Lys Ile Gly Val Asp Tyr Phe Lys Val 
305                 310                 315                 320 


Gly Arg His Val Asp Ala Met Asn Glu Tyr Asn Lys Ala Leu Glu Ile 
                325                 330                 335     


Asp Lys Gln Asn Val Glu Ala Leu Val Ala Arg Gly Ala Leu Tyr Ala 
            340                 345                 350         


Thr Lys Gly Ser Leu Asn Lys Ala Ile Glu Asp Phe Glu Leu Ala Leu 
        355                 360                 365             


Glu Asn Cys Pro Thr His Arg Asn Ala Arg Lys Tyr Leu Cys Gln Thr 
    370                 375                 380                 


Leu Val Glu Arg Gly Gly Gln Leu Glu Glu Glu Glu Lys Phe Leu Asn 
385                 390                 395                 400 


Ala Glu Ser Tyr Tyr Lys Lys Ala Leu Ala Leu Asp Glu Thr Phe Lys 
                405                 410                 415     


Asp Ala Glu Asp Ala Leu Gln Lys Leu His Lys Tyr Met Gln Lys Ser 
            420                 425                 430         


Leu Glu Leu Arg Glu Lys Gln Ala Glu Lys Glu Glu Lys Gln Lys Thr 
        435                 440                 445             


Lys Lys Ile Glu Thr Ser Ala Glu Lys Leu Arg Lys Leu Leu Lys Glu 
    450                 455                 460                 


Glu Lys Arg Leu Lys Lys Lys Arg Arg Lys Ser Thr Ser Ser Ser Ser 
465                 470                 475                 480 


Val Ser Ser Ala Asp Glu Ser Val Ser Ser Ser Ser Ser Ser Ser Ser 
                485                 490                 495     


Ser Gly His Lys Arg His Lys Lys His Lys Arg Asn Arg Ser Glu Ser 
            500                 505                 510         


Ser Arg Ser Ser Arg Arg His Ser Ser Arg Ala Ser Ser Asn Gln Ile 
        515                 520                 525             


Asp Gln Asn Arg Lys Asp Glu Cys Tyr Pro Val Pro Ala Asn Thr Ser 
    530                 535                 540                 


Ala Ser Phe Leu Asn His Lys Gln Glu Val Glu Lys Leu Leu Gly Lys 
545                 550                 555                 560 


Gln Asp Arg Leu Gln Tyr Glu Lys Thr Gln Ile Lys Glu Lys Asp Arg 
                565                 570                 575     


Cys Pro Leu Ser Ser Ser Ser Leu Glu Ile Pro Asp Asp Phe Gly Gly 
            580                 585                 590         


Arg Ser Glu Asp Pro Arg Asp Phe Tyr Asn Ser Tyr Lys Thr Gln Ala 
        595                 600                 605             


Gly Ser Ser Lys Thr Glu Lys Pro Tyr Lys Ser Glu Arg His Phe Ser 
    610                 615                 620                 


Ser Arg Arg Asn Ser Ser Asp Ser Phe Cys Arg Asn Ser Glu Asp Lys 
625                 630                 635                 640 


Ile Tyr Gly Tyr Arg Arg Phe Glu Lys Asp Ile Glu Gly Arg Lys Glu 
                645                 650                 655     


His Tyr Arg Arg Trp Glu Pro Gly Ser Val Arg His Ser Thr Ser Pro 
            660                 665                 670         


Ala Ser Ser Glu Tyr Ser Trp Lys Ser Val Glu Lys Tyr Lys Lys Tyr 
        675                 680                 685             


Ala His Ser Gly Ser Arg Asp Phe Ser Arg His Glu Gln Arg Tyr Arg 
    690                 695                 700                 


Leu Asn Thr Asn Gln Gly Glu Tyr Glu Arg Glu Asp Asn Tyr Gly Glu 
705                 710                 715                 720 


Asp Ile Lys Thr Glu Val Pro Glu Glu Asp Ala Leu Ser Ser Lys Glu 
                725                 730                 735     


His Ser Glu Ser Ser Val Lys Lys Asn Leu Pro Gln Asn Leu Leu Asn 
            740                 745                 750         


Ile Phe Asn Gln Ile Ala Glu Phe Glu Lys Glu Lys Gly Asn Lys Ser 
        755                 760                 765             


Lys Asn 
    770 


<210>  887
<211>  4535
<212>  DNA
<213>  Homosapiens

<400>  887
tacttttgta ttgtttaatt ttttttaaca gttgtcttgt tttttcttct gcagtgaaaa     60

taatggtgac aagaagccca ctgcctgatt cacataagca aggcatgctg cagggaagac    120

agggttctta ttaatatttc ctttcatgtg cttacatatg agttacagtt gctaatcctt    180

tcccacagtt tagcacctag ttaaaagaaa gggcttcgga atcaggtaag tgtagattaa    240

agttataacg gcaaattgct gaacctttgg aagcctcggt ttttccacct ggaaaatgga    300

tttttatctt acaggactgt cgtgaggatt gatgagctaa cattcctaaa tcagggagtt    360

tgaagtctgg cccagggtat tttcctcctt tcctgaaata atgtgtagtt ctgaccaagt    420

gagaagaatc ataagaatat gggattttga aaaacatgaa aacatcctaa gaaataccag    480

gaaggagtcc cacagtgaag cacaaatgaa actcaagatg actgcctaaa ataagaaatc    540

atggatctta ggagaaaggg ggcaaggaag taaatcaaag gacaaagctg aagaccaagt    600

ggaccgaaaa gaagatggaa tacattttcc caaacactgg tgttctctgg agttggctta    660

tcaacatctt gtgcaatcgg aggatcgtgt ggtttacttc cagccagctg ccccgtggtc    720

ctccagccag ctccgggggc cacagttttc acacgctccg ggagcgatcc gagagccgcc    780

ttttcgtgga aagttacgct gccgcctggc aacccccggg aacgtcggga ggggcaagtt    840

gctgctcatc cctcagtgct caagtcatga gtagcgaatt cctggctgag ctgcactggg    900

aggatgggtt cgccatcccg gtggcgaacg aggagaacaa gctactggaa gatcagttgt    960

caaagctgaa ggatgaaaga gcaagcttgc aagatgagtt acgtgagtat gaagagcgaa   1020

ttaattctat gacttctcac ttcaaaaatg ttaagcaaga gctctcaatt acacagtctc   1080

tttgcaaagc aagggagcgt gagactgaaa gtgaagaaca ttttaaggcc attgctcaaa   1140

gagaattggg acgagtgaaa gatgaaattc aacggctgga aaatgagatg gcttcaatac   1200

tggaaaagaa aagtgataaa gaaaatggca tatttaaagc cactcaaaaa ttggatggtt   1260

tgaaatgtca aatgaactgg gaccagcaag cattggaggc ctggttagaa gaatcagctc   1320

ataaagatag tgatgctctc actctccaga agtatgcaca acaagatgat aataaaatca   1380

gggcactgac tctgcaatta gaaagactaa ctttggaatg taatcagaaa agaaagatac   1440

ttgacaacga acttacagag actataagcg cacagttaga attggataaa gcagcacaag   1500

attttcgtaa gattcataat gaaagacaag aactcattaa acaatgggag aacacaatag   1560

aacagatgca gaagagggat ggagacatag ataactgtgc tttggaatta gcaaggataa   1620

agcaggaaac gagagaaaaa gaaaatttgg ttaaagaaaa gatcaagttt ttggaaagtg   1680

agattgggaa taacacagag tttgagaaaa gaatttctgt ggctgatcgt aaacttttaa   1740

aatgtagaac ggcatatcag gaccatgaaa ctagtagaat tcagctgaag ggtgagctgg   1800

attctttaaa agccactgtg aatagaactt ccagtgattt agaagctctg aggaaaaata   1860

tttccaagat aaagaaggac attcatgaag aaacagcaag gttacaaaaa actaaaaatc   1920

ataatgagat aatacaaaca aaattaaagg agataactga gaaaaccatg tctgtagaag   1980

agaaagctac taatttggaa gatatgctaa aggaggagga aaaagatgtg aaggaagtag   2040

atgttcaact gaacctcata aaaggtgtgc tgtttaagaa agctcaggag ttacagactg   2100

agacaatgaa agaaaaagct gttttatcag aaattgaagg aactcgttcc tctctgaaac   2160

atctcaacca tcagttacaa aaactggatt ttgaaacctt gaagcagcaa gaaattatgt   2220

acagccagga ttttcacatt caacaagtgg aacggagaat gtcacggtta aagggagaaa   2280

ttaattcaga agaaaaacaa gcgcttgaag caaaaattgt tgaacttagg aagtctttgg   2340

aagagaaaaa atctacatgt ggccttttgg aaacacagat caagaagctt cataatgatc   2400

tttattttat caagaaggca catagtaaaa acagtgatga aaaacagtcc cttatgacca   2460

aaataaatga actaaacctt ttcatcgaca gatcagagaa agaacttgat aaagccaaag   2520

gttttaagca ggatttgatg atagaggaca atcttttaaa acttgaagtt aagcgtactc   2580

gagaaatgct tcacagtaag gcagaagaag ttctttccct agaaaaaaga aaacagcaat   2640

tatacacagc aatggaagag cgaactgaag aaatcaaggt tcataaaaca atgcttgcgt   2700

cacaaataag atatgttgat caagaacggg aaaacataag cactgagttt cgcgagcggc   2760

taagtaaaat tgagaagctg aagaatagat atgaaattct gactgttgtt atgctgcctc   2820

ctgaaggaga agaggagaaa acacaggcct attatgtaat aaaggtgatg agtatgagct   2880

aaaaattcaa ctagaagaac aaaaaagagc tgttgatgaa aaatacagat acaaacaaag   2940

acaaatcaga gaacttcaag aagacatcca gagcatggaa aatacattag atgttataga   3000

acatttggca aataatgtta aagaaaagtt atcagagaag caggcttatt catttcaact   3060

aagtaaagaa acggaggagc agaagccaaa attagaaaga gtgaccaaac agtgtgcaaa   3120

actcacaaag gaaatccgtc ttttgaaaga cacaaaagat gaaacaatgg aagaacaaga   3180

catcaaactt cgtgaaatga aacagtttca caaagttatt gatgaaatgt tagttgatat   3240

catagaagaa aatactgaga tccgtattat ccttcaaaca tactttcaac agagtgggtt   3300

agaactacct acagctagca caaaaggcag tcgtcagagc tctagatctc cttcacatac   3360

ttcactatca gcaaggtcat ctaggagtac aagtacatct acttctcagt cttcaattaa   3420

agtactggag cttaaattcc cggcctcctc ttcactagta ggcagccctt ctaggccatc   3480

tagtgctagt agtagctcta gtaatgttaa gagcaaaaag agcagcaaat aaacatttta   3540

atctcttctg aaaaagttgt aaacacaaaa acaaaaatat actttaaaat acaaaacgac   3600

ccaacacatt ttatctagtg gaaagtgtaa aaacttagtg gtaagtgtaa aaactgatag   3660

ttttaaaaaa aaaggaacgt tctcattttc tctactgttt tcttcatact gaagaaatta   3720

atagcagatt cttgacaagg ctacatgtta tacaagcata ggaaaaatgc tgtatttcac   3780

tgtaattctg atgttcgtag tgttagaaaa tagtttgctt cattatttca cgaaactaca   3840

ctcacttcta atgtaacaat ctttcaagaa gaaatttcta aagatttact gtactattat   3900

gagcgtattg caatgtgaaa atctcattta ccctacaaga caccaaaatt aggttttctt   3960

tattcaaagt aactatttct cagacttttg gggagaaaaa ttgttaaagg cagtttcttc   4020

ttttgctata atttttaacc aaaaaatagc atcaacccct acccacccca cccccccaaa   4080

aaaaaaccgg taagagaaac actgtatatc aattttaaaa tgcagcataa atttagaaaa   4140

atcacttctg accttgaaat aaatcacttc tgaccttgaa ataaacgcat taaagatttg   4200

ctttcagata cagccaacca agtataaaca attttgaaat tttcttgatt taataaacga   4260

tttaatgaaa gctaggtatg acttgatttg caatagaaat ttcatttaca gttggaggta   4320

gactgccaaa tgtagtagtt tttccagtta acacttcatt ataacatgtg cccaacactt   4380

tgtactcttg gaatagagtg tggaatatta taaaactgga ttttaaataa atgtattaga   4440

attcacgaat gtacatgtgt ctccttcaaa ccttgggaaa aaatgctcat tacaactgtc   4500

attattttag aactgttgtt tgtacttctt tctga                              4535


<210>  888
<211>  755
<212>  PRT
<213>  Homosapiens

<400>  888

Met Glu Tyr Ile Phe Pro Asn Thr Gly Val Leu Trp Ser Trp Leu Ile 
1               5                   10                  15      


Asn Ile Leu Cys Asn Arg Arg Ile Val Trp Phe Thr Ser Ser Gln Leu 
            20                  25                  30          


Pro Arg Gly Pro Pro Ala Ser Ser Gly Gly His Ser Phe His Thr Leu 
        35                  40                  45              


Arg Glu Arg Ser Glu Ser Arg Leu Phe Val Glu Ser Tyr Ala Ala Ala 
    50                  55                  60                  


Trp Gln Pro Pro Gly Thr Ser Gly Gly Ala Ser Cys Cys Ser Ser Leu 
65                  70                  75                  80  


Ser Ala Gln Val Met Ser Ser Glu Phe Leu Ala Glu Leu His Trp Glu 
                85                  90                  95      


Asp Gly Phe Ala Ile Pro Val Ala Asn Glu Glu Asn Lys Leu Leu Glu 
            100                 105                 110         


Asp Gln Leu Ser Lys Leu Lys Asp Glu Arg Ala Ser Leu Gln Asp Glu 
        115                 120                 125             


Leu Arg Glu Tyr Glu Glu Arg Ile Asn Ser Met Thr Ser His Phe Lys 
    130                 135                 140                 


Asn Val Lys Gln Glu Leu Ser Ile Thr Gln Ser Leu Cys Lys Ala Arg 
145                 150                 155                 160 


Glu Arg Glu Thr Glu Ser Glu Glu His Phe Lys Ala Ile Ala Gln Arg 
                165                 170                 175     


Glu Leu Gly Arg Val Lys Asp Glu Ile Gln Arg Leu Glu Asn Glu Met 
            180                 185                 190         


Ala Ser Ile Leu Glu Lys Lys Ser Asp Lys Glu Asn Gly Ile Phe Lys 
        195                 200                 205             


Ala Thr Gln Lys Leu Asp Gly Leu Lys Cys Gln Met Asn Trp Asp Gln 
    210                 215                 220                 


Gln Ala Leu Glu Ala Trp Leu Glu Glu Ser Ala His Lys Asp Ser Asp 
225                 230                 235                 240 


Ala Leu Thr Leu Gln Lys Tyr Ala Gln Gln Asp Asp Asn Lys Ile Arg 
                245                 250                 255     


Ala Leu Thr Leu Gln Leu Glu Arg Leu Thr Leu Glu Cys Asn Gln Lys 
            260                 265                 270         


Arg Lys Ile Leu Asp Asn Glu Leu Thr Glu Thr Ile Ser Ala Gln Leu 
        275                 280                 285             


Glu Leu Asp Lys Ala Ala Gln Asp Phe Arg Lys Ile His Asn Glu Arg 
    290                 295                 300                 


Gln Glu Leu Ile Lys Gln Trp Glu Asn Thr Ile Glu Gln Met Gln Lys 
305                 310                 315                 320 


Arg Asp Gly Asp Ile Asp Asn Cys Ala Leu Glu Leu Ala Arg Ile Lys 
                325                 330                 335     


Gln Glu Thr Arg Glu Lys Glu Asn Leu Val Lys Glu Lys Ile Lys Phe 
            340                 345                 350         


Leu Glu Ser Glu Ile Gly Asn Asn Thr Glu Phe Glu Lys Arg Ile Ser 
        355                 360                 365             


Val Ala Asp Arg Lys Leu Leu Lys Cys Arg Thr Ala Tyr Gln Asp His 
    370                 375                 380                 


Glu Thr Ser Arg Ile Gln Leu Lys Gly Glu Leu Asp Ser Leu Lys Ala 
385                 390                 395                 400 


Thr Val Asn Arg Thr Ser Ser Asp Leu Glu Ala Leu Arg Lys Asn Ile 
                405                 410                 415     


Ser Lys Ile Lys Lys Asp Ile His Glu Glu Thr Ala Arg Leu Gln Lys 
            420                 425                 430         


Thr Lys Asn His Asn Glu Ile Ile Gln Thr Lys Leu Lys Glu Ile Thr 
        435                 440                 445             


Glu Lys Thr Met Ser Val Glu Glu Lys Ala Thr Asn Leu Glu Asp Met 
    450                 455                 460                 


Leu Lys Glu Glu Glu Lys Asp Val Lys Glu Val Asp Val Gln Leu Asn 
465                 470                 475                 480 


Leu Ile Lys Gly Val Leu Phe Lys Lys Ala Gln Glu Leu Gln Thr Glu 
                485                 490                 495     


Thr Met Lys Glu Lys Ala Val Leu Ser Glu Ile Glu Gly Thr Arg Ser 
            500                 505                 510         


Ser Leu Lys His Leu Asn His Gln Leu Gln Lys Leu Asp Phe Glu Thr 
        515                 520                 525             


Leu Lys Gln Gln Glu Ile Met Tyr Ser Gln Asp Phe His Ile Gln Gln 
    530                 535                 540                 


Val Glu Arg Arg Met Ser Arg Leu Lys Gly Glu Ile Asn Ser Glu Glu 
545                 550                 555                 560 


Lys Gln Ala Leu Glu Ala Lys Ile Val Glu Leu Arg Lys Ser Leu Glu 
                565                 570                 575     


Glu Lys Lys Ser Thr Cys Gly Leu Leu Glu Thr Gln Ile Lys Lys Leu 
            580                 585                 590         


His Asn Asp Leu Tyr Phe Ile Lys Lys Ala His Ser Lys Asn Ser Asp 
        595                 600                 605             


Glu Lys Gln Ser Leu Met Thr Lys Ile Asn Glu Leu Asn Leu Phe Ile 
    610                 615                 620                 


Asp Arg Ser Glu Lys Glu Leu Asp Lys Ala Lys Gly Phe Lys Gln Asp 
625                 630                 635                 640 


Leu Met Ile Glu Asp Asn Leu Leu Lys Leu Glu Val Lys Arg Thr Arg 
                645                 650                 655     


Glu Met Leu His Ser Lys Ala Glu Glu Val Leu Ser Leu Glu Lys Arg 
            660                 665                 670         


Lys Gln Gln Leu Tyr Thr Ala Met Glu Glu Arg Thr Glu Glu Ile Lys 
        675                 680                 685             


Val His Lys Thr Met Leu Ala Ser Gln Ile Arg Tyr Val Asp Gln Glu 
    690                 695                 700                 


Arg Glu Asn Ile Ser Thr Glu Phe Arg Glu Arg Leu Ser Lys Ile Glu 
705                 710                 715                 720 


Lys Leu Lys Asn Arg Tyr Glu Ile Leu Thr Val Val Met Leu Pro Pro 
                725                 730                 735     


Glu Gly Glu Glu Glu Lys Thr Gln Ala Tyr Tyr Val Ile Lys Val Met 
            740                 745                 750         


Ser Met Ser 
        755 


<210>  889
<211>  4239
<212>  DNA
<213>  Homosapiens

<400>  889
ctgtgggcct gggagctgcc tctgaggaac acgccgcagg gccaggcatg tgaggtctct     60

gcgggtcatg gagaacctcc ctgccgtgac cactgaggag ccgaccccca tggggagggg    120

tcctgtggga ccctcaggag gtggcagcac ccgggaccag gtccggactg tggtcatgag    180

gccctctgtg agctgggaga aagcggggcc cgaggaggcc aaggcgccgg tgagaggcga    240

cgaggctcct cctgcccgcg tggctgggcc tgctgctggg acccctccct gccagatggg    300

ggtttatccc acagacctga ccctgcagct gctggctgtg cggaggaaga gcagactgcg    360

ggaccccggc ctacagcaga ccctccgggg ccagctccgc ctgctggaga atgatagccg    420

ggagatggcc cgcgtgcttg gggaattatc agccaggctg ctgtccatcc acagtgacca    480

ggaccggatc gtggtgacgt ttaagacttt tgaagaaatc tggaagtttt ccacctacca    540

tgctctcggc ttcactcatc actgcctggc aaacctgctc atggaccagg ccttctggct    600

gctcttgccc agtgaggagg aggagacggc catccaagtc catgtggatg agaacgcctt    660

aaggctgacc cacgagagcc tcctcatcca agaagggccc ttctttgtcc tgtgtcctga    720

ccaccatgtg agagtgatga cgggtccccg ggatgcagga aatggccccc aggccctcag    780

gcaggcttcg ggggcacccc agggagaggc ggccccggaa acagactctt caccgccgag    840

ccccagcgtg tcctccgagg aggtggcagt ggcggccgcc ccggagcctt tgattccatt    900

tcatcagtgg gctcttagga tcccccagga ccccatcgac gatgccatgg gtggccctgt    960

gatgcccggc aacccgctga tggctgtggg cctggcctcg gcattggcag acttccaggg   1020

ctcggggccc gaagagatga ccttccgagg tggcgacctc atcgagatcc ttggggcgca   1080

ggtgcccagc ctgccctggt gcgtgggccg acacgcagcc tcgggccggg tggggtttgt   1140

gcggagcagc ctcatcagca tgcagggccc cgtgtccgag ttggaaagtg cgatttttct   1200

caatgaggaa gaaaagtcat tcttcagcga gggctgcttt tctgaggagg atgccaggca   1260

gttgctgagg cggatgtcgg gcaccgatgt ctgcagcgtg tacagcctgg actcagtaga   1320

ggaagctgag accgagcagc cgcaggaaaa agaaatacct ccaccttgcc tgagcccgga   1380

gccacaggag accttgcaga aggtgaagaa tgttctggaa caatgcaaga cctgcccagg   1440

ctgcccccag gagccagcgt cctggggtct ctgtgcggca tccagcgacg tgagcttgca   1500

ggaccccgag gagccctcct tctgcttgga agccgaggac gactgggagg acccagaggc   1560

cctgagctca ctgctgctgt tcctgaacgc ccctgggtac aaggccagct tccgtggcct   1620

gtacgatgtg gcgctgccgt ggctgagcag cgtgttccgc agcttcagcg acgaggagga   1680

gctgactggg cgcctggcac aggcccgggg ggcggccaag aaagctggcc tcctcatggc   1740

cctggccagg ctctgcttcc tcctggggcg gctgtgcagc aggaggctca agctgtccca   1800

ggcccgggtg tactttgagg aagcgctggg ggccctggag ggcagcttcg gggacctgtt   1860

cctggtggtg gctgtgtacg ccaacctggc cagcatttac cggaagcaga agaaccggga   1920

gaagtgtgca caggtggtgc ccaaagccat ggccctgctc ctggggacgc ccgaccacat   1980

ctgcagcacc gaggcggagg gggagctcct gcagctggcg ctgcggcggg cggtgggtgg   2040

ccagagcctg caggccgagg cccgggcctg cttcctgctg gccaggcacc acgtgcacct   2100

caagcagccc gaggaggccc tgcccttcct agagcggctg ctgcttttgc acagggactc   2160

gggagcccca gaggccgcgt ggctctcaga ctgctaccta ctcctggctg acatctacag   2220

ccgcaagtgc ctgccccacc tggtgctgag ctgtgtcaag gtggcctcat tgcggacacg   2280

gggctcgctg gccggctcgc tgaggagtgt gaacctggtg ctccagaacg ccccccagcc   2340

ccacagcctc cctgcccaaa cttcccacta cctcaggcaa gcgctggcct ccctgacccc   2400

gggcacaggc caggcgctgc gcggccccct ctacaccagc ttggcccagc tgtacagcca   2460

ccatggctgc cacggcccgg ccatcacctt catgacgcag gcagtggaag ccagtgctat   2520

tgccggagtc cgtgccatcg tggaccacct ggtggccctg gcctggctgc acgtgcttca   2580

tgggcagagc ccggtggccc tggacatcct gcagtctgtc cgggatgcag tggtggccag   2640

cgaggaccag gagggcgtga ttgccaacat ggtggccgtg gctctgaaga ggacgggccg   2700

gacgaggcag gcagctgaga gctactaccg cgccctgcgg gtggctcggg acctgggcca   2760

gcaaaggaac caggcagtgg ggctggccaa cttcggggcc ctgtgcctgc atgcgggtgc   2820

cagcaggctg gcccagcact acctcctgga ggccgtgcgg ctgttctcga ggctgcccct   2880

tggggagtgt ggccgggact tcacccacgt gctcctgcag ctgggccatc tctgcacccg   2940

ccagggcccg gcccagcagg gcaagggcta ctacgagtgg gcccttctgg tcgccgtgga   3000

gatgggccac gtggagagcc agctgcgggc cgtccagcgg ctgtgccact tctacagcgc   3060

cgtcatgccc agcgaggccc agtgtgtcat ctaccatgag ctccagctct ccccggcctg   3120

caaggtggcc gacaaggtgc tggaggggca gctcctggag accatcagcc agctctacct   3180

gtccctgggc accgagcggg cctacaaatc cgcactggac tacaccaaac gaagtctggg   3240

gattttcatt gacctccaga agaaagagaa ggaggcgcat gcctggctgc aagcagggaa   3300

gatctattac atcttgcggc agagcgagct ggtggacctc tacatccagg tggcacagaa   3360

cgtggccctg tacacaggcg accccaacct ggggctggag ctgtttgagg cggctggaga   3420

catcttcttc gacggggcct gggagcggga gaaagctgtg tccttctacc gggaccgggc   3480

cctgcccctg gcagtgacta cgggcaaccg caaggcggag ctgcggctgt gcaacaagct   3540

ggtggcactg ctggccacgc tggaggagcc ccaggagggc ttggagtttg cccacatggc   3600

cctagcactc agcatcaccc tgggggaccg gctgaacgag cgcgtggcct accaccggct   3660

ggccgccctg caacaccgac tgggccatgg cgagctggca gagcacttct acctcaaggc   3720

cctgtcgctc tgcaactcgc cgctggagtt tgacgaggag accctctact acgtgaaggt   3780

gtacctggtg ctcggtgaca tcatcttcta cgacctgaag gacccgtttg atgcagccgg   3840

gtactaccag ctggcgctgg cggccgccgt ggacctgggc aacaagaagg cacagctgaa   3900

gatctacacg cggctggcca ccatctacca caacttcctc ctggaccgtg agaagtcgct   3960

cttcttctac cagaaggcca ggaccttcgc cacagagctc aacgtccgca gggtcaacct   4020

gcctcctctg ccactctgcg ggtgggcccc ctggttggcc cccagccacc ctcgctgagg   4080

acagcatcca agggagtggg ttttgtgcaa gggctggggg tctcctgcct ctcctggtgt   4140

cgccggtggc tcattttctg gcaaatggag gcacgaacgc aggggccaaa tagcaataaa   4200

tgggttttgt tttttttttg caataaaaaa aaaaaaaaa                          4239


<210>  890
<211>  1336
<212>  PRT
<213>  Homosapiens

<400>  890

Met Glu Asn Leu Pro Ala Val Thr Thr Glu Glu Pro Thr Pro Met Gly 
1               5                   10                  15      


Arg Gly Pro Val Gly Pro Ser Gly Gly Gly Ser Thr Arg Asp Gln Val 
            20                  25                  30          


Arg Thr Val Val Met Arg Pro Ser Val Ser Trp Glu Lys Ala Gly Pro 
        35                  40                  45              


Glu Glu Ala Lys Ala Pro Val Arg Gly Asp Glu Ala Pro Pro Ala Arg 
    50                  55                  60                  


Val Ala Gly Pro Ala Ala Gly Thr Pro Pro Cys Gln Met Gly Val Tyr 
65                  70                  75                  80  


Pro Thr Asp Leu Thr Leu Gln Leu Leu Ala Val Arg Arg Lys Ser Arg 
                85                  90                  95      


Leu Arg Asp Pro Gly Leu Gln Gln Thr Leu Arg Gly Gln Leu Arg Leu 
            100                 105                 110         


Leu Glu Asn Asp Ser Arg Glu Met Ala Arg Val Leu Gly Glu Leu Ser 
        115                 120                 125             


Ala Arg Leu Leu Ser Ile His Ser Asp Gln Asp Arg Ile Val Val Thr 
    130                 135                 140                 


Phe Lys Thr Phe Glu Glu Ile Trp Lys Phe Ser Thr Tyr His Ala Leu 
145                 150                 155                 160 


Gly Phe Thr His His Cys Leu Ala Asn Leu Leu Met Asp Gln Ala Phe 
                165                 170                 175     


Trp Leu Leu Leu Pro Ser Glu Glu Glu Glu Thr Ala Ile Gln Val His 
            180                 185                 190         


Val Asp Glu Asn Ala Leu Arg Leu Thr His Glu Ser Leu Leu Ile Gln 
        195                 200                 205             


Glu Gly Pro Phe Phe Val Leu Cys Pro Asp His His Val Arg Val Met 
    210                 215                 220                 


Thr Gly Pro Arg Asp Ala Gly Asn Gly Pro Gln Ala Leu Arg Gln Ala 
225                 230                 235                 240 


Ser Gly Ala Pro Gln Gly Glu Ala Ala Pro Glu Thr Asp Ser Ser Pro 
                245                 250                 255     


Pro Ser Pro Ser Val Ser Ser Glu Glu Val Ala Val Ala Ala Ala Pro 
            260                 265                 270         


Glu Pro Leu Ile Pro Phe His Gln Trp Ala Leu Arg Ile Pro Gln Asp 
        275                 280                 285             


Pro Ile Asp Asp Ala Met Gly Gly Pro Val Met Pro Gly Asn Pro Leu 
    290                 295                 300                 


Met Ala Val Gly Leu Ala Ser Ala Leu Ala Asp Phe Gln Gly Ser Gly 
305                 310                 315                 320 


Pro Glu Glu Met Thr Phe Arg Gly Gly Asp Leu Ile Glu Ile Leu Gly 
                325                 330                 335     


Ala Gln Val Pro Ser Leu Pro Trp Cys Val Gly Arg His Ala Ala Ser 
            340                 345                 350         


Gly Arg Val Gly Phe Val Arg Ser Ser Leu Ile Ser Met Gln Gly Pro 
        355                 360                 365             


Val Ser Glu Leu Glu Ser Ala Ile Phe Leu Asn Glu Glu Glu Lys Ser 
    370                 375                 380                 


Phe Phe Ser Glu Gly Cys Phe Ser Glu Glu Asp Ala Arg Gln Leu Leu 
385                 390                 395                 400 


Arg Arg Met Ser Gly Thr Asp Val Cys Ser Val Tyr Ser Leu Asp Ser 
                405                 410                 415     


Val Glu Glu Ala Glu Thr Glu Gln Pro Gln Glu Lys Glu Ile Pro Pro 
            420                 425                 430         


Pro Cys Leu Ser Pro Glu Pro Gln Glu Thr Leu Gln Lys Val Lys Asn 
        435                 440                 445             


Val Leu Glu Gln Cys Lys Thr Cys Pro Gly Cys Pro Gln Glu Pro Ala 
    450                 455                 460                 


Ser Trp Gly Leu Cys Ala Ala Ser Ser Asp Val Ser Leu Gln Asp Pro 
465                 470                 475                 480 


Glu Glu Pro Ser Phe Cys Leu Glu Ala Glu Asp Asp Trp Glu Asp Pro 
                485                 490                 495     


Glu Ala Leu Ser Ser Leu Leu Leu Phe Leu Asn Ala Pro Gly Tyr Lys 
            500                 505                 510         


Ala Ser Phe Arg Gly Leu Tyr Asp Val Ala Leu Pro Trp Leu Ser Ser 
        515                 520                 525             


Val Phe Arg Ser Phe Ser Asp Glu Glu Glu Leu Thr Gly Arg Leu Ala 
    530                 535                 540                 


Gln Ala Arg Gly Ala Ala Lys Lys Ala Gly Leu Leu Met Ala Leu Ala 
545                 550                 555                 560 


Arg Leu Cys Phe Leu Leu Gly Arg Leu Cys Ser Arg Arg Leu Lys Leu 
                565                 570                 575     


Ser Gln Ala Arg Val Tyr Phe Glu Glu Ala Leu Gly Ala Leu Glu Gly 
            580                 585                 590         


Ser Phe Gly Asp Leu Phe Leu Val Val Ala Val Tyr Ala Asn Leu Ala 
        595                 600                 605             


Ser Ile Tyr Arg Lys Gln Lys Asn Arg Glu Lys Cys Ala Gln Val Val 
    610                 615                 620                 


Pro Lys Ala Met Ala Leu Leu Leu Gly Thr Pro Asp His Ile Cys Ser 
625                 630                 635                 640 


Thr Glu Ala Glu Gly Glu Leu Leu Gln Leu Ala Leu Arg Arg Ala Val 
                645                 650                 655     


Gly Gly Gln Ser Leu Gln Ala Glu Ala Arg Ala Cys Phe Leu Leu Ala 
            660                 665                 670         


Arg His His Val His Leu Lys Gln Pro Glu Glu Ala Leu Pro Phe Leu 
        675                 680                 685             


Glu Arg Leu Leu Leu Leu His Arg Asp Ser Gly Ala Pro Glu Ala Ala 
    690                 695                 700                 


Trp Leu Ser Asp Cys Tyr Leu Leu Leu Ala Asp Ile Tyr Ser Arg Lys 
705                 710                 715                 720 


Cys Leu Pro His Leu Val Leu Ser Cys Val Lys Val Ala Ser Leu Arg 
                725                 730                 735     


Thr Arg Gly Ser Leu Ala Gly Ser Leu Arg Ser Val Asn Leu Val Leu 
            740                 745                 750         


Gln Asn Ala Pro Gln Pro His Ser Leu Pro Ala Gln Thr Ser His Tyr 
        755                 760                 765             


Leu Arg Gln Ala Leu Ala Ser Leu Thr Pro Gly Thr Gly Gln Ala Leu 
    770                 775                 780                 


Arg Gly Pro Leu Tyr Thr Ser Leu Ala Gln Leu Tyr Ser His His Gly 
785                 790                 795                 800 


Cys His Gly Pro Ala Ile Thr Phe Met Thr Gln Ala Val Glu Ala Ser 
                805                 810                 815     


Ala Ile Ala Gly Val Arg Ala Ile Val Asp His Leu Val Ala Leu Ala 
            820                 825                 830         


Trp Leu His Val Leu His Gly Gln Ser Pro Val Ala Leu Asp Ile Leu 
        835                 840                 845             


Gln Ser Val Arg Asp Ala Val Val Ala Ser Glu Asp Gln Glu Gly Val 
    850                 855                 860                 


Ile Ala Asn Met Val Ala Val Ala Leu Lys Arg Thr Gly Arg Thr Arg 
865                 870                 875                 880 


Gln Ala Ala Glu Ser Tyr Tyr Arg Ala Leu Arg Val Ala Arg Asp Leu 
                885                 890                 895     


Gly Gln Gln Arg Asn Gln Ala Val Gly Leu Ala Asn Phe Gly Ala Leu 
            900                 905                 910         


Cys Leu His Ala Gly Ala Ser Arg Leu Ala Gln His Tyr Leu Leu Glu 
        915                 920                 925             


Ala Val Arg Leu Phe Ser Arg Leu Pro Leu Gly Glu Cys Gly Arg Asp 
    930                 935                 940                 


Phe Thr His Val Leu Leu Gln Leu Gly His Leu Cys Thr Arg Gln Gly 
945                 950                 955                 960 


Pro Ala Gln Gln Gly Lys Gly Tyr Tyr Glu Trp Ala Leu Leu Val Ala 
                965                 970                 975     


Val Glu Met Gly His Val Glu Ser Gln Leu Arg Ala Val Gln Arg Leu 
            980                 985                 990         


Cys His Phe Tyr Ser Ala Val Met  Pro Ser Glu Ala Gln  Cys Val Ile 
        995                 1000                 1005             


Tyr His  Glu Leu Gln Leu Ser  Pro Ala Cys Lys Val  Ala Asp Lys 
    1010                 1015                 1020             


Val Leu  Glu Gly Gln Leu Leu  Glu Thr Ile Ser Gln  Leu Tyr Leu 
    1025                 1030                 1035             


Ser Leu  Gly Thr Glu Arg Ala  Tyr Lys Ser Ala Leu  Asp Tyr Thr 
    1040                 1045                 1050             


Lys Arg  Ser Leu Gly Ile Phe  Ile Asp Leu Gln Lys  Lys Glu Lys 
    1055                 1060                 1065             


Glu Ala  His Ala Trp Leu Gln  Ala Gly Lys Ile Tyr  Tyr Ile Leu 
    1070                 1075                 1080             


Arg Gln  Ser Glu Leu Val Asp  Leu Tyr Ile Gln Val  Ala Gln Asn 
    1085                 1090                 1095             


Val Ala  Leu Tyr Thr Gly Asp  Pro Asn Leu Gly Leu  Glu Leu Phe 
    1100                 1105                 1110             


Glu Ala  Ala Gly Asp Ile Phe  Phe Asp Gly Ala Trp  Glu Arg Glu 
    1115                 1120                 1125             


Lys Ala  Val Ser Phe Tyr Arg  Asp Arg Ala Leu Pro  Leu Ala Val 
    1130                 1135                 1140             


Thr Thr  Gly Asn Arg Lys Ala  Glu Leu Arg Leu Cys  Asn Lys Leu 
    1145                 1150                 1155             


Val Ala  Leu Leu Ala Thr Leu  Glu Glu Pro Gln Glu  Gly Leu Glu 
    1160                 1165                 1170             


Phe Ala  His Met Ala Leu Ala  Leu Ser Ile Thr Leu  Gly Asp Arg 
    1175                 1180                 1185             


Leu Asn  Glu Arg Val Ala Tyr  His Arg Leu Ala Ala  Leu Gln His 
    1190                 1195                 1200             


Arg Leu  Gly His Gly Glu Leu  Ala Glu His Phe Tyr  Leu Lys Ala 
    1205                 1210                 1215             


Leu Ser  Leu Cys Asn Ser Pro  Leu Glu Phe Asp Glu  Glu Thr Leu 
    1220                 1225                 1230             


Tyr Tyr  Val Lys Val Tyr Leu  Val Leu Gly Asp Ile  Ile Phe Tyr 
    1235                 1240                 1245             


Asp Leu  Lys Asp Pro Phe Asp  Ala Ala Gly Tyr Tyr  Gln Leu Ala 
    1250                 1255                 1260             


Leu Ala  Ala Ala Val Asp Leu  Gly Asn Lys Lys Ala  Gln Leu Lys 
    1265                 1270                 1275             


Ile Tyr  Thr Arg Leu Ala Thr  Ile Tyr His Asn Phe  Leu Leu Asp 
    1280                 1285                 1290             


Arg Glu  Lys Ser Leu Phe Phe  Tyr Gln Lys Ala Arg  Thr Phe Ala 
    1295                 1300                 1305             


Thr Glu  Leu Asn Val Arg Arg  Val Asn Leu Pro Pro  Leu Pro Leu 
    1310                 1315                 1320             


Cys Gly  Trp Ala Pro Trp Leu  Ala Pro Ser His Pro  Arg 
    1325                 1330                 1335     


<210>  891
<211>  2585
<212>  DNA
<213>  Homosapiens

<400>  891
gggagctggt ccctgcgctc cctgcgccct ggggatgccc ctgccgccct gacgcccgcc     60

agcctgagcc accggcgcat gtgaccgcgc gtccgcccca gtcccatccg taggcgcccg    120

gcgcccggcc ccgcagcggc ctcgttgtcc ccgccggccc ccgcccggtc tcccgcgctg    180

ccacccgccg ccggccctgc cgccatgcag gcgcgagcgc tgctcctggc cgcgttggcc    240

gcgctggcgc tggcccggga gccccctgcg gcgccgtgtc ccgcgcgctg cgacgtgtcg    300

cggtgtccca gcccccgctg ccccggcggc tacgtgcccg acctctgcaa ctgctgcctg    360

gtgtgcgccg ccagcgaggg cgagccctgt ggcggccctc tggactcgcc ttgcggcgag    420

agcctggagt gcgtgcgcgg cctatgccgc tgccgctggt cgcacgccgt gtgtggcacc    480

gacgggcaca cctatgccaa cgtgtgcgcg ctgcaggcgg ccagccgccg cgcgctgcag    540

ctctccggga cgcccgtgcg ccagctgcag aagggcgcct gcccgttggg tctccaccag    600

ctgagcagcc cgcgctacaa gttcaacttc attgctgacg tggtggagaa gatcgcacca    660

gccgtggtcc acatagagct cttcctgaga cacccgctgt ttggccgcaa cgtgcccctg    720

tccagcggtt ctggcttcat catgtcagag gccggcctga tcatcaccaa tgcccacgtg    780

gtgtccagca acagtgctgc cccgggcagg cagcagctca aggtgcagct acagaatggg    840

gactcctatg aggccaccat caaagacatc gacaagaagt cggacattgc caccatcaag    900

atccatccca agaaaaagct ccctgtgttg ttgctgggtc actcggccga cctgcggcct    960

ggggagtttg tggtggccat cggcagtccc ttcgccctac agaacacagt gacaacgggc   1020

atcgtcagca ctgcccagcg ggagggcagg gagctgggcc tccgggactc cgacatggac   1080

tacatccaga cggatgccat catcaactac gggaactccg ggggaccact ggtgaacctg   1140

gatggcgagg tcattggcat caacacgctc aaggtcacgg ctggcatctc ctttgccatc   1200

ccctcagacc gcatcacacg gttcctcaca gagttccaag acaagcagat caaagactgg   1260

aagaagcgct tcatcggcat acggatgcgg acgatcacac caagcctggt ggatgagctg   1320

aaggccagca acccggactt cccagaggtc agcagtggaa tttatgtgca agaggttgcg   1380

ccgaattcac cttctcagag aggcggcatc caagatggtg acatcatcgt caaggtcaac   1440

gggcgtcctc tagtggactc gagtgagctg caggaggccg tgctgaccga gtctcctctc   1500

ctactggagg tgcggcgggg gaacgacgac ctcctcttca gcatcgcacc tgaggtggtc   1560

atgtgagggg cgcattcctc cagcgccaag cgtcagagcc tgcagacaac ggagggcagc   1620

gcccccccga gatcaggacg aaggaccacc gtcggtcctc agcagggcgg cagcctcctc   1680

ctggctgtcc ggggcagagc ggaggctggg cttggccagg ggcccgaatt tccgcctggg   1740

gagtgttgga tccacatccc ggtgccgggg agggaagccc aacatcccct tgtacagatg   1800

atcctgaaag tcacttccaa gttctccgga tattcacaaa actgccttcc atggaggtcc   1860

cctcctctcc tagcttcccg cctctgcccc tgtgaacacc catctgcagt atcccctgct   1920

cctgcccctc ctactgcagg tctgggctgc caagcttctt cccccctgac aaacgcccac   1980

ctgacctgag gccccagctt ccctctgccc taggacttac caagctgtag ggccagggct   2040

gctgcctgcc agcctggggt ccctggagga caggtcacat ctgatccctt tggggtgcgg   2100

gggtggggtc cagcccagag caggcactga gtgaatgccc cctggctgcg gagctgagcc   2160

ccgccctgcc atgaggtttt cctccccagg caggcaggag gccgcgggga gcacgtggaa   2220

agttggctgc tgcctgggga agtttttcct ccccaaggcg gccatggggc agcctgcaga   2280

ggacagtgga cgtggagctg cggggtgtga ggactgagcc ggcttcccct tcccacgcag   2340

ttttgggatg cagcagccgc tcgcatggaa gtgccgccca gaggcatgca ggctgctggg   2400

cccccccccc tcatccaggg aacgagtgtg tctcaagggg catttgtgag ctttgctgta   2460

aatggattcc cagtgttgct tgtactgtat gtttctctac tgtatggaaa ataaagttta   2520

caagcacacg gttttcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2580

aaaaa                                                               2585


<210>  892
<211>  453
<212>  PRT
<213>  Homosapiens

<400>  892

Met Gln Ala Arg Ala Leu Leu Leu Ala Ala Leu Ala Ala Leu Ala Leu 
1               5                   10                  15      


Ala Arg Glu Pro Pro Ala Ala Pro Cys Pro Ala Arg Cys Asp Val Ser 
            20                  25                  30          


Arg Cys Pro Ser Pro Arg Cys Pro Gly Gly Tyr Val Pro Asp Leu Cys 
        35                  40                  45              


Asn Cys Cys Leu Val Cys Ala Ala Ser Glu Gly Glu Pro Cys Gly Gly 
    50                  55                  60                  


Pro Leu Asp Ser Pro Cys Gly Glu Ser Leu Glu Cys Val Arg Gly Leu 
65                  70                  75                  80  


Cys Arg Cys Arg Trp Ser His Ala Val Cys Gly Thr Asp Gly His Thr 
                85                  90                  95      


Tyr Ala Asn Val Cys Ala Leu Gln Ala Ala Ser Arg Arg Ala Leu Gln 
            100                 105                 110         


Leu Ser Gly Thr Pro Val Arg Gln Leu Gln Lys Gly Ala Cys Pro Leu 
        115                 120                 125             


Gly Leu His Gln Leu Ser Ser Pro Arg Tyr Lys Phe Asn Phe Ile Ala 
    130                 135                 140                 


Asp Val Val Glu Lys Ile Ala Pro Ala Val Val His Ile Glu Leu Phe 
145                 150                 155                 160 


Leu Arg His Pro Leu Phe Gly Arg Asn Val Pro Leu Ser Ser Gly Ser 
                165                 170                 175     


Gly Phe Ile Met Ser Glu Ala Gly Leu Ile Ile Thr Asn Ala His Val 
            180                 185                 190         


Val Ser Ser Asn Ser Ala Ala Pro Gly Arg Gln Gln Leu Lys Val Gln 
        195                 200                 205             


Leu Gln Asn Gly Asp Ser Tyr Glu Ala Thr Ile Lys Asp Ile Asp Lys 
    210                 215                 220                 


Lys Ser Asp Ile Ala Thr Ile Lys Ile His Pro Lys Lys Lys Leu Pro 
225                 230                 235                 240 


Val Leu Leu Leu Gly His Ser Ala Asp Leu Arg Pro Gly Glu Phe Val 
                245                 250                 255     


Val Ala Ile Gly Ser Pro Phe Ala Leu Gln Asn Thr Val Thr Thr Gly 
            260                 265                 270         


Ile Val Ser Thr Ala Gln Arg Glu Gly Arg Glu Leu Gly Leu Arg Asp 
        275                 280                 285             


Ser Asp Met Asp Tyr Ile Gln Thr Asp Ala Ile Ile Asn Tyr Gly Asn 
    290                 295                 300                 


Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Ile Asn 
305                 310                 315                 320 


Thr Leu Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp Arg 
                325                 330                 335     


Ile Thr Arg Phe Leu Thr Glu Phe Gln Asp Lys Gln Ile Lys Asp Trp 
            340                 345                 350         


Lys Lys Arg Phe Ile Gly Ile Arg Met Arg Thr Ile Thr Pro Ser Leu 
        355                 360                 365             


Val Asp Glu Leu Lys Ala Ser Asn Pro Asp Phe Pro Glu Val Ser Ser 
    370                 375                 380                 


Gly Ile Tyr Val Gln Glu Val Ala Pro Asn Ser Pro Ser Gln Arg Gly 
385                 390                 395                 400 


Gly Ile Gln Asp Gly Asp Ile Ile Val Lys Val Asn Gly Arg Pro Leu 
                405                 410                 415     


Val Asp Ser Ser Glu Leu Gln Glu Ala Val Leu Thr Glu Ser Pro Leu 
            420                 425                 430         


Leu Leu Glu Val Arg Arg Gly Asn Asp Asp Leu Leu Phe Ser Ile Ala 
        435                 440                 445             


Pro Glu Val Val Met 
    450             


<210>  893
<211>  2415
<212>  DNA
<213>  Homosapiens

<400>  893
cggatccttt cctgcttttg gtttccctgg caggggttga actgtggagt gtgtgggctc     60

ttatcacgcg atggcatcca ctgtggaagg aggcgacaca gctctgctcc cagaattccc    120

cagggggccc ctcgatgcct accgagcaag agcgtccttc agctggaagg acgtggcgct    180

gttcacggaa ggggagggca atgtccgctt taagaaaacc atcttctcag ctcttgagaa    240

tgaccctctt ttcgctcgtt cccctggagc cgacctgtcc ttggagaagt atcgcgagct    300

gaacttcctt cgatgcaagc ggatcttcga gtatgacttc ctcagtgtcg aagcaatgtt    360

caagagccct ctgaaggtcc ccgccttgat tcagtgcctg ggcatgtatg actcttctct    420

ggctgccaag tacctcctcc atagcttggt ttttggatca gcagtttaca gttctggttc    480

tgaaagacat ctcacatata ttcaaaagat cttcaggatg gagatttttg gatgttttgc    540

tctgaccgaa ttaagccacg gcagtaatac caaggccatt cgcacaactg cccactacga    600

tcctgccact gaggaattca tcatacattc ccctgatttc gaagctgcca agttttgggt    660

tggcaacatg ggcaagacag ccactcacgc ggtggtgttt gctaagctgt gtgtgccagg    720

ggaccagtgc catgggctgc atccctttat cgtgcagatc cgggacccga agacccttct    780

tcccatgcct ggagtgatgg ttggcgacat aggaaaaaaa ctcgggcaga acggtctaga    840

taatggtttc gccatgttcc acaaggtcag agttcctcgc cagagccttc tgaaccggat    900

gggagacgtc acccccgagg gcacctatgt cagccccttt aaggacgtca ggcagcgctt    960

tggagcgtcc ctggggagcc tgtcctcggg ccgggtctcc atcgtgagcc tggccatcct   1020

taacctaaag ctggccgtgg ccatcgctct tcgcttctca gccactcggc gtcagtttgg   1080

acccacagag gaggaggaaa taccagtgct tgagtatcca atgcagcaat ggcgcttgct   1140

tccatatctg gcagctgtct acggcttaga ccatttctcc aagtcgctct tcctggacct   1200

ggtggagctc cagcgaggac ttgcatcggg agaccgcagc gccagacagg cagagcttgg   1260

acgtgagatc cacgccctgg catcggccag caagcccctg gcctcgtgga ccacccagca   1320

aggaattcag gaatgccggg aggcgtgtgg aggacacggc tatctggcca tgaaccggtt   1380

gggtgtcctt agagatgaca acgatcccaa ctgcacatac gaaggtgaca acaacatcct   1440

gctgcagcag acaagcaact atttgctggg tctcctggca caccaggtcc acgatggagc   1500

ttgcttccgc agtccgctga agtcagtgga ctttctggac gcctatcccg gcatccttga   1560

ccagaagttt gaggtctcca gtgttgccga ctgcttggac tctgcagtcg ccctggcagc   1620

atacaagtgg ctggtttgct acctgctccg agagacttat caaaaattaa accaagagaa   1680

aagatcagga agcagtgact ttgaagcaag gaacaaatgc caggtgtccc acggccgtcc   1740

gttggcgctg gccttcgtgg agctcacggt ggtccagagg ttccacgagc acgtgcacca   1800

gccttccgtg ccgccctcgc tgcgggccgt gctggggcgg ctcagtgctc tgtacgccct   1860

gtggtccctg aagcgccacg cggccctgct ctaccgagga ggatacttct ccggtgagca   1920

ggcgggagaa gtgttggaga gcgccgtcct ggctttgtgt tcccagctga aagacgatgc   1980

agttgccctg gtagacgtga tcgctcctcc tgactttgtt ctggactcac cgattggcag   2040

agccgacggc gagctctaca aaaacctctg gggcgctgtc ctgcaggaaa gcaaggtgtt   2100

ggagcgggca tcctggtggc cagagttttc tgtgaacaaa cctgtcatag gaagtctgaa   2160

atcgaagctc tagtgggact ggcacattca gccaagtcta atgaaacgaa gggaactaat   2220

cagacgtgga cctcaacttc tgattccaga acacgccgga gattgctgct gctttctgag   2280

cccgcacctg tgcgcctaaa ctgctgattg gcctcaactt gcccaggcgg acgggaggga   2340

ggcacccggc cggctggacc taatctggga tcgcggtgat ttgcaccgtg gaaaagaaat   2400

tgcagattga tcatg                                                    2415


<210>  894
<211>  700
<212>  PRT
<213>  Homosapiens

<400>  894

Met Ala Ser Thr Val Glu Gly Gly Asp Thr Ala Leu Leu Pro Glu Phe 
1               5                   10                  15      


Pro Arg Gly Pro Leu Asp Ala Tyr Arg Ala Arg Ala Ser Phe Ser Trp 
            20                  25                  30          


Lys Asp Val Ala Leu Phe Thr Glu Gly Glu Gly Asn Val Arg Phe Lys 
        35                  40                  45              


Lys Thr Ile Phe Ser Ala Leu Glu Asn Asp Pro Leu Phe Ala Arg Ser 
    50                  55                  60                  


Pro Gly Ala Asp Leu Ser Leu Glu Lys Tyr Arg Glu Leu Asn Phe Leu 
65                  70                  75                  80  


Arg Cys Lys Arg Ile Phe Glu Tyr Asp Phe Leu Ser Val Glu Ala Met 
                85                  90                  95      


Phe Lys Ser Pro Leu Lys Val Pro Ala Leu Ile Gln Cys Leu Gly Met 
            100                 105                 110         


Tyr Asp Ser Ser Leu Ala Ala Lys Tyr Leu Leu His Ser Leu Val Phe 
        115                 120                 125             


Gly Ser Ala Val Tyr Ser Ser Gly Ser Glu Arg His Leu Thr Tyr Ile 
    130                 135                 140                 


Gln Lys Ile Phe Arg Met Glu Ile Phe Gly Cys Phe Ala Leu Thr Glu 
145                 150                 155                 160 


Leu Ser His Gly Ser Asn Thr Lys Ala Ile Arg Thr Thr Ala His Tyr 
                165                 170                 175     


Asp Pro Ala Thr Glu Glu Phe Ile Ile His Ser Pro Asp Phe Glu Ala 
            180                 185                 190         


Ala Lys Phe Trp Val Gly Asn Met Gly Lys Thr Ala Thr His Ala Val 
        195                 200                 205             


Val Phe Ala Lys Leu Cys Val Pro Gly Asp Gln Cys His Gly Leu His 
    210                 215                 220                 


Pro Phe Ile Val Gln Ile Arg Asp Pro Lys Thr Leu Leu Pro Met Pro 
225                 230                 235                 240 


Gly Val Met Val Gly Asp Ile Gly Lys Lys Leu Gly Gln Asn Gly Leu 
                245                 250                 255     


Asp Asn Gly Phe Ala Met Phe His Lys Val Arg Val Pro Arg Gln Ser 
            260                 265                 270         


Leu Leu Asn Arg Met Gly Asp Val Thr Pro Glu Gly Thr Tyr Val Ser 
        275                 280                 285             


Pro Phe Lys Asp Val Arg Gln Arg Phe Gly Ala Ser Leu Gly Ser Leu 
    290                 295                 300                 


Ser Ser Gly Arg Val Ser Ile Val Ser Leu Ala Ile Leu Asn Leu Lys 
305                 310                 315                 320 


Leu Ala Val Ala Ile Ala Leu Arg Phe Ser Ala Thr Arg Arg Gln Phe 
                325                 330                 335     


Gly Pro Thr Glu Glu Glu Glu Ile Pro Val Leu Glu Tyr Pro Met Gln 
            340                 345                 350         


Gln Trp Arg Leu Leu Pro Tyr Leu Ala Ala Val Tyr Gly Leu Asp His 
        355                 360                 365             


Phe Ser Lys Ser Leu Phe Leu Asp Leu Val Glu Leu Gln Arg Gly Leu 
    370                 375                 380                 


Ala Ser Gly Asp Arg Ser Ala Arg Gln Ala Glu Leu Gly Arg Glu Ile 
385                 390                 395                 400 


His Ala Leu Ala Ser Ala Ser Lys Pro Leu Ala Ser Trp Thr Thr Gln 
                405                 410                 415     


Gln Gly Ile Gln Glu Cys Arg Glu Ala Cys Gly Gly His Gly Tyr Leu 
            420                 425                 430         


Ala Met Asn Arg Leu Gly Val Leu Arg Asp Asp Asn Asp Pro Asn Cys 
        435                 440                 445             


Thr Tyr Glu Gly Asp Asn Asn Ile Leu Leu Gln Gln Thr Ser Asn Tyr 
    450                 455                 460                 


Leu Leu Gly Leu Leu Ala His Gln Val His Asp Gly Ala Cys Phe Arg 
465                 470                 475                 480 


Ser Pro Leu Lys Ser Val Asp Phe Leu Asp Ala Tyr Pro Gly Ile Leu 
                485                 490                 495     


Asp Gln Lys Phe Glu Val Ser Ser Val Ala Asp Cys Leu Asp Ser Ala 
            500                 505                 510         


Val Ala Leu Ala Ala Tyr Lys Trp Leu Val Cys Tyr Leu Leu Arg Glu 
        515                 520                 525             


Thr Tyr Gln Lys Leu Asn Gln Glu Lys Arg Ser Gly Ser Ser Asp Phe 
    530                 535                 540                 


Glu Ala Arg Asn Lys Cys Gln Val Ser His Gly Arg Pro Leu Ala Leu 
545                 550                 555                 560 


Ala Phe Val Glu Leu Thr Val Val Gln Arg Phe His Glu His Val His 
                565                 570                 575     


Gln Pro Ser Val Pro Pro Ser Leu Arg Ala Val Leu Gly Arg Leu Ser 
            580                 585                 590         


Ala Leu Tyr Ala Leu Trp Ser Leu Lys Arg His Ala Ala Leu Leu Tyr 
        595                 600                 605             


Arg Gly Gly Tyr Phe Ser Gly Glu Gln Ala Gly Glu Val Leu Glu Ser 
    610                 615                 620                 


Ala Val Leu Ala Leu Cys Ser Gln Leu Lys Asp Asp Ala Val Ala Leu 
625                 630                 635                 640 


Val Asp Val Ile Ala Pro Pro Asp Phe Val Leu Asp Ser Pro Ile Gly 
                645                 650                 655     


Arg Ala Asp Gly Glu Leu Tyr Lys Asn Leu Trp Gly Ala Val Leu Gln 
            660                 665                 670         


Glu Ser Lys Val Leu Glu Arg Ala Ser Trp Trp Pro Glu Phe Ser Val 
        675                 680                 685             


Asn Lys Pro Val Ile Gly Ser Leu Lys Ser Lys Leu 
    690                 695                 700 


<210>  895
<211>  1851
<212>  DNA
<213>  Homosapiens

<400>  895
aagctcttag aggcgtaggc aaatatgtgc aggccatcag tacagtactg tgcagtacag     60

cagcaagaaa atcagcttgg taccaccaga ctgggctgca ggttccagct gttgctgcta    120

gcaggaagtg gctaagctgg ccatcgtatc acaggcatcc aggcagaggg attgatgtcc    180

gaagaagaaa aatctgggac atgtatggac cacaaactca gttagaggaa gatgcaatca    240

cacccaatga taagaccctt ttccctgatg ttgattggtt aatcggtaac cattctgatg    300

aactcacacc atggatacct gtcattgcag ccaggtcttc ctacaattgc cgcttctttg    360

tcctcccctg ctgcttcttt gacttcattg gaagatactc ccggaggcag agtaagaaga    420

ctcagtaccg ggaatacctt gacttcatta aagaagtggg cttcacctgt gggtttcacg    480

tggacgaaga ctgcctcagg attccttcaa ccaaaagagt ctgtctcgtt ggaaaatcca    540

gaacataccc ttcctccaga gaagcttccg tggatgaaaa gaggactcag tacattaaga    600

gcaggcgggg ctgccctgta agcccacctg gctgggagct ttccccttct ccacgctggg    660

ttgctgctgg cagtgctggt cactgtgacg gtcagcaagc tctggacgcc agggtcgggt    720

gtgtaaccag ggcctgggcc gctgagcatg gagcagggcc ccaggctgaa ggaccctggc    780

tacctggatt tcatcccaga gaaaaggctg agcgtgtgag gaactgtgcc gccctgccac    840

gagattttat tgaccaagtg gttttgcaag tagcgaattt actgttaggt ggaaagcaat    900

taaacacaag aagttctcga aatgggagtt tgaagacctg gaatggggga gagagcctat    960

ctctggcaga agtagccaac gagctggaca cggagaccct gcggaggctg aagcgggagt   1020

gtgggggcct gcagacgctg ctccggaaca gccaccaggt gttccaagtt gtgaatggga   1080

gagttcacat ccgcgactgg cgagaggaga cactgtggaa gacaaagcaa ccggaagcga   1140

aacagagact gctctctgaa gcctgcaaaa cccgcctctg ctggttcttc atgcatcacc   1200

ctgatggctg cgctctgtcc acggactgct gcccgtttgc ccatgggcct gcggagctgc   1260

ggccaccccg gaccaccccg aggaagaaga tttcatgagc tgcatccttg ccagccgagg   1320

cctggttggg gaggccaaac caaggagagc ttccccagca gtcgtcagtg ctgtggtctc   1380

tgctctggct gtgtttcagc ccacctcctc ccagctttct ccacatcctc acagtgatga   1440

accgtatttc ataaacatca cacgccagag aagccacagt tactcggaag cccccagctg   1500

actgcctggc ttgtttcaga tgcagccgct tgaaacgtgc gcagcatctt catatcataa   1560

agattgtgca cggatcctta caatgtctcc tgggggagag cggctgaggc tgccttgcac   1620

aggcccttcc cagggcgctg tccgacgcct gccccaccat gtccacatct gtgaagagga   1680

tggggctcct cgagaagtaa gaccgtatct gccagcgttt ctcaccacac tggagagcag   1740

ctgctctgga gcagggatcc accagattgg tatttttaaa aaaggtgtca ggcttgctat   1800

gttgaggttg tttttagagt tacagagaat aaaaacactc ataatttcct g            1851


<210>  896
<211>  365
<212>  PRT
<213>  Homosapiens

<400>  896

Met Tyr Gly Pro Gln Thr Gln Leu Glu Glu Asp Ala Ile Thr Pro Asn 
1               5                   10                  15      


Asp Lys Thr Leu Phe Pro Asp Val Asp Trp Leu Ile Gly Asn His Ser 
            20                  25                  30          


Asp Glu Leu Thr Pro Trp Ile Pro Val Ile Ala Ala Arg Ser Ser Tyr 
        35                  40                  45              


Asn Cys Arg Phe Phe Val Leu Pro Cys Cys Phe Phe Asp Phe Ile Gly 
    50                  55                  60                  


Arg Tyr Ser Arg Arg Gln Ser Lys Lys Thr Gln Tyr Arg Glu Tyr Leu 
65                  70                  75                  80  


Asp Phe Ile Lys Glu Val Gly Phe Thr Cys Gly Phe His Val Asp Glu 
                85                  90                  95      


Asp Cys Leu Arg Ile Pro Ser Thr Lys Arg Val Cys Leu Val Gly Lys 
            100                 105                 110         


Ser Arg Thr Tyr Pro Ser Ser Arg Glu Ala Ser Val Asp Glu Lys Arg 
        115                 120                 125             


Thr Gln Tyr Ile Lys Ser Arg Arg Gly Cys Pro Val Ser Pro Pro Gly 
    130                 135                 140                 


Trp Glu Leu Ser Pro Ser Pro Arg Trp Val Ala Ala Gly Ser Ala Gly 
145                 150                 155                 160 


His Cys Asp Gly Gln Gln Ala Leu Asp Ala Arg Val Gly Cys Val Thr 
                165                 170                 175     


Arg Ala Trp Ala Ala Glu His Gly Ala Gly Pro Gln Ala Glu Gly Pro 
            180                 185                 190         


Trp Leu Pro Gly Phe His Pro Arg Glu Lys Ala Glu Arg Val Arg Asn 
        195                 200                 205             


Cys Ala Ala Leu Pro Arg Asp Phe Ile Asp Gln Val Val Leu Gln Val 
    210                 215                 220                 


Ala Asn Leu Leu Leu Gly Gly Lys Gln Leu Asn Thr Arg Ser Ser Arg 
225                 230                 235                 240 


Asn Gly Ser Leu Lys Thr Trp Asn Gly Gly Glu Ser Leu Ser Leu Ala 
                245                 250                 255     


Glu Val Ala Asn Glu Leu Asp Thr Glu Thr Leu Arg Arg Leu Lys Arg 
            260                 265                 270         


Glu Cys Gly Gly Leu Gln Thr Leu Leu Arg Asn Ser His Gln Val Phe 
        275                 280                 285             


Gln Val Val Asn Gly Arg Val His Ile Arg Asp Trp Arg Glu Glu Thr 
    290                 295                 300                 


Leu Trp Lys Thr Lys Gln Pro Glu Ala Lys Gln Arg Leu Leu Ser Glu 
305                 310                 315                 320 


Ala Cys Lys Thr Arg Leu Cys Trp Phe Phe Met His His Pro Asp Gly 
                325                 330                 335     


Cys Ala Leu Ser Thr Asp Cys Cys Pro Phe Ala His Gly Pro Ala Glu 
            340                 345                 350         


Leu Arg Pro Pro Arg Thr Thr Pro Arg Lys Lys Ile Ser 
        355                 360                 365 


<210>  897
<211>  1550
<212>  DNA
<213>  Homosapiens

<400>  897
gtggcctacc atggtttcaa cgggtaacgg ggaataaggg ttcgattcgg agctgcggga     60

gccgggctgg caggagcagg atggcggcgg cggcggctgc aggcgaggcg cgccgggtgc    120

tggtgtacgg cggcaggggc gctctgggtt ctcgatgcgt gcaggctttt cgggcccgca    180

actggtgggt tgccagcgtt gatgtggtgg agaatgaaga ggccagcgct acgatcattg    240

ttaaaatgac agactcgttc actgagcagg ctgaccaggt gactgctgag gttggaaagc    300

tcttgggtga agagaaggtg gatgcaattc tttgcgttgc tggaggatgg gccgggggca    360

atgccaaatc caagtctctc tttaagaact gtgacctgat gtggaagcag agcatatgga    420

catcgaccat ctccagccat ctggctacca agcatctcaa ggaaggaggc ctcctgacct    480

tggctggcgc aaaggctgcc ctggatggga ctcctggtat gatcgggtac ggcatggcca    540

agggtgctgt tcaccagctc tgccagagcc tggctgggaa gaacagcggc atgccgcccg    600

gggcagccgc catcgctgtg ctcccggtta ccctggatac cccgatgaac aggaaatcaa    660

tgcctgaggc tgacttcagc tcctggacac ccttagaatt cctagttgaa actttccatg    720

actggatcac agggaaaaac cgaccgagct caggaagcct aatccaggtg gtaaccacag    780

aaggaaggac ggaactcacc ccagcatatt tttaggcctc atctcagtgc ctatgagggg    840

cctgccagaa aagtcactaa cctgtctcag tgtggccttg tccagccttg tgttttctgt    900

aacccctgtt tgtggtacga gataatgagt cctatttttc tctcacataa tatgcatttg    960

ctctcctagg gacaagtgta atacatttat gtgaagtaag acaatgcgag actggtggcc   1020

gtcaaatagc atccgtcaat ctgtgttaac tgcataggag gctctcgata gcacctgcta   1080

tagcggtgtc atgttggatc gctttgtgac tgttcatctg tccttgacag tggctgtcat   1140

cttgactact ttgttgattt gttggtattg gggacatttt aaaggctgag ttatttttga   1200

atgtcatgtt tatgtcatag acgtagaaaa cgcatccttg aattaaactg ccttaactcc   1260

ttttgtggta taagcaaact acatggactc tgtccctggt atccttttcc tgtgtggttg   1320

cccctgtgcc tgtggtctgg cctaggttaa gtgtgcaaga taactactcg tgagttattc   1380

agaatgttgt tcctaataaa tgcacttgtt gtctgtcttc tttaatcaaa tcacatctta   1440

tatacagcag tcagagatga gtatactaga atcatggatt gctggaggtc ttttaatctg   1500

atgttctcag aagggggtgg atttaaatcc tgaaataaat atttcaacac              1550


<210>  898
<211>  244
<212>  PRT
<213>  Homosapiens

<400>  898

Met Ala Ala Ala Ala Ala Ala Gly Glu Ala Arg Arg Val Leu Val Tyr 
1               5                   10                  15      


Gly Gly Arg Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala 
            20                  25                  30          


Arg Asn Trp Trp Val Ala Ser Val Asp Val Val Glu Asn Glu Glu Ala 
        35                  40                  45              


Ser Ala Thr Ile Ile Val Lys Met Thr Asp Ser Phe Thr Glu Gln Ala 
    50                  55                  60                  


Asp Gln Val Thr Ala Glu Val Gly Lys Leu Leu Gly Glu Glu Lys Val 
65                  70                  75                  80  


Asp Ala Ile Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala Lys 
                85                  90                  95      


Ser Lys Ser Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser Ile 
            100                 105                 110         


Trp Thr Ser Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys Glu 
        115                 120                 125             


Gly Gly Leu Leu Thr Leu Ala Gly Ala Lys Ala Ala Leu Asp Gly Thr 
    130                 135                 140                 


Pro Gly Met Ile Gly Tyr Gly Met Ala Lys Gly Ala Val His Gln Leu 
145                 150                 155                 160 


Cys Gln Ser Leu Ala Gly Lys Asn Ser Gly Met Pro Pro Gly Ala Ala 
                165                 170                 175     


Ala Ile Ala Val Leu Pro Val Thr Leu Asp Thr Pro Met Asn Arg Lys 
            180                 185                 190         


Ser Met Pro Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe Leu 
        195                 200                 205             


Val Glu Thr Phe His Asp Trp Ile Thr Gly Lys Asn Arg Pro Ser Ser 
    210                 215                 220                 


Gly Ser Leu Ile Gln Val Val Thr Thr Glu Gly Arg Thr Glu Leu Thr 
225                 230                 235                 240 


Pro Ala Tyr Phe 
                


<210>  899
<211>  499
<212>  DNA
<213>  Homosapiens

<400>  899
gtgatcatct tttctttgac attggaagca gaatctgaaa ctttctgagg agagcatttg     60

agcttcagat ttctaacagc ctctttgcaa caaaatagac cagtagctga aggcaactgc    120

aatccttcat gatgtttccc ttggccagaa atgcactaag cagtctcaag attcaaagca    180

ttctgcaaag catggcaaga catagccatg taaaacactc accagatttt catgataaat    240

atggtaatgc tgtgctagcc agtggaactg ctttctgtgt tgctacatgg gtgtttacag    300

ccactcagat tggaatagaa tggaacctat cccctgttgg cagagttacc ccaaaagagt    360

ggaaacatca gtaaccatca cagttgctgt aatgacagaa ttgtttaaaa aaccaacttg    420

tcatgtaagc actctactgc ttattaaaat atagcacaat tgaaaaaata aaatgtgttt    480

taaatcttta aaaaaaaaa                                                 499


<210>  900
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  900

Met Phe Pro Leu Ala Arg Asn Ala Leu Ser Ser Leu Lys Ile Gln Ser 
1               5                   10                  15      


Ile Leu Gln Ser Met Ala Arg His Ser His Val Lys His Ser Pro Asp 
            20                  25                  30          


Phe His Asp Lys Tyr Gly Asn Ala Val Leu Ala Ser Gly Thr Ala Phe 
        35                  40                  45              


Cys Val Ala Thr Trp Val Phe Thr Ala Thr Gln Ile Gly Ile Glu Trp 
    50                  55                  60                  


Asn Leu Ser Pro Val Gly Arg Val Thr Pro Lys Glu Trp Lys His Gln 
65                  70                  75                  80  


<210>  901
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  901
gggctggctg agcgcgggcg agtgtgagcg cgagtgtgcg cacgccgcgg gagcctctct     60

gccctctcct cgcaccctgc tcagggcatc tgaagagcct ggaaacgtga acaggcttga    120

agtatggcat gttgcaaaga tggtttctgc caagaaggta cccgcgatcg ctctgtccgc    180

cggggtcagt ttcgccctcc tgcgcttcct gtgcctggcg gtttgtttaa acgaatcccc    240

aggacagaac caaaaggagg agaaattgtg cacagaaaat ttcacccgca tcctggacag    300

tttgctcgat ggttatgaca acaggctgcg tcctggattt gggggtcctg ttacagaagt    360

gaaaactgac atatatgtca ccagctttgg acctgtttct gatgttgaaa tggaatacac    420

aatggatgtg ttcttcaggc agacatggat tgacaaaaga ttaaaatatg acggccccat    480

tgaaattttg agattgaaca atatgatggt aacgaaagtg tggacccctg atactttctt    540

caggaatgga aagaaatctg tctcacataa tatgacagct ccaaataagc tttttagaat    600

tatgagaaat ggtactattt tatacacaat gagactcacc ataagtgcgg agtgtcccat    660

gagattggtg gattttccca tggatggtca tgcatgccct ttgaaattcg ggagttatgc    720

ctatccaaag agtgagatga tctatacctg gacaaaaggt cctgagaaat cagttgaagt    780

tccgaaggag tcttccagct tagttcaata tgatttgatt gggcaaaccg tatcaagtga    840

aaccatcaaa tcaattacgg gtgaatatat tgttatgacg gtttacttcc acctcagacg    900

gaagatgggt tattttatga ttcagaccta tattccgtgc attatgacag tgattctttc    960

tcaagtttca ttttggataa ataaagaatc agttcccgct aggactgtat ttggaataac   1020

aactgtcctc accatgacca cactaagcat cagtgcacga cattctttgc ccaaagtgtc   1080

ctatgctacc gccatggact ggttcatagc tgtctgcttt gcttttgtat tttcggccct   1140

tatcgagttt gctgctgtca actatttcac caatattcaa atggaaaaag ccaaaaggaa   1200

gacatcaaag ccccctcagg aagttcccgc tgctccagtg cagagagaga agcatcctga   1260

agcccctctg cagaatacaa atgccaattt gaacatgaga aaaagaacaa atgctttggt   1320

tcactctgaa tctgatgttg gcaacagaac tgaggtggga aaccattcaa gcaaatcttc   1380

cacagttgtt caagaatctt ctaaaggcac acctcggtct tacttagctt ccagtccaaa   1440

cccattcagc cgtgcaaatg cagctgaaac catatctgca gcaagagcac ttccatctgc   1500

ttctcctact tctatccgaa ctggatatat gcctcgaaag gcttcagttg gatctgcttc   1560

tactcgtcac gtgtttggat caagactgca gaggataaag accacagtta ataccatagg   1620

ggctactggg aagttgtcag ctactcctcc tccatcggct ccaccacctt ctggatctgg   1680

cacaagtaaa atagacaaat atgcccgtat tctctttcca gtcacatttg gggcatttaa   1740

catggtttat tgggttgttt atttatctaa ggacactatg gagaaatcag aaagtctaat   1800

gtaatttcgt tgctatagta gtttgctaaa agatgatgaa aatgcagaat gtctttttaa   1860

atgtttttaa atataaacaa atattcttta ctaaaataaa aactctgtgt aatttttcca   1920

tttaaagata taagccagtt attgggagag ttaattaatt cctgagtgaa aaagtgaact   1980

atgttttttt tcagaaaaat tattttaaaa gaactcagca ttcagttaga tagaatacac   2040

accatcctgg aaagttggga taagagaaat agagctatta gagacaagtg gcgcatattt   2100

tttcattgat atttgaaaac agactatgac attttaaaaa tctgccctat gagtatcaac   2160

ctgccaccct aaatttccca gtggcactac ccttaaccag aattgtttat tagatgtcat   2220

atgcagtgac ctttggtgat cttcttagga acttcaagaa aaggaatttt cctgttaaat   2280

taaacattgg caaaaggaaa tggaatagta taaacactga tcaatagagt aaaatatctg   2340

ctgcataaaa aactaagaca aagaccagag gaaatatctt ccctttctta tgttggctaa   2400

acagtactta acagttgact tgaaattttg ttctctgagc caaagtttaa ctcattgtat   2460

gaattctttt tcatggtagt tcattcagtt atgtgtttat ttactacata gttattcaga   2520

gcctactgtg ttccaggaac tatgctagaa actgtctctc taggaaagct cttgcacctt   2580

tatctacaat attacttaaa aagtagaaca gtcaatgcat gccaaagaac cataaactag   2640

cagaggacat tgcattcttt agtgaaggac atttatttag agtctgacaa catattcaaa   2700

atatttttca gcctctactg atagtggata acaaatatat ttgttcacat aaccactttg   2760

atgtcagtac aacttcagca attggttttc aaaatagatg agaatatggt acagattgtt   2820

ctataagtga aaagcattat gtacttgaaa gtaaaaatca gggcaatata agacttaata   2880

gattaactgt cgcaaatttg atcagagtca cagagtagaa tttgatcaga atcacagaat   2940

catcagacat aggaactgag cacaggcttt ttcaggtgct ttccccaaga tagatctaga   3000

tattagctag tgaaatgcta aattttgaag agttttgtgt ccgtagttct gtaattctgg   3060

gcagtcatca tgttggtttt tttgggagtt tttttaaggt ttaataacta aggggaatat   3120

tttaaaatta agagagcagc aaatgaaagg agtaaagaaa aaaatagctg tcgggtagga   3180

tgccactgac tctgctatgt gatttatcag ggttttcatc tactgacttc tttctcatta   3240

ggtaggctta acaacttact tgagaatttt gcaactgtct atgcagctga atctaagtat   3300

ggttttttgt catattgcct ctagattttc ttctgtgctt ctctctatct gctctggaat   3360

ggatgagtga atgtgttctg ggtgttttag ggaacatatt gatagaaatg accaccttgc   3420

agacaaaatc tctctctctc tttttgtttt tatagaaaag aagtgatagt agttaattgg   3480

catcgatttt tcagatattg cactacctta taatggttgt ttttgatacc tgaaaattgt   3540

gcaaatgcca aatattaatt gtaagtcata tctgagaaat cattcttggc tgtctttcta   3600

ggtattccat agaatcaaca cattttaagg ctgaaagata ctgtcgaaat cacccagtcc   3660

caacccccca atttaaaatt gattctagta aaattaggtc cagtaacacc tgtatatatg   3720

tatatattta ataaagagta cttgtacaaa aaagcttatc ataaattatt tcatgaatgt   3780

gaatagattt ctggccttga ggacgatgtt tggaaatatg gttggaagca caattcattc   3840

gctactagtt attcagagcg tactttgttc caggaactat gctggaaact gatagttcac   3900

tattctgatg aaaaggctgg ttttgttgtt gttgttgttg ttgttgttgt tgtttttggt   3960

gaggaactct tactctttgc taatctattg gcctatctta agaaataatt atttggttat   4020

tcattggctt cctttaaaaa aaagtgttct tctacaaatc ttacagagtg taaagagata   4080

aaaagaaatg attttttttc ttacctttac atatgaaggt ttaaaaatac atcatgtggc   4140

caaagaatga gaaaggacag aattaaccaa ggattcttaa ttgttaattt gaagaacaca   4200

ttaaccagaa agcttaaaca ttattattaa aataaattat ttcatttgca cacaatgata   4260

ataatgatga taataataat aataataata ataataataa taataataat aatatgttgt   4320

ttgctttcct taactgaatt tcatcaaatt cattcagtga tttttatttt ggtcattatt   4380

tctatcttcc caataaccca gaggtacatc aagtaaaaac acttttgcaa agagccagtc   4440

acttttccct cttagaaaat ctcagaagaa tgattagggg cacccaaagt tctggttatc   4500

tatgaataat aatgaataat tttggctgag aatggtacct ttatataact cttttaaaga   4560

tgaaattcag aataatttta ttcaggacct agtatctgca gtccatgttg gccactaact   4620

gctacataat tactttcaat ttcctccagg catgactagg tataaacata tatttacatg   4680

attaatccac attttaaaat gacttgcact tgtgcatata catagtactt tgaataatgt   4740

atattttaaa ttggacctca caaatcttgt attaaagtag gtagagagta gagtcacact   4800

ttttttgatg aaatgagtca cagagaagtt acatgacaaa gataaaatca cagggttgga   4860

aagaactttg aaaggtcatt tttcaataat ctcaccttaa aagtgacccc ttttcaaaca   4920

aagcataaac aatttatttg tggcttattt tacccatgag ctggccaata cttcctggcc   4980

tagaaaaata tctccactct ccccattcct gttcttaatg gtcttctctt ctcaatttgt   5040

aaatattctc cagtaaaaga caccaggtgt ggagatgggt cacttaattt caagttctga   5100

gtgtcttgtg gttttaaaca agtctcttaa cctctctaag actgattcct catttataac   5160

agggaggagg tggattatgt aatatctaag agcttttcag ttttaatact ctctgattct   5220

catagtaaat acaagcatac tcttgtaaga aaaacactga atactttgaa ccacaaataa   5280

gtgtttatgg acaaaaattt agttctactg cttgattact ttaagttcat tgcttgcttc   5340

aaactaaggt ttccctacct tcaaaaatat atataacatc tctccattta gataaagtat   5400

attcttcccc agggaagact gtattcttta aagacagtag aatattggct atttctcttt   5460

tctgggattt cctgggcttt tattcactaa atgggctcct gcccagtttg ggtactgtgc   5520

tgatttttag atatacagag ataaaaatag cccctttcct tgcaggtagt cacagtccgg   5580

aagagatgat agatgcatag acaaaaaatt atgggatgta actaatgctt cagtagaata   5640

cagcagggcc aaaactagag tgatactcat ctcaggcaca aatatatatg gggacatcaa   5700

aacttcaata atcaagatac ctaatattta agtgaatatt tttaaaactc aaaattaatg   5760

caaaagattt atgatgaaca gaatatacaa attttaaata aattaataga atcagtagta   5820

ataatatttt cttctgcctc aggctccaaa attgctcagc atagcactga tctagataga   5880

ggtggataaa agatccacat aacttaatta cattgttgaa ggagaggaac aagagtgata   5940

gcagagaagg tttcacagat ataatcttaa gctaaatttt atagaatgat ttggagttct   6000

tatagcctcc attcccactt ccacaaacaa acaaaaaaat gaaagcgcaa ttttatcagc   6060

acctgaggca ggagaagaga tgaggatgtg gaaagtcaag gggaactctt actacaaatt   6120

cttagttctg tgtttggagg taagggtgaa tgcagggaag tgagagttgt tgatgttgga   6180

aagacctaaa gagcctggat taggaagagt tttgtgtaaa ttactgaagg aatggaattt   6240

gatcaggatt agtggcaatt tattaaaaat cttgaagaat aatacgatga aaactaacat   6300

ccttattttt ctgttttaga gaaagcacct gattattgtg tgaactatgg tttggagggc   6360

cacaaatcta gaggtagtgg aacagttgag atctcttatt ttttctttcc tgtcttaaac   6420

tttgccttct attccttttt tctttttttg accgcaatga cttcattgtc atttgtaaaa   6480

gtgatacatg actgttaaag atagacattg tagaaactta aaaacaatct caaaattcta   6540

ccacccagaa atcagaaata ttttgtattt ggatatgttt gtctagaaga gtagattgct   6600

tgattaaaag acagagtttt ataaatgtag aagccaatat gacatacatg ctgccattaa   6660

ataataaaaa attaaattga cttttatctc aagataagat taaaattgga gggtaaaact   6720

gaagaaattg ttgaaatttg gatggtgctt ctttaaagca agagatttag agagtcagag   6780

ctttttatcc caggtttcaa tctttatttc aggaaaattt tctgcaattt tgtctaagtt   6840

aatttttttt ttttaagaaa tgccaattat gtcaaatccc ttttgtctct atacaatagt   6900

ccccaactgt tttggcaaca ggcacgggtg agggtggggg aatggttttc agatgaaatt   6960

gttccatctc agatcatcag gcattagtcg attctcataa ggagcggaca accttgcatg   7020

ccctcctatg agaatctaat gccgccgcta atctgacagg aggcagagct caggcgataa   7080

tgctcaatgg gtgccactca cctcctgttg tgctgcccaa ttcctaacag gtcatggata   7140

agtactggtc agtggcccag gggttgggga ccactgctct gtaactattt acagtattct   7200

ttgtaactac tttggtatct ttaaaatttt ctttaacttt tgtcaaccat aaccctagtg   7260

agttttcagt tgtgattatt ctattttgta acttccaatg tacttttcaa cttcataatg   7320

gttaattttg ttttccattg ctttcttggt cactgtcatt tcatttttct tctctttctc   7380

tatttttacc attgctttat tgaaatatct tctttgagct tctcatgttt ctctattaat   7440

gagatcatgt ctataatatt ttttgagact acagagacct atttatataa actcttcctc   7500

tatttcttga aaaagttttt atctggcgtg agcttcatct gctttttcat tgaggtttta   7560

tctcccttgc ctatttttgg ggctggtttc tttctattaa tcactgagca gagccagcta   7620

tttactgaac tacagtgtgg gaagtggtgg gagggtgagt cagatcagcc cacagaagct   7680

atttaaattt caggtttcaa gcccacctcc ccaaaaccgt tttatgtgtt ttttcttctg   7740

cccaggcacc atatttttat atctattttt gacatttggg cggcctatgt agttcacagt   7800

gtaaaactct ctgttttact ttctttatgt tattgctagt gattattgct tgtagtccca   7860

cccccttccc cacattagcc ttagtattct atattattca gcaagcttgt tcacaactct   7920

caaatatagt ctatcagaat ttttatcttt acctctacat tccactattc ggaagtatat   7980

agtaaaatcg tatgaagaca gattttgtct ttttcttgcc tgtttacact ctatcttaca   8040

gaggtttcaa acaaaccatc tttgtttgaa acatcgcagg ataatgatac ttattgaaat   8100

ctacatcctg cccaagatat atgccagtca atttcctttc tcctattagt gcaaatggct   8160

acctacttaa aagctgctga ctatagtttg tc                                 8192


<210>  902
<211>  554
<212>  PRT
<213>  Homosapiens

<400>  902

Met Val Ser Ala Lys Lys Val Pro Ala Ile Ala Leu Ser Ala Gly Val 
1               5                   10                  15      


Ser Phe Ala Leu Leu Arg Phe Leu Cys Leu Ala Val Cys Leu Asn Glu 
            20                  25                  30          


Ser Pro Gly Gln Asn Gln Lys Glu Glu Lys Leu Cys Thr Glu Asn Phe 
        35                  40                  45              


Thr Arg Ile Leu Asp Ser Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg 
    50                  55                  60                  


Pro Gly Phe Gly Gly Pro Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
65                  70                  75                  80  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
                85                  90                  95      


Val Phe Phe Arg Gln Thr Trp Ile Asp Lys Arg Leu Lys Tyr Asp Gly 
            100                 105                 110         


Pro Ile Glu Ile Leu Arg Leu Asn Asn Met Met Val Thr Lys Val Trp 
        115                 120                 125             


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Val Ser His Asn 
    130                 135                 140                 


Met Thr Ala Pro Asn Lys Leu Phe Arg Ile Met Arg Asn Gly Thr Ile 
145                 150                 155                 160 


Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Arg Leu 
                165                 170                 175     


Val Asp Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
            180                 185                 190         


Tyr Ala Tyr Pro Lys Ser Glu Met Ile Tyr Thr Trp Thr Lys Gly Pro 
        195                 200                 205             


Glu Lys Ser Val Glu Val Pro Lys Glu Ser Ser Ser Leu Val Gln Tyr 
    210                 215                 220                 


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Ile Thr 
225                 230                 235                 240 


Gly Glu Tyr Ile Val Met Thr Val Tyr Phe His Leu Arg Arg Lys Met 
                245                 250                 255     


Gly Tyr Phe Met Ile Gln Thr Tyr Ile Pro Cys Ile Met Thr Val Ile 
            260                 265                 270         


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
        275                 280                 285             


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
    290                 295                 300                 


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
305                 310                 315                 320 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
                325                 330                 335     


Phe Ala Ala Val Asn Tyr Phe Thr Asn Ile Gln Met Glu Lys Ala Lys 
            340                 345                 350         


Arg Lys Thr Ser Lys Pro Pro Gln Glu Val Pro Ala Ala Pro Val Gln 
        355                 360                 365             


Arg Glu Lys His Pro Glu Ala Pro Leu Gln Asn Thr Asn Ala Asn Leu 
    370                 375                 380                 


Asn Met Arg Lys Arg Thr Asn Ala Leu Val His Ser Glu Ser Asp Val 
385                 390                 395                 400 


Gly Asn Arg Thr Glu Val Gly Asn His Ser Ser Lys Ser Ser Thr Val 
                405                 410                 415     


Val Gln Glu Ser Ser Lys Gly Thr Pro Arg Ser Tyr Leu Ala Ser Ser 
            420                 425                 430         


Pro Asn Pro Phe Ser Arg Ala Asn Ala Ala Glu Thr Ile Ser Ala Ala 
        435                 440                 445             


Arg Ala Leu Pro Ser Ala Ser Pro Thr Ser Ile Arg Thr Gly Tyr Met 
    450                 455                 460                 


Pro Arg Lys Ala Ser Val Gly Ser Ala Ser Thr Arg His Val Phe Gly 
465                 470                 475                 480 


Ser Arg Leu Gln Arg Ile Lys Thr Thr Val Asn Thr Ile Gly Ala Thr 
                485                 490                 495     


Gly Lys Leu Ser Ala Thr Pro Pro Pro Ser Ala Pro Pro Pro Ser Gly 
            500                 505                 510         


Ser Gly Thr Ser Lys Ile Asp Lys Tyr Ala Arg Ile Leu Phe Pro Val 
        515                 520                 525             


Thr Phe Gly Ala Phe Asn Met Val Tyr Trp Val Val Tyr Leu Ser Lys 
    530                 535                 540                 


Asp Thr Met Glu Lys Ser Glu Ser Leu Met 
545                 550                 


<210>  903
<211>  5084
<212>  DNA
<213>  Homosapiens

<400>  903
gatcccatcg cagctaccgc gatgagaggc gctcgcggcg cctgggattt tctctgcgtt     60

ctgctcctac tgcttcgcgt ccagacaggc tcttctcaac catctgtgag tccaggggaa    120

ccgtctccac catccatcca tccaggaaaa tcagacttaa tagtccgcgt gggcgacgag    180

attaggctgt tatgcactga tccgggcttt gtcaaatgga cttttgagat cctggatgaa    240

acgaatgaga ataagcagaa tgaatggatc acggaaaagg cagaagccac caacaccggc    300

aaatacacgt gcaccaacaa acacggctta agcaattcca tttatgtgtt tgttagagat    360

cctgccaagc ttttccttgt tgaccgctcc ttgtatggga aagaagacaa cgacacgctg    420

gtccgctgtc ctctcacaga cccagaagtg accaattatt ccctcaaggg gtgccagggg    480

aagcctcttc ccaaggactt gaggtttatt cctgacccca aggcgggcat catgatcaaa    540

agtgtgaaac gcgcctacca tcggctctgt ctgcattgtt ctgtggacca ggagggcaag    600

tcagtgctgt cggaaaaatt catcctgaaa gtgaggccag ccttcaaagc tgtgcctgtt    660

gtgtctgtgt ccaaagcaag ctatcttctt agggaagggg aagaattcac agtgacgtgc    720

acaataaaag atgtgtctag ttctgtgtac tcaacgtgga aaagagaaaa cagtcagact    780

aaactacagg agaaatataa tagctggcat cacggtgact tcaattatga acgtcaggca    840

acgttgacta tcagttcagc gagagttaat gattctggag tgttcatgtg ttatgccaat    900

aatacttttg gatcagcaaa tgtcacaaca accttggaag tagtagataa aggattcatt    960

aatatcttcc ccatgataaa cactacagta tttgtaaacg atggagaaaa tgtagatttg   1020

attgttgaat atgaagcatt ccccaaacct gaacaccagc agtggatcta tatgaacaga   1080

accttcactg ataaatggga agattatccc aagtctgaga atgaaagtaa tatcagatac   1140

gtaagtgaac ttcatctaac gagattaaaa ggcaccgaag gaggcactta cacattccta   1200

gtgtccaatt ctgacgtcaa tgctgccata gcatttaatg tttatgtgaa tacaaaacca   1260

gaaatcctga cttacgacag gctcgtgaat ggcatgctcc aatgtgtggc agcaggattc   1320

ccagagccca caatagattg gtatttttgt ccaggaactg agcagagatg ctctgcttct   1380

gtactgccag tggatgtgca gacactaaac tcatctgggc caccgtttgg aaagctagtg   1440

gttcagagtt ctatagattc tagtgcattc aagcacaatg gcacggttga atgtaaggct   1500

tacaacgatg tgggcaagac ttctgcctat tttaactttg catttaaagg taacaacaaa   1560

gagcaaatcc atccccacac cctgttcact cctttgctga ttggtttcgt aatcgtagct   1620

ggcatgatgt gcattattgt gatgattctg acctacaaat atttacagaa acccatgtat   1680

gaagtacagt ggaaggttgt tgaggagata aatggaaaca attatgttta catagaccca   1740

acacaacttc cttatgatca caaatgggag tttcccagaa acaggctgag ttttgggaaa   1800

accctgggtg ctggagcttt cgggaaggtt gttgaggcaa ctgcttatgg cttaattaag   1860

tcagatgcgg ccatgactgt cgctgtaaag atgctcaagc cgagtgccca tttgacagaa   1920

cgggaagccc tcatgtctga actcaaagtc ctgagttacc ttggtaatca catgaatatt   1980

gtgaatctac ttggagcctg caccattgga gggcccaccc tggtcattac agaatattgt   2040

tgctatggtg atcttttgaa ttttttgaga agaaaacgtg attcatttat ttgttcaaag   2100

caggaagatc atgcagaagc tgcactttat aagaatcttc tgcattcaaa ggagtcttcc   2160

tgcagcgata gtactaatga gtacatggac atgaaacctg gagtttctta tgttgtccca   2220

accaaggccg acaaaaggag atctgtgaga ataggctcat acatagaaag agatgtgact   2280

cccgccatca tggaggatga cgagttggcc ctagacttag aagacttgct gagcttttct   2340

taccaggtgg caaagggcat ggctttcctc gcctccaaga attgtattca cagagacttg   2400

gcagccagaa atatcctcct tactcatggt cggatcacaa agatttgtga ttttggtcta   2460

gccagagaca tcaagaatga ttctaattat gtggttaaag gaaacgctcg actacctgtg   2520

aagtggatgg cacctgaaag cattttcaac tgtgtataca cgtttgaaag tgacgtctgg   2580

tcctatggga tttttctttg ggagctgttc tctttaggaa gcagccccta tcctggaatg   2640

ccggtcgatt ctaagttcta caagatgatc aaggaaggct tccggatgct cagccctgaa   2700

cacgcacctg ctgaaatgta tgacataatg aagacttgct gggatgcaga tcccctaaaa   2760

agaccaacat tcaagcaaat tgttcagcta attgagaagc agatttcaga gagcaccaat   2820

catatttact ccaacttagc aaactgcagc cccaaccgac agaagcccgt ggtagaccat   2880

tctgtgcgga tcaattctgt cggcagcacc gcttcctcct cccagcctct gcttgtgcac   2940

gacgatgtct gagcagaatc agtgtttggg tcacccctcc aggaatgatc tcttcttttg   3000

gcttccatga tggttatttt cttttctttc aacttgcatc caactccagg atagtgggca   3060

ccccactgca atcctgtctt tctgagcaca ctttagtggc cgatgatttt tgtcatcagc   3120

caccatccta ttgcaaaggt tccaactgta tatattccca atagcaacgt agcttctacc   3180

atgaacagaa aacattctga tttggaaaaa gagagggagg tatggactgg gggccagagt   3240

cctttccaag gcttctccaa ttctgcccaa aaatatggtt gatagtttac ctgaataaat   3300

ggtagtaatc acagttggcc ttcagaacca tccatagtag tatgatgata caagattaga   3360

agctgaaaac ctaagtcctt tatgtggaaa acagaacatc attagaacaa aggacagagt   3420

atgaacacct gggcttaaga aatctagtat ttcatgctgg gaatgagaca taggccatga   3480

aaaaaatgat ccccaagtgt gaacaaaaga tgctcttctg tggaccactg catgagcttt   3540

tatactaccg acctggtttt taaatagagt ttgctattag agcattgaat tggagagaag   3600

gcctccctag ccagcacttg tatatacgca tctataaatt gtccgtgttc atacatttga   3660

ggggaaaaca ccataaggtt tcgtttctgt atacaaccct ggcattatgt ccactgtgta   3720

tagaagtaga ttaagagcca tataagtttg aaggaaacag ttaataccat tttttaagga   3780

aacaatataa ccacaaagca cagtttgaac aaaatctcct cttttagctg atgaacttat   3840

tctgtagatt ctgtggaaca agcctatcag cttcagaatg gcattgtact caatggattt   3900

gatgctgttt gacaaagtta ctgattcact gcatggctcc cacaggagtg ggaaaacact   3960

gccatcttag tttggattct tatgtagcag gaaataaagt ataggtttag cctccttcgc   4020

aggcatgtcc tggacaccgg gccagtatct atatatgtgt atgtacgttt gtatgtgtgt   4080

agacaaatat ttggaggggt atttttgccc tgagtccaag agggtccttt agtacctgaa   4140

aagtaacttg gctttcatta ttagtactgc tcttgtttct tttcacatag ctgtctagag   4200

tagcttacca gaagcttcca tagtggtgca gaggaagtgg aaggcatcag tccctatgta   4260

tttgcagttc acctgcactt aaggcactct gttatttaga ctcatcttac tgtacctgtt   4320

ccttagacct tccataatgc tactgtctca ctgaaacatt taaattttac cctttagact   4380

gtagcctgga tattattctt gtagtttacc tctttaaaaa caaaacaaaa caaaacaaaa   4440

aactcccctt cctcactgcc caatataaaa ggcaaatgtg tacatggcag agtttgtgtg   4500

ttgtcttgaa agattcaggt atgttgcctt tatggtttcc cccttctaca tttcttagac   4560

tacatttaga gaactgtggc cgttatctgg aagtaaccat ttgcactgga gttctatgct   4620

ctcgcacctt tccaaagtta acagattttg gggttgtgtt gtcacccaag agattgttgt   4680

ttgccatact ttgtctgaaa aattcctttg tgtttctatt gacttcaatg atagtaagaa   4740

aagtggttgt tagttataga tgtctaggta cttcaggggc acttcattga gagttttgtc   4800

ttgccatact ttgtctgaaa aattcctttg tgtttctatt gacttcaatg atagtaagaa   4860

aagtggttgt tagttataga tgtctaggta cttcaggggc acttcattga gagttttgtc   4920

aatgtctttt gaatattccc aagcccatga gtccttgaaa atatttttta tatatacagt   4980

aactttatgt gtaaatacat aagcggcgta agtttaaagg atgttggtgt tccacgtgtt   5040

ttattcctgt atgttgtcca attgttgaca gttctgaaga attc                    5084


<210>  904
<211>  976
<212>  PRT
<213>  Homosapiens

<400>  904

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  905
<211>  5830
<212>  DNA
<213>  Homosapiens

<400>  905
actgagtccc gggaccccgg gagagcggtc agtgtgtggt cgctgcgttt cctctgcctg     60

cgccgggcat cacttgcgcg ccgcagaaag tccgtctggc agcctggata tcctctccta    120

ccggcacccg cagacgcccc tgcagccgcc ggtcggcgcc cgggctccct agccctgtgc    180

gctcaactgt cctgcgctgc ggggtgccgc gagttccacc tccgcgcctc cttctctaga    240

caggcgctgg gagaaagaac cggctcccga gttctgggca tttcgcccgg ctcgaggtgc    300

aggatgcaga gcaaggtgct gctggccgtc gccctgtggc tctgcgtgga gacccgggcc    360

gcctctgtgg gtttgcctag tgtttctctt gatctgccca ggctcagcat acaaaaagac    420

atacttacaa ttaaggctaa tacaactctt caaattactt gcaggggaca gagggacttg    480

gactggcttt ggcccaataa tcagagtggc agtgagcaaa gggtggaggt gactgagtgc    540

agcgatggcc tcttctgtaa gacactcaca attccaaaag tgatcggaaa tgacactgga    600

gcctacaagt gcttctaccg ggaaactgac ttggcctcgg tcatttatgt ctatgttcaa    660

gattacagat ctccatttat tgcttctgtt agtgaccaac atggagtcgt gtacattact    720

gagaacaaaa acaaaactgt ggtgattcca tgtctcgggt ccatttcaaa tctcaacgtg    780

tcactttgtg caagataccc agaaaagaga tttgttcctg atggtaacag aatttcctgg    840

gacagcaaga agggctttac tattcccagc tacatgatca gctatgctgg catggtcttc    900

tgtgaagcaa aaattaatga tgaaagttac cagtctatta tgtacatagt tgtcgttgta    960

gggtatagga tttatgatgt ggttctgagt ccgtctcatg gaattgaact atctgttgga   1020

gaaaagcttg tcttaaattg tacagcaaga actgaactaa atgtggggat tgacttcaac   1080

tgggaatacc cttcttcgaa gcatcagcat aagaaacttg taaaccgaga cctaaaaacc   1140

cagtctggga gtgagatgaa gaaatttttg agcaccttaa ctatagatgg tgtaacccgg   1200

agtgaccaag gattgtacac ctgtgcagca tccagtgggc tgatgaccaa gaagaacagc   1260

acatttgtca gggtccatga aaaacctttt gttgcttttg gaagtggcat ggaatctctg   1320

gtggaagcca cggtggggga gcgtgtcaga atccctgcga agtaccttgg ttacccaccc   1380

ccagaaataa aatggtataa aaatggaata ccccttgagt ccaatcacac aattaaagcg   1440

gggcatgtac tgacgattat ggaagtgagt gaaagagaca caggaaatta cactgtcatc   1500

cttaccaatc ccatttcaaa ggagaagcag agccatgtgg tctctctggt tgtgtatgtc   1560

ccaccccaga ttggtgagaa atctctaatc tctcctgtgg attcctacca gtacggcacc   1620

actcaaacgc tgacatgtac ggtctatgcc attcctcccc cgcatcacat ccactggtat   1680

tggcagttgg aggaagagtg cgccaacgag cccagccaag ctgtctcagt gacaaaccca   1740

tacccttgtg aagaatggag aagtgtggag gacttccagg gaggaaataa aattgaagtt   1800

aataaaaatc aatttgctct aattgaagga aaaaacaaaa ctgtaagtac ccttgttatc   1860

caagcggcaa atgtgtcagc tttgtacaaa tgtgaagcgg tcaacaaagt cgggagagga   1920

gagagggtga tctccttcca cgtgaccagg ggtcctgaaa ttactttgca acctgacatg   1980

cagcccactg agcaggagag cgtgtctttg tggtgcactg cagacagatc tacgtttgag   2040

aacctcacat ggtacaagct tggcccacag cctctgccaa tccatgtggg agagttgccc   2100

acacctgttt gcaagaactt ggatactctt tggaaattga atgccaccat gttctctaat   2160

agcacaaatg acattttgat catggagctt aagaatgcat ccttgcagga ccaaggagac   2220

tatgtctgcc ttgctcaaga caggaagacc aagaaaagac attgcgtggt caggcagctc   2280

acagtcctag agcgtgtggc acccacgatc acaggaaacc tggagaatca gacgacaagt   2340

attggggaaa gcatcgaagt ctcatgcacg gcatctggga atccccctcc acagatcatg   2400

tggtttaaag ataatgagac ccttgtagaa gactcaggca ttgtattgaa ggatgggaac   2460

cggaacctca ctatccgcag agtgaggaag gaggacgaag gcctctacac ctgccaggca   2520

tgcagtgttc ttggctgtgc aaaagtggag gcatttttca taatagaagg tgcccaggaa   2580

aagacgaact tggaaatcat tattctagta ggcacggcgg tgattgccat gttcttctgg   2640

ctacttcttg tcatcatcct acggaccgtt aagcgggcca atggagggga actgaagaca   2700

ggctacttgt ccatcgtcat ggatccagat gaactcccat tggatgaaca ttgtgaacga   2760

ctgccttatg atgccagcaa atgggaattc cccagagacc ggctgaagct aggtaagcct   2820

cttggccgtg gtgcctttgg ccaagtgatt gaagcagatg cctttggaat tgacaagaca   2880

gcaacttgca ggacagtagc agtcaaaatg ttgaaagaag gagcaacaca cagtgagcat   2940

cgagctctca tgtctgaact caagatcctc attcatattg gtcaccatct caatgtggtc   3000

aaccttctag gtgcctgtac caagccagga gggccactca tggtgattgt ggaattctgc   3060

aaatttggaa acctgtccac ttacctgagg agcaagagaa atgaatttgt cccctacaag   3120

accaaagggg cacgattccg tcaagggaaa gactacgttg gagcaatccc tgtggatctg   3180

aaacggcgct tggacagcat caccagtagc cagagctcag ccagctctgg atttgtggag   3240

gagaagtccc tcagtgatgt agaagaagag gaagctcctg aagatctgta taaggacttc   3300

ctgaccttgg agcatctcat ctgttacagc ttccaagtgg ctaagggcat ggagttcttg   3360

gcatcgcgaa agtgtatcca cagggacctg gcggcacgaa atatcctctt atcggagaag   3420

aacgtggtta aaatctgtga ctttggcttg gcccgggata tttataaaga tccagattat   3480

gtcagaaaag gagatgctcg cctccctttg aaatggatgg ccccagaaac aatttttgac   3540

agagtgtaca caatccagag tgacgtctgg tcttttggtg ttttgctgtg ggaaatattt   3600

tccttaggtg cttctccata tcctggggta aagattgatg aagaattttg taggcgattg   3660

aaagaaggaa ctagaatgag ggcccctgat tatactacac cagaaatgta ccagaccatg   3720

ctggactgct ggcacgggga gcccagtcag agacccacgt tttcagagtt ggtggaacat   3780

ttgggaaatc tcttgcaagc taatgctcag caggatggca aagactacat tgttcttccg   3840

atatcagaga ctttgagcat ggaagaggat tctggactct ctctgcctac ctcacctgtt   3900

tcctgtatgg aggaggagga agtatgtgac cccaaattcc attatgacaa cacagcagga   3960

atcagtcagt atctgcagaa cagtaagcga aagagccggc ctgtgagtgt aaaaacattt   4020

gaagatatcc cgttagaaga accagaagta aaagtaatcc cagatgacaa ccagacggac   4080

agtggtatgg ttcttgcctc agaagagctg aaaactttgg aagacagaac caaattatct   4140

ccatcttttg gtggaatggt gcccagcaaa agcagggagt ctgtggcatc tgaaggctca   4200

aaccagacaa gcggctacca gtccggatat cactccgatg acacagacac caccgtgtac   4260

tccagtgagg aagcagaact tttaaagctg atagagattg gagtgcaaac cggtagcaca   4320

gcccagattc tccagcctga ctcggggacc acactgagct ctcctcctgt ttaaaaggaa   4380

gcatccacac cccaactccc ggacatcaca tgagaggtct gctcagattt tgaagtgttg   4440

ttctttccac cagcaggaag tagccgcatt tgattttcat ttcgacaaca gaaaaaggac   4500

ctcggactgc agggagccag tcttctaggc atatcctgga agaggcttgt gacccaagaa   4560

tgtgtctgtg tcttctccca gtgttgacct gatcctcttt tttcattcat ttaaaaagca   4620

ttatcatgcc cctgctgcgg gtctcaccat gggtttagaa caaagagctt caagcaatgg   4680

ccccatcctc aaagaagtag cagtacctgg ggagctgaca cttctgtaaa actagaagat   4740

aaaccaggca acgtaagtgt tcgaggtgtt gaagatggga aggatttgca gggctgagtc   4800

tatccaagag gctttgttta ggacgtgggt cccaagccaa gccttaagtg tggaattcgg   4860

attgatagaa aggaagacta acgttacctt gctttggaga gtactggagc ctgcaaatgc   4920

attgtgtttg ctctggtgga ggtgggcatg gggtctgttc tgaaatgtaa agggttcaga   4980

cggggtttct ggttttagaa ggttgcgtgt tcttcgagtt gggctaaagt agagttcgtt   5040

gtgctgtttc tgactcctaa tgagagttcc ttccagaccg ttagctgtct ccttgccaag   5100

ccccaggaag aaaatgatgc agctctggct ccttgtctcc caggctgatc ctttattcag   5160

aataccacaa agaaaggaca ttcagctcaa ggctccctgc cgtgttgaag agttctgact   5220

gcacaaacca gcttctggtt tcttctggaa tgaataccct catatctgtc ctgatgtgat   5280

atgtctgaga ctgaatgcgg gaggttcaat gtgaagctgt gtgtggtgtc aaagtttcag   5340

gaaggatttt acccttttgt tcttccccct gtccccaacc cactctcacc ccgcaaccca   5400

tcagtatttt agttatttgg cctctactcc agtaaacctg attgggtttg ttcactctct   5460

gaatgattat tagccagact tcaaaattat tttatagccc aaattataac atctattgta   5520

ttatttagac ttttaacata tagagctatt tctactgatt tttgcccttg ttctgtcctt   5580

tttttcaaaa aagaaaatgt gttttttgtt tggtaccata gtgtgaaatg ctgggaacaa   5640

tgactataag acatgctatg gcacatatat ttatagtctg tttatgtaga aacaaatgta   5700

atatattaaa gccttatata taatgaactt tgtactattc acattttgta tcagtattat   5760

gtagcataac aaaggtcata atgctttcag caattgatgt cattttatta aagaacattg   5820

aaaaacttga                                                          5830


<210>  906
<211>  1356
<212>  PRT
<213>  Homosapiens

<400>  906

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  907
<211>  2271
<212>  DNA
<213>  Homosapiens

<400>  907
gaggctgaga ccggtgcgcc gcgcgctagt ggccgctctt ccgcgggcta gcgggcggtg     60

ggggcgccag cagcgcggaa ggcgggcacg cgggccatgg ctccctgggc ggaggccgag    120

cactcggcgc tgaacccgct gcgcgcggtg tggctcacgc tgaccgccgc cttcctgctg    180

accctactgc tgcagctcct gccgcccggc ctgctcccgg gctgcgcgat cttccaggac    240

ctgatccgct atgggaaaac caagtgtggg gagccgtcgc gccccgccgc ctgccgagcc    300

tttgatgtcc ccaagagata tttttcccac ttttatatca tctcagtgct gtggaatggc    360

ttcctgcttt ggtgccttac tcaatctctg ttcctgggag caccttttcc aagctggctt    420

catggtttgc tcagaattct cggggcggca cagttccagg gaggggagct ggcactgtct    480

gcattcttag tgctagtatt tctgtggctg cacagcttac gaagactctt cgagtgcctc    540

tacgtcagtg tcttctccaa tgtcatgatt cacgtcgtgc agtactgttt tggacttgtc    600

tattatgtcc ttgttggcct aactgtgctg agccaagtgc caatggatgg caggaatgcc    660

tacataacag ggaaaaatct attgatgcaa gcacggtggt tccatattct tgggatgatg    720

atgttcatct ggtcatctgc ccatcagtat aagtgccatg ttattctcgg caatctcagg    780

aaaaataaag caggagtggt cattcactgt aaccacagga tcccatttgg agactggttt    840

gaatatgttt cttcccctaa ctacttagca gagctgatga tctacgtttc catggccgtc    900

acctttgggt tccacaactt aacttggtgg ctagtggtga caaatgtctt ctttaatcag    960

gccctgtctg cctttctcag ccaccaattc tacaaaagca aatttgtctc ttacccgaag   1020

cataggaaag ctttcctacc atttttgttt taagttaacc tcagtcatga agaatgcaaa   1080

ccaggtgatg gtttcaatgc ctaaggacag tgaagtctgg agcccaaagt acagtttcag   1140

caaagctgtt tgaaactctc cattccattt ctatacccca caagttttca ctgaatgagc   1200

atggcagtgc cactcaagaa aatgaatctc caaagtatct tcaaagaata aatactaatg   1260

gcagatctgc gatttctggg tccactttct gagatgcttt ctaaaaccaa ccaactgata   1320

aaaagtagat gagacttctc caagctgctt cacaagcaaa ctaaccgaaa aactgaaaat   1380

atacaaacag cttcacacac acacacacac acacacacac acacacacac acaaaggaag   1440

atcatcaatg gctgcggtag cctagtagga atggactata taataatata gcaggtgctc   1500

aataactgtt tgttgcattt cagtaaaagc agaataacct ttcaaaataa taacaggctg   1560

ggtgcaatgg ctcacacctg ttaatcccag cacttcggga ggccaaggtg ggcagttcgc   1620

ttgggcccaa gagttcgaga ccagcctggg caacatggtg aaaccctatc tccgtgaaaa   1680

aatatgaaaa ttagccaaga gtggtggcac atgcctgtag tcccagatac ttgggagtgg   1740

gctgggatgg gagaatcgct tgagcccagg aggtcaaggg tacagtgagc cgaggtcatg   1800

ccactgcact ccagcctggc ctgggcaaca gagcaagacc ctgtctcaaa ataataataa   1860

tatataattt tacaccaaaa gtttcaggaa aaaacgagtt tgttggagtt agtttatact   1920

ttcacatatc accacaaaga tctccagtta aataactatc aatatccatt tccattcatc   1980

tccccctcaa atcatagcct aacagaacac tttgaaagct cttttattta atattttttt   2040

acatcctttg aagggagtgc ttcaaaaatg aaagcatcag aagataaaat atttttatat   2100

ttatgcatag caagccttca tgaacggaag tgacacactc tggattgaat aatactgtag   2160

cctcattcat atgtagttat tcaaattgga ttaatgtctg tgtgagttta tttgaactag   2220

cagaaagtat ctgaagatat tcaggaatag agtttatact taaaatagct t            2271


<210>  908
<211>  318
<212>  PRT
<213>  Homosapiens

<400>  908

Met Ala Pro Trp Ala Glu Ala Glu His Ser Ala Leu Asn Pro Leu Arg 
1               5                   10                  15      


Ala Val Trp Leu Thr Leu Thr Ala Ala Phe Leu Leu Thr Leu Leu Leu 
            20                  25                  30          


Gln Leu Leu Pro Pro Gly Leu Leu Pro Gly Cys Ala Ile Phe Gln Asp 
        35                  40                  45              


Leu Ile Arg Tyr Gly Lys Thr Lys Cys Gly Glu Pro Ser Arg Pro Ala 
    50                  55                  60                  


Ala Cys Arg Ala Phe Asp Val Pro Lys Arg Tyr Phe Ser His Phe Tyr 
65                  70                  75                  80  


Ile Ile Ser Val Leu Trp Asn Gly Phe Leu Leu Trp Cys Leu Thr Gln 
                85                  90                  95      


Ser Leu Phe Leu Gly Ala Pro Phe Pro Ser Trp Leu His Gly Leu Leu 
            100                 105                 110         


Arg Ile Leu Gly Ala Ala Gln Phe Gln Gly Gly Glu Leu Ala Leu Ser 
        115                 120                 125             


Ala Phe Leu Val Leu Val Phe Leu Trp Leu His Ser Leu Arg Arg Leu 
    130                 135                 140                 


Phe Glu Cys Leu Tyr Val Ser Val Phe Ser Asn Val Met Ile His Val 
145                 150                 155                 160 


Val Gln Tyr Cys Phe Gly Leu Val Tyr Tyr Val Leu Val Gly Leu Thr 
                165                 170                 175     


Val Leu Ser Gln Val Pro Met Asp Gly Arg Asn Ala Tyr Ile Thr Gly 
            180                 185                 190         


Lys Asn Leu Leu Met Gln Ala Arg Trp Phe His Ile Leu Gly Met Met 
        195                 200                 205             


Met Phe Ile Trp Ser Ser Ala His Gln Tyr Lys Cys His Val Ile Leu 
    210                 215                 220                 


Gly Asn Leu Arg Lys Asn Lys Ala Gly Val Val Ile His Cys Asn His 
225                 230                 235                 240 


Arg Ile Pro Phe Gly Asp Trp Phe Glu Tyr Val Ser Ser Pro Asn Tyr 
                245                 250                 255     


Leu Ala Glu Leu Met Ile Tyr Val Ser Met Ala Val Thr Phe Gly Phe 
            260                 265                 270         


His Asn Leu Thr Trp Trp Leu Val Val Thr Asn Val Phe Phe Asn Gln 
        275                 280                 285             


Ala Leu Ser Ala Phe Leu Ser His Gln Phe Tyr Lys Ser Lys Phe Val 
    290                 295                 300                 


Ser Tyr Pro Lys His Arg Lys Ala Phe Leu Pro Phe Leu Phe 
305                 310                 315             


<210>  909
<211>  5687
<212>  DNA
<213>  Homosapiens

<400>  909
aatcgtccgc cgctcccgtt accggggcaa ccgcggcgcc tcctccgtgt cggccccgat     60

cgtccctccg cgccattttc aaactgctct agcgccggag cccgtgcctg gacggaagga    120

gctagtgggg gactcgaggc ctgagggcaa tgcggctgga ggcggaggca acggcggctg    180

gagctgccgg actttaattt ttggaagtga ataaaacttg ttttagaaga cgagatgact    240

acagctgtag agagaaagta tattaatatt aggaaaaggc tggatcagct gggataccgc    300

cagactctga cagtggagtg tttacctttg gtagaaaaac ttttcagcga cttagttcat    360

acaactgaga gccttcggca atcaaaatta tctgctgtga aagctgaaaa agaaagtgcc    420

aattttgatt ttgttttgga accctataaa cttgaaaatg caagattgag tagagaaaat    480

aatgaattat acctagagtt aatgaaactg agagaacatt cagaccaaca cgttaaagag    540

ttgaaaactt cattgaagaa atgtgcacgt gaaacagctg atctgaaatt tctgaataac    600

caatatgctc ataaactcaa actgttggag aaagagagca aagctaagaa tgaaagaatt    660

caacaacttc aagaaaagaa tttgcatgct gtagtacaaa ctccaggtgg caagaaaaga    720

agtattgctt tcaggcgcca gcgtatgcaa attgatgaac cggttcctcc ctctgaagtc    780

agttcatatc cagttcctca accagatgac ccttacattg cagacctcct tcaagtggct    840

gataacagga ttcaagaact tcaacaggaa gtccaccagc tacaagaaaa gttagcaatg    900

atggaaagtg gggtgagaga ctatagcaag cagattgagc taagagaacg agagatagaa    960

cgactgtcag ttgctttgga tggtggtcgg tcccctgatg tcctttctct ggagtctaga   1020

aataaaacca atgaaaagct tattgctcat ttaaatattc aggttgactt tcttcagcaa   1080

gctaataaag acctggagaa gcgtatacga gagcttatgg aaaccaagga aacagtgaca   1140

tctgaagtcg ttaatttaag taacaaaaat gaaaaactct gccaagaatt aactgaaata   1200

gatcagttag cacagcagtt ggaaagacat aaagaagaag tgcttgagac tgctgataaa   1260

gagcttgggg aagcaaagaa agagattaaa agaaagctct ctgaaatgca ggatcttgaa   1320

gaaacaatgg caaaacttca gctggaattg aacttatgcc agaaagaaaa ggagagactg   1380

agtgatgaac tccttgtaaa atcagaccta gaaactgttg ttcatcagct tgaacaagaa   1440

aagcaaagac ttagcaaaaa agttgaaagt tttgcagtta cagaacgaca acttactctg   1500

gaggttgaga ggatgagact agaacatgga ataaaacgtc gagacaggtc accttctcgt   1560

ttagatacat ttctgaaagg tatagaagaa gaacgagatt attataagaa agagctagag   1620

agactccaac atataataca gcgaagatct tgctctacaa gttatagcgc acgtgaaaaa   1680

agttcaatat ttagaacacc agaaaagggt gattacaatt cagaaattca tcagatcaca   1740

agagaaagag atgaacttca gcgtatgcta gaaagatttg aaaaatatat ggaagatata   1800

cagtccaatg ttaaattatt gacagcagaa agagataaac taagtgtctt atataatgaa   1860

gctcaggaag aattatctgc cctaagaaag gaatccaccc aaaccacagc accccataat   1920

attgttagtc ttatggaaaa ggaaaaagaa cttgcgttat ctgacttaag aagaattatg   1980

gcagaaaagg aagctttaag agaaaaatta gagcatattg aagaagtgag tctttttgga   2040

aaatcagaat tagagaaaac tattgaacat ttgacatgtg ttaatcatca gcttgaaagc   2100

gaaaaatatg aattaaagtc taaagtgtta ataatgaaag aaacaataga gtcgttagag   2160

aacaaattaa aagtccaagc tcaaaaattt agccatgtgg ctggtgactc atctcatcag   2220

aaaacagagg tgaactcact taggatagtg aatgagcagc tacagcggtc agttgatgac   2280

tatcagcacc gactttccat aaaaagaggt gaacttgaat cagcccaagc acaaattaaa   2340

atactggagg aaaagataga tgaactaaac cttaagatga cttcacagga tgaggaggct   2400

catgtaatga aaaagaccat tggtgttatt gataaagaaa aagactttct ccaggagact   2460

gtagatgaga agacagaaaa gattgcaaat ttgcaagaaa acctagctaa taaagaaaaa   2520

gctgttgctc aaatgaagat aatgatctca gagtgtgaat catctgtgaa ccagctgaaa   2580

gaaacattgg ttaatcgaga tcgtgagata aacagcctcc ggcgccagct tgatgcagct   2640

cacaaagaac tcgatgaagt aggaagatct agagaaatcg cttttaagga aaacagaaga   2700

ctgcaagatg acctggctac aatggcaaga gaaaatcaag aaatctcatt ggaattggaa   2760

gcagcagtgc aagaaaaaga agaaatgaag agcagagttc ataaatacat aacagaggtg   2820

tcacgatggg agagcttaat ggctgccaag gaaaaagaaa atcaagattt gttagataga   2880

tttcagatgc ttcataaccg tgctgaagac tgggaggtca aagcccatca agctgaggga   2940

gaaagcagct cagttcgact ggaacttctt tctattgaca ctgagaggag acatcttcga   3000

gaaagagtgg agctattaga aaaagaaatt caagagcaca taaatgccca tcatgcttat   3060

gaatctcaga tctcatcaat ggcaaaagcc atgtctcgat tagaagaaga gctgagacat   3120

caagaagatg agaaagcaac agtattaaat gacttgtcat ctcttagaga actttgcatt   3180

aaacttgatt caggcaaaga tattatgacc cagcaattga attcgaaaaa ccttgagttt   3240

gagagggttg tggtggaatt agaaaatgta aagtcagagt cagacctact gaaaaaacaa   3300

ctttcaaatg agagacatac agttaaaaac ctcgaatcat tgttggctac aaacagagat   3360

aaagaatttc attctcactt aacctcccac gagaaggata cagaaatcca gctacttaag   3420

gagaagttaa ccctttctga aagcaaatta actagtcaaa gccgggaaaa caccatgctt   3480

cgagctaaag tggcacagtt acaaacagat tatgatgctc tgaaaaggca gatctcaact   3540

gaaagatacg aacgagaacg agcaatccaa gagatgcgtc gacatggtct tgctacacca   3600

ccccttagtt ccactctgag gtctccttca cattctcctg aacatagaaa tgtgtaatta   3660

tcagaaagaa taatggcttt caatgagttc ctatgtggat ttttaaaaga acagaacagt   3720

aatgaaatat ttgaagtact tgttgctgaa aatcatgaac atggacacaa attctacctc   3780

tgtcaacttt tatttaaatc agtgaatatg ttaaaaagtt tggtttaaaa gaactatatc   3840

tatatgtata ttttcatata tatgacagaa caagaatatg tattaatagt gcctaatgta   3900

tctatatttt tattattcat gaattaaatt actaaaagta tgtttatact gtgaattaat   3960

ataatgtatt cacattattc tttaataatc tgtttattaa taagccatga tatgtgtatg   4020

taaatattct tacagtactt gtttttagtt gtcatgccta tgtttagacc atatcttaat   4080

gtattcacaa agaattatca actttgatgc tatgctgtca tgcttaactt tttcttctta   4140

aaattattca tagatctact gtctgttgtc aaggggaata tattcaggtc tagtcttctt   4200

ataatagcag aggtcttggt aaaataacta ccatatataa cgtgttattg ccatctagaa   4260

gaactatgat gagaaagata catttatata ttatgtaaaa tgttaactat catcatatgg   4320

actctatgta acacaaattc aaaagcaaac taaaagctat atgcagagtt ttgtataaaa   4380

caatagaaca gaaatttggg acatttttct aggaaataaa attcctcggt gtattaatct   4440

aaggtttcaa agtataaaag tatatggggt aggccgggtg cagtggctca cgcctgtaat   4500

cccagcactt tgggaggccg aggcgagtgg atttcctaag gtcaggagtt tgagaccagc   4560

ctgagcaatg tggtgaaacc ccatctctac taaaaataca aaaattatct gggcttggtg   4620

gcgggcacct gtaatcccag ccacttggga ggctgaggca ggagaattgc ttgaacccgg   4680

gaggtggagg ctgcggtgag ccaagatcat gccattgcac tccagcctgg gtgacagagt   4740

aacactctgt ctcagaaaaa aaaaaaaaga aaaatatatg gggtaaatac agtaaaacgt   4800

tttgttaaat tccaatatac attcagtgat accactcttt ttcttctaag cctgtgtgtt   4860

ataatttacc agttccccaa aatgccattt ttaacgccga actgtgtaat atacatggaa   4920

aacagctttt tacaattaat tttcaaagtt gtaattttaa agaatttggg tgtataccta   4980

tgttaatgaa acaacagaag tacaaaaaag aatatcagat acaaaaatca atcgtgaaga   5040

aaatctgttc ttaatatatt tcattatgat tgaaaaacat aaaaactaac ataggaaagt   5100

gaatgatcag ttacttatga tatattttgt ttcctcttgt ggtttaataa agtgaagtgt   5160

gtgtgtgtgt gtgtgtgtgt atacctgggg gtgggcagtg ctctttttct aaaactaata   5220

tggcttatat atctgaatta tgcccttttt agtgtgtatt aggatgtggg ctggtttgct   5280

tttctaccac ctttgtaatt ttatgtatcc catctccttt gtgtgaattc atatattata   5340

gcaaaataca agagacatgg gactgtttgc aataccatat ggaaatcttt taataaatat   5400

atgtaaataa aataaaaaat atttgtctcc accttttccc caaaagcaac agcaagacat   5460

attttgttag atattttatt tttaatgttt tctataattt aaaaatgtat agcctgccaa   5520

atgttgtttt cataaccatg atattgtttt gaaaaaattt tatcttaaaa tactgaatgt   5580

tctgaccttt tatagatgtt tttgattttg ttttaaataa ttttaaatta tggagcttga   5640

cctagatttg ccaataaact ttctagccta aaaaaaaaaa aaaaaaa                 5687


<210>  910
<211>  1140
<212>  PRT
<213>  Homosapiens

<400>  910

Met Thr Thr Ala Val Glu Arg Lys Tyr Ile Asn Ile Arg Lys Arg Leu 
1               5                   10                  15      


Asp Gln Leu Gly Tyr Arg Gln Thr Leu Thr Val Glu Cys Leu Pro Leu 
            20                  25                  30          


Val Glu Lys Leu Phe Ser Asp Leu Val His Thr Thr Glu Ser Leu Arg 
        35                  40                  45              


Gln Ser Lys Leu Ser Ala Val Lys Ala Glu Lys Glu Ser Ala Asn Phe 
    50                  55                  60                  


Asp Phe Val Leu Glu Pro Tyr Lys Leu Glu Asn Ala Arg Leu Ser Arg 
65                  70                  75                  80  


Glu Asn Asn Glu Leu Tyr Leu Glu Leu Met Lys Leu Arg Glu His Ser 
                85                  90                  95      


Asp Gln His Val Lys Glu Leu Lys Thr Ser Leu Lys Lys Cys Ala Arg 
            100                 105                 110         


Glu Thr Ala Asp Leu Lys Phe Leu Asn Asn Gln Tyr Ala His Lys Leu 
        115                 120                 125             


Lys Leu Leu Glu Lys Glu Ser Lys Ala Lys Asn Glu Arg Ile Gln Gln 
    130                 135                 140                 


Leu Gln Glu Lys Asn Leu His Ala Val Val Gln Thr Pro Gly Gly Lys 
145                 150                 155                 160 


Lys Arg Ser Ile Ala Phe Arg Arg Gln Arg Met Gln Ile Asp Glu Pro 
                165                 170                 175     


Val Pro Pro Ser Glu Val Ser Ser Tyr Pro Val Pro Gln Pro Asp Asp 
            180                 185                 190         


Pro Tyr Ile Ala Asp Leu Leu Gln Val Ala Asp Asn Arg Ile Gln Glu 
        195                 200                 205             


Leu Gln Gln Glu Val His Gln Leu Gln Glu Lys Leu Ala Met Met Glu 
    210                 215                 220                 


Ser Gly Val Arg Asp Tyr Ser Lys Gln Ile Glu Leu Arg Glu Arg Glu 
225                 230                 235                 240 


Ile Glu Arg Leu Ser Val Ala Leu Asp Gly Gly Arg Ser Pro Asp Val 
                245                 250                 255     


Leu Ser Leu Glu Ser Arg Asn Lys Thr Asn Glu Lys Leu Ile Ala His 
            260                 265                 270         


Leu Asn Ile Gln Val Asp Phe Leu Gln Gln Ala Asn Lys Asp Leu Glu 
        275                 280                 285             


Lys Arg Ile Arg Glu Leu Met Glu Thr Lys Glu Thr Val Thr Ser Glu 
    290                 295                 300                 


Val Val Asn Leu Ser Asn Lys Asn Glu Lys Leu Cys Gln Glu Leu Thr 
305                 310                 315                 320 


Glu Ile Asp Gln Leu Ala Gln Gln Leu Glu Arg His Lys Glu Glu Val 
                325                 330                 335     


Leu Glu Thr Ala Asp Lys Glu Leu Gly Glu Ala Lys Lys Glu Ile Lys 
            340                 345                 350         


Arg Lys Leu Ser Glu Met Gln Asp Leu Glu Glu Thr Met Ala Lys Leu 
        355                 360                 365             


Gln Leu Glu Leu Asn Leu Cys Gln Lys Glu Lys Glu Arg Leu Ser Asp 
    370                 375                 380                 


Glu Leu Leu Val Lys Ser Asp Leu Glu Thr Val Val His Gln Leu Glu 
385                 390                 395                 400 


Gln Glu Lys Gln Arg Leu Ser Lys Lys Val Glu Ser Phe Ala Val Thr 
                405                 410                 415     


Glu Arg Gln Leu Thr Leu Glu Val Glu Arg Met Arg Leu Glu His Gly 
            420                 425                 430         


Ile Lys Arg Arg Asp Arg Ser Pro Ser Arg Leu Asp Thr Phe Leu Lys 
        435                 440                 445             


Gly Ile Glu Glu Glu Arg Asp Tyr Tyr Lys Lys Glu Leu Glu Arg Leu 
    450                 455                 460                 


Gln His Ile Ile Gln Arg Arg Ser Cys Ser Thr Ser Tyr Ser Ala Arg 
465                 470                 475                 480 


Glu Lys Ser Ser Ile Phe Arg Thr Pro Glu Lys Gly Asp Tyr Asn Ser 
                485                 490                 495     


Glu Ile His Gln Ile Thr Arg Glu Arg Asp Glu Leu Gln Arg Met Leu 
            500                 505                 510         


Glu Arg Phe Glu Lys Tyr Met Glu Asp Ile Gln Ser Asn Val Lys Leu 
        515                 520                 525             


Leu Thr Ala Glu Arg Asp Lys Leu Ser Val Leu Tyr Asn Glu Ala Gln 
    530                 535                 540                 


Glu Glu Leu Ser Ala Leu Arg Lys Glu Ser Thr Gln Thr Thr Ala Pro 
545                 550                 555                 560 


His Asn Ile Val Ser Leu Met Glu Lys Glu Lys Glu Leu Ala Leu Ser 
                565                 570                 575     


Asp Leu Arg Arg Ile Met Ala Glu Lys Glu Ala Leu Arg Glu Lys Leu 
            580                 585                 590         


Glu His Ile Glu Glu Val Ser Leu Phe Gly Lys Ser Glu Leu Glu Lys 
        595                 600                 605             


Thr Ile Glu His Leu Thr Cys Val Asn His Gln Leu Glu Ser Glu Lys 
    610                 615                 620                 


Tyr Glu Leu Lys Ser Lys Val Leu Ile Met Lys Glu Thr Ile Glu Ser 
625                 630                 635                 640 


Leu Glu Asn Lys Leu Lys Val Gln Ala Gln Lys Phe Ser His Val Ala 
                645                 650                 655     


Gly Asp Ser Ser His Gln Lys Thr Glu Val Asn Ser Leu Arg Ile Val 
            660                 665                 670         


Asn Glu Gln Leu Gln Arg Ser Val Asp Asp Tyr Gln His Arg Leu Ser 
        675                 680                 685             


Ile Lys Arg Gly Glu Leu Glu Ser Ala Gln Ala Gln Ile Lys Ile Leu 
    690                 695                 700                 


Glu Glu Lys Ile Asp Glu Leu Asn Leu Lys Met Thr Ser Gln Asp Glu 
705                 710                 715                 720 


Glu Ala His Val Met Lys Lys Thr Ile Gly Val Ile Asp Lys Glu Lys 
                725                 730                 735     


Asp Phe Leu Gln Glu Thr Val Asp Glu Lys Thr Glu Lys Ile Ala Asn 
            740                 745                 750         


Leu Gln Glu Asn Leu Ala Asn Lys Glu Lys Ala Val Ala Gln Met Lys 
        755                 760                 765             


Ile Met Ile Ser Glu Cys Glu Ser Ser Val Asn Gln Leu Lys Glu Thr 
    770                 775                 780                 


Leu Val Asn Arg Asp Arg Glu Ile Asn Ser Leu Arg Arg Gln Leu Asp 
785                 790                 795                 800 


Ala Ala His Lys Glu Leu Asp Glu Val Gly Arg Ser Arg Glu Ile Ala 
                805                 810                 815     


Phe Lys Glu Asn Arg Arg Leu Gln Asp Asp Leu Ala Thr Met Ala Arg 
            820                 825                 830         


Glu Asn Gln Glu Ile Ser Leu Glu Leu Glu Ala Ala Val Gln Glu Lys 
        835                 840                 845             


Glu Glu Met Lys Ser Arg Val His Lys Tyr Ile Thr Glu Val Ser Arg 
    850                 855                 860                 


Trp Glu Ser Leu Met Ala Ala Lys Glu Lys Glu Asn Gln Asp Leu Leu 
865                 870                 875                 880 


Asp Arg Phe Gln Met Leu His Asn Arg Ala Glu Asp Trp Glu Val Lys 
                885                 890                 895     


Ala His Gln Ala Glu Gly Glu Ser Ser Ser Val Arg Leu Glu Leu Leu 
            900                 905                 910         


Ser Ile Asp Thr Glu Arg Arg His Leu Arg Glu Arg Val Glu Leu Leu 
        915                 920                 925             


Glu Lys Glu Ile Gln Glu His Ile Asn Ala His His Ala Tyr Glu Ser 
    930                 935                 940                 


Gln Ile Ser Ser Met Ala Lys Ala Met Ser Arg Leu Glu Glu Glu Leu 
945                 950                 955                 960 


Arg His Gln Glu Asp Glu Lys Ala Thr Val Leu Asn Asp Leu Ser Ser 
                965                 970                 975     


Leu Arg Glu Leu Cys Ile Lys Leu Asp Ser Gly Lys Asp Ile Met Thr 
            980                 985                 990         


Gln Gln Leu Asn Ser Lys Asn Leu  Glu Phe Glu Arg Val  Val Val Glu 
        995                 1000                 1005             


Leu Glu  Asn Val Lys Ser Glu  Ser Asp Leu Leu Lys  Lys Gln Leu 
    1010                 1015                 1020             


Ser Asn  Glu Arg His Thr Val  Lys Asn Leu Glu Ser  Leu Leu Ala 
    1025                 1030                 1035             


Thr Asn  Arg Asp Lys Glu Phe  His Ser His Leu Thr  Ser His Glu 
    1040                 1045                 1050             


Lys Asp  Thr Glu Ile Gln Leu  Leu Lys Glu Lys Leu  Thr Leu Ser 
    1055                 1060                 1065             


Glu Ser  Lys Leu Thr Ser Gln  Ser Arg Glu Asn Thr  Met Leu Arg 
    1070                 1075                 1080             


Ala Lys  Val Ala Gln Leu Gln  Thr Asp Tyr Asp Ala  Leu Lys Arg 
    1085                 1090                 1095             


Gln Ile  Ser Thr Glu Arg Tyr  Glu Arg Glu Arg Ala  Ile Gln Glu 
    1100                 1105                 1110             


Met Arg  Arg His Gly Leu Ala  Thr Pro Pro Leu Ser  Ser Thr Leu 
    1115                 1120                 1125             


Arg Ser  Pro Ser His Ser Pro  Glu His Arg Asn Val  
    1130                 1135                 1140 


<210>  911
<211>  3349
<212>  DNA
<213>  Homosapiens

<400>  911
ggtggactga gccgctcggg acagcggcac cggaggaggc tcggagaaga tgcggggctc     60

ggggccccgg ggtgcgggac accggcggcc cccaagcggc ggcggcgaca cccccatcac    120

cccagcgtcc ctggccggct gctactctgc acctcgacgg gctcccctct ggacgtgcct    180

tctcctgtgc gccgcactcc ggaccctcct ggccagcccc agcaacgaag tgaatttatt    240

ggattcacgc actgtcatgg gggacctggg atggattgct tttccaaaaa atgggtggga    300

agagattggt gaagtggatg aaaattatgc ccctatccac acataccaag tatgcaaagt    360

gatggaacag aatcagaata actggctttt gaccagttgg atctccaatg aaggtgcttc    420

cagaatcttc atagaactca aatttaccct gcgggactgc aacagccttc ctggaggact    480

ggggacctgt aaggaaacct ttaatatgta ttactttgag tcagatgatc agaatgggag    540

aaacatcaag gaaaaccaat acatcaaaat tgataccatt gctgccgatg aaagctttac    600

agaacttgat cttggtgacc gtgttatgaa actgaataca gaggtcagag atgtaggacc    660

tctaagcaaa aagggatttt atcttgcttt tcaagatgtt ggtgcttgca ttgctctggt    720

ttctgtgcgt gtatactata aaaaatgccc ttctgtggta cgacacttgg ctgtcttccc    780

tgacaccatc actggagctg attcttccca attgctcgaa gtgtcaggct cctgtgtcaa    840

ccattctgtg accgatgaac ctcccaaaat gcactgcagc gccgaagggg agtggctggt    900

gcccatcggg aaatgcatgt gcaaggcagg atatgaagag aaaaatggca cctgtcaagt    960

gtgcagacct gggttcttca aagcctcacc tcacatccag agctgcggca aatgtccacc   1020

tcacagttat acccatgagg aagcttcaac ctcttgtgtc tgtgaaaagg attatttcag   1080

gagagagtct gatccaccca caatggcatg cacaagaccc ccctctgctc ctcggaatgc   1140

catctcaaat gttaatgaaa ctagtgtctt tctggaatgg attccgcctg ctgacactgg   1200

tggaaggaaa gacgtgtcat attatattgc atgcaagaag tgcaactccc atgcaggtgt   1260

gtgtgaggag tgtggcggtc atgtcaggta ccttccccgg caaagcggcc tgaaaaacac   1320

ctctgtcatg atggtggatc tactcgctca cacaaactat acctttgaga ttgaggcagt   1380

gaatggagtg tccgacttga gcccaggagc ccggcagtat gtgtctgtaa atgtaaccac   1440

aaatcaagca gctccatctc cagtcaccaa tgtgaaaaaa gggaaaattg caaaaaacag   1500

catctctttg tcttggcaag aaccagatcg tcccaatgga atcatcctag agtatgaaat   1560

caagtatttt gaaaaggacc aagagaccag ctacacgatt atcaaatcta aagagacaac   1620

tattactgca gagggcttga aaccagcttc agtttatgtc ttccaaattc gagcacgtac   1680

agcagcaggc tatggtgtct tcagtcgaag atttgagttt gaaaccaccc cagtgtttgc   1740

agcatccagc gatcaaagcc agattcctgt aattgctgtg tctgtgacag tgggagtcat   1800

tttgttggca gtggttatcg gcgtcctcct cagtggaagt tgctgcgaat gtggctgtgg   1860

gagggcttct tccctgtgcg ctgttgccca tccaagccta atatggcggt gtggctacag   1920

caaagcaaaa caagatccag aagaggaaaa gatgcatttt cataatgggc acattaaact   1980

gccaggagta agaacttaca ttgatccaca tacctatgag gatcccaatc aagctgtcca   2040

cgaatttgct aaggagatag aagcatcatg tatcaccatt gagagagtta ttggagcagg   2100

tgaatttggt gaagtttgta gtggacgttt gaaactacca ggaaaaagag aattacctgt   2160

ggctatcaaa acccttaaag taggctatac tgaaaagcaa cgcagagatt tcctaggtga   2220

agcaagtatc atgggacagt ttgatcatcc taacatcatc catttagaag gtgtggtgac   2280

caaaagtaaa ccagtgatga tcgtgacaga gtatatggag aatggctctt tagatacatt   2340

tttgaagaaa aacgatgggc agttcactgt gattcagctt gttggcatgc tgagaggtat   2400

ctctgcagga atgaagtacc tttctgacat gggctatgtg catagagatc ttgctgccag   2460

aaacatctta atcaacagta accttgtgtg caaagtgtct gactttggac tttcccgggt   2520

actggaagat gatcccgagg cagcctacac cacaagggga ggaaaaattc caatcagatg   2580

gactgcccca gaagcaatag ctttccgaaa gtttacttct gccagtgatg tctggagtta   2640

tggaatagta atgtgggaag ttgtgtctta tggagagaga ccctactggg agatgaccaa   2700

tcaagatgtg attaaagcgg tagaggaagg ctatcgtctg ccaagcccca tggattgtcc   2760

tgctgctctc tatcagttaa tgctggattg ctggcagaaa gagcgaaata gcaggcccaa   2820

gtttgatgaa atagtcaaca tgttggacaa gctgatacgt aacccaagta gtctgaagac   2880

gctggttaat gcatcctgca gagtatctaa tttattggca gaacatagcc cactaggatc   2940

tggggcctac agatcagtag gtgaatggct agaggcaatc aagatgggcc ggtatacaga   3000

gattttcatg gaaaatggat acagttcaat ggacgctgtg gctcaggtga ccttggagga   3060

tttgagacgg cttggagtga ctcttgtcgg tcaccagaag aagatcatga acagccttca   3120

agaaatgaag gtgcagctgg taaacggaat ggtgccattg taacttcatg taaatgtcgc   3180

ttcttcaagt gaatgattct gcactttgta aacagcactg agatttattt taacaaaaaa   3240

agggggaaaa gggaaaacag tgatttctaa accttagaaa acatttgcct cagccacaga   3300

atttgtaatc atggttttac tgaagtatcc agttcttagt ccttagtct               3349


<210>  912
<211>  1037
<212>  PRT
<213>  Homosapiens

<400>  912

Met Arg Gly Ser Gly Pro Arg Gly Ala Gly His Arg Arg Pro Pro Ser 
1               5                   10                  15      


Gly Gly Gly Asp Thr Pro Ile Thr Pro Ala Ser Leu Ala Gly Cys Tyr 
            20                  25                  30          


Ser Ala Pro Arg Arg Ala Pro Leu Trp Thr Cys Leu Leu Leu Cys Ala 
        35                  40                  45              


Ala Leu Arg Thr Leu Leu Ala Ser Pro Ser Asn Glu Val Asn Leu Leu 
    50                  55                  60                  


Asp Ser Arg Thr Val Met Gly Asp Leu Gly Trp Ile Ala Phe Pro Lys 
65                  70                  75                  80  


Asn Gly Trp Glu Glu Ile Gly Glu Val Asp Glu Asn Tyr Ala Pro Ile 
                85                  90                  95      


His Thr Tyr Gln Val Cys Lys Val Met Glu Gln Asn Gln Asn Asn Trp 
            100                 105                 110         


Leu Leu Thr Ser Trp Ile Ser Asn Glu Gly Ala Ser Arg Ile Phe Ile 
        115                 120                 125             


Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro Gly Gly Leu 
    130                 135                 140                 


Gly Thr Cys Lys Glu Thr Phe Asn Met Tyr Tyr Phe Glu Ser Asp Asp 
145                 150                 155                 160 


Gln Asn Gly Arg Asn Ile Lys Glu Asn Gln Tyr Ile Lys Ile Asp Thr 
                165                 170                 175     


Ile Ala Ala Asp Glu Ser Phe Thr Glu Leu Asp Leu Gly Asp Arg Val 
            180                 185                 190         


Met Lys Leu Asn Thr Glu Val Arg Asp Val Gly Pro Leu Ser Lys Lys 
        195                 200                 205             


Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile Ala Leu Val 
    210                 215                 220                 


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Ser Val Val Arg His Leu 
225                 230                 235                 240 


Ala Val Phe Pro Asp Thr Ile Thr Gly Ala Asp Ser Ser Gln Leu Leu 
                245                 250                 255     


Glu Val Ser Gly Ser Cys Val Asn His Ser Val Thr Asp Glu Pro Pro 
            260                 265                 270         


Lys Met His Cys Ser Ala Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
        275                 280                 285             


Cys Met Cys Lys Ala Gly Tyr Glu Glu Lys Asn Gly Thr Cys Gln Val 
    290                 295                 300                 


Cys Arg Pro Gly Phe Phe Lys Ala Ser Pro His Ile Gln Ser Cys Gly 
305                 310                 315                 320 


Lys Cys Pro Pro His Ser Tyr Thr His Glu Glu Ala Ser Thr Ser Cys 
                325                 330                 335     


Val Cys Glu Lys Asp Tyr Phe Arg Arg Glu Ser Asp Pro Pro Thr Met 
            340                 345                 350         


Ala Cys Thr Arg Pro Pro Ser Ala Pro Arg Asn Ala Ile Ser Asn Val 
        355                 360                 365             


Asn Glu Thr Ser Val Phe Leu Glu Trp Ile Pro Pro Ala Asp Thr Gly 
    370                 375                 380                 


Gly Arg Lys Asp Val Ser Tyr Tyr Ile Ala Cys Lys Lys Cys Asn Ser 
385                 390                 395                 400 


His Ala Gly Val Cys Glu Glu Cys Gly Gly His Val Arg Tyr Leu Pro 
                405                 410                 415     


Arg Gln Ser Gly Leu Lys Asn Thr Ser Val Met Met Val Asp Leu Leu 
            420                 425                 430         


Ala His Thr Asn Tyr Thr Phe Glu Ile Glu Ala Val Asn Gly Val Ser 
        435                 440                 445             


Asp Leu Ser Pro Gly Ala Arg Gln Tyr Val Ser Val Asn Val Thr Thr 
    450                 455                 460                 


Asn Gln Ala Ala Pro Ser Pro Val Thr Asn Val Lys Lys Gly Lys Ile 
465                 470                 475                 480 


Ala Lys Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Asp Arg Pro Asn 
                485                 490                 495     


Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Phe Glu Lys Asp Gln Glu 
            500                 505                 510         


Thr Ser Tyr Thr Ile Ile Lys Ser Lys Glu Thr Thr Ile Thr Ala Glu 
        515                 520                 525             


Gly Leu Lys Pro Ala Ser Val Tyr Val Phe Gln Ile Arg Ala Arg Thr 
    530                 535                 540                 


Ala Ala Gly Tyr Gly Val Phe Ser Arg Arg Phe Glu Phe Glu Thr Thr 
545                 550                 555                 560 


Pro Val Phe Ala Ala Ser Ser Asp Gln Ser Gln Ile Pro Val Ile Ala 
                565                 570                 575     


Val Ser Val Thr Val Gly Val Ile Leu Leu Ala Val Val Ile Gly Val 
            580                 585                 590         


Leu Leu Ser Gly Ser Cys Cys Glu Cys Gly Cys Gly Arg Ala Ser Ser 
        595                 600                 605             


Leu Cys Ala Val Ala His Pro Ser Leu Ile Trp Arg Cys Gly Tyr Ser 
    610                 615                 620                 


Lys Ala Lys Gln Asp Pro Glu Glu Glu Lys Met His Phe His Asn Gly 
625                 630                 635                 640 


His Ile Lys Leu Pro Gly Val Arg Thr Tyr Ile Asp Pro His Thr Tyr 
                645                 650                 655     


Glu Asp Pro Asn Gln Ala Val His Glu Phe Ala Lys Glu Ile Glu Ala 
            660                 665                 670         


Ser Cys Ile Thr Ile Glu Arg Val Ile Gly Ala Gly Glu Phe Gly Glu 
        675                 680                 685             


Val Cys Ser Gly Arg Leu Lys Leu Pro Gly Lys Arg Glu Leu Pro Val 
    690                 695                 700                 


Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp 
705                 710                 715                 720 


Phe Leu Gly Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro Asn Ile 
                725                 730                 735     


Ile His Leu Glu Gly Val Val Thr Lys Ser Lys Pro Val Met Ile Val 
            740                 745                 750         


Thr Glu Tyr Met Glu Asn Gly Ser Leu Asp Thr Phe Leu Lys Lys Asn 
        755                 760                 765             


Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile 
    770                 775                 780                 


Ser Ala Gly Met Lys Tyr Leu Ser Asp Met Gly Tyr Val His Arg Asp 
785                 790                 795                 800 


Leu Ala Ala Arg Asn Ile Leu Ile Asn Ser Asn Leu Val Cys Lys Val 
                805                 810                 815     


Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro Glu Ala Ala 
            820                 825                 830         


Tyr Thr Thr Arg Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu 
        835                 840                 845             


Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr 
    850                 855                 860                 


Gly Ile Val Met Trp Glu Val Val Ser Tyr Gly Glu Arg Pro Tyr Trp 
865                 870                 875                 880 


Glu Met Thr Asn Gln Asp Val Ile Lys Ala Val Glu Glu Gly Tyr Arg 
                885                 890                 895     


Leu Pro Ser Pro Met Asp Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu 
            900                 905                 910         


Asp Cys Trp Gln Lys Glu Arg Asn Ser Arg Pro Lys Phe Asp Glu Ile 
        915                 920                 925             


Val Asn Met Leu Asp Lys Leu Ile Arg Asn Pro Ser Ser Leu Lys Thr 
    930                 935                 940                 


Leu Val Asn Ala Ser Cys Arg Val Ser Asn Leu Leu Ala Glu His Ser 
945                 950                 955                 960 


Pro Leu Gly Ser Gly Ala Tyr Arg Ser Val Gly Glu Trp Leu Glu Ala 
                965                 970                 975     


Ile Lys Met Gly Arg Tyr Thr Glu Ile Phe Met Glu Asn Gly Tyr Ser 
            980                 985                 990         


Ser Met Asp Ala Val Ala Gln Val  Thr Leu Glu Asp Leu  Arg Arg Leu 
        995                 1000                 1005             


Gly Val  Thr Leu Val Gly His  Gln Lys Lys Ile Met  Asn Ser Leu 
    1010                 1015                 1020             


Gln Glu  Met Lys Val Gln Leu  Val Asn Gly Met Val  Pro Leu 
    1025                 1030                 1035         


<210>  913
<211>  3283
<212>  DNA
<213>  Homosapiens

<400>  913
ggtggactga gccgctcggg acagcggcac cggaggaggc tcggagaaga tgcggggctc     60

ggggccccgg ggtgcgggac accggcggcc cccaagcggc ggcggcgaca cccccatcac    120

cccagcgtcc ctggccggct gctactctgc acctcgacgg gctcccctct ggacgtgcct    180

tctcctgtgc gccgcactcc ggaccctcct ggccagcccc agcaacgaag tgaatttatt    240

ggattcacgc actgtcatgg gggacctggg atggattgct tttccaaaaa atgggtggga    300

agagattggt gaagtggatg aaaattatgc ccctatccac acataccaag tatgcaaagt    360

gatggaacag aatcagaata actggctttt gaccagttgg atctccaatg aaggtgcttc    420

cagaatcttc atagaactca aatttaccct gcgggactgc aacagccttc ctggaggact    480

ggggacctgt aaggaaacct ttaatatgta ttactttgag tcagatgatc agaatgggag    540

aaacatcaag gaaaaccaat acatcaaaat tgataccatt gctgccgatg aaagctttac    600

agaacttgat cttggtgacc gtgttatgaa actgaataca gaggtcagag atgtaggacc    660

tctaagcaaa aagggatttt atcttgcttt tcaagatgtt ggtgcttgca ttgctctggt    720

ttctgtgcgt gtatactata aagaatgccc ttctgtggta cgacacttgg ctgtcttccc    780

tgacaccatc actggagctg attcttccca attgctcgaa gtgtcaggct cctgtgtcaa    840

ccattctgtg accgatgaac ctcccaaaat gcactgcagc gccgaagggg agtggctggt    900

gcccatcggg aaatgcatgt gcaaggcagg atatgaagag aaaaatggca cctgtcaagt    960

gtgcagacct gggttcttca aagcctcacc tcacatccag agctgcggca aatgtccacc   1020

tcacagttat acccatgagg aagcttcaac ctcttgtgtc tgtgaaaagg attatttcag   1080

gagagagtct gatccaccca caatggcatg cacaagaccc ccctctgctc ctcggaatgc   1140

catctcaaat gttaatgaaa ctagtgtctt tctggaatgg attccgcctg ctgacactgg   1200

tggaaggaaa gacgtgtcat attatattgc atgcaagaag tgcaactccc atgcaggtgt   1260

gtgtgaggag tgtggcggtc atgtcaggta ccttccccgg caaagcggcc tgaaaaacac   1320

ctctgtcatg atggtggatc tactcgctca cacaaactat acctttgaga ttgaggcagt   1380

gaatggagtg tccgacttga gcccaggagc ccggcagtat gtgtctgtaa atgtaaccac   1440

aaatcaagca gctccatctc cagtcaccaa tgtgaaaaaa gggaaaattg caaaaaacag   1500

catctctttg tcttggcaag aaccagatcg tcccaatgga atcatcctag agtatgaaat   1560

caagtatttt gaaaaggacc aagagaccag ctacacgatt atcaaatcta aagagacaac   1620

tattactgca gagggcttga aaccagcttc agtttatgtc ttccaaattc gagcacgtac   1680

agcagcaggc tatggtgtct tcagtcgaag atttgagttt gaaaccaccc cagtgtttgc   1740

agcatccagc gatcaaagcc agattcctgt aattgctgtg tctgtgacag tgggagtcat   1800

tttgttggca gtggttatcg gcgtcctcct cagtggaagg cggtgtggct acagcaaagc   1860

aaaacaagat ccagaagagg aaaagatgca ttttcataat gggcacatta aactgccagg   1920

agtaagaact tacattgatc cacataccta tgaggatccc aatcaagctg tccacgaatt   1980

tgctaaggag atagaagcat catgtatcac cattgagaga gttattggag caggtgaatt   2040

tggtgaagtt tgtagtggac gtttgaaact accaggaaaa agagaattac ctgtggctat   2100

caaaaccctt aaagtaggct atactgaaaa gcaacgcaga gatttcctag gtgaagcaag   2160

tatcatggga cagtttgatc atcctaacat catccattta gaaggtgtgg tgaccaaaag   2220

taaaccagtg atgatcgtga cagagtatat ggagaatggc tctttagata catttttgaa   2280

gaaaaacgat gggcagttca ctgtgattca gcttgttggc atgctgagag gtatctctgc   2340

aggaatgaag tacctttctg acatgggcta tgtgcataga gatcttgctg ccagaaacat   2400

cttaatcaac agtaaccttg tgtgcaaagt gtctgacttt ggactttccc gggtactgga   2460

agatgatccc gaggcagcct acaccacaag gggaggaaaa attccaatca gatggactgc   2520

cccagaagca atagctttcc gaaagtttac ttctgccagt gatgtctgga gttatggaat   2580

agtaatgtgg gaagttgtgt cttatggaga gagaccctac tgggagatga ccaatcaaga   2640

tgtgattaaa gcggtagagg aaggctatcg tctgccaagc cccatggatt gtcctgctgc   2700

tctctatcag ttaatgctgg attgctggca gaaagagcga aatagcaggc ccaagtttga   2760

tgaaatagtc aacatgttgg acaagctgat acgtaaccca agtagtctga agacgctggt   2820

taatgcatcc tgcagagtat ctaatttatt ggcagaacat agcccactag gatctggggc   2880

ctacagatca gtaggtgaat ggctagaggc aatcaagatg ggccggtata cagagatttt   2940

catggaaaat ggatacagtt caatggacgc tgtggctcag gtgaccttgg aggatttgag   3000

acggcttgga gtgactcttg tcggtcacca gaagaagatc atgaacagcc ttcaagaaat   3060

gaaggtgcag ctggtaaacg gaatggtgcc attgtaactt catgtaaatg tcgcttcttc   3120

aagtgaatga ttctgcactt tgtaaacagc actgagattt attttaacaa aaaaaggggg   3180

aaaagggaaa acagtgattt ctaaacctta gaaaacattt gcctcagcca cagaatttgt   3240

aatcatggtt ttactgaagt atccagttct tagtccttag tct                     3283


<210>  914
<211>  1015
<212>  PRT
<213>  Homosapiens

<400>  914

Met Arg Gly Ser Gly Pro Arg Gly Ala Gly His Arg Arg Pro Pro Ser 
1               5                   10                  15      


Gly Gly Gly Asp Thr Pro Ile Thr Pro Ala Ser Leu Ala Gly Cys Tyr 
            20                  25                  30          


Ser Ala Pro Arg Arg Ala Pro Leu Trp Thr Cys Leu Leu Leu Cys Ala 
        35                  40                  45              


Ala Leu Arg Thr Leu Leu Ala Ser Pro Ser Asn Glu Val Asn Leu Leu 
    50                  55                  60                  


Asp Ser Arg Thr Val Met Gly Asp Leu Gly Trp Ile Ala Phe Pro Lys 
65                  70                  75                  80  


Asn Gly Trp Glu Glu Ile Gly Glu Val Asp Glu Asn Tyr Ala Pro Ile 
                85                  90                  95      


His Thr Tyr Gln Val Cys Lys Val Met Glu Gln Asn Gln Asn Asn Trp 
            100                 105                 110         


Leu Leu Thr Ser Trp Ile Ser Asn Glu Gly Ala Ser Arg Ile Phe Ile 
        115                 120                 125             


Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro Gly Gly Leu 
    130                 135                 140                 


Gly Thr Cys Lys Glu Thr Phe Asn Met Tyr Tyr Phe Glu Ser Asp Asp 
145                 150                 155                 160 


Gln Asn Gly Arg Asn Ile Lys Glu Asn Gln Tyr Ile Lys Ile Asp Thr 
                165                 170                 175     


Ile Ala Ala Asp Glu Ser Phe Thr Glu Leu Asp Leu Gly Asp Arg Val 
            180                 185                 190         


Met Lys Leu Asn Thr Glu Val Arg Asp Val Gly Pro Leu Ser Lys Lys 
        195                 200                 205             


Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile Ala Leu Val 
    210                 215                 220                 


Ser Val Arg Val Tyr Tyr Lys Glu Cys Pro Ser Val Val Arg His Leu 
225                 230                 235                 240 


Ala Val Phe Pro Asp Thr Ile Thr Gly Ala Asp Ser Ser Gln Leu Leu 
                245                 250                 255     


Glu Val Ser Gly Ser Cys Val Asn His Ser Val Thr Asp Glu Pro Pro 
            260                 265                 270         


Lys Met His Cys Ser Ala Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
        275                 280                 285             


Cys Met Cys Lys Ala Gly Tyr Glu Glu Lys Asn Gly Thr Cys Gln Val 
    290                 295                 300                 


Cys Arg Pro Gly Phe Phe Lys Ala Ser Pro His Ile Gln Ser Cys Gly 
305                 310                 315                 320 


Lys Cys Pro Pro His Ser Tyr Thr His Glu Glu Ala Ser Thr Ser Cys 
                325                 330                 335     


Val Cys Glu Lys Asp Tyr Phe Arg Arg Glu Ser Asp Pro Pro Thr Met 
            340                 345                 350         


Ala Cys Thr Arg Pro Pro Ser Ala Pro Arg Asn Ala Ile Ser Asn Val 
        355                 360                 365             


Asn Glu Thr Ser Val Phe Leu Glu Trp Ile Pro Pro Ala Asp Thr Gly 
    370                 375                 380                 


Gly Arg Lys Asp Val Ser Tyr Tyr Ile Ala Cys Lys Lys Cys Asn Ser 
385                 390                 395                 400 


His Ala Gly Val Cys Glu Glu Cys Gly Gly His Val Arg Tyr Leu Pro 
                405                 410                 415     


Arg Gln Ser Gly Leu Lys Asn Thr Ser Val Met Met Val Asp Leu Leu 
            420                 425                 430         


Ala His Thr Asn Tyr Thr Phe Glu Ile Glu Ala Val Asn Gly Val Ser 
        435                 440                 445             


Asp Leu Ser Pro Gly Ala Arg Gln Tyr Val Ser Val Asn Val Thr Thr 
    450                 455                 460                 


Asn Gln Ala Ala Pro Ser Pro Val Thr Asn Val Lys Lys Gly Lys Ile 
465                 470                 475                 480 


Ala Lys Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Asp Arg Pro Asn 
                485                 490                 495     


Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Phe Glu Lys Asp Gln Glu 
            500                 505                 510         


Thr Ser Tyr Thr Ile Ile Lys Ser Lys Glu Thr Thr Ile Thr Ala Glu 
        515                 520                 525             


Gly Leu Lys Pro Ala Ser Val Tyr Val Phe Gln Ile Arg Ala Arg Thr 
    530                 535                 540                 


Ala Ala Gly Tyr Gly Val Phe Ser Arg Arg Phe Glu Phe Glu Thr Thr 
545                 550                 555                 560 


Pro Val Phe Ala Ala Ser Ser Asp Gln Ser Gln Ile Pro Val Ile Ala 
                565                 570                 575     


Val Ser Val Thr Val Gly Val Ile Leu Leu Ala Val Val Ile Gly Val 
            580                 585                 590         


Leu Leu Ser Gly Arg Arg Cys Gly Tyr Ser Lys Ala Lys Gln Asp Pro 
        595                 600                 605             


Glu Glu Glu Lys Met His Phe His Asn Gly His Ile Lys Leu Pro Gly 
    610                 615                 620                 


Val Arg Thr Tyr Ile Asp Pro His Thr Tyr Glu Asp Pro Asn Gln Ala 
625                 630                 635                 640 


Val His Glu Phe Ala Lys Glu Ile Glu Ala Ser Cys Ile Thr Ile Glu 
                645                 650                 655     


Arg Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
            660                 665                 670         


Lys Leu Pro Gly Lys Arg Glu Leu Pro Val Ala Ile Lys Thr Leu Lys 
        675                 680                 685             


Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser 
    690                 695                 700                 


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val 
705                 710                 715                 720 


Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn 
                725                 730                 735     


Gly Ser Leu Asp Thr Phe Leu Lys Lys Asn Asp Gly Gln Phe Thr Val 
            740                 745                 750         


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ser Ala Gly Met Lys Tyr 
        755                 760                 765             


Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
    770                 775                 780                 


Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
785                 790                 795                 800 


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
                805                 810                 815     


Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Lys 
            820                 825                 830         


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
        835                 840                 845             


Val Val Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Thr Asn Gln Asp 
    850                 855                 860                 


Val Ile Lys Ala Val Glu Glu Gly Tyr Arg Leu Pro Ser Pro Met Asp 
865                 870                 875                 880 


Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Glu 
                885                 890                 895     


Arg Asn Ser Arg Pro Lys Phe Asp Glu Ile Val Asn Met Leu Asp Lys 
            900                 905                 910         


Leu Ile Arg Asn Pro Ser Ser Leu Lys Thr Leu Val Asn Ala Ser Cys 
        915                 920                 925             


Arg Val Ser Asn Leu Leu Ala Glu His Ser Pro Leu Gly Ser Gly Ala 
    930                 935                 940                 


Tyr Arg Ser Val Gly Glu Trp Leu Glu Ala Ile Lys Met Gly Arg Tyr 
945                 950                 955                 960 


Thr Glu Ile Phe Met Glu Asn Gly Tyr Ser Ser Met Asp Ala Val Ala 
                965                 970                 975     


Gln Val Thr Leu Glu Asp Leu Arg Arg Leu Gly Val Thr Leu Val Gly 
            980                 985                 990         


His Gln Lys Lys Ile Met Asn Ser  Leu Gln Glu Met Lys  Val Gln Leu 
        995                 1000                 1005             


Val Asn  Gly Met Val Pro Leu  
    1010                 1015 


<210>  915
<211>  958
<212>  DNA
<213>  Homosapiens

<400>  915
ctgccctcct gcttccgttg ctagggacgc ttcggccgag gataccgcaa tggatcagga     60

agaggggctg aaggccttgg acaatattgt cactcaattc aacgcctatg aagatttcct    120

ggactcgcag atcactactg tggacttgta ctacctggag gatgaaaccc tggcccgcca    180

gttggtggag ctaggctacc gagggactgg agagagagtg aaaagggaag attttgaagc    240

aaggaaagcg gctatagaga ttgcaagact ggctgaaaga gctcagcaaa agacgctaac    300

aagtgctggt aaagacctac aagataattt tctgacggcc ctggcaatga gagaagaaga    360

caatcgcagt ggaaaactga gttccgtgat ctttattcgt gacagaaatt ctcatgggca    420

agagatatca ggatacatcg actatgccca caggctaaag acggaagatt ttgaagtcta    480

ctttactgga aaaaaaagac ttcttccaag gcctacagat ataagctttt acaactggga    540

cgctgatatt gctgttagta attcaagtcc caactatcaa gtgattgccg ataatccaga    600

aggcttactt ttcagataca aaagagacag aaaaattctt aatgtggacc caaaggcgca    660

gccaggtgac aactctacta gaatcactat cctgacagaa ctctacatac aagctgtcat    720

ttttgaccac atttccagaa ggaagactta agtaccaaca tgttaatttc ctaataattt    780

gctaaattta aataaattcc gtagacagag caaattagaa taataaatga gccctgtagc    840

tggaaggcaa attagaacaa taaagttaat aaagaagtta gaaagaaaaa aaaaaaaaaa    900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa      958


<210>  916
<211>  233
<212>  PRT
<213>  Homosapiens

<400>  916

Met Asp Gln Glu Glu Gly Leu Lys Ala Leu Asp Asn Ile Val Thr Gln 
1               5                   10                  15      


Phe Asn Ala Tyr Glu Asp Phe Leu Asp Ser Gln Ile Thr Thr Val Asp 
            20                  25                  30          


Leu Tyr Tyr Leu Glu Asp Glu Thr Leu Ala Arg Gln Leu Val Glu Leu 
        35                  40                  45              


Gly Tyr Arg Gly Thr Gly Glu Arg Val Lys Arg Glu Asp Phe Glu Ala 
    50                  55                  60                  


Arg Lys Ala Ala Ile Glu Ile Ala Arg Leu Ala Glu Arg Ala Gln Gln 
65                  70                  75                  80  


Lys Thr Leu Thr Ser Ala Gly Lys Asp Leu Gln Asp Asn Phe Leu Thr 
                85                  90                  95      


Ala Leu Ala Met Arg Glu Glu Asp Asn Arg Ser Gly Lys Leu Ser Ser 
            100                 105                 110         


Val Ile Phe Ile Arg Asp Arg Asn Ser His Gly Gln Glu Ile Ser Gly 
        115                 120                 125             


Tyr Ile Asp Tyr Ala His Arg Leu Lys Thr Glu Asp Phe Glu Val Tyr 
    130                 135                 140                 


Phe Thr Gly Lys Lys Arg Leu Leu Pro Arg Pro Thr Asp Ile Ser Phe 
145                 150                 155                 160 


Tyr Asn Trp Asp Ala Asp Ile Ala Val Ser Asn Ser Ser Pro Asn Tyr 
                165                 170                 175     


Gln Val Ile Ala Asp Asn Pro Glu Gly Leu Leu Phe Arg Tyr Lys Arg 
            180                 185                 190         


Asp Arg Lys Ile Leu Asn Val Asp Pro Lys Ala Gln Pro Gly Asp Asn 
        195                 200                 205             


Ser Thr Arg Ile Thr Ile Leu Thr Glu Leu Tyr Ile Gln Ala Val Ile 
    210                 215                 220                 


Phe Asp His Ile Ser Arg Arg Lys Thr 
225                 230             


<210>  917
<211>  1774
<212>  DNA
<213>  Homosapiens

<400>  917
agatcttgaa aacacccggg ccacacacgc cgcgacctac agctctttct cagcgttgga     60

gtggagacgg cgcccgcagc gccctgcgcg ggtgaggtcc gcgcagctgc tggggaagag    120

cccacctgtc aggctgcgct gggtcagcgc agcaagtggg gctggccgct atctcgctgc    180

acccggccgc gtcccgggct ccgtgcgccc tcgccccagc tggtttggag ttcaaccctc    240

ggctccgccg ccggctcctt gcgccttcgg agtgtcccgc agcgacgccg ggagccgacg    300

cgccgcgcgg gtacctagcc atggctgggg cgagcaggct gctctttctg tggctgggct    360

gcttctgcgt gagcctggcg cagggagaga gaccgaagcc acctttcccg gagctccgca    420

aagctgtgcc aggtgaccgc acggcaggtg gtggcccgga ctccgagctg cagccgcaag    480

acaaggtctc tgaacacatg ctgcggctct atgacaggta cagcacggtc caggcggccc    540

ggacaccggg ctccctggag ggaggctcgc agccctggcg ccctcggctc ctgcgcgaag    600

gcaacacggt tcgcagcttt cgggcggcag cagcagaaac tcttgaaaga aaaggactgt    660

atatcttcaa tctgacatcg ctaaccaagt ctgaaaacat tttgtctgcc acactgtatt    720

tctgtattgg agagctagga aacatcagcc tgagttgtcc agtgtctgga ggatgctccc    780

atcatgctca gaggaaacac attcagattg atctttctgc atggaccctc aaattcagca    840

gaaaccaaag tcaactcctt ggccatctgt cagtggatat ggccaaatct catcgagata    900

ttatgtcctg gctgtctaaa gatatcactc aattcttgag gaaggccaaa gaaaatgaag    960

agttcctcat aggatttaac attacgtcca agggacgcca gctgccaaag aggaggttac   1020

cttttccaga gccttatatc ttggtatatg ccaatgatgc cgccatttct gagccagaaa   1080

gtgtggtatc aagcttacag ggacaccgga attttcccac tggaactgtt cccaaatggg   1140

atagccacat cagagctgcc ctttccattg agcggaggaa gaagcgctct actggggtct   1200

tgctgcctct gcagaacaac gagcttcctg gggcagaata ccagtataaa aaggatgagg   1260

tgtgggagga gagaaagcct tacaagaccc ttcaggctca ggcccctgaa aagagtaaga   1320

ataaaaagaa acagagaaag gggcctcatc ggaagagcca gacgctccaa tttgatgagc   1380

agaccctgaa aaaggcaagg agaaagcagt ggattgaacc tcggaattgc gccaggagat   1440

acctcaaggt agactttgca gatattggct ggagtgaatg gattatctcc cccaagtcct   1500

ttgatgccta ttattgctct ggagcatgcc agttccccat gccaaagtct ttgaagccat   1560

caaatcatgc taccatccag agtatagtga gagctgtggg ggtcgttcct gggattcctg   1620

agccttgctg tgtaccagaa aagatgtcct cactcagtat tttattcttt gatgaaaata   1680

agaatgtagt gcttaaagta taccctaaca tgacagtaga gtcttgcgct tgcagataac   1740

ctggcaaaga actcatttga atgcttaatt caat                               1774


<210>  918
<211>  472
<212>  PRT
<213>  Homosapiens

<400>  918

Met Ala Gly Ala Ser Arg Leu Leu Phe Leu Trp Leu Gly Cys Phe Cys 
1               5                   10                  15      


Val Ser Leu Ala Gln Gly Glu Arg Pro Lys Pro Pro Phe Pro Glu Leu 
            20                  25                  30          


Arg Lys Ala Val Pro Gly Asp Arg Thr Ala Gly Gly Gly Pro Asp Ser 
        35                  40                  45              


Glu Leu Gln Pro Gln Asp Lys Val Ser Glu His Met Leu Arg Leu Tyr 
    50                  55                  60                  


Asp Arg Tyr Ser Thr Val Gln Ala Ala Arg Thr Pro Gly Ser Leu Glu 
65                  70                  75                  80  


Gly Gly Ser Gln Pro Trp Arg Pro Arg Leu Leu Arg Glu Gly Asn Thr 
                85                  90                  95      


Val Arg Ser Phe Arg Ala Ala Ala Ala Glu Thr Leu Glu Arg Lys Gly 
            100                 105                 110         


Leu Tyr Ile Phe Asn Leu Thr Ser Leu Thr Lys Ser Glu Asn Ile Leu 
        115                 120                 125             


Ser Ala Thr Leu Tyr Phe Cys Ile Gly Glu Leu Gly Asn Ile Ser Leu 
    130                 135                 140                 


Ser Cys Pro Val Ser Gly Gly Cys Ser His His Ala Gln Arg Lys His 
145                 150                 155                 160 


Ile Gln Ile Asp Leu Ser Ala Trp Thr Leu Lys Phe Ser Arg Asn Gln 
                165                 170                 175     


Ser Gln Leu Leu Gly His Leu Ser Val Asp Met Ala Lys Ser His Arg 
            180                 185                 190         


Asp Ile Met Ser Trp Leu Ser Lys Asp Ile Thr Gln Phe Leu Arg Lys 
        195                 200                 205             


Ala Lys Glu Asn Glu Glu Phe Leu Ile Gly Phe Asn Ile Thr Ser Lys 
    210                 215                 220                 


Gly Arg Gln Leu Pro Lys Arg Arg Leu Pro Phe Pro Glu Pro Tyr Ile 
225                 230                 235                 240 


Leu Val Tyr Ala Asn Asp Ala Ala Ile Ser Glu Pro Glu Ser Val Val 
                245                 250                 255     


Ser Ser Leu Gln Gly His Arg Asn Phe Pro Thr Gly Thr Val Pro Lys 
            260                 265                 270         


Trp Asp Ser His Ile Arg Ala Ala Leu Ser Ile Glu Arg Arg Lys Lys 
        275                 280                 285             


Arg Ser Thr Gly Val Leu Leu Pro Leu Gln Asn Asn Glu Leu Pro Gly 
    290                 295                 300                 


Ala Glu Tyr Gln Tyr Lys Lys Asp Glu Val Trp Glu Glu Arg Lys Pro 
305                 310                 315                 320 


Tyr Lys Thr Leu Gln Ala Gln Ala Pro Glu Lys Ser Lys Asn Lys Lys 
                325                 330                 335     


Lys Gln Arg Lys Gly Pro His Arg Lys Ser Gln Thr Leu Gln Phe Asp 
            340                 345                 350         


Glu Gln Thr Leu Lys Lys Ala Arg Arg Lys Gln Trp Ile Glu Pro Arg 
        355                 360                 365             


Asn Cys Ala Arg Arg Tyr Leu Lys Val Asp Phe Ala Asp Ile Gly Trp 
    370                 375                 380                 


Ser Glu Trp Ile Ile Ser Pro Lys Ser Phe Asp Ala Tyr Tyr Cys Ser 
385                 390                 395                 400 


Gly Ala Cys Gln Phe Pro Met Pro Lys Ser Leu Lys Pro Ser Asn His 
                405                 410                 415     


Ala Thr Ile Gln Ser Ile Val Arg Ala Val Gly Val Val Pro Gly Ile 
            420                 425                 430         


Pro Glu Pro Cys Cys Val Pro Glu Lys Met Ser Ser Leu Ser Ile Leu 
        435                 440                 445             


Phe Phe Asp Glu Asn Lys Asn Val Val Leu Lys Val Tyr Pro Asn Met 
    450                 455                 460                 


Thr Val Glu Ser Cys Ala Cys Arg 
465                 470         


<210>  919
<211>  3328
<212>  DNA
<213>  Homosapiens

<400>  919
ggtccctgag caaaatggga aatggttcag tgaaacctaa acattctaag cacccagatg     60

gacactctgg gaacctcacc actgatgctc tgcggaacaa ggtgacagag ctggagagag    120

agttgaggag gaaggatgct gagatccagg agcgggagta ccatttgaag gagctgcggg    180

agcagctgtc gaagcagact gtggccattg ctgaactcac agaggagctc cagaacaagt    240

gcatccagct gaacaagctg caggatgtgg tgcatatgca gggaggaagc ccgcttcagg    300

cctctccaga taaagtgcct cttgaggtcc accggaagac ctctggattg gtctctctcc    360

atagcaggag gggagcaaag gctggcgtgt ctgctgagcc aacaacccgg acctatgacc    420

tgaacaaacc ccctgaattt tcctttgaga aagcaagagt cagaaaagac tccagtgaga    480

agaagctcat tacagatgcc cttaataaaa atcagtttct gaaaagactg gatcctcagc    540

agatcaaaga catggtggaa tgcatgtatg ggagaaacta tcagcaaggg agttacatta    600

ttaagcaagg agaaccagga aaccatatct ttgtgctggc agagggtcga ctagaggtgt    660

tccaagggga gaaattgctg tcctccatcc ctatgtggac cacatttggg gagcttgcca    720

ttttatacaa ttgtacaagg actgcctctg tgaaagctat taccaatgtt aaaacatggg    780

cactagatcg agaggtattc cagaatataa tgaggaggac agcccaagct agagatgaac    840

aatacagaaa cttcctcaga agtgtatcct tgctgaagaa tttacctgaa gataaattaa    900

ccaagatcat tgactgcttg gaagtggaat actatgacaa aggagattac atcattagag    960

agggcgagga aggaagtacc tttttcattt tggcaaaagg aaaggtaaaa gtaacacaga   1020

gcacagaagg ccatgatcaa ccacagctga taaaaacact gcagaaagga gaatactttg   1080

gagaaaaagc tcttatcagt gatgatgtca ggtcagctaa cattattgct gaagaaaatg   1140

atgttgcatg cctggttata gatcgagaaa cattcaacca aactgtcggt acatttgaag   1200

agctgcaaaa ataccttgaa ggatatgtgg caaacctgaa ccgtgatgat gaaaaaagac   1260

atgcgaagcg gtccatgtct aactggaagc tgtccaaagc actctctctg gaaatgattc   1320

agctgaagga gaaggtggcc agattttcct catcatcccc attccagaac cttgagatta   1380

ttgcaacact gggcgttggt gggttcggaa gagttgagct tgttaaagta aaaaatgaga   1440

atgttgcttt tgctatgaag tgtataagga agaagcacat agttgacacc aagcagcagg   1500

agcatgtcta ctcagagaag aggatcctag aggagctgtg ctctccattc attgtgaaat   1560

tatatcgtac tttcaaggac aataagtatg tatacatgct tctggaggcc tgcttaggtg   1620

gggagctctg gagtatatta agggacagag gcagctttga tgaacccacc tccaaattct   1680

gcgttgcttg tgtgacagaa gcatttgatt acctgcatcg actaggtatt atctacagag   1740

acttgaaacc agaaaactta attctagatg ctgagggtta ccttaaattg gttgactttg   1800

gatttgcgaa gaaaataggg tctggacaga aaacatggac attctgtggg actccagaat   1860

atgtagctcc tgaagtcatt ctcaacaagg gacatgactt cagtgtggat ttctggtcac   1920

tgggaattct agtgtatgag ctcctaacgg gcaacccacc cttttctggg gttgaccaaa   1980

tgatgaccta caatttgatt ctcaaaggaa ttgaaaaaat ggattttccc aggaagataa   2040

cacgacgacc tgaggatttg attcggaggc tttgcaggca aaatccaaca gaaaggctgg   2100

gaaatctgaa gaatggaata aatgacatta agaaacacag gtggttaaat ggttttaatt   2160

gggagggact gaaagcacgg agccttccat cacctttgca aagagagctc aagggaccca   2220

tagatcacag ctactttgac aaatatcctc ctgaaaaggg aatgcctcca gatgagctat   2280

caggctggga taaagacttc tgacagaaga aaagttgatt actgcctgta ctctacagaa   2340

gaggacctca aggatcaata atccaacaca ttattttctt ttcagagtat tataatatct   2400

ttggaagacc attagggaaa agaaattcct gcacaatggg aagaggagaa tggtgtggat   2460

atggttctga gttatagtgt cttatttaga tgctgtgaat tattgatgta ttacattatt   2520

tgcttttctc aactgctaga ggctacccca ttttcctttc cacaatcaga gccatttttg   2580

ttaaagtggc agttttttct gcaatctatt gttccattcc aatcatatcc ttctcgtttg   2640

agtactacta acgtttaaaa agggtcttgc ccttgaataa ctaagtcata caaatagaag   2700

gaaaaacaat ggtgaatttt ggagagctcc ccagctctca gcaacttcat ataagcatgg   2760

tggtatctta aaatggtggt ttgcagaaac catggtagcc aacagaacct cctgactttc   2820

acctgctttt aacctgaaaa tatattaata cgcctctgac atgagtccag ggagaggcaa   2880

gattgagcaa tagtcagtgg caccatttcc taaagtaact gaatcaatca atccagtcag   2940

gtaattattt tctattgggg aacttagaaa aaaaagtaaa gcaagaaata ttttctctcc   3000

tttatgatca gtgatacctt agagactttt cgaaagtcct tgttaaagat agttacaatg   3060

tgtggttaaa tgatgctaaa atattttcac aaccagagta gaaaacgtgc tggaacaaaa   3120

ttgcgaaggc ttttgcctcc cagtaaatag aaaggaaaat atattctagt aggtaagact   3180

gctgactctt tgaaaatctg aggtattttg aaaaattctg tgatagttgc tattaataaa   3240

ccaaaattgt atagaatcat cgttaatttt taatataaat cccattgaca aatgttgatg   3300

cactgtagtc actgctgagt taatagcg                                      3328


<210>  920
<211>  762
<212>  PRT
<213>  Homosapiens

<400>  920

Met Gly Asn Gly Ser Val Lys Pro Lys His Ser Lys His Pro Asp Gly 
1               5                   10                  15      


His Ser Gly Asn Leu Thr Thr Asp Ala Leu Arg Asn Lys Val Thr Glu 
            20                  25                  30          


Leu Glu Arg Glu Leu Arg Arg Lys Asp Ala Glu Ile Gln Glu Arg Glu 
        35                  40                  45              


Tyr His Leu Lys Glu Leu Arg Glu Gln Leu Ser Lys Gln Thr Val Ala 
    50                  55                  60                  


Ile Ala Glu Leu Thr Glu Glu Leu Gln Asn Lys Cys Ile Gln Leu Asn 
65                  70                  75                  80  


Lys Leu Gln Asp Val Val His Met Gln Gly Gly Ser Pro Leu Gln Ala 
                85                  90                  95      


Ser Pro Asp Lys Val Pro Leu Glu Val His Arg Lys Thr Ser Gly Leu 
            100                 105                 110         


Val Ser Leu His Ser Arg Arg Gly Ala Lys Ala Gly Val Ser Ala Glu 
        115                 120                 125             


Pro Thr Thr Arg Thr Tyr Asp Leu Asn Lys Pro Pro Glu Phe Ser Phe 
    130                 135                 140                 


Glu Lys Ala Arg Val Arg Lys Asp Ser Ser Glu Lys Lys Leu Ile Thr 
145                 150                 155                 160 


Asp Ala Leu Asn Lys Asn Gln Phe Leu Lys Arg Leu Asp Pro Gln Gln 
                165                 170                 175     


Ile Lys Asp Met Val Glu Cys Met Tyr Gly Arg Asn Tyr Gln Gln Gly 
            180                 185                 190         


Ser Tyr Ile Ile Lys Gln Gly Glu Pro Gly Asn His Ile Phe Val Leu 
        195                 200                 205             


Ala Glu Gly Arg Leu Glu Val Phe Gln Gly Glu Lys Leu Leu Ser Ser 
    210                 215                 220                 


Ile Pro Met Trp Thr Thr Phe Gly Glu Leu Ala Ile Leu Tyr Asn Cys 
225                 230                 235                 240 


Thr Arg Thr Ala Ser Val Lys Ala Ile Thr Asn Val Lys Thr Trp Ala 
                245                 250                 255     


Leu Asp Arg Glu Val Phe Gln Asn Ile Met Arg Arg Thr Ala Gln Ala 
            260                 265                 270         


Arg Asp Glu Gln Tyr Arg Asn Phe Leu Arg Ser Val Ser Leu Leu Lys 
        275                 280                 285             


Asn Leu Pro Glu Asp Lys Leu Thr Lys Ile Ile Asp Cys Leu Glu Val 
    290                 295                 300                 


Glu Tyr Tyr Asp Lys Gly Asp Tyr Ile Ile Arg Glu Gly Glu Glu Gly 
305                 310                 315                 320 


Ser Thr Phe Phe Ile Leu Ala Lys Gly Lys Val Lys Val Thr Gln Ser 
                325                 330                 335     


Thr Glu Gly His Asp Gln Pro Gln Leu Ile Lys Thr Leu Gln Lys Gly 
            340                 345                 350         


Glu Tyr Phe Gly Glu Lys Ala Leu Ile Ser Asp Asp Val Arg Ser Ala 
        355                 360                 365             


Asn Ile Ile Ala Glu Glu Asn Asp Val Ala Cys Leu Val Ile Asp Arg 
    370                 375                 380                 


Glu Thr Phe Asn Gln Thr Val Gly Thr Phe Glu Glu Leu Gln Lys Tyr 
385                 390                 395                 400 


Leu Glu Gly Tyr Val Ala Asn Leu Asn Arg Asp Asp Glu Lys Arg His 
                405                 410                 415     


Ala Lys Arg Ser Met Ser Asn Trp Lys Leu Ser Lys Ala Leu Ser Leu 
            420                 425                 430         


Glu Met Ile Gln Leu Lys Glu Lys Val Ala Arg Phe Ser Ser Ser Ser 
        435                 440                 445             


Pro Phe Gln Asn Leu Glu Ile Ile Ala Thr Leu Gly Val Gly Gly Phe 
    450                 455                 460                 


Gly Arg Val Glu Leu Val Lys Val Lys Asn Glu Asn Val Ala Phe Ala 
465                 470                 475                 480 


Met Lys Cys Ile Arg Lys Lys His Ile Val Asp Thr Lys Gln Gln Glu 
                485                 490                 495     


His Val Tyr Ser Glu Lys Arg Ile Leu Glu Glu Leu Cys Ser Pro Phe 
            500                 505                 510         


Ile Val Lys Leu Tyr Arg Thr Phe Lys Asp Asn Lys Tyr Val Tyr Met 
        515                 520                 525             


Leu Leu Glu Ala Cys Leu Gly Gly Glu Leu Trp Ser Ile Leu Arg Asp 
    530                 535                 540                 


Arg Gly Ser Phe Asp Glu Pro Thr Ser Lys Phe Cys Val Ala Cys Val 
545                 550                 555                 560 


Thr Glu Ala Phe Asp Tyr Leu His Arg Leu Gly Ile Ile Tyr Arg Asp 
                565                 570                 575     


Leu Lys Pro Glu Asn Leu Ile Leu Asp Ala Glu Gly Tyr Leu Lys Leu 
            580                 585                 590         


Val Asp Phe Gly Phe Ala Lys Lys Ile Gly Ser Gly Gln Lys Thr Trp 
        595                 600                 605             


Thr Phe Cys Gly Thr Pro Glu Tyr Val Ala Pro Glu Val Ile Leu Asn 
    610                 615                 620                 


Lys Gly His Asp Phe Ser Val Asp Phe Trp Ser Leu Gly Ile Leu Val 
625                 630                 635                 640 


Tyr Glu Leu Leu Thr Gly Asn Pro Pro Phe Ser Gly Val Asp Gln Met 
                645                 650                 655     


Met Thr Tyr Asn Leu Ile Leu Lys Gly Ile Glu Lys Met Asp Phe Pro 
            660                 665                 670         


Arg Lys Ile Thr Arg Arg Pro Glu Asp Leu Ile Arg Arg Leu Cys Arg 
        675                 680                 685             


Gln Asn Pro Thr Glu Arg Leu Gly Asn Leu Lys Asn Gly Ile Asn Asp 
    690                 695                 700                 


Ile Lys Lys His Arg Trp Leu Asn Gly Phe Asn Trp Glu Gly Leu Lys 
705                 710                 715                 720 


Ala Arg Ser Leu Pro Ser Pro Leu Gln Arg Glu Leu Lys Gly Pro Ile 
                725                 730                 735     


Asp His Ser Tyr Phe Asp Lys Tyr Pro Pro Glu Lys Gly Met Pro Pro 
            740                 745                 750         


Asp Glu Leu Ser Gly Trp Asp Lys Asp Phe 
        755                 760         


<210>  921
<211>  787
<212>  DNA
<213>  Homosapiens

<400>  921
tttggagttg tttacattca gacaaagctc atctggttgt ttgcagctag tcacaaggtg     60

gcccattgtc ctgccttgct tttctccatt atctctgggt caagttgttt ctttgataaa    120

tccaaatcat gaaaatagcc tgctgaaaga attcactttg aaaatgccac aaaacagaca    180

atggaaaaat gagatgaaca agtgcgaatc catcattctt ctcaggttct ggaaaaatgc    240

tggttttcag ctcctggaaa attctcacaa gacatctgtt ttgttttata tcttcatttg    300

tttccattca tctttcctac tgtagacact gtctatgatt tttttgtgtg ggggttttgg    360

caaagtgcat acgattactt tgaatttaga gaattaaatt gtatttatcc actgaaagct    420

gtttttaaga tctagctgtg ttgtcacttg gatatctagt ttattacttc tacttgcaaa    480

gtagtacaat gagataccaa accaccatat tttttccatc tattttctca attatggaca    540

cttttcaact tattactaca gtagggaagt taaaggctat ttgaattatt ggagaataga    600

gatacctagg atcagaatta ccaagtcata gaccgaaact ttggctaaga cctaaactta    660

atatgggtaa atattgttac attgctccct agaatattga tatggtttgg atttgtgtcc    720

ccacgcaaat ctcatgttga attgtaatcc tcaatgttgg aggtggggaa tggtaagggg    780

tgattag                                                              787


<210>  922
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  922

Met Pro Gln Asn Arg Gln Trp Lys Asn Glu Met Asn Lys Cys Glu Ser 
1               5                   10                  15      


Ile Ile Leu Leu Arg Phe Trp Lys Asn Ala Gly Phe Gln Leu Leu Glu 
            20                  25                  30          


Asn Ser His Lys Thr Ser Val Leu Phe Tyr Ile Phe Ile Cys Phe His 
        35                  40                  45              


Ser Ser Phe Leu Leu 
    50              


<210>  923
<211>  1750
<212>  DNA
<213>  Homosapiens

<400>  923
cggcttcctt tttctccaca cttctagcta ccttgttttt atcgttttcg gcacctgccc     60

ttccccagcg cccccaccac cccgagcact atgtatgatc gggctccccg cctgctcaaa    120

ttggctgaag gtggcagcac tgaggcccat gtgggtcctg gatcctacca ggtacctttc    180

ctgaagcagc aggcgacagg tagtaatgca ccatttcttt ctttgactgc cagagaaagt    240

acttttacca ttgcctctag cattgagaaa gctgttccag gtccaggaca ctataatgtt    300

tcagaagcac agaaaatttc aagatcacct acacttacca gaagtgttga tgttccttca    360

attccttctt gtggaaagtc atatggttat catattaatg atgatggcag tattataaaa    420

tgttttccac ctgcttgtga cagtacactt ggtccagcat actacaaacc tcaatttgat    480

gtttccaatg caactttgaa atacaaaggt atacattttg gcaactcttc aggaagacaa    540

gagttaccta aaaagtcagg tcctggtcca ggacagtatg atatagtcca gaaaaagaca    600

tcatattatg aaaatgttaa catcaagaga gatcaacaac aaaattattg ttcatttatc    660

ccacgactat atgaaataat agtattgcag gagaaaaaaa agagattttt acctatgaaa    720

tcaatcaccc cggctcctgg cacatataat gaacctcgaa ctgctctcaa gtctttgaag    780

aaaacatcag gactgaaaaa tattccattt ggtcaaagtg ctgttcgatt cacacaggac    840

atcaggacag aggaaatgcc aggtcctgga ttttataatg tcttgaacaa tactataatt    900

gccagtgtta gaaatatctg ctcaaagaaa cagaagaaaa gtgcatttgg ttcttctgtt    960

cctcggactt tcttctcggt tcagaaagaa gcttgtgcta cccctggacc tgctgattat   1020

caggaatttt ggcattcaca gggtgtggga atttctgatg aattacctaa cttgactaac   1080

aaatatgctg ctttcttgtc aagagccaaa agaactatga aagtaccaga tatggttatt   1140

ccagcgccag gcagctatga tgttcacaaa tcatatgaga tgtcccaagt taagcataaa   1200

tatatgccac ctcgtagttt agtggctaaa agaaaacatg cctcttttct tagtgcaact   1260

cctcggtgcc tagaaaaagt gactgatggg ccaggtcctg cagcatacaa tcctgtttta   1320

aggaaatctt gccccatacc cttatttgtg aaagcatcaa agcgctttga agagtccaaa   1380

gagattactc caggcccagc aacatatgag atatcccagg agaaaaagaa aggaaatctc   1440

attggtgaaa tggctgctga tataatgtga cataaattta tggcaaaaac ttaaaaaaca   1500

acttcatgga agtcagttta tttctttgtc attttaacaa aatttattcc aaatatagga   1560

gtaataaaag cataattttc acttgttcag gcattcgctc aggctttagt gactatatga   1620

cacaaccacg gagaaataaa ccttgaagac tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1740

aaaaaaaaaa                                                          1750


<210>  924
<211>  459
<212>  PRT
<213>  Homosapiens

<400>  924

Met Tyr Asp Arg Ala Pro Arg Leu Leu Lys Leu Ala Glu Gly Gly Ser 
1               5                   10                  15      


Thr Glu Ala His Val Gly Pro Gly Ser Tyr Gln Val Pro Phe Leu Lys 
            20                  25                  30          


Gln Gln Ala Thr Gly Ser Asn Ala Pro Phe Leu Ser Leu Thr Ala Arg 
        35                  40                  45              


Glu Ser Thr Phe Thr Ile Ala Ser Ser Ile Glu Lys Ala Val Pro Gly 
    50                  55                  60                  


Pro Gly His Tyr Asn Val Ser Glu Ala Gln Lys Ile Ser Arg Ser Pro 
65                  70                  75                  80  


Thr Leu Thr Arg Ser Val Asp Val Pro Ser Ile Pro Ser Cys Gly Lys 
                85                  90                  95      


Ser Tyr Gly Tyr His Ile Asn Asp Asp Gly Ser Ile Ile Lys Cys Phe 
            100                 105                 110         


Pro Pro Ala Cys Asp Ser Thr Leu Gly Pro Ala Tyr Tyr Lys Pro Gln 
        115                 120                 125             


Phe Asp Val Ser Asn Ala Thr Leu Lys Tyr Lys Gly Ile His Phe Gly 
    130                 135                 140                 


Asn Ser Ser Gly Arg Gln Glu Leu Pro Lys Lys Ser Gly Pro Gly Pro 
145                 150                 155                 160 


Gly Gln Tyr Asp Ile Val Gln Lys Lys Thr Ser Tyr Tyr Glu Asn Val 
                165                 170                 175     


Asn Ile Lys Arg Asp Gln Gln Gln Asn Tyr Cys Ser Phe Ile Pro Arg 
            180                 185                 190         


Leu Tyr Glu Ile Ile Val Leu Gln Glu Lys Lys Lys Arg Phe Leu Pro 
        195                 200                 205             


Met Lys Ser Ile Thr Pro Ala Pro Gly Thr Tyr Asn Glu Pro Arg Thr 
    210                 215                 220                 


Ala Leu Lys Ser Leu Lys Lys Thr Ser Gly Leu Lys Asn Ile Pro Phe 
225                 230                 235                 240 


Gly Gln Ser Ala Val Arg Phe Thr Gln Asp Ile Arg Thr Glu Glu Met 
                245                 250                 255     


Pro Gly Pro Gly Phe Tyr Asn Val Leu Asn Asn Thr Ile Ile Ala Ser 
            260                 265                 270         


Val Arg Asn Ile Cys Ser Lys Lys Gln Lys Lys Ser Ala Phe Gly Ser 
        275                 280                 285             


Ser Val Pro Arg Thr Phe Phe Ser Val Gln Lys Glu Ala Cys Ala Thr 
    290                 295                 300                 


Pro Gly Pro Ala Asp Tyr Gln Glu Phe Trp His Ser Gln Gly Val Gly 
305                 310                 315                 320 


Ile Ser Asp Glu Leu Pro Asn Leu Thr Asn Lys Tyr Ala Ala Phe Leu 
                325                 330                 335     


Ser Arg Ala Lys Arg Thr Met Lys Val Pro Asp Met Val Ile Pro Ala 
            340                 345                 350         


Pro Gly Ser Tyr Asp Val His Lys Ser Tyr Glu Met Ser Gln Val Lys 
        355                 360                 365             


His Lys Tyr Met Pro Pro Arg Ser Leu Val Ala Lys Arg Lys His Ala 
    370                 375                 380                 


Ser Phe Leu Ser Ala Thr Pro Arg Cys Leu Glu Lys Val Thr Asp Gly 
385                 390                 395                 400 


Pro Gly Pro Ala Ala Tyr Asn Pro Val Leu Arg Lys Ser Cys Pro Ile 
                405                 410                 415     


Pro Leu Phe Val Lys Ala Ser Lys Arg Phe Glu Glu Ser Lys Glu Ile 
            420                 425                 430         


Thr Pro Gly Pro Ala Thr Tyr Glu Ile Ser Gln Glu Lys Lys Lys Gly 
        435                 440                 445             


Asn Leu Ile Gly Glu Met Ala Ala Asp Ile Met 
    450                 455                 


<210>  925
<211>  1613
<212>  DNA
<213>  Homosapiens

<400>  925
gccacacagg ctccttggag taagagtgtg agaaactgga tgaagacagc tgtattcttt     60

tggaagcgtt cgagattggt ctgtctctac caactaaaaa cttctagctt aagtgcagag    120

atttaaggag atcaacaaaa actcagtcta gacatattat gaggctggga gggtatcaac    180

agacttgagt tcttgtcagc aagatcacct gcttttaata ttgtcctcag ggtctgagca    240

catctggaag tgaggtcaat caagttagac cccaaaaact tttgtgacaa cagtgaagag    300

gggaaaataa acacaccaca aacatgaacc tcaacccccc gacatctgct cttcagatcg    360

agggcaaagg cagccatatt atggctagaa atgtaagctg ctttctagtc aggcacaccc    420

ctcatcccag aagagtctgc cacatcaaag gcttgaataa cattccaatc tgtactgtga    480

atgatgatga gaatgcattt ggaacattgt gggaagttgg ccagtctaac tacttagaga    540

agaacaggat accatttgcc aattgcagtt accccccgag cactgcagtc cagaagagcc    600

ctgtaagagg aatgtcgcca gccccaaacg gtgccaaagt gcctccacgg cctcattctg    660

agcccagtag aaaaattaaa gagtgcttca aaacttccag tgagaatccc ttagtaatta    720

aaaaggaaga aattaaggcc aaaagaccac catcacctcc aaaggcatgc tctactcctg    780

gctcctgttc ttcagggatg acaagtacca agaatgatgt gaaagcaaac accatttgca    840

taccaaacta tctggatcag gaaataaaaa tcctggcaaa gctctgtagc attttgcata    900

ctgattctct ggcagaagtt ttacagtggc tgcttcatgc aacttcaaaa gaaaaagagt    960

gggtctcagc tttgattcat tctgagcttg ccgagataaa cctgttaact catcacagaa   1020

gaaacacctc aatggaacca gcagcagaga ctgggaagcc acccacagtt aaatcaccac   1080

ccacagttaa attgccccca aattttactg caaaatcaaa agtgctgacc agagatacag   1140

aaggggatca accaaccaga gtgtcaagtc aaggatctga agaaaacaag gaagtaccaa   1200

aagaggctga gcacaagcct ccactactta taagaagaaa taatatgaaa atacctgttg   1260

cagaatattt cagcaaacca aattctcctc ccaggcctaa cactcaggag agtggatcag   1320

caaaaccagt gtcagcaagg agtatacaag aatacaacct ctgtccccaa agagcatgtt   1380

atccttcaac acaccggagg tagaagttct agactgggtg aattctttca tgaatatgag   1440

cttcacattt acatcatcaa attatttttc aaatgaatat ttttggtatt gaggaatcaa   1500

gtggtcctct ttatggtggc acatgtaaat ctaaaaatac ctgtatgtaa tgctacaaat   1560

aaatattact ggaaatgata tttccatttg tagttaaaaa aaaaaaaaaa aaa          1613


<210>  926
<211>  359
<212>  PRT
<213>  Homosapiens

<400>  926

Met Asn Leu Asn Pro Pro Thr Ser Ala Leu Gln Ile Glu Gly Lys Gly 
1               5                   10                  15      


Ser His Ile Met Ala Arg Asn Val Ser Cys Phe Leu Val Arg His Thr 
            20                  25                  30          


Pro His Pro Arg Arg Val Cys His Ile Lys Gly Leu Asn Asn Ile Pro 
        35                  40                  45              


Ile Cys Thr Val Asn Asp Asp Glu Asn Ala Phe Gly Thr Leu Trp Glu 
    50                  55                  60                  


Val Gly Gln Ser Asn Tyr Leu Glu Lys Asn Arg Ile Pro Phe Ala Asn 
65                  70                  75                  80  


Cys Ser Tyr Pro Pro Ser Thr Ala Val Gln Lys Ser Pro Val Arg Gly 
                85                  90                  95      


Met Ser Pro Ala Pro Asn Gly Ala Lys Val Pro Pro Arg Pro His Ser 
            100                 105                 110         


Glu Pro Ser Arg Lys Ile Lys Glu Cys Phe Lys Thr Ser Ser Glu Asn 
        115                 120                 125             


Pro Leu Val Ile Lys Lys Glu Glu Ile Lys Ala Lys Arg Pro Pro Ser 
    130                 135                 140                 


Pro Pro Lys Ala Cys Ser Thr Pro Gly Ser Cys Ser Ser Gly Met Thr 
145                 150                 155                 160 


Ser Thr Lys Asn Asp Val Lys Ala Asn Thr Ile Cys Ile Pro Asn Tyr 
                165                 170                 175     


Leu Asp Gln Glu Ile Lys Ile Leu Ala Lys Leu Cys Ser Ile Leu His 
            180                 185                 190         


Thr Asp Ser Leu Ala Glu Val Leu Gln Trp Leu Leu His Ala Thr Ser 
        195                 200                 205             


Lys Glu Lys Glu Trp Val Ser Ala Leu Ile His Ser Glu Leu Ala Glu 
    210                 215                 220                 


Ile Asn Leu Leu Thr His His Arg Arg Asn Thr Ser Met Glu Pro Ala 
225                 230                 235                 240 


Ala Glu Thr Gly Lys Pro Pro Thr Val Lys Ser Pro Pro Thr Val Lys 
                245                 250                 255     


Leu Pro Pro Asn Phe Thr Ala Lys Ser Lys Val Leu Thr Arg Asp Thr 
            260                 265                 270         


Glu Gly Asp Gln Pro Thr Arg Val Ser Ser Gln Gly Ser Glu Glu Asn 
        275                 280                 285             


Lys Glu Val Pro Lys Glu Ala Glu His Lys Pro Pro Leu Leu Ile Arg 
    290                 295                 300                 


Arg Asn Asn Met Lys Ile Pro Val Ala Glu Tyr Phe Ser Lys Pro Asn 
305                 310                 315                 320 


Ser Pro Pro Arg Pro Asn Thr Gln Glu Ser Gly Ser Ala Lys Pro Val 
                325                 330                 335     


Ser Ala Arg Ser Ile Gln Glu Tyr Asn Leu Cys Pro Gln Arg Ala Cys 
            340                 345                 350         


Tyr Pro Ser Thr His Arg Arg 
        355                 


<210>  927
<211>  3711
<212>  DNA
<213>  Homosapiens

<400>  927
gtttgctggc tgggagccta gaagggatag tgggcgaggc tccgccccgt ggtggggcgc     60

tttccgtcgg cgtgtgtttt ggggttgcca tcggcccgta gtatgtgaaa agtgagtttg    120

caaagaatca gtgggaaatc tgtactctaa agggccggaa agcgtgttat ggccctgcca    180

cttcgtggct agagaccgtg ggctttacct ctttaaagct gccttacctc atttttcctg    240

caaagggctg acgtcgctga actctctgaa atgtagagag cccgagggga agttgctgca    300

gaggcaccaa ataatgtcat ctgaaatgtt gccagcattt attgaaactt ctaatgttga    360

caaaaagcaa ggcataaatg aagatcaaga ggagagccag aagccaagat taggtgaagg    420

gtgtgaacca atatctaaac gacaaatgaa aaaactaata aaacagaaac aatgggaaga    480

gcaacgggaa ctccgcaaac aaaagcgaaa agaaaaacgc aagaggaaaa aattagagcg    540

acaatgtcaa atggaaccaa actcagatgg acatgacaga aaacgtgttc gaagagatgt    600

tgttcatagc acccttcgcc ttattattga ctgtagtttt gatcacttga tggtattaaa    660

ggacattaag aaacttcata agcagattca acgatgttac gcagaaaacc gacgggcact    720

gcatcctgtg cagttttact tgacaagcca cggaggccag ctgaaaaaga acatggatga    780

aaatgacaaa ggatgggtca actggaagga tatccatatc aaaccagagc actatagtga    840

actcataaag aaagaagacc tgatttacct tacgtcagat tcacctaata tactgaagga    900

attagatgaa tcaaaggcct atgtgattgg aggattagta gatcacaacc atcacaaggg    960

actcacatat aaacaagcgt cagattatgg aatcaatcat gcacagctcc cacttggaaa   1020

ttttgtgaag atgaatagtc gaaaagtttt ggcagttaat catgtgtttg aaattattct   1080

ggaatacctg gaaacaagag actggcaaga agcatttttt actatcttgc cccaacggaa   1140

aggagctgtt cccacagaca aagcctgtga aagtgcttct catgacaatc agtctgtcag   1200

gatggaggaa ggtggatcgg acagtgattc cagtgaggag gaatatagca gaaatgaact   1260

agattcacca catgaagaaa agcaggataa ggaaaatcac actgaatcta cagtgaactc   1320

tctgccacac taatgttacc tggtttcctt ttagtttaag gaaaaattag gagaaagtga   1380

ggtgctatat agaatattga aattggaaga acattttatt ttctcttatt tctgttgtga   1440

tttttaaaaa cttttttttg gacctaaata ataataaaaa aaaaagccct ttaaactttg   1500

taaggaaata ttttttgatt ttgcgtaaga agatttaaat gtgtatgtga ttttttttgt   1560

ttttgttttt aaagcctcag tagtttctag ataattttac tgtattagta tattttcatt   1620

ctttcatttt atattcttta gaatgtgcct tctgaccttt cagtttttta attttatagt   1680

cacatcaaca tctttatgat ctattgccta tatatctgtg agggcacata ttcataaata   1740

tactgtcaat ctatcagcat ttgtgtatgg taggttaccc tctatttgca gcttttatgt   1800

ttaaattagt tacttgaaag aatgtagtaa ttttaggaag aagtatcagt ttgatagact   1860

taataattca tttcttttgg actatggagc gcatatctgt tccttcttta tgatgccttt   1920

ttatggttct gaagtaatta ctgaagagtt gagaatctct ttaatgcatt ttcttaattc   1980

ttacaatggt gataagttac ttcaattata aaattgaatt ttgcagacta aattatttta   2040

taaggctgtt gctattgaaa gatcaatttt gtctttacct gcatttaaaa tggaacagct   2100

cttagcagct gtggtttttt tttccatatt ttttttaaat ttgttggctc ttaagatgaa   2160

taaagtttat aggtgcatct gcctcctctt ctctaagaat atgcatacta atgtttgttt   2220

ctataaatca aatacacatg tgataatatg catgtaaata cataactatc ctcatcatgt   2280

atggctctca gttcttaatt gatgataaca tgattgaatt gccatatatc tgtattactt   2340

gtgtgaatgg ttgtgttgaa cacgctaaga acaatttgaa ttttattaag tacaaaaatc   2400

cttaacgttt gtatgggaac attggcaaga aagaatagtg tgaaagggaa ctgttttagt   2460

ttcctatcag taattgtaca tgcagttaaa tgtttaaggt aaaatgattg gtctctgtca   2520

cagctaaaag atttcagtag ccttcattga gtttgggtaa aataagttgc tgttcttttg   2580

tcttcttttt aatatataaa agttatattt aaaaagtata taacatacta tatatgttac   2640

atactaacat atatatacac aacagaaagt ttattggatt tagtactgat atttactgtc   2700

tatttttgtt actttgttct tagtaatcta ttatagttac ctattttaag gtaaggtctg   2760

taggcaagat atgtaagtaa agacaagccc tacaatttta aaataacaaa gcttatgtct   2820

taagttgtat tttttcaaag gttcatgttt ttctgagtaa atgtggttta ttagcatgaa   2880

atattatgcc ttttacttaa attattttat gtaaaatagg gcactgttta attatgaaag   2940

ggggaaaatc attccaaata agagtttaat ttttattaat tataaaaaac tctgtattag   3000

tttcctagat gtgctagaac aaattaccac aaactgggtg gctttaaaca acagaaattt   3060

attctcttaa cagttccaga gactaaatgt ccagactcac aatgtcccag tgccatgctt   3120

cctccttagg ccctaggaaa gaatacttcc tagcctcttc ctggcttttg gtggttgcca   3180

gcaatccctg ctgttcctta gcctatagtg gcttgactcc aatctcagtt ttgttgtcaa   3240

gtggtcttct accctgtctt ctatgtttgt atccgtgtcc aaactctttt tctagggaga   3300

ccagcactgg attagagttc accatgatcc aatatgacct catcttgact acatccgcaa   3360

agaccctgtc tccaaataag gtcacattta cagggtacca tgtgttagga tttgacatat   3420

cttttggggg acacaattct acccactaca ggcccatatc ttatctagga tgttggtggc   3480

aagaaggtga agattactac ctcttttgat ataactagtt tctgaggtat ttaaaaattt   3540

ggttttaaaa atattaagct ttttgctcat ttgcatgtat acttttctct caacattgtt   3600

ttggtttatt taggttattt gttaaaactt cagtaaatac taaagttact tgtattagaa   3660

cataataaaa gtagagaatt aaactaccta aaaaagaaaa aaaaaaaaaa a            3711


<210>  928
<211>  339
<212>  PRT
<213>  Homosapiens

<400>  928

Met Ser Ser Glu Met Leu Pro Ala Phe Ile Glu Thr Ser Asn Val Asp 
1               5                   10                  15      


Lys Lys Gln Gly Ile Asn Glu Asp Gln Glu Glu Ser Gln Lys Pro Arg 
            20                  25                  30          


Leu Gly Glu Gly Cys Glu Pro Ile Ser Lys Arg Gln Met Lys Lys Leu 
        35                  40                  45              


Ile Lys Gln Lys Gln Trp Glu Glu Gln Arg Glu Leu Arg Lys Gln Lys 
    50                  55                  60                  


Arg Lys Glu Lys Arg Lys Arg Lys Lys Leu Glu Arg Gln Cys Gln Met 
65                  70                  75                  80  


Glu Pro Asn Ser Asp Gly His Asp Arg Lys Arg Val Arg Arg Asp Val 
                85                  90                  95      


Val His Ser Thr Leu Arg Leu Ile Ile Asp Cys Ser Phe Asp His Leu 
            100                 105                 110         


Met Val Leu Lys Asp Ile Lys Lys Leu His Lys Gln Ile Gln Arg Cys 
        115                 120                 125             


Tyr Ala Glu Asn Arg Arg Ala Leu His Pro Val Gln Phe Tyr Leu Thr 
    130                 135                 140                 


Ser His Gly Gly Gln Leu Lys Lys Asn Met Asp Glu Asn Asp Lys Gly 
145                 150                 155                 160 


Trp Val Asn Trp Lys Asp Ile His Ile Lys Pro Glu His Tyr Ser Glu 
                165                 170                 175     


Leu Ile Lys Lys Glu Asp Leu Ile Tyr Leu Thr Ser Asp Ser Pro Asn 
            180                 185                 190         


Ile Leu Lys Glu Leu Asp Glu Ser Lys Ala Tyr Val Ile Gly Gly Leu 
        195                 200                 205             


Val Asp His Asn His His Lys Gly Leu Thr Tyr Lys Gln Ala Ser Asp 
    210                 215                 220                 


Tyr Gly Ile Asn His Ala Gln Leu Pro Leu Gly Asn Phe Val Lys Met 
225                 230                 235                 240 


Asn Ser Arg Lys Val Leu Ala Val Asn His Val Phe Glu Ile Ile Leu 
                245                 250                 255     


Glu Tyr Leu Glu Thr Arg Asp Trp Gln Glu Ala Phe Phe Thr Ile Leu 
            260                 265                 270         


Pro Gln Arg Lys Gly Ala Val Pro Thr Asp Lys Ala Cys Glu Ser Ala 
        275                 280                 285             


Ser His Asp Asn Gln Ser Val Arg Met Glu Glu Gly Gly Ser Asp Ser 
    290                 295                 300                 


Asp Ser Ser Glu Glu Glu Tyr Ser Arg Asn Glu Leu Asp Ser Pro His 
305                 310                 315                 320 


Glu Glu Lys Gln Asp Lys Glu Asn His Thr Glu Ser Thr Val Asn Ser 
                325                 330                 335     


Leu Pro His 
            


<210>  929
<211>  3392
<212>  DNA
<213>  Homosapiens

<400>  929
actccctcac tggctgccat tgaaagagtc cacttctcag tgactcctag ctgggcactg     60

gatgcagttg aggattgctg gtcaatatga ttcttcttgc tgtgcttttt ctctgcttca    120

tttcctcata ttcagcttct gttaaaggtc acacaactgg tctctcatta aataatgacc    180

ggctgtacaa gctcacgtac tccactgaag ttcttcttga tcggggcaaa ggaaaactgc    240

aagacagcgt gggctaccgc atttcctcca acgtggatgt ggccttacta tggaggaatc    300

ctgatggtga tgatgaccag ttgatccaaa taacgatgaa ggatgtaaat gttgaaaatg    360

tgaatcagca gagaggagag aagagcatct tcaaaggaaa aagcccatct aaaataatgg    420

gaaaggaaaa cttggaagct ctgcaaagac ctacgctcct tcatctaatc catggaaagg    480

tcaaagagtt ctactcatat caaaatgagg cagtggccat agaaaatatc aagagaggtc    540

tggctagcct atttcagaca cagttaagct ctggaaccac caatgaggta gatatctctg    600

gaaattgtaa agtgacctac caggctcatc aagacaaagt gatcaaaatt aaggccttgg    660

attcatgcaa aatagcgagg tctggattta cgaccccaaa tcaggtcttg ggtgtcagtt    720

caaaagctac atctgtcacc acctataaga tagaagacag ctttgttata gctgtgcttg    780

ctgaagaaac acacaatttt ggactgaatt tcctacaaac cattaagggg aaaatagtat    840

cgaagcagaa attagagctg aagacaaccg aagcaggccc aagattgatg tctggaaagc    900

aggctgcagc cataatcaaa gcagttgatt caaagtacac ggccattccc attgtggggc    960

aggtcttcca gagccactgt aaaggatgtc cttctctctc ggagctctgg cggtccacca   1020

ggaaatacct gcagcctgac aacctttcca aggctgaggc tgtcagaaac ttcctggcct   1080

tcattcagca cctcaggact gcgaagaaag aagagatcct tcaaatacta aagatggaaa   1140

ataaggaagt attacctcag ctggtggatg ctgtcacctc tgctcagacc tcagactcat   1200

tagaagccat tttggacttt ttggatttca aaagtgacag cagcattatc ctccaggaga   1260

ggtttctcta tgcctgtgga tttgcttctc atcccaatga agaactcctg agagccctca   1320

ttagtaagtt caaaggttct attggtagca gtgacatcag agaaactgtt atgatcatca   1380

ctgggacact tgtcagaaag ttgtgtcaga atgaaggctg caaactcaaa gcagtagtgg   1440

aagctaagaa gttaatcctg ggaggacttg aaaaagcaga gaaaaaagag gacaccagga   1500

tgtatctgct ggctttgaag aatgccctgc ttccagaagg catcccaagt cttctgaagt   1560

atgcagaagc aggagaaggg cccatcagcc acctggctac cactgctctc cagagatatg   1620

atctcccttt cataactgat gaggtgaaga agaccttaaa cagaatatac caccaaaacc   1680

gtaaagttca tgaaaagact gtgcgcactg ctgcagctgc tatcatttta aataacaatc   1740

catcctacat ggacgtcaag aacatcctgc tgtctattgg ggagcttccc caagaaatga   1800

ataaatacat gctcgccatt gttcaagaca tcctacgttt ggaaatgcct gcaagcaaaa   1860

ttgtccgtcg agttctgaag gaaatggtcg ctcacaatta tgaccgtttc tccaggagtg   1920

gatcttcttc tgcctacact ggctacatag aacgtagtcc ccgttcggca tctacttaca   1980

gcctagacat tctctactcg ggttctggca ttctaaggag aagtaacctg aacatctttc   2040

agtacattgg gaaggctggt cttcacggta gccaggtggt tattgaagcc caaggactgg   2100

aagccttaat cgcagccacc cctgacgagg gggaggagaa ccttgactcc tatgctggta   2160

tgtcagccat cctctttgat gttcagctca gacctgtcac ctttttcaac ggatacagtg   2220

atttgatgtc caaaatgctg tcagcatctg gcgaccctat cagtgtggtg aaaggactta   2280

ttctgctaat agatcattct caggaacttc agttacaatc tggactaaaa gccaatatag   2340

aggtccaggg tggtctagct attgatattt caggtgcaat ggagtttagc ttgtggtatc   2400

gtgagtctaa aacccgagtg aaaaataggg tgactgtggt aataaccact gacatcacag   2460

tggactcctc ttttgtgaaa gctggcctgg aaaccagtac agaaacagaa gcaggcttgg   2520

agtttatctc cacagtgcag ttttctcagt acccattctt agtttgcatg cagatggaca   2580

aggatgaagc tccattcagg caatttgaga aaaagtacga aaggctgtcc acaggcagag   2640

gttatgtctc tcagaaaaga aaagaaagcg tattagcagg atgtgaattc ccgctccatc   2700

aagagaactc agagatgtgc aaagtggtgt ttgcccctca gccggatagt acttccagcg   2760

gatggttttg aaactgacct gtgatatttt acttgaattt gtctccccga aagggacaca   2820

atgtggcatg actaagtact tgctctctga gagcacagcg tttacatatt tacctgtatt   2880

taagattttt gtaaaaagct acaaaaaact gcagtttgat caaatttggg tatatgcagt   2940

atgctaccca cagcgtcatt ttgaatcatc atgtgacgct ttcaacaacg ttcttagttt   3000

acttatacct ctctcaaatc tcatttggta cagtcagaat agttattctc taagaggaaa   3060

ctagtgtttg ttaaaaacaa aaataaaaac aaaaccacac aaggagaacc caattttgtt   3120

tcaacaattt ttgatcaatg tatatgaagc tcttgatagg acttccttaa gcatgacggg   3180

aaaaccaaac acgttcccta atcaggaaaa aaaaaaaaaa aaaaaagtaa gacacaaaca   3240

aaccattttt ttctcttttt ttggagttgg gggcccaggg agaagggaca aggcttttaa   3300

aagacttgtt agccaacttc aagaattaat atttatgtct ctgttattgt tagttttaag   3360

ccttaaggta gaaggcacat agaaataaca tc                                 3392


<210>  930
<211>  894
<212>  PRT
<213>  Homosapiens

<400>  930

Met Ile Leu Leu Ala Val Leu Phe Leu Cys Phe Ile Ser Ser Tyr Ser 
1               5                   10                  15      


Ala Ser Val Lys Gly His Thr Thr Gly Leu Ser Leu Asn Asn Asp Arg 
            20                  25                  30          


Leu Tyr Lys Leu Thr Tyr Ser Thr Glu Val Leu Leu Asp Arg Gly Lys 
        35                  40                  45              


Gly Lys Leu Gln Asp Ser Val Gly Tyr Arg Ile Ser Ser Asn Val Asp 
    50                  55                  60                  


Val Ala Leu Leu Trp Arg Asn Pro Asp Gly Asp Asp Asp Gln Leu Ile 
65                  70                  75                  80  


Gln Ile Thr Met Lys Asp Val Asn Val Glu Asn Val Asn Gln Gln Arg 
                85                  90                  95      


Gly Glu Lys Ser Ile Phe Lys Gly Lys Ser Pro Ser Lys Ile Met Gly 
            100                 105                 110         


Lys Glu Asn Leu Glu Ala Leu Gln Arg Pro Thr Leu Leu His Leu Ile 
        115                 120                 125             


His Gly Lys Val Lys Glu Phe Tyr Ser Tyr Gln Asn Glu Ala Val Ala 
    130                 135                 140                 


Ile Glu Asn Ile Lys Arg Gly Leu Ala Ser Leu Phe Gln Thr Gln Leu 
145                 150                 155                 160 


Ser Ser Gly Thr Thr Asn Glu Val Asp Ile Ser Gly Asn Cys Lys Val 
                165                 170                 175     


Thr Tyr Gln Ala His Gln Asp Lys Val Ile Lys Ile Lys Ala Leu Asp 
            180                 185                 190         


Ser Cys Lys Ile Ala Arg Ser Gly Phe Thr Thr Pro Asn Gln Val Leu 
        195                 200                 205             


Gly Val Ser Ser Lys Ala Thr Ser Val Thr Thr Tyr Lys Ile Glu Asp 
    210                 215                 220                 


Ser Phe Val Ile Ala Val Leu Ala Glu Glu Thr His Asn Phe Gly Leu 
225                 230                 235                 240 


Asn Phe Leu Gln Thr Ile Lys Gly Lys Ile Val Ser Lys Gln Lys Leu 
                245                 250                 255     


Glu Leu Lys Thr Thr Glu Ala Gly Pro Arg Leu Met Ser Gly Lys Gln 
            260                 265                 270         


Ala Ala Ala Ile Ile Lys Ala Val Asp Ser Lys Tyr Thr Ala Ile Pro 
        275                 280                 285             


Ile Val Gly Gln Val Phe Gln Ser His Cys Lys Gly Cys Pro Ser Leu 
    290                 295                 300                 


Ser Glu Leu Trp Arg Ser Thr Arg Lys Tyr Leu Gln Pro Asp Asn Leu 
305                 310                 315                 320 


Ser Lys Ala Glu Ala Val Arg Asn Phe Leu Ala Phe Ile Gln His Leu 
                325                 330                 335     


Arg Thr Ala Lys Lys Glu Glu Ile Leu Gln Ile Leu Lys Met Glu Asn 
            340                 345                 350         


Lys Glu Val Leu Pro Gln Leu Val Asp Ala Val Thr Ser Ala Gln Thr 
        355                 360                 365             


Ser Asp Ser Leu Glu Ala Ile Leu Asp Phe Leu Asp Phe Lys Ser Asp 
    370                 375                 380                 


Ser Ser Ile Ile Leu Gln Glu Arg Phe Leu Tyr Ala Cys Gly Phe Ala 
385                 390                 395                 400 


Ser His Pro Asn Glu Glu Leu Leu Arg Ala Leu Ile Ser Lys Phe Lys 
                405                 410                 415     


Gly Ser Ile Gly Ser Ser Asp Ile Arg Glu Thr Val Met Ile Ile Thr 
            420                 425                 430         


Gly Thr Leu Val Arg Lys Leu Cys Gln Asn Glu Gly Cys Lys Leu Lys 
        435                 440                 445             


Ala Val Val Glu Ala Lys Lys Leu Ile Leu Gly Gly Leu Glu Lys Ala 
    450                 455                 460                 


Glu Lys Lys Glu Asp Thr Arg Met Tyr Leu Leu Ala Leu Lys Asn Ala 
465                 470                 475                 480 


Leu Leu Pro Glu Gly Ile Pro Ser Leu Leu Lys Tyr Ala Glu Ala Gly 
                485                 490                 495     


Glu Gly Pro Ile Ser His Leu Ala Thr Thr Ala Leu Gln Arg Tyr Asp 
            500                 505                 510         


Leu Pro Phe Ile Thr Asp Glu Val Lys Lys Thr Leu Asn Arg Ile Tyr 
        515                 520                 525             


His Gln Asn Arg Lys Val His Glu Lys Thr Val Arg Thr Ala Ala Ala 
    530                 535                 540                 


Ala Ile Ile Leu Asn Asn Asn Pro Ser Tyr Met Asp Val Lys Asn Ile 
545                 550                 555                 560 


Leu Leu Ser Ile Gly Glu Leu Pro Gln Glu Met Asn Lys Tyr Met Leu 
                565                 570                 575     


Ala Ile Val Gln Asp Ile Leu Arg Leu Glu Met Pro Ala Ser Lys Ile 
            580                 585                 590         


Val Arg Arg Val Leu Lys Glu Met Val Ala His Asn Tyr Asp Arg Phe 
        595                 600                 605             


Ser Arg Ser Gly Ser Ser Ser Ala Tyr Thr Gly Tyr Ile Glu Arg Ser 
    610                 615                 620                 


Pro Arg Ser Ala Ser Thr Tyr Ser Leu Asp Ile Leu Tyr Ser Gly Ser 
625                 630                 635                 640 


Gly Ile Leu Arg Arg Ser Asn Leu Asn Ile Phe Gln Tyr Ile Gly Lys 
                645                 650                 655     


Ala Gly Leu His Gly Ser Gln Val Val Ile Glu Ala Gln Gly Leu Glu 
            660                 665                 670         


Ala Leu Ile Ala Ala Thr Pro Asp Glu Gly Glu Glu Asn Leu Asp Ser 
        675                 680                 685             


Tyr Ala Gly Met Ser Ala Ile Leu Phe Asp Val Gln Leu Arg Pro Val 
    690                 695                 700                 


Thr Phe Phe Asn Gly Tyr Ser Asp Leu Met Ser Lys Met Leu Ser Ala 
705                 710                 715                 720 


Ser Gly Asp Pro Ile Ser Val Val Lys Gly Leu Ile Leu Leu Ile Asp 
                725                 730                 735     


His Ser Gln Glu Leu Gln Leu Gln Ser Gly Leu Lys Ala Asn Ile Glu 
            740                 745                 750         


Val Gln Gly Gly Leu Ala Ile Asp Ile Ser Gly Ala Met Glu Phe Ser 
        755                 760                 765             


Leu Trp Tyr Arg Glu Ser Lys Thr Arg Val Lys Asn Arg Val Thr Val 
    770                 775                 780                 


Val Ile Thr Thr Asp Ile Thr Val Asp Ser Ser Phe Val Lys Ala Gly 
785                 790                 795                 800 


Leu Glu Thr Ser Thr Glu Thr Glu Ala Gly Leu Glu Phe Ile Ser Thr 
                805                 810                 815     


Val Gln Phe Ser Gln Tyr Pro Phe Leu Val Cys Met Gln Met Asp Lys 
            820                 825                 830         


Asp Glu Ala Pro Phe Arg Gln Phe Glu Lys Lys Tyr Glu Arg Leu Ser 
        835                 840                 845             


Thr Gly Arg Gly Tyr Val Ser Gln Lys Arg Lys Glu Ser Val Leu Ala 
    850                 855                 860                 


Gly Cys Glu Phe Pro Leu His Gln Glu Asn Ser Glu Met Cys Lys Val 
865                 870                 875                 880 


Val Phe Ala Pro Gln Pro Asp Ser Thr Ser Ser Gly Trp Phe 
                885                 890                 


<210>  931
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  931
atggggcatg ccagtgggtc acatttcctc tctgaatctc cctccaagcc gcactgtact     60

cttgaaggga aagggacaag gcttcacaag aaacagcaca tgctttcctt tcatttctgg    120

aagtcccggg gtcaacctac agatgctgct tcttccgtgg ccgatggcat tcagactcct    180

cgctgctgcc gacggtgcca ggcaaacaac tggacaggac agctcagcta cagaacactg    240

gccacagtct cggccggagc agcagccccc cagccacaga ccacctccac cgcctcatcc    300

aggagccttc ccacctccct caggcttgct gcggccccgc cacaggggct gaagaactgg    360

gaggtggtgg cagcagtggc agcagtgcct acagccttgg ggccagtcca gatacgtggg    420

accctgcttc gggcaactct gcagcccctc cggggccaga gacggaccca agacttcccc    480

agcgatcacc attgtctctt cctgtcgctg aaacctgggc aagggctcat aatggaagct    540

gcccctcctg agctgaattc gaaagcaaga caggcggagg tgggggacgg ggtgagcagt    600

gctcaagaca gccaggagct caagcagcag ctgtggccac ttcccaagcc ttcagcctcc    660

tcccagcgag aagcgaaata tgtggacatg tgtgcttcag ctgaagtcca gagggagagt    720

ccccagacca tgaaacttac cctggggcac tgccctgggg gtcagagggc ctctaggagc    780

ccaaaggaga aagcccaaga tgaacccagc agcaagactc caagccccca gaacaatcct    840

gcctcctccc aactctctag atcccagcac tctgcctctg aagagggtgg caatttctca    900

tcttcctcat cctcctcccc gatgaacaaa gcagaagagg atggcctttc caaaatggag    960

gactccacca catccacagg ggctctggcc acctcctctt catccttagg cttcgagagt   1020

gagagtggtg aaagtgaagg ttgccaggcc ggcagcaggg acccccccaa agtcgaagag   1080

gctcactaca tcaccaccca tgagatccag ctgagtgagg tggaacagga catggatttc   1140

gacgtgggac tggcctcccg ctgggatttc gaggacaaca acgtgatcta ctcgttcgtg   1200

gattatgctt cctttggtgg cagcgacgag accccagggg acatcaccag tctgaccgaa   1260

gaggacgacg acaacagctg ctacctcagc accactccca gcaccaacac cacccggacg   1320

cccagcccta caagcagcga cctggcccgc cccaatgcag gccgcagtgg ccgcgacacc   1380

agcagcaccg aagcagcttc aggggcagca gccgccgccg caagcagctg tgggagtgca   1440

gcaagccaga tcctcctatc aatcaaaccg gcttcccggg ctataaatga gcctagcaac   1500

gtgcgtgcaa agcaaaacat tatttatgct gccaagcatg aaggcgacat gagcctccgc   1560

gtctctacag ctgctgaaca caattcaagt tcgctgaagc aaaacccggc tgcagcagtg   1620

gctcaggacc atgcaaagaa attcattgct gtacctgctc gcctgcaaac caggtgcggg   1680

gccatccggg cgaaggagct ggtggactac tccagcggag cctccagtgc cgtgagcgaa   1740

ctggacgatg cggacaaaga ggtgcgtaac ctgacctccc gggccttccg gagcctggct   1800

tacccctact ttgaggctct gaacatcagc tcccgggagt cctccaccac gctctccgaa   1860

gtgggctttg ggcgctggtc aactttcctg gacttaaaat gtgggggtgt tggggccagg   1920

gtggagcaga gcctcctcag gagcagcgcg gcctctgtgg ctgcaggtct gaggaagggc   1980

agtggggccc gggccactgc cgaccagctc tacatccagt ccaagaagtc tcagaccaag   2040

gccttggagt tcgtggtcag caaagtcgag ggggaaatca aacatgtgga gacgcccctg   2100

tgtttccaga agcaggtcca gacgggctcc cgcgtcgtca cccttttgga gcccctgaat   2160

gtacgcagtg agagcaaagc cagctcggcc cctgggcccg gcagggccac caaaggcccc   2220

ggcaagggtc ccgggtcggc atacacggac gacggctccg agacctccga gggcagcaag   2280

cccacctccc gcgccgatgg cccccagaag tccaagttcg cctccagtct gctcaaaaat   2340

gtcatttcca agaagatgca gcgggaacac gagttcaaaa tggagagggg agaagtcatg   2400

gatacatccc accacctctc aggcacctcc aaggagacgg agggcgcccg cgggagcgag   2460

aggcagcgag agaggggcct gcagaggcag agctctcgtc actccgaggc cggctccgag   2520

tacacagtgg tcagcatgtc cgacgcgggc ggggaggggt ccgtggcggg ctccaaatct   2580

ccagtcttca aagccagtac tcctcgcgag cgcaacgcag gccctggccg gaatttcacc   2640

gatggacaca cagaagtgtg tgaaattaaa aagagtgcct cagagaccgt caagggcatc   2700

ttcctccgta gtcagaacag tgcgttccgg tcatggaagg agaaagaggc cgagaagagg   2760

gaggaacaag cccctatagg gaagctgaag ctgcccaaag gaggcgactg gcgggctgat   2820

ctcggggaga tttctgccag caagaacacc atcatgtctc gcctctttgt ccccaacatc   2880

cagcagacac ccaaggacaa gcagccgagg aagcaggcca ccaagtaccc tgctgctcag   2940

gccacctcca cagcggtgat cagacccaag gctcccgaaa tcaagatccg gctggggagt   3000

gtgcagcagc cgagctcaga cttcaacatt gccaagttgc tcacgcccaa gctggccggt   3060

ggcagcgcct ctaacctgtt caagaccatc gaggacaaca gcagggcaca gcagaaactc   3120

ttccgcgggg acaacctaga aaaagtgccc catttccagg tgagagacat cagagacaag   3180

tccaaggctc aaggccccct ccaccaggtg agagatgtca ggaaactaat taaagggtca   3240

ggggatagta gtgacaaggg cagtgttacc ccagagcagg ggctgactgg acccaaaccc   3300

aggcagctgt ctgcagcagc tggcggatct ggatccctgt cccccatggt gattacatgc   3360

caggctgtag tgaaccagag ggaagacagc atggaccgag agcccaggga aagcatgggc   3420

aaagggggcg gcagcagagt cttgaattct tcctccccag aagggacagt cttggttcac   3480

agggcatctg gcaggctgcc tgtggctacc attgccccca ataagcccga gcagggctca   3540

tacctgcctg tgctcaagat tgtctccaag gcttccaccc agaagacccc agagaagctc   3600

aaggaggagg aggtcaagga ggaagggaaa gccacgaagc cagcccggaa tgccctggag   3660

aagctgactg cagccgtgag gtccatggaa gagctgtaca gcttcaacag gaacgagtgg   3720

aagcgcaaaa gcgacccctt gcctatgatg atggacagcc acgtgctgtc gctcattgcc   3780

agtgaggaga gggaaggggt agtggttgct gatggagacc acgacaagct gtccaaacgg   3840

ctgggtgagg tggaagagcg gggcacagga aacaaagctg gtgtggtcct gcgaggggcc   3900

cccatagaac gtctgcagcg gagaaactcc aaccccagcg ctgagagtgt gtctgccagg   3960

gcagcggcct ttgagaacct ggccagggaa agaccccgat ctctctatat tcccccagtc   4020

cacaaggatg tagagagaac ccaacccctg cagcccctcc caccactccc cagcaaccgg   4080

aacgtgttca cagtgagtgc cagcagcatc cagaaaactg ggggtgtcgc tggcaagttc   4140

ccacaagggc cttctccgga gagtccttca gcagctaagg gcatcaagtc gcagggactc   4200

cggtccctca agatctctcc agccacccgg gcacctcctg atgaggtgac caacaggaaa   4260

agtggcagca atttggagaa gagcaacagt gactgtgaga attacctgac catccctctt   4320

aaaggaagct ctgctgcagg ggagcttctt agcaggcctg gggcttccag ggaggggccc   4380

cccaactcct cagctgccac tctctgtagt ttacccccgc tgagtgcccg cagtcaggtc   4440

cccagtagct ccaaaggctc tcaggttagt ggaaccagcc gaccagcttg gcgtaccaaa   4500

cctgacaacc cccgggagac agtagctgcc cccccagggc cacagagccc cgagcatccc   4560

cccaccacca tctaccacca gccgccgctg cccttcaccc tacagggggc ccagcctcag   4620

gtcctctgct tctccccacc cagcatgcct gccccagcac ctgcagcctc agctcccgtc   4680

cccacagacc ccttccagca ggcacagcct caacagaccc agcgtaagat gctcctggat   4740

gtgacaacag gccagtacta tctggtggac acaccagtac agcccatgac ccggagactg   4800

tttgaccctg agacagggca gtatgtggat gtgcccatga cctcccagca gcaggctgtg   4860

gctcccatgt ccatctctgt gcctcccttg gccctgagtc ctggggctta tggacccacc   4920

tacatgattt accctgggtt tctgcctacc gtgctgccca ccaatgctct gcagcccaca   4980

ccaattgctc gcgctccaag aggaagtgag ctctccccaa tggtggcaga accttccagc   5040

aaagaggcag ctgcaacgtt caccgaggcc ccatacttca tggcttctgg tcagtctccg   5100

gcctcctcaa cctcctcagc cccagcagcc acatcccagc tcctaggggc caaggccttt   5160

gcccagctgc atggcaagcc tgtcatcagc attacttcgc agcccctggg gccacggatc   5220

attgctcccc cttcctttga tggcaccacc atgagctttg tggtagaaca cagatgatga   5280

gcagccacca ggaagcggaa tgaaaaactg ctggagcaag acaaaaagat ggactattct   5340

tctttaatct ggaatttgca ttgtaatagc actaagaatt atttcatctg aaaaacttct   5400

tccacatgtg ttattcttaa tttttgcttc ttataagcta agtgtgtaag tttctatatt   5460

tttctgaaca atcctcttaa ggcagttttt attttaattt tattaagttg attgaatggt   5520

tgcatttttt ccctttatga ctatttcttt ttatacttca acacaggata taagctttct   5580

attcacctcc ttcccccctg tacttgtgac tagacaaaca attcctttgt tcccattgtt   5640

cagtcaaaac ataccacaga atgggattga ttctgttgta aaccaagcta gtaaatgagt   5700

aatttggatc acgaatctcc ttatagtttc ttggaatata tcaagactag ctggctgagt   5760

tgtaatacgt atttaagttt tcactatgat ggtctgctct ttgaatcata tatcagccaa   5820

acctacccat tctcttggtt atgctctata tgttctttta ttaggtttgg catgatttca   5880

aatgtgattg tgaaaaatgg tggttgtaat gtttgtgctt tattttattt ttcccatttg   5940

tacaatgcca cgacactatt tgttgcctta aaatagaatg gcttgaaata ctggaaagcc   6000

aatgattgca tctaaaatta agtacttagt ctcagaaagg tataaaatat ctattttcct   6060

ttaagaatcc aattattttt gtgggtgcat aacatttttc ttttcttcaa taattccctc   6120

catagttgca tactcgtgtc tctcatggat tgtttagagt ctaaagagtg acccatttgg   6180

ggcagtagag tagaatatgg cactaattca gtggctctga ttcactccag ccctagcctc   6240

gctatcccaa taacagtaac ctagagttac agcacttgct ccttatgagg atgaggcagg   6300

tttgaagaga tgtcaagaat ccaaatcaca gaatctttta ttgacattta gtactgtctc   6360

agttgtaacc caattctgaa ggctatttga gtgagtgttc acagggagtc ttgaagactg   6420

gaagacttga ttgaacagat aaatatttag cttgtcataa taagtgtatc gatatatact   6480

tggcaaatgt tacattgaaa tattacttaa ttacttttta aaggaataat ttgaaggttt   6540

tcccaggatt tttttttaag aatctccttt tatttaccaa tttgtttaaa gataaagcat   6600

tctggtaatt ttttaaacac cctaatatta ttttaaacct cagcaatatt tgatttctgc   6660

ttaaattttc ttcataagcc acagaatttt atgctactca tgacaaaaag tgtgagtaaa   6720

aaactaggag actgagtttt gtatgattta tataatcttt ttactttgta gttatgcttc   6780

ccatctcaga ctcttaaaaa agacttaatt tcactttcag ggccttcctt taagggatct   6840

tactctgaaa aaaagttctc ttgggtatag ggaaaggttt gaggcgggaa tagtcagctc   6900

tgatcacgat tcaattgctt gttgtgctga tgagctatga aatgaagcta tagactttat   6960

gagacatgaa atatgaaaca tagtctctgt gtataaaaaa gatgcccttg tgccaaattc   7020

aagaaaaaga tatttcttta tcatagaggt cttcttaccc aggcacatca atcaattccc   7080

cccagaactt aaagtaagtt ttatccactg gggaacaaat cttatggcat cagagcttcc   7140

tcgttttcag gagagattgg ctgggtataa ggtaacttaa tattgaccca agaaagtaga   7200

atccctttca gaaatcttac acttatttta ctgaaagcag caccaagaaa cctccagtat   7260

ttgaatacac ctggtgaaac ctatatagga tttgggtgga tagtaccaaa attgttaaga   7320

ctggtttaaa gccaaatgcg actttcagga aaaaccagtg gccatgttga gtagtgactg   7380

ctcaccaact cttccaaaag agagacaact ccttctctag aaaatgtggt agagttgagg   7440

gcttgggacc cctaatctat gtatcagtgt ttctcaccag cagatttgag ttttaaattc   7500

tcacactgag gtaaattagg acacaaacta aggaaagaaa gaaaaagctt ttcatttgtt   7560

tgttctatac aagaggcttc accttttagg aagttgccaa ggacacagtg atgtccaagt   7620

ggctaaaaac gcaactttta aataatgttc tattaatatc atgtcatcta tcgataattt   7680

tatggttctc tatttcacca aatcatacaa agctgctagg ccattcacta cctccagtga   7740

tagggaaaaa atattttcac gggcatgagg taaatctcaa tcttgatttt tattgttttg   7800

tcatttcttg aggttgcatg aatatttgaa tgaagtgata tacccttcct tttatagctc   7860

aaggggaatc aaacaagagc ctatgaagcc ttctgaccca taaaactatt accctaataa   7920

tgtcccttta gttactgaac ttccctttta ttttttatta ctataaaacc attagtaaaa   7980

catttcctaa atagtgcctt gaacttgaat ctaatcagaa ttgcagagtc tggcttttat   8040

aatatcctct tagggttata tgtgtggctt agttttccag aagatccact ttttacttgt   8100

tgataaaatg gtcatatttg aaatatgtcc catttcaatc atttctggaa aactgaacac   8160

atgtgtaacc gtataaaaat ttaattcgcc ag                                 8192


<210>  932
<211>  1758
<212>  PRT
<213>  Homosapiens

<400>  932

Met Gly His Ala Ser Gly Ser His Phe Leu Ser Glu Ser Pro Ser Lys 
1               5                   10                  15      


Pro His Cys Thr Leu Glu Gly Lys Gly Thr Arg Leu His Lys Lys Gln 
            20                  25                  30          


His Met Leu Ser Phe His Phe Trp Lys Ser Arg Gly Gln Pro Thr Asp 
        35                  40                  45              


Ala Ala Ser Ser Val Ala Asp Gly Ile Gln Thr Pro Arg Cys Cys Arg 
    50                  55                  60                  


Arg Cys Gln Ala Asn Asn Trp Thr Gly Gln Leu Ser Tyr Arg Thr Leu 
65                  70                  75                  80  


Ala Thr Val Ser Ala Gly Ala Ala Ala Pro Gln Pro Gln Thr Thr Ser 
                85                  90                  95      


Thr Ala Ser Ser Arg Ser Leu Pro Thr Ser Leu Arg Leu Ala Ala Ala 
            100                 105                 110         


Pro Pro Gln Gly Leu Lys Asn Trp Glu Val Val Ala Ala Val Ala Ala 
        115                 120                 125             


Val Pro Thr Ala Leu Gly Pro Val Gln Ile Arg Gly Thr Leu Leu Arg 
    130                 135                 140                 


Ala Thr Leu Gln Pro Leu Arg Gly Gln Arg Arg Thr Gln Asp Phe Pro 
145                 150                 155                 160 


Ser Asp His His Cys Leu Phe Leu Ser Leu Lys Pro Gly Gln Gly Leu 
                165                 170                 175     


Ile Met Glu Ala Ala Pro Pro Glu Leu Asn Ser Lys Ala Arg Gln Ala 
            180                 185                 190         


Glu Val Gly Asp Gly Val Ser Ser Ala Gln Asp Ser Gln Glu Leu Lys 
        195                 200                 205             


Gln Gln Leu Trp Pro Leu Pro Lys Pro Ser Ala Ser Ser Gln Arg Glu 
    210                 215                 220                 


Ala Lys Tyr Val Asp Met Cys Ala Ser Ala Glu Val Gln Arg Glu Ser 
225                 230                 235                 240 


Pro Gln Thr Met Lys Leu Thr Leu Gly His Cys Pro Gly Gly Gln Arg 
                245                 250                 255     


Ala Ser Arg Ser Pro Lys Glu Lys Ala Gln Asp Glu Pro Ser Ser Lys 
            260                 265                 270         


Thr Pro Ser Pro Gln Asn Asn Pro Ala Ser Ser Gln Leu Ser Arg Ser 
        275                 280                 285             


Gln His Ser Ala Ser Glu Glu Gly Gly Asn Phe Ser Ser Ser Ser Ser 
    290                 295                 300                 


Ser Ser Pro Met Asn Lys Ala Glu Glu Asp Gly Leu Ser Lys Met Glu 
305                 310                 315                 320 


Asp Ser Thr Thr Ser Thr Gly Ala Leu Ala Thr Ser Ser Ser Ser Leu 
                325                 330                 335     


Gly Phe Glu Ser Glu Ser Gly Glu Ser Glu Gly Cys Gln Ala Gly Ser 
            340                 345                 350         


Arg Asp Pro Pro Lys Val Glu Glu Ala His Tyr Ile Thr Thr His Glu 
        355                 360                 365             


Ile Gln Leu Ser Glu Val Glu Gln Asp Met Asp Phe Asp Val Gly Leu 
    370                 375                 380                 


Ala Ser Arg Trp Asp Phe Glu Asp Asn Asn Val Ile Tyr Ser Phe Val 
385                 390                 395                 400 


Asp Tyr Ala Ser Phe Gly Gly Ser Asp Glu Thr Pro Gly Asp Ile Thr 
                405                 410                 415     


Ser Leu Thr Glu Glu Asp Asp Asp Asn Ser Cys Tyr Leu Ser Thr Thr 
            420                 425                 430         


Pro Ser Thr Asn Thr Thr Arg Thr Pro Ser Pro Thr Ser Ser Asp Leu 
        435                 440                 445             


Ala Arg Pro Asn Ala Gly Arg Ser Gly Arg Asp Thr Ser Ser Thr Glu 
    450                 455                 460                 


Ala Ala Ser Gly Ala Ala Ala Ala Ala Ala Ser Ser Cys Gly Ser Ala 
465                 470                 475                 480 


Ala Ser Gln Ile Leu Leu Ser Ile Lys Pro Ala Ser Arg Ala Ile Asn 
                485                 490                 495     


Glu Pro Ser Asn Val Arg Ala Lys Gln Asn Ile Ile Tyr Ala Ala Lys 
            500                 505                 510         


His Glu Gly Asp Met Ser Leu Arg Val Ser Thr Ala Ala Glu His Asn 
        515                 520                 525             


Ser Ser Ser Leu Lys Gln Asn Pro Ala Ala Ala Val Ala Gln Asp His 
    530                 535                 540                 


Ala Lys Lys Phe Ile Ala Val Pro Ala Arg Leu Gln Thr Arg Cys Gly 
545                 550                 555                 560 


Ala Ile Arg Ala Lys Glu Leu Val Asp Tyr Ser Ser Gly Ala Ser Ser 
                565                 570                 575     


Ala Val Ser Glu Leu Asp Asp Ala Asp Lys Glu Val Arg Asn Leu Thr 
            580                 585                 590         


Ser Arg Ala Phe Arg Ser Leu Ala Tyr Pro Tyr Phe Glu Ala Leu Asn 
        595                 600                 605             


Ile Ser Ser Arg Glu Ser Ser Thr Thr Leu Ser Glu Val Gly Phe Gly 
    610                 615                 620                 


Arg Trp Ser Thr Phe Leu Asp Leu Lys Cys Gly Gly Val Gly Ala Arg 
625                 630                 635                 640 


Val Glu Gln Ser Leu Leu Arg Ser Ser Ala Ala Ser Val Ala Ala Gly 
                645                 650                 655     


Leu Arg Lys Gly Ser Gly Ala Arg Ala Thr Ala Asp Gln Leu Tyr Ile 
            660                 665                 670         


Gln Ser Lys Lys Ser Gln Thr Lys Ala Leu Glu Phe Val Val Ser Lys 
        675                 680                 685             


Val Glu Gly Glu Ile Lys His Val Glu Thr Pro Leu Cys Phe Gln Lys 
    690                 695                 700                 


Gln Val Gln Thr Gly Ser Arg Val Val Thr Leu Leu Glu Pro Leu Asn 
705                 710                 715                 720 


Val Arg Ser Glu Ser Lys Ala Ser Ser Ala Pro Gly Pro Gly Arg Ala 
                725                 730                 735     


Thr Lys Gly Pro Gly Lys Gly Pro Gly Ser Ala Tyr Thr Asp Asp Gly 
            740                 745                 750         


Ser Glu Thr Ser Glu Gly Ser Lys Pro Thr Ser Arg Ala Asp Gly Pro 
        755                 760                 765             


Gln Lys Ser Lys Phe Ala Ser Ser Leu Leu Lys Asn Val Ile Ser Lys 
    770                 775                 780                 


Lys Met Gln Arg Glu His Glu Phe Lys Met Glu Arg Gly Glu Val Met 
785                 790                 795                 800 


Asp Thr Ser His His Leu Ser Gly Thr Ser Lys Glu Thr Glu Gly Ala 
                805                 810                 815     


Arg Gly Ser Glu Arg Gln Arg Glu Arg Gly Leu Gln Arg Gln Ser Ser 
            820                 825                 830         


Arg His Ser Glu Ala Gly Ser Glu Tyr Thr Val Val Ser Met Ser Asp 
        835                 840                 845             


Ala Gly Gly Glu Gly Ser Val Ala Gly Ser Lys Ser Pro Val Phe Lys 
    850                 855                 860                 


Ala Ser Thr Pro Arg Glu Arg Asn Ala Gly Pro Gly Arg Asn Phe Thr 
865                 870                 875                 880 


Asp Gly His Thr Glu Val Cys Glu Ile Lys Lys Ser Ala Ser Glu Thr 
                885                 890                 895     


Val Lys Gly Ile Phe Leu Arg Ser Gln Asn Ser Ala Phe Arg Ser Trp 
            900                 905                 910         


Lys Glu Lys Glu Ala Glu Lys Arg Glu Glu Gln Ala Pro Ile Gly Lys 
        915                 920                 925             


Leu Lys Leu Pro Lys Gly Gly Asp Trp Arg Ala Asp Leu Gly Glu Ile 
    930                 935                 940                 


Ser Ala Ser Lys Asn Thr Ile Met Ser Arg Leu Phe Val Pro Asn Ile 
945                 950                 955                 960 


Gln Gln Thr Pro Lys Asp Lys Gln Pro Arg Lys Gln Ala Thr Lys Tyr 
                965                 970                 975     


Pro Ala Ala Gln Ala Thr Ser Thr Ala Val Ile Arg Pro Lys Ala Pro 
            980                 985                 990         


Glu Ile Lys Ile Arg Leu Gly Ser  Val Gln Gln Pro Ser  Ser Asp Phe 
        995                 1000                 1005             


Asn Ile  Ala Lys Leu Leu Thr  Pro Lys Leu Ala Gly  Gly Ser Ala 
    1010                 1015                 1020             


Ser Asn  Leu Phe Lys Thr Ile  Glu Asp Asn Ser Arg  Ala Gln Gln 
    1025                 1030                 1035             


Lys Leu  Phe Arg Gly Asp Asn  Leu Glu Lys Val Pro  His Phe Gln 
    1040                 1045                 1050             


Val Arg  Asp Ile Arg Asp Lys  Ser Lys Ala Gln Gly  Pro Leu His 
    1055                 1060                 1065             


Gln Val  Arg Asp Val Arg Lys  Leu Ile Lys Gly Ser  Gly Asp Ser 
    1070                 1075                 1080             


Ser Asp  Lys Gly Ser Val Thr  Pro Glu Gln Gly Leu  Thr Gly Pro 
    1085                 1090                 1095             


Lys Pro  Arg Gln Leu Ser Ala  Ala Ala Gly Gly Ser  Gly Ser Leu 
    1100                 1105                 1110             


Ser Pro  Met Val Ile Thr Cys  Gln Ala Val Val Asn  Gln Arg Glu 
    1115                 1120                 1125             


Asp Ser  Met Asp Arg Glu Pro  Arg Glu Ser Met Gly  Lys Gly Gly 
    1130                 1135                 1140             


Gly Ser  Arg Val Leu Asn Ser  Ser Ser Pro Glu Gly  Thr Val Leu 
    1145                 1150                 1155             


Val His  Arg Ala Ser Gly Arg  Leu Pro Val Ala Thr  Ile Ala Pro 
    1160                 1165                 1170             


Asn Lys  Pro Glu Gln Gly Ser  Tyr Leu Pro Val Leu  Lys Ile Val 
    1175                 1180                 1185             


Ser Lys  Ala Ser Thr Gln Lys  Thr Pro Glu Lys Leu  Lys Glu Glu 
    1190                 1195                 1200             


Glu Val  Lys Glu Glu Gly Lys  Ala Thr Lys Pro Ala  Arg Asn Ala 
    1205                 1210                 1215             


Leu Glu  Lys Leu Thr Ala Ala  Val Arg Ser Met Glu  Glu Leu Tyr 
    1220                 1225                 1230             


Ser Phe  Asn Arg Asn Glu Trp  Lys Arg Lys Ser Asp  Pro Leu Pro 
    1235                 1240                 1245             


Met Met  Met Asp Ser His Val  Leu Ser Leu Ile Ala  Ser Glu Glu 
    1250                 1255                 1260             


Arg Glu  Gly Val Val Val Ala  Asp Gly Asp His Asp  Lys Leu Ser 
    1265                 1270                 1275             


Lys Arg  Leu Gly Glu Val Glu  Glu Arg Gly Thr Gly  Asn Lys Ala 
    1280                 1285                 1290             


Gly Val  Val Leu Arg Gly Ala  Pro Ile Glu Arg Leu  Gln Arg Arg 
    1295                 1300                 1305             


Asn Ser  Asn Pro Ser Ala Glu  Ser Val Ser Ala Arg  Ala Ala Ala 
    1310                 1315                 1320             


Phe Glu  Asn Leu Ala Arg Glu  Arg Pro Arg Ser Leu  Tyr Ile Pro 
    1325                 1330                 1335             


Pro Val  His Lys Asp Val Glu  Arg Thr Gln Pro Leu  Gln Pro Leu 
    1340                 1345                 1350             


Pro Pro  Leu Pro Ser Asn Arg  Asn Val Phe Thr Val  Ser Ala Ser 
    1355                 1360                 1365             


Ser Ile  Gln Lys Thr Gly Gly  Val Ala Gly Lys Phe  Pro Gln Gly 
    1370                 1375                 1380             


Pro Ser  Pro Glu Ser Pro Ser  Ala Ala Lys Gly Ile  Lys Ser Gln 
    1385                 1390                 1395             


Gly Leu  Arg Ser Leu Lys Ile  Ser Pro Ala Thr Arg  Ala Pro Pro 
    1400                 1405                 1410             


Asp Glu  Val Thr Asn Arg Lys  Ser Gly Ser Asn Leu  Glu Lys Ser 
    1415                 1420                 1425             


Asn Ser  Asp Cys Glu Asn Tyr  Leu Thr Ile Pro Leu  Lys Gly Ser 
    1430                 1435                 1440             


Ser Ala  Ala Gly Glu Leu Leu  Ser Arg Pro Gly Ala  Ser Arg Glu 
    1445                 1450                 1455             


Gly Pro  Pro Asn Ser Ser Ala  Ala Thr Leu Cys Ser  Leu Pro Pro 
    1460                 1465                 1470             


Leu Ser  Ala Arg Ser Gln Val  Pro Ser Ser Ser Lys  Gly Ser Gln 
    1475                 1480                 1485             


Val Ser  Gly Thr Ser Arg Pro  Ala Trp Arg Thr Lys  Pro Asp Asn 
    1490                 1495                 1500             


Pro Arg  Glu Thr Val Ala Ala  Pro Pro Gly Pro Gln  Ser Pro Glu 
    1505                 1510                 1515             


His Pro  Pro Thr Thr Ile Tyr  His Gln Pro Pro Leu  Pro Phe Thr 
    1520                 1525                 1530             


Leu Gln  Gly Ala Gln Pro Gln  Val Leu Cys Phe Ser  Pro Pro Ser 
    1535                 1540                 1545             


Met Pro  Ala Pro Ala Pro Ala  Ala Ser Ala Pro Val  Pro Thr Asp 
    1550                 1555                 1560             


Pro Phe  Gln Gln Ala Gln Pro  Gln Gln Thr Gln Arg  Lys Met Leu 
    1565                 1570                 1575             


Leu Asp  Val Thr Thr Gly Gln  Tyr Tyr Leu Val Asp  Thr Pro Val 
    1580                 1585                 1590             


Gln Pro  Met Thr Arg Arg Leu  Phe Asp Pro Glu Thr  Gly Gln Tyr 
    1595                 1600                 1605             


Val Asp  Val Pro Met Thr Ser  Gln Gln Gln Ala Val  Ala Pro Met 
    1610                 1615                 1620             


Ser Ile  Ser Val Pro Pro Leu  Ala Leu Ser Pro Gly  Ala Tyr Gly 
    1625                 1630                 1635             


Pro Thr  Tyr Met Ile Tyr Pro  Gly Phe Leu Pro Thr  Val Leu Pro 
    1640                 1645                 1650             


Thr Asn  Ala Leu Gln Pro Thr  Pro Ile Ala Arg Ala  Pro Arg Gly 
    1655                 1660                 1665             


Ser Glu  Leu Ser Pro Met Val  Ala Glu Pro Ser Ser  Lys Glu Ala 
    1670                 1675                 1680             


Ala Ala  Thr Phe Thr Glu Ala  Pro Tyr Phe Met Ala  Ser Gly Gln 
    1685                 1690                 1695             


Ser Pro  Ala Ser Ser Thr Ser  Ser Ala Pro Ala Ala  Thr Ser Gln 
    1700                 1705                 1710             


Leu Leu  Gly Ala Lys Ala Phe  Ala Gln Leu His Gly  Lys Pro Val 
    1715                 1720                 1725             


Ile Ser  Ile Thr Ser Gln Pro  Leu Gly Pro Arg Ile  Ile Ala Pro 
    1730                 1735                 1740             


Pro Ser  Phe Asp Gly Thr Thr  Met Ser Phe Val Val  Glu His Arg 
    1745                 1750                 1755             


<210>  933
<211>  2950
<212>  DNA
<213>  Homosapiens

<400>  933
gcaggctgct gtctcacaga gcgagaaggt gtcaggagca gcccagttgt gtctctctct     60

ctacctctgt gaagggcgcg aatgggcaga gcagaacttc tagaagggaa gatgagcacc    120

caggatccct cagatctgtg gagcagatcc gatggagagg ctgagctgct ccaggacttg    180

gggtggtatc acggcaacct cacacgccat gctgctgaag ctcttctcct ctcaaatgga    240

tgtgacggca gctaccttct gagggacagc aatgagacca ccgggctgta ctctctctct    300

gtgagggcca aagattctgt taaacacttt catgttgaat atactggata ttcatttaaa    360

tttggcttta atgaattctc atctttgaag gattttgtca agcattttgc aaatcagcct    420

ttgattggaa gcgagacagg cactctgatg gttctaaaac atccctaccc aagaaaagtg    480

gaagaaccct ccatttatga atctgtccgg gttcacacag caatgcagac aggaagaaca    540

gaagatgacc ttgtgcccac agcaccttct ctgggcacca aagaaggtta cctcaccaaa    600

cagggaggcc tggtcaagac ctggaaaaca agatggttta ctctgcacag gaatgaactg    660

aaatacttca aagaccagat gtcaccagaa ccaattcgga tcctagacct aacagaatgt    720

tcagctgtac aattcgatta ttcacaagaa agggtaaact gtttttgttt ggtatttcca    780

ttcaggacat tttatctctg tgcaaagacc ggagtagaag ctgatgagtg gatcaagata    840

ttacgctgga aattggtcaa ggacaaaagc tgtattttgt ctgctctctg tatatctccc    900

gaggagaaga ctgatcacaa ataagaaaac agctcaacca aggggaaggc acgatccgat    960

ctcggtcgtt catctttaaa tagatctttc ttgccaagga atgctctggc ccaggagcaa   1020

ggtggaatgt ttccctgacg ctgtgatctg cagcaggctt caaatgaaaa ccgactaagg   1080

attttctttc aaaaacaaat cagaagcaga tgctgattgg gacccatata ccacgttgct   1140

gactcacgtt gctgcccttc catgatgttg ccatctcctt gagaacactg aagcaatcac   1200

cattctgata gaaagtgctt aaaccaccac tcttaggtct gctcactctt agaacacaca   1260

atggaagagg aagggttttt gttttcactc attgtggtcc ccaagcctat tgacactagt   1320

tgcctagagt cccactgtga gtcatggtca gcctgtctga catccaggtt gtgctattaa   1380

ccaagaagga aacagatact tggaggctta gatgacttct gcaggattta tattcagata   1440

gaaaacatca aatattttca ggggagaggt tttttttttt aatttttccc cctttataca   1500

aaaaaaaaga acatttccaa aactaaaata gaaaatgctt gtggcattta ttttctcttt   1560

ttaaaaggtt cagaaatttg gcaggtcctt tgcttctaat gacaaaactg tgagagctag   1620

atgtcctatg ggcaattagg tagtataata aaggtaaatg aaggtacaat ttttaaacca   1680

ttattttcac cctgttgggg taaatgtttt aaagagtgag aaaacataaa ttgagaaagg   1740

gtgataaagt aatagataac ttttagttta ataataatta ttgttattat actactaata   1800

atagagcact tgtaagcact aagttatctt tatccaacat ttctccaaat ggactgaaag   1860

aaacttttca aggacagtgt attataacaa tccctttccc agaattagtt gtatagggtt   1920

ggcccaagag atgtaagaaa aatctcgcat tgctccctaa gcaccctggg ccttattaaa   1980

gagcaacttc tatttccagt cgggggagta acactaaagc tacaagaaat atgtaataat   2040

gataggtaat aatgtgttcc aaagcttttt caaactagaa taaggaggca aatagaagaa   2100

tgagatactg atgtccacag ttcattggca gaatctaacc ccttctgtta tcttttttaa   2160

tactattttt gtttagatag aagtttcaaa gaagataaaa atgcttgaag agcctgagag   2220

taaaaagatt atgctgcaaa gctatgatat aaactgctct tgcagtccaa agggatacct   2280

gattaaagaa gtttcttatt taaacatctc agacgcaaaa attacattaa atttttgtat   2340

atttcaacaa cattttaaat gtattttgtt atgtttgtat tatataggat aaagcaaatg   2400

tcaagttaaa atgtattgtg ttgtttgtaa agtaagaagt tactggccag gagcggcggc   2460

tcatgcctgt aatcccagga ctttggtagg ccaagacaag cagatcactt gaggtcagga   2520

gttcaacatc agcctggcca acatgatgaa accttgtctt tactaaaaat acaaaaatta   2580

gctgggcatg gtggcaggcg cctgtaatcc cagctactca ggaggctgag gcaggagaat   2640

tgcttgaacc cgggaggtgg aggttgcagt gaaccaagat cgcggcgctg cactctagcc   2700

tgggtgacag agtcagactc cgtcccaaaa aaacaaacaa acaaaacaaa acaaaaaaaa   2760

cagaagttac aaatgaatac tcacggatat gtatagtttt atgtttgttt tcttagaaac   2820

aaatgtgttt ctttgggtgg gtaatattgt gttttactat gtttaccttt tataaaacat   2880

aacctgttta tttatattct ttggctttgt ttattaaaaa gcatgatttt gctgtgcatg   2940

taccattttg                                                          2950


<210>  934
<211>  280
<212>  PRT
<213>  Homosapiens

<400>  934

Met Gly Arg Ala Glu Leu Leu Glu Gly Lys Met Ser Thr Gln Asp Pro 
1               5                   10                  15      


Ser Asp Leu Trp Ser Arg Ser Asp Gly Glu Ala Glu Leu Leu Gln Asp 
            20                  25                  30          


Leu Gly Trp Tyr His Gly Asn Leu Thr Arg His Ala Ala Glu Ala Leu 
        35                  40                  45              


Leu Leu Ser Asn Gly Cys Asp Gly Ser Tyr Leu Leu Arg Asp Ser Asn 
    50                  55                  60                  


Glu Thr Thr Gly Leu Tyr Ser Leu Ser Val Arg Ala Lys Asp Ser Val 
65                  70                  75                  80  


Lys His Phe His Val Glu Tyr Thr Gly Tyr Ser Phe Lys Phe Gly Phe 
                85                  90                  95      


Asn Glu Phe Ser Ser Leu Lys Asp Phe Val Lys His Phe Ala Asn Gln 
            100                 105                 110         


Pro Leu Ile Gly Ser Glu Thr Gly Thr Leu Met Val Leu Lys His Pro 
        115                 120                 125             


Tyr Pro Arg Lys Val Glu Glu Pro Ser Ile Tyr Glu Ser Val Arg Val 
    130                 135                 140                 


His Thr Ala Met Gln Thr Gly Arg Thr Glu Asp Asp Leu Val Pro Thr 
145                 150                 155                 160 


Ala Pro Ser Leu Gly Thr Lys Glu Gly Tyr Leu Thr Lys Gln Gly Gly 
                165                 170                 175     


Leu Val Lys Thr Trp Lys Thr Arg Trp Phe Thr Leu His Arg Asn Glu 
            180                 185                 190         


Leu Lys Tyr Phe Lys Asp Gln Met Ser Pro Glu Pro Ile Arg Ile Leu 
        195                 200                 205             


Asp Leu Thr Glu Cys Ser Ala Val Gln Phe Asp Tyr Ser Gln Glu Arg 
    210                 215                 220                 


Val Asn Cys Phe Cys Leu Val Phe Pro Phe Arg Thr Phe Tyr Leu Cys 
225                 230                 235                 240 


Ala Lys Thr Gly Val Glu Ala Asp Glu Trp Ile Lys Ile Leu Arg Trp 
                245                 250                 255     


Lys Leu Val Lys Asp Lys Ser Cys Ile Leu Ser Ala Leu Cys Ile Ser 
            260                 265                 270         


Pro Glu Glu Lys Thr Asp His Lys 
        275                 280 


<210>  935
<211>  2085
<212>  DNA
<213>  Homosapiens

<400>  935
atgctcagct cagctcggcc ctcgcctttg atttattttt tttctgggcg gccgctgcga     60

cccgggactg acttcgggat gggaagtgga gcccccggag ctgctaccgt ggcggcggcg    120

ctgtgaggag cagccagggg gaggcagctg cggctcgccg gtgagtatcc gggaagcgcc    180

accatggggc tccgtaagaa gagcaccaag aacccccccg ttctcagcca ggaattcatc    240

ctgcagaatc atgcggacat cgtctcctgc gtggggatgt tcttcctgct ggggcttgtg    300

ttcgagggaa cagcagaagc atccatcgtg tttctcactc ttcagcacag tgttgctgcc    360

cctgcagcag aggaacaagc cacgggctca aagtccctct attattatgg tgtcaaagat    420

ttggccacgg ttttcttcta catgctggtg gcaatcatta ttcatgccac aattcaggaa    480

tatgtgttgg ataaaattaa caagagaatg cagttcacca aagcgaaaca aaacaagttt    540

aacgagtctg gtcagtttag tgtgttctac tttttttctt gtatttgggg cacattcatt    600

ttaatctctg aaaactgcct gtcagaccca actcttatat ggaaggctcg tccccatagc    660

atgatgacat ttcaaatgaa gtttttctac atatcccagt tggcttactg gtttcatgct    720

tttcctgaac tctacttcca gaaaaccaaa aaacaagaca tccctcgtca acttgtctac    780

attggtcttc acctcttcca cattactgga gcttatctct tgtacttgaa tcatttggga    840

cttcttcttt tggtactgca ttattttgtt gaattacttt cccacatgtg cggcctgttt    900

tactttagtg atgagaagta ccagaaaggc atatctctgt gggccattgt gtttatcttg    960

ggtagacttg tgactttaat tgtttccgta ctcactgttg ggtttcacct ggctggatcg   1020

cagaatcgga atcctgatgc ccttactgga aatgtaaatg tgttggcagc taaaattgct   1080

gttctgtcgt ccagttgcac gatccaagcc tacgtaacat ggaacttaat tactctctgg   1140

cttcagaggt gggtagaaga ttctaatatt caggcctcat gtatgaaaaa gaaacggtcg   1200

agatcttcta aaaaaagaac agaaaacgga gtgggagtgg aaacttcaaa tagagtagac   1260

tgtccgccaa agaggaaaga gaaatcttca taatctttgc aagcgcattg attaatgtct   1320

gcaaaggaat ctgctctttg aggtttcttt ctgcactaga gatttttctg tttttgaaaa   1380

tagttcgtgc tcttcggttt ttgttattga actgtttcat gtatttttta aagacatttg   1440

aggggaggag gattattatg aatgggaaaa aaagattttg gttgagacta aattactcat   1500

cgtcaaaata atgtcaaaat agttttgggg atcaccacta tattttgttt tgatttttaa   1560

cctttcaaca ttttcctaat gatttgcaga gataactgca caattttgca tatcaatgat   1620

actggttctt actcccacca gtgtttcata atactaacaa gatggtctct cctagcaaga   1680

ttatgtgttt aatgcttgct ttggggtaaa ataaaagtac gaaaaaggtg gaagtcaaat   1740

cagtattctg taattgttag aatttatttt ttaagaactt acaactcaga aaagattgct   1800

agactcacca aaataataaa tgttctttat tttacaggta gtgattatta gtgcttcatc   1860

cccatttaaa aaaacacagt actaatgggt aacacatatg gaggtttgct gccatatata   1920

ttgtatcaaa atatcattaa ttaatataaa aatattaaaa tcattcctgt ccattccact   1980

tgtaaatggg aattcatgaa attaaatatt actttaaaaa ggaaaaaaaa aaaaaaaaaa   2040

aagaaaaaaa aaaaaaaaaa aaaaaaaaca aaaaaaaaaa aaaaa                   2085


<210>  936
<211>  369
<212>  PRT
<213>  Homosapiens

<400>  936

Met Gly Leu Arg Lys Lys Ser Thr Lys Asn Pro Pro Val Leu Ser Gln 
1               5                   10                  15      


Glu Phe Ile Leu Gln Asn His Ala Asp Ile Val Ser Cys Val Gly Met 
            20                  25                  30          


Phe Phe Leu Leu Gly Leu Val Phe Glu Gly Thr Ala Glu Ala Ser Ile 
        35                  40                  45              


Val Phe Leu Thr Leu Gln His Ser Val Ala Ala Pro Ala Ala Glu Glu 
    50                  55                  60                  


Gln Ala Thr Gly Ser Lys Ser Leu Tyr Tyr Tyr Gly Val Lys Asp Leu 
65                  70                  75                  80  


Ala Thr Val Phe Phe Tyr Met Leu Val Ala Ile Ile Ile His Ala Thr 
                85                  90                  95      


Ile Gln Glu Tyr Val Leu Asp Lys Ile Asn Lys Arg Met Gln Phe Thr 
            100                 105                 110         


Lys Ala Lys Gln Asn Lys Phe Asn Glu Ser Gly Gln Phe Ser Val Phe 
        115                 120                 125             


Tyr Phe Phe Ser Cys Ile Trp Gly Thr Phe Ile Leu Ile Ser Glu Asn 
    130                 135                 140                 


Cys Leu Ser Asp Pro Thr Leu Ile Trp Lys Ala Arg Pro His Ser Met 
145                 150                 155                 160 


Met Thr Phe Gln Met Lys Phe Phe Tyr Ile Ser Gln Leu Ala Tyr Trp 
                165                 170                 175     


Phe His Ala Phe Pro Glu Leu Tyr Phe Gln Lys Thr Lys Lys Gln Asp 
            180                 185                 190         


Ile Pro Arg Gln Leu Val Tyr Ile Gly Leu His Leu Phe His Ile Thr 
        195                 200                 205             


Gly Ala Tyr Leu Leu Tyr Leu Asn His Leu Gly Leu Leu Leu Leu Val 
    210                 215                 220                 


Leu His Tyr Phe Val Glu Leu Leu Ser His Met Cys Gly Leu Phe Tyr 
225                 230                 235                 240 


Phe Ser Asp Glu Lys Tyr Gln Lys Gly Ile Ser Leu Trp Ala Ile Val 
                245                 250                 255     


Phe Ile Leu Gly Arg Leu Val Thr Leu Ile Val Ser Val Leu Thr Val 
            260                 265                 270         


Gly Phe His Leu Ala Gly Ser Gln Asn Arg Asn Pro Asp Ala Leu Thr 
        275                 280                 285             


Gly Asn Val Asn Val Leu Ala Ala Lys Ile Ala Val Leu Ser Ser Ser 
    290                 295                 300                 


Cys Thr Ile Gln Ala Tyr Val Thr Trp Asn Leu Ile Thr Leu Trp Leu 
305                 310                 315                 320 


Gln Arg Trp Val Glu Asp Ser Asn Ile Gln Ala Ser Cys Met Lys Lys 
                325                 330                 335     


Lys Arg Ser Arg Ser Ser Lys Lys Arg Thr Glu Asn Gly Val Gly Val 
            340                 345                 350         


Glu Thr Ser Asn Arg Val Asp Cys Pro Pro Lys Arg Lys Glu Lys Ser 
        355                 360                 365             


Ser 
    


<210>  937
<211>  2126
<212>  DNA
<213>  Homosapiens

<400>  937
gaagaagcaa tcagaagatt ggcaggattt aggaatctat ttgaaatatt cattacctat     60

tttgaattgg tcttaaaaat ttaaagaaat ataaagctgg ataattaaag ataaataata    120

aaggaagaat acaaggtttc tatgctgtga agcaactgag attattatga ttttggggca    180

gtgaatttgt ttctagaagt tttgttggaa ctaaggcaga aaggaagaag aacaaatgac    240

cttggaatga aaaactttaa gttactccac ctaaccacta tgaatgatag tcttgtctca    300

ccaaccccag cccatcatct gttggacttg gagctcacac tttaaaaaag aagatcattc    360

taactgcccc tcatgactac tgaagaggct atgcctgaaa aagcaaaatg tcctacatta    420

gagatcacca agcaagactt ttttcaagaa gcaaaaactc tcattgccca acattatgag    480

aaaataaatg agaataaagt tcaaggtact tctataaatg tttttagaaa gaaacaccaa    540

aaaccgaaat ctggcaaata catacctttg gagattgaca aaaaggtaac acgtgatgtg    600

gtgcaagaac atcgggccgc actcagaagg atttgctttc ccaaggagct ttccaaaagc    660

gagcatcttc aggaaccccc acaacgaatc tccttcaagg aaccacacat ttttagtaga    720

agagaaagat gcaggcccat agatctaatt acaaaaggta tgtagtgaac ctgttccctg    780

ctcatgtatt caattccaag tgtattcaga tgacaagtta aattggataa aatcatgact    840

attattgaac cagtgagtaa aaaaatggag acagcaaagc aacagcactt tgaggagtcc    900

agaaacagaa tgttggaatt actctatccc tttcctgtcc atctttactt acaacctggg    960

acctctaact tggaacttct gaaagaacct gacaaagcat tctatgactg gagaggattt   1020

gtgctgacaa ggtctttccg tttggcttgt gactcccgtc gagttagttt ctctcaatca   1080

tcatcaatat ttcgggatta ttattctaaa acctttaaaa cccttattaa aaaggagcga   1140

caacctatca agccagaacc aaaatcacaa cccaggataa aaggtactcc aaataaaact   1200

gataaacttg acagtaaagt taaaagaatt ggaccacaca tagaaatctt ccaagtgttc   1260

cgagaaagaa aaaaattcat gattacccca aaattgatta gaatggtcac cgtcatgcag   1320

gcacatgtca ggggatggct tgaacggaaa agattgcaaa gagtaatgac caaggctttg   1380

gatcatggac cagatatgaa agcagttatt aacatgtatg gcagactaat ccaccgtgtt   1440

agatatcgac gtggtctttg gaggacaaga caaattctca acttagcaga gctagaggag   1500

tggatggacc gaaaaaaatt ctatgaaata atgtttgcta agagggaaga ttggccaaaa   1560

attgaaagaa atgagctccc caatttcttc agtgactgtg gtcatttccc aactcagaaa   1620

caagttgatg atacttggga cctggtccat caagacacac ccaggatcaa tattttgcat   1680

ccttcaatcc aatcgagttg acactcagta ttaaccatca caagctccaa gaaggttaag   1740

agacattaac agactgaaaa acaacctgca gcgtatagct gcccagctat gcccagccta   1800

gaccagatga accccacctg actcacatga gctaactaaa tgtttatcat tgatatgata   1860

aacacatatg agatggcaaa gaaaaatatt ctgaactaat caaaaagtcc aaagcaattg   1920

aaatgttatt tacactctat cctcctgaag gtgcacatgt gcctgacagt acactactca   1980

agtcgacttg gttgagaccc atagtaaatg gggaagaagg ttatagatat atagttttcc   2040

acctgaaatt atcagaaggt gacctatatc tatttgtgtt tgttgtttag agtctatttg   2100

cactttgtta aaataaacaa attaaa                                        2126


<210>  938
<211>  288
<212>  PRT
<213>  Homosapiens

<400>  938

Met Thr Ile Ile Glu Pro Val Ser Lys Lys Met Glu Thr Ala Lys Gln 
1               5                   10                  15      


Gln His Phe Glu Glu Ser Arg Asn Arg Met Leu Glu Leu Leu Tyr Pro 
            20                  25                  30          


Phe Pro Val His Leu Tyr Leu Gln Pro Gly Thr Ser Asn Leu Glu Leu 
        35                  40                  45              


Leu Lys Glu Pro Asp Lys Ala Phe Tyr Asp Trp Arg Gly Phe Val Leu 
    50                  55                  60                  


Thr Arg Ser Phe Arg Leu Ala Cys Asp Ser Arg Arg Val Ser Phe Ser 
65                  70                  75                  80  


Gln Ser Ser Ser Ile Phe Arg Asp Tyr Tyr Ser Lys Thr Phe Lys Thr 
                85                  90                  95      


Leu Ile Lys Lys Glu Arg Gln Pro Ile Lys Pro Glu Pro Lys Ser Gln 
            100                 105                 110         


Pro Arg Ile Lys Gly Thr Pro Asn Lys Thr Asp Lys Leu Asp Ser Lys 
        115                 120                 125             


Val Lys Arg Ile Gly Pro His Ile Glu Ile Phe Gln Val Phe Arg Glu 
    130                 135                 140                 


Arg Lys Lys Phe Met Ile Thr Pro Lys Leu Ile Arg Met Val Thr Val 
145                 150                 155                 160 


Met Gln Ala His Val Arg Gly Trp Leu Glu Arg Lys Arg Leu Gln Arg 
                165                 170                 175     


Val Met Thr Lys Ala Leu Asp His Gly Pro Asp Met Lys Ala Val Ile 
            180                 185                 190         


Asn Met Tyr Gly Arg Leu Ile His Arg Val Arg Tyr Arg Arg Gly Leu 
        195                 200                 205             


Trp Arg Thr Arg Gln Ile Leu Asn Leu Ala Glu Leu Glu Glu Trp Met 
    210                 215                 220                 


Asp Arg Lys Lys Phe Tyr Glu Ile Met Phe Ala Lys Arg Glu Asp Trp 
225                 230                 235                 240 


Pro Lys Ile Glu Arg Asn Glu Leu Pro Asn Phe Phe Ser Asp Cys Gly 
                245                 250                 255     


His Phe Pro Thr Gln Lys Gln Val Asp Asp Thr Trp Asp Leu Val His 
            260                 265                 270         


Gln Asp Thr Pro Arg Ile Asn Ile Leu His Pro Ser Ile Gln Ser Ser 
        275                 280                 285             


<210>  939
<211>  3570
<212>  DNA
<213>  Homosapiens

<400>  939
agacaggtca ggacatttgg taggggaagg ttgaaagaca aaagcagcag gccttgggtt     60

ctcagccttt taaaaactat tattaaatat atatttttaa aatttagtgg ttagagcttt    120

tagtaatgtg cctgtattac atgtagagag tattcgtcaa ccaagaggag ttttaaaatg    180

tcaaaaccgg gaaaacctac tctaaaccat ggcttggttc ctgttgatct taaaagtgca    240

aaagagcctc taccacatca aactgtgatg aagatattta gcattagcat cattgcccaa    300

ggcctccctt tttgtcgaag acggatgaaa agaaagttgg accatggttc tgaggtccgc    360

tctttttctt tgggaaagaa accatgcaaa gtctcagaat atacaagtac cactgggctt    420

gtaccatgtt cagcaacacc aacaactttt ggggacctca gagcagccaa tggccaaggg    480

caacaacgac gccgaattac atctgtccag ccacctacag gcctccagga atggctaaaa    540

atgtttcaga gctggagtgg accagagaaa ttgcttgctt tagatgaact cattgatagt    600

tgtgaaccaa cacaagtaaa acatatgatg caagtgatag aaccccagtt tcaacgagac    660

ttcatttcat tgctccctaa agagttggca ctctatgtgc tttcattcct ggaacccaaa    720

gacctgctac aagcagctca gacatgtcgc tactggagaa ttttggctga agacaacctt    780

ctctggagag agaaatgcaa agaagagggg attgatgaac cattgcacat caagagaaga    840

aaagtaataa aaccaggttt catacacagt ccatggaaaa gtgcatacat cagacagcac    900

agaattgata ctaactggag gcgaggagaa ctcaaatctc ctaaggtgct gaaaggacat    960

gatgatcatg tgatcacatg cttacagttt tgtggtaacc gaatagttag tggttctgat   1020

gacaacactt taaaagtttg gtcagcagtc acaggcaaat gtctgagaac attagtggga   1080

catacaggtg gagtatggtc atcacaaatg agagacaaca tcatcattag tggatctaca   1140

gatcggacac tcaaagtgtg gaatgcagag actggagaat gtatacacac cttatatggg   1200

catacttcca ctgtgcgttg tatgcatctt catgaaaaaa gagttgttag cggttctcga   1260

gatgccactc ttagggtttg ggatattgag acaggccagt gtttacatgt tttgatgggt   1320

catgttgcag cagtccgctg tgttcaatat gatggcagga gggttgttag tggagcatat   1380

gattttatgg taaaggtgtg ggatccagag actgaaacct gtctacacac gttgcagggg   1440

catactaata gagtctattc attacagttt gatggtatcc atgtggtgag tggatctctt   1500

gatacatcaa tccgtgtttg ggatgtggag acagggaatt gcattcacac gttaacaggg   1560

caccagtcgt taacaagtgg aatggaactc aaagacaata ttcttgtctc tgggaatgca   1620

gattctacag ttaaaatctg ggatatcaaa acaggacagt gtttacaaac attgcaaggt   1680

cccaacaagc atcagagtgc tgtgacctgt ttacagttca acaagaactt tgtaattacc   1740

agctcagatg atggaactgt aaaactatgg gacttgaaaa cgggtgaatt tattcgaaac   1800

ctagtcacat tggagagtgg ggggagtggg ggagttgtgt ggcggatcag agcctcaaac   1860

acaaagctgg tgtgtgcagt tgggagtcgg aatgggactg aagaaaccaa gctgctggtg   1920

ctggactttg atgtggacat gaagtgaaga gcagaaaaga tgaatttgtc caattgtgta   1980

gacgatatac tccctgccct tccccctgca aaaagaaaaa aagaaaagaa aaagaaaaaa   2040

atcccttgtt ctcagtggtg caggatgttg gcttggggca acagattgaa aagacctaca   2100

gactaagaag gaaaagaaga agagatgaca aaccataact gacaagagag gcgtctgctg   2160

tctcatcaca taaaaggctt cacttttgac tgagggcagc tttgcaaaat gagactttct   2220

aaatcaaacc aggtgcaatt atttctttat tttcttctcc agtggtcatt gggcagtgtt   2280

aatgctgaaa catcattaca gattctgcta gcctgttctt ttaccactga cagctagaca   2340

cctagaaagg aactgcaata atatcaaaac aagtactggt tgactttcta attagagagc   2400

atctgcaaca aaaagtcatt tttctggagt ggaaaagctt aaaaaaatta ctgtgaattg   2460

tttttgtaca gttatcatga aaagcttttt tttttttttt tttgccaacc attgccaatg   2520

tcaatcaatc acagtattag cctctgttaa tctatttact gttgcttcca tatacattct   2580

tcaatgcata tgttgctcaa aggtggcaag ttgtcctggg ttctgtgagt cctgagatgg   2640

atttaattct tgatgctggt gctagaagta ggtcttcaaa tatgggattg ttgtcccaac   2700

cctgtactgt actcccagtg gccaaactta tttatgctgc taaatgaaag aaagaaaaaa   2760

gcaaattatt tttttttatt ttttttctgc tgtgacgttt tagtcccaga ctgaattcca   2820

aatttgctct agtttggtta tggaaaaaag actttttgcc actgaaactt gagccatctg   2880

tgcctctaag aggctgagaa tggaagagtt tcagataata aagagtgaag tttgcctgca   2940

agtaaagaat tgagagtgtg tgcaaagctt attttctttt atctgggcaa aaattaaaac   3000

acattccttg gaacagagct attacttgcc tgttctgtgg agaaactttt ctttttgagg   3060

gctgtggtga atggatgaac gtacatcgta aaactgacaa aatattttaa aaatatataa   3120

aacacaaaat taaaataaag ttgctggtca gtcttagtgt tttacagtat ttgggaaaac   3180

aactgttaca gttttattgc tctgagtaac tgacaaagca gaaactattc agtttttgta   3240

gtaaaggcgt cacatgcaaa caaacaaaat gaatgaaaca gtcaaatggt ttgcctcatt   3300

ctccaagagc cacaactcaa gctgaactgt gaaagtggtt taacactgta tcctaggcga   3360

tcttttttcc tccttctgtt tatttttttg tttgttttat ttatagtctg atttaaaaca   3420

atcagattca agttggttaa ttttagttat gtaacaacct gacatgatgg aggaaaacaa   3480

cctttaaagg gattgtgtct atggtttgat tcacttagaa attttatttt cttataactt   3540

aagtgcaata aaatgtgttt tttcatgtta                                    3570


<210>  940
<211>  589
<212>  PRT
<213>  Homosapiens

<400>  940

Met Ser Lys Pro Gly Lys Pro Thr Leu Asn His Gly Leu Val Pro Val 
1               5                   10                  15      


Asp Leu Lys Ser Ala Lys Glu Pro Leu Pro His Gln Thr Val Met Lys 
            20                  25                  30          


Ile Phe Ser Ile Ser Ile Ile Ala Gln Gly Leu Pro Phe Cys Arg Arg 
        35                  40                  45              


Arg Met Lys Arg Lys Leu Asp His Gly Ser Glu Val Arg Ser Phe Ser 
    50                  55                  60                  


Leu Gly Lys Lys Pro Cys Lys Val Ser Glu Tyr Thr Ser Thr Thr Gly 
65                  70                  75                  80  


Leu Val Pro Cys Ser Ala Thr Pro Thr Thr Phe Gly Asp Leu Arg Ala 
                85                  90                  95      


Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg Ile Thr Ser Val Gln Pro 
            100                 105                 110         


Pro Thr Gly Leu Gln Glu Trp Leu Lys Met Phe Gln Ser Trp Ser Gly 
        115                 120                 125             


Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu Ile Asp Ser Cys Glu Pro 
    130                 135                 140                 


Thr Gln Val Lys His Met Met Gln Val Ile Glu Pro Gln Phe Gln Arg 
145                 150                 155                 160 


Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu Ala Leu Tyr Val Leu Ser 
                165                 170                 175     


Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala Ala Gln Thr Cys Arg Tyr 
            180                 185                 190         


Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu Trp Arg Glu Lys Cys Lys 
        195                 200                 205             


Glu Glu Gly Ile Asp Glu Pro Leu His Ile Lys Arg Arg Lys Val Ile 
    210                 215                 220                 


Lys Pro Gly Phe Ile His Ser Pro Trp Lys Ser Ala Tyr Ile Arg Gln 
225                 230                 235                 240 


His Arg Ile Asp Thr Asn Trp Arg Arg Gly Glu Leu Lys Ser Pro Lys 
                245                 250                 255     


Val Leu Lys Gly His Asp Asp His Val Ile Thr Cys Leu Gln Phe Cys 
            260                 265                 270         


Gly Asn Arg Ile Val Ser Gly Ser Asp Asp Asn Thr Leu Lys Val Trp 
        275                 280                 285             


Ser Ala Val Thr Gly Lys Cys Leu Arg Thr Leu Val Gly His Thr Gly 
    290                 295                 300                 


Gly Val Trp Ser Ser Gln Met Arg Asp Asn Ile Ile Ile Ser Gly Ser 
305                 310                 315                 320 


Thr Asp Arg Thr Leu Lys Val Trp Asn Ala Glu Thr Gly Glu Cys Ile 
                325                 330                 335     


His Thr Leu Tyr Gly His Thr Ser Thr Val Arg Cys Met His Leu His 
            340                 345                 350         


Glu Lys Arg Val Val Ser Gly Ser Arg Asp Ala Thr Leu Arg Val Trp 
        355                 360                 365             


Asp Ile Glu Thr Gly Gln Cys Leu His Val Leu Met Gly His Val Ala 
    370                 375                 380                 


Ala Val Arg Cys Val Gln Tyr Asp Gly Arg Arg Val Val Ser Gly Ala 
385                 390                 395                 400 


Tyr Asp Phe Met Val Lys Val Trp Asp Pro Glu Thr Glu Thr Cys Leu 
                405                 410                 415     


His Thr Leu Gln Gly His Thr Asn Arg Val Tyr Ser Leu Gln Phe Asp 
            420                 425                 430         


Gly Ile His Val Val Ser Gly Ser Leu Asp Thr Ser Ile Arg Val Trp 
        435                 440                 445             


Asp Val Glu Thr Gly Asn Cys Ile His Thr Leu Thr Gly His Gln Ser 
    450                 455                 460                 


Leu Thr Ser Gly Met Glu Leu Lys Asp Asn Ile Leu Val Ser Gly Asn 
465                 470                 475                 480 


Ala Asp Ser Thr Val Lys Ile Trp Asp Ile Lys Thr Gly Gln Cys Leu 
                485                 490                 495     


Gln Thr Leu Gln Gly Pro Asn Lys His Gln Ser Ala Val Thr Cys Leu 
            500                 505                 510         


Gln Phe Asn Lys Asn Phe Val Ile Thr Ser Ser Asp Asp Gly Thr Val 
        515                 520                 525             


Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe Ile Arg Asn Leu Val Thr 
    530                 535                 540                 


Leu Glu Ser Gly Gly Ser Gly Gly Val Val Trp Arg Ile Arg Ala Ser 
545                 550                 555                 560 


Asn Thr Lys Leu Val Cys Ala Val Gly Ser Arg Asn Gly Thr Glu Glu 
                565                 570                 575     


Thr Lys Leu Leu Val Leu Asp Phe Asp Val Asp Met Lys 
            580                 585                 


<210>  941
<211>  3603
<212>  DNA
<213>  Homosapiens

<400>  941
agtcaaggct ttgacagggc atagtctcct ccaataatct tctccgttct ctctcattat     60

tccctcgagt tcttctcagt caagctgcat gtatgtatgt gtgtcccgag aagcggtttg    120

atactgagct gcatttgcct ttactgtgga gttttgttgc cggttctgct ccctaatctt    180

ccttttctga cgtgcctgag catgtccaca ttagaatctg tgacatacct acctgaaaaa    240

ggtttatatt gtcagagact gccaagcagc cggacacacg ggggcacaga atcactgaag    300

gggaaaaata cagaaaatat gggtttctac ggcacattaa aaatgatttt ttacaaaatg    360

aaaagaaagt tggaccatgg ttctgaggtc cgctcttttt ctttgggaaa gaaaccatgc    420

aaagtctcag aatatacaag taccactggg cttgtaccat gttcagcaac accaacaact    480

tttggggacc tcagagcagc caatggccaa gggcaacaac gacgccgaat tacatctgtc    540

cagccaccta caggcctcca ggaatggcta aaaatgtttc agagctggag tggaccagag    600

aaattgcttg ctttagatga actcattgat agttgtgaac caacacaagt aaaacatatg    660

atgcaagtga tagaacccca gtttcaacga gacttcattt cattgctccc taaagagttg    720

gcactctatg tgctttcatt cctggaaccc aaagacctgc tacaagcagc tcagacatgt    780

cgctactgga gaattttggc tgaagacaac cttctctgga gagagaaatg caaagaagag    840

gggattgatg aaccattgca catcaagaga agaaaagtaa taaaaccagg tttcatacac    900

agtccatgga aaagtgcata catcagacag cacagaattg atactaactg gaggcgagga    960

gaactcaaat ctcctaaggt gctgaaagga catgatgatc atgtgatcac atgcttacag   1020

ttttgtggta accgaatagt tagtggttct gatgacaaca ctttaaaagt ttggtcagca   1080

gtcacaggca aatgtctgag aacattagtg ggacatacag gtggagtatg gtcatcacaa   1140

atgagagaca acatcatcat tagtggatct acagatcgga cactcaaagt gtggaatgca   1200

gagactggag aatgtataca caccttatat gggcatactt ccactgtgcg ttgtatgcat   1260

cttcatgaaa aaagagttgt tagcggttct cgagatgcca ctcttagggt ttgggatatt   1320

gagacaggcc agtgtttaca tgttttgatg ggtcatgttg cagcagtccg ctgtgttcaa   1380

tatgatggca ggagggttgt tagtggagca tatgatttta tggtaaaggt gtgggatcca   1440

gagactgaaa cctgtctaca cacgttgcag gggcatacta atagagtcta ttcattacag   1500

tttgatggta tccatgtggt gagtggatct cttgatacat caatccgtgt ttgggatgtg   1560

gagacaggga attgcattca cacgttaaca gggcaccagt cgttaacaag tggaatggaa   1620

ctcaaagaca atattcttgt ctctgggaat gcagattcta cagttaaaat ctgggatatc   1680

aaaacaggac agtgtttaca aacattgcaa ggtcccaaca agcatcagag tgctgtgacc   1740

tgtttacagt tcaacaagaa ctttgtaatt accagctcag atgatggaac tgtaaaacta   1800

tgggacttga aaacgggtga atttattcga aacctagtca cattggagag tggggggagt   1860

gggggagttg tgtggcggat cagagcctca aacacaaagc tggtgtgtgc agttgggagt   1920

cggaatggga ctgaagaaac caagctgctg gtgctggact ttgatgtgga catgaagtga   1980

agagcagaaa agatgaattt gtccaattgt gtagacgata tactccctgc ccttccccct   2040

gcaaaaagaa aaaaagaaaa gaaaaagaaa aaaatccctt gttctcagtg gtgcaggatg   2100

ttggcttggg gcaacagatt gaaaagacct acagactaag aaggaaaaga agaagagatg   2160

acaaaccata actgacaaga gaggcgtctg ctgtctcatc acataaaagg cttcactttt   2220

gactgagggc agctttgcaa aatgagactt tctaaatcaa accaggtgca attatttctt   2280

tattttcttc tccagtggtc attgggcagt gttaatgctg aaacatcatt acagattctg   2340

ctagcctgtt cttttaccac tgacagctag acacctagaa aggaactgca ataatatcaa   2400

aacaagtact ggttgacttt ctaattagag agcatctgca acaaaaagtc atttttctgg   2460

agtggaaaag cttaaaaaaa ttactgtgaa ttgtttttgt acagttatca tgaaaagctt   2520

tttttttttt ttttttgcca accattgcca atgtcaatca atcacagtat tagcctctgt   2580

taatctattt actgttgctt ccatatacat tcttcaatgc atatgttgct caaaggtggc   2640

aagttgtcct gggttctgtg agtcctgaga tggatttaat tcttgatgct ggtgctagaa   2700

gtaggtcttc aaatatggga ttgttgtccc aaccctgtac tgtactccca gtggccaaac   2760

ttatttatgc tgctaaatga aagaaagaaa aaagcaaatt attttttttt attttttttc   2820

tgctgtgacg ttttagtccc agactgaatt ccaaatttgc tctagtttgg ttatggaaaa   2880

aagacttttt gccactgaaa cttgagccat ctgtgcctct aagaggctga gaatggaaga   2940

gtttcagata ataaagagtg aagtttgcct gcaagtaaag aattgagagt gtgtgcaaag   3000

cttattttct tttatctggg caaaaattaa aacacattcc ttggaacaga gctattactt   3060

gcctgttctg tggagaaact tttctttttg agggctgtgg tgaatggatg aacgtacatc   3120

gtaaaactga caaaatattt taaaaatata taaaacacaa aattaaaata aagttgctgg   3180

tcagtcttag tgttttacag tatttgggaa aacaactgtt acagttttat tgctctgagt   3240

aactgacaaa gcagaaacta ttcagttttt gtagtaaagg cgtcacatgc aaacaaacaa   3300

aatgaatgaa acagtcaaat ggtttgcctc attctccaag agccacaact caagctgaac   3360

tgtgaaagtg gtttaacact gtatcctagg cgatcttttt tcctccttct gtttattttt   3420

ttgtttgttt tatttatagt ctgatttaaa acaatcagat tcaagttggt taattttagt   3480

tatgtaacaa cctgacatga tggaggaaaa caacctttaa agggattgtg tctatggttt   3540

gattcactta gaaattttat tttcttataa cttaagtgca ataaaatgtg ttttttcatg   3600

tta                                                                 3603


<210>  942
<211>  627
<212>  PRT
<213>  Homosapiens

<400>  942

Met Cys Val Pro Arg Ser Gly Leu Ile Leu Ser Cys Ile Cys Leu Tyr 
1               5                   10                  15      


Cys Gly Val Leu Leu Pro Val Leu Leu Pro Asn Leu Pro Phe Leu Thr 
            20                  25                  30          


Cys Leu Ser Met Ser Thr Leu Glu Ser Val Thr Tyr Leu Pro Glu Lys 
        35                  40                  45              


Gly Leu Tyr Cys Gln Arg Leu Pro Ser Ser Arg Thr His Gly Gly Thr 
    50                  55                  60                  


Glu Ser Leu Lys Gly Lys Asn Thr Glu Asn Met Gly Phe Tyr Gly Thr 
65                  70                  75                  80  


Leu Lys Met Ile Phe Tyr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                85                  90                  95      


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            100                 105                 110         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        115                 120                 125             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    130                 135                 140                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
145                 150                 155                 160 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                165                 170                 175     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            180                 185                 190         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        195                 200                 205             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    210                 215                 220                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
225                 230                 235                 240 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                245                 250                 255     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            260                 265                 270         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        275                 280                 285             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    290                 295                 300                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
305                 310                 315                 320 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                325                 330                 335     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            340                 345                 350         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        355                 360                 365             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    370                 375                 380                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
385                 390                 395                 400 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                405                 410                 415     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            420                 425                 430         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        435                 440                 445             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    450                 455                 460                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
465                 470                 475                 480 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                485                 490                 495     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            500                 505                 510         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        515                 520                 525             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    530                 535                 540                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
545                 550                 555                 560 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                565                 570                 575     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            580                 585                 590         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        595                 600                 605             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    610                 615                 620                 


Asp Met Lys 
625         


<210>  943
<211>  3896
<212>  DNA
<213>  Homosapiens

<400>  943
ccttccgcag ctgccgcttc agtccgaagg aggaagggaa ccaacccact ttctcggcgc     60

cgcggctctt ttctaaaagt aatgtgaaaa cctttgcatc ttctgatagt ctagccaagg    120

tccaagaagt agcaagctgg cttttggaaa tgaatcagga actgctctct gtgggcagca    180

aaagacgacg aactggaggc tctctgagag gtaacccttc ctcaagccag gtagatgaag    240

aacagatgaa tcgtgtggta gaggaggaac agcaacagca actcagacaa caagaggagg    300

agcacactgc aaggaatggt gaagttgttg gagtagaacc tagacctgga ggccaaaatg    360

attcccagca aggacagttg gaagaaaaca ataatagatt tatttcggta gatgaggact    420

cctcaggaaa ccaagaagaa caagaggaag atgaagaaca tgctggtgaa caagatgagg    480

aggatgagga ggaggaggag atggaccagg agagtgacga ttttgatcag tctgatgata    540

gtagcagaga agatgaacat acacatacta acagtgtcac gaactccagt agtattgtgg    600

acctgcccgt tcaccaactc tcctccccat tctatacaaa aacaacaaaa atgaaaagaa    660

agttggacca tggttctgag gtccgctctt tttctttggg aaagaaacca tgcaaagtct    720

cagaatatac aagtaccact gggcttgtac catgttcagc aacaccaaca acttttgggg    780

acctcagagc agccaatggc caagggcaac aacgacgccg aattacatct gtccagccac    840

ctacaggcct ccaggaatgg ctaaaaatgt ttcagagctg gagtggacca gagaaattgc    900

ttgctttaga tgaactcatt gatagttgtg aaccaacaca agtaaaacat atgatgcaag    960

tgatagaacc ccagtttcaa cgagacttca tttcattgct ccctaaagag ttggcactct   1020

atgtgctttc attcctggaa cccaaagacc tgctacaagc agctcagaca tgtcgctact   1080

ggagaatttt ggctgaagac aaccttctct ggagagagaa atgcaaagaa gaggggattg   1140

atgaaccatt gcacatcaag agaagaaaag taataaaacc aggtttcata cacagtccat   1200

ggaaaagtgc atacatcaga cagcacagaa ttgatactaa ctggaggcga ggagaactca   1260

aatctcctaa ggtgctgaaa ggacatgatg atcatgtgat cacatgctta cagttttgtg   1320

gtaaccgaat agttagtggt tctgatgaca acactttaaa agtttggtca gcagtcacag   1380

gcaaatgtct gagaacatta gtgggacata caggtggagt atggtcatca caaatgagag   1440

acaacatcat cattagtgga tctacagatc ggacactcaa agtgtggaat gcagagactg   1500

gagaatgtat acacacctta tatgggcata cttccactgt gcgttgtatg catcttcatg   1560

aaaaaagagt tgttagcggt tctcgagatg ccactcttag ggtttgggat attgagacag   1620

gccagtgttt acatgttttg atgggtcatg ttgcagcagt ccgctgtgtt caatatgatg   1680

gcaggagggt tgttagtgga gcatatgatt ttatggtaaa ggtgtgggat ccagagactg   1740

aaacctgtct acacacgttg caggggcata ctaatagagt ctattcatta cagtttgatg   1800

gtatccatgt ggtgagtgga tctcttgata catcaatccg tgtttgggat gtggagacag   1860

ggaattgcat tcacacgtta acagggcacc agtcgttaac aagtggaatg gaactcaaag   1920

acaatattct tgtctctggg aatgcagatt ctacagttaa aatctgggat atcaaaacag   1980

gacagtgttt acaaacattg caaggtccca acaagcatca gagtgctgtg acctgtttac   2040

agttcaacaa gaactttgta attaccagct cagatgatgg aactgtaaaa ctatgggact   2100

tgaaaacggg tgaatttatt cgaaacctag tcacattgga gagtgggggg agtgggggag   2160

ttgtgtggcg gatcagagcc tcaaacacaa agctggtgtg tgcagttggg agtcggaatg   2220

ggactgaaga aaccaagctg ctggtgctgg actttgatgt ggacatgaag tgaagagcag   2280

aaaagatgaa tttgtccaat tgtgtagacg atatactccc tgcccttccc cctgcaaaaa   2340

gaaaaaaaga aaagaaaaag aaaaaaatcc cttgttctca gtggtgcagg atgttggctt   2400

ggggcaacag attgaaaaga cctacagact aagaaggaaa agaagaagag atgacaaacc   2460

ataactgaca agagaggcgt ctgctgtctc atcacataaa aggcttcact tttgactgag   2520

ggcagctttg caaaatgaga ctttctaaat caaaccaggt gcaattattt ctttattttc   2580

ttctccagtg gtcattgggc agtgttaatg ctgaaacatc attacagatt ctgctagcct   2640

gttcttttac cactgacagc tagacaccta gaaaggaact gcaataatat caaaacaagt   2700

actggttgac tttctaatta gagagcatct gcaacaaaaa gtcatttttc tggagtggaa   2760

aagcttaaaa aaattactgt gaattgtttt tgtacagtta tcatgaaaag cttttttttt   2820

tttttttttg ccaaccattg ccaatgtcaa tcaatcacag tattagcctc tgttaatcta   2880

tttactgttg cttccatata cattcttcaa tgcatatgtt gctcaaaggt ggcaagttgt   2940

cctgggttct gtgagtcctg agatggattt aattcttgat gctggtgcta gaagtaggtc   3000

ttcaaatatg ggattgttgt cccaaccctg tactgtactc ccagtggcca aacttattta   3060

tgctgctaaa tgaaagaaag aaaaaagcaa attatttttt tttatttttt ttctgctgtg   3120

acgttttagt cccagactga attccaaatt tgctctagtt tggttatgga aaaaagactt   3180

tttgccactg aaacttgagc catctgtgcc tctaagaggc tgagaatgga agagtttcag   3240

ataataaaga gtgaagtttg cctgcaagta aagaattgag agtgtgtgca aagcttattt   3300

tcttttatct gggcaaaaat taaaacacat tccttggaac agagctatta cttgcctgtt   3360

ctgtggagaa acttttcttt ttgagggctg tggtgaatgg atgaacgtac atcgtaaaac   3420

tgacaaaata ttttaaaaat atataaaaca caaaattaaa ataaagttgc tggtcagtct   3480

tagtgtttta cagtatttgg gaaaacaact gttacagttt tattgctctg agtaactgac   3540

aaagcagaaa ctattcagtt tttgtagtaa aggcgtcaca tgcaaacaaa caaaatgaat   3600

gaaacagtca aatggtttgc ctcattctcc aagagccaca actcaagctg aactgtgaaa   3660

gtggtttaac actgtatcct aggcgatctt ttttcctcct tctgtttatt tttttgtttg   3720

ttttatttat agtctgattt aaaacaatca gattcaagtt ggttaatttt agttatgtaa   3780

caacctgaca tgatggagga aaacaacctt taaagggatt gtgtctatgg tttgattcac   3840

ttagaaattt tattttctta taacttaagt gcaataaaat gtgttttttc atgtta       3896


<210>  944
<211>  707
<212>  PRT
<213>  Homosapiens

<400>  944

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Thr Lys Thr Thr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                165                 170                 175     


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            180                 185                 190         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        195                 200                 205             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    210                 215                 220                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
225                 230                 235                 240 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                245                 250                 255     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            260                 265                 270         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        275                 280                 285             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
305                 310                 315                 320 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                325                 330                 335     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            340                 345                 350         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        355                 360                 365             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    370                 375                 380                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
385                 390                 395                 400 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                405                 410                 415     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            420                 425                 430         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        435                 440                 445             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    450                 455                 460                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
465                 470                 475                 480 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                485                 490                 495     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            500                 505                 510         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        515                 520                 525             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    530                 535                 540                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
545                 550                 555                 560 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                565                 570                 575     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            580                 585                 590         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        595                 600                 605             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    610                 615                 620                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
625                 630                 635                 640 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                645                 650                 655     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            660                 665                 670         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        675                 680                 685             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    690                 695                 700                 


Asp Met Lys 
705         


<210>  945
<211>  3007
<212>  DNA
<213>  Homosapiens

<400>  945
gcccggagag ccgcatctat tggcagcttt gttattgatc agaaactgct cgccgccgac     60

ttggcttcca gtctggctgc gggcaaccct tgagttttcg cctctgtcct gtcccccgaa    120

ctgacaggtg ctcccagcaa cttgctgggg acttctcgcc gctcccccgc gtccccaccc    180

cctcattcct ccctcgcctt cacccccacc cccaccactt cgccacagct caggatttgt    240

ttaaaccttg ggaaactggt tcaggtccag gttttgcttt gatccttttc aaaaactgga    300

gacacagaag agggctctag gaaaaagttt tggatgggat tatgtggaaa ctaccctgcg    360

attctctgct gccagagcag gctcggcgct tccaccccag tgcagccttc ccctggcggt    420

ggtgaaagag actcgggagt cgctgcttcc aaagtgcccg ccgtgagtga gctctcaccc    480

cagtcagcca aatgagcctc ttcgggcttc tcctgctgac atctgccctg gccggccaga    540

gacaggggac tcaggcggaa tccaacctga gtagtaaatt ccagttttcc agcaacaagg    600

aacagaacgg agtacaagat cctcagcatg agagaattat tactgtgtct actaatggaa    660

gtattcacag cccaaggttt cctcatactt atccaagaaa tacggtcttg gtatggagat    720

tagtagcagt agaggaaaat gtatggatac aacttacgtt tgatgaaaga tttgggcttg    780

aagacccaga agatgacata tgcaagtatg attttgtaga agttgaggaa cccagtgatg    840

gaactatatt agggcgctgg tgtggttctg gtactgtacc aggaaaacag atttctaaag    900

gaaatcaaat taggataaga tttgtatctg atgaatattt tccttctgaa ccagggttct    960

gcatccacta caacattgtc atgccacaat tcacagaagc tgtgagtcct tcagtgctac   1020

ccccttcagc tttgccactg gacctgctta ataatgctat aactgccttt agtaccttgg   1080

aagaccttat tcgatatctt gaaccagaga gatggcagtt ggacttagaa gatctatata   1140

ggccaacttg gcaacttctt ggcaaggctt ttgtttttgg aagaaaatcc agagtggtgg   1200

atctgaacct tctaacagag gaggtaagat tatacagctg cacacctcgt aacttctcag   1260

tgtccataag ggaagaacta aagagaaccg ataccatttt ctggccaggt tgtctcctgg   1320

ttaaacgctg tggtgggaac tgtgcctgtt gtctccacaa ttgcaatgaa tgtcaatgtg   1380

tcccaagcaa agttactaaa aaataccacg aggtccttca gttgagacca aagaccggtg   1440

tcaggggatt gcacaaatca ctcaccgacg tggccctgga gcaccatgag gagtgtgact   1500

gtgtgtgcag agggagcaca ggaggatagc cgcatcacca ccagcagctc ttgcccagag   1560

ctgtgcagtg cagtggctga ttctattaga gaacgtatgc gttatctcca tccttaatct   1620

cagttgtttg cttcaaggac ctttcatctt caggatttac agtgcattct gaaagaggag   1680

acatcaaaca gaattaggag ttgtgcaaca gctcttttga gaggaggcct aaaggacagg   1740

agaaaaggtc ttcaatcgtg gaaagaaaat taaatgttgt attaaataga tcaccagcta   1800

gtttcagagt taccatgtac gtattccact agctgggttc tgtatttcag ttctttcgat   1860

acggcttagg gtaatgtcag tacaggaaaa aaactgtgca agtgagcacc tgattccgtt   1920

gccttgctta actctaaagc tccatgtcct gggcctaaaa tcgtataaaa tctggatttt   1980

tttttttttt tttgctcata ttcacatatg taaaccagaa cattctatgt actacaaacc   2040

tggtttttaa aaaggaacta tgttgctatg aattaaactt gtgtcgtgct gataggacag   2100

actggatttt tcatatttct tattaaaatt tctgccattt agaagaagag aactacattc   2160

atggtttgga agagataaac ctgaaaagaa gagtggcctt atcttcactt tatcgataag   2220

tcagtttatt tgtttcattg tgtacatttt tatattctcc ttttgacatt ataactgttg   2280

gcttttctaa tcttgttaaa tatatctatt tttaccaaag gtatttaata ttctttttta   2340

tgacaactta gatcaactat ttttagcttg gtaaattttt ctaaacacaa ttgttatagc   2400

cagaggaaca aagatgatat aaaatattgt tgctctgaca aaaatacatg tatttcattc   2460

tcgtatggtg ctagagttag attaatctgc attttaaaaa actgaattgg aatagaattg   2520

gtaagttgca aagacttttt gaaaataatt aaattatcat atcttccatt cctgttattg   2580

gagatgaaaa taaaaagcaa cttatgaaag tagacattca gatccagcca ttactaacct   2640

attccttttt tggggaaatc tgagcctagc tcagaaaaac ataaagcacc ttgaaaaaga   2700

cttggcagct tcctgataaa gcgtgctgtg ctgtgcagta ggaacacatc ctatttattg   2760

tgatgttgtg gttttattat cttaaactct gttccataca cttgtataaa tacatggata   2820

tttttatgta cagaagtatg tctcttaacc agttcactta ttgtactctg gcaatttaaa   2880

agaaaatcag taaaatattt tgcttgtaaa atgcttaata tcgtgcctag gttatgtggt   2940

gactatttga atcaaaaatg tattgaatca tcaaataaaa gaatgtggct attttgggga   3000

gaaaatt                                                             3007


<210>  946
<211>  345
<212>  PRT
<213>  Homosapiens

<400>  946

Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly Gln 
1               5                   10                  15      


Arg Gln Gly Thr Gln Ala Glu Ser Asn Leu Ser Ser Lys Phe Gln Phe 
            20                  25                  30          


Ser Ser Asn Lys Glu Gln Asn Gly Val Gln Asp Pro Gln His Glu Arg 
        35                  40                  45              


Ile Ile Thr Val Ser Thr Asn Gly Ser Ile His Ser Pro Arg Phe Pro 
    50                  55                  60                  


His Thr Tyr Pro Arg Asn Thr Val Leu Val Trp Arg Leu Val Ala Val 
65                  70                  75                  80  


Glu Glu Asn Val Trp Ile Gln Leu Thr Phe Asp Glu Arg Phe Gly Leu 
                85                  90                  95      


Glu Asp Pro Glu Asp Asp Ile Cys Lys Tyr Asp Phe Val Glu Val Glu 
            100                 105                 110         


Glu Pro Ser Asp Gly Thr Ile Leu Gly Arg Trp Cys Gly Ser Gly Thr 
        115                 120                 125             


Val Pro Gly Lys Gln Ile Ser Lys Gly Asn Gln Ile Arg Ile Arg Phe 
    130                 135                 140                 


Val Ser Asp Glu Tyr Phe Pro Ser Glu Pro Gly Phe Cys Ile His Tyr 
145                 150                 155                 160 


Asn Ile Val Met Pro Gln Phe Thr Glu Ala Val Ser Pro Ser Val Leu 
                165                 170                 175     


Pro Pro Ser Ala Leu Pro Leu Asp Leu Leu Asn Asn Ala Ile Thr Ala 
            180                 185                 190         


Phe Ser Thr Leu Glu Asp Leu Ile Arg Tyr Leu Glu Pro Glu Arg Trp 
        195                 200                 205             


Gln Leu Asp Leu Glu Asp Leu Tyr Arg Pro Thr Trp Gln Leu Leu Gly 
    210                 215                 220                 


Lys Ala Phe Val Phe Gly Arg Lys Ser Arg Val Val Asp Leu Asn Leu 
225                 230                 235                 240 


Leu Thr Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro Arg Asn Phe Ser 
                245                 250                 255     


Val Ser Ile Arg Glu Glu Leu Lys Arg Thr Asp Thr Ile Phe Trp Pro 
            260                 265                 270         


Gly Cys Leu Leu Val Lys Arg Cys Gly Gly Asn Cys Ala Cys Cys Leu 
        275                 280                 285             


His Asn Cys Asn Glu Cys Gln Cys Val Pro Ser Lys Val Thr Lys Lys 
    290                 295                 300                 


Tyr His Glu Val Leu Gln Leu Arg Pro Lys Thr Gly Val Arg Gly Leu 
305                 310                 315                 320 


His Lys Ser Leu Thr Asp Val Ala Leu Glu His His Glu Glu Cys Asp 
                325                 330                 335     


Cys Val Cys Arg Gly Ser Thr Gly Gly 
            340                 345 


<210>  947
<211>  2649
<212>  DNA
<213>  Homosapiens

<400>  947
ctgggacgca gctgcccccg ctcggcgccc gctgcaccct tagcagccac tgccacctgg     60

gcccggagcc tccacgatct cgcccggcga ttgtgggcag gggcgcctcc ggatcgatct    120

tctgaaattc aagttttcaa gatgaagttt ttattgacaa ctgccttttt aattttaatt    180

tccttgtggg tggaagaagc ctattctaag gaaaagtctt caaagaaagg gaaggggaaa    240

aagaagcagt atctatgccc atctcagcag tcagcagagg accttgcccg agtacctgcc    300

aactccacta gcaatatctt gaacaggtta ttggtcagtt atgatcccag gataagacca    360

aacttcaaag gcattcctgt tgatgtagta gtcaacattt ttattaacag ttttggatcc    420

attcaagaaa caacaatgga ctatagagtt aacatcttcc tgagacaaaa atggaatgac    480

cccaggctga agctccccag tgattttagg ggttcagatg cactgacagt ggatccaaca    540

atgtacaagt gtttatggaa acctgattta ttttttgcaa atgaaaaaag tgccaatttt    600

catgatgtga cccaggaaaa catcctcctc tttatttttc gtgatggaga tgtccttgtc    660

agcatgaggt tatctattac tctttcatgc cctttggact tgacattgtt tcccatggat    720

acacaacgtt gcaagatgca actggagagc tttggttaca caactgatga tttacgattt    780

atctggcagt caggagatcc tgtgcaatta gaaaaaattg ccttgcctca atttgatatc    840

aaaaaggaag atattgaata tggtaactgt acaaaatact ataaaggcac gggctactac    900

acatgcgtgg aagtcatctt caccctgagg aggcaggtcg gcttttacat gatgggggtc    960

tacgccccaa ccctgctcat tgttgttctc tcctggcttt ccttctggat caacccggac   1020

gcgagtgctg ccagagtgcc cctgggtatc ttctcagtcc tcagcttggc ctctgagtgc   1080

acaacccttg ccgctgagct tcccaaagtt tcctatgtga aggctcttga tgtttggctt   1140

attgcttgcc ttctctttgg gtttgcttcc ctggtggagt atgcagttgt ccaggtgatg   1200

ctgaacaacc ccaaaagggt tgaagctgaa aaagccagaa ttgctaaggc tgagcaagca   1260

gatggaaaag gtggaaatgt ggctaaaaag aatactgtga atggaacagg gactcctgtt   1320

catattagca ctttgcaggt tggtgagacc agatgcaaaa aagtttgtac ttctaagtct   1380

gatctgagat ctaatgactt cagcattgtt ggaagcttac caagagattt tgaactatcc   1440

aattatgact gctatggaaa acccattgaa gttaacaacg gacttgggaa atctcaggct   1500

aagaacaaca agaagcctcc ccctgcgaaa cctgttattc caacagcagc aaagcgaatt   1560

gatctttatg caagagcatt gtttcctttc tgcttcttgt tcttcaatgt tatatattgg   1620

tctatatatt tatgataaat cttttccatt tgtacaaaat aaaattccat ttcattgtga   1680

cctactcctt tcataaatgc caatctgtga gaacttttga attttcatag caacattgca   1740

ttttggatgc catttgattg taataaaact gtggcacctt aattttgaat ggcagcatga   1800

tcatgtaata tctgtgctct aataacgatg tatatatgta tagtgaacat attgcttagt   1860

aacaaatgaa ggacaagcat actacataat ataatccata caattctctt cagttagtgt   1920

aaactgcaaa tactacagat aattctgata ataaaatgat atgcacgctg aatcctgcta   1980

tggtcaccat tctaatgtat gtagtatttc aaatttcctt ccttgtaact ttcaaagaaa   2040

gccatcttat tcttgtaatt ttagatggta ttatcacaga tttaaaaagg ttgtattaca   2100

tattgtttaa actttgtaag tagaaatata tctgttataa ttatacaggc tctgtggaga   2160

aataaagttc aaaatatatt aatttgtaaa atcagctcgt tttaaagtgt gcttgtgttg   2220

tcaaaaatat cagatagtaa tacacagtga gcatttttaa acaaagggaa acctatattt   2280

atgtaactgt atactgaatt ctgacaaaat aaaaaaagat accttattga cgaaatattt   2340

aggataaaca aaattctatt taatccacct taaaacctaa atgtattttc atggatttca   2400

tttgttggta catattacac aaaacattgt gccttaaaat gagtcataca tcttttaaat   2460

tggaatgcag taatagatat gtgattttac atcattttta agaaaccaag gggaagtaat   2520

aagttgaaaa agaaatccat aactattaaa agattttaac ttttttattt tattaaaatg   2580

cttgcatatt ttaagtaaaa ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2640

aaaaaaaaa                                                           2649


<210>  948
<211>  497
<212>  PRT
<213>  Homosapiens

<400>  948

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Gln Gln Ser Ala Glu Asp Leu 
        35                  40                  45              


Ala Arg Val Pro Ala Asn Ser Thr Ser Asn Ile Leu Asn Arg Leu Leu 
    50                  55                  60                  


Val Ser Tyr Asp Pro Arg Ile Arg Pro Asn Phe Lys Gly Ile Pro Val 
65                  70                  75                  80  


Asp Val Val Val Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Gln Glu 
                85                  90                  95      


Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Lys Trp Asn 
            100                 105                 110         


Asp Pro Arg Leu Lys Leu Pro Ser Asp Phe Arg Gly Ser Asp Ala Leu 
        115                 120                 125             


Thr Val Asp Pro Thr Met Tyr Lys Cys Leu Trp Lys Pro Asp Leu Phe 
    130                 135                 140                 


Phe Ala Asn Glu Lys Ser Ala Asn Phe His Asp Val Thr Gln Glu Asn 
145                 150                 155                 160 


Ile Leu Leu Phe Ile Phe Arg Asp Gly Asp Val Leu Val Ser Met Arg 
                165                 170                 175     


Leu Ser Ile Thr Leu Ser Cys Pro Leu Asp Leu Thr Leu Phe Pro Met 
            180                 185                 190         


Asp Thr Gln Arg Cys Lys Met Gln Leu Glu Ser Phe Gly Tyr Thr Thr 
        195                 200                 205             


Asp Asp Leu Arg Phe Ile Trp Gln Ser Gly Asp Pro Val Gln Leu Glu 
    210                 215                 220                 


Lys Ile Ala Leu Pro Gln Phe Asp Ile Lys Lys Glu Asp Ile Glu Tyr 
225                 230                 235                 240 


Gly Asn Cys Thr Lys Tyr Tyr Lys Gly Thr Gly Tyr Tyr Thr Cys Val 
                245                 250                 255     


Glu Val Ile Phe Thr Leu Arg Arg Gln Val Gly Phe Tyr Met Met Gly 
            260                 265                 270         


Val Tyr Ala Pro Thr Leu Leu Ile Val Val Leu Ser Trp Leu Ser Phe 
        275                 280                 285             


Trp Ile Asn Pro Asp Ala Ser Ala Ala Arg Val Pro Leu Gly Ile Phe 
    290                 295                 300                 


Ser Val Leu Ser Leu Ala Ser Glu Cys Thr Thr Leu Ala Ala Glu Leu 
305                 310                 315                 320 


Pro Lys Val Ser Tyr Val Lys Ala Leu Asp Val Trp Leu Ile Ala Cys 
                325                 330                 335     


Leu Leu Phe Gly Phe Ala Ser Leu Val Glu Tyr Ala Val Val Gln Val 
            340                 345                 350         


Met Leu Asn Asn Pro Lys Arg Val Glu Ala Glu Lys Ala Arg Ile Ala 
        355                 360                 365             


Lys Ala Glu Gln Ala Asp Gly Lys Gly Gly Asn Val Ala Lys Lys Asn 
    370                 375                 380                 


Thr Val Asn Gly Thr Gly Thr Pro Val His Ile Ser Thr Leu Gln Val 
385                 390                 395                 400 


Gly Glu Thr Arg Cys Lys Lys Val Cys Thr Ser Lys Ser Asp Leu Arg 
                405                 410                 415     


Ser Asn Asp Phe Ser Ile Val Gly Ser Leu Pro Arg Asp Phe Glu Leu 
            420                 425                 430         


Ser Asn Tyr Asp Cys Tyr Gly Lys Pro Ile Glu Val Asn Asn Gly Leu 
        435                 440                 445             


Gly Lys Ser Gln Ala Lys Asn Asn Lys Lys Pro Pro Pro Ala Lys Pro 
    450                 455                 460                 


Val Ile Pro Thr Ala Ala Lys Arg Ile Asp Leu Tyr Ala Arg Ala Leu 
465                 470                 475                 480 


Phe Pro Phe Cys Phe Leu Phe Phe Asn Val Ile Tyr Trp Ser Ile Tyr 
                485                 490                 495     


Leu 
    


<210>  949
<211>  5644
<212>  DNA
<213>  Homosapiens

<400>  949
aggagagagg gagaagagag cgcgagagag ggtgagtgtg tgtgagtgca tgggagggtg     60

ctgaatattc cgagacactg ggaccacagc ggcagctccg ctgaaaactg cattcagcca    120

gtcctccgga cttctggagc ggggacaggg cgcagggcat cagcagccac cagcaggacc    180

tgggaaatag ggattcttct gcctccactt caggttttag cagcttggtg ctaaattgct    240

gtctcaaaat gcagaggatc taatttgcag aggaaaacag ccaaagaagg aagaggagga    300

aaaggaaaaa aaaaggggta tattgtggat gctctacttt tcttggaaat gcaaaagatt    360

atgcatattt ctgtcctcct ttctcctgtt ttatggggac tgatttttgg tgtctcttct    420

aacagcatac agataggggg gctatttcct aggggcgccg atcaagaata cagtgcattt    480

cgagtaggga tggttcagtt ttccacttcg gagttcagac tgacacccca catcgacaat    540

ttggaggtgg caaacagctt cgcagtcact aatgctttct gctcccagtt ttcgagagga    600

gtctatgcta tttttggatt ttatgacaag aagtctgtaa ataccatcac atcattttgc    660

ggaacactcc acgtctcctt catcactccc agcttcccaa cagatggcac acatccattt    720

gtcattcaga tgagacccga cctcaaagga gctctcctta gcttgattga atactatcaa    780

tgggacaagt ttgcatacct ctatgacagt gacagaggct tatcaacact gcaagctgtg    840

ctggattctg ctgctgaaaa gaaatggcaa gtgactgcta tcaatgtggg aaacattaac    900

aatgacaaga aagatgagat gtaccgatca ctttttcaag atctggagtt aaaaaaggaa    960

cggcgtgtaa ttctggactg tgaaagggat aaagtaaacg acattgtaga ccaggttatt   1020

accattggaa aacatgttaa agggtaccac tacatcattg caaatctggg atttactgat   1080

ggagacctat taaaaatcca gtttggaggt gcaaatgtct ctggatttca gatagtggac   1140

tatgatgatt cgttggtatc taaatttata gaaagatggt caacactgga agaaaaagaa   1200

taccctggag ctcacacaac aacaattaag tatacttctg ctctgaccta tgatgccgtt   1260

caagtgatga ctgaagcctt ccgcaaccta aggaagcaaa gaattgaaat ctcccgaagg   1320

gggaatgcag gagactgtct ggcaaaccca gcagtgccct ggggacaagg tgtagaaata   1380

gaaagggccc tcaaacaggt tcaggttgaa ggtctctcag gaaatataaa gtttgaccag   1440

aatggaaaaa gaataaacta tacaattaac atcatggagc tcaaaactaa tgggccccgg   1500

aagattggct actggagtga agtggacaaa atggttgtta cccttactga gctcccttct   1560

ggaaatgaca cctctgggct tgagaataag actgttgttg tcaccacaat tttggaatct   1620

ccgtatgtta tgatgaagaa aaatcatgaa atgcttgaag gcaatgagcg ctatgagggc   1680

tactgtgttg acctggctgc agaaatcgcc aaacattgtg ggttcaagta caagttgaca   1740

attgttggtg atggcaagta tggggccagg gatgcagaca cgaaaatttg gaatgggatg   1800

gttggagaac ttgtatatgg gaaagctgat attgcaattg ctccattaac tattaccctt   1860

gtgagagaag aggtgattga cttctcaaag cccttcatga gcctcgggat atctatcatg   1920

atcaagaagc ctcagaagtc caaaccagga gtgttttcct ttcttgatcc tttagcctat   1980

gagatctgga tgtgcattgt ttttgcctac attggggtca gtgtagtttt attcctggtc   2040

agcagattta gcccctacga gtggcacact gaggagtttg aagatggaag agaaacacaa   2100

agtagtgaat caactaatga atttgggatt tttaatagtc tctggttttc cttgggtgcc   2160

tttatgcggc aaggatgcga tatttcgcca agatccctct ctgggcgcat tgttggaggt   2220

gtgtggtggt tctttaccct gatcataatc tcctcctaca cggctaactt agctgccttc   2280

ctgactgtag agaggatggt gtctcccatc gaaagtgctg aggatctttc taagcaaaca   2340

gaaattgctt atggaacatt agactctggc tccactaaag agtttttcag gagatctaaa   2400

attgcagtgt ttgataaaat gtggacctac atgcggagtg cggagccctc tgtgtttgtg   2460

aggactacgg ccgaaggggt ggctagagtg cggaagtcca aagggaaata tgcctacttg   2520

ttggagtcca cgatgaacga gtacattgag caaaggaagc cttgcgacac catgaaagtt   2580

ggtggaaacc tggattccaa aggctatggc atcgcaacac ctaaaggatc ctcattaaga   2640

accccagtaa atcttgcagt attgaaactc agtgagcaag gcgtcttaga caagctgaaa   2700

aacaaatggt ggtacgataa aggtgaatgt ggagccaagg actctggaag taaggaaaag   2760

accagtgccc tcagtctgag caacgttgct ggagtattct acatccttgt cgggggcctt   2820

ggtttggcaa tgctggtggc tttgattgag ttctgttaca agtcaagggc cgaggcgaaa   2880

cgaatgaagg tggcaaagaa tgcacagaat attaacccat cttcctcgca gaattcacag   2940

aattttgcaa cttataagga aggttacaac gtatatggca tcgaaagtgt taaaatttag   3000

gggatgacct tgaatgatgc catgaggaac aaggcaaggc tgtcaattac aggaagtact   3060

ggagaaaatg gacgtgttat gactccagaa tttcccaaag cagtgcatgc tgtcccttac   3120

gtgagtcctg gcatgggaat gaatgtcagt gtgactgatc tctcgtgatt gataagaacc   3180

ttttgagtgc cttacacaat ggttttcttg tgtgtttatt gtcaaagtgg tgagaggcat   3240

ccagtatctt gaagactttt ctttcagcca agaattctta aatatgtgga gttcatcttg   3300

aattgtaagg aatgattaat taaaacacaa catctttttc tactcgagtt acagacaaag   3360

cgtggtggac atgcacagct aacatggaag tactataatt tacctgaagt ctttgtacag   3420

acaacaaacc tgtttctgca gccactattg ttagtctctt gattcataat gacttaagca   3480

cacttgacat caactgcatc aagatgtgac atgttttata aaaaaaggaa aaaaaacatt   3540

taaaactaaa aaatattttt aggtattttc acaaacaaac tggcttttaa ataaatttgc   3600

ttccatattg gttgaataag acaaaaacaa ttaaactgag tgggaagtga ataaaaaaag   3660

gctttaggta tcgattccat atttttcaaa gccaaatatg taaatgctaa ggaaagtaaa   3720

caaagaggag attccaatct tgtaatttaa tattgttatt aaaactttaa tgtatcctat   3780

tctttaacat ttggtgttaa tataaaatta cttggcaatg cttgacattt gaaataaaca   3840

tttttctatt gttttattgc aagtggtcca attaattttg cttagctaca gtttggtcat   3900

aaatcaagtg agtttaaaga cactaccaag ttgttaggtg cccagagaaa atttctccct   3960

tttaaaaagg ccaggtgatt tttcaaatgt aatcttgccc ccaaagtaat atctgaatat   4020

ctttttgaca tgtctaaata tatatatata taaagaaata tttgttaaca caaaagcatt   4080

tgatctatgt agataaatgc taatagattt aaaaagctaa tattaacaaa taccagaata   4140

cgtgaagttc catttttaaa gtgtttgagc ttacagaaga gaaacattca ttttaaatga   4200

agtaaaaaat gccttgaaag taattcttta gatagttgcc cattgattaa attccaaaaa   4260

ctaaatatgt ttttagcttt aaaattataa aagctgtcat aaactttata tattatgaat   4320

tttaaaatat gtttgagtct cctgcaatat agtttcatcc cattgacatc aattaaaaat   4380

aaccctaata tattattttt atatttattc ctcaggtgga atggctattt taatatgccc   4440

agtgtggata aaatgtcaca tttctgtaac ttttgactaa agagcctata tttatctagt   4500

taatgaattt aaaggatcta tctttccctt cataaaatac ctcttatttc cattaaagcc   4560

ccccaagttt aattaattta ggattttgaa tgattattga catccaatag ttatttttaa   4620

tatttgtatt cttgttattt ctggaagaaa gcctttgtgt agcacttggt attttgcaaa   4680

gtgcttttaa aacattctta cttaccgtat ttcatagaag ggaaggaaaa atgtaaggtt   4740

taacagtaag cacttgcatt gaacatggag gcatgtggta tcatgatatt cttcactaaa   4800

tttagctgtc cctaatcaca gatcctaagg taatataata taattttagt gcatttctcc   4860

tcatcaggaa tgctggaggt gcattttaag ttttaataat aagtgctaga atgaccaaat   4920

tgcagactaa ttgtttccat attgtactta aaatgagttt ttaaaagtga aaaagaaatg   4980

actatataca atcaatgcta tttattgtac ctctgggcct actcttctaa aaattgtagc   5040

ttatcgattt ttctctgtca agcttgaact aatgtaaata attgaaataa tgtaaagtta   5100

tattttcatg tttttataga tacaacatga caagaataca taatgtaaga gtatttcaac   5160

tatggataat gttgattgga taatgcacat ctcagttaca agcagtactc atagtttaat   5220

atccatgtaa cggtgcatca atatattgct atataaatat gtctgtgtgc atataagtga   5280

aaagtggtca aacaagagtg atgacagctg tctaaaggtt tttttattca ttttatataa   5340

aaactgttat ggaaagacca aaatgtttat gaactattct tatgtaaatt tacaattgtc   5400

ctttactgta cttttttgtt tacagtatag taccttattt tctgctgtgt taagtgggtg   5460

tcaaactcca agaagacata cactttctat aacttctatt gaagatattg gaatttccaa   5520

tttttcatgt gtactatgtc agaaaatgct ttcgatttta tttttaaatc taacatcgga   5580

tggcttttcc ggagtgttgt aaaaacttca atcatacata aaacatgttc ttacaaaagg   5640

caaa                                                                5644


<210>  950
<211>  883
<212>  PRT
<213>  Homosapiens

<400>  950

Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp 
1               5                   10                  15      


Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met 
        35                  40                  45              


Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn 
    50                  55                  60                  


Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln 
65                  70                  75                  80  


Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser 
                85                  90                  95      


Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile 
            100                 105                 110         


Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met 
        115                 120                 125             


Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln 
    130                 135                 140                 


Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr 
145                 150                 155                 160 


Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr 
                165                 170                 175     


Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr 
            180                 185                 190         


Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile 
        195                 200                 205             


Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile 
    210                 215                 220                 


Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu 
225                 230                 235                 240 


Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn 
                245                 250                 255     


Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys 
            260                 265                 270         


Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala 
        275                 280                 285             


His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val 
    290                 295                 300                 


Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu 
305                 310                 315                 320 


Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val 
                325                 330                 335     


Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln 
            340                 345                 350         


Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg 
        355                 360                 365             


Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg 
    370                 375                 380                 


Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr 
385                 390                 395                 400 


Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val 
                405                 410                 415     


Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn 
            420                 425                 430         


His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp 
        435                 440                 445             


Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr 
    450                 455                 460                 


Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile 
465                 470                 475                 480 


Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala 
                485                 490                 495     


Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro 
        515                 520                 525             


Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr 
    530                 535                 540                 


Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val 
545                 550                 555                 560 


Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu 
                565                 570                 575     


Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe 
            580                 585                 590         


Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Arg Gln 
        595                 600                 605             


Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly 
    610                 615                 620                 


Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn 
625                 630                 635                 640 


Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser 
                645                 650                 655     


Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp 
            660                 665                 670         


Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe 
        675                 680                 685             


Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val 
    690                 695                 700                 


Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys 
705                 710                 715                 720 


Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg 
                725                 730                 735     


Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly 
            740                 745                 750         


Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val Asn 
        755                 760                 765             


Leu Ala Val Leu Lys Leu Ser Glu Gln Gly Val Leu Asp Lys Leu Lys 
    770                 775                 780                 


Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser Gly 
785                 790                 795                 800 


Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val 
                805                 810                 815     


Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu 
            820                 825                 830         


Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Val 
        835                 840                 845             


Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser Gln 
    850                 855                 860                 


Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu Ser 
865                 870                 875                 880 


Val Lys Ile 
            


<210>  951
<211>  3021
<212>  DNA
<213>  Homosapiens

<400>  951
aagagggagg ggtctgtgcg cccgcagagt cgccaggcgc cctgcgagtt gtctccgctg     60

ggaggggcga ggctgtcact tgccagggcg cgaggagcct cagcgcggct tggagaactt    120

ggccccgcgc agcgtctggt cactcgctct cctctgggga ctgcagagaa gcaggacctc    180

gggccatgga ttctactgaa gaaaggtagc catggaagag aatatggaag agggacagac    240

acaaaaaggg tgttttgaat gctgtatcaa atgcctgggg ggcattccct atgcctctct    300

gattgccacc atcctgctct atgcgggtgt tgccctgttc tgtggctgcg gtcatgaagc    360

gctttctgga actgtcaaca ttctgcaaac ctactttgag atggcaagaa ctgctggaga    420

cacactggat gtttttacca tgattgacat ctttaagtat gtgatctacg gcatcgcagc    480

tgcgttcttt gtgtatggca ttttgctgat ggtggaaggt ttcttcacaa ctggggccat    540

caaagatctc tatggggatt tcaaaatcac cacttgtggc agatgtgtga gcgcttggtt    600

cattatgctg acatatcttt tcatgttggc ctggctggga gtcacggctt tcacctcact    660

gccagtttac atgtacttca atctgtggac catctgccgg aacaccacat tagtggaggg    720

agcaaatctc tgcttggacc ttcgtcagtt tggaattgtg acaattggag aggaaaagaa    780

aatttgtact gtctctgaga atttcttgag gatgtgcgaa tctactgagc tgaacatgac    840

cttccacttg tttattgtgg cacttgctgg agctggggca gcagtcattg ctatggttca    900

ctaccttatg gttctgtctg ccaactgggc ctatgtgaaa gacgcctgcc ggatgcagaa    960

gtatgaagac atcaagtcga aggaagagca agagcttcat gacatccact ctactcgctc   1020

caaagagcgg ctcaatgcat acacataaat gcatcttcct gttctttcta ccatttgaat   1080

gcattggtgt ttaactaagg gccatccaac catccaacct ttaaaaaaca aaacgaaagt   1140

gcttctcatc aatgatatgt aaggtgactt atgaatcacc tgagtacaat tctttgttgt   1200

ttagcactta aatttcccaa tttattaaat tgatgtaaat cagatctttt ctacaagctc   1260

ctatccagcc ttttttttga aatttctcaa actcatttac tagttctgta aaatcaaaga   1320

tactaacatt gtcaaatgca aagatttgtt tgatttttaa ccacttccca tgtgttatac   1380

ataacacctt ttgcattatt tcttatgttt tgaaaagaaa atagcttttt atacttttta   1440

gttttgattt cggtaactag tttaactaca ggtaaccttc aaagggacca ttgtacatta   1500

tgaacaatag atagagatta catcttgatg actcttgaaa tatggaaatt ttgtctgaag   1560

atcagtggcc atattactgt aggccctggt tcatgttttc atcaatctaa ggtgcaattt   1620

ctaaatttgt aagagtaggt ttaaaaaaaa aagtgcttct tatctttgtt aacattgtac   1680

ttttccttga tgttcttaaa aggtatttcc ctcagattac tcatgtttat gttgtgagca   1740

tgtagaaaca gtaatgctaa tgcatggcta gttgcctttt taagattgtg acaccaggct   1800

taccttttaa agtttagtat atagagacaa ttttaatgga aataactact gtagactatt   1860

gaagaatgat ctctttgtga tttaagaagt ggctggattg gaacttttaa tatgctaatg   1920

tggaaaatta attaccttta tgaaggtggt ttattacaaa taagcacact aacccctcgg   1980

aagttgtttt acctacttta aaagttttaa tggattgcac ctctgtaaac tattcctaaa   2040

atgtgtatga tatatttgaa aaggcttcca ttaatataat agctttgctt gcagccttcc   2100

aatctatgtt ggtttacctg tagtgtttta taaagtgtgg tcagaggccc ctatagaatg   2160

tattgtttga aagtgtagtg atatatttgt gtttttattt caagtaagtc attttaaccg   2220

aatgttcatt catattcatt tataaaaagt acctgtatca aaggaatttt aacaaagagc   2280

aatcagtatt attggaccaa atttggtgtt tgttttcacc ttgacgctct tcttttcatt   2340

atttctaatg ctacaagaat gctgtaaagt gtcttctaaa atgatgtagc ctgacaagac   2400

atttttttca gtgtataaaa ctaggtagta ttgtgcactg atttgaccat tgtgaaatcc   2460

tttctcagtg taactgcatt tctaataaaa atttattgag tgaaacaatc tttgtacaat   2520

gactagtcat gcatcatcag taattttaca agttcttgta gtaggtaggg ggtactacta   2580

gggatatctg tggcatgatt atgcattccg tagtattatt taattaattt ggggttcatt   2640

ttgcttcctt ttctttatgc ttagattatc ttactggttc aacatttttc tgatatatgc   2700

agtattacag atattcagca aaagtattaa tgggcttctt taaattctat attatagtat   2760

ttcagttccg tgtcttaaca gtttgtgata atttctaaaa ctgtcttttc aacttatgta   2820

atgatgttga cacttttggc ttttatttct ggtattagag tttgtatttt cacagagtgc   2880

tttgtagcag gcattacaat taatctgttt tgtacataaa tgtgccaaca gcttgatggt   2940

ggcgtttttg aaatgtagaa cagagtgctt gcaaaatgta ataaatacac ttgtgtactt   3000

tgtgtactta ttattaaaaa a                                             3021


<210>  952
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  952

Met Glu Glu Asn Met Glu Glu Gly Gln Thr Gln Lys Gly Cys Phe Glu 
1               5                   10                  15      


Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr Ala Ser Leu Ile Ala 
            20                  25                  30          


Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe Cys Gly Cys Gly His 
        35                  40                  45              


Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln Thr Tyr Phe Glu Met 
    50                  55                  60                  


Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr Met Ile Asp Ile 
65                  70                  75                  80  


Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala Phe Phe Val Tyr Gly 
                85                  90                  95      


Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr Gly Ala Ile Lys Asp 
            100                 105                 110         


Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly Arg Cys Val Ser Ala 
        115                 120                 125             


Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu Ala Trp Leu Gly Val 
    130                 135                 140                 


Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr Phe Asn Leu Trp Thr 
145                 150                 155                 160 


Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala Asn Leu Cys Leu Asp 
                165                 170                 175     


Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu Glu Lys Lys Ile Cys 
            180                 185                 190         


Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu Ser Thr Glu Leu Asn 
        195                 200                 205             


Met Thr Phe His Leu Phe Ile Val Ala Leu Ala Gly Ala Gly Ala Ala 
    210                 215                 220                 


Val Ile Ala Met Val His Tyr Leu Met Val Leu Ser Ala Asn Trp Ala 
225                 230                 235                 240 


Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr Glu Asp Ile Lys Ser 
                245                 250                 255     


Lys Glu Glu Gln Glu Leu His Asp Ile His Ser Thr Arg Ser Lys Glu 
            260                 265                 270         


Arg Leu Asn Ala Tyr Thr 
        275             


<210>  953
<211>  3614
<212>  DNA
<213>  Homosapiens

<400>  953
atctctcagg cttagagctt tatactcact cctttgacag ccacgcttct atttcttttt     60

aaatctcaaa ggtgtgggat tacaagtcct gtcttagtaa taaacttttg cagataaacc    120

ctgagatggt ataactgcat cctttcttgg caccttaaat caaattaact aaatacttag    180

tgaggagaga aaaggaaaac acagtttttt tgcaacgtat ctgactgggt gagaagccac    240

tgctgcagca taaagaaccg acgggaatct gggctttccc actctggaat gaagggggga    300

attacgggtt ggtggtcggc ttcatgttag gaggacaccc ctccatctgt tcacagctca    360

gcctgtttcc aatttaaagc ccagatttca atacaaacct caatttcttt tccccatttt    420

aaatgcaaag caagacttgt gaatcatagt gtctctgctc ctgggattca gaccaaattt    480

ccccccaaaa ttctcaggct atttgtttga atacctgctt acagtggtac acaatgggca    540

gctttgagaa gaaaaattga taatcttcac ggaagagtaa tttgaatgaa attacacttg    600

acagcctgtc tccaagcaaa caagaggaac gagggagcct gagctaagct ctgaggactt    660

gcccaagcca ctgctgttgg agcttcccag gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    720

aaaaaaaaaa acaccagttt ttccaacatc taattgagct tttgattaat tccgtgtacc    780

agattctact gaagaaaggt agccatggaa gagaatatgg aagagggaca gacacaaaaa    840

gggtgttttg aatgctgtat caaatgcctg gggggcattc cctatgcctc tctgattgcc    900

accatcctgc tctatgcggg tgttgccctg ttctgtggct gcggtcatga agcgctttct    960

ggaactgtca acattctgca aacctacttt gagatggcaa gaactgctgg agacacactg   1020

gatgttttta ccatgattga catctttaag tatgtgatct acggcatcgc agctgcgttc   1080

tttgtgtatg gcattttgct gatggtggaa ggtttcttca caactggggc catcaaagat   1140

ctctatgggg atttcaaaat caccacttgt ggcagatgtg tgagcgcttg gttcattatg   1200

ctgacatatc ttttcatgtt ggcctggctg ggagtcacgg ctttcacctc actgccagtt   1260

tacatgtact tcaatctgtg gaccatctgc cggaacacca cattagtgga gggagcaaat   1320

ctctgcttgg accttcgtca gtttggaatt gtgacaattg gagaggaaaa gaaaatttgt   1380

actgtctctg agaatttctt gaggatgtgc gaatctactg agctgaacat gaccttccac   1440

ttgtttattg tggcacttgc tggagctggg gcagcagtca ttgctatggt tcactacctt   1500

atggttctgt ctgccaactg ggcctatgtg aaagacgcct gccggatgca gaagtatgaa   1560

gacatcaagt cgaaggaaga gcaagagctt catgacatcc actctactcg ctccaaagag   1620

cggctcaatg catacacata aatgcatctt cctgttcttt ctaccatttg aatgcattgg   1680

tgtttaacta agggccatcc aaccatccaa cctttaaaaa acaaaacgaa agtgcttctc   1740

atcaatgata tgtaaggtga cttatgaatc acctgagtac aattctttgt tgtttagcac   1800

ttaaatttcc caatttatta aattgatgta aatcagatct tttctacaag ctcctatcca   1860

gccttttttt tgaaatttct caaactcatt tactagttct gtaaaatcaa agatactaac   1920

attgtcaaat gcaaagattt gtttgatttt taaccacttc ccatgtgtta tacataacac   1980

cttttgcatt atttcttatg ttttgaaaag aaaatagctt tttatacttt ttagttttga   2040

tttcggtaac tagtttaact acaggtaacc ttcaaaggga ccattgtaca ttatgaacaa   2100

tagatagaga ttacatcttg atgactcttg aaatatggaa attttgtctg aagatcagtg   2160

gccatattac tgtaggccct ggttcatgtt ttcatcaatc taaggtgcaa tttctaaatt   2220

tgtaagagta ggtttaaaaa aaaaagtgct tcttatcttt gttaacattg tacttttcct   2280

tgatgttctt aaaaggtatt tccctcagat tactcatgtt tatgttgtga gcatgtagaa   2340

acagtaatgc taatgcatgg ctagttgcct ttttaagatt gtgacaccag gcttaccttt   2400

taaagtttag tatatagaga caattttaat ggaaataact actgtagact attgaagaat   2460

gatctctttg tgatttaaga agtggctgga ttggaacttt taatatgcta atgtggaaaa   2520

ttaattacct ttatgaaggt ggtttattac aaataagcac actaacccct cggaagttgt   2580

tttacctact ttaaaagttt taatggattg cacctctgta aactattcct aaaatgtgta   2640

tgatatattt gaaaaggctt ccattaatat aatagctttg cttgcagcct tccaatctat   2700

gttggtttac ctgtagtgtt ttataaagtg tggtcagagg cccctataga atgtattgtt   2760

tgaaagtgta gtgatatatt tgtgttttta tttcaagtaa gtcattttaa ccgaatgttc   2820

attcatattc atttataaaa agtacctgta tcaaaggaat tttaacaaag agcaatcagt   2880

attattggac caaatttggt gtttgttttc accttgacgc tcttcttttc attatttcta   2940

atgctacaag aatgctgtaa agtgtcttct aaaatgatgt agcctgacaa gacatttttt   3000

tcagtgtata aaactaggta gtattgtgca ctgatttgac cattgtgaaa tcctttctca   3060

gtgtaactgc atttctaata aaaatttatt gagtgaaaca atctttgtac aatgactagt   3120

catgcatcat cagtaatttt acaagttctt gtagtaggta gggggtacta ctagggatat   3180

ctgtggcatg attatgcatt ccgtagtatt atttaattaa tttggggttc attttgcttc   3240

cttttcttta tgcttagatt atcttactgg ttcaacattt ttctgatata tgcagtatta   3300

cagatattca gcaaaagtat taatgggctt ctttaaattc tatattatag tatttcagtt   3360

ccgtgtctta acagtttgtg ataatttcta aaactgtctt ttcaacttat gtaatgatgt   3420

tgacactttt ggcttttatt tctggtatta gagtttgtat tttcacagag tgctttgtag   3480

caggcattac aattaatctg ttttgtacat aaatgtgcca acagcttgat ggtggcgttt   3540

ttgaaatgta gaacagagtg cttgcaaaat gtaataaata cacttgtgta ctttgtgtac   3600

ttattattaa aaaa                                                     3614


<210>  954
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  954

Met Glu Glu Asn Met Glu Glu Gly Gln Thr Gln Lys Gly Cys Phe Glu 
1               5                   10                  15      


Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr Ala Ser Leu Ile Ala 
            20                  25                  30          


Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe Cys Gly Cys Gly His 
        35                  40                  45              


Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln Thr Tyr Phe Glu Met 
    50                  55                  60                  


Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr Met Ile Asp Ile 
65                  70                  75                  80  


Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala Phe Phe Val Tyr Gly 
                85                  90                  95      


Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr Gly Ala Ile Lys Asp 
            100                 105                 110         


Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly Arg Cys Val Ser Ala 
        115                 120                 125             


Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu Ala Trp Leu Gly Val 
    130                 135                 140                 


Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr Phe Asn Leu Trp Thr 
145                 150                 155                 160 


Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala Asn Leu Cys Leu Asp 
                165                 170                 175     


Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu Glu Lys Lys Ile Cys 
            180                 185                 190         


Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu Ser Thr Glu Leu Asn 
        195                 200                 205             


Met Thr Phe His Leu Phe Ile Val Ala Leu Ala Gly Ala Gly Ala Ala 
    210                 215                 220                 


Val Ile Ala Met Val His Tyr Leu Met Val Leu Ser Ala Asn Trp Ala 
225                 230                 235                 240 


Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr Glu Asp Ile Lys Ser 
                245                 250                 255     


Lys Glu Glu Gln Glu Leu His Asp Ile His Ser Thr Arg Ser Lys Glu 
            260                 265                 270         


Arg Leu Asn Ala Tyr Thr 
        275             


<210>  955
<211>  2962
<212>  DNA
<213>  Homosapiens

<400>  955
aagagggagg ggtctgtgcg cccgcagagt cgccaggcgc cctgcgagtt gtctccgctg     60

ggaggggcga ggctgtcact tgccagggcg cgaggagcct cagcgcggct tggagaactt    120

ggccccgcgc agcgtctggt cactcgctct cctctgggga ctgcagagaa gcaggacctc    180

gggccatggg gtgttttgaa tgctgtatca aatgcctggg gggcattccc tatgcctctc    240

tgattgccac catcctgctc tatgcgggtg ttgccctgtt ctgtggctgc ggtcatgaag    300

cgctttctgg aactgtcaac attctgcaaa cctactttga gatggcaaga actgctggag    360

acacactgga tgtttttacc atgattgaca tctttaagta tgtgatctac ggcatcgcag    420

ctgcgttctt tgtgtatggc attttgctga tggtggaagg tttcttcaca actggggcca    480

tcaaagatct ctatggggat ttcaaaatca ccacttgtgg cagatgtgtg agcgcttggt    540

tcattatgct gacatatctt ttcatgttgg cctggctggg agtcacggct ttcacctcac    600

tgccagttta catgtacttc aatctgtgga ccatctgccg gaacaccaca ttagtggagg    660

gagcaaatct ctgcttggac cttcgtcagt ttggaattgt gacaattgga gaggaaaaga    720

aaatttgtac tgtctctgag aatttcttga ggatgtgcga atctactgag ctgaacatga    780

ccttccactt gtttattgtg gcacttgctg gagctggggc agcagtcatt gctatggttc    840

actaccttat ggttctgtct gccaactggg cctatgtgaa agacgcctgc cggatgcaga    900

agtatgaaga catcaagtcg aaggaagagc aagagcttca tgacatccac tctactcgct    960

ccaaagagcg gctcaatgca tacacataaa tgcatcttcc tgttctttct accatttgaa   1020

tgcattggtg tttaactaag ggccatccaa ccatccaacc tttaaaaaac aaaacgaaag   1080

tgcttctcat caatgatatg taaggtgact tatgaatcac ctgagtacaa ttctttgttg   1140

tttagcactt aaatttccca atttattaaa ttgatgtaaa tcagatcttt tctacaagct   1200

cctatccagc cttttttttg aaatttctca aactcattta ctagttctgt aaaatcaaag   1260

atactaacat tgtcaaatgc aaagatttgt ttgattttta accacttccc atgtgttata   1320

cataacacct tttgcattat ttcttatgtt ttgaaaagaa aatagctttt tatacttttt   1380

agttttgatt tcggtaacta gtttaactac aggtaacctt caaagggacc attgtacatt   1440

atgaacaata gatagagatt acatcttgat gactcttgaa atatggaaat tttgtctgaa   1500

gatcagtggc catattactg taggccctgg ttcatgtttt catcaatcta aggtgcaatt   1560

tctaaatttg taagagtagg tttaaaaaaa aaagtgcttc ttatctttgt taacattgta   1620

cttttccttg atgttcttaa aaggtatttc cctcagatta ctcatgttta tgttgtgagc   1680

atgtagaaac agtaatgcta atgcatggct agttgccttt ttaagattgt gacaccaggc   1740

ttacctttta aagtttagta tatagagaca attttaatgg aaataactac tgtagactat   1800

tgaagaatga tctctttgtg atttaagaag tggctggatt ggaactttta atatgctaat   1860

gtggaaaatt aattaccttt atgaaggtgg tttattacaa ataagcacac taacccctcg   1920

gaagttgttt tacctacttt aaaagtttta atggattgca cctctgtaaa ctattcctaa   1980

aatgtgtatg atatatttga aaaggcttcc attaatataa tagctttgct tgcagccttc   2040

caatctatgt tggtttacct gtagtgtttt ataaagtgtg gtcagaggcc cctatagaat   2100

gtattgtttg aaagtgtagt gatatatttg tgtttttatt tcaagtaagt cattttaacc   2160

gaatgttcat tcatattcat ttataaaaag tacctgtatc aaaggaattt taacaaagag   2220

caatcagtat tattggacca aatttggtgt ttgttttcac cttgacgctc ttcttttcat   2280

tatttctaat gctacaagaa tgctgtaaag tgtcttctaa aatgatgtag cctgacaaga   2340

catttttttc agtgtataaa actaggtagt attgtgcact gatttgacca ttgtgaaatc   2400

ctttctcagt gtaactgcat ttctaataaa aatttattga gtgaaacaat ctttgtacaa   2460

tgactagtca tgcatcatca gtaattttac aagttcttgt agtaggtagg gggtactact   2520

agggatatct gtggcatgat tatgcattcc gtagtattat ttaattaatt tggggttcat   2580

tttgcttcct tttctttatg cttagattat cttactggtt caacattttt ctgatatatg   2640

cagtattaca gatattcagc aaaagtatta atgggcttct ttaaattcta tattatagta   2700

tttcagttcc gtgtcttaac agtttgtgat aatttctaaa actgtctttt caacttatgt   2760

aatgatgttg acacttttgg cttttatttc tggtattaga gtttgtattt tcacagagtg   2820

ctttgtagca ggcattacaa ttaatctgtt ttgtacataa atgtgccaac agcttgatgg   2880

tggcgttttt gaaatgtaga acagagtgct tgcaaaatgt aataaataca cttgtgtact   2940

ttgtgtactt attattaaaa aa                                            2962


<210>  956
<211>  267
<212>  PRT
<213>  Homosapiens

<400>  956

Met Gly Cys Phe Glu Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr 
1               5                   10                  15      


Ala Ser Leu Ile Ala Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln 
        35                  40                  45              


Thr Tyr Phe Glu Met Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe 
    50                  55                  60                  


Thr Met Ile Asp Ile Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala 
65                  70                  75                  80  


Phe Phe Val Tyr Gly Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr 
                85                  90                  95      


Gly Ala Ile Lys Asp Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly 
            100                 105                 110         


Arg Cys Val Ser Ala Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu 
        115                 120                 125             


Ala Trp Leu Gly Val Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr 
    130                 135                 140                 


Phe Asn Leu Trp Thr Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala 
145                 150                 155                 160 


Asn Leu Cys Leu Asp Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu 
                165                 170                 175     


Glu Lys Lys Ile Cys Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu 
            180                 185                 190         


Ser Thr Glu Leu Asn Met Thr Phe His Leu Phe Ile Val Ala Leu Ala 
        195                 200                 205             


Gly Ala Gly Ala Ala Val Ile Ala Met Val His Tyr Leu Met Val Leu 
    210                 215                 220                 


Ser Ala Asn Trp Ala Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr 
225                 230                 235                 240 


Glu Asp Ile Lys Ser Lys Glu Glu Gln Glu Leu His Asp Ile His Ser 
                245                 250                 255     


Thr Arg Ser Lys Glu Arg Leu Asn Ala Tyr Thr 
            260                 265         


<210>  957
<211>  7378
<212>  DNA
<213>  Homosapiens

<400>  957
gcggggaggg tccgcgcgtt ggtggtgctc gcctcgcagc tgcgcccgcc ggcttcagca     60

ccttccgctg tccgccgctg cagccgcctc ctcctccagg tgctgactat tctgatgccg    120

agtttccaat tgccttgatt aaagtagaaa cattctatgg cttggatgac ttacatttca    180

aattggtttg agcaagatga ttggtatgaa ggactacaaa gagcaaacat gtcccaggta    240

aggcaagtgg gattgctggc tgctggatgt cagccatgga acaaggatgt atgtgctgcc    300

agtggagaca ggtttgcata ttgtgcgacc ctggctatct atatttatca gttggatcac    360

cgttataatg aattcaaact tcacgcaatt atgtctgaac ataaaaaaac aatcacagca    420

atttcttggt gtccacataa tcctgatctg tttgcaagtg gcagtactga taatttagtg    480

atcatttgga atgttgcaga acaaaaagtc attgctaaac tcgacagtac aaaagggatc    540

cctgcttctc ttagttggtg ctggaatgca gaggatgtgg tggcatttgt ttcccacaga    600

ggcccactgt tcatttggac catctcagga ccagatagtg gagtgattgt acacaaagat    660

gctcatagct tcttgtctga tatctgtatg ttcagatggc atacacacca aaaggggaaa    720

gttgtgtttg gtcatattga tggaagtcta tcaatttttc atccaggtaa taaaaatcag    780

aaacatgttt tgagaccaga atctcttgaa gggacagatg aagaggatcc agttacggcc    840

ttggaatggg acccactatc tactgattat cttctagtgg ttaatttgca ttatggaatt    900

cgcctggtag attctgaatc actttcttgc ataacaacat ttaatcttcc cagtgcagca    960

gcttctgtac agtgcttagc ctgggttccc agtgctcctg ggatgtttat aactggagat   1020

tctcaagtgg gtgttttacg catttggaat gtttcaagaa caacacctat tgataatctt   1080

aaattaaaga aaacaggatt tcactgctta catgtactta attctcctcc aagaaaaaag   1140

ttttcagtcc aatctccaac caaaaatcat tatacatcct caacaagcga agcagttcca   1200

cccccaactt taacacagaa tcaagcattt tctcttcctc ctggtcatgc agtgtgttgt   1260

ttcttggatg gtggagttgg actttatgat atgggagcta agaagtggga ttttcttaga   1320

gacttgggac atgtggaaac tatctttgac tgcaaattca aacctgacga tcctaatctt   1380

ttagcaacag cttcatttga tggcactata aaagtctggg atataaacac attaacagca   1440

gtgtacacat ccccgggtaa tgaaggtgtt atttattccc tttcttgggc tccaggtggt   1500

ttaaattgta ttgctggggg aacttcccga aatggtgctt ttatttggaa tgttcaaaag   1560

ggcaaaatta tacaacgatt taatgagcat ggaacaaatg gaatattctg cattgcctgg   1620

agtcataaag attctaaaag aatagcaacc tgcagcagtg atggtttctg tattattcga   1680

acaattgatg gtaaagtgct acacaaatat aaacatccag ctgcagtgtt tggttgtgat   1740

tggagccaaa acaataaaga catgatagcc actggctgtg aagacacaaa tgttcgtgtt   1800

tattatgtag ccaccagctc agatcaacca ttgaaagtat ttagtgggca tacagcaaaa   1860

gtgtttcatg ttaaatggtc tcctctgaga gagggaattc tttgcagtgg ttctgatgat   1920

ggtaccgttc gaatctggga ttatactcag gatgcttgca tcaatattct taatggacac   1980

actgcacctg tgagaggatt aatgtggaat actgagattc catatctgct catatctggc   2040

agctgggact atactataaa agtatgggac actcgagaag gaacttgtgt ggatactgtg   2100

tatgatcacg gtgcagatgt atatggttta acctgccatc ccagtcgccc cttcactatg   2160

gcctcttgct cccgtgactc tacagtgaga ctctggtcat taacagcctt agtcactcct   2220

gtacaaataa atattctggc agacagatct tgggaagaaa ttattgggaa cactgattat   2280

gctatagaac caggcactcc tcctctactg tgtggtaaag tgtcaagaga tattagacag   2340

gaaatagaaa aactaactgc taattctcaa gtgaaaaaac taagatggtt ctcagaatgt   2400

ttatctcctc caggtggcag tgacaattta tggaacttgg ttgctgtgat aaaaggacag   2460

gatgatagct tacttcctca gaactactgc aaaggaataa tgcacttgaa acatctgatt   2520

aaatttagaa catctgaagc tcaagaacta acaacagtca agatgtctaa atttggtggt   2580

ggtattggtg tacctgctaa agaggaaaga ctgaaggaag ctgctgaaat ccacttgaga   2640

ttaggacaaa ttcagagata ctgtgaactt atggttgaac ttggagagtg ggacaaagcc   2700

ctgtcaattg caccaggagt ctctgtgaaa tactggaaga agttaatgca gaggagagct   2760

gaccaattaa tccaggaaga taaggatgat gtcattccat actgcatagc cattggtgat   2820

gtgaaaaagc tagtccattt tttcatgtca agaggtcagc ttaaagaagc tctgcttgtt   2880

gcacaggctg cttgtgaagg aaatatgcag cccttacatg tttccgtgcc taaaggagct   2940

tcatattctg atgatatcta caaggaagac tttaatgaac tcctgcacaa agtcagtaaa   3000

gaactggcag aatggtattt tcaagatggt cgagcagtac tagccgcatg ttgccatctt   3060

gccatagata atattgagct tgctatggca tacctgattc gcggaaatga actggagttg   3120

gcagtctgtg tgggcacagt actaggagag tctgcagcac cagcaaccca ctatgcctta   3180

gaattactgg cgagaaagtg catgatgatt tcagtatgct ttccatgtgt tggatacagt   3240

gtcccctttt gttacgttaa caggaatttg gcagctgatc ttcttctgat gattcctgat   3300

aatgaactac atttaataaa actctgtgct ttctacccag gatgtactga agagataaat   3360

gaccttcatg ataagtgtaa gctacccaca gtggaagaat gtatgcagtt agctgagaca   3420

gcccgtgcag atgacaatat atttgaaact gtaaaatatt acttgttaag tcaagaacct   3480

gaaaaagccc ttcctattgg tattagcttt gttaaagaat acatcagtag ctcagactgg   3540

actttggata ccatataccc tgttcttgac ctactgagct atattcgtac tgaaaaatta   3600

ctcttgcata cgtgtactga agctcgaaat gagttgctga tattatgtgg ttacattggt   3660

gcattactgg ctatcagaag acagtaccaa agcattgttc cagcacttta tgagtacaca   3720

agtcagctat taaaacgtcg ggaggtgtca gtacctttaa aaattgaata tctttctgag   3780

gaattggatg catggagagc ttgcacacag tccaccaaca gatcattaga agactctccg   3840

tatacacccc cttctgattc acaaagaatg atttatgcaa ctttattaaa gagactaaaa   3900

gaagagtcac tgaaaggaat tattggacca gattatgtga ctggatcaaa tcttccaagt   3960

cattctgata ttcacatttc ttgtcttacg ggattaaaaa tccagggccc tgtgtttttc   4020

cttgaagacg ggaaatctgc tatctccttg aatgatgctt tgatgtgggc aaaggtgaat   4080

ccattctcac ctttagggac tggaatacga ctcaatccat tctgatagaa gatttttgtc   4140

catgcttgat tttttttttt aaagaaaaac tttcatgggt tagcattacc ttaatctttg   4200

ttgctcaagt gccagaggtt gggagaagga ttgcaggttg ggagaggtgg gaaatagcag   4260

tgaattttag tcattaactt caaaatatat atatatatat aatttaaagg aaaaataggt   4320

gcctccttta taaacagtaa tagctacgtt tgggaaggag gaaacattta aattataaag   4380

gactgaataa tctaaaaagc atataaaagt ttcacacagc ataaaagata ccaaaatatc   4440

atatggttga aatattgaaa catattaaat tgtgcaacac ctagaatagt gctagacata   4500

cagtaagtac ttaatggata tttgaatgat tgaatatctt gaaatgttga aatgtaaggt   4560

gtgcacagtg atcttcaact taacaaacac ttacgttctc ctttataaaa tgcatagtaa   4620

accactaacg ttagctgttt taataaaagt tttcagttat aagtttagta aatattaata   4680

aatggataca cattcaaaat acttttaaaa aaaagaaaat gttaccagtt tttttatctg   4740

aagtttaact gtcccattgt aaaggtgtaa gttatatagg cttgaaaaaa attggcgggt   4800

aaaaatcaca aaatgcagtc gaatatatat atgaaaactt gcattaggtg ataaagtgac   4860

tattttaaga gattcagcat gcatggatat tagttttgat taatgtgtac aataatttac   4920

acagtatact ctagtcaatt tatgttaact ttatttaaaa cacaatttat ttggccgggc   4980

acggtggctc acacctgtaa tctcagcact ttggcaggcc aaggcaggtg gatcacctga   5040

ggtcaggagt tcatgaccag cctggccagc atggtaaaac cctgtctcca ctaaaaatac   5100

aaaaattagc caggcatggt ggcgggcacc tgtaatccca gttacttggg aagctgaggc   5160

aggagaatcc cttgaacctg ggaggcagag gttccagtga gccaagatcg caccactgca   5220

ctccagcctg ggcaacaaag agcgaaactc tgtctcaaaa aacaaaccaa caaaaaccac   5280

aattgatttg atgaaaatta gttttaagta aatgtttgta aatagatatt ggttgaattt   5340

ttggatatat tatgttgatt taacttttaa aatgttgttt aaaagtgtga agctatgaaa   5400

agcctgataa tgtgactaca gatatttcag ttggactaga attctgactt tgaaacttat   5460

taaattaatg catactggaa gtactttgat actcaagttg tttcacaaga tttataatat   5520

agatggtttt gtttgactaa agaataatct catataacta gaatacttgt ggcttttatt   5580

atctttaaac ttgttgcatt taaaatattt ttaaaacctt cttaacaaaa cttcttaaaa   5640

ctggaaaaaa tatatattat gtatctatgt atcatattta tcacatgacc acttttgatt   5700

ccttaaaaag acattacagg cttaaattcc attttattaa aaaaaaaaaa ttgcctgtaa   5760

tcccagcact tcaggaggcc gagatgggca gatcttgagg tcggtagatg gagaccatcc   5820

tggccaacat ggtgaaaccc tgtctctact aaaaatacaa aaattagctg ggtgtggtgg   5880

tgtgtacctg tagtcccagc tacccaggaa gctaaggcag gagaatcgct tgaatccagg   5940

aggcggaggt tgcagtgagc tgagatcgca ctactgcact ccagcctggg cgacagagca   6000

agaccaccat ctccaaaaat tatatatata aaaataatta atattataga agagaatata   6060

cacaactcag agatgcaatg gataatataa aaagagtacc tgagatgtat ttttttaaac   6120

tcttagagat atctgtaact caaatttttc ttaggtgagg aggattatta actggcacat   6180

atgtactaaa aacccctcac ttaaaaatgg cagtctcaat cctactgtca ttctttttat   6240

tttaaaataa ataaataagc ctatcttttt gtgcttacat acttaaaagg atatcattaa   6300

gtatataaac aatcattact tctgtatttt taatgaatgc aggaaaataa tatttttatg   6360

tataaaagat gaagaaaaaa ttttgcaagt ctttaagcac ataaatacaa cagaatagcc   6420

acccaatttc tgtctgaaat ctaaattgga tggatttgac catcattcta ttatctttga   6480

tttctacaat gtctatatct tattacctat aactattaat ttttcataga attataaatg   6540

tcatttgact atgtcaatct gtatatattg taccttaata tgaaaaacaa attttttaat   6600

tcataaaagt atttttatta gatttcatat gcatgaaacc caagcaaatt atatgaattt   6660

attttactat ttgaaaatgt tcatattacc aataatgtgg acaaattact ttgcaggttt   6720

aaatatgcct ctgtaaagga agagtctcat tagacaatga tttttaaagc attggaaaaa   6780

tattttgcct gtaaaagtta gtaactaggt ggttcacaaa attacaacat caaaatagtt   6840

acatcttgtg aaaatatatg atttttatgt caatcaagac aaatgaaata tatatgtatg   6900

tgtatatata tacatgtatg tatgaaatat atatatgtgc gtgtgtgtgt gtatatatat   6960

atatatatat atatatttct atgaaattgt ccagatgtgt tcaggaacat gattgcatta   7020

gagcaatgac tgtattttgt tgtccttata acatttatat tatttcagtt ttaagtcaaa   7080

aggtattctg aatataataa aagcctcaca aattatttgt aaaatttagt agttcatatt   7140

tagtatatca gtaatataga agacatcttt atagtcaact cttaattaat gcttattgta   7200

ccaaatcttt gagatatttg tacataaatg aaatatgtac tttcatgcta aaattatata   7260

tcatgactgt gctataattt ggcatgtcat tatctagatt tatatgtatg tacgtatttc   7320

aggtccttga aattttaata aatattacag ttaaatcctg aaaaaaaaaa aaaaaaaa     7378


<210>  958
<211>  1322
<212>  PRT
<213>  Homosapiens

<400>  958

Met Ala Trp Met Thr Tyr Ile Ser Asn Trp Phe Glu Gln Asp Asp Trp 
1               5                   10                  15      


Tyr Glu Gly Leu Gln Arg Ala Asn Met Ser Gln Val Arg Gln Val Gly 
            20                  25                  30          


Leu Leu Ala Ala Gly Cys Gln Pro Trp Asn Lys Asp Val Cys Ala Ala 
        35                  40                  45              


Ser Gly Asp Arg Phe Ala Tyr Cys Ala Thr Leu Ala Ile Tyr Ile Tyr 
    50                  55                  60                  


Gln Leu Asp His Arg Tyr Asn Glu Phe Lys Leu His Ala Ile Met Ser 
65                  70                  75                  80  


Glu His Lys Lys Thr Ile Thr Ala Ile Ser Trp Cys Pro His Asn Pro 
                85                  90                  95      


Asp Leu Phe Ala Ser Gly Ser Thr Asp Asn Leu Val Ile Ile Trp Asn 
            100                 105                 110         


Val Ala Glu Gln Lys Val Ile Ala Lys Leu Asp Ser Thr Lys Gly Ile 
        115                 120                 125             


Pro Ala Ser Leu Ser Trp Cys Trp Asn Ala Glu Asp Val Val Ala Phe 
    130                 135                 140                 


Val Ser His Arg Gly Pro Leu Phe Ile Trp Thr Ile Ser Gly Pro Asp 
145                 150                 155                 160 


Ser Gly Val Ile Val His Lys Asp Ala His Ser Phe Leu Ser Asp Ile 
                165                 170                 175     


Cys Met Phe Arg Trp His Thr His Gln Lys Gly Lys Val Val Phe Gly 
            180                 185                 190         


His Ile Asp Gly Ser Leu Ser Ile Phe His Pro Gly Asn Lys Asn Gln 
        195                 200                 205             


Lys His Val Leu Arg Pro Glu Ser Leu Glu Gly Thr Asp Glu Glu Asp 
    210                 215                 220                 


Pro Val Thr Ala Leu Glu Trp Asp Pro Leu Ser Thr Asp Tyr Leu Leu 
225                 230                 235                 240 


Val Val Asn Leu His Tyr Gly Ile Arg Leu Val Asp Ser Glu Ser Leu 
                245                 250                 255     


Ser Cys Ile Thr Thr Phe Asn Leu Pro Ser Ala Ala Ala Ser Val Gln 
            260                 265                 270         


Cys Leu Ala Trp Val Pro Ser Ala Pro Gly Met Phe Ile Thr Gly Asp 
        275                 280                 285             


Ser Gln Val Gly Val Leu Arg Ile Trp Asn Val Ser Arg Thr Thr Pro 
    290                 295                 300                 


Ile Asp Asn Leu Lys Leu Lys Lys Thr Gly Phe His Cys Leu His Val 
305                 310                 315                 320 


Leu Asn Ser Pro Pro Arg Lys Lys Phe Ser Val Gln Ser Pro Thr Lys 
                325                 330                 335     


Asn His Tyr Thr Ser Ser Thr Ser Glu Ala Val Pro Pro Pro Thr Leu 
            340                 345                 350         


Thr Gln Asn Gln Ala Phe Ser Leu Pro Pro Gly His Ala Val Cys Cys 
        355                 360                 365             


Phe Leu Asp Gly Gly Val Gly Leu Tyr Asp Met Gly Ala Lys Lys Trp 
    370                 375                 380                 


Asp Phe Leu Arg Asp Leu Gly His Val Glu Thr Ile Phe Asp Cys Lys 
385                 390                 395                 400 


Phe Lys Pro Asp Asp Pro Asn Leu Leu Ala Thr Ala Ser Phe Asp Gly 
                405                 410                 415     


Thr Ile Lys Val Trp Asp Ile Asn Thr Leu Thr Ala Val Tyr Thr Ser 
            420                 425                 430         


Pro Gly Asn Glu Gly Val Ile Tyr Ser Leu Ser Trp Ala Pro Gly Gly 
        435                 440                 445             


Leu Asn Cys Ile Ala Gly Gly Thr Ser Arg Asn Gly Ala Phe Ile Trp 
    450                 455                 460                 


Asn Val Gln Lys Gly Lys Ile Ile Gln Arg Phe Asn Glu His Gly Thr 
465                 470                 475                 480 


Asn Gly Ile Phe Cys Ile Ala Trp Ser His Lys Asp Ser Lys Arg Ile 
                485                 490                 495     


Ala Thr Cys Ser Ser Asp Gly Phe Cys Ile Ile Arg Thr Ile Asp Gly 
            500                 505                 510         


Lys Val Leu His Lys Tyr Lys His Pro Ala Ala Val Phe Gly Cys Asp 
        515                 520                 525             


Trp Ser Gln Asn Asn Lys Asp Met Ile Ala Thr Gly Cys Glu Asp Thr 
    530                 535                 540                 


Asn Val Arg Val Tyr Tyr Val Ala Thr Ser Ser Asp Gln Pro Leu Lys 
545                 550                 555                 560 


Val Phe Ser Gly His Thr Ala Lys Val Phe His Val Lys Trp Ser Pro 
                565                 570                 575     


Leu Arg Glu Gly Ile Leu Cys Ser Gly Ser Asp Asp Gly Thr Val Arg 
            580                 585                 590         


Ile Trp Asp Tyr Thr Gln Asp Ala Cys Ile Asn Ile Leu Asn Gly His 
        595                 600                 605             


Thr Ala Pro Val Arg Gly Leu Met Trp Asn Thr Glu Ile Pro Tyr Leu 
    610                 615                 620                 


Leu Ile Ser Gly Ser Trp Asp Tyr Thr Ile Lys Val Trp Asp Thr Arg 
625                 630                 635                 640 


Glu Gly Thr Cys Val Asp Thr Val Tyr Asp His Gly Ala Asp Val Tyr 
                645                 650                 655     


Gly Leu Thr Cys His Pro Ser Arg Pro Phe Thr Met Ala Ser Cys Ser 
            660                 665                 670         


Arg Asp Ser Thr Val Arg Leu Trp Ser Leu Thr Ala Leu Val Thr Pro 
        675                 680                 685             


Val Gln Ile Asn Ile Leu Ala Asp Arg Ser Trp Glu Glu Ile Ile Gly 
    690                 695                 700                 


Asn Thr Asp Tyr Ala Ile Glu Pro Gly Thr Pro Pro Leu Leu Cys Gly 
705                 710                 715                 720 


Lys Val Ser Arg Asp Ile Arg Gln Glu Ile Glu Lys Leu Thr Ala Asn 
                725                 730                 735     


Ser Gln Val Lys Lys Leu Arg Trp Phe Ser Glu Cys Leu Ser Pro Pro 
            740                 745                 750         


Gly Gly Ser Asp Asn Leu Trp Asn Leu Val Ala Val Ile Lys Gly Gln 
        755                 760                 765             


Asp Asp Ser Leu Leu Pro Gln Asn Tyr Cys Lys Gly Ile Met His Leu 
    770                 775                 780                 


Lys His Leu Ile Lys Phe Arg Thr Ser Glu Ala Gln Glu Leu Thr Thr 
785                 790                 795                 800 


Val Lys Met Ser Lys Phe Gly Gly Gly Ile Gly Val Pro Ala Lys Glu 
                805                 810                 815     


Glu Arg Leu Lys Glu Ala Ala Glu Ile His Leu Arg Leu Gly Gln Ile 
            820                 825                 830         


Gln Arg Tyr Cys Glu Leu Met Val Glu Leu Gly Glu Trp Asp Lys Ala 
        835                 840                 845             


Leu Ser Ile Ala Pro Gly Val Ser Val Lys Tyr Trp Lys Lys Leu Met 
    850                 855                 860                 


Gln Arg Arg Ala Asp Gln Leu Ile Gln Glu Asp Lys Asp Asp Val Ile 
865                 870                 875                 880 


Pro Tyr Cys Ile Ala Ile Gly Asp Val Lys Lys Leu Val His Phe Phe 
                885                 890                 895     


Met Ser Arg Gly Gln Leu Lys Glu Ala Leu Leu Val Ala Gln Ala Ala 
            900                 905                 910         


Cys Glu Gly Asn Met Gln Pro Leu His Val Ser Val Pro Lys Gly Ala 
        915                 920                 925             


Ser Tyr Ser Asp Asp Ile Tyr Lys Glu Asp Phe Asn Glu Leu Leu His 
    930                 935                 940                 


Lys Val Ser Lys Glu Leu Ala Glu Trp Tyr Phe Gln Asp Gly Arg Ala 
945                 950                 955                 960 


Val Leu Ala Ala Cys Cys His Leu Ala Ile Asp Asn Ile Glu Leu Ala 
                965                 970                 975     


Met Ala Tyr Leu Ile Arg Gly Asn Glu Leu Glu Leu Ala Val Cys Val 
            980                 985                 990         


Gly Thr Val Leu Gly Glu Ser Ala  Ala Pro Ala Thr His  Tyr Ala Leu 
        995                 1000                 1005             


Glu Leu  Leu Ala Arg Lys Cys  Met Met Ile Ser Val  Cys Phe Pro 
    1010                 1015                 1020             


Cys Val  Gly Tyr Ser Val Pro  Phe Cys Tyr Val Asn  Arg Asn Leu 
    1025                 1030                 1035             


Ala Ala  Asp Leu Leu Leu Met  Ile Pro Asp Asn Glu  Leu His Leu 
    1040                 1045                 1050             


Ile Lys  Leu Cys Ala Phe Tyr  Pro Gly Cys Thr Glu  Glu Ile Asn 
    1055                 1060                 1065             


Asp Leu  His Asp Lys Cys Lys  Leu Pro Thr Val Glu  Glu Cys Met 
    1070                 1075                 1080             


Gln Leu  Ala Glu Thr Ala Arg  Ala Asp Asp Asn Ile  Phe Glu Thr 
    1085                 1090                 1095             


Val Lys  Tyr Tyr Leu Leu Ser  Gln Glu Pro Glu Lys  Ala Leu Pro 
    1100                 1105                 1110             


Ile Gly  Ile Ser Phe Val Lys  Glu Tyr Ile Ser Ser  Ser Asp Trp 
    1115                 1120                 1125             


Thr Leu  Asp Thr Ile Tyr Pro  Val Leu Asp Leu Leu  Ser Tyr Ile 
    1130                 1135                 1140             


Arg Thr  Glu Lys Leu Leu Leu  His Thr Cys Thr Glu  Ala Arg Asn 
    1145                 1150                 1155             


Glu Leu  Leu Ile Leu Cys Gly  Tyr Ile Gly Ala Leu  Leu Ala Ile 
    1160                 1165                 1170             


Arg Arg  Gln Tyr Gln Ser Ile  Val Pro Ala Leu Tyr  Glu Tyr Thr 
    1175                 1180                 1185             


Ser Gln  Leu Leu Lys Arg Arg  Glu Val Ser Val Pro  Leu Lys Ile 
    1190                 1195                 1200             


Glu Tyr  Leu Ser Glu Glu Leu  Asp Ala Trp Arg Ala  Cys Thr Gln 
    1205                 1210                 1215             


Ser Thr  Asn Arg Ser Leu Glu  Asp Ser Pro Tyr Thr  Pro Pro Ser 
    1220                 1225                 1230             


Asp Ser  Gln Arg Met Ile Tyr  Ala Thr Leu Leu Lys  Arg Leu Lys 
    1235                 1240                 1245             


Glu Glu  Ser Leu Lys Gly Ile  Ile Gly Pro Asp Tyr  Val Thr Gly 
    1250                 1255                 1260             


Ser Asn  Leu Pro Ser His Ser  Asp Ile His Ile Ser  Cys Leu Thr 
    1265                 1270                 1275             


Gly Leu  Lys Ile Gln Gly Pro  Val Phe Phe Leu Glu  Asp Gly Lys 
    1280                 1285                 1290             


Ser Ala  Ile Ser Leu Asn Asp  Ala Leu Met Trp Ala  Lys Val Asn 
    1295                 1300                 1305             


Pro Phe  Ser Pro Leu Gly Thr  Gly Ile Arg Leu Asn  Pro Phe 
    1310                 1315                 1320         


<210>  959
<211>  7255
<212>  DNA
<213>  Homosapiens

<400>  959
gcggggaggg tccgcgcgtt ggtggtgctc gcctcgcagc tgcgcccgcc ggcttcagca     60

ccttccgctg tccgccgctg cagccgcctc ctcctccagg caaacatgtc ccaggtaagg    120

caagtgggat tgctggctgc tggatgtcag ccatggaaca aggatgtatg tgctgccagt    180

ggagacaggt ttgcatattg tgcgaccctg gctatctata tttatcagtt ggatcaccgt    240

tataatgaat tcaaacttca cgcaattatg tctgaacata aaaaaacaat cacagcaatt    300

tcttggtgtc cacataatcc tgatctgttt gcaagtggca gtactgataa tttagtgatc    360

atttggaatg ttgcagaaca aaaagtcatt gctaaactcg acagtacaaa agggatccct    420

gcttctctta gttggtgctg gaatgcagag gatgtggtgg catttgtttc ccacagaggc    480

ccactgttca tttggaccat ctcaggacca gatagtggag tgattgtaca caaagatgct    540

catagcttct tgtctgatat ctgtatgttc agatggcata cacaccaaaa ggggaaagtt    600

gtgtttggtc atattgatgg aagtctatca atttttcatc caggtaataa aaatcagaaa    660

catgttttga gaccagaatc tcttgaaggg acagatgaag aggatccagt tacggccttg    720

gaatgggacc cactatctac tgattatctt ctagtggtta atttgcatta tggaattcgc    780

ctggtagatt ctgaatcact ttcttgcata acaacattta atcttcccag tgcagcagct    840

tctgtacagt gcttagcctg ggttcccagt gctcctggga tgtttataac tggagattct    900

caagtgggtg ttttacgcat ttggaatgtt tcaagaacaa cacctattga taatcttaaa    960

ttaaagaaaa caggatttca ctgcttacat gtacttaatt ctcctccaag aaaaaagttt   1020

tcagtccaat ctccaaccaa aaatcattat acatcctcaa caagcgaagc agttccaccc   1080

ccaactttaa cacagaatca agcattttct cttcctcctg gtcatgcagt gtgttgtttc   1140

ttggatggtg gagttggact ttatgatatg ggagctaaga agtgggattt tcttagagac   1200

ttgggacatg tggaaactat ctttgactgc aaattcaaac ctgacgatcc taatctttta   1260

gcaacagctt catttgatgg cactataaaa gtctgggata taaacacatt aacagcagtg   1320

tacacatccc cgggtaatga aggtgttatt tattcccttt cttgggctcc aggtggttta   1380

aattgtattg ctgggggaac ttcccgaaat ggtgctttta tttggaatgt tcaaaagggc   1440

aaaattatac aacgatttaa tgagcatgga acaaatggaa tattctgcat tgcctggagt   1500

cataaagatt ctaaaagaat agcaacctgc agcagtgatg gtttctgtat tattcgaaca   1560

attgatggta aagtgctaca caaatataaa catccagctg cagtgtttgg ttgtgattgg   1620

agccaaaaca ataaagacat gatagccact ggctgtgaag acacaaatgt tcgtgtttat   1680

tatgtagcca ccagctcaga tcaaccattg aaagtattta gtgggcatac agcaaaagtg   1740

tttcatgtta aatggtctcc tctgagagag ggaattcttt gcagtggttc tgatgatggt   1800

accgttcgaa tctgggatta tactcaggat gcttgcatca atattcttaa tggacacact   1860

gcacctgtga gaggattaat gtggaatact gagattccat atctgctcat atctggcagc   1920

tgggactata ctataaaagt atgggacact cgagaaggaa cttgtgtgga tactgtgtat   1980

gatcacggtg cagatgtata tggtttaacc tgccatccca gtcgcccctt cactatggcc   2040

tcttgctccc gtgactctac agtgagactc tggtcattaa cagccttagt cactcctgta   2100

caaataaata ttctggcaga cagatcttgg gaagaaatta ttgggaacac tgattatgct   2160

atagaaccag gcactcctcc tctactgtgt ggtaaagtgt caagagatat tagacaggaa   2220

atagaaaaac taactgctaa ttctcaagtg aaaaaactaa gatggttctc agaatgttta   2280

tctcctccag gtggcagtga caatttatgg aacttggttg ctgtgataaa aggacaggat   2340

gatagcttac ttcctcagaa ctactgcaaa ggaataatgc acttgaaaca tctgattaaa   2400

tttagaacat ctgaagctca agaactaaca acagtcaaga tgtctaaatt tggtggtggt   2460

attggtgtac ctgctaaaga ggaaagactg aaggaagctg ctgaaatcca cttgagatta   2520

ggacaaattc agagatactg tgaacttatg gttgaacttg gagagtggga caaagccctg   2580

tcaattgcac caggagtctc tgtgaaatac tggaagaagt taatgcagag gagagctgac   2640

caattaatcc aggaagataa ggatgatgtc attccatact gcatagccat tggtgatgtg   2700

aaaaagctag tccatttttt catgtcaaga ggtcagctta aagaagctct gcttgttgca   2760

caggctgctt gtgaaggaaa tatgcagccc ttacatgttt ccgtgcctaa aggagcttca   2820

tattctgatg atatctacaa ggaagacttt aatgaactcc tgcacaaagt cagtaaagaa   2880

ctggcagaat ggtattttca agatggtcga gcagtactag ccgcatgttg ccatcttgcc   2940

atagataata ttgagcttgc tatggcatac ctgattcgcg gaaatgaact ggagttggca   3000

gtctgtgtgg gcacagtact aggagagtct gcagcaccag caacccacta tgccttagaa   3060

ttactggcga gaaagtgcat gatgatttca gtatgctttc catgtgttgg atacagtgtc   3120

cccttttgtt acgttaacag gaatttggca gctgatcttc ttctgatgat tcctgataat   3180

gaactacatt taataaaact ctgtgctttc tacccaggat gtactgaaga gataaatgac   3240

cttcatgata agtgtaagct acccacagtg gaagaatgta tgcagttagc tgagacagcc   3300

cgtgcagatg acaatatatt tgaaactgta aaatattact tgttaagtca agaacctgaa   3360

aaagcccttc ctattggtat tagctttgtt aaagaataca tcagtagctc agactggact   3420

ttggatacca tataccctgt tcttgaccta ctgagctata ttcgtactga aaaattactc   3480

ttgcatacgt gtactgaagc tcgaaatgag ttgctgatat tatgtggtta cattggtgca   3540

ttactggcta tcagaagaca gtaccaaagc attgttccag cactttatga gtacacaagt   3600

cagctattaa aacgtcggga ggtgtcagta cctttaaaaa ttgaatatct ttctgaggaa   3660

ttggatgcat ggagagcttg cacacagtcc accaacagat cattagaaga ctctccgtat   3720

acaccccctt ctgattcaca aagaatgatt tatgcaactt tattaaagag actaaaagaa   3780

gagtcactga aaggaattat tggaccagat tatgtgactg gatcaaatct tccaagtcat   3840

tctgatattc acatttcttg tcttacggga ttaaaaatcc agggccctgt gtttttcctt   3900

gaagacggga aatctgctat ctccttgaat gatgctttga tgtgggcaaa ggtgaatcca   3960

ttctcacctt tagggactgg aatacgactc aatccattct gatagaagat ttttgtccat   4020

gcttgatttt tttttttaaa gaaaaacttt catgggttag cattacctta atctttgttg   4080

ctcaagtgcc agaggttggg agaaggattg caggttggga gaggtgggaa atagcagtga   4140

attttagtca ttaacttcaa aatatatata tatatataat ttaaaggaaa aataggtgcc   4200

tcctttataa acagtaatag ctacgtttgg gaaggaggaa acatttaaat tataaaggac   4260

tgaataatct aaaaagcata taaaagtttc acacagcata aaagatacca aaatatcata   4320

tggttgaaat attgaaacat attaaattgt gcaacaccta gaatagtgct agacatacag   4380

taagtactta atggatattt gaatgattga atatcttgaa atgttgaaat gtaaggtgtg   4440

cacagtgatc ttcaacttaa caaacactta cgttctcctt tataaaatgc atagtaaacc   4500

actaacgtta gctgttttaa taaaagtttt cagttataag tttagtaaat attaataaat   4560

ggatacacat tcaaaatact tttaaaaaaa agaaaatgtt accagttttt ttatctgaag   4620

tttaactgtc ccattgtaaa ggtgtaagtt atataggctt gaaaaaaatt ggcgggtaaa   4680

aatcacaaaa tgcagtcgaa tatatatatg aaaacttgca ttaggtgata aagtgactat   4740

tttaagagat tcagcatgca tggatattag ttttgattaa tgtgtacaat aatttacaca   4800

gtatactcta gtcaatttat gttaacttta tttaaaacac aatttatttg gccgggcacg   4860

gtggctcaca cctgtaatct cagcactttg gcaggccaag gcaggtggat cacctgaggt   4920

caggagttca tgaccagcct ggccagcatg gtaaaaccct gtctccacta aaaatacaaa   4980

aattagccag gcatggtggc gggcacctgt aatcccagtt acttgggaag ctgaggcagg   5040

agaatccctt gaacctggga ggcagaggtt ccagtgagcc aagatcgcac cactgcactc   5100

cagcctgggc aacaaagagc gaaactctgt ctcaaaaaac aaaccaacaa aaaccacaat   5160

tgatttgatg aaaattagtt ttaagtaaat gtttgtaaat agatattggt tgaatttttg   5220

gatatattat gttgatttaa cttttaaaat gttgtttaaa agtgtgaagc tatgaaaagc   5280

ctgataatgt gactacagat atttcagttg gactagaatt ctgactttga aacttattaa   5340

attaatgcat actggaagta ctttgatact caagttgttt cacaagattt ataatataga   5400

tggttttgtt tgactaaaga ataatctcat ataactagaa tacttgtggc ttttattatc   5460

tttaaacttg ttgcatttaa aatattttta aaaccttctt aacaaaactt cttaaaactg   5520

gaaaaaatat atattatgta tctatgtatc atatttatca catgaccact tttgattcct   5580

taaaaagaca ttacaggctt aaattccatt ttattaaaaa aaaaaaattg cctgtaatcc   5640

cagcacttca ggaggccgag atgggcagat cttgaggtcg gtagatggag accatcctgg   5700

ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa ttagctgggt gtggtggtgt   5760

gtacctgtag tcccagctac ccaggaagct aaggcaggag aatcgcttga atccaggagg   5820

cggaggttgc agtgagctga gatcgcacta ctgcactcca gcctgggcga cagagcaaga   5880

ccaccatctc caaaaattat atatataaaa ataattaata ttatagaaga gaatatacac   5940

aactcagaga tgcaatggat aatataaaaa gagtacctga gatgtatttt tttaaactct   6000

tagagatatc tgtaactcaa atttttctta ggtgaggagg attattaact ggcacatatg   6060

tactaaaaac ccctcactta aaaatggcag tctcaatcct actgtcattc tttttatttt   6120

aaaataaata aataagccta tctttttgtg cttacatact taaaaggata tcattaagta   6180

tataaacaat cattacttct gtatttttaa tgaatgcagg aaaataatat ttttatgtat   6240

aaaagatgaa gaaaaaattt tgcaagtctt taagcacata aatacaacag aatagccacc   6300

caatttctgt ctgaaatcta aattggatgg atttgaccat cattctatta tctttgattt   6360

ctacaatgtc tatatcttat tacctataac tattaatttt tcatagaatt ataaatgtca   6420

tttgactatg tcaatctgta tatattgtac cttaatatga aaaacaaatt ttttaattca   6480

taaaagtatt tttattagat ttcatatgca tgaaacccaa gcaaattata tgaatttatt   6540

ttactatttg aaaatgttca tattaccaat aatgtggaca aattactttg caggtttaaa   6600

tatgcctctg taaaggaaga gtctcattag acaatgattt ttaaagcatt ggaaaaatat   6660

tttgcctgta aaagttagta actaggtggt tcacaaaatt acaacatcaa aatagttaca   6720

tcttgtgaaa atatatgatt tttatgtcaa tcaagacaaa tgaaatatat atgtatgtgt   6780

atatatatac atgtatgtat gaaatatata tatgtgcgtg tgtgtgtgta tatatatata   6840

tatatatata tatttctatg aaattgtcca gatgtgttca ggaacatgat tgcattagag   6900

caatgactgt attttgttgt ccttataaca tttatattat ttcagtttta agtcaaaagg   6960

tattctgaat ataataaaag cctcacaaat tatttgtaaa atttagtagt tcatatttag   7020

tatatcagta atatagaaga catctttata gtcaactctt aattaatgct tattgtacca   7080

aatctttgag atatttgtac ataaatgaaa tatgtacttt catgctaaaa ttatatatca   7140

tgactgtgct ataatttggc atgtcattat ctagatttat atgtatgtac gtatttcagg   7200

tccttgaaat tttaataaat attacagtta aatcctgaaa aaaaaaaaaa aaaaa        7255


<210>  960
<211>  1298
<212>  PRT
<213>  Homosapiens

<400>  960

Met Ser Gln Val Arg Gln Val Gly Leu Leu Ala Ala Gly Cys Gln Pro 
1               5                   10                  15      


Trp Asn Lys Asp Val Cys Ala Ala Ser Gly Asp Arg Phe Ala Tyr Cys 
            20                  25                  30          


Ala Thr Leu Ala Ile Tyr Ile Tyr Gln Leu Asp His Arg Tyr Asn Glu 
        35                  40                  45              


Phe Lys Leu His Ala Ile Met Ser Glu His Lys Lys Thr Ile Thr Ala 
    50                  55                  60                  


Ile Ser Trp Cys Pro His Asn Pro Asp Leu Phe Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Asp Asn Leu Val Ile Ile Trp Asn Val Ala Glu Gln Lys Val Ile Ala 
                85                  90                  95      


Lys Leu Asp Ser Thr Lys Gly Ile Pro Ala Ser Leu Ser Trp Cys Trp 
            100                 105                 110         


Asn Ala Glu Asp Val Val Ala Phe Val Ser His Arg Gly Pro Leu Phe 
        115                 120                 125             


Ile Trp Thr Ile Ser Gly Pro Asp Ser Gly Val Ile Val His Lys Asp 
    130                 135                 140                 


Ala His Ser Phe Leu Ser Asp Ile Cys Met Phe Arg Trp His Thr His 
145                 150                 155                 160 


Gln Lys Gly Lys Val Val Phe Gly His Ile Asp Gly Ser Leu Ser Ile 
                165                 170                 175     


Phe His Pro Gly Asn Lys Asn Gln Lys His Val Leu Arg Pro Glu Ser 
            180                 185                 190         


Leu Glu Gly Thr Asp Glu Glu Asp Pro Val Thr Ala Leu Glu Trp Asp 
        195                 200                 205             


Pro Leu Ser Thr Asp Tyr Leu Leu Val Val Asn Leu His Tyr Gly Ile 
    210                 215                 220                 


Arg Leu Val Asp Ser Glu Ser Leu Ser Cys Ile Thr Thr Phe Asn Leu 
225                 230                 235                 240 


Pro Ser Ala Ala Ala Ser Val Gln Cys Leu Ala Trp Val Pro Ser Ala 
                245                 250                 255     


Pro Gly Met Phe Ile Thr Gly Asp Ser Gln Val Gly Val Leu Arg Ile 
            260                 265                 270         


Trp Asn Val Ser Arg Thr Thr Pro Ile Asp Asn Leu Lys Leu Lys Lys 
        275                 280                 285             


Thr Gly Phe His Cys Leu His Val Leu Asn Ser Pro Pro Arg Lys Lys 
    290                 295                 300                 


Phe Ser Val Gln Ser Pro Thr Lys Asn His Tyr Thr Ser Ser Thr Ser 
305                 310                 315                 320 


Glu Ala Val Pro Pro Pro Thr Leu Thr Gln Asn Gln Ala Phe Ser Leu 
                325                 330                 335     


Pro Pro Gly His Ala Val Cys Cys Phe Leu Asp Gly Gly Val Gly Leu 
            340                 345                 350         


Tyr Asp Met Gly Ala Lys Lys Trp Asp Phe Leu Arg Asp Leu Gly His 
        355                 360                 365             


Val Glu Thr Ile Phe Asp Cys Lys Phe Lys Pro Asp Asp Pro Asn Leu 
    370                 375                 380                 


Leu Ala Thr Ala Ser Phe Asp Gly Thr Ile Lys Val Trp Asp Ile Asn 
385                 390                 395                 400 


Thr Leu Thr Ala Val Tyr Thr Ser Pro Gly Asn Glu Gly Val Ile Tyr 
                405                 410                 415     


Ser Leu Ser Trp Ala Pro Gly Gly Leu Asn Cys Ile Ala Gly Gly Thr 
            420                 425                 430         


Ser Arg Asn Gly Ala Phe Ile Trp Asn Val Gln Lys Gly Lys Ile Ile 
        435                 440                 445             


Gln Arg Phe Asn Glu His Gly Thr Asn Gly Ile Phe Cys Ile Ala Trp 
    450                 455                 460                 


Ser His Lys Asp Ser Lys Arg Ile Ala Thr Cys Ser Ser Asp Gly Phe 
465                 470                 475                 480 


Cys Ile Ile Arg Thr Ile Asp Gly Lys Val Leu His Lys Tyr Lys His 
                485                 490                 495     


Pro Ala Ala Val Phe Gly Cys Asp Trp Ser Gln Asn Asn Lys Asp Met 
            500                 505                 510         


Ile Ala Thr Gly Cys Glu Asp Thr Asn Val Arg Val Tyr Tyr Val Ala 
        515                 520                 525             


Thr Ser Ser Asp Gln Pro Leu Lys Val Phe Ser Gly His Thr Ala Lys 
    530                 535                 540                 


Val Phe His Val Lys Trp Ser Pro Leu Arg Glu Gly Ile Leu Cys Ser 
545                 550                 555                 560 


Gly Ser Asp Asp Gly Thr Val Arg Ile Trp Asp Tyr Thr Gln Asp Ala 
                565                 570                 575     


Cys Ile Asn Ile Leu Asn Gly His Thr Ala Pro Val Arg Gly Leu Met 
            580                 585                 590         


Trp Asn Thr Glu Ile Pro Tyr Leu Leu Ile Ser Gly Ser Trp Asp Tyr 
        595                 600                 605             


Thr Ile Lys Val Trp Asp Thr Arg Glu Gly Thr Cys Val Asp Thr Val 
    610                 615                 620                 


Tyr Asp His Gly Ala Asp Val Tyr Gly Leu Thr Cys His Pro Ser Arg 
625                 630                 635                 640 


Pro Phe Thr Met Ala Ser Cys Ser Arg Asp Ser Thr Val Arg Leu Trp 
                645                 650                 655     


Ser Leu Thr Ala Leu Val Thr Pro Val Gln Ile Asn Ile Leu Ala Asp 
            660                 665                 670         


Arg Ser Trp Glu Glu Ile Ile Gly Asn Thr Asp Tyr Ala Ile Glu Pro 
        675                 680                 685             


Gly Thr Pro Pro Leu Leu Cys Gly Lys Val Ser Arg Asp Ile Arg Gln 
    690                 695                 700                 


Glu Ile Glu Lys Leu Thr Ala Asn Ser Gln Val Lys Lys Leu Arg Trp 
705                 710                 715                 720 


Phe Ser Glu Cys Leu Ser Pro Pro Gly Gly Ser Asp Asn Leu Trp Asn 
                725                 730                 735     


Leu Val Ala Val Ile Lys Gly Gln Asp Asp Ser Leu Leu Pro Gln Asn 
            740                 745                 750         


Tyr Cys Lys Gly Ile Met His Leu Lys His Leu Ile Lys Phe Arg Thr 
        755                 760                 765             


Ser Glu Ala Gln Glu Leu Thr Thr Val Lys Met Ser Lys Phe Gly Gly 
    770                 775                 780                 


Gly Ile Gly Val Pro Ala Lys Glu Glu Arg Leu Lys Glu Ala Ala Glu 
785                 790                 795                 800 


Ile His Leu Arg Leu Gly Gln Ile Gln Arg Tyr Cys Glu Leu Met Val 
                805                 810                 815     


Glu Leu Gly Glu Trp Asp Lys Ala Leu Ser Ile Ala Pro Gly Val Ser 
            820                 825                 830         


Val Lys Tyr Trp Lys Lys Leu Met Gln Arg Arg Ala Asp Gln Leu Ile 
        835                 840                 845             


Gln Glu Asp Lys Asp Asp Val Ile Pro Tyr Cys Ile Ala Ile Gly Asp 
    850                 855                 860                 


Val Lys Lys Leu Val His Phe Phe Met Ser Arg Gly Gln Leu Lys Glu 
865                 870                 875                 880 


Ala Leu Leu Val Ala Gln Ala Ala Cys Glu Gly Asn Met Gln Pro Leu 
                885                 890                 895     


His Val Ser Val Pro Lys Gly Ala Ser Tyr Ser Asp Asp Ile Tyr Lys 
            900                 905                 910         


Glu Asp Phe Asn Glu Leu Leu His Lys Val Ser Lys Glu Leu Ala Glu 
        915                 920                 925             


Trp Tyr Phe Gln Asp Gly Arg Ala Val Leu Ala Ala Cys Cys His Leu 
    930                 935                 940                 


Ala Ile Asp Asn Ile Glu Leu Ala Met Ala Tyr Leu Ile Arg Gly Asn 
945                 950                 955                 960 


Glu Leu Glu Leu Ala Val Cys Val Gly Thr Val Leu Gly Glu Ser Ala 
                965                 970                 975     


Ala Pro Ala Thr His Tyr Ala Leu Glu Leu Leu Ala Arg Lys Cys Met 
            980                 985                 990         


Met Ile Ser Val Cys Phe Pro Cys  Val Gly Tyr Ser Val  Pro Phe Cys 
        995                 1000                 1005             


Tyr Val  Asn Arg Asn Leu Ala  Ala Asp Leu Leu Leu  Met Ile Pro 
    1010                 1015                 1020             


Asp Asn  Glu Leu His Leu Ile  Lys Leu Cys Ala Phe  Tyr Pro Gly 
    1025                 1030                 1035             


Cys Thr  Glu Glu Ile Asn Asp  Leu His Asp Lys Cys  Lys Leu Pro 
    1040                 1045                 1050             


Thr Val  Glu Glu Cys Met Gln  Leu Ala Glu Thr Ala  Arg Ala Asp 
    1055                 1060                 1065             


Asp Asn  Ile Phe Glu Thr Val  Lys Tyr Tyr Leu Leu  Ser Gln Glu 
    1070                 1075                 1080             


Pro Glu  Lys Ala Leu Pro Ile  Gly Ile Ser Phe Val  Lys Glu Tyr 
    1085                 1090                 1095             


Ile Ser  Ser Ser Asp Trp Thr  Leu Asp Thr Ile Tyr  Pro Val Leu 
    1100                 1105                 1110             


Asp Leu  Leu Ser Tyr Ile Arg  Thr Glu Lys Leu Leu  Leu His Thr 
    1115                 1120                 1125             


Cys Thr  Glu Ala Arg Asn Glu  Leu Leu Ile Leu Cys  Gly Tyr Ile 
    1130                 1135                 1140             


Gly Ala  Leu Leu Ala Ile Arg  Arg Gln Tyr Gln Ser  Ile Val Pro 
    1145                 1150                 1155             


Ala Leu  Tyr Glu Tyr Thr Ser  Gln Leu Leu Lys Arg  Arg Glu Val 
    1160                 1165                 1170             


Ser Val  Pro Leu Lys Ile Glu  Tyr Leu Ser Glu Glu  Leu Asp Ala 
    1175                 1180                 1185             


Trp Arg  Ala Cys Thr Gln Ser  Thr Asn Arg Ser Leu  Glu Asp Ser 
    1190                 1195                 1200             


Pro Tyr  Thr Pro Pro Ser Asp  Ser Gln Arg Met Ile  Tyr Ala Thr 
    1205                 1210                 1215             


Leu Leu  Lys Arg Leu Lys Glu  Glu Ser Leu Lys Gly  Ile Ile Gly 
    1220                 1225                 1230             


Pro Asp  Tyr Val Thr Gly Ser  Asn Leu Pro Ser His  Ser Asp Ile 
    1235                 1240                 1245             


His Ile  Ser Cys Leu Thr Gly  Leu Lys Ile Gln Gly  Pro Val Phe 
    1250                 1255                 1260             


Phe Leu  Glu Asp Gly Lys Ser  Ala Ile Ser Leu Asn  Asp Ala Leu 
    1265                 1270                 1275             


Met Trp  Ala Lys Val Asn Pro  Phe Ser Pro Leu Gly  Thr Gly Ile 
    1280                 1285                 1290             


Arg Leu  Asn Pro Phe 
    1295             


<210>  961
<211>  1233
<212>  DNA
<213>  Homosapiens

<400>  961
gcgctgaggt ctcgccccat aagactccgc cccgccccac gaggccgcgc cgccagcaat     60

aaggcccagc cccgccttct gctgttgccg cagcaaccca gaaagcgtca tggctgccgc    120

cggccaggaa aaagggtatt tgacacagac tgcggcagcc ctagacaagt caccgtcact    180

ttcgccacag ctagcagctc ccatccgagg gaggcctaag aagtgtctgg tctatccgca    240

tgcgccgaag agctcccgct tgtctcgttc cgttctgcgt tggcttcagg gtctggatct    300

cagcttcttc cccaggaaca tcaacagaga tttttcaaat ggcttcctaa ttgcagaaat    360

attctgtata tattacccct gggaacttga attatcatcc tttgaaaacg ggacctcttt    420

aaaagtcaag ttggataact gggcacagtt ggagaagttc ctggcaagaa aaaaatttaa    480

attacctaaa gaactaatcc atggaacaat tcattgtaaa gctggagtgc ctgaaatatt    540

gatagaagag gtttacactt tattaacaca tcgagaaatt aaaagtatcc aggatgactt    600

tgtgaatttc acggactata gctaccagat gcgtttaccc ctggtttcca ggtctacagt    660

ttcgaagtct attaaagata acattaggtt atcagaatta ctaagcaatc ccaacatgct    720

gaccaatgaa cttaaagcgg agttcctcat ccttttacat atgttgcaaa gaaaattagg    780

cagaaaattg aatccagaat ggtttgatgt gaaaccaaca gtgggagaag ttactctcaa    840

tcaccttcct gcccaagcct ctgggcgcag atataattta aaagttaaaa gaggaagagt    900

tgtccctgtt ttaccaaata taggtagtgg tggcagttca catagagaaa tacatgtgaa    960

gcaagctgga caacattctt attactctgc tatgaaacct atcagaaaca tggacaagaa   1020

accttgaaaa gcacctgtca aatggctttg aagaagtgat gccaccatct ctagccataa   1080

taaagaaaca gaatcaccta gtattggatg tatttcaata ataaatagag tggtgtcttt   1140

tccataattg tgttaaagaa catttctttt ccattcaatt tgtttattaa actcctatgc   1200

caggcattgt tgaaaataca aaattaaata aat                                1233


<210>  962
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  962

Met Ala Ala Ala Gly Gln Glu Lys Gly Tyr Leu Thr Gln Thr Ala Ala 
1               5                   10                  15      


Ala Leu Asp Lys Ser Pro Ser Leu Ser Pro Gln Leu Ala Ala Pro Ile 
            20                  25                  30          


Arg Gly Arg Pro Lys Lys Cys Leu Val Tyr Pro His Ala Pro Lys Ser 
        35                  40                  45              


Ser Arg Leu Ser Arg Ser Val Leu Arg Trp Leu Gln Gly Leu Asp Leu 
    50                  55                  60                  


Ser Phe Phe Pro Arg Asn Ile Asn Arg Asp Phe Ser Asn Gly Phe Leu 
65                  70                  75                  80  


Ile Ala Glu Ile Phe Cys Ile Tyr Tyr Pro Trp Glu Leu Glu Leu Ser 
                85                  90                  95      


Ser Phe Glu Asn Gly Thr Ser Leu Lys Val Lys Leu Asp Asn Trp Ala 
            100                 105                 110         


Gln Leu Glu Lys Phe Leu Ala Arg Lys Lys Phe Lys Leu Pro Lys Glu 
        115                 120                 125             


Leu Ile His Gly Thr Ile His Cys Lys Ala Gly Val Pro Glu Ile Leu 
    130                 135                 140                 


Ile Glu Glu Val Tyr Thr Leu Leu Thr His Arg Glu Ile Lys Ser Ile 
145                 150                 155                 160 


Gln Asp Asp Phe Val Asn Phe Thr Asp Tyr Ser Tyr Gln Met Arg Leu 
                165                 170                 175     


Pro Leu Val Ser Arg Ser Thr Val Ser Lys Ser Ile Lys Asp Asn Ile 
            180                 185                 190         


Arg Leu Ser Glu Leu Leu Ser Asn Pro Asn Met Leu Thr Asn Glu Leu 
        195                 200                 205             


Lys Ala Glu Phe Leu Ile Leu Leu His Met Leu Gln Arg Lys Leu Gly 
    210                 215                 220                 


Arg Lys Leu Asn Pro Glu Trp Phe Asp Val Lys Pro Thr Val Gly Glu 
225                 230                 235                 240 


Val Thr Leu Asn His Leu Pro Ala Gln Ala Ser Gly Arg Arg Tyr Asn 
                245                 250                 255     


Leu Lys Val Lys Arg Gly Arg Val Val Pro Val Leu Pro Asn Ile Gly 
            260                 265                 270         


Ser Gly Gly Ser Ser His Arg Glu Ile His Val Lys Gln Ala Gly Gln 
        275                 280                 285             


His Ser Tyr Tyr Ser Ala Met Lys Pro Ile Arg Asn Met Asp Lys Lys 
    290                 295                 300                 


Pro 
305 


<210>  963
<211>  2929
<212>  DNA
<213>  Homosapiens

<400>  963
agattcttct gcagcaatgt cggtgttaga agaaaatcgg ccgtttgctc aacaattatc     60

caatgtctac tttacaatac tttcgctgtt ctgttttaag ctttttgtga aaatcagcct    120

tgccatcctc agtcatttct acatagtgaa aggcaaccgc aaggaagcgg caaggatagc    180

agctgaattt tatggagtaa cccaaggaca aggttcctgg gcagatcgat caccactaca    240

tgaagcagca agtcaaggtc gccttcttgc tctgagaaca ttattatcac agggttataa    300

tgtaaatgca gtaaccttag accatgtcac cccattgcac gaagcctgcc ttggagatca    360

cgtggcatgt gccagaactc tgctggaagc aggagctaat gtaaatgcaa tcacgataga    420

tggcgtgact ccgttattca acgcatgctc ccaaggcagt ccaagctgtg cagagctgct    480

tctggagtat ggtgccaaag cccagctgga gtcatgtctt ccatccccaa cgcatgaggc    540

cgccagtaaa ggtcaccatg aatgtcttga catcctgata tcctggggca tagatgttga    600

ccaagaaatt cctcatttgg gaactcctct ctatgtagct tgtatgtcac agcaattcca    660

ttgcatctgg aagcttcttt atgctggtgc tgacgtacag aaaggcaaat attgggatac    720

tccattacat gctgctgctc aacaatccag cacagaaatt gtaaacttac tgctagaatt    780

tggagcagat atcaatgcca aaaatacaga gcttctgcga cctatagatg tagctacgtc    840

tagcagtatg gtggaaagga tattgcttca acatgaagct accccaagct ctctttacca    900

actttgccga ctctgtatcc gaagctacat aggaaaacca agattgcacc ttatcccaca    960

actccagctg ccaacgttac tgaagaattt cttacagtat cgataaaaca gtaaagtaat   1020

tctaaatacc ttgaaaatca aaatttctat ttcttttgct taaggaatag ttcatataaa   1080

aatatgctaa agataggata aaagtgagtg tgagatcacc cagggaagca gtaaaatatc   1140

aattttcatt ttaagtgtat tagtactatt gttttatcat ttatgctgtc tttggattat   1200

agcatattta taatatctat tttttgttat ttcaatatac cctcttgttt attcaggaaa   1260

aaataataaa gtcactatct tatgttttct tttggattgg aaagaaataa agctcctagt   1320

aaagttattc atattatatt taaaaaggtc tatgttcttc aactaatggg ttaacttttt   1380

aattttggct attgtaattg gctaacttgt tactgatatt gacataaaat atgaatatgg   1440

cttagcaaag agcaactaat atgttttctg aaaccaggat gatgctcatt caggaaatcc   1500

actatgttga atgtccactg gtcattagaa tgaacacttc ataaagataa attgcccccc   1560

tctcccccac ttacccctgg caaaggactc acaagtcact tctcttctcc atagtacatg   1620

gacttgttac agaaaagtga taggatgaaa ggtcaatact gccctctcac cctgagatat   1680

ttagaacatt acacaccttc taaggctatg ttaagactgc ctccttctca ggagtagccc   1740

ctgatgatct cttatcaagg cggttatatg catattactc cagccttctt ccatttcaga   1800

aattgtcaat agctagtgat acttggactt aagaaaatga actatatatc taattaacaa   1860

acaggccctg gatcatattc cggggatcat cacatcagtc caaggatata aaaaaatgga   1920

agattaaaaa ctcaaattgt ggagttttta aagagtgggt gccacttaac acattggaga   1980

ccttaaaaaa tgtatataga gaacttaatc gcactgtttc taattctttt tacacaaaac   2040

aagggcttag agtatactgt atttgcaagt aatagcaaga gagtattgta taaaagaaga   2100

tattactaag ctagtcctct gcaagggtaa atactatgtt tattctcttc agctttaact   2160

atacttgagt gcaataaaaa acttaataaa attttatgcc tgttttgtaa ttcagggcct   2220

attatgattt tagaaataag ataatcaacg tacaactctt tgtaaaacaa aagcaacttt   2280

gggtgagttt tatagattta ttaaattttg ataaagtaaa tattttgacc actattttca   2340

acaacccagg gcttattttc ttctgacttc ttggctaact tccagactat gggaaaataa   2400

attatgattg tatgtgaccc ccagatcact aagcttgcat tttggcagaa agaaaaaaaa   2460

tcagttgtga tttaaaacgt ttgttgagat tttcaaacat agaaataaag ctgtagcata   2520

ttcactaaac aatgttttat atgaggatag ggacctttaa atatgtgttt tatagaatat   2580

ctcacacatt tgtaatggat aacgtgcatt aaaatggagt tcttattata gaataacctg   2640

gttaaacaga tattaaagct gcttttgggt aaaacaggtt tccaccagta ttttccctga   2700

gctagaggag aagtcttaga ttttaagagt aatacaaccc atctatctta ttagtcttgt   2760

gccaataaga gaagtaaata tcaaacatta aaatggtcac tttacaattt cagtatgtct   2820

gtaccttgta tcttagcttg agtatgattg tcttatcaaa gtagtgttct aactttaatg   2880

tattgtatgt ttgttattat attaaagtgt gattattatt cattggaat               2929


<210>  964
<211>  329
<212>  PRT
<213>  Homosapiens

<400>  964

Met Ser Val Leu Glu Glu Asn Arg Pro Phe Ala Gln Gln Leu Ser Asn 
1               5                   10                  15      


Val Tyr Phe Thr Ile Leu Ser Leu Phe Cys Phe Lys Leu Phe Val Lys 
            20                  25                  30          


Ile Ser Leu Ala Ile Leu Ser His Phe Tyr Ile Val Lys Gly Asn Arg 
        35                  40                  45              


Lys Glu Ala Ala Arg Ile Ala Ala Glu Phe Tyr Gly Val Thr Gln Gly 
    50                  55                  60                  


Gln Gly Ser Trp Ala Asp Arg Ser Pro Leu His Glu Ala Ala Ser Gln 
65                  70                  75                  80  


Gly Arg Leu Leu Ala Leu Arg Thr Leu Leu Ser Gln Gly Tyr Asn Val 
                85                  90                  95      


Asn Ala Val Thr Leu Asp His Val Thr Pro Leu His Glu Ala Cys Leu 
            100                 105                 110         


Gly Asp His Val Ala Cys Ala Arg Thr Leu Leu Glu Ala Gly Ala Asn 
        115                 120                 125             


Val Asn Ala Ile Thr Ile Asp Gly Val Thr Pro Leu Phe Asn Ala Cys 
    130                 135                 140                 


Ser Gln Gly Ser Pro Ser Cys Ala Glu Leu Leu Leu Glu Tyr Gly Ala 
145                 150                 155                 160 


Lys Ala Gln Leu Glu Ser Cys Leu Pro Ser Pro Thr His Glu Ala Ala 
                165                 170                 175     


Ser Lys Gly His His Glu Cys Leu Asp Ile Leu Ile Ser Trp Gly Ile 
            180                 185                 190         


Asp Val Asp Gln Glu Ile Pro His Leu Gly Thr Pro Leu Tyr Val Ala 
        195                 200                 205             


Cys Met Ser Gln Gln Phe His Cys Ile Trp Lys Leu Leu Tyr Ala Gly 
    210                 215                 220                 


Ala Asp Val Gln Lys Gly Lys Tyr Trp Asp Thr Pro Leu His Ala Ala 
225                 230                 235                 240 


Ala Gln Gln Ser Ser Thr Glu Ile Val Asn Leu Leu Leu Glu Phe Gly 
                245                 250                 255     


Ala Asp Ile Asn Ala Lys Asn Thr Glu Leu Leu Arg Pro Ile Asp Val 
            260                 265                 270         


Ala Thr Ser Ser Ser Met Val Glu Arg Ile Leu Leu Gln His Glu Ala 
        275                 280                 285             


Thr Pro Ser Ser Leu Tyr Gln Leu Cys Arg Leu Cys Ile Arg Ser Tyr 
    290                 295                 300                 


Ile Gly Lys Pro Arg Leu His Leu Ile Pro Gln Leu Gln Leu Pro Thr 
305                 310                 315                 320 


Leu Leu Lys Asn Phe Leu Gln Tyr Arg 
                325                 


<210>  965
<211>  1544
<212>  DNA
<213>  Homosapiens

<400>  965
gcgctcccgg aacgcgcgca ccgcagacgg cgcggatcgc agggagccgg tccgccgccg     60

gaacgggagc ctgggtgtgc gtgtggagtc cggactcgtg ggagacgatc gcgatgaaca    120

cggtgctgtc gcgggcgaac tcactgttcg ccttctcgct gagcgtgatg gcggcgctca    180

ccttcggctg cttcatcacc accgccttca aagacaggag cgtcccggtg cggctgcacg    240

tctcgcggat catgctaaaa aatgtagaag atttcactgg acctagagaa agaagtgatc    300

tgggatttat cacatttgat ataactgctg atctagagaa tatatttgat tggaatgtta    360

agcagttgtt tctttattta tcagcagaat attcaacaaa aaataatgct ctgaaccaag    420

ttgtcctatg ggacaagatt gttttgagag gtgataatcc gaagctgctg ctgaaagata    480

tgaaaacaaa atattttttc tttgacgatg gaaatggtct caagggaaac aggaatgtca    540

ctttgaccct gtcttggaac gtcgtaccaa atgctggaat tctacctctt gtgacaggat    600

caggacacgt atctgtccca tttccagata catatgaaat aacgaagagt tattaaatta    660

ttctgaattt gaaacaacat atttttatac ttaatgaatt gtatctcatt aatctcttcc    720

cttacatctt catgtattgt tggtttgttt tttggttttg ggtttttttt tttttttttt    780

ggtataagaa ctaacatcaa aaggcctgtt taaagggaaa ggttaatggg ctacttaata    840

ttatgaacaa aacaaaaaaa caaggctgcc acagtggaat attatcttac aagaataaga    900

actacataaa acagatttgt aaaaaataca tatttgaagt attccctgta tttccattat    960

tctttatgga atataaagta agcatgaaag gtagttaaaa ctttcaggtg cctgtagagt   1020

cataataact gtattttatg ccttgcattc acgcaaattc acattggatg tgatttaaaa   1080

gtagacattc tctttttcct cttttaggat atgtttgatt actggaaaat taatatggtt   1140

atttgttaga agtctggttt ataaaaaagc caaaagtgat ggaatttatt ccatttgtct   1200

taggaaggcc cataatactt gtttttctta catgtgacta gcaactttct ccacttaaag   1260

actaaatacc tctttatatg atgtaaatta ttctaattca ttttaaaatc ttttaggtca   1320

gcaaaatgtg tgtcttcagt gctttctcta aaaacgttcc tttatagctt tgtacttttt   1380

tttttagcgt tgccattgaa agttaaaatg tttgcatggt ttaccctctg agttatgttt   1440

cttctagtga gcatgcctgc tgtcactaag tgaattattt actacttttt gtaggtctat   1500

attttaataa ttattgggat aataataaaa aaaaaaaaaa aaaa                    1544


<210>  966
<211>  180
<212>  PRT
<213>  Homosapiens

<400>  966

Met Asn Thr Val Leu Ser Arg Ala Asn Ser Leu Phe Ala Phe Ser Leu 
1               5                   10                  15      


Ser Val Met Ala Ala Leu Thr Phe Gly Cys Phe Ile Thr Thr Ala Phe 
            20                  25                  30          


Lys Asp Arg Ser Val Pro Val Arg Leu His Val Ser Arg Ile Met Leu 
        35                  40                  45              


Lys Asn Val Glu Asp Phe Thr Gly Pro Arg Glu Arg Ser Asp Leu Gly 
    50                  55                  60                  


Phe Ile Thr Phe Asp Ile Thr Ala Asp Leu Glu Asn Ile Phe Asp Trp 
65                  70                  75                  80  


Asn Val Lys Gln Leu Phe Leu Tyr Leu Ser Ala Glu Tyr Ser Thr Lys 
                85                  90                  95      


Asn Asn Ala Leu Asn Gln Val Val Leu Trp Asp Lys Ile Val Leu Arg 
            100                 105                 110         


Gly Asp Asn Pro Lys Leu Leu Leu Lys Asp Met Lys Thr Lys Tyr Phe 
        115                 120                 125             


Phe Phe Asp Asp Gly Asn Gly Leu Lys Gly Asn Arg Asn Val Thr Leu 
    130                 135                 140                 


Thr Leu Ser Trp Asn Val Val Pro Asn Ala Gly Ile Leu Pro Leu Val 
145                 150                 155                 160 


Thr Gly Ser Gly His Val Ser Val Pro Phe Pro Asp Thr Tyr Glu Ile 
                165                 170                 175     


Thr Lys Ser Tyr 
            180 


<210>  967
<211>  984
<212>  DNA
<213>  Homosapiens

<400>  967
atgtcagaca agctcaagga acgcaaagtg agtcggctga gcccaaatgg cacttgcgcc     60

ctggtggtgg aggcatctga ctcaccgacc cgccacttgg gtggaccgat ggcagggaag    120

tgcccgcacg ggactttgag tgtggaggaa tctcgagtga gaacccccgt ttctcataaa    180

gtgatagaaa agcggaggag ggacaggatc aaccgctgct tgaacgagct gggcaagaca    240

gtgcccatgg ccttggcgaa gcagggcgaa cctcaggagg ctctggcgca gatccgcagc    300

cgcgtccgct cgctggtcct ctccagcgcc acagtgcccg accagcaggc gctgggccgc    360

tgcgaggggc ccttcctcct tttgcagagt tccgggaagc tggagaaggc ggagatcctc    420

gagatgaccg ttcagtacct gagagcactg cactccgctg attttccccg gggaagggaa    480

aaagcagaac ttctagcgga gtttgccaac tacttccact atggctacca cgagtgcatg    540

aagaacctgg tgcattacct caccacggtg gagcggatgg agaccaagga cacgaagtac    600

gcgcgcatcc tcgccttctt gcagtccaag gcccgcctgg gcgcggagcc cgcctttccg    660

ccgctgggtt cgctcccgga gccggatttc tcctatcagc tgcaccctgc ggggcccgaa    720

ttcgctggtc acagcccggg cgaggccgct gtgttcccgc agggctctgg tgccgggcct    780

ttcccctggc cgcctggcgc ggcccgcagc cccgcgctgc cctacctgcc cagcgcgcca    840

gtgccgctcg ctagcccagc gcagcagcac agccccttcc tgacaccggt gcagggcctg    900

gaccggcatt acctcaacct gatcggccac gcgcacccca acgcccttaa cctgcacacg    960

ccccagcacc ccccggtgct ctga                                           984


<210>  968
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  968

Met Ser Asp Lys Leu Lys Glu Arg Lys Val Ser Arg Leu Ser Pro Asn 
1               5                   10                  15      


Gly Thr Cys Ala Leu Val Val Glu Ala Ser Asp Ser Pro Thr Arg His 
            20                  25                  30          


Leu Gly Gly Pro Met Ala Gly Lys Cys Pro His Gly Thr Leu Ser Val 
        35                  40                  45              


Glu Glu Ser Arg Val Arg Thr Pro Val Ser His Lys Val Ile Glu Lys 
    50                  55                  60                  


Arg Arg Arg Asp Arg Ile Asn Arg Cys Leu Asn Glu Leu Gly Lys Thr 
65                  70                  75                  80  


Val Pro Met Ala Leu Ala Lys Gln Gly Glu Pro Gln Glu Ala Leu Ala 
                85                  90                  95      


Gln Ile Arg Ser Arg Val Arg Ser Leu Val Leu Ser Ser Ala Thr Val 
            100                 105                 110         


Pro Asp Gln Gln Ala Leu Gly Arg Cys Glu Gly Pro Phe Leu Leu Leu 
        115                 120                 125             


Gln Ser Ser Gly Lys Leu Glu Lys Ala Glu Ile Leu Glu Met Thr Val 
    130                 135                 140                 


Gln Tyr Leu Arg Ala Leu His Ser Ala Asp Phe Pro Arg Gly Arg Glu 
145                 150                 155                 160 


Lys Ala Glu Leu Leu Ala Glu Phe Ala Asn Tyr Phe His Tyr Gly Tyr 
                165                 170                 175     


His Glu Cys Met Lys Asn Leu Val His Tyr Leu Thr Thr Val Glu Arg 
            180                 185                 190         


Met Glu Thr Lys Asp Thr Lys Tyr Ala Arg Ile Leu Ala Phe Leu Gln 
        195                 200                 205             


Ser Lys Ala Arg Leu Gly Ala Glu Pro Ala Phe Pro Pro Leu Gly Ser 
    210                 215                 220                 


Leu Pro Glu Pro Asp Phe Ser Tyr Gln Leu His Pro Ala Gly Pro Glu 
225                 230                 235                 240 


Phe Ala Gly His Ser Pro Gly Glu Ala Ala Val Phe Pro Gln Gly Ser 
                245                 250                 255     


Gly Ala Gly Pro Phe Pro Trp Pro Pro Gly Ala Ala Arg Ser Pro Ala 
            260                 265                 270         


Leu Pro Tyr Leu Pro Ser Ala Pro Val Pro Leu Ala Ser Pro Ala Gln 
        275                 280                 285             


Gln His Ser Pro Phe Leu Thr Pro Val Gln Gly Leu Asp Arg His Tyr 
    290                 295                 300                 


Leu Asn Leu Ile Gly His Ala His Pro Asn Ala Leu Asn Leu His Thr 
305                 310                 315                 320 


Pro Gln His Pro Pro Val Leu 
                325         


<210>  969
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  969
ctgggcggcc gggcgcgggg agagggcgcg ggagcggctc gtgcggcagg taccatgcgg     60

acgcgcgagc ccggcgaggg ccccggcagg cccggtccct gctcgggggc gcgctgagac    120

ggcgggtgag ctccacgaga gcgccgtcgc cacttcgggc caactttgcg attcccgaca    180

gttaagcaat ggggagacat ttggctttgc tcctgcttct gctccttctc ttccaacatt    240

ttggagacag tgatggcagc caacgacttg aacagactcc tctgcagttt acacacctcg    300

agtacaacgt caccgtgcag gagaactctg cagctaagac ttatgtgggg catcctgtca    360

agatgggtgt ttacattaca catccagcgt gggaagtaag gtacaaaatt gtttccggag    420

acagtgaaaa cctgttcaaa gctgaagagt acattctcgg agacttttgc tttctaagaa    480

taaggaccaa aggaggaaat acagctattc ttaatagaga agtgaaggat cactacacat    540

tgatagtgaa agcacttgaa aaaaatacta atgtggaggc gcgaacaaag gtcagggtgc    600

aggtgctgga tacaaatgac ttgagaccgt tattctcacc cacctcatac agcgtttctt    660

tacctgaaaa cacagctata aggaccagta tcgcaagagt cagcgccacg gatgcagaca    720

taggaaccaa cggggaattt tactacagtt ttaaagatcg aacagatatg tttgctattc    780

acccaaccag tggtgtgata gtgttaactg gtagacttga ttacctagag accaagctct    840

atgagatgga aatcctcgct gcggaccgtg gcatgaagtt gtatgggagc agtggcatca    900

gcagcatggc caagctaacg gtgcacatcg aacaggccaa tgaatgtgct ccggtgataa    960

cagcagtgac attgtcacca tcagaactgg acagggaccc agcatatgca attgtgacag   1020

tggatgactg cgatcagggt gccaatggtg acatagcatc tttaagcatc gtggcaggtg   1080

accttctcca gcagtttaga acagtgaggt cctttccagg gagtaaggag tataaagtca   1140

aagccatcgg tggcattgat tgggacagtc atcctttcgg ctacaatctc acactacagg   1200

ctaaagataa aggaactccg ccccagttct cttctgttaa agtcattcac gtgacttctc   1260

cacagttcaa agccgggcca gtcaagtttg aaaaggatgt ttacagagca gaaataagtg   1320

aatttgctcc tcccaacaca cctgtggtca tggtaaaggc cattcctgct tattcccatt   1380

tgaggtatgt ttttaaaagt acacctggaa aagctaaatt cagtttaaat tacaacactg   1440

gtctcatttc tattttagaa ccagttaaaa gacagcaggc agcccatttt gaacttgaag   1500

taacaacaag tgacagaaaa gcgtccacca aggtcttggt gaaagtctta ggtgcaaata   1560

gcaatccccc tgaatttacc cagacagcgt acaaagctgc ttttgatgag aacgtgccca   1620

ttggtactac tgtcatgagc ctgagtgccg tagaccctga tgagggtgag aacgggtacg   1680

tgacatacag tatcgcaaat ttaaatcatg tgccgtttgc gattgaccat ttcactggtg   1740

ccgtgagtac gtcagaaaac ctggactacg aactgatgcc tcgggtttat actctgagga   1800

ttcgtgcatc agactggggc ttgccgtacc gccgggaagt cgaagtcctt gctacaatta   1860

ctctcaataa cttgaatgac aacacacctt tgtttgagaa aataaattgt gaagggacaa   1920

ttcccagaga tctaggcgtg ggagagcaaa taaccactgt ttctgctatt gatgcagatg   1980

aacttcagtt ggtacagtat cagattgaag ctggaaatga actggatttc tttagtttaa   2040

accccaactc gggggtattg tcattaaagc gatcgctaat ggatggctta ggtgcaaagg   2100

tgtctttcca cagtctgaga atcacagcta cagatggaga aaattttgcc acaccattat   2160

atatcaacat aacagtggct gccagtcaca agctggtaaa cttgcagtgt gaagagactg   2220

gtgttgccaa aatgctggca gagaagctcc tgcaggcaaa taaattacac aaccagggag   2280

aggtggagga tattttcttc gattctcact ctgtcaatgc tcacataccg cagtttagaa   2340

gcactcttcc gactggtatt caggtaaagg aaaaccagcc tgtgggttcc agtgtaattt   2400

tcatgaactc cactgacctt gacactggct tcaatggaaa actggtctat gctgtttctg   2460

gaggaaatga ggatagttgc ttcatgattg atatggaaac aggaatgctg aaaattttat   2520

ctcctcttga ccgtgaaaca acagacaaat acaccctgaa tattaccgtc tatgaccttg   2580

ggatacccca gaaggctgcg tggcgtcttc tacatgtcgt ggttgtcgat gccaatgata   2640

atccacccga gtttttacag gagagctatt ttgtggaagt gagtgaagac aaggaggtac   2700

atagtgaaat catccaggtt gaagccacag ataaagacct ggggcccaac ggacacgtga   2760

cgtactcaat tgttacagac acagacacat tttcaattga cagcgtgacg ggtgttgtta   2820

acatcgcacg ccctctggat cgagagctgc agcatgagca ctccttaaag attgaggcca   2880

gggaccaagc cagagaagag cctcagctgt tctccactgt cgttgtgaaa gtatcactag   2940

aagatgttaa tgacaaccca cctacattta ttccacctaa ttatcgtgtg aaagtccgag   3000

aggatcttcc agaaggaacc gtcatcatgt ggttagaagc ccacgatcct gatttaggtc   3060

agtctggtca ggtgagatac agccttctgg accacggaga aggaaacttc gatgtggata   3120

aactcagtgg agcagttagg atcgtccagc agttggactt tgagaagaag caagtgtata   3180

atctcactgt gagggccaaa gacaagggaa agccagtttc tctgtcttct acttgctatg   3240

ttgaagttga ggtggttgat gtgaatgaga acctgcaccc acccgtgttt tccagctttg   3300

tggaaaaggg gacagtgaaa gaagatgcac ctgttggttc attggtaatg acggtgtcgg   3360

ctcatgatga ggacgccaga agagatgggg agatccgata ctccattaga gatggctctg   3420

gcgttggtgt tttcaaaata ggtgaagaga caggtgtcat agagacgtca gatcgactgg   3480

accgtgaatc gacctcccat tattggctaa cagtctttgc aaccgatcag ggtgtcgtgc   3540

ctctttcatc gttcatagag atctacatag aggttgagga tgtcaatgac aatgcaccac   3600

agacatcaga gcctgtttat tacccagaaa tcatggaaaa ttctcctaaa gatgtatctg   3660

tggtccagat cgaggcattt gatccagatt cgagctctaa tgacaagctc atgtacaaaa   3720

ttacaagtgg aaatccacaa ggattctttt caatacatcc taaaacaggt ctcatcacaa   3780

ctacgtcaag gaagctagac cgagaacagc aagatgaaca catattagag gttactgtga   3840

cagacaatgg tagtcccccc aaatcaacca ttgcaagagt cattgtgaaa atccttgatg   3900

aaaatgacaa caaacctcag tttctgcaaa agttctacaa aatcagactc cctgagcggg   3960

aaaagccaga ccgagaaaga aatgccagac gggagccgct ctatcacgtc atagccaccg   4020

acaaggatga gggccccaat gcagaaatct cctacagcat cgaagacggg aatgagcatg   4080

gcaaattttt catcgaaccg aaaactggag tggtttcgtc caagaggttt tcagcagctg   4140

gagaatatga tattctttca attaaggcag ttgacaatgg tcgccctcaa aagtcatcaa   4200

ccaccagact ccatattgaa tggatctcca agcccaaacc gtccctggag cccatttcat   4260

ttgaagaatc attttttacc tttactgtga tggaaagtga ccccgttgct cacatgattg   4320

gagtaatatc tgtggagcct cctggcatac ccctttggtt tgacatcact ggtggcaact   4380

acgacagtca cttcgatgtg gacaagggaa ctggaaccat cattgttgcc aaacctcttg   4440

atgcagaaca gaagtcaaac tacaacctca cagtcgaggc tacagatgga accaccacta   4500

tcctcactca ggtattcatc aaagtaatag acacaaatga ccatcgtcct cagttttcta   4560

catcaaagta tgaagttgtt attcctgaag atacagcgcc agaaacagaa attttgcaaa   4620

tcagtgctgt ggatcaggat gagaaaaaca aactaatcta cactctgcag agcagtagag   4680

atccactgag tctcaagaaa tttcgtcttg atcctgcaac cggctctctc tatacttctg   4740

agaaactgga tcatgaagct gttcaccagc acaccctcac ggtcatggta cgagatcaag   4800

atgtgcctgt aaaacgcaac tttgcaagga ttgtggtcaa tgtcagcgac acgaatgacc   4860

acgccccgtg gttcaccgct tcctcctaca aagggcgggt ttatgaatcg gcagccgttg   4920

gctcagttgt gttgcaggtg acggctctgg acaaggacaa agggaaaaat gctgaagtgc   4980

tgtactcgat cgagtcagga aatattggaa attcttttat gattgatcct gtcttgggct   5040

ctattaaaac tgccaaagaa ttagatcgaa gtaaccaagc ggagtatgat ttaatggtaa   5100

aagctacaga taagggcagt ccaccaatga gtgaaataac ttctgtgcgt atctttgtca   5160

caattgctga caacgcctct ccgaagttta catcaaaaga atattctgtt gaacttagtg   5220

aaactgtcag cattgggagt ttcgttggga tggttacagc ccatagtcaa tcatcagtgg   5280

tgtatgaaat aaaagatgga aatacaggtg atgcttttga tattaatcca cattctggaa   5340

ctatcatcac tcagaaagcc ctggactttg aaactttgcc catttacaca ttgataatac   5400

aaggaactaa catggctggt ttgtccacta atacaacggt tctagttcac ttgcaggatg   5460

agaatgacaa cgcgccagtt tttatgcagg cagaatatac aggactcatt agtgaatcag   5520

cctcaattaa cagcgtggtc ctaacagaca ggaatgtccc actggtgatt cgagcagctg   5580

atgctgataa agactcaaat gctttgcttg tatatcacat tgttgaacca tctgtacaca   5640

catattttgc tattgattct agcactggtg ctattcatac agtactaagt ctggactatg   5700

aagaaacaag tatttttcac tttaccgtcc aagtgcatga catgggaacc ccacgtttat   5760

ttgctgagta tgcagcgaat gtaacagtac atgtaattga cattaatgac tgcccccctg   5820

tgtttgccaa gccattatat gaagcatctc ttttgttacc aacatacaaa ggagtaaaag   5880

tcatcacagt aaatgctaca gatgctgatt caagtgcatt ctcacagttg atttactcca   5940

tcaccgaagg caacatcggg gagaagtttt ctatggacta caagactggt gctctcactg   6000

tccaaaacac aactcagtta agaagccgct acgagctaac cgttagagct tccgatggca   6060

gatttgccgg ccttacctct gtcaaaatta atgtgaaaga aagcaaagaa agtcacctaa   6120

agtttaccca ggatgtctac tctgcggtag tgaaagagaa ttccaccgag gccgaaacat   6180

tagctgtcat tactgctatt gggaatccaa tcaatgagcc tttgttttat cacatcctca   6240

acccagatcg cagatttaaa ataagccgca cttcaggagt tctgtcaacc actggcacgc   6300

ccttcgatcg tgagcagcag gaggcgtttg atgtggttgt agaagtgaca gaggaacata   6360

agccttctgc agtggcccac gttgtcgtga aggtcattgt agaagaccaa aatgataatg   6420

cgccggtgtt tgtcaacctt ccctactacg ccgttgttaa agtggacact gaggtgggcc   6480

atgtcattcg ctatgtcact gctgtagaca gagacagtgg cagaaacggg gaagtgcatt   6540

actacctcaa ggaacatcat gaacactttc aaattggacc cttgggtgaa atttcactga   6600

aaaagcaatt tgagcttgac accttaaata aagaatatct tgttacagtg gttgcaaaag   6660

atggagggaa cccggccttt tcagcggaag ttatcgttcc gatcactgtc atgaataaag   6720

ccatgcctgt gtttgaaaaa cctttctaca gtgcagagat tgcagagagc atccaggtgc   6780

acagccctgt ggtccacgtg caggctaaca gcccggaagg cctgaaagtg ttctacagca   6840

tcacagacgg agaccctttc agccagttca ctattaactt caatactgga gttatcaatg   6900

tcatagctcc tctggacttt gaggcccacc cggcatataa gctgagcata cgcgcaactg   6960

actccttgac gggcgctcat gctgaagtat ttgtggacat catagtagac gacatcaatg   7020

ataaccctcc tgtgtttgct cagcagtctt atgcggtgac cctgtctgag gcatctgtaa   7080

ttggaacgtc tgttgttcaa gttagagcca ccgattctga ttcagaacca aatagaggaa   7140

tctcatacca gatgtttggg aatcacagca agagtcatga tcattttcat gtagacagca   7200

gcactggcct catctcacta ctcagaaccc tggattacga gcagtcccgg cagcacacga   7260

tttttgtgag ggcagttgat ggtggtatgc ccacgctgag cagtgatgtg attgtcacgg   7320

tggacgttac cgacctcaat gataatccac cactctttga acaacagatt tatgaagcca   7380

gaattagcga gcacgcccct catgggcatt tcgtgacctg tgtaaaagcc tatgatgcag   7440

acagttcaga catagacaag ttgcagtatt ccattctgtc tggcaatgat cataaacatt   7500

ttgtcattga cagtgcaaca gggattatca ccctctcaaa cctgcaccgg cacgccctga   7560

agccatttta cagtcttaac ctgtcagtgt ctgatggagt ttttagaagt tccacccagg   7620

ttcatgtaac tgtaattgga ggcaatttgc acagtcctgc tttccttcag aacgaatatg   7680

aagtggaact agctgaaaac gctcccctac ataccctggt gatggaggtg aaaactacgg   7740

atggggattc tggtatttat ggtcacgtta cttaccatat tgtaaatgac tttgccaaag   7800

acagatttta cataaatgag agaggacaga tatttacttt ggaaaaactt gatcgagaaa   7860

ccccggcgga gaaagtgatc tcagtccgtt taatggctaa ggatgctgga ggaaaagttg   7920

ctttctgcac cgtgaatgtc atccttacag atgacaatga caatgcacca caatttcgag   7980

caaccaaata cgaagtgaat atcgggtcca gtgctgctaa agggacttca gtcgttaaag   8040

ttcttgcaag tgatgccgat gagggctcca atgccgacat cacctatgcc attgaagcag   8100

actctgaaag tgtaaaagag aatttggaaa ttaacaaact gtccggcgta atcactacaa   8160

aggagagcct cattggcttg gaaaatgaat tc                                 8192


<210>  970
<211>  4588
<212>  PRT
<213>  Homosapiens

<400>  970

Met Gly Arg His Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Phe Gln 
1               5                   10                  15      


His Phe Gly Asp Ser Asp Gly Ser Gln Arg Leu Glu Gln Thr Pro Leu 
            20                  25                  30          


Gln Phe Thr His Leu Glu Tyr Asn Val Thr Val Gln Glu Asn Ser Ala 
        35                  40                  45              


Ala Lys Thr Tyr Val Gly His Pro Val Lys Met Gly Val Tyr Ile Thr 
    50                  55                  60                  


His Pro Ala Trp Glu Val Arg Tyr Lys Ile Val Ser Gly Asp Ser Glu 
65                  70                  75                  80  


Asn Leu Phe Lys Ala Glu Glu Tyr Ile Leu Gly Asp Phe Cys Phe Leu 
                85                  90                  95      


Arg Ile Arg Thr Lys Gly Gly Asn Thr Ala Ile Leu Asn Arg Glu Val 
            100                 105                 110         


Lys Asp His Tyr Thr Leu Ile Val Lys Ala Leu Glu Lys Asn Thr Asn 
        115                 120                 125             


Val Glu Ala Arg Thr Lys Val Arg Val Gln Val Leu Asp Thr Asn Asp 
    130                 135                 140                 


Leu Arg Pro Leu Phe Ser Pro Thr Ser Tyr Ser Val Ser Leu Pro Glu 
145                 150                 155                 160 


Asn Thr Ala Ile Arg Thr Ser Ile Ala Arg Val Ser Ala Thr Asp Ala 
                165                 170                 175     


Asp Ile Gly Thr Asn Gly Glu Phe Tyr Tyr Ser Phe Lys Asp Arg Thr 
            180                 185                 190         


Asp Met Phe Ala Ile His Pro Thr Ser Gly Val Ile Val Leu Thr Gly 
        195                 200                 205             


Arg Leu Asp Tyr Leu Glu Thr Lys Leu Tyr Glu Met Glu Ile Leu Ala 
    210                 215                 220                 


Ala Asp Arg Gly Met Lys Leu Tyr Gly Ser Ser Gly Ile Ser Ser Met 
225                 230                 235                 240 


Ala Lys Leu Thr Val His Ile Glu Gln Ala Asn Glu Cys Ala Pro Val 
                245                 250                 255     


Ile Thr Ala Val Thr Leu Ser Pro Ser Glu Leu Asp Arg Asp Pro Ala 
            260                 265                 270         


Tyr Ala Ile Val Thr Val Asp Asp Cys Asp Gln Gly Ala Asn Gly Asp 
        275                 280                 285             


Ile Ala Ser Leu Ser Ile Val Ala Gly Asp Leu Leu Gln Gln Phe Arg 
    290                 295                 300                 


Thr Val Arg Ser Phe Pro Gly Ser Lys Glu Tyr Lys Val Lys Ala Ile 
305                 310                 315                 320 


Gly Gly Ile Asp Trp Asp Ser His Pro Phe Gly Tyr Asn Leu Thr Leu 
                325                 330                 335     


Gln Ala Lys Asp Lys Gly Thr Pro Pro Gln Phe Ser Ser Val Lys Val 
            340                 345                 350         


Ile His Val Thr Ser Pro Gln Phe Lys Ala Gly Pro Val Lys Phe Glu 
        355                 360                 365             


Lys Asp Val Tyr Arg Ala Glu Ile Ser Glu Phe Ala Pro Pro Asn Thr 
    370                 375                 380                 


Pro Val Val Met Val Lys Ala Ile Pro Ala Tyr Ser His Leu Arg Tyr 
385                 390                 395                 400 


Val Phe Lys Ser Thr Pro Gly Lys Ala Lys Phe Ser Leu Asn Tyr Asn 
                405                 410                 415     


Thr Gly Leu Ile Ser Ile Leu Glu Pro Val Lys Arg Gln Gln Ala Ala 
            420                 425                 430         


His Phe Glu Leu Glu Val Thr Thr Ser Asp Arg Lys Ala Ser Thr Lys 
        435                 440                 445             


Val Leu Val Lys Val Leu Gly Ala Asn Ser Asn Pro Pro Glu Phe Thr 
    450                 455                 460                 


Gln Thr Ala Tyr Lys Ala Ala Phe Asp Glu Asn Val Pro Ile Gly Thr 
465                 470                 475                 480 


Thr Val Met Ser Leu Ser Ala Val Asp Pro Asp Glu Gly Glu Asn Gly 
                485                 490                 495     


Tyr Val Thr Tyr Ser Ile Ala Asn Leu Asn His Val Pro Phe Ala Ile 
            500                 505                 510         


Asp His Phe Thr Gly Ala Val Ser Thr Ser Glu Asn Leu Asp Tyr Glu 
        515                 520                 525             


Leu Met Pro Arg Val Tyr Thr Leu Arg Ile Arg Ala Ser Asp Trp Gly 
    530                 535                 540                 


Leu Pro Tyr Arg Arg Glu Val Glu Val Leu Ala Thr Ile Thr Leu Asn 
545                 550                 555                 560 


Asn Leu Asn Asp Asn Thr Pro Leu Phe Glu Lys Ile Asn Cys Glu Gly 
                565                 570                 575     


Thr Ile Pro Arg Asp Leu Gly Val Gly Glu Gln Ile Thr Thr Val Ser 
            580                 585                 590         


Ala Ile Asp Ala Asp Glu Leu Gln Leu Val Gln Tyr Gln Ile Glu Ala 
        595                 600                 605             


Gly Asn Glu Leu Asp Phe Phe Ser Leu Asn Pro Asn Ser Gly Val Leu 
    610                 615                 620                 


Ser Leu Lys Arg Ser Leu Met Asp Gly Leu Gly Ala Lys Val Ser Phe 
625                 630                 635                 640 


His Ser Leu Arg Ile Thr Ala Thr Asp Gly Glu Asn Phe Ala Thr Pro 
                645                 650                 655     


Leu Tyr Ile Asn Ile Thr Val Ala Ala Ser His Lys Leu Val Asn Leu 
            660                 665                 670         


Gln Cys Glu Glu Thr Gly Val Ala Lys Met Leu Ala Glu Lys Leu Leu 
        675                 680                 685             


Gln Ala Asn Lys Leu His Asn Gln Gly Glu Val Glu Asp Ile Phe Phe 
    690                 695                 700                 


Asp Ser His Ser Val Asn Ala His Ile Pro Gln Phe Arg Ser Thr Leu 
705                 710                 715                 720 


Pro Thr Gly Ile Gln Val Lys Glu Asn Gln Pro Val Gly Ser Ser Val 
                725                 730                 735     


Ile Phe Met Asn Ser Thr Asp Leu Asp Thr Gly Phe Asn Gly Lys Leu 
            740                 745                 750         


Val Tyr Ala Val Ser Gly Gly Asn Glu Asp Ser Cys Phe Met Ile Asp 
        755                 760                 765             


Met Glu Thr Gly Met Leu Lys Ile Leu Ser Pro Leu Asp Arg Glu Thr 
    770                 775                 780                 


Thr Asp Lys Tyr Thr Leu Asn Ile Thr Val Tyr Asp Leu Gly Ile Pro 
785                 790                 795                 800 


Gln Lys Ala Ala Trp Arg Leu Leu His Val Val Val Val Asp Ala Asn 
                805                 810                 815     


Asp Asn Pro Pro Glu Phe Leu Gln Glu Ser Tyr Phe Val Glu Val Ser 
            820                 825                 830         


Glu Asp Lys Glu Val His Ser Glu Ile Ile Gln Val Glu Ala Thr Asp 
        835                 840                 845             


Lys Asp Leu Gly Pro Asn Gly His Val Thr Tyr Ser Ile Val Thr Asp 
    850                 855                 860                 


Thr Asp Thr Phe Ser Ile Asp Ser Val Thr Gly Val Val Asn Ile Ala 
865                 870                 875                 880 


Arg Pro Leu Asp Arg Glu Leu Gln His Glu His Ser Leu Lys Ile Glu 
                885                 890                 895     


Ala Arg Asp Gln Ala Arg Glu Glu Pro Gln Leu Phe Ser Thr Val Val 
            900                 905                 910         


Val Lys Val Ser Leu Glu Asp Val Asn Asp Asn Pro Pro Thr Phe Ile 
        915                 920                 925             


Pro Pro Asn Tyr Arg Val Lys Val Arg Glu Asp Leu Pro Glu Gly Thr 
    930                 935                 940                 


Val Ile Met Trp Leu Glu Ala His Asp Pro Asp Leu Gly Gln Ser Gly 
945                 950                 955                 960 


Gln Val Arg Tyr Ser Leu Leu Asp His Gly Glu Gly Asn Phe Asp Val 
                965                 970                 975     


Asp Lys Leu Ser Gly Ala Val Arg Ile Val Gln Gln Leu Asp Phe Glu 
            980                 985                 990         


Lys Lys Gln Val Tyr Asn Leu Thr  Val Arg Ala Lys Asp  Lys Gly Lys 
        995                 1000                 1005             


Pro Val  Ser Leu Ser Ser Thr  Cys Tyr Val Glu Val  Glu Val Val 
    1010                 1015                 1020             


Asp Val  Asn Glu Asn Leu His  Pro Pro Val Phe Ser  Ser Phe Val 
    1025                 1030                 1035             


Glu Lys  Gly Thr Val Lys Glu  Asp Ala Pro Val Gly  Ser Leu Val 
    1040                 1045                 1050             


Met Thr  Val Ser Ala His Asp  Glu Asp Ala Arg Arg  Asp Gly Glu 
    1055                 1060                 1065             


Ile Arg  Tyr Ser Ile Arg Asp  Gly Ser Gly Val Gly  Val Phe Lys 
    1070                 1075                 1080             


Ile Gly  Glu Glu Thr Gly Val  Ile Glu Thr Ser Asp  Arg Leu Asp 
    1085                 1090                 1095             


Arg Glu  Ser Thr Ser His Tyr  Trp Leu Thr Val Phe  Ala Thr Asp 
    1100                 1105                 1110             


Gln Gly  Val Val Pro Leu Ser  Ser Phe Ile Glu Ile  Tyr Ile Glu 
    1115                 1120                 1125             


Val Glu  Asp Val Asn Asp Asn  Ala Pro Gln Thr Ser  Glu Pro Val 
    1130                 1135                 1140             


Tyr Tyr  Pro Glu Ile Met Glu  Asn Ser Pro Lys Asp  Val Ser Val 
    1145                 1150                 1155             


Val Gln  Ile Glu Ala Phe Asp  Pro Asp Ser Ser Ser  Asn Asp Lys 
    1160                 1165                 1170             


Leu Met  Tyr Lys Ile Thr Ser  Gly Asn Pro Gln Gly  Phe Phe Ser 
    1175                 1180                 1185             


Ile His  Pro Lys Thr Gly Leu  Ile Thr Thr Thr Ser  Arg Lys Leu 
    1190                 1195                 1200             


Asp Arg  Glu Gln Gln Asp Glu  His Ile Leu Glu Val  Thr Val Thr 
    1205                 1210                 1215             


Asp Asn  Gly Ser Pro Pro Lys  Ser Thr Ile Ala Arg  Val Ile Val 
    1220                 1225                 1230             


Lys Ile  Leu Asp Glu Asn Asp  Asn Lys Pro Gln Phe  Leu Gln Lys 
    1235                 1240                 1245             


Phe Tyr  Lys Ile Arg Leu Pro  Glu Arg Glu Lys Pro  Asp Arg Glu 
    1250                 1255                 1260             


Arg Asn  Ala Arg Arg Glu Pro  Leu Tyr His Val Ile  Ala Thr Asp 
    1265                 1270                 1275             


Lys Asp  Glu Gly Pro Asn Ala  Glu Ile Ser Tyr Ser  Ile Glu Asp 
    1280                 1285                 1290             


Gly Asn  Glu His Gly Lys Phe  Phe Ile Glu Pro Lys  Thr Gly Val 
    1295                 1300                 1305             


Val Ser  Ser Lys Arg Phe Ser  Ala Ala Gly Glu Tyr  Asp Ile Leu 
    1310                 1315                 1320             


Ser Ile  Lys Ala Val Asp Asn  Gly Arg Pro Gln Lys  Ser Ser Thr 
    1325                 1330                 1335             


Thr Arg  Leu His Ile Glu Trp  Ile Ser Lys Pro Lys  Pro Ser Leu 
    1340                 1345                 1350             


Glu Pro  Ile Ser Phe Glu Glu  Ser Phe Phe Thr Phe  Thr Val Met 
    1355                 1360                 1365             


Glu Ser  Asp Pro Val Ala His  Met Ile Gly Val Ile  Ser Val Glu 
    1370                 1375                 1380             


Pro Pro  Gly Ile Pro Leu Trp  Phe Asp Ile Thr Gly  Gly Asn Tyr 
    1385                 1390                 1395             


Asp Ser  His Phe Asp Val Asp  Lys Gly Thr Gly Thr  Ile Ile Val 
    1400                 1405                 1410             


Ala Lys  Pro Leu Asp Ala Glu  Gln Lys Ser Asn Tyr  Asn Leu Thr 
    1415                 1420                 1425             


Val Glu  Ala Thr Asp Gly Thr  Thr Thr Ile Leu Thr  Gln Val Phe 
    1430                 1435                 1440             


Ile Lys  Val Ile Asp Thr Asn  Asp His Arg Pro Gln  Phe Ser Thr 
    1445                 1450                 1455             


Ser Lys  Tyr Glu Val Val Ile  Pro Glu Asp Thr Ala  Pro Glu Thr 
    1460                 1465                 1470             


Glu Ile  Leu Gln Ile Ser Ala  Val Asp Gln Asp Glu  Lys Asn Lys 
    1475                 1480                 1485             


Leu Ile  Tyr Thr Leu Gln Ser  Ser Arg Asp Pro Leu  Ser Leu Lys 
    1490                 1495                 1500             


Lys Phe  Arg Leu Asp Pro Ala  Thr Gly Ser Leu Tyr  Thr Ser Glu 
    1505                 1510                 1515             


Lys Leu  Asp His Glu Ala Val  His Gln His Thr Leu  Thr Val Met 
    1520                 1525                 1530             


Val Arg  Asp Gln Asp Val Pro  Val Lys Arg Asn Phe  Ala Arg Ile 
    1535                 1540                 1545             


Val Val  Asn Val Ser Asp Thr  Asn Asp His Ala Pro  Trp Phe Thr 
    1550                 1555                 1560             


Ala Ser  Ser Tyr Lys Gly Arg  Val Tyr Glu Ser Ala  Ala Val Gly 
    1565                 1570                 1575             


Ser Val  Val Leu Gln Val Thr  Ala Leu Asp Lys Asp  Lys Gly Lys 
    1580                 1585                 1590             


Asn Ala  Glu Val Leu Tyr Ser  Ile Glu Ser Gly Asn  Ile Gly Asn 
    1595                 1600                 1605             


Ser Phe  Met Ile Asp Pro Val  Leu Gly Ser Ile Lys  Thr Ala Lys 
    1610                 1615                 1620             


Glu Leu  Asp Arg Ser Asn Gln  Ala Glu Tyr Asp Leu  Met Val Lys 
    1625                 1630                 1635             


Ala Thr  Asp Lys Gly Ser Pro  Pro Met Ser Glu Ile  Thr Ser Val 
    1640                 1645                 1650             


Arg Ile  Phe Val Thr Ile Ala  Asp Asn Ala Ser Pro  Lys Phe Thr 
    1655                 1660                 1665             


Ser Lys  Glu Tyr Ser Val Glu  Leu Ser Glu Thr Val  Ser Ile Gly 
    1670                 1675                 1680             


Ser Phe  Val Gly Met Val Thr  Ala His Ser Gln Ser  Ser Val Val 
    1685                 1690                 1695             


Tyr Glu  Ile Lys Asp Gly Asn  Thr Gly Asp Ala Phe  Asp Ile Asn 
    1700                 1705                 1710             


Pro His  Ser Gly Thr Ile Ile  Thr Gln Lys Ala Leu  Asp Phe Glu 
    1715                 1720                 1725             


Thr Leu  Pro Ile Tyr Thr Leu  Ile Ile Gln Gly Thr  Asn Met Ala 
    1730                 1735                 1740             


Gly Leu  Ser Thr Asn Thr Thr  Val Leu Val His Leu  Gln Asp Glu 
    1745                 1750                 1755             


Asn Asp  Asn Ala Pro Val Phe  Met Gln Ala Glu Tyr  Thr Gly Leu 
    1760                 1765                 1770             


Ile Ser  Glu Ser Ala Ser Ile  Asn Ser Val Val Leu  Thr Asp Arg 
    1775                 1780                 1785             


Asn Val  Pro Leu Val Ile Arg  Ala Ala Asp Ala Asp  Lys Asp Ser 
    1790                 1795                 1800             


Asn Ala  Leu Leu Val Tyr His  Ile Val Glu Pro Ser  Val His Thr 
    1805                 1810                 1815             


Tyr Phe  Ala Ile Asp Ser Ser  Thr Gly Ala Ile His  Thr Val Leu 
    1820                 1825                 1830             


Ser Leu  Asp Tyr Glu Glu Thr  Ser Ile Phe His Phe  Thr Val Gln 
    1835                 1840                 1845             


Val His  Asp Met Gly Thr Pro  Arg Leu Phe Ala Glu  Tyr Ala Ala 
    1850                 1855                 1860             


Asn Val  Thr Val His Val Ile  Asp Ile Asn Asp Cys  Pro Pro Val 
    1865                 1870                 1875             


Phe Ala  Lys Pro Leu Tyr Glu  Ala Ser Leu Leu Leu  Pro Thr Tyr 
    1880                 1885                 1890             


Lys Gly  Val Lys Val Ile Thr  Val Asn Ala Thr Asp  Ala Asp Ser 
    1895                 1900                 1905             


Ser Ala  Phe Ser Gln Leu Ile  Tyr Ser Ile Thr Glu  Gly Asn Ile 
    1910                 1915                 1920             


Gly Glu  Lys Phe Ser Met Asp  Tyr Lys Thr Gly Ala  Leu Thr Val 
    1925                 1930                 1935             


Gln Asn  Thr Thr Gln Leu Arg  Ser Arg Tyr Glu Leu  Thr Val Arg 
    1940                 1945                 1950             


Ala Ser  Asp Gly Arg Phe Ala  Gly Leu Thr Ser Val  Lys Ile Asn 
    1955                 1960                 1965             


Val Lys  Glu Ser Lys Glu Ser  His Leu Lys Phe Thr  Gln Asp Val 
    1970                 1975                 1980             


Tyr Ser  Ala Val Val Lys Glu  Asn Ser Thr Glu Ala  Glu Thr Leu 
    1985                 1990                 1995             


Ala Val  Ile Thr Ala Ile Gly  Asn Pro Ile Asn Glu  Pro Leu Phe 
    2000                 2005                 2010             


Tyr His  Ile Leu Asn Pro Asp  Arg Arg Phe Lys Ile  Ser Arg Thr 
    2015                 2020                 2025             


Ser Gly  Val Leu Ser Thr Thr  Gly Thr Pro Phe Asp  Arg Glu Gln 
    2030                 2035                 2040             


Gln Glu  Ala Phe Asp Val Val  Val Glu Val Thr Glu  Glu His Lys 
    2045                 2050                 2055             


Pro Ser  Ala Val Ala His Val  Val Val Lys Val Ile  Val Glu Asp 
    2060                 2065                 2070             


Gln Asn  Asp Asn Ala Pro Val  Phe Val Asn Leu Pro  Tyr Tyr Ala 
    2075                 2080                 2085             


Val Val  Lys Val Asp Thr Glu  Val Gly His Val Ile  Arg Tyr Val 
    2090                 2095                 2100             


Thr Ala  Val Asp Arg Asp Ser  Gly Arg Asn Gly Glu  Val His Tyr 
    2105                 2110                 2115             


Tyr Leu  Lys Glu His His Glu  His Phe Gln Ile Gly  Pro Leu Gly 
    2120                 2125                 2130             


Glu Ile  Ser Leu Lys Lys Gln  Phe Glu Leu Asp Thr  Leu Asn Lys 
    2135                 2140                 2145             


Glu Tyr  Leu Val Thr Val Val  Ala Lys Asp Gly Gly  Asn Pro Ala 
    2150                 2155                 2160             


Phe Ser  Ala Glu Val Ile Val  Pro Ile Thr Val Met  Asn Lys Ala 
    2165                 2170                 2175             


Met Pro  Val Phe Glu Lys Pro  Phe Tyr Ser Ala Glu  Ile Ala Glu 
    2180                 2185                 2190             


Ser Ile  Gln Val His Ser Pro  Val Val His Val Gln  Ala Asn Ser 
    2195                 2200                 2205             


Pro Glu  Gly Leu Lys Val Phe  Tyr Ser Ile Thr Asp  Gly Asp Pro 
    2210                 2215                 2220             


Phe Ser  Gln Phe Thr Ile Asn  Phe Asn Thr Gly Val  Ile Asn Val 
    2225                 2230                 2235             


Ile Ala  Pro Leu Asp Phe Glu  Ala His Pro Ala Tyr  Lys Leu Ser 
    2240                 2245                 2250             


Ile Arg  Ala Thr Asp Ser Leu  Thr Gly Ala His Ala  Glu Val Phe 
    2255                 2260                 2265             


Val Asp  Ile Ile Val Asp Asp  Ile Asn Asp Asn Pro  Pro Val Phe 
    2270                 2275                 2280             


Ala Gln  Gln Ser Tyr Ala Val  Thr Leu Ser Glu Ala  Ser Val Ile 
    2285                 2290                 2295             


Gly Thr  Ser Val Val Gln Val  Arg Ala Thr Asp Ser  Asp Ser Glu 
    2300                 2305                 2310             


Pro Asn  Arg Gly Ile Ser Tyr  Gln Met Phe Gly Asn  His Ser Lys 
    2315                 2320                 2325             


Ser His  Asp His Phe His Val  Asp Ser Ser Thr Gly  Leu Ile Ser 
    2330                 2335                 2340             


Leu Leu  Arg Thr Leu Asp Tyr  Glu Gln Ser Arg Gln  His Thr Ile 
    2345                 2350                 2355             


Phe Val  Arg Ala Val Asp Gly  Gly Met Pro Thr Leu  Ser Ser Asp 
    2360                 2365                 2370             


Val Ile  Val Thr Val Asp Val  Thr Asp Leu Asn Asp  Asn Pro Pro 
    2375                 2380                 2385             


Leu Phe  Glu Gln Gln Ile Tyr  Glu Ala Arg Ile Ser  Glu His Ala 
    2390                 2395                 2400             


Pro His  Gly His Phe Val Thr  Cys Val Lys Ala Tyr  Asp Ala Asp 
    2405                 2410                 2415             


Ser Ser  Asp Ile Asp Lys Leu  Gln Tyr Ser Ile Leu  Ser Gly Asn 
    2420                 2425                 2430             


Asp His  Lys His Phe Val Ile  Asp Ser Ala Thr Gly  Ile Ile Thr 
    2435                 2440                 2445             


Leu Ser  Asn Leu His Arg His  Ala Leu Lys Pro Phe  Tyr Ser Leu 
    2450                 2455                 2460             


Asn Leu  Ser Val Ser Asp Gly  Val Phe Arg Ser Ser  Thr Gln Val 
    2465                 2470                 2475             


His Val  Thr Val Ile Gly Gly  Asn Leu His Ser Pro  Ala Phe Leu 
    2480                 2485                 2490             


Gln Asn  Glu Tyr Glu Val Glu  Leu Ala Glu Asn Ala  Pro Leu His 
    2495                 2500                 2505             


Thr Leu  Val Met Glu Val Lys  Thr Thr Asp Gly Asp  Ser Gly Ile 
    2510                 2515                 2520             


Tyr Gly  His Val Thr Tyr His  Ile Val Asn Asp Phe  Ala Lys Asp 
    2525                 2530                 2535             


Arg Phe  Tyr Ile Asn Glu Arg  Gly Gln Ile Phe Thr  Leu Glu Lys 
    2540                 2545                 2550             


Leu Asp  Arg Glu Thr Pro Ala  Glu Lys Val Ile Ser  Val Arg Leu 
    2555                 2560                 2565             


Met Ala  Lys Asp Ala Gly Gly  Lys Val Ala Phe Cys  Thr Val Asn 
    2570                 2575                 2580             


Val Ile  Leu Thr Asp Asp Asn  Asp Asn Ala Pro Gln  Phe Arg Ala 
    2585                 2590                 2595             


Thr Lys  Tyr Glu Val Asn Ile  Gly Ser Ser Ala Ala  Lys Gly Thr 
    2600                 2605                 2610             


Ser Val  Val Lys Val Leu Ala  Ser Asp Ala Asp Glu  Gly Ser Asn 
    2615                 2620                 2625             


Ala Asp  Ile Thr Tyr Ala Ile  Glu Ala Asp Ser Glu  Ser Val Lys 
    2630                 2635                 2640             


Glu Asn  Leu Glu Ile Asn Lys  Leu Ser Gly Val Ile  Thr Thr Lys 
    2645                 2650                 2655             


Glu Ser  Leu Ile Gly Leu Glu  Asn Glu Phe Phe Thr  Phe Phe Val 
    2660                 2665                 2670             


Arg Ala  Val Asp Asn Gly Ser  Pro Ser Lys Glu Ser  Val Val Leu 
    2675                 2680                 2685             


Val Tyr  Val Lys Ile Leu Pro  Pro Glu Met Gln Leu  Pro Lys Phe 
    2690                 2695                 2700             


Ser Glu  Pro Phe Tyr Thr Phe  Thr Val Ser Glu Asp  Val Pro Ile 
    2705                 2710                 2715             


Gly Thr  Glu Ile Asp Leu Ile  Arg Ala Glu His Ser  Gly Thr Val 
    2720                 2725                 2730             


Leu Tyr  Ser Leu Val Lys Gly  Asn Thr Pro Glu Ser  Asn Arg Asp 
    2735                 2740                 2745             


Glu Ser  Phe Val Ile Asp Arg  Gln Ser Gly Arg Leu  Lys Leu Glu 
    2750                 2755                 2760             


Lys Ser  Leu Asp His Glu Thr  Thr Lys Trp Tyr Gln  Phe Ser Ile 
    2765                 2770                 2775             


Leu Ala  Arg Cys Thr Gln Asp  Asp His Glu Met Val  Ala Ser Val 
    2780                 2785                 2790             


Asp Val  Ser Ile Gln Val Lys  Asp Ala Asn Asp Asn  Ser Pro Val 
    2795                 2800                 2805             


Phe Glu  Ser Ser Pro Tyr Glu  Ala Phe Ile Val Glu  Asn Leu Pro 
    2810                 2815                 2820             


Gly Gly  Ser Arg Val Ile Gln  Ile Arg Ala Ser Asp  Ala Asp Ser 
    2825                 2830                 2835             


Gly Thr  Asn Gly Gln Val Met  Tyr Ser Leu Asp Gln  Ser Gln Ser 
    2840                 2845                 2850             


Val Glu  Val Ile Glu Ser Phe  Ala Ile Asn Met Glu  Thr Gly Trp 
    2855                 2860                 2865             


Ile Thr  Thr Leu Lys Glu Leu  Asp His Glu Lys Arg  Asp Asn Tyr 
    2870                 2875                 2880             


Gln Ile  Lys Val Val Ala Ser  Asp His Gly Glu Lys  Ile Gln Leu 
    2885                 2890                 2895             


Ser Ser  Thr Ala Ile Val Asp  Val Thr Val Thr Asp  Val Asn Asp 
    2900                 2905                 2910             


Ser Pro  Pro Arg Phe Thr Ala  Glu Ile Tyr Lys Gly  Thr Val Ser 
    2915                 2920                 2925             


Glu Asp  Asp Pro Gln Gly Gly  Val Ile Ala Ile Leu  Ser Thr Thr 
    2930                 2935                 2940             


Asp Ala  Asp Ser Glu Glu Ile  Asn Arg Gln Val Thr  Tyr Phe Ile 
    2945                 2950                 2955             


Thr Gly  Gly Asp Pro Leu Gly  Gln Phe Ala Val Glu  Thr Ile Gln 
    2960                 2965                 2970             


Asn Glu  Trp Lys Val Tyr Val  Lys Lys Pro Leu Asp  Arg Glu Lys 
    2975                 2980                 2985             


Arg Asp  Asn Tyr Leu Leu Thr  Ile Thr Ala Thr Asp  Gly Thr Phe 
    2990                 2995                 3000             


Ser Ser  Lys Ala Ile Val Glu  Val Lys Val Leu Asp  Ala Asn Asp 
    3005                 3010                 3015             


Asn Ser  Pro Val Cys Glu Lys  Thr Leu Tyr Ser Asp  Thr Ile Pro 
    3020                 3025                 3030             


Glu Asp  Val Leu Pro Gly Lys  Leu Ile Met Gln Ile  Ser Ala Thr 
    3035                 3040                 3045             


Asp Ala  Asp Ile Arg Ser Asn  Ala Glu Ile Thr Tyr  Thr Leu Leu 
    3050                 3055                 3060             


Gly Ser  Gly Ala Glu Lys Phe  Lys Leu Asn Pro Asp  Thr Gly Glu 
    3065                 3070                 3075             


Leu Lys  Thr Ser Thr Pro Leu  Asp Arg Glu Glu Gln  Ala Val Tyr 
    3080                 3085                 3090             


His Leu  Leu Val Arg Ala Thr  Asp Gly Gly Gly Arg  Phe Cys Gln 
    3095                 3100                 3105             


Ala Ser  Ile Val Leu Thr Leu  Glu Asp Val Asn Asp  Asn Ala Pro 
    3110                 3115                 3120             


Glu Phe  Ser Ala Asp Pro Tyr  Ala Ile Thr Val Phe  Glu Asn Thr 
    3125                 3130                 3135             


Glu Pro  Gly Thr Leu Leu Thr  Arg Val Gln Ala Thr  Asp Ala Asp 
    3140                 3145                 3150             


Ala Gly  Leu Asn Arg Lys Ile  Leu Tyr Ser Leu Ile  Asp Ser Ala 
    3155                 3160                 3165             


Asp Gly  Gln Phe Ser Ile Asn  Glu Leu Ser Gly Ile  Ile Gln Leu 
    3170                 3175                 3180             


Glu Lys  Pro Leu Asp Arg Glu  Leu Gln Ala Val Tyr  Thr Leu Ser 
    3185                 3190                 3195             


Leu Lys  Ala Val Asp Gln Gly  Leu Pro Arg Arg Leu  Thr Ala Thr 
    3200                 3205                 3210             


Gly Thr  Val Ile Val Ser Val  Leu Asp Ile Asn Asp  Asn Pro Pro 
    3215                 3220                 3225             


Val Phe  Glu Tyr Arg Glu Tyr  Gly Ala Thr Val Ser  Glu Asp Ile 
    3230                 3235                 3240             


Leu Val  Gly Thr Glu Val Leu  Gln Val Tyr Ala Ala  Ser Arg Asp 
    3245                 3250                 3255             


Ile Glu  Ala Asn Ala Glu Ile  Thr Tyr Ser Ile Ile  Ser Gly Asn 
    3260                 3265                 3270             


Glu His  Gly Lys Phe Ser Ile  Asp Ser Lys Thr Gly  Ala Val Phe 
    3275                 3280                 3285             


Ile Ile  Glu Asn Leu Asp Tyr  Glu Ser Ser His Glu  Tyr Tyr Leu 
    3290                 3295                 3300             


Thr Val  Glu Ala Thr Asp Gly  Gly Thr Pro Ser Leu  Ser Asp Val 
    3305                 3310                 3315             


Ala Thr  Val Asn Val Asn Val  Thr Asp Ile Asn Asp  Asn Thr Pro 
    3320                 3325                 3330             


Val Phe  Ser Gln Asp Thr Tyr  Thr Thr Val Ile Ser  Glu Asp Ala 
    3335                 3340                 3345             


Val Leu  Glu Gln Ser Val Ile  Thr Val Met Ala Asp  Asp Ala Asp 
    3350                 3355                 3360             


Gly Pro  Ser Asn Ser His Ile  His Tyr Ser Ile Ile  Asp Gly Asn 
    3365                 3370                 3375             


Gln Gly  Ser Ser Phe Thr Ile  Asp Pro Val Arg Gly  Glu Val Lys 
    3380                 3385                 3390             


Val Thr  Lys Leu Leu Asp Arg  Glu Thr Ile Ser Gly  Tyr Thr Leu 
    3395                 3400                 3405             


Thr Val  Gln Ala Ser Asp Asn  Gly Ser Pro Pro Arg  Val Asn Thr 
    3410                 3415                 3420             


Thr Thr  Val Asn Ile Asp Val  Ser Asp Val Asn Asp  Asn Ala Pro 
    3425                 3430                 3435             


Val Phe  Ser Arg Gly Asn Tyr  Ser Val Ile Ile Gln  Glu Asn Lys 
    3440                 3445                 3450             


Pro Val  Gly Phe Ser Val Leu  Gln Leu Val Val Thr  Asp Glu Asp 
    3455                 3460                 3465             


Ser Ser  His Asn Gly Pro Pro  Phe Phe Phe Thr Ile  Val Thr Gly 
    3470                 3475                 3480             


Asn Asp  Glu Lys Ala Phe Glu  Val Asn Pro Gln Gly  Val Leu Leu 
    3485                 3490                 3495             


Thr Ser  Ser Ala Ile Lys Arg  Lys Glu Lys Asp His  Tyr Leu Leu 
    3500                 3505                 3510             


Gln Val  Lys Val Ala Asp Asn  Gly Lys Pro Gln Leu  Ser Ser Leu 
    3515                 3520                 3525             


Thr Tyr  Ile Asp Ile Arg Val  Ile Glu Glu Ser Ile  Tyr Pro Pro 
    3530                 3535                 3540             


Ala Ile  Leu Pro Leu Glu Ile  Phe Ile Thr Ser Ser  Gly Glu Glu 
    3545                 3550                 3555             


Tyr Ser  Gly Gly Val Ile Gly  Lys Ile His Ala Thr  Asp Gln Asp 
    3560                 3565                 3570             


Val Tyr  Asp Thr Leu Thr Tyr  Ser Leu Asp Pro Gln  Met Asp Asn 
    3575                 3580                 3585             


Leu Phe  Ser Val Ser Ser Thr  Gly Gly Lys Leu Ile  Ala His Lys 
    3590                 3595                 3600             


Lys Leu  Asp Ile Gly Gln Tyr  Leu Leu Asn Val Ser  Val Thr Asp 
    3605                 3610                 3615             


Gly Lys  Phe Thr Thr Val Ala  Asp Ile Thr Val His  Ile Arg Gln 
    3620                 3625                 3630             


Val Thr  Gln Glu Met Leu Asn  His Thr Ile Ala Ile  Arg Phe Ala 
    3635                 3640                 3645             


Asn Leu  Thr Pro Glu Glu Phe  Val Gly Asp Tyr Trp  Arg Asn Phe 
    3650                 3655                 3660             


Gln Arg  Ala Leu Arg Asn Ile  Leu Gly Val Arg Arg  Asn Asp Ile 
    3665                 3670                 3675             


Gln Ile  Val Ser Leu Gln Ser  Ser Glu Pro His Pro  His Leu Asp 
    3680                 3685                 3690             


Val Leu  Leu Phe Val Glu Lys  Pro Gly Ser Ala Gln  Ile Ser Thr 
    3695                 3700                 3705             


Lys Gln  Leu Leu His Lys Ile  Asn Ser Ser Val Thr  Asp Ile Glu 
    3710                 3715                 3720             


Glu Ile  Ile Gly Val Arg Ile  Leu Asn Val Phe Gln  Lys Leu Cys 
    3725                 3730                 3735             


Ala Gly  Leu Asp Cys Pro Trp  Lys Phe Cys Asp Glu  Lys Val Ser 
    3740                 3745                 3750             


Val Asp  Glu Ser Val Met Ser  Thr His Ser Thr Ala  Arg Leu Ser 
    3755                 3760                 3765             


Phe Val  Thr Pro Arg His His  Arg Ala Ala Val Cys  Leu Cys Lys 
    3770                 3775                 3780             


Glu Gly  Arg Cys Pro Pro Val  His His Gly Cys Glu  Asp Asp Pro 
    3785                 3790                 3795             


Cys Pro  Glu Gly Ser Glu Cys  Val Ser Asp Pro Trp  Glu Glu Lys 
    3800                 3805                 3810             


His Thr  Cys Val Cys Pro Ser  Gly Arg Phe Gly Gln  Cys Pro Gly 
    3815                 3820                 3825             


Ser Ser  Ser Met Thr Leu Thr  Gly Asn Ser Tyr Val  Lys Tyr Arg 
    3830                 3835                 3840             


Leu Thr  Glu Asn Glu Asn Lys  Leu Glu Met Lys Leu  Thr Met Arg 
    3845                 3850                 3855             


Leu Arg  Thr Tyr Ser Thr His  Ala Val Val Met Tyr  Ala Arg Gly 
    3860                 3865                 3870             


Thr Asp  Tyr Ser Ile Leu Glu  Ile His His Gly Arg  Leu Gln Tyr 
    3875                 3880                 3885             


Lys Phe  Asp Cys Gly Ser Gly  Pro Gly Ile Val Ser  Val Gln Ser 
    3890                 3895                 3900             


Ile Gln  Val Asn Asp Gly Gln  Trp His Ala Val Ala  Leu Glu Val 
    3905                 3910                 3915             


Asn Gly  Asn Tyr Ala Arg Leu  Val Leu Asp Gln Val  His Thr Ala 
    3920                 3925                 3930             


Ser Gly  Thr Ala Pro Gly Thr  Leu Lys Thr Leu Asn  Leu Asp Asn 
    3935                 3940                 3945             


Tyr Val  Phe Phe Gly Gly His  Ile Arg Gln Gln Gly  Thr Arg His 
    3950                 3955                 3960             


Gly Arg  Ser Pro Gln Val Gly  Asn Gly Phe Arg Gly  Cys Met Asp 
    3965                 3970                 3975             


Ser Ile  Tyr Leu Asn Gly Gln  Glu Leu Pro Leu Asn  Ser Lys Pro 
    3980                 3985                 3990             


Arg Ser  Tyr Ala His Ile Glu  Glu Ser Val Asp Val  Ser Pro Gly 
    3995                 4000                 4005             


Cys Phe  Leu Thr Ala Thr Glu  Asp Cys Ala Ser Asn  Pro Cys Gln 
    4010                 4015                 4020             


Asn Gly  Gly Val Cys Asn Pro  Ser Pro Ala Gly Gly  Tyr Tyr Cys 
    4025                 4030                 4035             


Lys Cys  Ser Ala Leu Tyr Ile  Gly Thr His Cys Glu  Ile Ser Val 
    4040                 4045                 4050             


Asn Pro  Cys Ser Ser Lys Pro  Cys Leu Tyr Gly Gly  Thr Cys Val 
    4055                 4060                 4065             


Val Asp  Asn Gly Gly Phe Val  Cys Gln Cys Arg Gly  Leu Tyr Thr 
    4070                 4075                 4080             


Gly Gln  Arg Cys Gln Leu Ser  Pro Tyr Cys Lys Asp  Glu Pro Cys 
    4085                 4090                 4095             


Lys Asn  Gly Gly Thr Cys Phe  Asp Ser Leu Asp Gly  Ala Val Cys 
    4100                 4105                 4110             


Gln Cys  Asp Ser Gly Phe Arg  Gly Glu Arg Cys Gln  Ser Asp Ile 
    4115                 4120                 4125             


Asp Glu  Cys Ser Gly Asn Pro  Cys Leu His Gly Ala  Leu Cys Glu 
    4130                 4135                 4140             


Asn Thr  His Gly Ser Tyr His  Cys Asn Cys Ser His  Glu Tyr Arg 
    4145                 4150                 4155             


Gly Arg  His Cys Glu Asp Ala  Ala Pro Asn Gln Tyr  Val Ser Thr 
    4160                 4165                 4170             


Pro Trp  Asn Ile Gly Leu Ala  Glu Gly Ile Gly Ile  Val Val Phe 
    4175                 4180                 4185             


Val Ala  Gly Ile Phe Leu Leu  Val Val Val Phe Val  Leu Cys Arg 
    4190                 4195                 4200             


Lys Met  Ile Ser Arg Lys Lys  Lys His Gln Ala Glu  Pro Lys Asp 
    4205                 4210                 4215             


Lys His  Leu Gly Pro Ala Thr  Ala Phe Leu Gln Arg  Pro Tyr Phe 
    4220                 4225                 4230             


Asp Ser  Lys Leu Asn Lys Asn  Ile Tyr Ser Asp Ile  Pro Pro Gln 
    4235                 4240                 4245             


Val Pro  Val Arg Pro Ile Ser  Tyr Thr Pro Ser Ile  Pro Ser Asp 
    4250                 4255                 4260             


Ser Arg  Asn Asn Leu Asp Arg  Asn Ser Phe Glu Gly  Ser Ala Ile 
    4265                 4270                 4275             


Pro Glu  His Pro Glu Phe Ser  Thr Phe Asn Pro Glu  Ser Val His 
    4280                 4285                 4290             


Gly His  Arg Lys Ala Val Ala  Val Cys Ser Val Ala  Pro Asn Leu 
    4295                 4300                 4305             


Pro Pro  Pro Pro Pro Ser Asn  Ser Pro Ser Asp Ser  Asp Ser Ile 
    4310                 4315                 4320             


Gln Lys  Pro Ser Trp Asp Phe  Asp Tyr Asp Thr Lys  Val Val Asp 
    4325                 4330                 4335             


Leu Asp  Pro Cys Leu Ser Lys  Lys Pro Leu Glu Glu  Lys Pro Ser 
    4340                 4345                 4350             


Gln Pro  Tyr Ser Ala Arg Glu  Ser Leu Ser Glu Val  Gln Ser Leu 
    4355                 4360                 4365             


Ser Ser  Phe Gln Ser Glu Ser  Cys Asp Asp Asn Gly  Tyr His Trp 
    4370                 4375                 4380             


Asp Thr  Ser Asp Trp Met Pro  Ser Val Pro Leu Pro  Asp Ile Gln 
    4385                 4390                 4395             


Glu Phe  Pro Asn Tyr Glu Val  Ile Asp Glu Gln Thr  Pro Leu Tyr 
    4400                 4405                 4410             


Ser Ala  Asp Pro Asn Ala Ile  Asp Thr Asp Tyr Tyr  Pro Gly Gly 
    4415                 4420                 4425             


Tyr Asp  Ile Glu Ser Asp Phe  Pro Pro Pro Pro Glu  Asp Phe Pro 
    4430                 4435                 4440             


Ala Ala  Asp Glu Leu Pro Pro  Leu Pro Pro Glu Phe  Ser Asn Gln 
    4445                 4450                 4455             


Phe Glu  Ser Ile His Pro Pro  Arg Asp Met Pro Ala  Ala Gly Ser 
    4460                 4465                 4470             


Leu Gly  Ser Ser Ser Arg Asn  Arg Gln Arg Phe Asn  Leu Asn Gln 
    4475                 4480                 4485             


Tyr Leu  Pro Asn Phe Tyr Pro  Leu Asp Met Ser Glu  Pro Gln Thr 
    4490                 4495                 4500             


Lys Gly  Thr Gly Glu Asn Ser  Thr Cys Arg Glu Pro  His Ala Pro 
    4505                 4510                 4515             


Tyr Pro  Pro Gly Tyr Gln Arg  His Phe Glu Ala Pro  Ala Val Glu 
    4520                 4525                 4530             


Ser Met  Pro Met Ser Val Tyr  Ala Ser Thr Ala Ser  Cys Ser Asp 
    4535                 4540                 4545             


Val Ser  Ala Cys Cys Glu Val  Glu Ser Glu Val Met  Met Ser Asp 
    4550                 4555                 4560             


Tyr Glu  Ser Gly Asp Asp Gly  His Phe Glu Glu Val  Thr Ile Pro 
    4565                 4570                 4575             


Pro Leu  Asp Ser Gln Gln His  Thr Glu Val 
    4580                 4585             


<210>  971
<211>  1065
<212>  DNA
<213>  Homosapiens

<400>  971
atgacgtctg tatcacttct gctcgaaagt gtccagctgc ccattccctc tgagatgacg     60

tctgtatccc tcctgctcga aagcatccag ctgcccattc cctctgaagt gacgtctgta    120

tcactcctgc tcgaaagcgt ccagctgccc attccctcta aagtgacgtc tgtatcactc    180

ctgctcgaaa gtgtccagct gcccattccc tctaaagtga cgtctgtatc acttctgctc    240

gaaagtgtcc agctgcccat tccctctaaa gtgacgtctg tatcactcct gctcgaaagc    300

gtccagctgc ccattccctc taaagtgacg tctgtatccc tcctgctcga aagtgtccag    360

ctgcccattc cctctaaagt gacgtctgta tcactcctgc tcgaaagtgt ccagctgccc    420

attccctcta aagtgacgtc tgtatcactt ctgctcgaaa gtgtccagct gcccattccc    480

tctgaagtga cgtctgtatc actcctgctc gaaagtgtcc agctgcccat tccctctgaa    540

gtgacgtctg tatcactcct gctcgaaagt gtccagctgc ccattccctc tgaaatgacg    600

tctgtatcac tcctgctcga aagtgtccag ctgcccattc cctctaaagt gacgtctgta    660

tcacttctgc tcgaaagtgt ccagctgccc attccctcta aagtgacgtc tgtatcactt    720

ctgctcgaaa gtgtccagct gcccattccc tctgaagtga cgtctgtatc actcctgctc    780

gaaagtgtcc agctgcccat tccctctgaa gtgacgtctg tatcacttct gctcgaaagt    840

gtccagctgc ccgttccctc taaagtgacg tctgtatcac ttctgctcga aagtgtccag    900

ctgcccgttc cctctgaaat gacatctgta tcacttctgc tcgaaagtgt ccagctgccc    960

gttccctctg aaatgacgtc tgtatcactc ctgctcgaaa gcatccagct gcccattccc   1020

tctgaaatga catctccatc actcctgctt gaaagctctc tctga                   1065


<210>  972
<211>  354
<212>  PRT
<213>  Homosapiens

<400>  972

Met Thr Ser Val Ser Leu Leu Leu Glu Ser Val Gln Leu Pro Ile Pro 
1               5                   10                  15      


Ser Glu Met Thr Ser Val Ser Leu Leu Leu Glu Ser Ile Gln Leu Pro 
            20                  25                  30          


Ile Pro Ser Glu Val Thr Ser Val Ser Leu Leu Leu Glu Ser Val Gln 
        35                  40                  45              


Leu Pro Ile Pro Ser Lys Val Thr Ser Val Ser Leu Leu Leu Glu Ser 
    50                  55                  60                  


Val Gln Leu Pro Ile Pro Ser Lys Val Thr Ser Val Ser Leu Leu Leu 
65                  70                  75                  80  


Glu Ser Val Gln Leu Pro Ile Pro Ser Lys Val Thr Ser Val Ser Leu 
                85                  90                  95      


Leu Leu Glu Ser Val Gln Leu Pro Ile Pro Ser Lys Val Thr Ser Val 
            100                 105                 110         


Ser Leu Leu Leu Glu Ser Val Gln Leu Pro Ile Pro Ser Lys Val Thr 
        115                 120                 125             


Ser Val Ser Leu Leu Leu Glu Ser Val Gln Leu Pro Ile Pro Ser Lys 
    130                 135                 140                 


Val Thr Ser Val Ser Leu Leu Leu Glu Ser Val Gln Leu Pro Ile Pro 
145                 150                 155                 160 


Ser Glu Val Thr Ser Val Ser Leu Leu Leu Glu Ser Val Gln Leu Pro 
                165                 170                 175     


Ile Pro Ser Glu Val Thr Ser Val Ser Leu Leu Leu Glu Ser Val Gln 
            180                 185                 190         


Leu Pro Ile Pro Ser Glu Met Thr Ser Val Ser Leu Leu Leu Glu Ser 
        195                 200                 205             


Val Gln Leu Pro Ile Pro Ser Lys Val Thr Ser Val Ser Leu Leu Leu 
    210                 215                 220                 


Glu Ser Val Gln Leu Pro Ile Pro Ser Lys Val Thr Ser Val Ser Leu 
225                 230                 235                 240 


Leu Leu Glu Ser Val Gln Leu Pro Ile Pro Ser Glu Val Thr Ser Val 
                245                 250                 255     


Ser Leu Leu Leu Glu Ser Val Gln Leu Pro Ile Pro Ser Glu Val Thr 
            260                 265                 270         


Ser Val Ser Leu Leu Leu Glu Ser Val Gln Leu Pro Val Pro Ser Lys 
        275                 280                 285             


Val Thr Ser Val Ser Leu Leu Leu Glu Ser Val Gln Leu Pro Val Pro 
    290                 295                 300                 


Ser Glu Met Thr Ser Val Ser Leu Leu Leu Glu Ser Val Gln Leu Pro 
305                 310                 315                 320 


Val Pro Ser Glu Met Thr Ser Val Ser Leu Leu Leu Glu Ser Ile Gln 
                325                 330                 335     


Leu Pro Ile Pro Ser Glu Met Thr Ser Pro Ser Leu Leu Leu Glu Ser 
            340                 345                 350         


Ser Leu 
        


<210>  973
<211>  1030
<212>  DNA
<213>  Homosapiens

<400>  973
tgcagagtgt ggagcgtgga gcgccgggac tgtgcacgct tgaccggaag cccagaccag     60

tgcggtccta gccagagaga aaggacattt gccaacaatg agacacgaag cgcccatgca    120

gatggcctct gcccaagatg ccaggtacgg ccagaaagac tcctctgatc agaactttga    180

ctacatgttc aaattactca tcatcggcaa tagcagtgtg gggaaaacat cttttctatt    240

ccgttatgca gatgactcct ttacatctgc attcgtcagc acagttggga tcgatttcaa    300

agtaaaaact gtattcaaaa atgaaaagag aatcaagctt cagatttggg acacagcagg    360

ccaggaaaga tacaggacta tcaccacagc ctattatcgt ggagccatgg gctttatttt    420

aatgtatgac attacaaatg aagaatcctt caatgcagta caagattggt caactcaaat    480

caaaacatac tcttgggaca atgcccaagt tattctggtt gggaacaagt gtgacatgga    540

agacgagcgg gtcatctcaa ctgagcgagg tcaacattta ggagaacagc ttgggtttga    600

gttttttgaa acaagtgcca aggacaacat taatgtcaag cagacatttg agcgccttgt    660

ggatatcatc tgcgacaaaa tgtcagagag tttggagact gatcctgcca tcactgctgc    720

aaagcagaac acgagactca aggaaactcc tcctccaccg cagcccaact gtgcctgcta    780

gtgtccccgt gcacacaggc agctccaggg ggctctggtt gccaacaaac agcatttgta    840

aatggtctat tagccttcat ttatactgcc taacaattat ttgaaggaat aaattgatgt    900

caatggctcg tacgcattca attcttggga gctttcctgt ttaatatgtg gcaaatatgt    960

gatcttaaat ttataaggac tatccatcta taaacatctg gtacctgcaa aaaaaaaaaa   1020

aaaaaaaaaa                                                          1030


<210>  974
<211>  227
<212>  PRT
<213>  Homosapiens

<400>  974

Met Arg His Glu Ala Pro Met Gln Met Ala Ser Ala Gln Asp Ala Arg 
1               5                   10                  15      


Tyr Gly Gln Lys Asp Ser Ser Asp Gln Asn Phe Asp Tyr Met Phe Lys 
            20                  25                  30          


Leu Leu Ile Ile Gly Asn Ser Ser Val Gly Lys Thr Ser Phe Leu Phe 
        35                  40                  45              


Arg Tyr Ala Asp Asp Ser Phe Thr Ser Ala Phe Val Ser Thr Val Gly 
    50                  55                  60                  


Ile Asp Phe Lys Val Lys Thr Val Phe Lys Asn Glu Lys Arg Ile Lys 
65                  70                  75                  80  


Leu Gln Ile Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Thr Ile Thr 
                85                  90                  95      


Thr Ala Tyr Tyr Arg Gly Ala Met Gly Phe Ile Leu Met Tyr Asp Ile 
            100                 105                 110         


Thr Asn Glu Glu Ser Phe Asn Ala Val Gln Asp Trp Ser Thr Gln Ile 
        115                 120                 125             


Lys Thr Tyr Ser Trp Asp Asn Ala Gln Val Ile Leu Val Gly Asn Lys 
    130                 135                 140                 


Cys Asp Met Glu Asp Glu Arg Val Ile Ser Thr Glu Arg Gly Gln His 
145                 150                 155                 160 


Leu Gly Glu Gln Leu Gly Phe Glu Phe Phe Glu Thr Ser Ala Lys Asp 
                165                 170                 175     


Asn Ile Asn Val Lys Gln Thr Phe Glu Arg Leu Val Asp Ile Ile Cys 
            180                 185                 190         


Asp Lys Met Ser Glu Ser Leu Glu Thr Asp Pro Ala Ile Thr Ala Ala 
        195                 200                 205             


Lys Gln Asn Thr Arg Leu Lys Glu Thr Pro Pro Pro Pro Gln Pro Asn 
    210                 215                 220                 


Cys Ala Cys 
225         


<210>  975
<211>  5876
<212>  DNA
<213>  Homosapiens

<400>  975
ggaattcatc tgtaaaaatc actacatgta acgtaggaga caagaaaaat attaatgaca     60

gaagatctgc gaacatgatg cacgtgaata attttccctt tagaaggcat tcctggatat    120

gttttgatgt ggacaatggc acatctgcgg gacggagtcc cttggatccc atgaccagcc    180

caggatccgg gctaattctc caagcaaatt ttgtccacag tcaacgacgg gagtccttcc    240

tgtatcgatc cgacagcgat tatgacctct ctccaaagtc tatgtcccgg aactcctcca    300

ttgccagtga tatacacgga gatgacttga ttgtgactcc atttgctcag gtcttggcca    360

gtctgcgaac tgtacgaaac aactttgctg cattaactaa tttgcaagat cgagcaccta    420

gcaaaagatc acccatgtgc aaccaaccat ccatcaacaa agccaccata acagaggagg    480

cctaccagaa actggccagc gagaccctgg aggagctgga ctggtgtctg gaccagctag    540

agaccctaca gaccaggcac tccgtcagtg agatggcctc caacaagttt aaaaggatgc    600

ttaatcggga gctcacccat ctctctgaaa tgagtcggtc tggaaatcaa gtgtcagagt    660

ttatatcaaa cacattctta gataagcaac atgaagtgga aattccttct ccaactcaga    720

aggaaaagga gaaaaagaaa agaccaatgt ctcagatcag tggagtcaag aaattgatgc    780

acagctctag tctgactaat tcaagtatcc caaggtttgg agttaaaact gaacaagaag    840

atgtccttgc caaggaacta gaagatgtga acaaatgggg tcttcatgtt ttcagaatag    900

cagagttgtc tggtaaccgg cccttgactg ttatcatgca caccattttt caggaacggg    960

atttattaaa aacatttaaa attccagtag atactttaat tacatatctt atgactctcg   1020

aagaccatta ccatgctgat gtggcctatc acaacaatat ccatgctgca gatgttgtcc   1080

agtctactca tgtgctatta tctacacctg ctttggaggc tgtgtttaca gatttggaga   1140

ttcttgcagc aatttttgcc agtgcaatac atgatgtaga tcatcctggt gtgtccaatc   1200

aatttctgat caatacaaac tctgaacttg ccttgatgta caatgattcc tcagtcttag   1260

agaaccatca tttggctgtg ggctttaaat tgcttcagga agaaaactgt gacattttcc   1320

agaatttgac caaaaaacaa agacaatctt taaggaaaat ggtcattgac atcgtacttg   1380

caacagatat gtcaaaacac atgaatctac tggctgattt gaagactatg gttgaaacta   1440

agaaagtgac aagctctgga gttcttcttc ttgataatta ttccgatagg attcaggttc   1500

ttcagaatat ggtgcactgt gcagatctga gcaacccaac aaagcctctc cagctgtacc   1560

gccagtggac ggaccggata atggaggagt tcttccgcca aggagaccga gagagggaac   1620

gtggcatgga gataagcccc atgtgtgaca agcacaatgc ttccgtggaa aaatcacagg   1680

tgggcttcat agactatatt gttcatcccc tctgggagac atgggcagac ctcgtccacc   1740

ctgacgccca ggatattttg gacactttgg aggacaatcg tgaatggtac cagagcacaa   1800

tccctcagag cccctctcct gcacctgatg acccagagga gggccggcag ggtcaaactg   1860

agaaattcca gtttgaacta actttagagg aagatggtga gtcagacacg gaaaaggaca   1920

gtggcagtca agtggaagaa gacactagct gcagtgactc caagactctt tgtactcaag   1980

actcagagtc tactgaaatt ccccttgatg aacaggttga agaggaggca gtaggggaag   2040

aagaggaaag ccagcctgaa gcctgtgtca tagatgatcg ttctcctgac acgtaacagt   2100

gcaaaaactt tcatgccttt ttttttttta agtagaaaaa ttgtttccaa agtgcatgtc   2160

acatgccaca accacggtca cacctcactg tcatctgcca ggacgtttgt tgaacaaaac   2220

tgaccttgac tactcagtcc agcgctcagg aatatcgtaa ccagtttttt cacctccatg   2280

tcatccgagc aaggtggaca tcttcacgaa cagcgttttt aacaagattt cagcttggta   2340

gagctgacaa agcagataaa atctactcca aattattttc aagagagtgt gactcatcag   2400

gcagcccaaa agtttattgg acttggggtt tctattcctt tttatttgtt tgcaatattt   2460

tcagaagaaa ggcattgcac agagtgaact taatggacga agcaacaaat atgtcaagaa   2520

caggacatag cacgaatctg ttaccagtag gaggaggatg agccacagaa attgcataat   2580

tttctaattt caagtcttcc tgatacatga ctgaatagtg tggttcagtg agctgcactg   2640

acctctacat tttgtatgat atgtaaaaca gattttttgt agagcttact tttattatta   2700

aatgtattga ggtattatat ttaaaaaaaa ctatgttcag aacttcatct gccactggtt   2760

atttttttct aaggagtaac ttgcaagttt tcagtacaaa tctgtgctac actggataaa   2820

aatctaattt atgaatttta cttgcacctt atagttcata gcaattaact gatttgtagt   2880

gattcattgt ttgttttata taccaatgac ttccatattt taaaagagaa aaacaacttt   2940

atgttgcagg aaaccctttt tgtaagtctt tattatttac tttgcatttt gtttcactct   3000

ttccagataa gcagagttgc tcttcaccag tgtttttctt catgtgcaaa gtgactattt   3060

gttctataat acttttatgt gtgttatatc aaatgtgtct taagcttcat gcaaactcag   3120

tcatcagttc gtgttgtctg aagcaagtgg gaaatatata aatacccagt agctaaaatg   3180

gtcagtcttt tttagatgtt ttcctactta gtatctccta ataacgtttt gctgtgtcac   3240

tagatgttca tttcacaagt gcatgtcttt ctaataatcc acacatttca tgctctaata   3300

atccacacat ttcatgctca tttttattgt ttttacagcc agttatagca agaaaaaggt   3360

ttttcccctt gtgctgcttt ataatttagc gtgtgtctga accttatcca tgtttgctag   3420

atgaggtctt gtcaaatata tcactaccat tgtcaccggt gaaaagaaac aggtagttaa   3480

gttagggtta acattcattt caaccacgag gttgtatatc atgactagct tttactcttg   3540

gtttacagag aaaagttaaa caaccaacta ggcagttttt aagaatatta acaatatatt   3600

aacaaacacc aatacaacta atcctatttg gttttaatga tttcaccatg ggattaagaa   3660

ctatatcagg aacatccctg agaaacggct ttaagtgtag caactactct tccttaatgg   3720

acagccacat aacgtgtagg aagtccttta tcacttatcc tcgatccata agcatatctt   3780

gcagagggga actacttctt taaacacatg gagggaaaga agatgatgcc actggcacca   3840

gagggttagt actgtgatgc atcctaaaat atttattata ttggtaaaaa ttctggttaa   3900

ataaaaaatt agagatcact cttggctgat ttcagcacca ggaactgtat tacagtttta   3960

gagattaatt cctagtgttt acctgattat agcagttggc atcatggggc atttaattct   4020

gactttatcc ccacgtcagc cttaataaag tcttctttac cttctctatg aagactttaa   4080

agcccaaata atcatttttc acattgatat tcaagaattg agatagatag aagccaaagt   4140

gggtatctga caagtggaaa atcaaacgtt taagaagaat tacaactctg aaaagcattt   4200

atatgtggaa cttctcaagg agcctcctgg ggactggaaa gtaagtcatc agccaggcaa   4260

atgactcatg ctgaagagag tccccatttc agtcccctga gatctagctg atgcttagat   4320

cctttgaaat aaaaattatg tctttataac tctgatcttt tacataaagc agaagaggaa   4380

tcaactagtt aattgcaagg tttctactct gtttcctctg taaagatcag atggtaatct   4440

ttcaaataag aaaaaaataa agacgtatgt ttgaccaagt agtttcacaa gaatatttgg   4500

gaacttgttt cttttaattt tatttgtccc tgagtgaagt ctagaaagaa aggtaaagag   4560

tctagagttt attcctcttt ccaaaacatt ctcattcctc tcctccctac acttagtatt   4620

tcccccacag agtgcctaga atcttaataa tgaataaaat aaaaagcagc aatatgtcat   4680

taacaaatcc agacctgaaa gggtaaaggg tttataactg cactaataaa gagaggctct   4740

ttttttttct tccagtttgt tggtttttaa tggtaccgtg ttgtaaagat acccactaat   4800

ggacaatcaa attgcagaaa aggctcaata tccaagagac agggactaat gcactgtaca   4860

atctgcttat ccttgccctt ctctcttgcc aaagtgtgct tcagaaatat atactgcttt   4920

aaaaaagaat aaaagaatat ccttttacaa gtggctttac atttcctaaa atgccataag   4980

aaaatgcaat atctgggtac tgtatgggga aaaaaatgtc caagtttgtg taaaaccagt   5040

gcatttcagc ttgcaagtta ctgaacacaa taatgctgtt ttaattttgt tttatatcag   5100

ttaaaattca caataatgta gatagaacaa attacagaca aggaaagaaa aaacttgaat   5160

gaaatggatt ttacagaaag ctttatgata atttttgaat gcattattta ttttttgtgc   5220

catgcatttt ttttctcacc aaatgacctt acctgtaata cagtcttgtt tgtctgttta   5280

caaccatgta tttattgcaa tgtacatact gtaatgttaa ttgtaaatta tctgttctta   5340

ttaaaacatc atcccatgat ggggtggtgt tgatatattt ggaaactctt ggtgagagaa   5400

tgaatggtgt gtatacatac tctgtacatt tttcttttct cctgtaatat agtcttgtca   5460

ccttagagct tgtttatgga agattcaaga aaactataaa atacttaaag atatataaat   5520

ttaaaaaaac atagctgcag gtctttggtc ccagggctgt gccttaactt taaccaatat   5580

tttcttctgt tttgctgcat ttgaaaggta acagtggagc tagggctggg cattttacat   5640

ccaggctttt aattgattag aattctgcca ataggtggat tttacaaaac cacagacaac   5700

ctctgaaaga ttctgagacc cttttgagac agaagctctt aagtacttct tgccagggag   5760

cagcactgca tgtgtgatgg ttgtttgcca tctgttgatc aggaactact tcagctactt   5820

gcatttgatt atttcctttt tttttttttt taactcggaa acacaactgg gggaat       5876


<210>  976
<211>  673
<212>  PRT
<213>  Homosapiens

<400>  976

Met Met His Val Asn Asn Phe Pro Phe Arg Arg His Ser Trp Ile Cys 
1               5                   10                  15      


Phe Asp Val Asp Asn Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro 
            20                  25                  30          


Met Thr Ser Pro Gly Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His 
        35                  40                  45              


Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp 
    50                  55                  60                  


Leu Ser Pro Lys Ser Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile 
65                  70                  75                  80  


His Gly Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser 
                85                  90                  95      


Leu Arg Thr Val Arg Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp 
            100                 105                 110         


Arg Ala Pro Ser Lys Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn 
        115                 120                 125             


Lys Ala Thr Ile Thr Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr 
    130                 135                 140                 


Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr 
145                 150                 155                 160 


Arg His Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu 
                165                 170                 175     


Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln 
            180                 185                 190         


Val Ser Glu Phe Ile Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val 
        195                 200                 205             


Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro 
    210                 215                 220                 


Met Ser Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu 
225                 230                 235                 240 


Thr Asn Ser Ser Ile Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp 
                245                 250                 255     


Val Leu Ala Lys Glu Leu Glu Asp Val Asn Lys Trp Gly Leu His Val 
            260                 265                 270         


Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met 
        275                 280                 285             


His Thr Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro 
    290                 295                 300                 


Val Asp Thr Leu Ile Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His 
305                 310                 315                 320 


Ala Asp Val Ala Tyr His Asn Asn Ile His Ala Ala Asp Val Val Gln 
                325                 330                 335     


Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr 
            340                 345                 350         


Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val 
        355                 360                 365             


Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu 
    370                 375                 380                 


Leu Ala Leu Met Tyr Asn Asp Ser Ser Val Leu Glu Asn His His Leu 
385                 390                 395                 400 


Ala Val Gly Phe Lys Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln 
                405                 410                 415     


Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp 
            420                 425                 430         


Ile Val Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp 
        435                 440                 445             


Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu 
    450                 455                 460                 


Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val 
465                 470                 475                 480 


His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg 
                485                 490                 495     


Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg 
            500                 505                 510         


Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Asn 
        515                 520                 525             


Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His 
    530                 535                 540                 


Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp 
545                 550                 555                 560 


Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile 
                565                 570                 575     


Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln 
            580                 585                 590         


Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly 
        595                 600                 605             


Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr 
    610                 615                 620                 


Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr 
625                 630                 635                 640 


Glu Ile Pro Leu Asp Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu 
                645                 650                 655     


Glu Glu Ser Gln Pro Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp 
            660                 665                 670         


Thr 
    


<210>  977
<211>  3624
<212>  DNA
<213>  Homosapiens

<400>  977
cagacagccc attttttctt atgataaaga cggcatttgg ctcatgagca aggtggcaag     60

atcatcaagt gagtcagacg tgcagctctg ggaaacagaa gaggatgaca tgacagaagg    120

tgatttaggg tatggcctcg gaaggaaacc tggtgggatt tatgaaatag aattttcaca    180

taggtctaga aaaagatcag atggaaagaa ctttagccct cctccatttc cgagaaaggg    240

agaagaaaga aatgaagcga gttttcagta ttccaagcat aagagccagc aagatacatt    300

ccctcaagtg tccagaattt ccaattacag acgacaaagt agcactgtag attcgaattc    360

agaattgtca aatgaagaat taaggcaatg tcttaatgaa actttagagg aggtagaaat    420

gttaaaaact gaacttgagg catctcaaag acaactcaga ggtaaagagg aagcattgaa    480

aattcttcaa agcatggcaa tactgggcaa agccacaagt catacgcagg cagtgcttca    540

aaaaactatg gaacaaaaca gatccttgga gaaggaaata aatgccttgc agtgggaaat    600

agaatttgat cataatagat ttaaaaatat agaggaatct tggatccaaa aatatgacag    660

gctaaactgt gaaaatgcag tcctcaaaga gaatttgaaa gtgaaaacag aagaaattaa    720

aatgctgaag tctgacaatg cagttttgaa tcaacggtat ttggaggccc tcgccatgct    780

tgatatcaaa cagcagaaga tggctcagga aaacatgtgc tgtgataaaa gtggctttgc    840

agaggcttca ggtcttgagc ttgcggtcct cggagcctgc ctttgtcatg ggcccggagg    900

gaacccctgt tcttgtgcca gaatggcagc atccactcgg aaactgcttc ttcagctcaa    960

acaagagttg gaaattttgc agaagagtaa agaagaagct tacgtgatgg cagatgcttt   1020

cagaattgca tttgagcaac aattaatgag aaaaaatgac caggcactac aattgacaca   1080

aatggataaa atgcataaaa aagcaacaaa atggatgaat tggaagcacc ttaaagagga   1140

tggatttcca tcaccaagga gtaagaagac cttcgggcag agactgttgg gtatgctccc   1200

ttcagaaaac agttctaaga ggatggaaga ccaggacagt cctcaagagg tccttaagat   1260

gctcatagat ttgcttaatg ataaagaaga agctttggct catcaaagaa aagttagcta   1320

catgcttgct cgggcattgg aagacaaaga cactgcttca aacgagaata aagaaaaaaa   1380

tcctataaaa gagaatttcc ctttcaacaa cccctggcgt aagacttcag aattctctgt   1440

tttgggtgat cctatacatt caagtgtctg cattttaaat tctgtgggct gcatttgttc   1500

aatccagcac tctcaaatag atccaaacta tagaactctt aaaagatccc attctttgcc   1560

atcaagtatc atattttaaa gacaagccag ttgaaattgg aactgagagt tgtttatatc   1620

gagatacttt gaaaaatgat tttgtaaatt ttgctgcatc ttgagaagtt gtatgtttcc   1680

taggtatttc taaattttag gaggtcactt aaatcaaata ttttctacat tttctttttc   1740

ttcttttgag atggagtctt gctctgtcac ccaggttgga gtgcagtggt gtgatctcgg   1800

ttcactgcaa cctccgcctc ccggttcaag caattctcct gcctcagcct cccgagtaac   1860

tcggattaca ggcatgtgcc accacgccca gctaattttt gtatttttag tagagacggg   1920

gttttaccat gttagccagg ctgatcttga actcctgacc tcaagtgatc cgcctgcctt   1980

ggcctccgaa agtgctggga ttacaggcgt gagccaccac acccagccta ttttctacat   2040

tttctacaag aaattagtat tctgtgttga cattttattt ataaattaca ttactgtatt   2100

tataaattac attacaggct gggcatggtg gctcatgctt ataaatccca gcactttggg   2160

aggccaaggt gggtgggtca cctgaggctg gagttcaaga ccagtctgac caacatggag   2220

aaaccccatc tctactaaaa atacaaaaaa ttagctaggc ctagtggcgc atgcctgtaa   2280

tcccagctac ttgggaggct gaggtaggag aatcgcttga acctgggagg cgggggttgt   2340

ggtaagccga gactgtgtca ttgcactcca gcctgggcga caagagcgaa actctgtctc   2400

aaaaaaaaaa aaaaacacat tacagtgttt gccaacatcc taaaacaaaa aataatgatt   2460

tttgggaaaa acaaaaaatt atttaactat tttgattgac tatagggatc ttagcttggc   2520

taaatcaaca atatagcaat gtatcttaat gctctaaaaa gtaacaatac ctaggactga   2580

ctgaatgtta atttctggaa ttcatttatc ttgttttatt tgccttgttc agtatttttc   2640

atttaccata tgaagtttag aaataacaat ttccttaagt taacttcaat aagacagttt   2700

tgatggtggg accttggcag aagtatattg agtcagtgcc ggctgcgttc atggcttctt   2760

gtcagggtag taacattttg caaccaaatc tgcacagatt tgtagccaag tctacaaagt   2820

gcttaacagc tcttttcatt gcatcctgtg agatggttgt gatgatccag gaaatggggt   2880

ctcaggaatc tgaagaagct gcctgagcca aggtgatttc taggagtttt tttgtttgtg   2940

gtatgtgaat tggggtgtgt gggggtgggg tgtgtgtgta gacagggtcc cactgtgttg   3000

ctcaggctgg tgccaaactc ctggcctcaa gggatcctcc tgcctcagcc tctcaaagtg   3060

ctgggattac aggcataaac cacaactcaa taaaaaagtt tttaaaaatt tacaaagctc   3120

atatttgatc cagctaggat tttaccctgt acatttgtat ttcttgtagg ctggcgcaca   3180

gatatcttaa atggctacta attgctgctg tgtatgaaaa caaatggcta tcaaggccgg   3240

gtgcagtggc ttacagatct ggtctgaatc tcaagtccag accagtccag agttcaagac   3300

cagcctgggc aacatggtga aaccccatct atacaaaaac tcggcaaggc atggtggcat   3360

gcacctgttg tcccagctac tcaggggctg aggcaggagg atggcatgag cccaggagct   3420

tgaggctgca gtgagctgtg attgtgccac tgcactccag cctgagtgac agagtgagac   3480

ccccatctcc aaaagaaaag gctatcaata caaaagttta tctaaattac tgtacagcta   3540

tacaatggaa tactctacaa aatggagaga tccataagat aaagcaaatg aataaagcaa   3600

aatgcatgtg ttgacaaaaa aaaa                                          3624


<210>  978
<211>  511
<212>  PRT
<213>  Homosapiens

<400>  978

Met Ser Lys Val Ala Arg Ser Ser Ser Glu Ser Asp Val Gln Leu Trp 
1               5                   10                  15      


Glu Thr Glu Glu Asp Asp Met Thr Glu Gly Asp Leu Gly Tyr Gly Leu 
            20                  25                  30          


Gly Arg Lys Pro Gly Gly Ile Tyr Glu Ile Glu Phe Ser His Arg Ser 
        35                  40                  45              


Arg Lys Arg Ser Asp Gly Lys Asn Phe Ser Pro Pro Pro Phe Pro Arg 
    50                  55                  60                  


Lys Gly Glu Glu Arg Asn Glu Ala Ser Phe Gln Tyr Ser Lys His Lys 
65                  70                  75                  80  


Ser Gln Gln Asp Thr Phe Pro Gln Val Ser Arg Ile Ser Asn Tyr Arg 
                85                  90                  95      


Arg Gln Ser Ser Thr Val Asp Ser Asn Ser Glu Leu Ser Asn Glu Glu 
            100                 105                 110         


Leu Arg Gln Cys Leu Asn Glu Thr Leu Glu Glu Val Glu Met Leu Lys 
        115                 120                 125             


Thr Glu Leu Glu Ala Ser Gln Arg Gln Leu Arg Gly Lys Glu Glu Ala 
    130                 135                 140                 


Leu Lys Ile Leu Gln Ser Met Ala Ile Leu Gly Lys Ala Thr Ser His 
145                 150                 155                 160 


Thr Gln Ala Val Leu Gln Lys Thr Met Glu Gln Asn Arg Ser Leu Glu 
                165                 170                 175     


Lys Glu Ile Asn Ala Leu Gln Trp Glu Ile Glu Phe Asp His Asn Arg 
            180                 185                 190         


Phe Lys Asn Ile Glu Glu Ser Trp Ile Gln Lys Tyr Asp Arg Leu Asn 
        195                 200                 205             


Cys Glu Asn Ala Val Leu Lys Glu Asn Leu Lys Val Lys Thr Glu Glu 
    210                 215                 220                 


Ile Lys Met Leu Lys Ser Asp Asn Ala Val Leu Asn Gln Arg Tyr Leu 
225                 230                 235                 240 


Glu Ala Leu Ala Met Leu Asp Ile Lys Gln Gln Lys Met Ala Gln Glu 
                245                 250                 255     


Asn Met Cys Cys Asp Lys Ser Gly Phe Ala Glu Ala Ser Gly Leu Glu 
            260                 265                 270         


Leu Ala Val Leu Gly Ala Cys Leu Cys His Gly Pro Gly Gly Asn Pro 
        275                 280                 285             


Cys Ser Cys Ala Arg Met Ala Ala Ser Thr Arg Lys Leu Leu Leu Gln 
    290                 295                 300                 


Leu Lys Gln Glu Leu Glu Ile Leu Gln Lys Ser Lys Glu Glu Ala Tyr 
305                 310                 315                 320 


Val Met Ala Asp Ala Phe Arg Ile Ala Phe Glu Gln Gln Leu Met Arg 
                325                 330                 335     


Lys Asn Asp Gln Ala Leu Gln Leu Thr Gln Met Asp Lys Met His Lys 
            340                 345                 350         


Lys Ala Thr Lys Trp Met Asn Trp Lys His Leu Lys Glu Asp Gly Phe 
        355                 360                 365             


Pro Ser Pro Arg Ser Lys Lys Thr Phe Gly Gln Arg Leu Leu Gly Met 
    370                 375                 380                 


Leu Pro Ser Glu Asn Ser Ser Lys Arg Met Glu Asp Gln Asp Ser Pro 
385                 390                 395                 400 


Gln Glu Val Leu Lys Met Leu Ile Asp Leu Leu Asn Asp Lys Glu Glu 
                405                 410                 415     


Ala Leu Ala His Gln Arg Lys Val Ser Tyr Met Leu Ala Arg Ala Leu 
            420                 425                 430         


Glu Asp Lys Asp Thr Ala Ser Asn Glu Asn Lys Glu Lys Asn Pro Ile 
        435                 440                 445             


Lys Glu Asn Phe Pro Phe Asn Asn Pro Trp Arg Lys Thr Ser Glu Phe 
    450                 455                 460                 


Ser Val Leu Gly Asp Pro Ile His Ser Ser Val Cys Ile Leu Asn Ser 
465                 470                 475                 480 


Val Gly Cys Ile Cys Ser Ile Gln His Ser Gln Ile Asp Pro Asn Tyr 
                485                 490                 495     


Arg Thr Leu Lys Arg Ser His Ser Leu Pro Ser Ser Ile Ile Phe 
            500                 505                 510     


<210>  979
<211>  1199
<212>  DNA
<213>  Homosapiens

<400>  979
cccaggaaag cttgaaggca gagatagact cacgtctcta agacatatac ataatatagc     60

cgcaaccgcg gcggccttac tttcccggag ctgcatcccc ttttaggcga agagcggagg    120

cgaccaggga ctaccctagg tgaaagggca gccacctggc cctacccggg ctcaacgccg    180

agcctctcgg aggtacggcc tcccggggac cttccagact ggtcggcgca agcgaagggc    240

ggggaccacc gaaggagtgt gtgacttagg catccagcgc actgcctgac ccgaagtacc    300

gacccgagtt atgcccaccc tccaactttg cgacggaaat gtgtcatcga aagccaggta    360

caccaggggt tggaaaaacc acactaggca aagaacttgc gtcaaaatca ggactgaaat    420

acattaatgt gggtgattta gctcgagaag agcaattgta tgatggctat gatgaagagt    480

atgactgtcc cattttagat gaagacagag tagttgatga gttagataac caaatgagag    540

aaggtggagt tattgttgat taccatggtt gtgatttctt ccctgaacgc tggtttcata    600

tagtttttgt gctgagaaca gataccaatg tattgtacga aagacttgaa acaaggggtt    660

ataatgagaa gaaactaaca gacaatattc agtgtgagat ttttcaagtt ctttatgaag    720

aagccacagc atcctacaag gaagaaatcg tgcatcagct gcccagtaat aaaccagaag    780

agctagaaaa taatgtagat cagatcttga aatggattga gcagtggatc aaagatcata    840

actcttgact tataaggcta gctacttaat aatcactctt gttgatatct ctgccgacat    900

catagaaatt gttcaagtgt cagtaacact ttattaaaat catgttgcag aaccagcagg    960

tggatagtat ataggtttat gcctgtgttt ctttttctcc atgagaaagc taaacatgaa   1020

atataatgaa tatagtatta ttaaggattg agacaaaaac tgtgatttta atacttaaat   1080

tgctaaagaa taaataaatc tgacaaaatg ggtggatatc ttttaagttt attacagaaa   1140

aaaatgcaga tgatctctta aaataaaact aaagataaag caaaaaaaaa aaaaaaaaa    1199


<210>  980
<211>  169
<212>  PRT
<213>  Homosapiens

<400>  980

Met Cys His Arg Lys Pro Gly Thr Pro Gly Val Gly Lys Thr Thr Leu 
1               5                   10                  15      


Gly Lys Glu Leu Ala Ser Lys Ser Gly Leu Lys Tyr Ile Asn Val Gly 
            20                  25                  30          


Asp Leu Ala Arg Glu Glu Gln Leu Tyr Asp Gly Tyr Asp Glu Glu Tyr 
        35                  40                  45              


Asp Cys Pro Ile Leu Asp Glu Asp Arg Val Val Asp Glu Leu Asp Asn 
    50                  55                  60                  


Gln Met Arg Glu Gly Gly Val Ile Val Asp Tyr His Gly Cys Asp Phe 
65                  70                  75                  80  


Phe Pro Glu Arg Trp Phe His Ile Val Phe Val Leu Arg Thr Asp Thr 
                85                  90                  95      


Asn Val Leu Tyr Glu Arg Leu Glu Thr Arg Gly Tyr Asn Glu Lys Lys 
            100                 105                 110         


Leu Thr Asp Asn Ile Gln Cys Glu Ile Phe Gln Val Leu Tyr Glu Glu 
        115                 120                 125             


Ala Thr Ala Ser Tyr Lys Glu Glu Ile Val His Gln Leu Pro Ser Asn 
    130                 135                 140                 


Lys Pro Glu Glu Leu Glu Asn Asn Val Asp Gln Ile Leu Lys Trp Ile 
145                 150                 155                 160 


Glu Gln Trp Ile Lys Asp His Asn Ser 
                165                 


<210>  981
<211>  1482
<212>  DNA
<213>  Homosapiens

<400>  981
cccaggaaag cttgaaggca gagatagact cacgtctcta agacatatac ataatatagc     60

cgcaaccgcg gcggccttac tttcccggag ctgcatcccc ttttaggcga agagcggagg    120

cgaccaggga ctaccctagg tgaaagggca gccacctggc cctacccggg ctcaacgccg    180

agcctctcgg aggtacggcc tcccggggac cttccagact ggtcggcgca agcgaagggc    240

ggggaccacc gaaggagtgt gtgacttagg catccagcgc actgcctgac ccgaagtacc    300

gacccgagtt atgcccaccc tccaactttg cgacggaaat gtgtcatcga aagccaggta    360

caccaggggt tggaaaaacc acactaggca aagaacttgc gtcaaaatca ggactgaaat    420

acattaatgt gggtgattta gctcgagaag tctgatcatc ggatatcatg gagtctggca    480

agacggcttc tcccaagagc atgccgaaag atgcacagat gatggcacaa atcctgaagg    540

atatggggat tacagaatat gagccaagag ttataaatca gatgttggag tttgccttcc    600

gatatgtgac cacaattcta gatgatgcaa aaatttattc aagccatgct aagaaagcta    660

ctgttgatgc agatgatgtg cgattggcaa tccagtgccg cgctgatcag tcttttacct    720

ctcctccccc aagagatttt ttattagata ttgcaaggca aagaaatcaa acccctttgc    780

cattgatcaa gccatattca ggtcctaggt tgccacctga tagatactgc ttaacagctc    840

caaactatag gctgaaatct ttacagaaaa aggcatcaac ttctgcggga agaataacag    900

tcccgcggtt aagtgttggt tcagttacta gcagaccaag tactcccaca ctaggcacac    960

caaccccaca gaccatgtct gtttcaacta aagtagggac tcccatgtcc ctcacaggtc   1020

aaaggtttac agtacagatg cctacttctc agtctccagc tgtaaaagct tcaattcctg   1080

caacctcagc agttcagaat gttctgatta atccatcatt aatcgggtcc aaaaacattc   1140

ttattaccac taatatgatg tcatcacaaa atactgccaa tgaatcatca aatgcattga   1200

aaagaaaacg tgaagatgat gatgatgacg atgatgatga tgatgactat gataatctgt   1260

aatctagcct tgctgaatgt aacatgtata cttggtcttg aattcattgt actgatatta   1320

aacatgcatg ctggatgttt tcaagttgtg ttttagaaaa ctaataataa tgagtaaaca   1380

cagttaccat acttttcaat tgaaatgaag gtttttcatc agccttaaaa gtgtaagaaa   1440

aataaagttg tcattcattc gaaaaaaaaa aaaaaaaaaa aa                      1482


<210>  982
<211>  264
<212>  PRT
<213>  Homosapiens

<400>  982

Met Glu Ser Gly Lys Thr Ala Ser Pro Lys Ser Met Pro Lys Asp Ala 
1               5                   10                  15      


Gln Met Met Ala Gln Ile Leu Lys Asp Met Gly Ile Thr Glu Tyr Glu 
            20                  25                  30          


Pro Arg Val Ile Asn Gln Met Leu Glu Phe Ala Phe Arg Tyr Val Thr 
        35                  40                  45              


Thr Ile Leu Asp Asp Ala Lys Ile Tyr Ser Ser His Ala Lys Lys Ala 
    50                  55                  60                  


Thr Val Asp Ala Asp Asp Val Arg Leu Ala Ile Gln Cys Arg Ala Asp 
65                  70                  75                  80  


Gln Ser Phe Thr Ser Pro Pro Pro Arg Asp Phe Leu Leu Asp Ile Ala 
                85                  90                  95      


Arg Gln Arg Asn Gln Thr Pro Leu Pro Leu Ile Lys Pro Tyr Ser Gly 
            100                 105                 110         


Pro Arg Leu Pro Pro Asp Arg Tyr Cys Leu Thr Ala Pro Asn Tyr Arg 
        115                 120                 125             


Leu Lys Ser Leu Gln Lys Lys Ala Ser Thr Ser Ala Gly Arg Ile Thr 
    130                 135                 140                 


Val Pro Arg Leu Ser Val Gly Ser Val Thr Ser Arg Pro Ser Thr Pro 
145                 150                 155                 160 


Thr Leu Gly Thr Pro Thr Pro Gln Thr Met Ser Val Ser Thr Lys Val 
                165                 170                 175     


Gly Thr Pro Met Ser Leu Thr Gly Gln Arg Phe Thr Val Gln Met Pro 
            180                 185                 190         


Thr Ser Gln Ser Pro Ala Val Lys Ala Ser Ile Pro Ala Thr Ser Ala 
        195                 200                 205             


Val Gln Asn Val Leu Ile Asn Pro Ser Leu Ile Gly Ser Lys Asn Ile 
    210                 215                 220                 


Leu Ile Thr Thr Asn Met Met Ser Ser Gln Asn Thr Ala Asn Glu Ser 
225                 230                 235                 240 


Ser Asn Ala Leu Lys Arg Lys Arg Glu Asp Asp Asp Asp Asp Asp Asp 
                245                 250                 255     


Asp Asp Asp Asp Tyr Asp Asn Leu 
            260                 


<210>  983
<211>  1245
<212>  DNA
<213>  Homosapiens

<400>  983
gtgggctttt gctgccgccc gccccttccg gctcctccct gtagagcaaa gggcacgtga     60

gcgaggcgcc cgaagccgtc gcggcgggga ccatgttgct tccgaacatc ctgctcaccg    120

gtacaccagg ggttggaaaa accacactag gcaaagaact tgcgtcaaaa tcaggactga    180

aatacattaa tgtgggtgat ttagctcgag aagtctgatc atcggatatc atggagtctg    240

gcaagacggc ttctcccaag agcatgccga aagatgcaca gatgatggca caaatcctga    300

aggatatggg gattacagaa tatgagccaa gagttataaa tcagatgttg gagtttgcct    360

tccgatatgt gaccacaatt ctagatgatg caaaaattta ttcaagccat gctaagaaag    420

ctactgttga tgcagatgat gtgcgattgg caatccagtg ccgcgctgat cagtctttta    480

cctctcctcc cccaagagat tttttattag atattgcaag gcaaagaaat caaacccctt    540

tgccattgat caagccatat tcaggtccta ggttgccacc tgatagatac tgcttaacag    600

ctccaaacta taggctgaaa tctttacaga aaaaggcatc aacttctgcg ggaagaataa    660

cagtcccgcg gttaagtgtt ggttcagtta ctagcagacc aagtactccc acactaggca    720

caccaacccc acagaccatg tctgtttcaa ctaaagtagg gactcccatg tccctcacag    780

gtcaaaggtt tacagtacag atgcctactt ctcagtctcc agctgtaaaa gcttcaattc    840

ctgcaacctc agcagttcag aatgttctga ttaatccatc attaatcggg tccaaaaaca    900

ttcttattac cactaatatg atgtcatcac aaaatactgc caatgaatca tcaaatgcat    960

tgaaaagaaa acgtgaagat gatgatgatg acgatgatga tgatgatgac tatgataatc   1020

tgtaatctag ccttgctgaa tgtaacatgt atacttggtc ttgaattcat tgtactgata   1080

ttaaacatgc atgctggatg ttttcaagtt gtgttttaga aaactaataa taatgagtaa   1140

acacagttac catacttttc aattgaaatg aaggtttttc atcagcctta aaagtgtaag   1200

aaaaataaag ttgtcattca ttcgaaaaaa aaaaaaaaaa aaaaa                   1245


<210>  984
<211>  264
<212>  PRT
<213>  Homosapiens

<400>  984

Met Glu Ser Gly Lys Thr Ala Ser Pro Lys Ser Met Pro Lys Asp Ala 
1               5                   10                  15      


Gln Met Met Ala Gln Ile Leu Lys Asp Met Gly Ile Thr Glu Tyr Glu 
            20                  25                  30          


Pro Arg Val Ile Asn Gln Met Leu Glu Phe Ala Phe Arg Tyr Val Thr 
        35                  40                  45              


Thr Ile Leu Asp Asp Ala Lys Ile Tyr Ser Ser His Ala Lys Lys Ala 
    50                  55                  60                  


Thr Val Asp Ala Asp Asp Val Arg Leu Ala Ile Gln Cys Arg Ala Asp 
65                  70                  75                  80  


Gln Ser Phe Thr Ser Pro Pro Pro Arg Asp Phe Leu Leu Asp Ile Ala 
                85                  90                  95      


Arg Gln Arg Asn Gln Thr Pro Leu Pro Leu Ile Lys Pro Tyr Ser Gly 
            100                 105                 110         


Pro Arg Leu Pro Pro Asp Arg Tyr Cys Leu Thr Ala Pro Asn Tyr Arg 
        115                 120                 125             


Leu Lys Ser Leu Gln Lys Lys Ala Ser Thr Ser Ala Gly Arg Ile Thr 
    130                 135                 140                 


Val Pro Arg Leu Ser Val Gly Ser Val Thr Ser Arg Pro Ser Thr Pro 
145                 150                 155                 160 


Thr Leu Gly Thr Pro Thr Pro Gln Thr Met Ser Val Ser Thr Lys Val 
                165                 170                 175     


Gly Thr Pro Met Ser Leu Thr Gly Gln Arg Phe Thr Val Gln Met Pro 
            180                 185                 190         


Thr Ser Gln Ser Pro Ala Val Lys Ala Ser Ile Pro Ala Thr Ser Ala 
        195                 200                 205             


Val Gln Asn Val Leu Ile Asn Pro Ser Leu Ile Gly Ser Lys Asn Ile 
    210                 215                 220                 


Leu Ile Thr Thr Asn Met Met Ser Ser Gln Asn Thr Ala Asn Glu Ser 
225                 230                 235                 240 


Ser Asn Ala Leu Lys Arg Lys Arg Glu Asp Asp Asp Asp Asp Asp Asp 
                245                 250                 255     


Asp Asp Asp Asp Tyr Asp Asn Leu 
            260                 


<210>  985
<211>  962
<212>  DNA
<213>  Homosapiens

<400>  985
gtgggctttt gctgccgccc gccccttccg gctcctccct gtagagcaaa gggcacgtga     60

gcgaggcgcc cgaagccgtc gcggcgggga ccatgttgct tccgaacatc ctgctcaccg    120

gtacaccagg ggttggaaaa accacactag gcaaagaact tgcgtcaaaa tcaggactga    180

aatacattaa tgtgggtgat ttagctcgag aagagcaatt gtatgatggc tatgatgaag    240

agtatgactg tcccatttta gatgaagaca gagtagttga tgagttagat aaccaaatga    300

gagaaggtgg agttattgtt gattaccatg gttgtgattt cttccctgaa cgctggtttc    360

atatagtttt tgtgctgaga acagatacca atgtattgta cgaaagactt gaaacaaggg    420

gttataatga gaagaaacta acagacaata ttcagtgtga gatttttcaa gttctttatg    480

aagaagccac agcatcctac aaggaagaaa tcgtgcatca gctgcccagt aataaaccag    540

aagagctaga aaataatgta gatcagatct tgaaatggat tgagcagtgg atcaaagatc    600

ataactcttg acttataagg ctagctactt aataatcact cttgttgata tctctgccga    660

catcatagaa attgttcaag tgtcagtaac actttattaa aatcatgttg cagaaccagc    720

aggtggatag tatataggtt tatgcctgtg tttctttttc tccatgagaa agctaaacat    780

gaaatataat gaatatagta ttattaagga ttgagacaaa aactgtgatt ttaatactta    840

aattgctaaa gaataaataa atctgacaaa atgggtggat atcttttaag tttattacag    900

aaaaaaatgc agatgatctc ttaaaataaa actaaagata aagcaaaaaa aaaaaaaaaa    960

aa                                                                   962


<210>  986
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  986

Met Leu Leu Pro Asn Ile Leu Leu Thr Gly Thr Pro Gly Val Gly Lys 
1               5                   10                  15      


Thr Thr Leu Gly Lys Glu Leu Ala Ser Lys Ser Gly Leu Lys Tyr Ile 
            20                  25                  30          


Asn Val Gly Asp Leu Ala Arg Glu Glu Gln Leu Tyr Asp Gly Tyr Asp 
        35                  40                  45              


Glu Glu Tyr Asp Cys Pro Ile Leu Asp Glu Asp Arg Val Val Asp Glu 
    50                  55                  60                  


Leu Asp Asn Gln Met Arg Glu Gly Gly Val Ile Val Asp Tyr His Gly 
65                  70                  75                  80  


Cys Asp Phe Phe Pro Glu Arg Trp Phe His Ile Val Phe Val Leu Arg 
                85                  90                  95      


Thr Asp Thr Asn Val Leu Tyr Glu Arg Leu Glu Thr Arg Gly Tyr Asn 
            100                 105                 110         


Glu Lys Lys Leu Thr Asp Asn Ile Gln Cys Glu Ile Phe Gln Val Leu 
        115                 120                 125             


Tyr Glu Glu Ala Thr Ala Ser Tyr Lys Glu Glu Ile Val His Gln Leu 
    130                 135                 140                 


Pro Ser Asn Lys Pro Glu Glu Leu Glu Asn Asn Val Asp Gln Ile Leu 
145                 150                 155                 160 


Lys Trp Ile Glu Gln Trp Ile Lys Asp His Asn Ser 
                165                 170         


<210>  987
<211>  3164
<212>  DNA
<213>  Homosapiens

<400>  987
acctgtatac cttttgaaac gtcacagtct ctaatcgtga acgatttggg gcggagggct     60

gaacaatgtg ttttctagtg tgtcgaggtg tttataggct atgtgtgcct ccaaactgta    120

aagtagtcca gtatactttc caatgtataa gtttgtagac cttaaacttt tcttctggct    180

aacttaaaat cgttgaattc actagtttgc ataaacattt aagaatttga aaacacggtt    240

gaaaaacagt gttaccaaga aattttgtaa taacatgttc aaatgaagac aaaaatttta    300

cagtttaaga cttaaattct tcgtccacag caagtgaatt catggtattt tacttttttg    360

ggaaatactg gaaatgaaga cctgcaactg taatttgaaa taaggaaaac tttaattttc    420

agtataaaaa ttgctcaaat agaattgcct gattttaatg acaaaagtat atgggagtcc    480

acatttatgt aagaaatgaa actataaaat gtataaataa tttgcaaatc agaattgctg    540

tcgaaagttt tactataatg aaagatattt tcatactctc aaaaatatag aggaaagggg    600

ccaagattat agtaccagtc acaatctttt gatgaggacg aaatgaatca ggtaacagac    660

tgggttgacc catcatttga tgattttcta gagtgtagtg gcgtctctac tattactgcc    720

acatcattag gtgtgaataa ctcaagtcat agaagaaaaa atgggccttc tacattagaa    780

agcagcagat ttccagcgag aaaaagagga aatctatctt ccttagaaca gatttatggt    840

ttagaaaatt caaaagaata tctgtctgaa aatgaaccat gggtggataa atataaacca    900

gaaactcagc atgaacttgc tgtgcataaa aagaaaattg aagaagtcga aacctggtta    960

aaagctcaag ttttagaaag gcaaccaaaa cagggtggat ctattttatt aataacaggt   1020

cctcctggat gtggaaagac aacgacctta aaaatactat caaaggagca tggtattcaa   1080

gtacaagagt ggattaatcc agttttacca gacttccaaa aagatgattt caaggggatg   1140

tttaatactg aatcaagctt ccatatgttt ccctatcagt ctcagatagc agttttcaaa   1200

gagtttctac taagagcgac aaagtataac aagttacaaa tgcttggaga tgatctgaga   1260

actgataaga agataattct ggttgaagat ttacctaacc agttttatcg ggattctcat   1320

actttacatg aagttctaag gaagtatgtg aggattggtc gatgtcctct tatatttata   1380

atctcggaca gtctcagtgg agataataat caaaggttat tgtttcccaa agaaattcag   1440

gaagagtgtt ctatctcaaa tattagtttc aaccctgtgg caccaacaat tatgatgaaa   1500

tttcttaatc gaatagtgac tatagaagct aacaagaatg gaggaaaaat tactgtccct   1560

gacaaaactt ctctagagtt gctctgtcag ggatgttctg gtgatatcag aagtgcaata   1620

aacagcctcc agttttcttc ttcaaaagga gaaaacaact tacggccaag gaaaaaagga   1680

atgtctttaa aatcagatgc tgtgctgtca aaatcaaaac gaagaaaaaa acctgatagg   1740

gtttttgaaa atcaagaggt ccaagctatt ggtggcaaag atgtttctct gtttctcttc   1800

agagctttgg ggaaaattct atattgtaaa agagcatctt taacagaatt agactcacct   1860

cggttgccct ctcatttatc agaatatgaa cgggatacat tacttgttga acctgaggag   1920

gtagtagaaa tgtcacacat gcctggagac ttatttaatt tatatcttca ccaaaactac   1980

atagatttct tcatggaaat tgatgatatt gtgagagcca gtgaatttct gagttttgca   2040

gatatcctca gtggtgactg gaatacacgc tctttactca gggaatatag cacatctata   2100

gctacgagag gtgtgatgca ttccaacaaa gcccgaggat atgctcattg ccaaggagga   2160

ggatcaagtt ttcgaccctt gcacaaacct cagtggtttc taataaataa aaagtatcgg   2220

gaaaattgcc tggcagcaaa agcacttttt cctgacttct gcctaccagc tttatgcctc   2280

caaactcagc tattgccata ccttgctcta ctaaccattc caatgagaaa tcaagctcag   2340

atttctttta tccaagatat tggaaggctc cctctgaagc gacactttgg aagattgaaa   2400

atggaagccc tgactgacag ggaacatgga atgatagacc ctgacagcgg agatgaagcc   2460

cagcttaatg gaggacattc tgcagaggaa tctctgggtg aacccactca agccactgtg   2520

ccggaaacct ggtctcttcc tttgagtcag aatagtgcca gtgaactgcc tgctagccag   2580

ccccagccct tttcagccca aggagacatg gaagaaaaca taataataga agactacgag   2640

agtgatggga catagaagcc agcctgctaa tcagattgct acttcacagc ttcatttttg   2700

tttcattcag tggtacttca gcagagttaa tatgcttttc tgatgaatta cacaacagtt   2760

tgttaattct tcattcttgt agtatttcat cacaagaaac ctactcttct gtcatcttga   2820

agtaaataga agatcaagcc ttcaaatctc ttaatttttt cggtatttat taaatctgtg   2880

agtggtttaa ggagcggtca gtgtgtataa agtgtgtttg aacattatgc caaatatcaa   2940

gatgtgaagg actaattcag gatgcaaaaa cgttattggg gggttgtaaa tatcaactat   3000

tcaacagttt aggatgcaat tacgagtgta aactgtgtgc cttatttaca ctttattgtc   3060

tcccgcttct cagatagttt tgatgtgttg tacagtggaa tatcttagat actttttgga   3120

aagtatttac ataagttata tcacaattaa aatgttgaat ttaa                    3164


<210>  988
<211>  670
<212>  PRT
<213>  Homosapiens

<400>  988

Met Asn Gln Val Thr Asp Trp Val Asp Pro Ser Phe Asp Asp Phe Leu 
1               5                   10                  15      


Glu Cys Ser Gly Val Ser Thr Ile Thr Ala Thr Ser Leu Gly Val Asn 
            20                  25                  30          


Asn Ser Ser His Arg Arg Lys Asn Gly Pro Ser Thr Leu Glu Ser Ser 
        35                  40                  45              


Arg Phe Pro Ala Arg Lys Arg Gly Asn Leu Ser Ser Leu Glu Gln Ile 
    50                  55                  60                  


Tyr Gly Leu Glu Asn Ser Lys Glu Tyr Leu Ser Glu Asn Glu Pro Trp 
65                  70                  75                  80  


Val Asp Lys Tyr Lys Pro Glu Thr Gln His Glu Leu Ala Val His Lys 
                85                  90                  95      


Lys Lys Ile Glu Glu Val Glu Thr Trp Leu Lys Ala Gln Val Leu Glu 
            100                 105                 110         


Arg Gln Pro Lys Gln Gly Gly Ser Ile Leu Leu Ile Thr Gly Pro Pro 
        115                 120                 125             


Gly Cys Gly Lys Thr Thr Thr Leu Lys Ile Leu Ser Lys Glu His Gly 
    130                 135                 140                 


Ile Gln Val Gln Glu Trp Ile Asn Pro Val Leu Pro Asp Phe Gln Lys 
145                 150                 155                 160 


Asp Asp Phe Lys Gly Met Phe Asn Thr Glu Ser Ser Phe His Met Phe 
                165                 170                 175     


Pro Tyr Gln Ser Gln Ile Ala Val Phe Lys Glu Phe Leu Leu Arg Ala 
            180                 185                 190         


Thr Lys Tyr Asn Lys Leu Gln Met Leu Gly Asp Asp Leu Arg Thr Asp 
        195                 200                 205             


Lys Lys Ile Ile Leu Val Glu Asp Leu Pro Asn Gln Phe Tyr Arg Asp 
    210                 215                 220                 


Ser His Thr Leu His Glu Val Leu Arg Lys Tyr Val Arg Ile Gly Arg 
225                 230                 235                 240 


Cys Pro Leu Ile Phe Ile Ile Ser Asp Ser Leu Ser Gly Asp Asn Asn 
                245                 250                 255     


Gln Arg Leu Leu Phe Pro Lys Glu Ile Gln Glu Glu Cys Ser Ile Ser 
            260                 265                 270         


Asn Ile Ser Phe Asn Pro Val Ala Pro Thr Ile Met Met Lys Phe Leu 
        275                 280                 285             


Asn Arg Ile Val Thr Ile Glu Ala Asn Lys Asn Gly Gly Lys Ile Thr 
    290                 295                 300                 


Val Pro Asp Lys Thr Ser Leu Glu Leu Leu Cys Gln Gly Cys Ser Gly 
305                 310                 315                 320 


Asp Ile Arg Ser Ala Ile Asn Ser Leu Gln Phe Ser Ser Ser Lys Gly 
                325                 330                 335     


Glu Asn Asn Leu Arg Pro Arg Lys Lys Gly Met Ser Leu Lys Ser Asp 
            340                 345                 350         


Ala Val Leu Ser Lys Ser Lys Arg Arg Lys Lys Pro Asp Arg Val Phe 
        355                 360                 365             


Glu Asn Gln Glu Val Gln Ala Ile Gly Gly Lys Asp Val Ser Leu Phe 
    370                 375                 380                 


Leu Phe Arg Ala Leu Gly Lys Ile Leu Tyr Cys Lys Arg Ala Ser Leu 
385                 390                 395                 400 


Thr Glu Leu Asp Ser Pro Arg Leu Pro Ser His Leu Ser Glu Tyr Glu 
                405                 410                 415     


Arg Asp Thr Leu Leu Val Glu Pro Glu Glu Val Val Glu Met Ser His 
            420                 425                 430         


Met Pro Gly Asp Leu Phe Asn Leu Tyr Leu His Gln Asn Tyr Ile Asp 
        435                 440                 445             


Phe Phe Met Glu Ile Asp Asp Ile Val Arg Ala Ser Glu Phe Leu Ser 
    450                 455                 460                 


Phe Ala Asp Ile Leu Ser Gly Asp Trp Asn Thr Arg Ser Leu Leu Arg 
465                 470                 475                 480 


Glu Tyr Ser Thr Ser Ile Ala Thr Arg Gly Val Met His Ser Asn Lys 
                485                 490                 495     


Ala Arg Gly Tyr Ala His Cys Gln Gly Gly Gly Ser Ser Phe Arg Pro 
            500                 505                 510         


Leu His Lys Pro Gln Trp Phe Leu Ile Asn Lys Lys Tyr Arg Glu Asn 
        515                 520                 525             


Cys Leu Ala Ala Lys Ala Leu Phe Pro Asp Phe Cys Leu Pro Ala Leu 
    530                 535                 540                 


Cys Leu Gln Thr Gln Leu Leu Pro Tyr Leu Ala Leu Leu Thr Ile Pro 
545                 550                 555                 560 


Met Arg Asn Gln Ala Gln Ile Ser Phe Ile Gln Asp Ile Gly Arg Leu 
                565                 570                 575     


Pro Leu Lys Arg His Phe Gly Arg Leu Lys Met Glu Ala Leu Thr Asp 
            580                 585                 590         


Arg Glu His Gly Met Ile Asp Pro Asp Ser Gly Asp Glu Ala Gln Leu 
        595                 600                 605             


Asn Gly Gly His Ser Ala Glu Glu Ser Leu Gly Glu Pro Thr Gln Ala 
    610                 615                 620                 


Thr Val Pro Glu Thr Trp Ser Leu Pro Leu Ser Gln Asn Ser Ala Ser 
625                 630                 635                 640 


Glu Leu Pro Ala Ser Gln Pro Gln Pro Phe Ser Ala Gln Gly Asp Met 
                645                 650                 655     


Glu Glu Asn Ile Ile Ile Glu Asp Tyr Glu Ser Asp Gly Thr 
            660                 665                 670 


<210>  989
<211>  3076
<212>  DNA
<213>  Homosapiens

<400>  989
gaggccgtac ctccgagagg ctcggcgttg agcccgggta gggccaggtg gctgcccttt     60

cacctagggt agtccctggt cgcctccgct cttcgcccaa aaggggatgc agctccggga    120

aacaagtgaa ttcatggtat tttacttttt tgggaaatac tggaaatgaa gacctgcaac    180

tgtaatttga aataaggaaa actttaattt tcagtataaa aattgctcaa atagaattgc    240

ctgattttaa tgacaaaagg tgaattatag tttaatgtac tgcaagtcct aaactacgga    300

tgggaactat tacagtttat aatgtcaaaa acttttctta gaccaaaggt atcttccaca    360

aagtatatgg gagtccacat ttatgtaaga aatgaaacta taaaatgtat aaataatttg    420

caaatcagaa ttgctgtcga aagttttact ataatgaaag atattttcat actctcaaaa    480

atatagagga aaggggccaa gattatagta ccagtcacaa tcttttgatg aggacgaaat    540

gaatcaggta acagactggg ttgacccatc atttgatgat tttctagagt gtagtggcgt    600

ctctactatt actgccacat cattaggtgt gaataactca agtcatagaa gaaaaaatgg    660

gccttctaca ttagaaagca gcagatttcc agcgagaaaa agaggaaatc tatcttcctt    720

agaacagatt tatggtttag aaaattcaaa agaatatctg tctgaaaatg aaccatgggt    780

ggataaatat aaaccagaaa ctcagcatga acttgctgtg cataaaaaga aaattgaaga    840

agtcgaaacc tggttaaaag ctcaagtttt agaaaggcaa ccaaaacagg gtggatctat    900

tttattaata acaggtcctc ctggatgtgg aaagacaacg accttaaaaa tactatcaaa    960

ggagcatggt attcaagtac aagagtggat taatccagtt ttaccagact tccaaaaaga   1020

tgatttcaag gggatgttta atactgaatc aagcttccat atgtttccct atcagtctca   1080

gatagcagtt ttcaaagagt ttctactaag agcgacaaag tataacaagt tacaaatgct   1140

tggagatgat ctgagaactg ataagaagat aattctggtt gaagatttac ctaaccagtt   1200

ttatcgggat tctcatactt tacatgaagt tctaaggaag tatgtgagga ttggtcgatg   1260

tcctcttata tttataatct cggacagtct cagtggagat aataatcaaa ggttattgtt   1320

tcccaaagaa attcaggaag agtgttctat ctcaaatatt agtttcaacc ctgtggcacc   1380

aacaattatg atgaaatttc ttaatcgaat agtgactata gaagctaaca agaatggagg   1440

aaaaattact gtccctgaca aaacttctct agagttgctc tgtcagggat gttctggtga   1500

tatcagaagt gcaataaaca gcctccagtt ttcttcttca aaaggagaaa acaacttacg   1560

gccaaggaaa aaaggaatgt ctttaaaatc agatgctgtg ctgtcaaaat caaaacgaag   1620

aaaaaaacct gatagggttt ttgaaaatca agaggtccaa gctattggtg gcaaagatgt   1680

ttctctgttt ctcttcagag ctttggggaa aattctatat tgtaaaagag catctttaac   1740

agaattagac tcacctcggt tgccctctca tttatcagaa tatgaacggg atacattact   1800

tgttgaacct gaggaggtag tagaaatgtc acacatgcct ggagacttat ttaatttata   1860

tcttcaccaa aactacatag atttcttcat ggaaattgat gatattgtga gagccagtga   1920

atttctgagt tttgcagata tcctcagtgg tgactggaat acacgctctt tactcaggga   1980

atatagcaca tctatagcta cgagaggtgt gatgcattcc aacaaagccc gaggatatgc   2040

tcattgccaa ggaggaggat caagttttcg acccttgcac aaacctcagt ggtttctaat   2100

aaataaaaag tatcgggaaa attgcctggc agcaaaagca ctttttcctg acttctgcct   2160

accagcttta tgcctccaaa ctcagctatt gccatacctt gctctactaa ccattccaat   2220

gagaaatcaa gctcagattt cttttatcca agatattgga aggctccctc tgaagcgaca   2280

ctttggaaga ttgaaaatgg aagccctgac tgacagggaa catggaatga tagaccctga   2340

cagcggagat gaagcccagc ttaatggagg acattctgca gaggaatctc tgggtgaacc   2400

cactcaagcc actgtgccgg aaacctggtc tcttcctttg agtcagaata gtgccagtga   2460

actgcctgct agccagcccc agcccttttc agcccaagga gacatggaag aaaacataat   2520

aatagaagac tacgagagtg atgggacata gaagccagcc tgctaatcag attgctactt   2580

cacagcttca tttttgtttc attcagtggt acttcagcag agttaatatg cttttctgat   2640

gaattacaca acagtttgtt aattcttcat tcttgtagta tttcatcaca agaaacctac   2700

tcttctgtca tcttgaagta aatagaagat caagccttca aatctcttaa ttttttcggt   2760

atttattaaa tctgtgagtg gtttaaggag cggtcagtgt gtataaagtg tgtttgaaca   2820

ttatgccaaa tatcaagatg tgaaggacta attcaggatg caaaaacgtt attggggggt   2880

tgtaaatatc aactattcaa cagtttagga tgcaattacg agtgtaaact gtgtgcctta   2940

tttacacttt attgtctccc gcttctcaga tagttttgat gtgttgtaca gtggaatatc   3000

ttagatactt tttggaaagt atttacataa gttatatcac aattaaaatg ttgaatttaa   3060

aaaaaaaaaa aaaaaa                                                   3076


<210>  990
<211>  670
<212>  PRT
<213>  Homosapiens

<400>  990

Met Asn Gln Val Thr Asp Trp Val Asp Pro Ser Phe Asp Asp Phe Leu 
1               5                   10                  15      


Glu Cys Ser Gly Val Ser Thr Ile Thr Ala Thr Ser Leu Gly Val Asn 
            20                  25                  30          


Asn Ser Ser His Arg Arg Lys Asn Gly Pro Ser Thr Leu Glu Ser Ser 
        35                  40                  45              


Arg Phe Pro Ala Arg Lys Arg Gly Asn Leu Ser Ser Leu Glu Gln Ile 
    50                  55                  60                  


Tyr Gly Leu Glu Asn Ser Lys Glu Tyr Leu Ser Glu Asn Glu Pro Trp 
65                  70                  75                  80  


Val Asp Lys Tyr Lys Pro Glu Thr Gln His Glu Leu Ala Val His Lys 
                85                  90                  95      


Lys Lys Ile Glu Glu Val Glu Thr Trp Leu Lys Ala Gln Val Leu Glu 
            100                 105                 110         


Arg Gln Pro Lys Gln Gly Gly Ser Ile Leu Leu Ile Thr Gly Pro Pro 
        115                 120                 125             


Gly Cys Gly Lys Thr Thr Thr Leu Lys Ile Leu Ser Lys Glu His Gly 
    130                 135                 140                 


Ile Gln Val Gln Glu Trp Ile Asn Pro Val Leu Pro Asp Phe Gln Lys 
145                 150                 155                 160 


Asp Asp Phe Lys Gly Met Phe Asn Thr Glu Ser Ser Phe His Met Phe 
                165                 170                 175     


Pro Tyr Gln Ser Gln Ile Ala Val Phe Lys Glu Phe Leu Leu Arg Ala 
            180                 185                 190         


Thr Lys Tyr Asn Lys Leu Gln Met Leu Gly Asp Asp Leu Arg Thr Asp 
        195                 200                 205             


Lys Lys Ile Ile Leu Val Glu Asp Leu Pro Asn Gln Phe Tyr Arg Asp 
    210                 215                 220                 


Ser His Thr Leu His Glu Val Leu Arg Lys Tyr Val Arg Ile Gly Arg 
225                 230                 235                 240 


Cys Pro Leu Ile Phe Ile Ile Ser Asp Ser Leu Ser Gly Asp Asn Asn 
                245                 250                 255     


Gln Arg Leu Leu Phe Pro Lys Glu Ile Gln Glu Glu Cys Ser Ile Ser 
            260                 265                 270         


Asn Ile Ser Phe Asn Pro Val Ala Pro Thr Ile Met Met Lys Phe Leu 
        275                 280                 285             


Asn Arg Ile Val Thr Ile Glu Ala Asn Lys Asn Gly Gly Lys Ile Thr 
    290                 295                 300                 


Val Pro Asp Lys Thr Ser Leu Glu Leu Leu Cys Gln Gly Cys Ser Gly 
305                 310                 315                 320 


Asp Ile Arg Ser Ala Ile Asn Ser Leu Gln Phe Ser Ser Ser Lys Gly 
                325                 330                 335     


Glu Asn Asn Leu Arg Pro Arg Lys Lys Gly Met Ser Leu Lys Ser Asp 
            340                 345                 350         


Ala Val Leu Ser Lys Ser Lys Arg Arg Lys Lys Pro Asp Arg Val Phe 
        355                 360                 365             


Glu Asn Gln Glu Val Gln Ala Ile Gly Gly Lys Asp Val Ser Leu Phe 
    370                 375                 380                 


Leu Phe Arg Ala Leu Gly Lys Ile Leu Tyr Cys Lys Arg Ala Ser Leu 
385                 390                 395                 400 


Thr Glu Leu Asp Ser Pro Arg Leu Pro Ser His Leu Ser Glu Tyr Glu 
                405                 410                 415     


Arg Asp Thr Leu Leu Val Glu Pro Glu Glu Val Val Glu Met Ser His 
            420                 425                 430         


Met Pro Gly Asp Leu Phe Asn Leu Tyr Leu His Gln Asn Tyr Ile Asp 
        435                 440                 445             


Phe Phe Met Glu Ile Asp Asp Ile Val Arg Ala Ser Glu Phe Leu Ser 
    450                 455                 460                 


Phe Ala Asp Ile Leu Ser Gly Asp Trp Asn Thr Arg Ser Leu Leu Arg 
465                 470                 475                 480 


Glu Tyr Ser Thr Ser Ile Ala Thr Arg Gly Val Met His Ser Asn Lys 
                485                 490                 495     


Ala Arg Gly Tyr Ala His Cys Gln Gly Gly Gly Ser Ser Phe Arg Pro 
            500                 505                 510         


Leu His Lys Pro Gln Trp Phe Leu Ile Asn Lys Lys Tyr Arg Glu Asn 
        515                 520                 525             


Cys Leu Ala Ala Lys Ala Leu Phe Pro Asp Phe Cys Leu Pro Ala Leu 
    530                 535                 540                 


Cys Leu Gln Thr Gln Leu Leu Pro Tyr Leu Ala Leu Leu Thr Ile Pro 
545                 550                 555                 560 


Met Arg Asn Gln Ala Gln Ile Ser Phe Ile Gln Asp Ile Gly Arg Leu 
                565                 570                 575     


Pro Leu Lys Arg His Phe Gly Arg Leu Lys Met Glu Ala Leu Thr Asp 
            580                 585                 590         


Arg Glu His Gly Met Ile Asp Pro Asp Ser Gly Asp Glu Ala Gln Leu 
        595                 600                 605             


Asn Gly Gly His Ser Ala Glu Glu Ser Leu Gly Glu Pro Thr Gln Ala 
    610                 615                 620                 


Thr Val Pro Glu Thr Trp Ser Leu Pro Leu Ser Gln Asn Ser Ala Ser 
625                 630                 635                 640 


Glu Leu Pro Ala Ser Gln Pro Gln Pro Phe Ser Ala Gln Gly Asp Met 
                645                 650                 655     


Glu Glu Asn Ile Ile Ile Glu Asp Tyr Glu Ser Asp Gly Thr 
            660                 665                 670 


<210>  991
<211>  2633
<212>  DNA
<213>  Homosapiens

<400>  991
gtgaattata gtttaatgta ctgcaagtcc taaactacgg atgggaacta ttacagttta     60

taatgtcaaa aacttttctt agaccaaagg tatcttccac aaaggtaaca gactgggttg    120

acccatcatt tgatgatttt ctagagtgta gtggcgtctc tactattact gccacatcat    180

taggtgtgaa taactcaagt catagaagaa aaaatgggcc ttctacatta gaaagcagca    240

gatttccagc gagaaaaaga ggaaatctat cttccttaga acagatttat ggtttagaaa    300

attcaaaaga atatctgtct gaaaatgaac catgggtgga taaatataaa ccagaaactc    360

agcatgaact tgctgtgcat aaaaagaaaa ttgaagaagt cgaaacctgg ttaaaagctc    420

aagttttaga aaggcaacca aaacagggtg gatctatttt attaataaca ggtcctcctg    480

gatgtggaaa gacaacgacc ttaaaaatac tatcaaagga gcatggtatt caagtacaag    540

agtggattaa tccagtttta ccagacttcc aaaaagatga tttcaagggg atgtttaata    600

ctgaatcaag cttccatatg tttccctatc agtctcagat agcagttttc aaagagtttc    660

tactaagagc gacaaagtat aacaagttac aaatgcttgg agatgatctg agaactgata    720

agaagataat tctggttgaa gatttaccta accagtttta tcgggattct catactttac    780

atgaagttct aaggaagtat gtgaggattg gtcgatgtcc tcttatattt ataatctcgg    840

acagtctcag tggagataat aatcaaaggt tattgtttcc caaagaaatt caggaagagt    900

gttctatctc aaatattagt ttcaaccctg tggcaccaac aattatgatg aaatttctta    960

atcgaatagt gactatagaa gctaacaaga atggaggaaa aattactgtc cctgacaaaa   1020

cttctctaga gttgctctgt cagggatgtt ctggtgatat cagaagtgca ataaacagcc   1080

tccagttttc ttcttcaaaa ggagaaaaca acttacggcc aaggaaaaaa ggaatgtctt   1140

taaaatcaga tgctgtgctg tcaaaatcaa aacgaagaaa aaaacctgat agggtttttg   1200

aaaatcaaga ggtccaagct attggtggca aagatgtttc tctgtttctc ttcagagctt   1260

tggggaaaat tctatattgt aaaagagcat ctttaacaga attagactca cctcggttgc   1320

cctctcattt atcagaatat gaacgggata cattacttgt tgaacctgag gaggtagtag   1380

aaatgtcaca catgcctgga gacttattta atttatatct tcaccaaaac tacatagatt   1440

tcttcatgga aattgatgat attgtgagag ccagtgaatt tctgagtttt gcagatatcc   1500

tcagtggtga ctggaataca cgctctttac tcagggaata tagcacatct atagctacga   1560

gaggtgtgat gcattccaac aaagcccgag gatatgctca ttgccaagga ggaggatcaa   1620

gttttcgacc cttgcacaaa cctcagtggt ttctaataaa taaaaagtat cgggaaaatt   1680

gcctggcagc aaaagcactt tttcctgact tctgcctacc agctttatgc ctccaaactc   1740

agctattgcc ataccttgct ctactaacca ttccaatgag aaatcaagct cagatttctt   1800

ttatccaaga tattggaagg ctccctctga agcgacactt tggaagattg aaaatggaag   1860

ccctgactga cagggaacat ggaatgatag accctgacag cggagatgaa gcccagctta   1920

atggaggaca ttctgcagag gaatctctgg gtgaacccac tcaagccact gtgccggaaa   1980

cctggtctct tcctttgagt cagaatagtg ccagtgaact gcctgctagc cagccccagc   2040

ccttttcagc ccaaggagac atggaagaaa acataataat agaagactac gagagtgatg   2100

ggacatagaa gccagcctgc taatcagatt gctacttcac agcttcattt ttgtttcatt   2160

cagtggtact tcagcagagt taatatgctt ttctgatgaa ttacacaaca gtttgttaat   2220

tcttcattct tgtagtattt catcacaaga aacctactct tctgtcatct tgaagtaaat   2280

agaagatcaa gccttcaaat ctcttaattt tttcggtatt tattaaatct gtgagtggtt   2340

taaggagcgg tcagtgtgta taaagtgtgt ttgaacatta tgccaaatat caagatgtga   2400

aggactaatt caggatgcaa aaacgttatt ggggggttgt aaatatcaac tattcaacag   2460

tttaggatgc aattacgagt gtaaactgtg tgccttattt acactttatt gtctcccgct   2520

tctcagatag ttttgatgtg ttgtacagtg gaatatctta gatacttttt ggaaagtatt   2580

tacataagtt atatcacaat taaaatgttg aatttaaaaa aaaaaaaaaa aaa          2633


<210>  992
<211>  681
<212>  PRT
<213>  Homosapiens

<400>  992

Met Ser Lys Thr Phe Leu Arg Pro Lys Val Ser Ser Thr Lys Val Thr 
1               5                   10                  15      


Asp Trp Val Asp Pro Ser Phe Asp Asp Phe Leu Glu Cys Ser Gly Val 
            20                  25                  30          


Ser Thr Ile Thr Ala Thr Ser Leu Gly Val Asn Asn Ser Ser His Arg 
        35                  40                  45              


Arg Lys Asn Gly Pro Ser Thr Leu Glu Ser Ser Arg Phe Pro Ala Arg 
    50                  55                  60                  


Lys Arg Gly Asn Leu Ser Ser Leu Glu Gln Ile Tyr Gly Leu Glu Asn 
65                  70                  75                  80  


Ser Lys Glu Tyr Leu Ser Glu Asn Glu Pro Trp Val Asp Lys Tyr Lys 
                85                  90                  95      


Pro Glu Thr Gln His Glu Leu Ala Val His Lys Lys Lys Ile Glu Glu 
            100                 105                 110         


Val Glu Thr Trp Leu Lys Ala Gln Val Leu Glu Arg Gln Pro Lys Gln 
        115                 120                 125             


Gly Gly Ser Ile Leu Leu Ile Thr Gly Pro Pro Gly Cys Gly Lys Thr 
    130                 135                 140                 


Thr Thr Leu Lys Ile Leu Ser Lys Glu His Gly Ile Gln Val Gln Glu 
145                 150                 155                 160 


Trp Ile Asn Pro Val Leu Pro Asp Phe Gln Lys Asp Asp Phe Lys Gly 
                165                 170                 175     


Met Phe Asn Thr Glu Ser Ser Phe His Met Phe Pro Tyr Gln Ser Gln 
            180                 185                 190         


Ile Ala Val Phe Lys Glu Phe Leu Leu Arg Ala Thr Lys Tyr Asn Lys 
        195                 200                 205             


Leu Gln Met Leu Gly Asp Asp Leu Arg Thr Asp Lys Lys Ile Ile Leu 
    210                 215                 220                 


Val Glu Asp Leu Pro Asn Gln Phe Tyr Arg Asp Ser His Thr Leu His 
225                 230                 235                 240 


Glu Val Leu Arg Lys Tyr Val Arg Ile Gly Arg Cys Pro Leu Ile Phe 
                245                 250                 255     


Ile Ile Ser Asp Ser Leu Ser Gly Asp Asn Asn Gln Arg Leu Leu Phe 
            260                 265                 270         


Pro Lys Glu Ile Gln Glu Glu Cys Ser Ile Ser Asn Ile Ser Phe Asn 
        275                 280                 285             


Pro Val Ala Pro Thr Ile Met Met Lys Phe Leu Asn Arg Ile Val Thr 
    290                 295                 300                 


Ile Glu Ala Asn Lys Asn Gly Gly Lys Ile Thr Val Pro Asp Lys Thr 
305                 310                 315                 320 


Ser Leu Glu Leu Leu Cys Gln Gly Cys Ser Gly Asp Ile Arg Ser Ala 
                325                 330                 335     


Ile Asn Ser Leu Gln Phe Ser Ser Ser Lys Gly Glu Asn Asn Leu Arg 
            340                 345                 350         


Pro Arg Lys Lys Gly Met Ser Leu Lys Ser Asp Ala Val Leu Ser Lys 
        355                 360                 365             


Ser Lys Arg Arg Lys Lys Pro Asp Arg Val Phe Glu Asn Gln Glu Val 
    370                 375                 380                 


Gln Ala Ile Gly Gly Lys Asp Val Ser Leu Phe Leu Phe Arg Ala Leu 
385                 390                 395                 400 


Gly Lys Ile Leu Tyr Cys Lys Arg Ala Ser Leu Thr Glu Leu Asp Ser 
                405                 410                 415     


Pro Arg Leu Pro Ser His Leu Ser Glu Tyr Glu Arg Asp Thr Leu Leu 
            420                 425                 430         


Val Glu Pro Glu Glu Val Val Glu Met Ser His Met Pro Gly Asp Leu 
        435                 440                 445             


Phe Asn Leu Tyr Leu His Gln Asn Tyr Ile Asp Phe Phe Met Glu Ile 
    450                 455                 460                 


Asp Asp Ile Val Arg Ala Ser Glu Phe Leu Ser Phe Ala Asp Ile Leu 
465                 470                 475                 480 


Ser Gly Asp Trp Asn Thr Arg Ser Leu Leu Arg Glu Tyr Ser Thr Ser 
                485                 490                 495     


Ile Ala Thr Arg Gly Val Met His Ser Asn Lys Ala Arg Gly Tyr Ala 
            500                 505                 510         


His Cys Gln Gly Gly Gly Ser Ser Phe Arg Pro Leu His Lys Pro Gln 
        515                 520                 525             


Trp Phe Leu Ile Asn Lys Lys Tyr Arg Glu Asn Cys Leu Ala Ala Lys 
    530                 535                 540                 


Ala Leu Phe Pro Asp Phe Cys Leu Pro Ala Leu Cys Leu Gln Thr Gln 
545                 550                 555                 560 


Leu Leu Pro Tyr Leu Ala Leu Leu Thr Ile Pro Met Arg Asn Gln Ala 
                565                 570                 575     


Gln Ile Ser Phe Ile Gln Asp Ile Gly Arg Leu Pro Leu Lys Arg His 
            580                 585                 590         


Phe Gly Arg Leu Lys Met Glu Ala Leu Thr Asp Arg Glu His Gly Met 
        595                 600                 605             


Ile Asp Pro Asp Ser Gly Asp Glu Ala Gln Leu Asn Gly Gly His Ser 
    610                 615                 620                 


Ala Glu Glu Ser Leu Gly Glu Pro Thr Gln Ala Thr Val Pro Glu Thr 
625                 630                 635                 640 


Trp Ser Leu Pro Leu Ser Gln Asn Ser Ala Ser Glu Leu Pro Ala Ser 
                645                 650                 655     


Gln Pro Gln Pro Phe Ser Ala Gln Gly Asp Met Glu Glu Asn Ile Ile 
            660                 665                 670         


Ile Glu Asp Tyr Glu Ser Asp Gly Thr 
        675                 680     


<210>  993
<211>  2666
<212>  DNA
<213>  Homosapiens

<400>  993
caagtgaatt catggtattt tacttttttg ggaaatactg gaaatgaaga cctgcaactg     60

taatttgaaa taaggaaaac tttaattttc agtataaaaa ttgctcaaat agaattgcct    120

gattttaatg acaaaaggta acagactggg ttgacccatc atttgatgat tttctagagt    180

gtagtggcgt ctctactatt actgccacat cattaggtgt gaataactca agtcatagaa    240

gaaaaaatgg gccttctaca ttagaaagca gcagatttcc agcgagaaaa agaggaaatc    300

tatcttcctt agaacagatt tatggtttag aaaattcaaa agaatatctg tctgaaaatg    360

aaccatgggt ggataaatat aaaccagaaa ctcagcatga acttgctgtg cataaaaaga    420

aaattgaaga agtcgaaacc tggttaaaag ctcaagtttt agaaaggcaa ccaaaacagg    480

gtggatctat tttattaata acaggtcctc ctggatgtgg aaagacaacg accttaaaaa    540

tactatcaaa ggagcatggt attcaagtac aagagtggat taatccagtt ttaccagact    600

tccaaaaaga tgatttcaag gggatgttta atactgaatc aagcttccat atgtttccct    660

atcagtctca gatagcagtt ttcaaagagt ttctactaag agcgacaaag tataacaagt    720

tacaaatgct tggagatgat ctgagaactg ataagaagat aattctggtt gaagatttac    780

ctaaccagtt ttatcgggat tctcatactt tacatgaagt tctaaggaag tatgtgagga    840

ttggtcgatg tcctcttata tttataatct cggacagtct cagtggagat aataatcaaa    900

ggttattgtt tcccaaagaa attcaggaag agtgttctat ctcaaatatt agtttcaacc    960

ctgtggcacc aacaattatg atgaaatttc ttaatcgaat agtgactata gaagctaaca   1020

agaatggagg aaaaattact gtccctgaca aaacttctct agagttgctc tgtcagggat   1080

gttctggtga tatcagaagt gcaataaaca gcctccagtt ttcttcttca aaaggagaaa   1140

acaacttacg gccaaggaaa aaaggaatgt ctttaaaatc agatgctgtg ctgtcaaaat   1200

caaaacgaag aaaaaaacct gatagggttt ttgaaaatca agaggtccaa gctattggtg   1260

gcaaagatgt ttctctgttt ctcttcagag ctttggggaa aattctatat tgtaaaagag   1320

catctttaac agaattagac tcacctcggt tgccctctca tttatcagaa tatgaacggg   1380

atacattact tgttgaacct gaggaggtag tagaaatgtc acacatgcct ggagacttat   1440

ttaatttata tcttcaccaa aactacatag atttcttcat ggaaattgat gatattgtga   1500

gagccagtga atttctgagt tttgcagata tcctcagtgg tgactggaat acacgctctt   1560

tactcaggga atatagcaca tctatagcta cgagaggtgt gatgcattcc aacaaagccc   1620

gaggatatgc tcattgccaa ggaggaggat caagttttcg acccttgcac aaacctcagt   1680

ggtttctaat aaataaaaag tatcgggaaa attgcctggc agcaaaagca ctttttcctg   1740

acttctgcct accagcttta tgcctccaaa ctcagctatt gccatacctt gctctactaa   1800

ccattccaat gagaaatcaa gctcagattt cttttatcca agatattgga aggctccctc   1860

tgaagcgaca ctttggaaga ttgaaaatgg aagccctgac tgacagggaa catggaatga   1920

tagaccctga cagcggagat gaagcccagc ttaatggagg acattctgca gaggaatctc   1980

tgggtgaacc cactcaagcc actgtgccgg aaacctggtc tcttcctttg agtcagaata   2040

gtgccagtga actgcctgct agccagcccc agcccttttc agcccaagga gacatggaag   2100

aaaacataat aatagaagac tacgagagtg atgggacata gaagccagcc tgctaatcag   2160

attgctactt cacagcttca tttttgtttc attcagtggt acttcagcag agttaatatg   2220

cttttctgat gaattacaca acagtttgtt aattcttcat tcttgtagta tttcatcaca   2280

agaaacctac tcttctgtca tcttgaagta aatagaagat caagccttca aatctcttaa   2340

ttttttcggt atttattaaa tctgtgagtg gtttaaggag cggtcagtgt gtataaagtg   2400

tgtttgaaca ttatgccaaa tatcaagatg tgaaggacta attcaggatg caaaaacgtt   2460

attggggggt tgtaaatatc aactattcaa cagtttagga tgcaattacg agtgtaaact   2520

gtgtgcctta tttacacttt attgtctccc gcttctcaga tagttttgat gtgttgtaca   2580

gtggaatatc ttagatactt tttggaaagt atttacataa gttatatcac aattaaaatg   2640

ttgaatttaa aaaaaaaaaa aaaaaa                                        2666


<210>  994
<211>  505
<212>  PRT
<213>  Homosapiens

<400>  994

Met Phe Asn Thr Glu Ser Ser Phe His Met Phe Pro Tyr Gln Ser Gln 
1               5                   10                  15      


Ile Ala Val Phe Lys Glu Phe Leu Leu Arg Ala Thr Lys Tyr Asn Lys 
            20                  25                  30          


Leu Gln Met Leu Gly Asp Asp Leu Arg Thr Asp Lys Lys Ile Ile Leu 
        35                  40                  45              


Val Glu Asp Leu Pro Asn Gln Phe Tyr Arg Asp Ser His Thr Leu His 
    50                  55                  60                  


Glu Val Leu Arg Lys Tyr Val Arg Ile Gly Arg Cys Pro Leu Ile Phe 
65                  70                  75                  80  


Ile Ile Ser Asp Ser Leu Ser Gly Asp Asn Asn Gln Arg Leu Leu Phe 
                85                  90                  95      


Pro Lys Glu Ile Gln Glu Glu Cys Ser Ile Ser Asn Ile Ser Phe Asn 
            100                 105                 110         


Pro Val Ala Pro Thr Ile Met Met Lys Phe Leu Asn Arg Ile Val Thr 
        115                 120                 125             


Ile Glu Ala Asn Lys Asn Gly Gly Lys Ile Thr Val Pro Asp Lys Thr 
    130                 135                 140                 


Ser Leu Glu Leu Leu Cys Gln Gly Cys Ser Gly Asp Ile Arg Ser Ala 
145                 150                 155                 160 


Ile Asn Ser Leu Gln Phe Ser Ser Ser Lys Gly Glu Asn Asn Leu Arg 
                165                 170                 175     


Pro Arg Lys Lys Gly Met Ser Leu Lys Ser Asp Ala Val Leu Ser Lys 
            180                 185                 190         


Ser Lys Arg Arg Lys Lys Pro Asp Arg Val Phe Glu Asn Gln Glu Val 
        195                 200                 205             


Gln Ala Ile Gly Gly Lys Asp Val Ser Leu Phe Leu Phe Arg Ala Leu 
    210                 215                 220                 


Gly Lys Ile Leu Tyr Cys Lys Arg Ala Ser Leu Thr Glu Leu Asp Ser 
225                 230                 235                 240 


Pro Arg Leu Pro Ser His Leu Ser Glu Tyr Glu Arg Asp Thr Leu Leu 
                245                 250                 255     


Val Glu Pro Glu Glu Val Val Glu Met Ser His Met Pro Gly Asp Leu 
            260                 265                 270         


Phe Asn Leu Tyr Leu His Gln Asn Tyr Ile Asp Phe Phe Met Glu Ile 
        275                 280                 285             


Asp Asp Ile Val Arg Ala Ser Glu Phe Leu Ser Phe Ala Asp Ile Leu 
    290                 295                 300                 


Ser Gly Asp Trp Asn Thr Arg Ser Leu Leu Arg Glu Tyr Ser Thr Ser 
305                 310                 315                 320 


Ile Ala Thr Arg Gly Val Met His Ser Asn Lys Ala Arg Gly Tyr Ala 
                325                 330                 335     


His Cys Gln Gly Gly Gly Ser Ser Phe Arg Pro Leu His Lys Pro Gln 
            340                 345                 350         


Trp Phe Leu Ile Asn Lys Lys Tyr Arg Glu Asn Cys Leu Ala Ala Lys 
        355                 360                 365             


Ala Leu Phe Pro Asp Phe Cys Leu Pro Ala Leu Cys Leu Gln Thr Gln 
    370                 375                 380                 


Leu Leu Pro Tyr Leu Ala Leu Leu Thr Ile Pro Met Arg Asn Gln Ala 
385                 390                 395                 400 


Gln Ile Ser Phe Ile Gln Asp Ile Gly Arg Leu Pro Leu Lys Arg His 
                405                 410                 415     


Phe Gly Arg Leu Lys Met Glu Ala Leu Thr Asp Arg Glu His Gly Met 
            420                 425                 430         


Ile Asp Pro Asp Ser Gly Asp Glu Ala Gln Leu Asn Gly Gly His Ser 
        435                 440                 445             


Ala Glu Glu Ser Leu Gly Glu Pro Thr Gln Ala Thr Val Pro Glu Thr 
    450                 455                 460                 


Trp Ser Leu Pro Leu Ser Gln Asn Ser Ala Ser Glu Leu Pro Ala Ser 
465                 470                 475                 480 


Gln Pro Gln Pro Phe Ser Ala Gln Gly Asp Met Glu Glu Asn Ile Ile 
                485                 490                 495     


Ile Glu Asp Tyr Glu Ser Asp Gly Thr 
            500                 505 


<210>  995
<211>  2592
<212>  DNA
<213>  Homosapiens

<400>  995
caagtgaatt catggtattt tacttttttg ggaaatactg gaaatgaaga cctgcaactg     60

taatttgaaa taaggaaaac tttaattttc agtataaaaa ttgctcaaat agaattgcct    120

gattttaatg acaaaagtat atgggagtcc acatttatgt aagaaatgaa actataaaat    180

gtataaataa tttgcaaatc agaattgctg tcgaaagttt tactataatg aaagatattt    240

tcatactctc aaaaatatag aggaaagggg ccaagattat agtaccagtc acaatctttt    300

gatgaggacg aaatgaatca gcatgaactt gctgtgcata aaaagaaaat tgaagaagtc    360

gaaacctggt taaaagctca agttttagaa aggcaaccaa aacagggtgg atctatttta    420

ttaataacag gtcctcctgg atgtggaaag acaacgacct taaaaatact atcaaaggag    480

catggtattc aagtacaaga gtggattaat ccagttttac cagacttcca aaaagatgat    540

ttcaagggga tgtttaatac tgaatcaagc ttccatatgt ttccctatca gtctcagata    600

gcagttttca aagagtttct actaagagcg acaaagtata acaagttaca aatgcttgga    660

gatgatctga gaactgataa gaagataatt ctggttgaag atttacctaa ccagttttat    720

cgggattctc atactttaca tgaagttcta aggaagtatg tgaggattgg tcgatgtcct    780

cttatattta taatctcgga cagtctcagt ggagataata atcaaaggtt attgtttccc    840

aaagaaattc aggaagagtg ttctatctca aatattagtt tcaaccctgt ggcaccaaca    900

attatgatga aatttcttaa tcgaatagtg actatagaag ctaacaagaa tggaggaaaa    960

attactgtcc ctgacaaaac ttctctagag ttgctctgtc agggatgttc tggtgatatc   1020

agaagtgcaa taaacagcct ccagttttct tcttcaaaag gagaaaacaa cttacggcca   1080

aggaaaaaag gaatgtcttt aaaatcagat gctgtgctgt caaaatcaaa acgaagaaaa   1140

aaacctgata gggtttttga aaatcaagag gtccaagcta ttggtggcaa agatgtttct   1200

ctgtttctct tcagagcttt ggggaaaatt ctatattgta aaagagcatc tttaacagaa   1260

ttagactcac ctcggttgcc ctctcattta tcagaatatg aacgggatac attacttgtt   1320

gaacctgagg aggtagtaga aatgtcacac atgcctggag acttatttaa tttatatctt   1380

caccaaaact acatagattt cttcatggaa attgatgata ttgtgagagc cagtgaattt   1440

ctgagttttg cagatatcct cagtggtgac tggaatacac gctctttact cagggaatat   1500

agcacatcta tagctacgag aggtgtgatg cattccaaca aagcccgagg atatgctcat   1560

tgccaaggag gaggatcaag ttttcgaccc ttgcacaaac ctcagtggtt tctaataaat   1620

aaaaagtatc gggaaaattg cctggcagca aaagcacttt ttcctgactt ctgcctacca   1680

gctttatgcc tccaaactca gctattgcca taccttgctc tactaaccat tccaatgaga   1740

aatcaagctc agatttcttt tatccaagat attggaaggc tccctctgaa gcgacacttt   1800

ggaagattga aaatggaagc cctgactgac agggaacatg gaatgataga ccctgacagc   1860

ggagatgaag cccagcttaa tggaggacat tctgcagagg aatctctggg tgaacccact   1920

caagccactg tgccggaaac ctggtctctt cctttgagtc agaatagtgc cagtgaactg   1980

cctgctagcc agccccagcc cttttcagcc caaggagaca tggaagaaaa cataataata   2040

gaagactacg agagtgatgg gacatagaag ccagcctgct aatcagattg ctacttcaca   2100

gcttcatttt tgtttcattc agtggtactt cagcagagtt aatatgcttt tctgatgaat   2160

tacacaacag tttgttaatt cttcattctt gtagtatttc atcacaagaa acctactctt   2220

ctgtcatctt gaagtaaata gaagatcaag ccttcaaatc tcttaatttt ttcggtattt   2280

attaaatctg tgagtggttt aaggagcggt cagtgtgtat aaagtgtgtt tgaacattat   2340

gccaaatatc aagatgtgaa ggactaattc aggatgcaaa aacgttattg gggggttgta   2400

aatatcaact attcaacagt ttaggatgca attacgagtg taaactgtgt gccttattta   2460

cactttattg tctcccgctt ctcagatagt tttgatgtgt tgtacagtgg aatatcttag   2520

atactttttg gaaagtattt acataagtta tatcacaatt aaaatgttga atttaaaaaa   2580

aaaaaaaaaa aa                                                       2592


<210>  996
<211>  584
<212>  PRT
<213>  Homosapiens

<400>  996

Met Asn Gln His Glu Leu Ala Val His Lys Lys Lys Ile Glu Glu Val 
1               5                   10                  15      


Glu Thr Trp Leu Lys Ala Gln Val Leu Glu Arg Gln Pro Lys Gln Gly 
            20                  25                  30          


Gly Ser Ile Leu Leu Ile Thr Gly Pro Pro Gly Cys Gly Lys Thr Thr 
        35                  40                  45              


Thr Leu Lys Ile Leu Ser Lys Glu His Gly Ile Gln Val Gln Glu Trp 
    50                  55                  60                  


Ile Asn Pro Val Leu Pro Asp Phe Gln Lys Asp Asp Phe Lys Gly Met 
65                  70                  75                  80  


Phe Asn Thr Glu Ser Ser Phe His Met Phe Pro Tyr Gln Ser Gln Ile 
                85                  90                  95      


Ala Val Phe Lys Glu Phe Leu Leu Arg Ala Thr Lys Tyr Asn Lys Leu 
            100                 105                 110         


Gln Met Leu Gly Asp Asp Leu Arg Thr Asp Lys Lys Ile Ile Leu Val 
        115                 120                 125             


Glu Asp Leu Pro Asn Gln Phe Tyr Arg Asp Ser His Thr Leu His Glu 
    130                 135                 140                 


Val Leu Arg Lys Tyr Val Arg Ile Gly Arg Cys Pro Leu Ile Phe Ile 
145                 150                 155                 160 


Ile Ser Asp Ser Leu Ser Gly Asp Asn Asn Gln Arg Leu Leu Phe Pro 
                165                 170                 175     


Lys Glu Ile Gln Glu Glu Cys Ser Ile Ser Asn Ile Ser Phe Asn Pro 
            180                 185                 190         


Val Ala Pro Thr Ile Met Met Lys Phe Leu Asn Arg Ile Val Thr Ile 
        195                 200                 205             


Glu Ala Asn Lys Asn Gly Gly Lys Ile Thr Val Pro Asp Lys Thr Ser 
    210                 215                 220                 


Leu Glu Leu Leu Cys Gln Gly Cys Ser Gly Asp Ile Arg Ser Ala Ile 
225                 230                 235                 240 


Asn Ser Leu Gln Phe Ser Ser Ser Lys Gly Glu Asn Asn Leu Arg Pro 
                245                 250                 255     


Arg Lys Lys Gly Met Ser Leu Lys Ser Asp Ala Val Leu Ser Lys Ser 
            260                 265                 270         


Lys Arg Arg Lys Lys Pro Asp Arg Val Phe Glu Asn Gln Glu Val Gln 
        275                 280                 285             


Ala Ile Gly Gly Lys Asp Val Ser Leu Phe Leu Phe Arg Ala Leu Gly 
    290                 295                 300                 


Lys Ile Leu Tyr Cys Lys Arg Ala Ser Leu Thr Glu Leu Asp Ser Pro 
305                 310                 315                 320 


Arg Leu Pro Ser His Leu Ser Glu Tyr Glu Arg Asp Thr Leu Leu Val 
                325                 330                 335     


Glu Pro Glu Glu Val Val Glu Met Ser His Met Pro Gly Asp Leu Phe 
            340                 345                 350         


Asn Leu Tyr Leu His Gln Asn Tyr Ile Asp Phe Phe Met Glu Ile Asp 
        355                 360                 365             


Asp Ile Val Arg Ala Ser Glu Phe Leu Ser Phe Ala Asp Ile Leu Ser 
    370                 375                 380                 


Gly Asp Trp Asn Thr Arg Ser Leu Leu Arg Glu Tyr Ser Thr Ser Ile 
385                 390                 395                 400 


Ala Thr Arg Gly Val Met His Ser Asn Lys Ala Arg Gly Tyr Ala His 
                405                 410                 415     


Cys Gln Gly Gly Gly Ser Ser Phe Arg Pro Leu His Lys Pro Gln Trp 
            420                 425                 430         


Phe Leu Ile Asn Lys Lys Tyr Arg Glu Asn Cys Leu Ala Ala Lys Ala 
        435                 440                 445             


Leu Phe Pro Asp Phe Cys Leu Pro Ala Leu Cys Leu Gln Thr Gln Leu 
    450                 455                 460                 


Leu Pro Tyr Leu Ala Leu Leu Thr Ile Pro Met Arg Asn Gln Ala Gln 
465                 470                 475                 480 


Ile Ser Phe Ile Gln Asp Ile Gly Arg Leu Pro Leu Lys Arg His Phe 
                485                 490                 495     


Gly Arg Leu Lys Met Glu Ala Leu Thr Asp Arg Glu His Gly Met Ile 
            500                 505                 510         


Asp Pro Asp Ser Gly Asp Glu Ala Gln Leu Asn Gly Gly His Ser Ala 
        515                 520                 525             


Glu Glu Ser Leu Gly Glu Pro Thr Gln Ala Thr Val Pro Glu Thr Trp 
    530                 535                 540                 


Ser Leu Pro Leu Ser Gln Asn Ser Ala Ser Glu Leu Pro Ala Ser Gln 
545                 550                 555                 560 


Pro Gln Pro Phe Ser Ala Gln Gly Asp Met Glu Glu Asn Ile Ile Ile 
                565                 570                 575     


Glu Asp Tyr Glu Ser Asp Gly Thr 
            580                 


<210>  997
<211>  2972
<212>  DNA
<213>  Homosapiens

<400>  997
gaggccgtac ctccgagagg ctcggcgttg agcccgggta gggccaggtg gctgcccttt     60

cacctagggt agtccctggt cgcctccgct cttcgcccaa aaggggatgc agctccggga    120

aacaagtgaa ttcatggtat tttacttttt tgggaaatac tggaaatgaa gacctgcaac    180

tgtaatttga aataaggaaa actttaattt tcagtataaa aattgctcaa atagaattgc    240

ctgattttaa tgacaaaagt atatgggagt ccacatttat gtaagaaatg aaactataaa    300

atgtataaat aatttgcaaa tcagaattgc tgtcgaaagt tttactataa tgaaagatat    360

tttcatactc tcaaaaatat agaggaaagg ggccaagatt atagtaccag tcacaatctt    420

ttgatgagga cgaaatgaat caggtaacag actgggttga cccatcattt gatgattttc    480

tagagtgtag tggcgtctct actattactg ccacatcatt aggtgtgaat aactcaagtc    540

atagaagaaa aaatgggcct tctacattag aaagcagcag atttccagcg agaaaaagag    600

gaaatctatc ttccttagaa cagatttatg gtttagaaaa ttcaaaagaa tatctgtctg    660

aaaatgaacc atgggtggat aaatataaac cagaaactca gcatgaactt gctgtgcata    720

aaaagaaaat tgaagaagtc gaaacctggt taaaagctca agttttagaa aggcaaccaa    780

aacagggtgg atctatttta ttaataacag gtcctcctgg atgtggaaag acaacgacct    840

taaaaatact atcaaaggag catggtattc aagtacaaga gtggattaat ccagttttac    900

cagacttcca aaaagatgat ttcaagggga tgtttaatac tgaatcaagc ttccatatgt    960

ttccctatca gtctcagata gcagttttca aagagtttct actaagagcg acaaagtata   1020

acaagttaca aatgcttgga gatgatctga gaactgataa gaagataatt ctggttgaag   1080

atttacctaa ccagttttat cgggattctc atactttaca tgaagttcta aggaagtatg   1140

tgaggattgg tcgatgtcct cttatattta taatctcgga cagtctcagt ggagataata   1200

atcaaaggtt attgtttccc aaagaaattc aggaagagtg ttctatctca aatattagtt   1260

tcaaccctgt ggcaccaaca attatgatga aatttcttaa tcgaatagtg actatagaag   1320

ctaacaagaa tggaggaaaa attactgtcc ctgacaaaac ttctctagag ttgctctgtc   1380

agggatgttc tggtgatatc agaagtgcaa taaacagcct ccagttttct tcttcaaaag   1440

gagaaaacaa cttacggcca aggaaaaaag gaatgtcttt aaaatcagat gctgtgctgt   1500

caaaatcaaa acgaagaaaa aaacctgata gggtttttga aaatcaagag gtccaagcta   1560

ttggtggcaa agatgtttct ctgtttctct tcagagcttt ggggaaaatt ctatattgta   1620

aaagagcatc tttaacagaa ttagactcac ctcggttgcc ctctcattta tcagaatatg   1680

aacgggatac attacttgtt gaacctgagg aggtagtaga aatgtcacac atgcctggag   1740

acttatttaa tttatatctt caccaaaact acatagattt cttcatggaa attgatgata   1800

ttgtgagagc cagtgaattt ctgagttttg cagatatcct cagtggtgac tggaatacac   1860

gctctttact cagggaatat agcacatcta tagctacgag aggtgtgatg cattccaaca   1920

aagcccgagg atatgctcat tgccaaggag gaggatcaag ttttcgaccc ttgcacaaac   1980

ctcagtggtt tctaataaat aaaaagtatc gggaaaattg cctggcagca aaagcacttt   2040

ttcctgactt ctgcctacca gctttatgcc tccaaactca gctattgcca taccttgctc   2100

tactaaccat tccaatgaga aatcaagctc agatttcttt tatccaagat attggaaggc   2160

tccctctgaa gcgacacttt ggaagattga aaatggaagc cctgactgac agggaacatg   2220

gaatgataga ccctgacagc ggagatgaag cccagcttaa tggaggacat tctgcagagg   2280

aatctctggg tgaacccact caagccactg tgccggaaac ctggtctctt cctttgagtc   2340

agaatagtgc cagtgaactg cctgctagcc agccccagcc cttttcagcc caaggagaca   2400

tggaagaaaa cataataata gaagactacg agagtgatgg gacatagaag ccagcctgct   2460

aatcagattg ctacttcaca gcttcatttt tgtttcattc agtggtactt cagcagagtt   2520

aatatgcttt tctgatgaat tacacaacag tttgttaatt cttcattctt gtagtatttc   2580

atcacaagaa acctactctt ctgtcatctt gaagtaaata gaagatcaag ccttcaaatc   2640

tcttaatttt ttcggtattt attaaatctg tgagtggttt aaggagcggt cagtgtgtat   2700

aaagtgtgtt tgaacattat gccaaatatc aagatgtgaa ggactaattc aggatgcaaa   2760

aacgttattg gggggttgta aatatcaact attcaacagt ttaggatgca attacgagtg   2820

taaactgtgt gccttattta cactttattg tctcccgctt ctcagatagt tttgatgtgt   2880

tgtacagtgg aatatcttag atactttttg gaaagtattt acataagtta tatcacaatt   2940

aaaatgttga atttaaaaaa aaaaaaaaaa aa                                 2972


<210>  998
<211>  670
<212>  PRT
<213>  Homosapiens

<400>  998

Met Asn Gln Val Thr Asp Trp Val Asp Pro Ser Phe Asp Asp Phe Leu 
1               5                   10                  15      


Glu Cys Ser Gly Val Ser Thr Ile Thr Ala Thr Ser Leu Gly Val Asn 
            20                  25                  30          


Asn Ser Ser His Arg Arg Lys Asn Gly Pro Ser Thr Leu Glu Ser Ser 
        35                  40                  45              


Arg Phe Pro Ala Arg Lys Arg Gly Asn Leu Ser Ser Leu Glu Gln Ile 
    50                  55                  60                  


Tyr Gly Leu Glu Asn Ser Lys Glu Tyr Leu Ser Glu Asn Glu Pro Trp 
65                  70                  75                  80  


Val Asp Lys Tyr Lys Pro Glu Thr Gln His Glu Leu Ala Val His Lys 
                85                  90                  95      


Lys Lys Ile Glu Glu Val Glu Thr Trp Leu Lys Ala Gln Val Leu Glu 
            100                 105                 110         


Arg Gln Pro Lys Gln Gly Gly Ser Ile Leu Leu Ile Thr Gly Pro Pro 
        115                 120                 125             


Gly Cys Gly Lys Thr Thr Thr Leu Lys Ile Leu Ser Lys Glu His Gly 
    130                 135                 140                 


Ile Gln Val Gln Glu Trp Ile Asn Pro Val Leu Pro Asp Phe Gln Lys 
145                 150                 155                 160 


Asp Asp Phe Lys Gly Met Phe Asn Thr Glu Ser Ser Phe His Met Phe 
                165                 170                 175     


Pro Tyr Gln Ser Gln Ile Ala Val Phe Lys Glu Phe Leu Leu Arg Ala 
            180                 185                 190         


Thr Lys Tyr Asn Lys Leu Gln Met Leu Gly Asp Asp Leu Arg Thr Asp 
        195                 200                 205             


Lys Lys Ile Ile Leu Val Glu Asp Leu Pro Asn Gln Phe Tyr Arg Asp 
    210                 215                 220                 


Ser His Thr Leu His Glu Val Leu Arg Lys Tyr Val Arg Ile Gly Arg 
225                 230                 235                 240 


Cys Pro Leu Ile Phe Ile Ile Ser Asp Ser Leu Ser Gly Asp Asn Asn 
                245                 250                 255     


Gln Arg Leu Leu Phe Pro Lys Glu Ile Gln Glu Glu Cys Ser Ile Ser 
            260                 265                 270         


Asn Ile Ser Phe Asn Pro Val Ala Pro Thr Ile Met Met Lys Phe Leu 
        275                 280                 285             


Asn Arg Ile Val Thr Ile Glu Ala Asn Lys Asn Gly Gly Lys Ile Thr 
    290                 295                 300                 


Val Pro Asp Lys Thr Ser Leu Glu Leu Leu Cys Gln Gly Cys Ser Gly 
305                 310                 315                 320 


Asp Ile Arg Ser Ala Ile Asn Ser Leu Gln Phe Ser Ser Ser Lys Gly 
                325                 330                 335     


Glu Asn Asn Leu Arg Pro Arg Lys Lys Gly Met Ser Leu Lys Ser Asp 
            340                 345                 350         


Ala Val Leu Ser Lys Ser Lys Arg Arg Lys Lys Pro Asp Arg Val Phe 
        355                 360                 365             


Glu Asn Gln Glu Val Gln Ala Ile Gly Gly Lys Asp Val Ser Leu Phe 
    370                 375                 380                 


Leu Phe Arg Ala Leu Gly Lys Ile Leu Tyr Cys Lys Arg Ala Ser Leu 
385                 390                 395                 400 


Thr Glu Leu Asp Ser Pro Arg Leu Pro Ser His Leu Ser Glu Tyr Glu 
                405                 410                 415     


Arg Asp Thr Leu Leu Val Glu Pro Glu Glu Val Val Glu Met Ser His 
            420                 425                 430         


Met Pro Gly Asp Leu Phe Asn Leu Tyr Leu His Gln Asn Tyr Ile Asp 
        435                 440                 445             


Phe Phe Met Glu Ile Asp Asp Ile Val Arg Ala Ser Glu Phe Leu Ser 
    450                 455                 460                 


Phe Ala Asp Ile Leu Ser Gly Asp Trp Asn Thr Arg Ser Leu Leu Arg 
465                 470                 475                 480 


Glu Tyr Ser Thr Ser Ile Ala Thr Arg Gly Val Met His Ser Asn Lys 
                485                 490                 495     


Ala Arg Gly Tyr Ala His Cys Gln Gly Gly Gly Ser Ser Phe Arg Pro 
            500                 505                 510         


Leu His Lys Pro Gln Trp Phe Leu Ile Asn Lys Lys Tyr Arg Glu Asn 
        515                 520                 525             


Cys Leu Ala Ala Lys Ala Leu Phe Pro Asp Phe Cys Leu Pro Ala Leu 
    530                 535                 540                 


Cys Leu Gln Thr Gln Leu Leu Pro Tyr Leu Ala Leu Leu Thr Ile Pro 
545                 550                 555                 560 


Met Arg Asn Gln Ala Gln Ile Ser Phe Ile Gln Asp Ile Gly Arg Leu 
                565                 570                 575     


Pro Leu Lys Arg His Phe Gly Arg Leu Lys Met Glu Ala Leu Thr Asp 
            580                 585                 590         


Arg Glu His Gly Met Ile Asp Pro Asp Ser Gly Asp Glu Ala Gln Leu 
        595                 600                 605             


Asn Gly Gly His Ser Ala Glu Glu Ser Leu Gly Glu Pro Thr Gln Ala 
    610                 615                 620                 


Thr Val Pro Glu Thr Trp Ser Leu Pro Leu Ser Gln Asn Ser Ala Ser 
625                 630                 635                 640 


Glu Leu Pro Ala Ser Gln Pro Gln Pro Phe Ser Ala Gln Gly Asp Met 
                645                 650                 655     


Glu Glu Asn Ile Ile Ile Glu Asp Tyr Glu Ser Asp Gly Thr 
            660                 665                 670 


<210>  999
<211>  3010
<212>  DNA
<213>  Homosapiens

<400>  999
gcaacgcccg cgagggtcgg ctcccggggc gctgacaacc gcctcgtggc cctcggccgg     60

cctctgaaga gggcagtgag gggcccccac ctgggcgccc gatgcccaga gcactctgcg    120

cccccagcct gccccagccc agtccctccc ggccgcgcgc cctgaccgca agtgaattca    180

tggtatttta cttttttggg aaatactgga aatgaagacc tgcaactgta atttgaaata    240

aggaaaactt taattttcag tataaaaatt gctcaaatag aattgcctga ttttaatgac    300

aaaagtatat gggagtccac atttatgtaa gaaatgaaac tataaaatgt ataaataatt    360

tgcaaatcag aattgctgtc gaaagtttta ctataatgaa agatattttc atactctcaa    420

aaatatagag gaaaggggcc aagattatag taccagtcac aatcttttga tgaggacgaa    480

atgaatcagg taacagactg ggttgaccca tcatttgatg attttctaga gtgtagtggc    540

gtctctacta ttactgccac atcattaggt gtgaataact caagtcatag aagaaaaaat    600

gggccttcta cattagaaag cagcagattt ccagcgagaa aaagaggaaa tctatcttcc    660

ttagaacaga tttatggttt agaaaattca aaagaatatc tgtctgaaaa tgaaccatgg    720

gtggataaat ataaaccaga aactcagcat gaacttgctg tgcataaaaa gaaaattgaa    780

gaagtcgaaa cctggttaaa agctcaagtt ttagaaaggc aaccaaaaca gggtggatct    840

attttattaa taacaggtcc tcctggatgt ggaaagacaa cgaccttaaa aatactatca    900

aaggagcatg gtattcaagt acaagagtgg attaatccag ttttaccaga cttccaaaaa    960

gatgatttca aggggatgtt taatactgaa tcaagcttcc atatgtttcc ctatcagtct   1020

cagatagcag ttttcaaaga gtttctacta agagcgacaa agtataacaa gttacaaatg   1080

cttggagatg atctgagaac tgataagaag ataattctgg ttgaagattt acctaaccag   1140

ttttatcggg attctcatac tttacatgaa gttctaagga agtatgtgag gattggtcga   1200

tgtcctctta tatttataat ctcggacagt ctcagtggag ataataatca aaggttattg   1260

tttcccaaag aaattcagga agagtgttct atctcaaata ttagtttcaa ccctgtggca   1320

ccaacaatta tgatgaaatt tcttaatcga atagtgacta tagaagctaa caagaatgga   1380

ggaaaaatta ctgtccctga caaaacttct ctagagttgc tctgtcaggg atgttctggt   1440

gatatcagaa gtgcaataaa cagcctccag ttttcttctt caaaaggaga aaacaactta   1500

cggccaagga aaaaaggaat gtctttaaaa tcagatgctg tgctgtcaaa atcaaaacga   1560

agaaaaaaac ctgatagggt ttttgaaaat caagaggtcc aagctattgg tggcaaagat   1620

gtttctctgt ttctcttcag agctttgggg aaaattctat attgtaaaag agcatcttta   1680

acagaattag actcacctcg gttgccctct catttatcag aatatgaacg ggatacatta   1740

cttgttgaac ctgaggaggt agtagaaatg tcacacatgc ctggagactt atttaattta   1800

tatcttcacc aaaactacat agatttcttc atggaaattg atgatattgt gagagccagt   1860

gaatttctga gttttgcaga tatcctcagt ggtgactgga atacacgctc tttactcagg   1920

gaatatagca catctatagc tacgagaggt gtgatgcatt ccaacaaagc ccgaggatat   1980

gctcattgcc aaggaggagg atcaagtttt cgacccttgc acaaacctca gtggtttcta   2040

ataaataaaa agtatcggga aaattgcctg gcagcaaaag cactttttcc tgacttctgc   2100

ctaccagctt tatgcctcca aactcagcta ttgccatacc ttgctctact aaccattcca   2160

atgagaaatc aagctcagat ttcttttatc caagatattg gaaggctccc tctgaagcga   2220

cactttggaa gattgaaaat ggaagccctg actgacaggg aacatggaat gatagaccct   2280

gacagcggag atgaagccca gcttaatgga ggacattctg cagaggaatc tctgggtgaa   2340

cccactcaag ccactgtgcc ggaaacctgg tctcttcctt tgagtcagaa tagtgccagt   2400

gaactgcctg ctagccagcc ccagcccttt tcagcccaag gagacatgga agaaaacata   2460

ataatagaag actacgagag tgatgggaca tagaagccag cctgctaatc agattgctac   2520

ttcacagctt catttttgtt tcattcagtg gtacttcagc agagttaata tgcttttctg   2580

atgaattaca caacagtttg ttaattcttc attcttgtag tatttcatca caagaaacct   2640

actcttctgt catcttgaag taaatagaag atcaagcctt caaatctctt aattttttcg   2700

gtatttatta aatctgtgag tggtttaagg agcggtcagt gtgtataaag tgtgtttgaa   2760

cattatgcca aatatcaaga tgtgaaggac taattcagga tgcaaaaacg ttattggggg   2820

gttgtaaata tcaactattc aacagtttag gatgcaatta cgagtgtaaa ctgtgtgcct   2880

tatttacact ttattgtctc ccgcttctca gatagttttg atgtgttgta cagtggaata   2940

tcttagatac tttttggaaa gtatttacat aagttatatc acaattaaaa tgttgaattt   3000

aaaaaaaaaa                                                          3010


<210>  1000
<211>  670
<212>  PRT
<213>  Homosapiens

<400>  1000

Met Asn Gln Val Thr Asp Trp Val Asp Pro Ser Phe Asp Asp Phe Leu 
1               5                   10                  15      


Glu Cys Ser Gly Val Ser Thr Ile Thr Ala Thr Ser Leu Gly Val Asn 
            20                  25                  30          


Asn Ser Ser His Arg Arg Lys Asn Gly Pro Ser Thr Leu Glu Ser Ser 
        35                  40                  45              


Arg Phe Pro Ala Arg Lys Arg Gly Asn Leu Ser Ser Leu Glu Gln Ile 
    50                  55                  60                  


Tyr Gly Leu Glu Asn Ser Lys Glu Tyr Leu Ser Glu Asn Glu Pro Trp 
65                  70                  75                  80  


Val Asp Lys Tyr Lys Pro Glu Thr Gln His Glu Leu Ala Val His Lys 
                85                  90                  95      


Lys Lys Ile Glu Glu Val Glu Thr Trp Leu Lys Ala Gln Val Leu Glu 
            100                 105                 110         


Arg Gln Pro Lys Gln Gly Gly Ser Ile Leu Leu Ile Thr Gly Pro Pro 
        115                 120                 125             


Gly Cys Gly Lys Thr Thr Thr Leu Lys Ile Leu Ser Lys Glu His Gly 
    130                 135                 140                 


Ile Gln Val Gln Glu Trp Ile Asn Pro Val Leu Pro Asp Phe Gln Lys 
145                 150                 155                 160 


Asp Asp Phe Lys Gly Met Phe Asn Thr Glu Ser Ser Phe His Met Phe 
                165                 170                 175     


Pro Tyr Gln Ser Gln Ile Ala Val Phe Lys Glu Phe Leu Leu Arg Ala 
            180                 185                 190         


Thr Lys Tyr Asn Lys Leu Gln Met Leu Gly Asp Asp Leu Arg Thr Asp 
        195                 200                 205             


Lys Lys Ile Ile Leu Val Glu Asp Leu Pro Asn Gln Phe Tyr Arg Asp 
    210                 215                 220                 


Ser His Thr Leu His Glu Val Leu Arg Lys Tyr Val Arg Ile Gly Arg 
225                 230                 235                 240 


Cys Pro Leu Ile Phe Ile Ile Ser Asp Ser Leu Ser Gly Asp Asn Asn 
                245                 250                 255     


Gln Arg Leu Leu Phe Pro Lys Glu Ile Gln Glu Glu Cys Ser Ile Ser 
            260                 265                 270         


Asn Ile Ser Phe Asn Pro Val Ala Pro Thr Ile Met Met Lys Phe Leu 
        275                 280                 285             


Asn Arg Ile Val Thr Ile Glu Ala Asn Lys Asn Gly Gly Lys Ile Thr 
    290                 295                 300                 


Val Pro Asp Lys Thr Ser Leu Glu Leu Leu Cys Gln Gly Cys Ser Gly 
305                 310                 315                 320 


Asp Ile Arg Ser Ala Ile Asn Ser Leu Gln Phe Ser Ser Ser Lys Gly 
                325                 330                 335     


Glu Asn Asn Leu Arg Pro Arg Lys Lys Gly Met Ser Leu Lys Ser Asp 
            340                 345                 350         


Ala Val Leu Ser Lys Ser Lys Arg Arg Lys Lys Pro Asp Arg Val Phe 
        355                 360                 365             


Glu Asn Gln Glu Val Gln Ala Ile Gly Gly Lys Asp Val Ser Leu Phe 
    370                 375                 380                 


Leu Phe Arg Ala Leu Gly Lys Ile Leu Tyr Cys Lys Arg Ala Ser Leu 
385                 390                 395                 400 


Thr Glu Leu Asp Ser Pro Arg Leu Pro Ser His Leu Ser Glu Tyr Glu 
                405                 410                 415     


Arg Asp Thr Leu Leu Val Glu Pro Glu Glu Val Val Glu Met Ser His 
            420                 425                 430         


Met Pro Gly Asp Leu Phe Asn Leu Tyr Leu His Gln Asn Tyr Ile Asp 
        435                 440                 445             


Phe Phe Met Glu Ile Asp Asp Ile Val Arg Ala Ser Glu Phe Leu Ser 
    450                 455                 460                 


Phe Ala Asp Ile Leu Ser Gly Asp Trp Asn Thr Arg Ser Leu Leu Arg 
465                 470                 475                 480 


Glu Tyr Ser Thr Ser Ile Ala Thr Arg Gly Val Met His Ser Asn Lys 
                485                 490                 495     


Ala Arg Gly Tyr Ala His Cys Gln Gly Gly Gly Ser Ser Phe Arg Pro 
            500                 505                 510         


Leu His Lys Pro Gln Trp Phe Leu Ile Asn Lys Lys Tyr Arg Glu Asn 
        515                 520                 525             


Cys Leu Ala Ala Lys Ala Leu Phe Pro Asp Phe Cys Leu Pro Ala Leu 
    530                 535                 540                 


Cys Leu Gln Thr Gln Leu Leu Pro Tyr Leu Ala Leu Leu Thr Ile Pro 
545                 550                 555                 560 


Met Arg Asn Gln Ala Gln Ile Ser Phe Ile Gln Asp Ile Gly Arg Leu 
                565                 570                 575     


Pro Leu Lys Arg His Phe Gly Arg Leu Lys Met Glu Ala Leu Thr Asp 
            580                 585                 590         


Arg Glu His Gly Met Ile Asp Pro Asp Ser Gly Asp Glu Ala Gln Leu 
        595                 600                 605             


Asn Gly Gly His Ser Ala Glu Glu Ser Leu Gly Glu Pro Thr Gln Ala 
    610                 615                 620                 


Thr Val Pro Glu Thr Trp Ser Leu Pro Leu Ser Gln Asn Ser Ala Ser 
625                 630                 635                 640 


Glu Leu Pro Ala Ser Gln Pro Gln Pro Phe Ser Ala Gln Gly Asp Met 
                645                 650                 655     


Glu Glu Asn Ile Ile Ile Glu Asp Tyr Glu Ser Asp Gly Thr 
            660                 665                 670 


<210>  1001
<211>  2842
<212>  DNA
<213>  Homosapiens

<400>  1001
gaggccgtac ctccgagagg ctcggcgttg agcccgggta gggccaggtg gctgcccttt     60

cacctagggt agtccctggt cgcctccgct cttcgcccaa aaggggatgc agctccggga    120

aatatatggg agtccacatt tatgtaagaa atgaaactat aaaatgtata aataatttgc    180

aaatcagaat tgctgtcgaa agttttacta taatgaaaga tattttcata ctctcaaaaa    240

tatagaggaa aggggccaag attatagtac cagtcacaat cttttgatga ggacgaaatg    300

aatcaggtaa cagactgggt tgacccatca tttgatgatt ttctagagtg tagtggcgtc    360

tctactatta ctgccacatc attaggtgtg aataactcaa gtcatagaag aaaaaatggg    420

ccttctacat tagaaagcag cagatttcca gcgagaaaaa gaggaaatct atcttcctta    480

gaacagattt atggtttaga aaattcaaaa gaatatctgt ctgaaaatga accatgggtg    540

gataaatata aaccagaaac tcagcatgaa cttgctgtgc ataaaaagaa aattgaagaa    600

gtcgaaacct ggttaaaagc tcaagtttta gaaaggcaac caaaacaggg tggatctatt    660

ttattaataa caggtcctcc tggatgtgga aagacaacga ccttaaaaat actatcaaag    720

gagcatggta ttcaagtaca agagtggatt aatccagttt taccagactt ccaaaaagat    780

gatttcaagg ggatgtttaa tactgaatca agcttccata tgtttcccta tcagtctcag    840

atagcagttt tcaaagagtt tctactaaga gcgacaaagt ataacaagtt acaaatgctt    900

ggagatgatc tgagaactga taagaagata attctggttg aagatttacc taaccagttt    960

tatcgggatt ctcatacttt acatgaagtt ctaaggaagt atgtgaggat tggtcgatgt   1020

cctcttatat ttataatctc ggacagtctc agtggagata ataatcaaag gttattgttt   1080

cccaaagaaa ttcaggaaga gtgttctatc tcaaatatta gtttcaaccc tgtggcacca   1140

acaattatga tgaaatttct taatcgaata gtgactatag aagctaacaa gaatggagga   1200

aaaattactg tccctgacaa aacttctcta gagttgctct gtcagggatg ttctggtgat   1260

atcagaagtg caataaacag cctccagttt tcttcttcaa aaggagaaaa caacttacgg   1320

ccaaggaaaa aaggaatgtc tttaaaatca gatgctgtgc tgtcaaaatc aaaacgaaga   1380

aaaaaacctg atagggtttt tgaaaatcaa gaggtccaag ctattggtgg caaagatgtt   1440

tctctgtttc tcttcagagc tttggggaaa attctatatt gtaaaagagc atctttaaca   1500

gaattagact cacctcggtt gccctctcat ttatcagaat atgaacggga tacattactt   1560

gttgaacctg aggaggtagt agaaatgtca cacatgcctg gagacttatt taatttatat   1620

cttcaccaaa actacataga tttcttcatg gaaattgatg atattgtgag agccagtgaa   1680

tttctgagtt ttgcagatat cctcagtggt gactggaata cacgctcttt actcagggaa   1740

tatagcacat ctatagctac gagaggtgtg atgcattcca acaaagcccg aggatatgct   1800

cattgccaag gaggaggatc aagttttcga cccttgcaca aacctcagtg gtttctaata   1860

aataaaaagt atcgggaaaa ttgcctggca gcaaaagcac tttttcctga cttctgccta   1920

ccagctttat gcctccaaac tcagctattg ccataccttg ctctactaac cattccaatg   1980

agaaatcaag ctcagatttc ttttatccaa gatattggaa ggctccctct gaagcgacac   2040

tttggaagat tgaaaatgga agccctgact gacagggaac atggaatgat agaccctgac   2100

agcggagatg aagcccagct taatggagga cattctgcag aggaatctct gggtgaaccc   2160

actcaagcca ctgtgccgga aacctggtct cttcctttga gtcagaatag tgccagtgaa   2220

ctgcctgcta gccagcccca gcccttttca gcccaaggag acatggaaga aaacataata   2280

atagaagact acgagagtga tgggacatag aagccagcct gctaatcaga ttgctacttc   2340

acagcttcat ttttgtttca ttcagtggta cttcagcaga gttaatatgc ttttctgatg   2400

aattacacaa cagtttgtta attcttcatt cttgtagtat ttcatcacaa gaaacctact   2460

cttctgtcat cttgaagtaa atagaagatc aagccttcaa atctcttaat tttttcggta   2520

tttattaaat ctgtgagtgg tttaaggagc ggtcagtgtg tataaagtgt gtttgaacat   2580

tatgccaaat atcaagatgt gaaggactaa ttcaggatgc aaaaacgtta ttggggggtt   2640

gtaaatatca actattcaac agtttaggat gcaattacga gtgtaaactg tgtgccttat   2700

ttacacttta ttgtctcccg cttctcagat agttttgatg tgttgtacag tggaatatct   2760

tagatacttt ttggaaagta tttacataag ttatatcaca attaaaatgt tgaatttaaa   2820

aaaaaaaaaa aaaaaaaaaa aa                                            2842


<210>  1002
<211>  670
<212>  PRT
<213>  Homosapiens

<400>  1002

Met Asn Gln Val Thr Asp Trp Val Asp Pro Ser Phe Asp Asp Phe Leu 
1               5                   10                  15      


Glu Cys Ser Gly Val Ser Thr Ile Thr Ala Thr Ser Leu Gly Val Asn 
            20                  25                  30          


Asn Ser Ser His Arg Arg Lys Asn Gly Pro Ser Thr Leu Glu Ser Ser 
        35                  40                  45              


Arg Phe Pro Ala Arg Lys Arg Gly Asn Leu Ser Ser Leu Glu Gln Ile 
    50                  55                  60                  


Tyr Gly Leu Glu Asn Ser Lys Glu Tyr Leu Ser Glu Asn Glu Pro Trp 
65                  70                  75                  80  


Val Asp Lys Tyr Lys Pro Glu Thr Gln His Glu Leu Ala Val His Lys 
                85                  90                  95      


Lys Lys Ile Glu Glu Val Glu Thr Trp Leu Lys Ala Gln Val Leu Glu 
            100                 105                 110         


Arg Gln Pro Lys Gln Gly Gly Ser Ile Leu Leu Ile Thr Gly Pro Pro 
        115                 120                 125             


Gly Cys Gly Lys Thr Thr Thr Leu Lys Ile Leu Ser Lys Glu His Gly 
    130                 135                 140                 


Ile Gln Val Gln Glu Trp Ile Asn Pro Val Leu Pro Asp Phe Gln Lys 
145                 150                 155                 160 


Asp Asp Phe Lys Gly Met Phe Asn Thr Glu Ser Ser Phe His Met Phe 
                165                 170                 175     


Pro Tyr Gln Ser Gln Ile Ala Val Phe Lys Glu Phe Leu Leu Arg Ala 
            180                 185                 190         


Thr Lys Tyr Asn Lys Leu Gln Met Leu Gly Asp Asp Leu Arg Thr Asp 
        195                 200                 205             


Lys Lys Ile Ile Leu Val Glu Asp Leu Pro Asn Gln Phe Tyr Arg Asp 
    210                 215                 220                 


Ser His Thr Leu His Glu Val Leu Arg Lys Tyr Val Arg Ile Gly Arg 
225                 230                 235                 240 


Cys Pro Leu Ile Phe Ile Ile Ser Asp Ser Leu Ser Gly Asp Asn Asn 
                245                 250                 255     


Gln Arg Leu Leu Phe Pro Lys Glu Ile Gln Glu Glu Cys Ser Ile Ser 
            260                 265                 270         


Asn Ile Ser Phe Asn Pro Val Ala Pro Thr Ile Met Met Lys Phe Leu 
        275                 280                 285             


Asn Arg Ile Val Thr Ile Glu Ala Asn Lys Asn Gly Gly Lys Ile Thr 
    290                 295                 300                 


Val Pro Asp Lys Thr Ser Leu Glu Leu Leu Cys Gln Gly Cys Ser Gly 
305                 310                 315                 320 


Asp Ile Arg Ser Ala Ile Asn Ser Leu Gln Phe Ser Ser Ser Lys Gly 
                325                 330                 335     


Glu Asn Asn Leu Arg Pro Arg Lys Lys Gly Met Ser Leu Lys Ser Asp 
            340                 345                 350         


Ala Val Leu Ser Lys Ser Lys Arg Arg Lys Lys Pro Asp Arg Val Phe 
        355                 360                 365             


Glu Asn Gln Glu Val Gln Ala Ile Gly Gly Lys Asp Val Ser Leu Phe 
    370                 375                 380                 


Leu Phe Arg Ala Leu Gly Lys Ile Leu Tyr Cys Lys Arg Ala Ser Leu 
385                 390                 395                 400 


Thr Glu Leu Asp Ser Pro Arg Leu Pro Ser His Leu Ser Glu Tyr Glu 
                405                 410                 415     


Arg Asp Thr Leu Leu Val Glu Pro Glu Glu Val Val Glu Met Ser His 
            420                 425                 430         


Met Pro Gly Asp Leu Phe Asn Leu Tyr Leu His Gln Asn Tyr Ile Asp 
        435                 440                 445             


Phe Phe Met Glu Ile Asp Asp Ile Val Arg Ala Ser Glu Phe Leu Ser 
    450                 455                 460                 


Phe Ala Asp Ile Leu Ser Gly Asp Trp Asn Thr Arg Ser Leu Leu Arg 
465                 470                 475                 480 


Glu Tyr Ser Thr Ser Ile Ala Thr Arg Gly Val Met His Ser Asn Lys 
                485                 490                 495     


Ala Arg Gly Tyr Ala His Cys Gln Gly Gly Gly Ser Ser Phe Arg Pro 
            500                 505                 510         


Leu His Lys Pro Gln Trp Phe Leu Ile Asn Lys Lys Tyr Arg Glu Asn 
        515                 520                 525             


Cys Leu Ala Ala Lys Ala Leu Phe Pro Asp Phe Cys Leu Pro Ala Leu 
    530                 535                 540                 


Cys Leu Gln Thr Gln Leu Leu Pro Tyr Leu Ala Leu Leu Thr Ile Pro 
545                 550                 555                 560 


Met Arg Asn Gln Ala Gln Ile Ser Phe Ile Gln Asp Ile Gly Arg Leu 
                565                 570                 575     


Pro Leu Lys Arg His Phe Gly Arg Leu Lys Met Glu Ala Leu Thr Asp 
            580                 585                 590         


Arg Glu His Gly Met Ile Asp Pro Asp Ser Gly Asp Glu Ala Gln Leu 
        595                 600                 605             


Asn Gly Gly His Ser Ala Glu Glu Ser Leu Gly Glu Pro Thr Gln Ala 
    610                 615                 620                 


Thr Val Pro Glu Thr Trp Ser Leu Pro Leu Ser Gln Asn Ser Ala Ser 
625                 630                 635                 640 


Glu Leu Pro Ala Ser Gln Pro Gln Pro Phe Ser Ala Gln Gly Asp Met 
                645                 650                 655     


Glu Glu Asn Ile Ile Ile Glu Asp Tyr Glu Ser Asp Gly Thr 
            660                 665                 670 


<210>  1003
<211>  2282
<212>  DNA
<213>  Homosapiens

<400>  1003
cagagtcctg ggcagcgtgc gcgctcttcc tggcggctgc gcaggtgtga aaatcacaaa     60

tgtcaaatga tggaagatcc aggaatcggg acaggcgcta cgatgaggtc ccaagcgacc    120

tgccctatca agataccacc ataagaaccc acccaattct tcatgacagt gagcgggcag    180

tgagcgctga tcccttgcca ccaccccctc tcccattaca gccaccattc ggcccagact    240

tctactcaag tgacacagaa gaaccagcta tagcgccaga tctcaaacca gtaaggcgct    300

ttgtccctga ctcctggaag aactttttca gagggaagaa aaaggacccc gaatgggata    360

agccggtgtc tgatatcagg tacatctccg atggagtgga gtgttcacca ccagcctctc    420

cagcaagacc aaaccaccgt tcgcccctca actcctgcaa agatccctac ggagggtcag    480

aaggaacctt tagttcccgg aaagaggctg acgcagtgtt tccccgggat ccctatggat    540

ctctagaccg acacacacaa acagttcgaa catacagtga gaaggtggag gagtataacc    600

tgagatactc ctacatgaag tcgtgggcag gcctgctgag aatactgggt gtggtggagc    660

tgcttttggg ggccggtgtc tttgcttgtg tcacagctta cattcacaag gacagtgagt    720

ggtacaactt gtttggatat tcacaaccgt atggcatggg aggcgttggt ggattgggca    780

gtatgtatgg gggctattac tacactggcc ctaagacccc ttttgtactc gtggttgctg    840

gattagcttg gatcaccacc attattattc tggttcttgg catgtccatg tattaccgga    900

ccattcttct ggactctaat tggtggcccc taactgaatt tggaattaac gttgccttgt    960

ttattttgta tatggccgca gccatagtct atgtgaatga taccaaccga ggtggcctct   1020

gctactatcc gttatttaat acaccagtga atgcagtgtt ctgccgggta gaaggaggac   1080

agatagctgc aatgatcttc ctgtttgtca ccatgatagt ttatctcatt agtgctttgg   1140

tttgcctaaa gttatggagg catgaggcag ctcggagaca tagagaatat atggaacaac   1200

aggagataaa tgagccatca ttgtcatcga aaaggaaaat gtgtgaaatg gccaccagtg   1260

gtgacagaca aagagactca gaagttaatt tcaaggaact gagaacagca aaaatgaaac   1320

ctgaactact gagtggacac atccccccag gccacattcc taaacctatc gtgatgcccg   1380

actatgtggc aaaataccct gtgattcaga cagatgatga gcgagaacgc tataaagctg   1440

tgttccaaga ccagttttca gagtacaaag agctgtctgc agaagttcag gctgtcctga   1500

ggaagtttga tgagctggat gcagtgatga gcagattgcc acatcattcg gaaagccgac   1560

aggaacatga gagaatttca agaatccatg aagagtttaa gaaaaaaaag aatgatccta   1620

catttctgga aaaaaaagaa cgctgtgatt acctaaagaa taaactttct cacataaagc   1680

aaagaattca agaatatgat aaagtaatga attgggatgt acaaggttat tcttaacgct   1740

tatttgaaac cactttattt ttttatttta ttttattttt ttgagatgaa gtctcgctct   1800

gttacccagg ctggaatgca gtggcacaat ctcggctcac tgcaacctcc acctcccggg   1860

ttcaagcaat tctcctgttc aagcaattag cctccccagt agctgggatt acaggcgtgc   1920

gctgccacac cccgctaatt tttgtatttt tagtagagac gaggtttcac catgttggtc   1980

aggctgggaa actacttttt ttaaaaaata gcaagtttac tatttattta ctgccttttt   2040

aatgctagcc tctgtggtag agaagcaagc gcttcccaaa tcagcttcca attggtttaa   2100

ccagtatgca acattaaaga ttttactcag acatctttaa acgaaaaaaa aaaaaaaaaa   2160

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2280

aa                                                                  2282


<210>  1004
<211>  558
<212>  PRT
<213>  Homosapiens

<400>  1004

Met Ser Asn Asp Gly Arg Ser Arg Asn Arg Asp Arg Arg Tyr Asp Glu 
1               5                   10                  15      


Val Pro Ser Asp Leu Pro Tyr Gln Asp Thr Thr Ile Arg Thr His Pro 
            20                  25                  30          


Ile Leu His Asp Ser Glu Arg Ala Val Ser Ala Asp Pro Leu Pro Pro 
        35                  40                  45              


Pro Pro Leu Pro Leu Gln Pro Pro Phe Gly Pro Asp Phe Tyr Ser Ser 
    50                  55                  60                  


Asp Thr Glu Glu Pro Ala Ile Ala Pro Asp Leu Lys Pro Val Arg Arg 
65                  70                  75                  80  


Phe Val Pro Asp Ser Trp Lys Asn Phe Phe Arg Gly Lys Lys Lys Asp 
                85                  90                  95      


Pro Glu Trp Asp Lys Pro Val Ser Asp Ile Arg Tyr Ile Ser Asp Gly 
            100                 105                 110         


Val Glu Cys Ser Pro Pro Ala Ser Pro Ala Arg Pro Asn His Arg Ser 
        115                 120                 125             


Pro Leu Asn Ser Cys Lys Asp Pro Tyr Gly Gly Ser Glu Gly Thr Phe 
    130                 135                 140                 


Ser Ser Arg Lys Glu Ala Asp Ala Val Phe Pro Arg Asp Pro Tyr Gly 
145                 150                 155                 160 


Ser Leu Asp Arg His Thr Gln Thr Val Arg Thr Tyr Ser Glu Lys Val 
                165                 170                 175     


Glu Glu Tyr Asn Leu Arg Tyr Ser Tyr Met Lys Ser Trp Ala Gly Leu 
            180                 185                 190         


Leu Arg Ile Leu Gly Val Val Glu Leu Leu Leu Gly Ala Gly Val Phe 
        195                 200                 205             


Ala Cys Val Thr Ala Tyr Ile His Lys Asp Ser Glu Trp Tyr Asn Leu 
    210                 215                 220                 


Phe Gly Tyr Ser Gln Pro Tyr Gly Met Gly Gly Val Gly Gly Leu Gly 
225                 230                 235                 240 


Ser Met Tyr Gly Gly Tyr Tyr Tyr Thr Gly Pro Lys Thr Pro Phe Val 
                245                 250                 255     


Leu Val Val Ala Gly Leu Ala Trp Ile Thr Thr Ile Ile Ile Leu Val 
            260                 265                 270         


Leu Gly Met Ser Met Tyr Tyr Arg Thr Ile Leu Leu Asp Ser Asn Trp 
        275                 280                 285             


Trp Pro Leu Thr Glu Phe Gly Ile Asn Val Ala Leu Phe Ile Leu Tyr 
    290                 295                 300                 


Met Ala Ala Ala Ile Val Tyr Val Asn Asp Thr Asn Arg Gly Gly Leu 
305                 310                 315                 320 


Cys Tyr Tyr Pro Leu Phe Asn Thr Pro Val Asn Ala Val Phe Cys Arg 
                325                 330                 335     


Val Glu Gly Gly Gln Ile Ala Ala Met Ile Phe Leu Phe Val Thr Met 
            340                 345                 350         


Ile Val Tyr Leu Ile Ser Ala Leu Val Cys Leu Lys Leu Trp Arg His 
        355                 360                 365             


Glu Ala Ala Arg Arg His Arg Glu Tyr Met Glu Gln Gln Glu Ile Asn 
    370                 375                 380                 


Glu Pro Ser Leu Ser Ser Lys Arg Lys Met Cys Glu Met Ala Thr Ser 
385                 390                 395                 400 


Gly Asp Arg Gln Arg Asp Ser Glu Val Asn Phe Lys Glu Leu Arg Thr 
                405                 410                 415     


Ala Lys Met Lys Pro Glu Leu Leu Ser Gly His Ile Pro Pro Gly His 
            420                 425                 430         


Ile Pro Lys Pro Ile Val Met Pro Asp Tyr Val Ala Lys Tyr Pro Val 
        435                 440                 445             


Ile Gln Thr Asp Asp Glu Arg Glu Arg Tyr Lys Ala Val Phe Gln Asp 
    450                 455                 460                 


Gln Phe Ser Glu Tyr Lys Glu Leu Ser Ala Glu Val Gln Ala Val Leu 
465                 470                 475                 480 


Arg Lys Phe Asp Glu Leu Asp Ala Val Met Ser Arg Leu Pro His His 
                485                 490                 495     


Ser Glu Ser Arg Gln Glu His Glu Arg Ile Ser Arg Ile His Glu Glu 
            500                 505                 510         


Phe Lys Lys Lys Lys Asn Asp Pro Thr Phe Leu Glu Lys Lys Glu Arg 
        515                 520                 525             


Cys Asp Tyr Leu Lys Asn Lys Leu Ser His Ile Lys Gln Arg Ile Gln 
    530                 535                 540                 


Glu Tyr Asp Lys Val Met Asn Trp Asp Val Gln Gly Tyr Ser 
545                 550                 555             


<210>  1005
<211>  2385
<212>  DNA
<213>  Homosapiens

<400>  1005
gataccggtt tcagagtcct gggcagcgtg cgcgctcttc ctggcggctg cgcaggtgtg     60

aaaatcacaa atgtcaaatg atggaagatc caggaatcgg gacaggcgct acgatgaggt    120

cccaagcgac ctgccctatc aagataccac cataagaacc cacccaattc ttcatgacag    180

tgagcgggca gtgagcgctg atcccttgcc accaccccct ctcccattac agccaccatt    240

cggcccagac ttctactcaa gtgacacaga agaaccagct atagcgccag atctcaaacc    300

agtaaggcgc tttgtccctg actcctggaa gaactttttc agagggaaga aaaaggaccc    360

cgaatgggat aagccggtgt ctgatatcag gtacatctcc gatggagtgg agtgttcacc    420

accagcctct ccagcaagac caaaccaccg ttcgcccctc aactcctgca aagatcccta    480

cggagggtca gaaggaacct ttagttcccg gaaagaggct gacgcagtgt ttccccggga    540

tccctatgga tctctagacc gacacacaca aacagttcga acatacagtg agaaggtgga    600

ggagtataac ctgagatact cctacatgaa gtcgtgggca ggcctgctga gaatactggg    660

tgtggtggag ctgcttttgg gggccggtgt ctttgcttgt gtcacagctt acattcacaa    720

ggacagtgag tggtacaact tgtttggata ttcacaaccg tatggcatgg gaggcgttgg    780

tggattgggc agtatgtatg ggggctatta ctacactggc cctaagaccc cttttgtact    840

cgtggttgct ggattagctt ggatcaccac cattattatt ctggttcttg gcatgtccat    900

gtattaccgg accattcttc tggactctaa ttggtggccc ctaactgaat ttggaattaa    960

cgttgccttg tttattttgt atatggccgc agccatagtc tatgtgaatg ataccaaccg   1020

aggtggcctc tgctactatc cgttatttaa tacaccagtg aatgcagtgt tctgccgggt   1080

agaaggagga cagatagctg caatgatctt cctgtttgtc accatgatag tttatctcat   1140

tagtgctttg gtttgcctaa agttatggag gcatgaggca gctcggagac atagagaata   1200

tatggaacaa caggagataa atgagccatc attgtcatcg aaaaggaaaa tgtgtgaaat   1260

ggccaccagt ggtgacagac aaagagactc agaagttaat ttcaaggaac tgagaacagc   1320

aaaaatgaaa cctgaactac tgagtggaca catcccccca cgcccagcta atttttttgt   1380

atttttagta gagatggggt ttcaccgtgt tagccaggat gatctcgatc tcctgacctc   1440

atgatccacc cgcctcagcc tcccaaagtg ttgggattac aggcgtgagt caccgcgccc   1500

agctggtatt gcttttctat tccctttgga catacatgct acagtcccac aatgtagcat   1560

ttccttggaa actccctttt tttttttttt tgagatggag tttcgctctt gttgcccagg   1620

ctggagtaca gtggtatgat cttggctcac tgcagcctct gcctcctggg ttcaagcgat   1680

tctcctgcct ctgcctccca agtagctggg attacaggca cccaccacca tgcccagcta   1740

attttttgta tttttagtag agacaggatt tcactatgtt ggccaggttg gtctcaagct   1800

cctgacctca gatgatctac cagcctcggc cttctgaagt gctgggattc aggtgtgagc   1860

cactgtgccc agcagggatg cttcatcttt ctaagaatta tcttggcttt ggactttatt   1920

cataaatgtt ttatttctgt tagtatgaac aatagactgc cttaacaaag ttttttttta   1980

aacaaaatcg ttcttgttgg attttattca gcagcatcta tcatgtagat aaattcccag   2040

gtgtagcatt acagcttctg actaatatag ctgccattca gacaattaat gttcaaagag   2100

ttttctaaag tgataaaacc aaagaaaagc atgtggaaaa gcagaagctt agaaagttgt   2160

ggtcactgaa tgcactccct ggtttttatt tgtcagtgaa atctttatgc attcattgtt   2220

aatattttaa ttccatggct ttgtaggctg tgctgtgtct gaaggggtaa cacctaggga   2280

aacatgaggc cccttatggg accccccaaa tggaacaact tcactttctc ttttatgtat   2340

tgagccctgt gttaacattt cacttaagaa gagcaccagt gcttt                   2385


<210>  1006
<211>  457
<212>  PRT
<213>  Homosapiens

<400>  1006

Met Ser Asn Asp Gly Arg Ser Arg Asn Arg Asp Arg Arg Tyr Asp Glu 
1               5                   10                  15      


Val Pro Ser Asp Leu Pro Tyr Gln Asp Thr Thr Ile Arg Thr His Pro 
            20                  25                  30          


Ile Leu His Asp Ser Glu Arg Ala Val Ser Ala Asp Pro Leu Pro Pro 
        35                  40                  45              


Pro Pro Leu Pro Leu Gln Pro Pro Phe Gly Pro Asp Phe Tyr Ser Ser 
    50                  55                  60                  


Asp Thr Glu Glu Pro Ala Ile Ala Pro Asp Leu Lys Pro Val Arg Arg 
65                  70                  75                  80  


Phe Val Pro Asp Ser Trp Lys Asn Phe Phe Arg Gly Lys Lys Lys Asp 
                85                  90                  95      


Pro Glu Trp Asp Lys Pro Val Ser Asp Ile Arg Tyr Ile Ser Asp Gly 
            100                 105                 110         


Val Glu Cys Ser Pro Pro Ala Ser Pro Ala Arg Pro Asn His Arg Ser 
        115                 120                 125             


Pro Leu Asn Ser Cys Lys Asp Pro Tyr Gly Gly Ser Glu Gly Thr Phe 
    130                 135                 140                 


Ser Ser Arg Lys Glu Ala Asp Ala Val Phe Pro Arg Asp Pro Tyr Gly 
145                 150                 155                 160 


Ser Leu Asp Arg His Thr Gln Thr Val Arg Thr Tyr Ser Glu Lys Val 
                165                 170                 175     


Glu Glu Tyr Asn Leu Arg Tyr Ser Tyr Met Lys Ser Trp Ala Gly Leu 
            180                 185                 190         


Leu Arg Ile Leu Gly Val Val Glu Leu Leu Leu Gly Ala Gly Val Phe 
        195                 200                 205             


Ala Cys Val Thr Ala Tyr Ile His Lys Asp Ser Glu Trp Tyr Asn Leu 
    210                 215                 220                 


Phe Gly Tyr Ser Gln Pro Tyr Gly Met Gly Gly Val Gly Gly Leu Gly 
225                 230                 235                 240 


Ser Met Tyr Gly Gly Tyr Tyr Tyr Thr Gly Pro Lys Thr Pro Phe Val 
                245                 250                 255     


Leu Val Val Ala Gly Leu Ala Trp Ile Thr Thr Ile Ile Ile Leu Val 
            260                 265                 270         


Leu Gly Met Ser Met Tyr Tyr Arg Thr Ile Leu Leu Asp Ser Asn Trp 
        275                 280                 285             


Trp Pro Leu Thr Glu Phe Gly Ile Asn Val Ala Leu Phe Ile Leu Tyr 
    290                 295                 300                 


Met Ala Ala Ala Ile Val Tyr Val Asn Asp Thr Asn Arg Gly Gly Leu 
305                 310                 315                 320 


Cys Tyr Tyr Pro Leu Phe Asn Thr Pro Val Asn Ala Val Phe Cys Arg 
                325                 330                 335     


Val Glu Gly Gly Gln Ile Ala Ala Met Ile Phe Leu Phe Val Thr Met 
            340                 345                 350         


Ile Val Tyr Leu Ile Ser Ala Leu Val Cys Leu Lys Leu Trp Arg His 
        355                 360                 365             


Glu Ala Ala Arg Arg His Arg Glu Tyr Met Glu Gln Gln Glu Ile Asn 
    370                 375                 380                 


Glu Pro Ser Leu Ser Ser Lys Arg Lys Met Cys Glu Met Ala Thr Ser 
385                 390                 395                 400 


Gly Asp Arg Gln Arg Asp Ser Glu Val Asn Phe Lys Glu Leu Arg Thr 
                405                 410                 415     


Ala Lys Met Lys Pro Glu Leu Leu Ser Gly His Ile Pro Pro Arg Pro 
            420                 425                 430         


Ala Asn Phe Phe Val Phe Leu Val Glu Met Gly Phe His Arg Val Ser 
        435                 440                 445             


Gln Asp Asp Leu Asp Leu Leu Thr Ser 
    450                 455         


<210>  1007
<211>  2648
<212>  DNA
<213>  Homosapiens

<400>  1007
gcctctctcc atcagacacc ccaaggttcc atccgaagca ggcggagcac cgaacgcacc     60

ccggggtggt cagggacccc catccgtgct gccccctagg agcccgcgcc tctcctctgc    120

gccccgcctc tcgggccgca acatcgcgcg gttcctttaa cagcgcgctg gcagggtgtg    180

ggaagcagga ccgcgtcctc ccgccccctc ccatccgagt ttcaggtgaa ttggtcaccg    240

agggaggagg ccgacacacc acacctacac tcccgcgtcc acctctccct ccctgcttcc    300

tctggcggag gcggcaggaa ccgagagcca ggtccagagc gccgaggagc cggtctagga    360

cgcagcagat tggtttatct tggaagctaa agggcattgc tcatcctgaa gatcagctga    420

ccattgacaa tcagccatgt catccaggcc tcttgaaagt ccacctcctt acaggcctga    480

tgaattcaaa ccgaatcatt atgcaccaag caatgacata tatggtggag agatgcatgt    540

tcgaccaatg ctctctcagc cagcctactc tttttaccca gaagatgaaa ttcttcactt    600

ctacaaatgg acctctcctc caggagtgat tcggatcctg tctatgctca ttattgtgat    660

gtgcattgcc atctttgcct gtgtggcctc cacgcttgcc tgggacagag gctatggaac    720

ttccctttta ggaggtagtg taggctaccc ttatggagga agtggctttg gtagctacgg    780

aagtggctat ggctatggct atggttatgg ctatggctac ggaggctata cagacccaag    840

agcagcaaag ggcttcatgt tggccatggc tgccttttgt ttcattgccg cgttggtgat    900

ctttgttacc agtgttataa gatctgaaat gtccagaaca agaagatact acttaagtgt    960

gataatagtg agtgctatcc tgggcatcat ggtgtttatt gccacaattg tctatataat   1020

gggagtgaac ccaactgctc agtcttctgg atctctatat ggttcacaaa tatatgccct   1080

ctgcaaccaa ttttatacac ctgcagctac tggactctac gtggatcagt atttgtatca   1140

ctactgtgtt gtggatcccc aggaggccat tgccattgta ctggggttca tgattattgt   1200

ggcttttgct ttaataattt tctttgctgt gaaaactcga agaaagatgg acaggtatga   1260

caagtccaat attttgtggg acaaggaaca catttatgat gagcagcccc ccaatgtcga   1320

ggagtgggtt aaaaatgtgt ctgcaggcac acaggacgtg ccttcacccc catctgacta   1380

tgtggaaaga gttgacagtc ccatggcata ctcttccaat ggcaaagtga atgacaagcg   1440

gttttatcca gagtcttcct ataaatccac gccggttcct gaagtggttc aggagcttcc   1500

attaacttcg cctgtggatg acttcaggca gcctcgttac agcagcggtg gtaactttga   1560

gacaccttca aaaagagcac ctgcaaaggg aagagcagga aggtcaaaga gaacagagca   1620

agatcactat gagacagact acacaactgg cggcgagtcc tgtgatgagc tggaggagga   1680

ctggatcagg gaatatccac ctatcacttc agatcaacaa agacaactgt acaagaggaa   1740

ttttgacact ggcctacagg aatacaagag cttacaatca gaacttgatg agatcaataa   1800

agaactctcc cgtttggata aagaattgga tgactataga gaagaaagtg aagagtacat   1860

ggctgctgct gatgaataca atagactgaa gcaagtgaag ggatctgcag attacaaaag   1920

taagaagaat cattgcaagc agttaaagag caaattgtca cacatcaaga agatggttgg   1980

agactatgat agacagaaaa catagaaggc tgatgccaag ttgtttgaga aattaagtat   2040

ctgacatctc tgcaatcttc tcagaaggca aatgactttg gaccataacc ccggaagcca   2100

aacctctgtg agcatcacaa agttttggtt gctttaacat catcagtatt gaagcatttt   2160

ataaatcgct tttgataatc aactgggctg aacactccaa ttaaggattt tatgctttaa   2220

acattggttc ttgtattaag aatgaaatac tgtttgaggt ttttaagcct taaaggaagg   2280

ttctggtgtg aactaaactt tcacacccca gacgatgtct tcatacctac atgtatttgt   2340

ttgcataggt gatctcattt aatcctctca accacctttc agataactgt tatttataat   2400

cacttttttc cacataagga aactgggttc ctgcaatgaa gtctctgaag tgaaactgct   2460

tgtttcctag cacacacttt tggttaagtc tgttttatga cttcattaat aataaattcc   2520

ctggcctttc atattttagc tactatatat gtgatgatct accagcctcc ctattttttt   2580

tctgttatat aaatggttaa aagaggtttt tcttaaataa taaagatcat gtaaaagtaa   2640

aaaaaaaa                                                            2648


<210>  1008
<211>  522
<212>  PRT
<213>  Homosapiens

<400>  1008

Met Ser Ser Arg Pro Leu Glu Ser Pro Pro Pro Tyr Arg Pro Asp Glu 
1               5                   10                  15      


Phe Lys Pro Asn His Tyr Ala Pro Ser Asn Asp Ile Tyr Gly Gly Glu 
            20                  25                  30          


Met His Val Arg Pro Met Leu Ser Gln Pro Ala Tyr Ser Phe Tyr Pro 
        35                  40                  45              


Glu Asp Glu Ile Leu His Phe Tyr Lys Trp Thr Ser Pro Pro Gly Val 
    50                  55                  60                  


Ile Arg Ile Leu Ser Met Leu Ile Ile Val Met Cys Ile Ala Ile Phe 
65                  70                  75                  80  


Ala Cys Val Ala Ser Thr Leu Ala Trp Asp Arg Gly Tyr Gly Thr Ser 
                85                  90                  95      


Leu Leu Gly Gly Ser Val Gly Tyr Pro Tyr Gly Gly Ser Gly Phe Gly 
            100                 105                 110         


Ser Tyr Gly Ser Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr 
        115                 120                 125             


Gly Gly Tyr Thr Asp Pro Arg Ala Ala Lys Gly Phe Met Leu Ala Met 
    130                 135                 140                 


Ala Ala Phe Cys Phe Ile Ala Ala Leu Val Ile Phe Val Thr Ser Val 
145                 150                 155                 160 


Ile Arg Ser Glu Met Ser Arg Thr Arg Arg Tyr Tyr Leu Ser Val Ile 
                165                 170                 175     


Ile Val Ser Ala Ile Leu Gly Ile Met Val Phe Ile Ala Thr Ile Val 
            180                 185                 190         


Tyr Ile Met Gly Val Asn Pro Thr Ala Gln Ser Ser Gly Ser Leu Tyr 
        195                 200                 205             


Gly Ser Gln Ile Tyr Ala Leu Cys Asn Gln Phe Tyr Thr Pro Ala Ala 
    210                 215                 220                 


Thr Gly Leu Tyr Val Asp Gln Tyr Leu Tyr His Tyr Cys Val Val Asp 
225                 230                 235                 240 


Pro Gln Glu Ala Ile Ala Ile Val Leu Gly Phe Met Ile Ile Val Ala 
                245                 250                 255     


Phe Ala Leu Ile Ile Phe Phe Ala Val Lys Thr Arg Arg Lys Met Asp 
            260                 265                 270         


Arg Tyr Asp Lys Ser Asn Ile Leu Trp Asp Lys Glu His Ile Tyr Asp 
        275                 280                 285             


Glu Gln Pro Pro Asn Val Glu Glu Trp Val Lys Asn Val Ser Ala Gly 
    290                 295                 300                 


Thr Gln Asp Val Pro Ser Pro Pro Ser Asp Tyr Val Glu Arg Val Asp 
305                 310                 315                 320 


Ser Pro Met Ala Tyr Ser Ser Asn Gly Lys Val Asn Asp Lys Arg Phe 
                325                 330                 335     


Tyr Pro Glu Ser Ser Tyr Lys Ser Thr Pro Val Pro Glu Val Val Gln 
            340                 345                 350         


Glu Leu Pro Leu Thr Ser Pro Val Asp Asp Phe Arg Gln Pro Arg Tyr 
        355                 360                 365             


Ser Ser Gly Gly Asn Phe Glu Thr Pro Ser Lys Arg Ala Pro Ala Lys 
    370                 375                 380                 


Gly Arg Ala Gly Arg Ser Lys Arg Thr Glu Gln Asp His Tyr Glu Thr 
385                 390                 395                 400 


Asp Tyr Thr Thr Gly Gly Glu Ser Cys Asp Glu Leu Glu Glu Asp Trp 
                405                 410                 415     


Ile Arg Glu Tyr Pro Pro Ile Thr Ser Asp Gln Gln Arg Gln Leu Tyr 
            420                 425                 430         


Lys Arg Asn Phe Asp Thr Gly Leu Gln Glu Tyr Lys Ser Leu Gln Ser 
        435                 440                 445             


Glu Leu Asp Glu Ile Asn Lys Glu Leu Ser Arg Leu Asp Lys Glu Leu 
    450                 455                 460                 


Asp Asp Tyr Arg Glu Glu Ser Glu Glu Tyr Met Ala Ala Ala Asp Glu 
465                 470                 475                 480 


Tyr Asn Arg Leu Lys Gln Val Lys Gly Ser Ala Asp Tyr Lys Ser Lys 
                485                 490                 495     


Lys Asn His Cys Lys Gln Leu Lys Ser Lys Leu Ser His Ile Lys Lys 
            500                 505                 510         


Met Val Gly Asp Tyr Asp Arg Gln Lys Thr 
        515                 520         


<210>  1009
<211>  6748
<212>  DNA
<213>  Homosapiens

<400>  1009
ttatatggtt tggctctgtc cgcacccaaa tctcatcttg aattgtaaca attcccatgt     60

gtcaagggtg gggccaggtg gagataactg aatcatggag gcagtttccc ccatgctgtt    120

ctcatggtag tgaataagtc tcatgaggtc tgatggtttt ataaatggat gttcccctgc    180

acatgctctc tcctgcccac catgtctgac taaattttgt atttttacta gagacgggct    240

ttcactatgt tggccaggct ggcctccaac tcctgatctc gtgatccgtc caccccgacc    300

tcccaaagtg ctaggatcat aggcataagc caccacaccc ggcctctttt ttttcttttt    360

ctttttttta tctggagact gagttttgca ctcgttgccc aggctggagt gcaatggtgc    420

gatctcagct cactgcagtc tccacctcag caggagagca ggaatcttca gtgatccacg    480

ggcaaatatg cagccattgt gggcacctgt tcctcccgcg acctttgtgc ccacgtctct    540

ccctccagta cctactgcac gaccccccac gtccgcctcc tgccattgcc agcaggtgcc    600

ttgcgcgggt acctggctgc gcttattcat ccattatggt cgctctgtca ctggtgccat    660

tatgtgctca catgcccact ccctcaggtt tagaagtcgc gttgcccggc aacagaacaa    720

tctgctggct tagcctttgg ccaagttggc agctggacga ggacgctcag agcccagctc    780

ttgagagttc aagtatccga cagttcccca ctgctcccag gagcggttac ccgggcactc    840

tgtgcccctc attcctgttt gggccaaggc cgaggacctg cgagtagggc tcagttgcct    900

ggagcccctt cagcccatcc cccagttcac tttgcttgtg ggatctcccc gttgctcctg    960

cccctggact gagtggcagg ccatcctaca aacacccgca cactcgacat cagtggtgtc   1020

aagacaactc taagaaggtt ttccgtgatc ctgcaagacc tgtgttccat cctggtgatt   1080

ctgtcttcaa cttcactgca caggtaccac agtaagccag tgctgtgtgc tctgagttcc   1140

agggcatccc ccagctcagc cactacactg agcacaagga ctctgtgggg cccaggagca   1200

ggtagtcacc cctttggggt ccacaacacc cggctgtccc cagacttgtg tccagggaag   1260

atagtgttga gggccctcaa ggagagcggg gcagggatgc ctgagcagca caaggacccc   1320

agagtccaag aaaatcctga tgatcagaga acggtccccg aggtcaccgg ggatgcacgg   1380

tctgcatttt ggcccctgcg ggacaatgga ggcccctctc cctttgtgcc caggcccggg   1440

cctctgcaga cagacctcca cgcccagagc tcagaaatca gatataacca cacatcccag   1500

acatcctgga cgagctcgag caccaaacga aatgccatct ccagctccta cagctccacg   1560

ggaggcttgc cggggctaaa gcagaggagg gggccagcct catcccgctg ccagctgacc   1620

ctcagttact caaagacagt gagtgaggac aggcctcagg ctgtctcttc gggtcacaca   1680

cggtgtgaaa agggggcaga tacagcacca gggcagacaa tcgccccaac gggtggctcc   1740

cccagatccc aggactctag gccccgtaga cgcaagattc ccctgctgcc acgcaggcga   1800

ggggagcctt tgatgctgcc acctccctta gagctggggt accgggtcac ggctgaagac   1860

ctgcacctgg aaaaagagaa ggcattccag cgcatcaaca gtgcactgca cgttgaggac   1920

aaggccatct cggactgcag accctcacgg ccttcccaca ctttgtcctc acttgcaaca   1980

ggggcttcgg gtgggcctcc cgtttctaaa gcacccacta tggatgcaca gcaggacaga   2040

cccaagtccc aagactgcct gggcctagtg gcccccctag catctgcagc agaggtcccc   2100

gctacagctc ccgtgtctgg gaagaagcac agaccaccag gacccctgtt ctcctcctca   2160

gatccccttc cggccaactc ttcccactcc cgggactcag cccaggtcac ctcgatgatt   2220

cctgtcccct tgacagctgc aagcagggat gccggcatga gaagaacaag gtcggctcct   2280

gcagctgccg cagcagcccc tcccccctcc acattgaacc ccacgtcggg gtcactactc   2340

aatgcagtgg atggaggccc ctcacatttc ttggcctcag ccacagctgc agcacgtgtc   2400

cagaggtcag aagtgagata taaccagaga tcccagacct cccggaccag atcgtgcctc   2460

aaacgaaatg ccagctccag ctcccacagc tctacggaag gcctccagga agtaaagcgg   2520

aggagggggc cagcctcatc ccactgccag ctggcccaca gttcctcaaa cacagtgagt   2580

gaggatggac ctcaggctgt ctcttcgggt caccgctgtg aaaacaaggc aggtacagca   2640

ccagggcaga cacttgcccc caggggtggc tcccccagat cccaggcctc taggccccac   2700

atcaacactg cactgcacgt tgaggacaag gccatctcgg actgcagacc ctcacgacct   2760

tcccacactt tgtcctcact tgcaacagag gcttcgggtg ggcctcccgt ttctaaagca   2820

cccactatgg acgcacagca ggacagaccc aagtcccaag actgcctggg cctagtggcc   2880

cccctagcat ctgctgcaga ggtcccctct acagctcccg tgtctgggaa gaagcacaga   2940

ccaccaggac ccctgttctc ctcctcagat ccccttcctg ccacctcttc ccactcccgg   3000

gactcagccc aggtcacctc gctgattcct gccaccttca cagctgcaag cagggatgcc   3060

ggcatgagaa gaacaaggtc ggctcctgca gctgccgcag cagcccctcc cccctccaca   3120

ttgaacaaca cgtcggggtc actactcaat gcagtggatg gaggcccctc acatttcttg   3180

gcctcagcca cagctgcagc acgtgcccag aggtcagaag tgagatataa ccagagatcc   3240

cagacctccc ggaccagatc ctgcctcaaa cgaaatgcca gctccagctc cagctcccac   3300

agctctacgg aaggcctcca ggaactaaag cggaggaggg ggccagcctc atcccactgc   3360

cagctggccc acagttcccc aaacacagtg agtgaggacg gacctcaggc tgtctcttcg   3420

ggtcaccgct gtgaaaacaa ggcaggtaca gcaccagggc agacactcgc ccccagggga   3480

ggctccccca gatcccaggc ctctaggccc cacatcaaca gtgcactgca cgttgaggac   3540

aaggccatct cggactgcag accctcacgg ccttcccaca ctttgtcctc acttgcaaca   3600

ggggcttcgg gtgggcctcc cgtttctaaa gcacccacta tggacgcaca gcaggacaga   3660

cccaagtccc aagactgcct gggcctagtg gcccccctag catctgctga agaggtcccc   3720

tctacagctc ccgtgtctgg gaagaagcac agaccaccag gacccctgtt ctcctcctca   3780

gatccccttc ctgccacctc ttcccactcc cgggactcag cccaggtcac ctcgctgatt   3840

cctgccacct tcacagctgc aagcagggat gccggcatga gaagaacaag gcctggcacc   3900

tcggctcctg cagctgccgc agcagccctt cccccctcca cattgaaccc cacgtcgggg   3960

tcgctactca atgcagtgga tggaggcccc tcacatttct tggcctcagc cacagctgca   4020

gcacgtgccc agaggtcaga agtgagatat aaccagagat cccagacctc ccggaccaga   4080

tcctgcctca aacgaaatgc cagctccagc tcccacagct ctacggaagg cctccaggaa   4140

gtaaagcgga ggagggggcc agcctcatcc cactgccagc tggcccacag ttcctcaaac   4200

acagtgagtg aggacggacc tcaggctgtc tcttcgggtc accgctgtga aaacaaggca   4260

ggtacagcac cagggcagac acttgccccc aggggtggct cccccagatc ccaggcctct   4320

aggccccgca tcaacactgc actgcacgtt gaggacaagg ccatctcgga ctgcagaccc   4380

tcacggcctt cccacacttt gtcctcactt gcaacagggg cttcgggtgg gcctcccgtt   4440

tctaaagcac ccactatgga tgcacagcag gacagaccca agtcccaaga ctgcctgggc   4500

ctactggccc ccctagcatc tgctgcagag gtctcctcta cagctcccat gtctgggaag   4560

aagcacagac caccaggacc cctgttctcc tcctcagatc cccttcctgc cacctcttcc   4620

cactccgggg actcagccca ggacacctcg ctgattcctg cccccttcac acctgcaagc   4680

agggatgccg gcatcagaag aatgtttcgt gttcgaaatt gtttgagggg tttgggttta   4740

tttttgttgg ttttttcttt tttttttttg cttacgtggg catccttcag cttttaataa   4800

tctgaaaaat tgtatttacc cattgtcaat gtgtataaat taatctcagt caattttata   4860

caataaaagg tgaactttta tccatcaaac aataatttaa caaaaaatgt accggaagaa   4920

gaatgttcat tacaaatata ggaaacataa atattaccaa atattggcaa gcactaaaat   4980

gttcagaaat ataagtctat tacagttata gctctctcaa gcaaaaaaac agcagagaaa   5040

aacttagttt tcctgagggg ctatttattt acttagggat ttgttaaaag gtcaaatggg   5100

gtcacacaga atactaagaa gagctgttca cccaggcctc actaagaact cttcttcatg   5160

cagtagctat ataggaatat gacaactgct cctacgaccc aaagaggaac tacagcaact   5220

actctttagc atctgttgct cccaactctg ctttgcaatt atatgactca agcattctgg   5280

ctccgttaac tattactgct gttactccca agtaaattcc ctctaaaaaa taaaaatttt   5340

taaagctgta atttaagctc tctgctgcct catgacttca attccatcag agttacgcat   5400

tgtttcctct gtacatcttt gctctgcttc cattgctaat tccctagtaa agtgttgtat   5460

attcaaagtt ccaaagaaac agaatatcca agacatcacc aatcatccaa aacacagtgt   5520

aggaggccac agttaagaga agcaagacca ttagctcttt ttataggctc gagaacaaca   5580

ggatgctttg gtcctgtatc agcaggacgc tttttgggta gatcctactg ccaccctact   5640

atcgggtaga tcctactgtc accctagcta tgggcacatg tcagagtccc atgtaataaa   5700

ggagacaaaa ggaaaccacc acgagtataa actaagaaaa gtactccaag gtttctaaga   5760

atggagctgt ataactcact ttgccccgtt tgttacttct ccacggtact taccaccacc   5820

tattacatat attttgttta tagtcagtct tcccccatta gaatgaaagt tccgtgagga   5880

taggactata cagtcagccc tcagtatcca tgggggactg gtttcaggat ctcctgaggg   5940

taacaaagga tactcaagtc cctgatataa aatgacatag tatttgcaca tcacctttgc   6000

acatcctccc atatacttca tatcaactct agatcactca taatatccga tgtaaatgtc   6060

atgcaaatag ttattgtact atattgtgta aggaataagg acaagaaaaa agtctgtaca   6120

tgttcagtac agacgcaatt tttttttcca atatttccaa tccttggttg ccttaacgga   6180

tgtagaaccc aggaataagt tctggtgtcc tattgcatag taggatgagt atagttaaca   6240

ataacatatt atatatttga aaatagccag aagagtagat tttgaatttt ctccctacag   6300

aaaaatcatt atgcaaatta ccctgatttg atcattacac attgagtaca tgtattaaaa   6360

catcacattc taccccatat atatgtacag ttattatgtg tccataaaaa tttaatgtca   6420

atgtgtgaaa taaaatgaaa aaataaaaat ttttaaagct gtaattatct ccatctggta   6480

ggaatatata caatctgaaa taaaaaatat atttgtaatt gttaggacaa aatagattat   6540

acattaagtc tgcaaattat aaattataaa attctcacag aacctgaaaa attattgata   6600

ctgttaaata tttaaaaagc tgtccttgga gagaaagaaa cctatcagat ttacatcaac   6660

aagtgtaata tgtcagccta ttaccatctg ctacagactg catgtttgtg ttccctcaaa   6720

attcatatga taggcccggc gcggtggc                                      6748


<210>  1010
<211>  1166
<212>  PRT
<213>  Homosapiens

<400>  1010

Met Pro Glu Gln His Lys Asp Pro Arg Val Gln Glu Asn Pro Asp Asp 
1               5                   10                  15      


Gln Arg Thr Val Pro Glu Val Thr Gly Asp Ala Arg Ser Ala Phe Trp 
            20                  25                  30          


Pro Leu Arg Asp Asn Gly Gly Pro Ser Pro Phe Val Pro Arg Pro Gly 
        35                  40                  45              


Pro Leu Gln Thr Asp Leu His Ala Gln Ser Ser Glu Ile Arg Tyr Asn 
    50                  55                  60                  


His Thr Ser Gln Thr Ser Trp Thr Ser Ser Ser Thr Lys Arg Asn Ala 
65                  70                  75                  80  


Ile Ser Ser Ser Tyr Ser Ser Thr Gly Gly Leu Pro Gly Leu Lys Gln 
                85                  90                  95      


Arg Arg Gly Pro Ala Ser Ser Arg Cys Gln Leu Thr Leu Ser Tyr Ser 
            100                 105                 110         


Lys Thr Val Ser Glu Asp Arg Pro Gln Ala Val Ser Ser Gly His Thr 
        115                 120                 125             


Arg Cys Glu Lys Gly Ala Asp Thr Ala Pro Gly Gln Thr Ile Ala Pro 
    130                 135                 140                 


Thr Gly Gly Ser Pro Arg Ser Gln Asp Ser Arg Pro Arg Arg Arg Lys 
145                 150                 155                 160 


Ile Pro Leu Leu Pro Arg Arg Arg Gly Glu Pro Leu Met Leu Pro Pro 
                165                 170                 175     


Pro Leu Glu Leu Gly Tyr Arg Val Thr Ala Glu Asp Leu His Leu Glu 
            180                 185                 190         


Lys Glu Lys Ala Phe Gln Arg Ile Asn Ser Ala Leu His Val Glu Asp 
        195                 200                 205             


Lys Ala Ile Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser 
    210                 215                 220                 


Ser Leu Ala Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro 
225                 230                 235                 240 


Thr Met Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly 
                245                 250                 255     


Leu Val Ala Pro Leu Ala Ser Ala Ala Glu Val Pro Ala Thr Ala Pro 
            260                 265                 270         


Val Ser Gly Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser 
        275                 280                 285             


Asp Pro Leu Pro Ala Asn Ser Ser His Ser Arg Asp Ser Ala Gln Val 
    290                 295                 300                 


Thr Ser Met Ile Pro Val Pro Leu Thr Ala Ala Ser Arg Asp Ala Gly 
305                 310                 315                 320 


Met Arg Arg Thr Arg Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro 
                325                 330                 335     


Pro Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp 
            340                 345                 350         


Gly Gly Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Val 
        355                 360                 365             


Gln Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr 
    370                 375                 380                 


Arg Ser Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr 
385                 390                 395                 400 


Glu Gly Leu Gln Glu Val Lys Arg Arg Arg Gly Pro Ala Ser Ser His 
                405                 410                 415     


Cys Gln Leu Ala His Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro 
            420                 425                 430         


Gln Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala 
        435                 440                 445             


Pro Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala 
    450                 455                 460                 


Ser Arg Pro His Ile Asn Thr Ala Leu His Val Glu Asp Lys Ala Ile 
465                 470                 475                 480 


Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala 
                485                 490                 495     


Thr Glu Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp 
            500                 505                 510         


Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly Leu Val Ala 
        515                 520                 525             


Pro Leu Ala Ser Ala Ala Glu Val Pro Ser Thr Ala Pro Val Ser Gly 
    530                 535                 540                 


Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu 
545                 550                 555                 560 


Pro Ala Thr Ser Ser His Ser Arg Asp Ser Ala Gln Val Thr Ser Leu 
                565                 570                 575     


Ile Pro Ala Thr Phe Thr Ala Ala Ser Arg Asp Ala Gly Met Arg Arg 
            580                 585                 590         


Thr Arg Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro Pro Ser Thr 
        595                 600                 605             


Leu Asn Asn Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Gly Gly Pro 
    610                 615                 620                 


Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala Gln Arg Ser 
625                 630                 635                 640 


Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg Ser Cys 
                645                 650                 655     


Leu Lys Arg Asn Ala Ser Ser Ser Ser Ser Ser His Ser Ser Thr Glu 
            660                 665                 670         


Gly Leu Gln Glu Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser His Cys 
        675                 680                 685             


Gln Leu Ala His Ser Ser Pro Asn Thr Val Ser Glu Asp Gly Pro Gln 
    690                 695                 700                 


Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala Pro 
705                 710                 715                 720 


Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala Ser 
                725                 730                 735     


Arg Pro His Ile Asn Ser Ala Leu His Val Glu Asp Lys Ala Ile Ser 
            740                 745                 750         


Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala Thr 
        755                 760                 765             


Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp Ala 
    770                 775                 780                 


Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly Leu Val Ala Pro 
785                 790                 795                 800 


Leu Ala Ser Ala Glu Glu Val Pro Ser Thr Ala Pro Val Ser Gly Lys 
                805                 810                 815     


Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu Pro 
            820                 825                 830         


Ala Thr Ser Ser His Ser Arg Asp Ser Ala Gln Val Thr Ser Leu Ile 
        835                 840                 845             


Pro Ala Thr Phe Thr Ala Ala Ser Arg Asp Ala Gly Met Arg Arg Thr 
    850                 855                 860                 


Arg Pro Gly Thr Ser Ala Pro Ala Ala Ala Ala Ala Ala Leu Pro Pro 
865                 870                 875                 880 


Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Gly 
                885                 890                 895     


Gly Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala Gln 
            900                 905                 910         


Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg 
        915                 920                 925             


Ser Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr Glu 
    930                 935                 940                 


Gly Leu Gln Glu Val Lys Arg Arg Arg Gly Pro Ala Ser Ser His Cys 
945                 950                 955                 960 


Gln Leu Ala His Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro Gln 
                965                 970                 975     


Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala Pro 
            980                 985                 990         


Gly Gln Thr Leu Ala Pro Arg Gly  Gly Ser Pro Arg Ser  Gln Ala Ser 
        995                 1000                 1005             


Arg Pro  Arg Ile Asn Thr Ala  Leu His Val Glu Asp  Lys Ala Ile 
    1010                 1015                 1020             


Ser Asp  Cys Arg Pro Ser Arg  Pro Ser His Thr Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ala Thr  Gly Ala Ser Gly Gly  Pro Pro Val Ser Lys  Ala Pro Thr 
    1040                 1045                 1050             


Met Asp  Ala Gln Gln Asp Arg  Pro Lys Ser Gln Asp  Cys Leu Gly 
    1055                 1060                 1065             


Leu Leu  Ala Pro Leu Ala Ser  Ala Ala Glu Val Ser  Ser Thr Ala 
    1070                 1075                 1080             


Pro Met  Ser Gly Lys Lys His  Arg Pro Pro Gly Pro  Leu Phe Ser 
    1085                 1090                 1095             


Ser Ser  Asp Pro Leu Pro Ala  Thr Ser Ser His Ser  Gly Asp Ser 
    1100                 1105                 1110             


Ala Gln  Asp Thr Ser Leu Ile  Pro Ala Pro Phe Thr  Pro Ala Ser 
    1115                 1120                 1125             


Arg Asp  Ala Gly Ile Arg Arg  Met Phe Arg Val Arg  Asn Cys Leu 
    1130                 1135                 1140             


Arg Gly  Leu Gly Leu Phe Leu  Leu Val Phe Ser Phe  Phe Phe Leu 
    1145                 1150                 1155             


Leu Thr  Trp Ala Ser Phe Ser  Phe 
    1160                 1165     


<210>  1011
<211>  5763
<212>  DNA
<213>  Homosapiens

<400>  1011
gcgcaaggca cctgctggca atggcaggag gcggacgtgg ggggtcgtgc agtaggtact     60

ggagggagag acgtgggcac aaaggtcgcg ggaggaacag gtgcccacaa tggctgcata    120

tttgcccgtg gatcactgaa gattcctgct ctcctgctga ggtggagact gcagtgagct    180

gagatcgcac cattgcactc cagcctgggc aacgagtgca aaactcagtc tccagataaa    240

aaaaagaaaa agaaaaaaaa gaggccgggt gtggtggctt atgcctatga tcctagcact    300

ttgggaggtc ggggtggacg gatcacgaga tcaggagttg gaggccagcc tggccaacat    360

agtgaaagcc cgtctctagt aaaaatacaa aatttagtca gacatggtgg gcaggagaga    420

gcatgtgcag gggaacatcc atttataaaa ccatcagacc tcatgagact tattcactac    480

catgagaaca gcatggggga aactgcctcc atgattcagt tatctccacc tggccccacc    540

cttgacacat gggaattgtt acaattcaag atgagatttg ggtgcggaca gagccaaacc    600

atataattct tccccggccc ctcccaaatc tcatgtcctc atatttcaaa agcaatcatg    660

ccttccccta agtcccccaa actcttattt cagcattaac tcaaaattcc atagtccaaa    720

gtctcatctg agacaaggca agtcccttcc acctatgagc ctgtaaaatc aaaagcaagt    780

tagttatttt ctagatacac agggatacag gcattgggta aatacactcg tttcaaatgg    840

gagaaattgg ccaaagcgaa agagctacag gccccatgca agtccaaaac ccagcaggca    900

aatcttaaag ctccaaaatg acctcctttg actccatgtg tcacatctag gtgatgcaag    960

aagtgggttc ccagggtctt gggcagcccc gcccctgtgg ctttgcaggg tacagccccc   1020

cttctggctg cattgagtgt ctgcagcttt tccaggcaca cagtgcaagc tgtcagtgga   1080

tctaccattc tggggtctgg aggatggtgg cccttttctc acagctctgc ttggcagtac   1140

cccagtgggg actctgtgtg ggagctccaa ccccatattt ccctttgaca ctgtcctagc   1200

agaggttatc catgagggcc cccccctccc ctccccccca cagcaaactt ttgcctggat   1260

ttccaggcat tttcatacat cttctgaaat gtaggcggag gttcatgaac gttaattctt   1320

gactttggtg catctgcagg cttaacacca cctagaacct gaaaggcttg gaacttgcac   1380

cctctgaagc catggcctga ggtgtacctt ggcccctttt acctatggca ggagcagctg   1440

ggatgcaggg ccccaagttc ctaggctgca cacagcaggg ggttctggac ccacaaaacc   1500

atttttcctt ctaagcctcc tggcctgtga tgggagggtc tgctgtgagg gtctctaaca   1560

tgccctggag acatttgccc cattgtcttg gtgattaaca tttggctcct cattacttat   1620

gcaaatttct acaacccagt ctcctgagaa aatagatttt tcttttctgt tgcatcatca   1680

ggctacaaat tttctgaact tttatgctct gcttcttctc gaatgctttg ctgcttagaa   1740

atttcttctg tcagatacct tcaatcatct ctctcaagtt caaagttcca cagatctgta   1800

gggaactcta gaaagaaatt cttattttcc ctctttcccg cctatcttat gcccgtttct   1860

aatacaggtg cacaatgcct gcagtgtctt tgcatagtaa gagtgacttt actccatttc   1920

ccaacaaatt cctcatctcc ctctgagacc acctccgcct ggaccttgtt gtccatatca   1980

ctattaacat tttggtcaaa gccattcaac aagtctctag gaagttccaa actttcccac   2040

attttcctat cctcttctga gccttccaaa ctgttccagc ctctccctgt tacccatttc   2100

caaagttgct tccacatttt cgggtatctt tacagcagca ccccactcta ctggtatcaa   2160

cttattgtat tagtctgttc tcacaccgca aataaagaca tacctgagac tgggtaattt   2220

ataaaggaaa gaggttgaat tgactcacag ttctgcatgg ctggggaggc ctcacaatca   2280

tggtggaagg caaggaggtg caaaagcatg tctcacatag tggcaggcag gagagagcat   2340

gtgcagggga gctcccattt ataaaaccat cagatctcat gagacttagt cactaccgcg   2400

agaacagtat ggggggaacc atccccatga ttcagttatc tgcacccggc cccacccttg   2460

acacgtggga attattacaa tgcaagggct ggtgaattac cagatctccg tcaagtgcag   2520

taaccagttc aagttggaag tgtgtctttt gaatgcagaa aacaaagtcg tggacaacca   2580

ggctgggacc cagggccagc tgaaggtgct gggtgccaac ctctggtggc cgtacctgat   2640

gcacgaacac cccgcctacc tgtactcgtg ggaggatggt gattgctcac accaaagcct   2700

tggacccctc ccagcctgtg acctttgtga ccaactccac ctacgcagca gacaaggggg   2760

ctctgtatgt ggatgtgatc cgtgtgaaca gctactactc ttggtatcgc aactacgggc   2820

acctggagtt gattcagctg cagctggccg cccagtttga gaattggtgt aagacatcac   2880

aatcccatta ttcagagcgc gtatggagtg gaaacgcttg tagggtttca ccaggatcca   2940

cctctgatgt tcagtgaaga ggaccggaaa agtctgctag agcagtacca tctgggtctg   3000

gatcaaaaac gcagaaaata cgtggttgga gagctcatct ggaattttgc cgatttcatg   3060

actaaccagt ccaaggatga aggaaaaact ggacctcatt atggatttac ttttgggata   3120

cactcattat tccagaggag ggtaaaaggc tgagaagctt aagacttgct ataattctgt   3180

gagagagcta taaaagtctg ctcagaaaca ttataacgta aaatggacag agaaggacaa   3240

tgagatattt aatttgccac ggcaaagcca ttgctgtgaa gaatggataa tatatgtcaa   3300

tggtaatata tgaagaaata acacagatgg agctggcttg aaatcctctt gtttatggca   3360

gtacatatcg tttatgattc aaaaaatata gcccatttcc aaaaacctgc aacaaagaga   3420

tactttctca ggtgtcagtt tcttggtcgg gaatgaaaat agtgccaacc tgtgatacct   3480

tcactctaat tttactttct gaggaagttt tctgtaatag ttatttggtg ataattatta   3540

atactggtga gaaaatcaat gtaaaagagg agaaataacc cacacaacca catacaacta   3600

ggaaatgata gatggatctg aaaaaaaagg atatgcactc ttaacaagtt caacacccaa   3660

gtactattgc aagtaccagc tgtatttcat ggaaaaaaaa aaaagaataa ctcaaaaggc   3720

agaacgaaga gcctagaggt cagagatgag aggcatgaat aattattcac aggcgttgaa   3780

tataatcaaa tgacttgcaa catttaccac tgggatttta aaatgtggtg gaccaatcat   3840

tcttttagtc tgtgcatttt cccatttttt tcaacaggaa tgtctagaga cattattcct   3900

gttttgccac tgtatttttg gtgaatgtgt agtaagtaac tggcctcttt agtatcacaa   3960

agctggatga agaaaatgtg gtacatatac accatgaaat actatgccgc cacaaaaagg   4020

aaatgagatc atgtcctctg cagggacatg gatgaagctg gaagccatta tccttagcaa   4080

agtaacgcag gaacagaaaa ccaaacacca catgttgtct cttagaagtg ggagctgaac   4140

gatgggcttt gcagagatta aagcttcaga aaaaaatatg ggaaaatatg ttaaaatgtt   4200

gacctgaaaa tgaagtggat gactataaaa ctcttgagag aattagactt tttgtagcag   4260

tttattacat gataatacct taaaggagat cacattcagt gacctgcgtt gacagatgtg   4320

aatttcttcg gagtaagaaa tcctcagagg aaattaccca gtatattcaa agctacaagg   4380

gatttgttga cataacggta atgtataaca gcaatttttt tctcaagttt ttggattacc   4440

tgtaagtgtc tgactcagaa gggcataggc attcttttta tgtcatgggt ttgatttctt   4500

tcttcctttc tcctttcatt cccctggctc ccatcttcaa agtgaaaaat atcacattca   4560

cttgctgacc tagagccttt ttctttttcc agggctggct tctgacgggc tctgcttgcc   4620

ttcctgatag tcttcccctt tatgaatgaa gccacttgcc ccagcttccc tctgctgccc   4680

ctatctgcag gcttgctaag atctcctgac ctaggcgctg tcacccacag tgggctgcag   4740

agctggctct tcctagctgg ctaactatcc tgaatcagta aaaatttcct agtggagagt   4800

gatgggaaat cgaatccaaa ctggcttaaa caaaaatgag aatttattga ttaacatgac   4860

tcaggagacc agaactctat agagaacatg gcctgacagt gggggaagag aggtgtttcc   4920

tcaaaaagaa actgggtgca gctttcccag aagaatcagt tgctcaatat ataataccct   4980

gatgaattta gttaccattc tatgtctctt acttcctcat tcgtcaaagt acatctgtga   5040

tatttaaatg caggtctgtt ttcaaggtca gtttccggaa acagtgaccc tgagaaggct   5100

tcctcctgag tatgcataaa cattcacagc ttgcatgcgt gtgtgtgtgt gtgtgtgtgt   5160

gtgtgtgtat gtttgcttgc actgcataaa aacaattgca acatcaacag aaataaaaat   5220

taaaggaata attctcctcc gactctgccg ttccatccag tgaaactctt cattctgggg   5280

taaagttcct tcagttcttg ttcatagata ggtatatact tcataagtca aacaatcagg   5340

ctgggcgcag tagctcatgc ctgtaatccc agccctttgg gaggccgagc tgggcagatc   5400

acttgagatc aggtgttcga gaccagcctc aagacctcca acatgggccg ggtgcagtgg   5460

ctcacgtctg taatcccagc actttgggag gccgagacgg acggatgatg aggtcaggag   5520

atagagacca tcctggctaa catggtgaaa ccccatctct actaaaaata caaaaaaaaa   5580

aaaaaattag cccggcatgg tggcaggcgc ctgtggtccc agctactcgg gaggctgagg   5640

caggagaatg gcgtgaacct gggaggcaga gcttgtagtg agccaagtgc cactgtgctc   5700

cagcctggac gacagagcga gactctgtct caaaaaaaaa aaaaaagaaa aaaaaaaaaa   5760

aaa                                                                 5763


<210>  1012
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  1012

Met Val Ile Ala His Thr Lys Ala Leu Asp Pro Ser Gln Pro Val Thr 
1               5                   10                  15      


Phe Val Thr Asn Ser Thr Tyr Ala Ala Asp Lys Gly Ala Leu Tyr Val 
            20                  25                  30          


Asp Val Ile Arg Val Asn Ser Tyr Tyr Ser Trp Tyr Arg Asn Tyr Gly 
        35                  40                  45              


His Leu Glu Leu Ile Gln Leu Gln Leu Ala Ala Gln Phe Glu Asn Trp 
    50                  55                  60                  


Cys Lys Thr Ser Gln Ser His Tyr Ser Glu Arg Val Trp Ser Gly Asn 
65                  70                  75                  80  


Ala Cys Arg Val Ser Pro Gly Ser Thr Ser Asp Val Gln 
                85                  90              


<210>  1013
<211>  1912
<212>  DNA
<213>  Homosapiens

<400>  1013
ccggcggctg ttgtcgggcc tccagcgggc ggggccgttg gcggagcaga gcggaggcgc     60

agccgggcgg agggcccacg agggctcagc cttcccggtc agcggtggtg acggtatccc    120

agagtgccag agaaccgttg cttttccgag ttgctcttct tccaggctcc gttggtggtc    180

ggcatggccc gtggaaatca acgagaactt gcccgccaga aaaacatgaa gaaaacccag    240

gaaattagca agggaaagag gaaagaggat agcttgactg cctctcagag aaagcagagt    300

tctggaggcc agaaatctga gagcaagatg tcagctgggc cacacctccc tctgaaggct    360

ccaagggaga atccttgctt tcctcttcca gctgctggtg gctccaggta ttacttggct    420

tatggcagca taactcctat ctctgccttt gtctttgtgg tcttcttttc tgtcttcttc    480

ccttcttttt atgaggactt ttgctgttgg atttaggttc cattctaacc taggatgatc    540

tcatttggaa atccttaatt tcatctacaa aaactgtttt cccaaatagg tcacattcac    600

gcatatcaga tggacagatg tatcattttg gggtccacca ttcaacccac tacaaggagt    660

tttttaaaca aaaataggaa acttagatgt aacttagcac tttttttttt tttttttgag    720

atggagtctc actctgtcac cagactggag tgcagtggcg ccatctcagc tccatgcaac    780

ctctgcctcc tgggttcaag cagttctctt gcctcagcct cctgggtagc tgggattaca    840

ggcacgcgct gccacaccca ggtaatttat ttattttttt tttgagacag agtctcgcac    900

tgttgcccag gctggactgc agtggcgtga tctctgctca ctgcaacctc cgcctcccgg    960

gttcaagcga ttctccagcc tcagcttcct gagtagatgg gattacaggc gcctgccacc   1020

acgcccagct aatttttttg tattcttagt agagatgggg tttcaccatg ttggccaggc   1080

tggtctccat ctcctgacct cgtgattcac ccgcctcggc ctcccaaagt gctgggatta   1140

caggcgtgag tcacagcccc cggccataat ttagcacttt aaaaaataat agccatgttg   1200

ggccaggcgt ggtggctcat gcctgtaatc tgagcacttt gggagaccaa ggcgggtaga   1260

tcccttgtgc ccaggagttc aagaccagcc tgggcaacat ggcgaaaccc catttctact   1320

aaaaatacaa aaattagctg gggcgagggg ataggccgag ttccgggtgt aagggggcca   1380

ttagggagag cagagcgagg cagctgatct tccggattgg gggccttgcc cggaagctgg   1440

acctcacgga gatgaaacgg aagatgcacg aggatatgat ctccatacag aactttctca   1500

tctacgtggc cctgctgcga gtcactccat ttatcttaaa gaaattggac agcatatgaa   1560

gattggacat cacatgtgaa tgcatgatat gaagagcctg gttacagttt ctactgttct   1620

ctgcaagtaa ataggcccag aaaggtataa gagactcttt gaatggacat aaaaattctg   1680

cttgttaaga acaagttgag ctctggtaac tgatcttaat agctaaaata taaaaatatt   1740

tgggaagtct gaaatgaggt ctcctggccc tggtgtgccc ttaatgcctg tgacagttgg   1800

cctctgtgaa tattggtata attgtaaata atgtcaaact ccattttcta gcaagtatta   1860

ataattaagg gaagtatgtc tgaaatggca aaaaaaaaaa aaaaaaaaaa aa           1912


<210>  1014
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  1014

Met Ala Arg Gly Asn Gln Arg Glu Leu Ala Arg Gln Lys Asn Met Lys 
1               5                   10                  15      


Lys Thr Gln Glu Ile Ser Lys Gly Lys Arg Lys Glu Asp Ser Leu Thr 
            20                  25                  30          


Ala Ser Gln Arg Lys Gln Ser Ser Gly Gly Gln Lys Ser Glu Ser Lys 
        35                  40                  45              


Met Ser Ala Gly Pro His Leu Pro Leu Lys Ala Pro Arg Glu Asn Pro 
    50                  55                  60                  


Cys Phe Pro Leu Pro Ala Ala Gly Gly Ser Arg Tyr Tyr Leu Ala Tyr 
65                  70                  75                  80  


Gly Ser Ile Thr Pro Ile Ser Ala Phe Val Phe Val Val Phe Phe Ser 
                85                  90                  95      


Val Phe Phe Pro Ser Phe Tyr Glu Asp Phe Cys Cys Trp Ile 
            100                 105                 110 


<210>  1015
<211>  1621
<212>  DNA
<213>  Homosapiens

<400>  1015
ccacaaatgt gggagggcga taaccactcg tagaaagcgt gagaagttac tacaagcggt     60

cctcccggcc accgtactgt tccgctccca gaagccccgg gcggcggaag tcgtcactct    120

taagaaggga cggggcccca cgctgcgcac ccgcgggttt gctatggcga tgagcagcgg    180

cggcagtggt ggcggcgtcc cggagcagga ggattccgtg ctgttccggc gcggcacagg    240

ccagagcgat gattctgaca tttgggatga tacagcactg ataaaagcat atgataaagc    300

tgtggcttca tttaagcatg ctctaaagaa tggtgacatt tgtgaaactt cgggtaaacc    360

aaaaaccaca cctaaaagaa aacctgctaa gaagaataaa agccaaaaga agaatactgc    420

agcttcctta caacagtgga aagttgggga caaatgttct gccatttggt cagaagacgg    480

ttgcatttac ccagctacca ttgcttcaat tgattttaag agagaaacct gtgttgtggt    540

ttacactgga tatggaaata gagaggagca aaatctgtcc gatctacttt ccccaatctg    600

tgaagtagct aataatatag aacagaatgc tcaagagaat gaaaatgaaa gccaagtttc    660

aacagatgaa agtgagaact ccaggtctcc tggaaataaa tcagataaca tcaagcccaa    720

atctgctcca tggaactctt ttctccctcc accacccccc atgccagggc caagactggg    780

accaggaaag ccaggtctaa aattcaatgg cccaccaccg ccaccgccac caccaccacc    840

ccacttacta tcatgctggc tgcctccatt tccttctgga ccaccaataa ttcccccacc    900

acctcccata tgtccagatt ctcttgatga tgctgatgct ttgggaagta tgttaatttc    960

atggtacatg agtggctatc atactggcta ttatatgggt ttcagacaaa atcaaaaaga   1020

aggaaggtgc tcacattcct taaattaagg agaaatgctg gcatagagca gcactaaatg   1080

acaccactaa agaaacgatc agacagatct ggaatgtgaa gcgttataga agataactgg   1140

cctcatttct tcaaaatatc aagtgttggg aaagaaaaaa ggaagtggaa tgggtaactc   1200

ttcttgatta aaagttatgt aataaccaaa tgcaatgtga aatattttac tggactcttt   1260

tgaaaaacca tctgtaaaag actggggtgg gggtgggagg ccagcacggt ggtgaggcag   1320

ttgagaaaat ttgaatgtgg attagatttt gaatgatatt ggataattat tggtaatttt   1380

atggcctgtg agaagggtgt tgtagtttat aaaagactgt cttaatttgc atacttaagc   1440

atttaggaat gaagtgttag agtgtcttaa aatgtttcaa atggtttaac aaaatgtatg   1500

tgaggcgtat gtggcaaaat gttacagaat ctaactggtg gacatggctg ttcattgtac   1560

tgtttttttc tatcttctat atgtttaaaa gtatataata aaaatattta attttttttt   1620

a                                                                   1621


<210>  1016
<211>  294
<212>  PRT
<213>  Homosapiens

<400>  1016

Met Ala Met Ser Ser Gly Gly Ser Gly Gly Gly Val Pro Glu Gln Glu 
1               5                   10                  15      


Asp Ser Val Leu Phe Arg Arg Gly Thr Gly Gln Ser Asp Asp Ser Asp 
            20                  25                  30          


Ile Trp Asp Asp Thr Ala Leu Ile Lys Ala Tyr Asp Lys Ala Val Ala 
        35                  40                  45              


Ser Phe Lys His Ala Leu Lys Asn Gly Asp Ile Cys Glu Thr Ser Gly 
    50                  55                  60                  


Lys Pro Lys Thr Thr Pro Lys Arg Lys Pro Ala Lys Lys Asn Lys Ser 
65                  70                  75                  80  


Gln Lys Lys Asn Thr Ala Ala Ser Leu Gln Gln Trp Lys Val Gly Asp 
                85                  90                  95      


Lys Cys Ser Ala Ile Trp Ser Glu Asp Gly Cys Ile Tyr Pro Ala Thr 
            100                 105                 110         


Ile Ala Ser Ile Asp Phe Lys Arg Glu Thr Cys Val Val Val Tyr Thr 
        115                 120                 125             


Gly Tyr Gly Asn Arg Glu Glu Gln Asn Leu Ser Asp Leu Leu Ser Pro 
    130                 135                 140                 


Ile Cys Glu Val Ala Asn Asn Ile Glu Gln Asn Ala Gln Glu Asn Glu 
145                 150                 155                 160 


Asn Glu Ser Gln Val Ser Thr Asp Glu Ser Glu Asn Ser Arg Ser Pro 
                165                 170                 175     


Gly Asn Lys Ser Asp Asn Ile Lys Pro Lys Ser Ala Pro Trp Asn Ser 
            180                 185                 190         


Phe Leu Pro Pro Pro Pro Pro Met Pro Gly Pro Arg Leu Gly Pro Gly 
        195                 200                 205             


Lys Pro Gly Leu Lys Phe Asn Gly Pro Pro Pro Pro Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro His Leu Leu Ser Cys Trp Leu Pro Pro Phe Pro Ser Gly Pro 
225                 230                 235                 240 


Pro Ile Ile Pro Pro Pro Pro Pro Ile Cys Pro Asp Ser Leu Asp Asp 
                245                 250                 255     


Ala Asp Ala Leu Gly Ser Met Leu Ile Ser Trp Tyr Met Ser Gly Tyr 
            260                 265                 270         


His Thr Gly Tyr Tyr Met Gly Phe Arg Gln Asn Gln Lys Glu Gly Arg 
        275                 280                 285             


Cys Ser His Ser Leu Asn 
    290                 


<210>  1017
<211>  1525
<212>  DNA
<213>  Homosapiens

<400>  1017
ccacaaatgt gggagggcga taaccactcg tagaaagcgt gagaagttac tacaagcggt     60

cctcccggcc accgtactgt tccgctccca gaagccccgg gcggcggaag tcgtcactct    120

taagaaggga cggggcccca cgctgcgcac ccgcgggttt gctatggcga tgagcagcgg    180

cggcagtggt ggcggcgtcc cggagcagga ggattccgtg ctgttccggc gcggcacagg    240

ccagagcgat gattctgaca tttgggatga tacagcactg ataaaagcat atgataaagc    300

tgtggcttca tttaagcatg ctctaaagaa tggtgacatt tgtgaaactt cgggtaaacc    360

aaaaaccaca cctaaaagaa aacctgctaa gaagaataaa agccaaaaga agaatactgc    420

agcttcctta caacagtgga aagttgggga caaatgttct gccatttggt cagaagacgg    480

ttgcatttac ccagctacca ttgcttcaat tgattttaag agagaaacct gtgttgtggt    540

ttacactgga tatggaaata gagaggagca aaatctgtcc gatctacttt ccccaatctg    600

tgaagtagct aataatatag aacagaatgc tcaagagaat gaaaatgaaa gccaagtttc    660

aacagatgaa agtgagaact ccaggtctcc tggaaataaa tcagataaca tcaagcccaa    720

atctgctcca tggaactctt ttctccctcc accacccccc atgccagggc caagactggg    780

accaggaaag ataattcccc caccacctcc catatgtcca gattctcttg atgatgctga    840

tgctttggga agtatgttaa tttcatggta catgagtggc tatcatactg gctattatat    900

gggtttcaga caaaatcaaa aagaaggaag gtgctcacat tccttaaatt aaggagaaat    960

gctggcatag agcagcacta aatgacacca ctaaagaaac gatcagacag atctggaatg   1020

tgaagcgtta tagaagataa ctggcctcat ttcttcaaaa tatcaagtgt tgggaaagaa   1080

aaaaggaagt ggaatgggta actcttcttg attaaaagtt atgtaataac caaatgcaat   1140

gtgaaatatt ttactggact cttttgaaaa accatctgta aaagactggg gtgggggtgg   1200

gaggccagca cggtggtgag gcagttgaga aaatttgaat gtggattaga ttttgaatga   1260

tattggataa ttattggtaa ttttatggcc tgtgagaagg gtgttgtagt ttataaaaga   1320

ctgtcttaat ttgcatactt aagcatttag gaatgaagtg ttagagtgtc ttaaaatgtt   1380

tcaaatggtt taacaaaatg tatgtgaggc gtatgtggca aaatgttaca gaatctaact   1440

ggtggacatg gctgttcatt gtactgtttt tttctatctt ctatatgttt aaaagtatat   1500

aataaaaata tttaattttt tttta                                         1525


<210>  1018
<211>  262
<212>  PRT
<213>  Homosapiens

<400>  1018

Met Ala Met Ser Ser Gly Gly Ser Gly Gly Gly Val Pro Glu Gln Glu 
1               5                   10                  15      


Asp Ser Val Leu Phe Arg Arg Gly Thr Gly Gln Ser Asp Asp Ser Asp 
            20                  25                  30          


Ile Trp Asp Asp Thr Ala Leu Ile Lys Ala Tyr Asp Lys Ala Val Ala 
        35                  40                  45              


Ser Phe Lys His Ala Leu Lys Asn Gly Asp Ile Cys Glu Thr Ser Gly 
    50                  55                  60                  


Lys Pro Lys Thr Thr Pro Lys Arg Lys Pro Ala Lys Lys Asn Lys Ser 
65                  70                  75                  80  


Gln Lys Lys Asn Thr Ala Ala Ser Leu Gln Gln Trp Lys Val Gly Asp 
                85                  90                  95      


Lys Cys Ser Ala Ile Trp Ser Glu Asp Gly Cys Ile Tyr Pro Ala Thr 
            100                 105                 110         


Ile Ala Ser Ile Asp Phe Lys Arg Glu Thr Cys Val Val Val Tyr Thr 
        115                 120                 125             


Gly Tyr Gly Asn Arg Glu Glu Gln Asn Leu Ser Asp Leu Leu Ser Pro 
    130                 135                 140                 


Ile Cys Glu Val Ala Asn Asn Ile Glu Gln Asn Ala Gln Glu Asn Glu 
145                 150                 155                 160 


Asn Glu Ser Gln Val Ser Thr Asp Glu Ser Glu Asn Ser Arg Ser Pro 
                165                 170                 175     


Gly Asn Lys Ser Asp Asn Ile Lys Pro Lys Ser Ala Pro Trp Asn Ser 
            180                 185                 190         


Phe Leu Pro Pro Pro Pro Pro Met Pro Gly Pro Arg Leu Gly Pro Gly 
        195                 200                 205             


Lys Ile Ile Pro Pro Pro Pro Pro Ile Cys Pro Asp Ser Leu Asp Asp 
    210                 215                 220                 


Ala Asp Ala Leu Gly Ser Met Leu Ile Ser Trp Tyr Met Ser Gly Tyr 
225                 230                 235                 240 


His Thr Gly Tyr Tyr Met Gly Phe Arg Gln Asn Gln Lys Glu Gly Arg 
                245                 250                 255     


Cys Ser His Ser Leu Asn 
            260         


<210>  1019
<211>  1623
<212>  DNA
<213>  Homosapiens

<400>  1019
ccacaaatgt gggagggcga taaccactcg tagaaagcgt gagaagttac tacaagcggt     60

cctcccggcc accgtactgt tccgctccca gaagccccgg gcggcggaag tcgtcactct    120

taagaaggga cggggcccca cgctgcgcac ccgcgggttt gctatggcga tgagcagcgg    180

cggcagtggt ggcggcgtcc cggagcagga ggattccgtg ctgttccggc gcggcacagg    240

ccagagcgat gattctgaca tttgggatga tacagcactg ataaaagcat atgataaagc    300

tgtggcttca tttaagcatg ctctaaagaa tggtgacatt tgtgaaactt cgggtaaacc    360

aaaaaccaca cctaaaagaa aacctgctaa gaagaataaa agccaaaaga agaatactgc    420

agcttcctta caacagtgga aagttgggga caaatgttct gccatttggt cagaagacgg    480

ttgcatttac ccagctacca ttgcttcaat tgattttaag agagaaacct gtgttgtggt    540

ttacactgga tatggaaata gagaggagca aaatctgtcc gatctacttt ccccaatctg    600

tgaagtagct aataatatag aacagaatgc tcaagagaat gaaaatgaaa gccaagtttc    660

aacagatgaa agtgagaact ccaggtctcc tggaaataaa tcagataaca tcaagcccaa    720

atctgctcca tggaactctt ttctccctcc accacccccc atgccagggc caagactggg    780

accaggaaag ccaggtctaa aattcaatgg cccaccaccg ccaccgccac caccaccacc    840

ccacttacta tcatgctggc tgcctccatt tccttctgga ccaccaataa ttcccccacc    900

acctcccata tgtccagatt ctcttgatga tgctgatgct ttgggaagta tgttaatttc    960

atggtacatg agtggctatc atactggcta ttatatgggt tttagacaaa atcaaaaaga   1020

aggaaggtgc tcacattcct taaattaagg agaaatgctg gcatagagca gcactaaatg   1080

acaccactaa agaaacgatc agacagatct ggaatgtgaa gcgttataga agataactgg   1140

cctcatttct tcaaaatatc aagtgttggg aaagaaaaaa ggaagtggaa tgggtaactc   1200

ttcttgatta aaagttatgt aataaccaaa tgcaatgtga aatattttac tggactcttt   1260

tgaaaaacca tctgtaaaag actgaggtgg gggtgggagg ccagcacggt ggtgaggcag   1320

ttgagaaaat ttgaatgtgg attagatttt gaatgatatt ggataattat tggtaatttt   1380

atggcctgtg agaagggtgt tgtagtttat aaaagactgt cttaatttgc atacttaagc   1440

atttaggaat gaagtgttag agtgtcttaa aatgtttcaa atggtttaac aaaatgtatg   1500

tgaggcgtat gtggcaaaat gttacagaat ctaactggtg gacatggctg ttcattgtac   1560

tgtttttttc tatcttctat atgtttaaaa gtatataata aaaatattta attttttttt   1620

aaa                                                                 1623


<210>  1020
<211>  294
<212>  PRT
<213>  Homosapiens

<400>  1020

Met Ala Met Ser Ser Gly Gly Ser Gly Gly Gly Val Pro Glu Gln Glu 
1               5                   10                  15      


Asp Ser Val Leu Phe Arg Arg Gly Thr Gly Gln Ser Asp Asp Ser Asp 
            20                  25                  30          


Ile Trp Asp Asp Thr Ala Leu Ile Lys Ala Tyr Asp Lys Ala Val Ala 
        35                  40                  45              


Ser Phe Lys His Ala Leu Lys Asn Gly Asp Ile Cys Glu Thr Ser Gly 
    50                  55                  60                  


Lys Pro Lys Thr Thr Pro Lys Arg Lys Pro Ala Lys Lys Asn Lys Ser 
65                  70                  75                  80  


Gln Lys Lys Asn Thr Ala Ala Ser Leu Gln Gln Trp Lys Val Gly Asp 
                85                  90                  95      


Lys Cys Ser Ala Ile Trp Ser Glu Asp Gly Cys Ile Tyr Pro Ala Thr 
            100                 105                 110         


Ile Ala Ser Ile Asp Phe Lys Arg Glu Thr Cys Val Val Val Tyr Thr 
        115                 120                 125             


Gly Tyr Gly Asn Arg Glu Glu Gln Asn Leu Ser Asp Leu Leu Ser Pro 
    130                 135                 140                 


Ile Cys Glu Val Ala Asn Asn Ile Glu Gln Asn Ala Gln Glu Asn Glu 
145                 150                 155                 160 


Asn Glu Ser Gln Val Ser Thr Asp Glu Ser Glu Asn Ser Arg Ser Pro 
                165                 170                 175     


Gly Asn Lys Ser Asp Asn Ile Lys Pro Lys Ser Ala Pro Trp Asn Ser 
            180                 185                 190         


Phe Leu Pro Pro Pro Pro Pro Met Pro Gly Pro Arg Leu Gly Pro Gly 
        195                 200                 205             


Lys Pro Gly Leu Lys Phe Asn Gly Pro Pro Pro Pro Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro His Leu Leu Ser Cys Trp Leu Pro Pro Phe Pro Ser Gly Pro 
225                 230                 235                 240 


Pro Ile Ile Pro Pro Pro Pro Pro Ile Cys Pro Asp Ser Leu Asp Asp 
                245                 250                 255     


Ala Asp Ala Leu Gly Ser Met Leu Ile Ser Trp Tyr Met Ser Gly Tyr 
            260                 265                 270         


His Thr Gly Tyr Tyr Met Gly Phe Arg Gln Asn Gln Lys Glu Gly Arg 
        275                 280                 285             


Cys Ser His Ser Leu Asn 
    290                 


<210>  1021
<211>  1569
<212>  DNA
<213>  Homosapiens

<400>  1021
ccacaaatgt gggagggcga taaccactcg tagaaagcgt gagaagttac tacaagcggt     60

cctcccggcc accgtactgt tccgctccca gaagccccgg gcggcggaag tcgtcactct    120

taagaaggga cggggcccca cgctgcgcac ccgcgggttt gctatggcga tgagcagcgg    180

cggcagtggt ggcggcgtcc cggagcagga ggattccgtg ctgttccggc gcggcacagg    240

ccagagcgat gattctgaca tttgggatga tacagcactg ataaaagcat atgataaagc    300

tgtggcttca tttaagcatg ctctaaagaa tggtgacatt tgtgaaactt cgggtaaacc    360

aaaaaccaca cctaaaagaa aacctgctaa gaagaataaa agccaaaaga agaatactgc    420

agcttcctta caacagtgga aagttgggga caaatgttct gccatttggt cagaagacgg    480

ttgcatttac ccagctacca ttgcttcaat tgattttaag agagaaacct gtgttgtggt    540

ttacactgga tatggaaata gagaggagca aaatctgtcc gatctacttt ccccaatctg    600

tgaagtagct aataatatag aacagaatgc tcaagagaat gaaaatgaaa gccaagtttc    660

aacagatgaa agtgagaact ccaggtctcc tggaaataaa tcagataaca tcaagcccaa    720

atctgctcca tggaactctt ttctccctcc accacccccc atgccagggc caagactggg    780

accaggaaag ccaggtctaa aattcaatgg cccaccaccg ccaccgccac caccaccacc    840

ccacttacta tcatgctggc tgcctccatt tccttctgga ccaccaataa ttcccccacc    900

acctcccata tgtccagatt ctcttgatga tgctgatgct ttgggaagta tgttaatttc    960

atggtacatg agtggctatc atactggcta ttatatggaa atgctggcat agagcagcac   1020

taaatgacac cactaaagaa acgatcagac agatctggaa tgtgaagcgt tatagaagat   1080

aactggcctc atttcttcaa aatatcaagt gttgggaaag aaaaaaggaa gtggaatggg   1140

taactcttct tgattaaaag ttatgtaata accaaatgca atgtgaaata ttttactgga   1200

ctcttttgaa aaaccatctg taaaagactg aggtgggggt gggaggccag cacggtggtg   1260

aggcagttga gaaaatttga atgtggatta gattttgaat gatattggat aattattggt   1320

aattttatgg cctgtgagaa gggtgttgta gtttataaaa gactgtctta atttgcatac   1380

ttaagcattt aggaatgaag tgttagagtg tcttaaaatg tttcaaatgg tttaacaaaa   1440

tgtatgtgag gcgtatgtgg caaaatgtta cagaatctaa ctggtggaca tggctgttca   1500

ttgtactgtt tttttctatc ttctatatgt ttaaaagtat ataataaaaa tatttaattt   1560

ttttttaaa                                                           1569


<210>  1022
<211>  282
<212>  PRT
<213>  Homosapiens

<400>  1022

Met Ala Met Ser Ser Gly Gly Ser Gly Gly Gly Val Pro Glu Gln Glu 
1               5                   10                  15      


Asp Ser Val Leu Phe Arg Arg Gly Thr Gly Gln Ser Asp Asp Ser Asp 
            20                  25                  30          


Ile Trp Asp Asp Thr Ala Leu Ile Lys Ala Tyr Asp Lys Ala Val Ala 
        35                  40                  45              


Ser Phe Lys His Ala Leu Lys Asn Gly Asp Ile Cys Glu Thr Ser Gly 
    50                  55                  60                  


Lys Pro Lys Thr Thr Pro Lys Arg Lys Pro Ala Lys Lys Asn Lys Ser 
65                  70                  75                  80  


Gln Lys Lys Asn Thr Ala Ala Ser Leu Gln Gln Trp Lys Val Gly Asp 
                85                  90                  95      


Lys Cys Ser Ala Ile Trp Ser Glu Asp Gly Cys Ile Tyr Pro Ala Thr 
            100                 105                 110         


Ile Ala Ser Ile Asp Phe Lys Arg Glu Thr Cys Val Val Val Tyr Thr 
        115                 120                 125             


Gly Tyr Gly Asn Arg Glu Glu Gln Asn Leu Ser Asp Leu Leu Ser Pro 
    130                 135                 140                 


Ile Cys Glu Val Ala Asn Asn Ile Glu Gln Asn Ala Gln Glu Asn Glu 
145                 150                 155                 160 


Asn Glu Ser Gln Val Ser Thr Asp Glu Ser Glu Asn Ser Arg Ser Pro 
                165                 170                 175     


Gly Asn Lys Ser Asp Asn Ile Lys Pro Lys Ser Ala Pro Trp Asn Ser 
            180                 185                 190         


Phe Leu Pro Pro Pro Pro Pro Met Pro Gly Pro Arg Leu Gly Pro Gly 
        195                 200                 205             


Lys Pro Gly Leu Lys Phe Asn Gly Pro Pro Pro Pro Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro His Leu Leu Ser Cys Trp Leu Pro Pro Phe Pro Ser Gly Pro 
225                 230                 235                 240 


Pro Ile Ile Pro Pro Pro Pro Pro Ile Cys Pro Asp Ser Leu Asp Asp 
                245                 250                 255     


Ala Asp Ala Leu Gly Ser Met Leu Ile Ser Trp Tyr Met Ser Gly Tyr 
            260                 265                 270         


His Thr Gly Tyr Tyr Met Glu Met Leu Ala 
        275                 280         


<210>  1023
<211>  1527
<212>  DNA
<213>  Homosapiens

<400>  1023
ccacaaatgt gggagggcga taaccactcg tagaaagcgt gagaagttac tacaagcggt     60

cctcccggcc accgtactgt tccgctccca gaagccccgg gcggcggaag tcgtcactct    120

taagaaggga cggggcccca cgctgcgcac ccgcgggttt gctatggcga tgagcagcgg    180

cggcagtggt ggcggcgtcc cggagcagga ggattccgtg ctgttccggc gcggcacagg    240

ccagagcgat gattctgaca tttgggatga tacagcactg ataaaagcat atgataaagc    300

tgtggcttca tttaagcatg ctctaaagaa tggtgacatt tgtgaaactt cgggtaaacc    360

aaaaaccaca cctaaaagaa aacctgctaa gaagaataaa agccaaaaga agaatactgc    420

agcttcctta caacagtgga aagttgggga caaatgttct gccatttggt cagaagacgg    480

ttgcatttac ccagctacca ttgcttcaat tgattttaag agagaaacct gtgttgtggt    540

ttacactgga tatggaaata gagaggagca aaatctgtcc gatctacttt ccccaatctg    600

tgaagtagct aataatatag aacagaatgc tcaagagaat gaaaatgaaa gccaagtttc    660

aacagatgaa agtgagaact ccaggtctcc tggaaataaa tcagataaca tcaagcccaa    720

atctgctcca tggaactctt ttctccctcc accacccccc atgccagggc caagactggg    780

accaggaaag ataattcccc caccacctcc catatgtcca gattctcttg atgatgctga    840

tgctttggga agtatgttaa tttcatggta catgagtggc tatcatactg gctattatat    900

gggttttaga caaaatcaaa aagaaggaag gtgctcacat tccttaaatt aaggagaaat    960

gctggcatag agcagcacta aatgacacca ctaaagaaac gatcagacag atctggaatg   1020

tgaagcgtta tagaagataa ctggcctcat ttcttcaaaa tatcaagtgt tgggaaagaa   1080

aaaaggaagt ggaatgggta actcttcttg attaaaagtt atgtaataac caaatgcaat   1140

gtgaaatatt ttactggact cttttgaaaa accatctgta aaagactgag gtgggggtgg   1200

gaggccagca cggtggtgag gcagttgaga aaatttgaat gtggattaga ttttgaatga   1260

tattggataa ttattggtaa ttttatggcc tgtgagaagg gtgttgtagt ttataaaaga   1320

ctgtcttaat ttgcatactt aagcatttag gaatgaagtg ttagagtgtc ttaaaatgtt   1380

tcaaatggtt taacaaaatg tatgtgaggc gtatgtggca aaatgttaca gaatctaact   1440

ggtggacatg gctgttcatt gtactgtttt tttctatctt ctatatgttt aaaagtatat   1500

aataaaaata tttaattttt ttttaaa                                       1527


<210>  1024
<211>  262
<212>  PRT
<213>  Homosapiens

<400>  1024

Met Ala Met Ser Ser Gly Gly Ser Gly Gly Gly Val Pro Glu Gln Glu 
1               5                   10                  15      


Asp Ser Val Leu Phe Arg Arg Gly Thr Gly Gln Ser Asp Asp Ser Asp 
            20                  25                  30          


Ile Trp Asp Asp Thr Ala Leu Ile Lys Ala Tyr Asp Lys Ala Val Ala 
        35                  40                  45              


Ser Phe Lys His Ala Leu Lys Asn Gly Asp Ile Cys Glu Thr Ser Gly 
    50                  55                  60                  


Lys Pro Lys Thr Thr Pro Lys Arg Lys Pro Ala Lys Lys Asn Lys Ser 
65                  70                  75                  80  


Gln Lys Lys Asn Thr Ala Ala Ser Leu Gln Gln Trp Lys Val Gly Asp 
                85                  90                  95      


Lys Cys Ser Ala Ile Trp Ser Glu Asp Gly Cys Ile Tyr Pro Ala Thr 
            100                 105                 110         


Ile Ala Ser Ile Asp Phe Lys Arg Glu Thr Cys Val Val Val Tyr Thr 
        115                 120                 125             


Gly Tyr Gly Asn Arg Glu Glu Gln Asn Leu Ser Asp Leu Leu Ser Pro 
    130                 135                 140                 


Ile Cys Glu Val Ala Asn Asn Ile Glu Gln Asn Ala Gln Glu Asn Glu 
145                 150                 155                 160 


Asn Glu Ser Gln Val Ser Thr Asp Glu Ser Glu Asn Ser Arg Ser Pro 
                165                 170                 175     


Gly Asn Lys Ser Asp Asn Ile Lys Pro Lys Ser Ala Pro Trp Asn Ser 
            180                 185                 190         


Phe Leu Pro Pro Pro Pro Pro Met Pro Gly Pro Arg Leu Gly Pro Gly 
        195                 200                 205             


Lys Ile Ile Pro Pro Pro Pro Pro Ile Cys Pro Asp Ser Leu Asp Asp 
    210                 215                 220                 


Ala Asp Ala Leu Gly Ser Met Leu Ile Ser Trp Tyr Met Ser Gly Tyr 
225                 230                 235                 240 


His Thr Gly Tyr Tyr Met Gly Phe Arg Gln Asn Gln Lys Glu Gly Arg 
                245                 250                 255     


Cys Ser His Ser Leu Asn 
            260         


<210>  1025
<211>  1473
<212>  DNA
<213>  Homosapiens

<400>  1025
ccacaaatgt gggagggcga taaccactcg tagaaagcgt gagaagttac tacaagcggt     60

cctcccggcc accgtactgt tccgctccca gaagccccgg gcggcggaag tcgtcactct    120

taagaaggga cggggcccca cgctgcgcac ccgcgggttt gctatggcga tgagcagcgg    180

cggcagtggt ggcggcgtcc cggagcagga ggattccgtg ctgttccggc gcggcacagg    240

ccagagcgat gattctgaca tttgggatga tacagcactg ataaaagcat atgataaagc    300

tgtggcttca tttaagcatg ctctaaagaa tggtgacatt tgtgaaactt cgggtaaacc    360

aaaaaccaca cctaaaagaa aacctgctaa gaagaataaa agccaaaaga agaatactgc    420

agcttcctta caacagtgga aagttgggga caaatgttct gccatttggt cagaagacgg    480

ttgcatttac ccagctacca ttgcttcaat tgattttaag agagaaacct gtgttgtggt    540

ttacactgga tatggaaata gagaggagca aaatctgtcc gatctacttt ccccaatctg    600

tgaagtagct aataatatag aacagaatgc tcaagagaat gaaaatgaaa gccaagtttc    660

aacagatgaa agtgagaact ccaggtctcc tggaaataaa tcagataaca tcaagcccaa    720

atctgctcca tggaactctt ttctccctcc accacccccc atgccagggc caagactggg    780

accaggaaag ataattcccc caccacctcc catatgtcca gattctcttg atgatgctga    840

tgctttggga agtatgttaa tttcatggta catgagtggc tatcatactg gctattatat    900

ggaaatgctg gcatagagca gcactaaatg acaccactaa agaaacgatc agacagatct    960

ggaatgtgaa gcgttataga agataactgg cctcatttct tcaaaatatc aagtgttggg   1020

aaagaaaaaa ggaagtggaa tgggtaactc ttcttgatta aaagttatgt aataaccaaa   1080

tgcaatgtga aatattttac tggactcttt tgaaaaacca tctgtaaaag actgaggtgg   1140

gggtgggagg ccagcacggt ggtgaggcag ttgagaaaat ttgaatgtgg attagatttt   1200

gaatgatatt ggataattat tggtaatttt atggcctgtg agaagggtgt tgtagtttat   1260

aaaagactgt cttaatttgc atacttaagc atttaggaat gaagtgttag agtgtcttaa   1320

aatgtttcaa atggtttaac aaaatgtatg tgaggcgtat gtggcaaaat gttacagaat   1380

ctaactggtg gacatggctg ttcattgtac tgtttttttc tatcttctat atgtttaaaa   1440

gtatataata aaaatattta attttttttt aaa                                1473


<210>  1026
<211>  250
<212>  PRT
<213>  Homosapiens

<400>  1026

Met Ala Met Ser Ser Gly Gly Ser Gly Gly Gly Val Pro Glu Gln Glu 
1               5                   10                  15      


Asp Ser Val Leu Phe Arg Arg Gly Thr Gly Gln Ser Asp Asp Ser Asp 
            20                  25                  30          


Ile Trp Asp Asp Thr Ala Leu Ile Lys Ala Tyr Asp Lys Ala Val Ala 
        35                  40                  45              


Ser Phe Lys His Ala Leu Lys Asn Gly Asp Ile Cys Glu Thr Ser Gly 
    50                  55                  60                  


Lys Pro Lys Thr Thr Pro Lys Arg Lys Pro Ala Lys Lys Asn Lys Ser 
65                  70                  75                  80  


Gln Lys Lys Asn Thr Ala Ala Ser Leu Gln Gln Trp Lys Val Gly Asp 
                85                  90                  95      


Lys Cys Ser Ala Ile Trp Ser Glu Asp Gly Cys Ile Tyr Pro Ala Thr 
            100                 105                 110         


Ile Ala Ser Ile Asp Phe Lys Arg Glu Thr Cys Val Val Val Tyr Thr 
        115                 120                 125             


Gly Tyr Gly Asn Arg Glu Glu Gln Asn Leu Ser Asp Leu Leu Ser Pro 
    130                 135                 140                 


Ile Cys Glu Val Ala Asn Asn Ile Glu Gln Asn Ala Gln Glu Asn Glu 
145                 150                 155                 160 


Asn Glu Ser Gln Val Ser Thr Asp Glu Ser Glu Asn Ser Arg Ser Pro 
                165                 170                 175     


Gly Asn Lys Ser Asp Asn Ile Lys Pro Lys Ser Ala Pro Trp Asn Ser 
            180                 185                 190         


Phe Leu Pro Pro Pro Pro Pro Met Pro Gly Pro Arg Leu Gly Pro Gly 
        195                 200                 205             


Lys Ile Ile Pro Pro Pro Pro Pro Ile Cys Pro Asp Ser Leu Asp Asp 
    210                 215                 220                 


Ala Asp Ala Leu Gly Ser Met Leu Ile Ser Trp Tyr Met Ser Gly Tyr 
225                 230                 235                 240 


His Thr Gly Tyr Tyr Met Glu Met Leu Ala 
                245                 250 


<210>  1027
<211>  6757
<212>  DNA
<213>  Homosapiens

<400>  1027
ttatatggtt tggctctgtc cgcacccaaa tctcatcttg aattgtaaca attcccatgt     60

gtcaagggtg gggccaggtg gagataactg aatcatggag gcagtttccc ccatgctgtt    120

ctcatggtag tgaataagtc tcatgaggtc tgatggtttt ataaatggat gttcccctgc    180

acatgctctc tcctgcccac catgtctgac taaattttgt atttttacta gagacgggct    240

ttcactatgt tggccaggct ggcctccaac tcctgatctc gtgatccgtc caccccgacc    300

tcccaaagtg ctaggatcat aggcataagc caccacaccc ggcctctttt ttttcttttt    360

ctttttttta tctggagact gagttttgca ctcgttgccc aggctggagt gcaatggtgc    420

gatctcagct cactgcagtc tccacctcag caggagagca ggaatcttca gtgatccacg    480

ggcaaatatg cagccattgt gggcacctgt tcctcccgcg acctttgtgc ccacgtctct    540

ccctccagta cctactgcac gaccccccac gtccgcctcc tgccattgcc agcaggtgcc    600

ttgcgcgggt acctggctgt gcttattcat ccattatggt cgctctgtca ctggtgccat    660

tatgtgctca catgcccact ccctcaggtt tagaagtcgc gttgcccggc aacagaacaa    720

tctgctggct tagcctttgg ccaagttggc agctggacga ggacgctcag agcccagctc    780

ttgagagttc aagtatccga cagttcccca ctgctcccag gagcggttac ccgggcactc    840

tgtgcccctc attcctgttt gggccaaggc cgaggacctg cgagtagggc tcagttgcct    900

ggagcccctt cagcccatcc cccagttcac tttgcttgtg ggatctcccc gttgctcctg    960

cccctggact gagtggcagg ccatcctaca aacacccgga cactcgacat cactggtgtc   1020

aagacaactc taagaaggtt ttccgtgatc ctgcaagacc tgtgttccat cctggtgatt   1080

ccgtcttcaa tttcactgca caggtaccac agtaagccag tgctgtgtgc tccgagttcc   1140

agggcatccc ccagcccagc cactacactg agcacaagga ctctgtgggg cccaggagca   1200

ggtagtcacc cctttggggt ccacaacacc cggctgtccc cagacttgtg tccagggaag   1260

atagtgttga gggccctcaa ggagagcggg gcagggatgc ctgagcagga caaggacccc   1320

agagtccaag aaaatcctga tgatcagaga acggtccccg aggtcaccgg ggatgcacgg   1380

tctgcatttt ggcccctgcg ggacaatgga ggcccctctc cctttgtgcc caggcccggg   1440

cctctgcaga cagacctcca cgcccagagc tcagaaatca gatataacca cacatcccag   1500

acatcctgga cgagctcgag caccaaacga aatgccatct ccagctccta cagctccacg   1560

ggaggcttgc cggggctaaa gcagaggagg gggccagcct catcccgctg ccagctgacc   1620

ctcagttact caaagacagt gagtgaggac aggcctcagg ctgtctcttc gggtcacaca   1680

cggtgtgaaa agggggcaga tacagcacca gggcagacaa tcgccccaac gggtggctcc   1740

cccacatccc aggactctag gccccgtaga cgcaagattc ccctgctgcc acgcaggcga   1800

ggggagcctt tgatgctgcc acatcgctta gagctggggt accgggtcac ggctgaagac   1860

ctgcacctgg aaaaagagaa ggcattccag cgcatcaaca gtgcactgca cgttgaggac   1920

aaggccatct cggactgcag accctcacgg ccttcccaca ctttgtcctc acttgcaaca   1980

ggggcttcgg gtgggcctcc cgtttctaaa gcacccacta tggatgcaca gcaggacaga   2040

cccaagtccc aagactgcct gggcctagtg gcccccctag catctgcagc agaggtcccc   2100

gctacagctc ccgtgtctgg gaaaaagcac agaccaccag gacccctgtt ctccaactca   2160

gatccccttc cggccaactc ttcccactcc cgggactcag cccaggtcac ctcgatgatt   2220

cctgtcccct tgacagctgc aagcagggat gccggcatga gaagaacaag gtcggctcct   2280

gcagctgccg cagcagcccc tcccccctcc acattgaacc ccacgtcggg gtcactactc   2340

aatgcagtgg atggaggccc ctcacatttc ttggcctcag ccacagctgc agcacgtgtc   2400

cagaggtcag aagtgagata taaccagaga tcccagacct cccggaccag atcgtgcctc   2460

aaacgaaatg ccagctccag ctcccacagc tctacggaag gcctcccgca actaaagcgg   2520

aggagggggc cagcctcatc ccactgccag ctggcccaca gttcctcaaa cacagtgagt   2580

gaggatggac ctcaggctgt ctcttcgggt caccgctgtg aaaacaaggc aggtacagca   2640

ccagggcaga cacttgcccc caggggtggc tcccccagat cccaggcctc taggccccac   2700

atcaacactg cactgcacgt tgaggacaag gccatctcgg actgcagacc ctcacgacct   2760

tcccacactt tgtcctcatt tgcaacaggg gcttcgggtg ggcctcccgt ttctaaagca   2820

cccactatgg acgcacagca ggacagaccc aagtcccaag actgcctggg cctagtggcc   2880

cccctagcat ctgctgcaga ggtcccctct acagctcccg tgtctgggaa gaagcacaga   2940

ccaccaggac ccctgttctc ctcctcagat ccccttcctg ccacctcttc ccactcccgg   3000

gactcagccc aggtcacctc gctgattcct gccaccttca cagctgcaag cagggatgcc   3060

ggcatgagaa gaacaaggtc ggctcctgca gctgccgcag cagcccctcc cccctccaca   3120

ttgaacccca cgtcggggtc actactcaat gcagtggatg gaggcccctc acatttcttg   3180

gcctcagcca cagctgcagc acgtgcccag aggtcagaag tgagatataa ccagagatcc   3240

cagacctccc ggaccagatc ctgcctcaaa cgaaatgcca gctccagctc cagctccagc   3300

tcccacagct ctacggaagg cctccaggaa ctaaagcgga ggagggggcc agcctcatcc   3360

cactgccagc tggcccacag ttccccaaac acagtgagtg aggacggacc tcaggctgtc   3420

tcttcgggtc accgctgtga aaacaaggca ggtacagcac cagggcagac actcgccccc   3480

aggggtggct cccccagatc ccaggcctct aggccccgca tcaacactgc actgcacgtt   3540

gaggacaagg ccatctcgga ctgcagaccc tcacggcctt cccacacttt gtcctcactt   3600

gcaacagggg cttcgggtgg gcctcccgtt tctaaagcac ccactatgga tgcacagcag   3660

cacagaccca agtcccaaga ctgcctgggc ctactggccc ccctagcatc tgctgcagag   3720

gtcccctcta cagctcccgt gtctgggaag aagcacagac caccaggacc cctgttctcc   3780

tcctcagatc cccttcctgc cacctcttac cactcacggg actcagccca ggtcacctcg   3840

ctgattcccg cgcccttcac agctgcaagc agcgatgccg gcatgagaag aacaaggcct   3900

ggcacctcgg ctcctgcagc tgcagcagca gcccctcccc cctccacatt gaaccccacg   3960

tcggggtcac tactcaatgc agtggatgga agcccctcac atttcttggc ctcagccaca   4020

gctgcagcac gtgtccagag gtcagaagtg agatataacc agagatccca gacctcccgg   4080

accagatcct gcctccaagg aaatgccagc tccagctccc acagctctac ggaaggcctc   4140

ccgcaactaa agcggaggag ggggccagcc tcatcccact gccagctggc ccacagttcc   4200

tcaaacacag tgagtgagga cggacctcag gctgtctctt cgggtcacac ccgctgtgag   4260

aagaaggcag gtacagcacc agggcagaca cttgccccca ggggtggctc ccccagatcc   4320

caggcctcta ggccccgcat caacactgca ctgcacgttg aggacaaggc catctcggac   4380

tgcagaccct cacggccttc ccacactttg tcctcacttg caacaggggc ttcgggtggg   4440

cctcccgttt ctaaagcacc cactatggat gcacagcagg acagacccaa gtcccaagac   4500

tgcctgggcc tactggcccc cctagcatct gctgcagagg tctcctctac agctcccatg   4560

tctgggaaga agcacagacc accaggaccc ctgttctcct cctcagatcc ccttcctgcc   4620

acctcttccc actccgggga ctcagcccag gacacctcgc tgattcctgc ccccttcaca   4680

cctgcaagca gggatgccgg catcagaaga atgtttcgtg ttcgaaattg tttgaggggt   4740

ttgggtttat ttttgttggt tttttctttt ttttttttgc ttacgtgggc atccttcagc   4800

ttttaataat ctgaaaaatt ctatttaccc attgtcaatg tgtataaatt aatctcagtc   4860

aattttatac aataaaaggt gaacttttat ccatcaaaca ataatttaac aaaaaatgta   4920

ccggaagaag aatgttcatt acaaatatag gaaacataaa tattaccaaa tattggcaag   4980

cactaaaatg ttcagaaata taagtctatt acagttatag ctctctcaag caaaaaaaca   5040

gcagagaaaa acttagtttt cctgaggggc tatttattta cttagggatt tgttaaaagg   5100

tcaaatgggg tcacacagaa tactaagaag agctgttcac ccaggcctca ctaagaactc   5160

ttcttcatgc agtagctata tagtaatatg acaactgctc ctacgaccca aagaggaact   5220

acagcaacta ctctttagca tctgttgctc ccaactctgc tttgcaatta tatgactcaa   5280

gcattctggc tccgttaact attactgctg ttactcccaa gtaaattccc tctaaaaaat   5340

aaaaattttt aaagctgtaa tttaagctct ctgctgcctc atgacttcaa ttccatcaga   5400

gttacgcatt gtttcctctg tacatctttg ctctgcttcc attgctaatt ccctagtaaa   5460

gtgttgtata ttcaaagttc caaagaaaca gaatatccaa gacatcacca atcatccaaa   5520

acacagtgta ggaggccaca gttaagagaa gcaacaccat tagctctttt tataggctcg   5580

agaacaacag gatgctttgg tcctgtatca gcaggatgct ttttgggtag atcctactgc   5640

caccctacta tcgggtagat cctactgtca ccctagctat gggcacatgt cagagtccca   5700

tgtaataaag gagacaaaag gaaaccacca cgagtataaa ctaagaaaag tactccaagg   5760

tttctaagaa tggagctgta taactcactt tgccccgttt gttacttctc cacggtactt   5820

accaccacct attacatata ttttgtttat agtcagtctt cccccattag aatgaaagtt   5880

ccgtgaggat aggactatac agtcagccct cagtatccat gggggactgg tttcaggatc   5940

tcctgagggt aacaaaggat actcaagtcc ctgatataaa atgacatagt atttgcacat   6000

cacctttgca catcctccca tatacttcat atcaactcta gatcactcat aatatccgat   6060

gtaaatgtca tgcaaatagt tattgtacta tattgtgtaa ggaataagga caagaaaaaa   6120

gtctgtacat gttcagtaca gacgcaattt ttttttccaa tatttccaat ccttggttgc   6180

cttaacggat gtagaaccca ggaataagtt ctggtgtcct attgcatagt aggatgagta   6240

tagttaacaa taacatatta tatatttgaa aatagccaga agagtagatt ttgaattttc   6300

tccctacaga aaaatcatta tgcaaattac cctgatttga tcattacaca ttgagtacat   6360

gtattaaaac atcacattct accccatata tatgtacagt tattatgtgt ccataaaaat   6420

ttaatgtcaa tgtgtgaaat aaaatgaaaa aataaaaatt tttaaagctg taattatctc   6480

catctggtag gaatatatac aatctgaaat aaaaaatata tttgtaattg ttaggacaaa   6540

atagattata cattaagtct gcaaattata aattataaaa ttctcacaga acctgaaaaa   6600

ttattgatac tgttaaatat ttaaaaagct gtccttggag agaaagaaac ctatcagatt   6660

tacatcaaca agtgtaatat gtcagcctat taccatctgc tacagactgc atgtttgtgt   6720

tccctcaaaa ttcatatgat aggcccggcg cggtggc                            6757


<210>  1028
<211>  1169
<212>  PRT
<213>  Homosapiens

<400>  1028

Met Pro Glu Gln Asp Lys Asp Pro Arg Val Gln Glu Asn Pro Asp Asp 
1               5                   10                  15      


Gln Arg Thr Val Pro Glu Val Thr Gly Asp Ala Arg Ser Ala Phe Trp 
            20                  25                  30          


Pro Leu Arg Asp Asn Gly Gly Pro Ser Pro Phe Val Pro Arg Pro Gly 
        35                  40                  45              


Pro Leu Gln Thr Asp Leu His Ala Gln Ser Ser Glu Ile Arg Tyr Asn 
    50                  55                  60                  


His Thr Ser Gln Thr Ser Trp Thr Ser Ser Ser Thr Lys Arg Asn Ala 
65                  70                  75                  80  


Ile Ser Ser Ser Tyr Ser Ser Thr Gly Gly Leu Pro Gly Leu Lys Gln 
                85                  90                  95      


Arg Arg Gly Pro Ala Ser Ser Arg Cys Gln Leu Thr Leu Ser Tyr Ser 
            100                 105                 110         


Lys Thr Val Ser Glu Asp Arg Pro Gln Ala Val Ser Ser Gly His Thr 
        115                 120                 125             


Arg Cys Glu Lys Gly Ala Asp Thr Ala Pro Gly Gln Thr Ile Ala Pro 
    130                 135                 140                 


Thr Gly Gly Ser Pro Thr Ser Gln Asp Ser Arg Pro Arg Arg Arg Lys 
145                 150                 155                 160 


Ile Pro Leu Leu Pro Arg Arg Arg Gly Glu Pro Leu Met Leu Pro His 
                165                 170                 175     


Arg Leu Glu Leu Gly Tyr Arg Val Thr Ala Glu Asp Leu His Leu Glu 
            180                 185                 190         


Lys Glu Lys Ala Phe Gln Arg Ile Asn Ser Ala Leu His Val Glu Asp 
        195                 200                 205             


Lys Ala Ile Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser 
    210                 215                 220                 


Ser Leu Ala Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro 
225                 230                 235                 240 


Thr Met Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly 
                245                 250                 255     


Leu Val Ala Pro Leu Ala Ser Ala Ala Glu Val Pro Ala Thr Ala Pro 
            260                 265                 270         


Val Ser Gly Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Asn Ser 
        275                 280                 285             


Asp Pro Leu Pro Ala Asn Ser Ser His Ser Arg Asp Ser Ala Gln Val 
    290                 295                 300                 


Thr Ser Met Ile Pro Val Pro Leu Thr Ala Ala Ser Arg Asp Ala Gly 
305                 310                 315                 320 


Met Arg Arg Thr Arg Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro 
                325                 330                 335     


Pro Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp 
            340                 345                 350         


Gly Gly Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Val 
        355                 360                 365             


Gln Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr 
    370                 375                 380                 


Arg Ser Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr 
385                 390                 395                 400 


Glu Gly Leu Pro Gln Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser His 
                405                 410                 415     


Cys Gln Leu Ala His Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro 
            420                 425                 430         


Gln Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala 
        435                 440                 445             


Pro Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala 
    450                 455                 460                 


Ser Arg Pro His Ile Asn Thr Ala Leu His Val Glu Asp Lys Ala Ile 
465                 470                 475                 480 


Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Phe Ala 
                485                 490                 495     


Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp 
            500                 505                 510         


Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly Leu Val Ala 
        515                 520                 525             


Pro Leu Ala Ser Ala Ala Glu Val Pro Ser Thr Ala Pro Val Ser Gly 
    530                 535                 540                 


Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu 
545                 550                 555                 560 


Pro Ala Thr Ser Ser His Ser Arg Asp Ser Ala Gln Val Thr Ser Leu 
                565                 570                 575     


Ile Pro Ala Thr Phe Thr Ala Ala Ser Arg Asp Ala Gly Met Arg Arg 
            580                 585                 590         


Thr Arg Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro Pro Ser Thr 
        595                 600                 605             


Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Gly Gly Pro 
    610                 615                 620                 


Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala Gln Arg Ser 
625                 630                 635                 640 


Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg Ser Cys 
                645                 650                 655     


Leu Lys Arg Asn Ala Ser Ser Ser Ser Ser Ser Ser Ser His Ser Ser 
            660                 665                 670         


Thr Glu Gly Leu Gln Glu Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser 
        675                 680                 685             


His Cys Gln Leu Ala His Ser Ser Pro Asn Thr Val Ser Glu Asp Gly 
    690                 695                 700                 


Pro Gln Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr 
705                 710                 715                 720 


Ala Pro Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln 
                725                 730                 735     


Ala Ser Arg Pro Arg Ile Asn Thr Ala Leu His Val Glu Asp Lys Ala 
            740                 745                 750         


Ile Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu 
        755                 760                 765             


Ala Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met 
    770                 775                 780                 


Asp Ala Gln Gln His Arg Pro Lys Ser Gln Asp Cys Leu Gly Leu Leu 
785                 790                 795                 800 


Ala Pro Leu Ala Ser Ala Ala Glu Val Pro Ser Thr Ala Pro Val Ser 
                805                 810                 815     


Gly Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro 
            820                 825                 830         


Leu Pro Ala Thr Ser Tyr His Ser Arg Asp Ser Ala Gln Val Thr Ser 
        835                 840                 845             


Leu Ile Pro Ala Pro Phe Thr Ala Ala Ser Ser Asp Ala Gly Met Arg 
    850                 855                 860                 


Arg Thr Arg Pro Gly Thr Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro 
865                 870                 875                 880 


Pro Pro Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val 
                885                 890                 895     


Asp Gly Ser Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg 
            900                 905                 910         


Val Gln Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg 
        915                 920                 925             


Thr Arg Ser Cys Leu Gln Gly Asn Ala Ser Ser Ser Ser His Ser Ser 
    930                 935                 940                 


Thr Glu Gly Leu Pro Gln Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser 
945                 950                 955                 960 


His Cys Gln Leu Ala His Ser Ser Ser Asn Thr Val Ser Glu Asp Gly 
                965                 970                 975     


Pro Gln Ala Val Ser Ser Gly His Thr Arg Cys Glu Lys Lys Ala Gly 
            980                 985                 990         


Thr Ala Pro Gly Gln Thr Leu Ala  Pro Arg Gly Gly Ser  Pro Arg Ser 
        995                 1000                 1005             


Gln Ala  Ser Arg Pro Arg Ile  Asn Thr Ala Leu His  Val Glu Asp 
    1010                 1015                 1020             


Lys Ala  Ile Ser Asp Cys Arg  Pro Ser Arg Pro Ser  His Thr Leu 
    1025                 1030                 1035             


Ser Ser  Leu Ala Thr Gly Ala  Ser Gly Gly Pro Pro  Val Ser Lys 
    1040                 1045                 1050             


Ala Pro  Thr Met Asp Ala Gln  Gln Asp Arg Pro Lys  Ser Gln Asp 
    1055                 1060                 1065             


Cys Leu  Gly Leu Leu Ala Pro  Leu Ala Ser Ala Ala  Glu Val Ser 
    1070                 1075                 1080             


Ser Thr  Ala Pro Met Ser Gly  Lys Lys His Arg Pro  Pro Gly Pro 
    1085                 1090                 1095             


Leu Phe  Ser Ser Ser Asp Pro  Leu Pro Ala Thr Ser  Ser His Ser 
    1100                 1105                 1110             


Gly Asp  Ser Ala Gln Asp Thr  Ser Leu Ile Pro Ala  Pro Phe Thr 
    1115                 1120                 1125             


Pro Ala  Ser Arg Asp Ala Gly  Ile Arg Arg Met Phe  Arg Val Arg 
    1130                 1135                 1140             


Asn Cys  Leu Arg Gly Leu Gly  Leu Phe Leu Leu Val  Phe Ser Phe 
    1145                 1150                 1155             


Phe Phe  Leu Leu Thr Trp Ala  Ser Phe Ser Phe 
    1160                 1165                 


<210>  1029
<211>  7564
<212>  DNA
<213>  Homosapiens

<400>  1029
ttatatggtt tggctctgtc cgcacccaaa tctcatcttg aattgtaaca attcccatgt     60

gtcaagggtg gggccaggtg gagataactg aatcatggag gcagtttccc ccatgctgtt    120

ctcatggtag tgaataagtc tcatgaggtc tgatggtttt ataaatggat gttcccctgc    180

acatgctctc tcctgcccac catgtctgac taaattttgt atttttacta gagacgggct    240

ttcactatgt tggccaggct ggcctccaac tcctgatctc gtgatccgtc caccccgacc    300

tcccaaagtg ctaggatcat aggcataagc caccacaccc ggcctctttt ttttcttttt    360

ctttttttta tctggagact gagttttgca ctcgttgccc aggctggagt gcaatggtgc    420

gatctcagct cactgcagtc tccacctcag caggagagca ggaatcttca gtgatccacg    480

ggcaaatatg cagccattgt gggcacctgt tcctcccgcg acctttgtgc ccacgtctct    540

ccctccagta cctactgcac gaccccccac gtccgcctcc tgccattgcc agcaggtgcc    600

ttgcgcgggt acctggctgt gcttattcat ccattatggt cgctctgtca ctggtgccat    660

tatgtgctca catgcccact ccctcaggtt tagaagtcgc gttgcccggc aacagaacaa    720

tctgctggct tagcctttgg ccaagttggc agctggacga ggacgctcag agcccagctc    780

ttgagagttc aagtatccga cagttcccca ctgctcccag gagcggttac ccgggcactc    840

tgtgcccctc attcctgttt gggccaaggc cgaggacctg cgagtagggc tcagttgcct    900

ggagcccctt cagcccatcc cccagttcac tttgcttgtg ggatctcccc gttgctcctg    960

cccctggact gagtggcagg ccatcctaca aacacccgca cactcgacat cagtggtgtc   1020

aagacaactc taagaaggtt ttccgtgatc ctgcaagacc tgtgttccat cctggtgatt   1080

ctgtcttcaa tttcactgca caggtaccac agtaagccag tgctgtgtgc tccgagttcc   1140

agggcatccc ccagctcagc cactacactg agcacaagga ctctgtgggg cccaggagca   1200

ggtagtcacc cctttggggt ccacaacacc cggctgtccc cagacttgtg tccagggaag   1260

atagtgttga gggccctcaa ggagagcggg gcagggatgc ctgagcagga caaggacccc   1320

agagtccaag aaaatcctga tgatcagaga acggtccccg aggtcaccgg ggatgcacgg   1380

tctgcatttt ggcccctgcg ggacaatgga ggcccctctc cctttgtgcc caggcccggg   1440

cctctgcaga cagacctcca cgcccagagc tcagaaatca gatataacca cacatcccag   1500

acatcctgga cgagctcgag caccaaacga aatgccatct ccagctccta cagctccacg   1560

ggaggcttgc cggggctaaa gcagaggagg gggccagcct catcccgctg ccagctgacc   1620

ctcagttact caaagacagt gagtgaggac aggcctcagg ctgtctcttc gggtcacaca   1680

cggtgtgaaa agggggcaga tacagcacca gggcagacaa tcgccccaac gggtggctcc   1740

cccagatccc aggactctag gccccgtaga cgcaagattc ccctgctgcc acgcaggcga   1800

ggggagcctt tgatgctgcc acctccctta gagctggggt accgggtcac ggctgaagac   1860

ctgcacctgg aaaaagagac ggcattccag cgcatcaaca gtgcactgca cgttgaggac   1920

aaggccatcc cggactgcag accctcacgg ccttcccaca ctttgtcctc acttgcaaca   1980

ggggcttcgg gtgggcctcc cgtttctaaa gcacccacta tggatgcaca gcaggacaga   2040

cccaagtccc aagactgcct gggcctagtg gcccccctag catctgctgc agaggtcccc   2100

gctacagctc ccgtgtctgg gaagaagcac agaccaccag gacccctgtt ctcctcctca   2160

gatccccttc ctgccaactc ttcccactcc cgggactcag cccaggtcac ctcgatgatt   2220

cctgccccct tcacagctgc aagcagggat gccggcatga gaagaacaag gtcggctcct   2280

gcagctgccg cagcagcccc tcccccctcc acattgaacc ccacgtcggg gtcactactc   2340

aatgcagtgg atggaggccc ctcacatttc ttggcctcag ccacagctgc agcacgtgcc   2400

cagaggtcag aagtgagata taaccagaga tcccagacct cccggaccag atcctgcctc   2460

aaacgaaatg ccagctccag ctcccacagc tctacggaag gcctccagga agtaaagcgg   2520

aggagggggc cagcctcatc ccactgccag ctggccctca gttcctcaaa cacagtgagt   2580

gaggacggac ctcaggctgt ctcttcgggt caccactgtg aaaacaaggc aggtacagca   2640

ccagggcaga cacttgcccc caggggtggc tcccccagat cccaggcctc taggccccac   2700

atcaacactg cactgcacgt tgaggacaag gccatctcgg actgcagacc ctcacggcct   2760

tcccacactt tgtcctcact tgcaacaggg gcttcgggtg ggcctcccgt ttctaaagca   2820

cccactatgg atgcacagca ggacagaccc aagtcccaag actccctggg cctactggcc   2880

cccctagcat ctgctgcaga ggtcccctct acagctcccg tgtctgggaa gaagcacaga   2940

ccaccaggac ccctgttctc ctcctcagat ccccttcctg ccacctctta ccactcccgg   3000

gacacagcac aggtcacctc gctgattcct gccaccttca cagctgcaag cagggatgcc   3060

ggcatgagaa gaacaaggtc ggctcctgca gctgccacag cagcccctcc cccctccaca   3120

ttgaacaaca cgtcggggtc actactcaat gcagtggatg gaggcccctc acatttcttg   3180

gcctcagcca cagctgcagc acgtgcccag aggtcagaag tgagatataa ccagagatcc   3240

cagacctccc ggaccagatc ctgcctcaaa cgaaatgcca gctccagctc cagctcccac   3300

agctctacgg aaggcctcca ggaactaaag cggaggaggg ggccagcctc atcccactgc   3360

cagctggccc acagttcctc aaacacagtg agtgaggacg gacctcaggc tgtctcttcg   3420

ggtcaccgct gtgaaaacaa ggcaggtaca gcaccagggc agacactcgc ccccagggga   3480

ggctccccca gatcccaggc ctctaggccc cacatcaaca gtgcactgta cgttgaggac   3540

aaggccatct cggactgcag accctcacgg ccttcccaca ctttgtcctc acttgcaaca   3600

ggggcttcgg gtgggcctcc cgtttctaaa gcacccacta tggacgcaca gcaggacaga   3660

cccaagtccc aagactgcct gggcctagtg gcccccctag catctgctgc agaggtcccc   3720

tctacagctc ccgtgtctgg gaagaagcac agaccaccag gacccctgtt ctcctcctca   3780

gatccccttc ctgccacctc ttcccactcc cgggactcag cccaggtcac ctcgctgatt   3840

cctgccacct tcacagctgc aagcagggat gccggcatga gaagaacaag gcctggcacc   3900

tcggctcctg cagctgccgc agcagccctt cccccctcca cattgaaccc cacgtcgggg   3960

tcgctactca atgcagtgga tggaggcccc tcacatttct tggcctcagc cacagctgca   4020

gcacgtgccc agaggtcaga agtgagatat aaccagagat cccagacctc ccggaccaga   4080

tcctgcctca aacgaaatgc cagctccagc tcccacagct ctacggaagg cctccaggaa   4140

ctaaagcgga ggagggggcc agcctcatcc cactgccagc tggcccacag ttcctcaaac   4200

acagtgagtg aggacggacc tcaggctgtc tcttcgggtc accgctgtga aaacaaggca   4260

ggtacagcac cagggcagac actcgccccc aggggtggct accccagatc ccaggcctct   4320

aggccccgca tcaacagtgc actgcacgtt gaggacaagg ccatctcgga ctgcagaccc   4380

tcacggcctt cccacacttt gtcctcactt gcaacagggg cttcgggtgg gcctcccgtt   4440

tctaaagcac ccactatgga cgcacagcag gacagaccca agtcccaaga ctgcctgggc   4500

ctactggccc ccctagcatc tgctgcagag gtctcctcta cagctcccgt gtctgggaag   4560

aagcacagac caccaggacc cctgttctcc tcctcagatc cccttcctgc cacctcttcc   4620

cactcccggg actcagccca ggtcacctcg ctgattcctg ccaccttcac agctgcaagc   4680

agggatgccg gcatgagaag aacaaggcct ggcacctcgg ctcctgcagc tgccgcagca   4740

gcccttcccc cctccacatt gaaccccacg tcggggtcgc tactcaatgc agtggatgga   4800

ggcccctcac atttcttggc ctcagccaca gctgcagcac gtgcccagag gtcagaagtg   4860

agatataacc agagatccca gacctcccgg accagatcct gcctcaaacg aaatgccagc   4920

tccagctccc acagctctac ggaaggcctc caggaactaa agcggaggag ggggccagcc   4980

tcatcccact gccagctggc ccacagttcc tcaaacacag tgagtgagga cggacctcag   5040

gctgtctctt cgggtcaccg ctgtgaaaac aaggcaggta cagcaccagg gcagacactc   5100

gcccccaggg gtggctaccc cagatcccag gcctctaggc cccgcatcaa cagtgcactg   5160

cacgttgagg acaaggccat ctcggactgc agaccctcac ggccttccca cactttgtcc   5220

tcacttgcaa caggggcttc gggtgggcct cccgtttcta aagcacccac tatggatgca   5280

cagcaggaca gacccaagtc ccaagactgc ctgggcctac tggcccccct agcatctgct   5340

gcagaggtct cctctacagc tcccgtgtct gggaagaagc acagaccacc aggacccctg   5400

ttctcctcct cagatcccct tcctgccacc tcttcccact ccggggactc agcccaggac   5460

acctcgctga ttcctgcccc cttcacacct gcaagcaggg atgccggcat cagaagaatg   5520

tttcgtgttc gaaactgttt gaggggtttg ggtttatttt tgttggtttt ttcttttttt   5580

tttttgctta cgtgggcatc cttcagcttt taataatctg aaaaattcta tttacccatt   5640

gtcaatgtgt ataaattaat ctcagtcaat tttatacaat aaaaggtgaa cttttatcca   5700

tcaaacaata atttaacaaa aaatgtaccg gaagaagaat gttcattaca aatataggaa   5760

acataaatat taccaaatat tggcaagcac taaaatgttc agaaatataa gtctattaca   5820

gttatagctc tctcaagcaa aaaaacagca gagaaaaact tagttttcct gaggggctat   5880

ttatttactt agggatttgt taaaaggtca aatggggtca cacagaatac taagaagagc   5940

tgttcaccca ggcctcacta agaactcttc ttcatgcagt agctatatag taatatgaca   6000

actgctccta cgacccaaag aggaactaca gcaactactc tttagcatct gttgctccca   6060

actctgcttt gcaattatat gactcaagca ttctggctcc gttaactatt actgctgtta   6120

ctcccaagta aattccctct aaaaaataaa aatttttaaa gctgtaattt aagctctctg   6180

ctgcctcatg acttcaattc catcagagtt acgcattgtt tcctctgtac atctttgctc   6240

tgcttccatt gctaattccc tagtaaagtg ttgtatattc aaagttccaa agaaacagaa   6300

tatccaagac atcaccaatc atccaaaaca cagtgtagga ggccacagtt aagagaagca   6360

acaccattag ctctttttat aggctcgaga acaacaggat gctttggtcc tgtatcagca   6420

ggacgctttt tgggtagatc ctactgccac cctactatcg ggtagatcct actgtcaccc   6480

tagctatggg cacatgtcag agtcccatgt aataaaggag acaaaaggaa accaccacga   6540

gtataaacta agaaaagtac tccaaggttt ctaagaatgg agctgtataa ctcactttgc   6600

cccatttgtt acttctccac ggtacttacc accacctatt acatatattt tgtttatagt   6660

cagtcttccc ccattagaat gaaagttccg tgaggatagg actatacagt cagccctcag   6720

tatccatggg ggactggttt caggatctcc tgagggtaac aaaggatact caagtccctg   6780

atataaaatg acatagtatt tgcacatcac ctttgcacat cctcccatat acttcatatc   6840

aactctagat cactcataat atccgatgta aatgtcatgc aaatagttat tgtactatat   6900

tgtgtaagga ataaggacaa gaaaaaagtc tgtacatgtt cagtacagac gcaatttttt   6960

tttccaatat ttccaatcct tggttgcctt aacggatgta gaacccagga ataagttctg   7020

gtgtcctatt gcatagtagg atgagtatag ttaacaataa catattatat atttgaaaat   7080

agccagaaga gtagattttg aattttctcc ctacagaaaa atcattatgc aaattaccct   7140

gatttgatca ttacacattg agtacatgta ttaaaacatc acattctacc ccatatatat   7200

gtacagttat tatgtgtcca taaaaattta atgtcaatgt gtgaaataaa atgaaaaaat   7260

aaaaattttt aaagctgtaa ttatctccat ctggtaggaa tatatacaat ctgaaataaa   7320

aaatatattt gtaattgtta ggacaaaata gattatacgt taagtctgca aattataaat   7380

tataaaattc tcacagaacc tgaaaaatta ttgatactgt taaatattta aaaagctgtc   7440

cttggagaga aagaaaccta tcagatttac atcaacaagt gtaatatgtc agcctattac   7500

catctgctac agactgcatg tttgtgttcc ctcaaaattc atatgatagg ccgggcgcgg   7560

tggc                                                                7564


<210>  1030
<211>  1438
<212>  PRT
<213>  Homosapiens

<400>  1030

Met Pro Glu Gln Asp Lys Asp Pro Arg Val Gln Glu Asn Pro Asp Asp 
1               5                   10                  15      


Gln Arg Thr Val Pro Glu Val Thr Gly Asp Ala Arg Ser Ala Phe Trp 
            20                  25                  30          


Pro Leu Arg Asp Asn Gly Gly Pro Ser Pro Phe Val Pro Arg Pro Gly 
        35                  40                  45              


Pro Leu Gln Thr Asp Leu His Ala Gln Ser Ser Glu Ile Arg Tyr Asn 
    50                  55                  60                  


His Thr Ser Gln Thr Ser Trp Thr Ser Ser Ser Thr Lys Arg Asn Ala 
65                  70                  75                  80  


Ile Ser Ser Ser Tyr Ser Ser Thr Gly Gly Leu Pro Gly Leu Lys Gln 
                85                  90                  95      


Arg Arg Gly Pro Ala Ser Ser Arg Cys Gln Leu Thr Leu Ser Tyr Ser 
            100                 105                 110         


Lys Thr Val Ser Glu Asp Arg Pro Gln Ala Val Ser Ser Gly His Thr 
        115                 120                 125             


Arg Cys Glu Lys Gly Ala Asp Thr Ala Pro Gly Gln Thr Ile Ala Pro 
    130                 135                 140                 


Thr Gly Gly Ser Pro Arg Ser Gln Asp Ser Arg Pro Arg Arg Arg Lys 
145                 150                 155                 160 


Ile Pro Leu Leu Pro Arg Arg Arg Gly Glu Pro Leu Met Leu Pro Pro 
                165                 170                 175     


Pro Leu Glu Leu Gly Tyr Arg Val Thr Ala Glu Asp Leu His Leu Glu 
            180                 185                 190         


Lys Glu Thr Ala Phe Gln Arg Ile Asn Ser Ala Leu His Val Glu Asp 
        195                 200                 205             


Lys Ala Ile Pro Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser 
    210                 215                 220                 


Ser Leu Ala Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro 
225                 230                 235                 240 


Thr Met Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly 
                245                 250                 255     


Leu Val Ala Pro Leu Ala Ser Ala Ala Glu Val Pro Ala Thr Ala Pro 
            260                 265                 270         


Val Ser Gly Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser 
        275                 280                 285             


Asp Pro Leu Pro Ala Asn Ser Ser His Ser Arg Asp Ser Ala Gln Val 
    290                 295                 300                 


Thr Ser Met Ile Pro Ala Pro Phe Thr Ala Ala Ser Arg Asp Ala Gly 
305                 310                 315                 320 


Met Arg Arg Thr Arg Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro 
                325                 330                 335     


Pro Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp 
            340                 345                 350         


Gly Gly Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala 
        355                 360                 365             


Gln Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr 
    370                 375                 380                 


Arg Ser Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr 
385                 390                 395                 400 


Glu Gly Leu Gln Glu Val Lys Arg Arg Arg Gly Pro Ala Ser Ser His 
                405                 410                 415     


Cys Gln Leu Ala Leu Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro 
            420                 425                 430         


Gln Ala Val Ser Ser Gly His His Cys Glu Asn Lys Ala Gly Thr Ala 
        435                 440                 445             


Pro Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala 
    450                 455                 460                 


Ser Arg Pro His Ile Asn Thr Ala Leu His Val Glu Asp Lys Ala Ile 
465                 470                 475                 480 


Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala 
                485                 490                 495     


Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp 
            500                 505                 510         


Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Ser Leu Gly Leu Leu Ala 
        515                 520                 525             


Pro Leu Ala Ser Ala Ala Glu Val Pro Ser Thr Ala Pro Val Ser Gly 
    530                 535                 540                 


Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu 
545                 550                 555                 560 


Pro Ala Thr Ser Tyr His Ser Arg Asp Thr Ala Gln Val Thr Ser Leu 
                565                 570                 575     


Ile Pro Ala Thr Phe Thr Ala Ala Ser Arg Asp Ala Gly Met Arg Arg 
            580                 585                 590         


Thr Arg Ser Ala Pro Ala Ala Ala Thr Ala Ala Pro Pro Pro Ser Thr 
        595                 600                 605             


Leu Asn Asn Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Gly Gly Pro 
    610                 615                 620                 


Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala Gln Arg Ser 
625                 630                 635                 640 


Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg Ser Cys 
                645                 650                 655     


Leu Lys Arg Asn Ala Ser Ser Ser Ser Ser Ser His Ser Ser Thr Glu 
            660                 665                 670         


Gly Leu Gln Glu Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser His Cys 
        675                 680                 685             


Gln Leu Ala His Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro Gln 
    690                 695                 700                 


Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala Pro 
705                 710                 715                 720 


Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala Ser 
                725                 730                 735     


Arg Pro His Ile Asn Ser Ala Leu Tyr Val Glu Asp Lys Ala Ile Ser 
            740                 745                 750         


Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala Thr 
        755                 760                 765             


Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp Ala 
    770                 775                 780                 


Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly Leu Val Ala Pro 
785                 790                 795                 800 


Leu Ala Ser Ala Ala Glu Val Pro Ser Thr Ala Pro Val Ser Gly Lys 
                805                 810                 815     


Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu Pro 
            820                 825                 830         


Ala Thr Ser Ser His Ser Arg Asp Ser Ala Gln Val Thr Ser Leu Ile 
        835                 840                 845             


Pro Ala Thr Phe Thr Ala Ala Ser Arg Asp Ala Gly Met Arg Arg Thr 
    850                 855                 860                 


Arg Pro Gly Thr Ser Ala Pro Ala Ala Ala Ala Ala Ala Leu Pro Pro 
865                 870                 875                 880 


Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Gly 
                885                 890                 895     


Gly Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala Gln 
            900                 905                 910         


Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg 
        915                 920                 925             


Ser Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr Glu 
    930                 935                 940                 


Gly Leu Gln Glu Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser His Cys 
945                 950                 955                 960 


Gln Leu Ala His Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro Gln 
                965                 970                 975     


Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala Pro 
            980                 985                 990         


Gly Gln Thr Leu Ala Pro Arg Gly  Gly Tyr Pro Arg Ser  Gln Ala Ser 
        995                 1000                 1005             


Arg Pro  Arg Ile Asn Ser Ala  Leu His Val Glu Asp  Lys Ala Ile 
    1010                 1015                 1020             


Ser Asp  Cys Arg Pro Ser Arg  Pro Ser His Thr Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ala Thr  Gly Ala Ser Gly Gly  Pro Pro Val Ser Lys  Ala Pro Thr 
    1040                 1045                 1050             


Met Asp  Ala Gln Gln Asp Arg  Pro Lys Ser Gln Asp  Cys Leu Gly 
    1055                 1060                 1065             


Leu Leu  Ala Pro Leu Ala Ser  Ala Ala Glu Val Ser  Ser Thr Ala 
    1070                 1075                 1080             


Pro Val  Ser Gly Lys Lys His  Arg Pro Pro Gly Pro  Leu Phe Ser 
    1085                 1090                 1095             


Ser Ser  Asp Pro Leu Pro Ala  Thr Ser Ser His Ser  Arg Asp Ser 
    1100                 1105                 1110             


Ala Gln  Val Thr Ser Leu Ile  Pro Ala Thr Phe Thr  Ala Ala Ser 
    1115                 1120                 1125             


Arg Asp  Ala Gly Met Arg Arg  Thr Arg Pro Gly Thr  Ser Ala Pro 
    1130                 1135                 1140             


Ala Ala  Ala Ala Ala Ala Leu  Pro Pro Ser Thr Leu  Asn Pro Thr 
    1145                 1150                 1155             


Ser Gly  Ser Leu Leu Asn Ala  Val Asp Gly Gly Pro  Ser His Phe 
    1160                 1165                 1170             


Leu Ala  Ser Ala Thr Ala Ala  Ala Arg Ala Gln Arg  Ser Glu Val 
    1175                 1180                 1185             


Arg Tyr  Asn Gln Arg Ser Gln  Thr Ser Arg Thr Arg  Ser Cys Leu 
    1190                 1195                 1200             


Lys Arg  Asn Ala Ser Ser Ser  Ser His Ser Ser Thr  Glu Gly Leu 
    1205                 1210                 1215             


Gln Glu  Leu Lys Arg Arg Arg  Gly Pro Ala Ser Ser  His Cys Gln 
    1220                 1225                 1230             


Leu Ala  His Ser Ser Ser Asn  Thr Val Ser Glu Asp  Gly Pro Gln 
    1235                 1240                 1245             


Ala Val  Ser Ser Gly His Arg  Cys Glu Asn Lys Ala  Gly Thr Ala 
    1250                 1255                 1260             


Pro Gly  Gln Thr Leu Ala Pro  Arg Gly Gly Tyr Pro  Arg Ser Gln 
    1265                 1270                 1275             


Ala Ser  Arg Pro Arg Ile Asn  Ser Ala Leu His Val  Glu Asp Lys 
    1280                 1285                 1290             


Ala Ile  Ser Asp Cys Arg Pro  Ser Arg Pro Ser His  Thr Leu Ser 
    1295                 1300                 1305             


Ser Leu  Ala Thr Gly Ala Ser  Gly Gly Pro Pro Val  Ser Lys Ala 
    1310                 1315                 1320             


Pro Thr  Met Asp Ala Gln Gln  Asp Arg Pro Lys Ser  Gln Asp Cys 
    1325                 1330                 1335             


Leu Gly  Leu Leu Ala Pro Leu  Ala Ser Ala Ala Glu  Val Ser Ser 
    1340                 1345                 1350             


Thr Ala  Pro Val Ser Gly Lys  Lys His Arg Pro Pro  Gly Pro Leu 
    1355                 1360                 1365             


Phe Ser  Ser Ser Asp Pro Leu  Pro Ala Thr Ser Ser  His Ser Gly 
    1370                 1375                 1380             


Asp Ser  Ala Gln Asp Thr Ser  Leu Ile Pro Ala Pro  Phe Thr Pro 
    1385                 1390                 1395             


Ala Ser  Arg Asp Ala Gly Ile  Arg Arg Met Phe Arg  Val Arg Asn 
    1400                 1405                 1410             


Cys Leu  Arg Gly Leu Gly Leu  Phe Leu Leu Val Phe  Ser Phe Phe 
    1415                 1420                 1425             


Phe Leu  Leu Thr Trp Ala Ser  Phe Ser Phe 
    1430                 1435             


<210>  1031
<211>  6748
<212>  DNA
<213>  Homosapiens

<400>  1031
ttatatggtt tggctctgtc cgcacccaaa tctcatcttg aattgtaaca attcccatgt     60

gtcaagggtg gggccaggtg gagataactg aatcatggag gcagtttccc ccatgctgtt    120

ctcatggtag tgaataagtc tcatgaggtc tgatggtttt ataaatggat gttcccctgc    180

acatgctctc tcctgcccac catgtctgac taaattttgt atttttacta gagacgggct    240

ttcactatgt tggccaggct ggcctccaac tcctgatctc gtgatccgtc caccccgacc    300

tcccaaagtg ctaggatcat aggcataagc caccacaccc ggcctctttt ttttcttttt    360

ctttttttta tctggagact gagttttgca ctcgttgccc aggctggagt gcaatggtgc    420

gatctcagct cactgcagtc tccacctcag caggagagca ggaatcttca gtgatccacg    480

ggcaaatatg cagccattgt gggcacctgt tcctcccgcg acctttgtgc ccacgtctct    540

ccctccagta cctactgcac gaccccccac gtccgcctcc tgccattgcc agcaggtgcc    600

ttgcgcgggt acctggctgt gcttattcat ccattatggt cgctctgtca ctggtgccat    660

tatgtgctca catgcccact ccctcaggtt tagaagtcgc gttgcccggc aacagaacaa    720

tctgctggct tagcctttgg ccaagttggc agctggacga ggacgctcag agcccagctc    780

ttgagagttc aagtatccga cagttcccca ctgctcccag gagcggttac ccgggcactc    840

tgtgcccctc attcctgttt gggccaaggc cgaggacctg cgagtagggc tcagttgcct    900

ggagcccctt cagcccatcc cccagttcac tttgcttgtg ggatctcccc gttgctcctg    960

cccctggact gagtggcagg ccatcctaca aacacccgca cactcgacat cagtggtgtc   1020

aagacaactc taagaaggtt ttccgtgatc ctgcaagacc tgtgttccat cctggtgatt   1080

ctgtcttcaa tttcactgca caggtaccac agtaagccag tgctgtgtgc tccgagttcc   1140

agggcatccc ccagctcagc cactacactg agcacaagga ctctgtgggg cccaggagca   1200

ggtagtcacc cctttggggt ccacaacacc cggctgtccc cagacttgtg tccagggaag   1260

atagtgttga gggccctcaa ggagagcggg gcagggatgc ctgagcagga caaggacccc   1320

agagtccaag aaaatcctga tgatcagaga acggtccccg aggtcaccgg ggatgcacgg   1380

tctgcatttt ggcccctgcg ggacaatgga ggcccctctc cctttgtgcc caggcccggg   1440

cctctgcaga cagacctcca cgcccagagc tcagaaatca gatataacca cacatcccag   1500

acatcctgga cgagctcgag caccaaacga aatgccatct ccagctccta cagctccacg   1560

ggaggcttgc cggggctaaa gcagaggagg gggccagcct catcccgctg ccagctgacc   1620

ctcagttact caaagacagt gagtgaggac aggcctcagg ctgtctcttc gggtcacaca   1680

cggtgtgaaa agggggcaga tacagcacca gggcagacaa tcgccccaac gggtggctcc   1740

cccagatccc aggactctag gccccgtaga cgcaagattc ccctgctgcc acgcaggcga   1800

ggggagcctt tgatgctgcc acctccctta gagctggggt accgggtcac ggctgaagac   1860

ctgcacctgg aaaaagagac ggcattccag cgcatcaaca gtgcactgca cgttgaggac   1920

aaggccatcc cggactgcag accctcacgg ccttcccaca ctttgtcctc acttgcaaca   1980

ggggcttcgg gtgggcctcc cgtttctaaa gcacccacta tggatgcaca gcaggacaga   2040

cccaagtccc aagactgcct gggcctagtg gcccccctag catctgctgc agaggtcccc   2100

gctacagctc ccgtgtctgg gaagaagcac agaccaccag gacccctgtt ctcctcctca   2160

gatccccttc ctgccaactc ttcccactcc cgggactcag cccaggtcac ctcgatgatt   2220

cctgccccct tcacagctgc aagcagggat gccggcatga gaagaacaag gtcggctcct   2280

gcagctgccg cagcagcccc tcccccctcc acattgaacc ccacgtcggg gtcactactc   2340

aatgcagtgg atggaggccc ctcacatttc ttggcctcag ccacagctgc agcacgtgcc   2400

cagaggtcag aagtgagata taaccagaga tcccagacct cccggaccag atcctgcctc   2460

aaacgaaatg ccagctccag ctcccacagc tctacggaag gcctccagga agtaaagcgg   2520

aggagggggc cagcctcatc ccactgccag ctggccctca gttcctcaaa cacagtgagt   2580

gaggacggac ctcaggctgt ctcttcgggt caccactgtg aaaacaaggc aggtacagca   2640

ccagggcaga cacttgcccc caggggtggc tcccccagat cccaggcctc taggccccac   2700

atcaacactg cactgcacgt tgaggacaag gccatctcgg actgcagacc ctcacggcct   2760

tcccacactt tgtcctcact tgcaacaggg gcttcgggtg ggcctcccgt ttctaaagca   2820

cccactatgg atgcacagca ggacagaccc aagtcccaag actccctggg cctactggcc   2880

cccctagcat ctgctgcaga ggtcccctct acagctcccg tgtctgggaa gaagcacaga   2940

ccaccaggac ccctgttctc ctcctcagat ccccttcctg ccacctctta ccactcccgg   3000

gacacagcac aggtcacctc gctgattcct gccaccttca cagctgcaag cagggatgcc   3060

ggcatgagaa gaacaaggtc ggctcctgca gctgccacag cagcccctcc cccctccaca   3120

ttgaacaaca cgtcggggtc actactcaat gcagtggatg gaggcccctc acatttcttg   3180

gcctcagcca cagctgcagc acgtgcccag aggtcagaag tgagatataa ccagagatcc   3240

cagacctccc ggaccagatc ctgcctcaaa cgaaatgcca gctccagctc cagctcccac   3300

agctctacgg aaggcctcca ggaactaaag cggaggaggg ggccagcctc atcccactgc   3360

cagctggccc acagttcctc aaacacagtg agtgaggacg gacctcaggc tgtctcttcg   3420

ggtcaccgct gtgaaaacaa ggcaggtaca gcaccagggc agacactcgc ccccagggga   3480

ggctccccca gatcccaggc ctctaggccc cacatcaaca gtgcactgta cgttgaggac   3540

aaggccatct cggactgcag accctcacgg ccttcccaca ctttgtcctc acttgcaaca   3600

ggggcttcgg gtgggcctcc cgtttctaaa gcacccacta tggacgcaca gcaggacaga   3660

cccaagtccc aagactgcct gggcctagtg gcccccctag catctgctgc agaggtcccc   3720

tctacagctc ccgtgtctgg gaagaagcac agaccaccag gacccctgtt ctcctcctca   3780

gatccccttc ctgccacctc ttcccactcc cgggactcag cccaggtcac ctcgctgatt   3840

cctgccacct tcacagctgc aagcagggat gccggcatga gaagaacaag gcctggcacc   3900

tcggctcctg cagctgccgc agcagccctt cccccctcca cattgaaccc cacgtcgggg   3960

tcgctactca atgcagtgga tggaggcccc tcacatttct tggcctcagc cacagctgca   4020

gcacgtgccc agaggtcaga agtgagatat aaccagagat cccagacctc ccggaccaga   4080

tcctgcctca aacgaaatgc cagctccagc tcccacagct ctacggaagg cctccaggaa   4140

ctaaagcgga ggagggggcc agcctcatcc cactgccagc tggcccacag ttcctcaaac   4200

acagtgagtg aggacggacc tcaggctgtc tcttcgggtc accgctgtga aaacaaggca   4260

ggtacagcac cagggcagac actcgccccc aggggtggct accccagatc ccaggcctct   4320

aggccccgca tcaacagtgc actgcacgtt gaggacaagg ccatctcgga ctgcagaccc   4380

tcacggcctt cccacacttt gtcctcactt gcaacagggg cttcgggtgg gcctcccgtt   4440

tctaaagcac ccactatgga tgcacagcag gacagaccca agtcccaaga ctgcctgggc   4500

ctactggccc ccctagcatc tgctgcagag gtctcctcta cagctcccgt gtctgggaag   4560

aagcacagac caccaggacc cctgttctcc tcctcagatc cccttcctgc cacctcttcc   4620

cactccgggg actcagccca ggacacctcg ctgattcctg cccccttcac acctgcaagc   4680

agggatgccg gcatcagaag aatgtttcgt gttcgaaact gtttgagggg tttgggttta   4740

tttttgttgg ttttttcttt tttttttttg cttacgtggg catccttcag cttttaataa   4800

tctgaaaaat tctatttacc cattgtcaat gtgtataaat taatctcagt caattttata   4860

caataaaagg tgaactttta tccatcaaac aataatttaa caaaaaatgt accggaagaa   4920

gaatgttcat tacaaatata ggaaacataa atattaccaa atattggcaa gcactaaaat   4980

gttcagaaat ataagtctat tacagttata gctctctcaa gcaaaaaaac agcagagaaa   5040

aacttagttt tcctgagggg ctatttattt acttagggat ttgttaaaag gtcaaatggg   5100

gtcacacaga atactaagaa gagctgttca cccaggcctc actaagaact cttcttcatg   5160

cagtagctat atagtaatat gacaactgct cctacgaccc aaagaggaac tacagcaact   5220

actctttagc atctgttgct cccaactctg ctttgcaatt atatgactca agcattctgg   5280

ctccgttaac tattactgct gttactccca agtaaattcc ctctaaaaaa taaaaatttt   5340

taaagctgta atttaagctc tctgctgcct catgacttca attccatcag agttacgcat   5400

tgtttcctct gtacatcttt gctctgcttc cattgctaat tccctagtaa agtgttgtat   5460

attcaaagtt ccaaagaaac agaatatcca agacatcacc aatcatccaa aacacagtgt   5520

aggaggccac agttaagaga agcaacacca ttagctcttt ttataggctc gagaacaaca   5580

ggatgctttg gtcctgtatc agcaggacgc tttttgggta gatcctactg ccaccctact   5640

atcgggtaga tcctactgtc accctagcta tgggcacatg tcagagtccc atgtaataaa   5700

ggagacaaaa ggaaaccacc acgagtataa actaagaaaa gtactccaag gtttctaaga   5760

atggagctgt ataactcact ttgccccatt tgttacttct ccacggtact taccaccacc   5820

tattacatat attttgttta tagtcagtct tcccccatta gaatgaaagt tccgtgagga   5880

taggactata cagtcagccc tcagtatcca tgggggactg gtttcaggat ctcctgaggg   5940

taacaaagga tactcaagtc cctgatataa aatgacatag tatttgcaca tcacctttgc   6000

acatcctccc atatacttca tatcaactct agatcactca taatatccga tgtaaatgtc   6060

atgcaaatag ttattgtact atattgtgta aggaataagg acaagaaaaa agtctgtaca   6120

tgttcagtac agacgcaatt tttttttcca atatttccaa tccttggttg ccttaacgga   6180

tgtagaaccc aggaataagt tctggtgtcc tattgcatag taggatgagt atagttaaca   6240

ataacatatt atatatttga aaatagccag aagagtagat tttgaatttt ctccctacag   6300

aaaaatcatt atgcaaatta ccctgatttg atcattacac attgagtaca tgtattaaaa   6360

catcacattc taccccatat atatgtacag ttattatgtg tccataaaaa tttaatgtca   6420

atgtgtgaaa taaaatgaaa aaataaaaat ttttaaagct gtaattatct ccatctggta   6480

ggaatatata caatctgaaa taaaaaatat atttgtaatt gttaggacaa aatagattat   6540

acgttaagtc tgcaaattat aaattataaa attctcacag aacctgaaaa attattgata   6600

ctgttaaata tttaaaaagc tgtccttgga gagaaagaaa cctatcagat ttacatcaac   6660

aagtgtaata tgtcagccta ttaccatctg ctacagactg catgtttgtg ttccctcaaa   6720

attcatatga taggccgggc gcggtggc                                      6748


<210>  1032
<211>  1166
<212>  PRT
<213>  Homosapiens

<400>  1032

Met Pro Glu Gln Asp Lys Asp Pro Arg Val Gln Glu Asn Pro Asp Asp 
1               5                   10                  15      


Gln Arg Thr Val Pro Glu Val Thr Gly Asp Ala Arg Ser Ala Phe Trp 
            20                  25                  30          


Pro Leu Arg Asp Asn Gly Gly Pro Ser Pro Phe Val Pro Arg Pro Gly 
        35                  40                  45              


Pro Leu Gln Thr Asp Leu His Ala Gln Ser Ser Glu Ile Arg Tyr Asn 
    50                  55                  60                  


His Thr Ser Gln Thr Ser Trp Thr Ser Ser Ser Thr Lys Arg Asn Ala 
65                  70                  75                  80  


Ile Ser Ser Ser Tyr Ser Ser Thr Gly Gly Leu Pro Gly Leu Lys Gln 
                85                  90                  95      


Arg Arg Gly Pro Ala Ser Ser Arg Cys Gln Leu Thr Leu Ser Tyr Ser 
            100                 105                 110         


Lys Thr Val Ser Glu Asp Arg Pro Gln Ala Val Ser Ser Gly His Thr 
        115                 120                 125             


Arg Cys Glu Lys Gly Ala Asp Thr Ala Pro Gly Gln Thr Ile Ala Pro 
    130                 135                 140                 


Thr Gly Gly Ser Pro Arg Ser Gln Asp Ser Arg Pro Arg Arg Arg Lys 
145                 150                 155                 160 


Ile Pro Leu Leu Pro Arg Arg Arg Gly Glu Pro Leu Met Leu Pro Pro 
                165                 170                 175     


Pro Leu Glu Leu Gly Tyr Arg Val Thr Ala Glu Asp Leu His Leu Glu 
            180                 185                 190         


Lys Glu Thr Ala Phe Gln Arg Ile Asn Ser Ala Leu His Val Glu Asp 
        195                 200                 205             


Lys Ala Ile Pro Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser 
    210                 215                 220                 


Ser Leu Ala Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro 
225                 230                 235                 240 


Thr Met Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly 
                245                 250                 255     


Leu Val Ala Pro Leu Ala Ser Ala Ala Glu Val Pro Ala Thr Ala Pro 
            260                 265                 270         


Val Ser Gly Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser 
        275                 280                 285             


Asp Pro Leu Pro Ala Asn Ser Ser His Ser Arg Asp Ser Ala Gln Val 
    290                 295                 300                 


Thr Ser Met Ile Pro Ala Pro Phe Thr Ala Ala Ser Arg Asp Ala Gly 
305                 310                 315                 320 


Met Arg Arg Thr Arg Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro 
                325                 330                 335     


Pro Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp 
            340                 345                 350         


Gly Gly Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala 
        355                 360                 365             


Gln Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr 
    370                 375                 380                 


Arg Ser Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr 
385                 390                 395                 400 


Glu Gly Leu Gln Glu Val Lys Arg Arg Arg Gly Pro Ala Ser Ser His 
                405                 410                 415     


Cys Gln Leu Ala Leu Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro 
            420                 425                 430         


Gln Ala Val Ser Ser Gly His His Cys Glu Asn Lys Ala Gly Thr Ala 
        435                 440                 445             


Pro Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala 
    450                 455                 460                 


Ser Arg Pro His Ile Asn Thr Ala Leu His Val Glu Asp Lys Ala Ile 
465                 470                 475                 480 


Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala 
                485                 490                 495     


Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp 
            500                 505                 510         


Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Ser Leu Gly Leu Leu Ala 
        515                 520                 525             


Pro Leu Ala Ser Ala Ala Glu Val Pro Ser Thr Ala Pro Val Ser Gly 
    530                 535                 540                 


Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu 
545                 550                 555                 560 


Pro Ala Thr Ser Tyr His Ser Arg Asp Thr Ala Gln Val Thr Ser Leu 
                565                 570                 575     


Ile Pro Ala Thr Phe Thr Ala Ala Ser Arg Asp Ala Gly Met Arg Arg 
            580                 585                 590         


Thr Arg Ser Ala Pro Ala Ala Ala Thr Ala Ala Pro Pro Pro Ser Thr 
        595                 600                 605             


Leu Asn Asn Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Gly Gly Pro 
    610                 615                 620                 


Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala Gln Arg Ser 
625                 630                 635                 640 


Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg Ser Cys 
                645                 650                 655     


Leu Lys Arg Asn Ala Ser Ser Ser Ser Ser Ser His Ser Ser Thr Glu 
            660                 665                 670         


Gly Leu Gln Glu Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser His Cys 
        675                 680                 685             


Gln Leu Ala His Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro Gln 
    690                 695                 700                 


Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala Pro 
705                 710                 715                 720 


Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala Ser 
                725                 730                 735     


Arg Pro His Ile Asn Ser Ala Leu Tyr Val Glu Asp Lys Ala Ile Ser 
            740                 745                 750         


Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala Thr 
        755                 760                 765             


Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp Ala 
    770                 775                 780                 


Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly Leu Val Ala Pro 
785                 790                 795                 800 


Leu Ala Ser Ala Ala Glu Val Pro Ser Thr Ala Pro Val Ser Gly Lys 
                805                 810                 815     


Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu Pro 
            820                 825                 830         


Ala Thr Ser Ser His Ser Arg Asp Ser Ala Gln Val Thr Ser Leu Ile 
        835                 840                 845             


Pro Ala Thr Phe Thr Ala Ala Ser Arg Asp Ala Gly Met Arg Arg Thr 
    850                 855                 860                 


Arg Pro Gly Thr Ser Ala Pro Ala Ala Ala Ala Ala Ala Leu Pro Pro 
865                 870                 875                 880 


Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Gly 
                885                 890                 895     


Gly Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala Gln 
            900                 905                 910         


Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg 
        915                 920                 925             


Ser Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr Glu 
    930                 935                 940                 


Gly Leu Gln Glu Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser His Cys 
945                 950                 955                 960 


Gln Leu Ala His Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro Gln 
                965                 970                 975     


Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala Pro 
            980                 985                 990         


Gly Gln Thr Leu Ala Pro Arg Gly  Gly Tyr Pro Arg Ser  Gln Ala Ser 
        995                 1000                 1005             


Arg Pro  Arg Ile Asn Ser Ala  Leu His Val Glu Asp  Lys Ala Ile 
    1010                 1015                 1020             


Ser Asp  Cys Arg Pro Ser Arg  Pro Ser His Thr Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ala Thr  Gly Ala Ser Gly Gly  Pro Pro Val Ser Lys  Ala Pro Thr 
    1040                 1045                 1050             


Met Asp  Ala Gln Gln Asp Arg  Pro Lys Ser Gln Asp  Cys Leu Gly 
    1055                 1060                 1065             


Leu Leu  Ala Pro Leu Ala Ser  Ala Ala Glu Val Ser  Ser Thr Ala 
    1070                 1075                 1080             


Pro Val  Ser Gly Lys Lys His  Arg Pro Pro Gly Pro  Leu Phe Ser 
    1085                 1090                 1095             


Ser Ser  Asp Pro Leu Pro Ala  Thr Ser Ser His Ser  Gly Asp Ser 
    1100                 1105                 1110             


Ala Gln  Asp Thr Ser Leu Ile  Pro Ala Pro Phe Thr  Pro Ala Ser 
    1115                 1120                 1125             


Arg Asp  Ala Gly Ile Arg Arg  Met Phe Arg Val Arg  Asn Cys Leu 
    1130                 1135                 1140             


Arg Gly  Leu Gly Leu Phe Leu  Leu Val Phe Ser Phe  Phe Phe Leu 
    1145                 1150                 1155             


Leu Thr  Trp Ala Ser Phe Ser  Phe 
    1160                 1165     


<210>  1033
<211>  6133
<212>  DNA
<213>  Homosapiens

<400>  1033
tgcatgaaga caaaaggtcc tgtgctcacc tgggaccctt ctggacgttg ccctgtgtac     60

ctcttcgact gcctgttcat ctacgacgaa ccccgggtat tgaccccaga caacaatgcc    120

acttcatatt ggggacttcg tctgggattc caaggtgcat tcattgcaaa gttccttaaa    180

tattttctca ctgcttccta ctaaaggacg gacagagcat ttgttcttca gccacatact    240

ttccttccac tggccagcat tctcctctat tagactagaa ctgtggataa acctcagaaa    300

atggccaccc agcagaaagc ctctgacgag aggatctccc agtttgatca caatttgctg    360

ccagagctgt ctgctcttct gggcctagat gcagttcagt tggcaaagga actagaagaa    420

gaggagcaga aggagcgagc aaaaatgcag aaaggctaca actctcaaat gcgcagtgaa    480

gcaaaaaggt taaagacttt tgtgacttat gagccgtaca gctcatggat accacaggag    540

atggcggccg ctgggtttta cttcactggg gtaaaatctg ggattcagtg cttctgctgt    600

agcctaatcc tctttggtgc cggcctcacg agactcccca tagaagacca caagaggttt    660

catccagatt gtgggttcct tttgaacaag gatgttggta acattgccaa gtacgacata    720

agggtgaaga atctgaagag caggctgaga ggaggtaaaa tgaggtacca agaagaggag    780

gctagacttg cgtccttcag gaactggcca ttttatgtcc aagggatatc cccttgtgtg    840

ctctcagagg ctggctttgt ctttacaggt aaacaggaca cggtacagtg tttttcctgt    900

ggtggatgtt taggaaattg ggaagaagga gatgatcctt ggaaggaaca tgccaaatgg    960

ttccccaaat gtgaatttct tcggagtaag aaatcctcag aggaaattac ccagtatatt   1020

caaagctaca agggatttgt tgacataacg ggagaacatt ttgtgaattc ctgggtccag   1080

agagaattac ctatggcatc agcttattgc aatgacagca tctttgctta cgaagaacta   1140

cggctggact cttttaagga ctggccccgg gaatcagctg tgggagttgc agcactggcc   1200

aaagcaggtc ttttctacac aggtataaag gacatcgtcc agtgcttttc ctgtggaggg   1260

tgtttagaga aatggcagga aggtgatgac ccattagacg atcacaccag atgttttccc   1320

aattgtccat ttctccaaaa tatgaagtcc tctgcggaag tgactccaga ccttcagagc   1380

cgtggtgaac tttgtgaatt actggaaacc acaagtgaaa gcaatcttga agattcaata   1440

gcagttggtc ctatagtgcc agaaatggca cagggtgaag cccagtggtt tcaagaggca   1500

aagaatctga atgagcagct gagagcagct tataccagcg ccagtttccg ccacatgtct   1560

ttgcttgata tctcttccga tctggccacg gaccacttgc tgggctgtga tctgtctatt   1620

gcttcaaaac acatcagcaa acctgtgcaa gaacctctgg tgctgcctga ggtctttggc   1680

aacttgaact ctgtcatgtg tgtggagggt gaagctggaa gtggaaagac ggtcctcctg   1740

aagaaaatag cttttctgtg ggcatctgga tgctgtcccc tgttaaacag gttccagctg   1800

gttttctacc tctcccttag ttccaccaga ccagacgagg ggctggccag tatcatctgt   1860

gaccagctcc tagagaaaga aggatctgtt actgaaatgt gcatgaggaa cattatccag   1920

cagttaaaga atcaggtctt attcctttta gatgactaca aagaaatatg ttcaatccct   1980

caagtcatag gaaaactgat tcaaaaaaac cacttatccc ggacctgcct attgattgct   2040

gtccgtacaa acagggccag ggacatccgc cgatacctag agaccattct agagatcaaa   2100

gcatttccct tttataatac tgtctgtata ttacggaagc tcttttcaca taatatgact   2160

cgtctgcgaa agtttatggt ttactttgga aagaaccaaa gtttgcagaa gatacagaaa   2220

actcctctct ttgtggcggc gatctgtgct cattggtttc agtatccttt tgacccatcc   2280

tttgatgatg tggctgtttt caagtcctat atggaacgcc tttccttaag gaacaaagcg   2340

acagctgaaa ttctcaaagc aactgtgtcc tcctgtggtg agctggcctt gaaagggttt   2400

ttttcatgtt gctttgagtt taatgatgat gatctcgcag aagcaggggt tgatgaagat   2460

gaagatctaa ccatgtgctt gatgagcaaa tttacagccc agagactaag accattctac   2520

cggtttttaa gtcctgcctt ccaagaattt cttgcgggga tgaggctgat tgaactcctg   2580

gattcagata ggcaggaaca tcaagatttg ggactgtatc atttgaaaca aatcaactca   2640

cccatgatga ctgtaagcgc ctacaacaat tttttgaact atgtctccag cctcccttca   2700

acaaaagcag ggcccaaaat tgtgtctcat ttgctccatt tagtggataa caaagagtca   2760

ttggagaata tatctgaaaa tgatgactac ttaaagcacc agccagaaat ttcactgcag   2820

atgcagttac ttaggggatt gtggcaaatt tgtccacaag cttacttttc aatggtttca   2880

gaacatttac tggttcttgc cctgaaaact gcttatcaaa gcaacactgt tgctgcgtgt   2940

tctccatttg ttttgcaatt ccttcaaggg agaacactga ctttgggtgc gcttaactta   3000

cagtactttt tcgaccaccc agaaagcttg tcattgttga ggagcatcca cttcccaata   3060

cgaggaaata agacatcacc cagagcacat ttttcagttc tggaaacatg ttttgacaaa   3120

tcacaggtgc caactataga tcaggactat gcttctgcct ttgaacctat gaatgaatgg   3180

gagcgaaatt tagctgaaaa agaggataat gtaaagagct atatggatat gcagcgcagg   3240

gcatcaccag accttagtac tggctattgg aaactttctc caaagcagta caagattccc   3300

tgtctagaag tcgatgtgaa tgatattgat gttgtaggcc aggatatgct tgagattcta   3360

atgacagttt tctcagcttc acagcgcatc gaactccatt taaaccacag cagaggcttt   3420

atagaaagca tccgcccagc tcttgagctg tctaaggcct ctgtcaccaa gtgctccata   3480

agcaagttgg aactcagcgc agccgaacag gaactgcttc tcaccctgcc ttccctggaa   3540

tctcttgaag tctcagggac aatccagtca caagaccaaa tctttcctaa tctggataag   3600

ttcctgtgcc tgaaagaact gtctgtggat ctggagggca atataaatgt tttttcagtc   3660

attcctgaag aatttccaaa cttccaccat atggagaaat tattgatcca aatttcagct   3720

gagtatgatc cttccaaact agtaaaatta attcaaaatt ctccaaacct tcatgttttc   3780

catctgaagt gtaacttctt ttcggatttt gggtctctca tgactatgct tgtttcctgt   3840

aagaaactca cagaaattaa gttttcggat tcattttttc aagccgtccc atttgttgcc   3900

agtttgccaa attttatttc tctgaagata ttaaatcttg aaggccagca atttcctgat   3960

gaggaaacat cagaaaaatt tgcctacatt ttaggttctc ttagtaacct ggaagaattg   4020

atccttccta ctggggatgg aatttatcga gtggccaaac tgatcatcca gcagtgtcag   4080

cagcttcatt gtctccgagt cctctcattt ttcaagactt tgaatgatga cagcgtggtg   4140

gaaattgcca aagtagcaat cagtggaggt ttccagaaac ttgagaacct aaagctttca   4200

atcaatcaca agattacaga ggaaggatac agaaatttct ttcaagcact ggacaacatg   4260

ccaaacttgc aggagttgga catctccagg catttcacag agtgtatcaa agctcaggcc   4320

acaacagtca agtctttgag tcaatgtgtg ttacgactac caaggctcat tagactgaac   4380

atgttaagtt ggctcttgga tgcagatgat attgcattgc ttaatgtcat gaaagaaaga   4440

catcctcaat ctaagtactt aactattctc cagaaatgga tactgccgtt ctctccaatc   4500

attcagaaat aaaagattca gctaaaaact gctgaatcaa taatttgtct tggggcatat   4560

tgaggatgta aaaaaagttg ttgattaatg ctaaaaacca aattatccaa aattatttta   4620

ttaaatattg catacaaaag aaaatgtgta aggcttgcta aaaaacaaaa caaaacaaaa   4680

cacagtcctg catactcacc accaagctca agaaataaat catcaccaat acctttgagg   4740

tccctgagta atccacccca gctaaaggca aacccttcaa tcaagtttat acagcaaacc   4800

ctccattgtc catggtcaac agggaagggg ttggggacag gtctgccaat ctatctaaaa   4860

gccacaatat ggaagaagta ttcaatttat ataataaatg gctaacttaa cggttgaatc   4920

actttcatac atggatgaaa cgggtttaac acaggatcca catgaatctt ctgtgggcca   4980

agagatgttc cttaatcctt gtagaacctg ttttctatat tgaactagct ttggtacagt   5040

agagttaact tactttccat ttatccactg ccaatataaa gaggaaacag gggttaggga   5100

aaaatgactt cattccagag gcttctcaga gttcaacata tgctataatt tagaattttc   5160

ttatgaatcc actctacttg ggtagaaaat attttatctc tagtgattgc atattatttc   5220

catatcatag tatttcatag tattatattt gatatgagtg tctatatcaa tgtcagtgtc   5280

cagaatttcg ttcctaccag ttaagtagtt ttctgaacgg ccagaagacc attcgaaatt   5340

catgatacta ctataagttg gtaaacaacc atacttttat cctcattttt attctcacta   5400

agaaaaaagt caactcccct ccccttgccc aagtatgaaa tatagggaca gtatgtatgg   5460

tgtggtctca tttgtttaga aaaccactta tgactgggtg cggtggctca cacctgtaat   5520

cccagcactt tgggaggctg aggcgggcga atcatttgag gtgaggaatt cgagaccagc   5580

ctggccagca tggtgaaacc ccatctctac taaaaataca aaaattagcc aggtgtggtg   5640

gcacatgcct gtagtcccag ccactagggc ggctgagacg caagacttgc ttgaacccgg   5700

gaggcagagg ttgcagtgag ccaagatggc gccactgcat tccagcctgg gcaacagagc   5760

aagaccctgt ctgtctcaaa acaaaaaaca aaaccactta tattgctagc tacattaaga   5820

atttctgaat atgttactga gcttgcttgt ggtaaccatt tataatatca gaaagtatat   5880

gtacaccaaa acatgttgaa catccatgtt gtacaactga aatataaata attttgtcaa   5940

ttatacctaa ataaaactgg aaaaaaattt ctggaagttt atatctaaaa atgttaatag   6000

tgcgtacctc taggaagtgg gcctggaagc cattcttact tttcagtctc tcccattctg   6060

tactgttttt tgttttactt tcgtgcctgc attatttttc tatttaaaac aaaaataaat   6120

ctagtttagc act                                                      6133


<210>  1034
<211>  1403
<212>  PRT
<213>  Homosapiens

<400>  1034

Met Ala Thr Gln Gln Lys Ala Ser Asp Glu Arg Ile Ser Gln Phe Asp 
1               5                   10                  15      


His Asn Leu Leu Pro Glu Leu Ser Ala Leu Leu Gly Leu Asp Ala Val 
            20                  25                  30          


Gln Leu Ala Lys Glu Leu Glu Glu Glu Glu Gln Lys Glu Arg Ala Lys 
        35                  40                  45              


Met Gln Lys Gly Tyr Asn Ser Gln Met Arg Ser Glu Ala Lys Arg Leu 
    50                  55                  60                  


Lys Thr Phe Val Thr Tyr Glu Pro Tyr Ser Ser Trp Ile Pro Gln Glu 
65                  70                  75                  80  


Met Ala Ala Ala Gly Phe Tyr Phe Thr Gly Val Lys Ser Gly Ile Gln 
                85                  90                  95      


Cys Phe Cys Cys Ser Leu Ile Leu Phe Gly Ala Gly Leu Thr Arg Leu 
            100                 105                 110         


Pro Ile Glu Asp His Lys Arg Phe His Pro Asp Cys Gly Phe Leu Leu 
        115                 120                 125             


Asn Lys Asp Val Gly Asn Ile Ala Lys Tyr Asp Ile Arg Val Lys Asn 
    130                 135                 140                 


Leu Lys Ser Arg Leu Arg Gly Gly Lys Met Arg Tyr Gln Glu Glu Glu 
145                 150                 155                 160 


Ala Arg Leu Ala Ser Phe Arg Asn Trp Pro Phe Tyr Val Gln Gly Ile 
                165                 170                 175     


Ser Pro Cys Val Leu Ser Glu Ala Gly Phe Val Phe Thr Gly Lys Gln 
            180                 185                 190         


Asp Thr Val Gln Cys Phe Ser Cys Gly Gly Cys Leu Gly Asn Trp Glu 
        195                 200                 205             


Glu Gly Asp Asp Pro Trp Lys Glu His Ala Lys Trp Phe Pro Lys Cys 
    210                 215                 220                 


Glu Phe Leu Arg Ser Lys Lys Ser Ser Glu Glu Ile Thr Gln Tyr Ile 
225                 230                 235                 240 


Gln Ser Tyr Lys Gly Phe Val Asp Ile Thr Gly Glu His Phe Val Asn 
                245                 250                 255     


Ser Trp Val Gln Arg Glu Leu Pro Met Ala Ser Ala Tyr Cys Asn Asp 
            260                 265                 270         


Ser Ile Phe Ala Tyr Glu Glu Leu Arg Leu Asp Ser Phe Lys Asp Trp 
        275                 280                 285             


Pro Arg Glu Ser Ala Val Gly Val Ala Ala Leu Ala Lys Ala Gly Leu 
    290                 295                 300                 


Phe Tyr Thr Gly Ile Lys Asp Ile Val Gln Cys Phe Ser Cys Gly Gly 
305                 310                 315                 320 


Cys Leu Glu Lys Trp Gln Glu Gly Asp Asp Pro Leu Asp Asp His Thr 
                325                 330                 335     


Arg Cys Phe Pro Asn Cys Pro Phe Leu Gln Asn Met Lys Ser Ser Ala 
            340                 345                 350         


Glu Val Thr Pro Asp Leu Gln Ser Arg Gly Glu Leu Cys Glu Leu Leu 
        355                 360                 365             


Glu Thr Thr Ser Glu Ser Asn Leu Glu Asp Ser Ile Ala Val Gly Pro 
    370                 375                 380                 


Ile Val Pro Glu Met Ala Gln Gly Glu Ala Gln Trp Phe Gln Glu Ala 
385                 390                 395                 400 


Lys Asn Leu Asn Glu Gln Leu Arg Ala Ala Tyr Thr Ser Ala Ser Phe 
                405                 410                 415     


Arg His Met Ser Leu Leu Asp Ile Ser Ser Asp Leu Ala Thr Asp His 
            420                 425                 430         


Leu Leu Gly Cys Asp Leu Ser Ile Ala Ser Lys His Ile Ser Lys Pro 
        435                 440                 445             


Val Gln Glu Pro Leu Val Leu Pro Glu Val Phe Gly Asn Leu Asn Ser 
    450                 455                 460                 


Val Met Cys Val Glu Gly Glu Ala Gly Ser Gly Lys Thr Val Leu Leu 
465                 470                 475                 480 


Lys Lys Ile Ala Phe Leu Trp Ala Ser Gly Cys Cys Pro Leu Leu Asn 
                485                 490                 495     


Arg Phe Gln Leu Val Phe Tyr Leu Ser Leu Ser Ser Thr Arg Pro Asp 
            500                 505                 510         


Glu Gly Leu Ala Ser Ile Ile Cys Asp Gln Leu Leu Glu Lys Glu Gly 
        515                 520                 525             


Ser Val Thr Glu Met Cys Met Arg Asn Ile Ile Gln Gln Leu Lys Asn 
    530                 535                 540                 


Gln Val Leu Phe Leu Leu Asp Asp Tyr Lys Glu Ile Cys Ser Ile Pro 
545                 550                 555                 560 


Gln Val Ile Gly Lys Leu Ile Gln Lys Asn His Leu Ser Arg Thr Cys 
                565                 570                 575     


Leu Leu Ile Ala Val Arg Thr Asn Arg Ala Arg Asp Ile Arg Arg Tyr 
            580                 585                 590         


Leu Glu Thr Ile Leu Glu Ile Lys Ala Phe Pro Phe Tyr Asn Thr Val 
        595                 600                 605             


Cys Ile Leu Arg Lys Leu Phe Ser His Asn Met Thr Arg Leu Arg Lys 
    610                 615                 620                 


Phe Met Val Tyr Phe Gly Lys Asn Gln Ser Leu Gln Lys Ile Gln Lys 
625                 630                 635                 640 


Thr Pro Leu Phe Val Ala Ala Ile Cys Ala His Trp Phe Gln Tyr Pro 
                645                 650                 655     


Phe Asp Pro Ser Phe Asp Asp Val Ala Val Phe Lys Ser Tyr Met Glu 
            660                 665                 670         


Arg Leu Ser Leu Arg Asn Lys Ala Thr Ala Glu Ile Leu Lys Ala Thr 
        675                 680                 685             


Val Ser Ser Cys Gly Glu Leu Ala Leu Lys Gly Phe Phe Ser Cys Cys 
    690                 695                 700                 


Phe Glu Phe Asn Asp Asp Asp Leu Ala Glu Ala Gly Val Asp Glu Asp 
705                 710                 715                 720 


Glu Asp Leu Thr Met Cys Leu Met Ser Lys Phe Thr Ala Gln Arg Leu 
                725                 730                 735     


Arg Pro Phe Tyr Arg Phe Leu Ser Pro Ala Phe Gln Glu Phe Leu Ala 
            740                 745                 750         


Gly Met Arg Leu Ile Glu Leu Leu Asp Ser Asp Arg Gln Glu His Gln 
        755                 760                 765             


Asp Leu Gly Leu Tyr His Leu Lys Gln Ile Asn Ser Pro Met Met Thr 
    770                 775                 780                 


Val Ser Ala Tyr Asn Asn Phe Leu Asn Tyr Val Ser Ser Leu Pro Ser 
785                 790                 795                 800 


Thr Lys Ala Gly Pro Lys Ile Val Ser His Leu Leu His Leu Val Asp 
                805                 810                 815     


Asn Lys Glu Ser Leu Glu Asn Ile Ser Glu Asn Asp Asp Tyr Leu Lys 
            820                 825                 830         


His Gln Pro Glu Ile Ser Leu Gln Met Gln Leu Leu Arg Gly Leu Trp 
        835                 840                 845             


Gln Ile Cys Pro Gln Ala Tyr Phe Ser Met Val Ser Glu His Leu Leu 
    850                 855                 860                 


Val Leu Ala Leu Lys Thr Ala Tyr Gln Ser Asn Thr Val Ala Ala Cys 
865                 870                 875                 880 


Ser Pro Phe Val Leu Gln Phe Leu Gln Gly Arg Thr Leu Thr Leu Gly 
                885                 890                 895     


Ala Leu Asn Leu Gln Tyr Phe Phe Asp His Pro Glu Ser Leu Ser Leu 
            900                 905                 910         


Leu Arg Ser Ile His Phe Pro Ile Arg Gly Asn Lys Thr Ser Pro Arg 
        915                 920                 925             


Ala His Phe Ser Val Leu Glu Thr Cys Phe Asp Lys Ser Gln Val Pro 
    930                 935                 940                 


Thr Ile Asp Gln Asp Tyr Ala Ser Ala Phe Glu Pro Met Asn Glu Trp 
945                 950                 955                 960 


Glu Arg Asn Leu Ala Glu Lys Glu Asp Asn Val Lys Ser Tyr Met Asp 
                965                 970                 975     


Met Gln Arg Arg Ala Ser Pro Asp Leu Ser Thr Gly Tyr Trp Lys Leu 
            980                 985                 990         


Ser Pro Lys Gln Tyr Lys Ile Pro  Cys Leu Glu Val Asp  Val Asn Asp 
        995                 1000                 1005             


Ile Asp  Val Val Gly Gln Asp  Met Leu Glu Ile Leu  Met Thr Val 
    1010                 1015                 1020             


Phe Ser  Ala Ser Gln Arg Ile  Glu Leu His Leu Asn  His Ser Arg 
    1025                 1030                 1035             


Gly Phe  Ile Glu Ser Ile Arg  Pro Ala Leu Glu Leu  Ser Lys Ala 
    1040                 1045                 1050             


Ser Val  Thr Lys Cys Ser Ile  Ser Lys Leu Glu Leu  Ser Ala Ala 
    1055                 1060                 1065             


Glu Gln  Glu Leu Leu Leu Thr  Leu Pro Ser Leu Glu  Ser Leu Glu 
    1070                 1075                 1080             


Val Ser  Gly Thr Ile Gln Ser  Gln Asp Gln Ile Phe  Pro Asn Leu 
    1085                 1090                 1095             


Asp Lys  Phe Leu Cys Leu Lys  Glu Leu Ser Val Asp  Leu Glu Gly 
    1100                 1105                 1110             


Asn Ile  Asn Val Phe Ser Val  Ile Pro Glu Glu Phe  Pro Asn Phe 
    1115                 1120                 1125             


His His  Met Glu Lys Leu Leu  Ile Gln Ile Ser Ala  Glu Tyr Asp 
    1130                 1135                 1140             


Pro Ser  Lys Leu Val Lys Leu  Ile Gln Asn Ser Pro  Asn Leu His 
    1145                 1150                 1155             


Val Phe  His Leu Lys Cys Asn  Phe Phe Ser Asp Phe  Gly Ser Leu 
    1160                 1165                 1170             


Met Thr  Met Leu Val Ser Cys  Lys Lys Leu Thr Glu  Ile Lys Phe 
    1175                 1180                 1185             


Ser Asp  Ser Phe Phe Gln Ala  Val Pro Phe Val Ala  Ser Leu Pro 
    1190                 1195                 1200             


Asn Phe  Ile Ser Leu Lys Ile  Leu Asn Leu Glu Gly  Gln Gln Phe 
    1205                 1210                 1215             


Pro Asp  Glu Glu Thr Ser Glu  Lys Phe Ala Tyr Ile  Leu Gly Ser 
    1220                 1225                 1230             


Leu Ser  Asn Leu Glu Glu Leu  Ile Leu Pro Thr Gly  Asp Gly Ile 
    1235                 1240                 1245             


Tyr Arg  Val Ala Lys Leu Ile  Ile Gln Gln Cys Gln  Gln Leu His 
    1250                 1255                 1260             


Cys Leu  Arg Val Leu Ser Phe  Phe Lys Thr Leu Asn  Asp Asp Ser 
    1265                 1270                 1275             


Val Val  Glu Ile Ala Lys Val  Ala Ile Ser Gly Gly  Phe Gln Lys 
    1280                 1285                 1290             


Leu Glu  Asn Leu Lys Leu Ser  Ile Asn His Lys Ile  Thr Glu Glu 
    1295                 1300                 1305             


Gly Tyr  Arg Asn Phe Phe Gln  Ala Leu Asp Asn Met  Pro Asn Leu 
    1310                 1315                 1320             


Gln Glu  Leu Asp Ile Ser Arg  His Phe Thr Glu Cys  Ile Lys Ala 
    1325                 1330                 1335             


Gln Ala  Thr Thr Val Lys Ser  Leu Ser Gln Cys Val  Leu Arg Leu 
    1340                 1345                 1350             


Pro Arg  Leu Ile Arg Leu Asn  Met Leu Ser Trp Leu  Leu Asp Ala 
    1355                 1360                 1365             


Asp Asp  Ile Ala Leu Leu Asn  Val Met Lys Glu Arg  His Pro Gln 
    1370                 1375                 1380             


Ser Lys  Tyr Leu Thr Ile Leu  Gln Lys Trp Ile Leu  Pro Phe Ser 
    1385                 1390                 1395             


Pro Ile  Ile Gln Lys 
    1400             


<210>  1035
<211>  1936
<212>  DNA
<213>  Homosapiens

<400>  1035
ggtgagtccg cgtgtggaag tctgtgaggc gcagaggtgg ggcaggccgt ctggctagct     60

aggcggctgg gagcgttttc gtggcgggga acggaggttg aattgccctg cctgggctca    120

tagggaagga ggatgtgaag gagcttgtga aggcagagga agattattga ataataaaat    180

acagttttga aaaaaatgga tgaagaacct gaaagaacta agcgatggga aggaggctat    240

gaaagaacat gggagattct taaagaagat gaatctggat cacttaaagc tacaatagaa    300

gacattctat tcaaggcaaa gagaaaaaga gtatttgagc accatggaca agttcgactt    360

ggaatgatgc gccaccttta tgtggtagta gatggatcaa gaacaatgga agaccaagat    420

ttaaagccta atagactgac gtgtacttta aagttgttgg aatactttgt agaggaatat    480

tttgatcaaa atcctattag tcagattgga ataattgtaa ctaagagtaa aagagctgaa    540

aaattgactg aactttcagg aaacccaaga aaacatataa cgtctttgaa gaaagctgtg    600

gatatgacct gccatggaga gccatctctt tataattccc taagcatagc tatgcagact    660

ctaaaacaca tgcctggaca tacaagtcga gaagtactaa tcatctttag cagccttaca    720

acttgcgatc catctaatat ttatgatcta atcaagaccc taaaggcagc taaaattaga    780

gtatctgtta ttggattgtc tgcagaagtt cgcgtttgca ctgtacttgc tcgtgaaact    840

ggtggcacgt accatgttat tttagatgaa agccattaca aagagttgct cacacatcat    900

gttagtcctc ctcctgctag ctcaagttct gaatgctcac ttattcgtat gggatttcct    960

cagcacacca ttgcttcttt atctgaccag gatgcaaaac cctctttcag catggcgcat   1020

ttggatggca atactgagcc agggcttaca ttaggaggct atttctgccc acagtgtcgg   1080

gcaaagtact gtgagctacc tgttgaatgt aaaatctgtg gtcttacttt ggtgtctgct   1140

ccccacttgg cacggtctta ccatcatttg tttcctttgg atgcttttca agaaattccc   1200

ctagaagaat ataatggaga aagattttgt tatggatgtc agggggaatt gaaagaccaa   1260

catgtttatg tttgtgctgt gtgccaaaat gttttctgtg tggactgtga tgtttttgtt   1320

catgattctc tacactgttg ccctggctgt attcataaga ttccagctcc ttcaggtgtt   1380

tgattccagc atgtagtata cattgtatgt gttaaaaaga aatttgcaac tgtgaataaa   1440

aggacttctt tagaagaagc ttcatttaaa acatgaaagg ataatctgac ttaagaaact   1500

ttttgctaag aaaaggtaat attttattaa attttaaatt tgtgttgtca cagaaatacc   1560

tgaaattcag tagtacttca ttcaattaat tttgttttct attattttga gttatactgt   1620

tttcaaagtc attatgcagt atgtataaac ttataagaat taaattgatg tgataatttt   1680

atgtttttat aattaaatat agaatcttta tgatttatgt taattcatta atttagtgta   1740

agaagaaagt taagtctgaa tgtaaattca gtgtaagatg aaaatttatc aatacttatg   1800

aaattaggct gggcgctgtg gctcacacct gtaatcccaa cactttggga ggctgaggtg   1860

ggcagatcac ttgaggtcag gagttcgaga ccagcctggc caacatggtg aaaccccgtc   1920

actactaaaa atacaa                                                   1936


<210>  1036
<211>  395
<212>  PRT
<213>  Homosapiens

<400>  1036

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Lys Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Ile Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Ile Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Val Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
            340                 345                 350         


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
        355                 360                 365             


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
    370                 375                 380                 


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
385                 390                 395 


<210>  1037
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1037
agttgcggcg tcctgtgagc gcggggatgc tgggaggagg gtgaaattta gccatcggtg     60

tgtggcaggg tcatgaaaaa gcggcggcgg cgggagagag gaggaggcgg cggcggggca    120

gtgaaactac ggtagctgcc ccctgagctg gtggtgtggc tttgtgggga gggcgtagtt    180

cctaatcccc tttccgggca gccgccgggg ctcggggctg tgagcggccg tgaggctgcc    240

tccccgggcc ccctgcctcc gccatgttcc gcagggcacg ccttagcgtg aagccgaatg    300

tcaggcctgg tgtaggcgcc aggggctcca cagcttccaa tccccagcgt ggacgggagt    360

ctcccaggcc gccggatcct gccacggact ctgcttccaa gcccgcggag cccacagatg    420

tgcccacagt cgatttcggt ggagcggagc cccaagaaaa ggctcctagg agcagtactg    480

aaaagactgg tggtgacaat gatgttgaag aatccagtag atcttcctct actgtttcac    540

agagaagaaa gcgaatatca agtacttcta gcctggttaa gtctagtgtc agtgttcctt    600

cagaatctca tcccttatct acaattaatc aagaggctcc acagccaact gccacttcaa    660

caaaagagaa acagccatgc tcagacagat accgaatata caaagcccag aaactgaggg    720

aaatgttaaa agaagaattg agaaaagaga agaaacaatg gaaaaacaaa tatgctataa    780

atgaaagtca gaggccacca gatcgttcaa aaatgactat gagagacttc atatattatc    840

taccagataa taatccaatg acttcttcac tggaacaaga aaagaaaact gaaaagccat    900

cgactccagt ccagacaaga gagcaagaag gtaagagtac tcctaatgct gaagataatg    960

aaatggaaga agagacagat gatgggccat tactggttcc tcgagtaaaa gtggcagaag   1020

atggttccat tattttggat gaagaaagtt taactgtaga agttttaaga acaaaaggcc   1080

cttgtgttgt tgaagaaaat gaccccatat ttgagcgcgg ttctacaact acatactcca   1140

gctttaggaa aaactattac tctaaaccat ggtcaaataa agaaacagat atgttttttt   1200

tagccatcag catggtagga actgactttt ctatgatcgg acaacttttt cctcacagag   1260

caaggataga aattaagaat aaatttaaac gggaagagaa aacaaatgga tggagaatag   1320

acaaagcatt ccaggaaaag cgcccttttg acttcgattt ttttgctcat ttgcttcaga   1380

aagttcttgc tgaagaagag aaaagaaaac aaaaatctgt taaaaatcac agtttaaagg   1440

agaagaaatc caccaaacca cggaaaaatg taaaagtgaa aaaagttgcc tgtgaaggag   1500

tgaataatga tccagatgag tctatgagtt ctagaatttc agacacggaa agatctcaga   1560

aggatgctca gacagttgaa gaagagtctc tgaccttatc aagggaggat gcagagcagg   1620

ttgcattaga agtagaccta aatcaaaaga aaagaaggag gaagaagcaa gatggagcta   1680

atgaactggg agtaaacaat cttttagaaa atgccactgt tcaggcgggt ccttctaaag   1740

gagaaaaaca caagaataaa tgtcaggcta taaggcctga gctaaaggaa ggtgaatgca   1800

gtaaggagca gatgctttcc tgcacacaaa acatagatgg cattgtgggt tttgcctcca   1860

ctgaaaaagt tgagaaaaga actgacccca tcctttcatt aagtaatcaa caagatgcca   1920

catcagtagc aactgagtct tcagaatcaa gcacttcaga tttgccttca ttcgaagttg   1980

gaattagagc attgtgtgag gtgaataatg ctgagggtag ttgtatagaa gaaagaaatg   2040

ttgacctaaa aaataattca ctggaaattg atcaaacaga aaatgttaaa ccaatgttga   2100

gaggtcgctt ccaaagacct aaacccaatt tgtcaagggc tgggaagaaa tcagttcttt   2160

cacaaggcaa aacagagtca gagagcaaga attcacattc aaaaacttca gttgaaaaga   2220

accacgtgga aaaagataaa atgaatacat tggacatttt gagaatggag actacagaga   2280

gagagaatcc agaagctgaa actgtatctg ttttgggtga aaaaaattgt ctgcaggaag   2340

ggagtcaact aaaggcttta agacctgtac aagtgagggg ccgattgcaa aagccaaagc   2400

caaatgcagg taaagctgct gaaagaaaag aaattctcat atcacaggaa gaaattgggg   2460

ccaatgtaga gaagaatgaa aatgaatcct gtgctgatag agatactcct caacacatgg   2520

aagatcaatc gcgtaaagat tttgaagagg aagatgtcat attacagcct gagaaaaatg   2580

attcttttca aaatgtgcag ccagatgagc ccaaggttct taatgaatgt ctaagcgttc   2640

aagagaataa taaggcaaat aaacttaacc aagtcccaat tctaaggact cgatttcaga   2700

aaccaaagcc aaatatagga agaggaactg gaaggagaga aatttcctca aaggaagagg   2760

tactagagaa gattcttgtc tctggggaaa tggcggcagc attgagagaa actgtaagac   2820

tagacacctc accaaaggag atggtaccag cagagattaa tactaaagaa atgcagtcag   2880

atttaaaaga aactggaaga agagccattt ctcccaggga gaagattcta gatgtgattg   2940

atgacaccat agaaatggag acaggtctga aagcaatggg aagagagatt tgtctaaggg   3000

agaagacgcc agaggtgatt gatgccactg aggaaataga caaagatttg gaagaagctg   3060

gaagaagaga aatatcccca cagaaaaatg gcccagagga ggttaagcct ctaggtgaag   3120

tggagacaga tttgaaagca actggaaatg agagttcccc aagggagaag acaccagagg   3180

tgactgatgc cactgaggaa atagacaaaa atttggaaga aactggaaga agaaaaatat   3240

ccccaaggga aaatggccca gaggaggtca agcctgtaga tgaaatggag acagatttga   3300

acgcaactgg aagagagagt tctccaaggg agaagacacc agaggtgatt gatgctactg   3360

aggaaataga tttggaagaa actgaaagag aagtatcccc acaggaaaat ggactagagg   3420

aggtcaagcc tctaggtgaa atggagacgg atttgaaagc aactggaaga gacagtttcc   3480

caagggggaa gacaccagag gtgattgatg ccattgagga aatagagata gatttggaag   3540

aaactgaaag agaaatatcc ccacaggaaa atggcctaga ggaggttaag cctctaggtg   3600

aaatgcaaac agatttgaaa gcaaccggaa gggagatttc cccaagggag aagacaccag   3660

aggtgattga tgccactgag gaaatagaca aagatctgga agaaactgga agaagagaaa   3720

tatccccaga ggaaaatggc ccagaggagg tcaagcctgt agatgaaatg gagacagact   3780

tgaaaacaac tggaagagag ggttcctcaa gggagaagac acgagaggtg attgatgctg   3840

ctgaggtaat agagacagat ttggaagaaa ctgaaagaga aatatcgcca caggaaaatg   3900

gcccagagga ggtcaagcct gtaggtaaaa tggagacaga tttgaaagaa attagagaag   3960

aaatttccca aagggaaaag gtgctagcag agttcagtgc tataagggaa aaggagattg   4020

atttgaaaga aactggaaaa agagacattc ccatcatgga gaaagtatca ggaaagatgg   4080

ctgttgttga agaaatggag gcagatttga aagaaactgg aaaagaaaat tttagagaga   4140

gaggatctga agagatctgt gttactgagg aaaaggtggc agaattgaaa caaactggaa   4200

aaacagacat ttctccaagg gaaaacgagc tagaggagac cagtacctca agacaaactg   4260

acacacattt aatgcagagc ggtagcaatg acttcagtgc tgtgccttca ctagatattc   4320

agaacattag cagtgaagta ctgtcgatga tgcatacacc tgtagaagaa aaaagaaatt   4380

ctgaaaaaga agtatcaagt cacttcagtc atttcaagat ttcttcacag actcatgaat   4440

ctgataaaac agaagtccag gggattcaat ctccagatgt tccagagcag ttttcagata   4500

ttaatttaag caaatctctt cctcaagaac agaagccact tgaaattaaa ccagcacctt   4560

ttgtgaggag ccgattcaaa agaccaaaac caaacttagc aagagcagct ttgaagagag   4620

agactacaga atcagaaaaa tatatatatg agaagaaatc agaaaccaag aaaatggaga   4680

ctattgtgat gcaagaaaat aatgaacaaa ctgatactct cccttctcaa catgatgaag   4740

cttccctaat gatatcaaga gaaaaagaca cattaggtca caggaatgag gaggctgtga   4800

tattgccatg tacacagact gaaaggaacc tttcaccttc aaattcttgt gaacctaaag   4860

aggagtctca gtcagcacca gtccagaaaa atgactcagt tgtttctgtg gggactaata   4920

atgtaaacac tttccagcaa gaaatgaagg aaagtgttat ccaaactgct cgacaagtaa   4980

ggggccgact tcagagaccg agaccaaata taagaaagac aggacagagg caaatagtag   5040

acaaaggtga agccaaaggc ataattaagg aaggaagaac gatattacca aaagatgaaa   5100

ctgaaaagaa agtcttaact gtgtcaaatt ctcaaattga aactgaaatt gaagttccat   5160

cgtccgcagt tccagaacac agaatgtatg aaaatcaaag tcaggtggtt cttgtagaaa   5220

accttcatgt taacaaaaca aatgaaacaa tcagacatga aaataaaccg tatgttccta   5280

gttcagcaca aatgacaaga aggaaattcc aaaaggctaa gccaaatttg ggaagagcac   5340

acagtaagaa agaggaacca gttttagaaa aagtcacaac agatcagagc aaggaaggca   5400

agccagaaga tcatttgctg cagaaaggag cttccaacac ccagctcctt ctaaaagaaa   5460

aagctgagct tctgacatct ctggaggttt cagcaagaaa agattgtgta ggttccaaag   5520

agtctgcttt ggcaaaaata gatgcggaat tagaagaagt tggaccatca agaagggttg   5580

gagaggaaac tgtaggagat aattcaccat cttcagttgt tgaagagcaa tatctcaata   5640

aactaacaag ctgtccacaa ccgttaaacg aaacaagtta ctctaaaatt gccctggatg   5700

ggaaaacaac tatctcttct acatctgagt atgagagaaa tcgtggtgaa aggagaagtc   5760

ataaaaagtt caaaccaaat gtcaccagag gtcgtggatc aaaacgagtt cggggtaaga   5820

cctctaagaa ggaacctaga gcttccaagg ccatgctggt gactcttcgg gcttcccagg   5880

aagaagatga tgatgctgac gattttgagt ctgactatga ggaagaaagc tatcatcttg   5940

ctcccgaaga agtaaacaaa gctccagtat ttgtacctgt tggtctcaga tctcctgaac   6000

ctgtttctgc tcagattgag gaaacaatgg aagagcttga aataactgtg aatgtcccag   6060

atgtaggatg catagctgtt gttgaacatg agctaccaaa cacagatgtg actactgaag   6120

aaatgaaaca agaagaaaat ttgagtgtac cgtttgaaat gaccacaagt gaacatatcc   6180

aagatgaacc aggtaccaat gatggaagca ccgaagctgc aataacttta cttacaatgg   6240

gagatctagt attgcagtca gagatcagta gtgaacaggg tgatgtagga gtatgtataa   6300

ttcctcatgt tcattcaaag gataaaagcc atattccttc tagcctagat aatgtaaatc   6360

acaaaattgt tcatgaatgt caggaacttt cttcacctgt cattactaca tctcctgcat   6420

catttgaaga aaacaagatt gtattggagg aacaaagttc cagagaagaa ataagtttaa   6480

tggagaaagt aaaggagaat gctacaccaa ccaggaatac aatttctaaa gtgaccagta   6540

atttgagaat aagaagtagg cttgctaagc ctaaaccaaa tcttgagaag actttaggga   6600

ccaacaggct tgatgattat caggaagttt ccagtttgtg tgtaaccaaa ggggcagaaa   6660

tggaaactca aagagaaaca gagaaaaatg cttccaaagc aacagaattg gaaaataaaa   6720

acctcggacc agttacaaca gcagagaata aggatcagag caaattggca tgtgtacatg   6780

gtatcaaagg gaccagtatt tcttcagaag taaacctaac tgaaagaaac gaaaatcaag   6840

aagagagctc tcaggaggtt cacatgttgt cagttgctcc agttgcttcc tctgagacag   6900

ggccctgcac acttggtttg gataggggtc ttggtgaaaa ttctgttgaa gagccccaga   6960

taaaggactc taaaggagac agtgtgctta cacttcctgt gccagagtat acaccaacaa   7020

gtattccaga agtccaacaa gagaatataa tcaatcctca agacctaaca gtgaatctag   7080

ttgctaatgt acctcaagat ggagaagatg aacaagcctt tattttaact ctggtggaaa   7140

tcccagccaa tgcagtagaa gaatttactg atgccactgc acagttcatg ccaaaccctt   7200

tactgccagc tcccatattg gtcaaatcag tgaataccga agaaaggggt gacatgagta   7260

tttgtttacc agcaacttca gttggtcaag atgccatggg tttatctatt tctggaagag   7320

ataattctaa aaagccgcct gataatttgg atcttgtatc taggaagaga tttcaatgca   7380

ggcttgataa aaatgaccac attcctcctg ccaaaaaacg ttcactcact ttaagagatg   7440

actgtcaaga atataccact gaggtgcact caaaggaatt aacaaatgtt tttgaggaaa   7500

caggggagtc tcacaaggga caagatattt ttcttacctc aggaagcaca ctgacaactc   7560

cagaacctca aagacagcaa gttgaagcag cttttcagag tagaggatct agatctcctg   7620

atgcatgcat ggacaagaat gtgcctcagt tacctcagga tgaaatgatt gtgtctgata   7680

aggaagaaag aactgatgct gctcctaagt ctcagcaaat ggatagcaga acatcgtctt   7740

ctaaagcctc actatccaga cctggcagaa gacccctggg atttttatct ttaatatgct   7800

caaagaatag tttggagtct gatgaaccta tgcaagtcca tagtaagaaa cgcctaaaac   7860

ctcttatacc tggattaaga aagaaattga aaagatctaa tccattcaat gaaagccagg   7920

aaaaaaatcg agagtcctct gatctgcttc catctccaag tgttattact actcaatctg   7980

agaatattag cagctcagca actcaggttt cttgtgatca gcccttactg aaagaaggat   8040

ataaaagtgc ccaaaagcgg gcccctcaag gggaggcaac cacagtctct gaatatttct   8100

tcaatgatat cttcattgaa gtggatgaaa cagaataaaa caatcttttc tctttttctt   8160

ttttaaatta ggtctaggat ttccagagtc aa                                 8192


<210>  1038
<211>  2624
<212>  PRT
<213>  Homosapiens

<400>  1038

Met Phe Arg Arg Ala Arg Leu Ser Val Lys Pro Asn Val Arg Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Gly Ser Thr Ala Ser Asn Pro Gln Arg Gly Arg Glu 
            20                  25                  30          


Ser Pro Arg Pro Pro Asp Pro Ala Thr Asp Ser Ala Ser Lys Pro Ala 
        35                  40                  45              


Glu Pro Thr Asp Val Pro Thr Val Asp Phe Gly Gly Ala Glu Pro Gln 
    50                  55                  60                  


Glu Lys Ala Pro Arg Ser Ser Thr Glu Lys Thr Gly Gly Asp Asn Asp 
65                  70                  75                  80  


Val Glu Glu Ser Ser Arg Ser Ser Ser Thr Val Ser Gln Arg Arg Lys 
                85                  90                  95      


Arg Ile Ser Ser Thr Ser Ser Leu Val Lys Ser Ser Val Ser Val Pro 
            100                 105                 110         


Ser Glu Ser His Pro Leu Ser Thr Ile Asn Gln Glu Ala Pro Gln Pro 
        115                 120                 125             


Thr Ala Thr Ser Thr Lys Glu Lys Gln Pro Cys Ser Asp Arg Tyr Arg 
    130                 135                 140                 


Ile Tyr Lys Ala Gln Lys Leu Arg Glu Met Leu Lys Glu Glu Leu Arg 
145                 150                 155                 160 


Lys Glu Lys Lys Gln Trp Lys Asn Lys Tyr Ala Ile Asn Glu Ser Gln 
                165                 170                 175     


Arg Pro Pro Asp Arg Ser Lys Met Thr Met Arg Asp Phe Ile Tyr Tyr 
            180                 185                 190         


Leu Pro Asp Asn Asn Pro Met Thr Ser Ser Leu Glu Gln Glu Lys Lys 
        195                 200                 205             


Thr Glu Lys Pro Ser Thr Pro Val Gln Thr Arg Glu Gln Glu Gly Lys 
    210                 215                 220                 


Ser Thr Pro Asn Ala Glu Asp Asn Glu Met Glu Glu Glu Thr Asp Asp 
225                 230                 235                 240 


Gly Pro Leu Leu Val Pro Arg Val Lys Val Ala Glu Asp Gly Ser Ile 
                245                 250                 255     


Ile Leu Asp Glu Glu Ser Leu Thr Val Glu Val Leu Arg Thr Lys Gly 
            260                 265                 270         


Pro Cys Val Val Glu Glu Asn Asp Pro Ile Phe Glu Arg Gly Ser Thr 
        275                 280                 285             


Thr Thr Tyr Ser Ser Phe Arg Lys Asn Tyr Tyr Ser Lys Pro Trp Ser 
    290                 295                 300                 


Asn Lys Glu Thr Asp Met Phe Phe Leu Ala Ile Ser Met Val Gly Thr 
305                 310                 315                 320 


Asp Phe Ser Met Ile Gly Gln Leu Phe Pro His Arg Ala Arg Ile Glu 
                325                 330                 335     


Ile Lys Asn Lys Phe Lys Arg Glu Glu Lys Thr Asn Gly Trp Arg Ile 
            340                 345                 350         


Asp Lys Ala Phe Gln Glu Lys Arg Pro Phe Asp Phe Asp Phe Phe Ala 
        355                 360                 365             


His Leu Leu Gln Lys Val Leu Ala Glu Glu Glu Lys Arg Lys Gln Lys 
    370                 375                 380                 


Ser Val Lys Asn His Ser Leu Lys Glu Lys Lys Ser Thr Lys Pro Arg 
385                 390                 395                 400 


Lys Asn Val Lys Val Lys Lys Val Ala Cys Glu Gly Val Asn Asn Asp 
                405                 410                 415     


Pro Asp Glu Ser Met Ser Ser Arg Ile Ser Asp Thr Glu Arg Ser Gln 
            420                 425                 430         


Lys Asp Ala Gln Thr Val Glu Glu Glu Ser Leu Thr Leu Ser Arg Glu 
        435                 440                 445             


Asp Ala Glu Gln Val Ala Leu Glu Val Asp Leu Asn Gln Lys Lys Arg 
    450                 455                 460                 


Arg Arg Lys Lys Gln Asp Gly Ala Asn Glu Leu Gly Val Asn Asn Leu 
465                 470                 475                 480 


Leu Glu Asn Ala Thr Val Gln Ala Gly Pro Ser Lys Gly Glu Lys His 
                485                 490                 495     


Lys Asn Lys Cys Gln Ala Ile Arg Pro Glu Leu Lys Glu Gly Glu Cys 
            500                 505                 510         


Ser Lys Glu Gln Met Leu Ser Cys Thr Gln Asn Ile Asp Gly Ile Val 
        515                 520                 525             


Gly Phe Ala Ser Thr Glu Lys Val Glu Lys Arg Thr Asp Pro Ile Leu 
    530                 535                 540                 


Ser Leu Ser Asn Gln Gln Asp Ala Thr Ser Val Ala Thr Glu Ser Ser 
545                 550                 555                 560 


Glu Ser Ser Thr Ser Asp Leu Pro Ser Phe Glu Val Gly Ile Arg Ala 
                565                 570                 575     


Leu Cys Glu Val Asn Asn Ala Glu Gly Ser Cys Ile Glu Glu Arg Asn 
            580                 585                 590         


Val Asp Leu Lys Asn Asn Ser Leu Glu Ile Asp Gln Thr Glu Asn Val 
        595                 600                 605             


Lys Pro Met Leu Arg Gly Arg Phe Gln Arg Pro Lys Pro Asn Leu Ser 
    610                 615                 620                 


Arg Ala Gly Lys Lys Ser Val Leu Ser Gln Gly Lys Thr Glu Ser Glu 
625                 630                 635                 640 


Ser Lys Asn Ser His Ser Lys Thr Ser Val Glu Lys Asn His Val Glu 
                645                 650                 655     


Lys Asp Lys Met Asn Thr Leu Asp Ile Leu Arg Met Glu Thr Thr Glu 
            660                 665                 670         


Arg Glu Asn Pro Glu Ala Glu Thr Val Ser Val Leu Gly Glu Lys Asn 
        675                 680                 685             


Cys Leu Gln Glu Gly Ser Gln Leu Lys Ala Leu Arg Pro Val Gln Val 
    690                 695                 700                 


Arg Gly Arg Leu Gln Lys Pro Lys Pro Asn Ala Gly Lys Ala Ala Glu 
705                 710                 715                 720 


Arg Lys Glu Ile Leu Ile Ser Gln Glu Glu Ile Gly Ala Asn Val Glu 
                725                 730                 735     


Lys Asn Glu Asn Glu Ser Cys Ala Asp Arg Asp Thr Pro Gln His Met 
            740                 745                 750         


Glu Asp Gln Ser Arg Lys Asp Phe Glu Glu Glu Asp Val Ile Leu Gln 
        755                 760                 765             


Pro Glu Lys Asn Asp Ser Phe Gln Asn Val Gln Pro Asp Glu Pro Lys 
    770                 775                 780                 


Val Leu Asn Glu Cys Leu Ser Val Gln Glu Asn Asn Lys Ala Asn Lys 
785                 790                 795                 800 


Leu Asn Gln Val Pro Ile Leu Arg Thr Arg Phe Gln Lys Pro Lys Pro 
                805                 810                 815     


Asn Ile Gly Arg Gly Thr Gly Arg Arg Glu Ile Ser Ser Lys Glu Glu 
            820                 825                 830         


Val Leu Glu Lys Ile Leu Val Ser Gly Glu Met Ala Ala Ala Leu Arg 
        835                 840                 845             


Glu Thr Val Arg Leu Asp Thr Ser Pro Lys Glu Met Val Pro Ala Glu 
    850                 855                 860                 


Ile Asn Thr Lys Glu Met Gln Ser Asp Leu Lys Glu Thr Gly Arg Arg 
865                 870                 875                 880 


Ala Ile Ser Pro Arg Glu Lys Ile Leu Asp Val Ile Asp Asp Thr Ile 
                885                 890                 895     


Glu Met Glu Thr Gly Leu Lys Ala Met Gly Arg Glu Ile Cys Leu Arg 
            900                 905                 910         


Glu Lys Thr Pro Glu Val Ile Asp Ala Thr Glu Glu Ile Asp Lys Asp 
        915                 920                 925             


Leu Glu Glu Ala Gly Arg Arg Glu Ile Ser Pro Gln Lys Asn Gly Pro 
    930                 935                 940                 


Glu Glu Val Lys Pro Leu Gly Glu Val Glu Thr Asp Leu Lys Ala Thr 
945                 950                 955                 960 


Gly Asn Glu Ser Ser Pro Arg Glu Lys Thr Pro Glu Val Thr Asp Ala 
                965                 970                 975     


Thr Glu Glu Ile Asp Lys Asn Leu Glu Glu Thr Gly Arg Arg Lys Ile 
            980                 985                 990         


Ser Pro Arg Glu Asn Gly Pro Glu  Glu Val Lys Pro Val  Asp Glu Met 
        995                 1000                 1005             


Glu Thr  Asp Leu Asn Ala Thr  Gly Arg Glu Ser Ser  Pro Arg Glu 
    1010                 1015                 1020             


Lys Thr  Pro Glu Val Ile Asp  Ala Thr Glu Glu Ile  Asp Leu Glu 
    1025                 1030                 1035             


Glu Thr  Glu Arg Glu Val Ser  Pro Gln Glu Asn Gly  Leu Glu Glu 
    1040                 1045                 1050             


Val Lys  Pro Leu Gly Glu Met  Glu Thr Asp Leu Lys  Ala Thr Gly 
    1055                 1060                 1065             


Arg Asp  Ser Phe Pro Arg Gly  Lys Thr Pro Glu Val  Ile Asp Ala 
    1070                 1075                 1080             


Ile Glu  Glu Ile Glu Ile Asp  Leu Glu Glu Thr Glu  Arg Glu Ile 
    1085                 1090                 1095             


Ser Pro  Gln Glu Asn Gly Leu  Glu Glu Val Lys Pro  Leu Gly Glu 
    1100                 1105                 1110             


Met Gln  Thr Asp Leu Lys Ala  Thr Gly Arg Glu Ile  Ser Pro Arg 
    1115                 1120                 1125             


Glu Lys  Thr Pro Glu Val Ile  Asp Ala Thr Glu Glu  Ile Asp Lys 
    1130                 1135                 1140             


Asp Leu  Glu Glu Thr Gly Arg  Arg Glu Ile Ser Pro  Glu Glu Asn 
    1145                 1150                 1155             


Gly Pro  Glu Glu Val Lys Pro  Val Asp Glu Met Glu  Thr Asp Leu 
    1160                 1165                 1170             


Lys Thr  Thr Gly Arg Glu Gly  Ser Ser Arg Glu Lys  Thr Arg Glu 
    1175                 1180                 1185             


Val Ile  Asp Ala Ala Glu Val  Ile Glu Thr Asp Leu  Glu Glu Thr 
    1190                 1195                 1200             


Glu Arg  Glu Ile Ser Pro Gln  Glu Asn Gly Pro Glu  Glu Val Lys 
    1205                 1210                 1215             


Pro Val  Gly Lys Met Glu Thr  Asp Leu Lys Glu Ile  Arg Glu Glu 
    1220                 1225                 1230             


Ile Ser  Gln Arg Glu Lys Val  Leu Ala Glu Phe Ser  Ala Ile Arg 
    1235                 1240                 1245             


Glu Lys  Glu Ile Asp Leu Lys  Glu Thr Gly Lys Arg  Asp Ile Pro 
    1250                 1255                 1260             


Ile Met  Glu Lys Val Ser Gly  Lys Met Ala Val Val  Glu Glu Met 
    1265                 1270                 1275             


Glu Ala  Asp Leu Lys Glu Thr  Gly Lys Glu Asn Phe  Arg Glu Arg 
    1280                 1285                 1290             


Gly Ser  Glu Glu Ile Cys Val  Thr Glu Glu Lys Val  Ala Glu Leu 
    1295                 1300                 1305             


Lys Gln  Thr Gly Lys Thr Asp  Ile Ser Pro Arg Glu  Asn Glu Leu 
    1310                 1315                 1320             


Glu Glu  Thr Ser Thr Ser Arg  Gln Thr Asp Thr His  Leu Met Gln 
    1325                 1330                 1335             


Ser Gly  Ser Asn Asp Phe Ser  Ala Val Pro Ser Leu  Asp Ile Gln 
    1340                 1345                 1350             


Asn Ile  Ser Ser Glu Val Leu  Ser Met Met His Thr  Pro Val Glu 
    1355                 1360                 1365             


Glu Lys  Arg Asn Ser Glu Lys  Glu Val Ser Ser His  Phe Ser His 
    1370                 1375                 1380             


Phe Lys  Ile Ser Ser Gln Thr  His Glu Ser Asp Lys  Thr Glu Val 
    1385                 1390                 1395             


Gln Gly  Ile Gln Ser Pro Asp  Val Pro Glu Gln Phe  Ser Asp Ile 
    1400                 1405                 1410             


Asn Leu  Ser Lys Ser Leu Pro  Gln Glu Gln Lys Pro  Leu Glu Ile 
    1415                 1420                 1425             


Lys Pro  Ala Pro Phe Val Arg  Ser Arg Phe Lys Arg  Pro Lys Pro 
    1430                 1435                 1440             


Asn Leu  Ala Arg Ala Ala Leu  Lys Arg Glu Thr Thr  Glu Ser Glu 
    1445                 1450                 1455             


Lys Tyr  Ile Tyr Glu Lys Lys  Ser Glu Thr Lys Lys  Met Glu Thr 
    1460                 1465                 1470             


Ile Val  Met Gln Glu Asn Asn  Glu Gln Thr Asp Thr  Leu Pro Ser 
    1475                 1480                 1485             


Gln His  Asp Glu Ala Ser Leu  Met Ile Ser Arg Glu  Lys Asp Thr 
    1490                 1495                 1500             


Leu Gly  His Arg Asn Glu Glu  Ala Val Ile Leu Pro  Cys Thr Gln 
    1505                 1510                 1515             


Thr Glu  Arg Asn Leu Ser Pro  Ser Asn Ser Cys Glu  Pro Lys Glu 
    1520                 1525                 1530             


Glu Ser  Gln Ser Ala Pro Val  Gln Lys Asn Asp Ser  Val Val Ser 
    1535                 1540                 1545             


Val Gly  Thr Asn Asn Val Asn  Thr Phe Gln Gln Glu  Met Lys Glu 
    1550                 1555                 1560             


Ser Val  Ile Gln Thr Ala Arg  Gln Val Arg Gly Arg  Leu Gln Arg 
    1565                 1570                 1575             


Pro Arg  Pro Asn Ile Arg Lys  Thr Gly Gln Arg Gln  Ile Val Asp 
    1580                 1585                 1590             


Lys Gly  Glu Ala Lys Gly Ile  Ile Lys Glu Gly Arg  Thr Ile Leu 
    1595                 1600                 1605             


Pro Lys  Asp Glu Thr Glu Lys  Lys Val Leu Thr Val  Ser Asn Ser 
    1610                 1615                 1620             


Gln Ile  Glu Thr Glu Ile Glu  Val Pro Ser Ser Ala  Val Pro Glu 
    1625                 1630                 1635             


His Arg  Met Tyr Glu Asn Gln  Ser Gln Val Val Leu  Val Glu Asn 
    1640                 1645                 1650             


Leu His  Val Asn Lys Thr Asn  Glu Thr Ile Arg His  Glu Asn Lys 
    1655                 1660                 1665             


Pro Tyr  Val Pro Ser Ser Ala  Gln Met Thr Arg Arg  Lys Phe Gln 
    1670                 1675                 1680             


Lys Ala  Lys Pro Asn Leu Gly  Arg Ala His Ser Lys  Lys Glu Glu 
    1685                 1690                 1695             


Pro Val  Leu Glu Lys Val Thr  Thr Asp Gln Ser Lys  Glu Gly Lys 
    1700                 1705                 1710             


Pro Glu  Asp His Leu Leu Gln  Lys Gly Ala Ser Asn  Thr Gln Leu 
    1715                 1720                 1725             


Leu Leu  Lys Glu Lys Ala Glu  Leu Leu Thr Ser Leu  Glu Val Ser 
    1730                 1735                 1740             


Ala Arg  Lys Asp Cys Val Gly  Ser Lys Glu Ser Ala  Leu Ala Lys 
    1745                 1750                 1755             


Ile Asp  Ala Glu Leu Glu Glu  Val Gly Pro Ser Arg  Arg Val Gly 
    1760                 1765                 1770             


Glu Glu  Thr Val Gly Asp Asn  Ser Pro Ser Ser Val  Val Glu Glu 
    1775                 1780                 1785             


Gln Tyr  Leu Asn Lys Leu Thr  Ser Cys Pro Gln Pro  Leu Asn Glu 
    1790                 1795                 1800             


Thr Ser  Tyr Ser Lys Ile Ala  Leu Asp Gly Lys Thr  Thr Ile Ser 
    1805                 1810                 1815             


Ser Thr  Ser Glu Tyr Glu Arg  Asn Arg Gly Glu Arg  Arg Ser His 
    1820                 1825                 1830             


Lys Lys  Phe Lys Pro Asn Val  Thr Arg Gly Arg Gly  Ser Lys Arg 
    1835                 1840                 1845             


Val Arg  Gly Lys Thr Ser Lys  Lys Glu Pro Arg Ala  Ser Lys Ala 
    1850                 1855                 1860             


Met Leu  Val Thr Leu Arg Ala  Ser Gln Glu Glu Asp  Asp Asp Ala 
    1865                 1870                 1875             


Asp Asp  Phe Glu Ser Asp Tyr  Glu Glu Glu Ser Tyr  His Leu Ala 
    1880                 1885                 1890             


Pro Glu  Glu Val Asn Lys Ala  Pro Val Phe Val Pro  Val Gly Leu 
    1895                 1900                 1905             


Arg Ser  Pro Glu Pro Val Ser  Ala Gln Ile Glu Glu  Thr Met Glu 
    1910                 1915                 1920             


Glu Leu  Glu Ile Thr Val Asn  Val Pro Asp Val Gly  Cys Ile Ala 
    1925                 1930                 1935             


Val Val  Glu His Glu Leu Pro  Asn Thr Asp Val Thr  Thr Glu Glu 
    1940                 1945                 1950             


Met Lys  Gln Glu Glu Asn Leu  Ser Val Pro Phe Glu  Met Thr Thr 
    1955                 1960                 1965             


Ser Glu  His Ile Gln Asp Glu  Pro Gly Thr Asn Asp  Gly Ser Thr 
    1970                 1975                 1980             


Glu Ala  Ala Ile Thr Leu Leu  Thr Met Gly Asp Leu  Val Leu Gln 
    1985                 1990                 1995             


Ser Glu  Ile Ser Ser Glu Gln  Gly Asp Val Gly Val  Cys Ile Ile 
    2000                 2005                 2010             


Pro His  Val His Ser Lys Asp  Lys Ser His Ile Pro  Ser Ser Leu 
    2015                 2020                 2025             


Asp Asn  Val Asn His Lys Ile  Val His Glu Cys Gln  Glu Leu Ser 
    2030                 2035                 2040             


Ser Pro  Val Ile Thr Thr Ser  Pro Ala Ser Phe Glu  Glu Asn Lys 
    2045                 2050                 2055             


Ile Val  Leu Glu Glu Gln Ser  Ser Arg Glu Glu Ile  Ser Leu Met 
    2060                 2065                 2070             


Glu Lys  Val Lys Glu Asn Ala  Thr Pro Thr Arg Asn  Thr Ile Ser 
    2075                 2080                 2085             


Lys Val  Thr Ser Asn Leu Arg  Ile Arg Ser Arg Leu  Ala Lys Pro 
    2090                 2095                 2100             


Lys Pro  Asn Leu Glu Lys Thr  Leu Gly Thr Asn Arg  Leu Asp Asp 
    2105                 2110                 2115             


Tyr Gln  Glu Val Ser Ser Leu  Cys Val Thr Lys Gly  Ala Glu Met 
    2120                 2125                 2130             


Glu Thr  Gln Arg Glu Thr Glu  Lys Asn Ala Ser Lys  Ala Thr Glu 
    2135                 2140                 2145             


Leu Glu  Asn Lys Asn Leu Gly  Pro Val Thr Thr Ala  Glu Asn Lys 
    2150                 2155                 2160             


Asp Gln  Ser Lys Leu Ala Cys  Val His Gly Ile Lys  Gly Thr Ser 
    2165                 2170                 2175             


Ile Ser  Ser Glu Val Asn Leu  Thr Glu Arg Asn Glu  Asn Gln Glu 
    2180                 2185                 2190             


Glu Ser  Ser Gln Glu Val His  Met Leu Ser Val Ala  Pro Val Ala 
    2195                 2200                 2205             


Ser Ser  Glu Thr Gly Pro Cys  Thr Leu Gly Leu Asp  Arg Gly Leu 
    2210                 2215                 2220             


Gly Glu  Asn Ser Val Glu Glu  Pro Gln Ile Lys Asp  Ser Lys Gly 
    2225                 2230                 2235             


Asp Ser  Val Leu Thr Leu Pro  Val Pro Glu Tyr Thr  Pro Thr Ser 
    2240                 2245                 2250             


Ile Pro  Glu Val Gln Gln Glu  Asn Ile Ile Asn Pro  Gln Asp Leu 
    2255                 2260                 2265             


Thr Val  Asn Leu Val Ala Asn  Val Pro Gln Asp Gly  Glu Asp Glu 
    2270                 2275                 2280             


Gln Ala  Phe Ile Leu Thr Leu  Val Glu Ile Pro Ala  Asn Ala Val 
    2285                 2290                 2295             


Glu Glu  Phe Thr Asp Ala Thr  Ala Gln Phe Met Pro  Asn Pro Leu 
    2300                 2305                 2310             


Leu Pro  Ala Pro Ile Leu Val  Lys Ser Val Asn Thr  Glu Glu Arg 
    2315                 2320                 2325             


Gly Asp  Met Ser Ile Cys Leu  Pro Ala Thr Ser Val  Gly Gln Asp 
    2330                 2335                 2340             


Ala Met  Gly Leu Ser Ile Ser  Gly Arg Asp Asn Ser  Lys Lys Pro 
    2345                 2350                 2355             


Pro Asp  Asn Leu Asp Leu Val  Ser Arg Lys Arg Phe  Gln Cys Arg 
    2360                 2365                 2370             


Leu Asp  Lys Asn Asp His Ile  Pro Pro Ala Lys Lys  Arg Ser Leu 
    2375                 2380                 2385             


Thr Leu  Arg Asp Asp Cys Gln  Glu Tyr Thr Thr Glu  Val His Ser 
    2390                 2395                 2400             


Lys Glu  Leu Thr Asn Val Phe  Glu Glu Thr Gly Glu  Ser His Lys 
    2405                 2410                 2415             


Gly Gln  Asp Ile Phe Leu Thr  Ser Gly Ser Thr Leu  Thr Thr Pro 
    2420                 2425                 2430             


Glu Pro  Gln Arg Gln Gln Val  Glu Ala Ala Phe Gln  Ser Arg Gly 
    2435                 2440                 2445             


Ser Arg  Ser Pro Asp Ala Cys  Met Asp Lys Asn Val  Pro Gln Leu 
    2450                 2455                 2460             


Pro Gln  Asp Glu Met Ile Val  Ser Asp Lys Glu Glu  Arg Thr Asp 
    2465                 2470                 2475             


Ala Ala  Pro Lys Ser Gln Gln  Met Asp Ser Arg Thr  Ser Ser Ser 
    2480                 2485                 2490             


Lys Ala  Ser Leu Ser Arg Pro  Gly Arg Arg Pro Leu  Gly Phe Leu 
    2495                 2500                 2505             


Ser Leu  Ile Cys Ser Lys Asn  Ser Leu Glu Ser Asp  Glu Pro Met 
    2510                 2515                 2520             


Gln Val  His Ser Lys Lys Arg  Leu Lys Pro Leu Ile  Pro Gly Leu 
    2525                 2530                 2535             


Arg Lys  Lys Leu Lys Arg Ser  Asn Pro Phe Asn Glu  Ser Gln Glu 
    2540                 2545                 2550             


Lys Asn  Arg Glu Ser Ser Asp  Leu Leu Pro Ser Pro  Ser Val Ile 
    2555                 2560                 2565             


Thr Thr  Gln Ser Glu Asn Ile  Ser Ser Ser Ala Thr  Gln Val Ser 
    2570                 2575                 2580             


Cys Asp  Gln Pro Leu Leu Lys  Glu Gly Tyr Lys Ser  Ala Gln Lys 
    2585                 2590                 2595             


Arg Ala  Pro Gln Gly Glu Ala  Thr Thr Val Ser Glu  Tyr Phe Phe 
    2600                 2605                 2610             


Asn Asp  Ile Phe Ile Glu Val  Asp Glu Thr Glu 
    2615                 2620                 


<210>  1039
<211>  2329
<212>  DNA
<213>  Homosapiens

<400>  1039
aggacctgag ctcagcttcc gccccagcca gggaagcggc aggggaaagc accggctcca     60

ggccagcgtg ggccgctctc tcgctcggtg cccgccgcca tgtgggccgt cctgaggtta    120

gccctgcggc cgtgtgcccg cgcctctccc gccgggccgc gcgcctatca cggggactcg    180

gtggcctcgc tgggcaccca gccggacttg ggctctgccc tctaccagga gaactacaag    240

cagatgaaag cactagtaaa tcagctccat gaacgagtgg agcatataaa actaggaggt    300

ggtgagaaag cccgagcact tcacatatca agaggaaaac tattgcccag agaaagaatt    360

gacaatctca tagacccagg gtctccattt ctggaattat cccagtttgc aggttaccag    420

ttatatgaca atgaggaggt gccaggaggt ggcattatta caggcattgg aagagtatca    480

ggagtagaat gcatgattat tgccaatgat gccaccgtca aaggaggtgc ctactaccca    540

gtgactgtga aaaaacaatt acgggcccaa gaaattgcca tgcaaaacag gctcccctgc    600

atctacttag ttgattcggg aggagcatac ttacctcgac aagcagatgt gtttccagat    660

cgagaccact ttggccgtac attctataat caggcaatta tgtcttctaa aaatattgca    720

cagatcgcag tggtcatggg ctcctgcacc gcaggaggag cctatgtgcc tgccatggct    780

gatgaaaaca tcattgtacg caagcagggt accattttct tggcaggacc ccccttggtt    840

aaagcggcaa ctggggaaga agtatctgct gaggatcttg gaggtgctga tcttcattgc    900

agaaagtctg gagtaagtga ccactgggct ttggatgatc atcatgccct tcacttaact    960

aggaaggttg tgaggaatct aaattatcag aagaaattgg atgtcaccat tgaaccttct   1020

gaagagcctt tatttcctgc tgatgaattg tatggaatag ttggtgctaa ccttaagagg   1080

agctttgatg tccgagaggt cattgctaga atcgtggatg gaagcagatt cactgagttc   1140

aaagcctttt atggagacac attagttaca ggatttgctc gaatatttgg gtacccagta   1200

ggtatcgttg gaaacaacgg agttctcttt tctgaatctg caaaaaaggg tactcacttt   1260

gtccagttat gctgccaaag aaatattcct ctgctgttcc ttcaaaacat tactggattt   1320

atggttggta gagagtatga agctgaagga attgccaagg atggtgccaa gatggtggcc   1380

gctgtggcct gtgcccaagt gcctaagata accctcatca ttgggggctc ctatggagcc   1440

ggaaactatg ggatgtgtgg cagagcgtat agcccaagat ttctctacat ttggccaaat   1500

gctcgtatct cagtgatggg aggagagcag gcagccaatg tgttggccac gataacaaag   1560

gaccaaagag cccgggaagg aaagcagttc tccagtgctg atgaagcggc tttaaaagag   1620

cccatcatta agaagtttga agaggaagga aacccttact attccagcgc aagggtatgg   1680

gatgatggga tcattgatcc agcagacacc agactggtct tgggtctcag ttttagtgca   1740

gccctcaacg caccaataga gaagactgac ttcggtatct tcaggatgta actggaataa   1800

aggatgtttt ctgttggaca tgtactgaaa attaacacat gtagtagcct taaaatttta   1860

gacttctcga acatgaggct gttacagtaa tttttttaac actgtgcatt gtacttttct   1920

accttaaaaa aatcagtgag gatatttatt taatgaacat caattccttt taaattttct   1980

tagagaaatt tctctgtggc tcagttttac cacccataaa gcggagacag taatttatgg   2040

ttatcctttc tgacccacaa agtatgaaaa gttctgtaat ctgtaaactc agttctgtaa   2100

tctgtattat tgagatgatt aatataaagt tgtattttca ctgaaatgat tgttttgctg   2160

gttatgcttg gtgatatttt agcgggctta tttttgaaag gcatctgtta cttcagttgc   2220

ataaagtgcc ctcacactgc tgtgcagcca ttaccaccat tcatctccag aatttgttct   2280

cagtcccaaa ctgaaactat accattcaaa caacagcgct ccccatttc               2329


<210>  1040
<211>  563
<212>  PRT
<213>  Homosapiens

<400>  1040

Met Trp Ala Val Leu Arg Leu Ala Leu Arg Pro Cys Ala Arg Ala Ser 
1               5                   10                  15      


Pro Ala Gly Pro Arg Ala Tyr His Gly Asp Ser Val Ala Ser Leu Gly 
            20                  25                  30          


Thr Gln Pro Asp Leu Gly Ser Ala Leu Tyr Gln Glu Asn Tyr Lys Gln 
        35                  40                  45              


Met Lys Ala Leu Val Asn Gln Leu His Glu Arg Val Glu His Ile Lys 
    50                  55                  60                  


Leu Gly Gly Gly Glu Lys Ala Arg Ala Leu His Ile Ser Arg Gly Lys 
65                  70                  75                  80  


Leu Leu Pro Arg Glu Arg Ile Asp Asn Leu Ile Asp Pro Gly Ser Pro 
                85                  90                  95      


Phe Leu Glu Leu Ser Gln Phe Ala Gly Tyr Gln Leu Tyr Asp Asn Glu 
            100                 105                 110         


Glu Val Pro Gly Gly Gly Ile Ile Thr Gly Ile Gly Arg Val Ser Gly 
        115                 120                 125             


Val Glu Cys Met Ile Ile Ala Asn Asp Ala Thr Val Lys Gly Gly Ala 
    130                 135                 140                 


Tyr Tyr Pro Val Thr Val Lys Lys Gln Leu Arg Ala Gln Glu Ile Ala 
145                 150                 155                 160 


Met Gln Asn Arg Leu Pro Cys Ile Tyr Leu Val Asp Ser Gly Gly Ala 
                165                 170                 175     


Tyr Leu Pro Arg Gln Ala Asp Val Phe Pro Asp Arg Asp His Phe Gly 
            180                 185                 190         


Arg Thr Phe Tyr Asn Gln Ala Ile Met Ser Ser Lys Asn Ile Ala Gln 
        195                 200                 205             


Ile Ala Val Val Met Gly Ser Cys Thr Ala Gly Gly Ala Tyr Val Pro 
    210                 215                 220                 


Ala Met Ala Asp Glu Asn Ile Ile Val Arg Lys Gln Gly Thr Ile Phe 
225                 230                 235                 240 


Leu Ala Gly Pro Pro Leu Val Lys Ala Ala Thr Gly Glu Glu Val Ser 
                245                 250                 255     


Ala Glu Asp Leu Gly Gly Ala Asp Leu His Cys Arg Lys Ser Gly Val 
            260                 265                 270         


Ser Asp His Trp Ala Leu Asp Asp His His Ala Leu His Leu Thr Arg 
        275                 280                 285             


Lys Val Val Arg Asn Leu Asn Tyr Gln Lys Lys Leu Asp Val Thr Ile 
    290                 295                 300                 


Glu Pro Ser Glu Glu Pro Leu Phe Pro Ala Asp Glu Leu Tyr Gly Ile 
305                 310                 315                 320 


Val Gly Ala Asn Leu Lys Arg Ser Phe Asp Val Arg Glu Val Ile Ala 
                325                 330                 335     


Arg Ile Val Asp Gly Ser Arg Phe Thr Glu Phe Lys Ala Phe Tyr Gly 
            340                 345                 350         


Asp Thr Leu Val Thr Gly Phe Ala Arg Ile Phe Gly Tyr Pro Val Gly 
        355                 360                 365             


Ile Val Gly Asn Asn Gly Val Leu Phe Ser Glu Ser Ala Lys Lys Gly 
    370                 375                 380                 


Thr His Phe Val Gln Leu Cys Cys Gln Arg Asn Ile Pro Leu Leu Phe 
385                 390                 395                 400 


Leu Gln Asn Ile Thr Gly Phe Met Val Gly Arg Glu Tyr Glu Ala Glu 
                405                 410                 415     


Gly Ile Ala Lys Asp Gly Ala Lys Met Val Ala Ala Val Ala Cys Ala 
            420                 425                 430         


Gln Val Pro Lys Ile Thr Leu Ile Ile Gly Gly Ser Tyr Gly Ala Gly 
        435                 440                 445             


Asn Tyr Gly Met Cys Gly Arg Ala Tyr Ser Pro Arg Phe Leu Tyr Ile 
    450                 455                 460                 


Trp Pro Asn Ala Arg Ile Ser Val Met Gly Gly Glu Gln Ala Ala Asn 
465                 470                 475                 480 


Val Leu Ala Thr Ile Thr Lys Asp Gln Arg Ala Arg Glu Gly Lys Gln 
                485                 490                 495     


Phe Ser Ser Ala Asp Glu Ala Ala Leu Lys Glu Pro Ile Ile Lys Lys 
            500                 505                 510         


Phe Glu Glu Glu Gly Asn Pro Tyr Tyr Ser Ser Ala Arg Val Trp Asp 
        515                 520                 525             


Asp Gly Ile Ile Asp Pro Ala Asp Thr Arg Leu Val Leu Gly Leu Ser 
    530                 535                 540                 


Phe Ser Ala Ala Leu Asn Ala Pro Ile Glu Lys Thr Asp Phe Gly Ile 
545                 550                 555                 560 


Phe Arg Met 
            


<210>  1041
<211>  908
<212>  DNA
<213>  Homosapiens

<400>  1041
ggttgacccg ggccctcctc cacaccccct tccttcttcg cctcctccct ctttcctgca     60

cgggggctcg ggctcactat aaaaggtggg agcgcgtggt gccccagcaa cgacgagttt    120

cagaacgatg gagagctccc gcgtgaggct gctgcccctc ctgggcgccg ccctgctgct    180

gatgctacct ctgttgggta cccgtgccca ggaggacgcc gagctccagc cccgagccct    240

ggacatctac tctgccgtgg atgatgcctc ccacgagaag gagctgatcg aagcgctgca    300

agaagtcttg aagaagctca agagtaaacg tgttcccatc tatgagaaga agtatggcca    360

agtccccatg tgtgacgccg gtgagcagtg tgcagtgagg aaaggggcaa ggatcgggaa    420

gctgtgtgac tgtccccgag gaacctcctg caattccttc ctcctgaagt gcttatgaag    480

gggcgtccat tctcctccat acatccccat ccctctactt tccccagagg accacacctt    540

cctccctgga gtttggctta agcaacagat aaagttttta ttttcctctg aagggaaagg    600

gctcttttcc tgctgtttca aaaataaaag aacacattag atgttactgt gtgaagaata    660

atgccttgta tggtgttgat acgtgtgtga agtattctta ttttatttgt ctgacaaact    720

cttgtgtacc tttgtgtaaa gaagggaagc tttgtttgaa aattgtattt ttgtatgtgg    780

catggcagaa tgaaaattag atctagctaa tctcggtaga tgtcattaca acctggaaaa    840

taaatcaccc taagtgacac aaattgaagc atgtacaaat tatacataat aaagtgtttt    900

taataatt                                                             908


<210>  1042
<211>  116
<212>  PRT
<213>  Homosapiens

<400>  1042

Met Glu Ser Ser Arg Val Arg Leu Leu Pro Leu Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Met Leu Pro Leu Leu Gly Thr Arg Ala Gln Glu Asp Ala Glu 
            20                  25                  30          


Leu Gln Pro Arg Ala Leu Asp Ile Tyr Ser Ala Val Asp Asp Ala Ser 
        35                  40                  45              


His Glu Lys Glu Leu Ile Glu Ala Leu Gln Glu Val Leu Lys Lys Leu 
    50                  55                  60                  


Lys Ser Lys Arg Val Pro Ile Tyr Glu Lys Lys Tyr Gly Gln Val Pro 
65                  70                  75                  80  


Met Cys Asp Ala Gly Glu Gln Cys Ala Val Arg Lys Gly Ala Arg Ile 
                85                  90                  95      


Gly Lys Leu Cys Asp Cys Pro Arg Gly Thr Ser Cys Asn Ser Phe Leu 
            100                 105                 110         


Leu Lys Cys Leu 
        115     


<210>  1043
<211>  6250
<212>  DNA
<213>  Homosapiens

<400>  1043
atagtaaagg tcggcccgcg caagatggcg gcccccttgg aactcagttg ctggggaggc     60

ggctggggac tcccatcggt tcacagcgag tccctggtgg tgatggctta tgccaaattt    120

tctggtgcac ccttgaaagt caatgtgata gataacacct ggagaggttc aaaaggcgat    180

gtaccaattt tgacaactga agacgacatg gtttctcagc cagcaaaaat actaaacttt    240

ttaagaaaac agaaatataa tgctgattat gaactctcag caaaacaagg ggcagataca    300

ttggcttata ttgctctcct cgaagagaag cttctccctg cagtgcttca cacattctgg    360

gttgagagtg acaattactt tactgtgaca aagccatggt ttgcttcaca aattcctttt    420

cctttgagtt tgatcctgcc tggaagaatg tctcagcaaa tcttatcaag tcgtgcagga    480

acccatatgt taagaaaatg agctttgtag tcaaaagact catctaattt gagctgagtg    540

gagctcagct gtgtttgacc cacatcctcc caatttgttc tgtatttagg tagttattta    600

tacaagcgtc tttaagtcat tctaaatatt ttttcttgaa agttttaact aagtgagaaa    660

taaggtagtc ttcaaaatct tggtcatctg tttggatgag ggaaagtacc tcatgagttg    720

cacattactt ctacaacagg gtgtgtgtgt gtgtgtttgt gtgtgtcagt catcttcaaa    780

ggcagattat tagattccag caatctgaaa tctattattc cagcagtctg gaatctaaat    840

atgttatatt ggaaatcatg actgtgagac tttattgtcc tctaggatgg atgtatattg    900

gagaagggtg gttagcacat tcatcagaca tctgcttatg ctgtggtcaa ggccagtcat    960

ttttaattta tatcagattt atatcagacc ctccaaaaag tatttgaaat atattacagt   1020

tataacgtac aagtacatta catgtatatt acaagtatat tacatgtaaa acaggacaat   1080

ttaaaaattt taaattttaa agaattaaaa attttaaaaa tttaaattaa aaaaattaaa   1140

aatttataga accatatcaa cactgacaga ttctaaaatt aagtagtaaa tttaactcca   1200

agtttctcca tgggcaaagt caaaagataa tgctaggtta tgtcaatttt tcttttcaac   1260

aaaactgcta atgtctatta ggaagaaaaa tgtgtttaaa gttttacagg aacgtggagc   1320

tcatgttctt ctgatatgta gactttgata aagaagcata ctgtaatgtt ttatgaactg   1380

aaattttaat caaaaggggt cattttagaa taacaagtat tattcttttt tagtagaggg   1440

aatgactgtc aatatgattt atttgttttt gtgtcatccc tactttgaac tgccgttagc   1500

cttacattct cactatagtc cataatgctt ccagatcacc ttttctaaga tgcaacatgt   1560

gagtttagtg agagtttata tgttgggtta cttagttgag ctatttatgt ataagtaaat   1620

gagatgacag gaagctgtaa ctgagcacaa agtaccttag ggagcagcca cacatacagg   1680

aagctcttag aaaagaactt tttttttttt tttgagacag agtttcactc ttgttgccca   1740

ggctggagtg cagtagcgca gtctcggctc actgcaacct ctacctcctg ggttcaagca   1800

agtctcctgt ctcagcctcc caagtagctg ggattacagg catgtgccac catgcccagc   1860

taattttgtt ttttttttag tcgagacggg gtttcaccat gttgctcagg ctggtcttga   1920

actcctgacc tcaagtgatt cacctgcctc ggcctcccaa agtgctggga ttacaggcgt   1980

gagccactgc gcccggccaa aaagaacatt ttgtcaatct gaacagagca cagaacattt   2040

tttcagactg aacagactgt tggaccagcc tgtcatgata tgttttagat aaagtttgag   2100

tgagttcatt gggataaatg gtccacaatc ttaaacagaa tactgtgagc caatgccttt   2160

tggaagtaat ggtggaggat aatatgatta aagggaacat gcttgtgttt atttttgttg   2220

gtagtatatg attagaaaaa ctagataatt cccataagat gaagatcttc catgaacaaa   2280

ctaccatcaa tcatccatca gattgatttt tttttttttt ttaagtaaca ctaaagaagc   2340

tgtaaagaac attgaaggtg gtcattcctt caaaactgtg ttttgaccac acaaggtggg   2400

cattaacaaa ccaaatttca acttaagttt gtttgtatta tattgggggt gctgcgagac   2460

tggagatttt ataaaagcaa gcatttttat ttccatttat aatttctatt caatattgct   2520

agatatatta acatgaagga atggggaagc ttatttcaat caaagctaaa attttcagaa   2580

gtctgtaaaa atggaaaaac accattgaaa gaggcagaaa caggtaaggg ggatagtatc   2640

ttagaaaacc tgttggttaa ggcagctgca tgtgataaaa gtggtacttg aacttggtag   2700

tgtttcctta gaacctcctc caaaaatatg catttaccag gcttgttaca attttttgac   2760

agtttttcat caactgtcaa aaacttcaac ccttttaaaa cctagatata aatgcttaca   2820

tgtaaagaaa ggaagctaag cagtgggtac ctgggatctc tctgaactat ttttataact   2880

tcttgtgagt cttaagtatt tcaaaataaa agtggtttta aagtaaattc atagattaaa   2940

tgtatcatta tctatatata aaccatgatt taaaacttta attttctaaa catagtattc   3000

aacttagttg aataaatata tgatagaagt taaatagaat ttttatttca ttcttaagaa   3060

aaactcatgt ttgtaacaaa tgatatctaa agatctattt tgccttacca gaaaagaaaa   3120

aaaaaaccct aaaaccaaaa actccttttc cctaggaagt caaaaatgct gtgatttaaa   3180

atatctaatt atattttttt ctttctatgg tagtggggtt tacttctgag gataaaatat   3240

tttgaaaaag ctctgtccct tgacatggta gttctcccgt gccttgtact tgttctctct   3300

ccatatgcac agtgtgacaa gatgctcacc tttaatgaag aaggtgtagc ttttcgtttt   3360

aagctgtaat tgtctttgtc ttgattggct atttttataa ctgaaatcct gagcaacaga   3420

gataatttgg gtggtaatga tcatcttttg tatatgttct tgatgttaag aaatattttt   3480

tgctgccatt cagctttgtg gaatttatgt ttacttttca atattttcat atttcttaac   3540

cagattttaa agaaatttgt tgttagttac gtgaaatcaa aggtcaggtc agtaagccca   3600

ttatcctcaa acttgaagtt tcgttggatg ttcaaaatgc taatttttgc agagatataa   3660

ggataaatta gttttagttt gtgttcttaa gggtttgcaa aataatttgg ctcccaaact   3720

cttgttgggg tgtagtgttt gctaggagcc caggatacct gccctggact taaattgtga   3780

ttgaagtgga gaggtactct aggaatttaa aaagacacaa aattattttt ttccagacta   3840

gtgtgccatg gatttctgat aagaattaac attcttgaac aaaggtatca gaaagggtaa   3900

ctcgagttga aggtttgtga atagaagggg aaatgtgata gaagattatt cagaacaaaa   3960

taagtagaca aaataacaaa agacaggaaa ataagtctct ttgtatcctt attaatcatt   4020

tgaaattatg ctataatatt ttttaaaact cacctgtttg gttctgggtg aagcagttcc   4080

tgaaggagtg ttttgtcaga atatattgtt aggagaatag agggttctgt ggccaagtaa   4140

gtttgggaaa tagtgggtta gacaaagttg agttactgtt ggcctttcag acctttgata   4200

cgctaatgtg cattttaaat ctccaagaag cacctctatt ttatacatca tttccctaat   4260

ttattttaat atggatttct tgtttttgtt ttcttgagac ggagtcttgg tcttgtcacc   4320

caggctggag tgcagtggca cgatctcggc tcactacaac ctccgcctcc caggttcaag   4380

cgattctcct gcctcagcct cccaatttac tgggattaca ggcacctgcc accacgccca   4440

gctaattttt gtatttttag tagagatggg gtttcaccat gttgaccagg ctgattttga   4500

actcctgacc tcaggtgatt ctgcccgcct caccctccca cagtgctgga attataggta   4560

tgagccactg tccccggcca gattttttta aaagtaggta tcttgtggga tttatgttct   4620

gagagataca cctaaggaaa tgctgcccta cagtgttttt gctagttcat actcattaca   4680

aaggtttctt gttgttgggt gcccctctag ccagtggtag taaaatggga agagacaggt   4740

caagactccc ttggaccatg gcattgagag agggatggct gtcggcatag atatgttggt   4800

tatttaggca tttgtgaggg aggcccctgg ctcttccagc ctgtttcctt aggatcccag   4860

ttggccggga acagctgtac aagggtctgc tgaactggtg gtttcagcag actacccagt   4920

tcctaagcat ccatgagaca gagggaacca acttgtattt ccagaacaat tttccaaacc   4980

ttttctggct gtactttaaa agtgccaaaa aggcaatggg tgtttatgac actaaagtca   5040

catacaagct agtatgatac atacatcata gaaagcttat agttgctcag tgacaaagca   5100

aaggaagttt aatattttcc agttttgttc attaccgaag acagtctacg gttcatagtt   5160

ttcactaaat tctaagcaga ttctatatcc taaaacattt aaacctcact aggcctgcga   5220

ttttgagagg gttagctaaa tatgtttggt atcacttcag agtctaaaac cagattacta   5280

atcgtgtgta aggaggcatt ttgtgtgtct ttgcaatgta tacaattgga ttatttggaa   5340

caccattttg aatgtgtatt tgagagaaag ctcgcctgtg ggttttgagt tgtggtgtaa   5400

tggtgaacat gtagccacgt gaaaggccgt tggatctttg ttctgattct tcagtcgtct   5460

tcttgcaaat tcagagaaat gtcttttaat catttcgttt acatatccca gatccttgga   5520

aatcatgaaa aataacttgc cagagtttgc atcagccctc agtaagtcat gaaccataga   5580

gaaggtcatg gggccattta ttctttggac cactggctac ttctgaagtt ctggcttcct   5640

tctctctagg aggagtcgtg tattcaagct tttaagttaa atgcataaaa atgagtttta   5700

cttctcttct gacttgattt ttaattttat gaaatgggaa ataatgtttt tccatttttc   5760

tgttcatttt gaagtgggaa tttgaggtgt ttgtaatgtc atgttactgt tctgaaagat   5820

tgacagtaaa gaagacaaga aatatatgta tgtagtatgc atattagttt tgtcccacca   5880

agcctatctt tgaatggcaa acattttaaa aacatctgtt ctagttgcac aactactcta   5940

gcttctttat aaagtaaaca atcttaaagt aagcaatgtt ggccataatt tcaatattct   6000

agccttgccg agtgtgaata tattttactc agagactatg tacaaataca ctaaagtggt   6060

gatggtgatc aatattgtaa agaatttatt ctgataaatg agaaactgga tataatgtca   6120

aaatagctat tttctcaata aaaatctcaa atctcaaaaa aaaaaaaaaa aaaaaaaaaa   6180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaagt aaaaaaaaaa aaaaaaaaaa   6240

aaaaaaaaaa                                                          6250


<210>  1044
<211>  158
<212>  PRT
<213>  Homosapiens

<400>  1044

Met Ala Ala Pro Leu Glu Leu Ser Cys Trp Gly Gly Gly Trp Gly Leu 
1               5                   10                  15      


Pro Ser Val His Ser Glu Ser Leu Val Val Met Ala Tyr Ala Lys Phe 
            20                  25                  30          


Ser Gly Ala Pro Leu Lys Val Asn Val Ile Asp Asn Thr Trp Arg Gly 
        35                  40                  45              


Ser Lys Gly Asp Val Pro Ile Leu Thr Thr Glu Asp Asp Met Val Ser 
    50                  55                  60                  


Gln Pro Ala Lys Ile Leu Asn Phe Leu Arg Lys Gln Lys Tyr Asn Ala 
65                  70                  75                  80  


Asp Tyr Glu Leu Ser Ala Lys Gln Gly Ala Asp Thr Leu Ala Tyr Ile 
                85                  90                  95      


Ala Leu Leu Glu Glu Lys Leu Leu Pro Ala Val Leu His Thr Phe Trp 
            100                 105                 110         


Val Glu Ser Asp Asn Tyr Phe Thr Val Thr Lys Pro Trp Phe Ala Ser 
        115                 120                 125             


Gln Ile Pro Phe Pro Leu Ser Leu Ile Leu Pro Gly Arg Met Ser Gln 
    130                 135                 140                 


Gln Ile Leu Ser Ser Arg Ala Gly Thr His Met Leu Arg Lys 
145                 150                 155             


<210>  1045
<211>  3365
<212>  DNA
<213>  Homosapiens

<400>  1045
ctggtccgtc caggctcctt cccatcctca cacccgcgcc tttctccctg cggccccggc     60

tcgctgctcc agctgcccag ctcttccccc gcccggccgc accataaagc gcccggccgc    120

tgccgcggag cccagcagcc agctccccag caccgcacgg cggggacgcg agcgcgcccc    180

cgacggcagc ccggacgccg agcacgggtc acctgcggcg ccggcccggg cgccgaccga    240

ggttcaacgc acggcccggg gacccccagg cggggccaac gccgccgtcg cccccggcct    300

cgcggggagc aggaagagcc aacatgctgg ccccgcgcgg agccgccgtc ctcctgctgc    360

acctggtcct gcagcggtgg ctagcggcag gcgcccaggc caccccccag gtctttgacc    420

ttctcccatc ttccagtcag aggctaaacc caggcgctct gctgccagtc ctgacagacc    480

ccgccctgaa tgatctctat gtgatttcca ccttcaagct gcagactaaa agttcagcca    540

ccatcttcgg tctttactct tcaactgaca acagtaaata ttttgaattt actgtgatgg    600

gacgcttaaa caaagccatc ctccgttacc tgaagaacga tgggaaggtg catttggtgg    660

ttttcaacaa cctgcagctg gcagacggaa ggcggcacag gatcctcctg aggctgagca    720

atttgcagcg aggggccggc tccctagagc tctacctgga ctgcatccag gtggattccg    780

ttcacaatct ccccagggcc tttgctggcc cctcccagaa acctgagacc attgaattga    840

ggactttcca gaggaagcca caggacttct tggaagagct gaagctggtg gtgagaggct    900

cactgttcca ggtggccagc ctgcaagact gcttcctgca gcagagtgag ccactggctg    960

ccacaggcac aggggacttt aaccggcagt tcttgggtca aatgacacaa ttaaaccaac   1020

tcctgggaga ggtgaaggac cttctgagac agcaggttaa ggaaacatca tttttgcgaa   1080

acaccatagc tgaatgccag gcttgcggtc ctctcaagtt tcagtctccg accccaagca   1140

cggtggtgcc cccggctccc cctgcaccgc caacacgccc acctcgtcgg tgtgactcca   1200

acccatgttt ccgaggtgtc caatgtaccg acagtagaga tggcttccag tgtgggccct   1260

gccccgaggg ctacacagga aacgggatca cctgtattga tgttgatgag tgcaaatacc   1320

atccctgcta cccgggcgtg cactgcataa atttgtctcc tggcttcaga tgtgacgcct   1380

gcccagtggg cttcacaggg cccatggtgc agggtgttgg gatcagtttt gccaagtcaa   1440

acaagcaggt ctgcactgac attgatgagt gtcgaaatgg agcgtgcgtt cccaactcga   1500

tctgcgttaa tactttggga tcttaccgct gtgggccttg taagccgggg tatactggtg   1560

atcagataag gggatgcaaa gcggaaagaa actgcagaaa cccagagctg aacccttgca   1620

gtgtgaatgc ccagtgcatt gaagagaggc agggggatgt gacatgtgtg tgtggagtcg   1680

gttgggctgg agatggctat atctgtggaa aggatgtgga catcgacagt taccccgacg   1740

aagaactgcc atgctctgcc aggaactgta aaaaggacaa ctgcaaatat gtgccaaatt   1800

ctggccaaga agatgcagac agagatggca ttggcgacgc ttgtgacgag gatgctgacg   1860

gagatgggat cctgaatgag caggataact gtgtcctgat tcataatgtg gaccaaagga   1920

acagcgataa agatatcttt ggggatgcct gtgataactg cctgagtgtc ttaaataacg   1980

accagaaaga caccgatggg gatggaagag gagatgcctg tgatgatgac atggatggag   2040

atggaataaa aaacattctg gacaactgcc caaaatttcc caatcgtgac caacgggaca   2100

aggatggtga tggtgtgggg gatgcctgtg acagttgtcc tgatgtcagc aaccctaacc   2160

agtctgatgt ggataatgat ctggttgggg actcctgtga caccaatcag gacagtgatg   2220

gagatgggca ccaggacagc acagacaact gccccaccgt cattaacagt gcccagctgg   2280

acaccgataa ggatggaatt ggtgacgagt gtgatgatga tgatgacaat gatggtatcc   2340

cagacctggt gccccctgga ccagacaact gccggctggt ccccaaccca gcccaggagg   2400

atagcaacag cgacggagtg ggagacatct gtgagtctga ctttgaccag gaccaggtca   2460

tcgatcggat cgacgtctgc ccagagaacg cagaggtcac cctgaccgac ttcagggctt   2520

accagaccgt ggtcctggat cctgaagggg atgcccagat cgatcccaac tgggtggtcc   2580

tgaaccaggg catggagatt gtacagacca tgaacagtga tcctggcctg gcagtggggt   2640

acacagcttt taatggagtt gacttcgaag ggaccttcca tgtgaatacc cagacagatg   2700

atgactatgc aggctttatc tttggctacc aagatagctc cagcttctac gtggtcatgt   2760

ggaagcagac ggagcagaca tattggcaag ccaccccatt ccgagcagtt gcagaacctg   2820

gcattcagct caaggctgtg aagtctaaga caggtccagg ggagcatctc cggaactccc   2880

tgtggcacac gggggacacc agtgaccagg tcaggctgct gtggaaggac tccaggaatg   2940

tgggctggaa ggacaaggtg tcctaccgct ggttcctaca gcacaggccc caggtgggct   3000

acatcagggt acgattttat gaaggctctg agttggtggc tgactctggc gtcaccatag   3060

acaccacaat gcgtggaggc cgacttggcg ttttctgctt ctctcaagaa aacatcatct   3120

ggtccaacct caagtatcgc tgcaatgaca ccatccctga ggacttccaa gagtttcaaa   3180

cccagaattt cgaccgcttc gataattaaa ccaaggaagc aatctgtaac tgcttttcgg   3240

aacactaaaa ccatatatat tttaacttca attttcttta gcttttacca acccaaatat   3300

atcaaaacgt tttatgtgaa tgtggcaata aaggagaaga gatcattttt aaaaaaaaaa   3360

aaaaa                                                               3365


<210>  1046
<211>  961
<212>  PRT
<213>  Homosapiens

<400>  1046

Met Leu Ala Pro Arg Gly Ala Ala Val Leu Leu Leu His Leu Val Leu 
1               5                   10                  15      


Gln Arg Trp Leu Ala Ala Gly Ala Gln Ala Thr Pro Gln Val Phe Asp 
            20                  25                  30          


Leu Leu Pro Ser Ser Ser Gln Arg Leu Asn Pro Gly Ala Leu Leu Pro 
        35                  40                  45              


Val Leu Thr Asp Pro Ala Leu Asn Asp Leu Tyr Val Ile Ser Thr Phe 
    50                  55                  60                  


Lys Leu Gln Thr Lys Ser Ser Ala Thr Ile Phe Gly Leu Tyr Ser Ser 
65                  70                  75                  80  


Thr Asp Asn Ser Lys Tyr Phe Glu Phe Thr Val Met Gly Arg Leu Asn 
                85                  90                  95      


Lys Ala Ile Leu Arg Tyr Leu Lys Asn Asp Gly Lys Val His Leu Val 
            100                 105                 110         


Val Phe Asn Asn Leu Gln Leu Ala Asp Gly Arg Arg His Arg Ile Leu 
        115                 120                 125             


Leu Arg Leu Ser Asn Leu Gln Arg Gly Ala Gly Ser Leu Glu Leu Tyr 
    130                 135                 140                 


Leu Asp Cys Ile Gln Val Asp Ser Val His Asn Leu Pro Arg Ala Phe 
145                 150                 155                 160 


Ala Gly Pro Ser Gln Lys Pro Glu Thr Ile Glu Leu Arg Thr Phe Gln 
                165                 170                 175     


Arg Lys Pro Gln Asp Phe Leu Glu Glu Leu Lys Leu Val Val Arg Gly 
            180                 185                 190         


Ser Leu Phe Gln Val Ala Ser Leu Gln Asp Cys Phe Leu Gln Gln Ser 
        195                 200                 205             


Glu Pro Leu Ala Ala Thr Gly Thr Gly Asp Phe Asn Arg Gln Phe Leu 
    210                 215                 220                 


Gly Gln Met Thr Gln Leu Asn Gln Leu Leu Gly Glu Val Lys Asp Leu 
225                 230                 235                 240 


Leu Arg Gln Gln Val Lys Glu Thr Ser Phe Leu Arg Asn Thr Ile Ala 
                245                 250                 255     


Glu Cys Gln Ala Cys Gly Pro Leu Lys Phe Gln Ser Pro Thr Pro Ser 
            260                 265                 270         


Thr Val Val Pro Pro Ala Pro Pro Ala Pro Pro Thr Arg Pro Pro Arg 
        275                 280                 285             


Arg Cys Asp Ser Asn Pro Cys Phe Arg Gly Val Gln Cys Thr Asp Ser 
    290                 295                 300                 


Arg Asp Gly Phe Gln Cys Gly Pro Cys Pro Glu Gly Tyr Thr Gly Asn 
305                 310                 315                 320 


Gly Ile Thr Cys Ile Asp Val Asp Glu Cys Lys Tyr His Pro Cys Tyr 
                325                 330                 335     


Pro Gly Val His Cys Ile Asn Leu Ser Pro Gly Phe Arg Cys Asp Ala 
            340                 345                 350         


Cys Pro Val Gly Phe Thr Gly Pro Met Val Gln Gly Val Gly Ile Ser 
        355                 360                 365             


Phe Ala Lys Ser Asn Lys Gln Val Cys Thr Asp Ile Asp Glu Cys Arg 
    370                 375                 380                 


Asn Gly Ala Cys Val Pro Asn Ser Ile Cys Val Asn Thr Leu Gly Ser 
385                 390                 395                 400 


Tyr Arg Cys Gly Pro Cys Lys Pro Gly Tyr Thr Gly Asp Gln Ile Arg 
                405                 410                 415     


Gly Cys Lys Ala Glu Arg Asn Cys Arg Asn Pro Glu Leu Asn Pro Cys 
            420                 425                 430         


Ser Val Asn Ala Gln Cys Ile Glu Glu Arg Gln Gly Asp Val Thr Cys 
        435                 440                 445             


Val Cys Gly Val Gly Trp Ala Gly Asp Gly Tyr Ile Cys Gly Lys Asp 
    450                 455                 460                 


Val Asp Ile Asp Ser Tyr Pro Asp Glu Glu Leu Pro Cys Ser Ala Arg 
465                 470                 475                 480 


Asn Cys Lys Lys Asp Asn Cys Lys Tyr Val Pro Asn Ser Gly Gln Glu 
                485                 490                 495     


Asp Ala Asp Arg Asp Gly Ile Gly Asp Ala Cys Asp Glu Asp Ala Asp 
            500                 505                 510         


Gly Asp Gly Ile Leu Asn Glu Gln Asp Asn Cys Val Leu Ile His Asn 
        515                 520                 525             


Val Asp Gln Arg Asn Ser Asp Lys Asp Ile Phe Gly Asp Ala Cys Asp 
    530                 535                 540                 


Asn Cys Leu Ser Val Leu Asn Asn Asp Gln Lys Asp Thr Asp Gly Asp 
545                 550                 555                 560 


Gly Arg Gly Asp Ala Cys Asp Asp Asp Met Asp Gly Asp Gly Ile Lys 
                565                 570                 575     


Asn Ile Leu Asp Asn Cys Pro Lys Phe Pro Asn Arg Asp Gln Arg Asp 
            580                 585                 590         


Lys Asp Gly Asp Gly Val Gly Asp Ala Cys Asp Ser Cys Pro Asp Val 
        595                 600                 605             


Ser Asn Pro Asn Gln Ser Asp Val Asp Asn Asp Leu Val Gly Asp Ser 
    610                 615                 620                 


Cys Asp Thr Asn Gln Asp Ser Asp Gly Asp Gly His Gln Asp Ser Thr 
625                 630                 635                 640 


Asp Asn Cys Pro Thr Val Ile Asn Ser Ala Gln Leu Asp Thr Asp Lys 
                645                 650                 655     


Asp Gly Ile Gly Asp Glu Cys Asp Asp Asp Asp Asp Asn Asp Gly Ile 
            660                 665                 670         


Pro Asp Leu Val Pro Pro Gly Pro Asp Asn Cys Arg Leu Val Pro Asn 
        675                 680                 685             


Pro Ala Gln Glu Asp Ser Asn Ser Asp Gly Val Gly Asp Ile Cys Glu 
    690                 695                 700                 


Ser Asp Phe Asp Gln Asp Gln Val Ile Asp Arg Ile Asp Val Cys Pro 
705                 710                 715                 720 


Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg Ala Tyr Gln Thr Val 
                725                 730                 735     


Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val Val 
            740                 745                 750         


Leu Asn Gln Gly Met Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly 
        755                 760                 765             


Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly Thr 
    770                 775                 780                 


Phe His Val Asn Thr Gln Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe 
785                 790                 795                 800 


Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val Met Trp Lys Gln Thr 
                805                 810                 815     


Glu Gln Thr Tyr Trp Gln Ala Thr Pro Phe Arg Ala Val Ala Glu Pro 
            820                 825                 830         


Gly Ile Gln Leu Lys Ala Val Lys Ser Lys Thr Gly Pro Gly Glu His 
        835                 840                 845             


Leu Arg Asn Ser Leu Trp His Thr Gly Asp Thr Ser Asp Gln Val Arg 
    850                 855                 860                 


Leu Leu Trp Lys Asp Ser Arg Asn Val Gly Trp Lys Asp Lys Val Ser 
865                 870                 875                 880 


Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val Gly Tyr Ile Arg Val 
                885                 890                 895     


Arg Phe Tyr Glu Gly Ser Glu Leu Val Ala Asp Ser Gly Val Thr Ile 
            900                 905                 910         


Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe Ser Gln 
        915                 920                 925             


Glu Asn Ile Ile Trp Ser Asn Leu Lys Tyr Arg Cys Asn Asp Thr Ile 
    930                 935                 940                 


Pro Glu Asp Phe Gln Glu Phe Gln Thr Gln Asn Phe Asp Arg Phe Asp 
945                 950                 955                 960 


Asn 
    


<210>  1047
<211>  1907
<212>  DNA
<213>  Homosapiens

<400>  1047
ggctccgccg aggctgatct tcgttcaagt gtgagctgcg gctgagccca gcgctcgagg     60

cgcgaggcag ccaggagggc ccgtgcggcg cggggagcca gcgagcgcgc cttcggcatt    120

ggccgccgcg atgtcagctc agtgctgtgc gggccagctg gcctgctgct gtgggtctgc    180

aggctgctct ctctgctgtg attgctgccc caggattcgg cagtccctca gcacccgctt    240

catgtacgcc ctctacttca ttctggtcgt cgtcctctgc tgcatcatga tgtcaacaac    300

cgtggctcac aagatgaaag agcacattcc tttttttgaa gatatgtgta aaggcattaa    360

agctggtgac acctgtgaga agctggtggg atattctgcc gtgtatagag tctgttttgg    420

aatggcttgt ttcttcttta tcttctgtct actgaccttg aaaatcaaca acagcaaaag    480

ttgtagagct catattcaca atggcttttg gttctttaaa cttctgctgt tgggggccat    540

gtgctcagga gctttcttca ttccagatca ggacaccttt ctgaacgcct ggcgctatgt    600

gggagccgtc ggaggcttcc tcttcattgg catccagctc ctcctgctcg tggagtttgc    660

acataagtgg aacaagaact ggacagcagg cacagccagt aacaagctgt ggtacgcctc    720

cctggccctg gtgacgctca tcatgtattc cattgccact ggaggcttgg ttttgatggc    780

agtgttttat acacagaaag acagctgcat ggaaaacaaa attctgctgg gagtaaatgg    840

aggcctgtgc ctgcttatat cattggtagc catctcaccc tgggtccaaa atcgacagcc    900

acactcgggg ctcttacaat caggggtcat aagctgctat gtcacctacc tcaccttctc    960

agctctgtcc agcaaacctg cagaagtagt tctagatgaa catgggaaaa atgttacaat   1020

ctgtgtgcct gactttggtc aagacctgta cagagatgaa aacttggtga ctatactggg   1080

gaccagcctc ttaatcggat gtatcttgta ttcatgtttg acatcaacaa caagatcgag   1140

ttctgacgct ctgcaggggc gatacgcagc tcctgaattg gagatagctc gctgttgttt   1200

ttgcttcagt cctggtggag aggacactga agagcagcag ccggggaagg agggaccacg   1260

ggtcatttat gacgagaaga aaggcaccgt ctacatctac tcctacttcc acttcgtgtt   1320

cttcctagct tccctgtatg tgatgatgac cgtcaccaac tggttcaacc atgtaagaag   1380

tgcctttcac ctcctgccat gattctgagg cctccccagc catgtggaac tctgagaaac   1440

ctgaacggac tccatttggc tccttcattt gcaagacatc aagggctcct tacccacccc   1500

cttcctcaag gaattaactt gtgcaagctg actcccagca catcaaagaa tgcaattaac   1560

tgataacatg ctgtggcaag ctatgtccgc agttcccagg aatttgtcca gttgatatta   1620

ccctaagccc ctgtgttttt gtctggttga tagcacccaa agcccagcgt ctatcacctt   1680

gtgatggatt taaagcccct gcacctggaa ctgtttgctt tcctgtaacc atttgtcttt   1740

ttaacttctt ttgcctgttt tacttctgta agactgctac agctaggctc cccctcccct   1800

ctttaaacca aagtataaaa caaaatctag ccccttcttc agggccgaga gaattttgag   1860

cactagccgt ctctcggtcg ctggctaata aaggactcct caattcg                 1907


<210>  1048
<211>  423
<212>  PRT
<213>  Homosapiens

<400>  1048

Met Ser Ala Gln Cys Cys Ala Gly Gln Leu Ala Cys Cys Cys Gly Ser 
1               5                   10                  15      


Ala Gly Cys Ser Leu Cys Cys Asp Cys Cys Pro Arg Ile Arg Gln Ser 
            20                  25                  30          


Leu Ser Thr Arg Phe Met Tyr Ala Leu Tyr Phe Ile Leu Val Val Val 
        35                  40                  45              


Leu Cys Cys Ile Met Met Ser Thr Thr Val Ala His Lys Met Lys Glu 
    50                  55                  60                  


His Ile Pro Phe Phe Glu Asp Met Cys Lys Gly Ile Lys Ala Gly Asp 
65                  70                  75                  80  


Thr Cys Glu Lys Leu Val Gly Tyr Ser Ala Val Tyr Arg Val Cys Phe 
                85                  90                  95      


Gly Met Ala Cys Phe Phe Phe Ile Phe Cys Leu Leu Thr Leu Lys Ile 
            100                 105                 110         


Asn Asn Ser Lys Ser Cys Arg Ala His Ile His Asn Gly Phe Trp Phe 
        115                 120                 125             


Phe Lys Leu Leu Leu Leu Gly Ala Met Cys Ser Gly Ala Phe Phe Ile 
    130                 135                 140                 


Pro Asp Gln Asp Thr Phe Leu Asn Ala Trp Arg Tyr Val Gly Ala Val 
145                 150                 155                 160 


Gly Gly Phe Leu Phe Ile Gly Ile Gln Leu Leu Leu Leu Val Glu Phe 
                165                 170                 175     


Ala His Lys Trp Asn Lys Asn Trp Thr Ala Gly Thr Ala Ser Asn Lys 
            180                 185                 190         


Leu Trp Tyr Ala Ser Leu Ala Leu Val Thr Leu Ile Met Tyr Ser Ile 
        195                 200                 205             


Ala Thr Gly Gly Leu Val Leu Met Ala Val Phe Tyr Thr Gln Lys Asp 
    210                 215                 220                 


Ser Cys Met Glu Asn Lys Ile Leu Leu Gly Val Asn Gly Gly Leu Cys 
225                 230                 235                 240 


Leu Leu Ile Ser Leu Val Ala Ile Ser Pro Trp Val Gln Asn Arg Gln 
                245                 250                 255     


Pro His Ser Gly Leu Leu Gln Ser Gly Val Ile Ser Cys Tyr Val Thr 
            260                 265                 270         


Tyr Leu Thr Phe Ser Ala Leu Ser Ser Lys Pro Ala Glu Val Val Leu 
        275                 280                 285             


Asp Glu His Gly Lys Asn Val Thr Ile Cys Val Pro Asp Phe Gly Gln 
    290                 295                 300                 


Asp Leu Tyr Arg Asp Glu Asn Leu Val Thr Ile Leu Gly Thr Ser Leu 
305                 310                 315                 320 


Leu Ile Gly Cys Ile Leu Tyr Ser Cys Leu Thr Ser Thr Thr Arg Ser 
                325                 330                 335     


Ser Ser Asp Ala Leu Gln Gly Arg Tyr Ala Ala Pro Glu Leu Glu Ile 
            340                 345                 350         


Ala Arg Cys Cys Phe Cys Phe Ser Pro Gly Gly Glu Asp Thr Glu Glu 
        355                 360                 365             


Gln Gln Pro Gly Lys Glu Gly Pro Arg Val Ile Tyr Asp Glu Lys Lys 
    370                 375                 380                 


Gly Thr Val Tyr Ile Tyr Ser Tyr Phe His Phe Val Phe Phe Leu Ala 
385                 390                 395                 400 


Ser Leu Tyr Val Met Met Thr Val Thr Asn Trp Phe Asn His Val Arg 
                405                 410                 415     


Ser Ala Phe His Leu Leu Pro 
            420             


<210>  1049
<211>  1880
<212>  DNA
<213>  Homosapiens

<400>  1049
ctttcccacc cttcctcccc acaaggctgt ctgagatgcc accttccacc taaacatcat     60

ctcccaaatt ttaatcctta actttggtct ctgacttctg cttgattcca cagtctccac    120

ccacatttgc acaaaggacc atcacctgtc cttcctggaa tctctaaagt tttctgcttt    180

ccttctgtcc tgatggccag ctctgctaag tcagctgaga tgcccaccat ctccaaaacc    240

cttaacccta ctcctgatcc tcatcaagaa tatctggacc ctaggattac cattgcctta    300

ttcgaaattg gatcacattc cccttcctcc tggggctctc tccctttcct aaagaatagc    360

agccatcaag ttacagaaca acagactgca cagaagttta acaatctctt aaaagaaatt    420

aaagatattc ttaaaaatat ggcaggtttt gaagagaaga tcacagaagc aaaagaactt    480

tttgaggaaa ccaatattac tgaggatgtg tcagcccaca aagaaaatat cagaggactt    540

gacaaaatca atgaaatgtt atcaacaaac ctgcctgtta gtttagcccc agagaaagaa    600

gacaatgaaa agaaacagga gatgatattg gaaaccaata ttactgagga tgtgtcagcc    660

cacaaagaaa atatcagagg acttgacaaa atcaatgaaa tgttatcaac aaacctgcct    720

gttagtttag ccccagagaa agaagacaat gaaaagaaac agcagatgat aatggaaaac    780

cagaactctg agaacaccgc acaagttttt gcaagagatt tggtaaatcg tttagaagaa    840

aaaaaagtcc ttaacgaaac tcaacaaagt caggaaaaag caaaaaacag acttaatgtt    900

caagaagaaa ctatgaaaat taggaacaac atggagcagt tactacagga agcagaacac    960

tggagtaaac aacatactga gctcagtaaa ctgataaaat cctatcagaa atctcagaaa   1020

gacataagtg aaactcttgg aaataatgga gtcggtttcc aaacccagcc aaataatgaa   1080

gtgtcggcta agcatgagct ggaggaacag gtgaagaaac tgagccatga cacctattca   1140

ttgcagttga tggcagcttt gctagagaat gaatgccaaa tcttacagca gagagtagag   1200

attctcaagg aactccatca tcagaaacag ggaactctgc aagagaagcc aattcagata   1260

aactataaac aggacaagaa aaatcagaag ccatcagaag caaagaaagt agaaatgtat   1320

aagcagaaca agcaagcaat gaagggtaca ttttggaaaa aagacagatc ctgtagaagc   1380

ctggatgttt gtcttaataa gaaagcttgc aatacccagt tcaatattca tgttgcaaga   1440

aaagctctta ggggaaaaat gaggtcagct agcagcctaa gatagaaaat accaaaagca   1500

gatgaaaagg tgaatcctta aaaaactaca tctgttacct ccaacttgtc agtcatgatc   1560

aatcatcaaa ccttgggcag atctgctggt tcaaccaaga aagagctata gaataaggag   1620

attgacactt atattactca ttacttcagc agttatgtaa gtctggtctt taatgaccat   1680

tgtgtctaca tcaagttcat aacttttcac ctttacaatc tgcttgtttt ttttgtaatt   1740

attagataga cagcctagag tgagaagtta aaggtccaat taagttaaga tctaaataaa   1800

aaccagaata caagggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1860

aaaaaaaaaa aaaaaaaaaa                                               1880


<210>  1050
<211>  430
<212>  PRT
<213>  Homosapiens

<400>  1050

Met Ala Ser Ser Ala Lys Ser Ala Glu Met Pro Thr Ile Ser Lys Thr 
1               5                   10                  15      


Leu Asn Pro Thr Pro Asp Pro His Gln Glu Tyr Leu Asp Pro Arg Ile 
            20                  25                  30          


Thr Ile Ala Leu Phe Glu Ile Gly Ser His Ser Pro Ser Ser Trp Gly 
        35                  40                  45              


Ser Leu Pro Phe Leu Lys Asn Ser Ser His Gln Val Thr Glu Gln Gln 
    50                  55                  60                  


Thr Ala Gln Lys Phe Asn Asn Leu Leu Lys Glu Ile Lys Asp Ile Leu 
65                  70                  75                  80  


Lys Asn Met Ala Gly Phe Glu Glu Lys Ile Thr Glu Ala Lys Glu Leu 
                85                  90                  95      


Phe Glu Glu Thr Asn Ile Thr Glu Asp Val Ser Ala His Lys Glu Asn 
            100                 105                 110         


Ile Arg Gly Leu Asp Lys Ile Asn Glu Met Leu Ser Thr Asn Leu Pro 
        115                 120                 125             


Val Ser Leu Ala Pro Glu Lys Glu Asp Asn Glu Lys Lys Gln Glu Met 
    130                 135                 140                 


Ile Leu Glu Thr Asn Ile Thr Glu Asp Val Ser Ala His Lys Glu Asn 
145                 150                 155                 160 


Ile Arg Gly Leu Asp Lys Ile Asn Glu Met Leu Ser Thr Asn Leu Pro 
                165                 170                 175     


Val Ser Leu Ala Pro Glu Lys Glu Asp Asn Glu Lys Lys Gln Gln Met 
            180                 185                 190         


Ile Met Glu Asn Gln Asn Ser Glu Asn Thr Ala Gln Val Phe Ala Arg 
        195                 200                 205             


Asp Leu Val Asn Arg Leu Glu Glu Lys Lys Val Leu Asn Glu Thr Gln 
    210                 215                 220                 


Gln Ser Gln Glu Lys Ala Lys Asn Arg Leu Asn Val Gln Glu Glu Thr 
225                 230                 235                 240 


Met Lys Ile Arg Asn Asn Met Glu Gln Leu Leu Gln Glu Ala Glu His 
                245                 250                 255     


Trp Ser Lys Gln His Thr Glu Leu Ser Lys Leu Ile Lys Ser Tyr Gln 
            260                 265                 270         


Lys Ser Gln Lys Asp Ile Ser Glu Thr Leu Gly Asn Asn Gly Val Gly 
        275                 280                 285             


Phe Gln Thr Gln Pro Asn Asn Glu Val Ser Ala Lys His Glu Leu Glu 
    290                 295                 300                 


Glu Gln Val Lys Lys Leu Ser His Asp Thr Tyr Ser Leu Gln Leu Met 
305                 310                 315                 320 


Ala Ala Leu Leu Glu Asn Glu Cys Gln Ile Leu Gln Gln Arg Val Glu 
                325                 330                 335     


Ile Leu Lys Glu Leu His His Gln Lys Gln Gly Thr Leu Gln Glu Lys 
            340                 345                 350         


Pro Ile Gln Ile Asn Tyr Lys Gln Asp Lys Lys Asn Gln Lys Pro Ser 
        355                 360                 365             


Glu Ala Lys Lys Val Glu Met Tyr Lys Gln Asn Lys Gln Ala Met Lys 
    370                 375                 380                 


Gly Thr Phe Trp Lys Lys Asp Arg Ser Cys Arg Ser Leu Asp Val Cys 
385                 390                 395                 400 


Leu Asn Lys Lys Ala Cys Asn Thr Gln Phe Asn Ile His Val Ala Arg 
                405                 410                 415     


Lys Ala Leu Arg Gly Lys Met Arg Ser Ala Ser Ser Leu Arg 
            420                 425                 430 


<210>  1051
<211>  1362
<212>  DNA
<213>  Homosapiens

<400>  1051
gcggcggcaa catggcggac gtgataaatg tcagtgtgaa cctggaggcc ttttcccagg     60

ccattagtgc catccaggcg ctgcgctcca gcgtgagcag gttgttcgac tgcctgaagg    120

atgggatgcg gaacaaggag acgctggagg gccgggagaa ggccttcatt gcgcacttcc    180

aggacaactt acattcggtc aaccgggacc tcaatgagct ggaacgtctg agcaatctgg    240

taggcaagcc atctgagaac catcctcttc ataacagtgg gctgttaagc ctggatcctg    300

tgcaggacaa aactcctctc tatagtcaac tccttcaagc atataagtgg tcaaacaagt    360

tgcagtacca tgcaggacta gcatctggcc ttttaaatca gtagtcgttg aagcgttccg    420

ctaatcagat gggagtatct gccaaaagta gaccaaaggc tcagcccaca actcttgtcc    480

taccacctca atatgttgat gatgtgatca gccgcattga caggatgttt cctgaaatgt    540

ccatccactt atccagaccc aatggaacat cagcaatgct tctggtgacc ttgggaaagg    600

tgttgaaagt gatcgtcatc atgcggagcc tgttcattga tcgaacaata gtaaagggat    660

ataacgagaa tgtctacaca gaagatggca agcttgatat atggtccaaa tccaactatc    720

aagtattcca gaaggtgaca gaccacgcca ccacggccct gctccactat cagctgcccc    780

agatgccgga tgtcgtagtc cgatccttca tgacctggtt aagaagttac ataaagctgt    840

tccaggcccc atgccagcac tgcgggaagt ttctgcagga cggccttccc ccgacatgga    900

gggatttccg aaccctcgaa gccttccatg acacctgccg gcagtaagcc cccacgctgg    960

ccccagcgtg agaccccacc cggcaacttc ccagacactc aggaagccca cagaaggctc   1020

agctggttcc tcactgccca gatgtgtaca gccgctcctc cctttcagcg ccatgtgtgc   1080

tgaggccact cttgaggagc agaccccccc tgtggctgat gagactaatt attcccacta   1140

gccagtggac tgaaggcaaa gaagactttt ctagaacctg atagaaggaa gctgtgcagc   1200

atgctcctcg tccgtgtgtg tcggcagtgc tggtgtcttg tcgtttccgc gagctattac   1260

tagaatgagc ccttgtgttc atgggtatcg tcatgcgggg ttcttgtgtt ttgtggggct   1320

tggggtttgg taacttattt ttataagcaa taaacctttt gt                      1362


<210>  1052
<211>  311
<212>  PRT
<213>  Homosapiens


<220>
<221>  misc_feature
<222>  (131)..(131)
<223>  Xaa can be any naturally occurring amino acid

<400>  1052

Met Ala Asp Val Ile Asn Val Ser Val Asn Leu Glu Ala Phe Ser Gln 
1               5                   10                  15      


Ala Ile Ser Ala Ile Gln Ala Leu Arg Ser Ser Val Ser Arg Leu Phe 
            20                  25                  30          


Asp Cys Leu Lys Asp Gly Met Arg Asn Lys Glu Thr Leu Glu Gly Arg 
        35                  40                  45              


Glu Lys Ala Phe Ile Ala His Phe Gln Asp Asn Leu His Ser Val Asn 
    50                  55                  60                  


Arg Asp Leu Asn Glu Leu Glu Arg Leu Ser Asn Leu Val Gly Lys Pro 
65                  70                  75                  80  


Ser Glu Asn His Pro Leu His Asn Ser Gly Leu Leu Ser Leu Asp Pro 
                85                  90                  95      


Val Gln Asp Lys Thr Pro Leu Tyr Ser Gln Leu Leu Gln Ala Tyr Lys 
            100                 105                 110         


Trp Ser Asn Lys Leu Gln Tyr His Ala Gly Leu Ala Ser Gly Leu Leu 
        115                 120                 125             


Asn Gln Xaa Ser Leu Lys Arg Ser Ala Asn Gln Met Gly Val Ser Ala 
    130                 135                 140                 


Lys Ser Arg Pro Lys Ala Gln Pro Thr Thr Leu Val Leu Pro Pro Gln 
145                 150                 155                 160 


Tyr Val Asp Asp Val Ile Ser Arg Ile Asp Arg Met Phe Pro Glu Met 
                165                 170                 175     


Ser Ile His Leu Ser Arg Pro Asn Gly Thr Ser Ala Met Leu Leu Val 
            180                 185                 190         


Thr Leu Gly Lys Val Leu Lys Val Ile Val Ile Met Arg Ser Leu Phe 
        195                 200                 205             


Ile Asp Arg Thr Ile Val Lys Gly Tyr Asn Glu Asn Val Tyr Thr Glu 
    210                 215                 220                 


Asp Gly Lys Leu Asp Ile Trp Ser Lys Ser Asn Tyr Gln Val Phe Gln 
225                 230                 235                 240 


Lys Val Thr Asp His Ala Thr Thr Ala Leu Leu His Tyr Gln Leu Pro 
                245                 250                 255     


Gln Met Pro Asp Val Val Val Arg Ser Phe Met Thr Trp Leu Arg Ser 
            260                 265                 270         


Tyr Ile Lys Leu Phe Gln Ala Pro Cys Gln His Cys Gly Lys Phe Leu 
        275                 280                 285             


Gln Asp Gly Leu Pro Pro Thr Trp Arg Asp Phe Arg Thr Leu Glu Ala 
    290                 295                 300                 


Phe His Asp Thr Cys Arg Gln 
305                 310     


<210>  1053
<211>  852
<212>  DNA
<213>  Homosapiens

<400>  1053
gcggcggcaa catggcggac gtgataaatg tcagtgtgaa cctggaggcc ttttcccagg     60

ccattagtgc catccaggcg ctgcgctcca gcgtgagcag gttgttcgac tgcctgaagg    120

atgggatgcg gaacaaggag acgctggagg gccgggagaa ggccttcatt gcgcacttcc    180

aggacaactt acattcggtc aaccgggacc tcaatgagct ggaacgtctg agcaatctgg    240

taggcaagcc atctgagaac catcctcttc ataacagtgg gctgttaagc ctggatcctg    300

tgcaggacaa aactcctctc tatagtcaac tccttcaagc atataagtgg tcaaacaagt    360

tgcagtacca tgcaggacta gcatctggcc ttttaaatca gtagtcgttg aagcgttccg    420

ctaatcagat gggagtatct gccaaaagta gaccaaaggc tcagcccaca actcttgtcc    480

taccacctca atatgttgat gatgtgatca gccgcattga caggatgttt cctgaaatgt    540

ccatccactt atccagaccc aatggaacat cagcaatgct tctgcttgat atatggtcca    600

aatccaacta tcaagtattc cagaaggtga cagaccacgc caccacggcc ctgctccact    660

atcagctgcc ccagatgccg gatgtcgtag tccgatcctt catgacctgg ttaagaagtt    720

acataaagct gttccaggcc ccatgccagc actgcgggaa gtttctgcag gacggccttc    780

ccccgacatg gagggatttc cgaaccctcg aagccttcca tgacacctgc cggcagtaag    840

cccccacgct gg                                                        852


<210>  1054
<211>  275
<212>  PRT
<213>  Homosapiens


<220>
<221>  misc_feature
<222>  (131)..(131)
<223>  Xaa can be any naturally occurring amino acid

<400>  1054

Met Ala Asp Val Ile Asn Val Ser Val Asn Leu Glu Ala Phe Ser Gln 
1               5                   10                  15      


Ala Ile Ser Ala Ile Gln Ala Leu Arg Ser Ser Val Ser Arg Leu Phe 
            20                  25                  30          


Asp Cys Leu Lys Asp Gly Met Arg Asn Lys Glu Thr Leu Glu Gly Arg 
        35                  40                  45              


Glu Lys Ala Phe Ile Ala His Phe Gln Asp Asn Leu His Ser Val Asn 
    50                  55                  60                  


Arg Asp Leu Asn Glu Leu Glu Arg Leu Ser Asn Leu Val Gly Lys Pro 
65                  70                  75                  80  


Ser Glu Asn His Pro Leu His Asn Ser Gly Leu Leu Ser Leu Asp Pro 
                85                  90                  95      


Val Gln Asp Lys Thr Pro Leu Tyr Ser Gln Leu Leu Gln Ala Tyr Lys 
            100                 105                 110         


Trp Ser Asn Lys Leu Gln Tyr His Ala Gly Leu Ala Ser Gly Leu Leu 
        115                 120                 125             


Asn Gln Xaa Ser Leu Lys Arg Ser Ala Asn Gln Met Gly Val Ser Ala 
    130                 135                 140                 


Lys Ser Arg Pro Lys Ala Gln Pro Thr Thr Leu Val Leu Pro Pro Gln 
145                 150                 155                 160 


Tyr Val Asp Asp Val Ile Ser Arg Ile Asp Arg Met Phe Pro Glu Met 
                165                 170                 175     


Ser Ile His Leu Ser Arg Pro Asn Gly Thr Ser Ala Met Leu Leu Leu 
            180                 185                 190         


Asp Ile Trp Ser Lys Ser Asn Tyr Gln Val Phe Gln Lys Val Thr Asp 
        195                 200                 205             


His Ala Thr Thr Ala Leu Leu His Tyr Gln Leu Pro Gln Met Pro Asp 
    210                 215                 220                 


Val Val Val Arg Ser Phe Met Thr Trp Leu Arg Ser Tyr Ile Lys Leu 
225                 230                 235                 240 


Phe Gln Ala Pro Cys Gln His Cys Gly Lys Phe Leu Gln Asp Gly Leu 
                245                 250                 255     


Pro Pro Thr Trp Arg Asp Phe Arg Thr Leu Glu Ala Phe His Asp Thr 
            260                 265                 270         


Cys Arg Gln 
        275 


<210>  1055
<211>  6280
<212>  DNA
<213>  Homosapiens

<400>  1055
gggactccca ggactcccgg ccggggtagc tcttcactcc tcagcgcgac gtcgtgtcga     60

gttcccaaaa agctccgcag gggctgtagg gaggcataca agaattaaat tctgaataag    120

tctgcaggta ggatggacag ttattttaaa gcagctgtca gtgacttgga caaactcctt    180

gatgattttg aacagaaccc agatgaacaa gattatctcc aagatgtaca aaatgcatat    240

gattctaacc actgctcagt ttcttcagag ttggcttcct cacagcgaac ttcattgctc    300

ccaaaagacc aagagtgcgt taatagttgt gcctcatcag aaacaagcta tggaacaaat    360

gagagttccc tgaatgaaaa aacactcaag ggacttactt ctatacaaaa tgaaaaaaat    420

gtaacaggac ttgatcttct ttcttctgtg gatggtggta cttcagatga aatccagccg    480

ttatatatgg gacgatgtag taaacctatc tgtgatctga taagtgacat gggtaactta    540

gttcatgcaa ccaatagtga agaagatatt aaaaaattat tgccagatga ttttaagtct    600

aatgcagatt ccttgattgg attggattta tcttcagtgt cagatactcc ctgtgtttct    660

tcaacagacc atgatagtga tactgtcaga gaacaacaga atgataccag ttctgaatta    720

caaaatagag aaatcggagg aatcaaagaa ttgggtataa aagtagatac aacactttca    780

gattcctata attacagtgg aacagaaaat ttaaaagata aaaagatctt taatcagtta    840

gaatcaattg ttgattttaa catgtcatct gctttgactc gacaaagttc caaaatgttt    900

catgccaaag acaagctaca acacaagagc cagccatgtg gattactaaa agatgttggc    960

ttagtaaaag aggaagtaga tgtggcagtc ataactgccg cagaatgttt aaaagaagag   1020

ggcaagacaa gtgctttgac ctgcagcctt ccgaaaaatg aagatttatg cttaaatgat   1080

tcaaattcaa gagatgaaaa tttcaaatta cctgactttt cctttcagga agataagact   1140

gttataaaac aatctgcaca agaagactca aaaagtttag accttaagga taatgatgta   1200

atccaagatt cctcttcagc tttacatgtt tccagtaaag atgtgccgtc ctcattgtcc   1260

tgtcttcctg cgtctgggtc tatgagtgga tcattaattg aaagtaaagc acggggtgat   1320

tttttacctc agcatgaaca taaagataat atacaagatg cagtgactat acatgaagaa   1380

atacagaaca gtgttgttct aggtggggaa ccattcaaag agaatgatct tttgaaacag   1440

gaaaaatgta aaagcatact ccttcagtca ttaattgaag ggatggaaga cagaaagata   1500

gatcctgacc agacagtaat cagagctgag tctttggatg gtggtgacac cagttctaca   1560

gttgtagaat ctcaagaggg gctttctggc actcatgtcc cagagtcttc tgattgttgt   1620

gaaggtttta ttaatacttt ttcaagcaat gatatggatg ggcaagactt agattacttt   1680

aatattgatg aaggcgcaaa aagtggccca ctaattagtg atgctgaact tgatgccttt   1740

ctgacagaac agtatcttca gaccactaac ataaagtctt ttgaagaaaa tgtaaatgac   1800

tctaaatcgc aaatgaatca gatagatatg aaaggcttag atgatggaaa catcaataat   1860

atatatttca atgcagaagc aggagctatt ggggaaagtc atggtattaa tataatttgt   1920

gaaacagttg ataaacaaaa tacaatagaa aatggccttt ctttaggaga aaaaagcact   1980

attccagttc aacaagggtt acctaccagt aagtctgaga ttacaaatca attatcagtc   2040

tctgatatta acagtcaatc tgttggaggg gccagaccta agcaattgtt tagccttcca   2100

tcaagaacaa ggagttcaaa ggacctgaat aagccagatg ttccagatac aatagaaagt   2160

gaacccagca cagcagatac cgttgttcca atcacttgtg ctatagattc tacagctgat   2220

ccacaggtta gcttcaactc taattacatt gatatagaaa gtaattctga aggtggatct   2280

agtttcgtaa ctgcaaatga agattctgta cctgaaaaca cttgcaaaga aggcttggtt   2340

ttgggccaga aacagcctac ttgggttcct gattcagaag ctccaaactg tatgaactgc   2400

caagtcaaat ttacttttac caaacggcga caccattgcc gagcatgtgg gaaagtattt   2460

tgtggtgtct gttgtaatag gaagtgtaaa ctgcaatatc tagaaaagga agcaagagta   2520

tgtgtagtct gctatgaaac tattagtaaa gctcaggcat ttgaaaggat gatgagtcca   2580

actggttcta atcttaagtc taatcattct gatgaatgta ctactgtcca gcctcctcag   2640

gagaaccaaa catccagtat accttcacca gcaactttgc cagtctcagc acttaaacaa   2700

ccaggtgttg aaggactatg ttccaaagaa cagaagagag tatggtttgc agatggtata   2760

ttgcccaatg gtgaagttgc agatacaaca aaattatcat ctggaagtaa aagatgttct   2820

gaagacttta gtcctctctc acctgatgtg cctatgacag taaacacagt ggatcattcc   2880

cattctacta cagtggaaaa gccaaacaat gagacaggag atattacaag aaatgagata   2940

attcagagtc ctatttctca ggttccatca gtggaaaaat tgtctatgaa cacaggaaat   3000

gaggggttac ctacttctgg ttcatttaca ctagatgatg atgtttttgc agaaactgaa   3060

gaaccatcta gtcctactgg tgtcttagtt aacagcaatt tacctattgc tagtatttca   3120

gattataggt tactgtgtga tattaacaag tatgtctgca ataagattag tcttctacct   3180

aatgatgagg acagtttgcc cccacttctg gttgcatctg gagaaaaggg atcagtgcct   3240

gtagtagaag aacatccatc tcatgagcag atcattttgc ttcttgaagg tgaaggcttt   3300

catcctgtta catttgtcct aaatgctaat ctactcgtga atgtcaaatt catattttat   3360

tcctcagaca aatattggta cttttcaacc aatggattgc atggcttggg acaggcagaa   3420

attattattc tattgttatg tttgccaaat gaagatacta ttcctaagga catcttcaga   3480

ctatttatca ccatatataa ggatgctcta aaaggaaaat acatagaaaa cttggacaat   3540

attaccttta ctgagagttt tctcagtagc aaggatcacg gaggattcct gtttattaca   3600

cctacttttc agaaacttga tgatctctca ttaccaagta atccttttct ttgtggaatt   3660

cttatccaga agcttgagat tccctgggca aaggtttttc ctatgcgttt aatgttgaga   3720

ttgggtgcag aatataaagc atatcctgct cctctaacaa gcatcagagg ccgaaaacct   3780

ctttttggag aaataggaca cactattatg aacttacttg ttgaccttcg aaattaccag   3840

tataccttgc ataatataga tcaactgttg attcatatgg aaatgggaaa aagctgcata   3900

aaaataccac ggaaaaagta cagtgatgta atgaaagtac taaattcttc caatgagcat   3960

gtcattagca ttggagcaag tttcagtaca gaagcagatt ctcatctagt ctgtatacag   4020

aatgatggaa tttatgaaac acaggccaac agtaccactg gccatcctag aaaagtgaca   4080

ggtgcaagtt ttgtggtatt caatggagct ctaaaaacat cttcaggatt tcttgctaag   4140

tccagcatag ttgaagatgg cttaatggta caaataactc cagagaccat gaatggcttg   4200

cggctagctt tacgagaaca gaaagacttt aaaattacat gtgggaaagt tgatgcagta   4260

gacctgagag aatacgtgga tatctgctgg gtagatgctg aagaaaaagg aaacaaagga   4320

gttatcagtt cagtggatgg aatatcatta caaggatttc caagtgaaaa aataaaactg   4380

gaagcagatt ttgaaaccga tgagaagatt gtaaaatgta ccgaggtgtt ctactttcta   4440

aaggaccagg atttatctat tttatcaact tcttatcagt ttgcaaaaga aatagccatg   4500

gcttgtagtg ctgcgctgtg ccctcacctg aaaactctaa aaagtaatgg gatgaataaa   4560

attggactca gagtttccat tgacactgat atggttgaat ttcaggcagg atctgaaggc   4620

caacttctgc ctcagcatta tctaaatgat cttgatagtg ctctgatacc tgtgatccat   4680

ggtgggacct ccaactctag tttaccatta gaaatagaat tagtgttttt cattatagaa   4740

catctttttt agtgaaagaa tgtgccatat tacatattgc aacctaattt gttaaaacta   4800

actccagcac taaagctgaa atgccacaaa cactaaaagt ataaatatgt ctgatttttg   4860

aaacacataa gctttgctct ttaggcagga atgatctttt caaatcatta gcacaatatt   4920

taaatatcta aaaatttaag agatccatac tttctgtagc tttacaatta atttaagtac   4980

taaaaagaca aggatttctt ttaagaaatt tatagcattt actgtgttat ttaaatgcta   5040

agccaaagta tctgcactta ggtatacctc tttatgccaa taatgatttt aatgaaggct   5100

cttttcagat gtaaccttat gaaggaaata tctgctttgt gtatatgcca gttagaatac   5160

tggtttctaa agtctgtcaa attgtatttc agtggcacaa aaaccagttt tgaggtctta   5220

gacttataat tctttgaata aaactgataa cttatttgta taattggagt ggagacctac   5280

ctccataatt agataaactc tttttggatt ataatcagaa ttttgccttt tttcttctca   5340

aattattaca tatgtatgta ttatatatcc acatatatag ttttccctga ttaaatggat   5400

attaaaataa ttgcgggtgc ttcaggactt tttgcttcta tatttaagta tattgttttt   5460

atagcaagaa catattctga atgttttata aatctttaat aatttatatg taggtaatat   5520

ttttgtatca caatgcatta tttttttcct cctttccttc caaactatac cactgtattt   5580

accacttcta agagtgactg acgacgggcc agatgaccct tgaagtagtc attatgtagc   5640

aataaatgaa gcctgaaaca ggttttttta cttccacttt aatccttaga aatttcttgg   5700

caacttcgca tattttcatt gacaccggtg tataagtata aatttaaatg aactaattac   5760

ttttgcatat tttaaattct ttatatggta gttatttttt ataacaggat attaacataa   5820

gttaaatcct atgtatttga aattgttaca gagctttcct ctttacttca aacagcaaaa   5880

aagtgggggg catattgtag tcctgtcatt taagttatgt aaaaaattta atcattattt   5940

tgatgcttta aacattctca tgtgtaatat atgtttttgt atcaaaaaca ctcatatatt   6000

tcaagaaaaa gaaattatgt taaatagccc tgttttaaga aaaatattta tgaagcatct   6060

caacttgaag atcaagtcaa agttataact caggatctga ggtctcaagc taggagagac   6120

tgagaatttt aatcagtttg ggcatatagt ttggactgaa tcacatctgt agtacttagc   6180

caaagacaat ttggaggaga atatcagcct tctggaagta gctacttcct gaacaatgta   6240

aagtgtcgca gatattcaat aaaatggcaa cctgttaaaa                         6280


<210>  1056
<211>  1539
<212>  PRT
<213>  Homosapiens

<400>  1056

Met Asp Ser Tyr Phe Lys Ala Ala Val Ser Asp Leu Asp Lys Leu Leu 
1               5                   10                  15      


Asp Asp Phe Glu Gln Asn Pro Asp Glu Gln Asp Tyr Leu Gln Asp Val 
            20                  25                  30          


Gln Asn Ala Tyr Asp Ser Asn His Cys Ser Val Ser Ser Glu Leu Ala 
        35                  40                  45              


Ser Ser Gln Arg Thr Ser Leu Leu Pro Lys Asp Gln Glu Cys Val Asn 
    50                  55                  60                  


Ser Cys Ala Ser Ser Glu Thr Ser Tyr Gly Thr Asn Glu Ser Ser Leu 
65                  70                  75                  80  


Asn Glu Lys Thr Leu Lys Gly Leu Thr Ser Ile Gln Asn Glu Lys Asn 
                85                  90                  95      


Val Thr Gly Leu Asp Leu Leu Ser Ser Val Asp Gly Gly Thr Ser Asp 
            100                 105                 110         


Glu Ile Gln Pro Leu Tyr Met Gly Arg Cys Ser Lys Pro Ile Cys Asp 
        115                 120                 125             


Leu Ile Ser Asp Met Gly Asn Leu Val His Ala Thr Asn Ser Glu Glu 
    130                 135                 140                 


Asp Ile Lys Lys Leu Leu Pro Asp Asp Phe Lys Ser Asn Ala Asp Ser 
145                 150                 155                 160 


Leu Ile Gly Leu Asp Leu Ser Ser Val Ser Asp Thr Pro Cys Val Ser 
                165                 170                 175     


Ser Thr Asp His Asp Ser Asp Thr Val Arg Glu Gln Gln Asn Asp Thr 
            180                 185                 190         


Ser Ser Glu Leu Gln Asn Arg Glu Ile Gly Gly Ile Lys Glu Leu Gly 
        195                 200                 205             


Ile Lys Val Asp Thr Thr Leu Ser Asp Ser Tyr Asn Tyr Ser Gly Thr 
    210                 215                 220                 


Glu Asn Leu Lys Asp Lys Lys Ile Phe Asn Gln Leu Glu Ser Ile Val 
225                 230                 235                 240 


Asp Phe Asn Met Ser Ser Ala Leu Thr Arg Gln Ser Ser Lys Met Phe 
                245                 250                 255     


His Ala Lys Asp Lys Leu Gln His Lys Ser Gln Pro Cys Gly Leu Leu 
            260                 265                 270         


Lys Asp Val Gly Leu Val Lys Glu Glu Val Asp Val Ala Val Ile Thr 
        275                 280                 285             


Ala Ala Glu Cys Leu Lys Glu Glu Gly Lys Thr Ser Ala Leu Thr Cys 
    290                 295                 300                 


Ser Leu Pro Lys Asn Glu Asp Leu Cys Leu Asn Asp Ser Asn Ser Arg 
305                 310                 315                 320 


Asp Glu Asn Phe Lys Leu Pro Asp Phe Ser Phe Gln Glu Asp Lys Thr 
                325                 330                 335     


Val Ile Lys Gln Ser Ala Gln Glu Asp Ser Lys Ser Leu Asp Leu Lys 
            340                 345                 350         


Asp Asn Asp Val Ile Gln Asp Ser Ser Ser Ala Leu His Val Ser Ser 
        355                 360                 365             


Lys Asp Val Pro Ser Ser Leu Ser Cys Leu Pro Ala Ser Gly Ser Met 
    370                 375                 380                 


Ser Gly Ser Leu Ile Glu Ser Lys Ala Arg Gly Asp Phe Leu Pro Gln 
385                 390                 395                 400 


His Glu His Lys Asp Asn Ile Gln Asp Ala Val Thr Ile His Glu Glu 
                405                 410                 415     


Ile Gln Asn Ser Val Val Leu Gly Gly Glu Pro Phe Lys Glu Asn Asp 
            420                 425                 430         


Leu Leu Lys Gln Glu Lys Cys Lys Ser Ile Leu Leu Gln Ser Leu Ile 
        435                 440                 445             


Glu Gly Met Glu Asp Arg Lys Ile Asp Pro Asp Gln Thr Val Ile Arg 
    450                 455                 460                 


Ala Glu Ser Leu Asp Gly Gly Asp Thr Ser Ser Thr Val Val Glu Ser 
465                 470                 475                 480 


Gln Glu Gly Leu Ser Gly Thr His Val Pro Glu Ser Ser Asp Cys Cys 
                485                 490                 495     


Glu Gly Phe Ile Asn Thr Phe Ser Ser Asn Asp Met Asp Gly Gln Asp 
            500                 505                 510         


Leu Asp Tyr Phe Asn Ile Asp Glu Gly Ala Lys Ser Gly Pro Leu Ile 
        515                 520                 525             


Ser Asp Ala Glu Leu Asp Ala Phe Leu Thr Glu Gln Tyr Leu Gln Thr 
    530                 535                 540                 


Thr Asn Ile Lys Ser Phe Glu Glu Asn Val Asn Asp Ser Lys Ser Gln 
545                 550                 555                 560 


Met Asn Gln Ile Asp Met Lys Gly Leu Asp Asp Gly Asn Ile Asn Asn 
                565                 570                 575     


Ile Tyr Phe Asn Ala Glu Ala Gly Ala Ile Gly Glu Ser His Gly Ile 
            580                 585                 590         


Asn Ile Ile Cys Glu Thr Val Asp Lys Gln Asn Thr Ile Glu Asn Gly 
        595                 600                 605             


Leu Ser Leu Gly Glu Lys Ser Thr Ile Pro Val Gln Gln Gly Leu Pro 
    610                 615                 620                 


Thr Ser Lys Ser Glu Ile Thr Asn Gln Leu Ser Val Ser Asp Ile Asn 
625                 630                 635                 640 


Ser Gln Ser Val Gly Gly Ala Arg Pro Lys Gln Leu Phe Ser Leu Pro 
                645                 650                 655     


Ser Arg Thr Arg Ser Ser Lys Asp Leu Asn Lys Pro Asp Val Pro Asp 
            660                 665                 670         


Thr Ile Glu Ser Glu Pro Ser Thr Ala Asp Thr Val Val Pro Ile Thr 
        675                 680                 685             


Cys Ala Ile Asp Ser Thr Ala Asp Pro Gln Val Ser Phe Asn Ser Asn 
    690                 695                 700                 


Tyr Ile Asp Ile Glu Ser Asn Ser Glu Gly Gly Ser Ser Phe Val Thr 
705                 710                 715                 720 


Ala Asn Glu Asp Ser Val Pro Glu Asn Thr Cys Lys Glu Gly Leu Val 
                725                 730                 735     


Leu Gly Gln Lys Gln Pro Thr Trp Val Pro Asp Ser Glu Ala Pro Asn 
            740                 745                 750         


Cys Met Asn Cys Gln Val Lys Phe Thr Phe Thr Lys Arg Arg His His 
        755                 760                 765             


Cys Arg Ala Cys Gly Lys Val Phe Cys Gly Val Cys Cys Asn Arg Lys 
    770                 775                 780                 


Cys Lys Leu Gln Tyr Leu Glu Lys Glu Ala Arg Val Cys Val Val Cys 
785                 790                 795                 800 


Tyr Glu Thr Ile Ser Lys Ala Gln Ala Phe Glu Arg Met Met Ser Pro 
                805                 810                 815     


Thr Gly Ser Asn Leu Lys Ser Asn His Ser Asp Glu Cys Thr Thr Val 
            820                 825                 830         


Gln Pro Pro Gln Glu Asn Gln Thr Ser Ser Ile Pro Ser Pro Ala Thr 
        835                 840                 845             


Leu Pro Val Ser Ala Leu Lys Gln Pro Gly Val Glu Gly Leu Cys Ser 
    850                 855                 860                 


Lys Glu Gln Lys Arg Val Trp Phe Ala Asp Gly Ile Leu Pro Asn Gly 
865                 870                 875                 880 


Glu Val Ala Asp Thr Thr Lys Leu Ser Ser Gly Ser Lys Arg Cys Ser 
                885                 890                 895     


Glu Asp Phe Ser Pro Leu Ser Pro Asp Val Pro Met Thr Val Asn Thr 
            900                 905                 910         


Val Asp His Ser His Ser Thr Thr Val Glu Lys Pro Asn Asn Glu Thr 
        915                 920                 925             


Gly Asp Ile Thr Arg Asn Glu Ile Ile Gln Ser Pro Ile Ser Gln Val 
    930                 935                 940                 


Pro Ser Val Glu Lys Leu Ser Met Asn Thr Gly Asn Glu Gly Leu Pro 
945                 950                 955                 960 


Thr Ser Gly Ser Phe Thr Leu Asp Asp Asp Val Phe Ala Glu Thr Glu 
                965                 970                 975     


Glu Pro Ser Ser Pro Thr Gly Val Leu Val Asn Ser Asn Leu Pro Ile 
            980                 985                 990         


Ala Ser Ile Ser Asp Tyr Arg Leu  Leu Cys Asp Ile Asn  Lys Tyr Val 
        995                 1000                 1005             


Cys Asn  Lys Ile Ser Leu Leu  Pro Asn Asp Glu Asp  Ser Leu Pro 
    1010                 1015                 1020             


Pro Leu  Leu Val Ala Ser Gly  Glu Lys Gly Ser Val  Pro Val Val 
    1025                 1030                 1035             


Glu Glu  His Pro Ser His Glu  Gln Ile Ile Leu Leu  Leu Glu Gly 
    1040                 1045                 1050             


Glu Gly  Phe His Pro Val Thr  Phe Val Leu Asn Ala  Asn Leu Leu 
    1055                 1060                 1065             


Val Asn  Val Lys Phe Ile Phe  Tyr Ser Ser Asp Lys  Tyr Trp Tyr 
    1070                 1075                 1080             


Phe Ser  Thr Asn Gly Leu His  Gly Leu Gly Gln Ala  Glu Ile Ile 
    1085                 1090                 1095             


Ile Leu  Leu Leu Cys Leu Pro  Asn Glu Asp Thr Ile  Pro Lys Asp 
    1100                 1105                 1110             


Ile Phe  Arg Leu Phe Ile Thr  Ile Tyr Lys Asp Ala  Leu Lys Gly 
    1115                 1120                 1125             


Lys Tyr  Ile Glu Asn Leu Asp  Asn Ile Thr Phe Thr  Glu Ser Phe 
    1130                 1135                 1140             


Leu Ser  Ser Lys Asp His Gly  Gly Phe Leu Phe Ile  Thr Pro Thr 
    1145                 1150                 1155             


Phe Gln  Lys Leu Asp Asp Leu  Ser Leu Pro Ser Asn  Pro Phe Leu 
    1160                 1165                 1170             


Cys Gly  Ile Leu Ile Gln Lys  Leu Glu Ile Pro Trp  Ala Lys Val 
    1175                 1180                 1185             


Phe Pro  Met Arg Leu Met Leu  Arg Leu Gly Ala Glu  Tyr Lys Ala 
    1190                 1195                 1200             


Tyr Pro  Ala Pro Leu Thr Ser  Ile Arg Gly Arg Lys  Pro Leu Phe 
    1205                 1210                 1215             


Gly Glu  Ile Gly His Thr Ile  Met Asn Leu Leu Val  Asp Leu Arg 
    1220                 1225                 1230             


Asn Tyr  Gln Tyr Thr Leu His  Asn Ile Asp Gln Leu  Leu Ile His 
    1235                 1240                 1245             


Met Glu  Met Gly Lys Ser Cys  Ile Lys Ile Pro Arg  Lys Lys Tyr 
    1250                 1255                 1260             


Ser Asp  Val Met Lys Val Leu  Asn Ser Ser Asn Glu  His Val Ile 
    1265                 1270                 1275             


Ser Ile  Gly Ala Ser Phe Ser  Thr Glu Ala Asp Ser  His Leu Val 
    1280                 1285                 1290             


Cys Ile  Gln Asn Asp Gly Ile  Tyr Glu Thr Gln Ala  Asn Ser Thr 
    1295                 1300                 1305             


Thr Gly  His Pro Arg Lys Val  Thr Gly Ala Ser Phe  Val Val Phe 
    1310                 1315                 1320             


Asn Gly  Ala Leu Lys Thr Ser  Ser Gly Phe Leu Ala  Lys Ser Ser 
    1325                 1330                 1335             


Ile Val  Glu Asp Gly Leu Met  Val Gln Ile Thr Pro  Glu Thr Met 
    1340                 1345                 1350             


Asn Gly  Leu Arg Leu Ala Leu  Arg Glu Gln Lys Asp  Phe Lys Ile 
    1355                 1360                 1365             


Thr Cys  Gly Lys Val Asp Ala  Val Asp Leu Arg Glu  Tyr Val Asp 
    1370                 1375                 1380             


Ile Cys  Trp Val Asp Ala Glu  Glu Lys Gly Asn Lys  Gly Val Ile 
    1385                 1390                 1395             


Ser Ser  Val Asp Gly Ile Ser  Leu Gln Gly Phe Pro  Ser Glu Lys 
    1400                 1405                 1410             


Ile Lys  Leu Glu Ala Asp Phe  Glu Thr Asp Glu Lys  Ile Val Lys 
    1415                 1420                 1425             


Cys Thr  Glu Val Phe Tyr Phe  Leu Lys Asp Gln Asp  Leu Ser Ile 
    1430                 1435                 1440             


Leu Ser  Thr Ser Tyr Gln Phe  Ala Lys Glu Ile Ala  Met Ala Cys 
    1445                 1450                 1455             


Ser Ala  Ala Leu Cys Pro His  Leu Lys Thr Leu Lys  Ser Asn Gly 
    1460                 1465                 1470             


Met Asn  Lys Ile Gly Leu Arg  Val Ser Ile Asp Thr  Asp Met Val 
    1475                 1480                 1485             


Glu Phe  Gln Ala Gly Ser Glu  Gly Gln Leu Leu Pro  Gln His Tyr 
    1490                 1495                 1500             


Leu Asn  Asp Leu Asp Ser Ala  Leu Ile Pro Val Ile  His Gly Gly 
    1505                 1510                 1515             


Thr Ser  Asn Ser Ser Leu Pro  Leu Glu Ile Glu Leu  Val Phe Phe 
    1520                 1525                 1530             


Ile Ile  Glu His Leu Phe 
    1535                 


<210>  1057
<211>  1529
<212>  DNA
<213>  Homosapiens

<400>  1057
cgtttggttc cgcttcgctg gcgcccgccg ggctcttccc ccgccgaggc ctgtggtttg     60

tggagtcgaa tttccctgcc accagtgccc ggttagcagg ggcgccagcc tgggcgcctg    120

cgcggacggc gggcgtcgtc accatggcag catccgctgg aggcccagga tcttggagtg    180

aaaatatact ggaatatttt ctgagaaata gccagattac agcagaagac ggtgctgaga    240

tcacctggta tcatgcagct aaccacaagg cacaaacaaa tgaggcactg aaaagtactg    300

ctcacatgat agaggctgat gtccttcttc caagtgatgg atcagaacac agccagccaa    360

ttatggccca tccccctgaa acaaacagtg ataatactct acaggagtgg ctgactgaag    420

ttatgaaaag caataaaggc atcaagctgg atttcaaaag tctggcagtt gtagaaccat    480

ccatgatgct cttggaaaat gtgaagaggc atctgaagcg tcctgtatgg attaatgccg    540

atattcttcc tggtccaaat ggaaatagca aagtaataga tgcaaaacca tttttagaca    600

ccgtgacatc cttctttcca gacgtgacgt tttccctggg ttggacaaca ggatggcatc    660

ctgagaaagt caatgaaggg tacagttgga caatggtgaa agagatggaa tatatatgta    720

atgaactaag tcagcctgta acgttccctg tcagagcagc attagtcagg cagtcttgtt    780

ctcagttact ttggctgtta aagaaatcaa acaggtacag cctgactatt tggactggaa    840

aaaatgataa ctattccgtt gaagatttac tttacattag agaccatttt gacaaaaaac    900

aagttttcta tgacatcttg gaaccacaaa accatgaatt taaacaagcc attggaatca    960

aagttaatct ctaagaagaa gattctcaat tatttcctgt gttttggttt cataatcctt   1020

ctctccattg gtctgaatta attaccatat aaattatggt tattgattga cgttccaagt   1080

catctaatca agaaacgttt attgtatgct tactctgtgg gcatatgtcc ttataatagt   1140

gcacttacat aaaagatttg gaaagaagag atttatttac acacgtggcc tagtctaata   1200

ataattcagg aaaatgatac tctgcacccc ttcataaaaa tagttttgat aaactaaaga   1260

tgattggcag aatccatatg tcataaaaca ggtataaatc acatgtgctt ggcacttgca   1320

ttacagagat tatgaaaaat atggtactct tttccttttt cctagaaaac tggttatttt   1380

agagataaca aaaaaggaag agggctttta aaatgttttt aattttcaca ggggtcagca   1440

gctgtctcat atcaagatct attaatccat ttcctgaaac tgtagattaa attagataga   1500

tctagaattt ccatgtgatt gagaagcat                                     1529


<210>  1058
<211>  276
<212>  PRT
<213>  Homosapiens

<400>  1058

Met Ala Ala Ser Ala Gly Gly Pro Gly Ser Trp Ser Glu Asn Ile Leu 
1               5                   10                  15      


Glu Tyr Phe Leu Arg Asn Ser Gln Ile Thr Ala Glu Asp Gly Ala Glu 
            20                  25                  30          


Ile Thr Trp Tyr His Ala Ala Asn His Lys Ala Gln Thr Asn Glu Ala 
        35                  40                  45              


Leu Lys Ser Thr Ala His Met Ile Glu Ala Asp Val Leu Leu Pro Ser 
    50                  55                  60                  


Asp Gly Ser Glu His Ser Gln Pro Ile Met Ala His Pro Pro Glu Thr 
65                  70                  75                  80  


Asn Ser Asp Asn Thr Leu Gln Glu Trp Leu Thr Glu Val Met Lys Ser 
                85                  90                  95      


Asn Lys Gly Ile Lys Leu Asp Phe Lys Ser Leu Ala Val Val Glu Pro 
            100                 105                 110         


Ser Met Met Leu Leu Glu Asn Val Lys Arg His Leu Lys Arg Pro Val 
        115                 120                 125             


Trp Ile Asn Ala Asp Ile Leu Pro Gly Pro Asn Gly Asn Ser Lys Val 
    130                 135                 140                 


Ile Asp Ala Lys Pro Phe Leu Asp Thr Val Thr Ser Phe Phe Pro Asp 
145                 150                 155                 160 


Val Thr Phe Ser Leu Gly Trp Thr Thr Gly Trp His Pro Glu Lys Val 
                165                 170                 175     


Asn Glu Gly Tyr Ser Trp Thr Met Val Lys Glu Met Glu Tyr Ile Cys 
            180                 185                 190         


Asn Glu Leu Ser Gln Pro Val Thr Phe Pro Val Arg Ala Ala Leu Val 
        195                 200                 205             


Arg Gln Ser Cys Ser Gln Leu Leu Trp Leu Leu Lys Lys Ser Asn Arg 
    210                 215                 220                 


Tyr Ser Leu Thr Ile Trp Thr Gly Lys Asn Asp Asn Tyr Ser Val Glu 
225                 230                 235                 240 


Asp Leu Leu Tyr Ile Arg Asp His Phe Asp Lys Lys Gln Val Phe Tyr 
                245                 250                 255     


Asp Ile Leu Glu Pro Gln Asn His Glu Phe Lys Gln Ala Ile Gly Ile 
            260                 265                 270         


Lys Val Asn Leu 
        275     


<210>  1059
<211>  3763
<212>  DNA
<213>  Homosapiens

<400>  1059
attcgaggcg ccgaggagcc gaagaccaca gctcagctca gacggcgccc tagggccgca     60

cagagggtcg ggcagtgccg gagagaggtt tgaaagcgcc gccgccaact cgacagcgcg    120

tcccagcgcc ttgagctcgc ttcctcctgc tctcaggaaa aactgaggaa acgcgcctgg    180

ttccaggggt cggcggggac cgtggagacg ctgccagcat cctcaacagc ttggaaatcc    240

catcaccttg gttccctgag acttggagga ctagtaggaa ctgacagctg gctgacagaa    300

aacttatcca gggagagaag agacaaaagt gaagtgtgaa attttgaata atgttttcag    360

atgctttgca ttcagaatag acctctgagt tgggacccaa gctgtcaact gatcccaaat    420

tcctaagttc ctgacttgca ggtattgagt tctaacctcc gaagatggat gaaggtatgg    480

aaatttcaag tgaaggaaat tccttgatca aagcagtcca tcagagccgg cttcgcctca    540

caagactttt gctagaaggc ggtgcctaca ttaatgagag caacgaccgt ggggaaaccc    600

ctttaatgat cgcttgtaag accaaacatg tcgatcacca gagtgtcagt aaagccaaaa    660

tggtgaaata cctgttagag aacaatgccg atcccaacat acaggacaaa tctgggaaaa    720

cggctctgat gcatgcttgc ttagaaaaag ctggccctga agttgtttcc ttgctcctca    780

agagtggggc tgacctcagc ttgcaagacc attctagtta ctcagctctt gtttatgcta    840

taaattcaga agatacagag accctgaaag ttcttcttag tgcttgcaag gcaaaaggga    900

aagaggtcat catcatcaca acagcaaagt cgccctgtgg gaagcatact actaaacaat    960

acttaaatat gcctcctgtg gatatagatg ggtgtcattc cccagctacc tgcaccactc   1020

cttcagaaat agacatcaaa actgcctcat cgccactttc acattcttct gaaacggaac   1080

tgacgctttt tggctttaaa gatcttgagc ttgctggaag caatgatgat acctgggacc   1140

caggttcccc tgtgaggaaa cctgcattgg cccctaaggg gcccaagctc ccccacgctc   1200

caccctgggt caagagtccc ccattattaa tgcaccagaa cagagtggct tcattgcaag   1260

aggagctcca ggatattaca ccagaggaag aactatccta taaaaccaat gggctggcac   1320

tttccaagcg gttcatcact aggcaccaaa gcattgatgt aaaagacact gcacatttgc   1380

taagagcctt tgatcaggcc agctcaagga agatgtcata tgatgaaata aattgtcaat   1440

cttatctttc agaaggaaat cagcaatgca ttgaagtccc tgttgaccag gacccagatt   1500

ctaaccagac aatatttgct tccaccttaa gaagtatagt tcaaaaaaga aacttggggg   1560

caaatcacta cagctctgat tcccagctct cagctggcct tacccctcca acttcagaag   1620

acggcaaagc acttatagga aagaaaaaga tcctctcacc atctccttcc caattgtcag   1680

agtccaaaga attgttggag aatatccccc caggtcccct gagcaggaga aatcatgcag   1740

ttttagaagg gcgaggttca ggagctttcc ctttagatca cagtgttacc caaaccagac   1800

aagggtttct cccaccctta aatgtaaatt ctcaccctcc catctcagat atcaatgtca   1860

acaacaagat ttgcagcctt ctttcttgtg gtcaaaaagt gcttatgcca acagttccga   1920

ttttccctaa agaattcaaa agtaagaaaa tgttgttaag gagacaatca ttgcaaactg   1980

aacaaattaa gcaattagta aacttctagg agatgggtat aaaacacatc ttcttcaaat   2040

gtttatatca gagaaacaaa gaactagaga agaaatctta aatgttcatt cttttaaatc   2100

tcgtgattgg ttagtccata atggctagat ggattaaaat gtaatgtgat ttgtactagg   2160

cgtcatgagc ataaaaaata atacatagtt tctgttaagg gaattctctc aaacgaaagg   2220

aaagcgattt ttctcaatgc ttctaatatt taacaatctc catgtagtcc aaatttgtca   2280

ttaaaaaaaa atcaaagaaa gaaggccacg tatgttgggg taatttttaa aaattttcag   2340

attggctaaa tattttatta ggaaacagtt ttcaagtcaa taattttttt aacatttcat   2400

gttaataaat gagattgaaa ttttttatga tctctaaacc ataaaagaaa acaccgacag   2460

ctgtaaaatg ttctaagata aaaaaactcg agctacaaag aaagaatgaa ctaattcttt   2520

acaaatgttg actgaagata gataaaactc taattaaaaa tttaaaaggt taaacactgt   2580

attagagtgg gcaactaaaa tattcgtggt gtcagtttaa ttagtgtcaa actggcaagt   2640

cagagtttta caacctacta gtaatctatg ccgggtcttg ttgtttgtgc actgtgtttt   2700

gctttgcttt gttttggttt ttaaacagac ttacctgtaa agttatctta cggaattatt   2760

ctttctccat atcttttaag gaattattct ttctccatat catcttttaa ttcctgttat   2820

tagttttgga agcttatcca taagtttcca aagacaagat gatataaaag ttaaaaagca   2880

ttcctcttta cttatatcaa attattcttg tctttcaaaa agaaccaaaa aaaaaaaatt   2940

catcatggat aaaaactaag cgcttgcctt cttttaaaaa gaaaaactga tgattagatt   3000

aggttagcta aaattaatag aggcagtaga aacttaatca caaaatgtac taaatatttg   3060

gcaatattaa acaatgcctt tttatttctg atatgtagtt attagacatt tatatattaa   3120

ggataacttc cttagtgtga cattccaatc atttagtatt ttaggacctg tgaataactt   3180

ccaacaaaat taatgaatac catattagta ttataaaata ttataaagta ataattatat   3240

catctatata acttcaaagt atgatgttta tacaaagaat ccttatttca gtctagcagc   3300

ttaacaacaa aggataaatc agactataca aaacctaagt gtattaattt gatgattgtc   3360

acgtacaact ttctttgcct tccaagtaga ggtgatccta acaattggca tgatgctttt   3420

cttggtaatt tgatataagc aagttgtaat gtacatagta attatttaat tactgtggct   3480

tttattttaa aaagtaatta gaggtttttc catttcatgt cttgaacaac attaatatta   3540

attacactag aaatattttt tgattcagaa cttagaattg tacctgatat ttataggtat   3600

ttaaatgctt tctgcaagtt aaatatcgag aaaagtactt gacttcaagt tgtaaggata   3660

caatttggaa gggtatgtaa atagattagt tcataaacaa aatggtatca ataaagattt   3720

taaatatcaa aaaaaaaaaa aaaaaagaaa aaaaaaaaaa aaa                     3763


<210>  1060
<211>  514
<212>  PRT
<213>  Homosapiens

<400>  1060

Met Asp Glu Gly Met Glu Ile Ser Ser Glu Gly Asn Ser Leu Ile Lys 
1               5                   10                  15      


Ala Val His Gln Ser Arg Leu Arg Leu Thr Arg Leu Leu Leu Glu Gly 
            20                  25                  30          


Gly Ala Tyr Ile Asn Glu Ser Asn Asp Arg Gly Glu Thr Pro Leu Met 
        35                  40                  45              


Ile Ala Cys Lys Thr Lys His Val Asp His Gln Ser Val Ser Lys Ala 
    50                  55                  60                  


Lys Met Val Lys Tyr Leu Leu Glu Asn Asn Ala Asp Pro Asn Ile Gln 
65                  70                  75                  80  


Asp Lys Ser Gly Lys Thr Ala Leu Met His Ala Cys Leu Glu Lys Ala 
                85                  90                  95      


Gly Pro Glu Val Val Ser Leu Leu Leu Lys Ser Gly Ala Asp Leu Ser 
            100                 105                 110         


Leu Gln Asp His Ser Ser Tyr Ser Ala Leu Val Tyr Ala Ile Asn Ser 
        115                 120                 125             


Glu Asp Thr Glu Thr Leu Lys Val Leu Leu Ser Ala Cys Lys Ala Lys 
    130                 135                 140                 


Gly Lys Glu Val Ile Ile Ile Thr Thr Ala Lys Ser Pro Cys Gly Lys 
145                 150                 155                 160 


His Thr Thr Lys Gln Tyr Leu Asn Met Pro Pro Val Asp Ile Asp Gly 
                165                 170                 175     


Cys His Ser Pro Ala Thr Cys Thr Thr Pro Ser Glu Ile Asp Ile Lys 
            180                 185                 190         


Thr Ala Ser Ser Pro Leu Ser His Ser Ser Glu Thr Glu Leu Thr Leu 
        195                 200                 205             


Phe Gly Phe Lys Asp Leu Glu Leu Ala Gly Ser Asn Asp Asp Thr Trp 
    210                 215                 220                 


Asp Pro Gly Ser Pro Val Arg Lys Pro Ala Leu Ala Pro Lys Gly Pro 
225                 230                 235                 240 


Lys Leu Pro His Ala Pro Pro Trp Val Lys Ser Pro Pro Leu Leu Met 
                245                 250                 255     


His Gln Asn Arg Val Ala Ser Leu Gln Glu Glu Leu Gln Asp Ile Thr 
            260                 265                 270         


Pro Glu Glu Glu Leu Ser Tyr Lys Thr Asn Gly Leu Ala Leu Ser Lys 
        275                 280                 285             


Arg Phe Ile Thr Arg His Gln Ser Ile Asp Val Lys Asp Thr Ala His 
    290                 295                 300                 


Leu Leu Arg Ala Phe Asp Gln Ala Ser Ser Arg Lys Met Ser Tyr Asp 
305                 310                 315                 320 


Glu Ile Asn Cys Gln Ser Tyr Leu Ser Glu Gly Asn Gln Gln Cys Ile 
                325                 330                 335     


Glu Val Pro Val Asp Gln Asp Pro Asp Ser Asn Gln Thr Ile Phe Ala 
            340                 345                 350         


Ser Thr Leu Arg Ser Ile Val Gln Lys Arg Asn Leu Gly Ala Asn His 
        355                 360                 365             


Tyr Ser Ser Asp Ser Gln Leu Ser Ala Gly Leu Thr Pro Pro Thr Ser 
    370                 375                 380                 


Glu Asp Gly Lys Ala Leu Ile Gly Lys Lys Lys Ile Leu Ser Pro Ser 
385                 390                 395                 400 


Pro Ser Gln Leu Ser Glu Ser Lys Glu Leu Leu Glu Asn Ile Pro Pro 
                405                 410                 415     


Gly Pro Leu Ser Arg Arg Asn His Ala Val Leu Glu Gly Arg Gly Ser 
            420                 425                 430         


Gly Ala Phe Pro Leu Asp His Ser Val Thr Gln Thr Arg Gln Gly Phe 
        435                 440                 445             


Leu Pro Pro Leu Asn Val Asn Ser His Pro Pro Ile Ser Asp Ile Asn 
    450                 455                 460                 


Val Asn Asn Lys Ile Cys Ser Leu Leu Ser Cys Gly Gln Lys Val Leu 
465                 470                 475                 480 


Met Pro Thr Val Pro Ile Phe Pro Lys Glu Phe Lys Ser Lys Lys Met 
                485                 490                 495     


Leu Leu Arg Arg Gln Ser Leu Gln Thr Glu Gln Ile Lys Gln Leu Val 
            500                 505                 510         


Asn Phe 
        


<210>  1061
<211>  3932
<212>  DNA
<213>  Homosapiens

<400>  1061
tcccagacag aacctactat gtgcggcggc agctggggcg ggaaggcggg agctgggggc     60

gctgggggcg ctgcggccgc tgcggccgct gcagccgctg cagcgccagg gtccacctgg    120

tcggctgcac ctgtggagga ggaggtggat ttcaggcttc ccgtagactg gaagaatcgg    180

ctcaaaaccg cttgcctcgc aggggctgag ctggaggcag cgaggccgcc cgacgcaggc    240

ttccggcgag acatggcagg gcaaggatgg cagcccggcg gcagggcctg gcgaggagcg    300

cgagcccgcg gccgcagttc ccaggcgtct gcgggcgcga gcacgccgcg accctgcgtg    360

cgccggggcg ggggggcggg gcctcgcctg cacaaatggg gacgaggggg gcggggcggc    420

cacaatttcg cgccaaactt gaccgcgcgt tctgctgtaa cgagcgggct cggaggtcct    480

cccgctgctg tcatggttgg ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc    540

atcggcaaga acggggacct gccctggcca ccgctcagga atgaattcag atatttccag    600

agaatgacca caacctcttc agtagaaggt aaacagaatc tggtgattat gggtaagaag    660

acctggttct ccattcctga gaagaatcga cctttaaagg gtagaattaa tttagttctc    720

agcagagaac tcaaggaacc tccacaagga gctcattttc tttccagaag tctagatgat    780

gccttaaaac ttactgaaca accagaatta gcaaataaag tagacatggt ctggatagtt    840

ggtggcagtt ctgtttataa ggaagccatg aatcacccag gccatcttaa actatttgtg    900

acaaggatca tgcaagactt tgaaagtgac acgttttttc cagaaattga tttggagaaa    960

tataaacttc tgccagaata cccaggtgtt ctctctgatg tccaggagga gaaaggcatt   1020

aagtacaaat ttgaagtata tgagaagaat gattaatatg aaggtgtttt ctagtttaag   1080

ttgttccccc tccctctgaa aaaagtatgt atttttacat tagaaaaggt tttttgttga   1140

ctttagatct ataattattt ctaagcaact agtttttatt ccccactact cttgtctcta   1200

tcagatacca tttatgagac attcttgcta taactaagtg cttctccaag accccaactg   1260

agtccccagc acctgctaca gtgagctgcc attccacacc catcacatgt ggcactcttg   1320

ccagtccttg acattgtcgg gcttttcaca tgttggtaat atttattaaa gatgaagatc   1380

cacataccct tcaactgagc agtttcacta gtggaaatac caaaagcttc ctacgtgtat   1440

atccagaggt ttgtagataa atgttgccac cttgtttgta acagtgaaaa attgaaaaca   1500

acctggaagt ccagtgatgg gaaaatgagt atgtttctgt cttagattgg ggaacccaaa   1560

gcagattgca agactgaaat ttcagtgaaa gcagtgtatt tgctaggtca taccagaaat   1620

catcaattga ggtacggaga aactgaactg agaaggtaag aaaagcaatt taaagtcagc   1680

gagcaggttc tcattgataa caagctccat actgctgaga tacagggaaa tggagggggg   1740

aaagctggag tattgatccc gcccccctcc ttggttgtca gctccctgtc ctgtgtgtgg   1800

gcggaacata gtccagctgc tctatagcaa gtctcaggtg tttgcagtaa gaagctgctg   1860

gcatgcacgg gaacagtgaa tgccaaacac ttaaagcaat tcgatgttta agtatgtaag   1920

ttcttttttt tttagacagc gtttcgctct tgttgcccag gctagcatgc aatggtgtga   1980

cctcggctta ctgcaacctc cgccttccca gattcaagcg attctcctgc ctcaggctcc   2040

caagtagcta ggaccaggtg cgcgccacca cgcccggcta atttttgtat tttgtatttt   2100

tagtagagat ggggtttcac catgttggtc aggctagtct cgaactcgtg accgcaagcg   2160

attcacccac ctcagcctcc caaagtgctg ggattaccgg cttgagccac cacacccggc   2220

acatcttcat tctttttatg tagtaaaaag tataaggcca cacatggttt atttgaagta   2280

ttttataatt taaaaaaata cagaagcagg aaaaccaatt ataagttcaa gtgagggatg   2340

atggttgctt gaaccaaagg gttgcatgta gtaagaaatt gtgatttaag atatatttta   2400

aagttataag tagcaggata ttctgatgga gtttgacttt ggttttgggc ccagggagtt   2460

tcagatgcct ttgagaaatg aatgaagtag agagaaaata aaagaaaaac cagccaggca   2520

cagtggctca cacctgtaat cccagcgctt tgggaggcta aggcaggcag atcacttgag   2580

accagcttgg gcaacatggc aaagccccat ctctacaaaa aacacaaaaa ttagctgggc   2640

attgtggcgc acacctgtat tcccatctag tcaggaagct gagatggaag aattaattga   2700

gcccacgagt tcaaggctgc agtgagtcgt gattgtgcca ctgcactcca gccggggtga   2760

cagaagagac cttgtctcga aaaggaatct gaaaacaatg gaaccatgcc ttcataattc   2820

tagaaagtta ttttcaactg ataaatctat attcacccaa ataatcaagg gtgaaggtaa   2880

aataatacat ttttagacaa gcaaagactc aggggttacc tccatgtgcc ctttttaggg   2940

aagctgttgg agaaaatact ccagcaaaat gaaggagtac acaaaccaga gaatgacatg   3000

aatccagcaa ataggatcca acacaggcaa tattccagct atggagctag ctttaaaaag   3060

gaacagtaaa aatattaatc ggttagctgg gtggaatggc ccatgcctgt agtcccagct   3120

actcaggagg ctcagcagca ggacgacttg agcccaagag ttccagacca gcctggccac   3180

cttagtgaga tcccttctct taaaaataat aacttattgc cagatttggg gcatttggaa   3240

agaagttcat tgaagataaa gcaaaagtaa aaaaaaaaaa aaaaaaaaca aggggaaagg   3300

gttggttagg caatcattct agggcagaaa gaagtacagg ataggaagag cataatacac   3360

tgtttttctc aacaaggagc agtatgtaca cagtcataat gatgtgactg cttagcccct   3420

aaatatggta actactctgg gacaatatgg gaggaaaagt gaagattgtg atggtgtaag   3480

agctaaatcc tcatctgtca tatccagaaa tcactatata atatataata atgaaatgac   3540

taagttatgt gaggaaaaaa acagaagaca ttgctaaaag agttaaaagt cattgctctg   3600

gagaattagg agggatgggg caggggactg ttaggatgca ttataaactg aaaagccttt   3660

ttaaaatttt atgtattaat atatgcattc acttgaaaaa ctaaaaaaaa acaataattt   3720

ggaaaaaccc atgaaggtaa ctaacggaag gaaaaactaa gagaatgaaa agtatttgcc   3780

tctggaaaga acaactggca ggactgttgt tttcattgta agacttttgg agccatttaa   3840

ttgtacttaa ccattttcat ctatttcttt aataagaaca attccatctt aataaagagt   3900

tacacttgtt aataagtaaa aaaaaaaaaa aa                                 3932


<210>  1062
<211>  187
<212>  PRT
<213>  Homosapiens

<400>  1062

Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210>  1063
<211>  4146
<212>  DNA
<213>  Homosapiens

<400>  1063
gaccactgag acgagcggga gcgcggagca gcagcctctg ctgccctgac tttttaagaa     60

atctcaatga actatttgta gagaatcact gatccggcct gcaagcattt tgcacggcaa    120

aaatatcgat cagtgttaag tgaagatcac attttatatg cgatcttgac ttttttgtct    180

tacattatat ttttatagat tttgttataa acatggtgct gggaaaggtg aagagtttga    240

caataagctt tgactgtctt aatgacagca atgtccctgt gtattctagt ggggataccg    300

tctcaggaag ggtaaattta gaagttactg gggaaatcag agtaaaatct cttaaaattc    360

atgcaagagg acatgcgaaa gtacgctgga ctgaatctag aaacgccggc tccaatactg    420

cctatacaca gaattacact gaagaagtag agtatttcaa ccataaagac atcttaattg    480

ggcacgaaag agatgatgat aattccgaag aaggcttcca cactattcat tcaggaaggc    540

atgaatatgc attcagcttc gagcttccac agacaccact cgctacctca ttcgaaggcc    600

gacatggcag tgtgcgctat tgggtgaaag ccgaattgca caggccttgg ctactaccag    660

taaaattaaa gaaggaattt acagtctttg agcatataga tatcaacact ccttcattac    720

tgtcacccca agcaggcaca aaagaaaaga cactctgttg ctggttctgt acctcaggcc    780

caatatcctt aagtgccaaa attgaaagga agggctatac cccaggtgaa tcaattcaga    840

tatttgctga gattgagaac tgctcttccc gaatggtggt gccaaaggca gccatttacc    900

aaacacaggc cttctatgcc aaagggaaaa tgaaggaagt aaaacagctt gtggctaact    960

tgcgtgggga atccttatca tctggaaaga cagagacgtg gaatggcaag ttgctgaaaa   1020

ttccaccagt ttctccctct atcctcgact gtagtataat ccgcgtggaa tattcactaa   1080

tggtatatgt ggatattcct ggagctatgg atttatttct taatttgcca cttgtcatcg   1140

gtaccattcc tctacatcca tttggtagca gaacctcaag tgtaagcagt cagtgtagca   1200

tgaatatgaa ctggctcagt ttatcacttc ctgaaagacc tgaagcacca cccagctatg   1260

cagaagtggt aacagaggaa caaaggcgga acaatcttgc accagtgagt gcttgtgatg   1320

actttgagag agcccttcaa ggaccactgt ttgcatatat ccaggagttt cgattcttgc   1380

ctccacctct ttattcagag attgatccaa atcctgatca gtcagcagat gatagaccat   1440

cctgcccctc tcgttgaagg aacacttggt tgaatcaagt tgatgtgggt tccgaactgt   1500

atctcttccg gctgaggaca gagaagtatc ttggagacac gtttcagagg aagtggaatt   1560

acttttgccc agaaaaatgg cgaatacatg aaacaaccag tgatcatgct ttagaagcct   1620

acagcaacat tctgagactg ctccaacatg cttgaagatc taagcttttc tcttttaaaa   1680

ctggcacata ctcagagcag tcttcttagc ctatggtcgt acgtgtcaag acatcacgtt   1740

gtaaagaggg atgatttcct tcttttgatt tgaaaatttg cacatgctca atgcttacat   1800

tgtgcggttc gacgtcacta cagcttcttt tttttttttt ttttctattt ttgccagact   1860

cttgatactc ttaaaacttg tttgtggtca gcacaacaag gaacaaaaca aagctttgaa   1920

aaaactttaa catgaaaaaa cgcactgaca ttttttttta tttaatatag cctggacttt   1980

acctgcgtat gcacatgctc agaattgtct actaggctga ctatgtatca cctcttcagc   2040

ttggatccaa ttgtggattt atttacaaac atcaaatgcc ttcaagccaa tcctttttgc   2100

tgtatgtttt gcagcctact gtagtagata cgcaacagat aatgtgggaa aaaaagagat   2160

aagaggagga agctaataag agactgtcaa gattgtatac cttcttggtt tcttttaaga   2220

atttgttgcc tttctactat tacagcaaag cagcattttg ttactgactg cctaaaatca   2280

cttaatctca ggtgaacgca tcacttgcca aactgttgga atgctatttg tgttttgttg   2340

cactgttttt ttcgtttgtt tgtttgttta tttggttggc tttttggaga gggaaatttg   2400

gaaacgggac atacacaaaa gttacacacc cacattccct ttttatcatg acatacaaga   2460

agaaactagc agagctaaga atggagtgaa gaaaggcagt atggcaggca ccagcaaaga   2520

gttgagggct gttgctctta aaaattattt tttttattat tattttgaaa gtatggaagt   2580

tttccattca ctggggaaag gagggaaaag tgcatttatt tttatacaga gttacttaat   2640

tacctccaaa acacatatgt tggaaatcgc ttttgctggt gcaaagtata ttaatgagca   2700

ggaatacata cattgaggtt atgaatagag agctcaattt gtacctttgc tgtcttgctc   2760

aagcttggta tggcatgaaa actcgacttt attccaaaag taacttcaaa atttaaaata   2820

ctagaacgtt tgctgcgata aatcttttgg atttttgtgt ttttctaatg agaatactgt   2880

ttttcattac ctaaagaaca atttgctaaa catgagaaat cactcacttt gattatgtat   2940

agattacata ggaagaacaa tcacatcagt aagttatagt ttatattaaa ggtaattttc   3000

tgttggctca taacaaatat accagcattc atgatagcat ttcagcattt tccaaggtac   3060

caagtgtact tattttgttg ttgttgttgt tgttgtattt tagaaggaat tcagctctga   3120

tgtttttaaa gaaaaccagc atctctgatg ttgcaacata cgtgtaaaat gggtgttaca   3180

tctatcctgc catttaaccc cacagttaat aaagtggctg aaaataatag tagctctggc   3240

ttggtgcttg acctggttaa atactgtctt aaagctcata caaaacaaat aggcttttcc   3300

ataagtggcc tttaagaaaa catggaagac aattcatgtt tgacaaatgc tgacagggtg   3360

aagaaagccc agtgtaaaaa tgaatcgcgt tttaagtgat tcggttaaag agtttgggct   3420

cccgtagcaa actaatacta gataataagg aaatgggggt gaaatatttt tttattgttg   3480

aatcattttg tgaatgtccc cctcaaaaaa agctaatgga atatttggca taaagggcat   3540

ttggtggttt tatttttgtt tgagggggat tgtcagaaaa tcccttttct ctcttacgtc   3600

taactgacta gggaacaatt gttgatatgc atagcattgg aatacttgtc attatatact   3660

cttacaaata acacatgaag caagaatgac caatattctg ataattggca ctggatcaca   3720

aaatgtgata aaactttaaa tgtataaaac tttatcaaat aaagttttat tttccccttt   3780

aaaatgtatt tctttagagg cattactttt ttaaaaatat tggtcaattc ctgacataag   3840

atgtgaggtt cacagttgta ttccagtatt caagatagat tcctgatttt tcaattagga   3900

aaagtaaaat ccaaaatgtt agcaaaacaa agtgcaatat taaatgtttg ctttatagat   3960

tatattctat ggctgtttgt aatttctctt tttttccttt tttatttggt gctgaatatg   4020

tccttgtagg ctctgtttta agaaaacaat atgtgggaaa tgatttaatt tttcctattg   4080

ctcttccttg tggaaaataa agtgttttgt ttttttctgt tttgtataaa aaaaaaaaaa   4140

aaaaaa                                                              4146


<210>  1064
<211>  414
<212>  PRT
<213>  Homosapiens

<400>  1064

Met Val Leu Gly Lys Val Lys Ser Leu Thr Ile Ser Phe Asp Cys Leu 
1               5                   10                  15      


Asn Asp Ser Asn Val Pro Val Tyr Ser Ser Gly Asp Thr Val Ser Gly 
            20                  25                  30          


Arg Val Asn Leu Glu Val Thr Gly Glu Ile Arg Val Lys Ser Leu Lys 
        35                  40                  45              


Ile His Ala Arg Gly His Ala Lys Val Arg Trp Thr Glu Ser Arg Asn 
    50                  55                  60                  


Ala Gly Ser Asn Thr Ala Tyr Thr Gln Asn Tyr Thr Glu Glu Val Glu 
65                  70                  75                  80  


Tyr Phe Asn His Lys Asp Ile Leu Ile Gly His Glu Arg Asp Asp Asp 
                85                  90                  95      


Asn Ser Glu Glu Gly Phe His Thr Ile His Ser Gly Arg His Glu Tyr 
            100                 105                 110         


Ala Phe Ser Phe Glu Leu Pro Gln Thr Pro Leu Ala Thr Ser Phe Glu 
        115                 120                 125             


Gly Arg His Gly Ser Val Arg Tyr Trp Val Lys Ala Glu Leu His Arg 
    130                 135                 140                 


Pro Trp Leu Leu Pro Val Lys Leu Lys Lys Glu Phe Thr Val Phe Glu 
145                 150                 155                 160 


His Ile Asp Ile Asn Thr Pro Ser Leu Leu Ser Pro Gln Ala Gly Thr 
                165                 170                 175     


Lys Glu Lys Thr Leu Cys Cys Trp Phe Cys Thr Ser Gly Pro Ile Ser 
            180                 185                 190         


Leu Ser Ala Lys Ile Glu Arg Lys Gly Tyr Thr Pro Gly Glu Ser Ile 
        195                 200                 205             


Gln Ile Phe Ala Glu Ile Glu Asn Cys Ser Ser Arg Met Val Val Pro 
    210                 215                 220                 


Lys Ala Ala Ile Tyr Gln Thr Gln Ala Phe Tyr Ala Lys Gly Lys Met 
225                 230                 235                 240 


Lys Glu Val Lys Gln Leu Val Ala Asn Leu Arg Gly Glu Ser Leu Ser 
                245                 250                 255     


Ser Gly Lys Thr Glu Thr Trp Asn Gly Lys Leu Leu Lys Ile Pro Pro 
            260                 265                 270         


Val Ser Pro Ser Ile Leu Asp Cys Ser Ile Ile Arg Val Glu Tyr Ser 
        275                 280                 285             


Leu Met Val Tyr Val Asp Ile Pro Gly Ala Met Asp Leu Phe Leu Asn 
    290                 295                 300                 


Leu Pro Leu Val Ile Gly Thr Ile Pro Leu His Pro Phe Gly Ser Arg 
305                 310                 315                 320 


Thr Ser Ser Val Ser Ser Gln Cys Ser Met Asn Met Asn Trp Leu Ser 
                325                 330                 335     


Leu Ser Leu Pro Glu Arg Pro Glu Ala Pro Pro Ser Tyr Ala Glu Val 
            340                 345                 350         


Val Thr Glu Glu Gln Arg Arg Asn Asn Leu Ala Pro Val Ser Ala Cys 
        355                 360                 365             


Asp Asp Phe Glu Arg Ala Leu Gln Gly Pro Leu Phe Ala Tyr Ile Gln 
    370                 375                 380                 


Glu Phe Arg Phe Leu Pro Pro Pro Leu Tyr Ser Glu Ile Asp Pro Asn 
385                 390                 395                 400 


Pro Asp Gln Ser Ala Asp Asp Arg Pro Ser Cys Pro Ser Arg 
                405                 410                 


<210>  1065
<211>  4122
<212>  DNA
<213>  Homosapiens

<400>  1065
aggaggcgac agctgccagc cgaggaggcg cggcggagag gggactgcgg tcagctgcgt     60

ccacttgggg ctgtgcggcg gtcccgcgcc cggcgatgtt cccgggcact ccctgagtag    120

cggcagctta tcccccgccc gctagcccgc cctggtcccc ggctcgctcg ctggctggcg    180

cggccccggc cccgctctgc gtcggccccg ccgcggtgga ggcgcgcgag ggggacgcgg    240

ccggggatga gcggattgcg ggtgaactcg ccgccggggc cccgcgaagc cgtgagccgc    300

tgcttttctc cgagtcgccg ccctgccctt ggatttgaga tcatgtccat ccacatcgtg    360

gcgctgggga acgaggggga cacattccac caggacaacc agccgtcggg gcttatccgc    420

acttacctgg ggagaagccc tctggtctcc ggggacgaga gcagcttgtt gctgaacgcg    480

gccagcacgg tcgcgcgtcc ggtgttcacc gagtatcagg ccagtgcgtt tgggaatgtc    540

aagctggtgg tccacgactg tcccgtctgg gacatatttg acagtgattg gtacacttct    600

cgaaatctaa ttgggggcgc tgacatcatt gtgatcaaat acaacgttaa tgacaagttt    660

tcattccatg aagtaaagga taattatatt ccagtgataa aaagagcatt aaattcagtt    720

ccagtaatta ttgctgctgt tggtaccaga caaaatgaag agttaccttg tacatgccca    780

ctatgtacct cagacagagg gagctgtgtt agtacaactg aagggatcca acttgcaaaa    840

gaactaggag caacctatct tgaactccac agccttgatg acttctacat aggaaagtat    900

tttggaggag tgttggagta ttttatgatt caagccttaa atcagaagac aagtgaaaaa    960

atgaagaaaa gaaaaatgag caactccttt catggaatta gaccacctca acttgaacaa   1020

ccagaaaaaa tgcctgtctt aaaggctgaa gcgtcacatt ataactctga cttaaataac   1080

ttgctgttct gctgccagtg tgtggacgtg gtattttata accccgattt aaagaaagtt   1140

gtagaggccc acaagatcgt tctctgcgct gtaagccatg ttttcatgct gcttttcaat   1200

gtgaagagtc ccactgacat tcaggattcc agtatcatcc gaactaccca ggatcttttt   1260

gctataaaca gagatactgc atttccaggt gctagccatg aatcttcagg caacccacca   1320

ttacgagtca ttgttaaaga cgccctcttc tgttcttgtt tatcagacat ccttcgcttc   1380

atttattcag gtgcttttca gtgggaagaa ttggaagaag atatcaggaa gaagttgaaa   1440

gattctgggg atgtttcaaa tgtaatcgag aaagttaaat gcattttaaa aacaccagga   1500

aagattaatt gcctaaggaa ttgcaaaacc tatcaagcca gaaaaccttt gtggttttat   1560

aacacttccc tcaagttttt ccttaataag ccgatgcttg ccgatgttgt cttcgaaatt   1620

caaggtacga cagtgccagc ccacagggcc atcctggtgg cccgttgtga agtgatggca   1680

gccatgttta atggtaatta catggaagca aagagtgtcc tgattcccgt ttatggtgtt   1740

tccaaagaga ctttcttgtc atttttagaa tacctgtaca cagactcctg ctgcccagct   1800

ggcatattcc aggccatgtg tctcctgatc tgtgccgaga tgtaccaagt gtccagactg   1860

cagcacatct gtgagctgtt catcattacc cagctgcaga gcatgccaag cagggaactg   1920

gcatccatga accttgatat agttgacctg cttaaaaagg ccaagtttca ccactctgat   1980

tgcctttcaa cctggctact tcatttcatt gctactaact acctcatctt cagtcaaaag   2040

cctgaatttc aggatctttc agtggaagaa cgcagttttg ttgaaaagca cagatggccg   2100

tcgaatatgt acttgaagca gcttgcggaa tacaggaagt atattcactc ccggaaatgt   2160

cgttgcttag taatgtaacc tggagctttt atacactaca tttctttttt attattatga   2220

agaatgggat acctccaggt tccagtaaaa ttcttctgac cgaaaccaat gtgggtgtta   2280

gaaaaattac catatagctt aatatgttta ttagttctct ttggaaaaaa actaccactg   2340

tggtcttaaa agggaacaaa atataccata ggctaaaact aaggctttca ctctagaatg   2400

caaagctgtt ttgcagctgt tttcccttaa agatgtcctg ttgctttagt gatatttaga   2460

cccctctcag ttaagaaatg cttagattaa aaaaaaaaaa ttacgtagga ttaatacaga   2520

aatttaatca tgtctgatta attgctctat taaaataagg ggcatttaaa gacccagcat   2580

aaccatttgt ataatgagaa atctagggga aaaccaatca gtccaacatg agattttagg   2640

aatagaaatt tgccggccat ttggaaagtg aaatgccact tagttctcaa ttgatgacag   2700

tgtttgaatc atcataaaaa aaatacctgc ttttcatctg gacaacccaa ttgagccact   2760

ttatctcctt ttggcaatct gagtaggcgg ggaacctagg cagggctggc tttcttagcg   2820

tgtaacttgt gtagcagcac agggcccaca cttagaagga ccccacactt ggttcaaggc   2880

tctgctatag cggaaattct taataatgtt tgaagaaggg ccccatgatt tcattttgtg   2940

ctgagccctc aaaattatgt ctgtttcgtg gtgggaaata tcctatgttt tcttgctcaa   3000

acacctttct ctctgaaagc agaaaaaggc actgatataa agggaagaga aggaggctca   3060

ccggagggaa gagaacatag tgaagattcc cgcctttggg gaggtctgga ccacccaggg   3120

cctccactgc caccttggct ggcaagggag aaatgtgttg tgttgtctta gctttaaaac   3180

agtcacagtt cttgctctat catagatgaa caaatacttt cttgatcatt ctgtaagacc   3240

aggaggttgg taagagtgac taaccagcct aactttaata cacatgtata aagatgttca   3300

cagagaaaga tgctctgtag agaatttgct accgaagttg gctcaagaat ttgtttttag   3360

tgttatttac caagattagg acgtcagtgg cttaaattct ttgaattctt ttcaaggact   3420

gcaagattat ttgataaaga gtagcatgaa tcttgtgctc taatattaca cagtaagttc   3480

aaagaaagga tgtaagtcaa agacttgtta catagaggga aaatggactg ggatagagga   3540

cagactgata gtttctttct ttcatatcac atgtatagag aaataattat atcagaaact   3600

cacaaaccta gacatggaaa aacagattac tgtctattgt cagcatcatt ttcatctgta   3660

agtcactact ggaatatatt tttcttttaa tttccagtga ctttagaata cacacagttt   3720

ttccgacttt tcaaaaattt gattaaatgg ttttatagta taatattggg accccatacc   3780

gttagccctt gtatgtatac caacactgcc aaagtaaaac attaggtcag gcatggtggc   3840

tcaggcctgt aatcccagca ttttgggagg ctgaggcaag tggataactt gaggtcatga   3900

gttcgaaacc agcctggcca aaacagtgaa accccgtctc tactaaaaat acaaaattag   3960

ccagatgtgg tggcgcacac ctgtaatccc agctactcag gaagctgagg caggaaaatc   4020

gcttgaacct gggaggtgga agttgcagtg agccgagatc gcaccactgc actccagcct   4080

gggtgacaag agcgaaactc catcacaaaa aaaaaaaaaa aa                      4122


<210>  1066
<211>  611
<212>  PRT
<213>  Homosapiens

<400>  1066

Met Ser Ile His Ile Val Ala Leu Gly Asn Glu Gly Asp Thr Phe His 
1               5                   10                  15      


Gln Asp Asn Gln Pro Ser Gly Leu Ile Arg Thr Tyr Leu Gly Arg Ser 
            20                  25                  30          


Pro Leu Val Ser Gly Asp Glu Ser Ser Leu Leu Leu Asn Ala Ala Ser 
        35                  40                  45              


Thr Val Ala Arg Pro Val Phe Thr Glu Tyr Gln Ala Ser Ala Phe Gly 
    50                  55                  60                  


Asn Val Lys Leu Val Val His Asp Cys Pro Val Trp Asp Ile Phe Asp 
65                  70                  75                  80  


Ser Asp Trp Tyr Thr Ser Arg Asn Leu Ile Gly Gly Ala Asp Ile Ile 
                85                  90                  95      


Val Ile Lys Tyr Asn Val Asn Asp Lys Phe Ser Phe His Glu Val Lys 
            100                 105                 110         


Asp Asn Tyr Ile Pro Val Ile Lys Arg Ala Leu Asn Ser Val Pro Val 
        115                 120                 125             


Ile Ile Ala Ala Val Gly Thr Arg Gln Asn Glu Glu Leu Pro Cys Thr 
    130                 135                 140                 


Cys Pro Leu Cys Thr Ser Asp Arg Gly Ser Cys Val Ser Thr Thr Glu 
145                 150                 155                 160 


Gly Ile Gln Leu Ala Lys Glu Leu Gly Ala Thr Tyr Leu Glu Leu His 
                165                 170                 175     


Ser Leu Asp Asp Phe Tyr Ile Gly Lys Tyr Phe Gly Gly Val Leu Glu 
            180                 185                 190         


Tyr Phe Met Ile Gln Ala Leu Asn Gln Lys Thr Ser Glu Lys Met Lys 
        195                 200                 205             


Lys Arg Lys Met Ser Asn Ser Phe His Gly Ile Arg Pro Pro Gln Leu 
    210                 215                 220                 


Glu Gln Pro Glu Lys Met Pro Val Leu Lys Ala Glu Ala Ser His Tyr 
225                 230                 235                 240 


Asn Ser Asp Leu Asn Asn Leu Leu Phe Cys Cys Gln Cys Val Asp Val 
                245                 250                 255     


Val Phe Tyr Asn Pro Asp Leu Lys Lys Val Val Glu Ala His Lys Ile 
            260                 265                 270         


Val Leu Cys Ala Val Ser His Val Phe Met Leu Leu Phe Asn Val Lys 
        275                 280                 285             


Ser Pro Thr Asp Ile Gln Asp Ser Ser Ile Ile Arg Thr Thr Gln Asp 
    290                 295                 300                 


Leu Phe Ala Ile Asn Arg Asp Thr Ala Phe Pro Gly Ala Ser His Glu 
305                 310                 315                 320 


Ser Ser Gly Asn Pro Pro Leu Arg Val Ile Val Lys Asp Ala Leu Phe 
                325                 330                 335     


Cys Ser Cys Leu Ser Asp Ile Leu Arg Phe Ile Tyr Ser Gly Ala Phe 
            340                 345                 350         


Gln Trp Glu Glu Leu Glu Glu Asp Ile Arg Lys Lys Leu Lys Asp Ser 
        355                 360                 365             


Gly Asp Val Ser Asn Val Ile Glu Lys Val Lys Cys Ile Leu Lys Thr 
    370                 375                 380                 


Pro Gly Lys Ile Asn Cys Leu Arg Asn Cys Lys Thr Tyr Gln Ala Arg 
385                 390                 395                 400 


Lys Pro Leu Trp Phe Tyr Asn Thr Ser Leu Lys Phe Phe Leu Asn Lys 
                405                 410                 415     


Pro Met Leu Ala Asp Val Val Phe Glu Ile Gln Gly Thr Thr Val Pro 
            420                 425                 430         


Ala His Arg Ala Ile Leu Val Ala Arg Cys Glu Val Met Ala Ala Met 
        435                 440                 445             


Phe Asn Gly Asn Tyr Met Glu Ala Lys Ser Val Leu Ile Pro Val Tyr 
    450                 455                 460                 


Gly Val Ser Lys Glu Thr Phe Leu Ser Phe Leu Glu Tyr Leu Tyr Thr 
465                 470                 475                 480 


Asp Ser Cys Cys Pro Ala Gly Ile Phe Gln Ala Met Cys Leu Leu Ile 
                485                 490                 495     


Cys Ala Glu Met Tyr Gln Val Ser Arg Leu Gln His Ile Cys Glu Leu 
            500                 505                 510         


Phe Ile Ile Thr Gln Leu Gln Ser Met Pro Ser Arg Glu Leu Ala Ser 
        515                 520                 525             


Met Asn Leu Asp Ile Val Asp Leu Leu Lys Lys Ala Lys Phe His His 
    530                 535                 540                 


Ser Asp Cys Leu Ser Thr Trp Leu Leu His Phe Ile Ala Thr Asn Tyr 
545                 550                 555                 560 


Leu Ile Phe Ser Gln Lys Pro Glu Phe Gln Asp Leu Ser Val Glu Glu 
                565                 570                 575     


Arg Ser Phe Val Glu Lys His Arg Trp Pro Ser Asn Met Tyr Leu Lys 
            580                 585                 590         


Gln Leu Ala Glu Tyr Arg Lys Tyr Ile His Ser Arg Lys Cys Arg Cys 
        595                 600                 605             


Leu Val Met 
    610     


<210>  1067
<211>  1328
<212>  DNA
<213>  Homosapiens

<400>  1067
ccgcagccca tcggcatggc tcaagagttt gtgaactgca aaatccagcc tgggaaggtg     60

gttgtgttca tcaagcccac ctgcccgtac tgcaggaggg cccaagagat cctcagtcaa    120

ttgcccatca aacaagggct tctggaattt gtcgatatca cagccaccaa ccacactaac    180

gagattcaag attatttgca acagctcacg ggagcaagaa cggtgcctcg agtctttatt    240

ggtaaagatt gtataggcgg atgcagtgat ctagtctctt tgcaacagag tggggaactg    300

ctgacgcggc taaagcagat tggagctctg cagtaaccac agaacaggcc ccatgctgac    360

gtccctcctc aagagctgga tggcattgca aatgatgaca gcacttctgg tggatgaatt    420

tgggggcaca aacagctttt ttcctctttt ggctcagtat ttaaaagtgg accaacttgc    480

tcttaatcac agggcaagaa ggttgaccgg gccatcttgg ttttcttctg gatgagctct    540

ttggttttca gaagactgtg acaagttctg gcccaggatt cgctcactga ccctcaattg    600

tcctctttgg catgcgtttc ttactgttct ccatgtgtcg gcatgtctct acctctaagc    660

cagtgttttt caactatgtt tatccagact ccttctccac aatgatgaat ccacagttgg    720

ttatctgcta ctgcccatta gctaaaatca ttttgctgct tgactttatg gagtttgtat    780

tatgaaatca gtggtatttt gaatgtgttc tttctaacta catgcatctc tccactcaac    840

tccaccccat cccatcccac cttgaaaatc gctgctctga accagtgttc tccaccttgt    900

cctccacaca tctcatagga aatgttcaac aattctgtga aaggtcacag gacccaattg    960

gagaaatcat atgaaaagca tagttggtct tggtgtcata tggatcagag gcacaagtgc   1020

agaggctgtg gtcatgcgga acactctgtt atttaagatg gctatccaga taatcctgaa   1080

cactgtgtat ttattttatt tagactacca gcaaagatta aagcatgaaa tgtaaaacat   1140

ctgataaaac ttacagcccc ctacaccaag agtgtatctg tgaaagagct cctacacttt   1200

gaaaacttaa gaatccctta tcatgaagtt tgcctgttct agaattgtaa gattgttaat   1260

ttccttcaat ctctagtgac aacacttaat ttcttttcta ataaaaaaaa cctatagatg   1320

attcagtg                                                            1328


<210>  1068
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  1068

Met Ala Gln Glu Phe Val Asn Cys Lys Ile Gln Pro Gly Lys Val Val 
1               5                   10                  15      


Val Phe Ile Lys Pro Thr Cys Pro Tyr Cys Arg Arg Ala Gln Glu Ile 
            20                  25                  30          


Leu Ser Gln Leu Pro Ile Lys Gln Gly Leu Leu Glu Phe Val Asp Ile 
        35                  40                  45              


Thr Ala Thr Asn His Thr Asn Glu Ile Gln Asp Tyr Leu Gln Gln Leu 
    50                  55                  60                  


Thr Gly Ala Arg Thr Val Pro Arg Val Phe Ile Gly Lys Asp Cys Ile 
65                  70                  75                  80  


Gly Gly Cys Ser Asp Leu Val Ser Leu Gln Gln Ser Gly Glu Leu Leu 
                85                  90                  95      


Thr Arg Leu Lys Gln Ile Gly Ala Leu Gln 
            100                 105     


<210>  1069
<211>  1799
<212>  DNA
<213>  Homosapiens

<400>  1069
agaccacgaa cccaccagaa ggaagaaact ccgaacacat ctgaacatca gaaggaacaa     60

actctggaca cactgccttt aagaactgta atactcaccg tgagggcccg cggcttcatt    120

cttgaagtca gtgagaccaa gaacccacca attccagaca cagtgggatc acagagagag    180

ccaacagtcc aggccatgac aagctggcac ccagctctgc ttcacatttg tccaactggc    240

gtggctgtag ctccttcctg caaggcaatg ctgaagaagc tatggaagca agaaggaagc    300

atggattcta aaaactgaca acaaaccact tacccctatt gctcttcttc ctaaagctaa    360

aggatcaaac tgcatcacgg aagctgcaca cgatgacacc ctgtctggaa agtttttgcc    420

agagggcaaa agactgcaag cagaatatcc ctttgccatt tctcattcag gactggccgt    480

tgtctgaaag caaacctcaa ggacaggact tctggactcc gcagccactt caggctgctg    540

ctccatcgca tgaattccag caggtggcgc tgcaccccgc gcggacccgg cttgcctctc    600

ggccccaggg aggtcggttg atgagcagtc gggaagtggg tctgcgcgca ccccgctgca    660

gctgtggcaa acgcaaacga tgacacacag gcttgacgag ggcctttgtc agaagcaatg    720

gggatctggc gtcaccgcac aatggaaaac aaagtgcttc tgcctggctg gccagaatgc    780

acgtttgctc actattgatg ctggggcatt tacaggcaga atgagttcat gtgaaatttc    840

aggatctgcc atgactcaga ttcactttct gtaaaccaga gtcaacatta catttccctt    900

tactctgggc cattccttga atttttaggt caccagttgt ttttgtacta actgaaggga    960

tttgagtatt tcacaagcac cttattttta ttagcatttt tagggcatta ccaatttggg   1020

acggatctgt agtgtgagag attgttgtca ctcttagctc caaacatagg ttgactttat   1080

atattattta catgttcaga attatactgt gtagaaattc aaatgaaact tgcaaaatac   1140

ttttctggca ggaagccctg gagaggatcg ttcatggaaa caaggatgac gactggggta   1200

agaaatgcag gtgactcgtg agtggtcagg gagtggaaga gaagacggct ggaaggtttt   1260

agcattcaga aaaaaaatgg agacaactag agttgatctg aagattatgg cagaattcaa   1320

tattggggga aagaaacaag atgggggtta gaaattagaa acagcagagc tccacaggtt   1380

ggaaaggttg gaaaggattt gagcaagaga acaagaagga gcctgctaat agcaccctgg   1440

gtttacatca agagaagcac ctggagagaa ttaactcggg aggaggtggg ggcatgggaa   1500

accttttcat ctccaagagc gggcaggaac agcagctggc ctgaacttga aggtacacca   1560

ggtagcttgc gtgggccagg agaaggtgat tctcttctat gcctctctcc aacgccctgc   1620

ttctgatgct gctcctctac ctgtattgag gggaagatac atccctaaga agttccctga   1680

accccattct ttgttgtggc taactggtcc ccttggaatt tttctactaa ttttcaattc   1740

cccctctcac ctggtgaaat cttgaatctt actgttcaat aaaagttctt ctaccgaaa    1799


<210>  1070
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  1070

Met Thr Pro Cys Leu Glu Ser Phe Cys Gln Arg Ala Lys Asp Cys Lys 
1               5                   10                  15      


Gln Asn Ile Pro Leu Pro Phe Leu Ile Gln Asp Trp Pro Leu Ser Glu 
            20                  25                  30          


Ser Lys Pro Gln Gly Gln Asp Phe Trp Thr Pro Gln Pro Leu Gln Ala 
        35                  40                  45              


Ala Ala Pro Ser His Glu Phe Gln Gln Val Ala Leu His Pro Ala Arg 
    50                  55                  60                  


Thr Arg Leu Ala Ser Arg Pro Gln Gly Gly Arg Leu Met Ser Ser Arg 
65                  70                  75                  80  


Glu Val Gly Leu Arg Ala Pro Arg Cys Ser Cys Gly Lys Arg Lys Arg 
                85                  90                  95      


<210>  1071
<211>  3767
<212>  DNA
<213>  Homosapiens

<400>  1071
gataagttgg cgcgtcacct agacgtcagc ctcttacctc tcggacgtcc cgtcccagga     60

gcaaaactct agtgactttg ggcccgcccc cgtgagagtg gagggcggcc gatgagggcg    120

gttctgaagg gaacaagacc aatgagacga gcccggggcg gggcgcgggg ccggagggtg    180

gggcgggtgg cggcggtggc agtccgaggt ctggctccgc gcagtatatg acagtacgtc    240

agcagcggga tggccctagc agtggcggcg gctgcagaag cccaagcagc cgcggccgca    300

gtggaggcta gagccggagc ggcggcggcg gcggcacccc ggggagttta agatggcggc    360

gggggggaca gggggcctgc gggaggagca gcgctatggg ctgtcgtgcg gacggctggg    420

gcaggacaac atcaccgtac tgcatgtgaa gctcaccgag acggcgatcc gggcgctcga    480

gacttaccag agccacaaga atttaattcc ttttcgacct tcaatccagt tccaaggact    540

ccacgggctt gtcaaaattc ccaaaaatga tcccctcaat gaagttcata actttaactt    600

ttatttgtca aatgtgggca aagacaaccc tcagggcagc tttgactgca tccagcaaac    660

attctccagc tctggagcct cccagctcaa ttgcctggga tttatacaag ataaaattac    720

agtgtgtgca acaaacgact cgtatcagat gacacgagaa agaatgaccc aggcagagga    780

ggaatcccgc aaccgaagca caaaagttat caaacccggt ggaccatatg tagggaaaag    840

agtgcaaatt cggaaagcac ctcaagctgt ttcagataca gttcctgaga ggaaaaggtc    900

aacccccatg aaccctgcaa atacaattcg aaagacacat agcagcagca ccatctctca    960

gaggccatac agggacaggg tgattcactt actggccctg aaggcctaca agaaaccgga   1020

gctacttgct agactccaga aagatggtgt caatcaaaaa gacaagaact ccctgggagc   1080

aattctgcaa caggtagcca atctgaattc taaggacctc tcatatacct taaaggatta   1140

tgtttttaaa gagcttcaaa gagactggcc tggatacagt gaaatagaca gacggtcatt   1200

ggagtcagtg ctctctagaa aactaaatcc gtctcagaat gctacaggca ccagccgttc   1260

agaatctcct gtatgttcta gtagagatgc tgtatcttct cctcagaaac ggcttttgga   1320

ttcagagttt attgatcctt taatgaataa aaaagcccga atatctcacc tgacgaacag   1380

agtaccacca acactaaatg gtcatttgaa tcccaccagt gaaaaatcgg ctgcaggcct   1440

cccactgccc cctgcggctg ctgccatccc cacccctcca ccgctgcctt caacctatct   1500

gcccatctca catcctcctc agattgtaaa ttctaactcc aactccccta gcactccaga   1560

aggccggggg actcaagacc tacctgttga cagttttagt caaaacgata gtatctatga   1620

ggaccagcaa gacaaatata cctctaggac ttctctggaa accttacccc ctggttccgt   1680

tctactaaag tgtccaaagc ctatggaaga aaaccattca atgtctcaca aaaagtccaa   1740

aaagaagtct aaaaaacata aggaaaagga ccaaataaaa aagcacgaca ttgagactat   1800

tgaggaaaag gaggaagatc ttaagagaga agaggaaatt gccaagctaa ataactccag   1860

tccaaattcc agtggaggag ttaaagagga ttgcactgcc tccatggaac cttcagcaat   1920

tgaactccca gattatttga taaaatatat cgctatcgtc tcctatgagc aacgccagaa   1980

ttataaggat gacttcaatg cagagtatga tgagtacaga gctttgcatg ccaggatgga   2040

gactgtagct agaagattta tcaaactaga tgcacaaaga aagcgccttt ctccaggctc   2100

aaaagagtat cagaatgttc atgaagaagt cttacaagaa tatcagaaga taaagcagtc   2160

tagtcccaat taccatgaag aaaaatacag atgtgaatat cttcataaca agctggctca   2220

catcaaaagg ctaataggtg aatttgacca acagcaagca gagtcatggt cctagaactc   2280

tgcttggacc agaagatgtg aataaactta agcttattta tttaaaattc caaatgagtt   2340

gctctagatt ctaaaaaggt gaaactttgg ctgttgaaag tttcagtatt agtaaacttg   2400

agttactttt tcttttccat tttactttgc ttccctgcat ttcgaagctg ctctttctgg   2460

tcctccccac caccccaccc ccaagacttg tgtttgttaa tagaaataat ttttttaggt   2520

attggggatc cattgtctat atttcaaatc agtttttttt cctcaaaaac ttgtgtttgt   2580

tattagaaat gattttttag atattgggga tccagtgtcc acacttaaaa gttgtatgtg   2640

tttaaaaaac aacaacagta atgtgcaagg tgaaatgctt ttggataaac gtaagcctat   2700

tttctgacgt ttcttaatgc aaactctttg ccttaaatgg tagaatattt agaaatttgc   2760

acaaaattaa aaaaataaac attgtcttgg agggttaaaa aatagaaagg tgtatgtgta   2820

tagattcaca tacacatatg tatatacagg ctgacttgat ctagaacatt aaatccgccc   2880

tgcaagttaa ccccccattg caatggttgc cttaaggtgt ttgctagttg tgtacatagt   2940

gtggttaatc attagctaca ctgcttccca cttgattaga gcaatgggaa gcatactgtg   3000

gcctaccagc atctggaagt gtgtgctcga tctgtatgtg tgcagaggtg gtgtggatgt   3060

gagcgtgcat gaaggaaaaa aagctgctac tcctagtagg ccaaacgctc aggttaaaca   3120

actgacgagt gttactgtag ggtgtttttt tgtttttttg ttttttttct tctatcaaat   3180

tgctactttt gttgtggaag acaaaagcat ttccatttca acgagtttgt cagctttatt   3240

aatgttgggc aaaaattgat atgtcatgaa aatgaaacag atctatagtt ttgggacaaa   3300

attataaaat gaaatgtgta ggtaacctat ttatatactg ctataaagta ttttttgaag   3360

agagatatgc aaagaagcta ttacctacat aagaggtata tttaaagatt tttttttttt   3420

catcctggtg ccaggaatat aaaaaagagt ggatatattt aaccataaca tactgtgatt   3480

catcaaacag cacaaacttt catttcatgg agtttatctg ttgacattga tttaaactgt   3540

cacttgtttt atcatgtggg aacataagtt atgtggtcaa aaatataagg attttgaatt   3600

aatgttgatt caagttgtat tgtcttattg tattgtcttt tcaaagtgct gccagttgaa   3660

aagggaagca ttatgtttac aaatctgttt tgaaatgttt gccaaaattt tggtagtgtc   3720

tttaataaag atgtttgtct ccagcatcca gaaaaaaaaa aaaaaaa                 3767


<210>  1072
<211>  640
<212>  PRT
<213>  Homosapiens

<400>  1072

Met Ala Ala Gly Gly Thr Gly Gly Leu Arg Glu Glu Gln Arg Tyr Gly 
1               5                   10                  15      


Leu Ser Cys Gly Arg Leu Gly Gln Asp Asn Ile Thr Val Leu His Val 
            20                  25                  30          


Lys Leu Thr Glu Thr Ala Ile Arg Ala Leu Glu Thr Tyr Gln Ser His 
        35                  40                  45              


Lys Asn Leu Ile Pro Phe Arg Pro Ser Ile Gln Phe Gln Gly Leu His 
    50                  55                  60                  


Gly Leu Val Lys Ile Pro Lys Asn Asp Pro Leu Asn Glu Val His Asn 
65                  70                  75                  80  


Phe Asn Phe Tyr Leu Ser Asn Val Gly Lys Asp Asn Pro Gln Gly Ser 
                85                  90                  95      


Phe Asp Cys Ile Gln Gln Thr Phe Ser Ser Ser Gly Ala Ser Gln Leu 
            100                 105                 110         


Asn Cys Leu Gly Phe Ile Gln Asp Lys Ile Thr Val Cys Ala Thr Asn 
        115                 120                 125             


Asp Ser Tyr Gln Met Thr Arg Glu Arg Met Thr Gln Ala Glu Glu Glu 
    130                 135                 140                 


Ser Arg Asn Arg Ser Thr Lys Val Ile Lys Pro Gly Gly Pro Tyr Val 
145                 150                 155                 160 


Gly Lys Arg Val Gln Ile Arg Lys Ala Pro Gln Ala Val Ser Asp Thr 
                165                 170                 175     


Val Pro Glu Arg Lys Arg Ser Thr Pro Met Asn Pro Ala Asn Thr Ile 
            180                 185                 190         


Arg Lys Thr His Ser Ser Ser Thr Ile Ser Gln Arg Pro Tyr Arg Asp 
        195                 200                 205             


Arg Val Ile His Leu Leu Ala Leu Lys Ala Tyr Lys Lys Pro Glu Leu 
    210                 215                 220                 


Leu Ala Arg Leu Gln Lys Asp Gly Val Asn Gln Lys Asp Lys Asn Ser 
225                 230                 235                 240 


Leu Gly Ala Ile Leu Gln Gln Val Ala Asn Leu Asn Ser Lys Asp Leu 
                245                 250                 255     


Ser Tyr Thr Leu Lys Asp Tyr Val Phe Lys Glu Leu Gln Arg Asp Trp 
            260                 265                 270         


Pro Gly Tyr Ser Glu Ile Asp Arg Arg Ser Leu Glu Ser Val Leu Ser 
        275                 280                 285             


Arg Lys Leu Asn Pro Ser Gln Asn Ala Thr Gly Thr Ser Arg Ser Glu 
    290                 295                 300                 


Ser Pro Val Cys Ser Ser Arg Asp Ala Val Ser Ser Pro Gln Lys Arg 
305                 310                 315                 320 


Leu Leu Asp Ser Glu Phe Ile Asp Pro Leu Met Asn Lys Lys Ala Arg 
                325                 330                 335     


Ile Ser His Leu Thr Asn Arg Val Pro Pro Thr Leu Asn Gly His Leu 
            340                 345                 350         


Asn Pro Thr Ser Glu Lys Ser Ala Ala Gly Leu Pro Leu Pro Pro Ala 
        355                 360                 365             


Ala Ala Ala Ile Pro Thr Pro Pro Pro Leu Pro Ser Thr Tyr Leu Pro 
    370                 375                 380                 


Ile Ser His Pro Pro Gln Ile Val Asn Ser Asn Ser Asn Ser Pro Ser 
385                 390                 395                 400 


Thr Pro Glu Gly Arg Gly Thr Gln Asp Leu Pro Val Asp Ser Phe Ser 
                405                 410                 415     


Gln Asn Asp Ser Ile Tyr Glu Asp Gln Gln Asp Lys Tyr Thr Ser Arg 
            420                 425                 430         


Thr Ser Leu Glu Thr Leu Pro Pro Gly Ser Val Leu Leu Lys Cys Pro 
        435                 440                 445             


Lys Pro Met Glu Glu Asn His Ser Met Ser His Lys Lys Ser Lys Lys 
    450                 455                 460                 


Lys Ser Lys Lys His Lys Glu Lys Asp Gln Ile Lys Lys His Asp Ile 
465                 470                 475                 480 


Glu Thr Ile Glu Glu Lys Glu Glu Asp Leu Lys Arg Glu Glu Glu Ile 
                485                 490                 495     


Ala Lys Leu Asn Asn Ser Ser Pro Asn Ser Ser Gly Gly Val Lys Glu 
            500                 505                 510         


Asp Cys Thr Ala Ser Met Glu Pro Ser Ala Ile Glu Leu Pro Asp Tyr 
        515                 520                 525             


Leu Ile Lys Tyr Ile Ala Ile Val Ser Tyr Glu Gln Arg Gln Asn Tyr 
    530                 535                 540                 


Lys Asp Asp Phe Asn Ala Glu Tyr Asp Glu Tyr Arg Ala Leu His Ala 
545                 550                 555                 560 


Arg Met Glu Thr Val Ala Arg Arg Phe Ile Lys Leu Asp Ala Gln Arg 
                565                 570                 575     


Lys Arg Leu Ser Pro Gly Ser Lys Glu Tyr Gln Asn Val His Glu Glu 
            580                 585                 590         


Val Leu Gln Glu Tyr Gln Lys Ile Lys Gln Ser Ser Pro Asn Tyr His 
        595                 600                 605             


Glu Glu Lys Tyr Arg Cys Glu Tyr Leu His Asn Lys Leu Ala His Ile 
    610                 615                 620                 


Lys Arg Leu Ile Gly Glu Phe Asp Gln Gln Gln Ala Glu Ser Trp Ser 
625                 630                 635                 640 


<210>  1073
<211>  823
<212>  DNA
<213>  Homosapiens

<400>  1073
atggagatac agcgtgtggg gctggagcca ggaatatcag agttttgcca gaaacccttg     60

agtctggagt ggtacggctg gagtccagat tgcagtctgt ggaggagtgg acaggagacc    120

aagaaattct cgagttctct tcagagacca actggggatc aacaattcaa tttaattctg    180

acacccaagg aagaagagag tgcacctgat gtagtagcca ctgtaagaac tgtgttggag    240

aatgatccga ttggccagtg caagagggat tgcagagaag aagaaaccac aagcagaaaa    300

accagatgag gaaattaagc taaatattaa ctatctcaag aatattccca gaagtgactg    360

ctaaatttaa atccctgctc acaatgaaat actgtacagc aggggttctc aaactttttg    420

gtcttaggac ccttacagcc ttaaaaatta ttgagaactc caaagaactt tcaattatgt    480

gggtcataac tactgatact tactgtatta taacttgaaa ctgaaaaaat ttttaaatat    540

ttataaacat ttaaaaataa taaacccatt gtaagctaat gtaaatagca tgtttttatt    600

aaaaatcact ttgttttcca aagcaaaaaa tgtagtgaga agagaggcct tcttttacat    660

tttaatatct ggcttatgag aaaatagctg agtttctcat ttctgcttct ccatttaatc    720

tgttggtgta tattttattt aaagtacagt taacccttga agaacgtggg tctgaactgt    780

gcaggtccac ttatacatgg atttttttct aataaaagtt gca                      823


<210>  1074
<211>  102
<212>  PRT
<213>  Homosapiens

<400>  1074

Met Glu Ile Gln Arg Val Gly Leu Glu Pro Gly Ile Ser Glu Phe Cys 
1               5                   10                  15      


Gln Lys Pro Leu Ser Leu Glu Trp Tyr Gly Trp Ser Pro Asp Cys Ser 
            20                  25                  30          


Leu Trp Arg Ser Gly Gln Glu Thr Lys Lys Phe Ser Ser Ser Leu Gln 
        35                  40                  45              


Arg Pro Thr Gly Asp Gln Gln Phe Asn Leu Ile Leu Thr Pro Lys Glu 
    50                  55                  60                  


Glu Glu Ser Ala Pro Asp Val Val Ala Thr Val Arg Thr Val Leu Glu 
65                  70                  75                  80  


Asn Asp Pro Ile Gly Gln Cys Lys Arg Asp Cys Arg Glu Glu Glu Thr 
                85                  90                  95      


Thr Ser Arg Lys Thr Arg 
            100         


<210>  1075
<211>  1260
<212>  DNA
<213>  Homosapiens

<400>  1075
gactagttcc cctggcgttt ggtcacctct gcttcattct ccaccgcgcc tatggtccct     60

cttggagcca gcgtggcggg cctggcggct cccgggtggt gagagagcgg tccgggaacg    120

atgaaggcct cgcagtgctg ctgctgtctc agccacctct tggcttccgt cctcctcctg    180

ctgttgctgc ctgaactaag cgggcccctg gcagtcctgc tgcaggcagc cgaggccgcg    240

ccaggtcttg ggcctcctga ccctagacca cggacattac cgccgctgcc accgggccct    300

acccctgccc agcagccggg ccgtggtctg gctgaagctg cggggccgcg gggctccgag    360

ggaggcaatg gcagcaaccc tgtggccggg cttgagacgg acgatcacgg agggaaggcc    420

ggggaaggct cggtgggtgg cggccttgct gtgagcccca accctggcga caagcccatg    480

acccagcggg ccctgaccgt gttgatggtg gtgagcggcg cggtgctggt gtacttcgtg    540

gtcaggacgg tcaggatgag aagaagaaac cgaaagacta ggagatatgg agttttggac    600

actaacatag aaaatatgga attgacacct ttagaacagg atgatgagga tgatgacaac    660

acgttgtttg atgccaatca tcctcgaaga taagaatgtg ccttttgatg aaagaacttt    720

atctttctac aatgaagagt ggaatttcta tgtttaagga ataagaagcc actatatcaa    780

tgttgggggg gtatttaagt tacatatatt ttaacaacct ttaatttgct gttgcaataa    840

ataccgtatc cttttattat atctttatat gtatagaagt actctgttaa tgggctcaga    900

gatgttgggg ataaagtata ctgtaataat ttatctgttt gaaaattact ataaaacggt    960

gttttctgat cggtttttgt ttcctgctta ccatatgatt gtaaattgtt ttatgtatta   1020

atcagttaat gctaattatt tttgctgatg tcatatgtta aagagctata aattccaaca   1080

accaactggt gtgtaaaaat aatttaaaat ttcctttact gaaaggtatt tcccattttt   1140

gtggggaaaa gaagccaaat ttattacttt gtgttggggt ttttaaaata ttaagaaatg   1200

tctaagttat tgtttgcaaa acaataaata tgattttaaa ttctcaaaaa aaaaaaaaaa   1260


<210>  1076
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  1076

Met Lys Ala Ser Gln Cys Cys Cys Cys Leu Ser His Leu Leu Ala Ser 
1               5                   10                  15      


Val Leu Leu Leu Leu Leu Leu Pro Glu Leu Ser Gly Pro Leu Ala Val 
            20                  25                  30          


Leu Leu Gln Ala Ala Glu Ala Ala Pro Gly Leu Gly Pro Pro Asp Pro 
        35                  40                  45              


Arg Pro Arg Thr Leu Pro Pro Leu Pro Pro Gly Pro Thr Pro Ala Gln 
    50                  55                  60                  


Gln Pro Gly Arg Gly Leu Ala Glu Ala Ala Gly Pro Arg Gly Ser Glu 
65                  70                  75                  80  


Gly Gly Asn Gly Ser Asn Pro Val Ala Gly Leu Glu Thr Asp Asp His 
                85                  90                  95      


Gly Gly Lys Ala Gly Glu Gly Ser Val Gly Gly Gly Leu Ala Val Ser 
            100                 105                 110         


Pro Asn Pro Gly Asp Lys Pro Met Thr Gln Arg Ala Leu Thr Val Leu 
        115                 120                 125             


Met Val Val Ser Gly Ala Val Leu Val Tyr Phe Val Val Arg Thr Val 
    130                 135                 140                 


Arg Met Arg Arg Arg Asn Arg Lys Thr Arg Arg Tyr Gly Val Leu Asp 
145                 150                 155                 160 


Thr Asn Ile Glu Asn Met Glu Leu Thr Pro Leu Glu Gln Asp Asp Glu 
                165                 170                 175     


Asp Asp Asp Asn Thr Leu Phe Asp Ala Asn His Pro Arg Arg 
            180                 185                 190 


<210>  1077
<211>  6051
<212>  DNA
<213>  Homosapiens

<400>  1077
gctgcagaag ctgccgccac ctccaatgca caaggtgtct catctgaaaa gaaacctgag     60

ccccagggag gcggcgcgga gcgaccctgg cagagctggc gcaaacaggg cgagaggtcg    120

ctgggcagcg ttcgaggacc agagggagct cggccacaga agaccccagt gatctgatcc    180

cgggatcccg gctccaagct ctcctcgcat tttacagatt tcacccccgc gactatctcc    240

ccaaaacgga gcctttatat caagagaagg tgcgggagct ggggcaacca ggactttctc    300

gggcacccaa gatgcgctcc attaggaaga ggtggacgat ctgcacaata agtctgctcc    360

tgatctttta taagacaaaa gaaatagcaa gaactgagga gcaccaggag acgcaactca    420

tcggagatgg tgaattgtct ttgagtcggt cacttgtcaa tagctctgat aaaatcattc    480

gaaaggctgg ctcttcaatc ttccagcaca atgtagaagg ttggaaaatc aattcctctt    540

tggtcctaga gataaggaag aacatacttc gtttcttaga tgcagaacga gatgtgtcag    600

tggtcaagag cagttttaag cctggtgatg tcatacacta tgtgcttgac aggcgccgga    660

cactaaacat ttctcatgat ctacatagcc tcctacctga agtttcacca atgaagaatc    720

gcaggtttaa gacctgtgca gttgttggaa attctggcat tctgttagac agtgaatgtg    780

gaaaggagat tgacagtcac aattttgtaa taaggtgtaa tctagctcct gtggtggagt    840

ttgctgcaga tgtgggaact aaatcagatt ttattaccat gaatccatca gttgtacaaa    900

gagcatttgg aggctttcga aatgagagtg acagagaaaa atttgtgcat agactttcca    960

tgctgaatga cagtgtcctt tggattcctg ctttcatggt caaaggagga gagaagcacg   1020

tggagtgggt taatgcatta atccttaaga ataaactgaa agtgcgaact gcctatccgt   1080

cattgagact tattcatgct gtcagaggtt actggctgac caacaaagtt cctatcaaaa   1140

gacccagcac aggtcttctc atgtatacac ttgccacaag attctgtgat gaaattcacc   1200

tgtatggatt ctggcccttc cctaaggatt taaatggaaa agcggtcaaa tatcattatt   1260

atgatgactt aaaatatagg tacttttcca atgcaagccc tcacagaatg ccattagaat   1320

tcaaaacatt aaatgtgcta cataatagag gagctctaaa actgacaaca ggaaagtgtg   1380

taaagcaata aagcacattt tgaaacaaac aatatgcact tcttttctga agatgcttcc   1440

gaagatttga aaataggatc caaaacacgg ctgggtttca gcatccacca atgaactgaa   1500

aggtgaataa aggacgttca tgagaaatcg actaccagct gatgaaatac ctgcaaagtg   1560

ctctaaaaat taaatatttt gactttaagg gtcctagtaa gtgccacttc cactaagaat   1620

acagtttgaa tgtataatca gtagtgttta caagatccaa cagtgcactc atcattagtt   1680

aacaaagcaa atatgttcat cactgtcagg ctgcccacag caacaccaag catattagaa   1740

gaggaacccc aggaacgcaa ctcagacctt gggaaattaa accatccttg tcagcagaag   1800

ccaagatgga agcagtttga gcaatgaaat ccgtaagatt aaacaactca agtaaatgct   1860

tcagtcagga ctctgagtct gatcatgaat tttatgtttt aatttatgtt ttttttttgt   1920

cttctggaat ctcttttggt ttggatattg ggatgcttag aaatcctttc tgagatgcat   1980

atgagtgagg aaataaactt taagtaatta tttttaaagt tcttatactt tttaaaagct   2040

atcacacaaa gacttttttt tttttttttg tctcgctctg ttgcccaggc tggagtacag   2100

tggcgcgatc tcagctcact gcaagctccg cctcccaagt tcactccatt ctcctgcctc   2160

agcctccgga gtagctggga ctgcaggcgc ctgccaccac gcctggctaa ttttttgtat   2220

ttttagtgga gacggatttt caccgtgtta gccaggatgg tctcaatctc ctgacctcgt   2280

gatccacccg ccttggcctc ccaaagtgct gggattacag gcgtgagcca ccgtgcctgg   2340

ccgacatttt taaaaaagtt ttattttgca cggctctaaa cctccatgtt attttccagt   2400

ggtgtagaag gtaccagcta aagtgaacca ctatgtaata ttaggccatt ctaaaggaaa   2460

gatgttccat gtcatcagag atggtaaaat aggcagggaa aaaaaaatct ttggtaccaa   2520

agattacact tgtgtttcta cacagcaaac catttttctt tcatgaaaat aatatattat   2580

taacatgaat atattatttt gctattaatg tgaaagttgt ctctaaatat tttttaattt   2640

tcaaactcat actttatttt catttgaaat gtttttcaca ccttttgcat tacataataa   2700

ttttgtggaa gcattttgcc ctttagaata aatattagat tgatatagct gaaatgtgac   2760

ttccagttct ttgatattcc ccttgttatt caaatagaaa tatggaaatg ctttatatat   2820

tactgttaaa tttcttagtg cagaaataac attattaata gagtattgtt ttcaaaacag   2880

atgattaatt tcaagaggtt taacagtgaa attgtgtcaa tattttgcat ttaaaatgaa   2940

tttaattgac cgatattttc tgtagttaaa tttagtcaca atatcacata tgttcttcaa   3000

gaaacacatg aaattattaa taaagtaatt aaaaaatttt taatgtataa cagaattgac   3060

caataggcca gttttctggt aacttatgat agtagattgt ttctttagaa actgggcaga   3120

agctctgcat tctcacttgt actttgattt cttatttctt gggcaggcaa tttgaggaaa   3180

gaagaaatgg catggggaat atatatgttt tgtttcttag ggaaaacagt ctgagaaatg   3240

aataaaaagc atgaagtacg tgtgtgtgtg tgtgtgttac catggaaaag gatattcaca   3300

gtagtacagt tctcaatatt tttaattaga tgtcatattt ttttaatata gtaaaacctt   3360

gggatataga atattacatc ttttgagaat gtatgtgtct ctaagtaagt aaaatctaat   3420

gcgtatagga gactgatagc taaaaatgaa tggaacatta atgtactttt ataattaaac   3480

ctcttatcta tcagaaattg taagagaata gatacatgtt ttgaatgtaa agttgaaaag   3540

tctggtttac ttaataaatt gaaagtgatt tataaaatct aaatttggac tacttgcaaa   3600

tgataagcta ttctagtagc ctttagttta aatccaacag aaatctagaa gtcacaagca   3660

aatatcttaa aggtaaaatc catctgggca ctcatttaaa gtatatctta aaaaagcagc   3720

agcaaggtac cttgccattt ttagcatatt ttcttccttt ttcttttttc tttttttttt   3780

ttttttgaga tggagtctca ctctgtcaca caggctggaa tgcagtgatg ccatctcagc   3840

tcactgcaac ctccacctcc tgggttcaag tgattctcgt gcctcagcct cccaagtagc   3900

tggggttaca ggcgcccacc accacactcg gctaattttg tgtttttagt agagacaaag   3960

tttcaccatg ttggccaggc tggtcttgaa cttcctgacc tcaggttatc cacccacctc   4020

agcctcccaa agtgctggga ttacaggtgt gagccaccgc agccggacca tttttagtat   4080

attttcagta aatacattta aacaatgtta aggccacagc acacatatct cagccattca   4140

ttgttctgtg cattgatgtt tatctcatag atgcattgag tagtgccttt ttagcttttt   4200

cacattactt tgtcaccata tcctttgtgt tctctaaata cattgcccac ttccaaaaat   4260

gttcagcatg aaaaaaaggg cttcagtgtc gattgagatt gcttttgttc atctcaggga   4320

tttcaatagt caagaatgaa ttcagttaaa ggtatttagg gttcaaagaa gacaaactgt   4380

acaagcccat ttcattcctt gttgtatacc tttccatctg ccctcccatt ttaactatct   4440

actgtggcct ttttatggaa acagagcaag atcaatgaag gctaatggca agaataagaa   4500

aaagagttga gatttaacca atagcggagc ataaaggatc atgacaaaat caaattataa   4560

aagcatactt gaaataggtg gagctttttc ttttgaaaat atatattcac aattttaata   4620

ttttaattta ttttttacta tttaaccctg tacttggcaa tgctcaggca gctgattgtg   4680

aaatattctt gtcctttaca gaacatggtt gttattgtgc tgttgacatg aatagaccat   4740

ggaaacattt tcatcattat tattcagcct gtgctgtagt taatgttaag ttgctgaaat   4800

aaaaagtgag caagtaatag attttcttgg caaatctaat gattcagccc acaggactgt   4860

tgaaactact gcggaagttt ttctatctga aagaaggtgc tgggcattca aatgtgttca   4920

tgtattgtat atcatatgaa ttgtatatca attactaatg ggaatttcta catatatgct   4980

tacaaaagca atttatttaa gtaatgctag gggtagtgta cataccaatt agttattcag   5040

ctactataca gaaaaaggat gaacaaatta atttatttct aattgagcca gttagacata   5100

atgcatataa cgtgatattt ggttcatgaa agagttgttt tcatgtggtt attgtaggga   5160

gtatatataa ttgtggaagg ggtatgggaa gagttgtgta tagttagttg ttatctctac   5220

aagtttgaaa gttttcccat caaacattat caatatacca atgttttaaa aattgagtga   5280

gggttattat ttgtatttga tgaaagaaaa tccaaataaa gcccacctag aaatagatat   5340

tttattatat atgtgctata gatataccta tatagtacaa atagacatgt gtgatgcata   5400

tatacaatgt tatatatgtg tatatgtctg tatacacact gagtctgtaa tatgtataca   5460

ctaaatttgt gttatgctaa catcttcagg gtctgcactg tgaactcccc tggagataag   5520

taagtccact ttagaataaa gaagttcttt tgagacttca gttactaacg tgctttaaga   5580

ggtatctact ttataactga attctatgtc gttcatacgt agagttacag taagggtcta   5640

gtatgtccaa atcttaataa taaagaagaa aagtaaaggc ttcaagctag caatgtattc   5700

gaattacagt tttcagattg tggctccagg ccttgtgttt ctcatttaag tagcaccttt   5760

taataaaaac cgtttctttg tgtaggcaaa agcacaagtg tttcaaatgt aaatagcagg   5820

aaaaaaaaag agtttacaga gatagcattg ctgcacagaa taattgctac tgagtatttc   5880

ttatagaatt tgtggaactg aaagatgagg tttattctgt caagttcaag ttcattctgt   5940

tcaacactgt tttcttattg tttgtgtata gcaaccgggt attattgttt tatcatttgt   6000

aaaattgtaa aataaattaa tccctttttt tcactgaaaa aaaaaaaaaa a            6051


<210>  1078
<211>  359
<212>  PRT
<213>  Homosapiens

<400>  1078

Met Arg Ser Ile Arg Lys Arg Trp Thr Ile Cys Thr Ile Ser Leu Leu 
1               5                   10                  15      


Leu Ile Phe Tyr Lys Thr Lys Glu Ile Ala Arg Thr Glu Glu His Gln 
            20                  25                  30          


Glu Thr Gln Leu Ile Gly Asp Gly Glu Leu Ser Leu Ser Arg Ser Leu 
        35                  40                  45              


Val Asn Ser Ser Asp Lys Ile Ile Arg Lys Ala Gly Ser Ser Ile Phe 
    50                  55                  60                  


Gln His Asn Val Glu Gly Trp Lys Ile Asn Ser Ser Leu Val Leu Glu 
65                  70                  75                  80  


Ile Arg Lys Asn Ile Leu Arg Phe Leu Asp Ala Glu Arg Asp Val Ser 
                85                  90                  95      


Val Val Lys Ser Ser Phe Lys Pro Gly Asp Val Ile His Tyr Val Leu 
            100                 105                 110         


Asp Arg Arg Arg Thr Leu Asn Ile Ser His Asp Leu His Ser Leu Leu 
        115                 120                 125             


Pro Glu Val Ser Pro Met Lys Asn Arg Arg Phe Lys Thr Cys Ala Val 
    130                 135                 140                 


Val Gly Asn Ser Gly Ile Leu Leu Asp Ser Glu Cys Gly Lys Glu Ile 
145                 150                 155                 160 


Asp Ser His Asn Phe Val Ile Arg Cys Asn Leu Ala Pro Val Val Glu 
                165                 170                 175     


Phe Ala Ala Asp Val Gly Thr Lys Ser Asp Phe Ile Thr Met Asn Pro 
            180                 185                 190         


Ser Val Val Gln Arg Ala Phe Gly Gly Phe Arg Asn Glu Ser Asp Arg 
        195                 200                 205             


Glu Lys Phe Val His Arg Leu Ser Met Leu Asn Asp Ser Val Leu Trp 
    210                 215                 220                 


Ile Pro Ala Phe Met Val Lys Gly Gly Glu Lys His Val Glu Trp Val 
225                 230                 235                 240 


Asn Ala Leu Ile Leu Lys Asn Lys Leu Lys Val Arg Thr Ala Tyr Pro 
                245                 250                 255     


Ser Leu Arg Leu Ile His Ala Val Arg Gly Tyr Trp Leu Thr Asn Lys 
            260                 265                 270         


Val Pro Ile Lys Arg Pro Ser Thr Gly Leu Leu Met Tyr Thr Leu Ala 
        275                 280                 285             


Thr Arg Phe Cys Asp Glu Ile His Leu Tyr Gly Phe Trp Pro Phe Pro 
    290                 295                 300                 


Lys Asp Leu Asn Gly Lys Ala Val Lys Tyr His Tyr Tyr Asp Asp Leu 
305                 310                 315                 320 


Lys Tyr Arg Tyr Phe Ser Asn Ala Ser Pro His Arg Met Pro Leu Glu 
                325                 330                 335     


Phe Lys Thr Leu Asn Val Leu His Asn Arg Gly Ala Leu Lys Leu Thr 
            340                 345                 350         


Thr Gly Lys Cys Val Lys Gln 
        355                 


<210>  1079
<211>  1887
<212>  DNA
<213>  Homosapiens

<400>  1079
gctgcagaag ctgccgccac ctccaatgca caaggtgtct catctgaaaa gaaacctgag     60

ccccagggag gcggcgcgga gcgaccctgg cagagctggc gcaaacaggg cgagaggtcg    120

ctgggcagcg ttcgaggacc agagggagct cggccacaga agaccccagt gatctgatcc    180

cgggatcccg gctccaagct ctcctcgcat tttacagatt tcacccccgc gactatctcc    240

ccaaaacgga gcctttatat caagagaagg tgcgggagct ggggcaacca ggactttctc    300

gggcacccaa gatgcgctcc attaggaaga ggtggacgat ctgcacaata agtctgctcc    360

tgatctttta taagacaaaa gaaatagcaa gaactgagga gcaccaggag acgcaactca    420

tcggagatgg tgaattgtct ttgagtcggt cacttgtcaa tagctctgat aaaatcattc    480

gaaaggctgg ctcttcaatc ttccagcaca atgtagaagg ttggaaaatc aattcctctt    540

tggtcctaga gataaggaag aacatacttc gtttcttaga tgcagaacga gatgtgtcag    600

tggtcaagag cagttttaag cctggtgatg tcatacacta tgtgcttgac aggcgccgga    660

cactaaacat ttctcatgat ctacatagcc tcctacctga agtttcacca atgaagaatc    720

gcaggtttaa gacctgtgca gttgttggaa attctggcat tctgttagac agtgaatgtg    780

gaaaggagat tgacagtcac aattttgtaa taaggtgagc tttcttctgc tttttgagat    840

tgtaagtttt tcaaagatat tttacttggg ggtggaaaac tgttagaaaa ttttaaagta    900

ttactaaaac ctcaaacaaa tatttgtcta tgatatcctt ttctgtgcaa catttaaatt    960

acatttaccc tggaatagaa tattataatt attgcgtagt tgaaagaaaa agtgatcctg   1020

tcatagcaac aagattcaca cagctttttt tggtgaggtg aggggggagg caaatggcaa   1080

ttttattaaa tttaatattc cacacaaact tttttcttag tatctcttct tcatactcat   1140

tagttttgtg tgattttatt tgttgtataa agattatgaa tattactatg gaatgatgta   1200

atagatttat gttaatgtta ctttttatta ataattatct aggagatagt aagaacatag   1260

tttagcaagt ttatatttga tatcctgagc catatttctt taatttctct ttatatgtgg   1320

tatttgtgta tgttagtata tttgaatttt atgttttttt aacataatta agcgtgcatg   1380

tttgtttttc attaacggtt aaaagatatt tgatgaattg tgtgtttgat taacctatta   1440

actgaaaaaa actcaacagt agaaatggaa ttataatcac atcataaata taagcagttt   1500

ttaatgatca atttttatat ctgtacagtt tttttggatt gttttagttc cttagaaaaa   1560

ttagctaaat gacagaaaca tggatattga aatatgaaat agtacaatat aaagatagat   1620

agaaaagtat gctgagttga catgttgaaa aacacagtct cttgaagata tactggaata   1680

cattattttt gaatattttg aatatttttt gaatattttt aaataaagtc ttaaaagcat   1740

aaataggtaa ctacttttaa aaaaaaagtc atgagaaatc acactcaagc attatcaagt   1800

gaagaaaatt cataatagca aataaaactg caaacatttt accttaaaaa aaaaaaaaaa   1860

aaaaaaaaaa aaaaaaaaaa aaaaaaa                                       1887


<210>  1080
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  1080

Met Arg Ser Ile Arg Lys Arg Trp Thr Ile Cys Thr Ile Ser Leu Leu 
1               5                   10                  15      


Leu Ile Phe Tyr Lys Thr Lys Glu Ile Ala Arg Thr Glu Glu His Gln 
            20                  25                  30          


Glu Thr Gln Leu Ile Gly Asp Gly Glu Leu Ser Leu Ser Arg Ser Leu 
        35                  40                  45              


Val Asn Ser Ser Asp Lys Ile Ile Arg Lys Ala Gly Ser Ser Ile Phe 
    50                  55                  60                  


Gln His Asn Val Glu Gly Trp Lys Ile Asn Ser Ser Leu Val Leu Glu 
65                  70                  75                  80  


Ile Arg Lys Asn Ile Leu Arg Phe Leu Asp Ala Glu Arg Asp Val Ser 
                85                  90                  95      


Val Val Lys Ser Ser Phe Lys Pro Gly Asp Val Ile His Tyr Val Leu 
            100                 105                 110         


Asp Arg Arg Arg Thr Leu Asn Ile Ser His Asp Leu His Ser Leu Leu 
        115                 120                 125             


Pro Glu Val Ser Pro Met Lys Asn Arg Arg Phe Lys Thr Cys Ala Val 
    130                 135                 140                 


Val Gly Asn Ser Gly Ile Leu Leu Asp Ser Glu Cys Gly Lys Glu Ile 
145                 150                 155                 160 


Asp Ser His Asn Phe Val Ile Arg 
                165             


<210>  1081
<211>  5334
<212>  DNA
<213>  Homosapiens

<400>  1081
cccacgccgc gccttccggt tggtccttga ggcgacgggt gaggcacagc tgagcgccaa     60

agccacaggc tggggcgcta acgcccccgc tcagcgctct gcgctccaga cagctgcgag    120

ctggagtagg aaggttcagg cggtggcgga gagtgcgctg gaggctggag ggccaggagg    180

cgggaagctt cccgcacggg ggcgctgtca cctgcctgtg ggaggagcca gagagggacc    240

tggctctgct gctctgaagc accggagtcg ggagaaccca tccagacatg aagagcgcca    300

aaggtattga gaacttggct tttgtcccct ccagcccaga catcctgcgc cgcttgtctg    360

cgtcgccctc ccaaatcgaa gtctctgcct tgtcctctga cccccaaaga gagaattctc    420

agccacagga gcttcagaag ccccaggagc cccagaagtc accagagcca tctctgcctt    480

cagcccctcc caatgtctcc gaagagaagc tccggtcact gtcgctgtcc gagtttgagg    540

aggggtctta cggctggagg aacttccatc ctcaatgtct ccagcgctgc aacacacctg    600

gaggctttct gcttcactac tgcctcttgg ccgtcacgca aggtattgta gttaatggcc    660

tagtaaatat tagcatttcc actgttgaga agcgttatga aatgaagagt tccctgactg    720

gcctgatttc atcaagctac gatatttcat tctgtttgtt gtctttattt gtatcattct    780

ttggtgaaag aggacataag ccgagatggc ttgcatttgc agcctttatg attggactgg    840

gagcacttgt attctcattg ccacaatttt tcagtggaga atataaattg gggtctcttt    900

ttgaagacac ttgtgtaaca acaaggaata gcaccagttg tacatcttca acttcttcac    960

tttctaacta cttgtatgtc ttcatcttgg gacaactatt gctgggggca ggaggaactc   1020

ctctttatac tctgggaaca gcctttcttg atgattctgt gcccacacac aagtcttctc   1080

tctatatagg aaccggttat gctatgtcaa tcttaggccc tgctattggc tatgtattgg   1140

gaggacaact gctaaccata tacattgatg ttgctatggg agaaagcact gatgtcactg   1200

aggatgatcc gcgatggttg ggagcttggt ggattgggtt tcttctatca tggatctttg   1260

cttggtcttt aataatacct ttttcttgct ttccaaaaca tttaccaggt acagcagaaa   1320

ttcaagctgg aaaaacttcc caggctcatc agagtaatag taatgcagat gtgaaatttg   1380

gaaaaagtat taaagatttt ccagctgctc taaagaattt gatgaagaat gctgtcttta   1440

tgtgtttagt tctatcaact tcttcagaag ccttaattac tactggattt gctacatttt   1500

tacctaaatt tatagaaaat caattcggat tgacatccag cttcgcagct actcttggag   1560

gggctgtttt aattcctgga gctgctctcg gtcaaatttt aggtggcttc cttgtttcaa   1620

aattcagaat gacatgtaaa aacacaatga agtttgcact gttcacatct ggagttgcac   1680

ttacgctgag ttttgtattt atgtatgcca aatgtgaaaa tgagccattt gctggtgtat   1740

ctgaatcata taatgggact ggagaattgg gaaacttgat agccccttgt aatgccaatt   1800

gtaactgttc gcgatcatat tattatcctg tctgtggaga tggagtccaa tatttttctc   1860

cctgctttgc aggctgttca aacccagttg cacacaggaa gccaaaggta tattacaact   1920

gttcctgtat tgaaaggaaa acagaaataa catccactgc agaaactttt ggttttgaag   1980

ctaaagctgg aaaatgtgaa actcattgtg cgaaactgcc catattcctt tgcattttct   2040

ttattgtaat tatttttacc tttatggccg gtactcctat aactgtgtct atcctaaggt   2100

gtgttaatca cagacaacgg tccctagcct tgggaataca atttatggtc cttcgattat   2160

tagggacaat tcctggacca attatatttg gtttcacaat agacagcaca tgtattcttt   2220

gggatataaa tgattgtgga attaaaggag cttgctggat ttatgataac atcaagatgg   2280

cccatatgct agtagccata agtgttactt gtaaagttat caccatgttc ttcaatggat   2340

ttgcaatctt tttgtataaa ccacctccat cagccacaga tgtgtcattt cataaagaga   2400

atgcagttgt gactaatgtt ttagcagaac aggatctcaa caaaatagta aaagaagggt   2460

gaaatgggaa aagagaagac tgttttacac ctggaaaatt tacctcgatt tttaagaaca   2520

cacattgcca tggcaggatt atctatccaa tatggacaat catatttaca aaattgatgt   2580

ttttataatc aaatgtattt ttttacttat gtagtttttg ttttatgcaa gaaacagacc   2640

tgtgccttca aagcccacgt aaagcctcaa aacacagcac acacacacac gagcacacac   2700

acacacacac acacgaacac acacacacac acacacacgc acacatacac acttatttcc   2760

tattcccatt gtctaggtat gaaatcctca agcaataaca agaaaaaagg cccacaatta   2820

gaaaaattta catttaaaaa aaatgttgtt tctatcccca ttacaacttg tttaatttta   2880

attttcattg tcaatatttt gagcttagaa catttatggt ataaaaattt aaactaatca   2940

aagttgtgtg atgatttccg ggaattatta ttgaaagcct atgaatttaa aaccaggttt   3000

accatgtaat ttgtttttaa atttatgtat actagcctgg cctttctcca agcaaattat   3060

tgaactatta gaatatgtta gttatcatcc ttgtgtctta gtatatagtg aatacagaaa   3120

catcagcatt gtatacacat attttcactt taactcaaga attccaggag gtaatttgtt   3180

gatattacaa tttttaacac atttatgatt ctgtgataat attattcaat tgcatatatt   3240

tcagaggaaa gtaccagtca gtaaagaaaa atgccaacta aacatgaaac tattgatcaa   3300

tacttatata cctttaattt ttcctatttg aaaagccaac cacttaacac attactcata   3360

gcacctaaga cagtgccttg catagtgtag tcatctatta ttattgttta attagaatat   3420

taaaccctac cctttaactc agcagtcccc aacctttttt gcatcaggga ccatttttgt   3480

ggaagacaat ttttccatgg gggaagaagg tatggttttg agatgaaact gctccacctc   3540

agaccatcag gcattagtta gattctcata aggagagtgc aacctagatc ccttgcatgt   3600

gcagttccca atggagtgtg cactcctatg agaatctaat gccactactg atctaacaag   3660

aggtggagct caggcagtaa tgctcactca cctgcctctc agctcaccaa ctgtgtggcc   3720

cgattcctaa caggccacac acagcccagg gctggggacc cctgctttaa ctgatgcatt   3780

gatttgataa agtattttac aagcctgata atgttataac cctgtttatt caggtcagat   3840

ttatgccaac tttgctgaga atatggaggg tatagatgag tgaacatcaa caaacataac   3900

ttctaccatg gttaagaatt ttacttagga aaagtattga agttcaaatc cagatagtat   3960

tacatttgaa attgttataa gggttattaa tttaataaaa ttcatcatca ggtttcccct   4020

ataagctttc tcctaggtta attttccaca agcattgttt tatatacact gtaatcagga   4080

taacacaagc ttagtgttag atcttgtagg aaaccaagat tagaaacatt agaaatttgc   4140

agaatttaag aaattatgtt ttgtggtaat ctatggccaa cgatgttaga acctagcgca   4200

attgtaaagt gaaattcaag gagaaggaat gaggagttag ggaagcagca tacttgaata   4260

ttagagaagg agaggagctg tgggtcagga atcagagaga cctgctaaaa ccagacagat   4320

ataaacacca aagacggaag ccaaataggt agccaaaaat ccagatattt gagaagcagg   4380

aaatttatag caaccaaaga aatagggcaa gagaggcagg tgaacacaca tgatacctca   4440

attgacaatc ttcctcccac caagccagac acgttgtaaa tgctgcttcc tattggagcc   4500

cagaaaaaag gaaaaggaaa gtttaggctt tctttgtcct ttgtgtggaa gcagggaatt   4560

ggattgaaga ctttcatagt tgtaacataa aggcaaatcc tgaggaactc actgatggag   4620

atgtgaaatg gcagtaagga agaaaacaga ataactgaac aaatatatta gtctagggcc   4680

acttaattta gaggaagaaa aaaaatcaac ccatccatag aaatagtttg ataaacaggt   4740

cactaaatca ttggcgttta taaagattct tagctatcaa gggctgcatt gtattttata   4800

tactcagttt tataaggtga tactttttaa ataagcgctt taatgaaaat ggttagactg   4860

aaaataattt tggtccttaa aaggagtcag gagcttttat atataaggta catattttaa   4920

aagaatacct cctttataac agggttttac agacactacc ataatttata atcattattt   4980

tttacttttg ggttcaccta gatcatatga gttgatgtga tacttctaga acaaaattat   5040

tcatagtgcg ttttttgtaa tttatgattg ttaagtaagc ttgacttata aattgacatt   5100

gtaattgtgt acataattgg atatatgtgt taaaatttaa catttagatt tacttaattg   5160

tagaaaatac aaatgtaaaa cttacacatg gaaagaactg tatgcagttg actttactat   5220

gtaaattgga gggaaacaaa gttttagatc cattttcttt caaaattttc tttattgtaa   5280

agtatgcaaa atatatattc ataccattta ttaaatcaga atgtttatac aaaa         5334


<210>  1082
<211>  724
<212>  PRT
<213>  Homosapiens

<400>  1082

Met Lys Ser Ala Lys Gly Ile Glu Asn Leu Ala Phe Val Pro Ser Ser 
1               5                   10                  15      


Pro Asp Ile Leu Arg Arg Leu Ser Ala Ser Pro Ser Gln Ile Glu Val 
            20                  25                  30          


Ser Ala Leu Ser Ser Asp Pro Gln Arg Glu Asn Ser Gln Pro Gln Glu 
        35                  40                  45              


Leu Gln Lys Pro Gln Glu Pro Gln Lys Ser Pro Glu Pro Ser Leu Pro 
    50                  55                  60                  


Ser Ala Pro Pro Asn Val Ser Glu Glu Lys Leu Arg Ser Leu Ser Leu 
65                  70                  75                  80  


Ser Glu Phe Glu Glu Gly Ser Tyr Gly Trp Arg Asn Phe His Pro Gln 
                85                  90                  95      


Cys Leu Gln Arg Cys Asn Thr Pro Gly Gly Phe Leu Leu His Tyr Cys 
            100                 105                 110         


Leu Leu Ala Val Thr Gln Gly Ile Val Val Asn Gly Leu Val Asn Ile 
        115                 120                 125             


Ser Ile Ser Thr Val Glu Lys Arg Tyr Glu Met Lys Ser Ser Leu Thr 
    130                 135                 140                 


Gly Leu Ile Ser Ser Ser Tyr Asp Ile Ser Phe Cys Leu Leu Ser Leu 
145                 150                 155                 160 


Phe Val Ser Phe Phe Gly Glu Arg Gly His Lys Pro Arg Trp Leu Ala 
                165                 170                 175     


Phe Ala Ala Phe Met Ile Gly Leu Gly Ala Leu Val Phe Ser Leu Pro 
            180                 185                 190         


Gln Phe Phe Ser Gly Glu Tyr Lys Leu Gly Ser Leu Phe Glu Asp Thr 
        195                 200                 205             


Cys Val Thr Thr Arg Asn Ser Thr Ser Cys Thr Ser Ser Thr Ser Ser 
    210                 215                 220                 


Leu Ser Asn Tyr Leu Tyr Val Phe Ile Leu Gly Gln Leu Leu Leu Gly 
225                 230                 235                 240 


Ala Gly Gly Thr Pro Leu Tyr Thr Leu Gly Thr Ala Phe Leu Asp Asp 
                245                 250                 255     


Ser Val Pro Thr His Lys Ser Ser Leu Tyr Ile Gly Thr Gly Tyr Ala 
            260                 265                 270         


Met Ser Ile Leu Gly Pro Ala Ile Gly Tyr Val Leu Gly Gly Gln Leu 
        275                 280                 285             


Leu Thr Ile Tyr Ile Asp Val Ala Met Gly Glu Ser Thr Asp Val Thr 
    290                 295                 300                 


Glu Asp Asp Pro Arg Trp Leu Gly Ala Trp Trp Ile Gly Phe Leu Leu 
305                 310                 315                 320 


Ser Trp Ile Phe Ala Trp Ser Leu Ile Ile Pro Phe Ser Cys Phe Pro 
                325                 330                 335     


Lys His Leu Pro Gly Thr Ala Glu Ile Gln Ala Gly Lys Thr Ser Gln 
            340                 345                 350         


Ala His Gln Ser Asn Ser Asn Ala Asp Val Lys Phe Gly Lys Ser Ile 
        355                 360                 365             


Lys Asp Phe Pro Ala Ala Leu Lys Asn Leu Met Lys Asn Ala Val Phe 
    370                 375                 380                 


Met Cys Leu Val Leu Ser Thr Ser Ser Glu Ala Leu Ile Thr Thr Gly 
385                 390                 395                 400 


Phe Ala Thr Phe Leu Pro Lys Phe Ile Glu Asn Gln Phe Gly Leu Thr 
                405                 410                 415     


Ser Ser Phe Ala Ala Thr Leu Gly Gly Ala Val Leu Ile Pro Gly Ala 
            420                 425                 430         


Ala Leu Gly Gln Ile Leu Gly Gly Phe Leu Val Ser Lys Phe Arg Met 
        435                 440                 445             


Thr Cys Lys Asn Thr Met Lys Phe Ala Leu Phe Thr Ser Gly Val Ala 
    450                 455                 460                 


Leu Thr Leu Ser Phe Val Phe Met Tyr Ala Lys Cys Glu Asn Glu Pro 
465                 470                 475                 480 


Phe Ala Gly Val Ser Glu Ser Tyr Asn Gly Thr Gly Glu Leu Gly Asn 
                485                 490                 495     


Leu Ile Ala Pro Cys Asn Ala Asn Cys Asn Cys Ser Arg Ser Tyr Tyr 
            500                 505                 510         


Tyr Pro Val Cys Gly Asp Gly Val Gln Tyr Phe Ser Pro Cys Phe Ala 
        515                 520                 525             


Gly Cys Ser Asn Pro Val Ala His Arg Lys Pro Lys Val Tyr Tyr Asn 
    530                 535                 540                 


Cys Ser Cys Ile Glu Arg Lys Thr Glu Ile Thr Ser Thr Ala Glu Thr 
545                 550                 555                 560 


Phe Gly Phe Glu Ala Lys Ala Gly Lys Cys Glu Thr His Cys Ala Lys 
                565                 570                 575     


Leu Pro Ile Phe Leu Cys Ile Phe Phe Ile Val Ile Ile Phe Thr Phe 
            580                 585                 590         


Met Ala Gly Thr Pro Ile Thr Val Ser Ile Leu Arg Cys Val Asn His 
        595                 600                 605             


Arg Gln Arg Ser Leu Ala Leu Gly Ile Gln Phe Met Val Leu Arg Leu 
    610                 615                 620                 


Leu Gly Thr Ile Pro Gly Pro Ile Ile Phe Gly Phe Thr Ile Asp Ser 
625                 630                 635                 640 


Thr Cys Ile Leu Trp Asp Ile Asn Asp Cys Gly Ile Lys Gly Ala Cys 
                645                 650                 655     


Trp Ile Tyr Asp Asn Ile Lys Met Ala His Met Leu Val Ala Ile Ser 
            660                 665                 670         


Val Thr Cys Lys Val Ile Thr Met Phe Phe Asn Gly Phe Ala Ile Phe 
        675                 680                 685             


Leu Tyr Lys Pro Pro Pro Ser Ala Thr Asp Val Ser Phe His Lys Glu 
    690                 695                 700                 


Asn Ala Val Val Thr Asn Val Leu Ala Glu Gln Asp Leu Asn Lys Ile 
705                 710                 715                 720 


Val Lys Glu Gly 
                


<210>  1083
<211>  2544
<212>  DNA
<213>  Homosapiens

<400>  1083
tttgcctcct gccctaggag aaacgttcgc tctggaggct tgggcggcaa gagccccttg     60

tggccaccga gtcctccgac gccctcgcca ggctggcctt tgggttggcc caggcaggac    120

gggcagccga gagcactcgg gccgcgtcgc caggagccgc ccagggtgag ccatgttcgt    180

aggcgtcgcc cggcactctg ggagccagga tgaagtctca aggggagtag agccgctgga    240

ggccgcgcgg gcccagcctg ctaaggacag gagggccaag ggaaccccga agtcctcgaa    300

gcccgggaaa aaacaccggt atctgagact acttccagag gccttgataa ggttcggcgg    360

tttccgaaaa aggaaaaaag ccaagtcctc agtttccaag aagccgggag aagtggatga    420

cagtttggag cagccctgtg gtttgggctg cttagtcagc acctgctgtg agtgttgcaa    480

taacattcgc tgcttcatga ttttctactg catcctgctc atatgtcaag gtgtggtgtt    540

tggtcttata gatgtcagca ttggcgattt tcagaaggaa tatcaactga aaaccattga    600

gaagttggca ttggaaaaga gttacgatat ttcatctggc ctggtagcaa tatttatagc    660

attctatgga gacagaaaaa aagtaatatg gtttgtagct tcctcctttt taataggact    720

tggatcactt ttatgtgctt ttccatccat taatgaagaa aataaacaaa gtaaggtagg    780

aattgaagat atttgcgaag aaataaaggt tgtcagtggt tgccagagca gtggtatatc    840

attccaatca aaatacctgt ctttcttcat ccttgggcag actgtgcagg gaatagcagg    900

aatgcctctt tatatccttg gaataacctt tattgatgag aatgttgcta cacactcagc    960

tggtatctat ttaggtattg cagaatgtac atcaatgatt ggatatgctc tgggttatgt   1020

gctaggagca ccactagtta aagtccctga gaatactact tctgcaacaa acactacagt   1080

caataatggt agtccagaat ggctatggac ttggtggatt aattttcttt ttgccgctgt   1140

cgttgcatgg tgtacattaa taccattgtc atgctttcca aacaatatgc caggttcaac   1200

acggataaaa gctaggaaac gtaaacagct tcattttttt gacagcagac ttaaagatct   1260

gaaacttgga actaatatca aggatttatg tgctgctctt tggattctga tgaagaatcc   1320

agtgctcata tgcctagctc tgtcaaaagc tacagaatat ttagttatta ttggagcttc   1380

tgaatttttg cctatatatt tagaaaatca gtttatatta acacccactg tggcaactac   1440

acttgcagga cttgttttaa ttccaggagg tgcacttggc cagcttctgg gaggtgtcat   1500

tgtttccaca ttagaaatgt cttgtaaagc ccttatgaga tttataatgg ttacatctgt   1560

gatatcactt atactgcttg tgtttattat ttttgtacgc tgtaatccag tgcaatttgc   1620

tgggatcaat gaagattatg atggaacagg gaagttggga aacctcacgg ctccttgcaa   1680

tgaaaaatgt agatgctcat cttcaattta ttcttctata tgtggaagag atgatattga   1740

atatttttct ccctgctttg cagggtgtac atattctaaa gcacaaaacc aaaaaaagat   1800

gtactacaat tgttcttgca ttaaagaagg attaataact gcagatgcag aaggtgattt   1860

tattgatgcc agacccggga aatgtgatgc aaagtgctat aagttacctt tgttcattgc   1920

ttttatcttt tctacactta tattttctgg tttttctggt gtaccaatcg tcttggccat   1980

gacgcgggtt gtacctgaca aactgcgttc tctggccttg ggtgtaagct atgtgatttt   2040

gagaatattt gggactattc ctggaccatc aatctttaaa atgtcaggag aaacttcttg   2100

tattttacgg gatgttaata aatgtggaca cacaggacgt tgttggatat ataacaagac   2160

aaaaatggct ttcttattgg taggaatatg ttttctttgc aaactatgca ctatcatctt   2220

cactactatt gcatttttca tatacaaacg tcgtctaaat gagaacactg acttcccaga   2280

tgtaactgtg aagaatccaa aagttaagaa aaaagaagaa actgacttgt aactggatca   2340

tcattgtgat tgcagatcat ttgaggatca gagtgtgaaa acgagtttct cttttacaga   2400

ttctccaaga tttgtttctg tgcccaactt tcagaagagg aaaatcacac attatgttta   2460

cataagtagc aaaaatatat ttatggtgat ctgcattttc ataataaagt gtcctattgt   2520

gaaaaaaaaa aaaaaaaaaa aaaa                                          2544


<210>  1084
<211>  719
<212>  PRT
<213>  Homosapiens

<400>  1084

Met Phe Val Gly Val Ala Arg His Ser Gly Ser Gln Asp Glu Val Ser 
1               5                   10                  15      


Arg Gly Val Glu Pro Leu Glu Ala Ala Arg Ala Gln Pro Ala Lys Asp 
            20                  25                  30          


Arg Arg Ala Lys Gly Thr Pro Lys Ser Ser Lys Pro Gly Lys Lys His 
        35                  40                  45              


Arg Tyr Leu Arg Leu Leu Pro Glu Ala Leu Ile Arg Phe Gly Gly Phe 
    50                  55                  60                  


Arg Lys Arg Lys Lys Ala Lys Ser Ser Val Ser Lys Lys Pro Gly Glu 
65                  70                  75                  80  


Val Asp Asp Ser Leu Glu Gln Pro Cys Gly Leu Gly Cys Leu Val Ser 
                85                  90                  95      


Thr Cys Cys Glu Cys Cys Asn Asn Ile Arg Cys Phe Met Ile Phe Tyr 
            100                 105                 110         


Cys Ile Leu Leu Ile Cys Gln Gly Val Val Phe Gly Leu Ile Asp Val 
        115                 120                 125             


Ser Ile Gly Asp Phe Gln Lys Glu Tyr Gln Leu Lys Thr Ile Glu Lys 
    130                 135                 140                 


Leu Ala Leu Glu Lys Ser Tyr Asp Ile Ser Ser Gly Leu Val Ala Ile 
145                 150                 155                 160 


Phe Ile Ala Phe Tyr Gly Asp Arg Lys Lys Val Ile Trp Phe Val Ala 
                165                 170                 175     


Ser Ser Phe Leu Ile Gly Leu Gly Ser Leu Leu Cys Ala Phe Pro Ser 
            180                 185                 190         


Ile Asn Glu Glu Asn Lys Gln Ser Lys Val Gly Ile Glu Asp Ile Cys 
        195                 200                 205             


Glu Glu Ile Lys Val Val Ser Gly Cys Gln Ser Ser Gly Ile Ser Phe 
    210                 215                 220                 


Gln Ser Lys Tyr Leu Ser Phe Phe Ile Leu Gly Gln Thr Val Gln Gly 
225                 230                 235                 240 


Ile Ala Gly Met Pro Leu Tyr Ile Leu Gly Ile Thr Phe Ile Asp Glu 
                245                 250                 255     


Asn Val Ala Thr His Ser Ala Gly Ile Tyr Leu Gly Ile Ala Glu Cys 
            260                 265                 270         


Thr Ser Met Ile Gly Tyr Ala Leu Gly Tyr Val Leu Gly Ala Pro Leu 
        275                 280                 285             


Val Lys Val Pro Glu Asn Thr Thr Ser Ala Thr Asn Thr Thr Val Asn 
    290                 295                 300                 


Asn Gly Ser Pro Glu Trp Leu Trp Thr Trp Trp Ile Asn Phe Leu Phe 
305                 310                 315                 320 


Ala Ala Val Val Ala Trp Cys Thr Leu Ile Pro Leu Ser Cys Phe Pro 
                325                 330                 335     


Asn Asn Met Pro Gly Ser Thr Arg Ile Lys Ala Arg Lys Arg Lys Gln 
            340                 345                 350         


Leu His Phe Phe Asp Ser Arg Leu Lys Asp Leu Lys Leu Gly Thr Asn 
        355                 360                 365             


Ile Lys Asp Leu Cys Ala Ala Leu Trp Ile Leu Met Lys Asn Pro Val 
    370                 375                 380                 


Leu Ile Cys Leu Ala Leu Ser Lys Ala Thr Glu Tyr Leu Val Ile Ile 
385                 390                 395                 400 


Gly Ala Ser Glu Phe Leu Pro Ile Tyr Leu Glu Asn Gln Phe Ile Leu 
                405                 410                 415     


Thr Pro Thr Val Ala Thr Thr Leu Ala Gly Leu Val Leu Ile Pro Gly 
            420                 425                 430         


Gly Ala Leu Gly Gln Leu Leu Gly Gly Val Ile Val Ser Thr Leu Glu 
        435                 440                 445             


Met Ser Cys Lys Ala Leu Met Arg Phe Ile Met Val Thr Ser Val Ile 
    450                 455                 460                 


Ser Leu Ile Leu Leu Val Phe Ile Ile Phe Val Arg Cys Asn Pro Val 
465                 470                 475                 480 


Gln Phe Ala Gly Ile Asn Glu Asp Tyr Asp Gly Thr Gly Lys Leu Gly 
                485                 490                 495     


Asn Leu Thr Ala Pro Cys Asn Glu Lys Cys Arg Cys Ser Ser Ser Ile 
            500                 505                 510         


Tyr Ser Ser Ile Cys Gly Arg Asp Asp Ile Glu Tyr Phe Ser Pro Cys 
        515                 520                 525             


Phe Ala Gly Cys Thr Tyr Ser Lys Ala Gln Asn Gln Lys Lys Met Tyr 
    530                 535                 540                 


Tyr Asn Cys Ser Cys Ile Lys Glu Gly Leu Ile Thr Ala Asp Ala Glu 
545                 550                 555                 560 


Gly Asp Phe Ile Asp Ala Arg Pro Gly Lys Cys Asp Ala Lys Cys Tyr 
                565                 570                 575     


Lys Leu Pro Leu Phe Ile Ala Phe Ile Phe Ser Thr Leu Ile Phe Ser 
            580                 585                 590         


Gly Phe Ser Gly Val Pro Ile Val Leu Ala Met Thr Arg Val Val Pro 
        595                 600                 605             


Asp Lys Leu Arg Ser Leu Ala Leu Gly Val Ser Tyr Val Ile Leu Arg 
    610                 615                 620                 


Ile Phe Gly Thr Ile Pro Gly Pro Ser Ile Phe Lys Met Ser Gly Glu 
625                 630                 635                 640 


Thr Ser Cys Ile Leu Arg Asp Val Asn Lys Cys Gly His Thr Gly Arg 
                645                 650                 655     


Cys Trp Ile Tyr Asn Lys Thr Lys Met Ala Phe Leu Leu Val Gly Ile 
            660                 665                 670         


Cys Phe Leu Cys Lys Leu Cys Thr Ile Ile Phe Thr Thr Ile Ala Phe 
        675                 680                 685             


Phe Ile Tyr Lys Arg Arg Leu Asn Glu Asn Thr Asp Phe Pro Asp Val 
    690                 695                 700                 


Thr Val Lys Asn Pro Lys Val Lys Lys Lys Glu Glu Thr Asp Leu 
705                 710                 715                 


<210>  1085
<211>  1574
<212>  DNA
<213>  Homosapiens

<400>  1085
gcttctctcc atcttgtgat tcctttttcc tcctgaaccc tccagtgggg gtgcgagttt     60

gtctttatca ccccccatcc caccgccttc ttttcttctc gctctcctac ccctccccag    120

cttggtgggc gcctctttcc tttctcgccc cctttcattt ttatttattc atatttattt    180

ggcgcccgct ctctctctgt ccctttgcct gcctccctcc ctccggatcc ccgctctctc    240

cccggagtgg cgcgtcgggg gctccgccgc tggccaggcg tgatgttgca cgtggagatg    300

ttgacgctgg tgtttctggt gctctggatg tgtgtgttca gccaggaccc gggctccaag    360

gccgtcgccg accgctacgc tgtctactgg aacagcagca accccagatt ccagaggggt    420

gactaccata ttgatgtctg tatcaatgac tacctggatg ttttctgccc tcactatgag    480

gactccgtcc cagaagataa gactgagcgc tatgtcctct acatggtgaa ctttgatggc    540

tacagtgcct gcgaccacac ttccaaaggg ttcaagagat gggaatgtaa ccggcctcac    600

tctccaaatg gaccgctgaa gttctctgaa aaattccagc tcttcactcc cttttctcta    660

ggatttgaat tcaggccagg ccgagaatat ttctacatct cctctgcaat cccagataat    720

ggaagaaggt cctgtctaaa gctcaaagtc tttgtgagac caacaaatag ctgtatgaaa    780

actataggtg ttcatgatcg tgttttcgat gttaacgaca aagtagaaaa ttcattagaa    840

ccagcagatg acaccgtaca tgagtcagcc gagccatccc gcggcgagaa cgcggcacaa    900

acaccaagga tacccagccg ccttttggca atcctactgt tcctcctggc gatgcttttg    960

acattatagc acagtctcct cccatcactt gtcacagaaa acatcagggt cttggaacac   1020

cagagatcca cctaactgct catcctaaga agggacttgt tattgggttt tggcagatgt   1080

cagatttttg ttttctttct ttcagcctga attctaagca acaacttcag gttgggggcc   1140

taaacttgtt cctgcctccc tcaccccacc ccgccccacc cccagccctg gcccttggct   1200

tctctcaccc ctcccaaatt aaatggactc cagatgaaaa tgccaaattg tcatagtgac   1260

accagtggtt cgtcagctcc tgtgcattct cctctaagaa ctcacctccg ttagcgcact   1320

gtgtcagcgg gctatggaca aggaagaata gtggcagatg cagccagcgc tggctagggc   1380

tgggagggtt ttgctctcct atgcaatatt tatgccttct cattcagaac tgtaagatga   1440

tcgcgcaggg catcatgtca ccatgtcagg tccggagggg aggtattaag aatagatacg   1500

atattacacc atttcctata ggagtatgta aatgaacagg cttctaaaag gttgagacac   1560

tggttttttt tttt                                                     1574


<210>  1086
<211>  228
<212>  PRT
<213>  Homosapiens

<400>  1086

Met Leu His Val Glu Met Leu Thr Leu Val Phe Leu Val Leu Trp Met 
1               5                   10                  15      


Cys Val Phe Ser Gln Asp Pro Gly Ser Lys Ala Val Ala Asp Arg Tyr 
            20                  25                  30          


Ala Val Tyr Trp Asn Ser Ser Asn Pro Arg Phe Gln Arg Gly Asp Tyr 
        35                  40                  45              


His Ile Asp Val Cys Ile Asn Asp Tyr Leu Asp Val Phe Cys Pro His 
    50                  55                  60                  


Tyr Glu Asp Ser Val Pro Glu Asp Lys Thr Glu Arg Tyr Val Leu Tyr 
65                  70                  75                  80  


Met Val Asn Phe Asp Gly Tyr Ser Ala Cys Asp His Thr Ser Lys Gly 
                85                  90                  95      


Phe Lys Arg Trp Glu Cys Asn Arg Pro His Ser Pro Asn Gly Pro Leu 
            100                 105                 110         


Lys Phe Ser Glu Lys Phe Gln Leu Phe Thr Pro Phe Ser Leu Gly Phe 
        115                 120                 125             


Glu Phe Arg Pro Gly Arg Glu Tyr Phe Tyr Ile Ser Ser Ala Ile Pro 
    130                 135                 140                 


Asp Asn Gly Arg Arg Ser Cys Leu Lys Leu Lys Val Phe Val Arg Pro 
145                 150                 155                 160 


Thr Asn Ser Cys Met Lys Thr Ile Gly Val His Asp Arg Val Phe Asp 
                165                 170                 175     


Val Asn Asp Lys Val Glu Asn Ser Leu Glu Pro Ala Asp Asp Thr Val 
            180                 185                 190         


His Glu Ser Ala Glu Pro Ser Arg Gly Glu Asn Ala Ala Gln Thr Pro 
        195                 200                 205             


Arg Ile Pro Ser Arg Leu Leu Ala Ile Leu Leu Phe Leu Leu Ala Met 
    210                 215                 220                 


Leu Leu Thr Leu 
225             


<210>  1087
<211>  2515
<212>  DNA
<213>  Homosapiens

<400>  1087
cggcggcagc agcccatgcc tccggtgcaa cagctgcgcc tcctccggtg ccccggcggc     60

gggggcggga gataacctgt ccctgctgct ccgcacctcc tcgcccggcg gcgccttccg    120

gacccgcacc tcctcgccgc tgtcgggctc gtcctgctgc tgctgctgct gctcgtcgcg    180

ccggggcagc cagctcaatg tgagcgagct gacgccgtcc agccatgcca gtgcgctccg    240

gcagcagtac gcgcagcagt ccgcgcagca gtcggcgtcc gcctcccagt accaccagtg    300

ccacagcctg cagcccgccg ccagccccac gggcagcctc ggcagtctgg gctccgggcc    360

cccgctctcg caccaccacc accacccgca cccggcgcac caccagcacc accagcccca    420

ggcgcgccgc gagagcaacc ccttcaccga aatagccatg agcagctgca ggtacaacgg    480

gggcgtcatg cggccgctca gcaacttgag cgcgtcccgc cggaacctgc acgagatgga    540

ctcagaggcg cagcccctgc agccccccgc gtctgtcgga ggaggtggcg gcgcgtcctc    600

cccgtctgca gccgctgccg ccgccgccgc tgtttcgtcc tcagcccccg agatcgtggt    660

gtctaagccc gagcacaaca actccaacaa cctggcgctc tatggaaccg gcggcggagg    720

cagcactgga ggaggcggcg gcggtggcgg gagcgggcac ggcagcagca gtggcaccaa    780

gtccagcaaa aagaaaaacc agaacatcgg ctacaagctg ggccaccggc gcgccctgtt    840

cgaaaagcgc aagcggctca gcgactacgc gctcatcttc ggcatgttcg gcatcgtggt    900

catggtcatc gagaccgagc tgtcgtgggg cgcctacgac aaggcgtcgc tgtattcctt    960

agctctgaaa tgccttatca gtctctccac gatcatcctg ctcggtctga tcatcgtgta   1020

ccacgccagg gaaatacagt tgttcatggt ggacaatgga gcagatgact ggagaatagc   1080

catgacttat gagcgtattt tcttcatctg cttggaaata ctggtgtgtg ctattcatcc   1140

catacctggg aattatacat tcacatggac ggcccggctt gccttctcct atgccccatc   1200

cacaaccacc gctgatgtgg atattatttt atctatacca atgttcttaa gactctatct   1260

gattgccaga gtcatgcttt tacatagcaa acttttcact gatgcctcct ctagaagcat   1320

tggagcactt aataagataa acttcaatac acgttttgtt atgaagactt taatgactat   1380

atgcccagga actgtactct tggtttttag tatctcatta tggataattg ccgcatggac   1440

tgtccgagct tgtgaaaggt accatgatca acaggatgtt actagcaact tccttggagc   1500

gatgtggttg atatcaataa cttttctctc cattggttat ggtgacatgg tacctaacac   1560

atactgtgga aaaggagtct gcttacttac tggaattatg ggtgctggtt gcacagccct   1620

ggtggtagct gtagtggcaa ggaagctaga acttaccaaa gcagaaaaac acgtgcacaa   1680

tttcatgatg gatactcagc tgactaaaag agtaaaaaat gcagctgcca atgtactcag   1740

ggaaacatgg ctaatttaca aaaatacaaa gctagtgaaa aagatagatc atgcaaaagt   1800

aagaaaacat caacgaaaat tcctgcaagc tattcatcaa ttaagaagtg taaaaatgga   1860

gcagaggaaa ctgaatgacc aagcaaacac tttggtggac ttggcaaaga cccagaacat   1920

catgtatgat atgatttctg acttaaacga aaggagtgaa gacttcgaga agaggattgt   1980

taccctggaa acaaaactag agactttgat tggtagcatc cacgccctcc ctgggctcat   2040

aagccagacc atcaggcagc agcagagaga tttcattgag gctcagatgg agagctacga   2100

caagcacgtc acttacaatg ctgagcggtc ccggtcctcg tccaggaggc ggcggtcctc   2160

ttccacagca ccaccaactt catcagagag tagctagaag agaataagtt aaccacaaaa   2220

taagactttt tgccatcata tggtcaatat tttagctttt attgtaaagc ccctatggtt   2280

ctaatcagcg ttatccgggt tctgatgtca gaatcctggg aacctgaaca ctaagtttta   2340

ggccaaaatg agtgaaaact cttttttttt ctttcagatg cacagggaat gcacctatta   2400

ttgctatata gattgttcct cctgtaattt cactaacttt ttattcatgc acttcaaaca   2460

aactttacta ctacattata tgatatataa taaaaaaagt taatttctgc acata        2515


<210>  1088
<211>  579
<212>  PRT
<213>  Homosapiens

<400>  1088

Met Ser Ser Cys Arg Tyr Asn Gly Gly Val Met Arg Pro Leu Ser Asn 
1               5                   10                  15      


Leu Ser Ala Ser Arg Arg Asn Leu His Glu Met Asp Ser Glu Ala Gln 
            20                  25                  30          


Pro Leu Gln Pro Pro Ala Ser Val Gly Gly Gly Gly Gly Ala Ser Ser 
        35                  40                  45              


Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Val Ser Ser Ser Ala Pro 
    50                  55                  60                  


Glu Ile Val Val Ser Lys Pro Glu His Asn Asn Ser Asn Asn Leu Ala 
65                  70                  75                  80  


Leu Tyr Gly Thr Gly Gly Gly Gly Ser Thr Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly His Gly Ser Ser Ser Gly Thr Lys Ser Ser Lys Lys 
            100                 105                 110         


Lys Asn Gln Asn Ile Gly Tyr Lys Leu Gly His Arg Arg Ala Leu Phe 
        115                 120                 125             


Glu Lys Arg Lys Arg Leu Ser Asp Tyr Ala Leu Ile Phe Gly Met Phe 
    130                 135                 140                 


Gly Ile Val Val Met Val Ile Glu Thr Glu Leu Ser Trp Gly Ala Tyr 
145                 150                 155                 160 


Asp Lys Ala Ser Leu Tyr Ser Leu Ala Leu Lys Cys Leu Ile Ser Leu 
                165                 170                 175     


Ser Thr Ile Ile Leu Leu Gly Leu Ile Ile Val Tyr His Ala Arg Glu 
            180                 185                 190         


Ile Gln Leu Phe Met Val Asp Asn Gly Ala Asp Asp Trp Arg Ile Ala 
        195                 200                 205             


Met Thr Tyr Glu Arg Ile Phe Phe Ile Cys Leu Glu Ile Leu Val Cys 
    210                 215                 220                 


Ala Ile His Pro Ile Pro Gly Asn Tyr Thr Phe Thr Trp Thr Ala Arg 
225                 230                 235                 240 


Leu Ala Phe Ser Tyr Ala Pro Ser Thr Thr Thr Ala Asp Val Asp Ile 
                245                 250                 255     


Ile Leu Ser Ile Pro Met Phe Leu Arg Leu Tyr Leu Ile Ala Arg Val 
            260                 265                 270         


Met Leu Leu His Ser Lys Leu Phe Thr Asp Ala Ser Ser Arg Ser Ile 
        275                 280                 285             


Gly Ala Leu Asn Lys Ile Asn Phe Asn Thr Arg Phe Val Met Lys Thr 
    290                 295                 300                 


Leu Met Thr Ile Cys Pro Gly Thr Val Leu Leu Val Phe Ser Ile Ser 
305                 310                 315                 320 


Leu Trp Ile Ile Ala Ala Trp Thr Val Arg Ala Cys Glu Arg Tyr His 
                325                 330                 335     


Asp Gln Gln Asp Val Thr Ser Asn Phe Leu Gly Ala Met Trp Leu Ile 
            340                 345                 350         


Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp Met Val Pro Asn Thr 
        355                 360                 365             


Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly Ile Met Gly Ala Gly 
    370                 375                 380                 


Cys Thr Ala Leu Val Val Ala Val Val Ala Arg Lys Leu Glu Leu Thr 
385                 390                 395                 400 


Lys Ala Glu Lys His Val His Asn Phe Met Met Asp Thr Gln Leu Thr 
                405                 410                 415     


Lys Arg Val Lys Asn Ala Ala Ala Asn Val Leu Arg Glu Thr Trp Leu 
            420                 425                 430         


Ile Tyr Lys Asn Thr Lys Leu Val Lys Lys Ile Asp His Ala Lys Val 
        435                 440                 445             


Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile His Gln Leu Arg Ser 
    450                 455                 460                 


Val Lys Met Glu Gln Arg Lys Leu Asn Asp Gln Ala Asn Thr Leu Val 
465                 470                 475                 480 


Asp Leu Ala Lys Thr Gln Asn Ile Met Tyr Asp Met Ile Ser Asp Leu 
                485                 490                 495     


Asn Glu Arg Ser Glu Asp Phe Glu Lys Arg Ile Val Thr Leu Glu Thr 
            500                 505                 510         


Lys Leu Glu Thr Leu Ile Gly Ser Ile His Ala Leu Pro Gly Leu Ile 
        515                 520                 525             


Ser Gln Thr Ile Arg Gln Gln Gln Arg Asp Phe Ile Glu Ala Gln Met 
    530                 535                 540                 


Glu Ser Tyr Asp Lys His Val Thr Tyr Asn Ala Glu Arg Ser Arg Ser 
545                 550                 555                 560 


Ser Ser Arg Arg Arg Arg Ser Ser Ser Thr Ala Pro Pro Thr Ser Ser 
                565                 570                 575     


Glu Ser Ser 
            


<210>  1089
<211>  1457
<212>  DNA
<213>  Homosapiens

<400>  1089
cttcaacact gtggaagctt tgttctttcg ctcttttgca ataaatcttg ctactgctca     60

ctctttgggt ccacactgcc tttatgagct gtaacactca ccgcgaaagg tctgcagctt    120

cactcctgaa gccagcgagc ccacgagccc acagggagga atgaacaact ccagatgcac    180

cgccttaaga gctgtaacac tcacggcgaa ggtctgcagc ttcactcctg agccagcgag    240

accaggaacc caccagaagg aagaaactcc gaacacatcc gaacatcaga aggaacaaac    300

tccagacggc gccaccttaa gagctgtaac actcaccgcc agggtccagg gcttcgttct    360

tgaagtcagt gagaccaaga acccaccaat tccggacgca gtaccatgat caacaggatg    420

ttactagcaa cttccttgga gcgatgtggt tgatatcaat aacttttctc tccattggtt    480

atggtgacat ggtacctaac acatactgtg gaaaaggagt ctgcttactt actggaatta    540

tgggtgctgg ttgcacagcc ctggtggtag ctgtagtggc aaggaagcta gaacttacca    600

aagcagaaaa acacgtgcac aatttcatga tggatactca gctgactaaa agagtaaaaa    660

atgcagctgc caatgtactc agggaaacat ggctaattta caaaaataca aagctagtga    720

aaaagataga tcatgcaaaa gtaagaaaac atcaacgaaa attcctgcaa gctattcatc    780

aattaagaag tgtaaaaatg gagcagagga aactgaatga ccaagcaaac actttggtgg    840

acttggcaaa gacccagaac atcatgtatg atatgatttc tgacttaaac gaaaggagtg    900

aagacttcga gaagaggatt gttaccctgg aaacaaaact agagactttg attggtagca    960

tccacgccct ccctgggctc ataagccaga ccatcaggca gcagcagaga gatttcattg   1020

aggctcagat ggagagctac gacaagcacg tcacttacaa tgctgagcgg tcccggtcct   1080

cgtccaggag gcggcggtcc tcttccacag caccaccaac ttcatcagag agtagctaga   1140

agagaataag ttaaccacaa aataagactt tttgccatca tatggtcaat attttagctt   1200

ttattgtaaa gcccctatgg ttctaatcag cgttatccgg gttctgatgt cagaatcctg   1260

ggaacctgaa cactaagttt taggccaaaa tgagtgaaaa ctcttttttt ttctttcaga   1320

tgcacaggga atgcacctat tattgctata tagattgttc ctcctgtaat ttcactaact   1380

ttttattcat gcacttcaaa caaactttac tactacatta tatgatatat aataaaaaaa   1440

gttaatttct gcacata                                                  1457


<210>  1090
<211>  231
<212>  PRT
<213>  Homosapiens

<400>  1090

Met Trp Leu Ile Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp Met 
1               5                   10                  15      


Val Pro Asn Thr Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly Ile 
            20                  25                  30          


Met Gly Ala Gly Cys Thr Ala Leu Val Val Ala Val Val Ala Arg Lys 
        35                  40                  45              


Leu Glu Leu Thr Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
    50                  55                  60                  


Thr Gln Leu Thr Lys Arg Val Lys Asn Ala Ala Ala Asn Val Leu Arg 
65                  70                  75                  80  


Glu Thr Trp Leu Ile Tyr Lys Asn Thr Lys Leu Val Lys Lys Ile Asp 
                85                  90                  95      


His Ala Lys Val Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile His 
            100                 105                 110         


Gln Leu Arg Ser Val Lys Met Glu Gln Arg Lys Leu Asn Asp Gln Ala 
        115                 120                 125             


Asn Thr Leu Val Asp Leu Ala Lys Thr Gln Asn Ile Met Tyr Asp Met 
    130                 135                 140                 


Ile Ser Asp Leu Asn Glu Arg Ser Glu Asp Phe Glu Lys Arg Ile Val 
145                 150                 155                 160 


Thr Leu Glu Thr Lys Leu Glu Thr Leu Ile Gly Ser Ile His Ala Leu 
                165                 170                 175     


Pro Gly Leu Ile Ser Gln Thr Ile Arg Gln Gln Gln Arg Asp Phe Ile 
            180                 185                 190         


Glu Ala Gln Met Glu Ser Tyr Asp Lys His Val Thr Tyr Asn Ala Glu 
        195                 200                 205             


Arg Ser Arg Ser Ser Ser Arg Arg Arg Arg Ser Ser Ser Thr Ala Pro 
    210                 215                 220                 


Pro Thr Ser Ser Glu Ser Ser 
225                 230     


<210>  1091
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1091
gagggaagga gggagggaag cagccgctga cccgtggcat gagctggatg cggtgtccgt     60

tgcaggacta gggcgccgac atgaacctgc accaggtgct gaccggggct gtgaaccctg    120

gcgaccactg cttctccgtg ggcagcattg gcgaccagcg cttcacggct tatgcatctg    180

gatgtgacat tgtaatactg ggaagcgatt ttgaaagatt acagataatc ccaggagcta    240

aacatggaaa tattcaagtg ggatgtgtag actgttcaat gcaacaaggc aagattgcag    300

cgtcttatgg aaatgttatc tccatttttg aaccagttaa cctaccaaaa caaaagaaaa    360

atttggaatt atatagtcag tggcagaaaa gtggccaatt ttttctggaa tcaatagcac    420

acaatataac ctgggatccc acaggcagtc gtcttttaac tggttccagc tatttgcaac    480

tctggtccaa tactaacttg gagaagccaa ctgaagatga aaatttaaat aaaacagatc    540

ttaactttgg agattggaaa tgcatttggc attgcaaaac tgcttcccaa gttcatttaa    600

tgaaattttc accagatgga gaattttttg ccactgctgg gaaggatgac tgtcttttga    660

aggtttggta taatgtagaa aactggcgga cagctgttac ttctccagat ggaagttcag    720

aaaaacaatc ccaaggagaa attgactttt cttttgtgta tctggcccat cctcgagcag    780

taaatggatt ttcctggcgt aaaacaagca aatatatgcc tagggcttct gtatgtaatg    840

tactgttgac ttgctgcaaa gataatgtgt gtcgtctttg ggtagagaca tttttaccaa    900

atgattgttt gctatacgga ggtgactgca gccattggac tgaatcaatt aatttaacaa    960

ataacttcaa gagaaatgct tccagtaaag aacgagttca aaatgcttta gaagtaaatc   1020

tgagacattt tcgtagaggt cggaggagat cacttgctct tgtagcacat acgggatatc   1080

taccacatca gcaggatcct catcatgttc acaggaacac tccactgcat gccaatgcac   1140

tttgccactt tcatattgca gccagcatca acccagccac agacattcca cttcttccat   1200

ctattacatc tctgagtcta aatgaaaatg aagagaagac cggacctttt gttgtacact   1260

ggctaaacaa taaagaactg cattttactt tgtccatgga agttttttta cagcaactta   1320

gaaaaagttt tgaacaacca tcttctgagg ccagtgtaga agattctaat caggcagatg   1380

taaaatctga tgaagaaact gatgatggtg ttgatgatct gaaaataaat cccgaaaaga   1440

aggaattagg ctgtgataaa atggtaccaa actcaagttt tacatcatta tcgtcagctg   1500

ccattgatca tcagattgaa gtacttctgt ctgaatggag taaaaatgca gatatgctat   1560

ttagtattca tcccatggat ggttctttgc tagtttggca tgtggattgg ctggatgaat   1620

accagcctgg tatgtttcgt caagtacagg tgtcctttgt ttccagaatt ccagtagctt   1680

tccccacagg tgatgcaaac tctctctgta aaagcataat gatgtatgcc tgtaccaaga   1740

atgttgactt ggctattcag caggggaaac aaaaaccttc tggcctcacc cgttccacat   1800

caatgcttat ttcttctggt cacaataaat catctaatag tttaaaatta agtattttta   1860

cgcctaatgt tatgatgata tcaaaacatg ctgatggttc tctgaatcag tggctggtca   1920

gttttgccga ggaatctgct ttttctactg ttctcagtat ttcccacaaa tccagatatt   1980

gtggtcatcg ttttcatctt aatgatttag cttgccactc agtattacca ttattgctga   2040

caacatcaca ccataatgca ttaaggacac cagatgttga taacccagag caaccttttg   2100

atgctctaaa tattgaagaa tgctctttga cacaacaaaa taaaagcact gttgacgtgg   2160

catttcagga tcccagtgca gtttacagtg agcttattct gtggagggtt gacccagttg   2220

ggccattgtc tttttctgga ggagtttctg agcttgcccg gattaattct cttcatgttt   2280

ctgccttttc caatgtggca tggctgccca ctcttatacc cagttattgt ctgggtgcat   2340

actgcaactc tcctagtgca tgctttgtag ccagtgatgg acaatatctg agattatatg   2400

aagcagttat tgatgctaag aaacttttat ctgagctttc taaccctgaa atttctaaat   2460

atgttggtga agtctttaac atcgtcagtc aacaatcaac agccaggcca ggatgcatta   2520

ttgcattaga tcccattacc aaacttcatg gcagaaaaac ccaactgctt catgtttttg   2580

aagaagactt cattttgaat aaccttgaga agaaaagcct tggcaaagac agcattttat   2640

ctaatgcagg cagctcacct aatggatttt ctgagaagtt ctacctaatt gtaatagaat   2700

gcactcaaga caaccgttca ctgttacaca tgtggaattt acatctaaag tcaattcctg   2760

tctcattaga tgaaaaagta gatacaaaat tatccgaagc ggtttggcag ccagaagaac   2820

attattcttc ttctccagag aagatcctat ctcctttttc acaaaagtat caggcttgca   2880

gagcaaatct ccagagtacc agcaggttga ctctgttttc agaaatggtt tatagccaag   2940

aattgcattt accagaagga gttgagataa taagtattaa gccatcagca ggacatctga   3000

gttcatcttc tatatatcct gcatgcagtg ctccttattt attggcaact tcatgttcag   3060

atgagaaagt aagattctgg agatgcagag taacagatgg agaatctgcc acgtcaaaga   3120

atggaaaaat tgatcttgca tacatttggg aagaatggcc attacttatt gaagatggac   3180

ttcagagcaa tagtagtata actgtacctg gtaggcctgt agaagttagc tgtgcacata   3240

caaatcgttt agcagtagct tataagcagc ctgcatctaa tagtagatct tcccaggact   3300

ttgtgatgca tgtaagtatt tttgaatgtg agtcaacagg aggttcatgt tgggtccttg   3360

agcagacaat tcatttagat gagttaagca cagtattgga ttctggcatt agtgttgata   3420

gcaatttagt ggcctataat aaacaagaca tgtatttatc tagtaaagag aatatcacat   3480

caaacacaaa gcatttagtt cacttagatt ggatgtctag agaagacggt tctcatatcc   3540

tgactgtagg aattggatca aaacttttta tgtatggacc cctggctggc aaggtacaag   3600

accaaactgg taaggaaacc ctggcatttc ctctctggga gagtaccaaa gttgtgcccc   3660

tttctaaatt tgtactatta cgaagtgtgg acctagtttc ttctgtagat ggctccccac   3720

cttttcctgt ttctttatcg tgggtccggg atggcatcct tgtggtagga atggactgtg   3780

aaatgcatgt gtattgccaa tggcaaccat cttctaaaca agaacctgtt ataacagatt   3840

cgtacagtgg gagcactcca tctataacaa gtttaataaa acagagtaac tccagttctg   3900

ggttacatcc tccaaagaaa actctgactc gatccatgac cagtcttgca cagaaaatct   3960

gtggaaagaa aactgcattc gatccttcag tggatatgga agattcaggt ctttttgaag   4020

cagctcatgt actttccccg actctacctc agtatcatcc cttgcagctt ttggaactca   4080

tggatcttgg taaagttcgg agagccaagg ccatcttgtc ccatcttgtt aagtgcattg   4140

ctggggaagt tgtggctctg aatgaagctg aatctaatca tgaacgccgc cttaggtctc   4200

tcacaatcag tgctagtgga agcactacca gagaccccca ggcattcaac aaggctgaaa   4260

atacagatta cacagaaata gattctgttc ctccacttcc tttatatgcc ttacttgcag   4320

cagatgatga tagctgttac tcatctttgg agaaatctag taatgagagt acgttaagta   4380

aatcaaacca attatctaaa gaaagttatg atgagctttt tcagactcaa cttctaatga   4440

ctgatactca tatgttagag acagatgaag aaaatacaaa gcctagagtt attgaccttt   4500

cacagtacag tccgacttac tttggacctg agcatgctca ggttctttct ggccacttac   4560

ttcattctag tttaccagga ctcagccgga tggagcagat gtctttgatg gccttagcag   4620

atacaattgc aactacaagc actgatattg gagaaagccg agacagaagc caaggtggag   4680

aaactcttga tgaatgtggg ttaaaatttc ttttggctgt tcgactccat acctttctta   4740

caacttccct tccagcctat cgagctcaac tccttcacca aggcctgtct acaagtcatt   4800

ttgcttgggc atttcactca gtagcagaag aagaactgct gaacatgttg ccagccatgc   4860

agaaagatga tcccacttgg tctgaactaa gagctatggg tgtggggtgg tgggtccgga   4920

atacccgcat cttacgcaaa tgcatagaaa aagtagctaa agcagccttt tatagaaaga   4980

atgatccttt agatgctgcc attttttacc ttgcaatgaa aaagaaagct gtgatttggg   5040

gattatatag agctgaaaaa aacaccagga tgacacagtt ttttggacac aattttgagg   5100

atgagaggtg gcgtaaagca gctttaaaga atgctttttc tttgctaggc aaacaaagat   5160

ttgaacattc tgcagcattt tttcttttag ctggttgcct cagagatgca attgaggtat   5220

gtcttgagaa attgaatgac attcagttgg ctcttgtaat agcaagactc tatgagtctg   5280

aatttgatac atctgcagca tataaatcta ttttacgtaa aaaagttttg ggaatcgatt   5340

ctcctgtcag tgaactgtgt tcattgaaca taaatatgca tcatgatcct tttcttcgga   5400

gcatggcata ttggattttg gaagattata gtggtgctct ggaaacatta ataaagcaac   5460

ctatcagaga gaatgatgat caagttttat cagccagtaa tcctacagtt tttaatttct   5520

acaattatct aagaacacat cctcttttgc tgagacgtca ttttggatca tctgatacat   5580

tttccacaca tatgagccta acaggaaaaa gtggactggc aggaacaatt aatttaagtg   5640

aaagacgttt attttttacc actgccagtg ctcatttaaa agctggctgc ccaatgttgg   5700

ctttggaagt attatcaaag atgcctaaag tcatcaagaa aacaagacct ttttataggg   5760

cttctagttt tctggatact agtaaagact gttctccttc ttctccatta aagttggatg   5820

caagggaaga taagtcttct gctgttgatt ggtcacagtc actgataaat ggttttggat   5880

cttcttcaga gggttcctca gagaagcaat caaactccac tctttctttt gactggagcc   5940

aaccaagtgt tgtgtttcag gatgactctt tagagttaaa atgggacagt gataatgatg   6000

aagaaaatga ggatgtccct atttcaatga aagaactaaa acctttacag agaaaaacag   6060

ataaaaagtt ggatgacata agttctaact acacagaatc tttcagcaca ctagatgaaa   6120

atgacctttt aaatccatca gaagatataa ttgcagttca gttaaaattt agagcatgtt   6180

taaagattct cacagtagaa cttcgtactt tatctactgg ctatgaaata gatggtggaa   6240

aattgcgtta ccaactatac cactggcttg aaaaagaggt gatagctctt cagaggactt   6300

gtgacttttg ctcagatgct gaagaactac agtctgcatt tggcagaaat gaagatgaat   6360

ttggattaaa tgaggatgct gaagatttgc ctcaccaaac aaaagtgaaa caactgagag   6420

aaaattttca ggaaaaaaga cagtggctct tgaagtatca gtcacttttg agaatgtttc   6480

ttagttactg catacttcat ggatcccatg gtgggggtct tgcatctgta agaatggaat   6540

tgattttgct tttgcaagaa tctcagcagg aaacatcaga accactattt tctagccttc   6600

tgtcagagca aacctcagtg cctctcctct ttgcttgtac agccaatgcc aaaacagtag   6660

ttgccaatcc attattgcac cttagtaatc tgacacatga tattctccat gccataataa   6720

actttgattc accaccccac cctgatatcc aaagcaataa agtgtatgta atgcatactt   6780

tagcagcttc actttctgct tgtatttatc agtgcctttg tggtagtcat aactacagtt   6840

catttcagac gaatcagttt actggaatgg tatatcagac agtactgctt cctcatcgac   6900

cttctttgaa aacaggaagc ttagatgaag cattaactcc caatacgtca ccagctcaat   6960

ggccaggaat aacttgtcta attcgacttt tgaattcttc tggcgaggaa gcccagtcag   7020

ggcttacagt cttgctctgt gagattctca cagcagtgta tcttagtctc ttcatccatg   7080

gcctggccac acattcaagt aatgagctat ttcggattgt ggcccatcct ctaaatgaga   7140

aaatgtggtc tgctgtgttt ggtggaggtg cacatgttcc tagcaaagaa cagacacatt   7200

caaaaacttt acctgtttct tcactagttg aagaaggaga aaaacagaac aaacgtttta   7260

ggccgtcaaa aatgtcttgc agagaatctg ccccactgac cccttcctcg gcaccagtaa   7320

gccaggagtc actggcggtt aaagaaaagt tcatcccacc tgagctcagt atctgggact   7380

atttcatagc taagcctttt ctaccctctt ctcaaagtag agccgaatat gattcagagg   7440

agagtctggg aagtgatgat gatgacaatg atgatgatga tgatgtttta gcatcagatt   7500

tccatctcca ggaacattct aattcaaatt catatagttg gtccttgatg cggttggcga   7560

tggtgcaatt ggtgctcaac aatttgaaga ctttttatcc cttcgcaggt catgatcttg   7620

cagagcttcc agttagttca cctctttgtc atgcggttct aaaaactctt caatgttggg   7680

aacaagttct tctccgacga cttgaaatcc atggtgggcc acctcaaaat tatatcgcaa   7740

gtcataccgc cgaagagagt ttgtctgcag gtcctgcaat tcttcgccac aaagctttac   7800

tggaacctac aaacactcct ttcaaatcca aacaccatct ggcactgtct gtgaagaggc   7860

tttggcagta tttggtgaag caggaagaaa ttcaggaaac ctttatcaaa aatatattca   7920

caaagaaacg gtgtctaaat gagatagaag cagatttggg atatcctgga ggtaaagcaa   7980

gaattattca taaggaatct gatatcatta ctgcgtttgc tgttaataag gcaaatagaa   8040

actgcatagc aatcgcttcc agtcatgatg ttcaagaact ggatgtttct ggaattctgg   8100

ccacacaggt ctacacttgg gtagatgatg atatagaagt ggaaaccaaa ggatcagaag   8160

atttcttggt tatacatgct cgtgatgatt ta                                 8192


<210>  1092
<211>  3027
<212>  PRT
<213>  Homosapiens

<400>  1092

Met Asn Leu His Gln Val Leu Thr Gly Ala Val Asn Pro Gly Asp His 
1               5                   10                  15      


Cys Phe Ser Val Gly Ser Ile Gly Asp Gln Arg Phe Thr Ala Tyr Ala 
            20                  25                  30          


Ser Gly Cys Asp Ile Val Ile Leu Gly Ser Asp Phe Glu Arg Leu Gln 
        35                  40                  45              


Ile Ile Pro Gly Ala Lys His Gly Asn Ile Gln Val Gly Cys Val Asp 
    50                  55                  60                  


Cys Ser Met Gln Gln Gly Lys Ile Ala Ala Ser Tyr Gly Asn Val Ile 
65                  70                  75                  80  


Ser Ile Phe Glu Pro Val Asn Leu Pro Lys Gln Lys Lys Asn Leu Glu 
                85                  90                  95      


Leu Tyr Ser Gln Trp Gln Lys Ser Gly Gln Phe Phe Leu Glu Ser Ile 
            100                 105                 110         


Ala His Asn Ile Thr Trp Asp Pro Thr Gly Ser Arg Leu Leu Thr Gly 
        115                 120                 125             


Ser Ser Tyr Leu Gln Leu Trp Ser Asn Thr Asn Leu Glu Lys Pro Thr 
    130                 135                 140                 


Glu Asp Glu Asn Leu Asn Lys Thr Asp Leu Asn Phe Gly Asp Trp Lys 
145                 150                 155                 160 


Cys Ile Trp His Cys Lys Thr Ala Ser Gln Val His Leu Met Lys Phe 
                165                 170                 175     


Ser Pro Asp Gly Glu Phe Phe Ala Thr Ala Gly Lys Asp Asp Cys Leu 
            180                 185                 190         


Leu Lys Val Trp Tyr Asn Val Glu Asn Trp Arg Thr Ala Val Thr Ser 
        195                 200                 205             


Pro Asp Gly Ser Ser Glu Lys Gln Ser Gln Gly Glu Ile Asp Phe Ser 
    210                 215                 220                 


Phe Val Tyr Leu Ala His Pro Arg Ala Val Asn Gly Phe Ser Trp Arg 
225                 230                 235                 240 


Lys Thr Ser Lys Tyr Met Pro Arg Ala Ser Val Cys Asn Val Leu Leu 
                245                 250                 255     


Thr Cys Cys Lys Asp Asn Val Cys Arg Leu Trp Val Glu Thr Phe Leu 
            260                 265                 270         


Pro Asn Asp Cys Leu Leu Tyr Gly Gly Asp Cys Ser His Trp Thr Glu 
        275                 280                 285             


Ser Ile Asn Leu Thr Asn Asn Phe Lys Arg Asn Ala Ser Ser Lys Glu 
    290                 295                 300                 


Arg Val Gln Asn Ala Leu Glu Val Asn Leu Arg His Phe Arg Arg Gly 
305                 310                 315                 320 


Arg Arg Arg Ser Leu Ala Leu Val Ala His Thr Gly Tyr Leu Pro His 
                325                 330                 335     


Gln Gln Asp Pro His His Val His Arg Asn Thr Pro Leu His Ala Asn 
            340                 345                 350         


Ala Leu Cys His Phe His Ile Ala Ala Ser Ile Asn Pro Ala Thr Asp 
        355                 360                 365             


Ile Pro Leu Leu Pro Ser Ile Thr Ser Leu Ser Leu Asn Glu Asn Glu 
    370                 375                 380                 


Glu Lys Thr Gly Pro Phe Val Val His Trp Leu Asn Asn Lys Glu Leu 
385                 390                 395                 400 


His Phe Thr Leu Ser Met Glu Val Phe Leu Gln Gln Leu Arg Lys Ser 
                405                 410                 415     


Phe Glu Gln Pro Ser Ser Glu Ala Ser Val Glu Asp Ser Asn Gln Ala 
            420                 425                 430         


Asp Val Lys Ser Asp Glu Glu Thr Asp Asp Gly Val Asp Asp Leu Lys 
        435                 440                 445             


Ile Asn Pro Glu Lys Lys Glu Leu Gly Cys Asp Lys Met Val Pro Asn 
    450                 455                 460                 


Ser Ser Phe Thr Ser Leu Ser Ser Ala Ala Ile Asp His Gln Ile Glu 
465                 470                 475                 480 


Val Leu Leu Ser Glu Trp Ser Lys Asn Ala Asp Met Leu Phe Ser Ile 
                485                 490                 495     


His Pro Met Asp Gly Ser Leu Leu Val Trp His Val Asp Trp Leu Asp 
            500                 505                 510         


Glu Tyr Gln Pro Gly Met Phe Arg Gln Val Gln Val Ser Phe Val Ser 
        515                 520                 525             


Arg Ile Pro Val Ala Phe Pro Thr Gly Asp Ala Asn Ser Leu Cys Lys 
    530                 535                 540                 


Ser Ile Met Met Tyr Ala Cys Thr Lys Asn Val Asp Leu Ala Ile Gln 
545                 550                 555                 560 


Gln Gly Lys Gln Lys Pro Ser Gly Leu Thr Arg Ser Thr Ser Met Leu 
                565                 570                 575     


Ile Ser Ser Gly His Asn Lys Ser Ser Asn Ser Leu Lys Leu Ser Ile 
            580                 585                 590         


Phe Thr Pro Asn Val Met Met Ile Ser Lys His Ala Asp Gly Ser Leu 
        595                 600                 605             


Asn Gln Trp Leu Val Ser Phe Ala Glu Glu Ser Ala Phe Ser Thr Val 
    610                 615                 620                 


Leu Ser Ile Ser His Lys Ser Arg Tyr Cys Gly His Arg Phe His Leu 
625                 630                 635                 640 


Asn Asp Leu Ala Cys His Ser Val Leu Pro Leu Leu Leu Thr Thr Ser 
                645                 650                 655     


His His Asn Ala Leu Arg Thr Pro Asp Val Asp Asn Pro Glu Gln Pro 
            660                 665                 670         


Phe Asp Ala Leu Asn Ile Glu Glu Cys Ser Leu Thr Gln Gln Asn Lys 
        675                 680                 685             


Ser Thr Val Asp Val Ala Phe Gln Asp Pro Ser Ala Val Tyr Ser Glu 
    690                 695                 700                 


Leu Ile Leu Trp Arg Val Asp Pro Val Gly Pro Leu Ser Phe Ser Gly 
705                 710                 715                 720 


Gly Val Ser Glu Leu Ala Arg Ile Asn Ser Leu His Val Ser Ala Phe 
                725                 730                 735     


Ser Asn Val Ala Trp Leu Pro Thr Leu Ile Pro Ser Tyr Cys Leu Gly 
            740                 745                 750         


Ala Tyr Cys Asn Ser Pro Ser Ala Cys Phe Val Ala Ser Asp Gly Gln 
        755                 760                 765             


Tyr Leu Arg Leu Tyr Glu Ala Val Ile Asp Ala Lys Lys Leu Leu Ser 
    770                 775                 780                 


Glu Leu Ser Asn Pro Glu Ile Ser Lys Tyr Val Gly Glu Val Phe Asn 
785                 790                 795                 800 


Ile Val Ser Gln Gln Ser Thr Ala Arg Pro Gly Cys Ile Ile Ala Leu 
                805                 810                 815     


Asp Pro Ile Thr Lys Leu His Gly Arg Lys Thr Gln Leu Leu His Val 
            820                 825                 830         


Phe Glu Glu Asp Phe Ile Leu Asn Asn Leu Glu Lys Lys Ser Leu Gly 
        835                 840                 845             


Lys Asp Ser Ile Leu Ser Asn Ala Gly Ser Ser Pro Asn Gly Phe Ser 
    850                 855                 860                 


Glu Lys Phe Tyr Leu Ile Val Ile Glu Cys Thr Gln Asp Asn Arg Ser 
865                 870                 875                 880 


Leu Leu His Met Trp Asn Leu His Leu Lys Ser Ile Pro Val Ser Leu 
                885                 890                 895     


Asp Glu Lys Val Asp Thr Lys Leu Ser Glu Ala Val Trp Gln Pro Glu 
            900                 905                 910         


Glu His Tyr Ser Ser Ser Pro Glu Lys Ile Leu Ser Pro Phe Ser Gln 
        915                 920                 925             


Lys Tyr Gln Ala Cys Arg Ala Asn Leu Gln Ser Thr Ser Arg Leu Thr 
    930                 935                 940                 


Leu Phe Ser Glu Met Val Tyr Ser Gln Glu Leu His Leu Pro Glu Gly 
945                 950                 955                 960 


Val Glu Ile Ile Ser Ile Lys Pro Ser Ala Gly His Leu Ser Ser Ser 
                965                 970                 975     


Ser Ile Tyr Pro Ala Cys Ser Ala Pro Tyr Leu Leu Ala Thr Ser Cys 
            980                 985                 990         


Ser Asp Glu Lys Val Arg Phe Trp  Arg Cys Arg Val Thr  Asp Gly Glu 
        995                 1000                 1005             


Ser Ala  Thr Ser Lys Asn Gly  Lys Ile Asp Leu Ala  Tyr Ile Trp 
    1010                 1015                 1020             


Glu Glu  Trp Pro Leu Leu Ile  Glu Asp Gly Leu Gln  Ser Asn Ser 
    1025                 1030                 1035             


Ser Ile  Thr Val Pro Gly Arg  Pro Val Glu Val Ser  Cys Ala His 
    1040                 1045                 1050             


Thr Asn  Arg Leu Ala Val Ala  Tyr Lys Gln Pro Ala  Ser Asn Ser 
    1055                 1060                 1065             


Arg Ser  Ser Gln Asp Phe Val  Met His Val Ser Ile  Phe Glu Cys 
    1070                 1075                 1080             


Glu Ser  Thr Gly Gly Ser Cys  Trp Val Leu Glu Gln  Thr Ile His 
    1085                 1090                 1095             


Leu Asp  Glu Leu Ser Thr Val  Leu Asp Ser Gly Ile  Ser Val Asp 
    1100                 1105                 1110             


Ser Asn  Leu Val Ala Tyr Asn  Lys Gln Asp Met Tyr  Leu Ser Ser 
    1115                 1120                 1125             


Lys Glu  Asn Ile Thr Ser Asn  Thr Lys His Leu Val  His Leu Asp 
    1130                 1135                 1140             


Trp Met  Ser Arg Glu Asp Gly  Ser His Ile Leu Thr  Val Gly Ile 
    1145                 1150                 1155             


Gly Ser  Lys Leu Phe Met Tyr  Gly Pro Leu Ala Gly  Lys Val Gln 
    1160                 1165                 1170             


Asp Gln  Thr Gly Lys Glu Thr  Leu Ala Phe Pro Leu  Trp Glu Ser 
    1175                 1180                 1185             


Thr Lys  Val Val Pro Leu Ser  Lys Phe Val Leu Leu  Arg Ser Val 
    1190                 1195                 1200             


Asp Leu  Val Ser Ser Val Asp  Gly Ser Pro Pro Phe  Pro Val Ser 
    1205                 1210                 1215             


Leu Ser  Trp Val Arg Asp Gly  Ile Leu Val Val Gly  Met Asp Cys 
    1220                 1225                 1230             


Glu Met  His Val Tyr Cys Gln  Trp Gln Pro Ser Ser  Lys Gln Glu 
    1235                 1240                 1245             


Pro Val  Ile Thr Asp Ser Tyr  Ser Gly Ser Thr Pro  Ser Ile Thr 
    1250                 1255                 1260             


Ser Leu  Ile Lys Gln Ser Asn  Ser Ser Ser Gly Leu  His Pro Pro 
    1265                 1270                 1275             


Lys Lys  Thr Leu Thr Arg Ser  Met Thr Ser Leu Ala  Gln Lys Ile 
    1280                 1285                 1290             


Cys Gly  Lys Lys Thr Ala Phe  Asp Pro Ser Val Asp  Met Glu Asp 
    1295                 1300                 1305             


Ser Gly  Leu Phe Glu Ala Ala  His Val Leu Ser Pro  Thr Leu Pro 
    1310                 1315                 1320             


Gln Tyr  His Pro Leu Gln Leu  Leu Glu Leu Met Asp  Leu Gly Lys 
    1325                 1330                 1335             


Val Arg  Arg Ala Lys Ala Ile  Leu Ser His Leu Val  Lys Cys Ile 
    1340                 1345                 1350             


Ala Gly  Glu Val Val Ala Leu  Asn Glu Ala Glu Ser  Asn His Glu 
    1355                 1360                 1365             


Arg Arg  Leu Arg Ser Leu Thr  Ile Ser Ala Ser Gly  Ser Thr Thr 
    1370                 1375                 1380             


Arg Asp  Pro Gln Ala Phe Asn  Lys Ala Glu Asn Thr  Asp Tyr Thr 
    1385                 1390                 1395             


Glu Ile  Asp Ser Val Pro Pro  Leu Pro Leu Tyr Ala  Leu Leu Ala 
    1400                 1405                 1410             


Ala Asp  Asp Asp Ser Cys Tyr  Ser Ser Leu Glu Lys  Ser Ser Asn 
    1415                 1420                 1425             


Glu Ser  Thr Leu Ser Lys Ser  Asn Gln Leu Ser Lys  Glu Ser Tyr 
    1430                 1435                 1440             


Asp Glu  Leu Phe Gln Thr Gln  Leu Leu Met Thr Asp  Thr His Met 
    1445                 1450                 1455             


Leu Glu  Thr Asp Glu Glu Asn  Thr Lys Pro Arg Val  Ile Asp Leu 
    1460                 1465                 1470             


Ser Gln  Tyr Ser Pro Thr Tyr  Phe Gly Pro Glu His  Ala Gln Val 
    1475                 1480                 1485             


Leu Ser  Gly His Leu Leu His  Ser Ser Leu Pro Gly  Leu Ser Arg 
    1490                 1495                 1500             


Met Glu  Gln Met Ser Leu Met  Ala Leu Ala Asp Thr  Ile Ala Thr 
    1505                 1510                 1515             


Thr Ser  Thr Asp Ile Gly Glu  Ser Arg Asp Arg Ser  Gln Gly Gly 
    1520                 1525                 1530             


Glu Thr  Leu Asp Glu Cys Gly  Leu Lys Phe Leu Leu  Ala Val Arg 
    1535                 1540                 1545             


Leu His  Thr Phe Leu Thr Thr  Ser Leu Pro Ala Tyr  Arg Ala Gln 
    1550                 1555                 1560             


Leu Leu  His Gln Gly Leu Ser  Thr Ser His Phe Ala  Trp Ala Phe 
    1565                 1570                 1575             


His Ser  Val Ala Glu Glu Glu  Leu Leu Asn Met Leu  Pro Ala Met 
    1580                 1585                 1590             


Gln Lys  Asp Asp Pro Thr Trp  Ser Glu Leu Arg Ala  Met Gly Val 
    1595                 1600                 1605             


Gly Trp  Trp Val Arg Asn Thr  Arg Ile Leu Arg Lys  Cys Ile Glu 
    1610                 1615                 1620             


Lys Val  Ala Lys Ala Ala Phe  Tyr Arg Lys Asn Asp  Pro Leu Asp 
    1625                 1630                 1635             


Ala Ala  Ile Phe Tyr Leu Ala  Met Lys Lys Lys Ala  Val Ile Trp 
    1640                 1645                 1650             


Gly Leu  Tyr Arg Ala Glu Lys  Asn Thr Arg Met Thr  Gln Phe Phe 
    1655                 1660                 1665             


Gly His  Asn Phe Glu Asp Glu  Arg Trp Arg Lys Ala  Ala Leu Lys 
    1670                 1675                 1680             


Asn Ala  Phe Ser Leu Leu Gly  Lys Gln Arg Phe Glu  His Ser Ala 
    1685                 1690                 1695             


Ala Phe  Phe Leu Leu Ala Gly  Cys Leu Arg Asp Ala  Ile Glu Val 
    1700                 1705                 1710             


Cys Leu  Glu Lys Leu Asn Asp  Ile Gln Leu Ala Leu  Val Ile Ala 
    1715                 1720                 1725             


Arg Leu  Tyr Glu Ser Glu Phe  Asp Thr Ser Ala Ala  Tyr Lys Ser 
    1730                 1735                 1740             


Ile Leu  Arg Lys Lys Val Leu  Gly Ile Asp Ser Pro  Val Ser Glu 
    1745                 1750                 1755             


Leu Cys  Ser Leu Asn Ile Asn  Met His His Asp Pro  Phe Leu Arg 
    1760                 1765                 1770             


Ser Met  Ala Tyr Trp Ile Leu  Glu Asp Tyr Ser Gly  Ala Leu Glu 
    1775                 1780                 1785             


Thr Leu  Ile Lys Gln Pro Ile  Arg Glu Asn Asp Asp  Gln Val Leu 
    1790                 1795                 1800             


Ser Ala  Ser Asn Pro Thr Val  Phe Asn Phe Tyr Asn  Tyr Leu Arg 
    1805                 1810                 1815             


Thr His  Pro Leu Leu Leu Arg  Arg His Phe Gly Ser  Ser Asp Thr 
    1820                 1825                 1830             


Phe Ser  Thr His Met Ser Leu  Thr Gly Lys Ser Gly  Leu Ala Gly 
    1835                 1840                 1845             


Thr Ile  Asn Leu Ser Glu Arg  Arg Leu Phe Phe Thr  Thr Ala Ser 
    1850                 1855                 1860             


Ala His  Leu Lys Ala Gly Cys  Pro Met Leu Ala Leu  Glu Val Leu 
    1865                 1870                 1875             


Ser Lys  Met Pro Lys Val Ile  Lys Lys Thr Arg Pro  Phe Tyr Arg 
    1880                 1885                 1890             


Ala Ser  Ser Phe Leu Asp Thr  Ser Lys Asp Cys Ser  Pro Ser Ser 
    1895                 1900                 1905             


Pro Leu  Lys Leu Asp Ala Arg  Glu Asp Lys Ser Ser  Ala Val Asp 
    1910                 1915                 1920             


Trp Ser  Gln Ser Leu Ile Asn  Gly Phe Gly Ser Ser  Ser Glu Gly 
    1925                 1930                 1935             


Ser Ser  Glu Lys Gln Ser Asn  Ser Thr Leu Ser Phe  Asp Trp Ser 
    1940                 1945                 1950             


Gln Pro  Ser Val Val Phe Gln  Asp Asp Ser Leu Glu  Leu Lys Trp 
    1955                 1960                 1965             


Asp Ser  Asp Asn Asp Glu Glu  Asn Glu Asp Val Pro  Ile Ser Met 
    1970                 1975                 1980             


Lys Glu  Leu Lys Pro Leu Gln  Arg Lys Thr Asp Lys  Lys Leu Asp 
    1985                 1990                 1995             


Asp Ile  Ser Ser Asn Tyr Thr  Glu Ser Phe Ser Thr  Leu Asp Glu 
    2000                 2005                 2010             


Asn Asp  Leu Leu Asn Pro Ser  Glu Asp Ile Ile Ala  Val Gln Leu 
    2015                 2020                 2025             


Lys Phe  Arg Ala Cys Leu Lys  Ile Leu Thr Val Glu  Leu Arg Thr 
    2030                 2035                 2040             


Leu Ser  Thr Gly Tyr Glu Ile  Asp Gly Gly Lys Leu  Arg Tyr Gln 
    2045                 2050                 2055             


Leu Tyr  His Trp Leu Glu Lys  Glu Val Ile Ala Leu  Gln Arg Thr 
    2060                 2065                 2070             


Cys Asp  Phe Cys Ser Asp Ala  Glu Glu Leu Gln Ser  Ala Phe Gly 
    2075                 2080                 2085             


Arg Asn  Glu Asp Glu Phe Gly  Leu Asn Glu Asp Ala  Glu Asp Leu 
    2090                 2095                 2100             


Pro His  Gln Thr Lys Val Lys  Gln Leu Arg Glu Asn  Phe Gln Glu 
    2105                 2110                 2115             


Lys Arg  Gln Trp Leu Leu Lys  Tyr Gln Ser Leu Leu  Arg Met Phe 
    2120                 2125                 2130             


Leu Ser  Tyr Cys Ile Leu His  Gly Ser His Gly Gly  Gly Leu Ala 
    2135                 2140                 2145             


Ser Val  Arg Met Glu Leu Ile  Leu Leu Leu Gln Glu  Ser Gln Gln 
    2150                 2155                 2160             


Glu Thr  Ser Glu Pro Leu Phe  Ser Ser Leu Leu Ser  Glu Gln Thr 
    2165                 2170                 2175             


Ser Val  Pro Leu Leu Phe Ala  Cys Thr Ala Asn Ala  Lys Thr Val 
    2180                 2185                 2190             


Val Ala  Asn Pro Leu Leu His  Leu Ser Asn Leu Thr  His Asp Ile 
    2195                 2200                 2205             


Leu His  Ala Ile Ile Asn Phe  Asp Ser Pro Pro His  Pro Asp Ile 
    2210                 2215                 2220             


Gln Ser  Asn Lys Val Tyr Val  Met His Thr Leu Ala  Ala Ser Leu 
    2225                 2230                 2235             


Ser Ala  Cys Ile Tyr Gln Cys  Leu Cys Gly Ser His  Asn Tyr Ser 
    2240                 2245                 2250             


Ser Phe  Gln Thr Asn Gln Phe  Thr Gly Met Val Tyr  Gln Thr Val 
    2255                 2260                 2265             


Leu Leu  Pro His Arg Pro Ser  Leu Lys Thr Gly Ser  Leu Asp Glu 
    2270                 2275                 2280             


Ala Leu  Thr Pro Asn Thr Ser  Pro Ala Gln Trp Pro  Gly Ile Thr 
    2285                 2290                 2295             


Cys Leu  Ile Arg Leu Leu Asn  Ser Ser Gly Glu Glu  Ala Gln Ser 
    2300                 2305                 2310             


Gly Leu  Thr Val Leu Leu Cys  Glu Ile Leu Thr Ala  Val Tyr Leu 
    2315                 2320                 2325             


Ser Leu  Phe Ile His Gly Leu  Ala Thr His Ser Ser  Asn Glu Leu 
    2330                 2335                 2340             


Phe Arg  Ile Val Ala His Pro  Leu Asn Glu Lys Met  Trp Ser Ala 
    2345                 2350                 2355             


Val Phe  Gly Gly Gly Ala His  Val Pro Ser Lys Glu  Gln Thr His 
    2360                 2365                 2370             


Ser Lys  Thr Leu Pro Val Ser  Ser Leu Val Glu Glu  Gly Glu Lys 
    2375                 2380                 2385             


Gln Asn  Lys Arg Phe Arg Pro  Ser Lys Met Ser Cys  Arg Glu Ser 
    2390                 2395                 2400             


Ala Pro  Leu Thr Pro Ser Ser  Ala Pro Val Ser Gln  Glu Ser Leu 
    2405                 2410                 2415             


Ala Val  Lys Glu Lys Phe Ile  Pro Pro Glu Leu Ser  Ile Trp Asp 
    2420                 2425                 2430             


Tyr Phe  Ile Ala Lys Pro Phe  Leu Pro Ser Ser Gln  Ser Arg Ala 
    2435                 2440                 2445             


Glu Tyr  Asp Ser Glu Glu Ser  Leu Gly Ser Asp Asp  Asp Asp Asn 
    2450                 2455                 2460             


Asp Asp  Asp Asp Asp Val Leu  Ala Ser Asp Phe His  Leu Gln Glu 
    2465                 2470                 2475             


His Ser  Asn Ser Asn Ser Tyr  Ser Trp Ser Leu Met  Arg Leu Ala 
    2480                 2485                 2490             


Met Val  Gln Leu Val Leu Asn  Asn Leu Lys Thr Phe  Tyr Pro Phe 
    2495                 2500                 2505             


Ala Gly  His Asp Leu Ala Glu  Leu Pro Val Ser Ser  Pro Leu Cys 
    2510                 2515                 2520             


His Ala  Val Leu Lys Thr Leu  Gln Cys Trp Glu Gln  Val Leu Leu 
    2525                 2530                 2535             


Arg Arg  Leu Glu Ile His Gly  Gly Pro Pro Gln Asn  Tyr Ile Ala 
    2540                 2545                 2550             


Ser His  Thr Ala Glu Glu Ser  Leu Ser Ala Gly Pro  Ala Ile Leu 
    2555                 2560                 2565             


Arg His  Lys Ala Leu Leu Glu  Pro Thr Asn Thr Pro  Phe Lys Ser 
    2570                 2575                 2580             


Lys His  His Leu Ala Leu Ser  Val Lys Arg Leu Trp  Gln Tyr Leu 
    2585                 2590                 2595             


Val Lys  Gln Glu Glu Ile Gln  Glu Thr Phe Ile Lys  Asn Ile Phe 
    2600                 2605                 2610             


Thr Lys  Lys Arg Cys Leu Asn  Glu Ile Glu Ala Asp  Leu Gly Tyr 
    2615                 2620                 2625             


Pro Gly  Gly Lys Ala Arg Ile  Ile His Lys Glu Ser  Asp Ile Ile 
    2630                 2635                 2640             


Thr Ala  Phe Ala Val Asn Lys  Ala Asn Arg Asn Cys  Ile Ala Ile 
    2645                 2650                 2655             


Ala Ser  Ser His Asp Val Gln  Glu Leu Asp Val Ser  Gly Ile Leu 
    2660                 2665                 2670             


Ala Thr  Gln Val Tyr Thr Trp  Val Asp Asp Asp Ile  Glu Val Glu 
    2675                 2680                 2685             


Thr Lys  Gly Ser Glu Asp Phe  Leu Val Ile His Ala  Arg Asp Asp 
    2690                 2695                 2700             


Leu Thr  Ala Val Gln Gly Thr  Thr Pro Tyr Thr His  Ser Asn Pro 
    2705                 2710                 2715             


Gly Thr  Pro Ile Asn Met Pro  Trp Leu Gly Ser Thr  Gln Thr Gly 
    2720                 2725                 2730             


Arg Gly  Ala Ser Val Met Ile  Lys Lys Ala Ile Asn  Asn Val Arg 
    2735                 2740                 2745             


Arg Met  Thr Ser His Pro Thr  Leu Pro Tyr Tyr Leu  Thr Gly Ala 
    2750                 2755                 2760             


Gln Asp  Gly Ser Val Arg Met  Phe Glu Trp Gly His  Ser Gln Gln 
    2765                 2770                 2775             


Ile Thr  Cys Phe Arg Ser Gly  Gly Asn Ser Arg Val  Thr Arg Met 
    2780                 2785                 2790             


Arg Phe  Asn Tyr Gln Gly Asn  Lys Phe Gly Ile Val  Asp Ala Asp 
    2795                 2800                 2805             


Gly Tyr  Leu Ser Leu Tyr Gln  Thr Asn Trp Lys Cys  Cys Pro Val 
    2810                 2815                 2820             


Thr Gly  Ser Met Pro Lys Pro  Tyr Leu Thr Trp Gln  Cys His Asn 
    2825                 2830                 2835             


Lys Thr  Ala Asn Asp Phe Val  Phe Val Ser Ser Ser  Ser Leu Ile 
    2840                 2845                 2850             


Ala Thr  Ala Gly Leu Ser Thr  Asp Asn Arg Asn Val  Cys Leu Trp 
    2855                 2860                 2865             


Asp Thr  Leu Val Ala Pro Ala  Asn Ser Leu Val His  Ala Phe Thr 
    2870                 2875                 2880             


Cys His  Asp Ser Gly Ala Thr  Val Leu Ala Tyr Ala  Pro Lys His 
    2885                 2890                 2895             


Gln Leu  Leu Ile Ser Gly Gly  Arg Lys Gly Phe Thr  Tyr Val Phe 
    2900                 2905                 2910             


Asp Leu  Cys Gln Arg Gln Gln  Arg Gln Leu Phe Gln  Ser His Asp 
    2915                 2920                 2925             


Ser Pro  Val Lys Ala Val Ala  Val Asp Pro Thr Glu  Glu Tyr Phe 
    2930                 2935                 2940             


Val Thr  Gly Ser Ala Glu Gly  Asn Ile Lys Ile Trp  Ser Leu Ser 
    2945                 2950                 2955             


Thr Phe  Gly Leu Leu His Thr  Phe Val Ser Glu His  Ala Arg Gln 
    2960                 2965                 2970             


Ser Ile  Phe Arg Asn Ile Gly  Thr Gly Val Met Gln  Ile Glu Thr 
    2975                 2980                 2985             


Gly Pro  Ala Asn His Ile Phe  Ser Cys Gly Ala Asp  Gly Thr Met 
    2990                 2995                 3000             


Lys Met  Arg Ile Leu Pro Asp  Gln Phe Ser Pro Leu  Asn Glu Val 
    3005                 3010                 3015             


Leu Lys  Asn Asp Val Lys Phe  Met Leu 
    3020                 3025         


<210>  1093
<211>  2003
<212>  DNA
<213>  Homosapiens

<400>  1093
gctcgtccga gtacatgtga gcggtaatcg cccctgcagc tggttatcct gacattatgc     60

actccgaagc agaagaatcc aaggaaggcc taggcttaaa cactggcata tatggagaga    120

acagttgcca ctcgactcag agattgagta gacacccaaa gaactgcagt tcttaagcct    180

taggagaagc gagagaaatg gcagtggcca cagatgtctt taattccaaa aacctggccg    240

ttcaggcaca aaagaagatc ttgggtaaaa tggtgtccaa atccatcgcc accaccttaa    300

tagacgacac aagtagtgag gtgctggatg agctctacag agtgaccagg gagtacaccc    360

aaaacaagaa ggaggcagag aagatcatca agaacctcat caagacagtc atcaagctgg    420

ccattcttta taggaataat cagtttaatc aagatgagct agcattgatg gagaaattta    480

agaagaaagt tcatcagctt gctatgaccg tggtcagttt ccatcaggtg gattatacct    540

ttgaccggaa tgtgttatcc aggctgttaa atgaatgcag agagatgctg caccaaatca    600

ttcagcgcca cctcactgcc aagtcacatg gacgggttaa taatgtgttt gatcattttt    660

cagattgtga atttttggct gccttgtata atccttttgg gaattttaaa ccccacttac    720

aaaaactatg tgatggtatc aacaaaatgt tggatgaaga gaacatatga gcacatgagt    780

taagattgtg actgatcatg atttatttga agatggagca ctgctgattt atgaaggaaa    840

aaagaagaat tttctaaaga ttacacatat ttcagaaaga ctttacccaa ttcagttgtc    900

agacataatg atttatttga aggcttgttt tatttgaaga aaagcatatt gccaaaaatt    960

ctggttaaaa gcttcctaac gggtaacaga ccatgggaga gatatgtggt tgggtaatgc   1020

aaatgtagtt atacaaagaa aaatacagat gtctccagac ctgaggactt tttaataggg   1080

cagttgttgt gttggtggca cattggatat ttctaacatg tacaaagcta tgtattttga   1140

tttactttca tttcttgcta tgtatatgta cttttcttaa aatgccaaga actttctctt   1200

gctatcattg ctccttttga aacaattcaa ttttcatgtc tacagctgac tgttttgtta   1260

agattgagtc atcgacattc aggatttaag tctgaggtag tcaaccctca ggaaaaaaaa   1320

atggcttatc tgaaatcagt actgtggaaa tgaactatat tagctattat gaataatgtc   1380

cagtataaga atatgcttct ggaattgagt tctcctttta agtaccaatg atacttaaat   1440

ttctcagaaa tgtaatggtg tgtcattgcc ttgaaatgct tgcttagggc ttcttttatg   1500

ttatcttaaa aagtgctggt gaattttcca ttttttacat ccatttcaca tgtaagagac   1560

acaaaagtct agattggtct tgatattgag ataataaaaa gtaagtagca ttaagaaagg   1620

taacaatctt cattctacag atgaactcat tgaaacaatt taggggaatg aggggcaaaa   1680

ggggagaaat actgctaaag aacatgagca taaaaatgcg tgcgtttcag tgtttaagaa   1740

ggcttgataa agaatgtcac ttttttattt aactgataag atttttgtta ttttttactt   1800

tgataagtaa accaaagaat atttgtattt caagcagttt gtgtggtgtt tctatataat   1860

tttctgtgta taaataataa agtaggcatt tgtttatttt gtaaaaaaga aatgaaaatc   1920

tgctggccag ctatgtcctc taggaaatga cagacccaac caccagcaat aaacatttcc   1980

attgtcaaaa aaaaaaaaaa aaa                                           2003


<210>  1094
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  1094

Met Ala Val Ala Thr Asp Val Phe Asn Ser Lys Asn Leu Ala Val Gln 
1               5                   10                  15      


Ala Gln Lys Lys Ile Leu Gly Lys Met Val Ser Lys Ser Ile Ala Thr 
            20                  25                  30          


Thr Leu Ile Asp Asp Thr Ser Ser Glu Val Leu Asp Glu Leu Tyr Arg 
        35                  40                  45              


Val Thr Arg Glu Tyr Thr Gln Asn Lys Lys Glu Ala Glu Lys Ile Ile 
    50                  55                  60                  


Lys Asn Leu Ile Lys Thr Val Ile Lys Leu Ala Ile Leu Tyr Arg Asn 
65                  70                  75                  80  


Asn Gln Phe Asn Gln Asp Glu Leu Ala Leu Met Glu Lys Phe Lys Lys 
                85                  90                  95      


Lys Val His Gln Leu Ala Met Thr Val Val Ser Phe His Gln Val Asp 
            100                 105                 110         


Tyr Thr Phe Asp Arg Asn Val Leu Ser Arg Leu Leu Asn Glu Cys Arg 
        115                 120                 125             


Glu Met Leu His Gln Ile Ile Gln Arg His Leu Thr Ala Lys Ser His 
    130                 135                 140                 


Gly Arg Val Asn Asn Val Phe Asp His Phe Ser Asp Cys Glu Phe Leu 
145                 150                 155                 160 


Ala Ala Leu Tyr Asn Pro Phe Gly Asn Phe Lys Pro His Leu Gln Lys 
                165                 170                 175     


Leu Cys Asp Gly Ile Asn Lys Met Leu Asp Glu Glu Asn Ile 
            180                 185                 190 


<210>  1095
<211>  2593
<212>  DNA
<213>  Homosapiens

<400>  1095
ggccagcgcg tctgcttgtt cgtgtgtgtg tcgttgcagg ccttattcat gggctcaccg     60

ctgaggttcg acgggcgggt ggtactggtc accggcgcgg gggcaggatt gggccgagcc    120

tatgccctgg cttttgcaga aagaggagcg ttagttgttg tgaatgattt gggaggggac    180

ttcaaaggag ttggtaaagg ctccttagct gctgataagg ttgttgaaga aataagaagg    240

agaggtggaa aagcagtggc caactatgat tcagtggaag aaggagagaa ggttgtgaag    300

acagccctgg atgcttttgg aagaatagat gttgtggtca acaatgctgg aattctgagg    360

gatcgttcct ttgctaggat aagtgatgaa gactgggata taatccacag agttcatttg    420

cggggttcat tccaagtgac acgggcagca tgggaacaca tgaagaaaca gaagtatgga    480

aggattatta tgacttcatc agcttcagga atatatggca actttggcca ggccaattat    540

agtgctgcaa agttgggtct tctgggcctt gcaaattctc ttgcaattga aggcaggaaa    600

agcaacattc attgtaacac cattgctcct aatgcgggat cacggatgac tcagacagtt    660

atgcctgaag atcttgtgga agccctgaag ccagagtatg tggcacctct tgtcctttgg    720

ctttgtcacg agagttgtga ggagaatggt ggcttgtttg aggttggagc aggatggatt    780

ggaaaattac gctgggagcg gactcttgga gctattgtaa gacaaaagaa tcacccaatg    840

actcctgagg cagtcaaggc taactggaag aagatctgtg actttgagaa tgccagcaag    900

cctcagagta tccaagaatc aactggcagt ataattgaag ttctgagtaa aatagattca    960

gaaggaggag tttcagcaaa tcatactagt cgtgcaacgt ctacagcaac atcaggattt   1020

gctggagcta ttggccagaa actccctcca ttttcttatg cttatacgga actggaagct   1080

attatgtatg cccttggagt gggagcgtca atcaaggatc caaaagattt gaaatttatt   1140

tatgaaggaa gttctgattt ctcctgtttg cccaccttcg gagttatcat aggtcagaaa   1200

tctatgatgg gtggaggatt agcagaaatt cctggacttt caatcaactt tgcaaaggtt   1260

cttcatggag agcagtactt agagttatat aaaccacttc ccagagcagg aaaattaaaa   1320

tgtgaagcag ttgttgctga tgtcctagat aaaggatccg gtgtagtgat tattatggat   1380

gtctattctt attctgagaa ggaacttata tgccacaatc agttctctct ctttcttgtt   1440

ggctctggag gctttggtgg aaaacggaca tcagacaaag tcaaggtagc tgtagccata   1500

cctaatagac ctcctgatgc tgtacttaca gataccacct ctcttaatca ggctgctttg   1560

taccgcctca gtggagactg gaatccctta cacattgatc ctaactttgc tagtctagca   1620

ggttttgaca agcccatatt acatggatta tgtacatttg gattttctgc caggcgtgtg   1680

ttacagcagt ttgcagataa tgatgtgtca agattcaagg caattaaggc tcgttttgca   1740

aaaccagtat atccaggaca aactctacaa actgagatgt ggaaggaagg aaacagaatt   1800

cattttcaaa ccaaggtcca agaaactgga gacattgtca tttcaaatgc atatgtggat   1860

cttgcaccaa catctggtac ttcagctaag acaccctctg agggcgggaa gcttcagagt   1920

acctttgtat ttgaggaaat aggacgccgc ctaaaggata ttgggcctga ggtggtgaag   1980

aaagtaaatg ctgtatttga gtggcatata accaaaggcg gaaatattgg ggctaagtgg   2040

actattgacc tgaaaagtgg ttctggaaaa gtgtaccaag gccctgcaaa aggtgctgct   2100

gatacaacaa tcatactttc agatgaagat ttcatggagg tggtcctggg caagcttgac   2160

cctcagaagg cattctttag tggcaggctg aaggccagag ggaacatcat gctgagccag   2220

aaacttcaga tgattcttaa agactacgcc aagctctgaa gggcacacta cactattaat   2280

aaaaatggaa tcattaaata ctctcttcac ccaaatatgc ttgattattc tgcaaaagtg   2340

attagaacta agatgcaggg gaaattgctt aacattttca gatatcagat aactgcagat   2400

tttcattttc tactaatttt catgtatcat tatttttaca aggaactata tataagctag   2460

cacatgatta tccttctgtt cttagatctg tatcttcata ataaaaaatt ttgcccaagt   2520

cctgtttcct tagaatttgt gatagcattg ataagttgaa aggaaaatta aatcaataaa   2580

ggcctttgat acc                                                      2593


<210>  1096
<211>  736
<212>  PRT
<213>  Homosapiens

<400>  1096

Met Gly Ser Pro Leu Arg Phe Asp Gly Arg Val Val Leu Val Thr Gly 
1               5                   10                  15      


Ala Gly Ala Gly Leu Gly Arg Ala Tyr Ala Leu Ala Phe Ala Glu Arg 
            20                  25                  30          


Gly Ala Leu Val Val Val Asn Asp Leu Gly Gly Asp Phe Lys Gly Val 
        35                  40                  45              


Gly Lys Gly Ser Leu Ala Ala Asp Lys Val Val Glu Glu Ile Arg Arg 
    50                  55                  60                  


Arg Gly Gly Lys Ala Val Ala Asn Tyr Asp Ser Val Glu Glu Gly Glu 
65                  70                  75                  80  


Lys Val Val Lys Thr Ala Leu Asp Ala Phe Gly Arg Ile Asp Val Val 
                85                  90                  95      


Val Asn Asn Ala Gly Ile Leu Arg Asp Arg Ser Phe Ala Arg Ile Ser 
            100                 105                 110         


Asp Glu Asp Trp Asp Ile Ile His Arg Val His Leu Arg Gly Ser Phe 
        115                 120                 125             


Gln Val Thr Arg Ala Ala Trp Glu His Met Lys Lys Gln Lys Tyr Gly 
    130                 135                 140                 


Arg Ile Ile Met Thr Ser Ser Ala Ser Gly Ile Tyr Gly Asn Phe Gly 
145                 150                 155                 160 


Gln Ala Asn Tyr Ser Ala Ala Lys Leu Gly Leu Leu Gly Leu Ala Asn 
                165                 170                 175     


Ser Leu Ala Ile Glu Gly Arg Lys Ser Asn Ile His Cys Asn Thr Ile 
            180                 185                 190         


Ala Pro Asn Ala Gly Ser Arg Met Thr Gln Thr Val Met Pro Glu Asp 
        195                 200                 205             


Leu Val Glu Ala Leu Lys Pro Glu Tyr Val Ala Pro Leu Val Leu Trp 
    210                 215                 220                 


Leu Cys His Glu Ser Cys Glu Glu Asn Gly Gly Leu Phe Glu Val Gly 
225                 230                 235                 240 


Ala Gly Trp Ile Gly Lys Leu Arg Trp Glu Arg Thr Leu Gly Ala Ile 
                245                 250                 255     


Val Arg Gln Lys Asn His Pro Met Thr Pro Glu Ala Val Lys Ala Asn 
            260                 265                 270         


Trp Lys Lys Ile Cys Asp Phe Glu Asn Ala Ser Lys Pro Gln Ser Ile 
        275                 280                 285             


Gln Glu Ser Thr Gly Ser Ile Ile Glu Val Leu Ser Lys Ile Asp Ser 
    290                 295                 300                 


Glu Gly Gly Val Ser Ala Asn His Thr Ser Arg Ala Thr Ser Thr Ala 
305                 310                 315                 320 


Thr Ser Gly Phe Ala Gly Ala Ile Gly Gln Lys Leu Pro Pro Phe Ser 
                325                 330                 335     


Tyr Ala Tyr Thr Glu Leu Glu Ala Ile Met Tyr Ala Leu Gly Val Gly 
            340                 345                 350         


Ala Ser Ile Lys Asp Pro Lys Asp Leu Lys Phe Ile Tyr Glu Gly Ser 
        355                 360                 365             


Ser Asp Phe Ser Cys Leu Pro Thr Phe Gly Val Ile Ile Gly Gln Lys 
    370                 375                 380                 


Ser Met Met Gly Gly Gly Leu Ala Glu Ile Pro Gly Leu Ser Ile Asn 
385                 390                 395                 400 


Phe Ala Lys Val Leu His Gly Glu Gln Tyr Leu Glu Leu Tyr Lys Pro 
                405                 410                 415     


Leu Pro Arg Ala Gly Lys Leu Lys Cys Glu Ala Val Val Ala Asp Val 
            420                 425                 430         


Leu Asp Lys Gly Ser Gly Val Val Ile Ile Met Asp Val Tyr Ser Tyr 
        435                 440                 445             


Ser Glu Lys Glu Leu Ile Cys His Asn Gln Phe Ser Leu Phe Leu Val 
    450                 455                 460                 


Gly Ser Gly Gly Phe Gly Gly Lys Arg Thr Ser Asp Lys Val Lys Val 
465                 470                 475                 480 


Ala Val Ala Ile Pro Asn Arg Pro Pro Asp Ala Val Leu Thr Asp Thr 
                485                 490                 495     


Thr Ser Leu Asn Gln Ala Ala Leu Tyr Arg Leu Ser Gly Asp Trp Asn 
            500                 505                 510         


Pro Leu His Ile Asp Pro Asn Phe Ala Ser Leu Ala Gly Phe Asp Lys 
        515                 520                 525             


Pro Ile Leu His Gly Leu Cys Thr Phe Gly Phe Ser Ala Arg Arg Val 
    530                 535                 540                 


Leu Gln Gln Phe Ala Asp Asn Asp Val Ser Arg Phe Lys Ala Ile Lys 
545                 550                 555                 560 


Ala Arg Phe Ala Lys Pro Val Tyr Pro Gly Gln Thr Leu Gln Thr Glu 
                565                 570                 575     


Met Trp Lys Glu Gly Asn Arg Ile His Phe Gln Thr Lys Val Gln Glu 
            580                 585                 590         


Thr Gly Asp Ile Val Ile Ser Asn Ala Tyr Val Asp Leu Ala Pro Thr 
        595                 600                 605             


Ser Gly Thr Ser Ala Lys Thr Pro Ser Glu Gly Gly Lys Leu Gln Ser 
    610                 615                 620                 


Thr Phe Val Phe Glu Glu Ile Gly Arg Arg Leu Lys Asp Ile Gly Pro 
625                 630                 635                 640 


Glu Val Val Lys Lys Val Asn Ala Val Phe Glu Trp His Ile Thr Lys 
                645                 650                 655     


Gly Gly Asn Ile Gly Ala Lys Trp Thr Ile Asp Leu Lys Ser Gly Ser 
            660                 665                 670         


Gly Lys Val Tyr Gln Gly Pro Ala Lys Gly Ala Ala Asp Thr Thr Ile 
        675                 680                 685             


Ile Leu Ser Asp Glu Asp Phe Met Glu Val Val Leu Gly Lys Leu Asp 
    690                 695                 700                 


Pro Gln Lys Ala Phe Phe Ser Gly Arg Leu Lys Ala Arg Gly Asn Ile 
705                 710                 715                 720 


Met Leu Ser Gln Lys Leu Gln Met Ile Leu Lys Asp Tyr Ala Lys Leu 
                725                 730                 735     


<210>  1097
<211>  1186
<212>  DNA
<213>  Homosapiens

<400>  1097
aaccttaaca gccctgcagt gtagtgggca ctgggcagtg ctgctccttc actaagcggt     60

ctgagttctt tagctatctc ggagattcaa ctacgtttac tcgtactgaa tctttttaat    120

gaatttcctg agagccaaga agggccaatc tacaggaaaa agtgggaggt ggacattaag    180

catcttctag aaactcttct agctgatatc atgaaacgac gacaaaagag gaaacatttg    240

gaaaatgaag agtcccagga aaccgctgag aagggaggag gaatccagag aatacatcga    300

gacagccccc agcctcaatc acccctggcc caggttcagg aacgaggaga gactcctccc    360

cgctcacaac atgtctcctt gtcgtcctat tcatcctata agacttgtgt gtcctctctg    420

tgtgtaaaca aagaggaaag gggcatgaaa atatactaca tgcaggtaca aatgaacaaa    480

ggtgtggctg tctcctggga gacagaggaa actttggagt ccttagaaaa gcagccaagg    540

atggaagaag tgaccctttc tgaggttgtg agggtaggta ctcccccctc tgatgtgtcc    600

accagaaacc tcctgtctga cagtgagccc agtggggagg agaaagagca tgaggaaagg    660

acagaatcag acagcctgcc aggctcaccc accgttgagg acacacccag agccaagact    720

cctgactggc tggtgaccat ggagaacggc ttcaggtgca tggcctgctg ccgggtgttc    780

accaccatgg aagccctcca ggagcatgtg cagtttggga tcagagaggg cttcagctgc    840

cccaagatga gcaggaggag gaaaatggaa atgagaagga ggaggaagag aaaccagaag    900

caaaggagga ggaggggcag cccacagaag aagaccttgg cctgaggaga tcctggagcc    960

aatgtccagg ctgtgtgttt cattctccaa aggacagctg agacttatgg gccagaagat   1020

actggaagat ggtgtggcct tctcttgcaa gagggagaag aaagagccat ggagatagta   1080

gcagacaggc tgcccaaggt atgaagcaga tgagggacca gcactcagtc taacatgtaa   1140

acatcatacg taataaaggt tgtgtttcaa accttaaaaa aaaaaa                  1186


<210>  1098
<211>  244
<212>  PRT
<213>  Homosapiens

<400>  1098

Met Lys Arg Arg Gln Lys Arg Lys His Leu Glu Asn Glu Glu Ser Gln 
1               5                   10                  15      


Glu Thr Ala Glu Lys Gly Gly Gly Ile Gln Arg Ile His Arg Asp Ser 
            20                  25                  30          


Pro Gln Pro Gln Ser Pro Leu Ala Gln Val Gln Glu Arg Gly Glu Thr 
        35                  40                  45              


Pro Pro Arg Ser Gln His Val Ser Leu Ser Ser Tyr Ser Ser Tyr Lys 
    50                  55                  60                  


Thr Cys Val Ser Ser Leu Cys Val Asn Lys Glu Glu Arg Gly Met Lys 
65                  70                  75                  80  


Ile Tyr Tyr Met Gln Val Gln Met Asn Lys Gly Val Ala Val Ser Trp 
                85                  90                  95      


Glu Thr Glu Glu Thr Leu Glu Ser Leu Glu Lys Gln Pro Arg Met Glu 
            100                 105                 110         


Glu Val Thr Leu Ser Glu Val Val Arg Val Gly Thr Pro Pro Ser Asp 
        115                 120                 125             


Val Ser Thr Arg Asn Leu Leu Ser Asp Ser Glu Pro Ser Gly Glu Glu 
    130                 135                 140                 


Lys Glu His Glu Glu Arg Thr Glu Ser Asp Ser Leu Pro Gly Ser Pro 
145                 150                 155                 160 


Thr Val Glu Asp Thr Pro Arg Ala Lys Thr Pro Asp Trp Leu Val Thr 
                165                 170                 175     


Met Glu Asn Gly Phe Arg Cys Met Ala Cys Cys Arg Val Phe Thr Thr 
            180                 185                 190         


Met Glu Ala Leu Gln Glu His Val Gln Phe Gly Ile Arg Glu Gly Phe 
        195                 200                 205             


Ser Cys Pro Lys Met Ser Arg Arg Arg Lys Met Glu Met Arg Arg Arg 
    210                 215                 220                 


Arg Lys Arg Asn Gln Lys Gln Arg Arg Arg Arg Gly Ser Pro Gln Lys 
225                 230                 235                 240 


Lys Thr Leu Ala 
                


<210>  1099
<211>  894
<212>  DNA
<213>  Homosapiens

<400>  1099
ggcggcgcta tgctgtcctg cttcaggctc ctctccaggc acatcagccc ttcgctggcg     60

tctctgcgcc cggtgcgctg ctgcttcgcg ctcccgctgc gttgggcccc ggggcgcccc    120

ttggacccca ggcagatcgc cccccgccgc cccctggccg cagccgcctc ctcccgggac    180

cctaccgggc ccgccgccgg cccctctcgg gtgcgccaga acttccaccc cgactccgag    240

gctgccatca accgccagat caacctcgag ctctatgcgt cctacgtgta cttgtccatg    300

gcctattact tctcccggga tgacgtggcc ttgaacaact tctccaggta tttccttcac    360

cagtcccggg aggagaccga gcacgcggag aagctgatga ggctgcagaa ccagcgagga    420

ggccggatcc gcctgcagga catcaagaag ccggaacagg acgactggga aagcgggctg    480

catgccatgg agtgtgctct actcttggaa aagaacgtga accagtcgtt gctggaattg    540

cacgctctag cctcagataa aggtgacccc catttgtgcg atttcctgga aacctactac    600

ctgaatgagc aggtgaagtc tatcaaagaa ctaggtgacc acgtgcacaa cttagtgaag    660

atgggggccc cggatgctgg cctggcggag tacctttttg acacacatac ccttggaaat    720

gaaaacaagc agaactaagc cacgagctgc cttcctccca ggctagtgga tccaaagacc    780

aaagtcagct gtctcctgct ttcttgccct taaaatcacc tccatcttta tattcttctg    840

ttatactatt cctccaataa agtgatttgt agaaaaaaaa aaaaaaaaaa aaaa          894


<210>  1100
<211>  242
<212>  PRT
<213>  Homosapiens

<400>  1100

Met Leu Ser Cys Phe Arg Leu Leu Ser Arg His Ile Ser Pro Ser Leu 
1               5                   10                  15      


Ala Ser Leu Arg Pro Val Arg Cys Cys Phe Ala Leu Pro Leu Arg Trp 
            20                  25                  30          


Ala Pro Gly Arg Pro Leu Asp Pro Arg Gln Ile Ala Pro Arg Arg Pro 
        35                  40                  45              


Leu Ala Ala Ala Ala Ser Ser Arg Asp Pro Thr Gly Pro Ala Ala Gly 
    50                  55                  60                  


Pro Ser Arg Val Arg Gln Asn Phe His Pro Asp Ser Glu Ala Ala Ile 
65                  70                  75                  80  


Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu Ser 
                85                  90                  95      


Met Ala Tyr Tyr Phe Ser Arg Asp Asp Val Ala Leu Asn Asn Phe Ser 
            100                 105                 110         


Arg Tyr Phe Leu His Gln Ser Arg Glu Glu Thr Glu His Ala Glu Lys 
        115                 120                 125             


Leu Met Arg Leu Gln Asn Gln Arg Gly Gly Arg Ile Arg Leu Gln Asp 
    130                 135                 140                 


Ile Lys Lys Pro Glu Gln Asp Asp Trp Glu Ser Gly Leu His Ala Met 
145                 150                 155                 160 


Glu Cys Ala Leu Leu Leu Glu Lys Asn Val Asn Gln Ser Leu Leu Glu 
                165                 170                 175     


Leu His Ala Leu Ala Ser Asp Lys Gly Asp Pro His Leu Cys Asp Phe 
            180                 185                 190         


Leu Glu Thr Tyr Tyr Leu Asn Glu Gln Val Lys Ser Ile Lys Glu Leu 
        195                 200                 205             


Gly Asp His Val His Asn Leu Val Lys Met Gly Ala Pro Asp Ala Gly 
    210                 215                 220                 


Leu Ala Glu Tyr Leu Phe Asp Thr His Thr Leu Gly Asn Glu Asn Lys 
225                 230                 235                 240 


Gln Asn 
        


<210>  1101
<211>  2836
<212>  DNA
<213>  Homosapiens

<400>  1101
gtggcgacgc agccgcggtc tgagagaccg gttcacgtgc aggcagcggc ggatcatatt     60

ccttcatcta ccatggctca gccgggaact ctgaacctca ataacgaggt tgtgaagatg    120

agaaaagaag tgaagagaat tcgagtttta gttatccgaa aacttgtcag gagtgttggc    180

cgactgaagt caaaaaaggg tactgaagat gcactgttaa aaaaccaaag acgggcgcaa    240

agattgcttg aagaaatcca tgccatgaag gaattgaaac ctgacatagt aactaaatct    300

gctcttggtg atgatatcaa ctttgaaaaa atcttcaaaa agccagattc tactgcaact    360

gaaagagcaa ttgccagact agcagtacat cctcttctga agaaaaagat agatgtgcta    420

aaagctgctg tacaagcctt taaagaagca agacaaaatg ttgctgaagt tgagtcatca    480

aagaatgctt cagaggacaa tcattctgag aatactttgt attcaaatga taatggaagt    540

aatttacagc gtgaagcaac tgtcatcagt gagcaaaaag tcaaagaaac caaaatattg    600

gcgaagaaac caatacataa ttcaaaggaa aaaatagcaa agatggaaca tggacctaaa    660

gcagtgacta ttgcaaattc tccatcaaag ccttcagaaa aggattctgt agtttccctt    720

gagtcccaga agacacctgc tgacccaaaa ctgaaaactc taagtcaaac caaaaaaaac    780

aaaggatctg atagctcact ctctggtaac agtgatggcg gagaagaatt ttgtgaagag    840

gagaaggaat attttgatga tagcacagaa gaaaggtttt acaagcagtc ttccatgtct    900

gaagatagtg atagcggtga cgacttcttc attgggaaag tcagacggac acgaaagaag    960

gaaagtagtt gtcattcttc agttaaggaa caaaaaccac tagaaaaagt gtttcttaaa   1020

gaagatacag gtgaaactca tggggataca agaaatgaca aaatcaagcc aagtacagaa   1080

accagaaagt tagaatcagt gtttttccac tctttatctg gatctaaaag ctctagaaga   1140

aatttcaaag aacaggctcc aaaaacaaga tccctagatt ttccacagaa tgagcctcag   1200

atcaagaatc agtttaataa gaagctatca ggaagacttg aaaatacaaa acagcaattg   1260

cagctgcctc ttcatccttc atgggaagca agcagaaggc gaaaagaaca gcaatctaat   1320

attgctgtgt ttcaggggaa aaaaattacg tttgatgatt gattagtgcc tctttctgca   1380

aacttttcca tctaaaaaaa aaaatgtttt ttttaagaca ggatctcatt ctgttgccca   1440

gactagagta caatattgca atcacagctc actgcagcct caaactcctg ggctcaagtg   1500

atcctcccac ctctgcctcc caaagggctg ggactgcagg tgcatgcact accatgccca   1560

gctttctcac cccaggctct gcagctatta cttaaactcg tatttgaata agtctcttgg   1620

ggagaattat agaatgtttg tttttgtatt tttttttaaa gtaaattcaa cttacgctta   1680

tataagcctt tcacaaatcc aatatgtact taaattgatt tttaataata tccctcagac   1740

tgtttccctt atgaagtaat ttggggattt tagtgatctc atattttctc tttagtgctt   1800

atcatgaaat gtgcttcact ggttcagctc tgttgtttcc ttaaacataa atgtcaatat   1860

atatttaaaa taataatgga aacataggaa atcagctatt taaaccagat cacccttgtt   1920

aaaaatcatt cttgttagca aactaaaata gtaactttta ttatggatgt acagataaat   1980

attaatttta ttatagtttt aagtacttgt gatcatgtac tttttgattc taaaatagtt   2040

gtctaggaca attttgggat tcttaattat attttagtta agaaaattgt ttaaatatag   2100

caatacaacc aataatttgt tttatgtttc actgcatata aatatttcca ttaaatcaag   2160

aatgtatatt atctagtttt tactatactt attttaaaat ttttgaggaa tcatagattc   2220

taatttttaa gaacaaattc tgaaggtggt aggattaaaa gaatatttcc actgatggct   2280

aagcaaagaa gttgtaagat gactcactga ggaagggact gctttataca tcacagtact   2340

gctatttaaa aggaaaacag aaatttttaa atcccttcaa atgtttcact tttgctatgc   2400

tgggaaaaat tttgaagttc ttggtaaact gaataatgct aatccatgtt tcctgcacat   2460

tagttccttt aatggcaggg aaggccatct ggttaacctg tattcacaaa ctctcaagag   2520

tttctactta tttcaggagc ttaagaattt agataactca gccgggcgtg gtgactcatg   2580

cctataatcc cagcactttg ggaggctgag gcgggtagat cgctagaggc aaggagttca   2640

aaaccagcct gggcaacatg gtgaaaccct gtctctacta aaaatacaga aaattatcca   2700

ggcgtggtgg ccggcatctg taattccagc tactcagaag gctgaggcat aagaattgct   2760

tgaacctggg aggtggaggt tgcagtgagc caagattgca ccactgcact ccagcctggg   2820

tgacagagta tgactg                                                   2836


<210>  1102
<211>  429
<212>  PRT
<213>  Homosapiens

<400>  1102

Met Ala Gln Pro Gly Thr Leu Asn Leu Asn Asn Glu Val Val Lys Met 
1               5                   10                  15      


Arg Lys Glu Val Lys Arg Ile Arg Val Leu Val Ile Arg Lys Leu Val 
            20                  25                  30          


Arg Ser Val Gly Arg Leu Lys Ser Lys Lys Gly Thr Glu Asp Ala Leu 
        35                  40                  45              


Leu Lys Asn Gln Arg Arg Ala Gln Arg Leu Leu Glu Glu Ile His Ala 
    50                  55                  60                  


Met Lys Glu Leu Lys Pro Asp Ile Val Thr Lys Ser Ala Leu Gly Asp 
65                  70                  75                  80  


Asp Ile Asn Phe Glu Lys Ile Phe Lys Lys Pro Asp Ser Thr Ala Thr 
                85                  90                  95      


Glu Arg Ala Ile Ala Arg Leu Ala Val His Pro Leu Leu Lys Lys Lys 
            100                 105                 110         


Ile Asp Val Leu Lys Ala Ala Val Gln Ala Phe Lys Glu Ala Arg Gln 
        115                 120                 125             


Asn Val Ala Glu Val Glu Ser Ser Lys Asn Ala Ser Glu Asp Asn His 
    130                 135                 140                 


Ser Glu Asn Thr Leu Tyr Ser Asn Asp Asn Gly Ser Asn Leu Gln Arg 
145                 150                 155                 160 


Glu Ala Thr Val Ile Ser Glu Gln Lys Val Lys Glu Thr Lys Ile Leu 
                165                 170                 175     


Ala Lys Lys Pro Ile His Asn Ser Lys Glu Lys Ile Ala Lys Met Glu 
            180                 185                 190         


His Gly Pro Lys Ala Val Thr Ile Ala Asn Ser Pro Ser Lys Pro Ser 
        195                 200                 205             


Glu Lys Asp Ser Val Val Ser Leu Glu Ser Gln Lys Thr Pro Ala Asp 
    210                 215                 220                 


Pro Lys Leu Lys Thr Leu Ser Gln Thr Lys Lys Asn Lys Gly Ser Asp 
225                 230                 235                 240 


Ser Ser Leu Ser Gly Asn Ser Asp Gly Gly Glu Glu Phe Cys Glu Glu 
                245                 250                 255     


Glu Lys Glu Tyr Phe Asp Asp Ser Thr Glu Glu Arg Phe Tyr Lys Gln 
            260                 265                 270         


Ser Ser Met Ser Glu Asp Ser Asp Ser Gly Asp Asp Phe Phe Ile Gly 
        275                 280                 285             


Lys Val Arg Arg Thr Arg Lys Lys Glu Ser Ser Cys His Ser Ser Val 
    290                 295                 300                 


Lys Glu Gln Lys Pro Leu Glu Lys Val Phe Leu Lys Glu Asp Thr Gly 
305                 310                 315                 320 


Glu Thr His Gly Asp Thr Arg Asn Asp Lys Ile Lys Pro Ser Thr Glu 
                325                 330                 335     


Thr Arg Lys Leu Glu Ser Val Phe Phe His Ser Leu Ser Gly Ser Lys 
            340                 345                 350         


Ser Ser Arg Arg Asn Phe Lys Glu Gln Ala Pro Lys Thr Arg Ser Leu 
        355                 360                 365             


Asp Phe Pro Gln Asn Glu Pro Gln Ile Lys Asn Gln Phe Asn Lys Lys 
    370                 375                 380                 


Leu Ser Gly Arg Leu Glu Asn Thr Lys Gln Gln Leu Gln Leu Pro Leu 
385                 390                 395                 400 


His Pro Ser Trp Glu Ala Ser Arg Arg Arg Lys Glu Gln Gln Ser Asn 
                405                 410                 415     


Ile Ala Val Phe Gln Gly Lys Lys Ile Thr Phe Asp Asp 
            420                 425                 


<210>  1103
<211>  1946
<212>  DNA
<213>  Homosapiens

<400>  1103
agacactgcc cgctctccgg gactccgcgc cgctccccgt tgccttccag gactgagaaa     60

ggggaaaggg aagggtgcca cgtccgagca gccgccttga ctggggaagg gtctgaatcc    120

cacccttggc attgcttggt ggagactgag atacccgtgc tccgctcgcc tccttggttg    180

aagatttctc cttccctcac gtgatttgag ccccgttttt attttctgtg agccacgtcc    240

tcctcgagcg gggtcaatct ggcaaaagga gtgatgcgct tcgcctggac cgtgctcctg    300

ctcgggcctt tgcagctctg cgcgctagtg cactgcgccc ctcccgccgc cggccaacag    360

cagcccccgc gcgagccgcc ggcggctccg ggcgcctggc gccagcagat ccaatgggag    420

aacaacgggc aggtgttcag cttgctgagc ctgggctcac agtaccagcc tcagcgccgc    480

cgggacccgg gcgccgccgt ccctggtgca gccaacgcct ccgcccagca gccccgcact    540

ccgatcctgc tgatccgcga caaccgcacc gccgcggcgc gaacgcggac ggccggctca    600

tctggagtca ccgctggccg ccccaggccc accgcccgtc actggttcca agctggctac    660

tcgacatcta gagcccgcga agctggcgcc tcgcgcgcgg agaaccagac agcgccggga    720

gaagttcctg cgctcagtaa cctgcggccg cccagccgcg tggacggcat ggtgggcgac    780

gacccttaca acccctacaa gtactctgac gacaaccctt attacaacta ctacgatact    840

tatgaaaggc ccagacctgg gggcaggtac cggcccggat acggcactgg ctacttccag    900

tacggtctcc cagacctggt ggccgacccc tactacatcc aggcgtccac gtacgtgcag    960

aagatgtcca tgtacaacct gagatgcgcg gcggaggaaa actgtctggc cagtacagca   1020

tacagggcag atgtcagaga ttatgatcac agggtgctgc tcagatttcc ccaaagagtg   1080

aaaaaccaag ggacatcaga tttcttaccc agccgaccaa gatattcctg ggaatggcac   1140

agttgtcatc aacattacca cagtatggat gagtttagcc actatgacct gcttgatgcc   1200

aacacccaga ggagagtggc tgaaggccac aaagcaagtt tctgtcttga agacacatcc   1260

tgtgactatg gctaccacag gcgatttgca tgtactgcac acacacaggg attgagtcct   1320

ggctgttatg atacctatgg tgcagacata gactgccagt ggattgatat tacagatgta   1380

aaacctggaa actatatcct aaaggtcagt gtaaacccca gctacctggt tcctgaatct   1440

gactatacca acaatgttgt gcgctgtgac attcgctaca caggacatca tgcgtatgcc   1500

tcaggctgca caatttcacc gtattagaag gcaaagcaaa actcccaatg gataaatcag   1560

tgcctggtgt tctgaagtgg gaaaaaatag actaacttca gtaggattta tgtattttga   1620

aaaagagaac agaaaacaac aaaagaattt ttgtttggac tgttttcaat aacaaagcac   1680

ataactggat tttgaacgct taagtcatca ttacttggga aatttttaat gtttattatt   1740

tacatcactt tgtgaattaa cacagtgttt caattctgta attacatatt tgactctttc   1800

aaagaaatcc aaatttctca tgttcctttt gaaattgtag tgcaaaatgg tcagtattat   1860

ctaaatgaat gagccaaaat gactttgaac tgaaactttt ctaaagtgct ggaactttag   1920

tgaaacataa taataatggg tttata                                        1946


<210>  1104
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  1104

Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
1               5                   10                  15      


Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
            20                  25                  30          


Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
        35                  40                  45              


Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
    50                  55                  60                  


Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
65                  70                  75                  80  


Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                85                  90                  95      


Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
            100                 105                 110         


Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
        115                 120                 125             


Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn 
    130                 135                 140                 


Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
145                 150                 155                 160 


Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                165                 170                 175     


Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
            180                 185                 190         


Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
        195                 200                 205             


Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
    210                 215                 220                 


Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
225                 230                 235                 240 


Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                245                 250                 255     


Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
            260                 265                 270         


Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
        275                 280                 285             


His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
    290                 295                 300                 


Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
305                 310                 315                 320 


Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                325                 330                 335     


Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
            340                 345                 350         


Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
        355                 360                 365             


Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
    370                 375                 380                 


Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
385                 390                 395                 400 


Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
                405                 410                 415     


Tyr 
    


<210>  1105
<211>  1972
<212>  DNA
<213>  Homosapiens

<400>  1105
aaagactgcg gttcctgtta ctcagcagcc tcaaaaactc acaccagctc ctgcaaggaa     60

tgtgaatctt ggagctccca gctattctgt tcctgtttct gtcagctcct tccctgaaaa    120

ctcagaggtg ctcagcatgc catgctaaaa ggcaaaataa aaagatcttg gagacatctc    180

agctttaatg aggactttcc aacattccag actgccgtcc tgcaatgaag ctctgagtca    240

cggtctgtga ggctaaggta ctggcaacgg tgtgaacccc aggacaacta acctcactaa    300

ccttcactct aagcagaagc ccaaagtgag tctggcctga aatcagagca agcactacag    360

aaagacatct ttgttaatgg aaagaggaaa gaagaaaaga atttccaata agttacaaca    420

aacttttcac cattctaaag aacccacttt ccttatcaac caagctgggc ttctctctag    480

tgactcctat tctagccttt ccccagaaac agagagtgtt aatcctggtg aaaatataaa    540

gacagacact cagaaaaaga gacctgggac tgtgatacta tcaaaactgt caagtagaag    600

aattatatcg gaaagccagc ttagcccccc tgtgatcccg gcccgcaggc ctggattccg    660

ggtatgctat atctgtggcc gagaatttgg gtcccagtca attgccattc atgaacccca    720

gtgcttgcag aagtggcata ttgaaaacag caagttgccc aagcatttga ggaggccaga    780

accctccaaa ccacagtctc tcagcagcag tgggtcctac agtcttcagg caactaacga    840

ggctgcattt cagagtgccc aggctcagct gctgccctgt gaatcctgtg gccgcacatt    900

cttgccagat catcttcttg ttcatcacag aagctgcaag ccaaagggtg agggtcccag    960

agcaccacac tcaaacagtt ctgatcatct tactggcctc aagaaagctt gtagtggaac   1020

cccagcccga ccaaggactg ttatctgcta catatgtggt aaggaatttg gcaccctgtc   1080

ccttcctatt catgagccca aatgcctgga aaagtggaaa atggaaaatg accggctccc   1140

tgtggagctc caccagccac tcccacagaa gcctcagccc cttccgaatg cacagtccag   1200

ccaagcggga ccaaatcaag ctcagcttgt gttctgccca cattgtagcc gaatctttac   1260

ctcagaccgc ctcctggtac accagagaag ttgtaaaact catccttatg ggccaaaata   1320

tcagaatttg aatttaggga gtaaaggagg cctaaaagag tacactaatt ccaagcagca   1380

aaggaacagg gcagcaccca gtgtaactga taaggtaatt catgccacac aagacgcatt   1440

aggtgaacct ggtggtgccc tctgcctgta ggggaacaag agaaaactat ccccagaatc   1500

agccacctca gcccctagta ttttttctat caatgccttg tatcagcctc aaagcagcct   1560

gttcaagtta actccctgtt gaactccagg gcctatacct ctcttggctg aatagatata   1620

agaacatcct tgcctgatgg gttcatattc ctcttcaatt ctgctgtcta aaagaagaag   1680

agatggactt ctttcttccc tgatccctga tacaaataat ccctgggaga gacagtaatt   1740

tgaaaatgag tcattaatgc tgtgtctaca ttacagagat ataattccca ttccaacagc   1800

caatatttat tgccggttta ttttagtcat ctaccttagg aattcatttt tggcaatgct   1860

gggttatgct gagtttatct tactaaaata gaatctgtgt caaaaacccc caatgacttt   1920

agcaacaatt aaacactgaa gcacttgcaa aaatacaaaa aaaaaaaaaa aa           1972


<210>  1106
<211>  364
<212>  PRT
<213>  Homosapiens

<400>  1106

Met Glu Arg Gly Lys Lys Lys Arg Ile Ser Asn Lys Leu Gln Gln Thr 
1               5                   10                  15      


Phe His His Ser Lys Glu Pro Thr Phe Leu Ile Asn Gln Ala Gly Leu 
            20                  25                  30          


Leu Ser Ser Asp Ser Tyr Ser Ser Leu Ser Pro Glu Thr Glu Ser Val 
        35                  40                  45              


Asn Pro Gly Glu Asn Ile Lys Thr Asp Thr Gln Lys Lys Arg Pro Gly 
    50                  55                  60                  


Thr Val Ile Leu Ser Lys Leu Ser Ser Arg Arg Ile Ile Ser Glu Ser 
65                  70                  75                  80  


Gln Leu Ser Pro Pro Val Ile Pro Ala Arg Arg Pro Gly Phe Arg Val 
                85                  90                  95      


Cys Tyr Ile Cys Gly Arg Glu Phe Gly Ser Gln Ser Ile Ala Ile His 
            100                 105                 110         


Glu Pro Gln Cys Leu Gln Lys Trp His Ile Glu Asn Ser Lys Leu Pro 
        115                 120                 125             


Lys His Leu Arg Arg Pro Glu Pro Ser Lys Pro Gln Ser Leu Ser Ser 
    130                 135                 140                 


Ser Gly Ser Tyr Ser Leu Gln Ala Thr Asn Glu Ala Ala Phe Gln Ser 
145                 150                 155                 160 


Ala Gln Ala Gln Leu Leu Pro Cys Glu Ser Cys Gly Arg Thr Phe Leu 
                165                 170                 175     


Pro Asp His Leu Leu Val His His Arg Ser Cys Lys Pro Lys Gly Glu 
            180                 185                 190         


Gly Pro Arg Ala Pro His Ser Asn Ser Ser Asp His Leu Thr Gly Leu 
        195                 200                 205             


Lys Lys Ala Cys Ser Gly Thr Pro Ala Arg Pro Arg Thr Val Ile Cys 
    210                 215                 220                 


Tyr Ile Cys Gly Lys Glu Phe Gly Thr Leu Ser Leu Pro Ile His Glu 
225                 230                 235                 240 


Pro Lys Cys Leu Glu Lys Trp Lys Met Glu Asn Asp Arg Leu Pro Val 
                245                 250                 255     


Glu Leu His Gln Pro Leu Pro Gln Lys Pro Gln Pro Leu Pro Asn Ala 
            260                 265                 270         


Gln Ser Ser Gln Ala Gly Pro Asn Gln Ala Gln Leu Val Phe Cys Pro 
        275                 280                 285             


His Cys Ser Arg Ile Phe Thr Ser Asp Arg Leu Leu Val His Gln Arg 
    290                 295                 300                 


Ser Cys Lys Thr His Pro Tyr Gly Pro Lys Tyr Gln Asn Leu Asn Leu 
305                 310                 315                 320 


Gly Ser Lys Gly Gly Leu Lys Glu Tyr Thr Asn Ser Lys Gln Gln Arg 
                325                 330                 335     


Asn Arg Ala Ala Pro Ser Val Thr Asp Lys Val Ile His Ala Thr Gln 
            340                 345                 350         


Asp Ala Leu Gly Glu Pro Gly Gly Ala Leu Cys Leu 
        355                 360                 


<210>  1107
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1107
ctttccaata tccgtcttcg gagcgcacgg gaatccgccg agctctgcgt gcaggccctt     60

ttttcttttg aggttcacat tttttgaaat tttacgccag ggcttttgta atttcctccc    120

ccgcccgctg acggtcctgg agtcgctcgg ggctttaggc cggttatgca acgtgtaccg    180

ctcggggctg ccggctgcac ctccgccgcg cctcgccgct cactgcgcta gacccggcgc    240

cccgcgtctc gcttcgcggg cagtcagggg gccggcgctc tgtcgaggtc tccagctaga    300

gcagggagcc cgagcccgag ggagtccccg gagccgacga agggcttatt agaccctgac    360

tcttttctga ggcgcgcaga ttttgtcttt gatcactccc tctccgcggg tctacggccg    420

cgcgctttcg gcgccggcga tggggagaag acggaggctg tgtctccagc tctacttcct    480

gtggctgggc tgtgtggtgc tctgggcgca gggcacggcc ggccagcctc agcctcctcc    540

gcccaagccg ccccggcccc agccgccgcc gcaacaggtt cggtccgcta cagcaggctc    600

tgaaggcggg tttctagcgc ccgagtatcg cgaggagggt gccgcagtgg ccagccgcgt    660

ccgccggcga ggacagcagg acgtgctccg agggcccaac gtgtgcggct ccagattcca    720

ctcctactgc tgccctggat ggaagacgct ccctggagga aaccagtgca ttgtcccgat    780

ttgtagaaat agttgtggag atggattttg ttcccgtcct aacatgtgta cttgttccag    840

tgggcaaata tcatcaacct gtggatcaaa atcaattcag cagtgcagtg tgagatgcat    900

gaatggtggg acctgtgcag atgaccactg ccagtgccag aaaggatata ttggaactta    960

ttgtggacaa cctgtctgtg aaaatggatg tcagaatggt ggacgttgca tcggacccaa   1020

ccgctgtgct tgtgtttatg ggttcactgg tccacagtgt gaaagagatt acaggacagg   1080

cccgtgtttc actcaggtca acaaccagat gtgccaaggg cagctgacag gcattgtctg   1140

cacgaagact ctgtgctgtg ccaccattgg acgggcgtgg ggccatccct gtgagatgtg   1200

tccagcccag cctcagccct gccgacgggg tttcatcccc aacatccgca ctggagcttg   1260

ccaagatgtt gatgaatgcc aggctatccc agggatatgc caaggaggaa actgtatcaa   1320

tacagtgggc tcttttgaat gcagatgccc tgctggtcac aaacagagtg aaactactca   1380

gaaatgtgaa gacattgatg agtgcagcat cattcctggg atatgtgaaa ctggtgaatg   1440

ttccaacacc gtgggaagct atttttgtgt ttgtccacgt ggatatgtaa cctcaacaga   1500

tggctctcga tgcatcgatc agagaacagg catgtgtttc tcgggcctgg tgaatggccg   1560

ctgtgcacaa gagctcccgg ggagaatgac gaaaatgcag tgctgctgtg agcctggccg   1620

ctgctggggc atcggaacca ttcctgaagc ctgtcctgtc agaggttctg aggaatatcg   1680

cagactttgc atggatggac ttccaatggg aggaattcca gggagtgctg gttccagacc   1740

tggaggcact gggggaaatg gctttgcccc aagtggcaat ggcaatggct atggcccagg   1800

agggacaggc ttcatcccca tccctggagg caatggcttt tctcctggcg ttgggggagc   1860

cggtgtgggg gccgggggac agggacctat catcactgga ctaacaattc tgaaccagac   1920

aatagatatc tgtaagcatc atgctaacct ttgtttaaat ggacgctgta taccaactgt   1980

ctcaagctac cgatgtgaat gcaacatggg ttataagcag gatgcaaatg gagattgtat   2040

agatgttgat gaatgcacat caaatccctg cactaatgga gattgtgtta acacacctgg   2100

ttcctattat tgtaaatgtc atgctggatt ccagaggact cctaccaagc aagcatgcat   2160

tgatattgat gagtgcatcc agaatggggt tctttgtaaa aacggtcgat gcgtgaacac   2220

agatggaagt ttccagtgca tttgcaatgc cggctttgaa ttaactacag atggaaaaaa   2280

ctgtgttgat catgatgaat gtacaactac caacatgtgt ttgaatggaa tgtgcatcaa   2340

tgaagatggc agcttcaagt gcatctgcaa accaggattt gtcttggctc caaatgggcg   2400

ttactgtact gatgttgatg aatgccagac cccaggaatc tgcatgaatg ggcactgcat   2460

caacagtgaa gggtccttcc gctgtgactg tcccccaggc ctggctgtgg gcatggatgg   2520

acgtgtgtgt gttgatactc acatgcgcag tacctgctat ggaggaatca agaaaggagt   2580

gtgtgtgcgt cctttccccg gtgcagtgac caagtccgaa tgctgctgtg ccaatccaga   2640

ctatggtttt ggagaaccct gccagccatg ccctgcaaaa aattcagctg aattccacgg   2700

cctttgtagt agtggagtag gtatcactgt ggatggaaga gatatcaatg aatgtgcttt   2760

ggatcctgat atatgtgcca atgggatttg tgaaaactta cgtggtagtt accgttgtaa   2820

ttgcaacagt ggctatgaac cagatgcctc tggaagaaac tgtattgaca ttgatgaatg   2880

tttagtaaac agactgcttt gtgataacgg attgtgccga aacacgccag gaagttacag   2940

ctgtacgtgc ccaccagggt atgtgttcag gactgagaca gagacctgtg aagatataaa   3000

tgaatgtgaa agcaacccat gtgtcaatgg ggcctgcaga aacaaccttg gatctttcaa   3060

ttgtgaatgt tcgcccggca gcaaactcag ctccacagga ttgatctgta ttgacagcct   3120

gaaggggacc tgttggctca acatccagga cagccgctgt gaggtgaata ttaatggagc   3180

cactctgaaa tctgaatgct gtgccaccct cggagccgcc tgggggagcc cctgtgagcg   3240

gtgtgaacta gatacagctt gcccaagagg gcttgccagg attaaaggtg ttacgtgtga   3300

agatgttaat gagtgtgagg tgttccctgg cgtttgtcca aatggacgct gtgtcaacag   3360

taagggatct tttcattgcg agtgccctga aggccttacg ttggatggga ctggccgtgt   3420

atgtttggat attcgcatgg agcagtgtta cttgaagtgg gatgaagatg aatgcatcca   3480

ccccgttcct ggaaagttcc gcatggatgc ctgctgctgt gctgtcgggg cggcttgggg   3540

caccgagtgt gaggagtgcc ccaaacctgg caccaaggaa tacgagacgc tgtgcccccg   3600

cggggctggc tttgctaacc gaggggatgt tcttactggg cggccatttt acaaagacat   3660

caatgaatgc aaagcatttc ctgggatgtg cacttatggg aagtgcagaa atacaatcgg   3720

aagcttcaaa tgccgttgca atagtggctt tgctctagac atggaggaaa gaaactgcac   3780

ggacatcgac gagtgcagga tttctcctga cctctgtggc agtggaatct gcgtcaatac   3840

accgggcagc tttgagtgcg agtgcttcga aggctatgaa agtggcttca tgatgatgaa   3900

gaactgcatg gacattgacg aatgtgaacg taaccctctc ctttgtaggg gtggcacctg   3960

tgtgaacact gagggcagct ttcagtgtga ctgcccactg ggacacgagc tgtcaccatc   4020

ccgtgaggac tgtgtggata ttaatgaatg ctccctgagt gacaatctct gcagaaatgg   4080

aaaatgtgtg aacatgattg gaacctatca gtgctcttgc aatcctggat atcaggctac   4140

gccagaccgc cagggctgta cagatattga tgaatgtatg ataatgaacg gaggctgtga   4200

cacccagtgc acaaattcag agggaagcta cgaatgcagc tgcagtgagg gttatgccct   4260

gatgccagat gggagatcgt gtgcagacat tgatgaatgt gaaaacaatc ctgatatctg   4320

tgatggcggc cagtgtacca acattcctgg agagtatcgc tgcctctgct atgatggctt   4380

catggcttcc atggacatga aaacatgcat tgatgtcaat gaatgtgacc taaattcaaa   4440

tatctgcatg tttggggaat gtgagaacac aaagggatcc ttcatttgcc actgtcagct   4500

gggttactca gtgaagaagg ggaccacagg atgtacagat gtggatgagt gtgaaattgg   4560

tgctcataac tgcgacatgc atgcctcatg tctgaatatc ccaggaagct tcaagtgtag   4620

ctgcagagaa ggctggattg gaaacggcat caagtgtatt gatctggacg aatgttctaa   4680

tggaacccac cagtgtagca tcaatgctca gtgtgtaaat accccgggct cataccgctg   4740

tgcctgctcc gaaggtttca ctggtgatgg ctttacctgc tcagatgttg atgagtgtgc   4800

agaaaacata aacctctgtg agaacggaca gtgccttaat gtcccgggtg catatcgctg   4860

cgagtgtgag atgggcttca ctccagcctc agacagcaga tcctgccaag atattgatga   4920

atgctccttc caaaacattt gtgtctttgg aacatgtaat aacctgcctg gaatgtttca   4980

ttgcatctgc gatgatggtt atgaattgga cagaacagga gggaactgta cagatattga   5040

tgagtgtgca gatcctataa actgtgtcaa tggcctatgt gtcaacacgc ctggtcgcta   5100

tgagtgtaac tgcccacccg attttcagtt gaacccaact ggtgtgggtt gtgttgacaa   5160

ccgtgtgggc aactgctacc tgaagtttgg acctcgagga gatgggagtc tgtcttgcaa   5220

caccgagatc ggggtgggcg tcagtcgctc ttcatgctgc tgctctctgg gaaaggcctg   5280

gggaaacccc tgtgagacat gcccccctgt caatagcact gaatattaca ccctgtgtcc   5340

cggaggtgaa ggcttcagac ctaaccccat cacaatcatt ttagaagaca ttgacgaatg   5400

ccaggagtta ccaggtctct gccagggtgg aaactgcatc aacacttttg ggagcttcca   5460

gtgtgagtgc ccacaaggct actacctcag cgaggatacc cgcatctgtg aagatattga   5520

tgagtgtttt gcacatcctg gtgtgtgtgg gcctgggacc tgctataaca ccctgggaaa   5580

ttacacctgc atttgcccac ctgagtacat gcaggtcaat ggaggccaca actgcatgga   5640

catgagaaaa agcttttgct accgaagcta taatggaacc acttgtgaga atgagttgcc   5700

tttcaatgtg acaaaaagga tgtgctgctg cacatataat gtgggcaaag cctggaacaa   5760

accttgtgaa ccatgcccaa ctccaggaac agctgacttt aaaaccatat gtggaaatat   5820

tcctggattc acctttgaca ttcacacagg aaaagctgtt gacattgatg aatgtaaaga   5880

gattccaggc atttgtgcaa atggtgtgtg cattaaccag attggcagtt tccgctgtga   5940

atgccctaca ggattcagtt acaatgacct gctgttggtt tgtgaagata tagatgagtg   6000

cagcaatggt gataatctct gccagcggaa tgcagactgc atcaatagtc ctggtagtta   6060

ccgctgtgaa tgtgccgcgg gtttcaaact ttcacccaat ggggcctgtg tagatcgcaa   6120

tgaatgttta gaaattccta acgtttgcag tcatggcttg tgtgttgatc tgcaaggaag   6180

ttaccagtgc atctgccaca atggctttaa ggcttctcag gaccagacca tgtgcatgga   6240

tgttgatgag tgcgagcggc atccatgtgg aaatggaact tgtaaaaaca ccgttggatc   6300

ctataactgt ctgtgctacc cagggtttga actcactcat aataatgatt gcctggacat   6360

agatgagtgc agttcctttt ttggtcaggt gtgcagaaat ggacgttgtt ttaatgaaat   6420

tggttctttc aagtgtctat gtaacgaagg ttatgaactt accccagatg gcaaaaactg   6480

tatagacact aatgagtgtg tcgcccttcc cggctcttgc tctcctggta cctgtcagaa   6540

tttggaggga tccttcagat gcatctgtcc cccagggtat gaagtaaaaa gcgagaactg   6600

cattgatata aatgaatgtg atgaagatcc caacatttgt ctttttggtt cctgtactaa   6660

tactccaggg ggcttccagt gcctctgccc ccctggcttt gtactatctg ataatggacg   6720

gagatgcttt gatactcgcc agagcttctg cttcacaaat tttgaaaatg gaaagtgttc   6780

tgtacccaaa gctttcaaca ccacaaaagc aaaatgctgc tgtagtaaga tgccaggaga   6840

gggctggggg gacccctgtg agctgtgccc caaagacgat gaagttgcat ttcaggattt   6900

gtgtccatat ggccatggaa ctgtccctag tcttcatgat acacgtgaag atgtcaatga   6960

gtgtcttgag agcccaggca tttgttcaaa tggtcaatgt atcaacaccg acggatcttt   7020

tcgctgtgaa tgtccaatgg gctacaacct tgactacact ggagtacgct gtgtggatac   7080

tgatgagtgt tcaatcggca atccgtgtgg aaatggtaca tgcaccaatg ttattgggag   7140

ttttgaatgc aattgcaatg aaggctttga gccagggccc atgatgaatt gtgaagatat   7200

caacgaatgt gcccagaacc cactgctgtg tgctttccgc tgcatgaaca cttttgggtc   7260

ctatgaatgc acgtgcccga ttggctatgc cctcagggaa gatcaaaaga tgtgcaaaga   7320

tctggatgaa tgtgctgaag ggttacacga ctgtgaatct aggggcatga tgtgtaagaa   7380

tctaatcggc accttcatgt gcatctgccc tcctggaatg gcccgaaggc ccgatggaga   7440

aggctgtgta gatgaaaatg aatgcaggac caagccagga atctgtgaaa atggacgttg   7500

tgttaacatt attggaagct atagatgtga gtgtaatgaa ggattccagt caagttcttc   7560

aggcactgaa tgccttgaca atcgacaggg tctctgcttt gcagaggtac tgcagacaat   7620

atgtcaaatg gcatccagta gtcgcaatct cgtcactaag tcagaatgct gctgtgatgg   7680

tgggcgaggc tggggccacc agtgcgagct ttgcccactt cctggaactg cccagtacaa   7740

aaagatatgt cctcatggcc caggatatac aactgatgga agagatattg atgaatgtaa   7800

ggtaatgcca aacctctgca ccaatggtca gtgcatcaat accatgggct cattccgatg   7860

cttctgcaag gttggctaca ccacagacat cagtggaacc tcttgtatag accttgatga   7920

atgctcccag tccccgaaac catgcaacta catctgcaag aacactgagg ggagttatca   7980

gtgttcatgt ccgagggggt atgtcctgca agaggatgga aagacatgca aagaccttga   8040

tgaatgtcaa acaaagcagc ataactgcca gttcctctgt gtcaacaccc tgggggggtt   8100

tacctgtaaa tgtccacctg gtttcacaca gcatcacact gcttgtatcg acaacaacga   8160

atgtgggtct caaccttcgc tttgtggagc aa                                 8192


<210>  1108
<211>  2912
<212>  PRT
<213>  Homosapiens

<400>  1108

Met Gly Arg Arg Arg Arg Leu Cys Leu Gln Leu Tyr Phe Leu Trp Leu 
1               5                   10                  15      


Gly Cys Val Val Leu Trp Ala Gln Gly Thr Ala Gly Gln Pro Gln Pro 
            20                  25                  30          


Pro Pro Pro Lys Pro Pro Arg Pro Gln Pro Pro Pro Gln Gln Val Arg 
        35                  40                  45              


Ser Ala Thr Ala Gly Ser Glu Gly Gly Phe Leu Ala Pro Glu Tyr Arg 
    50                  55                  60                  


Glu Glu Gly Ala Ala Val Ala Ser Arg Val Arg Arg Arg Gly Gln Gln 
65                  70                  75                  80  


Asp Val Leu Arg Gly Pro Asn Val Cys Gly Ser Arg Phe His Ser Tyr 
                85                  90                  95      


Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys Ile Val 
            100                 105                 110         


Pro Ile Cys Arg Asn Ser Cys Gly Asp Gly Phe Cys Ser Arg Pro Asn 
        115                 120                 125             


Met Cys Thr Cys Ser Ser Gly Gln Ile Ser Ser Thr Cys Gly Ser Lys 
    130                 135                 140                 


Ser Ile Gln Gln Cys Ser Val Arg Cys Met Asn Gly Gly Thr Cys Ala 
145                 150                 155                 160 


Asp Asp His Cys Gln Cys Gln Lys Gly Tyr Ile Gly Thr Tyr Cys Gly 
                165                 170                 175     


Gln Pro Val Cys Glu Asn Gly Cys Gln Asn Gly Gly Arg Cys Ile Gly 
            180                 185                 190         


Pro Asn Arg Cys Ala Cys Val Tyr Gly Phe Thr Gly Pro Gln Cys Glu 
        195                 200                 205             


Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Gln Val Asn Asn Gln Met 
    210                 215                 220                 


Cys Gln Gly Gln Leu Thr Gly Ile Val Cys Thr Lys Thr Leu Cys Cys 
225                 230                 235                 240 


Ala Thr Ile Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys Pro Ala 
                245                 250                 255     


Gln Pro Gln Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg Thr Gly 
            260                 265                 270         


Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Ile Cys Gln 
        275                 280                 285             


Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Arg Cys Pro 
    290                 295                 300                 


Ala Gly His Lys Gln Ser Glu Thr Thr Gln Lys Cys Glu Asp Ile Asp 
305                 310                 315                 320 


Glu Cys Ser Ile Ile Pro Gly Ile Cys Glu Thr Gly Glu Cys Ser Asn 
                325                 330                 335     


Thr Val Gly Ser Tyr Phe Cys Val Cys Pro Arg Gly Tyr Val Thr Ser 
            340                 345                 350         


Thr Asp Gly Ser Arg Cys Ile Asp Gln Arg Thr Gly Met Cys Phe Ser 
        355                 360                 365             


Gly Leu Val Asn Gly Arg Cys Ala Gln Glu Leu Pro Gly Arg Met Thr 
    370                 375                 380                 


Lys Met Gln Cys Cys Cys Glu Pro Gly Arg Cys Trp Gly Ile Gly Thr 
385                 390                 395                 400 


Ile Pro Glu Ala Cys Pro Val Arg Gly Ser Glu Glu Tyr Arg Arg Leu 
                405                 410                 415     


Cys Met Asp Gly Leu Pro Met Gly Gly Ile Pro Gly Ser Ala Gly Ser 
            420                 425                 430         


Arg Pro Gly Gly Thr Gly Gly Asn Gly Phe Ala Pro Ser Gly Asn Gly 
        435                 440                 445             


Asn Gly Tyr Gly Pro Gly Gly Thr Gly Phe Ile Pro Ile Pro Gly Gly 
    450                 455                 460                 


Asn Gly Phe Ser Pro Gly Val Gly Gly Ala Gly Val Gly Ala Gly Gly 
465                 470                 475                 480 


Gln Gly Pro Ile Ile Thr Gly Leu Thr Ile Leu Asn Gln Thr Ile Asp 
                485                 490                 495     


Ile Cys Lys His His Ala Asn Leu Cys Leu Asn Gly Arg Cys Ile Pro 
            500                 505                 510         


Thr Val Ser Ser Tyr Arg Cys Glu Cys Asn Met Gly Tyr Lys Gln Asp 
        515                 520                 525             


Ala Asn Gly Asp Cys Ile Asp Val Asp Glu Cys Thr Ser Asn Pro Cys 
    530                 535                 540                 


Thr Asn Gly Asp Cys Val Asn Thr Pro Gly Ser Tyr Tyr Cys Lys Cys 
545                 550                 555                 560 


His Ala Gly Phe Gln Arg Thr Pro Thr Lys Gln Ala Cys Ile Asp Ile 
                565                 570                 575     


Asp Glu Cys Ile Gln Asn Gly Val Leu Cys Lys Asn Gly Arg Cys Val 
            580                 585                 590         


Asn Thr Asp Gly Ser Phe Gln Cys Ile Cys Asn Ala Gly Phe Glu Leu 
        595                 600                 605             


Thr Thr Asp Gly Lys Asn Cys Val Asp His Asp Glu Cys Thr Thr Thr 
    610                 615                 620                 


Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly Ser Phe Lys 
625                 630                 635                 640 


Cys Ile Cys Lys Pro Gly Phe Val Leu Ala Pro Asn Gly Arg Tyr Cys 
                645                 650                 655     


Thr Asp Val Asp Glu Cys Gln Thr Pro Gly Ile Cys Met Asn Gly His 
            660                 665                 670         


Cys Ile Asn Ser Glu Gly Ser Phe Arg Cys Asp Cys Pro Pro Gly Leu 
        675                 680                 685             


Ala Val Gly Met Asp Gly Arg Val Cys Val Asp Thr His Met Arg Ser 
    690                 695                 700                 


Thr Cys Tyr Gly Gly Ile Lys Lys Gly Val Cys Val Arg Pro Phe Pro 
705                 710                 715                 720 


Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Asn Pro Asp Tyr Gly 
                725                 730                 735     


Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Lys Asn Ser Ala Glu Phe 
            740                 745                 750         


His Gly Leu Cys Ser Ser Gly Val Gly Ile Thr Val Asp Gly Arg Asp 
        755                 760                 765             


Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Ala Asn Gly Ile Cys 
    770                 775                 780                 


Glu Asn Leu Arg Gly Ser Tyr Arg Cys Asn Cys Asn Ser Gly Tyr Glu 
785                 790                 795                 800 


Pro Asp Ala Ser Gly Arg Asn Cys Ile Asp Ile Asp Glu Cys Leu Val 
                805                 810                 815     


Asn Arg Leu Leu Cys Asp Asn Gly Leu Cys Arg Asn Thr Pro Gly Ser 
            820                 825                 830         


Tyr Ser Cys Thr Cys Pro Pro Gly Tyr Val Phe Arg Thr Glu Thr Glu 
        835                 840                 845             


Thr Cys Glu Asp Ile Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly 
    850                 855                 860                 


Ala Cys Arg Asn Asn Leu Gly Ser Phe Asn Cys Glu Cys Ser Pro Gly 
865                 870                 875                 880 


Ser Lys Leu Ser Ser Thr Gly Leu Ile Cys Ile Asp Ser Leu Lys Gly 
                885                 890                 895     


Thr Cys Trp Leu Asn Ile Gln Asp Ser Arg Cys Glu Val Asn Ile Asn 
            900                 905                 910         


Gly Ala Thr Leu Lys Ser Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp 
        915                 920                 925             


Gly Ser Pro Cys Glu Arg Cys Glu Leu Asp Thr Ala Cys Pro Arg Gly 
    930                 935                 940                 


Leu Ala Arg Ile Lys Gly Val Thr Cys Glu Asp Val Asn Glu Cys Glu 
945                 950                 955                 960 


Val Phe Pro Gly Val Cys Pro Asn Gly Arg Cys Val Asn Ser Lys Gly 
                965                 970                 975     


Ser Phe His Cys Glu Cys Pro Glu Gly Leu Thr Leu Asp Gly Thr Gly 
            980                 985                 990         


Arg Val Cys Leu Asp Ile Arg Met  Glu Gln Cys Tyr Leu  Lys Trp Asp 
        995                 1000                 1005             


Glu Asp  Glu Cys Ile His Pro  Val Pro Gly Lys Phe  Arg Met Asp 
    1010                 1015                 1020             


Ala Cys  Cys Cys Ala Val Gly  Ala Ala Trp Gly Thr  Glu Cys Glu 
    1025                 1030                 1035             


Glu Cys  Pro Lys Pro Gly Thr  Lys Glu Tyr Glu Thr  Leu Cys Pro 
    1040                 1045                 1050             


Arg Gly  Ala Gly Phe Ala Asn  Arg Gly Asp Val Leu  Thr Gly Arg 
    1055                 1060                 1065             


Pro Phe  Tyr Lys Asp Ile Asn  Glu Cys Lys Ala Phe  Pro Gly Met 
    1070                 1075                 1080             


Cys Thr  Tyr Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1085                 1090                 1095             


Arg Cys  Asn Ser Gly Phe Ala  Leu Asp Met Glu Glu  Arg Asn Cys 
    1100                 1105                 1110             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Ser 
    1115                 1120                 1125             


Gly Ile  Cys Val Asn Thr Pro  Gly Ser Phe Glu Cys  Glu Cys Phe 
    1130                 1135                 1140             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1145                 1150                 1155             


Ile Asp  Glu Cys Glu Arg Asn  Pro Leu Leu Cys Arg  Gly Gly Thr 
    1160                 1165                 1170             


Cys Val  Asn Thr Glu Gly Ser  Phe Gln Cys Asp Cys  Pro Leu Gly 
    1175                 1180                 1185             


His Glu  Leu Ser Pro Ser Arg  Glu Asp Cys Val Asp  Ile Asn Glu 
    1190                 1195                 1200             


Cys Ser  Leu Ser Asp Asn Leu  Cys Arg Asn Gly Lys  Cys Val Asn 
    1205                 1210                 1215             


Met Ile  Gly Thr Tyr Gln Cys  Ser Cys Asn Pro Gly  Tyr Gln Ala 
    1220                 1225                 1230             


Thr Pro  Asp Arg Gln Gly Cys  Thr Asp Ile Asp Glu  Cys Met Ile 
    1235                 1240                 1245             


Met Asn  Gly Gly Cys Asp Thr  Gln Cys Thr Asn Ser  Glu Gly Ser 
    1250                 1255                 1260             


Tyr Glu  Cys Ser Cys Ser Glu  Gly Tyr Ala Leu Met  Pro Asp Gly 
    1265                 1270                 1275             


Arg Ser  Cys Ala Asp Ile Asp  Glu Cys Glu Asn Asn  Pro Asp Ile 
    1280                 1285                 1290             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1295                 1300                 1305             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Met Asp Met  Lys Thr Cys 
    1310                 1315                 1320             


Ile Asp  Val Asn Glu Cys Asp  Leu Asn Ser Asn Ile  Cys Met Phe 
    1325                 1330                 1335             


Gly Glu  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Gln 
    1340                 1345                 1350             


Leu Gly  Tyr Ser Val Lys Lys  Gly Thr Thr Gly Cys  Thr Asp Val 
    1355                 1360                 1365             


Asp Glu  Cys Glu Ile Gly Ala  His Asn Cys Asp Met  His Ala Ser 
    1370                 1375                 1380             


Cys Leu  Asn Ile Pro Gly Ser  Phe Lys Cys Ser Cys  Arg Glu Gly 
    1385                 1390                 1395             


Trp Ile  Gly Asn Gly Ile Lys  Cys Ile Asp Leu Asp  Glu Cys Ser 
    1400                 1405                 1410             


Asn Gly  Thr His Gln Cys Ser  Ile Asn Ala Gln Cys  Val Asn Thr 
    1415                 1420                 1425             


Pro Gly  Ser Tyr Arg Cys Ala  Cys Ser Glu Gly Phe  Thr Gly Asp 
    1430                 1435                 1440             


Gly Phe  Thr Cys Ser Asp Val  Asp Glu Cys Ala Glu  Asn Ile Asn 
    1445                 1450                 1455             


Leu Cys  Glu Asn Gly Gln Cys  Leu Asn Val Pro Gly  Ala Tyr Arg 
    1460                 1465                 1470             


Cys Glu  Cys Glu Met Gly Phe  Thr Pro Ala Ser Asp  Ser Arg Ser 
    1475                 1480                 1485             


Cys Gln  Asp Ile Asp Glu Cys  Ser Phe Gln Asn Ile  Cys Val Phe 
    1490                 1495                 1500             


Gly Thr  Cys Asn Asn Leu Pro  Gly Met Phe His Cys  Ile Cys Asp 
    1505                 1510                 1515             


Asp Gly  Tyr Glu Leu Asp Arg  Thr Gly Gly Asn Cys  Thr Asp Ile 
    1520                 1525                 1530             


Asp Glu  Cys Ala Asp Pro Ile  Asn Cys Val Asn Gly  Leu Cys Val 
    1535                 1540                 1545             


Asn Thr  Pro Gly Arg Tyr Glu  Cys Asn Cys Pro Pro  Asp Phe Gln 
    1550                 1555                 1560             


Leu Asn  Pro Thr Gly Val Gly  Cys Val Asp Asn Arg  Val Gly Asn 
    1565                 1570                 1575             


Cys Tyr  Leu Lys Phe Gly Pro  Arg Gly Asp Gly Ser  Leu Ser Cys 
    1580                 1585                 1590             


Asn Thr  Glu Ile Gly Val Gly  Val Ser Arg Ser Ser  Cys Cys Cys 
    1595                 1600                 1605             


Ser Leu  Gly Lys Ala Trp Gly  Asn Pro Cys Glu Thr  Cys Pro Pro 
    1610                 1615                 1620             


Val Asn  Ser Thr Glu Tyr Tyr  Thr Leu Cys Pro Gly  Gly Glu Gly 
    1625                 1630                 1635             


Phe Arg  Pro Asn Pro Ile Thr  Ile Ile Leu Glu Asp  Ile Asp Glu 
    1640                 1645                 1650             


Cys Gln  Glu Leu Pro Gly Leu  Cys Gln Gly Gly Asn  Cys Ile Asn 
    1655                 1660                 1665             


Thr Phe  Gly Ser Phe Gln Cys  Glu Cys Pro Gln Gly  Tyr Tyr Leu 
    1670                 1675                 1680             


Ser Glu  Asp Thr Arg Ile Cys  Glu Asp Ile Asp Glu  Cys Phe Ala 
    1685                 1690                 1695             


His Pro  Gly Val Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Leu Gly 
    1700                 1705                 1710             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Glu Tyr Met Gln  Val Asn Gly 
    1715                 1720                 1725             


Gly His  Asn Cys Met Asp Met  Arg Lys Ser Phe Cys  Tyr Arg Ser 
    1730                 1735                 1740             


Tyr Asn  Gly Thr Thr Cys Glu  Asn Glu Leu Pro Phe  Asn Val Thr 
    1745                 1750                 1755             


Lys Arg  Met Cys Cys Cys Thr  Tyr Asn Val Gly Lys  Ala Trp Asn 
    1760                 1765                 1770             


Lys Pro  Cys Glu Pro Cys Pro  Thr Pro Gly Thr Ala  Asp Phe Lys 
    1775                 1780                 1785             


Thr Ile  Cys Gly Asn Ile Pro  Gly Phe Thr Phe Asp  Ile His Thr 
    1790                 1795                 1800             


Gly Lys  Ala Val Asp Ile Asp  Glu Cys Lys Glu Ile  Pro Gly Ile 
    1805                 1810                 1815             


Cys Ala  Asn Gly Val Cys Ile  Asn Gln Ile Gly Ser  Phe Arg Cys 
    1820                 1825                 1830             


Glu Cys  Pro Thr Gly Phe Ser  Tyr Asn Asp Leu Leu  Leu Val Cys 
    1835                 1840                 1845             


Glu Asp  Ile Asp Glu Cys Ser  Asn Gly Asp Asn Leu  Cys Gln Arg 
    1850                 1855                 1860             


Asn Ala  Asp Cys Ile Asn Ser  Pro Gly Ser Tyr Arg  Cys Glu Cys 
    1865                 1870                 1875             


Ala Ala  Gly Phe Lys Leu Ser  Pro Asn Gly Ala Cys  Val Asp Arg 
    1880                 1885                 1890             


Asn Glu  Cys Leu Glu Ile Pro  Asn Val Cys Ser His  Gly Leu Cys 
    1895                 1900                 1905             


Val Asp  Leu Gln Gly Ser Tyr  Gln Cys Ile Cys His  Asn Gly Phe 
    1910                 1915                 1920             


Lys Ala  Ser Gln Asp Gln Thr  Met Cys Met Asp Val  Asp Glu Cys 
    1925                 1930                 1935             


Glu Arg  His Pro Cys Gly Asn  Gly Thr Cys Lys Asn  Thr Val Gly 
    1940                 1945                 1950             


Ser Tyr  Asn Cys Leu Cys Tyr  Pro Gly Phe Glu Leu  Thr His Asn 
    1955                 1960                 1965             


Asn Asp  Cys Leu Asp Ile Asp  Glu Cys Ser Ser Phe  Phe Gly Gln 
    1970                 1975                 1980             


Val Cys  Arg Asn Gly Arg Cys  Phe Asn Glu Ile Gly  Ser Phe Lys 
    1985                 1990                 1995             


Cys Leu  Cys Asn Glu Gly Tyr  Glu Leu Thr Pro Asp  Gly Lys Asn 
    2000                 2005                 2010             


Cys Ile  Asp Thr Asn Glu Cys  Val Ala Leu Pro Gly  Ser Cys Ser 
    2015                 2020                 2025             


Pro Gly  Thr Cys Gln Asn Leu  Glu Gly Ser Phe Arg  Cys Ile Cys 
    2030                 2035                 2040             


Pro Pro  Gly Tyr Glu Val Lys  Ser Glu Asn Cys Ile  Asp Ile Asn 
    2045                 2050                 2055             


Glu Cys  Asp Glu Asp Pro Asn  Ile Cys Leu Phe Gly  Ser Cys Thr 
    2060                 2065                 2070             


Asn Thr  Pro Gly Gly Phe Gln  Cys Leu Cys Pro Pro  Gly Phe Val 
    2075                 2080                 2085             


Leu Ser  Asp Asn Gly Arg Arg  Cys Phe Asp Thr Arg  Gln Ser Phe 
    2090                 2095                 2100             


Cys Phe  Thr Asn Phe Glu Asn  Gly Lys Cys Ser Val  Pro Lys Ala 
    2105                 2110                 2115             


Phe Asn  Thr Thr Lys Ala Lys  Cys Cys Cys Ser Lys  Met Pro Gly 
    2120                 2125                 2130             


Glu Gly  Trp Gly Asp Pro Cys  Glu Leu Cys Pro Lys  Asp Asp Glu 
    2135                 2140                 2145             


Val Ala  Phe Gln Asp Leu Cys  Pro Tyr Gly His Gly  Thr Val Pro 
    2150                 2155                 2160             


Ser Leu  His Asp Thr Arg Glu  Asp Val Asn Glu Cys  Leu Glu Ser 
    2165                 2170                 2175             


Pro Gly  Ile Cys Ser Asn Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2180                 2185                 2190             


Phe Arg  Cys Glu Cys Pro Met  Gly Tyr Asn Leu Asp  Tyr Thr Gly 
    2195                 2200                 2205             


Val Arg  Cys Val Asp Thr Asp  Glu Cys Ser Ile Gly  Asn Pro Cys 
    2210                 2215                 2220             


Gly Asn  Gly Thr Cys Thr Asn  Val Ile Gly Ser Phe  Glu Cys Asn 
    2225                 2230                 2235             


Cys Asn  Glu Gly Phe Glu Pro  Gly Pro Met Met Asn  Cys Glu Asp 
    2240                 2245                 2250             


Ile Asn  Glu Cys Ala Gln Asn  Pro Leu Leu Cys Ala  Phe Arg Cys 
    2255                 2260                 2265             


Met Asn  Thr Phe Gly Ser Tyr  Glu Cys Thr Cys Pro  Ile Gly Tyr 
    2270                 2275                 2280             


Ala Leu  Arg Glu Asp Gln Lys  Met Cys Lys Asp Leu  Asp Glu Cys 
    2285                 2290                 2295             


Ala Glu  Gly Leu His Asp Cys  Glu Ser Arg Gly Met  Met Cys Lys 
    2300                 2305                 2310             


Asn Leu  Ile Gly Thr Phe Met  Cys Ile Cys Pro Pro  Gly Met Ala 
    2315                 2320                 2325             


Arg Arg  Pro Asp Gly Glu Gly  Cys Val Asp Glu Asn  Glu Cys Arg 
    2330                 2335                 2340             


Thr Lys  Pro Gly Ile Cys Glu  Asn Gly Arg Cys Val  Asn Ile Ile 
    2345                 2350                 2355             


Gly Ser  Tyr Arg Cys Glu Cys  Asn Glu Gly Phe Gln  Ser Ser Ser 
    2360                 2365                 2370             


Ser Gly  Thr Glu Cys Leu Asp  Asn Arg Gln Gly Leu  Cys Phe Ala 
    2375                 2380                 2385             


Glu Val  Leu Gln Thr Ile Cys  Gln Met Ala Ser Ser  Ser Arg Asn 
    2390                 2395                 2400             


Leu Val  Thr Lys Ser Glu Cys  Cys Cys Asp Gly Gly  Arg Gly Trp 
    2405                 2410                 2415             


Gly His  Gln Cys Glu Leu Cys  Pro Leu Pro Gly Thr  Ala Gln Tyr 
    2420                 2425                 2430             


Lys Lys  Ile Cys Pro His Gly  Pro Gly Tyr Thr Thr  Asp Gly Arg 
    2435                 2440                 2445             


Asp Ile  Asp Glu Cys Lys Val  Met Pro Asn Leu Cys  Thr Asn Gly 
    2450                 2455                 2460             


Gln Cys  Ile Asn Thr Met Gly  Ser Phe Arg Cys Phe  Cys Lys Val 
    2465                 2470                 2475             


Gly Tyr  Thr Thr Asp Ile Ser  Gly Thr Ser Cys Ile  Asp Leu Asp 
    2480                 2485                 2490             


Glu Cys  Ser Gln Ser Pro Lys  Pro Cys Asn Tyr Ile  Cys Lys Asn 
    2495                 2500                 2505             


Thr Glu  Gly Ser Tyr Gln Cys  Ser Cys Pro Arg Gly  Tyr Val Leu 
    2510                 2515                 2520             


Gln Glu  Asp Gly Lys Thr Cys  Lys Asp Leu Asp Glu  Cys Gln Thr 
    2525                 2530                 2535             


Lys Gln  His Asn Cys Gln Phe  Leu Cys Val Asn Thr  Leu Gly Gly 
    2540                 2545                 2550             


Phe Thr  Cys Lys Cys Pro Pro  Gly Phe Thr Gln His  His Thr Ala 
    2555                 2560                 2565             


Cys Ile  Asp Asn Asn Glu Cys  Gly Ser Gln Pro Ser  Leu Cys Gly 
    2570                 2575                 2580             


Ala Lys  Gly Ile Cys Gln Asn  Thr Pro Gly Ser Phe  Ser Cys Glu 
    2585                 2590                 2595             


Cys Gln  Arg Gly Phe Ser Leu  Asp Ala Thr Gly Leu  Asn Cys Glu 
    2600                 2605                 2610             


Asp Val  Asp Glu Cys Asp Gly  Asn His Arg Cys Gln  His Gly Cys 
    2615                 2620                 2625             


Gln Asn  Ile Leu Gly Gly Tyr  Arg Cys Gly Cys Pro  Gln Gly Tyr 
    2630                 2635                 2640             


Ile Gln  His Tyr Gln Trp Asn  Gln Cys Val Asp Glu  Asn Glu Cys 
    2645                 2650                 2655             


Ser Asn  Pro Asn Ala Cys Gly  Ser Ala Ser Cys Tyr  Asn Thr Leu 
    2660                 2665                 2670             


Gly Ser  Tyr Lys Cys Ala Cys  Pro Ser Gly Phe Ser  Phe Asp Gln 
    2675                 2680                 2685             


Phe Ser  Ser Ala Cys His Asp  Val Asn Glu Cys Ser  Ser Ser Lys 
    2690                 2695                 2700             


Asn Pro  Cys Asn Tyr Gly Cys  Ser Asn Thr Glu Gly  Gly Tyr Leu 
    2705                 2710                 2715             


Cys Gly  Cys Pro Pro Gly Tyr  Tyr Arg Val Gly Gln  Gly His Cys 
    2720                 2725                 2730             


Val Ser  Gly Met Gly Phe Asn  Lys Gly Gln Tyr Leu  Ser Leu Asp 
    2735                 2740                 2745             


Thr Glu  Val Asp Glu Glu Asn  Ala Leu Ser Pro Glu  Ala Cys Tyr 
    2750                 2755                 2760             


Glu Cys  Lys Ile Asn Gly Tyr  Ser Lys Lys Asp Ser  Arg Gln Lys 
    2765                 2770                 2775             


Arg Ser  Ile His Glu Pro Asp  Pro Thr Ala Val Glu  Gln Ile Ser 
    2780                 2785                 2790             


Leu Glu  Ser Val Asp Met Asp  Ser Pro Val Asn Met  Lys Phe Asn 
    2795                 2800                 2805             


Leu Ser  His Leu Gly Ser Lys  Glu His Ile Leu Glu  Leu Arg Pro 
    2810                 2815                 2820             


Ala Ile  Gln Pro Leu Asn Asn  His Ile Arg Tyr Val  Ile Ser Gln 
    2825                 2830                 2835             


Gly Asn  Asp Asp Ser Val Phe  Arg Ile His Gln Arg  Asn Gly Leu 
    2840                 2845                 2850             


Ser Tyr  Leu His Thr Ala Lys  Lys Lys Leu Met Pro  Gly Thr Tyr 
    2855                 2860                 2865             


Thr Leu  Glu Ile Thr Ser Ile  Pro Leu Tyr Lys Lys  Lys Glu Leu 
    2870                 2875                 2880             


Lys Lys  Leu Glu Glu Ser Asn  Glu Asp Asp Tyr Leu  Leu Gly Glu 
    2885                 2890                 2895             


Leu Gly  Glu Ala Leu Arg Met  Arg Leu Gln Ile Gln  Leu Tyr 
    2900                 2905                 2910         


<210>  1109
<211>  3523
<212>  DNA
<213>  Homosapiens

<400>  1109
atggctgtgc gctctcgccg cccgtggatg agcgtggcat tagggctggt gctgggcttc     60

accgccgcgt cctggctcat cgcccccagg gtggcggagc tgagcgagag gaagagacgt    120

ggctccagcc tctgctccta ctacggtcgc tctgctgctg gcccccgcgc cggcgctcag    180

cagccgctcc cccagcccca gtcccgacca cggcaggagc agtcgccgcc ccccgcgcgc    240

caggatctcc aggggccacc gctgcccgag gcagcacccg ggatcaccag ttttcgaagc    300

agcccctggc agcagccacc tccgctgcag cagcggcggc gaggacgcga gcctgagggc    360

gcgacggggc ttcccggtgc tccagcggcc gagggggagc ccgaggagga ggacgggggc    420

gcggctgggc agcggagaga cggccggccg gggagtagcc acaacggcag cggggacggg    480

ggcgctgccg ccccgagcgc ccgaccccgg gacttcctgt acgtgggggt gatgaccgcg    540

cagaagtacc tgggcagccg cgcgctggcc gcgcagcgga cctgggcgcg tttcatcccg    600

ggccgcgtgg agttcttttc cagccagcag ccccccaacg ccggccagcc cccgccaccc    660

ctgcctgtca tcgcgctacc gggtgtggac gactcctatc ctccccagaa aaagtccttc    720

atgatgatca agtacatgca cgaccactac ctggacaagt atgagtggtt catgcgcgcc    780

gacgacgatg tctacatcaa aggtgataaa ttagaagagt ttcttagatc gctaaacagc    840

agtaagcctc tctacctggg acagactggc ctggggaata ttgaagagct tggaaagctg    900

ggactggagc ctggggaaaa cttctgtatg ggaggacctg gcatgatctt tagccgagaa    960

gttctcagga ggatggtgcc acatattggt gaatgcctta gagaaatgta cacgactcat   1020

gaggatgtgg aagtaggaag atgcgttcgc cgttttggtg ggactcagtg tgtctggtct   1080

tacgagatgc aacaactgtt ccatgaaaat tatgaacaca atcggaaggg ttacatccaa   1140

gaccttcaca atagcaaaat ccatgcagcc ataacacttc atcccaacaa aaggcctgca   1200

taccaataca ggctgcataa ttacatgctc agccgcaaaa tttctgaact tcgctaccgc   1260

accatccagc tccacaggga aagtgccctg atgagcaagc tcagtaacac agaagtgagc   1320

aaagaggacc agcagctggg agtgatacct tctttcaacc acttccagcc tcgggagaga   1380

aatgaagtga tagaatggga gttcctgaca gggaagcttc tatactcagc agctgagaac   1440

cagccccctc gacagagcct cagtagcatt ttaagaacag cactggatga taccgtccta   1500

caggtgatgg agatgatcaa tgagaatgcc aagagcagag gacggctcat tgacttcaag   1560

gaaattcagt atggctaccg cagagttaac cccatgcacg gggtggagta cattttggat   1620

ttactccttt tatacaaaag acacaaggga aggaaactga ctgtgccagt gagacgtcat   1680

gcctatcttc agcagttgtt cagcaagcct ttcttcagag agaccgaaga gctagatgtc   1740

aacagtcttg tggagagtat taacagtgaa actcagtcat tctcctttat atctaattct   1800

ttaaagatat tatcttcttt tcaaggtgcc aaagaaatgg gagggcacaa tgaaaagaaa   1860

gtacacattc tcgttcctct catcggaagg tatgacattt tcttgagatt catggagaac   1920

tttgaaaaca tgtgtcttat cccaaagcag aatgtaaagt tggtcattat ccttttcagt   1980

agggattctg gccaagactc cagcaagcat attgagctga taaaagggta ccagaacaag   2040

taccccaaag cagaaatgac cctgatccca atgaagggag agttttccag aggtcttggt   2100

cttgaaatgg cttctgccca gtttgacaat gacactttgc tgctattttg tgatgttgac   2160

ttgatcttca gagaagattt tctccaacga tgtagagaca atacaattca gggacaacag   2220

gtgtactatc ccatcatctt tagccagtat gacccaaagg taacaaacgg gggaaatcct   2280

cccactgatg attacttcat attctcaaaa aagactggat tttggagaga ctatggatat   2340

ggcatcacct gtatttacaa aagtgatctt ctaggtgcag gtggatttga tacctcaata   2400

caaggctggg gactagaaga tgtagatctc tacaataaag tcattctatc tggcttaagg   2460

ccattcagaa gccaagaagt aggagtggtg catattttcc atccagttca ttgtgatcct   2520

aacttggacc ctaagcagta taagatgtgc ttaggatcca aggcaagtac tttcgcctca   2580

accatgcaac tggctgaact ctggcttgaa aaacatttag gtgtcaggta caatcgaact   2640

ctctcctgac agtccaggca acacattttg ccttttttaa ggggagttta cctcattgtt   2700

ggttgttgtt atttttattg tattattgtt attttattat tattattgtt ataattttat   2760

tttgttgtcc tggtcttaaa ctactcttgg ttgtcttcct aagggtgttt gttgacctca   2820

agcaagaaga gtctgcagtt cactgatgtt tcagatttct actgaagtca atatgttatt   2880

acttttatat aactttattt gagattgagt taaatcatag caatcaaatg acttttgaaa   2940

cgcattcatc acaagagaca gcttagaaga atgttctctt ggggcttaaa gatgcaatat   3000

cgacttttat ttggtttctc aaattcaatg tgatacaaat atttactggt gaaaggtacc   3060

acaaaagtgc tttatgcttc ctatggggaa gggactctgt aacataaact tgagttttgt   3120

aatttataca aggacttaaa tatataaaca ataattttct tcatctttag aatttttaaa   3180

gtaaatgaat acctatgatt gtatgtttat tttttaaaaa aagttttaaa aattgaggag   3240

ttttgttcca caagcaaccg gtactggcta ccctggtctt atgacaatta tgagctcctc   3300

acaactgtct gctataaatg cgaatgaact ttattttctc aaggaaatat gatttaatta   3360

aatattcatg tacattttag aagctttatg aaacaatgtc cttcatttgc tggcaagaag   3420

ataaaatatg acagaacctg tttatttaaa ataaaacaca ggtatagcag tattcttttt   3480

caaaaacact gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                     3523


<210>  1110
<211>  882
<212>  PRT
<213>  Homosapiens

<400>  1110

Met Ala Val Arg Ser Arg Arg Pro Trp Met Ser Val Ala Leu Gly Leu 
1               5                   10                  15      


Val Leu Gly Phe Thr Ala Ala Ser Trp Leu Ile Ala Pro Arg Val Ala 
            20                  25                  30          


Glu Leu Ser Glu Arg Lys Arg Arg Gly Ser Ser Leu Cys Ser Tyr Tyr 
        35                  40                  45              


Gly Arg Ser Ala Ala Gly Pro Arg Ala Gly Ala Gln Gln Pro Leu Pro 
    50                  55                  60                  


Gln Pro Gln Ser Arg Pro Arg Gln Glu Gln Ser Pro Pro Pro Ala Arg 
65                  70                  75                  80  


Gln Asp Leu Gln Gly Pro Pro Leu Pro Glu Ala Ala Pro Gly Ile Thr 
                85                  90                  95      


Ser Phe Arg Ser Ser Pro Trp Gln Gln Pro Pro Pro Leu Gln Gln Arg 
            100                 105                 110         


Arg Arg Gly Arg Glu Pro Glu Gly Ala Thr Gly Leu Pro Gly Ala Pro 
        115                 120                 125             


Ala Ala Glu Gly Glu Pro Glu Glu Glu Asp Gly Gly Ala Ala Gly Gln 
    130                 135                 140                 


Arg Arg Asp Gly Arg Pro Gly Ser Ser His Asn Gly Ser Gly Asp Gly 
145                 150                 155                 160 


Gly Ala Ala Ala Pro Ser Ala Arg Pro Arg Asp Phe Leu Tyr Val Gly 
                165                 170                 175     


Val Met Thr Ala Gln Lys Tyr Leu Gly Ser Arg Ala Leu Ala Ala Gln 
            180                 185                 190         


Arg Thr Trp Ala Arg Phe Ile Pro Gly Arg Val Glu Phe Phe Ser Ser 
        195                 200                 205             


Gln Gln Pro Pro Asn Ala Gly Gln Pro Pro Pro Pro Leu Pro Val Ile 
    210                 215                 220                 


Ala Leu Pro Gly Val Asp Asp Ser Tyr Pro Pro Gln Lys Lys Ser Phe 
225                 230                 235                 240 


Met Met Ile Lys Tyr Met His Asp His Tyr Leu Asp Lys Tyr Glu Trp 
                245                 250                 255     


Phe Met Arg Ala Asp Asp Asp Val Tyr Ile Lys Gly Asp Lys Leu Glu 
            260                 265                 270         


Glu Phe Leu Arg Ser Leu Asn Ser Ser Lys Pro Leu Tyr Leu Gly Gln 
        275                 280                 285             


Thr Gly Leu Gly Asn Ile Glu Glu Leu Gly Lys Leu Gly Leu Glu Pro 
    290                 295                 300                 


Gly Glu Asn Phe Cys Met Gly Gly Pro Gly Met Ile Phe Ser Arg Glu 
305                 310                 315                 320 


Val Leu Arg Arg Met Val Pro His Ile Gly Glu Cys Leu Arg Glu Met 
                325                 330                 335     


Tyr Thr Thr His Glu Asp Val Glu Val Gly Arg Cys Val Arg Arg Phe 
            340                 345                 350         


Gly Gly Thr Gln Cys Val Trp Ser Tyr Glu Met Gln Gln Leu Phe His 
        355                 360                 365             


Glu Asn Tyr Glu His Asn Arg Lys Gly Tyr Ile Gln Asp Leu His Asn 
    370                 375                 380                 


Ser Lys Ile His Ala Ala Ile Thr Leu His Pro Asn Lys Arg Pro Ala 
385                 390                 395                 400 


Tyr Gln Tyr Arg Leu His Asn Tyr Met Leu Ser Arg Lys Ile Ser Glu 
                405                 410                 415     


Leu Arg Tyr Arg Thr Ile Gln Leu His Arg Glu Ser Ala Leu Met Ser 
            420                 425                 430         


Lys Leu Ser Asn Thr Glu Val Ser Lys Glu Asp Gln Gln Leu Gly Val 
        435                 440                 445             


Ile Pro Ser Phe Asn His Phe Gln Pro Arg Glu Arg Asn Glu Val Ile 
    450                 455                 460                 


Glu Trp Glu Phe Leu Thr Gly Lys Leu Leu Tyr Ser Ala Ala Glu Asn 
465                 470                 475                 480 


Gln Pro Pro Arg Gln Ser Leu Ser Ser Ile Leu Arg Thr Ala Leu Asp 
                485                 490                 495     


Asp Thr Val Leu Gln Val Met Glu Met Ile Asn Glu Asn Ala Lys Ser 
            500                 505                 510         


Arg Gly Arg Leu Ile Asp Phe Lys Glu Ile Gln Tyr Gly Tyr Arg Arg 
        515                 520                 525             


Val Asn Pro Met His Gly Val Glu Tyr Ile Leu Asp Leu Leu Leu Leu 
    530                 535                 540                 


Tyr Lys Arg His Lys Gly Arg Lys Leu Thr Val Pro Val Arg Arg His 
545                 550                 555                 560 


Ala Tyr Leu Gln Gln Leu Phe Ser Lys Pro Phe Phe Arg Glu Thr Glu 
                565                 570                 575     


Glu Leu Asp Val Asn Ser Leu Val Glu Ser Ile Asn Ser Glu Thr Gln 
            580                 585                 590         


Ser Phe Ser Phe Ile Ser Asn Ser Leu Lys Ile Leu Ser Ser Phe Gln 
        595                 600                 605             


Gly Ala Lys Glu Met Gly Gly His Asn Glu Lys Lys Val His Ile Leu 
    610                 615                 620                 


Val Pro Leu Ile Gly Arg Tyr Asp Ile Phe Leu Arg Phe Met Glu Asn 
625                 630                 635                 640 


Phe Glu Asn Met Cys Leu Ile Pro Lys Gln Asn Val Lys Leu Val Ile 
                645                 650                 655     


Ile Leu Phe Ser Arg Asp Ser Gly Gln Asp Ser Ser Lys His Ile Glu 
            660                 665                 670         


Leu Ile Lys Gly Tyr Gln Asn Lys Tyr Pro Lys Ala Glu Met Thr Leu 
        675                 680                 685             


Ile Pro Met Lys Gly Glu Phe Ser Arg Gly Leu Gly Leu Glu Met Ala 
    690                 695                 700                 


Ser Ala Gln Phe Asp Asn Asp Thr Leu Leu Leu Phe Cys Asp Val Asp 
705                 710                 715                 720 


Leu Ile Phe Arg Glu Asp Phe Leu Gln Arg Cys Arg Asp Asn Thr Ile 
                725                 730                 735     


Gln Gly Gln Gln Val Tyr Tyr Pro Ile Ile Phe Ser Gln Tyr Asp Pro 
            740                 745                 750         


Lys Val Thr Asn Gly Gly Asn Pro Pro Thr Asp Asp Tyr Phe Ile Phe 
        755                 760                 765             


Ser Lys Lys Thr Gly Phe Trp Arg Asp Tyr Gly Tyr Gly Ile Thr Cys 
    770                 775                 780                 


Ile Tyr Lys Ser Asp Leu Leu Gly Ala Gly Gly Phe Asp Thr Ser Ile 
785                 790                 795                 800 


Gln Gly Trp Gly Leu Glu Asp Val Asp Leu Tyr Asn Lys Val Ile Leu 
                805                 810                 815     


Ser Gly Leu Arg Pro Phe Arg Ser Gln Glu Val Gly Val Val His Ile 
            820                 825                 830         


Phe His Pro Val His Cys Asp Pro Asn Leu Asp Pro Lys Gln Tyr Lys 
        835                 840                 845             


Met Cys Leu Gly Ser Lys Ala Ser Thr Phe Ala Ser Thr Met Gln Leu 
    850                 855                 860                 


Ala Glu Leu Trp Leu Glu Lys His Leu Gly Val Arg Tyr Asn Arg Thr 
865                 870                 875                 880 


Leu Ser 
        


<210>  1111
<211>  6463
<212>  DNA
<213>  Homosapiens

<400>  1111
ctctcttgct cgctcgctcc ctctctctcc tgctggctgc ctgttctagg aagccagcgc     60

ggagaggggg gggatgcaca gcacagggga gagagattgc gcatgttggt cagtcgtgtt    120

ttaaagagta cagtgcgggg aggctgagag gggcgcatgc aacaacaact tttggaagga    180

tggaagagaa gaggcgaaaa tactccatca gcagtgacaa ctctgacacc actgacagtc    240

atgcgacatc tacatccgca tcaagatgct ccaaactgcc cagcagcacc aagtcgggct    300

ggccccgaca gaacgaaaag aagccctccg aggttttccg gacagacttg atcacagcca    360

tgaagatccc ggactcatac cagctcagcc cggatgacta ctacatcctg gcagacccat    420

ggcgacagga atgggagaaa ggtgtgcagg tgcctgccgg ggcagaggcc atcccagagc    480

ccgtggtgag gatcctccca ccactggaag gcccccctgc ccaggcatcc ccgagcagca    540

ccatgcttgg tgagggctcc cagcctgatt ggccaggggg cagccgctat gacttggacg    600

agattgatgc ctactggctg gagctcatca actcggagct taaggagatg gagaggccgg    660

agctggacga gctgacatta gagcgtgtgc tggaggagct ggagaccctg tgccaccaga    720

atatggccag ggccattgag acgcaggagg ggctgggcat cgagtacgac gaggatgttg    780

tctgcgacgt gtgtcgctct cctgagggcg aggatggcaa cgagatggtc ttctgtgaca    840

agtgcaacgt ctgtgtgcat caggcatgct acgggatcct caaggtgccc acgggcagct    900

ggctgtgccg gacgtgtgcc ctgggtgtcc agccaaagtg cctgctctgc cccaagcgag    960

gaggagcctt gaagcccact agaagtggga ccaagtgggt gcatgtcagc tgtgccctat   1020

ggattcctga ggtcagcatc ggctgcccag agaagatgga gcccatcacc aagatctcgc   1080

atatcccagc cagccgctgg gctctgtcct gcagcctctg caaggaatgc acaggcacct   1140

gcatccagtg ttccatgcct tcctgcgtca cagcgttcca tgtcacatgc gcctttgacc   1200

acggcctgga aatgcggact atattagcag acaacgatga ggtcaagttc aagtcattct   1260

gccaggagca cagtgacggg ggcccacgta atgagcccac atctgagccc acggaaccca   1320

gccaggctgg cgaggacctg gaaaaggtga ccctgcgcaa gcagcggctg cagcagctag   1380

aggaggactt ctacgagctg gtggagccgg ctgaggtggc tgagcggctg gacctggctg   1440

aggcactggt cgacttcatc taccagtact ggaagctgaa gaggaaagcc aatgccaacc   1500

agccgctgct gacccccaag accgacgagg tggacaacct ggcccagcag gagcaggacg   1560

tcctctaccg ccgcctgaag ctcttcaccc atctgcggca ggacctagag agggttagaa   1620

atctgtgcta catggtgaca aggcgcgaga gaacgaaaca cgccatctgc aaactccagg   1680

agcagatatt ccacctgcag atgaaactta ttgaacagga tctgtgtcga ggcctgtcca   1740

cctcattccc catcgatggc accttcttca acagctggct ggcacagtcg gtgcagatca   1800

cagcagagaa catggccatg agcgagtggc cactgaacaa tgggcaccgc gaggaccctg   1860

ctccagggct gctgtcagag gaactgctgc aggacgagga gacactgctc agcttcatgc   1920

gggacccctc gctgcgacct ggtgaccctg ctaggaaggc ccgaggccgc acccgcctgc   1980

ctgccaagaa gaaaccacca ccaccaccac cgcaggacgg gcctggttca cggacgactc   2040

cagacaaagc ccccaagaag acctggggcc aggatgcagg cagtggcaag gggggtcaag   2100

ggccacctac caggaagcca ccacgtcgga catcttctca cttgccgtcc agccctgcag   2160

ccggggactg tcccatccta gccacccctg aaagcccccc gccactggcc cctgagaccc   2220

cggacgaggc agcctcagta gctgctgact cagatgtcca agtgcctggc cctgcagcaa   2280

gccctaagcc tttgggccgg ctccggccac cccgcgagag caaggtaacc cggagattgc   2340

cgggtgccag gcctgatgct gggatgggac caccttcagc tgtggctgag aggcccaagg   2400

tcagcctgca ttttgacact gagactgatg gctacttctc tgatggggag atgagcgact   2460

cagatgtaga ggccgaggac ggtggggtgc agcggggtcc ccgggaggca ggggcagagg   2520

aggtggtccg catgggcgta ctggcctcct aactcacccc cttccctgtc ccaggccctg   2580

ccctggtccc cccacaaggc ctcagcccag tcacaactgc catttccagt ctctgctgag   2640

tgtcccagac cctcgaggct gccactccgt cgtggtttta tttttaatat agagagagtt   2700

ttgaattcta cactgttgtc tttcctctgt gctggcctag gacattagga ttccttccac   2760

ggctccggcc gctaggaccc tgccaggtcc cgcgcaccat ccctgccctg cccacgtggt   2820

attgctgggc tcctggctag atgcaagcaa ggtggacaag agctcaggac tccagcccac   2880

tgccactggg tgacacagac tgtcgtttgg gcattatttc atggcagatg ggccagtcca   2940

gggcctaccc cgccttgccc ccagatccca ctggggtcca tttggggggt cctgctacac   3000

tccaccgatc cccaaggaag tataataaac gatacccagc cagagtctac tcactgtcac   3060

aagcacaacg agtttatatg agaaagcact gagggggtgc agagggcccg ctagttccag   3120

gggaactgaa agctgttcct gatcagcccg tatcatctga ggcctgcctg cccaccctgc   3180

caccctcccc tcccttgctg ctctgcccct gccagtgccc agcccagcgg ctctgggaag   3240

gggttcccag aatccctcct gagctgtgcc atttactcag gggactccca aacagccagc   3300

tgccagtgca ggtggagggc tgtaggggag ggccagtgcc cagacagggt catggggctc   3360

agaccagccc actgtagaga atcactctga ggctccaact tccttccttc cttcggggcc   3420

agtctcggcc gaagtctggt cacgctcaga cagagctgac cagaccagac cgtttgcctt   3480

ttcaagtttc ctagtcctgc tacaagatga gcttcttccg tggtttcctt ttggaaactc   3540

ctccttccaa caagcagtgg gatcccgggg cccagggcgg gccggtgttg gccgctgggg   3600

ctgttgtaag tcttgctgga tgttcccctg ttcctgagcc ttaacccctc gcacagccat   3660

cccccccccc gtcctgccat ccccccccgc cgtcctgcct tccccacccc acccttaggt   3720

cccaggtagt tgctctgaag agtttcagta gagtggcccc agggtgatag ctcagggaac   3780

aacaaaaaag gaattccgtg aaaacatttt tttttctttg atgaattact cctgggtcac   3840

ttccaccact ggtaaagcca gaacttctcc aaaaagaacc ttgcaaaaag tccagtgaat   3900

cagtcgaatc attctgtgga tgccaaagaa tattttgacc ataatacagc acagcctgga   3960

cctgacaact tgtcatttgg actttttttt aaatggagtt ctttagcaac aaagtataga   4020

aacatgttca ttgcacacac ccaaggagaa gagctcaagc gcttggaaga ggatgctttg   4080

ctgctgctga agtgtacctg ggtgttagat ttcagatcct gggctgagcc cactgtgagc   4140

tttcctaaac tgtgagactc acagagggga aagatactga cggtgaaacc agcatggaaa   4200

acgtctttac catgtggttc cctcctcccc aaatacataa agcaaataag caggatgggg   4260

aacagcttga ccttcatcca cccctaactc caaaactatc aaggtacgac agtggcattg   4320

tcatcgacac tcaatttcat gtgaatttta gcaaaacagg aaacaaagat aatgactcag   4380

ttcagaggat cggacaaatg tgtctagtcc gggtggactc ggagggagtg gggtgggctt   4440

caaggattct gggcgttggg atggcatgag ctaccctgta gagtttagtc tgcctgcccg   4500

ccttggtagt agtgaccagt cagtgtcagc atcagtgtcc caaccccagt ctctgtttac   4560

tgcctttgaa cagaacttct tccttcccca tgctttgggt cacctcgggc tgcaaccctg   4620

tctgtgccag attgcccggt ctgaccctgc aggaagcaaa gaggtgagct taaagaacaa   4680

ccaaactctg ccaggggtcc cagaaagccc agggtccagc agtctcagca cttggcccct   4740

tgccccttca caccatcctg gggcaggggc tgggcctccc tggtggcagg ggtgggtgga   4800

gaattaggga gagggtgcaa cgagtctggc cccttgcctc gggctggctg gtgttcttcc   4860

aagagcctct gctcacattg ttggcctctg gattctggcc cttcttcatt ggctgttgct   4920

ttggactgga ctgttgctga gcctgtgtcc tgcagaaccc agatgtctgt taggctggct   4980

ggctgctgcg aggggagggg ggtggccttt catttggggt gccctttcac tcccaggcca   5040

agccctggag caatcttctt caggcagctg tctccacctc caggatgtcc agcaggctgc   5100

aaggagaagg atgccagcca cccatcctcc cccagttccc agcctttccc ctgttggtca   5160

cagccgcttc tgtctttttc cggtctactg tccccagtgt agagggcttt gctgtccctg   5220

agactgaggc aggttccttt tccaggtcag aggtggaggt agatctttct ctcaaccaca   5280

tctgcctcca cacacagctc ctccgcaggg aaggagaagc tgctctgtaa ctcattctgg   5340

ctatcgtccc ccttctcact gacctgaccg cccaccacct ccttccccct catcacatga   5400

caaaggataa tgtgcaagaa aagtattttt atgtatcata aatgtatttt gaaacaaatg   5460

agaagaagaa aggtagaagg gtttatttta ttaaatgagc ctgacttagt gacagtgtgt   5520

gagcatttgc aatgtaaggg cctcagcttc cttggagaag ccaccccagg tttccagaca   5580

tagatgttga attgtttgtg gggggtgtgc caggccacgt ctcgtgtgtc cgtatgcagg   5640

catgcctgtg tatactgtgt atgggcacac tgggactagc tgggacaatt cctagagatt   5700

caactgccca attctaacca acattggcag cggctgaact tggcatttcc ttgctaactg   5760

ccagatgtgg ccaacctttg tccatatgca aaccactgaa aaatgatctg gatttctata   5820

gcaaggccct tggggagggc actctcccat gcccttggcc tcgctggcca cattggccaa   5880

tgagccaggg ctggagtctg agacctttgg ttgttcttta aggcacctcc tgccactttc   5940

tccctcagag gcacaaacac tttgtgttcc acgtcagttt gaggggacgg tggggggatg   6000

atatgaatgt cacaggagga gacaccttct gtctttgttt caaagaaagt gatgtgccat   6060

ttgttaatat acaagagaaa tattgaaaat atattgaaaa gagcaatttt aaattatttt   6120

tggcttatgt tgcaatattt attttcttgt attagaaaag attcctttgt agagaaaaaa   6180

tgtatttttc attaacgcaa agacctattt ctcctttttg tacattgtcc atgtgcgcaa   6240

cccttaacga gcaatagaat gtatggtcac ctgggtgtgg ccagtgcccg ctgtgccctg   6300

catgattctg tgttgccgct gctgcatagt tcccagcccc atcctgtcct gctcactcat   6360

gggggcttcc agaccccggc cccaccaggg cttgtgtcat agggagccct ttgcactcct   6420

cgtgtgttgg caaacgcagt taataaagca gtgttttctg tgc                     6463


<210>  1112
<211>  790
<212>  PRT
<213>  Homosapiens

<400>  1112

Met Glu Glu Lys Arg Arg Lys Tyr Ser Ile Ser Ser Asp Asn Ser Asp 
1               5                   10                  15      


Thr Thr Asp Ser His Ala Thr Ser Thr Ser Ala Ser Arg Cys Ser Lys 
            20                  25                  30          


Leu Pro Ser Ser Thr Lys Ser Gly Trp Pro Arg Gln Asn Glu Lys Lys 
        35                  40                  45              


Pro Ser Glu Val Phe Arg Thr Asp Leu Ile Thr Ala Met Lys Ile Pro 
    50                  55                  60                  


Asp Ser Tyr Gln Leu Ser Pro Asp Asp Tyr Tyr Ile Leu Ala Asp Pro 
65                  70                  75                  80  


Trp Arg Gln Glu Trp Glu Lys Gly Val Gln Val Pro Ala Gly Ala Glu 
                85                  90                  95      


Ala Ile Pro Glu Pro Val Val Arg Ile Leu Pro Pro Leu Glu Gly Pro 
            100                 105                 110         


Pro Ala Gln Ala Ser Pro Ser Ser Thr Met Leu Gly Glu Gly Ser Gln 
        115                 120                 125             


Pro Asp Trp Pro Gly Gly Ser Arg Tyr Asp Leu Asp Glu Ile Asp Ala 
    130                 135                 140                 


Tyr Trp Leu Glu Leu Ile Asn Ser Glu Leu Lys Glu Met Glu Arg Pro 
145                 150                 155                 160 


Glu Leu Asp Glu Leu Thr Leu Glu Arg Val Leu Glu Glu Leu Glu Thr 
                165                 170                 175     


Leu Cys His Gln Asn Met Ala Arg Ala Ile Glu Thr Gln Glu Gly Leu 
            180                 185                 190         


Gly Ile Glu Tyr Asp Glu Asp Val Val Cys Asp Val Cys Arg Ser Pro 
        195                 200                 205             


Glu Gly Glu Asp Gly Asn Glu Met Val Phe Cys Asp Lys Cys Asn Val 
    210                 215                 220                 


Cys Val His Gln Ala Cys Tyr Gly Ile Leu Lys Val Pro Thr Gly Ser 
225                 230                 235                 240 


Trp Leu Cys Arg Thr Cys Ala Leu Gly Val Gln Pro Lys Cys Leu Leu 
                245                 250                 255     


Cys Pro Lys Arg Gly Gly Ala Leu Lys Pro Thr Arg Ser Gly Thr Lys 
            260                 265                 270         


Trp Val His Val Ser Cys Ala Leu Trp Ile Pro Glu Val Ser Ile Gly 
        275                 280                 285             


Cys Pro Glu Lys Met Glu Pro Ile Thr Lys Ile Ser His Ile Pro Ala 
    290                 295                 300                 


Ser Arg Trp Ala Leu Ser Cys Ser Leu Cys Lys Glu Cys Thr Gly Thr 
305                 310                 315                 320 


Cys Ile Gln Cys Ser Met Pro Ser Cys Val Thr Ala Phe His Val Thr 
                325                 330                 335     


Cys Ala Phe Asp His Gly Leu Glu Met Arg Thr Ile Leu Ala Asp Asn 
            340                 345                 350         


Asp Glu Val Lys Phe Lys Ser Phe Cys Gln Glu His Ser Asp Gly Gly 
        355                 360                 365             


Pro Arg Asn Glu Pro Thr Ser Glu Pro Thr Glu Pro Ser Gln Ala Gly 
    370                 375                 380                 


Glu Asp Leu Glu Lys Val Thr Leu Arg Lys Gln Arg Leu Gln Gln Leu 
385                 390                 395                 400 


Glu Glu Asp Phe Tyr Glu Leu Val Glu Pro Ala Glu Val Ala Glu Arg 
                405                 410                 415     


Leu Asp Leu Ala Glu Ala Leu Val Asp Phe Ile Tyr Gln Tyr Trp Lys 
            420                 425                 430         


Leu Lys Arg Lys Ala Asn Ala Asn Gln Pro Leu Leu Thr Pro Lys Thr 
        435                 440                 445             


Asp Glu Val Asp Asn Leu Ala Gln Gln Glu Gln Asp Val Leu Tyr Arg 
    450                 455                 460                 


Arg Leu Lys Leu Phe Thr His Leu Arg Gln Asp Leu Glu Arg Val Arg 
465                 470                 475                 480 


Asn Leu Cys Tyr Met Val Thr Arg Arg Glu Arg Thr Lys His Ala Ile 
                485                 490                 495     


Cys Lys Leu Gln Glu Gln Ile Phe His Leu Gln Met Lys Leu Ile Glu 
            500                 505                 510         


Gln Asp Leu Cys Arg Gly Leu Ser Thr Ser Phe Pro Ile Asp Gly Thr 
        515                 520                 525             


Phe Phe Asn Ser Trp Leu Ala Gln Ser Val Gln Ile Thr Ala Glu Asn 
    530                 535                 540                 


Met Ala Met Ser Glu Trp Pro Leu Asn Asn Gly His Arg Glu Asp Pro 
545                 550                 555                 560 


Ala Pro Gly Leu Leu Ser Glu Glu Leu Leu Gln Asp Glu Glu Thr Leu 
                565                 570                 575     


Leu Ser Phe Met Arg Asp Pro Ser Leu Arg Pro Gly Asp Pro Ala Arg 
            580                 585                 590         


Lys Ala Arg Gly Arg Thr Arg Leu Pro Ala Lys Lys Lys Pro Pro Pro 
        595                 600                 605             


Pro Pro Pro Gln Asp Gly Pro Gly Ser Arg Thr Thr Pro Asp Lys Ala 
    610                 615                 620                 


Pro Lys Lys Thr Trp Gly Gln Asp Ala Gly Ser Gly Lys Gly Gly Gln 
625                 630                 635                 640 


Gly Pro Pro Thr Arg Lys Pro Pro Arg Arg Thr Ser Ser His Leu Pro 
                645                 650                 655     


Ser Ser Pro Ala Ala Gly Asp Cys Pro Ile Leu Ala Thr Pro Glu Ser 
            660                 665                 670         


Pro Pro Pro Leu Ala Pro Glu Thr Pro Asp Glu Ala Ala Ser Val Ala 
        675                 680                 685             


Ala Asp Ser Asp Val Gln Val Pro Gly Pro Ala Ala Ser Pro Lys Pro 
    690                 695                 700                 


Leu Gly Arg Leu Arg Pro Pro Arg Glu Ser Lys Val Thr Arg Arg Leu 
705                 710                 715                 720 


Pro Gly Ala Arg Pro Asp Ala Gly Met Gly Pro Pro Ser Ala Val Ala 
                725                 730                 735     


Glu Arg Pro Lys Val Ser Leu His Phe Asp Thr Glu Thr Asp Gly Tyr 
            740                 745                 750         


Phe Ser Asp Gly Glu Met Ser Asp Ser Asp Val Glu Ala Glu Asp Gly 
        755                 760                 765             


Gly Val Gln Arg Gly Pro Arg Glu Ala Gly Ala Glu Glu Val Val Arg 
    770                 775                 780                 


Met Gly Val Leu Ala Ser 
785                 790 


<210>  1113
<211>  1377
<212>  DNA
<213>  Homosapiens

<400>  1113
ccggaagggg ctgatgcgaa ctggggccac ggcagccatc gcgctttgca gttcggtctc     60

ctggtgtacg gccaacgcca agtaggggat tgcgttccct ccagtcgcag agtttccctc    120

ttgtcgccca ggctggagtg aagtggcacg atctcggctt actgcaagct ccgcctcccg    180

ggttcacgcc attctcctgc ctcagcctcc cgagtagctg ggactacaga ccctatcaga    240

tttggatatg tccttcatat ttgattggat ttacagtggt ttcagcagtg tgctacagtt    300

tttaggatta tataagaaaa ctggtaaact ggtatttctt ggattggata atgcaggaaa    360

aacaacattg ctacacatgc taaaagatga cagacttgga caacatgtcc caacattaca    420

tcccacttcc gaagaactga ccattgctgg catgacgttt acaacttttg atctgggtgg    480

acatgttcaa gctcgaagag tgtggaaaaa ctaccttcct gctatcaatg gcattgtatt    540

tctggtggat tgtgcagacc acgaaaggct gttagagtca aaagaagaac ttgattcact    600

aatgacagat gaaaccattg ctaatgtgcc tatactgatt cttgggaata agatcgacag    660

acctgaagcc atcagtgaag agaggttgcg agagatgttt ggtttatatg gtcagacaac    720

aggaaagggg agtatatctc tgaaagaact gaatgcccga cccttagaag ttttcatgtg    780

tagtgtgctc aaaagacaag gttacggaga aggcttccgc tggatggcac agtacattga    840

ttaacacaaa ctcacattgg ttccaggtct caacgttcag gcttactcag agatttgatt    900

gctcaacatg cataacttga attcaataga cttttgctgg ttataaaaca gatgtttttt    960

agattattaa tattaaatca acttaatttg aatgagaatt gaaaactgat tcaagtaagt   1020

ttgagtatca caatgttagc tttctaattc cataaaagta cttggttttt acagtttata   1080

atctgacatc accccagcgc catttgtaaa gagcaacttt ccagcagtac atttgaagca   1140

ctttttaaca acatgaaact ataaaccata tttaaaagct catcatgtta aattttttat   1200

gtacttttct ggaactagtt tttaaatttt agattatatg tccacctatc ttaagtgtac   1260

agttaataat tagcttattc aatgattgca tgatgcctta cagttttcaa taactttttt   1320

tcttatgcaa acgtcatgca ataaaacaaa ctctaatgtt tggcaaaaaa aaaaaaa      1377


<210>  1114
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  1114

Met Ser Phe Ile Phe Asp Trp Ile Tyr Ser Gly Phe Ser Ser Val Leu 
1               5                   10                  15      


Gln Phe Leu Gly Leu Tyr Lys Lys Thr Gly Lys Leu Val Phe Leu Gly 
            20                  25                  30          


Leu Asp Asn Ala Gly Lys Thr Thr Leu Leu His Met Leu Lys Asp Asp 
        35                  40                  45              


Arg Leu Gly Gln His Val Pro Thr Leu His Pro Thr Ser Glu Glu Leu 
    50                  55                  60                  


Thr Ile Ala Gly Met Thr Phe Thr Thr Phe Asp Leu Gly Gly His Val 
65                  70                  75                  80  


Gln Ala Arg Arg Val Trp Lys Asn Tyr Leu Pro Ala Ile Asn Gly Ile 
                85                  90                  95      


Val Phe Leu Val Asp Cys Ala Asp His Glu Arg Leu Leu Glu Ser Lys 
            100                 105                 110         


Glu Glu Leu Asp Ser Leu Met Thr Asp Glu Thr Ile Ala Asn Val Pro 
        115                 120                 125             


Ile Leu Ile Leu Gly Asn Lys Ile Asp Arg Pro Glu Ala Ile Ser Glu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Met Phe Gly Leu Tyr Gly Gln Thr Thr Gly Lys 
145                 150                 155                 160 


Gly Ser Ile Ser Leu Lys Glu Leu Asn Ala Arg Pro Leu Glu Val Phe 
                165                 170                 175     


Met Cys Ser Val Leu Lys Arg Gln Gly Tyr Gly Glu Gly Phe Arg Trp 
            180                 185                 190         


Met Ala Gln Tyr Ile Asp 
        195             


<210>  1115
<211>  1258
<212>  DNA
<213>  Homosapiens

<400>  1115
ccggaagggg ctgatgcgaa ctggggccac ggcagccatc gcgctttgca gttcggtctc     60

ctggtgtacg gccaacgcca agtaggggat tgcgttccct ccagtcgcag accctatcag    120

atttggatat gtccttcata tttgattgga tttacagtgg tttcagcagt gtgctacagt    180

ttttaggatt atataagaaa actggtaaac tggtatttct tggattggat aatgcaggaa    240

aaacaacatt gctacacatg ctaaaagatg acagacttgg acaacatgtc ccaacattac    300

atcccacttc cgaagaactg accattgctg gcatgacgtt tacaactttt gatctgggtg    360

gacatgttca agctcgaaga gtgtggaaaa actaccttcc tgctatcaat ggcattgtat    420

ttctggtgga ttgtgcagac cacgaaaggc tgttagagtc aaaagaagaa cttgattcac    480

taatgacaga tgaaaccatt gctaatgtgc ctatactgat tcttgggaat aagatcgaca    540

gacctgaagc catcagtgaa gagaggttgc gagagatgtt tggtttatat ggtcagacaa    600

caggaaaggg gagtatatct ctgaaagaac tgaatgcccg acccttagaa gttttcatgt    660

gtagtgtgct caaaagacaa ggttacggag aaggcttccg ctggatggca cagtacattg    720

attaacacaa actcacattg gttccaggtc tcaacgttca ggcttactca gagatttgat    780

tgctcaacat gcataacttg aattcaatag acttttgctg gttataaaac agatgttttt    840

tagattatta atattaaatc aacttaattt gaatgagaat tgaaaactga ttcaagtaag    900

tttgagtatc acaatgttag ctttctaatt ccataaaagt acttggtttt tacagtttat    960

aatctgacat caccccagcg ccatttgtaa agagcaactt tccagcagta catttgaagc   1020

actttttaac aacatgaaac tataaaccat atttaaaagc tcatcatgtt aaatttttta   1080

tgtacttttc tggaactagt ttttaaattt tagattatat gtccacctat cttaagtgta   1140

cagttaataa ttagcttatt caatgattgc atgatgcctt acagttttca ataacttttt   1200

ttcttatgca aacgtcatgc aataaaacaa actctaatgt ttggcaaaaa aaaaaaaa     1258


<210>  1116
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  1116

Met Ser Phe Ile Phe Asp Trp Ile Tyr Ser Gly Phe Ser Ser Val Leu 
1               5                   10                  15      


Gln Phe Leu Gly Leu Tyr Lys Lys Thr Gly Lys Leu Val Phe Leu Gly 
            20                  25                  30          


Leu Asp Asn Ala Gly Lys Thr Thr Leu Leu His Met Leu Lys Asp Asp 
        35                  40                  45              


Arg Leu Gly Gln His Val Pro Thr Leu His Pro Thr Ser Glu Glu Leu 
    50                  55                  60                  


Thr Ile Ala Gly Met Thr Phe Thr Thr Phe Asp Leu Gly Gly His Val 
65                  70                  75                  80  


Gln Ala Arg Arg Val Trp Lys Asn Tyr Leu Pro Ala Ile Asn Gly Ile 
                85                  90                  95      


Val Phe Leu Val Asp Cys Ala Asp His Glu Arg Leu Leu Glu Ser Lys 
            100                 105                 110         


Glu Glu Leu Asp Ser Leu Met Thr Asp Glu Thr Ile Ala Asn Val Pro 
        115                 120                 125             


Ile Leu Ile Leu Gly Asn Lys Ile Asp Arg Pro Glu Ala Ile Ser Glu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Met Phe Gly Leu Tyr Gly Gln Thr Thr Gly Lys 
145                 150                 155                 160 


Gly Ser Ile Ser Leu Lys Glu Leu Asn Ala Arg Pro Leu Glu Val Phe 
                165                 170                 175     


Met Cys Ser Val Leu Lys Arg Gln Gly Tyr Gly Glu Gly Phe Arg Trp 
            180                 185                 190         


Met Ala Gln Tyr Ile Asp 
        195             


<210>  1117
<211>  2203
<212>  DNA
<213>  Homosapiens

<400>  1117
gtgggaaggg gacgcgcgcc ctgcggcccg gcctctagtc atcgccctcg cagcggcggc     60

caacatcacc gccactgcca cccctcccag actgtggacg ggaggatgga gtcgatggcc    120

gtcgctaccg acggcgggga gaggccgggg gtcccagcgg gctcaggtct gtcggcttcc    180

cagcgtcggg cggagctgcg tcggagaaag ctgctcatga actcggaaca gcgcatcaac    240

cggatcatgg gctttcacag gcccgggagc ggcgcggaag aagaaagtca aacaaaatca    300

aagcagcagg acagtgataa actgaactcc ctcagcgttc cttccgtttc aaagcgagta    360

gtgctgggtg attcagtcag tacaggaaca actgaccagc agggtggtgt ggccgaggta    420

aaggggaccc aactgggaga caaattggac tcgttcatta aaccacctga gtgcagtagt    480

gatgtcaacc ttgagctccg gcagcggaac agaggggacc tgacagcgga ctcggtccag    540

aggggttccc gccatggcct agagcagtac ctttccagat tcgaagaagc aatgaagcta    600

aggaaacagc tgattagtga aaaacccagt caagaggatg gaaatacaac agaagaattt    660

gactcttttc gaatatttag attggtggga tgtgctcttc ttgctcttgg agtcagagct    720

tttgtttgca aatacttgtc catatttgct ccatttctta ctttacaact tgcgtacatg    780

ggattataca aatattttcc caagagtgaa aagaagataa agacaacagt actaacagct    840

gcacttctat tgtcgggaat tcctgccgaa gtgataaatc gatcaatgga tacctatagc    900

aaaatgggcg aagtcttcac agatctctgt gtctactttt tcacttttat cttttgtcat    960

gaactgcttg attattgggg ctctgaagta ccatgaagcc tgtagaactg agaaggagaa   1020

gcttacaaaa aaaaaaaaat cctcttctat attgcagtgt ctctaaagga ggcaaattgg   1080

tttacacctt catgtaattc ttttacttta ggggttgtaa agctacttta ttagatatag   1140

aatggcagat tctctgattt aaaagggctg agtttgtatt attactgata tgaagaatag   1200

agtaccaatg tcattaattg atttttcttg ttaatcagaa ttcctattct gtacctttcc   1260

tctaacttct cagatttgta attcttcttt tgggagctga gctagtgctt ttaggagaac   1320

agataaatgt ggtctcagcc agccctagag actgcttctt gtgtttgtgt cattctgtcc   1380

tgagaaatga agtcatctga aaaataaaat gaaagaaact gaattgtcta atgttaactc   1440

tgcacattgt aacttttctt gttgagttag tatcttaatt tttactccag cacaagtatt   1500

taatcaaaga aaagattcat acatgtgaaa ttggaaggta tttataaaat ttttattgct   1560

gtataccaaa ctcagaattg gaacttttta catttgagtt tcacttttta gaagtatgtt   1620

ttaagcaagc aaaaacaaaa tgggatgtga agaattgagg catgcaaccc aatagcataa   1680

atgtcctttt tccccccaaa tatggtctag atgagttatt ataaacattg tttttatttt   1740

tttgagacag agtttcgctc ttgttgccca ggctagagtg caatggcgcc atctcggctc   1800

accgcaacct ccaccttcct ggttcaaggg attctcctgc ctcagcctcc caagtagctg   1860

ggattacagg catgcaccac cacgcccagc taatttttat attctttagt aaagacaggg   1920

tttctccatg ttggtcaggc tggtctcgaa cttctgacct caggtgatct gcccacctcg   1980

gcctcccaaa gtgctgggat tacaggcgtg agccactgca cctggcctta taaatatcct   2040

tttaactaac tcagtaactg ccatattttg ttgggttgtc ttcttaaaag aatataagac   2100

taaagtgtta atgtcacttg gtgttacatt tccttacaga tttttgtata gtctaatttg   2160

gttaatcctt gtgacattaa aaacacatac actttttaaa aaa                     2203


<210>  1118
<211>  296
<212>  PRT
<213>  Homosapiens

<400>  1118

Met Glu Ser Met Ala Val Ala Thr Asp Gly Gly Glu Arg Pro Gly Val 
1               5                   10                  15      


Pro Ala Gly Ser Gly Leu Ser Ala Ser Gln Arg Arg Ala Glu Leu Arg 
            20                  25                  30          


Arg Arg Lys Leu Leu Met Asn Ser Glu Gln Arg Ile Asn Arg Ile Met 
        35                  40                  45              


Gly Phe His Arg Pro Gly Ser Gly Ala Glu Glu Glu Ser Gln Thr Lys 
    50                  55                  60                  


Ser Lys Gln Gln Asp Ser Asp Lys Leu Asn Ser Leu Ser Val Pro Ser 
65                  70                  75                  80  


Val Ser Lys Arg Val Val Leu Gly Asp Ser Val Ser Thr Gly Thr Thr 
                85                  90                  95      


Asp Gln Gln Gly Gly Val Ala Glu Val Lys Gly Thr Gln Leu Gly Asp 
            100                 105                 110         


Lys Leu Asp Ser Phe Ile Lys Pro Pro Glu Cys Ser Ser Asp Val Asn 
        115                 120                 125             


Leu Glu Leu Arg Gln Arg Asn Arg Gly Asp Leu Thr Ala Asp Ser Val 
    130                 135                 140                 


Gln Arg Gly Ser Arg His Gly Leu Glu Gln Tyr Leu Ser Arg Phe Glu 
145                 150                 155                 160 


Glu Ala Met Lys Leu Arg Lys Gln Leu Ile Ser Glu Lys Pro Ser Gln 
                165                 170                 175     


Glu Asp Gly Asn Thr Thr Glu Glu Phe Asp Ser Phe Arg Ile Phe Arg 
            180                 185                 190         


Leu Val Gly Cys Ala Leu Leu Ala Leu Gly Val Arg Ala Phe Val Cys 
        195                 200                 205             


Lys Tyr Leu Ser Ile Phe Ala Pro Phe Leu Thr Leu Gln Leu Ala Tyr 
    210                 215                 220                 


Met Gly Leu Tyr Lys Tyr Phe Pro Lys Ser Glu Lys Lys Ile Lys Thr 
225                 230                 235                 240 


Thr Val Leu Thr Ala Ala Leu Leu Leu Ser Gly Ile Pro Ala Glu Val 
                245                 250                 255     


Ile Asn Arg Ser Met Asp Thr Tyr Ser Lys Met Gly Glu Val Phe Thr 
            260                 265                 270         


Asp Leu Cys Val Tyr Phe Phe Thr Phe Ile Phe Cys His Glu Leu Leu 
        275                 280                 285             


Asp Tyr Trp Gly Ser Glu Val Pro 
    290                 295     


<210>  1119
<211>  5695
<212>  DNA
<213>  Homosapiens

<400>  1119
agcacgtcct gttttcgttg gccgcgctgg gatggccgcc acagctgtag gtgctgctag     60

tgtttagcgc tggtctttgc cgggcgttga gggcagctca gcctccttgt ttgtccggtt    120

cgcctgtgcg tggtactcaa gggcaccagt attcccgcgg tcggcagcat gggtcgggag    180

tcacgccact atcgaaaacg atcggcatcc cggggtcgct ctggaagtcg gtctagaagt    240

cgctcaccct cagacaaaag aagtaaacgt ggagatgaca gacggtctag aagtagagat    300

agagatagga ggagagagag gtctcgtagc agggataaaa gaagatctcg gtcaagggac    360

aggaagcgtc tgagacgttc cagaagtaga gagagagaca gaagccgaga gcgaagaaga    420

tctcgaagta gagacaggag acgctcaagg agtagaagcc ggggccggcg atcccgatcc    480

tccagtcctg gaaataaaag caagaaaact gagaatagat ctaggtccaa agagaaaact    540

gatggtgggg aaagttctaa agagaagaaa aaagacaaag atgacaagga ggatgaaaaa    600

gaaaaagatg ctggcaactt tgaccagaat aagctggaag aagaaatgag aaagcgaaaa    660

gaaagagtag aaaaatggcg agaagagcaa cgtaaaaagg ctatggaaaa cataggagaa    720

ctgaaaaagg aaatcgaaga gatgaaacaa gggaaaaagt ggagtttaga ggacgatgat    780

gatgacgaag atgatcctgc agaagctgaa aaggagggaa atgaaatgga gggtgaggag    840

ttagatccat tagatgctta catggaagaa gtgaaagagg aagtaaaaaa atttaacatg    900

agaagtgtaa aaggtggtgg gggaaatgaa aagaagtctg ggccaacggt cacaaaagtt    960

gtcactgttg tgacaaccaa aaaagcagtt gtggattctg ataagaagaa aggtgagctg   1020

atggagaatg accaggatgc catggagtat tcttcagagg aggaagaagt tgatcttcag   1080

acagccctta cagggtatca aacaaaacag cgaaagcttc tagaaccagt tgatcatgga   1140

aaaattgagt atgagccatt taggaaaaac ttctatgttg aagttccaga actagcaaaa   1200

atgtctcaag aagaggtaaa tgtgtttcga ttggaaatgg agggcattac agttaaagga   1260

aaaggttgcc ccaaaccaat taaatcctgg gtccagtgtg gaatttccat gaagatctta   1320

aattccctca agaagcatgg ctatgaaaag cccacgccca tccaaaccca agctattcct   1380

gctataatgt ctggacgaga tttgattggc attgccaaaa caggaagtgg aaagaccatt   1440

gcttttctgt tgcccatgtt tagacacatc atggatcaga ggtcattaga ggaaggagag   1500

gggccaatag ctgtcatcat gactccaact cgagaactgg ctttacagat tactaaagag   1560

tgtaagaagt tttccaagac tttgggactt agagtggtct gtgtttacgg aggaacagga   1620

atcagtgagc agattgctga gctgaaaaga ggtgctgaaa ttattgtttg cacacctggt   1680

cgaatgattg acatgttagc cgctaacagt ggtcgggtca caaatcttcg aagagtgaca   1740

tatgttgttt tagatgaagc agacagaatg tttgacatgg gttttgaacc ccaggtcatg   1800

cgcatcgtgg ataatgttcg tcctgatcga cagacggtta tgttttcagc tactttcccc   1860

agagctatgg aggctttggc tcgcaggatc ctcagtaaac ctattgaagt acaagttgga   1920

ggcaggagtg tggtttgctc agatgtggag caacaagtga ttgtgattga agaagaaaag   1980

aaattcttga agttacttga gcttctaggc cattatcaag agtcaggatc tgtcattata   2040

tttgtggata agcaggaaca tgctgatggt cttcttaagg atttaatgag agcatcttat   2100

ccttgcatgt ctcttcatgg aggcattgat caatatgaca gagatagcat cataaatgac   2160

tttaagaatg ggacctgcaa acttcttgtg gctacctctg ttgctgcccg aggtctagat   2220

gtgaaacatc tgattcttgt agtaaattat agctgcccca accattatga ggattatgta   2280

cacagagcag ggcggactgg aagagcagga aacaagggtt atgcttatac ttttatcaca   2340

gaggatcaag ctcgctatgc tggtgacata attaaagctc ttgaattgtc agggactgca   2400

gtacctcctg atttagagaa actgtggagt gatttcaaag atcagcagaa agctgagggg   2460

aaaataatta aaaagagtag tgggttctct ggtaagggat tcaagtttga tgaaacagaa   2520

caagctttgg ctaatgagag gaagaagtta caaaaagcag ctcttggtct acaagattca   2580

gatgatgagg atgctgcagt tgatattgat gagcaaattg aaagcatgtt taattcaaag   2640

aagagagtaa aggatatggc tgctcctgga acatcaagtg ttcctgctcc aactgcagga   2700

aatgctgaga aattagaaat tgctaagaga ttggctctta gaatcaatgc ccagaagaat   2760

ttgggcatcg agtctcagga tgtgatgcag caggccacca atgcaattct taggggtggc   2820

accattctgg ctcccactgt ttctgcaaaa accattgcag aacaacttgc tgaaaagatc   2880

aatgccaagc tcaattatgt gccgttagag aaacaagaag aagagagaca ggatggtgga   2940

cagaatgaat cttttaagag atatgaagaa gaattagaga tcaatgactt cccacagact   3000

gctaggtgga aagttacctc taaggaagct ctgcagagaa tcagtgaata ctctgaagcc   3060

gcaattacaa tcagaggaac ctacttccct cctggcaaag aacccaagga aggcgagcgg   3120

aagatttact tggcaattga aagtgccaat gaactggctg tgcagaaagc aaaggcagaa   3180

atcaccaggc tcataaaaga agagctgatc cggctgcaaa attcatacca accaacaaat   3240

aaaggaagat acaaagtctt atagacatcc ggaaaaaaga tttttacctg tgctggtcta   3300

tgatgtatgt ggcagttgct gtctgcagtt tacaatgtat tgtaaatgaa gattttttaa   3360

attctatctt gctgattttt tttaaatata agaaactggt acttggtaaa gaaatctgtc   3420

cgtaagtacc cccacaatca gtcaaactat atttaaagcc agcctgtttt cagagtatga   3480

tgtcctttaa tgtaaactca aatatcaata ttttaaatgt ccggataata ttctagaggt   3540

ttaaaaaatg gaaatatttg aactttctat tgaagacaat aaagtacaca agtcgttaag   3600

gggctattca ctttatcctg tactttcaat gaaattgtga tcatttccta agaaaaggta   3660

aaattcacta tcatattttg tgtccccacc ttgatgttac atgactctgg aacaatatga   3720

actggattta agaatgttat aatagaagtc ttacaaaatg ggttgagagt ttttgtttca   3780

atttttatca tcataaatgg gcaaaaagta gttggactaa tttcggtttt tatacaagta   3840

aagatttaat agtataagga tttttttgca tttctttaca ctgagtgtaa aactctacaa   3900

agagttatag tatttactac tttgaggttt ccctcacaac ttctggctcc atacctagcc   3960

cctcttttat aatcttcctt aaaagaaaga gtgtagccta taaatactaa atatgatacc   4020

ttttccttct agaaagtgtt tatttatata tctatacatg ttgtatgtac aaatatccta   4080

ctacttttaa tctgattttt cttcaggatt attgagtagg ttgtgaattt tctttcttaa   4140

aaattgtaaa acataatggt acccaagttt taaacttaga tgtgcttcat cttagtgaaa   4200

tttaattcac aaggaatcat aaattgtgtt tttgaggctg ggcgcagtga ctcacacctg   4260

tatcccagca atttgggagg ccgaggtggg cagatcactt gaggtcagga gttcaagact   4320

agcctggtca acatggtgaa accctgtctc tactaaaaat acaaaaatta gtcggcatgg   4380

tggtgggtgg ctgtaatccc agctactcag gaggctgagg cagaagaatc tgagccaaga   4440

taacaccatt gcactccagc ctgggcgaca gagtgagact atctcaaaaa taaataaata   4500

aataaataaa tagtattttt gagccttcaa gatacagttc ctgaatattc taatttaaat   4560

tgttataatt ggattaccta atattctttt caagactcct gatgtattaa cttcatgtta   4620

ttgtcacttt tcaaaaaagg aatttttttc aggagttaaa taaagtcagt cttttatatc   4680

caagggtttc aaacccacag attaaaccaa ccacagatca aaaatagaaa aaaaaaaaaa   4740

aagaaaaaaa gaatgtaaaa ttttaaaaat acagtttaac agctgtaaaa gttttactat   4800

aacatttaca ttgtgttagg tattttaagt aatttaaagg ttacagtata caggcggtta   4860

aagtatacag gaggatgtgc atcggttata tgcatatagc aagccatttc atataagagg   4920

cttgaacatc catggatttt ggtatagagg aggggtttaa ggggtgtcct gcaatcagtc   4980

cccctctcat accaaaggat gactgtatat ttcttaaatg aagagacttt cattctttaa   5040

atattattga cttacagttt aaaaataaat aaataaaagc atactatagt tgtaaaaaca   5100

aataatttta atagtatatt cagtggctga agtgataggg agtattaatc attatttctt   5160

cagtataaag ttattcttcc tgaaaaagta agatatacct gggaaatatt cttggatcct   5220

tcacacatcc acttaatttc ttgaaggaag aaaacagaca aaagacatgt aacaacagaa   5280

acaaataaac cacttactgt aaaatttcag aaattgtggg ctcattccct ccctctagtt   5340

tatttatttg ctcatcttta tcacctaatg gtagtttgtt ttctttggta gagtatatgg   5400

cagtcccaca tcgatgataa ttggtgctcc cttcatccaa ctggatcact ttgagattca   5460

gttttacatc attttagcat tttgtttgta tatcagttgt gatgagccac tgataaaatt   5520

ttgttctaaa atgaaacata ttactttgtt agtacatttt ttagtgtcac actgactttt   5580

aaaatttgaa tgatatatag actttgtttt tttaatgcaa tatgaatatt tgctcatgtt   5640

ttctaaattc cttataaaat aaaattaatt cgaattcaaa aaaaaaaaaa aaaaa        5695


<210>  1120
<211>  1031
<212>  PRT
<213>  Homosapiens

<400>  1120

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
1               5                   10                  15      


Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
            20                  25                  30          


Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
        35                  40                  45              


Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
    50                  55                  60                  


Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
65                  70                  75                  80  


Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                85                  90                  95      


Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Asn Lys Ser Lys 
            100                 105                 110         


Lys Thr Glu Asn Arg Ser Arg Ser Lys Glu Lys Thr Asp Gly Gly Glu 
        115                 120                 125             


Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
    130                 135                 140                 


Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
145                 150                 155                 160 


Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                165                 170                 175     


Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
            180                 185                 190         


Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
        195                 200                 205             


Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Gly Glu Glu 
    210                 215                 220                 


Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
225                 230                 235                 240 


Lys Phe Asn Met Arg Ser Val Lys Gly Gly Gly Gly Asn Glu Lys Lys 
                245                 250                 255     


Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
            260                 265                 270         


Ala Val Val Asp Ser Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
        275                 280                 285             


Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
    290                 295                 300                 


Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
305                 310                 315                 320 


Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                325                 330                 335     


Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
            340                 345                 350         


Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
        355                 360                 365             


Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
    370                 375                 380                 


Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
385                 390                 395                 400 


Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                405                 410                 415     


Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
            420                 425                 430         


His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
        435                 440                 445             


Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
    450                 455                 460                 


Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
465                 470                 475                 480 


Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                485                 490                 495     


Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
            500                 505                 510         


Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
        515                 520                 525             


Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
    530                 535                 540                 


Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
545                 550                 555                 560 


Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                565                 570                 575     


Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
            580                 585                 590         


Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
        595                 600                 605             


Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
    610                 615                 620                 


Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
625                 630                 635                 640 


Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                645                 650                 655     


Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
            660                 665                 670         


Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
        675                 680                 685             


Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
    690                 695                 700                 


His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
705                 710                 715                 720 


Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                725                 730                 735     


Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
            740                 745                 750         


Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
        755                 760                 765             


Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
    770                 775                 780                 


Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
785                 790                 795                 800 


Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                805                 810                 815     


Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
            820                 825                 830         


Pro Gly Thr Ser Ser Val Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
        835                 840                 845             


Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
    850                 855                 860                 


Leu Gly Ile Glu Ser Gln Asp Val Met Gln Gln Ala Thr Asn Ala Ile 
865                 870                 875                 880 


Leu Arg Gly Gly Thr Ile Leu Ala Pro Thr Val Ser Ala Lys Thr Ile 
                885                 890                 895     


Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val Pro 
            900                 905                 910         


Leu Glu Lys Gln Glu Glu Glu Arg Gln Asp Gly Gly Gln Asn Glu Ser 
        915                 920                 925             


Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln Thr 
    930                 935                 940                 


Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser Glu 
945                 950                 955                 960 


Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro Gly 
                965                 970                 975     


Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu Ser 
            980                 985                 990         


Ala Asn Glu Leu Ala Val Gln Lys  Ala Lys Ala Glu Ile  Thr Arg Leu 
        995                 1000                 1005             


Ile Lys  Glu Glu Leu Ile Arg  Leu Gln Asn Ser Tyr  Gln Pro Thr 
    1010                 1015                 1020             


Asn Lys  Gly Arg Tyr Lys Val  Leu 
    1025                 1030     


<210>  1121
<211>  4269
<212>  DNA
<213>  Homosapiens

<400>  1121
aagaaatggg gtcagcagga gttccagcat ctcagaattg tggtgaaaac caatacaaaa     60

aatgatgcat cctgttgcca gcagtaatcc agctttctgt gggcctggca agccttcctg    120

cctcaatgaa gatgccatga gagctgctga tcagtttgac atatattcct cccagcaaag    180

caaatacagc cacacagtca accacaaacc aatggtttgt cagaggcaag acccattaaa    240

tgaaacacac ttgcagacta caagtggcag aagcatagaa ataaaagatg aactaaagaa    300

aaagaagaat ctcaaccgat ctggtaagcg tggccggcct tcgggaacca ccaaatcagc    360

aggataccgg accagcacag gcagacccct gggaaccacc aaagcagctg gatttaagac    420

aagtccaggc agacctttgg ggacaactaa agctgcggga tacaaagtca gcccaggcag    480

acctccaggt agcattaaag ctctatcccg tcttgccgat cttggttatg gctgtggcac    540

tgctgctttt ccttacccta tgatgcatgg cagagcagtt catggggtag aggaaactag    600

cagtgaagtc aaaccaccca atgagtgaat gaggcaggaa aagagggcca ggtttagaag    660

gaagattgtg aataatccca aagcttcttg gttttatttt gatatacata attttatggc    720

ctgggctttc caaatttgtt ttcctgtttg gtttttttcc tgcttttgct caaaaactgc    780

catatgctga cagatgcact cagggcatga gcagcggcat tgtatttgta cataggttca    840

agtgtaacac ctaactaaat catttttcct tttcctttag agttatggtc atgtctcatg    900

tttcattact actttggggc tgttctaaat agatgcttta tgtgataaac aactgaaacc    960

attataccta ttagtttgtg aagtaagcct acagtataat aaagacacta acgtattttt   1020

aactgatgga gcaaaaaagc aaactaatga atcaggatta cttgaggtaa tggctgtgtg   1080

agtttttgta acatttattt tcacaagatg ggacacatat ttgtatgctt tggcatttac   1140

atccacttca aatgttaaaa aacttatttt taatgtttta ggtttaagca gcttgtaatt   1200

tattgatcta catggcatta attgatttaa ccattatacc tgaaataatt cttcagtgtt   1260

tgcctttgag cagtgatagg ttgtgtattt tttaattgcc taagagcata tataccaaac   1320

actacaaaca attcatattt acagaaaatt taaactattt tataaaaact gcacattaca   1380

tttttggtga aatatagtgc attctgagga tagcatattt catataatag aaaaagaagc   1440

attctctagg tttgcatgta gctatagtca ctatattttg cctttcatat agaaagtttt   1500

aaagtattat gtttaaaaac atttattggc tgggtgtggt ggctcacacc cagcactttg   1560

ggaggccgag gcaggcggat cacttgaggt cagcagttca agactagcct ggccaacatg   1620

gtgaaacccc atctctacta aaaatataaa aattagccag gcgtggtggc gggcgcctgt   1680

aatccaagct actggggagg ctgaggcagg agaattgctt aaatccagga ggcggaggtt   1740

gcagtgagcc aagattgtgc cactgcactc cagcctgggt gacagagtaa gactccgtct   1800

caaataaata aataaataaa taaataaata aataaataaa accatttatt gatgttgctc   1860

atttatttgg aacgttttta gtttttctca gaaattgtcc cattgcatta gcacttactg   1920

tgttttcagg ttgatatcta ccaaaggaca caaattgaat ggtagactgt aaaactggta   1980

taaacagaat gcagtttccc gaccatcaga acccaaatat taagaagcat ataggaatcc   2040

atctatgcat gaaacatgta aaaaatatgt tggttagttt aattaaaaat cttattgtgg   2100

gtccagtgag accatctcat ccaaaagatt ttttttcccc caatgatgtt tgctttagaa   2160

gcaagataga aaggaaaaaa agtattaggt agatatgtat agtagggaca gagggaaatc   2220

tttcttcttt cctttctgaa agtaatactt cttgttacac attttattta ttgagtttgt   2280

tctaaataaa atattataaa cttcagactt gaaaaaattc cacttaactt taaagttaca   2340

atgtttgtat ttgggatttt aaatgccttt gagattaaaa tgtagaattg caggacccaa   2400

aaacttttaa aataattaaa attttaaaag agcacatgtt gtgttttttg ggcttgctat   2460

taatgcaaac tctgattgca aatggatgtc atgtttcata ccttttttat caggaaaaaa   2520

gcagcaagcc ttcaggtgtt ccagtgatgc ctgacacaat tgagctggac tttatgctgc   2580

tctttacagt aagaggtgtt gcattgtatg tggggactat gtgcactggc gtctaagaca   2640

gtgacctcaa caatattagc tttgcacaaa ccatagagaa cgatgttgga tggttacata   2700

atcagttata acattctggc agctaaattg ctacaagagc tttttcttgc aaaagcttaa   2760

aatacaagat ttttaataat ttactcagaa cagtataact tctgacacac acaaatgctt   2820

gcctctttat tcatatgttc gttacctact ctgtacatgt atctgtcatt tagctgtttc   2880

tcaagatgat gttcagcagt tggctgctta gaaatctttt tcaagccagt ttctaaagac   2940

atttgtttaa tgttctacca tagaataatg cacaccattg tcaaagattt gattattgtg   3000

ttttatagta agtccatttg acatttattt ccctttcagt ttattttcct tccttatttt   3060

gttatacata cccttccctt tctcccctgc ctttcgtaca ttcattcctc ttcctctacc   3120

ctccagcaca tctacttact ggtgctgtgc tgtgtgtcag aagataaaac aggtgtatta   3180

ttgtataatg aattttgtat acatgtttat gaaatggtga gatcaactaa aggaggcatg   3240

ttcataacag tgtttattat cagcagctat gtcccaggaa aaaaaaatgg gaggggcaaa   3300

tggctacagt tgtaaatgga taacatcatt tagaaagccg aatttactgt tcatctgagc   3360

ggttacctgg agtattatat ctatgcactg gtgagcatct cctgattcca cttacttttc   3420

tccctgtgaa cagtttaccg gtgccatgct gaagagaaag acatctaagt gataacatga   3480

atgaagtctt aaaatttaaa gtatttttac tgctatataa actaaagact acattgtgca   3540

tattttgtta acactgtctc ttgttatgat aaacactgaa atagcatgtt aaacagttgc   3600

ctatacttta atataatcag ttggggaaaa ctggcctttt ctcccccact gtatgattgt   3660

ttcttgaaag gtaaattgct aattttatac agtgtaattc tgttcttcac aaaataggtt   3720

tcattattct atatttaaac tgttggtcag aaaatgatct gcaattcaag taagtctgca   3780

ttactttttt ctttaaaaag tactttaaca tgccttattt attatattag caaatgagct   3840

aataacagat gaaattttca ttttttgaca gatataacct tgcataagta gtatttaggg   3900

tgattttgat actatcttta gagttttgca ttggatatta aaaaatatat tggcacaatg   3960

tattggaaga aaatgagtag tatctggttt aatttttaat atttagggac attttaaaaa   4020

atcaatgttt taattagact aaaaattctt tatatttttt atttactttt taaagaaaca   4080

tctgtcaaag taatattgat tccaaactga tgtttgtgtg aatttacatg tctattttca   4140

tgaactaaga atagagtttc tttgagttga ggagaaaaaa atatatatgt gggtccattt   4200

attaggttaa agttgaccca ttcagtgtaa aaataaccat agtgtgtgag ctaaaaaaaa   4260

aaaaaaaaa                                                           4269


<210>  1122
<211>  188
<212>  PRT
<213>  Homosapiens

<400>  1122

Met Met His Pro Val Ala Ser Ser Asn Pro Ala Phe Cys Gly Pro Gly 
1               5                   10                  15      


Lys Pro Ser Cys Leu Asn Glu Asp Ala Met Arg Ala Ala Asp Gln Phe 
            20                  25                  30          


Asp Ile Tyr Ser Ser Gln Gln Ser Lys Tyr Ser His Thr Val Asn His 
        35                  40                  45              


Lys Pro Met Val Cys Gln Arg Gln Asp Pro Leu Asn Glu Thr His Leu 
    50                  55                  60                  


Gln Thr Thr Ser Gly Arg Ser Ile Glu Ile Lys Asp Glu Leu Lys Lys 
65                  70                  75                  80  


Lys Lys Asn Leu Asn Arg Ser Gly Lys Arg Gly Arg Pro Ser Gly Thr 
                85                  90                  95      


Thr Lys Ser Ala Gly Tyr Arg Thr Ser Thr Gly Arg Pro Leu Gly Thr 
            100                 105                 110         


Thr Lys Ala Ala Gly Phe Lys Thr Ser Pro Gly Arg Pro Leu Gly Thr 
        115                 120                 125             


Thr Lys Ala Ala Gly Tyr Lys Val Ser Pro Gly Arg Pro Pro Gly Ser 
    130                 135                 140                 


Ile Lys Ala Leu Ser Arg Leu Ala Asp Leu Gly Tyr Gly Cys Gly Thr 
145                 150                 155                 160 


Ala Ala Phe Pro Tyr Pro Met Met His Gly Arg Ala Val His Gly Val 
                165                 170                 175     


Glu Glu Thr Ser Ser Glu Val Lys Pro Pro Asn Glu 
            180                 185             


<210>  1123
<211>  3689
<212>  DNA
<213>  Homosapiens

<400>  1123
agttaaaacc aacctctcct gccctgagtg gataggtagg gttagggttg ccagatgtca     60

cgaagttaca ggatgctcag ttttaaggta tatcccttat actataaggg ttatagtaaa    120

aaatattcat tatgtgaaat tcaaatataa ctgggtatca ggtattctat gtggcaaccc    180

taggtagggg agcacaggtt aggcaagcga ttagaagatt tgcagcctcc aaagtttctg    240

cacctcgatg ggacactaga acaggaaggc tcctgggcct ttctggctct gggaatgaag    300

cgtggaaaac cctccttagg cgggcgcagt gcttcaagta gccaagctct gacttccgag    360

ggaagaaagg aggccatggg cctctgccag agccatgctc tgcactctgg ggtcagcaga    420

gttcaaaacg acctgcaacg tctggcgctt agctcctaaa gaggtctcca gtccagcgcc    480

gacggccagc ggctagaggc cgtccgcccg actccaagat ggcgcccgcc acagctgcca    540

ggtgttaaga tggcggcgcg gggccgcgcc cgcgctccca ggctctcctc ccccagcctt    600

cctccggctg gcagcacgac tcgcgtagcc gtgcgccgat tgcctctcgg cctgggcaat    660

ggtcccggct gccggtcgac gaccgccccg cgtcatgcgg ctcctcggct ggtggcaagt    720

attgctgtgg gtgctgggac ttcccgtccg cggcgtggag gttgcagagg aaagtggtcg    780

cttatggtca gaggagcagc ctgctcaccc tctccaggtg ggggctgtgt acctgggtga    840

ggaggagctc ctgcatgacc cgatgggcca ggacagggca gcagaagagg ccaatgcggt    900

gctggggctg gacacccaag gcgatcacat ggtgatgctg tctgtgattc ctggggaagc    960

tgaggacaaa gtgagttcag agcctagcgg cgtcacctgt ggtgctggag gagcggagga   1020

ctcaaggtgc aacgtccgag agagcctttt ctctctggat ggcgctggag cacacttccc   1080

tgacagagaa gaggagtatt acacagagcc agaagtggcg gaatctgacg cagccccgac   1140

agaggactcc aataacactg aaagtctgaa atccccaaag gtgaactgtg aggagagaaa   1200

cattacagga ttagaaaatt tcactctgaa aattttaaat atgtcacagg accttatgga   1260

ttttctgaac ccaaacggta gtgactgtac tctagtcctg ttttacaccc cgtggtgccg   1320

cttttctgcc agtttggccc ctcactttaa ctctctgccc cgggcatttc cagctcttca   1380

ctttttggca ctggatgcat ctcagcacag cagcctttct accaggtttg gcaccgtagc   1440

tgttcctaat attttattat ttcaaggagc taaaccaatg gccagattta atcatacaga   1500

tcgaacactg gaaacactga aaatcttcat ttttaatcag acaggtatag aagccaagaa   1560

gaatgtggtg gtaactcaag ccgaccaaat aggccctctt cccagcactt tgataaaaag   1620

tgtggactgg ttgcttgtat tttccttatt ctttttaatt agttttatta tgtatgctac   1680

cattcgaact gagagtattc ggtggctaat tccaggacaa gagcaggaac atgtggagta   1740

gtgatggtct gaaagaagtt ggaaagagga acttcaatcc ttcgtttcag aaattagtgc   1800

tacagtttca tacattttct ccagtgacgt gttgacttga aacttcaggc agattaaaag   1860

aatcatttgt tgaacaactg aatgtataaa aaaattataa actggtgttt taactagtat   1920

tgcaataagc aaatgcaaaa atattcaata gatgcactat tcttgttttt actgcatgaa   1980

cgtaatccag tatttggaaa gtaatccagt ttgaaatgtg aagatgtatt ccggcagaat   2040

agtgagtaga atgacatgct tactatacag aaggcaaaaa taggactctc aggtaatagt   2100

ttaaggaaac ccttgattcc ttatatatgt ttaagaaggt tagttttctg tttctttgca   2160

gtttttcttc tagagtccat agcaggaaag tatgtaacca gaattggtta gtgtgacccc   2220

ctcaagtagc aagtgatgga aaataagagt caaatacctt gatgtttgtg atctctaact   2280

caaaaaattt gaagtgtttt aagttgtttc tgggtaaggg agatgttagg agaaaggaaa   2340

tgctgtaact aaagctcaat tattatcagt tctatgctaa cgtatacatt ttaatcatag   2400

ttacctaagc agcatgcatt aattgaacct taaaatgttc ccagcaggct gggcgcagtg   2460

gctcatgcct gtaatcccag cactttggga ggccaaggcg ggaggatcac ttgaggttag   2520

gacttttgag accagcctgg ccaacttggt gaaaccctct ctctactaaa aatacaaaaa   2580

attagctggg cgtggtggcg ggcacctgta atcccagcta cttgggaaag ctgaggcatg   2640

agaatcactt gaacccggga ggcagaggtt gcagtgagct gagatcatgc cactgcactc   2700

cagcctgtgc aaccagagcg aaactccatc tcaaaaacaa acaaaaagaa gtattgaagt   2760

gtaaaacact gttcttgccc acaagttgat tctagtctag ttcaagacac atgtttagta   2820

aagagacaac atgtaattta aacaaacttt tttttttttt ttagacaaag tctcactctg   2880

tcacctaggc tggagtgcaa tggtgcaatc ttggctcact gcaacctctg cttcccgggt   2940

tcaagcgatt ctccagcctc agcctcctga gtagctggga ctatgggcct gtgccatcac   3000

acccagctaa tttttctatt tttagtagag atggggtttt gccatgttgg ccaggctggt   3060

ctcaaactgc tgacttcagg tgatccaccc gcctcagcct cccaaagtgt tgggattaca   3120

ggtgtgagcc actgcgcctg gcctaaacaa actttttgaa aagctgtttc taaaagattc   3180

cttaaattca gatatgacag ctaattacct catcataaat tacttttata ctaattgttt   3240

ccagggtttt agagtagttg aatgtttatt tcacaaggca ccctaaattc tatagaaata   3300

aaacctcaga tgagtctcct tcttagagtg ttacaatgaa tgggagttta caacttttat   3360

gtgtcatgtt tccaacagct gtgtttgggg tggtcactgg caggagggga ccgtatctca   3420

gaatggcaca ttatttctat tttacacatg agcaaattga ggcatagaga gttagataac   3480

ttgcccaggt tacacagatt gtaagttgat gaagctggga tttgaatctt cacatgtgtg   3540

tacttataaa tacaaatgta aggaaaactc tagtgagtcc acctcttata ttgagttatt   3600

actgtgtgag tgccaagtac tgttttagat gctttacata tactattttg tttaatatcc   3660

tttttaaaga ataaactagg ttggtgcag                                     3689


<210>  1124
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  1124

Met Val Pro Ala Ala Gly Arg Arg Pro Pro Arg Val Met Arg Leu Leu 
1               5                   10                  15      


Gly Trp Trp Gln Val Leu Leu Trp Val Leu Gly Leu Pro Val Arg Gly 
            20                  25                  30          


Val Glu Val Ala Glu Glu Ser Gly Arg Leu Trp Ser Glu Glu Gln Pro 
        35                  40                  45              


Ala His Pro Leu Gln Val Gly Ala Val Tyr Leu Gly Glu Glu Glu Leu 
    50                  55                  60                  


Leu His Asp Pro Met Gly Gln Asp Arg Ala Ala Glu Glu Ala Asn Ala 
65                  70                  75                  80  


Val Leu Gly Leu Asp Thr Gln Gly Asp His Met Val Met Leu Ser Val 
                85                  90                  95      


Ile Pro Gly Glu Ala Glu Asp Lys Val Ser Ser Glu Pro Ser Gly Val 
            100                 105                 110         


Thr Cys Gly Ala Gly Gly Ala Glu Asp Ser Arg Cys Asn Val Arg Glu 
        115                 120                 125             


Ser Leu Phe Ser Leu Asp Gly Ala Gly Ala His Phe Pro Asp Arg Glu 
    130                 135                 140                 


Glu Glu Tyr Tyr Thr Glu Pro Glu Val Ala Glu Ser Asp Ala Ala Pro 
145                 150                 155                 160 


Thr Glu Asp Ser Asn Asn Thr Glu Ser Leu Lys Ser Pro Lys Val Asn 
                165                 170                 175     


Cys Glu Glu Arg Asn Ile Thr Gly Leu Glu Asn Phe Thr Leu Lys Ile 
            180                 185                 190         


Leu Asn Met Ser Gln Asp Leu Met Asp Phe Leu Asn Pro Asn Gly Ser 
        195                 200                 205             


Asp Cys Thr Leu Val Leu Phe Tyr Thr Pro Trp Cys Arg Phe Ser Ala 
    210                 215                 220                 


Ser Leu Ala Pro His Phe Asn Ser Leu Pro Arg Ala Phe Pro Ala Leu 
225                 230                 235                 240 


His Phe Leu Ala Leu Asp Ala Ser Gln His Ser Ser Leu Ser Thr Arg 
                245                 250                 255     


Phe Gly Thr Val Ala Val Pro Asn Ile Leu Leu Phe Gln Gly Ala Lys 
            260                 265                 270         


Pro Met Ala Arg Phe Asn His Thr Asp Arg Thr Leu Glu Thr Leu Lys 
        275                 280                 285             


Ile Phe Ile Phe Asn Gln Thr Gly Ile Glu Ala Lys Lys Asn Val Val 
    290                 295                 300                 


Val Thr Gln Ala Asp Gln Ile Gly Pro Leu Pro Ser Thr Leu Ile Lys 
305                 310                 315                 320 


Ser Val Asp Trp Leu Leu Val Phe Ser Leu Phe Phe Leu Ile Ser Phe 
                325                 330                 335     


Ile Met Tyr Ala Thr Ile Arg Thr Glu Ser Ile Arg Trp Leu Ile Pro 
            340                 345                 350         


Gly Gln Glu Gln Glu His Val Glu 
        355                 360 


<210>  1125
<211>  6485
<212>  DNA
<213>  Homosapiens

<400>  1125
tgcagccatg ctgaatcact gttgctgatc agatttccca ctggtctgct gggagaatca     60

agaacagaac taggatcccc gagtgcatac acagttcagc agctaccacc ctggctgggc    120

ctcacacaat ggagggtgaa agtgtcaagc tgagctccca gactctgata caggctgggg    180

atgatgagaa gaaccagagg acgatcactg tcaaccctgc ccacatgggg aaagcattca    240

aggttatgaa tgaactgcgg agtaaacagc tgttgtgtga cgtgatgatt gtggcagaag    300

atgtcgagat agaagcccac cgtgtggtcc tggcagcctg cagcccctac ttctgtgcga    360

tgttcacagg tgacatgtct gagagtaaag ccaaaaagat agaaatcaag gacgtggatg    420

ggcagacgct gagtaagctg attgactaca tctatactgc tgaaatcgag gtgactgaag    480

agaatgtcca ggtgctgctc ccggcagcca gcttgctgca gctcatggat gttcggcaga    540

actgctgtga cttcctgcag tctcagttgc atcccaccaa ttgcctgggc atccgtgcgt    600

ttgcagatgt acacacctgc actgaccttc tgcagcaggc caatgcctac gcagagcagc    660

actttccaga ggtgatgcta ggagaagaat ttcttagcct gagtctggac caggtgtgca    720

gcttgatatc cagcgacaag ctgaccgttt cttcagaaga gaaggtgttt gaagctgtga    780

tctcatggat caattatgag aaagaaaacc gtttagagca catggcaaag ctgatggaac    840

atgtccgact tcctctctta cctagggact acctagtcca aacggttgaa gaagaagctt    900

tgataaagaa taacaacacc tgtaaagact tcctcattga ggccatgaaa taccatctcc    960

tccctctgga tcagagacta ttgattaaga acccaaggac caagcccagg actccagtca   1020

gccttcccaa ggtcatgatt gtggttggcg gccaggcacc caaggcaatc cgcagtgtgg   1080

agtgctatga tttcgaggag gaccggtggg atcagattgc tgagcttcct tccagaagat   1140

gcagagcagg tgtggtgttc atggctggcc acgtgtatgc cgtgggaggg tttaatggct   1200

cactgcgggt gcggacagtg gatgtgtatg acggcgtgaa ggaccagtgg acgtccattg   1260

ccagcatgca ggagcgccgg agcacactgg gcgcagcggt gctcaatgac ttgctctacg   1320

cagtgggagg ctttgatggc agtactggcc tagcatcggt ggaagcctac agctacaaga   1380

ccaacgagtg gttctttgtg gccccgatga acacgcggca gagcagtgtg ggtgtgggcg   1440

ttgtggaggg gaagctatat gctgttgggg gttatgatgg agcttcccgc cagtgtctga   1500

gcactgtgga acagtacaac ccagcgacca atgaatggat atacgtggcg gacatgagca   1560

cccgccgcag tggcgcaggg gttggagtgc ttagcggaca gctgtacgcc acaggtgggc   1620

atgatgggcc tttggtgagg aagagcgttg aggtttacga tcctggaaca aatacctgga   1680

agcaagtggc agacatgaac atgtgccggc gcaacgcagg ggtctgtgca gtaaatgggc   1740

tcctgtatgt ggttggaggg gatgatggat cctgcaactt ggcttcggtg gagtactaca   1800

atcctgtcac tgacaaatgg acgctgcttc caacgaacat gagcacgggg cggagctatg   1860

caggtgttgc cgtgattcac aagtccttgt gacccaaact cctactgcca ggaggtggag   1920

gaaggagcag gtgctgcctg tgactctgaa cagcaggacc ttggtgactg gattcaactt   1980

gcttgggagg gtctgtgctg ctgtgagaac cgctctcctc tgacttggca gactggtgtt   2040

gttcatcgca gtgtggacac cattacccac ccccgttccc ctgaggtgct ctggcctatg   2100

ccctgagcaa ggggggtctt gacatcccca ggcagcacct ttgggctttg ttttggtgtt   2160

tctacaggga caatacagac cctggagtgt gtgtgtgtgt gtgtgtagac catggtgttt   2220

ctctatgttt ctctaagttg gggggtgagc gtgtgtgaca gtctactgga tttctttact   2280

actgatcctt tcgctgtgtt aaaaatcaag tcacagagac ctctcttctg gatttgtccc   2340

atggggaccc tgagactact aaagctgctt tcttctgaag gtccagttgg acagtctggg   2400

aatgtccaga aataaccagt gagaggggca gttctctggc cacacccact tatgtacttt   2460

aactactgtg actttgtctg cagaagagct ggaaaattct cgaagctgca ccgtgtcctc   2520

tgtgtgctag aataagggac aaatgggttc cctgtgcttc tcagctcact gtttttcctt   2580

gagttctcct acaggaagca gatgagaact gcccagtctt caggtttagg ccattggtct   2640

ttgatgtcat agattccagg cctgggaggt gttatgtctc ttcagctggg aaaactagct   2700

cttcagagaa gcctcgggta acactgaaaa acaaaacaaa acaaaacaaa aacaggaaaa   2760

aaacaaaaaa ccaaagtggt aaggattcag ttcctgccta taatggtctc agagagggtc   2820

ctacttttag gttttcccag gacaggacag tccccattta tacttattat cccagtttaa   2880

ttattcacag caccccattt tactcagaag tgttctggtc tggaggataa ataagaggtc   2940

accctcctcc agacccaaag atagatttgt gcctgtgttg gatggggtcg tgtgtgattc   3000

agatggacat tggatggctt caaaggaata taccactaga gctggccctt ggcactttgt   3060

gacagtggtc aagtctgtct aatgtccttg tcttcttttt cttgtgcttt ccccctattc   3120

cagggtgtgc accctctccc caacccccaa gaaccccact actgctttcc ctgtgaggta   3180

ggagatatca gtgggtcttg gatttgaggc ttcctaagat gtgcttgcat tttaaaaagg   3240

gagcttggtg agagctttgc taattcacag gtaaaaatta ttaacaatag aacttcaagc   3300

atcttgagga gcgggcattt gagggggcat ggagtaattt gtatttaaaa aaccttaaag   3360

ttgtgctgtt cctaaactag caaattgctc atgctgaaat ttctggcata agcaggggaa   3420

gtcttgtgtc tggagaatag tctcatacct tgcagtctgg gacaccctcc ctactttgag   3480

aatccaccta caggaagcca aggaacttta taaatcctga tgttggactt ctgatacgac   3540

tgggctactt ccaagcaggt gctgcaggag attggcatcc cccagcccct gcagttagaa   3600

accccgaagt cttcccagcc agtgagccac tttgtgtatt tactgtatat ttattgtgcc   3660

ctaaatgtgc aactctccta aagacaaaac ttctctttct gatgttaagc acatgttact   3720

tcaacaagat gcttggagaa caacaaggta cccagaattt ttagaagcct tcagaagagg   3780

ctaaaatatc cagctttggg ggacctggaa gaaatgtctc caaaggaagc aaggcatgtt   3840

ttagttgagt gctctggtct cactatgaag tggggatgac tgtggcttca taactctacc   3900

tggctgtggg ttggaagctg atggaatgag aaatgtcctt tctccttctc tgaggaaatt   3960

ttgagacttg tttcggtgtg tctgtgtgat ggggatgagg ctggggttgg gatctgatgt   4020

atgccattca cagaagctct caatttcaga tgataggtga attccctgcc cctcccccac   4080

cactgagaag ctagactttc atgcgggaga ggctactttt atgtgtcgtc ttccggggaa   4140

gggtccctcc actgaaagct agccagtcat gttttctgtt tttggatttt tgcaattggt   4200

ttcacctcat gtctccctcc ctacaaagca ctgcctctac tgggcgtgct gccaaggcca   4260

tgtgcactcc atcctcatgt atcctttttc acggggacca gaacactggt acgtcatcac   4320

caaagccaat ctgctctagc tgcccacaga tgccaccaaa acctgctatc tcttcatcac   4380

caggtacgat tctctttcca cagtggacac agcaggctat tttctagttt gtgctggtca   4440

cgtggtagat gaagcctctt actgccccac ttagggtggc cacggctgct tgtgaatgca   4500

gctttgccag tggcatatct gtcatctgat tgcggtggtg aaatggaatt gaggcccaag   4560

gttagaagca gccgagacgc cacttggata ctgatttgaa caatgtagaa gtcagattct   4620

gaattccaaa gttatttctc ataagtaccc aatggcatct ctccatctac aaagttgcag   4680

tattatgcaa ataaaactga cctcattttc tgctatgcaa taagaatact taattctagt   4740

tcccgacaag ccagttgcaa tatcccctaa gatgcttttt gagctgtctt actttgatat   4800

ctgttgtgta acgtttgtat atttctgagc cagatccttt caaagattgc ctttttataa   4860

aattgaagct atagctttta ggctaaaatt ttaacgtaga tatttttata agatattttt   4920

ttcaagagtt tgaatcgctt tttattgtcc atggtaatga aatgttgtgt tctttgcatc   4980

attcactctc aaacgtagtt catgcctgta gctctcttcc ttttgtttct cacccttcag   5040

aaacatattt ttcagtagct ccaggtagat gagccttttt tttttttttt ttaaatacca   5100

tattcaaggg agtctgctga attttaaaac gcagtcactg gtgtttcttg aattgctagg   5160

gactgatgtt atgttcgact cagcacttgc ccgtctgtat tgattgtgtc tttttttttt   5220

tttttggagt ctgctttctg tgggggtgag gccgggctgt ctcgtggtgg ctcccactga   5280

cgggcactga gcctggtacc ctgtggcatg gagaagcctc agggaaaggc ctgccccccc   5340

agcacatact cccatagtgt cctaggtcca gccgaccatt ccttattctc ttctatctcc   5400

ttgttgatct gaagcttcca atagcttgag gcctttgctg ctggatgatg ccctttttgg   5460

gagcatcttg tctctaacct ttaaaagagg ggtcaatcct catgatccct gtgtgttaag   5520

catatgcttt gcaggtgctc acactacact tacaacttgc ttcttgagct atgtctctac   5580

tccaggctct gttttgtgta tttatctgcc atttgcatca tggtttttaa aatttattat   5640

tattattatt attgttggga caggtgccat ttaaattgcc tccatgctcc ccatttgcac   5700

ctagctggat caagttggga ggctgagcaa actcatattc cagttagttg gagtttttaa   5760

aggctctgtt tgcctggaga agcaaggagg ttagaatgta atttttttaa gcgtttgcac   5820

tatttagagt cctaagcccc tcatgttcag ctgtgctgtg tttctactga ccaagcagga   5880

gagccagcag cacttccagc atttgggaat ggaagagatt tcttctgtag tggataatta   5940

cagcctcata gcccctgtgc agccttcgtc atgggactca gtgactcatg gatatagcat   6000

cagccatggc aggaatgcac aggactgtgg catttgcagc atcaaatcac cctagtgcca   6060

tgtttggtta tgagattgta aattattcgc tcccccgtcc tcccctcccc tcattttcag   6120

tggcaataga ggacccttgt tgtacttctt gtttaatttg catattatgt gtaaaatgct   6180

ttcgttgaaa gaaaactgaa gacactgaat gtgtatgtct gtgtgggtgc tctgtccctg   6240

tggttgtcat agccagtcag acttgatcac tgacaccccg tacaacatat tgcataggta   6300

agatcctcga tctggtgttc tctgcgtggc tgttagggac tgtatatctt gtaaaagaac   6360

acttgtcaca tgcttgatca gttacagcaa tagctgaaga aacatttcct caaatgtatt   6420

attttaacag gaatcatgtt ctaatttccc atcctttaat tttaataaaa gctgaactgt   6480

gtgaa                                                               6485


<210>  1126
<211>  587
<212>  PRT
<213>  Homosapiens

<400>  1126

Met Glu Gly Glu Ser Val Lys Leu Ser Ser Gln Thr Leu Ile Gln Ala 
1               5                   10                  15      


Gly Asp Asp Glu Lys Asn Gln Arg Thr Ile Thr Val Asn Pro Ala His 
            20                  25                  30          


Met Gly Lys Ala Phe Lys Val Met Asn Glu Leu Arg Ser Lys Gln Leu 
        35                  40                  45              


Leu Cys Asp Val Met Ile Val Ala Glu Asp Val Glu Ile Glu Ala His 
    50                  55                  60                  


Arg Val Val Leu Ala Ala Cys Ser Pro Tyr Phe Cys Ala Met Phe Thr 
65                  70                  75                  80  


Gly Asp Met Ser Glu Ser Lys Ala Lys Lys Ile Glu Ile Lys Asp Val 
                85                  90                  95      


Asp Gly Gln Thr Leu Ser Lys Leu Ile Asp Tyr Ile Tyr Thr Ala Glu 
            100                 105                 110         


Ile Glu Val Thr Glu Glu Asn Val Gln Val Leu Leu Pro Ala Ala Ser 
        115                 120                 125             


Leu Leu Gln Leu Met Asp Val Arg Gln Asn Cys Cys Asp Phe Leu Gln 
    130                 135                 140                 


Ser Gln Leu His Pro Thr Asn Cys Leu Gly Ile Arg Ala Phe Ala Asp 
145                 150                 155                 160 


Val His Thr Cys Thr Asp Leu Leu Gln Gln Ala Asn Ala Tyr Ala Glu 
                165                 170                 175     


Gln His Phe Pro Glu Val Met Leu Gly Glu Glu Phe Leu Ser Leu Ser 
            180                 185                 190         


Leu Asp Gln Val Cys Ser Leu Ile Ser Ser Asp Lys Leu Thr Val Ser 
        195                 200                 205             


Ser Glu Glu Lys Val Phe Glu Ala Val Ile Ser Trp Ile Asn Tyr Glu 
    210                 215                 220                 


Lys Glu Asn Arg Leu Glu His Met Ala Lys Leu Met Glu His Val Arg 
225                 230                 235                 240 


Leu Pro Leu Leu Pro Arg Asp Tyr Leu Val Gln Thr Val Glu Glu Glu 
                245                 250                 255     


Ala Leu Ile Lys Asn Asn Asn Thr Cys Lys Asp Phe Leu Ile Glu Ala 
            260                 265                 270         


Met Lys Tyr His Leu Leu Pro Leu Asp Gln Arg Leu Leu Ile Lys Asn 
        275                 280                 285             


Pro Arg Thr Lys Pro Arg Thr Pro Val Ser Leu Pro Lys Val Met Ile 
    290                 295                 300                 


Val Val Gly Gly Gln Ala Pro Lys Ala Ile Arg Ser Val Glu Cys Tyr 
305                 310                 315                 320 


Asp Phe Glu Glu Asp Arg Trp Asp Gln Ile Ala Glu Leu Pro Ser Arg 
                325                 330                 335     


Arg Cys Arg Ala Gly Val Val Phe Met Ala Gly His Val Tyr Ala Val 
            340                 345                 350         


Gly Gly Phe Asn Gly Ser Leu Arg Val Arg Thr Val Asp Val Tyr Asp 
        355                 360                 365             


Gly Val Lys Asp Gln Trp Thr Ser Ile Ala Ser Met Gln Glu Arg Arg 
    370                 375                 380                 


Ser Thr Leu Gly Ala Ala Val Leu Asn Asp Leu Leu Tyr Ala Val Gly 
385                 390                 395                 400 


Gly Phe Asp Gly Ser Thr Gly Leu Ala Ser Val Glu Ala Tyr Ser Tyr 
                405                 410                 415     


Lys Thr Asn Glu Trp Phe Phe Val Ala Pro Met Asn Thr Arg Gln Ser 
            420                 425                 430         


Ser Val Gly Val Gly Val Val Glu Gly Lys Leu Tyr Ala Val Gly Gly 
        435                 440                 445             


Tyr Asp Gly Ala Ser Arg Gln Cys Leu Ser Thr Val Glu Gln Tyr Asn 
    450                 455                 460                 


Pro Ala Thr Asn Glu Trp Ile Tyr Val Ala Asp Met Ser Thr Arg Arg 
465                 470                 475                 480 


Ser Gly Ala Gly Val Gly Val Leu Ser Gly Gln Leu Tyr Ala Thr Gly 
                485                 490                 495     


Gly His Asp Gly Pro Leu Val Arg Lys Ser Val Glu Val Tyr Asp Pro 
            500                 505                 510         


Gly Thr Asn Thr Trp Lys Gln Val Ala Asp Met Asn Met Cys Arg Arg 
        515                 520                 525             


Asn Ala Gly Val Cys Ala Val Asn Gly Leu Leu Tyr Val Val Gly Gly 
    530                 535                 540                 


Asp Asp Gly Ser Cys Asn Leu Ala Ser Val Glu Tyr Tyr Asn Pro Val 
545                 550                 555                 560 


Thr Asp Lys Trp Thr Leu Leu Pro Thr Asn Met Ser Thr Gly Arg Ser 
                565                 570                 575     


Tyr Ala Gly Val Ala Val Ile His Lys Ser Leu 
            580                 585         


<210>  1127
<211>  2983
<212>  DNA
<213>  Homosapiens

<400>  1127
gcccagatag gggagcggag gtggcggcgg cggcggtagc ggtggccttg gttgtcttcc     60

agtctcctcg gctcgccctt tagccggcac cgctcccctt ccctccccct tcctctcttc    120

cttccttccc tccccttccc tttttccctt ccccgtcggt gagcggcggg ggtggctcca    180

gcaacggctg ggcccaagct gtgtagaggc cttaaccaac gataacggcg gcgacggcga    240

aacctcggag ctcgcagggc gggggcaagg cccgggcctt ggagatggag aattctcagt    300

tgtgtaagct gttcatcggc ggcctcaatg tgcagacgag tgagtcgggc ctgcgcggcc    360

actttgaggc ctttgggact ctgacggact gcgtggtggt ggtgaatccc cagaccaagc    420

gctcccgttg ctttggcttc gtgacctact ccaatgtgga ggaggcggac gccgccatgg    480

ccgcctcgcc ccatgccgtg gacggcaaca ctgtggagct gaagcgggcg gtgtcccggg    540

aggattcggc gcggcccggt gcccacgcca aggttaagaa gctctttgtc ggaggcctta    600

aaggagacgt ggctgagggc gacctgatcg agcacttctc gcagtttggc accgtggaaa    660

aggccgagat tattgccgac aagcagtccg gcaagaagcg tggattcggc ttcgtgtatt    720

tccagaatca cgacgcggca gacaaggccg cggtggtcaa gttccatccg attcagggcc    780

atcgcgtgga ggtgaagaaa gcagtcccca aggaggatat ctactccggt gggggtggag    840

gcggctcccg atcctcccgg ggcggccgag gcggccgggg gcgcggcggt ggtcgagacc    900

agaacggcct ttccaagggc ggcggcggcg gttacaacag ctacggtggt tacggcggcg    960

gcggaggcgg cggctacaat gcctacggag gcggcggcgg cggttcgtcc tacggtggga   1020

gcgactacgg taacggcttc ggcggcttcg gcagctacag ccagcatcag tcctcctatg   1080

ggcccatgaa gagcggcggc ggcggcggcg gtggaggcag tagctggggc ggtcgcagta   1140

atagtggacc ttacagaggc ggctatggcg gtgggggtgg ctatggaggc agctccttct   1200

aaaagaaaat ttaaaatgcc tgggagtggc tataggggta gctctttcca acagcccaag   1260

tggggtcaac tcctaagccc caccccctca cacacaccgc cttccctgtt ttgcccttgg   1320

gggagccact tctaaggctg cttacccttg ggggtgttcc tctatttgcc tgccacctct   1380

cttgtctctc cctctgaaga tggactcggc cccacataca catttttgtg ttacagtcat   1440

tgatggactc tattttttta ttattacttg gaccttggtc gtttttatac tagcaaaatg   1500

tcttgtttta atttgtgttt tttgggggga gggagggagt gaacttgctg attctgtagc   1560

aaaacctggg tgggggttgg ggtggggggt agtttacttt gttgtaagga cttgataacc   1620

tggctacagc gttttctatg aaatctactt ggatcccatg cctgaaattt ggaagcatat   1680

gtacaaaaat catttttacg ttttattttt aataaatcat tgtgtttgac cgtacatgtc   1740

taacattttt tttctaggat ccattccgta ccgtttttta agggatattt gtttaagact   1800

ttacgtgtta attctttatt cttgatgtgt acttagagaa acttaagagg tcctgtggtt   1860

tttttcccct ctcctgttgc cctgctagtt gcgtgttgaa ttatatccct tacaggcaaa   1920

acttttgaag tggtggatgt ggctttttaa actcttaagt ttctgtgcat ccatctcttg   1980

tactaagcga attgtttatc atcttgacat ggttggtcat ttctatgaca atttacttca   2040

aactgtgtac tgtgtagttc tatatagttt gtgttaagca tgtcattcat ataaactgtt   2100

taaaattttt cagatggcct agtttcatcc ctcttactgg tttgtctgta atgaatggtt   2160

aaaaataagg gttatatttt accctcaaat gcgtttttgt actttcagag caggtttaaa   2220

cgtttttttt ttttttttcc tatatccgaa ctgttggcct catggaaatc cctttcccga   2280

tctttgtagc accatctact ggcagaatgg cagagtagct gcgaaacaat ttgtttaaaa   2340

acttgcttaa gacaattgca tcagatttgg aagttttgcc atcaaaattc tttgcagaat   2400

tggaagttaa cacatttgct tgtaactgag atgggcttca caggaatgta gttgccagtt   2460

catatcacaa tagccctttc tatatgaggt ttgaaaatgt aaactgctat gcatagcttg   2520

ggcaatagcc ctaaattgct atgacaacta atgaaccagc tacgtatact ggtattttag   2580

gtgcaagttg taaagcaaaa tatctgtgta ttctgcttgg ttaacaaatg tatatttgta   2640

gccctttcct gcaatagcat tcaagttgtt gtttataaga gaagaacaaa agtgataata   2700

ggtgaaaatt gcctttctgg atagaaatag agaatagcaa cgtttatgga tatcacaaat   2760

aaagaattca attctttaca tgattgagtg agagtatgta taacctggtg ggtgggttca   2820

gagtaccttt taatctagta tgcttaactt gatgttaata tttaacttaa atatttgact   2880

tacatgttga cgttgaaggc tcaaagctat actaagaagc tttctgaaag attgggcttt   2940

aaaataaaat aatattttaa tattgaaaaa aaaaaaaaaa aaa                     2983


<210>  1128
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  1128

Met Glu Asn Ser Gln Leu Cys Lys Leu Phe Ile Gly Gly Leu Asn Val 
1               5                   10                  15      


Gln Thr Ser Glu Ser Gly Leu Arg Gly His Phe Glu Ala Phe Gly Thr 
            20                  25                  30          


Leu Thr Asp Cys Val Val Val Val Asn Pro Gln Thr Lys Arg Ser Arg 
        35                  40                  45              


Cys Phe Gly Phe Val Thr Tyr Ser Asn Val Glu Glu Ala Asp Ala Ala 
    50                  55                  60                  


Met Ala Ala Ser Pro His Ala Val Asp Gly Asn Thr Val Glu Leu Lys 
65                  70                  75                  80  


Arg Ala Val Ser Arg Glu Asp Ser Ala Arg Pro Gly Ala His Ala Lys 
                85                  90                  95      


Val Lys Lys Leu Phe Val Gly Gly Leu Lys Gly Asp Val Ala Glu Gly 
            100                 105                 110         


Asp Leu Ile Glu His Phe Ser Gln Phe Gly Thr Val Glu Lys Ala Glu 
        115                 120                 125             


Ile Ile Ala Asp Lys Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val 
    130                 135                 140                 


Tyr Phe Gln Asn His Asp Ala Ala Asp Lys Ala Ala Val Val Lys Phe 
145                 150                 155                 160 


His Pro Ile Gln Gly His Arg Val Glu Val Lys Lys Ala Val Pro Lys 
                165                 170                 175     


Glu Asp Ile Tyr Ser Gly Gly Gly Gly Gly Gly Ser Arg Ser Ser Arg 
            180                 185                 190         


Gly Gly Arg Gly Gly Arg Gly Arg Gly Gly Gly Arg Asp Gln Asn Gly 
        195                 200                 205             


Leu Ser Lys Gly Gly Gly Gly Gly Tyr Asn Ser Tyr Gly Gly Tyr Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Tyr Asn Ala Tyr Gly Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Tyr Gly Gly Ser Asp Tyr Gly Asn Gly Phe Gly Gly Phe Gly 
                245                 250                 255     


Ser Tyr Ser Gln His Gln Ser Ser Tyr Gly Pro Met Lys Ser Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Ser Ser Trp Gly Gly Arg Ser Asn Ser Gly 
        275                 280                 285             


Pro Tyr Arg Gly Gly Tyr Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser 
    290                 295                 300                 


Phe 
305 


<210>  1129
<211>  1957
<212>  DNA
<213>  Homosapiens

<400>  1129
ttgataggga tagaaacaca tttggctgct tctatagtta acaagatgct gttacattcc     60

ttgcctcact agctctgaag actatactag cgggacaaag aaagcacctg agatgagctg    120

agaggagggt aaaggtacac agagatcccc tggatatttg ttctatgtcc tctcaggggc    180

tttgctacca ctagagaatt atccatatta agaacttgca ttgatattct gggttctgtt    240

tcatttttta gggtctcaag agcacgctca agtcattcac atgtttccat caaatacaga    300

cacagatcag ggaagattaa accctactaa tttctcgtcg gatgcctcac aacaaggtgc    360

cttccaagaa ctaatggcca aaatatccac ccacaacaca aataagctta gaaaatctct    420

tcttacaatc ctgacacaat ggaagtttcc ctaaaccacc cagcatctaa tacaaccagc    480

acaaagaaca acaactcggc atttttttac tttgagtcct gtcaacctcc ttctccagct    540

ttactcctat tatgcatagc ctatactgtg gtcttaattg tgggcctttt tggaaacctc    600

tctctcatca tcatcatctt taagaagcag agaaaagctc agaatttcac cagcatactg    660

attgccaatc tctccctctc tgataccttg gtgtgtgtca tgtgcatcca ttttactatc    720

atctacactc tgatggacca ctggatattt ggggatacca tgtgcagact cacatcctat    780

gtgcagagtg tctcaatctc tgtgtccata ttctcacttg tattcactgc tgtcgaaaga    840

tatcagctaa ttgtgaaccc ccgtggctgg aagcccagtg tgactcatgc ctactggggc    900

atcacactga tttggctgtt ttcccttctg ctgtctattc ccttcttcct gtcctaccac    960

ctcactgatg agcccttccg caacctctct ctccccactg acctctacac ccaccaggtg   1020

gcctgtgtgg agaactggcc ctccaaaaag gaccggctgc tcttcaccac ctcccttttt   1080

ctgctgcagt attttgttcc tctaggcttc atcctcatct gctacttgaa gattgttatc   1140

tgcctccgca ggagaaatgc aaaggtagat aagaagaagg aaaatgaggg ccggctcaat   1200

gagaacaaga ggatcaacac aatgttgatt tccatcgtgg tgacctttgg agcctgctgg   1260

ctgccccgaa tatcttcaat gtcatctttg actggtatca tgaggtgctg atgagctgcc   1320

accacgacct ggtatttgta gtttgccact tggttgctat ggtttccaca tgtataaacc   1380

ctctctttta tggctttctc aacaaaaatt tccaaaagga cctggtagtg cttattcacc   1440

actgctggtg cttcacacct caggaaagat gtgaaaatat tgccatctcc actatgcaca   1500

cagactccaa gaggtcttta agattggctc gtataacaac aggtatatga aaattgataa   1560

tgctgaagct cttcttgaat gggagctgga caggtaatgg tgggaatagg gcaagatgca   1620

gaaagaagaa accagaacca aaaatagcaa ctttataccc acttttcctt taggctaaga   1680

ctgcctgtct catatgtcta tccaacacac cctccaacat acacgaacac acataccacc   1740

ccttttctct taagaaaata actctaataa ttcaaacaac ctgcccgcca tcatttgtgg   1800

caaagaatga gaatgagaaa gcagagagag aggcaaacag cagtgatggc tggggaacaa   1860

tgttcacaga tacttttatt caatggaata tctacaaaag ttatgactaa tgatatgcct   1920

agtaaaaaca ctgctatacc tccttagcac tgagaat                            1957


<210>  1130
<211>  2244
<212>  DNA
<213>  Homosapiens

<400>  1130
gggaaggaga tgcctcttcc ttcccttcaa tagtgggtta aacccagctg gcaccctctg     60

gaactacggg aacaatattc ttcaagagaa ggtcactcta ccaaagccag gagcacagta    120

ttctcaggat ctcaacaagg aagagcagac caaggttgct tctgattcct tacaaccttc    180

cgtaattcca ggcttgtggc cccaaattca gggccccacc cttccaggaa caaatcatta    240

tagtaataat ttgccttcat cttccatata ccaactaagc atgtttaact acgaacgtcc    300

aaaacacttc atccagtccc aaaacccatg tggctccaga ttgcagcctc ctggaccaga    360

aacctccagc ttctctagcc agaccaaaca gtcttccatt atcatccagc cccgccagtg    420

tacagagcaa agattttctg cctcctcaac actgagctct cacatcacca tgtcctcctc    480

tgctttccct gcttctcccc agcagcatgc tggctccaac ccaggccaaa gggttacaac    540

cacctataac cagtccccag ccagcttcct cagctccata ttaccatcac agcctgatta    600

caatagcagt aaaatccctt ccgctatgga ttccaactat caacagtcct cagctggcca    660

acctataaat gcaaagccat cccaaactgc aaatgctaag cccataccaa gaactcctga    720

tcatgaaata caaggatcaa aagaagcttt gattcaagat ttggaaagaa agctgaaatg    780

caaggacacc cttcttcata atggaaatca acgtctaaca tatgaagaga agatggctcg    840

cagattgcta ggaccacaga atgcagctgc tgtgtttcaa gctcaggatg acagtggtgc    900

acaagactcg cagcaacaca actcagaaca tgcgcgactg caagttccta catcacaagt    960

aagaagtaga tcaacctcaa ggggagatgt gaatgatcag gatgcaatcc aggagaaatt   1020

ttacccacca cgtttcattc aagtgccaga gaacatgtcg attgatgaag gaagattctg   1080

cagaatggac ttcaaagtga gtggactgcc agctcctgat gtgtcatggt atctaaatgg   1140

aagaacagtt caatcagatg atttgcacaa aatgatagtg tctgagaagg gtcttcattc   1200

actcatcttt gaagtagtca gagcttcaga tgcaggggct tatgcatgtg ttgccaagaa   1260

tagagcagga gaagccacct tcactgtgca gctggatgtc cttgcaaaag aacataaaag   1320

agcaccaatg tttatctaca aaccacagag caaaaaagtt ttagagggag attcagtgaa   1380

actagaatgc cagatctcgg ctatacctcc accaaagctt ttctggaaaa gaaataatga   1440

aatggtacaa ttcaacactg accgaataag cttatatcaa gataacactg gaagagttac   1500

tttactgata aaagatgtaa acaagaaaga tgctgggtgg tatactgtgt cagcagttaa   1560

tgaagctgga gtgactacat gtaacacaag attagacgtt acggcacgtc caaaccaaac   1620

tcttccagct cctaagcagt tacgggttcg accaacattc agcaaatatt tagcacttaa   1680

tgggaaaggt ttgaatgtaa aacaagcttt taacccagaa ggagaatttc agcgtttggc   1740

agctcaatct ggactctatg aaagtgaaga actttaataa ctttaccaac attggaaaac   1800

agccaactac accattagta atatatttga ttacattttt ttgaaattaa tccatagctg   1860

tattaacaga ttatggtttt aattaggtaa tatagttaat atatatttat aatattattt   1920

atcctttgac tcttgcacat tctatgtacc cctccgattt gtgaagccta caggaaatct   1980

gggtatatgg atttgtaact gcagaagact atcttaaaat acaggatttt aacatttaag   2040

tcatgcacat ttaacaatta caggttataa attagtatca actttttaaa cacatctaat   2100

gcttgtaata acgtttactg gtactgcttt ctaaatactg ttttacccgt tttctcttgt   2160

aggaatacta acatggtata gattatctga gtgttccaca gttgtatgtc aaaagaaaat   2220

aaaattcaaa tatttaaaac ggac                                          2244


<210>  1131
<211>  498
<212>  PRT
<213>  Homosapiens

<400>  1131

Met Phe Asn Tyr Glu Arg Pro Lys His Phe Ile Gln Ser Gln Asn Pro 
1               5                   10                  15      


Cys Gly Ser Arg Leu Gln Pro Pro Gly Pro Glu Thr Ser Ser Phe Ser 
            20                  25                  30          


Ser Gln Thr Lys Gln Ser Ser Ile Ile Ile Gln Pro Arg Gln Cys Thr 
        35                  40                  45              


Glu Gln Arg Phe Ser Ala Ser Ser Thr Leu Ser Ser His Ile Thr Met 
    50                  55                  60                  


Ser Ser Ser Ala Phe Pro Ala Ser Pro Gln Gln His Ala Gly Ser Asn 
65                  70                  75                  80  


Pro Gly Gln Arg Val Thr Thr Thr Tyr Asn Gln Ser Pro Ala Ser Phe 
                85                  90                  95      


Leu Ser Ser Ile Leu Pro Ser Gln Pro Asp Tyr Asn Ser Ser Lys Ile 
            100                 105                 110         


Pro Ser Ala Met Asp Ser Asn Tyr Gln Gln Ser Ser Ala Gly Gln Pro 
        115                 120                 125             


Ile Asn Ala Lys Pro Ser Gln Thr Ala Asn Ala Lys Pro Ile Pro Arg 
    130                 135                 140                 


Thr Pro Asp His Glu Ile Gln Gly Ser Lys Glu Ala Leu Ile Gln Asp 
145                 150                 155                 160 


Leu Glu Arg Lys Leu Lys Cys Lys Asp Thr Leu Leu His Asn Gly Asn 
                165                 170                 175     


Gln Arg Leu Thr Tyr Glu Glu Lys Met Ala Arg Arg Leu Leu Gly Pro 
            180                 185                 190         


Gln Asn Ala Ala Ala Val Phe Gln Ala Gln Asp Asp Ser Gly Ala Gln 
        195                 200                 205             


Asp Ser Gln Gln His Asn Ser Glu His Ala Arg Leu Gln Val Pro Thr 
    210                 215                 220                 


Ser Gln Val Arg Ser Arg Ser Thr Ser Arg Gly Asp Val Asn Asp Gln 
225                 230                 235                 240 


Asp Ala Ile Gln Glu Lys Phe Tyr Pro Pro Arg Phe Ile Gln Val Pro 
                245                 250                 255     


Glu Asn Met Ser Ile Asp Glu Gly Arg Phe Cys Arg Met Asp Phe Lys 
            260                 265                 270         


Val Ser Gly Leu Pro Ala Pro Asp Val Ser Trp Tyr Leu Asn Gly Arg 
        275                 280                 285             


Thr Val Gln Ser Asp Asp Leu His Lys Met Ile Val Ser Glu Lys Gly 
    290                 295                 300                 


Leu His Ser Leu Ile Phe Glu Val Val Arg Ala Ser Asp Ala Gly Ala 
305                 310                 315                 320 


Tyr Ala Cys Val Ala Lys Asn Arg Ala Gly Glu Ala Thr Phe Thr Val 
                325                 330                 335     


Gln Leu Asp Val Leu Ala Lys Glu His Lys Arg Ala Pro Met Phe Ile 
            340                 345                 350         


Tyr Lys Pro Gln Ser Lys Lys Val Leu Glu Gly Asp Ser Val Lys Leu 
        355                 360                 365             


Glu Cys Gln Ile Ser Ala Ile Pro Pro Pro Lys Leu Phe Trp Lys Arg 
    370                 375                 380                 


Asn Asn Glu Met Val Gln Phe Asn Thr Asp Arg Ile Ser Leu Tyr Gln 
385                 390                 395                 400 


Asp Asn Thr Gly Arg Val Thr Leu Leu Ile Lys Asp Val Asn Lys Lys 
                405                 410                 415     


Asp Ala Gly Trp Tyr Thr Val Ser Ala Val Asn Glu Ala Gly Val Thr 
            420                 425                 430         


Thr Cys Asn Thr Arg Leu Asp Val Thr Ala Arg Pro Asn Gln Thr Leu 
        435                 440                 445             


Pro Ala Pro Lys Gln Leu Arg Val Arg Pro Thr Phe Ser Lys Tyr Leu 
    450                 455                 460                 


Ala Leu Asn Gly Lys Gly Leu Asn Val Lys Gln Ala Phe Asn Pro Glu 
465                 470                 475                 480 


Gly Glu Phe Gln Arg Leu Ala Ala Gln Ser Gly Leu Tyr Glu Ser Glu 
                485                 490                 495     


Glu Leu 
        


<210>  1132
<211>  2205
<212>  DNA
<213>  Homosapiens

<400>  1132
gggcggtgta gtgcaggtcc gccatggctg aggcgtcacg gtggcaccga ggcggggctt     60

cgaaacataa gttgcattac agaaaggaag tagaaattac aaccacactt caggaattgt    120

tactctactt tattttttta ataaacctat gtatattgac ttttgggatg gtaaacccac    180

atatgtatta cttaaacaag gttatgtcat ctctattttt ggacacttct gtgcctggtg    240

aagaaagaac caactttaag tccattcgca gcataactga tttttggaag tttatggaag    300

gacccctttt ggaaggtctg tactgggatt catggtacaa taaccagcag ctgtataatt    360

taaagaacag cagtcgcatc tactatgaaa atatacttct aggagttccc agagttcgtc    420

aactaaaagt ccgcaacaac acatgcaaag tctattcatc ttttcagtct ttgatgagtg    480

aatgttatgg caaatatact tctgcaaatg aagacctctc taattttggc cttcaaatta    540

atactgaatg gagatattct acttctaata ccaactcccc ttggcactgg ggatttcttg    600

gtgtttaccg aaatggggga tacattttca ctttatcaaa atcgaaatct gaaaccaaaa    660

acaagttcat tgaccttcga ctgaacagct ggatcacaag agggactaga gttattttta    720

ttgatttttc cttatataat gctaatgtaa atctattttg tattatcaga ttggtggcag    780

aattccctgc aactggagga atacttactt catggcagtt ttactctgtg aagctcctca    840

gatatgttag ctactatgac tattttattg cttcctgtga aatcacattc tgtatttttc    900

tttttgtctt cacaacacaa gaagtcaaaa aaataaaaga atttaagtct gcctatttca    960

aaagtatttg gaactggcta gaattgctac ttttgctgtt gtgttttgtg gctgtttcct   1020

tcaacacata ctataatgta caaatttttc tcttacttgg acagctgttg aaaagtactg   1080

aaaaatattc agatttctat tttcttgcat gctggcacat ttattacaat aatataattg   1140

ctattaccat cttttttgca tggataaaga tattcaaatt cataagcttt aacaagacaa   1200

tgtctcagct gtcatcaacc ttgtcccgtt gtgttaaaga catagtagga tttgccatca   1260

tgttttttat aatattcttt gcttatgccc agttaggatt tcttgttttt ggatcacaag   1320

ttgatgactt ttccactttt cagaattcca tatttgcaca atttcgaatt gttcttggag   1380

attttaattt tgctggtatt cagcaagcca atcctatctt gggacccatt tacttcatca   1440

ctttcatctt ttttgtgttc tttgtcctgc tgaatatgtt cttggcaatt attaatgata   1500

cctattctga agtgaaagct gactattcaa taggcagaag gccagatttt gaacttggca   1560

aaatgattaa acagagttac aaaaatgttc tcgagaaatt cagactgaag aaagctcaaa   1620

aagatgaaga caagaaaacc aaaggcagcg gagatttggc tgaacaagcc agaagagaag   1680

gctttgacga aaatgagatt caaaacgcag agcagatgaa aaaatggaaa gagaggcttg   1740

agaaaaagta ttattctatg gaaattcaag atgactacca gcctgtcact caagaagaat   1800

ttcgagatgg caccacaacc aagtacaaaa tgagattctc tctgagtgcc tgacaaaacg   1860

aatttaagta ccagccaagt acacacgatg atagcttcaa ggaatacaac tgactttatg   1920

atatgaattt tcaaggaacg tatcttatat ggattttgaa gaatcttgtt tgcttataag   1980

aacttcaaga agcctaagct tggctttaat tttcttgtac tctctgtact cctcaagcac   2040

tggaacacga tcctctttct gggcattcct aggggagaaa ataaaatttg taatgttcta   2100

gagatcattt ggaaaaaaag atccaaaagt tgtcttaata tgagacatac tgttactaaa   2160

cataagttca aataaaaagt tgttctgaaa aaaaaaaaaa aaaaa                   2205


<210>  1133
<211>  609
<212>  PRT
<213>  Homosapiens

<400>  1133

Met Ala Glu Ala Ser Arg Trp His Arg Gly Gly Ala Ser Lys His Lys 
1               5                   10                  15      


Leu His Tyr Arg Lys Glu Val Glu Ile Thr Thr Thr Leu Gln Glu Leu 
            20                  25                  30          


Leu Leu Tyr Phe Ile Phe Leu Ile Asn Leu Cys Ile Leu Thr Phe Gly 
        35                  40                  45              


Met Val Asn Pro His Met Tyr Tyr Leu Asn Lys Val Met Ser Ser Leu 
    50                  55                  60                  


Phe Leu Asp Thr Ser Val Pro Gly Glu Glu Arg Thr Asn Phe Lys Ser 
65                  70                  75                  80  


Ile Arg Ser Ile Thr Asp Phe Trp Lys Phe Met Glu Gly Pro Leu Leu 
                85                  90                  95      


Glu Gly Leu Tyr Trp Asp Ser Trp Tyr Asn Asn Gln Gln Leu Tyr Asn 
            100                 105                 110         


Leu Lys Asn Ser Ser Arg Ile Tyr Tyr Glu Asn Ile Leu Leu Gly Val 
        115                 120                 125             


Pro Arg Val Arg Gln Leu Lys Val Arg Asn Asn Thr Cys Lys Val Tyr 
    130                 135                 140                 


Ser Ser Phe Gln Ser Leu Met Ser Glu Cys Tyr Gly Lys Tyr Thr Ser 
145                 150                 155                 160 


Ala Asn Glu Asp Leu Ser Asn Phe Gly Leu Gln Ile Asn Thr Glu Trp 
                165                 170                 175     


Arg Tyr Ser Thr Ser Asn Thr Asn Ser Pro Trp His Trp Gly Phe Leu 
            180                 185                 190         


Gly Val Tyr Arg Asn Gly Gly Tyr Ile Phe Thr Leu Ser Lys Ser Lys 
        195                 200                 205             


Ser Glu Thr Lys Asn Lys Phe Ile Asp Leu Arg Leu Asn Ser Trp Ile 
    210                 215                 220                 


Thr Arg Gly Thr Arg Val Ile Phe Ile Asp Phe Ser Leu Tyr Asn Ala 
225                 230                 235                 240 


Asn Val Asn Leu Phe Cys Ile Ile Arg Leu Val Ala Glu Phe Pro Ala 
                245                 250                 255     


Thr Gly Gly Ile Leu Thr Ser Trp Gln Phe Tyr Ser Val Lys Leu Leu 
            260                 265                 270         


Arg Tyr Val Ser Tyr Tyr Asp Tyr Phe Ile Ala Ser Cys Glu Ile Thr 
        275                 280                 285             


Phe Cys Ile Phe Leu Phe Val Phe Thr Thr Gln Glu Val Lys Lys Ile 
    290                 295                 300                 


Lys Glu Phe Lys Ser Ala Tyr Phe Lys Ser Ile Trp Asn Trp Leu Glu 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Leu Cys Phe Val Ala Val Ser Phe Asn Thr Tyr 
                325                 330                 335     


Tyr Asn Val Gln Ile Phe Leu Leu Leu Gly Gln Leu Leu Lys Ser Thr 
            340                 345                 350         


Glu Lys Tyr Ser Asp Phe Tyr Phe Leu Ala Cys Trp His Ile Tyr Tyr 
        355                 360                 365             


Asn Asn Ile Ile Ala Ile Thr Ile Phe Phe Ala Trp Ile Lys Ile Phe 
    370                 375                 380                 


Lys Phe Ile Ser Phe Asn Lys Thr Met Ser Gln Leu Ser Ser Thr Leu 
385                 390                 395                 400 


Ser Arg Cys Val Lys Asp Ile Val Gly Phe Ala Ile Met Phe Phe Ile 
                405                 410                 415     


Ile Phe Phe Ala Tyr Ala Gln Leu Gly Phe Leu Val Phe Gly Ser Gln 
            420                 425                 430         


Val Asp Asp Phe Ser Thr Phe Gln Asn Ser Ile Phe Ala Gln Phe Arg 
        435                 440                 445             


Ile Val Leu Gly Asp Phe Asn Phe Ala Gly Ile Gln Gln Ala Asn Pro 
    450                 455                 460                 


Ile Leu Gly Pro Ile Tyr Phe Ile Thr Phe Ile Phe Phe Val Phe Phe 
465                 470                 475                 480 


Val Leu Leu Asn Met Phe Leu Ala Ile Ile Asn Asp Thr Tyr Ser Glu 
                485                 490                 495     


Val Lys Ala Asp Tyr Ser Ile Gly Arg Arg Pro Asp Phe Glu Leu Gly 
            500                 505                 510         


Lys Met Ile Lys Gln Ser Tyr Lys Asn Val Leu Glu Lys Phe Arg Leu 
        515                 520                 525             


Lys Lys Ala Gln Lys Asp Glu Asp Lys Lys Thr Lys Gly Ser Gly Asp 
    530                 535                 540                 


Leu Ala Glu Gln Ala Arg Arg Glu Gly Phe Asp Glu Asn Glu Ile Gln 
545                 550                 555                 560 


Asn Ala Glu Gln Met Lys Lys Trp Lys Glu Arg Leu Glu Lys Lys Tyr 
                565                 570                 575     


Tyr Ser Met Glu Ile Gln Asp Asp Tyr Gln Pro Val Thr Gln Glu Glu 
            580                 585                 590         


Phe Arg Asp Gly Thr Thr Thr Lys Tyr Lys Met Arg Phe Ser Leu Ser 
        595                 600                 605             


Ala 
    


<210>  1134
<211>  5470
<212>  DNA
<213>  Homosapiens

<400>  1134
ccgcctctgt cgccactctc tccccctgtt ccgcgtctgc gtcgccacca ccgccggggg     60

tatccggggg gtcgcttacc gggctggccc cgcgccacag ccgtagcttt aacctccccg    120

tcagcggccg ccccaggaag aggcttctcg gccgcggagc cacttggggc ctcagttctc    180

gccctcttgc cgtcgccgcg ggtcctggag aagcggccgc ggccagggaa cggggcatcg    240

cggttccaac gattaactgc tgaagtactg atcgagttct gcatttcttc aatgaggaac    300

tacaggctga tcttctgcca taatctcaaa cagccataaa tgacaaaaga atgcttgctc    360

agtgagggta gctggtgcag aagccatttt ttaaacttag gtatttaagt actgaaagaa    420

aagacagctt tgatttctgg ctgcaaaaaa gatatgagga agagctcctc cccttccttg    480

agtaactgca actccgttct tgctaacaaa atatttggaa ttccacttga tgagctgcag    540

cagggaggac atccagacat tgaggttcca ttcatagtcc gccacgttgt ggactatatt    600

gaggaacatg gaggtctgga gcaacaagga ctttttcaag tcaatggaaa tgctgagaca    660

gtggagtggc ttcggcagag atacgacagc ggagaagagg tggatttggt taaggaagca    720

gatgttccct cagctattag ccttcttaga ttttttcttc aagaacttcc tgaacctgtt    780

atccctggca gtttacatat tcacttgatg cagctttctc aagattataa taatgaagat    840

gaatttggaa gaaagttgag gttcctcttg caacagcttc cacctgttaa ttatagtttg    900

ttaaagtttc tgtgtagatt tttagccaat gtagcatcac atcatgaaga aatttggtct    960

gcaaattctt tggctgctgt ctttggtcca gatgtcttcc acatttacac agatgtggaa   1020

gacatgaaag agcaagaaat agtgagcagg ataatggctg gacttctgga aaactactat   1080

gagttttttg agaatgaaga ggaagatttt tcatctaatg atttgagttc aattactgaa   1140

caggttaatg aactttctga ggaagaagag gaagatgaaa agctggaaca tattgaagaa   1200

cttccagaag agggtgcaga aaaatcaaat gacatgccag aggtggtaca attaaggatg   1260

actgaaaaca tcctggaatc aaatagtgtt acggcaacaa gcacccatat atctcccatc   1320

agcatcctac cagcctctac agatatttta gaaagaacaa ttagagcagc tgtggaacag   1380

cacctttttg atcttcagag cagcatagat catgatctta agaatttaca acagcaaagt   1440

gtggtgtgta ataatgaagc agaaagtatt cattgtgatg gggaaggatc taataaccag   1500

attgatattg ctgatgatat tattaatgcc agtgaaagta acagagactg ttcaaaacct   1560

gtggctagca ctaatttaga caatgaagct atgcagcaag attgtgtatt tgagaatgaa   1620

gaaaataccc agtctgtagg tatattgtta gagccatgca gtgaccgtgg tgatagtgaa   1680

gatggctgtc ttgagaggga agaatatttg ttatttgaca gtgataaatt gtcacacttg   1740

attctggatt ctagtagcaa gatatgtgat ttgaatgcca acactgaatc agaagtacca   1800

ggaggtcaga gtgttggtgt tcaaggggaa gcagcgtgtg tcagtattcc acatttagat   1860

ctgaagaatg tttctgatgg tgataaatgg gaagagccat ttcctgcttt taagtcttgg   1920

caggaggact ctgagtctgg agaagctcag ctgtctccac aagctggaag aatgaatcat   1980

caccccttgg aagaggactg tcctccagta ttatcacacc gcagtttaga ttttggtcaa   2040

agccagcgtt tcctacatga tccagaaaag ttggattcct catctaaagc actgtctttt   2100

actagaattc gaagatcatc ctttagttca aaagatgaaa agagagagga cagaacacct   2160

tatcagctgg tcaagaaact tcagaagaaa atcagacaat ttgaggaaca gtttgaaagg   2220

gaaagaaata gcaagccctc ctacagtgat attgctgcca atccaaaggt attaaaatgg   2280

atgacagagc ttacaaaact gcggaagcaa attaaagatg caaaacacaa aaattctgat   2340

ggagaatttg tacctcagac acgtccacgt agtaacacac ttccaaaaag ctttggctct   2400

tctctagacc atgaagatga agagaatgaa gatgaaccca aggtcattca gaaggagaaa   2460

aaaccatcta aagaagcaac ccttgaactt attcttaaaa gactgaaaga aaaacgtatt   2520

gagaggtgtc ttccagaaga tatcaagaaa atgaccaaag atcatttggt agaagagaaa   2580

gcttctcttc agaaaagtct tctttactat gaaagtcaac atggaaggcc ggtgaccaag   2640

gaagaaaggc acattgttaa acctctctat gatagataca ggcttgtaaa acaaatgctg   2700

acaagagcta gcatcactcc tgtccttgga tctccatcca ccaagcgaag gggtcagatg   2760

ttacagccaa tcatagaagg agaaactgca catttttttg aagaaatcaa ggaggaagaa   2820

gaagatggtg ttaatctgtc ctctgagtta ggtgatatgt tgaaaactgc agtacaggta   2880

cagtcttcat tagaaaactc tgaatctgat gttgaagaaa atcaagaaaa actggctctg   2940

gatctccgat tgtcaagttc tcgagcagct tctatgcctg aattattgga acaactttgg   3000

aaagccagag ctgaaaaaaa gaaactacgc aaaacgttgc gggaatttga agaagcattt   3060

tatcaacaaa atggaaggaa tgcccagaaa gaggatcgtg ttccagtgct tgaggagtac   3120

agagagtaca agaaaattaa agccaagctt aggcttcttg aagttcttat aagcaaacaa   3180

gattcttcaa aatccatata agatacgttc cttgaaaatt catatcataa agtcagttgt   3240

attccttgaa gctatcatcg tgtgtacttg gctggtactt aaattcgttt tgtcaggcac   3300

tcagagaatc tcattttgta cttggttgtg gtgccactaa acaaaacaaa tgatgggaga   3360

gtaagtaggc cctctcaagg gagcgtaagt gatgttccat attaaccaca gactgtcctc   3420

tccaccttta gcaaacatat ggtttacttc attgttttgt actacagata catcctttta   3480

gcaaaagact ggaattttat cctttcaact tcaagaactt tggaaatgca agctttttgt   3540

tattaccaac tttttgtttc tcattactga agaaaattgg aggaaaatct tcatactgaa   3600

ttcttctgtt gcctttttct tacagaatga ctgaaaattt gaaagaaaag cctataaaag   3660

tgcacatacg caactgtgtt ctctgttttc ctagaaaacc aaaatcaaac tgagatttca   3720

agtcgtacta tggaacacct ttctgtttaa ttcccaaagt gacatcttct cacaggtagt   3780

atgttagtaa aattttgcaa ttcgctggtc acacagctcc cggatgaaga taacagttgg   3840

tagaccaaaa ggtgacctcg cttagtatat tgaaaacaca caccacacat cacacacaga   3900

actgaatcat accacatgct gcctatggga cttcagttac tgtttcctga gttactgttt   3960

atccgctggc aatggtgtga tttgtctgga tcagatccgc gctattcccc aacccacctc   4020

cagataatgt gagaaaatag ccatgtcagt atgtaggaac tctgatggtg ctcagatttg   4080

tgtgttcaat caatgggctt aaatcagcaa aatattatgc ctaaagtaaa tctgttctta   4140

acaagggctc taccactgca ttttcacatg taccttcagg gggttatctt tttttttttc   4200

ccctcctatt ttaatcagca aaatccatac caaaacaacg acaacaacgc cctcttaagg   4260

gaccaccctt tggtcaatca taacatgctg tttaaagcag ctgtttacag gatgtgtagt   4320

ggtatgcccc ttgtcatata ctcttagcat atcttttttt cctttggctt tgcatggctt   4380

ttcttcaggt actgtctcgg tatcattctg ctaatcattg ttacagaatg gtgacttcat   4440

ttgtgctaac agtacaacag cagatttggg tcaggcttaa tctaagtgtt aacttttttt   4500

tctggtgctt ttttggattg atgactgtct cactttgact atacccatgt tttgcatgca   4560

atgactcatg catggttttc ttaactagct aatattaaca atttattcca tataaaaatg   4620

gaattttgca acatccttta ataaggtgag ggaagcatga acctcagact tctggcacta   4680

ttacatagta agcacatgaa gtagtttgat aataaatagc agttctagta cttcacattt   4740

cacccgtgtg tgcaatgcct ttttctgggg ggtggggggt gagggaaaac ctggtagtga   4800

atgtgtagtt ggggaataaa gaaaagcact aaatcctgcc ctttttgtgt ggtttccttt   4860

tgatacaact aggttattca taatgtatac ctagaaaagt gaaattgaaa ataccaaaag   4920

atgtatcatt tttatttgaa tccatcatgc agtgtacatt tcagataatt tccttcagtc   4980

tccagatagg agtgtatcca aacatctaat tttatgtgca ctgtgtatct tatatgaatg   5040

ttttattttt tataccacat gcaaaaatgt ccatatgcac tatttaaatg ttttaaataa   5100

tatattcctt ctttataatg ctaaatctat atgagtacca tatttttata agtcagtggt   5160

ctgactggtt tcattttaga attaacagct gcttcaatat gttattcaat gttaatgttt   5220

ggctgtgagt agaatatgta aaagtggcat ggcagcactt atgctctgtg acagtattgt   5280

gtgtcatagt tgagcagtag ctggtagaat taggcagttg gtgatagttt tactttggta   5340

caaataaaaa ctgtatatct atatacaaat aatatataga tatatatgtc caccagtata   5400

atggcattgc tgtgtctggc acttcattgt acagactttt ataataaaag aacttgaaag   5460

ttctaaaaaa                                                          5470


<210>  1135
<211>  915
<212>  PRT
<213>  Homosapiens

<400>  1135

Met Arg Lys Ser Ser Ser Pro Ser Leu Ser Asn Cys Asn Ser Val Leu 
1               5                   10                  15      


Ala Asn Lys Ile Phe Gly Ile Pro Leu Asp Glu Leu Gln Gln Gly Gly 
            20                  25                  30          


His Pro Asp Ile Glu Val Pro Phe Ile Val Arg His Val Val Asp Tyr 
        35                  40                  45              


Ile Glu Glu His Gly Gly Leu Glu Gln Gln Gly Leu Phe Gln Val Asn 
    50                  55                  60                  


Gly Asn Ala Glu Thr Val Glu Trp Leu Arg Gln Arg Tyr Asp Ser Gly 
65                  70                  75                  80  


Glu Glu Val Asp Leu Val Lys Glu Ala Asp Val Pro Ser Ala Ile Ser 
                85                  90                  95      


Leu Leu Arg Phe Phe Leu Gln Glu Leu Pro Glu Pro Val Ile Pro Gly 
            100                 105                 110         


Ser Leu His Ile His Leu Met Gln Leu Ser Gln Asp Tyr Asn Asn Glu 
        115                 120                 125             


Asp Glu Phe Gly Arg Lys Leu Arg Phe Leu Leu Gln Gln Leu Pro Pro 
    130                 135                 140                 


Val Asn Tyr Ser Leu Leu Lys Phe Leu Cys Arg Phe Leu Ala Asn Val 
145                 150                 155                 160 


Ala Ser His His Glu Glu Ile Trp Ser Ala Asn Ser Leu Ala Ala Val 
                165                 170                 175     


Phe Gly Pro Asp Val Phe His Ile Tyr Thr Asp Val Glu Asp Met Lys 
            180                 185                 190         


Glu Gln Glu Ile Val Ser Arg Ile Met Ala Gly Leu Leu Glu Asn Tyr 
        195                 200                 205             


Tyr Glu Phe Phe Glu Asn Glu Glu Glu Asp Phe Ser Ser Asn Asp Leu 
    210                 215                 220                 


Ser Ser Ile Thr Glu Gln Val Asn Glu Leu Ser Glu Glu Glu Glu Glu 
225                 230                 235                 240 


Asp Glu Lys Leu Glu His Ile Glu Glu Leu Pro Glu Glu Gly Ala Glu 
                245                 250                 255     


Lys Ser Asn Asp Met Pro Glu Val Val Gln Leu Arg Met Thr Glu Asn 
            260                 265                 270         


Ile Leu Glu Ser Asn Ser Val Thr Ala Thr Ser Thr His Ile Ser Pro 
        275                 280                 285             


Ile Ser Ile Leu Pro Ala Ser Thr Asp Ile Leu Glu Arg Thr Ile Arg 
    290                 295                 300                 


Ala Ala Val Glu Gln His Leu Phe Asp Leu Gln Ser Ser Ile Asp His 
305                 310                 315                 320 


Asp Leu Lys Asn Leu Gln Gln Gln Ser Val Val Cys Asn Asn Glu Ala 
                325                 330                 335     


Glu Ser Ile His Cys Asp Gly Glu Gly Ser Asn Asn Gln Ile Asp Ile 
            340                 345                 350         


Ala Asp Asp Ile Ile Asn Ala Ser Glu Ser Asn Arg Asp Cys Ser Lys 
        355                 360                 365             


Pro Val Ala Ser Thr Asn Leu Asp Asn Glu Ala Met Gln Gln Asp Cys 
    370                 375                 380                 


Val Phe Glu Asn Glu Glu Asn Thr Gln Ser Val Gly Ile Leu Leu Glu 
385                 390                 395                 400 


Pro Cys Ser Asp Arg Gly Asp Ser Glu Asp Gly Cys Leu Glu Arg Glu 
                405                 410                 415     


Glu Tyr Leu Leu Phe Asp Ser Asp Lys Leu Ser His Leu Ile Leu Asp 
            420                 425                 430         


Ser Ser Ser Lys Ile Cys Asp Leu Asn Ala Asn Thr Glu Ser Glu Val 
        435                 440                 445             


Pro Gly Gly Gln Ser Val Gly Val Gln Gly Glu Ala Ala Cys Val Ser 
    450                 455                 460                 


Ile Pro His Leu Asp Leu Lys Asn Val Ser Asp Gly Asp Lys Trp Glu 
465                 470                 475                 480 


Glu Pro Phe Pro Ala Phe Lys Ser Trp Gln Glu Asp Ser Glu Ser Gly 
                485                 490                 495     


Glu Ala Gln Leu Ser Pro Gln Ala Gly Arg Met Asn His His Pro Leu 
            500                 505                 510         


Glu Glu Asp Cys Pro Pro Val Leu Ser His Arg Ser Leu Asp Phe Gly 
        515                 520                 525             


Gln Ser Gln Arg Phe Leu His Asp Pro Glu Lys Leu Asp Ser Ser Ser 
    530                 535                 540                 


Lys Ala Leu Ser Phe Thr Arg Ile Arg Arg Ser Ser Phe Ser Ser Lys 
545                 550                 555                 560 


Asp Glu Lys Arg Glu Asp Arg Thr Pro Tyr Gln Leu Val Lys Lys Leu 
                565                 570                 575     


Gln Lys Lys Ile Arg Gln Phe Glu Glu Gln Phe Glu Arg Glu Arg Asn 
            580                 585                 590         


Ser Lys Pro Ser Tyr Ser Asp Ile Ala Ala Asn Pro Lys Val Leu Lys 
        595                 600                 605             


Trp Met Thr Glu Leu Thr Lys Leu Arg Lys Gln Ile Lys Asp Ala Lys 
    610                 615                 620                 


His Lys Asn Ser Asp Gly Glu Phe Val Pro Gln Thr Arg Pro Arg Ser 
625                 630                 635                 640 


Asn Thr Leu Pro Lys Ser Phe Gly Ser Ser Leu Asp His Glu Asp Glu 
                645                 650                 655     


Glu Asn Glu Asp Glu Pro Lys Val Ile Gln Lys Glu Lys Lys Pro Ser 
            660                 665                 670         


Lys Glu Ala Thr Leu Glu Leu Ile Leu Lys Arg Leu Lys Glu Lys Arg 
        675                 680                 685             


Ile Glu Arg Cys Leu Pro Glu Asp Ile Lys Lys Met Thr Lys Asp His 
    690                 695                 700                 


Leu Val Glu Glu Lys Ala Ser Leu Gln Lys Ser Leu Leu Tyr Tyr Glu 
705                 710                 715                 720 


Ser Gln His Gly Arg Pro Val Thr Lys Glu Glu Arg His Ile Val Lys 
                725                 730                 735     


Pro Leu Tyr Asp Arg Tyr Arg Leu Val Lys Gln Met Leu Thr Arg Ala 
            740                 745                 750         


Ser Ile Thr Pro Val Leu Gly Ser Pro Ser Thr Lys Arg Arg Gly Gln 
        755                 760                 765             


Met Leu Gln Pro Ile Ile Glu Gly Glu Thr Ala His Phe Phe Glu Glu 
    770                 775                 780                 


Ile Lys Glu Glu Glu Glu Asp Gly Val Asn Leu Ser Ser Glu Leu Gly 
785                 790                 795                 800 


Asp Met Leu Lys Thr Ala Val Gln Val Gln Ser Ser Leu Glu Asn Ser 
                805                 810                 815     


Glu Ser Asp Val Glu Glu Asn Gln Glu Lys Leu Ala Leu Asp Leu Arg 
            820                 825                 830         


Leu Ser Ser Ser Arg Ala Ala Ser Met Pro Glu Leu Leu Glu Gln Leu 
        835                 840                 845             


Trp Lys Ala Arg Ala Glu Lys Lys Lys Leu Arg Lys Thr Leu Arg Glu 
    850                 855                 860                 


Phe Glu Glu Ala Phe Tyr Gln Gln Asn Gly Arg Asn Ala Gln Lys Glu 
865                 870                 875                 880 


Asp Arg Val Pro Val Leu Glu Glu Tyr Arg Glu Tyr Lys Lys Ile Lys 
                885                 890                 895     


Ala Lys Leu Arg Leu Leu Glu Val Leu Ile Ser Lys Gln Asp Ser Ser 
            900                 905                 910         


Lys Ser Ile 
        915 


<210>  1136
<211>  1498
<212>  DNA
<213>  Homosapiens

<400>  1136
gggcgatggg gaacctgttt atgctctggg cagctctggg catatgctgt gctgcattca     60

gtgcctctgc ctggtcagtg aacaatttcc tgataacagg tcccaaggcc tatctgacct    120

acacgactag tgtggccttg ggtgcccaga gtggcatcga ggagtgcaag ttccagtttg    180

cttgggaacg ctggaactgc cctgaaaatg ctcttcagct ctccacccac aacaggctga    240

gaagtgctac cagagagact tccttcatac atgctatcag ctctgctgga gtcatgtaca    300

tcatcaccaa gaactgtagc atgggtgact tcgaaaactg tggctgtgat gggtcaaaca    360

atggaaaaac aggaggccat ggctggatct ggggaggctg cagcgacaat gtggaatttg    420

gggaaaggat ctccaaactc tttgtggaca gtttggagaa ggggaaggat gccagagccc    480

tgatgaatct tcacaacaac agggccggca gactggcagt gagagccacc atgaaaagga    540

catgcaaatg tcatggcatc tctgggagct gcagcataca gacatgctgg ctgcagctgg    600

ctgaattccg ggagatggga gactacctaa aggccaagta tgaccaggcg ctgaaaattg    660

aaatggataa gcggcagctg agagctggga acagcgccga gggccactgg gtgcccgctg    720

aggccttcct tcctagcgca gaggcggaac tgatcttttt agaggaatca ccagattact    780

gtacctgcaa ttccagcctg ggcatctatg gcacagaggg tcgtgagtgc ctacagaaca    840

gccacaacac atccaggtgg gagcgacgta gctgtgggcg cctgtgcact gagtgtgggc    900

tgcaggtgga agagaggaaa actgaggtca taagcagctg taactgcaaa ttccagtggt    960

gctgtacggt caagtgtgac cagtgtaggc atgtggtgag caagtattac tgcgcacgct   1020

ccccaggcag tgcccagtcc ctgggtaagg gcagtgcctg ataatacccc acacaagttc   1080

acttgattaa ttgcatcagt ggaaggggac atagcttctc tcttagagag aacagattgg   1140

aaagcaatcg gaaaattgca gttttggtct gtagtcctca tgatatctgc tatcagtggg   1200

gaaaatggag gcccaagatt ctacagcata ttcctggcgg ggctgaaatt ggaacctggg   1260

cctcctgact ttggcagacc cccatttcat ctttcctgca aactactttc ccatctttgt   1320

gcctgtactt atgcagcttt ctacagggag agtttggttt ggggtctata tctagaggga   1380

ccttcaaagt atttgttcct ttaaatttca gaccatgtcc aacccagctg tgctgctggg   1440

aatcaggaga atagaagcaa aaaacgaaag agttctgttc agacttctga agagcagc     1498


<210>  1137
<211>  351
<212>  PRT
<213>  Homosapiens

<400>  1137

Met Gly Asn Leu Phe Met Leu Trp Ala Ala Leu Gly Ile Cys Cys Ala 
1               5                   10                  15      


Ala Phe Ser Ala Ser Ala Trp Ser Val Asn Asn Phe Leu Ile Thr Gly 
            20                  25                  30          


Pro Lys Ala Tyr Leu Thr Tyr Thr Thr Ser Val Ala Leu Gly Ala Gln 
        35                  40                  45              


Ser Gly Ile Glu Glu Cys Lys Phe Gln Phe Ala Trp Glu Arg Trp Asn 
    50                  55                  60                  


Cys Pro Glu Asn Ala Leu Gln Leu Ser Thr His Asn Arg Leu Arg Ser 
65                  70                  75                  80  


Ala Thr Arg Glu Thr Ser Phe Ile His Ala Ile Ser Ser Ala Gly Val 
                85                  90                  95      


Met Tyr Ile Ile Thr Lys Asn Cys Ser Met Gly Asp Phe Glu Asn Cys 
            100                 105                 110         


Gly Cys Asp Gly Ser Asn Asn Gly Lys Thr Gly Gly His Gly Trp Ile 
        115                 120                 125             


Trp Gly Gly Cys Ser Asp Asn Val Glu Phe Gly Glu Arg Ile Ser Lys 
    130                 135                 140                 


Leu Phe Val Asp Ser Leu Glu Lys Gly Lys Asp Ala Arg Ala Leu Met 
145                 150                 155                 160 


Asn Leu His Asn Asn Arg Ala Gly Arg Leu Ala Val Arg Ala Thr Met 
                165                 170                 175     


Lys Arg Thr Cys Lys Cys His Gly Ile Ser Gly Ser Cys Ser Ile Gln 
            180                 185                 190         


Thr Cys Trp Leu Gln Leu Ala Glu Phe Arg Glu Met Gly Asp Tyr Leu 
        195                 200                 205             


Lys Ala Lys Tyr Asp Gln Ala Leu Lys Ile Glu Met Asp Lys Arg Gln 
    210                 215                 220                 


Leu Arg Ala Gly Asn Ser Ala Glu Gly His Trp Val Pro Ala Glu Ala 
225                 230                 235                 240 


Phe Leu Pro Ser Ala Glu Ala Glu Leu Ile Phe Leu Glu Glu Ser Pro 
                245                 250                 255     


Asp Tyr Cys Thr Cys Asn Ser Ser Leu Gly Ile Tyr Gly Thr Glu Gly 
            260                 265                 270         


Arg Glu Cys Leu Gln Asn Ser His Asn Thr Ser Arg Trp Glu Arg Arg 
        275                 280                 285             


Ser Cys Gly Arg Leu Cys Thr Glu Cys Gly Leu Gln Val Glu Glu Arg 
    290                 295                 300                 


Lys Thr Glu Val Ile Ser Ser Cys Asn Cys Lys Phe Gln Trp Cys Cys 
305                 310                 315                 320 


Thr Val Lys Cys Asp Gln Cys Arg His Val Val Ser Lys Tyr Tyr Cys 
                325                 330                 335     


Ala Arg Ser Pro Gly Ser Ala Gln Ser Leu Gly Lys Gly Ser Ala 
            340                 345                 350     


<210>  1138
<211>  1243
<212>  DNA
<213>  Homosapiens

<400>  1138
gcagccaccg tccccacgct ggggcttcag gtctcctagc aacaagttgt accatatgag     60

gacggccgct gagccataat ggagatatca atgcctccac ctcagatata tgtagaaaaa    120

actctggcca ttatcaaacc agatattgtt gacaaagagg aggagataca agatattatt    180

cttagatccg gattcaccat tgttcagaga agaaaactac gcctcagccc tgagcaatgt    240

agtaactttt atgtggaaaa gtatggaaaa atgtttttcc ccaacttaac agcttacatg    300

agttctggac cacttgtcgc catgatatta gctagacata aagccatctc ttattggtta    360

gaacttttgg gaccaaataa tagcttagta gcgaaggaga cacatccaga cagtctgagg    420

gcaatttatg gcacagatga cctaaggaat gcacttcatg ggagtaatga ctttgctgct    480

gcggaaagag aaatacgttt tatgtttcct gaagtgattg ttgagcccat tccaattgga    540

caagctgcta aggactattt aaatttacat ataatgccaa ctctgcttga aggactcaca    600

gagctttgta agcaaaaacc agcagatcct ttgatttggc tagctgattg gctgctgaaa    660

aataatccta acaaacccaa actttgtcac catccaattg tagaagaacc ttattaaaaa    720

aaaaatcctc gaaagaacaa atcatgaact atcttattat aaaaggctgt acttctactg    780

tttgaaaaaa ttatttctag ggtttaagta actacaagta aaataaattt atttcttaaa    840

aataagtgtt aaaggaataa ctattctatg aagcagataa cattaaggta aaatataggc    900

ttagagtatg attttaacaa tgatgtaaca ctaggtaatg gaaaactcat gtaagatgtt    960

gctagatgtt tttgtttttc ttaagtttga gaagtaagac ataaagttta gttatacatt   1020

ttcccaagca catatcctat atctaaatac ataattaatg cacagttgag acagtctagt   1080

ttaaaaggct taggtccttt tgtagtccat aagcatggtg atttggtttc atgctcatgt   1140

gtcagatatg cttccctcaa accttgttac agcatcatca cattacctgt ttgatgtaaa   1200

aaataaaaaa tagaaaggtg taagtaaaaa aaaaaaaaaa aaa                     1243


<210>  1139
<211>  212
<212>  PRT
<213>  Homosapiens

<400>  1139

Met Glu Ile Ser Met Pro Pro Pro Gln Ile Tyr Val Glu Lys Thr Leu 
1               5                   10                  15      


Ala Ile Ile Lys Pro Asp Ile Val Asp Lys Glu Glu Glu Ile Gln Asp 
            20                  25                  30          


Ile Ile Leu Arg Ser Gly Phe Thr Ile Val Gln Arg Arg Lys Leu Arg 
        35                  40                  45              


Leu Ser Pro Glu Gln Cys Ser Asn Phe Tyr Val Glu Lys Tyr Gly Lys 
    50                  55                  60                  


Met Phe Phe Pro Asn Leu Thr Ala Tyr Met Ser Ser Gly Pro Leu Val 
65                  70                  75                  80  


Ala Met Ile Leu Ala Arg His Lys Ala Ile Ser Tyr Trp Leu Glu Leu 
                85                  90                  95      


Leu Gly Pro Asn Asn Ser Leu Val Ala Lys Glu Thr His Pro Asp Ser 
            100                 105                 110         


Leu Arg Ala Ile Tyr Gly Thr Asp Asp Leu Arg Asn Ala Leu His Gly 
        115                 120                 125             


Ser Asn Asp Phe Ala Ala Ala Glu Arg Glu Ile Arg Phe Met Phe Pro 
    130                 135                 140                 


Glu Val Ile Val Glu Pro Ile Pro Ile Gly Gln Ala Ala Lys Asp Tyr 
145                 150                 155                 160 


Leu Asn Leu His Ile Met Pro Thr Leu Leu Glu Gly Leu Thr Glu Leu 
                165                 170                 175     


Cys Lys Gln Lys Pro Ala Asp Pro Leu Ile Trp Leu Ala Asp Trp Leu 
            180                 185                 190         


Leu Lys Asn Asn Pro Asn Lys Pro Lys Leu Cys His His Pro Ile Val 
        195                 200                 205             


Glu Glu Pro Tyr 
    210         


<210>  1140
<211>  3253
<212>  DNA
<213>  Homosapiens

<400>  1140
gggtttcggc ccttccagac cgtctctcct cagggttgga gacttcgggg ccaagatggc     60

gacgggaacg ggcaaacaca agctgctaag cactggcccc acagagccat ggtccatccg    120

agagaagcta tgtttagcat cttctgtcat gagaagtggc gatcaaaatt gggtatcagt    180

tagcagagca atcaagccct ttgcagaacc tggccgccct ccagactggt tctctcaaaa    240

acattgtgct tcccagtact cggagctttt agagaccact gagacaccaa aacggaaacg    300

aggtgaaaag ggagaagtgg tggaaactgt tgaagatgtt attgttcgga aattgactgc    360

tgagcgagtt gaagaactaa agaaagtgat aaaggaaacc caggagagat atagacggct    420

aaagagagat gcagaactaa ttcaagctgg acacatggac agcagactgg atgagctttg    480

caatgacatt gcaacgaaaa agaaattgga agaagaggag gctgaagtaa agaggaaggc    540

tacagatgct gcataccagg ctcgtcaagc agtaaaaaca cccccccgga ggttacccac    600

tgtgatggtt cgctctccta tagattctgc ctccccagga ggtgattatc cacttgggga    660

cttgactcca accactatgg aagaggctac ctctggggta acccccggga ctttgccgag    720

taccccagtc acctcgtttc ctgggattcc tgacaccctt cctccaggct ctgcaccctt    780

agaagccccc atgaccccag taacagatga ttcaccccag aaaaagatgc ttggacagaa    840

agcaactcca cccccctccc ctctgctgtc agagctcttg aagaagggca gcctcctgcc    900

tactagcccc agactggtca atgagagtga aatggctgtg gcttctggcc acctgaacag    960

tacaggtgtc ctcctggagg taggcggggt ccttcccatg atacatggtg gggagataca   1020

gcaaacaccc aatactgttg cagcctcccc tgctgcatca ggtgctccca ctctttcccg   1080

gcttttagaa gctggtccta cacagttcac cacacctctt gcttccttca ctactgttgc   1140

cagtgagcct ccagttaaac ttgtgccacc ccctgtagag tctgtgtccc aagctaccat   1200

tgtcatgatg cctgcgctgc cagcaccatc ctctgctccg gctgtctcca ctactgaaag   1260

tgtagctcca gtgagtcaac ccgacaactg tgttcccatg gaggctgtgg gggatccaca   1320

tactgtgact gtttccatgg acagcagtga aatatccatg atcatcaatt ctatcaaaga   1380

agagtgtttt cgatcagggg tagcagaggc tcctgttgga tcaaaggctc ccagcataga   1440

tgggaaggaa gaattagatc tggctgagaa gatggatatt gctgtgtctt acacaggtga   1500

agagctggat tttgagactg ttggagacat cattgccatc attgaggaca aggtagatga   1560

tcatcctgaa gtgctggatg tggcagcagt ggaagcagca ctgtcatttt gtgaagaaaa   1620

tgatgatcct cagtccctgc ctggcccctg ggagcatcct atccagcagg agcgggacaa   1680

gccagtacct ctccctgcac cagaaatgac ggtcaagcaa gagagactgg actttgagga   1740

aacggaaaac aagggaatac atgaactggt ggacatcagg gagcccagtg cagagatcaa   1800

ggtggaacct gcagaaccag agccagtcat ttcaggagcc gaaatagtag ctggagttgt   1860

tccagccaca agtatggagc caccagaact caggagtcag gacttagatg aggaactggg   1920

aagtactgca gctggagaga ttgttgaagc agatgttgcc attgggaaag gcgatgagac   1980

tccacttaca aatgtgaaga cagaggcatc ccctgaaagc atgttgtctc catcacatgg   2040

ctcaaatccc attgaagatc ctttagaggc agagactcag cacaagtttg aaatgtcaga   2100

ctcattgaaa gaagaatcag ggactatttt tggaagccag ataaaggatg ccccaggtga   2160

ggatgaggag gaagatggtg tcagtgaagc ggccagccta gaggagccta aggaagagga   2220

tcaaggagaa ggctacttgt cagaaatgga taatgaacct cctgtgagcg agagtgatga   2280

tggcttcagc atacacaatg ctacactgca gtcacacaca ctggcagact ccatccccag   2340

cagccctgct tcttcacagt tctctgtctg tagtgaggat caggaagcta ttcaggcaca   2400

gaaaatttgg aagaaagcca tcatgcttgt atggagagct gcagctaatc ataggtatgc   2460

caatgtcttc ctgcagcctg ttacagatga catagcacct ggctaccaca gcattgtgca   2520

gaggcctatg gatttgtcaa ctattaagaa aaacatagaa aatggactga tccgaagcac   2580

agctgaattt cagcgtgaca ttatgctgat gtttcagaat gctgtaatgt acaatagctc   2640

agaccatgat gtctatcaca tggcagtgga gatgcagcga gatgtcttgg aacagatcca   2700

gcaattcttg gccacgcagt tgattatgca aacatccgag tctgggatca gtgctaaaag   2760

tcttcgaggg agagattcta cccgcaaaca ggatgcttca gagaaggaca gtgtcccaat   2820

gggctctcct gccttccttc tctctctctt tgatggagga accaggggac gccgctgtgc   2880

cattgaagca gatatgaaga tgaaaaagtg aagcctcaga gttaccctct ttgagccgaa   2940

cctaaaataa aagtaaacaa gatagagctt gggcttgcgg gcccagttcc agaggtggaa   3000

gttacagaag aggaggtacc tgggccacac gacatgagct ggaaaatctc tcttagagag   3060

ttggagtagc acaattgcct gttttagggc agaaaccatg ggctatgtta atgtcctaat   3120

gtgtagctag cagatcgtag ctagtttgta ttgtcttgtc aattgtacag actttttaaa   3180

aaaaacaacc accagtgaaa tgtgtgtgta tacaataaac tgaaaaaaaa aactaaaaaa   3240

aaaaaaaaaa aaa                                                      3253


<210>  1141
<211>  951
<212>  PRT
<213>  Homosapiens

<400>  1141

Met Ala Thr Gly Thr Gly Lys His Lys Leu Leu Ser Thr Gly Pro Thr 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro 
        35                  40                  45              


Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys 
    50                  55                  60                  


Ala Ser Gln Tyr Ser Glu Leu Leu Glu Thr Thr Glu Thr Pro Lys Arg 
65                  70                  75                  80  


Lys Arg Gly Glu Lys Gly Glu Val Val Glu Thr Val Glu Asp Val Ile 
                85                  90                  95      


Val Arg Lys Leu Thr Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile 
            100                 105                 110         


Lys Glu Thr Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu 
        115                 120                 125             


Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp 
    130                 135                 140                 


Ile Ala Thr Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg 
145                 150                 155                 160 


Lys Ala Thr Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Thr Pro 
                165                 170                 175     


Pro Arg Arg Leu Pro Thr Val Met Val Arg Ser Pro Ile Asp Ser Ala 
            180                 185                 190         


Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Thr Pro Thr Thr Met 
        195                 200                 205             


Glu Glu Ala Thr Ser Gly Val Thr Pro Gly Thr Leu Pro Ser Thr Pro 
    210                 215                 220                 


Val Thr Ser Phe Pro Gly Ile Pro Asp Thr Leu Pro Pro Gly Ser Ala 
225                 230                 235                 240 


Pro Leu Glu Ala Pro Met Thr Pro Val Thr Asp Asp Ser Pro Gln Lys 
                245                 250                 255     


Lys Met Leu Gly Gln Lys Ala Thr Pro Pro Pro Ser Pro Leu Leu Ser 
            260                 265                 270         


Glu Leu Leu Lys Lys Gly Ser Leu Leu Pro Thr Ser Pro Arg Leu Val 
        275                 280                 285             


Asn Glu Ser Glu Met Ala Val Ala Ser Gly His Leu Asn Ser Thr Gly 
    290                 295                 300                 


Val Leu Leu Glu Val Gly Gly Val Leu Pro Met Ile His Gly Gly Glu 
305                 310                 315                 320 


Ile Gln Gln Thr Pro Asn Thr Val Ala Ala Ser Pro Ala Ala Ser Gly 
                325                 330                 335     


Ala Pro Thr Leu Ser Arg Leu Leu Glu Ala Gly Pro Thr Gln Phe Thr 
            340                 345                 350         


Thr Pro Leu Ala Ser Phe Thr Thr Val Ala Ser Glu Pro Pro Val Lys 
        355                 360                 365             


Leu Val Pro Pro Pro Val Glu Ser Val Ser Gln Ala Thr Ile Val Met 
    370                 375                 380                 


Met Pro Ala Leu Pro Ala Pro Ser Ser Ala Pro Ala Val Ser Thr Thr 
385                 390                 395                 400 


Glu Ser Val Ala Pro Val Ser Gln Pro Asp Asn Cys Val Pro Met Glu 
                405                 410                 415     


Ala Val Gly Asp Pro His Thr Val Thr Val Ser Met Asp Ser Ser Glu 
            420                 425                 430         


Ile Ser Met Ile Ile Asn Ser Ile Lys Glu Glu Cys Phe Arg Ser Gly 
        435                 440                 445             


Val Ala Glu Ala Pro Val Gly Ser Lys Ala Pro Ser Ile Asp Gly Lys 
    450                 455                 460                 


Glu Glu Leu Asp Leu Ala Glu Lys Met Asp Ile Ala Val Ser Tyr Thr 
465                 470                 475                 480 


Gly Glu Glu Leu Asp Phe Glu Thr Val Gly Asp Ile Ile Ala Ile Ile 
                485                 490                 495     


Glu Asp Lys Val Asp Asp His Pro Glu Val Leu Asp Val Ala Ala Val 
            500                 505                 510         


Glu Ala Ala Leu Ser Phe Cys Glu Glu Asn Asp Asp Pro Gln Ser Leu 
        515                 520                 525             


Pro Gly Pro Trp Glu His Pro Ile Gln Gln Glu Arg Asp Lys Pro Val 
    530                 535                 540                 


Pro Leu Pro Ala Pro Glu Met Thr Val Lys Gln Glu Arg Leu Asp Phe 
545                 550                 555                 560 


Glu Glu Thr Glu Asn Lys Gly Ile His Glu Leu Val Asp Ile Arg Glu 
                565                 570                 575     


Pro Ser Ala Glu Ile Lys Val Glu Pro Ala Glu Pro Glu Pro Val Ile 
            580                 585                 590         


Ser Gly Ala Glu Ile Val Ala Gly Val Val Pro Ala Thr Ser Met Glu 
        595                 600                 605             


Pro Pro Glu Leu Arg Ser Gln Asp Leu Asp Glu Glu Leu Gly Ser Thr 
    610                 615                 620                 


Ala Ala Gly Glu Ile Val Glu Ala Asp Val Ala Ile Gly Lys Gly Asp 
625                 630                 635                 640 


Glu Thr Pro Leu Thr Asn Val Lys Thr Glu Ala Ser Pro Glu Ser Met 
                645                 650                 655     


Leu Ser Pro Ser His Gly Ser Asn Pro Ile Glu Asp Pro Leu Glu Ala 
            660                 665                 670         


Glu Thr Gln His Lys Phe Glu Met Ser Asp Ser Leu Lys Glu Glu Ser 
        675                 680                 685             


Gly Thr Ile Phe Gly Ser Gln Ile Lys Asp Ala Pro Gly Glu Asp Glu 
    690                 695                 700                 


Glu Glu Asp Gly Val Ser Glu Ala Ala Ser Leu Glu Glu Pro Lys Glu 
705                 710                 715                 720 


Glu Asp Gln Gly Glu Gly Tyr Leu Ser Glu Met Asp Asn Glu Pro Pro 
                725                 730                 735     


Val Ser Glu Ser Asp Asp Gly Phe Ser Ile His Asn Ala Thr Leu Gln 
            740                 745                 750         


Ser His Thr Leu Ala Asp Ser Ile Pro Ser Ser Pro Ala Ser Ser Gln 
        755                 760                 765             


Phe Ser Val Cys Ser Glu Asp Gln Glu Ala Ile Gln Ala Gln Lys Ile 
    770                 775                 780                 


Trp Lys Lys Ala Ile Met Leu Val Trp Arg Ala Ala Ala Asn His Arg 
785                 790                 795                 800 


Tyr Ala Asn Val Phe Leu Gln Pro Val Thr Asp Asp Ile Ala Pro Gly 
                805                 810                 815     


Tyr His Ser Ile Val Gln Arg Pro Met Asp Leu Ser Thr Ile Lys Lys 
            820                 825                 830         


Asn Ile Glu Asn Gly Leu Ile Arg Ser Thr Ala Glu Phe Gln Arg Asp 
        835                 840                 845             


Ile Met Leu Met Phe Gln Asn Ala Val Met Tyr Asn Ser Ser Asp His 
    850                 855                 860                 


Asp Val Tyr His Met Ala Val Glu Met Gln Arg Asp Val Leu Glu Gln 
865                 870                 875                 880 


Ile Gln Gln Phe Leu Ala Thr Gln Leu Ile Met Gln Thr Ser Glu Ser 
                885                 890                 895     


Gly Ile Ser Ala Lys Ser Leu Arg Gly Arg Asp Ser Thr Arg Lys Gln 
            900                 905                 910         


Asp Ala Ser Glu Lys Asp Ser Val Pro Met Gly Ser Pro Ala Phe Leu 
        915                 920                 925             


Leu Ser Leu Phe Asp Gly Gly Thr Arg Gly Arg Arg Cys Ala Ile Glu 
    930                 935                 940                 


Ala Asp Met Lys Met Lys Lys 
945                 950     


<210>  1142
<211>  4074
<212>  DNA
<213>  Homosapiens

<400>  1142
gggtttcggc ccttccagac cgtctctcct cagggttgga gacttcgggg ccaagatggc     60

gacgggaacg ggcaaacaca agctgctaag cactggcccc acagagccat ggtccatccg    120

agagaagcta tgtttagcat cttctgtcat gagaagtggc gatcaaaatt gggtatcagt    180

tagcagagca atcaagccct ttgcagaacc tggccgccct ccagactggt tctctcaaaa    240

acattgtgct tcccagtact cggagctttt agagaccact gagacaccaa aacggaaacg    300

aggtgaaaag ggagaagtgg tggaaactgt tgaagatgtt attgttcgga aattgactgc    360

tgagcgagtt gaagaactaa agaaagtgat aaaggaaacc caggagagat atagacggct    420

aaagagagat gcagaactaa ttcaagctgg acacatggac agcagactgg atgagctttg    480

caatgacatt gcaacgaaaa agaaattgga agaagaggag gctgaagtaa agaggaaggc    540

tacagatgct gcataccagg ctcgtcaagc agtaaaaaca cccccccgga ggttacccac    600

tgtgatggtt cgctctccta tagattctgc ctccccagga ggtgattatc cacttgggga    660

cttgactcca accactatgg aagaggctac ctctggggtc aatgagagtg aaatggctgt    720

ggcttctggc cacctgaaca gtacaggtgt cctcctggag gtaggcgggg tccttcccat    780

gatacatggt ggggagatac agcaaacacc caatactgtt gcagcctccc ctgctgcatc    840

aggtgctccc actctttccc ggcttttaga agctggtcct acacagttca ccacacctct    900

tgcttccttc actactgttg ccagtgagcc tccagttaaa cttgtgccac cccctgtaga    960

gtctgtgtcc caagctacca ttgtcatgat gcctgcgctg ccagcaccat cctctgctcc   1020

ggctgtctcc actactgaaa gtgtagctcc agtgagtcaa cccgacaact gtgttcccat   1080

ggaggctgtg ggggatccac atactgtgac tgtttccatg gacagcagtg aaatatccat   1140

gatcatcaat tctatcaaag aagagtgttt tcgatcaggg gtagcagagg ctcctgttgg   1200

atcaaaggct cccagcatag atgggaagga agaattagat ctggctgaga agatggatat   1260

tgctgtgtct tacacaggtg aagagctgga ttttgagact gttggagaca tcattgccat   1320

cattgaggac aaggtagatg atcatcctga agtgctggat gtggcagcag tggaagcagc   1380

actgtcattt tgtgaagaaa atgatgatcc tcagtccctg cctggcccct gggagcatcc   1440

tatccagcag gagcgggaca agccagtacc tctccctgca ccagaaatga cggtcaagca   1500

agagagactg gactttgagg aaacggaaaa caagggaata catgaactgg tggacatcag   1560

ggagcccagt gcagagatca aggtggaacc tgcagaacca gagccagtca tttcaggagc   1620

cgaaatagta gctggagttg ttccagccac aagtatggag ccaccagaac tcaggagtca   1680

ggacttagat gaggaactgg gaagtactgc agctggagag attgttgaag cagatgttgc   1740

cattgggaaa ggcgatgaga ctccacttac aaatgtgaag acagaggcat cccctgaaag   1800

catgttgtct ccatcacatg gctcaaatcc cattgaagat cctttagagg cagagactca   1860

gcacaagttt gaaatgtcag actcattgaa agaagaatca gggactattt ttggaagcca   1920

gataaaggat gccccaggtg aggatgagga ggaagatggt gtcagtgaag cggccagcct   1980

agaggagcct aaggaagagg atcaaggaga aggctacttg tcagaaatgg ataatgaacc   2040

tcctgtgagc gagagtgatg atggcttcag catacacaat gctacactgc agtcacacac   2100

actggcagac tccatcccca gcagccctgc ttcttcacag ttctctgtct gtagtgagga   2160

tcaggaagct attcaggcac agaaaatttg gaagaaagcc atcatgcttg tatggagagc   2220

tgcagctaat cataggtatg ccaatgtctt cctgcagcct gttacagatg acatagcacc   2280

tggctaccac agcattgtgc agaggcctat ggatttgtca actattaaga aaaacataga   2340

aaatggactg atccgaagca cagctgaatt tcagcgtgac attatgctga tgtttcagaa   2400

tgctgtaatg tacaatagct cagaccatga tgtctatcac atggcagtgg agatgcagcg   2460

agatgtcttg gaacagatcc agcaattctt ggccacgcag ttgattatgc aaacatccga   2520

gtctgggatc agtgctaaaa gtcttcgagg gagagattct acccgcaaac aggatgcttc   2580

agagaaggac agtgtcccaa tgggctctcc tgccttcctt ctctctctct ttatgggaca   2640

cgagtgggtt tggctggatt ctgaacaaga tcatcccaat gactctgagt tgagcaatga   2700

ctgcaggtcc ctcttcagct catgggactc cagtctggat cttgatgtgg gcaactggag   2760

ggaaactgag gatccagagg ctgaggaact agaggaaagc agcccggaga gagaacctag   2820

tgaactgctt gttggggatg gaggcagtga ggaatctcag gaagcggcaa ggaaagccag   2880

ccaccagaac ctcctccact ttctctctga ggtagcttat ttaatggagc ccttgtgcat   2940

cagcagcaac gaatcaagtg aaggctgctg ccctccatct ggtaccagac aagaaggaag   3000

ggaaattaaa gctagcgaag gagaaaggga gctctgcaga gagactgaag agctttcagc   3060

taaaggagac cccttagtag ctgaaaagcc actgggagaa aatggaaagc cagaggtggc   3120

ttcagctccc tcagttattt gtacagttca gggactactc acagagagtg aagaggggga   3180

ggctcagcaa gaatccaaag gggaggacca gggtgaagta tatgtgtcag agatggaaga   3240

ccagccccct tcaggcgagt gtgatgatgc ctttaacatt aaggagactc ccttggtgga   3300

tacacttttc agccatgcta cctcctcaaa gctgactgat ctaagccagg atgaccctgt   3360

tcaggatcat ttgctattta agaagactct cctgccagtc tggaagatga ttgccagtca   3420

caggttcagc agtccatttc tgaagcctgt gtcagaaagg caggccccag ggtacaagga   3480

tgtggtgaaa agacccatgg acttaactag cctgaagaga aatctctcta agggtcggat   3540

tcgcaccatg gcccaattcc tgcgagacct gatgctgatg ttccaaaatg ctgtaatgta   3600

caatgactct gatcatcatg tataccatat ggctgtggag atgcggcgag aagtcctgga   3660

gcagattcag gtactgaata tctggttaga caaaagaaaa ggctcaagta gtctggaagg   3720

agaaccagct aacccagtgg atgatggaaa acctgttttc taacctggag ctgctatcct   3780

gactttttct agagtttgaa tctctcccgg aactctgacc tagagaggat cctggtactt   3840

ctttgccatg tcctcatttt cttttccaac aagaataata ccttaactca caaccaacga   3900

gtcaaagatg catgtggaca taatataaag aaaaaaaggg gaagctgagg tttggattta   3960

tgccataaat gttgcccaca tctttgttcc atcggcttga tttaaagaca attccattag   4020

atcttttcta agccttttac tctataaata aatgtattta cacaataaaa aaaa         4074


<210>  1143
<211>  1235
<212>  PRT
<213>  Homosapiens

<400>  1143

Met Ala Thr Gly Thr Gly Lys His Lys Leu Leu Ser Thr Gly Pro Thr 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro 
        35                  40                  45              


Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys 
    50                  55                  60                  


Ala Ser Gln Tyr Ser Glu Leu Leu Glu Thr Thr Glu Thr Pro Lys Arg 
65                  70                  75                  80  


Lys Arg Gly Glu Lys Gly Glu Val Val Glu Thr Val Glu Asp Val Ile 
                85                  90                  95      


Val Arg Lys Leu Thr Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile 
            100                 105                 110         


Lys Glu Thr Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu 
        115                 120                 125             


Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp 
    130                 135                 140                 


Ile Ala Thr Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg 
145                 150                 155                 160 


Lys Ala Thr Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Thr Pro 
                165                 170                 175     


Pro Arg Arg Leu Pro Thr Val Met Val Arg Ser Pro Ile Asp Ser Ala 
            180                 185                 190         


Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Thr Pro Thr Thr Met 
        195                 200                 205             


Glu Glu Ala Thr Ser Gly Val Asn Glu Ser Glu Met Ala Val Ala Ser 
    210                 215                 220                 


Gly His Leu Asn Ser Thr Gly Val Leu Leu Glu Val Gly Gly Val Leu 
225                 230                 235                 240 


Pro Met Ile His Gly Gly Glu Ile Gln Gln Thr Pro Asn Thr Val Ala 
                245                 250                 255     


Ala Ser Pro Ala Ala Ser Gly Ala Pro Thr Leu Ser Arg Leu Leu Glu 
            260                 265                 270         


Ala Gly Pro Thr Gln Phe Thr Thr Pro Leu Ala Ser Phe Thr Thr Val 
        275                 280                 285             


Ala Ser Glu Pro Pro Val Lys Leu Val Pro Pro Pro Val Glu Ser Val 
    290                 295                 300                 


Ser Gln Ala Thr Ile Val Met Met Pro Ala Leu Pro Ala Pro Ser Ser 
305                 310                 315                 320 


Ala Pro Ala Val Ser Thr Thr Glu Ser Val Ala Pro Val Ser Gln Pro 
                325                 330                 335     


Asp Asn Cys Val Pro Met Glu Ala Val Gly Asp Pro His Thr Val Thr 
            340                 345                 350         


Val Ser Met Asp Ser Ser Glu Ile Ser Met Ile Ile Asn Ser Ile Lys 
        355                 360                 365             


Glu Glu Cys Phe Arg Ser Gly Val Ala Glu Ala Pro Val Gly Ser Lys 
    370                 375                 380                 


Ala Pro Ser Ile Asp Gly Lys Glu Glu Leu Asp Leu Ala Glu Lys Met 
385                 390                 395                 400 


Asp Ile Ala Val Ser Tyr Thr Gly Glu Glu Leu Asp Phe Glu Thr Val 
                405                 410                 415     


Gly Asp Ile Ile Ala Ile Ile Glu Asp Lys Val Asp Asp His Pro Glu 
            420                 425                 430         


Val Leu Asp Val Ala Ala Val Glu Ala Ala Leu Ser Phe Cys Glu Glu 
        435                 440                 445             


Asn Asp Asp Pro Gln Ser Leu Pro Gly Pro Trp Glu His Pro Ile Gln 
    450                 455                 460                 


Gln Glu Arg Asp Lys Pro Val Pro Leu Pro Ala Pro Glu Met Thr Val 
465                 470                 475                 480 


Lys Gln Glu Arg Leu Asp Phe Glu Glu Thr Glu Asn Lys Gly Ile His 
                485                 490                 495     


Glu Leu Val Asp Ile Arg Glu Pro Ser Ala Glu Ile Lys Val Glu Pro 
            500                 505                 510         


Ala Glu Pro Glu Pro Val Ile Ser Gly Ala Glu Ile Val Ala Gly Val 
        515                 520                 525             


Val Pro Ala Thr Ser Met Glu Pro Pro Glu Leu Arg Ser Gln Asp Leu 
    530                 535                 540                 


Asp Glu Glu Leu Gly Ser Thr Ala Ala Gly Glu Ile Val Glu Ala Asp 
545                 550                 555                 560 


Val Ala Ile Gly Lys Gly Asp Glu Thr Pro Leu Thr Asn Val Lys Thr 
                565                 570                 575     


Glu Ala Ser Pro Glu Ser Met Leu Ser Pro Ser His Gly Ser Asn Pro 
            580                 585                 590         


Ile Glu Asp Pro Leu Glu Ala Glu Thr Gln His Lys Phe Glu Met Ser 
        595                 600                 605             


Asp Ser Leu Lys Glu Glu Ser Gly Thr Ile Phe Gly Ser Gln Ile Lys 
    610                 615                 620                 


Asp Ala Pro Gly Glu Asp Glu Glu Glu Asp Gly Val Ser Glu Ala Ala 
625                 630                 635                 640 


Ser Leu Glu Glu Pro Lys Glu Glu Asp Gln Gly Glu Gly Tyr Leu Ser 
                645                 650                 655     


Glu Met Asp Asn Glu Pro Pro Val Ser Glu Ser Asp Asp Gly Phe Ser 
            660                 665                 670         


Ile His Asn Ala Thr Leu Gln Ser His Thr Leu Ala Asp Ser Ile Pro 
        675                 680                 685             


Ser Ser Pro Ala Ser Ser Gln Phe Ser Val Cys Ser Glu Asp Gln Glu 
    690                 695                 700                 


Ala Ile Gln Ala Gln Lys Ile Trp Lys Lys Ala Ile Met Leu Val Trp 
705                 710                 715                 720 


Arg Ala Ala Ala Asn His Arg Tyr Ala Asn Val Phe Leu Gln Pro Val 
                725                 730                 735     


Thr Asp Asp Ile Ala Pro Gly Tyr His Ser Ile Val Gln Arg Pro Met 
            740                 745                 750         


Asp Leu Ser Thr Ile Lys Lys Asn Ile Glu Asn Gly Leu Ile Arg Ser 
        755                 760                 765             


Thr Ala Glu Phe Gln Arg Asp Ile Met Leu Met Phe Gln Asn Ala Val 
    770                 775                 780                 


Met Tyr Asn Ser Ser Asp His Asp Val Tyr His Met Ala Val Glu Met 
785                 790                 795                 800 


Gln Arg Asp Val Leu Glu Gln Ile Gln Gln Phe Leu Ala Thr Gln Leu 
                805                 810                 815     


Ile Met Gln Thr Ser Glu Ser Gly Ile Ser Ala Lys Ser Leu Arg Gly 
            820                 825                 830         


Arg Asp Ser Thr Arg Lys Gln Asp Ala Ser Glu Lys Asp Ser Val Pro 
        835                 840                 845             


Met Gly Ser Pro Ala Phe Leu Leu Ser Leu Phe Met Gly His Glu Trp 
    850                 855                 860                 


Val Trp Leu Asp Ser Glu Gln Asp His Pro Asn Asp Ser Glu Leu Ser 
865                 870                 875                 880 


Asn Asp Cys Arg Ser Leu Phe Ser Ser Trp Asp Ser Ser Leu Asp Leu 
                885                 890                 895     


Asp Val Gly Asn Trp Arg Glu Thr Glu Asp Pro Glu Ala Glu Glu Leu 
            900                 905                 910         


Glu Glu Ser Ser Pro Glu Arg Glu Pro Ser Glu Leu Leu Val Gly Asp 
        915                 920                 925             


Gly Gly Ser Glu Glu Ser Gln Glu Ala Ala Arg Lys Ala Ser His Gln 
    930                 935                 940                 


Asn Leu Leu His Phe Leu Ser Glu Val Ala Tyr Leu Met Glu Pro Leu 
945                 950                 955                 960 


Cys Ile Ser Ser Asn Glu Ser Ser Glu Gly Cys Cys Pro Pro Ser Gly 
                965                 970                 975     


Thr Arg Gln Glu Gly Arg Glu Ile Lys Ala Ser Glu Gly Glu Arg Glu 
            980                 985                 990         


Leu Cys Arg Glu Thr Glu Glu Leu  Ser Ala Lys Gly Asp  Pro Leu Val 
        995                 1000                 1005             


Ala Glu  Lys Pro Leu Gly Glu  Asn Gly Lys Pro Glu  Val Ala Ser 
    1010                 1015                 1020             


Ala Pro  Ser Val Ile Cys Thr  Val Gln Gly Leu Leu  Thr Glu Ser 
    1025                 1030                 1035             


Glu Glu  Gly Glu Ala Gln Gln  Glu Ser Lys Gly Glu  Asp Gln Gly 
    1040                 1045                 1050             


Glu Val  Tyr Val Ser Glu Met  Glu Asp Gln Pro Pro  Ser Gly Glu 
    1055                 1060                 1065             


Cys Asp  Asp Ala Phe Asn Ile  Lys Glu Thr Pro Leu  Val Asp Thr 
    1070                 1075                 1080             


Leu Phe  Ser His Ala Thr Ser  Ser Lys Leu Thr Asp  Leu Ser Gln 
    1085                 1090                 1095             


Asp Asp  Pro Val Gln Asp His  Leu Leu Phe Lys Lys  Thr Leu Leu 
    1100                 1105                 1110             


Pro Val  Trp Lys Met Ile Ala  Ser His Arg Phe Ser  Ser Pro Phe 
    1115                 1120                 1125             


Leu Lys  Pro Val Ser Glu Arg  Gln Ala Pro Gly Tyr  Lys Asp Val 
    1130                 1135                 1140             


Val Lys  Arg Pro Met Asp Leu  Thr Ser Leu Lys Arg  Asn Leu Ser 
    1145                 1150                 1155             


Lys Gly  Arg Ile Arg Thr Met  Ala Gln Phe Leu Arg  Asp Leu Met 
    1160                 1165                 1170             


Leu Met  Phe Gln Asn Ala Val  Met Tyr Asn Asp Ser  Asp His His 
    1175                 1180                 1185             


Val Tyr  His Met Ala Val Glu  Met Arg Arg Glu Val  Leu Glu Gln 
    1190                 1195                 1200             


Ile Gln  Val Leu Asn Ile Trp  Leu Asp Lys Arg Lys  Gly Ser Ser 
    1205                 1210                 1215             


Ser Leu  Glu Gly Glu Pro Ala  Asn Pro Val Asp Asp  Gly Lys Pro 
    1220                 1225                 1230             


Val Phe  
    1235 


<210>  1144
<211>  3086
<212>  DNA
<213>  Homosapiens

<400>  1144
gggtttcggc ccttccagac cgtctctcct cagggttgga gacttcgggg ccaagatggc     60

gacgggaacg ggcaaacaca agctgctaag cactggcccc acagagccat ggtccatccg    120

agagaagcta tgtttagcat cttctgtcat gagaagtggc gatcaaaatt gggtatcagt    180

tagcagagca atcaagccct ttgcagaacc tggccgccct ccagactggt tctctcaaaa    240

acattgtgct tcccagtact cggagctttt agagaccact gagacaccaa aacggaaacg    300

aggtgaaaag ggagaagtgg tggaaactgt tgaagatgtt attgttcgga aattgactgc    360

tgagcgagtt gaagaactaa agaaagtgat aaaggaaacc caggagagat atagacggct    420

aaagagagat gcagaactaa ttcaagctgg acacatggac agcagactgg atgagctttg    480

caatgacatt gaaaaagaaa ttggaagaag aggaggctga agtaaagagg aaggctacag    540

atgctgcata ccaggctcgt caagcagtaa aaacaccccc ccggaggtta cccactgtga    600

tggttcgctc tcctatagat tctgcctccc caggaggtga ttatccactt ggggacttga    660

ctccaaccac tatggaagag gctacctctg gggtaacccc cgggactttg ccgagtaccc    720

cagtcacctc gtttcctggg attcctgaca cccttcctcc aggctctgca cccttagaag    780

cccccatgac cccagtaaca gatgattcac cccagaaaaa gatgcttgga cagaaagcaa    840

ctccaccccc ctcccctctg ctgtcagagc tcttgaagaa gggcagcctc ctgcctacta    900

gccccagact ggtcaatgag agtgaaatgg ctgtggcttc tggccacctg aacagtacag    960

gtgtcctcct ggaggtaggc ggggtccttc ccatgataca tggtggggag atacagcaaa   1020

cacccaatac tgttgcagcc tcccctgctg catcagagtc tgtgtcccaa gctaccattg   1080

tcatgatgcc tgcgctgcca gcaccatcct ctgctccggc tgtctccact actgaaagtg   1140

tagctccagt gagtcaaccc gacaactgtg ttcccatgga ggctgtgggg gatccacata   1200

ctgtgactgt ttccatggac agcagtgaaa tatccatgat catcaattct atcaaagaag   1260

agtgttttcg atcaggggta gcagaggctc ctgttggatc aaaggctccc agcatagatg   1320

ggaaggaaga attagatctg gctgagaaga tggatattgc tgtgtcttac acaggtgaag   1380

agctggattt tgagactgtt ggagacatca ttgccatcat tgaggacaag gtagatgatc   1440

atcctgaagt gctggatgtg gcagcagtgg aagcagcact gtcattttgt gaagaaaatg   1500

atgatcctca gtccctgcct ggcccctggg agcatcctat ccagcaggag cgggacaagc   1560

cagtacctct ccctgcacca gaaatgacgg tcaagcaaga gagactggac tttgaggaaa   1620

cggaaaacaa gggaatacat gaactggtgg acatcaggga gcccagtgca gagatcaagg   1680

tggaacctgc agaaccagag ccagtcattt caggagccga aatagtagct ggagttgttc   1740

cagccacaag tatggagcca ccagaactca ggagtcagga cttagatgag gaactgggaa   1800

gtactgcagc tggagagatt gttgaagcag atgttgccat tgggaaaggc gatgagactc   1860

cacttacaaa tgtgaagaca gaggcatccc ctgaaagcat gttgtctcca tcacatggct   1920

caaatcccat tgaagatcct ttagaggcag agactcagca caagtttgaa atgtcagact   1980

cattgaaaga agaatcaggg actatttttg gaagccagat aaaggatgcc ccaggtgagg   2040

atgaggagga agatggtgtc agtgaagcgg ccagcctaga ggagcctaag gaagaggatc   2100

aaggagaagg ctacttgtca gaaatggata atgaacctcc tgtgagcgag agtgatgatg   2160

gcttcagcat acacaatgct acactgcagt cacacacact ggcagactcc atccccagca   2220

gccctgcttc ttcacagttc tctgtctgta gtgaggatca ggaagctatt caggcacaga   2280

aaatttggaa gaaagccatc atgcttgtat ggagagctgc agctaatcat aggtatgcca   2340

atgtcttcct gcagcctgtt acagatgaca tagcacctgg ctaccacagc attgtgcaga   2400

ggcctatgga tttgtcaact attaagaaaa acatagaaaa tggactgatc cgaagcacag   2460

ctgaatttca gcgtgacatt atgctgatgt ttcagaatgc tgtaatgtac aatagctcag   2520

accatgatgt ctatcacatg gcagtggaga tgcagcgaga tgtcttggaa cagatccagc   2580

aattcttggc cacgcagttg attatgcaaa catccgagtc tgggatcagt gctaaaagtc   2640

ttcgagggag agattctacc cgcaaacagg atgcttcaga gaaggatgga ggaaccaggg   2700

gacgccgctg tgccattgaa gcagatatga agatgaaaaa gtgaagcctc agagttaccc   2760

tctttgagcc gaacctaaaa taaaagtaaa caagatagag cttgggcttg cgggcccagt   2820

tccagaggtg gaagttacag aagaggaggt acctgggcca cacgacatga gctggaaaat   2880

ctctcttaga gagttggagt agcacaattg cctgttttag ggcagaaacc atgggctatg   2940

ttaatgtcct aatgtgtagc tagcagatcg tagctagttt gtattgtctt gtcaattgta   3000

cagacttttt aaaaaaaaca accaccagtg aaatgtgtgt gtatacaata aactgaaaaa   3060

aaaaactaaa aaaaaaaaaa aaaaaa                                        3086


<210>  1145
<211>  757
<212>  PRT
<213>  Homosapiens

<400>  1145

Met Ser Phe Ala Met Thr Leu Lys Lys Lys Leu Glu Glu Glu Glu Ala 
1               5                   10                  15      


Glu Val Lys Arg Lys Ala Thr Asp Ala Ala Tyr Gln Ala Arg Gln Ala 
            20                  25                  30          


Val Lys Thr Pro Pro Arg Arg Leu Pro Thr Val Met Val Arg Ser Pro 
        35                  40                  45              


Ile Asp Ser Ala Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Thr 
    50                  55                  60                  


Pro Thr Thr Met Glu Glu Ala Thr Ser Gly Val Thr Pro Gly Thr Leu 
65                  70                  75                  80  


Pro Ser Thr Pro Val Thr Ser Phe Pro Gly Ile Pro Asp Thr Leu Pro 
                85                  90                  95      


Pro Gly Ser Ala Pro Leu Glu Ala Pro Met Thr Pro Val Thr Asp Asp 
            100                 105                 110         


Ser Pro Gln Lys Lys Met Leu Gly Gln Lys Ala Thr Pro Pro Pro Ser 
        115                 120                 125             


Pro Leu Leu Ser Glu Leu Leu Lys Lys Gly Ser Leu Leu Pro Thr Ser 
    130                 135                 140                 


Pro Arg Leu Val Asn Glu Ser Glu Met Ala Val Ala Ser Gly His Leu 
145                 150                 155                 160 


Asn Ser Thr Gly Val Leu Leu Glu Val Gly Gly Val Leu Pro Met Ile 
                165                 170                 175     


His Gly Gly Glu Ile Gln Gln Thr Pro Asn Thr Val Ala Ala Ser Pro 
            180                 185                 190         


Ala Ala Ser Glu Ser Val Ser Gln Ala Thr Ile Val Met Met Pro Ala 
        195                 200                 205             


Leu Pro Ala Pro Ser Ser Ala Pro Ala Val Ser Thr Thr Glu Ser Val 
    210                 215                 220                 


Ala Pro Val Ser Gln Pro Asp Asn Cys Val Pro Met Glu Ala Val Gly 
225                 230                 235                 240 


Asp Pro His Thr Val Thr Val Ser Met Asp Ser Ser Glu Ile Ser Met 
                245                 250                 255     


Ile Ile Asn Ser Ile Lys Glu Glu Cys Phe Arg Ser Gly Val Ala Glu 
            260                 265                 270         


Ala Pro Val Gly Ser Lys Ala Pro Ser Ile Asp Gly Lys Glu Glu Leu 
        275                 280                 285             


Asp Leu Ala Glu Lys Met Asp Ile Ala Val Ser Tyr Thr Gly Glu Glu 
    290                 295                 300                 


Leu Asp Phe Glu Thr Val Gly Asp Ile Ile Ala Ile Ile Glu Asp Lys 
305                 310                 315                 320 


Val Asp Asp His Pro Glu Val Leu Asp Val Ala Ala Val Glu Ala Ala 
                325                 330                 335     


Leu Ser Phe Cys Glu Glu Asn Asp Asp Pro Gln Ser Leu Pro Gly Pro 
            340                 345                 350         


Trp Glu His Pro Ile Gln Gln Glu Arg Asp Lys Pro Val Pro Leu Pro 
        355                 360                 365             


Ala Pro Glu Met Thr Val Lys Gln Glu Arg Leu Asp Phe Glu Glu Thr 
    370                 375                 380                 


Glu Asn Lys Gly Ile His Glu Leu Val Asp Ile Arg Glu Pro Ser Ala 
385                 390                 395                 400 


Glu Ile Lys Val Glu Pro Ala Glu Pro Glu Pro Val Ile Ser Gly Ala 
                405                 410                 415     


Glu Ile Val Ala Gly Val Val Pro Ala Thr Ser Met Glu Pro Pro Glu 
            420                 425                 430         


Leu Arg Ser Gln Asp Leu Asp Glu Glu Leu Gly Ser Thr Ala Ala Gly 
        435                 440                 445             


Glu Ile Val Glu Ala Asp Val Ala Ile Gly Lys Gly Asp Glu Thr Pro 
    450                 455                 460                 


Leu Thr Asn Val Lys Thr Glu Ala Ser Pro Glu Ser Met Leu Ser Pro 
465                 470                 475                 480 


Ser His Gly Ser Asn Pro Ile Glu Asp Pro Leu Glu Ala Glu Thr Gln 
                485                 490                 495     


His Lys Phe Glu Met Ser Asp Ser Leu Lys Glu Glu Ser Gly Thr Ile 
            500                 505                 510         


Phe Gly Ser Gln Ile Lys Asp Ala Pro Gly Glu Asp Glu Glu Glu Asp 
        515                 520                 525             


Gly Val Ser Glu Ala Ala Ser Leu Glu Glu Pro Lys Glu Glu Asp Gln 
    530                 535                 540                 


Gly Glu Gly Tyr Leu Ser Glu Met Asp Asn Glu Pro Pro Val Ser Glu 
545                 550                 555                 560 


Ser Asp Asp Gly Phe Ser Ile His Asn Ala Thr Leu Gln Ser His Thr 
                565                 570                 575     


Leu Ala Asp Ser Ile Pro Ser Ser Pro Ala Ser Ser Gln Phe Ser Val 
            580                 585                 590         


Cys Ser Glu Asp Gln Glu Ala Ile Gln Ala Gln Lys Ile Trp Lys Lys 
        595                 600                 605             


Ala Ile Met Leu Val Trp Arg Ala Ala Ala Asn His Arg Tyr Ala Asn 
    610                 615                 620                 


Val Phe Leu Gln Pro Val Thr Asp Asp Ile Ala Pro Gly Tyr His Ser 
625                 630                 635                 640 


Ile Val Gln Arg Pro Met Asp Leu Ser Thr Ile Lys Lys Asn Ile Glu 
                645                 650                 655     


Asn Gly Leu Ile Arg Ser Thr Ala Glu Phe Gln Arg Asp Ile Met Leu 
            660                 665                 670         


Met Phe Gln Asn Ala Val Met Tyr Asn Ser Ser Asp His Asp Val Tyr 
        675                 680                 685             


His Met Ala Val Glu Met Gln Arg Asp Val Leu Glu Gln Ile Gln Gln 
    690                 695                 700                 


Phe Leu Ala Thr Gln Leu Ile Met Gln Thr Ser Glu Ser Gly Ile Ser 
705                 710                 715                 720 


Ala Lys Ser Leu Arg Gly Arg Asp Ser Thr Arg Lys Gln Asp Ala Ser 
                725                 730                 735     


Glu Lys Asp Gly Gly Thr Arg Gly Arg Arg Cys Ala Ile Glu Ala Asp 
            740                 745                 750         


Met Lys Met Lys Lys 
        755         


<210>  1146
<211>  2972
<212>  DNA
<213>  Homosapiens

<400>  1146
tcttcggacc taggctgccc tgccgtcatg tcgcaaggga tcctttctcc gccagcgggc     60

ttgctgtccg atgacgatgt cgtagtttct cccatgtttg agtccacagc tgcagatttg    120

gggtctgtgg tacgcaagaa cctgctatca gactgctctg tcgtctctac ctccctagag    180

gacaagcagc aggttccatc tgaggacagt atggagaagg tgaaagtata cttgagggtt    240

aggcccttgt taccttcaga gttggaacga caggaagatc agggttgtgt ccgtattgag    300

aatgtggaga cccttgttct acaagcaccc aaggactcgt ttgccctgaa gagcaatgaa    360

cggggaattg gccaagccac acacaggttc accttttccc agatctttgg gccagaagtg    420

ggacaggcat ccttcttcaa cctaactgtg aaggagatgg taaaggatgt actcaaaggg    480

cagaactggc tcatctatac atatggagtc actaactcag ggaaaaccca cacgattcaa    540

ggtaccatca aggatggagg gattctcccc cggtccctgg cgctgatctt caatagcctc    600

caaggccaac ttcatccaac acctgatctg aagcccttgc tctccaatga ggtaatctgg    660

ctagacagca agcagatccg acaggaggaa atgaagaagc tgtccctgct aaatggaggc    720

ctccaagagg aggagctgtc cacttccttg aagaggagtg tctacatcga aagtcggata    780

ggtaccagca ccagcttcga cagtggcatt gctgggctct cttctatcag tcagtgtacc    840

agcagtagcc agctggatga aacaagtcat cgatgggcac agccagacac tgccccacta    900

cctgtcccgg caaacattcg cttctccatc tggatctcat tctttgagat ctacaacgaa    960

ctgctttatg acctattaga accgcctagc caacagcgca agaggcagac tttgcggcta   1020

tgcgaggatc aaaatggcaa tccctatgtg aaagatctca actggattca tgtgcaagat   1080

gctgaggagg cctggaagct cctaaaagtg ggtcgtaaga accagagctt tgccagcacc   1140

cacctcaacc agaactccag ccgcagtcac agcatcttct caatcaggat cctacacctt   1200

cagggggaag gagatatagt ccccaagatc agcgagctgt cactctgtga tctggctggc   1260

tcagagcgct gcaaagatca gaagagtggt gaacggttga aggaagcagg aaacattaac   1320

acctctctac acaccctggg ccgctgtatt gctgcccttc gtcaaaacca gcagaaccgg   1380

tcaaagcaga acctggttcc cttccgtgac agcaagttga ctcgagtgtt ccaaggtttc   1440

ttcacaggcc gaggccgttc ctgcatgatt gtcaatgtga atccctgtgc atctacctat   1500

gatgaaactc ttcatgtggc caagttctca gccattgcta gccagcttgt gcatgcccca   1560

cctatgcaac tgggattccc atccctgcac tcgttcatca aggaacatag tcttcaggta   1620

tcccccagct tagagaaagg ggctaaggca gacacaggcc ttgatgatga tattgaaaat   1680

gaagctgaca tctccatgta tggcaaagag gagctcctac aagttgtgga agccatgaag   1740

acactgcttt tgaaggaacg acaggaaaag ctacagctgg agatgcatct ccgagatgaa   1800

atttgcaatg agatggtaga acagatgcaa cagcgggaac agtggtgcag tgaacatttg   1860

gacacccaaa aggaactatt ggaggaaatg tatgaagaaa aactaaatat cctcaaggag   1920

tcactgacaa gtttttacca agaagagatt caggagcggg atgaaaagat tgaagagcta   1980

gaagctctct tgcaggaagc cagacaacag tcagtggccc atcagcaatc agggtctgaa   2040

ttggccctac ggcggtcaca aaggttggca gcttctgcct ccacccagca gcttcaggag   2100

gttaaagcta aattacagca gtgcaaagca gagctaaact ctaccactga agagttgcat   2160

aagtatcaga aaatgttaga accaccaccc tcagccaagc ccttcaccat tgatgtggac   2220

aagaagttag aagagggcca gaagaatata aggctgttgc ggacagagct tcagaaactt   2280

ggtgagtctc tccaatcagc agagagagct tgttgccaca gcactggggc aggaaaactt   2340

cgtcaagcct tgaccacttg tgatgacatc ttaatcaaac aggaccagac tctggctgaa   2400

ctgcagaaca acatggtgct agtgaaactg gaccttcgga agaaggcagc atgtattgct   2460

gagcagtatc atactgtgtt gaaactccaa ggccaggttt ctgccaaaaa gcgccttggt   2520

accaaccagg aaaatcagca accaaaccaa caaccaccag ggaagaaacc attccttcga   2580

aatttacttc cccgaacacc aacctgccaa agctcaacag actgcagccc ttatgcccgg   2640

atcctacgct cacggcgttc ccctttactc aaatctgggc cttttggcaa aaagtactaa   2700

ggctgtgggg aaagagaaga gcagtcatgg ccctgaggtg ggtcagctac tctcctgaag   2760

aaataggtct cttttatgct ttaccatata tcaggaatta tatccaggat gcaatactca   2820

gacactagct tttttctcac ttttgtatta taaccaccta tgtaatctca tgttgttgtt   2880

tttttttatt tacttatatg atttctatgc acacaaaaac agttatatta aagatattat   2940

tgttcacatt ttttattgaa aaaaaaaaaa aa                                 2972


<210>  1147
<211>  890
<212>  PRT
<213>  Homosapiens

<400>  1147

Met Ser Gln Gly Ile Leu Ser Pro Pro Ala Gly Leu Leu Ser Asp Asp 
1               5                   10                  15      


Asp Val Val Val Ser Pro Met Phe Glu Ser Thr Ala Ala Asp Leu Gly 
            20                  25                  30          


Ser Val Val Arg Lys Asn Leu Leu Ser Asp Cys Ser Val Val Ser Thr 
        35                  40                  45              


Ser Leu Glu Asp Lys Gln Gln Val Pro Ser Glu Asp Ser Met Glu Lys 
    50                  55                  60                  


Val Lys Val Tyr Leu Arg Val Arg Pro Leu Leu Pro Ser Glu Leu Glu 
65                  70                  75                  80  


Arg Gln Glu Asp Gln Gly Cys Val Arg Ile Glu Asn Val Glu Thr Leu 
                85                  90                  95      


Val Leu Gln Ala Pro Lys Asp Ser Phe Ala Leu Lys Ser Asn Glu Arg 
            100                 105                 110         


Gly Ile Gly Gln Ala Thr His Arg Phe Thr Phe Ser Gln Ile Phe Gly 
        115                 120                 125             


Pro Glu Val Gly Gln Ala Ser Phe Phe Asn Leu Thr Val Lys Glu Met 
    130                 135                 140                 


Val Lys Asp Val Leu Lys Gly Gln Asn Trp Leu Ile Tyr Thr Tyr Gly 
145                 150                 155                 160 


Val Thr Asn Ser Gly Lys Thr His Thr Ile Gln Gly Thr Ile Lys Asp 
                165                 170                 175     


Gly Gly Ile Leu Pro Arg Ser Leu Ala Leu Ile Phe Asn Ser Leu Gln 
            180                 185                 190         


Gly Gln Leu His Pro Thr Pro Asp Leu Lys Pro Leu Leu Ser Asn Glu 
        195                 200                 205             


Val Ile Trp Leu Asp Ser Lys Gln Ile Arg Gln Glu Glu Met Lys Lys 
    210                 215                 220                 


Leu Ser Leu Leu Asn Gly Gly Leu Gln Glu Glu Glu Leu Ser Thr Ser 
225                 230                 235                 240 


Leu Lys Arg Ser Val Tyr Ile Glu Ser Arg Ile Gly Thr Ser Thr Ser 
                245                 250                 255     


Phe Asp Ser Gly Ile Ala Gly Leu Ser Ser Ile Ser Gln Cys Thr Ser 
            260                 265                 270         


Ser Ser Gln Leu Asp Glu Thr Ser His Arg Trp Ala Gln Pro Asp Thr 
        275                 280                 285             


Ala Pro Leu Pro Val Pro Ala Asn Ile Arg Phe Ser Ile Trp Ile Ser 
    290                 295                 300                 


Phe Phe Glu Ile Tyr Asn Glu Leu Leu Tyr Asp Leu Leu Glu Pro Pro 
305                 310                 315                 320 


Ser Gln Gln Arg Lys Arg Gln Thr Leu Arg Leu Cys Glu Asp Gln Asn 
                325                 330                 335     


Gly Asn Pro Tyr Val Lys Asp Leu Asn Trp Ile His Val Gln Asp Ala 
            340                 345                 350         


Glu Glu Ala Trp Lys Leu Leu Lys Val Gly Arg Lys Asn Gln Ser Phe 
        355                 360                 365             


Ala Ser Thr His Leu Asn Gln Asn Ser Ser Arg Ser His Ser Ile Phe 
    370                 375                 380                 


Ser Ile Arg Ile Leu His Leu Gln Gly Glu Gly Asp Ile Val Pro Lys 
385                 390                 395                 400 


Ile Ser Glu Leu Ser Leu Cys Asp Leu Ala Gly Ser Glu Arg Cys Lys 
                405                 410                 415     


Asp Gln Lys Ser Gly Glu Arg Leu Lys Glu Ala Gly Asn Ile Asn Thr 
            420                 425                 430         


Ser Leu His Thr Leu Gly Arg Cys Ile Ala Ala Leu Arg Gln Asn Gln 
        435                 440                 445             


Gln Asn Arg Ser Lys Gln Asn Leu Val Pro Phe Arg Asp Ser Lys Leu 
    450                 455                 460                 


Thr Arg Val Phe Gln Gly Phe Phe Thr Gly Arg Gly Arg Ser Cys Met 
465                 470                 475                 480 


Ile Val Asn Val Asn Pro Cys Ala Ser Thr Tyr Asp Glu Thr Leu His 
                485                 490                 495     


Val Ala Lys Phe Ser Ala Ile Ala Ser Gln Leu Val His Ala Pro Pro 
            500                 505                 510         


Met Gln Leu Gly Phe Pro Ser Leu His Ser Phe Ile Lys Glu His Ser 
        515                 520                 525             


Leu Gln Val Ser Pro Ser Leu Glu Lys Gly Ala Lys Ala Asp Thr Gly 
    530                 535                 540                 


Leu Asp Asp Asp Ile Glu Asn Glu Ala Asp Ile Ser Met Tyr Gly Lys 
545                 550                 555                 560 


Glu Glu Leu Leu Gln Val Val Glu Ala Met Lys Thr Leu Leu Leu Lys 
                565                 570                 575     


Glu Arg Gln Glu Lys Leu Gln Leu Glu Met His Leu Arg Asp Glu Ile 
            580                 585                 590         


Cys Asn Glu Met Val Glu Gln Met Gln Gln Arg Glu Gln Trp Cys Ser 
        595                 600                 605             


Glu His Leu Asp Thr Gln Lys Glu Leu Leu Glu Glu Met Tyr Glu Glu 
    610                 615                 620                 


Lys Leu Asn Ile Leu Lys Glu Ser Leu Thr Ser Phe Tyr Gln Glu Glu 
625                 630                 635                 640 


Ile Gln Glu Arg Asp Glu Lys Ile Glu Glu Leu Glu Ala Leu Leu Gln 
                645                 650                 655     


Glu Ala Arg Gln Gln Ser Val Ala His Gln Gln Ser Gly Ser Glu Leu 
            660                 665                 670         


Ala Leu Arg Arg Ser Gln Arg Leu Ala Ala Ser Ala Ser Thr Gln Gln 
        675                 680                 685             


Leu Gln Glu Val Lys Ala Lys Leu Gln Gln Cys Lys Ala Glu Leu Asn 
    690                 695                 700                 


Ser Thr Thr Glu Glu Leu His Lys Tyr Gln Lys Met Leu Glu Pro Pro 
705                 710                 715                 720 


Pro Ser Ala Lys Pro Phe Thr Ile Asp Val Asp Lys Lys Leu Glu Glu 
                725                 730                 735     


Gly Gln Lys Asn Ile Arg Leu Leu Arg Thr Glu Leu Gln Lys Leu Gly 
            740                 745                 750         


Glu Ser Leu Gln Ser Ala Glu Arg Ala Cys Cys His Ser Thr Gly Ala 
        755                 760                 765             


Gly Lys Leu Arg Gln Ala Leu Thr Thr Cys Asp Asp Ile Leu Ile Lys 
    770                 775                 780                 


Gln Asp Gln Thr Leu Ala Glu Leu Gln Asn Asn Met Val Leu Val Lys 
785                 790                 795                 800 


Leu Asp Leu Arg Lys Lys Ala Ala Cys Ile Ala Glu Gln Tyr His Thr 
                805                 810                 815     


Val Leu Lys Leu Gln Gly Gln Val Ser Ala Lys Lys Arg Leu Gly Thr 
            820                 825                 830         


Asn Gln Glu Asn Gln Gln Pro Asn Gln Gln Pro Pro Gly Lys Lys Pro 
        835                 840                 845             


Phe Leu Arg Asn Leu Leu Pro Arg Thr Pro Thr Cys Gln Ser Ser Thr 
    850                 855                 860                 


Asp Cys Ser Pro Tyr Ala Arg Ile Leu Arg Ser Arg Arg Ser Pro Leu 
865                 870                 875                 880 


Leu Lys Ser Gly Pro Phe Gly Lys Lys Tyr 
                885                 890 


<210>  1148
<211>  3160
<212>  DNA
<213>  Homosapiens

<400>  1148
gtggcccgag tcgggaaaat ggctgcgagt acctccatgg tcccggtggc tgtgacggcg     60

gcagtggcgc ctgtcctgtc cataaacagc gatttctcag atttgcggga aattaaaaag    120

caactgctgc ttattgcggg ccttacccgg gagcggggcc tactacacag tagcaaatgg    180

tcggcggagt tggctttctc tctccctgca ttgcctctgg ccgagctgca accgcctccg    240

cctattacag aggaagatgc ccaggatatg gatgcctata ccctggccaa ggcctacttt    300

gacgttaaag agtatgatcg ggcagcacat ttcctgcatg gctgcaatag caagaaagcc    360

tattttctgt atatgtattc cagatatctg tctggagaaa aaaagaagga cgatgaaaca    420

gttgatagct taggccccct ggaaaaagga caagtgaaaa atgaggcgct tagagaattg    480

agagtggagc tcagcaaaaa acaccaagct cgagaacttg atggatttgg actttatctg    540

tatggtgtgg tgcttcgaaa actggacttg gttaaagagg ccattgatgt gtttgtggaa    600

gctactcatg ttttgccctt gcattgggga gcctggttag aactctgtaa cctgatcaca    660

gacaaagaga tgctgaagtt cctgtctttg ccagacacct ggatgaaaga gttttttctg    720

gctcatatat acacagagtt gcagttgata gaggaggccc tgcaaaagta tcagaatctc    780

attgatgtgg gcttctctaa gagctcgtat attgtttccc aaattgcagt tgcctatcac    840

aatatcagag atattgacaa agccctctcc atttttaatg agctaaggaa acaagaccct    900

tacaggattg aaaatatgga cacattctcc aaccttcttt atgtcaggag catgaaatcg    960

gagttgagtt atctggctca taacctctgt gagattgata aatatcgtgt agaaacgtgc   1020

tgtgtaattg gcaattatta cagtttacgt tctcagcatg agaaagcagc cttatatttc   1080

cagagagccc tgaaattaaa tcctcggtat cttggtgcct ggacactaat gggacatgag   1140

tacatggaga tgaagaacac gtctgctgct atccaggctt atagacatgc cattgaggtc   1200

aacaaacggg actacagagc ttggtatggc ctcgggcaga cctatgaaat ccttaagatg   1260

ccattttact gcctttatta ttatagacgg gcccaccagc ttcgacccaa tgattctcgc   1320

atgctggttg ctttaggaga atgttacgag aaactcaatc aactagtgga agccaaaaag   1380

tgttattgga gagcttacgc cgtgggagat gtggagaaaa tggctctggt gaaactggca   1440

aagcttcatg aacagttgac tgagtcagaa caggctgccc agtgttacat caaatatatc   1500

caagatatct attcctgtgg ggaaatagta gaacacttgg aggaaagcac tgcctttcgc   1560

tatctggccc agtactattt taagtgcaaa ctgtgggatg aagcttcaac ttgtgcacaa   1620

aagtgttgtg catttaatga tacccgggaa gaaggtaagg ccttactccg gcaaatccta   1680

cagcttcgga accaaggcga gactcctacc accgaggtgc ctgctccctt tttcctacct   1740

gcttcactct ctgctaacaa tacccccaca cgcagagttt ctccactcaa cttgtcttct   1800

gtcacgccat agttggctac tctcaagcca gcacattgtt agacccatct taattaagcc   1860

ttacctccat gtaaagaaca gcacgtctgt tccaaggacc tcagctcttc ttgtttctac   1920

agatggcaac agctccatag ggacagcttg tataattacc ttcagaggcc aactgacaga   1980

atcctggcag gaacagacat tatcttgcca gttagaagta cttctgtctc acttatgtcc   2040

aaagagtggc tatagatctt ggccttcttc cctgaatgct tttttttttt ggcccccaag   2100

aaagtccctt ttatagcact ttagcacagg caatgctaca ggaacaaagt ttcaatgctg   2160

ctgagagtga aagaaaggag gaaagtctgc cactctaccc tgagctggca gtagggcact   2220

gagtaccctt aggaagaagt cagagcaatg gatacaaatg accttgctct tggatttgct   2280

gagcatgatc cctattctga tgtcagagat taggtttaaa tggaatagag ctatccattt   2340

gttcttactc tctagggaga caatcttcca aaacagtttt gggggggtct tctaaagctt   2400

tcaaattgga agtaacttta ttcaactaga gttgaataaa agaagggcaa aaataatctc   2460

acagagcttg gaactgctga tagcccttac tgagggcaaa agatggctat attgttagct   2520

atactcctac caaagcaagc aaggagatag gattatagat aatttcacgg acatttggaa   2580

ataacattgg tgattataca gacaagaata aactcacttc aagctggtct gttttaataa   2640

attttcaacg taattgtcta tttttttccc tcccatctgc aacagaatac atttttttca   2700

gcctttatct agatgaggta aagggaatca ttcttatggt gctcttggag agtttcaggc   2760

ctgtgcatgt gtgtacagca ggaggtaata tgctataatg tctgctgtaa tatatttgca   2820

cagtagatgc tatggatcat tctgagctca gggtccagac tttattctta ttcccagaat   2880

tttgtgttac gtttttacct cctaacatat gacacttcat cttatattaa ggaaggttta   2940

gaatatctaa tacgacttga attcatttgt tactaagcct tctcaggcaa gctgtatact   3000

agttactggt ctccactgcc atgccttttc aaggttccca tggtccagaa tgatgtttga   3060

ttcttaattt ttctgtccct tttataattt gttttaatga ttttgctaca tttggaattc   3120

aataaaaaat gtgaacaata ataaaaaaaa aaaaaaaaaa                         3160


<210>  1149
<211>  591
<212>  PRT
<213>  Homosapiens

<400>  1149

Met Val Pro Val Ala Val Thr Ala Ala Val Ala Pro Val Leu Ser Ile 
1               5                   10                  15      


Asn Ser Asp Phe Ser Asp Leu Arg Glu Ile Lys Lys Gln Leu Leu Leu 
            20                  25                  30          


Ile Ala Gly Leu Thr Arg Glu Arg Gly Leu Leu His Ser Ser Lys Trp 
        35                  40                  45              


Ser Ala Glu Leu Ala Phe Ser Leu Pro Ala Leu Pro Leu Ala Glu Leu 
    50                  55                  60                  


Gln Pro Pro Pro Pro Ile Thr Glu Glu Asp Ala Gln Asp Met Asp Ala 
65                  70                  75                  80  


Tyr Thr Leu Ala Lys Ala Tyr Phe Asp Val Lys Glu Tyr Asp Arg Ala 
                85                  90                  95      


Ala His Phe Leu His Gly Cys Asn Ser Lys Lys Ala Tyr Phe Leu Tyr 
            100                 105                 110         


Met Tyr Ser Arg Tyr Leu Ser Gly Glu Lys Lys Lys Asp Asp Glu Thr 
        115                 120                 125             


Val Asp Ser Leu Gly Pro Leu Glu Lys Gly Gln Val Lys Asn Glu Ala 
    130                 135                 140                 


Leu Arg Glu Leu Arg Val Glu Leu Ser Lys Lys His Gln Ala Arg Glu 
145                 150                 155                 160 


Leu Asp Gly Phe Gly Leu Tyr Leu Tyr Gly Val Val Leu Arg Lys Leu 
                165                 170                 175     


Asp Leu Val Lys Glu Ala Ile Asp Val Phe Val Glu Ala Thr His Val 
            180                 185                 190         


Leu Pro Leu His Trp Gly Ala Trp Leu Glu Leu Cys Asn Leu Ile Thr 
        195                 200                 205             


Asp Lys Glu Met Leu Lys Phe Leu Ser Leu Pro Asp Thr Trp Met Lys 
    210                 215                 220                 


Glu Phe Phe Leu Ala His Ile Tyr Thr Glu Leu Gln Leu Ile Glu Glu 
225                 230                 235                 240 


Ala Leu Gln Lys Tyr Gln Asn Leu Ile Asp Val Gly Phe Ser Lys Ser 
                245                 250                 255     


Ser Tyr Ile Val Ser Gln Ile Ala Val Ala Tyr His Asn Ile Arg Asp 
            260                 265                 270         


Ile Asp Lys Ala Leu Ser Ile Phe Asn Glu Leu Arg Lys Gln Asp Pro 
        275                 280                 285             


Tyr Arg Ile Glu Asn Met Asp Thr Phe Ser Asn Leu Leu Tyr Val Arg 
    290                 295                 300                 


Ser Met Lys Ser Glu Leu Ser Tyr Leu Ala His Asn Leu Cys Glu Ile 
305                 310                 315                 320 


Asp Lys Tyr Arg Val Glu Thr Cys Cys Val Ile Gly Asn Tyr Tyr Ser 
                325                 330                 335     


Leu Arg Ser Gln His Glu Lys Ala Ala Leu Tyr Phe Gln Arg Ala Leu 
            340                 345                 350         


Lys Leu Asn Pro Arg Tyr Leu Gly Ala Trp Thr Leu Met Gly His Glu 
        355                 360                 365             


Tyr Met Glu Met Lys Asn Thr Ser Ala Ala Ile Gln Ala Tyr Arg His 
    370                 375                 380                 


Ala Ile Glu Val Asn Lys Arg Asp Tyr Arg Ala Trp Tyr Gly Leu Gly 
385                 390                 395                 400 


Gln Thr Tyr Glu Ile Leu Lys Met Pro Phe Tyr Cys Leu Tyr Tyr Tyr 
                405                 410                 415     


Arg Arg Ala His Gln Leu Arg Pro Asn Asp Ser Arg Met Leu Val Ala 
            420                 425                 430         


Leu Gly Glu Cys Tyr Glu Lys Leu Asn Gln Leu Val Glu Ala Lys Lys 
        435                 440                 445             


Cys Tyr Trp Arg Ala Tyr Ala Val Gly Asp Val Glu Lys Met Ala Leu 
    450                 455                 460                 


Val Lys Leu Ala Lys Leu His Glu Gln Leu Thr Glu Ser Glu Gln Ala 
465                 470                 475                 480 


Ala Gln Cys Tyr Ile Lys Tyr Ile Gln Asp Ile Tyr Ser Cys Gly Glu 
                485                 490                 495     


Ile Val Glu His Leu Glu Glu Ser Thr Ala Phe Arg Tyr Leu Ala Gln 
            500                 505                 510         


Tyr Tyr Phe Lys Cys Lys Leu Trp Asp Glu Ala Ser Thr Cys Ala Gln 
        515                 520                 525             


Lys Cys Cys Ala Phe Asn Asp Thr Arg Glu Glu Gly Lys Ala Leu Leu 
    530                 535                 540                 


Arg Gln Ile Leu Gln Leu Arg Asn Gln Gly Glu Thr Pro Thr Thr Glu 
545                 550                 555                 560 


Val Pro Ala Pro Phe Phe Leu Pro Ala Ser Leu Ser Ala Asn Asn Thr 
                565                 570                 575     


Pro Thr Arg Arg Val Ser Pro Leu Asn Leu Ser Ser Val Thr Pro 
            580                 585                 590     


<210>  1150
<211>  1980
<212>  DNA
<213>  Homosapiens

<400>  1150
ccaggaccct ggtgggagag tgtgtgcgtc gcgctggagg gcgggaggcg ggggcgggag     60

gtgccggtcg agggagcccc gctctcagag ctccagggga ggagcgaggg gagcgcggag    120

cccggcgcct acagctcgcc atggtgcgcc ccctgaaccc gcgaccgctg ccgcccgtag    180

tcctgatgtt gctgctgctg ctgccgccgt cgccgctgcc tctcgcagcc ggagaccccc    240

ttcccacaga aagccgactc atgaacagct gtctccaggc caggaggaag tgccaggctg    300

atcccacctg cagtgctgcc taccaccacc tggattcctg cacctctagc ataagcaccc    360

cactgccctc agaggagcct tcggtccctg ctgactgcct ggaggcagca cagcaactca    420

ggaacagctc tctgataggc tgcatgtgcc accggcgcat gaagaaccag gttgcctgct    480

tggacatcta ttggaccgtt caccgtgccc gcagccttgg taactatgag ctggatgtct    540

ccccctatga agacacagtg accagcaaac cctggaaaat gaatctcagc aaactgaaca    600

tgctcaaacc agactcagac ctctgcctca agtttgccat gctgtgtact ctcaatgaca    660

agtgtgaccg gctgcgcaag gcctacgggg aggcgtgctc cgggccccac tgccagcgcc    720

acgtctgcct caggcagctg ctcactttct tcgagaaggc cgccgagccc cacgcgcagg    780

gcctgctact gtgcccatgt gcccccaacg accggggctg cggggagcgc cggcgcaaca    840

ccatcgcccc caactgcgcg ctgccgcctg tggcccccaa ctgcctggag ctgcggcgcc    900

tctgcttctc cgacccgctt tgcagatcac gcctggtgga tttccagacc cactgccatc    960

ccatggacat cctaggaact tgtgcaacag agcagtccag atgtctacga gcatacctgg   1020

ggctgattgg gactgccatg acccccaact ttgtcagcaa tgtcaacacc agtgttgcct   1080

taagctgcac ctgccgaggc agtggcaacc tgcaggagga gtgtgaaatg ctggaagggt   1140

tcttctccca caacccctgc ctcacggagg ccattgcagc taagatgcgt tttcacagcc   1200

aactcttctc ccaggactgg ccacacccta cctttgctgt gatggcacac cagaatgaaa   1260

accctgctgt gaggccacag ccctgggtgc cctctctttt ctcctgcacg cttcccttga   1320

ttctgctcct gagcctatgg tagctggact tccccagggc cctcttcccc tccaccacac   1380

ccaggtggac ttgcagccca caaggggtga ggaaaggaca gcagcaggaa ggaggtgcag   1440

tgcgcagatg agggcacagg agaagctaag ggttatgacc tccagatcct tactggtcca   1500

gtcctcattc cctccacccc atctccactt ctgattcatg ctgcccctcc ttggtggcca   1560

caatttagcc atgtcatctg gtggtgacca gctccaccaa gcccctttct gagcccttcc   1620

tcttgactac caggatcacc agaatctaat aagttagcca ttctctattg cattccagat   1680

tagggttagg gtagggagga ctgggtgttc tgaggcagcc tagaaagtca ttctcctttg   1740

tgaagaaggc tcctgccccc tcgtctcctc ctctgagtgg aggatggaaa actactgcct   1800

gcactgccct gtccccggat cctgccgaac atctgggcat caggagctgg agcctgtggg   1860

ccttgcttta ttcctattat tgtcctaaag tctctctggg ctcttggatc atgattaaac   1920

ctttgactta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1980


<210>  1151
<211>  400
<212>  PRT
<213>  Homosapiens

<400>  1151

Met Val Arg Pro Leu Asn Pro Arg Pro Leu Pro Pro Val Val Leu Met 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Pro Ser Pro Leu Pro Leu Ala Ala Gly Asp 
            20                  25                  30          


Pro Leu Pro Thr Glu Ser Arg Leu Met Asn Ser Cys Leu Gln Ala Arg 
        35                  40                  45              


Arg Lys Cys Gln Ala Asp Pro Thr Cys Ser Ala Ala Tyr His His Leu 
    50                  55                  60                  


Asp Ser Cys Thr Ser Ser Ile Ser Thr Pro Leu Pro Ser Glu Glu Pro 
65                  70                  75                  80  


Ser Val Pro Ala Asp Cys Leu Glu Ala Ala Gln Gln Leu Arg Asn Ser 
                85                  90                  95      


Ser Leu Ile Gly Cys Met Cys His Arg Arg Met Lys Asn Gln Val Ala 
            100                 105                 110         


Cys Leu Asp Ile Tyr Trp Thr Val His Arg Ala Arg Ser Leu Gly Asn 
        115                 120                 125             


Tyr Glu Leu Asp Val Ser Pro Tyr Glu Asp Thr Val Thr Ser Lys Pro 
    130                 135                 140                 


Trp Lys Met Asn Leu Ser Lys Leu Asn Met Leu Lys Pro Asp Ser Asp 
145                 150                 155                 160 


Leu Cys Leu Lys Phe Ala Met Leu Cys Thr Leu Asn Asp Lys Cys Asp 
                165                 170                 175     


Arg Leu Arg Lys Ala Tyr Gly Glu Ala Cys Ser Gly Pro His Cys Gln 
            180                 185                 190         


Arg His Val Cys Leu Arg Gln Leu Leu Thr Phe Phe Glu Lys Ala Ala 
        195                 200                 205             


Glu Pro His Ala Gln Gly Leu Leu Leu Cys Pro Cys Ala Pro Asn Asp 
    210                 215                 220                 


Arg Gly Cys Gly Glu Arg Arg Arg Asn Thr Ile Ala Pro Asn Cys Ala 
225                 230                 235                 240 


Leu Pro Pro Val Ala Pro Asn Cys Leu Glu Leu Arg Arg Leu Cys Phe 
                245                 250                 255     


Ser Asp Pro Leu Cys Arg Ser Arg Leu Val Asp Phe Gln Thr His Cys 
            260                 265                 270         


His Pro Met Asp Ile Leu Gly Thr Cys Ala Thr Glu Gln Ser Arg Cys 
        275                 280                 285             


Leu Arg Ala Tyr Leu Gly Leu Ile Gly Thr Ala Met Thr Pro Asn Phe 
    290                 295                 300                 


Val Ser Asn Val Asn Thr Ser Val Ala Leu Ser Cys Thr Cys Arg Gly 
305                 310                 315                 320 


Ser Gly Asn Leu Gln Glu Glu Cys Glu Met Leu Glu Gly Phe Phe Ser 
                325                 330                 335     


His Asn Pro Cys Leu Thr Glu Ala Ile Ala Ala Lys Met Arg Phe His 
            340                 345                 350         


Ser Gln Leu Phe Ser Gln Asp Trp Pro His Pro Thr Phe Ala Val Met 
        355                 360                 365             


Ala His Gln Asn Glu Asn Pro Ala Val Arg Pro Gln Pro Trp Val Pro 
    370                 375                 380                 


Ser Leu Phe Ser Cys Thr Leu Pro Leu Ile Leu Leu Leu Ser Leu Trp 
385                 390                 395                 400 


<210>  1152
<211>  2115
<212>  DNA
<213>  Homosapiens

<400>  1152
ggtcaacgcc tgcggctgtt gatattcttg ctcagaggcc gtaactttgg ccttctgctc     60

agggaagact ctgagtccga cgttggccta cccagtcgga aggcagagct gcaatctagt    120

taactacctc ctttccccta gatttccttt cattctgctc aagtcttcgc ctgtgtccga    180

tccctatcta ctttctctcc tcttgtagca agcctcagac tccaggcttg agctaggttt    240

tgtttttctc ctggtgagaa ttcgaagacc atgtctacgg aactcttctc atccacaaga    300

gaggaaggaa gctctggctc aggacccagt tttaggtcta atcaaaggaa aatgttaaac    360

ctgctcctgg agagagacac ttcctttacc gtctgtccag atgtccctag aactccagtg    420

ggcaaatttc ttggtgattc tgcaaaccta agcattttgt ctggaggaac cccaaaatgt    480

tgcctcgatc tttcgaatct tagcagtggg gagataactg ccactcagct taccacttct    540

gcagaccttg atgaaactgg tcacctggat tcttcaggac ttcaggaagt gcatttagct    600

gggatgaatc atgaccagca cctaatgaaa tgtagcccag cacagcttct ttgtagcact    660

ccgaatggtt tggaccgtgg ccatagaaag agagatgcaa tgtgtagttc atctgcaaat    720

aaagaaaatg acaatggaaa cttggtggac agtgaaatga aatatttggg cagtcccatt    780

actactgttc caaaattgga taaaaatcca aacctaggag aagaccaggc agaagagatt    840

tcagatgaat taatggagtt ttccctgaaa gatcaagaag caaaggtgag cagaagtggc    900

ctatatcgct ccccgtcgat gccagagaac ttgaacaggc caagactgaa gcaggtggaa    960

aaattcaagg acaacacaat accagataaa gttaaaaaaa agtatttttc tggccaagga   1020

aagctcagga agggcttatg tttaaagaag acagtctctc tgtgtgacat tactatcact   1080

cagatgctgg aggaagattc taaccagggg cacctgattg gtgatttttc caaggtatgt   1140

gcgctgccaa ccgtgtcagg gaaacaccaa gatctgaagt atgtcaaccc agaaacagtg   1200

gctgccttac tgtcggggaa gttccagggt ctgattgaga agttttatgt cattgattgt   1260

cgctatccat atgagtatct gggaggacac atccagggag ccttaaactt atatagtcag   1320

gaagaactgt ttaacttctt tctgaagaag cccatcgtcc ctttggacac ccagaagaga   1380

ataatcatcg tgttccactg tgaattctcc tcagagaggg gcccccgaat gtgccgctgt   1440

ctgcgtgaag aggacaggtc tctgaaccag tatcctgcat tgtactaccc agagctatat   1500

atccttaaag gcggctacag agacttcttt ccagaatata tggaactgtg tgaaccacag   1560

agctactgcc ctatgcatca tcaggaccac aagactgagt tgctgaggtg tcgaagccag   1620

agcaaagtgc aggaagggga gcggcagctg cgggagcaga ttgcccttct ggtgaaggac   1680

atgagcccat gataacattc cagccactgg ctgctaacaa gtcaccaaaa agacactgca   1740

gaaaccctga gcagaaagag gccttctgga tggccaaacc caagattatt aaaagatgtc   1800

tctgcaaacc aacaggctac caacttgtat ccaggcctgg gaatggatta ggtttcagca   1860

gagctgaaag ctggtggcag agtcctggag ctggctctat aaggcagcct tgagttgcat   1920

agagatttgt attggttcag ggaactctgg cattcctttt cccaactcct catgtcttct   1980

cacaagccag ccaactcttt ctctctgggc ttcgggctat gcaagagcgt tgtctacctt   2040

ctttctttgt attttccttc tttgtttccc cctctttctt ttttaaaaat ggaaaaataa   2100

acactacaga atgag                                                    2115


<210>  1153
<211>  473
<212>  PRT
<213>  Homosapiens

<400>  1153

Met Ser Thr Glu Leu Phe Ser Ser Thr Arg Glu Glu Gly Ser Ser Gly 
1               5                   10                  15      


Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu 
            20                  25                  30          


Leu Glu Arg Asp Thr Ser Phe Thr Val Cys Pro Asp Val Pro Arg Thr 
        35                  40                  45              


Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser 
    50                  55                  60                  


Gly Gly Thr Pro Lys Cys Cys Leu Asp Leu Ser Asn Leu Ser Ser Gly 
65                  70                  75                  80  


Glu Ile Thr Ala Thr Gln Leu Thr Thr Ser Ala Asp Leu Asp Glu Thr 
                85                  90                  95      


Gly His Leu Asp Ser Ser Gly Leu Gln Glu Val His Leu Ala Gly Met 
            100                 105                 110         


Asn His Asp Gln His Leu Met Lys Cys Ser Pro Ala Gln Leu Leu Cys 
        115                 120                 125             


Ser Thr Pro Asn Gly Leu Asp Arg Gly His Arg Lys Arg Asp Ala Met 
    130                 135                 140                 


Cys Ser Ser Ser Ala Asn Lys Glu Asn Asp Asn Gly Asn Leu Val Asp 
145                 150                 155                 160 


Ser Glu Met Lys Tyr Leu Gly Ser Pro Ile Thr Thr Val Pro Lys Leu 
                165                 170                 175     


Asp Lys Asn Pro Asn Leu Gly Glu Asp Gln Ala Glu Glu Ile Ser Asp 
            180                 185                 190         


Glu Leu Met Glu Phe Ser Leu Lys Asp Gln Glu Ala Lys Val Ser Arg 
        195                 200                 205             


Ser Gly Leu Tyr Arg Ser Pro Ser Met Pro Glu Asn Leu Asn Arg Pro 
    210                 215                 220                 


Arg Leu Lys Gln Val Glu Lys Phe Lys Asp Asn Thr Ile Pro Asp Lys 
225                 230                 235                 240 


Val Lys Lys Lys Tyr Phe Ser Gly Gln Gly Lys Leu Arg Lys Gly Leu 
                245                 250                 255     


Cys Leu Lys Lys Thr Val Ser Leu Cys Asp Ile Thr Ile Thr Gln Met 
            260                 265                 270         


Leu Glu Glu Asp Ser Asn Gln Gly His Leu Ile Gly Asp Phe Ser Lys 
        275                 280                 285             


Val Cys Ala Leu Pro Thr Val Ser Gly Lys His Gln Asp Leu Lys Tyr 
    290                 295                 300                 


Val Asn Pro Glu Thr Val Ala Ala Leu Leu Ser Gly Lys Phe Gln Gly 
305                 310                 315                 320 


Leu Ile Glu Lys Phe Tyr Val Ile Asp Cys Arg Tyr Pro Tyr Glu Tyr 
                325                 330                 335     


Leu Gly Gly His Ile Gln Gly Ala Leu Asn Leu Tyr Ser Gln Glu Glu 
            340                 345                 350         


Leu Phe Asn Phe Phe Leu Lys Lys Pro Ile Val Pro Leu Asp Thr Gln 
        355                 360                 365             


Lys Arg Ile Ile Ile Val Phe His Cys Glu Phe Ser Ser Glu Arg Gly 
    370                 375                 380                 


Pro Arg Met Cys Arg Cys Leu Arg Glu Glu Asp Arg Ser Leu Asn Gln 
385                 390                 395                 400 


Tyr Pro Ala Leu Tyr Tyr Pro Glu Leu Tyr Ile Leu Lys Gly Gly Tyr 
                405                 410                 415     


Arg Asp Phe Phe Pro Glu Tyr Met Glu Leu Cys Glu Pro Gln Ser Tyr 
            420                 425                 430         


Cys Pro Met His His Gln Asp His Lys Thr Glu Leu Leu Arg Cys Arg 
        435                 440                 445             


Ser Gln Ser Lys Val Gln Glu Gly Glu Arg Gln Leu Arg Glu Gln Ile 
    450                 455                 460                 


Ala Leu Leu Val Lys Asp Met Ser Pro 
465                 470             


<210>  1154
<211>  1896
<212>  DNA
<213>  Homosapiens

<400>  1154
ggtcaacgcc tgcggctgtt gatattcttg ctcagaggcc gtaactttgg ccttctgctc     60

agggaagact ctgagtccga cgttggccta cccagtcgga aggcagagct gcaatctagt    120

taactacctc ctttccccta gatttccttt cattctgctc aagtcttcgc ctgtgtccga    180

tccctatcta ctttctctcc tcttgtagca agcctcagac tccaggcttg agctaggttt    240

tgtttttctc ctggtgagaa ttcgaagacc atgtctacgg aactcttctc atccacaaga    300

gaggaaggaa gctctggctc aggacccagt tttaggtcta atcaaaggaa aatgttaaac    360

ctgctcctgg agagagacac ttcctttacc gtctgtccag atgtccctag aactccagtg    420

ggcaaatttc ttggtgattc tgcaaaccta agcattttgt ctgggtcacc tggattcttc    480

aggacttcag gaagtgcatt tagctgggat gacaatggaa acttggtgga cagtgaaatg    540

aaatatttgg gcagtcccat tactactgtt ccaaaattgg ataaaaatcc aaacctagga    600

gaagaccagg cagaagagat ttcagatgaa ttaatggagt tttccctgaa agatcaagaa    660

gcaaaggtga gcagaagtgg cctatatcgc tccccgtcga tgccagagaa cttgaacagg    720

ccaagactga agcaggtgga aaaattcaag gacaacacaa taccagataa agttaaaaaa    780

aagtattttt ctggccaagg aaagctcagg aagggcttat gtttaaagaa gacagtctct    840

ctgtgtgaca ttactatcac tcagatgctg gaggaagatt ctaaccaggg gcacctgatt    900

ggtgattttt ccaaggtatg tgcgctgcca accgtgtcag ggaaacacca agatctgaag    960

tatgtcaacc cagaaacagt ggctgcctta ctgtcgggga agttccaggg tctgattgag   1020

aagttttatg tcattgattg tcgctatcca tatgagtatc tgggaggaca catccaggga   1080

gccttaaact tatatagtca ggaagaactg tttaacttct ttctgaagaa gcccatcgtc   1140

cctttggaca cccagaagag aataatcatc gtgttccact gtgaattctc ctcagagagg   1200

ggcccccgaa tgtgccgctg tctgcgtgaa gaggacaggt ctctgaacca gtatcctgca   1260

ttgtactacc cagagctata tatccttaaa ggcggctaca gagacttctt tccagaatat   1320

atggaactgt gtgaaccaca gagctactgc cctatgcatc atcaggacca caagactgag   1380

ttgctgaggt gtcgaagcca gagcaaagtg caggaagggg agcggcagct gcgggagcag   1440

attgcccttc tggtgaagga catgagccca tgataacatt ccagccactg gctgctaaca   1500

agtcaccaaa aagacactgc agaaaccctg agcagaaaga ggccttctgg atggccaaac   1560

ccaagattat taaaagatgt ctctgcaaac caacaggcta ccaacttgta tccaggcctg   1620

ggaatggatt aggtttcagc agagctgaaa gctggtggca gagtcctgga gctggctcta   1680

taaggcagcc ttgagttgca tagagatttg tattggttca gggaactctg gcattccttt   1740

tcccaactcc tcatgtcttc tcacaagcca gccaactctt tctctctggg cttcgggcta   1800

tgcaagagcg ttgtctacct tctttctttg tattttcctt ctttgtttcc ccctctttct   1860

tttttaaaaa tggaaaaata aacactacag aatgag                             1896


<210>  1155
<211>  400
<212>  PRT
<213>  Homosapiens

<400>  1155

Met Ser Thr Glu Leu Phe Ser Ser Thr Arg Glu Glu Gly Ser Ser Gly 
1               5                   10                  15      


Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu 
            20                  25                  30          


Leu Glu Arg Asp Thr Ser Phe Thr Val Cys Pro Asp Val Pro Arg Thr 
        35                  40                  45              


Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser 
    50                  55                  60                  


Gly Ser Pro Gly Phe Phe Arg Thr Ser Gly Ser Ala Phe Ser Trp Asp 
65                  70                  75                  80  


Asp Asn Gly Asn Leu Val Asp Ser Glu Met Lys Tyr Leu Gly Ser Pro 
                85                  90                  95      


Ile Thr Thr Val Pro Lys Leu Asp Lys Asn Pro Asn Leu Gly Glu Asp 
            100                 105                 110         


Gln Ala Glu Glu Ile Ser Asp Glu Leu Met Glu Phe Ser Leu Lys Asp 
        115                 120                 125             


Gln Glu Ala Lys Val Ser Arg Ser Gly Leu Tyr Arg Ser Pro Ser Met 
    130                 135                 140                 


Pro Glu Asn Leu Asn Arg Pro Arg Leu Lys Gln Val Glu Lys Phe Lys 
145                 150                 155                 160 


Asp Asn Thr Ile Pro Asp Lys Val Lys Lys Lys Tyr Phe Ser Gly Gln 
                165                 170                 175     


Gly Lys Leu Arg Lys Gly Leu Cys Leu Lys Lys Thr Val Ser Leu Cys 
            180                 185                 190         


Asp Ile Thr Ile Thr Gln Met Leu Glu Glu Asp Ser Asn Gln Gly His 
        195                 200                 205             


Leu Ile Gly Asp Phe Ser Lys Val Cys Ala Leu Pro Thr Val Ser Gly 
    210                 215                 220                 


Lys His Gln Asp Leu Lys Tyr Val Asn Pro Glu Thr Val Ala Ala Leu 
225                 230                 235                 240 


Leu Ser Gly Lys Phe Gln Gly Leu Ile Glu Lys Phe Tyr Val Ile Asp 
                245                 250                 255     


Cys Arg Tyr Pro Tyr Glu Tyr Leu Gly Gly His Ile Gln Gly Ala Leu 
            260                 265                 270         


Asn Leu Tyr Ser Gln Glu Glu Leu Phe Asn Phe Phe Leu Lys Lys Pro 
        275                 280                 285             


Ile Val Pro Leu Asp Thr Gln Lys Arg Ile Ile Ile Val Phe His Cys 
    290                 295                 300                 


Glu Phe Ser Ser Glu Arg Gly Pro Arg Met Cys Arg Cys Leu Arg Glu 
305                 310                 315                 320 


Glu Asp Arg Ser Leu Asn Gln Tyr Pro Ala Leu Tyr Tyr Pro Glu Leu 
                325                 330                 335     


Tyr Ile Leu Lys Gly Gly Tyr Arg Asp Phe Phe Pro Glu Tyr Met Glu 
            340                 345                 350         


Leu Cys Glu Pro Gln Ser Tyr Cys Pro Met His His Gln Asp His Lys 
        355                 360                 365             


Thr Glu Leu Leu Arg Cys Arg Ser Gln Ser Lys Val Gln Glu Gly Glu 
    370                 375                 380                 


Arg Gln Leu Arg Glu Gln Ile Ala Leu Leu Val Lys Asp Met Ser Pro 
385                 390                 395                 400 


<210>  1156
<211>  4135
<212>  DNA
<213>  Homosapiens

<400>  1156
ccgcggccct gggagctgga ggaaccgcga ctcagcaggc atgactggag agggaagtcc     60

caatggtgct agaatggtgc tgcagtggca gaagacggct cacaagtgag gtctggaaga    120

acaacaggga agacatccat catttgctcc aaagtgtgca agtcaaatcc tggggagaat    180

catgataacc ctgatcactg agcagctaca gaagcagact ctggatgagc tgaaatgcac    240

acgcttcagc atcagtctgc ctttgcctga tcatgcagac atctccaact gtgggaactc    300

tttccagctt gtgtctgaag gtgcttcctg gaggggcctg ccccactgtt cctgtgctga    360

gttccaggac agcctcaact tcagctacca tccctcaggc ctgagcctgc acctcagacc    420

acccagtcgg ggaaactccc ccaaggagca gcccttctcc caagtcctaa gacctgagcc    480

cccagatcca gagaagcttc ctgtgccccc tgcccctcca tccaagaggc actgccgctc    540

actctcagtg cccgtggacc tgtctcgctg gcagccggtg tggcggcccg ccccctccaa    600

gctgtggact cccataaagc accggggcag tggtggaggg ggtgggccgc aggtgcctca    660

ccagagcccc ccaaagcggg tctccagcct caggttcctc caagctccca gtgcctcttc    720

tcaatgtgcc ccagctcaca gaccctacag ccctcctttc ttcagcctgg ccctggccca    780

agattcctct cgaccctgcg ccgcctcccc tcaaagtggc tcctgggaga gtgatgctga    840

gtccttgtca ccttgcccac ctcagcgccg cttctccctg tcacccagtc tgggcccgca    900

ggcaagccgc ttcttgccct ctgcccggag ctctcccgca tcctccccag agctgccctg    960

gcgacctcga ggtctccgca accttccccg aagccgctca cagccttgtg atctggatgc   1020

ccgcaaaact ggggtcaagc ggcgccacga ggaagacccc cggcgtctgc ggccttcgtt   1080

ggactttgac aagatgaatc agaaaccata ctcaggaggt ctttgtctcc aagaaacagc   1140

ccgggaaggc agcagcatct ctccaccatg gttcatggcc tgtagccccc cacccctctc   1200

tgcttcctgc agccccactg ggggttcctc ccaggtgctg agtgaaagcg aagaggagga   1260

ggagggggct gtgcggtggg gtcggcaggc gctgagcaag cggacactgt gccagcggga   1320

ctttggggac ctggacttga atttgattga ggaaaactaa aactgagagg ctacttcctg   1380

gggccacaca gactgactct ctcatggcta ctaacaagtg tcgagtcccc aaggctgggg   1440

gccgagcctg ggaatggggg tgagtggagg gctccgactc agggcagctg gaaatcttct   1500

cgctccagca agctcgacca tgccaagaga ctggccggga caagataaac ggagctggtg   1560

gcgggaggga cagccccaga gcagaccctt cctatggcgg ccctgagtgt gagtatccct   1620

gccaccaaga gagcaatggg cagggaagga aggggtctgc cgaccccagc tcggggaatt   1680

tcactagccc ctttgcttca aagggcactt gtgtcttaga atttggccag ggtggggggt   1740

tgagtcagcc tcctcagaga aactgcgtga gagtgtgtgc gtgcatggga gtgtacttgt   1800

ggaaaggtgt gtttgcgtag ccttagggaa ggaaggcaat tgctccttaa cagcagagta   1860

tcatgatacc cccaggatct tgagtttttt acaggatgtt gggtttgctc aaggagtcaa   1920

gaggagggca ccaagttttc cttttttcta aatagctctg gaaccaggct tgtaatccat   1980

agcatcaccg actctgcaaa ggatttcatt ttggggtaca gcagggtgtt ttaagtgctg   2040

tgacttcagc taatgatctt ttcttcagcc ccaccccctc cccactagct cgatctagta   2100

tattggggaa tgcaggtggg gggtgtcacc atattttttc tgagctggcc tttttttctc   2160

atcagattgt ccaggctata ttccacctgc ctcttttgcc ctcttgagta gagttgcaca   2220

cagcacatgg gcaactgaag cagggttgag gggctctatc tctctctctc ctctgctgat   2280

gggacccttt tcccctcacc ctctgccctt ctaagtcata gactaggtag gaaggcccta   2340

tattggtccc cagcatctac tgaggcagac ctgcaacaga agtggcattc agtccccagc   2400

agacatgggt gagctcaccc cagcactgct gttgggaagg tgactgcagg aaaccaattc   2460

ttacaagatc caggcccagc ctttttgacc tgcttgagag ggaagaaggg gtgtttagca   2520

tttaatagtt tgcttgtctt ccactcctgc caggaagtgt ttatttgcct ctaattgggc   2580

ctgagagacc atagggaggt tggggctcac tgagggattg gctgaggatg tataaagcaa   2640

aggctgtgag aagcagttgg gagtttggtt gtcattggat tgaatttact tttttgtttc   2700

tcacccgcaa cttgagccag gacagctggt ccaagtggcc acagtgatgg gtttaagtac   2760

cttggtaggg ctggcaccag tggaaacaca tactgaagct gccaccacaa tagcttgtga   2820

ggttttatcc agctttggtt agaccctgca tgaccaaatt tgacctgccc ttgtttatgg   2880

caagaagggc atttttctct tcaatttcca gggtttccta ggacccagtt cctcatgtaa   2940

gggaggaaga ccaaggtctt tgtgttttct tcctcatgga attgaacctg acattttctg   3000

gatctcctgc atgtcaggag catcagtgag gcttcagcct ccttgtctcc actccagaga   3060

ggaggtggct atgtcttctt aagcctctgg ccctcagagg ctcctcccta tctcctggct   3120

agttaccact aggctaccag gtctctaggg gcctgagaga ggccctctag agaatccagg   3180

gaaactgtga gcccaggagt tgcccatcta tggtttcatt cctcccctgg ctcttctccc   3240

tcttcaggcc ataatttccc tggtgccaat ttcttttcct cctggggcat cctcatccca   3300

gggctctctg ctgtagattg gctgtgccag cttccaacag gttactggca atgccagtga   3360

gtttctgtag gccctaagct gaagaagtga ggcagtgatt ctgcctccat cctggtttcc   3420

ccaaagcccc agggcaccat ccttaaggga gaaggtctac agttatcatt attttaattc   3480

cattactttc agtctggaaa actaagctag tcagaactgt catcttgctt cccaatctaa   3540

gaacctgtgg ccctggaaca cttttcaaga attggttcat tttgctttac acagtagatc   3600

tgttccaaca gttctgtgta aaccaaatgc tatttttcaa tgcatttgga ctgctgacca   3660

tttaaaagca gcctatgatt gcttcttttt gtaaagcaag caacctccct ccactttagc   3720

tgttttgact atttgaattt tcacatattg ggcttaccca gagtggagca cacctccagg   3780

gcatgtggct gacactgggt caatgtctgc atctgtgctg tgtgtgtagt gtggttggcc   3840

agtaggtgag tatccctgtg tgtgtgagtg aagccactcc ccaggctggt gctctcctcc   3900

tgtgcccagt gactgcccag tggcagctca gctgcccttc actcccacct gctgccaaag   3960

tccctgtgct aatgggatta caaatacaaa aagtggaaaa aaattttcgt aaactttgtt   4020

ttatattaaa agaaaaatcc ataagtctgt gtgtgttaaa catgaggttc tgcctctgtg   4080

gctgtgtttg aaaaaataaa gttttattag aataatccat tttcccaagc aaaaa        4135


<210>  1157
<211>  392
<212>  PRT
<213>  Homosapiens

<400>  1157

Met Ile Thr Leu Ile Thr Glu Gln Leu Gln Lys Gln Thr Leu Asp Glu 
1               5                   10                  15      


Leu Lys Cys Thr Arg Phe Ser Ile Ser Leu Pro Leu Pro Asp His Ala 
            20                  25                  30          


Asp Ile Ser Asn Cys Gly Asn Ser Phe Gln Leu Val Ser Glu Gly Ala 
        35                  40                  45              


Ser Trp Arg Gly Leu Pro His Cys Ser Cys Ala Glu Phe Gln Asp Ser 
    50                  55                  60                  


Leu Asn Phe Ser Tyr His Pro Ser Gly Leu Ser Leu His Leu Arg Pro 
65                  70                  75                  80  


Pro Ser Arg Gly Asn Ser Pro Lys Glu Gln Pro Phe Ser Gln Val Leu 
                85                  90                  95      


Arg Pro Glu Pro Pro Asp Pro Glu Lys Leu Pro Val Pro Pro Ala Pro 
            100                 105                 110         


Pro Ser Lys Arg His Cys Arg Ser Leu Ser Val Pro Val Asp Leu Ser 
        115                 120                 125             


Arg Trp Gln Pro Val Trp Arg Pro Ala Pro Ser Lys Leu Trp Thr Pro 
    130                 135                 140                 


Ile Lys His Arg Gly Ser Gly Gly Gly Gly Gly Pro Gln Val Pro His 
145                 150                 155                 160 


Gln Ser Pro Pro Lys Arg Val Ser Ser Leu Arg Phe Leu Gln Ala Pro 
                165                 170                 175     


Ser Ala Ser Ser Gln Cys Ala Pro Ala His Arg Pro Tyr Ser Pro Pro 
            180                 185                 190         


Phe Phe Ser Leu Ala Leu Ala Gln Asp Ser Ser Arg Pro Cys Ala Ala 
        195                 200                 205             


Ser Pro Gln Ser Gly Ser Trp Glu Ser Asp Ala Glu Ser Leu Ser Pro 
    210                 215                 220                 


Cys Pro Pro Gln Arg Arg Phe Ser Leu Ser Pro Ser Leu Gly Pro Gln 
225                 230                 235                 240 


Ala Ser Arg Phe Leu Pro Ser Ala Arg Ser Ser Pro Ala Ser Ser Pro 
                245                 250                 255     


Glu Leu Pro Trp Arg Pro Arg Gly Leu Arg Asn Leu Pro Arg Ser Arg 
            260                 265                 270         


Ser Gln Pro Cys Asp Leu Asp Ala Arg Lys Thr Gly Val Lys Arg Arg 
        275                 280                 285             


His Glu Glu Asp Pro Arg Arg Leu Arg Pro Ser Leu Asp Phe Asp Lys 
    290                 295                 300                 


Met Asn Gln Lys Pro Tyr Ser Gly Gly Leu Cys Leu Gln Glu Thr Ala 
305                 310                 315                 320 


Arg Glu Gly Ser Ser Ile Ser Pro Pro Trp Phe Met Ala Cys Ser Pro 
                325                 330                 335     


Pro Pro Leu Ser Ala Ser Cys Ser Pro Thr Gly Gly Ser Ser Gln Val 
            340                 345                 350         


Leu Ser Glu Ser Glu Glu Glu Glu Glu Gly Ala Val Arg Trp Gly Arg 
        355                 360                 365             


Gln Ala Leu Ser Lys Arg Thr Leu Cys Gln Arg Asp Phe Gly Asp Leu 
    370                 375                 380                 


Asp Leu Asn Leu Ile Glu Glu Asn 
385                 390         


<210>  1158
<211>  6830
<212>  DNA
<213>  Homosapiens

<400>  1158
gcggggccca ggctgcggct ccgctcccgg ccacgggggg cgctgcgctg cgccggtggt     60

tggtggtggc tgttgggggg ggtggggggg aacggcggcc gcgggtggtg cggagggagg    120

ccttgcgggc ggatcgggcg cttggcggcg gaggtggtgg gaggcggcgg gcgggagcgc    180

gggtcaggcc ggccccggcg atggcggacg cggcggcctc cccggtgggc aagcggctgc    240

tgctgctgtt cgcggacact gcggcctcag cctcggcctc ggctcccgcg gcggcagcgg    300

cgagcggaga tccggggcct gcgctgcgca ctcgagcctg gcgggccggc acggtgcggg    360

ccatgagcgg ggcggtgccc caggacctag cgatctttgt agaatttgat ggctgtaact    420

ggaagcaaca ctcctgggta aaagttcatg ctgaggaagt tatcgtgctt ctgctggaag    480

ggtctcttgt atgggcgccc cgtgaggacc cagtccttct ccagggcatt cgagtctcca    540

ttgcacaatg gccagccctg acttttactc cccttgtaga taaactgggt ttgggttctg    600

tggttccagt ggaatatctt ctggatcgag agcttcggtt cctgtcagat gccaatgggt    660

tgcatctgtt tcagatggga acagatagcc aaaaccagat tcttttggaa catgctgcac    720

tgagagaaac agttaatgct ttgatcagtg accaaaagct acaagagata ttcagccgag    780

gtccctacag tgttcaaggt cacagggtca aaatatatca gccagagggg gaagaagggt    840

ggctctatgg tgttgtgagc catcaggact ccatcactcg tcttatggag gtgtctgtaa    900

ctgagagtgg tgagatcaag tcggtagatc ccagactaat ccatgtgatg ctgatggata    960

attcaacgcc tcaaagcgag gggggtacgt taaaagcagt aaaatcttcc aaaggaaaga   1020

agaagagaga aagcatagag gggaaagatg gccggaggag gaaaagtgct tcggactctg   1080

ggtgtgaccc tgcatcaaag aaattaaaag gagacagggg tgaagtagac agtaatggga   1140

gcgatggagg tgaggcaagc cgagggccct ggaaaggagg gaatgccagt ggagagccag   1200

ggctggatca gagagccaag cagccaccgt ctacatttgt cccccagata aaccgcaaca   1260

ttcgctttgc cacttacacc aaagaaaacg gcaggactct ggtggtgcag gatgagcctg   1320

taggtgggga cacacctgca tctttcactc catattctac agccacaggt cagacacctt   1380

tggccccaga ggtgggtgga gccgaaaaca aagaggcagg aaaaacactg gaacaagttg   1440

gccagggcat agtggcttcc gcagctgtgg tcactaccgc cagctccacc ccaaacacag   1500

tgaggatctc agacactggc cttgcagcag ggactgtgcc agaaaaacag aaaggcagcc   1560

ggtcgcaggc ctcgggagag aattcaagaa attctattct ggcctcttct ggatttggag   1620

cacctctccc tagttcatcg caacctttga cttttggaag tggaaggagc cagtccaatg   1680

gtgttctagc cacagagaac aaacctttgg gcttctcttt tggctgtagc tctgcacaag   1740

aggcacagaa agacactgat ctctccaaaa acttgttttt tcaatgcatg tcccaaactt   1800

tacctaccag taactacttc actactgttt cagagagttt ggctgatgat tcttctagtc   1860

gggactcatt caaacaaagc cttgagagcc tgagctcagg cctgtgtaaa ggcagatccg   1920

ttcttggaac agacactaag ccaggctcta aggctggcag ctctgtggac cggaaagtgc   1980

ctgcagagtc catgcccacc ctcactccag ccttcccacg gagcctccta aatgcccgta   2040

ccccagagaa tcatgaaaat ctatttttac agccccccaa attgtcccga gaagagcctt   2100

ctaatccttt cctggcattt gtggagaaag ttgaacacag ccctttcagt agttttgcat   2160

ctcaggcatc aggtagctcc tcttctgcta ccactgtcac ctccaaggtg gcacccagct   2220

ggcccgagtc tcactcctct gcagattcgg catctttagc aaagaagaaa cccctcttca   2280

ttacaactga ctcctccaag ctagtatctg gtgttctggg ctcagctctt accagtgggg   2340

gcccaagcct ctctgccatg gggaatggcc gctccagctc gcccaccagc agcctcactc   2400

agcccattga gatgccaact ctctcctcta gccccacaga ggagaggcca actgtggggc   2460

ctgggcagca ggacaatccc ctcctcaaaa cctttagtaa cgtctttggc aggcactcag   2520

gcggctttct gtcctccccg gcagattttt cacaggagaa caaagctcct tttgaagctg   2580

tgaaaaggtt ctcactggat gaacgaagct tggcttgcag acaagactcg gactccagca   2640

ccaacagtga cctgtcagat ttgagtgact ctgaggagca gctgcaggct aagacaggcc   2700

tgaagggaat tccagagcac ctgatgggga agctgggccc caatggggag cgcagtgctg   2760

agctgttgct gggcaaaagc aaagggaagc aggcccccaa gggccggcct cggactgccc   2820

ccctgaaagt tggccagtca gtgctgaaag atgtaagcaa agtgaagaag ctgaagcaat   2880

ctggagagcc cttcctgcag gatgggtcat gcatcaatgt ggcacctcat ctgcacaagt   2940

gtcgtgaatg ccgcctggag cggtaccgga agtttaagga acaggagcaa gatgattcta   3000

ctgtagcctg ccgtttcttt cacttccgga ggttgatctt cactcgaaaa ggggtactcc   3060

gtgtggaggg gtttttaagc ccccagcaaa gtgaccctga tgccatgaac ctgtggattc   3120

cctcttcctc cctagcagaa gggatagatc tagagacctc aaaatacatc ctggccaatg   3180

ttggggacca gttctgccag ctcgtaatgt ctgagaagga ggccatgatg atggtggagc   3240

cacaccagaa agtggcatgg aagcgagctg tgcgtggtgt acgggagatg tgtgatgtgt   3300

gtgaaacaac tctcttcaac atccactggg tttgtcgcaa atgtggattt ggggtctgcc   3360

ttgactgtta ccggctcagg aaaagccggc cacgcagtga gacagaagag atgggtgatg   3420

aagaagtttt ctcctggttg aagtgtgcaa agggacagtc ccacgaacca gagaatctca   3480

tgcccacaca aattattcct ggcacagctc tttacaatat tggagacatg gtacatgctg   3540

cccggggcaa gtggggaatt aaagcaaact gcccttgtat cagtcgacag aacaaatctg   3600

tattgagacc tgccgtcacc aatgggatgt cacagcttcc tagcataaac cctagtgcct   3660

cttctggaaa cgaaactacc ttctctggtg gaggaggacc ggcaccagta acaactccag   3720

agccggacca tgttcccaaa gccgacagca ctgacatcag atctgaagag cctctgaaaa   3780

cagacagttc ggcatcaaat agcaatagtg aactgaaagc catcaggcct ccttgccctg   3840

acacggcccc accctcctcc gccctgcact ggttggcaga tttagcaact cagaaggcta   3900

aagaagaaac aaaagaagca gggtccctga ggtcggtgct caataaagag tctcattcac   3960

cctttgggct ggactcgttc aactccactg caaaggtctc tccgctgact ccaaagcttt   4020

ttaacagtct gttgctgggt cccactgcct ccaacaacaa aaccgaaggg tctagccttc   4080

gagacctcct tcactccggg ccgggaaaac ttcctcaaac ccccttggac acaggcatac   4140

cctttccccc ggtcttctct acatcctcag caggagtgaa gagcaaggcc agcctaccca   4200

actttcttga ccacatcatt gcctcagtgg tagaaaataa gaaaacctca gatgcttcaa   4260

agcgggcctg caacttgact gatacccaga aggaagtgaa ggagatggtg atggggttaa   4320

atgtgctaga tccccatact tctcactcct ggctttgtga tgggaggctt ctgtgtctcc   4380

atgaccccag caacaaaaac aattggaaga tcttccggga gtgttggaag caaggtcagc   4440

cagtgctggt ttcgggggta cataaaaagc tcaagtctga gctctggaag ccagaagcct   4500

ttagccagga atttggagac caggatgtag acttggtgaa ctgcaggaac tgtgctataa   4560

tttccgatgt gaaagttcgg gatttctggg atggtttcga gatcatatgc aaacgactac   4620

ggtcagaaga tgggcagcca atggtgctca aactcaagga ctggcctcct ggggaagatt   4680

ttcgagacat gatgccaacc aggtttgaag atctgatgga gaaccttcct ctgccagaat   4740

ataccaaacg agatggcagg ctcaatctgg cctctaggct acctagctac tttgtaaggc   4800

ctgatctggg ccccaagatg tacaacgcct atgggttgat aacagcagaa gatagaagag   4860

ttggtacaac aaatcttcac ttagatgtgt ctgatgctgt taatgtgatg gtgtatgttg   4920

ggattcccat cggggagggt gctcatgatg aagaggtact caagacaatt gacgagggag   4980

atgccgatga ggtgacgaag cagaggattc atgatggaaa agagaagcca ggtgctttat   5040

ggcacatcta tgcagccaag gatgcagaga agatccggga gctgctccga aaggttggag   5100

aagaacaagg ccaagagaac ccccctgatc atgacccaat tcatgaccaa agttggtacc   5160

tggaccagac cctccgtaag cgactctatg aggagtatgg cgtgcaaggc tgggctattg   5220

tgcagttcct aggtgatgct gttttcatac ctgctggagc cccacaccag gttcacaatc   5280

tatacagttg cataaaagta gcagaagact ttgtatctcc agaacatgta aagcactgtt   5340

tccgcctgac tcaggaattc aggcatctct ctaacactca tacaaatcat gaggataaac   5400

tgcaggtgaa gaacatcatt taccatgcag tgaaagatgc ggttggcacc ctcaaggctc   5460

atgaatccaa actggcaagg tcctaggcat ggagaaactc caagctcctc tgtgaagcag   5520

gtctttcact cacaacactt aacagggaac ggcagggctc tttgctggag cagaggccct   5580

tcacccagag ccagtgtggt cagtattcca aactctccag ccactctctt ctacgctgcc   5640

tcaacactga aggttgacac aggaaagtcg tactgttcac acacacagtt tgagactcca   5700

agccaagagt gccacatccc tatcctgtgg ccttttggaa atccaaattg cctgaacatg   5760

gcggggcttt cctgcacatt ctcctgattt gagattcacg ggcacacctt tcttttcttt   5820

tcctcttgtg cctagttaag tggaaatgtg tttggagata ggggaaatca cataactggt   5880

acaagtatgg ggtaattgct taaacatgcc tggtggaagt ctgatagcgt ctctgcacgt   5940

gacctctgac aaagcccatc ccaggagacg gggtgaagct attccccaca ctctcctgtg   6000

aacactggag tcttgcaaga cccagggaga acccactgct tttcccagga ggctccagga   6060

ttaggaaatg tgtgtattta gtgaaaaata ggtttgtagt gaaatagtta ctatttcatg   6120

aaagtagata tttttagaat ttttgaaata ccacagttgt tttcctggat tataaggaaa   6180

ggcacattac atttagtctt cctttcgata taaaactctt tgaagaaata tgatttttag   6240

aaatcagcta cccattatag cacaaaatca gccaaagcag aatttttaaa aattggcttt   6300

tttaggattc tttttctccc cctcccatct tagtcttacc ttgagggaac agtcatatga   6360

gaaggaactt tgtcacatct aagctgtggt gtgttcccca tgtgtgtgta caacactggt   6420

gactccagga accattttca cctattacca gtgttccctg gggactcctc ttaatgtttc   6480

caaatgggaa ggacagttga tttccaacat gaggtttttt gttttttatc cagaaatatt   6540

ttcagcaaaa ctttccaact gagtggagtc tgattaagga tttatttgaa aatggtggga   6600

ttcattggcc cataggtaca ttggaaaatg tatatctctc cagctgtact gtagtgccct   6660

gcaggctgtt tatatgttca cagttacttt tttttttttt tttaaataaa agtcatttaa   6720

tgtagaatac ttttaatttc actttctgta ttttaatttt gttgaagggc tgattgggat   6780

ttccatgttc ttattaaaaa tctaacaaat ctgaaaaaaa aaaaaaaaaa              6830


<210>  1159
<211>  1761
<212>  PRT
<213>  Homosapiens

<400>  1159

Met Ala Asp Ala Ala Ala Ser Pro Val Gly Lys Arg Leu Leu Leu Leu 
1               5                   10                  15      


Phe Ala Asp Thr Ala Ala Ser Ala Ser Ala Ser Ala Pro Ala Ala Ala 
            20                  25                  30          


Ala Ala Ser Gly Asp Pro Gly Pro Ala Leu Arg Thr Arg Ala Trp Arg 
        35                  40                  45              


Ala Gly Thr Val Arg Ala Met Ser Gly Ala Val Pro Gln Asp Leu Ala 
    50                  55                  60                  


Ile Phe Val Glu Phe Asp Gly Cys Asn Trp Lys Gln His Ser Trp Val 
65                  70                  75                  80  


Lys Val His Ala Glu Glu Val Ile Val Leu Leu Leu Glu Gly Ser Leu 
                85                  90                  95      


Val Trp Ala Pro Arg Glu Asp Pro Val Leu Leu Gln Gly Ile Arg Val 
            100                 105                 110         


Ser Ile Ala Gln Trp Pro Ala Leu Thr Phe Thr Pro Leu Val Asp Lys 
        115                 120                 125             


Leu Gly Leu Gly Ser Val Val Pro Val Glu Tyr Leu Leu Asp Arg Glu 
    130                 135                 140                 


Leu Arg Phe Leu Ser Asp Ala Asn Gly Leu His Leu Phe Gln Met Gly 
145                 150                 155                 160 


Thr Asp Ser Gln Asn Gln Ile Leu Leu Glu His Ala Ala Leu Arg Glu 
                165                 170                 175     


Thr Val Asn Ala Leu Ile Ser Asp Gln Lys Leu Gln Glu Ile Phe Ser 
            180                 185                 190         


Arg Gly Pro Tyr Ser Val Gln Gly His Arg Val Lys Ile Tyr Gln Pro 
        195                 200                 205             


Glu Gly Glu Glu Gly Trp Leu Tyr Gly Val Val Ser His Gln Asp Ser 
    210                 215                 220                 


Ile Thr Arg Leu Met Glu Val Ser Val Thr Glu Ser Gly Glu Ile Lys 
225                 230                 235                 240 


Ser Val Asp Pro Arg Leu Ile His Val Met Leu Met Asp Asn Ser Thr 
                245                 250                 255     


Pro Gln Ser Glu Gly Gly Thr Leu Lys Ala Val Lys Ser Ser Lys Gly 
            260                 265                 270         


Lys Lys Lys Arg Glu Ser Ile Glu Gly Lys Asp Gly Arg Arg Arg Lys 
        275                 280                 285             


Ser Ala Ser Asp Ser Gly Cys Asp Pro Ala Ser Lys Lys Leu Lys Gly 
    290                 295                 300                 


Asp Arg Gly Glu Val Asp Ser Asn Gly Ser Asp Gly Gly Glu Ala Ser 
305                 310                 315                 320 


Arg Gly Pro Trp Lys Gly Gly Asn Ala Ser Gly Glu Pro Gly Leu Asp 
                325                 330                 335     


Gln Arg Ala Lys Gln Pro Pro Ser Thr Phe Val Pro Gln Ile Asn Arg 
            340                 345                 350         


Asn Ile Arg Phe Ala Thr Tyr Thr Lys Glu Asn Gly Arg Thr Leu Val 
        355                 360                 365             


Val Gln Asp Glu Pro Val Gly Gly Asp Thr Pro Ala Ser Phe Thr Pro 
    370                 375                 380                 


Tyr Ser Thr Ala Thr Gly Gln Thr Pro Leu Ala Pro Glu Val Gly Gly 
385                 390                 395                 400 


Ala Glu Asn Lys Glu Ala Gly Lys Thr Leu Glu Gln Val Gly Gln Gly 
                405                 410                 415     


Ile Val Ala Ser Ala Ala Val Val Thr Thr Ala Ser Ser Thr Pro Asn 
            420                 425                 430         


Thr Val Arg Ile Ser Asp Thr Gly Leu Ala Ala Gly Thr Val Pro Glu 
        435                 440                 445             


Lys Gln Lys Gly Ser Arg Ser Gln Ala Ser Gly Glu Asn Ser Arg Asn 
    450                 455                 460                 


Ser Ile Leu Ala Ser Ser Gly Phe Gly Ala Pro Leu Pro Ser Ser Ser 
465                 470                 475                 480 


Gln Pro Leu Thr Phe Gly Ser Gly Arg Ser Gln Ser Asn Gly Val Leu 
                485                 490                 495     


Ala Thr Glu Asn Lys Pro Leu Gly Phe Ser Phe Gly Cys Ser Ser Ala 
            500                 505                 510         


Gln Glu Ala Gln Lys Asp Thr Asp Leu Ser Lys Asn Leu Phe Phe Gln 
        515                 520                 525             


Cys Met Ser Gln Thr Leu Pro Thr Ser Asn Tyr Phe Thr Thr Val Ser 
    530                 535                 540                 


Glu Ser Leu Ala Asp Asp Ser Ser Ser Arg Asp Ser Phe Lys Gln Ser 
545                 550                 555                 560 


Leu Glu Ser Leu Ser Ser Gly Leu Cys Lys Gly Arg Ser Val Leu Gly 
                565                 570                 575     


Thr Asp Thr Lys Pro Gly Ser Lys Ala Gly Ser Ser Val Asp Arg Lys 
            580                 585                 590         


Val Pro Ala Glu Ser Met Pro Thr Leu Thr Pro Ala Phe Pro Arg Ser 
        595                 600                 605             


Leu Leu Asn Ala Arg Thr Pro Glu Asn His Glu Asn Leu Phe Leu Gln 
    610                 615                 620                 


Pro Pro Lys Leu Ser Arg Glu Glu Pro Ser Asn Pro Phe Leu Ala Phe 
625                 630                 635                 640 


Val Glu Lys Val Glu His Ser Pro Phe Ser Ser Phe Ala Ser Gln Ala 
                645                 650                 655     


Ser Gly Ser Ser Ser Ser Ala Thr Thr Val Thr Ser Lys Val Ala Pro 
            660                 665                 670         


Ser Trp Pro Glu Ser His Ser Ser Ala Asp Ser Ala Ser Leu Ala Lys 
        675                 680                 685             


Lys Lys Pro Leu Phe Ile Thr Thr Asp Ser Ser Lys Leu Val Ser Gly 
    690                 695                 700                 


Val Leu Gly Ser Ala Leu Thr Ser Gly Gly Pro Ser Leu Ser Ala Met 
705                 710                 715                 720 


Gly Asn Gly Arg Ser Ser Ser Pro Thr Ser Ser Leu Thr Gln Pro Ile 
                725                 730                 735     


Glu Met Pro Thr Leu Ser Ser Ser Pro Thr Glu Glu Arg Pro Thr Val 
            740                 745                 750         


Gly Pro Gly Gln Gln Asp Asn Pro Leu Leu Lys Thr Phe Ser Asn Val 
        755                 760                 765             


Phe Gly Arg His Ser Gly Gly Phe Leu Ser Ser Pro Ala Asp Phe Ser 
    770                 775                 780                 


Gln Glu Asn Lys Ala Pro Phe Glu Ala Val Lys Arg Phe Ser Leu Asp 
785                 790                 795                 800 


Glu Arg Ser Leu Ala Cys Arg Gln Asp Ser Asp Ser Ser Thr Asn Ser 
                805                 810                 815     


Asp Leu Ser Asp Leu Ser Asp Ser Glu Glu Gln Leu Gln Ala Lys Thr 
            820                 825                 830         


Gly Leu Lys Gly Ile Pro Glu His Leu Met Gly Lys Leu Gly Pro Asn 
        835                 840                 845             


Gly Glu Arg Ser Ala Glu Leu Leu Leu Gly Lys Ser Lys Gly Lys Gln 
    850                 855                 860                 


Ala Pro Lys Gly Arg Pro Arg Thr Ala Pro Leu Lys Val Gly Gln Ser 
865                 870                 875                 880 


Val Leu Lys Asp Val Ser Lys Val Lys Lys Leu Lys Gln Ser Gly Glu 
                885                 890                 895     


Pro Phe Leu Gln Asp Gly Ser Cys Ile Asn Val Ala Pro His Leu His 
            900                 905                 910         


Lys Cys Arg Glu Cys Arg Leu Glu Arg Tyr Arg Lys Phe Lys Glu Gln 
        915                 920                 925             


Glu Gln Asp Asp Ser Thr Val Ala Cys Arg Phe Phe His Phe Arg Arg 
    930                 935                 940                 


Leu Ile Phe Thr Arg Lys Gly Val Leu Arg Val Glu Gly Phe Leu Ser 
945                 950                 955                 960 


Pro Gln Gln Ser Asp Pro Asp Ala Met Asn Leu Trp Ile Pro Ser Ser 
                965                 970                 975     


Ser Leu Ala Glu Gly Ile Asp Leu Glu Thr Ser Lys Tyr Ile Leu Ala 
            980                 985                 990         


Asn Val Gly Asp Gln Phe Cys Gln  Leu Val Met Ser Glu  Lys Glu Ala 
        995                 1000                 1005             


Met Met  Met Val Glu Pro His  Gln Lys Val Ala Trp  Lys Arg Ala 
    1010                 1015                 1020             


Val Arg  Gly Val Arg Glu Met  Cys Asp Val Cys Glu  Thr Thr Leu 
    1025                 1030                 1035             


Phe Asn  Ile His Trp Val Cys  Arg Lys Cys Gly Phe  Gly Val Cys 
    1040                 1045                 1050             


Leu Asp  Cys Tyr Arg Leu Arg  Lys Ser Arg Pro Arg  Ser Glu Thr 
    1055                 1060                 1065             


Glu Glu  Met Gly Asp Glu Glu  Val Phe Ser Trp Leu  Lys Cys Ala 
    1070                 1075                 1080             


Lys Gly  Gln Ser His Glu Pro  Glu Asn Leu Met Pro  Thr Gln Ile 
    1085                 1090                 1095             


Ile Pro  Gly Thr Ala Leu Tyr  Asn Ile Gly Asp Met  Val His Ala 
    1100                 1105                 1110             


Ala Arg  Gly Lys Trp Gly Ile  Lys Ala Asn Cys Pro  Cys Ile Ser 
    1115                 1120                 1125             


Arg Gln  Asn Lys Ser Val Leu  Arg Pro Ala Val Thr  Asn Gly Met 
    1130                 1135                 1140             


Ser Gln  Leu Pro Ser Ile Asn  Pro Ser Ala Ser Ser  Gly Asn Glu 
    1145                 1150                 1155             


Thr Thr  Phe Ser Gly Gly Gly  Gly Pro Ala Pro Val  Thr Thr Pro 
    1160                 1165                 1170             


Glu Pro  Asp His Val Pro Lys  Ala Asp Ser Thr Asp  Ile Arg Ser 
    1175                 1180                 1185             


Glu Glu  Pro Leu Lys Thr Asp  Ser Ser Ala Ser Asn  Ser Asn Ser 
    1190                 1195                 1200             


Glu Leu  Lys Ala Ile Arg Pro  Pro Cys Pro Asp Thr  Ala Pro Pro 
    1205                 1210                 1215             


Ser Ser  Ala Leu His Trp Leu  Ala Asp Leu Ala Thr  Gln Lys Ala 
    1220                 1225                 1230             


Lys Glu  Glu Thr Lys Glu Ala  Gly Ser Leu Arg Ser  Val Leu Asn 
    1235                 1240                 1245             


Lys Glu  Ser His Ser Pro Phe  Gly Leu Asp Ser Phe  Asn Ser Thr 
    1250                 1255                 1260             


Ala Lys  Val Ser Pro Leu Thr  Pro Lys Leu Phe Asn  Ser Leu Leu 
    1265                 1270                 1275             


Leu Gly  Pro Thr Ala Ser Asn  Asn Lys Thr Glu Gly  Ser Ser Leu 
    1280                 1285                 1290             


Arg Asp  Leu Leu His Ser Gly  Pro Gly Lys Leu Pro  Gln Thr Pro 
    1295                 1300                 1305             


Leu Asp  Thr Gly Ile Pro Phe  Pro Pro Val Phe Ser  Thr Ser Ser 
    1310                 1315                 1320             


Ala Gly  Val Lys Ser Lys Ala  Ser Leu Pro Asn Phe  Leu Asp His 
    1325                 1330                 1335             


Ile Ile  Ala Ser Val Val Glu  Asn Lys Lys Thr Ser  Asp Ala Ser 
    1340                 1345                 1350             


Lys Arg  Ala Cys Asn Leu Thr  Asp Thr Gln Lys Glu  Val Lys Glu 
    1355                 1360                 1365             


Met Val  Met Gly Leu Asn Val  Leu Asp Pro His Thr  Ser His Ser 
    1370                 1375                 1380             


Trp Leu  Cys Asp Gly Arg Leu  Leu Cys Leu His Asp  Pro Ser Asn 
    1385                 1390                 1395             


Lys Asn  Asn Trp Lys Ile Phe  Arg Glu Cys Trp Lys  Gln Gly Gln 
    1400                 1405                 1410             


Pro Val  Leu Val Ser Gly Val  His Lys Lys Leu Lys  Ser Glu Leu 
    1415                 1420                 1425             


Trp Lys  Pro Glu Ala Phe Ser  Gln Glu Phe Gly Asp  Gln Asp Val 
    1430                 1435                 1440             


Asp Leu  Val Asn Cys Arg Asn  Cys Ala Ile Ile Ser  Asp Val Lys 
    1445                 1450                 1455             


Val Arg  Asp Phe Trp Asp Gly  Phe Glu Ile Ile Cys  Lys Arg Leu 
    1460                 1465                 1470             


Arg Ser  Glu Asp Gly Gln Pro  Met Val Leu Lys Leu  Lys Asp Trp 
    1475                 1480                 1485             


Pro Pro  Gly Glu Asp Phe Arg  Asp Met Met Pro Thr  Arg Phe Glu 
    1490                 1495                 1500             


Asp Leu  Met Glu Asn Leu Pro  Leu Pro Glu Tyr Thr  Lys Arg Asp 
    1505                 1510                 1515             


Gly Arg  Leu Asn Leu Ala Ser  Arg Leu Pro Ser Tyr  Phe Val Arg 
    1520                 1525                 1530             


Pro Asp  Leu Gly Pro Lys Met  Tyr Asn Ala Tyr Gly  Leu Ile Thr 
    1535                 1540                 1545             


Ala Glu  Asp Arg Arg Val Gly  Thr Thr Asn Leu His  Leu Asp Val 
    1550                 1555                 1560             


Ser Asp  Ala Val Asn Val Met  Val Tyr Val Gly Ile  Pro Ile Gly 
    1565                 1570                 1575             


Glu Gly  Ala His Asp Glu Glu  Val Leu Lys Thr Ile  Asp Glu Gly 
    1580                 1585                 1590             


Asp Ala  Asp Glu Val Thr Lys  Gln Arg Ile His Asp  Gly Lys Glu 
    1595                 1600                 1605             


Lys Pro  Gly Ala Leu Trp His  Ile Tyr Ala Ala Lys  Asp Ala Glu 
    1610                 1615                 1620             


Lys Ile  Arg Glu Leu Leu Arg  Lys Val Gly Glu Glu  Gln Gly Gln 
    1625                 1630                 1635             


Glu Asn  Pro Pro Asp His Asp  Pro Ile His Asp Gln  Ser Trp Tyr 
    1640                 1645                 1650             


Leu Asp  Gln Thr Leu Arg Lys  Arg Leu Tyr Glu Glu  Tyr Gly Val 
    1655                 1660                 1665             


Gln Gly  Trp Ala Ile Val Gln  Phe Leu Gly Asp Ala  Val Phe Ile 
    1670                 1675                 1680             


Pro Ala  Gly Ala Pro His Gln  Val His Asn Leu Tyr  Ser Cys Ile 
    1685                 1690                 1695             


Lys Val  Ala Glu Asp Phe Val  Ser Pro Glu His Val  Lys His Cys 
    1700                 1705                 1710             


Phe Arg  Leu Thr Gln Glu Phe  Arg His Leu Ser Asn  Thr His Thr 
    1715                 1720                 1725             


Asn His  Glu Asp Lys Leu Gln  Val Lys Asn Ile Ile  Tyr His Ala 
    1730                 1735                 1740             


Val Lys  Asp Ala Val Gly Thr  Leu Lys Ala His Glu  Ser Lys Leu 
    1745                 1750                 1755             


Ala Arg  Ser 
    1760     


<210>  1160
<211>  2117
<212>  DNA
<213>  Homosapiens

<400>  1160
gctgctgcag cggctgctgc tgctactgcg gctcctgctg ccgccgccgc cgccgctcgg     60

cctcaggcag ctgcatcctc ggccgggccg ggtccccgcc ccgcgccgcg cccggccccg    120

ccatggtgtc ctggatcatc tctcgcctgg tggtgctcat ctttggcacc ctgtacccag    180

cctattcttc ctacaaggcc gtgaagacaa aaaacgtgaa ggaatatgtg aaatggatga    240

tgtactggat cgtctttgcc ttcttcacca cggccgagac gctcacggat atagtgctct    300

cctggttccc cttctacttt gaactgaaga tcgccttcgt gatatggctg ctgtcccctt    360

acaccaaggg ctccagcgtg ctctaccgca agttcgtgca cccaacgctg tccaacaagg    420

agaaggagat cgacgagtac atcacgcagg cccgagacaa gagctatgag accatgatga    480

gggtgggcaa gaggggcctg aaccttgccg ccaatgctgc agtcacagct gccgccaagg    540

gggtgctgtc agagaagctc cgcagcttca gcatgcagga cctgaccctg atccgggacg    600

aggacgcact gcccctgcag aggcctgacg gccgcctccg acccagccct ggcagcctcc    660

tggacaccat cgaggactta ggagatgacc ctgccctgag tctaaggtcc agcacaaacc    720

cggcagattc ccggacagag gcttctgagg atgacatggg agacaaagct cccaagaggg    780

ccaaacccat caaaaaagcg cccaaagctg agccactggc ttccaagaca ctgaagaccc    840

ggcccaagaa gaagacctct ggcgggggcg actcagcttg agcccctcca cccccgcagg    900

ctgcagagca aggatgaagc ctcaggaggg gcctcagacc cagcccctgc tccacactgt    960

gccagtagcc taggtgtctc aggcccctgg gccccgcaga tggccatttc cggtgcctgc   1020

ccagtggcca ctcttctgga aggggcttgg aaaagaggaa ggaggcccag ctgtgggggt   1080

tgagggtaga gggtggacca gaggctgagg actgagccac ccaaggaggt ggggactgct   1140

cggcctccac cgctgttccg ctgcagcccc gccctgcccc acccacccag tgccttgctg   1200

aagcccatag caatccgctt ctcagaggtc ctatcgtgtt tccactgctc gccttggttt   1260

gggagcaggg agggggaagt cctagcccag atggaccaag gacgggcctg aaggcacatg   1320

ggggaaaggg agcacacggg gaggacgttg gggaccctgg gtggggcctc caggtgcagc   1380

tgtggatgga agacagggat tggcctgtgc ttcagcgacc aggatggcca ggccagagct   1440

gcagctgggg gctcttttcc tggtcattgg gtggggctga gtgccacatg ttcccacatt   1500

aaaaaggggg gtccagggct gtgtgagtgt gtctttctgg gtctagggct cggggtagtt   1560

tgggtcaagg actgtccctc cagcagtcgc ctcctcccac cctgagcccc acagtcatct   1620

ggccctttcc ctgctcaacc ctccatccta ggctctgagc ctcagaggac ccagcccatg   1680

agagaacggg gatctggggg gcctctcacc tgctcctatg accttgctcc cttttaggtc   1740

accccattgc caccgtgccc ctgggctgga ctcccatgct cctcagggcc cacccctgct   1800

ctgtctggta caggcccctg ctgagtgggc ccctctcctc tgcccctggg gtccatcccc   1860

tcttgcccag ggtccccatc ctgtaccaag cagactgggc cctaagaccc ctggcagaac   1920

ccagcctctg ctcacacccg ccccagcttc tgccacggct tcagtcaggg ccaggaggaa   1980

cacgtgaagg agaaagagaa atgcaggagc cgcggggctc ccggttcctt gggaagaggg   2040

tgcccattgg acctttggca ctggatgagc caataaacca aactctggca cctcatttaa   2100

aaaaaaaaaa aaaaaaa                                                  2117


<210>  1161
<211>  252
<212>  PRT
<213>  Homosapiens

<400>  1161

Met Val Ser Trp Ile Ile Ser Arg Leu Val Val Leu Ile Phe Gly Thr 
1               5                   10                  15      


Leu Tyr Pro Ala Tyr Ser Ser Tyr Lys Ala Val Lys Thr Lys Asn Val 
            20                  25                  30          


Lys Glu Tyr Val Lys Trp Met Met Tyr Trp Ile Val Phe Ala Phe Phe 
        35                  40                  45              


Thr Thr Ala Glu Thr Leu Thr Asp Ile Val Leu Ser Trp Phe Pro Phe 
    50                  55                  60                  


Tyr Phe Glu Leu Lys Ile Ala Phe Val Ile Trp Leu Leu Ser Pro Tyr 
65                  70                  75                  80  


Thr Lys Gly Ser Ser Val Leu Tyr Arg Lys Phe Val His Pro Thr Leu 
                85                  90                  95      


Ser Asn Lys Glu Lys Glu Ile Asp Glu Tyr Ile Thr Gln Ala Arg Asp 
            100                 105                 110         


Lys Ser Tyr Glu Thr Met Met Arg Val Gly Lys Arg Gly Leu Asn Leu 
        115                 120                 125             


Ala Ala Asn Ala Ala Val Thr Ala Ala Ala Lys Gly Val Leu Ser Glu 
    130                 135                 140                 


Lys Leu Arg Ser Phe Ser Met Gln Asp Leu Thr Leu Ile Arg Asp Glu 
145                 150                 155                 160 


Asp Ala Leu Pro Leu Gln Arg Pro Asp Gly Arg Leu Arg Pro Ser Pro 
                165                 170                 175     


Gly Ser Leu Leu Asp Thr Ile Glu Asp Leu Gly Asp Asp Pro Ala Leu 
            180                 185                 190         


Ser Leu Arg Ser Ser Thr Asn Pro Ala Asp Ser Arg Thr Glu Ala Ser 
        195                 200                 205             


Glu Asp Asp Met Gly Asp Lys Ala Pro Lys Arg Ala Lys Pro Ile Lys 
    210                 215                 220                 


Lys Ala Pro Lys Ala Glu Pro Leu Ala Ser Lys Thr Leu Lys Thr Arg 
225                 230                 235                 240 


Pro Lys Lys Lys Thr Ser Gly Gly Gly Asp Ser Ala 
                245                 250         


<210>  1162
<211>  3136
<212>  DNA
<213>  Homosapiens

<400>  1162
gcgcagaact tggggagccg ccgccgccat ccgccgccgc agccagcttc cgccgccgca     60

ggaccggccc ctgccccagc ctccgcagcc gcggcgcgtc cacgcccgcc cgcgcccagg    120

gcgagtcggg gtcgccgcct gcacgcttct cagtgttccc cgcgccccgc atgtaacccg    180

gccaggcccc cgcaactgtg tcccctgcag ctccagcccc gggctgcacc cccccgcccc    240

gacaccagct ctccagcctg ctcgtccagg atggccgcgg ccaaggccga gatgcagctg    300

atgtccccgc tgcagatctc tgacccgttc ggatcctttc ctcactcgcc caccatggac    360

aactacccta agctggagga gatgatgctg ctgagcaacg gggctcccca gttcctcggc    420

gccgccgggg ccccagaggg cagcggcagc aacagcagca gcagcagcag cgggggcggt    480

ggaggcggcg ggggcggcag caacagcagc agcagcagca gcaccttcaa ccctcaggcg    540

gacacgggcg agcagcccta cgagcacctg accgcagagt cttttcctga catctctctg    600

aacaacgaga aggtgctggt ggagaccagt taccccagcc aaaccactcg actgcccccc    660

atcacctata ctggccgctt ttccctggag cctgcaccca acagtggcaa caccttgtgg    720

cccgagcccc tcttcagctt ggtcagtggc ctagtgagca tgaccaaccc accggcctcc    780

tcgtcctcag caccatctcc agcggcctcc tccgcctccg cctcccagag cccacccctg    840

agctgcgcag tgccatccaa cgacagcagt cccatttact cagcggcacc caccttcccc    900

acgccgaaca ctgacatttt ccctgagcca caaagccagg ccttcccggg ctcggcaggg    960

acagcgctcc agtacccgcc tcctgcctac cctgccgcca agggtggctt ccaggttccc   1020

atgatccccg actacctgtt tccacagcag cagggggatc tgggcctggg caccccagac   1080

cagaagccct tccagggcct ggagagccgc acccagcagc cttcgctaac ccctctgtct   1140

actattaagg cctttgccac tcagtcgggc tcccaggacc tgaaggccct caataccagc   1200

taccagtccc agctcatcaa acccagccgc atgcgcaagt accccaaccg gcccagcaag   1260

acgccccccc acgaacgccc ttacgcttgc ccagtggagt cctgtgatcg ccgcttctcc   1320

cgctccgacg agctcacccg ccacatccgc atccacacag gccagaagcc cttccagtgc   1380

cgcatctgca tgcgcaactt cagccgcagc gaccacctca ccacccacat ccgcacccac   1440

acaggcgaaa agcccttcgc ctgcgacatc tgtggaagaa agtttgccag gagcgatgaa   1500

cgcaagaggc ataccaagat ccacttgcgg cagaaggaca agaaagcaga caaaagtgtt   1560

gtggcctctt cggccacctc ctctctctct tcctacccgt ccccggttgc tacctcttac   1620

ccgtccccgg ttactacctc ttatccatcc ccggccacca cctcataccc atcccctgtg   1680

cccacctcct tctcctctcc cggctcctcg acctacccat cccctgtgca cagtggcttc   1740

ccctccccgt cggtggccac cacgtactcc tctgttcccc ctgctttccc ggcccaggtc   1800

agcagcttcc cttcctcagc tgtcaccaac tccttcagcg cctccacagg gctttcggac   1860

atgacagcaa ccttttctcc caggacaatt gaaatttgct aaagggaaag gggaaagaaa   1920

gggaaaaggg agaaaaagaa acacaagaga cttaaaggac aggaggagga gatggccata   1980

ggagaggagg gttcctctta ggtcagatgg aggttctcag agccaagtcc tccctctcta   2040

ctggagtgga aggtctattg gccaacaatc ctttctgccc acttcccctt ccccaattac   2100

tattcccttt gacttcagct gcctgaaaca gccatgtcca agttcttcac ctctatccaa   2160

agaacttgat ttgcatggat tttggataaa tcatttcagt atcatctcca tcatatgcct   2220

gaccccttgc tcccttcaat gctagaaaat cgagttggca aaatggggtt tgggcccctc   2280

agagccctgc cctgcaccct tgtacagtgt ctgtgccatg gatttcgttt ttcttggggt   2340

actcttgatg tgaagataat ttgcatattc tattgtatta tttggagtta ggtcctcact   2400

tgggggaaaa aaaaaaaaga aaagccaagc aaaccaatgg tgatcctcta ttttgtgatg   2460

atgctgtgac aataagtttg aacctttttt tttgaaacag cagtcccagt attctcagag   2520

catgtgtcag agtgttgttc cgttaacctt tttgtaaata ctgcttgacc gtactctcac   2580

atgtggcaaa atatggtttg gtttttcttt tttttttttt ttgaaagtgt tttttcttcg   2640

tccttttggt ttaaaaagtt tcacgtcttg gtgccttttg tgtgatgcgc cttgctgatg   2700

gcttgacatg tgcaattgtg agggacatgc tcacctctag ccttaagggg ggcagggagt   2760

gatgatttgg gggaggcttt gggagcaaaa taaggaagag ggctgagctg agcttcggtt   2820

ctccagaatg taagaaaaca aaatctaaaa caaaatctga actctcaaaa gtctattttt   2880

ttaactgaaa atgtaaattt ataaatatat tcaggagttg gaatgttgta gttacctact   2940

gagtaggcgg cgatttttgt atgttatgaa catgcagttc attattttgt ggttctattt   3000

tactttgtac ttgtgtttgc ttaaacaaag tgactgtttg gcttataaac acattgaatg   3060

cgctttattg cccatgggat atgtggtgta tatccttcca aaaaattaaa acgaaaataa   3120

agtagctgcg attggg                                                   3136


<210>  1163
<211>  543
<212>  PRT
<213>  Homosapiens

<400>  1163

Met Ala Ala Ala Lys Ala Glu Met Gln Leu Met Ser Pro Leu Gln Ile 
1               5                   10                  15      


Ser Asp Pro Phe Gly Ser Phe Pro His Ser Pro Thr Met Asp Asn Tyr 
            20                  25                  30          


Pro Lys Leu Glu Glu Met Met Leu Leu Ser Asn Gly Ala Pro Gln Phe 
        35                  40                  45              


Leu Gly Ala Ala Gly Ala Pro Glu Gly Ser Gly Ser Asn Ser Ser Ser 
    50                  55                  60                  


Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Asn Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Thr Phe Asn Pro Gln Ala Asp Thr Gly Glu Gln Pro 
                85                  90                  95      


Tyr Glu His Leu Thr Ala Glu Ser Phe Pro Asp Ile Ser Leu Asn Asn 
            100                 105                 110         


Glu Lys Val Leu Val Glu Thr Ser Tyr Pro Ser Gln Thr Thr Arg Leu 
        115                 120                 125             


Pro Pro Ile Thr Tyr Thr Gly Arg Phe Ser Leu Glu Pro Ala Pro Asn 
    130                 135                 140                 


Ser Gly Asn Thr Leu Trp Pro Glu Pro Leu Phe Ser Leu Val Ser Gly 
145                 150                 155                 160 


Leu Val Ser Met Thr Asn Pro Pro Ala Ser Ser Ser Ser Ala Pro Ser 
                165                 170                 175     


Pro Ala Ala Ser Ser Ala Ser Ala Ser Gln Ser Pro Pro Leu Ser Cys 
            180                 185                 190         


Ala Val Pro Ser Asn Asp Ser Ser Pro Ile Tyr Ser Ala Ala Pro Thr 
        195                 200                 205             


Phe Pro Thr Pro Asn Thr Asp Ile Phe Pro Glu Pro Gln Ser Gln Ala 
    210                 215                 220                 


Phe Pro Gly Ser Ala Gly Thr Ala Leu Gln Tyr Pro Pro Pro Ala Tyr 
225                 230                 235                 240 


Pro Ala Ala Lys Gly Gly Phe Gln Val Pro Met Ile Pro Asp Tyr Leu 
                245                 250                 255     


Phe Pro Gln Gln Gln Gly Asp Leu Gly Leu Gly Thr Pro Asp Gln Lys 
            260                 265                 270         


Pro Phe Gln Gly Leu Glu Ser Arg Thr Gln Gln Pro Ser Leu Thr Pro 
        275                 280                 285             


Leu Ser Thr Ile Lys Ala Phe Ala Thr Gln Ser Gly Ser Gln Asp Leu 
    290                 295                 300                 


Lys Ala Leu Asn Thr Ser Tyr Gln Ser Gln Leu Ile Lys Pro Ser Arg 
305                 310                 315                 320 


Met Arg Lys Tyr Pro Asn Arg Pro Ser Lys Thr Pro Pro His Glu Arg 
                325                 330                 335     


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            340                 345                 350         


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        355                 360                 365             


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    370                 375                 380                 


Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile 
385                 390                 395                 400 


Cys Gly Arg Lys Phe Ala Arg Ser Asp Glu Arg Lys Arg His Thr Lys 
                405                 410                 415     


Ile His Leu Arg Gln Lys Asp Lys Lys Ala Asp Lys Ser Val Val Ala 
            420                 425                 430         


Ser Ser Ala Thr Ser Ser Leu Ser Ser Tyr Pro Ser Pro Val Ala Thr 
        435                 440                 445             


Ser Tyr Pro Ser Pro Val Thr Thr Ser Tyr Pro Ser Pro Ala Thr Thr 
    450                 455                 460                 


Ser Tyr Pro Ser Pro Val Pro Thr Ser Phe Ser Ser Pro Gly Ser Ser 
465                 470                 475                 480 


Thr Tyr Pro Ser Pro Val His Ser Gly Phe Pro Ser Pro Ser Val Ala 
                485                 490                 495     


Thr Thr Tyr Ser Ser Val Pro Pro Ala Phe Pro Ala Gln Val Ser Ser 
            500                 505                 510         


Phe Pro Ser Ser Ala Val Thr Asn Ser Phe Ser Ala Ser Thr Gly Leu 
        515                 520                 525             


Ser Asp Met Thr Ala Thr Phe Ser Pro Arg Thr Ile Glu Ile Cys 
    530                 535                 540             


<210>  1164
<211>  3653
<212>  DNA
<213>  Homosapiens

<400>  1164
attgcaacac atgcagctgc ctggagagag ggagccggtg tcctacgtca gagccgccgc     60

cgccgcgagc cgccgccggg gaggagcagc cgctgccgcc caggactggg cccttaggga    120

ggaggaggcg agaagatggc ggacgacccc agtgctgccg acaggaacgt ggagatctgg    180

aagatcaaga agctcattaa gagcttggag gcggcccgcg gcaatggcac cagcatgata    240

tcattgatca ttcctcccaa agaccagatt tcacgagtgg caaaaatgtt agcggatgag    300

tttggaactg catctaacat taagtcacga gtaaaccgcc tttcagtcct gggagccatt    360

acatctgtac aacaaagact caaactttat aacaaagtac ctccaaatgg tctggttgta    420

tactgtggaa caattgtaac agaagaagga aaggaaaaga aagtcaacat tgactttgaa    480

cctttcaaac caattaatac gtcattgtat ttgtgtgaca acaaattcca tacagaggct    540

cttacagcac tactttcaga tgatagcaag tttggattca ttgtaataga tggtagtggt    600

gcactttttg gcacactcca aggaaacaca agagaagtcc tgcacaaatt cactgtggat    660

ctcccaaaga aacacggtag aggaggtcag tcagccttgc gttttgcccg tttaagaatg    720

gaaaagcgac ataactatgt tcggaaagta gcagagactg ctgtgcagct gtttatttct    780

ggggacaaag tgaatgtggc tggtctagtt ttagctggat ccgctgactt taaaactgaa    840

ctaagtcaat ctgatatgtt tgatcagagg ttacaatcaa aagttttaaa attagttgat    900

atatcctatg gtggtgaaaa tggattcaac caagctattg agttatctac tgaagtcctc    960

tccaacgtga aattcattca agagaagaaa ttaataggac gatactttga tgaaatcagc   1020

caggacacgg gcaagtactg ttttggcgtt gaagatacac taaaggcttt ggaaatggga   1080

gctgtagaaa ttctaatagt ctatgaaaat ctggatataa tgagatatgt tcttcattgc   1140

caaggcacag aagaggagaa aattctctat ctaactccag agcaagaaaa ggataaatct   1200

catttcacag acaaagagac cggacaggaa catgagctta tcgagagcat gcccctgttg   1260

gaatggtttg ctaacaacta taaaaaattt ggagctacgt tggaaattgt cacagataaa   1320

tcacaagaag ggtctcagtt tgtgaaagga tttggtggaa ttggaggtat cttgcggtac   1380

cgagtagatt tccagggaat ggaataccaa ggaggagacg atgaattttt tgaccttgat   1440

gactactagg tagtcgacat gggtccggca aaacgtgcct caccctccag catccaaccc   1500

aaggagcata cccatggtgg aatccaaaca gatccctgcc ttacaattgg aacatttcca   1560

gaacttaatc catgagcatt ggatattgaa aagaaaaccg aaacaaaacc agacccagcc   1620

ctacactttg gtttgtcatg gtgtcagcgc agcagcctac aactaagttc ctaaacgcca   1680

ctttggacta atttaaaaaa gaatcccagt ttttactttt actggatggt gaaattggtt   1740

gctcttgtat tttatgaaaa aaaatgattt ttttaacctt catacataga agcaaaaata   1800

ctttaactgc tgtaaacctt caaaagttaa tagaagtgag atcatactgg tttgtttctt   1860

attttgattg gagaaaaatt aaattgctgc atttcgcagt gacccattta catggcattc   1920

tcagcttaga ctgcgtaaga agaaatatat gtggtgaaat gttggaacca tttctctctt   1980

ggtctctgtt taatgttgaa agggtgagct aataggaggc actttcaact tcactccctc   2040

acgctacccc gtccccctcc agactggcag tttcaaggat gcaaattgca ttgcaaaatc   2100

aaactgactc atgaagcatt tgggccagtg cactgtttac ttccatctgt ttgcagacac   2160

atttgtgccc ggcgtttggg agccctttgt atcaatgttc tgacaagggt ccctataacc   2220

ttaacctact cgaaaccggt ttgggatgga tatgatgggg cttctgtgct attgctggga   2280

ttgggagaaa taaaacatgc aatttaagtg gaagcgaaga aatttaaaga ggattttatt   2340

ttgcttgggt caatccttgt taaaagggag gtggatgtgt ttccttgtgt tggatggcat   2400

gagattatgt gaatgttttg atttattaaa atgaactgca aggtttttca caggaacgac   2460

agacatgtat gactgcatgt aattataaac tcctgacctc ctggtggggt tggagcatct   2520

gtttcaaatg tgggacttac aagcacttct cacatgagaa attaggggcg ggtgggaagg   2580

gatgggacac agcttctggc accatggatt taagaccatg ttggatccaa aagttggcct   2640

gaaaccctga agctgatgct tcacagctgg gctgtaagtc agacttgaac ccagctgata   2700

tgcaaggtca tggcgtgcca gggtggtgac agttgaacaa agtgtatagt acgtgcccag   2760

tggtagcgat ggaaaaaagt ataccaaatg gactttgaag gaccaaaggt tttaaaagtc   2820

aattggtatc acctccacac tgactagggt agtggggtgc atttggtttt caaattgggt   2880

acttttaaca ctttagtgcc tgactgctgt tctttactga cttgattcag tcactcgtag   2940

ctttattggt ctgaaccagc tccttgttcc caggttacag acctgcctat cgttccaata   3000

atcctgtttc acttgaatga agggagtatg tcttaaatgt aaagtttctg gttctcacac   3060

tgtactctga ggtccaaata ctgtctgtca atgtgtaacc tgatgtctca accccctgtg   3120

agaagagtcc attatttggt gttcaccaac gtgggagact tcaccggaac aggctttttt   3180

gctttgggct ctgctatttg tttgcagaac acccaagagc gagcaaacac gctctcttca   3240

cagcagtacc ttagggtttt gccattgtaa atgggtctga tgtgatatga caagaccaga   3300

gaaattggat gtaaatttac atttttgaat atgcttgttg tttcacatga tacatttagg   3360

gtatgcagct ccttttgtag tttttatttt tactatttaa gtttggaaat gatgccaaat   3420

ttttgtattt ctttaatcaa tgtgttctct tcggtgatat atattgcatt atatattgat   3480

gtgtgtatca atatatattg atatgtatta cacttacaca tacaaacaca tataagaggg   3540

ggtgaaaacc gtagcctttg cattctctat agcctctgca gagagatact aagcagcaaa   3600

atcttggtgt tgtgatgtac agaaatggag aagagtatta aaccatattt aag          3653


<210>  1165
<211>  437
<212>  PRT
<213>  Homosapiens

<400>  1165

Met Ala Asp Asp Pro Ser Ala Ala Asp Arg Asn Val Glu Ile Trp Lys 
1               5                   10                  15      


Ile Lys Lys Leu Ile Lys Ser Leu Glu Ala Ala Arg Gly Asn Gly Thr 
            20                  25                  30          


Ser Met Ile Ser Leu Ile Ile Pro Pro Lys Asp Gln Ile Ser Arg Val 
        35                  40                  45              


Ala Lys Met Leu Ala Asp Glu Phe Gly Thr Ala Ser Asn Ile Lys Ser 
    50                  55                  60                  


Arg Val Asn Arg Leu Ser Val Leu Gly Ala Ile Thr Ser Val Gln Gln 
65                  70                  75                  80  


Arg Leu Lys Leu Tyr Asn Lys Val Pro Pro Asn Gly Leu Val Val Tyr 
                85                  90                  95      


Cys Gly Thr Ile Val Thr Glu Glu Gly Lys Glu Lys Lys Val Asn Ile 
            100                 105                 110         


Asp Phe Glu Pro Phe Lys Pro Ile Asn Thr Ser Leu Tyr Leu Cys Asp 
        115                 120                 125             


Asn Lys Phe His Thr Glu Ala Leu Thr Ala Leu Leu Ser Asp Asp Ser 
    130                 135                 140                 


Lys Phe Gly Phe Ile Val Ile Asp Gly Ser Gly Ala Leu Phe Gly Thr 
145                 150                 155                 160 


Leu Gln Gly Asn Thr Arg Glu Val Leu His Lys Phe Thr Val Asp Leu 
                165                 170                 175     


Pro Lys Lys His Gly Arg Gly Gly Gln Ser Ala Leu Arg Phe Ala Arg 
            180                 185                 190         


Leu Arg Met Glu Lys Arg His Asn Tyr Val Arg Lys Val Ala Glu Thr 
        195                 200                 205             


Ala Val Gln Leu Phe Ile Ser Gly Asp Lys Val Asn Val Ala Gly Leu 
    210                 215                 220                 


Val Leu Ala Gly Ser Ala Asp Phe Lys Thr Glu Leu Ser Gln Ser Asp 
225                 230                 235                 240 


Met Phe Asp Gln Arg Leu Gln Ser Lys Val Leu Lys Leu Val Asp Ile 
                245                 250                 255     


Ser Tyr Gly Gly Glu Asn Gly Phe Asn Gln Ala Ile Glu Leu Ser Thr 
            260                 265                 270         


Glu Val Leu Ser Asn Val Lys Phe Ile Gln Glu Lys Lys Leu Ile Gly 
        275                 280                 285             


Arg Tyr Phe Asp Glu Ile Ser Gln Asp Thr Gly Lys Tyr Cys Phe Gly 
    290                 295                 300                 


Val Glu Asp Thr Leu Lys Ala Leu Glu Met Gly Ala Val Glu Ile Leu 
305                 310                 315                 320 


Ile Val Tyr Glu Asn Leu Asp Ile Met Arg Tyr Val Leu His Cys Gln 
                325                 330                 335     


Gly Thr Glu Glu Glu Lys Ile Leu Tyr Leu Thr Pro Glu Gln Glu Lys 
            340                 345                 350         


Asp Lys Ser His Phe Thr Asp Lys Glu Thr Gly Gln Glu His Glu Leu 
        355                 360                 365             


Ile Glu Ser Met Pro Leu Leu Glu Trp Phe Ala Asn Asn Tyr Lys Lys 
    370                 375                 380                 


Phe Gly Ala Thr Leu Glu Ile Val Thr Asp Lys Ser Gln Glu Gly Ser 
385                 390                 395                 400 


Gln Phe Val Lys Gly Phe Gly Gly Ile Gly Gly Ile Leu Arg Tyr Arg 
                405                 410                 415     


Val Asp Phe Gln Gly Met Glu Tyr Gln Gly Gly Asp Asp Glu Phe Phe 
            420                 425                 430         


Asp Leu Asp Asp Tyr 
        435         


<210>  1166
<211>  3778
<212>  DNA
<213>  Homosapiens

<400>  1166
ccatttcctc ctcctagccg gactggaggg agacaaagca gcgcccgtct gcttcgggcc     60

tctggaattt agcgctcgcc cagctagccg cagaaatgac tgctgtccat gcaggcaaca    120

taaacttcaa gtgggatcct aaaagtctag agatcaggac tctggcagtt gagagactgt    180

tggagcctct tgttacacag gttacaaccc ttgtaaacac caatagtaaa gggccctcta    240

ataagaagag aggtcgttct aagaaggccc atgttttggc tgcatctgtt gaacaagcaa    300

ctgagaattt cttggagaag ggggataaaa ttgcgaagga gagccagttt ctcaaggagg    360

agcttgtggc tgctgtagaa gatgttcgaa aacaaggtga tttgatgaag gctgctgcag    420

gagagttcgc agatgatccc tgctcttctg tgaagcgagg caacatggtt cgggcagctc    480

gagctttgct ctctgctgtt acccggttgc tgattttggc tgacatggca gatgtctaca    540

aattacttgt tcagctgaaa gttgtggaag atggtatctt gaagttgagg aatgctggca    600

atgaacaaga cttaggaatc cagtataaag ccctaaaacc tgaagtggat aagctgaaca    660

ttatggcagc caaaagacaa caggaattga aagatgttgg ccatcgtgat cagatggctg    720

cagctagagg aatcctgcag aagaacgttc cgatcctcta tactgcatcc caggcatgcc    780

tacagcaccc tgatgtcgca gcctataagg ccaacaggga cctgatatac aagcagctgc    840

agcaggcggt cacaggcatt tccaatgcag cccaggccac tgcctcagac gatgcctcac    900

agcaccaggg tggaggagga ggagaactgg catatgcact caataacttt gacaaacaaa    960

tcattgtgga ccccttgagc ttcagcgagg agcgctttag gccttccctg gaggagcgtc   1020

tggaaagcat cattagtggg gctgccttga tggccgactc gtcctgcacg cgtgatgacc   1080

gtcgtgagcg aattgtggca gagtgtaatg ctgtccgcca ggccctgcag gacctgcttt   1140

cggagtacat gggcaatgct ggacgtaaag aaagaagtga tgcactcaat tctgcaatag   1200

ataaaatgac caagaagacc agggacttgc gtagacagct ccgcaaagct gtcatggacc   1260

acgtttcaga ttctttcctg gaaaccaatg ttccactttt ggtattgatt gaagctgcaa   1320

agaatggaaa tgagaaagaa gttaaggagt atgcccaagt tttccgtgaa catgccaaca   1380

aattgattga ggttgccaac ttggcctgtt ccatctcaaa taatgaagaa ggtgtaaagc   1440

ttgttcgaat gtctgcaagc cagttagaag ccctctgtcc tcaggttatt aatgctgcac   1500

tggctttagc agcaaaacca cagagtaaac tggcccaaga gaacatggat ctttttaaag   1560

aacaatggga aaaacaagtc cgtgttctca cagatgctgt cgatgacatt acttccattg   1620

atgacttctt ggctgtctca gagaatcaca ttttggaaga tgtgaacaaa tgtgtcattg   1680

ctctccaaga gaaggatgtg gatggcctgg accgcacagc tggtgcaatt cgaggccggg   1740

cagcccgggt cattcacgta gtcacctcag agatggacaa ctatgagcca ggagtctaca   1800

cagagaaggt tctggaagcc actaagctgc tctccaacac agtcatgcca cgttttactg   1860

agcaagtaga agcagccgtg gaagccctca gctcggaccc tgcccagccc atggatgaga   1920

atgagtttat cgatgcttcc cgcctggtat atgatggcat ccgggacatc aggaaagcag   1980

tgctgatgat aaggacccct gaggagttgg atgactctga ctttgagaca gaagattttg   2040

atgtcagaag caggacgagc gtccagacag aagacgatca gctgatagct ggccagagtg   2100

cccgggcgat catggctcag cttccccagg agcaaaaagc gaagattgcg gaacaggtgg   2160

ccagcttcca ggaagaaaag agcaagctgg atgctgaagt gtccaaatgg gacgacagtg   2220

gcaatgacat cattgtgctg gccaagcaga tgtgcatgat tatgatggag atgacagact   2280

ttacccgagg taaaggacca ctcaaaaata catcggatgt catcagtgct gccaagaaaa   2340

ttgctgaggc aggatccagg atggacaagc ttggccgcac cattgcagac cattgccccg   2400

actcggcttg caagcaggac ctgctggcct acctgcaacg catcgccctc tactgccacc   2460

agctgaacat ctgcagcaag gtcaaggccg aggtgcagaa tctcggcggg gagcttgttg   2520

tctctggggt ggacagcgcc atgtccctga tccaggcagc caagaacttg atgaatgctg   2580

tggtgcagac agtgaaggca tcctacgtcg cctctaccaa ataccaaaag tcacagggta   2640

tggcttccct caaccttcct gctgtgtcat ggaagatgaa ggcaccagag aaaaagccat   2700

tggtgaagag agagaaacag gatgagacac agaccaagat taaacgggca tctcagaaga   2760

agcacgtgaa cccggtgcag gccctcagcg agttcaaagc tatggacagc atctaagtct   2820

gcccaggccg gccgccccca cccctcgggg ctcctgaata tcagtcactg ttcgtcactc   2880

aaatgaattt gctaaataca acactgatac tagattccac agggaaatgg gcagactgaa   2940

ccagtccagg tggtgaattt tccaagaaca tagtttaagt tgattaaaaa tgcttttaga   3000

atgcaggagc ctacttctag ctgtattttt tgtatgctta aataaaaata aaaattcata   3060

accaaagaga atcccacatt agcttgttag taatgctctg accaagccga gatgcccatt   3120

ctcttagtga tggcggcgtt agggtttgag agaagggaat ttggctcaac ttcagttgag   3180

agggtgcagt ccagacagct tgactgcttt taaatgacca aagatgacct gtggtaagca   3240

acctgggcat cttaggaagc agtccctgga gaaggcatgt tcccagaaag gtctctggag   3300

ggacaaactc actcagtaaa acataatgta tcatgaagaa aactgattct ctatgacatg   3360

aaatgaaaat tttaatgcat tgttataatt actaatgtac gctgctgcag gacattaata   3420

aagttgcttt tttaggctac agtgtctcga tgccataatc agaacacact ttttttcctc   3480

tttctcccag cttcaaatgc aaattcatca ttgggctcac ttctaataac tgcagtgttt   3540

cccgccttgg gcttgcagca gaaaaacctg acaacatagt gtttgctaag gcagtaattt   3600

agactttacc ttatttgtga ttactgtagt gattgattga ttgattacta ttaactacaa   3660

ggtataattt actatcacct tatttaaatt ttatgaatta atttgaatgt tttttacact   3720

aactaacttt tcccaataaa gtccactatg aaaccacgac aaaaaaaaaa aaaaaaaa     3778


<210>  1167
<211>  906
<212>  PRT
<213>  Homosapiens

<400>  1167

Met Thr Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Thr Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Thr Gln Val Thr Thr Leu Val Asn Thr Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Thr Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp 
                85                  90                  95      


Val Arg Lys Gln Gly Asp Leu Met Lys Ala Ala Ala Gly Glu Phe Ala 
            100                 105                 110         


Asp Asp Pro Cys Ser Ser Val Lys Arg Gly Asn Met Val Arg Ala Ala 
        115                 120                 125             


Arg Ala Leu Leu Ser Ala Val Thr Arg Leu Leu Ile Leu Ala Asp Met 
    130                 135                 140                 


Ala Asp Val Tyr Lys Leu Leu Val Gln Leu Lys Val Val Glu Asp Gly 
145                 150                 155                 160 


Ile Leu Lys Leu Arg Asn Ala Gly Asn Glu Gln Asp Leu Gly Ile Gln 
                165                 170                 175     


Tyr Lys Ala Leu Lys Pro Glu Val Asp Lys Leu Asn Ile Met Ala Ala 
            180                 185                 190         


Lys Arg Gln Gln Glu Leu Lys Asp Val Gly His Arg Asp Gln Met Ala 
        195                 200                 205             


Ala Ala Arg Gly Ile Leu Gln Lys Asn Val Pro Ile Leu Tyr Thr Ala 
    210                 215                 220                 


Ser Gln Ala Cys Leu Gln His Pro Asp Val Ala Ala Tyr Lys Ala Asn 
225                 230                 235                 240 


Arg Asp Leu Ile Tyr Lys Gln Leu Gln Gln Ala Val Thr Gly Ile Ser 
                245                 250                 255     


Asn Ala Ala Gln Ala Thr Ala Ser Asp Asp Ala Ser Gln His Gln Gly 
            260                 265                 270         


Gly Gly Gly Gly Glu Leu Ala Tyr Ala Leu Asn Asn Phe Asp Lys Gln 
        275                 280                 285             


Ile Ile Val Asp Pro Leu Ser Phe Ser Glu Glu Arg Phe Arg Pro Ser 
    290                 295                 300                 


Leu Glu Glu Arg Leu Glu Ser Ile Ile Ser Gly Ala Ala Leu Met Ala 
305                 310                 315                 320 


Asp Ser Ser Cys Thr Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu 
                325                 330                 335     


Cys Asn Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met 
            340                 345                 350         


Gly Asn Ala Gly Arg Lys Glu Arg Ser Asp Ala Leu Asn Ser Ala Ile 
        355                 360                 365             


Asp Lys Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys 
    370                 375                 380                 


Ala Val Met Asp His Val Ser Asp Ser Phe Leu Glu Thr Asn Val Pro 
385                 390                 395                 400 


Leu Leu Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val 
                405                 410                 415     


Lys Glu Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu 
            420                 425                 430         


Val Ala Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys 
        435                 440                 445             


Leu Val Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Val 
    450                 455                 460                 


Ile Asn Ala Ala Leu Ala Leu Ala Ala Lys Pro Gln Ser Lys Leu Ala 
465                 470                 475                 480 


Gln Glu Asn Met Asp Leu Phe Lys Glu Gln Trp Glu Lys Gln Val Arg 
                485                 490                 495     


Val Leu Thr Asp Ala Val Asp Asp Ile Thr Ser Ile Asp Asp Phe Leu 
            500                 505                 510         


Ala Val Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile 
        515                 520                 525             


Ala Leu Gln Glu Lys Asp Val Asp Gly Leu Asp Arg Thr Ala Gly Ala 
    530                 535                 540                 


Ile Arg Gly Arg Ala Ala Arg Val Ile His Val Val Thr Ser Glu Met 
545                 550                 555                 560 


Asp Asn Tyr Glu Pro Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr 
                565                 570                 575     


Lys Leu Leu Ser Asn Thr Val Met Pro Arg Phe Thr Glu Gln Val Glu 
            580                 585                 590         


Ala Ala Val Glu Ala Leu Ser Ser Asp Pro Ala Gln Pro Met Asp Glu 
        595                 600                 605             


Asn Glu Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Ile Arg Asp 
    610                 615                 620                 


Ile Arg Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Asp Asp 
625                 630                 635                 640 


Ser Asp Phe Glu Thr Glu Asp Phe Asp Val Arg Ser Arg Thr Ser Val 
                645                 650                 655     


Gln Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile 
            660                 665                 670         


Met Ala Gln Leu Pro Gln Glu Gln Lys Ala Lys Ile Ala Glu Gln Val 
        675                 680                 685             


Ala Ser Phe Gln Glu Glu Lys Ser Lys Leu Asp Ala Glu Val Ser Lys 
    690                 695                 700                 


Trp Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys 
705                 710                 715                 720 


Met Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu 
                725                 730                 735     


Lys Asn Thr Ser Asp Val Ile Ser Ala Ala Lys Lys Ile Ala Glu Ala 
            740                 745                 750         


Gly Ser Arg Met Asp Lys Leu Gly Arg Thr Ile Ala Asp His Cys Pro 
        755                 760                 765             


Asp Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala 
    770                 775                 780                 


Leu Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val 
785                 790                 795                 800 


Gln Asn Leu Gly Gly Glu Leu Val Val Ser Gly Val Asp Ser Ala Met 
                805                 810                 815     


Ser Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Gln Thr 
            820                 825                 830         


Val Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Ser Gln Gly 
        835                 840                 845             


Met Ala Ser Leu Asn Leu Pro Ala Val Ser Trp Lys Met Lys Ala Pro 
    850                 855                 860                 


Glu Lys Lys Pro Leu Val Lys Arg Glu Lys Gln Asp Glu Thr Gln Thr 
865                 870                 875                 880 


Lys Ile Lys Arg Ala Ser Gln Lys Lys His Val Asn Pro Val Gln Ala 
                885                 890                 895     


Leu Ser Glu Phe Lys Ala Met Asp Ser Ile 
            900                 905     


<210>  1168
<211>  1996
<212>  DNA
<213>  Homosapiens

<400>  1168
accggctcag acggtcgccg ccgcgtttgc gcagggggag ctggtcgccg ccgcggccgc     60

ctggaattgt gggagttgtg tctgccactc ggctgccgga ggccgaaggc cagctattac    120

ttctctactg aggccaactg tgagccctgg tgtgtttcat tggcaggaga agaggctaat    180

taagtgaaac tgaaaggtcc ctgactatgg ctccccagag cctgccttca tctaggatgg    240

ctcctctggg catgctgctt gggctgctga tggccgcctg cttcaccttc tgcctcagtc    300

atcagaacct gaaggagttt gccctgacca acccagagaa gagcagcacc aaagaaacag    360

agagaaaaga aaccaaagcc gaggaggagc tggatgccga agtcctggag gtgttccacc    420

cgacgcatga gtggcaggcc cttcagccag ggcaggctgt ccctgcagga tcccacgtac    480

ggctgaatct tcagactggg gaaagagagg caaaactcca atatgaggac aagttccgaa    540

ataatttgaa aggcaaaagg ctggatatca acaccaacac ctacacatct caggatctca    600

agagtgcact ggcaaaattc aaggaggggg cagagatgga gagttcaaag gaagacaagg    660

caaggcaggc tgaggtaaag cggctcttcc gccccattga ggaactgaag aaagactttg    720

atgagctgaa tgttgtcatt gagactgaca tgcagatcat ggtacggctg atcaacaagt    780

tcaatagttc cagctccagt ttggaagaga agattgctgc gctctttgat cttgaatatt    840

atgtccatca gatggacaat gcgcaggacc tgctttcctt tggtggtctt caagtggtga    900

tcaatgggct gaacagcaca gagcccctcg tgaaggagta tgctgcgttt gtgctgggcg    960

ctgccttttc cagcaacccc aaggtccagg tggaggccat cgaaggggga gccctgcaga   1020

agctgctggt catcctggcc acggagcagc cgctcactgc aaagaagaag gtcctgtttg   1080

cactgtgctc cctgctgcgc cacttcccct atgcccagcg gcagttcctg aagctcgggg   1140

ggctgcaggt cctgaggacc ctggtgcagg agaagggcac ggaggtgctc gccgtgcgcg   1200

tggtcacact gctctacgac ctggtcacgg agaagatgtt cgccgaggag gaggctgagc   1260

tgacccagga gatgtcccca gagaagctgc agcagtatcg ccaggtacac ctcctgccag   1320

gcctgtggga acagggctgg tgcgagatca cggcccacct cctggcgctg cccgagcatg   1380

atgcccgtga gaaggtgctg cagacactgg gcgtcctcct gaccacctgc cgggaccgct   1440

accgtcagga cccccagctc ggcaggacac tggccagcct gcaggctgag taccaggtgc   1500

tggccagcct ggagctgcag gatggtgagg acgagggcta cttccaggag ctgctgggct   1560

ctgtcaacag cttgctgaag gagctgagat gaggccccac accaggactg gactgggatg   1620

ccgctagtga ggctgagggg tgccagcgtg ggtgggcttc tcaggcagga ggacatcttg   1680

gcagtgctgg cttggccatt aaatggaaac ctgaaggcca tcctctttct gctgtgtgtc   1740

tgtgtagact gggcacagcc ctgtggccgg ggggtcaggt gagtggttgg gtgatgggct   1800

ctgctgacgt gcagggctca gcccagggca tccaggaaca ggctccaggg caggaacctg   1860

ggcccaggag ttgcaagtct ctgcttctta ccaagcagca gctctgtacc ttgggaagtc   1920

gcttaattgc tctgagcttg tttcctcatc tgtcaggagt gccattaaag gagaaaaatc   1980

acgtagaaaa aaaaaa                                                   1996


<210>  1169
<211>  461
<212>  PRT
<213>  Homosapiens

<400>  1169

Met Ala Pro Gln Ser Leu Pro Ser Ser Arg Met Ala Pro Leu Gly Met 
1               5                   10                  15      


Leu Leu Gly Leu Leu Met Ala Ala Cys Phe Thr Phe Cys Leu Ser His 
            20                  25                  30          


Gln Asn Leu Lys Glu Phe Ala Leu Thr Asn Pro Glu Lys Ser Ser Thr 
        35                  40                  45              


Lys Glu Thr Glu Arg Lys Glu Thr Lys Ala Glu Glu Glu Leu Asp Ala 
    50                  55                  60                  


Glu Val Leu Glu Val Phe His Pro Thr His Glu Trp Gln Ala Leu Gln 
65                  70                  75                  80  


Pro Gly Gln Ala Val Pro Ala Gly Ser His Val Arg Leu Asn Leu Gln 
                85                  90                  95      


Thr Gly Glu Arg Glu Ala Lys Leu Gln Tyr Glu Asp Lys Phe Arg Asn 
            100                 105                 110         


Asn Leu Lys Gly Lys Arg Leu Asp Ile Asn Thr Asn Thr Tyr Thr Ser 
        115                 120                 125             


Gln Asp Leu Lys Ser Ala Leu Ala Lys Phe Lys Glu Gly Ala Glu Met 
    130                 135                 140                 


Glu Ser Ser Lys Glu Asp Lys Ala Arg Gln Ala Glu Val Lys Arg Leu 
145                 150                 155                 160 


Phe Arg Pro Ile Glu Glu Leu Lys Lys Asp Phe Asp Glu Leu Asn Val 
                165                 170                 175     


Val Ile Glu Thr Asp Met Gln Ile Met Val Arg Leu Ile Asn Lys Phe 
            180                 185                 190         


Asn Ser Ser Ser Ser Ser Leu Glu Glu Lys Ile Ala Ala Leu Phe Asp 
        195                 200                 205             


Leu Glu Tyr Tyr Val His Gln Met Asp Asn Ala Gln Asp Leu Leu Ser 
    210                 215                 220                 


Phe Gly Gly Leu Gln Val Val Ile Asn Gly Leu Asn Ser Thr Glu Pro 
225                 230                 235                 240 


Leu Val Lys Glu Tyr Ala Ala Phe Val Leu Gly Ala Ala Phe Ser Ser 
                245                 250                 255     


Asn Pro Lys Val Gln Val Glu Ala Ile Glu Gly Gly Ala Leu Gln Lys 
            260                 265                 270         


Leu Leu Val Ile Leu Ala Thr Glu Gln Pro Leu Thr Ala Lys Lys Lys 
        275                 280                 285             


Val Leu Phe Ala Leu Cys Ser Leu Leu Arg His Phe Pro Tyr Ala Gln 
    290                 295                 300                 


Arg Gln Phe Leu Lys Leu Gly Gly Leu Gln Val Leu Arg Thr Leu Val 
305                 310                 315                 320 


Gln Glu Lys Gly Thr Glu Val Leu Ala Val Arg Val Val Thr Leu Leu 
                325                 330                 335     


Tyr Asp Leu Val Thr Glu Lys Met Phe Ala Glu Glu Glu Ala Glu Leu 
            340                 345                 350         


Thr Gln Glu Met Ser Pro Glu Lys Leu Gln Gln Tyr Arg Gln Val His 
        355                 360                 365             


Leu Leu Pro Gly Leu Trp Glu Gln Gly Trp Cys Glu Ile Thr Ala His 
    370                 375                 380                 


Leu Leu Ala Leu Pro Glu His Asp Ala Arg Glu Lys Val Leu Gln Thr 
385                 390                 395                 400 


Leu Gly Val Leu Leu Thr Thr Cys Arg Asp Arg Tyr Arg Gln Asp Pro 
                405                 410                 415     


Gln Leu Gly Arg Thr Leu Ala Ser Leu Gln Ala Glu Tyr Gln Val Leu 
            420                 425                 430         


Ala Ser Leu Glu Leu Gln Asp Gly Glu Asp Glu Gly Tyr Phe Gln Glu 
        435                 440                 445             


Leu Leu Gly Ser Val Asn Ser Leu Leu Lys Glu Leu Arg 
    450                 455                 460     


<210>  1170
<211>  1908
<212>  DNA
<213>  Homosapiens

<400>  1170
accggctcag acggtcgccg ccgcgtttgc gcagggggag ctggtcgccg ccgcggccgc     60

ctggaattgt gggagttgtg tctgccactc ggctgccgga ggccgaaggt ccctgactat    120

ggctccccag agcctgcctt catctaggat ggctcctctg ggcatgctgc ttgggctgct    180

gatggccgcc tgcttcacct tctgcctcag tcatcagaac ctgaaggagt ttgccctgac    240

caacccagag aagagcagca ccaaagaaac agagagaaaa gaaaccaaag ccgaggagga    300

gctggatgcc gaagtcctgg aggtgttcca cccgacgcat gagtggcagg cccttcagcc    360

agggcaggct gtccctgcag gatcccacgt acggctgaat cttcagactg gggaaagaga    420

ggcaaaactc caatatgagg acaagttccg aaataatttg aaaggcaaaa ggctggatat    480

caacaccaac acctacacat ctcaggatct caagagtgca ctggcaaaat tcaaggaggg    540

ggcagagatg gagagttcaa aggaagacaa ggcaaggcag gctgaggtaa agcggctctt    600

ccgccccatt gaggaactga agaaagactt tgatgagctg aatgttgtca ttgagactga    660

catgcagatc atggtacggc tgatcaacaa gttcaatagt tccagctcca gtttggaaga    720

gaagattgct gcgctctttg atcttgaata ttatgtccat cagatggaca atgcgcagga    780

cctgctttcc tttggtggtc ttcaagtggt gatcaatggg ctgaacagca cagagcccct    840

cgtgaaggag tatgctgcgt ttgtgctggg cgctgccttt tccagcaacc ccaaggtcca    900

ggtggaggcc atcgaagggg gagccctgca gaagctgctg gtcatcctgg ccacggagca    960

gccgctcact gcaaagaaga aggtcctgtt tgcactgtgc tccctgctgc gccacttccc   1020

ctatgcccag cggcagttcc tgaagctcgg ggggctgcag gtcctgagga ccctggtgca   1080

ggagaagggc acggaggtgc tcgccgtgcg cgtggtcaca ctgctctacg acctggtcac   1140

ggagaagatg ttcgccgagg aggaggctga gctgacccag gagatgtccc cagagaagct   1200

gcagcagtat cgccaggtac acctcctgcc aggcctgtgg gaacagggct ggtgcgagat   1260

cacggcccac ctcctggcgc tgcccgagca tgatgcccgt gagaaggtgc tgcagacact   1320

gggcgtcctc ctgaccacct gccgggaccg ctaccgtcag gacccccagc tcggcaggac   1380

actggccagc ctgcaggctg agtaccaggt gctggccagc ctggagctgc aggatggtga   1440

ggacgagggc tacttccagg agctgctggg ctctgtcaac agcttgctga aggagctgag   1500

atgaggcccc acaccaggac tggactggga tgccgctagt gaggctgagg ggtgccagcg   1560

tgggtgggct tctcaggcag gaggacatct tggcagtgct ggcttggcca ttaaatggaa   1620

acctgaaggc catcctcttt ctgctgtgtg tctgtgtaga ctgggcacag ccctgtggcc   1680

ggggggtcag gtgagtggtt gggtgatggg ctctgctgac gtgcagggct cagcccaggg   1740

catccaggaa caggctccag ggcaggaacc tgggcccagg agttgcaagt ctctgcttct   1800

taccaagcag cagctctgta ccttgggaag tcgcttaatt gctctgagct tgtttcctca   1860

tctgtcagga gtgccattaa aggagaaaaa tcacgtagaa aaaaaaaa                1908


<210>  1171
<211>  461
<212>  PRT
<213>  Homosapiens

<400>  1171

Met Ala Pro Gln Ser Leu Pro Ser Ser Arg Met Ala Pro Leu Gly Met 
1               5                   10                  15      


Leu Leu Gly Leu Leu Met Ala Ala Cys Phe Thr Phe Cys Leu Ser His 
            20                  25                  30          


Gln Asn Leu Lys Glu Phe Ala Leu Thr Asn Pro Glu Lys Ser Ser Thr 
        35                  40                  45              


Lys Glu Thr Glu Arg Lys Glu Thr Lys Ala Glu Glu Glu Leu Asp Ala 
    50                  55                  60                  


Glu Val Leu Glu Val Phe His Pro Thr His Glu Trp Gln Ala Leu Gln 
65                  70                  75                  80  


Pro Gly Gln Ala Val Pro Ala Gly Ser His Val Arg Leu Asn Leu Gln 
                85                  90                  95      


Thr Gly Glu Arg Glu Ala Lys Leu Gln Tyr Glu Asp Lys Phe Arg Asn 
            100                 105                 110         


Asn Leu Lys Gly Lys Arg Leu Asp Ile Asn Thr Asn Thr Tyr Thr Ser 
        115                 120                 125             


Gln Asp Leu Lys Ser Ala Leu Ala Lys Phe Lys Glu Gly Ala Glu Met 
    130                 135                 140                 


Glu Ser Ser Lys Glu Asp Lys Ala Arg Gln Ala Glu Val Lys Arg Leu 
145                 150                 155                 160 


Phe Arg Pro Ile Glu Glu Leu Lys Lys Asp Phe Asp Glu Leu Asn Val 
                165                 170                 175     


Val Ile Glu Thr Asp Met Gln Ile Met Val Arg Leu Ile Asn Lys Phe 
            180                 185                 190         


Asn Ser Ser Ser Ser Ser Leu Glu Glu Lys Ile Ala Ala Leu Phe Asp 
        195                 200                 205             


Leu Glu Tyr Tyr Val His Gln Met Asp Asn Ala Gln Asp Leu Leu Ser 
    210                 215                 220                 


Phe Gly Gly Leu Gln Val Val Ile Asn Gly Leu Asn Ser Thr Glu Pro 
225                 230                 235                 240 


Leu Val Lys Glu Tyr Ala Ala Phe Val Leu Gly Ala Ala Phe Ser Ser 
                245                 250                 255     


Asn Pro Lys Val Gln Val Glu Ala Ile Glu Gly Gly Ala Leu Gln Lys 
            260                 265                 270         


Leu Leu Val Ile Leu Ala Thr Glu Gln Pro Leu Thr Ala Lys Lys Lys 
        275                 280                 285             


Val Leu Phe Ala Leu Cys Ser Leu Leu Arg His Phe Pro Tyr Ala Gln 
    290                 295                 300                 


Arg Gln Phe Leu Lys Leu Gly Gly Leu Gln Val Leu Arg Thr Leu Val 
305                 310                 315                 320 


Gln Glu Lys Gly Thr Glu Val Leu Ala Val Arg Val Val Thr Leu Leu 
                325                 330                 335     


Tyr Asp Leu Val Thr Glu Lys Met Phe Ala Glu Glu Glu Ala Glu Leu 
            340                 345                 350         


Thr Gln Glu Met Ser Pro Glu Lys Leu Gln Gln Tyr Arg Gln Val His 
        355                 360                 365             


Leu Leu Pro Gly Leu Trp Glu Gln Gly Trp Cys Glu Ile Thr Ala His 
    370                 375                 380                 


Leu Leu Ala Leu Pro Glu His Asp Ala Arg Glu Lys Val Leu Gln Thr 
385                 390                 395                 400 


Leu Gly Val Leu Leu Thr Thr Cys Arg Asp Arg Tyr Arg Gln Asp Pro 
                405                 410                 415     


Gln Leu Gly Arg Thr Leu Ala Ser Leu Gln Ala Glu Tyr Gln Val Leu 
            420                 425                 430         


Ala Ser Leu Glu Leu Gln Asp Gly Glu Asp Glu Gly Tyr Phe Gln Glu 
        435                 440                 445             


Leu Leu Gly Ser Val Asn Ser Leu Leu Lys Glu Leu Arg 
    450                 455                 460     


<210>  1172
<211>  3921
<212>  DNA
<213>  Homosapiens

<400>  1172
gcgagagtgg gtttgttctt gggctgcagc cgctgccgcc gcttctcgcc agcgccgttg     60

ctgcggggga ttgtgggagt ctccgcgtcc cgctcgctgg gagagaggta cctctccttt    120

tccctctccc tttccctaag agttgtctgc tggttctcag cttgaagaag attctgcagt    180

ccttattgat cctttttctt ggcgttacca tttttgaagc aaagttaacc tagctttcta    240

gtttgagctt tctttttggc cgtctttaaa aaaatttttt tttttaatct ataaaataga    300

caagagctag ttctacaatg tccaagtcat tccagcagtc atctctcagt agggactcac    360

agggtcatgg gcgtgacctg tctgcggcag gaataggcct tcttgctgct gctacccagt    420

ctttaagtat gccagcatct cttggaagga tgaaccaggg tactgcacgc cttgctagtt    480

taatgaatct tggaatgagt tcttcattga atcaacaagg agctcatagt gcactgtctt    540

ctgctagtac ttcttcccat aatttgcagt ctatatttaa cattggaagt agaggtccac    600

tccctttatc ttctcaacac cgtggagatg cagaccaggc cagtaacatt ttggccagct    660

ttggtctgtc tgctagagac ttagatgaac tgagtcgtta tccagaggac aagattactc    720

ctgagaattt gccccaaatc cttctacagc ttaaaaggag gagaactgaa gaaggcccta    780

ccttgagtta tggtagagat ggcagatctg ctacacggga gccaccatac agagtaccta    840

gggatgattg ggaagaaaaa aggcacttta gaagagatag ttttgatgat cgtggtccta    900

gtctcaaccc agtgcttgat tatgaccatg gaagtcgttc tcaagaatct ggttattatg    960

acagaatgga ttatgaagat gacagattaa gagatggaga aaggtgtagg gatgattctt   1020

tttttggtga gacctcgcat aactatcata aatttgacag tgagtatgag agaatgggac   1080

gtggtcctgg ccccttacaa gagagatctc tctttgagaa aaagagaggc gctcctccaa   1140

gtagcaatat tgaagacttc catggactct taccgaaggg ttatccccat ctgtgctcta   1200

tatgtgattt gccagttcat tctaataagg agtggagtca acatatcaat ggagcaagtc   1260

acagtcgtcg atgccagctt cttcttgaaa tctacccaga atggaatcct gacaatgata   1320

caggacacac aatgggtgat ccattcatgt tgcagcagtc tacaaatcca gcaccaggaa   1380

ttctgggacc tccacctccc tcatttcatc ttgggggacc agcagttgga ccaagaggaa   1440

atctgggtgc tggaaatgga aacctgcaag gacctagaca catgcagaaa ggcagagtgg   1500

aaactagcag agttgttcac atcatggatt ttcaacgagg gaaaaacttg agataccagc   1560

tattacagct ggtagaacca tttggagtca tttcaaatca tctgattcta aataaaatta   1620

atgaggcatt tattgaaatg gcaaccacag aggatgctca ggccgcagtg gattattaca   1680

caaccacacc agcgttagta tttggcaagc cagtgagagt tcatttatcc cagaagtata   1740

aaagaataaa gaaacctgaa ggaaagccag atcagaagtt tgatcaaaag caagagcttg   1800

gacgtgtgat acatctcagc aatttgccgc attctggcta ttctgatagt gctgttctca   1860

agcttgctga gccttatggg aaaataaaga attacatatt gatgaggatg aaaagtcagg   1920

cttttattga gatggagaca agagaagatg caatggcaat ggttgaccat tgtttgaaaa   1980

aagccctttg gtttcagggg agatgtgtga aggttgacct gtctgagaaa tataaaaaac   2040

tggttctgag gattccaaac agaggcattg atttactgaa aaaagataaa tcccgaaaaa   2100

gatcttactc tccagatggc aaagaatctc caagtgataa gaaatccaaa actgatggtt   2160

cccagaagac tgagagttca accgaaggta aagaacaaga agagaagtcc ggtgaagatg   2220

gtgagaaaga cacaaaggat gaccagacag agcaggaacc taatatgctt cttgaatctg   2280

aagatgagct acttgtagat gaagaagaag cagcagcact gctagaaagt ggcagttcag   2340

tgggagacga gaccgatctt gctaatttag gtgatgtggc ttctgatggg aaaaaggaac   2400

catcagataa agctgtgaaa aaagatggaa gtgcttcagc agcagcaaag aaaaagctta   2460

aaaaggtgga caagatcgag gaacttgatc aagaaaacga agcagcgttg gaaaatggaa   2520

ttaaaaatga ggaaaacaca gaaccaggtg ctgaatcttc tgagaacgct gatgatccca   2580

acaaagatac aagtgaaaac gcagatggtc aaagtgatga gaacaaggac gactatacaa   2640

tcccagatga gtatagaatt ggaccatatc agcccaatgt tcctgttggt atagactatg   2700

tgatacctaa aacagggttt tactgtaagc tgtgttcact cttttataca aatgaagaag   2760

ttgcaaagaa tactcattgc agcagccttc ctcattatca gaaattaaag aaatttctga   2820

ataaattggc agaagaacgc agacagaaga aggaaactta agatgtgcaa ggagatttaa   2880

tgatttcaaa gaaaataatg gttctttgtt tttaatgtta acctttttta aatacaatac   2940

tgatagttag aagaaaacta ttgtactctt ttgttttagt ggagaaataa tagatgtctg   3000

ttcatgtgtt aagtgttata gcaaaaaaaa tacacatatg gttaagttaa tgaatagttt   3060

ttgttttatc agaatggcaa cagacagaag tactttgtag agattgactt cctaagctac   3120

ttaagacaac ttgcaccact aagaaaaaaa tgtagaacca tttggaaaaa tgaaatttag   3180

tagttccaag tttcaaagaa atgtcaacat tttattccat tcaataaaga acaaaaccaa   3240

tagtgttttt attactttca tctgaaacat tccatgtttt aatctgagcc ttgcagactt   3300

tcatttggag tttgaacccg ttttggttgc atttcatttt tggagaactt aattaacgtg   3360

agattggcaa ttgaaatgca ggtgcagttt tctgttaatg tcatgctgtt gtttaggtaa   3420

taagaaatat taagtaattg gctttagatt ttgtaatttt tttccctgag ttcctgctag   3480

atttcgtatt ctagtagtca atgtattttc agtgaaatgc aaaaatattc ccgttatctt   3540

tgaccagtat taatttttga gatcttactg cttgtcactt gaatcccgtg attgtcatac   3600

atctctggta taagcaacat ttgatttttg aagtgtgtag accatctctt catattttca   3660

agatgtaatt ttacatttct gcatttttaa aacagtttgg ccataatcct agatgcacgc   3720

ttctaattca tgtacctgca catgtgacct ttgtgaacag aaatttgcat gtataatttg   3780

tgtttacttg taactttctg gttatatact gcttatatct gtggattcaa gttactgaag   3840

tgaataccaa taaaaagaaa accctaggcc atgttaattg gttatacatg tttggaatgt   3900

taaccaaaaa aaaaaaaaaa a                                             3921


<210>  1173
<211>  847
<212>  PRT
<213>  Homosapiens

<400>  1173

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu 
            100                 105                 110         


Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 
        115                 120                 125             


Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln 
    130                 135                 140                 


Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg 
145                 150                 155                 160 


Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp 
                165                 170                 175     


Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg 
            180                 185                 190         


Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 
        195                 200                 205             


Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu 
    210                 215                 220                 


Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser 
225                 230                 235                 240 


His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly 
                245                 250                 255     


Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala 
            260                 265                 270         


Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 
        275                 280                 285             


Tyr Pro His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys 
    290                 295                 300                 


Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
305                 310                 315                 320 


Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
                325                 330                 335     


His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
            340                 345                 350         


Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
        355                 360                 365             


Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
    370                 375                 380                 


Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
385                 390                 395                 400 


His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                405                 410                 415     


Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
            420                 425                 430         


Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
        435                 440                 445             


Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
    450                 455                 460                 


Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
465                 470                 475                 480 


Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
                485                 490                 495     


Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
            500                 505                 510         


Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
        515                 520                 525             


Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
    530                 535                 540                 


Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
545                 550                 555                 560 


Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val 
                565                 570                 575     


Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 
            580                 585                 590         


Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys 
        595                 600                 605             


Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly 
    610                 615                 620                 


Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys 
625                 630                 635                 640 


Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp 
                645                 650                 655     


Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly 
            660                 665                 670         


Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala 
        675                 680                 685             


Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly 
    690                 695                 700                 


Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Val Asp Lys Ile 
705                 710                 715                 720 


Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys 
                725                 730                 735     


Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp 
            740                 745                 750         


Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu 
        755                 760                 765             


Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr 
    770                 775                 780                 


Gln Pro Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly 
785                 790                 795                 800 


Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala 
                805                 810                 815     


Lys Asn Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys 
            820                 825                 830         


Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
        835                 840                 845         


<210>  1174
<211>  4031
<212>  DNA
<213>  Homosapiens

<400>  1174
ctttcccctc cggcctctgc cggtgctgct gcgccctgcg gagctccgaa cacgtgcgca     60

gaggctggct gtggcagatg caactgcagg atgacttgaa agtagggcat ccttcaccca    120

tctgaaggga ggaaatagtg gcaggtgaca gtctgcatgt gcagttttca gatgccttca    180

cctgaatgac atctacctcc atcaggaccc cagatgtctg acagccctgt gtgacaccaa    240

gataagtaac agttgtctgc tggttctcag cttgaagaag attctgcagt ccttattgat    300

cctttttctt ggcgttacca tttttgaagc aaagttaacc tagctttcta gtttgagctt    360

tctttttggc cgtctttaaa aaaatttttt tttttaatct ataaaataga caagagctag    420

ttctacaatg tccaagtcat tccagcagtc atctctcagt agggactcac agggtcatgg    480

gcgtgacctg tctgcggcag gaataggcct tcttgctgct gctacccagt ctttaagtat    540

gccagcatct cttggaagga tgaaccaggg tactgcacgc cttgctagtt taatgaatct    600

tggaatgagt tcttcattga atcaacaagg agctcatagt gcactgtctt ctgctagtac    660

ttcttcccat aatttgcagt ctatatttaa cattggaagt agaggtccac tccctttatc    720

ttctcaacac cgtggagatg cagaccaggc cagtaacatt ttggccagct ttggtctgtc    780

tgctagagac ttagatgaac tgagtcgtta tccagaggac aagattactc ctgagaattt    840

gccccaaatc cttctacagc ttaaaaggag gagaactgaa gaaggcccta ccttgagtta    900

tggtagagat ggcagatctg ctacacggga gccaccatac agagtaccta gggatgattg    960

ggaagaaaaa aggcacttta gaagagatag ttttgatgat cgtggtccta gtctcaaccc   1020

agtgcttgat tatgaccatg gaagtcgttc tcaagaatct ggttattatg acagaatgga   1080

ttatgaagat gacagattaa gagatggaga aaggtgtagg gatgattctt tttttggtga   1140

gacctcgcat aactatcata aatttgacag tgagtatgag agaatgggac gtggtcctgg   1200

ccccttacaa gagagatctc tctttgagaa aaagagaggc gctcctccaa gtagcaatat   1260

tgaagacttc catggactct taccgaaggg ttatccccat ctgtgctcta tatgtgattt   1320

gccagttcat tctaataagg agtggagtca acatatcaat ggagcaagtc acagtcgtcg   1380

atgccagctt cttcttgaaa tctacccaga atggaatcct gacaatgata caggacacac   1440

aatgggtgat ccattcatgt tgcagcagtc tacaaatcca gcaccaggaa ttctgggacc   1500

tccacctccc tcatttcatc ttgggggacc agcagttgga ccaagaggaa atctgggtgc   1560

tggaaatgga aacctgcaag gacctagaca catgcagaaa ggcagagtgg aaactagcag   1620

agttgttcac atcatggatt ttcaacgagg gaaaaacttg agataccagc tattacagct   1680

ggtagaacca tttggagtca tttcaaatca tctgattcta aataaaatta atgaggcatt   1740

tattgaaatg gcaaccacag aggatgctca ggccgcagtg gattattaca caaccacacc   1800

agcgttagta tttggcaagc cagtgagagt tcatttatcc cagaagtata aaagaataaa   1860

gaaacctgaa ggaaagccag atcagaagtt tgatcaaaag caagagcttg gacgtgtgat   1920

acatctcagc aatttgccgc attctggcta ttctgatagt gctgttctca agcttgctga   1980

gccttatggg aaaataaaga attacatatt gatgaggatg aaaagtcagg cttttattga   2040

gatggagaca agagaagatg caatggcaat ggttgaccat tgtttgaaaa aagccctttg   2100

gtttcagggg agatgtgtga aggttgacct gtctgagaaa tataaaaaac tggttctgag   2160

gattccaaac agaggcattg atttactgaa aaaagataaa tcccgaaaaa gatcttactc   2220

tccagatggc aaagaatctc caagtgataa gaaatccaaa actgatggtt cccagaagac   2280

tgagagttca accgaaggta aagaacaaga agagaagtcc ggtgaagatg gtgagaaaga   2340

cacaaaggat gaccagacag agcaggaacc taatatgctt cttgaatctg aagatgagct   2400

acttgtagat gaagaagaag cagcagcact gctagaaagt ggcagttcag tgggagacga   2460

gaccgatctt gctaatttag gtgatgtggc ttctgatggg aaaaaggaac catcagataa   2520

agctgtgaaa aaagatggaa gtgcttcagc agcagcaaag aaaaagctta aaaaggtgga   2580

caagatcgag gaacttgatc aagaaaacga agcagcgttg gaaaatggaa ttaaaaatga   2640

ggaaaacaca gaaccaggtg ctgaatcttc tgagaacgct gatgatccca acaaagatac   2700

aagtgaaaac gcagatggtc aaagtgatga gaacaaggac gactatacaa tcccagatga   2760

gtatagaatt ggaccatatc agcccaatgt tcctgttggt atagactatg tgatacctaa   2820

aacagggttt tactgtaagc tgtgttcact cttttataca aatgaagaag ttgcaaagaa   2880

tactcattgc agcagccttc ctcattatca gaaattaaag aaatttctga ataaattggc   2940

agaagaacgc agacagaaga aggaaactta agatgtgcaa ggagatttaa tgatttcaaa   3000

gaaaataatg gttctttgtt tttaatgtta acctttttta aatacaatac tgatagttag   3060

aagaaaacta ttgtactctt ttgttttagt ggagaaataa tagatgtctg ttcatgtgtt   3120

aagtgttata gcaaaaaaaa tacacatatg gttaagttaa tgaatagttt ttgttttatc   3180

agaatggcaa cagacagaag tactttgtag agattgactt cctaagctac ttaagacaac   3240

ttgcaccact aagaaaaaaa tgtagaacca tttggaaaaa tgaaatttag tagttccaag   3300

tttcaaagaa atgtcaacat tttattccat tcaataaaga acaaaaccaa tagtgttttt   3360

attactttca tctgaaacat tccatgtttt aatctgagcc ttgcagactt tcatttggag   3420

tttgaacccg ttttggttgc atttcatttt tggagaactt aattaacgtg agattggcaa   3480

ttgaaatgca ggtgcagttt tctgttaatg tcatgctgtt gtttaggtaa taagaaatat   3540

taagtaattg gctttagatt ttgtaatttt tttccctgag ttcctgctag atttcgtatt   3600

ctagtagtca atgtattttc agtgaaatgc aaaaatattc ccgttatctt tgaccagtat   3660

taatttttga gatcttactg cttgtcactt gaatcccgtg attgtcatac atctctggta   3720

taagcaacat ttgatttttg aagtgtgtag accatctctt catattttca agatgtaatt   3780

ttacatttct gcatttttaa aacagtttgg ccataatcct agatgcacgc ttctaattca   3840

tgtacctgca catgtgacct ttgtgaacag aaatttgcat gtataatttg tgtttacttg   3900

taactttctg gttatatact gcttatatct gtggattcaa gttactgaag tgaataccaa   3960

taaaaagaaa accctaggcc atgttaattg gttatacatg tttggaatgt taaccaaaaa   4020

aaaaaaaaaa a                                                        4031


<210>  1175
<211>  847
<212>  PRT
<213>  Homosapiens

<400>  1175

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu 
            100                 105                 110         


Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 
        115                 120                 125             


Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln 
    130                 135                 140                 


Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg 
145                 150                 155                 160 


Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp 
                165                 170                 175     


Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg 
            180                 185                 190         


Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 
        195                 200                 205             


Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu 
    210                 215                 220                 


Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser 
225                 230                 235                 240 


His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly 
                245                 250                 255     


Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala 
            260                 265                 270         


Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 
        275                 280                 285             


Tyr Pro His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys 
    290                 295                 300                 


Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
305                 310                 315                 320 


Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
                325                 330                 335     


His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
            340                 345                 350         


Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
        355                 360                 365             


Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
    370                 375                 380                 


Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
385                 390                 395                 400 


His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                405                 410                 415     


Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
            420                 425                 430         


Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
        435                 440                 445             


Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
    450                 455                 460                 


Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
465                 470                 475                 480 


Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
                485                 490                 495     


Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
            500                 505                 510         


Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
        515                 520                 525             


Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
    530                 535                 540                 


Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
545                 550                 555                 560 


Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val 
                565                 570                 575     


Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 
            580                 585                 590         


Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys 
        595                 600                 605             


Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly 
    610                 615                 620                 


Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys 
625                 630                 635                 640 


Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp 
                645                 650                 655     


Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly 
            660                 665                 670         


Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala 
        675                 680                 685             


Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly 
    690                 695                 700                 


Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Val Asp Lys Ile 
705                 710                 715                 720 


Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys 
                725                 730                 735     


Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp 
            740                 745                 750         


Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu 
        755                 760                 765             


Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr 
    770                 775                 780                 


Gln Pro Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly 
785                 790                 795                 800 


Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala 
                805                 810                 815     


Lys Asn Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys 
            820                 825                 830         


Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
        835                 840                 845         


<210>  1176
<211>  1521
<212>  DNA
<213>  Homosapiens

<400>  1176
gggtttgggg agagaggggc ggagggactg gcgggctctt ggcgtcttgg gggaacgctg     60

caaccgtcga cgggcctgat cagaagatcg tctttctccc gtttcttcgc catcgctacc    120

ccttattttt ggttgtattg cagctcatgc cctggaaaaa agaacctttg gggttaaaaa    180

cgacaaccaa catcagccat gaaagatcca agtcgcagca gtactagccc aagcatcatc    240

aatgaagatg tgattattaa cggtcattct catgaagatg acaatccatt tgcagagtac    300

atgtggatgg aaaatgaaga agaattcaac agacaaatag aagaggagtt atgggaagaa    360

gaatttattg aacgctgttt ccaagaaatg ctggaagagg aagaagagca tgaatggttt    420

attccagctc gagatctccc acaaactatg gaccaaatcc aagaccagtt taatgacctt    480

gttatcagtg atggctcttc tctggaagat cttgtggtca agagcaatct gaatccaaat    540

gcaaaggagt ttgttcctgg ggtgaagtac ggaaatattt gagtagacgg ggccctcttt    600

tggtggatgt agcacaattt ccacactgtg aaggcagtat tagaagactt aattgtaaaa    660

gctctcttgt cactgtgtta cacttatgca ttgccaaagt ttttgttagt cttgcatgct    720

taataaaagt gctgagactg ttactaagta aaaagctgtc aaacatttac tgaaaataga    780

attggcccca tggcttgatg tgaagacagc aaggaaagaa gcaccagtca agttgtgaac    840

aagcaccaaa ttaaaagacc taaaccttac caaattgtct ttttttgagg ctaatctatc    900

acttgttaat gtctaaactt taaaatcagt acatttaatt tgagttccaa ctgttaagca    960

tatttctcag acttaaattt gattatgtcc ccatcaaaaa gaatctccat tttctgaagg   1020

tctgttagtt aatttgagat aatttgttaa aggcaagtat gtcatattac tgaggctaca   1080

agttagtcag cagatgagtg ccagtccagc cttttctggt atgttattgt tagaaatatt   1140

gagttctaat gttacatctg aggaagtatg taatttgaga attgtaactt ctaagggatt   1200

cactgcatca tagctatgcc tgtatggagt ctaacatatg accaatacca acccataatc   1260

cagctgaaca aagatactgt aacatgattt gagtggtgct tttccttgct ttgttaacca   1320

tcacgagagt ctgcagcaca acttttaaca aagctagaac agttttggct tcttaaactt   1380

catatttggg taggttaagc tgccatacgt gttcagtgtg aatagtgttt aagttgaaaa   1440

tattgtaaaa aaattatatt ttttcaaaaa tatttaaaaa aataaataat agtagaactg   1500

agcaaaaaaa aaaaaaaaaa a                                             1521


<210>  1177
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  1177

Met Lys Asp Pro Ser Arg Ser Ser Thr Ser Pro Ser Ile Ile Asn Glu 
1               5                   10                  15      


Asp Val Ile Ile Asn Gly His Ser His Glu Asp Asp Asn Pro Phe Ala 
            20                  25                  30          


Glu Tyr Met Trp Met Glu Asn Glu Glu Glu Phe Asn Arg Gln Ile Glu 
        35                  40                  45              


Glu Glu Leu Trp Glu Glu Glu Phe Ile Glu Arg Cys Phe Gln Glu Met 
    50                  55                  60                  


Leu Glu Glu Glu Glu Glu His Glu Trp Phe Ile Pro Ala Arg Asp Leu 
65                  70                  75                  80  


Pro Gln Thr Met Asp Gln Ile Gln Asp Gln Phe Asn Asp Leu Val Ile 
                85                  90                  95      


Ser Asp Gly Ser Ser Leu Glu Asp Leu Val Val Lys Ser Asn Leu Asn 
            100                 105                 110         


Pro Asn Ala Lys Glu Phe Val Pro Gly Val Lys Tyr Gly Asn Ile 
        115                 120                 125         


<210>  1178
<211>  1500
<212>  DNA
<213>  Homosapiens

<400>  1178
gtgaagtcac ttccgggctg gggtgtttgt ttggactgga gaagggaggc ggcgggcgaa     60

gcgcacgtcg agcgggggag cggcgctgcc tgtggagatc cgcggaggcc gacaggattc    120

gttggctgcc gtccccgctg ctgtgcattg ggttaaaaac gacaaccaac atcagccatg    180

aaagatccaa gtcgcagcag tactagccca agcatcatca atgaagatgt gattattaac    240

ggtcattctc atgaagatga caatccattt gcagagtaca tgtggatgga aaatgaagaa    300

gaattcaaca gacaaataga agaggagtta tgggaagaag aatttattga acgctgtttc    360

caagaaatgc tggaagagga agaagagcat gaatggttta ttccagctcg agatctccca    420

caaactatgg accaaatcca agaccagttt aatgaccttg ttatcagtga tggctcttct    480

ctggaagatc ttgtggtcaa gagcaatctg aatccaaatg caaaggagtt tgttcctggg    540

gtgaagtacg gaaatatttg agtagacggg gccctctttt ggtggatgta gcacaatttc    600

cacactgtga aggcagtatt agaagactta attgtaaaag ctctcttgtc actgtgttac    660

acttatgcat tgccaaagtt tttgttagtc ttgcatgctt aataaaagtg ctgagactgt    720

tactaagtaa aaagctgtca aacatttact gaaaatagaa ttggccccat ggcttgatgt    780

gaagacagca aggaaagaag caccagtcaa gttgtgaaca agcaccaaat taaaagacct    840

aaaccttacc aaattgtctt tttttgaggc taatctatca cttgttaatg tctaaacttt    900

aaaatcagta catttaattt gagttccaac tgttaagcat atttctcaga cttaaatttg    960

attatgtccc catcaaaaag aatctccatt ttctgaaggt ctgttagtta atttgagata   1020

atttgttaaa ggcaagtatg tcatattact gaggctacaa gttagtcagc agatgagtgc   1080

cagtccagcc ttttctggta tgttattgtt agaaatattg agttctaatg ttacatctga   1140

ggaagtatgt aatttgagaa ttgtaacttc taagggattc actgcatcat agctatgcct   1200

gtatggagtc taacatatga ccaataccaa cccataatcc agctgaacaa agatactgta   1260

acatgatttg agtggtgctt ttccttgctt tgttaaccat cacgagagtc tgcagcacaa   1320

cttttaacaa agctagaaca gttttggctt cttaaacttc atatttgggt aggttaagct   1380

gccatacgtg ttcagtgtga atagtgttta agttgaaaat attgtaaaaa aattatattt   1440

tttcaaaaat atttaaaaaa ataaataata gtagaactga gcaaaaaaaa aaaaaaaaaa   1500


<210>  1179
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  1179

Met Lys Asp Pro Ser Arg Ser Ser Thr Ser Pro Ser Ile Ile Asn Glu 
1               5                   10                  15      


Asp Val Ile Ile Asn Gly His Ser His Glu Asp Asp Asn Pro Phe Ala 
            20                  25                  30          


Glu Tyr Met Trp Met Glu Asn Glu Glu Glu Phe Asn Arg Gln Ile Glu 
        35                  40                  45              


Glu Glu Leu Trp Glu Glu Glu Phe Ile Glu Arg Cys Phe Gln Glu Met 
    50                  55                  60                  


Leu Glu Glu Glu Glu Glu His Glu Trp Phe Ile Pro Ala Arg Asp Leu 
65                  70                  75                  80  


Pro Gln Thr Met Asp Gln Ile Gln Asp Gln Phe Asn Asp Leu Val Ile 
                85                  90                  95      


Ser Asp Gly Ser Ser Leu Glu Asp Leu Val Val Lys Ser Asn Leu Asn 
            100                 105                 110         


Pro Asn Ala Lys Glu Phe Val Pro Gly Val Lys Tyr Gly Asn Ile 
        115                 120                 125         


<210>  1180
<211>  2326
<212>  DNA
<213>  Homosapiens

<400>  1180
ggcctttgtc aagtcatccc ctcttctcct caggaactgc tcaaacctgt gccccaaaga     60

tgagggccca ggaggacctc gagggccgga cacagcatga aaccaccagg gacccctcga    120

ccccgctacc cacagagcct aagtttgaca tgttgtacaa gatcgaggac gtgccacctt    180

ggtacctgtg catcctgctg ggcttccagc actacctgac atgcttcagt ggtaccatcg    240

ccgtgccctt cctgctggct gaggcgctgt gtgtgggcca cgaccagcac atggttagtc    300

agctcatcgg caccatcttc acgtgcgtgg gcatcaccac tctcatccag accaccgtgg    360

gcatccggct gccgctgttc caggccagtg cctttgcatt tctggttcca gccaaagcca    420

tactggctct ggagagatgg aaatgccccc cggaagagga gatctacggt aactggagtc    480

tgcccctgaa cacctctcat atttggcacc cacggatacg ggaggtccag ggtgcaatca    540

tggtgtccag cgtggtggag gtggtgattg gcctgctggg gctgcctggg gccctgctca    600

actacattgg gcctctcaca gtcaccccca ctgtctccct cattggcctt tctgtcttcc    660

aagctgctgg cgaccgagct ggctcccact ggggcatctc agcttgctcc attctcctga    720

tcatcctctt ctcccagtac ctgcgcaacc tcaccttcct gctgcctgtc taccgctggg    780

gcaagggcct cactctcctc cgcatccaga tcttcaaaat gtttcctatc atgctggcca    840

tcatgaccgt gtggctgctc tgctatgtcc tgaccttgac agacgtgctg cccacagacc    900

caaaagccta tggcttccag gcacgaaccg atgcccgtgg tgacatcatg gctattgcac    960

cctggatccg catcccctac ccctgtcagt ggggcctgcc cacggtgact gcggctgctg   1020

tcctgggaat gttcagcgcc actctggcag gcatcattga gtccatcgga gattactacg   1080

cctgtgcccg cctggctggt gcaccacccc ctccagtaca tgctatcaac aggggcatct   1140

tcaccgaagg catttgctgc atcatcgcgg ggctattggg cacgggcaac gggtccacct   1200

cgtccagtcc caacattggc gtcctgggaa ttaccaaggt gggcagccgg cgcgtggtgc   1260

agtatggtgc ggctatcatg ctggtcctgg gcaccatcgg caagttcacg gccctcttcg   1320

cctcgctccc tgaccccatc ctggggggca tgttctgcac tctctttggc atgattacag   1380

ctgtggggct gtccaacctg caatttgtgg acatgaactc ctctcgcaac ctcttcgtgc   1440

tgggattttc catgttcttc gggctcacgc tgcccaatta cctggagtcc aaccctggcg   1500

ccatcaatac aggcattctt gaagtggatc agattctgat tgtgctgctg accacggaga   1560

tgtttgtggg cgggtgcctt gctttcatac ttgacaacac agtgccaggg agcccagagg   1620

agcgtggtct gatacagtgg aaagctgggg ctcatgccaa cagtgacatg tcttccagcc   1680

tcaagagcta cgatttcccc attgggatgg gcatagtaaa aagaattacc tttctgaaat   1740

acattcctat ctgcccagtc ttcaaaggat tttcttcaag ttcaaaagat cagattgcaa   1800

ttccagaaga cactccagaa aatacagaaa ctgcatctgt gtgcaccaag gtctgaaaaa   1860

tgacttccag gaaaggaagc atggtatata acaggaaaag aaaactacat ggggaaccag   1920

aagacctaag cctgaaatcc cagccctgcc cctaactaac ttctgtgtaa actcagataa   1980

gtcacctttc tctgggattc aaatttttgc atcagttaaa aaaaaagggg tgggggggaa   2040

tgggccaaag tctgagtctt agagacttgt accaatgtta tgctatgtct ctaaatcttt   2100

actctcctaa gtagacttgt cagcatctag gaagaacagc tagaaatttt cctctgtgat   2160

attttagact gcaagttgaa aaaaataaaa agaaatgagg gcaggttcca gggcctgaaa   2220

tgtaggtatg ctgcaaggct tttacattga atttgaccct acatcacttc aagactaatg   2280

cataatatta aacatcatgt tgaagaaaaa aaaaaaaaaa aaaaaa                  2326


<210>  1181
<211>  598
<212>  PRT
<213>  Homosapiens

<400>  1181

Met Arg Ala Gln Glu Asp Leu Glu Gly Arg Thr Gln His Glu Thr Thr 
1               5                   10                  15      


Arg Asp Pro Ser Thr Pro Leu Pro Thr Glu Pro Lys Phe Asp Met Leu 
            20                  25                  30          


Tyr Lys Ile Glu Asp Val Pro Pro Trp Tyr Leu Cys Ile Leu Leu Gly 
        35                  40                  45              


Phe Gln His Tyr Leu Thr Cys Phe Ser Gly Thr Ile Ala Val Pro Phe 
    50                  55                  60                  


Leu Leu Ala Glu Ala Leu Cys Val Gly His Asp Gln His Met Val Ser 
65                  70                  75                  80  


Gln Leu Ile Gly Thr Ile Phe Thr Cys Val Gly Ile Thr Thr Leu Ile 
                85                  90                  95      


Gln Thr Thr Val Gly Ile Arg Leu Pro Leu Phe Gln Ala Ser Ala Phe 
            100                 105                 110         


Ala Phe Leu Val Pro Ala Lys Ala Ile Leu Ala Leu Glu Arg Trp Lys 
        115                 120                 125             


Cys Pro Pro Glu Glu Glu Ile Tyr Gly Asn Trp Ser Leu Pro Leu Asn 
    130                 135                 140                 


Thr Ser His Ile Trp His Pro Arg Ile Arg Glu Val Gln Gly Ala Ile 
145                 150                 155                 160 


Met Val Ser Ser Val Val Glu Val Val Ile Gly Leu Leu Gly Leu Pro 
                165                 170                 175     


Gly Ala Leu Leu Asn Tyr Ile Gly Pro Leu Thr Val Thr Pro Thr Val 
            180                 185                 190         


Ser Leu Ile Gly Leu Ser Val Phe Gln Ala Ala Gly Asp Arg Ala Gly 
        195                 200                 205             


Ser His Trp Gly Ile Ser Ala Cys Ser Ile Leu Leu Ile Ile Leu Phe 
    210                 215                 220                 


Ser Gln Tyr Leu Arg Asn Leu Thr Phe Leu Leu Pro Val Tyr Arg Trp 
225                 230                 235                 240 


Gly Lys Gly Leu Thr Leu Leu Arg Ile Gln Ile Phe Lys Met Phe Pro 
                245                 250                 255     


Ile Met Leu Ala Ile Met Thr Val Trp Leu Leu Cys Tyr Val Leu Thr 
            260                 265                 270         


Leu Thr Asp Val Leu Pro Thr Asp Pro Lys Ala Tyr Gly Phe Gln Ala 
        275                 280                 285             


Arg Thr Asp Ala Arg Gly Asp Ile Met Ala Ile Ala Pro Trp Ile Arg 
    290                 295                 300                 


Ile Pro Tyr Pro Cys Gln Trp Gly Leu Pro Thr Val Thr Ala Ala Ala 
305                 310                 315                 320 


Val Leu Gly Met Phe Ser Ala Thr Leu Ala Gly Ile Ile Glu Ser Ile 
                325                 330                 335     


Gly Asp Tyr Tyr Ala Cys Ala Arg Leu Ala Gly Ala Pro Pro Pro Pro 
            340                 345                 350         


Val His Ala Ile Asn Arg Gly Ile Phe Thr Glu Gly Ile Cys Cys Ile 
        355                 360                 365             


Ile Ala Gly Leu Leu Gly Thr Gly Asn Gly Ser Thr Ser Ser Ser Pro 
    370                 375                 380                 


Asn Ile Gly Val Leu Gly Ile Thr Lys Val Gly Ser Arg Arg Val Val 
385                 390                 395                 400 


Gln Tyr Gly Ala Ala Ile Met Leu Val Leu Gly Thr Ile Gly Lys Phe 
                405                 410                 415     


Thr Ala Leu Phe Ala Ser Leu Pro Asp Pro Ile Leu Gly Gly Met Phe 
            420                 425                 430         


Cys Thr Leu Phe Gly Met Ile Thr Ala Val Gly Leu Ser Asn Leu Gln 
        435                 440                 445             


Phe Val Asp Met Asn Ser Ser Arg Asn Leu Phe Val Leu Gly Phe Ser 
    450                 455                 460                 


Met Phe Phe Gly Leu Thr Leu Pro Asn Tyr Leu Glu Ser Asn Pro Gly 
465                 470                 475                 480 


Ala Ile Asn Thr Gly Ile Leu Glu Val Asp Gln Ile Leu Ile Val Leu 
                485                 490                 495     


Leu Thr Thr Glu Met Phe Val Gly Gly Cys Leu Ala Phe Ile Leu Asp 
            500                 505                 510         


Asn Thr Val Pro Gly Ser Pro Glu Glu Arg Gly Leu Ile Gln Trp Lys 
        515                 520                 525             


Ala Gly Ala His Ala Asn Ser Asp Met Ser Ser Ser Leu Lys Ser Tyr 
    530                 535                 540                 


Asp Phe Pro Ile Gly Met Gly Ile Val Lys Arg Ile Thr Phe Leu Lys 
545                 550                 555                 560 


Tyr Ile Pro Ile Cys Pro Val Phe Lys Gly Phe Ser Ser Ser Ser Lys 
                565                 570                 575     


Asp Gln Ile Ala Ile Pro Glu Asp Thr Pro Glu Asn Thr Glu Thr Ala 
            580                 585                 590         


Ser Val Cys Thr Lys Val 
        595             


<210>  1182
<211>  2338
<212>  DNA
<213>  Homosapiens

<400>  1182
ggcctttgtc aagtcatccc ctcttctcct caggaactgc tcaaacctgt gccccaaaga     60

tgagggccca ggaggacctc gagggccgga cacagcatga aaccaccagg gacccctcga    120

ccccgctacc cacagagcct aagtttgaca tgttgtacaa gatcgaggac gtgccacctt    180

ggtacctgtg catcctgctg ggcttccagc actacctgac atgcttcagt ggtaccatcg    240

ccgtgccctt cctgctggct gaggcgctgt gtgtgggcca cgaccagcac atggttagtc    300

agctcatcgg caccatcttc acgtgcgtgg gcatcaccac tctcatccag accaccgtgg    360

gcatccggct gccgctgttc caggccagtg cctttgcatt tctggttcca gccaaagcca    420

tactggctct ggagagatgg aaatgccccc cggaagagga gatctacggt aactggagtc    480

tgcccctgaa cacctctcat atttggcacc cacggatacg ggaggtgggt ttgcatgtcc    540

agggtgcaat catggtgtcc agcgtggtgg aggtggtgat tggcctgctg gggctgcctg    600

gggccctgct caactacatt gggcctctca cagtcacccc cactgtctcc ctcattggcc    660

tttctgtctt ccaagctgct ggcgaccgag ctggctccca ctggggcatc tcagcttgct    720

ccattctcct gatcatcctc ttctcccagt acctgcgcaa cctcaccttc ctgctgcctg    780

tctaccgctg gggcaagggc ctcactctcc tccgcatcca gatcttcaaa atgtttccta    840

tcatgctggc catcatgacc gtgtggctgc tctgctatgt cctgaccttg acagacgtgc    900

tgcccacaga cccaaaagcc tatggcttcc aggcacgaac cgatgcccgt ggtgacatca    960

tggctattgc accctggatc cgcatcccct acccctgtca gtggggcctg cccacggtga   1020

ctgcggctgc tgtcctggga atgttcagcg ccactctggc aggcatcatt gagtccatcg   1080

gagattacta cgcctgtgcc cgcctggctg gtgcaccacc ccctccagta catgctatca   1140

acaggggcat cttcaccgaa ggcatttgct gcatcatcgc ggggctattg ggcacgggca   1200

acgggtccac ctcgtccagt cccaacattg gcgtcctggg aattaccaag gtgggcagcc   1260

ggcgcgtggt gcagtatggt gcggctatca tgctggtcct gggcaccatc ggcaagttca   1320

cggccctctt cgcctcgctc cctgacccca tcctgggggg catgttctgc actctctttg   1380

gcatgattac agctgtgggg ctgtccaacc tgcaatttgt ggacatgaac tcctctcgca   1440

acctcttcgt gctgggattt tccatgttct tcgggctcac gctgcccaat tacctggagt   1500

ccaaccctgg cgccatcaat acaggcattc ttgaagtgga tcagattctg attgtgctgc   1560

tgaccacgga gatgtttgtg ggcgggtgcc ttgctttcat acttgacaac acagtgccag   1620

ggagcccaga ggagcgtggt ctgatacagt ggaaagctgg ggctcatgcc aacagtgaca   1680

tgtcttccag cctcaagagc tacgatttcc ccattgggat gggcatagta aaaagaatta   1740

cctttctgaa atacattcct atctgcccag tcttcaaagg attttcttca agttcaaaag   1800

atcagattgc aattccagaa gacactccag aaaatacaga aactgcatct gtgtgcacca   1860

aggtctgaaa aatgacttcc aggaaaggaa gcatggtata taacaggaaa agaaaactac   1920

atggggaacc agaagaccta agcctgaaat cccagccctg cccctaacta acttctgtgt   1980

aaactcagat aagtcacctt tctctgggat tcaaattttt gcatcagtta aaaaaaaagg   2040

ggtggggggg aatgggccaa agtctgagtc ttagagactt gtaccaatgt tatgctatgt   2100

ctctaaatct ttactctcct aagtagactt gtcagcatct aggaagaaca gctagaaatt   2160

ttcctctgtg atattttaga ctgcaagttg aaaaaaataa aaagaaatga gggcaggttc   2220

cagggcctga aatgtaggta tgctgcaagg cttttacatt gaatttgacc ctacatcact   2280

tcaagactaa tgcataatat taaacatcat gttgaagaaa aaaaaaaaaa aaaaaaaa     2338


<210>  1183
<211>  602
<212>  PRT
<213>  Homosapiens

<400>  1183

Met Arg Ala Gln Glu Asp Leu Glu Gly Arg Thr Gln His Glu Thr Thr 
1               5                   10                  15      


Arg Asp Pro Ser Thr Pro Leu Pro Thr Glu Pro Lys Phe Asp Met Leu 
            20                  25                  30          


Tyr Lys Ile Glu Asp Val Pro Pro Trp Tyr Leu Cys Ile Leu Leu Gly 
        35                  40                  45              


Phe Gln His Tyr Leu Thr Cys Phe Ser Gly Thr Ile Ala Val Pro Phe 
    50                  55                  60                  


Leu Leu Ala Glu Ala Leu Cys Val Gly His Asp Gln His Met Val Ser 
65                  70                  75                  80  


Gln Leu Ile Gly Thr Ile Phe Thr Cys Val Gly Ile Thr Thr Leu Ile 
                85                  90                  95      


Gln Thr Thr Val Gly Ile Arg Leu Pro Leu Phe Gln Ala Ser Ala Phe 
            100                 105                 110         


Ala Phe Leu Val Pro Ala Lys Ala Ile Leu Ala Leu Glu Arg Trp Lys 
        115                 120                 125             


Cys Pro Pro Glu Glu Glu Ile Tyr Gly Asn Trp Ser Leu Pro Leu Asn 
    130                 135                 140                 


Thr Ser His Ile Trp His Pro Arg Ile Arg Glu Val Gly Leu His Val 
145                 150                 155                 160 


Gln Gly Ala Ile Met Val Ser Ser Val Val Glu Val Val Ile Gly Leu 
                165                 170                 175     


Leu Gly Leu Pro Gly Ala Leu Leu Asn Tyr Ile Gly Pro Leu Thr Val 
            180                 185                 190         


Thr Pro Thr Val Ser Leu Ile Gly Leu Ser Val Phe Gln Ala Ala Gly 
        195                 200                 205             


Asp Arg Ala Gly Ser His Trp Gly Ile Ser Ala Cys Ser Ile Leu Leu 
    210                 215                 220                 


Ile Ile Leu Phe Ser Gln Tyr Leu Arg Asn Leu Thr Phe Leu Leu Pro 
225                 230                 235                 240 


Val Tyr Arg Trp Gly Lys Gly Leu Thr Leu Leu Arg Ile Gln Ile Phe 
                245                 250                 255     


Lys Met Phe Pro Ile Met Leu Ala Ile Met Thr Val Trp Leu Leu Cys 
            260                 265                 270         


Tyr Val Leu Thr Leu Thr Asp Val Leu Pro Thr Asp Pro Lys Ala Tyr 
        275                 280                 285             


Gly Phe Gln Ala Arg Thr Asp Ala Arg Gly Asp Ile Met Ala Ile Ala 
    290                 295                 300                 


Pro Trp Ile Arg Ile Pro Tyr Pro Cys Gln Trp Gly Leu Pro Thr Val 
305                 310                 315                 320 


Thr Ala Ala Ala Val Leu Gly Met Phe Ser Ala Thr Leu Ala Gly Ile 
                325                 330                 335     


Ile Glu Ser Ile Gly Asp Tyr Tyr Ala Cys Ala Arg Leu Ala Gly Ala 
            340                 345                 350         


Pro Pro Pro Pro Val His Ala Ile Asn Arg Gly Ile Phe Thr Glu Gly 
        355                 360                 365             


Ile Cys Cys Ile Ile Ala Gly Leu Leu Gly Thr Gly Asn Gly Ser Thr 
    370                 375                 380                 


Ser Ser Ser Pro Asn Ile Gly Val Leu Gly Ile Thr Lys Val Gly Ser 
385                 390                 395                 400 


Arg Arg Val Val Gln Tyr Gly Ala Ala Ile Met Leu Val Leu Gly Thr 
                405                 410                 415     


Ile Gly Lys Phe Thr Ala Leu Phe Ala Ser Leu Pro Asp Pro Ile Leu 
            420                 425                 430         


Gly Gly Met Phe Cys Thr Leu Phe Gly Met Ile Thr Ala Val Gly Leu 
        435                 440                 445             


Ser Asn Leu Gln Phe Val Asp Met Asn Ser Ser Arg Asn Leu Phe Val 
    450                 455                 460                 


Leu Gly Phe Ser Met Phe Phe Gly Leu Thr Leu Pro Asn Tyr Leu Glu 
465                 470                 475                 480 


Ser Asn Pro Gly Ala Ile Asn Thr Gly Ile Leu Glu Val Asp Gln Ile 
                485                 490                 495     


Leu Ile Val Leu Leu Thr Thr Glu Met Phe Val Gly Gly Cys Leu Ala 
            500                 505                 510         


Phe Ile Leu Asp Asn Thr Val Pro Gly Ser Pro Glu Glu Arg Gly Leu 
        515                 520                 525             


Ile Gln Trp Lys Ala Gly Ala His Ala Asn Ser Asp Met Ser Ser Ser 
    530                 535                 540                 


Leu Lys Ser Tyr Asp Phe Pro Ile Gly Met Gly Ile Val Lys Arg Ile 
545                 550                 555                 560 


Thr Phe Leu Lys Tyr Ile Pro Ile Cys Pro Val Phe Lys Gly Phe Ser 
                565                 570                 575     


Ser Ser Ser Lys Asp Gln Ile Ala Ile Pro Glu Asp Thr Pro Glu Asn 
            580                 585                 590         


Thr Glu Thr Ala Ser Val Cys Thr Lys Val 
        595                 600         


<210>  1184
<211>  988
<212>  DNA
<213>  Homosapiens

<400>  1184
gacacacaca tctgcacctc aaccacagac tacacttgct gaactggctc ctggggccat     60

gaggctgtca ctgccactgc tgctgctgct gctgggagcc tgggccatcc cagggggcct    120

cggggacagg gcgccactca cagccacagc cccacaactg gatgatgagg agatgtactc    180

agcccacatg cccgctcacc tgcgctgtga tgcctgcaga gctgtggctt accagagact    240

ctgctcctat cctccccacc ttccccctaa ctgagcagca gtcctgaggg ccctgcctcc    300

cagtccctcc ttgttccaga tgtggcaaaa tctggcaaag gcagagacca aacttcatac    360

ctcaaactct ggggggcggc gggagctgag cgagttgtct acacgatgtc ctggaccgga    420

gctgctcccg gaactggcag gactacggag ttcgagaagt ggaccaagtg aaacgtctca    480

caggcccagg acttagcgag gggccagagc caagcatcag cgtgatggtc acagggggcc    540

cctggcctac caggctctcc aggacatgtt tgcactactt ggggagtttg gagaagacca    600

gatctatgaa gcccaccaac aaggccgagg ggctctggag gcattgctat gtgggggacc    660

ccagggggcc tgctcagaga aggtgtcagc cacaagagaa gagctctagt cctggactct    720

accctcctct gaaagaagct ggggcttgct ctgacggtct ccactcccgt ctgcaggcag    780

ccaggagggc aggaagccct tgctctgtgc tgccatcctg cctccctcct ccagcctcag    840

ggcactcggg cctgggtggg agtcaacgcc ttcccctctg gactcaaata aaacccagtg    900

acctcacttc ttttctctgc aaaaggtgct tgtggggctg ggagtgcaga cattggtgtt    960

tctgctgatg tcccttgtga aaaaaaaa                                       988


<210>  1185
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  1185

Met Val Thr Gly Gly Pro Trp Pro Thr Arg Leu Ser Arg Thr Cys Leu 
1               5                   10                  15      


His Tyr Leu Gly Ser Leu Glu Lys Thr Arg Ser Met Lys Pro Thr Asn 
            20                  25                  30          


Lys Ala Glu Gly Leu Trp Arg His Cys Tyr Val Gly Asp Pro Arg Gly 
        35                  40                  45              


Pro Ala Gln Arg Arg Cys Gln Pro Gln Glu Lys Ser Ser Ser Pro Gly 
    50                  55                  60                  


Leu Tyr Pro Pro Leu Lys Glu Ala Gly Ala Cys Ser Asp Gly Leu His 
65                  70                  75                  80  


Ser Arg Leu Gln Ala Ala Arg Arg Ala Gly Ser Pro Cys Ser Val Leu 
                85                  90                  95      


Pro Ser Cys Leu Pro Pro Pro Ala Ser Gly His Ser Gly Leu Gly Gly 
            100                 105                 110         


Ser Gln Arg Leu Pro Leu Trp Thr Gln Ile Lys Pro Ser Asp Leu Thr 
        115                 120                 125             


Ser Phe Leu Cys Lys Arg Cys Leu Trp Gly Trp Glu Cys Arg His Trp 
    130                 135                 140                 


Cys Phe Cys 
145         


<210>  1186
<211>  2925
<212>  DNA
<213>  Homosapiens

<400>  1186
atgctgaccg cgctcgcccc gccagccctg cctgggatcc cgaggcagct gcccacggcc     60

cccgcgcggc gccaggactc ctccggttcg tcaggctcct actacacggc tccaggttct    120

ccggagcccc cggacgttgg gccggacgcg aaaggcccag cgaattggcc ctgggtggct    180

cctgggcggg gggcgggcgc gcagcctcgc ctgtccgtca gcgcccagaa tagccgccag    240

cggcacgggc ccggctcggg tttcccgcga ggcccaggtt ccggcccacg gccaccccag    300

ccccagctgc gcacgctgcc gtcgggggag atggaagtca tcttcggcgt cggacccctg    360

ttcggctgct ccggcgcaga cgatcgcgag gcgcaacaac agttcacgga gccggccttc    420

atcagcccct tgccgccggg gccagcgtct cccgccgcgg tcccacgcca gtcccaggtc    480

cccgatggtg gctcccgctg ggccacctac ctagagctgc ggccccgtgg gccaagtcct    540

gccgccccag cgcagttcga gtgtgtggag gtggctctgg aggagggcgc cgcgcccgcc    600

aggccccgga cagccgccgc gggcttcgtg cagacggcgt tggccagaaa actgagcccc    660

gaggccccgg ccccgagcag cgccaccttc gggtccacgg ggcggtcgga acctgagacc    720

cgggaaacgg cccgcagcac ccacgtggtc ctggagaagg ctaagtctcg gccacttcgc    780

gtacgagata attcggcccc cgccaaggcc ccgaggccgt ggcccagcct ccgcgagcgc    840

gcgattcggc gcgacaagcc tgcgcccggg acggagccgc tgggtcctgt tagttccagc    900

atcttccttc agtcagagga gaagatccag gaggcgcgga agactcggtt cccgcgagag    960

gcgccggatc gaactgttca gagggcacgg agtccgcctt ttgagtgtag gatcccctcg   1020

gaggttccga gtagggctgt gaggccaagg agcccgtccc cgccacggca gactccaaat   1080

ggggctgtac ggggtcctcg ctgcccgtcg ccccagaacc tgtccccgtg ggatcggact   1140

actcggaggg tgagtagccc attgttccct gaagcctcct ccgagtggga aaatcaaaat   1200

cctgccgtcg aggaaactgt cagcaggaga agcccttccc ctccgatcct ttcccagtgg   1260

aatcagtgtg ttgctgggga aaggagcccg tccctcgaag ccccttccct gtgggagatt   1320

ccacattcgg cagtcgcgga tgcggtggag ccacgtagca gcccgtcccc gccggccttc   1380

ttcccgtggg aggctccaga tcgtcctatt ggaacttggg gcccatctcc ccaagagaca   1440

tgggatccca tggggccggg ctcatcgata gcatttactc aggaagctca gaatgggtta   1500

actcaggagg agttggcacc gcctacaccg tccgcacccg gcactccaga accaacagag   1560

atgcagagtc catccacgcg ggaaatttca gatcttgcct ttggagggag tcagcagtcc   1620

ccagaggtag cagcacccga gccgcccggc agccaccctg tgggcaccct ggacgcggat   1680

aagtgcccgg aagtcttggg tcctggagag gcggcctcgg gacgcccgcg catggccatt   1740

ccgcggcctc gagacgtgcg caagttggtg aagaccacgt acgcgccagg cttcccggca   1800

ggagcacaag gctctgggct gcctgcgcct cctgccgacc cctgcgggga ggagggcggc   1860

gaatccaaga cgcaagagcc gccagcactg gggccccccg ccccggctca ctacacttcc   1920

gttttcatca aggattttct accggtggtg ccgcacccct acgagcctcc tgaaccgtcc   1980

ttcgacacgg tcgcccggga cgcctcacag cccaacgggg tcctgcggcg gagggcagag   2040

aacagcacgg cgaagccctt caagcgcaca gagatccgcc tgcctggggc cctggccttg   2100

ggtcgccggc ccgaggtaac ctcgcgagtg cgagcgcgcg gccctggagg agagaacagg   2160

gatgtagagg cccagcgcct ggtccccgac ggcgacggtc ggaccagccc tctaggcggc   2220

gcccgcagct catcccagcg ctcccccgta gggccagcag gggtccgatc gccccgcccc   2280

ggctcccctc agatgcaagc cagcccgagc cctgggatag cacccaaacc gaagacacca   2340

cctacggccc ccgagcccgc ggctgccgtc caggcgccac tcccgcggga gcccctggcg   2400

ttggcgggca ggacggcccc agcccagccc cgcgctgcct cggcgcctcc cacggaccgg   2460

tccccgcaaa gcccctccca gggagcgcgc aggcagcccg gggccgcgcc cctggggaag   2520

gtcttggtgg accccgagag cggccgctac tactttgtgg aggcgccgcg gcagcctcgg   2580

ctgcgggtgc tcttcgaccc tgagagtggg cagtacgtgg aggtgttgct gccgccctcg   2640

tctcccgggc cgccccaccg cgtctacacc cctctggccc tggggctcgg cctctacccg   2700

cccgcctatg ggcctatacc cagcctctct ctgccaccgt ccccgggccc gcaggccctc   2760

ggcagccccc agctaccctg ggtctctgag gcagggcccc tggacgggac ctactacctg   2820

ccggtgagcg ggacccccaa ccccgcacct cctctgctcc tctgtgcgcc gccctccagc   2880

tcaggtccca cccagcccgg caagggttca ttgttcccgc tgtga                   2925


<210>  1187
<211>  974
<212>  PRT
<213>  Homosapiens

<400>  1187

Met Leu Thr Ala Leu Ala Pro Pro Ala Leu Pro Gly Ile Pro Arg Gln 
1               5                   10                  15      


Leu Pro Thr Ala Pro Ala Arg Arg Gln Asp Ser Ser Gly Ser Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Thr Ala Pro Gly Ser Pro Glu Pro Pro Asp Val Gly Pro 
        35                  40                  45              


Asp Ala Lys Gly Pro Ala Asn Trp Pro Trp Val Ala Pro Gly Arg Gly 
    50                  55                  60                  


Ala Gly Ala Gln Pro Arg Leu Ser Val Ser Ala Gln Asn Ser Arg Gln 
65                  70                  75                  80  


Arg His Gly Pro Gly Ser Gly Phe Pro Arg Gly Pro Gly Ser Gly Pro 
                85                  90                  95      


Arg Pro Pro Gln Pro Gln Leu Arg Thr Leu Pro Ser Gly Glu Met Glu 
            100                 105                 110         


Val Ile Phe Gly Val Gly Pro Leu Phe Gly Cys Ser Gly Ala Asp Asp 
        115                 120                 125             


Arg Glu Ala Gln Gln Gln Phe Thr Glu Pro Ala Phe Ile Ser Pro Leu 
    130                 135                 140                 


Pro Pro Gly Pro Ala Ser Pro Ala Ala Val Pro Arg Gln Ser Gln Val 
145                 150                 155                 160 


Pro Asp Gly Gly Ser Arg Trp Ala Thr Tyr Leu Glu Leu Arg Pro Arg 
                165                 170                 175     


Gly Pro Ser Pro Ala Ala Pro Ala Gln Phe Glu Cys Val Glu Val Ala 
            180                 185                 190         


Leu Glu Glu Gly Ala Ala Pro Ala Arg Pro Arg Thr Ala Ala Ala Gly 
        195                 200                 205             


Phe Val Gln Thr Ala Leu Ala Arg Lys Leu Ser Pro Glu Ala Pro Ala 
    210                 215                 220                 


Pro Ser Ser Ala Thr Phe Gly Ser Thr Gly Arg Ser Glu Pro Glu Thr 
225                 230                 235                 240 


Arg Glu Thr Ala Arg Ser Thr His Val Val Leu Glu Lys Ala Lys Ser 
                245                 250                 255     


Arg Pro Leu Arg Val Arg Asp Asn Ser Ala Pro Ala Lys Ala Pro Arg 
            260                 265                 270         


Pro Trp Pro Ser Leu Arg Glu Arg Ala Ile Arg Arg Asp Lys Pro Ala 
        275                 280                 285             


Pro Gly Thr Glu Pro Leu Gly Pro Val Ser Ser Ser Ile Phe Leu Gln 
    290                 295                 300                 


Ser Glu Glu Lys Ile Gln Glu Ala Arg Lys Thr Arg Phe Pro Arg Glu 
305                 310                 315                 320 


Ala Pro Asp Arg Thr Val Gln Arg Ala Arg Ser Pro Pro Phe Glu Cys 
                325                 330                 335     


Arg Ile Pro Ser Glu Val Pro Ser Arg Ala Val Arg Pro Arg Ser Pro 
            340                 345                 350         


Ser Pro Pro Arg Gln Thr Pro Asn Gly Ala Val Arg Gly Pro Arg Cys 
        355                 360                 365             


Pro Ser Pro Gln Asn Leu Ser Pro Trp Asp Arg Thr Thr Arg Arg Val 
    370                 375                 380                 


Ser Ser Pro Leu Phe Pro Glu Ala Ser Ser Glu Trp Glu Asn Gln Asn 
385                 390                 395                 400 


Pro Ala Val Glu Glu Thr Val Ser Arg Arg Ser Pro Ser Pro Pro Ile 
                405                 410                 415     


Leu Ser Gln Trp Asn Gln Cys Val Ala Gly Glu Arg Ser Pro Ser Leu 
            420                 425                 430         


Glu Ala Pro Ser Leu Trp Glu Ile Pro His Ser Ala Val Ala Asp Ala 
        435                 440                 445             


Val Glu Pro Arg Ser Ser Pro Ser Pro Pro Ala Phe Phe Pro Trp Glu 
    450                 455                 460                 


Ala Pro Asp Arg Pro Ile Gly Thr Trp Gly Pro Ser Pro Gln Glu Thr 
465                 470                 475                 480 


Trp Asp Pro Met Gly Pro Gly Ser Ser Ile Ala Phe Thr Gln Glu Ala 
                485                 490                 495     


Gln Asn Gly Leu Thr Gln Glu Glu Leu Ala Pro Pro Thr Pro Ser Ala 
            500                 505                 510         


Pro Gly Thr Pro Glu Pro Thr Glu Met Gln Ser Pro Ser Thr Arg Glu 
        515                 520                 525             


Ile Ser Asp Leu Ala Phe Gly Gly Ser Gln Gln Ser Pro Glu Val Ala 
    530                 535                 540                 


Ala Pro Glu Pro Pro Gly Ser His Pro Val Gly Thr Leu Asp Ala Asp 
545                 550                 555                 560 


Lys Cys Pro Glu Val Leu Gly Pro Gly Glu Ala Ala Ser Gly Arg Pro 
                565                 570                 575     


Arg Met Ala Ile Pro Arg Pro Arg Asp Val Arg Lys Leu Val Lys Thr 
            580                 585                 590         


Thr Tyr Ala Pro Gly Phe Pro Ala Gly Ala Gln Gly Ser Gly Leu Pro 
        595                 600                 605             


Ala Pro Pro Ala Asp Pro Cys Gly Glu Glu Gly Gly Glu Ser Lys Thr 
    610                 615                 620                 


Gln Glu Pro Pro Ala Leu Gly Pro Pro Ala Pro Ala His Tyr Thr Ser 
625                 630                 635                 640 


Val Phe Ile Lys Asp Phe Leu Pro Val Val Pro His Pro Tyr Glu Pro 
                645                 650                 655     


Pro Glu Pro Ser Phe Asp Thr Val Ala Arg Asp Ala Ser Gln Pro Asn 
            660                 665                 670         


Gly Val Leu Arg Arg Arg Ala Glu Asn Ser Thr Ala Lys Pro Phe Lys 
        675                 680                 685             


Arg Thr Glu Ile Arg Leu Pro Gly Ala Leu Ala Leu Gly Arg Arg Pro 
    690                 695                 700                 


Glu Val Thr Ser Arg Val Arg Ala Arg Gly Pro Gly Gly Glu Asn Arg 
705                 710                 715                 720 


Asp Val Glu Ala Gln Arg Leu Val Pro Asp Gly Asp Gly Arg Thr Ser 
                725                 730                 735     


Pro Leu Gly Gly Ala Arg Ser Ser Ser Gln Arg Ser Pro Val Gly Pro 
            740                 745                 750         


Ala Gly Val Arg Ser Pro Arg Pro Gly Ser Pro Gln Met Gln Ala Ser 
        755                 760                 765             


Pro Ser Pro Gly Ile Ala Pro Lys Pro Lys Thr Pro Pro Thr Ala Pro 
    770                 775                 780                 


Glu Pro Ala Ala Ala Val Gln Ala Pro Leu Pro Arg Glu Pro Leu Ala 
785                 790                 795                 800 


Leu Ala Gly Arg Thr Ala Pro Ala Gln Pro Arg Ala Ala Ser Ala Pro 
                805                 810                 815     


Pro Thr Asp Arg Ser Pro Gln Ser Pro Ser Gln Gly Ala Arg Arg Gln 
            820                 825                 830         


Pro Gly Ala Ala Pro Leu Gly Lys Val Leu Val Asp Pro Glu Ser Gly 
        835                 840                 845             


Arg Tyr Tyr Phe Val Glu Ala Pro Arg Gln Pro Arg Leu Arg Val Leu 
    850                 855                 860                 


Phe Asp Pro Glu Ser Gly Gln Tyr Val Glu Val Leu Leu Pro Pro Ser 
865                 870                 875                 880 


Ser Pro Gly Pro Pro His Arg Val Tyr Thr Pro Leu Ala Leu Gly Leu 
                885                 890                 895     


Gly Leu Tyr Pro Pro Ala Tyr Gly Pro Ile Pro Ser Leu Ser Leu Pro 
            900                 905                 910         


Pro Ser Pro Gly Pro Gln Ala Leu Gly Ser Pro Gln Leu Pro Trp Val 
        915                 920                 925             


Ser Glu Ala Gly Pro Leu Asp Gly Thr Tyr Tyr Leu Pro Val Ser Gly 
    930                 935                 940                 


Thr Pro Asn Pro Ala Pro Pro Leu Leu Leu Cys Ala Pro Pro Ser Ser 
945                 950                 955                 960 


Ser Gly Pro Thr Gln Pro Gly Lys Gly Ser Leu Phe Pro Leu 
                965                 970                 


<210>  1188
<211>  649
<212>  DNA
<213>  Homosapiens

<400>  1188
gaagatggcg acgcccctcg ggtggtcgaa ggcggggtca ggatctgtgt gtctcgcttt     60

agatcaactg cgggacgtga ttgagtctca ggaggaacta atccaccagc tgaggaacgt    120

gatggttctc caggacgaaa attttgtcag taaagaagag ttccaggcag tggagaagaa    180

gctggtggaa gagaaagctg cccatgccaa aaccaaggtc ctcctggcca aggaagagga    240

gaagttacag tttgccctcg gagaggtaga ggtgctatcc aagcagctgg agaaagagaa    300

gctggccttt gaaaaagcgc tctccagtgt caagagcaaa gtccttcagg agtccagcaa    360

gaaggaccag ctcatcacca agtgcaatga gattgagtct cacattataa agcaagaaga    420

tatacttaat ggcaaagaga atgagattaa agagttgcag caagttatca gccagcagaa    480

acagatcttc aggaatcaca tgtctgactt ccggatccag aagcagcagg agagctacat    540

ggcccaggtg ctggaccaga agcataagaa agcctcaggg acacgtcagg cccgcagcca    600

ccagcatccc agggaaaaat aaaatggccg ccgctttcct gttctctgg                649


<210>  1189
<211>  205
<212>  PRT
<213>  Homosapiens

<400>  1189

Met Ala Thr Pro Leu Gly Trp Ser Lys Ala Gly Ser Gly Ser Val Cys 
1               5                   10                  15      


Leu Ala Leu Asp Gln Leu Arg Asp Val Ile Glu Ser Gln Glu Glu Leu 
            20                  25                  30          


Ile His Gln Leu Arg Asn Val Met Val Leu Gln Asp Glu Asn Phe Val 
        35                  40                  45              


Ser Lys Glu Glu Phe Gln Ala Val Glu Lys Lys Leu Val Glu Glu Lys 
    50                  55                  60                  


Ala Ala His Ala Lys Thr Lys Val Leu Leu Ala Lys Glu Glu Glu Lys 
65                  70                  75                  80  


Leu Gln Phe Ala Leu Gly Glu Val Glu Val Leu Ser Lys Gln Leu Glu 
                85                  90                  95      


Lys Glu Lys Leu Ala Phe Glu Lys Ala Leu Ser Ser Val Lys Ser Lys 
            100                 105                 110         


Val Leu Gln Glu Ser Ser Lys Lys Asp Gln Leu Ile Thr Lys Cys Asn 
        115                 120                 125             


Glu Ile Glu Ser His Ile Ile Lys Gln Glu Asp Ile Leu Asn Gly Lys 
    130                 135                 140                 


Glu Asn Glu Ile Lys Glu Leu Gln Gln Val Ile Ser Gln Gln Lys Gln 
145                 150                 155                 160 


Ile Phe Arg Asn His Met Ser Asp Phe Arg Ile Gln Lys Gln Gln Glu 
                165                 170                 175     


Ser Tyr Met Ala Gln Val Leu Asp Gln Lys His Lys Lys Ala Ser Gly 
            180                 185                 190         


Thr Arg Gln Ala Arg Ser His Gln His Pro Arg Glu Lys 
        195                 200                 205 


<210>  1190
<211>  657
<212>  DNA
<213>  Homosapiens

<400>  1190
actagctggc gggggcggaa gatggcgacg cccctcgggt ggtcgaaggc ggggtcagga     60

tctgtgtgtc tcgctttaga tcaactgcgg gacgtgattg agtctcagga ggaactaatc    120

caccagctga ggaacgtgat ggttctccag gacgaaaatt ttgtcagtaa agaagagttc    180

caggcagtgg agaagaagct ggtggaagag aaagctgccc atgccaaaac caaggtcctc    240

ctggccaagg aagaggagaa gttacagttt gccctcggag aggtagaggt gctatccaag    300

cagctggaga aagagaagct ggcctttgaa aaagcgctct ccagtgtcaa gagcaaagtc    360

cttcaggagt ccagcaagaa ggaccagctc atcaccaagt gcaatggtag gcgggaggcc    420

cgtgctctcc accacggtta tataaacggg ctctttccta accacccagt gcctgtgtca    480

aaggcagggt ttcactctaa cacctgtccc cagctgagga tacaggcagg cccgggtggg    540

ccacaccttc gaaaaggcct taagggacca ggcaggccac ggaaatgagg gaagcagtcg    600

gtgtactata ttcttcaccg ccataaagga atgggcttgc tcccattttt cctgaaa       657


<210>  1191
<211>  188
<212>  PRT
<213>  Homosapiens

<400>  1191

Met Ala Thr Pro Leu Gly Trp Ser Lys Ala Gly Ser Gly Ser Val Cys 
1               5                   10                  15      


Leu Ala Leu Asp Gln Leu Arg Asp Val Ile Glu Ser Gln Glu Glu Leu 
            20                  25                  30          


Ile His Gln Leu Arg Asn Val Met Val Leu Gln Asp Glu Asn Phe Val 
        35                  40                  45              


Ser Lys Glu Glu Phe Gln Ala Val Glu Lys Lys Leu Val Glu Glu Lys 
    50                  55                  60                  


Ala Ala His Ala Lys Thr Lys Val Leu Leu Ala Lys Glu Glu Glu Lys 
65                  70                  75                  80  


Leu Gln Phe Ala Leu Gly Glu Val Glu Val Leu Ser Lys Gln Leu Glu 
                85                  90                  95      


Lys Glu Lys Leu Ala Phe Glu Lys Ala Leu Ser Ser Val Lys Ser Lys 
            100                 105                 110         


Val Leu Gln Glu Ser Ser Lys Lys Asp Gln Leu Ile Thr Lys Cys Asn 
        115                 120                 125             


Gly Arg Arg Glu Ala Arg Ala Leu His His Gly Tyr Ile Asn Gly Leu 
    130                 135                 140                 


Phe Pro Asn His Pro Val Pro Val Ser Lys Ala Gly Phe His Ser Asn 
145                 150                 155                 160 


Thr Cys Pro Gln Leu Arg Ile Gln Ala Gly Pro Gly Gly Pro His Leu 
                165                 170                 175     


Arg Lys Gly Leu Lys Gly Pro Gly Arg Pro Arg Lys 
            180                 185             


<210>  1192
<211>  3019
<212>  DNA
<213>  Homosapiens

<400>  1192
aaagcggttg gcagcagcgg cgcttggagg aaaggaagcc ggttggaggg cgcagcgcac     60

ccctgctgcg cggaggaggg ggctgagctg aactcagcag aagttacatg cacaaggcaa    120

aaattctgac gttctcaaga gaccagctct gcccccgtgg ctcaactgac cctaccatgt    180

ggacgctgct cctccaggtg ggaactggag ttttgaaata aaatggatga tttgacgtta    240

cttgatcttc tggagtgccc tgtgtgcttt gagaagctcg atgtcacagc caaagtcctc    300

ccttgccagc acaccttctg caaaccatgt ctacagaggg ttttcaaggc ccacaaagag    360

ctgcggtgcc ccgaatgcag gacgcctgtg ttttccaaca ttgaggcgct gccggccaac    420

ctgctgctcg tgcgccttct ggatggagtg cgctcagggc agagctccgg gagagggggc    480

tccttccgca ggcctggcac gatgaccttg caggatggca ggaaaagcag gaccaacccc    540

agacgtctgc aggccagtcc tttccggcta gtgcctaatg tcagaatcca catggatggg    600

gtgcctcgag caaaggcctt atgcaactac agagggcaga atcccggtga cctaaggttt    660

aataagggag atatcatcct tctccggaga cagcttgatg agaattggta ccagggggaa    720

atcaatggca tcagcgggaa cttcccagcc agctccgtgg aagtcatcaa gcagctgccc    780

cagccgcccc cgctctgcag ggccctctac aacttcgacc tacgaggcaa ggacaagagt    840

gagaaccagg attgcctgac cttcctcaag gacgatatca tcactgtgat cagccgagtg    900

gatgagaact gggcagaagg caagttagga gataaagtag gcatcttccc tatcttgttt    960

gtagagccaa acctcaccgc aagacacctt ttagagaaga acaaaggtcg ccagtcatcc   1020

tgcacaaaaa acctgtccct ggtgtcctcg tcctccagag gcaacacgtc taccctccgt   1080

aggggcccag ggtccaggag gaaggtgcct gggcagtttt ccatcacaac agccttgaac   1140

actctcaacc ggatggtcca ttctccttca gggcgccata tggtagagat cagcacccca   1200

gtgctcatca gctccagcaa cccctctgtg atcacccagc ccatggagaa agcagacgtt   1260

ccttccagct gtgtgggaca ggtcagcact tatcaccccg cacctgtctc tccaggacat   1320

tccacagccg tggtcagtct gcctggctcc cagcaacacc tctcagcgaa catgtttgta   1380

gccctgcact cctactcagc ccatggaccc gatgagctgg acctgcaaaa gggagaaggc   1440

gtcagggtcc tggggaagtg ccaggacggc tggctcaggg gcgtctcctt ggtcaccggg   1500

cgagtcggca tcttcccaaa caattacgtc atccccattt tcagaaagac ctctagtttt   1560

ccagactccc ggagccctgg tctctacacc acatggacgt tatccacctc ctctgtgtcc   1620

tcccaaggca gcatttcaga aggtgatcca cggcaaagcc gtcccttcaa atccgtcttt   1680

gtgcccactg ccatagtcaa ccccgtgaga agcacagccg gccctgggac tttaggacaa   1740

gggtctcttc ggaaagggcg gagcagcatg agaaagaatg gatccctgca gagacccctc   1800

cagtccggga tccccactct cgtggtaggc tccctcagac gcagccccac catggtcctt   1860

cggcctcagc agttccaatt ctaccagcca caggggatcc cctcctcccc ctcagccgtg   1920

gtggtggaga tggggtccaa gcctgccctc acgggggagc ccgccctcac gtgcatcagc   1980

aggggcagtg aggcccggat ccactccgcg gccagctccc tcattatgga agacaaagaa   2040

atccccatca agagtgagcc tctgccaaaa ccgcccgcat ctgccccacc atccatcctg   2100

gtgaaaccag aaaactcaag aaatggcatc gaaaagcaag tcaaaaccgt gagatttcag   2160

aattacagcc ctcctcccac caaacattac acctcccatc ccacctccgg aaagcctgaa   2220

cagccagcca ccctcaaggc gtcccagcct gaagcagcgt ccttgggccc agagatgacc   2280

gtcctatttg cccaccgaag tggctgccac tccggacagc agacagacct ccggagaaag   2340

tcagctcttg ccaaggccac aaccctggtg tccactgcct caggcacgca gaccgtgttt   2400

cccagcaaat gaacctacgg gtggcttttc ctagacccca aagaggtgaa ttgcatttaa   2460

atacagtctg cctccactga gggcatcctg ccattctttg gggacttgag catgggtcct   2520

tgttcttcct atttcacctc caggaaagca aaagtgggag cagaaattcc tgccctgggt   2580

gggaggatag atggcgtggc cttccaaaca tacaaacata atgatttgat gccacaaagc   2640

tcgcttactc agaccaagga gtgaaaaatt gtcgtgccca ctttatgccc cagcatggag   2700

tatgtggcct cttgtcatcc ccgtgttact gtgtagaatt tctatggtgt cctaaagggg   2760

gctgcagcag gggtgtgaca acggtgggat tgttggcgtt gcttctttga ccttacaata   2820

tcctcaacaa gcattagaac aacttctgcc atcttctggg gcctgtacac tggccactag   2880

tagctgccat atctttttcc ctctgtaaag tcataatcct ggctgcaaag ggaggatttc   2940

tgcgcggggt gtgaggtgga tactttgaac attctgagaa cccaataaaa ctagaaggag   3000

ccaaaaaaaa aaaaaaaaa                                                3019


<210>  1193
<211>  729
<212>  PRT
<213>  Homosapiens

<400>  1193

Met Asp Asp Leu Thr Leu Leu Asp Leu Leu Glu Cys Pro Val Cys Phe 
1               5                   10                  15      


Glu Lys Leu Asp Val Thr Ala Lys Val Leu Pro Cys Gln His Thr Phe 
            20                  25                  30          


Cys Lys Pro Cys Leu Gln Arg Val Phe Lys Ala His Lys Glu Leu Arg 
        35                  40                  45              


Cys Pro Glu Cys Arg Thr Pro Val Phe Ser Asn Ile Glu Ala Leu Pro 
    50                  55                  60                  


Ala Asn Leu Leu Leu Val Arg Leu Leu Asp Gly Val Arg Ser Gly Gln 
65                  70                  75                  80  


Ser Ser Gly Arg Gly Gly Ser Phe Arg Arg Pro Gly Thr Met Thr Leu 
                85                  90                  95      


Gln Asp Gly Arg Lys Ser Arg Thr Asn Pro Arg Arg Leu Gln Ala Ser 
            100                 105                 110         


Pro Phe Arg Leu Val Pro Asn Val Arg Ile His Met Asp Gly Val Pro 
        115                 120                 125             


Arg Ala Lys Ala Leu Cys Asn Tyr Arg Gly Gln Asn Pro Gly Asp Leu 
    130                 135                 140                 


Arg Phe Asn Lys Gly Asp Ile Ile Leu Leu Arg Arg Gln Leu Asp Glu 
145                 150                 155                 160 


Asn Trp Tyr Gln Gly Glu Ile Asn Gly Ile Ser Gly Asn Phe Pro Ala 
                165                 170                 175     


Ser Ser Val Glu Val Ile Lys Gln Leu Pro Gln Pro Pro Pro Leu Cys 
            180                 185                 190         


Arg Ala Leu Tyr Asn Phe Asp Leu Arg Gly Lys Asp Lys Ser Glu Asn 
        195                 200                 205             


Gln Asp Cys Leu Thr Phe Leu Lys Asp Asp Ile Ile Thr Val Ile Ser 
    210                 215                 220                 


Arg Val Asp Glu Asn Trp Ala Glu Gly Lys Leu Gly Asp Lys Val Gly 
225                 230                 235                 240 


Ile Phe Pro Ile Leu Phe Val Glu Pro Asn Leu Thr Ala Arg His Leu 
                245                 250                 255     


Leu Glu Lys Asn Lys Gly Arg Gln Ser Ser Cys Thr Lys Asn Leu Ser 
            260                 265                 270         


Leu Val Ser Ser Ser Ser Arg Gly Asn Thr Ser Thr Leu Arg Arg Gly 
        275                 280                 285             


Pro Gly Ser Arg Arg Lys Val Pro Gly Gln Phe Ser Ile Thr Thr Ala 
    290                 295                 300                 


Leu Asn Thr Leu Asn Arg Met Val His Ser Pro Ser Gly Arg His Met 
305                 310                 315                 320 


Val Glu Ile Ser Thr Pro Val Leu Ile Ser Ser Ser Asn Pro Ser Val 
                325                 330                 335     


Ile Thr Gln Pro Met Glu Lys Ala Asp Val Pro Ser Ser Cys Val Gly 
            340                 345                 350         


Gln Val Ser Thr Tyr His Pro Ala Pro Val Ser Pro Gly His Ser Thr 
        355                 360                 365             


Ala Val Val Ser Leu Pro Gly Ser Gln Gln His Leu Ser Ala Asn Met 
    370                 375                 380                 


Phe Val Ala Leu His Ser Tyr Ser Ala His Gly Pro Asp Glu Leu Asp 
385                 390                 395                 400 


Leu Gln Lys Gly Glu Gly Val Arg Val Leu Gly Lys Cys Gln Asp Gly 
                405                 410                 415     


Trp Leu Arg Gly Val Ser Leu Val Thr Gly Arg Val Gly Ile Phe Pro 
            420                 425                 430         


Asn Asn Tyr Val Ile Pro Ile Phe Arg Lys Thr Ser Ser Phe Pro Asp 
        435                 440                 445             


Ser Arg Ser Pro Gly Leu Tyr Thr Thr Trp Thr Leu Ser Thr Ser Ser 
    450                 455                 460                 


Val Ser Ser Gln Gly Ser Ile Ser Glu Gly Asp Pro Arg Gln Ser Arg 
465                 470                 475                 480 


Pro Phe Lys Ser Val Phe Val Pro Thr Ala Ile Val Asn Pro Val Arg 
                485                 490                 495     


Ser Thr Ala Gly Pro Gly Thr Leu Gly Gln Gly Ser Leu Arg Lys Gly 
            500                 505                 510         


Arg Ser Ser Met Arg Lys Asn Gly Ser Leu Gln Arg Pro Leu Gln Ser 
        515                 520                 525             


Gly Ile Pro Thr Leu Val Val Gly Ser Leu Arg Arg Ser Pro Thr Met 
    530                 535                 540                 


Val Leu Arg Pro Gln Gln Phe Gln Phe Tyr Gln Pro Gln Gly Ile Pro 
545                 550                 555                 560 


Ser Ser Pro Ser Ala Val Val Val Glu Met Gly Ser Lys Pro Ala Leu 
                565                 570                 575     


Thr Gly Glu Pro Ala Leu Thr Cys Ile Ser Arg Gly Ser Glu Ala Arg 
            580                 585                 590         


Ile His Ser Ala Ala Ser Ser Leu Ile Met Glu Asp Lys Glu Ile Pro 
        595                 600                 605             


Ile Lys Ser Glu Pro Leu Pro Lys Pro Pro Ala Ser Ala Pro Pro Ser 
    610                 615                 620                 


Ile Leu Val Lys Pro Glu Asn Ser Arg Asn Gly Ile Glu Lys Gln Val 
625                 630                 635                 640 


Lys Thr Val Arg Phe Gln Asn Tyr Ser Pro Pro Pro Thr Lys His Tyr 
                645                 650                 655     


Thr Ser His Pro Thr Ser Gly Lys Pro Glu Gln Pro Ala Thr Leu Lys 
            660                 665                 670         


Ala Ser Gln Pro Glu Ala Ala Ser Leu Gly Pro Glu Met Thr Val Leu 
        675                 680                 685             


Phe Ala His Arg Ser Gly Cys His Ser Gly Gln Gln Thr Asp Leu Arg 
    690                 695                 700                 


Arg Lys Ser Ala Leu Ala Lys Ala Thr Thr Leu Val Ser Thr Ala Ser 
705                 710                 715                 720 


Gly Thr Gln Thr Val Phe Pro Ser Lys 
                725                 


<210>  1194
<211>  725
<212>  DNA
<213>  Homosapiens

<400>  1194
ccgaagttta gaaaccagct tattgccaaa gggaaaaagg atagcccaaa ggacaagaaa     60

acacttctca ctatgaattg gtttggaagt aacttcttca ggtgtcctga ggatctttcc    120

ttactcaaca tatactcacc tctgttgtca cacatgtcat ctgaagatga acattttatt    180

tccaacttga gaggccatgt accagccagc gctgtggtga agcagcctgt tcggggagcc    240

agtggcagga cgacaatcac agcaattgtc cagactggcg ggggctggag caccggtctc    300

ttcagtgtct gcagagatag gagaatttgt ttctgtggtc tattctgtcc tatgtgtctt    360

gagtgtgaca tcgccaggca ttatggagag tgtctttgtt ggccgttgtt acctgggtcc    420

acctttgcac tgagaattgg caccagggag agacataaaa tacagggcac actgtgtgaa    480

gactggctgg cggtgcactg ctgttgggct ttttccatct gccaggtggc ccgggaactc    540

aagatgagga cctcccaagt ctatgaaatc tgtgcagtcc caatgactaa ggacaccctg    600

gtttgacagc aagataactc ctcctcctta ctccccaaca ccctcctctc aaacctctca    660

gtggaacaat tgctttttcc taagttttta ctgaaatggt atgaaaataa atgatttccc    720

cccta                                                                725


<210>  1195
<211>  177
<212>  PRT
<213>  Homosapiens

<400>  1195

Met Asn Trp Phe Gly Ser Asn Phe Phe Arg Cys Pro Glu Asp Leu Ser 
1               5                   10                  15      


Leu Leu Asn Ile Tyr Ser Pro Leu Leu Ser His Met Ser Ser Glu Asp 
            20                  25                  30          


Glu His Phe Ile Ser Asn Leu Arg Gly His Val Pro Ala Ser Ala Val 
        35                  40                  45              


Val Lys Gln Pro Val Arg Gly Ala Ser Gly Arg Thr Thr Ile Thr Ala 
    50                  55                  60                  


Ile Val Gln Thr Gly Gly Gly Trp Ser Thr Gly Leu Phe Ser Val Cys 
65                  70                  75                  80  


Arg Asp Arg Arg Ile Cys Phe Cys Gly Leu Phe Cys Pro Met Cys Leu 
                85                  90                  95      


Glu Cys Asp Ile Ala Arg His Tyr Gly Glu Cys Leu Cys Trp Pro Leu 
            100                 105                 110         


Leu Pro Gly Ser Thr Phe Ala Leu Arg Ile Gly Thr Arg Glu Arg His 
        115                 120                 125             


Lys Ile Gln Gly Thr Leu Cys Glu Asp Trp Leu Ala Val His Cys Cys 
    130                 135                 140                 


Trp Ala Phe Ser Ile Cys Gln Val Ala Arg Glu Leu Lys Met Arg Thr 
145                 150                 155                 160 


Ser Gln Val Tyr Glu Ile Cys Ala Val Pro Met Thr Lys Asp Thr Leu 
                165                 170                 175     


Val 
    


<210>  1196
<211>  4868
<212>  DNA
<213>  Homosapiens

<400>  1196
agttagcgcc tgctgggtgt ctgctcgggt ggtctgggaa ctacaattcc cggcgggctg     60

tgagatgcct tggctgtagt tagtaaggag ccggatgatt gcctcagcag gtgtgaagcg    120

tgtgctttag tttcgtggga ggcctggcat ccccgagagg gaggggaaag gtaaccactc    180

ctttgtggag gtcgccaggg tcattgtcgt ggatttgcac agtcggctgg gcggtgcaat    240

ggcggaaaga aaaggaacag ccaaagtgga ctttttgaag aagattgaga aagaaatcca    300

acagaaatgg gatactgaga gagtgtttga ggtcaatgca tctaatttag agaaacagac    360

cagcaagggc aagtattttg taaccttccc atatccatat atgaatggac gccttcattt    420

gggacacacg ttttctttat ccaaatgtga gtttgctgta gggtaccagc gattgaaagg    480

aaaatgttgt ctgtttccct ttggcctgca ctgtactgga atgcctatta aggcatgtgc    540

tgataagttg aaaagagaaa tagagctgta tggttgcccc cctgattttc cagatgaaga    600

agaggaagag gaagaaacca gtgttaaaac agaagatata ataattaagg ataaagctaa    660

aggaaaaaag agtaaagctg ctgctaaagc tggatcttct aaataccagt ggggcattat    720

gaaatccctt ggcctgtctg atgaagagat agtaaaattt tctgaagcag aacattggct    780

tgattatttc ccgccactgg ctattcagga tttaaaaaga atgggtttga aggtagactg    840

gcgtcgttcc ttcatcacca ctgatgttaa tccttactat gattcatttg tcagatggca    900

atttttaaca ttaagagaaa gaaacaaaat taaatttggg aagcggtata caatttactc    960

tccgaaagat ggacagcctt gcatggatca tgatagacaa actggagagg gtgttggacc   1020

tcaggaatat actttactca aattgaaggt gcttgagcca tacccatcta aattaagtgg   1080

cctgaaaggt aaaaatattt tcttggtggc tgctactctc agacctgaga ccatgtttgg   1140

gcagacaaat tgttgggttc gtcctgatat gaagtacatt ggatttgaga cggtgaatgg   1200

tgatatattc atctgtaccc aaaaagcagc caggaatatg tcataccagg gctttaccaa   1260

agacaatggc gtggtgcctg ttgttaagga attaatgggg gaggaaattc ttggtgcatc   1320

actttctgca cctttaacat catacaaggt gatctatgtt ctcccaatgc taactattaa   1380

ggaggataaa ggcactggtg tggttacaag tgttccttcc gactcccctg atgatattgc   1440

tgccctcaga gacttgaaga aaaagcaagc cttacgagca aaatatggaa ttagagatga   1500

catggtcttg ccatttgagc cggtgccagt cattgaaatc ccaggttttg gaaatctttc   1560

tgctgtaacc atttgtgatg agttgaaaat tcagagccag aatgaccggg aaaaacttgc   1620

agaagcaaag gagaagatat atctaaaagg attttatgag ggtatcatgt tggtggatgg   1680

atttaaagga cagaaggttc aagatgtaaa gaagactatt cagaaaaaga tgattgacgc   1740

tggagatgca cttatttaca tggaaccaga gaaacaagtg atgtccaggt cgtcagatga   1800

atgtgttgtg gctctgtgtg accagtggta cttggattat ggagaagaga attggaagaa   1860

acagacatct cagtgcttga agaacctgga aacattctgt gaggagacca ggaggaattt   1920

tgaagccacc ttaggttggc tacaagaaca tgcttgctca agaacttatg gtctaggcac   1980

tcacctgcct tgggatgagc agtggctgat tgaatcactt tctgactcca ctatttacat   2040

ggcattttac acagttgcac acctattgca ggggggtaac ttgcatggac aggcagagtc   2100

tccgctgggc attagaccgc aacagatgac caaggaagtt tgggattatg ttttcttcaa   2160

ggaggctcca tttcctaaga ctcagattgc aaaggaaaaa ttagatcagt taaagcagga   2220

gtttgaattc tggtatcctg ttgatcttcg cgtctctggc aaggatcttg ttccaaatca   2280

tctttcatat tacctttata atcatgtggc tatgtggccg gaacaaagtg acaaatggcc   2340

tacagctgtg agagcaaatg gacatctcct cctgaactct gagaagatgt caaaatccac   2400

aggcaacttc ctcactttga cccaagctat tgacaaattt tcagcagatg gaatgcgttt   2460

ggctctggct gatgctggtg acactgtaga agatgccaac tttgtggaag ccatggcaga   2520

tgcaggtatt ctccgtctgt acacctgggt agagtgggtg aaagaaatgg ttgccaactg   2580

ggacagccta agaagtggtc ctgccagcac tttcaatgat agagtttttg ccagtgaatt   2640

gaatgcagga attataaaaa cagatcaaaa ctatgaaaag atgatgttta aagaagcttt   2700

gaaaacaggg ttttttgagt ttcaggccgc aaaagataag taccgtgaat tggctgtgga   2760

agggatgcac agagaacttg tgttccggtt tattgaagtt cagacacttc tcctcgctcc   2820

attctgtcca catttgtgtg agcacatctg gacactcctg ggaaagcctg actcaattat   2880

gaatgcttca tggcctgtgg caggtcctgt taatgaagtt ttaatacact cctcacagta   2940

tcttatggaa gtaacacatg accttagact acgactcaag aactatatga tgccagctaa   3000

agggaagaag actgacaaac aacccctgca gaagccctca cattgcacca tctatgtggc   3060

aaagaactat ccaccttggc aacataccac cctgtctgtt ctacgtaaac actttgaggc   3120

caataacgga aaactgcctg acaacaaagt cattgctagt gaactaggca gtatgccaga   3180

actgaagaaa tacatgaaga aagtcatgcc atttgttgcc atgattaagg aaaatctgga   3240

gaagatgggg cctcgtattc tggatttgca attagaattt gatgaaaagg ctgtgcttat   3300

ggagaatata gtctatctga ctaattcgct tgagctagaa cacatagaag tcaagtttgc   3360

ctccgaagca gaagataaaa tcagggaaga ctgctgtcct gggaaaccac ttaatgtttt   3420

tagaatagaa cctggtgtgt ccgtttctct ggtgaatccc cagccatcca atggccactt   3480

ctcaaccaaa attgaaatca ggcaaggaga taactgtgat tccataatca ggcgtttaat   3540

gaaaatgaat cgaggaatta aagacctttc caaagtgaaa ctgatgagat ttgatgatcc   3600

actgttgggg cctcgacgag ttcctgtcct gggaaaggag tacaccgaga agacccccat   3660

ttctgagcat gctgttttca atgtggacct catgagcaag aaaattcatc tgactgagaa   3720

tgggataagg gtggatattg gcgatacaat aatctatctg gttcattaaa ctcatgcaca   3780

ttggagattt atcctggttt cttaggaata ctactactct gattgtgtct actgattggc   3840

tatcagaacc ttaggctgga cctaaataga ttgatttcat ttctaaccat ccaattctgc   3900

atgtattcat aattctatca agtcatcttt gattcctgga cctaataaat tttttttccc   3960

tttctttggg tgtccaagag aaatggtttt tgccaaactc tttttaaaaa acaaattgtt   4020

gctatttcct agaagtttct ggtttttaag atgaacataa aagtgtcagt atgcttcttt   4080

tatgaggtgt actttatact ttgatgaagg ctaaggtgta cctaacagct ttttatagta   4140

tattcattta tggagttagc tgtatttttt tttaaaaaag aaaagtagta aattagcagc   4200

tttttttttt aaatgaagag aacttcatga tgatttaaaa gaactaatga gaatattttg   4260

acttgacttc aattactaag tattttgtat aaagaacaaa taggtcctgc attttataag   4320

actttttaaa gctttaatta ttcaactaag aaccaataat ggcttcttca aggctaatat   4380

caatagttta taagcagtat atttcaccta cactaaatat gggcatttta aaagaagatt   4440

ccccccttcc cccccagaaa tctgcattta ctaaatttgt cttaagtcca attgtgttta   4500

aaggtcatgc tggtcgggtg tggtggctca cacctataat cccagcactt tgggaggcca   4560

aggtgggcag tcacctgagg tcaggagttt gagaccagcc tgaccaacat ggtgaaaccc   4620

cgtctctact aaaaatacaa aaattagctt ggcatggtgg cgggtacctg taatcccagc   4680

tgcttgggag tgtgaggcag gagaatcgct tgaacctggg agaccgaggt tgcagtgagc   4740

tgaaaccgtg ccattgcact ccagcttagg caacaagagt gaaactctgt ctcaatcaat   4800

ccatcaatca atcaataaaa tagaggtcat gctgactatt acagatttaa aaaaaaaaaa   4860

aaaaaaaa                                                            4868


<210>  1197
<211>  1176
<212>  PRT
<213>  Homosapiens

<400>  1197

Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile 
1               5                   10                  15      


Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val 
            20                  25                  30          


Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val 
        35                  40                  45              


Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr 
    50                  55                  60                  


Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys 
65                  70                  75                  80  


Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro 
                85                  90                  95      


Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly 
            100                 105                 110         


Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser 
        115                 120                 125             


Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys 
    130                 135                 140                 


Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile 
145                 150                 155                 160 


Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu 
                165                 170                 175     


Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu 
            180                 185                 190         


Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr 
        195                 200                 205             


Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr 
    210                 215                 220                 


Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr 
225                 230                 235                 240 


Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly 
                245                 250                 255     


Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu 
            260                 265                 270         


Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe 
        275                 280                 285             


Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn 
    290                 295                 300                 


Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn 
305                 310                 315                 320 


Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr 
                325                 330                 335     


Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu 
            340                 345                 350         


Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser 
        355                 360                 365             


Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile Lys Glu Asp Lys 
    370                 375                 380                 


Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser Pro Asp Asp Ile 
385                 390                 395                 400 


Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Ala Leu Arg Ala Lys Tyr 
                405                 410                 415     


Gly Ile Arg Asp Asp Met Val Leu Pro Phe Glu Pro Val Pro Val Ile 
            420                 425                 430         


Glu Ile Pro Gly Phe Gly Asn Leu Ser Ala Val Thr Ile Cys Asp Glu 
        435                 440                 445             


Leu Lys Ile Gln Ser Gln Asn Asp Arg Glu Lys Leu Ala Glu Ala Lys 
    450                 455                 460                 


Glu Lys Ile Tyr Leu Lys Gly Phe Tyr Glu Gly Ile Met Leu Val Asp 
465                 470                 475                 480 


Gly Phe Lys Gly Gln Lys Val Gln Asp Val Lys Lys Thr Ile Gln Lys 
                485                 490                 495     


Lys Met Ile Asp Ala Gly Asp Ala Leu Ile Tyr Met Glu Pro Glu Lys 
            500                 505                 510         


Gln Val Met Ser Arg Ser Ser Asp Glu Cys Val Val Ala Leu Cys Asp 
        515                 520                 525             


Gln Trp Tyr Leu Asp Tyr Gly Glu Glu Asn Trp Lys Lys Gln Thr Ser 
    530                 535                 540                 


Gln Cys Leu Lys Asn Leu Glu Thr Phe Cys Glu Glu Thr Arg Arg Asn 
545                 550                 555                 560 


Phe Glu Ala Thr Leu Gly Trp Leu Gln Glu His Ala Cys Ser Arg Thr 
                565                 570                 575     


Tyr Gly Leu Gly Thr His Leu Pro Trp Asp Glu Gln Trp Leu Ile Glu 
            580                 585                 590         


Ser Leu Ser Asp Ser Thr Ile Tyr Met Ala Phe Tyr Thr Val Ala His 
        595                 600                 605             


Leu Leu Gln Gly Gly Asn Leu His Gly Gln Ala Glu Ser Pro Leu Gly 
    610                 615                 620                 


Ile Arg Pro Gln Gln Met Thr Lys Glu Val Trp Asp Tyr Val Phe Phe 
625                 630                 635                 640 


Lys Glu Ala Pro Phe Pro Lys Thr Gln Ile Ala Lys Glu Lys Leu Asp 
                645                 650                 655     


Gln Leu Lys Gln Glu Phe Glu Phe Trp Tyr Pro Val Asp Leu Arg Val 
            660                 665                 670         


Ser Gly Lys Asp Leu Val Pro Asn His Leu Ser Tyr Tyr Leu Tyr Asn 
        675                 680                 685             


His Val Ala Met Trp Pro Glu Gln Ser Asp Lys Trp Pro Thr Ala Val 
    690                 695                 700                 


Arg Ala Asn Gly His Leu Leu Leu Asn Ser Glu Lys Met Ser Lys Ser 
705                 710                 715                 720 


Thr Gly Asn Phe Leu Thr Leu Thr Gln Ala Ile Asp Lys Phe Ser Ala 
                725                 730                 735     


Asp Gly Met Arg Leu Ala Leu Ala Asp Ala Gly Asp Thr Val Glu Asp 
            740                 745                 750         


Ala Asn Phe Val Glu Ala Met Ala Asp Ala Gly Ile Leu Arg Leu Tyr 
        755                 760                 765             


Thr Trp Val Glu Trp Val Lys Glu Met Val Ala Asn Trp Asp Ser Leu 
    770                 775                 780                 


Arg Ser Gly Pro Ala Ser Thr Phe Asn Asp Arg Val Phe Ala Ser Glu 
785                 790                 795                 800 


Leu Asn Ala Gly Ile Ile Lys Thr Asp Gln Asn Tyr Glu Lys Met Met 
                805                 810                 815     


Phe Lys Glu Ala Leu Lys Thr Gly Phe Phe Glu Phe Gln Ala Ala Lys 
            820                 825                 830         


Asp Lys Tyr Arg Glu Leu Ala Val Glu Gly Met His Arg Glu Leu Val 
        835                 840                 845             


Phe Arg Phe Ile Glu Val Gln Thr Leu Leu Leu Ala Pro Phe Cys Pro 
    850                 855                 860                 


His Leu Cys Glu His Ile Trp Thr Leu Leu Gly Lys Pro Asp Ser Ile 
865                 870                 875                 880 


Met Asn Ala Ser Trp Pro Val Ala Gly Pro Val Asn Glu Val Leu Ile 
                885                 890                 895     


His Ser Ser Gln Tyr Leu Met Glu Val Thr His Asp Leu Arg Leu Arg 
            900                 905                 910         


Leu Lys Asn Tyr Met Met Pro Ala Lys Gly Lys Lys Thr Asp Lys Gln 
        915                 920                 925             


Pro Leu Gln Lys Pro Ser His Cys Thr Ile Tyr Val Ala Lys Asn Tyr 
    930                 935                 940                 


Pro Pro Trp Gln His Thr Thr Leu Ser Val Leu Arg Lys His Phe Glu 
945                 950                 955                 960 


Ala Asn Asn Gly Lys Leu Pro Asp Asn Lys Val Ile Ala Ser Glu Leu 
                965                 970                 975     


Gly Ser Met Pro Glu Leu Lys Lys Tyr Met Lys Lys Val Met Pro Phe 
            980                 985                 990         


Val Ala Met Ile Lys Glu Asn Leu  Glu Lys Met Gly Pro  Arg Ile Leu 
        995                 1000                 1005             


Asp Leu  Gln Leu Glu Phe Asp  Glu Lys Ala Val Leu  Met Glu Asn 
    1010                 1015                 1020             


Ile Val  Tyr Leu Thr Asn Ser  Leu Glu Leu Glu His  Ile Glu Val 
    1025                 1030                 1035             


Lys Phe  Ala Ser Glu Ala Glu  Asp Lys Ile Arg Glu  Asp Cys Cys 
    1040                 1045                 1050             


Pro Gly  Lys Pro Leu Asn Val  Phe Arg Ile Glu Pro  Gly Val Ser 
    1055                 1060                 1065             


Val Ser  Leu Val Asn Pro Gln  Pro Ser Asn Gly His  Phe Ser Thr 
    1070                 1075                 1080             


Lys Ile  Glu Ile Arg Gln Gly  Asp Asn Cys Asp Ser  Ile Ile Arg 
    1085                 1090                 1095             


Arg Leu  Met Lys Met Asn Arg  Gly Ile Lys Asp Leu  Ser Lys Val 
    1100                 1105                 1110             


Lys Leu  Met Arg Phe Asp Asp  Pro Leu Leu Gly Pro  Arg Arg Val 
    1115                 1120                 1125             


Pro Val  Leu Gly Lys Glu Tyr  Thr Glu Lys Thr Pro  Ile Ser Glu 
    1130                 1135                 1140             


His Ala  Val Phe Asn Val Asp  Leu Met Ser Lys Lys  Ile His Leu 
    1145                 1150                 1155             


Thr Glu  Asn Gly Ile Arg Val  Asp Ile Gly Asp Thr  Ile Ile Tyr 
    1160                 1165                 1170             


Leu Val  His 
    1175     


<210>  1198
<211>  1017
<212>  DNA
<213>  Homosapiens

<400>  1198
atgatggcca tgaactccaa gcagcctttc ggcatgcacc cggtgctgca agaacccaaa     60

ttctccagtc tgcactctgg ctccgaggct atgcgccgag tctgtctccc agccccgcag    120

ctgcagggta atatatttgg aagctttgat gagagcctgc tggcacgcgc cgaagctctg    180

gcggcggtgg atatcgtctc ccacggcaag aaccatccgt tcaagcccga cgccacctac    240

cataccatga gcagcgtgcc ctgcacgtcc acttcgtcca ccgtgcccat ctcccaccca    300

gctgcgctca cctcacaccc tcaccacgcc gtgcaccagg gcctcgaagg cgacctgctg    360

gagcacatct cgcccacgct gagtgtgagc ggcctgggcg ctccggaaca ctcggtgatg    420

cccgcacaga tccatccaca ccacctgggc gccatgggcc acctgcacca ggccatgggc    480

atgagtcacc cgcacaccgt ggcccctcat agcgccatgc ctgcatgcct cagcgacgtg    540

gagtcagacc cgcgcgagct ggaagccttc gccgagcgct tcaagcagcg gcgcatcaag    600

ctgggggtga cccaggcgga cgtgggcgcg gctctggcta atctcaagat ccccggcgtg    660

ggctcgctga gccaaagcac catctgcagg ttcgagtctc tcactctctc gcacaacaac    720

atgatcgctc tcaagccggt gctccaggcc tggttggagg aggccgaggc cgcctaccga    780

gagaagaaca gcaagccaga gctcttcaac ggcagcgaac ggaagcgcaa acgcacgtcc    840

atcgcggcgc cggagaagcg ttcactcgag gcctatttcg ctatccagcc acgtccttca    900

tctgagaaga tcgcggccat cgctgagaaa ctggacctta aaaagaacgt ggtgagagtc    960

tggttctgca accagagaca gaaacagaaa cgaatgaagt attcggctgt ccactga      1017


<210>  1199
<211>  338
<212>  PRT
<213>  Homosapiens

<400>  1199

Met Met Ala Met Asn Ser Lys Gln Pro Phe Gly Met His Pro Val Leu 
1               5                   10                  15      


Gln Glu Pro Lys Phe Ser Ser Leu His Ser Gly Ser Glu Ala Met Arg 
            20                  25                  30          


Arg Val Cys Leu Pro Ala Pro Gln Leu Gln Gly Asn Ile Phe Gly Ser 
        35                  40                  45              


Phe Asp Glu Ser Leu Leu Ala Arg Ala Glu Ala Leu Ala Ala Val Asp 
    50                  55                  60                  


Ile Val Ser His Gly Lys Asn His Pro Phe Lys Pro Asp Ala Thr Tyr 
65                  70                  75                  80  


His Thr Met Ser Ser Val Pro Cys Thr Ser Thr Ser Ser Thr Val Pro 
                85                  90                  95      


Ile Ser His Pro Ala Ala Leu Thr Ser His Pro His His Ala Val His 
            100                 105                 110         


Gln Gly Leu Glu Gly Asp Leu Leu Glu His Ile Ser Pro Thr Leu Ser 
        115                 120                 125             


Val Ser Gly Leu Gly Ala Pro Glu His Ser Val Met Pro Ala Gln Ile 
    130                 135                 140                 


His Pro His His Leu Gly Ala Met Gly His Leu His Gln Ala Met Gly 
145                 150                 155                 160 


Met Ser His Pro His Thr Val Ala Pro His Ser Ala Met Pro Ala Cys 
                165                 170                 175     


Leu Ser Asp Val Glu Ser Asp Pro Arg Glu Leu Glu Ala Phe Ala Glu 
            180                 185                 190         


Arg Phe Lys Gln Arg Arg Ile Lys Leu Gly Val Thr Gln Ala Asp Val 
        195                 200                 205             


Gly Ala Ala Leu Ala Asn Leu Lys Ile Pro Gly Val Gly Ser Leu Ser 
    210                 215                 220                 


Gln Ser Thr Ile Cys Arg Phe Glu Ser Leu Thr Leu Ser His Asn Asn 
225                 230                 235                 240 


Met Ile Ala Leu Lys Pro Val Leu Gln Ala Trp Leu Glu Glu Ala Glu 
                245                 250                 255     


Ala Ala Tyr Arg Glu Lys Asn Ser Lys Pro Glu Leu Phe Asn Gly Ser 
            260                 265                 270         


Glu Arg Lys Arg Lys Arg Thr Ser Ile Ala Ala Pro Glu Lys Arg Ser 
        275                 280                 285             


Leu Glu Ala Tyr Phe Ala Ile Gln Pro Arg Pro Ser Ser Glu Lys Ile 
    290                 295                 300                 


Ala Ala Ile Ala Glu Lys Leu Asp Leu Lys Lys Asn Val Val Arg Val 
305                 310                 315                 320 


Trp Phe Cys Asn Gln Arg Gln Lys Gln Lys Arg Met Lys Tyr Ser Ala 
                325                 330                 335     


Val His 
        


<210>  1200
<211>  519
<212>  DNA
<213>  Homosapiens

<400>  1200
atggatgtaa aggaccggcg acaccgctct ttgaccagag gacgctgtgg caaagagtgt     60

cgctacacaa gctcctctct ggacagtgag gactgccgcg tgcccacaca gaaatcctac    120

agctccagtg agactctgaa ggcctatgac catgacagca ggatgcacta tggaaaccga    180

gtcacagacc tcatccaccg ggagtcagat gagtttccta gacaaggaac caacttcacc    240

cttgccgaac tgggcatctg tgagccctcc ccacaccgaa gcggctactg ctccgacatg    300

gggatccttc accagggcta ctcccttagc acagggtctg acgccgactc cgacaccgag    360

ggagggatgt ctccagaaca cgccatcaga ctgtggggca gagggataaa atccaggcgc    420

agttccggcc tgtccagtcg tgaaaactcg gcccttaccc tgactgactc tgacaacgaa    480

aacaaatcag atgatgagaa cggtaggcct gcttcttaa                           519


<210>  1201
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  1201

Met Asp Val Lys Asp Arg Arg His Arg Ser Leu Thr Arg Gly Arg Cys 
1               5                   10                  15      


Gly Lys Glu Cys Arg Tyr Thr Ser Ser Ser Leu Asp Ser Glu Asp Cys 
            20                  25                  30          


Arg Val Pro Thr Gln Lys Ser Tyr Ser Ser Ser Glu Thr Leu Lys Ala 
        35                  40                  45              


Tyr Asp His Asp Ser Arg Met His Tyr Gly Asn Arg Val Thr Asp Leu 
    50                  55                  60                  


Ile His Arg Glu Ser Asp Glu Phe Pro Arg Gln Gly Thr Asn Phe Thr 
65                  70                  75                  80  


Leu Ala Glu Leu Gly Ile Cys Glu Pro Ser Pro His Arg Ser Gly Tyr 
                85                  90                  95      


Cys Ser Asp Met Gly Ile Leu His Gln Gly Tyr Ser Leu Ser Thr Gly 
            100                 105                 110         


Ser Asp Ala Asp Ser Asp Thr Glu Gly Gly Met Ser Pro Glu His Ala 
        115                 120                 125             


Ile Arg Leu Trp Gly Arg Gly Ile Lys Ser Arg Arg Ser Ser Gly Leu 
    130                 135                 140                 


Ser Ser Arg Glu Asn Ser Ala Leu Thr Leu Thr Asp Ser Asp Asn Glu 
145                 150                 155                 160 


Asn Lys Ser Asp Asp Glu Asn Gly Arg Pro Ala Ser 
                165                 170         


<210>  1202
<211>  3636
<212>  DNA
<213>  Homosapiens

<400>  1202
atggatccgc cggcgggagc cgctcgccgc ctgctctgcc ccgcgctgct gctgctgctg     60

ctgctgctgc cgccgccgct cctgccgccg ccgccgccgc ccgcgaacgc caggctcgcc    120

gccgccgccg accccccagg cgggcccctg gggcacggag cggagcgcat cctggcggtg    180

cccgtgcgca ctgacgccca gggccgcttg gtgtcccacg tggtgtcggc agctacgtcc    240

agagcagggg tacgagcccg cagggccgcc ccggtccgga ccccgagctt ccccggaggc    300

aacgaggagg agcctggcag tcacctcttc tacaatgtca cggtctttgg ccgagacctg    360

cacctgcggc tgcggcccaa cgcccgcctc gtggcgcccg gggccactat ggagtggcag    420

ggcgagaagg gcaccacccg cgtggagccc ctgctcggga gctgtctcta cgtcggagac    480

gtggccggcc tagccgaagc ctcctctgtg gcgctcagca actgcgatgg gctggctggt    540

ctgatccgga tggaggagga ggagttcttc atcgaaccct tggagaaggg gctggcggcg    600

caggaggctg agcaaggccg tgtgcatgtg gtgtatcgcc ggccacccac gtcccctcct    660

ctcggggggc cacaggccct ggacacaggg gcctccctgg acagcctgga cagcctcagc    720

cgcgccctgg gcgtcctaga ggagcacgcc aacagctcga ggcggagggc acgcaggcat    780

gctgcagacg atgactacaa catcgaggtc ctgctgggcg tggatgactc tgtggtgcag    840

ttccacggga aggagcacgt acagaagtac ctgctgacac tcatgaacat tgtcaatgaa    900

atctaccatg acgagtcctt gggtgcccac atcaacgtgg tcctggtgcg gatcatcctc    960

ctgagctatg gaaagtccat gagcctcatc gagatcggga acccctctca gagcctggag   1020

aatgtctgcc gctgggccta cctccagcag aagccagaca cgggccacga tgaataccac   1080

gatcacgcca tcttcctcac acggcaggac tttgggcctt ccggcatgca aggctatgct   1140

cctgtcaccg gcatgtgcca tccggtccgc agctgcaccc tgaaccatga ggacggcttc   1200

tcctcagcgt ttgtggtggc ccatgagact ggccacgtgc tgggcatgga gcacgacggg   1260

cagggcaacc gctgtggcga cgaggtgcgg ctgggcagca tcatggcgcc cctggtgcag   1320

gccgccttcc accgcttcca ctggtcccgc tgcagccagc aggagctgag ccgctacctg   1380

cactcctatg actgcctgct ggatgacccc ttcgcccacg actggccggc gctgccccag   1440

ctcccgggac tgcactactc catgaacgag caatgccgct ttgacttcgg cctgggctac   1500

atgatgtgca cggcgttccg gacctttgac ccctgcaagc agctgtggtg cagccatcct   1560

gacaacccct acttttgcaa gaccaagaag gggcccccct tggacgggac tatgtgtgca   1620

cctggcaagc attgttttaa aggacactgc atctggctga cacctgacat cctcaaacgg   1680

gacggcagct ggggcgcttg gagtccgttt ggctcctgct cacgtacctg tggcacgggc   1740

gtgaagttca ggacccgcca gtgtgacaac ccacacccgg ccaacggggg ccgcacctgc   1800

tcgggccttg cctacgactt ccagctctgc agccgccagg actgccccga ctccctggct   1860

gacttccgcg aggagcagtg ccgccagtgg gacctgtact tcgagcacgg cgacgcccag   1920

caccactggc tgccccacga gcaccgggat gccaaggaga gatgccacct gtactgcgag   1980

tccagggaga ccggggaggt ggtgtccatg aagcgcatgg tgcatgatgg gacgcgctgc   2040

tcctacaagg acgccttcag cctctgtgtg cgcggggact gcaggaaggt gggctgtgac   2100

ggtgtgatcg gctccagcaa gcaggaagac aagtgtggcg tgtgcggagg ggacaacagc   2160

cactgcaaag tggtcaaggg cacgttcaca cggtcaccca agaagcatgg ttacatcaag   2220

atgtttgaga tccctgcagg agccagacac ctgctcattc aggaggtaga cgccaccagc   2280

caccatctgg ccgtcaagaa cctggagaca ggcaagttca tcttaaatga agagaatgac   2340

gtggatgcca gttccaaaac cttcattgcc atgggcgtgg agtgggagta cagagacgag   2400

gacggccggg agacgctgca gaccatgggc cccctccacg gcaccatcac cgttctggtc   2460

atcccggtgg gagacacccg ggtctcactg acgtacaaat acatgatcca tgaggactca   2520

ctgaatgtcg atgacaacaa cgtcctggaa gaggactctg tggtctacga gtgggccctg   2580

aagaagtggt ctccgtgctc caagccctgt ggcggagggt cccagttcac caagtatggc   2640

tgccgccgga ggctggacca caagatggta caccgtggct tctgtgccgc cctctcgaag   2700

cccaaagcca tccgcagagc gtgcaaccca caggaatgct cccagccagt gtgggtcaca   2760

ggcgaatggg agccatgtag ccagacctgt gggcggacag gcatgcaggt gcgctccgtg   2820

cgctgcattc agccgctaca cgacaacacc acccgctccg tgcacgccaa gcactgcaat   2880

gacgcccggc ccgagagccg ccgggcctgc agccgcgagc tctgccctgg tcgttggcga   2940

gccgggccct ggtcccagtg ctcagtaacc tgtggcaacg gcacccagga gcggccagtg   3000

ccctgccgca ccgcggacga cagcttcggc atctgccagg aggagcgtcc tgagacagcg   3060

aggacctgca ggcttggccc ctgtccccga aacatctcag atccctccaa gaagagctac   3120

gtagttcagt ggctgtcccg cccggacccc gactcgccca tccggaagat ctcgtcaaag   3180

ggccactgcc aaggcgacaa gtcaatattc tgtaggatgg aagtcttgtc ccgctattgc   3240

tccatcccag gctacaacaa gctgtcctgc aagtcctgta acctgtacaa caacctcacc   3300

aacgtggagg gcaggataga gccaccgcct gggaagcaca acgacattga cgtgttcatg   3360

cctaccctcc cagtgcccac tgtagccatg gaggtgcggc catcaccaag cacccccctg   3420

gaggtccctc tcaatgcctc cagcaccaat gccacagagg atcacccaga aaccaatgcc   3480

gtagatgaac cctacaaaat ccatggcctg gaagatgaag tccagccacc caacctaatc   3540

cctcgacgac cgagccccta tgaaaagacc agaaaccaaa gaatccaaga gctcattgat   3600

gagatgcgga agaaagagat gctcggaaag ttctaa                             3636


<210>  1203
<211>  1211
<212>  PRT
<213>  Homosapiens

<400>  1203

Met Asp Pro Pro Ala Gly Ala Ala Arg Arg Leu Leu Cys Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Leu Leu Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Ala Asn Ala Arg Leu Ala Ala Ala Ala Asp Pro Pro Gly Gly 
        35                  40                  45              


Pro Leu Gly His Gly Ala Glu Arg Ile Leu Ala Val Pro Val Arg Thr 
    50                  55                  60                  


Asp Ala Gln Gly Arg Leu Val Ser His Val Val Ser Ala Ala Thr Ser 
65                  70                  75                  80  


Arg Ala Gly Val Arg Ala Arg Arg Ala Ala Pro Val Arg Thr Pro Ser 
                85                  90                  95      


Phe Pro Gly Gly Asn Glu Glu Glu Pro Gly Ser His Leu Phe Tyr Asn 
            100                 105                 110         


Val Thr Val Phe Gly Arg Asp Leu His Leu Arg Leu Arg Pro Asn Ala 
        115                 120                 125             


Arg Leu Val Ala Pro Gly Ala Thr Met Glu Trp Gln Gly Glu Lys Gly 
    130                 135                 140                 


Thr Thr Arg Val Glu Pro Leu Leu Gly Ser Cys Leu Tyr Val Gly Asp 
145                 150                 155                 160 


Val Ala Gly Leu Ala Glu Ala Ser Ser Val Ala Leu Ser Asn Cys Asp 
                165                 170                 175     


Gly Leu Ala Gly Leu Ile Arg Met Glu Glu Glu Glu Phe Phe Ile Glu 
            180                 185                 190         


Pro Leu Glu Lys Gly Leu Ala Ala Gln Glu Ala Glu Gln Gly Arg Val 
        195                 200                 205             


His Val Val Tyr Arg Arg Pro Pro Thr Ser Pro Pro Leu Gly Gly Pro 
    210                 215                 220                 


Gln Ala Leu Asp Thr Gly Ala Ser Leu Asp Ser Leu Asp Ser Leu Ser 
225                 230                 235                 240 


Arg Ala Leu Gly Val Leu Glu Glu His Ala Asn Ser Ser Arg Arg Arg 
                245                 250                 255     


Ala Arg Arg His Ala Ala Asp Asp Asp Tyr Asn Ile Glu Val Leu Leu 
            260                 265                 270         


Gly Val Asp Asp Ser Val Val Gln Phe His Gly Lys Glu His Val Gln 
        275                 280                 285             


Lys Tyr Leu Leu Thr Leu Met Asn Ile Val Asn Glu Ile Tyr His Asp 
    290                 295                 300                 


Glu Ser Leu Gly Ala His Ile Asn Val Val Leu Val Arg Ile Ile Leu 
305                 310                 315                 320 


Leu Ser Tyr Gly Lys Ser Met Ser Leu Ile Glu Ile Gly Asn Pro Ser 
                325                 330                 335     


Gln Ser Leu Glu Asn Val Cys Arg Trp Ala Tyr Leu Gln Gln Lys Pro 
            340                 345                 350         


Asp Thr Gly His Asp Glu Tyr His Asp His Ala Ile Phe Leu Thr Arg 
        355                 360                 365             


Gln Asp Phe Gly Pro Ser Gly Met Gln Gly Tyr Ala Pro Val Thr Gly 
    370                 375                 380                 


Met Cys His Pro Val Arg Ser Cys Thr Leu Asn His Glu Asp Gly Phe 
385                 390                 395                 400 


Ser Ser Ala Phe Val Val Ala His Glu Thr Gly His Val Leu Gly Met 
                405                 410                 415     


Glu His Asp Gly Gln Gly Asn Arg Cys Gly Asp Glu Val Arg Leu Gly 
            420                 425                 430         


Ser Ile Met Ala Pro Leu Val Gln Ala Ala Phe His Arg Phe His Trp 
        435                 440                 445             


Ser Arg Cys Ser Gln Gln Glu Leu Ser Arg Tyr Leu His Ser Tyr Asp 
    450                 455                 460                 


Cys Leu Leu Asp Asp Pro Phe Ala His Asp Trp Pro Ala Leu Pro Gln 
465                 470                 475                 480 


Leu Pro Gly Leu His Tyr Ser Met Asn Glu Gln Cys Arg Phe Asp Phe 
                485                 490                 495     


Gly Leu Gly Tyr Met Met Cys Thr Ala Phe Arg Thr Phe Asp Pro Cys 
            500                 505                 510         


Lys Gln Leu Trp Cys Ser His Pro Asp Asn Pro Tyr Phe Cys Lys Thr 
        515                 520                 525             


Lys Lys Gly Pro Pro Leu Asp Gly Thr Met Cys Ala Pro Gly Lys His 
    530                 535                 540                 


Cys Phe Lys Gly His Cys Ile Trp Leu Thr Pro Asp Ile Leu Lys Arg 
545                 550                 555                 560 


Asp Gly Ser Trp Gly Ala Trp Ser Pro Phe Gly Ser Cys Ser Arg Thr 
                565                 570                 575     


Cys Gly Thr Gly Val Lys Phe Arg Thr Arg Gln Cys Asp Asn Pro His 
            580                 585                 590         


Pro Ala Asn Gly Gly Arg Thr Cys Ser Gly Leu Ala Tyr Asp Phe Gln 
        595                 600                 605             


Leu Cys Ser Arg Gln Asp Cys Pro Asp Ser Leu Ala Asp Phe Arg Glu 
    610                 615                 620                 


Glu Gln Cys Arg Gln Trp Asp Leu Tyr Phe Glu His Gly Asp Ala Gln 
625                 630                 635                 640 


His His Trp Leu Pro His Glu His Arg Asp Ala Lys Glu Arg Cys His 
                645                 650                 655     


Leu Tyr Cys Glu Ser Arg Glu Thr Gly Glu Val Val Ser Met Lys Arg 
            660                 665                 670         


Met Val His Asp Gly Thr Arg Cys Ser Tyr Lys Asp Ala Phe Ser Leu 
        675                 680                 685             


Cys Val Arg Gly Asp Cys Arg Lys Val Gly Cys Asp Gly Val Ile Gly 
    690                 695                 700                 


Ser Ser Lys Gln Glu Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser 
705                 710                 715                 720 


His Cys Lys Val Val Lys Gly Thr Phe Thr Arg Ser Pro Lys Lys His 
                725                 730                 735     


Gly Tyr Ile Lys Met Phe Glu Ile Pro Ala Gly Ala Arg His Leu Leu 
            740                 745                 750         


Ile Gln Glu Val Asp Ala Thr Ser His His Leu Ala Val Lys Asn Leu 
        755                 760                 765             


Glu Thr Gly Lys Phe Ile Leu Asn Glu Glu Asn Asp Val Asp Ala Ser 
    770                 775                 780                 


Ser Lys Thr Phe Ile Ala Met Gly Val Glu Trp Glu Tyr Arg Asp Glu 
785                 790                 795                 800 


Asp Gly Arg Glu Thr Leu Gln Thr Met Gly Pro Leu His Gly Thr Ile 
                805                 810                 815     


Thr Val Leu Val Ile Pro Val Gly Asp Thr Arg Val Ser Leu Thr Tyr 
            820                 825                 830         


Lys Tyr Met Ile His Glu Asp Ser Leu Asn Val Asp Asp Asn Asn Val 
        835                 840                 845             


Leu Glu Glu Asp Ser Val Val Tyr Glu Trp Ala Leu Lys Lys Trp Ser 
    850                 855                 860                 


Pro Cys Ser Lys Pro Cys Gly Gly Gly Ser Gln Phe Thr Lys Tyr Gly 
865                 870                 875                 880 


Cys Arg Arg Arg Leu Asp His Lys Met Val His Arg Gly Phe Cys Ala 
                885                 890                 895     


Ala Leu Ser Lys Pro Lys Ala Ile Arg Arg Ala Cys Asn Pro Gln Glu 
            900                 905                 910         


Cys Ser Gln Pro Val Trp Val Thr Gly Glu Trp Glu Pro Cys Ser Gln 
        915                 920                 925             


Thr Cys Gly Arg Thr Gly Met Gln Val Arg Ser Val Arg Cys Ile Gln 
    930                 935                 940                 


Pro Leu His Asp Asn Thr Thr Arg Ser Val His Ala Lys His Cys Asn 
945                 950                 955                 960 


Asp Ala Arg Pro Glu Ser Arg Arg Ala Cys Ser Arg Glu Leu Cys Pro 
                965                 970                 975     


Gly Arg Trp Arg Ala Gly Pro Trp Ser Gln Cys Ser Val Thr Cys Gly 
            980                 985                 990         


Asn Gly Thr Gln Glu Arg Pro Val  Pro Cys Arg Thr Ala  Asp Asp Ser 
        995                 1000                 1005             


Phe Gly  Ile Cys Gln Glu Glu  Arg Pro Glu Thr Ala  Arg Thr Cys 
    1010                 1015                 1020             


Arg Leu  Gly Pro Cys Pro Arg  Asn Ile Ser Asp Pro  Ser Lys Lys 
    1025                 1030                 1035             


Ser Tyr  Val Val Gln Trp Leu  Ser Arg Pro Asp Pro  Asp Ser Pro 
    1040                 1045                 1050             


Ile Arg  Lys Ile Ser Ser Lys  Gly His Cys Gln Gly  Asp Lys Ser 
    1055                 1060                 1065             


Ile Phe  Cys Arg Met Glu Val  Leu Ser Arg Tyr Cys  Ser Ile Pro 
    1070                 1075                 1080             


Gly Tyr  Asn Lys Leu Ser Cys  Lys Ser Cys Asn Leu  Tyr Asn Asn 
    1085                 1090                 1095             


Leu Thr  Asn Val Glu Gly Arg  Ile Glu Pro Pro Pro  Gly Lys His 
    1100                 1105                 1110             


Asn Asp  Ile Asp Val Phe Met  Pro Thr Leu Pro Val  Pro Thr Val 
    1115                 1120                 1125             


Ala Met  Glu Val Arg Pro Ser  Pro Ser Thr Pro Leu  Glu Val Pro 
    1130                 1135                 1140             


Leu Asn  Ala Ser Ser Thr Asn  Ala Thr Glu Asp His  Pro Glu Thr 
    1145                 1150                 1155             


Asn Ala  Val Asp Glu Pro Tyr  Lys Ile His Gly Leu  Glu Asp Glu 
    1160                 1165                 1170             


Val Gln  Pro Pro Asn Leu Ile  Pro Arg Arg Pro Ser  Pro Tyr Glu 
    1175                 1180                 1185             


Lys Thr  Arg Asn Gln Arg Ile  Gln Glu Leu Ile Asp  Glu Met Arg 
    1190                 1195                 1200             


Lys Lys  Glu Met Leu Gly Lys  Phe 
    1205                 1210     


<210>  1204
<211>  1701
<212>  DNA
<213>  Homosapiens

<400>  1204
atggatccgc cggcgggagc cgctcgccgc ctgctctgcc ccgcgctgct gctgctgctg     60

ctgctgctgc cgccgccgct cctgccgccg ccgccgccgc ccgcgaacgc caggctcgcc    120

gccgccgccg accccccagg cgggcccctg gggcacggag cggagcgcat cctggcggtg    180

cccgtgcgca ctgacgccca gggccgcttg gtgtcccacg tggtgtcggc agctacgtcc    240

agagcagggg tacgagcccg cagggccgcc ccggtccgga ccccgagctt ccccggaggc    300

aacgaggagg agcctggcag tcacctcttc tacaatgtca cggtctttgg ccgagacctg    360

cacctgcggc tgcggcccaa cgcccgcctc gtggcgcccg gggccactat ggagtggcag    420

ggcgagaagg gcaccacccg cgtggagccc ctgctcggga gctgtctcta cgtcggagac    480

gtggccggcc tagccgaagc ctcctctgtg gcgctcagca actgcgatgg gctggctggt    540

ctgatccgga tggaggagga ggagttcttc atcgaaccct tggagaaggg gctggcggcg    600

caggaggctg agcaaggccg tgtgcatgtg gtgtatcgcc ggccacccac gtcccctcct    660

ctcggggggc cacaggccct ggacacaggg gcctccctgg acagcctgga cagcctcagc    720

cgcgccctgg gcgtcctaga ggagcacgcc aacagctcga ggcggagggc acgcaggcat    780

gctgcagacg atgactacaa catcgaggtc ctgctgggcg tggatgactc tgtggtgcag    840

ttccacggga aggagcacgt acagaagtac ctgctgacac tcatgaacat tgtcaatgaa    900

atctaccatg acgagtcctt gggtgcccac atcaacgtgg tcctggtgcg gatcatcctc    960

ctgagctatg gaaagtccat gagcctcatc gagatcggga acccctctca gagcctggag   1020

aatgtctgcc gctgggccta cctccagcag aagccagaca cgggccacga tgaataccac   1080

gatcacgcca tcttcctcac acggcaggac tttgggcctt ccggcatgca aggctatgct   1140

cctgtcaccg gcatgtgcca tccggtccgc agctgcaccc tgaaccatga ggacggcttc   1200

tcctcagcgt ttgtggtggc ccatgagact ggccacgtgc tgggcatgga gcacgacggg   1260

cagggcaacc gctgtggcga cgaggtgcgg ctgggcagca tcatggcgcc cctggtgcag   1320

gccgccttcc accgcttcca ctggtcccgc tgcagccagc aggagctgag ccgctacctg   1380

cactcctatg actgcctgct ggatgacccc ttcgcccacg actggccggc gctgccccag   1440

ctcccgggac tgcactactc catgaacgag caatgccgct ttgacttcgg cctgggctac   1500

atgatgtgca cggcgttccg gacctttgac ccctgcaagc agctgtggtg cagccatcct   1560

gacaacccct acttttgcaa gaccaagaag gggcccccct tggacgggac tatgtgtgca   1620

cctggcaagt tcaggccggg cgcggtggct catgcctgtt atcccagcac tttgggaggc   1680

caaggtaggt ggatcgcctg a                                             1701


<210>  1205
<211>  566
<212>  PRT
<213>  Homosapiens

<400>  1205

Met Asp Pro Pro Ala Gly Ala Ala Arg Arg Leu Leu Cys Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Leu Leu Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Ala Asn Ala Arg Leu Ala Ala Ala Ala Asp Pro Pro Gly Gly 
        35                  40                  45              


Pro Leu Gly His Gly Ala Glu Arg Ile Leu Ala Val Pro Val Arg Thr 
    50                  55                  60                  


Asp Ala Gln Gly Arg Leu Val Ser His Val Val Ser Ala Ala Thr Ser 
65                  70                  75                  80  


Arg Ala Gly Val Arg Ala Arg Arg Ala Ala Pro Val Arg Thr Pro Ser 
                85                  90                  95      


Phe Pro Gly Gly Asn Glu Glu Glu Pro Gly Ser His Leu Phe Tyr Asn 
            100                 105                 110         


Val Thr Val Phe Gly Arg Asp Leu His Leu Arg Leu Arg Pro Asn Ala 
        115                 120                 125             


Arg Leu Val Ala Pro Gly Ala Thr Met Glu Trp Gln Gly Glu Lys Gly 
    130                 135                 140                 


Thr Thr Arg Val Glu Pro Leu Leu Gly Ser Cys Leu Tyr Val Gly Asp 
145                 150                 155                 160 


Val Ala Gly Leu Ala Glu Ala Ser Ser Val Ala Leu Ser Asn Cys Asp 
                165                 170                 175     


Gly Leu Ala Gly Leu Ile Arg Met Glu Glu Glu Glu Phe Phe Ile Glu 
            180                 185                 190         


Pro Leu Glu Lys Gly Leu Ala Ala Gln Glu Ala Glu Gln Gly Arg Val 
        195                 200                 205             


His Val Val Tyr Arg Arg Pro Pro Thr Ser Pro Pro Leu Gly Gly Pro 
    210                 215                 220                 


Gln Ala Leu Asp Thr Gly Ala Ser Leu Asp Ser Leu Asp Ser Leu Ser 
225                 230                 235                 240 


Arg Ala Leu Gly Val Leu Glu Glu His Ala Asn Ser Ser Arg Arg Arg 
                245                 250                 255     


Ala Arg Arg His Ala Ala Asp Asp Asp Tyr Asn Ile Glu Val Leu Leu 
            260                 265                 270         


Gly Val Asp Asp Ser Val Val Gln Phe His Gly Lys Glu His Val Gln 
        275                 280                 285             


Lys Tyr Leu Leu Thr Leu Met Asn Ile Val Asn Glu Ile Tyr His Asp 
    290                 295                 300                 


Glu Ser Leu Gly Ala His Ile Asn Val Val Leu Val Arg Ile Ile Leu 
305                 310                 315                 320 


Leu Ser Tyr Gly Lys Ser Met Ser Leu Ile Glu Ile Gly Asn Pro Ser 
                325                 330                 335     


Gln Ser Leu Glu Asn Val Cys Arg Trp Ala Tyr Leu Gln Gln Lys Pro 
            340                 345                 350         


Asp Thr Gly His Asp Glu Tyr His Asp His Ala Ile Phe Leu Thr Arg 
        355                 360                 365             


Gln Asp Phe Gly Pro Ser Gly Met Gln Gly Tyr Ala Pro Val Thr Gly 
    370                 375                 380                 


Met Cys His Pro Val Arg Ser Cys Thr Leu Asn His Glu Asp Gly Phe 
385                 390                 395                 400 


Ser Ser Ala Phe Val Val Ala His Glu Thr Gly His Val Leu Gly Met 
                405                 410                 415     


Glu His Asp Gly Gln Gly Asn Arg Cys Gly Asp Glu Val Arg Leu Gly 
            420                 425                 430         


Ser Ile Met Ala Pro Leu Val Gln Ala Ala Phe His Arg Phe His Trp 
        435                 440                 445             


Ser Arg Cys Ser Gln Gln Glu Leu Ser Arg Tyr Leu His Ser Tyr Asp 
    450                 455                 460                 


Cys Leu Leu Asp Asp Pro Phe Ala His Asp Trp Pro Ala Leu Pro Gln 
465                 470                 475                 480 


Leu Pro Gly Leu His Tyr Ser Met Asn Glu Gln Cys Arg Phe Asp Phe 
                485                 490                 495     


Gly Leu Gly Tyr Met Met Cys Thr Ala Phe Arg Thr Phe Asp Pro Cys 
            500                 505                 510         


Lys Gln Leu Trp Cys Ser His Pro Asp Asn Pro Tyr Phe Cys Lys Thr 
        515                 520                 525             


Lys Lys Gly Pro Pro Leu Asp Gly Thr Met Cys Ala Pro Gly Lys Phe 
    530                 535                 540                 


Arg Pro Gly Ala Val Ala His Ala Cys Tyr Pro Ser Thr Leu Gly Gly 
545                 550                 555                 560 


Gln Gly Arg Trp Ile Ala 
                565     


<210>  1206
<211>  591
<212>  DNA
<213>  Homosapiens

<400>  1206
atggtccagt caggcggccc cgacttcagg tcagagggca cggaggacgt ccgggcagag     60

gacttggagg acgtcagggc agaggacttg gaggacgtca gggcagagag cacagagtac    120

gtcagggcag agagcaagga ggacgtcagg gcagaggact cagagggcgt tggggcagag    180

ggcacagagg acgtcggtgc agaggactca gaggacgtca gggcagaggg cacggaggac    240

gttggggcag aggacttgga ggacgtcagg gcagaaggca cagaggacgt cgggacagag    300

ggcacggagg acgtcggggc agaggactca gaggacatca gggcagagag ctcagaggac    360

atcggggcag agagcacaga ggacgtcggg gcagagggca cggaggacgt cggggcagag    420

gactcagagg acattggggc agagagcacg caggacgtca gggcagagga ctcagaggac    480

gtcggggcag agggcacgga ggacgttggg gcagagggca cagaggacgt cggggcagag    540

gactcaggat gccatgcagt tcccacccag atgggaacgc agaagtgctg a             591


<210>  1207
<211>  196
<212>  PRT
<213>  Homosapiens

<400>  1207

Met Val Gln Ser Gly Gly Pro Asp Phe Arg Ser Glu Gly Thr Glu Asp 
1               5                   10                  15      


Val Arg Ala Glu Asp Leu Glu Asp Val Arg Ala Glu Asp Leu Glu Asp 
            20                  25                  30          


Val Arg Ala Glu Ser Thr Glu Tyr Val Arg Ala Glu Ser Lys Glu Asp 
        35                  40                  45              


Val Arg Ala Glu Asp Ser Glu Gly Val Gly Ala Glu Gly Thr Glu Asp 
    50                  55                  60                  


Val Gly Ala Glu Asp Ser Glu Asp Val Arg Ala Glu Gly Thr Glu Asp 
65                  70                  75                  80  


Val Gly Ala Glu Asp Leu Glu Asp Val Arg Ala Glu Gly Thr Glu Asp 
                85                  90                  95      


Val Gly Thr Glu Gly Thr Glu Asp Val Gly Ala Glu Asp Ser Glu Asp 
            100                 105                 110         


Ile Arg Ala Glu Ser Ser Glu Asp Ile Gly Ala Glu Ser Thr Glu Asp 
        115                 120                 125             


Val Gly Ala Glu Gly Thr Glu Asp Val Gly Ala Glu Asp Ser Glu Asp 
    130                 135                 140                 


Ile Gly Ala Glu Ser Thr Gln Asp Val Arg Ala Glu Asp Ser Glu Asp 
145                 150                 155                 160 


Val Gly Ala Glu Gly Thr Glu Asp Val Gly Ala Glu Gly Thr Glu Asp 
                165                 170                 175     


Val Gly Ala Glu Asp Ser Gly Cys His Ala Val Pro Thr Gln Met Gly 
            180                 185                 190         


Thr Gln Lys Cys 
        195     


<210>  1208
<211>  2052
<212>  DNA
<213>  Homosapiens

<400>  1208
gacagctgtg tctcgatgga gtagactctc agaacagcgc agtttgccct ccgctcacgc     60

agagcctctc cgtggcttcc gcaccttgag cattaggcca gttctcctct tctctctaat    120

ccatccgtca cctctcctgt catccgtttc catgccgtga ggtccattca cagaacacat    180

ccatggctct catgctcagt ttggttctga gtctcctcaa gctgggatca gggcagtggc    240

aggtgtttgg gccagacaag cctgtccagg ccttggtggg ggaggacgca gcattctcct    300

gtttcctgtc tcctaagacc aatgcagagg ccatggaagt gcggttcttc aggggccagt    360

tctctagcgt ggtccacctc tacagggacg ggaaggacca gccatttatg cagatgccac    420

agtatcaagg caggacaaaa ctggtgaagg attctattgc ggaggggcgc atctctctga    480

ggctggaaaa cattactgtg ttggatgctg gcctctatgg gtgcaggatt agttcccagt    540

cttactacca gaaggccatc tgggagctac aggtgtcagc actgggctca gttcctctca    600

tttccatcac gggatatgtt gatagagaca tccagctact ctgtcagtcc tcgggctggt    660

tcccccggcc cacagcgaag tggaaaggtc cacaaggaca ggatttgtcc acagactcca    720

ggacaaacag agacatgcat ggcctgtttg atgtggagat ctctctgacc gtccaagaga    780

acgccgggag catatcctgt tccatgcggc atgctcatct gagccgagag gtggaatcca    840

gggtacagat aggagatacc tttttcgagc ctatatcgtg gcacctggct accaaagtac    900

tgggaatact ctgctgtggc ctattttttg gcattgttgg actgaagatt ttcttctcca    960

aattccagtg gaaaatccag gcggaactgg actggagaag aaagcacgga caggcagaat   1020

tgagagacgc ccggaaacac gcagtggagg tgactctgga tccagagacg gctcacccga   1080

agctctgcgt ttctgatctg aaaactgtaa cccatagaaa agctccccag gaggtgcctc   1140

actctgagaa gagatttaca aggaagagtg tggtggcttc tcagagtttc caagcaggga   1200

aacattactg ggaggtggac ggaggacaca ataaaaggtg gcgcgtggga gtgtgccggg   1260

atgatgtgga caggaggaag gagtacgtga ctttgtctcc cgatcatggg tactgggtcc   1320

tcagactgaa tggagaacat ttgtatttca cattaaatcc ccgttttatc agcgtcttcc   1380

ccaggacccc acctacaaaa ataggggtct tcctggacta tgagtgtggg accatctcct   1440

tcttcaacat aaatgaccag tcccttattt ataccctgac atgtcggttt gaaggcttat   1500

tgaggcccta cattgagtat ccgtcctata atgagcaaaa tggaactccc atagtcatct   1560

gcccagtcac ccaggaatca gagaaagagg cctcttggca aagggcctct gcaatcccag   1620

agacaagcaa cagtgagtcc tcctcacagg caaccacgcc cttcctcccc aggggtgaaa   1680

tgtaggatga atcacatccc acattcttct ttagggatat taaggtctct ctcccagatc   1740

caaagtcccg cagcagccgg ccaaggtggc ttccagatga agggggactg gcctgtccac   1800

atgggagtca ggtgtcatgg ctgccctgag ctgggaggga agaaggctga cattacattt   1860

agtttgctct cactccatct ggctaagtga tcttgaaata ccacctctca ggtgaagaac   1920

cgtcaggaat tcccatctca caggctgtgg tgtagattaa gtagacaagg aatgtgaata   1980

atgcttagat cttattgatg acagagtgta tcctaatggt ttgttcatta tattacactt   2040

tcagtaaaaa aa                                                       2052


<210>  1209
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  1209

Met Ala Leu Met Leu Ser Leu Val Leu Ser Leu Leu Lys Leu Gly Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Phe Gly Pro Asp Lys Pro Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Ala Phe Ser Cys Phe Leu Ser Pro Lys Thr Asn Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Gly Gln Phe Ser Ser Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Lys Asp Gln Pro Phe Met Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Gln Gly Arg Thr Lys Leu Val Lys Asp Ser Ile Ala Glu Gly Arg 
                85                  90                  95      


Ile Ser Leu Arg Leu Glu Asn Ile Thr Val Leu Asp Ala Gly Leu Tyr 
            100                 105                 110         


Gly Cys Arg Ile Ser Ser Gln Ser Tyr Tyr Gln Lys Ala Ile Trp Glu 
        115                 120                 125             


Leu Gln Val Ser Ala Leu Gly Ser Val Pro Leu Ile Ser Ile Thr Gly 
    130                 135                 140                 


Tyr Val Asp Arg Asp Ile Gln Leu Leu Cys Gln Ser Ser Gly Trp Phe 
145                 150                 155                 160 


Pro Arg Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser 
                165                 170                 175     


Thr Asp Ser Arg Thr Asn Arg Asp Met His Gly Leu Phe Asp Val Glu 
            180                 185                 190         


Ile Ser Leu Thr Val Gln Glu Asn Ala Gly Ser Ile Ser Cys Ser Met 
        195                 200                 205             


Arg His Ala His Leu Ser Arg Glu Val Glu Ser Arg Val Gln Ile Gly 
    210                 215                 220                 


Asp Thr Phe Phe Glu Pro Ile Ser Trp His Leu Ala Thr Lys Val Leu 
225                 230                 235                 240 


Gly Ile Leu Cys Cys Gly Leu Phe Phe Gly Ile Val Gly Leu Lys Ile 
                245                 250                 255     


Phe Phe Ser Lys Phe Gln Trp Lys Ile Gln Ala Glu Leu Asp Trp Arg 
            260                 265                 270         


Arg Lys His Gly Gln Ala Glu Leu Arg Asp Ala Arg Lys His Ala Val 
        275                 280                 285             


Glu Val Thr Leu Asp Pro Glu Thr Ala His Pro Lys Leu Cys Val Ser 
    290                 295                 300                 


Asp Leu Lys Thr Val Thr His Arg Lys Ala Pro Gln Glu Val Pro His 
305                 310                 315                 320 


Ser Glu Lys Arg Phe Thr Arg Lys Ser Val Val Ala Ser Gln Ser Phe 
                325                 330                 335     


Gln Ala Gly Lys His Tyr Trp Glu Val Asp Gly Gly His Asn Lys Arg 
            340                 345                 350         


Trp Arg Val Gly Val Cys Arg Asp Asp Val Asp Arg Arg Lys Glu Tyr 
        355                 360                 365             


Val Thr Leu Ser Pro Asp His Gly Tyr Trp Val Leu Arg Leu Asn Gly 
    370                 375                 380                 


Glu His Leu Tyr Phe Thr Leu Asn Pro Arg Phe Ile Ser Val Phe Pro 
385                 390                 395                 400 


Arg Thr Pro Pro Thr Lys Ile Gly Val Phe Leu Asp Tyr Glu Cys Gly 
                405                 410                 415     


Thr Ile Ser Phe Phe Asn Ile Asn Asp Gln Ser Leu Ile Tyr Thr Leu 
            420                 425                 430         


Thr Cys Arg Phe Glu Gly Leu Leu Arg Pro Tyr Ile Glu Tyr Pro Ser 
        435                 440                 445             


Tyr Asn Glu Gln Asn Gly Thr Pro Ile Val Ile Cys Pro Val Thr Gln 
    450                 455                 460                 


Glu Ser Glu Lys Glu Ala Ser Trp Gln Arg Ala Ser Ala Ile Pro Glu 
465                 470                 475                 480 


Thr Ser Asn Ser Glu Ser Ser Ser Gln Ala Thr Thr Pro Phe Leu Pro 
                485                 490                 495     


Arg Gly Glu Met 
            500 


<210>  1210
<211>  2165
<212>  DNA
<213>  Homosapiens

<400>  1210
agaacagcgc agtttgccct ccgctcacgc agagcctctc cgtggcctcc gcaccttgag     60

cattaggcca gttctcctct tctctctaat ccatccgtca cctctcctgt catccgtttc    120

catgccgtga ggtccattca cagaacacat ccatggctct catgctcagt ttggttctga    180

gtctcctcaa gctgggatca gggcagtggc aggtgtttgg gccagacaag cctgtccagg    240

ccttggtggg ggaggacgca gcattctcct gtttcctgtc tcctaagacc aatgcagagg    300

ccatggaagt gcggttcttc aggggccagt tctctagcgt ggtccacctc tacagggacg    360

ggaaggacca gccatttatg cagatgccac agtatcaagg caggacaaaa ctggtgaagg    420

attctattgc ggaggggcgc atctctctga ggctggaaaa cattactgtg ttggatgctg    480

gcctctatgg gtgcaggatt agttcccagt cttactacca gaaggccatc tgggagctac    540

aggtgtcagc actgggctca gttcctctca tttccatcac gggatatgtt gatagagaca    600

tccagctact ctgtcagtcc tcgggctggt tcccccggcc cacagcgaag tggaaaggtc    660

cacaaggaca ggatttgtcc acagactcca ggacaaacag agacatgcat ggcctgtttg    720

atgtggagat ctctctgacc gtccaagaga acgccgggag catatcctgt tccatgcggc    780

atgctcatct gagccgagag gtggaatcca gggtacagat aggagatacc tttttcgagc    840

ctatatcgtg gcacctggct accaaagtac tgggaatact ctgctgtggc ctattttttg    900

gcattgttgg actgaagatt ttcttctcca aattccagtg taagcgagag agagaagcat    960

gggccggtgc cttattcatg gttccagcag ggacaggatc agagatgctc ccacatccag   1020

ctgcttctct tcttctagtc ctagcctcca ggggcccagg cccaaaaaag gaaaatccag   1080

gcggaactgg actggagaag aaagcacgga caggcagaat tgagagacgc ccggaaacac   1140

gcagtggagg tgactctgga tccagagacg gctcacccga agctctgcgt ttctgatctg   1200

aaaactgtaa cccatagaaa agctccccag gaggtgcctc actctgagaa gagatttaca   1260

aggaagagtg tggtggcttc tcagagtttc caagcaggga aacattactg ggaggtggac   1320

ggaggacaca ataaaaggtg gcgcgtggga gtgtgccggg atgatgtgga caggaggaag   1380

gagtacgtga ctttgtctcc cgatcatggg tactgggtcc tcagactgaa tggagaacat   1440

ttgtatttca cattaaatcc ccgttttatc agcgtcttcc ccaggacccc acctacaaaa   1500

ataggggtct tcctggacta tgagtgtggg accatctcct tcttcaacat aaatgaccag   1560

tcccttattt ataccctgac atgtcggttt gaaggcttat tgaggcccta cattgagtat   1620

ccgtcctata atgagcaaaa tggaactccc atagtcatct gcccagtcac ccaggaatca   1680

gagaaagagg cctcttggca aagggcctct gcaatcccag agacaagcaa cagtgagtcc   1740

tcctcacagg caaccacgcc cttcctcccc aggggtgaaa tgtaggatga atcacatccc   1800

acattcttct ttagggatat taaggtctct ctcccagatc caaagtcccg cagcagccgg   1860

ccaaggtggc ttccagatga agggggactg gcctgtccac atgggagtca ggtgtcatgg   1920

ctgccctgag ctgggaggga agaaggctga cattacattt agtttgctct cactccatct   1980

ggctaagtga tcttgaaata ccacctctca ggtgaagaac cgtcaggaat tcccatctca   2040

caggctgtgg tgtagattaa gtagacaagg aatgtgaata atgcttagat cttattgatg   2100

acagagtgta tcctaatggt ttgttcatta tattacactt tcagtaaaaa aaaaaaaaaa   2160

aaaaa                                                               2165


<210>  1211
<211>  347
<212>  PRT
<213>  Homosapiens

<400>  1211

Met Ala Leu Met Leu Ser Leu Val Leu Ser Leu Leu Lys Leu Gly Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Phe Gly Pro Asp Lys Pro Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Ala Phe Ser Cys Phe Leu Ser Pro Lys Thr Asn Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Gly Gln Phe Ser Ser Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Lys Asp Gln Pro Phe Met Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Gln Gly Arg Thr Lys Leu Val Lys Asp Ser Ile Ala Glu Gly Arg 
                85                  90                  95      


Ile Ser Leu Arg Leu Glu Asn Ile Thr Val Leu Asp Ala Gly Leu Tyr 
            100                 105                 110         


Gly Cys Arg Ile Ser Ser Gln Ser Tyr Tyr Gln Lys Ala Ile Trp Glu 
        115                 120                 125             


Leu Gln Val Ser Ala Leu Gly Ser Val Pro Leu Ile Ser Ile Thr Gly 
    130                 135                 140                 


Tyr Val Asp Arg Asp Ile Gln Leu Leu Cys Gln Ser Ser Gly Trp Phe 
145                 150                 155                 160 


Pro Arg Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser 
                165                 170                 175     


Thr Asp Ser Arg Thr Asn Arg Asp Met His Gly Leu Phe Asp Val Glu 
            180                 185                 190         


Ile Ser Leu Thr Val Gln Glu Asn Ala Gly Ser Ile Ser Cys Ser Met 
        195                 200                 205             


Arg His Ala His Leu Ser Arg Glu Val Glu Ser Arg Val Gln Ile Gly 
    210                 215                 220                 


Asp Thr Phe Phe Glu Pro Ile Ser Trp His Leu Ala Thr Lys Val Leu 
225                 230                 235                 240 


Gly Ile Leu Cys Cys Gly Leu Phe Phe Gly Ile Val Gly Leu Lys Ile 
                245                 250                 255     


Phe Phe Ser Lys Phe Gln Cys Lys Arg Glu Arg Glu Ala Trp Ala Gly 
            260                 265                 270         


Ala Leu Phe Met Val Pro Ala Gly Thr Gly Ser Glu Met Leu Pro His 
        275                 280                 285             


Pro Ala Ala Ser Leu Leu Leu Val Leu Ala Ser Arg Gly Pro Gly Pro 
    290                 295                 300                 


Lys Lys Glu Asn Pro Gly Gly Thr Gly Leu Glu Lys Lys Ala Arg Thr 
305                 310                 315                 320 


Gly Arg Ile Glu Arg Arg Pro Glu Thr Arg Ser Gly Gly Asp Ser Gly 
                325                 330                 335     


Ser Arg Asp Gly Ser Pro Glu Ala Leu Arg Phe 
            340                 345         


<210>  1212
<211>  2296
<212>  DNA
<213>  Homosapiens

<400>  1212
ttgacatcgt tcatgaagag cctctccacg gctcctgcgc ctgagacagc tggcctgacc     60

tccaaatcat ccatccaccc ctgctgtcat ctgttttcat agtgtgagat caacccacag    120

gaatatccat ggcttttgtg ctcattttgg ttctcagttt ctacgagctg gtgtcaggac    180

agtggcaagt cactggaccg ggcaagtttg tccaggcctt ggtgggggag gacgccgtgt    240

tctcctgctc cctctttcct gagaccagtg cagaggctat ggaagtgcgg ttcttcagga    300

atcagttcca tgctgtggtc cacctctaca gagatgggga agactgggaa tctaagcaga    360

tgccacagta tcgagggaga actgagtttg tgaaggactc cattgcaggg gggcgtgtct    420

ctctaaggct aaaaaacatc actccctcgg acatcggcct gtatgggtgc tggttcagtt    480

cccagattta cgatgaggag gccacctggg agctgcgggt ggcagcactg ggctcacttc    540

ctctcatttc catcgtggga tatgttgacg gaggtatcca gttactctgc ctgtcctcat    600

tccagccctc accttggcgc ctggcttcta ttttactcgg gttactctgt ggtgccctgt    660

gtggtgttgt catggggatg ataattgttt tcttcaaatc caaagggaaa atccaggcgg    720

aactgggtat gtgtcatgtc ctgagcctcc cacacatggt tctcccgggt ccctccctga    780

tccacagttt gagcctctgg acgaccctgg ctgcaggctg gacaggaagc accgactgga    840

gaagaaagca cggacaggca gaattgagag acgcccggaa acacgcagtg gaggtgactc    900

tggatccaga gacggctcac ccgaagctct gcgtttctga tctgaaaact gtaacccata    960

gaaaagctcc ccaggaggtg cctcactctg agaagagatt tacaaggaag agtgtggtgg   1020

cttctcaggg tttccaagca gggaaacatt actgggaggt ggacgtggga caaaatgtag   1080

ggtggtatgt gggagtgtgt cgggatgacg tagacagggg gaagaacaat gtgactttgt   1140

ctcccaacaa tgggtattgg gtcctcagac tgacaacaga acatttgtat ttcacattca   1200

atccccattt tatcagcctc ccccccagca cccctcctac acgagtaggg gtcttcctgg   1260

actatgaggg tgggaccatc tccttcttca atacaaatga ccagtccctt atttataccc   1320

tgctgacatg tcagtttgaa ggcttgttga gaccctatat ccagcatgcg atgtatgacg   1380

aggaaaaggg gactcccata ttcatatgtc cagtgtcctg gggatgagac agagaagacc   1440

ctgcttaaag ggccccacac cacagaccca gacacagcca agggagagtg ctcccgacag   1500

gtggccccag cttcctctcc ggagcctgcg cacagagagt cacgcccccc actctccttt   1560

agggagctga ggttcttctg ccctgagccc tgcagcagcg gcagtcacag cttccagatg   1620

aggggggatt ggcctgaccc tgtgggagtc agaagccatg gctgccctga agtggggacg   1680

gaatagactc acattaggtt tagtttgtga aaactccatc cagctaagcg atcttgaaca   1740

agtcacaacc tcccaggctc ctcatttgct agtcacggac agtgattcct gcctcacagg   1800

tgaagattaa agagacaacg aatgtgaatc atgcttgcag gtttgagggc acagtgtttg   1860

ctaatgatgt gtttttatat tatacatttt cccaccataa actctgtttg cttattccac   1920

attaatttac ttttctctat accaaatcac ccatggaata gttattgaac acctgctttg   1980

tgaggctcaa agaataaaga ggaggtagga tttttcactg attctataag cccagcatta   2040

cctgatacca aaaccaggca aagaaaacag aagaagagga aggaaaacta caggtccata   2100

tccctcatta acacagacac aaaaattcta aataaaattt taacaaatta aactaaacaa   2160

tatatttaaa gatgatatat aactactcag tgtggtttgt cccacaaatg cagagttggt   2220

ttaatattta aatatcaacc agtgtaattc agcacattaa taaagtaaaa aagaaaacca   2280

taaaaaaaaa aaaaaa                                                   2296


<210>  1213
<211>  432
<212>  PRT
<213>  Homosapiens

<400>  1213

Met Ala Phe Val Leu Ile Leu Val Leu Ser Phe Tyr Glu Leu Val Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Thr Gly Pro Gly Lys Phe Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Val Phe Ser Cys Ser Leu Phe Pro Glu Thr Ser Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Asn Gln Phe His Ala Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Glu Asp Trp Glu Ser Lys Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Arg Gly Arg Thr Glu Phe Val Lys Asp Ser Ile Ala Gly Gly Arg 
                85                  90                  95      


Val Ser Leu Arg Leu Lys Asn Ile Thr Pro Ser Asp Ile Gly Leu Tyr 
            100                 105                 110         


Gly Cys Trp Phe Ser Ser Gln Ile Tyr Asp Glu Glu Ala Thr Trp Glu 
        115                 120                 125             


Leu Arg Val Ala Ala Leu Gly Ser Leu Pro Leu Ile Ser Ile Val Gly 
    130                 135                 140                 


Tyr Val Asp Gly Gly Ile Gln Leu Leu Cys Leu Ser Ser Phe Gln Pro 
145                 150                 155                 160 


Ser Pro Trp Arg Leu Ala Ser Ile Leu Leu Gly Leu Leu Cys Gly Ala 
                165                 170                 175     


Leu Cys Gly Val Val Met Gly Met Ile Ile Val Phe Phe Lys Ser Lys 
            180                 185                 190         


Gly Lys Ile Gln Ala Glu Leu Gly Met Cys His Val Leu Ser Leu Pro 
        195                 200                 205             


His Met Val Leu Pro Gly Pro Ser Leu Ile His Ser Leu Ser Leu Trp 
    210                 215                 220                 


Thr Thr Leu Ala Ala Gly Trp Thr Gly Ser Thr Asp Trp Arg Arg Lys 
225                 230                 235                 240 


His Gly Gln Ala Glu Leu Arg Asp Ala Arg Lys His Ala Val Glu Val 
                245                 250                 255     


Thr Leu Asp Pro Glu Thr Ala His Pro Lys Leu Cys Val Ser Asp Leu 
            260                 265                 270         


Lys Thr Val Thr His Arg Lys Ala Pro Gln Glu Val Pro His Ser Glu 
        275                 280                 285             


Lys Arg Phe Thr Arg Lys Ser Val Val Ala Ser Gln Gly Phe Gln Ala 
    290                 295                 300                 


Gly Lys His Tyr Trp Glu Val Asp Val Gly Gln Asn Val Gly Trp Tyr 
305                 310                 315                 320 


Val Gly Val Cys Arg Asp Asp Val Asp Arg Gly Lys Asn Asn Val Thr 
                325                 330                 335     


Leu Ser Pro Asn Asn Gly Tyr Trp Val Leu Arg Leu Thr Thr Glu His 
            340                 345                 350         


Leu Tyr Phe Thr Phe Asn Pro His Phe Ile Ser Leu Pro Pro Ser Thr 
        355                 360                 365             


Pro Pro Thr Arg Val Gly Val Phe Leu Asp Tyr Glu Gly Gly Thr Ile 
    370                 375                 380                 


Ser Phe Phe Asn Thr Asn Asp Gln Ser Leu Ile Tyr Thr Leu Leu Thr 
385                 390                 395                 400 


Cys Gln Phe Glu Gly Leu Leu Arg Pro Tyr Ile Gln His Ala Met Tyr 
                405                 410                 415     


Asp Glu Glu Lys Gly Thr Pro Ile Phe Ile Cys Pro Val Ser Trp Gly 
            420                 425                 430         


<210>  1214
<211>  2398
<212>  DNA
<213>  Homosapiens

<400>  1214
ttgacatcgt tcatgaagag cctctccacg gctcctgcgc ctgagacagc tggcctgacc     60

tccaaatcat ccatccaccc ctgctgtcat ctgttttcat agtgtgagat caacccacag    120

gaatatccat ggcttttgtg ctcattttgg ttctcagttt ctacgagctg gtgtcaggac    180

agtggcaagt cactggaccg ggcaagtttg tccaggcctt ggtgggggag gacgccgtgt    240

tctcctgctc cctctttcct gagaccagtg cagaggctat ggaagtgcgg ttcttcagga    300

atcagttcca tgctgtggtc cacctctaca gagatgggga agactgggaa tctaagcaga    360

tgccacagta tcgagggaga actgagtttg tgaaggactc cattgcaggg gggcgtgtct    420

ctctaaggct aaaaaacatc actccctcgg acatcggcct gtatgggtgc tggttcagtt    480

cccagattta cgatgaggag gccacctggg agctgcgggt ggcagcactg ggctcacttc    540

ctctcatttc catcgtggga tatgttgacg gaggtatcca gttactctgc ctgtcctcag    600

gctggttccc ccagcccaca gccaagtgga aaggtccaca aggacaggat ttgtcttcag    660

actccagagc aaatgcagat gggtacagcc tgtatgatgt ggagatctcc attatagtcc    720

aggaaaatgc tgggagcata ttgtgttcca tccaccttgc tgagcagagt catgaggtgg    780

aatccaaggt attgatagga gagacgtttt tccagccctc accttggcgc ctggcttcta    840

ttttactcgg gttactctgt ggtgccctgt gtggtgttgt catggggatg ataattgttt    900

tcttcaaatc caaagggaaa atccaggcgg aactggactg gagaagaaag cacggacagg    960

cagaattgag agacgcccgg aaacacgcag tggaggtgac tctggatcca gagacggctc   1020

acccgaagct ctgcgtttct gatctgaaaa ctgtaaccca tagaaaagct ccccaggagg   1080

tgcctcactc tgagaagaga tttacaagga agagtgtggt ggcttctcag ggtttccaag   1140

cagggaaaca ttactgggag gtggacgtgg gacaaaatgt agggtggtat gtgggagtgt   1200

gtcgggatga cgtagacagg gggaagaaca atgtgacttt gtctcccaac aatgggtatt   1260

gggtcctcag actgacaaca gaacatttgt atttcacatt caatccccat tttatcagcc   1320

tcccccccag cacccctcct acacgagtag gggtcttcct ggactatgag ggtgggacca   1380

tctccttctt caatacaaat gaccagtccc ttatttatac cctgctgaca tgtcagtttg   1440

aaggcttgtt gagaccctat atccagcatg cgatgtatga cgaggaaaag gggactccca   1500

tattcatatg tccagtgtcc tggggatgag acagagaaga ccctgcttaa agggccccac   1560

accacagacc cagacacagc caagggagag tgctcccgac aggtggcccc agcttcctct   1620

ccggagcctg cgcacagaga gtcacgcccc ccactctcct ttagggagct gaggttcttc   1680

tgccctgagc cctgcagcag cggcagtcac agcttccaga tgagggggga ttggcctgac   1740

cctgtgggag tcagaagcca tggctgccct gaagtgggga cggaatagac tcacattagg   1800

tttagtttgt gaaaactcca tccagctaag cgatcttgaa caagtcacaa cctcccaggc   1860

tcctcatttg ctagtcacgg acagtgattc ctgcctcaca ggtgaagatt aaagagacaa   1920

cgaatgtgaa tcatgcttgc aggtttgagg gcacagtgtt tgctaatgat gtgtttttat   1980

attatacatt ttcccaccat aaactctgtt tgcttattcc acattaattt acttttctct   2040

ataccaaatc acccatggaa tagttattga acacctgctt tgtgaggctc aaagaataaa   2100

gaggaggtag gatttttcac tgattctata agcccagcat tacctgatac caaaaccagg   2160

caaagaaaac agaagaagag gaaggaaaac tacaggtcca tatccctcat taacacagac   2220

acaaaaattc taaataaaat tttaacaaat taaactaaac aatatattta aagatgatat   2280

ataactactc agtgtggttt gtcccacaaa tgcagagttg gtttaatatt taaatatcaa   2340

ccagtgtaat tcagcacatt aataaagtaa aaaagaaaac cataaaaaaa aaaaaaaa     2398


<210>  1215
<211>  466
<212>  PRT
<213>  Homosapiens

<400>  1215

Met Ala Phe Val Leu Ile Leu Val Leu Ser Phe Tyr Glu Leu Val Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Thr Gly Pro Gly Lys Phe Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Val Phe Ser Cys Ser Leu Phe Pro Glu Thr Ser Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Asn Gln Phe His Ala Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Glu Asp Trp Glu Ser Lys Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Arg Gly Arg Thr Glu Phe Val Lys Asp Ser Ile Ala Gly Gly Arg 
                85                  90                  95      


Val Ser Leu Arg Leu Lys Asn Ile Thr Pro Ser Asp Ile Gly Leu Tyr 
            100                 105                 110         


Gly Cys Trp Phe Ser Ser Gln Ile Tyr Asp Glu Glu Ala Thr Trp Glu 
        115                 120                 125             


Leu Arg Val Ala Ala Leu Gly Ser Leu Pro Leu Ile Ser Ile Val Gly 
    130                 135                 140                 


Tyr Val Asp Gly Gly Ile Gln Leu Leu Cys Leu Ser Ser Gly Trp Phe 
145                 150                 155                 160 


Pro Gln Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser 
                165                 170                 175     


Ser Asp Ser Arg Ala Asn Ala Asp Gly Tyr Ser Leu Tyr Asp Val Glu 
            180                 185                 190         


Ile Ser Ile Ile Val Gln Glu Asn Ala Gly Ser Ile Leu Cys Ser Ile 
        195                 200                 205             


His Leu Ala Glu Gln Ser His Glu Val Glu Ser Lys Val Leu Ile Gly 
    210                 215                 220                 


Glu Thr Phe Phe Gln Pro Ser Pro Trp Arg Leu Ala Ser Ile Leu Leu 
225                 230                 235                 240 


Gly Leu Leu Cys Gly Ala Leu Cys Gly Val Val Met Gly Met Ile Ile 
                245                 250                 255     


Val Phe Phe Lys Ser Lys Gly Lys Ile Gln Ala Glu Leu Asp Trp Arg 
            260                 265                 270         


Arg Lys His Gly Gln Ala Glu Leu Arg Asp Ala Arg Lys His Ala Val 
        275                 280                 285             


Glu Val Thr Leu Asp Pro Glu Thr Ala His Pro Lys Leu Cys Val Ser 
    290                 295                 300                 


Asp Leu Lys Thr Val Thr His Arg Lys Ala Pro Gln Glu Val Pro His 
305                 310                 315                 320 


Ser Glu Lys Arg Phe Thr Arg Lys Ser Val Val Ala Ser Gln Gly Phe 
                325                 330                 335     


Gln Ala Gly Lys His Tyr Trp Glu Val Asp Val Gly Gln Asn Val Gly 
            340                 345                 350         


Trp Tyr Val Gly Val Cys Arg Asp Asp Val Asp Arg Gly Lys Asn Asn 
        355                 360                 365             


Val Thr Leu Ser Pro Asn Asn Gly Tyr Trp Val Leu Arg Leu Thr Thr 
    370                 375                 380                 


Glu His Leu Tyr Phe Thr Phe Asn Pro His Phe Ile Ser Leu Pro Pro 
385                 390                 395                 400 


Ser Thr Pro Pro Thr Arg Val Gly Val Phe Leu Asp Tyr Glu Gly Gly 
                405                 410                 415     


Thr Ile Ser Phe Phe Asn Thr Asn Asp Gln Ser Leu Ile Tyr Thr Leu 
            420                 425                 430         


Leu Thr Cys Gln Phe Glu Gly Leu Leu Arg Pro Tyr Ile Gln His Ala 
        435                 440                 445             


Met Tyr Asp Glu Glu Lys Gly Thr Pro Ile Phe Ile Cys Pro Val Ser 
    450                 455                 460                 


Trp Gly 
465     


<210>  1216
<211>  2819
<212>  DNA
<213>  Homosapiens

<400>  1216
atcattgtct atgatatctg caatggaaat gatcactagg caatttcagc cttgcaaatc     60

taacatccag ataccaacct caccatcgtc tgactactat gtccctggtg cacaatgcct    120

gccttcacta cagcctttca cacaaagtat ttaccctgtt gcttaattgt ctgatcgtcc    180

cactcccttg gatgagaact gcatctcttc catctcttat tctgagtggc ttggctaaga    240

cattcactga ctccatgggg aaacttcacc tacagaggaa agagccatcc tcctgtgggc    300

aggtgatgtg tccttgttct ttccctgacg tgcccagtcc tcttgcaagt gacttgaaag    360

gatgcaccag cctggctgca ggcagaggtg tgaagaaggt ccttgcttcc ccttcacctt    420

ctgccatgat tctaagtttc ctgacgcctc ccagccgtgc ttcctgttaa gcctgtgaaa    480

ctcctttgga atgagtacac atccaggagt gaagaagaca agctcaactg ccattctctg    540

agcagttcaa ggcatactga gttgcgggag ttgtgtggtg gtccactctg actgcaagca    600

cccctttctt gaaccgaaca gagtcaagtg gaatcaaagg acattacctg ttgattcttg    660

ggcaaggccc agaatttggt ggacatactt aaagaagaaa ggaatcttca gctaaagtgt    720

ctacgatcaa ttcagatttg gagggcatgg atcttctgac agtaggggcc attctaggat    780

tttttggttg aagagatgaa cttcaacttg gttccagatg ggtggtccag ctattctgct    840

gacaacattt ttcagggcaa ggcttttgct actggaatga tttaaggaag atccctcagt    900

gtttcagagt aaagatattt ctaaagaagt acctgtgtca ttgcccatct tgaagattga    960

cttttatgga ttgctcaaat actgatatca gctcaatgtc aatatatact cctacatata   1020

aaatccatct tctaatcata atcactaggt ggatattgtt atgcaaggaa gagatgtgaa   1080

tatacaggaa atgagatcct taaaggggtt gccgtccaga tgttagatca aagagattat   1140

gattcattca accaagtcgc tggacttttg aaggcctatc caagtcatgg tgcctttgag   1200

gttgcgcctg ttactattca aaacttggta tgtgttattc catgtaaatg ttatgcaatg   1260

attcaaaaat gaataccagg ttgaaagatg ttataacagc cccttgttcc aatgaactct   1320

acctttgtga gcaaaggtga ccaaaaagac cacactgcat gaccagcagc ccacaaacca   1380

gactgggcta agttctgctg ctatctctag agcttgctgc tgttcaaagc actccttggg   1440

tccagccaga ttgccatact ttcttgatgt atttcccatg gctgcttcat ttgttgttca   1500

tttctcttag tgcttttagt aggttattgt tttaggtggc gtatctgtac ctcctcataa   1560

aagatttttg ggtccacatt ttccactcaa aatcatagta gccatgatga acacctggca   1620

tcctttggac aactttccat aactacataa taatgagcca gtttttacca tccatattag   1680

atatggctag agtgactatt ttctgaatca aaattgtgct gagcatttgc caaatatcag   1740

ataaacttaa agccctagaa gtatcttaga aagtccaagg ggagtgtcat tgttctagac   1800

ttagttcaaa agatgctaga caatggcgtc caagttcagc ctttgtagac atatagagtg   1860

aacattaccc ttgctgttat aggttttatt ctccactgag ggccacagag cctcaccatt   1920

ggtttgcccc acacacaaca gggtaaattc ctactccttt gtcaattagg aattttccag   1980

gcaatgtgtt tacctcttgg gtaaatacat tactttcatc agtgtaactt aactataaag   2040

tatttttaga ggatcagatt atttgagtat ggctgtgata agtctctcct taaatggacc   2100

ttaacaaagt agaaagaaaa cgttagcaga catttcagac taatgatgtt ttcttttttt   2160

caagtgggtt atttagagtt gaatagcaat tacttaaagc tagtagcaaa ggaacatttt   2220

ctgtaatgat gtttatttat gccttttcat tctataacat tcagcatgtg acaaaggaat   2280

tagagaaaag actagtcgaa tctggagcca tgcaattaat gaaatccata tgtttgaaga   2340

aatcgtctta tataactccc atgcttctga tatttcctag aacgtcttag attgaggtca   2400

ttgtgcacta ttaacagagt cctggttaat aatgtacaat gaccttaatt cagcatgttt   2460

ttaatgaata gctgaacttc atgcttataa catcctgact atgcttacaa atatttttct   2520

aaattgctgg tctgtttgca gatgcattat cagtgcatgc aaaaaataag attatgcctc   2580

gtttaggatt ctctttcttg taaagtccaa tcactgctgc attaagatag gtatgggaat   2640

gtgtaggcaa agtcacatat agtgacacac attggataaa aaatataaac ttcagccaca   2700

tgattctttc actcaaaaac ataatgtggc tctcctttat atcttttttt aatgatttgc   2760

atagctttcc attgtgtgta tgtgctataa tttgttttaa taaaccccca ctaattgat    2819


<210>  1217
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  1217

Met Ser Leu Val His Asn Ala Cys Leu His Tyr Ser Leu Ser His Lys 
1               5                   10                  15      


Val Phe Thr Leu Leu Leu Asn Cys Leu Ile Val Pro Leu Pro Trp Met 
            20                  25                  30          


Arg Thr Ala Ser Leu Pro Ser Leu Ile Leu Ser Gly Leu Ala Lys Thr 
        35                  40                  45              


Phe Thr Asp Ser Met Gly Lys Leu His Leu Gln Arg Lys Glu Pro Ser 
    50                  55                  60                  


Ser Cys Gly Gln Val Met Cys Pro Cys Ser Phe Pro Asp Val Pro Ser 
65                  70                  75                  80  


Pro Leu Ala Ser Asp Leu Lys Gly Cys Thr Ser Leu Ala Ala Gly Arg 
                85                  90                  95      


Gly Val Lys Lys Val Leu Ala Ser Pro Ser Pro Ser Ala Met Ile Leu 
            100                 105                 110         


Ser Phe Leu Thr Pro Pro Ser Arg Ala Ser Cys 
        115                 120             


<210>  1218
<211>  895
<212>  DNA
<213>  Homosapiens

<400>  1218
ttatttttct gtgtgtccca tacaggcccc caccatgaag ggtttcacag ccactctctt     60

cctctggact ctgatttttc ccagctgcag tggaggcggc ggtgggaaag cctggcccac    120

acacgtggtc tgtagcgaca gcggcttgga agtgctctac cagagttgcg atccattaca    180

agattttggc ttttctgttg aaaagtgttc caagcaatta aaatcaaata tcaacattag    240

atttggaatt attctgagag aggacatcaa agagcttttt cttgacctag ctctcatgtc    300

tcaaggctca tctgttttga atttctccta tcccatctgt gaggcggctc tgcccaagtt    360

ttctttctgt ggaagaagga aaggagagca gatttactat gctgggcctg tcaataatcc    420

tgaatttact attcctcagg gagaatacca ggttttgctg gaactgtaca ctgaaaaacg    480

gtccaccgtg gcctgtgcca atgctactat catgtgctcc tgactgtggc ctgtagcaaa    540

aatcacagcc agctgcatct cgtgggacct ccaagctcct ctgactgaac ctactgtggg    600

aggagaagca gctgatgaca gagagaggct ctacaaagaa gcgcccccaa agagtgcagc    660

tgctaatttt agtcccagga ccagacatcc ccagactcca cagatgtaat gaagtccccg    720

aatgtatctg tttctaagga gcctcttggc agtccttaag cagtcttgag ggtccatcct    780

ttttctctaa ttggtcgcct cccaccagac tcacctgctt ttcaactttt taggagtgct    840

tcctcacagt taccaagaat aaagaaagct ggccaccata aaaaaaaaaa aaaaa         895


<210>  1219
<211>  162
<212>  PRT
<213>  Homosapiens

<400>  1219

Met Lys Gly Phe Thr Ala Thr Leu Phe Leu Trp Thr Leu Ile Phe Pro 
1               5                   10                  15      


Ser Cys Ser Gly Gly Gly Gly Gly Lys Ala Trp Pro Thr His Val Val 
            20                  25                  30          


Cys Ser Asp Ser Gly Leu Glu Val Leu Tyr Gln Ser Cys Asp Pro Leu 
        35                  40                  45              


Gln Asp Phe Gly Phe Ser Val Glu Lys Cys Ser Lys Gln Leu Lys Ser 
    50                  55                  60                  


Asn Ile Asn Ile Arg Phe Gly Ile Ile Leu Arg Glu Asp Ile Lys Glu 
65                  70                  75                  80  


Leu Phe Leu Asp Leu Ala Leu Met Ser Gln Gly Ser Ser Val Leu Asn 
                85                  90                  95      


Phe Ser Tyr Pro Ile Cys Glu Ala Ala Leu Pro Lys Phe Ser Phe Cys 
            100                 105                 110         


Gly Arg Arg Lys Gly Glu Gln Ile Tyr Tyr Ala Gly Pro Val Asn Asn 
        115                 120                 125             


Pro Glu Phe Thr Ile Pro Gln Gly Glu Tyr Gln Val Leu Leu Glu Leu 
    130                 135                 140                 


Tyr Thr Glu Lys Arg Ser Thr Val Ala Cys Ala Asn Ala Thr Ile Met 
145                 150                 155                 160 


Cys Ser 
        


<210>  1220
<211>  7370
<212>  DNA
<213>  Homosapiens

<400>  1220
atgccaggga gccaagcgtc ctgcccggcc gttgctccga ctgtgtgttc caggagtggt     60

ggctctgagg tgtgaccctg cccacgtttg ggcccagcca ggttcagccc cccaataagg    120

agggcagctt gataacacaa agaaaacagt gtcaacgagt actaccaaga gaagaagaca    180

agaggtcaac acagactcat tttctactcc gtgtgaatga tagctacagc aggggaaagt    240

ttcatagtct atcagtgggt cagaaaatgg agttttatag cagaggcttc ttagaagctt    300

aaacccctgt cccaatgacg tcaagttcgc ccgctggctt ggaaggttca gacctatctt    360

ccatcaacac catgatgtcg gcggtcatga gtgtagggaa ggtcacagag aatggcggga    420

gcccccaggg gatcaagtcc ccctcgaagc ctccaggacc aaatcggatt ggcagaagga    480

accaggaaac gaaagaggag aagtcttcct ataactgccc cctgtgtgag aagatttgca    540

ctacccagca ccagctgacc atgcacattc gccagcacaa cacagacact ggaggagccg    600

accactcatg cagcatctgc ggaaagtcac tgagctcggc cagctccctc gatcgccaca    660

tgctggtgca ctctggcgag aggccttaca agtgcactgt gtgtggccag tcatttacca    720

ccaatgggaa catgcacaga catatgaaga tccatgagaa ggaccctaac agtgccacag    780

ccacagcccc tccatctcct ctgaaacgta ggcgattgtc ctccaagagg aaactgagtc    840

acgatgccga gtcagagaga gaagacccag caccagctaa aaagatggta gaagacgggc    900

agtcaggtga cttggagaag aaagctgatg aagtctttca ctgcccagta tgtttcaagg    960

agtttgtttg caagtatgga ctggagaccc acatggagac ccattcagat aacccactaa   1020

gatgtgacat ttgttgtgtc acctttcgaa cacatcgagg actgctgcgt cacaacgcgc   1080

ttgtccacaa acaacttccc agggatgcaa tgggcagacc tttcatacag aacaaccctt   1140

caattcctgc tggcttccac gacttaggat tcacggactt ctcctgtagg aagtttcctc   1200

gcatttctca ggcctggtgc gaaacaaacc tgcggaggtg catcagcgag caacaccgtt   1260

ttgtctgcga cacctgtgac aaggcgttcc ccatgctctg ctcactggct ctgcacaagc   1320

agacccatgt ggcggcagac cagggtcaag aaaagccgca ggccacgccc ctgcctggtg   1380

acgccctgga ccagaagggc ttcctggcct tgcttggcct gcagcacacc aaagacgtca   1440

ggcctgcccc cgccgaggag cccctgccgg atgacaacca ggcaattcag ctccagacac   1500

tcaagtgtca gctacctcag gaccccggct gcaccaacct gctgagcctg tcacctttcg   1560

aagctgcttc cctaggcggt tctctcacag ttctccccgc gaccaaggac agcataaagc   1620

acctgtccct gcagcccttc cagaagggct tcatcatcca gcctgacagc agcattgtgg   1680

tcaagcccat ctctggcgag tcggccatcg agctggcaga catccagcaa attctgaaga   1740

tggcagcctc ggctccccct cagatcagtc ttccgccctt ctccaaggcc cctgccgccc   1800

cactgcaggc gatcttcaag cacatgcccc ctctgaagcc aaagcccctg gtcacaccac   1860

ggacggtggt ggccacctcc acgcccccgc ctctcatcaa cgcccagcag gcttccccgg   1920

gctgtatcag ccccagcctg ccgccaccgc ccctgaagct cctcaaaggc tcagtggagg   1980

cggcctccaa cgcccacctg ctgcagtcca agtccgggac ccagccccac gcggccacgc   2040

ggctctccct gcagcagccg cgggcggagc tgccgggcca gcctgagatg aagacgcagc   2100

tggagcagga cagcatcatc gaggccctgc tgccgctgag catggaggcc aagatcaagc   2160

aggagatcac agagggggaa ctcaaggcct tcatgacagc gcccggcggc aagaagacgc   2220

ccgccatgcg caaggtgctc tacccctgcc gcttctgcaa ccaggtgttt gccttctcgg   2280

gggtcttgcg tgcccacgtg cgctcccacc tgggcatctc gccataccag tgcaacatct   2340

gcgactacat cgccgccgac aaggccgcgc tcatccgcca cctgcgcacg cacagtgggg   2400

agcggcccta catttgcaag atctgccact accccttcac tgtcaaagcc aactgcgagc   2460

ggcacctgcg caagaagcac ctcaaggcca cccgcaagga tatcgagaag aacatcgagt   2520

atgtgagtag cagcgcggcc gagctggtgg acgccttctg cgccccggac accgtgtgcc   2580

ggctgtgcgg cgaggacctc aagcactatc gtgccctgcg catccacatg cgcacgcact   2640

gcggccgcgg cctgggcggg ggccacaagg gccgcaagcc cttcgagtgc aaggagtgca   2700

gcgccgcgtt cgcggccaag cgcaactgca tccaccacat cctcaagcag cacctgcacg   2760

tgcccgagca ggacatcgag agctacgtgc tggccgccga cggcctgggc cccgcagagg   2820

cgccggccgc tgaggcgtcg gggcgcgggg aggacagtgg ctgcgctgcc cttggtgact   2880

gcaagcccct cactgccttc ctggaacccc agaacggctt tcttcacagg ggccccaccc   2940

agcctccacc tccccatgtc tcgatcaagt tggagcccgc cagtagcttt gcggtggact   3000

tcaatgagcc cctggacttc tcgcagaagg gcctggccct ggtccaagtg aagcaggaaa   3060

acatctcctt tctgagccct tcttccctgg tcccctatga ctgctccatg gagcccatcg   3120

acctgtccat ccccaagaac ttcaggaaag gggacaagga tttggccact cccagcgaag   3180

ccaagaagcc tgaggaggag gcggggagca gcgagcagcc ctctccctgc ccagcacccg   3240

gcccttctct tcctgtaact ttggggccca gcggaatcct ggaaagcccc atggcccctg   3300

ctccggcggc caccccggaa cccccagcac agcccctgca gggccctgtt cagctggcgg   3360

tcccaatcta ctcctcagcc ctggtcagca gccctccact cgtgggcagc tcagccctcc   3420

tgagtggcac agccttgctg cgtccactgc ggcccaagcc cccgctgctt ttgccaaagc   3480

cccccgtgac agaagagctg cccccgctgg cctccattgc ccagatcatc tcatctgtat   3540

cctcggcccc caccctgctg aaaaccaagg tggcggaccc agggcccgca agcactggca   3600

gtaacaccac ggcttcagac agcttaggag gttctgtccc caaagccgcc accaccgcca   3660

cccccgctgc caccaccagc ccaaaagagt ctagtgagcc tcccgctcca gccagcagcc   3720

cagaggctgc ctctcccacc gagcagggcc cagcgggcac gtcgaagaag aggggccgga   3780

aaagggggat gaggagccga ccccgcgcca acagcggcgg ggtggacctg gactccagcg   3840

gggagtttgc cagcatcgag aagatgctgg ccaccacaga caccaacaag ttcagtccgt   3900

ttctgcagac agcggaggac aacactcagg atgaggtggc cggagcccct gccgaccacc   3960

atgggcccag tgatgaagag cagggcagtc ccccagaaga caagctgctg agggccaagc   4020

ggaactcgta caccaactgc ctgcagaaga tcacctgtcc ccactgtccc cgggttttcc   4080

cttgggccag ctccctacag aggcacatgc tcacacacac tgacagtcag tcggatgcgg   4140

agactgcagc cgccgcgggc gaagtgctag acctcacctc acgggacaga gagcagccgt   4200

cggagggcgc cactgagctc cgccaggtcg caggggatgc gcctgtggag caggccacgg   4260

cggaaacggc ctcgccggtg caccgggaag agcacgggcg tggggagagc catgagccgg   4320

aggaggagca tggcactgag gagagcactg gggacgccga cggcgcggaa gaggacgcgt   4380

cgagcaacca gagcctggac ctggacttcg ccaccaagct catggacttc aagctggcgg   4440

agggcgacgg cgaggcaggc gccgggggcg cggcctcgca ggagcagaag ctcgcctgcg   4500

acacctgtgg gaagagcttc aagttcctgg gcaccctgag ccgccaccgg aaggcgcacg   4560

gccgccagga gcccaaggac gagaagggag atggcgccag cactgcagag gaggggcccc   4620

agcccgcccc tgaacaggag gagaagcccc ccgagacccc ggcagaggtg gtggagtcgg   4680

ccccgggtgc cggggaggcc ccggcggaaa agctcgcgga ggagacggag ggcccctccg   4740

acggggagag cgcggccgag aaaaggtcct cagagaagag cgacgatgac aagaaaccaa   4800

agacagactc ccccaaaagc gtggccagca aggcagacaa gaggaagaag gtctgcagcg   4860

tgtgcaacaa gcggttctgg tcgctgcagg acctgacccg gcacatgcgc tcccacacag   4920

gggaaaggcc atacaaatgt cagacctgcg agcgaacctt caccttgaag cacagcctgg   4980

ttcgccacca gcggatccac cagaaagcca ggcatgccaa acaccacggg aaggacagcg   5040

acaaggaaga gcggggtgag gaggacagcg agaatgagtc cacccacagc ggcaacaacg   5100

ccgtctcaga gaacgaggct gagctggctc ccaatgccag caaccacatg gctgtcaccc   5160

ggagccggaa ggagggcttg gccagtgcca ccaaggactg cagccacagg gaggagaagg   5220

tcacggcagg gtggccgtct gagcctggcc agggtgacct taacccagag agcccggcgg   5280

ccctggggca ggacctgctg gagccgcgca gcaagaggcc tgcccaccca atcctggcca   5340

cagctgatgg cgcctcccag ctcgtgggga tggagtgaca gcctcagtcc ccctcagcac   5400

agacaaaagc cagcagagca aagcgtctat acttcatggg gtttcctcag tgccctttgg   5460

ctgttgagga gtgagagaga gagagagaga gagagagaga gagagagaga gacaagcagg   5520

agcgtggctg ctcgctcagt gccatagcct taccgcagcc tgcgcgggag gccacagccc   5580

gtgccgattc cagtgcctta actacttacc ggatccctcc atattatcat gggtgttgta   5640

tttttccaaa atgacttctt aaacaaaaca aatattataa tgaattgtct ggagaggacc   5700

tcttcatttg agcattagcg ttattttgta ttggtgtgtg tgagcttgtt cttgtgaatc   5760

tgtgatagca ccgtttgttc tgtgagctgg aaacagaagg aaaaaacata cccttgggta   5820

cccatagcca ataactggaa gaaaatgatg tgaatttcat gtaaatgacc agaggaaaga   5880

tggataagat gataatttct taaatagaca ttttcctttt ttctttgtgc ttcatggtgg   5940

agctgtcatc tggtccttgg tattacagga tgtggttgat gaaggtttcc aatatggttt   6000

caggccaaaa ccagggaaga ttctagcttc agcctcatgt ccatttccag tctgtcagca   6060

ttagacatgg tcactgttca agtttcaaga catccattct taactataga gaagagttac   6120

tcccctggcg tcttaaccta tggaaaacat gcacggatag gatatatttg attgcctcct   6180

cttccctttc agtatatgta ttattaatat tattattatt attattatta ttagttcatc   6240

agtttgctgt tctctgcagt gagcagaatc aaatgggcaa tatttgtcct gggagacctg   6300

tgccgcaccc aggtccccgt gttaacgtgt gcctgcggtt gtggttggca ccctcgggtg   6360

gtagctcttc tactgtaatg agacaagcct ttcttctgtc actgcagaat ttagaagggg   6420

ccgtgagcag tcttcccaag catggtccag gagcagctca gagagggtgg agtgaggatg   6480

catgcatcca gggaacaggc atcaagaagc cagggccgtg cctggagcac tgcagagatg   6540

actttggaga aagcaaagca gtgacccagt gaccaggcac attactcgtg agcgaggtat   6600

tcccagtctt cctgctaagc ctaatccaag ccttacccag ctgtgctact gtcatttgca   6660

aagcaaggaa atactactac tggtaataaa actacactag caagatgtca gataagaaat   6720

aggtttatat ttaccttcct gcgatgtggg gttggtgctt gaagataaat gtgctgtttc   6780

tagtttctta aatagcccac acccctggat gcaaaaaggc agggttattt ttacccatga   6840

gcatcctgtg caggcaatag acttccctca ctgtctccgc ctgcagggag gagaatgtac   6900

cccactgcac ctgagctcct ggtccctcag ccaagacctc aggggtcccc agccagcctg   6960

ctgctgggga cccctgtgct tgctgcagtg tatggagcct cttgccttcc cctggggagg   7020

cacccctgta ccccagcttc cttcccctgg ccttttctgg ccccagtgct cctcctttac   7080

atagacttgt tcacacagaa acgtgcacgc ccccttttct ccgccacttc accagtttct   7140

gaaatccaac ctcccagact tcacaggaag atagatattc ttgagataat gaaaagtgat   7200

atcttcgcat acgaaaggaa aaaaggttga ggtatatatg atttttaact gtattagggg   7260

tgtatgaacc agtttaaaaa cgaggtttta tttactgtag agatgaatgc aaatcagaac   7320

caatgatccc ttggcctact tagttaaaac cagttcatac atcccttagg              7370


<210>  1221
<211>  1687
<212>  PRT
<213>  Homosapiens

<400>  1221

Met Thr Ser Ser Ser Pro Ala Gly Leu Glu Gly Ser Asp Leu Ser Ser 
1               5                   10                  15      


Ile Asn Thr Met Met Ser Ala Val Met Ser Val Gly Lys Val Thr Glu 
            20                  25                  30          


Asn Gly Gly Ser Pro Gln Gly Ile Lys Ser Pro Ser Lys Pro Pro Gly 
        35                  40                  45              


Pro Asn Arg Ile Gly Arg Arg Asn Gln Glu Thr Lys Glu Glu Lys Ser 
    50                  55                  60                  


Ser Tyr Asn Cys Pro Leu Cys Glu Lys Ile Cys Thr Thr Gln His Gln 
65                  70                  75                  80  


Leu Thr Met His Ile Arg Gln His Asn Thr Asp Thr Gly Gly Ala Asp 
                85                  90                  95      


His Ser Cys Ser Ile Cys Gly Lys Ser Leu Ser Ser Ala Ser Ser Leu 
            100                 105                 110         


Asp Arg His Met Leu Val His Ser Gly Glu Arg Pro Tyr Lys Cys Thr 
        115                 120                 125             


Val Cys Gly Gln Ser Phe Thr Thr Asn Gly Asn Met His Arg His Met 
    130                 135                 140                 


Lys Ile His Glu Lys Asp Pro Asn Ser Ala Thr Ala Thr Ala Pro Pro 
145                 150                 155                 160 


Ser Pro Leu Lys Arg Arg Arg Leu Ser Ser Lys Arg Lys Leu Ser His 
                165                 170                 175     


Asp Ala Glu Ser Glu Arg Glu Asp Pro Ala Pro Ala Lys Lys Met Val 
            180                 185                 190         


Glu Asp Gly Gln Ser Gly Asp Leu Glu Lys Lys Ala Asp Glu Val Phe 
        195                 200                 205             


His Cys Pro Val Cys Phe Lys Glu Phe Val Cys Lys Tyr Gly Leu Glu 
    210                 215                 220                 


Thr His Met Glu Thr His Ser Asp Asn Pro Leu Arg Cys Asp Ile Cys 
225                 230                 235                 240 


Cys Val Thr Phe Arg Thr His Arg Gly Leu Leu Arg His Asn Ala Leu 
                245                 250                 255     


Val His Lys Gln Leu Pro Arg Asp Ala Met Gly Arg Pro Phe Ile Gln 
            260                 265                 270         


Asn Asn Pro Ser Ile Pro Ala Gly Phe His Asp Leu Gly Phe Thr Asp 
        275                 280                 285             


Phe Ser Cys Arg Lys Phe Pro Arg Ile Ser Gln Ala Trp Cys Glu Thr 
    290                 295                 300                 


Asn Leu Arg Arg Cys Ile Ser Glu Gln His Arg Phe Val Cys Asp Thr 
305                 310                 315                 320 


Cys Asp Lys Ala Phe Pro Met Leu Cys Ser Leu Ala Leu His Lys Gln 
                325                 330                 335     


Thr His Val Ala Ala Asp Gln Gly Gln Glu Lys Pro Gln Ala Thr Pro 
            340                 345                 350         


Leu Pro Gly Asp Ala Leu Asp Gln Lys Gly Phe Leu Ala Leu Leu Gly 
        355                 360                 365             


Leu Gln His Thr Lys Asp Val Arg Pro Ala Pro Ala Glu Glu Pro Leu 
    370                 375                 380                 


Pro Asp Asp Asn Gln Ala Ile Gln Leu Gln Thr Leu Lys Cys Gln Leu 
385                 390                 395                 400 


Pro Gln Asp Pro Gly Cys Thr Asn Leu Leu Ser Leu Ser Pro Phe Glu 
                405                 410                 415     


Ala Ala Ser Leu Gly Gly Ser Leu Thr Val Leu Pro Ala Thr Lys Asp 
            420                 425                 430         


Ser Ile Lys His Leu Ser Leu Gln Pro Phe Gln Lys Gly Phe Ile Ile 
        435                 440                 445             


Gln Pro Asp Ser Ser Ile Val Val Lys Pro Ile Ser Gly Glu Ser Ala 
    450                 455                 460                 


Ile Glu Leu Ala Asp Ile Gln Gln Ile Leu Lys Met Ala Ala Ser Ala 
465                 470                 475                 480 


Pro Pro Gln Ile Ser Leu Pro Pro Phe Ser Lys Ala Pro Ala Ala Pro 
                485                 490                 495     


Leu Gln Ala Ile Phe Lys His Met Pro Pro Leu Lys Pro Lys Pro Leu 
            500                 505                 510         


Val Thr Pro Arg Thr Val Val Ala Thr Ser Thr Pro Pro Pro Leu Ile 
        515                 520                 525             


Asn Ala Gln Gln Ala Ser Pro Gly Cys Ile Ser Pro Ser Leu Pro Pro 
    530                 535                 540                 


Pro Pro Leu Lys Leu Leu Lys Gly Ser Val Glu Ala Ala Ser Asn Ala 
545                 550                 555                 560 


His Leu Leu Gln Ser Lys Ser Gly Thr Gln Pro His Ala Ala Thr Arg 
                565                 570                 575     


Leu Ser Leu Gln Gln Pro Arg Ala Glu Leu Pro Gly Gln Pro Glu Met 
            580                 585                 590         


Lys Thr Gln Leu Glu Gln Asp Ser Ile Ile Glu Ala Leu Leu Pro Leu 
        595                 600                 605             


Ser Met Glu Ala Lys Ile Lys Gln Glu Ile Thr Glu Gly Glu Leu Lys 
    610                 615                 620                 


Ala Phe Met Thr Ala Pro Gly Gly Lys Lys Thr Pro Ala Met Arg Lys 
625                 630                 635                 640 


Val Leu Tyr Pro Cys Arg Phe Cys Asn Gln Val Phe Ala Phe Ser Gly 
                645                 650                 655     


Val Leu Arg Ala His Val Arg Ser His Leu Gly Ile Ser Pro Tyr Gln 
            660                 665                 670         


Cys Asn Ile Cys Asp Tyr Ile Ala Ala Asp Lys Ala Ala Leu Ile Arg 
        675                 680                 685             


His Leu Arg Thr His Ser Gly Glu Arg Pro Tyr Ile Cys Lys Ile Cys 
    690                 695                 700                 


His Tyr Pro Phe Thr Val Lys Ala Asn Cys Glu Arg His Leu Arg Lys 
705                 710                 715                 720 


Lys His Leu Lys Ala Thr Arg Lys Asp Ile Glu Lys Asn Ile Glu Tyr 
                725                 730                 735     


Val Ser Ser Ser Ala Ala Glu Leu Val Asp Ala Phe Cys Ala Pro Asp 
            740                 745                 750         


Thr Val Cys Arg Leu Cys Gly Glu Asp Leu Lys His Tyr Arg Ala Leu 
        755                 760                 765             


Arg Ile His Met Arg Thr His Cys Gly Arg Gly Leu Gly Gly Gly His 
    770                 775                 780                 


Lys Gly Arg Lys Pro Phe Glu Cys Lys Glu Cys Ser Ala Ala Phe Ala 
785                 790                 795                 800 


Ala Lys Arg Asn Cys Ile His His Ile Leu Lys Gln His Leu His Val 
                805                 810                 815     


Pro Glu Gln Asp Ile Glu Ser Tyr Val Leu Ala Ala Asp Gly Leu Gly 
            820                 825                 830         


Pro Ala Glu Ala Pro Ala Ala Glu Ala Ser Gly Arg Gly Glu Asp Ser 
        835                 840                 845             


Gly Cys Ala Ala Leu Gly Asp Cys Lys Pro Leu Thr Ala Phe Leu Glu 
    850                 855                 860                 


Pro Gln Asn Gly Phe Leu His Arg Gly Pro Thr Gln Pro Pro Pro Pro 
865                 870                 875                 880 


His Val Ser Ile Lys Leu Glu Pro Ala Ser Ser Phe Ala Val Asp Phe 
                885                 890                 895     


Asn Glu Pro Leu Asp Phe Ser Gln Lys Gly Leu Ala Leu Val Gln Val 
            900                 905                 910         


Lys Gln Glu Asn Ile Ser Phe Leu Ser Pro Ser Ser Leu Val Pro Tyr 
        915                 920                 925             


Asp Cys Ser Met Glu Pro Ile Asp Leu Ser Ile Pro Lys Asn Phe Arg 
    930                 935                 940                 


Lys Gly Asp Lys Asp Leu Ala Thr Pro Ser Glu Ala Lys Lys Pro Glu 
945                 950                 955                 960 


Glu Glu Ala Gly Ser Ser Glu Gln Pro Ser Pro Cys Pro Ala Pro Gly 
                965                 970                 975     


Pro Ser Leu Pro Val Thr Leu Gly Pro Ser Gly Ile Leu Glu Ser Pro 
            980                 985                 990         


Met Ala Pro Ala Pro Ala Ala Thr  Pro Glu Pro Pro Ala  Gln Pro Leu 
        995                 1000                 1005             


Gln Gly  Pro Val Gln Leu Ala  Val Pro Ile Tyr Ser  Ser Ala Leu 
    1010                 1015                 1020             


Val Ser  Ser Pro Pro Leu Val  Gly Ser Ser Ala Leu  Leu Ser Gly 
    1025                 1030                 1035             


Thr Ala  Leu Leu Arg Pro Leu  Arg Pro Lys Pro Pro  Leu Leu Leu 
    1040                 1045                 1050             


Pro Lys  Pro Pro Val Thr Glu  Glu Leu Pro Pro Leu  Ala Ser Ile 
    1055                 1060                 1065             


Ala Gln  Ile Ile Ser Ser Val  Ser Ser Ala Pro Thr  Leu Leu Lys 
    1070                 1075                 1080             


Thr Lys  Val Ala Asp Pro Gly  Pro Ala Ser Thr Gly  Ser Asn Thr 
    1085                 1090                 1095             


Thr Ala  Ser Asp Ser Leu Gly  Gly Ser Val Pro Lys  Ala Ala Thr 
    1100                 1105                 1110             


Thr Ala  Thr Pro Ala Ala Thr  Thr Ser Pro Lys Glu  Ser Ser Glu 
    1115                 1120                 1125             


Pro Pro  Ala Pro Ala Ser Ser  Pro Glu Ala Ala Ser  Pro Thr Glu 
    1130                 1135                 1140             


Gln Gly  Pro Ala Gly Thr Ser  Lys Lys Arg Gly Arg  Lys Arg Gly 
    1145                 1150                 1155             


Met Arg  Ser Arg Pro Arg Ala  Asn Ser Gly Gly Val  Asp Leu Asp 
    1160                 1165                 1170             


Ser Ser  Gly Glu Phe Ala Ser  Ile Glu Lys Met Leu  Ala Thr Thr 
    1175                 1180                 1185             


Asp Thr  Asn Lys Phe Ser Pro  Phe Leu Gln Thr Ala  Glu Asp Asn 
    1190                 1195                 1200             


Thr Gln  Asp Glu Val Ala Gly  Ala Pro Ala Asp His  His Gly Pro 
    1205                 1210                 1215             


Ser Asp  Glu Glu Gln Gly Ser  Pro Pro Glu Asp Lys  Leu Leu Arg 
    1220                 1225                 1230             


Ala Lys  Arg Asn Ser Tyr Thr  Asn Cys Leu Gln Lys  Ile Thr Cys 
    1235                 1240                 1245             


Pro His  Cys Pro Arg Val Phe  Pro Trp Ala Ser Ser  Leu Gln Arg 
    1250                 1255                 1260             


His Met  Leu Thr His Thr Asp  Ser Gln Ser Asp Ala  Glu Thr Ala 
    1265                 1270                 1275             


Ala Ala  Ala Gly Glu Val Leu  Asp Leu Thr Ser Arg  Asp Arg Glu 
    1280                 1285                 1290             


Gln Pro  Ser Glu Gly Ala Thr  Glu Leu Arg Gln Val  Ala Gly Asp 
    1295                 1300                 1305             


Ala Pro  Val Glu Gln Ala Thr  Ala Glu Thr Ala Ser  Pro Val His 
    1310                 1315                 1320             


Arg Glu  Glu His Gly Arg Gly  Glu Ser His Glu Pro  Glu Glu Glu 
    1325                 1330                 1335             


His Gly  Thr Glu Glu Ser Thr  Gly Asp Ala Asp Gly  Ala Glu Glu 
    1340                 1345                 1350             


Asp Ala  Ser Ser Asn Gln Ser  Leu Asp Leu Asp Phe  Ala Thr Lys 
    1355                 1360                 1365             


Leu Met  Asp Phe Lys Leu Ala  Glu Gly Asp Gly Glu  Ala Gly Ala 
    1370                 1375                 1380             


Gly Gly  Ala Ala Ser Gln Glu  Gln Lys Leu Ala Cys  Asp Thr Cys 
    1385                 1390                 1395             


Gly Lys  Ser Phe Lys Phe Leu  Gly Thr Leu Ser Arg  His Arg Lys 
    1400                 1405                 1410             


Ala His  Gly Arg Gln Glu Pro  Lys Asp Glu Lys Gly  Asp Gly Ala 
    1415                 1420                 1425             


Ser Thr  Ala Glu Glu Gly Pro  Gln Pro Ala Pro Glu  Gln Glu Glu 
    1430                 1435                 1440             


Lys Pro  Pro Glu Thr Pro Ala  Glu Val Val Glu Ser  Ala Pro Gly 
    1445                 1450                 1455             


Ala Gly  Glu Ala Pro Ala Glu  Lys Leu Ala Glu Glu  Thr Glu Gly 
    1460                 1465                 1470             


Pro Ser  Asp Gly Glu Ser Ala  Ala Glu Lys Arg Ser  Ser Glu Lys 
    1475                 1480                 1485             


Ser Asp  Asp Asp Lys Lys Pro  Lys Thr Asp Ser Pro  Lys Ser Val 
    1490                 1495                 1500             


Ala Ser  Lys Ala Asp Lys Arg  Lys Lys Val Cys Ser  Val Cys Asn 
    1505                 1510                 1515             


Lys Arg  Phe Trp Ser Leu Gln  Asp Leu Thr Arg His  Met Arg Ser 
    1520                 1525                 1530             


His Thr  Gly Glu Arg Pro Tyr  Lys Cys Gln Thr Cys  Glu Arg Thr 
    1535                 1540                 1545             


Phe Thr  Leu Lys His Ser Leu  Val Arg His Gln Arg  Ile His Gln 
    1550                 1555                 1560             


Lys Ala  Arg His Ala Lys His  His Gly Lys Asp Ser  Asp Lys Glu 
    1565                 1570                 1575             


Glu Arg  Gly Glu Glu Asp Ser  Glu Asn Glu Ser Thr  His Ser Gly 
    1580                 1585                 1590             


Asn Asn  Ala Val Ser Glu Asn  Glu Ala Glu Leu Ala  Pro Asn Ala 
    1595                 1600                 1605             


Ser Asn  His Met Ala Val Thr  Arg Ser Arg Lys Glu  Gly Leu Ala 
    1610                 1615                 1620             


Ser Ala  Thr Lys Asp Cys Ser  His Arg Glu Glu Lys  Val Thr Ala 
    1625                 1630                 1635             


Gly Trp  Pro Ser Glu Pro Gly  Gln Gly Asp Leu Asn  Pro Glu Ser 
    1640                 1645                 1650             


Pro Ala  Ala Leu Gly Gln Asp  Leu Leu Glu Pro Arg  Ser Lys Arg 
    1655                 1660                 1665             


Pro Ala  His Pro Ile Leu Ala  Thr Ala Asp Gly Ala  Ser Gln Leu 
    1670                 1675                 1680             


Val Gly  Met Glu 
    1685         


<210>  1222
<211>  7535
<212>  DNA
<213>  Homosapiens

<400>  1222
atgccaggga gccaagcgtc ctgcccggcc gttgctccga ctgtgtgttc caggagtggt     60

ggctctgagg tgtgaccctg cccacgtttg ggcccagcca ggttcagccc cccaataagg    120

agggcagctt gataacacaa agaaaacagt gtcaacgagt actaccaaga gaagaagaca    180

agaggtcaac acagactcat tttctactcc gtgtgaatga tagctacagc aggggaaagt    240

ttcatagtct atcagtgggt cagaaaatgg agttttatag cagaggcttc ttagaagctt    300

aaacccctgt cccaatgacg tcaagttcgc ccgctggctt ggaaggttca gacctatctt    360

ccatcaacac catgatgtcg gcggtcatga gtgtagggaa ggtcacagag aatggcggga    420

gcccccaggg gatcaagtcc ccctcgaagc ctccaggacc aaatcggatt ggcagaagga    480

accaggaaac gaaagaggag aagtcttcct ataactgccc cctgtgtgag aagatttgca    540

ctacccagca ccagctgacc atgcacattc gccagcacaa cacagacact ggaggagccg    600

accactcatg cagcatctgc ggaaagtcac tgagctcggc cagctccctc gatcgccaca    660

tgctggtgca ctctggcgag aggccttaca agtgcactgt gtgtggccag tcatttacca    720

ccaatgggaa catgcacaga catatgaaga tccatgagaa ggaccctaac agtgccacag    780

ccacagcccc tccatctcct ctgaaacgta ggcgattgtc ctccaagagg aaactgagtc    840

acgatgccga gtcagagaga gaagacccag caccagctaa aaagatggta gaagacgggc    900

agtcaggtga cttggagaag aaagctgatg aagtctttca ctgcccagta tgtttcaagg    960

agtttgtttg caagtatgga ctggagaccc acatggagac ccattcagat aacccactaa   1020

gatgtgacat ttgttgtgtc acctttcgaa cacatcgagg actgctgcgt cacaacgcgc   1080

ttgtccacaa acaacttccc agggatgcaa tgggcagacc tttcatacag aacaaccctt   1140

caattcctgc tggcttccac gacttaggat tcacggactt ctcctgtagg aagtttcctc   1200

gcatttctca ggcctggtgc gaaacaaacc tgcggaggtg catcagcgag caacaccgtt   1260

ttgtctgcga cacctgtgac aaggcgttcc ccatgctctg ctcactggct ctgcacaagc   1320

agacccatgt ggcggcagac cagggtcaag aaaagccgca ggccacgccc ctgcctggtg   1380

acgccctgga ccagaagggc ttcctggcct tgcttggcct gcagcacacc aaagacgtca   1440

ggcctgcccc cgccgaggag cccctgccgg atgacaacca ggcaattcag ctccagacac   1500

tcaagtgtca gctacctcag gaccccggct gcaccaacct gctgagcctg tcacctttcg   1560

aagctgcttc cctaggcggt tctctcacag ttctccccgc gaccaaggac agcataaagc   1620

acctgtccct gcagcccttc cagaagggct tcatcatcca gcctgacagc agcattgtgg   1680

tcaagcccat ctctggcgag tcggccatcg agctggcaga catccagcaa attctgaaga   1740

tggcagcctc ggctccccct cagatcagtc ttccgccctt ctccaaggcc cctgccgccc   1800

cactgcaggc gatcttcaag cacatgcccc ctctgaagcc aaagcccctg gtcacaccac   1860

ggacggtggt ggccacctcc acgcccccgc ctctcatcaa cgcccagcag gcttccccgg   1920

gctgtatcag ccccagcctg ccgccaccgc ccctgaagct cctcaaaggc tcagtggagg   1980

cggcctccaa cgcccacctg ctgcagtcca agtccgggac ccagccccac gcggccacgc   2040

ggctctccct gcagcagccg cgggcggagc tgccgggcca gcctgagatg aagacgcagc   2100

tggagcagga cagcatcatc gaggccctgc tgccgctgag catggaggcc aagatcaagc   2160

aggagatcac agagggggaa ctcaaggcct tcatgacagc gcccggcggc aagaagacgc   2220

ccgccatgcg caaggtgctc tacccctgcc gcttctgcaa ccaggtgttt gccttctcgg   2280

gggtcttgcg tgcccacgtg cgctcccacc tgggcatctc gccataccag tgcaacatct   2340

gcgactacat cgccgccgac aaggccgcgc tcatccgcca cctgcgcacg cacagtgggg   2400

agcggcccta catttgcaag atctgccact accccttcac tgtcaaagcc aactgcgagc   2460

ggcacctgcg caagaagcac ctcaaggcca cccgcaagga tatcgagaag aacatcgagt   2520

atgtgagtag cagcgcggcc gagctggtgg acgccttctg cgccccggac accgtgtgcc   2580

ggctgtgcgg cgaggacctc aagcactatc gtgccctgcg catccacatg cgcacgcact   2640

gcggccgcgg cctgggcggg ggccacaagg gccgcaagcc cttcgagtgc aaggagtgca   2700

gcgccgcgtt cgcggccaag cgcaactgca tccaccacat cctcaagcag cacctgcacg   2760

tgcccgagca ggacatcgag agctacgtgc tggccgccga cggcctgggc cccgcagagg   2820

cgccggccgc tgaggcgtcg gggcgcgggg aggacagtgg ctgcgctgcc cttggtgact   2880

gcaagcccct cactgccttc ctggaacccc agaacggctt tcttcacagg ggccccaccc   2940

agcctccacc tccccatgtc tcgatcaagt tggagcccgc cagtagcttt gcggtggact   3000

tcaatgagcc cctggacttc tcgcagaagg gcctggccct ggtccaagtg aagcaggaaa   3060

acatctcctt tctgagccct tcttccctgg tcccctatga ctgctccatg gagcccatcg   3120

acctgtccat ccccaagaac ttcaggaaag gggacaagga tttggccact cccagcgaag   3180

ccaagaagcc tgaggaggag gcggggagca gcgagcagcc ctctccctgc ccagcacccg   3240

gcccttctct tcctgtaact ttggggccca gcggaatcct ggaaagcccc atggcccctg   3300

ctccggcggc caccccggaa cccccagcac agcccctgca gggccctgtt cagctggcgg   3360

tcccaatcta ctcctcagcc ctggtcagca gccctccact cgtgggcagc tcagccctcc   3420

tgagtggcac agccttgctg cgtccactgc ggcccaagcc cccgctgctt ttgccaaagc   3480

cccccgtgac agaagagctg cccccgctgg cctccattgc ccagatcatc tcatctgtat   3540

cctcggcccc caccctgctg aaaaccaagg tggcggaccc agggcccgca agcactggca   3600

gtaacaccac ggcttcagac agcttaggag gttctgtccc caaagccgcc accaccgcca   3660

cccccgctgc caccaccagc ccaaaagagt ctagtgagcc tcccgctcca gccagcagcc   3720

cagaggctgc ctctcccacc gagcagggcc cagcgggcac gtcgaagaag aggggccgga   3780

aaagggggat gaggagccga ccccgcgcca acagcggcgg ggtggacctg gactccagcg   3840

gggagtttgc cagcatcgag aagatgctgg ccaccacaga caccaacaag ttcagtccgt   3900

ttctgcagac agcggaggac aacactcagg atgaggtggc cggagcccct gccgaccacc   3960

atgggcccag tgatgaagag cagggcagtc ccccagaaga caagctgctg agggccaagc   4020

ggaactcgta caccaactgc ctgcagaaga tcacctgtcc ccactgtccc cgggttttcc   4080

cttgggccag ctccctacag aggcacatgc tcacacacac tggtcagaaa cccttccctt   4140

gtcaaaaatg cgatgccttc ttttctacca aatctaactg tgaacgccac cagttgcgca   4200

aacacggagt taccacctgt tccctgagaa gaaacgggct tatcccccag tcaaaagaga   4260

gtgatgttgg atcccatgat agcacagaca gtcagtcgga tgcggagact gcagccgccg   4320

cgggcgaagt gctagacctc acctcacggg acagagagca gccgtcggag ggcgccactg   4380

agctccgcca ggtcgcaggg gatgcgcctg tggagcaggc cacggcggaa acggcctcgc   4440

cggtgcaccg ggaagagcac gggcgtgggg agagccatga gccggaggag gagcatggca   4500

ctgaggagag cactggggac gccgacggcg cggaagagga cgcgtcgagc aaccagagcc   4560

tggacctgga cttcgccacc aagctcatgg acttcaagct ggcggagggc gacggcgagg   4620

caggcgccgg gggcgcggcc tcgcaggagc agaagctcgc ctgcgacacc tgtgggaaga   4680

gcttcaagtt cctgggcacc ctgagccgcc accggaaggc gcacggccgc caggagccca   4740

aggacgagaa gggagatggc gccagcactg cagaggaggg gccccagccc gcccctgaac   4800

aggaggagaa gccccccgag accccggcag aggtggtgga gtcggccccg ggtgccgggg   4860

aggccccggc ggaaaagctc gcggaggaga cggagggccc ctccgacggg gagagcgcgg   4920

ccgagaaaag gtcctcagag aagagcgacg atgacaagaa accaaagaca gactccccca   4980

aaagcgtggc cagcaaggca gacaagagga agaaggtctg cagcgtgtgc aacaagcggt   5040

tctggtcgct gcaggacctg acccggcaca tgcgctccca cacaggggaa aggccataca   5100

aatgtcagac ctgcgagcga accttcacct tgaagcacag cctggttcgc caccagcgga   5160

tccaccagaa agccaggcat gccaaacacc acgggaagga cagcgacaag gaagagcggg   5220

gtgaggagga cagcgagaat gagtccaccc acagcggcaa caacgccgtc tcagagaacg   5280

aggctgagct ggctcccaat gccagcaacc acatggctgt cacccggagc cggaaggagg   5340

gcttggccag tgccaccaag gactgcagcc acagggagga gaaggtcacg gcagggtggc   5400

cgtctgagcc tggccagggt gaccttaacc cagagagccc ggcggccctg gggcaggacc   5460

tgctggagcc gcgcagcaag aggcctgccc acccaatcct ggccacagct gatggcgcct   5520

cccagctcgt ggggatggag tgacagcctc agtccccctc agcacagaca aaagccagca   5580

gagcaaagcg tctatacttc atggggtttc ctcagtgccc tttggctgtt gaggagtgag   5640

agagagagag agagagagag agagagagag agagagacaa gcaggagcgt ggctgctcgc   5700

tcagtgccat agccttaccg cagcctgcgc gggaggccac agcccgtgcc gattccagtg   5760

ccttaactac ttaccggatc cctccatatt atcatgggtg ttgtattttt ccaaaatgac   5820

ttcttaaaca aaacaaatat tataatgaat tgtctggaga ggacctcttc atttgagcat   5880

tagcgttatt ttgtattggt gtgtgtgagc ttgttcttgt gaatctgtga tagcaccgtt   5940

tgttctgtga gctggaaaca gaaggaaaaa acataccctt gggtacccat agccaataac   6000

tggaagaaaa tgatgtgaat ttcatgtaaa tgaccagagg aaagatggat aagatgataa   6060

tttcttaaat agacattttc cttttttctt tgtgcttcat ggtggagctg tcatctggtc   6120

cttggtatta caggatgtgg ttgatgaagg tttccaatat ggtttcaggc caaaaccagg   6180

gaagattcta gcttcagcct catgtccatt tccagtctgt cagcattaga catggtcact   6240

gttcaagttt caagacatcc attcttaact atagagaaga gttactcccc tggcgtctta   6300

acctatggaa aacatgcacg gataggatat atttgattgc ctcctcttcc ctttcagtat   6360

atgtattatt aatattatta ttattattat tattattagt tcatcagttt gctgttctct   6420

gcagtgagca gaatcaaatg ggcaatattt gtcctgggag acctgtgccg cacccaggtc   6480

cccgtgttaa cgtgtgcctg cggttgtggt tggcaccctc gggtggtagc tcttctactg   6540

taatgagaca agcctttctt ctgtcactgc agaatttaga aggggccgtg agcagtcttc   6600

ccaagcatgg tccaggagca gctcagagag ggtggagtga ggatgcatgc atccagggaa   6660

caggcatcaa gaagccaggg ccgtgcctgg agcactgcag agatgacttt ggagaaagca   6720

aagcagtgac ccagtgacca ggcacattac tcgtgagcga ggtattccca gtcttcctgc   6780

taagcctaat ccaagcctta cccagctgtg ctactgtcat ttgcaaagca aggaaatact   6840

actactggta ataaaactac actagcaaga tgtcagataa gaaataggtt tatatttacc   6900

ttcctgcgat gtggggttgg tgcttgaaga taaatgtgct gtttctagtt tcttaaatag   6960

cccacacccc tggatgcaaa aaggcagggt tatttttacc catgagcatc ctgtgcaggc   7020

aatagacttc cctcactgtc tccgcctgca gggaggagaa tgtaccccac tgcacctgag   7080

ctcctggtcc ctcagccaag acctcagggg tccccagcca gcctgctgct ggggacccct   7140

gtgcttgctg cagtgtatgg agcctcttgc cttcccctgg ggaggcaccc ctgtacccca   7200

gcttccttcc cctggccttt tctggcccca gtgctcctcc tttacataga cttgttcaca   7260

cagaaacgtg cacgccccct tttctccgcc acttcaccag tttctgaaat ccaacctccc   7320

agacttcaca ggaagataga tattcttgag ataatgaaaa gtgatatctt cgcatacgaa   7380

aggaaaaaag gttgaggtat atatgatttt taactgtatt aggggtgtat gaaccagttt   7440

aaaaacgagg ttttatttac tgtagagatg aatgcaaatc agaaccaatg atcccttggc   7500

ctacttagtt aaaaccagtt catacatccc ttagg                              7535


<210>  1223
<211>  1742
<212>  PRT
<213>  Homosapiens

<400>  1223

Met Thr Ser Ser Ser Pro Ala Gly Leu Glu Gly Ser Asp Leu Ser Ser 
1               5                   10                  15      


Ile Asn Thr Met Met Ser Ala Val Met Ser Val Gly Lys Val Thr Glu 
            20                  25                  30          


Asn Gly Gly Ser Pro Gln Gly Ile Lys Ser Pro Ser Lys Pro Pro Gly 
        35                  40                  45              


Pro Asn Arg Ile Gly Arg Arg Asn Gln Glu Thr Lys Glu Glu Lys Ser 
    50                  55                  60                  


Ser Tyr Asn Cys Pro Leu Cys Glu Lys Ile Cys Thr Thr Gln His Gln 
65                  70                  75                  80  


Leu Thr Met His Ile Arg Gln His Asn Thr Asp Thr Gly Gly Ala Asp 
                85                  90                  95      


His Ser Cys Ser Ile Cys Gly Lys Ser Leu Ser Ser Ala Ser Ser Leu 
            100                 105                 110         


Asp Arg His Met Leu Val His Ser Gly Glu Arg Pro Tyr Lys Cys Thr 
        115                 120                 125             


Val Cys Gly Gln Ser Phe Thr Thr Asn Gly Asn Met His Arg His Met 
    130                 135                 140                 


Lys Ile His Glu Lys Asp Pro Asn Ser Ala Thr Ala Thr Ala Pro Pro 
145                 150                 155                 160 


Ser Pro Leu Lys Arg Arg Arg Leu Ser Ser Lys Arg Lys Leu Ser His 
                165                 170                 175     


Asp Ala Glu Ser Glu Arg Glu Asp Pro Ala Pro Ala Lys Lys Met Val 
            180                 185                 190         


Glu Asp Gly Gln Ser Gly Asp Leu Glu Lys Lys Ala Asp Glu Val Phe 
        195                 200                 205             


His Cys Pro Val Cys Phe Lys Glu Phe Val Cys Lys Tyr Gly Leu Glu 
    210                 215                 220                 


Thr His Met Glu Thr His Ser Asp Asn Pro Leu Arg Cys Asp Ile Cys 
225                 230                 235                 240 


Cys Val Thr Phe Arg Thr His Arg Gly Leu Leu Arg His Asn Ala Leu 
                245                 250                 255     


Val His Lys Gln Leu Pro Arg Asp Ala Met Gly Arg Pro Phe Ile Gln 
            260                 265                 270         


Asn Asn Pro Ser Ile Pro Ala Gly Phe His Asp Leu Gly Phe Thr Asp 
        275                 280                 285             


Phe Ser Cys Arg Lys Phe Pro Arg Ile Ser Gln Ala Trp Cys Glu Thr 
    290                 295                 300                 


Asn Leu Arg Arg Cys Ile Ser Glu Gln His Arg Phe Val Cys Asp Thr 
305                 310                 315                 320 


Cys Asp Lys Ala Phe Pro Met Leu Cys Ser Leu Ala Leu His Lys Gln 
                325                 330                 335     


Thr His Val Ala Ala Asp Gln Gly Gln Glu Lys Pro Gln Ala Thr Pro 
            340                 345                 350         


Leu Pro Gly Asp Ala Leu Asp Gln Lys Gly Phe Leu Ala Leu Leu Gly 
        355                 360                 365             


Leu Gln His Thr Lys Asp Val Arg Pro Ala Pro Ala Glu Glu Pro Leu 
    370                 375                 380                 


Pro Asp Asp Asn Gln Ala Ile Gln Leu Gln Thr Leu Lys Cys Gln Leu 
385                 390                 395                 400 


Pro Gln Asp Pro Gly Cys Thr Asn Leu Leu Ser Leu Ser Pro Phe Glu 
                405                 410                 415     


Ala Ala Ser Leu Gly Gly Ser Leu Thr Val Leu Pro Ala Thr Lys Asp 
            420                 425                 430         


Ser Ile Lys His Leu Ser Leu Gln Pro Phe Gln Lys Gly Phe Ile Ile 
        435                 440                 445             


Gln Pro Asp Ser Ser Ile Val Val Lys Pro Ile Ser Gly Glu Ser Ala 
    450                 455                 460                 


Ile Glu Leu Ala Asp Ile Gln Gln Ile Leu Lys Met Ala Ala Ser Ala 
465                 470                 475                 480 


Pro Pro Gln Ile Ser Leu Pro Pro Phe Ser Lys Ala Pro Ala Ala Pro 
                485                 490                 495     


Leu Gln Ala Ile Phe Lys His Met Pro Pro Leu Lys Pro Lys Pro Leu 
            500                 505                 510         


Val Thr Pro Arg Thr Val Val Ala Thr Ser Thr Pro Pro Pro Leu Ile 
        515                 520                 525             


Asn Ala Gln Gln Ala Ser Pro Gly Cys Ile Ser Pro Ser Leu Pro Pro 
    530                 535                 540                 


Pro Pro Leu Lys Leu Leu Lys Gly Ser Val Glu Ala Ala Ser Asn Ala 
545                 550                 555                 560 


His Leu Leu Gln Ser Lys Ser Gly Thr Gln Pro His Ala Ala Thr Arg 
                565                 570                 575     


Leu Ser Leu Gln Gln Pro Arg Ala Glu Leu Pro Gly Gln Pro Glu Met 
            580                 585                 590         


Lys Thr Gln Leu Glu Gln Asp Ser Ile Ile Glu Ala Leu Leu Pro Leu 
        595                 600                 605             


Ser Met Glu Ala Lys Ile Lys Gln Glu Ile Thr Glu Gly Glu Leu Lys 
    610                 615                 620                 


Ala Phe Met Thr Ala Pro Gly Gly Lys Lys Thr Pro Ala Met Arg Lys 
625                 630                 635                 640 


Val Leu Tyr Pro Cys Arg Phe Cys Asn Gln Val Phe Ala Phe Ser Gly 
                645                 650                 655     


Val Leu Arg Ala His Val Arg Ser His Leu Gly Ile Ser Pro Tyr Gln 
            660                 665                 670         


Cys Asn Ile Cys Asp Tyr Ile Ala Ala Asp Lys Ala Ala Leu Ile Arg 
        675                 680                 685             


His Leu Arg Thr His Ser Gly Glu Arg Pro Tyr Ile Cys Lys Ile Cys 
    690                 695                 700                 


His Tyr Pro Phe Thr Val Lys Ala Asn Cys Glu Arg His Leu Arg Lys 
705                 710                 715                 720 


Lys His Leu Lys Ala Thr Arg Lys Asp Ile Glu Lys Asn Ile Glu Tyr 
                725                 730                 735     


Val Ser Ser Ser Ala Ala Glu Leu Val Asp Ala Phe Cys Ala Pro Asp 
            740                 745                 750         


Thr Val Cys Arg Leu Cys Gly Glu Asp Leu Lys His Tyr Arg Ala Leu 
        755                 760                 765             


Arg Ile His Met Arg Thr His Cys Gly Arg Gly Leu Gly Gly Gly His 
    770                 775                 780                 


Lys Gly Arg Lys Pro Phe Glu Cys Lys Glu Cys Ser Ala Ala Phe Ala 
785                 790                 795                 800 


Ala Lys Arg Asn Cys Ile His His Ile Leu Lys Gln His Leu His Val 
                805                 810                 815     


Pro Glu Gln Asp Ile Glu Ser Tyr Val Leu Ala Ala Asp Gly Leu Gly 
            820                 825                 830         


Pro Ala Glu Ala Pro Ala Ala Glu Ala Ser Gly Arg Gly Glu Asp Ser 
        835                 840                 845             


Gly Cys Ala Ala Leu Gly Asp Cys Lys Pro Leu Thr Ala Phe Leu Glu 
    850                 855                 860                 


Pro Gln Asn Gly Phe Leu His Arg Gly Pro Thr Gln Pro Pro Pro Pro 
865                 870                 875                 880 


His Val Ser Ile Lys Leu Glu Pro Ala Ser Ser Phe Ala Val Asp Phe 
                885                 890                 895     


Asn Glu Pro Leu Asp Phe Ser Gln Lys Gly Leu Ala Leu Val Gln Val 
            900                 905                 910         


Lys Gln Glu Asn Ile Ser Phe Leu Ser Pro Ser Ser Leu Val Pro Tyr 
        915                 920                 925             


Asp Cys Ser Met Glu Pro Ile Asp Leu Ser Ile Pro Lys Asn Phe Arg 
    930                 935                 940                 


Lys Gly Asp Lys Asp Leu Ala Thr Pro Ser Glu Ala Lys Lys Pro Glu 
945                 950                 955                 960 


Glu Glu Ala Gly Ser Ser Glu Gln Pro Ser Pro Cys Pro Ala Pro Gly 
                965                 970                 975     


Pro Ser Leu Pro Val Thr Leu Gly Pro Ser Gly Ile Leu Glu Ser Pro 
            980                 985                 990         


Met Ala Pro Ala Pro Ala Ala Thr  Pro Glu Pro Pro Ala  Gln Pro Leu 
        995                 1000                 1005             


Gln Gly  Pro Val Gln Leu Ala  Val Pro Ile Tyr Ser  Ser Ala Leu 
    1010                 1015                 1020             


Val Ser  Ser Pro Pro Leu Val  Gly Ser Ser Ala Leu  Leu Ser Gly 
    1025                 1030                 1035             


Thr Ala  Leu Leu Arg Pro Leu  Arg Pro Lys Pro Pro  Leu Leu Leu 
    1040                 1045                 1050             


Pro Lys  Pro Pro Val Thr Glu  Glu Leu Pro Pro Leu  Ala Ser Ile 
    1055                 1060                 1065             


Ala Gln  Ile Ile Ser Ser Val  Ser Ser Ala Pro Thr  Leu Leu Lys 
    1070                 1075                 1080             


Thr Lys  Val Ala Asp Pro Gly  Pro Ala Ser Thr Gly  Ser Asn Thr 
    1085                 1090                 1095             


Thr Ala  Ser Asp Ser Leu Gly  Gly Ser Val Pro Lys  Ala Ala Thr 
    1100                 1105                 1110             


Thr Ala  Thr Pro Ala Ala Thr  Thr Ser Pro Lys Glu  Ser Ser Glu 
    1115                 1120                 1125             


Pro Pro  Ala Pro Ala Ser Ser  Pro Glu Ala Ala Ser  Pro Thr Glu 
    1130                 1135                 1140             


Gln Gly  Pro Ala Gly Thr Ser  Lys Lys Arg Gly Arg  Lys Arg Gly 
    1145                 1150                 1155             


Met Arg  Ser Arg Pro Arg Ala  Asn Ser Gly Gly Val  Asp Leu Asp 
    1160                 1165                 1170             


Ser Ser  Gly Glu Phe Ala Ser  Ile Glu Lys Met Leu  Ala Thr Thr 
    1175                 1180                 1185             


Asp Thr  Asn Lys Phe Ser Pro  Phe Leu Gln Thr Ala  Glu Asp Asn 
    1190                 1195                 1200             


Thr Gln  Asp Glu Val Ala Gly  Ala Pro Ala Asp His  His Gly Pro 
    1205                 1210                 1215             


Ser Asp  Glu Glu Gln Gly Ser  Pro Pro Glu Asp Lys  Leu Leu Arg 
    1220                 1225                 1230             


Ala Lys  Arg Asn Ser Tyr Thr  Asn Cys Leu Gln Lys  Ile Thr Cys 
    1235                 1240                 1245             


Pro His  Cys Pro Arg Val Phe  Pro Trp Ala Ser Ser  Leu Gln Arg 
    1250                 1255                 1260             


His Met  Leu Thr His Thr Gly  Gln Lys Pro Phe Pro  Cys Gln Lys 
    1265                 1270                 1275             


Cys Asp  Ala Phe Phe Ser Thr  Lys Ser Asn Cys Glu  Arg His Gln 
    1280                 1285                 1290             


Leu Arg  Lys His Gly Val Thr  Thr Cys Ser Leu Arg  Arg Asn Gly 
    1295                 1300                 1305             


Leu Ile  Pro Gln Ser Lys Glu  Ser Asp Val Gly Ser  His Asp Ser 
    1310                 1315                 1320             


Thr Asp  Ser Gln Ser Asp Ala  Glu Thr Ala Ala Ala  Ala Gly Glu 
    1325                 1330                 1335             


Val Leu  Asp Leu Thr Ser Arg  Asp Arg Glu Gln Pro  Ser Glu Gly 
    1340                 1345                 1350             


Ala Thr  Glu Leu Arg Gln Val  Ala Gly Asp Ala Pro  Val Glu Gln 
    1355                 1360                 1365             


Ala Thr  Ala Glu Thr Ala Ser  Pro Val His Arg Glu  Glu His Gly 
    1370                 1375                 1380             


Arg Gly  Glu Ser His Glu Pro  Glu Glu Glu His Gly  Thr Glu Glu 
    1385                 1390                 1395             


Ser Thr  Gly Asp Ala Asp Gly  Ala Glu Glu Asp Ala  Ser Ser Asn 
    1400                 1405                 1410             


Gln Ser  Leu Asp Leu Asp Phe  Ala Thr Lys Leu Met  Asp Phe Lys 
    1415                 1420                 1425             


Leu Ala  Glu Gly Asp Gly Glu  Ala Gly Ala Gly Gly  Ala Ala Ser 
    1430                 1435                 1440             


Gln Glu  Gln Lys Leu Ala Cys  Asp Thr Cys Gly Lys  Ser Phe Lys 
    1445                 1450                 1455             


Phe Leu  Gly Thr Leu Ser Arg  His Arg Lys Ala His  Gly Arg Gln 
    1460                 1465                 1470             


Glu Pro  Lys Asp Glu Lys Gly  Asp Gly Ala Ser Thr  Ala Glu Glu 
    1475                 1480                 1485             


Gly Pro  Gln Pro Ala Pro Glu  Gln Glu Glu Lys Pro  Pro Glu Thr 
    1490                 1495                 1500             


Pro Ala  Glu Val Val Glu Ser  Ala Pro Gly Ala Gly  Glu Ala Pro 
    1505                 1510                 1515             


Ala Glu  Lys Leu Ala Glu Glu  Thr Glu Gly Pro Ser  Asp Gly Glu 
    1520                 1525                 1530             


Ser Ala  Ala Glu Lys Arg Ser  Ser Glu Lys Ser Asp  Asp Asp Lys 
    1535                 1540                 1545             


Lys Pro  Lys Thr Asp Ser Pro  Lys Ser Val Ala Ser  Lys Ala Asp 
    1550                 1555                 1560             


Lys Arg  Lys Lys Val Cys Ser  Val Cys Asn Lys Arg  Phe Trp Ser 
    1565                 1570                 1575             


Leu Gln  Asp Leu Thr Arg His  Met Arg Ser His Thr  Gly Glu Arg 
    1580                 1585                 1590             


Pro Tyr  Lys Cys Gln Thr Cys  Glu Arg Thr Phe Thr  Leu Lys His 
    1595                 1600                 1605             


Ser Leu  Val Arg His Gln Arg  Ile His Gln Lys Ala  Arg His Ala 
    1610                 1615                 1620             


Lys His  His Gly Lys Asp Ser  Asp Lys Glu Glu Arg  Gly Glu Glu 
    1625                 1630                 1635             


Asp Ser  Glu Asn Glu Ser Thr  His Ser Gly Asn Asn  Ala Val Ser 
    1640                 1645                 1650             


Glu Asn  Glu Ala Glu Leu Ala  Pro Asn Ala Ser Asn  His Met Ala 
    1655                 1660                 1665             


Val Thr  Arg Ser Arg Lys Glu  Gly Leu Ala Ser Ala  Thr Lys Asp 
    1670                 1675                 1680             


Cys Ser  His Arg Glu Glu Lys  Val Thr Ala Gly Trp  Pro Ser Glu 
    1685                 1690                 1695             


Pro Gly  Gln Gly Asp Leu Asn  Pro Glu Ser Pro Ala  Ala Leu Gly 
    1700                 1705                 1710             


Gln Asp  Leu Leu Glu Pro Arg  Ser Lys Arg Pro Ala  His Pro Ile 
    1715                 1720                 1725             


Leu Ala  Thr Ala Asp Gly Ala  Ser Gln Leu Val Gly  Met Glu 
    1730                 1735                 1740         


<210>  1224
<211>  7555
<212>  DNA
<213>  Homosapiens

<400>  1224
ttcagacacc tgagagcatc ctgttctggg tacagtgtgt gtatgtatat gtttgtttga     60

agccgctggt cctcgccttt tactccttag ctggacagcg ggttcgggat ctgccccatg    120

actaaggctg aagtggaaag ttgcgaagat agaacaagag ttgttcctta gggtggtgtc    180

cctaaacttg aaagtggact tggtcctgct cgcaggttgc tccgactgtg tgttccagga    240

gtggtggctc tgaggtgtga ccctgcccac gtttgggccc agccaggttc agccccccaa    300

taaggagggc agcttgataa cacaaagaaa acagtgtcaa cgagtactac caagagaaga    360

agacaagagg tcaacacaga ctcattttct actccgtgtg aatgatagct acagcagggg    420

aaagtttcat agtctatcag tgggtcagaa aatggagttt tatagcagag gcttcttaga    480

agcttaaacc cctgtcccaa tgacgtcaag ttcgcccgct ggcttggaag gttcagacct    540

atcttccatc aacaccatga tgtcggcggt catgagtgta gggaaggtca cagagaatgg    600

cgggagcccc caggggatca agtccccctc gaagcctcca ggaccaaatc ggattggcag    660

aaggaaccag gaaacgaaag aggagaagtc ttcctataac tgccccctgt gtgagaagat    720

ttgcactacc cagcaccagc tgaccatgca cattcgccag cacaacacag acactggagg    780

agccgaccac tcatgcagca tctgcggaaa gtcactgagc tcggccagct ccctcgatcg    840

ccacatgctg gtgcactctg gcgagaggcc ttacaagtgc actgtgtgtg gccagtcatt    900

taccaccaat gggaacatgc acagacatat gaagatccat gagaaggacc ctaacagtgc    960

cacagccaca gcccctccat ctcctctgaa acgtaggcga ttgtcctcca agaggaaact   1020

gagtcacgat gccgagtcag agagagaaga cccagcacca gctaaaaaga tggtagaaga   1080

cgggcagtca ggtgacttgg agaagaaagc tgatgaagtc tttcactgcc cagtatgttt   1140

caaggagttt gtttgcaagt atggactgga gacccacatg gagacccatt cagataaccc   1200

actaagatgt gacatttgtt gtgtcacctt tcgaacacat cgaggactgc tgcgtcacaa   1260

cgcgcttgtc cacaaacaac ttcccaggga tgcaatgggc agacctttca tacagaacaa   1320

cccttcaatt cctgctggct tccacgactt aggattcacg gacttctcct gtaggaagtt   1380

tcctcgcatt tctcaggcct ggtgcgaaac aaacctgcgg aggtgcatca gcgagcaaca   1440

ccgttttgtc tgcgacacct gtgacaaggc gttccccatg ctctgctcac tggctctgca   1500

caagcagacc catgtggcgg cagaccaggg tcaagaaaag ccgcaggcca cgcccctgcc   1560

tggtgacgcc ctggaccaga agggcttcct ggccttgctt ggcctgcagc acaccaaaga   1620

cgtcaggcct gcccccgccg aggagcccct gccggatgac aaccaggcaa ttcagctcca   1680

gacactcaag tgtcagctac ctcaggaccc cggctgcacc aacctgctga gcctgtcacc   1740

tttcgaagct gcttccctag gcggttctct cacagttctc cccgcgacca aggacagcat   1800

aaagcacctg tccctgcagc ccttccagaa gggcttcatc atccagcctg acagcagcat   1860

tgtggtcaag cccatctctg gcgagtcggc catcgagctg gcagacatcc agcaaattct   1920

gaagatggca gcctcggctc cccctcagat cagtcttccg cccttctcca aggcccctgc   1980

cgccccactg caggcgatct tcaagcacat gccccctctg aagccaaagc ccctggtcac   2040

accacggacg gtggtggcca cctccacgcc cccgcctctc atcaacgccc agcaggcttc   2100

cccgggctgt atcagcccca gcctgccgcc accgcccctg aagctcctca aaggctcagt   2160

ggaggcggcc tccaacgccc acctgctgca gtccaagtcc gggacccagc cccacgcggc   2220

cacgcggctc tccctgcagc agccgcgggc ggagctgccg ggccagcctg agatgaagac   2280

gcagctggag caggacagca tcatcgaggc cctgctgccg ctgagcatgg aggccaagat   2340

caagcaggag atcacagagg gggaactcaa ggccttcatg acagcgcccg gcggcaagaa   2400

gacgcccgcc atgcgcaagg tgctctaccc ctgccgcttc tgcaaccagg tgtttgcctt   2460

ctcgggggtc ttgcgtgccc acgtgcgctc ccacctgggc atctcgccat accagtgcaa   2520

catctgcgac tacatcgccg ccgacaaggc cgcgctcatc cgccacctgc gcacgcacag   2580

tggggagcgg ccctacattt gcaagatctg ccactacccc ttcactgtca aagccaactg   2640

cgagcggcac ctgcgcaaga agcacctcaa ggccacccgc aaggatatcg agaagaacat   2700

cgagtatgtg agtagcagcg cggccgagct ggtggacgcc ttctgcgccc cggacaccgt   2760

gtgccggctg tgcggcgagg acctcaagca ctatcgtgcc ctgcgcatcc acatgcgcac   2820

gcactgcggc cgcggcctgg gcgggggcca caagggccgc aagcccttcg agtgcaagga   2880

gtgcagcgcc gcgttcgcgg ccaagcgcaa ctgcatccac cacatcctca agcagcacct   2940

gcacgtgccc gagcaggaca tcgagagcta cgtgctggcc gccgacggcc tgggccccgc   3000

agaggcgccg gccgctgagg cgtcggggcg cggggaggac agtggctgcg ctgcccttgg   3060

tgactgcaag cccctcactg ccttcctgga accccagaac ggctttcttc acaggggccc   3120

cacccagcct ccacctcccc atgtctcgat caagttggag cccgccagta gctttgcggt   3180

ggacttcaat gagcccctgg acttctcgca gaagggcctg gccctggtcc aagtgaagca   3240

ggaaaacatc tcctttctga gcccttcttc cctggtcccc tatgactgct ccatggagcc   3300

catcgacctg tccatcccca agaacttcag gaaaggggac aaggatttgg ccactcccag   3360

cgaagccaag aagcctgagg aggaggcggg gagcagcgag cagccctctc cctgcccagc   3420

acccggccct tctcttcctg taactttggg gcccagcgga atcctggaaa gccccatggc   3480

ccctgctccg gcggccaccc cggaaccccc agcacagccc ctgcagggcc ctgttcagct   3540

ggcggtccca atctactcct cagccctggt cagcagccct ccactcgtgg gcagctcagc   3600

cctcctgagt ggcacagcct tgctgcgtcc actgcggccc aagcccccgc tgcttttgcc   3660

aaagcccccc gtgacagaag agctgccccc gctggcctcc attgcccaga tcatctcatc   3720

tgtatcctcg gcccccaccc tgctgaaaac caaggtggcg gacccagggc ccgcaagcac   3780

tggcagtaac accacggctt cagacagctt aggaggttct gtccccaaag ccgccaccac   3840

cgccaccccc gctgccacca ccagcccaaa agagtctagt gagcctcccg ctccagccag   3900

cagcccagag gctgcctctc ccaccgagca gggcccagcg ggcacgtcga agaagagggg   3960

ccggaaaagg gggatgagga gccgaccccg cgccaacagc ggcggggtgg acctggactc   4020

cagcggggag tttgccagca tcgagaagat gctggccacc acagacacca acaagttcag   4080

tccgtttctg cagacagcgg aggacaacac tcaggatgag gtggccggag cccctgccga   4140

ccaccatggg cccagtgatg aagagcaggg cagtccccca gaagacaagc tgctgagggc   4200

caagcggaac tcgtacacca actgcctgca gaagatcacc tgtccccact gtccccgggt   4260

tttcccttgg gccagctccc tacagaggca catgctcaca cacactgaca gtcagtcgga   4320

tgcggagact gcagccgccg cgggcgaagt gctagacctc acctcacggg acagagagca   4380

gccgtcggag ggcgccactg agctccgcca ggtcgcaggg gatgcgcctg tggagcaggc   4440

cacggcggaa acggcctcgc cggtgcaccg ggaagagcac gggcgtgggg agagccatga   4500

gccggaggag gagcatggca ctgaggagag cactggggac gccgacggcg cggaagagga   4560

cgcgtcgagc aaccagagcc tggacctgga cttcgccacc aagctcatgg acttcaagct   4620

ggcggagggc gacggcgagg caggcgccgg gggcgcggcc tcgcaggagc agaagctcgc   4680

ctgcgacacc tgtgggaaga gcttcaagtt cctgggcacc ctgagccgcc accggaaggc   4740

gcacggccgc caggagccca aggacgagaa gggagatggc gccagcactg cagaggaggg   4800

gccccagccc gcccctgaac aggaggagaa gccccccgag accccggcag aggtggtgga   4860

gtcggccccg ggtgccgggg aggccccggc ggaaaagctc gcggaggaga cggagggccc   4920

ctccgacggg gagagcgcgg ccgagaaaag gtcctcagag aagagcgacg atgacaagaa   4980

accaaagaca gactccccca aaagcgtggc cagcaaggca gacaagagga agaaggtctg   5040

cagcgtgtgc aacaagcggt tctggtcgct gcaggacctg acccggcaca tgcgctccca   5100

cacaggggaa aggccataca aatgtcagac ctgcgagcga accttcacct tgaagcacag   5160

cctggttcgc caccagcgga tccaccagaa agccaggcat gccaaacacc acgggaagga   5220

cagcgacaag gaagagcggg gtgaggagga cagcgagaat gagtccaccc acagcggcaa   5280

caacgccgtc tcagagaacg aggctgagct ggctcccaat gccagcaacc acatggctgt   5340

cacccggagc cggaaggagg gcttggccag tgccaccaag gactgcagcc acagggagga   5400

gaaggtcacg gcagggtggc cgtctgagcc tggccagggt gaccttaacc cagagagccc   5460

ggcggccctg gggcaggacc tgctggagcc gcgcagcaag aggcctgccc acccaatcct   5520

ggccacagct gatggcgcct cccagctcgt ggggatggag tgacagcctc agtccccctc   5580

agcacagaca aaagccagca gagcaaagcg tctatacttc atggggtttc ctcagtgccc   5640

tttggctgtt gaggagtgag agagagagag agagagagag agagagagag agagagacaa   5700

gcaggagcgt ggctgctcgc tcagtgccat agccttaccg cagcctgcgc gggaggccac   5760

agcccgtgcc gattccagtg ccttaactac ttaccggatc cctccatatt atcatgggtg   5820

ttgtattttt ccaaaatgac ttcttaaaca aaacaaatat tataatgaat tgtctggaga   5880

ggacctcttc atttgagcat tagcgttatt ttgtattggt gtgtgtgagc ttgttcttgt   5940

gaatctgtga tagcaccgtt tgttctgtga gctggaaaca gaaggaaaaa acataccctt   6000

gggtacccat agccaataac tggaagaaaa tgatgtgaat ttcatgtaaa tgaccagagg   6060

aaagatggat aagatgataa tttcttaaat agacattttc cttttttctt tgtgcttcat   6120

ggtggagctg tcatctggtc cttggtatta caggatgtgg ttgatgaagg tttccaatat   6180

ggtttcaggc caaaaccagg gaagattcta gcttcagcct catgtccatt tccagtctgt   6240

cagcattaga catggtcact gttcaagttt caagacatcc attcttaact atagagaaga   6300

gttactcccc tggcgtctta acctatggaa aacatgcacg gataggatat atttgattgc   6360

ctcctcttcc ctttcagtat atgtattatt aatattatta ttattattat tattattagt   6420

tcatcagttt gctgttctct gcagtgagca gaatcaaatg ggcaatattt gtcctgggag   6480

acctgtgccg cacccaggtc cccgtgttaa cgtgtgcctg cggttgtggt tggcaccctc   6540

gggtggtagc tcttctactg taatgagaca agcctttctt ctgtcactgc agaatttaga   6600

aggggccgtg agcagtcttc ccaagcatgg tccaggagca gctcagagag ggtggagtga   6660

ggatgcatgc atccagggaa caggcatcaa gaagccaggg ccgtgcctgg agcactgcag   6720

agatgacttt ggagaaagca aagcagtgac ccagtgacca ggcacattac tcgtgagcga   6780

ggtattccca gtcttcctgc taagcctaat ccaagcctta cccagctgtg ctactgtcat   6840

ttgcaaagca aggaaatact actactggta ataaaactac actagcaaga tgtcagataa   6900

gaaataggtt tatatttacc ttcctgcgat gtggggttgg tgcttgaaga taaatgtgct   6960

gtttctagtt tcttaaatag cccacacccc tggatgcaaa aaggcagggt tatttttacc   7020

catgagcatc ctgtgcaggc aatagacttc cctcactgtc tccgcctgca gggaggagaa   7080

tgtaccccac tgcacctgag ctcctggtcc ctcagccaag acctcagggg tccccagcca   7140

gcctgctgct ggggacccct gtgcttgctg cagtgtatgg agcctcttgc cttcccctgg   7200

ggaggcaccc ctgtacccca gcttccttcc cctggccttt tctggcccca gtgctcctcc   7260

tttacataga cttgttcaca cagaaacgtg cacgccccct tttctccgcc acttcaccag   7320

tttctgaaat ccaacctccc agacttcaca ggaagataga tattcttgag ataatgaaaa   7380

gtgatatctt cgcatacgaa aggaaaaaag gttgaggtat atatgatttt taactgtatt   7440

aggggtgtat gaaccagttt aaaaacgagg ttttatttac tgtagagatg aatgcaaatc   7500

agaaccaatg atcccttggc ctacttagtt aaaaccagtt catacatccc ttagg        7555


<210>  1225
<211>  1687
<212>  PRT
<213>  Homosapiens

<400>  1225

Met Thr Ser Ser Ser Pro Ala Gly Leu Glu Gly Ser Asp Leu Ser Ser 
1               5                   10                  15      


Ile Asn Thr Met Met Ser Ala Val Met Ser Val Gly Lys Val Thr Glu 
            20                  25                  30          


Asn Gly Gly Ser Pro Gln Gly Ile Lys Ser Pro Ser Lys Pro Pro Gly 
        35                  40                  45              


Pro Asn Arg Ile Gly Arg Arg Asn Gln Glu Thr Lys Glu Glu Lys Ser 
    50                  55                  60                  


Ser Tyr Asn Cys Pro Leu Cys Glu Lys Ile Cys Thr Thr Gln His Gln 
65                  70                  75                  80  


Leu Thr Met His Ile Arg Gln His Asn Thr Asp Thr Gly Gly Ala Asp 
                85                  90                  95      


His Ser Cys Ser Ile Cys Gly Lys Ser Leu Ser Ser Ala Ser Ser Leu 
            100                 105                 110         


Asp Arg His Met Leu Val His Ser Gly Glu Arg Pro Tyr Lys Cys Thr 
        115                 120                 125             


Val Cys Gly Gln Ser Phe Thr Thr Asn Gly Asn Met His Arg His Met 
    130                 135                 140                 


Lys Ile His Glu Lys Asp Pro Asn Ser Ala Thr Ala Thr Ala Pro Pro 
145                 150                 155                 160 


Ser Pro Leu Lys Arg Arg Arg Leu Ser Ser Lys Arg Lys Leu Ser His 
                165                 170                 175     


Asp Ala Glu Ser Glu Arg Glu Asp Pro Ala Pro Ala Lys Lys Met Val 
            180                 185                 190         


Glu Asp Gly Gln Ser Gly Asp Leu Glu Lys Lys Ala Asp Glu Val Phe 
        195                 200                 205             


His Cys Pro Val Cys Phe Lys Glu Phe Val Cys Lys Tyr Gly Leu Glu 
    210                 215                 220                 


Thr His Met Glu Thr His Ser Asp Asn Pro Leu Arg Cys Asp Ile Cys 
225                 230                 235                 240 


Cys Val Thr Phe Arg Thr His Arg Gly Leu Leu Arg His Asn Ala Leu 
                245                 250                 255     


Val His Lys Gln Leu Pro Arg Asp Ala Met Gly Arg Pro Phe Ile Gln 
            260                 265                 270         


Asn Asn Pro Ser Ile Pro Ala Gly Phe His Asp Leu Gly Phe Thr Asp 
        275                 280                 285             


Phe Ser Cys Arg Lys Phe Pro Arg Ile Ser Gln Ala Trp Cys Glu Thr 
    290                 295                 300                 


Asn Leu Arg Arg Cys Ile Ser Glu Gln His Arg Phe Val Cys Asp Thr 
305                 310                 315                 320 


Cys Asp Lys Ala Phe Pro Met Leu Cys Ser Leu Ala Leu His Lys Gln 
                325                 330                 335     


Thr His Val Ala Ala Asp Gln Gly Gln Glu Lys Pro Gln Ala Thr Pro 
            340                 345                 350         


Leu Pro Gly Asp Ala Leu Asp Gln Lys Gly Phe Leu Ala Leu Leu Gly 
        355                 360                 365             


Leu Gln His Thr Lys Asp Val Arg Pro Ala Pro Ala Glu Glu Pro Leu 
    370                 375                 380                 


Pro Asp Asp Asn Gln Ala Ile Gln Leu Gln Thr Leu Lys Cys Gln Leu 
385                 390                 395                 400 


Pro Gln Asp Pro Gly Cys Thr Asn Leu Leu Ser Leu Ser Pro Phe Glu 
                405                 410                 415     


Ala Ala Ser Leu Gly Gly Ser Leu Thr Val Leu Pro Ala Thr Lys Asp 
            420                 425                 430         


Ser Ile Lys His Leu Ser Leu Gln Pro Phe Gln Lys Gly Phe Ile Ile 
        435                 440                 445             


Gln Pro Asp Ser Ser Ile Val Val Lys Pro Ile Ser Gly Glu Ser Ala 
    450                 455                 460                 


Ile Glu Leu Ala Asp Ile Gln Gln Ile Leu Lys Met Ala Ala Ser Ala 
465                 470                 475                 480 


Pro Pro Gln Ile Ser Leu Pro Pro Phe Ser Lys Ala Pro Ala Ala Pro 
                485                 490                 495     


Leu Gln Ala Ile Phe Lys His Met Pro Pro Leu Lys Pro Lys Pro Leu 
            500                 505                 510         


Val Thr Pro Arg Thr Val Val Ala Thr Ser Thr Pro Pro Pro Leu Ile 
        515                 520                 525             


Asn Ala Gln Gln Ala Ser Pro Gly Cys Ile Ser Pro Ser Leu Pro Pro 
    530                 535                 540                 


Pro Pro Leu Lys Leu Leu Lys Gly Ser Val Glu Ala Ala Ser Asn Ala 
545                 550                 555                 560 


His Leu Leu Gln Ser Lys Ser Gly Thr Gln Pro His Ala Ala Thr Arg 
                565                 570                 575     


Leu Ser Leu Gln Gln Pro Arg Ala Glu Leu Pro Gly Gln Pro Glu Met 
            580                 585                 590         


Lys Thr Gln Leu Glu Gln Asp Ser Ile Ile Glu Ala Leu Leu Pro Leu 
        595                 600                 605             


Ser Met Glu Ala Lys Ile Lys Gln Glu Ile Thr Glu Gly Glu Leu Lys 
    610                 615                 620                 


Ala Phe Met Thr Ala Pro Gly Gly Lys Lys Thr Pro Ala Met Arg Lys 
625                 630                 635                 640 


Val Leu Tyr Pro Cys Arg Phe Cys Asn Gln Val Phe Ala Phe Ser Gly 
                645                 650                 655     


Val Leu Arg Ala His Val Arg Ser His Leu Gly Ile Ser Pro Tyr Gln 
            660                 665                 670         


Cys Asn Ile Cys Asp Tyr Ile Ala Ala Asp Lys Ala Ala Leu Ile Arg 
        675                 680                 685             


His Leu Arg Thr His Ser Gly Glu Arg Pro Tyr Ile Cys Lys Ile Cys 
    690                 695                 700                 


His Tyr Pro Phe Thr Val Lys Ala Asn Cys Glu Arg His Leu Arg Lys 
705                 710                 715                 720 


Lys His Leu Lys Ala Thr Arg Lys Asp Ile Glu Lys Asn Ile Glu Tyr 
                725                 730                 735     


Val Ser Ser Ser Ala Ala Glu Leu Val Asp Ala Phe Cys Ala Pro Asp 
            740                 745                 750         


Thr Val Cys Arg Leu Cys Gly Glu Asp Leu Lys His Tyr Arg Ala Leu 
        755                 760                 765             


Arg Ile His Met Arg Thr His Cys Gly Arg Gly Leu Gly Gly Gly His 
    770                 775                 780                 


Lys Gly Arg Lys Pro Phe Glu Cys Lys Glu Cys Ser Ala Ala Phe Ala 
785                 790                 795                 800 


Ala Lys Arg Asn Cys Ile His His Ile Leu Lys Gln His Leu His Val 
                805                 810                 815     


Pro Glu Gln Asp Ile Glu Ser Tyr Val Leu Ala Ala Asp Gly Leu Gly 
            820                 825                 830         


Pro Ala Glu Ala Pro Ala Ala Glu Ala Ser Gly Arg Gly Glu Asp Ser 
        835                 840                 845             


Gly Cys Ala Ala Leu Gly Asp Cys Lys Pro Leu Thr Ala Phe Leu Glu 
    850                 855                 860                 


Pro Gln Asn Gly Phe Leu His Arg Gly Pro Thr Gln Pro Pro Pro Pro 
865                 870                 875                 880 


His Val Ser Ile Lys Leu Glu Pro Ala Ser Ser Phe Ala Val Asp Phe 
                885                 890                 895     


Asn Glu Pro Leu Asp Phe Ser Gln Lys Gly Leu Ala Leu Val Gln Val 
            900                 905                 910         


Lys Gln Glu Asn Ile Ser Phe Leu Ser Pro Ser Ser Leu Val Pro Tyr 
        915                 920                 925             


Asp Cys Ser Met Glu Pro Ile Asp Leu Ser Ile Pro Lys Asn Phe Arg 
    930                 935                 940                 


Lys Gly Asp Lys Asp Leu Ala Thr Pro Ser Glu Ala Lys Lys Pro Glu 
945                 950                 955                 960 


Glu Glu Ala Gly Ser Ser Glu Gln Pro Ser Pro Cys Pro Ala Pro Gly 
                965                 970                 975     


Pro Ser Leu Pro Val Thr Leu Gly Pro Ser Gly Ile Leu Glu Ser Pro 
            980                 985                 990         


Met Ala Pro Ala Pro Ala Ala Thr  Pro Glu Pro Pro Ala  Gln Pro Leu 
        995                 1000                 1005             


Gln Gly  Pro Val Gln Leu Ala  Val Pro Ile Tyr Ser  Ser Ala Leu 
    1010                 1015                 1020             


Val Ser  Ser Pro Pro Leu Val  Gly Ser Ser Ala Leu  Leu Ser Gly 
    1025                 1030                 1035             


Thr Ala  Leu Leu Arg Pro Leu  Arg Pro Lys Pro Pro  Leu Leu Leu 
    1040                 1045                 1050             


Pro Lys  Pro Pro Val Thr Glu  Glu Leu Pro Pro Leu  Ala Ser Ile 
    1055                 1060                 1065             


Ala Gln  Ile Ile Ser Ser Val  Ser Ser Ala Pro Thr  Leu Leu Lys 
    1070                 1075                 1080             


Thr Lys  Val Ala Asp Pro Gly  Pro Ala Ser Thr Gly  Ser Asn Thr 
    1085                 1090                 1095             


Thr Ala  Ser Asp Ser Leu Gly  Gly Ser Val Pro Lys  Ala Ala Thr 
    1100                 1105                 1110             


Thr Ala  Thr Pro Ala Ala Thr  Thr Ser Pro Lys Glu  Ser Ser Glu 
    1115                 1120                 1125             


Pro Pro  Ala Pro Ala Ser Ser  Pro Glu Ala Ala Ser  Pro Thr Glu 
    1130                 1135                 1140             


Gln Gly  Pro Ala Gly Thr Ser  Lys Lys Arg Gly Arg  Lys Arg Gly 
    1145                 1150                 1155             


Met Arg  Ser Arg Pro Arg Ala  Asn Ser Gly Gly Val  Asp Leu Asp 
    1160                 1165                 1170             


Ser Ser  Gly Glu Phe Ala Ser  Ile Glu Lys Met Leu  Ala Thr Thr 
    1175                 1180                 1185             


Asp Thr  Asn Lys Phe Ser Pro  Phe Leu Gln Thr Ala  Glu Asp Asn 
    1190                 1195                 1200             


Thr Gln  Asp Glu Val Ala Gly  Ala Pro Ala Asp His  His Gly Pro 
    1205                 1210                 1215             


Ser Asp  Glu Glu Gln Gly Ser  Pro Pro Glu Asp Lys  Leu Leu Arg 
    1220                 1225                 1230             


Ala Lys  Arg Asn Ser Tyr Thr  Asn Cys Leu Gln Lys  Ile Thr Cys 
    1235                 1240                 1245             


Pro His  Cys Pro Arg Val Phe  Pro Trp Ala Ser Ser  Leu Gln Arg 
    1250                 1255                 1260             


His Met  Leu Thr His Thr Asp  Ser Gln Ser Asp Ala  Glu Thr Ala 
    1265                 1270                 1275             


Ala Ala  Ala Gly Glu Val Leu  Asp Leu Thr Ser Arg  Asp Arg Glu 
    1280                 1285                 1290             


Gln Pro  Ser Glu Gly Ala Thr  Glu Leu Arg Gln Val  Ala Gly Asp 
    1295                 1300                 1305             


Ala Pro  Val Glu Gln Ala Thr  Ala Glu Thr Ala Ser  Pro Val His 
    1310                 1315                 1320             


Arg Glu  Glu His Gly Arg Gly  Glu Ser His Glu Pro  Glu Glu Glu 
    1325                 1330                 1335             


His Gly  Thr Glu Glu Ser Thr  Gly Asp Ala Asp Gly  Ala Glu Glu 
    1340                 1345                 1350             


Asp Ala  Ser Ser Asn Gln Ser  Leu Asp Leu Asp Phe  Ala Thr Lys 
    1355                 1360                 1365             


Leu Met  Asp Phe Lys Leu Ala  Glu Gly Asp Gly Glu  Ala Gly Ala 
    1370                 1375                 1380             


Gly Gly  Ala Ala Ser Gln Glu  Gln Lys Leu Ala Cys  Asp Thr Cys 
    1385                 1390                 1395             


Gly Lys  Ser Phe Lys Phe Leu  Gly Thr Leu Ser Arg  His Arg Lys 
    1400                 1405                 1410             


Ala His  Gly Arg Gln Glu Pro  Lys Asp Glu Lys Gly  Asp Gly Ala 
    1415                 1420                 1425             


Ser Thr  Ala Glu Glu Gly Pro  Gln Pro Ala Pro Glu  Gln Glu Glu 
    1430                 1435                 1440             


Lys Pro  Pro Glu Thr Pro Ala  Glu Val Val Glu Ser  Ala Pro Gly 
    1445                 1450                 1455             


Ala Gly  Glu Ala Pro Ala Glu  Lys Leu Ala Glu Glu  Thr Glu Gly 
    1460                 1465                 1470             


Pro Ser  Asp Gly Glu Ser Ala  Ala Glu Lys Arg Ser  Ser Glu Lys 
    1475                 1480                 1485             


Ser Asp  Asp Asp Lys Lys Pro  Lys Thr Asp Ser Pro  Lys Ser Val 
    1490                 1495                 1500             


Ala Ser  Lys Ala Asp Lys Arg  Lys Lys Val Cys Ser  Val Cys Asn 
    1505                 1510                 1515             


Lys Arg  Phe Trp Ser Leu Gln  Asp Leu Thr Arg His  Met Arg Ser 
    1520                 1525                 1530             


His Thr  Gly Glu Arg Pro Tyr  Lys Cys Gln Thr Cys  Glu Arg Thr 
    1535                 1540                 1545             


Phe Thr  Leu Lys His Ser Leu  Val Arg His Gln Arg  Ile His Gln 
    1550                 1555                 1560             


Lys Ala  Arg His Ala Lys His  His Gly Lys Asp Ser  Asp Lys Glu 
    1565                 1570                 1575             


Glu Arg  Gly Glu Glu Asp Ser  Glu Asn Glu Ser Thr  His Ser Gly 
    1580                 1585                 1590             


Asn Asn  Ala Val Ser Glu Asn  Glu Ala Glu Leu Ala  Pro Asn Ala 
    1595                 1600                 1605             


Ser Asn  His Met Ala Val Thr  Arg Ser Arg Lys Glu  Gly Leu Ala 
    1610                 1615                 1620             


Ser Ala  Thr Lys Asp Cys Ser  His Arg Glu Glu Lys  Val Thr Ala 
    1625                 1630                 1635             


Gly Trp  Pro Ser Glu Pro Gly  Gln Gly Asp Leu Asn  Pro Glu Ser 
    1640                 1645                 1650             


Pro Ala  Ala Leu Gly Gln Asp  Leu Leu Glu Pro Arg  Ser Lys Arg 
    1655                 1660                 1665             


Pro Ala  His Pro Ile Leu Ala  Thr Ala Asp Gly Ala  Ser Gln Leu 
    1670                 1675                 1680             


Val Gly  Met Glu 
    1685         


<210>  1226
<211>  3285
<212>  DNA
<213>  Homosapiens

<400>  1226
ctagaattca gcggccgctg aattctagac ccggatgaag agtaacgcca ttaccgcccg     60

agccgccgag agccttagcc gacggaaact ggacactgga ccggcagcgc catgagactc    120

ctcccccgct tgctgctgct tctcttactc gtgttccctg ccactgtctt gttccgaggc    180

ggccccagag gctcgttagc agtggcacaa gatcttacag aggatgaaga aacagtagaa    240

gattccataa ttgaggatga agatgatgaa gccgaggtag aagaagatga acccacagat    300

ttggtagaag ataaagagga agaagatgtg tctggtgaac ctgaagcttc accgagtgca    360

gatacaacta tactgtttgt aaaaggagaa gattttccag caaataacat tgtgaagttc    420

ctggtaggct ttaccaacaa gggtacagaa gattttattg ttgaatcctt agatgcctca    480

ttccgttatc ctcaggacca ccagttttat atccagaatt tcacagctct tcctctgaac    540

actgtagtgc caccccagag acaggcaact tttgagtact ctttcattcc tgcagagccc    600

atgggcggac gaccatttgg tttggtcatc aatctgaact acaaagattt gaacggcaat    660

gtattccaag atgcagtctt caatcaaaca gttacagtta ttgaaagaga ggatgggtta    720

gatggagaaa caatctttat gtatatgttc cttgctggtc ttgggcttct ggttattgtt    780

ggccttcatc aactcctaga atctagaaag cgtaagagac ccatacagaa agtagaaatg    840

ggtacatcaa gtcagaatga tgttgacatg agttggattc ctcaggaaac attgaatcaa    900

atcaataaag cttcaccaag aaggttgccc aggaaacggg cacagaagag atcagtggga    960

tctgatgagt aaatgttcct ttgtgcaaca attcggtctt tacttaacct gccctaatat   1020

ttttcggcct gatgggaatt agtgcagaga agccagtcac catagaaggc aactcctact   1080

tgtgtgtgga ctgagcaatc agagtctgtg gcgataatat tgctgaaaat gcactgcatt   1140

catttttcta aagtaacaaa tttggttttt ttttaaacca ttaaaatcta tgtgtgtgcg   1200

tgtgtatgta tgtgagcagt tggtcttacc agaatcattg ttgaactacc tgaaacaagt   1260

ctttagaata ctaaatataa tgctgttgtc tcttcctttt tgacattttc tgattttttc   1320

ccccaaaact cagttaatat ttacccacta tgattattga tgtcctgcct tgaacagttt   1380

taaagaaaac aatttttgga atagctcaaa tttcaattga tggcacaaat cagcattttg   1440

ttgttgttac tgtattacaa ttagtattct aaaggcagaa gcagaagtag ctgcttttta   1500

gcaatagaat tgtttcagta ttttgctgct gtttaatgcg catcttcaga aaacttccca   1560

gtggcttcaa ggaatttggg gatctctctg gcaacaaatt gtgaaacatg aaatttctgc   1620

tgactttaat atatgaaacc taatcctacc ccctttttta acaaaaagaa actagtacat   1680

ttgtgaaaat tgtgttgtgt tgtccattgt tgctctagtt ctgacccaga ggtagctctg   1740

gagtgatttt agacctactc actcagttgt gtgtaggttt ttttgttttg ttttgagaga   1800

gaatttttct ctccttaata gaagcatcct ttttaaagag aagttgcctt ggtccacaca   1860

ctaagcagaa aaccaagtta tcaggacaga gatatttccc agttactcct aatcaatgaa   1920

gaaagtgagt tggatatttt taaagcagtt aactaatttt ttcttaccta atcttttggg   1980

agttttgctt gttgatataa cctttttagt taacctgaaa gattccaaaa attgttctta   2040

agtgcttgag actggaacca aaattaaatt gtacttcata aaatcctctt atagagttac   2100

tcttgcccta gattgtaaat taagtttggc attattgtca gactggatgg agggtgaagt   2160

aaaatagtat gaacaattaa gaggctctcc ccctcttgtc tttaagccat attctcctac   2220

atgtatttta taagaaaatg ttaagtcaaa ttttagtggc tctttaattc ctgacctctt   2280

cattctcctt ttcagtataa cctcccctat gctcatgccc acacagacaa aaaaacaaaa   2340

cgaaatacac acagaaaaaa gtctttccaa actgtttaag tatttaaaca tctgagccaa   2400

agcagataga agttattgta taattgttaa tcactttgca aataggggct atcaaattac   2460

ctatattggc attgctggat tataaactct atatctgtaa tataaagtgt ttgagttttt   2520

aattgggctg ttatgatcag taattgattt tgagaaagct ctatgagctc taagtaactg   2580

catggttttt tgtttaatgt aatataggag acccttcaca ttcccaagga atatattcca   2640

aaacattttt gtgaatatct aagtttgtga aactactagg gcatgataca gtaaggtgta   2700

attacagaat ttacgaaatg taaatggcct ctacagagtt ttatggaata cctggtacta   2760

acgtaggcag ctgcaaaacc acactgagtt acagctgtca gccctcctca ttcctaaata   2820

acttgcctta catatcagcc ctcccacttc tgaagttcaa attagtgcct cggaaatgta   2880

gaatttatta tttgtcattt ttttttttta gcatagattg agaacagttg aactcttaaa   2940

tcctcagatg ccaggggtct gctctagcat cagtaagtat ttagcagaaa ctaactccgt   3000

aatgaatgga attcaattcc acacatggtt tgttcaagca cacttaataa gtagcctatt   3060

ttttaaatgt ctttttaaaa tgtaaatatt tggatgaagt ttttctttgt tttgatatat   3120

tcatttgcta caccaactat gttttcagaa ttcatctttt gaacaacttg gtttcagaat   3180

atgtaaaatg actttaagga tcttgtgtat caaacctatc cccggatgtg tgagaataat   3240

gtgttcataa agcatggatc tcgtaaaaaa aaaaaaaaaa aaaaa                   3285


<210>  1227
<211>  286
<212>  PRT
<213>  Homosapiens

<400>  1227

Met Arg Leu Leu Pro Arg Leu Leu Leu Leu Leu Leu Leu Val Phe Pro 
1               5                   10                  15      


Ala Thr Val Leu Phe Arg Gly Gly Pro Arg Gly Ser Leu Ala Val Ala 
            20                  25                  30          


Gln Asp Leu Thr Glu Asp Glu Glu Thr Val Glu Asp Ser Ile Ile Glu 
        35                  40                  45              


Asp Glu Asp Asp Glu Ala Glu Val Glu Glu Asp Glu Pro Thr Asp Leu 
    50                  55                  60                  


Val Glu Asp Lys Glu Glu Glu Asp Val Ser Gly Glu Pro Glu Ala Ser 
65                  70                  75                  80  


Pro Ser Ala Asp Thr Thr Ile Leu Phe Val Lys Gly Glu Asp Phe Pro 
                85                  90                  95      


Ala Asn Asn Ile Val Lys Phe Leu Val Gly Phe Thr Asn Lys Gly Thr 
            100                 105                 110         


Glu Asp Phe Ile Val Glu Ser Leu Asp Ala Ser Phe Arg Tyr Pro Gln 
        115                 120                 125             


Asp His Gln Phe Tyr Ile Gln Asn Phe Thr Ala Leu Pro Leu Asn Thr 
    130                 135                 140                 


Val Val Pro Pro Gln Arg Gln Ala Thr Phe Glu Tyr Ser Phe Ile Pro 
145                 150                 155                 160 


Ala Glu Pro Met Gly Gly Arg Pro Phe Gly Leu Val Ile Asn Leu Asn 
                165                 170                 175     


Tyr Lys Asp Leu Asn Gly Asn Val Phe Gln Asp Ala Val Phe Asn Gln 
            180                 185                 190         


Thr Val Thr Val Ile Glu Arg Glu Asp Gly Leu Asp Gly Glu Thr Ile 
        195                 200                 205             


Phe Met Tyr Met Phe Leu Ala Gly Leu Gly Leu Leu Val Ile Val Gly 
    210                 215                 220                 


Leu His Gln Leu Leu Glu Ser Arg Lys Arg Lys Arg Pro Ile Gln Lys 
225                 230                 235                 240 


Val Glu Met Gly Thr Ser Ser Gln Asn Asp Val Asp Met Ser Trp Ile 
                245                 250                 255     


Pro Gln Glu Thr Leu Asn Gln Ile Asn Lys Ala Ser Pro Arg Arg Leu 
            260                 265                 270         


Pro Arg Lys Arg Ala Gln Lys Arg Ser Val Gly Ser Asp Glu 
        275                 280                 285     


<210>  1228
<211>  3019
<212>  DNA
<213>  Homosapiens

<400>  1228
ttgcgagttt gtgagagtcc ttggtggagg aggttggaaa gcgttctccc tcccacaaaa     60

cccggtgcag agggagggag agccaggtcc gtagcgtggg tccaagaaac tatggatcct    120

ggaagtgagc acacttttgt gtcttaaaaa gtttggtgtc tcgttttgag gtgaaaaatg    180

aatgagataa gtgcttttta aaaagaagtc ttctattgtt caacagttat gaacaaggac    240

tatcaaaaat tttggtcatc accttcagat cctgtacatt ttgaagtgga tacttctcat    300

gaaaaagtag aaagcatgtc agaatcggat accatgaatg tcagcaatct ttctcaaggt    360

gtaatgcttt cacattctcc aatctgtatg gaaaccaccg gcaccacttg tgacttgcct    420

cagaacgaaa taaagaattt tgaaagggaa aatgagtatg aatccacact ttgtgaagat    480

gcttatggca cactagacaa tttgttaaat gataacaaca ttgaaaatta ctcaacgaat    540

gcactaattc agccagttga caccatcagc atatcttcct tgagacaatt tgaaaccgtt    600

tgcaaatttc actgggtaga agcatttgat gatgaaatga cagagaagcc agaatttcaa    660

agtcaagtgt ataattatgc aaaagacaac aatataaagc aagactcatt taaggaagaa    720

aatccaatgg aaactagtgt ttctgcaaat acagaccaac ttggtaacga gtattttaga    780

cagcctcctc ctagaagccc gcctctaatc cactgcagtg gagagatgct gaaatttaca    840

gaaaagtcac tggctaaaag tattgccaag gaatctgccc tcaaccctag ccaacctcca    900

agcttcttat gtaagactgc agttccttca aaagaaatac agaattatgg ggagattcct    960

gagatgtcag tcagttatga aaaggaagtc acagcagagg gtgtggagag gccagaaatt   1020

gtctcaactt ggtcttcggc aggcatttcc tggaggagtg aagcatgtcg ggagaactgt   1080

gagatgcctg actgggagca aagtgctgaa agcttacaac ctgttcaaga ggacatggct   1140

ttaaatgaag tcttgcagaa attaaaacat actaacagaa agcaggaagt gcgaatccaa   1200

gaactccagt gtagtaacct gtatttagag aagagggtta aagaactaca gatgaagatt   1260

accaaacagc aagtgttcat tgatgtcatc aataagctaa aggagaatgt tgaagaatta   1320

attgaagaca aatacaaaat aatcctagag aagaatgata ctaaaaagac attgcagaat   1380

ttggaagagg ttttagctaa cacgcaaaaa catcttcagg aatccaggaa tgacaaggaa   1440

atgttacagc ttcaatttaa gaagatcaag gctaattatg tgtgtttaca ggaaaggtac   1500

atgactgaaa tgcaacaaaa aaataaatct gtaagtcagt atttagagat ggacaaaacc   1560

ttaagcaaga aagaagaaga ggtagagaga ctacaacaac tcaaaaaaga actggaaaag   1620

gccacagctt ctgctttgga cttgttgaaa cgggaaaaag aggcccaaga acaagagttc   1680

ttgtctttac aggaggaatt ccagaaactt gaaaaggaaa acctggaaga aagacagaaa   1740

ctgaaatcta gacttgagaa attgctcact caagttagaa atttgcaatt tatgtctgaa   1800

aatgaaagaa cgaagaatat aaaacttcag cagcaaatca acgaagtaaa aaatgagaat   1860

gcaaaactta aacagcaggt tgcaaggagt gaagagcaaa attatgtccc taaatttgag   1920

acagctcagt taaaggatca attagaggaa gtcttgaagt cagatattac caaggataca   1980

aaaacgacac attctaatct gctcccggat tgctcacctt gtgaagagag gctgaatcct   2040

gcagatataa aaagagcttc tcagctggcc tccaaaatgc acagtcttct ggctctgatg   2100

gtgggacttc tcacatgcca ggacatcatc aattctgatg ctgaacattt caaagagagt   2160

gagaaggtta gtgatataat gctgcaaaaa ctgaagagcc tccatcttaa aaagaaaact   2220

ttagataaag agctactgaa acataaagat agaatcacaa cctttagaga gttaattgct   2280

aaggaaaaag catttcaaga tcatgctatt aaggtattcc aaggagtatg aaatgattga   2340

aagtgagaac aaatatattt aatctcaggt catagactgt gattcagatg aagccaagag   2400

tatcagagat gtacctaccc ttctgggagc caaactggat aagtaccaca gtctaaatga   2460

ggagcttgat ttcttgatca caaaactggg acatctccta gagtcaaaag aaaaccactg   2520

caacagactc attgaagaaa atgacaagta tcaaagacat ttaggcaact taataaagaa   2580

ggttacatca tatgaagaaa tcattgaatg tgctgaccaa aggcttgcaa tatcccactc   2640

ccagattgca catttggaag agagaaataa acatttagag gatttaatta gaaagcccag   2700

agaaaaagcc agaaaaccaa gatcaaaaag cttagaaaat catccgaagt ccatgaccat   2760

gatgccagct ctttttaaag aaaatagaaa tgatttagat taaacaagcc tgaagattaa   2820

acagtaatca tttttgtcaa ccactccagg aagagtcatt actacatatg ctagccaaat   2880

caatccatgc aggtgatata ttaaaatctg tataaagggt aaagtcttac attccaaaga   2940

tgtgattact tttcttctaa tttcttcctg tgaataatca aatatattct atttaacata   3000

aacggaaaaa aaaaaaaaa                                                3019


<210>  1229
<211>  700
<212>  PRT
<213>  Homosapiens

<400>  1229

Met Asn Lys Asp Tyr Gln Lys Phe Trp Ser Ser Pro Ser Asp Pro Val 
1               5                   10                  15      


His Phe Glu Val Asp Thr Ser His Glu Lys Val Glu Ser Met Ser Glu 
            20                  25                  30          


Ser Asp Thr Met Asn Val Ser Asn Leu Ser Gln Gly Val Met Leu Ser 
        35                  40                  45              


His Ser Pro Ile Cys Met Glu Thr Thr Gly Thr Thr Cys Asp Leu Pro 
    50                  55                  60                  


Gln Asn Glu Ile Lys Asn Phe Glu Arg Glu Asn Glu Tyr Glu Ser Thr 
65                  70                  75                  80  


Leu Cys Glu Asp Ala Tyr Gly Thr Leu Asp Asn Leu Leu Asn Asp Asn 
                85                  90                  95      


Asn Ile Glu Asn Tyr Ser Thr Asn Ala Leu Ile Gln Pro Val Asp Thr 
            100                 105                 110         


Ile Ser Ile Ser Ser Leu Arg Gln Phe Glu Thr Val Cys Lys Phe His 
        115                 120                 125             


Trp Val Glu Ala Phe Asp Asp Glu Met Thr Glu Lys Pro Glu Phe Gln 
    130                 135                 140                 


Ser Gln Val Tyr Asn Tyr Ala Lys Asp Asn Asn Ile Lys Gln Asp Ser 
145                 150                 155                 160 


Phe Lys Glu Glu Asn Pro Met Glu Thr Ser Val Ser Ala Asn Thr Asp 
                165                 170                 175     


Gln Leu Gly Asn Glu Tyr Phe Arg Gln Pro Pro Pro Arg Ser Pro Pro 
            180                 185                 190         


Leu Ile His Cys Ser Gly Glu Met Leu Lys Phe Thr Glu Lys Ser Leu 
        195                 200                 205             


Ala Lys Ser Ile Ala Lys Glu Ser Ala Leu Asn Pro Ser Gln Pro Pro 
    210                 215                 220                 


Ser Phe Leu Cys Lys Thr Ala Val Pro Ser Lys Glu Ile Gln Asn Tyr 
225                 230                 235                 240 


Gly Glu Ile Pro Glu Met Ser Val Ser Tyr Glu Lys Glu Val Thr Ala 
                245                 250                 255     


Glu Gly Val Glu Arg Pro Glu Ile Val Ser Thr Trp Ser Ser Ala Gly 
            260                 265                 270         


Ile Ser Trp Arg Ser Glu Ala Cys Arg Glu Asn Cys Glu Met Pro Asp 
        275                 280                 285             


Trp Glu Gln Ser Ala Glu Ser Leu Gln Pro Val Gln Glu Asp Met Ala 
    290                 295                 300                 


Leu Asn Glu Val Leu Gln Lys Leu Lys His Thr Asn Arg Lys Gln Glu 
305                 310                 315                 320 


Val Arg Ile Gln Glu Leu Gln Cys Ser Asn Leu Tyr Leu Glu Lys Arg 
                325                 330                 335     


Val Lys Glu Leu Gln Met Lys Ile Thr Lys Gln Gln Val Phe Ile Asp 
            340                 345                 350         


Val Ile Asn Lys Leu Lys Glu Asn Val Glu Glu Leu Ile Glu Asp Lys 
        355                 360                 365             


Tyr Lys Ile Ile Leu Glu Lys Asn Asp Thr Lys Lys Thr Leu Gln Asn 
    370                 375                 380                 


Leu Glu Glu Val Leu Ala Asn Thr Gln Lys His Leu Gln Glu Ser Arg 
385                 390                 395                 400 


Asn Asp Lys Glu Met Leu Gln Leu Gln Phe Lys Lys Ile Lys Ala Asn 
                405                 410                 415     


Tyr Val Cys Leu Gln Glu Arg Tyr Met Thr Glu Met Gln Gln Lys Asn 
            420                 425                 430         


Lys Ser Val Ser Gln Tyr Leu Glu Met Asp Lys Thr Leu Ser Lys Lys 
        435                 440                 445             


Glu Glu Glu Val Glu Arg Leu Gln Gln Leu Lys Lys Glu Leu Glu Lys 
    450                 455                 460                 


Ala Thr Ala Ser Ala Leu Asp Leu Leu Lys Arg Glu Lys Glu Ala Gln 
465                 470                 475                 480 


Glu Gln Glu Phe Leu Ser Leu Gln Glu Glu Phe Gln Lys Leu Glu Lys 
                485                 490                 495     


Glu Asn Leu Glu Glu Arg Gln Lys Leu Lys Ser Arg Leu Glu Lys Leu 
            500                 505                 510         


Leu Thr Gln Val Arg Asn Leu Gln Phe Met Ser Glu Asn Glu Arg Thr 
        515                 520                 525             


Lys Asn Ile Lys Leu Gln Gln Gln Ile Asn Glu Val Lys Asn Glu Asn 
    530                 535                 540                 


Ala Lys Leu Lys Gln Gln Val Ala Arg Ser Glu Glu Gln Asn Tyr Val 
545                 550                 555                 560 


Pro Lys Phe Glu Thr Ala Gln Leu Lys Asp Gln Leu Glu Glu Val Leu 
                565                 570                 575     


Lys Ser Asp Ile Thr Lys Asp Thr Lys Thr Thr His Ser Asn Leu Leu 
            580                 585                 590         


Pro Asp Cys Ser Pro Cys Glu Glu Arg Leu Asn Pro Ala Asp Ile Lys 
        595                 600                 605             


Arg Ala Ser Gln Leu Ala Ser Lys Met His Ser Leu Leu Ala Leu Met 
    610                 615                 620                 


Val Gly Leu Leu Thr Cys Gln Asp Ile Ile Asn Ser Asp Ala Glu His 
625                 630                 635                 640 


Phe Lys Glu Ser Glu Lys Val Ser Asp Ile Met Leu Gln Lys Leu Lys 
                645                 650                 655     


Ser Leu His Leu Lys Lys Lys Thr Leu Asp Lys Glu Leu Leu Lys His 
            660                 665                 670         


Lys Asp Arg Ile Thr Thr Phe Arg Glu Leu Ile Ala Lys Glu Lys Ala 
        675                 680                 685             


Phe Gln Asp His Ala Ile Lys Val Phe Gln Gly Val 
    690                 695                 700 


<210>  1230
<211>  2865
<212>  DNA
<213>  Homosapiens

<400>  1230
tggatgttct gtgctctcag gaaggcgtgt tgagtagccg gcacggcgag gcccgtgctg     60

gccgtttctt cccggagttt tcgtttctgt accccacttt gtgtttactg cggcaggagg    120

cgccagctag cccacaggct gttcggccta gggggtcgta ccttcctaac ttcaccactc    180

tctgggaaga caccgcaccc acagtagggt cgctcgggcc tcgcgggctg cacctgtctc    240

tgcggagttc ccccggcgcg ggcggacgtc acacaggggc gttccagcac tccgggagcc    300

cgattgcgag tttgtgagag tccttggtgg aggaggttgg aaagcgttct ccctcccaca    360

aaacccggtg cagagggagg gagagccagg tccgtagcgt gggtccaaga aactatggat    420

cctggaagtg agcacacttt tgtgtcttaa aaagtttggt gtctcgtttt gaggtgaaaa    480

atgaatgaga taagtgcttt ttaaaaagaa cgaaataaag aattttgaaa gggaaaatga    540

gtatgaatcc acactttgtg aagatgctta tggcacacta gacaatttgt taaatgataa    600

caacattgaa aattactcaa cgaatgcact aattcagcca gttgacacca tcagcatatc    660

ttccttgaga caatttgaaa ccgtttgcaa atttcactgg gtagaagcat ttgatgatga    720

aatgacagag aagccagaat ttcaaagtca agtgtataat tatgcaaaag acaacaatat    780

aaagcaagac tcatttaagg aagaaaatcc aatggaaact agtgtttctg caaatacaga    840

ccaacttggt aacgagtatt ttagacagcc tcctcctaga agcccgcctc taatccactg    900

cagtggagag atgctgaaat ttacagaaaa gtcactggct aaaagtattg ccaaggaatc    960

tgccctcaac cctagccaac ctccaagctt cttatgtaag actgcagttc cttcaaaaga   1020

aatacagaat tatggggaga ttcctgagat gtcagtcagt tatgaaaagg aagtcacagc   1080

agagggtgtg gagaggccag aaattgtctc aacttggtct tcggcaggca tttcctggag   1140

gagtgaagca tgtcgggaga actgtgagat gcctgactgg gagcaaagtg ctgaaagctt   1200

acaacctgtt caagaggaca tggctttaaa tgaagtcttg cagaaattaa aacatactaa   1260

cagaaagcag gaagtgcgaa tccaagaact ccagtgtagt aacctgtatt tagagaagag   1320

ggttaaagaa ctacagatga agattaccaa acagcaagtg ttcattgatg tcatcaataa   1380

gctaaaggag aatgttgaag aattaattga agacaaatac aaaataatcc tagagaagaa   1440

tgatactaaa aagacattgc agaatttgga agaggtttta gctaacacgc aaaaacatct   1500

tcaggaatcc aggaatgaca aggaaatgtt acagcttcaa tttaagaaga tcaaggctaa   1560

ttatgtgtgt ttacaggaaa ggtacatgac tgaaatgcaa caaaaaaata aatctgtaag   1620

tcagtattta gagatggaca aaaccttaag caagaaagaa gaagaggtag agagactaca   1680

acaactcaaa aaagaactgg aaaaggccac agcttctgct ttggacttgt tgaaacggga   1740

aaaagaggcc caagaacaag agttcttgtc tttacaggag gaattccaga aacttgaaaa   1800

ggaaaacctg gaagaaagac agaaactgaa atctagactt gagaaattgc tcactcaagt   1860

tagaaatttg caatttatgt ctgaaaatga aagaacgaag aatataaaac ttcagcagca   1920

aatcaacgaa gtaaaaaatg agaatgcaaa acttaaacag caggttgcaa ggagtgaaga   1980

gcaaaattat gtccctaaat ttgagacagc tcagttaaag gatcaattag aggaagtctt   2040

gaagtcagat attaccaagg atacaaaaac gacacattct aatctgctcc cggattgctc   2100

accttgtgaa gagaggctga atcctgcaga tataaaaaga gcttctcagc tggcctccaa   2160

aatgcacagt cttctggctc tgatggtggg acttctcaca tgccaggaca tcatcaattc   2220

tgatgctgaa catttcaaag agagtgagaa ggttagtgat ataatgctgc aaaaactgaa   2280

gagcctccat cttaaaaaga aaactttaga taaagaggtc atagactgtg attcagatga   2340

agccaagagt atcagagatg tacctaccct tctgggagcc aaactggata agtaccacag   2400

tctaaatgag gagcttgatt tcttggttac atcatatgaa gaaatcattg aatgtgctga   2460

ccaaaggctt gcaatatccc actcccagat tgcacatttg gaagagagaa ataaacattt   2520

agaggattta attagaaagc ccagagaaaa agccagaaaa ccaagatcaa aaagcttaga   2580

aaatcatccg aagtccatga ccatgatgcc agctcttttt aaagaaaata gaaatgattt   2640

agattaaaca agcctgaaga ttaaacagta atcatttttg tcaaccactc caggaagagt   2700

cattactaca tatgctagcc aaatcaatcc atgcagatga tatattaaaa tctgtataaa   2760

gggtaaagtc ttacattcca aagatgtgat tacttttctt ctaatttctt cctgtgaata   2820

atcaaatata ttctatttaa cataaacgga aaaaaaaaaa aaaaa                   2865


<210>  1231
<211>  641
<212>  PRT
<213>  Homosapiens

<400>  1231

Met Thr Glu Lys Pro Glu Phe Gln Ser Gln Val Tyr Asn Tyr Ala Lys 
1               5                   10                  15      


Asp Asn Asn Ile Lys Gln Asp Ser Phe Lys Glu Glu Asn Pro Met Glu 
            20                  25                  30          


Thr Ser Val Ser Ala Asn Thr Asp Gln Leu Gly Asn Glu Tyr Phe Arg 
        35                  40                  45              


Gln Pro Pro Pro Arg Ser Pro Pro Leu Ile His Cys Ser Gly Glu Met 
    50                  55                  60                  


Leu Lys Phe Thr Glu Lys Ser Leu Ala Lys Ser Ile Ala Lys Glu Ser 
65                  70                  75                  80  


Ala Leu Asn Pro Ser Gln Pro Pro Ser Phe Leu Cys Lys Thr Ala Val 
                85                  90                  95      


Pro Ser Lys Glu Ile Gln Asn Tyr Gly Glu Ile Pro Glu Met Ser Val 
            100                 105                 110         


Ser Tyr Glu Lys Glu Val Thr Ala Glu Gly Val Glu Arg Pro Glu Ile 
        115                 120                 125             


Val Ser Thr Trp Ser Ser Ala Gly Ile Ser Trp Arg Ser Glu Ala Cys 
    130                 135                 140                 


Arg Glu Asn Cys Glu Met Pro Asp Trp Glu Gln Ser Ala Glu Ser Leu 
145                 150                 155                 160 


Gln Pro Val Gln Glu Asp Met Ala Leu Asn Glu Val Leu Gln Lys Leu 
                165                 170                 175     


Lys His Thr Asn Arg Lys Gln Glu Val Arg Ile Gln Glu Leu Gln Cys 
            180                 185                 190         


Ser Asn Leu Tyr Leu Glu Lys Arg Val Lys Glu Leu Gln Met Lys Ile 
        195                 200                 205             


Thr Lys Gln Gln Val Phe Ile Asp Val Ile Asn Lys Leu Lys Glu Asn 
    210                 215                 220                 


Val Glu Glu Leu Ile Glu Asp Lys Tyr Lys Ile Ile Leu Glu Lys Asn 
225                 230                 235                 240 


Asp Thr Lys Lys Thr Leu Gln Asn Leu Glu Glu Val Leu Ala Asn Thr 
                245                 250                 255     


Gln Lys His Leu Gln Glu Ser Arg Asn Asp Lys Glu Met Leu Gln Leu 
            260                 265                 270         


Gln Phe Lys Lys Ile Lys Ala Asn Tyr Val Cys Leu Gln Glu Arg Tyr 
        275                 280                 285             


Met Thr Glu Met Gln Gln Lys Asn Lys Ser Val Ser Gln Tyr Leu Glu 
    290                 295                 300                 


Met Asp Lys Thr Leu Ser Lys Lys Glu Glu Glu Val Glu Arg Leu Gln 
305                 310                 315                 320 


Gln Leu Lys Lys Glu Leu Glu Lys Ala Thr Ala Ser Ala Leu Asp Leu 
                325                 330                 335     


Leu Lys Arg Glu Lys Glu Ala Gln Glu Gln Glu Phe Leu Ser Leu Gln 
            340                 345                 350         


Glu Glu Phe Gln Lys Leu Glu Lys Glu Asn Leu Glu Glu Arg Gln Lys 
        355                 360                 365             


Leu Lys Ser Arg Leu Glu Lys Leu Leu Thr Gln Val Arg Asn Leu Gln 
    370                 375                 380                 


Phe Met Ser Glu Asn Glu Arg Thr Lys Asn Ile Lys Leu Gln Gln Gln 
385                 390                 395                 400 


Ile Asn Glu Val Lys Asn Glu Asn Ala Lys Leu Lys Gln Gln Val Ala 
                405                 410                 415     


Arg Ser Glu Glu Gln Asn Tyr Val Pro Lys Phe Glu Thr Ala Gln Leu 
            420                 425                 430         


Lys Asp Gln Leu Glu Glu Val Leu Lys Ser Asp Ile Thr Lys Asp Thr 
        435                 440                 445             


Lys Thr Thr His Ser Asn Leu Leu Pro Asp Cys Ser Pro Cys Glu Glu 
    450                 455                 460                 


Arg Leu Asn Pro Ala Asp Ile Lys Arg Ala Ser Gln Leu Ala Ser Lys 
465                 470                 475                 480 


Met His Ser Leu Leu Ala Leu Met Val Gly Leu Leu Thr Cys Gln Asp 
                485                 490                 495     


Ile Ile Asn Ser Asp Ala Glu His Phe Lys Glu Ser Glu Lys Val Ser 
            500                 505                 510         


Asp Ile Met Leu Gln Lys Leu Lys Ser Leu His Leu Lys Lys Lys Thr 
        515                 520                 525             


Leu Asp Lys Glu Val Ile Asp Cys Asp Ser Asp Glu Ala Lys Ser Ile 
    530                 535                 540                 


Arg Asp Val Pro Thr Leu Leu Gly Ala Lys Leu Asp Lys Tyr His Ser 
545                 550                 555                 560 


Leu Asn Glu Glu Leu Asp Phe Leu Val Thr Ser Tyr Glu Glu Ile Ile 
                565                 570                 575     


Glu Cys Ala Asp Gln Arg Leu Ala Ile Ser His Ser Gln Ile Ala His 
            580                 585                 590         


Leu Glu Glu Arg Asn Lys His Leu Glu Asp Leu Ile Arg Lys Pro Arg 
        595                 600                 605             


Glu Lys Ala Arg Lys Pro Arg Ser Lys Ser Leu Glu Asn His Pro Lys 
    610                 615                 620                 


Ser Met Thr Met Met Pro Ala Leu Phe Lys Glu Asn Arg Asn Asp Leu 
625                 630                 635                 640 


Asp 
    


<210>  1232
<211>  2495
<212>  DNA
<213>  Homosapiens

<400>  1232
gggtggtgga tctgtcggtc ccgttttccc gtcgcacgtg gtggccactg ttggcttctg     60

aatggtttgc aaggcggata tccacgccaa ggcctttgga tcggccgtgg gtacatccgt    120

ctgagccgtt cctttccatc gcagagcggc ggcctccggc ggcgctctcc agtcatggac    180

taccggcggc ttctcatgag ccgggtggtc cccgggcaat tcgacgacgc ggactcctct    240

gacagtgaaa acagagactt gaagacagtc aaagagaagg atgacattct gtttgaagac    300

cttcaagaca atgtgaatga gaatggtgaa ggtgaaatag aagatgagga ggaggagggt    360

tatgacgatg atgatgatga ctgggactgg gatgaaggag ttggaaaact cgccaagggt    420

tatgtctgga atggaggaag caacccacag gcaaatcgac agacctccga cagcagttca    480

gccaaaatgt ctactccagc agacaaggtc ttacggaaat ttgagaataa aattaattta    540

gataagctaa atgttactga ttccgtcata aataaagtca ccgaaaagtc tagacaaaag    600

gaagcagata tgtatcgcat caaagataag gcagacagag caactgtaga acaggtgttg    660

gatcccagaa caagaatgat tttattcaag atgttgacta gaggaatcat aacagagata    720

aatggctgca ttagcacagg aaaagaagct aatgtatacc atgctagcac agcaaatgga    780

gagagcagag caatcaaaat ttataaaact tctattttgg tgttcaaaga tcgggataaa    840

tatgtaagtg gagaattcag atttcgtcat ggctattgta aaggaaaccc taggaaaatg    900

gtgaaaactt gggcagaaaa agaaatgagg aacttaatca ggctaaacac agcagagata    960

ccatgtccag aaccaataat gctaagaagt catgttcttg tcatgagttt catcggtaaa   1020

gatgacatgc ctgcaccact cttgaaaaat gtccagttat cagaatccaa ggctcgggag   1080

ttgtacctgc aggtcattca gtacatgaga agaatgtatc aggatgccag acttgtccat   1140

gcagatctca gtgaatttaa catgctgtac cacggtggag gcgtgtatat cattgacgtg   1200

tctcagtccg tggagcacga ccacccacat gccttggagt tcttgagaaa ggattgcgcc   1260

aacgtcaatg atttctttat gaggcacagt gttgctgtca tgactgtgcg ggagctcttt   1320

gaatttgtca cagatccatc cattacacat gagaacatgg atgcttatct ctcaaaggcc   1380

atggaaatag catctcaaag gaccaaggaa gaacggtcta gccaagatca tgtggatgaa   1440

gaggtgttta agcgagcata tattcctaga accttgaatg aagtgaaaaa ttatgagagg   1500

gatatggaca taattatgaa attgaaggaa gaggacatgg ccatgaatgc ccaacaagat   1560

aatattctat accagactgt tacaggattg aagaaagatt tgtcaggagt tcagaaggtc   1620

cctgcactcc tagaaaatca agtggaggaa aggacttgtt ctgattcaga agatattgga   1680

agctctgagt gctctgacac agactctgaa gagcagggag accatgcccg ccccaagaaa   1740

cacaccacgg accctgacat tgataaaaaa gaaagaaaaa agatggtcaa ggaagcccag   1800

agagagaaaa gaaaaaacaa aattcctaaa catgtgaaaa aaagaaagga gaagacagcc   1860

aagacgaaaa aaggcaaata gaatgagaac catattatgt acagtcattt tcctcagttc   1920

cttttctcgc ctgaactctt aagctgcatc tggaagatgg cttattggtt ttaaccagat   1980

tgtcatcgtg gcactgtctg tgaagacgga ttcaaatgtt ttcatgtaac tatgtaaaaa   2040

gctctaagct ctagagtcta gatccagtca ctgactctgt ctggtgttga cagaggattt   2100

atttaagcta ttattttaat aaagaacttt gtacattttt atttttatat ttttttctct   2160

tacaaatatg tttttggaag catgataaat gtttaaatgt agtcaacatc tgtaactctt   2220

acatgagtgt ccagaggcac tcatgggaaa attggttttg ctttctttgt acacaccaga   2280

gacccatctg aggtcatctg attataaggc catgtttata taaagggaat ttcacccaca   2340

gttcagctgg ctgttgattt tcactgcaac tctgcctttg tgtgtattgg cgatcatttg   2400

taatgctctt acacttcgtc tttaatgttc tttttggagt taggacctct cagttcataa   2460

agttttttac aattcaaaaa aaaaaaaaaa aaaaa                              2495


<210>  1233
<211>  568
<212>  PRT
<213>  Homosapiens

<400>  1233

Met Asp Tyr Arg Arg Leu Leu Met Ser Arg Val Val Pro Gly Gln Phe 
1               5                   10                  15      


Asp Asp Ala Asp Ser Ser Asp Ser Glu Asn Arg Asp Leu Lys Thr Val 
            20                  25                  30          


Lys Glu Lys Asp Asp Ile Leu Phe Glu Asp Leu Gln Asp Asn Val Asn 
        35                  40                  45              


Glu Asn Gly Glu Gly Glu Ile Glu Asp Glu Glu Glu Glu Gly Tyr Asp 
    50                  55                  60                  


Asp Asp Asp Asp Asp Trp Asp Trp Asp Glu Gly Val Gly Lys Leu Ala 
65                  70                  75                  80  


Lys Gly Tyr Val Trp Asn Gly Gly Ser Asn Pro Gln Ala Asn Arg Gln 
                85                  90                  95      


Thr Ser Asp Ser Ser Ser Ala Lys Met Ser Thr Pro Ala Asp Lys Val 
            100                 105                 110         


Leu Arg Lys Phe Glu Asn Lys Ile Asn Leu Asp Lys Leu Asn Val Thr 
        115                 120                 125             


Asp Ser Val Ile Asn Lys Val Thr Glu Lys Ser Arg Gln Lys Glu Ala 
    130                 135                 140                 


Asp Met Tyr Arg Ile Lys Asp Lys Ala Asp Arg Ala Thr Val Glu Gln 
145                 150                 155                 160 


Val Leu Asp Pro Arg Thr Arg Met Ile Leu Phe Lys Met Leu Thr Arg 
                165                 170                 175     


Gly Ile Ile Thr Glu Ile Asn Gly Cys Ile Ser Thr Gly Lys Glu Ala 
            180                 185                 190         


Asn Val Tyr His Ala Ser Thr Ala Asn Gly Glu Ser Arg Ala Ile Lys 
        195                 200                 205             


Ile Tyr Lys Thr Ser Ile Leu Val Phe Lys Asp Arg Asp Lys Tyr Val 
    210                 215                 220                 


Ser Gly Glu Phe Arg Phe Arg His Gly Tyr Cys Lys Gly Asn Pro Arg 
225                 230                 235                 240 


Lys Met Val Lys Thr Trp Ala Glu Lys Glu Met Arg Asn Leu Ile Arg 
                245                 250                 255     


Leu Asn Thr Ala Glu Ile Pro Cys Pro Glu Pro Ile Met Leu Arg Ser 
            260                 265                 270         


His Val Leu Val Met Ser Phe Ile Gly Lys Asp Asp Met Pro Ala Pro 
        275                 280                 285             


Leu Leu Lys Asn Val Gln Leu Ser Glu Ser Lys Ala Arg Glu Leu Tyr 
    290                 295                 300                 


Leu Gln Val Ile Gln Tyr Met Arg Arg Met Tyr Gln Asp Ala Arg Leu 
305                 310                 315                 320 


Val His Ala Asp Leu Ser Glu Phe Asn Met Leu Tyr His Gly Gly Gly 
                325                 330                 335     


Val Tyr Ile Ile Asp Val Ser Gln Ser Val Glu His Asp His Pro His 
            340                 345                 350         


Ala Leu Glu Phe Leu Arg Lys Asp Cys Ala Asn Val Asn Asp Phe Phe 
        355                 360                 365             


Met Arg His Ser Val Ala Val Met Thr Val Arg Glu Leu Phe Glu Phe 
    370                 375                 380                 


Val Thr Asp Pro Ser Ile Thr His Glu Asn Met Asp Ala Tyr Leu Ser 
385                 390                 395                 400 


Lys Ala Met Glu Ile Ala Ser Gln Arg Thr Lys Glu Glu Arg Ser Ser 
                405                 410                 415     


Gln Asp His Val Asp Glu Glu Val Phe Lys Arg Ala Tyr Ile Pro Arg 
            420                 425                 430         


Thr Leu Asn Glu Val Lys Asn Tyr Glu Arg Asp Met Asp Ile Ile Met 
        435                 440                 445             


Lys Leu Lys Glu Glu Asp Met Ala Met Asn Ala Gln Gln Asp Asn Ile 
    450                 455                 460                 


Leu Tyr Gln Thr Val Thr Gly Leu Lys Lys Asp Leu Ser Gly Val Gln 
465                 470                 475                 480 


Lys Val Pro Ala Leu Leu Glu Asn Gln Val Glu Glu Arg Thr Cys Ser 
                485                 490                 495     


Asp Ser Glu Asp Ile Gly Ser Ser Glu Cys Ser Asp Thr Asp Ser Glu 
            500                 505                 510         


Glu Gln Gly Asp His Ala Arg Pro Lys Lys His Thr Thr Asp Pro Asp 
        515                 520                 525             


Ile Asp Lys Lys Glu Arg Lys Lys Met Val Lys Glu Ala Gln Arg Glu 
    530                 535                 540                 


Lys Arg Lys Asn Lys Ile Pro Lys His Val Lys Lys Arg Lys Glu Lys 
545                 550                 555                 560 


Thr Ala Lys Thr Lys Lys Gly Lys 
                565             


<210>  1234
<211>  1796
<212>  DNA
<213>  Homosapiens

<400>  1234
aatcaaaatt tataaaactt ctattttggt gttcaaagat cgggataaat atgtaagtgg     60

agaattcagg taagttcaga tttttccctc cagttggttt aatttctatt tcctaaaaca    120

ttaaaataat aatggaatga ttgaaataat aaacattttt cttattcaag atttcgtcat    180

ggctattgta aaggaaaccc taggaaaatg gtgaaaactt gggcagaaaa agaaatgagg    240

aacttaatca ggctaaacac agcagagata ccatgtccag aaccaataat gctaagaagt    300

catgttcttg tcatgagttt catcggtaaa gatgacatgc ctgcaccact cttgaaaaat    360

gtccagttat cagaatccaa ggctcgggag ttgtacctgc aggtcattca gtacatgaga    420

agaatgtatc aggatgccag acttgtccat gcagatctca gtgaatttaa catgctgtac    480

cacggtggag gcgtgtatat cattgacgtg tctcagtccg tggagcacga ccacccacat    540

gccttggagt tcttgagaaa ggattgcgcc aacgtcaatg atttctttat gaggcacagt    600

gttgctgtca tgactgtgcg ggagctcttt gaatttgtca cagatccatc cattacacat    660

gagaacatgg atgcttatct ctcaaaggcc atggaaatag catctcaaag gaccaaggaa    720

gaacggtcta gccaagatca tgtggatgaa gaggtgttta agcgagcata tattcctaga    780

accttgaatg aagtgaaaaa ttatgagagg gatatggaca taattatgaa attgaaggaa    840

gaggacatgg ccatgaatgc ccaacaagat aatattctat accagactgt tacaggattg    900

aagaaagatt tgtcaggagt tcagaaggtc cctgcactcc tagaaaatca agtggaggaa    960

aggacttgtt ctgattcaga agatattgga agctctgagt gctctgacac agactctgaa   1020

gagcagggag accatgcccg ccccaagaaa cacaccacgg accctgacat tgataaaaaa   1080

gaaagaaaaa agatggtcaa ggaagcccag agagagaaaa gaaaaaacaa aattcctaaa   1140

catgtgaaaa aaagaaagga gaagacagcc aagacgaaaa aaggcaaata gaatgagaac   1200

catattatgt acagtcattt tcctcagttc cttttctcgc ctgaactctt aagctgcatc   1260

tggaagatgg cttattggtt ttaaccagat tgtcatcgtg gcactgtctg tgaagacgga   1320

ttcaaatgtt ttcatgtaac tatgtaaaaa gctctaagct ctagagtcta gatccagtca   1380

ctgactctgt ctggtgttga cagaggattt atttaagcta ttattttaat aaagaacttt   1440

gtacattttt atttttatat ttttttctct tacaaatatg tttttggaag catgataaat   1500

gtttaaatgt agtcaacatc tgtaactctt acatgagtgt ccagaggcac tcatgggaaa   1560

attggttttg ctttctttgt acacaccaga gacccatctg aggtcatctg attataaggc   1620

catgtttata taaagggaat ttcacccaca gttcagctgg ctgttgattt tcactgcaac   1680

tctgcctttg tgtgtattgg cgatcatttg taatgctctt acacttcgtc tttaatgttc   1740

tttttggagt taggacctct cagttcataa agttttttac aattcaaaaa aaaaaa       1796


<210>  1235
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  1235

Met Val Lys Thr Trp Ala Glu Lys Glu Met Arg Asn Leu Ile Arg Leu 
1               5                   10                  15      


Asn Thr Ala Glu Ile Pro Cys Pro Glu Pro Ile Met Leu Arg Ser His 
            20                  25                  30          


Val Leu Val Met Ser Phe Ile Gly Lys Asp Asp Met Pro Ala Pro Leu 
        35                  40                  45              


Leu Lys Asn Val Gln Leu Ser Glu Ser Lys Ala Arg Glu Leu Tyr Leu 
    50                  55                  60                  


Gln Val Ile Gln Tyr Met Arg Arg Met Tyr Gln Asp Ala Arg Leu Val 
65                  70                  75                  80  


His Ala Asp Leu Ser Glu Phe Asn Met Leu Tyr His Gly Gly Gly Val 
                85                  90                  95      


Tyr Ile Ile Asp Val Ser Gln Ser Val Glu His Asp His Pro His Ala 
            100                 105                 110         


Leu Glu Phe Leu Arg Lys Asp Cys Ala Asn Val Asn Asp Phe Phe Met 
        115                 120                 125             


Arg His Ser Val Ala Val Met Thr Val Arg Glu Leu Phe Glu Phe Val 
    130                 135                 140                 


Thr Asp Pro Ser Ile Thr His Glu Asn Met Asp Ala Tyr Leu Ser Lys 
145                 150                 155                 160 


Ala Met Glu Ile Ala Ser Gln Arg Thr Lys Glu Glu Arg Ser Ser Gln 
                165                 170                 175     


Asp His Val Asp Glu Glu Val Phe Lys Arg Ala Tyr Ile Pro Arg Thr 
            180                 185                 190         


Leu Asn Glu Val Lys Asn Tyr Glu Arg Asp Met Asp Ile Ile Met Lys 
        195                 200                 205             


Leu Lys Glu Glu Asp Met Ala Met Asn Ala Gln Gln Asp Asn Ile Leu 
    210                 215                 220                 


Tyr Gln Thr Val Thr Gly Leu Lys Lys Asp Leu Ser Gly Val Gln Lys 
225                 230                 235                 240 


Val Pro Ala Leu Leu Glu Asn Gln Val Glu Glu Arg Thr Cys Ser Asp 
                245                 250                 255     


Ser Glu Asp Ile Gly Ser Ser Glu Cys Ser Asp Thr Asp Ser Glu Glu 
            260                 265                 270         


Gln Gly Asp His Ala Arg Pro Lys Lys His Thr Thr Asp Pro Asp Ile 
        275                 280                 285             


Asp Lys Lys Glu Arg Lys Lys Met Val Lys Glu Ala Gln Arg Glu Lys 
    290                 295                 300                 


Arg Lys Asn Lys Ile Pro Lys His Val Lys Lys Arg Lys Glu Lys Thr 
305                 310                 315                 320 


Ala Lys Thr Lys Lys Gly Lys 
                325         


<210>  1236
<211>  2068
<212>  DNA
<213>  Homosapiens

<400>  1236
gacgccacgc aggctgccgt cacccttccg ggtgacatac cggccttggg gtacgcgtgc     60

cttcggggcc tttcctgtgt ttgggaccca gatctcctct cctccagaaa accttgacac    120

tgcccatctt cctcatccag aaggagcgtt cgaggaatgg atgaggtcgg ggtggaagaa    180

acgggtgatt cccttttttt gaaagagcgg aaaccggccg ggcggtttcc agggaggagc    240

atctgttcct cctcgcccgt ttttcgccct cgggctggcg agaactccct caggtcccaa    300

tccgtggact cgcaggggcc atgattgatt ccggagcgca gttaatcaag gcataatggc    360

atggacttga cacagcaagc aaaagacata cagaacataa cagtccagga aaccaacaaa    420

aataactctg aaagcattga atgcagcaaa ataacaatgg atctcaagtt caacaattcc    480

aggaaatata tttctatcac tgtgccatcc aaaacccaaa caatgtcacc acacatcaag    540

tcagttgacg acgttgtggt acttggcatg aatctcagca agtttaacaa acttactcag    600

tttttcatat gtgttgctgg agtttttgta ttttacctaa tttatgggta tttacaggaa    660

ttaatatttt cagtggaggg ttttaagtcc tgtggctggt accttacctt agtgcagttt    720

gccttttact ccatatttgg cctaatagaa cttcagctta ttcaggacaa aaggaggaga    780

ataccaggaa aaacctacat gataatagct tttctaactg tgggtactat ggggttatca    840

aacacttcct tgggctacct gaattaccct acccaagtca tcttcaagtg ctgcaaattg    900

attcctgtta tgctaggagg agtttttatt caaggaaagc gttataatgt tgcagatgtg    960

tctgctgcca tatgtatgag ccttggcctg atatggttta ccctcgctga cagcacaact   1020

gcaccaaatt tcaacctgac gggtgtggtg cttatttccc tggcactatg tgcagatgcc   1080

gtcattggaa atgttcaaga gaaagctatg aaacttcata atgcttctaa ttctgaaatg   1140

gtattgtatt cgtattcaat tggttttgta tacattttac tgggattgac atgcactagt   1200

ggattaggcc ctgcagtaac attttgtgca aagaatccag ttcggaccta tggttatgcg   1260

ttcctttttt ccctcactgg atattttgga atctcctttg ttctggcttt gattaaaatt   1320

tttggtgcac ttattgctgt aacagtgaca acaggaagaa aagcaatgac cattgtactt   1380

tcgtttatat tctttgctaa accattcacg tttcagtatg tatggtctgg tttgttagtt   1440

gtccttggta tatttctcaa tgtttacagc aaaaatatgg ataaaataag actaccatca   1500

ctgtatgatt tgataaacaa atcagtggaa gcaagaaagt caaggacgct ggcacagact   1560

gtatagacag tgattgtcct atttaaaata gaattttaag ggaacaatca tcaattaatt   1620

aactttccaa agggactgat aaaaaccaaa ggatctggag gcattgctat cccatttgtg   1680

ggcagatttc atatgaagtt gttttgcggt gtcagccttt tcttcagagc atttgtttga   1740

ctgacttcca aagcaatcaa gagagccacg tctagcagac tttacaataa aatgtcaata   1800

tgaaggactg taattcctag cagtttattg agaatttcac tggaaatgga ccatgtgttg   1860

caagactaat tggctataat tatatcctat caaagaaatc gatacgtaat agcagattgt   1920

tttatattca ttccattttg atggtgttat ttaaattgat tctctgttat aagagtaaac   1980

tgatgagttg aagtctggag agaataacat tcattataaa taaaattatt ctgtgatctt   2040

taaaaaaaaa aaaaaaaaaa aaaaaaaa                                      2068


<210>  1237
<211>  401
<212>  PRT
<213>  Homosapiens

<400>  1237

Met Asp Leu Thr Gln Gln Ala Lys Asp Ile Gln Asn Ile Thr Val Gln 
1               5                   10                  15      


Glu Thr Asn Lys Asn Asn Ser Glu Ser Ile Glu Cys Ser Lys Ile Thr 
            20                  25                  30          


Met Asp Leu Lys Phe Asn Asn Ser Arg Lys Tyr Ile Ser Ile Thr Val 
        35                  40                  45              


Pro Ser Lys Thr Gln Thr Met Ser Pro His Ile Lys Ser Val Asp Asp 
    50                  55                  60                  


Val Val Val Leu Gly Met Asn Leu Ser Lys Phe Asn Lys Leu Thr Gln 
65                  70                  75                  80  


Phe Phe Ile Cys Val Ala Gly Val Phe Val Phe Tyr Leu Ile Tyr Gly 
                85                  90                  95      


Tyr Leu Gln Glu Leu Ile Phe Ser Val Glu Gly Phe Lys Ser Cys Gly 
            100                 105                 110         


Trp Tyr Leu Thr Leu Val Gln Phe Ala Phe Tyr Ser Ile Phe Gly Leu 
        115                 120                 125             


Ile Glu Leu Gln Leu Ile Gln Asp Lys Arg Arg Arg Ile Pro Gly Lys 
    130                 135                 140                 


Thr Tyr Met Ile Ile Ala Phe Leu Thr Val Gly Thr Met Gly Leu Ser 
145                 150                 155                 160 


Asn Thr Ser Leu Gly Tyr Leu Asn Tyr Pro Thr Gln Val Ile Phe Lys 
                165                 170                 175     


Cys Cys Lys Leu Ile Pro Val Met Leu Gly Gly Val Phe Ile Gln Gly 
            180                 185                 190         


Lys Arg Tyr Asn Val Ala Asp Val Ser Ala Ala Ile Cys Met Ser Leu 
        195                 200                 205             


Gly Leu Ile Trp Phe Thr Leu Ala Asp Ser Thr Thr Ala Pro Asn Phe 
    210                 215                 220                 


Asn Leu Thr Gly Val Val Leu Ile Ser Leu Ala Leu Cys Ala Asp Ala 
225                 230                 235                 240 


Val Ile Gly Asn Val Gln Glu Lys Ala Met Lys Leu His Asn Ala Ser 
                245                 250                 255     


Asn Ser Glu Met Val Leu Tyr Ser Tyr Ser Ile Gly Phe Val Tyr Ile 
            260                 265                 270         


Leu Leu Gly Leu Thr Cys Thr Ser Gly Leu Gly Pro Ala Val Thr Phe 
        275                 280                 285             


Cys Ala Lys Asn Pro Val Arg Thr Tyr Gly Tyr Ala Phe Leu Phe Ser 
    290                 295                 300                 


Leu Thr Gly Tyr Phe Gly Ile Ser Phe Val Leu Ala Leu Ile Lys Ile 
305                 310                 315                 320 


Phe Gly Ala Leu Ile Ala Val Thr Val Thr Thr Gly Arg Lys Ala Met 
                325                 330                 335     


Thr Ile Val Leu Ser Phe Ile Phe Phe Ala Lys Pro Phe Thr Phe Gln 
            340                 345                 350         


Tyr Val Trp Ser Gly Leu Leu Val Val Leu Gly Ile Phe Leu Asn Val 
        355                 360                 365             


Tyr Ser Lys Asn Met Asp Lys Ile Arg Leu Pro Ser Leu Tyr Asp Leu 
    370                 375                 380                 


Ile Asn Lys Ser Val Glu Ala Arg Lys Ser Arg Thr Leu Ala Gln Thr 
385                 390                 395                 400 


Val 
    


<210>  1238
<211>  958
<212>  DNA
<213>  Homosapiens

<400>  1238
cagggggaag agacaagtct ggaaagaacc ctgcccttgg agagactgga ttgaaatctg     60

tgcattgcca agggcaagaa gctgagaaca tggagagaga gaagtttcag cagaaggctc    120

tgaagcaaac taagcagaag aaatccaagt cggctgaatt tctgatggtt aaagaagata    180

gagaagctac agaaggcact ggaaatccag cttttaacat gagcagtcca gatctctcag    240

catgtcagac tgcagaaaag aaagttatta gacacgacat gccggatcgc acccttgcag    300

ctcaccaaca aaaattcagg ctgccagcct ctgcagaacc aaaaggaaat gaatacggca    360

gaaattactt tgacccactg atggatgagg aaataaaccc aaggcagtgt gcgacggagg    420

tcagcagaga agatgacgat agaattttct ataatcgatt aacgaagctt tttgatgaga    480

gcagacaagg agaaccccaa gatgagagtg gccgggagga gactctgaat tctgaagcac    540

ctgggagttc caataagagt cacgaaatcc acaaagaagc cagcgaagcc accactgctc    600

accttgagga gttccaaaga tctcagaaaa ctataattct gcttggaagt tctccattag    660

aacaggaaat tagatctact tcattgcatt gtatggagga tgagatgagt catccatgga    720

tactcttgct caaagtaact gctgtaatca gaagcaggag gtactataga gagcaaagat    780

tctaaaaccc attctcaggt cagtgctcgc aatgttctta tgttcactgt gtcgggaagt    840

tccatgaaca cacaaggcaa catcataagt aggaaaaacc ttcagatttg gtgttagaac    900

tcagagctgt catccttgat tcagatattt atgtgaactt aaacctcttt gtaaaata      958


<210>  1239
<211>  231
<212>  PRT
<213>  Homosapiens

<400>  1239

Met Glu Arg Glu Lys Phe Gln Gln Lys Ala Leu Lys Gln Thr Lys Gln 
1               5                   10                  15      


Lys Lys Ser Lys Ser Ala Glu Phe Leu Met Val Lys Glu Asp Arg Glu 
            20                  25                  30          


Ala Thr Glu Gly Thr Gly Asn Pro Ala Phe Asn Met Ser Ser Pro Asp 
        35                  40                  45              


Leu Ser Ala Cys Gln Thr Ala Glu Lys Lys Val Ile Arg His Asp Met 
    50                  55                  60                  


Pro Asp Arg Thr Leu Ala Ala His Gln Gln Lys Phe Arg Leu Pro Ala 
65                  70                  75                  80  


Ser Ala Glu Pro Lys Gly Asn Glu Tyr Gly Arg Asn Tyr Phe Asp Pro 
                85                  90                  95      


Leu Met Asp Glu Glu Ile Asn Pro Arg Gln Cys Ala Thr Glu Val Ser 
            100                 105                 110         


Arg Glu Asp Asp Asp Arg Ile Phe Tyr Asn Arg Leu Thr Lys Leu Phe 
        115                 120                 125             


Asp Glu Ser Arg Gln Gly Glu Pro Gln Asp Glu Ser Gly Arg Glu Glu 
    130                 135                 140                 


Thr Leu Asn Ser Glu Ala Pro Gly Ser Ser Asn Lys Ser His Glu Ile 
145                 150                 155                 160 


His Lys Glu Ala Ser Glu Ala Thr Thr Ala His Leu Glu Glu Phe Gln 
                165                 170                 175     


Arg Ser Gln Lys Thr Ile Ile Leu Leu Gly Ser Ser Pro Leu Glu Gln 
            180                 185                 190         


Glu Ile Arg Ser Thr Ser Leu His Cys Met Glu Asp Glu Met Ser His 
        195                 200                 205             


Pro Trp Ile Leu Leu Leu Lys Val Thr Ala Val Ile Arg Ser Arg Arg 
    210                 215                 220                 


Tyr Tyr Arg Glu Gln Arg Phe 
225                 230     


<210>  1240
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1240
gaggagagag cagagtatac cgcagacatc atttctacta cagtggcgga gccgtacagg     60

acctgtttca ctgcaggggg atccaaaaca agccccgtgg agcagcagcc agagcaacag    120

cagccgcaag acattgtttc tctccctctg cccccccttc cccacgcaac cccagatcca    180

tttacacttt acagttttac ctcacaaaaa ctactacaag caccaagctc cctgatggaa    240

aggagcatcg tgcatcaagt caccagggtg gtccattcaa gctgcagatt tgtttgtcat    300

ccttgtacag caatctcctc ctccactgcc actacaggga agtgcatcac atgtcagcat    360

actggagcat agtgaaagag tctattttga agcttcaaac ttagtgctgc tgcagaccag    420

gaacaagaga gaaagagtgg atttcagcct gcacggatgg tcttgaaaca caaatggttt    480

ttggtctagg cgttttacac tgagattctc cactgccacc ctttctactc aagcaaaatc    540

ttcgtgaaaa gatctgctgc aaggaactga tagcttatgg ttctccattg tgatgaaagc    600

acatggtaca gttttccaaa gaaattagac cattttcttc gtgagaaaga aatcgacgtg    660

ctgttttcat agggtatttc tcacttctct gtgaaaggaa gaaagaacac gcctgagccc    720

aagagccctc aggagccctc cagagcctgt gggaagtctc catggtgaag tataggctga    780

ggctacctgt gaacagtacg cagtgaatgt tcatccagag ctgctgttgg cggattgtac    840

ccacggggag atgattcctc atgaagagcc tggatcccct acagaaatca aatgtgactt    900

tccgtttatc agactaaaat cagagccatc cagacagtga aacagtcacc gtggaggggg    960

gacggcgaaa aatgaaatcc aaccaagagc ggagcaacga atgcctgcct cccaagaagc   1020

gcgagatccc cgccaccagc cggtcctccg aggagaaggc ccctaccctg cccagcgaca   1080

accaccgggt ggagggcaca gcatggctcc cgggcaaccc tggtggccgg ggccacgggg   1140

gcgggaggca tgggccggca gggacctcgg tggagcttgg tttacaacag ggaataggtt   1200

tacacaaagc attgtccaca gggctggact actccccgcc cagcgctccc aggtctgtcc   1260

ccgtggccac cacgctgcct gccgcgtacg ccaccccgca gccagggacc ccggtgtccc   1320

ccgtgcagta cgctcacctg ccgcacacct tccagttcat tgggtcctcc caatacagtg   1380

gaacctatgc cagcttcatc ccatcacagc tgatcccccc aaccgccaac cccgtcacca   1440

gtgcagtggc ctcggccgca ggggccacca ctccatccca gcgctcccag ctggaggcct   1500

attccactct gctggccaac atgggcagtc tgagccagac gccgggacac aaggctgagc   1560

agcagcagca gcagcagcag cagcagcagc agcagcatca gcatcagcag cagcagcagc   1620

agcagcagca gcagcagcag cagcagcacc tcagcagggc tccggggctc atcaccccgg   1680

ggtccccccc accagcccag cagaaccagt acgtccacat ttccagttct ccgcagaaca   1740

ccggccgcac cgcctctcct ccggccatcc ccgtccacct ccacccccac cagacgatga   1800

tcccacacac gctcaccctg gggcccccct cccaggtcgt catgcaatac gccgactccg   1860

gcagccactt tgtccctcgg gaggccacca agaaagctga gagcagccgg ctgcagcagg   1920

ccatccaggc caaggaggtc ctgaacggtg agatggagaa gagccggcgg tacggggccc   1980

cgtcctcagc cgacctgggc ctgggcaagg caggcggcaa gtcggttcct cacccgtacg   2040

agtccaggca cgtggtggtc cacccgagcc cctcagacta cagcagtcgt gatccttcgg   2100

gggtccgggc ctctgtgatg gtcctgccca acagcaacac gcccgcagct gacctggagg   2160

tgcaacaggc cactcatcgt gaagcctccc cttctaccct caacgacaaa agtggcctgc   2220

atttagggaa gcctggccac cggtcctacg cgctctcacc ccacacggtc attcagacca   2280

cacacagtgc ttcagagcca ctcccggtgg gactgccagc cacggccttc tacgcaggga   2340

ctcaaccccc tgtcatcggc tacctgagcg gccagcagca agcaatcacc tacgccggca   2400

gcctgcccca gcacctggtg atccccggca cacagcccct gctcatcccg gtcggcagca   2460

ctgacatgga agcgtcgggg gcagccccgg ccatagtcac gtcatccccc cagtttgctg   2520

cagtgcctca cacgttcgtc accaccgccc ttcccaagag cgagaacttc aaccctgagg   2580

ccctggtcac ccaggccgcc tacccagcca tggtgcaggc ccagatccac ctgcctgtgg   2640

tgcagtccgt ggcctccccg gcggcggctc cccctacgct gcctccctac ttcatgaaag   2700

gctccatcat ccagttggcc aacggggagc taaagaaggt ggaagactta aaaacagaag   2760

atttcatcca gagtgcagag ataagcaacg acctgaagat cgactccagc accgtagaga   2820

ggattgaaga cagccatagc ccgggcgtgg ccgtgataca gttcgccgtc ggggagcacc   2880

gagcccaggt cagcgttgaa gttttggtag agtatccttt ttttgtgttt ggacagggct   2940

ggtcatcctg ctgtccggag agaaccagcc agctctttga tttgccgtgt tccaaactct   3000

cagttgggga tgtctgcatc tcgcttaccc tcaagaacct gaagaacggc tctgttaaaa   3060

agggccagcc cgtggatccc gccagcgtcc tgctgaagca ctcaaaggcc gacggcctgg   3120

cgggcagcag acacaggtat gccgagcagg aaaacggaat caaccagggg agtgcccaga   3180

tgctctctga gaatggcgaa ctgaagtttc cagagaaaat gggattgcct gcagcgccct   3240

tcctcaccaa aatagaaccc agcaagcccg cggcaacgag gaagaggagg tggtcggcgc   3300

cagagagccg caaactggag aagtcagaag acgaaccacc tttgactctt cctaagcctt   3360

ctctaattcc tcaggaggtt aagatttgca ttgaaggccg gtctaatgta ggcaagtaga   3420

ggcagcgtgg gggaaaggaa acgtggctct cccttatcat ttgtatccag attactgtac   3480

tgtaggctaa aataacacag tatttacatg ttatcttctt aattttaggt ttctgttcta   3540

accttgtcat tagagttaca gcaggtgtgt cgcaggagac tggtgcatat gctttttcca   3600

cgagtgtctg tcagtgagcg ggcgggagga agggcacagc aggagcggtc agggctccag   3660

gcatccccgg ggaagaaagg aacggggctt cacagtgcct gccttctcta gcggcacaga   3720

agcagccggg ggcgctgact cccgctagtg tcaggagaaa agtcccgtgg gaagagtcct   3780

gcaggggtgc agggttgcac gcatgtgggg gtgcacaggc gctgtggcgg cgagtgaggg   3840

tctctttttc tctgcctccc tctgcctcac tctcttgcta tcggcatggg ccgggggggt   3900

tcagagcagt gtcctcctgg ggttcccacg tgcaaaatca acatcaggaa cccagcttca   3960

gggcatcgcg gagacgcgtc agatggcaga tttggaaagt taaccattta aaagaacatt   4020

tttctctcca acatatttta caataaaagc aacttttaat tgtatagata tatatttccc   4080

cctatggggc ctgactgcac tgatatatat tttttttaaa gagcaactgc cacatgcggg   4140

atttcatttc tgctttttac tagtgcagcg atgtcaccag ggtgttgtgg tggacaggga   4200

agcccctgct gtcatggccc cacatggggt aaggggggtt gggggtgggg gagagggaga   4260

gagcgaacac ccacgctggt ttctgtgcag tgttaggaaa accaatcagg ttattgcatt   4320

gacttcactc ccaagaggta gatgcaaact gcccttcagt gagagcaaca gaagctcttc   4380

acgttgagtt tgcgaaatct ttttgtcttt gaactctagt actgtttata gttcatgact   4440

atggacaact cgggtgccac tttttttttt tttcagattc cagtgtgaca tgaggaatta   4500

gattttgaag atgagcatat attactatct ttaagcattt aaaaatactg ttcacacttt   4560

attaccaagc atcttggtct ctcattcaac aagtactgta tctcacttta aactctttgg   4620

ggaaaaaaca aaaacaaaaa aaactaagtt gctttctttt tttcaacact gtaactacat   4680

ttcagctctg cagaattgct gaagagcaag atattgaaag tttcaatgtg gtttaaaggg   4740

atgaatgtga attatgaact agtatgtgac aataaatgac caccaagtac tacctgacgg   4800

gaggcacttt tcactttgat gtctgagaat cagttcaagg catatgcaga gttggcagag   4860

aaactgagag aaaagggatg gagaagagaa tactcatttt tgtccagtgt ttttcttttt   4920

aagatgaact tttaaagaac cttgcgattt gcacatattg agtttataac ttgtgtgata   4980

ttcctgcagt ttttatccaa taacattgtg ggaaaggttt gggggactga acgagcataa   5040

ataaatgtag caaaatttct ttctaacctg cctaaactct aggccatttt ataaggttat   5100

gttcctttga aaattcattt tggtcttttt accacatctg tcacaaaaag ccaggtctta   5160

gcgggctctt agaaactctg agaattttct tcagattcat tgagagagtt ttccataaag   5220

acatttatat atgtgagcaa gatttttttt aaacaattac tttattattg ttgttattaa   5280

tgttattttc agaatggctt ttttttttct attcaaaatc aaatcgagat ttaatgtttg   5340

gtacaaaccc agaaagggta tttcatagtt tttaaacctt tcattcccag agatccgaaa   5400

tatcatttgt gggttttgaa tgcatcttta aagtgcttta aaaaaaagtt ttataagtag   5460

ggagaaattt ttaaatattc ttacttggat ggctgcaact aaactgaaca aatacctgac   5520

ttttctttta ccccattgaa aatagtactt tcttcgtttc acaaattaaa aaaaaaatct   5580

ggtatcaacc cacattttgg ctgtctagta ttcatttaca tttagggttc accaggacta   5640

atgattttta taaaccgttt tctggggtgt accaaaaaca tttgaatagg tttagaatag   5700

ctagaatagt tccttgactt tcctcgaatt tcattaccct ctcagcatgc ttgcagagag   5760

ctgggtgggc tcattcttgc agtcatactg cttatttagt gctgtatttt ttaaacgttt   5820

ctgttcagag aacttgctta atcttccata tattctgctc agggcacttg caattattag   5880

gttttgtttt tctttttgtt ttttagcctt tgatggtaag aggaatacgg gctgccacat   5940

agactttgtt ctcattaata tcactattta caactcatgt ggactcagaa aaacacacac   6000

caccttttgg cttacttcga gtattgaatt gactggatcc actaaaccaa cactaagatg   6060

ggaaaacaca catggtttgg agcaatagga acatcatcat aatttttgtg gttctatttc   6120

aggtatagga attataaaat aattggttct ttctaaacac ttgtcccatt tcattctctt   6180

gcttttttag catgtgcaat actttctgtg ccaatagagt ctgaccagtg tgctatatag   6240

ttaaagctca ttcccttttg gctttttcct tgtttggttg atcttcccca ttctggccag   6300

agcagggctg gagggaagga gccaggaggg agagagcctc ccacctttcc cctgctgcgg   6360

atgctgagtg ctggggcggg gagccttcag gagccccgtg cgtctgccgc cacgttgcag   6420

aaagagccag ccaaggagac ccgggggagg aaccgcagtg tcccctgtca ccacacggaa   6480

tagtgaatgt ggagtgtgga gaggaaggag gcagattcat ttctaagacg cactctggag   6540

ccatgtagcc tggagtcaac ccattttcca cggtcttttc tgcaagtggg caggcccctc   6600

ctcggggtct gtgtccttga gacttggagc cctgcctctg agcctggacg ggaagtgtgg   6660

cctgttgtgt gtgtgcgttc tgagcgtgtt ggccagtggc tgtggagggg accacctgcc   6720

acccacggtc accactccct tgtggcagct ttctcttcaa ataggaagaa cgcacagagg   6780

gcaggagcct cctgtttgca gacgttggcg ggccccgagg ctcccagagc agcctctgtc   6840

accgcttctg tgtagcaaac attaacgatg acaggggtag aaattcttcg gtgccgttca   6900

gcttacaagg atcagccatg tgcctctgta ctatgtccac tttgcaatat ttaccgacag   6960

ccgtcttttg ttctttcttt cctgttttcc atttttaaac tagtaacagc aggccttttg   7020

cgtttacaat ggaacacaat caccaagaaa ttagtcaggg cgaaaagaaa aaaataatac   7080

tattaataag aaaccaacaa acaagaacct ctctttctag ggatttctaa atatataaaa   7140

tgactgttcc ttagaatgtt taacttaaga attatttcag tttgtctggg ccacactggg   7200

gcagaggggg gagggaggga tacagagatg gatgccactt acctcagatc ttttaaagtg   7260

gaaatccaaa ttgaattttc atttggactt tcaggataat tttctatgtt ggtcaacttt   7320

tcgttttccc taactcaccc agtttagttt gggatgattt gatttctgtt gttgttgatc   7380

ccatttctaa cttggaattg tgagcctcta tgttttctgt taggtgagtg tgttgggttt   7440

tttcccccca ccaggaagtg gcagcatccc tccttctccc ctaaagggac tctgcggaac   7500

ctttcacacc tctttctcag ggacggggca ggtgtgtgtg tggtacactg acgtgtccag   7560

aagcagcact ttgactgctc tggagtaggg ttgtacaatt tcaaggaatg tttggatttc   7620

ctgcatcttg tggattactc cttagatacc gcatagattg caatataatg ctgcatgttc   7680

aagatgaaca gtagctccta gtaatcataa aatccactct ttgcacagtt tgatctttac   7740

tgaaatatgt tgccaaaatt tatttttgtt gttgtagctc tggattttgt tttgttttgt   7800

tttttaagga aacgattgac aatacccttt aacatctgtg actactaagg aaacctattt   7860

ctttcataga gagaaaaatc tccaatgctt ttgaagacac taataccgtg ctatttcaga   7920

tatgggtgag gaagcagagc tctcggtacc gaaggccggg cttcttgagc tgtgttggtt   7980

gtcatggcta ctgtttcatg aaccacaagc agctcaacag actggtctgt tgccttctga   8040

aaccctttgc acttcaattt gcaccaggtg aaaacagggc cagcagactc catggcccaa   8100

ttcggtttct tcggtggtga tgtgaaagga gagaattaca cttttttttt ttttaagtgg   8160

cgtggaggcc tttgcttcca catttgtttt ta                                 8192


<210>  1241
<211>  815
<212>  PRT
<213>  Homosapiens

<400>  1241

Met Lys Ser Asn Gln Glu Arg Ser Asn Glu Cys Leu Pro Pro Lys Lys 
1               5                   10                  15      


Arg Glu Ile Pro Ala Thr Ser Arg Ser Ser Glu Glu Lys Ala Pro Thr 
            20                  25                  30          


Leu Pro Ser Asp Asn His Arg Val Glu Gly Thr Ala Trp Leu Pro Gly 
        35                  40                  45              


Asn Pro Gly Gly Arg Gly His Gly Gly Gly Arg His Gly Pro Ala Gly 
    50                  55                  60                  


Thr Ser Val Glu Leu Gly Leu Gln Gln Gly Ile Gly Leu His Lys Ala 
65                  70                  75                  80  


Leu Ser Thr Gly Leu Asp Tyr Ser Pro Pro Ser Ala Pro Arg Ser Val 
                85                  90                  95      


Pro Val Ala Thr Thr Leu Pro Ala Ala Tyr Ala Thr Pro Gln Pro Gly 
            100                 105                 110         


Thr Pro Val Ser Pro Val Gln Tyr Ala His Leu Pro His Thr Phe Gln 
        115                 120                 125             


Phe Ile Gly Ser Ser Gln Tyr Ser Gly Thr Tyr Ala Ser Phe Ile Pro 
    130                 135                 140                 


Ser Gln Leu Ile Pro Pro Thr Ala Asn Pro Val Thr Ser Ala Val Ala 
145                 150                 155                 160 


Ser Ala Ala Gly Ala Thr Thr Pro Ser Gln Arg Ser Gln Leu Glu Ala 
                165                 170                 175     


Tyr Ser Thr Leu Leu Ala Asn Met Gly Ser Leu Ser Gln Thr Pro Gly 
            180                 185                 190         


His Lys Ala Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        195                 200                 205             


His Gln His Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln His Leu Ser Arg Ala Pro Gly Leu Ile Thr Pro Gly Ser Pro Pro 
225                 230                 235                 240 


Pro Ala Gln Gln Asn Gln Tyr Val His Ile Ser Ser Ser Pro Gln Asn 
                245                 250                 255     


Thr Gly Arg Thr Ala Ser Pro Pro Ala Ile Pro Val His Leu His Pro 
            260                 265                 270         


His Gln Thr Met Ile Pro His Thr Leu Thr Leu Gly Pro Pro Ser Gln 
        275                 280                 285             


Val Val Met Gln Tyr Ala Asp Ser Gly Ser His Phe Val Pro Arg Glu 
    290                 295                 300                 


Ala Thr Lys Lys Ala Glu Ser Ser Arg Leu Gln Gln Ala Ile Gln Ala 
305                 310                 315                 320 


Lys Glu Val Leu Asn Gly Glu Met Glu Lys Ser Arg Arg Tyr Gly Ala 
                325                 330                 335     


Pro Ser Ser Ala Asp Leu Gly Leu Gly Lys Ala Gly Gly Lys Ser Val 
            340                 345                 350         


Pro His Pro Tyr Glu Ser Arg His Val Val Val His Pro Ser Pro Ser 
        355                 360                 365             


Asp Tyr Ser Ser Arg Asp Pro Ser Gly Val Arg Ala Ser Val Met Val 
    370                 375                 380                 


Leu Pro Asn Ser Asn Thr Pro Ala Ala Asp Leu Glu Val Gln Gln Ala 
385                 390                 395                 400 


Thr His Arg Glu Ala Ser Pro Ser Thr Leu Asn Asp Lys Ser Gly Leu 
                405                 410                 415     


His Leu Gly Lys Pro Gly His Arg Ser Tyr Ala Leu Ser Pro His Thr 
            420                 425                 430         


Val Ile Gln Thr Thr His Ser Ala Ser Glu Pro Leu Pro Val Gly Leu 
        435                 440                 445             


Pro Ala Thr Ala Phe Tyr Ala Gly Thr Gln Pro Pro Val Ile Gly Tyr 
    450                 455                 460                 


Leu Ser Gly Gln Gln Gln Ala Ile Thr Tyr Ala Gly Ser Leu Pro Gln 
465                 470                 475                 480 


His Leu Val Ile Pro Gly Thr Gln Pro Leu Leu Ile Pro Val Gly Ser 
                485                 490                 495     


Thr Asp Met Glu Ala Ser Gly Ala Ala Pro Ala Ile Val Thr Ser Ser 
            500                 505                 510         


Pro Gln Phe Ala Ala Val Pro His Thr Phe Val Thr Thr Ala Leu Pro 
        515                 520                 525             


Lys Ser Glu Asn Phe Asn Pro Glu Ala Leu Val Thr Gln Ala Ala Tyr 
    530                 535                 540                 


Pro Ala Met Val Gln Ala Gln Ile His Leu Pro Val Val Gln Ser Val 
545                 550                 555                 560 


Ala Ser Pro Ala Ala Ala Pro Pro Thr Leu Pro Pro Tyr Phe Met Lys 
                565                 570                 575     


Gly Ser Ile Ile Gln Leu Ala Asn Gly Glu Leu Lys Lys Val Glu Asp 
            580                 585                 590         


Leu Lys Thr Glu Asp Phe Ile Gln Ser Ala Glu Ile Ser Asn Asp Leu 
        595                 600                 605             


Lys Ile Asp Ser Ser Thr Val Glu Arg Ile Glu Asp Ser His Ser Pro 
    610                 615                 620                 


Gly Val Ala Val Ile Gln Phe Ala Val Gly Glu His Arg Ala Gln Val 
625                 630                 635                 640 


Ser Val Glu Val Leu Val Glu Tyr Pro Phe Phe Val Phe Gly Gln Gly 
                645                 650                 655     


Trp Ser Ser Cys Cys Pro Glu Arg Thr Ser Gln Leu Phe Asp Leu Pro 
            660                 665                 670         


Cys Ser Lys Leu Ser Val Gly Asp Val Cys Ile Ser Leu Thr Leu Lys 
        675                 680                 685             


Asn Leu Lys Asn Gly Ser Val Lys Lys Gly Gln Pro Val Asp Pro Ala 
    690                 695                 700                 


Ser Val Leu Leu Lys His Ser Lys Ala Asp Gly Leu Ala Gly Ser Arg 
705                 710                 715                 720 


His Arg Tyr Ala Glu Gln Glu Asn Gly Ile Asn Gln Gly Ser Ala Gln 
                725                 730                 735     


Met Leu Ser Glu Asn Gly Glu Leu Lys Phe Pro Glu Lys Met Gly Leu 
            740                 745                 750         


Pro Ala Ala Pro Phe Leu Thr Lys Ile Glu Pro Ser Lys Pro Ala Ala 
        755                 760                 765             


Thr Arg Lys Arg Arg Trp Ser Ala Pro Glu Ser Arg Lys Leu Glu Lys 
    770                 775                 780                 


Ser Glu Asp Glu Pro Pro Leu Thr Leu Pro Lys Pro Ser Leu Ile Pro 
785                 790                 795                 800 


Gln Glu Val Lys Ile Cys Ile Glu Gly Arg Ser Asn Val Gly Lys 
                805                 810                 815 


<210>  1242
<211>  2034
<212>  DNA
<213>  Homosapiens

<400>  1242
agaaccagct atgtcggcct acggcatgcc catgtacaag agcggggacc tggtgtttgc     60

caagttaaag ggctatgccc actggccggc ggggatagag cgcatgaccc agcccaaccg    120

ctaccaggtg tttttcttcg ggacccacga gacggccttc ctgagtccca aacgcctgtt    180

cccgtacaag gagtgcaagg agaagttcgg caagcccaac aagaggcgcg gcttcagcgc    240

ggggctgtgg gaaatcgaga acaaccccac ggtccaggcc tcctactgcc cattagcctc    300

agagaagggc agcggagacg ggccttggcc ggagcccgag gccgcagagg gcgacgagga    360

caagccgacc cacgctggtg gcggcggcga cgaattgggg aagccggacg acgacaagcc    420

cactgaggag gagaaggggc cgctgaagag gagcgcgggg gacccgccgg aggacgcccc    480

caaacgaccc aaggaggcag cccccgacca agaggaggag gcggaggcgg agagggcggc    540

ggaagcggag agggcggcgg cggcggcggc ggcgacggcc gtcgacgagg agagtccgtt    600

ccccgtggcg gtggagaacg gcagcgcccc tagcgagccg ggcctggtct gcgagccgcc    660

tcagccagag gaggaggagc tccgggagga agaagtcgcg gacgaggagg cctcccagga    720

gtggcatgcc gaggcaccgg gcggcggaga tcgcgacagc ctgtagttac cagcgtttcc    780

agaagagccc ctgccccgtt cctgctgcgg cctggccgtt cttggggaat ctgaccacgg    840

cgtgcaaact gggactgcct ttccctctcc tcagcccgtc ctcctccaac ccgcgctcct    900

ttgccctgcc gggccccagg atggcaggcc acctgactct cacctctgtg cccccagctt    960

ccggctccct cttctccccc ctctacccgc caccccaccc caccccaccc ccgcccactc   1020

gttgcctgat tccgtttccg acttggggtt caggcaggct gttttcacct ctagacaccc   1080

ctctccaccc ctcctgcttc cccaggcatt atgaacctct gcttaggaat atgggtagga   1140

gtgaaaggcc tggcagataa agagcagagg gcacttgcag ggcctgggat gagcagtctt   1200

caagctgtgg tagttagcgg gcaggagagc gacatcttcc tgagctcctg tccatgcctg   1260

ccatacctgc cagcttcaga catttaggga aaaggggcag catgtgggga atgccccccg   1320

ccttccacaa atccttttgc tgacccagga agttctggga gttgccgttt ttcatcaaaa   1380

cgtttggggg cttccaagtt gtttgtgaga tctgaaaact taactttgcc caatatcctg   1440

gttggggacc gtgagaaata tctgtcccat ttagatctct ggggccactg atgggatgcc   1500

ctgggaagat ccttggctgc cgctttctct ccccacagcc tcaaggccac cctaccgtca   1560

tatatatcac tcaggcgtag aagaaaagac acatatttta taaaatcttt ttaataaaag   1620

gaagttccaa gaagaatttt taagaactac ctctaggtgt gcctccacgc tggccctagc   1680

tttcccattg ctgttccatt gctgagacaa actggaaggc tccctttctg tttgaagttt   1740

tatgacttgt agtcaggctt tgctgttcgt cacagtgtca ttttccattc aggtaccatc   1800

acctggtccc atcaacaggt ctagtatgta gctcactgat aacagaggaa gatgtgtctc   1860

ctcccaccct cttcctaatg gtcattatgc ctttctccat ctattgtctc tttcacccct   1920

tcccctctcc cttgggctct gatgaaaaat tgttgactgc agtttcggaa gtttgatctg   1980

agaaccaacc atagaatgtt tcagttctag gaaataaaac cagttgatta aagc         2034


<210>  1243
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  1243

Met Ser Ala Tyr Gly Met Pro Met Tyr Lys Ser Gly Asp Leu Val Phe 
1               5                   10                  15      


Ala Lys Leu Lys Gly Tyr Ala His Trp Pro Ala Gly Ile Glu Arg Met 
            20                  25                  30          


Thr Gln Pro Asn Arg Tyr Gln Val Phe Phe Phe Gly Thr His Glu Thr 
        35                  40                  45              


Ala Phe Leu Ser Pro Lys Arg Leu Phe Pro Tyr Lys Glu Cys Lys Glu 
    50                  55                  60                  


Lys Phe Gly Lys Pro Asn Lys Arg Arg Gly Phe Ser Ala Gly Leu Trp 
65                  70                  75                  80  


Glu Ile Glu Asn Asn Pro Thr Val Gln Ala Ser Tyr Cys Pro Leu Ala 
                85                  90                  95      


Ser Glu Lys Gly Ser Gly Asp Gly Pro Trp Pro Glu Pro Glu Ala Ala 
            100                 105                 110         


Glu Gly Asp Glu Asp Lys Pro Thr His Ala Gly Gly Gly Gly Asp Glu 
        115                 120                 125             


Leu Gly Lys Pro Asp Asp Asp Lys Pro Thr Glu Glu Glu Lys Gly Pro 
    130                 135                 140                 


Leu Lys Arg Ser Ala Gly Asp Pro Pro Glu Asp Ala Pro Lys Arg Pro 
145                 150                 155                 160 


Lys Glu Ala Ala Pro Asp Gln Glu Glu Glu Ala Glu Ala Glu Arg Ala 
                165                 170                 175     


Ala Glu Ala Glu Arg Ala Ala Ala Ala Ala Ala Ala Thr Ala Val Asp 
            180                 185                 190         


Glu Glu Ser Pro Phe Pro Val Ala Val Glu Asn Gly Ser Ala Pro Ser 
        195                 200                 205             


Glu Pro Gly Leu Val Cys Glu Pro Pro Gln Pro Glu Glu Glu Glu Leu 
    210                 215                 220                 


Arg Glu Glu Glu Val Ala Asp Glu Glu Ala Ser Gln Glu Trp His Ala 
225                 230                 235                 240 


Glu Ala Pro Gly Gly Gly Asp Arg Asp Ser Leu 
                245                 250     


<210>  1244
<211>  746
<212>  DNA
<213>  Homosapiens

<400>  1244
gatctgacta acctctttca ttctttgccc tatgttatat ggcttagacc aaagcctgag     60

acatttaacc aatttataaa tattaaatgc agaaggcata ctttatcagt tcctggaaac    120

atcaaagaag ctggaagggg aatggaaatt ggatggcact ttgtggaggt cactttgctg    180

acagtcaagt attcaaagat ctcctaagat acccggtctt taaagtatta tacaaaatat    240

caggcccagt cccaaggcgc aacttgtgcc agcagcccgc gccagcagcc tgcaccagca    300

aaatagcagt agcaagaaga gagccagcag aagacaccta ccctggccgg aagacgcgta    360

cccctgaaga ttgaggaaga ggccatccgg gtacaacgta gcagttacgt cagactaaga    420

cacttcctgt ttataggaga ctataaaacc tttgccctgt cctcactagg ggctgacacc    480

attttagtcc tcagaccgcc tgcacccagg cgctcattaa aacagcatgt tgcttccacc    540

gcctcatgtt gtctgttggc gcgctctcgg ggttcgaacc agtacaagaa ccttagatat    600

atgatactgc acctaataaa aatagtctaa aataacaaca gccaatatag gcacaaacct    660

gaaagtgtct gcatagaagt aacacatcca tgtacttgat aaactaaagt gtagatattt    720

tatgcggaat aaactttgaa gtgagg                                         746


<210>  1245
<211>  73
<212>  PRT
<213>  Homosapiens

<400>  1245

Met Ala Leu Cys Gly Gly His Phe Ala Asp Ser Gln Val Phe Lys Asp 
1               5                   10                  15      


Leu Leu Arg Tyr Pro Val Phe Lys Val Leu Tyr Lys Ile Ser Gly Pro 
            20                  25                  30          


Val Pro Arg Arg Asn Leu Cys Gln Gln Pro Ala Pro Ala Ala Cys Thr 
        35                  40                  45              


Ser Lys Ile Ala Val Ala Arg Arg Glu Pro Ala Glu Asp Thr Tyr Pro 
    50                  55                  60                  


Gly Arg Lys Thr Arg Thr Pro Glu Asp 
65                  70              


<210>  1246
<211>  285
<212>  DNA
<213>  Homosapiens

<400>  1246
atgatggtgg caattgactc tgagatggtg ggcacaggac ccaaggggca tgttagtttc     60

ttggctcaat gtagcattgt caactacaac ggagatgtgc tttatgatga gtacatcctt    120

cccccctgcc acactgtgga ctactggacc agatggagtg gtatccagaa gcagcacatg    180

gtgaatgcca cacccttcaa gattgctcgg ggccagatct tgaagatact cacagggaag    240

atagtggtgg ggcatgccat ccacgacgac ctcaaagccc tttag                    285


<210>  1247
<211>  2358
<212>  DNA
<213>  Homosapiens

<400>  1247
aaaagctgga accctgcccc tttggagggg gaggcggcgg cggcggcggc ggcggcggcg     60

gcggctgcgc gggcctcggg tgcgcgggca cgcgggactc ccagctgtca atcaggcgcg    120

ggctgagctc tacgaggcgg agcggcggcg gtggcgacgg cgatgggacc ccagcgagag    180

atctgcagct aggctggctg cacttgctcc acgggtcagg ggatcggagg gggattgaag    240

aatgcgccat taaaaggaaa gatcaaggag taaaccagaa gaagaagaaa aagaggactt    300

caaagctggg aaggatgagt tcttgcagca acgtctgtgg gtccaggcag gcacaggctg    360

cagctgaggg tggttaccag cgctatggag tccggtccta cctgcaccag ttttatgagg    420

actgtacagc ctcaatttgg gagtatgagg atgatttcca gatccaaaga tcacctaaca    480

ggtggagctc agtattctgg aaggttggac tcatctcagg tacagttttt gtgatcctcg    540

gattgactgt tctggcagtg ggctttcttg tgccccccaa aatcgaagca tttggcgaag    600

ccgattttgt ggtggtcgac acacatgctg tccagtttaa cagtgctctg gacatgtaca    660

agctggcagg agctgttctc ttctgcattg gaggcacgtc catggcaggg tgcctgctga    720

tgtcggtgtt tgtaaagagc tactccaaag aagaaaaatt cctccagcag aagtttaaag    780

aacgaatcgc agacaccaaa gcccacaccc agccggttac aaaagctcca gggccagggg    840

aaacaaagat tccagtcact ttgtccaggg ttcaaaatgt ccagcctcta ctggcaacct    900

gaaacctttc ccaccccagt tcttcttgtc tgatttatgc ccgtggttaa aaagagcagg    960

ccagttttcg agataaagaa gatttggcgt tgactgccct agggctgtgt tcagctgtgg   1020

gcaatataat gggtggactc acacttgctc agttcaggca gctctgctgg agggcggtgc   1080

catgcctaag cctgtgcaca tgcatccagc tgcttaagat gggtgcttcc ttgtacccgg   1140

ccaccagaaa acccctggaa ctcctctttc atagatcgtg actttgtgtt attttccgtg   1200

ttgtttgaaa gtgccgaaca gtttagacca gctcaccaat ggctaatgtg gtccatttta   1260

ttttctaata ttggtttatc taatgttttc tgcgtggtgc cgtcttccat tcctgtctca   1320

ctatgtgtaa gattttgtca tatgtgttca tagaaacatg gaattctctg attttgagcc   1380

gaacatgagt ttttagactg tatcttgaca tgaggttcct gacattggat acaaagttat   1440

cagcattcac aaatcttttt gttttctcca ttttttttcc ctttgagatg aagtgctgtt   1500

cttttgccta ggttggagta cagcggtgaa atcatagcgc actgcagcct tgaactcctg   1560

ggctcaagcg atcctcccac ctcagcctcc caagtagctg ggactacagg cacctgccac   1620

cacccccagt taatattttt tttaattttt tttagaggca ggatcttgct gtccaatttt   1680

ttttaaaaag ctaaaattgc caactttaga atcttgacca aaaaaaatta attttaggag   1740

catctattta tgcagtgttc aaaagtactg aattagaaac caggaagttt tagttccttc   1800

tactacctgt gtgatcttgg ggaaattatt taacctctca gtcctaattt tccccttctg   1860

tataatggga gttctggatc acaatatgtc tgggctctca ttacccaaac atctgagatt   1920

ccatttttgc catgtgtcat cgagtcgctc cccaacagat gtttgtgatg tttttgtggc   1980

tgtcaccatg gtgggattct ttcagaatga gactcctgga aattcactga gtcagcagcc   2040

ttcacaccat ctacccttaa atatccaacc ccagcaattt atacaacgct gtcatatttt   2100

taaaaaaaca aaagtaagcc atcctcaaat aaggaacccc ttggtagata ttaaccttaa   2160

aaagggtttt cattctcaaa caagatgctt tgttctccaa caagatgttc gtctcatcac   2220

ttgcactttt gttttaatgt atggattcag attagactga gaaaaatgga tggtattttc   2280

ttaaaattgt gccaccttaa agcccccccc cttttttttt tcttccttca ctggataaat   2340

aaaatatgtg aacaagtg                                                 2358


<210>  1248
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  1248

Met Ser Ser Cys Ser Asn Val Cys Gly Ser Arg Gln Ala Gln Ala Ala 
1               5                   10                  15      


Ala Glu Gly Gly Tyr Gln Arg Tyr Gly Val Arg Ser Tyr Leu His Gln 
            20                  25                  30          


Phe Tyr Glu Asp Cys Thr Ala Ser Ile Trp Glu Tyr Glu Asp Asp Phe 
        35                  40                  45              


Gln Ile Gln Arg Ser Pro Asn Arg Trp Ser Ser Val Phe Trp Lys Val 
    50                  55                  60                  


Gly Leu Ile Ser Gly Thr Val Phe Val Ile Leu Gly Leu Thr Val Leu 
65                  70                  75                  80  


Ala Val Gly Phe Leu Val Pro Pro Lys Ile Glu Ala Phe Gly Glu Ala 
                85                  90                  95      


Asp Phe Val Val Val Asp Thr His Ala Val Gln Phe Asn Ser Ala Leu 
            100                 105                 110         


Asp Met Tyr Lys Leu Ala Gly Ala Val Leu Phe Cys Ile Gly Gly Thr 
        115                 120                 125             


Ser Met Ala Gly Cys Leu Leu Met Ser Val Phe Val Lys Ser Tyr Ser 
    130                 135                 140                 


Lys Glu Glu Lys Phe Leu Gln Gln Lys Phe Lys Glu Arg Ile Ala Asp 
145                 150                 155                 160 


Thr Lys Ala His Thr Gln Pro Val Thr Lys Ala Pro Gly Pro Gly Glu 
                165                 170                 175     


Thr Lys Ile Pro Val Thr Leu Ser Arg Val Gln Asn Val Gln Pro Leu 
            180                 185                 190         


Leu Ala Thr 
        195 


<210>  1249
<211>  4612
<212>  DNA
<213>  Homosapiens

<400>  1249
tgccatcttg gctcaccgca acctctgcct tccaggttca agcaattctc ctgccttagc     60

ctcctgagta gctgggatta caggcatgcg ccaccacgcc caggaggcga tcccgcgccc    120

tgggtgcggt gaggccgctg ggacagcgga ggtgcctccc gacgcgaagc agcgagctga    180

ggcggcggcc agcggggaag atgagcggca gcagcgccag gtccagccac ctgtctcagc    240

ccgtcgtgaa gagcgtgctt gtgtaccgca acggggaccc cttctacgcg gggcgccgcg    300

tcgtcatcca tgagaagaag gtgtccagct tcgaagtctt cctgaaggag gtgaccggcg    360

gcgttcaggc accctttggg gccgtcagga acatctacac cccgcggact ggccaccgaa    420

tccggaagct agaccagatc cagagcgggg gcaattacgt ggctggaggc caggaagcct    480

tcaagaaact caattacttg gacataggag aaatcaagaa aagaccaatg gaagttgtta    540

atacagaggt aaaaccagta atccatagca ggatcaacgt gtcagctcgc tttagaaaac    600

cgcttcagga gccgtgcact atcttcttga ttgcaaatgg agacctcata aacccagctt    660

ctcgcctcct tatccccaga aaaaccttga atcagtggga tcatgtacta caaatggtca    720

cagaaaaaat cactctgagg agcggggctg ttcacaggct ttatacttta gaaggaaaac    780

ttgttgagag tggagcagag ttggagaatg ggcagtttta tgtggctgtt ggcagagata    840

agtttaagaa actgccttac ggtgagttac tttttgacaa gtcaacgatg agaaggcctt    900

ttggtcagaa agcttcttca ctacctccta ttgtaggatc cagaaagtct aaagggagtg    960

gaaatgatcg ccactctaag tcaacagttg gatccagtga caactcatct cctcagcccc   1020

tgaagaggaa agggaaaaaa gaagacgtga attcagaaaa actgacgaaa ttgaaacaaa   1080

atgtaaaatt aaagaattca caagaaacca ttccaaatag tgatgaaggc attttcaaag   1140

ctggagcaga gaggtctgaa acacgggggg cagcagaagt ccaagaagat gaagatactc   1200

aggttgaggt tccagtcgat cagaggccag cagaaatagt agacgaggaa gaagatggag   1260

agaaggcaaa caaggatgca gaacagaaag aagacttttc aggaatgaat ggtgaccttg   1320

aagaggaagg aggtagggag gctacagatg cccctgagca agtcgaggag attctggatc   1380

acagtgagca gcaggcacgc cctgctcgtg taaatggagg caccgatgag gagaatggtg   1440

aggagctgca gcaggttaat aatgagcttc aactggtcct agacaaggaa agaaagtctc   1500

aaggagctgg cagtggacaa gatgaggctg atgtagaccc tcaaagacca ccaaggccag   1560

aagtaaaaat taccagtcca gaagaaaatg aaaacaacca acaaaacaag gactatgctg   1620

ccgtggctta gaacattttt aaaaagagag tatatggatc gcaagaaaaa tgaagggtta   1680

tcatacttga aagataagca catagttatt gctgaatata atgtgacact atggtcgaat   1740

actacctacg aattataaca ttagaagcct agtggaaaga ccagataact ttaaatggct   1800

actaaaggat aattacttac ttttattgca tgtgttttaa aagtcatata gaaatattaa   1860

ataagacgga cagaggagaa tttgcactgg aagacaattg ccacttgtaa aggatgaaaa   1920

ataggatcac tcttattgta cgctttatta taagtttaga aggcagttta ttctaaataa   1980

tttttctcta ggaaggcgta gaattttaaa gaactggtaa taggaaagca tgtactattt   2040

tcttaaagca ataaactctt gaatgaacag attgcgattt actttcagac ataatttgga   2100

gatggcagta gatcaaaatg tgtccatgac ttgttaacat gcctttcttt cttcctcctt   2160

agccaaaatc cacctttgaa ctacaaagac agagcaaggc gttcattttg gtgggaggaa   2220

gcattggttc agagtgttag tgactagtat cgccatgccg tcacttaaat gctttcaggc   2280

ttgcatgctt gtggctccaa tggcgcacac tcaggaagga attgtaaagg agcacccagt   2340

tatattataa agcctggatg tatggtttgc agataatgga aatcctgtgg attttcactg   2400

atccagtcta tctttaccaa tagtatctct ctcttctccc ttatgttatt agagaacctg   2460

atattggcta ttccaaagat taaattattt tcaaatagtt ttcaacaaaa ataaaagtgt   2520

attaggaaga aaaaagtaga ctatatgaag agtttgtgac tgctcaattt aacttgtttt   2580

ttgccttatt tctattaaga ctgttttact atgtttttgc cctagggata tcagcaaata   2640

tttatttttc ctagcatgat atagttagaa tttcaagcag atttctttgt aattagaagg   2700

catctgatag aaattgtaaa actttagaag ttattataat gaaaccaatt cctgaatcac   2760

aacttcatgg actgactaaa ttgatttata gttgccttgt gaggtatgta tggggaaaac   2820

ataaaaacat aattaaaaca taatttcgtc ctttttatga attcttaaga gatgttcttc   2880

cataaatata gaaataatat atttttctta aaggatatat ttttaattat gtggaagttg   2940

taagcttgaa attttaactt ctagtgcttt tctaaaattc acaattacaa gtttaaaaca   3000

ttttttctct tccaggtttc atttggaata aagagttggc agttatataa agcacttaat   3060

aatactatag aaaatagatg tgttttttct taatatgatt ttggtatttt ccacagatca   3120

gaagtgtaaa cagagagata atgtaacagt atttggaaga gataatgaca caaggatata   3180

gtgatctggg agcatgaatt agaaacaggg tactatgttt ctggtgtaaa atctaaattg   3240

tgctttctac tagcgttact ttttcaaatg ggatgatata aagcactgtg ggctataagc   3300

aacaatcttg ggttggtagg caaatagacc aattgatctt tattattatt attattatta   3360

ttattattat tttttgagat gaagtcttgc tcttgtcgcc caggctgggt gcagtggcat   3420

gatcttggct tactgcaacc tctgcctcct gggttcaagc acctgagcct cccgagtagc   3480

tgggattaca ggcatctgcc accacacctg gctaattttt gtattttttg tagagacaga   3540

tgtttcacca tgttggccag gctggtctca aactcctgac ctcaggtgat ccgcccgcct   3600

ttgcatccca aaatgctggg attacaggtg tgagccacag cacccggtcc cagttggtct   3660

tttaatatta aatttgtgca ctattactgg gtctggagtt aatgatttca aatagtttct   3720

aaaaataact gattaaatgt aagaaattat aactaattat caaggtgatt ctcttttgtt   3780

tcttcaatgg agagtttctc tttctctttt cctcctctaa taaaaatatt tctttttttc   3840

ctgtcctttt attcattata ttatgaaact taggttttag gaaacacctt aagcgtcatt   3900

ttaatgaagc acaacattga tattttacat gaataataac gtttggtatt ttaaatatac   3960

ttcaaggggg taataagcca caataactgt accaaaaaaa cttaaaaatg gggacatatt   4020

catcccttgt gtgtgcatat tttaccactt gttgacaaga tacaattgtg acctactttg   4080

aggggatgaa taacgactta tcactttaag acactttgca aacatgttac taaaaaaagg   4140

tgcctagcca aggaaaaaac cattcacttg gaattaaaat tgtggatgtc acttcagaga   4200

tgactttaac ataaatgctg aaagttcatt cacctcacaa atgtggcagt tttctctgtg   4260

gagaatggtg gtctccgtgg cagactggct ctccaaatta aatgaaactc attgacagac   4320

ctgggacctt ttatgtgagt ggacagacaa gatcttggtt tggcttcatg tactgttttc   4380

tagagagagt gctacgaaaa acttatgatg cttttatgtg ataaccaata taatgcttta   4440

atatgttaat tctttgtgat gctatataca tagtttttat agttttatga aaccactttg   4500

ttaaacttat ctggatttta agacacttgt aaacaaatgg tttgttagta aaattggggc   4560

attaagagtt ttacagagca aataaagaag attttgacaa aagtcaaaaa aa           4612


<210>  1250
<211>  476
<212>  PRT
<213>  Homosapiens

<400>  1250

Met Ser Gly Ser Ser Ala Arg Ser Ser His Leu Ser Gln Pro Val Val 
1               5                   10                  15      


Lys Ser Val Leu Val Tyr Arg Asn Gly Asp Pro Phe Tyr Ala Gly Arg 
            20                  25                  30          


Arg Val Val Ile His Glu Lys Lys Val Ser Ser Phe Glu Val Phe Leu 
        35                  40                  45              


Lys Glu Val Thr Gly Gly Val Gln Ala Pro Phe Gly Ala Val Arg Asn 
    50                  55                  60                  


Ile Tyr Thr Pro Arg Thr Gly His Arg Ile Arg Lys Leu Asp Gln Ile 
65                  70                  75                  80  


Gln Ser Gly Gly Asn Tyr Val Ala Gly Gly Gln Glu Ala Phe Lys Lys 
                85                  90                  95      


Leu Asn Tyr Leu Asp Ile Gly Glu Ile Lys Lys Arg Pro Met Glu Val 
            100                 105                 110         


Val Asn Thr Glu Val Lys Pro Val Ile His Ser Arg Ile Asn Val Ser 
        115                 120                 125             


Ala Arg Phe Arg Lys Pro Leu Gln Glu Pro Cys Thr Ile Phe Leu Ile 
    130                 135                 140                 


Ala Asn Gly Asp Leu Ile Asn Pro Ala Ser Arg Leu Leu Ile Pro Arg 
145                 150                 155                 160 


Lys Thr Leu Asn Gln Trp Asp His Val Leu Gln Met Val Thr Glu Lys 
                165                 170                 175     


Ile Thr Leu Arg Ser Gly Ala Val His Arg Leu Tyr Thr Leu Glu Gly 
            180                 185                 190         


Lys Leu Val Glu Ser Gly Ala Glu Leu Glu Asn Gly Gln Phe Tyr Val 
        195                 200                 205             


Ala Val Gly Arg Asp Lys Phe Lys Lys Leu Pro Tyr Gly Glu Leu Leu 
    210                 215                 220                 


Phe Asp Lys Ser Thr Met Arg Arg Pro Phe Gly Gln Lys Ala Ser Ser 
225                 230                 235                 240 


Leu Pro Pro Ile Val Gly Ser Arg Lys Ser Lys Gly Ser Gly Asn Asp 
                245                 250                 255     


Arg His Ser Lys Ser Thr Val Gly Ser Ser Asp Asn Ser Ser Pro Gln 
            260                 265                 270         


Pro Leu Lys Arg Lys Gly Lys Lys Glu Asp Val Asn Ser Glu Lys Leu 
        275                 280                 285             


Thr Lys Leu Lys Gln Asn Val Lys Leu Lys Asn Ser Gln Glu Thr Ile 
    290                 295                 300                 


Pro Asn Ser Asp Glu Gly Ile Phe Lys Ala Gly Ala Glu Arg Ser Glu 
305                 310                 315                 320 


Thr Arg Gly Ala Ala Glu Val Gln Glu Asp Glu Asp Thr Gln Val Glu 
                325                 330                 335     


Val Pro Val Asp Gln Arg Pro Ala Glu Ile Val Asp Glu Glu Glu Asp 
            340                 345                 350         


Gly Glu Lys Ala Asn Lys Asp Ala Glu Gln Lys Glu Asp Phe Ser Gly 
        355                 360                 365             


Met Asn Gly Asp Leu Glu Glu Glu Gly Gly Arg Glu Ala Thr Asp Ala 
    370                 375                 380                 


Pro Glu Gln Val Glu Glu Ile Leu Asp His Ser Glu Gln Gln Ala Arg 
385                 390                 395                 400 


Pro Ala Arg Val Asn Gly Gly Thr Asp Glu Glu Asn Gly Glu Glu Leu 
                405                 410                 415     


Gln Gln Val Asn Asn Glu Leu Gln Leu Val Leu Asp Lys Glu Arg Lys 
            420                 425                 430         


Ser Gln Gly Ala Gly Ser Gly Gln Asp Glu Ala Asp Val Asp Pro Gln 
        435                 440                 445             


Arg Pro Pro Arg Pro Glu Val Lys Ile Thr Ser Pro Glu Glu Asn Glu 
    450                 455                 460                 


Asn Asn Gln Gln Asn Lys Asp Tyr Ala Ala Val Ala 
465                 470                 475     


<210>  1251
<211>  1382
<212>  DNA
<213>  Homosapiens

<400>  1251
cattatgcta acagcataaa catgcagggg gtgggagcag ggtcacaaaa gtgagtgttg     60

tcaattctac ttggaatgaa aggttgaaat aatttaaaca gtacgggaaa tgcagagcaa    120

ttttctcctc tggtgacaat atagtgtcca acacttggaa gtgattttta agaatgttta    180

tttaaattaa aaggatggat ttccaaggaa aaaaaataag gaaaaggaaa gaaaaaactg    240

aacagaaaac gcaaaagtat cagtttggtc actaaccttt gcaaggatac ctttttattt    300

tctttaagat tcctgttgtt tatacacaga ttttaagttt actcctactg ctgacccaag    360

tgaaattcct tctccagtca cagtgtcaac ctctaccccc caactgcaac gagagttttg    420

aggggcatca atcacaccga gaagtcacag cccctcaacc actgaggtgt gggggggtag    480

ggatctgcat ttcttcatat caaccccaca ctatagggca cctaaatggg tgggcggtgg    540

gggagaccga ctcacttgag tttcttgaag gcttcctggc ctccagccac gtaattgccc    600

ccgctctgga tctggtctag cttccggatt cggtggccag tccgcggggt gtagatgttc    660

ctgacggccc caaagggtgc ctgaacgccg ccggtcacct ccttcaggaa gacttcgaag    720

ctggacacct tcttctcatg gatgacgacg cggcgccccg cgtagaaggg gtccccgttg    780

cggtacacaa gcacgctctt cacgacgggc tgagacaggt ggctggacct ggcgctgctg    840

ccgctcatct tccccgctgg ccgccgcctc agctcgctgc ttcgcgtcgg gaggcacctc    900

cgctgtccca gcggcctcac cgcacccagg gcgcgggatc gcctcctgaa acgaacgaga    960

aactgacgaa tccacaggtg aaagagaagt aacggccgtg cgcctaggcg tccacccaga   1020

ggagacacta ggagcttgca ggactcggag tagacgctca agtttttcac cgtggcgtgc   1080

acagccaatc aggacccgca gtgcgcgcac cacaccaggt tcacctgcta cgggcagaat   1140

caaggtggac agcttctgag caggagccgg aaacgcgcgg ggccttcaaa caggcacgcc   1200

tagtgagggc aggagagagg aggacgcaca cacacacaca cacacaaata tggtgaaacc   1260

caatttctta catcatatct gtgctaccct ttccaaacag cctaattttt cttttctctc   1320

ttcttgcacc tttacccctc aatctcctgc ttcctcccaa attaaagcaa ttaagttcct   1380

gg                                                                  1382


<210>  1252
<211>  84
<212>  PRT
<213>  Homosapiens

<400>  1252

Met Asp Asp Asp Ala Ala Pro Arg Val Glu Gly Val Pro Val Ala Val 
1               5                   10                  15      


His Lys His Ala Leu His Asp Gly Leu Arg Gln Val Ala Gly Pro Gly 
            20                  25                  30          


Ala Ala Ala Ala His Leu Pro Arg Trp Pro Pro Pro Gln Leu Ala Ala 
        35                  40                  45              


Ser Arg Arg Glu Ala Pro Pro Leu Ser Gln Arg Pro His Arg Thr Gln 
    50                  55                  60                  


Gly Ala Gly Ser Pro Pro Glu Thr Asn Glu Lys Leu Thr Asn Pro Gln 
65                  70                  75                  80  


Val Lys Glu Lys 
                


<210>  1253
<211>  3348
<212>  DNA
<213>  Homosapiens

<400>  1253
atgcctggtg cacagagtct gcaggtcggg cggtagcgac aggtcagagc tgcggcctga     60

gcagccagcg tccggcatga aggtctgggg tctggctgct gcctgcttct tgctccagca    120

ccatggaatg cctgcgcagt ttaccctgcc tcctgccccg cgcgatgaga cttccccggc    180

ggacgctgtg tgccctggcc ttggacgtga cctctgtggg tcctcccgtt gctgcctgcg    240

gccgccgagc caacctgatt ggaaggagcc gagcggcgca gctttgcggg cccgaccggc    300

tccgcgtggc aggtgaagtg caccggttta gaacctctga cgtctctcaa gccactttag    360

ccagtgtagc cccagtattt actgtgacaa aatttgacaa acagggaaac gttacttctt    420

ttgaaaggaa gaaaactgaa ttataccaag agttaggtct tcaagccaga gatttgagat    480

ttcagcatgt aatgagtatc acagtcagaa acaataggat tatcatgaga atggagtatt    540

tgaaagctgt gataactcca gagtgtcttc tgatattaga ttatcgtaat ttaaacttag    600

agcaatggct gttccgggaa ctcccttcac agttgtctgg agagggtcaa ctcgttacat    660

accctttacc ttttgagttt agagctatag aagcactcct gcaatattgg atcaacaccc    720

ttcaggggaa acttagcatt ttgcagccac tgatccttga gaccttggat gctttggtgg    780

accccaaaca ttcttctgta gacagaagca aactgcacat tttactacag aatggcaaaa    840

gtctatcaga gttagaaaca gatattaaaa ttttcaaaga gtcaattttg gagatcttgg    900

atgaggaaga gttgctagaa gagctctgtg tatcaaaatg gagtgaccca caagtctttg    960

aaaagagcag tgctgggatt gaccatgcag aagagatgga gttgctgttg gaaaactact   1020

accgattggc tgacgatctc tccaatgcag ctcgtgagct tagggtgctg attgatgatt   1080

cacaaagtat tattttcatt aatctggaca gccaccgaaa cgtgatgatg aggttgaatc   1140

tacagctgac catgggaacc ttctctcttt cgctctttgg actaatggga gttgcttttg   1200

gaatgaattt ggaatcttcc cttgaagagg accatagaat tttttggctg attacaggaa   1260

ttatgttcat gggaagtggc ctcatctgga ggcgcctgct ttcattcctt ggacgacagc   1320

tagaagctcc attgcctcct atgatggctt ctttacctaa aaagactctt ctggcagata   1380

gaagcatgga attgaaaaat agcctcagac tggatggact tggatcagga aggagcatcc   1440

taacaaaccg ttaggaacag ccccgtggat actgaagttt tttttatggt agttacagga   1500

aacttctgat actcttttta ttattttctt gtatagagtc agacacttga aaaaaactaa   1560

tgtttgaaga caaaaatatt ttggcagtca caataccaga actggattgc atttccagaa   1620

ttctgagtta aagaaacaaa gtatttgctt tgtaaaaggc caaaattcta tttcctacaa   1680

actttaaatg ctgtttttat agatgtgata tgaggcaaca caagcacaga cagttgcata   1740

gattttaatt tatacatatc aagaaaagtg caatttcatg ctgaatgaag cgtaggaact   1800

tgacaagccc ataggtagct atagttcttt gtcagtatag ggaattatgt tcatgtgaat   1860

ttcctgattc tcaggtgact aaaaagctag cattctatgt attaacctta caacagactc   1920

tgtaagtttg agctttaaaa accaaacttt gacataacct tatttcttgt atttgccccc   1980

ttttttttat aaaaggtgaa taaaaagaaa taatttaata tcaccattgt atggattcct   2040

aatcaagatt tcacgttctc agcccctgag actagttttc tttgctctct gtaattagag   2100

cctttggaag caaagttgaa aggaagtatt tccattctgt tactgttttg tagcactttg   2160

tccatttatt gatttttaaa gtagatattt agataccacc cctgccctgc cccaaaaaga   2220

aaaatgttta ttgtcctgct aatctatatg cctacacctc agaagctgac agatgagctt   2280

cctaaaacat gaggatgaat aaatgttaga actgtgatat cttctcattt ccacagagat   2340

ttgggtttaa aacaaatggc taatatttgt aagcctgaaa gctgccatcc tctttaacat   2400

cctacctacc ttttaaaata ttttctggag gttaagtaca gttaggcact agaacatttg   2460

ttaagcctcc caaagtagtg tgcatggaag attctagagt gtccagctct tgcactacaa   2520

atgtaataat aacagaataa atacacttac cctgatgata ttgagggtac atgattagcc   2580

taatgtgatg tcatatgagg aagtttagga gtccattttt caggtggttt ggtgatagga   2640

ataaaaatgt tactcccgtc gctgatttgg aagaaaaccg atgaagtaca agtaaggttt   2700

ccccactcct gtgtgtggtc atgggaagcc attagaggga agctgcagaa cagaatggaa   2760

caggacaggc tgggctagac tcgagcacgc agtggcccct gtgccaccac actgtgggtc   2820

aggaacacgc gtcatggtgt tcttgtcgga atgtgaacat acagcaccct ctagcattac   2880

gaatctctta ggatttttaa gattgtattt gataatactt atatttcaca gggcacactt   2940

ttggcacacc tcagagcaca ctgctgctat tttgggtcgt atcactgtaa aatacataat   3000

aagtactact taactgtgac atgaagaatt ggaatcccag agggcaacat ttgatttgac   3060

taagatcagg cataagatag aatttttgtc atttttcctt gcagttttat tgacttagtt   3120

tatgagcttg gataaaataa ttttttgatg aatcatgtca ataaaaggaa aaataatgta   3180

actacctcat aagtctgata aaaggaagtt gctagtgttt tatagaattt ctgaaggtgg   3240

ttaaatcaag tatgatttca aaatatcaac tagttccact tttgtgattg caggatgctt   3300

cttatactaa agttctcata aataataaat cagcttatgc caaaaata                3348


<210>  1254
<211>  443
<212>  PRT
<213>  Homosapiens

<400>  1254

Met Glu Cys Leu Arg Ser Leu Pro Cys Leu Leu Pro Arg Ala Met Arg 
1               5                   10                  15      


Leu Pro Arg Arg Thr Leu Cys Ala Leu Ala Leu Asp Val Thr Ser Val 
            20                  25                  30          


Gly Pro Pro Val Ala Ala Cys Gly Arg Arg Ala Asn Leu Ile Gly Arg 
        35                  40                  45              


Ser Arg Ala Ala Gln Leu Cys Gly Pro Asp Arg Leu Arg Val Ala Gly 
    50                  55                  60                  


Glu Val His Arg Phe Arg Thr Ser Asp Val Ser Gln Ala Thr Leu Ala 
65                  70                  75                  80  


Ser Val Ala Pro Val Phe Thr Val Thr Lys Phe Asp Lys Gln Gly Asn 
                85                  90                  95      


Val Thr Ser Phe Glu Arg Lys Lys Thr Glu Leu Tyr Gln Glu Leu Gly 
            100                 105                 110         


Leu Gln Ala Arg Asp Leu Arg Phe Gln His Val Met Ser Ile Thr Val 
        115                 120                 125             


Arg Asn Asn Arg Ile Ile Met Arg Met Glu Tyr Leu Lys Ala Val Ile 
    130                 135                 140                 


Thr Pro Glu Cys Leu Leu Ile Leu Asp Tyr Arg Asn Leu Asn Leu Glu 
145                 150                 155                 160 


Gln Trp Leu Phe Arg Glu Leu Pro Ser Gln Leu Ser Gly Glu Gly Gln 
                165                 170                 175     


Leu Val Thr Tyr Pro Leu Pro Phe Glu Phe Arg Ala Ile Glu Ala Leu 
            180                 185                 190         


Leu Gln Tyr Trp Ile Asn Thr Leu Gln Gly Lys Leu Ser Ile Leu Gln 
        195                 200                 205             


Pro Leu Ile Leu Glu Thr Leu Asp Ala Leu Val Asp Pro Lys His Ser 
    210                 215                 220                 


Ser Val Asp Arg Ser Lys Leu His Ile Leu Leu Gln Asn Gly Lys Ser 
225                 230                 235                 240 


Leu Ser Glu Leu Glu Thr Asp Ile Lys Ile Phe Lys Glu Ser Ile Leu 
                245                 250                 255     


Glu Ile Leu Asp Glu Glu Glu Leu Leu Glu Glu Leu Cys Val Ser Lys 
            260                 265                 270         


Trp Ser Asp Pro Gln Val Phe Glu Lys Ser Ser Ala Gly Ile Asp His 
        275                 280                 285             


Ala Glu Glu Met Glu Leu Leu Leu Glu Asn Tyr Tyr Arg Leu Ala Asp 
    290                 295                 300                 


Asp Leu Ser Asn Ala Ala Arg Glu Leu Arg Val Leu Ile Asp Asp Ser 
305                 310                 315                 320 


Gln Ser Ile Ile Phe Ile Asn Leu Asp Ser His Arg Asn Val Met Met 
                325                 330                 335     


Arg Leu Asn Leu Gln Leu Thr Met Gly Thr Phe Ser Leu Ser Leu Phe 
            340                 345                 350         


Gly Leu Met Gly Val Ala Phe Gly Met Asn Leu Glu Ser Ser Leu Glu 
        355                 360                 365             


Glu Asp His Arg Ile Phe Trp Leu Ile Thr Gly Ile Met Phe Met Gly 
    370                 375                 380                 


Ser Gly Leu Ile Trp Arg Arg Leu Leu Ser Phe Leu Gly Arg Gln Leu 
385                 390                 395                 400 


Glu Ala Pro Leu Pro Pro Met Met Ala Ser Leu Pro Lys Lys Thr Leu 
                405                 410                 415     


Leu Ala Asp Arg Ser Met Glu Leu Lys Asn Ser Leu Arg Leu Asp Gly 
            420                 425                 430         


Leu Gly Ser Gly Arg Ser Ile Leu Thr Asn Arg 
        435                 440             


<210>  1255
<211>  3489
<212>  DNA
<213>  Homosapiens

<400>  1255
gtgacctgct tagagagaag cggtgggtct gcacctggat tttggagtcc cagtgctgct     60

gcagctctga gcattcccac gtcaccagag aagccggtgg gcaatgagat catgtctgct    120

ttcaggttgt ggcctggcct gctgatcatg ttgggttctc tctgccatag aggttcaccg    180

tgtggccttt caacacacgt agaaatagga cacagagctc tggagtttct tcagcttcac    240

aatgggcgtg ttaactacag agagctgtta ctagaacacc aggatgcgta tcaggctgga    300

atcgtgtttc ctgattgttt ttaccctagc atctgcaaag gaggaaaatt ccatgatgtg    360

tctgagagca ctcactggac tccgtttctt aatgcaagcg ttcattatat ccgagagaac    420

tatccccttc cctgggagaa ggacacagag aaactggtag ctttcttgtt tggaattact    480

tctcacatgg cggcagatgt cagctggcat agtctgggcc ttgaacaagg attccttagg    540

accatgggag ctattgattt tcacggctcc tattcagagg ctcattcggc tggtgatttt    600

ggaggagatg tgttgagcca gtttgaattt aattttaatt accttgcacg acgctggtat    660

gtgccagtca aagatctact gggaatttat gagaaactgt atggtcgaaa agtcatcacc    720

gaaaatgtaa tcgttgattg ttcacatatc cagttcttag aaatgtatgg tgagatgcta    780

gctgtttcca agttatatcc cacttactct acaaagtccc cgtttttggt ggaacaattc    840

caagagtatt ttcttggagg actggatgat atggcatttt ggtccactaa tatttaccat    900

ctaacaagct tcatgttgga gaatgggacc agtgactgca acctgcctga gaaccctctg    960

ttcattgcat gtggcggcca gcaaaaccac acccagggct caaaaatgca gaaaaatgat   1020

tttcacagaa atttgactac atccctaact gaaagtgttg acaggaatat aaactatact   1080

gaaagaggag tgttctttag tgtaaattcc tggaccccgg attccatgtc ctttatctac   1140

aaggctttgg aaaggaacat aaggacaatg ttcataggtg gctctcagtt gtcacaaaag   1200

cacgtctcca gccccttagc atcttacttc ttgtcatttc cttatgcgag gcttggctgg   1260

gcaatgacct cagctgacct caaccaggat gggcacggtg acctcgtggt gggcgcacca   1320

ggctacagcc gccccggcca catccacatc gggcgcgtgt acctcatcta cggcaatgac   1380

ctgggcctgc cacctgttga cctggacctg gacaaggagg cccacaggat ccttgaaggc   1440

ttccagccct caggtcggtt tggctcggcc ttggctgtgt tggactttaa cgtggacggc   1500

gtgcctgacc tggccgtggg agctccctcg gtgggctccg agcagctcac ctacaaaggt   1560

gccgtgtatg tctactttgg ttccaaacaa ggaggaatgt cttcttcccc taacatcacc   1620

atttcttgcc aggacatcta ctgtaacttg ggctggactc tcttggctgc agatgtgaat   1680

ggagacagtg aacccgatct ggtcatcggc tccccttttg caccaggtgg agggaagcag   1740

aagggaattg tggctgcgtt ttattctggc cccagcctga gcgacaaaga aaaactgaac   1800

gtggaggcag ccaactggac ggtgagaggc gaggaagact tctcctggtt tggatattcc   1860

cttcacggtg tcactgtgga caacagaacc ttgctgttgg ttgggagccc gacctggaag   1920

aatgccagca ggctgggcca tttgttacac atccgagatg agaaaaagag ccttgggagg   1980

gtgtatggct acttcccacc aaacggccaa agctggttta ccatttctgg agacaaggca   2040

atggggaaac tgggtacttc cctttccagt ggccacgtac tgatgaatgg gactctgaaa   2100

caagtgctgc tggttggagc ccctacgtac gatgacgtgt ctaaggtggc attcctgacc   2160

gtgaccctac accaaggcgg agccactcgc atgtacgcac tcacatctga cgcgcagcct   2220

ctgctgctca gcaccttcag cggagaccgc cgcttctccc gatttggtgg cgttctgcac   2280

ttgagtgacc tggatgatga tggcttagat gaaatcatca tggcagcccc cctgaggata   2340

gcagatgtaa cctctggact gattggggga gaagacggcc gagtatatgt atataatggc   2400

aaagagacca cccttggtga catgactggc aaatgcaaat catggataac tccatgtcca   2460

gaagaaaagg cccaatatgt attgatttct cctgaagcca gctcaaggtt tgggagctcc   2520

ctcatcaccg tgaggtccaa ggcaaagaac caagtcgtca ttgctgctgg aaggagttct   2580

ttgggagccc gactctccgg ggcacttcac gtctatagcc ttggctcaga ttgaagattt   2640

cactgcattt ccccactctg cccacctctc tcatgctgaa tcacatccat ggtgagcatt   2700

ttgatggaca aagtggcaca tccagtggag cggtggtaga tcctgataga catggggctc   2760

ctgggagtag agagacacac taacagccac accctctgga aatctgatac agtaaatata   2820

tgactgcacc agaaatatgt gaaatagcag acattctgct tactcatgtc tccttccaca   2880

gtttacttcc tcgctccctt tgcatctaaa cctttcttct ttcccaactt attgcctgta   2940

gtcagacctg ctgtacaacc tatttcctct tcctcttgaa tgtctttcca atggctggaa   3000

aggtccctct gtggttatct gttagaacag tctctgtaca caattcctcc taaaaacatc   3060

cttttttaaa aaaagaattg ttcagccata aagaaagaac aagatcatgc cctttgcagg   3120

gacatggatg gagctggagg ccattatcct tcataaacta ttgcaggaac agaaaaccaa   3180

acactccata ttctcacttg taagtgggag ctaaatgaga acacgtggac acatagaggg   3240

aaacaacaca cactggggcc tatgagaggg cggaaggtgg gaggagggag agatcaggaa   3300

aaataactaa tggatactta gggtgatgaa ataatctgtg taacaaaccc ccatgacaca   3360

cctttatgta tgtaacaaac cagcacttcc tgcgcatgta cccctgaact taaaagttaa   3420

aaaaaagttg aacttaaaaa taacagattg gcccatgcca atcaaagtat aatagaaagc   3480

atagtatac                                                           3489


<210>  1256
<211>  840
<212>  PRT
<213>  Homosapiens

<400>  1256

Met Ser Ala Phe Arg Leu Trp Pro Gly Leu Leu Ile Met Leu Gly Ser 
1               5                   10                  15      


Leu Cys His Arg Gly Ser Pro Cys Gly Leu Ser Thr His Val Glu Ile 
            20                  25                  30          


Gly His Arg Ala Leu Glu Phe Leu Gln Leu His Asn Gly Arg Val Asn 
        35                  40                  45              


Tyr Arg Glu Leu Leu Leu Glu His Gln Asp Ala Tyr Gln Ala Gly Ile 
    50                  55                  60                  


Val Phe Pro Asp Cys Phe Tyr Pro Ser Ile Cys Lys Gly Gly Lys Phe 
65                  70                  75                  80  


His Asp Val Ser Glu Ser Thr His Trp Thr Pro Phe Leu Asn Ala Ser 
                85                  90                  95      


Val His Tyr Ile Arg Glu Asn Tyr Pro Leu Pro Trp Glu Lys Asp Thr 
            100                 105                 110         


Glu Lys Leu Val Ala Phe Leu Phe Gly Ile Thr Ser His Met Ala Ala 
        115                 120                 125             


Asp Val Ser Trp His Ser Leu Gly Leu Glu Gln Gly Phe Leu Arg Thr 
    130                 135                 140                 


Met Gly Ala Ile Asp Phe His Gly Ser Tyr Ser Glu Ala His Ser Ala 
145                 150                 155                 160 


Gly Asp Phe Gly Gly Asp Val Leu Ser Gln Phe Glu Phe Asn Phe Asn 
                165                 170                 175     


Tyr Leu Ala Arg Arg Trp Tyr Val Pro Val Lys Asp Leu Leu Gly Ile 
            180                 185                 190         


Tyr Glu Lys Leu Tyr Gly Arg Lys Val Ile Thr Glu Asn Val Ile Val 
        195                 200                 205             


Asp Cys Ser His Ile Gln Phe Leu Glu Met Tyr Gly Glu Met Leu Ala 
    210                 215                 220                 


Val Ser Lys Leu Tyr Pro Thr Tyr Ser Thr Lys Ser Pro Phe Leu Val 
225                 230                 235                 240 


Glu Gln Phe Gln Glu Tyr Phe Leu Gly Gly Leu Asp Asp Met Ala Phe 
                245                 250                 255     


Trp Ser Thr Asn Ile Tyr His Leu Thr Ser Phe Met Leu Glu Asn Gly 
            260                 265                 270         


Thr Ser Asp Cys Asn Leu Pro Glu Asn Pro Leu Phe Ile Ala Cys Gly 
        275                 280                 285             


Gly Gln Gln Asn His Thr Gln Gly Ser Lys Met Gln Lys Asn Asp Phe 
    290                 295                 300                 


His Arg Asn Leu Thr Thr Ser Leu Thr Glu Ser Val Asp Arg Asn Ile 
305                 310                 315                 320 


Asn Tyr Thr Glu Arg Gly Val Phe Phe Ser Val Asn Ser Trp Thr Pro 
                325                 330                 335     


Asp Ser Met Ser Phe Ile Tyr Lys Ala Leu Glu Arg Asn Ile Arg Thr 
            340                 345                 350         


Met Phe Ile Gly Gly Ser Gln Leu Ser Gln Lys His Val Ser Ser Pro 
        355                 360                 365             


Leu Ala Ser Tyr Phe Leu Ser Phe Pro Tyr Ala Arg Leu Gly Trp Ala 
    370                 375                 380                 


Met Thr Ser Ala Asp Leu Asn Gln Asp Gly His Gly Asp Leu Val Val 
385                 390                 395                 400 


Gly Ala Pro Gly Tyr Ser Arg Pro Gly His Ile His Ile Gly Arg Val 
                405                 410                 415     


Tyr Leu Ile Tyr Gly Asn Asp Leu Gly Leu Pro Pro Val Asp Leu Asp 
            420                 425                 430         


Leu Asp Lys Glu Ala His Arg Ile Leu Glu Gly Phe Gln Pro Ser Gly 
        435                 440                 445             


Arg Phe Gly Ser Ala Leu Ala Val Leu Asp Phe Asn Val Asp Gly Val 
    450                 455                 460                 


Pro Asp Leu Ala Val Gly Ala Pro Ser Val Gly Ser Glu Gln Leu Thr 
465                 470                 475                 480 


Tyr Lys Gly Ala Val Tyr Val Tyr Phe Gly Ser Lys Gln Gly Gly Met 
                485                 490                 495     


Ser Ser Ser Pro Asn Ile Thr Ile Ser Cys Gln Asp Ile Tyr Cys Asn 
            500                 505                 510         


Leu Gly Trp Thr Leu Leu Ala Ala Asp Val Asn Gly Asp Ser Glu Pro 
        515                 520                 525             


Asp Leu Val Ile Gly Ser Pro Phe Ala Pro Gly Gly Gly Lys Gln Lys 
    530                 535                 540                 


Gly Ile Val Ala Ala Phe Tyr Ser Gly Pro Ser Leu Ser Asp Lys Glu 
545                 550                 555                 560 


Lys Leu Asn Val Glu Ala Ala Asn Trp Thr Val Arg Gly Glu Glu Asp 
                565                 570                 575     


Phe Ser Trp Phe Gly Tyr Ser Leu His Gly Val Thr Val Asp Asn Arg 
            580                 585                 590         


Thr Leu Leu Leu Val Gly Ser Pro Thr Trp Lys Asn Ala Ser Arg Leu 
        595                 600                 605             


Gly His Leu Leu His Ile Arg Asp Glu Lys Lys Ser Leu Gly Arg Val 
    610                 615                 620                 


Tyr Gly Tyr Phe Pro Pro Asn Gly Gln Ser Trp Phe Thr Ile Ser Gly 
625                 630                 635                 640 


Asp Lys Ala Met Gly Lys Leu Gly Thr Ser Leu Ser Ser Gly His Val 
                645                 650                 655     


Leu Met Asn Gly Thr Leu Lys Gln Val Leu Leu Val Gly Ala Pro Thr 
            660                 665                 670         


Tyr Asp Asp Val Ser Lys Val Ala Phe Leu Thr Val Thr Leu His Gln 
        675                 680                 685             


Gly Gly Ala Thr Arg Met Tyr Ala Leu Thr Ser Asp Ala Gln Pro Leu 
    690                 695                 700                 


Leu Leu Ser Thr Phe Ser Gly Asp Arg Arg Phe Ser Arg Phe Gly Gly 
705                 710                 715                 720 


Val Leu His Leu Ser Asp Leu Asp Asp Asp Gly Leu Asp Glu Ile Ile 
                725                 730                 735     


Met Ala Ala Pro Leu Arg Ile Ala Asp Val Thr Ser Gly Leu Ile Gly 
            740                 745                 750         


Gly Glu Asp Gly Arg Val Tyr Val Tyr Asn Gly Lys Glu Thr Thr Leu 
        755                 760                 765             


Gly Asp Met Thr Gly Lys Cys Lys Ser Trp Ile Thr Pro Cys Pro Glu 
    770                 775                 780                 


Glu Lys Ala Gln Tyr Val Leu Ile Ser Pro Glu Ala Ser Ser Arg Phe 
785                 790                 795                 800 


Gly Ser Ser Leu Ile Thr Val Arg Ser Lys Ala Lys Asn Gln Val Val 
                805                 810                 815     


Ile Ala Ala Gly Arg Ser Ser Leu Gly Ala Arg Leu Ser Gly Ala Leu 
            820                 825                 830         


His Val Tyr Ser Leu Gly Ser Asp 
        835                 840 


<210>  1257
<211>  1096
<212>  DNA
<213>  Homosapiens

<400>  1257
agtgctgctg cagctctgag cattcccacg tcaccagaga agccggtggg caatgagatc     60

atgtctgctt tcaggttgtg gcctggcctg ctgatcatgt tgggttctct ctgccataga    120

ggttcaccgt gtggcctttc aacacacgta gaaataggac acagagctct ggagtttctt    180

cagcttcaca atgggcgtgt taactacaga gagctgttac tagaacacca ggatgcgtat    240

caggctggaa tcgtgtttcc tgattgtttt taccctagca tctgcaaagg aggaaaattc    300

catgatgtgt ctgagagcac tcactggact ccgtttctta atgcaagcgt tcattatatc    360

cgagagaact atccccttcc ctgggagaag gacacagaga aactggtagc tttcttgttt    420

ggaattactt ctcacatggc ggcagatgtc agctggcata gtctgggcct tgaacaagga    480

ttccttagga ccatgggagc tattgatttt cacggctcct attcagaggc tcattcggct    540

ggtgattttg gtactgttta tttacatttg ctaaattttc tcgtggtata gttcacttat    600

aatgacatca ctactgtgct ttaaatatgt gtgtctttaa tattttgctg gttgcatgta    660

ttttctattt aatgttgcag ttcatttaga gtagagatgt acctcattta acatagagat    720

gtatttctaa aaacttgtgt ctatatgtat ttttttgtta aaaaattcta cactttgttg    780

ttgacatgtc ataattttag aaaaacttta cttatacatt gggttaaaat tcattagcta    840

gtgtctccta ctttcctaat actttagctt taaactagta aactccacct tttgcctgta    900

gtagtaaatt gcttttaaat atttaaacta ggtggtgaat ggtgtttatt aaacccttat    960

ggtcgatatt tccttaaagt aaaacaaaaa acacctttgg ttatatggcc agttctttct   1020

taatttatat gtttcactaa ctaagatttt taaaagataa ttttttctta aaaaaaaaaa   1080

aaaaaaaaaa aaaaaa                                                   1096


<210>  1258
<211>  176
<212>  PRT
<213>  Homosapiens

<400>  1258

Met Ser Ala Phe Arg Leu Trp Pro Gly Leu Leu Ile Met Leu Gly Ser 
1               5                   10                  15      


Leu Cys His Arg Gly Ser Pro Cys Gly Leu Ser Thr His Val Glu Ile 
            20                  25                  30          


Gly His Arg Ala Leu Glu Phe Leu Gln Leu His Asn Gly Arg Val Asn 
        35                  40                  45              


Tyr Arg Glu Leu Leu Leu Glu His Gln Asp Ala Tyr Gln Ala Gly Ile 
    50                  55                  60                  


Val Phe Pro Asp Cys Phe Tyr Pro Ser Ile Cys Lys Gly Gly Lys Phe 
65                  70                  75                  80  


His Asp Val Ser Glu Ser Thr His Trp Thr Pro Phe Leu Asn Ala Ser 
                85                  90                  95      


Val His Tyr Ile Arg Glu Asn Tyr Pro Leu Pro Trp Glu Lys Asp Thr 
            100                 105                 110         


Glu Lys Leu Val Ala Phe Leu Phe Gly Ile Thr Ser His Met Ala Ala 
        115                 120                 125             


Asp Val Ser Trp His Ser Leu Gly Leu Glu Gln Gly Phe Leu Arg Thr 
    130                 135                 140                 


Met Gly Ala Ile Asp Phe His Gly Ser Tyr Ser Glu Ala His Ser Ala 
145                 150                 155                 160 


Gly Asp Phe Gly Thr Val Tyr Leu His Leu Leu Asn Phe Leu Val Val 
                165                 170                 175     


<210>  1259
<211>  5131
<212>  DNA
<213>  Homosapiens

<400>  1259
gtttcctgtc gccgtcgttg cccgggccat ggcgacctgc atttggctgc ggagctgtgg     60

ggcccggcgc ctcgggtcga cgtttccagg ctgccgcctc cgcccccgcg ccggcggcct    120

ggtccctgcc tccgggcctg cgcccggccc ggcccagctc cgctgctacg ctgggcgcct    180

ggcgggcctc tctgcggcgc tgctgcgcac cgacagcttc gtgggcggcc gctggctccc    240

ggccgccgcc accttccccg tgcaagaccc ggccagcggc gccgctctgg gcatggtagc    300

cgactgcggg gtgcgagagg cccgcgccgc cgtgcgcgct gcctacgagg ctttctgccg    360

ctggagggag gtctccgcca aggagaggag ttcattactt cggaagtggt acaatttaat    420

gatacaaaat aaggatgacc ttgccagaat aatcacagct gaaagtggaa agccactgaa    480

ggaggcacat ggagaaattc tctattccgc ctttttccta gagtggttct ctgaggaagc    540

ccgccgtgtt tacggagaca ttatccacac cccggcaaag gacaggcggg ccctggtcct    600

caagcagccc ataggcgtgg ctgcagtcat caccccgtgg aatttcccca gtgccatgat    660

cacccggaag gtgggggccg ccctggcagc cggctgtact gtcgtggtga agcctgccga    720

agacacgccc ttctccgccc tggccctggc tgagcttgca agccaggctg ggattccttc    780

aggtgtatac aatgttattc cctgttctcg aaagaatgcc aaggaagtag gggaggcaat    840

ttgtactgat cctctggtgt ccaaaatttc ctttactggt tcaacaacta caggaaagat    900

cctgttgcac cacgcagcaa actctgtgaa aagggtctct atggagctgg gcggccttgc    960

tccatttata gtatttgaca gtgccaacgt ggaccaggct gtagcagggg ccatggcatc   1020

taaatttagg aacactggac agacttgtgt ttgctcaaac caattcttgg tgcaaagggg   1080

catccatgat gcctttgtaa aagcattcgc cgaggccatg aagaagaacc tgcgcgtagg   1140

taatggattt gaggaaggaa ctactcaggg cccattaatt aatgaaaaag cggtagaaaa   1200

ggtggagaaa caggtgaatg atgccgtttc taaaggtgcc accgttgtga caggtggaaa   1260

acgacaccaa cttggaaaaa atttctttga gcctaccctg ctgtgcaatg tcacccagga   1320

catgctgtgc actcatgaag agactttcgg gcctctggca ccagttatca agttcgatac   1380

agaggaggag gctatagcaa tcgctaacgc agctgatgtt gggttagcag gttattttta   1440

ctctcaagac ccagcccaga tctggagagt ggcagagcag ctggaagtgg gcatggttgg   1500

cgtcaacgaa ggattaattt cctctgtgga gtgccctttt ggtggagtga agcagtccgg   1560

ccttgggcga gaggggtcca agtatggcat tgatgagtat ctggaactca agtatgtgtg   1620

ttacgggggc ttgtaggatt ctttggttct ttaaaaaaat ttaaaaggag acttatctac   1680

atatataggt acatgccatc cattatttta aataaactaa taggttttca gaattatgaa   1740

tttttcagaa ctcatccagt ccttgtaatc ttaaacagat gcaaatccta cccctgccct   1800

taatgtaact agggaccaat atgtgccacg tgcctgtggc tgcagactcc cagagaacca   1860

gcactgggtt tacagaatga ggccctggct ccccaccaca gccccagctg cctcagagca   1920

ggcacagcac aaggcaggcc cagccccatg ggccgtcaca aaggcttgat cactgcctgg   1980

gcagtggcac aaccatcccc catgtcgcta cagaacatgg gcccagagca ccttgaagga   2040

gacccttgac tgtgactggc aggcaggtga ggggcacagc acccctcccc ggcatctgcc   2100

agctcagcac agaagacacc gaatgtgcat ctggaggtgt tgcggcagag gtttgagtga   2160

accctctttc aaagacaata aatagcacag aattgtccgt gcttctgtga ggcacgaagg   2220

agcacctctc cctattcctg aaccatattt taattgatgc ctttattgtc ccaaatttac   2280

cacttaaaga attctatttt catttctgtc ctgtttgcca cttcatttca tttccttgag   2340

taaatgagct gaagtgtaaa gcaaagaata gcagaagcag cttggtagga tggaaggcac   2400

gcagtggcat ggcctggctc cttccctgag tggccttgtt gccttgggcg tgtgttcagc   2460

acctcccatc ccatggatac agtggagatt ccatacaggc cttacttagc tccttgcgat   2520

actgtgagcc agagagaaag taaaagcact tcacaaaaaa atgaaaattc taaggacata   2580

caagagccat tgttacgagc agcaccgccc agcccttcct tgcctactgt cagtggcttt   2640

gccaagatgg gaggaggcca gtgcccactt gcccaccgac ctgagcctga gtaagtggct   2700

gtcacctgag cctgttcttt ctgtcctggt gtggtgctgc tccctcacct ccaaaagagc   2760

aaaagtactt tcaccacagt caacccaaaa gggaaagaat ttctgtaatt gccaacccac   2820

tttgtagaag aggcatgagc ccttgaattt caggcacctt ttatctaatg agagttttta   2880

cagctcatca ttcaaataac gcacaaaaaa caaaagccgc tatgaccggc gttgcctctc   2940

actttgaaag aaagactccg taatcttaaa cagatgcaaa tccaattagg cggccaagta   3000

ggtggagacg aagcaccttc ctttccccat ctctgtctgt gtagactcca cttacatctt   3060

gtggttattc tgggttgtgg aaggaaaatg tgaatgaaag tagtgctgga tgcaattact   3120

cctgaacccc acctaggatt taacatccct cattgagcca ctgggaagct atggttgagt   3180

aactaaaggt ctggcaagac cctgggcaca cagggagctg cctagcatct ggcctggagt   3240

gtactagcca cattcccaag gtcccaagga gaaggaagag ctgaaattca tctcctagtg   3300

acagtgcccc ggccctgtca agaatcacat actcagcatt ttgacagtta atgtcttctc   3360

tttatttgtg tagtttttag gtggttttat ataacatttt aattacttgt gatttagatg   3420

tatccatcct ttttctatta agaatacaaa tgctgggctg ggcacagtgg ctcacgcctg   3480

taatcccaac accttgggag gccaaggcag gcagatcacg acatcaggag atcgagacca   3540

tcctggctaa cacggtgaaa ccccgtctct actaaaaata caaaaaaaat tagtcggatg   3600

tggtggcagg tgcctgtagt cccagctact ctggaggctg aggcaggaga atggcgtgaa   3660

cccaggaggc ggagcttgca gtgagcagag atcacgccac tgcactccag cctggatgac   3720

agagcgagac tccgcctcaa aaaaagaata caaatgctcc aacattattt tttataactc   3780

tggattaccg atgctgagat gtgtgcagga atacttccaa ataaattttt aacattgtaa   3840

gccagtagat tctttggctg ggtggcaaat tttgagtctt cttgcatatt tggctcatgg   3900

gttcataaat tgaggccaga gactcattgt atatccttga tcaattttct aattaaagga   3960

aatagcttat tgtttagtaa aatggccctt ggttgtggga agaaagagaa ttatttttaa   4020

ctgaacgttt ttgttgtttt ttaaataaag tagccatatg taacgggatt ttaaaaatat   4080

atacatttta caacatggac tagaaaagga ccattagatc aggggttggc aaactatggc   4140

ccacgaatca aacctggcct gccacctgtt tttatacaac ctgtgagcta agaatggttt   4200

atatgttttc aaatgattgg gcagaaaatc aaaagaagaa caatatttca tgacacctga   4260

aaattctatg aaattcagat ttcagtgtcc ataaacaaaa tgttattaga gcatagccac   4320

acccattcat ttatggtatt gtctgggact gctttcttgg cagagttgaa tagttgggac   4380

agggacagta tagcctgcaa agcctaaaag atttactact tgtctcctta aagaaaaagt   4440

ttgccagctc ctgatctaga ccaagaggga gatattgacc ttacttgcat ttatccggca   4500

ttatttcaac acctcctgtg aagaaagtac ttttctggca tagctaccgt gagttctcag   4560

caggaacttc ccagcgatga taatgtacat gaaattagcc acgtaacaag agtctatttg   4620

ccttgaaaaa acaattatcc ttgaacttcc tccagctatg cagggattct cattaaagag   4680

ctgatctgca tctgtttatc cattttagta gcttttaaat atgattttat gtgaagtgcc   4740

atttctttat tctactaaag agagacagca gaaataaaga tcagaagcaa atgtgagcaa   4800

atctgtttta ctgttaactt caattatgaa cttgaaattg tgccacatga ctttttcctc   4860

taaaaactgg atcctagtgt tttaattacc tgtgtgcagc tattttaaat agcattttac   4920

ttgaataata tgtatgttgt cattgtttca tgctatactt tgtgggataa aacttgggaa   4980

tgagtgtggt aagaaattta taaagttttg cttttaaaac gtggacataa ctcatttttc   5040

tagtttttga caattgtgtg ttttagtgtc tagtctgcag agagctgtgt gattaataaa   5100

cgtggaatta acagaatttc ctctccctgt a                                  5131


<210>  1260
<211>  535
<212>  PRT
<213>  Homosapiens

<400>  1260

Met Ala Thr Cys Ile Trp Leu Arg Ser Cys Gly Ala Arg Arg Leu Gly 
1               5                   10                  15      


Ser Thr Phe Pro Gly Cys Arg Leu Arg Pro Arg Ala Gly Gly Leu Val 
            20                  25                  30          


Pro Ala Ser Gly Pro Ala Pro Gly Pro Ala Gln Leu Arg Cys Tyr Ala 
        35                  40                  45              


Gly Arg Leu Ala Gly Leu Ser Ala Ala Leu Leu Arg Thr Asp Ser Phe 
    50                  55                  60                  


Val Gly Gly Arg Trp Leu Pro Ala Ala Ala Thr Phe Pro Val Gln Asp 
65                  70                  75                  80  


Pro Ala Ser Gly Ala Ala Leu Gly Met Val Ala Asp Cys Gly Val Arg 
                85                  90                  95      


Glu Ala Arg Ala Ala Val Arg Ala Ala Tyr Glu Ala Phe Cys Arg Trp 
            100                 105                 110         


Arg Glu Val Ser Ala Lys Glu Arg Ser Ser Leu Leu Arg Lys Trp Tyr 
        115                 120                 125             


Asn Leu Met Ile Gln Asn Lys Asp Asp Leu Ala Arg Ile Ile Thr Ala 
    130                 135                 140                 


Glu Ser Gly Lys Pro Leu Lys Glu Ala His Gly Glu Ile Leu Tyr Ser 
145                 150                 155                 160 


Ala Phe Phe Leu Glu Trp Phe Ser Glu Glu Ala Arg Arg Val Tyr Gly 
                165                 170                 175     


Asp Ile Ile His Thr Pro Ala Lys Asp Arg Arg Ala Leu Val Leu Lys 
            180                 185                 190         


Gln Pro Ile Gly Val Ala Ala Val Ile Thr Pro Trp Asn Phe Pro Ser 
        195                 200                 205             


Ala Met Ile Thr Arg Lys Val Gly Ala Ala Leu Ala Ala Gly Cys Thr 
    210                 215                 220                 


Val Val Val Lys Pro Ala Glu Asp Thr Pro Phe Ser Ala Leu Ala Leu 
225                 230                 235                 240 


Ala Glu Leu Ala Ser Gln Ala Gly Ile Pro Ser Gly Val Tyr Asn Val 
                245                 250                 255     


Ile Pro Cys Ser Arg Lys Asn Ala Lys Glu Val Gly Glu Ala Ile Cys 
            260                 265                 270         


Thr Asp Pro Leu Val Ser Lys Ile Ser Phe Thr Gly Ser Thr Thr Thr 
        275                 280                 285             


Gly Lys Ile Leu Leu His His Ala Ala Asn Ser Val Lys Arg Val Ser 
    290                 295                 300                 


Met Glu Leu Gly Gly Leu Ala Pro Phe Ile Val Phe Asp Ser Ala Asn 
305                 310                 315                 320 


Val Asp Gln Ala Val Ala Gly Ala Met Ala Ser Lys Phe Arg Asn Thr 
                325                 330                 335     


Gly Gln Thr Cys Val Cys Ser Asn Gln Phe Leu Val Gln Arg Gly Ile 
            340                 345                 350         


His Asp Ala Phe Val Lys Ala Phe Ala Glu Ala Met Lys Lys Asn Leu 
        355                 360                 365             


Arg Val Gly Asn Gly Phe Glu Glu Gly Thr Thr Gln Gly Pro Leu Ile 
    370                 375                 380                 


Asn Glu Lys Ala Val Glu Lys Val Glu Lys Gln Val Asn Asp Ala Val 
385                 390                 395                 400 


Ser Lys Gly Ala Thr Val Val Thr Gly Gly Lys Arg His Gln Leu Gly 
                405                 410                 415     


Lys Asn Phe Phe Glu Pro Thr Leu Leu Cys Asn Val Thr Gln Asp Met 
            420                 425                 430         


Leu Cys Thr His Glu Glu Thr Phe Gly Pro Leu Ala Pro Val Ile Lys 
        435                 440                 445             


Phe Asp Thr Glu Glu Glu Ala Ile Ala Ile Ala Asn Ala Ala Asp Val 
    450                 455                 460                 


Gly Leu Ala Gly Tyr Phe Tyr Ser Gln Asp Pro Ala Gln Ile Trp Arg 
465                 470                 475                 480 


Val Ala Glu Gln Leu Glu Val Gly Met Val Gly Val Asn Glu Gly Leu 
                485                 490                 495     


Ile Ser Ser Val Glu Cys Pro Phe Gly Gly Val Lys Gln Ser Gly Leu 
            500                 505                 510         


Gly Arg Glu Gly Ser Lys Tyr Gly Ile Asp Glu Tyr Leu Glu Leu Lys 
        515                 520                 525             


Tyr Val Cys Tyr Gly Gly Leu 
    530                 535 


<210>  1261
<211>  5170
<212>  DNA
<213>  Homosapiens

<400>  1261
gtttcctgtc gccgtcgttg cccgggccat ggcgacctgc atttggctgc ggagctgtgg     60

ggcccggcgc ctcgggtcga cgtttccagg ctgccgcctc cgcccccgcg ccggcggcct    120

ggtccctgcc tccgggcctg cgcccggccc ggcccagctc cgctgctacg ctgggcgcct    180

ggcgggcctc tctgcggcgc tgctgcgcac cgacagcttc gtgggcggcc gctggctccc    240

ggccgccgcc accttccccg tgcaagaccc ggccagcggc gccgctctgg gcatggtagc    300

cgactgcggg gtgcgagagg cccgcgccgc cgtgcgcgct gcctacgagg ctttctgccg    360

ctggagggag gtctccgcca aggagaggag ttcattactt cggaagtggt acaatttaat    420

gatacaaaat aaggatgacc ttgccagaat aatcacagct gaaagtggaa agccactgaa    480

ggaggcacat ggagaaattc tctattccgc ctttttccta gagtggttct ctgaggaagc    540

ccgccgtgtt tacggagaca ttatccacac cccggcaaag gacaggcggg ccctggtcct    600

caagcagccc ataggcgtgg ctgcagtcat caccccgtgg aatttcccca gtgccatgat    660

cacccggaag gtgggggccg ccctggcagc cggctgtact gtcgtggtga agcctgccga    720

agacacgccc ttctccgccc tggccctggc tgaggtaaat cagggatttc ttcttgattt    780

ggatccattg ttgcttgcaa gccaggctgg gattccttca ggtgtataca atgttattcc    840

ctgttctcga aagaatgcca aggaagtagg ggaggcaatt tgtactgatc ctctggtgtc    900

caaaatttcc tttactggtt caacaactac aggaaagatc ctgttgcacc acgcagcaaa    960

ctctgtgaaa agggtctcta tggagctggg cggccttgct ccatttatag tatttgacag   1020

tgccaacgtg gaccaggctg tagcaggggc catggcatct aaatttagga acactggaca   1080

gacttgtgtt tgctcaaacc aattcttggt gcaaaggggc atccatgatg cctttgtaaa   1140

agcattcgcc gaggccatga agaagaacct gcgcgtaggt aatggatttg aggaaggaac   1200

tactcagggc ccattaatta atgaaaaagc ggtagaaaag gtggagaaac aggtgaatga   1260

tgccgtttct aaaggtgcca ccgttgtgac aggtggaaaa cgacaccaac ttggaaaaaa   1320

tttctttgag cctaccctgc tgtgcaatgt cacccaggac atgctgtgca ctcatgaaga   1380

gactttcggg cctctggcac cagttatcaa gttcgataca gaggaggagg ctatagcaat   1440

cgctaacgca gctgatgttg ggttagcagg ttatttttac tctcaagacc cagcccagat   1500

ctggagagtg gcagagcagc tggaagtggg catggttggc gtcaacgaag gattaatttc   1560

ctctgtggag tgcccttttg gtggagtgaa gcagtccggc cttgggcgag aggggtccaa   1620

gtatggcatt gatgagtatc tggaactcaa gtatgtgtgt tacgggggct tgtaggattc   1680

tttggttctt taaaaaaatt taaaaggaga cttatctaca tatataggta catgccatcc   1740

attattttaa ataaactaat aggttttcag aattatgaat ttttcagaac tcatccagtc   1800

cttgtaatct taaacagatg caaatcctac ccctgccctt aatgtaacta gggaccaata   1860

tgtgccacgt gcctgtggct gcagactccc agagaaccag cactgggttt acagaatgag   1920

gccctggctc cccaccacag ccccagctgc ctcagagcag gcacagcaca aggcaggccc   1980

agccccatgg gccgtcacaa aggcttgatc actgcctggg cagtggcaca accatccccc   2040

atgtcgctac agaacatggg cccagagcac cttgaaggag acccttgact gtgactggca   2100

ggcaggtgag gggcacagca cccctccccg gcatctgcca gctcagcaca gaagacaccg   2160

aatgtgcatc tggaggtgtt gcggcagagg tttgagtgaa ccctctttca aagacaataa   2220

atagcacaga attgtccgtg cttctgtgag gcacgaagga gcacctctcc ctattcctga   2280

accatatttt aattgatgcc tttattgtcc caaatttacc acttaaagaa ttctattttc   2340

atttctgtcc tgtttgccac ttcatttcat ttccttgagt aaatgagctg aagtgtaaag   2400

caaagaatag cagaagcagc ttggtaggat ggaaggcacg cagtggcatg gcctggctcc   2460

ttccctgagt ggccttgttg ccttgggcgt gtgttcagca cctcccatcc catggataca   2520

gtggagattc catacaggcc ttacttagct ccttgcgata ctgtgagcca gagagaaagt   2580

aaaagcactt cacaaaaaaa tgaaaattct aaggacatac aagagccatt gttacgagca   2640

gcaccgccca gcccttcctt gcctactgtc agtggctttg ccaagatggg aggaggccag   2700

tgcccacttg cccaccgacc tgagcctgag taagtggctg tcacctgagc ctgttctttc   2760

tgtcctggtg tggtgctgct ccctcacctc caaaagagca aaagtacttt caccacagtc   2820

aacccaaaag ggaaagaatt tctgtaattg ccaacccact ttgtagaaga ggcatgagcc   2880

cttgaatttc aggcaccttt tatctaatga gagtttttac agctcatcat tcaaataacg   2940

cacaaaaaac aaaagccgct atgaccggcg ttgcctctca ctttgaaaga aagactccgt   3000

aatcttaaac agatgcaaat ccaattaggc ggccaagtag gtggagacga agcaccttcc   3060

tttccccatc tctgtctgtg tagactccac ttacatcttg tggttattct gggttgtgga   3120

aggaaaatgt gaatgaaagt agtgctggat gcaattactc ctgaacccca cctaggattt   3180

aacatccctc attgagccac tgggaagcta tggttgagta actaaaggtc tggcaagacc   3240

ctgggcacac agggagctgc ctagcatctg gcctggagtg tactagccac attcccaagg   3300

tcccaaggag aaggaagagc tgaaattcat ctcctagtga cagtgccccg gccctgtcaa   3360

gaatcacata ctcagcattt tgacagttaa tgtcttctct ttatttgtgt agtttttagg   3420

tggttttata taacatttta attacttgtg atttagatgt atccatcctt tttctattaa   3480

gaatacaaat gctgggctgg gcacagtggc tcacgcctgt aatcccaaca ccttgggagg   3540

ccaaggcagg cagatcacga catcaggaga tcgagaccat cctggctaac acggtgaaac   3600

cccgtctcta ctaaaaatac aaaaaaaatt agtcggatgt ggtggcaggt gcctgtagtc   3660

ccagctactc tggaggctga ggcaggagaa tggcgtgaac ccaggaggcg gagcttgcag   3720

tgagcagaga tcacgccact gcactccagc ctggatgaca gagcgagact ccgcctcaaa   3780

aaaagaatac aaatgctcca acattatttt ttataactct ggattaccga tgctgagatg   3840

tgtgcaggaa tacttccaaa taaattttta acattgtaag ccagtagatt ctttggctgg   3900

gtggcaaatt ttgagtcttc ttgcatattt ggctcatggg ttcataaatt gaggccagag   3960

actcattgta tatccttgat caattttcta attaaaggaa atagcttatt gtttagtaaa   4020

atggcccttg gttgtgggaa gaaagagaat tatttttaac tgaacgtttt tgttgttttt   4080

taaataaagt agccatatgt aacgggattt taaaaatata tacattttac aacatggact   4140

agaaaaggac cattagatca ggggttggca aactatggcc cacgaatcaa acctggcctg   4200

ccacctgttt ttatacaacc tgtgagctaa gaatggttta tatgttttca aatgattggg   4260

cagaaaatca aaagaagaac aatatttcat gacacctgaa aattctatga aattcagatt   4320

tcagtgtcca taaacaaaat gttattagag catagccaca cccattcatt tatggtattg   4380

tctgggactg ctttcttggc agagttgaat agttgggaca gggacagtat agcctgcaaa   4440

gcctaaaaga tttactactt gtctccttaa agaaaaagtt tgccagctcc tgatctagac   4500

caagagggag atattgacct tacttgcatt tatccggcat tatttcaaca cctcctgtga   4560

agaaagtact tttctggcat agctaccgtg agttctcagc aggaacttcc cagcgatgat   4620

aatgtacatg aaattagcca cgtaacaaga gtctatttgc cttgaaaaaa caattatcct   4680

tgaacttcct ccagctatgc agggattctc attaaagagc tgatctgcat ctgtttatcc   4740

attttagtag cttttaaata tgattttatg tgaagtgcca tttctttatt ctactaaaga   4800

gagacagcag aaataaagat cagaagcaaa tgtgagcaaa tctgttttac tgttaacttc   4860

aattatgaac ttgaaattgt gccacatgac tttttcctct aaaaactgga tcctagtgtt   4920

ttaattacct gtgtgcagct attttaaata gcattttact tgaataatat gtatgttgtc   4980

attgtttcat gctatacttt gtgggataaa acttgggaat gagtgtggta agaaatttat   5040

aaagttttgc ttttaaaacg tggacataac tcatttttct agtttttgac aattgtgtgt   5100

tttagtgtct agtctgcaga gagctgtgtg attaataaac gtggaattaa cagaatttcc   5160

tctccctgta                                                          5170


<210>  1262
<211>  548
<212>  PRT
<213>  Homosapiens

<400>  1262

Met Ala Thr Cys Ile Trp Leu Arg Ser Cys Gly Ala Arg Arg Leu Gly 
1               5                   10                  15      


Ser Thr Phe Pro Gly Cys Arg Leu Arg Pro Arg Ala Gly Gly Leu Val 
            20                  25                  30          


Pro Ala Ser Gly Pro Ala Pro Gly Pro Ala Gln Leu Arg Cys Tyr Ala 
        35                  40                  45              


Gly Arg Leu Ala Gly Leu Ser Ala Ala Leu Leu Arg Thr Asp Ser Phe 
    50                  55                  60                  


Val Gly Gly Arg Trp Leu Pro Ala Ala Ala Thr Phe Pro Val Gln Asp 
65                  70                  75                  80  


Pro Ala Ser Gly Ala Ala Leu Gly Met Val Ala Asp Cys Gly Val Arg 
                85                  90                  95      


Glu Ala Arg Ala Ala Val Arg Ala Ala Tyr Glu Ala Phe Cys Arg Trp 
            100                 105                 110         


Arg Glu Val Ser Ala Lys Glu Arg Ser Ser Leu Leu Arg Lys Trp Tyr 
        115                 120                 125             


Asn Leu Met Ile Gln Asn Lys Asp Asp Leu Ala Arg Ile Ile Thr Ala 
    130                 135                 140                 


Glu Ser Gly Lys Pro Leu Lys Glu Ala His Gly Glu Ile Leu Tyr Ser 
145                 150                 155                 160 


Ala Phe Phe Leu Glu Trp Phe Ser Glu Glu Ala Arg Arg Val Tyr Gly 
                165                 170                 175     


Asp Ile Ile His Thr Pro Ala Lys Asp Arg Arg Ala Leu Val Leu Lys 
            180                 185                 190         


Gln Pro Ile Gly Val Ala Ala Val Ile Thr Pro Trp Asn Phe Pro Ser 
        195                 200                 205             


Ala Met Ile Thr Arg Lys Val Gly Ala Ala Leu Ala Ala Gly Cys Thr 
    210                 215                 220                 


Val Val Val Lys Pro Ala Glu Asp Thr Pro Phe Ser Ala Leu Ala Leu 
225                 230                 235                 240 


Ala Glu Val Asn Gln Gly Phe Leu Leu Asp Leu Asp Pro Leu Leu Leu 
                245                 250                 255     


Ala Ser Gln Ala Gly Ile Pro Ser Gly Val Tyr Asn Val Ile Pro Cys 
            260                 265                 270         


Ser Arg Lys Asn Ala Lys Glu Val Gly Glu Ala Ile Cys Thr Asp Pro 
        275                 280                 285             


Leu Val Ser Lys Ile Ser Phe Thr Gly Ser Thr Thr Thr Gly Lys Ile 
    290                 295                 300                 


Leu Leu His His Ala Ala Asn Ser Val Lys Arg Val Ser Met Glu Leu 
305                 310                 315                 320 


Gly Gly Leu Ala Pro Phe Ile Val Phe Asp Ser Ala Asn Val Asp Gln 
                325                 330                 335     


Ala Val Ala Gly Ala Met Ala Ser Lys Phe Arg Asn Thr Gly Gln Thr 
            340                 345                 350         


Cys Val Cys Ser Asn Gln Phe Leu Val Gln Arg Gly Ile His Asp Ala 
        355                 360                 365             


Phe Val Lys Ala Phe Ala Glu Ala Met Lys Lys Asn Leu Arg Val Gly 
    370                 375                 380                 


Asn Gly Phe Glu Glu Gly Thr Thr Gln Gly Pro Leu Ile Asn Glu Lys 
385                 390                 395                 400 


Ala Val Glu Lys Val Glu Lys Gln Val Asn Asp Ala Val Ser Lys Gly 
                405                 410                 415     


Ala Thr Val Val Thr Gly Gly Lys Arg His Gln Leu Gly Lys Asn Phe 
            420                 425                 430         


Phe Glu Pro Thr Leu Leu Cys Asn Val Thr Gln Asp Met Leu Cys Thr 
        435                 440                 445             


His Glu Glu Thr Phe Gly Pro Leu Ala Pro Val Ile Lys Phe Asp Thr 
    450                 455                 460                 


Glu Glu Glu Ala Ile Ala Ile Ala Asn Ala Ala Asp Val Gly Leu Ala 
465                 470                 475                 480 


Gly Tyr Phe Tyr Ser Gln Asp Pro Ala Gln Ile Trp Arg Val Ala Glu 
                485                 490                 495     


Gln Leu Glu Val Gly Met Val Gly Val Asn Glu Gly Leu Ile Ser Ser 
            500                 505                 510         


Val Glu Cys Pro Phe Gly Gly Val Lys Gln Ser Gly Leu Gly Arg Glu 
        515                 520                 525             


Gly Ser Lys Tyr Gly Ile Asp Glu Tyr Leu Glu Leu Lys Tyr Val Cys 
    530                 535                 540                 


Tyr Gly Gly Leu 
545             


<210>  1263
<211>  6801
<212>  DNA
<213>  Homosapiens

<400>  1263
gctgccgcgg gcggtgggcg gggatccccc gggggtgcaa ccttgctcca cctgtgctgc     60

cctcggcggg cctggctggc cccgcgcaga gcggcggcgg cgctcgctgt cactgccgga    120

ggtgagagcg cagcagtagc ttcagcctgt cttgggcttg gtccagattc gctcctctgg    180

ggctacgtcc cggggaagag gaagcgagga ttttgctggg gtggggctgt acctcttaac    240

agcaggtgcg cgcgcgaggg tgtgaacgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg    300

tgtgtgtgtg taagacctgc gatgacgacg aggaggaaca agtgggacgg cgagtgatgc    360

tcagggccag cagcaacgca tggggcgagc ttcagtgtcg ccagcagtga ccacagttct    420

tgaggccaaa tctggctcct aaaaaacatc aaaggaagct tgcaccaaac tctcttcagg    480

gccgcctcag aagcctgcca tcacccactg tgtggtgcac aatggcgccc cccacaggtg    540

tgctctcttc attgctgctg ctggtgacaa ttgcaggttg tgcccgtaag cagtgcagcg    600

aggggaggac atattccaat gcagtcattt cacctaactt ggaaaccacc agaatcatgc    660

gggtgtctca caccttccct gtcgtagact gcacggccgc ttgctgtgac ctgtccagct    720

gtgacctggc ctggtggttc gagggccgct gctacctggt gagctgcccc cacaaagaga    780

actgtgagcc caagaagatg ggccccatca ggtcttatct cacttttgtg ctccggcctg    840

ttcagaggcc tgcacagctg ctggactatg gggacatgat gctgaacagg ggctccccct    900

cggggatctg gggggactca cctgaggata tcagaaagga cttgcccttt ctaggcaaag    960

attggggcct agaggagatg tctgagtacg cagatgacta ccgggagctg gagaaggacc   1020

tcttgcaacc cagtggcaag caggagccca gagggagtgc cgagtacacg gactggggcc   1080

tactgccggg cagcgagggg gccttcaact cctctgttgg agacagtcct gcggtgccag   1140

cggagacgca gcaggaccct gagctccatt acctgaatga gtcggcttca acccctgccc   1200

caaaactccc tgagagaagt gtgttgcttc ccttgccgac tactccatct tcaggagagg   1260

tgttggagaa agaaaaggct tctcagctcc aggaacaatc cagcaacagc tctggaaaag   1320

aggttctaat gccttcccat agtcttcctc cggcaagcct ggagctcagc tcagtcaccg   1380

tggagaaaag cccagtgctc acagtcaccc cggggagtac agagcacagc atcccaacac   1440

ctcccactag cgcagccccc tctgagtcca ccccatctga gctacccata tctcctacca   1500

ctgctcccag gacagtgaaa gaacttacgg tatcggctgg agataaccta attataactt   1560

tacccgacaa tgaagttgaa ctgaaggcct ttgttgcgcc agcgccacct gtagaaacaa   1620

cctacaacta tgaatggaat ttaataagcc accccacaga ctaccaaggt gaaataaaac   1680

aaggacacaa gcaaactctt aacctctctc aattgtccgt cggactttat gtcttcaaag   1740

tcactgtttc tagtgaaaac gcctttggag aaggatttgt caatgtcact gttaagcctg   1800

ccagaagagt caacctgcca cctgtagcag ttgtttctcc ccaactgcaa gagctcactt   1860

tgcctttgac gtcagccctc attgatggca gccaaagtac agatgatact gaaatagtga   1920

gttatcattg ggaagaaata aacgggccct tcatagaaga gaagacttca gttgactctc   1980

ccgtcttacg cttgtctaac cttgatcctg gtaactatag tttcaggttg actgttacag   2040

actcggacgg agccactaac tctacaactg cagccctaat agtgaacaat gctgtggact   2100

acccaccagt tgctaatgca ggaccaaatc acaccataac tttgccccaa aactccatca   2160

ctttgaatgg aaaccagagc agtgacgatc accagattgt cctctatgag tggtccctgg   2220

gtcctgggag tgagggcaaa catgtggtca tgcagggagt acagacgcca taccttcatt   2280

tatctgcaat gcaggaagga gattatacat ttcagctgaa ggtgacagat tcttcaaggc   2340

aacagtctac tgctgtggtg actgtgattg tccagcctga aaacaataga cctccagtgg   2400

ctgtggccgg ccctgataaa gagctgatct tcccagtgga aagtgctacc ctggatggga   2460

gcagcagcag cgatgaccac ggcattgtct tctaccactg ggagcacgtc agaggcccca   2520

gtgcagtgga gatggaaaat attgacaaag caatagccac tgtgactggt ctccaggtgg   2580

ggacctacca cttccgtttg acagtgaaag accagcaggg actgagcagc acgtccaccc   2640

tcactgtggc tgtgaagaag gaaaataata gtcctcccag agcccgggct ggtggcagac   2700

atgttcttgt gcttcccaat aattccatta ctttggatgg ttcaaggtct actgatgacc   2760

aaagaattgt gtcctatctg tggatccggg atggccagag tccagcagct ggagatgtca   2820

tcgatggctc tgaccacagt gtggctctgc agcttacgaa tctggtggag ggggtgtaca   2880

ctttccactt gcgagtcacc gacagtcagg gggcctcgga cacagacact gccactgtgg   2940

aagtgcagcc agaccctagg aagagtggcc tggtggagct gaccctgcag gttggtgttg   3000

ggcagctgac agagcagcgg aaggacaccc ttgtgaggca gctggctgtg ctgctgaacg   3060

tgctggactc ggacattaag gtccagaaga ttcgggccca ctcggatctc agcaccgtga   3120

ttgtgtttta tgtacagagc aggccgcctt tcaaggttct caaagctgct gaagtggccc   3180

gaaatctgca catgcggctc tcaaaggaga aggctgactt cttgcttttc aaggtcttga   3240

gggttgatac agcaggttgc cttctgaagt gttctggcca tggtcactgc gaccccctca   3300

caaagcgctg catttgctct cacttatgga tggagaacct tatacagcgt tatatctggg   3360

atggagagag caactgtgag tggagtatat tctatgtgac agtgttggct tttactctta   3420

ttgtgctaac aggaggtttc acttggcttt gcatctgctg ctgcaaaaga caaaaaagga   3480

ctaaaatcag gaaaaaaaca aagtacacca tcctggataa catggatgaa caggaaagaa   3540

tggaactgag gcccaaatat ggtatcaagc accgaagcac agagcacaac tccagcctga   3600

tggtatccga gtctgagttt gacagtgacc aggacacaat cttcagccga gaaaagatgg   3660

agagagggaa tccaaaggtt tccatgaatg gttccatcag aaatggagct tccttcagtt   3720

attgctcaaa ggacagataa tggcgcagtt cattgtaaag tggaaggacc ccttgaatcc   3780

aagaccagtc agtgggagtt acagcacaaa acccactctt ttagaatagt tcattgacct   3840

tcttccccag tgggttagat gtgtatcccc acgtactaaa agaccggttt ttgaaggcac   3900

aaaacaaaaa ctttgctctt ttaactgaga tgcttgttaa tagaaataaa ggctgggtaa   3960

aactctaagg tatatactta aaagagtttt gagtttttgt agctggcaca atctcatatt   4020

aaagatgaac aacgatttct atctgtagaa ccttagagaa ggtgaatgaa acaaggtttt   4080

aaaaagggat gatttctgtc ttagctgctg tgattgcctc taaggaacag cattctaaac   4140

acggtttctc ttgtaggacc tgcagtcaga tggctgtgta tgttaaaata gcttgtctaa   4200

gaggcacggg ccatctgtgg aggtacggag tcttgcatgt agcaagcttt ctgtgctgac   4260

ggcaacactc gcacagtgcc aagccctcct ggtttttaat tctgtgctat gtcaatggca   4320

gttttcatct ctctcaagaa agcagctgtt ggccattcaa gagctaagga agaatcgtat   4380

tctaaggact gaggcaatag aaaggggagg aggagcttaa tgccgtgcag gttgaaggta   4440

gcattgtaac attatctttt ctttctctaa gaaaaactac actgactcct ctcggtgttg   4500

tttagcagta tagttctcta atgtaaacgg atccccagtt tacattaaat gcaatagaag   4560

tgattaattc attaagcatt tattatgttc tgtaggctgt gcgtttggac tgccatagat   4620

agggataacg actcagcaat tgtgtatata ttccaaaact ctgaaataca gtcagtctta   4680

acttggatgg cgtggttatg atactctggt ccccgacagg tactttccaa aataacttga   4740

catagatgta ttcacttcat atgtttaaaa atacatttaa gtttttctac cgaataaatc   4800

ttatttcaaa catgaaagac aattaaaaca ttcccaccca caaagcagta ctcccgagca   4860

attaactgga gttaattgta gcctgctacg ttgactggtt cagggtagtt ccccatccac   4920

ccttggtcct gaggctggtg gccttggtgg tgcccttggc attttttgtg ggaagattag   4980

aatgagagat agaaccagtg ttgtggtacc aagtgtgagc acacctaaac aatatcctgt   5040

tgcacaatgc ttttttaaca catgggaaaa ctaggaatgc attgctgatg aagaagcaag   5100

gtatttaaac accagggcag gagtgccaga gaaaatgttt ccccatgggt tcttaaaaaa   5160

aattcagctt ttaggtgctt ttgtcatctc ccgcagtatt catcctcatg ggaccatctt   5220

atttttactt attgtaattt actggggaaa ggcagaacta aaaagtgtgt cattttattt   5280

ttaaaataat tgctttgctt atgcctacac tttctgtata actagccaat tcaatactgt   5340

ctatagtgtt agaaggaaaa tgtgattttt ttttttaacc agtattgagc ttcataagcc   5400

tagaatctgc cttatcaggt gaccagggtt atggttgttt gcatgcaaat gtgaatttct   5460

ggcatagggg acagcagccc aaatgtaaag tcatcgggcg taatgaggaa gaagggagtg   5520

aacatttacc gctttatgta cataacatat gcagtttaca tactcatttg atccttataa   5580

tcaaccttga agaggagata ctatcattct tatgttgcag atagccctct gaaggcccag   5640

agaggttaaa taacttccca gaggtcatgg ccaagaagta gtggctccaa gaactgaatg   5700

caaatttttt aaactgtaga gttctgcttt ccactaaaca aagaactcct gccttgatgg   5760

atggagggca aattctggtg gaacttttgg gccacctgaa agttctattc ccaggactaa   5820

gaggaatttc ttttaatgga tccagagagc caaggtcaga gggagagatg gcctgcatag   5880

tctcctgtgg atcacacccg ggccacccct ccctctaggt ttacagtgga cttcttctgc   5940

ccctcctcct tttctgtcct tggccatctc agcctggcct ctctgatcct tccatcacag   6000

aaggatcttg aatctctggg aaatcaaaca tcacagtagt gatcagaaag tgagtcctgt   6060

cttgtcaccc catttctcat cagaacaaag cacgagatgg aatgaccaac cagcattctt   6120

catggtggac tgcttatcat tgaggatctt tgggagataa agcacgctaa gagctctgga   6180

cagagaaaaa caggccctag aatatgggag tgggtgtttg tagggctcac aggctaacaa   6240

gcactttagt tgctggttta cattcaatga aggaggattc atacccatgg cattacaagg   6300

ctaagcatgt gtatgactaa ggaactatct gaaaaacatg cagcaaggta agaaaatgta   6360

ccactcaaca agccagtgat gccacctttt gtgcgcgggg aggagagtga ctaccattgt   6420

tttttgtgtg acaaagctat catggactat tttaatcttg gttttattgc ttaaaatata   6480

ttatttttcc ctatgtgttg acaaggtatt tctaatatca cactattaaa tatatgcact   6540

aatctaaata aaggtgtctg tattttctgt aatgcttatt tttaggggga aatttgtttt   6600

ctttatgctt cagggtagag ggatttccct tgagtatagg tcagcaaact gtggcctaca   6660

gcctgtgtgt gcacgcccca tgagccgaaa agtgggtctt atgttttcaa atggttaaaa   6720

ataaataaaa aaatttgaaa catgtgaact atatgacatt cagatttgtg ttcataaata   6780

aagttttatt ggaacatatc c                                             6801


<210>  1264
<211>  1072
<212>  PRT
<213>  Homosapiens

<400>  1264

Met Ala Pro Pro Thr Gly Val Leu Ser Ser Leu Leu Leu Leu Val Thr 
1               5                   10                  15      


Ile Ala Gly Cys Ala Arg Lys Gln Cys Ser Glu Gly Arg Thr Tyr Ser 
            20                  25                  30          


Asn Ala Val Ile Ser Pro Asn Leu Glu Thr Thr Arg Ile Met Arg Val 
        35                  40                  45              


Ser His Thr Phe Pro Val Val Asp Cys Thr Ala Ala Cys Cys Asp Leu 
    50                  55                  60                  


Ser Ser Cys Asp Leu Ala Trp Trp Phe Glu Gly Arg Cys Tyr Leu Val 
65                  70                  75                  80  


Ser Cys Pro His Lys Glu Asn Cys Glu Pro Lys Lys Met Gly Pro Ile 
                85                  90                  95      


Arg Ser Tyr Leu Thr Phe Val Leu Arg Pro Val Gln Arg Pro Ala Gln 
            100                 105                 110         


Leu Leu Asp Tyr Gly Asp Met Met Leu Asn Arg Gly Ser Pro Ser Gly 
        115                 120                 125             


Ile Trp Gly Asp Ser Pro Glu Asp Ile Arg Lys Asp Leu Pro Phe Leu 
    130                 135                 140                 


Gly Lys Asp Trp Gly Leu Glu Glu Met Ser Glu Tyr Ala Asp Asp Tyr 
145                 150                 155                 160 


Arg Glu Leu Glu Lys Asp Leu Leu Gln Pro Ser Gly Lys Gln Glu Pro 
                165                 170                 175     


Arg Gly Ser Ala Glu Tyr Thr Asp Trp Gly Leu Leu Pro Gly Ser Glu 
            180                 185                 190         


Gly Ala Phe Asn Ser Ser Val Gly Asp Ser Pro Ala Val Pro Ala Glu 
        195                 200                 205             


Thr Gln Gln Asp Pro Glu Leu His Tyr Leu Asn Glu Ser Ala Ser Thr 
    210                 215                 220                 


Pro Ala Pro Lys Leu Pro Glu Arg Ser Val Leu Leu Pro Leu Pro Thr 
225                 230                 235                 240 


Thr Pro Ser Ser Gly Glu Val Leu Glu Lys Glu Lys Ala Ser Gln Leu 
                245                 250                 255     


Gln Glu Gln Ser Ser Asn Ser Ser Gly Lys Glu Val Leu Met Pro Ser 
            260                 265                 270         


His Ser Leu Pro Pro Ala Ser Leu Glu Leu Ser Ser Val Thr Val Glu 
        275                 280                 285             


Lys Ser Pro Val Leu Thr Val Thr Pro Gly Ser Thr Glu His Ser Ile 
    290                 295                 300                 


Pro Thr Pro Pro Thr Ser Ala Ala Pro Ser Glu Ser Thr Pro Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Ser Pro Thr Thr Ala Pro Arg Thr Val Lys Glu Leu Thr 
                325                 330                 335     


Val Ser Ala Gly Asp Asn Leu Ile Ile Thr Leu Pro Asp Asn Glu Val 
            340                 345                 350         


Glu Leu Lys Ala Phe Val Ala Pro Ala Pro Pro Val Glu Thr Thr Tyr 
        355                 360                 365             


Asn Tyr Glu Trp Asn Leu Ile Ser His Pro Thr Asp Tyr Gln Gly Glu 
    370                 375                 380                 


Ile Lys Gln Gly His Lys Gln Thr Leu Asn Leu Ser Gln Leu Ser Val 
385                 390                 395                 400 


Gly Leu Tyr Val Phe Lys Val Thr Val Ser Ser Glu Asn Ala Phe Gly 
                405                 410                 415     


Glu Gly Phe Val Asn Val Thr Val Lys Pro Ala Arg Arg Val Asn Leu 
            420                 425                 430         


Pro Pro Val Ala Val Val Ser Pro Gln Leu Gln Glu Leu Thr Leu Pro 
        435                 440                 445             


Leu Thr Ser Ala Leu Ile Asp Gly Ser Gln Ser Thr Asp Asp Thr Glu 
    450                 455                 460                 


Ile Val Ser Tyr His Trp Glu Glu Ile Asn Gly Pro Phe Ile Glu Glu 
465                 470                 475                 480 


Lys Thr Ser Val Asp Ser Pro Val Leu Arg Leu Ser Asn Leu Asp Pro 
                485                 490                 495     


Gly Asn Tyr Ser Phe Arg Leu Thr Val Thr Asp Ser Asp Gly Ala Thr 
            500                 505                 510         


Asn Ser Thr Thr Ala Ala Leu Ile Val Asn Asn Ala Val Asp Tyr Pro 
        515                 520                 525             


Pro Val Ala Asn Ala Gly Pro Asn His Thr Ile Thr Leu Pro Gln Asn 
    530                 535                 540                 


Ser Ile Thr Leu Asn Gly Asn Gln Ser Ser Asp Asp His Gln Ile Val 
545                 550                 555                 560 


Leu Tyr Glu Trp Ser Leu Gly Pro Gly Ser Glu Gly Lys His Val Val 
                565                 570                 575     


Met Gln Gly Val Gln Thr Pro Tyr Leu His Leu Ser Ala Met Gln Glu 
            580                 585                 590         


Gly Asp Tyr Thr Phe Gln Leu Lys Val Thr Asp Ser Ser Arg Gln Gln 
        595                 600                 605             


Ser Thr Ala Val Val Thr Val Ile Val Gln Pro Glu Asn Asn Arg Pro 
    610                 615                 620                 


Pro Val Ala Val Ala Gly Pro Asp Lys Glu Leu Ile Phe Pro Val Glu 
625                 630                 635                 640 


Ser Ala Thr Leu Asp Gly Ser Ser Ser Ser Asp Asp His Gly Ile Val 
                645                 650                 655     


Phe Tyr His Trp Glu His Val Arg Gly Pro Ser Ala Val Glu Met Glu 
            660                 665                 670         


Asn Ile Asp Lys Ala Ile Ala Thr Val Thr Gly Leu Gln Val Gly Thr 
        675                 680                 685             


Tyr His Phe Arg Leu Thr Val Lys Asp Gln Gln Gly Leu Ser Ser Thr 
    690                 695                 700                 


Ser Thr Leu Thr Val Ala Val Lys Lys Glu Asn Asn Ser Pro Pro Arg 
705                 710                 715                 720 


Ala Arg Ala Gly Gly Arg His Val Leu Val Leu Pro Asn Asn Ser Ile 
                725                 730                 735     


Thr Leu Asp Gly Ser Arg Ser Thr Asp Asp Gln Arg Ile Val Ser Tyr 
            740                 745                 750         


Leu Trp Ile Arg Asp Gly Gln Ser Pro Ala Ala Gly Asp Val Ile Asp 
        755                 760                 765             


Gly Ser Asp His Ser Val Ala Leu Gln Leu Thr Asn Leu Val Glu Gly 
    770                 775                 780                 


Val Tyr Thr Phe His Leu Arg Val Thr Asp Ser Gln Gly Ala Ser Asp 
785                 790                 795                 800 


Thr Asp Thr Ala Thr Val Glu Val Gln Pro Asp Pro Arg Lys Ser Gly 
                805                 810                 815     


Leu Val Glu Leu Thr Leu Gln Val Gly Val Gly Gln Leu Thr Glu Gln 
            820                 825                 830         


Arg Lys Asp Thr Leu Val Arg Gln Leu Ala Val Leu Leu Asn Val Leu 
        835                 840                 845             


Asp Ser Asp Ile Lys Val Gln Lys Ile Arg Ala His Ser Asp Leu Ser 
    850                 855                 860                 


Thr Val Ile Val Phe Tyr Val Gln Ser Arg Pro Pro Phe Lys Val Leu 
865                 870                 875                 880 


Lys Ala Ala Glu Val Ala Arg Asn Leu His Met Arg Leu Ser Lys Glu 
                885                 890                 895     


Lys Ala Asp Phe Leu Leu Phe Lys Val Leu Arg Val Asp Thr Ala Gly 
            900                 905                 910         


Cys Leu Leu Lys Cys Ser Gly His Gly His Cys Asp Pro Leu Thr Lys 
        915                 920                 925             


Arg Cys Ile Cys Ser His Leu Trp Met Glu Asn Leu Ile Gln Arg Tyr 
    930                 935                 940                 


Ile Trp Asp Gly Glu Ser Asn Cys Glu Trp Ser Ile Phe Tyr Val Thr 
945                 950                 955                 960 


Val Leu Ala Phe Thr Leu Ile Val Leu Thr Gly Gly Phe Thr Trp Leu 
                965                 970                 975     


Cys Ile Cys Cys Cys Lys Arg Gln Lys Arg Thr Lys Ile Arg Lys Lys 
            980                 985                 990         


Thr Lys Tyr Thr Ile Leu Asp Asn  Met Asp Glu Gln Glu  Arg Met Glu 
        995                 1000                 1005             


Leu Arg  Pro Lys Tyr Gly Ile  Lys His Arg Ser Thr  Glu His Asn 
    1010                 1015                 1020             


Ser Ser  Leu Met Val Ser Glu  Ser Glu Phe Asp Ser  Asp Gln Asp 
    1025                 1030                 1035             


Thr Ile  Phe Ser Arg Glu Lys  Met Glu Arg Gly Asn  Pro Lys Val 
    1040                 1045                 1050             


Ser Met  Asn Gly Ser Ile Arg  Asn Gly Ala Ser Phe  Ser Tyr Cys 
    1055                 1060                 1065             


Ser Lys  Asp Arg 
    1070         


<210>  1265
<211>  1940
<212>  DNA
<213>  Homosapiens

<400>  1265
ggggcggtgc agaggcggca ggaagatgga gttggggagt tgcctggagg gcgggaggga     60

ggcggcggag gaagagggcg agcctgaggt gaaaaagcgg cgacttctgt gtgtggagtt    120

tgcctcggtc gcaagctgcg atgccgcagt ggctcagtgc ttcctggccg agaacgactg    180

ggagatggaa agggctctga actcctactt cgagcctccg gtggaggaga gcgccttgga    240

acgccgacct gaaaccatct ctgagcccaa gacctatgtt gacctaacca atgaagaaac    300

aactgattcc accacttcta aaatcagccc atctgaagat actcagcaag aaaatggcag    360

catgttctct ctcattacct ggaatattga tggattagat ctaaacaatc tgtcagagag    420

ggctcgaggg gtgtgttcct acttagcttt gtacagccca gatgtgatat ttctacagga    480

agttattccc ccatattata gctacctaaa gaagagatca agtaattatg agattattac    540

aggtcatgaa gaaggatatt tcacagctat aatgttgaag aaatcaagag tgaaattaaa    600

aagccaagag attattcctt ttccaagtac caaaatgatg agaaaccttt tatgtgtgca    660

tgtgaacgtg tcaggaaatg agctttgcct tatgacatcc catttggaga gcaccagagg    720

gcatgctgcg gaacgaatga atcagttaaa aatggtttta aagaaaatgc aagaggctcc    780

agagtcagct acagttatat ttgcaggaga tacaaatcta agggatcgag aggttaccag    840

atgtggtggt ttacccaaca acattgtgga tgtctgggag tttttgggca aacctaaaca    900

ttgccagtat acatgggata cacaaatgaa ctctaatctt ggaataactg ctgcttgtaa    960

acttcgtttt gatcgaatat ttttcagagc agcagcagaa gagggacaca ttattccccg   1020

aagtttggac cttcttggat tagaaaaact ggactgtggt agatttccta gtgatcactg   1080

gggtcttctg tgcaacttag atataatatt gtaaaatgct tttcaagtgt gggttttgcc   1140

ctgattgttg caaatacaat ttccaccttc tggaaaggta ggtttgctgt ggaggaaata   1200

atgtactaga tcattgtcac agaaaaacca actatgattt atggttgtgt tttcagaatt   1260

caacattaaa gattaatgtt tatttaaacg aacacattcc tgcattcagg atgtgaggcc   1320

atttaataaa aagggcacaa agcctgtcag agttttcaac ggtgcttata gctgccagct   1380

ggattccaaa caggtaccac attgtctctg agctaatgtt tatatttttc cattcaggca   1440

ccgaaatagt taatatttga aataagtctt caaaagaaaa cataagagat tattgagttc   1500

ttgggactgg atcctttatt tcataagttc agatcatctt aaatgaaaat gccatgatta   1560

tctgcagtta agtagatgac agctattcta catcagactt gatttttgtc agctaattac   1620

ataattggta agctataatt gaaaccttat ggcttaaaat tccttaactc ctttttgatt   1680

catgtttgta gtcatgttgt caacagaggc aaagttaagc ttgatgatgg ttaaaatcgg   1740

tttgatagca ccatgggaca tttttctaac aaaaataaat gcatgaagag acatagcctt   1800

ttagttttgc taattgtgaa atggaaatgc tttacaggaa gtaaatgcaa attactttta   1860

agtgtgcttt aaagaaaaat attttcccca caagagaaat ttaaataaag aattttattt   1920

gtttaaaaaa aaaaaaaaaa                                               1940


<210>  1266
<211>  362
<212>  PRT
<213>  Homosapiens

<400>  1266

Met Glu Leu Gly Ser Cys Leu Glu Gly Gly Arg Glu Ala Ala Glu Glu 
1               5                   10                  15      


Glu Gly Glu Pro Glu Val Lys Lys Arg Arg Leu Leu Cys Val Glu Phe 
            20                  25                  30          


Ala Ser Val Ala Ser Cys Asp Ala Ala Val Ala Gln Cys Phe Leu Ala 
        35                  40                  45              


Glu Asn Asp Trp Glu Met Glu Arg Ala Leu Asn Ser Tyr Phe Glu Pro 
    50                  55                  60                  


Pro Val Glu Glu Ser Ala Leu Glu Arg Arg Pro Glu Thr Ile Ser Glu 
65                  70                  75                  80  


Pro Lys Thr Tyr Val Asp Leu Thr Asn Glu Glu Thr Thr Asp Ser Thr 
                85                  90                  95      


Thr Ser Lys Ile Ser Pro Ser Glu Asp Thr Gln Gln Glu Asn Gly Ser 
            100                 105                 110         


Met Phe Ser Leu Ile Thr Trp Asn Ile Asp Gly Leu Asp Leu Asn Asn 
        115                 120                 125             


Leu Ser Glu Arg Ala Arg Gly Val Cys Ser Tyr Leu Ala Leu Tyr Ser 
    130                 135                 140                 


Pro Asp Val Ile Phe Leu Gln Glu Val Ile Pro Pro Tyr Tyr Ser Tyr 
145                 150                 155                 160 


Leu Lys Lys Arg Ser Ser Asn Tyr Glu Ile Ile Thr Gly His Glu Glu 
                165                 170                 175     


Gly Tyr Phe Thr Ala Ile Met Leu Lys Lys Ser Arg Val Lys Leu Lys 
            180                 185                 190         


Ser Gln Glu Ile Ile Pro Phe Pro Ser Thr Lys Met Met Arg Asn Leu 
        195                 200                 205             


Leu Cys Val His Val Asn Val Ser Gly Asn Glu Leu Cys Leu Met Thr 
    210                 215                 220                 


Ser His Leu Glu Ser Thr Arg Gly His Ala Ala Glu Arg Met Asn Gln 
225                 230                 235                 240 


Leu Lys Met Val Leu Lys Lys Met Gln Glu Ala Pro Glu Ser Ala Thr 
                245                 250                 255     


Val Ile Phe Ala Gly Asp Thr Asn Leu Arg Asp Arg Glu Val Thr Arg 
            260                 265                 270         


Cys Gly Gly Leu Pro Asn Asn Ile Val Asp Val Trp Glu Phe Leu Gly 
        275                 280                 285             


Lys Pro Lys His Cys Gln Tyr Thr Trp Asp Thr Gln Met Asn Ser Asn 
    290                 295                 300                 


Leu Gly Ile Thr Ala Ala Cys Lys Leu Arg Phe Asp Arg Ile Phe Phe 
305                 310                 315                 320 


Arg Ala Ala Ala Glu Glu Gly His Ile Ile Pro Arg Ser Leu Asp Leu 
                325                 330                 335     


Leu Gly Leu Glu Lys Leu Asp Cys Gly Arg Phe Pro Ser Asp His Trp 
            340                 345                 350         


Gly Leu Leu Cys Asn Leu Asp Ile Ile Leu 
        355                 360         


<210>  1267
<211>  753
<212>  DNA
<213>  Homosapiens

<400>  1267
gcgcttcgtc acaagggtgc gaggaaagtc agtgagcaaa tcgcggacca ccggggctgc     60

cagctcgcct gactcccggc ctcttgcgct cctaggggcg gagaagggtg cgggctcttc    120

gccctttgtg tcctccttct ttcactaact tctggacttt ccagctcttc cgaagttcgt    180

tcttgcgcaa agcccaaagg ctggaaaacc gtccacgatg accagcatga ctcagtctct    240

gcgggaggtg ataaaggcca tgaccaaggc tcgcaatttt gagagagttt tgggaaagat    300

tactcttgtc tctgctgctc ctgggaaagt gatttgtgaa atgaaagtag aagaagagca    360

taccaatgca ataggcactc tccacggcgg tttgacagcc acgttagtag ataacatatc    420

aacaatggct ctgctatgca cggaaagggg agcacccgga gtcagtgtcg atatgaacat    480

aacgtacatg tcacctgcaa aattaggaga agatatagtg attacagcac atgttctgaa    540

gcaaggaaaa acacttgcat ttacctctgt ggatctgacc aacaaggcca caggaaaatt    600

aatagcacaa ggaagacaca caaaacacct gggaaactga gagaacagca gaatgaccta    660

aagaaaccca acaatgaata tcaagtatag atttgactca aacaattgta atttttgaaa    720

taaactagca aaaccagaaa aaaaaaaaaa aaa                                 753


<210>  1268
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  1268

Met Thr Ser Met Thr Gln Ser Leu Arg Glu Val Ile Lys Ala Met Thr 
1               5                   10                  15      


Lys Ala Arg Asn Phe Glu Arg Val Leu Gly Lys Ile Thr Leu Val Ser 
            20                  25                  30          


Ala Ala Pro Gly Lys Val Ile Cys Glu Met Lys Val Glu Glu Glu His 
        35                  40                  45              


Thr Asn Ala Ile Gly Thr Leu His Gly Gly Leu Thr Ala Thr Leu Val 
    50                  55                  60                  


Asp Asn Ile Ser Thr Met Ala Leu Leu Cys Thr Glu Arg Gly Ala Pro 
65                  70                  75                  80  


Gly Val Ser Val Asp Met Asn Ile Thr Tyr Met Ser Pro Ala Lys Leu 
                85                  90                  95      


Gly Glu Asp Ile Val Ile Thr Ala His Val Leu Lys Gln Gly Lys Thr 
            100                 105                 110         


Leu Ala Phe Thr Ser Val Asp Leu Thr Asn Lys Ala Thr Gly Lys Leu 
        115                 120                 125             


Ile Ala Gln Gly Arg His Thr Lys His Leu Gly Asn 
    130                 135                 140 


<210>  1269
<211>  2424
<212>  DNA
<213>  Homosapiens

<400>  1269
tggtcgagtt tttttttttt tttttttttt tggaaagcaa ggatcacact tccccctccc     60

tgttccttaa tcccttttct aaaaaggggg gaaaatccgg atggatttta gggattggtc    120

tggtgtcagc tgtgtcttat tgcacaccta aatcctgatt ataggctttt catttctccg    180

caaagccttt attttggcag ttaagccaaa tgtgttttcc agaaagttag ttattttctc    240

ctctttcttt cctttctttc ctcccttttt cccgtctgac cccaaacgtt attgtccaaa    300

catgactgga cagcagcttt tgtttcttga ccctgtaata tgacagtctg ctaatattga    360

cagaaggtgc agtttttggg ttatagtcgt gattttcgct aatcaatcat attagcagga    420

aaaaaaatga cttgtttctg ttgtacttga gtcttaagaa aaagtgccca tagtttagtg    480

acaatttcca aaggctttag taccacctgt atttcaaaat gggggaccca aactcccgga    540

agaaacaagc tctgaacaga ctacgtgctc agcttagaaa gaaaaaagaa tctctagctg    600

accagtttga cttcaagatg tatattgcct ttgtattcaa ggagaagaag aaaaagtcag    660

cactttttga agtgtctgag gttataccag tcatgacaaa taattatgaa gaaaatatcc    720

tgaaaggtgt gcgagattcc agctattcct tggaaagttc cctagagctt ttacagaagg    780

atgtggtaca gctccatgct cctcgatatc agtctatgag aagggatgta attggctgta    840

ctcaggagat ggatttcatt ctttggcctc ggaatgatat tgaaaaaatc gtctgtctcc    900

tgttttctag gtggaaagaa tctgatgagc cttttaggcc tgttcaggcc aaatttgagt    960

ttcatcatgg tgactatgaa aaacagtttc tgcatgtact gagccgcaag gacaagactg   1020

gaatcgttgt caacaatcct aaccagtcag tgtttctctt cattgacaga cagcacttgc   1080

agactccaaa aaacaaagct acaatcttca agttatgcag catctgcctc tacctgccac   1140

aggaacagct cacccactgg gcagttggca ccatagagga tcacctccgt ccttatatgc   1200

cagagtagag tactgaccag caaaatggag aagatcagag aatgcagcag cagttttttt   1260

tcttgttttc ttaccacttt attctttcag agtttaaaga aaatggactc atgcacagaa   1320

cactatgcat tttgaaactt gttcatcctg gattttttta aatcattttt atctcagaac   1380

ttaaacaaaa attagatgtc gtgcacggac tgtgtgaaag aagatgcttt gcatatttgc   1440

tgcactgcat cagtatctta ctaaaaatgt gaaatgaaag gactattgta cactgaaatg   1500

cttaaatgta tctgaaagca caaggtgata ctcattttta tggtcttccc atttgtgctg   1560

gtttttgcct ctttgacatc tgtcatcagt atttagaggg tgagaagtga atgtaacagg   1620

tataaataac atttttaaaa acaataactt tgctataatc acagttgttc cagagcactg   1680

tcagatacat tctaatgacc agaactggtt taaaaaaaga aaatacaacc atgggaaaga   1740

aatcttaaat gaaaaacgca tctcattgta ggcatttttg cctcatattt tactgggcca   1800

tgtttgtttc ctggtactca tgtatttttt ttttttccag atctctttcc ccaagttgct   1860

attgtaagag tattctgctg cgtgtggatg cagttataca cattaaagca gatctggagt   1920

ctgaagtagc tataaagcag ctataaaaca gaaatacatg catagctgca gaaaccatga   1980

taggtagagg acttttcttt tggttttgtt ttgttttgtt ttgttttgtt tttggtttta   2040

cagagaagag atttttatta caaagaaaaa aattccagtg aattgtgcag aaatgctggt   2100

ttttacacca tcctaaagaa aaactttaca agggtgtttt ggagtagaaa aaaggttata   2160

aagttggaat cttaaattgt aaaattaacc attgagtgtc aaagttctaa aagcagaact   2220

catttcgtgc aatgaacata aggaaagact actgtatagg tttttttttt tctcctttta   2280

aatgaagaaa agctttgctt aagggttgca tacttttatt ggagtaaatc tgaatgatcc   2340

tactcctttg gagtaagact agtgcttacc agtttccaat tgtatttagc ttctgttgga   2400

atttgaaaaa aaaaaaaaaa aaaa                                          2424


<210>  1270
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  1270

Met Gly Asp Pro Asn Ser Arg Lys Lys Gln Ala Leu Asn Arg Leu Arg 
1               5                   10                  15      


Ala Gln Leu Arg Lys Lys Lys Glu Ser Leu Ala Asp Gln Phe Asp Phe 
            20                  25                  30          


Lys Met Tyr Ile Ala Phe Val Phe Lys Glu Lys Lys Lys Lys Ser Ala 
        35                  40                  45              


Leu Phe Glu Val Ser Glu Val Ile Pro Val Met Thr Asn Asn Tyr Glu 
    50                  55                  60                  


Glu Asn Ile Leu Lys Gly Val Arg Asp Ser Ser Tyr Ser Leu Glu Ser 
65                  70                  75                  80  


Ser Leu Glu Leu Leu Gln Lys Asp Val Val Gln Leu His Ala Pro Arg 
                85                  90                  95      


Tyr Gln Ser Met Arg Arg Asp Val Ile Gly Cys Thr Gln Glu Met Asp 
            100                 105                 110         


Phe Ile Leu Trp Pro Arg Asn Asp Ile Glu Lys Ile Val Cys Leu Leu 
        115                 120                 125             


Phe Ser Arg Trp Lys Glu Ser Asp Glu Pro Phe Arg Pro Val Gln Ala 
    130                 135                 140                 


Lys Phe Glu Phe His His Gly Asp Tyr Glu Lys Gln Phe Leu His Val 
145                 150                 155                 160 


Leu Ser Arg Lys Asp Lys Thr Gly Ile Val Val Asn Asn Pro Asn Gln 
                165                 170                 175     


Ser Val Phe Leu Phe Ile Asp Arg Gln His Leu Gln Thr Pro Lys Asn 
            180                 185                 190         


Lys Ala Thr Ile Phe Lys Leu Cys Ser Ile Cys Leu Tyr Leu Pro Gln 
        195                 200                 205             


Glu Gln Leu Thr His Trp Ala Val Gly Thr Ile Glu Asp His Leu Arg 
    210                 215                 220                 


Pro Tyr Met Pro Glu 
225                 


<210>  1271
<211>  1215
<212>  DNA
<213>  Homosapiens

<400>  1271
cgtcagttgg tcacgtggtt gttcggagcg ggcgagcgga gttagcaggg ctttactgca     60

gagcgcgccg ggcactccag cgaccgtggg gatcagcgta ggtgagctgt ggccttttgc    120

gaggtgctgc agccatagct acgtgcgttc gctacgagga ttgagcgtct ccacccagta    180

agtgggcaag aggcggcagg aagtgggtac gcaggggcgc aaggcgcaca gcctctagac    240

gactcgcttt ccctccggcc aacctctgaa gccgcgtcct actttgacag ctgcagggcc    300

gcggcctggt cttctgtgct tcaccatcta cataatgaat cccagtatga agcagaaaca    360

agaagaaatc aaagagaata taaagaatag ttctgtccca agaagaactc tgaagatgat    420

tcagccttct gcatctggat ctcttgttgg aagagaaaat gagctgtccg caggcttgtc    480

caaaaggaaa catcggaatg accacttaac atctacaact tccagccctg gggttattgt    540

cccagaatct agtgaaaata aaaatcttgg aggagtcacc caggagtcat ttgatcttat    600

gattaaagaa aatccatcct ctcagtattg gaaggaagtg gcagaaaaac ggagaaaggc    660

gctgtatgaa gcacttaagg aaaatgagaa acttcataaa gaaattgaac aaaaggacaa    720

tgaaattgcc cgcctgaaaa aggagaataa agaactggca gaagtagcag aacatgtaca    780

gtatatggca gagctaatag agagactgaa tggtgaacct ctggataatt ttgaatcact    840

ggataatcag gaatttgatt ctgaagaaga aactgttgag gattctctag tggaagactc    900

agaaattggc acgtgtgctg aaggaactgt atcttcctct acggatgcaa agccatgtat    960

atgaaatgca ttaatatttg actgttgaga attttactgc cgaagtttac ctccactagt   1020

tctttgtagc agagtacata actacataat gccaactctg gaatcaaatt tccttgtttg   1080

aatcctggga ccctattgca ttaaagtaca aatactatgt atttttaatc tatgatggtt   1140

tatgtgaata ggattttctc agttgtcagc catgacttat gtttattact aaataaactt   1200

caaactcctg ttgaa                                                    1215


<210>  1272
<211>  209
<212>  PRT
<213>  Homosapiens

<400>  1272

Met Asn Pro Ser Met Lys Gln Lys Gln Glu Glu Ile Lys Glu Asn Ile 
1               5                   10                  15      


Lys Asn Ser Ser Val Pro Arg Arg Thr Leu Lys Met Ile Gln Pro Ser 
            20                  25                  30          


Ala Ser Gly Ser Leu Val Gly Arg Glu Asn Glu Leu Ser Ala Gly Leu 
        35                  40                  45              


Ser Lys Arg Lys His Arg Asn Asp His Leu Thr Ser Thr Thr Ser Ser 
    50                  55                  60                  


Pro Gly Val Ile Val Pro Glu Ser Ser Glu Asn Lys Asn Leu Gly Gly 
65                  70                  75                  80  


Val Thr Gln Glu Ser Phe Asp Leu Met Ile Lys Glu Asn Pro Ser Ser 
                85                  90                  95      


Gln Tyr Trp Lys Glu Val Ala Glu Lys Arg Arg Lys Ala Leu Tyr Glu 
            100                 105                 110         


Ala Leu Lys Glu Asn Glu Lys Leu His Lys Glu Ile Glu Gln Lys Asp 
        115                 120                 125             


Asn Glu Ile Ala Arg Leu Lys Lys Glu Asn Lys Glu Leu Ala Glu Val 
    130                 135                 140                 


Ala Glu His Val Gln Tyr Met Ala Glu Leu Ile Glu Arg Leu Asn Gly 
145                 150                 155                 160 


Glu Pro Leu Asp Asn Phe Glu Ser Leu Asp Asn Gln Glu Phe Asp Ser 
                165                 170                 175     


Glu Glu Glu Thr Val Glu Asp Ser Leu Val Glu Asp Ser Glu Ile Gly 
            180                 185                 190         


Thr Cys Ala Glu Gly Thr Val Ser Ser Ser Thr Asp Ala Lys Pro Cys 
        195                 200                 205             


Ile 
    


<210>  1273
<211>  2452
<212>  DNA
<213>  Homosapiens

<400>  1273
cgcaagaatg catacaaact ccagggctgc tctctcctgg agagggaggg aggggattta     60

aaaacctgca gcaacatggg ggaggaggct gtttgtcctt ctctctctgg ggaagtaact    120

cgctcaaact gccttccttg ctgagctgct tcgcgtagct ttgaggaagg tctagtgaaa    180

ttggtctttc cattacatct ggatgtacta ccagagagtt ctgctgctgt tgtttttttt    240

agcttttctt tctttgagtc tttaaagggc aattgtcgac actctgcaaa cataccgatt    300

tgttgtctgc ccactttgga gtcttcaatc tgggcagtaa ctatttaccc tttttcctgc    360

tagcctgtcc ccctctctgg attgaagtca cctgctaaga caatggacta ccgaccagac    420

tcccggaaat catgttggta ggatcccagt ctttttcgcc tggagggccc aatgggatca    480

ttagaagcca gtcctttgcg ggtttcagcg gcctccagga aaggcgatcc aggtgtaact    540

ccttcattga aaattcctcc gctctcaaga agcctcaggc caaactgaag aaaatgcaca    600

atttaggcca caaaaacaac aatcccccca aagagcctca gcctaaaagg gtggaagaag    660

tctacagggc cttgaaaaat ggacttgatg aatatctgga ggttcaccag acggagctgg    720

acaagttgac agctcagtta aaagatatga aaagaaactc tcgcctgggt gtactgtatg    780

acctagacaa gcaaattaaa acaattgaaa gatacatgag acgcctggag tttcatataa    840

gtaaggtaga tgaactctat gaagcttatt gtatccagcg acgcctccag gatggtgcca    900

gcaaaatgaa gcaagccttc gcaacatccc ctgccagcaa agctgcccgg gagagtctga    960

cagagatcaa tcggagcttc aaggagtaca cagagaatat gtgcaccatt gaagtggagc   1020

tagagaatct gctgggagaa ttctccatca agatgaaagg tctggctggc tttgcacgcc   1080

tctgtcctgg agatcaatat gaaattttca tgaagtatgg ccggcagcgg tggaaactga   1140

aaggcaaaat agaagtaaat ggcaagcaga gctgggatgg agaagaaaca gtttttctgc   1200

ccctgatagt tgggttcatc tccatcaagg tcacggagct caaagggcta gcaactcaca   1260

tcctggtagg tagcgtgacc tgtgagacca aagagctgtt tgcagcccga cctcaggtag   1320

tggctgtcga catcaatgac cttggtacca tcaaactgaa cctggaaatc acctggtatc   1380

catttgacgt ggaggacatg accgcatcct caggcgctgg gaacaaggca gcagcccttc   1440

agaggagaat gtccatgtac agccagggta ccccggaaac gcccaccttc aaagaccact   1500

ccttcttttc aaatctacct gatgacatct ttgaaaatgg aaaggcagcc gaggagaaaa   1560

tgccactgtc gctcagcttc agtgacctgc ccaacgggga ctgcgccctc acctcccact   1620

caacaggctc cccttccaac tcaacaaatc cagaaattac catcacccct gcggagttta   1680

acctcagcag cttggcctcc cagaatgagg gtatggatga caccagctca gcatcttcca   1740

ggaactccct gggagaaggc caagagccaa agtcacacct gaaggaggaa gacccagagg   1800

agcccagaaa acctgcctcg gccccatctg aggcttgccg ccgacagtcc tcaggtgctg   1860

gggctgagca cctgttcctt gagaatgatg ttgcagaagc acttctgcaa gagtctgagg   1920

aggcctctga gctcaagcct gtggaactgg acacttcgga aggaaacatc acaaagcagc   1980

tggtcaagag gctcacatct gcagaggtgc caatggccac agacaggctg ctctctgagg   2040

gttctgttgg tggagaatct gaaggctgca gatcctttct agatggaagc ttagaggatg   2100

cttttaatgg gcttttactt gcattagaac cacataaaga gcagtataaa gagtttcagg   2160

atctgaacca agaagtcatg aatttggatg atattctaaa aaagtagaga agatcctcta   2220

atggatccca gtgtgcccat ccctcaacct cctcagtgat caactcatgg ccaatcttgt   2280

ttcctattct tcaacctgct gacttccctc tggattcttc tgcaaccagt cccagatatt   2340

gtgccatttt atccatggtt gtacttcttt tttggatata aagattttta aatgcatttt   2400

ttaaatgcta acaaaaaata aaaacttgaa acaaaaaaaa aaaaaaaaaa aa           2452


<210>  1274
<211>  591
<212>  PRT
<213>  Homosapiens

<400>  1274

Met Leu Val Gly Ser Gln Ser Phe Ser Pro Gly Gly Pro Asn Gly Ile 
1               5                   10                  15      


Ile Arg Ser Gln Ser Phe Ala Gly Phe Ser Gly Leu Gln Glu Arg Arg 
            20                  25                  30          


Ser Arg Cys Asn Ser Phe Ile Glu Asn Ser Ser Ala Leu Lys Lys Pro 
        35                  40                  45              


Gln Ala Lys Leu Lys Lys Met His Asn Leu Gly His Lys Asn Asn Asn 
    50                  55                  60                  


Pro Pro Lys Glu Pro Gln Pro Lys Arg Val Glu Glu Val Tyr Arg Ala 
65                  70                  75                  80  


Leu Lys Asn Gly Leu Asp Glu Tyr Leu Glu Val His Gln Thr Glu Leu 
                85                  90                  95      


Asp Lys Leu Thr Ala Gln Leu Lys Asp Met Lys Arg Asn Ser Arg Leu 
            100                 105                 110         


Gly Val Leu Tyr Asp Leu Asp Lys Gln Ile Lys Thr Ile Glu Arg Tyr 
        115                 120                 125             


Met Arg Arg Leu Glu Phe His Ile Ser Lys Val Asp Glu Leu Tyr Glu 
    130                 135                 140                 


Ala Tyr Cys Ile Gln Arg Arg Leu Gln Asp Gly Ala Ser Lys Met Lys 
145                 150                 155                 160 


Gln Ala Phe Ala Thr Ser Pro Ala Ser Lys Ala Ala Arg Glu Ser Leu 
                165                 170                 175     


Thr Glu Ile Asn Arg Ser Phe Lys Glu Tyr Thr Glu Asn Met Cys Thr 
            180                 185                 190         


Ile Glu Val Glu Leu Glu Asn Leu Leu Gly Glu Phe Ser Ile Lys Met 
        195                 200                 205             


Lys Gly Leu Ala Gly Phe Ala Arg Leu Cys Pro Gly Asp Gln Tyr Glu 
    210                 215                 220                 


Ile Phe Met Lys Tyr Gly Arg Gln Arg Trp Lys Leu Lys Gly Lys Ile 
225                 230                 235                 240 


Glu Val Asn Gly Lys Gln Ser Trp Asp Gly Glu Glu Thr Val Phe Leu 
                245                 250                 255     


Pro Leu Ile Val Gly Phe Ile Ser Ile Lys Val Thr Glu Leu Lys Gly 
            260                 265                 270         


Leu Ala Thr His Ile Leu Val Gly Ser Val Thr Cys Glu Thr Lys Glu 
        275                 280                 285             


Leu Phe Ala Ala Arg Pro Gln Val Val Ala Val Asp Ile Asn Asp Leu 
    290                 295                 300                 


Gly Thr Ile Lys Leu Asn Leu Glu Ile Thr Trp Tyr Pro Phe Asp Val 
305                 310                 315                 320 


Glu Asp Met Thr Ala Ser Ser Gly Ala Gly Asn Lys Ala Ala Ala Leu 
                325                 330                 335     


Gln Arg Arg Met Ser Met Tyr Ser Gln Gly Thr Pro Glu Thr Pro Thr 
            340                 345                 350         


Phe Lys Asp His Ser Phe Phe Ser Asn Leu Pro Asp Asp Ile Phe Glu 
        355                 360                 365             


Asn Gly Lys Ala Ala Glu Glu Lys Met Pro Leu Ser Leu Ser Phe Ser 
    370                 375                 380                 


Asp Leu Pro Asn Gly Asp Cys Ala Leu Thr Ser His Ser Thr Gly Ser 
385                 390                 395                 400 


Pro Ser Asn Ser Thr Asn Pro Glu Ile Thr Ile Thr Pro Ala Glu Phe 
                405                 410                 415     


Asn Leu Ser Ser Leu Ala Ser Gln Asn Glu Gly Met Asp Asp Thr Ser 
            420                 425                 430         


Ser Ala Ser Ser Arg Asn Ser Leu Gly Glu Gly Gln Glu Pro Lys Ser 
        435                 440                 445             


His Leu Lys Glu Glu Asp Pro Glu Glu Pro Arg Lys Pro Ala Ser Ala 
    450                 455                 460                 


Pro Ser Glu Ala Cys Arg Arg Gln Ser Ser Gly Ala Gly Ala Glu His 
465                 470                 475                 480 


Leu Phe Leu Glu Asn Asp Val Ala Glu Ala Leu Leu Gln Glu Ser Glu 
                485                 490                 495     


Glu Ala Ser Glu Leu Lys Pro Val Glu Leu Asp Thr Ser Glu Gly Asn 
            500                 505                 510         


Ile Thr Lys Gln Leu Val Lys Arg Leu Thr Ser Ala Glu Val Pro Met 
        515                 520                 525             


Ala Thr Asp Arg Leu Leu Ser Glu Gly Ser Val Gly Gly Glu Ser Glu 
    530                 535                 540                 


Gly Cys Arg Ser Phe Leu Asp Gly Ser Leu Glu Asp Ala Phe Asn Gly 
545                 550                 555                 560 


Leu Leu Leu Ala Leu Glu Pro His Lys Glu Gln Tyr Lys Glu Phe Gln 
                565                 570                 575     


Asp Leu Asn Gln Glu Val Met Asn Leu Asp Asp Ile Leu Lys Lys 
            580                 585                 590     


<210>  1275
<211>  811
<212>  DNA
<213>  Homosapiens

<400>  1275
tttgcagacg ccgccgccga ggaaaaccgt gtgctattag ccatggtcaa ccccaccatg     60

ttcttcgaca ttgccgtcga cggtgagccc ttgggccgca tctcctttga ggtaaggggc    120

ctggaaacca agaagtgact gctcatctaa tccataaagc tatgttaaca gattggagct    180

gtttgcagac aaggtcccaa agacagcaga aaattttcgt gctctgagca ctggagagaa    240

aggatttggt tataagggtt cctgctttca cagaattatt ccagggttta tgtgtcaggg    300

tggtgacttc acacgccata atggcactgg tggcaagtca ccactgggag aaatttgaag    360

atgagaactt catcctaaag catacaggtc ctgaaatctt gtccatggca aatgctggac    420

ccaacacaaa tggttcccag tttttcatct gcactgccaa gactgagtgg ttggatggca    480

agcatgtggt ctttggcaaa gtgaaagaag gcatgaatat tgtggaggcc atggagcgct    540

ttgggtccag gaatggcaag accagcaaga agatcaccat tgctgactgt ggacaactcg    600

aataagtttg acttgtgttt tatcttaacc accagatcat tccttctgta gctcaggaga    660

gcacccctcc accccatttg cttgcagtat cccagtatct ttgtgctctt gctgcagttc    720

cctttgggtt ccatgttttc cttgttccct cccatgccta gctggattgc agagttaagt    780

ttatgattat gaaataaaaa ctaaataaca a                                   811


<210>  1276
<211>  2201
<212>  DNA
<213>  Homosapiens

<400>  1276
atcctgttgt gcctatcacc tgttgaagtt gccagtctta aggaagggat caatttcttt     60

cgcaataaga gcactggcaa agactacgtc ttgtacaaga ataagagccg actgagggca    120

tgcaagaata tgtgcaagca ccaaggaggc ctgttcataa aagatatcga ggatttagcc    180

ggaagttgtt gaaatggatg aaaacaacgg acttttgctt ttagaactga atcctcctaa    240

cccttgggac ttacagccca gatctcctga agagttggct tttggagaag tacagataac    300

atatctcact catgcctgca tggacctcaa gttaggagac aagagaatgg tgtttgaccc    360

ttggttaatc ggtcctgctt ttgcccgtgg atggtggttg ctccatgagc ctccatctga    420

ttggctggag aggctgtgcc aggcagacct cgtttacatc agtcatctgc actcagacca    480

cctgagttac cccacactga aaaagcttgc tgggagaaga ccagatattc ccatttatgt    540

tggaaacaca gaaaggcctg tattttggaa tctgaatcag agcggtgtcc agttgactaa    600

tatcaatgtc gtgccatttg gaatatggca gcaggtggac aaaaatcttc gattcatgat    660

cttgatggat ggtgttcatc ctgagatgga cacttgcatt attgtggagt acaaaggtca    720

taaaatactc aatacagtag actgcaccag acccaatggg ggaaggctgc ctatgaaggt    780

tgctctaatg atgagtgatt ttgctggagg agcatcaggc tttccaatga ctttcagtgg    840

tggaaaattt acggaggaat ggaaagccca attcattaaa acagaaagga agaagctcct    900

gaactacaag gcttggctgg tgaagaacct gcaaccccga atttattgtc cctttgctgg    960

gtattttgtg gaatctcacc catcagacaa gtacatcaag gaaacaaaca ccaaaaatga   1020

cccaaatgaa ctcaacaatc ttatcaagaa aaactctgat gtgataacat ggacccctcg   1080

accgggagcc acccttgatc tgggaagaat gctgaaggat ccaacagaca gcaagggcat   1140

catagagcct ccagagggga caaaaattta caaggattcc tgggattttg aaccttattt   1200

ggaaatcttg aatgctgctc taggagatga aatatttctt cactcatcct ggataaaaga   1260

atacttcact tgggctggat ttaaagatta caaccttgtg gtcaggatga ttgagacaga   1320

tgaggacttc aatccttttc ctggaggata tgactatttg gttgactttt tagatttatc   1380

cttcccaaaa gaaagaccac aacgagaaca tccctatgag gaaatccata gccgggtgga   1440

tgtcatcaga cacgtggtga agaatggtct actctgggat gagttgtata taggattcca   1500

aacacggctc cagcgggatc ctgacatata ccatcacctg ttttggaatc attttcaaat   1560

aaaactcccc ctcacaccac ccaactggaa gtcattcctg atgtgctgtg agcagaatgg   1620

gcctgcgatt ttgcaagaat gcaaaaccac atgaaaattt caagaattca ctgatctgat   1680

gcaaaataaa aatttatcat tacatcttga acccaggaag cttacagcaa agagactatg   1740

ctttatgacg tcagcaatag ataattccac gttgcctttg tgatttgtat atatagctta   1800

catttgtgga ccactacata gccagattca aaaatatttt acttgttcca tccacagttc   1860

tctacagaaa gaaccaatga acccaatagg aacaaattct ctgtggaaaa caaagcatag   1920

ctgtagtaga tacgaatcca atcacagagg aaacaggaag agaaaaacat ccaagactac   1980

agtgaaaact ggaaatggtc tgttttcgtg atattcgtat gattaagatg caaatttttt   2040

cttaggaaaa tgtgattgtt aactagcatt ctgttttaca tgttgacatt tctaacacac   2100

acaccactga tttgaacttc aaaatttatt ttctgattat atatgctagg tctgattctg   2160

aagatacaag aattcaatgg tggaatttgt ctcctgaaat t                       2201


<210>  1277
<211>  2307
<212>  DNA
<213>  Homosapiens

<400>  1277
ccaaagacat cctttggtga tacttactgt gggattcaga gtggggtgca gaggacgacc     60

ctgcaaaggc acggactata agagagatct gtgcagctgc gcctcagggg gtgtcctggg    120

cccctgggca tgacaggagg gggaccactt gcagttctac tggaaaattt accacccttc    180

cagaatcctc tgaagatata caggtcgcaa ctagagtgag acccgagtac tgccttgggt    240

cagaatggct agagaaccga gaaaaaacgc agccctggac gcccagtctg cagaagacca    300

gacggggctc ctgaccgtga aggtggagaa ggaggaagcc tccgccttga cggcggaggt    360

gagagcaccc tgcagccctg ctcggggccc cgaacgctcc cgccagcgct tccgaggctt    420

ccgctacccg gaggctgcgg gcccccgcga ggcgttgagc cggctccgag aactctgcgg    480

acaatggctg cagcctgaga tgcacagcaa ggagcagatc ctggagctgc tggtgctgga    540

gcagttcctg accatcctgc cggggaatct gcagagctgg gtgcgggagc agcatccaga    600

gagcggggag gaggtggtgg tgctattgga gtatttggag aggcagctgg atgagccggc    660

gccgcaggtt cccgttggtg accaggggca agaactgctc tgttgcaaga tggcactatt    720

gacacaaact caagggtctc aaagtagcca gtgccagcca atgaaggctc tgttcaagca    780

tgaatctctg ggatcccagc ccttacacga tagagttctc caggttcctg ggcttgccca    840

gggagggtgc tgcagagaag atgcaatggt agcttccagg ctcactccag ggtcccaggg    900

tttgctgaaa atggaagatg tggccctgac cctcactcct gggtggacac agctggattc    960

atctcaggtg aacctctaca gagatgaaaa gcaggagaac catagcagcc tggtctccct   1020

tggtggtgaa atacagacta agagcaggga cttgcctcca gtcaagaagc ttccagaaaa   1080

ggagcatggg aagatatgcc acctgaggga agacattgcc cagattccta cacatgcaga   1140

agctggtgaa caggagggca ggttacaaag aaagcagaaa aatgccatag ggagtaggcg   1200

acattattgc catgaatgtg gaaagagttt tgctcaaagt tcaggcctga ctaaacacag   1260

gagaatccac actggtgaga aaccctatga atgtgaagac tgtggaaaga ccttcattgg   1320

gagctctgcc cttgtcattc atcagagagt ccacactggt gagaagccat atgagtgtga   1380

agaatgtggt aaggtcttca gtcacagctc aaaccttatc aaacaccaga gaacccacac   1440

tggggagaag ccctatgagt gtgatgactg tgggaagacc ttcagccaga gctgcagcct   1500

ccttgaacat cacaaaattc atactgggga gaagccatac cagtgcaata tgtgtggcaa   1560

agcctttagg cggaattcac atctcctgag acatcagagg attcatggtg ataaaaatgt   1620

tcagaatcct gagcacgggg agtcctggga aagtcagggt aggacggaaa gccagtggga   1680

aaatactgag gctcccgtgt cttataaatg taatgagtgt gagagaagtt tcacacggaa   1740

tagaagtctt attgaacatc agaaaatcca cactggtgag aaaccctatc agtgtgacac   1800

atgtggaaaa ggtttcactc gaacttcata ccttgttcaa catcagagaa gccatgtagg   1860

gaaaaaaact ctttcacagt gacccatggt attcatgcca acattggtgc tcatttgtca   1920

ctgaactgaa gccaccctgg agcccttaat ggttacagaa attgtggacc agggctttat   1980

ttaccactat acatcatcgg gtattagaaa atgtagtctg gctgagacga tgagttatct   2040

tctacattct agaaagtgat tggaagaagt catttgataa gaggccatgg gagagtggtc   2100

tggaagttgt aggacctaaa atagtttgtt ctcacccagt gtatttaaat ggccttctgg   2160

acttgttaat tgccctcagc cagcacttta ggacatctgg ttggatggct ctgatgtggg   2220

gggctgctgc tctgaccatt cattttgcct ctaatgaatc tttcacaaat tggtcagatc   2280

catgagaaaa aaaaaaaaaa aaaaaaa                                       2307


<210>  1278
<211>  545
<212>  PRT
<213>  Homosapiens

<400>  1278

Met Ala Arg Glu Pro Arg Lys Asn Ala Ala Leu Asp Ala Gln Ser Ala 
1               5                   10                  15      


Glu Asp Gln Thr Gly Leu Leu Thr Val Lys Val Glu Lys Glu Glu Ala 
            20                  25                  30          


Ser Ala Leu Thr Ala Glu Val Arg Ala Pro Cys Ser Pro Ala Arg Gly 
        35                  40                  45              


Pro Glu Arg Ser Arg Gln Arg Phe Arg Gly Phe Arg Tyr Pro Glu Ala 
    50                  55                  60                  


Ala Gly Pro Arg Glu Ala Leu Ser Arg Leu Arg Glu Leu Cys Gly Gln 
65                  70                  75                  80  


Trp Leu Gln Pro Glu Met His Ser Lys Glu Gln Ile Leu Glu Leu Leu 
                85                  90                  95      


Val Leu Glu Gln Phe Leu Thr Ile Leu Pro Gly Asn Leu Gln Ser Trp 
            100                 105                 110         


Val Arg Glu Gln His Pro Glu Ser Gly Glu Glu Val Val Val Leu Leu 
        115                 120                 125             


Glu Tyr Leu Glu Arg Gln Leu Asp Glu Pro Ala Pro Gln Val Pro Val 
    130                 135                 140                 


Gly Asp Gln Gly Gln Glu Leu Leu Cys Cys Lys Met Ala Leu Leu Thr 
145                 150                 155                 160 


Gln Thr Gln Gly Ser Gln Ser Ser Gln Cys Gln Pro Met Lys Ala Leu 
                165                 170                 175     


Phe Lys His Glu Ser Leu Gly Ser Gln Pro Leu His Asp Arg Val Leu 
            180                 185                 190         


Gln Val Pro Gly Leu Ala Gln Gly Gly Cys Cys Arg Glu Asp Ala Met 
        195                 200                 205             


Val Ala Ser Arg Leu Thr Pro Gly Ser Gln Gly Leu Leu Lys Met Glu 
    210                 215                 220                 


Asp Val Ala Leu Thr Leu Thr Pro Gly Trp Thr Gln Leu Asp Ser Ser 
225                 230                 235                 240 


Gln Val Asn Leu Tyr Arg Asp Glu Lys Gln Glu Asn His Ser Ser Leu 
                245                 250                 255     


Val Ser Leu Gly Gly Glu Ile Gln Thr Lys Ser Arg Asp Leu Pro Pro 
            260                 265                 270         


Val Lys Lys Leu Pro Glu Lys Glu His Gly Lys Ile Cys His Leu Arg 
        275                 280                 285             


Glu Asp Ile Ala Gln Ile Pro Thr His Ala Glu Ala Gly Glu Gln Glu 
    290                 295                 300                 


Gly Arg Leu Gln Arg Lys Gln Lys Asn Ala Ile Gly Ser Arg Arg His 
305                 310                 315                 320 


Tyr Cys His Glu Cys Gly Lys Ser Phe Ala Gln Ser Ser Gly Leu Thr 
                325                 330                 335     


Lys His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Glu Asp 
            340                 345                 350         


Cys Gly Lys Thr Phe Ile Gly Ser Ser Ala Leu Val Ile His Gln Arg 
        355                 360                 365             


Val His Thr Gly Glu Lys Pro Tyr Glu Cys Glu Glu Cys Gly Lys Val 
    370                 375                 380                 


Phe Ser His Ser Ser Asn Leu Ile Lys His Gln Arg Thr His Thr Gly 
385                 390                 395                 400 


Glu Lys Pro Tyr Glu Cys Asp Asp Cys Gly Lys Thr Phe Ser Gln Ser 
                405                 410                 415     


Cys Ser Leu Leu Glu His His Lys Ile His Thr Gly Glu Lys Pro Tyr 
            420                 425                 430         


Gln Cys Asn Met Cys Gly Lys Ala Phe Arg Arg Asn Ser His Leu Leu 
        435                 440                 445             


Arg His Gln Arg Ile His Gly Asp Lys Asn Val Gln Asn Pro Glu His 
    450                 455                 460                 


Gly Glu Ser Trp Glu Ser Gln Gly Arg Thr Glu Ser Gln Trp Glu Asn 
465                 470                 475                 480 


Thr Glu Ala Pro Val Ser Tyr Lys Cys Asn Glu Cys Glu Arg Ser Phe 
                485                 490                 495     


Thr Arg Asn Arg Ser Leu Ile Glu His Gln Lys Ile His Thr Gly Glu 
            500                 505                 510         


Lys Pro Tyr Gln Cys Asp Thr Cys Gly Lys Gly Phe Thr Arg Thr Ser 
        515                 520                 525             


Tyr Leu Val Gln His Gln Arg Ser His Val Gly Lys Lys Thr Leu Ser 
    530                 535                 540                 


Gln 
545 


<210>  1279
<211>  1639
<212>  DNA
<213>  Homosapiens

<400>  1279
caccagccag cctctgggtc tgtagcaacc gcccagcgtt gaggcgcggc tcatgccccc     60

agtatcccgg tccagctatt ccgaggacat cgtgggctct cggagaaggc gacgcagctc    120

ctcggggagc ccaccatccc cgcagagcag atgttcctct tgggatggct gttcccgctc    180

tcactcccgc ggccgtgagg gcctcaggcc tccttggagt gagttggacg tgggcgctct    240

ttaccccttt agtcgctctg ggtcgcgagg gcggctccca agattccgca actacgcctt    300

cgcgtcctcc tggtcgacct cgtatagtgg atatcgctac catcgtcact gctatgcaga    360

agaacggcag tcagcggaag actacgagaa ggaagagagc catcggcaga ggaggctgaa    420

ggagagagag aggattgggg aattgggagc gcctgaagtg tgggggccgt ctccaaagtt    480

ccctcagcta gattctgacg aacatacccc agttgaggat gaagaagagg taacgcatca    540

gaaaagcagc agttcagatt ccaactcgga agaacatagg aaaaagaaga ccagtcgttc    600

aagaaacaag aaaaaaagaa agaataagtc gtctaaaaga aagcatagga aatattctga    660

tagtgacagt aactcagagt ctgacacaaa ttctgactct gatgatgata aaaagagagt    720

taaagccaag aagaaaaaga agaaaaagaa acacaaaaca aagaaaaaga agaataagaa    780

aaccaaaaaa gaatccagtg actcaagctg taaagactca gaagaggact tgtcagaagc    840

tacctggatg gagcagccaa atgtggcaga tactatggat ttaatagggc cagaagcacc    900

tataatacat acctctcaag atgaaaaacc tttgaagtat ggccatgctt tgcttcccgg    960

tgaaggtgca gctatggctg agtatgtaaa agctggaaag cgaatcccac gaagaggtga   1020

aattgggttg acaagtgaag agatcggttc ttttgaatgc tcaggttatg tcatgagtgg   1080

tagcaggcat cgcagaatgg aggctgtacg actgcgtaag gagaaccaga tctacagtgc   1140

tgatgagaag agagctcttg catcctttaa ccaagaagag agacgaaaga gagaaagtaa   1200

gattttagcc agtttccgag agatggtgca caaaaagaca aaagagaaag atgacaagta   1260

aggacttact tgttgcacag caggaatttt aacaacaaaa attttatgtg accaaaagtg   1320

ttaaaaggct ttacagtgct actgtactta ccatattagt aagtccctca ggaaaaagct   1380

tcttttgaga tatctttagc agcttatttt ttgttatttt aactttaaaa agtaatatgt   1440

gcacatggtt ttaaaaatat tcaaccatta taggaggaga gttagtaaaa agtgaatctt   1500

tcactttagc ccctgacacc tttcccccaa aaatatatat tttggtgtct tatatacaga   1560

atatacattc tgtgcatata caagagtata tgttgcagca taaagattaa aagctattaa   1620

agtttttttt cgctcgtta                                                1639


<210>  1280
<211>  402
<212>  PRT
<213>  Homosapiens

<400>  1280

Met Pro Pro Val Ser Arg Ser Ser Tyr Ser Glu Asp Ile Val Gly Ser 
1               5                   10                  15      


Arg Arg Arg Arg Arg Ser Ser Ser Gly Ser Pro Pro Ser Pro Gln Ser 
            20                  25                  30          


Arg Cys Ser Ser Trp Asp Gly Cys Ser Arg Ser His Ser Arg Gly Arg 
        35                  40                  45              


Glu Gly Leu Arg Pro Pro Trp Ser Glu Leu Asp Val Gly Ala Leu Tyr 
    50                  55                  60                  


Pro Phe Ser Arg Ser Gly Ser Arg Gly Arg Leu Pro Arg Phe Arg Asn 
65                  70                  75                  80  


Tyr Ala Phe Ala Ser Ser Trp Ser Thr Ser Tyr Ser Gly Tyr Arg Tyr 
                85                  90                  95      


His Arg His Cys Tyr Ala Glu Glu Arg Gln Ser Ala Glu Asp Tyr Glu 
            100                 105                 110         


Lys Glu Glu Ser His Arg Gln Arg Arg Leu Lys Glu Arg Glu Arg Ile 
        115                 120                 125             


Gly Glu Leu Gly Ala Pro Glu Val Trp Gly Pro Ser Pro Lys Phe Pro 
    130                 135                 140                 


Gln Leu Asp Ser Asp Glu His Thr Pro Val Glu Asp Glu Glu Glu Val 
145                 150                 155                 160 


Thr His Gln Lys Ser Ser Ser Ser Asp Ser Asn Ser Glu Glu His Arg 
                165                 170                 175     


Lys Lys Lys Thr Ser Arg Ser Arg Asn Lys Lys Lys Arg Lys Asn Lys 
            180                 185                 190         


Ser Ser Lys Arg Lys His Arg Lys Tyr Ser Asp Ser Asp Ser Asn Ser 
        195                 200                 205             


Glu Ser Asp Thr Asn Ser Asp Ser Asp Asp Asp Lys Lys Arg Val Lys 
    210                 215                 220                 


Ala Lys Lys Lys Lys Lys Lys Lys Lys His Lys Thr Lys Lys Lys Lys 
225                 230                 235                 240 


Asn Lys Lys Thr Lys Lys Glu Ser Ser Asp Ser Ser Cys Lys Asp Ser 
                245                 250                 255     


Glu Glu Asp Leu Ser Glu Ala Thr Trp Met Glu Gln Pro Asn Val Ala 
            260                 265                 270         


Asp Thr Met Asp Leu Ile Gly Pro Glu Ala Pro Ile Ile His Thr Ser 
        275                 280                 285             


Gln Asp Glu Lys Pro Leu Lys Tyr Gly His Ala Leu Leu Pro Gly Glu 
    290                 295                 300                 


Gly Ala Ala Met Ala Glu Tyr Val Lys Ala Gly Lys Arg Ile Pro Arg 
305                 310                 315                 320 


Arg Gly Glu Ile Gly Leu Thr Ser Glu Glu Ile Gly Ser Phe Glu Cys 
                325                 330                 335     


Ser Gly Tyr Val Met Ser Gly Ser Arg His Arg Arg Met Glu Ala Val 
            340                 345                 350         


Arg Leu Arg Lys Glu Asn Gln Ile Tyr Ser Ala Asp Glu Lys Arg Ala 
        355                 360                 365             


Leu Ala Ser Phe Asn Gln Glu Glu Arg Arg Lys Arg Glu Ser Lys Ile 
    370                 375                 380                 


Leu Ala Ser Phe Arg Glu Met Val His Lys Lys Thr Lys Glu Lys Asp 
385                 390                 395                 400 


Asp Lys 
        


<210>  1281
<211>  2732
<212>  DNA
<213>  Homosapiens

<400>  1281
agcggagaag aaagcgctcc gaagagctag agctgacact cggcgatgag ctaagacgct     60

gtttcagagc gtttgggtcc tctgaggccc cttgaccagg agtgtctctg aagatacagt    120

ccaaagaaag ttctccaaaa caaggagaac agtctgaagc tggggatggc aacagcattg    180

gtgagtgccc attccctggc tcccctgaat ctgaagaagg aggggcttcg ggtagtgagg    240

gaggatcact actctacttg ggaacaggga ttcaagctgc aaggaaacag taaaggcctt    300

ggacaggagc cattgtgcaa acaattcagg cagttgcgtt atgaagagac cacaggacct    360

cgagaagcac taagtcggct ccgggagctc tgtcaacagt gctacagccc gagacccata    420

ccaaggagca gatcctggag ctgctggtgc tggagcagtt tctgatcatc ctgcctaagg    480

agctccaggc ccgggtgcag gagcatcacc cagagagcag ggaggacgtg gttgttgttc    540

tggaggattt gcagctggat cttggagaaa caggacaaca ggtggaccca gaccagccaa    600

agaaacaaaa aatacttgtg gaggagatgg cccctctgaa aggagtacag gaacagcagg    660

ttcggcatga gtgtgaagtt acaaagcctg agaaagagaa gggtgaggag acaaggattg    720

agaatgggaa gcttattgta gtaacagact cttgtggaag agtagagtca tctgggaaaa    780

tatctgaacc catggaggct cataatgagg gctctaactt ggaaaggcat caggccaagc    840

ccaaagagaa gattgagtat aaatgctcag aacgtgagca gagattcatc cagcacttgg    900

acctgattga acatgcgagt acacacacgg gaaagaaact ctgcgagtct gatgtgtgtc    960

agagttccag tcttacagga cataagaaag tcctctctag agagaaaggt catcagtgtc   1020

atgagtgtgg gaaagccttt cagaggagtt cacacctcgt cagacatcag aaaatccatc   1080

ttggtgagaa gccttatcag tgcaatgagt gtggcaaagt ctttagccag aatgcaggcc   1140

ttttggaaca tctcagaatt catactggag agaaacctta tctatgtatc cattgtggaa   1200

aaaattttag gcgcagctct caccttaatc gacatcagag aattcacagt caggaggagc   1260

cctgtgagtg caaggagtgt ggaaaaacct ttagtcaggc cttactcctc acccaccatc   1320

agagaatcca tagtcactcc aaaagccatc aatgtaacga gtgtggaaaa gctttcagtt   1380

tgacctcaga ccttattcga caccacagaa ttcatactgg agaaaaacct ttcaagtgta   1440

acatatgcca gaaagccttc cgactaaact cacaccttgc tcagcatgta agaatccaca   1500

atgaagaaaa accctatcag tgtagtgaat gtggagaagc cttcaggcaa aggtcaggtc   1560

tttttcaaca tcagagatat caccacaaag acaaactggc ttgatgaggt gttctctcct   1620

tgtagaacat cagagaaggc acattgacta gcaaacagca ctttaggaaa agtcaccgta   1680

gcccactgtg gcatcagaaa attcttgggg gctgagttgg aggctccctg cctctattct   1740

ctctcctttg ctttccttga agtcagcttt ggaccacaat aatttcactg tagatgatat   1800

gctaggatca aagttaaaca gcattcttca ctgcaggaca tctcagagca tgtaacataa   1860

ctgcatgatt atatactcta agcaatagag agcttcatga ctgagtaaga gttttgaagt   1920

cagcagtgaa tcaagtgccc acagatttgc aggcttaagc agaacaaggg aagattgata   1980

tttttggata tgctatagca gctttctcct atgaaataaa actgatgatg tttggaagta   2040

tactactctc aaaggtgtct ttaaagtaca ggttaatggt gaacattttc ccccagtggc   2100

ttcacctcat tcctcccact ggccttaccc cttccttccc cagtggaagc attttcaaaa   2160

gcaaagataa ttttcgctgg tgaacttcag aacttgcctt cagggttagc ttcatgtaat   2220

tttaccattt cccatcccca ttccccacca cattatgtca agattcaagt tataaattaa   2280

cgttttactt agactttgaa agagatttca tgagtaattt gaatgaacct tgctgaatta   2340

atctgaatag caactgtctg acttgataac tccagtgcca gtatagtggc tgctgcatag   2400

acactattca gtaaatgtct gatgaaagaa attggacttt ttccctttaa tactgatgat   2460

gcaattttga aatgttgctt gttctggaat acttcggaag ttaaacaata aagtcagctt   2520

ggagaggaga tcatgatctt tatactgtga atagcagaat gtcacagatg aagaatatta   2580

aaattagggg cgtccactcc aaaacatatc accagagtga caacttcagc cctcagcctc   2640

tgcaatccat atatatcctg gtcttgggag tccatagaat actgtttcct tctaataaag   2700

gtttcaaaca aaaaaaaaaa aaaaaaaaaa aa                                 2732


<210>  1282
<211>  325
<212>  PRT
<213>  Homosapiens

<400>  1282

Met Ala Pro Leu Lys Gly Val Gln Glu Gln Gln Val Arg His Glu Cys 
1               5                   10                  15      


Glu Val Thr Lys Pro Glu Lys Glu Lys Gly Glu Glu Thr Arg Ile Glu 
            20                  25                  30          


Asn Gly Lys Leu Ile Val Val Thr Asp Ser Cys Gly Arg Val Glu Ser 
        35                  40                  45              


Ser Gly Lys Ile Ser Glu Pro Met Glu Ala His Asn Glu Gly Ser Asn 
    50                  55                  60                  


Leu Glu Arg His Gln Ala Lys Pro Lys Glu Lys Ile Glu Tyr Lys Cys 
65                  70                  75                  80  


Ser Glu Arg Glu Gln Arg Phe Ile Gln His Leu Asp Leu Ile Glu His 
                85                  90                  95      


Ala Ser Thr His Thr Gly Lys Lys Leu Cys Glu Ser Asp Val Cys Gln 
            100                 105                 110         


Ser Ser Ser Leu Thr Gly His Lys Lys Val Leu Ser Arg Glu Lys Gly 
        115                 120                 125             


His Gln Cys His Glu Cys Gly Lys Ala Phe Gln Arg Ser Ser His Leu 
    130                 135                 140                 


Val Arg His Gln Lys Ile His Leu Gly Glu Lys Pro Tyr Gln Cys Asn 
145                 150                 155                 160 


Glu Cys Gly Lys Val Phe Ser Gln Asn Ala Gly Leu Leu Glu His Leu 
                165                 170                 175     


Arg Ile His Thr Gly Glu Lys Pro Tyr Leu Cys Ile His Cys Gly Lys 
            180                 185                 190         


Asn Phe Arg Arg Ser Ser His Leu Asn Arg His Gln Arg Ile His Ser 
        195                 200                 205             


Gln Glu Glu Pro Cys Glu Cys Lys Glu Cys Gly Lys Thr Phe Ser Gln 
    210                 215                 220                 


Ala Leu Leu Leu Thr His His Gln Arg Ile His Ser His Ser Lys Ser 
225                 230                 235                 240 


His Gln Cys Asn Glu Cys Gly Lys Ala Phe Ser Leu Thr Ser Asp Leu 
                245                 250                 255     


Ile Arg His His Arg Ile His Thr Gly Glu Lys Pro Phe Lys Cys Asn 
            260                 265                 270         


Ile Cys Gln Lys Ala Phe Arg Leu Asn Ser His Leu Ala Gln His Val 
        275                 280                 285             


Arg Ile His Asn Glu Glu Lys Pro Tyr Gln Cys Ser Glu Cys Gly Glu 
    290                 295                 300                 


Ala Phe Arg Gln Arg Ser Gly Leu Phe Gln His Gln Arg Tyr His His 
305                 310                 315                 320 


Lys Asp Lys Leu Ala 
                325 


<210>  1283
<211>  3062
<212>  DNA
<213>  Homosapiens

<400>  1283
agcggagaag aaagcgctcc gaagagctag agctgacact cggcgatgag ctaagacgct     60

gtttcagagc gtttgggtcc tctgaggccc cttgaccagg agtgtctctg aagatacagt    120

ccaaagaaag ttctccaaaa caaggagaac agtctgaagc tggggatggc aacagcattg    180

gtgagtgccc attccctggc tcccctgaat ctgaagaagg aggggcttcg ggtagtgagg    240

gaggatcact actctacttg ggaacaggga ttcaagctgc aaggaaacag taaaggcctt    300

ggacaggagc cattgtgcaa acaattcagg cagttgcgtt atgaagagac cacaggacct    360

cgagaagcac taagtcggct ccgggagctc tgtcaacagt gctacagccc gagacccata    420

ccaaggagca gatcctggag ctgctggtgc tggagcagtt tctgatcatc ctgcctaagg    480

agctccaggc ccgggtgcag gagcatcacc cagagagcag ggaggacgtg gttgttgttc    540

tggaggattt gcagctggat cttggagaaa caggacaaca ggtggtaagg gtcagatgtg    600

ctctttttca ggaatgcagg aattgagatc tctggccaga caggtggaca tgggctcatc    660

agcggaagga gaattactaa gctttgattc agtttttttc cagtctagct gttaatttcc    720

ttaggtctta cctcaacctt acctggccct tgcttggaga aaactgaatg tgcaccagat    780

tccccatctt cttttctttg cccctctggg gtttctcttt cttctctttt ttaacaccta    840

ggtgttttac tgaacagcag tttcctaaac ccacatatat ctaattatgc ctccatatac    900

ctaattgtcc ctaggaccca gaccagccaa agaaacaaaa aatacttgtg gaggagatgg    960

cccctctgaa aggagtacag gaacagcagg ttcggcatga gtgtgaagtt acaaagcctg   1020

agaaagagaa gggtgaggag acaaggattg agaatgggaa gcttattgta gtaacagact   1080

cttgtggaag agtagagtca tctgggaaaa tatctgaacc catggaggct cataatgagg   1140

gctctaactt ggaaaggcat caggccaagc ccaaagagaa gattgagtat aaatgctcag   1200

aacgtgagca gagattcatc cagcacttgg acctgattga acatgcgagt acacacacgg   1260

gaaagaaact ctgcgagtct gatgtgtgtc agagttccag tcttacagga cataagaaag   1320

tcctctctag agagaaaggt catcagtgtc atgagtgtgg gaaagccttt cagaggagtt   1380

cacacctcgt cagacatcag aaaatccatc ttggtgagaa gccttatcag tgcaatgagt   1440

gtggcaaagt ctttagccag aatgcaggcc ttttggaaca tctcagaatt catactggag   1500

agaaacctta tctatgtatc cattgtggaa aaaattttag gcgcagctct caccttaatc   1560

gacatcagag aattcacagt caggaggagc cctgtgagtg caaggagtgt ggaaaaacct   1620

ttagtcaggc cttactcctc acccaccatc agagaatcca tagtcactcc aaaagccatc   1680

aatgtaacga gtgtggaaaa gctttcagtt tgacctcaga ccttattcga caccacagaa   1740

ttcatactgg agaaaaacct ttcaagtgta acatatgcca gaaagccttc cgactaaact   1800

cacaccttgc tcagcatgta agaatccaca atgaagaaaa accctatcag tgtagtgaat   1860

gtggagaagc cttcaggcaa aggtcaggtc tttttcaaca tcagagatat caccacaaag   1920

acaaactggc ttgatgaggt gttctctcct tgtagaacat cagagaaggc acattgacta   1980

gcaaacagca ctttaggaaa agtcaccgta gcccactgtg gcatcagaaa attcttgggg   2040

gctgagttgg aggctccctg cctctattct ctctcctttg ctttccttga agtcagcttt   2100

ggaccacaat aatttcactg tagatgatat gctaggatca aagttaaaca gcattcttca   2160

ctgcaggaca tctcagagca tgtaacataa ctgcatgatt atatactcta agcaatagag   2220

agcttcatga ctgagtaaga gttttgaagt cagcagtgaa tcaagtgccc acagatttgc   2280

aggcttaagc agaacaaggg aagattgata tttttggata tgctatagca gctttctcct   2340

atgaaataaa actgatgatg tttggaagta tactactctc aaaggtgtct ttaaagtaca   2400

ggttaatggt gaacattttc ccccagtggc ttcacctcat tcctcccact ggccttaccc   2460

cttccttccc cagtggaagc attttcaaaa gcaaagataa ttttcgctgg tgaacttcag   2520

aacttgcctt cagggttagc ttcatgtaat tttaccattt cccatcccca ttccccacca   2580

cattatgtca agattcaagt tataaattaa cgttttactt agactttgaa agagatttca   2640

tgagtaattt gaatgaacct tgctgaatta atctgaatag caactgtctg acttgataac   2700

tccagtgcca gtatagtggc tgctgcatag acactattca gtaaatgtct gatgaaagaa   2760

attggacttt ttccctttaa tactgatgat gcaattttga aatgttgctt gttctggaat   2820

acttcggaag ttaaacaata aagtcagctt ggagaggaga tcatgatctt tatactgtga   2880

atagcagaat gtcacagatg aagaatatta aaattagggg cgtccactcc aaaacatatc   2940

accagagtga caacttcagc cctcagcctc tgcaatccat atatatcctg gtcttgggag   3000

tccatagaat actgtttcct tctaataaag gtttcaaaca aaaaaaaaaa aaaaaaaaaa   3060

aa                                                                  3062


<210>  1284
<211>  325
<212>  PRT
<213>  Homosapiens

<400>  1284

Met Ala Pro Leu Lys Gly Val Gln Glu Gln Gln Val Arg His Glu Cys 
1               5                   10                  15      


Glu Val Thr Lys Pro Glu Lys Glu Lys Gly Glu Glu Thr Arg Ile Glu 
            20                  25                  30          


Asn Gly Lys Leu Ile Val Val Thr Asp Ser Cys Gly Arg Val Glu Ser 
        35                  40                  45              


Ser Gly Lys Ile Ser Glu Pro Met Glu Ala His Asn Glu Gly Ser Asn 
    50                  55                  60                  


Leu Glu Arg His Gln Ala Lys Pro Lys Glu Lys Ile Glu Tyr Lys Cys 
65                  70                  75                  80  


Ser Glu Arg Glu Gln Arg Phe Ile Gln His Leu Asp Leu Ile Glu His 
                85                  90                  95      


Ala Ser Thr His Thr Gly Lys Lys Leu Cys Glu Ser Asp Val Cys Gln 
            100                 105                 110         


Ser Ser Ser Leu Thr Gly His Lys Lys Val Leu Ser Arg Glu Lys Gly 
        115                 120                 125             


His Gln Cys His Glu Cys Gly Lys Ala Phe Gln Arg Ser Ser His Leu 
    130                 135                 140                 


Val Arg His Gln Lys Ile His Leu Gly Glu Lys Pro Tyr Gln Cys Asn 
145                 150                 155                 160 


Glu Cys Gly Lys Val Phe Ser Gln Asn Ala Gly Leu Leu Glu His Leu 
                165                 170                 175     


Arg Ile His Thr Gly Glu Lys Pro Tyr Leu Cys Ile His Cys Gly Lys 
            180                 185                 190         


Asn Phe Arg Arg Ser Ser His Leu Asn Arg His Gln Arg Ile His Ser 
        195                 200                 205             


Gln Glu Glu Pro Cys Glu Cys Lys Glu Cys Gly Lys Thr Phe Ser Gln 
    210                 215                 220                 


Ala Leu Leu Leu Thr His His Gln Arg Ile His Ser His Ser Lys Ser 
225                 230                 235                 240 


His Gln Cys Asn Glu Cys Gly Lys Ala Phe Ser Leu Thr Ser Asp Leu 
                245                 250                 255     


Ile Arg His His Arg Ile His Thr Gly Glu Lys Pro Phe Lys Cys Asn 
            260                 265                 270         


Ile Cys Gln Lys Ala Phe Arg Leu Asn Ser His Leu Ala Gln His Val 
        275                 280                 285             


Arg Ile His Asn Glu Glu Lys Pro Tyr Gln Cys Ser Glu Cys Gly Glu 
    290                 295                 300                 


Ala Phe Arg Gln Arg Ser Gly Leu Phe Gln His Gln Arg Tyr His His 
305                 310                 315                 320 


Lys Asp Lys Leu Ala 
                325 


<210>  1285
<211>  2328
<212>  DNA
<213>  Homosapiens

<400>  1285
agcggagaag aaagcgctcc gaagagctag agctgacact cggcgatgag ctaagacgct     60

gtttcagagc gtttgggtcc tctgaggccc cttgaccagg agtgtctctg aagatacagt    120

ccaaagaaag ttctccaaaa caaggagaac agtctgaagc tggggatggc aacagcattg    180

gacccagacc agccaaagaa acaaaaaata cttgtggagg agatggcccc tctgaaagga    240

gtacaggaac agcaggttcg gcatgagtgt gaagttacaa agcctgagaa agagaagggt    300

gaggagacaa ggattgagaa tgggaagctt attgtagtaa cagactcttg tggaagagta    360

gagtcatctg ggaaaatatc tgaacccatg gaggctcata atgagggctc taacttggaa    420

aggcatcagg ccaagcccaa agagaagatt gagtataaat gctcagaacg tgagcagaga    480

ttcatccagc acttggacct gattgaacat gcgagtacac acacgggaaa gaaactctgc    540

gagtctgatg tgtgtcagag ttccagtctt acaggacata agaaagtcct ctctagagag    600

aaaggtcatc agtgtcatga gtgtgggaaa gcctttcaga ggagttcaca cctcgtcaga    660

catcagaaaa tccatcttgg tgagaagcct tatcagtgca atgagtgtgg caaagtcttt    720

agccagaatg caggcctttt ggaacatctc agaattcata ctggagagaa accttatcta    780

tgtatccatt gtggaaaaaa ttttaggcgc agctctcacc ttaatcgaca tcagagaatt    840

cacagtcagg aggagccctg tgagtgcaag gagtgtggaa aaacctttag tcaggcctta    900

ctcctcaccc accatcagag aatccatagt cactccaaaa gccatcaatg taacgagtgt    960

ggaaaagctt tcagtttgac ctcagacctt attcgacacc acagaattca tactggagaa   1020

aaacctttca agtgtaacat atgccagaaa gccttccgac taaactcaca ccttgctcag   1080

catgtaagaa tccacaatga agaaaaaccc tatcagtgta gtgaatgtgg agaagccttc   1140

aggcaaaggt caggtctttt tcaacatcag agatatcacc acaaagacaa actggcttga   1200

tgaggtgttc tctccttgta gaacatcaga gaaggcacat tgactagcaa acagcacttt   1260

aggaaaagtc accgtagccc actgtggcat cagaaaattc ttgggggctg agttggaggc   1320

tccctgcctc tattctctct cctttgcttt ccttgaagtc agctttggac cacaataatt   1380

tcactgtaga tgatatgcta ggatcaaagt taaacagcat tcttcactgc aggacatctc   1440

agagcatgta acataactgc atgattatat actctaagca atagagagct tcatgactga   1500

gtaagagttt tgaagtcagc agtgaatcaa gtgcccacag atttgcaggc ttaagcagaa   1560

caagggaaga ttgatatttt tggatatgct atagcagctt tctcctatga aataaaactg   1620

atgatgtttg gaagtatact actctcaaag gtgtctttaa agtacaggtt aatggtgaac   1680

attttccccc agtggcttca cctcattcct cccactggcc ttaccccttc cttccccagt   1740

ggaagcattt tcaaaagcaa agataatttt cgctggtgaa cttcagaact tgccttcagg   1800

gttagcttca tgtaatttta ccatttccca tccccattcc ccaccacatt atgtcaagat   1860

tcaagttata aattaacgtt ttacttagac tttgaaagag atttcatgag taatttgaat   1920

gaaccttgct gaattaatct gaatagcaac tgtctgactt gataactcca gtgccagtat   1980

agtggctgct gcatagacac tattcagtaa atgtctgatg aaagaaattg gactttttcc   2040

ctttaatact gatgatgcaa ttttgaaatg ttgcttgttc tggaatactt cggaagttaa   2100

acaataaagt cagcttggag aggagatcat gatctttata ctgtgaatag cagaatgtca   2160

cagatgaaga atattaaaat taggggcgtc cactccaaaa catatcacca gagtgacaac   2220

ttcagccctc agcctctgca atccatatat atcctggtct tgggagtcca tagaatactg   2280

tttccttcta ataaaggttt caaacaaaaa aaaaaaaaaa aaaaaaaa                2328


<210>  1286
<211>  325
<212>  PRT
<213>  Homosapiens

<400>  1286

Met Ala Pro Leu Lys Gly Val Gln Glu Gln Gln Val Arg His Glu Cys 
1               5                   10                  15      


Glu Val Thr Lys Pro Glu Lys Glu Lys Gly Glu Glu Thr Arg Ile Glu 
            20                  25                  30          


Asn Gly Lys Leu Ile Val Val Thr Asp Ser Cys Gly Arg Val Glu Ser 
        35                  40                  45              


Ser Gly Lys Ile Ser Glu Pro Met Glu Ala His Asn Glu Gly Ser Asn 
    50                  55                  60                  


Leu Glu Arg His Gln Ala Lys Pro Lys Glu Lys Ile Glu Tyr Lys Cys 
65                  70                  75                  80  


Ser Glu Arg Glu Gln Arg Phe Ile Gln His Leu Asp Leu Ile Glu His 
                85                  90                  95      


Ala Ser Thr His Thr Gly Lys Lys Leu Cys Glu Ser Asp Val Cys Gln 
            100                 105                 110         


Ser Ser Ser Leu Thr Gly His Lys Lys Val Leu Ser Arg Glu Lys Gly 
        115                 120                 125             


His Gln Cys His Glu Cys Gly Lys Ala Phe Gln Arg Ser Ser His Leu 
    130                 135                 140                 


Val Arg His Gln Lys Ile His Leu Gly Glu Lys Pro Tyr Gln Cys Asn 
145                 150                 155                 160 


Glu Cys Gly Lys Val Phe Ser Gln Asn Ala Gly Leu Leu Glu His Leu 
                165                 170                 175     


Arg Ile His Thr Gly Glu Lys Pro Tyr Leu Cys Ile His Cys Gly Lys 
            180                 185                 190         


Asn Phe Arg Arg Ser Ser His Leu Asn Arg His Gln Arg Ile His Ser 
        195                 200                 205             


Gln Glu Glu Pro Cys Glu Cys Lys Glu Cys Gly Lys Thr Phe Ser Gln 
    210                 215                 220                 


Ala Leu Leu Leu Thr His His Gln Arg Ile His Ser His Ser Lys Ser 
225                 230                 235                 240 


His Gln Cys Asn Glu Cys Gly Lys Ala Phe Ser Leu Thr Ser Asp Leu 
                245                 250                 255     


Ile Arg His His Arg Ile His Thr Gly Glu Lys Pro Phe Lys Cys Asn 
            260                 265                 270         


Ile Cys Gln Lys Ala Phe Arg Leu Asn Ser His Leu Ala Gln His Val 
        275                 280                 285             


Arg Ile His Asn Glu Glu Lys Pro Tyr Gln Cys Ser Glu Cys Gly Glu 
    290                 295                 300                 


Ala Phe Arg Gln Arg Ser Gly Leu Phe Gln His Gln Arg Tyr His His 
305                 310                 315                 320 


Lys Asp Lys Leu Ala 
                325 


<210>  1287
<211>  3082
<212>  DNA
<213>  Homosapiens

<400>  1287
ctggaggcgc cggcagcgcc cgccagaccc gccagcccag cggcccgggc tctggggaaa     60

ccggcgctcc cgacagggga gcaccgggcc tctgagctcc ctcgggagcc tttcacgagg    120

tcagctacgt ctttgttgtg cgcgttcctg aacttttggt ccattaacca acaattagac    180

acgccggtat tcagtgcctg gcgcggtgct agatgctggg tgtaatctca gaaaaataca    240

ttcaggggcg cgcctgaggg tgctggctgc tggcatctca ggtgctttac gtgcattcgt    300

gaagaagccc atcagtattt cttgaatacc agaccccaag ctaagtgaag ctttagcctc    360

taagctcaac atgtatgaag ctttgccagg ccctgctcct gaaaatgaag atggccttgt    420

gaaagtgaag gaggaagatc ccacctggga gcaggtgtgc aactcacagg agggcagctc    480

ccacactcag gagatttgcc gcctgcgctt tcggcacttc tgctaccagg aggctcacgg    540

accccaggaa gctctggccc aactccgaga actttgtcat caatggctga gaccggagat    600

gcacaccaag gaacagataa tggaactgct ggtgctggag cagttcctga ccatcctgcc    660

caaggagctc cagccctgtg tgaagacata tcctctggag agtggagagg aggcagtgac    720

agtgctggag aatctagaga caggaagtgg agacacagga caacaggcct ctgtctatat    780

tcagggacag gacatgcacc caatggtggc agaatatcaa ggagtctctt tggagtgtca    840

gagcctccag ctcctgcctg ggataaccac cctgaagtgt gaacctccac agcgtcctca    900

agggaacccc caagaagtga gtgggcctgt tccccacgga tcagctcatc tccaggaaaa    960

aaaccccaga gacaaggctg tagtgcctgt gtttaaccca gtcaggtccc agacattggt   1020

gaagactgag gaagaaacag cccaggccgt tgctgcagag aagtggtcac atctgagtct   1080

gactcggagg aacctctgtg ggaactcagc tcaggagaca gttatgagcc tcagtccgat   1140

gactgaagaa attgtaacta aagatagatt gtttaaagca aagcaagaaa cttctgaaga   1200

aatggaacaa agtggagaag cctcaggaaa gcccaacaga gagtgtgcac cccagattcc   1260

ttgtagtact cctattgcta ctgaaaggac agttgcacat ttgaacactc tgaaggaccg   1320

tcacccaggt gatttgtggg cccgcatgca catctcatcc ctggaatatg ctgcaggaga   1380

cattacccga aaagggagaa aaaaagacaa agctcgagtg agtgaactgc tccaaggcct   1440

ctcattctct ggtgactcag atgtggaaaa agataatgag cctgagatcc agcctgctca   1500

aaagaagtta aaggtatcat gtttcccaga aaagagttgg accaaaagag acattaaacc   1560

caattttcca agctggtcag cactggattc tggacttttg aatctcaaga gcgaaaagtt   1620

gaacccagta gagctttttg aattattttt tgatgatgaa acattcaact taattgtcaa   1680

tgaaaccaat aattatgctt ctcagaaaaa tgtcagcttg gaagtcacag ttcaggaaat   1740

gaggtgtgtg tttggtgtct tacttttgag tggatttatg aggcatccta gaagggaaat   1800

gtattgggaa gtctctgaca ccgatcagaa cctggttaga gatgcaatca gaagggacag   1860

atttgaattg attttctcaa acctgcactt tgcagataat ggccacctag atcaaaaaga   1920

taagtttaca aagttgagac ctctcataaa acaaatgaat aaaaatttcc tcttgtatgc   1980

tcccctggaa gaatactatt gctttgataa gtcaatgtgt gaatgctttg atagtgacca   2040

attcctgaat ggaaagccta ttagaattgg ctataaaatt tggtgtggta caaccacaca   2100

gggttatctg gtttggtttg aaccctatca agaagaatca actatgaagg tagatgagga   2160

tcctgatctt gggttaggtg gaaatctagt gatgaacttc gctgatgttc ttttagagag   2220

aggtcagtat ccctatcacc tgtgttttga tagcttcttt acaagtgtca aattgttgtc   2280

agccttgaaa aagaaggggg tgagggcaac aggaacaatt cgtgagaaca ggaccgaaaa   2340

atgtcccctt atgaatgtag aacatatgaa aaaaatgaag agagggtatt ttgatttccg   2400

aatagaagaa aacaatgaga taattttgtg tcgttggtat ggggatggca ttatcagtct   2460

gtgctccaat gctgtgggca tagaaccagt caatgaggta agctgttgtg atgctgataa   2520

cgaagaaatc cctcagataa gtcaaccatc catagtaaaa gtgtatgatg aatgcaagga   2580

aggtgtagct aaaatggatc aaattatttc gaaatacagg gtgaggataa gaagcaagaa   2640

atggtactca attttggtga gctacatgat tgatgtagcc atgaacaatg catggcaact   2700

acacagagcc tgtaacccag gtgcttctct agaccccttg gattttcgga gatttgttgc   2760

acatttctac ttggaacaca atgctcatct gtcagattag ggtacataaa atggacatag   2820

tgcagacatt aataagacat agaaaaataa taattataca tgctgttgta ccctcccaaa   2880

gtaaatctga tatatgtaat gaagttatta aataatactt ttaaaaatca gacatttata   2940

tagagtttca aagactattg taacaagtaa tgttaaaaat tgtctgtgag aatgttgaac   3000

tgtagtacct ttctctatgt caagttttgt gtcagacatg ggaaatcatg tatttgttca   3060

attgaaaaaa aaaaaaaaaa aa                                            3082


<210>  1288
<211>  809
<212>  PRT
<213>  Homosapiens

<400>  1288

Met Tyr Glu Ala Leu Pro Gly Pro Ala Pro Glu Asn Glu Asp Gly Leu 
1               5                   10                  15      


Val Lys Val Lys Glu Glu Asp Pro Thr Trp Glu Gln Val Cys Asn Ser 
            20                  25                  30          


Gln Glu Gly Ser Ser His Thr Gln Glu Ile Cys Arg Leu Arg Phe Arg 
        35                  40                  45              


His Phe Cys Tyr Gln Glu Ala His Gly Pro Gln Glu Ala Leu Ala Gln 
    50                  55                  60                  


Leu Arg Glu Leu Cys His Gln Trp Leu Arg Pro Glu Met His Thr Lys 
65                  70                  75                  80  


Glu Gln Ile Met Glu Leu Leu Val Leu Glu Gln Phe Leu Thr Ile Leu 
                85                  90                  95      


Pro Lys Glu Leu Gln Pro Cys Val Lys Thr Tyr Pro Leu Glu Ser Gly 
            100                 105                 110         


Glu Glu Ala Val Thr Val Leu Glu Asn Leu Glu Thr Gly Ser Gly Asp 
        115                 120                 125             


Thr Gly Gln Gln Ala Ser Val Tyr Ile Gln Gly Gln Asp Met His Pro 
    130                 135                 140                 


Met Val Ala Glu Tyr Gln Gly Val Ser Leu Glu Cys Gln Ser Leu Gln 
145                 150                 155                 160 


Leu Leu Pro Gly Ile Thr Thr Leu Lys Cys Glu Pro Pro Gln Arg Pro 
                165                 170                 175     


Gln Gly Asn Pro Gln Glu Val Ser Gly Pro Val Pro His Gly Ser Ala 
            180                 185                 190         


His Leu Gln Glu Lys Asn Pro Arg Asp Lys Ala Val Val Pro Val Phe 
        195                 200                 205             


Asn Pro Val Arg Ser Gln Thr Leu Val Lys Thr Glu Glu Glu Thr Ala 
    210                 215                 220                 


Gln Ala Val Ala Ala Glu Lys Trp Ser His Leu Ser Leu Thr Arg Arg 
225                 230                 235                 240 


Asn Leu Cys Gly Asn Ser Ala Gln Glu Thr Val Met Ser Leu Ser Pro 
                245                 250                 255     


Met Thr Glu Glu Ile Val Thr Lys Asp Arg Leu Phe Lys Ala Lys Gln 
            260                 265                 270         


Glu Thr Ser Glu Glu Met Glu Gln Ser Gly Glu Ala Ser Gly Lys Pro 
        275                 280                 285             


Asn Arg Glu Cys Ala Pro Gln Ile Pro Cys Ser Thr Pro Ile Ala Thr 
    290                 295                 300                 


Glu Arg Thr Val Ala His Leu Asn Thr Leu Lys Asp Arg His Pro Gly 
305                 310                 315                 320 


Asp Leu Trp Ala Arg Met His Ile Ser Ser Leu Glu Tyr Ala Ala Gly 
                325                 330                 335     


Asp Ile Thr Arg Lys Gly Arg Lys Lys Asp Lys Ala Arg Val Ser Glu 
            340                 345                 350         


Leu Leu Gln Gly Leu Ser Phe Ser Gly Asp Ser Asp Val Glu Lys Asp 
        355                 360                 365             


Asn Glu Pro Glu Ile Gln Pro Ala Gln Lys Lys Leu Lys Val Ser Cys 
    370                 375                 380                 


Phe Pro Glu Lys Ser Trp Thr Lys Arg Asp Ile Lys Pro Asn Phe Pro 
385                 390                 395                 400 


Ser Trp Ser Ala Leu Asp Ser Gly Leu Leu Asn Leu Lys Ser Glu Lys 
                405                 410                 415     


Leu Asn Pro Val Glu Leu Phe Glu Leu Phe Phe Asp Asp Glu Thr Phe 
            420                 425                 430         


Asn Leu Ile Val Asn Glu Thr Asn Asn Tyr Ala Ser Gln Lys Asn Val 
        435                 440                 445             


Ser Leu Glu Val Thr Val Gln Glu Met Arg Cys Val Phe Gly Val Leu 
    450                 455                 460                 


Leu Leu Ser Gly Phe Met Arg His Pro Arg Arg Glu Met Tyr Trp Glu 
465                 470                 475                 480 


Val Ser Asp Thr Asp Gln Asn Leu Val Arg Asp Ala Ile Arg Arg Asp 
                485                 490                 495     


Arg Phe Glu Leu Ile Phe Ser Asn Leu His Phe Ala Asp Asn Gly His 
            500                 505                 510         


Leu Asp Gln Lys Asp Lys Phe Thr Lys Leu Arg Pro Leu Ile Lys Gln 
        515                 520                 525             


Met Asn Lys Asn Phe Leu Leu Tyr Ala Pro Leu Glu Glu Tyr Tyr Cys 
    530                 535                 540                 


Phe Asp Lys Ser Met Cys Glu Cys Phe Asp Ser Asp Gln Phe Leu Asn 
545                 550                 555                 560 


Gly Lys Pro Ile Arg Ile Gly Tyr Lys Ile Trp Cys Gly Thr Thr Thr 
                565                 570                 575     


Gln Gly Tyr Leu Val Trp Phe Glu Pro Tyr Gln Glu Glu Ser Thr Met 
            580                 585                 590         


Lys Val Asp Glu Asp Pro Asp Leu Gly Leu Gly Gly Asn Leu Val Met 
        595                 600                 605             


Asn Phe Ala Asp Val Leu Leu Glu Arg Gly Gln Tyr Pro Tyr His Leu 
    610                 615                 620                 


Cys Phe Asp Ser Phe Phe Thr Ser Val Lys Leu Leu Ser Ala Leu Lys 
625                 630                 635                 640 


Lys Lys Gly Val Arg Ala Thr Gly Thr Ile Arg Glu Asn Arg Thr Glu 
                645                 650                 655     


Lys Cys Pro Leu Met Asn Val Glu His Met Lys Lys Met Lys Arg Gly 
            660                 665                 670         


Tyr Phe Asp Phe Arg Ile Glu Glu Asn Asn Glu Ile Ile Leu Cys Arg 
        675                 680                 685             


Trp Tyr Gly Asp Gly Ile Ile Ser Leu Cys Ser Asn Ala Val Gly Ile 
    690                 695                 700                 


Glu Pro Val Asn Glu Val Ser Cys Cys Asp Ala Asp Asn Glu Glu Ile 
705                 710                 715                 720 


Pro Gln Ile Ser Gln Pro Ser Ile Val Lys Val Tyr Asp Glu Cys Lys 
                725                 730                 735     


Glu Gly Val Ala Lys Met Asp Gln Ile Ile Ser Lys Tyr Arg Val Arg 
            740                 745                 750         


Ile Arg Ser Lys Lys Trp Tyr Ser Ile Leu Val Ser Tyr Met Ile Asp 
        755                 760                 765             


Val Ala Met Asn Asn Ala Trp Gln Leu His Arg Ala Cys Asn Pro Gly 
    770                 775                 780                 


Ala Ser Leu Asp Pro Leu Asp Phe Arg Arg Phe Val Ala His Phe Tyr 
785                 790                 795                 800 


Leu Glu His Asn Ala His Leu Ser Asp 
                805                 


<210>  1289
<211>  2628
<212>  DNA
<213>  Homosapiens

<400>  1289
ggcggttgat cggtcattgg ggtgctgcag ccccgccacc tgttccgtag cttgccggtg     60

ccccgaaggt gtcttctcct aaggaagatt aaatcagaaa attttaaatc acagttatcc    120

ctttacttaa agccagagta agccttccaa attaacccca ggaatggctt caacagagga    180

acagtacgat cttaagattg tgaaagtgga ggaagaccct atctgggacc aagaaaccca    240

ccttcgaggg aacaactttt ctggccaaga agcctcccga caacttttta ggcagttttg    300

ttaccaagag actcctggtc cccgagaagc tctgagccgg ctccgagaac tctgtcatca    360

gtggctaagg ccagaaatcc acaccaaaga gcaaatcttg gagctgctgg tgctggagca    420

attcctgact atcctgcctg aggagctcca ggcctgggtg cgggagcacc atccggagag    480

tggggaggag gctgtggctg tagttgaaga tctggaacaa gagcttagtg agccagggaa    540

ccaggctcca gaccatgaac atggacattc tgaagtgctc ttggaggatg tggaacatct    600

gaaggtcaag caggaaccaa cagacataca gcttcagcct atggtgacac agctcagata    660

tgaatctttt tgcctccacc aatttcaaga acaagatggt gaaagtatac ctgagaacca    720

ggagttggca tcaaagcaag aaatcttaaa agaaatggaa catttggggg atagcaaact    780

ccaaagagat gtatctttgg attctaagta cagagaaact tgtaaacgag acagcaaggc    840

agaaaagcag caggcacatt ccactggaga gagacgccac aggtgcaatg aatgtgggaa    900

aagcttcact aagagttcag tactcattga gcaccagaga atccacactg gggagaagcc    960

atatgaatgt gaagaatgtg ggaaggcctt cagccggagg tcaagcctga atgaacatcg   1020

gcggagccac actggagaga aaccctatca atgtaaggag tgtgggaaag ccttcagtgc   1080

cagcaatggc ctcactcgac acagaagaat ccacacaggg gaaaaaccat atgaatgcaa   1140

agtgtgtggg aaggctttcc tcctcagctc atgccttgtt cagcatcaga ggatacacac   1200

tggagagaag cgctatcagt gtcgtgagtg tggcaaagcc ttcattcaga atgcagggct   1260

tttccagcat ctccgagtcc acactggtga gaaaccctat cagtgcagtc agtgcagtaa   1320

actctttagt aagcggacac ttcttaagaa acatcagaaa atccacactg gagagagacc   1380

ataagggtga tgagtttggg aaagccttca gtcatcattg caaccttatt aggcatttta   1440

gaatccatac tgttccagca gaactggact aattctgtgg accctcagac ccctaaatgg   1500

ggccgtcttg gaaagtaaga ttttcaagtg gcttattctg ttcttataaa atttattttg   1560

tattgcattg aaccacttgt ctacaaacca ggtgttggtg tctcctgtgt ggatgactgt   1620

gattgtaggg ggttgctggg tggccttctt attccctagc ctttggtcca tttcttatga   1680

tttcctttaa aggcaccaaa tcttatctgg aaataaattg ttatggaggg gctgtttttg   1740

agcaatactg catattgaac aattctaaaa gaccagtatc tatgtatact tttaaaaaaa   1800

agatttgcta agatcaaagg atattcagag gtgcatcttt ttctgtaaga gtgacatttt   1860

aaacaaatgt aaggttttgg ggaataagaa tcgtccacat tcccacagga aatcattgct   1920

atggtctccc ctaggaatgt gatagatagc ttctataatt atgcagcatt atccatagta   1980

tgaaacctgt agttttaatg gtttagaaat ctatgtctca tttcatatct aactcatgtt   2040

tttgatacga atcaatatat atgttgatat catgagttaa tatgagtttg acatgaatca   2100

tcaacatagt atatacatat caacataact atgttgatga ttcatatcaa attctcaatg   2160

caggtcatta ctgtaagttt tccatttttg ttacaaataa taagtaagat gatactttaa   2220

aatctctgtt cttcacaagg tacctcttta attcatagcc ttttatgtca gcattattct   2280

tcttttgggg gttggtcagc aactttgagt gccattgcaa gcagcatcat ttaagtagtt   2340

ttataaagaa aagaagtctg atatcttggg cagcttgctg cttactgggg agaccagcat   2400

gcttagacac ttattgccag ggttaaacat atgctctggc accaagttca aatctttcct   2460

ccccatttgt gagctgtggg actttaggca agttatctaa atgctgctat gctatagtct   2520

ccccacctgt aaaacagagg atgataccaa taccttcctc atagggtaca taagattaaa   2580

taaatacaaa cttgtaccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                2628


<210>  1290
<211>  209
<212>  PRT
<213>  Homosapiens

<400>  1290

Met Glu His Leu Gly Asp Ser Lys Leu Gln Arg Asp Val Ser Leu Asp 
1               5                   10                  15      


Ser Lys Tyr Arg Glu Thr Cys Lys Arg Asp Ser Lys Ala Glu Lys Gln 
            20                  25                  30          


Gln Ala His Ser Thr Gly Glu Arg Arg His Arg Cys Asn Glu Cys Gly 
        35                  40                  45              


Lys Ser Phe Thr Lys Ser Ser Val Leu Ile Glu His Gln Arg Ile His 
    50                  55                  60                  


Thr Gly Glu Lys Pro Tyr Glu Cys Glu Glu Cys Gly Lys Ala Phe Ser 
65                  70                  75                  80  


Arg Arg Ser Ser Leu Asn Glu His Arg Arg Ser His Thr Gly Glu Lys 
                85                  90                  95      


Pro Tyr Gln Cys Lys Glu Cys Gly Lys Ala Phe Ser Ala Ser Asn Gly 
            100                 105                 110         


Leu Thr Arg His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
        115                 120                 125             


Lys Val Cys Gly Lys Ala Phe Leu Leu Ser Ser Cys Leu Val Gln His 
    130                 135                 140                 


Gln Arg Ile His Thr Gly Glu Lys Arg Tyr Gln Cys Arg Glu Cys Gly 
145                 150                 155                 160 


Lys Ala Phe Ile Gln Asn Ala Gly Leu Phe Gln His Leu Arg Val His 
                165                 170                 175     


Thr Gly Glu Lys Pro Tyr Gln Cys Ser Gln Cys Ser Lys Leu Phe Ser 
            180                 185                 190         


Lys Arg Thr Leu Leu Lys Lys His Gln Lys Ile His Thr Gly Glu Arg 
        195                 200                 205             


Pro 
    


<210>  1291
<211>  3179
<212>  DNA
<213>  Homosapiens

<400>  1291
cagagagaga gagaaaaact gctgaccctg taagagagaa ctggccatct tgcagacaga     60

cagagccccg agtgttcttt caactacctg ccacccatcc aacaactccc ctcggacctc    120

agtatgggct ggaacctgac acttggcatg acagtgaccc caggcatcca aaccatgaca    180

gttccatcag ctctccaaat gagagacaga gtctcactat gtcgcccagg cttgtcttga    240

actcctggac tcaagagatc ctcccatctc ggcctctcaa agtgttggga ttacaggcgt    300

gagctattac acctgactta agtctccatt ttcatatcta tactttggga ttccagaaga    360

cagaggtttg agtgtaaaac acaaaataac aaaaccacaa caaaaacaac tctgtattct    420

cgtccccacc attaccatct ctcctttgtg atgtcaaaga gaccagagga agtggacaga    480

ctcggggaag aatagccaga gtaagccttc caaattaacc ccaggaatgg cttcaacaga    540

ggaacagtac gatcttaaga ttgtgaaagt ggaggaagac cctatctggg accaagaaac    600

ccaccttcga gggaacaact tttctggcca agaagcctcc cgacaacttt ttaggcagtt    660

ttgttaccaa gagactcctg gtccccgaga agctctgagc cggctccgag aactctgtca    720

tcagtggcta aggccagaaa tccacaccaa agagcaaatc ttggagctgc tggtgctgga    780

gcaattcctg actatcctgc ctgaggagct ccaggcctgg gtgcgggagc accatccgga    840

gagtggggag gaggctgtgg ctgtagttga agatctggaa caagagctta gtgagccagg    900

gaaccaggct ccagaccatg aacatggaca ttctgaagtg ctcttggagg atgtggaaca    960

tctgaaggtc aagcaggaac caacagacat acagcttcag cctatggtga cacagctcag   1020

atatgaatct ttttgcctcc accaatttca agaacaagat ggtgaaagta tacctgagaa   1080

ccaggagttg gcatcaaagc aagaaatctt aaaagaaatg gaacatttgg gggatagcaa   1140

actccaaaga gatgtatctt tggattctaa gtacagagaa acttgtaaac gagacagcaa   1200

ggcagaaaag cagcaggcac attccactgg agagagacgc cacaggtgca atgaatgtgg   1260

gaaaagcttc actaagagtt cagtactcat tgagcaccag agaatccaca ctggggagaa   1320

gccatatgaa tgtgaagaat gtgggaaggc cttcagccgg aggtcaagcc tgaatgaaca   1380

tcggcggagc cacactggag agaaacccta tcaatgtaag gagtgtggga aagccttcag   1440

tgccagcaat ggcctcactc gacacagaag aatccacaca ggggaaaaac catatgaatg   1500

caaagtgtgt gggaaggctt tcctcctcag ctcatgcctt gttcagcatc agaggataca   1560

cactggagag aagcgctatc agtgtcgtga gtgtggcaaa gccttcattc agaatgcagg   1620

gcttttccag catctccgag tccacactgg tgagaaaccc tatcagtgca gtcagtgcag   1680

taaactcttt agtaagcgga cacttcttaa gaaacatcag aaaatccaca ctggagagag   1740

accataaggg tgatgagttt gggaaagcct tcagtcatca ttgcaacctt attaggcatt   1800

ttagaatcca tactgttcca gcagaactgg actaattctg tggaccctca gacccctaaa   1860

tggggccgtc ttggaaagta agattttcaa gtggcttatt ctgttcttat aaaatttatt   1920

ttgtattgca ttgaaccact tgtctacaaa ccaggtgttg gtgtctcctg tgtggatgac   1980

tgtgattgta gggggttgct gggtggcctt cttattccct agcctttggt ccatttctta   2040

tgatttcctt taaaggcacc aaatcttatc tggaaataaa ttgttatgga ggggctgttt   2100

ttgagcaata ctgcatattg aacaattcta aaagaccagt atctatgtat acttttaaaa   2160

aaaagatttg ctaagatcaa aggatattca gaggtgcatc tttttctgta agagtgacat   2220

tttaaacaaa tgtaaggttt tggggaataa gaatcgtcca cattcccaca ggaaatcatt   2280

gctatggtct cccctaggaa tgtgatagat agcttctata attatgcagc attatccata   2340

gtatgaaacc tgtagtttta atggtttaga aatctatgtc tcatttcata tctaactcat   2400

gtttttgata cgaatcaata tatatgttga tatcatgagt taatatgagt ttgacatgaa   2460

tcatcaacat agtatataca tatcaacata actatgttga tgattcatat caaattctca   2520

atgcaggtca ttactgtaag ttttccattt ttgttacaaa taataagtaa gatgatactt   2580

taaaatctct gttcttcaca aggtacctct ttaattcata gccttttatg tcagcattat   2640

tcttcttttg ggggttggtc agcaactttg agtgccattg caagcagcat catttaagta   2700

gttttataaa gaaaagaagt ctgatatctt gggcagcttg ctgcttactg gggagaccag   2760

catgcttaga cacttattgc cagggttaaa catatgctct ggcaccaagt tcaaatcttt   2820

cctccccatt tgtgagctgt gggactttag gcaagttatc taaatgctgc tatgctatag   2880

tctccccacc tgtaaaacag aggatgatac caataccttc ctcatagggt acataagatt   2940

aaataaatac aaacttgtac ttaaaatgta gctctcaata aatatgcatt atgatttaca   3000

tacgaaataa tagcatttaa caaatgtagg tagaatttta agtatcatgt taaaattagg   3060

atacgaaatg cctctgctga cattcttgtt actcttttct ccacagtcaa aacctgaatc   3120

agaatatttc aaaagagagg aaataaaagt tcagcttaaa actgttctgc cctaaaaaa    3179


<210>  1292
<211>  406
<212>  PRT
<213>  Homosapiens

<400>  1292

Met Ala Ser Thr Glu Glu Gln Tyr Asp Leu Lys Ile Val Lys Val Glu 
1               5                   10                  15      


Glu Asp Pro Ile Trp Asp Gln Glu Thr His Leu Arg Gly Asn Asn Phe 
            20                  25                  30          


Ser Gly Gln Glu Ala Ser Arg Gln Leu Phe Arg Gln Phe Cys Tyr Gln 
        35                  40                  45              


Glu Thr Pro Gly Pro Arg Glu Ala Leu Ser Arg Leu Arg Glu Leu Cys 
    50                  55                  60                  


His Gln Trp Leu Arg Pro Glu Ile His Thr Lys Glu Gln Ile Leu Glu 
65                  70                  75                  80  


Leu Leu Val Leu Glu Gln Phe Leu Thr Ile Leu Pro Glu Glu Leu Gln 
                85                  90                  95      


Ala Trp Val Arg Glu His His Pro Glu Ser Gly Glu Glu Ala Val Ala 
            100                 105                 110         


Val Val Glu Asp Leu Glu Gln Glu Leu Ser Glu Pro Gly Asn Gln Ala 
        115                 120                 125             


Pro Asp His Glu His Gly His Ser Glu Val Leu Leu Glu Asp Val Glu 
    130                 135                 140                 


His Leu Lys Val Lys Gln Glu Pro Thr Asp Ile Gln Leu Gln Pro Met 
145                 150                 155                 160 


Val Thr Gln Leu Arg Tyr Glu Ser Phe Cys Leu His Gln Phe Gln Glu 
                165                 170                 175     


Gln Asp Gly Glu Ser Ile Pro Glu Asn Gln Glu Leu Ala Ser Lys Gln 
            180                 185                 190         


Glu Ile Leu Lys Glu Met Glu His Leu Gly Asp Ser Lys Leu Gln Arg 
        195                 200                 205             


Asp Val Ser Leu Asp Ser Lys Tyr Arg Glu Thr Cys Lys Arg Asp Ser 
    210                 215                 220                 


Lys Ala Glu Lys Gln Gln Ala His Ser Thr Gly Glu Arg Arg His Arg 
225                 230                 235                 240 


Cys Asn Glu Cys Gly Lys Ser Phe Thr Lys Ser Ser Val Leu Ile Glu 
                245                 250                 255     


His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Glu Glu Cys 
            260                 265                 270         


Gly Lys Ala Phe Ser Arg Arg Ser Ser Leu Asn Glu His Arg Arg Ser 
        275                 280                 285             


His Thr Gly Glu Lys Pro Tyr Gln Cys Lys Glu Cys Gly Lys Ala Phe 
    290                 295                 300                 


Ser Ala Ser Asn Gly Leu Thr Arg His Arg Arg Ile His Thr Gly Glu 
305                 310                 315                 320 


Lys Pro Tyr Glu Cys Lys Val Cys Gly Lys Ala Phe Leu Leu Ser Ser 
                325                 330                 335     


Cys Leu Val Gln His Gln Arg Ile His Thr Gly Glu Lys Arg Tyr Gln 
            340                 345                 350         


Cys Arg Glu Cys Gly Lys Ala Phe Ile Gln Asn Ala Gly Leu Phe Gln 
        355                 360                 365             


His Leu Arg Val His Thr Gly Glu Lys Pro Tyr Gln Cys Ser Gln Cys 
    370                 375                 380                 


Ser Lys Leu Phe Ser Lys Arg Thr Leu Leu Lys Lys His Gln Lys Ile 
385                 390                 395                 400 


His Thr Gly Glu Arg Pro 
                405     


<210>  1293
<211>  2242
<212>  DNA
<213>  Homosapiens

<400>  1293
cggcgtcggc cttccactgt ggggttaaat ctcatcccgc ggctctcctc ctgtcggtcc     60

tgcagttctt ttgtccccgg gtagagggat cttctgcaga aatagcgctg gaagctagag    120

tgaggcctga gtactgcctt ggcctaggat ggctagagaa ttaagtgaaa gcacagccct    180

ggatgcccag tctacagaag accagatgga gcttctggtc ataaaggtgg aggaagaaga    240

agccggtttt cccagtagcc cagatctggg ttctgagggc tcccgcgagc gcttccgagg    300

cttccgctac ccggaggctg caggcccccg cgaggcgctg agtcggctcc gagagctctg    360

ccgacagtgg ctgcagcctg agatgcacag caaggagcag atcctggagc tgctggtgct    420

ggagcagttc ctgaccatcc tgccggggaa tctgcagagc tgggtgcggg agcagcatcc    480

agagagcggg gaggaggtgg tggtgctatt ggagtatttg gagaggcagc tggatgagcc    540

ggcgccgcag gtttcaggtg ttgaccaggg gcaagaactg ctctgttgca agatggcact    600

attgacacca gccccagggt cacaaagtag ccaatttcag ctaatgaagg ctctgctcaa    660

gcatgaatct gtgggatccc agcctttaca agatagagtt ctccaggtcc ccatgcttgc    720

ccatggagga tgctgcagag aagatgcagt ggtagcttct aggcttactc cagagtccca    780

ggggttgttg aaagtggaag atgtggccct gaccctcacc cctgaatgga cacagcagga    840

ttcatctcag gggaatctct gtagagatga aaagcaggag aaccatggca gcctggtctc    900

cctgggtgat gaaaaacaga ctaagagcag ggacttgcct ccagctgagg agcttccaga    960

aaaggagcat gggaagatat cgtgccacct gagagaagac attgcccaga ttcctacatg   1020

tgcagaagct ggtgaacagg agggcaggct acaaagaaag cagaaaaatg ccacaggagg   1080

gaggcggcac atctgccatg aatgtggaaa gagttttgct caaagctcag gcctgagtaa   1140

acacaggaga atccacactg gtgagaaacc ctacgaatgt gaagagtgtg gcaaagcctt   1200

cattgggagc tctgcccttg tcattcatca gagagtccac actggtgaga agccatatga   1260

gtgtgaagaa tgtggtaagg ccttcagtca tagctcagac cttatcaagc atcagagaac   1320

ccacactggg gagaagccct atgagtgtga tgactgtggg aagaccttca gccagagctg   1380

cagcctcctt gaacatcaca gaatccacac tggggagaag ccgtatcagt gcagtatgtg   1440

tggcaaagcc tttaggcgaa gttcacatct cctgagacat cagaggatcc atactgggga   1500

taaaaatgtt caggaacctg agcagggaga ggcctggaaa agtaggatgg aaagccagtt   1560

ggaaaatgtt gaaactccca tgtcttataa atgtaatgag tgtgaaagaa gtttcactca   1620

gaatacaggc ctcattgaac atcaaaaaat ccacactggt gagaaaccct atcagtgtaa   1680

tgcgtgtgga aaaggcttca cccgaatttc ataccttgtt caacatcaga gaagccatgt   1740

agggaaaaac atcctatcac agtgacccat gccatacatg ccagttggtg ctcatttgtc   1800

actgatctga agccactccc cctggagtct caactataga aattgtgggc tgggctttat   1860

ttaccactac acattatcag gtgttagaaa atgtagactg ggttagacaa attatcttct   1920

aagttctaga aggggtttgt aatcaaaaca tatttgatag gaggctacgg gagagttgtc   1980

tagaagaggt aagacctgaa actgtttgtt ctctcccact agaattaaat ggatgtttag   2040

actggctact tgccctaaac cagcacttgg tgatgtctac tgggtggatg gttgtgattt   2100

gggggctgct tctctgacca ttctttttga ctgtaatgaa tcctccacag ttggtcagat   2160

tcataaagtc ttatatcccc ctctgtgcct tttctgcagg tgctaataaa tgtttattga   2220

atgtaaaaaa aaaaaaaaaa aa                                            2242


<210>  1294
<211>  538
<212>  PRT
<213>  Homosapiens

<400>  1294

Met Ala Arg Glu Leu Ser Glu Ser Thr Ala Leu Asp Ala Gln Ser Thr 
1               5                   10                  15      


Glu Asp Gln Met Glu Leu Leu Val Ile Lys Val Glu Glu Glu Glu Ala 
            20                  25                  30          


Gly Phe Pro Ser Ser Pro Asp Leu Gly Ser Glu Gly Ser Arg Glu Arg 
        35                  40                  45              


Phe Arg Gly Phe Arg Tyr Pro Glu Ala Ala Gly Pro Arg Glu Ala Leu 
    50                  55                  60                  


Ser Arg Leu Arg Glu Leu Cys Arg Gln Trp Leu Gln Pro Glu Met His 
65                  70                  75                  80  


Ser Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu Gln Phe Leu Thr 
                85                  90                  95      


Ile Leu Pro Gly Asn Leu Gln Ser Trp Val Arg Glu Gln His Pro Glu 
            100                 105                 110         


Ser Gly Glu Glu Val Val Val Leu Leu Glu Tyr Leu Glu Arg Gln Leu 
        115                 120                 125             


Asp Glu Pro Ala Pro Gln Val Ser Gly Val Asp Gln Gly Gln Glu Leu 
    130                 135                 140                 


Leu Cys Cys Lys Met Ala Leu Leu Thr Pro Ala Pro Gly Ser Gln Ser 
145                 150                 155                 160 


Ser Gln Phe Gln Leu Met Lys Ala Leu Leu Lys His Glu Ser Val Gly 
                165                 170                 175     


Ser Gln Pro Leu Gln Asp Arg Val Leu Gln Val Pro Met Leu Ala His 
            180                 185                 190         


Gly Gly Cys Cys Arg Glu Asp Ala Val Val Ala Ser Arg Leu Thr Pro 
        195                 200                 205             


Glu Ser Gln Gly Leu Leu Lys Val Glu Asp Val Ala Leu Thr Leu Thr 
    210                 215                 220                 


Pro Glu Trp Thr Gln Gln Asp Ser Ser Gln Gly Asn Leu Cys Arg Asp 
225                 230                 235                 240 


Glu Lys Gln Glu Asn His Gly Ser Leu Val Ser Leu Gly Asp Glu Lys 
                245                 250                 255     


Gln Thr Lys Ser Arg Asp Leu Pro Pro Ala Glu Glu Leu Pro Glu Lys 
            260                 265                 270         


Glu His Gly Lys Ile Ser Cys His Leu Arg Glu Asp Ile Ala Gln Ile 
        275                 280                 285             


Pro Thr Cys Ala Glu Ala Gly Glu Gln Glu Gly Arg Leu Gln Arg Lys 
    290                 295                 300                 


Gln Lys Asn Ala Thr Gly Gly Arg Arg His Ile Cys His Glu Cys Gly 
305                 310                 315                 320 


Lys Ser Phe Ala Gln Ser Ser Gly Leu Ser Lys His Arg Arg Ile His 
                325                 330                 335     


Thr Gly Glu Lys Pro Tyr Glu Cys Glu Glu Cys Gly Lys Ala Phe Ile 
            340                 345                 350         


Gly Ser Ser Ala Leu Val Ile His Gln Arg Val His Thr Gly Glu Lys 
        355                 360                 365             


Pro Tyr Glu Cys Glu Glu Cys Gly Lys Ala Phe Ser His Ser Ser Asp 
    370                 375                 380                 


Leu Ile Lys His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


Asp Asp Cys Gly Lys Thr Phe Ser Gln Ser Cys Ser Leu Leu Glu His 
                405                 410                 415     


His Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Ser Met Cys Gly 
            420                 425                 430         


Lys Ala Phe Arg Arg Ser Ser His Leu Leu Arg His Gln Arg Ile His 
        435                 440                 445             


Thr Gly Asp Lys Asn Val Gln Glu Pro Glu Gln Gly Glu Ala Trp Lys 
    450                 455                 460                 


Ser Arg Met Glu Ser Gln Leu Glu Asn Val Glu Thr Pro Met Ser Tyr 
465                 470                 475                 480 


Lys Cys Asn Glu Cys Glu Arg Ser Phe Thr Gln Asn Thr Gly Leu Ile 
                485                 490                 495     


Glu His Gln Lys Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Asn Ala 
            500                 505                 510         


Cys Gly Lys Gly Phe Thr Arg Ile Ser Tyr Leu Val Gln His Gln Arg 
        515                 520                 525             


Ser His Val Gly Lys Asn Ile Leu Ser Gln 
    530                 535             


<210>  1295
<211>  3931
<212>  DNA
<213>  Homosapiens

<400>  1295
gggtcccaaa agggttcgag gcctcttgcc ttcgctccgt aggagggagt tctcttctgg     60

ccctgggggc cgcaggactg tccaggaata cagtttccag gtgagatctt acttgaaaca    120

ccggtagttc tagcacagct aaaatggcat ctacttgggc tatccaggcc cacatggacc    180

aggatgaacc tttggaagta aagatagagg aagagaaata taccaccaga caggattggg    240

acctgcgtaa aaacaacacc catagcagag aggtcttccg tcagtacttc agacagttct    300

gctaccagga gacatctggt ccccgtgagg ctttgagccg actccgagaa ctttgccatc    360

agtggctgag gccagagacc cacaccaaag aacagattct ggagctgctg gtgctggagc    420

agttcctgac catcctacct gaggagctcc aggcctgggt gcaggagcag catccagaga    480

gtggggagga ggtggtgact gtgctggagg atttagagag agaactggat gaaccaggag    540

agcaggtctc agtccacact ggggaacagg aaatgttctt gcaggagacg gtacgtctac    600

gaaaagaagg agaacccagt atgtccctcc agtccatgaa agcccagcca aagtatgaat    660

ctccagaact tgaatcccaa caggagcaag ttttagatgt tgagactgga aatgagtatg    720

ggaatttaaa gcaagaagtt tctgaagaaa tggaaccaca tgggaagaca tccagtaaat    780

ttgaaaatga tatgtccaag tctgctaggt gtggagaaac tcgtgaacct gaagaaataa    840

cagaagagcc ctctgcttgc tccagagaag ataaacaacc tacctgtgat gaaaatggag    900

taagcctgac tgagaactct gaccatactg aacatcagag aatctgtcca ggagaagaat    960

cttacggatg tgatgactgt ggaaaagctt ttagtcagca ctcacacctc atagaacatc   1020

agaggatcca tactggagat agaccctaca aatgcgaaga atgtggaaaa gctttccgtg   1080

ggagaactgt gcttattcga cacaaaataa tacacactgg agagaaaccg tataagtgta   1140

atgaatgtgg caaagccttt ggccggtggt cagctcttaa ccaacatcag agacttcaca   1200

caggagaaaa acactatcac tgtaatgact gtggcaaagc ctttagtcag aaagcaggcc   1260

tctttcacca tatcaagatc cacacaagag acaaacctta tcagtgcact cagtgtaata   1320

aaagttttag tcggcgttcc atacttactc agcatcaagg agttcatacc ggcgccaagc   1380

cgtatgagtg caacgagtgt ggaaaagcct ttgtttataa ctcatccctt gtttcccatc   1440

aggaaatcca ccacaaagaa aaatgctatc agtgtaagga atgtgggaaa tccttcagtc   1500

agagtggcct tattcagcat cagagaattc acactgggga aaaaccctac aaatgtgacg   1560

tatgtgaaaa agcctttatt caaaggacaa gtcttacaga acatcagcga attcacactg   1620

gagaaagacc ctataaatgt gataagtgtg ggaaggcgtt tactcaaaga tcagtcctca   1680

cggaacatca gagaatccac actggagaga ggccctacaa gtgtgatgag tgtgggaatg   1740

ccttccgagg aatcaccagc ctcattcagc atcagagaat ccacactggg gagaagccct   1800

accaatgtga tgagtgtgga aaagccttca gacagaggaa gaagaccagc tacaaggaaa   1860

tacttctgaa aaatcactct gaaccccaag ctggagtgaa tcttctcctg agctctctca   1920

ttccagaatg gcaatcttgt ttcaggagag atctctaata gtgactgatg gtaaaggaag   1980

aaggctgtgc ctagaacaaa gaatcaggct ggcaaagaaa tcacaggtct ttcctcaaac   2040

tttaaattgc tactctctgg agatagctac ctggacttta cagagctgtc agaagacttg   2100

ggaaggtttg ccagcattgg aaaaagccac ttggacttca cagagctgtc agaagactta   2160

ggaagctttg ccagtagttc ctgagaccag aaatacatat tatgaagcag gtgctggaac   2220

aggccctggc ccctacttgt gaagctgcag atatagatgg tgttactgag aaggaaacta   2280

aggacttggc tccaaaacaa aacaaaacaa aatctggaga tgctgaattt tgttgggggg   2340

aatgtctgta gaactgcaac atcaatgcag taagtgtagt aaaagcttta gtttatggtg   2400

agtcattact cagcatcatg gagtccacga tgaagagaat ctcttttcaa tctgtgcaat   2460

caacaagttt ttgaaaggct tttgtttata gtggaaccct cttttccccc tagaagaacc   2520

accacaagga aaaatgctgt caccataagg aatgtgggaa agttttcagc cacatggcct   2580

tatttgactt caaagaatcc acatgagaga gagactgcat aaatgtaata actgaggagg   2640

cctttgttca gcaaagaaac cttatacaaa ctcgtataaa gaatgtagga agaccttcac   2700

ccagaagcca ggactgactg tgcaccagag aatctgcaca ataaacctga tgaatgtgga   2760

gatgcttgct tcagcattgg agaattcaca gtaaagggaa accctgccag tgtgatgagt   2820

acggaaaagt cttcagaggt tggaacttgg gaaaaatcag tgagtgaatt catattagag   2880

aggctcttat aaatgagagg attgtggaaa cttgtataga cagagatcag acctcaacaa   2940

gggagcctcc acagtattga aaagttaata taattaatgt aagtgggcaa gttgtatggg   3000

gaatgggtag tctaaattgc tcattttagc cagtaaaaac attaaattag tttcttagat   3060

caagaaaagg aaatgttaga agttattttt cccttccaga ggggtctata tgtgtaagca   3120

accaggactt ttgaaataag ttgcatctct ggatttgtga tctgtctcct ggatgattat   3180

ctctgttttg ggagacaggt attttttctt catgcctgct ctagtctcat ctcatatctt   3240

taattcattc agcaagtata cacaatagta ttatcgtcta ctgtttgttg taaatatata   3300

tatattattt tctttttggt ctgagtaggc ttgtattggt accctaggac ataaaaatca   3360

catatatcat gtttcagtaa atgcagtgaa aggaactata ttattaaatt gctgggaatt   3420

tctgtaaatt tgagactacc tttatattct ccaacacaag accgtgtagg tgtcccttca   3480

gagagtatat ttttctagct tggcttcttt attttcttta tttttttgag atggagtctt   3540

gctcctgtcg cccaggctgg agtgcaatgg cacgatctcg gctcactgca acctccgcct   3600

cccaggttca agtgattctc ctgtctcagt ctcccgagta gctgggatta caggcacttg   3660

ccaccattcc cagctaattt ttgtattttt agtagagacg gggtttcacc atgttggcca   3720

ggctggtctc gaactcctga ccttgtgatc tgcccacctt ggcctcccaa agttcaggga   3780

ttacaggcat gagccaccat gcccggctgt tttttttaag atagaaaaat atacttcatg   3840

tatagcctat tgacagataa tgactgatat tttttcttat agataacaca taataaacat   3900

tgtgaagact aaaaaaaaaa aaaaaaaaaa a                                  3931


<210>  1296
<211>  604
<212>  PRT
<213>  Homosapiens

<400>  1296

Met Ala Ser Thr Trp Ala Ile Gln Ala His Met Asp Gln Asp Glu Pro 
1               5                   10                  15      


Leu Glu Val Lys Ile Glu Glu Glu Lys Tyr Thr Thr Arg Gln Asp Trp 
            20                  25                  30          


Asp Leu Arg Lys Asn Asn Thr His Ser Arg Glu Val Phe Arg Gln Tyr 
        35                  40                  45              


Phe Arg Gln Phe Cys Tyr Gln Glu Thr Ser Gly Pro Arg Glu Ala Leu 
    50                  55                  60                  


Ser Arg Leu Arg Glu Leu Cys His Gln Trp Leu Arg Pro Glu Thr His 
65                  70                  75                  80  


Thr Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu Gln Phe Leu Thr 
                85                  90                  95      


Ile Leu Pro Glu Glu Leu Gln Ala Trp Val Gln Glu Gln His Pro Glu 
            100                 105                 110         


Ser Gly Glu Glu Val Val Thr Val Leu Glu Asp Leu Glu Arg Glu Leu 
        115                 120                 125             


Asp Glu Pro Gly Glu Gln Val Ser Val His Thr Gly Glu Gln Glu Met 
    130                 135                 140                 


Phe Leu Gln Glu Thr Val Arg Leu Arg Lys Glu Gly Glu Pro Ser Met 
145                 150                 155                 160 


Ser Leu Gln Ser Met Lys Ala Gln Pro Lys Tyr Glu Ser Pro Glu Leu 
                165                 170                 175     


Glu Ser Gln Gln Glu Gln Val Leu Asp Val Glu Thr Gly Asn Glu Tyr 
            180                 185                 190         


Gly Asn Leu Lys Gln Glu Val Ser Glu Glu Met Glu Pro His Gly Lys 
        195                 200                 205             


Thr Ser Ser Lys Phe Glu Asn Asp Met Ser Lys Ser Ala Arg Cys Gly 
    210                 215                 220                 


Glu Thr Arg Glu Pro Glu Glu Ile Thr Glu Glu Pro Ser Ala Cys Ser 
225                 230                 235                 240 


Arg Glu Asp Lys Gln Pro Thr Cys Asp Glu Asn Gly Val Ser Leu Thr 
                245                 250                 255     


Glu Asn Ser Asp His Thr Glu His Gln Arg Ile Cys Pro Gly Glu Glu 
            260                 265                 270         


Ser Tyr Gly Cys Asp Asp Cys Gly Lys Ala Phe Ser Gln His Ser His 
        275                 280                 285             


Leu Ile Glu His Gln Arg Ile His Thr Gly Asp Arg Pro Tyr Lys Cys 
    290                 295                 300                 


Glu Glu Cys Gly Lys Ala Phe Arg Gly Arg Thr Val Leu Ile Arg His 
305                 310                 315                 320 


Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly 
                325                 330                 335     


Lys Ala Phe Gly Arg Trp Ser Ala Leu Asn Gln His Gln Arg Leu His 
            340                 345                 350         


Thr Gly Glu Lys His Tyr His Cys Asn Asp Cys Gly Lys Ala Phe Ser 
        355                 360                 365             


Gln Lys Ala Gly Leu Phe His His Ile Lys Ile His Thr Arg Asp Lys 
    370                 375                 380                 


Pro Tyr Gln Cys Thr Gln Cys Asn Lys Ser Phe Ser Arg Arg Ser Ile 
385                 390                 395                 400 


Leu Thr Gln His Gln Gly Val His Thr Gly Ala Lys Pro Tyr Glu Cys 
                405                 410                 415     


Asn Glu Cys Gly Lys Ala Phe Val Tyr Asn Ser Ser Leu Val Ser His 
            420                 425                 430         


Gln Glu Ile His His Lys Glu Lys Cys Tyr Gln Cys Lys Glu Cys Gly 
        435                 440                 445             


Lys Ser Phe Ser Gln Ser Gly Leu Ile Gln His Gln Arg Ile His Thr 
    450                 455                 460                 


Gly Glu Lys Pro Tyr Lys Cys Asp Val Cys Glu Lys Ala Phe Ile Gln 
465                 470                 475                 480 


Arg Thr Ser Leu Thr Glu His Gln Arg Ile His Thr Gly Glu Arg Pro 
                485                 490                 495     


Tyr Lys Cys Asp Lys Cys Gly Lys Ala Phe Thr Gln Arg Ser Val Leu 
            500                 505                 510         


Thr Glu His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Asp 
        515                 520                 525             


Glu Cys Gly Asn Ala Phe Arg Gly Ile Thr Ser Leu Ile Gln His Gln 
    530                 535                 540                 


Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Asp Glu Cys Gly Lys 
545                 550                 555                 560 


Ala Phe Arg Gln Arg Lys Lys Thr Ser Tyr Lys Glu Ile Leu Leu Lys 
                565                 570                 575     


Asn His Ser Glu Pro Gln Ala Gly Val Asn Leu Leu Leu Ser Ser Leu 
            580                 585                 590         


Ile Pro Glu Trp Gln Ser Cys Phe Arg Arg Asp Leu 
        595                 600                 


<210>  1297
<211>  835
<212>  DNA
<213>  Homosapiens

<400>  1297
atgggagggc tctggcatcc gggatggagg cgcgtcgctt tctgtggctg gcgctggatc     60

caccctgggt ctccagccac ggctgcagag agggtagcgc ggtttcttag gccagagtgg    120

agtgggacag gaggtgccca gagacgactg tggtggcttg agacatggaa gcgctgcagc    180

ctttgagccc agtatccagc attgcagccg ccgcggcggt ctaagagctc aaaccctttc    240

aggcgcgcgc aggaggagga gcggcggggg cggcggaaca agacgaccct cacttaacgt    300

ggccgctgtc gccgtgggca tgctgggggc gtcctacgct gccgttcccc tttatcggct    360

ctattgccag actactggac ttggaggatc agcagtttca ggtcatgcct cagaccagat    420

tgaaaacatg gtgcctgtta aggatcgaat cattaaaatt aactttgatg cagatgtgca    480

tgcaagtctt cagtggaact ttagacttca gcaaacagaa atatatgtgg tgccaggaga    540

cactgcactg gggttttaca gagctaagaa tcctgctgac aaaccactaa ttggaatttc    600

tacatacaat gttgttccat ttgaagctgg acagtatttc aataaaatac agtgcttctg    660

ttttgaagaa caaaggctta atccccaaga ggaagtagat atgccagtgt ttttctacat    720

tgatcctgaa tttgctaaag acccaagaat gattaatgtt gatcttatca ctctttctta    780

cacttttttt gaagcaaagg aagggcacaa tttgccagtt ccaggatata actga         835


<210>  1298
<211>  1712
<212>  DNA
<213>  Homosapiens

<400>  1298
aaaaggggct gaaatcctgg ggacctcaga gtcgtctaaa actcctagcc atgttccagc     60

agttccaggc ctcctgtctt gtcctgtttt tcctggttgg ctttgctcag cagaccctaa    120

agcctcaaaa taggaaggtg gattgcaaca aaggggtaac aggcaccatc tatgagtatg    180

gagccctcac cctcaacggc gaggagtaca tccaattcaa gcagtttgca ggcaagcacg    240

tcctgtttgt caatgtggcc gcctattgag gcttggcagc tcagtatcct gaactgaatg    300

cactacagga ggagctgaag aattttggtg tcattgtgtt ggcctttccc tgcaaccagt    360

ttggaaaaca agaaccagga acaaactcag aaatacttct tggtctcaag tatgtgtgtc    420

caggtagtgg ctttgtcccc agtttccagc tctttgagaa aggggatgtg aatggagaaa    480

aagaacagaa ggtctttact ttcctgaaga actcctgccc tccgacctct gatcttttgg    540

gctcatcaag ccaactcttc tgggagccca tgaaggtcca tgatatccgc tggaactttg    600

agaaatttct ggtggggccc gatggagtcc ctgtcatgca ttggttccac caggctccag    660

tcagcacagt caagtcagac atcctggagt acctaaagca gttcaatacc cactaggaag    720

ggctagcgac tgacagaaat aactaccctg tctcccacct gcaggaatgt ctaacaaagc    780

atccatcttc ctccttcttt gctccacact cgtgcctacc cagcctcctg atgaccaaac    840

catcctgtac tacccaagca cctgcttagc atgtgtgtgt agctgtgtgt gtgtgtgtgt    900

gtgtgtgtat ggatatgtag aattgtattt gttggtatat gcataggtgt atgtatggtg    960

tgtgtgtgtg tgtgtgtgtg tgtgtttgaa gattaaggaa aagaacacct atctctccaa   1020

ctctctgatc ctgaaatatc tattccaaag gaaaatcata ttttagggta gatgaatcag   1080

actatcctgt gtccctaaaa aagcaatccc gagaagttgt gacatctatc ccttcccctt   1140

cctgaaagtt ttaaagaaag caggagctgg ccgcaagact ctaggcctcc ttcatagcct   1200

ctctcctcta agataggcat gcattgttaa actcttttct ccttaattct cctttattcc   1260

cctgccaccc agtagttctc atgtaggacc tctgaaggca gagtgagagc agaaacccca   1320

cctcacatga agggaagggc atctccatga tggtggatcc caaaacccct ctgggtcgca   1380

ccctgccaga gccttccttg gtgcctgtcc cttagtgcat tcaggtcatg gcacctgggc   1440

aggggtgtcc ctgtattctg aatgatgggc tttctcctca ccctgagcct cctcaacttt   1500

aagcttattt tgatcactgt ctcaaattta aaaattctgc agcaacctgg ctctgtgtgg   1560

tgttttccca gtcccatatt atgtccagtc atacttcttc tttctctgtc actttgtccc   1620

tgctttcttg attcccttgt cttgttcttc agtattttgt ttttctcaaa aatgctctag   1680

aactttcctt ggcacatata aaagcacggc tg                                 1712


<210>  1299
<211>  220
<212>  PRT
<213>  Homosapiens

<400>  1299

Met Phe Gln Gln Phe Gln Ala Ser Cys Leu Val Leu Phe Phe Leu Val 
1               5                   10                  15      


Gly Phe Ala Gln Gln Thr Leu Lys Pro Gln Asn Arg Lys Val Asp Cys 
            20                  25                  30          


Asn Lys Gly Val Thr Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Leu 
        35                  40                  45              


Asn Gly Glu Glu Tyr Ile Gln Phe Lys Gln Phe Ala Gly Lys His Val 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Ala Tyr Gly Leu Ala Ala Gln Tyr Pro Glu 
65                  70                  75                  80  


Leu Asn Ala Leu Gln Glu Glu Leu Lys Asn Phe Gly Val Ile Val Leu 
                85                  90                  95      


Ala Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Thr Asn Ser 
            100                 105                 110         


Glu Ile Leu Leu Gly Leu Lys Tyr Val Cys Pro Gly Ser Gly Phe Val 
        115                 120                 125             


Pro Ser Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys Glu 
    130                 135                 140                 


Gln Lys Val Phe Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ser Asp 
145                 150                 155                 160 


Leu Leu Gly Ser Ser Ser Gln Leu Phe Trp Glu Pro Met Lys Val His 
                165                 170                 175     


Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly Val 
            180                 185                 190         


Pro Val Met His Trp Phe His Gln Ala Pro Val Ser Thr Val Lys Ser 
        195                 200                 205             


Asp Ile Leu Glu Tyr Leu Lys Gln Phe Asn Thr His 
    210                 215                 220 


<210>  1300
<211>  668
<212>  DNA
<213>  Homosapiens

<400>  1300
tcatgactac acagttaagg gtcgtccatc tgcttcccct tctcctagcc tgctttgtgc     60

aaacaagtcc caagcaggag aagatgaaga tggattgcca caaagacgag aaaggcacca    120

tctatgacta tgaggccatc gcacttaata agaatgaata tgtttccttc aagcagtatg    180

tgggcaagca catcctcttc gtcaacgtgg ccacctactg tggtctgaca gcgcaatatc    240

ctgaactaaa tgcactccag gaggagctga agccctatgg tctagttgtg ttgggctttc    300

cctgcaacca atttggaaag caagaaccag gagataacaa agagattctt cctgggctca    360

agtatgtccg tccaggggga ggatttgtac ctagtttcca gctttttgag aaaggggatg    420

tgaatggtga aaaagaacag aaagtcttca gtttcttgaa gcactcctgt cctcatccct    480

ctgagatttt gggcacattc aaatctatat cctgggaccc tgtaaaggtc catgacatcc    540

gttggaactt tgaaaagttc ctggtggggc ctgatggaat ccctgtcatg cgctggtccc    600

accgggctac ggtcagctca gtcaagacag acatcctggc gtacttgaag caattcaaaa    660

ccaaatag                                                             668


<210>  1301
<211>  221
<212>  PRT
<213>  Homosapiens

<400>  1301

Met Thr Thr Gln Leu Arg Val Val His Leu Leu Pro Leu Leu Leu Ala 
1               5                   10                  15      


Cys Phe Val Gln Thr Ser Pro Lys Gln Glu Lys Met Lys Met Asp Cys 
            20                  25                  30          


His Lys Asp Glu Lys Gly Thr Ile Tyr Asp Tyr Glu Ala Ile Ala Leu 
        35                  40                  45              


Asn Lys Asn Glu Tyr Val Ser Phe Lys Gln Tyr Val Gly Lys His Ile 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Thr Tyr Cys Gly Leu Thr Ala Gln Tyr Pro 
65                  70                  75                  80  


Glu Leu Asn Ala Leu Gln Glu Glu Leu Lys Pro Tyr Gly Leu Val Val 
                85                  90                  95      


Leu Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Asp Asn 
            100                 105                 110         


Lys Glu Ile Leu Pro Gly Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe 
        115                 120                 125             


Val Pro Ser Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys 
    130                 135                 140                 


Glu Gln Lys Val Phe Ser Phe Leu Lys His Ser Cys Pro His Pro Ser 
145                 150                 155                 160 


Glu Ile Leu Gly Thr Phe Lys Ser Ile Ser Trp Asp Pro Val Lys Val 
                165                 170                 175     


His Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly 
            180                 185                 190         


Ile Pro Val Met Arg Trp Ser His Arg Ala Thr Val Ser Ser Val Lys 
        195                 200                 205             


Thr Asp Ile Leu Ala Tyr Leu Lys Gln Phe Lys Thr Lys 
    210                 215                 220     


<210>  1302
<211>  550
<212>  DNA
<213>  Homosapiens

<400>  1302
tcatgactac acagttaagg gtcgtccatc tgcttcccct tctcctagcc tgctttgtgc     60

aaacaagtcc caagcaggag aagatgaaga tggattgcca caaagacgag aaaggcacca    120

tctatgacta tgaggccatc gcacttaata agaatgaata tgtttccttc aagcagtatg    180

tgggcaagca catcctcttc gtcaacgtgg ccacctactg tggtctgaca gcgcaatatc    240

ctggtatgtc cgtccagggg gaggatttgt acctagtttc cagctttttg agaaagggga    300

tgtgaatggt gaaaaagaac agaaagtctt cagtttcttg aagcactcct gtcctcatcc    360

ctctgagatt ttgggcacat tcaaatctat atcctgggac cctgtaaagg tccatgacat    420

ccgttggaac tttgaaaagt tcctggtggg gcctgatgga atccctgtca tgcgctggtc    480

ccaccgggct acggtcagct cagtcaagac agacatcctg gcgtacttga agcaattcaa    540

aaccaaatag                                                           550


<210>  1303
<211>  100
<212>  PRT
<213>  Homosapiens

<400>  1303

Met Thr Thr Gln Leu Arg Val Val His Leu Leu Pro Leu Leu Leu Ala 
1               5                   10                  15      


Cys Phe Val Gln Thr Ser Pro Lys Gln Glu Lys Met Lys Met Asp Cys 
            20                  25                  30          


His Lys Asp Glu Lys Gly Thr Ile Tyr Asp Tyr Glu Ala Ile Ala Leu 
        35                  40                  45              


Asn Lys Asn Glu Tyr Val Ser Phe Lys Gln Tyr Val Gly Lys His Ile 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Thr Tyr Cys Gly Leu Thr Ala Gln Tyr Pro 
65                  70                  75                  80  


Gly Met Ser Val Gln Gly Glu Asp Leu Tyr Leu Val Ser Ser Phe Leu 
                85                  90                  95      


Arg Lys Gly Met 
            100 


<210>  1304
<211>  4895
<212>  DNA
<213>  Homosapiens

<400>  1304
gagcgtggct caccgggccc ggccggaacc tacgggcaca gctgcgggtg tgtctgcgga     60

acctccacct gagctgtaga gtgtttccct cgacccacta gtctgggttc cacagggtct    120

gagctcctca gaggtgggag ctgcggccga gggaagggtg catgtgcgcg gcgacaatcg    180

ggcctcttcc ccaggcagct tgtgagcccc tctccctctc cgccctcgcc caggctgctc    240

cgatcttcgt ttccttgcct aggctcatac acccaggctt tatttagggc caaagtatcc    300

gtcataacct cggttttctg tctcgcaagt atcttgccgc tcaatttgtg accctgaagc    360

tttagtgagt cgctctgtgc tcactatttc tggtcttttc agaggatggc ttcactttca    420

atggaattgc ccgagtaact gccctgtgtt gtcacgtaaa caagtccttt taaactgagt    480

ctgtagttgt cctgtgttga gtgttttctt atatcaaaaa ctttcctgac caagaacaaa    540

aaaggagctc aagtaaaatc acccatttgc ctagacccca actggagaga acctttgcct    600

gagctgtcta agctcgggat ggaagcagtc tctagggtct tcccagcctt ggctggccag    660

gctccagaag aacaagggga gattatcaaa gtaaaggtta aagaagaaga ccacacttgg    720

gatcaggaat cagccctacg taggaatttg tcttatacca gggaactctc tcgtcagcgc    780

ttcaggcagt tctgctatca ggagacacct gggcccaggg aggctctgag tcaactgcgg    840

gaactttgcc gtcagtggct gaacccagag atacatacca aggagcagat cctggaattg    900

ttggtgctgg agcagttcct gaccatcctg cctgaggagc tccagtcttg ggtgcgggag    960

cataatcctg agagtggaga agaggtggtg actttgctgg aagatttgga gagggagctt   1020

gatgaaccta gacagcaggt ctcacagggc acatatgggc aggaagtttc tatggaagaa   1080

atgatccctc tggattctgc aaaggagtct ttaggcaccc agcttcagtc tatggaagat   1140

agaatggaat gtgaatctcc agagccacac ccacttcaag ataatgggtc atttttgtgg   1200

ttttccatga tgtctcaaag catgggtggt gataacctca gtagcttaga tactaatgaa   1260

gcagaaattg aaccagaaaa catgagagaa aagttcttca gaagcttagc aaggttactg   1320

gaaaacaaaa gtaataatac taagatattt tctaaagcaa agtactgtca gttgataaag   1380

gaagtgaaag aagctaaagc taaggcgaaa aaggaatcag ttgactaccg tcgcttggct   1440

agatttgatg ttatccttgt acaaggaaat gagaagctaa ttgaggctgt aaatggggaa   1500

acagataaaa tacggtatta cttacacagt gaggacttat ttgacattct gcataataca   1560

catctcagca ttggacatgg tggacgtact cgcatggaga aagagttaca agcgaaatac   1620

aagaacatca caaaagaagt tataatgctg tatctgaccc tctgtaaacc atgccaacag   1680

aaaaattcaa aactcaagaa ggttctaaca tcaaaatcaa ttaaggaagt tagttcaaga   1740

tgccaagtag atcttataga catgcagttg aatcctgatg gggagtacag atttattttg   1800

cattatcaag atctctgtac aaagttaact tttttgcggt cattaaagtc taaaaggcct   1860

acggaagttg cacatgctct tttagatata tttacaatta ttggagcacc cagtgtccta   1920

caatctgaca atgggaggga attttcaagc caggttgtca gtgaactcag taatatttgg   1980

ccagaattga aaattgtcca tgggaagtct cagacctgcc aaagccagag ttctgcagaa   2040

caaactgagg atatccgaaa gaggattttc tcctggatgc aaactaacaa ctcatcacac   2100

tggactgaat ttttgtggtt cattcagatg tcccaaaatc agccctatca cagaagcatg   2160

caacagactc catgtgaaag tgcatttagc tctgaagcta aactgggctt gtcccattct   2220

cagctaactg aagaacttgt tgccagcttg catacagaaa atgaattaga tcaggctgac   2280

aaagagttag aaaatacttt aagagcccag tatgaagaaa acattgagac tggaacagac   2340

agtagtgata ttgaagagaa tctttctgtc actcctaagg tggctgaaaa aagccctcct   2400

gagagcagac taagattttt atcctgtgta gtttgtgaaa aagaatgcac aggtgttaat   2460

agttgtatat catgtgatgg aaatatccat gcaatttgtg gagtgccctc tcaacatggg   2520

actgagggct gtggtcggca aataacttgt agcctttgct atgaaaccag cacaatgaag   2580

aggaaacatg atgagattca aagaagtttg cctgttaaac cttccaaaat gctaaagcca   2640

tcagggacac cattttcacc agacaaagta ggagactgga tggcgaaaca agcttcactg   2700

gacttttttg tcaagaaaag acatgccttt tctgaacaca gtagtagtaa taaaagaaat   2760

gttaacaata gaagttatcc tgaagaaggg aaaaccaaaa gagttcatgc tagtttcact   2820

cggaaatatg atccttcata tattgagttt ggttttgtag ctgtaattga tggtgaagta   2880

ctaaaaccac agtgtattat ttgtggagat gtactggcta atgaagcaat gaaaccatca   2940

aaacttaagc gacatttata ttcaaaacat aaagaaataa gttcacaacc aaaagaattc   3000

tttgaaagaa agagtagtga attgaaaagc caaccaaagc aggtgttcaa cgtttctcat   3060

ataaacatta gtgctttgcg ggcttcatat aaagtagcac ttccggttgc caagtctaaa   3120

acaccataca caattgctga gacactagtg aaagactgca tcaaagaagt ttgcttggaa   3180

atgttgggtg aatctgcagc aaagaaggta gctcaggtac cactttccaa tgacaccata   3240

gctcgacgta ttcaggaact ggctaatgat atggaagatc aactcataga acaaataaaa   3300

ctagcaaagt atttttcatt gcaacttgat gaatgcagag atattgctaa catgataatt   3360

cttttagtct atgtgaggtt tgaacatgat gatgatataa aggaagagtt ctttttttca   3420

gcctctttgc ctacaaacac aactagctca gaactgtatg aagctgtaaa gaattatatt   3480

gttaacaaat gtggtttgga atttaaattt tgtgtaggag tatgttctga tggtgcagct   3540

tcaatgacag gaaaacattc tgaagtggta acccagatta aggaacttgc gccagaatgt   3600

aaaacaacac attgcttcat tcatcgagaa agtcttgcca tgaaaaaaat atcagctgaa   3660

ctaaatagtg tacttaatga tatagtaaaa attgtgaatt atataaaatc taattcattg   3720

aattcaagat tattctcttt attatgtgat aatatggaag ctgatcataa gcaactgtta   3780

ctgcatgctg agatacggtg gttatcacgg ggaaaagttc tgtcaagaat gtttgaaata   3840

cgaaatgaac tcttagtgtt tctgcaaggc aagaaaccca tgtggtccca actttttaaa   3900

gatgtgaatt ggacagccag acttgcttat ttgtctgata tcttcagtat ttttaatgat   3960

cttaatgctt ctatgcaagg gaagaatgca acttattttt caatggcaga taaagttgaa   4020

ggacaaaaac agaagttaga agcttggaaa aacagaattt ctacagattg ttatgacatg   4080

tttcataatt taacaacaat tatcaatgaa gtaggtaatg atcttgatat tgcacatctg   4140

cgaaaagtta tcagtgaaca tcttacaaat ttgttagaat gttttgaatt ttattttcca   4200

tcaaaagaag atccacgcat aggaaatttg tggatccaaa atccatttct ttcatcaaaa   4260

gataacttaa atttaactgt aactctacag gataagttgt tgaagctggc taccgacgaa   4320

ggattgaaaa tcagttttga aaatacagca tcacttcctt cattttggat aaaagctaaa   4380

aatgactatc ctgagcttgc tgagattgct ttaaaattgc tgcttctttt cccctcaaca   4440

tacctctgtg agaccggatt ctctacttta agtgttatta aaacaaaaca tagaaacagt   4500

ttaaatatac attatcccct gagggtagca ttgtcatcaa tccaacctag attagacaaa   4560

ttaacaagca agaagcaagc tcacttatca cattaaaagc tttaaatatt gatatgtaag   4620

gtattggttc aaagtatgca tataagcatt gagtgtgagg aatttgctat ttcactttaa   4680

actttctgtc tagttacagt tatggaagta tgagaagtta tgagtgaaac agcaattttc   4740

tatataaatt gcctatatgt atattttcaa ttaagaatgt gtacagtttt tataattcta   4800

tttttcctca tatttgtcgt atttattaaa atataatttt aaatctgttg attctaatat   4860

taaaacattt gatcttaaaa aaaaaaaaaa aaaaa                              4895


<210>  1305
<211>  1325
<212>  PRT
<213>  Homosapiens

<400>  1305

Met Glu Ala Val Ser Arg Val Phe Pro Ala Leu Ala Gly Gln Ala Pro 
1               5                   10                  15      


Glu Glu Gln Gly Glu Ile Ile Lys Val Lys Val Lys Glu Glu Asp His 
            20                  25                  30          


Thr Trp Asp Gln Glu Ser Ala Leu Arg Arg Asn Leu Ser Tyr Thr Arg 
        35                  40                  45              


Glu Leu Ser Arg Gln Arg Phe Arg Gln Phe Cys Tyr Gln Glu Thr Pro 
    50                  55                  60                  


Gly Pro Arg Glu Ala Leu Ser Gln Leu Arg Glu Leu Cys Arg Gln Trp 
65                  70                  75                  80  


Leu Asn Pro Glu Ile His Thr Lys Glu Gln Ile Leu Glu Leu Leu Val 
                85                  90                  95      


Leu Glu Gln Phe Leu Thr Ile Leu Pro Glu Glu Leu Gln Ser Trp Val 
            100                 105                 110         


Arg Glu His Asn Pro Glu Ser Gly Glu Glu Val Val Thr Leu Leu Glu 
        115                 120                 125             


Asp Leu Glu Arg Glu Leu Asp Glu Pro Arg Gln Gln Val Ser Gln Gly 
    130                 135                 140                 


Thr Tyr Gly Gln Glu Val Ser Met Glu Glu Met Ile Pro Leu Asp Ser 
145                 150                 155                 160 


Ala Lys Glu Ser Leu Gly Thr Gln Leu Gln Ser Met Glu Asp Arg Met 
                165                 170                 175     


Glu Cys Glu Ser Pro Glu Pro His Pro Leu Gln Asp Asn Gly Ser Phe 
            180                 185                 190         


Leu Trp Phe Ser Met Met Ser Gln Ser Met Gly Gly Asp Asn Leu Ser 
        195                 200                 205             


Ser Leu Asp Thr Asn Glu Ala Glu Ile Glu Pro Glu Asn Met Arg Glu 
    210                 215                 220                 


Lys Phe Phe Arg Ser Leu Ala Arg Leu Leu Glu Asn Lys Ser Asn Asn 
225                 230                 235                 240 


Thr Lys Ile Phe Ser Lys Ala Lys Tyr Cys Gln Leu Ile Lys Glu Val 
                245                 250                 255     


Lys Glu Ala Lys Ala Lys Ala Lys Lys Glu Ser Val Asp Tyr Arg Arg 
            260                 265                 270         


Leu Ala Arg Phe Asp Val Ile Leu Val Gln Gly Asn Glu Lys Leu Ile 
        275                 280                 285             


Glu Ala Val Asn Gly Glu Thr Asp Lys Ile Arg Tyr Tyr Leu His Ser 
    290                 295                 300                 


Glu Asp Leu Phe Asp Ile Leu His Asn Thr His Leu Ser Ile Gly His 
305                 310                 315                 320 


Gly Gly Arg Thr Arg Met Glu Lys Glu Leu Gln Ala Lys Tyr Lys Asn 
                325                 330                 335     


Ile Thr Lys Glu Val Ile Met Leu Tyr Leu Thr Leu Cys Lys Pro Cys 
            340                 345                 350         


Gln Gln Lys Asn Ser Lys Leu Lys Lys Val Leu Thr Ser Lys Ser Ile 
        355                 360                 365             


Lys Glu Val Ser Ser Arg Cys Gln Val Asp Leu Ile Asp Met Gln Leu 
    370                 375                 380                 


Asn Pro Asp Gly Glu Tyr Arg Phe Ile Leu His Tyr Gln Asp Leu Cys 
385                 390                 395                 400 


Thr Lys Leu Thr Phe Leu Arg Ser Leu Lys Ser Lys Arg Pro Thr Glu 
                405                 410                 415     


Val Ala His Ala Leu Leu Asp Ile Phe Thr Ile Ile Gly Ala Pro Ser 
            420                 425                 430         


Val Leu Gln Ser Asp Asn Gly Arg Glu Phe Ser Ser Gln Val Val Ser 
        435                 440                 445             


Glu Leu Ser Asn Ile Trp Pro Glu Leu Lys Ile Val His Gly Lys Ser 
    450                 455                 460                 


Gln Thr Cys Gln Ser Gln Ser Ser Ala Glu Gln Thr Glu Asp Ile Arg 
465                 470                 475                 480 


Lys Arg Ile Phe Ser Trp Met Gln Thr Asn Asn Ser Ser His Trp Thr 
                485                 490                 495     


Glu Phe Leu Trp Phe Ile Gln Met Ser Gln Asn Gln Pro Tyr His Arg 
            500                 505                 510         


Ser Met Gln Gln Thr Pro Cys Glu Ser Ala Phe Ser Ser Glu Ala Lys 
        515                 520                 525             


Leu Gly Leu Ser His Ser Gln Leu Thr Glu Glu Leu Val Ala Ser Leu 
    530                 535                 540                 


His Thr Glu Asn Glu Leu Asp Gln Ala Asp Lys Glu Leu Glu Asn Thr 
545                 550                 555                 560 


Leu Arg Ala Gln Tyr Glu Glu Asn Ile Glu Thr Gly Thr Asp Ser Ser 
                565                 570                 575     


Asp Ile Glu Glu Asn Leu Ser Val Thr Pro Lys Val Ala Glu Lys Ser 
            580                 585                 590         


Pro Pro Glu Ser Arg Leu Arg Phe Leu Ser Cys Val Val Cys Glu Lys 
        595                 600                 605             


Glu Cys Thr Gly Val Asn Ser Cys Ile Ser Cys Asp Gly Asn Ile His 
    610                 615                 620                 


Ala Ile Cys Gly Val Pro Ser Gln His Gly Thr Glu Gly Cys Gly Arg 
625                 630                 635                 640 


Gln Ile Thr Cys Ser Leu Cys Tyr Glu Thr Ser Thr Met Lys Arg Lys 
                645                 650                 655     


His Asp Glu Ile Gln Arg Ser Leu Pro Val Lys Pro Ser Lys Met Leu 
            660                 665                 670         


Lys Pro Ser Gly Thr Pro Phe Ser Pro Asp Lys Val Gly Asp Trp Met 
        675                 680                 685             


Ala Lys Gln Ala Ser Leu Asp Phe Phe Val Lys Lys Arg His Ala Phe 
    690                 695                 700                 


Ser Glu His Ser Ser Ser Asn Lys Arg Asn Val Asn Asn Arg Ser Tyr 
705                 710                 715                 720 


Pro Glu Glu Gly Lys Thr Lys Arg Val His Ala Ser Phe Thr Arg Lys 
                725                 730                 735     


Tyr Asp Pro Ser Tyr Ile Glu Phe Gly Phe Val Ala Val Ile Asp Gly 
            740                 745                 750         


Glu Val Leu Lys Pro Gln Cys Ile Ile Cys Gly Asp Val Leu Ala Asn 
        755                 760                 765             


Glu Ala Met Lys Pro Ser Lys Leu Lys Arg His Leu Tyr Ser Lys His 
    770                 775                 780                 


Lys Glu Ile Ser Ser Gln Pro Lys Glu Phe Phe Glu Arg Lys Ser Ser 
785                 790                 795                 800 


Glu Leu Lys Ser Gln Pro Lys Gln Val Phe Asn Val Ser His Ile Asn 
                805                 810                 815     


Ile Ser Ala Leu Arg Ala Ser Tyr Lys Val Ala Leu Pro Val Ala Lys 
            820                 825                 830         


Ser Lys Thr Pro Tyr Thr Ile Ala Glu Thr Leu Val Lys Asp Cys Ile 
        835                 840                 845             


Lys Glu Val Cys Leu Glu Met Leu Gly Glu Ser Ala Ala Lys Lys Val 
    850                 855                 860                 


Ala Gln Val Pro Leu Ser Asn Asp Thr Ile Ala Arg Arg Ile Gln Glu 
865                 870                 875                 880 


Leu Ala Asn Asp Met Glu Asp Gln Leu Ile Glu Gln Ile Lys Leu Ala 
                885                 890                 895     


Lys Tyr Phe Ser Leu Gln Leu Asp Glu Cys Arg Asp Ile Ala Asn Met 
            900                 905                 910         


Ile Ile Leu Leu Val Tyr Val Arg Phe Glu His Asp Asp Asp Ile Lys 
        915                 920                 925             


Glu Glu Phe Phe Phe Ser Ala Ser Leu Pro Thr Asn Thr Thr Ser Ser 
    930                 935                 940                 


Glu Leu Tyr Glu Ala Val Lys Asn Tyr Ile Val Asn Lys Cys Gly Leu 
945                 950                 955                 960 


Glu Phe Lys Phe Cys Val Gly Val Cys Ser Asp Gly Ala Ala Ser Met 
                965                 970                 975     


Thr Gly Lys His Ser Glu Val Val Thr Gln Ile Lys Glu Leu Ala Pro 
            980                 985                 990         


Glu Cys Lys Thr Thr His Cys Phe  Ile His Arg Glu Ser  Leu Ala Met 
        995                 1000                 1005             


Lys Lys  Ile Ser Ala Glu Leu  Asn Ser Val Leu Asn  Asp Ile Val 
    1010                 1015                 1020             


Lys Ile  Val Asn Tyr Ile Lys  Ser Asn Ser Leu Asn  Ser Arg Leu 
    1025                 1030                 1035             


Phe Ser  Leu Leu Cys Asp Asn  Met Glu Ala Asp His  Lys Gln Leu 
    1040                 1045                 1050             


Leu Leu  His Ala Glu Ile Arg  Trp Leu Ser Arg Gly  Lys Val Leu 
    1055                 1060                 1065             


Ser Arg  Met Phe Glu Ile Arg  Asn Glu Leu Leu Val  Phe Leu Gln 
    1070                 1075                 1080             


Gly Lys  Lys Pro Met Trp Ser  Gln Leu Phe Lys Asp  Val Asn Trp 
    1085                 1090                 1095             


Thr Ala  Arg Leu Ala Tyr Leu  Ser Asp Ile Phe Ser  Ile Phe Asn 
    1100                 1105                 1110             


Asp Leu  Asn Ala Ser Met Gln  Gly Lys Asn Ala Thr  Tyr Phe Ser 
    1115                 1120                 1125             


Met Ala  Asp Lys Val Glu Gly  Gln Lys Gln Lys Leu  Glu Ala Trp 
    1130                 1135                 1140             


Lys Asn  Arg Ile Ser Thr Asp  Cys Tyr Asp Met Phe  His Asn Leu 
    1145                 1150                 1155             


Thr Thr  Ile Ile Asn Glu Val  Gly Asn Asp Leu Asp  Ile Ala His 
    1160                 1165                 1170             


Leu Arg  Lys Val Ile Ser Glu  His Leu Thr Asn Leu  Leu Glu Cys 
    1175                 1180                 1185             


Phe Glu  Phe Tyr Phe Pro Ser  Lys Glu Asp Pro Arg  Ile Gly Asn 
    1190                 1195                 1200             


Leu Trp  Ile Gln Asn Pro Phe  Leu Ser Ser Lys Asp  Asn Leu Asn 
    1205                 1210                 1215             


Leu Thr  Val Thr Leu Gln Asp  Lys Leu Leu Lys Leu  Ala Thr Asp 
    1220                 1225                 1230             


Glu Gly  Leu Lys Ile Ser Phe  Glu Asn Thr Ala Ser  Leu Pro Ser 
    1235                 1240                 1245             


Phe Trp  Ile Lys Ala Lys Asn  Asp Tyr Pro Glu Leu  Ala Glu Ile 
    1250                 1255                 1260             


Ala Leu  Lys Leu Leu Leu Leu  Phe Pro Ser Thr Tyr  Leu Cys Glu 
    1265                 1270                 1275             


Thr Gly  Phe Ser Thr Leu Ser  Val Ile Lys Thr Lys  His Arg Asn 
    1280                 1285                 1290             


Ser Leu  Asn Ile His Tyr Pro  Leu Arg Val Ala Leu  Ser Ser Ile 
    1295                 1300                 1305             


Gln Pro  Arg Leu Asp Lys Leu  Thr Ser Lys Lys Gln  Ala His Leu 
    1310                 1315                 1320             


Ser His  
    1325 


<210>  1306
<211>  2446
<212>  DNA
<213>  Homosapiens

<400>  1306
cccagtatta tcgaagatca agcaagaaag aaaaagacag aaaacaaatg cgaaaccaca     60

gcttccttgg ctctttttgc ccatatgccg aagagccgag cattgccgcc aagcattggc    120

accggccatg cggagactag cgaaagcttt gcaattcctc tacttctcag tgatgactcg    180

ggctttctcc ttacattctt gatgggcatg accggtcctg tcagctgggt ggccaatttc    240

tgttcttcag cagaactgtc tcccttcttg ggggccgagg gctttctggg gaagaggatg    300

agtttggagc aatactcatt cagacgctgc acattggcct gcagggaatc ggtggacttg    360

ttctgcctcc tcggatccac agagatgcca gtggtccggg tcaccttctt gtgaatgccc    420

gccaccctga gctccaggct gaagcctctg ccggcgcgca ccttgatgtg ataacgcaca    480

gcagggcaca gcacaatggg ccagatgggt cccgactctc cgggcgcggg gcgatgcagc    540

gccctttggc ttgccgggcc ttgattctgc ggatcttctg gttgaaccac gtggccacac    600

gctgctgcca gtccttgtgg aagtggggct tcaacatcat gccattcctg ctgggcgcca    660

tggctgccta cggccctcct acgaaggaaa cactttatag atttctatag cagtgttaca    720

tagtaaggtt ttatggcgag ttttgtagca tggatcatac taccttagga ctgatggtaa    780

agttttagtc taaggaaagc tctgaaaatt tgaaaatgtg taaccaccca atgagttcag    840

cttgcccact gcctagacag aaccatttat caagacgggc atgcaaagcc ggctgtgtgg    900

gagacccgtt ttattattat tcaaatcagt ctccccaagt ggattgcagt ttttaaggat    960

aatttggtgg gtaggggacc agtgagttgg gaaagttgat tagtcgggtc ggagatgaaa   1020

tcagagggag tcgaagctgt cctcttgtgt tggcttaatt tctggatggg ggccacaaga   1080

ccagatgagc cagtttatcg ttatgggtgg tgctagctga tccatagagt acaggggctg   1140

caaaatatct caagaactga tcttcggttt tacaatagtg atgttatcct gaggagcaat   1200

tgggggaggt ttagaatctt gcagcctcca gctgcatgac tcctaaacca taatttataa   1260

tcttgtggct aatttgttag tcctgcgaaa gcagtctagt ccccaggcag gaagcgggtt   1320

tgttttggaa agggctgcta ttgtctttgt ttcaaagcta aactataaac taagttcctc   1380

ccaaagttag gtcagcctac gaccaggaat gaacaaggac agcttggagg ttagaagcaa   1440

gatggaattg gttaggttag atctctcact gtctcagttg taattttgcg atggtgtttt   1500

caaatgttga tttaaagaag accataaatt tgtgttgctt tctcagattt tgagaataag   1560

gacaaaaagt gtatgtttta atgggagaat cttaagaatt tcactactga agtggatttc   1620

tctgtccatt aacagtgcta aatgttttgt atttcccagt tggaaaaaca aaatctgcaa   1680

gctttgaatg atacttgtta ttaggttttg gtaacagctg ttgtactatt cccatttcaa   1740

tgctcaatag ccacacgtgg catgtcatac ctaccaggtg gacagcacag atatagaaca   1800

ttttcatcat tgtaaaaagc cctatttgac aacactaact taaagtatta atcttttaga   1860

agagaaagct tcagtccaac ccaaattaca caattttact tttgaaaata ttgttgaaac   1920

aacgttcaat tttttaaaat tttggaaaac tgaatgaaat ccatttgtaa atgcgcaaat   1980

ggtactggag gtggaaaact gaagccttgc tatagtttta gttttttgga gggttatgat   2040

caacacagag aagaaaagat tcatctaccc atagagcttc ttgagaaaaa ttttctaaca   2100

ataattttga aaatttgtag tgaatttgtt cttgccatta tttatgggtg ctttcatgtg   2160

cgaggcacat caaagttctg gggaatgact taggcacaac caaatggcta tcttgggaag   2220

accaaagtcc tttgctatat atgagagttt tgagatggcg actacctttc tgtatggtag   2280

attcttgttt ttgaatatgc cctctgggtt ttcaaaacaa attgttttta caatacctat   2340

agtagttatc tagggcatat tctttagctt caaaaattct atctttagaa tgggcttcaa   2400

tattcataac tgagttattt tcctctaata aatcattaac attttc                  2446


<210>  1307
<211>  2984
<212>  DNA
<213>  Homosapiens

<400>  1307
gttttacgct gccgccggca tccgctcgga cgcggccacg ttgtcttgcg cgctttgccc     60

gcctggccct gggactctga ccctcggcta ccctttcctg ccccactagc gtggccgcga    120

gcctcggtga gccggccgta ttcccgctct cgcttagggg gcacaggcgc aggcatcggc    180

ccggccactc caagccttcg gtgcgcgggc gcgtctggga tacgggcccg ggaggcgccg    240

ccctccgtcc gcccggtgcc tctcaggaac agcgaaccgg agagagcgcc ggagagttgg    300

gctcagtgcg gagctcggcg ccggggccca tgcccgtgcg cccccgcagg ccggcgccat    360

ggcctccggg agtgtggccg agtgcctgca gcaggagacc acctgccccg tgtgcctgca    420

gtacttcgca gagcccatga tgctcgactg cggccataac atctgttgcg cgtgcctcgc    480

ccgctgctgg ggcacggcag agactaacgt gtcgtgcccg cagtgccggg agaccttccc    540

gcagaggcac atgcggccca accggcacct ggccaacgtg acccaactgg taaagcagct    600

gcgcaccgag cggccgtcgg ggcccggcgg cgagatgggc gtgtgcgaga agcaccgcga    660

gcccctgaag ctgtactgcg aggaggacca gatgcccatc tgcgtggtgt gcgaccgctc    720

ccgcgagcac cgcggccaca gcgtgctgcc gctcgaggag gcggtggagg gcttcaagga    780

gcaaatccag aaccagctcg accatttaaa aagagtgaaa gatttaaaga agagacgtcg    840

ggcccagggg gaacaggcac gagctgaact cttgagccta acccagatgg agagggagaa    900

gattgtttgg gagtttgagc agctgtatca ctccttaaag gagcatgagt atcgcctcct    960

ggcccgcctt gaggagctag acttggccat ctacaatagc atcaatggtg ccatcaccca   1020

gttctcttgc aacatctccc acctcagcag cctgatcgct cagctagaag agaagcagca   1080

gcagcccacc agggagctcc tgcaggacat tggggacaca ttgagcaggg ctgaaagaat   1140

caggattcct gaaccttgga tcacacctcc agatttgcaa gagaaaatcc acatttttgc   1200

ccaaaaatgt ctattcttga cggagagtct aaagcagttc acagaaaaaa tgcagtcaga   1260

tatggagaaa atccaagaat taagagaggc tcagttatac tcagtggacg tgactctgga   1320

cccagacacg gcctacccca gcctgatcct ctctgataat ctgcggcaag tgcggtacag   1380

ttacctccaa caggacctgc ctgacaaccc cgagaggttc aatctgtttc cctgtgtctt   1440

gggctctcca tgcttcatcg ccgggagaca ttattgggag gtagaggtgg gagataaagc   1500

caagtggacc ataggtgtct gtgaagactc agtgtgcaga aaaggtggag taacctcagc   1560

cccccagaat ggattctggg cagtgtcttt gtggtatggg aaagaatatt gggctcttac   1620

ctccccaatg actgccctac ccctgcggac cccgctccag cgggtgggga ttttcttgga   1680

ctatgatgct ggtgaggtct ccttctacaa cgtgacagag aggtgtcaca ccttcacttt   1740

ctctcatgct accttttgtg ggcctgtccg gccctacttc agtctgagtt actcgggagg   1800

gaaaagtgca gctcctctga tcatctgccc catgagtggg atagatgggt tttctggcca   1860

tgttgggaat catggtcatt ccatggagac ctccccttga ggaggtgaat tcaggccaaa   1920

agggctgttg gctgtaatcc tacgccaggc acaaggcatc ttgttgcctt gccacgtcct   1980

gtcacagctg ggtatcctta ccatgttcca cgcccttgca gtgggagaca ggatgtccat   2040

gttctctacc atccttttcc ttcccatgca gattgtgaaa tgtaatgaga tgtatcaaga   2100

catcctagaa ataaaaacca gatgtccacc tccagtgttt catactttct ggttttacac   2160

atcgctggag ggataaagag tatggataat ctttggattt ggagagccgt tcaagatact   2220

tccagcttct tggctcagcc tggcttcctc tggttcagcc ccacataatg attatggcta   2280

tttgctgtca tttctgggct agggctcctt tctaacaacc tagactggaa taaggccctg   2340

tcagcatggc tccctttatc ccagttttcc gtctgggaac agtacctctg cccctgattc   2400

ccaatgtgcc atagttttat taactccatt aaagaagcct gtatgtgttt tggttagtta   2460

cagttatttt acaataatgg tgggtaatgg ccccacctct gttatgagat aatgttctaa   2520

tcaatgtctc tgcctttgta tcttttctga gggctttgtc tgttctcttc attctaatga   2580

aaggtgtatt ctagtgctgg gtgcatatca tccaggataa tattctgccc aactccatcc   2640

tctgttacta gatcccttac cagtcacatt tgtggactgg tggccagtcg tataccatcc   2700

ctggaaggat tctgggacaa tattccaggg attcattgac ttcttggctc cttttctcca   2760

tttcctttgg gggaaggggg aattgaccat gcttaagtgc atcctatcaa ggggcagctc   2820

cgtccccatg gccattggat catgagacac tcgaagtcag aaggctgggg cagatcactt   2880

caagcaagcc cccatgatgg ttctcagtcc tgcttctctg tgggtacgtg cccctctgtt   2940

taaaaataaa ctgaatatgg atgtttaaaa aaaaaaaaaa aaaa                    2984


<210>  1308
<211>  513
<212>  PRT
<213>  Homosapiens

<400>  1308

Met Ala Ser Gly Ser Val Ala Glu Cys Leu Gln Gln Glu Thr Thr Cys 
1               5                   10                  15      


Pro Val Cys Leu Gln Tyr Phe Ala Glu Pro Met Met Leu Asp Cys Gly 
            20                  25                  30          


His Asn Ile Cys Cys Ala Cys Leu Ala Arg Cys Trp Gly Thr Ala Glu 
        35                  40                  45              


Thr Asn Val Ser Cys Pro Gln Cys Arg Glu Thr Phe Pro Gln Arg His 
    50                  55                  60                  


Met Arg Pro Asn Arg His Leu Ala Asn Val Thr Gln Leu Val Lys Gln 
65                  70                  75                  80  


Leu Arg Thr Glu Arg Pro Ser Gly Pro Gly Gly Glu Met Gly Val Cys 
                85                  90                  95      


Glu Lys His Arg Glu Pro Leu Lys Leu Tyr Cys Glu Glu Asp Gln Met 
            100                 105                 110         


Pro Ile Cys Val Val Cys Asp Arg Ser Arg Glu His Arg Gly His Ser 
        115                 120                 125             


Val Leu Pro Leu Glu Glu Ala Val Glu Gly Phe Lys Glu Gln Ile Gln 
    130                 135                 140                 


Asn Gln Leu Asp His Leu Lys Arg Val Lys Asp Leu Lys Lys Arg Arg 
145                 150                 155                 160 


Arg Ala Gln Gly Glu Gln Ala Arg Ala Glu Leu Leu Ser Leu Thr Gln 
                165                 170                 175     


Met Glu Arg Glu Lys Ile Val Trp Glu Phe Glu Gln Leu Tyr His Ser 
            180                 185                 190         


Leu Lys Glu His Glu Tyr Arg Leu Leu Ala Arg Leu Glu Glu Leu Asp 
        195                 200                 205             


Leu Ala Ile Tyr Asn Ser Ile Asn Gly Ala Ile Thr Gln Phe Ser Cys 
    210                 215                 220                 


Asn Ile Ser His Leu Ser Ser Leu Ile Ala Gln Leu Glu Glu Lys Gln 
225                 230                 235                 240 


Gln Gln Pro Thr Arg Glu Leu Leu Gln Asp Ile Gly Asp Thr Leu Ser 
                245                 250                 255     


Arg Ala Glu Arg Ile Arg Ile Pro Glu Pro Trp Ile Thr Pro Pro Asp 
            260                 265                 270         


Leu Gln Glu Lys Ile His Ile Phe Ala Gln Lys Cys Leu Phe Leu Thr 
        275                 280                 285             


Glu Ser Leu Lys Gln Phe Thr Glu Lys Met Gln Ser Asp Met Glu Lys 
    290                 295                 300                 


Ile Gln Glu Leu Arg Glu Ala Gln Leu Tyr Ser Val Asp Val Thr Leu 
305                 310                 315                 320 


Asp Pro Asp Thr Ala Tyr Pro Ser Leu Ile Leu Ser Asp Asn Leu Arg 
                325                 330                 335     


Gln Val Arg Tyr Ser Tyr Leu Gln Gln Asp Leu Pro Asp Asn Pro Glu 
            340                 345                 350         


Arg Phe Asn Leu Phe Pro Cys Val Leu Gly Ser Pro Cys Phe Ile Ala 
        355                 360                 365             


Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Lys Ala Lys Trp Thr 
    370                 375                 380                 


Ile Gly Val Cys Glu Asp Ser Val Cys Arg Lys Gly Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Gln Asn Gly Phe Trp Ala Val Ser Leu Trp Tyr Gly Lys Glu 
                405                 410                 415     


Tyr Trp Ala Leu Thr Ser Pro Met Thr Ala Leu Pro Leu Arg Thr Pro 
            420                 425                 430         


Leu Gln Arg Val Gly Ile Phe Leu Asp Tyr Asp Ala Gly Glu Val Ser 
        435                 440                 445             


Phe Tyr Asn Val Thr Glu Arg Cys His Thr Phe Thr Phe Ser His Ala 
    450                 455                 460                 


Thr Phe Cys Gly Pro Val Arg Pro Tyr Phe Ser Leu Ser Tyr Ser Gly 
465                 470                 475                 480 


Gly Lys Ser Ala Ala Pro Leu Ile Ile Cys Pro Met Ser Gly Ile Asp 
                485                 490                 495     


Gly Phe Ser Gly His Val Gly Asn His Gly His Ser Met Glu Thr Ser 
            500                 505                 510         


Pro 
    


<210>  1309
<211>  2704
<212>  DNA
<213>  Homosapiens

<400>  1309
gttttacgct gccgccggca tccgctcgga cgcggccacg ttgtcttgcg cgctttgccc     60

gcctggccct gggactctga ccctcggcta ccctttcctg ccccactagc gtggccgcga    120

gcctcggtga gccggccgta ttcccgctct cgcttagggg gcacaggcgc aggcatcggc    180

ccggccactc caagccttcg gtgcgcgggc gcgtctggga tacgggcccg ggaggcgccg    240

ccctccgtcc gcccggtgcc tctcaggaac agcgaaccgg agagagcgcc ggagagttgg    300

gctcagtgcg gagctcggcg ccggggccca tgcccgtgcg cccccgcagg ccggcgccat    360

ggcctccggg agtgtggccg agtgcctgca gcaggagacc acctgccccg tgtgcctgca    420

gtacttcgca gagcccatga tgctcgactg cggccataac atctgttgcg cgtgcctcgc    480

ccgctgctgg ggcacggcag agactaacgt gtcgtgcccg cagtgccggg agaccttccc    540

gcagaggcac atgcggccca accggcacct ggccaacgtg acccaactgg taaagcagct    600

gcgcaccgag cggccgtcgg ggcccggcgg cgagatgggc gtgtgcgaga agcaccgcga    660

gcccctgaag ctgtactgcg aggaggacca gatgcccatc tgcgtggtgt gcgaccgctc    720

ccgcgagcac cgcggccaca gcgtgctgcc gctcgaggag gcggtggagg gcttcaagga    780

gcaaatccag aaccagctcg accatttaaa aagagtgaaa gatttaaaga agagacgtcg    840

ggcccagggg gaacaggcac gagctgaact cttgagccta acccagatgg agagggagaa    900

gattgtttgg gagtttgagc agctgtatca ctccttaaag gagcatgagt atcgcctcct    960

ggcccgcctt gaggagctag acttggccat ctacaatagc atcaatggtg ccatcaccca   1020

gttctcttgc aacatctccc acctcagcag cctgatcgct cagctagaag agaagcagca   1080

gcagcccacc agggagctcc tgcaggacat tggggacaca ttgagcaggg ctgaaagaat   1140

caggattcct gaaccttgga tcacacctcc agatttgcaa gagaaaatcc acatttttgc   1200

ccaaaaatgt ctattcttga cggagagtct aaagcagttc acagaaaaaa tgcagtcaga   1260

tatggagaaa atccaagaat taagagaggc tcagttatac tcagtggacg tgactctgga   1320

cccagacacg gcctacccca gcctgatcct ctctgataat ctgcggcaag tgcggtacag   1380

ttacctccaa caggacctgc ctgacaaccc cgagaggtct ccttctacaa cgtgacagag   1440

aggtgtcaca ccttcacttt ctctcatgct accttttgtg ggcctgtccg gccctacttc   1500

agtctgagtt actcgggagg gaaaagtgca gctcctctga tcatctgccc catgagtggg   1560

atagatgggt tttctggcca tgttgggaat catggtcatt ccatggagac ctccccttga   1620

ggaggtgaat tcaggccaaa agggctgttg gctgtaatcc tacgccaggc acaaggcatc   1680

ttgttgcctt gccacgtcct gtcacagctg ggtatcctta ccatgttcca cgcccttgca   1740

gtgggagaca ggatgtccat gttctctacc atccttttcc ttcccatgca gattgtgaaa   1800

tgtaatgaga tgtatcaaga catcctagaa ataaaaacca gatgtccacc tccagtgttt   1860

catactttct ggttttacac atcgctggag ggataaagag tatggataat ctttggattt   1920

ggagagccgt tcaagatact tccagcttct tggctcagcc tggcttcctc tggttcagcc   1980

ccacataatg attatggcta tttgctgtca tttctgggct agggctcctt tctaacaacc   2040

tagactggaa taaggccctg tcagcatggc tccctttatc ccagttttcc gtctgggaac   2100

agtacctctg cccctgattc ccaatgtgcc atagttttat taactccatt aaagaagcct   2160

gtatgtgttt tggttagtta cagttatttt acaataatgg tgggtaatgg ccccacctct   2220

gttatgagat aatgttctaa tcaatgtctc tgcctttgta tcttttctga gggctttgtc   2280

tgttctcttc attctaatga aaggtgtatt ctagtgctgg gtgcatatca tccaggataa   2340

tattctgccc aactccatcc tctgttacta gatcccttac cagtcacatt tgtggactgg   2400

tggccagtcg tataccatcc ctggaaggat tctgggacaa tattccaggg attcattgac   2460

ttcttggctc cttttctcca tttcctttgg gggaaggggg aattgaccat gcttaagtgc   2520

atcctatcaa ggggcagctc cgtccccatg gccattggat catgagacac tcgaagtcag   2580

aaggctgggg cagatcactt caagcaagcc cccatgatgg ttctcagtcc tgcttctctg   2640

tgggtacgtg cccctctgtt taaaaataaa ctgaatatgg atgtttaaaa aaaaaaaaaa   2700

aaaa                                                                2704


<210>  1310
<211>  358
<212>  PRT
<213>  Homosapiens

<400>  1310

Met Ala Ser Gly Ser Val Ala Glu Cys Leu Gln Gln Glu Thr Thr Cys 
1               5                   10                  15      


Pro Val Cys Leu Gln Tyr Phe Ala Glu Pro Met Met Leu Asp Cys Gly 
            20                  25                  30          


His Asn Ile Cys Cys Ala Cys Leu Ala Arg Cys Trp Gly Thr Ala Glu 
        35                  40                  45              


Thr Asn Val Ser Cys Pro Gln Cys Arg Glu Thr Phe Pro Gln Arg His 
    50                  55                  60                  


Met Arg Pro Asn Arg His Leu Ala Asn Val Thr Gln Leu Val Lys Gln 
65                  70                  75                  80  


Leu Arg Thr Glu Arg Pro Ser Gly Pro Gly Gly Glu Met Gly Val Cys 
                85                  90                  95      


Glu Lys His Arg Glu Pro Leu Lys Leu Tyr Cys Glu Glu Asp Gln Met 
            100                 105                 110         


Pro Ile Cys Val Val Cys Asp Arg Ser Arg Glu His Arg Gly His Ser 
        115                 120                 125             


Val Leu Pro Leu Glu Glu Ala Val Glu Gly Phe Lys Glu Gln Ile Gln 
    130                 135                 140                 


Asn Gln Leu Asp His Leu Lys Arg Val Lys Asp Leu Lys Lys Arg Arg 
145                 150                 155                 160 


Arg Ala Gln Gly Glu Gln Ala Arg Ala Glu Leu Leu Ser Leu Thr Gln 
                165                 170                 175     


Met Glu Arg Glu Lys Ile Val Trp Glu Phe Glu Gln Leu Tyr His Ser 
            180                 185                 190         


Leu Lys Glu His Glu Tyr Arg Leu Leu Ala Arg Leu Glu Glu Leu Asp 
        195                 200                 205             


Leu Ala Ile Tyr Asn Ser Ile Asn Gly Ala Ile Thr Gln Phe Ser Cys 
    210                 215                 220                 


Asn Ile Ser His Leu Ser Ser Leu Ile Ala Gln Leu Glu Glu Lys Gln 
225                 230                 235                 240 


Gln Gln Pro Thr Arg Glu Leu Leu Gln Asp Ile Gly Asp Thr Leu Ser 
                245                 250                 255     


Arg Ala Glu Arg Ile Arg Ile Pro Glu Pro Trp Ile Thr Pro Pro Asp 
            260                 265                 270         


Leu Gln Glu Lys Ile His Ile Phe Ala Gln Lys Cys Leu Phe Leu Thr 
        275                 280                 285             


Glu Ser Leu Lys Gln Phe Thr Glu Lys Met Gln Ser Asp Met Glu Lys 
    290                 295                 300                 


Ile Gln Glu Leu Arg Glu Ala Gln Leu Tyr Ser Val Asp Val Thr Leu 
305                 310                 315                 320 


Asp Pro Asp Thr Ala Tyr Pro Ser Leu Ile Leu Ser Asp Asn Leu Arg 
                325                 330                 335     


Gln Val Arg Tyr Ser Tyr Leu Gln Gln Asp Leu Pro Asp Asn Pro Glu 
            340                 345                 350         


Arg Ser Pro Ser Thr Thr 
        355             


<210>  1311
<211>  2698
<212>  DNA
<213>  Homosapiens

<400>  1311
agcatccatt catatattca ttcagtcagc taatttttaa tccagcacat actattgcaa     60

gcgctgtttt aggcgttgag aatacaactg tgaacaagac gacaaaaatt cctgccctca    120

tggagcctaa gagcctagat tttagcgaag gtagaaccac cgtaaacaat gtatatatta    180

ataagtaact tatgcaccat actggaaaat tataaagtgc tatagaggaa aagaagaatt    240

catgtaaagc aagggaaaca agatgtgaga tcacagcggt ttagtgttgc taatgaaccc    300

caaatccagg gcagtgtttg acacattaag ccaaacagta gcggcactgt gggtcaagaa    360

gggccctttg gctggcacca ccaaaacatg tgttctccaa aggaggctgg catcaactgg    420

agccacttca cagcttgttt gagaactgga tctgaccagt aggaagaaac caggacagca    480

gtggaagact gttaaagaaa cctgagtaaa aagatgcagg aggttgtgct gttggatgag    540

agttcaggac caccaagcca gctgctttgg acccgccagg atacccagct ccctcaggaa    600

agcgctctat tacctgctcc atatcctgcc ttcactaaag atggaagcca aggaaacctg    660

ccgcaagcag atatcacact aatgagccag gcccaagagt cagtgacatt tgaggatgta    720

gctgtgaact tcactaacag ggagtggcag tgtctgacct acgctcaaag gcatctctat    780

aaggatgtga tgttggaaaa ttatgggaac atggtatcac ttggatttcc atttcctaaa    840

cctcctttaa tctctcatct ggagcgagaa gtagacccct gtgtgcagga tccacaggac    900

agggagtccc taagctgctc ctacccagtg tcagctgaca agatgtggcc tgagaatgaa    960

aaggcaagtt cacaacaaga gatttttgaa aatggagaag cctactggat gaaatttaac   1020

agtctcctaa aagttgattc ccgggatcct aaggttagag aagtttgtgt tcaggatgtc   1080

aaattagaga atcaatggga aacatctata agggagaaac tgagagaaga gaaagaaggc   1140

tctgaggaag tgacctgcaa aaaaggaaag aaccagaaag tgcttagtaa aaacttgaat   1200

ccaaactcaa aacatagtca atgtaataaa gttcttatag cacagaaact ccatgaatgt   1260

gccaggtgtg gcaaaaactt cagttggcac tcagatctaa ttctccatga gcaaattcat   1320

tctggtgaga aaccccatgt gtgtaatgag tgtgggaaag cattcaagac cagaaatcag   1380

ctttctatgc accggataat ccacacaggg gagaaacctt ttaattgcac ccagtgtggg   1440

aaggctttca acagtagatc agctctttgc cgacataaaa aaacccacag tggggagaag   1500

cctcacgagt gcagggactg tgggaaggcc ttcaagacca ggaaccgtct ctgtatgcat   1560

cagcttatcc acaccgggga gaagccttac aaatgtaact gctgtgggaa ggccttccag   1620

tttaagcatt cccttaccat ccatggcaga atccacactg gggagaagcc atatgaatgt   1680

gaggagtgcg ggaaggcctt cagtgggagt tcagacctca ccaaacacat aagaatccac   1740

actggggaac gaccttatga gtgcagcaag tgtggaaggg ccttcagtcg gagctcagac   1800

ctaagcaaac acaaacgaat ccatactcgg gagaaacact atgggtgtcc ccagtgtgga   1860

aaagacttca gcatcaaggc agaactcacc aaacacagaa ggatccacac tgaagagaaa   1920

cgttacaggt gtgaggagtg tgggaaagcc tttcgtcata actgtaagcg cagggctcat   1980

gaacgagagc atacagggga gaagccctat caatgcaggg attgtgggaa aaccttccaa   2040

gataagcact gccttaccat ccatcagaga atccacactg gagagaaacc ttacaaatgt   2100

ttagagtgtg ggaaagcttt cagtgggaag tcaaacttga ccaatcatcg aagaattcac   2160

actggagaga agcctcacaa atgtgaggta tgtggaatgg ccttccatca tagttcagtc   2220

ctgaggcagc acaaaagaat ccacactggt gagaagccat acacctgcag tgagtgtggc   2280

acgtccttcc gtcagggctc agctctgatt ggacataagc gagttcatac tggggagaaa   2340

ccttatgaat gtgaggaatg tggaaaagct tttagagtga gctcaaatct tactggacat   2400

aagaaaagaa aacatcaagt atggagtacc catgaacttg atgggagtag gaaatccctc   2460

tctccagtga ctgtttctca gacctcagta gtcagtattt tgaccagtgc ctgagtataa   2520

cgattctggt gttactttct gtttttccta cctcttaggc tggtccttct gtctcttata   2580

ttagttattc ctgatttcct gacccttaat tgtgagattc cccaaagaca ttgtccttta   2640

ccttcttatt cactattttt tcagtgagca catttacttc caagagttta tcaatcac     2698


<210>  1312
<211>  666
<212>  PRT
<213>  Homosapiens

<400>  1312

Met Gln Glu Val Val Leu Leu Asp Glu Ser Ser Gly Pro Pro Ser Gln 
1               5                   10                  15      


Leu Leu Trp Thr Arg Gln Asp Thr Gln Leu Pro Gln Glu Ser Ala Leu 
            20                  25                  30          


Leu Pro Ala Pro Tyr Pro Ala Phe Thr Lys Asp Gly Ser Gln Gly Asn 
        35                  40                  45              


Leu Pro Gln Ala Asp Ile Thr Leu Met Ser Gln Ala Gln Glu Ser Val 
    50                  55                  60                  


Thr Phe Glu Asp Val Ala Val Asn Phe Thr Asn Arg Glu Trp Gln Cys 
65                  70                  75                  80  


Leu Thr Tyr Ala Gln Arg His Leu Tyr Lys Asp Val Met Leu Glu Asn 
                85                  90                  95      


Tyr Gly Asn Met Val Ser Leu Gly Phe Pro Phe Pro Lys Pro Pro Leu 
            100                 105                 110         


Ile Ser His Leu Glu Arg Glu Val Asp Pro Cys Val Gln Asp Pro Gln 
        115                 120                 125             


Asp Arg Glu Ser Leu Ser Cys Ser Tyr Pro Val Ser Ala Asp Lys Met 
    130                 135                 140                 


Trp Pro Glu Asn Glu Lys Ala Ser Ser Gln Gln Glu Ile Phe Glu Asn 
145                 150                 155                 160 


Gly Glu Ala Tyr Trp Met Lys Phe Asn Ser Leu Leu Lys Val Asp Ser 
                165                 170                 175     


Arg Asp Pro Lys Val Arg Glu Val Cys Val Gln Asp Val Lys Leu Glu 
            180                 185                 190         


Asn Gln Trp Glu Thr Ser Ile Arg Glu Lys Leu Arg Glu Glu Lys Glu 
        195                 200                 205             


Gly Ser Glu Glu Val Thr Cys Lys Lys Gly Lys Asn Gln Lys Val Leu 
    210                 215                 220                 


Ser Lys Asn Leu Asn Pro Asn Ser Lys His Ser Gln Cys Asn Lys Val 
225                 230                 235                 240 


Leu Ile Ala Gln Lys Leu His Glu Cys Ala Arg Cys Gly Lys Asn Phe 
                245                 250                 255     


Ser Trp His Ser Asp Leu Ile Leu His Glu Gln Ile His Ser Gly Glu 
            260                 265                 270         


Lys Pro His Val Cys Asn Glu Cys Gly Lys Ala Phe Lys Thr Arg Asn 
        275                 280                 285             


Gln Leu Ser Met His Arg Ile Ile His Thr Gly Glu Lys Pro Phe Asn 
    290                 295                 300                 


Cys Thr Gln Cys Gly Lys Ala Phe Asn Ser Arg Ser Ala Leu Cys Arg 
305                 310                 315                 320 


His Lys Lys Thr His Ser Gly Glu Lys Pro His Glu Cys Arg Asp Cys 
                325                 330                 335     


Gly Lys Ala Phe Lys Thr Arg Asn Arg Leu Cys Met His Gln Leu Ile 
            340                 345                 350         


His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Cys Cys Gly Lys Ala Phe 
        355                 360                 365             


Gln Phe Lys His Ser Leu Thr Ile His Gly Arg Ile His Thr Gly Glu 
    370                 375                 380                 


Lys Pro Tyr Glu Cys Glu Glu Cys Gly Lys Ala Phe Ser Gly Ser Ser 
385                 390                 395                 400 


Asp Leu Thr Lys His Ile Arg Ile His Thr Gly Glu Arg Pro Tyr Glu 
                405                 410                 415     


Cys Ser Lys Cys Gly Arg Ala Phe Ser Arg Ser Ser Asp Leu Ser Lys 
            420                 425                 430         


His Lys Arg Ile His Thr Arg Glu Lys His Tyr Gly Cys Pro Gln Cys 
        435                 440                 445             


Gly Lys Asp Phe Ser Ile Lys Ala Glu Leu Thr Lys His Arg Arg Ile 
    450                 455                 460                 


His Thr Glu Glu Lys Arg Tyr Arg Cys Glu Glu Cys Gly Lys Ala Phe 
465                 470                 475                 480 


Arg His Asn Cys Lys Arg Arg Ala His Glu Arg Glu His Thr Gly Glu 
                485                 490                 495     


Lys Pro Tyr Gln Cys Arg Asp Cys Gly Lys Thr Phe Gln Asp Lys His 
            500                 505                 510         


Cys Leu Thr Ile His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
        515                 520                 525             


Cys Leu Glu Cys Gly Lys Ala Phe Ser Gly Lys Ser Asn Leu Thr Asn 
    530                 535                 540                 


His Arg Arg Ile His Thr Gly Glu Lys Pro His Lys Cys Glu Val Cys 
545                 550                 555                 560 


Gly Met Ala Phe His His Ser Ser Val Leu Arg Gln His Lys Arg Ile 
                565                 570                 575     


His Thr Gly Glu Lys Pro Tyr Thr Cys Ser Glu Cys Gly Thr Ser Phe 
            580                 585                 590         


Arg Gln Gly Ser Ala Leu Ile Gly His Lys Arg Val His Thr Gly Glu 
        595                 600                 605             


Lys Pro Tyr Glu Cys Glu Glu Cys Gly Lys Ala Phe Arg Val Ser Ser 
    610                 615                 620                 


Asn Leu Thr Gly His Lys Lys Arg Lys His Gln Val Trp Ser Thr His 
625                 630                 635                 640 


Glu Leu Asp Gly Ser Arg Lys Ser Leu Ser Pro Val Thr Val Ser Gln 
                645                 650                 655     


Thr Ser Val Val Ser Ile Leu Thr Ser Ala 
            660                 665     


<210>  1313
<211>  983
<212>  DNA
<213>  Homosapiens

<400>  1313
gatttagaca ttgaaggact atggaccaaa gcaattatag ttctttacat ggttttattc     60

tgcttggctt ctctaaccat ccaaaaatgg agatgatcct gtcaggagtt gtcgccatct    120

tctacttaat tacattggtg ggtaacacag ccatcattct tgcatctctc ctggattccc    180

agcttcatac accaatgtac tttttcctca gaaatttatc tttcctagat ctatgtttca    240

caaccagcat catccctcag atgctggtca acttgtgggg acctgataag accatcagct    300

atgtgggttg tatcatccaa ctctatgttt acatgtggtt gggctcagtt gagtgccttc    360

tcctggctgt tatgtcctat gatcgtttta cagctatatg taagcccttg cattattttg    420

tagtcatgaa cccacatcta tgtctaaaga tgattatcat gatctggagt attagtttgg    480

ccaattctgt agtattatgt acactcactc tgaatttgcc cacatgtgga aacaacattc    540

tggatcattt cttgtgtgag ttgccagctc tggtcaagat agcttgtgta gacaccacaa    600

cagttgaaat gtctgttttc gctttaggca ttataattgt cctcacacct ctcatcctta    660

ttcttatatc ctatggctac attgccaaag ctgtgctgag aacgaagtca aaagcaagcc    720

agcgaaaagc aatgaatacc tgtggatctc atcttactgt agtgtctatg ttctatggaa    780

ctattatcta catgtacctg caaccaggta acagggcttc caaagaccag ggcaagttcc    840

tcaccctctt ttacaccgtc atcactccaa gtctcaaccc gctcatttac accttaagaa    900

ataaggacat gaaggatgcc ctgaagaaac tgatgagatt tcaccacaaa tctacaaaaa    960

taaagaggaa ttgcaagtca tag                                            983


<210>  1314
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  1314

Met Asp Gln Ser Asn Tyr Ser Ser Leu His Gly Phe Ile Leu Leu Gly 
1               5                   10                  15      


Phe Ser Asn His Pro Lys Met Glu Met Ile Leu Ser Gly Val Val Ala 
            20                  25                  30          


Ile Phe Tyr Leu Ile Thr Leu Val Gly Asn Thr Ala Ile Ile Leu Ala 
        35                  40                  45              


Ser Leu Leu Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Arg 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Ile Ile Pro Gln 
65                  70                  75                  80  


Met Leu Val Asn Leu Trp Gly Pro Asp Lys Thr Ile Ser Tyr Val Gly 
                85                  90                  95      


Cys Ile Ile Gln Leu Tyr Val Tyr Met Trp Leu Gly Ser Val Glu Cys 
            100                 105                 110         


Leu Leu Leu Ala Val Met Ser Tyr Asp Arg Phe Thr Ala Ile Cys Lys 
        115                 120                 125             


Pro Leu His Tyr Phe Val Val Met Asn Pro His Leu Cys Leu Lys Met 
    130                 135                 140                 


Ile Ile Met Ile Trp Ser Ile Ser Leu Ala Asn Ser Val Val Leu Cys 
145                 150                 155                 160 


Thr Leu Thr Leu Asn Leu Pro Thr Cys Gly Asn Asn Ile Leu Asp His 
                165                 170                 175     


Phe Leu Cys Glu Leu Pro Ala Leu Val Lys Ile Ala Cys Val Asp Thr 
            180                 185                 190         


Thr Thr Val Glu Met Ser Val Phe Ala Leu Gly Ile Ile Ile Val Leu 
        195                 200                 205             


Thr Pro Leu Ile Leu Ile Leu Ile Ser Tyr Gly Tyr Ile Ala Lys Ala 
    210                 215                 220                 


Val Leu Arg Thr Lys Ser Lys Ala Ser Gln Arg Lys Ala Met Asn Thr 
225                 230                 235                 240 


Cys Gly Ser His Leu Thr Val Val Ser Met Phe Tyr Gly Thr Ile Ile 
                245                 250                 255     


Tyr Met Tyr Leu Gln Pro Gly Asn Arg Ala Ser Lys Asp Gln Gly Lys 
            260                 265                 270         


Phe Leu Thr Leu Phe Tyr Thr Val Ile Thr Pro Ser Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Thr Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys Lys Leu 
    290                 295                 300                 


Met Arg Phe His His Lys Ser Thr Lys Ile Lys Arg Asn Cys Lys Ser 
305                 310                 315                 320 


<210>  1315
<211>  942
<212>  DNA
<213>  Homosapiens

<400>  1315
atgaattggg aaaatgagag ctccccaaaa gagtttatac tacttggctt ctcagatagg     60

gcttggctac aaatgcccct ttttgtggtc ctgttaatat catacacaat caccatattt    120

ggcaatgtgt ccatcatgat ggtgtgcatt ctggatccca aacttcatac tcccatgtat    180

ttctttctca ctaatctctc catcttagat ctctgctata ccacaactac agtccctcat    240

atgttggtaa atattggttg caacaaaaag accatcagct atgctggctg tgtggcccac    300

ctcatcatct tcctggccct aggtgctaca gagtgtctcc ttctggctgt tatgtccttt    360

gacagatatg tggctgtttg cagacccctc cactatgtag tcatcatgaa ttattggttc    420

tgcctaagga tggcagcctt ctcatggctc attggtttcg gcaactcagt gctgcagtct    480

tccttgactc ttaacatgcc acgctgtggt caccaggaag tggaccactt tttctgtgag    540

gtgcctgcac ttctcaagtt gtcatgtgct gacacaaagc ctattgaggc tgagctcttc    600

ttctttagtg tactaattct tctaattcca gtgacattga tcctcatctc ctatggcttc    660

atagctcaag cagtattaaa aatcaggtca gcagaaggac ggcaaaaagc atttgggaca    720

tgtgggtccc acatgattgt ggtgtccctc ttttatggaa cagccattta tatgtatctt    780

caaccacctt catccacctc taaggactgg ggaaagatgg tttccctctt ctatggaatc    840

atcacatcca tgttgaactc cctcatctac agccttagaa ataaagatat gaaggaggcc    900

ttcaagaggc tgatgccaag aatctttttc tgtaagaaat aa                       942


<210>  1316
<211>  313
<212>  PRT
<213>  Homosapiens

<400>  1316

Met Asn Trp Glu Asn Glu Ser Ser Pro Lys Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Phe Ser Asp Arg Ala Trp Leu Gln Met Pro Leu Phe Val Val Leu Leu 
            20                  25                  30          


Ile Ser Tyr Thr Ile Thr Ile Phe Gly Asn Val Ser Ile Met Met Val 
        35                  40                  45              


Cys Ile Leu Asp Pro Lys Leu His Thr Pro Met Tyr Phe Phe Leu Thr 
    50                  55                  60                  


Asn Leu Ser Ile Leu Asp Leu Cys Tyr Thr Thr Thr Thr Val Pro His 
65                  70                  75                  80  


Met Leu Val Asn Ile Gly Cys Asn Lys Lys Thr Ile Ser Tyr Ala Gly 
                85                  90                  95      


Cys Val Ala His Leu Ile Ile Phe Leu Ala Leu Gly Ala Thr Glu Cys 
            100                 105                 110         


Leu Leu Leu Ala Val Met Ser Phe Asp Arg Tyr Val Ala Val Cys Arg 
        115                 120                 125             


Pro Leu His Tyr Val Val Ile Met Asn Tyr Trp Phe Cys Leu Arg Met 
    130                 135                 140                 


Ala Ala Phe Ser Trp Leu Ile Gly Phe Gly Asn Ser Val Leu Gln Ser 
145                 150                 155                 160 


Ser Leu Thr Leu Asn Met Pro Arg Cys Gly His Gln Glu Val Asp His 
                165                 170                 175     


Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Ala Asp Thr 
            180                 185                 190         


Lys Pro Ile Glu Ala Glu Leu Phe Phe Phe Ser Val Leu Ile Leu Leu 
        195                 200                 205             


Ile Pro Val Thr Leu Ile Leu Ile Ser Tyr Gly Phe Ile Ala Gln Ala 
    210                 215                 220                 


Val Leu Lys Ile Arg Ser Ala Glu Gly Arg Gln Lys Ala Phe Gly Thr 
225                 230                 235                 240 


Cys Gly Ser His Met Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Ile 
                245                 250                 255     


Tyr Met Tyr Leu Gln Pro Pro Ser Ser Thr Ser Lys Asp Trp Gly Lys 
            260                 265                 270         


Met Val Ser Leu Phe Tyr Gly Ile Ile Thr Ser Met Leu Asn Ser Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Glu Ala Phe Lys Arg Leu 
    290                 295                 300                 


Met Pro Arg Ile Phe Phe Cys Lys Lys 
305                 310             


<210>  1317
<211>  936
<212>  DNA
<213>  Homosapiens

<400>  1317
atgaatgatg atggaaaagt caatgctagc tctgaggggt actttatttt agttggattt     60

tctaattggc ctcatctgga agtagttatc tttgtggttg tcttgatctt ctacttgatg    120

acactgatag gaaacctgtt catcatcatc ctgtcatacc tggactccca tctgcacaca    180

ccaatgtact tcttcctttc aaacctctca tttctggatc tctgctacac caccagctct    240

atccctcagt tgctggtcaa tctctggggc ccggaaaaga ccatctctta tgctggttgc    300

atgattcaac tttactttgt tctcgcactg ggaaccgcag agtgtgtcct actggtggtg    360

atgtcctatg accgttatgc agctgtgtgt agacctttgc attacactgt cctcatgcac    420

cctcgtttct gccacctgct ggctgtggct tcttgggtaa gtggttttac caactcagca    480

cttcattcct ccttcacctt ctgggtacct ctgtgtggac accgccaagt agatcacttt    540

ttctgtgaag ttccagcact tctgcgatta tcgtgtgttg atacccatgt caatgagctg    600

accctcatga tcacaagctc catatttgtt ctcatacctc tcatcctcat tctcacttct    660

tatggtgcca tcgtccaagc tgtactgagg atgcagtcaa ccactgggct tcagaaagtg    720

tttggaacat gtggagctca tcttatggct gtatctctct ttttcattcc ggccatgtgc    780

atatatctcc agccaccatc aggaaattct caagatcaag gcaagttcat tgccctcttt    840

tatactgttg tcacacctag tcttaaccct ctaatctaca ccctcagaaa caaagttgta    900

agaggggcag tgaagagact aatggggtgg gaatga                              936


<210>  1318
<211>  311
<212>  PRT
<213>  Homosapiens

<400>  1318

Met Asn Asp Asp Gly Lys Val Asn Ala Ser Ser Glu Gly Tyr Phe Ile 
1               5                   10                  15      


Leu Val Gly Phe Ser Asn Trp Pro His Leu Glu Val Val Ile Phe Val 
            20                  25                  30          


Val Val Leu Ile Phe Tyr Leu Met Thr Leu Ile Gly Asn Leu Phe Ile 
        35                  40                  45              


Ile Ile Leu Ser Tyr Leu Asp Ser His Leu His Thr Pro Met Tyr Phe 
    50                  55                  60                  


Phe Leu Ser Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Ser Ser 
65                  70                  75                  80  


Ile Pro Gln Leu Leu Val Asn Leu Trp Gly Pro Glu Lys Thr Ile Ser 
                85                  90                  95      


Tyr Ala Gly Cys Met Ile Gln Leu Tyr Phe Val Leu Ala Leu Gly Thr 
            100                 105                 110         


Ala Glu Cys Val Leu Leu Val Val Met Ser Tyr Asp Arg Tyr Ala Ala 
        115                 120                 125             


Val Cys Arg Pro Leu His Tyr Thr Val Leu Met His Pro Arg Phe Cys 
    130                 135                 140                 


His Leu Leu Ala Val Ala Ser Trp Val Ser Gly Phe Thr Asn Ser Ala 
145                 150                 155                 160 


Leu His Ser Ser Phe Thr Phe Trp Val Pro Leu Cys Gly His Arg Gln 
                165                 170                 175     


Val Asp His Phe Phe Cys Glu Val Pro Ala Leu Leu Arg Leu Ser Cys 
            180                 185                 190         


Val Asp Thr His Val Asn Glu Leu Thr Leu Met Ile Thr Ser Ser Ile 
        195                 200                 205             


Phe Val Leu Ile Pro Leu Ile Leu Ile Leu Thr Ser Tyr Gly Ala Ile 
    210                 215                 220                 


Val Gln Ala Val Leu Arg Met Gln Ser Thr Thr Gly Leu Gln Lys Val 
225                 230                 235                 240 


Phe Gly Thr Cys Gly Ala His Leu Met Ala Val Ser Leu Phe Phe Ile 
                245                 250                 255     


Pro Ala Met Cys Ile Tyr Leu Gln Pro Pro Ser Gly Asn Ser Gln Asp 
            260                 265                 270         


Gln Gly Lys Phe Ile Ala Leu Phe Tyr Thr Val Val Thr Pro Ser Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Val Val Arg Gly Ala Val 
    290                 295                 300                 


Lys Arg Leu Met Gly Trp Glu 
305                 310     


<210>  1319
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  1319
atgatgatta aaaaaaatgc aagttcggaa gacttcttta ttctacttgg attttctaat     60

tggcctcagc tggaagtagt tctctttgtg gttatcttga tcttctacct gatgacactg    120

acaggaaacc tgttcatcat catcctgtca tacgtggact cccatctcca cacaccaatg    180

tacttcttcc tttcaaacct ctcatttctg gatctctgcc acaccaccag ctctatccct    240

cagttgctgg tgaatctccg gggcccggaa aagaccatct cgtatgctgg ttgcatggtt    300

caactttact ttgttcttgc actgggaatc gcagagtgtg tcctactggt ggtgatgtcg    360

tatgatcgtt atgtagctgt gtgtagacct ttgcattaca ctgtcctcat gcaccctcgt    420

ttctgccact tgttggctgc ggcttcttgg gtaattggtt ttactatctc agcacttcat    480

tcctccttta ctttctgggt acccctttgt ggacatcgcc tagtggatca cttcttctgt    540

gaagttccag cacttctgcg tttatcatgt gttgacaccc atgcaaatga gctgaccctc    600

atggtcatga gctccatttt tgttctcata cctctcattc tgattctcac tgcctatggt    660

gccattgccc gggctgtact gagcatgcaa tcaaccactg ggcttcagaa agtgtttagg    720

acatgtggag cccatcttat ggttgtatct ctctttttca ttccagtcat gtgcatgtat    780

ctccagccac catcagaaaa ttctcctgat cagggcaagt tcattgccct cttttatact    840

gttgtcacac cgagtcttaa tcctctaatc tacactctca gaaacaagca tgtaaaaggg    900

gcagcgaaga gactattggg gtgggagtgg gggaagtga                           939


<210>  1320
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  1320

Met Met Ile Lys Lys Asn Ala Ser Ser Glu Asp Phe Phe Ile Leu Leu 
1               5                   10                  15      


Gly Phe Ser Asn Trp Pro Gln Leu Glu Val Val Leu Phe Val Val Ile 
            20                  25                  30          


Leu Ile Phe Tyr Leu Met Thr Leu Thr Gly Asn Leu Phe Ile Ile Ile 
        35                  40                  45              


Leu Ser Tyr Val Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Ser Asn Leu Ser Phe Leu Asp Leu Cys His Thr Thr Ser Ser Ile Pro 
65                  70                  75                  80  


Gln Leu Leu Val Asn Leu Arg Gly Pro Glu Lys Thr Ile Ser Tyr Ala 
                85                  90                  95      


Gly Cys Met Val Gln Leu Tyr Phe Val Leu Ala Leu Gly Ile Ala Glu 
            100                 105                 110         


Cys Val Leu Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys 
        115                 120                 125             


Arg Pro Leu His Tyr Thr Val Leu Met His Pro Arg Phe Cys His Leu 
    130                 135                 140                 


Leu Ala Ala Ala Ser Trp Val Ile Gly Phe Thr Ile Ser Ala Leu His 
145                 150                 155                 160 


Ser Ser Phe Thr Phe Trp Val Pro Leu Cys Gly His Arg Leu Val Asp 
                165                 170                 175     


His Phe Phe Cys Glu Val Pro Ala Leu Leu Arg Leu Ser Cys Val Asp 
            180                 185                 190         


Thr His Ala Asn Glu Leu Thr Leu Met Val Met Ser Ser Ile Phe Val 
        195                 200                 205             


Leu Ile Pro Leu Ile Leu Ile Leu Thr Ala Tyr Gly Ala Ile Ala Arg 
    210                 215                 220                 


Ala Val Leu Ser Met Gln Ser Thr Thr Gly Leu Gln Lys Val Phe Arg 
225                 230                 235                 240 


Thr Cys Gly Ala His Leu Met Val Val Ser Leu Phe Phe Ile Pro Val 
                245                 250                 255     


Met Cys Met Tyr Leu Gln Pro Pro Ser Glu Asn Ser Pro Asp Gln Gly 
            260                 265                 270         


Lys Phe Ile Ala Leu Phe Tyr Thr Val Val Thr Pro Ser Leu Asn Pro 
        275                 280                 285             


Leu Ile Tyr Thr Leu Arg Asn Lys His Val Lys Gly Ala Ala Lys Arg 
    290                 295                 300                 


Leu Leu Gly Trp Glu Trp Gly Lys 
305                 310         


<210>  1321
<211>  966
<212>  DNA
<213>  Homosapiens

<400>  1321
atggtcaatt tgacttcaat gagtggattc cttcttatgg ggttttctga tgagcgtaag     60

cttcagattt tacatgcatt ggtatttctg gtgacatacc tgctggcctt gacaggcaac    120

ctcctcatta tcaccatcat taccgtggac cgtcgtctcc attcccccat gtattacttt    180

ttaaagcacc tctctcttct ggacctctgc ttcatctctg tcacagtccc ccagtccatt    240

gcaaattcac ttatgggcaa cggttacatt tctcttgttc agtgcattct tcaggttttc    300

ttcttcatag ctctggcctc atcagaagtg gccattctca cagtgatgtc ttatgacagg    360

tacgcagcaa tctgtcaacc acttcattat gagactatta tggatccccg tgcctgtagg    420

catgcagtga tagctgtgtg gattgctggg ggcctctctg ggctcatgca tgctgccatt    480

aacttctcca tacctctctg tgggaagaga gtcattcacc aattcttctg tgatgttcct    540

cagatgctga aactagcctg ttcttatgaa ttcattaatg agattgcact ggctgcattc    600

acaacgtctg cagcatttat ctgtttgatc tccattgtgc tctcctacat tcgcatcttc    660

tctacagtgc tgagaatccc atcagctgag ggccggacca aggtcttctc cacctgccta    720

ccacacctat ttgtagccac cttctttctt tcagctgcag gctttgagtt tctcagactg    780

ccttctgatt cctcatcgac tgtggacctt gtattctccg tattctatac tgtgatacct    840

ccaacactca atccagtcat ttatagctta cggaatgatt ccatgaaggc agcactgagg    900

aagatgctgt caaaggaaga gcttcctcag agaaaaatgt gcttaaaagc catgtttaaa    960

ctctga                                                               966


<210>  1322
<211>  321
<212>  PRT
<213>  Homosapiens

<400>  1322

Met Val Asn Leu Thr Ser Met Ser Gly Phe Leu Leu Met Gly Phe Ser 
1               5                   10                  15      


Asp Glu Arg Lys Leu Gln Ile Leu His Ala Leu Val Phe Leu Val Thr 
            20                  25                  30          


Tyr Leu Leu Ala Leu Thr Gly Asn Leu Leu Ile Ile Thr Ile Ile Thr 
        35                  40                  45              


Val Asp Arg Arg Leu His Ser Pro Met Tyr Tyr Phe Leu Lys His Leu 
    50                  55                  60                  


Ser Leu Leu Asp Leu Cys Phe Ile Ser Val Thr Val Pro Gln Ser Ile 
65                  70                  75                  80  


Ala Asn Ser Leu Met Gly Asn Gly Tyr Ile Ser Leu Val Gln Cys Ile 
                85                  90                  95      


Leu Gln Val Phe Phe Phe Ile Ala Leu Ala Ser Ser Glu Val Ala Ile 
            100                 105                 110         


Leu Thr Val Met Ser Tyr Asp Arg Tyr Ala Ala Ile Cys Gln Pro Leu 
        115                 120                 125             


His Tyr Glu Thr Ile Met Asp Pro Arg Ala Cys Arg His Ala Val Ile 
    130                 135                 140                 


Ala Val Trp Ile Ala Gly Gly Leu Ser Gly Leu Met His Ala Ala Ile 
145                 150                 155                 160 


Asn Phe Ser Ile Pro Leu Cys Gly Lys Arg Val Ile His Gln Phe Phe 
                165                 170                 175     


Cys Asp Val Pro Gln Met Leu Lys Leu Ala Cys Ser Tyr Glu Phe Ile 
            180                 185                 190         


Asn Glu Ile Ala Leu Ala Ala Phe Thr Thr Ser Ala Ala Phe Ile Cys 
        195                 200                 205             


Leu Ile Ser Ile Val Leu Ser Tyr Ile Arg Ile Phe Ser Thr Val Leu 
    210                 215                 220                 


Arg Ile Pro Ser Ala Glu Gly Arg Thr Lys Val Phe Ser Thr Cys Leu 
225                 230                 235                 240 


Pro His Leu Phe Val Ala Thr Phe Phe Leu Ser Ala Ala Gly Phe Glu 
                245                 250                 255     


Phe Leu Arg Leu Pro Ser Asp Ser Ser Ser Thr Val Asp Leu Val Phe 
            260                 265                 270         


Ser Val Phe Tyr Thr Val Ile Pro Pro Thr Leu Asn Pro Val Ile Tyr 
        275                 280                 285             


Ser Leu Arg Asn Asp Ser Met Lys Ala Ala Leu Arg Lys Met Leu Ser 
    290                 295                 300                 


Lys Glu Glu Leu Pro Gln Arg Lys Met Cys Leu Lys Ala Met Phe Lys 
305                 310                 315                 320 


Leu 
    


<210>  1323
<211>  1048
<212>  DNA
<213>  Homosapiens

<400>  1323
gtcatgctat tgcagcatat gattcatttt tataatctgg tcttctcttt gcccaattcc     60

tgaaaggaaa ccaggcgaca tcatggaaag aaagaatcaa acagctataa ctgaattcat    120

catcttggga ttctccaacc taaatgaatt gcagttttta ctattcacca tcttctttct    180

gacttatttc tgtactttgg gaggaaatat attaattatc ttgacgactg tgactgatcc    240

acacctgcat acacctatgt attattttct agggaacttg gcctttattg acatctgcta    300

caccaccagc aatgtccccc agatgatggt gcacctcctc tcaaagaaaa aaagcatttc    360

ttatgtgggg tgtgtggttc aactttttgc atttgttttc tttgtaggat cagagtgtct    420

cctactggca gcaatggcat atgatcgtta cattgcaatc tgcaatcctt taaggtattc    480

agttattctg agcaaggttc tatgcaatca attagcagcc tcatgctggg ctgctggttt    540

ccttaactca gtggtgcata cagtgttgac attctgcctg cccttctgtg gcaacaatca    600

gattaattac ttcttctgtg acatcccccc tttgctgatc ttgtcttgtg gaaacacttc    660

tgtcaatgag ttggcactgc tatccactgg ggtcttcatt ggttggactc ctttcctttg    720

tatcgtactt tcctacattt gcataatctc caccatcttg aggatccagt cctcagaggg    780

aagacgaaaa gccttttcta catgtgcctc ccacctggcc attgtctttc tcttttatgg    840

cagcgccatc tttacatatg tacggcccat ctcaacttac tcattaaaga aagataggtt    900

ggtttcagtg ttgtacagtg ttgttacccc catgctaaac cctataattt acacattgag    960

gaataaggac atcaaagaag ctgtcaaaac tatagggagc aagtggcagc caccaatttc   1020

ctctttggat agtaaactca cttattga                                      1048


<210>  1324
<211>  321
<212>  PRT
<213>  Homosapiens

<400>  1324

Met Glu Arg Lys Asn Gln Thr Ala Ile Thr Glu Phe Ile Ile Leu Gly 
1               5                   10                  15      


Phe Ser Asn Leu Asn Glu Leu Gln Phe Leu Leu Phe Thr Ile Phe Phe 
            20                  25                  30          


Leu Thr Tyr Phe Cys Thr Leu Gly Gly Asn Ile Leu Ile Ile Leu Thr 
        35                  40                  45              


Thr Val Thr Asp Pro His Leu His Thr Pro Met Tyr Tyr Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ala Phe Ile Asp Ile Cys Tyr Thr Thr Ser Asn Val Pro Gln 
65                  70                  75                  80  


Met Met Val His Leu Leu Ser Lys Lys Lys Ser Ile Ser Tyr Val Gly 
                85                  90                  95      


Cys Val Val Gln Leu Phe Ala Phe Val Phe Phe Val Gly Ser Glu Cys 
            100                 105                 110         


Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Ser Val Ile Leu Ser Lys Val Leu Cys Asn Gln Leu 
    130                 135                 140                 


Ala Ala Ser Cys Trp Ala Ala Gly Phe Leu Asn Ser Val Val His Thr 
145                 150                 155                 160 


Val Leu Thr Phe Cys Leu Pro Phe Cys Gly Asn Asn Gln Ile Asn Tyr 
                165                 170                 175     


Phe Phe Cys Asp Ile Pro Pro Leu Leu Ile Leu Ser Cys Gly Asn Thr 
            180                 185                 190         


Ser Val Asn Glu Leu Ala Leu Leu Ser Thr Gly Val Phe Ile Gly Trp 
        195                 200                 205             


Thr Pro Phe Leu Cys Ile Val Leu Ser Tyr Ile Cys Ile Ile Ser Thr 
    210                 215                 220                 


Ile Leu Arg Ile Gln Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Ala Ile Val Phe Leu Phe Tyr Gly Ser Ala Ile 
                245                 250                 255     


Phe Thr Tyr Val Arg Pro Ile Ser Thr Tyr Ser Leu Lys Lys Asp Arg 
            260                 265                 270         


Leu Val Ser Val Leu Tyr Ser Val Val Thr Pro Met Leu Asn Pro Ile 
        275                 280                 285             


Ile Tyr Thr Leu Arg Asn Lys Asp Ile Lys Glu Ala Val Lys Thr Ile 
    290                 295                 300                 


Gly Ser Lys Trp Gln Pro Pro Ile Ser Ser Leu Asp Ser Lys Leu Thr 
305                 310                 315                 320 


Tyr 
    


<210>  1325
<211>  1869
<212>  DNA
<213>  Homosapiens

<400>  1325
agcaatggag aatgtcacta caatgaatga gtttcttcta cttggcctga ctggtgttca     60

ggagctgcag cctttcttct ttgggatttt cttaatcatt tacctgataa acttgattgg    120

aaatggatct atattggtga tggttgtttt ggaaccacaa ctccactccc ctatgtattt    180

ttttctggga aacctttctt gtctggatat ttcttattct tcagtgacac tgcccaagct    240

gctcgtaaac ctcgtgtgca gtcgcagggc tatatctttt ctaggctgta tcacccagct    300

acacttcttc cactttttgg gaagcacaga ggccatttta ctggctatca tggcctttga    360

ccgttttgtt gccatctgca atcctcttcg ctacactgtc atcatgaacc cccaggtgtg    420

tattctgttg gcagctgcgg cctggctcat cagcttcttt tacgctctga tgcattctgt    480

catgactgca cacctgagtt tttgtggctc tcagaaactc aatcacttct tctacgatgt    540

caagccgctc ttagaattgg cctgtagtga cacattactc aatcaatggc ttctttccat    600

tgtcacaggc agcatatcca tgggagcttt ctttctgact cttctctcct gcttctatgt    660

aattggcttc cttctgttta agaacaggtc ctgcagaata ctccacaagg ctctgtccac    720

ttgtgcctcc cattttatgg tggtatgtct tttctatgga cctgtgggct tcacatatat    780

tcgtcctgct tcagccacct ccatgattca ggaccggata atggccatca tgtatagcgc    840

cgtcacccct gtactgaatc cactaatcta cacccttagg aacaaagaag tgatgatggc    900

tctgaagaaa atctttggta ggaagttgtt taaagactgg cagcaacacc actaggacta    960

atgagggata tctgatttct attaagactg atttccatca cttcactgta agaaatgatt   1020

tgtttacctg gtttatattt ttctttcaaa aattttgagc acatattata ttaggcagtg   1080

tagtaggttc aagaaacaca ggagcaagca aaacaaattc cataatgtca tcaaacataa   1140

agtttaatgt gatggaggcc ccaaataacc aaacgcgtaa gtacatatgt caggataatt   1200

cggtggcaag gagaactaag gaggtaggaa gtatggggag ggttagagta ggaatctgct   1260

gtgtaaaaaa gaatgtggca tttctcctag gacaaaaacc tttggaattt tccaagtaat   1320

agaagtatct tactgaaatt ccatatgaga taatctttat ttttgcctat tttttttcct   1380

tttgtgtttc cttcagcagg aatgtactga tgataatttt tctcacaaca gtttttatct   1440

agaatatcat ttttgttaat cttaattctt gaagagaatt tttaatgggt atttaatttt   1500

agggagagat ttttctagcc attgaaaata tcttgttttt ccccagctta ttgaagtata   1560

attaacaaat aaaaattgca tatatttagg cttcacaaca tgatgcttta gtatatgtat   1620

acattgtgaa gagactacca caatcaagct aaacctacat tactgtccct gcattagttt   1680

actgttgaat actagaagtt cttcattcta tctaactgca ttttcatacc cattaagcca   1740

atgtgacaag ctctttgttt cagttggagt gtttgcacaa tttaaatttg ataaattttt   1800

gatagaatta aatttaaatt tatcctccaa ctaaattttt gatagaatta aatttaaatt   1860

tgtcctcca                                                           1869


<210>  1326
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  1326

Met Glu Asn Val Thr Thr Met Asn Glu Phe Leu Leu Leu Gly Leu Thr 
1               5                   10                  15      


Gly Val Gln Glu Leu Gln Pro Phe Phe Phe Gly Ile Phe Leu Ile Ile 
            20                  25                  30          


Tyr Leu Ile Asn Leu Ile Gly Asn Gly Ser Ile Leu Val Met Val Val 
        35                  40                  45              


Leu Glu Pro Gln Leu His Ser Pro Met Tyr Phe Phe Leu Gly Asn Leu 
    50                  55                  60                  


Ser Cys Leu Asp Ile Ser Tyr Ser Ser Val Thr Leu Pro Lys Leu Leu 
65                  70                  75                  80  


Val Asn Leu Val Cys Ser Arg Arg Ala Ile Ser Phe Leu Gly Cys Ile 
                85                  90                  95      


Thr Gln Leu His Phe Phe His Phe Leu Gly Ser Thr Glu Ala Ile Leu 
            100                 105                 110         


Leu Ala Ile Met Ala Phe Asp Arg Phe Val Ala Ile Cys Asn Pro Leu 
        115                 120                 125             


Arg Tyr Thr Val Ile Met Asn Pro Gln Val Cys Ile Leu Leu Ala Ala 
    130                 135                 140                 


Ala Ala Trp Leu Ile Ser Phe Phe Tyr Ala Leu Met His Ser Val Met 
145                 150                 155                 160 


Thr Ala His Leu Ser Phe Cys Gly Ser Gln Lys Leu Asn His Phe Phe 
                165                 170                 175     


Tyr Asp Val Lys Pro Leu Leu Glu Leu Ala Cys Ser Asp Thr Leu Leu 
            180                 185                 190         


Asn Gln Trp Leu Leu Ser Ile Val Thr Gly Ser Ile Ser Met Gly Ala 
        195                 200                 205             


Phe Phe Leu Thr Leu Leu Ser Cys Phe Tyr Val Ile Gly Phe Leu Leu 
    210                 215                 220                 


Phe Lys Asn Arg Ser Cys Arg Ile Leu His Lys Ala Leu Ser Thr Cys 
225                 230                 235                 240 


Ala Ser His Phe Met Val Val Cys Leu Phe Tyr Gly Pro Val Gly Phe 
                245                 250                 255     


Thr Tyr Ile Arg Pro Ala Ser Ala Thr Ser Met Ile Gln Asp Arg Ile 
            260                 265                 270         


Met Ala Ile Met Tyr Ser Ala Val Thr Pro Val Leu Asn Pro Leu Ile 
        275                 280                 285             


Tyr Thr Leu Arg Asn Lys Glu Val Met Met Ala Leu Lys Lys Ile Phe 
    290                 295                 300                 


Gly Arg Lys Leu Phe Lys Asp Trp Gln Gln His His 
305                 310                 315     


<210>  1327
<211>  924
<212>  DNA
<213>  Homosapiens

<400>  1327
atgctgaata caacctcagt caccgaattt ctcctcttgg gagtgacaga cattcaagaa     60

ctgcagcctt ttctcttcgt ggttttcctc accatctact tcatcagtgt gactgggaat    120

ggagccgttc tgatgattgt catctccgat cctagactcc attcccttat gtatttcttc    180

ctgggaaacc tgtcctacct ggatatctgt tactctacgg tgacactgcc aaaaatgctg    240

cagaactttc tctctacaca caaagcaatt tctttcttgg gatgcataag ccagcttcat    300

ttcttccact ccctgggcag cacggagtcc atgttgttcg ccgtgatggc atttgacctc    360

tctgtggcta tctgcaagcc acttcgctac actgtcatca tgaaccctca gctctgtacc    420

cagatggcca tcacaatctg ggtcattggt tttttccatg ccctgctgca ctccgtaatg    480

acttctcgct tgaacttctg tggttccaac cgtatccatc attttctctg tgatattaag    540

ccattgctaa agctggcctg tgggaacact gagcttaatc agtggctact cagtactgtc    600

acggggacaa ttgccatggg ccccttcttt ctgacacttc tctcctattt ctacattatc    660

acttatctct tcttcaagac ccgttcttgt agcatgctct gtaaagcact gtccacttgt    720

gcctcccact tcatggtagt tattcttttc tatgcacctg ttcttttcac ctatatccat    780

cctgcgttag agagcttcat ggaccaggac cggattgttg ccatcatgta cactgtggtc    840

actcctgtac taaacccact gatctatact ttgaggaaca aggaagtgaa gggggccttg    900

ggtagagtga tcagaaggct ttga                                           924


<210>  1328
<211>  307
<212>  PRT
<213>  Homosapiens

<400>  1328

Met Leu Asn Thr Thr Ser Val Thr Glu Phe Leu Leu Leu Gly Val Thr 
1               5                   10                  15      


Asp Ile Gln Glu Leu Gln Pro Phe Leu Phe Val Val Phe Leu Thr Ile 
            20                  25                  30          


Tyr Phe Ile Ser Val Thr Gly Asn Gly Ala Val Leu Met Ile Val Ile 
        35                  40                  45              


Ser Asp Pro Arg Leu His Ser Leu Met Tyr Phe Phe Leu Gly Asn Leu 
    50                  55                  60                  


Ser Tyr Leu Asp Ile Cys Tyr Ser Thr Val Thr Leu Pro Lys Met Leu 
65                  70                  75                  80  


Gln Asn Phe Leu Ser Thr His Lys Ala Ile Ser Phe Leu Gly Cys Ile 
                85                  90                  95      


Ser Gln Leu His Phe Phe His Ser Leu Gly Ser Thr Glu Ser Met Leu 
            100                 105                 110         


Phe Ala Val Met Ala Phe Asp Leu Ser Val Ala Ile Cys Lys Pro Leu 
        115                 120                 125             


Arg Tyr Thr Val Ile Met Asn Pro Gln Leu Cys Thr Gln Met Ala Ile 
    130                 135                 140                 


Thr Ile Trp Val Ile Gly Phe Phe His Ala Leu Leu His Ser Val Met 
145                 150                 155                 160 


Thr Ser Arg Leu Asn Phe Cys Gly Ser Asn Arg Ile His His Phe Leu 
                165                 170                 175     


Cys Asp Ile Lys Pro Leu Leu Lys Leu Ala Cys Gly Asn Thr Glu Leu 
            180                 185                 190         


Asn Gln Trp Leu Leu Ser Thr Val Thr Gly Thr Ile Ala Met Gly Pro 
        195                 200                 205             


Phe Phe Leu Thr Leu Leu Ser Tyr Phe Tyr Ile Ile Thr Tyr Leu Phe 
    210                 215                 220                 


Phe Lys Thr Arg Ser Cys Ser Met Leu Cys Lys Ala Leu Ser Thr Cys 
225                 230                 235                 240 


Ala Ser His Phe Met Val Val Ile Leu Phe Tyr Ala Pro Val Leu Phe 
                245                 250                 255     


Thr Tyr Ile His Pro Ala Leu Glu Ser Phe Met Asp Gln Asp Arg Ile 
            260                 265                 270         


Val Ala Ile Met Tyr Thr Val Val Thr Pro Val Leu Asn Pro Leu Ile 
        275                 280                 285             


Tyr Thr Leu Arg Asn Lys Glu Val Lys Gly Ala Leu Gly Arg Val Ile 
    290                 295                 300                 


Arg Arg Leu 
305         


<210>  1329
<211>  2229
<212>  DNA
<213>  Homosapiens

<400>  1329
ctctaataac gttaggcttg gtatagaaga tgcagagaca tgctaaaatt tctcccccaa     60

ttattgccaa gcagaaactt ggacgatcga catggaaatt gtctccacag gaaacgaaac    120

tattactgaa tttgtcctcc ttggcttcta tgacatccct gaactgcatt tcttgttttt    180

tattgtattc actgctgtct atgtcttcat catcataggg aatatgctga ttattgtagc    240

agtggttagc tcccagaggc tccacaaacc catgtatatt ttcttggcga atctgtcctt    300

cctggatatt ctctacacct ccgcagtgat gccaaaaatg ctggagggct tcctgcaaga    360

agcaactatc tctgtggctg gttgcttgct ccagttcttt atcttcggct ctctagccac    420

agctgaatgc ttactgctgg ctgtcatggc atatgaccgc tacctggcaa tttgctaccc    480

actccactac ccactcctga tggggcccag acggtacatg gggctggtgg tcacaacctg    540

gctctctgga tttgtggtag atggactggt tgtggccctg gtggcccagc tgaggttctg    600

tggccccaac cacattgacc agttttactg tgactttatg cttttcgtgg gcctggcttg    660

ctcggatccc agagtggctc aggtgacaac tctcattctg tctgtgttct gcctcactat    720

tccttttgga ctgattctga catcttatgc cagaattgtg gtggcagtgc tgagagttcc    780

tgctggggca agcaggagaa gggctttctc cacatgctcc tcccacctag ctgtagtgac    840

cacattctat ggaacgctca tgatctttta tgttgcaccc tctgctgtcc attcccagct    900

cctctccaag gtcttctccc tgctctacac tgtggtcacc cctctcttca atcctgtgat    960

ctataccatg aggaacaagg aggtgcatca ggcacttcgg aagattctct gtatcaaaca   1020

aactgaaaca cttgattgaa ggagagtaat gaagatgtta ttttggactt cggacacctc   1080

cattggggac tcttccagga tgggttggag aggagtaact ttgtcttatt cgaccattct   1140

ctttgaactc ttctgcagtt atactaaaaa tgaaaatgat agggcaacaa ttttttaact   1200

tttattttaa gttcaagggt acatgtgcag gtttgttaca taggtaaact tgtgtcatgg   1260

gggtttactg tacagattat ttcatcaccc aggtattaag cctagtactc attaatcatt   1320

tttcctgatc ttctccctcc tcccaacctc caccctcaag taggattcag tgtgttgttc   1380

ccctctatgt atccatatgt tttcataatt tagctcccac ttatgagtga agacatacgg   1440

tatttgattt tctgttcctg tgttagtttg cgaaggatag tagcctccaa ttccatccat   1500

gtcaaataat caaaattatt taaactttga ttagttcttt attaaatatg tcataaatat   1560

ttaaaaataa tacagcaata ccaaaataaa cctagaaata ttgtttttta tattattgtt   1620

gtatgacatt taaaaatttc tttctatgtg tatttatatt tatacataca agttggatca   1680

tggagtttgt aatctggttt tccactgaac actgtgtcac gaacaacttt ttctattaac   1740

aagcatctat ttctttattc ttctgggctt catcgtatgg ctaaacatga tttgttattc   1800

tattttggga atttttagtt gtattctatt cttttactgt acattgttta catctggatt   1860

ttcctgtaat aaacttttag cacctaaatt gcaagatcta aggatatgtg tttttaaaaa   1920

tctaaagctg aattcctttt cttttaaact tcttttcttg tagaacattt caaacataca   1980

taaaagagaa gagcacagtg aacccccatg tactccatgt agccaccatc cagcttcaac   2040

atcaacattt tgctaatctt attttaatta gctacagctc cttgtttgtt agttttcatg   2100

gaaaatttta gggcaaattc cagatgttgt ataactatta tgttgtgtaa gttatgtatg   2160

tacatattcc acatatgtat ttagtataat ctgtgactaa taaagacatt ttaaaaaacc   2220

atgcccaca                                                           2229


<210>  1330
<211>  315
<212>  PRT
<213>  Homosapiens

<400>  1330

Met Glu Ile Val Ser Thr Gly Asn Glu Thr Ile Thr Glu Phe Val Leu 
1               5                   10                  15      


Leu Gly Phe Tyr Asp Ile Pro Glu Leu His Phe Leu Phe Phe Ile Val 
            20                  25                  30          


Phe Thr Ala Val Tyr Val Phe Ile Ile Ile Gly Asn Met Leu Ile Ile 
        35                  40                  45              


Val Ala Val Val Ser Ser Gln Arg Leu His Lys Pro Met Tyr Ile Phe 
    50                  55                  60                  


Leu Ala Asn Leu Ser Phe Leu Asp Ile Leu Tyr Thr Ser Ala Val Met 
65                  70                  75                  80  


Pro Lys Met Leu Glu Gly Phe Leu Gln Glu Ala Thr Ile Ser Val Ala 
                85                  90                  95      


Gly Cys Leu Leu Gln Phe Phe Ile Phe Gly Ser Leu Ala Thr Ala Glu 
            100                 105                 110         


Cys Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys 
        115                 120                 125             


Tyr Pro Leu His Tyr Pro Leu Leu Met Gly Pro Arg Arg Tyr Met Gly 
    130                 135                 140                 


Leu Val Val Thr Thr Trp Leu Ser Gly Phe Val Val Asp Gly Leu Val 
145                 150                 155                 160 


Val Ala Leu Val Ala Gln Leu Arg Phe Cys Gly Pro Asn His Ile Asp 
                165                 170                 175     


Gln Phe Tyr Cys Asp Phe Met Leu Phe Val Gly Leu Ala Cys Ser Asp 
            180                 185                 190         


Pro Arg Val Ala Gln Val Thr Thr Leu Ile Leu Ser Val Phe Cys Leu 
        195                 200                 205             


Thr Ile Pro Phe Gly Leu Ile Leu Thr Ser Tyr Ala Arg Ile Val Val 
    210                 215                 220                 


Ala Val Leu Arg Val Pro Ala Gly Ala Ser Arg Arg Arg Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ser Ser His Leu Ala Val Val Thr Thr Phe Tyr Gly Thr Leu 
                245                 250                 255     


Met Ile Phe Tyr Val Ala Pro Ser Ala Val His Ser Gln Leu Leu Ser 
            260                 265                 270         


Lys Val Phe Ser Leu Leu Tyr Thr Val Val Thr Pro Leu Phe Asn Pro 
        275                 280                 285             


Val Ile Tyr Thr Met Arg Asn Lys Glu Val His Gln Ala Leu Arg Lys 
    290                 295                 300                 


Ile Leu Cys Ile Lys Gln Thr Glu Thr Leu Asp 
305                 310                 315 


<210>  1331
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  1331
atgagtgcaa acacctccat ggtgactgag tttcttcttc tcggcttctc ccacctggcc     60

gacctccagg gcttgctctt ctctgtcttt ctcactatct acctgctgac cgtggcaggc    120

aatttcctca ttgtggtgct ggtctccact gatgctgccc tccagtcccc tatgtacttc    180

ttcctgcgca ccctctcggc cttggagatt ggctatacgt ctgtcacggt ccccctgcta    240

cttcaccacc tccttactgg ccggcgccac atctctcgct ctggatgtgc tctccagatg    300

ttcttcttcc tcttctttgg cgccacggag tgctgcctcc tggcagccat ggcctatgac    360

cgctatgcag ccatctgtga acccctccgc tacccactgc tgctgagcca ccgggtgtgt    420

ctacagctag ctgggtcggc gtgggcctgt ggggtgctgg tggggctggg ccacacccct    480

ttcatcttct ctttgccctt ctgcggcccc aataccatcc cgcagttctt ctgtgagatc    540

cagcctgtcc tgcagctggt atgtggagac acctcgctta atgaactgca gattatcctg    600

gcaacagccc tcctcatcct ctgccccttt ggcctcatcc tgggctccta cgggcgtatc    660

ctcgttacca tcttccggat cccatctgtt gcgggccgcc gcaaggcctt ctccacctgc    720

tcctcccacc tgatcgtggt ctccctcttc tatggcaccg cactctttat ctatattcgc    780

cctaaggcca gctacgatcc ggccactgac cctctggtgt ccctcttcta tgctgtggtc    840

acccccatcc tcaaccccat catctacagc ctgcggaaca cagaggtcaa agctgcccta    900

aagagaacca tccagaaaac ggtgcctatg gagatttga                           939


<210>  1332
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  1332

Met Ser Ala Asn Thr Ser Met Val Thr Glu Phe Leu Leu Leu Gly Phe 
1               5                   10                  15      


Ser His Leu Ala Asp Leu Gln Gly Leu Leu Phe Ser Val Phe Leu Thr 
            20                  25                  30          


Ile Tyr Leu Leu Thr Val Ala Gly Asn Phe Leu Ile Val Val Leu Val 
        35                  40                  45              


Ser Thr Asp Ala Ala Leu Gln Ser Pro Met Tyr Phe Phe Leu Arg Thr 
    50                  55                  60                  


Leu Ser Ala Leu Glu Ile Gly Tyr Thr Ser Val Thr Val Pro Leu Leu 
65                  70                  75                  80  


Leu His His Leu Leu Thr Gly Arg Arg His Ile Ser Arg Ser Gly Cys 
                85                  90                  95      


Ala Leu Gln Met Phe Phe Phe Leu Phe Phe Gly Ala Thr Glu Cys Cys 
            100                 105                 110         


Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Glu Pro 
        115                 120                 125             


Leu Arg Tyr Pro Leu Leu Leu Ser His Arg Val Cys Leu Gln Leu Ala 
    130                 135                 140                 


Gly Ser Ala Trp Ala Cys Gly Val Leu Val Gly Leu Gly His Thr Pro 
145                 150                 155                 160 


Phe Ile Phe Ser Leu Pro Phe Cys Gly Pro Asn Thr Ile Pro Gln Phe 
                165                 170                 175     


Phe Cys Glu Ile Gln Pro Val Leu Gln Leu Val Cys Gly Asp Thr Ser 
            180                 185                 190         


Leu Asn Glu Leu Gln Ile Ile Leu Ala Thr Ala Leu Leu Ile Leu Cys 
        195                 200                 205             


Pro Phe Gly Leu Ile Leu Gly Ser Tyr Gly Arg Ile Leu Val Thr Ile 
    210                 215                 220                 


Phe Arg Ile Pro Ser Val Ala Gly Arg Arg Lys Ala Phe Ser Thr Cys 
225                 230                 235                 240 


Ser Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Leu Phe 
                245                 250                 255     


Ile Tyr Ile Arg Pro Lys Ala Ser Tyr Asp Pro Ala Thr Asp Pro Leu 
            260                 265                 270         


Val Ser Leu Phe Tyr Ala Val Val Thr Pro Ile Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Thr Glu Val Lys Ala Ala Leu Lys Arg Thr Ile 
    290                 295                 300                 


Gln Lys Thr Val Pro Met Glu Ile 
305                 310         


<210>  1333
<211>  3009
<212>  DNA
<213>  Homosapiens

<400>  1333
gtttgctttt agttctcatt gtgagatcac aagtggaggc tccaaccagt ccagaagttc     60

ctttctatgg ggaagctgtg gcagcaaggc cgtgaagaga gtctgactta attgcaaaga    120

cgaggtttca ccatgttgac caggctgatc tcaaacatct gacctcagga agtcagaggc    180

accaatgtga ggttccacct gctttccagc acattcttgg tttcctcact tctgctagac    240

aacgtttgat cagaaggaac agggaacgag aaggagctgc tggatgacga taagcctggg    300

aaagggaggc tgggtgagca gagacagaaa agaaacacct acctgctgtg acctcacaaa    360

cacccaggct gagttttgat aagacaggtt gaatcacact ggggtgacag cctcatccct    420

ccaggtacaa acaagaacag gccatggtta accaaagctc ccccatgggc ttcctccttc    480

tgggcttctc tgaacaccca gcactggaaa ggactctctt tgtggttgtc ttcacttcct    540

acctcttgac cctggtgggc aacacactca tcatcctgct gtctgtactg taccccaggc    600

tccactctcc aatgtacttt ttcctctctg acctctcctt cttggacctc tgctttacca    660

caagttgtgt cccccagatg ctggtcaacc tctggggccc aaagaagacc atcagcttcc    720

tgggatgctc tgtccagctc ttcatcttcc tgtccctggg gaccactgag tgcatcctcc    780

tgacagtgat ggcctttgac cgatacgtgg ctgtctgcca gcccctccac tatgccacca    840

tcatccaccc ccgcctgtgc tggcagctgg catctgtggc ctgggttatg agtctggttc    900

aatcgatagt ccagacacca tccaccctcc acttgccctt ctgtccccac cagcagatag    960

atgacttttt atgtgaggtc ccatctctga ttcgactctc ctgtggagat acctcctaca   1020

atgaaatcca gttggctgtg tccagtgtca tcttcgtggt tgtgcctctc agcctcatcc   1080

ttgcctctta tggagccact gcccaggcag tgctgaggat taactctgcc acagcatgga   1140

gaaaggcctt tgggacctgc tcctcccatc tcactgtggt caccctcttc tacagctcag   1200

tcattgctgt ctacctccag cccaaaaatc cgtatgccca agggaggggc aagttctttg   1260

gtctcttcta tgcagtgggc actccttcac ttaaccctct cgtatacacc ctgaggaaca   1320

aggagataaa gcgagcactc aggaggttac tagggaagga aagagactcc agggaaagct   1380

ggagagctgc ttaatatact ttcgaaagta agaagagttt cttcaagatt tatgaacatg   1440

ttaagttttc cagactacta cccttcccac atacacctga gccactgtgg tgggtcacag   1500

tgtggctatg ttatctatga gagggagaat gagaaagaga gggacagaga gataaaagaa   1560

attgggtgag aggagatagg tagctccata aggcacacaa attcaaatat tatcattcct   1620

atcactgtcc attcttaata tttctatcct ccattctgtt ctttttactg tcatcacttc   1680

tatagatttc ctaactccac catgcctatt tctggttata taattgctct ccaattgtca   1740

tgtcagtgta ggggaactac tccatcatag cattctggac accttgcatg tatctacgta   1800

ggtcatgtaa gcaaaggctt gaagaacagc taatctgaga tttagaagaa tgctttttga   1860

tcctcctgga atatgagagg atgggaggcc ctttagagcc tgcctcaatg ccatctctca   1920

ctctccttct tatatccctg ggagtatgtc atgtgacaag tctttactgt ctcccaggtt   1980

ttggatggag catggggttt tctgccccac accctttagg atatagctga agaatataat   2040

gaggaatagc tggattctag aactgactcc tcaccagtgg tatattccac aacagtgtca   2100

cagtcgtctg gcccctttgg tttccgtgtc atcctttttg gtgtgtagga caaggagcca   2160

gggaattggc acgtttggct tttacttctt ttttatatgt aaataataag ccatctaagt   2220

gtaaaagtgg ctcatatctt ctccagccaa atcagctagg ccatggcctt gccttgcttc   2280

tcatgagtgt gcttgacagt catcaccgtc actctatctt catttctggt tcttaccgtg   2340

ttagcttagt tcattcaagc tactatcaca agctacacat aaattgggtg gtttataaat   2400

aacaaacatt tctttcttac agttctggag gctggaaact ccaagattaa ggcagatttc   2460

atgcctattg agggcctgct ttctgattat agaaggtgac ttcttgctgt gcccacacat   2520

ggtgaaaggg actaccaact ctctggagtc tcttttatga gggcactaat tccaattatg   2580

aagcctcttc cctcatgacc taatcactgc ccaaaggccc catgttctaa tgccatcatc   2640

ttggtggttt aggatttcaa catatgaatt ttggaaggac ataagcattc aaccccctgc   2700

acatgtcttc tttcctactt cctcaaggtt ctttctgtcc agttgctcct tcttctattg   2760

accctttttt gccttctctt tctccttcac tgcctcaagt tacagccaga ggaaaggagg   2820

aactaaaact tagcaaatct ataatcacat gcaaatacac agaatggatt gttacaacca   2880

aaatgcaggc tctattgttt tcaatttagc agcctttcaa atgtatatgg ttctggccac   2940

attaaagttg caaataacac tttttttgag actgaaataa aggtgaaata ttggaaaaaa   3000

aaaaaaaaa                                                           3009


<210>  1334
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  1334

Met Val Asn Gln Ser Ser Pro Met Gly Phe Leu Leu Leu Gly Phe Ser 
1               5                   10                  15      


Glu His Pro Ala Leu Glu Arg Thr Leu Phe Val Val Val Phe Thr Ser 
            20                  25                  30          


Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Val 
        35                  40                  45              


Leu Tyr Pro Arg Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asp Leu 
    50                  55                  60                  


Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu 
65                  70                  75                  80  


Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Gly Cys Ser 
                85                  90                  95      


Val Gln Leu Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu 
            100                 105                 110         


Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 
        115                 120                 125             


His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser 
    130                 135                 140                 


Val Ala Trp Val Met Ser Leu Val Gln Ser Ile Val Gln Thr Pro Ser 
145                 150                 155                 160 


Thr Leu His Leu Pro Phe Cys Pro His Gln Gln Ile Asp Asp Phe Leu 
                165                 170                 175     


Cys Glu Val Pro Ser Leu Ile Arg Leu Ser Cys Gly Asp Thr Ser Tyr 
            180                 185                 190         


Asn Glu Ile Gln Leu Ala Val Ser Ser Val Ile Phe Val Val Val Pro 
        195                 200                 205             


Leu Ser Leu Ile Leu Ala Ser Tyr Gly Ala Thr Ala Gln Ala Val Leu 
    210                 215                 220                 


Arg Ile Asn Ser Ala Thr Ala Trp Arg Lys Ala Phe Gly Thr Cys Ser 
225                 230                 235                 240 


Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val 
                245                 250                 255     


Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Gly Arg Gly Lys Phe Phe 
            260                 265                 270         


Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Val Tyr 
        275                 280                 285             


Thr Leu Arg Asn Lys Glu Ile Lys Arg Ala Leu Arg Arg Leu Leu Gly 
    290                 295                 300                 


Lys Glu Arg Asp Ser Arg Glu Ser Trp Arg Ala Ala 
305                 310                 315     


<210>  1335
<211>  1137
<212>  DNA
<213>  Homosapiens

<400>  1335
atggtctggg ggaaaatttg ctggttcagc cagagggctg gatggacagt gtttgctgag     60

tcacagatat ctctctcatg tagcctttgt ctccacagtg gtgaccagga ggcacagaac    120

ccaaacctgg tatctcagct ctgtggcgtc tttcttcaaa atgagacgaa tgaaaccata    180

catatgcaga tgagcatggc agtgggacag caggccctgc ccttgaatat cattgccccc    240

aaggctgtgc tggtctccct ctgtggggtc ttattgaatg gcactgtctt ctggctgctt    300

tgctgtgggg ccacgaatcc ctacatggta tacatcctcc acctggtcgc tgctgacgtg    360

atctatcttt gctgctcggc agtggggttc ttacaggtga ctctgctaac ttatcatgga    420

gtcgtgtttt ttatccctga tttcctggcc atattgtctc ccttctcctt tgaggtgtgt    480

ctctgtctcc tggtggccat cagcacagag cggtgtgtgt gtgtcctctt ccccatctgg    540

tacagatgcc accgcccaaa atacacatct aatgttgtct gcaccctcat ctggggcctg    600

cctttttgca tcaacatagt aaaatcactt ttcctaactt actggaaaca tgtaaaggca    660

tgtgtcatat ttctaaagct ttctgggctc ttccatgcta tcctttcact tgtgatgtgt    720

gtgtcgagtc tgactctact cattagattc ctgtgctgct cccagcagca aaaggccacc    780

agggtctatg cggtggtgca gatctcggcc cccatgttcc tactctgggc cctacccctg    840

agcgtggcac ccctcataac agatttcaaa atgtttgtca ccacctccta tttaatttcc    900

ttgttcctca ttataaacag cagcgccaac cctatcattt atttctttgt ggggagcctc    960

agaaagaaaa ggctgaagga atctctcaga gtgattctcc aacgggcgtt agcagataag   1020

ccagaggtgg ggaggaacaa aaaggcagct ggcatcgacc caatggagca accacactct   1080

actcagcatg tggagaacct tcttcccagg gagcacaggg tcgatgtgga aacataa      1137


<210>  1336
<211>  378
<212>  PRT
<213>  Homosapiens

<400>  1336

Met Val Trp Gly Lys Ile Cys Trp Phe Ser Gln Arg Ala Gly Trp Thr 
1               5                   10                  15      


Val Phe Ala Glu Ser Gln Ile Ser Leu Ser Cys Ser Leu Cys Leu His 
            20                  25                  30          


Ser Gly Asp Gln Glu Ala Gln Asn Pro Asn Leu Val Ser Gln Leu Cys 
        35                  40                  45              


Gly Val Phe Leu Gln Asn Glu Thr Asn Glu Thr Ile His Met Gln Met 
    50                  55                  60                  


Ser Met Ala Val Gly Gln Gln Ala Leu Pro Leu Asn Ile Ile Ala Pro 
65                  70                  75                  80  


Lys Ala Val Leu Val Ser Leu Cys Gly Val Leu Leu Asn Gly Thr Val 
                85                  90                  95      


Phe Trp Leu Leu Cys Cys Gly Ala Thr Asn Pro Tyr Met Val Tyr Ile 
            100                 105                 110         


Leu His Leu Val Ala Ala Asp Val Ile Tyr Leu Cys Cys Ser Ala Val 
        115                 120                 125             


Gly Phe Leu Gln Val Thr Leu Leu Thr Tyr His Gly Val Val Phe Phe 
    130                 135                 140                 


Ile Pro Asp Phe Leu Ala Ile Leu Ser Pro Phe Ser Phe Glu Val Cys 
145                 150                 155                 160 


Leu Cys Leu Leu Val Ala Ile Ser Thr Glu Arg Cys Val Cys Val Leu 
                165                 170                 175     


Phe Pro Ile Trp Tyr Arg Cys His Arg Pro Lys Tyr Thr Ser Asn Val 
            180                 185                 190         


Val Cys Thr Leu Ile Trp Gly Leu Pro Phe Cys Ile Asn Ile Val Lys 
        195                 200                 205             


Ser Leu Phe Leu Thr Tyr Trp Lys His Val Lys Ala Cys Val Ile Phe 
    210                 215                 220                 


Leu Lys Leu Ser Gly Leu Phe His Ala Ile Leu Ser Leu Val Met Cys 
225                 230                 235                 240 


Val Ser Ser Leu Thr Leu Leu Ile Arg Phe Leu Cys Cys Ser Gln Gln 
                245                 250                 255     


Gln Lys Ala Thr Arg Val Tyr Ala Val Val Gln Ile Ser Ala Pro Met 
            260                 265                 270         


Phe Leu Leu Trp Ala Leu Pro Leu Ser Val Ala Pro Leu Ile Thr Asp 
        275                 280                 285             


Phe Lys Met Phe Val Thr Thr Ser Tyr Leu Ile Ser Leu Phe Leu Ile 
    290                 295                 300                 


Ile Asn Ser Ser Ala Asn Pro Ile Ile Tyr Phe Phe Val Gly Ser Leu 
305                 310                 315                 320 


Arg Lys Lys Arg Leu Lys Glu Ser Leu Arg Val Ile Leu Gln Arg Ala 
                325                 330                 335     


Leu Ala Asp Lys Pro Glu Val Gly Arg Asn Lys Lys Ala Ala Gly Ile 
            340                 345                 350         


Asp Pro Met Glu Gln Pro His Ser Thr Gln His Val Glu Asn Leu Leu 
        355                 360                 365             


Pro Arg Glu His Arg Val Asp Val Glu Thr 
    370                 375             


<210>  1337
<211>  971
<212>  DNA
<213>  Homosapiens

<400>  1337
gattgcttga ggagagaagt atgtgatcag aaagcattct ttgtctatta actcctgccc     60

agcaaaagtg aaagaaaatt catgggagca tgcaagaaca aagagcacag caaagctgga    120

caaacacagc aatccaggca ggggatttcc aactcaactc tggtatgtaa gctgcatgca    180

aagtcctttt tctgtctctg gtttctggcc ccttgtctgc agagatggct cccaatgctt    240

cctgcctctg tgtgcatgtc cgttccgagg aatgggattt aatgaccttt gatgccaacc    300

catatgacag cgtgaaaaaa atcaaagaac atgtccggtc taagaccaag gttcctgtgc    360

aggaccaggt tcttttgctg ggctccaaga tcttaaagcc acggagaagc ctctcatctt    420

acggcattga caaagagaag accatccacc ttaccctgaa agtggtgaag cccagtgatg    480

aggagctgcc cttgtttctt gtggagtcag gtgatgaggc aaagaggcac ctcctccagg    540

tgcgaaggtc cagctcagtg gcacaagtga aagcaatgat cgagactaag acgggtataa    600

tccctgagac ccagattgtg acttgcaatg gaaagagact ggaagatggg aagatgatgg    660

cagattacgg catcagaaag ggcaacttac tcttcctggc atcttattgt attggagggt    720

gaccaccctg ggcatggggt gttggcaggg gtcaaaaagc ttatttcttt taatctctta    780

ctcaacgaac acatcttctg atgatttccc aaaattaatg agaatgagat gagtagagta    840

agatttgggt gggatgggta ggatgaagta tattgcccaa ctctatgttt ctttgattct    900

aacacaatta attaagtgac atgattttta ctaatgtatt actgagacta gtaaataaat    960

ttttaagcca a                                                         971


<210>  1338
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  1338

Met Ala Pro Asn Ala Ser Cys Leu Cys Val His Val Arg Ser Glu Glu 
1               5                   10                  15      


Trp Asp Leu Met Thr Phe Asp Ala Asn Pro Tyr Asp Ser Val Lys Lys 
            20                  25                  30          


Ile Lys Glu His Val Arg Ser Lys Thr Lys Val Pro Val Gln Asp Gln 
        35                  40                  45              


Val Leu Leu Leu Gly Ser Lys Ile Leu Lys Pro Arg Arg Ser Leu Ser 
    50                  55                  60                  


Ser Tyr Gly Ile Asp Lys Glu Lys Thr Ile His Leu Thr Leu Lys Val 
65                  70                  75                  80  


Val Lys Pro Ser Asp Glu Glu Leu Pro Leu Phe Leu Val Glu Ser Gly 
                85                  90                  95      


Asp Glu Ala Lys Arg His Leu Leu Gln Val Arg Arg Ser Ser Ser Val 
            100                 105                 110         


Ala Gln Val Lys Ala Met Ile Glu Thr Lys Thr Gly Ile Ile Pro Glu 
        115                 120                 125             


Thr Gln Ile Val Thr Cys Asn Gly Lys Arg Leu Glu Asp Gly Lys Met 
    130                 135                 140                 


Met Ala Asp Tyr Gly Ile Arg Lys Gly Asn Leu Leu Phe Leu Ala Ser 
145                 150                 155                 160 


Tyr Cys Ile Gly Gly 
                165 


<210>  1339
<211>  1063
<212>  DNA
<213>  Homosapiens

<400>  1339
tgacagcctc atccctccag gtacaaacaa gaacaggcca tggttaacca aagctccaca     60

ccgggcttcc tccttctggg cttctctgaa cacccagggc tggaaaggac tctcttcgtg    120

gttgtcctca cttcctacct cctaacccta gtgggcaaca cactcatcat cctgctgtct    180

gcgctggacc ccaagctcca ctctccaatg tactttttcc tctccaacct ctccttcttg    240

gacctctgtt tcaccacgag ttgtgttccc caaatgctgg tcaacctctg gggcccaaag    300

aagaccatca gcttcctgga ctgctctgtc cagatcttca tcttcctgtc cctggggaca    360

actgagtgca tcctcttgac agtgatggct tttgatcgct acgtggctgt ctgccagccc    420

ctccactatg ccaccatcat ccacccccgc ctgtgctggc agctggcatc tgtggcctgg    480

gtcattgggc tagtggagtc agtggtccag acaccatcca ccctgcacct gcccttctgc    540

cccgatcggc aggtggatga ttttgtctgt gaggtcccag ctctaattcg actctcctgt    600

gaagacacct cctacaatga gatccaggtg gctgttgcca gtgtcttcat cttggttgtg    660

cctctcagcc tcatccttgt ctcttacgga gccattacct gggcagtgct gaggattaac    720

tctgcaaaag ggcggaggaa agcttttggg acctgctcct cccatctcac tgtggtcacc    780

ctcttctaca gctcagtcat tgctgtctac ctccagccca aaaatcccta tgcccaagag    840

aggggcaagt tctttggtct cttctatgca gtgggcactc cttcacttaa ccctctcata    900

tacaccctga ggaacaagga ggtaaccagg gcattcagga gattgctggg gaaggaaatg    960

gggctcacac aaagctgagg gagagctgct taatgtgctt taaaagagag gagattctat   1020

gtgcttttat cagaaagttt gagttccctg cccctctgcc ttc                     1063


<210>  1340
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  1340

Met Val Asn Gln Ser Ser Thr Pro Gly Phe Leu Leu Leu Gly Phe Ser 
1               5                   10                  15      


Glu His Pro Gly Leu Glu Arg Thr Leu Phe Val Val Val Leu Thr Ser 
            20                  25                  30          


Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Ala 
        35                  40                  45              


Leu Asp Pro Lys Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asn Leu 
    50                  55                  60                  


Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu 
65                  70                  75                  80  


Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Asp Cys Ser 
                85                  90                  95      


Val Gln Ile Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu 
            100                 105                 110         


Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 
        115                 120                 125             


His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser 
    130                 135                 140                 


Val Ala Trp Val Ile Gly Leu Val Glu Ser Val Val Gln Thr Pro Ser 
145                 150                 155                 160 


Thr Leu His Leu Pro Phe Cys Pro Asp Arg Gln Val Asp Asp Phe Val 
                165                 170                 175     


Cys Glu Val Pro Ala Leu Ile Arg Leu Ser Cys Glu Asp Thr Ser Tyr 
            180                 185                 190         


Asn Glu Ile Gln Val Ala Val Ala Ser Val Phe Ile Leu Val Val Pro 
        195                 200                 205             


Leu Ser Leu Ile Leu Val Ser Tyr Gly Ala Ile Thr Trp Ala Val Leu 
    210                 215                 220                 


Arg Ile Asn Ser Ala Lys Gly Arg Arg Lys Ala Phe Gly Thr Cys Ser 
225                 230                 235                 240 


Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val 
                245                 250                 255     


Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Glu Arg Gly Lys Phe Phe 
            260                 265                 270         


Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Ile Tyr 
        275                 280                 285             


Thr Leu Arg Asn Lys Glu Val Thr Arg Ala Phe Arg Arg Leu Leu Gly 
    290                 295                 300                 


Lys Glu Met Gly Leu Thr Gln Ser 
305                 310         


<210>  1341
<211>  4445
<212>  DNA
<213>  Homosapiens

<400>  1341
cgctccccgc tcccgtggct gccgccgccc cggggaagaa gagacagggg tggggtttgg     60

gggaagcgag agaggagggg agagaccctg gccaggctgg agcctggatt cgaggggagg    120

agggacggga ggaggagaaa ggtggaggag aagggagggg ggagcgggga ggagcggccg    180

ggcctggggc cttgaggccc ggggagagcc ggggagccgg gcccgcgcgc cgagatgttg    240

ctgctgctgt tactggcgcc actcttcctc cgccccccgg gcgcgggcgg ggcgcagacc    300

cccaacgcca cctcagaagg ttgccagatc atacacccgc cctgggaagg gggcatcagg    360

taccggggcc tgactcggga ccaggtgaag gctatcaact tcctgccagt ggactatgag    420

attgagtatg tgtgccgggg ggagcgcgag gtggtggggc ccaaggtccg caagtgcctg    480

gccaacggct cctggacaga tatggacaca cccagccgct gtgtccgaat ctgctccaag    540

tcttatttga ccctggaaaa tgggaaggtt ttcctgacgg gtggggacct cccagctctg    600

gacggagccc gggtggattt ccggtgtgac cccgacttcc atctggtggg cagctcccgg    660

agcatctgta gtcagggcca gtggagcacc cccaagcccc actgccaggt gaatcgaacg    720

ccacactcag aacggcgcgc agtgtacatc ggggcactgt ttcccatgag cgggggctgg    780

ccagggggcc aggcctgcca gcccgcggtg gagatggcgc tggaggacgt gaatagccgc    840

agggacatcc tgccggacta tgagctcaag ctcatccacc acgacagcaa gtgtgatcca    900

ggccaagcca ccaagtacct atatgagctg ctctacaacg accctatcaa gatcatcctt    960

atgcctggct gcagctctgt ctccacgctg gtggctgagg ctgctaggat gtggaacctc   1020

attgtgcttt cctatggctc cagctcacca gccctgtcaa accggcagcg tttccccact   1080

ttcttccgaa cgcacccatc agccacactc cacaacccta cccgcgtgaa actctttgaa   1140

aagtggggct ggaagaagat tgctaccatc cagcagacca ctgaggtctt cacttcgact   1200

ctggacgacc tggaggaacg agtgaaggag gctggaattg agattacttt ccgccagagt   1260

ttcttctcag atccagctgt gcccgtcaaa aacctgaagc gccaggatgc ccgaatcatc   1320

gtgggacttt tctatgagac tgaagcccgg aaagtttttt gtgaggtgta caaggagcgt   1380

ctctttggga agaagtacgt ctggttcctc attgggtggt atgctgacaa ttggttcaag   1440

atctacgacc cttctatcaa ctgcacagtg gatgagatga ctgaggcggt ggagggccac   1500

atcacaactg agattgtcat gctgaatcct gccaataccc gcagcatttc caacatgaca   1560

tcccaggaat ttgtggagaa actaaccaag cgactgaaaa gacaccctga ggagacagga   1620

ggcttccagg aggcaccgct ggcctatgat gccatctggg ccttggcact ggccctgaac   1680

aagacatctg gaggaggcgg ccgttctggt gtgcgcctgg aggacttcaa ctacaacaac   1740

cagaccatta ccgaccaaat ctaccgggca atgaactctt cgtcctttga gggtgtctct   1800

ggccatgtgg tgtttgatgc cagcggctct cggatggcat ggacgcttat cgagcagctt   1860

cagggtggca gctacaagaa gattggctac tatgacagca ccaaggatga tctttcctgg   1920

tccaaaacag ataaatggat tggagggtcc cccccagctg accagaccct ggtcatcaag   1980

acattccgct tcctgtcaca gaaactcttt atctccgtct cagttctctc cagcctgggc   2040

attgtcctag ctgttgtctg tctgtccttt aacatctaca actcacatgt ccgttatatc   2100

cagaactcac agcccaacct gaacaacctg actgctgtgg gctgctcact ggctttagct   2160

gctgtcttcc ccctggggct cgatggttac cacattggga ggaaccagtt tcctttcgtc   2220

tgccaggccc gcctctggct cctgggcctg ggctttagtc tgggctacgg ttccatgttc   2280

accaagattt ggtgggtcca cacggtcttc acaaagaagg aagaaaagaa ggagtggagg   2340

aagactctgg aaccctggaa gctgtatgcc acagtgggcc tgctggtggg catggatgtc   2400

ctcactctcg ccatctggca gatcgtggac cctctgcacc ggaccattga gacatttgcc   2460

aaggaggaac ctaaggaaga tattgacgtc tctattctgc cccagctgga gcattgcagc   2520

tccaggaaga tgaatacatg gcttggcatt ttctatggtt acaaggggct gctgctgctg   2580

ctgggaatct tccttgctta tgagaccaag agtgtgtcca ctgagaagat caatgatcac   2640

cgggctgtgg gcatggctat ctacaatgtg gcagtcctgt gcctcatcac tgctcctgtc   2700

accatgattc tgtccagcca gcaggatgca gcctttgcct ttgcctctct tgccatagtt   2760

ttctcctcct atatcactct tgttgtgctc tttgtgccca agatgcgcag gctgatcacc   2820

cgaggggaat ggcagtcgga ggcgcaggac accatgaaga cagggtcatc gaccaacaac   2880

aacgaggagg agaagtcccg gctgttggag aaggagaacc gtgaactgga aaagatcatt   2940

gctgagaaag aggagcgtgt ctctgaactg cgccatcaac tccagtctcg gcagcagctc   3000

cgctcccggc gccacccacc gacaccccca gaaccctctg ggggcctgcc caggggaccc   3060

cctgagcccc ccgaccggct tagctgtgat gggagtcgag tgcatttgct ttataagtga   3120

gggtagggtg agggaggaca ggccagtagg gggagggaaa gggagagggg aagggcaggg   3180

gactcaggaa gcagggggtc cccatcccca gctgggaaga acatgctatc caatctcatc   3240

tcttgtaaat acatgtcccc ctgtgagttc tgggctgatt tgggtctctc atacctctgg   3300

gaaacagacc tttttctctc ttactgcttc atgtaatttt gtatcacctc ttcacaattt   3360

agttcgtacc tggcttgaag ctgctcactg ctcacacgct gcctcctcag cagcctcact   3420

gcatctttct cttcccatgc aacaccctct tctagttacc acggcaaccc ctgcagctcc   3480

tctgcctttg tgctctgttc ctgtccagca ggggtctccc aacaagtgct ctttccaccc   3540

caaaggggcc tctccttttc tccactgtca taatctcttt ccatcttact tgcccttcta   3600

tactttctca catgtggctc cccctgaatt ttgcttcctt tgggagctca ttcttttcgc   3660

caaggctcac atgctccttg cctctgctct gtgcactcac gctcagcaca catgcatcct   3720

cccctctcct gcgtgtgccc actgaacatg ctcatgtgta cacacgcttt tcccgtatgc   3780

tttcttcatg ttcagtcaca tgtgctctcg ggtgccctgc attcacagct acgtgtgccc   3840

ctctcatggt catgggtctg cccttgagcg tgtttgggta ggcatgtgca atttgtctag   3900

catgctgagt catgtctttc ctatttgcac acgtccatgt ttatccatgt actttccctg   3960

tgtaccctcc atgtaccttg tgtactttct tcccttaaat catggtattc ttctgacaga   4020

gccatatgta ccctaccctg cacattgtta tgcacttttc cccaattcat gtttggtggg   4080

gccatccaca ccctctcctt gtcacagaat ctccatttct gctcagattc cccccatctc   4140

cattgcattc atgtactacc ctcagtctac actcacaatc atcttctccc aagactgctc   4200

ccttttgttt tgtgtttttt tgaggggaat taaggaaaaa taagtggggg caggtttgga   4260

gagctgcttc cagtggatag ttgatgagaa tcctgaccaa aggaaggcac ccttgactgt   4320

tgggatagac agatggacct atggggtggg aggtggtgtc cctttcacac tgtggtgtct   4380

cttggggaag gatctccccg aatctcaata aaccagtgaa cagtgtgact cggcaaaaaa   4440

aaaaa                                                               4445


<210>  1342
<211>  961
<212>  PRT
<213>  Homosapiens

<400>  1342

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160 


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175     


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190         


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205             


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220                 


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240 


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255     


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270         


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285             


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300                 


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320 


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335     


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350         


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365             


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380                 


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400 


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415     


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430         


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445             


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460                 


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480 


Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495     


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510         


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525             


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540                 


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560 


Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp 
                565                 570                 575     


Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe 
            580                 585                 590         


Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val 
        595                 600                 605             


Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn 
    610                 615                 620                 


Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala 
625                 630                 635                 640 


Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg 
                645                 650                 655     


Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu 
            660                 665                 670         


Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val 
        675                 680                 685             


His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr 
    690                 695                 700                 


Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met 
705                 710                 715                 720 


Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg 
                725                 730                 735     


Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val 
            740                 745                 750         


Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr 
        755                 760                 765             


Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly 
    770                 775                 780                 


Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn 
785                 790                 795                 800 


Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys 
                805                 810                 815     


Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala 
            820                 825                 830         


Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr 
        835                 840                 845             


Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly 
    850                 855                 860                 


Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr 
865                 870                 875                 880 


Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg 
                885                 890                 895     


Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu 
            900                 905                 910         


Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro 
        915                 920                 925             


Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu 
    930                 935                 940                 


Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr 
945                 950                 955                 960 


Lys 
    


<210>  1343
<211>  4039
<212>  DNA
<213>  Homosapiens

<400>  1343
agagccgcgg gggccgtagg aagccaacct tccctgcttc tccggggccc tcgccccctc     60

ctccccacaa aatcagggat ggaggcgcct ccccggcacc ctcttagcag ccctccccag    120

gaaaagtgtc ccccctgagc tcctaacgct ccccaacagc tacccctgcc ccccacgcca    180

tggggcccgg ggcccctttt gcccgggtgg ggtggccact gccgcttctg gttgtgatgg    240

cggcaggggt ggctccggtg tgggcctccc actcccccca tctcccgcgg cctcactcgc    300

gggtcccccc gcacccctcc tcagaacggc gcgcagtgta catcggggca ctgtttccca    360

tgagcggggg ctggccaggg ggccaggcct gccagcccgc ggtggagatg gcgctggagg    420

acgtgaatag ccgcagggac atcctgccgg actatgagct caagctcatc caccacgaca    480

gcaagtgtga tccaggccaa gccaccaagt acctatatga gctgctctac aacgacccta    540

tcaagatcat ccttatgcct ggctgcagct ctgtctccac gctggtggct gaggctgcta    600

ggatgtggaa cctcattgtg ctttcctatg gctccagctc accagccctg tcaaaccggc    660

agcgtttccc cactttcttc cgaacgcacc catcagccac actccacaac cctacccgcg    720

tgaaactctt tgaaaagtgg ggctggaaga agattgctac catccagcag accactgagg    780

tcttcacttc gactctggac gacctggagg aacgagtgaa ggaggctgga attgagatta    840

ctttccgcca gagtttcttc tcagatccag ctgtgcccgt caaaaacctg aagcgccagg    900

atgcccgaat catcgtggga cttttctatg agactgaagc ccggaaagtt ttttgtgagg    960

tgtacaagga gcgtctcttt gggaagaagt acgtctggtt cctcattggg tggtatgctg   1020

acaattggtt caagatctac gacccttcta tcaactgcac agtggatgag atgactgagg   1080

cggtggaggg ccacatcaca actgagattg tcatgctgaa tcctgccaat acccgcagca   1140

tttccaacat gacatcccag gaatttgtgg agaaactaac caagcgactg aaaagacacc   1200

ctgaggagac aggaggcttc caggaggcac cgctggccta tgatgccatc tgggccttgg   1260

cactggccct gaacaagaca tctggaggag gcggccgttc tggtgtgcgc ctggaggact   1320

tcaactacaa caaccagacc attaccgacc aaatctaccg ggcaatgaac tcttcgtcct   1380

ttgagggtgt ctctggccat gtggtgtttg atgccagcgg ctctcggatg gcatggacgc   1440

ttatcgagca gcttcagggt ggcagctaca agaagattgg ctactatgac agcaccaagg   1500

atgatctttc ctggtccaaa acagataaat ggattggagg gtccccccca gctgaccaga   1560

ccctggtcat caagacattc cgcttcctgt cacagaaact ctttatctcc gtctcagttc   1620

tctccagcct gggcattgtc ctagctgttg tctgtctgtc ctttaacatc tacaactcac   1680

atgtccgtta tatccagaac tcacagccca acctgaacaa cctgactgct gtgggctgct   1740

cactggcttt agctgctgtc ttccccctgg ggctcgatgg ttaccacatt gggaggaacc   1800

agtttccttt cgtctgccag gcccgcctct ggctcctggg cctgggcttt agtctgggct   1860

acggttccat gttcaccaag atttggtggg tccacacggt cttcacaaag aaggaagaaa   1920

agaaggagtg gaggaagact ctggaaccct ggaagctgta tgccacagtg ggcctgctgg   1980

tgggcatgga tgtcctcact ctcgccatct ggcagatcgt ggaccctctg caccggacca   2040

ttgagacatt tgccaaggag gaacctaagg aagatattga cgtctctatt ctgccccagc   2100

tggagcattg cagctccagg aagatgaata catggcttgg cattttctat ggttacaagg   2160

ggctgctgct gctgctggga atcttccttg cttatgagac caagagtgtg tccactgaga   2220

agatcaatga tcaccgggct gtgggcatgg ctatctacaa tgtggcagtc ctgtgcctca   2280

tcactgctcc tgtcaccatg attctgtcca gccagcagga tgcagccttt gcctttgcct   2340

ctcttgccat agttttctcc tcctatatca ctcttgttgt gctctttgtg cccaagatgc   2400

gcaggctgat cacccgaggg gaatggcagt cggaggcgca ggacaccatg aagacagggt   2460

catcgaccaa caacaacgag gaggagaagt cccggctgtt ggagaaggag aaccgtgaac   2520

tggaaaagat cattgctgag aaagaggagc gtgtctctga actgcgccat caactccagt   2580

ctcggcagca gctccgctcc cggcgccacc caccgacacc cccagaaccc tctgggggcc   2640

tgcccagggg accccctgag ccccccgacc ggcttagctg tgatgggagt cgagtgcatt   2700

tgctttataa gtgagggtag ggtgagggag gacaggccag tagggggagg gaaagggaga   2760

ggggaagggc aggggactca ggaagcaggg ggtccccatc cccagctggg aagaacatgc   2820

tatccaatct catctcttgt aaatacatgt ccccctgtga gttctgggct gatttgggtc   2880

tctcatacct ctgggaaaca gacctttttc tctcttactg cttcatgtaa ttttgtatca   2940

cctcttcaca atttagttcg tacctggctt gaagctgctc actgctcaca cgctgcctcc   3000

tcagcagcct cactgcatct ttctcttccc atgcaacacc ctcttctagt taccacggca   3060

acccctgcag ctcctctgcc tttgtgctct gttcctgtcc agcaggggtc tcccaacaag   3120

tgctctttcc accccaaagg ggcctctcct tttctccact gtcataatct ctttccatct   3180

tacttgccct tctatacttt ctcacatgtg gctccccctg aattttgctt cctttgggag   3240

ctcattcttt tcgccaaggc tcacatgctc cttgcctctg ctctgtgcac tcacgctcag   3300

cacacatgca tcctcccctc tcctgcgtgt gcccactgaa catgctcatg tgtacacacg   3360

cttttcccgt atgctttctt catgttcagt cacatgtgct ctcgggtgcc ctgcattcac   3420

agctacgtgt gcccctctca tggtcatggg tctgcccttg agcgtgtttg ggtaggcatg   3480

tgcaatttgt ctagcatgct gagtcatgtc tttcctattt gcacacgtcc atgtttatcc   3540

atgtactttc cctgtgtacc ctccatgtac cttgtgtact ttcttccctt aaatcatggt   3600

attcttctga cagagccata tgtaccctac cctgcacatt gttatgcact tttccccaat   3660

tcatgtttgg tggggccatc cacaccctct ccttgtcaca gaatctccat ttctgctcag   3720

attcccccca tctccattgc attcatgtac taccctcagt ctacactcac aatcatcttc   3780

tcccaagact gctccctttt gttttgtgtt tttttgaggg gaattaagga aaaataagtg   3840

ggggcaggtt tggagagctg cttccagtgg atagttgatg agaatcctga ccaaaggaag   3900

gcacccttga ctgttgggat agacagatgg acctatgggg tgggaggtgg tgtccctttc   3960

acactgtggt gtctcttggg gaaggatctc cccgaatctc aataaaccag tgaacagtgt   4020

gactcggcaa aaaaaaaaa                                                4039


<210>  1344
<211>  844
<212>  PRT
<213>  Homosapiens

<400>  1344

Met Gly Pro Gly Ala Pro Phe Ala Arg Val Gly Trp Pro Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Met Ala Ala Gly Val Ala Pro Val Trp Ala Ser His Ser 
            20                  25                  30          


Pro His Leu Pro Arg Pro His Ser Arg Val Pro Pro His Pro Ser Ser 
        35                  40                  45              


Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe Pro Met Ser Gly Gly 
    50                  55                  60                  


Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu Met Ala Leu Glu 
65                  70                  75                  80  


Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr Glu Leu Lys Leu 
                85                  90                  95      


Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala Thr Lys Tyr Leu 
            100                 105                 110         


Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile Leu Met Pro Gly 
        115                 120                 125             


Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala Arg Met Trp Asn 
    130                 135                 140                 


Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala Leu Ser Asn Arg 
145                 150                 155                 160 


Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser Ala Thr Leu His 
                165                 170                 175     


Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly Trp Lys Lys Ile 
            180                 185                 190         


Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser Thr Leu Asp Asp 
        195                 200                 205             


Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile Thr Phe Arg Gln 
    210                 215                 220                 


Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn Leu Lys Arg Gln 
225                 230                 235                 240 


Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr Glu Ala Arg Lys 
                245                 250                 255     


Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly Lys Lys Tyr Val 
            260                 265                 270         


Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe Lys Ile Tyr Asp 
        275                 280                 285             


Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr Glu Ala Val Glu Gly 
    290                 295                 300                 


His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala Asn Thr Arg Ser 
305                 310                 315                 320 


Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys Leu Thr Lys Arg 
                325                 330                 335     


Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln Glu Ala Pro Leu 
            340                 345                 350         


Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu Asn Lys Thr Ser 
        355                 360                 365             


Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp Phe Asn Tyr Asn 
    370                 375                 380                 


Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met Asn Ser Ser Ser 
385                 390                 395                 400 


Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala Ser Gly Ser Arg 
                405                 410                 415     


Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly Ser Tyr Lys Lys 
            420                 425                 430         


Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser Trp Ser Lys Thr 
        435                 440                 445             


Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln Thr Leu Val Ile 
    450                 455                 460                 


Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile Ser Val Ser Val 
465                 470                 475                 480 


Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys Leu Ser Phe Asn 
                485                 490                 495     


Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser Gln Pro Asn Leu 
            500                 505                 510         


Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu Ala Ala Val Phe 
        515                 520                 525             


Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Asn Gln Phe Pro Phe 
    530                 535                 540                 


Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly Phe Ser Leu Gly 
545                 550                 555                 560 


Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His Thr Val Phe Thr 
                565                 570                 575     


Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu Glu Pro Trp Lys 
            580                 585                 590         


Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp Val Leu Thr Leu 
        595                 600                 605             


Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr Ile Glu Thr Phe 
    610                 615                 620                 


Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser Ile Leu Pro Gln 
625                 630                 635                 640 


Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr Trp Leu Gly Ile Phe 
                645                 650                 655     


Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile Phe Leu Ala Tyr 
            660                 665                 670         


Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp His Arg Ala Val 
        675                 680                 685             


Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu Ile Thr Ala Pro 
    690                 695                 700                 


Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala Phe Ala Phe Ala 
705                 710                 715                 720 


Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu Val Val Leu Phe 
                725                 730                 735     


Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu Trp Gln Ser Glu 
            740                 745                 750         


Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn Asn Asn Glu Glu 
        755                 760                 765             


Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu Glu Lys Ile 
    770                 775                 780                 


Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His Gln Leu Gln 
785                 790                 795                 800 


Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro Thr Pro Pro Glu 
                805                 810                 815     


Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu Pro Pro Asp Arg Leu 
            820                 825                 830         


Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
        835                 840                 


<210>  1345
<211>  4260
<212>  DNA
<213>  Homosapiens

<400>  1345
cgctccccgc tcccgtggct gccgccgccc cggggaagaa gagacagggg tggggtttgg     60

gggaagcgag agaggagggg agagaccctg gccaggctgg agcctggatt cgaggggagg    120

agggacggga ggaggagaaa ggtggaggag aagggagggg ggagcgggga ggagcggccg    180

ggcctggggc cttgaggccc ggggagagcc ggggagccgg gcccgcgcgc cgagatgttg    240

ctgctgctgc tactggcgcc actcttcctc cgccccccgg gcgcgggcgg ggcgcatacc    300

cccaacgcca cctcagaagg ttgccagatc atacacccgc cctgggaagg gggcatcagg    360

taccggggcc tgactcggga ccaggtgaag gctatcaact tcctgccagt ggactatgag    420

attgagtatg tgtgccgggg ggagcgcgag gtggtggggc ccaaggtccg caagtgcctg    480

gccaacggct cctggacaga tatggacaca cccagccgct gtgtgaatcg aacgccacac    540

tcagaacggc gcgcagtgta catcggggca ctgtttccca tgagcggggg ctggccaggg    600

ggccaggcct gccagcccgc ggtggagatg gcgctggagg acgtgaatag ccgcagggac    660

atcctgccgg actatgagct caagctcatc caccacgaca gcaagtgtga tccaggccaa    720

gccaccaagt acctatatga gctgctctac aacgacccta tcaagatcat ccttatgcct    780

ggctgcagct ctgtctccac gctggtggct gaggctgcta ggatgtggaa cctcattgtg    840

ctttcctatg gctccagctc accagccctg tcaaaccggc agcgtttccc cactttcttc    900

cgaacgcacc catcagccac actccacaac cctacccgcg tgaaactctt tgaaaagtgg    960

ggctggaaga agattgctac catccagcag accactgagg tcttcacttc gactctggac   1020

gacctggagg aacgagtgaa ggaggctgga attgagatta ctttccgcca gagtttcttc   1080

tcagatccag ctgtgcccgt caaaaacctg aagcgccagg atgcccgaat catcgtggga   1140

cttttctatg agactgaagc ccggaaagtt ttttgtgagg tgtacaagga gcgtctcttt   1200

gggaagaagt acgtctggtt cctcattggg tggtatgctg acaattggtt caagatctac   1260

gacccttcta tcaactgcac agtggatgag atgactgagg cggtggaggg ccacatcaca   1320

actgagattg tcatgctgaa tcctgccaat acccgcagca tttccaacat gacatcccag   1380

gaatttgtgg agaaactaac caagcgactg aaaagacacc ctgaggagac aggaggcttc   1440

caggaggcac cgctggccta tgatgccatc tgggccttgg cactggccct gaacaagaca   1500

tctggaggag gcggccgttc tggtgtgcgc ctggaggact tcaactacaa caaccagacc   1560

attaccgacc aaatctaccg ggcaatgaac tcttcgtcct ttgagggtgt ctctggccat   1620

gtggtgtttg atgccagcgg ctctcggatg gcatggacgc ttatcgagca gcttcagggt   1680

ggcagctaca agaagattgg ctactatgac agcaccaagg atgatctttc ctggtccaaa   1740

acagataaat ggattggagg gtccccccca gctgaccaga ccctggtcat caagacattc   1800

cgcttcctgt cacagaaact ctttatctcc gtctcagttc tctccagcct gggcattgtc   1860

ctagctgttg tctgtctgtc ctttaacatc tacaactcac atgtccgtta tatccagaac   1920

tcacagccca acctgaacaa cctgactgct gtgggctgct cactggcttt agctgctgtc   1980

ttccccctgg ggctcgatgg ttaccacatt gggaggaacc agtttccttt cgtctgccag   2040

gcccgcctct ggctcctggg cctgggcttt agtctgggct acggttccat gttcaccaag   2100

atttggtggg tccacacggt cttcacaaag aaggaagaaa agaaggagtg gaggaagact   2160

ctggaaccct ggaagctgta tgccacagtg ggcctgctgg tgggcatgga tgtcctcact   2220

ctcgccatct ggcagatcgt ggaccctctg caccggacca ttgagacatt tgccaaggag   2280

gaacctaagg aagatattga cgtctctatt ctgccccagc tggagcattg cagctccagg   2340

aagatgaata catggcttgg cattttctat ggttacaagg ggctgctgct gctgctggga   2400

atcttccttg cttatgagac caagagtgtg tccactgaga agatcaatga tcaccgggct   2460

gtgggcatgg ctatctacaa tgtggcagtc ctgtgcctca tcactgctcc tgtcaccatg   2520

attctgtcca gccagcagga tgcagccttt gcctttgcct ctcttgccat agttttctcc   2580

tcctatatca ctcttgttgt gctctttgtg cccaagatgc gcaggctgat cacccgaggg   2640

gaatggcagt cggaggcgca ggacaccatg aagacagggt catcgaccaa caacaacgag   2700

gaggagaagt cccggctgtt ggagaaggag aaccgtgaac tggaaaagat cattgctgag   2760

aaagaggagc gtgtctctga actgcgccat caactccagt ctcggcagca gctccgctcc   2820

cggcgccacc caccgacacc cccagaaccc tctgggggcc tgcccagggg accccctgag   2880

ccccccgacc ggcttagctg tgatgggagt cgagtgcatt tgctttataa gtgagggtag   2940

ggtgagggag gacaggccag tagggggagg gaaagggaga ggggaagggc aggggactca   3000

ggaagcaggg ggtccccatc cccagctggg aagaacatgc tatccaatct catctcttgt   3060

aaatacatgt ccccctgtga gttctgggct gatttgggtc tctcatacct ctgggaaaca   3120

gacctttttc tctcttactg cttcatgtaa ttttgtatca cctcttcaca atttagttcg   3180

tacctggctt gaagctgctc actgctcaca cgctgcctcc tcagcagcct cactgcatct   3240

ttctcttccc atgcaacacc ctcttctagt taccacggca acccctgcag ctcctctgcc   3300

tttgtgctct gttcctgtcc agcaggggtc tcccaacaag tgctctttcc accccaaagg   3360

ggcctctcct tttctccact gtcataatct ctttccatct tacttgccct tctatacttt   3420

ctcacatgtg gctccccctg aattttgctt cctttgggag ctcattcttt tcgccaaggc   3480

tcacatgctc cttgcctctg ctctgtgcac tcacgctcag cacacatgca tcctcccctc   3540

tcctgcgtgt gcccactgaa catgctcatg tgtacacacg cttttcccgt atgctttctt   3600

catgttcagt cacatgtgct ctcgggtgcc ctgcattcac agctacgtgt gcccctctca   3660

tggtcatggg tctgcccttg agcgtgtttg ggtaggcatg tgcaatttgt ctagcatgct   3720

gagtcatgtc tttcctattt gcacacgtcc atgtttatcc atgtactttc cctgtgtacc   3780

ctccatgtac cttgtgtact ttcttccctt aaatcatggt attcttctga cagagccata   3840

tgtaccctac cctgcacatt gttatgcact tttccccaat tcatgtttgg tggggccatc   3900

cacaccctct ccttgtcaca gaatctccat ttctgctcag attcccccca tctccattgc   3960

attcatgtac taccctcagt ctacactcac aatcatcttc tcccaagact gctccctttt   4020

gttttgtgtt tttttgaggg gaattaagga aaaataagtg ggggcaggtt tggagagctg   4080

cttccagtgg atagttgatg agaatcctga ccaaaggaag gcacccttga ctgttgggat   4140

agacagatgg acctatgggg tgggaggtgg tgtccctttc acactgtggt gtctcttggg   4200

gaaggatctc cccgaatctc aataaaccag tgaacagtgt gactcggcaa aaaaaaaaaa   4260


<210>  1346
<211>  899
<212>  PRT
<213>  Homosapiens

<400>  1346

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala His Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Asn Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala 
            100                 105                 110         


Leu Phe Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro 
        115                 120                 125             


Ala Val Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu 
    130                 135                 140                 


Pro Asp Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro 
145                 150                 155                 160 


Gly Gln Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile 
                165                 170                 175     


Lys Ile Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala 
            180                 185                 190         


Glu Ala Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser 
        195                 200                 205             


Ser Pro Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr 
    210                 215                 220                 


His Pro Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu 
225                 230                 235                 240 


Lys Trp Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val 
                245                 250                 255     


Phe Thr Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly 
            260                 265                 270         


Ile Glu Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro 
        275                 280                 285             


Val Lys Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe 
    290                 295                 300                 


Tyr Glu Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg 
305                 310                 315                 320 


Leu Phe Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp 
                325                 330                 335     


Asn Trp Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu 
            340                 345                 350         


Met Thr Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu 
        355                 360                 365             


Asn Pro Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe 
    370                 375                 380                 


Val Glu Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly 
385                 390                 395                 400 


Gly Phe Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala 
                405                 410                 415     


Leu Ala Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg 
            420                 425                 430         


Leu Glu Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr 
        435                 440                 445             


Arg Ala Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val 
    450                 455                 460                 


Phe Asp Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu 
465                 470                 475                 480 


Gln Gly Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp 
                485                 490                 495     


Asp Leu Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro 
            500                 505                 510         


Ala Asp Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys 
        515                 520                 525             


Leu Phe Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala 
    530                 535                 540                 


Val Val Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile 
545                 550                 555                 560 


Gln Asn Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser 
                565                 570                 575     


Leu Ala Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile 
            580                 585                 590         


Gly Arg Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu 
        595                 600                 605             


Gly Leu Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp 
    610                 615                 620                 


Trp Val His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg 
625                 630                 635                 640 


Lys Thr Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val 
                645                 650                 655     


Gly Met Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu 
            660                 665                 670         


His Arg Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile 
        675                 680                 685             


Asp Val Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met 
    690                 695                 700                 


Asn Thr Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Gly Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys 
                725                 730                 735     


Ile Asn Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val 
            740                 745                 750         


Leu Cys Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln 
        755                 760                 765             


Asp Ala Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr 
    770                 775                 780                 


Ile Thr Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr 
785                 790                 795                 800 


Arg Gly Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser 
                805                 810                 815     


Ser Thr Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu 
            820                 825                 830         


Asn Arg Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser 
        835                 840                 845             


Glu Leu Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg 
    850                 855                 860                 


His Pro Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro 
865                 870                 875                 880 


Pro Glu Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu 
                885                 890                 895     


Leu Tyr Lys 
            


<210>  1347
<211>  4294
<212>  DNA
<213>  Homosapiens

<400>  1347
cgctccccgc tcccgtggct gccgccgccc cggggaagaa gagacagggg tggggtttgg     60

gggaagcgag agaggagggg agagaccctg gccaggctgg agcctggatt cgaggggagg    120

agggacggga ggaggagaaa ggtggaggag aagggagggg ggagcgggga ggagcggccg    180

ggcctggggc cttgaggccc ggggagagcc ggggagccgg gcccgcgcgc cgagatgttg    240

ctgctgctgc tactggcgcc actcttcctc cgccccccgg gcgcgggcgg ggcgcagacc    300

cccaacgcca cctcagaagg ttgccagatc atacacccgc cctgggaagg gggcatcagg    360

taccggggcc tgactcggga ccaggtgaag gctatcaact tcctgccagt ggactatgag    420

attgagtatg tgtgccgggg ggagcgcgag gtggtggggc ccaaggtccg caagtgcctg    480

gccaacggct cctggacaga tatggacaca cccagccgct gtgtccgaat ctgctccaag    540

tcttatttga ccctggaaaa tgggaaggtt ttcctgacgg gtggggacct cccagctctg    600

gacggagccc gggtggattt ccggtgtgac cccgacttcc atctggtggg cagctcccgg    660

agcatctgta gtcagggcca gtggagcacc cccaagcccc actgccaggt gaatcgaacg    720

ccacactcag aacggcgcgc agtgtacatc ggggcactgt ttcccatgag cgggggctgg    780

ccagggggcc aggcctgcca gcccgcggtg gagatggcgc tggaggacgt gaatagccgc    840

agggacatcc tgccggacta tgagctcaag ctcatccacc acgacagcaa gtgtgatcca    900

ggccaagcca ccaagtacct atatgagctg ctctacaacg accctatcaa gatcatcctt    960

atgcctggct gcagctctgt ctccacgctg gtggctgagg ctgctaggat gtggaacctc   1020

attgtgcttt cctatggctc cagctcacca gccctgtcaa accggcagcg tttccccact   1080

ttcttccgaa cgcacccatc agccacactc cacaacccta cccgcgtgaa actctttgaa   1140

aagtggggct ggaagaagat tgctaccatc cagcagacca ctgaggtctt cacttcgact   1200

ctggacgacc tggaggaacg agtgaaggag gctggaattg agattacttt ccgccagagt   1260

ttcttctcag atccagctgt gcccgtcaaa aacctgaagc gccaggatgc ccgaatcatc   1320

gtgggacttt tctatgagac tgaagcccgg aaagtttttt gtgaggtgta caaggagcgt   1380

ctctttggga agaagtacgt ctggttcctc attgggtggt atgctgacaa ttggttcaag   1440

atctacgacc cttctatcaa ctgcacagtg gatgagatga ctgaggcggt ggagggccac   1500

atcacaactg agatcgtcat gctgaatcct gccaataccc gcagcatttc caacatgaca   1560

tcccaggaat ttgtggagaa actaaccaag cgactgaaaa gacaccctga ggagacagga   1620

ggcttccagg aggcaccgct ggcctatgat gccatctggg ccttggcact ggccctgaac   1680

aagacatctg gaggaggcag ccgttccggc gtgcgcctgg aggacttcaa ctacaacaac   1740

cagaccatta ccgaccaaat ctaccgggca atgaactcct cgtcctttga gggtgtctct   1800

ggccatgtgg tgtttgatgc cagcggctct cggatggcat ggacgcttat cgagcagctt   1860

cagggtggca gctacaagaa gattggctac tatgacagca ccaaggatga tctttcctgg   1920

tccaaaacag ataaatggat tgttatatcc agaactcaca gcccaacctg acaacctgac   1980

tgctgtgggc tgctcactgg ctttagctgc tgtcttcccc ctggggctcg atggttacca   2040

cattgggagg aaccagtttc ctttcgtctg ccaggcccgc ctctggctcc tgggcctggg   2100

ctttagtctg ggctacggtt ccatgttcac caagatttgg tgggtccaca cggtcttcac   2160

aaagaaggaa gaaaagaagg agtggaggaa gactctggaa ccctggaagc tgtatgccac   2220

agtgggcctg ctggtgggca tggatgtcct cactctcgcc atctggcaga tcgtggaccc   2280

tctgcaccgg accattgaga catttgccaa ggaggaacct aaggaagata ttgacgtctc   2340

tattctgccc cagctggagc attgcagctc caggaagatg aatacatggc ttggcatttt   2400

ctatggttac aaggggctgc tgctgctgct gggaatcttc cttgcttatg agaccaagag   2460

tgtgtccact gagaagatca atgatcaccg ggctgtgggc atggctatct acaatgtggc   2520

agtcctgtgc ctcatcactg ctcctgtcac catgattctg tccagccagc aggatgcagc   2580

ctttgccttt gcctctcttg ccatagtttt ctcctcctat atcactcttg ttgtgctctt   2640

tgtgcccaag atgcgcaggc tgatcacccg aggggaatgg cagtcggagg cgcaggacac   2700

catgaagaca gggtcatcga ccaacaacaa cgaggaggag aagtcccggc tgttggagaa   2760

ggagaaccgt gaactggaaa agatcattgc tgagaaagag gagcgtgtct ctgaactgcg   2820

ccatcaactc cagtctcggc agcagctccg ctcccggcgc cacccaccga cacccccaga   2880

accctctggg ggcctgccca ggggaccccc tgagcccccc gaccggctta gctgtgatgg   2940

gagtcgagtg catttgcttt ataagtgagg gtagggtgag ggaggacagg ccagtagggg   3000

gagggaaagg gagaggggaa gggcagggga ctcaggaagc agggggtccc catccccagc   3060

tgggaagaac atgctatcca atctcatctc ttgtaaatac atgtccccct gtgagttctg   3120

ggctgatttg ggtctctcat acctctggga aacagacctt tttctctctt actgcttcat   3180

gtaattttgt atcacctctt cacaatttag ttcgtacctg gcttgaagct gctcactgct   3240

cacacgctgc ctcctcagca gcctcactgc atctttctct tcccatgcaa caccctcttc   3300

tagttaccac ggcaacccct gcagctcctc tgcctttgtg ctctgttcct gtccagcagg   3360

ggtctcccaa caagtgctct ttccacccca aaggggcctc tccttttctc cactgtcata   3420

atctctttcc atcttacttg cccttctata ctttctcaca tgtggctccc cctgaatttt   3480

gcttcctttg ggagctcatt cttttcgcca aggctcacat gctccttgcc tctgctctgt   3540

gcactcacgc tcagcacaca tgcatcctcc cctctcctgc gtgtgcccac tgaacatgct   3600

catgtgtaca cacgcttttc ccgtatgctt tcttcatgtt cagtcacatg tgctctcggg   3660

tgccctgcat tcacagctac gtgtgcccct ctcatggtca tgggtctgcc cttgagcgtg   3720

tttgggtagg catgtgcaat ttgtctagca tgctgagtca tgtctttcct atttgcacac   3780

gtccatgttt atccatgtac tttccctgtg taccctccat gtaccttgtg tactttcttc   3840

ccttaaatca tggtattctt ctgacagagc catatgtacc ctaccctgca cattgttatg   3900

cacttttccc caattcatgt ttggtggggc catccacacc ctctccttgt cacagaatct   3960

ccatttctgc tcagattccc cccatctcca ttgcattcat gtactaccct cagtctacac   4020

tcacaatcat cttctcccaa gactgctccc ttttgttttg tgtttttttg aggggaatta   4080

aggaaaaata agtgggggca ggtttggaga gctgcttcca gtggatagtt gatgagaatc   4140

ctgaccaaag gaaggcaccc ttgactgttg ggatagacag atggacctat ggggtgggag   4200

gtggtgtccc tttcacactg tggtgtctct tggggaagga tctccccgaa tctcaataaa   4260

ccagtgaaca gtgtgactcg gcaaaaaaaa aaaa                               4294


<210>  1348
<211>  578
<212>  PRT
<213>  Homosapiens

<400>  1348

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160 


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175     


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190         


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205             


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220                 


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240 


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255     


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270         


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285             


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300                 


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320 


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335     


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350         


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365             


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380                 


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400 


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415     


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430         


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445             


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460                 


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480 


Leu Asn Lys Thr Ser Gly Gly Gly Ser Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495     


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510         


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525             


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540                 


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560 


Ser Trp Ser Lys Thr Asp Lys Trp Ile Val Ile Ser Arg Thr His Ser 
                565                 570                 575     


Pro Thr 
        


<210>  1349
<211>  2050
<212>  DNA
<213>  Homosapiens

<400>  1349
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg agtcctttgg    780

tgttctagga ccccaggtta aggaaccaaa aaagacaggg caattccttg aagagctacg    840

aaatcccttc tgagtgatgt cacatcttgg caggggtgga ggagagcctg gttgcccagg    900

gatttgtcct tggggacatc tcatccatca agttgcacac tcactggcat ctttgctatg    960

gggacattcc aatttgcact ttcaggaaca ctctgaattc caagtagaat tgatttccct   1020

tcttctgtca tctacctttt ctcttcattt tcccattttt attacccttc tttccatttc   1080

tctctccagt cttccacctg gaagccctct ctggctaagg acaggcaggt gcccctctct   1140

ccatcagagg acacctgtac tggagagcaa cacaggatgg tctctgccat gaactggagg   1200

ccaggaatct cctcactgaa aattacagta tggtaacttt gcaaatggtg gttgtttctt   1260

ccaagactcc agccctgatt gcgcaaaact gaaaggcatg tgaagggaag gaagaggaag   1320

agtgcaaaac attgaagaga gagctgagtg agctgaagag tgaggatatg agtagcccca   1380

acccaaacct ggagatgggg agaaacctac agaatactag ccagagctcc tccttgtctt   1440

ggcagcctac tagggacctg gggaagcaaa aacgaaagct gggcaacatg cctgctttag   1500

aatgttttcc ttctacttac acatcttcca caggtctcag aatctttcct tcctctcatc   1560

cttttctcct atcttcatat ctatcagagt atccactgtt tattcaacaa ctactacttg   1620

atggtcagac acaaacaaac aagctaggtg ctaattaata aagatacgag ttttggccgg   1680

gtgcggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cgaatcacga   1740

ggtcaggagt tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac   1800

aaacaattaa ctgagcatag tggtgggcac ctataatacc agctactccg gaggctgagg   1860

caggagaatc gcttgaaccc aggaggcaga ggttgcagtg agctgagatc gtgccactgc   1920

actctagccg gagtgacaga gtaagactct gtctcaaaaa taaataaata aataaataaa   1980

taaataaata aataaataaa taaaaaataa taatacaagt tttcataagc acacttctaa   2040

aaaaaaaaaa                                                          2050


<210>  1350
<211>  224
<212>  PRT
<213>  Homosapiens

<400>  1350

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205             


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
    210                 215                 220                 


<210>  1351
<211>  1731
<212>  DNA
<213>  Homosapiens

<400>  1351
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg tcttccacct    780

ggaagccctc tctggctaag gacaggcagg tgcccctctc tccatcagag gacacctgta    840

ctggagagca acacaggatg gtctctgcca tgaactggag gccaggaatc tcctcactga    900

aaattacagt atggtaactt tgcaaatggt ggttgtttct tccaagactc cagccctgat    960

tgcgcaaaac tgaaaggcat gtgaagggaa ggaagaggaa gagtgcaaaa cattgaagag   1020

agagctgagt gagctgaaga gtgaggatat gagtagcccc aacccaaacc tggagatggg   1080

gagaaaccta cagaatacta gccagagctc ctccttgtct tggcagccta ctagggacct   1140

ggggaagcaa aaacgaaagc tgggcaacat gcctgcttta gaatgttttc cttctactta   1200

cacatcttcc acaggtctca gaatctttcc ttcctctcat ccttttctcc tatcttcata   1260

tctatcagag tatccactgt ttattcaaca actactactt gatggtcaga cacaaacaaa   1320

caagctaggt gctaattaat aaagatacga gttttggccg ggtgcggtgg ctcacgcctg   1380

taatcccagc actttgggag gccgaggcgg gcgaatcacg aggtcaggag ttcaagacca   1440

gcctggccaa catggtgaaa ccccatctct actaaaaata caaacaatta actgagcata   1500

gtggtgggca cctataatac cagctactcc ggaggctgag gcaggagaat cgcttgaacc   1560

caggaggcag aggttgcagt gagctgagat cgtgccactg cactctagcc ggagtgacag   1620

agtaagactc tgtctcaaaa ataaataaat aaataaataa ataaataaat aaataaataa   1680

ataaaaaata ataatacaag ttttcataag cacacttcta aaaaaaaaaa a            1731


<210>  1352
<211>  206
<212>  PRT
<213>  Homosapiens

<400>  1352

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Val Phe His Leu Glu Ala Leu Ser Gly 
        195                 200                 205     


<210>  1353
<211>  1869
<212>  DNA
<213>  Homosapiens

<400>  1353
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg atccccactt    780

tctgagggtg ccctgctgga agataaccct gtttgtaatt gtgccggttc ttggaccctt    840

ggttgccttg atcatctgct acaactggct acatcgaaga ctagcagggc aattccttga    900

agagctactc ttccacctgg aagccctctc tggctaagga caggcaggtg cccctctctc    960

catcagagga cacctgtact ggagagcaac acaggatggt ctctgccatg aactggaggc   1020

caggaatctc ctcactgaaa attacagtat ggtaactttg caaatggtgg ttgtttcttc   1080

caagactcca gccctgattg cgcaaaactg aaaggcatgt gaagggaagg aagaggaaga   1140

gtgcaaaaca ttgaagagag agctgagtga gctgaagagt gaggatatga gtagccccaa   1200

cccaaacctg gagatgggga gaaacctaca gaatactagc cagagctcct ccttgtcttg   1260

gcagcctact agggacctgg ggaagcaaaa acgaaagctg ggcaacatgc ctgctttaga   1320

atgttttcct tctacttaca catcttccac aggtctcaga atctttcctt cctctcatcc   1380

ttttctccta tcttcatatc tatcagagta tccactgttt attcaacaac tactacttga   1440

tggtcagaca caaacaaaca agctaggtgc taattaataa agatacgagt tttggccggg   1500

tgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc gaatcacgag   1560

gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccatctctac taaaaataca   1620

aacaattaac tgagcatagt ggtgggcacc tataatacca gctactccgg aggctgaggc   1680

aggagaatcg cttgaaccca ggaggcagag gttgcagtga gctgagatcg tgccactgca   1740

ctctagccgg agtgacagag taagactctg tctcaaaaat aaataaataa ataaataaat   1800

aaataaataa ataaataaat aaaaaataat aatacaagtt ttcataagca cacttctaaa   1860

aaaaaaaaa                                                           1869


<210>  1354
<211>  252
<212>  PRT
<213>  Homosapiens

<400>  1354

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Leu Phe His Leu Glu Ala Leu Ser Gly 
                245                 250         


<210>  1355
<211>  2119
<212>  DNA
<213>  Homosapiens

<400>  1355
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg atccccactt    780

tctgagggtg ccctgctgga agataaccct gtttgtaatt gtgccggttc ttggaccctt    840

ggttgccttg atcatctgct acaactggct acatcgaaga ctagcagggc aattccttga    900

agagctacga aatcccttct gagtgatgtc acatcttggc aggggtggag gagagcctgg    960

ttgcccaggg atttgtcctt ggggacatct catccatcaa gttgcacact cactggcatc   1020

tttgctatgg ggacattcca atttgcactt tcaggaacac tctgaattcc aagtagaatt   1080

gatttccctt cttctgtcat ctaccttttc tcttcatttt cccattttta ttacccttct   1140

ttccatttct ctctccagtc ttccacctgg aagccctctc tggctaagga caggcaggtg   1200

cccctctctc catcagagga cacctgtact ggagagcaac acaggatggt ctctgccatg   1260

aactggaggc caggaatctc ctcactgaaa attacagtat ggtaactttg caaatggtgg   1320

ttgtttcttc caagactcca gccctgattg cgcaaaactg aaaggcatgt gaagggaagg   1380

aagaggaaga gtgcaaaaca ttgaagagag agctgagtga gctgaagagt gaggatatga   1440

gtagccccaa cccaaacctg gagatgggga gaaacctaca gaatactagc cagagctcct   1500

ccttgtcttg gcagcctact agggacctgg ggaagcaaaa acgaaagctg ggcaacatgc   1560

ctgctttaga atgttttcct tctacttaca catcttccac aggtctcaga atctttcctt   1620

cctctcatcc ttttctccta tcttcatatc tatcagagta tccactgttt attcaacaac   1680

tactacttga tggtcagaca caaacaaaca agctaggtgc taattaataa agatacgagt   1740

tttggccggg tgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc   1800

gaatcacgag gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccatctctac   1860

taaaaataca aacaattaac tgagcatagt ggtgggcacc tataatacca gctactccgg   1920

aggctgaggc aggagaatcg cttgaaccca ggaggcagag gttgcagtga gctgagatcg   1980

tgccactgca ctctagccgg agtgacagag taagactctg tctcaaaaat aaataaataa   2040

ataaataaat aaataaataa ataaataaat aaaaaataat aatacaagtt ttcataagca   2100

cacttctaaa aaaaaaaaa                                                2119


<210>  1356
<211>  247
<212>  PRT
<213>  Homosapiens

<400>  1356

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Asn Pro Phe 
                245         


<210>  1357
<211>  1752
<212>  DNA
<213>  Homosapiens

<400>  1357
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg ggcaattcct    780

tgaagagcta ctcttccacc tggaagccct ctctggctaa ggacaggcag gtgcccctct    840

ctccatcaga ggacacctgt actggagagc aacacaggat ggtctctgcc atgaactgga    900

ggccaggaat ctcctcactg aaaattacag tatggtaact ttgcaaatgg tggttgtttc    960

ttccaagact ccagccctga ttgcgcaaaa ctgaaaggca tgtgaaggga aggaagagga   1020

agagtgcaaa acattgaaga gagagctgag tgagctgaag agtgaggata tgagtagccc   1080

caacccaaac ctggagatgg ggagaaacct acagaatact agccagagct cctccttgtc   1140

ttggcagcct actagggacc tggggaagca aaaacgaaag ctgggcaaca tgcctgcttt   1200

agaatgtttt ccttctactt acacatcttc cacaggtctc agaatctttc cttcctctca   1260

tccttttctc ctatcttcat atctatcaga gtatccactg tttattcaac aactactact   1320

tgatggtcag acacaaacaa acaagctagg tgctaattaa taaagatacg agttttggcc   1380

gggtgcggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg ggcgaatcac   1440

gaggtcagga gttcaagacc agcctggcca acatggtgaa accccatctc tactaaaaat   1500

acaaacaatt aactgagcat agtggtgggc acctataata ccagctactc cggaggctga   1560

ggcaggagaa tcgcttgaac ccaggaggca gaggttgcag tgagctgaga tcgtgccact   1620

gcactctagc cggagtgaca gagtaagact ctgtctcaaa aataaataaa taaataaata   1680

aataaataaa taaataaata aataaaaaat aataatacaa gttttcataa gcacacttct   1740

aaaaaaaaaa aa                                                       1752


<210>  1358
<211>  213
<212>  PRT
<213>  Homosapiens

<400>  1358

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 
        195                 200                 205             


Glu Ala Leu Ser Gly 
    210             


<210>  1359
<211>  1800
<212>  DNA
<213>  Homosapiens

<400>  1359
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg agtcctttgg    780

tgttctagga ccccaggtta aggaaccaaa aaagacaggg caattccttg aagagctact    840

cttccacctg gaagccctct ctggctaagg acaggcaggt gcccctctct ccatcagagg    900

acacctgtac tggagagcaa cacaggatgg tctctgccat gaactggagg ccaggaatct    960

cctcactgaa aattacagta tggtaacttt gcaaatggtg gttgtttctt ccaagactcc   1020

agccctgatt gcgcaaaact gaaaggcatg tgaagggaag gaagaggaag agtgcaaaac   1080

attgaagaga gagctgagtg agctgaagag tgaggatatg agtagcccca acccaaacct   1140

ggagatgggg agaaacctac agaatactag ccagagctcc tccttgtctt ggcagcctac   1200

tagggacctg gggaagcaaa aacgaaagct gggcaacatg cctgctttag aatgttttcc   1260

ttctacttac acatcttcca caggtctcag aatctttcct tcctctcatc cttttctcct   1320

atcttcatat ctatcagagt atccactgtt tattcaacaa ctactacttg atggtcagac   1380

acaaacaaac aagctaggtg ctaattaata aagatacgag ttttggccgg gtgcggtggc   1440

tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cgaatcacga ggtcaggagt   1500

tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaacaattaa   1560

ctgagcatag tggtgggcac ctataatacc agctactccg gaggctgagg caggagaatc   1620

gcttgaaccc aggaggcaga ggttgcagtg agctgagatc gtgccactgc actctagccg   1680

gagtgacaga gtaagactct gtctcaaaaa taaataaata aataaataaa taaataaata   1740

aataaataaa taaaaaataa taatacaagt tttcataagc acacttctaa aaaaaaaaaa   1800


<210>  1360
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  1360

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205             


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 
    210                 215                 220                 


Glu Ala Leu Ser Gly 
225                 


<210>  1361
<211>  2002
<212>  DNA
<213>  Homosapiens

<400>  1361
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg ggcaattcct    780

tgaagagcta cgaaatccct tctgagtgat gtcacatctt ggcaggggtg gaggagagcc    840

tggttgccca gggatttgtc cttggggaca tctcatccat caagttgcac actcactggc    900

atctttgcta tggggacatt ccaatttgca ctttcaggaa cactctgaat tccaagtaga    960

attgatttcc cttcttctgt catctacctt ttctcttcat tttcccattt ttattaccct   1020

tctttccatt tctctctcca gtcttccacc tggaagccct ctctggctaa ggacaggcag   1080

gtgcccctct ctccatcaga ggacacctgt actggagagc aacacaggat ggtctctgcc   1140

atgaactgga ggccaggaat ctcctcactg aaaattacag tatggtaact ttgcaaatgg   1200

tggttgtttc ttccaagact ccagccctga ttgcgcaaaa ctgaaaggca tgtgaaggga   1260

aggaagagga agagtgcaaa acattgaaga gagagctgag tgagctgaag agtgaggata   1320

tgagtagccc caacccaaac ctggagatgg ggagaaacct acagaatact agccagagct   1380

cctccttgtc ttggcagcct actagggacc tggggaagca aaaacgaaag ctgggcaaca   1440

tgcctgcttt agaatgtttt ccttctactt acacatcttc cacaggtctc agaatctttc   1500

cttcctctca tccttttctc ctatcttcat atctatcaga gtatccactg tttattcaac   1560

aactactact tgatggtcag acacaaacaa acaagctagg tgctaattaa taaagatacg   1620

agttttggcc gggtgcggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg   1680

ggcgaatcac gaggtcagga gttcaagacc agcctggcca acatggtgaa accccatctc   1740

tactaaaaat acaaacaatt aactgagcat agtggtgggc acctataata ccagctactc   1800

cggaggctga ggcaggagaa tcgcttgaac ccaggaggca gaggttgcag tgagctgaga   1860

tcgtgccact gcactctagc cggagtgaca gagtaagact ctgtctcaaa aataaataaa   1920

taaataaata aataaataaa taaataaata aataaaaaat aataatacaa gttttcataa   1980

gcacacttct aaaaaaaaaa aa                                            2002


<210>  1362
<211>  208
<212>  PRT
<213>  Homosapiens

<400>  1362

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
        195                 200                 205             


<210>  1363
<211>  2007
<212>  DNA
<213>  Homosapiens

<400>  1363
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagtgtctc actctgtgac ccaggattgg ttgcagtggc acgatcatgg    660

ctcattgcag cctccacctc ccaggctcaa gtgatcctcc tgactcagcc tcttgaatag    720

ctgagaccac aggcttgtgt caccatgccc agatcctttc tactgggtga gccctggagt    780

gctggttctc ctcgcggtgc tgcctgtgct cctcctgcag atcactgttg gcctcatctt    840

cctctgcctg cagtacagac tgagaggaaa acttcgagca gagatagaga atctccaccg    900

gacttttgat ccccactttc tgagggtgcc ctgctggaag ataaccctgt ttgtaattgt    960

gccggttctt ggacccttgg ttgccttgat catctgctac aactggctac atcgaagact   1020

agcagggcaa ttccttgaag agctactctt ccacctggaa gccctctctg gctaaggaca   1080

ggcaggtgcc cctctctcca tcagaggaca cctgtactgg agagcaacac aggatggtct   1140

ctgccatgaa ctggaggcca ggaatctcct cactgaaaat tacagtatgg taactttgca   1200

aatggtggtt gtttcttcca agactccagc cctgattgcg caaaactgaa aggcatgtga   1260

agggaaggaa gaggaagagt gcaaaacatt gaagagagag ctgagtgagc tgaagagtga   1320

ggatatgagt agccccaacc caaacctgga gatggggaga aacctacaga atactagcca   1380

gagctcctcc ttgtcttggc agcctactag ggacctgggg aagcaaaaac gaaagctggg   1440

caacatgcct gctttagaat gttttccttc tacttacaca tcttccacag gtctcagaat   1500

ctttccttcc tctcatcctt ttctcctatc ttcatatcta tcagagtatc cactgtttat   1560

tcaacaacta ctacttgatg gtcagacaca aacaaacaag ctaggtgcta attaataaag   1620

atacgagttt tggccgggtg cggtggctca cgcctgtaat cccagcactt tgggaggccg   1680

aggcgggcga atcacgaggt caggagttca agaccagcct ggccaacatg gtgaaacccc   1740

atctctacta aaaatacaaa caattaactg agcatagtgg tgggcaccta taataccagc   1800

tactccggag gctgaggcag gagaatcgct tgaacccagg aggcagaggt tgcagtgagc   1860

tgagatcgtg ccactgcact ctagccggag tgacagagta agactctgtc tcaaaaataa   1920

ataaataaat aaataaataa ataaataaat aaataaataa aaaataataa tacaagtttt   1980

cataagcaca cttctaaaaa aaaaaaa                                       2007


<210>  1364
<211>  171
<212>  PRT
<213>  Homosapiens

<400>  1364

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Val Ser His Ser Val Thr Gln Asp Trp Leu Gln Trp His Asp His 
145                 150                 155                 160 


Gly Ser Leu Gln Pro Pro Pro Pro Arg Leu Lys 
                165                 170     


<210>  1365
<211>  2257
<212>  DNA
<213>  Homosapiens

<400>  1365
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagtgtctc actctgtgac ccaggattgg ttgcagtggc acgatcatgg    660

ctcattgcag cctccacctc ccaggctcaa gtgatcctcc tgactcagcc tcttgaatag    720

ctgagaccac aggcttgtgt caccatgccc agatcctttc tactgggtga gccctggagt    780

gctggttctc ctcgcggtgc tgcctgtgct cctcctgcag atcactgttg gcctcatctt    840

cctctgcctg cagtacagac tgagaggaaa acttcgagca gagatagaga atctccaccg    900

gacttttgat ccccactttc tgagggtgcc ctgctggaag ataaccctgt ttgtaattgt    960

gccggttctt ggacccttgg ttgccttgat catctgctac aactggctac atcgaagact   1020

agcagggcaa ttccttgaag agctacgaaa tcccttctga gtgatgtcac atcttggcag   1080

gggtggagga gagcctggtt gcccagggat ttgtccttgg ggacatctca tccatcaagt   1140

tgcacactca ctggcatctt tgctatgggg acattccaat ttgcactttc aggaacactc   1200

tgaattccaa gtagaattga tttcccttct tctgtcatct accttttctc ttcattttcc   1260

catttttatt acccttcttt ccatttctct ctccagtctt ccacctggaa gccctctctg   1320

gctaaggaca ggcaggtgcc cctctctcca tcagaggaca cctgtactgg agagcaacac   1380

aggatggtct ctgccatgaa ctggaggcca ggaatctcct cactgaaaat tacagtatgg   1440

taactttgca aatggtggtt gtttcttcca agactccagc cctgattgcg caaaactgaa   1500

aggcatgtga agggaaggaa gaggaagagt gcaaaacatt gaagagagag ctgagtgagc   1560

tgaagagtga ggatatgagt agccccaacc caaacctgga gatggggaga aacctacaga   1620

atactagcca gagctcctcc ttgtcttggc agcctactag ggacctgggg aagcaaaaac   1680

gaaagctggg caacatgcct gctttagaat gttttccttc tacttacaca tcttccacag   1740

gtctcagaat ctttccttcc tctcatcctt ttctcctatc ttcatatcta tcagagtatc   1800

cactgtttat tcaacaacta ctacttgatg gtcagacaca aacaaacaag ctaggtgcta   1860

attaataaag atacgagttt tggccgggtg cggtggctca cgcctgtaat cccagcactt   1920

tgggaggccg aggcgggcga atcacgaggt caggagttca agaccagcct ggccaacatg   1980

gtgaaacccc atctctacta aaaatacaaa caattaactg agcatagtgg tgggcaccta   2040

taataccagc tactccggag gctgaggcag gagaatcgct tgaacccagg aggcagaggt   2100

tgcagtgagc tgagatcgtg ccactgcact ctagccggag tgacagagta agactctgtc   2160

tcaaaaataa ataaataaat aaataaataa ataaataaat aaataaataa aaaataataa   2220

tacaagtttt cataagcaca cttctaaaaa aaaaaaa                            2257


<210>  1366
<211>  171
<212>  PRT
<213>  Homosapiens

<400>  1366

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Val Ser His Ser Val Thr Gln Asp Trp Leu Gln Trp His Asp His 
145                 150                 155                 160 


Gly Ser Leu Gln Pro Pro Pro Pro Arg Leu Lys 
                165                 170     


<210>  1367
<211>  1969
<212>  DNA
<213>  Homosapiens

<400>  1367
ggagaccctg tgcccctaaa tcgcggtcca ctgcgcgcgt caggtttcta gaagcagggt     60

agaacagacg gcagacacct agcccaggct ggtgttgtta ctaaacaatg gcagctggtg    120

agccaagggt gaccagggcc ctgaactcgg tggcccagct ttgagggaag caaaattgtt    180

ctcaattgtg gaagaggaga atttggacag cagaacaaaa aaggaagaca gcctcttgga    240

gcagatacat ttgtcacagg aagccacatc aaaccctggg gcctttgctg ggcctctcca    300

tctgcccagt tactgggagg tagatagccc caggaaggaa tccagtcagg cctgggcacc    360

aggccaggag tggataaagc tagaaagaga caccacagaa gagaagatgt ttgaacagct    420

gaagccaatc gaacctagag attgctggag ggaggcacgg gtgaagaaga agccagtcac    480

ctttgaggat gtggcagtga atttcaccca ggaagagtgg gactgtctag atgccagcca    540

gagggtcctt taccaggatg ttatgtcgga aacctttaag aatctaacat ctgtggccag    600

aatctttctg cataagccag agctaatcac caagcttgag caagaagagg aacagtggag    660

agagtttgtc catctcccaa acacagaagg cctttcagaa ggcaagaaga aagagcttcg    720

agaacaacat cccagtctga gagatgaggg gactagtgat gacaaggtct tccttgcatg    780

cagaggggcc ggccagtgcc ccctatctgc cccagctggg actatggaca ggacccgggt    840

gcttcaagca tcccaggctg ggccaccctt tttttgctac acctgtggca aatgtttcag    900

caggcgctcc tacctctata gccaccagtt tgttcacaat cccaagctga ctaacagctg    960

cagtcagtgt gggaagttgt ttcggagccc caagtccctc agctatcaca gacgcatgca   1020

tcttggggag aggcccttct gttgcacgct ctgtgacaag acctactgtg atgcttctgg   1080

actaagtcgt caccgccgcg tccatctggg ttaccggccc cattcatgct ctgtgtgtgg   1140

gaagagcttc cgggaccagt ctgagctcaa acgccaccag aagatacacc aaaaccagga   1200

gccagtggat ggaaaccagg agtgtacttt gaggattcca ggcacccagg ctgaattcca   1260

gacacccatc gccagaagcc agaggtccat ccaggggctt ttggatgtga accatgcacc   1320

agtggccagg tcccaggaac ccatatttag aactgagggt cctatggccc agaaccaggc   1380

atctgtactt aagaaccaag cacctgtgac caggacccag gcacccatca ctggaaccct   1440

ctgtcaggat gccagatcca actctcatcc agtgaagccc tcaagactca atgtcttctg   1500

ttgcccccat tgttctttga cttttagcaa gaaatcctat ctctccagac accagaaggc   1560

ccacctcaca gagccgccca actactgctt ccattgcagc aagtctttca gctcattttc   1620

caggctggtc agacaccagc agacccactg gaagcagaag agctaccttt gccctatctg   1680

tgacctctcc tttggggaga aagagggcct tatggatcac tggaggggct ataaaggcaa   1740

ggacctgtgc cagagcagcc accataaatg ccgggtgatc ctgggccagt ggcttggctt   1800

ctctcatgat gtccccacta tggctgggga ggaatggaag catggaggtg atcaatctcc   1860

ccccaggatc cataccccca ggagaagagg cctaagagag aaggcctgca aaggagacaa   1920

aacaaaggag gcagtgagca tcttgaaaca taaataaatg gcctttctg               1969


<210>  1368
<211>  516
<212>  PRT
<213>  Homosapiens

<400>  1368

Met Phe Glu Gln Leu Lys Pro Ile Glu Pro Arg Asp Cys Trp Arg Glu 
1               5                   10                  15      


Ala Arg Val Lys Lys Lys Pro Val Thr Phe Glu Asp Val Ala Val Asn 
            20                  25                  30          


Phe Thr Gln Glu Glu Trp Asp Cys Leu Asp Ala Ser Gln Arg Val Leu 
        35                  40                  45              


Tyr Gln Asp Val Met Ser Glu Thr Phe Lys Asn Leu Thr Ser Val Ala 
    50                  55                  60                  


Arg Ile Phe Leu His Lys Pro Glu Leu Ile Thr Lys Leu Glu Gln Glu 
65                  70                  75                  80  


Glu Glu Gln Trp Arg Glu Phe Val His Leu Pro Asn Thr Glu Gly Leu 
                85                  90                  95      


Ser Glu Gly Lys Lys Lys Glu Leu Arg Glu Gln His Pro Ser Leu Arg 
            100                 105                 110         


Asp Glu Gly Thr Ser Asp Asp Lys Val Phe Leu Ala Cys Arg Gly Ala 
        115                 120                 125             


Gly Gln Cys Pro Leu Ser Ala Pro Ala Gly Thr Met Asp Arg Thr Arg 
    130                 135                 140                 


Val Leu Gln Ala Ser Gln Ala Gly Pro Pro Phe Phe Cys Tyr Thr Cys 
145                 150                 155                 160 


Gly Lys Cys Phe Ser Arg Arg Ser Tyr Leu Tyr Ser His Gln Phe Val 
                165                 170                 175     


His Asn Pro Lys Leu Thr Asn Ser Cys Ser Gln Cys Gly Lys Leu Phe 
            180                 185                 190         


Arg Ser Pro Lys Ser Leu Ser Tyr His Arg Arg Met His Leu Gly Glu 
        195                 200                 205             


Arg Pro Phe Cys Cys Thr Leu Cys Asp Lys Thr Tyr Cys Asp Ala Ser 
    210                 215                 220                 


Gly Leu Ser Arg His Arg Arg Val His Leu Gly Tyr Arg Pro His Ser 
225                 230                 235                 240 


Cys Ser Val Cys Gly Lys Ser Phe Arg Asp Gln Ser Glu Leu Lys Arg 
                245                 250                 255     


His Gln Lys Ile His Gln Asn Gln Glu Pro Val Asp Gly Asn Gln Glu 
            260                 265                 270         


Cys Thr Leu Arg Ile Pro Gly Thr Gln Ala Glu Phe Gln Thr Pro Ile 
        275                 280                 285             


Ala Arg Ser Gln Arg Ser Ile Gln Gly Leu Leu Asp Val Asn His Ala 
    290                 295                 300                 


Pro Val Ala Arg Ser Gln Glu Pro Ile Phe Arg Thr Glu Gly Pro Met 
305                 310                 315                 320 


Ala Gln Asn Gln Ala Ser Val Leu Lys Asn Gln Ala Pro Val Thr Arg 
                325                 330                 335     


Thr Gln Ala Pro Ile Thr Gly Thr Leu Cys Gln Asp Ala Arg Ser Asn 
            340                 345                 350         


Ser His Pro Val Lys Pro Ser Arg Leu Asn Val Phe Cys Cys Pro His 
        355                 360                 365             


Cys Ser Leu Thr Phe Ser Lys Lys Ser Tyr Leu Ser Arg His Gln Lys 
    370                 375                 380                 


Ala His Leu Thr Glu Pro Pro Asn Tyr Cys Phe His Cys Ser Lys Ser 
385                 390                 395                 400 


Phe Ser Ser Phe Ser Arg Leu Val Arg His Gln Gln Thr His Trp Lys 
                405                 410                 415     


Gln Lys Ser Tyr Leu Cys Pro Ile Cys Asp Leu Ser Phe Gly Glu Lys 
            420                 425                 430         


Glu Gly Leu Met Asp His Trp Arg Gly Tyr Lys Gly Lys Asp Leu Cys 
        435                 440                 445             


Gln Ser Ser His His Lys Cys Arg Val Ile Leu Gly Gln Trp Leu Gly 
    450                 455                 460                 


Phe Ser His Asp Val Pro Thr Met Ala Gly Glu Glu Trp Lys His Gly 
465                 470                 475                 480 


Gly Asp Gln Ser Pro Pro Arg Ile His Thr Pro Arg Arg Arg Gly Leu 
                485                 490                 495     


Arg Glu Lys Ala Cys Lys Gly Asp Lys Thr Lys Glu Ala Val Ser Ile 
            500                 505                 510         


Leu Lys His Lys 
        515     


<210>  1369
<211>  1969
<212>  DNA
<213>  Homosapiens

<400>  1369
ggagaccctg tgcccctaaa tcgcggtcca ctgcgcgcgt caggtttcta gaagcagggt     60

agaacagagg gcagacacct agcccaggct ggtgttgtta ctaaacaatg gcagctggtg    120

agccaagggt gaccagggcc ctgaactctg tggcccagct ttgagggaag caaaattgtt    180

ctcaattgtg gaagaggaga atttggacag cagaacaaaa aaggaagaca gcctcttgga    240

gcagatacat ttgtcacagg aagccacatc aaaccctggg gcctttgctg ggcctctcca    300

tctgcccagt tactgggagg tagatagccc caggaaggaa tccagtcagg cctgggcacc    360

aggccaggag tggataaagc tagaaagaga caccacagaa gagaagatgt ttgaacagct    420

gaagccaatc gaacctagag attgctggag ggaggcacgg gtgaagaaga agccagtcac    480

ctttgaggat gtggcagtga atttcaccca ggaagagtgg gactgtctag atgccagcca    540

gagggtcctt taccaggatg ttatgtcgga aacctttaag aatctaacat ctgtggccag    600

aatctttctg cataagccag agctaatcac caagcttgag caagaagagg aacagtggag    660

agagtttgtc catctcccaa acacagaagg cctttcagaa ggcaagaaga aagagcttcg    720

agaacaacat cccagtctga gagatgaggg gactagtgat gacaaggtct tccttgcatg    780

cagaggggcc ggccagtgcc ccctatctgc cccagctggg actatggaca ggacccgggt    840

gcttcaagca tcccaggctg ggccaccctt tttttgctac acctgtggca aatgtttcag    900

caggcgctcc tacctctata gccaccagtt tgttcacaat cccaagctga ctaacagctg    960

cagtcagtgt gggaagttgt ttcggagccc caagtccctc agctatcaca gacgcatgca   1020

tcttggggag aggcccttct gttgcacgct ctgtgacaag acctactgtg atgcttctgg   1080

actaagtcgt caccgccgcg tccatctggg ttaccggccc cattcatgct ctgtgtgtgg   1140

gaagagcttc cgggaccagt ctgagctcaa acgccaccag aagatacacc aaaaccagga   1200

gccagtggat ggaaaccagg agtgtacttt gaggattcca ggcacccagg ctgaattcca   1260

gacacccatc gccagaagcc agaggtccat ccaggggctt ttggatgtga accatgcacc   1320

agtggccagg tcccaggaac ccatatttag aactgagggt cctatggccc agaaccaggc   1380

atctgtactt aagaaccaag cacctgtgac caggacccag gcacccatca ctggaaccct   1440

ctgtcaggat gccagatcca actctcatcc agtgaagccc tcaagactca atgtcttctg   1500

ttgcccccat tgttctttga cttttagcaa gaaatcctat ctctccagac accagaaggc   1560

ccacctcaca gagccgccca actactgctt ccattgcagc aagtctttca gctcattttc   1620

caggctggtc agacaccagc agacccactg gaagcagaag agctaccttt gccctatctg   1680

tgacctctcc tttggggaga aagagggcct tatggatcac tggaggggct ataaaggcaa   1740

ggacctgtgc cagagcagcc accataaatg ccgggtgatc ctgggccagt ggcttggctt   1800

ctctcatgat gtccccacta tggctgggga ggaatggaag catggaggtg atcaatctcc   1860

ccccaggatc cataccccca ggagaagagg cctaagagag aaggcctgca aaggagacaa   1920

aacaaaggag gcagtgagca tcttgaaaca taaataaatg gcctttctg               1969


<210>  1370
<211>  516
<212>  PRT
<213>  Homosapiens

<400>  1370

Met Phe Glu Gln Leu Lys Pro Ile Glu Pro Arg Asp Cys Trp Arg Glu 
1               5                   10                  15      


Ala Arg Val Lys Lys Lys Pro Val Thr Phe Glu Asp Val Ala Val Asn 
            20                  25                  30          


Phe Thr Gln Glu Glu Trp Asp Cys Leu Asp Ala Ser Gln Arg Val Leu 
        35                  40                  45              


Tyr Gln Asp Val Met Ser Glu Thr Phe Lys Asn Leu Thr Ser Val Ala 
    50                  55                  60                  


Arg Ile Phe Leu His Lys Pro Glu Leu Ile Thr Lys Leu Glu Gln Glu 
65                  70                  75                  80  


Glu Glu Gln Trp Arg Glu Phe Val His Leu Pro Asn Thr Glu Gly Leu 
                85                  90                  95      


Ser Glu Gly Lys Lys Lys Glu Leu Arg Glu Gln His Pro Ser Leu Arg 
            100                 105                 110         


Asp Glu Gly Thr Ser Asp Asp Lys Val Phe Leu Ala Cys Arg Gly Ala 
        115                 120                 125             


Gly Gln Cys Pro Leu Ser Ala Pro Ala Gly Thr Met Asp Arg Thr Arg 
    130                 135                 140                 


Val Leu Gln Ala Ser Gln Ala Gly Pro Pro Phe Phe Cys Tyr Thr Cys 
145                 150                 155                 160 


Gly Lys Cys Phe Ser Arg Arg Ser Tyr Leu Tyr Ser His Gln Phe Val 
                165                 170                 175     


His Asn Pro Lys Leu Thr Asn Ser Cys Ser Gln Cys Gly Lys Leu Phe 
            180                 185                 190         


Arg Ser Pro Lys Ser Leu Ser Tyr His Arg Arg Met His Leu Gly Glu 
        195                 200                 205             


Arg Pro Phe Cys Cys Thr Leu Cys Asp Lys Thr Tyr Cys Asp Ala Ser 
    210                 215                 220                 


Gly Leu Ser Arg His Arg Arg Val His Leu Gly Tyr Arg Pro His Ser 
225                 230                 235                 240 


Cys Ser Val Cys Gly Lys Ser Phe Arg Asp Gln Ser Glu Leu Lys Arg 
                245                 250                 255     


His Gln Lys Ile His Gln Asn Gln Glu Pro Val Asp Gly Asn Gln Glu 
            260                 265                 270         


Cys Thr Leu Arg Ile Pro Gly Thr Gln Ala Glu Phe Gln Thr Pro Ile 
        275                 280                 285             


Ala Arg Ser Gln Arg Ser Ile Gln Gly Leu Leu Asp Val Asn His Ala 
    290                 295                 300                 


Pro Val Ala Arg Ser Gln Glu Pro Ile Phe Arg Thr Glu Gly Pro Met 
305                 310                 315                 320 


Ala Gln Asn Gln Ala Ser Val Leu Lys Asn Gln Ala Pro Val Thr Arg 
                325                 330                 335     


Thr Gln Ala Pro Ile Thr Gly Thr Leu Cys Gln Asp Ala Arg Ser Asn 
            340                 345                 350         


Ser His Pro Val Lys Pro Ser Arg Leu Asn Val Phe Cys Cys Pro His 
        355                 360                 365             


Cys Ser Leu Thr Phe Ser Lys Lys Ser Tyr Leu Ser Arg His Gln Lys 
    370                 375                 380                 


Ala His Leu Thr Glu Pro Pro Asn Tyr Cys Phe His Cys Ser Lys Ser 
385                 390                 395                 400 


Phe Ser Ser Phe Ser Arg Leu Val Arg His Gln Gln Thr His Trp Lys 
                405                 410                 415     


Gln Lys Ser Tyr Leu Cys Pro Ile Cys Asp Leu Ser Phe Gly Glu Lys 
            420                 425                 430         


Glu Gly Leu Met Asp His Trp Arg Gly Tyr Lys Gly Lys Asp Leu Cys 
        435                 440                 445             


Gln Ser Ser His His Lys Cys Arg Val Ile Leu Gly Gln Trp Leu Gly 
    450                 455                 460                 


Phe Ser His Asp Val Pro Thr Met Ala Gly Glu Glu Trp Lys His Gly 
465                 470                 475                 480 


Gly Asp Gln Ser Pro Pro Arg Ile His Thr Pro Arg Arg Arg Gly Leu 
                485                 490                 495     


Arg Glu Lys Ala Cys Lys Gly Asp Lys Thr Lys Glu Ala Val Ser Ile 
            500                 505                 510         


Leu Lys His Lys 
        515     


<210>  1371
<211>  1188
<212>  DNA
<213>  Homosapiens

<400>  1371
atggcgcccc gaagcctcct cctgctgctc tcaggggccc tggccctgac cgatacttgg     60

gcgggctccc actccttgag gtatttcagc accgctgtgt cgcggcccgg ccgcggggag    120

ccccgctaca tcgccgtgga gtacgtagac gacacgcaat tcctgcggtt cgacagcgac    180

gccgcgattc cgaggatgga gccgcgggag ccgtgggtgg agcaagaggg gccgcagtat    240

tgggagtgga ccacagggta cgccaaggcc aacgcacaga ctgaccgagt ggccctgagg    300

aacctgctcc gccgctacaa ccagagcgag gctgggtctc acaccctcca gggaatgaat    360

ggctgcgaca tggggcccga cggacgcctc ctccgcgggt atcaccagca cgcgtacgac    420

ggcaaggatt acatctccct gaacgaggac ctgcgctcct ggaccgcggc ggacaccgtg    480

gctcagatca cccagcgctt ctatgaggca gaggaatatg cagaggagtt caggacctac    540

ctggagggcg agtgcctgga gttgctccgc agatacttgg agaatgggaa ggagacgcta    600

cagcgcgcag atcctccaaa ggcacacgtt gcccaccacc ccatctctga ccatgaggcc    660

accctgaggt gctgggccct gggcttctac cctgcggaga tcacgctgac ctggcagcgg    720

gatggggagg aacagaccca ggacacagag cttgtggaga ccaggcctgc aggggatgga    780

accttccaga agtgggccgc tgtggtggtg ccttctggag aggaacagag atacacatgc    840

catgtgcagc acgaggggct gccccagccc ctcatcctga gatgggagca gtctccccag    900

cccaccatcc ccatcgtggg catcgttgct ggccttgttg tccttggagc tgtggtcact    960

ggagctgtgg tcgctgctgt gatgtggagg aagaagagct cagatagaaa cagagggagc   1020

tactctcagg ctgcagtcac tgacagtgcc cagggctctg gggtgtctct cacagctaat   1080

aaagtgtgag acagcttcct tgtgtgggac tgagaagcaa gatatcaatg tagcagaatt   1140

gcacttgtgc ctcacgaaca tacataaatt ttaaaaataa agaataaa                1188


<210>  1372
<211>  362
<212>  PRT
<213>  Homosapiens

<400>  1372

Met Ala Pro Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 
1               5                   10                  15      


Thr Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro 
    50                  55                  60                  


Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr 
65                  70                  75                  80  


Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg 
                85                  90                  95      


Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly 
        115                 120                 125             


Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val 
145                 150                 155                 160 


Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 
                165                 170                 175     


Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr 
            180                 185                 190         


Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Ala 
        195                 200                 205             


His Val Ala His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg 
225                 230                 235                 240 


Asp Gly Glu Glu Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Gln Pro Leu Ile Leu Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly Ala Val Val Thr 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys Ser Ser Asp Arg 
                325                 330                 335     


Asn Arg Gly Ser Tyr Ser Gln Ala Ala Val Thr Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Gly Val Ser Leu Thr Ala Asn Lys Val 
        355                 360         


<210>  1373
<211>  342
<212>  DNA
<213>  Homosapiens

<400>  1373
atgaaccaca ctgcccaaac cttcttcatt cctgccaaca gtggctgccc tcccccgccc     60

cccaacccca gctatgagat gctcaaggag gagcatgagg tggctgtgct gggggcgccc    120

cacaaccctg ctcccccaat gtccaccatg atccatatct gcagcgagac ctccgtgtct    180

gactatgttg tctggtccct gtccaacatc ctcttcatga acccccactg cctgggattc    240

atagcattca cctactccct gaagtctagg gacaggaaga tggttggaga cctgactggg    300

gcccaggcct atgcctccac tgccaagtac ctgaacatct ga                       342


<210>  1374
<211>  2033
<212>  DNA
<213>  Homosapiens

<400>  1374
caaggagcac aggtcctcgt tcaggacgat gtaatccttg ccatcgtaag caagctggtg     60

atacccgcgg agtaggcgcc cgtccgaccc cacgtcgcag acagacatcc tctagatggg    120

tgtgagaccc tggccccgcc cccgcggcca gccccgccca ccgagccccg ccctcgccag    180

gaccaacctg cggggatttt ggctgaaaat gaaaccgggt aacggctcct gggcctctcc    240

cgggtcaagg gtctccaggt cccgctgcct cggcgtggat ctcggaccca gagactcggg    300

gagacccggg cggtccgtgg gggatgtgga ggggtagtga cctgcgcccc cggccggtgt    360

cactcacagg cctcactctg gttgtagtag ccgctcaggg tccgcaggtt cactcggtaa    420

aactgtgctt tggccttggc ggtccctgtc tcctcttccc aatattccgg cccctcctgc    480

tccatccacg gcgcccgcgg ctccatcctg ggactcgtgg cgtcgctgtc gagccgcacg    540

cactgcgtgt cgtccacgtc gcccacggag aggaagcggg gatccgcgcg gccgggccgg    600

gacatggtgg tgtggaaata cctcaaggag taagcctggg agcaaggagg gggctgagac    660

cctcccgacc ctcctcccgg caccgcaacc gggttcctgc gcccccgccg ggcaggcccc    720

tagctactcc ccacagacgc cgtttccctc ccgaccccgc actcacctgc ccaggtctgg    780

gtcaggacca gggcccccga gagcagcaga agcagggttc ggggcgccat gacaccatcc    840

tcggcgactg ggaagaatcg gagtcccggt gggtgcgtgg gaactttaga accgggaccg    900

cggctacatt gattggcttc tctagaaacc cgacactcaa tgggagtgag aactggggca    960

gcccggtgag tacccaggaa gaaggacccg acacaggttg ggagagggag aagagaaacc   1020

ctgcaaagat ggggaatgcc cagcgctggg cctccccaat ccatacaccg cctttggggc   1080

ctgagatcct gagagccacg cctgaggccc tgggacttcg ccctgacccc gctacttctg   1140

tgccaagcgc tctgtctcaa tgtttccctg agtcttggcc caggagctgt ctgagaaacc   1200

agggagaaac cctcggaatg ggccccgtcc ctctctcttc actttgcatc acggaatccc   1260

cgtcccagaa ctggactccc tgcctcctac tccttacctg tccccgtgga ctcttctaga   1320

agaaaaatca ccccagggag cttgttgcca gagagtgagc ttgccctggg aatggaggtg   1380

tagagacagg gttttttgtt gttgttgttt gtttgttttt taaatctgga aaagttgtgc   1440

ctgagtgcat gagatagaat agagaccagt ttgctttttg tttattaact acagtgggta   1500

gcagaatctt ggtaactcct aatgatcagg aatctaatcg gccaaaaatg tgactttggt   1560

cccttgacat ataaatgtgt ctaaaagcat tacaacagga atcacaaagc tcctaagttt   1620

cactttccca gacaatgtat ctgtgactcc cgcttgtagt attttaaatt taccttcatt   1680

ccatagccct gagtttctgt gtgagtccag gacatctcct aatacaaggt agccactgtg   1740

ttactatatg ttgtaaccag gagccagtac ggactttatt catctcacag tggcaagcac   1800

tcaatgcagt cacaatgccc ctcaccagtg ctcatgcact gcctgttttt aggaagtatc   1860

cacttctaag tgttgtgtat attttatatg aacacttagt attttttaaa cctgattaac   1920

ataaaaaaat tagtttttag gcagacccac ataaggtatt aaaggccaac tgcaaagatc   1980

accctgcaag gctctgtaga ttgatgtatt aaaatatata aaacaatgtg ttt          2033


<210>  1375
<211>  1840
<212>  DNA
<213>  Homosapiens

<400>  1375
cccattaggt gacaggtttt tagagaagcc aatcacgtcg ccgcggtcct ggttctaaag     60

tcctcgctca cccacccgga ctcattctcc ccagacgcca aggatggtgg tcatggcgcc    120

ccgaaccctc ttcctgctgc tctcgggggc cctgaccctg accgagacct gggcgggctc    180

ccactccatg aggtatttca gcgccgccgt gtcccggccc ggccgcgggg agccccgctt    240

catcgccatg ggctacgtgg acgacacgca gttcgtgcgg ttcgacagcg actcggcgtg    300

tccgaggatg gagccgcggg cgccgtgggt ggagcaggag gggccggagt attgggaaga    360

ggagacacgg aacaccaagg cccacgcaca gactgacaga atgaacctgc agaccctgcg    420

cggctactac aaccagagcg aggccagttc tcacaccctc cagtggatga ttggctgcga    480

cctggggtcc gacggacgcc tcctccgcgg gtatgaacag tatgcctacg atggcaagga    540

ttacctcgcc ctgaacgagg acctgcgctc ctggaccgca gcggacactg cggctcagat    600

ctccaagcgc aagtgtgagg cggccaatgt ggctgaacaa aggagagcct acctggaggg    660

cacgtgcgtg gagtggctcc acagatacct ggagaacggg aaggagatgc tgcagcgcgc    720

ggaccccccc aagacacacg tgacccacca ccctgtcttt gactatgagg ccaccctgag    780

gtgctgggcc ctgggcttct accctgcgga gatcatactg acctggcagc gggatgggga    840

ggaccagacc caggacgtgg agctcgtgga gaccaggcct gcaggggatg gaaccttcca    900

gaagtgggca gctgtggtgg tgccttctgg agaggagcag agatacacgt gccatgtgca    960

gcatgagggg ctgccggagc ccctcatgct gagatggaag cagtcttccc tgcccaccat   1020

ccccatcatg ggtatcgttg ctggcctggt tgtccttgca gctgtagtca ctggagctgc   1080

ggtcgctgct gtgctgtgga gaaagaagag ctcagattga aaaggaggga gctactctca   1140

ggctgcaagt aagtatgaag gaggctgatc cctgagatcc ttgggatctt gtgtttggga   1200

gccatggggg agctcaccca ccccacaatt cctcctctgg ccacatctcc tgtggtctct   1260

gaccaggtgc tgtttttgtt ctactctagg cagtgacagt gcccagggct ctaatgtgtc   1320

tctcacggct tgtaaatgtg acaccccggg gggcctgatg tgtgtgggtt gttgagggga   1380

acaggggaca tagctgtgct atgaggtttc tttgacttca atgtattgag catgtgatgg   1440

gctgtttaaa gtgtcacccc tcactgtgac tgatatgaat ttgttcatga atatttttct   1500

gtagtgtgaa acagctgccc tgtgtgggac tgagtggcaa gtccctttgt gacttcaaga   1560

accctgactt ctctttgtgc agagaccagc ccacccctgt gcccaccatg accctcttcc   1620

tcatgctgaa ctgcattcct tccccaatca cctttcctgt tccagaaaag gggctgggat   1680

gtctccgtct ctgtctcaaa tttgtggtcc actgagctat aacttacttc tgtattaaaa   1740

ttagaatctg agtataaatt tactttttca aattatttcc aagagagatt gatgggttaa   1800

ttaaaggaga agattcctga aatttgagag acaaaataaa                         1840


<210>  1376
<211>  338
<212>  PRT
<213>  Homosapiens

<400>  1376

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


<210>  1377
<211>  1096
<212>  DNA
<213>  Homosapiens

<400>  1377
atggtgctca tggcgccccg aaccctcctc ctgctgctct caggggccct ggccctgacc     60

cagacctggg cgcgctccca ctccatgagg tatttctaca ccaccatgtc ccggcccggc    120

cgcggggagc cccgcttcat ctccgtcggc tacgtggacg atacgcagtt cgtgcggttc    180

gacagcgacg ccgcgagcca gaggatggag ccgcgggcgc cgtggatgga gcgggagggg    240

ccggagtatt gggaccggaa cacacagatc tgcaaggccc aggcacagac tgaacgagag    300

aacctgcgga tcgcgctccg ctactacaac cagagcgagg gcggttctca caccatgcag    360

gtgatgtatg gctgcgacgt ggggcccgac gggcgcttcc tccgcgggta tgaacagcac    420

gcctacgaca gcaaggatta catcgctctg aacgaggacc tgcgctcctg gaccgcggcg    480

gacatggcag ctcagatcac caagcgcaag tgggaggcgg cccgtcaggc ggagcagctg    540

agagcctacc tggagggcga gttcgtggag tggctccgca gatacctgga gaacgggaag    600

gagacgctgc agcgcgcgga cccccccaag acacatatga cccaccaccc catctctgac    660

catgaggcca ccctgaggtg ctgggccctg ggcttctacc ctgcggagat cacactgacc    720

tggcagcggg atggggagga ccagacccac acacggagct catggagacc aggcctgcag    780

gggatggaac cttccagaag tgggcggctg tggtggtgcc ttctggagag gagcagagat    840

acacctgcca tgtgcagcat gagggtctgc cagagcccct caccctgaga tgggagccat    900

cttcccagcc caccatcccc atcgtgggca tcgttgctgg cctggttcta cttgtagctg    960

tggtcactgg agctgtggtc gctgctgtaa tgtggaggaa gaagagctca gatagaaaag   1020

gagggagcta ctctcaggct gcaagcggca acagtgccca gggctctgat gtgtctctca   1080

cggcgtgaaa gtgtga                                                   1096


<210>  1378
<211>  3642
<212>  DNA
<213>  Homosapiens

<400>  1378
ggcacgagct ttggctggct agggagggga tgcaatgata taaacattta tcccctgata     60

cctcatgtta aaatctgatg cccactgtgg gacgtggggc ctaatggcca ccatttgggt    120

catggtgacc aatcttttat gaatagagag atactgccct ctcttgggaa tgaatgaatt    180

gttgctttat tattttccaa gagagctagt tgttaaaaag accctggcaa cttcctactc    240

tctctgttcc tctgttacca tgtgttctct gcatatacca gctcaccttt gtcttctgcc    300

atgagtggaa gcagcctgag gccctcacta aatgcgcaaa catttccaga catcagaatc    360

ttgagccaca tgaaccttgt ttatataaat tagtcagtct cagacatttc tttatagcaa    420

cacaaaatgg aaaaagataa cactcgcatc acaggtatgt gtctctggca gctagccacc    480

gttcttaaga tatccaggat ccactcagcc aagagtcttc tcatcagtac tctaaagaca    540

cttatcactc aagagagtct aaggttttta ggagaaacca gggacaaagt ctaaatgttt    600

ttgtgataac tcagattgcc cacttttctt tgaccacata tcttttacag gaaaaaggat    660

tgtaacagta aagaggtatt ggcatattat cagagtctca tccattcatt caaaattagg    720

ccagtttatc atcctcttgt atgaatatgt ctcccagaat gaaatcactc agctttgctg    780

acaacactca atcttaccag gttccaaaaa caagaatggt ctcagggaca tacagcttca    840

ctcttttagg catccagtat aattgaccta agtgacaata tcttctcttg ctcacaccac    900

ctttgaggag ttaagctaat attgaatttt tctcattata taaccctttg atttattcac    960

ttgccctcag ccactattcc tccctctgtc cctttatatc agttgtttcc aggtttggga   1020

gtgacattag gtttgtctgc tgggctggcc tagactgcag gcagcaatag tattctagca   1080

tgtcttccct cagtctagtc ttgatcatag agggtaggtt atataggtaa ggaactagtg   1140

ggggctatca agaccaccag gctatataac tctacttact gttaatccta acttttccag   1200

atgaaatgaa tacttgagaa ttcttacata aaggtataaa aatatagtta tggtttttgg   1260

cttagggata attcctgttt ctggcacttt tatttacatc cctattcctg gtactatggc   1320

ataacatatg aaaaaataaa tttgaggtga agtgtagtct ttattccagc atcctctcct   1380

cttcagaaga attgtatgta tcgtcataac agcatcgtcc tgatccatca ggtaaaagag   1440

aggatgctac ctagtggagt tattcttgca gccccactca tgttgacagc gagcacattc   1500

atgaagatat aaaagccagt ccttcatgtt tatattgccc aacaattaga ttggcagttt   1560

ttagacaaac aatgtttcaa ttgaccattt caattttcta tcaaattttc ccctgaggag   1620

gacatgtccc tctgcattgt tggccatttg aggctgtaaa gtgtgttttc ttgtgtaaag   1680

aagtgtgact cggcagtcca aattggtgca atctcttctt ttctggttct tgtatagccc   1740

ttgaagcatt gacatctacc cctggttgag catagcccaa tccagagtca gtgattttcc   1800

tgtcaagatc cattggcagc tcctttgggg ttgctggcat cattctggct tgccaggtat   1860

tatgatcaaa gccttcccac tagagaatct gtcacatctc catctgctgc ctctgtctgt   1920

tttcttgacc aacagtgaaa aaagagatta tgagaaataa gataaattac caaaattgtg   1980

aacaaaagag agattatcac taatgaccct taggaagtta aaaaacatta taagtgaata   2040

ctctgaaaaa cctgaagcca ataagttaga ccacttggat aaaaaggacc aattcgtgca   2100

gagatagaaa ttgccaaaac tgacccaaat taactggaaa acctgaagag aactgtgaac   2160

taagtcagaa attgaaaaac cttctcaaaa agaaatgcca aagcccagat atcttcactg   2220

gtgaattcta tcaaatattt tgaaagctct ttcagacaag aagagaggag ggaagacttt   2280

ccagcccatt tacagaactg gcattaccct catatcaaag tcacagcaag actcacagga   2340

aaagagtgcc atacaccagt gtcaccaata aacataaatg aaaacatcct taacaaacat   2400

tggcagataa tacaaagcca cataaaaaag gattacactc catgaccaat gggattcatc   2460

ccaggaacat atggttggat taacatttga aaatcagttc atggaatgca ctgtattaat   2520

ggaaaaaaag acataattat ctcaaaagat gcaggagaaa cagttgacaa aaatgttaac   2580

atcactcatg ttcataagtt tcaacaaaat aggaatggag gagaccttct tcactctgat   2640

aaagggcgtc tataaaaaac ccacagctaa aatcaaactt aatgaagaaa gactgaagac   2700

tgaatgcttt tctcctaaga tggggatcaa tgcaaggatg tccaatccca ccacttttat   2760

ttaatattat actggagatt gtatccagtg caataaggca gaaaattaaa aattaaaggc   2820

atccagataa aaaggaaaac atacaattct attcacagat aacatgaccc tgtctgtaga   2880

attcacaagc agataaaaac tggctagcac taataaatga atccagaagg gcccatagga   2940

tatcaaatca atataaaaat taattattaa catatttctc tatagaagca atgaaaatct   3000

caactttcct atcacagtag ttaccagaag agcgaaatag gaataaattt aggaagacag   3060

cagtgtttgt tcactgaaaa taaaaaaaca ttcctcagag aaattaaagg tctaaataaa   3120

tggagagatg cgagttggaa agctcgataa tactgttaag atggcagttc tcccccagta   3180

gatctatagg ttcaacacaa tccctatcaa aatcccagca ggattttata gaaaattgac   3240

aaaataggcc gggcgcggtg gctcatgccg gtaatcccag cactttggga ggctgaggcg   3300

ggcggatcat gagatcagga gatccagacc atcctggcta acacggtgaa accccgtctc   3360

tactaaaaat acaaaaaatt agccgggcgt ggtggcaggc tcctcgggag gctgaggcag   3420

aaaaatggca tgaacccggt aggcagaagt tgcagtgagc ggagatcgtg ccactgcact   3480

ccagcctggg tgacagagcg agactccgtc tcaaaaaaaa aaaaaaaaaa aaagaaaaga   3540

aaaaaagaaa agaaaattga caaaataatc ctaaaaatgt atatgaaaat gcagaggatg   3600

cagaagggcc aacacaaatt tggaaaaaaa aaaaaaaaaa aa                      3642


<210>  1379
<211>  1060
<212>  DNA
<213>  Homosapiens

<400>  1379
cacaaagcta ctaagtttga ctttcgcaga caatgtatct gtgactcccg cttgtttttt     60

acatttacct tcattccaca gccctgagtt actgggtgag tccaagacat ctcctcaata    120

taaagtagca cactgcgtta ctatatgttg caaccgggag ccagtacaga ctttattcac    180

ctcacagttg caagtgttca atgcagtcac aatgcccctc agcagtgctc atgtgctgcc    240

tgtttttagg aagtattcac gtctaagtgg tgtgtatatc ttataggaac acttagtatt    300

tttaaaacct gattaattaa aaaaaattag tttctaggca gtcccaaata tagtattaaa    360

ggccaactgc aaagaaggaa cactaagtgt tttttaaacc ttattaacat aaaaaacatt    420

agtttttagg cagtcctaca ttaggtatta aaggccaact gcaaagaaca ctgagcgagg    480

ctctgtagat ggatgtaata aaaatctata aaacaatgtg tttaaaccta agaattctac    540

tgctttccaa ttccttccct ctgctccttt tcctaacctc ctgcttctcc agcccttccc    600

tctgtccctt tcatccctca ggccctcctc tccccttagt ccccaccacc ctgtcacttc    660

taaattgtgg ctctagcatt gtcccattac ctgctacgtg actgttctct ccacagtggt    720

cctgctcctg tgagtcagag tgtgtcattt cctcacctaa aacactccag tggctccacc    780

tcggtcttgt gaagcttcta gaatgtcagg cacgtgagca tatgagggca tacctggttc    840

atcttaggca ctaaattttt gttgactgaa tgaatgaaat atgaatgtat taaattgcat    900

cacagaaagt tataaaatgt aaaacactga aaaattaaga aatattttat tttatgtaac    960

tagtgtgcat atcaattcat tccgagtctg ttgagcctgt gtatgaattt tataagattg   1020

cataacaaat tatcacaaac attgacttta aacaacaccc                         1060


<210>  1380
<211>  1538
<212>  DNA
<213>  Homosapiens

<400>  1380
atggccgtca tggcgccccg aaccctcctc ctgctactct cgggggccct ggccctgacc     60

cagacctggg cgggctccca ctccatgagg tatttcttca catccgtgtc ccggcccggc    120

cgcggggagc cccgcttcat cgccgtgggc tacgtggacg acacgcagtt cgtgcggttc    180

gacagcgacg ccgcgagcca gaggatggag ccgcgggcgc cgtggataga gcaggagggg    240

ccggagtatt gggaccagga gacacggaat gtgaaggccc agtcacagac tgaccgagtg    300

gacctgggga ccctgcgcgg ctactacaac cagagcgagg ccggttctca caccatccag    360

ataatgtatg gctgcgacgt ggggtcggac gggcgcttcc tccgcgggta ccggcaggac    420

gcctacgacg gcaaggatta catcgccctg aacgaggacc tgcgctcttg gaccgcggcg    480

gacatggcgg ctcagatcac caagcgcaag tgggaggcgg cccatgaggc ggagcagttg    540

agagcctacc tggatggcac gtgcgtggag tggctccgca gatacctgga gaacgggaag    600

gagacgctgc agcgcacgga cccccccaag acacatatga cccaccaccc catctctgac    660

catgaggcca ccctgaggtg ctgggccctg ggcttctacc ctgcggagat cacactgacc    720

tggcagcggg atggggagga ccagacccag gacacggagc tcgtggagac caggcctgca    780

ggggatggaa ccttccagaa gtgggcggct gtggtggtgc cttctggaga ggagcagaga    840

tacacctgcc atgtgcagca tgagggtctg cccaagcccc tcaccctgag atgggagctg    900

tcttcccagc ccaccatccc catcgtgggc atcattgctg gcctggttct ccttggagct    960

gtgatcactg gagctgtggt cgctgccgtg atgtggagga ggaagagctc agatagaaaa   1020

ggagggagtt acactcaggc tgcaagcagt gacagtgccc agggctctga tgtgtccctc   1080

acagcttgta aagtgtgaga cagctgcctt gtgtgggact gagaggcaag agttgttcct   1140

gcccttccct ttgtgacttg aagaaccctg actttgtttc tgcaaaggca cctgcatgtg   1200

tctgtgttcg tgtaggcata atgtgaggag gtggggagac caccccaccc ccatgtccac   1260

catgaccctc ttcccacgct gacctgtgct ccctccccaa tcatctttcc tgttccagag   1320

aggtggggct gaggtgtctc catctctgtc tcaacttcat ggtgcactga gctgtaactt   1380

cttccttccc tattaaaatt agaaccttag tataaattta ctttctcaaa ttcttgccat   1440

gagaggttga tgagttaatt aaaggagaag attcctaaaa tttgagagac aaaataaatg   1500

gaacacatga gaaccttcca aaaaaaaaaa aaaaaaaa                           1538


<210>  1381
<211>  365
<212>  PRT
<213>  Homosapiens

<400>  1381

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln 
                85                  90                  95      


Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Asp Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  1382
<211>  670
<212>  DNA
<213>  Homosapiens

<400>  1382
agaggaaaga accctgggaa cgggaggcga agggataatg agctggggat gggagcagtc     60

gcaggaagaa tcctctgcct ggagccggca ggctccaacc cctcagcttg agagtcagga    120

gccccatagt ccccacagca ataggaagca ccagctcctg gtcccgaaaa aaggagggcc    180

ccaactccag ggactgcggc ccgccctgga gctgagaaca cgcggactcc agggagagga    240

cagggcttca gggacccgag agccgctctg agcaccgggg gatgtgactg cctcagcggc    300

agagctggaa gggccctcga atgccattca caggaacagc ccaggaaccc agggacttca    360

gaagggctgg tttgtccgaa aagtgagagg aggcggagga gagagcctgc gaggtcaagc    420

tgcagagaac atgagcttct acctccagat gtgccagggt gcatctcaat aaacttggat    480

tttggccagg cgcggtggct caggcctgta atcccagctc tggaagctga aggatagctt    540

gagcccagga gttcgaggct gcagtgagct atgatctcac cactacactc cagcctgggt    600

gacagcaaga gatcttgtct cagaaataaa taaataaaat ttaaaaataa aaaaaaaaaa    660

aaaaaaaaaa                                                           670


<210>  1383
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  1383

Met Ser Trp Gly Trp Glu Gln Ser Gln Glu Glu Ser Ser Ala Trp Ser 
1               5                   10                  15      


Arg Gln Ala Pro Thr Pro Gln Leu Glu Ser Gln Glu Pro His Ser Pro 
            20                  25                  30          


His Ser Asn Arg Lys His Gln Leu Leu Val Pro Lys Lys Gly Gly Pro 
        35                  40                  45              


Gln Leu Gln Gly Leu Arg Pro Ala Leu Glu Leu Arg Thr Arg Gly Leu 
    50                  55                  60                  


Gln Gly Glu Asp Arg Ala Ser Gly Thr Arg Glu Pro Leu 
65                  70                  75          


<210>  1384
<211>  751
<212>  DNA
<213>  Homosapiens

<400>  1384
gggcgcagag ctggcgctct agcccacgga gttggttaac tcctctcacc ggcccctgga     60

aagggttcca agtcctttag tacccgacgc tgtctgggaa ttccgggcgt ttcggctcct    120

tggtcgcaga ggcaggaggc acccgaccgc atgtctgtca tggacctcgc caatacttgc    180

tccagctttc agtcggacct ggatttctgt tcagattgcg gctcggtcct gcctctgccc    240

ggggctcagg atacggtcac ctgtattcgc tgtggcttca acatcaacgt tcgggacttt    300

gaggggaagg ttgtgaagac ttcggttgtg ttccaccaac tggggacagc catgcctatg    360

tcggtggagg aagggcctga gtgccaggga cctgtggttg acaggcgctg ccctcgatgt    420

ggtcatgaag gaatggcata ccacaccaga cagatgcgtt cagccgatga agggcaaact    480

gtcttctaca cctgtaccaa ctgcaagttc caggagaagg aagactcttg acctttttcc    540

tgggcaactc tacagtccct ccctcctttc ggaaggtgaa ggatactggg tttttagatg    600

ccttgtccat cctgtctggt tgcaatgttt tgctcccaga agagaatcag atcatcatgt    660

ggggattacc attgttcctg gagtactcct acccttagtt gaatttcctt attaaagtta    720

tatttttcta taagaccctg acaaaaaaaa a                                   751


<210>  1385
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  1385

Met Ser Val Met Asp Leu Ala Asn Thr Cys Ser Ser Phe Gln Ser Asp 
1               5                   10                  15      


Leu Asp Phe Cys Ser Asp Cys Gly Ser Val Leu Pro Leu Pro Gly Ala 
            20                  25                  30          


Gln Asp Thr Val Thr Cys Ile Arg Cys Gly Phe Asn Ile Asn Val Arg 
        35                  40                  45              


Asp Phe Glu Gly Lys Val Val Lys Thr Ser Val Val Phe His Gln Leu 
    50                  55                  60                  


Gly Thr Ala Met Pro Met Ser Val Glu Glu Gly Pro Glu Cys Gln Gly 
65                  70                  75                  80  


Pro Val Val Asp Arg Arg Cys Pro Arg Cys Gly His Glu Gly Met Ala 
                85                  90                  95      


Tyr His Thr Arg Gln Met Arg Ser Ala Asp Glu Gly Gln Thr Val Phe 
            100                 105                 110         


Tyr Thr Cys Thr Asn Cys Lys Phe Gln Glu Lys Glu Asp Ser 
        115                 120                 125     


<210>  1386
<211>  867
<212>  DNA
<213>  Homosapiens

<400>  1386
gggcgcagag ctggcgctct agcccacgga gttggttaac tcctctcacc ggcccctgga     60

aagggttcca agtcctttag tacccgacgc tgtctgggaa ttccgggcgt ttcggctcct    120

tggtcgcaga ggcaggaggc gtgcgtggca ggagggttcg ggttatatac tcctaggtcc    180

tgggacagaa tagttacgac ctctgggaca ggaactcttc tctcttttgt taataaactt    240

ccaactccct cctcagaccc gaccgcatgt ctgtcatgga cctcgccaat acttgctcca    300

gctttcagtc ggacctggat ttctgttcag attgcggctc ggtcctgcct ctgcccgggg    360

ctcaggatac ggtcacctgt attcgctgtg gcttcaacat caacgttcgg gactttgagg    420

ggaaggttgt gaagacttcg gttgtgttcc accaactggg gacagccatg cctatgtcgg    480

tggaggaagg gcctgagtgc cagggacctg tggttgacag gcgctgccct cgatgtggtc    540

atgaaggaat ggcataccac accagacaga tgcgttcagc cgatgaaggg caaactgtct    600

tctacacctg taccaactgc aagttccagg agaaggaaga ctcttgacct ttttcctggg    660

caactctaca gtccctccct cctttcggaa ggtgaaggat actgggtttt tagatgcctt    720

gtccatcctg tctggttgca atgttttgct cccagaagag aatcagatca tcatgtgggg    780

attaccattg ttcctggagt actcctaccc ttagttgaat ttccttatta aagttatatt    840

tttctataag accctgacaa aaaaaaa                                        867


<210>  1387
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  1387

Met Ser Val Met Asp Leu Ala Asn Thr Cys Ser Ser Phe Gln Ser Asp 
1               5                   10                  15      


Leu Asp Phe Cys Ser Asp Cys Gly Ser Val Leu Pro Leu Pro Gly Ala 
            20                  25                  30          


Gln Asp Thr Val Thr Cys Ile Arg Cys Gly Phe Asn Ile Asn Val Arg 
        35                  40                  45              


Asp Phe Glu Gly Lys Val Val Lys Thr Ser Val Val Phe His Gln Leu 
    50                  55                  60                  


Gly Thr Ala Met Pro Met Ser Val Glu Glu Gly Pro Glu Cys Gln Gly 
65                  70                  75                  80  


Pro Val Val Asp Arg Arg Cys Pro Arg Cys Gly His Glu Gly Met Ala 
                85                  90                  95      


Tyr His Thr Arg Gln Met Arg Ser Ala Asp Glu Gly Gln Thr Val Phe 
            100                 105                 110         


Tyr Thr Cys Thr Asn Cys Lys Phe Gln Glu Lys Glu Asp Ser 
        115                 120                 125     


<210>  1388
<211>  1664
<212>  DNA
<213>  Homosapiens

<400>  1388
gcatttggtg ccgtggaagg gaaaaagggg gactgcagta tgcgtcacac ccggaagcgg     60

cgagccggaa gtggggttag ccaggttatc cccaggggtg gagaagcgga ggcccaggag    120

gagggggaat aaagaaggtg gaggatcctg gctaccactc tgaatccgat accgcttctc    180

ttagacctca gcgacagaaa aagggaaggg tgtctcatcc cccttcctcc tctcctccct    240

gtcctgagcc ttagccatgg ccgaggcagg ggctgggctg agcgagaccg tcactgagac    300

aacggttacc gtgacaaccg agcccgagaa ccggagcctt accatcaaac ttcggaaacg    360

gaagccagag aaaaaggtag aatggacaag tgacactgtg gacaatgaac acatgggccg    420

ccgctcatcc aaatgctgct gtatttatga gaaacctcgg gcctttggcg agagctccac    480

ggaaagtgat gaggaggaag aagagggctg tggtcataca cactgtgtac gtggccaccg    540

caaaggacgg cgtcgtgcaa ccctaggacc gacccccacc acccctcccc agcctcctga    600

cccttcccag ccccctccag ggccaatgca gcactaaatc cctctctcct ccagcattcc    660

tgtgtctgtc tggccctaaa tgtatccatg tggctacttc tccagccccc tccttccctc    720

tcttctgcct gatagaggga agaggaagag gaggacgaac agagatcctg aaattctgac    780

ttgctgctat tccagaaccc agcctcctgg gtttccccag tcctcatttt tcctcccaat    840

acccaccctt ctctctcgag ggatctaggc accttggtcc cagtgtcttc cttttgttct    900

cactgccaaa ctgcctgtcc tgggatctag ttatcttggc cctgcactct caacatgagt    960

agcgaacact taaattgggt tttcaacagt cccagctttc actgccaggg tcccagtcag   1020

attccaggaa tttgcgccct aactttgctt gctaatcctg gtttagagct atcccactaa   1080

aatatttaat cctaattctt agtccttgcc tgtgagatat gaggtcttac aggagacctc   1140

agagctccca gcccttctcc tcctgctaac ccttctcaca ccctcaagag gagttagaaa   1200

agaggtcctt gtcattctca cctcttatgg aaaatggaat aagaaataat catatccttt   1260

cttcccaccc ttctcctgtt atttaggatt tctgacaaag ctggcttgag attggtcact   1320

tagagccgac tgtctcctct gccttttgtt tttcagcttc agagacagat ccaatatagt   1380

cccagggacc tgggtctctg ggagaggaag gaagagggag ggagcaaaga gattggggta   1440

tgtcccctgt agtacactct tacctcttac ttcctagact ttgatttctc cggcagccca   1500

gatgttcagt tctcttggcc cctctctacc ccttactggg atccggtttt cattttccgg   1560

tccttttgcc atacacagtt acagagatca gtcaaatcca taccaccact gagatctcat   1620

ttattgccac agatgcacaa aataaataac ccaaaatcac aaaa                    1664


<210>  1389
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  1389

Met Ala Glu Ala Gly Ala Gly Leu Ser Glu Thr Val Thr Glu Thr Thr 
1               5                   10                  15      


Val Thr Val Thr Thr Glu Pro Glu Asn Arg Ser Leu Thr Ile Lys Leu 
            20                  25                  30          


Arg Lys Arg Lys Pro Glu Lys Lys Val Glu Trp Thr Ser Asp Thr Val 
        35                  40                  45              


Asp Asn Glu His Met Gly Arg Arg Ser Ser Lys Cys Cys Cys Ile Tyr 
    50                  55                  60                  


Glu Lys Pro Arg Ala Phe Gly Glu Ser Ser Thr Glu Ser Asp Glu Glu 
65                  70                  75                  80  


Glu Glu Glu Gly Cys Gly His Thr His Cys Val Arg Gly His Arg Lys 
                85                  90                  95      


Gly Arg Arg Arg Ala Thr Leu Gly Pro Thr Pro Thr Thr Pro Pro Gln 
            100                 105                 110         


Pro Pro Asp Pro Ser Gln Pro Pro Pro Gly Pro Met Gln His 
        115                 120                 125     


<210>  1390
<211>  2187
<212>  DNA
<213>  Homosapiens

<400>  1390
ggcgttacgc aaggcctggt gtttacctcc cgtgggagcc tcctccctcc ctataaagcc     60

tgatgtggtg gagagatttg acgagactga gactctggtt gaagagagag gcaatcccag    120

gagaggggcg gaaagcggca aaagttaatg cgggagtcgg agagaagggc atctacacag    180

caagcagcag gggcggcccg ccatctgcgc gctcgaaggc ggtcacggtg gtcgcggaag    240

gggcggcgtc cagatcctgg ctttccatgg atgcgcccga gctgggcccg gggctggtgg    300

agcgtctgga gcagctggcg acgtgtcctc tgtgcggggg ctccttcgag gacccggtgc    360

ttctggcgtg cgagcacagc ttctgccgcg cgtgtctggc ccgccgctgg gggactccgc    420

cggcgaccgg caccgaggct tcccccaccg cctgtccctg ctgcggcctg ccgtgtcccc    480

gccgcagcct gaggtctaat gtgcggctgg cggtggaggt gcgaatcagc cgcgagctgc    540

gagagaagct ggctgagcct ggggcccgtg cggggagacg ccgagggggg cgcatcccca    600

ccatgggctg cctggacctg cccggagagg atatgaggaa gacatggaga cgatttgaag    660

tcccaacatc caagtcatct aattcagagg atgatctccc tgaagattat ccagtggtca    720

aaaaaatgct tcatagactg acagccgacc tgaccctgga ccctgggacc gcacaccgcc    780

gcctgctcat ctccgccgac cgccgcagcg tacaactggc cccaccaggg acgcccgcgc    840

cccctgacgg ccccaagcgc ttcaatcagc tcccagctgt gctgggtgcg cagggcttcg    900

gggccggccg ccactgctgg gaggtggaga ctgcggacgc cgcctcctgc agagactctt    960

ctggggagga tgcggacgac gaggagagcc actatgcagt gggcgcggcc ggggaatcag   1020

tgcaacgcaa gggctgcgta aggctgtgcc ctgcgggggc cgtgtgggcc gtggagggcc   1080

gcggcggccg cctgtgggcc ctcacggcac ccgaacccac cctgctgggc ggtgttgagc   1140

ccccgccgcg gcgcattcgc gtggacctgg actgggagcg gggccgcgtg gccttctacg   1200

acggccgctc actcgacctg ctttacgcct tccaggcgcc tggccccctg ggggagcgca   1260

tcttcccgct gttctgcacc tgcgaccctc gtgctccgct ccgcattgta ccagcggaaa   1320

gctgagtctc gtctccaact agaagtttgg cccggccact ggccctgcag ctgctttttg   1380

ggggtggaat tccccactca tttctgggaa cacattcaca cgcccattgc aggagtatta   1440

atagcaaccc acattttcgc cccaaaataa tgagacctca cctggtctcc acgtttccac   1500

gtccctgctc aaaaccaaat ccattcctgc cttctggctc tcagaatctt ctctccccta   1560

cagctactac agtacttcct gacttctccc attcaaacca ttctaggcct gcaatgggga   1620

acaggccctc cccatcagta ttggtaaagt gaccatgatt cctacataga ggctctgctg   1680

gtcaaatact tgactcccac tcttgccact cctagctcca gaagggctca gggccttccc   1740

cacagatcta aggactgggc taccctgcct gtccactgag gtttctccta aaacaagagg   1800

cttgactctg gtctgggccc tgtggccctc tgggaagctt tgtacctctt ttgcaggatc   1860

cgggggtggg gagggacaag ctagttcccc aacctcctat gactgctttc tatgctcaca   1920

gccttttttc cataagaacc ttcttgaaac ttctccccgc acatactcac ggaaaggaac   1980

caatggtgct atttcccctc tctcctcctc aacctgggaa tacttcagac atctccaaac   2040

tcatccttgt gtatagtctc acacccttcc ccataagtat aaatgggccc atatttaaca   2100

cattttgtga ttttgggtta tttattttgt gcatctgtgg caataaatga gatctcagtg   2160

gtggtatgga aaaaaaaaaa aaaaaaa                                       2187


<210>  1391
<211>  420
<212>  PRT
<213>  Homosapiens

<400>  1391

Met Trp Trp Arg Asp Leu Thr Arg Leu Arg Leu Trp Leu Lys Arg Glu 
1               5                   10                  15      


Ala Ile Pro Gly Glu Gly Arg Lys Ala Ala Lys Val Asn Ala Gly Val 
            20                  25                  30          


Gly Glu Lys Gly Ile Tyr Thr Ala Ser Ser Arg Gly Gly Pro Pro Ser 
        35                  40                  45              


Ala Arg Ser Lys Ala Val Thr Val Val Ala Glu Gly Ala Ala Ser Arg 
    50                  55                  60                  


Ser Trp Leu Ser Met Asp Ala Pro Glu Leu Gly Pro Gly Leu Val Glu 
65                  70                  75                  80  


Arg Leu Glu Gln Leu Ala Thr Cys Pro Leu Cys Gly Gly Ser Phe Glu 
                85                  90                  95      


Asp Pro Val Leu Leu Ala Cys Glu His Ser Phe Cys Arg Ala Cys Leu 
            100                 105                 110         


Ala Arg Arg Trp Gly Thr Pro Pro Ala Thr Gly Thr Glu Ala Ser Pro 
        115                 120                 125             


Thr Ala Cys Pro Cys Cys Gly Leu Pro Cys Pro Arg Arg Ser Leu Arg 
    130                 135                 140                 


Ser Asn Val Arg Leu Ala Val Glu Val Arg Ile Ser Arg Glu Leu Arg 
145                 150                 155                 160 


Glu Lys Leu Ala Glu Pro Gly Ala Arg Ala Gly Arg Arg Arg Gly Gly 
                165                 170                 175     


Arg Ile Pro Thr Met Gly Cys Leu Asp Leu Pro Gly Glu Asp Met Arg 
            180                 185                 190         


Lys Thr Trp Arg Arg Phe Glu Val Pro Thr Ser Lys Ser Ser Asn Ser 
        195                 200                 205             


Glu Asp Asp Leu Pro Glu Asp Tyr Pro Val Val Lys Lys Met Leu His 
    210                 215                 220                 


Arg Leu Thr Ala Asp Leu Thr Leu Asp Pro Gly Thr Ala His Arg Arg 
225                 230                 235                 240 


Leu Leu Ile Ser Ala Asp Arg Arg Ser Val Gln Leu Ala Pro Pro Gly 
                245                 250                 255     


Thr Pro Ala Pro Pro Asp Gly Pro Lys Arg Phe Asn Gln Leu Pro Ala 
            260                 265                 270         


Val Leu Gly Ala Gln Gly Phe Gly Ala Gly Arg His Cys Trp Glu Val 
        275                 280                 285             


Glu Thr Ala Asp Ala Ala Ser Cys Arg Asp Ser Ser Gly Glu Asp Ala 
    290                 295                 300                 


Asp Asp Glu Glu Ser His Tyr Ala Val Gly Ala Ala Gly Glu Ser Val 
305                 310                 315                 320 


Gln Arg Lys Gly Cys Val Arg Leu Cys Pro Ala Gly Ala Val Trp Ala 
                325                 330                 335     


Val Glu Gly Arg Gly Gly Arg Leu Trp Ala Leu Thr Ala Pro Glu Pro 
            340                 345                 350         


Thr Leu Leu Gly Gly Val Glu Pro Pro Pro Arg Arg Ile Arg Val Asp 
        355                 360                 365             


Leu Asp Trp Glu Arg Gly Arg Val Ala Phe Tyr Asp Gly Arg Ser Leu 
    370                 375                 380                 


Asp Leu Leu Tyr Ala Phe Gln Ala Pro Gly Pro Leu Gly Glu Arg Ile 
385                 390                 395                 400 


Phe Pro Leu Phe Cys Thr Cys Asp Pro Arg Ala Pro Leu Arg Ile Val 
                405                 410                 415     


Pro Ala Glu Ser 
            420 


<210>  1392
<211>  1989
<212>  DNA
<213>  Homosapiens

<400>  1392
ggcgttacgc aaggcctggt gtttacctcc cgtgggagcc tcctccctcc ctataaagcc     60

tgatgtggtg gagagatttg acgagactga gactctggtt gaagagagag gcaatcccag    120

gagaggggcg gaaagcggca aaagttaatg cgggagtcgg agagaagggc atctacacag    180

caagcagcag gggcggcccg ccatctgcgc gctcgaaggc ggtcacggtg gtcgcggaag    240

gggcggcgtc cagatcctgg ctttccatgg atgcgcccga gctgggcccg gggctggtgg    300

agcgtctgga gcagctggcg acgtgtcctc tgtgcggggg ctccttcgag gacccggtgc    360

ttctggcgtg cgagcacagc ttctgccgcg cgtgtctggc ccgccgctgg gggactccgc    420

cggcgaccgg caccgaggct tcccccaccg cctgtccctg ctgcggcctg ccgtgtcccc    480

gccgcagcct gaggtctaat gtgcggctgg cggtggaggt gcgaatcagc cgcgagctgc    540

gagagaagct ggctgagcct ggggcccgtg cggggagacg ccgagggggg cgcatcccca    600

ccatgggctg cctggacctg cccggagagg atatgaggaa gacatggaga cgatttgaag    660

tcccaacatc caagtcatct aattcagagg atgatctccc tgaagattat ccagtggtca    720

aaaaaatgct tcatagactg acagccgacc tgaccctgga ccctgggacc gcacaccgcc    780

gcctgctcat ctccgccgac cgccgcagcg tacaactggc cccaccaggg acgcccgcgc    840

cccctgacgg ccccaagcgc ttcaatcagc tcccagctgt gctgggtgcg cagggcttcg    900

gggccggccg ccactgctgg gaggtggaga ctgcggacgc cgcctcctgc agagactctt    960

ctggggagga tgcggacgac gaggagagcc actatgcagt gggcgcggcc ggggaatcag   1020

tgcaacgcaa gggctgcgcg cctggccccc tgggggagcg catcttcccg ctgttctgca   1080

cctgcgaccc tcgtgctccg ctccgcattg taccagcgga aagctgagtc tcgtctccaa   1140

ctagaagttt ggcccggcca ctggccctgc agctgctttt tgggggtgga attccccact   1200

catttctggg aacacattca cacgcccatt gcaggagtat taatagcaac ccacattttc   1260

gccccaaaat aatgagacct cacctggtct ccacgtttcc acgtccctgc tcaaaaccaa   1320

atccattcct gccttctggc tctcagaatc ttctctcccc tacagctact acagtacttc   1380

ctgacttctc ccattcaaac cattctaggc ctgcaatggg gaacaggccc tccccatcag   1440

tattggtaaa gtgaccatga ttcctacata gaggctctgc tggtcaaata cttgactccc   1500

actcttgcca ctcctagctc cagaagggct cagggccttc cccacagatc taaggactgg   1560

gctaccctgc ctgtccactg aggtttctcc taaaacaaga ggcttgactc tggtctgggc   1620

cctgtggccc tctgggaagc tttgtacctc ttttgcagga tctgggggtg gggagggaca   1680

agctagttcc ccaacctcct atgactgctt tctatgctca cagccttttt tccataagaa   1740

ccttcttgaa acttctcccc gcacatactc acggaaagga accaatggtg ctatttcccc   1800

tctctcctcc tcaacctggg aatacttcag acatctccaa actcatcctt gtgtatagtc   1860

tcacaccctt ccccataagt ataaatgggc ccatatttaa cacattttgt gattttgggt   1920

tatttatttt gtgcatctgt ggcaataaat gagatctcag tggtggtatg gaaaaaaaaa   1980

aaaaaaaaa                                                           1989


<210>  1393
<211>  354
<212>  PRT
<213>  Homosapiens

<400>  1393

Met Trp Trp Arg Asp Leu Thr Arg Leu Arg Leu Trp Leu Lys Arg Glu 
1               5                   10                  15      


Ala Ile Pro Gly Glu Gly Arg Lys Ala Ala Lys Val Asn Ala Gly Val 
            20                  25                  30          


Gly Glu Lys Gly Ile Tyr Thr Ala Ser Ser Arg Gly Gly Pro Pro Ser 
        35                  40                  45              


Ala Arg Ser Lys Ala Val Thr Val Val Ala Glu Gly Ala Ala Ser Arg 
    50                  55                  60                  


Ser Trp Leu Ser Met Asp Ala Pro Glu Leu Gly Pro Gly Leu Val Glu 
65                  70                  75                  80  


Arg Leu Glu Gln Leu Ala Thr Cys Pro Leu Cys Gly Gly Ser Phe Glu 
                85                  90                  95      


Asp Pro Val Leu Leu Ala Cys Glu His Ser Phe Cys Arg Ala Cys Leu 
            100                 105                 110         


Ala Arg Arg Trp Gly Thr Pro Pro Ala Thr Gly Thr Glu Ala Ser Pro 
        115                 120                 125             


Thr Ala Cys Pro Cys Cys Gly Leu Pro Cys Pro Arg Arg Ser Leu Arg 
    130                 135                 140                 


Ser Asn Val Arg Leu Ala Val Glu Val Arg Ile Ser Arg Glu Leu Arg 
145                 150                 155                 160 


Glu Lys Leu Ala Glu Pro Gly Ala Arg Ala Gly Arg Arg Arg Gly Gly 
                165                 170                 175     


Arg Ile Pro Thr Met Gly Cys Leu Asp Leu Pro Gly Glu Asp Met Arg 
            180                 185                 190         


Lys Thr Trp Arg Arg Phe Glu Val Pro Thr Ser Lys Ser Ser Asn Ser 
        195                 200                 205             


Glu Asp Asp Leu Pro Glu Asp Tyr Pro Val Val Lys Lys Met Leu His 
    210                 215                 220                 


Arg Leu Thr Ala Asp Leu Thr Leu Asp Pro Gly Thr Ala His Arg Arg 
225                 230                 235                 240 


Leu Leu Ile Ser Ala Asp Arg Arg Ser Val Gln Leu Ala Pro Pro Gly 
                245                 250                 255     


Thr Pro Ala Pro Pro Asp Gly Pro Lys Arg Phe Asn Gln Leu Pro Ala 
            260                 265                 270         


Val Leu Gly Ala Gln Gly Phe Gly Ala Gly Arg His Cys Trp Glu Val 
        275                 280                 285             


Glu Thr Ala Asp Ala Ala Ser Cys Arg Asp Ser Ser Gly Glu Asp Ala 
    290                 295                 300                 


Asp Asp Glu Glu Ser His Tyr Ala Val Gly Ala Ala Gly Glu Ser Val 
305                 310                 315                 320 


Gln Arg Lys Gly Cys Ala Pro Gly Pro Leu Gly Glu Arg Ile Phe Pro 
                325                 330                 335     


Leu Phe Cys Thr Cys Asp Pro Arg Ala Pro Leu Arg Ile Val Pro Ala 
            340                 345                 350         


Glu Ser 
        


<210>  1394
<211>  1353
<212>  DNA
<213>  Homosapiens

<400>  1394
ggcgttacgc aaggcctggt gtttacctcc cgtgggagcc tcctccctcc ctataaagcc     60

tgatgtggtg gagagatttg acgagactga gactctggtt gaagagagag gcaatcccag    120

gagaggggcg gaaagcggca aaagttaatg cgggagtcgg agagaagggc atctacacag    180

caagcagcag gggcggcccg ccatctgcgc gctcgaaggc ggtcacggtg gtcgcggaag    240

gggcggcgtc cagatcctgg ctttccatgg atgcgcccga gctgggcccg gggctggtgg    300

agcgtctgga gcagctggcg acgtgtcctc tgtgcggggg ctccttcgag gacccggtgc    360

ttctggcgtg cgagcacagc ttctgccgcg cgtgtctggc ccgccgctgg gggactccgc    420

cggcgaccgg caccgaggct tcccccaccg cctgtccctg ctgcggcctg ccgtgtcccc    480

gccgcagcct gaggtctaat gtgcggctgg cggtggaggt gcgaatcagc cgcgagctgc    540

tttttggggg tggaattccc cactcatttc tgggaacaca ttcacacgcc cattgcagga    600

gtattaatag caacccacat tttcgcccca aaataatgag acctcacctg gtctccacgt    660

ttccacgtcc ctgctcaaaa ccaaatccat tcctgccttc tggctctcag aatcttctct    720

cccctacagc tactacagta cttcctgact tctcccattc aaaccattct aggcctgcaa    780

tggggaacag gccctcccca tcagtattgg taaagtgacc atgattccta catagaggct    840

ctgctggtca aatacttgac tcccactctt gccactccta gctccagaag ggctcagggc    900

cttccccaca gatctaagga ctgggctacc ctgcctgtcc actgaggttt ctcctaaaac    960

aagaggcttg actctggtct gggccctgtg gccctctggg aagctttgta cctcttttgc   1020

aggatctggg ggtggggagg gacaagctag ttccccaacc tcctatgact gctttctatg   1080

ctcacagcct tttttccata agaaccttct tgaaacttct ccccgcacat actcacggaa   1140

aggaaccaat ggtgctattt cccctctctc ctcctcaacc tgggaatact tcagacatct   1200

ccaaactcat ccttgtgtat agtctcacac ccttccccat aagtataaat gggcccatat   1260

ttaacacatt ttgtgatttt gggttattta ttttgtgcat ctgtggcaat aaatgagatc   1320

tcagtggtgg tatggaaaaa aaaaaaaaaa aaa                                1353


<210>  1395
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  1395

Met Trp Trp Arg Asp Leu Thr Arg Leu Arg Leu Trp Leu Lys Arg Glu 
1               5                   10                  15      


Ala Ile Pro Gly Glu Gly Arg Lys Ala Ala Lys Val Asn Ala Gly Val 
            20                  25                  30          


Gly Glu Lys Gly Ile Tyr Thr Ala Ser Ser Arg Gly Gly Pro Pro Ser 
        35                  40                  45              


Ala Arg Ser Lys Ala Val Thr Val Val Ala Glu Gly Ala Ala Ser Arg 
    50                  55                  60                  


Ser Trp Leu Ser Met Asp Ala Pro Glu Leu Gly Pro Gly Leu Val Glu 
65                  70                  75                  80  


Arg Leu Glu Gln Leu Ala Thr Cys Pro Leu Cys Gly Gly Ser Phe Glu 
                85                  90                  95      


Asp Pro Val Leu Leu Ala Cys Glu His Ser Phe Cys Arg Ala Cys Leu 
            100                 105                 110         


Ala Arg Arg Trp Gly Thr Pro Pro Ala Thr Gly Thr Glu Ala Ser Pro 
        115                 120                 125             


Thr Ala Cys Pro Cys Cys Gly Leu Pro Cys Pro Arg Arg Ser Leu Arg 
    130                 135                 140                 


Ser Asn Val Arg Leu Ala Val Glu Val Arg Ile Ser Arg Glu Leu Leu 
145                 150                 155                 160 


Phe Gly Gly Gly Ile Pro His Ser Phe Leu Gly Thr His Ser His Ala 
                165                 170                 175     


His Cys Arg Ser Ile Asn Ser Asn Pro His Phe Arg Pro Lys Ile Met 
            180                 185                 190         


Arg Pro His Leu Val Ser Thr Phe Pro Arg Pro Cys Ser Lys Pro Asn 
        195                 200                 205             


Pro Phe Leu Pro Ser Gly Ser Gln Asn Leu Leu Ser Pro Thr Ala Thr 
    210                 215                 220                 


Thr Val Leu Pro Asp Phe Ser His Ser Asn His Ser Arg Pro Ala Met 
225                 230                 235                 240 


Gly Asn Arg Pro Ser Pro Ser Val Leu Val Lys 
                245                 250     


<210>  1396
<211>  2049
<212>  DNA
<213>  Homosapiens

<400>  1396
atccatttgt tctcaagagg tagcaagaaa cagtatccac agtggactcc ggggctccta     60

cagacttggc acagcttcct acagtcttga aacagccctg ttgttctgtc atggccagtg    120

ggcagtttgt gaacaaactg caagaggaag tgatctgccc catctgcctg gacattctgc    180

agaaacctgt caccatcgac tgtgggcaca atttctgcct caaatgcatc actcagattg    240

gggaaacatc atgtggattt ttcaaatgtc ccctctgcaa aacttccgta aggaagaacg    300

caatcaggtt caactcgctg ttgcggaatc tggtggagaa aatccaagct ctacaagcct    360

ctgaggtgca gtccaaaagg aaagaggcta catgcccgag gcaccaggag atgttccact    420

atttctgcga ggatgatggg aagttcctct gttttgtgtg tcgtgaatcc aaggaccaca    480

aatcccataa tgtcagcttg atcgaagaag ctgcccagaa ttatcagggg cagattcaag    540

agcagatcca agtcttgcag caaaaggaga aggagacagt acaagtgaag gcacaaggtg    600

tacacagggt cgatgtcttc acggaccagg tagaacatga gaagcaaagg atcctcacag    660

aatttgaact cctgcatcaa gtcctagagg aggagaagaa tttcctgcta tcacggattt    720

actggctggg tcatgaggga acggaagcgg ggaaacacta tgttgcctcc actgagccac    780

agttgaacga tctcaagaag ctcgttgatt ccctgaagac caagcagaac atgccaccca    840

ggcagctgct ggaggatatc aaagtcgtct tgtgcagaag tgaagagttt cagtttctca    900

acccaacccc tgttcctctg gaactggaga aaaaactcag tgaagcaaaa tcaagacatg    960

actccatcac agggagccta aaaaaattca aagaccaact ccaggctgat aggaaaaaag   1020

atgaaaacag attcttcaaa agcatgaata aaaatgacat gaagagctgg ggcttgttac   1080

agaaaaataa tcataaaatg aacaaaacct cagagcccgg gtcatcttct gcaggcggca   1140

gaactacatc ggggccacca aatcaccact cttcagcccc atcccactcc ctgtttcggg   1200

cctcgtctgc tgggaaagtc acttttccag tatgtctcct ggcctcttat gatgagattt   1260

ctggtcaagg agcgagctct caggatacga agacatttga cgttgcgctg tccgaggagc   1320

tccatgcggc actgagtgag tggctgacag cgatccgggc ttggttttgt gaggttcctt   1380

caagctaagc cagctcagag aacacgggga gcggtggtgc tacacggact tcggagcata   1440

gagtggcgct gagtgagtgg ctgagaccga ccacggttct tgacttagtg gaattgggtc   1500

gaaggagtgg agaatgggag ggctcgggct actgagagtg gagatggggg cgggggtggt   1560

ggtgaagaga gttggagaag gaatggacga attcttgagc aaaaggaggg gaagagacaa   1620

tctccagcca cccgccccac gcttgacttc ttatcacttt ggctgtggtg ccgcctagtg   1680

gaaaaaggaa gtccctgcag cagtccccgc actctttaag cagctgttta ccgaaggcac   1740

cagttcagcc aggagtgaaa tccggagagg agcaacgcca gcctgggtca cagtccatca   1800

aaccccatga gcccgaccac tctcgctctt ccttacattc ccacgtcccc cttctctccc   1860

aacccctcat atcagcaagg gaaattaatt aatgagattt gataaatcag tagatagaat   1920

gaggtcccca ttctgaaata tttagcagac tggaaccacc acgcaagcct ctgtaggggg   1980

tggatggaga cacttctaac tttaataaac tgcgactgaa cgtggaaaaa aaaaaaaaaa   2040

aaaaaaaaa                                                           2049


<210>  1397
<211>  425
<212>  PRT
<213>  Homosapiens

<400>  1397

Met Ala Ser Gly Gln Phe Val Asn Lys Leu Gln Glu Glu Val Ile Cys 
1               5                   10                  15      


Pro Ile Cys Leu Asp Ile Leu Gln Lys Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Leu Lys Cys Ile Thr Gln Ile Gly Glu Thr Ser Cys 
        35                  40                  45              


Gly Phe Phe Lys Cys Pro Leu Cys Lys Thr Ser Val Arg Lys Asn Ala 
    50                  55                  60                  


Ile Arg Phe Asn Ser Leu Leu Arg Asn Leu Val Glu Lys Ile Gln Ala 
65                  70                  75                  80  


Leu Gln Ala Ser Glu Val Gln Ser Lys Arg Lys Glu Ala Thr Cys Pro 
                85                  90                  95      


Arg His Gln Glu Met Phe His Tyr Phe Cys Glu Asp Asp Gly Lys Phe 
            100                 105                 110         


Leu Cys Phe Val Cys Arg Glu Ser Lys Asp His Lys Ser His Asn Val 
        115                 120                 125             


Ser Leu Ile Glu Glu Ala Ala Gln Asn Tyr Gln Gly Gln Ile Gln Glu 
    130                 135                 140                 


Gln Ile Gln Val Leu Gln Gln Lys Glu Lys Glu Thr Val Gln Val Lys 
145                 150                 155                 160 


Ala Gln Gly Val His Arg Val Asp Val Phe Thr Asp Gln Val Glu His 
                165                 170                 175     


Glu Lys Gln Arg Ile Leu Thr Glu Phe Glu Leu Leu His Gln Val Leu 
            180                 185                 190         


Glu Glu Glu Lys Asn Phe Leu Leu Ser Arg Ile Tyr Trp Leu Gly His 
        195                 200                 205             


Glu Gly Thr Glu Ala Gly Lys His Tyr Val Ala Ser Thr Glu Pro Gln 
    210                 215                 220                 


Leu Asn Asp Leu Lys Lys Leu Val Asp Ser Leu Lys Thr Lys Gln Asn 
225                 230                 235                 240 


Met Pro Pro Arg Gln Leu Leu Glu Asp Ile Lys Val Val Leu Cys Arg 
                245                 250                 255     


Ser Glu Glu Phe Gln Phe Leu Asn Pro Thr Pro Val Pro Leu Glu Leu 
            260                 265                 270         


Glu Lys Lys Leu Ser Glu Ala Lys Ser Arg His Asp Ser Ile Thr Gly 
        275                 280                 285             


Ser Leu Lys Lys Phe Lys Asp Gln Leu Gln Ala Asp Arg Lys Lys Asp 
    290                 295                 300                 


Glu Asn Arg Phe Phe Lys Ser Met Asn Lys Asn Asp Met Lys Ser Trp 
305                 310                 315                 320 


Gly Leu Leu Gln Lys Asn Asn His Lys Met Asn Lys Thr Ser Glu Pro 
                325                 330                 335     


Gly Ser Ser Ser Ala Gly Gly Arg Thr Thr Ser Gly Pro Pro Asn His 
            340                 345                 350         


His Ser Ser Ala Pro Ser His Ser Leu Phe Arg Ala Ser Ser Ala Gly 
        355                 360                 365             


Lys Val Thr Phe Pro Val Cys Leu Leu Ala Ser Tyr Asp Glu Ile Ser 
    370                 375                 380                 


Gly Gln Gly Ala Ser Ser Gln Asp Thr Lys Thr Phe Asp Val Ala Leu 
385                 390                 395                 400 


Ser Glu Glu Leu His Ala Ala Leu Ser Glu Trp Leu Thr Ala Ile Arg 
                405                 410                 415     


Ala Trp Phe Cys Glu Val Pro Ser Ser 
            420                 425 


<210>  1398
<211>  1982
<212>  DNA
<213>  Homosapiens

<400>  1398
atccatttgt tctcaagagg tagcaagaaa cagtatccac agtggactcc ggggctccta     60

cagacttggc acagcttcct acagtcttga aacagccctg ttgttctgtc atggccagtg    120

ggcagtttgt gaacaaactg caagaggaag tgatctgccc catctgcctg gacattctgc    180

agaaacctgt caccatcgac tgtgggcaca atttctgcct caaatgcatc actcagattg    240

gggaaacatc atgtggattt ttcaaatgtc ccctctgcaa aacttccgta aggaagaacg    300

caatcaggtt caactcgctg ttgcggaatc tggtggagaa aatccaagct ctacaagcct    360

ctgaggtgca gtccaaaagg aaagaggcta catgcccgag gcaccaggag atgttccact    420

atttctgcga ggatgatggg aagttcctct gttttgtgtg tcgtgaatcc aaggaccaca    480

aatcccataa tgtcagcttg atcgaagaag ctgcccagaa ttatcagggg cagattcaag    540

agcagatcca agtcttgcag caaaaggaga aggagacagt acaagtgaag gcacaaggtg    600

tacacagggt cgatgtcttc acggaccagg tagaacatga gaagcaaagg atcctcacag    660

aatttgaact cctgcatcaa gtcctagagg aggagaagaa tttcctgcta tcacggattt    720

actggctggg tcatgaggga acggaagcgg ggaaacacta tgttgcctcc actgagccac    780

agttgaacga tctcaagaag ctcgttgatt ccctgaagac caagcagaac atgccaccca    840

ggcagctgct ggagaactgg agaaaaaact cagtgaagca aaatcaagac atgactccat    900

cacagggagc ctaaaaaaat tcaaagacca actccaggct gataggaaaa aagatgaaaa    960

cagattcttc aaaagcatga ataaaaatga catgaagagc tggggcttgt tacagaaaaa   1020

taatcataaa atgaacaaaa cctcagagcc cgggtcatct tctgcaggcg gcagaactac   1080

atcggggcca ccaaatcacc actcttcagc cccatcccac tccctgtttc gggcctcgtc   1140

tgctgggaaa gtcacttttc cagtatgtct cctggcctct tatgatgaga tttctggtca   1200

aggagcgagc tctcaggata cgaagacatt tgacgttgcg ctgtccgagg agctccatgc   1260

ggcactgagt gagtggctga cagcgatccg ggcttggttt tgtgaggttc cttcaagcta   1320

agccagctca gagaacacgg ggagcggtgg tgctacacgg acttcggagc atagagtggc   1380

gctgagtgag tggctgagac cgaccacggt tcttgactta gtggaattgg gtcgaaggag   1440

tggagaatgg gagggctcgg gctactgaga gtggagatgg gggcgggggt ggtggtgaag   1500

agagttggag aaggaatgga cgaattcttg agcaaaagga ggggaagaga caatctccag   1560

ccacccgccc cacgcttgac ttcttatcac tttggctgtg gtgccgccta gtggaaaaag   1620

gaagtccctg cagcagtccc cgcactcttt aagcagctgt ttaccgaagg caccagttca   1680

gccaggagtg aaatccggag aggagcaacg ccagcctggg tcacagtcca tcaaacccca   1740

tgagcccgac cactctcgct cttccttaca ttcccacgtc ccccttctct cccaacccct   1800

catatcagca agggaaatta attaatgaga tttgataaat cagtagatag aatgaggtcc   1860

ccattctgaa atatttagca gactggaacc accacgcaag cctctgtagg gggtggatgg   1920

agacacttct aactttaata aactgcgact gaacgtggaa aaaaaaaaaa aaaaaaaaaa   1980

aa                                                                  1982


<210>  1399
<211>  267
<212>  PRT
<213>  Homosapiens

<400>  1399

Met Ala Ser Gly Gln Phe Val Asn Lys Leu Gln Glu Glu Val Ile Cys 
1               5                   10                  15      


Pro Ile Cys Leu Asp Ile Leu Gln Lys Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Leu Lys Cys Ile Thr Gln Ile Gly Glu Thr Ser Cys 
        35                  40                  45              


Gly Phe Phe Lys Cys Pro Leu Cys Lys Thr Ser Val Arg Lys Asn Ala 
    50                  55                  60                  


Ile Arg Phe Asn Ser Leu Leu Arg Asn Leu Val Glu Lys Ile Gln Ala 
65                  70                  75                  80  


Leu Gln Ala Ser Glu Val Gln Ser Lys Arg Lys Glu Ala Thr Cys Pro 
                85                  90                  95      


Arg His Gln Glu Met Phe His Tyr Phe Cys Glu Asp Asp Gly Lys Phe 
            100                 105                 110         


Leu Cys Phe Val Cys Arg Glu Ser Lys Asp His Lys Ser His Asn Val 
        115                 120                 125             


Ser Leu Ile Glu Glu Ala Ala Gln Asn Tyr Gln Gly Gln Ile Gln Glu 
    130                 135                 140                 


Gln Ile Gln Val Leu Gln Gln Lys Glu Lys Glu Thr Val Gln Val Lys 
145                 150                 155                 160 


Ala Gln Gly Val His Arg Val Asp Val Phe Thr Asp Gln Val Glu His 
                165                 170                 175     


Glu Lys Gln Arg Ile Leu Thr Glu Phe Glu Leu Leu His Gln Val Leu 
            180                 185                 190         


Glu Glu Glu Lys Asn Phe Leu Leu Ser Arg Ile Tyr Trp Leu Gly His 
        195                 200                 205             


Glu Gly Thr Glu Ala Gly Lys His Tyr Val Ala Ser Thr Glu Pro Gln 
    210                 215                 220                 


Leu Asn Asp Leu Lys Lys Leu Val Asp Ser Leu Lys Thr Lys Gln Asn 
225                 230                 235                 240 


Met Pro Pro Arg Gln Leu Leu Glu Asn Trp Arg Lys Asn Ser Val Lys 
                245                 250                 255     


Gln Asn Gln Asp Met Thr Pro Ser Gln Gly Ala 
            260                 265         


<210>  1400
<211>  997
<212>  DNA
<213>  Homosapiens

<400>  1400
gtgtatgaaa aataatttca agtttaacaa acacaaggaa accgcagggt ccatgtcaaa     60

gctgatgagc tatttctgaa actcgtgcag aattgtggtt tgtgtggtct atgtcacggc    120

acccttgagg gagagtgggc aattgcctga acttggaggc tgtgtcctgt ccccaggctg    180

ctccagggct gcctccttcc gactgggcct tcttatctgg gactgttgag ggcaacaggc    240

cttccgaaga ccagtgaaga aggaggccct gcaaacagga ggctgacagg gtaggaacga    300

ggccatgatc cctttgcaga aggacaacca ggaggagggt gtctgcccca tctgccagga    360

gagcctgaag gaggccgtga gcaccaactg cggacatctc ttctgtcgag tgtgcctgac    420

acagcatgtg gagaaggcct cagcctctgg ggtcttctgc tgccccctct gccggaagcc    480

ctgttctgag gaggtgctag ggacaggcta tatctgcccc aaccaccaga agagggtgtg    540

caggttctgt gaggagagca gacttcttct atgtgtggaa tgcctggtgt cccctgaaca    600

catgtctcat catgaactga ccattgaaaa tgccctcagc cactacaagg aacgactcaa    660

tcgccggagc aggaagctca gaaaggacat tgcagaactt cagcggctca aggctcagca    720

ggagaagaaa ctgcaggctc tgcagcagtg gctgggccag ctggagcaca tgccagcaga    780

agcggccaga atccttgaca tctccagggc agtaacacag ctcagaagcc tggtcattga    840

tctggaaagg acggccaagg aattagacac caacacactg aagaatgctg gtgacttact    900

gaacaggagt gctccacaga aattagaggt tatttatccc cagttggaga aaggagtcag    960

tgaattgctt cttcagcccc ctcagaagct ctgaccc                             997


<210>  1401
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  1401

Met Ile Pro Leu Gln Lys Asp Asn Gln Glu Glu Gly Val Cys Pro Ile 
1               5                   10                  15      


Cys Gln Glu Ser Leu Lys Glu Ala Val Ser Thr Asn Cys Gly His Leu 
            20                  25                  30          


Phe Cys Arg Val Cys Leu Thr Gln His Val Glu Lys Ala Ser Ala Ser 
        35                  40                  45              


Gly Val Phe Cys Cys Pro Leu Cys Arg Lys Pro Cys Ser Glu Glu Val 
    50                  55                  60                  


Leu Gly Thr Gly Tyr Ile Cys Pro Asn His Gln Lys Arg Val Cys Arg 
65                  70                  75                  80  


Phe Cys Glu Glu Ser Arg Leu Leu Leu Cys Val Glu Cys Leu Val Ser 
                85                  90                  95      


Pro Glu His Met Ser His His Glu Leu Thr Ile Glu Asn Ala Leu Ser 
            100                 105                 110         


His Tyr Lys Glu Arg Leu Asn Arg Arg Ser Arg Lys Leu Arg Lys Asp 
        115                 120                 125             


Ile Ala Glu Leu Gln Arg Leu Lys Ala Gln Gln Glu Lys Lys Leu Gln 
    130                 135                 140                 


Ala Leu Gln Gln Trp Leu Gly Gln Leu Glu His Met Pro Ala Glu Ala 
145                 150                 155                 160 


Ala Arg Ile Leu Asp Ile Ser Arg Ala Val Thr Gln Leu Arg Ser Leu 
                165                 170                 175     


Val Ile Asp Leu Glu Arg Thr Ala Lys Glu Leu Asp Thr Asn Thr Leu 
            180                 185                 190         


Lys Asn Ala Gly Asp Leu Leu Asn Arg Ser Ala Pro Gln Lys Leu Glu 
        195                 200                 205             


Val Ile Tyr Pro Gln Leu Glu Lys Gly Val Ser Glu Leu Leu Leu Gln 
    210                 215                 220                 


Pro Pro Gln Lys Leu 
225                 


<210>  1402
<211>  2004
<212>  DNA
<213>  Homosapiens

<400>  1402
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca     60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa    120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt    180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc    240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct    300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga    360

ggaggatgtc tgccaagagc acggagggaa gatctacttc ttctgtgagg atgatgagat    420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct    480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa    540

agagagagag gagattcaag aaatccagtc aagagaaaat aaaaggatgc aagtcctcct    600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt    660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt    720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct    780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag    840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga    900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa    960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga   1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc   1080

ctcaaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct   1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg gtgagtatag acctggccca   1200

tggggcgagc tgcaccgtgg gcgtggtgag cgaggatgtg cagcggaagg gggagcttcg   1260

gctgcggcca gaggaggggg tgtgggctgt gaggctggct tggggcttcg tctcggctct   1320

gggctccttc cccacacggc tgaccctgaa ggagcagccc cggcaggtga gggtgtctct   1380

tgactatgag gtgggctggg tgaccttcac caacgctgtc acccgagagc ccatctacac   1440

cttcactgcc tccttcacta ggaaggtcat tcccttcttt gggctctggg gccgagggtc   1500

cagtttctcc ctgagctcct gagaaggagc agttacctac tctcctctaa gtacaggact   1560

cattcaaccc agtaccatgt ggcttgatcc ctggctgaat cacctggatg actcgggata   1620

gaaatgactg ctttagaaga tgggatgggg tcgggtggta agggatagaa gagaggactc   1680

tcaatctact gatcaagtcc tttccccaat gcccagtgga tggccagggt acctggggac   1740

tcaggctgct gccagttctg ctcaccacca tccgtgcttg gcacagaagt agctgcatag   1800

aaagagcact ggatttgaag tcagaagacc tggttcttga accagcctgt caaccagttg   1860

tatgacttta aacaaggcat ctcacctctt ttcatcttgt tttcttccaa taatgttaga   1920

gttcatgtaa tcacattctc tagaaccatt tagtttgtgt taactatgaa ccaagcagtg   1980

tggtgggcca ctggtggact tgga                                          2004


<210>  1403
<211>  481
<212>  PRT
<213>  Homosapiens

<400>  1403

Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Gly Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Ser 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Val Ser Ile Asp Leu Ala His Gly Ala Ser Cys Thr Val Gly Val Val 
    370                 375                 380                 


Ser Glu Asp Val Gln Arg Lys Gly Glu Leu Arg Leu Arg Pro Glu Glu 
385                 390                 395                 400 


Gly Val Trp Ala Val Arg Leu Ala Trp Gly Phe Val Ser Ala Leu Gly 
                405                 410                 415     


Ser Phe Pro Thr Arg Leu Thr Leu Lys Glu Gln Pro Arg Gln Val Arg 
            420                 425                 430         


Val Ser Leu Asp Tyr Glu Val Gly Trp Val Thr Phe Thr Asn Ala Val 
        435                 440                 445             


Thr Arg Glu Pro Ile Tyr Thr Phe Thr Ala Ser Phe Thr Arg Lys Val 
    450                 455                 460                 


Ile Pro Phe Phe Gly Leu Trp Gly Arg Gly Ser Ser Phe Ser Leu Ser 
465                 470                 475                 480 


Ser 
    


<210>  1404
<211>  3033
<212>  DNA
<213>  Homosapiens

<400>  1404
gagtgtgtga cccagccctt cccccgtggc caagcagaga gagtggcctt gaggaagcca     60

tagcagcagg accagcatgg cctctgctgc ctctgtgacc agcctggcag atgaagtcaa    120

ctgccccatc tgtcagggta ccctgaggga gccggtcact atcgactgcg gccacaactt    180

ctgccgggcc tgccttaccc gctactgtga gataccaggc ccagacctgg aggagtcccc    240

tacttgccca ctctgcaaag aacccttccg tcctgggagc ttccggccca actggcagct    300

ggctaacgtg gtggagaaca ttgagcgcct ccagctggtg tccacactgg gtttgggaga    360

ggaggatgtc tgccaagagc acggagggaa gatctacttc ttctgtgagg atgatgagat    420

gcagttgtgc gtggtgtgcc gggaggctgg ggagcacgct acccacacca tgcgcttcct    480

ggaggatgca gcggctccct atagggaaca aatccataag tgtcttaaat gtctaagaaa    540

agagagagag gagattcaag aaatccagtc aagaaaaaat aaaaggatgc aagtcctcct    600

gactcaggtg tccaccaaga gacaacaggt gatttctgag ttcgcacacc tgaggaagtt    660

tctagaggaa cagcagagca tcctcttagc acaattggag agccaggatg gggacatctt    720

gaggcaacgg gatgaatttg atttgctggt tgctggggag atctgccggt ttagtgctct    780

tattgaagaa ctggaggaga agaatgagag gccagcaagg gagctcctga cggacatcag    840

aagcactcta ataagatgtg aaaccagaaa gtgccggaaa ccggtggctg tgtcgccaga    900

gctgggccag aggattcggg actttcccca gcaggccctc ccgctgcaga gggagatgaa    960

gatgtttctg gaaaaactat gctttgagtt ggactatgag ccagctcaca tttctctaga   1020

ccctcagact tcccacccca agctcctctt gtccgaggac caccagcgag ctcagttctc   1080

ctacaaatgg cagaactcac cagacaaccc ccagcgtttt gaccgggcca cctgtgttct   1140

ggcccacact ggcatcacag gggggagaca cacgtgggtg tggatggcca gggtacctgg   1200

ggactcaggc ggctgccagt tctgctcacc accatccgtg cttggcacag aagtagctgc   1260

atagaaagag cactggattt gaagtcagaa gacctgggtt cttgaaccag cctgtcaacc   1320

agttgtatga ctttaaacaa ggcatctcac ctcttttcat cttgttttct tccaataatg   1380

ttagagttca tgtaatcaca ttctctagaa ccatttagtt tgtgttaact atgaaccaag   1440

cagtgtggtg gccactggtg acttgaaaat atagagaaaa aaaaaacctg ctctatatct   1500

gaaagagctc ttgggaagac agagaaacat aaagaggaaa ttacagcaca gtgtggtggg   1560

tgttacggga agtccaaccc cagcattatg ggagttcagg ggaaggggca tagcccagcc   1620

tggaaggaga gggtgagtgg gggatggctt tctgaaaagg gtggtctaaa ggatgcctat   1680

ggtcaatagg gaaaagaggg gaagaagcat cttaagaaga ggaaacagca gagaactggc   1740

tggatgacct gtgactctgg agcactgggt tgtctccatt gtcattatgg gcagatgtgt   1800

gccatcccca gccgacgcca ctcactgcct ccttcctcct ggtgttgcca cttctgggtg   1860

agattaaggt gcagggcctg ggggcaggag gacataaggt atagccataa atcataaccc   1920

agggaccaca ctcaacccta gggaaattgt cttcctgatc agttgattac catctgaggt   1980

caagaaatga gatagtggga gcaaatgggt cacaaatagc tcagctgtgg gctcagaaac   2040

tgctaggtaa aagaattcca gaaggaggcc agggcataag ttggatgacc tatgaacttt   2100

agtctaaaga attgagacta ccgtaattga gactactgta gtgacatctg agaaatggga   2160

tggaagagtg accatgtttt attttcttgt tcttgtcact attgtatttt attttgcata   2220

atcatgccct tcactgacag tctccttaac atcatctgtt tactctgctc agtgtaaact   2280

acaatgctct gtcatctccc tactgggtct cctgggagga ggggagccat ccagggtgca   2340

aactcaaagg cagagggcac agcgtgctta ggcccaagct tagaattcaa ttgagaagtt   2400

ctgttgttca tccttacctc agcaggtaga aaagaggtgg agatcagaag ccagggatta   2460

gagattgaat tgctttccct gggagtgtgc agtatctcat taaaatgttg tatattcaaa   2520

aaaatacaga cacacacaag tgcctatata atgataaaac atatccaaag cacccaaacc   2580

tgtgattcca gaaaagtaga tcctattttt gtttattttt attggcttta gctgtgtctt   2640

ttgaaaggac tattatcctc taaaatgtat gtgtatgaag atcctggctt gcagctcggg   2700

agctttacac accttgtgtc actttatctt ggtaacgagc caagatcatg caaccagttc   2760

atccatgtct gacccaagag ctcttaactg ctatgctgca ctgcctcatt cagagataga   2820

tgcctgcatg ggtcctggcg attattttaa tgctggctac acccccacag gtgacttgga   2880

ttcagaaata caatttatat ttcttctttt taaattgttt tattttattt ttcttttaat   2940

agttatatgt cagtgagaac aatttatatg tcttacactg agaaataaaa ctgctcataa   3000

gtgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                3033


<210>  1405
<211>  395
<212>  PRT
<213>  Homosapiens

<400>  1405

Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Gly Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Lys Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Trp Met Ala Arg Val Pro Gly Asp Ser Gly Gly Cys Gln Phe Cys Ser 
    370                 375                 380                 


Pro Pro Ser Val Leu Gly Thr Glu Val Ala Ala 
385                 390                 395 


<210>  1406
<211>  2255
<212>  DNA
<213>  Homosapiens

<400>  1406
gatgtgggca cgcctcagag ccagaagttt atggctccca cctgctcaat ctgacaggaa     60

gcttctgctc cccagttctc cccagccact gtggtctaca gattccagga aacccatccc    120

cctgtgacct cagggtgtgc tctgttctcc accctaggga ccagaaggag ccaggagtaa    180

agaactggct tacttggccg ccactgggaa attctgggta attcgagacg ccctggaatt    240

tggacccact ccgctgatag gtggtgggca gggttctagg gaacacaaga ggcggagcca    300

ggtggcttcc ctgtgctggc attcttggct ctctctctct ctctttctct ctctctgtct    360

ctctctctct ctctgtctct cagccttgaa gccgtttccc tctgcgattc atgtaagtgt    420

gactcgattt cagggaaagg gaactcgcgt gggctgagga gaccggagtg gacgggctgg    480

ggaaggcacc gtgatgcccg caaccccgtc cctgaaggtg gtccatgagc tgcctgcctg    540

taccctctgt gcggggccgc tggaggatgc ggtgaccgtt ccctgtggac acaccttctg    600

ccggctctgc ctccccgcgc tctcccagat gggggcccaa tcctcgggca agatcctgct    660

ctgcccgctc tgccaagagg aggagcaggc agagactccc atggcccctg tgcccctggg    720

cccgctggga gaaacttact gcgaggagca cggcgagaag atctacttct tctgcgagaa    780

cgatgccgag ttcctctgtg tgttctgcag ggagggtccc acgcaccagg cgcacaccgt    840

ggggttcctg gacgaggcca ttcagcccta ccgggatcgt ctcaggagtc gactggaagc    900

tctgagcacg gagagagatg agattgagga tgtaaagtgt caagaagacc agaagcttca    960

agtgctgctg actcagatcg aaagcaagaa gcatcaggtg gaaacagctt ttgagaggct   1020

gcagcaggag ctggagcagc agcgatgtct cctgctggcc aggctgaggg agctggagca   1080

gcagatttgg aaggagaggg atgaatatat cacaaaggtc tctgaggaag tcacccggct   1140

tggagcccag gtcaaggagc tggaggagaa gtgtcagcag ccagcaagtg agcttctaca   1200

agatgtcaga gtcaaccaga gcaggtgtga gatgaagact tttgtgagtc ctgaggccat   1260

ttctcctgac cttgtcaaga agatccgtga tttccacagg aaaatactca ccctcccaga   1320

gatgatgagg atgttctcag aaaacttggc gcatcatctg gaaatagatt caggggtcat   1380

cactctggac cctcagaccg ccagccggag cctggttctc tcggaagaca ggaagtcagt   1440

gaggtacacc cggcagaaga agagcctgcc agacagcccc ctgcgcttcg acggcctccc   1500

ggcggttctg ggcttcccgg gcttctcctc cgggcgccac cgctggcagg ttgacctgca   1560

gctgggcgac ggcggcggct gcacggtggg ggtggccggg gagggggtga ggaggaaggg   1620

agagatggga ctcagcgccg aggacggcgt ctgggccgtg atcatctcgc accagcagtg   1680

ctgggccagc acctccccgg gcaccgacct gccgctgagc gagatcccgc gcggcgtgag   1740

agtcgccctg gactacgagg cggggcaggt gaccctccac aacgcccaga cccaggagcc   1800

catcttcacc ttcactgcct ctttctccgg caaagtcttc cctttctttg ccgtctggaa   1860

aaaaggttcc tgccttacgc tgaaaggctg aagtggggcg cgcgaagggc ggcgaagcgg   1920

agacggcggc tctccgggat ccagctccgc ccctggccag tgtgcggccc gggggctccc   1980

tgtgcccgcg tgaggcgaga gaacagggga cttgagtctc gaacagcggt tgtttttact   2040

ttatttatct taggccctca gctccctgac gtcctgagcc tccctgtgac gctctggcct   2100

tctctgcacc tcagagtgca gaaccacaga cggcttcggc tgtgcctagg gcaacagcca   2160

acctaggagc cagcgggctt tcggggaaaa aaaagaaaaa gacatctaaa ataaaatgtt   2220

taaactgttt caaaataaaa aaaaaaaaaa aaaaa                              2255


<210>  1407
<211>  465
<212>  PRT
<213>  Homosapiens

<400>  1407

Met Pro Ala Thr Pro Ser Leu Lys Val Val His Glu Leu Pro Ala Cys 
1               5                   10                  15      


Thr Leu Cys Ala Gly Pro Leu Glu Asp Ala Val Thr Val Pro Cys Gly 
            20                  25                  30          


His Thr Phe Cys Arg Leu Cys Leu Pro Ala Leu Ser Gln Met Gly Ala 
        35                  40                  45              


Gln Ser Ser Gly Lys Ile Leu Leu Cys Pro Leu Cys Gln Glu Glu Glu 
    50                  55                  60                  


Gln Ala Glu Thr Pro Met Ala Pro Val Pro Leu Gly Pro Leu Gly Glu 
65                  70                  75                  80  


Thr Tyr Cys Glu Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asn 
                85                  90                  95      


Asp Ala Glu Phe Leu Cys Val Phe Cys Arg Glu Gly Pro Thr His Gln 
            100                 105                 110         


Ala His Thr Val Gly Phe Leu Asp Glu Ala Ile Gln Pro Tyr Arg Asp 
        115                 120                 125             


Arg Leu Arg Ser Arg Leu Glu Ala Leu Ser Thr Glu Arg Asp Glu Ile 
    130                 135                 140                 


Glu Asp Val Lys Cys Gln Glu Asp Gln Lys Leu Gln Val Leu Leu Thr 
145                 150                 155                 160 


Gln Ile Glu Ser Lys Lys His Gln Val Glu Thr Ala Phe Glu Arg Leu 
                165                 170                 175     


Gln Gln Glu Leu Glu Gln Gln Arg Cys Leu Leu Leu Ala Arg Leu Arg 
            180                 185                 190         


Glu Leu Glu Gln Gln Ile Trp Lys Glu Arg Asp Glu Tyr Ile Thr Lys 
        195                 200                 205             


Val Ser Glu Glu Val Thr Arg Leu Gly Ala Gln Val Lys Glu Leu Glu 
    210                 215                 220                 


Glu Lys Cys Gln Gln Pro Ala Ser Glu Leu Leu Gln Asp Val Arg Val 
225                 230                 235                 240 


Asn Gln Ser Arg Cys Glu Met Lys Thr Phe Val Ser Pro Glu Ala Ile 
                245                 250                 255     


Ser Pro Asp Leu Val Lys Lys Ile Arg Asp Phe His Arg Lys Ile Leu 
            260                 265                 270         


Thr Leu Pro Glu Met Met Arg Met Phe Ser Glu Asn Leu Ala His His 
        275                 280                 285             


Leu Glu Ile Asp Ser Gly Val Ile Thr Leu Asp Pro Gln Thr Ala Ser 
    290                 295                 300                 


Arg Ser Leu Val Leu Ser Glu Asp Arg Lys Ser Val Arg Tyr Thr Arg 
305                 310                 315                 320 


Gln Lys Lys Ser Leu Pro Asp Ser Pro Leu Arg Phe Asp Gly Leu Pro 
                325                 330                 335     


Ala Val Leu Gly Phe Pro Gly Phe Ser Ser Gly Arg His Arg Trp Gln 
            340                 345                 350         


Val Asp Leu Gln Leu Gly Asp Gly Gly Gly Cys Thr Val Gly Val Ala 
        355                 360                 365             


Gly Glu Gly Val Arg Arg Lys Gly Glu Met Gly Leu Ser Ala Glu Asp 
    370                 375                 380                 


Gly Val Trp Ala Val Ile Ile Ser His Gln Gln Cys Trp Ala Ser Thr 
385                 390                 395                 400 


Ser Pro Gly Thr Asp Leu Pro Leu Ser Glu Ile Pro Arg Gly Val Arg 
                405                 410                 415     


Val Ala Leu Asp Tyr Glu Ala Gly Gln Val Thr Leu His Asn Ala Gln 
            420                 425                 430         


Thr Gln Glu Pro Ile Phe Thr Phe Thr Ala Ser Phe Ser Gly Lys Val 
        435                 440                 445             


Phe Pro Phe Phe Ala Val Trp Lys Lys Gly Ser Cys Leu Thr Leu Lys 
    450                 455                 460                 


Gly 
465 


<210>  1408
<211>  454
<212>  DNA
<213>  Homosapiens

<400>  1408
atgcccgcaa ccccgtccct gaaggtggtc catgagctgc ctgcctgtac cctctgtgcg     60

gggccgctgg aggatgcggt gaccgttccc tgtggacaca ccttctgccg gctctgcctc    120

cccgcgctct cccagatggg ggcccaatcc tcgggcaaga tcctgctctg cccgctctgc    180

caagaggagg agcaggcaga gactcccatg gcccctgtgc ccctgggccc gctgggagaa    240

acttactgcg aggagcacgg cgagaagatc tacttcttct gcgagaacga tgccgagttc    300

ctctgtacct cagagtgcag aaccacagac ggcttcggct gtgcctaggg caacagccaa    360

cctaggagcc agcgggcttt cggggaaaaa aaagaaaaag acatctaaaa taaaatgttt    420

aaactgtttc aaaataaaaa aaaaaaaaaa aaaa                                454


<210>  1409
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  1409

Met Pro Ala Thr Pro Ser Leu Lys Val Val His Glu Leu Pro Ala Cys 
1               5                   10                  15      


Thr Leu Cys Ala Gly Pro Leu Glu Asp Ala Val Thr Val Pro Cys Gly 
            20                  25                  30          


His Thr Phe Cys Arg Leu Cys Leu Pro Ala Leu Ser Gln Met Gly Ala 
        35                  40                  45              


Gln Ser Ser Gly Lys Ile Leu Leu Cys Pro Leu Cys Gln Glu Glu Glu 
    50                  55                  60                  


Gln Ala Glu Thr Pro Met Ala Pro Val Pro Leu Gly Pro Leu Gly Glu 
65                  70                  75                  80  


Thr Tyr Cys Glu Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asn 
                85                  90                  95      


Asp Ala Glu Phe Leu Cys Thr Ser Glu Cys Arg Thr Thr Asp Gly Phe 
            100                 105                 110         


Gly Cys Ala 
        115 


<210>  1410
<211>  3499
<212>  DNA
<213>  Homosapiens

<400>  1410
cgggacccgg aacagaccgc cgtgagagag gaggggtgcc ggccgggatt cgcggcccgg     60

agctcgggac cggagtcagg aatggagaga agggtaatgg ttttacctct tattgtggaa    120

acctgttgag atcacagaga atatactgac ggcataaaag ggcagaacca tagcagggtg    180

cggttgcttc attccagcct cgcagtcacc tctgtgccct gctggttgtc ttcccagcgc    240

tgctgtagtt gccttccatg gatctatagg agagcaagtc ctccaggagc tggtggtgtc    300

tgtcgattga ctgagtgctg gagctggcag ccctgtgcag gctgccacct ttgccccttt    360

actgtgcttg ctcctgactc tatgtcgcgt ctccaaggag aagaagtcct caccagtgaa    420

cggagacctc tctgaactaa ggataccatg gccacgtcag ccccactacg gagcctggaa    480

gaggaggtga cctgctccat ctgtcttgat tacctgcggg accctgtgac cattgactgt    540

ggccacgtct tctgccgcag ctgcaccaca gacgtccgcc ccatctcagg gagccgcccc    600

gtctgcccac tctgcaagaa gccttttaag aaggagaaca tccgacccgt gtggcaactg    660

gccagcctgg tggagaacat tgagcggctg aaggtggaca agggcaggca gccgggagag    720

gtgacccggg agcagcagga tgcaaagttg tgcgagcgac accgagagaa gctgcactac    780

tactgtgagg acgacgggaa gctgctgtgc gtgatgtgcc gggagtcccg ggagcacagg    840

ccccacacgg ccgtcctcat ggagaaggcc gcccagcccc acagggaaaa aatcctgaac    900

cacctgagta ccctaaggag ggacagagac aaaattcagg gcttccaggc aaagggagaa    960

gctgatatcc tggccgcgct gaagaagctc caggaccaga ggcagtacat tgtggctgag   1020

tttgagcagg gtcatcagtt cctgagggag cgggaggaac acctgctgga acagctggcg   1080

aagctggagc aggagctcac ggagggcagg gagaagttca agagccgggg cgtcggggag   1140

cttgcccggc tggccctggt catctccgaa ctggagggca aggcgcagca gccagctgca   1200

gagctcatgc aggacacgag agacttccta aacaggtatc cacggaagaa gttctgggtt   1260

gggaaaccca ttgctcgagt ggttaaaaaa aagaccggag aattctcaga taaactcctc   1320

tctctgcaac gaggcctgag ggaattccag gggaagctgc tgagagactt ggaatataag   1380

acagtgagcg tcaccctgga cccacagtcg gccagtgggt acctgcagct gtcagaggac   1440

tggaagtgcg tgacctacac cagcctgtac aagagtgcct acctgcaccc ccagcagttt   1500

gactgtgagc ctggggtgct aggcagcaag ggcttcacct ggggcaaggt ctactgggaa   1560

gtggaagtgg agagggaggg ctggtctgag gatgaagaag agggggatga ggaggaagag   1620

ggagaagagg aggaggagga agaggaggcc ggctatgggg atggatatga cgactgggaa   1680

acggacgaag atgaggaatc gttgggcgat gaagaggaag aagaggagga ggaagaggag   1740

gaagttctgg aaagctgcat ggtgggggtg gctagagact ctgtgaagag gaagggagac   1800

ctctccctgc ggccagagga tggcgtgtgg gcgctgcgcc tctcctcctc cggcatctgg   1860

gccaacacca gccccgaggc tgagcttttc ccagcactgc ggccccggag agtgggcatc   1920

gccctggatt atgaaggggg caccgtgact ttcaccaacg cagagtcaca ggaactcatc   1980

tacaccttca ctgccacctt cacccggcgc ctggtcccct tcctgtggct caagtggcca   2040

ggaacacgcc tcctgctaag accctgagcc ctgacatctg cccccagccc caaccctcag   2100

atgcttcact tctttggaat tccaggactc tcaatggggg gacgggatgc ctggcctaag   2160

cacctggagc aggggacccc atatccactg gtagccacct ccccattgct gtggccccct   2220

gaaatctcac tcagtgctgt tgctccatct actgccctaa tggggctctt ttcccacctc   2280

ctgctggttt cccgagggaa cttctgaccc tggagtccat gagggctcct ttcctttttg   2340

accacgacct tggccccagc tctgcactct ctggaataag ggcccgatgc agcattttct   2400

tgcccagtgt ggcaagacct cagaaaaacc agtcaattac gcctaagatc attttgctgt   2460

ccttaaaccc cccaggttcc ttcttgcaca aatccactct gctgcccacc ttccctggca   2520

ttttaaacag acctacccca ccccaactca gagttaagca tacatggcaa tgctgaaaat   2580

aaacaaaatc cactgaggct tcccaggcca tttaaagcct ggagtaccag cgcatatcat   2640

ctcatggggt ccagagtgga gtccaggctt ctctgaaacc agggctgagc atatttccat   2700

agccaaggag gtgggactcc ctggagctat ctgtggtctt agggaaggat ccagacatac   2760

acggctttgg ggtacaagct gtgatcactg atcaataaat tatctctaga ttggtccttg   2820

tgaggggagt tttaagaatc cagaacatct tgctcttgat cagcacatcc aaaaacacca   2880

agacaaacat ccagtggagc agaacctctc ctgcctcggg agttctgacc gggttcccca   2940

gcagggtgtt aagcctctgt ctctggccct accagcatcc aggttccact ttcctaggag   3000

agagtggaga tgggaagaca gggaaaggaa ggcagcagga ggccacaagc ccaccaggtc   3060

ttcatgtcaa gagagggagt aacatgtctt ctcattgccc acggacccaa cctctgtcca   3120

ggtgcccctc atcatcacag tttaacacaa gctcccctgc tccagccaaa ttgatctccc   3180

agtcttgtcc ttacccattc caagtgctct gccagcccct gttcatccaa gttttaagtc   3240

ctccaccctg ttctaagaga ctgttccaac ggctctgggc ctcagtggtc acttgaccac   3300

cattgtctca gagctgccca ctttgtgtgt gtcacatgct gcctgagtca catgtacatc   3360

ttatttctgc ctctagtttt gtaagctcct ggagggcgga taacatctta tactactctt   3420

gtattctcat ggcacctagt gcagtgctgg gcacagagta ggtgctcaat aaagacttgt   3480

tgaatgaaaa aaaaaaaaa                                                3499


<210>  1411
<211>  539
<212>  PRT
<213>  Homosapiens

<400>  1411

Met Ala Thr Ser Ala Pro Leu Arg Ser Leu Glu Glu Glu Val Thr Cys 
1               5                   10                  15      


Ser Ile Cys Leu Asp Tyr Leu Arg Asp Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Val Phe Cys Arg Ser Cys Thr Thr Asp Val Arg Pro Ile Ser Gly 
        35                  40                  45              


Ser Arg Pro Val Cys Pro Leu Cys Lys Lys Pro Phe Lys Lys Glu Asn 
    50                  55                  60                  


Ile Arg Pro Val Trp Gln Leu Ala Ser Leu Val Glu Asn Ile Glu Arg 
65                  70                  75                  80  


Leu Lys Val Asp Lys Gly Arg Gln Pro Gly Glu Val Thr Arg Glu Gln 
                85                  90                  95      


Gln Asp Ala Lys Leu Cys Glu Arg His Arg Glu Lys Leu His Tyr Tyr 
            100                 105                 110         


Cys Glu Asp Asp Gly Lys Leu Leu Cys Val Met Cys Arg Glu Ser Arg 
        115                 120                 125             


Glu His Arg Pro His Thr Ala Val Leu Met Glu Lys Ala Ala Gln Pro 
    130                 135                 140                 


His Arg Glu Lys Ile Leu Asn His Leu Ser Thr Leu Arg Arg Asp Arg 
145                 150                 155                 160 


Asp Lys Ile Gln Gly Phe Gln Ala Lys Gly Glu Ala Asp Ile Leu Ala 
                165                 170                 175     


Ala Leu Lys Lys Leu Gln Asp Gln Arg Gln Tyr Ile Val Ala Glu Phe 
            180                 185                 190         


Glu Gln Gly His Gln Phe Leu Arg Glu Arg Glu Glu His Leu Leu Glu 
        195                 200                 205             


Gln Leu Ala Lys Leu Glu Gln Glu Leu Thr Glu Gly Arg Glu Lys Phe 
    210                 215                 220                 


Lys Ser Arg Gly Val Gly Glu Leu Ala Arg Leu Ala Leu Val Ile Ser 
225                 230                 235                 240 


Glu Leu Glu Gly Lys Ala Gln Gln Pro Ala Ala Glu Leu Met Gln Asp 
                245                 250                 255     


Thr Arg Asp Phe Leu Asn Arg Tyr Pro Arg Lys Lys Phe Trp Val Gly 
            260                 265                 270         


Lys Pro Ile Ala Arg Val Val Lys Lys Lys Thr Gly Glu Phe Ser Asp 
        275                 280                 285             


Lys Leu Leu Ser Leu Gln Arg Gly Leu Arg Glu Phe Gln Gly Lys Leu 
    290                 295                 300                 


Leu Arg Asp Leu Glu Tyr Lys Thr Val Ser Val Thr Leu Asp Pro Gln 
305                 310                 315                 320 


Ser Ala Ser Gly Tyr Leu Gln Leu Ser Glu Asp Trp Lys Cys Val Thr 
                325                 330                 335     


Tyr Thr Ser Leu Tyr Lys Ser Ala Tyr Leu His Pro Gln Gln Phe Asp 
            340                 345                 350         


Cys Glu Pro Gly Val Leu Gly Ser Lys Gly Phe Thr Trp Gly Lys Val 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Arg Glu Gly Trp Ser Glu Asp Glu Glu 
    370                 375                 380                 


Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Ala Gly Tyr Gly Asp Gly Tyr Asp Asp Trp Glu Thr Asp Glu Asp Glu 
                405                 410                 415     


Glu Ser Leu Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Val Leu Glu Ser Cys Met Val Gly Val Ala Arg Asp Ser Val Lys Arg 
        435                 440                 445             


Lys Gly Asp Leu Ser Leu Arg Pro Glu Asp Gly Val Trp Ala Leu Arg 
    450                 455                 460                 


Leu Ser Ser Ser Gly Ile Trp Ala Asn Thr Ser Pro Glu Ala Glu Leu 
465                 470                 475                 480 


Phe Pro Ala Leu Arg Pro Arg Arg Val Gly Ile Ala Leu Asp Tyr Glu 
                485                 490                 495     


Gly Gly Thr Val Thr Phe Thr Asn Ala Glu Ser Gln Glu Leu Ile Tyr 
            500                 505                 510         


Thr Phe Thr Ala Thr Phe Thr Arg Arg Leu Val Pro Phe Leu Trp Leu 
        515                 520                 525             


Lys Trp Pro Gly Thr Arg Leu Leu Leu Arg Pro 
    530                 535                 


<210>  1412
<211>  4587
<212>  DNA
<213>  Homosapiens

<400>  1412
gcactcagat tctccccaaa cgccaaggat gggggtcatg gctccccgaa ccctcctcct     60

gctgctcttg ggggccctgg ccctgaccga gacctgggcc gcgactccgt gagtccgagg    120

atggagcggc gggcgccgtg ggtggagcag gaggggctgg agtattggga ccaggagaca    180

cggaacgcca agggccacgc gcagatttac cgagtgaacc tgcggaccct gctccgctat    240

tacaaccaga gcgaggccgg tatgaacagt tcgcctacga tggcaaggat tacatcgccc    300

tgaacgagga cctgcactcc tggaccgccg cgaacacagc ggctcagatc tcccagcaca    360

agtgggaagc ggacaaatac tcagagcagg tcagggccta cctgagggca agtgcatgga    420

gtggctccgc agacacctgg agaacgggaa ggagacgctg cagcacgcgg atcccccaaa    480

ggcacatgtg acccagcacc ccatctctga ccatgaggcc accctgaggt gctgggccct    540

gggcctctac cctgcggaga tcacactgac ctggcagcag gatggggagg accagaccca    600

ggacacggag cttgtggaga ccaggcctgc aggggacgga accttccaga agtgggtggc    660

tgtagtggtg ccttccggag aggagcagag atacatgtgc catgtgcagc atgaggggct    720

gccagagccc ctcaccctga gatgggagcc gtcttctcag cccaccatcc ccatcgtggg    780

catcgttgct ggcctgtttc tccttggagc tgtggtcact ggagctgtgg ttgctgctgc    840

gatgtggagg aagaaaagct caggcagcaa ttgtgctcag tactctgatg catctcatga    900

tacttgtaaa gaggactatg cctgttcctg ttctggtgtc tgcgttctga tctctttctc    960

ccctgggtgt ccctcatctc tgacagcagc aggagtcatt tttcctgtca ttaaccccac   1020

aaggtggaag gcagcccctg cacacagaag tctgtggtat taagagatga attttcaagc   1080

ccgtgcagct tttaccctat ttccagggct ctttcttggg ttgtattttc tatcttttcc   1140

ccaacctttt taaaggaact agattctgaa attagcagag aagagggatg ccacaagttc   1200

tcatcttagg taactttcta gtggaactcc tcttctgctc agctctccta cccactctcc   1260

cttccctgag ttgtagtaat cctagcactg gctctaatgc aaactcatgg atctataaag   1320

caaagtctaa cttagattta tatttgtttg gaaattggga ttcatagtca aagattgttc   1380

tttcctaaga gggaaatata attgcatgct gcagtgtgca gagggttggt gtgaaggagg   1440

gatgcaggga ggaagggagg gaggacacac aagcagcact gctgggaaaa gcacaggcgg   1500

cctggatgtc agtgtgaggg gaccttatgc tgtcgttgct gcaaaaccgc atttggcctg   1560

aggctatgtt aataaagata ctgcctttag aataggaggt gctctacagt gatgattcat   1620

tcagccgaca tttgctgtct gccagacata tgacagaatg tttttgcatc tggggaaagt   1680

cattgaagta aaatcagaaa aatctctagc cttgtggagc atgtgttcca gtgggaagag   1740

gcagacggta catacactct aatatatgca gagtaaatga ggaaagtgtt agaaggtgat   1800

aagtgctgtg gaacaggtga tcagagtatg ggttgtggga cagagaaggt agctattgtg   1860

ccggggttgt cagcgtgggc cttgttggga aggtgacctt tgatgaaata tttgaaggac   1920

ataaaggaat ttgtcatgag ggtatctgga agaagttttt tctagggagt aggaaccttc   1980

agtgtcagtg taccagggca ggatcatgtc tgtgtgttct gggaagaaca cgggatcggg   2040

tatggctaga gcagagagtc actgagataa ggtcaggggt ttggtcagat catgtgggca   2100

tagggctcaa gtatgtggga aggattttga ttttgaatga gatagtttta agcagaataa   2160

agacatgcca caacttctct tttaaaagga tcactgtagc tgctctgctg agaacagaat   2220

ccaaaggccg gcgatgagca aggcaggtgg gagaactgta ggaaatgagt gcagtatttc   2280

aggctggaga tgtcggttac ttcaactggg gtgtgagcag tggaaatagt gggacgtgat   2340

tggattccta ctatttccaa tcactttata ccgcattttc taatggacta aatctggggt   2400

atgagaaaga agagtaaagg ataccaaaaa tgtcagactg tgactaaaaa gagttgccat   2460

cagctgagaa tgagaagact agcaggagca tatgagagga ggggacgtcg caggcagtca   2520

ctatgggaga cgtgggatct gagatgccgc tgagaaatac cagtgaggta gtcgggttgg   2580

cagttggaca gatgaatctg gagacattta ggagaaatag acttgggagg tgatgtcata   2640

taacagttat ttaaagcctt gagtctgaat gacgtctcca agggagtgat tggctgtaga   2700

agagaacagg aacaaggact gaacactagg cctctgttgc taaaggatct gatcagacaa   2760

cacacctaga tcagactgca cagtcctgac cccacatcta gaaggtacat agaccaggga   2820

gttctagact ttcctgtgga caggaatcac ctggacatca ccttaagtct aagctgatct   2880

ggaatcgaga atgagatttc ctacttatat aatgttgctg ttggcgctga tgctgctggt   2940

cttcagatcc cacttttggt agcaagaaca cagaccagga ttcctaggct atgcatcagc   3000

ctcgcctgtg aggcttgtta ataagcaatt cctgcactcc atgcgcaaca ttctgacaca   3060

ggggcatctg tggagaggcc tgagtattct acaacaagcc cacagcaaac ctggtgctca   3120

gccagatttg atatcactga gatcagtagt tggagaatgc ccaggatggg gaggggtctc   3180

agacccacat ttaagtgttg ctttattctg ggttttttat ttatttattt atttattttt   3240

aaggaggatg tgtttcttta attataagac aggatgctga gagataaatg tcattttctc   3300

tatcatgggg tatagccaga tggaagattg agaagtggct cacagctcag cagaatgaaa   3360

aaatatctga atgctgcttt ctgaaactac tctccagaat gatttcacac tcactccttg   3420

gagcaaacaa tgacttgcaa atttttctaa tttaaacata aaggagtgta catattggta   3480

ttagtattca ttttattttg gggaagggca ctgtattagt ccatagtccg ttttcacact   3540

gccgataaag acatacccaa cattgggaag aaaaagaggt ttaattggac ttacagttcc   3600

atttggctgg ggaggcctca gaatcatggt gggaggcgaa aggcacttct tacatggtgg   3660

tggcaagaga aaatgaggaa gaagcaaatg ccaaaacccc tgataaacac attggatctc   3720

aggagactta ttcattatca tgagaatagc atgggaaaga ctggccccca tgattcaatt   3780

acctccccct gggtccctcc cacaacatgt gggaattctg ggagatacaa ttcaagttga   3840

gatttgggtg gggacacagc caaaccacat tggacacaga accaggtttg aagctacaca   3900

gccaggaaca taatccacag ccaccctaat tcagatctct cataggaacc actgtccctg   3960

ctcctgagca cagatgctac tgcatatacc tctgataccc tgatggccga cactgggccc   4020

tgtggcaaag actgctatca ctgctgctcc tgagaactgc tccactactg ctcctcagcc   4080

atctttacca aaatgcagta tttactgtcc cagcctctct gtgtcatctc atcctgatta   4140

gaagcccaca tgtggttatc taaattgtgc agccaaagcc tcttgcagtg tttaactgca   4200

ataatgttgg ggaaagtgaa tttttctcct ttgtagaagg aggtagtccc tgccttctaa   4260

taagactctt caacatagga agagaattca gttgctggag gtagaggggt gagggatgga   4320

aaaagaatga caaatttcaa ttcctagaat catgttctga gactagaact ttatctagta   4380

cattgcaggc acctgggttt ggttgagtgt ataataaatg acatagttca acttattccc   4440

ttgacagttt gttttggggt ccagcttttg tctaccccag ttttcacaca cagatacgtg   4500

gagaagcatt gtgtgatggt aaaatgttta cttgaaagcc tttttcccta tctttgtctc   4560

ttgctaggat taaaaacccg tatctgt                                       4587


<210>  1413
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  1413

Met Glu Trp Leu Arg Arg His Leu Glu Asn Gly Lys Glu Thr Leu Gln 
1               5                   10                  15      


His Ala Asp Pro Pro Lys Ala His Val Thr Gln His Pro Ile Ser Asp 
            20                  25                  30          


His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Leu Tyr Pro Ala Glu 
        35                  40                  45              


Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Asp Gln Thr Gln Asp Thr 
    50                  55                  60                  


Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp 
65                  70                  75                  80  


Val Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Met Cys His 
                85                  90                  95      


Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Glu Pro 
            100                 105                 110         


Ser Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Phe 
        115                 120                 125             


Leu Leu Gly Ala Val Val Thr Gly Ala Val Val Ala Ala Ala Met Trp 
    130                 135                 140                 


Arg Lys Lys Ser Ser Gly Ser Asn Cys Ala Gln Tyr Ser Asp Ala Ser 
145                 150                 155                 160 


His Asp Thr Cys Lys Glu Asp Tyr Ala Cys Ser Cys Ser Gly Val Cys 
                165                 170                 175     


Val Leu Ile Ser Phe Ser Pro Gly Cys Pro Ser Ser Leu Thr Ala Ala 
            180                 185                 190         


Gly Val Ile Phe Pro Val Ile Asn Pro Thr Arg Trp Lys Ala Ala Pro 
        195                 200                 205             


Ala His Arg Ser Leu Trp Tyr 
    210                 215 


<210>  1414
<211>  3635
<212>  DNA
<213>  Homosapiens

<400>  1414
agcgtcatag cggcgggcat cccatctgca cgtcacacct ctttctcacc tggacacgca     60

tcccttccta ccctgccagc cacgacgttt cctctttccc ctctccaatg cccagcccca    120

gatctggcgg aagaagatgg agaacggggg tgggacagag ttgtggacaa cctctcagga    180

gagggtcgca aggtgggacc ctgaacagtg gtagaaacaa aatgagattg tccctgaagt    240

ttgcccttca gctgagacac aaggagtaga ggaagaggaa ggactaacgc agaggcactc    300

aaggtctcac tatgactgta gttgagagtc ctctcccttc ttccctaacc ctttccccat    360

ttctctcacc acttctttgc cagtctagat ccgtcctggt gccttactgt gcatacagtt    420

ctactcgtct cagattcctt tcttgtctgt tagaaacgta tgtcaaacga ggatacagtg    480

tctggaacta ttggttctaa gatataagtg gaatgagcct ggatcaggag aagtatgctg    540

agctagagtt gaaggaagct tctctttcta acaagagaaa gcagagttaa attatggcag    600

agacaagtct gttagaggct ggggcctctg cagcctctac agctgcggct ttggagaact    660

tacaggtgga ggcgagctgc tctgtgtgcc tggagtatct gaaggaacct gtcatcattg    720

agtgtgggca caacttctgc aaagcttgca tcacccgctg gtgggaggac ctagagaggg    780

acttcccttg tcctgtctgt cgaaagacat cccgctaccg cagtctccga cctaatcggc    840

aactaggcag tatggtggaa attgccaagc agctccaggc cgtcaagcgg aagatccggg    900

atgagagcct ctgcccccaa caccatgagg ccctcagcct tttctgttat gaggaccagg    960

aggctgtatg cttgatatgt gcaatttccc acacccaccg ggctcacacc gttgtgccac   1020

tggacgatgc tacacaggag tacaaggaaa aactgcagaa gtgtctggag cccctggaac   1080

agaagctgca ggagatcact cgctgcaagt cctctgagga gaagaagcct ggtgagctca   1140

agagactagt ggaaagtcgc cgacagcaga tcttgaggga gtttgaagag cttcataggc   1200

ggctggatga agagcagcag gtgttgcttt cacgactgga agaagaggaa caggacattc   1260

tgcagcgact ccgagaaaat gctgctcacc ttggggacaa gcgccgggac ctggcccact   1320

tggctgccga ggtggagggc aagtgcttac agtcaggctt cgagatgctt aaggatgtca   1380

aaagtaccct ggaaaagaat attcctagaa agttcggagg ctcactctca acgatctgtc   1440

cacgggatca taaggctctc cttggattag taaaagaaat caacagatgt gaaaaggtga   1500

agaccatgga ggtgacttca gtatccatag agctggaaaa gaacttcagc aattttcccc   1560

gacagtactt tgccctaagg aaaatcctta aacagctaat tgcggatgtg accctggacc   1620

ctgagacagc tcatcctaac ctagtcctgt cagaggatcg taagagcgtc aagttcgtgg   1680

agacaagact ccgggatctc cctgacacac caaggcgttt caccttctac ccttgcgtcc   1740

tggctactga gggtttcacc tcaggtcgac actactggga ggtggaggtg ggcgacaaga   1800

cccactgggc agtgggtgta tgccgggact ccgtgagccg aaagggcgag ttgactccac   1860

tccctgagac tggctactgg cgggtgcggc tatggaatgg ggacaaatat gcagccacca   1920

ccacaccttt tacccctttg cacatcaagg tgaaacccaa gcgggtaggc atattcctag   1980

actatgaggc cggcacactg tctttctaca atgtcacaga ccgctctcat atctacacct   2040

tcactgatac ttttactgag aaactttggc ccctcttcta cccaggcatc cgggctggac   2100

ggaagaatgc tgcaccactt accatcaggc ccccaacaga ttgggagtga caggttggga   2160

tgtgggaatg actggggtga ggcagggtca agtgctacgg gcctccttcc cgtgtcctgc   2220

tggaacgtct tcgtgtccac ctgggtccag tcctgaatca tcttggagaa acaccttggt   2280

ttctaggatg gttttgtgtg gagggggagg taggactggg ctggatgaga gagcacagct   2340

gtgacttcct cctaactgtc agggtgggga gctggttccc agaggattgt ctaccctgaa   2400

gtccatcagg ttttctgttg cacaaggacg ggtcaggaag gaaggagagg cttttccaga   2460

aacaaaaaat ctgtgagggt ctgacttgct caaaccagag gaggaaacag aaacccctgc   2520

acatcttttt agggggttct ttgacccagg atagtcttgc ttcttgaggt agatcacagg   2580

ggtctgtgta cctctgaatt catgagagat gaatgacaga tgctctcatg ggtctagata   2640

ttgaggagtt tttctgaggg cagagattgg acatcaacaa ggctagaagg gtcagggaag   2700

tgggctaaag gaacagattc ctagagatta atgaagagga gggaggtttc tttggtcttc   2760

tattccaagg gtaaggttgc gattatgggt aagattggcc agaggtagga atgtggggag   2820

aaggagaggc tgaaaagaaa gcagaggaga acccaggtcc ctgcctcagc cttcagcaga   2880

gttggcttat tgcctgcctc tataccaata agtcagtcac cttgctcctc tccagaggca   2940

aagtggaaga gatcctgcaa gacacatcta tcctttcaca gtgttcccaa gggaacttgg   3000

aaaggagagt caggtattag aggaaagaga agggtatttg tatacaaagc cctggcctta   3060

aagaatgtta cttagtagct actcccaaat tgtcagcctt cttacctggc caaggtgtcc   3120

aagccagaaa ggaaaaaagg ttatggagtc tttctcaccc taaggacagg gtggaagagg   3180

gtggtatata gggaagggcc agataggcaa cttcatttgg cttgtgtgca tctggcctgg   3240

aactggtgtt aagccaggct tttgcttgtt tgttgccatc cctcaccctt tgccatttcc   3300

cttttcagag aatgtaaatg attttcatgt taggccaaaa taaacaactt atagggtaca   3360

tatgttgtca taaaaggtaa aagtgatgca tgccaaacca aactaaacca atttggatta   3420

tctgctattc gggtaatctt cacagaaatg actgagagaa gaatctgcag tttactgagg   3480

gcatttcagt tcctcctacc acctcaacag gactttgtcc agactctcct cctcttacct   3540

ttgtgccttg actgtggttc tttgtggcaa gatactttgg ttggttaaaa taatatggaa   3600

caaaggatcc actgaagtga aaaaaaaaaa aaaaa                              3635


<210>  1415
<211>  518
<212>  PRT
<213>  Homosapiens

<400>  1415

Met Ala Glu Thr Ser Leu Leu Glu Ala Gly Ala Ser Ala Ala Ser Thr 
1               5                   10                  15      


Ala Ala Ala Leu Glu Asn Leu Gln Val Glu Ala Ser Cys Ser Val Cys 
            20                  25                  30          


Leu Glu Tyr Leu Lys Glu Pro Val Ile Ile Glu Cys Gly His Asn Phe 
        35                  40                  45              


Cys Lys Ala Cys Ile Thr Arg Trp Trp Glu Asp Leu Glu Arg Asp Phe 
    50                  55                  60                  


Pro Cys Pro Val Cys Arg Lys Thr Ser Arg Tyr Arg Ser Leu Arg Pro 
65                  70                  75                  80  


Asn Arg Gln Leu Gly Ser Met Val Glu Ile Ala Lys Gln Leu Gln Ala 
                85                  90                  95      


Val Lys Arg Lys Ile Arg Asp Glu Ser Leu Cys Pro Gln His His Glu 
            100                 105                 110         


Ala Leu Ser Leu Phe Cys Tyr Glu Asp Gln Glu Ala Val Cys Leu Ile 
        115                 120                 125             


Cys Ala Ile Ser His Thr His Arg Ala His Thr Val Val Pro Leu Asp 
    130                 135                 140                 


Asp Ala Thr Gln Glu Tyr Lys Glu Lys Leu Gln Lys Cys Leu Glu Pro 
145                 150                 155                 160 


Leu Glu Gln Lys Leu Gln Glu Ile Thr Arg Cys Lys Ser Ser Glu Glu 
                165                 170                 175     


Lys Lys Pro Gly Glu Leu Lys Arg Leu Val Glu Ser Arg Arg Gln Gln 
            180                 185                 190         


Ile Leu Arg Glu Phe Glu Glu Leu His Arg Arg Leu Asp Glu Glu Gln 
        195                 200                 205             


Gln Val Leu Leu Ser Arg Leu Glu Glu Glu Glu Gln Asp Ile Leu Gln 
    210                 215                 220                 


Arg Leu Arg Glu Asn Ala Ala His Leu Gly Asp Lys Arg Arg Asp Leu 
225                 230                 235                 240 


Ala His Leu Ala Ala Glu Val Glu Gly Lys Cys Leu Gln Ser Gly Phe 
                245                 250                 255     


Glu Met Leu Lys Asp Val Lys Ser Thr Leu Glu Lys Asn Ile Pro Arg 
            260                 265                 270         


Lys Phe Gly Gly Ser Leu Ser Thr Ile Cys Pro Arg Asp His Lys Ala 
        275                 280                 285             


Leu Leu Gly Leu Val Lys Glu Ile Asn Arg Cys Glu Lys Val Lys Thr 
    290                 295                 300                 


Met Glu Val Thr Ser Val Ser Ile Glu Leu Glu Lys Asn Phe Ser Asn 
305                 310                 315                 320 


Phe Pro Arg Gln Tyr Phe Ala Leu Arg Lys Ile Leu Lys Gln Leu Ile 
                325                 330                 335     


Ala Asp Val Thr Leu Asp Pro Glu Thr Ala His Pro Asn Leu Val Leu 
            340                 345                 350         


Ser Glu Asp Arg Lys Ser Val Lys Phe Val Glu Thr Arg Leu Arg Asp 
        355                 360                 365             


Leu Pro Asp Thr Pro Arg Arg Phe Thr Phe Tyr Pro Cys Val Leu Ala 
    370                 375                 380                 


Thr Glu Gly Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly 
385                 390                 395                 400 


Asp Lys Thr His Trp Ala Val Gly Val Cys Arg Asp Ser Val Ser Arg 
                405                 410                 415     


Lys Gly Glu Leu Thr Pro Leu Pro Glu Thr Gly Tyr Trp Arg Val Arg 
            420                 425                 430         


Leu Trp Asn Gly Asp Lys Tyr Ala Ala Thr Thr Thr Pro Phe Thr Pro 
        435                 440                 445             


Leu His Ile Lys Val Lys Pro Lys Arg Val Gly Ile Phe Leu Asp Tyr 
    450                 455                 460                 


Glu Ala Gly Thr Leu Ser Phe Tyr Asn Val Thr Asp Arg Ser His Ile 
465                 470                 475                 480 


Tyr Thr Phe Thr Asp Thr Phe Thr Glu Lys Leu Trp Pro Leu Phe Tyr 
                485                 490                 495     


Pro Gly Ile Arg Ala Gly Arg Lys Asn Ala Ala Pro Leu Thr Ile Arg 
            500                 505                 510         


Pro Pro Thr Asp Trp Glu 
        515             


<210>  1416
<211>  3545
<212>  DNA
<213>  Homosapiens

<400>  1416
agcgtcatag cggcgggcat cccatctgca cgtcacacct ctttctcacc tggacacgca     60

tcccttccta ccctgccagc cacgacgttt cctctttccc ctctccaatg cccagcccca    120

gatctggcgg aagaagatgg agaacggggg tgggacagag ttgtggacaa cctctcagga    180

gagggtcgca aggtgggacc ctgaacagtg gtagaaacaa aatgagattg tccctgaagt    240

ttgcccttca gctgagacac aaggagtaga ggaagaggaa ggactaacgc agaggcactc    300

aaggtctcac tatgactgta gttgagagtc ctctcccttc ttccctaacc ctttccccat    360

ttctctcacc acttctttgc cagtctagat ccgtcctggt gccttactgt gcatacagtt    420

ctactcgtct cagattcctt tcttgtctgt tagaaacgta tgtcaaacga ggatacagtg    480

tctggaacta ttggttctaa gatataagtg gaatgagcct ggatcaggag aagtatgctg    540

agctagagtt gaaggaagct tctctttcta acaagagaaa gcagagttaa attatggcag    600

agacaagtct gttagaggct ggggcctctg cagcctctac agctgcggct ttggagaact    660

tacaggtgga ggcgagctgc tctgtgtgcc tggagtatct gaaggaacct gtcatcattg    720

agtgtgggca caacttctgc aaagcttgca tcacccgctg gtgggaggac ctagagaggg    780

acttcccttg tcctgtctgt cgaaagacat cccgctaccg cagtctccga cctaatcggc    840

aactaggcag tatggtggaa attgccaagc agctccaggc cgtcaagcgg aagatccggg    900

atgagagcct ctgcccccaa caccatgagg ccctcagcct tttctgttat gaggaccagg    960

aggctgtatg cttgatatgt gcaatttccc acacccaccg ggctcacacc gttgtgccac   1020

tggacgatgc tacacaggag tacaaggaaa aactgcagaa gtgtctggag cccctggaac   1080

agaagctgca ggagatcact cgctgcaagt cctctgagga gaagaagcct ggtgagctca   1140

agagactagt ggaaagtcgc cgacagcaga tcttgaggga gtttgaagag cttcataggc   1200

ggctggatga agagcagcag gtgttgcttt cacgactgga agaagaggaa caggacattc   1260

tgcagcgact ccgagaaaat gctgctcacc ttggggacaa gcgccgggac ctggcccact   1320

tggctgccga ggtggagggc aagtgcttac agtcaggctt cgagatgctt aaggatgtca   1380

aaagtaccct ggaaaaatgt gaaaaggtga agaccatgga ggtgacttca gtatccatag   1440

agctggaaaa gaacttcagc aattttcccc gacagtactt tgccctaagg aaaatcctta   1500

aacagctaat tgcggatgtg accctggacc ctgagacagc tcatcctaac ctagtcctgt   1560

cagaggatcg taagagcgtc aagttcgtgg agacaagact ccgggatctc cctgacacac   1620

caaggcgttt caccttctac ccttgcgtcc tggctactga gggtttcacc tcaggtcgac   1680

actactggga ggtggaggtg ggcgacaaga cccactgggc agtgggtgta tgccgggact   1740

ccgtgagccg aaagggcgag ttgactccac tccctgagac tggctactgg cgggtgcggc   1800

tatggaatgg ggacaaatat gcagccacca ccacaccttt tacccctttg cacatcaagg   1860

tgaaacccaa gcgggtaggc atattcctag actatgaggc cggcacactg tctttctaca   1920

atgtcacaga ccgctctcat atctacacct tcactgatac ttttactgag aaactttggc   1980

ccctcttcta cccaggcatc cgggctggac ggaagaatgc tgcaccactt accatcaggc   2040

ccccaacaga ttgggagtga caggttggga tgtgggaatg actggggtga ggcagggtca   2100

agtgctacgg gcctccttcc cgtgtcctgc tggaacgtct tcgtgtccac ctgggtccag   2160

tcctgaatca tcttggagaa acaccttggt ttctaggatg gttttgtgtg gagggggagg   2220

taggactggg ctggatgaga gagcacagct gtgacttcct cctaactgtc agggtgggga   2280

gctggttccc agaggattgt ctaccctgaa gtccatcagg ttttctgttg cacaaggacg   2340

ggtcaggaag gaaggagagg cttttccaga aacaaaaaat ctgtgagggt ctgacttgct   2400

caaaccagag gaggaaacag aaacccctgc acatcttttt agggggttct ttgacccagg   2460

atagtcttgc ttcttgaggt agatcacagg ggtctgtgta cctctgaatt catgagagat   2520

gaatgacaga tgctctcatg ggtctagata ttgaggagtt tttctgaggg cagagattgg   2580

acatcaacaa ggctagaagg gtcagggaag tgggctaaag gaacagattc ctagagatta   2640

atgaagagga gggaggtttc tttggtcttc tattccaagg gtaaggttgc gattatgggt   2700

aagattggcc agaggtagga atgtggggag aaggagaggc tgaaaagaaa gcagaggaga   2760

acccaggtcc ctgcctcagc cttcagcaga gttggcttat tgcctgcctc tataccaata   2820

agtcagtcac cttgctcctc tccagaggca aagtggaaga gatcctgcaa gacacatcta   2880

tcctttcaca gtgttcccaa gggaacttgg aaaggagagt caggtattag aggaaagaga   2940

agggtatttg tatacaaagc cctggcctta aagaatgtta cttagtagct actcccaaat   3000

tgtcagcctt cttacctggc caaggtgtcc aagccagaaa ggaaaaaagg ttatggagtc   3060

tttctcaccc taaggacagg gtggaagagg gtggtatata gggaagggcc agataggcaa   3120

cttcatttgg cttgtgtgca tctggcctgg aactggtgtt aagccaggct tttgcttgtt   3180

tgttgccatc cctcaccctt tgccatttcc cttttcagag aatgtaaatg attttcatgt   3240

taggccaaaa taaacaactt atagggtaca tatgttgtca taaaaggtaa aagtgatgca   3300

tgccaaacca aactaaacca atttggatta tctgctattc gggtaatctt cacagaaatg   3360

actgagagaa gaatctgcag tttactgagg gcatttcagt tcctcctacc acctcaacag   3420

gactttgtcc agactctcct cctcttacct ttgtgccttg actgtggttc tttgtggcaa   3480

gatactttgg ttggttaaaa taatatggaa caaaggatcc actgaagtga aaaaaaaaaa   3540

aaaaa                                                               3545


<210>  1417
<211>  488
<212>  PRT
<213>  Homosapiens

<400>  1417

Met Ala Glu Thr Ser Leu Leu Glu Ala Gly Ala Ser Ala Ala Ser Thr 
1               5                   10                  15      


Ala Ala Ala Leu Glu Asn Leu Gln Val Glu Ala Ser Cys Ser Val Cys 
            20                  25                  30          


Leu Glu Tyr Leu Lys Glu Pro Val Ile Ile Glu Cys Gly His Asn Phe 
        35                  40                  45              


Cys Lys Ala Cys Ile Thr Arg Trp Trp Glu Asp Leu Glu Arg Asp Phe 
    50                  55                  60                  


Pro Cys Pro Val Cys Arg Lys Thr Ser Arg Tyr Arg Ser Leu Arg Pro 
65                  70                  75                  80  


Asn Arg Gln Leu Gly Ser Met Val Glu Ile Ala Lys Gln Leu Gln Ala 
                85                  90                  95      


Val Lys Arg Lys Ile Arg Asp Glu Ser Leu Cys Pro Gln His His Glu 
            100                 105                 110         


Ala Leu Ser Leu Phe Cys Tyr Glu Asp Gln Glu Ala Val Cys Leu Ile 
        115                 120                 125             


Cys Ala Ile Ser His Thr His Arg Ala His Thr Val Val Pro Leu Asp 
    130                 135                 140                 


Asp Ala Thr Gln Glu Tyr Lys Glu Lys Leu Gln Lys Cys Leu Glu Pro 
145                 150                 155                 160 


Leu Glu Gln Lys Leu Gln Glu Ile Thr Arg Cys Lys Ser Ser Glu Glu 
                165                 170                 175     


Lys Lys Pro Gly Glu Leu Lys Arg Leu Val Glu Ser Arg Arg Gln Gln 
            180                 185                 190         


Ile Leu Arg Glu Phe Glu Glu Leu His Arg Arg Leu Asp Glu Glu Gln 
        195                 200                 205             


Gln Val Leu Leu Ser Arg Leu Glu Glu Glu Glu Gln Asp Ile Leu Gln 
    210                 215                 220                 


Arg Leu Arg Glu Asn Ala Ala His Leu Gly Asp Lys Arg Arg Asp Leu 
225                 230                 235                 240 


Ala His Leu Ala Ala Glu Val Glu Gly Lys Cys Leu Gln Ser Gly Phe 
                245                 250                 255     


Glu Met Leu Lys Asp Val Lys Ser Thr Leu Glu Lys Cys Glu Lys Val 
            260                 265                 270         


Lys Thr Met Glu Val Thr Ser Val Ser Ile Glu Leu Glu Lys Asn Phe 
        275                 280                 285             


Ser Asn Phe Pro Arg Gln Tyr Phe Ala Leu Arg Lys Ile Leu Lys Gln 
    290                 295                 300                 


Leu Ile Ala Asp Val Thr Leu Asp Pro Glu Thr Ala His Pro Asn Leu 
305                 310                 315                 320 


Val Leu Ser Glu Asp Arg Lys Ser Val Lys Phe Val Glu Thr Arg Leu 
                325                 330                 335     


Arg Asp Leu Pro Asp Thr Pro Arg Arg Phe Thr Phe Tyr Pro Cys Val 
            340                 345                 350         


Leu Ala Thr Glu Gly Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu 
        355                 360                 365             


Val Gly Asp Lys Thr His Trp Ala Val Gly Val Cys Arg Asp Ser Val 
    370                 375                 380                 


Ser Arg Lys Gly Glu Leu Thr Pro Leu Pro Glu Thr Gly Tyr Trp Arg 
385                 390                 395                 400 


Val Arg Leu Trp Asn Gly Asp Lys Tyr Ala Ala Thr Thr Thr Pro Phe 
                405                 410                 415     


Thr Pro Leu His Ile Lys Val Lys Pro Lys Arg Val Gly Ile Phe Leu 
            420                 425                 430         


Asp Tyr Glu Ala Gly Thr Leu Ser Phe Tyr Asn Val Thr Asp Arg Ser 
        435                 440                 445             


His Ile Tyr Thr Phe Thr Asp Thr Phe Thr Glu Lys Leu Trp Pro Leu 
    450                 455                 460                 


Phe Tyr Pro Gly Ile Arg Ala Gly Arg Lys Asn Ala Ala Pro Leu Thr 
465                 470                 475                 480 


Ile Arg Pro Pro Thr Asp Trp Glu 
                485             


<210>  1418
<211>  541
<212>  DNA
<213>  Homosapiens

<400>  1418
agcgcggcgg tgatggcggg gccggtgaag gaccgcgagg ccttccagag gctcaacttc     60

ctgtaccagg ccgcccattg tgtccttgcc caggaccccg agaaccaggc gctggcgagg    120

ttttactgct acactgagag gaccattgcg aagcggctcg tcttgcggcg ggatccctcg    180

gtgaagagga ctctctgccg aggctgctct tccctcctcg tcccgggcct cacctgcacc    240

cagcgccaga gacgctgcag gggacagcgc tggaccgtac agacctgcct aacatgccag    300

cgcagccaac gcttcctcaa tgatcccggg catttactct ggggagacag gcctgaggcc    360

cagctcggga gccaagcaga ttccaaacca ctacaaccct tgccaaacac agcccactcc    420

atttcagacc gccttcctga ggagaaaatg cagactcagg gttccagtaa ccagtgatgg    480

attcacccca tctcccaaat aaagtttact tgttttacat tcaaaaaaaa aaaaaaaaaa    540

a                                                                    541


<210>  1419
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  1419

Met Ala Gly Pro Val Lys Asp Arg Glu Ala Phe Gln Arg Leu Asn Phe 
1               5                   10                  15      


Leu Tyr Gln Ala Ala His Cys Val Leu Ala Gln Asp Pro Glu Asn Gln 
            20                  25                  30          


Ala Leu Ala Arg Phe Tyr Cys Tyr Thr Glu Arg Thr Ile Ala Lys Arg 
        35                  40                  45              


Leu Val Leu Arg Arg Asp Pro Ser Val Lys Arg Thr Leu Cys Arg Gly 
    50                  55                  60                  


Cys Ser Ser Leu Leu Val Pro Gly Leu Thr Cys Thr Gln Arg Gln Arg 
65                  70                  75                  80  


Arg Cys Arg Gly Gln Arg Trp Thr Val Gln Thr Cys Leu Thr Cys Gln 
                85                  90                  95      


Arg Ser Gln Arg Phe Leu Asn Asp Pro Gly His Leu Leu Trp Gly Asp 
            100                 105                 110         


Arg Pro Glu Ala Gln Leu Gly Ser Gln Ala Asp Ser Lys Pro Leu Gln 
        115                 120                 125             


Pro Leu Pro Asn Thr Ala His Ser Ile Ser Asp Arg Leu Pro Glu Glu 
    130                 135                 140                 


Lys Met Gln Thr Gln Gly Ser Ser Asn Gln 
145                 150                 


<210>  1420
<211>  1701
<212>  DNA
<213>  Homosapiens

<400>  1420
cggactcaag aagttctcag gactcagagg ctgggatcat ggtagatgga accctccttt     60

tactcctctc ggaggccctg gcccttaccc agacctgggc gggctcccac tccttgaagt    120

atttccacac ttccgtgtcc cggcccggcc gcggggagcc ccgcttcatc tctgtgggct    180

acgtggacga cacccagttc gtgcgcttcg acaacgacgc cgcgagtccg aggatggtgc    240

cgcgggcgcc gtggatggag caggaggggt cagagtattg ggaccgggag acacggagcg    300

ccagggacac cgcacagatt ttccgagtga acctgcggac gctgcgcggc tactacaatc    360

agagcgaggc cgggtctcac accctgcagt ggatgcatgg ctgcgagctg gggcccgacg    420

ggcgcttcct ccgcgggtat gaacagttcg cctacgacgg caaggattat ctcaccctga    480

atgaggacct gcgctcctgg accgcggtgg acacggcggc tcagatctcc gagcaaaagt    540

caaatgatgc ctctgaggcg gagcaccaga gagcctacct ggaagacaca tgcgtggagt    600

ggctccacaa atacctggag aaggggaagg agacgctgct tcacctggag cccccaaaga    660

cacacgtgac tcaccacccc atctctgacc atgaggccac cctgaggtgc tgggccctgg    720

gcttctaccc tgcggagatc acactgacct ggcagcagga tggggagggc catacccagg    780

acacggagct cgtggagacc aggcctgcag gggatggaac cttccagaag tgggcagctg    840

tggtggtgcc ttctggagag gagcagagat acacgtgcca tgtgcagcat gaggggctac    900

ccgagcccgt caccctgaga tggaagccgg cttcccagcc caccatcccc atcgtgggca    960

tcattgctgg cctggttctc cttggatctg tggtctctgg agctgtggtt gctgctgtga   1020

tatggaggaa gaagagctca ggtggaaaag gagggagcta ctctaaggct gagtggagcg   1080

acagtgccca ggggtctgag tctcacagct tgtaaagcct gagacagctg ccttgtgtgc   1140

gactgagatg cacagctgcc ttgtgtgcga ctgagatgca ggatttcctc acgcctcccc   1200

tatgtgtctt aggggactct ggcttctctt tttgcaaggg cctctgaatc tgtctgtgtc   1260

cctgttagca caatgtgagg aggtagagaa acagtccacc tctgtgtcta ccatgacccc   1320

cttcctcaca ctgacctgtg ttccttccct gttctctttt ctattaaaaa taagaacctg   1380

ggcagagtgc ggcagctcat gcctgtaatc ccagcactta gggaggccga ggagggcaga   1440

tcacgaggtc aggagatcga aaccatcctg gctaacacgg tgaaaccccg tctctactaa   1500

aaaatacaaa aaattagctg ggcgcagagg cacgggcctg tagtcccagc tactcaggag   1560

gcggaggcag gagaatggcg tcaacccggg aggcggaggt tgcagtgagc caggattgtg   1620

cgactgcact ccagcctggg tgacagggtg aaacgccatc tcaaaaaata aaaattgaaa   1680

aataaaaaaa aaaaaaaaaa a                                             1701


<210>  1421
<211>  358
<212>  PRT
<213>  Homosapiens

<400>  1421

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210>  1422
<211>  3023
<212>  DNA
<213>  Homosapiens

<400>  1422
attccacttc cggaaggttg cggagaacat ctgcggcggc cgcattccgg agccaactgc     60

ctccctccgt ctctgccagg catggcggca acctcacacc ttccctttgc tgcgtttcta    120

taaatgcttt gaaaaaatta ctcttttctt ccctcgctgg aaaacaccac aaccagctcc    180

tcagagtgtg tcacagagtc aacaggctct cgggccagag ggcctgagaa gaggactgtc    240

gcaccgtaag atcgccacat ccggtcctcg gttactatgg taacagctgc aggcacaact    300

tcgtgccctt tgacctcccc ccaaaagtcc ttgtcccgct tgggtttccc ttctcgcccg    360

cttttgcact tatgatctgt aaacctgctc cttatcatcg ttcccacaag gaatttgggt    420

cccaacaggt cggcacccag gactctcaga ccgccgccct cccctaaaga cctctgaccg    480

tgcccccggt gtagtccagc aacctggacg cagtctcggc tttccactaa ggtcaagccc    540

ggggctttgt agtatagcct cagcgtgtcc acgccccctc tcccctaggt agtaggcccc    600

gccctccgct ccgccgcccc ctccaggtga gtggtaggtt ctcccgggag cgcaaggtag    660

tgatgacacg cgccccccct cctccgaacg cgagttggta gcgtccgtga cggagttagc    720

ctggtcctcc cacgcgcgcc tccttcctcg ccgccggggc gccctctcgg tgccactggc    780

tctcacgtgc cagtagccca ccccgcatca tcctctcgcc tcgctcctgg agggaagtga    840

ctatatctcc cccgtccgcc ttccatcgcc gccgcggcgg taattctgtc gggcccgccc    900

gctgacgtca cctgctagcc ccgcctcctc tagggtcccg ggcccctgcg gcgggggctg    960

ccccgggggg cagtcagttg aggcggcggg agctcggcgg agggcgggcc aggtgactgg   1020

tccgggccat gccgaggaag aagccattca gcgtgaagca gaagaagaag cagttgcagg   1080

acaaacggga gcggaagaga gggcttcaag atgggctgcg ctccagttcc aacagccgca   1140

gcgggagccg ggagcggcga gaggaacaga ccgacacctc ggacggggag tctgtgaccc   1200

atcatatccg caggcttaac cagcagcctt ctcaggggct gggtccacga ggctacgacc   1260

caaatcgata ccgactgcat tttgagagag acagcaggga ggaggtagag aggagaaaga   1320

gagcagcccg ggagcaagtt ctacagccgg tcagtgctga gttgttggag ctggacatcc   1380

gggaggtgta tcagcctggc tcagttctgg actttcctcg acgtcctcct tggagctatg   1440

agatgtccaa ggagcaacta atgagccaag aggaacggag cttccaagac tatcttggga   1500

agattcatgg ggcttactcc tctgagaaac tcagctactt tgagcacaat ctggagacat   1560

ggaggcagct gtggcgggtg ttagagatgt ctgacatcgt cctgcttatc actgatatcc   1620

gacatccagt tgtgaatttc ccgccagcac tttatgagta tgtgactgga gaacttggac   1680

tggccctggt gctggttttg aacaaggtgg atctggcccc gccagctctt gtggttgcct   1740

ggaagcatta tttccatcaa cactatcccc agctccacgt cgtccttttc acctcttttc   1800

ctcgggaccc ccgcacccca caggatccta gtagtgtctt gaagaagagt cggaggcggg   1860

ggagaggatg gactcgggcc ctggggccag agcagttgct gagagcctgt gaagccatca   1920

ctgtggggaa agtggacttg agcagctggc gggagaagat tgctcgggat gtggctgggg   1980

ccacctgggg taatggctct ggggaggagg aggaagagga ggatggccca gcagtcctgg   2040

tggagcagca gactgattca gcaatggagc caactggccc aacccaagag cgctacaagg   2100

atggggtggt gaccatcggc tgtgtgggtt tccctaatgt gggaaagtcc tcgctgatca   2160

atgggctggt ggggcggaaa gtcgtgagtg tctccagaac cccgggccat acccgatact   2220

ttcagaccta ctttcttacc ccctctgtga agctctgtga ctgcccaggc ctcatcttcc   2280

catctcttct gcctaggcag ttgcaggttc tggcagggat ctaccctatc gcccagatcc   2340

aggagcccta cactgctgtg ggctacctgg cctcccgaat tcccgtgcag gccctgctcc   2400

acctgcgcca cccagaggct gaggacccct cagcggaaca cccctggtgt gcctgggaca   2460

tctgtgaagc ctgggcagag aaacgtggtt acaagacagc caaggcggct cggaatgatg   2520

tgtacagagc agccaacagt ctcttgcggc tggcagtgga cggccgcctc agcctgtgtt   2580

ttcatccccc aggctacagt gaacagaaag gcacctggga gtcccatcca gagaccacgg   2640

agctggtggt tttgcagggc agggtggggc cagcaggtga cgaggaggag gaggaagagg   2700

aagagctgag cagctcctgt gaggaggagg gagaggagga ccgggatgcg gatgaggagg   2760

gagaagggga tgaggagacc ccaacctcgg ctccagggtc cagcctggct ggccgaaacc   2820

cttatgccct gctgggtgag gatgagtgct gagttcctcg cccagcgcca tcttccctcc   2880

cagtatcttt gcttttggac tgacctgggg gtatctcccc tctgccaccc caattgtgaa   2940

taaagattgt ttgctttgta gccccttccc cagatgaact gaggtgagag cggctgttcc   3000

aggctaaaaa aaaaaaaaaa aaa                                           3023


<210>  1423
<211>  607
<212>  PRT
<213>  Homosapiens

<400>  1423

Met Pro Arg Lys Lys Pro Phe Ser Val Lys Gln Lys Lys Lys Gln Leu 
1               5                   10                  15      


Gln Asp Lys Arg Glu Arg Lys Arg Gly Leu Gln Asp Gly Leu Arg Ser 
            20                  25                  30          


Ser Ser Asn Ser Arg Ser Gly Ser Arg Glu Arg Arg Glu Glu Gln Thr 
        35                  40                  45              


Asp Thr Ser Asp Gly Glu Ser Val Thr His His Ile Arg Arg Leu Asn 
    50                  55                  60                  


Gln Gln Pro Ser Gln Gly Leu Gly Pro Arg Gly Tyr Asp Pro Asn Arg 
65                  70                  75                  80  


Tyr Arg Leu His Phe Glu Arg Asp Ser Arg Glu Glu Val Glu Arg Arg 
                85                  90                  95      


Lys Arg Ala Ala Arg Glu Gln Val Leu Gln Pro Val Ser Ala Glu Leu 
            100                 105                 110         


Leu Glu Leu Asp Ile Arg Glu Val Tyr Gln Pro Gly Ser Val Leu Asp 
        115                 120                 125             


Phe Pro Arg Arg Pro Pro Trp Ser Tyr Glu Met Ser Lys Glu Gln Leu 
    130                 135                 140                 


Met Ser Gln Glu Glu Arg Ser Phe Gln Asp Tyr Leu Gly Lys Ile His 
145                 150                 155                 160 


Gly Ala Tyr Ser Ser Glu Lys Leu Ser Tyr Phe Glu His Asn Leu Glu 
                165                 170                 175     


Thr Trp Arg Gln Leu Trp Arg Val Leu Glu Met Ser Asp Ile Val Leu 
            180                 185                 190         


Leu Ile Thr Asp Ile Arg His Pro Val Val Asn Phe Pro Pro Ala Leu 
        195                 200                 205             


Tyr Glu Tyr Val Thr Gly Glu Leu Gly Leu Ala Leu Val Leu Val Leu 
    210                 215                 220                 


Asn Lys Val Asp Leu Ala Pro Pro Ala Leu Val Val Ala Trp Lys His 
225                 230                 235                 240 


Tyr Phe His Gln His Tyr Pro Gln Leu His Val Val Leu Phe Thr Ser 
                245                 250                 255     


Phe Pro Arg Asp Pro Arg Thr Pro Gln Asp Pro Ser Ser Val Leu Lys 
            260                 265                 270         


Lys Ser Arg Arg Arg Gly Arg Gly Trp Thr Arg Ala Leu Gly Pro Glu 
        275                 280                 285             


Gln Leu Leu Arg Ala Cys Glu Ala Ile Thr Val Gly Lys Val Asp Leu 
    290                 295                 300                 


Ser Ser Trp Arg Glu Lys Ile Ala Arg Asp Val Ala Gly Ala Thr Trp 
305                 310                 315                 320 


Gly Asn Gly Ser Gly Glu Glu Glu Glu Glu Glu Asp Gly Pro Ala Val 
                325                 330                 335     


Leu Val Glu Gln Gln Thr Asp Ser Ala Met Glu Pro Thr Gly Pro Thr 
            340                 345                 350         


Gln Glu Arg Tyr Lys Asp Gly Val Val Thr Ile Gly Cys Val Gly Phe 
        355                 360                 365             


Pro Asn Val Gly Lys Ser Ser Leu Ile Asn Gly Leu Val Gly Arg Lys 
    370                 375                 380                 


Val Val Ser Val Ser Arg Thr Pro Gly His Thr Arg Tyr Phe Gln Thr 
385                 390                 395                 400 


Tyr Phe Leu Thr Pro Ser Val Lys Leu Cys Asp Cys Pro Gly Leu Ile 
                405                 410                 415     


Phe Pro Ser Leu Leu Pro Arg Gln Leu Gln Val Leu Ala Gly Ile Tyr 
            420                 425                 430         


Pro Ile Ala Gln Ile Gln Glu Pro Tyr Thr Ala Val Gly Tyr Leu Ala 
        435                 440                 445             


Ser Arg Ile Pro Val Gln Ala Leu Leu His Leu Arg His Pro Glu Ala 
    450                 455                 460                 


Glu Asp Pro Ser Ala Glu His Pro Trp Cys Ala Trp Asp Ile Cys Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Lys Arg Gly Tyr Lys Thr Ala Lys Ala Ala Arg Asn 
                485                 490                 495     


Asp Val Tyr Arg Ala Ala Asn Ser Leu Leu Arg Leu Ala Val Asp Gly 
            500                 505                 510         


Arg Leu Ser Leu Cys Phe His Pro Pro Gly Tyr Ser Glu Gln Lys Gly 
        515                 520                 525             


Thr Trp Glu Ser His Pro Glu Thr Thr Glu Leu Val Val Leu Gln Gly 
    530                 535                 540                 


Arg Val Gly Pro Ala Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Leu 
545                 550                 555                 560 


Ser Ser Ser Cys Glu Glu Glu Gly Glu Glu Asp Arg Asp Ala Asp Glu 
                565                 570                 575     


Glu Gly Glu Gly Asp Glu Glu Thr Pro Thr Ser Ala Pro Gly Ser Ser 
            580                 585                 590         


Leu Ala Gly Arg Asn Pro Tyr Ala Leu Leu Gly Glu Asp Glu Cys 
        595                 600                 605         


<210>  1424
<211>  2261
<212>  DNA
<213>  Homosapiens

<400>  1424
aacccaagcg ggacaaggac ttttgggggg aggtcaaagg gcacgaagtt gtgcctacag     60

ctgttaccat agtaaccgag gaccggatgt ggcgatcttg gcggtgcgac agtcctcttc    120

tcaggccctc tggcccgaga gcctgttgac tctgtgacac actctgagga gctggttgtg    180

gtgttttcca gcgagggaag aaaagagtaa ttttttcaaa gcatttatag aaacgcagca    240

aagggaaggt gtgaggttgc cgccatgcct ggcagaacgg agggaggcag ttggctccgg    300

aatgcggccg ccgcagatgt tctccgcaac cttccggaag tggaatggcg ggagcctcag    360

cattgctgcc caccgacccc ccggaagcgg aaacagaatc cccgcgtgcc ccttcctcac    420

taccctccaa atcccgctgc agccattgcc gcagacacga tgccgaaacg aaagaagcag    480

aatcatcacc agccaccgac acagcagcag cccccgctgc ccgagcggga agagactgga    540

gatgaggagg atgggagtcc catcggacca cccagccttc tgggccctcc ccccatggcc    600

aatggaaaac ctggcgaccc taagtcagct cttcacagag gtcctccagg atcaagggga    660

ccactgattc caccactgct gagtctccca cctcctcctt ggggtagagg cccaattcgg    720

agagggcttg gccccaggtc tagcccatat ggtcgtggtt ggtggggagt caatgcagaa    780

cctccttttc cggggccagg ccatgggggt cccaccaggg gaagctttca caaggaacag    840

agaaaccctc gaaggctcaa aagctggtct cttatcaaga atacctgccc gcccaaggat    900

gacccccagg ttatggaaga caaatccgac cgccctgtct gccgacattt tgccaaaaag    960

ggccactgtc gatatgagga cctctgtgcc ttctaccatc caggcgtcaa tggacctcct   1020

ctgtgagact gtgccttccc atccaggctg gaaggagctc tctgtgacct agcggccatt   1080

tatttctctg tagccctatg atggctactg tgaggctctt ctaacaccct cagtcagtga   1140

cacacccatc ccatccacca cttcccccgt gtggggtcca gagtggtgtt gcatcactgg   1200

tgcgcggcat acgcgctttc ttctgatcca gcctgtagag actcgccttt gggacccatc   1260

tttgcttcct ttcagttgcc tcctggatct tctttcccgt catcaaatga ctgctgaaca   1320

ggaaacctct ttggtgctgt ttcttgtgca tctgtccacc tgttccccag tattgccctc   1380

aattcctgag agccctggag cggtttccta ccattccctt cttttagctg cttgttttaa   1440

gtccttttta tgtgacattc cctaccccca atgttgtcag ctgcttgtga aactcagcca   1500

ggttgtctaa cctggggtca agtttgggtg actggtgcag agttacttcc taaaaggcca   1560

ctctccctgc ctttggattt catagtttct ctgtcagtag catgatcccc accgctatgg   1620

tctatctatg atcaccgtgc tttgtgaaac tgtgcatccc cttgtagcct ttctcagtgt   1680

ccgtggcatt tttgtgactt cccagcacta gaataagttt tcctgccaaa atgagtgagg   1740

cgcttggtgc cctctggact ttcccacttc ccaacatggg agaattgtga actttccatc   1800

agactgcctc cctggccctc cccattcttc tcctgttggt tattctgagt ctgacacaga   1860

cccatgacat gtcttataaa gcctccaatg gctttatcct acctagatcc cttccagccc   1920

attttaatta gactatgtca ttgtgaggcc accagtccat tcatttgaat tctgtgaatc   1980

tccaccttgc ctatctttgg gtagaagctg gacagtactg ttgccctctt ccaatcctct   2040

tcccctacat ccctggcact ggttgttttc tgtgaaaaca gcagtgaaca ggttcagttt   2100

tgaactggcc ctgaggaaat gggtcaggag ttgtattggc aagagggagg ggtgagagct   2160

gttggagaac tgagaatgag gttttttttt tttttttctt tttaactttt tttatattag   2220

taataaatgc agtggaaacc agcattttat ttaaaaaaaa a                       2261


<210>  1425
<211>  253
<212>  PRT
<213>  Homosapiens

<400>  1425

Met Pro Gly Arg Thr Glu Gly Gly Ser Trp Leu Arg Asn Ala Ala Ala 
1               5                   10                  15      


Ala Asp Val Leu Arg Asn Leu Pro Glu Val Glu Trp Arg Glu Pro Gln 
            20                  25                  30          


His Cys Cys Pro Pro Thr Pro Arg Lys Arg Lys Gln Asn Pro Arg Val 
        35                  40                  45              


Pro Leu Pro His Tyr Pro Pro Asn Pro Ala Ala Ala Ile Ala Ala Asp 
    50                  55                  60                  


Thr Met Pro Lys Arg Lys Lys Gln Asn His His Gln Pro Pro Thr Gln 
65                  70                  75                  80  


Gln Gln Pro Pro Leu Pro Glu Arg Glu Glu Thr Gly Asp Glu Glu Asp 
                85                  90                  95      


Gly Ser Pro Ile Gly Pro Pro Ser Leu Leu Gly Pro Pro Pro Met Ala 
            100                 105                 110         


Asn Gly Lys Pro Gly Asp Pro Lys Ser Ala Leu His Arg Gly Pro Pro 
        115                 120                 125             


Gly Ser Arg Gly Pro Leu Ile Pro Pro Leu Leu Ser Leu Pro Pro Pro 
    130                 135                 140                 


Pro Trp Gly Arg Gly Pro Ile Arg Arg Gly Leu Gly Pro Arg Ser Ser 
145                 150                 155                 160 


Pro Tyr Gly Arg Gly Trp Trp Gly Val Asn Ala Glu Pro Pro Phe Pro 
                165                 170                 175     


Gly Pro Gly His Gly Gly Pro Thr Arg Gly Ser Phe His Lys Glu Gln 
            180                 185                 190         


Arg Asn Pro Arg Arg Leu Lys Ser Trp Ser Leu Ile Lys Asn Thr Cys 
        195                 200                 205             


Pro Pro Lys Asp Asp Pro Gln Val Met Glu Asp Lys Ser Asp Arg Pro 
    210                 215                 220                 


Val Cys Arg His Phe Ala Lys Lys Gly His Cys Arg Tyr Glu Asp Leu 
225                 230                 235                 240 


Cys Ala Phe Tyr His Pro Gly Val Asn Gly Pro Pro Leu 
                245                 250             


<210>  1426
<211>  3474
<212>  DNA
<213>  Homosapiens

<400>  1426
gcgccagctt ggagagccag ccccatcggg gttccccgcc gccggaagcg gaaatagcac     60

cgggcgccgc cacagtagct gtaactgcca ccgcgatgcc gaaggcgccc aagcagcagc    120

cgccggagcc cgagtggatc ggggacggag agagcacgag cccatcagac aaagtggtga    180

agaaagggaa gaaggacaag aagatcaaaa aaacgttctt tgaagagctg gcagtagaag    240

ataaacaggc tggggaagaa gagaaagtgc tcaaggagaa ggagcagcag cagcagcaac    300

agcaacagca gcaaaaaaaa aagcgagata cccgaaaagg caggcggaag aaggatgtgg    360

atgatgatgg agaagagaaa gagctcatgg agcgtcttaa gaagctctca gtgccaacca    420

gtgatgagga ggatgaagta cccgccccaa aaccccgcgg agggaagaaa accaagggtg    480

gtaatgtttt tgcagccctg attcaggatc agagtgagga agaggaggag gaagaaaaac    540

atcctcctaa gcctgccaag ccggagaaga atcggatcaa taaggccgta tctgaggaac    600

agcagcctgc actcaagggc aaaaagggaa aggaagagaa gtcaaaaggg aaggctaagc    660

ctcaaaataa attcgctgct ctggacaatg aagaggagga taaagaagaa gaaattataa    720

aggaaaagga gcctcccaaa caagggaagg agaaggccaa gaaggcagag cagggttcag    780

aggaagaagg agaaggggaa gaagaggagg aggaaggagg agagtctaag gcagatgatc    840

cctatgctca tcttagcaaa aaggagaaga aaaagctgaa aaaacagatg gagtatgagc    900

gccaagtggc ttcattaaaa gcagccaatg cagctgaaaa tgacttctcc gtgtcccagg    960

cggagatgtc ctcccgccaa gccatgttag aaaatgcatc tgacatcaag ctggagaagt   1020

tcagcatctc cgctcatggc aaggagctgt tcgtcaatgc agacctgtac attgtagccg   1080

gccgccgcta cgggctggta ggacccaatg gcaagggcaa gaccacactc ctcaagcaca   1140

ttgccaaccg agccctgagc atccctccca acattgatgt gttgctgtgt gagcaggagg   1200

tggtagcaga tgagacacca gcagtccagg ctgttcttcg agctgacacc aagcgattga   1260

agctgctgga agaggagcgg cggcttcagg gacagctgga acaaggggat gacacagctg   1320

ctgagaggct agagaaggtg tatgaggaat tgcgggccac tggggcggca gctgcagagg   1380

ccaaagcacg gcggatcctg gctggcctgg gctttgaccc tgaaatgcag aatcgaccca   1440

cacagaagtt ctcagggggc tggcgcatgc gtgtctccct ggccagggca ctgttcatgg   1500

agcccacact gctgatgctg gatgagccca ccaaccacct ggacctcaac gctgtcatct   1560

ggcttaataa ctacctccag ggctggcgga agaccttgct gatcgtctcc catgaccagg   1620

gcttcttgga tgatgtctgc actgatatca tccacctcga tgcccagcgg ctccactact   1680

ataggggcaa ttacatgacc ttcaaaaaga tgtaccagca gaagcagaaa gaactgctga   1740

aacagtatga gaagcaagag aaaaagctga aggagctgaa ggcaggcggg aagtccacca   1800

agcaggcgga aaaacaaacg aaggaagccc tgactcggaa gcagcagaaa tgccgacgga   1860

aaaaccaaga tgaggaatcc caggaggccc ctgagctcct gaagcgccct aaggagtaca   1920

ctgtgcgctt cacttttcca gaccccccac cactcagccc tccagtgctg ggtctgcatg   1980

gtgtgacatt cggctaccag ggacagaaac cactctttaa gaacttggat tttggcatcg   2040

acatggattc aaggatttgc attgtgggcc ctaatggtgt ggggaagagt acgctactcc   2100

tgctgctgac tggcaagctg acaccgaccc atggggaaat gagaaagaac caccggctga   2160

aaattggctt cttcaaccag cagtatgcag agcagctgcg catggaggag acgcccactg   2220

agtacctgca gcggggcttc aacctgccct accaggatgc ccgcaagtgc ctgggccgct   2280

tcggcctgga gagtcacgcc cacaccatcc agatctgcaa actctctggt ggtcagaagg   2340

cgcgagttgt gtttgctgag ctggcctgtc gggaacctga tgtcctcatc ttggacgagc   2400

caaccaataa cctggacata gagtctattg atgctctagg ggaggccatc aatgaataca   2460

agggtgctgt gatcgttgtc agccatgatg cccgactcat cacagaaacc aattgccagc   2520

tgtgggtggt ggaggagcag agtgttagcc aaatcgatgg tgactttgaa gactacaagc   2580

gggaggtgtt ggaggccctg ggtgaagtca tggtcagccg gccccgagag tgagctttcc   2640

ttcccagaag tctcccgaga gacatatttg tgtggcctag aagtcctctg tggtctcccc   2700

tcctctgaag actgcctctg gcctgcagct gacctggcaa ccattcaggc acatgaaggt   2760

ggagtgtgac cttgatgtga ccgggatccc actctgattg catccatttc tctgaaagac   2820

ttgtttgttc tgcttctctt catataactg agctggcctt atccttggca tccccctaaa   2880

caaacaagag gtgaccacct tattgtgagg ttccatccag ccaagtttat gtggcctatt   2940

gtctcaggac tctcatcact cagaagcctg cctctgattt accctacagc ttcaggccca   3000

gctgcccccc agtctttggg tggtgctgtt cttttctggt ggatttaatg ctgactcact   3060

ggtacaaaca gctgttgaag ctcagagctg gaggtgagct tctgaggcct ttgccattat   3120

ccagcccaag atttggtgcc tgcagcctct tgtctggttg aggacttggg gcaggaaagg   3180

aatgctgctg aacttgaatt tccctttaca aggggaagaa ataaaggaaa ggagttgctg   3240

ccgacctgtc actgtttgga gattgatggg agttggaact gttctcagtc ttgatttgct   3300

ttattcagtt ttctagcagc ttttaatagt cccctcttcc ccactaaatg gatcttgttt   3360

gcagtcttgc tgacagtgtt tgctgtttaa ggatcatagg attcctttcc cccaaccctt   3420

cacgcaagga aaaagcaaag tgattcatac cttctatctt ggaaaaaaaa aaaa         3474


<210>  1427
<211>  845
<212>  PRT
<213>  Homosapiens

<400>  1427

Met Pro Lys Ala Pro Lys Gln Gln Pro Pro Glu Pro Glu Trp Ile Gly 
1               5                   10                  15      


Asp Gly Glu Ser Thr Ser Pro Ser Asp Lys Val Val Lys Lys Gly Lys 
            20                  25                  30          


Lys Asp Lys Lys Ile Lys Lys Thr Phe Phe Glu Glu Leu Ala Val Glu 
        35                  40                  45              


Asp Lys Gln Ala Gly Glu Glu Glu Lys Val Leu Lys Glu Lys Glu Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys Lys Lys Arg Asp Thr Arg 
65                  70                  75                  80  


Lys Gly Arg Arg Lys Lys Asp Val Asp Asp Asp Gly Glu Glu Lys Glu 
                85                  90                  95      


Leu Met Glu Arg Leu Lys Lys Leu Ser Val Pro Thr Ser Asp Glu Glu 
            100                 105                 110         


Asp Glu Val Pro Ala Pro Lys Pro Arg Gly Gly Lys Lys Thr Lys Gly 
        115                 120                 125             


Gly Asn Val Phe Ala Ala Leu Ile Gln Asp Gln Ser Glu Glu Glu Glu 
    130                 135                 140                 


Glu Glu Glu Lys His Pro Pro Lys Pro Ala Lys Pro Glu Lys Asn Arg 
145                 150                 155                 160 


Ile Asn Lys Ala Val Ser Glu Glu Gln Gln Pro Ala Leu Lys Gly Lys 
                165                 170                 175     


Lys Gly Lys Glu Glu Lys Ser Lys Gly Lys Ala Lys Pro Gln Asn Lys 
            180                 185                 190         


Phe Ala Ala Leu Asp Asn Glu Glu Glu Asp Lys Glu Glu Glu Ile Ile 
        195                 200                 205             


Lys Glu Lys Glu Pro Pro Lys Gln Gly Lys Glu Lys Ala Lys Lys Ala 
    210                 215                 220                 


Glu Gln Gly Ser Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Glu Glu 
225                 230                 235                 240 


Gly Gly Glu Ser Lys Ala Asp Asp Pro Tyr Ala His Leu Ser Lys Lys 
                245                 250                 255     


Glu Lys Lys Lys Leu Lys Lys Gln Met Glu Tyr Glu Arg Gln Val Ala 
            260                 265                 270         


Ser Leu Lys Ala Ala Asn Ala Ala Glu Asn Asp Phe Ser Val Ser Gln 
        275                 280                 285             


Ala Glu Met Ser Ser Arg Gln Ala Met Leu Glu Asn Ala Ser Asp Ile 
    290                 295                 300                 


Lys Leu Glu Lys Phe Ser Ile Ser Ala His Gly Lys Glu Leu Phe Val 
305                 310                 315                 320 


Asn Ala Asp Leu Tyr Ile Val Ala Gly Arg Arg Tyr Gly Leu Val Gly 
                325                 330                 335     


Pro Asn Gly Lys Gly Lys Thr Thr Leu Leu Lys His Ile Ala Asn Arg 
            340                 345                 350         


Ala Leu Ser Ile Pro Pro Asn Ile Asp Val Leu Leu Cys Glu Gln Glu 
        355                 360                 365             


Val Val Ala Asp Glu Thr Pro Ala Val Gln Ala Val Leu Arg Ala Asp 
    370                 375                 380                 


Thr Lys Arg Leu Lys Leu Leu Glu Glu Glu Arg Arg Leu Gln Gly Gln 
385                 390                 395                 400 


Leu Glu Gln Gly Asp Asp Thr Ala Ala Glu Arg Leu Glu Lys Val Tyr 
                405                 410                 415     


Glu Glu Leu Arg Ala Thr Gly Ala Ala Ala Ala Glu Ala Lys Ala Arg 
            420                 425                 430         


Arg Ile Leu Ala Gly Leu Gly Phe Asp Pro Glu Met Gln Asn Arg Pro 
        435                 440                 445             


Thr Gln Lys Phe Ser Gly Gly Trp Arg Met Arg Val Ser Leu Ala Arg 
    450                 455                 460                 


Ala Leu Phe Met Glu Pro Thr Leu Leu Met Leu Asp Glu Pro Thr Asn 
465                 470                 475                 480 


His Leu Asp Leu Asn Ala Val Ile Trp Leu Asn Asn Tyr Leu Gln Gly 
                485                 490                 495     


Trp Arg Lys Thr Leu Leu Ile Val Ser His Asp Gln Gly Phe Leu Asp 
            500                 505                 510         


Asp Val Cys Thr Asp Ile Ile His Leu Asp Ala Gln Arg Leu His Tyr 
        515                 520                 525             


Tyr Arg Gly Asn Tyr Met Thr Phe Lys Lys Met Tyr Gln Gln Lys Gln 
    530                 535                 540                 


Lys Glu Leu Leu Lys Gln Tyr Glu Lys Gln Glu Lys Lys Leu Lys Glu 
545                 550                 555                 560 


Leu Lys Ala Gly Gly Lys Ser Thr Lys Gln Ala Glu Lys Gln Thr Lys 
                565                 570                 575     


Glu Ala Leu Thr Arg Lys Gln Gln Lys Cys Arg Arg Lys Asn Gln Asp 
            580                 585                 590         


Glu Glu Ser Gln Glu Ala Pro Glu Leu Leu Lys Arg Pro Lys Glu Tyr 
        595                 600                 605             


Thr Val Arg Phe Thr Phe Pro Asp Pro Pro Pro Leu Ser Pro Pro Val 
    610                 615                 620                 


Leu Gly Leu His Gly Val Thr Phe Gly Tyr Gln Gly Gln Lys Pro Leu 
625                 630                 635                 640 


Phe Lys Asn Leu Asp Phe Gly Ile Asp Met Asp Ser Arg Ile Cys Ile 
                645                 650                 655     


Val Gly Pro Asn Gly Val Gly Lys Ser Thr Leu Leu Leu Leu Leu Thr 
            660                 665                 670         


Gly Lys Leu Thr Pro Thr His Gly Glu Met Arg Lys Asn His Arg Leu 
        675                 680                 685             


Lys Ile Gly Phe Phe Asn Gln Gln Tyr Ala Glu Gln Leu Arg Met Glu 
    690                 695                 700                 


Glu Thr Pro Thr Glu Tyr Leu Gln Arg Gly Phe Asn Leu Pro Tyr Gln 
705                 710                 715                 720 


Asp Ala Arg Lys Cys Leu Gly Arg Phe Gly Leu Glu Ser His Ala His 
                725                 730                 735     


Thr Ile Gln Ile Cys Lys Leu Ser Gly Gly Gln Lys Ala Arg Val Val 
            740                 745                 750         


Phe Ala Glu Leu Ala Cys Arg Glu Pro Asp Val Leu Ile Leu Asp Glu 
        755                 760                 765             


Pro Thr Asn Asn Leu Asp Ile Glu Ser Ile Asp Ala Leu Gly Glu Ala 
    770                 775                 780                 


Ile Asn Glu Tyr Lys Gly Ala Val Ile Val Val Ser His Asp Ala Arg 
785                 790                 795                 800 


Leu Ile Thr Glu Thr Asn Cys Gln Leu Trp Val Val Glu Glu Gln Ser 
                805                 810                 815     


Val Ser Gln Ile Asp Gly Asp Phe Glu Asp Tyr Lys Arg Glu Val Leu 
            820                 825                 830         


Glu Ala Leu Gly Glu Val Met Val Ser Arg Pro Arg Glu 
        835                 840                 845 


<210>  1428
<211>  3360
<212>  DNA
<213>  Homosapiens

<400>  1428
gcgccagctt ggagagccag ccccatcggg gttccccgcc gccggaagcg gaaatagcac     60

cgggcgccgc cacagtagct gtaactgcca ccgcgatgcc gaaggcgccc aagcagcagc    120

cgccggagcc cgagtggatc ggggacggag agagcacgag cccatcagac aaagtggtga    180

agaaagggaa gaaggacaag aagatcaaaa aaacgttctt tgaagagctg gcagtagaag    240

ataaacaggc tggggaagaa gagaaagtgc tcaaggagaa ggagcagcag cagcagcaac    300

agcaacagca gcaaaaaaaa aagcgagata cccgaaaagg caggcggaag aaggatgtgg    360

atgatgatgg agaagagaaa gagctcatgg agcgtcttaa gaagctctca gtgccaacca    420

gtgatgagga ggatgaagta cccgccccaa aaccccgcgg agggaagaaa accaagggtg    480

gtaatgtttt tgcagccctg attcaggatc agagtgagga agaggaggag gaagaaaaac    540

atcctcctaa gcctgccaag ccggagaaga atcggatcaa taaggccgta tctgaggaac    600

agcagcctgc actcaagggc aaaaagggaa aggaagagaa gtcaaaaggg aaggctaagc    660

ctcaaaataa attcgctgct ctggacaatg aagaggagga taaagaagaa gaaattataa    720

aggaaaagga gcctcccaaa caagggaagg agaaggccaa gaaggcagag cagatggagt    780

atgagcgcca agtggcttca ttaaaagcag ccaatgcagc tgaaaatgac ttctccgtgt    840

cccaggcgga gatgtcctcc cgccaagcca tgttagaaaa tgcatctgac atcaagctgg    900

agaagttcag catctccgct catggcaagg agctgttcgt caatgcagac ctgtacattg    960

tagccggccg ccgctacggg ctggtaggac ccaatggcaa gggcaagacc acactcctca   1020

agcacattgc caaccgagcc ctgagcatcc ctcccaacat tgatgtgttg ctgtgtgagc   1080

aggaggtggt agcagatgag acaccagcag tccaggctgt tcttcgagct gacaccaagc   1140

gattgaagct gctggaagag gagcggcggc ttcagggaca gctggaacaa ggggatgaca   1200

cagctgctga gaggctagag aaggtgtatg aggaattgcg ggccactggg gcggcagctg   1260

cagaggccaa agcacggcgg atcctggctg gcctgggctt tgaccctgaa atgcagaatc   1320

gacccacaca gaagttctca gggggctggc gcatgcgtgt ctccctggcc agggcactgt   1380

tcatggagcc cacactgctg atgctggatg agcccaccaa ccacctggac ctcaacgctg   1440

tcatctggct taataactac ctccagggct ggcggaagac cttgctgatc gtctcccatg   1500

accagggctt cttggatgat gtctgcactg atatcatcca cctcgatgcc cagcggctcc   1560

actactatag gggcaattac atgaccttca aaaagatgta ccagcagaag cagaaagaac   1620

tgctgaaaca gtatgagaag caagagaaaa agctgaagga gctgaaggca ggcgggaagt   1680

ccaccaagca ggcggaaaaa caaacgaagg aagccctgac tcggaagcag cagaaatgcc   1740

gacggaaaaa ccaagatgag gaatcccagg aggcccctga gctcctgaag cgccctaagg   1800

agtacactgt gcgcttcact tttccagacc ccccaccact cagccctcca gtgctgggtc   1860

tgcatggtgt gacattcggc taccagggac agaaaccact ctttaagaac ttggattttg   1920

gcatcgacat ggattcaagg atttgcattg tgggccctaa tggtgtgggg aagagtacgc   1980

tactcctgct gctgactggc aagctgacac cgacccatgg ggaaatgaga aagaaccacc   2040

ggctgaaaat tggcttcttc aaccagcagt atgcagagca gctgcgcatg gaggagacgc   2100

ccactgagta cctgcagcgg ggcttcaacc tgccctacca ggatgcccgc aagtgcctgg   2160

gccgcttcgg cctggagagt cacgcccaca ccatccagat ctgcaaactc tctggtggtc   2220

agaaggcgcg agttgtgttt gctgagctgg cctgtcggga acctgatgtc ctcatcttgg   2280

acgagccaac caataacctg gacatagagt ctattgatgc tctaggggag gccatcaatg   2340

aatacaaggg tgctgtgatc gttgtcagcc atgatgcccg actcatcaca gaaaccaatt   2400

gccagctgtg ggtggtggag gagcagagtg ttagccaaat cgatggtgac tttgaagact   2460

acaagcggga ggtgttggag gccctgggtg aagtcatggt cagccggccc cgagagtgag   2520

ctttccttcc cagaagtctc ccgagagaca tatttgtgtg gcctagaagt cctctgtggt   2580

ctcccctcct ctgaagactg cctctggcct gcagctgacc tggcaaccat tcaggcacat   2640

gaaggtggag tgtgaccttg atgtgaccgg gatcccactc tgattgcatc catttctctg   2700

aaagacttgt ttgttctgct tctcttcata taactgagct ggccttatcc ttggcatccc   2760

cctaaacaaa caagaggtga ccaccttatt gtgaggttcc atccagccaa gtttatgtgg   2820

cctattgtct caggactctc atcactcaga agcctgcctc tgatttaccc tacagcttca   2880

ggcccagctg ccccccagtc tttgggtggt gctgttcttt tctggtggat ttaatgctga   2940

ctcactggta caaacagctg ttgaagctca gagctggagg tgagcttctg aggcctttgc   3000

cattatccag cccaagattt ggtgcctgca gcctcttgtc tggttgagga cttggggcag   3060

gaaaggaatg ctgctgaact tgaatttccc tttacaaggg gaagaaataa aggaaaggag   3120

ttgctgccga cctgtcactg tttggagatt gatgggagtt ggaactgttc tcagtcttga   3180

tttgctttat tcagttttct agcagctttt aatagtcccc tcttccccac taaatggatc   3240

ttgtttgcag tcttgctgac agtgtttgct gtttaaggat cataggattc ctttccccca   3300

acccttcacg caaggaaaaa gcaaagtgat tcataccttc tatcttggaa aaaaaaaaaa   3360


<210>  1429
<211>  807
<212>  PRT
<213>  Homosapiens

<400>  1429

Met Pro Lys Ala Pro Lys Gln Gln Pro Pro Glu Pro Glu Trp Ile Gly 
1               5                   10                  15      


Asp Gly Glu Ser Thr Ser Pro Ser Asp Lys Val Val Lys Lys Gly Lys 
            20                  25                  30          


Lys Asp Lys Lys Ile Lys Lys Thr Phe Phe Glu Glu Leu Ala Val Glu 
        35                  40                  45              


Asp Lys Gln Ala Gly Glu Glu Glu Lys Val Leu Lys Glu Lys Glu Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys Lys Lys Arg Asp Thr Arg 
65                  70                  75                  80  


Lys Gly Arg Arg Lys Lys Asp Val Asp Asp Asp Gly Glu Glu Lys Glu 
                85                  90                  95      


Leu Met Glu Arg Leu Lys Lys Leu Ser Val Pro Thr Ser Asp Glu Glu 
            100                 105                 110         


Asp Glu Val Pro Ala Pro Lys Pro Arg Gly Gly Lys Lys Thr Lys Gly 
        115                 120                 125             


Gly Asn Val Phe Ala Ala Leu Ile Gln Asp Gln Ser Glu Glu Glu Glu 
    130                 135                 140                 


Glu Glu Glu Lys His Pro Pro Lys Pro Ala Lys Pro Glu Lys Asn Arg 
145                 150                 155                 160 


Ile Asn Lys Ala Val Ser Glu Glu Gln Gln Pro Ala Leu Lys Gly Lys 
                165                 170                 175     


Lys Gly Lys Glu Glu Lys Ser Lys Gly Lys Ala Lys Pro Gln Asn Lys 
            180                 185                 190         


Phe Ala Ala Leu Asp Asn Glu Glu Glu Asp Lys Glu Glu Glu Ile Ile 
        195                 200                 205             


Lys Glu Lys Glu Pro Pro Lys Gln Gly Lys Glu Lys Ala Lys Lys Ala 
    210                 215                 220                 


Glu Gln Met Glu Tyr Glu Arg Gln Val Ala Ser Leu Lys Ala Ala Asn 
225                 230                 235                 240 


Ala Ala Glu Asn Asp Phe Ser Val Ser Gln Ala Glu Met Ser Ser Arg 
                245                 250                 255     


Gln Ala Met Leu Glu Asn Ala Ser Asp Ile Lys Leu Glu Lys Phe Ser 
            260                 265                 270         


Ile Ser Ala His Gly Lys Glu Leu Phe Val Asn Ala Asp Leu Tyr Ile 
        275                 280                 285             


Val Ala Gly Arg Arg Tyr Gly Leu Val Gly Pro Asn Gly Lys Gly Lys 
    290                 295                 300                 


Thr Thr Leu Leu Lys His Ile Ala Asn Arg Ala Leu Ser Ile Pro Pro 
305                 310                 315                 320 


Asn Ile Asp Val Leu Leu Cys Glu Gln Glu Val Val Ala Asp Glu Thr 
                325                 330                 335     


Pro Ala Val Gln Ala Val Leu Arg Ala Asp Thr Lys Arg Leu Lys Leu 
            340                 345                 350         


Leu Glu Glu Glu Arg Arg Leu Gln Gly Gln Leu Glu Gln Gly Asp Asp 
        355                 360                 365             


Thr Ala Ala Glu Arg Leu Glu Lys Val Tyr Glu Glu Leu Arg Ala Thr 
    370                 375                 380                 


Gly Ala Ala Ala Ala Glu Ala Lys Ala Arg Arg Ile Leu Ala Gly Leu 
385                 390                 395                 400 


Gly Phe Asp Pro Glu Met Gln Asn Arg Pro Thr Gln Lys Phe Ser Gly 
                405                 410                 415     


Gly Trp Arg Met Arg Val Ser Leu Ala Arg Ala Leu Phe Met Glu Pro 
            420                 425                 430         


Thr Leu Leu Met Leu Asp Glu Pro Thr Asn His Leu Asp Leu Asn Ala 
        435                 440                 445             


Val Ile Trp Leu Asn Asn Tyr Leu Gln Gly Trp Arg Lys Thr Leu Leu 
    450                 455                 460                 


Ile Val Ser His Asp Gln Gly Phe Leu Asp Asp Val Cys Thr Asp Ile 
465                 470                 475                 480 


Ile His Leu Asp Ala Gln Arg Leu His Tyr Tyr Arg Gly Asn Tyr Met 
                485                 490                 495     


Thr Phe Lys Lys Met Tyr Gln Gln Lys Gln Lys Glu Leu Leu Lys Gln 
            500                 505                 510         


Tyr Glu Lys Gln Glu Lys Lys Leu Lys Glu Leu Lys Ala Gly Gly Lys 
        515                 520                 525             


Ser Thr Lys Gln Ala Glu Lys Gln Thr Lys Glu Ala Leu Thr Arg Lys 
    530                 535                 540                 


Gln Gln Lys Cys Arg Arg Lys Asn Gln Asp Glu Glu Ser Gln Glu Ala 
545                 550                 555                 560 


Pro Glu Leu Leu Lys Arg Pro Lys Glu Tyr Thr Val Arg Phe Thr Phe 
                565                 570                 575     


Pro Asp Pro Pro Pro Leu Ser Pro Pro Val Leu Gly Leu His Gly Val 
            580                 585                 590         


Thr Phe Gly Tyr Gln Gly Gln Lys Pro Leu Phe Lys Asn Leu Asp Phe 
        595                 600                 605             


Gly Ile Asp Met Asp Ser Arg Ile Cys Ile Val Gly Pro Asn Gly Val 
    610                 615                 620                 


Gly Lys Ser Thr Leu Leu Leu Leu Leu Thr Gly Lys Leu Thr Pro Thr 
625                 630                 635                 640 


His Gly Glu Met Arg Lys Asn His Arg Leu Lys Ile Gly Phe Phe Asn 
                645                 650                 655     


Gln Gln Tyr Ala Glu Gln Leu Arg Met Glu Glu Thr Pro Thr Glu Tyr 
            660                 665                 670         


Leu Gln Arg Gly Phe Asn Leu Pro Tyr Gln Asp Ala Arg Lys Cys Leu 
        675                 680                 685             


Gly Arg Phe Gly Leu Glu Ser His Ala His Thr Ile Gln Ile Cys Lys 
    690                 695                 700                 


Leu Ser Gly Gly Gln Lys Ala Arg Val Val Phe Ala Glu Leu Ala Cys 
705                 710                 715                 720 


Arg Glu Pro Asp Val Leu Ile Leu Asp Glu Pro Thr Asn Asn Leu Asp 
                725                 730                 735     


Ile Glu Ser Ile Asp Ala Leu Gly Glu Ala Ile Asn Glu Tyr Lys Gly 
            740                 745                 750         


Ala Val Ile Val Val Ser His Asp Ala Arg Leu Ile Thr Glu Thr Asn 
        755                 760                 765             


Cys Gln Leu Trp Val Val Glu Glu Gln Ser Val Ser Gln Ile Asp Gly 
    770                 775                 780                 


Asp Phe Glu Asp Tyr Lys Arg Glu Val Leu Glu Ala Leu Gly Glu Val 
785                 790                 795                 800 


Met Val Ser Arg Pro Arg Glu 
                805         


<210>  1430
<211>  4540
<212>  DNA
<213>  Homosapiens

<400>  1430
attctggggt tcgtttagag gtttgaattt tctcggagaa agacaggccg gccacgagga     60

aaacagaaac aagccgcagc aacatctaag cccttgaaag gatcctgaga gaggggggaa    120

agggaaaaca gcagccacca gcccaaccac ttgtgtcttc tgccccttcc cacctatctt    180

gcccacccca ccagcccacg ctgcttggga cttgaaatct gtggccgaag gaccgtcact    240

acataacttc aaaaataatc aaccaccctc ccttcccaaa ccacccaaat tcactcatcc    300

agcgtttact tttttgaatc cactcagaac ttttttctgc gacccccctc cctaaatgga    360

gttgggtggg ggggaaatga atactgagtt ggcctttatt ttttaaaaga ctttttgatc    420

caatgaggcc ccctaaataa ttgagttttg ggtcctggtt ggttgtttta ttttttttcc    480

tccaaaattt taccccctcc cccctgagcc cgaggtgctg acgtcgcaaa aaaattggat    540

aaaaccacca tcatgggttc gggtcccata gaccccaaag aacttctcaa gggcctggac    600

agcttcctta accgagatgg ggaagtcaaa agtgtggatg ggatttccaa gatcttcagt    660

ttgatgaagg aagcacgaaa gatggtgagt cgatgcactt acttgaacat tctcctgcag    720

acccgttcac cagaaatatt ggtcaaattt attgacgttg gcggctacaa acttcttaac    780

aattggctga cgtattcaaa gacaaccaac aacattcccc tcctccagca aattctactg    840

accctgcagc atctaccgct cactgtagac catctcaagc agaacaacac agctaaactg    900

gtgaagcagc tgagcaagtc aagtgaggat gaagagctcc ggaaattggc ctcagtcctt    960

gtcagcgact ggatggctgt catccgctct cagagcagta cccagcctgc tgagaaagat   1020

aagaagaaac gtaaagatga aggaaaaagt cgaactaccc ttcctgagcg acctttgaca   1080

gaggtgaagg ctgagacccg ggctgaggag gccccagaga agaagaggga gaagcccaag   1140

tctcttcgca ccacagcacc cagtcatgcc aagttccgtt ccactggact agagctggag   1200

acaccatcct tggtgcctgt gaagaagaat gccagcacag tggtggtttc tgacaagtac   1260

aaccttaaac ccatccccct caaacgtcag agcaacgtag ctgctccagg agatgccact   1320

ccccctgcag agaagaaata caagccactc aacacaacac ctaatgccac caaagagatc   1380

aaagtgaaga tcatcccgcc acagcctatg gagggcctgg gctttctgga tgctcttaat   1440

tcagcccctg ttccaggcat caaaattaag aagaaaaaaa aagtactgtc acctacggct   1500

gccaagccaa gcccctttga agggaaaacg agcacagaac caagcacagc caaaccttct   1560

tccccagaac cagcaccacc ttctgaggca atggacgcag accgtccagg caccccggtt   1620

ccccctgttg aagtcccgga gctcatggat acagcctctt tggagccagg agctctggat   1680

gccaagccag tggagagtcc tggagatcct aaccaactga cccggaaagg caggaagagg   1740

aaaagtgtga catggcctga ggaaggcaaa ctgagagaat atttctattt tgaattggat   1800

gaaactgaac gagtaaatgt gaataagatc aaggactttg gtgaggcggc taagcgagag   1860

atactgtcag accgacatgc atttgagaca gcgcggcgtc tgagccatga taacatggag   1920

gagaaggtgc cctgggtgtg cccccggccc ctggttctgc cctcacctct tgtcacccct   1980

ggaagcaata gtcaggagcg atatatccag gctgagcggg agaagggaat ccttcaggag   2040

ctcttcctga acaaggagag tcctcatgag cctgatcctg agccctacga gcccataccc   2100

cctaaactca tccccctaga tgaggagtgt tccatggatg agactccgta tgttgagact   2160

ctggaacctg gggggtcagg tggctcacct gatggggcag gaggctccaa gttgcctcca   2220

gttctggcca atcttatggg aagcatgggt gctggaaagg gcccccaagg ccctggagga   2280

ggaggcatta atgtccaaga gatcctcacc tccatcatgg gtagcccaaa cagtcatcct   2340

tcagaggaac tactgaaaca accagactat tcggacaaga tcaagcagat gctggtgcca   2400

catggactcc taggccctgg cccaatagcc aatggtttcc caccaggggg tcctgggggc   2460

cccaagggca tgcagcactt tccccctgga cctgggggac ctatgccagg tccccatgga   2520

ggccctggtg ggccagtggg tccacgtctt ctgggtcctc caccccctcc ccggggaggt   2580

gatcccttct gggatggccc gggcgaccct atgcggggtg gcccaatgcg ggggggtcca   2640

ggaccaggtc ctggaccata ccatagaggc cgaggtggcc gaggaggaaa cgaacctcct   2700

cctcctcctc ctccattccg aggcgccaga ggaggtcgct ctggaggagg acccccaaat   2760

ggacgagggg gccctggtgg gggcatggtt ggaggtggtg ggcatcgtcc tcacgaaggc   2820

cctggtgggg gcatgggcaa cagcagtgga catcgtcccc acgaaggccc tggcggtggc   2880

atgggaagtg ggcatcgccc ccatgaaggc cctggtggta gcatgggtgg gggtggagga   2940

catcgtcccc acgaaggccc tggcggtggc atcagtggtg gcagtggcca tcgtccccat   3000

gaaggccctg gcggaggaat gggtgccggt ggtggacatc gcccccacga aggccctggc   3060

ggaagcatgg gtggaagtgg tggacatcgt ccccatgaag gccctggaca cggggggccc   3120

catggccacc ggcctcatga tgtccctggt caccgaggcc atgaccatcg agggccgcca   3180

cctcatgagc accgtggcca tgatggtcct ggccacgggg gagggggcca ccgagggcac   3240

gatggaggcc acagccatgg aggagacatg tcaaaccgcc ctgtctgccg acatttcatg   3300

atgaagggca actgccgcta tgagaacaac tgtgccttct accacccggg tgtcaatggg   3360

ccccccctgc cctagggacc atttgcctgc cctgttcaca caacccctgt ggactgcagc   3420

ctcgctcttt ccaccctgtt atggcttctg tgaggcccat tttccctttt ccccagctga   3480

tgaggagccg gccccctcag ttcccacttg cttgggttcc tgggggtttt ctgatcactg   3540

gtgcgcattg atgtacatat tttcctccag tctggggagg agagagactg gaaacgttcc   3600

tggactgctg aagaggagac ccagttggct tcactttttg agaagattcg ccctgtaccc   3660

caaacccctt tccagtatta cccttaatgc ttgagaacct aaagctggtt atcctggcga   3720

acacccctac ccttctattg cgggtcccca catgcacaca gaactctgac acaggatcag   3780

ctgcacttaa gaaatcatcc cagctaagtt cattattcct catggggtgg ggagatgctg   3840

aaaggggtat tgtatatccc actgcactga gagggctcaa tcagctggat ttgagttctg   3900

gaacacacat catccccacc cctcccccag cgtgggctca ccattcttag tcctttctca   3960

agtgggacct tcaactttct gtgaacaccc agtctgcgtc ctgggtctgc taggttcgat   4020

gatggcgaac tcgtatctgc atccggtgca agttttagct ggcagaggtg agaccggtgg   4080

tgctggtctg cctttgccaa ctatagccag tctggagact tgataaaata cttcagtgag   4140

accagcttct catcaacttg ggcccggcgt gctgggcctg aaagtcacac tacatgcact   4200

gcctttggga gtcagctcac tccctgctcc cacctggaac cttgccagcg tgaaggaggc   4260

ttccaggtac ttcaccctgt caaccacctc tgaatcccca ccaggcgcct tcctgggtgg   4320

attcaacaag atgattttgc cctttcccag ttctctcctt cactttggca tcagttgttt   4380

tctatgaaaa cagtggattg gttgggtttt gtgcagggtc ttgggttaga gccaaaatgg   4440

atttgaggat gagtattttt ttttttggtt ttgtatattt tgtacattaa taataaacag   4500

tggaaagaga agcagcttaa aaaaaaaaaa aaaaaaaaaa                         4540


<210>  1431
<211>  940
<212>  PRT
<213>  Homosapiens

<400>  1431

Met Gly Ser Gly Pro Ile Asp Pro Lys Glu Leu Leu Lys Gly Leu Asp 
1               5                   10                  15      


Ser Phe Leu Asn Arg Asp Gly Glu Val Lys Ser Val Asp Gly Ile Ser 
            20                  25                  30          


Lys Ile Phe Ser Leu Met Lys Glu Ala Arg Lys Met Val Ser Arg Cys 
        35                  40                  45              


Thr Tyr Leu Asn Ile Leu Leu Gln Thr Arg Ser Pro Glu Ile Leu Val 
    50                  55                  60                  


Lys Phe Ile Asp Val Gly Gly Tyr Lys Leu Leu Asn Asn Trp Leu Thr 
65                  70                  75                  80  


Tyr Ser Lys Thr Thr Asn Asn Ile Pro Leu Leu Gln Gln Ile Leu Leu 
                85                  90                  95      


Thr Leu Gln His Leu Pro Leu Thr Val Asp His Leu Lys Gln Asn Asn 
            100                 105                 110         


Thr Ala Lys Leu Val Lys Gln Leu Ser Lys Ser Ser Glu Asp Glu Glu 
        115                 120                 125             


Leu Arg Lys Leu Ala Ser Val Leu Val Ser Asp Trp Met Ala Val Ile 
    130                 135                 140                 


Arg Ser Gln Ser Ser Thr Gln Pro Ala Glu Lys Asp Lys Lys Lys Arg 
145                 150                 155                 160 


Lys Asp Glu Gly Lys Ser Arg Thr Thr Leu Pro Glu Arg Pro Leu Thr 
                165                 170                 175     


Glu Val Lys Ala Glu Thr Arg Ala Glu Glu Ala Pro Glu Lys Lys Arg 
            180                 185                 190         


Glu Lys Pro Lys Ser Leu Arg Thr Thr Ala Pro Ser His Ala Lys Phe 
        195                 200                 205             


Arg Ser Thr Gly Leu Glu Leu Glu Thr Pro Ser Leu Val Pro Val Lys 
    210                 215                 220                 


Lys Asn Ala Ser Thr Val Val Val Ser Asp Lys Tyr Asn Leu Lys Pro 
225                 230                 235                 240 


Ile Pro Leu Lys Arg Gln Ser Asn Val Ala Ala Pro Gly Asp Ala Thr 
                245                 250                 255     


Pro Pro Ala Glu Lys Lys Tyr Lys Pro Leu Asn Thr Thr Pro Asn Ala 
            260                 265                 270         


Thr Lys Glu Ile Lys Val Lys Ile Ile Pro Pro Gln Pro Met Glu Gly 
        275                 280                 285             


Leu Gly Phe Leu Asp Ala Leu Asn Ser Ala Pro Val Pro Gly Ile Lys 
    290                 295                 300                 


Ile Lys Lys Lys Lys Lys Val Leu Ser Pro Thr Ala Ala Lys Pro Ser 
305                 310                 315                 320 


Pro Phe Glu Gly Lys Thr Ser Thr Glu Pro Ser Thr Ala Lys Pro Ser 
                325                 330                 335     


Ser Pro Glu Pro Ala Pro Pro Ser Glu Ala Met Asp Ala Asp Arg Pro 
            340                 345                 350         


Gly Thr Pro Val Pro Pro Val Glu Val Pro Glu Leu Met Asp Thr Ala 
        355                 360                 365             


Ser Leu Glu Pro Gly Ala Leu Asp Ala Lys Pro Val Glu Ser Pro Gly 
    370                 375                 380                 


Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val Thr 
385                 390                 395                 400 


Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu Asp 
                405                 410                 415     


Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu Ala 
            420                 425                 430         


Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala Arg 
        435                 440                 445             


Arg Leu Ser His Asp Asn Met Glu Glu Lys Val Pro Trp Val Cys Pro 
    450                 455                 460                 


Arg Pro Leu Val Leu Pro Ser Pro Leu Val Thr Pro Gly Ser Asn Ser 
465                 470                 475                 480 


Gln Glu Arg Tyr Ile Gln Ala Glu Arg Glu Lys Gly Ile Leu Gln Glu 
                485                 490                 495     


Leu Phe Leu Asn Lys Glu Ser Pro His Glu Pro Asp Pro Glu Pro Tyr 
            500                 505                 510         


Glu Pro Ile Pro Pro Lys Leu Ile Pro Leu Asp Glu Glu Cys Ser Met 
        515                 520                 525             


Asp Glu Thr Pro Tyr Val Glu Thr Leu Glu Pro Gly Gly Ser Gly Gly 
    530                 535                 540                 


Ser Pro Asp Gly Ala Gly Gly Ser Lys Leu Pro Pro Val Leu Ala Asn 
545                 550                 555                 560 


Leu Met Gly Ser Met Gly Ala Gly Lys Gly Pro Gln Gly Pro Gly Gly 
                565                 570                 575     


Gly Gly Ile Asn Val Gln Glu Ile Leu Thr Ser Ile Met Gly Ser Pro 
            580                 585                 590         


Asn Ser His Pro Ser Glu Glu Leu Leu Lys Gln Pro Asp Tyr Ser Asp 
        595                 600                 605             


Lys Ile Lys Gln Met Leu Val Pro His Gly Leu Leu Gly Pro Gly Pro 
    610                 615                 620                 


Ile Ala Asn Gly Phe Pro Pro Gly Gly Pro Gly Gly Pro Lys Gly Met 
625                 630                 635                 640 


Gln His Phe Pro Pro Gly Pro Gly Gly Pro Met Pro Gly Pro His Gly 
                645                 650                 655     


Gly Pro Gly Gly Pro Val Gly Pro Arg Leu Leu Gly Pro Pro Pro Pro 
            660                 665                 670         


Pro Arg Gly Gly Asp Pro Phe Trp Asp Gly Pro Gly Asp Pro Met Arg 
        675                 680                 685             


Gly Gly Pro Met Arg Gly Gly Pro Gly Pro Gly Pro Gly Pro Tyr His 
    690                 695                 700                 


Arg Gly Arg Gly Gly Arg Gly Gly Asn Glu Pro Pro Pro Pro Pro Pro 
705                 710                 715                 720 


Pro Phe Arg Gly Ala Arg Gly Gly Arg Ser Gly Gly Gly Pro Pro Asn 
                725                 730                 735     


Gly Arg Gly Gly Pro Gly Gly Gly Met Val Gly Gly Gly Gly His Arg 
            740                 745                 750         


Pro His Glu Gly Pro Gly Gly Gly Met Gly Asn Ser Ser Gly His Arg 
        755                 760                 765             


Pro His Glu Gly Pro Gly Gly Gly Met Gly Ser Gly His Arg Pro His 
    770                 775                 780                 


Glu Gly Pro Gly Gly Ser Met Gly Gly Gly Gly Gly His Arg Pro His 
785                 790                 795                 800 


Glu Gly Pro Gly Gly Gly Ile Ser Gly Gly Ser Gly His Arg Pro His 
                805                 810                 815     


Glu Gly Pro Gly Gly Gly Met Gly Ala Gly Gly Gly His Arg Pro His 
            820                 825                 830         


Glu Gly Pro Gly Gly Ser Met Gly Gly Ser Gly Gly His Arg Pro His 
        835                 840                 845             


Glu Gly Pro Gly His Gly Gly Pro His Gly His Arg Pro His Asp Val 
    850                 855                 860                 


Pro Gly His Arg Gly His Asp His Arg Gly Pro Pro Pro His Glu His 
865                 870                 875                 880 


Arg Gly His Asp Gly Pro Gly His Gly Gly Gly Gly His Arg Gly His 
                885                 890                 895     


Asp Gly Gly His Ser His Gly Gly Asp Met Ser Asn Arg Pro Val Cys 
            900                 905                 910         


Arg His Phe Met Met Lys Gly Asn Cys Arg Tyr Glu Asn Asn Cys Ala 
        915                 920                 925             


Phe Tyr His Pro Gly Val Asn Gly Pro Pro Leu Pro 
    930                 935                 940 


<210>  1432
<211>  1439
<212>  DNA
<213>  Homosapiens

<400>  1432
gcctttccgt caattcctgt cctgggcgta cgtcaagatg gcggcgtctg tattaaacac     60

cgtgctgagg cggcttccta tgctatctct cttccgaggt tctcacagag ttcaggttcc    120

cctccagact ctttgcacca aagctccctc tgaggaagat tctttgtcct cagttcccat    180

ttctccttat aaggatgagc cctggaaata tctggaatca gaagaatacc aggagcgata    240

tggttctcgc cccgtctggg ctgactaccg ccgcaaccac aagggtggtg tacccccaca    300

gcggactcgg aagacatgta ttcgtcggaa taaagttgtt gggaatccct gccccatctg    360

tcgagatcac aagttgcatg ttgactttag gaacgtgaag ctcttggagc aatttgtctg    420

cgcccacacg ggtatcatct tctatgctcc atacacagga gtctgtgtga agcagcacaa    480

gcggttgacc caggccatcc agaaagccag ggatcatggt ctcctcattt accacatccc    540

ccaggttgaa ccacgggacc ttgacttcag tacctctcat ggggctgtga gtgctactcc    600

gccagccccc accctggtct caggtgaccc ctggtaccca tggtacaact ggaaacagcc    660

accggagaga gaactgtctc gccttcgccg gctttaccag ggtcatctcc aagaagagag    720

tggcccccca cctgagtcaa tgcccaagat gccccctaga acaccagcgg aagcctcctc    780

cactgggcag acaggccctc agagtgctct gtaggagctg tagactggga agagaggcca    840

ggcgtggtgg ctcactcctg taatcccagc actttgggaa gccaaggtgg gctgatcact    900

tgatcccagg agtttgagac cagcctgggc accatggtga aacctcgtct ttaccaaaaa    960

atacaaaaat tagctgggtg tggtggtgca cacctgtagt ctcaactatt ggggaggcta   1020

aggtaggatc acttgatccc aggaggcgga ggttgcagtg agttgcagtc acacccctgc   1080

actccagcct gggtgacagc tagaccctgt ctcaaaaaaa aaaaaaaaga ctgggaagag   1140

agctagaggg actaggagat aatgtgtatg taggtttatg tgatgggata tcaccctgaa   1200

gagttgtgtc ttttgtggcc agtgacaaat ccaggaaatg aatgttgctg atagggataa   1260

atcttgaggc tgagggcggg tggtacagat gtgtatggga aaccccaacc cctatatatt   1320

gtaaatagat gggctgggct aaacattgtt gccgtttcat acttctacca actcagcttt   1380

tacacaataa agctctactg tctctgggta aaaaaaaaaa aaaaaaaaaa aaaaaaaaa    1439


<210>  1433
<211>  258
<212>  PRT
<213>  Homosapiens

<400>  1433

Met Ala Ala Ser Val Leu Asn Thr Val Leu Arg Arg Leu Pro Met Leu 
1               5                   10                  15      


Ser Leu Phe Arg Gly Ser His Arg Val Gln Val Pro Leu Gln Thr Leu 
            20                  25                  30          


Cys Thr Lys Ala Pro Ser Glu Glu Asp Ser Leu Ser Ser Val Pro Ile 
        35                  40                  45              


Ser Pro Tyr Lys Asp Glu Pro Trp Lys Tyr Leu Glu Ser Glu Glu Tyr 
    50                  55                  60                  


Gln Glu Arg Tyr Gly Ser Arg Pro Val Trp Ala Asp Tyr Arg Arg Asn 
65                  70                  75                  80  


His Lys Gly Gly Val Pro Pro Gln Arg Thr Arg Lys Thr Cys Ile Arg 
                85                  90                  95      


Arg Asn Lys Val Val Gly Asn Pro Cys Pro Ile Cys Arg Asp His Lys 
            100                 105                 110         


Leu His Val Asp Phe Arg Asn Val Lys Leu Leu Glu Gln Phe Val Cys 
        115                 120                 125             


Ala His Thr Gly Ile Ile Phe Tyr Ala Pro Tyr Thr Gly Val Cys Val 
    130                 135                 140                 


Lys Gln His Lys Arg Leu Thr Gln Ala Ile Gln Lys Ala Arg Asp His 
145                 150                 155                 160 


Gly Leu Leu Ile Tyr His Ile Pro Gln Val Glu Pro Arg Asp Leu Asp 
                165                 170                 175     


Phe Ser Thr Ser His Gly Ala Val Ser Ala Thr Pro Pro Ala Pro Thr 
            180                 185                 190         


Leu Val Ser Gly Asp Pro Trp Tyr Pro Trp Tyr Asn Trp Lys Gln Pro 
        195                 200                 205             


Pro Glu Arg Glu Leu Ser Arg Leu Arg Arg Leu Tyr Gln Gly His Leu 
    210                 215                 220                 


Gln Glu Glu Ser Gly Pro Pro Pro Glu Ser Met Pro Lys Met Pro Pro 
225                 230                 235                 240 


Arg Thr Pro Ala Glu Ala Ser Ser Thr Gly Gln Thr Gly Pro Gln Ser 
                245                 250                 255     


Ala Leu 
        


<210>  1434
<211>  1740
<212>  DNA
<213>  Homosapiens

<400>  1434
atggagttcc cgttcgatgt ggacgcgctg ttcccggagc ggatcacggt gctggaccag     60

cacctgaggc ccccagcccg ccgacccgga accacaacgc cggcccggtg acagctcaaa    120

cccaccctct ggcccttttc tcccggttcc tcttcaaacc tggtccaggc accacgcccc    180

cttctcactg actagtgatc gccccttttg atgtccaggc ctgccttttt ggtgacctct    240

gaccctgggc ctagtgggat tgatcagcgc ttggatctgt gacctttcac cccgggccca    300

aaatgtccca atcaaaggat gtggttgacc tggcctttct gcttcctcac aataacctta    360

agggaggagg gagtgtgcca ccttgaaagt gttgatctac agcagcaaat tatgaccatt    420

atagatgaac tgggcaaggc ttctgccaag gcccagaatc tttccgctcc tatcactagt    480

gcatcaagga tgcagagtaa ccgccatgtt gtttatattc tcaaagacag ttcagcccga    540

ccggctggaa aaggagccat tattggtttc atcaaagttg gatacaagaa gctctttgta    600

ctggatgatc gtgaggctca taatgaggta gaaccacttt gcatcctgga cttttacatc    660

catgagtctg tgcaacgcca tggccatggg cgagaactct tccagtatat gttgcagaag    720

gagcgagtgg aaccgcacca actggcaatt gaccgaccct cacagaagct gctgaaattc    780

ctgaataagc actacaatct ggagaccaca gtcccacagg tgaacaactt tgtgatcttt    840

gaaggcttct ttgcccatca acatcggccc cctgctccct ctctgagggc aactcgacac    900

tctcgtgctg ctgcagtcga tcccacgccc gctgctccag caaggaagct gccacccaag    960

agagcagagg gagacatcaa gccatactcc tctagtgacc gagaatttct gaaggtagct   1020

gtggagcctc cttggcccct aaacagggcc cctcgccgcg ccacacctcc agcccaccca   1080

cccccccgct ccagcagcct gggaaactca ccagaacgag gtcccctccg cccctttgtg   1140

ccagagcagg agctgctgcg ttccttgcgc ctctgccccc cacaccctac cgcccgcctt   1200

ctgttggctg ctgaccctgg gggcagccca gctcaacgtc gtcgcaccag ggggactccc   1260

ccaggtctgg tagcccaaag ctgctgctac agccgccatg ggggggtgaa ttcctcatcc   1320

cccaatacag gcaaccaaga ctccaagcag ggagaacagg aaacaaagaa taggtctgcc   1380

agtgaggagc aggccttgtc acaggatggg tctggggaga agcccatgca cacagctcct   1440

ccacaggccc cggccccgcc agcccagtcc tggacagtgg gtggggacat actcaacgcc   1500

aggttcattc gaaacctgca ggaacgtcgc agcaccaggc cttggtgacc gcagccccgt   1560

caaacatctt caaagtatta tttctccctc actacaggaa agagccaaag cccaaccctc   1620

ataatagatg gatacattca ttcattcatt cattcagcag gcttatcaga ttcaagtcat   1680

ttgtatcttt taaccagacc aataaaagta tttattttta tcacaaaaaa aaaaaaaaaa   1740


<210>  1435
<211>  409
<212>  PRT
<213>  Homosapiens

<400>  1435

Met Trp Leu Thr Trp Pro Phe Cys Phe Leu Thr Ile Thr Leu Arg Glu 
1               5                   10                  15      


Glu Gly Val Cys His Leu Glu Ser Val Asp Leu Gln Gln Gln Ile Met 
            20                  25                  30          


Thr Ile Ile Asp Glu Leu Gly Lys Ala Ser Ala Lys Ala Gln Asn Leu 
        35                  40                  45              


Ser Ala Pro Ile Thr Ser Ala Ser Arg Met Gln Ser Asn Arg His Val 
    50                  55                  60                  


Val Tyr Ile Leu Lys Asp Ser Ser Ala Arg Pro Ala Gly Lys Gly Ala 
65                  70                  75                  80  


Ile Ile Gly Phe Ile Lys Val Gly Tyr Lys Lys Leu Phe Val Leu Asp 
                85                  90                  95      


Asp Arg Glu Ala His Asn Glu Val Glu Pro Leu Cys Ile Leu Asp Phe 
            100                 105                 110         


Tyr Ile His Glu Ser Val Gln Arg His Gly His Gly Arg Glu Leu Phe 
        115                 120                 125             


Gln Tyr Met Leu Gln Lys Glu Arg Val Glu Pro His Gln Leu Ala Ile 
    130                 135                 140                 


Asp Arg Pro Ser Gln Lys Leu Leu Lys Phe Leu Asn Lys His Tyr Asn 
145                 150                 155                 160 


Leu Glu Thr Thr Val Pro Gln Val Asn Asn Phe Val Ile Phe Glu Gly 
                165                 170                 175     


Phe Phe Ala His Gln His Arg Pro Pro Ala Pro Ser Leu Arg Ala Thr 
            180                 185                 190         


Arg His Ser Arg Ala Ala Ala Val Asp Pro Thr Pro Ala Ala Pro Ala 
        195                 200                 205             


Arg Lys Leu Pro Pro Lys Arg Ala Glu Gly Asp Ile Lys Pro Tyr Ser 
    210                 215                 220                 


Ser Ser Asp Arg Glu Phe Leu Lys Val Ala Val Glu Pro Pro Trp Pro 
225                 230                 235                 240 


Leu Asn Arg Ala Pro Arg Arg Ala Thr Pro Pro Ala His Pro Pro Pro 
                245                 250                 255     


Arg Ser Ser Ser Leu Gly Asn Ser Pro Glu Arg Gly Pro Leu Arg Pro 
            260                 265                 270         


Phe Val Pro Glu Gln Glu Leu Leu Arg Ser Leu Arg Leu Cys Pro Pro 
        275                 280                 285             


His Pro Thr Ala Arg Leu Leu Leu Ala Ala Asp Pro Gly Gly Ser Pro 
    290                 295                 300                 


Ala Gln Arg Arg Arg Thr Arg Gly Thr Pro Pro Gly Leu Val Ala Gln 
305                 310                 315                 320 


Ser Cys Cys Tyr Ser Arg His Gly Gly Val Asn Ser Ser Ser Pro Asn 
                325                 330                 335     


Thr Gly Asn Gln Asp Ser Lys Gln Gly Glu Gln Glu Thr Lys Asn Arg 
            340                 345                 350         


Ser Ala Ser Glu Glu Gln Ala Leu Ser Gln Asp Gly Ser Gly Glu Lys 
        355                 360                 365             


Pro Met His Thr Ala Pro Pro Gln Ala Pro Ala Pro Pro Ala Gln Ser 
    370                 375                 380                 


Trp Thr Val Gly Gly Asp Ile Leu Asn Ala Arg Phe Ile Arg Asn Leu 
385                 390                 395                 400 


Gln Glu Arg Arg Ser Thr Arg Pro Trp 
                405                 


<210>  1436
<211>  2636
<212>  DNA
<213>  Homosapiens

<400>  1436
acagtgggcc atggagttcc cgttcgatgt ggacgcgctg ttcccggagc ggatcacggt     60

gctggaccag cacctgaggc ccccagcccg ccgacccgga accacaacgc cggcccgtgt    120

tgatctacag cagcaaatta tgaccattat agatgaactg ggcaaggctt ctgccaaggc    180

ccagaatctt tccgctccta tcactagtgc atcaaggatg cagagtaacc gccatgttgt    240

ttatattctc aaggacagtt cagcccgacc ggctggaaaa ggagccatta ttggtttcat    300

caaagttgga tacaagaagc tctttgtact ggatgatcgt gaggctcata atgaggtaga    360

accactttgc atcctggact tttacatcca tgagtctgtg caacgccatg gccatgggcg    420

agaactcttc cagtatatgt tgcagaagga gcgagtggaa ccgcaccaac tggcaattga    480

ccgaccctct cagaagctgc tgaaattcct gaataagcac tacaatctgg agaccacagt    540

cccacaggtg aacaactttg tgatctttga aggcttcttt gcccatcaac atcggccccc    600

tgctccctct ctgagggcaa ctcgacactc tcgtgctgct gcagtcgatc ccacgcccgc    660

tgctccagca aggaagctgc cacccaagag agcagaggga gacatcaagc catactcctc    720

tagtgaccga gaatttctga aggtagctgt ggagcctcct tggcccctaa acagggcccc    780

tcgccgcgcc acacctccag cccacccacc cccccgctcc agcagcctgg gaaactcacc    840

agaacgaggt cccctccgcc cctttgtgcc agagcaggag ctgctgcgtt ccttgcgcct    900

ctgcccccca caccctaccg cccgccttct gttggctgct gaccctgggg gcagcccagc    960

tcaacgtcgt cgcaccaggt aataggagtt gaagggctaa ggagcctcac agctataaaa   1020

gaggatgtta gaaatggcaa agggcaattt gaatccatca gagagatgga tcaataagat   1080

gggtggcttg gggggggtcc tgaaaccttt caagaaaaat atttgtgcaa gtgatctggg   1140

aaaaaaatgc agtgaaggag cagaatagga ccttatatgg agcctaggga ccctggcttt   1200

aatgtgagag ttatgtggaa tggtaggaag aacaccgaga tccatcgagt tgggggaaca   1260

gagccttcta agattgggaa aatcttcgct taatacttgc tggggaaggg gcagtgtctg   1320

acagagagtg ggaagccact ggcttgtgtg ccaagagtcc atcgcagcag gcagggagtg   1380

ggcatttcct ttatttctct ccctttctct tcacctctga cttctctgtt tttctctccc   1440

ccgccccccg ccatttccca tctcccttcc tcccatccat aacatccttc cacagctccc   1500

ttccccgctc tgaggagagt cgatactaac agctacccta tccctgccct gggagacctg   1560

gggtgggcag ggaacccctc cctgaggacc tcagaccctc tcttccattg catcctgtag   1620

gacccagtgg aacctgacag agcccatagg attccctctt ctactttctt agacagcagg   1680

gatgtcaggg tctcaaactg cctaacactt tgtagctttt cttaacacaa aagcacccct   1740

tctctcctaa cttgggctct gaatactttc ccaacaggaa gtctgatctg ttgccagact   1800

tcttggttag atggctcata catttatcta gagaagcaca ctcttgcttg ctgtcaaact   1860

ttagaacacc atggaaggtc taagggcatc ctgtgccagg gaaacttttt aaggaatttt   1920

atctatggga taaaccccat attccctcta gtgtctactg gtggctctaa tactgctttg   1980

tgctgcctgc cacacttgcc ctttgagcct gcgaatggcc gctagtgagc aagctctgct   2040

tcagagcagt ctagttaggt agaacaggga cttaccagct tcccaaaggg atctactcac   2100

cattgccaaa ctcttcattt ccacattttg tgtaggtgtc agggaacccc aaactggtgt   2160

tgctttgggg tctctaaagg agattggctg acaccaccat ttcccccaga tcctgattct   2220

ctgggggagg ttgtttcttg agagtagatc cagagtgtca aggatctgtt agatcctgga   2280

atcccttctt gcatccatcc ctccctggta gctaggtccc gatatactcc tgtcttgtga   2340

gattgtcgag atgagatggg ggaccactct tcctctgtcc ttcctctctc ctttcctcca   2400

tagcaaggac gaccttccct gctccatgcc cagagtatag ctagatccct tcccctccct   2460

accctctgaa tgtgtgctag atcaggtgcc ccactgtgtt tcctgaaatc cttgggagcc   2520

ggatctcccc atctccccta ctcactcttc ccttttcttc tctcagtgtt gtctgaataa   2580

agtgtgaaat cttttgtgtt ttctaaattg acattttcaa tgaaaaaaag aatcac       2636


<210>  1437
<211>  323
<212>  PRT
<213>  Homosapiens

<400>  1437

Met Glu Phe Pro Phe Asp Val Asp Ala Leu Phe Pro Glu Arg Ile Thr 
1               5                   10                  15      


Val Leu Asp Gln His Leu Arg Pro Pro Ala Arg Arg Pro Gly Thr Thr 
            20                  25                  30          


Thr Pro Ala Arg Val Asp Leu Gln Gln Gln Ile Met Thr Ile Ile Asp 
        35                  40                  45              


Glu Leu Gly Lys Ala Ser Ala Lys Ala Gln Asn Leu Ser Ala Pro Ile 
    50                  55                  60                  


Thr Ser Ala Ser Arg Met Gln Ser Asn Arg His Val Val Tyr Ile Leu 
65                  70                  75                  80  


Lys Asp Ser Ser Ala Arg Pro Ala Gly Lys Gly Ala Ile Ile Gly Phe 
                85                  90                  95      


Ile Lys Val Gly Tyr Lys Lys Leu Phe Val Leu Asp Asp Arg Glu Ala 
            100                 105                 110         


His Asn Glu Val Glu Pro Leu Cys Ile Leu Asp Phe Tyr Ile His Glu 
        115                 120                 125             


Ser Val Gln Arg His Gly His Gly Arg Glu Leu Phe Gln Tyr Met Leu 
    130                 135                 140                 


Gln Lys Glu Arg Val Glu Pro His Gln Leu Ala Ile Asp Arg Pro Ser 
145                 150                 155                 160 


Gln Lys Leu Leu Lys Phe Leu Asn Lys His Tyr Asn Leu Glu Thr Thr 
                165                 170                 175     


Val Pro Gln Val Asn Asn Phe Val Ile Phe Glu Gly Phe Phe Ala His 
            180                 185                 190         


Gln His Arg Pro Pro Ala Pro Ser Leu Arg Ala Thr Arg His Ser Arg 
        195                 200                 205             


Ala Ala Ala Val Asp Pro Thr Pro Ala Ala Pro Ala Arg Lys Leu Pro 
    210                 215                 220                 


Pro Lys Arg Ala Glu Gly Asp Ile Lys Pro Tyr Ser Ser Ser Asp Arg 
225                 230                 235                 240 


Glu Phe Leu Lys Val Ala Val Glu Pro Pro Trp Pro Leu Asn Arg Ala 
                245                 250                 255     


Pro Arg Arg Ala Thr Pro Pro Ala His Pro Pro Pro Arg Ser Ser Ser 
            260                 265                 270         


Leu Gly Asn Ser Pro Glu Arg Gly Pro Leu Arg Pro Phe Val Pro Glu 
        275                 280                 285             


Gln Glu Leu Leu Arg Ser Leu Arg Leu Cys Pro Pro His Pro Thr Ala 
    290                 295                 300                 


Arg Leu Leu Leu Ala Ala Asp Pro Gly Gly Ser Pro Ala Gln Arg Arg 
305                 310                 315                 320 


Arg Thr Arg 
            


<210>  1438
<211>  1496
<212>  DNA
<213>  Homosapiens

<400>  1438
gtgccctgca gcgcgtggac aggctagggg tcgcgggagc gggagggagg cgctgccggg     60

cctgtcgcgc aaggacgtcg gtcctcccag gtttgagggc ggtcaggcgg ggtcaaggcc    120

aggcagcggg gcgcgtctgc gttgcgcccg actctccgcg gttacctgtg cctagaggtg    180

atttgaaggg caggggccga gagattcgta gccctgctgc ggcgccgtcc cggagttccc    240

cggcccagac cagacccgcg gggcgccctc agcagcccgc ccgtcttgca ctcggagagc    300

ggtcctggca ggaaggccgg ccagtgtgca cccggttcgg gcccctgcgc ccgggctggc    360

aagatggcca cgcccccagc agagacggcg cctctaggac accatcgggg accgaggacc    420

agctttatcc agggactcta ccattcccac ccctttggcc ccactccacg acaaccactt    480

ccccatcttc tcctctattc tggtctcccc tgcccccacg ccttcccacc cagcgtcttc    540

cccaggttcc cccactacct ctccctcaga tccaggccct cagctcagca tgggtggttc    600

tccctccagg aaagggggag gagggaccag gacctgagtt gcatagcggc tgcctggatg    660

ggcttagaag cctttttgag ggacctccct gcccctatcc tggggcttgg atacctttcc    720

aagtccctgg aactgcccac ccttcccctg ccaccccgtc aggagatcct agtatggagg    780

aacatctgtc tgtcatgtat gagagactga gacaagagct tcccaagctc ttccttcagt    840

cccacgacta cagtctgtat tccttggatg tggaattcat caatgagatc ctcaacatac    900

gtaccaaggg ccggacatgg tacattcttt cactgaccct ctgccgtttc ctggcctgga    960

attattttgc acaccttcgt ttggaggttt tacagctgac ccgccaccct gagaactgga   1020

ccctgcaagc ccggtggcgg cttgtggggc tgcccgtcca cttgctcttt ttgcggttct   1080

acaagcgtga caaagacgag cattaccgga cctatgatgc ctactccact ttctacctga   1140

attccagtgg cctcatttgt cgccatcgtc tagataaact gatgccttca cactcacctc   1200

caacgcctgt gaagaagctg ctagtgggag ccctggtggc cctggggctg tcagagccag   1260

aacctgactt aaacctgtgt tccaagccct gatccttgac cttggagtgg aggcagcact   1320

gaagactgct acgcccaaga gaaggaggtg gaggcagcca agaatctcag gagccagctt   1380

cctctcctcg tttctctcct tccttccttt ccatctcatg ctgtgtaaag ctgctgtgta   1440

atttaacttg taaataataa agtttaactg actatatgaa aaaaaaaaaa aaaaaa       1496


<210>  1439
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  1439

Met Glu Glu His Leu Ser Val Met Tyr Glu Arg Leu Arg Gln Glu Leu 
1               5                   10                  15      


Pro Lys Leu Phe Leu Gln Ser His Asp Tyr Ser Leu Tyr Ser Leu Asp 
            20                  25                  30          


Val Glu Phe Ile Asn Glu Ile Leu Asn Ile Arg Thr Lys Gly Arg Thr 
        35                  40                  45              


Trp Tyr Ile Leu Ser Leu Thr Leu Cys Arg Phe Leu Ala Trp Asn Tyr 
    50                  55                  60                  


Phe Ala His Leu Arg Leu Glu Val Leu Gln Leu Thr Arg His Pro Glu 
65                  70                  75                  80  


Asn Trp Thr Leu Gln Ala Arg Trp Arg Leu Val Gly Leu Pro Val His 
                85                  90                  95      


Leu Leu Phe Leu Arg Phe Tyr Lys Arg Asp Lys Asp Glu His Tyr Arg 
            100                 105                 110         


Thr Tyr Asp Ala Tyr Ser Thr Phe Tyr Leu Asn Ser Ser Gly Leu Ile 
        115                 120                 125             


Cys Arg His Arg Leu Asp Lys Leu Met Pro Ser His Ser Pro Pro Thr 
    130                 135                 140                 


Pro Val Lys Lys Leu Leu Val Gly Ala Leu Val Ala Leu Gly Leu Ser 
145                 150                 155                 160 


Glu Pro Glu Pro Asp Leu Asn Leu Cys Ser Lys Pro 
                165                 170         


<210>  1440
<211>  3377
<212>  DNA
<213>  Homosapiens

<400>  1440
gtcggaagat cctagaggtc ccaaggtagc tgacctgcga agctgaggct ccagccgagg     60

gctccaggcc tctgaccggc ccagcagtga gcgcggctgc ccgacgcttc agggccggga    120

gcagggagcg tgagtcgcca tggcgacgcc ggcgggtctg gagcgctggg ttcaggacga    180

gctgcactcg gtgttggggc tgagcgagcg gcacgtcgcc cagtttctga tcggtaccgc    240

acagcgctgc acctctgccg aggagttcgt gcagcgccta cgagacactg ataccttgga    300

tctcagtggg ccggcccggg acttcgccct gagactctgg aacaaggtac cacgaaaggc    360

agtggtagaa aagccagctc gggcagcaga gcgagaggcc cgggccctgc tggagaagaa    420

ccgatcttat aggttactgg aagacagtga agagagcagt gaggagactg tgagtagggc    480

tggaagcagc ctccagaaga aacgtaaaaa gcggaaacac ctcaggaaga agcgtgagga    540

agaagaggag gaagaggctt ctgagaaagg gaagaagaaa acagggggga gtaaacagca    600

gacagagaag ccagagtcgg aagatgagtg ggaacggaca gagcgtgaac gccttcagga    660

cctggaggag cgtgatgcct ttgctgagcg ggttcgacag cgggacaagg atcggactcg    720

aaatgtcctg gaacggtcag acaagaaggc ttatgaagag gctcagaagc gcctcaagat    780

ggccgaggaa gaccggaagg ccatgatccc tgagctgcgg aagaaatctc gccgagagta    840

cctggctaag cgggagcgag agaagcttga ggacctggag gcggagctgg ctgatgagga    900

gttccttttt ggggacgtgg agctgagccg gcacgagcgg caggagctca aatataagcg    960

gcgagtgcgg gatctcgccc gggagtaccg ggcagctggg gagcaggaga agctggaggc   1020

caccaatcgc taccacatgc ccaaggaaac ccgaggacag ccagcccgag ctgtggatct   1080

agtggaggag gaatcaggag cccctgggga ggagcagcgg cgctgggagg aggcgcggct   1140

tggggcagcg tccctgaagt ttggggcccg agatgctgcc tctcaggagc ccaagtatca   1200

actggtgctg gaggaggagg agaccattga gtttgtccgg gccactcagc tccagggtga   1260

tgaggagccg tcagctccac ccacttcaac tcaggcccag cagaaagagt ccatccaggc   1320

cgtccgccgc agcctcccgg tgttcccatt tcgagaggag ctcctggctg ctattgcaaa   1380

tcaccaagtc ctcatcattg aaggcgagac aggctcaggg aagaccaccc agatcccgca   1440

gtatctcttt gaggagggtt atacaaacaa gggtatgaag attgcctgca cccaaccccg   1500

gagagtggct gccatgagtg tggccgcccg agtggcccgg gagatgggtg tgaagcttgg   1560

gaatgaggtt ggctacagca tccgctttga ggactgcaca tcagagcgaa ctgtcctccg   1620

ctacatgaca gatgggatgc ttctccggga gttcctctct gagcctgacc tggcgagtta   1680

cagcgtggtg atggtggatg aggcacacga aaggacccta cacacagaca ttctctttgg   1740

attgatcaag gatgttgctc gcttccgacc tgagctcaag gtcctggtgg cttcagccac   1800

aatggacact gcccgttttt ccaccttctt tgatgacgcc cctgtgtttc gaatccccgg   1860

acgcaggttt cctgtggaca tcttctacac caaggctcca gaggctgact acttggaagc   1920

ttgtgtagta tctgtgttgc agatccatgt gacccagccc cctggggata tcctggtgtt   1980

cctgacagga caggaggaga ttgaggctgc ctgtgagatg ctccaggatc cctgccgccg   2040

cctgggctcc aaaatccggg agctcctggt gctgcccatt tatgccaatc tgccctctga   2100

catgcaggcc cgtatcttcc agcccacacc acctggggca cgaaaggtgg ttgtggcaac   2160

gaacattgct gagacatcac ccaccattga gggcatcatt tatgtgctgg atccagggtt   2220

ctgtaagcag aagagctaca acccccgcac aggcatggaa tcgctcactg tcacaccctg   2280

cagcaaggcc tcagccaatc agcgagctgg cagggcaggt cgggtggctg cagggaagtg   2340

cttccgcctg tataccgcct gggcctatca gcacgagctt gaggaaacca cagtgcctga   2400

gatccagagg accagcttgg gcaatgtcgt gttgctgctc aagagcttag ggatccatga   2460

cctaatgcac tttgatttcc tggaccctcc accatatgag acactgctgc tgactttgga   2520

gcagctgtat gctctgggag ccctcaacca ccttggggag ctcaccacgt ctggtcgaaa   2580

gatggcagag ctgccggtgg accccatgct gtccaaaatg atcttagcct ctgagaagta   2640

cagctgttca gaggagatcc tgacagtggc tgccatgctc tctgtcaaca actccatctt   2700

ctaccgacca aaggacaagg tcgtccatgc tgacaatgcc cgtgtcaact tctttctccc   2760

tggcggtgac cacctggttc tgctaaatgt ttacacacag tgggctgaga gtggttactc   2820

ttcccagtgg tgctgtgaga actttgtaca gttcagatcg atgcgccgag cccgggatgt   2880

gcgggaacag ctggaagggc tcttggaacg tgtggaagtt ggtctcagtt cctgccaggg   2940

ggactatatc cgtgtacgca aggccatcac tgctggttac ttttaccaca cggcacggtt   3000

gactcggagt ggctaccgca cagtgaaaca gcagcagaca gtcttcattc atcccaactc   3060

ctccctcttt gagcaacagc cacgctggct gctctaccac gaacttgtct tgaccaccaa   3120

agagttcatg agacaggtac tggagattga gagcagttgg cttctggagg tggctcccca   3180

ttattataag gccaaggagc tagaagatcc ccatgctaag aaaatgccca aaaaaatagg   3240

caaaacacga gaagagctag ggtaagagaa ggacgcaaac agaacctgac accagctcct   3300

tttccttcta tacattattt aatacctatt aaataatatt atttttggaa taaagcttgt   3360

gggaacattt gggatct                                                  3377


<210>  1441
<211>  1041
<212>  PRT
<213>  Homosapiens

<400>  1441

Met Ala Thr Pro Ala Gly Leu Glu Arg Trp Val Gln Asp Glu Leu His 
1               5                   10                  15      


Ser Val Leu Gly Leu Ser Glu Arg His Val Ala Gln Phe Leu Ile Gly 
            20                  25                  30          


Thr Ala Gln Arg Cys Thr Ser Ala Glu Glu Phe Val Gln Arg Leu Arg 
        35                  40                  45              


Asp Thr Asp Thr Leu Asp Leu Ser Gly Pro Ala Arg Asp Phe Ala Leu 
    50                  55                  60                  


Arg Leu Trp Asn Lys Val Pro Arg Lys Ala Val Val Glu Lys Pro Ala 
65                  70                  75                  80  


Arg Ala Ala Glu Arg Glu Ala Arg Ala Leu Leu Glu Lys Asn Arg Ser 
                85                  90                  95      


Tyr Arg Leu Leu Glu Asp Ser Glu Glu Ser Ser Glu Glu Thr Val Ser 
            100                 105                 110         


Arg Ala Gly Ser Ser Leu Gln Lys Lys Arg Lys Lys Arg Lys His Leu 
        115                 120                 125             


Arg Lys Lys Arg Glu Glu Glu Glu Glu Glu Glu Ala Ser Glu Lys Gly 
    130                 135                 140                 


Lys Lys Lys Thr Gly Gly Ser Lys Gln Gln Thr Glu Lys Pro Glu Ser 
145                 150                 155                 160 


Glu Asp Glu Trp Glu Arg Thr Glu Arg Glu Arg Leu Gln Asp Leu Glu 
                165                 170                 175     


Glu Arg Asp Ala Phe Ala Glu Arg Val Arg Gln Arg Asp Lys Asp Arg 
            180                 185                 190         


Thr Arg Asn Val Leu Glu Arg Ser Asp Lys Lys Ala Tyr Glu Glu Ala 
        195                 200                 205             


Gln Lys Arg Leu Lys Met Ala Glu Glu Asp Arg Lys Ala Met Ile Pro 
    210                 215                 220                 


Glu Leu Arg Lys Lys Ser Arg Arg Glu Tyr Leu Ala Lys Arg Glu Arg 
225                 230                 235                 240 


Glu Lys Leu Glu Asp Leu Glu Ala Glu Leu Ala Asp Glu Glu Phe Leu 
                245                 250                 255     


Phe Gly Asp Val Glu Leu Ser Arg His Glu Arg Gln Glu Leu Lys Tyr 
            260                 265                 270         


Lys Arg Arg Val Arg Asp Leu Ala Arg Glu Tyr Arg Ala Ala Gly Glu 
        275                 280                 285             


Gln Glu Lys Leu Glu Ala Thr Asn Arg Tyr His Met Pro Lys Glu Thr 
    290                 295                 300                 


Arg Gly Gln Pro Ala Arg Ala Val Asp Leu Val Glu Glu Glu Ser Gly 
305                 310                 315                 320 


Ala Pro Gly Glu Glu Gln Arg Arg Trp Glu Glu Ala Arg Leu Gly Ala 
                325                 330                 335     


Ala Ser Leu Lys Phe Gly Ala Arg Asp Ala Ala Ser Gln Glu Pro Lys 
            340                 345                 350         


Tyr Gln Leu Val Leu Glu Glu Glu Glu Thr Ile Glu Phe Val Arg Ala 
        355                 360                 365             


Thr Gln Leu Gln Gly Asp Glu Glu Pro Ser Ala Pro Pro Thr Ser Thr 
    370                 375                 380                 


Gln Ala Gln Gln Lys Glu Ser Ile Gln Ala Val Arg Arg Ser Leu Pro 
385                 390                 395                 400 


Val Phe Pro Phe Arg Glu Glu Leu Leu Ala Ala Ile Ala Asn His Gln 
                405                 410                 415     


Val Leu Ile Ile Glu Gly Glu Thr Gly Ser Gly Lys Thr Thr Gln Ile 
            420                 425                 430         


Pro Gln Tyr Leu Phe Glu Glu Gly Tyr Thr Asn Lys Gly Met Lys Ile 
        435                 440                 445             


Ala Cys Thr Gln Pro Arg Arg Val Ala Ala Met Ser Val Ala Ala Arg 
    450                 455                 460                 


Val Ala Arg Glu Met Gly Val Lys Leu Gly Asn Glu Val Gly Tyr Ser 
465                 470                 475                 480 


Ile Arg Phe Glu Asp Cys Thr Ser Glu Arg Thr Val Leu Arg Tyr Met 
                485                 490                 495     


Thr Asp Gly Met Leu Leu Arg Glu Phe Leu Ser Glu Pro Asp Leu Ala 
            500                 505                 510         


Ser Tyr Ser Val Val Met Val Asp Glu Ala His Glu Arg Thr Leu His 
        515                 520                 525             


Thr Asp Ile Leu Phe Gly Leu Ile Lys Asp Val Ala Arg Phe Arg Pro 
    530                 535                 540                 


Glu Leu Lys Val Leu Val Ala Ser Ala Thr Met Asp Thr Ala Arg Phe 
545                 550                 555                 560 


Ser Thr Phe Phe Asp Asp Ala Pro Val Phe Arg Ile Pro Gly Arg Arg 
                565                 570                 575     


Phe Pro Val Asp Ile Phe Tyr Thr Lys Ala Pro Glu Ala Asp Tyr Leu 
            580                 585                 590         


Glu Ala Cys Val Val Ser Val Leu Gln Ile His Val Thr Gln Pro Pro 
        595                 600                 605             


Gly Asp Ile Leu Val Phe Leu Thr Gly Gln Glu Glu Ile Glu Ala Ala 
    610                 615                 620                 


Cys Glu Met Leu Gln Asp Pro Cys Arg Arg Leu Gly Ser Lys Ile Arg 
625                 630                 635                 640 


Glu Leu Leu Val Leu Pro Ile Tyr Ala Asn Leu Pro Ser Asp Met Gln 
                645                 650                 655     


Ala Arg Ile Phe Gln Pro Thr Pro Pro Gly Ala Arg Lys Val Val Val 
            660                 665                 670         


Ala Thr Asn Ile Ala Glu Thr Ser Pro Thr Ile Glu Gly Ile Ile Tyr 
        675                 680                 685             


Val Leu Asp Pro Gly Phe Cys Lys Gln Lys Ser Tyr Asn Pro Arg Thr 
    690                 695                 700                 


Gly Met Glu Ser Leu Thr Val Thr Pro Cys Ser Lys Ala Ser Ala Asn 
705                 710                 715                 720 


Gln Arg Ala Gly Arg Ala Gly Arg Val Ala Ala Gly Lys Cys Phe Arg 
                725                 730                 735     


Leu Tyr Thr Ala Trp Ala Tyr Gln His Glu Leu Glu Glu Thr Thr Val 
            740                 745                 750         


Pro Glu Ile Gln Arg Thr Ser Leu Gly Asn Val Val Leu Leu Leu Lys 
        755                 760                 765             


Ser Leu Gly Ile His Asp Leu Met His Phe Asp Phe Leu Asp Pro Pro 
    770                 775                 780                 


Pro Tyr Glu Thr Leu Leu Leu Thr Leu Glu Gln Leu Tyr Ala Leu Gly 
785                 790                 795                 800 


Ala Leu Asn His Leu Gly Glu Leu Thr Thr Ser Gly Arg Lys Met Ala 
                805                 810                 815     


Glu Leu Pro Val Asp Pro Met Leu Ser Lys Met Ile Leu Ala Ser Glu 
            820                 825                 830         


Lys Tyr Ser Cys Ser Glu Glu Ile Leu Thr Val Ala Ala Met Leu Ser 
        835                 840                 845             


Val Asn Asn Ser Ile Phe Tyr Arg Pro Lys Asp Lys Val Val His Ala 
    850                 855                 860                 


Asp Asn Ala Arg Val Asn Phe Phe Leu Pro Gly Gly Asp His Leu Val 
865                 870                 875                 880 


Leu Leu Asn Val Tyr Thr Gln Trp Ala Glu Ser Gly Tyr Ser Ser Gln 
                885                 890                 895     


Trp Cys Cys Glu Asn Phe Val Gln Phe Arg Ser Met Arg Arg Ala Arg 
            900                 905                 910         


Asp Val Arg Glu Gln Leu Glu Gly Leu Leu Glu Arg Val Glu Val Gly 
        915                 920                 925             


Leu Ser Ser Cys Gln Gly Asp Tyr Ile Arg Val Arg Lys Ala Ile Thr 
    930                 935                 940                 


Ala Gly Tyr Phe Tyr His Thr Ala Arg Leu Thr Arg Ser Gly Tyr Arg 
945                 950                 955                 960 


Thr Val Lys Gln Gln Gln Thr Val Phe Ile His Pro Asn Ser Ser Leu 
                965                 970                 975     


Phe Glu Gln Gln Pro Arg Trp Leu Leu Tyr His Glu Leu Val Leu Thr 
            980                 985                 990         


Thr Lys Glu Phe Met Arg Gln Val  Leu Glu Ile Glu Ser  Ser Trp Leu 
        995                 1000                 1005             


Leu Glu  Val Ala Pro His Tyr  Tyr Lys Ala Lys Glu  Leu Glu Asp 
    1010                 1015                 1020             


Pro His  Ala Lys Lys Met Pro  Lys Lys Ile Gly Lys  Thr Arg Glu 
    1025                 1030                 1035             


Glu Leu  Gly 
    1040     


<210>  1442
<211>  1433
<212>  DNA
<213>  Homosapiens

<400>  1442
acccctccat ttctcgccat ggcccctgca ctgctcctga tccctgctgc cctcgcctct     60

ttcatcctgg cctttggcac cggagtggag ttcgtgcgct ttacctccct tcggccactt    120

cttggaggga tcccggagtc tggtggtccg gatgcccgcc agggatggct ggctgccctg    180

caggaccgca gcatccttgc ccccctggca tgggatctgg ggctcctgct tctatttgtt    240

gggcagcaca gcctcatggc agctgaaaga gtgaaggcat ggacatcccg gtactttggg    300

gtccttcaga ggtcactgta tgtggcctgc actgccctgg ccttgcagct ggtgatgcgg    360

tactgggagc ccatacccaa aggccctgtg ttgtgggagg ctcgggctga gccatgggcc    420

acctgggtgc cgctcctctg ctttgtgctc catgtcatct cctggctcct catctttagc    480

atccttctcg tctttgacta tgctgagctc atgggcctca aacaggtata ctaccatgtg    540

ctggggctgg gcgagcctct ggccctgaag tctccccggg ctctcagact cttctcccac    600

ctgcgccacc cagtgtgtgt ggagctgctg acagtgctgt gggtggtgcc taccctgggc    660

acggaccgtc tcctccttgc tttcctcctt accctctacc tgggcctggc tcacgggctt    720

gatcagcaag acctccgcta cctccgggcc cagctacaaa gaaaactcca cctgctctct    780

cggccccagg atggggaggc agagtgagga gctcactctg gttacaagcc ctgttcttcc    840

tctcccactg aattctaaat ccttaacatc caggccctgg ctgcttcatg ccagaggccc    900

aaatccatgg actgaaggag atgccccttc tactacttga gactttattc tctgggtcca    960

gctccatacc ctaaattctg agtttcagcc actgaactcc aaggtccact tctcaccagc   1020

aaggaagagt ggggtatgga agtcatctgt cccttcactg tttagagcat gacactctcc   1080

ccctcaacag cctcctgaga aggaaaggat ctgccctgac cactcccctg gcactgttac   1140

ttgcctctgc gcctcagggg tccccttctg caccgctggc ttccactcca agaaggtgga   1200

ccagggtctg caagttcaac ggtcatagct gtccctccag gccccaacct tgcctcacca   1260

ctcccggccc tagtctctgc acctccttag gccctgcctc tgggctcaga ccccaaccta   1320

gtcaagggga ttctcctgct cttaactcga tgacttgggg ctccctgctc tcccgaggaa   1380

gatgctctgc aggaaaataa aagtcagcct ttttctacaa aaaaaaaaaa aaa          1433


<210>  1443
<211>  262
<212>  PRT
<213>  Homosapiens

<400>  1443

Met Ala Pro Ala Leu Leu Leu Ile Pro Ala Ala Leu Ala Ser Phe Ile 
1               5                   10                  15      


Leu Ala Phe Gly Thr Gly Val Glu Phe Val Arg Phe Thr Ser Leu Arg 
            20                  25                  30          


Pro Leu Leu Gly Gly Ile Pro Glu Ser Gly Gly Pro Asp Ala Arg Gln 
        35                  40                  45              


Gly Trp Leu Ala Ala Leu Gln Asp Arg Ser Ile Leu Ala Pro Leu Ala 
    50                  55                  60                  


Trp Asp Leu Gly Leu Leu Leu Leu Phe Val Gly Gln His Ser Leu Met 
65                  70                  75                  80  


Ala Ala Glu Arg Val Lys Ala Trp Thr Ser Arg Tyr Phe Gly Val Leu 
                85                  90                  95      


Gln Arg Ser Leu Tyr Val Ala Cys Thr Ala Leu Ala Leu Gln Leu Val 
            100                 105                 110         


Met Arg Tyr Trp Glu Pro Ile Pro Lys Gly Pro Val Leu Trp Glu Ala 
        115                 120                 125             


Arg Ala Glu Pro Trp Ala Thr Trp Val Pro Leu Leu Cys Phe Val Leu 
    130                 135                 140                 


His Val Ile Ser Trp Leu Leu Ile Phe Ser Ile Leu Leu Val Phe Asp 
145                 150                 155                 160 


Tyr Ala Glu Leu Met Gly Leu Lys Gln Val Tyr Tyr His Val Leu Gly 
                165                 170                 175     


Leu Gly Glu Pro Leu Ala Leu Lys Ser Pro Arg Ala Leu Arg Leu Phe 
            180                 185                 190         


Ser His Leu Arg His Pro Val Cys Val Glu Leu Leu Thr Val Leu Trp 
        195                 200                 205             


Val Val Pro Thr Leu Gly Thr Asp Arg Leu Leu Leu Ala Phe Leu Leu 
    210                 215                 220                 


Thr Leu Tyr Leu Gly Leu Ala His Gly Leu Asp Gln Gln Asp Leu Arg 
225                 230                 235                 240 


Tyr Leu Arg Ala Gln Leu Gln Arg Lys Leu His Leu Leu Ser Arg Pro 
                245                 250                 255     


Gln Asp Gly Glu Ala Glu 
            260         


<210>  1444
<211>  6940
<212>  DNA
<213>  Homosapiens

<400>  1444
cttaaagtag atcatggagg acacccaggc tattgactgg gatgttgaag aagaggagga     60

gacagagcaa tccagtgaat ccttgaggtg taacgtggag ccagtagggc ggctacatat    120

ctttagtggt gcccatggac cagaaaaaga tttcccacta cacctcggga agaatgtggt    180

aggccgaatg cctgactgct ctgtggccct gccctttcca tctatctcca aacaacatgc    240

agagattgaa atcttagcct gggacaaggc acctatcctc cgagactgtg ggagccttaa    300

tggtactcaa atcctgagac ctcctaaggt tttgagccct ggggtgagtc accgtctgag    360

ggaccaggaa ttgattctct ttgctgactt gctctgccag taccatcgcc tggatgtctc    420

tctgcccttt gtctcccggg gccctctgac agtagaagag acacccagag tacagggaga    480

aactcaaccc cagaggcttc tgttggctga ggactcggag gaggaagtag attttctttc    540

tgaaaggcgt atggtaaaaa aatcaaggac cacatcttcc tctgtgatag ttccagagag    600

tgatgaagag gggcattccc cggtcctggg cggccttggg ccgccttttg ccttcaattt    660

gaacagtgac acagatgtgg aagaaggtca gcaaccagcc acagaggagg cctcctcagc    720

tgccagaaga ggtgccactg tagaggcaaa gcagtctgaa gctgaagttg taactgaaat    780

ccagcttgaa aaggatcagc ctttagtgaa ggagagggac aatgatacaa aagtcaagag    840

gggtgcaggg aatggggtgg ttccagctgg ggtgattctg gagaggagcc aacctcctgg    900

agaggacagt gacacagatg tggatgatga cagcaggcct cctggaaggc cagctgaggt    960

ccatttggaa agggctcagc cttttggctt catcgacagc gacactgatg cggaagaaga   1020

gaggatccca gcaaccccag ttgtcattcc tatgaagaag aggaagatct tccatggagt   1080

aggtacaagg ggtcctggag caccaggcct ggcccatctg caggagagcc aggctggtag   1140

tgatacagat gtggaagaag gcaaggcccc acaggctgtc cctctggaga aaagccaagc   1200

ttccatggtt atcaacagcg atacagatga cgaggaagaa gtctcagcag cgctgacttt   1260

ggcacatctg aaagagagcc agcctgctat atggaacaga gatgcagaag aggacatgcc   1320

ccaacgtgtg gtccttctgc agcgaagcca aaccaccact gagagagaca gtgacacaga   1380

cgtggaggag gaagagctcc cagtggaaaa tagagaagct gtcctcaagg atcacacaaa   1440

gattagagcc cttgttagag cacattcaga aaaggaccaa cctccttttg gggacagtga   1500

tgacagtgtg gaagcagata agagctcacc tgggatccac ctggagagaa gccaagcctc   1560

caccacagtg gacatcaaca cacaagtgga gaaggaagtc ccgccagggt cagccattat   1620

gcatataaag aagcatcagg tgtctgtgga ggggacaaat caaacagatg tgaaagcagt   1680

tgggggacca gcaaagctgc ttgtggtatc tctagaggaa gcctggcctc tgcatgggga   1740

ctgtgaaaca gatgcagagg agggcacctc cctaacagcc tcagtagttg cagatgtaag   1800

aaagagccag cttccagcag aaggggatgc tggggcagag tgggctgcag ctgttcttaa   1860

gcaggagaga gctcatgagg tgggggccca gggtgggcca cctgtggcac aagtggagca   1920

ggacctccct atctcaagag agaacctcac agatctggtg gtggacacag acactctagg   1980

ggaatccacc cagccacaga gagagggagc ccaggtcccc acaggaaggg agagagaaca   2040

acatgtgggt gggaccaagg actctgaaga caactatggt gattctgaag atctggacct   2100

acaagctacc cagtgctttc tggagaatca gggcctggaa gcagtccaga gcatggagga   2160

tgaacctacc caggccttca tgttgactcc accccaagag cttggccctt cccattgcag   2220

cttccagaca acaggtaccc tagatgaacc atgggaggtc ctggctacac agccattctg   2280

tctgagagag tctgaggact ctgagaccca gccttttgac acgcaccttg aggcctatgg   2340

accttgcctg tctccaccta gggcaatacc aggagaccaa catccagaga gcccagttca   2400

cacagagcca atggggattc aaggcagagg gaggcagact gtggataaag tcatgggtat   2460

accaaaagaa acagcagaga gggtgggccc tgagagaggg ccattggaga gagaaactga   2520

gaaactgcta ccagaaagac agacagatgt gacaggagag gaagaattaa ccaaggggaa   2580

acaggacaga gaacaaaaac agttgttagc tagagacacc cagagacaag aatctgacaa   2640

aaatggggaa agtgcaagtc ctgaaagaga tagggagagt ttgaaggtag aaattgagac   2700

atctgaggaa atacaagaga aacaagtaca gaagcagacc cttccaagca aagcatttga   2760

gagagaagta gagagaccag tagcaaacag agagtgcgat ccagccgagt tagaagagaa   2820

ggtgcccaaa gtgatcctgg agagagatac acagagaggg gagccagagg gagggagcca   2880

ggaccagaaa gggcaggcct ccagcccaac accagagcct ggggtggggg cgggggacct   2940

tccgggacct acctcagccc ccgtaccttc tgggagccag tcaggtggaa ggggatcccc   3000

agtgagcccc aggaggcatc agaaaggcct cctgaattgc aagatgccac ctgctgagaa   3060

ggcttccagg atcagagctg ctgagaaggt ttccaggggc gatcaggaat ctccagatgc   3120

ttgtctgcct cctgcagtac ctgaagcccc agccccaccc caaaagcccc ttaactctca   3180

gagccagaaa catcttgcac ctccgcccct tctttctccc cttttacctt ctatcaagcc   3240

aaccgttcgt aagaccaggc aagatgggag tcaggaagct ccagaggctc ccttgtcctc   3300

agagctggag cctttccacc caaagcctaa aattagaact cggaagtcct ccagaatgac   3360

accctttcca gctacctctg ctgcccctga gccccaccct tccacctcca cagcccagcc   3420

agtcactccc aagcccacat ctcaggccac taggagcagg acaaataggt cctctgtcaa   3480

gacccctgaa ccagttgtcc ccacagcccc tgagctccag ccttccacct ccacagacca   3540

gcctgtcacc tctgagccca catctcaggt tactagggga agaaaaagta gatcctctgt   3600

caagacccct gaaacagttg tgcccacagc ccttgagctc cagccttcca cctccaccga   3660

ccgacctgtc acctctgaac ccacctctca ggctactagg ggaagaaaaa atagatcctc   3720

tgtcaagacc cctgaaccag ttgtccccac agcccctgag ctccagcctt ccacctccac   3780

agaccagcct gtcacttctg agcccacata tcaggctact aggggaagaa aaaatagatc   3840

ctctgtcaag acccctgaac cagttgtgcc cacagcccct gagctccggc cttccacctc   3900

cacagaccga cctgtcaccc ccaagcccac atctcggacc actaggagca ggacaaatat   3960

gtcctctgtc aagacccctg aaacagttgt ccccacagcc cctgagctcc agatttccac   4020

ctccacagac caacctgtca cccctaagcc cacatctcgg accactagga gcaggacaaa   4080

tatgtcctct gtgaagaacc ctgaatcaac tgtccctata gcccctgagc tcccaccttc   4140

cacctccaca gagcagcctg tcacccctga gcccacatct cgggctacta ggggaagaaa   4200

aaatagatcc tctggcaaga cccctgaaac acttgtcccc acagccccta agctcgagcc   4260

ttccacttcc acagaccaac ctgtcactcc tgagcccaca tctcaggcca ccaggggcag   4320

gacaaatagg tcctctgtga agacccctga aacagttgtc cccacagccc ctgagctcca   4380

gccttccacc tccacagacc agcctgttac ccctgagcct acgtctcagg ctactagggg   4440

aagaacagat agatcctctg tcaagactcc tgaaacagtt gtccccacag cccctgagct   4500

acaggcttcc gcctccacag accagcctgt cacctctgag cccacatctc ggaccactag   4560

gggaagaaaa aatcggtcct ctgtcaagac ccctgaaaca gttgtgcccg cagcccctga   4620

gctccagcct cccacctcca cagaccgacc tgtcacccct gagcccacat ctcgggccac   4680

taggggcagg acaaataggt cctctgtcaa gacccctgaa tcaattgtcc ctatagcccc   4740

tgagcttcag ccttccacct ccagaaacca gcttgtcacc cctgagccca catctcgggc   4800

cactaggtgc aggacaaata ggtcctctgt caagacccct gagccagttg tccccacagc   4860

ccctgagccc catcctacca cctccacaga ccagcctgtc acccccaagc tcacatctag   4920

ggccactagg agaaagacaa ataggtcctc tgtcaagact cccaaaccag ttgaaccagc   4980

agcctctgat cttgagcctt ttacccccac agaccagtcc gtcacccctg aggccatagc   5040

tcagggtggt cagagcaaaa cactgaggtc ttccacagta agagctatgc cggttcctac   5100

cacccctgaa ttccaatctc ctgtcaccac agaccagcct atttcccctg agcctattac   5160

tcaacccagt tgcatcaaga ggcagagagc cgctgggaac cctggctccc tcgcagctcc   5220

cattgaccat aagccttgct ctgcaccctt ggaacctaaa tcccaggcct caaggaacca   5280

aagatgggga gcagtgagag cagctgaatc ccttacagcc attcctgagc ctgcctctcc   5340

ccagcttctt gagacaccaa ttcatgcctc ccagatccaa aaggtggaac cagcaggtag   5400

atctaggttc accccggagc tccagcctaa ggcctctcaa agccgcaaga ggtctttagc   5460

taccatggat tcaccaccac atcaaaaaca gccccaaaga ggggaagtct cccagaagac   5520

agtgattatc aaggaagagg aagaagatac tgcagagaag ccagggaagg aagaggatgt   5580

cgtgactcca aaaccaggca agagaaagag agaccaggca gaggaggagc ccaacagaat   5640

accaagccgc agcctccgac ggaccaaact taaccaagaa tcaacagccc ccaaagtgct   5700

cttcacagga gtggtggatg ctcggggaga gcgggctgtg ctggcactgg ggggaagtct   5760

ggctggttca gcggcagagg cttcccacct ggtcactgat cgcatccgcc ggacagtcaa   5820

gttcctgtgt gccctggggc ggggaatccc cattctgtcc ctggactggc tgcatcagtc   5880

ccgcaaggct ggtttcttct tacccccgga tgaatatgtg gtgaccgacc ctgagcaaga   5940

gaagaacttt ggctttagcc ttcaagacgc actgagcagg gctcgggagc gaaggctgct   6000

agagggctat gagatctatg tgacccctgg agtccagcca ccaccacctc agatgggaga   6060

gattattagc tgctgtggag gcacatacct acccagcatg cctcggtcct ataagcctca   6120

gagagttgtg atcacatgcc ctcaggactt ccctcattgc tccattccac tacgggttgg   6180

gctgcccctc ctctcgcctg agttcctgct gactggagtg ctgaagcagg aagccaagcc   6240

agaggccttt gtcctctccc ctttggagat gtcatccacc tgagaactcc actacccttt   6300

tccctcccag accacgaatt agaagatatg tggaagaaag aactcagggc gttagaaagg   6360

attggggtat attgatacaa cttgtcctgg aacatgggtg ggaccagaaa tctttatgaa   6420

taaatgaaaa gataagggat ttggaagcca caggttgttt tttgtttgtt tgtttgtttt   6480

tttaatggcc attttatttt atttgtattt atagtttttt atttgtatag atttagggga   6540

tacaagattt cttacatgca tgtattaaat ggccatttta aaattagcta gtttcatgct   6600

cagatgtcat aagtggcagc tatctttagc cagactgttg cagttattgc tcgatgccac   6660

tcatggtgtc ctacctccta tttggaaacc atctctattt ttttcttact gagattctta   6720

ctttggggtc aggaacttga agggatgctt ggagtgagta gatttgaggg tccagttatg   6780

gagtgctact aaaacatttt cttctctcct ggcctctgga agcatcttta gctttgactt   6840

tgggcaagtc tctgtacttt tctggccagc ttttccagga tttataaaat tagagcttcg   6900

gcttgacctc tgtgataaat aaatattcac tctgtgcctt                         6940


<210>  1445
<211>  2089
<212>  PRT
<213>  Homosapiens

<400>  1445

Met Glu Asp Thr Gln Ala Ile Asp Trp Asp Val Glu Glu Glu Glu Glu 
1               5                   10                  15      


Thr Glu Gln Ser Ser Glu Ser Leu Arg Cys Asn Val Glu Pro Val Gly 
            20                  25                  30          


Arg Leu His Ile Phe Ser Gly Ala His Gly Pro Glu Lys Asp Phe Pro 
        35                  40                  45              


Leu His Leu Gly Lys Asn Val Val Gly Arg Met Pro Asp Cys Ser Val 
    50                  55                  60                  


Ala Leu Pro Phe Pro Ser Ile Ser Lys Gln His Ala Glu Ile Glu Ile 
65                  70                  75                  80  


Leu Ala Trp Asp Lys Ala Pro Ile Leu Arg Asp Cys Gly Ser Leu Asn 
                85                  90                  95      


Gly Thr Gln Ile Leu Arg Pro Pro Lys Val Leu Ser Pro Gly Val Ser 
            100                 105                 110         


His Arg Leu Arg Asp Gln Glu Leu Ile Leu Phe Ala Asp Leu Leu Cys 
        115                 120                 125             


Gln Tyr His Arg Leu Asp Val Ser Leu Pro Phe Val Ser Arg Gly Pro 
    130                 135                 140                 


Leu Thr Val Glu Glu Thr Pro Arg Val Gln Gly Glu Thr Gln Pro Gln 
145                 150                 155                 160 


Arg Leu Leu Leu Ala Glu Asp Ser Glu Glu Glu Val Asp Phe Leu Ser 
                165                 170                 175     


Glu Arg Arg Met Val Lys Lys Ser Arg Thr Thr Ser Ser Ser Val Ile 
            180                 185                 190         


Val Pro Glu Ser Asp Glu Glu Gly His Ser Pro Val Leu Gly Gly Leu 
        195                 200                 205             


Gly Pro Pro Phe Ala Phe Asn Leu Asn Ser Asp Thr Asp Val Glu Glu 
    210                 215                 220                 


Gly Gln Gln Pro Ala Thr Glu Glu Ala Ser Ser Ala Ala Arg Arg Gly 
225                 230                 235                 240 


Ala Thr Val Glu Ala Lys Gln Ser Glu Ala Glu Val Val Thr Glu Ile 
                245                 250                 255     


Gln Leu Glu Lys Asp Gln Pro Leu Val Lys Glu Arg Asp Asn Asp Thr 
            260                 265                 270         


Lys Val Lys Arg Gly Ala Gly Asn Gly Val Val Pro Ala Gly Val Ile 
        275                 280                 285             


Leu Glu Arg Ser Gln Pro Pro Gly Glu Asp Ser Asp Thr Asp Val Asp 
    290                 295                 300                 


Asp Asp Ser Arg Pro Pro Gly Arg Pro Ala Glu Val His Leu Glu Arg 
305                 310                 315                 320 


Ala Gln Pro Phe Gly Phe Ile Asp Ser Asp Thr Asp Ala Glu Glu Glu 
                325                 330                 335     


Arg Ile Pro Ala Thr Pro Val Val Ile Pro Met Lys Lys Arg Lys Ile 
            340                 345                 350         


Phe His Gly Val Gly Thr Arg Gly Pro Gly Ala Pro Gly Leu Ala His 
        355                 360                 365             


Leu Gln Glu Ser Gln Ala Gly Ser Asp Thr Asp Val Glu Glu Gly Lys 
    370                 375                 380                 


Ala Pro Gln Ala Val Pro Leu Glu Lys Ser Gln Ala Ser Met Val Ile 
385                 390                 395                 400 


Asn Ser Asp Thr Asp Asp Glu Glu Glu Val Ser Ala Ala Leu Thr Leu 
                405                 410                 415     


Ala His Leu Lys Glu Ser Gln Pro Ala Ile Trp Asn Arg Asp Ala Glu 
            420                 425                 430         


Glu Asp Met Pro Gln Arg Val Val Leu Leu Gln Arg Ser Gln Thr Thr 
        435                 440                 445             


Thr Glu Arg Asp Ser Asp Thr Asp Val Glu Glu Glu Glu Leu Pro Val 
    450                 455                 460                 


Glu Asn Arg Glu Ala Val Leu Lys Asp His Thr Lys Ile Arg Ala Leu 
465                 470                 475                 480 


Val Arg Ala His Ser Glu Lys Asp Gln Pro Pro Phe Gly Asp Ser Asp 
                485                 490                 495     


Asp Ser Val Glu Ala Asp Lys Ser Ser Pro Gly Ile His Leu Glu Arg 
            500                 505                 510         


Ser Gln Ala Ser Thr Thr Val Asp Ile Asn Thr Gln Val Glu Lys Glu 
        515                 520                 525             


Val Pro Pro Gly Ser Ala Ile Met His Ile Lys Lys His Gln Val Ser 
    530                 535                 540                 


Val Glu Gly Thr Asn Gln Thr Asp Val Lys Ala Val Gly Gly Pro Ala 
545                 550                 555                 560 


Lys Leu Leu Val Val Ser Leu Glu Glu Ala Trp Pro Leu His Gly Asp 
                565                 570                 575     


Cys Glu Thr Asp Ala Glu Glu Gly Thr Ser Leu Thr Ala Ser Val Val 
            580                 585                 590         


Ala Asp Val Arg Lys Ser Gln Leu Pro Ala Glu Gly Asp Ala Gly Ala 
        595                 600                 605             


Glu Trp Ala Ala Ala Val Leu Lys Gln Glu Arg Ala His Glu Val Gly 
    610                 615                 620                 


Ala Gln Gly Gly Pro Pro Val Ala Gln Val Glu Gln Asp Leu Pro Ile 
625                 630                 635                 640 


Ser Arg Glu Asn Leu Thr Asp Leu Val Val Asp Thr Asp Thr Leu Gly 
                645                 650                 655     


Glu Ser Thr Gln Pro Gln Arg Glu Gly Ala Gln Val Pro Thr Gly Arg 
            660                 665                 670         


Glu Arg Glu Gln His Val Gly Gly Thr Lys Asp Ser Glu Asp Asn Tyr 
        675                 680                 685             


Gly Asp Ser Glu Asp Leu Asp Leu Gln Ala Thr Gln Cys Phe Leu Glu 
    690                 695                 700                 


Asn Gln Gly Leu Glu Ala Val Gln Ser Met Glu Asp Glu Pro Thr Gln 
705                 710                 715                 720 


Ala Phe Met Leu Thr Pro Pro Gln Glu Leu Gly Pro Ser His Cys Ser 
                725                 730                 735     


Phe Gln Thr Thr Gly Thr Leu Asp Glu Pro Trp Glu Val Leu Ala Thr 
            740                 745                 750         


Gln Pro Phe Cys Leu Arg Glu Ser Glu Asp Ser Glu Thr Gln Pro Phe 
        755                 760                 765             


Asp Thr His Leu Glu Ala Tyr Gly Pro Cys Leu Ser Pro Pro Arg Ala 
    770                 775                 780                 


Ile Pro Gly Asp Gln His Pro Glu Ser Pro Val His Thr Glu Pro Met 
785                 790                 795                 800 


Gly Ile Gln Gly Arg Gly Arg Gln Thr Val Asp Lys Val Met Gly Ile 
                805                 810                 815     


Pro Lys Glu Thr Ala Glu Arg Val Gly Pro Glu Arg Gly Pro Leu Glu 
            820                 825                 830         


Arg Glu Thr Glu Lys Leu Leu Pro Glu Arg Gln Thr Asp Val Thr Gly 
        835                 840                 845             


Glu Glu Glu Leu Thr Lys Gly Lys Gln Asp Arg Glu Gln Lys Gln Leu 
    850                 855                 860                 


Leu Ala Arg Asp Thr Gln Arg Gln Glu Ser Asp Lys Asn Gly Glu Ser 
865                 870                 875                 880 


Ala Ser Pro Glu Arg Asp Arg Glu Ser Leu Lys Val Glu Ile Glu Thr 
                885                 890                 895     


Ser Glu Glu Ile Gln Glu Lys Gln Val Gln Lys Gln Thr Leu Pro Ser 
            900                 905                 910         


Lys Ala Phe Glu Arg Glu Val Glu Arg Pro Val Ala Asn Arg Glu Cys 
        915                 920                 925             


Asp Pro Ala Glu Leu Glu Glu Lys Val Pro Lys Val Ile Leu Glu Arg 
    930                 935                 940                 


Asp Thr Gln Arg Gly Glu Pro Glu Gly Gly Ser Gln Asp Gln Lys Gly 
945                 950                 955                 960 


Gln Ala Ser Ser Pro Thr Pro Glu Pro Gly Val Gly Ala Gly Asp Leu 
                965                 970                 975     


Pro Gly Pro Thr Ser Ala Pro Val Pro Ser Gly Ser Gln Ser Gly Gly 
            980                 985                 990         


Arg Gly Ser Pro Val Ser Pro Arg  Arg His Gln Lys Gly  Leu Leu Asn 
        995                 1000                 1005             


Cys Lys  Met Pro Pro Ala Glu  Lys Ala Ser Arg Ile  Arg Ala Ala 
    1010                 1015                 1020             


Glu Lys  Val Ser Arg Gly Asp  Gln Glu Ser Pro Asp  Ala Cys Leu 
    1025                 1030                 1035             


Pro Pro  Ala Val Pro Glu Ala  Pro Ala Pro Pro Gln  Lys Pro Leu 
    1040                 1045                 1050             


Asn Ser  Gln Ser Gln Lys His  Leu Ala Pro Pro Pro  Leu Leu Ser 
    1055                 1060                 1065             


Pro Leu  Leu Pro Ser Ile Lys  Pro Thr Val Arg Lys  Thr Arg Gln 
    1070                 1075                 1080             


Asp Gly  Ser Gln Glu Ala Pro  Glu Ala Pro Leu Ser  Ser Glu Leu 
    1085                 1090                 1095             


Glu Pro  Phe His Pro Lys Pro  Lys Ile Arg Thr Arg  Lys Ser Ser 
    1100                 1105                 1110             


Arg Met  Thr Pro Phe Pro Ala  Thr Ser Ala Ala Pro  Glu Pro His 
    1115                 1120                 1125             


Pro Ser  Thr Ser Thr Ala Gln  Pro Val Thr Pro Lys  Pro Thr Ser 
    1130                 1135                 1140             


Gln Ala  Thr Arg Ser Arg Thr  Asn Arg Ser Ser Val  Lys Thr Pro 
    1145                 1150                 1155             


Glu Pro  Val Val Pro Thr Ala  Pro Glu Leu Gln Pro  Ser Thr Ser 
    1160                 1165                 1170             


Thr Asp  Gln Pro Val Thr Ser  Glu Pro Thr Ser Gln  Val Thr Arg 
    1175                 1180                 1185             


Gly Arg  Lys Ser Arg Ser Ser  Val Lys Thr Pro Glu  Thr Val Val 
    1190                 1195                 1200             


Pro Thr  Ala Leu Glu Leu Gln  Pro Ser Thr Ser Thr  Asp Arg Pro 
    1205                 1210                 1215             


Val Thr  Ser Glu Pro Thr Ser  Gln Ala Thr Arg Gly  Arg Lys Asn 
    1220                 1225                 1230             


Arg Ser  Ser Val Lys Thr Pro  Glu Pro Val Val Pro  Thr Ala Pro 
    1235                 1240                 1245             


Glu Leu  Gln Pro Ser Thr Ser  Thr Asp Gln Pro Val  Thr Ser Glu 
    1250                 1255                 1260             


Pro Thr  Tyr Gln Ala Thr Arg  Gly Arg Lys Asn Arg  Ser Ser Val 
    1265                 1270                 1275             


Lys Thr  Pro Glu Pro Val Val  Pro Thr Ala Pro Glu  Leu Arg Pro 
    1280                 1285                 1290             


Ser Thr  Ser Thr Asp Arg Pro  Val Thr Pro Lys Pro  Thr Ser Arg 
    1295                 1300                 1305             


Thr Thr  Arg Ser Arg Thr Asn  Met Ser Ser Val Lys  Thr Pro Glu 
    1310                 1315                 1320             


Thr Val  Val Pro Thr Ala Pro  Glu Leu Gln Ile Ser  Thr Ser Thr 
    1325                 1330                 1335             


Asp Gln  Pro Val Thr Pro Lys  Pro Thr Ser Arg Thr  Thr Arg Ser 
    1340                 1345                 1350             


Arg Thr  Asn Met Ser Ser Val  Lys Asn Pro Glu Ser  Thr Val Pro 
    1355                 1360                 1365             


Ile Ala  Pro Glu Leu Pro Pro  Ser Thr Ser Thr Glu  Gln Pro Val 
    1370                 1375                 1380             


Thr Pro  Glu Pro Thr Ser Arg  Ala Thr Arg Gly Arg  Lys Asn Arg 
    1385                 1390                 1395             


Ser Ser  Gly Lys Thr Pro Glu  Thr Leu Val Pro Thr  Ala Pro Lys 
    1400                 1405                 1410             


Leu Glu  Pro Ser Thr Ser Thr  Asp Gln Pro Val Thr  Pro Glu Pro 
    1415                 1420                 1425             


Thr Ser  Gln Ala Thr Arg Gly  Arg Thr Asn Arg Ser  Ser Val Lys 
    1430                 1435                 1440             


Thr Pro  Glu Thr Val Val Pro  Thr Ala Pro Glu Leu  Gln Pro Ser 
    1445                 1450                 1455             


Thr Ser  Thr Asp Gln Pro Val  Thr Pro Glu Pro Thr  Ser Gln Ala 
    1460                 1465                 1470             


Thr Arg  Gly Arg Thr Asp Arg  Ser Ser Val Lys Thr  Pro Glu Thr 
    1475                 1480                 1485             


Val Val  Pro Thr Ala Pro Glu  Leu Gln Ala Ser Ala  Ser Thr Asp 
    1490                 1495                 1500             


Gln Pro  Val Thr Ser Glu Pro  Thr Ser Arg Thr Thr  Arg Gly Arg 
    1505                 1510                 1515             


Lys Asn  Arg Ser Ser Val Lys  Thr Pro Glu Thr Val  Val Pro Ala 
    1520                 1525                 1530             


Ala Pro  Glu Leu Gln Pro Pro  Thr Ser Thr Asp Arg  Pro Val Thr 
    1535                 1540                 1545             


Pro Glu  Pro Thr Ser Arg Ala  Thr Arg Gly Arg Thr  Asn Arg Ser 
    1550                 1555                 1560             


Ser Val  Lys Thr Pro Glu Ser  Ile Val Pro Ile Ala  Pro Glu Leu 
    1565                 1570                 1575             


Gln Pro  Ser Thr Ser Arg Asn  Gln Leu Val Thr Pro  Glu Pro Thr 
    1580                 1585                 1590             


Ser Arg  Ala Thr Arg Cys Arg  Thr Asn Arg Ser Ser  Val Lys Thr 
    1595                 1600                 1605             


Pro Glu  Pro Val Val Pro Thr  Ala Pro Glu Pro His  Pro Thr Thr 
    1610                 1615                 1620             


Ser Thr  Asp Gln Pro Val Thr  Pro Lys Leu Thr Ser  Arg Ala Thr 
    1625                 1630                 1635             


Arg Arg  Lys Thr Asn Arg Ser  Ser Val Lys Thr Pro  Lys Pro Val 
    1640                 1645                 1650             


Glu Pro  Ala Ala Ser Asp Leu  Glu Pro Phe Thr Pro  Thr Asp Gln 
    1655                 1660                 1665             


Ser Val  Thr Pro Glu Ala Ile  Ala Gln Gly Gly Gln  Ser Lys Thr 
    1670                 1675                 1680             


Leu Arg  Ser Ser Thr Val Arg  Ala Met Pro Val Pro  Thr Thr Pro 
    1685                 1690                 1695             


Glu Phe  Gln Ser Pro Val Thr  Thr Asp Gln Pro Ile  Ser Pro Glu 
    1700                 1705                 1710             


Pro Ile  Thr Gln Pro Ser Cys  Ile Lys Arg Gln Arg  Ala Ala Gly 
    1715                 1720                 1725             


Asn Pro  Gly Ser Leu Ala Ala  Pro Ile Asp His Lys  Pro Cys Ser 
    1730                 1735                 1740             


Ala Pro  Leu Glu Pro Lys Ser  Gln Ala Ser Arg Asn  Gln Arg Trp 
    1745                 1750                 1755             


Gly Ala  Val Arg Ala Ala Glu  Ser Leu Thr Ala Ile  Pro Glu Pro 
    1760                 1765                 1770             


Ala Ser  Pro Gln Leu Leu Glu  Thr Pro Ile His Ala  Ser Gln Ile 
    1775                 1780                 1785             


Gln Lys  Val Glu Pro Ala Gly  Arg Ser Arg Phe Thr  Pro Glu Leu 
    1790                 1795                 1800             


Gln Pro  Lys Ala Ser Gln Ser  Arg Lys Arg Ser Leu  Ala Thr Met 
    1805                 1810                 1815             


Asp Ser  Pro Pro His Gln Lys  Gln Pro Gln Arg Gly  Glu Val Ser 
    1820                 1825                 1830             


Gln Lys  Thr Val Ile Ile Lys  Glu Glu Glu Glu Asp  Thr Ala Glu 
    1835                 1840                 1845             


Lys Pro  Gly Lys Glu Glu Asp  Val Val Thr Pro Lys  Pro Gly Lys 
    1850                 1855                 1860             


Arg Lys  Arg Asp Gln Ala Glu  Glu Glu Pro Asn Arg  Ile Pro Ser 
    1865                 1870                 1875             


Arg Ser  Leu Arg Arg Thr Lys  Leu Asn Gln Glu Ser  Thr Ala Pro 
    1880                 1885                 1890             


Lys Val  Leu Phe Thr Gly Val  Val Asp Ala Arg Gly  Glu Arg Ala 
    1895                 1900                 1905             


Val Leu  Ala Leu Gly Gly Ser  Leu Ala Gly Ser Ala  Ala Glu Ala 
    1910                 1915                 1920             


Ser His  Leu Val Thr Asp Arg  Ile Arg Arg Thr Val  Lys Phe Leu 
    1925                 1930                 1935             


Cys Ala  Leu Gly Arg Gly Ile  Pro Ile Leu Ser Leu  Asp Trp Leu 
    1940                 1945                 1950             


His Gln  Ser Arg Lys Ala Gly  Phe Phe Leu Pro Pro  Asp Glu Tyr 
    1955                 1960                 1965             


Val Val  Thr Asp Pro Glu Gln  Glu Lys Asn Phe Gly  Phe Ser Leu 
    1970                 1975                 1980             


Gln Asp  Ala Leu Ser Arg Ala  Arg Glu Arg Arg Leu  Leu Glu Gly 
    1985                 1990                 1995             


Tyr Glu  Ile Tyr Val Thr Pro  Gly Val Gln Pro Pro  Pro Pro Gln 
    2000                 2005                 2010             


Met Gly  Glu Ile Ile Ser Cys  Cys Gly Gly Thr Tyr  Leu Pro Ser 
    2015                 2020                 2025             


Met Pro  Arg Ser Tyr Lys Pro  Gln Arg Val Val Ile  Thr Cys Pro 
    2030                 2035                 2040             


Gln Asp  Phe Pro His Cys Ser  Ile Pro Leu Arg Val  Gly Leu Pro 
    2045                 2050                 2055             


Leu Leu  Ser Pro Glu Phe Leu  Leu Thr Gly Val Leu  Lys Gln Glu 
    2060                 2065                 2070             


Ala Lys  Pro Glu Ala Phe Val  Leu Ser Pro Leu Glu  Met Ser Ser 
    2075                 2080                 2085             


Thr 
    


<210>  1446
<211>  2510
<212>  DNA
<213>  Homosapiens

<400>  1446
gcacctcgct gctccagcct ctggggcgca ttccaacctt ccagcctgcg acctgcggag     60

aaaaaaaatt acttattttc ttgccccata cataccttga ggcgagcaaa aaaattaaat    120

tttaaccatg agggaaatcg tgcacatcca ggctggtcag tgtggcaacc agatcggtgc    180

caagttctgg gaggtgatca gtgatgaaca tggcatcgac cccaccggca cctaccacgg    240

ggacagcgac ctgcagctgg accgcatctc tgtgtactac aatgaagcca caggtggcaa    300

atatgttcct cgtgccatcc tggtggatct agaacctggg accatggact ctgttcgctc    360

aggtcctttt ggccagatct ttagaccaga caactttgta tttggtcagt ctggggcagg    420

taacaactgg gccaaaggcc actacacaga gggcgccgag ctggttgatt ctgtcctgga    480

tgtggtacgg aaggaggcag agagctgtga ctgcctgcag ggcttccagc tgacccactc    540

actgggcggg ggcacaggct ctggaatggg cactctcctt atcagcaaga tccgagaaga    600

ataccctgat cgcatcatga ataccttcag tgtggtgcct tcacccaaag tgtctgacac    660

cgtggtcgag ccctacaatg ccaccctctc cgtccatcag ttggtagaga atactgatga    720

gacctattgc attgacaacg aggccctcta tgatatctgc ttccgcactc tgaagctgac    780

cacaccaacc tacggggatc tgaaccacct tgtctcagcc accatgagtg gtgtcaccac    840

ctgcctccgt ttccctggcc agctcaatgc tgacctccgc aagttggcag tcaacatggt    900

ccccttccca cgtctccatt tctttatgcc tggctttgcc cctctcacca gccgtggaag    960

ccagcagtat cgagctctca cagtgccgga actcacccag caggtcttcg atgccaagaa   1020

catgatggct gcctgtgacc cccgccacgg ccgatacctc accgtggctg ctgtcttccg   1080

tggtcggatg tccatgaagg aggtcgatga gcagatgctt aacgtgcaga acaagaacag   1140

cagctacttt gtggaatgga tccccaacaa tgtcaagaca gccgtctgtg acatcccacc   1200

tcgtggcctc aagatggcag tcaccttcat tggcaatagc acagccatcc aggagctctt   1260

caagcgcatc tcggagcagt tcactgccat gttccgccgg aaggccttcc tccactggta   1320

cacaggcgag ggcatggacg agatggagtt caccgaggct gagagcaaca tgaacgacct   1380

cgtctctgag tatcagcagt accaggatgc caccgcagaa gaggaggagg atttcggtga   1440

ggaggccgaa gaggaggcct aaggcagagc ccccatcacc tcaggcttct cagttccctt   1500

agccgtctta ctcaactgcc cctttcctct ccctcagaat ttgtgtttgc tgcctctatc   1560

ttgttttttg ttttttcttc tggggggggt ctagaacagt gcctggcaca tagtaggcgc   1620

tcaataaata cttgtttgtt gaatgtctcc tctctctttc cactctggga aacctaggtt   1680

tctgccattc tgggtgaccc tgtatttctt tctggtgccc attccatttg tccagttaat   1740

acttcctctt aaaaatctcc aagaagctgg gtctccagat cccatttaga accaaccagg   1800

tgctgaaaac acatgtagat aatggccatc atcctaagcc caaagtagaa aatggtagaa   1860

ggtagtgggt agaagtcact atataaggaa ggggatggga ttttccattc taaaagtttt   1920

ggagagggaa atccaggcta ttaaagtcac taaatttcta agtatgtcca tttcccatct   1980

cagcttcaag ggaggtgtca gcagtattat ctccactttc aatctccctc caagctctac   2040

tctggaggag tctgtcccac tctgtcaagt ggaatccttc cctttccaac tctacctccc   2100

tcactcagct cctttcccct gatcagagaa agggatcaag ggggttggga ggggggaaag   2160

agaccagcct tggtccctaa gcctccagaa acgtcttctt aatccccacc ttttcttact   2220

cccaaaaaag aatgaacacc cctgactctg gagtggtgta tactgccaca tcagtgtttg   2280

agtcagtccc cagaggagag gggaaccctc ctccatcttt tttgcaacat ctcatttctt   2340

ccttttgctg ttgcttcccc cctcacacac ttggttttgt tctatcctac atttgagatt   2400

tctattttat gttgaacttg ctgctttttt tcatattgaa aagatgacat cgccccaaga   2460

gccaaaaata aatgggaatt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa              2510


<210>  1447
<211>  444
<212>  PRT
<213>  Homosapiens

<400>  1447

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Asp Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Val Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Val Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Glu Asp Phe Gly Glu Glu Ala Glu Glu Glu Ala 
        435                 440                 


<210>  1448
<211>  1839
<212>  DNA
<213>  Homosapiens

<400>  1448
agcaacgggg tgcggcaggg tggggaacgc gggagcgggg ccagctccca ggaaagctgg     60

tctgcgagcg gcccctgccc ggctcccagg tccctgcgcg accccgccct tcccgagacc    120

ccagccgggc tgccgcccgc gtcccggaag ctccagcctg aaccatgttt ttcacttgtg    180

gcccaaatga ggccatggtg gtctccgggt tctgccgaag ccccccagtc atggtggctg    240

gagggcgtgt ctttgtcctg ccctgcatcc aacagatcca gaggatctct ctcaacacac    300

tgaccctcaa tgtcaagagt gaaaaggttt acactcgcca tggggtcccc atctcagtca    360

ctggcattgc ccaggtaaaa atccaggggc agaacaagga gatgttggcg gccgcctgtc    420

agatgttcct ggggaagacg gaggctgaga ttgcccacat tgccctggag acgttagagg    480

gccaccagag ggccatcatg gcccacatga ctgtggagga gatctataag gacaggcaga    540

aattctcaga acaggttttc aaagtggcct cctcagacct ggtcaacatg ggcatcagtg    600

tggttagcta cactctgaag gacattcacg atgaccagga ctatttgcac tctttgggga    660

aggctcgaac agctcaagtc caaaaagatg cacggattgg agaagcagag gccaagagag    720

atgctgggat ccgggaagct aaagccaagc aggaaaaggt gtctgctcag tacctgagtg    780

agatcgagat ggccaaggca cagagagatt acgaactgaa gaaggccgcc tatgacatcg    840

aggtcaacac ccgccgagca caggctgacc tggcctatca gcttcaggtg gccaagacta    900

agcagcagat tgaggagcag cgggtgcagg tgcaggtggt ggagcgggcc cagcaggtgg    960

cagtgcagga gcaggagatc gcccggcggg agaaggagct ggaggcccgg gtgcggaagc   1020

cagcggaagc ggagcgctac aagctggagc gcctagccga ggcagagaag tcccaactaa   1080

ttatgcaggc ggaggcagaa gccgcgtctg tgcggatgcg tggggaagct gaggcctttg   1140

ccataggggc ccgagcccga gccgaggctg agcagatggc caagaaggca gaagccttcc   1200

agctgtacca agaggctgct cagctggaca tgctgctaga gaagctgccc caggtggcag   1260

aggagatcag tggtcccttg acttcagcca ataagatcac actggtgtcc agcggcagtg   1320

ggaccatggg ggcagccaaa gtgactgggg aagtactgga cattctaact cgcctgccag   1380

agagtgtgga aagactcaca ggcgtgagca tctcccaggt gaatcacaag cctttgagaa   1440

cagcctgagc cttcagccct cacagatgcc cagcctcata gctgaagttg cctgaatgat   1500

cctcctgttg catgtaaccc actggcctcc ctgagcatgt ccattgacag tgaggtccca   1560

cccctcatct ctccttgcca aatagtttgt gccttgtctt gaagggggtt gctccccttg   1620

ccaacctcac actgctatga ttgccaactc cagcggtccc atgtcagcct tctgatgatc   1680

ccactccacc ccacctcaac ttatttaact tcctaattaa atcagactgt ttgagcctgt   1740

tgtctagaat attttcctga ccaagactga gggatgggct ggaggttttc aactttgcta   1800

cccaaataaa ttgctgtaag taagtactaa aaaaaaaaa                          1839


<210>  1449
<211>  427
<212>  PRT
<213>  Homosapiens

<400>  1449

Met Phe Phe Thr Cys Gly Pro Asn Glu Ala Met Val Val Ser Gly Phe 
1               5                   10                  15      


Cys Arg Ser Pro Pro Val Met Val Ala Gly Gly Arg Val Phe Val Leu 
            20                  25                  30          


Pro Cys Ile Gln Gln Ile Gln Arg Ile Ser Leu Asn Thr Leu Thr Leu 
        35                  40                  45              


Asn Val Lys Ser Glu Lys Val Tyr Thr Arg His Gly Val Pro Ile Ser 
    50                  55                  60                  


Val Thr Gly Ile Ala Gln Val Lys Ile Gln Gly Gln Asn Lys Glu Met 
65                  70                  75                  80  


Leu Ala Ala Ala Cys Gln Met Phe Leu Gly Lys Thr Glu Ala Glu Ile 
                85                  90                  95      


Ala His Ile Ala Leu Glu Thr Leu Glu Gly His Gln Arg Ala Ile Met 
            100                 105                 110         


Ala His Met Thr Val Glu Glu Ile Tyr Lys Asp Arg Gln Lys Phe Ser 
        115                 120                 125             


Glu Gln Val Phe Lys Val Ala Ser Ser Asp Leu Val Asn Met Gly Ile 
    130                 135                 140                 


Ser Val Val Ser Tyr Thr Leu Lys Asp Ile His Asp Asp Gln Asp Tyr 
145                 150                 155                 160 


Leu His Ser Leu Gly Lys Ala Arg Thr Ala Gln Val Gln Lys Asp Ala 
                165                 170                 175     


Arg Ile Gly Glu Ala Glu Ala Lys Arg Asp Ala Gly Ile Arg Glu Ala 
            180                 185                 190         


Lys Ala Lys Gln Glu Lys Val Ser Ala Gln Tyr Leu Ser Glu Ile Glu 
        195                 200                 205             


Met Ala Lys Ala Gln Arg Asp Tyr Glu Leu Lys Lys Ala Ala Tyr Asp 
    210                 215                 220                 


Ile Glu Val Asn Thr Arg Arg Ala Gln Ala Asp Leu Ala Tyr Gln Leu 
225                 230                 235                 240 


Gln Val Ala Lys Thr Lys Gln Gln Ile Glu Glu Gln Arg Val Gln Val 
                245                 250                 255     


Gln Val Val Glu Arg Ala Gln Gln Val Ala Val Gln Glu Gln Glu Ile 
            260                 265                 270         


Ala Arg Arg Glu Lys Glu Leu Glu Ala Arg Val Arg Lys Pro Ala Glu 
        275                 280                 285             


Ala Glu Arg Tyr Lys Leu Glu Arg Leu Ala Glu Ala Glu Lys Ser Gln 
    290                 295                 300                 


Leu Ile Met Gln Ala Glu Ala Glu Ala Ala Ser Val Arg Met Arg Gly 
305                 310                 315                 320 


Glu Ala Glu Ala Phe Ala Ile Gly Ala Arg Ala Arg Ala Glu Ala Glu 
                325                 330                 335     


Gln Met Ala Lys Lys Ala Glu Ala Phe Gln Leu Tyr Gln Glu Ala Ala 
            340                 345                 350         


Gln Leu Asp Met Leu Leu Glu Lys Leu Pro Gln Val Ala Glu Glu Ile 
        355                 360                 365             


Ser Gly Pro Leu Thr Ser Ala Asn Lys Ile Thr Leu Val Ser Ser Gly 
    370                 375                 380                 


Ser Gly Thr Met Gly Ala Ala Lys Val Thr Gly Glu Val Leu Asp Ile 
385                 390                 395                 400 


Leu Thr Arg Leu Pro Glu Ser Val Glu Arg Leu Thr Gly Val Ser Ile 
                405                 410                 415     


Ser Gln Val Asn His Lys Pro Leu Arg Thr Ala 
            420                 425         


<210>  1450
<211>  1236
<212>  DNA
<213>  Homosapiens

<400>  1450
acttggcctt acactccgct cggctcacca tgtgtcactc tcgcagctgc cacccgacca     60

tgaccatcct gcaggccccg accccggccc cctccaccat cccgggaccc cggcggggct    120

ccggtcctga gatcttcacc ttcgaccctc tcccggagcc cgcagcggcc cctgccgggc    180

gccccagcgc ctctcgcggg caccgaaagc gcagccgcag ggttctctac cctcgagtgg    240

tccggcgcca gctgccagtc gaggaaccga acccagccaa aaggcttctc tttctgctgc    300

tcaccatcgt cttctgccag atcctgatgg ctgaagaggg tgtgccggcg cccctgcctc    360

cagaggacgc ccctaacgcc gcatccctgg cgcccacccc tgtgtccccc gtcctcgagc    420

cctttaatct gacttcggag ccctcggact acgctctgga cctcagcact ttcctccagc    480

aacacccggc cgccttctaa ctgtgactcc ccgcactccc caaaaagaat ccgaaaaacc    540

acaaagaaac accaggcgta cctggtgcgc gagagcgtat ccccaactgg gacttccgag    600

gcaacttgaa ctcagaacac tacagcggag acgccacccg gtgcttgagg cgggaccgag    660

gcgcacagag accgaggcgc atagagaccg aggcacagcc cagctggggc taggcccggt    720

gggaaggaga gcgtcgttaa tttatttctt attgctccta attaatattt atatgtattt    780

atgtacgtcc tcctaggtga tggagatgtg tacgtaatat ttattttaac ttatgcaagg    840

gtgtgagatg ttccccctgc tgtaaatgca ggtctcttgg tatttattga gctttgtggg    900

actggtggaa gcaggacacc tggaactgcg gcaaagtagg agaagaaatg gggaggactc    960

gggtggggga ggacgtcccg gctgggatga agtctggtgg tgggtcgtaa gtttaggagg   1020

tgactgcatc ctccagcatc tcaactccgt ctgtctactg tgtgagactt cggcggacca   1080

ttaggaatga gatccgtgag atccttccat cttcttgaag tcgcctttag ggtggctacg   1140

aggtagaggg gtgggggttg gtgggctgtc acggagcgac tgtcgagatc gcctagtatg   1200

ttctgtgaac acaaataaaa ttgatttact gtctgc                             1236


<210>  1451
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  1451

Met Cys His Ser Arg Ser Cys His Pro Thr Met Thr Ile Leu Gln Ala 
1               5                   10                  15      


Pro Thr Pro Ala Pro Ser Thr Ile Pro Gly Pro Arg Arg Gly Ser Gly 
            20                  25                  30          


Pro Glu Ile Phe Thr Phe Asp Pro Leu Pro Glu Pro Ala Ala Ala Pro 
        35                  40                  45              


Ala Gly Arg Pro Ser Ala Ser Arg Gly His Arg Lys Arg Ser Arg Arg 
    50                  55                  60                  


Val Leu Tyr Pro Arg Val Val Arg Arg Gln Leu Pro Val Glu Glu Pro 
65                  70                  75                  80  


Asn Pro Ala Lys Arg Leu Leu Phe Leu Leu Leu Thr Ile Val Phe Cys 
                85                  90                  95      


Gln Ile Leu Met Ala Glu Glu Gly Val Pro Ala Pro Leu Pro Pro Glu 
            100                 105                 110         


Asp Ala Pro Asn Ala Ala Ser Leu Ala Pro Thr Pro Val Ser Pro Val 
        115                 120                 125             


Leu Glu Pro Phe Asn Leu Thr Ser Glu Pro Ser Asp Tyr Ala Leu Asp 
    130                 135                 140                 


Leu Ser Thr Phe Leu Gln Gln His Pro Ala Ala Phe 
145                 150                 155     


<210>  1452
<211>  1345
<212>  DNA
<213>  Homosapiens

<400>  1452
acttggcctt acactccgct cggctcacca tgtgtcactc tcgcagctgc cacccgacca     60

tgaccatcct gcaggccccg accccggccc cctccaccat cccgggaccc cggcggggct    120

ccggtcctga gatcttcacc ttcgaccctc tcccggagcc cgcagcggcc cctgccgggc    180

gccccagcgc ctctcgcggg caccgaaagc gcagccgcag ggtctctcta ccctcgagtg    240

gtgagtatcg ccgaagtggg cattcgcggt gtgcgctgcc ctggagtcac tggggaacga    300

cccgactcca gagcctcgac ctgacctgtc tcctgttttg tctcccctta gtccggcgcc    360

agctgccagt cgaggaaccg aacccagcca aaaggcttct ctttctgctg ctcaccatcg    420

tcttctgcca gatcctgatg gctgaagagg gtgtgccggc gcccctgcct ccagaggacg    480

cccctaacgc cgcatccctg gcgcccaccc ctgtgtcccc cgtcctcgag ccctttaatc    540

tgacttcgga gccctcggac tacgctctgg acctcagcac tttcctccag caacacccgg    600

ccgccttcta actgtgactc cccgcactcc ccaaaaagaa tccgaaaaac cacaaagaaa    660

caccaggcgt acctggtgcg cgagagcgta tccccaactg ggacttccga ggcaacttga    720

actcagaaca ctacagcgga gacgccaccc ggtgcttgag gcgggaccga ggcgcacaga    780

gaccgaggcg catagagacc gaggcacagc ccagctgggc taggccggtg ggaaggagag    840

cgtcgttaat ttatttctta ttgctcctaa ttaatattta tatgtattta tgtacgtcct    900

cctaggtgat ggagatgtgt acgtaatatt tattttaact tatgcaaggg tgtgagatgt    960

tccctctgct gtaaatgcag gtctcttggt atttattgag ctttgtggga ctggtggaag   1020

caggacacct ggaactgcgg caaagtagga gaagaaatgg ggaggactcg ggtgggggag   1080

gacgtcccgg ctgggatgaa gtctggtggt gggtcgtaag tttaggaggt gactgcatcc   1140

tccagcatct caactccgtc tgtctactgt gtgagacttc ggcggaccat taggaatgag   1200

atccgtgaga tccttccatc ttcttgaagt cgcctttagg gtggctgcga ggtagagggt   1260

tgggggttgg tgggctgtca cggagcgact gtcgagatcg cctagtatgt tctgtgaaca   1320

caaataaaat tgatttactg tctgc                                         1345


<210>  1453
<211>  193
<212>  PRT
<213>  Homosapiens

<400>  1453

Met Cys His Ser Arg Ser Cys His Pro Thr Met Thr Ile Leu Gln Ala 
1               5                   10                  15      


Pro Thr Pro Ala Pro Ser Thr Ile Pro Gly Pro Arg Arg Gly Ser Gly 
            20                  25                  30          


Pro Glu Ile Phe Thr Phe Asp Pro Leu Pro Glu Pro Ala Ala Ala Pro 
        35                  40                  45              


Ala Gly Arg Pro Ser Ala Ser Arg Gly His Arg Lys Arg Ser Arg Arg 
    50                  55                  60                  


Val Ser Leu Pro Ser Ser Gly Glu Tyr Arg Arg Ser Gly His Ser Arg 
65                  70                  75                  80  


Cys Ala Leu Pro Trp Ser His Trp Gly Thr Thr Arg Leu Gln Ser Leu 
                85                  90                  95      


Asp Leu Thr Cys Leu Leu Phe Cys Leu Pro Leu Val Arg Arg Gln Leu 
            100                 105                 110         


Pro Val Glu Glu Pro Asn Pro Ala Lys Arg Leu Leu Phe Leu Leu Leu 
        115                 120                 125             


Thr Ile Val Phe Cys Gln Ile Leu Met Ala Glu Glu Gly Val Pro Ala 
    130                 135                 140                 


Pro Leu Pro Pro Glu Asp Ala Pro Asn Ala Ala Ser Leu Ala Pro Thr 
145                 150                 155                 160 


Pro Val Ser Pro Val Leu Glu Pro Phe Asn Leu Thr Ser Glu Pro Ser 
                165                 170                 175     


Asp Tyr Ala Leu Asp Leu Ser Thr Phe Leu Gln Gln His Pro Ala Ala 
            180                 185                 190         


Phe 
    


<210>  1454
<211>  3840
<212>  DNA
<213>  Homosapiens

<400>  1454
gtcttcccct cgtgggccct gagcgggact gcagccagcc ccctggggcg ccagctttgg     60

aggcccccga cagctgctct cgggagccgc ctcccgacac ccgagccccg ccggcgcctc    120

ccgctcccgg ctcccggctc ctggctccct ccgcctcccc cgcccctcgc cccgccgccg    180

aagaggcccc gctcccgggt cggacgcctg ggtctgccgg gaagagcgat gagaggtgtc    240

tgaaggtggc tattcactga gcgatggggt tggacttgaa ggaatgccaa gagatgctgc    300

ccccaccccc ttaggcccga gggatcagga gctatgggac cagaggccct gtcatcttta    360

ctgctgctgc tcttggtggc aagtggagat gctgacatga agggacattt tgatcctgcc    420

aagtgccgct atgccctggg catgcaggac cggaccatcc cagacagtga catctctgct    480

tccagctcct ggtcagattc cactgccgcc cgccacagca ggttggagag cagtgacggg    540

gatggggcct ggtgccccgc agggtcggtg tttcccaagg aggaggagta cttgcaggtg    600

gatctacaac gactgcacct ggtggctctg gtgggcaccc agggacggca tgccgggggc    660

ctgggcaagg agttctcccg gagctaccgg ctgcgttact cccgggatgg tcgccgctgg    720

atgggctgga aggaccgctg gggtcaggag gtgatctcag gcaatgagga ccctgaggga    780

gtggtgctga aggaccttgg gccccccatg gttgcccgac tggttcgctt ctacccccgg    840

gctgaccggg tcatgagcgt ctgtctgcgg gtagagctct atggctgcct ctggagggat    900

ggactcctgt cttacactgc ccctgtgggg cagacaatgt atttatctga ggccgtgtac    960

ctcaacgact ccacctatga cggacatacc gtgggcggac tgcagtatgg gggtctgggc   1020

cagctggcag atggtgtggt ggggctggat gactttagga agagtcagga gctgcgggtc   1080

tggccaggct atgactatgt gggatggagc aaccacagct tctccagtgg ctatgtggag   1140

atggagtttg agtttgaccg gctgagggcc ttccaggcta tgcaggtcca ctgtaacaac   1200

atgcacacgc tgggagcccg tctgcctggc ggggtggaat gtcgcttccg gcgtggccct   1260

gccatggcct gggaggggga gcccatgcgc cacaacctag ggggcaacct gggggacccc   1320

agagcccggg ctgtctcagt gccccttggc ggccgtgtgg ctcgctttct gcagtgccgc   1380

ttcctctttg cggggccctg gttactcttc agcgaaatct ccttcatctc tgatgtggtg   1440

aacaattcct ctccggcact gggaggcacc ttcccgccag ccccctggtg gccgcctggc   1500

ccacctccca ccaacttcag cagcttggag ctggagccca gaggccagca gcccgtggcc   1560

aaggccgagg ggagcccgac cgccatcctc atcggctgcc tggtggccat catcctgctc   1620

ctgctgctca tcattgccct catgctctgg cggctgcact ggcgcaggct cctcagcaag   1680

gctgaacgga gggtgttgga agaggagctg acggttcacc tctctgtccc tggggacact   1740

atcctcatca acaaccgccc aggtcctaga gagccacccc cgtaccagga gccccggcct   1800

cgtgggaatc cgccccactc cgctccctgt gtccccaatg gctctgccta cagtggggac   1860

tatatggagc ctgagaagcc aggcgccccg cttctgcccc cacctcccca gaacagcgtc   1920

ccccattatg ccgaggctga cattgttacc ctgcagggcg tcaccggggg caacacctat   1980

gctgtgcctg cactgccccc aggggcagtc ggggatgggc cccccagagt ggatttccct   2040

cgatctcgac tccgcttcaa ggagaagctt ggcgagggcc agtttgggga ggtgcacctg   2100

tgtgaggtcg acagccctca agatctggtt agtcttgatt tcccccttaa tgtgcgtaag   2160

ggacaccctt tgctggtagc tgtcaagatc ttacggccag atgccaccaa gaatgccagg   2220

aatgatttcc tgaaagaggt gaagatcatg tcgaggctca aggacccaaa catcattcgg   2280

ctgctgggcg tgtgtgtgca ggacgacccc ctctgcatga ttactgacta catggagaac   2340

ggcgacctca accagttcct cagtgcccac cagctggagg acaaggcagc cgagggggcc   2400

cctggggacg ggcaggctgc gcaggggccc accatcagct acccaatgct gctgcatgtg   2460

gcagcccaga tcgcctccgg catgcgctat ctggccacac tcaactttgt acatcgggac   2520

ctggccacgc ggaactgcct agttggggaa aatttcacca tcaaaatcgc agactttggc   2580

atgagccgga acctctatgc tggggactat taccgtgtgc agggccgggc agtgctgccc   2640

atccgctgga tggcctggga gtgcatcctc atggggaagt tcacgactgc gagtgacgtg   2700

tgggcctttg gtgtgaccct gtgggaggtg ctgatgctct gtagggccca gccctttggg   2760

cagctcaccg acgagcaggt catcgagaac gcgggggagt tcttccggga ccagggccgg   2820

caggtgtacc tgtcccggcc gcctgcctgc ccgcagggcc tatatgagct gatgcttcgg   2880

tgctggagcc gggagtctga gcagcgacca cccttttccc agctgcatcg gttcctggca   2940

gaggatgcac tcaacacggt gtgaatcaca catccagctg cccctccctc agggagcgat   3000

ccaggggaag ccagtgacac taaaacaaga ggacacaatg gcacctctgc ccttcccctc   3060

ccgacagccc atcacctcta atagaggcag tgagactgca ggtgggctgg gcccacccag   3120

ggagctgatg ccccttctcc ccttcctgga cacactctca tgtccccttc ctgttcttcc   3180

ttcctagaag cccctgtcgc ccacccagct ggtcctgtgg atgggatcct ctccaccctc   3240

ctctagccat cccttgggga agggtgggga gaaatatagg atagacactg gacatggccc   3300

attggagcac ctgggcccca ctggacaaca ctgattcctg gagaggtggc tgcgccccca   3360

gcttctctct ccctgtcaca cactggaccc cactggctga gaatctgggg gtgaggagga   3420

caagaaggag aggaaaatgt ttccttgtgc ctgctcctgt acttgtcctc agcttgggct   3480

tcttcctcct ccatcacctg aaacactgga cctgggggta gccccgcccc agccctcagt   3540

cacccccact tcccacttgc agtcttgtag ctagaacttc tctaagccta tacgtttctg   3600

tggagtaaat attgggattg gggggaaaga gggagcaacg gcccatagcc ttggggttgg   3660

acatctctag tgtagctgcc acattgattt ttctataatc acttggggtt tgtacatttt   3720

tggggggaga gacacagatt tttacactaa tatatggacc tagcttgagg caattttaat   3780

cccctgcact aggcaggtaa taataaaggt tgagttttcc acaaaaaaaa aaaaaaaaaa   3840


<210>  1455
<211>  876
<212>  PRT
<213>  Homosapiens

<400>  1455

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Tyr Ser Gly Asp Tyr Met Glu 
            500                 505                 510         


Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro Pro Pro Gln Asn Ser 
        515                 520                 525             


Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr Leu Gln Gly Val Thr 
    530                 535                 540                 


Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro Pro Gly Ala Val Gly 
545                 550                 555                 560 


Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser Arg Leu Arg Phe Lys 
                565                 570                 575     


Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val His Leu Cys Glu Val 
            580                 585                 590         


Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe Pro Leu Asn Val Arg 
        595                 600                 605             


Lys Gly His Pro Leu Leu Val Ala Val Lys Ile Leu Arg Pro Asp Ala 
    610                 615                 620                 


Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser 
625                 630                 635                 640 


Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln 
                645                 650                 655     


Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu 
            660                 665                 670         


Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp Lys Ala Ala Glu Gly 
        675                 680                 685             


Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro Thr Ile Ser Tyr Pro 
    690                 695                 700                 


Met Leu Leu His Val Ala Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu 
705                 710                 715                 720 


Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu 
                725                 730                 735     


Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg 
            740                 745                 750         


Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu 
        755                 760                 765             


Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr 
    770                 775                 780                 


Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu 
785                 790                 795                 800 


Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val 
                805                 810                 815     


Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr 
            820                 825                 830         


Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu Tyr Glu Leu Met Leu 
        835                 840                 845             


Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro Pro Phe Ser Gln Leu 
    850                 855                 860                 


His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr Val 
865                 870                 875     


<210>  1456
<211>  3877
<212>  DNA
<213>  Homosapiens

<400>  1456
tgctctcggg agccgcctcc cgacacccga gccccgccgg cgcctcccgc tcccggctcc     60

cggctcctgg ctccctccgc ctcccccgcc cctcgccccg ccgccgaaga ggccccgctc    120

ccgggtcgga cgcctgggtc tgccgggaag agcgatgaga ggtgtctgaa ggtggctatt    180

cactgagcga tggggttgga cttgaaggaa tgccaagaga tgctgccccc acccccttag    240

gcccgaggga tcaggagcta tgggaccaga ggccctgtca tctttactgc tgctgctctt    300

ggtggcaagt ggagatgctg acatgaaggg acattttgat cctgccaagt gccgctatgc    360

cctgggcatg caggaccgga ccatcccaga cagtgacatc tctgcttcca gctcctggtc    420

agattccact gccgcccgcc acagcaggtt ggagagcagt gacggggatg gggcctggtg    480

ccccgcaggg tcggtgtttc ccaaggagga ggagtacttg caggtggatc tacaacgact    540

gcacctggtg gctctggtgg gcacccaggg acggcatgcc gggggcctgg gcaaggagtt    600

ctcccggagc taccggctgc gttactcccg ggatggtcgc cgctggatgg gctggaagga    660

ccgctggggt caggaggtga tctcaggcaa tgaggaccct gagggagtgg tgctgaagga    720

ccttgggccc cccatggttg cccgactggt tcgcttctac ccccgggctg accgggtcat    780

gagcgtctgt ctgcgggtag agctctatgg ctgcctctgg agggatggac tcctgtctta    840

caccgcccct gtggggcaga caatgtattt atctgaggcc gtgtacctca acgactccac    900

ctatgacgga cataccgtgg gcggactgca gtatgggggt ctgggccagc tggcagatgg    960

tgtggtgggg ctggatgact ttaggaagag tcaggagctg cgggtctggc caggctatga   1020

ctatgtggga tggagcaacc acagcttctc cagtggctat gtggagatgg agtttgagtt   1080

tgaccggctg agggccttcc aggctatgca ggtccactgt aacaacatgc acacgctggg   1140

agcccgtctg cctggcgggg tggaatgtcg cttccggcgt ggccctgcca tggcctggga   1200

gggggagccc atgcgccaca acctaggggg caacctgggg gaccccagag cccgggctgt   1260

ctcagtgccc cttggcggcc gtgtggctcg ctttctgcag tgccgcttcc tctttgcggg   1320

gccctggtta ctcttcagcg aaatctcctt catctctgat gtggtgaaca attcctctcc   1380

ggcactggga ggcaccttcc cgccagcccc ctggtggccg cctggcccac ctcccaccaa   1440

cttcagcagc ttggagctgg agcccagagg ccagcagccc gtggccaagg ccgaggggag   1500

cccgaccgcc atcctcatcg gctgcctggt ggccatcatc ctgctcctgc tgctcatcat   1560

tgccctcatg ctctggcggc tgcactggcg caggctcctc agcaaggctg aacggagggt   1620

gttggaagag gagctgacgg ttcacctctc tgtccctggg gacactatcc tcatcaacaa   1680

ccgcccaggt cctagagagc cacccccgta ccaggagccc cggcctcgtg ggaatccgcc   1740

ccactccgct ccctgtgtcc ccaatggctc tgcgttgctg ctctccaatc cagcctaccg   1800

cctccttctg gccacttacg cccgtccccc tcgaggcccg ggccccccca cacccgcctg   1860

ggccaaaccc accaacaccc aggcctacag tggggactat atggagcctg agaagccagg   1920

cgccccgctt ctgcccccac ctccccagaa cagcgtcccc cattatgccg aggctgacat   1980

tgttaccctg cagggcgtca ccgggggcaa cacctatgct gtgcctgcac tgcccccagg   2040

ggcagtcggg gatgggcccc ccagagtgga tttccctcga tctcgactcc gcttcaagga   2100

gaagcttggc gagggccagt ttggggaggt gcacctgtgt gaggtcgaca gccctcaaga   2160

tctggttagt cttgatttcc cccttaatgt gcgtaaggga caccctttgc tggtagctgt   2220

caagatctta cggccagatg ccaccaagaa tgccaggaat gatttcctga aagaggtgaa   2280

gatcatgtcg aggctcaagg acccaaacat cattcggctg ctgggcgtgt gtgtgcagga   2340

cgaccccctc tgcatgatta ctgactacat ggagaacggc gacctcaacc agttcctcag   2400

tgcccaccag ctggaggaca aggcagccga gggggcccct ggggacgggc aggctgcgca   2460

ggggcccacc atcagctacc caatgctgct gcatgtggca gcccagatcg cctccggcat   2520

gcgctatctg gccacactca actttgtaca tcgggacctg gccacgcgga actgcctagt   2580

tggggaaaat ttcaccatca aaatcgcaga ctttggcatg agccggaacc tctatgctgg   2640

ggactattac cgtgtgcagg gccgggcagt gctgcccatc cgctggatgg cctgggagtg   2700

catcctcatg gggaagttca cgactgcgag tgacgtgtgg gcctttggtg tgaccctgtg   2760

ggaggtgctg atgctctgta gggcccagcc ctttgggcag ctcaccgacg agcaggtcat   2820

cgagaacgcg ggggagttct tccgggacca gggccggcag gtgtacctgt cccggccgcc   2880

tgcctgcccg cagggcctat atgagctgat gcttcggtgc tggagccggg agtctgagca   2940

gcgaccaccc ttttcccagc tgcatcggtt cctggcagag gatgcactca acacggtgtg   3000

aatcacacat ccagctgccc ctccctcagg gagcgatcca ggggaagcca gtgacactaa   3060

aacaagagga cacaatggca cctctgccct tcccctcccg acagcccatc acctctaata   3120

gaggcagtga gactgcaggt gggctgggcc cacccaggga gctgatgccc cttctcccct   3180

tcctggacac actctcatgt ccccttcctg ttcttccttc ctagaagccc ctgtcgccca   3240

cccagctggt cctgtggatg ggatcctctc caccctcctc tagccatccc ttggggaagg   3300

gtggggagaa atataggata gacactggac atggcccatt ggagcacctg ggccccactg   3360

gacaacactg attcctggag aggtggctgc gcccccagct tctctctccc tgtcacacac   3420

tggaccccac tggctgagaa tctgggggtg aggaggacaa gaaggagagg aaaatgtttc   3480

cttgtgcctg ctcctgtact tgtcctcagc ttgggcttct tcctcctcca tcacctgaaa   3540

cactggacct gggggtagcc ccgccccagc cctcagtcac ccccacttcc cacttgcagt   3600

cttgtagcta gaacttctct aagcctatac gtttctgtgg agtaaatatt gggattgggg   3660

ggaaagaggg agcaacggcc catagccttg gggttggaca tctctagtgt agctgccaca   3720

ttgatttttc tataatcact tggggtttgt acatttttgg ggggagagac acagattttt   3780

acactaatat atggacctag cttgaggcaa ttttaatccc ctgcactagg caggtaataa   3840

taaaggttga gttttccaca aaaaaaaaaa aaaaaaa                            3877


<210>  1457
<211>  913
<212>  PRT
<213>  Homosapiens

<400>  1457

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         


Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             


Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 


Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         


Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             


Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 


His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe 
625                 630                 635                 640 


Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     


Leu Arg Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu 
            660                 665                 670         


Val Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu 
        675                 680                 685             


Gly Val Cys Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met 
    690                 695                 700                 


Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp 
705                 710                 715                 720 


Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro 
                725                 730                 735     


Thr Ile Ser Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser 
            740                 745                 750         


Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala 
        755                 760                 765             


Thr Arg Asn Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp 
    770                 775                 780                 


Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln 
785                 790                 795                 800 


Gly Arg Ala Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu 
                805                 810                 815     


Met Gly Lys Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr 
            820                 825                 830         


Leu Trp Glu Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu 
        835                 840                 845             


Thr Asp Glu Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln 
    850                 855                 860                 


Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu 
865                 870                 875                 880 


Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro 
                885                 890                 895     


Pro Phe Ser Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr 
            900                 905                 910         


Val 
    


<210>  1458
<211>  3678
<212>  DNA
<213>  Homosapiens

<400>  1458
agatgctgcc cccaccccct taggcccgag ggatcaggag ctatgggacc agaggccctg     60

tcatctttac tgctgctgct cttggtggca agtggagatg ctgacatgaa gggacatttt    120

gatcctgcca agtgccgcta tgccctgggc atgcaggacc ggaccatccc agacagtgac    180

atctctgctt ccagctcctg gtcagattcc actgccgccc gccacagcag gttggagagc    240

agtgacgggg atggggcctg gtgccccgca gggtcggtgt ttcccaagga ggaggagtac    300

ttgcaggtgg atctacaacg actgcacctg gtggctctgg tgggcaccca gggacggcat    360

gccgggggcc tgggcaagga gttctcccgg agctaccggc tgcgttactc ccgggatggt    420

cgccgctgga tgggctggaa ggaccgctgg ggtcaggagg tgatctcagg caatgaggac    480

cctgagggag tggtgctgaa ggaccttggg ccccccatgg ttgcccgact ggttcgcttc    540

tacccccggg ctgaccgggt catgagcgtc tgtctgcggg tagagctcta tggctgcctc    600

tggagggatg gactcctgtc ttacaccgcc cctgtggggc agacaatgta tttatctgag    660

gccgtgtacc tcaacgactc cacctatgac ggacataccg tgggcggact gcagtatggg    720

ggtctgggcc agctggcaga tggtgtggtg gggctggatg actttaggaa gagtcaggag    780

ctgcgggtct ggccaggcta tgactatgtg ggatggagca accacagctt ctccagtggc    840

tatgtggaga tggagtttga gtttgaccgg ctgagggcct tccaggctat gcaggtccac    900

tgtaacaaca tgcacacgct gggagcccgt ctgcctggcg gggtggaatg tcgcttccgg    960

cgtggccctg ccatggcctg ggagggggag cccatgcgcc acaacctagg gggcaacctg   1020

ggggacccca gagcccgggc tgtctcagtg ccccttggcg gccgtgtggc tcgctttctg   1080

cagtgccgct tcctctttgc ggggccctgg ttactcttca gcgaaatctc cttcatctct   1140

gatgtggtga acaattcctc tccggcactg ggaggcacct tcccgccagc cccctggtgg   1200

ccgcctggcc cacctcccac caacttcagc agcttggagc tggagcccag aggccagcag   1260

cccgtggcca aggccgaggg gagcccgacc gccatcctca tcggctgcct ggtggccatc   1320

atcctgctcc tgctgctcat cattgccctc atgctctggc ggctgcactg gcgcaggctc   1380

ctcagcaagg ctgaacggag ggtgttggaa gaggagctga cggttcacct ctctgtccct   1440

ggggacacta tcctcatcaa caaccgccca ggtcctagag agccaccccc gtaccaggag   1500

ccccggcctc gtgggaatcc gccccactcc gctccctgtg tccccaatgg ctctgcgttg   1560

ctgctctcca atccagccta ccgcctcctt ctggccactt acgcccgtcc ccctcgaggc   1620

ccgggccccc ccacacccgc ctgggccaaa cccaccaaca cccaggccta cagtggggac   1680

tatatggagc ctgagaagcc aggcgccccg cttctgcccc cacctcccca gaacagcgtc   1740

ccccattatg ccgaggctga cattgttacc ctgcagggcg tcaccggggg caacacctat   1800

gctgtgcctg cactgccccc aggggcagtc ggggatgggc cccccagagt ggatttccct   1860

cgatctcgac tccgcttcaa ggagaagctt ggcgagggcc agtttgggga ggtgcacctg   1920

tgtgaggtcg acagccctca agatctggtt agtcttgatt tcccccttaa tgtgcgtaag   1980

ggacaccctt tgctggtagc tgtcaagatc ttacggccag atgccaccaa gaatgccagc   2040

ttctccttgt tctccaggaa tgatttcctg aaagaggtga agatcatgtc gaggctcaag   2100

gacccaaaca tcattcggct gctgggcgtg tgtgtgcagg acgaccccct ctgcatgatt   2160

actgactaca tggagaacgg cgacctcaac cagttcctca gtgcccacca gctggaggac   2220

aaggcagccg agggggcccc tggggacggg caggctgcgc aggggcccac catcagctac   2280

ccaatgctgc tgcatgtggc agcccagatc gcctccggca tgcgctatct ggccacactc   2340

aactttgtac atcgggacct ggccacgcgg aactgcctag ttggggaaaa tttcaccatc   2400

aaaatcgcag actttggcat gagccggaac ctctatgctg gggactatta ccgtgtgcag   2460

ggccgggcag tgctgcccat ccgctggatg gcctgggagt gcatcctcat ggggaagttc   2520

acgactgcga gtgacgtgtg ggcctttggt gtgaccctgt gggaggtgct gatgctctgt   2580

agggcccagc cctttgggca gctcaccgac gagcaggtca tcgagaacgc gggggagttc   2640

ttccgggacc agggccggca ggtgtacctg tcccggccgc ctgcctgccc gcagggccta   2700

tatgagctga tgcttcggtg ctggagccgg gagtctgagc agcgaccacc cttttcccag   2760

ctgcatcggt tcctggcaga ggatgcactc aacacggtgt gaatcacaca tccagctgcc   2820

cctccctcag ggagcgatcc aggggaagcc agtgacacta aaacaagagg acacaatggc   2880

acctctgccc ttcccctccc gacagcccat cacctctaat agaggcagtg agactgcagg   2940

tgggctgggc ccacccaggg agctgatgcc ccttctcccc ttcctggaca cactctcatg   3000

tccccttcct gttcttcctt cctagaagcc cctgtcgccc acccagctgg tcctgtggat   3060

gggatcctct ccaccctcct ctagccatcc cttggggaag ggtggggaga aatataggat   3120

agacactgga catggcccat tggagcacct gggccccact ggacaacact gattcctgga   3180

gaggtggctg cgcccccagc ttctctctcc ctgtcacaca ctggacccca ctggctgaga   3240

atctgggggt gaggaggaca agaaggagag gaaaatgttt ccttgtgcct gctcctgtac   3300

ttgtcctcag cttgggcttc ttcctcctcc atcacctgaa acactggacc tgggggtagc   3360

cccgccccag ccctcagtca cccccacttc ccacttgcag tcttgtagct agaacttctc   3420

taagcctata cgtttctgtg gagtaaatat tgggattggg gggaaagagg gagcaacggc   3480

ccatagcctt ggggttggac atctctagtg tagctgccac attgattttt ctataatcac   3540

ttggggtttg tacatttttg gggggagaga cacagatttt tacactaata tatggaccta   3600

gcttgaggca attttaatcc cctgcactag gcaggtaata ataaaggttg agttttccac   3660

aaaaaaaaaa aaaaaaaa                                                 3678


<210>  1459
<211>  919
<212>  PRT
<213>  Homosapiens

<400>  1459

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         


Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             


Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 


Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         


Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             


Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 


His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe 
625                 630                 635                 640 


Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     


Leu Arg Pro Asp Ala Thr Lys Asn Ala Ser Phe Ser Leu Phe Ser Arg 
            660                 665                 670         


Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser Arg Leu Lys Asp Pro 
        675                 680                 685             


Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln Asp Asp Pro Leu Cys 
    690                 695                 700                 


Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser 
705                 710                 715                 720 


Ala His Gln Leu Glu Asp Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly 
                725                 730                 735     


Gln Ala Ala Gln Gly Pro Thr Ile Ser Tyr Pro Met Leu Leu His Val 
            740                 745                 750         


Ala Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe 
        755                 760                 765             


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Phe 
    770                 775                 780                 


Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly 
785                 790                 795                 800 


Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu Pro Ile Arg Trp Met 
                805                 810                 815     


Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr Thr Ala Ser Asp Val 
            820                 825                 830         


Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu Met Leu Cys Arg Ala 
        835                 840                 845             


Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val Ile Glu Asn Ala Gly 
    850                 855                 860                 


Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro 
865                 870                 875                 880 


Ala Cys Pro Gln Gly Leu Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg 
                885                 890                 895     


Glu Ser Glu Gln Arg Pro Pro Phe Ser Gln Leu His Arg Phe Leu Ala 
            900                 905                 910         


Glu Asp Ala Leu Asn Thr Val 
        915                 


<210>  1460
<211>  1736
<212>  DNA
<213>  Homosapiens

<400>  1460
cttttccact cctcccctta cctcccttct cttctgaatt ctccattctg ggctcttgcc     60

tgtgaaatct ttctttgctt tccccatctt ttcctcgcat tttttcacca tctttccctc    120

aatctccagg agccaatgcg agactttggc tccgattaag cgacggcccg agactcgggg    180

tgcgcgagga ggatcgacag agtggtgatg gagagcaccc cttcaagggg actgaaccga    240

gtacacctac aatgcaggaa tctgcaggaa ttcttagggg gcctgagccc tggggtattg    300

gaccgattgt atgggcaccc tgccacatgt ctggctgtct tcagggagct cccatccttg    360

gctaagaact gggtgatgcg gatgctcttt ctggagcagc ctttgccaca ggctgctgta    420

gctctgtggg taaagaagga attcagcaag gctcaggagg aaagtacagg gctgctgagc    480

ggcctccgga tctggcacac acagctgctc ccaggcgggc tccagggcct catcctcaac    540

cccattttcc gccagaacct ccgcattgcc cttctgggtg gggggaaggc ctggtctgat    600

gacacaagtc agctgggacc agacaagcat gcccgggacg ttccctccct tgacaagtac    660

gccgaggagc gatgggaggt ggtcttgcac ttcatggtgg gctcccccag tgcagctgtc    720

agccaggact tggctcagct cctcagccag gctgggctca tgaagagtac tgaacctgga    780

gagccgccct gcattacttc cgctggcttc cagttcctgt tgctggacac cccggctcag    840

ctctggtact ttatgttgca gtatttgcag acagcccaga gccggggcat ggacctggta    900

gagattctct ccttcctctt ccagctcagc ttctctactc tgggcaagga ttactctgtg    960

gaaggtatga gtgattctct gttgaacttc ctgcaacatc tgcgtgagtt tgggcttgtt   1020

ttccagagga agaggaaatc tcggcgttac taccccacac gcctggccat caatctctca   1080

tcaggtgtct ctggagctgg gggcactgtg catcagccag gtttcattgt cgtggaaacc   1140

aattaccgac tgtatgccta cacggagtcg gagctgcaga ttgccctcat tgccctcttc   1200

tctgagatgc tctatcggtt ccccaacatg gtggtggcgc aggtgacccg ggagagtgtg   1260

cagcaggcaa tcgccagtgg catcacagcc cagcagataa tccatttcct aaggacaaga   1320

gcccacccag tgatgctcaa acagacacct gtgctgcccc ccaccatcac cgaccagatc   1380

cggctctggg agctggaaag ggacagactc cggttcactg agggtgtcct gtataaccag   1440

ttcctgtcgc aagtggactt tgagctgctg ctggcccacg cgcgggagct gggcgtgctc   1500

gtgttcgaga actcggccaa gcggctcatg gtggtgaccc cggccgggca cagcgacgtc   1560

aagcgctttt ggaagcggca gaaacatagc tcctgagagc gcgggacttg gacacggacc   1620

tcggcgggcg ggactgggcg gggcggggca tcagaactca ggtgtttttt atttacgcgt   1680

cagggctttt cttgtttaat aaagttatga tagctaaaaa aaaaaaaaaa aaaaaa       1736


<210>  1461
<211>  462
<212>  PRT
<213>  Homosapiens

<400>  1461

Met Glu Ser Thr Pro Ser Arg Gly Leu Asn Arg Val His Leu Gln Cys 
1               5                   10                  15      


Arg Asn Leu Gln Glu Phe Leu Gly Gly Leu Ser Pro Gly Val Leu Asp 
            20                  25                  30          


Arg Leu Tyr Gly His Pro Ala Thr Cys Leu Ala Val Phe Arg Glu Leu 
        35                  40                  45              


Pro Ser Leu Ala Lys Asn Trp Val Met Arg Met Leu Phe Leu Glu Gln 
    50                  55                  60                  


Pro Leu Pro Gln Ala Ala Val Ala Leu Trp Val Lys Lys Glu Phe Ser 
65                  70                  75                  80  


Lys Ala Gln Glu Glu Ser Thr Gly Leu Leu Ser Gly Leu Arg Ile Trp 
                85                  90                  95      


His Thr Gln Leu Leu Pro Gly Gly Leu Gln Gly Leu Ile Leu Asn Pro 
            100                 105                 110         


Ile Phe Arg Gln Asn Leu Arg Ile Ala Leu Leu Gly Gly Gly Lys Ala 
        115                 120                 125             


Trp Ser Asp Asp Thr Ser Gln Leu Gly Pro Asp Lys His Ala Arg Asp 
    130                 135                 140                 


Val Pro Ser Leu Asp Lys Tyr Ala Glu Glu Arg Trp Glu Val Val Leu 
145                 150                 155                 160 


His Phe Met Val Gly Ser Pro Ser Ala Ala Val Ser Gln Asp Leu Ala 
                165                 170                 175     


Gln Leu Leu Ser Gln Ala Gly Leu Met Lys Ser Thr Glu Pro Gly Glu 
            180                 185                 190         


Pro Pro Cys Ile Thr Ser Ala Gly Phe Gln Phe Leu Leu Leu Asp Thr 
        195                 200                 205             


Pro Ala Gln Leu Trp Tyr Phe Met Leu Gln Tyr Leu Gln Thr Ala Gln 
    210                 215                 220                 


Ser Arg Gly Met Asp Leu Val Glu Ile Leu Ser Phe Leu Phe Gln Leu 
225                 230                 235                 240 


Ser Phe Ser Thr Leu Gly Lys Asp Tyr Ser Val Glu Gly Met Ser Asp 
                245                 250                 255     


Ser Leu Leu Asn Phe Leu Gln His Leu Arg Glu Phe Gly Leu Val Phe 
            260                 265                 270         


Gln Arg Lys Arg Lys Ser Arg Arg Tyr Tyr Pro Thr Arg Leu Ala Ile 
        275                 280                 285             


Asn Leu Ser Ser Gly Val Ser Gly Ala Gly Gly Thr Val His Gln Pro 
    290                 295                 300                 


Gly Phe Ile Val Val Glu Thr Asn Tyr Arg Leu Tyr Ala Tyr Thr Glu 
305                 310                 315                 320 


Ser Glu Leu Gln Ile Ala Leu Ile Ala Leu Phe Ser Glu Met Leu Tyr 
                325                 330                 335     


Arg Phe Pro Asn Met Val Val Ala Gln Val Thr Arg Glu Ser Val Gln 
            340                 345                 350         


Gln Ala Ile Ala Ser Gly Ile Thr Ala Gln Gln Ile Ile His Phe Leu 
        355                 360                 365             


Arg Thr Arg Ala His Pro Val Met Leu Lys Gln Thr Pro Val Leu Pro 
    370                 375                 380                 


Pro Thr Ile Thr Asp Gln Ile Arg Leu Trp Glu Leu Glu Arg Asp Arg 
385                 390                 395                 400 


Leu Arg Phe Thr Glu Gly Val Leu Tyr Asn Gln Phe Leu Ser Gln Val 
                405                 410                 415     


Asp Phe Glu Leu Leu Leu Ala His Ala Arg Glu Leu Gly Val Leu Val 
            420                 425                 430         


Phe Glu Asn Ser Ala Lys Arg Leu Met Val Val Thr Pro Ala Gly His 
        435                 440                 445             


Ser Asp Val Lys Arg Phe Trp Lys Arg Gln Lys His Ser Ser 
    450                 455                 460         


<210>  1462
<211>  4070
<212>  DNA
<213>  Homosapiens

<400>  1462
gccagctgct gcgcatgcgc cggccggggc cccgccccca tgcgccgcgc ggctccaggg     60

ccacgttcca gggtcgggtt tggtggattc ctcagtccct gccgccgcgg ggcgccctgg    120

gatagcggcg gggcctcctg gtgagcgcgc gccggggcgg cctccgggaa gtgggagacg    180

ctgcgggtcc tgggcccagg ccttgggatg ggcgggaagg cttggccgcg ccgggctgtg    240

ggcactgcag gaggcccctg tgcaggtgga gatcgccgcg gccctggcgg gactccttgc    300

tggctcttgg gcgcgctgat gcccatcatc tccctgagtt tctgagccct atctctcatg    360

tgtcagtggt caccgccgaa tccagacact ccggccctgt tccggaagag ccctgatatc    420

cgtggctcca tggtgctgtc tgtcgatacc atgcactcta gctctcaagg aggaaaggtt    480

ttgtggaagg gaatagagac ttggaataac agacctgtgc taattagaga caggaaagat    540

ggaacaaggg gagtgaccct tctccacccc catatcctaa tgtgctctct ctctatccag    600

aacagatctc ggcccctttc caaacactcc tgatgcctca tttgcctctc gcctcttttc    660

gaccaccatt ttgggggctg aggcactcac ggggcctccc caggtttcac tccgtttcta    720

cacagtcgga gccccatgga tctcccatct cccggaggaa ccgtgaagcc aaacagaagc    780

gcctgcgaga gaagcaggcg actctggagg ctgagatagc aggggagagc aagtcacctg    840

cagaatccat taaggcctgg aggcctaagg agttagtatt gtatgaaatc cctacgaaac    900

ccggtgaaaa gaaagatgtc tctgggcccc tgcctcctgc atacagcccc cgatatgttg    960

aggctgcctg gtacccgtgg tgggtacgag agggcttctt caaaccagaa tatcaggccc   1020

ggctgcccca agctacaggg gagacctttt ccatgtgtat cccacctccc aatgtcactg   1080

gctccctgca cattggccac gcactcacgg tggccataca ggatgccctc gtgcgctggc   1140

accggatgcg tggggatcaa gtgctgtggg tccctggttc agatcatgca ggaattgcta   1200

cacaagctgt ggtggagaaa caactgtgga aggaacgggg agtgaggaga catgagctga   1260

gccgggaggc cttccttagg gaggtgtggc agtggaagga ggcgaaaggt ggagagatct   1320

gtgagcagct gcgagctctg ggtgcctccc tggactggga tcgagagtgt tttaccatgg   1380

atgttggctc ctcagtggct gtgactgaag cttttgtgcg gctctacaag gcggggttgc   1440

tgtaccggaa ccatcagctt gtcaactggt catgtgcttt aagatcagcc atctcggaca   1500

ttgaggtgga gaaccggccc ctgcctggcc acacacagct tcgactgcct ggctgcccca   1560

cccccgtgtc ttttggcctc ctattttctg ttgccttccc cgtggatgga gagcctgatg   1620

cagaggttgt ggtaggaacc acaaggccag agacgctgcc tggagatgtg gctgtggccg   1680

ttcatccaga cgactcgcga tacacacatc tacacgggcg acagcttcgt caccccttga   1740

tggggcagcc tcttcccctc atcacagact atgctgttca gccacatgtg ggcacggggg   1800

cagtgaaggt gactccagct cacagtcctg ccgatgctga gatgggggcc cgacatggct   1860

tgagcccctt gaatgtcatt gcggaggatg ggaccatgac ctccctctgc ggggactggc   1920

tgcagggtct tcaccggttt gtggcccggg aaaagataat gtctgtgctg agtgaatggg   1980

gcctgttccg gggcctccag aaccacccca tggtactgcc catctgcagc cgttctgggg   2040

atgtgataga atacctgctg aagaaccagt ggtttgtccg ctgccaggaa atgggggccc   2100

gagctgccaa ggctgtggag tcgggggccc tggagctcag tccctccttc caccagaaga   2160

actggcagca ctggttttcc catattgggg actggtgtgt ctcccggcag ctgtggtggg   2220

gccatcagat tccagcctac ctggttgtag aggaccatgc gcagggagaa gaggactgtt   2280

gggtggttgg gcggtcagag gctgaggcca gagaggtagc agcggaactg acagggaggc   2340

caggggcaga gctgaccctg gagagggatc ctgatgtcct agacacatgg ttttcttctg   2400

ccctgttccc cttttctgcc ctgggctggc cccaagagac cccagacctt gctcgtttct   2460

accccctgtc acttttggaa acgggcagcg accttctgct gttctgggtg ggccgcatgg   2520

tcatgttggg gacccagctc acagggcagc tgcccttcag caaggtgctt cttcatccca   2580

tggttcggga caggcagggc cggaagatga gcaagtccct ggggaatgtg ctggacccaa   2640

gagacatcat cagtggggtg gagatgcagg tgctgcagga aaagctgaga agcggaaatt   2700

tggaccctgc agagctggcc attgtggctg cagcacagaa aaaggacttt cctcacggga   2760

tccctgagtg tgggacagat gccctgagat tcacactctg ctcccatgga gttcaggcgg   2820

gcgacttgca cctgtcagtc tctgaggtcc agagctgccg acatttctgc aacaagatct   2880

ggaatgctct tcgctttatc ctcaatgctt taggggagaa atttgtgcca cagcctgctg   2940

aggagctgtc tccctcctcc ccgatggatg cctggatcct gagccgcctt gccctggctg   3000

cccaggagtg tgagcggggc ttcctcaccc gagagctctc gctcgtcact catgccctgc   3060

accacttctg gcttcacaac ctctgtgacg tctacctgga ggctgtgaag cccgtgctgt   3120

ggcactcgcc ccgccccctg gggccccctc aggtcctgtt ctcctgcgct gacctcggcc   3180

tccgcctcct ggccccactg atgcccttcc tggctgaaga gctctggcag aggctgcccc   3240

ccaggcctgg ttgcccccct gcccccagca tctcggttgc cccctacccc agcgcctgca   3300

gcttggagca ctggcgccag ccagagctgg agcggcgctt ctcccgggtc caagaggtcg   3360

tgcaggtgct aagggctctc cgagccacgt accagctcac caaagcccgg ccccgagtgc   3420

tgctgcagag ctcagagcct ggggaccagg gcctcttcga ggccttcttg gagcccctgg   3480

gcaccctggg ctactgtggg gctgtgggcc tgttaccccc aggcgcagca gctccctccg   3540

gctgggccca ggctccactc agtgacacgg ctcaagtcta catggagctg cagggcctgg   3600

tggacccgca gatccagcta cctctgttag ccgcccgaag gtacaagttg cagaagcagc   3660

ttgatagcct cacagccagg accccatcag aaggggaggc agggactcag aggcaacaaa   3720

agctttcttc cctccagctg gaattgtcaa aactggacaa ggcagcctct cacctccagc   3780

agctgatgga tgagcctcca gccccaggga gcccggagct ctaactcatc atccccatca   3840

gttttcctcc ctctcagacc tgtctttgag gacaaacaga tttgtcagct gtcagggtgc   3900

agtgggacgt cagagactat gtggtccatc gccttcattg tgtaaatgag gacacagact   3960

ggcttggtcg cagtgactgt ggtgtccttg agatgctcac attactgccc ggcctgcctc   4020

ccacctggaa gtctgggaat gaggagattg agataaactt ttgaaatccc              4070


<210>  1463
<211>  1063
<212>  PRT
<213>  Homosapiens

<400>  1463

Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 
1               5                   10                  15      


Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 
            20                  25                  30          


Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 
        35                  40                  45              


Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 
    50                  55                  60                  


Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 
65                  70                  75                  80  


Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 
                85                  90                  95      


Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 
            100                 105                 110         


Trp Tyr Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln 
        115                 120                 125             


Ala Arg Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro 
    130                 135                 140                 


Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val 
145                 150                 155                 160 


Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln 
                165                 170                 175     


Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala 
            180                 185                 190         


Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu 
        195                 200                 205             


Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala 
    210                 215                 220                 


Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu 
225                 230                 235                 240 


Asp Trp Asp Arg Glu Cys Phe Thr Met Asp Val Gly Ser Ser Val Ala 
                245                 250                 255     


Val Thr Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly Leu Leu Tyr Arg 
            260                 265                 270         


Asn His Gln Leu Val Asn Trp Ser Cys Ala Leu Arg Ser Ala Ile Ser 
        275                 280                 285             


Asp Ile Glu Val Glu Asn Arg Pro Leu Pro Gly His Thr Gln Leu Arg 
    290                 295                 300                 


Leu Pro Gly Cys Pro Thr Pro Val Ser Phe Gly Leu Leu Phe Ser Val 
305                 310                 315                 320 


Ala Phe Pro Val Asp Gly Glu Pro Asp Ala Glu Val Val Val Gly Thr 
                325                 330                 335     


Thr Arg Pro Glu Thr Leu Pro Gly Asp Val Ala Val Ala Val His Pro 
            340                 345                 350         


Asp Asp Ser Arg Tyr Thr His Leu His Gly Arg Gln Leu Arg His Pro 
        355                 360                 365             


Leu Met Gly Gln Pro Leu Pro Leu Ile Thr Asp Tyr Ala Val Gln Pro 
    370                 375                 380                 


His Val Gly Thr Gly Ala Val Lys Val Thr Pro Ala His Ser Pro Ala 
385                 390                 395                 400 


Asp Ala Glu Met Gly Ala Arg His Gly Leu Ser Pro Leu Asn Val Ile 
                405                 410                 415     


Ala Glu Asp Gly Thr Met Thr Ser Leu Cys Gly Asp Trp Leu Gln Gly 
            420                 425                 430         


Leu His Arg Phe Val Ala Arg Glu Lys Ile Met Ser Val Leu Ser Glu 
        435                 440                 445             


Trp Gly Leu Phe Arg Gly Leu Gln Asn His Pro Met Val Leu Pro Ile 
    450                 455                 460                 


Cys Ser Arg Ser Gly Asp Val Ile Glu Tyr Leu Leu Lys Asn Gln Trp 
465                 470                 475                 480 


Phe Val Arg Cys Gln Glu Met Gly Ala Arg Ala Ala Lys Ala Val Glu 
                485                 490                 495     


Ser Gly Ala Leu Glu Leu Ser Pro Ser Phe His Gln Lys Asn Trp Gln 
            500                 505                 510         


His Trp Phe Ser His Ile Gly Asp Trp Cys Val Ser Arg Gln Leu Trp 
        515                 520                 525             


Trp Gly His Gln Ile Pro Ala Tyr Leu Val Val Glu Asp His Ala Gln 
    530                 535                 540                 


Gly Glu Glu Asp Cys Trp Val Val Gly Arg Ser Glu Ala Glu Ala Arg 
545                 550                 555                 560 


Glu Val Ala Ala Glu Leu Thr Gly Arg Pro Gly Ala Glu Leu Thr Leu 
                565                 570                 575     


Glu Arg Asp Pro Asp Val Leu Asp Thr Trp Phe Ser Ser Ala Leu Phe 
            580                 585                 590         


Pro Phe Ser Ala Leu Gly Trp Pro Gln Glu Thr Pro Asp Leu Ala Arg 
        595                 600                 605             


Phe Tyr Pro Leu Ser Leu Leu Glu Thr Gly Ser Asp Leu Leu Leu Phe 
    610                 615                 620                 


Trp Val Gly Arg Met Val Met Leu Gly Thr Gln Leu Thr Gly Gln Leu 
625                 630                 635                 640 


Pro Phe Ser Lys Val Leu Leu His Pro Met Val Arg Asp Arg Gln Gly 
                645                 650                 655     


Arg Lys Met Ser Lys Ser Leu Gly Asn Val Leu Asp Pro Arg Asp Ile 
            660                 665                 670         


Ile Ser Gly Val Glu Met Gln Val Leu Gln Glu Lys Leu Arg Ser Gly 
        675                 680                 685             


Asn Leu Asp Pro Ala Glu Leu Ala Ile Val Ala Ala Ala Gln Lys Lys 
    690                 695                 700                 


Asp Phe Pro His Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe 
705                 710                 715                 720 


Thr Leu Cys Ser His Gly Val Gln Ala Gly Asp Leu His Leu Ser Val 
                725                 730                 735     


Ser Glu Val Gln Ser Cys Arg His Phe Cys Asn Lys Ile Trp Asn Ala 
            740                 745                 750         


Leu Arg Phe Ile Leu Asn Ala Leu Gly Glu Lys Phe Val Pro Gln Pro 
        755                 760                 765             


Ala Glu Glu Leu Ser Pro Ser Ser Pro Met Asp Ala Trp Ile Leu Ser 
    770                 775                 780                 


Arg Leu Ala Leu Ala Ala Gln Glu Cys Glu Arg Gly Phe Leu Thr Arg 
785                 790                 795                 800 


Glu Leu Ser Leu Val Thr His Ala Leu His His Phe Trp Leu His Asn 
                805                 810                 815     


Leu Cys Asp Val Tyr Leu Glu Ala Val Lys Pro Val Leu Trp His Ser 
            820                 825                 830         


Pro Arg Pro Leu Gly Pro Pro Gln Val Leu Phe Ser Cys Ala Asp Leu 
        835                 840                 845             


Gly Leu Arg Leu Leu Ala Pro Leu Met Pro Phe Leu Ala Glu Glu Leu 
    850                 855                 860                 


Trp Gln Arg Leu Pro Pro Arg Pro Gly Cys Pro Pro Ala Pro Ser Ile 
865                 870                 875                 880 


Ser Val Ala Pro Tyr Pro Ser Ala Cys Ser Leu Glu His Trp Arg Gln 
                885                 890                 895     


Pro Glu Leu Glu Arg Arg Phe Ser Arg Val Gln Glu Val Val Gln Val 
            900                 905                 910         


Leu Arg Ala Leu Arg Ala Thr Tyr Gln Leu Thr Lys Ala Arg Pro Arg 
        915                 920                 925             


Val Leu Leu Gln Ser Ser Glu Pro Gly Asp Gln Gly Leu Phe Glu Ala 
    930                 935                 940                 


Phe Leu Glu Pro Leu Gly Thr Leu Gly Tyr Cys Gly Ala Val Gly Leu 
945                 950                 955                 960 


Leu Pro Pro Gly Ala Ala Ala Pro Ser Gly Trp Ala Gln Ala Pro Leu 
                965                 970                 975     


Ser Asp Thr Ala Gln Val Tyr Met Glu Leu Gln Gly Leu Val Asp Pro 
            980                 985                 990         


Gln Ile Gln Leu Pro Leu Leu Ala  Ala Arg Arg Tyr Lys  Leu Gln Lys 
        995                 1000                 1005             


Gln Leu  Asp Ser Leu Thr Ala  Arg Thr Pro Ser Glu  Gly Glu Ala 
    1010                 1015                 1020             


Gly Thr  Gln Arg Gln Gln Lys  Leu Ser Ser Leu Gln  Leu Glu Leu 
    1025                 1030                 1035             


Ser Lys  Leu Asp Lys Ala Ala  Ser His Leu Gln Gln  Leu Met Asp 
    1040                 1045                 1050             


Glu Pro  Pro Ala Pro Gly Ser  Pro Glu Leu 
    1055                 1060             


<210>  1464
<211>  422
<212>  DNA
<213>  Homosapiens

<400>  1464
aaggagaggc caccgggact tcagtgtctc ctccatccca ggagcgcagt ggccactatg     60

gggtctgggc tgccccttgt cctcctcttg accctccttg gcagctcaca tggaacaggg    120

ccgggtatga ctttgcaact gaagctgaag gagtcttttc tgacaaattc ctcctatgag    180

tccagcttcc tggaattgct tgaaaagctc tgcctcctcc tccatctccc ttcagggacc    240

agcgtcaccc tccaccatgc aagatctcaa caccatgttg tctgcaacac atgacagcca    300

ttgaagcctg tgtccttctt ggcccgggct tttgggccgg ggatgcagga ggcaggcccc    360

gaccctgtct ttcagcaggc ccccaccctc ctgagtggca ataaataaaa ttcggtatgc    420

tg                                                                   422


<210>  1465
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  1465

Met Gly Ser Gly Leu Pro Leu Val Leu Leu Leu Thr Leu Leu Gly Ser 
1               5                   10                  15      


Ser His Gly Thr Gly Pro Gly Met Thr Leu Gln Leu Lys Leu Lys Glu 
            20                  25                  30          


Ser Phe Leu Thr Asn Ser Ser Tyr Glu Ser Ser Phe Leu Glu Leu Leu 
        35                  40                  45              


Glu Lys Leu Cys Leu Leu Leu His Leu Pro Ser Gly Thr Ser Val Thr 
    50                  55                  60                  


Leu His His Ala Arg Ser Gln His His Val Val Cys Asn Thr 
65                  70                  75              


<210>  1466
<211>  1989
<212>  DNA
<213>  Homosapiens

<400>  1466
acatggagaa aggaccacat cacccaatga caagatcacc tcatctgcag cagagtctac     60

agaacataga gatagggcta catcagccaa tgtgatcaca ccagccccag cagagcctat    120

aaaacatgca aaaaggacca cattggccca tgagaagatg acacaagtca cagaaaagtc    180

cacagaacac ccagaaaaga ccacgtcaac cacagagaaa accacaagaa ccccagaaaa    240

gcctacgcta tactcagaga agaccatatg caccaaaggg aaaaacacac cagtcccaga    300

aaagcctaca gaaaacctgg ggaacaccac actgaccact gagaccataa aagccccagt    360

aaagtccaca gaaaacccag aaaaaacagc agcagtcaca aagactataa aaccttcagt    420

caaggtcaca ggagacaaat ctctcactac tacctcttct catctaaata aaactgaagt    480

tactcatcag gtgcccactg gttctttcac cctcattaca tctagaacga agctgagttc    540

tatcacatca gaagccacag gaaacgagag ccatccatac ctcaataaag atggctcaca    600

gaaaggtatc cacgctggac agatgggaga gaatgattca ttccctgcat gggccatagt    660

tattgtggtc ctggtggctg tgattctcct cctggtgttc cttggcctga tcttcttggt    720

ctcctatatg atgcggacac gccgcacact aacccagaac acccagtaca atgatgcaga    780

ggatgagggt ggccccaatt cctacccggt ctacctgatg gagcagcaga atcttggcat    840

gggccagatc ccttccccac ggtgatcttg gagtaggcgc ccagccctgg ctcttccatg    900

ctctgcccct ttcctggatg aggaaccgga ctcacaattt ctatttccgg gactacagga    960

agggcagaga atactgacgg ttaccagtat taacccttca tctgttcttg aaactggttg   1020

gggaatgagg tgataagcaa ggagggtgta agtttagggg acaaagaaga aagaatgaat   1080

aatacgagca gacattctct gtagaaggta atggtctgag aatgaaaagg tgtttgatgg   1140

acatgttgtg ggggcaccaa tgcagaacac tgcactgagt cctaaaggaa ggacaggagc   1200

cttataggca atgccccaga ctgacttgtg agtggggttt atggggaaag ggagggactg   1260

agggcagagt ctctgggttt caggacagca ttatgttatt tccattcact attacttaag   1320

agtttgtgtg taaacaggct catctctgag ttctcaggac ccttgccccc acccccattt   1380

ttttaatgaa aaaaaaaaac aaaaaaaacg gatccaagaa gaaaagagaa tttatttcct   1440

tctccactct ctccatgccc tggagaaaaa aaagtccaga agaaatcata aatatctctc   1500

atctacatgg ttgcttcctc ttcctcccaa atcccttagt tttcctaaat gtctacagtg   1560

gacgccctgt tggtttggct tgctgggttg tgggtggaca cgcaaggagg ggatttttat   1620

ttggccagca gtctcaccca ctgatctcca ccccagacct tccctgattg gtgtctcagc   1680

atttattttc ctgtctcttc caccaaaagc cagctgtagc tttatctcgt aaaagttacc   1740

catcttctct actgtcccca ttctctctcc tcccaccttc accccagatt caagttttcc   1800

tccttgtagg catttcatct gtgtgtgttt tctggatttt ctctctctct tcttatggcc   1860

atttcacctt attactgatt gggtagaggg ggaaaaggag aatgatgatg atagtttcct   1920

tctgtctatt gacctttttt ataataaagt ataacatgtt tataaaggga aaaaaaaaaa   1980

aaaaaaaaa                                                           1989


<210>  1467
<211>  235
<212>  PRT
<213>  Homosapiens

<400>  1467

Met Thr Gln Val Thr Glu Lys Ser Thr Glu His Pro Glu Lys Thr Thr 
1               5                   10                  15      


Ser Thr Thr Glu Lys Thr Thr Arg Thr Pro Glu Lys Pro Thr Leu Tyr 
            20                  25                  30          


Ser Glu Lys Thr Ile Cys Thr Lys Gly Lys Asn Thr Pro Val Pro Glu 
        35                  40                  45              


Lys Pro Thr Glu Asn Leu Gly Asn Thr Thr Leu Thr Thr Glu Thr Ile 
    50                  55                  60                  


Lys Ala Pro Val Lys Ser Thr Glu Asn Pro Glu Lys Thr Ala Ala Val 
65                  70                  75                  80  


Thr Lys Thr Ile Lys Pro Ser Val Lys Val Thr Gly Asp Lys Ser Leu 
                85                  90                  95      


Thr Thr Thr Ser Ser His Leu Asn Lys Thr Glu Val Thr His Gln Val 
            100                 105                 110         


Pro Thr Gly Ser Phe Thr Leu Ile Thr Ser Arg Thr Lys Leu Ser Ser 
        115                 120                 125             


Ile Thr Ser Glu Ala Thr Gly Asn Glu Ser His Pro Tyr Leu Asn Lys 
    130                 135                 140                 


Asp Gly Ser Gln Lys Gly Ile His Ala Gly Gln Met Gly Glu Asn Asp 
145                 150                 155                 160 


Ser Phe Pro Ala Trp Ala Ile Val Ile Val Val Leu Val Ala Val Ile 
                165                 170                 175     


Leu Leu Leu Val Phe Leu Gly Leu Ile Phe Leu Val Ser Tyr Met Met 
            180                 185                 190         


Arg Thr Arg Arg Thr Leu Thr Gln Asn Thr Gln Tyr Asn Asp Ala Glu 
        195                 200                 205             


Asp Glu Gly Gly Pro Asn Ser Tyr Pro Val Tyr Leu Met Glu Gln Gln 
    210                 215                 220                 


Asn Leu Gly Met Gly Gln Ile Pro Ser Pro Arg 
225                 230                 235 


<210>  1468
<211>  3646
<212>  DNA
<213>  Homosapiens

<400>  1468
agagaaagag gcaactacat tgcctggagg aagcctaagg aacccaggca tccagctgcc     60

cacgcccgag tccaagattc ttcccaggaa cacaaacgta ggagacccac gctcctggaa    120

gcaccagcct ttatctcttc accttcaagt cccctttctc aagaatcctc tgttctttgc    180

cctctaaagt cttggtacat ctaggaccca ggcatcttgc tttccagcca caaagagaca    240

gatgaagatg cagaaaggaa atgttctcct tatgtttggt ctactattgc atttagaagc    300

tgcaacaaat tccaatgaga ctagcacctc tgccaacact ggatccagtg tgatctccag    360

tggagccagc acagccacca actctgggtc cagtgtgacc tccagtgggg tcagcacagc    420

caccatctca gggtccagcg tgacctccaa tggggtcagc atagtcacca actctgagtt    480

ccatacaacc tccagtggga tcagcacagc caccaactct gagttcagca cagcgtccag    540

tgggatcagc atagccacca actctgagtc cagcacaacc tccagtgggg ccagcacagc    600

caccaactct gagtccagca caccctccag tggggccagc acagccacca actctgactc    660

cagcacaacc tccagtgggg ctagcacagc caccaactct gactccagca caacctccag    720

tgaggccagc acagccacca actctgagtc cagcacaacc tccagtgggg ccagcacagc    780

caccaactct gagtccagca cagtgtccag tagggccagc actgccacca actctgagtc    840

cagcacaacc tccagtgggg ccagcacagc caccaactct gagtccagaa cgacctccaa    900

tggggctggc acagccacca actctgagtc cagcacgacc tccagtgggg ccagcacagc    960

caccaactct gagtccagca caccctccag tggggccggc acagccacca actctgagtc   1020

cagcacgacc tccagtgggg ccggcacagc caccaactct gagtccagca cagtgtccag   1080

tgggatcagc acagtcacca attctgagtc cagcacaccc tccagtgggg ccaacacagc   1140

caccaactct gagtccagta caacctccag tggggccaac acagccacca actctgactc   1200

cagcacaacc tccagtgggg ccagcacagc caccaactct gagtccagca cgacctccag   1260

tggggccagc acagccacca actctgagtc cagcacaacc tccagtgggg ccagcacagc   1320

caccaactct gggtccagca cgacctccag tgggaccagc acagccacca actctgagtc   1380

cagcacagtg tccagtgggg ccagcacagc caccacctct gagtccagca cgacctccag   1440

tggggccagc acagccacca actctgagtc cagcacagtg tccagtgggg ccagcactgc   1500

caccaattct gagtccagca caacctccag tggggccaac acagccacca actctgggtc   1560

cagtgtgacc tctgcaggct ctggaacagc agctctgact ggaatgcaca caacttccca   1620

tagtgcatct actgcagtga gtgaggcgaa gcctggtggg tccctggtgc cgtgggaaat   1680

cttcctcatc accctggtct cggttgtggc ggccgtgggg ctctttgctg ggctcttctt   1740

ctgtgtgaga aacagcctgt ccctgagaaa cacctttaac acagctgtct accaccctca   1800

tggcctcaac catggccttg gtccaggccc tggagggaat catggagccc cccacaggcc   1860

caggtggagt cctaactggt tctggaggag accagtatcc tcgatagcca tggagatgag   1920

cgggaggaac agcgggccct gagcagcccc ggaagcaagt gccgcattct tcaggaagga   1980

agagacctgg gcacccaaga cctggtttcc tttcattcat cccaggagac ccctcccagc   2040

tttgtttgag atcctgaaaa tcttgaagaa ggtattcctc acctttcttg cctttaccag   2100

acactggaaa gagaatacta tattgctcat ttagctaaga aataaataca tctcatctaa   2160

cacacacgac aaagagaagc tgtgcgtgcc ccggggtggg tatctagctc tgagatgaac   2220

tcagttatag gagaaaacct ccatgctgga ctccatctgg cattcaaaat ctccacagta   2280

aaatccaaag acctcattct tatctgtgtg tctgcatttt ctaatccttt ttgccccagg   2340

caaggtccct gtatctctga gacaccccga ttggctggag aattgacttg ggagagataa   2400

ggagggaggg cgggtgccag catgctatgg gctcctgcgt gaggcctgtg gtacacagag   2460

attaggttgt gatacatgaa gagccaagag caggatgagg tggaggcgtt acaactacct   2520

gctctgtgtg tgggggggga ggggggaggg gggtacgcat attcacttga agtcgaggtt   2580

cccagggcat ttccatgtgc tccaggcctg actacccatc agggtggagg agctggtgac   2640

actcatctcc ctgagtgctc cctggtttcc caagggaaag actttctggc ctgctgaggt   2700

cgaatcttcc aagaggctct tgcaaagacc cgagattctc ataaatcccc gcccagaaga   2760

gctgcacgta tccctttcat gagtccaggg aagagggtcc tccaggtctt ggaagacaga   2820

ggggagctgc tttagaggct aagttgcttt gagcccacaa ggtaatggag ggctcctact   2880

tgggacagag ccctcagcag agaattagca gtctgttggt gggttcaccc caactcacag   2940

cagtagaaac tgctccatct tccaccactt attgggtttc tccagtgtca gcaaaccaaa   3000

gaattggatc ttaccaatgc ggctatagga aaacagcctg ttgcatggta agagtgatac   3060

catcttgaag tgaaaccacc acaatggcca tttttttttt agatggagtt ttgcagtggt   3120

gcaatcatag ctcattgcag ccttcaattc ctgggctcag gcaatcctcc tgcctcagcc   3180

tcctgagtag ctgggactac agtttcgtgt gccaccatgc ctggctaatt tttagaattt   3240

tttgtaggga cagggcctca ctctgttgca caagctggtc ttgaactcct ggcctccttg   3300

aactcctcct gccttggcct cccaaaatgc tgagattaca ggtgtgagcc actgcacctc   3360

gccagatgtc caatgtctga ctcctgcata ccaaggtgtt ctgtatcaag ggctttaaaa   3420

caatgcctgt agcgtaatta acctctcaca aagatgctta tctaacctcc ccagcagtca   3480

tgggtttcag caagaaagtc tgtgatgtga ccagttgcac atgttttccc ctaaaagctt   3540

actctagaaa ggatattttt tggagaggga gtgtgggaat ccaccatcct gtggccacct   3600

cagacatcac ttctctttgg aagactccat taaatatttc tctgtg                  3646


<210>  1469
<211>  566
<212>  PRT
<213>  Homosapiens

<400>  1469

Met Lys Met Gln Lys Gly Asn Val Leu Leu Met Phe Gly Leu Leu Leu 
1               5                   10                  15      


His Leu Glu Ala Ala Thr Asn Ser Asn Glu Thr Ser Thr Ser Ala Asn 
            20                  25                  30          


Thr Gly Ser Ser Val Ile Ser Ser Gly Ala Ser Thr Ala Thr Asn Ser 
        35                  40                  45              


Gly Ser Ser Val Thr Ser Ser Gly Val Ser Thr Ala Thr Ile Ser Gly 
    50                  55                  60                  


Ser Ser Val Thr Ser Asn Gly Val Ser Ile Val Thr Asn Ser Glu Phe 
65                  70                  75                  80  


His Thr Thr Ser Ser Gly Ile Ser Thr Ala Thr Asn Ser Glu Phe Ser 
                85                  90                  95      


Thr Ala Ser Ser Gly Ile Ser Ile Ala Thr Asn Ser Glu Ser Ser Thr 
            100                 105                 110         


Thr Ser Ser Gly Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Pro 
        115                 120                 125             


Ser Ser Gly Ala Ser Thr Ala Thr Asn Ser Asp Ser Ser Thr Thr Ser 
    130                 135                 140                 


Ser Gly Ala Ser Thr Ala Thr Asn Ser Asp Ser Ser Thr Thr Ser Ser 
145                 150                 155                 160 


Glu Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Thr Ser Ser Gly 
                165                 170                 175     


Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Val Ser Ser Arg Ala 
            180                 185                 190         


Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Thr Ser Ser Gly Ala Ser 
        195                 200                 205             


Thr Ala Thr Asn Ser Glu Ser Arg Thr Thr Ser Asn Gly Ala Gly Thr 
    210                 215                 220                 


Ala Thr Asn Ser Glu Ser Ser Thr Thr Ser Ser Gly Ala Ser Thr Ala 
225                 230                 235                 240 


Thr Asn Ser Glu Ser Ser Thr Pro Ser Ser Gly Ala Gly Thr Ala Thr 
                245                 250                 255     


Asn Ser Glu Ser Ser Thr Thr Ser Ser Gly Ala Gly Thr Ala Thr Asn 
            260                 265                 270         


Ser Glu Ser Ser Thr Val Ser Ser Gly Ile Ser Thr Val Thr Asn Ser 
        275                 280                 285             


Glu Ser Ser Thr Pro Ser Ser Gly Ala Asn Thr Ala Thr Asn Ser Glu 
    290                 295                 300                 


Ser Ser Thr Thr Ser Ser Gly Ala Asn Thr Ala Thr Asn Ser Asp Ser 
305                 310                 315                 320 


Ser Thr Thr Ser Ser Gly Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser 
                325                 330                 335     


Thr Thr Ser Ser Gly Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr 
            340                 345                 350         


Thr Ser Ser Gly Ala Ser Thr Ala Thr Asn Ser Gly Ser Ser Thr Thr 
        355                 360                 365             


Ser Ser Gly Thr Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Val Ser 
    370                 375                 380                 


Ser Gly Ala Ser Thr Ala Thr Thr Ser Glu Ser Ser Thr Thr Ser Ser 
385                 390                 395                 400 


Gly Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Val Ser Ser Gly 
                405                 410                 415     


Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Thr Ser Ser Gly Ala 
            420                 425                 430         


Asn Thr Ala Thr Asn Ser Gly Ser Ser Val Thr Ser Ala Gly Ser Gly 
        435                 440                 445             


Thr Ala Ala Leu Thr Gly Met His Thr Thr Ser His Ser Ala Ser Thr 
    450                 455                 460                 


Ala Val Ser Glu Ala Lys Pro Gly Gly Ser Leu Val Pro Trp Glu Ile 
465                 470                 475                 480 


Phe Leu Ile Thr Leu Val Ser Val Val Ala Ala Val Gly Leu Phe Ala 
                485                 490                 495     


Gly Leu Phe Phe Cys Val Arg Asn Ser Leu Ser Leu Arg Asn Thr Phe 
            500                 505                 510         


Asn Thr Ala Val Tyr His Pro His Gly Leu Asn His Gly Leu Gly Pro 
        515                 520                 525             


Gly Pro Gly Gly Asn His Gly Ala Pro His Arg Pro Arg Trp Ser Pro 
    530                 535                 540                 


Asn Trp Phe Trp Arg Arg Pro Val Ser Ser Ile Ala Met Glu Met Ser 
545                 550                 555                 560 


Gly Arg Asn Ser Gly Pro 
                565     


<210>  1470
<211>  1145
<212>  DNA
<213>  Homosapiens

<400>  1470
atgcagggcc gcgtggcagg gagctgcgct cctctgggcc tgctcctggt ctgtcttcat     60

ctcccaggcc tctttgcccg gagcatcggt gttgtggagg agaaagtttc ccaaaacttg    120

gggaccaact tgcctcagct cggacaacct tcctccactg gcccctctaa ctctgaacat    180

ccgcagcccg ctctggaccc taggtctaat gacttggcaa gggttcctct gaagctcagc    240

gtgcctgcat cagatggctt cccacctgca ggaggttctg cagtgcagag gtggcctcca    300

tcgtgggggc tgcctgccat ggattcctgg ccccctgagg atccttggca gatgatggct    360

gctgcggctg aggaccgcct gggggaagcg ctgcctgaag aactctctta cctctccagt    420

gctgcggccc tcgctccggg cagtggccct ttgcctgggg agtcttctcc cgatgccaca    480

ggcctctcac ccgaggcttc actcctccac caggactcgg agtccagacg actgccccgt    540

tctaattcac tgggagccgg gggaaaaatc ctttcccaac gccctccctg gtctctcatc    600

cacagggttc tgcctgatca cccctggggt accctgaatc ccagtgtgtc ctggggaggt    660

ggaggccctg ggactggttg gggaacgagg cccatgccac accctgaggg aatctggggt    720

atcaataatc aacccccagg taccagctgg ggaaatatta atcggtatcc aggaggcagc    780

tggggaaata ttaatcggta tccaggaggc agctggggga atattaatcg gtatccagga    840

ggcagctggg ggaatattca tctataccca ggtatcaata acccatttcc tcctggagtt    900

ctccgccctc ctggctcttc ttggaacatc ccagctggct tccctaatcc tccaagccct    960

aggttgcagt ggggctagag cacgatagag ggaaacccaa cattgggagt tagagtcctg   1020

ctcccgcccc ttgctgtgtg ggctcaatcc aggccctgtt aacatgtttc cagcactatc   1080

cccacttttc agtgcctccc ctgctcatct ccaataaaat aaaagcactt atggaaaaaa   1140

aaaaa                                                               1145


<210>  1471
<211>  325
<212>  PRT
<213>  Homosapiens

<400>  1471

Met Gln Gly Arg Val Ala Gly Ser Cys Ala Pro Leu Gly Leu Leu Leu 
1               5                   10                  15      


Val Cys Leu His Leu Pro Gly Leu Phe Ala Arg Ser Ile Gly Val Val 
            20                  25                  30          


Glu Glu Lys Val Ser Gln Asn Leu Gly Thr Asn Leu Pro Gln Leu Gly 
        35                  40                  45              


Gln Pro Ser Ser Thr Gly Pro Ser Asn Ser Glu His Pro Gln Pro Ala 
    50                  55                  60                  


Leu Asp Pro Arg Ser Asn Asp Leu Ala Arg Val Pro Leu Lys Leu Ser 
65                  70                  75                  80  


Val Pro Ala Ser Asp Gly Phe Pro Pro Ala Gly Gly Ser Ala Val Gln 
                85                  90                  95      


Arg Trp Pro Pro Ser Trp Gly Leu Pro Ala Met Asp Ser Trp Pro Pro 
            100                 105                 110         


Glu Asp Pro Trp Gln Met Met Ala Ala Ala Ala Glu Asp Arg Leu Gly 
        115                 120                 125             


Glu Ala Leu Pro Glu Glu Leu Ser Tyr Leu Ser Ser Ala Ala Ala Leu 
    130                 135                 140                 


Ala Pro Gly Ser Gly Pro Leu Pro Gly Glu Ser Ser Pro Asp Ala Thr 
145                 150                 155                 160 


Gly Leu Ser Pro Glu Ala Ser Leu Leu His Gln Asp Ser Glu Ser Arg 
                165                 170                 175     


Arg Leu Pro Arg Ser Asn Ser Leu Gly Ala Gly Gly Lys Ile Leu Ser 
            180                 185                 190         


Gln Arg Pro Pro Trp Ser Leu Ile His Arg Val Leu Pro Asp His Pro 
        195                 200                 205             


Trp Gly Thr Leu Asn Pro Ser Val Ser Trp Gly Gly Gly Gly Pro Gly 
    210                 215                 220                 


Thr Gly Trp Gly Thr Arg Pro Met Pro His Pro Glu Gly Ile Trp Gly 
225                 230                 235                 240 


Ile Asn Asn Gln Pro Pro Gly Thr Ser Trp Gly Asn Ile Asn Arg Tyr 
                245                 250                 255     


Pro Gly Gly Ser Trp Gly Asn Ile Asn Arg Tyr Pro Gly Gly Ser Trp 
            260                 265                 270         


Gly Asn Ile Asn Arg Tyr Pro Gly Gly Ser Trp Gly Asn Ile His Leu 
        275                 280                 285             


Tyr Pro Gly Ile Asn Asn Pro Phe Pro Pro Gly Val Leu Arg Pro Pro 
    290                 295                 300                 


Gly Ser Ser Trp Asn Ile Pro Ala Gly Phe Pro Asn Pro Pro Ser Pro 
305                 310                 315                 320 


Arg Leu Gln Trp Gly 
                325 


<210>  1472
<211>  861
<212>  DNA
<213>  Homosapiens

<400>  1472
caggaaatcg agactcatga ctcccagaga ggatggcatc tagaagtaga cgatcaaggg     60

tggaatctac agtccatggg ccctgacttc ttgccttcgt ctcaaataga ctctgcagcc    120

agccatctat gcagcgcccc agtggctttg aaatgcaaca gaaaccatca cccccggacc    180

gtgggctcca tgccagtggg caaagcacag cctgggaaga attggtttgc agccaggcag    240

tcctccatcc agtcttgact ttggcacttg tgatatgact tgcacagacc aaaaaagtca    300

ctctcaaaga gctctcggca cacagacccc agctttacaa ggaccccagc tccttaacac    360

agatcccagc tccaaggaaa ctcgtccccc ccacgttaat cctgaccgac tttgccacat    420

ggagccagca aaccatttct ggcatgcagg ggacctccaa gcaatgatat ccaaggaatt    480

ccatctggca gccacccagg atgactgcag aaaaggaagg acacaggagg atatcctggt    540

tccctcttcc cacccagagc tgtttgcatc agtcctgcca atggctccgg aagaagctgc    600

caggctccag caacctcagc cccttcctcc tccctcagga atccacctat ccgcctctag    660

gaccttggct ccaactctat tgtactcgtc tcctccctcc cattctcctt ttggtctcag    720

ctccttgatc taagcctccc agagagaccc ctagaatgtt tccctcaagg acctttctgc    780

ctggaagtct gttagccttt cagaagtaac atgtccaaaa taaaatttga ttcctcccag    840

gttgttccct gcctggtccg c                                              861


<210>  1473
<211>  152
<212>  PRT
<213>  Homosapiens

<400>  1473

Met Thr Cys Thr Asp Gln Lys Ser His Ser Gln Arg Ala Leu Gly Thr 
1               5                   10                  15      


Gln Thr Pro Ala Leu Gln Gly Pro Gln Leu Leu Asn Thr Asp Pro Ser 
            20                  25                  30          


Ser Lys Glu Thr Arg Pro Pro His Val Asn Pro Asp Arg Leu Cys His 
        35                  40                  45              


Met Glu Pro Ala Asn His Phe Trp His Ala Gly Asp Leu Gln Ala Met 
    50                  55                  60                  


Ile Ser Lys Glu Phe His Leu Ala Ala Thr Gln Asp Asp Cys Arg Lys 
65                  70                  75                  80  


Gly Arg Thr Gln Glu Asp Ile Leu Val Pro Ser Ser His Pro Glu Leu 
                85                  90                  95      


Phe Ala Ser Val Leu Pro Met Ala Pro Glu Glu Ala Ala Arg Leu Gln 
            100                 105                 110         


Gln Pro Gln Pro Leu Pro Pro Pro Ser Gly Ile His Leu Ser Ala Ser 
        115                 120                 125             


Arg Thr Leu Ala Pro Thr Leu Leu Tyr Ser Ser Pro Pro Ser His Ser 
    130                 135                 140                 


Pro Phe Gly Leu Ser Ser Leu Ile 
145                 150         


<210>  1474
<211>  2549
<212>  DNA
<213>  Homosapiens

<400>  1474
atcagtcagg aggccgtgca gtccgagatg ggctcgtctc gggcaccctg gatggggcgt     60

gtgggtgggc acgggatgat ggcactgctg ctggctggtc tcctcctgcc agggaccttg    120

gctaagagca ttggcacctt ctcagacccc tgtaaggacc ccacgcgtat cacctcccct    180

aacgacccct gcctcactgg gaagggtgac tccagcggct tcagtagcta cagtggctcc    240

agcagttctg gcagctccat ttccagtgcc agaagctctg gtggtggctc cagtggtagc    300

tccagcggat ccagcattgc ccagggtggt tctgcaggat cttttaagcc aggaacgggg    360

tattcccagg tcagctactc ctccggatct ggctctagtc tacaaggtgc atccggttcc    420

tcccagctgg ggagcagcag ctctcactcg ggaagcagcg gctctcactc gggaagcagc    480

agctctcatt cgagcagcag cagcagcttt cagttcagca gcagcagctt ccaagtaggg    540

aatggctctg ctctgccaac caatgacaac tcttaccgcg gaatactaaa cccttcccag    600

cctggacaaa gctcttcctc ttcccagacc tttggggtat ccagcagtgg ccaaagcgtc    660

agctccaacc agcgtccctg tagttcggac atccccgact ctccctgcag tggagggccc    720

atcgtctcgc actccggccc ctacatcccc agctcccact ctgtgtcagg gggtcagagg    780

cctgtggtgg tggtggtgga ccagcacggt tctggtgccc ctggagtggt tcaaggtccc    840

ccctgtagca atggtggcct tccaggcaag ccctgtcccc caatcacctc tgtagacaaa    900

tcctatggtg gctacgaggt ggtgggtggc tcctctgaca gttatctggt tccaggcatg    960

acctacagta agggtaaaat ctaccctgtg ggctacttca ccaaagagaa ccctgtgaaa   1020

ggctctccag gggtcccttc ctttgcagct gggcccccca tctctgaggg caaatacttc   1080

tccagcaacc ccatcatccc cagccagtcg gcagcttcct cggccattgc attccagcca   1140

gtggggactg gtggggtcca gctctgtgga ggcggctcca cgggctccaa gggaccctgc   1200

tctccctcca gttctcgagt ccccagcagt tctagcattt ccagcagctc cggtttaccc   1260

taccatccct gcggcagtgc ttcccagagc ccctgctccc caccaggcac cggctccttc   1320

agcagcagct ccagttccca atccagtggc aaaatcatcc ttcagccttg tggcagcaag   1380

tccagctctt ctggtcaccc ttgcatgtct gtctcctcct tgacactgac tgggggcccc   1440

gatggctctc cccatcctga tccctccgct ggtgccaagc cctgtggctc cagcagtgct   1500

ggaaagatcc cctgccgctc catccgggat atcctagccc aagtgaagcc tctggggccc   1560

cagctagctg accctgaagt tttcctaccc caaggagagt tactcaacag tccataagaa   1620

gtcaactgtt gtgtgtgtgc atgccttggg cacaaacaag cacatacact atatcccata   1680

tgggagaagt ccagtgccca ggcatagggt tagctcagtt tccctccttc ccaaaagagt   1740

ggttctgctt tctccactac cccaaggttg cagactctct cttatcaccc cttcctcctt   1800

cctcttctca aaatggtaga ttcaaagctc ctctcttgat tctctcctac tgtttaaatt   1860

cccattccac cacagtgccc ctcagccaga tcaccacccc ttacaattcc ctctactgtg   1920

tggaaatggt ccattgagta acacccccat cagcttctca actgggaaac ccctgaaatg   1980

ctctcagagc acctctgacg cctgaagaag ttataccttc ctcttcccct ttaccaaata   2040

aagcaaagtc aaaccatcat ctggaaacag tggccacttt tcactgacct ttcttcgaca   2100

tctagtcaac ccacccaata tgccactggg ctctcgctcc caattccacc ccaccctcca   2160

ttacagagct caccacgccc tcctagatca ccgtccccaa cacacccatt gcctctcaag   2220

gcccttatct cagccccttc ctgtggccac ttccctcagt gctcagatga ttccctgggt   2280

gagggagaca ctggggcacc ctcagaggtt gaagcaggct ccctgctgtc cctggatcct   2340

ggacagatgg ctcagtaaac tgtggggact aggtgcagac tttttgcctt cttggagtcc   2400

tgggtctcct ctgagagtct gggtggtgct cttcctacgc ctctagaggt ctctgtgttc   2460

ctcattttcc ttcaaaagcg ggctgtgttt ctcttctacc ttccagctgc tcccacagag   2520

gaggaagaca ataaatattt gttgaactg                                     2549


<210>  1475
<211>  529
<212>  PRT
<213>  Homosapiens

<400>  1475

Met Gly Ser Ser Arg Ala Pro Trp Met Gly Arg Val Gly Gly His Gly 
1               5                   10                  15      


Met Met Ala Leu Leu Leu Ala Gly Leu Leu Leu Pro Gly Thr Leu Ala 
            20                  25                  30          


Lys Ser Ile Gly Thr Phe Ser Asp Pro Cys Lys Asp Pro Thr Arg Ile 
        35                  40                  45              


Thr Ser Pro Asn Asp Pro Cys Leu Thr Gly Lys Gly Asp Ser Ser Gly 
    50                  55                  60                  


Phe Ser Ser Tyr Ser Gly Ser Ser Ser Ser Gly Ser Ser Ile Ser Ser 
65                  70                  75                  80  


Ala Arg Ser Ser Gly Gly Gly Ser Ser Gly Ser Ser Ser Gly Ser Ser 
                85                  90                  95      


Ile Ala Gln Gly Gly Ser Ala Gly Ser Phe Lys Pro Gly Thr Gly Tyr 
            100                 105                 110         


Ser Gln Val Ser Tyr Ser Ser Gly Ser Gly Ser Ser Leu Gln Gly Ala 
        115                 120                 125             


Ser Gly Ser Ser Gln Leu Gly Ser Ser Ser Ser His Ser Gly Ser Ser 
    130                 135                 140                 


Gly Ser His Ser Gly Ser Ser Ser Ser His Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Phe Gln Phe Ser Ser Ser Ser Phe Gln Val Gly Asn Gly Ser Ala Leu 
                165                 170                 175     


Pro Thr Asn Asp Asn Ser Tyr Arg Gly Ile Leu Asn Pro Ser Gln Pro 
            180                 185                 190         


Gly Gln Ser Ser Ser Ser Ser Gln Thr Phe Gly Val Ser Ser Ser Gly 
        195                 200                 205             


Gln Ser Val Ser Ser Asn Gln Arg Pro Cys Ser Ser Asp Ile Pro Asp 
    210                 215                 220                 


Ser Pro Cys Ser Gly Gly Pro Ile Val Ser His Ser Gly Pro Tyr Ile 
225                 230                 235                 240 


Pro Ser Ser His Ser Val Ser Gly Gly Gln Arg Pro Val Val Val Val 
                245                 250                 255     


Val Asp Gln His Gly Ser Gly Ala Pro Gly Val Val Gln Gly Pro Pro 
            260                 265                 270         


Cys Ser Asn Gly Gly Leu Pro Gly Lys Pro Cys Pro Pro Ile Thr Ser 
        275                 280                 285             


Val Asp Lys Ser Tyr Gly Gly Tyr Glu Val Val Gly Gly Ser Ser Asp 
    290                 295                 300                 


Ser Tyr Leu Val Pro Gly Met Thr Tyr Ser Lys Gly Lys Ile Tyr Pro 
305                 310                 315                 320 


Val Gly Tyr Phe Thr Lys Glu Asn Pro Val Lys Gly Ser Pro Gly Val 
                325                 330                 335     


Pro Ser Phe Ala Ala Gly Pro Pro Ile Ser Glu Gly Lys Tyr Phe Ser 
            340                 345                 350         


Ser Asn Pro Ile Ile Pro Ser Gln Ser Ala Ala Ser Ser Ala Ile Ala 
        355                 360                 365             


Phe Gln Pro Val Gly Thr Gly Gly Val Gln Leu Cys Gly Gly Gly Ser 
    370                 375                 380                 


Thr Gly Ser Lys Gly Pro Cys Ser Pro Ser Ser Ser Arg Val Pro Ser 
385                 390                 395                 400 


Ser Ser Ser Ile Ser Ser Ser Ser Gly Leu Pro Tyr His Pro Cys Gly 
                405                 410                 415     


Ser Ala Ser Gln Ser Pro Cys Ser Pro Pro Gly Thr Gly Ser Phe Ser 
            420                 425                 430         


Ser Ser Ser Ser Ser Gln Ser Ser Gly Lys Ile Ile Leu Gln Pro Cys 
        435                 440                 445             


Gly Ser Lys Ser Ser Ser Ser Gly His Pro Cys Met Ser Val Ser Ser 
    450                 455                 460                 


Leu Thr Leu Thr Gly Gly Pro Asp Gly Ser Pro His Pro Asp Pro Ser 
465                 470                 475                 480 


Ala Gly Ala Lys Pro Cys Gly Ser Ser Ser Ala Gly Lys Ile Pro Cys 
                485                 490                 495     


Arg Ser Ile Arg Asp Ile Leu Ala Gln Val Lys Pro Leu Gly Pro Gln 
            500                 505                 510         


Leu Ala Asp Pro Glu Val Phe Leu Pro Gln Gly Glu Leu Leu Asn Ser 
        515                 520                 525             


Pro 
    


<210>  1476
<211>  1143
<212>  DNA
<213>  Homosapiens

<400>  1476
gagatgccaa gtgggtattg actgctccag gatgtggatg gagggtgtga aaaccagggt     60

ggggtgacgc aggctctggg tcatgatagg gagagcaggc agctgggtcc tgggctggag    120

gactaaaata agggacgcca ccttcagggg tgacacatca gcccaggccc tccctacggg    180

tttgaccagt cctgttctga cggtattcct gcgccactgg gctggtccct cctccactcc    240

tcccctataa agcctcctgg ggtccccagg cacccagact cagcccaccc cagctttggg    300

ggccagtacg cagccatgat cctcaactgg aagctcctgg ggatcctggt cctttgcctg    360

cacaccagag gcatctcagg cagcgagggc cacccctctc acccacccgc agaggaccga    420

gaggaggcag gctccccaac attgcctcag ggccccccag tccccggtga cccttggcca    480

ggggcacccc ctctctttga agatcctccg cctacccgcc ccagtcgtcc ctggagagac    540

ctgcctgaaa ctggagtctg gccccctgaa ccgcctagaa cggatcctcc tcaacctccc    600

cggcctgacg acccttggcc ggcaggaccc cagcccccag aaaacccctg gcctcctgcc    660

cctgaggtgg acaaccgacc tcaggaggag ccagacctag acccaccccg ggaagagtac    720

agataatgga gtcccctcag ccgttctgtt cccaggcatc tccaggcacc cacgccctct    780

ccaccctctg attccccgtg aattcttccc aatttagcct atctccttaa acctcttcct    840

cattccctcg gttttattct gaacccgtaa ggtggtgttc tcaatatttc ctgtcccctc    900

ctgagatcca tacttagtcc tcacatcgcc cgttttttcc tctgacagcc taagcctact    960

ctcctacctc gcctccaggc ctcggcccca cctacctccc acccggtctt cctgcccgcg   1020

cgatcgctgg ggcagggcta cggtactgtg ttcccttctg ccacctggtg gccggcggca   1080

ggaactatca gtagacagct gctgcttcca tgaaacggaa aaataaaaat catgttttct   1140

taa                                                                 1143


<210>  1477
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  1477

Met Ile Leu Asn Trp Lys Leu Leu Gly Ile Leu Val Leu Cys Leu His 
1               5                   10                  15      


Thr Arg Gly Ile Ser Gly Ser Glu Gly His Pro Ser His Pro Pro Ala 
            20                  25                  30          


Glu Asp Arg Glu Glu Ala Gly Ser Pro Thr Leu Pro Gln Gly Pro Pro 
        35                  40                  45              


Val Pro Gly Asp Pro Trp Pro Gly Ala Pro Pro Leu Phe Glu Asp Pro 
    50                  55                  60                  


Pro Pro Thr Arg Pro Ser Arg Pro Trp Arg Asp Leu Pro Glu Thr Gly 
65                  70                  75                  80  


Val Trp Pro Pro Glu Pro Pro Arg Thr Asp Pro Pro Gln Pro Pro Arg 
                85                  90                  95      


Pro Asp Asp Pro Trp Pro Ala Gly Pro Gln Pro Pro Glu Asn Pro Trp 
            100                 105                 110         


Pro Pro Ala Pro Glu Val Asp Asn Arg Pro Gln Glu Glu Pro Asp Leu 
        115                 120                 125             


Asp Pro Pro Arg Glu Glu Tyr Arg 
    130                 135     


<210>  1478
<211>  2972
<212>  DNA
<213>  Homosapiens

<400>  1478
aaagaggagg cgggcagcag gcatggaagc taaggggata gtagagagaa gctgagagaa     60

cagccgcagg aaagatttga ataagatgtc aggacgctgg cttttctgcc tggggatcta    120

ggcggcctgg attcccaagg tcttggggag ggtctagccc tgcatgtggc cacattcagc    180

tggggccagg ccttgggcca gcactttaac agggaaggac ccaagagtca tggcctgctg    240

gtgtctggat gggcttccct caggccttgc tgagccatgg agagaactct ggagatggcg    300

ctcaagaccc ctgcactgtg tacctccttt ctcacctctg gccaggagca gcagggacca    360

tagaaactta aggaggaggg ggaacataga tggctgaaga cagaatctag agccttcaaa    420

taatgtggag atgtttccac cttcaggttc cactgggctg attcccccct cccactttca    480

agctcggccc ctttcaactc tgccaagaat ggctcccacc tggctctcag acattcccct    540

ggtccaaccc ccaggctatc aagatgtctc agagaggcgg ctagacaccc agagacctca    600

agtgaccatg tgggaacggg atgtttccag tgacaggcag gagccagggc ggagaggcag    660

gtcctggggg ctggaggggt cacaggccct gagccagcag gctgaggtga tcgttcggca    720

gctgcaagag ctgcggcggc tggaggagga ggtccggctc ctgcgggaga cctcgctgca    780

gcagaagatg aggctagagg cccaggccat ggagctagag gctctggcac gggcggagaa    840

ggccggccga gctgaggctg agggcctgcg tgctgctttg gctggggctg aggttgtccg    900

gaagaacttg gaagagggga gccagcggga gctggaagag gttcagaggc tgcaccaaga    960

gcagctgtcc tctttgacac aggctcacga ggaggctctt tccagtttga ccagcaaggc   1020

tgagggcttg gagaagtctc tgagtagtct ggaaaccaga agagcagggg aagccaagga   1080

gctggccgag gctcagaggg aggccgagct gcttcggaag cagctgagca agacccagga   1140

agacttggag gctcaggtga ccctggttga gaatctaaga aaatatgttg gggaacaagt   1200

cccttctgag gtccacagcc agacatggga actggagcga cagaagcttc tggaaaccat   1260

gcagcacttg caggaggacc gggacagcct gcatgccacc gcggagctgc tgcaggtgcg   1320

ggtgcagagc ctcacacaca tcctcgccct gcaggaggag gagctgacca ggaaggttca   1380

accttcagat tccctggagc ctgagtttac caggaagtgc cagtccctgc tgaaccgctg   1440

gcgggagaag gtgtttgccc tcatggtgca gctaaaggcc caggagctgg aacacagtga   1500

ctctgttaag cagctgaagg gacaggtggc ctcactccag gaaaaagtga catcccagag   1560

ccaggagcag gccatcctgc agcgatccct gcaggacaaa gccgcagagg tggaggtgga   1620

gcgtatgggt gccaagggcc tgcagttgga gctgagccgt gctcaggagg ccaggcgtca   1680

gtggcagcag cagacagcct cagccgagga gcagctgagg cttgtggtca atgctgtcag   1740

cagctctcag atctggctcg agaccaccat ggctaaggtg gaaggggctg ccgcccagct   1800

tcccagcctc aacaaccgac tcagctatgc tgtccgcaag gtcctcacca ttcggggcct   1860

gattgctcga aagcttgccc ttgctcagct gcgccaggag agctgtcccc taccaccacc   1920

ggccacagat gtgagccttg agttgcagca gctgcgggaa gaacggaacc gcctggatgc   1980

agaactgcag ctgagtgccc gcctcatcca gcaggaggtg ggccgggctc gggagcaagg   2040

ggaggcagag cggcagcagc tgagcaaggt ggcccagcag ctggagcagg agctgcagca   2100

gacccaggag tccctggcta gcttggggct gcagctggag gtagcacgcc agggccagca   2160

ggagagcaca gaggaggctg ccagtctgcg gcaggagctg acccagcagc aggaactcta   2220

cgggcaagcc ctgcaagaaa aggtggctga agtggaaact cggctgcggg agcaactctc   2280

agacacagag aggaggctga acgaggctcg gagggagcat gccaaggccg tggtctcctt   2340

acgccagatt cagcgcagag ccgcccagga aaaggagcgg agccaggaac tcaggcgtct   2400

gcaggaggag gcccggaagg aggaggggca gcgactggcc cggcgcttgc aggagctaga   2460

gagggataag aacctcatgc tggccacctt gcagcaggaa ggtctcctct cccgttacaa   2520

gcagcagcga ctgttgacag ttcttccttc cctactggat aagaagaaat ctgtggtgtc   2580

cagccccagg cctccagagt gttcagcatc tgcacctgta gcagcagcag tgcccaccag   2640

ggagtccata aaagggtccc tctctgtcct gctcgatgac ctgcaggacc tgagtgaagc   2700

catttccaaa gaggaagctg tttgtcaagg agacaacctt gacagatgct ccagctccaa   2760

tccccagatg agcagctaag cagctgacag ttggagggaa agccagcctg ggggctggga   2820

ggatcctgga gaagtgggtg gggacagacc agcccttccc catcctgggg ttgccctggg   2880

ggataccagc tgagtctgaa ttctgctcta aataaagacg actacagagg gaaaaaaaaa   2940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                 2972


<210>  1479
<211>  782
<212>  PRT
<213>  Homosapiens

<400>  1479

Met Phe Pro Pro Ser Gly Ser Thr Gly Leu Ile Pro Pro Ser His Phe 
1               5                   10                  15      


Gln Ala Arg Pro Leu Ser Thr Leu Pro Arg Met Ala Pro Thr Trp Leu 
            20                  25                  30          


Ser Asp Ile Pro Leu Val Gln Pro Pro Gly Tyr Gln Asp Val Ser Glu 
        35                  40                  45              


Arg Arg Leu Asp Thr Gln Arg Pro Gln Val Thr Met Trp Glu Arg Asp 
    50                  55                  60                  


Val Ser Ser Asp Arg Gln Glu Pro Gly Arg Arg Gly Arg Ser Trp Gly 
65                  70                  75                  80  


Leu Glu Gly Ser Gln Ala Leu Ser Gln Gln Ala Glu Val Ile Val Arg 
                85                  90                  95      


Gln Leu Gln Glu Leu Arg Arg Leu Glu Glu Glu Val Arg Leu Leu Arg 
            100                 105                 110         


Glu Thr Ser Leu Gln Gln Lys Met Arg Leu Glu Ala Gln Ala Met Glu 
        115                 120                 125             


Leu Glu Ala Leu Ala Arg Ala Glu Lys Ala Gly Arg Ala Glu Ala Glu 
    130                 135                 140                 


Gly Leu Arg Ala Ala Leu Ala Gly Ala Glu Val Val Arg Lys Asn Leu 
145                 150                 155                 160 


Glu Glu Gly Ser Gln Arg Glu Leu Glu Glu Val Gln Arg Leu His Gln 
                165                 170                 175     


Glu Gln Leu Ser Ser Leu Thr Gln Ala His Glu Glu Ala Leu Ser Ser 
            180                 185                 190         


Leu Thr Ser Lys Ala Glu Gly Leu Glu Lys Ser Leu Ser Ser Leu Glu 
        195                 200                 205             


Thr Arg Arg Ala Gly Glu Ala Lys Glu Leu Ala Glu Ala Gln Arg Glu 
    210                 215                 220                 


Ala Glu Leu Leu Arg Lys Gln Leu Ser Lys Thr Gln Glu Asp Leu Glu 
225                 230                 235                 240 


Ala Gln Val Thr Leu Val Glu Asn Leu Arg Lys Tyr Val Gly Glu Gln 
                245                 250                 255     


Val Pro Ser Glu Val His Ser Gln Thr Trp Glu Leu Glu Arg Gln Lys 
            260                 265                 270         


Leu Leu Glu Thr Met Gln His Leu Gln Glu Asp Arg Asp Ser Leu His 
        275                 280                 285             


Ala Thr Ala Glu Leu Leu Gln Val Arg Val Gln Ser Leu Thr His Ile 
    290                 295                 300                 


Leu Ala Leu Gln Glu Glu Glu Leu Thr Arg Lys Val Gln Pro Ser Asp 
305                 310                 315                 320 


Ser Leu Glu Pro Glu Phe Thr Arg Lys Cys Gln Ser Leu Leu Asn Arg 
                325                 330                 335     


Trp Arg Glu Lys Val Phe Ala Leu Met Val Gln Leu Lys Ala Gln Glu 
            340                 345                 350         


Leu Glu His Ser Asp Ser Val Lys Gln Leu Lys Gly Gln Val Ala Ser 
        355                 360                 365             


Leu Gln Glu Lys Val Thr Ser Gln Ser Gln Glu Gln Ala Ile Leu Gln 
    370                 375                 380                 


Arg Ser Leu Gln Asp Lys Ala Ala Glu Val Glu Val Glu Arg Met Gly 
385                 390                 395                 400 


Ala Lys Gly Leu Gln Leu Glu Leu Ser Arg Ala Gln Glu Ala Arg Arg 
                405                 410                 415     


Gln Trp Gln Gln Gln Thr Ala Ser Ala Glu Glu Gln Leu Arg Leu Val 
            420                 425                 430         


Val Asn Ala Val Ser Ser Ser Gln Ile Trp Leu Glu Thr Thr Met Ala 
        435                 440                 445             


Lys Val Glu Gly Ala Ala Ala Gln Leu Pro Ser Leu Asn Asn Arg Leu 
    450                 455                 460                 


Ser Tyr Ala Val Arg Lys Val Leu Thr Ile Arg Gly Leu Ile Ala Arg 
465                 470                 475                 480 


Lys Leu Ala Leu Ala Gln Leu Arg Gln Glu Ser Cys Pro Leu Pro Pro 
                485                 490                 495     


Pro Ala Thr Asp Val Ser Leu Glu Leu Gln Gln Leu Arg Glu Glu Arg 
            500                 505                 510         


Asn Arg Leu Asp Ala Glu Leu Gln Leu Ser Ala Arg Leu Ile Gln Gln 
        515                 520                 525             


Glu Val Gly Arg Ala Arg Glu Gln Gly Glu Ala Glu Arg Gln Gln Leu 
    530                 535                 540                 


Ser Lys Val Ala Gln Gln Leu Glu Gln Glu Leu Gln Gln Thr Gln Glu 
545                 550                 555                 560 


Ser Leu Ala Ser Leu Gly Leu Gln Leu Glu Val Ala Arg Gln Gly Gln 
                565                 570                 575     


Gln Glu Ser Thr Glu Glu Ala Ala Ser Leu Arg Gln Glu Leu Thr Gln 
            580                 585                 590         


Gln Gln Glu Leu Tyr Gly Gln Ala Leu Gln Glu Lys Val Ala Glu Val 
        595                 600                 605             


Glu Thr Arg Leu Arg Glu Gln Leu Ser Asp Thr Glu Arg Arg Leu Asn 
    610                 615                 620                 


Glu Ala Arg Arg Glu His Ala Lys Ala Val Val Ser Leu Arg Gln Ile 
625                 630                 635                 640 


Gln Arg Arg Ala Ala Gln Glu Lys Glu Arg Ser Gln Glu Leu Arg Arg 
                645                 650                 655     


Leu Gln Glu Glu Ala Arg Lys Glu Glu Gly Gln Arg Leu Ala Arg Arg 
            660                 665                 670         


Leu Gln Glu Leu Glu Arg Asp Lys Asn Leu Met Leu Ala Thr Leu Gln 
        675                 680                 685             


Gln Glu Gly Leu Leu Ser Arg Tyr Lys Gln Gln Arg Leu Leu Thr Val 
    690                 695                 700                 


Leu Pro Ser Leu Leu Asp Lys Lys Lys Ser Val Val Ser Ser Pro Arg 
705                 710                 715                 720 


Pro Pro Glu Cys Ser Ala Ser Ala Pro Val Ala Ala Ala Val Pro Thr 
                725                 730                 735     


Arg Glu Ser Ile Lys Gly Ser Leu Ser Val Leu Leu Asp Asp Leu Gln 
            740                 745                 750         


Asp Leu Ser Glu Ala Ile Ser Lys Glu Glu Ala Val Cys Gln Gly Asp 
        755                 760                 765             


Asn Leu Asp Arg Cys Ser Ser Ser Asn Pro Gln Met Ser Ser 
    770                 775                 780         


<210>  1480
<211>  1080
<212>  DNA
<213>  Homosapiens

<400>  1480
atgctgccct gcttccaact gctgcgcata gggggcggca ggggcggtga tctctacacc     60

ttccaccccc ccgccggggt tggctgcacc tatcgcttgg gccacagggc cgacctgtgt    120

gatgtggccc tgcggcccca gcaggagcct ggcctcatct ctgggatcca cgccgaactg    180

catgccgagc cccggggtga tgactggagg gtcagcctgg aagaccacag cagccaaggt    240

actttggtca ataatgtccg actcccaaga ggtcacaggc tggaattgag tgatggagac    300

ctcctgacct ttggccctga agggccccca ggaaccagcc cctcggagtt ctacttcatg    360

ttccaacaag tacgagtcaa gcctcaggac tttgctgcca ttaccatccc acggtctagg    420

ggagaagccc gggttggggc tggtttccgg cctatgctgc cctcccaggg ggctccacag    480

cggcctctca gcaccttctc ccctgccccc aaggccacac tgatcctaaa ctccataggc    540

agcctcagca agctccggcc ccagcccctc accttctccc ctagttgggg tggaccaaag    600

agcctgcctg ttcccgcccc acctggggaa gtggggacca cgccttctgc tccaccccaa    660

cgcaatcgga ggaaatctgt tcaccgagtg ttggcggaac tggatgatga gagtgagcct    720

cctgagaacc cgccaccggt ccttatggag cccaggaaga aactccgtgt agacaaagcc    780

ccactgactc ccactggaaa tgcacgtggc cgtcctcgga agtacccagt gagcgctccc    840

atggctcccc ctgcagttgg ggcggggagc cctgtgcagc tccttgttgc tgcctgcccc    900

aggaagagac agtggcctgg gttcagtgtg atggctgtga cgtctggttc catgtggcct    960

gtgttggctg cagcatccag gctgccaggg aggccgactt ccgatgccca gggtgccggg   1020

ctggcattca gcctaaggtc caccgccaag gcaccatcgg acacacctgc ccatgagtag   1080


<210>  1481
<211>  359
<212>  PRT
<213>  Homosapiens

<400>  1481

Met Leu Pro Cys Phe Gln Leu Leu Arg Ile Gly Gly Gly Arg Gly Gly 
1               5                   10                  15      


Asp Leu Tyr Thr Phe His Pro Pro Ala Gly Val Gly Cys Thr Tyr Arg 
            20                  25                  30          


Leu Gly His Arg Ala Asp Leu Cys Asp Val Ala Leu Arg Pro Gln Gln 
        35                  40                  45              


Glu Pro Gly Leu Ile Ser Gly Ile His Ala Glu Leu His Ala Glu Pro 
    50                  55                  60                  


Arg Gly Asp Asp Trp Arg Val Ser Leu Glu Asp His Ser Ser Gln Gly 
65                  70                  75                  80  


Thr Leu Val Asn Asn Val Arg Leu Pro Arg Gly His Arg Leu Glu Leu 
                85                  90                  95      


Ser Asp Gly Asp Leu Leu Thr Phe Gly Pro Glu Gly Pro Pro Gly Thr 
            100                 105                 110         


Ser Pro Ser Glu Phe Tyr Phe Met Phe Gln Gln Val Arg Val Lys Pro 
        115                 120                 125             


Gln Asp Phe Ala Ala Ile Thr Ile Pro Arg Ser Arg Gly Glu Ala Arg 
    130                 135                 140                 


Val Gly Ala Gly Phe Arg Pro Met Leu Pro Ser Gln Gly Ala Pro Gln 
145                 150                 155                 160 


Arg Pro Leu Ser Thr Phe Ser Pro Ala Pro Lys Ala Thr Leu Ile Leu 
                165                 170                 175     


Asn Ser Ile Gly Ser Leu Ser Lys Leu Arg Pro Gln Pro Leu Thr Phe 
            180                 185                 190         


Ser Pro Ser Trp Gly Gly Pro Lys Ser Leu Pro Val Pro Ala Pro Pro 
        195                 200                 205             


Gly Glu Val Gly Thr Thr Pro Ser Ala Pro Pro Gln Arg Asn Arg Arg 
    210                 215                 220                 


Lys Ser Val His Arg Val Leu Ala Glu Leu Asp Asp Glu Ser Glu Pro 
225                 230                 235                 240 


Pro Glu Asn Pro Pro Pro Val Leu Met Glu Pro Arg Lys Lys Leu Arg 
                245                 250                 255     


Val Asp Lys Ala Pro Leu Thr Pro Thr Gly Asn Ala Arg Gly Arg Pro 
            260                 265                 270         


Arg Lys Tyr Pro Val Ser Ala Pro Met Ala Pro Pro Ala Val Gly Ala 
        275                 280                 285             


Gly Ser Pro Val Gln Leu Leu Val Ala Ala Cys Pro Arg Lys Arg Gln 
    290                 295                 300                 


Trp Pro Gly Phe Ser Val Met Ala Val Thr Ser Gly Ser Met Trp Pro 
305                 310                 315                 320 


Val Leu Ala Ala Ala Ser Arg Leu Pro Gly Arg Pro Thr Ser Asp Ala 
                325                 330                 335     


Gln Gly Ala Gly Leu Ala Phe Ser Leu Arg Ser Thr Ala Lys Ala Pro 
            340                 345                 350         


Ser Asp Thr Pro Ala His Glu 
        355                 


<210>  1482
<211>  1417
<212>  DNA
<213>  Homosapiens

<400>  1482
tcccttcgca agccctcatt tcaccaggcc cccggcttgg ggcgccttcc ttccccatgg     60

cgggacacct ggcttcggat ttcgccttct cgccccctcc aggtggtgga ggtgatgggc    120

caggggggcc ggagccgggc tgggttgatc ctcggacctg gctaagcttc caaggccctc    180

ctggagggcc aggaatcggg ccgggggttg ggccaggctc tgaggtgtgg gggattcccc    240

catgcccccc gccgtatgag ttctgtgggg ggatggcgta ctgtgggccc caggttggag    300

tggggctagt gccccaaggc ggcttggaga cctctcagcc tgagggcgaa gcaggagtcg    360

gggtggagag caactccgat ggggcctccc cggagccctg caccgtcacc cctggtgccg    420

tgaagctgga gaaggagaag ctggagcaaa acccggagga gtcccaggac atcaaagctc    480

tgcagaaaga actcgagcaa tttgccaagc tcctgaagca gaagaggatc accctgggat    540

atacacaggc cgatgtgggg ctcaccctgg gggttctatt tgggaaggta ttcagccaaa    600

cgaccatctg ccgctttgag gctctgcagc ttagcttcaa gaacatgtgt aagctgcggc    660

ccttgctgca gaagtgggtg gaggaagctg acaacaatga aaatcttcag gagatatgca    720

aagcagaaac cctcgtgcag gcccgaaaga gaaagcgaac cagtatcgag aaccgagtga    780

gaggcaacct ggagaatttg ttcctgcagt gcccgaaacc cacactgcag cagatcagcc    840

acatcgccca gcagcttggg ctcgagaagg atgtggtccg agtgtggttc tgtaaccggc    900

gccagaaggg caagcgatca agcagcgact atgcacaacg agaggatttt gaggctgctg    960

ggtctccttt ctcaggggga ccagtgtcct ttcctctggc cccagggccc cattttggta   1020

ccccaggcta tgggagccct cacttcactg cactgtactc ctcggtccct ttccctgagg   1080

gggaagcctt tccccctgtc tccgtcacca ctctgggctc tcccatgcat tcaaactgag   1140

gtgcctgccc ttctaggaat gggggacagg gggaggggag gagctaggga aagaaaacct   1200

ggagtttgtg ccagggtttt tgggattaag ttcttcattc actaaggaag gaattgggaa   1260

cacaaagggt gggggcaggg gagtttgggg caactggttg gagggaaggt gaagttcaat   1320

gatgctcttg attttaatcc cacatcatgt atcacttttt tcttaaataa agaagcctgg   1380

gacacagtaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                            1417


<210>  1483
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  1483

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  1484
<211>  1177
<212>  DNA
<213>  Homosapiens

<400>  1484
gtagtccttt gttacatgca tgagtcagtg aacagggaat gggtgaatga catttgtggg     60

taggttattt ctagaagtta ggtgggcagc ttggaaggca gaggcacttc tacagactat    120

tccttggggc cacacgtagg ttcttgaatc ccgaatggaa aggggagatt gataactggt    180

gtgtttatgt tcttacaagt cttctgcctt ttaaaatcca gtcccaggac atcaaagctc    240

tgcagaaaga actcgagcaa tttgccaagc tcctgaagca gaagaggatc accctgggat    300

atacacaggc cgatgtgggg ctcaccctgg gggttctatt tgggaaggta ttcagccaaa    360

cgaccatctg ccgctttgag gctctgcagc ttagcttcaa gaacatgtgt aagctgcggc    420

ccttgctgca gaagtgggtg gaggaagctg acaacaatga aaatcttcag gagatatgca    480

aagcagaaac cctcgtgcag gcccgaaaga gaaagcgaac cagtatcgag aaccgagtga    540

gaggcaacct ggagaatttg ttcctgcagt gcccgaaacc cacactgcag cagatcagcc    600

acatcgccca gcagcttggg ctcgagaagg atgtggtccg agtgtggttc tgtaaccggc    660

gccagaaggg caagcgatca agcagcgact atgcacaacg agaggatttt gaggctgctg    720

ggtctccttt ctcaggggga ccagtgtcct ttcctctggc cccagggccc cattttggta    780

ccccaggcta tgggagccct cacttcactg cactgtactc ctcggtccct ttccctgagg    840

gggaagcctt tccccctgtc tccgtcacca ctctgggctc tcccatgcat tcaaactgag    900

gtgcctgccc ttctaggaat gggggacagg gggaggggag gagctaggga aagaaaacct    960

ggagtttgtg ccagggtttt tgggattaag ttcttcattc actaaggaag gaattgggaa   1020

cacaaagggt gggggcaggg gagtttgggg caactggttg gagggaaggt gaagttcaat   1080

gatgctcttg attttaatcc cacatcatgt atcacttttt tcttaaataa agaagcctgg   1140

gacacagtaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                            1177


<210>  1485
<211>  164
<212>  PRT
<213>  Homosapiens

<400>  1485

Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val Glu Glu Ala Asp 
1               5                   10                  15      


Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu Thr Leu Val Gln 
            20                  25                  30          


Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg Val Arg Gly Asn 
        35                  40                  45              


Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr Leu Gln Gln Ile 
    50                  55                  60                  


Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp Val Val Arg Val 
65                  70                  75                  80  


Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser Ser Ser Asp Tyr 
                85                  90                  95      


Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro Phe Ser Gly Gly 
            100                 105                 110         


Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe Gly Thr Pro Gly 
        115                 120                 125             


Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser Val Pro Phe Pro 
    130                 135                 140                 


Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr Leu Gly Ser Pro 
145                 150                 155                 160 


Met His Ser Asn 
                


<210>  1486
<211>  1719
<212>  DNA
<213>  Homosapiens

<400>  1486
atttctctac tcacctgtct ccgaatccgc cgtggtgttt caagcgagtc aagattccag     60

acgcgcccca ggctggactc ggaattactg ccccgcgggt ctgcattttc acagcggcag    120

gtggcttgtg gtccctgaca aggaggaccc tgagggcaac cacaccttgc catgcagagc    180

acctggcttc tcatctgcca acctcactct gacccggctg caggaaggga aggagccaac    240

cccggactca agactcaagg ggaccagaac cagggagatg agacatacca gggctgggca    300

gctgtggggg tccttccaga gaggagctga gatacgccta cctggagggg cccctgggcc    360

tggaggggct cctcagtgtg actgggtgaa gtgttttcag aggaccaggg ttgaggttgg    420

gggcatctca tccagaccct gccggcatct gcccccagaa cccaagggcc cctccttcct    480

ccctcctcga tggaaatgct ggggatgtcc tcagtcaccc tctgagcact cacacatcac    540

cccttatttg gaaatttttc tcactctaac cttccttcct gctgcacctt ctgccccatc    600

cccaggctct ggcctctctc tctcctcttc taccctttag caggtaatga ctcagttccc    660

actgaggagc cagctgtagg tgagagtctg ggctctcggt gaggttggga gaaggaaaag    720

gcttatgggc cagggggtgg gagggagaat gggcacagcc agagcagagt ggaagggttg    780

ggggaggcga taaagacaga tgtttccgta ttaccatttt tctttcatgg tccgagggag    840

ctgcccttcc cccaagccca ggaaagtgaa aagagaagca ggaacagtaa aatactccac    900

aggaaagaaa aatcttagtg atccctcctg ctgtctcttt ccttttgcct attctggcaa    960

attttgtaag tgaaatttgt taccaagatg tgaaaatctt ataagaaagt ctctaaatat   1020

ttgagaataa aattatcaat gtctcagctc tgcaggctga aaaaacggag gctttacaaa   1080

ataaaatcat gcttggaaaa cttctcctct gagggatgtc aaaggctgca ctgaataagc   1140

tgtaaggtgg tgctgaaatg ggtcatttat ttgcctgtgt aagctcaggc aggtgttgga   1200

attgaggaag tataggtaat gaaaaaagta accatgtcct cgggacatag cgactggtga   1260

tgaccacaca atcaacacaa taaactctag cattcacatt gtagtccagc tcattcaagc   1320

aaagctatct ccaataggga gtttaccctg tacagaacac gtgcatttcc acctgttctc   1380

agactgaccc tttgctcatc acaatagtga aaaaaaacac agccctgggt ggagatttaa   1440

gatgctaatg agtcatgaga cgtatgaaca agcatgtaca gctactgcac acgtgcaccc   1500

agaagaccgc ccagaacatg cttgctagta acacctcttc ccacccacct cctgtaaata   1560

atcatgtaag actcccataa agggagtttc tccagcagtg atcaatgctg tctcatcctt   1620

aggagcagcc caccctgaat cctctcaggg tgtacagttt attttgcact taactttcaa   1680

aataatattt ttcctttgta ataaattgct ttgtacttc                          1719


<210>  1487
<211>  120
<212>  PRT
<213>  Homosapiens

<400>  1487

Met Arg His Thr Arg Ala Gly Gln Leu Trp Gly Ser Phe Gln Arg Gly 
1               5                   10                  15      


Ala Glu Ile Arg Leu Pro Gly Gly Ala Pro Gly Pro Gly Gly Ala Pro 
            20                  25                  30          


Gln Cys Asp Trp Val Lys Cys Phe Gln Arg Thr Arg Val Glu Val Gly 
        35                  40                  45              


Gly Ile Ser Ser Arg Pro Cys Arg His Leu Pro Pro Glu Pro Lys Gly 
    50                  55                  60                  


Pro Ser Phe Leu Pro Pro Arg Trp Lys Cys Trp Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Pro Ser Glu His Ser His Ile Thr Pro Tyr Leu Glu Ile Phe Leu Thr 
                85                  90                  95      


Leu Thr Phe Leu Pro Ala Ala Pro Ser Ala Pro Ser Pro Gly Ser Gly 
            100                 105                 110         


Leu Ser Leu Ser Ser Ser Thr Leu 
        115                 120 


<210>  1488
<211>  1543
<212>  DNA
<213>  Homosapiens

<400>  1488
ggccgagatg cgggtcatgg cgccccgagc cctcctcctg ctgctctcgg gaggcctggc     60

cctgaccgag acctgggcct gctcccactc catgaggtat ttcgacaccg ccgtgtcccg    120

gcccggccgc ggagagcccc gcttcatctc agtgggctac gtggacgaca cgcagttcgt    180

gcggttcgac agcgacgccg cgagtccgag aggggagccg cgggcgccgt gggtggagca    240

ggaggggccg gagtattggg accgggagac acagaagtac aagcgccagg cacaggctga    300

ccgagtgagc ctgcggaacc tgcgcggcta ctacaaccag agcgaggacg ggtctcacac    360

cctccagagg atgtctggct gcgacctggg gcccgacggg cgcctcctcc gcgggtatga    420

ccagtccgcc tacgacggca aggattacat cgccctgaac gaggacctgc gctcctggac    480

cgccgcggac accgcggctc agatcaccca gcgcaagttg gaggcggccc gtgcggcgga    540

gcagctgaga gcctacctgg agggcacgtg cgtggagtgg ctccgcagat acctggagaa    600

cgggaaggag acgctgcagc gcgcagaacc cccaaagaca cacgtgaccc accaccccct    660

ctctgaccat gaggccaccc tgaggtgctg ggccctgggc ttctaccctg cggagatcac    720

actgacctgg cagcgggatg gggaggacca gacccaggac accgagcttg tggagaccag    780

gccagcagga gatggaacct tccagaagtg ggcagctgtg gtggtgcctt ctggacaaga    840

gcagagatac acgtgccata tgcagcacga ggggctgcaa gagcccctca ccctgagctg    900

ggagccatct tcccagccca ccatccccat catgggcatc gttgctggcc tggctgtcct    960

ggttgtccta gctgtccttg gagctgtggt caccgctatg atgtgtagga ggaagagctc   1020

aggtggaaaa ggagggagct gctctcaggc tgcgtgcagc aacagtgccc agggctctga   1080

tgagtctctc atcacttgta aagcctgaga cagctgcctg tgtgggactg agatgcagga   1140

tttcttcaca cctctccttt gtgacttcaa gagcctctgg catctctttc tgcaaaggca   1200

cctgaatgtg tctgcgttcc tgttagcata atgtgaggag gtggagagac agcccacccc   1260

cgtgtccacc gtgacccctg tccccacact gacctgtgtt ccctccccga tcatctttcc   1320

tgttccagag aggtggggct ggatgtctcc atctctgtct caaattcatg gtgcactgag   1380

ctgcaacttc ttacttccct aatgaagtta agaacctgaa tataaatttg tgttctcaaa   1440

tatttgctat gaagcgttga tggattaatt aaataagtca attcctagaa gttgagagag   1500

caaataaaga cctgagaacc ttccaaaaaa aaaaaaaaaa aaa                     1543


<210>  1489
<211>  366
<212>  PRT
<213>  Homosapiens

<400>  1489

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Ser Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala 
        355                 360                 365     


<210>  1490
<211>  1533
<212>  DNA
<213>  Homosapiens

<400>  1490
atgctggtca tggcgccccg aaccgtcctc ctgctgctct cggcggccct ggccctgacc     60

gagacctggg ccggctccca ctccatgagg tatttctaca cctccgtgtc ccggcccggc    120

cgcggggagc cccgcttcat ctcagtgggc tacgtggacg acacccagtt cgtgaggttc    180

gacagcgacg ccgcgagtcc gagagaggag ccgcgggcgc cgtggataga gcaggagggg    240

ccggagtatt gggaccggaa cacacagatc tacaaggccc aggcacagac tgaccgagag    300

agcctgcgga acctgcgcgg ctactacaac cagagcgagg ccgggtctca caccctccag    360

agcatgtacg gctgcgacgt ggggccggac gggcgcctcc tccgcgggca tgaccagtac    420

gcctacgacg gcaaggatta catcgccctg aacgaggacc tgcgctcctg gaccgccgcg    480

gacacggcgg ctcagatcac ccagcgcaag tgggaggcgg cccgtgaggc ggagcagcgg    540

agagcctacc tggagggcga gtgcgtggag tggctccgca gatacctgga gaacgggaag    600

gacaagctgg agcgcgctga ccccccaaag acacacgtga cccaccaccc catctctgac    660

catgaggcca ccctgaggtg ctgggccctg ggtttctacc ctgcggagat cacactgacc    720

tggcagcggg atggcgagga ccaaactcag gacactgagc ttgtggagac cagaccagca    780

ggagatagaa ccttccagaa gtgggcagct gtggtggtgc cttctggaga agagcagaga    840

tacacatgcc atgtacagca tgaggggctg ccgaagcccc tcaccctgag atgggagccg    900

tcttcccagt ccaccgtccc catcgtgggc attgttgctg gcctggctgt cctagcagtt    960

gtggtcatcg gagctgtggt cgctgctgtg atgtgtagga ggaagagttc aggtggaaaa   1020

ggagggagct actctcaggc tgcgtgcagc gacagtgccc agggctctga tgtgtctctc   1080

acagcttgaa aagcctgaga cagctgtctt gtgagggact gagatgcagg atttcttcac   1140

gcctcccctt tgtgacttca agagcctctg gcatctcttt ctgcaaaggc acctgaatgt   1200

gtctgcgtcc ctgttagcat aatgtgagga ggtggagaga cagcccaccc ttgtgtccac   1260

tgtgacccct gttcccatgc tgacctgtgt ttcctcccca gtcatctttc ttgttccaga   1320

gaggtggggc tggatgtctc catctctgtc tcaactttac gtgcactgag ctgcaacttc   1380

ttacttccct actgaaaata agaatctgaa tataaatttg ttttctcaaa tatttgctat   1440

gagaggttga tggattaatt aaataagtca attcctggaa tttgaaagag caaataaaga   1500

cctgagaacc ttccagaaaa aaaaaaaaaa aaa                                1533


<210>  1491
<211>  362
<212>  PRT
<213>  Homosapiens

<400>  1491

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  1492
<211>  1365
<212>  DNA
<213>  Homosapiens

<400>  1492
cactgcttga gccgctgaga gggtggcgac gtcggggcca tggggctggg cccggtcttc     60

ctgcttctgg ctggcatctt cccttttgca cctccgggag ctgctgctga gccccacagt    120

cttcgttata acctcacggt gctgtcctgg gatggatctg tgcagtcagg gtttctcact    180

gaggtacatc tggatggtca gcccttcctg cgctgtgaca ggcagaaatg cagggcaaag    240

ccccagggac agtgggcaga agatgtcctg ggaaataaga catgggacag agagaccaga    300

gacttgacag ggaacggaaa ggacctcagg atgaccctgg ctcatatcaa ggaccagaaa    360

gaaggcttgc attccctcca ggagattagg gtctgtgaga tccatgaaga caacagcacc    420

aggagctccc agcatttcta ctacgatggg gagctcttcc tctcccaaaa cctggagact    480

aaggaatgga caatgcccca gtcctccaga gctcagacct tggccatgaa cgtcaggaat    540

ttcttgaagg aagatgccat gaagaccaag acacactatc acgctatgca tgcagactgc    600

ctgcaggaac tacggcgata tctaaaatcc ggcgtagtcc tgaggagaac agtgcccccc    660

atggtgaatg tcacccgcag cgaggcctca gagggcaaca ttaccgtgac atgcagggct    720

tctggcttct atccctggaa tatcacactg agctggcgtc aggatggggt atctttgagc    780

cacgacaccc agcagtgggg ggatgtcctg cctgatggga atggaaccta ccagacctgg    840

gtggccacca ggatttgcca aggagaggag cagaggttca cctgctacat ggaacacagc    900

gggaatcaca gcactcaccc tgtgccctct gggaaagtgc tggtgcttca gagtcattgg    960

cagacattcc atgtttctgc tgttgctgct gctgctattt ttgttattat tattttctat   1020

gtccgttgtt gtaagaagaa aacatcagct gcagagggtc cagagctcgt gagcctgcag   1080

gtcctggatc aacacccagt tgggacgagt gaccacaggg atgccacaca gctcggattt   1140

cagcctctga tgtcagatct tgggtccact ggctccactg agggcgccta gactctacag   1200

ccaggcagct gggattcaat tccctgcctg gatctcacga gcactttccc tcttggtgcc   1260

tcagtttcct gacctatgaa acagagaaaa taaaagcact tatttattgt tgttggaggc   1320

tgcaaaatgt tagtagatat gaggcgtttg cagctgtacc atatt                   1365


<210>  1493
<211>  383
<212>  PRT
<213>  Homosapiens

<400>  1493

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Lys Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ile 
305                 310                 315                 320 


Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Asp Leu Gly Ser Thr Gly Ser Thr Glu Gly Ala 
    370                 375                 380             


<210>  1494
<211>  2451
<212>  DNA
<213>  Homosapiens

<400>  1494
ctcagattct ccccagacgc caaggttgcg ggtcatggag tcccgaaccc tcctcctgct     60

gttctcggga gccgtggccc tgatccagac ctgggcagat tacaattaca atcaaggcag    120

aaatgatctc atttttacat tacaactctg gaaaaggcaa tagactgaga tgcaagtgtg    180

cccccaagtg atgggcagaa ggagagaagg tgttttggat gcattctaga acacaggtaa    240

tctaaggaga gttgatcaag gccgtggaag agtcctccag ccactattgg ccatcaaagg    300

agtcctctgt gtcccaggaa tggtcctgct ttggtgtccc tggtgtgacc catcacccgc    360

tgggaacagc ctgagagaag tagggcctct gcaccaatgc tgctgaggat gtcagagcac    420

aggaacgagg ccttgggaaa ttacctggaa atgcgactga aatcttcctt cctgaggggt    480

ctgggctctt ggaaatcaaa ccctctcagg ttgggtggct ggacgattct cctcacactt    540

acaatgggac aaggggaacc aggaggcccc caaggggatc cctgggttcc acacgaactc    600

ctcctaccct cattgtgtga cagcagccat gcctcctcct ggggatcagg atctattacc    660

tgtgcctgga gaggagggga ctcctcttct cacccgctgg tctctggaca catactgtcc    720

aattcccctg tggcagctgt aatgtgtagt tcaatgggca ctcatttgtc cccttttaag    780

ggtaccctcc tttagaatcc aggaccttct accctgcaga gtgttgtttt gggagagaag    840

tgcaaaatcc cacgacaggt gagttgaagg aatgggatat ggagccacat ccacttccac    900

cccttggtat ctggacccac gtgttcttcc tactgagatt acagaactgt agagatgtct    960

ttgattttta aaatgcacca tgtcctgaaa gatggcaccc tcccacccgc agagtgcttc   1020

ctgcaagctg gcgttgagct gtgcctatag aagctctttt caacattctt tatggtcagc   1080

agcccttggt tggtgcagat ggtgatagga ccagtgggtc ccacagcatg gccacactgc   1140

acctccttcg ctgtcaagtg ggtcccccac gaagatactg cacggagagc agtgccaagc   1200

ctgtggatca ggaatatcaa cagcccccag agagtggtgc tggctgaggg tctgagagca   1260

ggacaggaaa acccacctat ggaataggtg cctatccctg tgaagatgaa cctctggccc   1320

ttccaggatg gaaggagtgc aatgtagtca actcctcact tagggtctgg ttggtcacct   1380

aaagaaatag agccctacca gggaagatca ttgggttcaa atgctgatga gtaggacatt   1440

tagaggtggc agtgtctgga tctaccttgg taggagggag tcagtactgt tggacccata   1500

ggtagcctca tccctgccac tgtgtttgct ccatttatgt acccatccta cccggcctgg   1560

gctgacccat ggggaaggct ggctaatttc agtgcttctg cttggttgtt cagggccatt   1620

tcaggtttgg gtgttttctg gggatgttaa catgggattc aggctcaact cacaagaaac   1680

ttttccatct catgatggat gctgttgggc atgtccaatg tatgacttca tgagttacac   1740

agatgctaat tcgtaggggc acttggaatc acatggttgt tttgtgtccc atggtcaagc   1800

attctatctt atcagggcct acagtaacat gccaaaagtt gcttccaaca tatttctctg   1860

ctttggatgg ggcatatttc tgtgctgtgg atgacatggc cttactccag aatcccaggc   1920

cctccactgt gactctccta ctggtgcttg gttcagctcc accccaaatc ttaccccacc   1980

actggcactt tcagcaccag ggggtctgaa ggatggtgac tgcgccatgg cctggatctg   2040

ctgcagtgtc ctttcctgtg gaggctccac tcaaagctgg catcctccta tgtcacctag   2100

agtgtgggtc aaagcaatac acctacatgt agaatgtgat gtcagaactc aaacaggctc   2160

accaggcagt gtgcttcctt ccttgcatga ggatgcaaga tgcaacagtt tgtctttcac   2220

attggaaggg acacccctgg atgcccctaa ccactagacc tgtaaaactt cactgcagtg   2280

gccacttctg aatctctgta aggtttattt atcttcaccc tctggagaga agatgtttta   2340

ccaaagcctc tagtgtacct tcctcctctt actcatccat cccagtcaac atgatgttgt   2400

caatgaaata aaggaattta atattctata gtaaaaaaaa aaaaaaaaaa a            2451


<210>  1495
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  1495

Met Leu Leu Arg Met Ser Glu His Arg Asn Glu Ala Leu Gly Asn Tyr 
1               5                   10                  15      


Leu Glu Met Arg Leu Lys Ser Ser Phe Leu Arg Gly Leu Gly Ser Trp 
            20                  25                  30          


Lys Ser Asn Pro Leu Arg Leu Gly Gly Trp Thr Ile Leu Leu Thr Leu 
        35                  40                  45              


Thr Met Gly Gln Gly Glu Pro Gly Gly Pro Gln Gly Asp Pro Trp Val 
    50                  55                  60                  


Pro His Glu Leu Leu Leu Pro Ser Leu Cys Asp Ser Ser His Ala Ser 
65                  70                  75                  80  


Ser Trp Gly Ser Gly Ser Ile Thr Cys Ala Trp Arg Gly Gly Asp Ser 
                85                  90                  95      


Ser Ser His Pro Leu Val Ser Gly His Ile Leu Ser Asn Ser Pro Val 
            100                 105                 110         


Ala Ala Val Met Cys Ser Ser Met Gly Thr His Leu Ser Pro Phe Lys 
        115                 120                 125             


Gly Thr Leu Leu 
    130         


<210>  1496
<211>  2385
<212>  DNA
<213>  Homosapiens

<400>  1496
gggccatggg gctgggccgg gtcctgctgt ttctggccgt cgccttccct tttgcacccc     60

cggcagccgc cgctgagccc cacagtcttc gttacaacct catggtgctg tcccaggatg    120

gatctgtgca gtcagggttt ctcgctgagg gacatctgga tggtcagccc ttcctgcgct    180

atgacaggca gaaacgcagg gcaaagcccc agggacagtg ggcagaagat gtcctgggag    240

ctgagacctg ggacacagag accgaggact tgacagagaa tgggcaagac ctcaggagga    300

ccctgactca tatcaaggac cagaaaggag gcttgcattc cctccaggag attagggtct    360

gtgagatcca tgaagacagc agcaccaggg gctcccggca tttctactac aatggggagc    420

tcttcctctc ccaaaacctg gagactcaag aatcgacagt gccccagtcc tccagagctc    480

agaccttggc tatgaacgtc acaaatttct ggaaggaaga tgccatgaag accaagacac    540

actatcgcgc tatgcaggca gactgcctgc agaaactaca gcgatatctg aaatccgggg    600

tggccatcag gagaacagtg ccccccatgg tgaatgtcac ctgcagcgag gtctcagagg    660

gcaacatcac cgtgacatgc agggcttcca gcttctatcc ccggaatatc acactgacct    720

ggcgtcagga tggggtatct ttgagccaca acacccagca gtggggggat gtcctgcctg    780

atgggaatgg aacctaccag acctgggtgg ccaccaggat tcgccaagga gaggagcaga    840

ggttcacctg ctacatggaa cacagcggga atcacggcac tcaccctgtg ccctctggga    900

aggcgctggt gcttcagagt caacggacag actttccata tgtttctgct gctatgccat    960

gttttgttat tattattatt ctctgtgtcc cttgttgcaa gaagaaaaca tcagcggcag   1020

agggtccaga gcttgtgagc ctgcaggtcc tggatcaaca cccagttggg acaggagacc   1080

acagggatgc agcacagctg ggatttcagc ctctgatgtc agctactggg tccactggtt   1140

ccactgaggg cgcctagact ctacagccag gcggccagga ttcaactccc tgcctggatc   1200

tcaccagcac tttccctctg tttcctgacc tatgaaacag aaaataacat cacttattta   1260

ttgttgttgg atgctgcaaa gtgttagtag gtatgaggtg tttgctgctc tgccacgtag   1320

agagccagca aagggatcat gaccaactca acattccatt ggaggctata tgatcaaaca   1380

gcaaattgtt tatcatgaat gcaggatgtg ggcaaactca cgactgctcc tgccaacaga   1440

aggtttgctg agggcattca ctccatggtg ctcattggag ttatctactg ggtcatctag   1500

agcctattgt ttgaggaatg cagtcttaca agcctactct ggacccagca gctgactcct   1560

tcttccaccc ctcttcttgc tatctcctat accaataaat acgaagggct gtggaagatc   1620

agagcccttg ttcacgagaa gcaagaagcc ccctgacccc ttgttccaaa tatactcttt   1680

tgtctttctc tttattccca cgttcgccct ttgttcagtc caatacaggg ttgtggggcc   1740

cttaacagtg ccatattaat tggtatcatt atttctgttg tttttgtttt tgtttttgtt   1800

tttgtttttg agacagagtc tcactctgtc acccaggctg cagttcactg gtgtgatctc   1860

agctcactgc aacctctgcc tcccaggttc aagcacttct cgtacctcag actcccgaat   1920

agctgggatt acagacaggc accaccacac ccagctaatt tttgtatttt ttgtagagac   1980

ggggtttcgc caagttgacc agcccagttt caaactcctg acctcaggtg atctgcctgc   2040

cttggcatcc caaagtgctg ggattacaag aatgagccac cgtgcctggc ctattttatt   2100

atattgtaat atattttatt atattagcca ccatgcctgt cctattttct tatgttttaa   2160

tatattttaa tatattacat gtgcagtaat tagattatca tgggtgaact ttatgagtga   2220

gtatcttggt gatgactcct cctgaccagc ccaggaccag ctttcttgtc accttgaggt   2280

cccctcgccc cgtcacaccg ttatgcatta ctctgtgtct actattatgt gtgcataatt   2340

tataccgtaa atgtttactc tttaaataga aaaaaaaaaa aaaaa                   2385


<210>  1497
<211>  383
<212>  PRT
<213>  Homosapiens

<400>  1497

Met Gly Leu Gly Arg Val Leu Leu Phe Leu Ala Val Ala Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Ala Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Met Val Leu Ser Gln Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Ala Glu 
65                  70                  75                  80  


Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu 
                85                  90                  95      


Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Ser Ser Thr Arg 
        115                 120                 125             


Gly Ser Arg His Phe Tyr Tyr Asn Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Gln Glu Ser Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys Leu Gln Lys Leu Gln 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Gly Thr His Pro Val Pro Ser Gly Lys Ala Leu Val Leu Gln 
    290                 295                 300                 


Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe 
305                 310                 315                 320 


Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Ala 
    370                 375                 380             


<210>  1498
<211>  709
<212>  DNA
<213>  Homosapiens

<400>  1498
agttcctggt ggccgttgga cagctcacac agctcccggc caggtcaccc gccatggtcc     60

tccctctgcc ctggctctct cggtaccatt tccttcgcct ccttctgccc tcctggtcct    120

tggcacccca gggctcccat gggtgctgct cccaaaaccc caaagcaagc atggaagagc    180

agaccaactc cagaggaaat gggaagatga cgtcccctcc caggggccct gggacccacc    240

gcacagctga gctggcccga gctgaagagt tgttggagca gcagctggag ctgtaccagg    300

ccctccttga agggcaggag ggagcctggg aggcccaagc cctggtgctc aagatccaga    360

agctgaagga acagatgagg aggcaccaag agagccttgg aggaggtgcc taagtttccc    420

ccagtgccca cagcaccctc cggcactgaa aatacacgca ccacccacca ggagccttgg    480

gatcataaac accccagcgt cttcccaggc cagagaaagt ggaagagacc acaaaccgca    540

ggcaattggc aggcagtggg ggagccaggg ctctgcagtc ttagtcccat tcccctttga    600

tctcacagca ggcagggcac ccaggcctta taggaattca ccctggacca tgccctaaaa    660

taacctcacc ccaaatacaa taaagggacg aagcacttat agataccac                709


<210>  1499
<211>  119
<212>  PRT
<213>  Homosapiens

<400>  1499

Met Val Leu Pro Leu Pro Trp Leu Ser Arg Tyr His Phe Leu Arg Leu 
1               5                   10                  15      


Leu Leu Pro Ser Trp Ser Leu Ala Pro Gln Gly Ser His Gly Cys Cys 
            20                  25                  30          


Ser Gln Asn Pro Lys Ala Ser Met Glu Glu Gln Thr Asn Ser Arg Gly 
        35                  40                  45              


Asn Gly Lys Met Thr Ser Pro Pro Arg Gly Pro Gly Thr His Arg Thr 
    50                  55                  60                  


Ala Glu Leu Ala Arg Ala Glu Glu Leu Leu Glu Gln Gln Leu Glu Leu 
65                  70                  75                  80  


Tyr Gln Ala Leu Leu Glu Gly Gln Glu Gly Ala Trp Glu Ala Gln Ala 
                85                  90                  95      


Leu Val Leu Lys Ile Gln Lys Leu Lys Glu Gln Met Arg Arg His Gln 
            100                 105                 110         


Glu Ser Leu Gly Gly Gly Ala 
        115                 


<210>  1500
<211>  2133
<212>  DNA
<213>  Homosapiens

<400>  1500
ctcagctagg gcctgccggt tcctagtgcg tgcccagcag tcctcaggtc accttcacta     60

ccgggccaag gaccccgtgg gaactcgcag ccttcgccac actcgttcct cgcgcatcca    120

tggaggggtg cctacagaga agacctgcgt ggcaaaaacc taaacgaaga gatgaggggc    180

atggagagga gtaggataag agaataaaga taacagtggg ggggagacgt tagtttcctt    240

tatatctttt gttactggcg gtagcagtga agttagaaac ggttttaaaa caaatttcag    300

acaggcattt tccaaaggca agcctggagc gcacggatct gtataaccgc ggaaggccct    360

gtttccggtc ccttgcgcct gcgctcttgc agccaagaag gcgggaggct ggagtagagg    420

gaagcctgca accggaagtg aaggcagatt tccctccttc gtcgctgttg ctgccgccat    480

acgcgctctc cctgtttagc tcttctgtta gaaatagtat ctttgttttc ctttgctgtt    540

cctcaatccc ctactcttca ccccttgttt tcacctattt tgcgagaacc catccagatc    600

ccccttccct tcttcccctg ccggcccagt tatggcagag aacgatgtgg acaatgagct    660

cttggactat gaagatgatg aggtggagac agcagctggg ggagatgggg ctgaggcccc    720

tgccaagaag gatgtcaagg gctcctatgt ctccatccac agctctggct ttcgtgactt    780

cctgctcaag ccagagttgc tccgggccat tgtcgactgt ggctttgagc atccgtcaga    840

agtccagcat gagtgcatcc ctcaggccat tctgggaatg gatgtcctgt gccaggccaa    900

gtcgggcatg ggaaagacag cagtgtttgt cttggccaca ctgcaacagc tggagccagt    960

tactgggcag gtgtctgtac tggtgatgtg tcacactcgg gagttggctt ttcagatcag   1020

caaggaatat gagcgcttct ctaaatacat gcccaatgtc aaggttgctg ttttttttgg   1080

tggtctgtct atcaagaagg atgaagaggt gctgaagaag aactgcccgc atatcgtcgt   1140

ggggactcca ggccgtatcc tagccctggc tcgaaataag agcctcaacc tcaaacacat   1200

taaacacttt attttggatg aatgtgataa gatgcttgaa cagctcgaca tgcgtcggga   1260

tgtccaggaa atttttcgca tgacccccca cgagaagcag gtcatgatgt tcagtgctac   1320

cttgagcaaa gagatccgtc cagtctgccg caagttcatg caagatccaa tggagatctt   1380

cgtggatgat gagacgaagt tgacgctgca tgggttgcag cagtactacg tgaaactgaa   1440

ggacaacgag aagaaccgga agctctttga ccttctggat gtccttgagt tcaaccaggt   1500

ggtgatcttt gtgaagtctg tgcagcggtg cattgccttg gcccagctac tagtggagca   1560

gaacttccca gccattgcca tccaccgtgg gatgccccag gaggagaggc tttctcggta   1620

tcagcagttt aaagattttc aacgacgaat tcttgtggct accaacctat ttggccgagg   1680

catggacatc gagcgggtga acattgcttt taattatgac atgcctgagg attctgacac   1740

ctacctgcat cgggtggcca gagcaggccg gtttggcacc aagggcttgg ctatcacatt   1800

tgtgtccgat gagaatgatg ccaagatcct caatgatgtg caggatcgct ttgaggtcaa   1860

tattagtgag ctgcctgatg agatagacat ctcctcctac attgaacaga cacggtagaa   1920

gactcgccca ttttggaatg tgaccgtctg tccttcagga gaggacacca gggtgggggt   1980

gaaggagaca ctactgcccc cacccctgac agcccccacc ccatggcttc catcttttgc   2040

atcaccacca ctcctgaacc cccatttctg atttgtcaga attttttttt aacaaaacta   2100

aaaatgaaac acatgtgtct gtggtatcta taa                                2133


<210>  1501
<211>  428
<212>  PRT
<213>  Homosapiens

<400>  1501

Met Ala Glu Asn Asp Val Asp Asn Glu Leu Leu Asp Tyr Glu Asp Asp 
1               5                   10                  15      


Glu Val Glu Thr Ala Ala Gly Gly Asp Gly Ala Glu Ala Pro Ala Lys 
            20                  25                  30          


Lys Asp Val Lys Gly Ser Tyr Val Ser Ile His Ser Ser Gly Phe Arg 
        35                  40                  45              


Asp Phe Leu Leu Lys Pro Glu Leu Leu Arg Ala Ile Val Asp Cys Gly 
    50                  55                  60                  


Phe Glu His Pro Ser Glu Val Gln His Glu Cys Ile Pro Gln Ala Ile 
65                  70                  75                  80  


Leu Gly Met Asp Val Leu Cys Gln Ala Lys Ser Gly Met Gly Lys Thr 
                85                  90                  95      


Ala Val Phe Val Leu Ala Thr Leu Gln Gln Leu Glu Pro Val Thr Gly 
            100                 105                 110         


Gln Val Ser Val Leu Val Met Cys His Thr Arg Glu Leu Ala Phe Gln 
        115                 120                 125             


Ile Ser Lys Glu Tyr Glu Arg Phe Ser Lys Tyr Met Pro Asn Val Lys 
    130                 135                 140                 


Val Ala Val Phe Phe Gly Gly Leu Ser Ile Lys Lys Asp Glu Glu Val 
145                 150                 155                 160 


Leu Lys Lys Asn Cys Pro His Ile Val Val Gly Thr Pro Gly Arg Ile 
                165                 170                 175     


Leu Ala Leu Ala Arg Asn Lys Ser Leu Asn Leu Lys His Ile Lys His 
            180                 185                 190         


Phe Ile Leu Asp Glu Cys Asp Lys Met Leu Glu Gln Leu Asp Met Arg 
        195                 200                 205             


Arg Asp Val Gln Glu Ile Phe Arg Met Thr Pro His Glu Lys Gln Val 
    210                 215                 220                 


Met Met Phe Ser Ala Thr Leu Ser Lys Glu Ile Arg Pro Val Cys Arg 
225                 230                 235                 240 


Lys Phe Met Gln Asp Pro Met Glu Ile Phe Val Asp Asp Glu Thr Lys 
                245                 250                 255     


Leu Thr Leu His Gly Leu Gln Gln Tyr Tyr Val Lys Leu Lys Asp Asn 
            260                 265                 270         


Glu Lys Asn Arg Lys Leu Phe Asp Leu Leu Asp Val Leu Glu Phe Asn 
        275                 280                 285             


Gln Val Val Ile Phe Val Lys Ser Val Gln Arg Cys Ile Ala Leu Ala 
    290                 295                 300                 


Gln Leu Leu Val Glu Gln Asn Phe Pro Ala Ile Ala Ile His Arg Gly 
305                 310                 315                 320 


Met Pro Gln Glu Glu Arg Leu Ser Arg Tyr Gln Gln Phe Lys Asp Phe 
                325                 330                 335     


Gln Arg Arg Ile Leu Val Ala Thr Asn Leu Phe Gly Arg Gly Met Asp 
            340                 345                 350         


Ile Glu Arg Val Asn Ile Ala Phe Asn Tyr Asp Met Pro Glu Asp Ser 
        355                 360                 365             


Asp Thr Tyr Leu His Arg Val Ala Arg Ala Gly Arg Phe Gly Thr Lys 
    370                 375                 380                 


Gly Leu Ala Ile Thr Phe Val Ser Asp Glu Asn Asp Ala Lys Ile Leu 
385                 390                 395                 400 


Asn Asp Val Gln Asp Arg Phe Glu Val Asn Ile Ser Glu Leu Pro Asp 
                405                 410                 415     


Glu Ile Asp Ile Ser Ser Tyr Ile Glu Gln Thr Arg 
            420                 425             


<210>  1502
<211>  2003
<212>  DNA
<213>  Homosapiens

<400>  1502
ctcagctagg gcctgccggt tcctagtgcg tgcccagcag tcctcaggtc accttcacta     60

ccgggccaag gaccccgtgg gaactcgcag ccttcgccac actcgttcct cgcgcatcca    120

tggaggggtg cctacagaga agacctgcgt ggcaaaaacc taaacgaaga gatgaggggc    180

atggagagga gtaggataag agaataaaga taacagtggg ggggagacgt tagtttcctt    240

tatatctttt gttactggcg gtagcagtga agttagaaac ggttttaaaa caaatttcag    300

acaggcattt tccaaaggca agcctggagc gcacggatct gtataaccgc ggaaggccct    360

gtttccggtc ccttgcgcct gcgctcttgc agccaagaag gcgggaggct ggagtagagg    420

gaagcctgca accggaagtg aaggcagatt tccctccttc gtcgctgttg ctgccgccat    480

acgcgctctc cctgtttagt tatggcagag aacgatgtgg acaatgagct cttggactat    540

gaagatgatg aggtggagac agcagctggg ggagatgggg ctgaggcccc tgccaagaag    600

gatgtcaagg gctcctatgt ctccatccac agctctggct ttcgtgactt cctgctcaag    660

ccagagttgc tccgggccat tgtcgactgt ggctttgagc atccgtcaga agtccagcat    720

gagtgcatcc ctcaggccat tctgggaatg gatgtcctgt gccaggccaa gtcgggcatg    780

ggaaagacag cagtgtttgt cttggccaca ctgcaacagc tggagccagt tactgggcag    840

gtgtctgtac tggtgatgtg tcacactcgg gagttggctt ttcagatcag caaggaatat    900

gagcgcttct ctaaatacat gcccaatgtc aaggttgctg ttttttttgg tggtctgtct    960

atcaagaagg atgaagaggt gctgaagaag aactgcccgc atatcgtcgt ggggactcca   1020

ggccgtatcc tagccctggc tcgaaataag agcctcaacc tcaaacacat taaacacttt   1080

attttggatg aatgtgataa gatgcttgaa cagctcgaca tgcgtcggga tgtccaggaa   1140

atttttcgca tgacccccca cgagaagcag gtcatgatgt tcagtgctac cttgagcaaa   1200

gagatccgtc cagtctgccg caagttcatg caagatccaa tggagatctt cgtggatgat   1260

gagacgaagt tgacgctgca tgggttgcag cagtactacg tgaaactgaa ggacaacgag   1320

aagaaccgga agctctttga ccttctggat gtccttgagt tcaaccaggt ggtgatcttt   1380

gtgaagtctg tgcagcggtg cattgccttg gcccagctac tagtggagca gaacttccca   1440

gccattgcca tccaccgtgg gatgccccag gaggagaggc tttctcggta tcagcagttt   1500

aaagattttc aacgacgaat tcttgtggct accaacctat ttggccgagg catggacatc   1560

gagcgggtga acattgcttt taattatgac atgcctgagg attctgacac ctacctgcat   1620

cgggtggcca gagcaggccg gtttggcacc aagggcttgg ctatcacatt tgtgtccgat   1680

gagaatgatg ccaagatcct caatgatgtg caggatcgct ttgaggtcaa tattagtgag   1740

ctgcctgatg agatagacat ctcctcctac attgaacaga cacggtagaa gactcgccca   1800

ttttggaatg tgaccgtctg tccttcagga gaggacacca gggtgggggt gaaggagaca   1860

ctactgcccc cacccctgac agcccccacc ccatggcttc catcttttgc atcaccacca   1920

ctcctgaacc cccatttctg atttgtcaga attttttttt aacaaaacta aaaatgaaac   1980

acatgtgtct gtggtatcta taa                                           2003


<210>  1503
<211>  428
<212>  PRT
<213>  Homosapiens

<400>  1503

Met Ala Glu Asn Asp Val Asp Asn Glu Leu Leu Asp Tyr Glu Asp Asp 
1               5                   10                  15      


Glu Val Glu Thr Ala Ala Gly Gly Asp Gly Ala Glu Ala Pro Ala Lys 
            20                  25                  30          


Lys Asp Val Lys Gly Ser Tyr Val Ser Ile His Ser Ser Gly Phe Arg 
        35                  40                  45              


Asp Phe Leu Leu Lys Pro Glu Leu Leu Arg Ala Ile Val Asp Cys Gly 
    50                  55                  60                  


Phe Glu His Pro Ser Glu Val Gln His Glu Cys Ile Pro Gln Ala Ile 
65                  70                  75                  80  


Leu Gly Met Asp Val Leu Cys Gln Ala Lys Ser Gly Met Gly Lys Thr 
                85                  90                  95      


Ala Val Phe Val Leu Ala Thr Leu Gln Gln Leu Glu Pro Val Thr Gly 
            100                 105                 110         


Gln Val Ser Val Leu Val Met Cys His Thr Arg Glu Leu Ala Phe Gln 
        115                 120                 125             


Ile Ser Lys Glu Tyr Glu Arg Phe Ser Lys Tyr Met Pro Asn Val Lys 
    130                 135                 140                 


Val Ala Val Phe Phe Gly Gly Leu Ser Ile Lys Lys Asp Glu Glu Val 
145                 150                 155                 160 


Leu Lys Lys Asn Cys Pro His Ile Val Val Gly Thr Pro Gly Arg Ile 
                165                 170                 175     


Leu Ala Leu Ala Arg Asn Lys Ser Leu Asn Leu Lys His Ile Lys His 
            180                 185                 190         


Phe Ile Leu Asp Glu Cys Asp Lys Met Leu Glu Gln Leu Asp Met Arg 
        195                 200                 205             


Arg Asp Val Gln Glu Ile Phe Arg Met Thr Pro His Glu Lys Gln Val 
    210                 215                 220                 


Met Met Phe Ser Ala Thr Leu Ser Lys Glu Ile Arg Pro Val Cys Arg 
225                 230                 235                 240 


Lys Phe Met Gln Asp Pro Met Glu Ile Phe Val Asp Asp Glu Thr Lys 
                245                 250                 255     


Leu Thr Leu His Gly Leu Gln Gln Tyr Tyr Val Lys Leu Lys Asp Asn 
            260                 265                 270         


Glu Lys Asn Arg Lys Leu Phe Asp Leu Leu Asp Val Leu Glu Phe Asn 
        275                 280                 285             


Gln Val Val Ile Phe Val Lys Ser Val Gln Arg Cys Ile Ala Leu Ala 
    290                 295                 300                 


Gln Leu Leu Val Glu Gln Asn Phe Pro Ala Ile Ala Ile His Arg Gly 
305                 310                 315                 320 


Met Pro Gln Glu Glu Arg Leu Ser Arg Tyr Gln Gln Phe Lys Asp Phe 
                325                 330                 335     


Gln Arg Arg Ile Leu Val Ala Thr Asn Leu Phe Gly Arg Gly Met Asp 
            340                 345                 350         


Ile Glu Arg Val Asn Ile Ala Phe Asn Tyr Asp Met Pro Glu Asp Ser 
        355                 360                 365             


Asp Thr Tyr Leu His Arg Val Ala Arg Ala Gly Arg Phe Gly Thr Lys 
    370                 375                 380                 


Gly Leu Ala Ile Thr Phe Val Ser Asp Glu Asn Asp Ala Lys Ile Leu 
385                 390                 395                 400 


Asn Asp Val Gln Asp Arg Phe Glu Val Asn Ile Ser Glu Leu Pro Asp 
                405                 410                 415     


Glu Ile Asp Ile Ser Ser Tyr Ile Glu Gln Thr Arg 
            420                 425             


<210>  1504
<211>  1594
<212>  DNA
<213>  Homosapiens

<400>  1504
ggctaacctg ttgtaagccc gcagctttgg gcctggtctc tgctgctccc aggcggcccc     60

tttgggtact gcctgagcaa gaagtgctgg agaggaggac cagtcatcaa taggaggatg    120

agattgggag agacactcgg tgcaggaggc tgagtgagca ggggagcact aagacccagg    180

ggtagtggag gactgcagca acgagctgga ggaggagaag taagcggtgg ggggtgggag    240

ccatctggta ctttgacagc attcaaaaca gcatcggcca taacaacaga aatggccagt    300

cagtcccaag gtatccagca gcttctgcaa gctgagaagc gggcagctga gaaggtggca    360

gatgccagaa agaggaaggc ccggcgactg aagcaggcaa aggaggaggc acagatggag    420

gtggagcaat accgcagaga gcgagagcac gaattccaga gcaagcagca ggcggccatg    480

ggctcccagg ggaacctgtc tgctgaggtg gagcaggcta caaggcgcca ggtgcagggc    540

atgcagagct cccagcagag aaaccgagag cgtgtcctgg cccagcttct tggcatggtc    600

tgcgacgtca ggccccaggt ccaccccaac taccggattt ctgcctaggg ccaccgtagg    660

gcctgactcc ttctgccagt tccctccctc aaagaaatcc tccaatcaaa atcacctccc    720

accataatcc ctgtcttctt tccatcccct agaaatcctg ggaggcagga tccaataatt    780

ttcctgtgac acttataaat atcctgctca catctgaatc tccttgttgt tctttaaccc    840

tcactgggac tttgtaaact tccaagtcat tctcacctaa accctctgtg aaatttgtaa    900

tatggggaag taggaatgtg gaaaacatcc tgacttcagt gtctggccga tgtgggtccc    960

tctcttgacc ctgtcacttg ctggctgtga aaccaggaca agctacttaa cttggtagcc   1020

tcgatgtcct cctctgtgaa actgggatga taataatgcc taccttgtga gggttgcttc   1080

aatgattagg aatcattctg taaagtctag cacagttcct tgcatgttgt agcagtgatt   1140

cagtaagtag caaccctgtg atactattac caccacctgc tcactggtca aaacctacac   1200

agctgtttcc tcacgtccat cactggctct ctaattccac ttgttcattc tgtgacccta   1260

gttattttct gaaaaattgg ttcttctctt ttcccagaga ccttctgatc tccaaaaaga   1320

ggagatgact acatttagcc cctctcttat aattccaggt agataactgc attttgtagc   1380

ctctctttgt ttttcttttg ctgatctttg tctttattag attttcctcc tttcctattt   1440

ccccaaagac ttatcagatg ctcattgctt tctaagatct aaaatgatac tgtgttccct   1500

catatgcatg cccttccttt ctatatcctt gacaccttac tttcccattg taacaataaa   1560

aaaagtatca ataaaataat tattggcaaa taaa                               1594


<210>  1505
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  1505

Met Ala Ser Gln Ser Gln Gly Ile Gln Gln Leu Leu Gln Ala Glu Lys 
1               5                   10                  15      


Arg Ala Ala Glu Lys Val Ala Asp Ala Arg Lys Arg Lys Ala Arg Arg 
            20                  25                  30          


Leu Lys Gln Ala Lys Glu Glu Ala Gln Met Glu Val Glu Gln Tyr Arg 
        35                  40                  45              


Arg Glu Arg Glu His Glu Phe Gln Ser Lys Gln Gln Ala Ala Met Gly 
    50                  55                  60                  


Ser Gln Gly Asn Leu Ser Ala Glu Val Glu Gln Ala Thr Arg Arg Gln 
65                  70                  75                  80  


Val Gln Gly Met Gln Ser Ser Gln Gln Arg Asn Arg Glu Arg Val Leu 
                85                  90                  95      


Ala Gln Leu Leu Gly Met Val Cys Asp Val Arg Pro Gln Val His Pro 
            100                 105                 110         


Asn Tyr Arg Ile Ser Ala 
        115             


<210>  1506
<211>  1440
<212>  DNA
<213>  Homosapiens

<400>  1506
ggctaacctg ttgtaagccc gcagctttgg gcctggtctc tgctgctccc aggcggcccc     60

tttgggtact gcctgagcaa gaagtgctgg agaggaggac cagtcatcaa taggaggatg    120

agattgggag agacactcgg tgcaggaggc tgagtgagca ggggagcact aagacccagg    180

ggtagtggag gactgcagca acgagctgga ggaggagaag gaaggcccgg cgactgaagc    240

aggcaaagga ggaggcacag atggaggtgg agcaataccg cagagagcga gagcacgaat    300

tccagagcaa gcagcaggcg gccatgggct cccaggggaa cctgtctgct gaggtggagc    360

aggctacaag gcgccaggtg cagggcatgc agagctccca gcagagaaac cgagagcgtg    420

tcctggccca gcttcttggc atggtctgcg acgtcaggcc ccaggtccac cccaactacc    480

ggatttctgc ctagggccac cgtagggcct gactccttct gccagttccc tccctcaaag    540

aaatcctcca atcaaaatca cctcccacca taatccctgt cttctttcca tcccctagaa    600

atcctgggag gcaggatcca ataattttcc tgtgacactt ataaatatcc tgctcacatc    660

tgaatctcct tgttgttctt taaccctcac tgggactttg taaacttcca agtcattctc    720

acctaaaccc tctgtgaaat ttgtaatatg gggaagtagg aatgtggaaa acatcctgac    780

ttcagtgtct ggccgatgtg ggtccctctc ttgaccctgt cacttgctgg ctgtgaaacc    840

aggacaagct acttaacttg gtagcctcga tgtcctcctc tgtgaaactg ggatgataat    900

aatgcctacc ttgtgagggt tgcttcaatg attaggaatc attctgtaaa gtctagcaca    960

gttccttgca tgttgtagca gtgattcagt aagtagcaac cctgtgatac tattaccacc   1020

acctgctcac tggtcaaaac ctacacagct gtttcctcac gtccatcact ggctctctaa   1080

ttccacttgt tcattctgtg accctagtta ttttctgaaa aattggttct tctcttttcc   1140

cagagacctt ctgatctcca aaaagaggag atgactacat ttagcccctc tcttataatt   1200

ccaggtagat aactgcattt tgtagcctct ctttgttttt cttttgctga tctttgtctt   1260

tattagattt tcctcctttc ctatttcccc aaagacttat cagatgctca ttgctttcta   1320

agatctaaaa tgatactgtg ttccctcata tgcatgccct tcctttctat atccttgaca   1380

ccttactttc ccattgtaac aataaaaaaa gtatcaataa aataattatt ggcaaataaa   1440


<210>  1507
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  1507

Met Glu Val Glu Gln Tyr Arg Arg Glu Arg Glu His Glu Phe Gln Ser 
1               5                   10                  15      


Lys Gln Gln Ala Ala Met Gly Ser Gln Gly Asn Leu Ser Ala Glu Val 
            20                  25                  30          


Glu Gln Ala Thr Arg Arg Gln Val Gln Gly Met Gln Ser Ser Gln Gln 
        35                  40                  45              


Arg Asn Arg Glu Arg Val Leu Ala Gln Leu Leu Gly Met Val Cys Asp 
    50                  55                  60                  


Val Arg Pro Gln Val His Pro Asn Tyr Arg Ile Ser Ala 
65                  70                  75          


<210>  1508
<211>  1491
<212>  DNA
<213>  Homosapiens

<400>  1508
ggagtgtctc cgcccttccc gcctcccgtc tccgagcttc ttaaacacag gccttgggcc     60

tacggctctg ggggtacttg ggggggcggg ggcaggtctg atgagtaacc cctcccccca    120

ggttccagag gaagaagcct ccacatctgt ctgccggccc aagagttcca tggcctccac    180

ttcccgccgc caacgccgag aacgtcgctt tcgtcgttac ttgtctgcag gacggctggt    240

ccgggcccag gccctcctcc agcgacaccc aggcctcgat gtagatgctg ggcagccccc    300

accactgcac cgggcctgtg cccgccacga tgcccctgcc ctgtgcctgc tgcttcggct    360

cggggctgac cctgcccacc aggaccgcca tggggacacg gcactgcatg ctgctgcccg    420

ccagggccca gatgcctaca ccgatttctt cctcccgctg ctaagccgct gtccctccgc    480

catgggaata aagaataagg atggggagac ccctggccaa attttgggct ggggaccccc    540

ctgggattct gctgaagagg aggaagaaga tgatgcctcc aaggagcggg aatggagaca    600

gaagctccag ggtgagctgg aggacgagtg gcaggaagtc atggggaggt ttgaaggtga    660

tgcctcccat gaaacccagg aacctgagtc cttctcagcc tggtcagatc gcctggcccg    720

ggaacatgcc cagaagtgcc agcagcagca gcgagaagca gagggatcct gtcgaccccc    780

acgtgctgag ggctccagcc agagctggcg acagcaggag gaggagcagc ggctcttcag    840

ggagcgagcc cgggccaagg aggaagagct gcgtgagagc cgagccagga gggcgcagga    900

ggctctaggg gaccgagaac ccaagccaac cagggccggg cccagggaag agcaccccag    960

aggagcgggg aggggcagcc tctggcgatt tggtgatgtg ccctggccct gccctggggg   1020

aggggaccca gaggccatgg ctgcagccct ggtggccagg ggcccccctt tggaggaaca   1080

gggggctctg aggaggtact tgagggtcca gcaggtccgc tggcaccctg accgcttcct   1140

gcagcgattc cgaagccaga ttgagacctg ggagctgggc cgtgtgatgg gagcagtgac   1200

agccctttct caggccctga atcgccatgc agaggccctc aagtgaccct agggaagaag   1260

caagaaactt cggggctgca gcctcaggat gaggcagaag gaagggtaag ggaaaggatg   1320

gggaccacaa ggaagagcca ggtgctgctc agcagaggat atgggtggga gcgaaagttg   1380

taacaagtgg gggtgggggg tgcgggccgc caccactgct ccttgactct gccgtttcct   1440

aataagacct ggttccacat ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa a            1491


<210>  1509
<211>  381
<212>  PRT
<213>  Homosapiens

<400>  1509

Met Ser Asn Pro Ser Pro Gln Val Pro Glu Glu Glu Ala Ser Thr Ser 
1               5                   10                  15      


Val Cys Arg Pro Lys Ser Ser Met Ala Ser Thr Ser Arg Arg Gln Arg 
            20                  25                  30          


Arg Glu Arg Arg Phe Arg Arg Tyr Leu Ser Ala Gly Arg Leu Val Arg 
        35                  40                  45              


Ala Gln Ala Leu Leu Gln Arg His Pro Gly Leu Asp Val Asp Ala Gly 
    50                  55                  60                  


Gln Pro Pro Pro Leu His Arg Ala Cys Ala Arg His Asp Ala Pro Ala 
65                  70                  75                  80  


Leu Cys Leu Leu Leu Arg Leu Gly Ala Asp Pro Ala His Gln Asp Arg 
                85                  90                  95      


His Gly Asp Thr Ala Leu His Ala Ala Ala Arg Gln Gly Pro Asp Ala 
            100                 105                 110         


Tyr Thr Asp Phe Phe Leu Pro Leu Leu Ser Arg Cys Pro Ser Ala Met 
        115                 120                 125             


Gly Ile Lys Asn Lys Asp Gly Glu Thr Pro Gly Gln Ile Leu Gly Trp 
    130                 135                 140                 


Gly Pro Pro Trp Asp Ser Ala Glu Glu Glu Glu Glu Asp Asp Ala Ser 
145                 150                 155                 160 


Lys Glu Arg Glu Trp Arg Gln Lys Leu Gln Gly Glu Leu Glu Asp Glu 
                165                 170                 175     


Trp Gln Glu Val Met Gly Arg Phe Glu Gly Asp Ala Ser His Glu Thr 
            180                 185                 190         


Gln Glu Pro Glu Ser Phe Ser Ala Trp Ser Asp Arg Leu Ala Arg Glu 
        195                 200                 205             


His Ala Gln Lys Cys Gln Gln Gln Gln Arg Glu Ala Glu Gly Ser Cys 
    210                 215                 220                 


Arg Pro Pro Arg Ala Glu Gly Ser Ser Gln Ser Trp Arg Gln Gln Glu 
225                 230                 235                 240 


Glu Glu Gln Arg Leu Phe Arg Glu Arg Ala Arg Ala Lys Glu Glu Glu 
                245                 250                 255     


Leu Arg Glu Ser Arg Ala Arg Arg Ala Gln Glu Ala Leu Gly Asp Arg 
            260                 265                 270         


Glu Pro Lys Pro Thr Arg Ala Gly Pro Arg Glu Glu His Pro Arg Gly 
        275                 280                 285             


Ala Gly Arg Gly Ser Leu Trp Arg Phe Gly Asp Val Pro Trp Pro Cys 
    290                 295                 300                 


Pro Gly Gly Gly Asp Pro Glu Ala Met Ala Ala Ala Leu Val Ala Arg 
305                 310                 315                 320 


Gly Pro Pro Leu Glu Glu Gln Gly Ala Leu Arg Arg Tyr Leu Arg Val 
                325                 330                 335     


Gln Gln Val Arg Trp His Pro Asp Arg Phe Leu Gln Arg Phe Arg Ser 
            340                 345                 350         


Gln Ile Glu Thr Trp Glu Leu Gly Arg Val Met Gly Ala Val Thr Ala 
        355                 360                 365             


Leu Ser Gln Ala Leu Asn Arg His Ala Glu Ala Leu Lys 
    370                 375                 380     


<210>  1510
<211>  1386
<212>  DNA
<213>  Homosapiens

<400>  1510
gccccatctc cttgggctgc ccgtgcttcg tgctttggac taccgcccag cagtgtcctg     60

ccctctgcct gggcctcggt ccctcctgca cctgctgcct ggatccccgg cctgcctggg    120

cctgggcctt ggttctcccc atgacaccac ctgaacgtct cttcctccca agggtgtgtg    180

gcaccaccct acacctcctc cttctggggc tgctgctggt tctgctgcct ggggcccagg    240

ggctccctgg tgttggcctc acaccttcag ctgcccagac tgcccgtcag caccccaaga    300

tgcatcttgc ccacagcacc ctcaaacctg ctgctcacct cattggagac cccagcaagc    360

agaactcact gctctggaga gcaaacacgg accgtgcctt cctccaggat ggtttctcct    420

tgagcaacaa ttctctcctg gtccccacca gtggcatcta cttcgtctac tcccaggtgg    480

tcttctctgg gaaagcctac tctcccaagg ccacctcctc cccactctac ctggcccatg    540

aggtccagct cttctcctcc cagtacccct tccatgtgcc tctcctcagc tcccagaaga    600

tggtgtatcc agggctgcag gaaccctggc tgcactcgat gtaccacggg gctgcgttcc    660

agctcaccca gggagaccag ctatccaccc acacagatgg catcccccac ctagtcctca    720

gccctagtac tgtcttcttt ggagccttcg ctctgtagaa cttggaaaaa tccagaaaga    780

aaaaataatt gatttcaaga ccttctcccc attctgcctc cattctgacc atttcagggg    840

tcgtcaccac ctctcctttg gccattccaa cagctcaagt cttccctgat caagtcaccg    900

gagctttcaa agaaggaatt ctaggcatcc caggggacca cacctccctg aaccatccct    960

gatgtctgtc tggctgagga tttcaagcct gcctaggaat tcccagccca aagctgttgg   1020

tctgtcccac cagctaggtg gggcctagat ccacacacag aggaagagca ggcacatgga   1080

ggagcttggg ggatgactag aggcagggag gggactattt atgaaggcaa aaaaattaaa   1140

ttatttattt atggaggatg gagagagggg aataatagaa gaacatccaa ggagaaacag   1200

agacaggccc aagagatgaa gagtgagagg gcatgcgcac aaggctgacc aagagagaaa   1260

gaagtaggca tgagggatca cagggcccca gaaggcaggg aaaggctctg aaagccagct   1320

gccgaccaga gccccacacg gaggcatctg caccctcgat gaagcccaat aaacctcttt   1380

tctctg                                                              1386


<210>  1511
<211>  205
<212>  PRT
<213>  Homosapiens

<400>  1511

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  1512
<211>  1669
<212>  DNA
<213>  Homosapiens

<400>  1512
ctccctcagc aaggacagca gaggaccagc taagagggag agaagcaact acagaccccc     60

cctgaaaaca accctcagac gccacatccc ctgacaagct gccaggcagg ttctcttcct    120

ctcacatact gacccacggc tccaccctct ctcccctgga aaggacacca tgagcactga    180

aagcatgatc cgggacgtgg agctggccga ggaggcgctc cccaagaaga caggggggcc    240

ccagggctcc aggcggtgct tgttcctcag cctcttctcc ttcctgatcg tggcaggcgc    300

caccacgctc ttctgcctgc tgcactttgg agtgatcggc ccccagaggg aagagttccc    360

cagggacctc tctctaatca gccctctggc ccaggcagtc agatcatctt ctcgaacccc    420

gagtgacaag cctgtagccc atgttgtagc aaaccctcaa gctgaggggc agctccagtg    480

gctgaaccgc cgggccaatg ccctcctggc caatggcgtg gagctgagag ataaccagct    540

ggtggtgcca tcagagggcc tgtacctcat ctactcccag gtcctcttca agggccaagg    600

ctgcccctcc acccatgtgc tcctcaccca caccatcagc cgcatcgccg tctcctacca    660

gaccaaggtc aacctcctct ctgccatcaa gagcccctgc cagagggaga ccccagaggg    720

ggctgaggcc aagccctggt atgagcccat ctatctggga ggggtcttcc agctggagaa    780

gggtgaccga ctcagcgctg agatcaatcg gcccgactat ctcgactttg ccgagtctgg    840

gcaggtctac tttgggatca ttgccctgtg aggaggacga acatccaacc ttcccaaacg    900

cctcccctgc cccaatccct ttattacccc ctccttcaga caccctcaac ctcttctggc    960

tcaaaaagag aattgggggc ttagggtcgg aacccaagct tagaacttta agcaacaaga   1020

ccaccacttc gaaacctggg attcaggaat gtgtggcctg cacagtgaag tgctggcaac   1080

cactaagaat tcaaactggg gcctccagaa ctcactgggg cctacagctt tgatccctga   1140

catctggaat ctggagacca gggagccttt ggttctggcc agaatgctgc aggacttgag   1200

aagacctcac ctagaaattg acacaagtgg accttaggcc ttcctctctc cagatgtttc   1260

cagacttcct tgagacacgg agcccagccc tccccatgga gccagctccc tctatttatg   1320

tttgcacttg tgattattta ttatttattt attatttatt tatttacaga tgaatgtatt   1380

tatttgggag accggggtat cctgggggac ccaatgtagg agctgccttg gctcagacat   1440

gttttccgtg aaaacggagc tgaacaatag gctgttccca tgtagccccc tggcctctgt   1500

gccttctttt gattatgttt tttaaaatat ttatctgatt aagttgtcta aacaatgctg   1560

atttggtgac caactgtcac tcattgctga gcctctgctc cccaggggag ttgtgtctgt   1620

aatcgcccta ctattcagtg gcgagaaata aagtttgctt agaaaagaa               1669


<210>  1513
<211>  233
<212>  PRT
<213>  Homosapiens

<400>  1513

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  1514
<211>  894
<212>  DNA
<213>  Homosapiens

<400>  1514
cagtctcaat gggggcactg gggctggagg gcaggggtgg gaggctccag gggaggggtt     60

ccctcctgct agctgtggca ggagccactt ctctggtgac cttgttgctg gcggtgccta    120

tcactgtcct ggctgtgctg gccttagtgc cccaggatca gggaggactg gtaacggaga    180

cggccgaccc cggggcacag gcccagcaag gactggggtt tcagaagctg ccagaggagg    240

agccagaaac agatctcagc cccgggctcc cagctgccca cctcataggc gctccgctga    300

aggggcaggg gctaggctgg gagacgacga aggaacaggc gtttctgacg agcgggacgc    360

agttctcgga cgccgagggg ctggcgctcc cgcaggacgg cctctattac ctctactgtc    420

tcgtcggcta ccggggccgg gcgccccctg gcggcgggga cccccagggc cgctcggtca    480

cgctgcgcag ctctctgtac cgggcggggg gcgcctacgg gccgggcact cccgagctgc    540

tgctcgaggg cgccgagacg gtgactccag tgctggaccc ggccaggaga caagggtacg    600

ggcctctctg gtacacgagc gtggggttcg gcggcctggt gcagctccgg aggggcgaga    660

gggtgtacgt caacatcagt caccccgata tggtggactt cgcgagaggg aagaccttct    720

ttggggccgt gatggtgggg tgagggaata tgagtgcgtg gtgcgagtgc gtgaatattg    780

ggggcccgga cgcccaggac cccatggcag tgggaaaaat gtaggagact gtttggaaat    840

tgattttgaa cctgatgaaa ataaagaatg gaaagcttca gtgctgccga taaa          894


<210>  1515
<211>  244
<212>  PRT
<213>  Homosapiens

<400>  1515

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
    50                  55                  60                  


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
65                  70                  75                  80  


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                85                  90                  95      


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            100                 105                 110         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        115                 120                 125             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    130                 135                 140                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
145                 150                 155                 160 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                165                 170                 175     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            180                 185                 190         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        195                 200                 205             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    210                 215                 220                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
225                 230                 235                 240 


Val Met Val Gly 
                


<210>  1516
<211>  848
<212>  DNA
<213>  Homosapiens

<400>  1516
cagtctcaat gggggcactg gggctggagg gcaggggtgg gaggctccag gggaggggtt     60

ccctcctgct agctgtggca ggagccactt ctctggtgac cttgttgctg gcggtgccta    120

tcactgtcct ggctgtgctg gccttagtgc cccaggatca gggaggactg ggtttcagaa    180

gctgccagag gaggagccag aaacagatct cagccccggg ctcccagctg cccacctcat    240

aggcgctccg ctgaaggggc aggggctagg ctgggagacg acgaaggaac aggcgtttct    300

gacgagcggg acgcagttct cggacgccga ggggctggcg ctcccgcagg acggcctcta    360

ttacctctac tgtctcgtcg gctaccgggg ccgggcgccc cctggcggcg gggaccccca    420

gggccgctcg gtcacgctgc gcagctctct gtaccgggcg gggggcgcct acgggccggg    480

cactcccgag ctgctgctcg agggcgccga gacggtgact ccagtgctgg acccggccag    540

gagacaaggg tacgggcctc tctggtacac gagcgtgggg ttcggcggcc tggtgcagct    600

ccggaggggc gagagggtgt acgtcaacat cagtcacccc gatatggtgg acttcgcgag    660

agggaagacc ttctttgggg ccgtgatggt ggggtgaggg aatatgagtg cgtggtgcga    720

gtgcgtgaat attgggggcc cggacgccca ggaccccatg gcagtgggaa aaatgtagga    780

gactgtttgg aaattgattt tgaacctgat gaaaataaag aatggaaagc ttcagtgctg    840

ccgataaa                                                             848


<210>  1517
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  1517

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Gly Phe Arg Ser Cys Gln Arg Arg Ser Gln 
    50                  55                  60                  


Lys Gln Ile Ser Ala Pro Gly Ser Gln Leu Pro Thr Ser 
65                  70                  75          


<210>  1518
<211>  765
<212>  DNA
<213>  Homosapiens

<400>  1518
aggctggggg agaagttaaa gccagaggag gggcaggaat gtctgaggtg gcaacacttc     60

tcttcagcca gacagcactg gccagtttgg agtctgtcca tcctgcaggc cacaagctct    120

ggatgaggaa cttgaggcaa gtcaccagcc cctgatcatt tcgcctaaaa gagcaaggac    180

tagagttcct gacctccagg ccagtccctg atccctgacc taatgttatc gcggaatgat    240

gatatatgta tctacggggg cctggggctg ggcgggctcc tgcttctggc agtggtcctt    300

ctgtccgcct gcctgtgttg gctgcatcga agagtaaaga ggctggagag gagctggccc    360

agggctcctc agagcaggaa ctccactatg catctctgca gaggctgcca gtgcccagca    420

gtgagggacc tgacctcagg ggcagagaca agagaggcac caaggaggat ccaagagctg    480

actatgcctg cattgctgag aacaaaccca cctgagcacc ccagacacct tcctcaaccc    540

aggcgggtgg acagggtccc cctgtggtcc agccagtaaa aaccatggtc cccccacttc    600

tgtgtctcag tcctctcagt ccatctcgag cctccgttca aattgatcat catcaaaact    660

tatgtggctt tttgaccttt gaatagggaa ttttttaaat tttttaaaaa ttaaaataaa    720

aaaaacacat ggctcaccct tccacccaaa aaaaaaaaaa aaaaa                    765


<210>  1519
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  1519

Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Val Lys Arg Leu Glu Arg Ser Trp Pro Arg Ala 
        35                  40                  45              


Pro Gln Ser Arg Asn Ser Thr Met His Leu Cys Arg Gly Cys Gln Cys 
    50                  55                  60                  


Pro Ala Val Arg Asp Leu Thr Ser Gly Ala Glu Thr Arg Glu Ala Pro 
65                  70                  75                  80  


Arg Arg Ile Gln Glu Leu Thr Met Pro Ala Leu Leu Arg Thr Asn Pro 
                85                  90                  95      


Pro Glu His Pro Arg His Leu Pro Gln Pro Arg Arg Val Asp Arg Val 
            100                 105                 110         


Pro Leu Trp Ser Ser Gln 
        115             


<210>  1520
<211>  619
<212>  DNA
<213>  Homosapiens

<400>  1520
cacccaccca ggcccaggct ccttcccctc catcatcccc ttaccagcac ctagaaccat     60

ccagggctga aaagtcccct ccaaaccacg tgatgaggaa cttgaggcaa gtcaccagcc    120

cctgatcatt tcgcctaaaa gagcaaggac tagagttcct gacctccagg ccagtccctg    180

atccctgacc taatgttatc gcggaatgat gcccagggct cctcagagca ggaactccac    240

tatgcatctc tgcagaggct gccagtgccc agcagtgagg gacctgacct caggggcaga    300

gacaagagag gcaccaagga ggatccaaga gctgactatg cctgcattgc tgagaacaaa    360

cccacctgag caccccagac accttcctca acccaggcgg gtggacaggg tccccctgtg    420

gtccagccag taaaaaccat ggtcccccca cttctgtgtc tcagtcctct cagtccatct    480

cgagcctccg ttcaaattga tcatcatcaa aacttatgtg gctttttgac ctttgaatag    540

ggaatttttt aaatttttta aaaattaaaa taaaaaaaac acatggctca cccttccacc    600

caaaaaaaaa aaaaaaaaa                                                 619


<210>  1521
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  1521

Met Met Pro Arg Ala Pro Gln Ser Arg Asn Ser Thr Met His Leu Cys 
1               5                   10                  15      


Arg Gly Cys Gln Cys Pro Ala Val Arg Asp Leu Thr Ser Gly Ala Glu 
            20                  25                  30          


Thr Arg Glu Ala Pro Arg Arg Ile Gln Glu Leu Thr Met Pro Ala Leu 
        35                  40                  45              


Leu Arg Thr Asn Pro Pro Glu His Pro Arg His Leu Pro Gln Pro Arg 
    50                  55                  60                  


Arg Val Asp Arg Val Pro Leu Trp Ser Ser Gln 
65                  70                  75  


<210>  1522
<211>  628
<212>  DNA
<213>  Homosapiens

<400>  1522
aggctggggg agaagttaaa gccagaggag gggcaggaat gtctgaggtg gcaacacttc     60

tcttcagcca gacagcactg gccagtttgg agtctgtcca tcctgcaggc cacaagctct    120

ggatgaggaa cttgaggcaa gtcaccagcc cctgatcatt tcgcctaaaa gagcaaggac    180

tagagttcct gacctccagg ccagtccctg atccctgacc taatgttatc gcggaatgat    240

gtaaagaggc tggagaggag ctggaggctg ccagtgccca gcagtgaggg acctgacctc    300

aggggcagag acaagagagg caccaaggag gatccaagag ctgactatgc ctgcattgct    360

gagaacaaac ccacctgagc accccagaca ccttcctcaa cccaggcggg tggacagggt    420

ccccctgtgg tccagccagt aaaaaccatg gtccccccac ttctgtgtct cagtcctctc    480

agtccatctc gagcctccgt tcaaattgat catcatcaaa acttatgtgg ctttttgacc    540

tttgaatagg gaatttttta aattttttaa aaattaaaat aaaaaaaaca catggctcac    600

ccttccaccc aaaaaaaaaa aaaaaaaa                                       628


<210>  1523
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  1523

Met Leu Ser Arg Asn Asp Val Lys Arg Leu Glu Arg Ser Trp Arg Leu 
1               5                   10                  15      


Pro Val Pro Ser Ser Glu Gly Pro Asp Leu Arg Gly Arg Asp Lys Arg 
            20                  25                  30          


Gly Thr Lys Glu Asp Pro Arg Ala Asp Tyr Ala Cys Ile Ala Glu Asn 
        35                  40                  45              


Lys Pro Thr 
    50      


<210>  1524
<211>  650
<212>  DNA
<213>  Homosapiens

<400>  1524
aggctggggg agaagttaaa gccagaggag gggcaggaat gtctgaggtg gcaacacttc     60

tcttcagcca gacagcactg gccagtttgg agtctgtcca tcctgcaggc cacaagctct    120

ggatgaggaa cttgaggcaa gtcaccagcc cctgatcatt tcgcctaaaa gagcaaggac    180

tagagttcct gacctccagg ccagtccctg atccctgacc taatgttatc gcggaatgat    240

ggcccagggc tcctcagagc aggaactcca ctatgcatct ctgcagaggc tgccagtgcc    300

cagcagtgag ggacctgacc tcaggggcag agacaagaga ggcaccaagg aggatccaag    360

agctgactat gcctgcattg ctgagaacaa acccacctga gcaccccaga caccttcctc    420

aacccaggcg ggtggacagg gtccccctgt ggtccagcca gtaaaaacca tggtcccccc    480

acttctgtgt ctcagtcctc tcagtccatc tcgagcctcc gttcaaattg atcatcatca    540

aaacttatgt ggctttttga cctttgaata gggaattttt taaatttttt aaaaattaaa    600

ataaaaaaaa cacatggctc acccttccac ccaaaaaaaa aaaaaaaaaa               650


<210>  1525
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  1525

Met His Leu Cys Arg Gly Cys Gln Cys Pro Ala Val Arg Asp Leu Thr 
1               5                   10                  15      


Ser Gly Ala Glu Thr Arg Glu Ala Pro Arg Arg Ile Gln Glu Leu Thr 
            20                  25                  30          


Met Pro Ala Leu Leu Arg Thr Asn Pro Pro Glu His Pro Arg His Leu 
        35                  40                  45              


Pro Gln Pro Arg Arg Val Asp Arg Val Pro Leu Trp Ser Ser Gln 
    50                  55                  60              


<210>  1526
<211>  605
<212>  DNA
<213>  Homosapiens

<400>  1526
aggctggggg agaagttaaa gccagaggag gggcaggaat gtctgaggtg gcaacacttc     60

tcttcagcca gacagcactg gccagtttgg agtctgtcca tcctgcaggc cacaagctct    120

ggatgaggaa cttgaggcaa gtcaccagcc cctgatcatt tcgcctaaaa gagcaaggac    180

tagagttcct gacctccagg ccagtccctg atccctgacc taatgttatc gcggaatgat    240

gaggctgcca gtgcccagca gtgagggacc tgacctcagg ggcagagaca agagaggcac    300

caaggaggat ccaagagctg actatgcctg cattgctgag aacaaaccca cctgagcacc    360

ccagacacct tcctcaaccc aggcgggtgg acagggtccc cctgtggtcc agccagtaaa    420

aaccatggtc cccccacttc tgtgtctcag tcctctcagt ccatctcgag cctccgttca    480

aattgatcat catcaaaact tatgtggctt tttgaccttt gaatagggaa ttttttaaat    540

tttttaaaaa ttaaaataaa aaaaacacat ggctcaccct tccacccaaa aaaaaaaaaa    600

aaaaa                                                                605


<210>  1527
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  1527

Met Met Arg Leu Pro Val Pro Ser Ser Glu Gly Pro Asp Leu Arg Gly 
1               5                   10                  15      


Arg Asp Lys Arg Gly Thr Lys Glu Asp Pro Arg Ala Asp Tyr Ala Cys 
            20                  25                  30          


Ile Ala Glu Asn Lys Pro Thr 
        35                  


<210>  1528
<211>  1061
<212>  DNA
<213>  Homosapiens

<400>  1528
ccacaagctg gccccttggc ctcctagaga ccctgacatc tcctccagca gcatctgtcc     60

tctctcctca gggaggcaag catttgatgc tcgaggtccc tggcagttgt ggtccttggc    120

aagtgatgtg tgagtcccgt gtgtcatagg aagctcccca tccccatctg gtgaccaaag    180

gcctggctac aagtagtgag tccttcctcc tccacccaga cctcactgct cagatcccct    240

tcgccaactg ggacatcttc cgacatggcc tggatgctgt tgctcatctt gatcatggtc    300

catccaggat cctgtgctct ctgggtgtcc cagccccctg agattcgtac cctggaagga    360

tcctctgcct tcctgccctg ctccttcaat gccagccaag ggagactggc cattggctcc    420

gtcacgtggt tccgagatga ggtggttcca gggaaggagg tgaggaatgg aaccccagag    480

ttcaggggcc gcctggcccc acttgcttct tcccgtttcc tccatgacca ccaggctgag    540

ctgcacatcc gggacgtgcg aggccatgac gccagcatct acgtgtgcag agtggaggtg    600

ctgggccttg gtgtcgggac agggaatggg actcggctgg tggtggagaa agaacatcct    660

cagctagggg ctggtacagt cctcctcctt cgggctggat tctatgctgt cagctttctc    720

tctgtggccg tgggcagcac cgtctattac cagggcaaat gtctgacctg gaaaggtcca    780

agaaggcagc tgccggctgt ggtcccagcg cccctcccac caccatgtgg gagctcagca    840

catctgcttc ccccagtccc aggaggctga gcctgattgt cctgagaaat gggaaggatc    900

agatatgact cctccttggc aactgccctt tcctgccagg cccacacata ccctcttctg    960

gctgttaggg gagcttgggt ccctgaacac tgtcattcac ccaataaatt actatttgac   1020

cccagagtgg gtggaagggt gaaaaaaaaa aaaaaaaaaa a                       1061


<210>  1529
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  1529

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu 
                165                 170                 175     


Pro Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala 
            180                 185                 190         


His Leu Leu Pro Pro Val Pro Gly Gly 
        195                 200     


<210>  1530
<211>  639
<212>  DNA
<213>  Homosapiens

<400>  1530
gagagaagga gagcctgcag acagaggcct ccagcttggt ctgtctcccc acctctacca     60

gcatctgctg agctatgagc caaaccaggg atttacaggg aggaaaagct ttcggactgc    120

tgaaggccca gcaggaagag aggctggatg agatcaacaa gcaattccta gacgatccca    180

aatatagcag tgatgaggat ctgccctcca aactggaagg cttcaaagag aaatacatgg    240

agtttgacct taatggaaat ggcgatattg atatcatgtc cctgaaacga atgctggaga    300

aacttggagt ccccaagact cacctagagc taaagaaatt aattggagag gtgtccagtg    360

gctccgggga gacgttcagc taccctgact ttctcaggat gatgctgggc aagagatctg    420

ccatcctaaa aatgatcctg atgtatgagg aaaaagcgag agaaaaggaa aagccaacag    480

gccccccagc caagaaagct atctctgagt tgccctgatt tgaagggaaa agggatgatg    540

ggattgaagg ggcttctaat gacccagata tggaaacaga agacaaaatt gtaagccaga    600

gtcaacaaat taaataaatt accccctcct ccagatcaa                           639


<210>  1531
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  1531

Met Ser Gln Thr Arg Asp Leu Gln Gly Gly Lys Ala Phe Gly Leu Leu 
1               5                   10                  15      


Lys Ala Gln Gln Glu Glu Arg Leu Asp Glu Ile Asn Lys Gln Phe Leu 
            20                  25                  30          


Asp Asp Pro Lys Tyr Ser Ser Asp Glu Asp Leu Pro Ser Lys Leu Glu 
        35                  40                  45              


Gly Phe Lys Glu Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp 
    50                  55                  60                  


Ile Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro 
65                  70                  75                  80  


Lys Thr His Leu Glu Leu Lys Lys Leu Ile Gly Glu Val Ser Ser Gly 
                85                  90                  95      


Ser Gly Glu Thr Phe Ser Tyr Pro Asp Phe Leu Arg Met Met Leu Gly 
            100                 105                 110         


Lys Arg Ser Ala Ile Leu Lys Met Ile Leu Met Tyr Glu Glu Lys Ala 
        115                 120                 125             


Arg Glu Lys Glu Lys Pro Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser 
    130                 135                 140                 


Glu Leu Pro 
145         


<210>  1532
<211>  1363
<212>  DNA
<213>  Homosapiens

<400>  1532
gaggaaaagc tttcggactg ctgaaggccc agcaggaaga gaggctggat gagatcaaca     60

agcaattcct agacgatccc aaatatagca gtgatgagga tctgccctcc aaactggaag    120

gcttcaaagg tgagggggaa actgtaggcg gtggagacag ggctgggggt aggagggtta    180

ggatttccac aagaacaagg caggaacagc agagataaaa agtttacttt tgtggtagca    240

aaaggggaac ctgcctttat tgccctcctg ccacactgcg gtccctttcc cgggcctgcc    300

tctctcagca tcccctctag ctccttacac cctagcgggg cccctcaact ccccaacccc    360

acttcctctg cctgcccctc ctcctccttc cacgttgtct cctccaccta gcagttggtt    420

ggcaacccct tcctcactca cccagagaaa tacatggagt ttgaccttaa tggaaatggc    480

gatattggtg agaaacgggt gatttgcggg ggcagggtgg tgtgcaggcc taagaagaca    540

gaggtctctc ctacatgctc cattcctcat gatttgggag ggggcccacc taccacagtg    600

ggaggaagga gaatggggat gcggaagtgg gagaggagag agagggtctc cccaccttct    660

ccccatcccc atcctctgcc cccagatatc atgtccctga aacgaatgct ggagaaactt    720

ggagtcccca agactcacct agagctaaag aaattaattg gagaggtgtc cagtggctcc    780

ggggagacgt tcagctaccc tgactttctc aggatgatgc tgggcaagag atctgccatc    840

ctaaaaatgt gagtgtcaat ttccaacctc ccctgtactt acctgttttc tcctccccca    900

tccctaccct tgtccacagg ctcaacattt ctacacgttg cccatcatcc cttcttccat    960

ccttagaggg acccttccaa ggtcccgacc ccatccctat ccatagtcct ggtccccaga   1020

aactccaacc cctgcccttc ctcttccccc ttccaccctc acatccccat ccccttctag   1080

cctttcctag caccctatga tttattccct tgagaggagt gttccctgat ccctgtgcct   1140

cttcccatct caaccaggat cctgatgtat gaggaaaaag cgagagaaaa ggaaaagcca   1200

acaggccccc cagccaagaa agctatctct gagttgccct gatttgaagg gaaaagggat   1260

gatgggattg aaggggcttc taatgaccca gatatggaaa cagaagacaa aattgtaagc   1320

cagagtcaac aaattaaata aattaccccc tcctccagat caa                     1363


<210>  1533
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  1533

Met Glu Phe Asp Leu Asn Gly Asn Gly Asp Ile Gly Glu Lys Arg Val 
1               5                   10                  15      


Ile Cys Gly Gly Arg Val Val Cys Arg Pro Lys Lys Thr Glu Val Ser 
            20                  25                  30          


Pro Thr Cys Ser Ile Pro His Asp Leu Gly Gly Gly Pro Pro Thr Thr 
        35                  40                  45              


Val Gly Gly Arg Arg Met Gly Met Arg Lys Trp Glu Arg Arg Glu Arg 
    50                  55                  60                  


Val Ser Pro Pro Ser Pro His Pro His Pro Leu Pro Pro Asp Ile Met 
65                  70                  75                  80  


Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro Lys Thr His Leu 
                85                  90                  95      


Glu Leu Lys Lys Leu Ile Gly Glu Val Ser Ser Gly Ser Gly Glu Thr 
            100                 105                 110         


Phe Ser Tyr Pro Asp Phe Leu Arg Met Met Leu Gly Lys Arg Ser Ala 
        115                 120                 125             


Ile Leu Lys Met 
    130         


<210>  1534
<211>  503
<212>  DNA
<213>  Homosapiens

<400>  1534
cacctagcag ttggttggca accccttcct cagtcccctg ctgaaaaccc tccagtcagc     60

gcttatccct tctgctctct cccctcaccc agagaaatac atggagtttg accttaatgg    120

aaatggcgat attgatatca tgtccctgaa acgaatgctg gagaaacttg gagtccccaa    180

gactcaccta gagctaaaga aattaattgg agaggtgtcc agtggctccg gggagacgtt    240

cagctaccct gactttctca ggatgatgct gggcaagaga tctgccatcc taaaaatgat    300

cctgatgtat gaggaaaaag cgagagaaaa ggaaaagcca acaggccccc cagccaagaa    360

agctatctct gagttgccct gatttgaagg gaaaagggat gatgggattg aaggggcttc    420

taatgaccca gatatggaaa cagaagacaa aattgtaagc cagagtcaac aaattaaata    480

aattaccccc tcctccagat caa                                            503


<210>  1535
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  1535

Met Glu Phe Asp Leu Asn Gly Asn Gly Asp Ile Asp Ile Met Ser Leu 
1               5                   10                  15      


Lys Arg Met Leu Glu Lys Leu Gly Val Pro Lys Thr His Leu Glu Leu 
            20                  25                  30          


Lys Lys Leu Ile Gly Glu Val Ser Ser Gly Ser Gly Glu Thr Phe Ser 
        35                  40                  45              


Tyr Pro Asp Phe Leu Arg Met Met Leu Gly Lys Arg Ser Ala Ile Leu 
    50                  55                  60                  


Lys Met Ile Leu Met Tyr Glu Glu Lys Ala Arg Glu Lys Glu Lys Pro 
65                  70                  75                  80  


Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser Glu Leu Pro 
                85                  90              


<210>  1536
<211>  6714
<212>  DNA
<213>  Homosapiens

<400>  1536
ccctaggccc gggtcccgga tccccgcgca cccggccagg ctctggcacg ttttggggga     60

ggtgcctgca ggacccaaca tactcaatga gcttccagcg caatgtccga tcgctcgggg    120

ccgactgcca agggaaagga tggaaagaag tattcctcgc tcaacctgtt tgatacgtat    180

aagggcaagt ccttagagat ccagaaaccc gctgttgccc ctcgccatgg cctgcagagt    240

ctcgggaaag ttgccattgc ccggcgtatg ccacctccag ccaaccttcc aagcctgaaa    300

gccgagaaca aaggcaatga ccccaatgtc tcactagtgc caaaagacgg aacaggatgg    360

gcaagcaaac aggagcagtc cgaccccaag agttccgatg cctcaaccgc tcagccgccg    420

gaatcgcagc cactgccggc ttcacagacg cctgcctcca accagccgaa acgaccccca    480

gcagcccccg agaacactcc tttggttcca agcggggtaa agtcctgggc acaagccagc    540

gtcacccatg gagcacatgg agatggtgga agggcatcaa gcctactgtc acgattctct    600

cgagaggaat ttccgaccct gcaggcggct ggcgaccagg acaaggctgc caaggaaagg    660

gagtctgccg aacagtcgtc tgggcccgga ccaagcctcc gcccccaaaa ttctacaact    720

tggagggacg gaggtgggcg tggccctgat gagctggagg gcccggactc caaacttcat    780

catggtcatg atccccgggg tgggctacag ccttcaggcc caccccagtt ccctccctac    840

cgcggaatga tgccgccttt catgtatccc ccatatctcc cgttccctcc gccctatgga    900

ccccaggggc cttaccgata ccccactcct gatgggccca gccgttttcc ccgtgtggcg    960

ggcccccgag gctcagggcc accaatgcgc ttagtagagc ctgtgggtcg tccctctatt   1020

ctcaaagagg ataatctcaa agagtttgat cagttggatc aggagaatga tgatggttgg   1080

gcaggggccc atgaagaggt tgactacact gaaaagctca agttcagcga tgaggaagat   1140

gggcgagact ctgatgagga gggagctgag ggccacaggg attcccaatc agcttctggt   1200

gaggaacggc cccctgaagc agatggcaaa aagggcaact cccccaacag cgaaccgccc   1260

actcctaaga cggcctgggc agaaacctct cggcctccag agacagagcc gggacctcct   1320

gccccaaagc ctcccctacc ccctggggac tacccagatc gtgggggtcc tccctgcaag   1380

cccccagcac ctgaagatga ggatgaggca tggcggcagc gacgaaagca gtcgtcatct   1440

gagatttccc tggcagtgga gcgggcccgg cgacggcgag aagaagagga gcggcgcatg   1500

caagaagagc gccgggcagc ctgtgctgag aagctcaagc gactcgatga aaagtttggg   1560

gcacctgaca agcggctcaa agcagagcct gctgccccac ctgctgcccc ttctacccca   1620

gctccaccac ctgcagtccc taaagaactc cctgcacctc cagctccacc tccagcatca   1680

gccccaacac cagagaaaga acctgaagag ccagcacagg cccctcctgc ccaatctact   1740

cctactccag gtgtggctgc ggctcccact ctggtgagtg gtggtggcag taccagtagc   1800

accagcagtg gcagcttcga agccagccca gtggaaccac aactgccctc aaaagagggt   1860

cctgaaccac cagaagaggt tcctcctcct accacacccc cagttccaaa ggtggaaccc   1920

aagggtgatg ggattggtcc cacccgccag ccccctagtc agggcttggg ctaccccaaa   1980

tatcagaagt cgttgcctcc tcgtttccag cggcagcagc aggagcagct cctgaagcag   2040

cagcagcagc accagtggca gcagcatcaa cagggctctg cccctcctac cccagtgccc   2100

ccatcaccac cacagcctgt gaccctgggg gctgtgccag ctccacaggc tccacccccg   2160

ccccccaagg ccctgtaccc aggtgctctg ggccggcccc cacccatgcc cccaatgaac   2220

tttgatcccc gatggatgat gattcctcct tatgtggacc cccggctcct ccagggtcgt   2280

ccccctctag acttctaccc tcctggtgtg catccctctg gcctagttcc ccgagagcgt   2340

tcagacagtg ggggctcaag ctcagagcca tttgaccgtc atgcacctgc tatgttacgg   2400

gaacggggca ctccaccggt ggatccaaag ttggcctggg taggagatgt cttcaccgcc   2460

acacccgctg aaccccgccc acttacctca cctctgcgcc aggctgcgga tgaggatgac   2520

aaggggatga ggagcgagac tcctccagta cctcccccac caccctatct ggccagttat   2580

ccaggctttc ctgagaatgg agcccctggg cccccaatct ctcgctttcc tctggaggaa   2640

ccagggcccc gtccactccc ctggccccca ggcagtgatg aagtggccaa gatacaaact   2700

ccaccaccca agaaggagcc ccctaaggag gagactgcac agctgacggg gccagaagca   2760

ggccgaaagc ctgcccgcgg agtcgggagt ggaggccagg gccccccacc accacgcaga   2820

gagagtcgca cagagacccg ctggggccct cgtccaggga gcagtcgtcg tggaatccct   2880

ccagaggagc caggggcccc accccgccgg gctgggccta taaagaaacc tccaccacct   2940

acaaaagtag aagagctgcc tcccaagccc ctcgaacagg gggatgaaac ccccaaaccc   3000

ccaaagccag acccactcaa gataaccaag gggaagctag ggggccccaa ggagacccca   3060

cccaatggaa atctttcccc tgccccaagg cttcggaggg actattcgta tgaaagagtg   3120

ggtcctacct cttgccgggg tcggggccga ggcgagtatt ttgccagagg gaggggtttt   3180

cgggggacct atgggggacg agggcgggga gcccgaagcc gggaattccg cagttaccga   3240

gagtttcgag gagatgatgg gcgtggaggt gggacagggg gaccaaacca ccctcctgct   3300

ccccgaggcc gcactgccag cgagacacgg agcgagggtt cagagtatga ggaaatcccc   3360

aagcggcgcc ggcagcgggg ctcagaaaca ggcagcgaga cccatgagag tgatctggct   3420

ccttcagaca aggaggctcc cacacccaag gagggaacac tcacccaggt ccctctcgct   3480

cccccaccac caggagcccc accttcacca gccccagccc gcttcactgc ccggggtggg   3540

cgagtcttca ctcccagagg ggtgccatct cgccggggcc gaggaggagg gaggccccct   3600

cctcaagttt gcccaggctg gagccctcca gccaagtctc tggctcccaa gaaacctccc   3660

acaggccctt tgccaccaag taaggagcct ttgaaagaga agttgatccc agggcctctg   3720

tcccctgtgg cgcgcggagg cagcaatgga ggtagcaatg tgggcatgga agatggggag   3780

cgaccccgaa ggaggcgaca tgggagggct cagcagcagg ataaaccgcc tcgtttccgg   3840

aggctgaagc aggaacggga gaatgccgca agggggtctg agggcaagcc ctccctaacc   3900

cttccagcct ccgctcctgc acctgaggag gccctcacaa cagtcacagt ggccccagca   3960

cctcgccggg cagctgccaa gtctcctgat ctgtcaaacc agaactcaga ccaagccaat   4020

gaggaatggg agactgcatc agagagcagt gacttcacca gtgagcgccg aggggacaaa   4080

gaggcacccc caccagtact gctgacaccc aaggctgtgg gaactcctgg gggaggtgga   4140

ggtggagccg taccaggtat ttcagccatg tcccgcggag atctgagcca gagagccaag   4200

gatttgagta aacggagctt ctcaagtcag cggccaggca tggaacggca gaatcggcgc   4260

cctggcccag ggggcaaggc tggcagcagt ggcagcagca gtggaggagg cggtgggggt   4320

cctggaggaa ggaccgggcc aggacgaggc gacaagagga gctggccctc tcccaagaac   4380

cgaagtcgtc ctccagagga gcgtcccccg gggcttcccc tgcctccccc acctcccagc   4440

agttctgctg tcttccgcct ggaccaagtt atccacagca accctgctgg catccaacag   4500

gctctggccc agcttagtag ccgtcaaggg agtgtaactg caccaggggg tcatccaagg   4560

cacaagcctg ggcctcccca agcccctcag ggcccctctc ctaggccccc aacccgatac   4620

gagccccaga gggtcaacag cggcctcagt tctgaccccc actttgagga gccggggcca   4680

atggtgagag gggtgggtgg gactcctcgg gactctgccg gggttagtcc ctttccccct   4740

aaacgtcggg agcggcctcc cagaaaacca gagctgctac aggaggaatc tttgccacct   4800

cctcatagct ctggattctt gggctctaag cctgagggcc caggccctca ggcagagtcc   4860

agagatacag gcacagaggc cctgacccct cacatctgga accgtttaca tactgccact   4920

agccgaaaga gttaccggcc cagctccatg gagccttgga tggagcccct gagtcctttt   4980

gaggatgtgg ctggcacaga aatgagtcag tctgacagtg gggtggacct gagtggggat   5040

tctcaggtgt catcaggtcc ctgcagccag cgaagttccc ctgatggagg actcaagggg   5100

gcagcagagg gaccccccaa gaggcctgga ggctcctcac ccctgaatgc tgttccttgt   5160

gagggtccac ctggctctga acctcctagg agaccaccac ctgcccccca cgatggggac   5220

agaaaggagc tgccccggga gcagcctctg ccccctggcc ccattggcac agaacgatca   5280

cagcatacag accgaggcac agagcctggc cccattcggc catcccatcg acctggtccc   5340

ccagtccagt ttggcactag tgacaaggac tcagacttac gcctagtggt aggagacagc   5400

ttgaaagcag agaaggagct aacagcatca gtcactgagg ccattcctgt atcacgagac   5460

tgggagctgc ttcccagtgc tgctgcctct gctgagccac aatccaagaa cctggattct   5520

gggcactgtg tcccggagcc cagctcctca ggccagcgcc tgtatcctga ggttttctat   5580

ggcagtgctg ggccttccag ttctcagatc tctgggggag ccatggactc tcaattacat   5640

ccaaacagtg gaggcttccg ccctgggaca ccctcactgc acccttacag atcacagccc   5700

ctatacctac cccccggccc agcccctccc tcagcactgc tctctggggt agctctcaag   5760

ggccagtttc tggatttctc cacaatgcaa gctacagagc tggggaagtt gccggctgga   5820

ggagttctct accctccacc ttccttcctc tactctccgg ctttctgccc cagtcctttg   5880

cctgacacat cgttgcttca ggtacgccag gatctgccat ccccttcgga tttttattct   5940

actcctctgc agcctggtgg ccaaagtggc tttctccctt caggggctcc tgcccagcag   6000

atgcttctac ccatggtaga ctcacagctg cctgtggtga actttggctc cctgccgcca   6060

gcaccacctc ctgccccacc tcccctttct ctgttacctg tgggccctgc tctgcagccc   6120

cccagcctgg ctgtgcggcc cccacctgct cctgctactc gggtgctgcc ttcacctgcc   6180

aggcccttcc ccgctagctt ggggcgagca gagctgcatc cagtggaact aaagccgttc   6240

caggattatc aaaaactgag cagcaacctt gggggacctg gatcatcacg gactccccca   6300

actggaaggt ccttctctgg cctcaattcc cgtctcaagg ccacgccttc cacctacagt   6360

ggagtcttcc gcacccagcg cgtcgacctt taccagcagg cctccccacc agatgccctg   6420

cgctggatac ctaagccttg ggagcggaca gggctgccac ctcgagaagg gccctcccga   6480

cgggcagagg agcctgggtc ccgaggggac aaggagcctg ggttgccccc accccgctga   6540

gggagttcct cttgccccct acccccgggg cttgtatata gattataaat atataagggg   6600

gaaaggggtg ggcggggagg ggttgtgggg ctggggcctc acttcccctc ctcccccttc   6660

ccctggtccc ctgtccctgg ggctgtttgt taaaaaagag taataaaagg attt         6714


<210>  1537
<211>  2145
<212>  PRT
<213>  Homosapiens

<400>  1537

Met Ser Asp Arg Ser Gly Pro Thr Ala Lys Gly Lys Asp Gly Lys Lys 
1               5                   10                  15      


Tyr Ser Ser Leu Asn Leu Phe Asp Thr Tyr Lys Gly Lys Ser Leu Glu 
            20                  25                  30          


Ile Gln Lys Pro Ala Val Ala Pro Arg His Gly Leu Gln Ser Leu Gly 
        35                  40                  45              


Lys Val Ala Ile Ala Arg Arg Met Pro Pro Pro Ala Asn Leu Pro Ser 
    50                  55                  60                  


Leu Lys Ala Glu Asn Lys Gly Asn Asp Pro Asn Val Ser Leu Val Pro 
65                  70                  75                  80  


Lys Asp Gly Thr Gly Trp Ala Ser Lys Gln Glu Gln Ser Asp Pro Lys 
                85                  90                  95      


Ser Ser Asp Ala Ser Thr Ala Gln Pro Pro Glu Ser Gln Pro Leu Pro 
            100                 105                 110         


Ala Ser Gln Thr Pro Ala Ser Asn Gln Pro Lys Arg Pro Pro Ala Ala 
        115                 120                 125             


Pro Glu Asn Thr Pro Leu Val Pro Ser Gly Val Lys Ser Trp Ala Gln 
    130                 135                 140                 


Ala Ser Val Thr His Gly Ala His Gly Asp Gly Gly Arg Ala Ser Ser 
145                 150                 155                 160 


Leu Leu Ser Arg Phe Ser Arg Glu Glu Phe Pro Thr Leu Gln Ala Ala 
                165                 170                 175     


Gly Asp Gln Asp Lys Ala Ala Lys Glu Arg Glu Ser Ala Glu Gln Ser 
            180                 185                 190         


Ser Gly Pro Gly Pro Ser Leu Arg Pro Gln Asn Ser Thr Thr Trp Arg 
        195                 200                 205             


Asp Gly Gly Gly Arg Gly Pro Asp Glu Leu Glu Gly Pro Asp Ser Lys 
    210                 215                 220                 


Leu His His Gly His Asp Pro Arg Gly Gly Leu Gln Pro Ser Gly Pro 
225                 230                 235                 240 


Pro Gln Phe Pro Pro Tyr Arg Gly Met Met Pro Pro Phe Met Tyr Pro 
                245                 250                 255     


Pro Tyr Leu Pro Phe Pro Pro Pro Tyr Gly Pro Gln Gly Pro Tyr Arg 
            260                 265                 270         


Tyr Pro Thr Pro Asp Gly Pro Ser Arg Phe Pro Arg Val Ala Gly Pro 
        275                 280                 285             


Arg Gly Ser Gly Pro Pro Met Arg Leu Val Glu Pro Val Gly Arg Pro 
    290                 295                 300                 


Ser Ile Leu Lys Glu Asp Asn Leu Lys Glu Phe Asp Gln Leu Asp Gln 
305                 310                 315                 320 


Glu Asn Asp Asp Gly Trp Ala Gly Ala His Glu Glu Val Asp Tyr Thr 
                325                 330                 335     


Glu Lys Leu Lys Phe Ser Asp Glu Glu Asp Gly Arg Asp Ser Asp Glu 
            340                 345                 350         


Glu Gly Ala Glu Gly His Arg Asp Ser Gln Ser Ala Ser Gly Glu Glu 
        355                 360                 365             


Arg Pro Pro Glu Ala Asp Gly Lys Lys Gly Asn Ser Pro Asn Ser Glu 
    370                 375                 380                 


Pro Pro Thr Pro Lys Thr Ala Trp Ala Glu Thr Ser Arg Pro Pro Glu 
385                 390                 395                 400 


Thr Glu Pro Gly Pro Pro Ala Pro Lys Pro Pro Leu Pro Pro Gly Asp 
                405                 410                 415     


Tyr Pro Asp Arg Gly Gly Pro Pro Cys Lys Pro Pro Ala Pro Glu Asp 
            420                 425                 430         


Glu Asp Glu Ala Trp Arg Gln Arg Arg Lys Gln Ser Ser Ser Glu Ile 
        435                 440                 445             


Ser Leu Ala Val Glu Arg Ala Arg Arg Arg Arg Glu Glu Glu Glu Arg 
    450                 455                 460                 


Arg Met Gln Glu Glu Arg Arg Ala Ala Cys Ala Glu Lys Leu Lys Arg 
465                 470                 475                 480 


Leu Asp Glu Lys Phe Gly Ala Pro Asp Lys Arg Leu Lys Ala Glu Pro 
                485                 490                 495     


Ala Ala Pro Pro Ala Ala Pro Ser Thr Pro Ala Pro Pro Pro Ala Val 
            500                 505                 510         


Pro Lys Glu Leu Pro Ala Pro Pro Ala Pro Pro Pro Ala Ser Ala Pro 
        515                 520                 525             


Thr Pro Glu Lys Glu Pro Glu Glu Pro Ala Gln Ala Pro Pro Ala Gln 
    530                 535                 540                 


Ser Thr Pro Thr Pro Gly Val Ala Ala Ala Pro Thr Leu Val Ser Gly 
545                 550                 555                 560 


Gly Gly Ser Thr Ser Ser Thr Ser Ser Gly Ser Phe Glu Ala Ser Pro 
                565                 570                 575     


Val Glu Pro Gln Leu Pro Ser Lys Glu Gly Pro Glu Pro Pro Glu Glu 
            580                 585                 590         


Val Pro Pro Pro Thr Thr Pro Pro Val Pro Lys Val Glu Pro Lys Gly 
        595                 600                 605             


Asp Gly Ile Gly Pro Thr Arg Gln Pro Pro Ser Gln Gly Leu Gly Tyr 
    610                 615                 620                 


Pro Lys Tyr Gln Lys Ser Leu Pro Pro Arg Phe Gln Arg Gln Gln Gln 
625                 630                 635                 640 


Glu Gln Leu Leu Lys Gln Gln Gln Gln His Gln Trp Gln Gln His Gln 
                645                 650                 655     


Gln Gly Ser Ala Pro Pro Thr Pro Val Pro Pro Ser Pro Pro Gln Pro 
            660                 665                 670         


Val Thr Leu Gly Ala Val Pro Ala Pro Gln Ala Pro Pro Pro Pro Pro 
        675                 680                 685             


Lys Ala Leu Tyr Pro Gly Ala Leu Gly Arg Pro Pro Pro Met Pro Pro 
    690                 695                 700                 


Met Asn Phe Asp Pro Arg Trp Met Met Ile Pro Pro Tyr Val Asp Pro 
705                 710                 715                 720 


Arg Leu Leu Gln Gly Arg Pro Pro Leu Asp Phe Tyr Pro Pro Gly Val 
                725                 730                 735     


His Pro Ser Gly Leu Val Pro Arg Glu Arg Ser Asp Ser Gly Gly Ser 
            740                 745                 750         


Ser Ser Glu Pro Phe Asp Arg His Ala Pro Ala Met Leu Arg Glu Arg 
        755                 760                 765             


Gly Thr Pro Pro Val Asp Pro Lys Leu Ala Trp Val Gly Asp Val Phe 
    770                 775                 780                 


Thr Ala Thr Pro Ala Glu Pro Arg Pro Leu Thr Ser Pro Leu Arg Gln 
785                 790                 795                 800 


Ala Ala Asp Glu Asp Asp Lys Gly Met Arg Ser Glu Thr Pro Pro Val 
                805                 810                 815     


Pro Pro Pro Pro Pro Tyr Leu Ala Ser Tyr Pro Gly Phe Pro Glu Asn 
            820                 825                 830         


Gly Ala Pro Gly Pro Pro Ile Ser Arg Phe Pro Leu Glu Glu Pro Gly 
        835                 840                 845             


Pro Arg Pro Leu Pro Trp Pro Pro Gly Ser Asp Glu Val Ala Lys Ile 
    850                 855                 860                 


Gln Thr Pro Pro Pro Lys Lys Glu Pro Pro Lys Glu Glu Thr Ala Gln 
865                 870                 875                 880 


Leu Thr Gly Pro Glu Ala Gly Arg Lys Pro Ala Arg Gly Val Gly Ser 
                885                 890                 895     


Gly Gly Gln Gly Pro Pro Pro Pro Arg Arg Glu Ser Arg Thr Glu Thr 
            900                 905                 910         


Arg Trp Gly Pro Arg Pro Gly Ser Ser Arg Arg Gly Ile Pro Pro Glu 
        915                 920                 925             


Glu Pro Gly Ala Pro Pro Arg Arg Ala Gly Pro Ile Lys Lys Pro Pro 
    930                 935                 940                 


Pro Pro Thr Lys Val Glu Glu Leu Pro Pro Lys Pro Leu Glu Gln Gly 
945                 950                 955                 960 


Asp Glu Thr Pro Lys Pro Pro Lys Pro Asp Pro Leu Lys Ile Thr Lys 
                965                 970                 975     


Gly Lys Leu Gly Gly Pro Lys Glu Thr Pro Pro Asn Gly Asn Leu Ser 
            980                 985                 990         


Pro Ala Pro Arg Leu Arg Arg Asp  Tyr Ser Tyr Glu Arg  Val Gly Pro 
        995                 1000                 1005             


Thr Ser  Cys Arg Gly Arg Gly  Arg Gly Glu Tyr Phe  Ala Arg Gly 
    1010                 1015                 1020             


Arg Gly  Phe Arg Gly Thr Tyr  Gly Gly Arg Gly Arg  Gly Ala Arg 
    1025                 1030                 1035             


Ser Arg  Glu Phe Arg Ser Tyr  Arg Glu Phe Arg Gly  Asp Asp Gly 
    1040                 1045                 1050             


Arg Gly  Gly Gly Thr Gly Gly  Pro Asn His Pro Pro  Ala Pro Arg 
    1055                 1060                 1065             


Gly Arg  Thr Ala Ser Glu Thr  Arg Ser Glu Gly Ser  Glu Tyr Glu 
    1070                 1075                 1080             


Glu Ile  Pro Lys Arg Arg Arg  Gln Arg Gly Ser Glu  Thr Gly Ser 
    1085                 1090                 1095             


Glu Thr  His Glu Ser Asp Leu  Ala Pro Ser Asp Lys  Glu Ala Pro 
    1100                 1105                 1110             


Thr Pro  Lys Glu Gly Thr Leu  Thr Gln Val Pro Leu  Ala Pro Pro 
    1115                 1120                 1125             


Pro Pro  Gly Ala Pro Pro Ser  Pro Ala Pro Ala Arg  Phe Thr Ala 
    1130                 1135                 1140             


Arg Gly  Gly Arg Val Phe Thr  Pro Arg Gly Val Pro  Ser Arg Arg 
    1145                 1150                 1155             


Gly Arg  Gly Gly Gly Arg Pro  Pro Pro Gln Val Cys  Pro Gly Trp 
    1160                 1165                 1170             


Ser Pro  Pro Ala Lys Ser Leu  Ala Pro Lys Lys Pro  Pro Thr Gly 
    1175                 1180                 1185             


Pro Leu  Pro Pro Ser Lys Glu  Pro Leu Lys Glu Lys  Leu Ile Pro 
    1190                 1195                 1200             


Gly Pro  Leu Ser Pro Val Ala  Arg Gly Gly Ser Asn  Gly Gly Ser 
    1205                 1210                 1215             


Asn Val  Gly Met Glu Asp Gly  Glu Arg Pro Arg Arg  Arg Arg His 
    1220                 1225                 1230             


Gly Arg  Ala Gln Gln Gln Asp  Lys Pro Pro Arg Phe  Arg Arg Leu 
    1235                 1240                 1245             


Lys Gln  Glu Arg Glu Asn Ala  Ala Arg Gly Ser Glu  Gly Lys Pro 
    1250                 1255                 1260             


Ser Leu  Thr Leu Pro Ala Ser  Ala Pro Ala Pro Glu  Glu Ala Leu 
    1265                 1270                 1275             


Thr Thr  Val Thr Val Ala Pro  Ala Pro Arg Arg Ala  Ala Ala Lys 
    1280                 1285                 1290             


Ser Pro  Asp Leu Ser Asn Gln  Asn Ser Asp Gln Ala  Asn Glu Glu 
    1295                 1300                 1305             


Trp Glu  Thr Ala Ser Glu Ser  Ser Asp Phe Thr Ser  Glu Arg Arg 
    1310                 1315                 1320             


Gly Asp  Lys Glu Ala Pro Pro  Pro Val Leu Leu Thr  Pro Lys Ala 
    1325                 1330                 1335             


Val Gly  Thr Pro Gly Gly Gly  Gly Gly Gly Ala Val  Pro Gly Ile 
    1340                 1345                 1350             


Ser Ala  Met Ser Arg Gly Asp  Leu Ser Gln Arg Ala  Lys Asp Leu 
    1355                 1360                 1365             


Ser Lys  Arg Ser Phe Ser Ser  Gln Arg Pro Gly Met  Glu Arg Gln 
    1370                 1375                 1380             


Asn Arg  Arg Pro Gly Pro Gly  Gly Lys Ala Gly Ser  Ser Gly Ser 
    1385                 1390                 1395             


Ser Ser  Gly Gly Gly Gly Gly  Gly Pro Gly Gly Arg  Thr Gly Pro 
    1400                 1405                 1410             


Gly Arg  Gly Asp Lys Arg Ser  Trp Pro Ser Pro Lys  Asn Arg Ser 
    1415                 1420                 1425             


Arg Pro  Pro Glu Glu Arg Pro  Pro Gly Leu Pro Leu  Pro Pro Pro 
    1430                 1435                 1440             


Pro Pro  Ser Ser Ser Ala Val  Phe Arg Leu Asp Gln  Val Ile His 
    1445                 1450                 1455             


Ser Asn  Pro Ala Gly Ile Gln  Gln Ala Leu Ala Gln  Leu Ser Ser 
    1460                 1465                 1470             


Arg Gln  Gly Ser Val Thr Ala  Pro Gly Gly His Pro  Arg His Lys 
    1475                 1480                 1485             


Pro Gly  Pro Pro Gln Ala Pro  Gln Gly Pro Ser Pro  Arg Pro Pro 
    1490                 1495                 1500             


Thr Arg  Tyr Glu Pro Gln Arg  Val Asn Ser Gly Leu  Ser Ser Asp 
    1505                 1510                 1515             


Pro His  Phe Glu Glu Pro Gly  Pro Met Val Arg Gly  Val Gly Gly 
    1520                 1525                 1530             


Thr Pro  Arg Asp Ser Ala Gly  Val Ser Pro Phe Pro  Pro Lys Arg 
    1535                 1540                 1545             


Arg Glu  Arg Pro Pro Arg Lys  Pro Glu Leu Leu Gln  Glu Glu Ser 
    1550                 1555                 1560             


Leu Pro  Pro Pro His Ser Ser  Gly Phe Leu Gly Ser  Lys Pro Glu 
    1565                 1570                 1575             


Gly Pro  Gly Pro Gln Ala Glu  Ser Arg Asp Thr Gly  Thr Glu Ala 
    1580                 1585                 1590             


Leu Thr  Pro His Ile Trp Asn  Arg Leu His Thr Ala  Thr Ser Arg 
    1595                 1600                 1605             


Lys Ser  Tyr Arg Pro Ser Ser  Met Glu Pro Trp Met  Glu Pro Leu 
    1610                 1615                 1620             


Ser Pro  Phe Glu Asp Val Ala  Gly Thr Glu Met Ser  Gln Ser Asp 
    1625                 1630                 1635             


Ser Gly  Val Asp Leu Ser Gly  Asp Ser Gln Val Ser  Ser Gly Pro 
    1640                 1645                 1650             


Cys Ser  Gln Arg Ser Ser Pro  Asp Gly Gly Leu Lys  Gly Ala Ala 
    1655                 1660                 1665             


Glu Gly  Pro Pro Lys Arg Pro  Gly Gly Ser Ser Pro  Leu Asn Ala 
    1670                 1675                 1680             


Val Pro  Cys Glu Gly Pro Pro  Gly Ser Glu Pro Pro  Arg Arg Pro 
    1685                 1690                 1695             


Pro Pro  Ala Pro His Asp Gly  Asp Arg Lys Glu Leu  Pro Arg Glu 
    1700                 1705                 1710             


Gln Pro  Leu Pro Pro Gly Pro  Ile Gly Thr Glu Arg  Ser Gln His 
    1715                 1720                 1725             


Thr Asp  Arg Gly Thr Glu Pro  Gly Pro Ile Arg Pro  Ser His Arg 
    1730                 1735                 1740             


Pro Gly  Pro Pro Val Gln Phe  Gly Thr Ser Asp Lys  Asp Ser Asp 
    1745                 1750                 1755             


Leu Arg  Leu Val Val Gly Asp  Ser Leu Lys Ala Glu  Lys Glu Leu 
    1760                 1765                 1770             


Thr Ala  Ser Val Thr Glu Ala  Ile Pro Val Ser Arg  Asp Trp Glu 
    1775                 1780                 1785             


Leu Leu  Pro Ser Ala Ala Ala  Ser Ala Glu Pro Gln  Ser Lys Asn 
    1790                 1795                 1800             


Leu Asp  Ser Gly His Cys Val  Pro Glu Pro Ser Ser  Ser Gly Gln 
    1805                 1810                 1815             


Arg Leu  Tyr Pro Glu Val Phe  Tyr Gly Ser Ala Gly  Pro Ser Ser 
    1820                 1825                 1830             


Ser Gln  Ile Ser Gly Gly Ala  Met Asp Ser Gln Leu  His Pro Asn 
    1835                 1840                 1845             


Ser Gly  Gly Phe Arg Pro Gly  Thr Pro Ser Leu His  Pro Tyr Arg 
    1850                 1855                 1860             


Ser Gln  Pro Leu Tyr Leu Pro  Pro Gly Pro Ala Pro  Pro Ser Ala 
    1865                 1870                 1875             


Leu Leu  Ser Gly Val Ala Leu  Lys Gly Gln Phe Leu  Asp Phe Ser 
    1880                 1885                 1890             


Thr Met  Gln Ala Thr Glu Leu  Gly Lys Leu Pro Ala  Gly Gly Val 
    1895                 1900                 1905             


Leu Tyr  Pro Pro Pro Ser Phe  Leu Tyr Ser Pro Ala  Phe Cys Pro 
    1910                 1915                 1920             


Ser Pro  Leu Pro Asp Thr Ser  Leu Leu Gln Val Arg  Gln Asp Leu 
    1925                 1930                 1935             


Pro Ser  Pro Ser Asp Phe Tyr  Ser Thr Pro Leu Gln  Pro Gly Gly 
    1940                 1945                 1950             


Gln Ser  Gly Phe Leu Pro Ser  Gly Ala Pro Ala Gln  Gln Met Leu 
    1955                 1960                 1965             


Leu Pro  Met Val Asp Ser Gln  Leu Pro Val Val Asn  Phe Gly Ser 
    1970                 1975                 1980             


Leu Pro  Pro Ala Pro Pro Pro  Ala Pro Pro Pro Leu  Ser Leu Leu 
    1985                 1990                 1995             


Pro Val  Gly Pro Ala Leu Gln  Pro Pro Ser Leu Ala  Val Arg Pro 
    2000                 2005                 2010             


Pro Pro  Ala Pro Ala Thr Arg  Val Leu Pro Ser Pro  Ala Arg Pro 
    2015                 2020                 2025             


Phe Pro  Ala Ser Leu Gly Arg  Ala Glu Leu His Pro  Val Glu Leu 
    2030                 2035                 2040             


Lys Pro  Phe Gln Asp Tyr Gln  Lys Leu Ser Ser Asn  Leu Gly Gly 
    2045                 2050                 2055             


Pro Gly  Ser Ser Arg Thr Pro  Pro Thr Gly Arg Ser  Phe Ser Gly 
    2060                 2065                 2070             


Leu Asn  Ser Arg Leu Lys Ala  Thr Pro Ser Thr Tyr  Ser Gly Val 
    2075                 2080                 2085             


Phe Arg  Thr Gln Arg Val Asp  Leu Tyr Gln Gln Ala  Ser Pro Pro 
    2090                 2095                 2100             


Asp Ala  Leu Arg Trp Ile Pro  Lys Pro Trp Glu Arg  Thr Gly Leu 
    2105                 2110                 2115             


Pro Pro  Arg Glu Gly Pro Ser  Arg Arg Ala Glu Glu  Pro Gly Ser 
    2120                 2125                 2130             


Arg Gly  Asp Lys Glu Pro Gly  Leu Pro Pro Pro Arg  
    2135                 2140                 2145 


<210>  1538
<211>  6750
<212>  DNA
<213>  Homosapiens

<400>  1538
ccctaggccc gggtcccgga tccccgcgca cccggccagg ctctggcacg ttttggggga     60

ggtgcctgca ggacccaaca tactcaatga gcttccagcg caatgtccga tcgctcgggg    120

ccgactgcca agggaaagga tggaaagaag tattcctcgc tcaacctgtt tgatacgtat    180

aagggcaagt ccttagagat ccagaaaccc gctgttgccc ctcgccatgg cctgcagagt    240

ctcgggaaag ttgccattgc ccggcgtatg ccacctccag ccaaccttcc aagcctgaaa    300

gccgagaaca aaggcaatga ccccaatgtc tcactagtgc caaaagacgg aacaggatgg    360

gcaagcaaac aggagcagtc cgaccccaag agttccgatg cctcaaccgc tcagccgccg    420

gaatcgcagc cactgccggc ttcacagacg cctgcctcca accagccgaa acgaccccca    480

gcagcccccg agaacactcc tttggttcca agcggggtaa agtcctgggc acaagccagc    540

gtcacccatg gagcacatgg agatggtgga agggcatcaa gcctactgtc acgattctct    600

cgagaggaat ttccgaccct gcaggcggct ggcgaccagg acaaggctgc caaggaaagg    660

gagtctgccg aacagtcgtc tgggcccgga ccaagcctcc gcccccaaaa ttctacaact    720

tggagggacg gaggtgggcg tggccctgat gagctggagg gcccggactc caaacttcat    780

catggtcatg atccccgggg tgggctacag ccttcaggcc caccccagtt ccctccctac    840

cgcggaatga tgccgccttt catgtatccc ccatatctcc cgttccctcc gccctatgga    900

ccccaggggc cttaccgata ccccactcct gatgggccca gccgttttcc ccgtgtggcg    960

ggcccccgag gctcagggcc accaatgcgc ttagtagagc ctgtgggtcg tccctctatt   1020

ctcaaagagg ataatctcaa agagtttgat cagttggatc aggagaatga tgatggttgg   1080

gcaggggccc atgaagaggt tgactacact gaaaagctca agttcagcga tgaggaagat   1140

gggcgagact ctgatgagga gggagctgag ggccacaggg attcccaatc agcttctggt   1200

gaggaacggc cccctgaagc agatggcaaa aagggcaact cccccaacag cgaaccgccc   1260

actcctaaga cggcctgggc agaaacctct cggcctccag agacagagcc gggacctcct   1320

gccccaaagc ctcccctacc cccacctcac cggggccccg ccgggaactg gggcccccct   1380

ggggactacc cagatcgtgg gggtcctccc tgcaagcccc cagcacctga agatgaggat   1440

gaggcatggc ggcagcgacg aaagcagtcg tcatctgaga tttccctggc agtggagcgg   1500

gcccggcgac ggcgagaaga agaggagcgg cgcatgcaag aagagcgccg ggcagcctgt   1560

gctgagaagc tcaagcgact cgatgaaaag tttggggcac ctgacaagcg gctcaaagca   1620

gagcctgctg ccccacctgc tgccccttct accccagctc caccacctgc agtccctaaa   1680

gaactccctg cacctccagc tccacctcca gcatcagccc caacaccaga gaaagaacct   1740

gaagagccag cacaggcccc tcctgcccaa tctactccta ctccaggtgt ggctgcggct   1800

cccactctgg tgagtggtgg tggcagtacc agtagcacca gcagtggcag cttcgaagcc   1860

agcccagtgg aaccacaact gccctcaaaa gagggtcctg aaccaccaga agaggttcct   1920

cctcctacca cacccccagt tccaaaggtg gaacccaagg gtgatgggat tggtcccacc   1980

cgccagcccc ctagtcaggg cttgggctac cccaaatatc agaagtcgtt gcctcctcgt   2040

ttccagcggc agcagcagga gcagctcctg aagcagcagc agcagcacca gtggcagcag   2100

catcaacagg gctctgcccc tcctacccca gtgcccccat caccaccaca gcctgtgacc   2160

ctgggggctg tgccagctcc acaggctcca cccccgcccc ccaaggccct gtacccaggt   2220

gctctgggcc ggcccccacc catgccccca atgaactttg atccccgatg gatgatgatt   2280

cctccttatg tggacccccg gctcctccag ggtcgtcccc ctctagactt ctaccctcct   2340

ggtgtgcatc cctctggcct agttccccga gagcgttcag acagtggggg ctcaagctca   2400

gagccatttg accgtcatgc acctgctatg ttacgggaac ggggcactcc accggtggat   2460

ccaaagttgg cctgggtagg agatgtcttc accgccacac ccgctgaacc ccgcccactt   2520

acctcacctc tgcgccaggc tgcggatgag gatgacaagg ggatgaggag cgagactcct   2580

ccagtacctc ccccaccacc ctatctggcc agttatccag gctttcctga gaatggagcc   2640

cctgggcccc caatctctcg ctttcctctg gaggaaccag ggccccgtcc actcccctgg   2700

cccccaggca gtgatgaagt ggccaagata caaactccac cacccaagaa ggagccccct   2760

aaggaggaga ctgcacagct gacggggcca gaagcaggcc gaaagcctgc ccgcggagtc   2820

gggagtggag gccagggccc cccaccacca cgcagagaga gtcgcacaga gacccgctgg   2880

ggccctcgtc cagggagcag tcgtcgtgga atccctccag aggagccagg ggccccaccc   2940

cgccgggctg ggcctataaa gaaacctcca ccacctacaa aagtagaaga gctgcctccc   3000

aagcccctcg aacaggggga tgaaaccccc aaacccccaa agccagaccc actcaagata   3060

accaagggga agctaggggg ccccaaggag accccaccca atggaaatct ttcccctgcc   3120

ccaaggcttc ggagggacta ttcgtatgaa agagtgggtc ctacctcttg ccggggtcgg   3180

ggccgaggcg agtattttgc cagagggagg ggttttcggg ggacctatgg gggacgaggg   3240

cggggagccc gaagccggga attccgcagt taccgagagt ttcgaggaga tgatgggcgt   3300

ggaggtggga cagggggacc aaaccaccct cctgctcccc gaggccgcac tgccagcgag   3360

acacggagcg agggttcaga gtatgaggaa atccccaagc ggcgccggca gcggggctca   3420

gaaacaggca gcgagaccca tgagagtgat ctggctcctt cagacaagga ggctcccaca   3480

cccaaggagg gaacactcac ccaggtccct ctcgctcccc caccaccagg agccccacct   3540

tcaccagccc cagcccgctt cactgcccgg ggtgggcgag tcttcactcc cagaggggtg   3600

ccatctcgcc ggggccgagg aggagggagg ccccctcctc aagtttgccc aggctggagc   3660

cctccagcca agtctctggc tcccaagaaa cctcccacag gccctttgcc accaagtaag   3720

gagcctttga aagagaagtt gatcccaggg cctctgtccc ctgtggcgcg cggaggcagc   3780

aatggaggta gcaatgtggg catggaagat ggggagcgac cccgaaggag gcgacatggg   3840

agggctcagc agcaggataa accgcctcgt ttccggaggc tgaagcagga acgggagaat   3900

gccgcaaggg ggtctgaggg caagccctcc ctaacccttc cagcctccgc tcctgcacct   3960

gaggaggccc tcacaacagt cacagtggcc ccagcacctc gccgggcagc tgccaagtct   4020

cctgatctgt caaaccagaa ctcagaccaa gccaatgagg aatgggagac tgcatcagag   4080

agcagtgact tcaccagtga gcgccgaggg gacaaagagg cacccccacc agtactgctg   4140

acacccaagg ctgtgggaac tcctggggga ggtggaggtg gagccgtacc aggtatttca   4200

gccatgtccc gcggagatct gagccagaga gccaaggatt tgagtaaacg gagcttctca   4260

agtcagcggc caggcatgga acggcagaat cggcgccctg gcccaggggg caaggctggc   4320

agcagtggca gcagcagtgg aggaggcggt gggggtcctg gaggaaggac cgggccagga   4380

cgaggcgaca agaggagctg gccctctccc aagaaccgaa gtcgtcctcc agaggagcgt   4440

cccccggggc ttcccctgcc tcccccacct cccagcagtt ctgctgtctt ccgcctggac   4500

caagttatcc acagcaaccc tgctggcatc caacaggctc tggcccagct tagtagccgt   4560

caagggagtg taactgcacc agggggtcat ccaaggcaca agcctgggcc tccccaagcc   4620

cctcagggcc cctctcctag gcccccaacc cgatacgagc cccagagggt caacagcggc   4680

ctcagttctg acccccactt tgaggagccg gggccaatgg tgagaggggt gggtgggact   4740

cctcgggact ctgccggggt tagtcccttt ccccctaaac gtcgggagcg gcctcccaga   4800

aaaccagagc tgctacagga ggaatctttg ccacctcctc atagctctgg attcttgggc   4860

tctaagcctg agggcccagg ccctcaggca gagtccagag atacaggcac agaggccctg   4920

acccctcaca tctggaaccg tttacatact gccactagcc gaaagagtta ccggcccagc   4980

tccatggagc cttggatgga gcccctgagt ccttttgagg atgtggctgg cacagaaatg   5040

agtcagtctg acagtggggt ggacctgagt ggggattctc aggtgtcatc aggtccctgc   5100

agccagcgaa gttcccctga tggaggactc aagggggcag cagagggacc ccccaagagg   5160

cctggaggct cctcacccct gaatgctgtt ccttgtgagg gtccacctgg ctctgaacct   5220

cctaggagac caccacctgc cccccacgat ggggacagaa aggagctgcc ccgggagcag   5280

cctctgcccc ctggccccat tggcacagaa cgatcacagc atacagaccg aggcacagag   5340

cctggcccca ttcggccatc ccatcgacct ggtcccccag tccagtttgg cactagtgac   5400

aaggactcag acttacgcct agtggtagga gacagcttga aagcagagaa ggagctaaca   5460

gcatcagtca ctgaggccat tcctgtatca cgagactggg agctgcttcc cagtgctgct   5520

gcctctgctg agccacaatc caagaacctg gattctgggc actgtgtccc ggagcccagc   5580

tcctcaggcc agcgcctgta tcctgaggtt ttctatggca gtgctgggcc ttccagttct   5640

cagatctctg ggggagccat ggactctcaa ttacatccaa acagtggagg cttccgccct   5700

gggacaccct cactgcaccc ttacagatca cagcccctat acctaccccc cggcccagcc   5760

cctccctcag cactgctctc tggggtagct ctcaagggcc agtttctgga tttctccaca   5820

atgcaagcta cagagctggg gaagttgccg gctggaggag ttctctaccc tccaccttcc   5880

ttcctctact ctccggcttt ctgccccagt cctttgcctg acacatcgtt gcttcaggta   5940

cgccaggatc tgccatcccc ttcggatttt tattctactc ctctgcagcc tggtggccaa   6000

agtggctttc tcccttcagg ggctcctgcc cagcagatgc ttctacccat ggtagactca   6060

cagctgcctg tggtgaactt tggctccctg ccgccagcac cacctcctgc cccacctccc   6120

ctttctctgt tacctgtggg ccctgctctg cagcccccca gcctggctgt gcggccccca   6180

cctgctcctg ctactcgggt gctgccttca cctgccaggc ccttccccgc tagcttgggg   6240

cgagcagagc tgcatccagt ggaactaaag ccgttccagg attatcaaaa actgagcagc   6300

aaccttgggg gacctggatc atcacggact cccccaactg gaaggtcctt ctctggcctc   6360

aattcccgtc tcaaggccac gccttccacc tacagtggag tcttccgcac ccagcgcgtc   6420

gacctttacc agcaggcctc cccaccagat gccctgcgct ggatacctaa gccttgggag   6480

cggacagggc tgccacctcg agaagggccc tcccgacggg cagaggagcc tgggtcccga   6540

ggggacaagg agcctgggtt gcccccaccc cgctgaggga gttcctcttg ccccctaccc   6600

ccggggcttg tatatagatt ataaatatat aagggggaaa ggggtgggcg gggaggggtt   6660

gtggggctgg ggcctcactt cccctcctcc cccttcccct ggtcccctgt ccctggggct   6720

gtttgttaaa aaagagtaat aaaaggattt                                    6750


<210>  1539
<211>  2157
<212>  PRT
<213>  Homosapiens

<400>  1539

Met Ser Asp Arg Ser Gly Pro Thr Ala Lys Gly Lys Asp Gly Lys Lys 
1               5                   10                  15      


Tyr Ser Ser Leu Asn Leu Phe Asp Thr Tyr Lys Gly Lys Ser Leu Glu 
            20                  25                  30          


Ile Gln Lys Pro Ala Val Ala Pro Arg His Gly Leu Gln Ser Leu Gly 
        35                  40                  45              


Lys Val Ala Ile Ala Arg Arg Met Pro Pro Pro Ala Asn Leu Pro Ser 
    50                  55                  60                  


Leu Lys Ala Glu Asn Lys Gly Asn Asp Pro Asn Val Ser Leu Val Pro 
65                  70                  75                  80  


Lys Asp Gly Thr Gly Trp Ala Ser Lys Gln Glu Gln Ser Asp Pro Lys 
                85                  90                  95      


Ser Ser Asp Ala Ser Thr Ala Gln Pro Pro Glu Ser Gln Pro Leu Pro 
            100                 105                 110         


Ala Ser Gln Thr Pro Ala Ser Asn Gln Pro Lys Arg Pro Pro Ala Ala 
        115                 120                 125             


Pro Glu Asn Thr Pro Leu Val Pro Ser Gly Val Lys Ser Trp Ala Gln 
    130                 135                 140                 


Ala Ser Val Thr His Gly Ala His Gly Asp Gly Gly Arg Ala Ser Ser 
145                 150                 155                 160 


Leu Leu Ser Arg Phe Ser Arg Glu Glu Phe Pro Thr Leu Gln Ala Ala 
                165                 170                 175     


Gly Asp Gln Asp Lys Ala Ala Lys Glu Arg Glu Ser Ala Glu Gln Ser 
            180                 185                 190         


Ser Gly Pro Gly Pro Ser Leu Arg Pro Gln Asn Ser Thr Thr Trp Arg 
        195                 200                 205             


Asp Gly Gly Gly Arg Gly Pro Asp Glu Leu Glu Gly Pro Asp Ser Lys 
    210                 215                 220                 


Leu His His Gly His Asp Pro Arg Gly Gly Leu Gln Pro Ser Gly Pro 
225                 230                 235                 240 


Pro Gln Phe Pro Pro Tyr Arg Gly Met Met Pro Pro Phe Met Tyr Pro 
                245                 250                 255     


Pro Tyr Leu Pro Phe Pro Pro Pro Tyr Gly Pro Gln Gly Pro Tyr Arg 
            260                 265                 270         


Tyr Pro Thr Pro Asp Gly Pro Ser Arg Phe Pro Arg Val Ala Gly Pro 
        275                 280                 285             


Arg Gly Ser Gly Pro Pro Met Arg Leu Val Glu Pro Val Gly Arg Pro 
    290                 295                 300                 


Ser Ile Leu Lys Glu Asp Asn Leu Lys Glu Phe Asp Gln Leu Asp Gln 
305                 310                 315                 320 


Glu Asn Asp Asp Gly Trp Ala Gly Ala His Glu Glu Val Asp Tyr Thr 
                325                 330                 335     


Glu Lys Leu Lys Phe Ser Asp Glu Glu Asp Gly Arg Asp Ser Asp Glu 
            340                 345                 350         


Glu Gly Ala Glu Gly His Arg Asp Ser Gln Ser Ala Ser Gly Glu Glu 
        355                 360                 365             


Arg Pro Pro Glu Ala Asp Gly Lys Lys Gly Asn Ser Pro Asn Ser Glu 
    370                 375                 380                 


Pro Pro Thr Pro Lys Thr Ala Trp Ala Glu Thr Ser Arg Pro Pro Glu 
385                 390                 395                 400 


Thr Glu Pro Gly Pro Pro Ala Pro Lys Pro Pro Leu Pro Pro Pro His 
                405                 410                 415     


Arg Gly Pro Ala Gly Asn Trp Gly Pro Pro Gly Asp Tyr Pro Asp Arg 
            420                 425                 430         


Gly Gly Pro Pro Cys Lys Pro Pro Ala Pro Glu Asp Glu Asp Glu Ala 
        435                 440                 445             


Trp Arg Gln Arg Arg Lys Gln Ser Ser Ser Glu Ile Ser Leu Ala Val 
    450                 455                 460                 


Glu Arg Ala Arg Arg Arg Arg Glu Glu Glu Glu Arg Arg Met Gln Glu 
465                 470                 475                 480 


Glu Arg Arg Ala Ala Cys Ala Glu Lys Leu Lys Arg Leu Asp Glu Lys 
                485                 490                 495     


Phe Gly Ala Pro Asp Lys Arg Leu Lys Ala Glu Pro Ala Ala Pro Pro 
            500                 505                 510         


Ala Ala Pro Ser Thr Pro Ala Pro Pro Pro Ala Val Pro Lys Glu Leu 
        515                 520                 525             


Pro Ala Pro Pro Ala Pro Pro Pro Ala Ser Ala Pro Thr Pro Glu Lys 
    530                 535                 540                 


Glu Pro Glu Glu Pro Ala Gln Ala Pro Pro Ala Gln Ser Thr Pro Thr 
545                 550                 555                 560 


Pro Gly Val Ala Ala Ala Pro Thr Leu Val Ser Gly Gly Gly Ser Thr 
                565                 570                 575     


Ser Ser Thr Ser Ser Gly Ser Phe Glu Ala Ser Pro Val Glu Pro Gln 
            580                 585                 590         


Leu Pro Ser Lys Glu Gly Pro Glu Pro Pro Glu Glu Val Pro Pro Pro 
        595                 600                 605             


Thr Thr Pro Pro Val Pro Lys Val Glu Pro Lys Gly Asp Gly Ile Gly 
    610                 615                 620                 


Pro Thr Arg Gln Pro Pro Ser Gln Gly Leu Gly Tyr Pro Lys Tyr Gln 
625                 630                 635                 640 


Lys Ser Leu Pro Pro Arg Phe Gln Arg Gln Gln Gln Glu Gln Leu Leu 
                645                 650                 655     


Lys Gln Gln Gln Gln His Gln Trp Gln Gln His Gln Gln Gly Ser Ala 
            660                 665                 670         


Pro Pro Thr Pro Val Pro Pro Ser Pro Pro Gln Pro Val Thr Leu Gly 
        675                 680                 685             


Ala Val Pro Ala Pro Gln Ala Pro Pro Pro Pro Pro Lys Ala Leu Tyr 
    690                 695                 700                 


Pro Gly Ala Leu Gly Arg Pro Pro Pro Met Pro Pro Met Asn Phe Asp 
705                 710                 715                 720 


Pro Arg Trp Met Met Ile Pro Pro Tyr Val Asp Pro Arg Leu Leu Gln 
                725                 730                 735     


Gly Arg Pro Pro Leu Asp Phe Tyr Pro Pro Gly Val His Pro Ser Gly 
            740                 745                 750         


Leu Val Pro Arg Glu Arg Ser Asp Ser Gly Gly Ser Ser Ser Glu Pro 
        755                 760                 765             


Phe Asp Arg His Ala Pro Ala Met Leu Arg Glu Arg Gly Thr Pro Pro 
    770                 775                 780                 


Val Asp Pro Lys Leu Ala Trp Val Gly Asp Val Phe Thr Ala Thr Pro 
785                 790                 795                 800 


Ala Glu Pro Arg Pro Leu Thr Ser Pro Leu Arg Gln Ala Ala Asp Glu 
                805                 810                 815     


Asp Asp Lys Gly Met Arg Ser Glu Thr Pro Pro Val Pro Pro Pro Pro 
            820                 825                 830         


Pro Tyr Leu Ala Ser Tyr Pro Gly Phe Pro Glu Asn Gly Ala Pro Gly 
        835                 840                 845             


Pro Pro Ile Ser Arg Phe Pro Leu Glu Glu Pro Gly Pro Arg Pro Leu 
    850                 855                 860                 


Pro Trp Pro Pro Gly Ser Asp Glu Val Ala Lys Ile Gln Thr Pro Pro 
865                 870                 875                 880 


Pro Lys Lys Glu Pro Pro Lys Glu Glu Thr Ala Gln Leu Thr Gly Pro 
                885                 890                 895     


Glu Ala Gly Arg Lys Pro Ala Arg Gly Val Gly Ser Gly Gly Gln Gly 
            900                 905                 910         


Pro Pro Pro Pro Arg Arg Glu Ser Arg Thr Glu Thr Arg Trp Gly Pro 
        915                 920                 925             


Arg Pro Gly Ser Ser Arg Arg Gly Ile Pro Pro Glu Glu Pro Gly Ala 
    930                 935                 940                 


Pro Pro Arg Arg Ala Gly Pro Ile Lys Lys Pro Pro Pro Pro Thr Lys 
945                 950                 955                 960 


Val Glu Glu Leu Pro Pro Lys Pro Leu Glu Gln Gly Asp Glu Thr Pro 
                965                 970                 975     


Lys Pro Pro Lys Pro Asp Pro Leu Lys Ile Thr Lys Gly Lys Leu Gly 
            980                 985                 990         


Gly Pro Lys Glu Thr Pro Pro Asn  Gly Asn Leu Ser Pro  Ala Pro Arg 
        995                 1000                 1005             


Leu Arg  Arg Asp Tyr Ser Tyr  Glu Arg Val Gly Pro  Thr Ser Cys 
    1010                 1015                 1020             


Arg Gly  Arg Gly Arg Gly Glu  Tyr Phe Ala Arg Gly  Arg Gly Phe 
    1025                 1030                 1035             


Arg Gly  Thr Tyr Gly Gly Arg  Gly Arg Gly Ala Arg  Ser Arg Glu 
    1040                 1045                 1050             


Phe Arg  Ser Tyr Arg Glu Phe  Arg Gly Asp Asp Gly  Arg Gly Gly 
    1055                 1060                 1065             


Gly Thr  Gly Gly Pro Asn His  Pro Pro Ala Pro Arg  Gly Arg Thr 
    1070                 1075                 1080             


Ala Ser  Glu Thr Arg Ser Glu  Gly Ser Glu Tyr Glu  Glu Ile Pro 
    1085                 1090                 1095             


Lys Arg  Arg Arg Gln Arg Gly  Ser Glu Thr Gly Ser  Glu Thr His 
    1100                 1105                 1110             


Glu Ser  Asp Leu Ala Pro Ser  Asp Lys Glu Ala Pro  Thr Pro Lys 
    1115                 1120                 1125             


Glu Gly  Thr Leu Thr Gln Val  Pro Leu Ala Pro Pro  Pro Pro Gly 
    1130                 1135                 1140             


Ala Pro  Pro Ser Pro Ala Pro  Ala Arg Phe Thr Ala  Arg Gly Gly 
    1145                 1150                 1155             


Arg Val  Phe Thr Pro Arg Gly  Val Pro Ser Arg Arg  Gly Arg Gly 
    1160                 1165                 1170             


Gly Gly  Arg Pro Pro Pro Gln  Val Cys Pro Gly Trp  Ser Pro Pro 
    1175                 1180                 1185             


Ala Lys  Ser Leu Ala Pro Lys  Lys Pro Pro Thr Gly  Pro Leu Pro 
    1190                 1195                 1200             


Pro Ser  Lys Glu Pro Leu Lys  Glu Lys Leu Ile Pro  Gly Pro Leu 
    1205                 1210                 1215             


Ser Pro  Val Ala Arg Gly Gly  Ser Asn Gly Gly Ser  Asn Val Gly 
    1220                 1225                 1230             


Met Glu  Asp Gly Glu Arg Pro  Arg Arg Arg Arg His  Gly Arg Ala 
    1235                 1240                 1245             


Gln Gln  Gln Asp Lys Pro Pro  Arg Phe Arg Arg Leu  Lys Gln Glu 
    1250                 1255                 1260             


Arg Glu  Asn Ala Ala Arg Gly  Ser Glu Gly Lys Pro  Ser Leu Thr 
    1265                 1270                 1275             


Leu Pro  Ala Ser Ala Pro Ala  Pro Glu Glu Ala Leu  Thr Thr Val 
    1280                 1285                 1290             


Thr Val  Ala Pro Ala Pro Arg  Arg Ala Ala Ala Lys  Ser Pro Asp 
    1295                 1300                 1305             


Leu Ser  Asn Gln Asn Ser Asp  Gln Ala Asn Glu Glu  Trp Glu Thr 
    1310                 1315                 1320             


Ala Ser  Glu Ser Ser Asp Phe  Thr Ser Glu Arg Arg  Gly Asp Lys 
    1325                 1330                 1335             


Glu Ala  Pro Pro Pro Val Leu  Leu Thr Pro Lys Ala  Val Gly Thr 
    1340                 1345                 1350             


Pro Gly  Gly Gly Gly Gly Gly  Ala Val Pro Gly Ile  Ser Ala Met 
    1355                 1360                 1365             


Ser Arg  Gly Asp Leu Ser Gln  Arg Ala Lys Asp Leu  Ser Lys Arg 
    1370                 1375                 1380             


Ser Phe  Ser Ser Gln Arg Pro  Gly Met Glu Arg Gln  Asn Arg Arg 
    1385                 1390                 1395             


Pro Gly  Pro Gly Gly Lys Ala  Gly Ser Ser Gly Ser  Ser Ser Gly 
    1400                 1405                 1410             


Gly Gly  Gly Gly Gly Pro Gly  Gly Arg Thr Gly Pro  Gly Arg Gly 
    1415                 1420                 1425             


Asp Lys  Arg Ser Trp Pro Ser  Pro Lys Asn Arg Ser  Arg Pro Pro 
    1430                 1435                 1440             


Glu Glu  Arg Pro Pro Gly Leu  Pro Leu Pro Pro Pro  Pro Pro Ser 
    1445                 1450                 1455             


Ser Ser  Ala Val Phe Arg Leu  Asp Gln Val Ile His  Ser Asn Pro 
    1460                 1465                 1470             


Ala Gly  Ile Gln Gln Ala Leu  Ala Gln Leu Ser Ser  Arg Gln Gly 
    1475                 1480                 1485             


Ser Val  Thr Ala Pro Gly Gly  His Pro Arg His Lys  Pro Gly Pro 
    1490                 1495                 1500             


Pro Gln  Ala Pro Gln Gly Pro  Ser Pro Arg Pro Pro  Thr Arg Tyr 
    1505                 1510                 1515             


Glu Pro  Gln Arg Val Asn Ser  Gly Leu Ser Ser Asp  Pro His Phe 
    1520                 1525                 1530             


Glu Glu  Pro Gly Pro Met Val  Arg Gly Val Gly Gly  Thr Pro Arg 
    1535                 1540                 1545             


Asp Ser  Ala Gly Val Ser Pro  Phe Pro Pro Lys Arg  Arg Glu Arg 
    1550                 1555                 1560             


Pro Pro  Arg Lys Pro Glu Leu  Leu Gln Glu Glu Ser  Leu Pro Pro 
    1565                 1570                 1575             


Pro His  Ser Ser Gly Phe Leu  Gly Ser Lys Pro Glu  Gly Pro Gly 
    1580                 1585                 1590             


Pro Gln  Ala Glu Ser Arg Asp  Thr Gly Thr Glu Ala  Leu Thr Pro 
    1595                 1600                 1605             


His Ile  Trp Asn Arg Leu His  Thr Ala Thr Ser Arg  Lys Ser Tyr 
    1610                 1615                 1620             


Arg Pro  Ser Ser Met Glu Pro  Trp Met Glu Pro Leu  Ser Pro Phe 
    1625                 1630                 1635             


Glu Asp  Val Ala Gly Thr Glu  Met Ser Gln Ser Asp  Ser Gly Val 
    1640                 1645                 1650             


Asp Leu  Ser Gly Asp Ser Gln  Val Ser Ser Gly Pro  Cys Ser Gln 
    1655                 1660                 1665             


Arg Ser  Ser Pro Asp Gly Gly  Leu Lys Gly Ala Ala  Glu Gly Pro 
    1670                 1675                 1680             


Pro Lys  Arg Pro Gly Gly Ser  Ser Pro Leu Asn Ala  Val Pro Cys 
    1685                 1690                 1695             


Glu Gly  Pro Pro Gly Ser Glu  Pro Pro Arg Arg Pro  Pro Pro Ala 
    1700                 1705                 1710             


Pro His  Asp Gly Asp Arg Lys  Glu Leu Pro Arg Glu  Gln Pro Leu 
    1715                 1720                 1725             


Pro Pro  Gly Pro Ile Gly Thr  Glu Arg Ser Gln His  Thr Asp Arg 
    1730                 1735                 1740             


Gly Thr  Glu Pro Gly Pro Ile  Arg Pro Ser His Arg  Pro Gly Pro 
    1745                 1750                 1755             


Pro Val  Gln Phe Gly Thr Ser  Asp Lys Asp Ser Asp  Leu Arg Leu 
    1760                 1765                 1770             


Val Val  Gly Asp Ser Leu Lys  Ala Glu Lys Glu Leu  Thr Ala Ser 
    1775                 1780                 1785             


Val Thr  Glu Ala Ile Pro Val  Ser Arg Asp Trp Glu  Leu Leu Pro 
    1790                 1795                 1800             


Ser Ala  Ala Ala Ser Ala Glu  Pro Gln Ser Lys Asn  Leu Asp Ser 
    1805                 1810                 1815             


Gly His  Cys Val Pro Glu Pro  Ser Ser Ser Gly Gln  Arg Leu Tyr 
    1820                 1825                 1830             


Pro Glu  Val Phe Tyr Gly Ser  Ala Gly Pro Ser Ser  Ser Gln Ile 
    1835                 1840                 1845             


Ser Gly  Gly Ala Met Asp Ser  Gln Leu His Pro Asn  Ser Gly Gly 
    1850                 1855                 1860             


Phe Arg  Pro Gly Thr Pro Ser  Leu His Pro Tyr Arg  Ser Gln Pro 
    1865                 1870                 1875             


Leu Tyr  Leu Pro Pro Gly Pro  Ala Pro Pro Ser Ala  Leu Leu Ser 
    1880                 1885                 1890             


Gly Val  Ala Leu Lys Gly Gln  Phe Leu Asp Phe Ser  Thr Met Gln 
    1895                 1900                 1905             


Ala Thr  Glu Leu Gly Lys Leu  Pro Ala Gly Gly Val  Leu Tyr Pro 
    1910                 1915                 1920             


Pro Pro  Ser Phe Leu Tyr Ser  Pro Ala Phe Cys Pro  Ser Pro Leu 
    1925                 1930                 1935             


Pro Asp  Thr Ser Leu Leu Gln  Val Arg Gln Asp Leu  Pro Ser Pro 
    1940                 1945                 1950             


Ser Asp  Phe Tyr Ser Thr Pro  Leu Gln Pro Gly Gly  Gln Ser Gly 
    1955                 1960                 1965             


Phe Leu  Pro Ser Gly Ala Pro  Ala Gln Gln Met Leu  Leu Pro Met 
    1970                 1975                 1980             


Val Asp  Ser Gln Leu Pro Val  Val Asn Phe Gly Ser  Leu Pro Pro 
    1985                 1990                 1995             


Ala Pro  Pro Pro Ala Pro Pro  Pro Leu Ser Leu Leu  Pro Val Gly 
    2000                 2005                 2010             


Pro Ala  Leu Gln Pro Pro Ser  Leu Ala Val Arg Pro  Pro Pro Ala 
    2015                 2020                 2025             


Pro Ala  Thr Arg Val Leu Pro  Ser Pro Ala Arg Pro  Phe Pro Ala 
    2030                 2035                 2040             


Ser Leu  Gly Arg Ala Glu Leu  His Pro Val Glu Leu  Lys Pro Phe 
    2045                 2050                 2055             


Gln Asp  Tyr Gln Lys Leu Ser  Ser Asn Leu Gly Gly  Pro Gly Ser 
    2060                 2065                 2070             


Ser Arg  Thr Pro Pro Thr Gly  Arg Ser Phe Ser Gly  Leu Asn Ser 
    2075                 2080                 2085             


Arg Leu  Lys Ala Thr Pro Ser  Thr Tyr Ser Gly Val  Phe Arg Thr 
    2090                 2095                 2100             


Gln Arg  Val Asp Leu Tyr Gln  Gln Ala Ser Pro Pro  Asp Ala Leu 
    2105                 2110                 2115             


Arg Trp  Ile Pro Lys Pro Trp  Glu Arg Thr Gly Leu  Pro Pro Arg 
    2120                 2125                 2130             


Glu Gly  Pro Ser Arg Arg Ala  Glu Glu Pro Gly Ser  Arg Gly Asp 
    2135                 2140                 2145             


Lys Glu  Pro Gly Leu Pro Pro  Pro Arg 
    2150                 2155         


<210>  1540
<211>  3773
<212>  DNA
<213>  Homosapiens

<400>  1540
tagtgcgacg cacgcaggcg tagtacggtc ccccgggcga cagcggtggc ggctcctcgg     60

ggtgctcggc tccctcccac ctaggccggc cccggcccga ctcgccctca gaaactcact    120

gtttggggct gcggactttc tcgtcgtgcc ccacaaaagt aaagcttggg gacctggggg    180

gagccggaag tatcgcttcg agatccccaa atactatcgg ggaaacggaa gtggccgtcg    240

gtggcaggtt tgggggagac cggaagtgac gagacctgtc ggccatggag cctaatgata    300

gtaccagtac cgctgtggag gagcctgaca gcttggaggt gttggtgaag accttggact    360

ctcaaactcg tacctttatt gtgggggccc agatgaatgt aaaagagttt aaggagcaca    420

ttgctgcctc tgtcagcatc ccatctgaaa aacaacggct catttaccag ggacgagttc    480

tgcaagatga taagaagctt caggaataca atgttggggg aaaggttatc cacctggtgg    540

aacgggctcc tcctcagact cacctccctt ctggggcatc ttctgggacg gggtctgcct    600

cagccactca tggtggggga tccccccctg gtactcgggg gcctggggcc tctgttcatg    660

accggaatgc caacagctat gtcatggttg gaaccttcaa tcttcctagt gacggctctg    720

ctgtggatgt tcacatcaac atggaacagg ccccgattca gagtgagccc cgggtacggc    780

tggtgatggc tcagcacatg atcagggata tacagacctt actatcccgg atggagactc    840

tcccctacct tcagtgtcga ggagggcccc aaccgcagca cagtcagccg cccccgcagc    900

caccggctgt gaccccggag ccagtagcct tgagctctca aacatcagaa ccagttgaaa    960

gtgaagcacc tccccgggag cccatggagg cagaagaagt ggaggagcgt gccccagccc   1020

agaacccgga gctcactcct ggcccagccc cagcgggccc aacacctgcc ccggaaacaa   1080

atgcacccaa ccatccttcc cctgcggagt atgtcgaggt gctccaggag ctacagcggc   1140

tggagagtcg cctccagccc ttcttgcagc gctactacga ggttctgggt gctgctgcca   1200

ccacggacta caataacaat cacgagggcc gggaggagga tcagcggttg atcaacttgg   1260

taggggagag cctgcgactg ctgggcaaca cctttgttgc actgtctgac ctgcgctgca   1320

atctggcctg cacgccccca cgacacctgc atgtggtccg gcctatgtct cactacacca   1380

cccccatggt gctccagcag gcagccattc ccatacagat caatgtggga accactgtga   1440

ccatgacagg aaatgggact cggccccccc caactcccaa tgcagaggca cctccccctg   1500

gtcctgggca ggcctcatcc gtggctccgt cttctaccaa tgtcgagtcc tcagctgagg   1560

gggctccccc gccaggtcca gctcccccgc cagccaccag ccacccgagg gtcatccgga   1620

tttcccacca gagtgtggaa cccgtggtca tgatgcacat gaacattcaa gattctggca   1680

cacagcctgg tggtgttccg agtgctccca ctggccccct gggaccccct ggtcatggcc   1740

aaaccctggg acagcaggtg ccaggcttcc caacagctcc aacccgggtg gtgattgccc   1800

ggcccactcc tccacaggct cggccttccc atcctggagg gcccccagtc tctgggacac   1860

tgcagggcgc cggtctgggt accaatgcct cgttggccca gatggtgagc ggccttgtgg   1920

ggcagcttct tatgcagcca gtccttgtgg ctcaggggac cccaggtatg gctccaccgc   1980

cagcccctgc cactgcttct gccagtgctg gcaccaccaa cacagctacc acagctggcc   2040

ccgctcctgg ggggcctgcc cagcctccac ccacccctca accctccatg gctgatcttc   2100

agttctctca gcttctgggg aacctgctag ggcctgcagg gccaggggct ggagggcctg   2160

gtgtggcttc tcccaccatc actgtggcga tgcctggtgt ccctgccttt ctccaaggca   2220

tgactgactt cttgcaggca acacagacag cccctccacc acccccacct cctccacccc   2280

caccacctgc cccagagcag cagaccatgc ccccaccagg ctccccttct ggtggcgcag   2340

ggagtcctgg aggcctgggt cttgagagcc tgtcaccgga gttttttacc tcagtggtgc   2400

agggtgtgct cagctccctg ctgggctccc tgggggctcg ggctggcagc agtgaaagta   2460

ttgctgcctt catacaacgc ctcagtggat ccagcaacat ctttgagcct ggagctgatg   2520

gggcccttgg attctttggg gccttgcttt ctcttctgtg ccagaacttc tctatggtgg   2580

acgtagtgat gcttctccat gggcatttcc agccactaca acggctccag ccccagctgc   2640

gatccttctt ccaccagcac tacctgggtg gtcaggagcc cacacccagt aacatccgga   2700

tggcaaccca cacattgatc acggggctag aagagtatgt gcgggagagt ttttccttgg   2760

tgcaggttca gccaggtgtg gacatcatcc ggacaaacct ggaatttctc caagagcagt   2820

ttaatagcat tgctgcgcat gtgctgcatt gcacagatag tggatttggg gcccggttgc   2880

tggagttgtg taaccaaggc ctgtttgaat gcctggccct aaacctgcac tgcttggggg   2940

gacagcagat ggagcttgct gctgttatca atggccgaat tcgtcgtatg tctcgtgggg   3000

tgaatccctc cttggtgagc tggctgacca ctatgatggg actgaggctt caggtggtac   3060

tggagcacat gcctgtaggc cctgatgcca ttctcagata cgttcgcagg gttggtgatc   3120

ccccccagcc acttcctgag gagccaatgg aagttcaggg agcagaaaga gcttcccctg   3180

agcctcagcg ggagaatgct tccccagccc ctggaacaac agcagaagag gccatgtccc   3240

gaggtccacc tcctgctcct gaggggggct cccgggatga acaggatgga gcttcagctg   3300

agacagaacc ttgggcagct gcagtccccc cagaatgggt ccctattatc cagcaggaca   3360

ttcagagcca gcggaaggtg aaaccgcagc cccctctgag tgatgcctac ctcagtggta   3420

tgcctgccaa gagacgcaag acgatgcagg gtgagggccc ccagctgctt ctctcagagg   3480

ctgtgagccg ggcagctaag gcagccggag ctcggcccct gacgagcccc gagagcctga   3540

gccgggacct ggaggcacca gaggttcagg agagctacag gcagcagctc cggtctgata   3600

tacaaaaacg actgcaggaa gaccccaact acagtcccca gcgcttcccc aatgcccagc   3660

gggcctttgc tgatgatcct tagctctttg ctctatggcc cttcctcatc aggggaccgt   3720

ttcccccctc ttccttcaca gtatttaaga aataaaagtc ggatttttct ggc          3773


<210>  1541
<211>  1132
<212>  PRT
<213>  Homosapiens

<400>  1541

Met Glu Pro Asn Asp Ser Thr Ser Thr Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Thr Leu Asp Ser Gln Thr Arg Thr Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Thr His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Thr Gly Ser Ala Ser Ala Thr His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Thr Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Thr Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Thr Leu Leu Ser Arg Met Glu Thr Leu Pro Tyr Leu Gln Cys Arg 
            180                 185                 190         


Gly Gly Pro Gln Pro Gln His Ser Gln Pro Pro Pro Gln Pro Pro Ala 
        195                 200                 205             


Val Thr Pro Glu Pro Val Ala Leu Ser Ser Gln Thr Ser Glu Pro Val 
    210                 215                 220                 


Glu Ser Glu Ala Pro Pro Arg Glu Pro Met Glu Ala Glu Glu Val Glu 
225                 230                 235                 240 


Glu Arg Ala Pro Ala Gln Asn Pro Glu Leu Thr Pro Gly Pro Ala Pro 
                245                 250                 255     


Ala Gly Pro Thr Pro Ala Pro Glu Thr Asn Ala Pro Asn His Pro Ser 
            260                 265                 270         


Pro Ala Glu Tyr Val Glu Val Leu Gln Glu Leu Gln Arg Leu Glu Ser 
        275                 280                 285             


Arg Leu Gln Pro Phe Leu Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala 
    290                 295                 300                 


Ala Thr Thr Asp Tyr Asn Asn Asn His Glu Gly Arg Glu Glu Asp Gln 
305                 310                 315                 320 


Arg Leu Ile Asn Leu Val Gly Glu Ser Leu Arg Leu Leu Gly Asn Thr 
                325                 330                 335     


Phe Val Ala Leu Ser Asp Leu Arg Cys Asn Leu Ala Cys Thr Pro Pro 
            340                 345                 350         


Arg His Leu His Val Val Arg Pro Met Ser His Tyr Thr Thr Pro Met 
        355                 360                 365             


Val Leu Gln Gln Ala Ala Ile Pro Ile Gln Ile Asn Val Gly Thr Thr 
    370                 375                 380                 


Val Thr Met Thr Gly Asn Gly Thr Arg Pro Pro Pro Thr Pro Asn Ala 
385                 390                 395                 400 


Glu Ala Pro Pro Pro Gly Pro Gly Gln Ala Ser Ser Val Ala Pro Ser 
                405                 410                 415     


Ser Thr Asn Val Glu Ser Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro 
            420                 425                 430         


Ala Pro Pro Pro Ala Thr Ser His Pro Arg Val Ile Arg Ile Ser His 
        435                 440                 445             


Gln Ser Val Glu Pro Val Val Met Met His Met Asn Ile Gln Asp Ser 
    450                 455                 460                 


Gly Thr Gln Pro Gly Gly Val Pro Ser Ala Pro Thr Gly Pro Leu Gly 
465                 470                 475                 480 


Pro Pro Gly His Gly Gln Thr Leu Gly Gln Gln Val Pro Gly Phe Pro 
                485                 490                 495     


Thr Ala Pro Thr Arg Val Val Ile Ala Arg Pro Thr Pro Pro Gln Ala 
            500                 505                 510         


Arg Pro Ser His Pro Gly Gly Pro Pro Val Ser Gly Thr Leu Gln Gly 
        515                 520                 525             


Ala Gly Leu Gly Thr Asn Ala Ser Leu Ala Gln Met Val Ser Gly Leu 
    530                 535                 540                 


Val Gly Gln Leu Leu Met Gln Pro Val Leu Val Ala Gln Gly Thr Pro 
545                 550                 555                 560 


Gly Met Ala Pro Pro Pro Ala Pro Ala Thr Ala Ser Ala Ser Ala Gly 
                565                 570                 575     


Thr Thr Asn Thr Ala Thr Thr Ala Gly Pro Ala Pro Gly Gly Pro Ala 
            580                 585                 590         


Gln Pro Pro Pro Thr Pro Gln Pro Ser Met Ala Asp Leu Gln Phe Ser 
        595                 600                 605             


Gln Leu Leu Gly Asn Leu Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly 
    610                 615                 620                 


Pro Gly Val Ala Ser Pro Thr Ile Thr Val Ala Met Pro Gly Val Pro 
625                 630                 635                 640 


Ala Phe Leu Gln Gly Met Thr Asp Phe Leu Gln Ala Thr Gln Thr Ala 
                645                 650                 655     


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln 
            660                 665                 670         


Gln Thr Met Pro Pro Pro Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro 
        675                 680                 685             


Gly Gly Leu Gly Leu Glu Ser Leu Ser Pro Glu Phe Phe Thr Ser Val 
    690                 695                 700                 


Val Gln Gly Val Leu Ser Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala 
705                 710                 715                 720 


Gly Ser Ser Glu Ser Ile Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser 
                725                 730                 735     


Ser Asn Ile Phe Glu Pro Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly 
            740                 745                 750         


Ala Leu Leu Ser Leu Leu Cys Gln Asn Phe Ser Met Val Asp Val Val 
        755                 760                 765             


Met Leu Leu His Gly His Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln 
    770                 775                 780                 


Leu Arg Ser Phe Phe His Gln His Tyr Leu Gly Gly Gln Glu Pro Thr 
785                 790                 795                 800 


Pro Ser Asn Ile Arg Met Ala Thr His Thr Leu Ile Thr Gly Leu Glu 
                805                 810                 815     


Glu Tyr Val Arg Glu Ser Phe Ser Leu Val Gln Val Gln Pro Gly Val 
            820                 825                 830         


Asp Ile Ile Arg Thr Asn Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser 
        835                 840                 845             


Ile Ala Ala His Val Leu His Cys Thr Asp Ser Gly Phe Gly Ala Arg 
    850                 855                 860                 


Leu Leu Glu Leu Cys Asn Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn 
865                 870                 875                 880 


Leu His Cys Leu Gly Gly Gln Gln Met Glu Leu Ala Ala Val Ile Asn 
                885                 890                 895     


Gly Arg Ile Arg Arg Met Ser Arg Gly Val Asn Pro Ser Leu Val Ser 
            900                 905                 910         


Trp Leu Thr Thr Met Met Gly Leu Arg Leu Gln Val Val Leu Glu His 
        915                 920                 925             


Met Pro Val Gly Pro Asp Ala Ile Leu Arg Tyr Val Arg Arg Val Gly 
    930                 935                 940                 


Asp Pro Pro Gln Pro Leu Pro Glu Glu Pro Met Glu Val Gln Gly Ala 
945                 950                 955                 960 


Glu Arg Ala Ser Pro Glu Pro Gln Arg Glu Asn Ala Ser Pro Ala Pro 
                965                 970                 975     


Gly Thr Thr Ala Glu Glu Ala Met Ser Arg Gly Pro Pro Pro Ala Pro 
            980                 985                 990         


Glu Gly Gly Ser Arg Asp Glu Gln  Asp Gly Ala Ser Ala  Glu Thr Glu 
        995                 1000                 1005             


Pro Trp  Ala Ala Ala Val Pro  Pro Glu Trp Val Pro  Ile Ile Gln 
    1010                 1015                 1020             


Gln Asp  Ile Gln Ser Gln Arg  Lys Val Lys Pro Gln  Pro Pro Leu 
    1025                 1030                 1035             


Ser Asp  Ala Tyr Leu Ser Gly  Met Pro Ala Lys Arg  Arg Lys Thr 
    1040                 1045                 1050             


Met Gln  Gly Glu Gly Pro Gln  Leu Leu Leu Ser Glu  Ala Val Ser 
    1055                 1060                 1065             


Arg Ala  Ala Lys Ala Ala Gly  Ala Arg Pro Leu Thr  Ser Pro Glu 
    1070                 1075                 1080             


Ser Leu  Ser Arg Asp Leu Glu  Ala Pro Glu Val Gln  Glu Ser Tyr 
    1085                 1090                 1095             


Arg Gln  Gln Leu Arg Ser Asp  Ile Gln Lys Arg Leu  Gln Glu Asp 
    1100                 1105                 1110             


Pro Asn  Tyr Ser Pro Gln Arg  Phe Pro Asn Ala Gln  Arg Ala Phe 
    1115                 1120                 1125             


Ala Asp  Asp Pro 
    1130         


<210>  1542
<211>  3754
<212>  DNA
<213>  Homosapiens

<400>  1542
tagtgcgacg cacgcaggcg tagtacggtc ccccgggcga cagcggtggc ggctcctcgg     60

ggtgctcggc tccctcccac ctaggccggc cccggcccga ctcgccctca gaaactcact    120

gtttggggct gcggactttc tcgtcgtgcc ccacaaaagt aaagcttggg gacctggggg    180

gagccggaag tatcgcttcg agatccccaa atactatcgg ggaaacggaa gtggccgtcg    240

gtggcagaga cctgtcggcc atggagccta atgatagtac cagtaccgct gtggaggagc    300

ctgacagctt ggaggtgttg gtgaagacct tggactctca aactcgtacc tttattgtgg    360

gggcccagat gaatgtaaaa gagtttaagg agcacattgc tgcctctgtc agcatcccat    420

ctgaaaaaca acggctcatt taccagggac gagttctgca agatgataag aagcttcagg    480

aatacaatgt tgggggaaag gttatccacc tggtggaacg ggctcctcct cagactcacc    540

tcccttctgg ggcatcttct gggacggggt ctgcctcagc cactcatggt gggggatccc    600

cccctggtac tcgggggcct ggggcctctg ttcatgaccg gaatgccaac agctatgtca    660

tggttggaac cttcaatctt cctagtgacg gctctgctgt ggatgttcac atcaacatgg    720

aacaggcccc gattcagagt gagccccggg tacggctggt gatggctcag cacatgatca    780

gggatataca gaccttacta tcccggatgg agtgtcgagg agggccccaa ccgcagcaca    840

gtcagccgcc cccgcagcca ccggctgtga ccccggagcc agtagccttg agctctcaaa    900

catcagaacc agttgaaagt gaagcacctc cccgggagcc catggaggca gaagaagtgg    960

aggagcgtgc cccagcccag aacccggagc tcactcctgg cccagcccca gcgggcccaa   1020

cacctgcccc ggaaacaaat gcacccaacc atccttcccc tgcggagtat gtcgaggtgc   1080

tccaggagct acagcggctg gagagtcgcc tccagccctt cttgcagcgc tactacgagg   1140

ttctgggtgc tgctgccacc acggactaca ataacaatca cgagggccgg gaggaggatc   1200

agcggttgat caacttggta ggggagagcc tgcgactgct gggcaacacc tttgttgcac   1260

tgtctgacct gcgctgcaat ctggcctgca cgcccccacg acacctgcat gtggtccggc   1320

ctatgtctca ctacaccacc cccatggtgc tccagcaggc agccattccc atacagatca   1380

atgtgggaac cactgtgacc atgacaggaa atgggactcg gcccccccca actcccaatg   1440

cagaggcacc tccccctggt cctgggcagg cctcatccgt ggctccgtct tctaccaatg   1500

tcgagtcctc agctgagggg gctcccccgc caggtccagc tcccccgcca gccaccagcc   1560

acccgagggt catccggatt tcccaccaga gtgtggaacc cgtggtcatg atgcacatga   1620

acattcaaga ttctggcaca cagcctggtg gtgttccgag tgctcccact ggccccctgg   1680

gaccccctgg tcatggccaa accctgggac agcaggtgcc aggcttccca acagctccaa   1740

cccgggtggt gattgcccgg cccactcctc cacaggctcg gccttcccat cctggagggc   1800

ccccagtctc tgggacactg cagggcgccg gtctgggtac caatgcctcg ttggcccaga   1860

tggtgagcgg ccttgtgggg cagcttctta tgcagccagt ccttgtggct caggggaccc   1920

caggtatggc tccaccgcca gcccctgcca ctgcttctgc cagtgctggc accaccaaca   1980

cagctaccac agctggcccc gctcctgggg ggcctgccca gcctccaccc acccctcaac   2040

cctccatggc tgatcttcag ttctctcagc ttctggggaa cctgctaggg cctgcagggc   2100

caggggctgg agggtctggt gtggcttctc ccaccatcac tgtggcgatg cctggtgtcc   2160

ctgcctttct ccaaggcatg actgacttct tgcaggcaac acagacagcc cctccaccac   2220

ccccacctcc tccaccccca ccacctgccc cagagcagca gaccatgccc ccaccaggct   2280

ccccttctgg tggcgcaggg agtcctggag gcctgggtct tgagagcctg tcaccggagt   2340

tttttacctc agtggtgcag ggtgtgctca gctccctgct gggctccctg ggggctcggg   2400

ctggcagcag tgaaagtatt gctgccttca tacaacgcct cagtggatcc agcaacatct   2460

ttgagcctgg agctgatggg gcccttggat tctttggggc cttgctttct cttctgtgcc   2520

agaacttctc tatggtggac gtagtgatgc ttctccatgg gcatttccag ccactacaac   2580

ggctccagcc ccagctgcga tccttcttcc accagcacta cctgggtggt caggagccca   2640

cacccagtaa catccggatg gcaacccaca cattgatcac ggggctagaa gagtatgtgc   2700

gggagagttt ttccttggtg caggttcagc caggtgtgga catcatccgg acaaacctgg   2760

aatttctcca agagcagttt aatagcattg ctgcgcatgt gctgcattgc acagatagtg   2820

gatttggggc ccggttgctg gagttgtgta accaaggcct gtttgaatgc ctggccctaa   2880

acctgcactg cttgggggga cagcagatgg agcttgctgc tgttatcaat ggccgaattc   2940

gtcgtatgtc tcgtggggtg aatccctcct tggtgagctg gctgaccact atgatgggac   3000

tgaggcttca ggtggtactg gagcacatgc ctgtaggccc tgatgccatt ctcagatacg   3060

ttcgcagggt tggtgatccc ccccagccac ttcctgagga gccaatggaa gttcagggag   3120

cagaaagagc ttcccctgag cctcagcggg agaatgcttc cccagcccct ggaacaacag   3180

cagaagaggc catgtcccga ggtccacctc ctgctcctga ggggggctcc cgggatgaac   3240

aggatggagc ttcagctgag acagaacctt gggcagctgc agtcccccca gaatgggtcc   3300

ctattatcca gcaggacatt cagagccagc ggaaggtgaa accgcagccc cctctgagtg   3360

atgcctacct cagtggtatg cctgccaaga gacgcaagac gatgcagggt gagggccccc   3420

agctgcttct ctcagaggct gtgagccggg cagctaaggc agccggagct cggcccctga   3480

cgagccccga gagcctgagc cgggacctgg aggcaccaga ggttcaggag agctacaggc   3540

agcagctccg gtctgatata caaaaacgac tgcaggaaga ccccaactac agtccccagc   3600

gcttccccaa tgcccagcgg gcctttgctg atgatcctta gctctttgct ctatggccct   3660

tcctcatcag gggaccgttt cccccctctt ccttcacagt atttaagaaa taaaagtcgg   3720

atttttctgg caaaaaaaaa aaaaaaaaaa aaaa                               3754


<210>  1543
<211>  1126
<212>  PRT
<213>  Homosapiens

<400>  1543

Met Glu Pro Asn Asp Ser Thr Ser Thr Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Thr Leu Asp Ser Gln Thr Arg Thr Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Thr His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Thr Gly Ser Ala Ser Ala Thr His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Thr Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Thr Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Thr Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Thr Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Thr Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Thr Pro Gly Pro Ala Pro Ala Gly Pro Thr Pro Ala 
                245                 250                 255     


Pro Glu Thr Asn Ala Pro Asn His Pro Ser Pro Ala Glu Tyr Val Glu 
            260                 265                 270         


Val Leu Gln Glu Leu Gln Arg Leu Glu Ser Arg Leu Gln Pro Phe Leu 
        275                 280                 285             


Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala Ala Thr Thr Asp Tyr Asn 
    290                 295                 300                 


Asn Asn His Glu Gly Arg Glu Glu Asp Gln Arg Leu Ile Asn Leu Val 
305                 310                 315                 320 


Gly Glu Ser Leu Arg Leu Leu Gly Asn Thr Phe Val Ala Leu Ser Asp 
                325                 330                 335     


Leu Arg Cys Asn Leu Ala Cys Thr Pro Pro Arg His Leu His Val Val 
            340                 345                 350         


Arg Pro Met Ser His Tyr Thr Thr Pro Met Val Leu Gln Gln Ala Ala 
        355                 360                 365             


Ile Pro Ile Gln Ile Asn Val Gly Thr Thr Val Thr Met Thr Gly Asn 
    370                 375                 380                 


Gly Thr Arg Pro Pro Pro Thr Pro Asn Ala Glu Ala Pro Pro Pro Gly 
385                 390                 395                 400 


Pro Gly Gln Ala Ser Ser Val Ala Pro Ser Ser Thr Asn Val Glu Ser 
                405                 410                 415     


Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala Thr 
            420                 425                 430         


Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val 
        435                 440                 445             


Val Met Met His Met Asn Ile Gln Asp Ser Gly Thr Gln Pro Gly Gly 
    450                 455                 460                 


Val Pro Ser Ala Pro Thr Gly Pro Leu Gly Pro Pro Gly His Gly Gln 
465                 470                 475                 480 


Thr Leu Gly Gln Gln Val Pro Gly Phe Pro Thr Ala Pro Thr Arg Val 
                485                 490                 495     


Val Ile Ala Arg Pro Thr Pro Pro Gln Ala Arg Pro Ser His Pro Gly 
            500                 505                 510         


Gly Pro Pro Val Ser Gly Thr Leu Gln Gly Ala Gly Leu Gly Thr Asn 
        515                 520                 525             


Ala Ser Leu Ala Gln Met Val Ser Gly Leu Val Gly Gln Leu Leu Met 
    530                 535                 540                 


Gln Pro Val Leu Val Ala Gln Gly Thr Pro Gly Met Ala Pro Pro Pro 
545                 550                 555                 560 


Ala Pro Ala Thr Ala Ser Ala Ser Ala Gly Thr Thr Asn Thr Ala Thr 
                565                 570                 575     


Thr Ala Gly Pro Ala Pro Gly Gly Pro Ala Gln Pro Pro Pro Thr Pro 
            580                 585                 590         


Gln Pro Ser Met Ala Asp Leu Gln Phe Ser Gln Leu Leu Gly Asn Leu 
        595                 600                 605             


Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly Ser Gly Val Ala Ser Pro 
    610                 615                 620                 


Thr Ile Thr Val Ala Met Pro Gly Val Pro Ala Phe Leu Gln Gly Met 
625                 630                 635                 640 


Thr Asp Phe Leu Gln Ala Thr Gln Thr Ala Pro Pro Pro Pro Pro Pro 
                645                 650                 655     


Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln Gln Thr Met Pro Pro Pro 
            660                 665                 670         


Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro Gly Gly Leu Gly Leu Glu 
        675                 680                 685             


Ser Leu Ser Pro Glu Phe Phe Thr Ser Val Val Gln Gly Val Leu Ser 
    690                 695                 700                 


Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala Gly Ser Ser Glu Ser Ile 
705                 710                 715                 720 


Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser Ser Asn Ile Phe Glu Pro 
                725                 730                 735     


Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly Ala Leu Leu Ser Leu Leu 
            740                 745                 750         


Cys Gln Asn Phe Ser Met Val Asp Val Val Met Leu Leu His Gly His 
        755                 760                 765             


Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln Leu Arg Ser Phe Phe His 
    770                 775                 780                 


Gln His Tyr Leu Gly Gly Gln Glu Pro Thr Pro Ser Asn Ile Arg Met 
785                 790                 795                 800 


Ala Thr His Thr Leu Ile Thr Gly Leu Glu Glu Tyr Val Arg Glu Ser 
                805                 810                 815     


Phe Ser Leu Val Gln Val Gln Pro Gly Val Asp Ile Ile Arg Thr Asn 
            820                 825                 830         


Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser Ile Ala Ala His Val Leu 
        835                 840                 845             


His Cys Thr Asp Ser Gly Phe Gly Ala Arg Leu Leu Glu Leu Cys Asn 
    850                 855                 860                 


Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn Leu His Cys Leu Gly Gly 
865                 870                 875                 880 


Gln Gln Met Glu Leu Ala Ala Val Ile Asn Gly Arg Ile Arg Arg Met 
                885                 890                 895     


Ser Arg Gly Val Asn Pro Ser Leu Val Ser Trp Leu Thr Thr Met Met 
            900                 905                 910         


Gly Leu Arg Leu Gln Val Val Leu Glu His Met Pro Val Gly Pro Asp 
        915                 920                 925             


Ala Ile Leu Arg Tyr Val Arg Arg Val Gly Asp Pro Pro Gln Pro Leu 
    930                 935                 940                 


Pro Glu Glu Pro Met Glu Val Gln Gly Ala Glu Arg Ala Ser Pro Glu 
945                 950                 955                 960 


Pro Gln Arg Glu Asn Ala Ser Pro Ala Pro Gly Thr Thr Ala Glu Glu 
                965                 970                 975     


Ala Met Ser Arg Gly Pro Pro Pro Ala Pro Glu Gly Gly Ser Arg Asp 
            980                 985                 990         


Glu Gln Asp Gly Ala Ser Ala Glu  Thr Glu Pro Trp Ala  Ala Ala Val 
        995                 1000                 1005             


Pro Pro  Glu Trp Val Pro Ile  Ile Gln Gln Asp Ile  Gln Ser Gln 
    1010                 1015                 1020             


Arg Lys  Val Lys Pro Gln Pro  Pro Leu Ser Asp Ala  Tyr Leu Ser 
    1025                 1030                 1035             


Gly Met  Pro Ala Lys Arg Arg  Lys Thr Met Gln Gly  Glu Gly Pro 
    1040                 1045                 1050             


Gln Leu  Leu Leu Ser Glu Ala  Val Ser Arg Ala Ala  Lys Ala Ala 
    1055                 1060                 1065             


Gly Ala  Arg Pro Leu Thr Ser  Pro Glu Ser Leu Ser  Arg Asp Leu 
    1070                 1075                 1080             


Glu Ala  Pro Glu Val Gln Glu  Ser Tyr Arg Gln Gln  Leu Arg Ser 
    1085                 1090                 1095             


Asp Ile  Gln Lys Arg Leu Gln  Glu Asp Pro Asn Tyr  Ser Pro Gln 
    1100                 1105                 1110             


Arg Phe  Pro Asn Ala Gln Arg  Ala Phe Ala Asp Asp  Pro 
    1115                 1120                 1125     


<210>  1544
<211>  3755
<212>  DNA
<213>  Homosapiens

<400>  1544
tagtgcgacg cacgcaggcg tagtacggtc ccccgggcga cagcggtggc ggctcctcgg     60

ggtgctcggc tccctcccac ctaggccggc cccggcccga ctcgccctca gaaactcact    120

gtttggggct gcggactttc tcgtcgtgcc ccacaaaagt aaagcttggg gacctggggg    180

gagccggaag tatcgcttcg agatccccaa atactatcgg ggaaacggaa gtggccgtcg    240

gtggcaggtt tgggggagac cggaagtgac gagacctgtc ggccatggag cctaatgata    300

gtaccagtac cgctgtggag gagcctgaca gcttggaggt gttggtgaag accttggact    360

ctcaaactcg tacctttatt gtgggggccc agatgaatgt aaaagagttt aaggagcaca    420

ttgctgcctc tgtcagcatc ccatctgaaa aacaacggct catttaccag ggacgagttc    480

tgcaagatga taagaagctt caggaataca atgttggggg aaaggttatc cacctggtgg    540

aacgggctcc tcctcagact cacctccctt ctggggcatc ttctgggacg gggtctgcct    600

cagccactca tggtggggga tccccccctg gtactcgggg gcctggggcc tctgttcatg    660

accggaatgc caacagctat gtcatggttg gaaccttcaa tcttcctagt gacggctctg    720

ctgtggatgt tcacatcaac atggaacagg ccccgattca gagtgagccc cgggtacggc    780

tggtgatggc tcagcacatg atcagggata tacagacctt actatcccgg atggagtgtc    840

gaggagggcc ccaaccgcag cacagtcagc cgcccccgca gccaccggct gtgaccccgg    900

agccagtagc cttgagctct caaacatcag aaccagttga aagtgaagca cctccccggg    960

agcccatgga ggcagaagaa gtggaggagc gtgccccagc ccagaacccg gagctcactc   1020

ctggcccagc cccagcgggc ccaacacctg ccccggaaac aaatgcaccc aaccatcctt   1080

cccctgcgga gtatgtcgag gtgctccagg agctacagcg gctggagagt cgcctccagc   1140

ccttcttgca gcgctactac gaggttctgg gtgctgctgc caccacggac tacaataaca   1200

atcacgaggg ccgggaggag gatcagcggt tgatcaactt ggtaggggag agcctgcgac   1260

tgctgggcaa cacctttgtt gcactgtctg acctgcgctg caatctggcc tgcacgcccc   1320

cacgacacct gcatgtggtc cggcctatgt ctcactacac cacccccatg gtgctccagc   1380

aggcagccat tcccatacag atcaatgtgg gaaccactgt gaccatgaca ggaaatggga   1440

ctcggccccc cccaactccc aatgcagagg cacctccccc tggtcctggg caggcctcat   1500

ccgtggctcc gtcttctacc aatgtcgagt cctcagctga gggggctccc ccgccaggtc   1560

cagctccccc gccagccacc agccacccga gggtcatccg gatttcccac cagagtgtgg   1620

aacccgtggt catgatgcac atgaacattc aagattctgg cacacagcct ggtggtgttc   1680

cgagtgctcc cactggcccc ctgggacccc ctggtcatgg ccaaaccctg ggacagcagg   1740

tgccaggctt cccaacagct ccaacccggg tggtgattgc ccggcccact cctccacagg   1800

ctcggccttc ccatcctgga gggcccccag tctctgggac actgcagggc gccggtctgg   1860

gtaccaatgc ctcgttggcc cagatggtga gcggccttgt ggggcagctt cttatgcagc   1920

cagtccttgt ggctcagggg accccaggta tggctccacc gccagcccct gccactgctt   1980

ctgccagtgc tggcaccacc aacacagcta ccacagctgg ccccgctcct ggggggcctg   2040

cccagcctcc acccacccct caaccctcca tggctgatct tcagttctct cagcttctgg   2100

ggaacctgct agggcctgca gggccagggg ctggagggtc tggtgtggct tctcccacca   2160

tcactgtggc gatgcctggt gtccctgcct ttctccaagg catgactgac ttcttgcagg   2220

caacacagac agcccctcca ccacccccac ctcctccacc cccaccacct gccccagagc   2280

agcagaccat gcccccacca ggctcccctt ctggtggcgc agggagtcct ggaggcctgg   2340

gtcttgagag cctgtcaccg gagtttttta cctcagtggt gcagggtgtg ctcagctccc   2400

tgctgggctc cctgggggct cgggctggca gcagtgaaag tattgctgcc ttcatacaac   2460

gcctcagtgg atccagcaac atctttgagc ctggagctga tggggccctt ggattctttg   2520

gggccttgct ttctcttctg tgccagaact tctctatggt ggacgtagtg atgcttctcc   2580

atgggcattt ccagccacta caacggctcc agccccagct gcgatccttc ttccaccagc   2640

actacctggg tggtcaggag cccacaccca gtaacatccg gatggcaacc cacacattga   2700

tcacggggct agaagagtat gtgcgggaga gtttttcctt ggtgcaggtt cagccaggtg   2760

tggacatcat ccggacaaac ctggaatttc tccaagagca gtttaatagc attgctgcgc   2820

atgtgctgca ttgcacagat agtggatttg gggcccggtt gctggagttg tgtaaccaag   2880

gcctgtttga atgcctggcc ctaaacctgc actgcttggg gggacagcag atggagcttg   2940

ctgctgttat caatggccga attcgtcgta tgtctcgtgg ggtgaatccc tccttggtga   3000

gctggctgac cactatgatg ggactgaggc ttcaggtggt actggagcac atgcctgtag   3060

gccctgatgc cattctcaga tacgttcgca gggttggtga tcccccccag ccacttcctg   3120

aggagccaat ggaagttcag ggagcagaaa gagcttcccc tgagcctcag cgggagaatg   3180

cttccccagc ccctggaaca acagcagaag aggccatgtc ccgaggtcca cctcctgctc   3240

ctgagggggg ctcccgggat gaacaggatg gagcttcagc tgagacagaa ccttgggcag   3300

ctgcagtccc cccagaatgg gtccctatta tccagcagga cattcagagc cagcggaagg   3360

tgaaaccgca gccccctctg agtgatgcct acctcagtgg tatgcctgcc aagagacgca   3420

agacgatgca gggtgagggc ccccagctgc ttctctcaga ggctgtgagc cgggcagcta   3480

aggcagccgg agctcggccc ctgacgagcc ccgagagcct gagccgggac ctggaggcac   3540

cagaggttca ggagagctac aggcagcagc tccggtctga tatacaaaaa cgactgcagg   3600

aagaccccaa ctacagtccc cagcgcttcc ccaatgccca gcgggccttt gctgatgatc   3660

cttagctctt tgctctatgg cccttcctca tcaggggacc gtttcccccc tcttccttca   3720

cagtatttaa gaaataaaag tcggattttt ctggc                              3755


<210>  1545
<211>  1126
<212>  PRT
<213>  Homosapiens

<400>  1545

Met Glu Pro Asn Asp Ser Thr Ser Thr Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Thr Leu Asp Ser Gln Thr Arg Thr Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Thr His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Thr Gly Ser Ala Ser Ala Thr His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Thr Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Thr Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Thr Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Thr Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Thr Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Thr Pro Gly Pro Ala Pro Ala Gly Pro Thr Pro Ala 
                245                 250                 255     


Pro Glu Thr Asn Ala Pro Asn His Pro Ser Pro Ala Glu Tyr Val Glu 
            260                 265                 270         


Val Leu Gln Glu Leu Gln Arg Leu Glu Ser Arg Leu Gln Pro Phe Leu 
        275                 280                 285             


Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala Ala Thr Thr Asp Tyr Asn 
    290                 295                 300                 


Asn Asn His Glu Gly Arg Glu Glu Asp Gln Arg Leu Ile Asn Leu Val 
305                 310                 315                 320 


Gly Glu Ser Leu Arg Leu Leu Gly Asn Thr Phe Val Ala Leu Ser Asp 
                325                 330                 335     


Leu Arg Cys Asn Leu Ala Cys Thr Pro Pro Arg His Leu His Val Val 
            340                 345                 350         


Arg Pro Met Ser His Tyr Thr Thr Pro Met Val Leu Gln Gln Ala Ala 
        355                 360                 365             


Ile Pro Ile Gln Ile Asn Val Gly Thr Thr Val Thr Met Thr Gly Asn 
    370                 375                 380                 


Gly Thr Arg Pro Pro Pro Thr Pro Asn Ala Glu Ala Pro Pro Pro Gly 
385                 390                 395                 400 


Pro Gly Gln Ala Ser Ser Val Ala Pro Ser Ser Thr Asn Val Glu Ser 
                405                 410                 415     


Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala Thr 
            420                 425                 430         


Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val 
        435                 440                 445             


Val Met Met His Met Asn Ile Gln Asp Ser Gly Thr Gln Pro Gly Gly 
    450                 455                 460                 


Val Pro Ser Ala Pro Thr Gly Pro Leu Gly Pro Pro Gly His Gly Gln 
465                 470                 475                 480 


Thr Leu Gly Gln Gln Val Pro Gly Phe Pro Thr Ala Pro Thr Arg Val 
                485                 490                 495     


Val Ile Ala Arg Pro Thr Pro Pro Gln Ala Arg Pro Ser His Pro Gly 
            500                 505                 510         


Gly Pro Pro Val Ser Gly Thr Leu Gln Gly Ala Gly Leu Gly Thr Asn 
        515                 520                 525             


Ala Ser Leu Ala Gln Met Val Ser Gly Leu Val Gly Gln Leu Leu Met 
    530                 535                 540                 


Gln Pro Val Leu Val Ala Gln Gly Thr Pro Gly Met Ala Pro Pro Pro 
545                 550                 555                 560 


Ala Pro Ala Thr Ala Ser Ala Ser Ala Gly Thr Thr Asn Thr Ala Thr 
                565                 570                 575     


Thr Ala Gly Pro Ala Pro Gly Gly Pro Ala Gln Pro Pro Pro Thr Pro 
            580                 585                 590         


Gln Pro Ser Met Ala Asp Leu Gln Phe Ser Gln Leu Leu Gly Asn Leu 
        595                 600                 605             


Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly Ser Gly Val Ala Ser Pro 
    610                 615                 620                 


Thr Ile Thr Val Ala Met Pro Gly Val Pro Ala Phe Leu Gln Gly Met 
625                 630                 635                 640 


Thr Asp Phe Leu Gln Ala Thr Gln Thr Ala Pro Pro Pro Pro Pro Pro 
                645                 650                 655     


Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln Gln Thr Met Pro Pro Pro 
            660                 665                 670         


Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro Gly Gly Leu Gly Leu Glu 
        675                 680                 685             


Ser Leu Ser Pro Glu Phe Phe Thr Ser Val Val Gln Gly Val Leu Ser 
    690                 695                 700                 


Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala Gly Ser Ser Glu Ser Ile 
705                 710                 715                 720 


Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser Ser Asn Ile Phe Glu Pro 
                725                 730                 735     


Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly Ala Leu Leu Ser Leu Leu 
            740                 745                 750         


Cys Gln Asn Phe Ser Met Val Asp Val Val Met Leu Leu His Gly His 
        755                 760                 765             


Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln Leu Arg Ser Phe Phe His 
    770                 775                 780                 


Gln His Tyr Leu Gly Gly Gln Glu Pro Thr Pro Ser Asn Ile Arg Met 
785                 790                 795                 800 


Ala Thr His Thr Leu Ile Thr Gly Leu Glu Glu Tyr Val Arg Glu Ser 
                805                 810                 815     


Phe Ser Leu Val Gln Val Gln Pro Gly Val Asp Ile Ile Arg Thr Asn 
            820                 825                 830         


Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser Ile Ala Ala His Val Leu 
        835                 840                 845             


His Cys Thr Asp Ser Gly Phe Gly Ala Arg Leu Leu Glu Leu Cys Asn 
    850                 855                 860                 


Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn Leu His Cys Leu Gly Gly 
865                 870                 875                 880 


Gln Gln Met Glu Leu Ala Ala Val Ile Asn Gly Arg Ile Arg Arg Met 
                885                 890                 895     


Ser Arg Gly Val Asn Pro Ser Leu Val Ser Trp Leu Thr Thr Met Met 
            900                 905                 910         


Gly Leu Arg Leu Gln Val Val Leu Glu His Met Pro Val Gly Pro Asp 
        915                 920                 925             


Ala Ile Leu Arg Tyr Val Arg Arg Val Gly Asp Pro Pro Gln Pro Leu 
    930                 935                 940                 


Pro Glu Glu Pro Met Glu Val Gln Gly Ala Glu Arg Ala Ser Pro Glu 
945                 950                 955                 960 


Pro Gln Arg Glu Asn Ala Ser Pro Ala Pro Gly Thr Thr Ala Glu Glu 
                965                 970                 975     


Ala Met Ser Arg Gly Pro Pro Pro Ala Pro Glu Gly Gly Ser Arg Asp 
            980                 985                 990         


Glu Gln Asp Gly Ala Ser Ala Glu  Thr Glu Pro Trp Ala  Ala Ala Val 
        995                 1000                 1005             


Pro Pro  Glu Trp Val Pro Ile  Ile Gln Gln Asp Ile  Gln Ser Gln 
    1010                 1015                 1020             


Arg Lys  Val Lys Pro Gln Pro  Pro Leu Ser Asp Ala  Tyr Leu Ser 
    1025                 1030                 1035             


Gly Met  Pro Ala Lys Arg Arg  Lys Thr Met Gln Gly  Glu Gly Pro 
    1040                 1045                 1050             


Gln Leu  Leu Leu Ser Glu Ala  Val Ser Arg Ala Ala  Lys Ala Ala 
    1055                 1060                 1065             


Gly Ala  Arg Pro Leu Thr Ser  Pro Glu Ser Leu Ser  Arg Asp Leu 
    1070                 1075                 1080             


Glu Ala  Pro Glu Val Gln Glu  Ser Tyr Arg Gln Gln  Leu Arg Ser 
    1085                 1090                 1095             


Asp Ile  Gln Lys Arg Leu Gln  Glu Asp Pro Asn Tyr  Ser Pro Gln 
    1100                 1105                 1110             


Arg Phe  Pro Asn Ala Gln Arg  Ala Phe Ala Asp Asp  Pro 
    1115                 1120                 1125     


<210>  1546
<211>  790
<212>  DNA
<213>  Homosapiens

<400>  1546
agagtggact gagcagccag taggggagag agcagttaag gcacacagag caccagctcc     60

ctcctgcctg aagatgttcc accaaatttg ggcagctctg ctctacttct atggtattat    120

ccttaactcc atctaccagt gccctgagca cagtcaactg acaactctgg gcgtggatgg    180

gaaggagttc ccagaggtcc acttgggcca gtggtacttt atcgcagggg cagctcccac    240

caaggaggag ttggcaactt ttgaccctgt ggacaacatt gtcttcaata tggctgctgg    300

ctctgccccg atgcagctcc accttcgtgc taccatccgc atgaaagatg ggctctgtgt    360

gccccggaaa tggatctacc acctgactga agggagcaca gatctcagaa ctgaaggccg    420

ccctgacatg aagactgagc tcttttccag ctcatgccca ggtggaatca tgctgaatga    480

gacaggccag ggttaccagc gctttctcct ctacaatcgc tcaccacatc ctcccgaaaa    540

gtgtgtggag gaattcaagt ccctgacttc ctgcctggac tccaaagcct tcttattgac    600

tcctaggaat caagaggcct gtgagctgtc caataactga cctgtaactt catctaagtc    660

cccagatggg tacaatggga gctgagttgt tggagggaga agctggagac ttccagctcc    720

agctcccact caagataata aagataattt ttcaatcctc aaaaaaaaaa aaaaaaaaaa    780

aaaaaaaaaa                                                           790


<210>  1547
<211>  188
<212>  PRT
<213>  Homosapiens

<400>  1547

Met Phe His Gln Ile Trp Ala Ala Leu Leu Tyr Phe Tyr Gly Ile Ile 
1               5                   10                  15      


Leu Asn Ser Ile Tyr Gln Cys Pro Glu His Ser Gln Leu Thr Thr Leu 
            20                  25                  30          


Gly Val Asp Gly Lys Glu Phe Pro Glu Val His Leu Gly Gln Trp Tyr 
        35                  40                  45              


Phe Ile Ala Gly Ala Ala Pro Thr Lys Glu Glu Leu Ala Thr Phe Asp 
    50                  55                  60                  


Pro Val Asp Asn Ile Val Phe Asn Met Ala Ala Gly Ser Ala Pro Met 
65                  70                  75                  80  


Gln Leu His Leu Arg Ala Thr Ile Arg Met Lys Asp Gly Leu Cys Val 
                85                  90                  95      


Pro Arg Lys Trp Ile Tyr His Leu Thr Glu Gly Ser Thr Asp Leu Arg 
            100                 105                 110         


Thr Glu Gly Arg Pro Asp Met Lys Thr Glu Leu Phe Ser Ser Ser Cys 
        115                 120                 125             


Pro Gly Gly Ile Met Leu Asn Glu Thr Gly Gln Gly Tyr Gln Arg Phe 
    130                 135                 140                 


Leu Leu Tyr Asn Arg Ser Pro His Pro Pro Glu Lys Cys Val Glu Glu 
145                 150                 155                 160 


Phe Lys Ser Leu Thr Ser Cys Leu Asp Ser Lys Ala Phe Leu Leu Thr 
                165                 170                 175     


Pro Arg Asn Gln Glu Ala Cys Glu Leu Ser Asn Asn 
            180                 185             


<210>  1548
<211>  2475
<212>  DNA
<213>  Homosapiens

<400>  1548
ggtgcagctg cttccgggct tcgcggctcc cggcggctcc ccaaggccgc ggccccgacg     60

ctgggcccgg gagcggtccc cgcgcacagc gcccggacgc gtaggtcccg aagtaggccc    120

gcgctttgct tcgtaactgg ggatctctga ggacatctta gttctgacct tgtggaggcc    180

gcgtctctgc tgcgtgttcg cgggccagtc gggccacttt gtagaaatca tagccctcta    240

aatcaaggga cgaacgctgc tggctggagt ttgctggaca ctttcattcc acctcctaac    300

aaagagaatt cctattcctt gaggtccctt ggggcagcag ttaaagacta cacgatccag    360

gagcacctag gacctggggc caccttcctg cccgctttat tggatggagc actgcctccc    420

cagtttctgg gacaccttgg ggtgtggcct tggtgagtga aacttggggt gctgcctgct    480

gggaaggaaa tccggaaacg cagagaggac tctctggtgg tgacccaggc cttgtcagat    540

ctgagattct tggaatctca gattgtgggg gtgtggatgg tgaatgaatt tgggtatgcc    600

cccctttacc ccagaactga agaggaagca aactacttgc cacacttgag gctgcatgac    660

tattcagaga agggaggagc cacttctgaa ttcagagtag gactgcatca ccaggcaaat    720

acctgttctg agccagaaag actctggctt ctgaggagat cctgagagtc tgagtagtgc    780

caggaagcag cctcagaatt tgggggccca ttacacaccc cagccatgtt cctgcgacgg    840

cttggtggct ggctacctcg cccttggggc cgccggaaac caatgaggcc tgacccgcct    900

tacccagaac ccagacgggt ggacagctcc tcggagaatt caggaagtga ctgggatagt    960

gccccagaaa ccatggaaga tgtggggcat cccaagacta aggactcggg ggcattgagg   1020

gtttctgggg ctgcttccga accaagcaag gaggagcccc aagttgagca gctagggagc   1080

aaaagaatgg attccctcaa gtgggaccag cctatctcta gcactcaaga gtctgggaga   1140

ctggaggctg gaggggccag tcccaaactc agatgggatc atgtggattc aggtggcacc   1200

aggagaccag gggtgtcccc tgaaggggga ctgagcgtcc ctgggccagg agccccattg   1260

gagaaacctg gtaggcgtga gaagctgttg ggctggctgc ggggggaacc aggagctccc   1320

tcccggtact tggggggccc agaagagtgt ctgcagatct ccaccaacct gaccctgcat   1380

cttctggagc tgctggcctc tgccctgctg gccctgtgct cacgaccact gcgggcagcc   1440

ttggacacac tgggcctgcg tggaccgctg ggcctctggc tacatggcct actgtccttc   1500

ctggctgccc tgcatgggct ccatgctgtt ctgagcctac ttactgccca ccctttgcac   1560

ttcgcctgcc tctttggtct cctgcaggcc ttggtgctgg ctgtcagcct ccgggagccc   1620

aatggggatg aggcggccac tgactgggag agtgaggggt tggagaggga aggtgaggag   1680

cagaggggag acccgggaaa ggggctgtga ccgtggggtg ggggcaaagg gtgaagagag   1740

tgtgggcttt aggagaaaag tgtgaggcat gacccaaatt gtaagcatag ggacctcagg   1800

gatggggaag aaacccgagt acgagggtgc agggcccccc ttcatacaca ggagagaaca   1860

gaactattta gggtgtttgt gtttatggac agtgagggca ctgctcttgg attcaccagc   1920

tgttattttt gcttttactt ttctcccacc ttcagttttt tttttttttc cacctccact   1980

ttttaaaagc aaaaaaaaaa aaaagtatga tggtggtgaa taaagaccaa agggtcctct   2040

ctacctttga aaactctcct ggggtggagg agaccagggc aggatagaca gacctctgca   2100

gtaagagagt ggttgggaaa cccagggtgt tccttggatc tcaggatctg agccatcgag   2160

ggaagagtgg ggctgctagg caagtggatt agggggtctg gatagggccc cacaggtgac   2220

agggagcctg cagggcggat ctggtgatca tgggagccag agggagtggg gacagtgcag   2280

gcagtattgg caggagggcc agtgcagaag ggctggtagc tcaggcagtg tgggggaagc   2340

actgaagcct gtagtcccca cttgggggct aggggtttgc tcactcagca ataaataact   2400

gtgtcacatc aaatcctaaa tataccacta caaagtgaga gttactgcca ctctgttctt   2460

actgacaccg tccag                                                    2475


<210>  1549
<211>  294
<212>  PRT
<213>  Homosapiens

<400>  1549

Met Phe Leu Arg Arg Leu Gly Gly Trp Leu Pro Arg Pro Trp Gly Arg 
1               5                   10                  15      


Arg Lys Pro Met Arg Pro Asp Pro Pro Tyr Pro Glu Pro Arg Arg Val 
            20                  25                  30          


Asp Ser Ser Ser Glu Asn Ser Gly Ser Asp Trp Asp Ser Ala Pro Glu 
        35                  40                  45              


Thr Met Glu Asp Val Gly His Pro Lys Thr Lys Asp Ser Gly Ala Leu 
    50                  55                  60                  


Arg Val Ser Gly Ala Ala Ser Glu Pro Ser Lys Glu Glu Pro Gln Val 
65                  70                  75                  80  


Glu Gln Leu Gly Ser Lys Arg Met Asp Ser Leu Lys Trp Asp Gln Pro 
                85                  90                  95      


Ile Ser Ser Thr Gln Glu Ser Gly Arg Leu Glu Ala Gly Gly Ala Ser 
            100                 105                 110         


Pro Lys Leu Arg Trp Asp His Val Asp Ser Gly Gly Thr Arg Arg Pro 
        115                 120                 125             


Gly Val Ser Pro Glu Gly Gly Leu Ser Val Pro Gly Pro Gly Ala Pro 
    130                 135                 140                 


Leu Glu Lys Pro Gly Arg Arg Glu Lys Leu Leu Gly Trp Leu Arg Gly 
145                 150                 155                 160 


Glu Pro Gly Ala Pro Ser Arg Tyr Leu Gly Gly Pro Glu Glu Cys Leu 
                165                 170                 175     


Gln Ile Ser Thr Asn Leu Thr Leu His Leu Leu Glu Leu Leu Ala Ser 
            180                 185                 190         


Ala Leu Leu Ala Leu Cys Ser Arg Pro Leu Arg Ala Ala Leu Asp Thr 
        195                 200                 205             


Leu Gly Leu Arg Gly Pro Leu Gly Leu Trp Leu His Gly Leu Leu Ser 
    210                 215                 220                 


Phe Leu Ala Ala Leu His Gly Leu His Ala Val Leu Ser Leu Leu Thr 
225                 230                 235                 240 


Ala His Pro Leu His Phe Ala Cys Leu Phe Gly Leu Leu Gln Ala Leu 
                245                 250                 255     


Val Leu Ala Val Ser Leu Arg Glu Pro Asn Gly Asp Glu Ala Ala Thr 
            260                 265                 270         


Asp Trp Glu Ser Glu Gly Leu Glu Arg Glu Gly Glu Glu Gln Arg Gly 
        275                 280                 285             


Asp Pro Gly Lys Gly Leu 
    290                 


<210>  1550
<211>  1920
<212>  DNA
<213>  Homosapiens

<400>  1550
gtgacgttat ttcattacac ggcttctcgg cattccacag gtttccctcc gcctcctgag     60

ggcctttcct aacccacaga gtggattcct ggctccagaa aatgggcttg gagcgggggc    120

cacgttgagg aaggcgaagg gcattgtggg ggcgttatgt aaaagtagga ccccaaccga    180

cagatcctag tgctcgcgcc acctgggcgc gcggagcttt gctcgtttac tattgaaaaa    240

gttccagcgc gggaaactga acccggagct ttgcgcacgc ccgagccctc aagtaatgtg    300

ggttgtggtt tttgttgttg ttgtcgccac gcatgcgtct tcgtgccgtg tggctatttg    360

attgtgtcaa ctcttctgat tagaatggcg ccattttgcg gtacggaagc tacacagcaa    420

cacgtatagg agactctccc cgagatcttc tagggagtga cccatctatt tttgtttggg    480

aagaggaaac tccgaaatgg gatcgcggaa gacttaaagg gccaggctga tttttttttc    540

ctactggtct ctgaggctgt ggttgctaca gggtcaccac gagcttggct tacttgtctc    600

atccttccct tgcctggtat cattttctca gttctcccaa aagccatgtc ccggcccttg    660

ctcatcacct tcaccccagc cactgacccc agcgacctct ggaaggatgg gcagcagcag    720

ccacagcccg agaagccaga gtccaccctg gatggggctg cagcccgagc tttctatgag    780

gccctgattg gggatgagag cagcgctcct gactcccaga gatctcagac tgaacctgcc    840

agagaaagaa agagaaagaa aagaagaata atgaaggcac cagcagcaga agcagtggca    900

gaaggagcat caggaagaca tggacaaggg agatcccttg aggctgagga taagatgact    960

caccggatac tgagggcagc ccaggagggg gacctgccag aacttaggag actgctggaa   1020

ccgcatgagg caggaggagc tggggggaat atcaacgccc gggatgcctt ctggtggacc   1080

ccactgatgt gtgctgctcg agcgggccag ggggcagctg tgagctatct cctgggccgt   1140

ggggctgcct gggtgggggt ctgtgagctg agtggcaggg atgcggctca gctcgctgaa   1200

gaagctggct tccctgaggt agcccgcatg gtcagggaga gccatggaga gacaaggagc   1260

ccggaaaacc ggtctcctac tccctccctc cagtactgcg agaactgtga cacccacttc   1320

caagattcca accaccgcac atccactgct cacctgctgt cactgtcgca gggtcctcag   1380

cctcccaacc ttccacttgg ggtgcccatc tccagcccgg gcttcaaact gctgctgagg   1440

gggggctggg agccaggaat ggggctggga ccccggggtg agggccgtgc caatcccatc   1500

cccactgtcc tcaagaggga ccaggaagga ctaggctaca gatcagcacc ccagccccga   1560

gtgacacatt tcccagcttg ggatacccga gctgtggctg ggagggagag accccctcgg   1620

gtggccacac tgagctggag ggaggagaga aggagggagg agaaagacag ggcttgggag   1680

cgggatctaa ggacttacat gaacctcgag ttctgacttt ggtaaagtct gaccctagtc   1740

tgctgctgaa gtctgaactt gggcctctga cctgggccct ttgacttccc cttcctggga   1800

tctgctcaga tgcagatcct gaagtttttg gtcaataggc tctgtcttcg tgagagacgg   1860

gctgagagtc agaaataaat caaccatttg tggtttaaaa aaaaaaaaaa aaaaaaaaaa   1920


<210>  1551
<211>  356
<212>  PRT
<213>  Homosapiens

<400>  1551

Met Ser Arg Pro Leu Leu Ile Thr Phe Thr Pro Ala Thr Asp Pro Ser 
1               5                   10                  15      


Asp Leu Trp Lys Asp Gly Gln Gln Gln Pro Gln Pro Glu Lys Pro Glu 
            20                  25                  30          


Ser Thr Leu Asp Gly Ala Ala Ala Arg Ala Phe Tyr Glu Ala Leu Ile 
        35                  40                  45              


Gly Asp Glu Ser Ser Ala Pro Asp Ser Gln Arg Ser Gln Thr Glu Pro 
    50                  55                  60                  


Ala Arg Glu Arg Lys Arg Lys Lys Arg Arg Ile Met Lys Ala Pro Ala 
65                  70                  75                  80  


Ala Glu Ala Val Ala Glu Gly Ala Ser Gly Arg His Gly Gln Gly Arg 
                85                  90                  95      


Ser Leu Glu Ala Glu Asp Lys Met Thr His Arg Ile Leu Arg Ala Ala 
            100                 105                 110         


Gln Glu Gly Asp Leu Pro Glu Leu Arg Arg Leu Leu Glu Pro His Glu 
        115                 120                 125             


Ala Gly Gly Ala Gly Gly Asn Ile Asn Ala Arg Asp Ala Phe Trp Trp 
    130                 135                 140                 


Thr Pro Leu Met Cys Ala Ala Arg Ala Gly Gln Gly Ala Ala Val Ser 
145                 150                 155                 160 


Tyr Leu Leu Gly Arg Gly Ala Ala Trp Val Gly Val Cys Glu Leu Ser 
                165                 170                 175     


Gly Arg Asp Ala Ala Gln Leu Ala Glu Glu Ala Gly Phe Pro Glu Val 
            180                 185                 190         


Ala Arg Met Val Arg Glu Ser His Gly Glu Thr Arg Ser Pro Glu Asn 
        195                 200                 205             


Arg Ser Pro Thr Pro Ser Leu Gln Tyr Cys Glu Asn Cys Asp Thr His 
    210                 215                 220                 


Phe Gln Asp Ser Asn His Arg Thr Ser Thr Ala His Leu Leu Ser Leu 
225                 230                 235                 240 


Ser Gln Gly Pro Gln Pro Pro Asn Leu Pro Leu Gly Val Pro Ile Ser 
                245                 250                 255     


Ser Pro Gly Phe Lys Leu Leu Leu Arg Gly Gly Trp Glu Pro Gly Met 
            260                 265                 270         


Gly Leu Gly Pro Arg Gly Glu Gly Arg Ala Asn Pro Ile Pro Thr Val 
        275                 280                 285             


Leu Lys Arg Asp Gln Glu Gly Leu Gly Tyr Arg Ser Ala Pro Gln Pro 
    290                 295                 300                 


Arg Val Thr His Phe Pro Ala Trp Asp Thr Arg Ala Val Ala Gly Arg 
305                 310                 315                 320 


Glu Arg Pro Pro Arg Val Ala Thr Leu Ser Trp Arg Glu Glu Arg Arg 
                325                 330                 335     


Arg Glu Glu Lys Asp Arg Ala Trp Glu Arg Asp Leu Arg Thr Tyr Met 
            340                 345                 350         


Asn Leu Glu Phe 
        355     


<210>  1552
<211>  1128
<212>  DNA
<213>  Homosapiens

<400>  1552
gcttctcgtt gtgccccgcc cgcaagcgcc ctcctccggg ccttcgtgac agccaggtcg     60

tgcgcgggtc atcctgggat tggtagttcg ctttctctca tttagccagt ttctttctct    120

accggggact ccgtgtcccg gcatccaccg cggcacctga cccttggcgc ttgcgtgttg    180

ccctcttccc caccctccct aatttccact ccccccaccc cacttcgcct gccgcggtcg    240

ggtccgcggc ctgcgctgta gcggtcgccg ccgttccctg gaagtagcaa cttccctacc    300

ccaccccagt cctggtcccc gtccagccgc tgacgtgaag atgagcagct cagaggaggt    360

gtcctggatt tcctggttct gtgggctccg tggcaatgaa ttcttctgtg aagtggatga    420

agactacatc caggacaaat ttaatcttac tggactcaat gagcaggtcc ctcactaccg    480

acaagctcta gacatgatct tggacctgga gcctgatgaa gaactggaag acaaccccaa    540

ccagagtgac ctgattgagc aggcagccga gatgctttat ggattgatcc acgcccgcta    600

catccttacc aaccgtggca tcgcccagat gttggaaaag taccagcaag gagactttgg    660

ttactgtcct cgtgtgtact gtgagaacca gccaatgctt cccattggcc tttcagacat    720

cccaggtgaa gccatggtga agctctactg ccccaagtgc atggatgtgt acacacccaa    780

gtcatcaaga caccatcaca cggatggcgc ctacttcggc actggtttcc ctcacatgct    840

cttcatggtg catcccgagt accggcccaa gagacctgcc aaccagtttg tgcccaggct    900

ctacggtttc aagatccatc cgatggccta ccagctgcag ctccaagccg ccagcaactt    960

caagagccca gtcaagacga ttcgctgatt ccctccccca cctgtcctgc agtctttgac   1020

ttttcctttc ttttttgcca ccctttcagg aaccctgtat ggtttttagt ttaaattaaa   1080

ggagtcgtta ttgtggtggg aatatgaaat aaagtagaag aaaaggcc                1128


<210>  1553
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  1553

Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
1               5                   10                  15      


Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
            20                  25                  30          


Lys Phe Asn Leu Thr Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
        35                  40                  45              


Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
    50                  55                  60                  


Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
65                  70                  75                  80  


Gly Leu Ile His Ala Arg Tyr Ile Leu Thr Asn Arg Gly Ile Ala Gln 
                85                  90                  95      


Met Leu Glu Lys Tyr Gln Gln Gly Asp Phe Gly Tyr Cys Pro Arg Val 
            100                 105                 110         


Tyr Cys Glu Asn Gln Pro Met Leu Pro Ile Gly Leu Ser Asp Ile Pro 
        115                 120                 125             


Gly Glu Ala Met Val Lys Leu Tyr Cys Pro Lys Cys Met Asp Val Tyr 
    130                 135                 140                 


Thr Pro Lys Ser Ser Arg His His His Thr Asp Gly Ala Tyr Phe Gly 
145                 150                 155                 160 


Thr Gly Phe Pro His Met Leu Phe Met Val His Pro Glu Tyr Arg Pro 
                165                 170                 175     


Lys Arg Pro Ala Asn Gln Phe Val Pro Arg Leu Tyr Gly Phe Lys Ile 
            180                 185                 190         


His Pro Met Ala Tyr Gln Leu Gln Leu Gln Ala Ala Ser Asn Phe Lys 
        195                 200                 205             


Ser Pro Val Lys Thr Ile Arg 
    210                 215 


<210>  1554
<211>  774
<212>  DNA
<213>  Homosapiens

<400>  1554
atgaaggtcc atatgcttgt aggtgtgctg gtcatggtgg gcttcacagt aggaaaggtt     60

cctgttcccg acatccggac gtgccacttc tgcctcgtag aagacccttc tgtaggatgc    120

atttcaggct cagagaagtg taccatcagc agctcatccc tgtgcatggt gatcaccatc    180

tattatgatg tcaaggttcg cttcatcgtt cgaggctgtg gacagtacat ttcctaccgc    240

tgccaagaaa aacgcaacac ctactttgca gagtactggt atcaggccca gtgctgtcag    300

tacgattatt gcaactcctg gtcaagcccc caactccaga gctctctgcc ggagccccat    360

gacaggcccc tggccctgcc tctgtctgac tcccagattc agtggttcta ccaggccctg    420

aacctctccc tgcccctccc caatttccat gctgggacgg agcctgatgg cctggacccc    480

atggtcacac tgtccctgaa cctgggcttg tcttttgctg agctgcgccg catgtacttg    540

ttcctcaata gttcaggact tttggttctt ccccaggctg gactcttgac acctcaccct    600

tcctgaattc cacagtgcaa atatctttct gtaacaccct cagcatcctg cactgccctc    660

tctgaaaaca cccacattct ttggtcactg tgatttctta ggcctccgtc tgttgtacca    720

ctagcatcta tatgactttt gtgtaatttt ctctcttgaa ctctggtgct gttt          774


<210>  1555
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  1555

Met Lys Val His Met Leu Val Gly Val Leu Val Met Val Gly Phe Thr 
1               5                   10                  15      


Val Gly Lys Val Pro Val Pro Asp Ile Arg Thr Cys His Phe Cys Leu 
            20                  25                  30          


Val Glu Asp Pro Ser Val Gly Cys Ile Ser Gly Ser Glu Lys Cys Thr 
        35                  40                  45              


Ile Ser Ser Ser Ser Leu Cys Met Val Ile Thr Ile Tyr Tyr Asp Val 
    50                  55                  60                  


Lys Val Arg Phe Ile Val Arg Gly Cys Gly Gln Tyr Ile Ser Tyr Arg 
65                  70                  75                  80  


Cys Gln Glu Lys Arg Asn Thr Tyr Phe Ala Glu Tyr Trp Tyr Gln Ala 
                85                  90                  95      


Gln Cys Cys Gln Tyr Asp Tyr Cys Asn Ser Trp Ser Ser Pro Gln Leu 
            100                 105                 110         


Gln Ser Ser Leu Pro Glu Pro His Asp Arg Pro Leu Ala Leu Pro Leu 
        115                 120                 125             


Ser Asp Ser Gln Ile Gln Trp Phe Tyr Gln Ala Leu Asn Leu Ser Leu 
    130                 135                 140                 


Pro Leu Pro Asn Phe His Ala Gly Thr Glu Pro Asp Gly Leu Asp Pro 
145                 150                 155                 160 


Met Val Thr Leu Ser Leu Asn Leu Gly Leu Ser Phe Ala Glu Leu Arg 
                165                 170                 175     


Arg Met Tyr Leu Phe Leu Asn Ser Ser Gly Leu Leu Val Leu Pro Gln 
            180                 185                 190         


Ala Gly Leu Leu Thr Pro His Pro Ser 
        195                 200     


<210>  1556
<211>  842
<212>  DNA
<213>  Homosapiens

<400>  1556
atgcagacct tcccagttgc tggggcgctg gaccctgcta tactggacac aaggtttctt     60

ccccagggaa cagagcttga gcggggggcc acccccccgt cctaccggag ttctgaggtg    120

cggtcaggcg cggagagcgg acgcccagcg ccagattctg tgggctccgg agttcaggcc    180

cactgagccg cagctgagca caggcggggc aggaaaaagg atgaggtaag tttgttcctg    240

tcaattggga accccctcaa ccacttccat tccccaaata cctgcgctgc taccgatgcc    300

tcttggagac caaggagtta gggtgccttc tgggatctga catctgcctc accccagctg    360

gcagcagctg catcactctc cacaaaaaga acagcagcgg ttctgacgtc atggtgagtg    420

actgccgaag taaggagcag atgagtgatt gttcaaatac ccgaacttct ccggtgtctg    480

gcttctggat attctctcaa tactgcttcc tggatttctg caatgaccct caaaacagag    540

ggctctatac tccttagtgt gactgcagca aactttggtg taaaattcca ccagtttcca    600

gccaccttcc tgacttctat ctgggcttgg ccaggacttc tagtccctca taccagccct    660

ccttgcctcc ctccagccac tggaccccag ccttggctct tcctcttggt tgacgccctt    720

cagcacactt actgctactc tgtaccccca gccctactgc ccaccaggtt tcctctcttg    780

tcccctagtc cctggatgtt tctcccaaat aaatttgtgt gtaaactgtt aaaaaaaaaa    840

aa                                                                   842


<210>  1557
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  1557

Met Gln Thr Phe Pro Val Ala Gly Ala Leu Asp Pro Ala Ile Leu Asp 
1               5                   10                  15      


Thr Arg Phe Leu Pro Gln Gly Thr Glu Leu Glu Arg Gly Ala Thr Pro 
            20                  25                  30          


Pro Ser Tyr Arg Ser Ser Glu Val Arg Ser Gly Ala Glu Ser Gly Arg 
        35                  40                  45              


Pro Ala Pro Asp Ser Val Gly Ser Gly Val Gln Ala His 
    50                  55                  60      


<210>  1558
<211>  823
<212>  DNA
<213>  Homosapiens

<400>  1558
atggcaggcc ctgcagggag ccagagtctg ggtcccctgt gcttccacag cagcccccaa     60

gccctctaca cggtcctctt aatagtgctg gtcatgatga gcttggtgtt tggtaagtgg    120

ctccaagggt tcagaagggt ctcctggcct ggatggagaa acccacagac accaagtgtc    180

tgggtacacc tgtccaggat gctcaggtaa gtttgttcct gtcaattggg aaccccctca    240

accacttcca ttccccaaat acctgcgctg ctaccgatgc ctcttggaga ccaaggagtt    300

agggtgcctt ctgggatctg acatctgcct caccccagct ggcagcagct gcatcactct    360

ccacaaaaag aacagcagcg gttctgacgt catggtgagt gactgccgaa gtaaggagca    420

gatgagtgat tgttcaaata cccgaacttc tccggtgtct ggcttctgga tattctctca    480

atactgcttc ctggatttct gcaatgaccc tcaaaacaga gggctctata ctccttagtg    540

tgactgcagc aaactttggt gtaaaattcc accagtttcc agccaccttc ctgacttcta    600

tctgggcttg gccaggactt ctagtccctc ataccagccc tccttgcctc cctccagcca    660

ctggacccca gccttggctc ttcctcttgg ttgacgccct tcagcacact tactgctact    720

ctgtaccccc agccctactg cccaccaggt ttcctctctt gtcccctagt ccctggatgt    780

ttctcccaaa taaatttgtg tgtaaactgt taaaaaaaaa aaa                      823


<210>  1559
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  1559

Met Ala Gly Pro Ala Gly Ser Gln Ser Leu Gly Pro Leu Cys Phe His 
1               5                   10                  15      


Ser Ser Pro Gln Ala Leu Tyr Thr Val Leu Leu Ile Val Leu Val Met 
            20                  25                  30          


Met Ser Leu Val Phe Gly Lys Trp Leu Gln Gly Phe Arg Arg Val Ser 
        35                  40                  45              


Trp Pro Gly Trp Arg Asn Pro Gln Thr Pro Ser Val Trp Val His Leu 
    50                  55                  60                  


Ser Arg Met Leu Arg 
65                  


<210>  1560
<211>  729
<212>  DNA
<213>  Homosapiens

<400>  1560
atggcaggcc ctgcagggag ccagagtctg ggtcccctgt gcttccacag cagcccccaa     60

gccctctaca cggtcctctt aatagtgctg gtcatgatga gcttggtgtt tggtaagttt    120

gttcctgtca attgggaacc ccctcaacca cttccattcc ccaaatacct gcgctgctac    180

cgatgcctct tggagaccaa ggagttaggg tgccttctgg gatctgacat ctgcctcacc    240

ccagctggca gcagctgcat cactctccac aaaaagaaca gcagcggttc tgacgtcatg    300

gtgagtgact gccgaagtaa ggagcagatg agtgattgtt caaatacccg aacttctccg    360

gtgtctggct tctggatatt ctctcaatac tgcttcctgg atttctgcaa tgaccctcaa    420

aacagagggc tctatactcc ttagtgtgac tgcagcaaac tttggtgtaa aattccacca    480

gtttccagcc accttcctga cttctatctg ggcttggcca ggacttctag tccctcatac    540

cagccctcct tgcctccctc cagccactgg accccagcct tggctcttcc tcttggttga    600

cgcccttcag cacacttact gctactctgt acccccagcc ctactgccca ccaggtttcc    660

tctcttgtcc cctagtccct ggatgtttct cccaaataaa tttgtgtgta aactgttaaa    720

aaaaaaaaa                                                            729


<210>  1561
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  1561

Met Ala Gly Pro Ala Gly Ser Gln Ser Leu Gly Pro Leu Cys Phe His 
1               5                   10                  15      


Ser Ser Pro Gln Ala Leu Tyr Thr Val Leu Leu Ile Val Leu Val Met 
            20                  25                  30          


Met Ser Leu Val Phe Gly Lys Phe Val Pro Val Asn Trp Glu Pro Pro 
        35                  40                  45              


Gln Pro Leu Pro Phe Pro Lys Tyr Leu Arg Cys Tyr Arg Cys Leu Leu 
    50                  55                  60                  


Glu Thr Lys Glu Leu Gly Cys Leu Leu Gly Ser Asp Ile Cys Leu Thr 
65                  70                  75                  80  


Pro Ala Gly Ser Ser Cys Ile Thr Leu His Lys Lys Asn Ser Ser Gly 
                85                  90                  95      


Ser Asp Val Met Val Ser Asp Cys Arg Ser Lys Glu Gln Met Ser Asp 
            100                 105                 110         


Cys Ser Asn Thr Arg Thr Ser Pro Val Ser Gly Phe Trp Ile Phe Ser 
        115                 120                 125             


Gln Tyr Cys Phe Leu Asp Phe Cys Asn Asp Pro Gln Asn Arg Gly Leu 
    130                 135                 140                 


Tyr Thr Pro 
145         


<210>  1562
<211>  1960
<212>  DNA
<213>  Homosapiens

<400>  1562
gctggaagag cagcggcccg agccggggcc atggcgaagc tgctgagctg cgtcctaggc     60

ccccggctct acaaaatcta ccgggagagg gactctgaaa gggccccggc cagcgtccct    120

gagacgccaa cggcagtcac tgccccccat tccagctcct gggatacgta ctatcagccc    180

cgtgccctgg agaaacatgc tgacagcatc ctggcactgg cttcagtatt ctggtccatc    240

tcttattact cctctccctt cgccttcttc tacttgtaca ggaaaggtta cttgagtttg    300

tccaaagtgg tgccgttttc tcactatgct gggacattgc tgctacttct ggcaggtgtg    360

gcctgcctcc gaggcattgg ccgctggacc aacccccagt accggcagtt catcaccatc    420

ttggaagcaa cacatcggaa ccagtcttca gaaaacaaga ggcagcttgc caactacaac    480

tttgacttcc ggagctggcc agtcgacttc cactgggaag aacccagcag ccggaaggag    540

tctcgagggg gcccttcccg ccggggtgtg gccctgcttc gcccagagcc cctgcaccgg    600

gggacagcag acaccctcct caaccgggtt aagaagctgc cttgtcagat caccagctac    660

ctggtggcgc acaccctagg gcgccggatg ctgtatccag gctctgtgta cctgctgcag    720

aaggccctca tgcctgtgct gctgcagggc caggcccgac tggtggaaga gtgtaatggg    780

cgccgggcaa agctgctggc ctgtgatggc aatgagattg acaccatgtt tgtggaccgg    840

cgggggacag ctgagcccca gggacagaag ctggtgatct gctgtgaggg gaatgctggg    900

ttttatgagg tgggctgcgt ctccacgccc ctggaagctg gatattcagt cctgggctgg    960

aatcatccag gctttgctgg aagcacgggg gtgccattcc cgcagaatga ggctaatgcc   1020

atggatgtgg tggtccagtt tgccatccac cgcctgggct tccagcccca ggacatcatc   1080

atctacgcct ggtccatcgg cggcttcact gccacgtggg cagccatgtc ctacccagat   1140

gttagtgcca tgatcctgga tgcctccttt gatgacctgg tgcccttggc cttgaaggtc   1200

atgccagaca gctggagggg cctggtgacc aggaccgtga ggcagcatct caatctaaac   1260

aacgcggagc agctgtgcag ataccagggt cctgtactgc tgatccggag aaccaaggat   1320

gagatcatca ccaccacggt tcctgaggac atcatgtcca accgaggcaa tgacctcctg   1380

ctgaagctcc tgcagcatcg gtatccccgg gtgatggcag aggagggtct tcgagtggtg   1440

aggcagtggt tggaggcctc ctcacagctg gaggaagcct caatttatag ccgatgggag   1500

gtggaagagg actggtgtct gtctgtcctc cgctcctacc aggcagaaca cgggcccgac   1560

ttcccctgga gcgtggggga ggacatgagt gcagatggac ggcggcagct ggctttgttt   1620

ctggctcgga agcatctgca caactttgag gccactcact gcaccccact cccagcccag   1680

aacttccaga tgccctggca cctctaggga ccaactggga ctcattatgg aagaatgggg   1740

tgagaggaga catgaggaaa gaccctctta tttgtgattc tctgtgttca tgttgctgtt   1800

tatagtttgt ggaaagtggg ggaccatccc ccttctcacc actgttcctc ttgcacgttt   1860

cccctcattc atgtggctgt acttaacctt ctccaacata catcctgcat tacatgaatg   1920

gattattcct aataattaat aaaaaggtat tttttctact                         1960


<210>  1563
<211>  558
<212>  PRT
<213>  Homosapiens

<400>  1563

Met Ala Lys Leu Leu Ser Cys Val Leu Gly Pro Arg Leu Tyr Lys Ile 
1               5                   10                  15      


Tyr Arg Glu Arg Asp Ser Glu Arg Ala Pro Ala Ser Val Pro Glu Thr 
            20                  25                  30          


Pro Thr Ala Val Thr Ala Pro His Ser Ser Ser Trp Asp Thr Tyr Tyr 
        35                  40                  45              


Gln Pro Arg Ala Leu Glu Lys His Ala Asp Ser Ile Leu Ala Leu Ala 
    50                  55                  60                  


Ser Val Phe Trp Ser Ile Ser Tyr Tyr Ser Ser Pro Phe Ala Phe Phe 
65                  70                  75                  80  


Tyr Leu Tyr Arg Lys Gly Tyr Leu Ser Leu Ser Lys Val Val Pro Phe 
                85                  90                  95      


Ser His Tyr Ala Gly Thr Leu Leu Leu Leu Leu Ala Gly Val Ala Cys 
            100                 105                 110         


Leu Arg Gly Ile Gly Arg Trp Thr Asn Pro Gln Tyr Arg Gln Phe Ile 
        115                 120                 125             


Thr Ile Leu Glu Ala Thr His Arg Asn Gln Ser Ser Glu Asn Lys Arg 
    130                 135                 140                 


Gln Leu Ala Asn Tyr Asn Phe Asp Phe Arg Ser Trp Pro Val Asp Phe 
145                 150                 155                 160 


His Trp Glu Glu Pro Ser Ser Arg Lys Glu Ser Arg Gly Gly Pro Ser 
                165                 170                 175     


Arg Arg Gly Val Ala Leu Leu Arg Pro Glu Pro Leu His Arg Gly Thr 
            180                 185                 190         


Ala Asp Thr Leu Leu Asn Arg Val Lys Lys Leu Pro Cys Gln Ile Thr 
        195                 200                 205             


Ser Tyr Leu Val Ala His Thr Leu Gly Arg Arg Met Leu Tyr Pro Gly 
    210                 215                 220                 


Ser Val Tyr Leu Leu Gln Lys Ala Leu Met Pro Val Leu Leu Gln Gly 
225                 230                 235                 240 


Gln Ala Arg Leu Val Glu Glu Cys Asn Gly Arg Arg Ala Lys Leu Leu 
                245                 250                 255     


Ala Cys Asp Gly Asn Glu Ile Asp Thr Met Phe Val Asp Arg Arg Gly 
            260                 265                 270         


Thr Ala Glu Pro Gln Gly Gln Lys Leu Val Ile Cys Cys Glu Gly Asn 
        275                 280                 285             


Ala Gly Phe Tyr Glu Val Gly Cys Val Ser Thr Pro Leu Glu Ala Gly 
    290                 295                 300                 


Tyr Ser Val Leu Gly Trp Asn His Pro Gly Phe Ala Gly Ser Thr Gly 
305                 310                 315                 320 


Val Pro Phe Pro Gln Asn Glu Ala Asn Ala Met Asp Val Val Val Gln 
                325                 330                 335     


Phe Ala Ile His Arg Leu Gly Phe Gln Pro Gln Asp Ile Ile Ile Tyr 
            340                 345                 350         


Ala Trp Ser Ile Gly Gly Phe Thr Ala Thr Trp Ala Ala Met Ser Tyr 
        355                 360                 365             


Pro Asp Val Ser Ala Met Ile Leu Asp Ala Ser Phe Asp Asp Leu Val 
    370                 375                 380                 


Pro Leu Ala Leu Lys Val Met Pro Asp Ser Trp Arg Gly Leu Val Thr 
385                 390                 395                 400 


Arg Thr Val Arg Gln His Leu Asn Leu Asn Asn Ala Glu Gln Leu Cys 
                405                 410                 415     


Arg Tyr Gln Gly Pro Val Leu Leu Ile Arg Arg Thr Lys Asp Glu Ile 
            420                 425                 430         


Ile Thr Thr Thr Val Pro Glu Asp Ile Met Ser Asn Arg Gly Asn Asp 
        435                 440                 445             


Leu Leu Leu Lys Leu Leu Gln His Arg Tyr Pro Arg Val Met Ala Glu 
    450                 455                 460                 


Glu Gly Leu Arg Val Val Arg Gln Trp Leu Glu Ala Ser Ser Gln Leu 
465                 470                 475                 480 


Glu Glu Ala Ser Ile Tyr Ser Arg Trp Glu Val Glu Glu Asp Trp Cys 
                485                 490                 495     


Leu Ser Val Leu Arg Ser Tyr Gln Ala Glu His Gly Pro Asp Phe Pro 
            500                 505                 510         


Trp Ser Val Gly Glu Asp Met Ser Ala Asp Gly Arg Arg Gln Leu Ala 
        515                 520                 525             


Leu Phe Leu Ala Arg Lys His Leu His Asn Phe Glu Ala Thr His Cys 
    530                 535                 540                 


Thr Pro Leu Pro Ala Gln Asn Phe Gln Met Pro Trp His Leu 
545                 550                 555             


<210>  1564
<211>  402
<212>  DNA
<213>  Homosapiens

<400>  1564
atgaaacccc agtttgttgg gatcttgctc agctccctgc taggggctgc cttgggaaac     60

cgaatgcggt gctacaactg tggtggaagc cccagcagtt cttgcaaaga ggccgtgacc    120

acctgtggcg agggcagacc ccagccaggc ctggaacaga tcaagctacc tggaaacccc    180

ccagtgacct tgattcacca acatccagcc tgcgtcgcag cccatcattg caatcaagtg    240

gagacagagt cggtgggaga cgtgacttat ccagcccaca gggactgcta cctgggagac    300

ctgtgcaaca gcgccgtggc aagccatgtg gcccctgcag gcattttggc tgcagcagct    360

accgccctga cctgtctctt gccaggactg tggagcggat ag                       402


<210>  1565
<211>  133
<212>  PRT
<213>  Homosapiens

<400>  1565

Met Lys Pro Gln Phe Val Gly Ile Leu Leu Ser Ser Leu Leu Gly Ala 
1               5                   10                  15      


Ala Leu Gly Asn Arg Met Arg Cys Tyr Asn Cys Gly Gly Ser Pro Ser 
            20                  25                  30          


Ser Ser Cys Lys Glu Ala Val Thr Thr Cys Gly Glu Gly Arg Pro Gln 
        35                  40                  45              


Pro Gly Leu Glu Gln Ile Lys Leu Pro Gly Asn Pro Pro Val Thr Leu 
    50                  55                  60                  


Ile His Gln His Pro Ala Cys Val Ala Ala His His Cys Asn Gln Val 
65                  70                  75                  80  


Glu Thr Glu Ser Val Gly Asp Val Thr Tyr Pro Ala His Arg Asp Cys 
                85                  90                  95      


Tyr Leu Gly Asp Leu Cys Asn Ser Ala Val Ala Ser His Val Ala Pro 
            100                 105                 110         


Ala Gly Ile Leu Ala Ala Ala Ala Thr Ala Leu Thr Cys Leu Leu Pro 
        115                 120                 125             


Gly Leu Trp Ser Gly 
    130             


<210>  1566
<211>  383
<212>  DNA
<213>  Homosapiens

<400>  1566
atgggcacct ccagcatctt cctctgcgtg ctgttcctct gtggggcact gggtctcacc     60

atgtcccctg cccggggaag gctccgctgc tacatctgtg gcttcaccaa accctgccac    120

cctgttccca ccgagtgtcg ggacgatgaa gcttgtggca tcagtattgg cacttcagga    180

aaaagctgcc tctcaagggc ccagtgccct ctgccaggct atgccaccta ctggctgcac    240

tcctacactc tgtggcacca ctgctgcgag caggacctgt gcaacatagc cgcttcccca    300

cagcagctca ccagcctcct cgcctccctg cccctctttg tggccagctt cgctgggaga    360

ggacacctcc tccactagct tcc                                            383


<210>  1567
<211>  125
<212>  PRT
<213>  Homosapiens

<400>  1567

Met Gly Thr Ser Ser Ile Phe Leu Cys Val Leu Phe Leu Cys Gly Ala 
1               5                   10                  15      


Leu Gly Leu Thr Met Ser Pro Ala Arg Gly Arg Leu Arg Cys Tyr Ile 
            20                  25                  30          


Cys Gly Phe Thr Lys Pro Cys His Pro Val Pro Thr Glu Cys Arg Asp 
        35                  40                  45              


Asp Glu Ala Cys Gly Ile Ser Ile Gly Thr Ser Gly Lys Ser Cys Leu 
    50                  55                  60                  


Ser Arg Ala Gln Cys Pro Leu Pro Gly Tyr Ala Thr Tyr Trp Leu His 
65                  70                  75                  80  


Ser Tyr Thr Leu Trp His His Cys Cys Glu Gln Asp Leu Cys Asn Ile 
                85                  90                  95      


Ala Ala Ser Pro Gln Gln Leu Thr Ser Leu Leu Ala Ser Leu Pro Leu 
            100                 105                 110         


Phe Val Ala Ser Phe Ala Gly Arg Gly His Leu Leu His 
        115                 120                 125 


<210>  1568
<211>  880
<212>  DNA
<213>  Homosapiens

<400>  1568
tgaaaatcta ctctatcagc tgctgtggtt gccaccattc tcaggaccct cgccatgaaa     60

gcccttatgc tgctcaccct gtctgttctg ctctgctggg tctcagctga cattcgctgt    120

cactcctgct acaaggtccc tgtgctgggc tgtgtggacc ggcagtcctg ccgcctggag    180

ccaggacagc aatgcctgac aacacatgca taccttggta agatgtgggt tttctccaat    240

ctgcgctgtg gcacaccaga agagccctgt caggaggcct tcaaccaaac caaccgtaag    300

ctgggtctga catataacac cacctgctgc aacaaggaca actgcaacag cgcaggaccc    360

cggcccactc cagccctggg ccttgtcttc cttacctcct tggctggcct tggcctctgg    420

ctgctgcact gagactcatt ccattggctg cccctcctcc cacctgcctt ggcctgagcc    480

tctctccctg tgtctctgta tcccctggct ttacagaatc gtctctccct agctcccatt    540

tctttaatta aacactgttc cgagtggtct cctcatccgt ccttcccacc tcacaccctt    600

cactctcctt tttctgggtc ccttcccact tccttccagg acctccattg gctcctagaa    660

gggctcccca ctttgcttcc tatactctgc tgtcccctac ttgaggaggg attgggatct    720

gggcctgaaa tggggcttct gtgttgtccc cagtgaaggc tcccacaagg acctgatgac    780

ctcactgtac agagctgact ccccaaatcc aggctcccat atgtacccca tcccccatac    840

tcacctcttt ccattttgag taataaatgt ctgagtctga                          880


<210>  1569
<211>  125
<212>  PRT
<213>  Homosapiens

<400>  1569

Met Lys Ala Leu Met Leu Leu Thr Leu Ser Val Leu Leu Cys Trp Val 
1               5                   10                  15      


Ser Ala Asp Ile Arg Cys His Ser Cys Tyr Lys Val Pro Val Leu Gly 
            20                  25                  30          


Cys Val Asp Arg Gln Ser Cys Arg Leu Glu Pro Gly Gln Gln Cys Leu 
        35                  40                  45              


Thr Thr His Ala Tyr Leu Gly Lys Met Trp Val Phe Ser Asn Leu Arg 
    50                  55                  60                  


Cys Gly Thr Pro Glu Glu Pro Cys Gln Glu Ala Phe Asn Gln Thr Asn 
65                  70                  75                  80  


Arg Lys Leu Gly Leu Thr Tyr Asn Thr Thr Cys Cys Asn Lys Asp Asn 
                85                  90                  95      


Cys Asn Ser Ala Gly Pro Arg Pro Thr Pro Ala Leu Gly Leu Val Phe 
            100                 105                 110         


Leu Thr Ser Leu Ala Gly Leu Gly Leu Trp Leu Leu His 
        115                 120                 125 


<210>  1570
<211>  745
<212>  DNA
<213>  Homosapiens

<400>  1570
atggctgtgt ttctgcagct gctaccgctg ctgctctcga gggcccaagg gaaccctggg     60

gcttctctgg acggccgccc tggggaccgg gtgaatctct cctgcggagg agtctctcat    120

cccatccgct gggtctgggc acccagcttc ccggcctgca agggcctgtc caaaggacgc    180

cgaccgatcc tgtgggcctc ttcgagcggg acccccaccg tgcctcccct ccagcctttc    240

gtcggccgcc tacgctccct ggactctggt atccggcggc tggagctcct cttgagcgcg    300

ggagactcgg gcactttttt ctgcaagggc cgccacgagg acgagagccg tacagtgctt    360

cacgtgctgg gggacaggac ctattgcaag gcccccgggc ctacccatgg gtccgtgtat    420

ccccagctcc tgatcccgct gctgggcgct gggttggtgc tcggactggg agctttgggc    480

ctggtctggt ggctgcacag gcgcctgccc ccgcaaccga ttcgaccact ccctagattt    540

gctctgtccc ccccacatag ctccacttgt gaaaaccgag ccccagaggc cagtaaagga    600

ggaagagccc aagattccag gggacctgga ccaggaaccg agcctgctct atgcggatct    660

ggaccatcta gccctcagca ggccccgccg gctgtccaca gcggaccctg ctgatgcctc    720

caccatctat gcagttgtag tttga                                          745


<210>  1571
<211>  237
<212>  PRT
<213>  Homosapiens

<400>  1571

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Leu Ser Pro Pro His Ser Ser Thr Cys Glu Asn 
            180                 185                 190         


Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln Asp Ser Arg Gly 
        195                 200                 205             


Pro Gly Pro Gly Thr Glu Pro Ala Leu Cys Gly Ser Gly Pro Ser Ser 
    210                 215                 220                 


Pro Gln Gln Ala Pro Pro Ala Val His Ser Gly Pro Cys 
225                 230                 235         


<210>  1572
<211>  726
<212>  DNA
<213>  Homosapiens

<400>  1572
atggctgtgt ttctgcagct gctaccgctg ctgctctcga gggcccaagg gaaccctggg     60

gcttctctgg acggccgccc tggggaccgg gtgaatctct cctgcggagg agtctctcat    120

cccatccgct gggtctgggc acccagcttc ccggcctgca agggcctgtc caaaggacgc    180

cgaccgatcc tgtgggcctc ttcgagcggg acccccaccg tgcctcccct ccagcctttc    240

gtcggccgcc tacgctccct ggactctggt atccggcggc tggagctcct cttgagcgcg    300

ggagactcgg gcactttttt ctgcaagggc cgccacgagg acgagagccg tacagtgctt    360

cacgtgctgg gggacaggac ctattgcaag gcccccgggc ctacccatgg gtccgtgtat    420

ccccagctcc tgatcccgct gctgggcgct gggttggtgc tcggactggg agctttgggc    480

ctggtctggt ggctgcacag gcgcctgccc ccgcaaccga ttcgaccact ccctagattt    540

gctccacttg tgaaaaccga gccccagagg ccagtaaagg aggaagagcc caagattcca    600

ggggacctgg accaggaacc gagcctgctc tatgcggatc tggaccatct agccctcagc    660

aggccccgcc ggctgtccac agcggaccct gctgatgcct ccaccatcta tgcagttgta    720

gtttga                                                               726


<210>  1573
<211>  241
<212>  PRT
<213>  Homosapiens

<400>  1573

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Pro Leu Val Lys Thr Glu Pro Gln Arg Pro Val 
            180                 185                 190         


Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp Gln Glu Pro Ser 
        195                 200                 205             


Leu Leu Tyr Ala Asp Leu Asp His Leu Ala Leu Ser Arg Pro Arg Arg 
    210                 215                 220                 


Leu Ser Thr Ala Asp Pro Ala Asp Ala Ser Thr Ile Tyr Ala Val Val 
225                 230                 235                 240 


Val 
    


<210>  1574
<211>  654
<212>  DNA
<213>  Homosapiens

<400>  1574
atggctgtgt ttctgcagct gctaccgctg ctgctctcga gggcccaagg gaaccctggg     60

gcttctctgg acggccgccc tggggaccgg gtgaatctct cctgcggagg agtctctcat    120

cccatccgct gggtctgggc acccagcttc ccggcctgca agggcctgtc caaaggacgc    180

cgaccgatcc tgtgggcctc ttcgagcggg acccccaccg tgcctcccct ccagcctttc    240

gtcggccgcc tacgctccct ggactctggt atccggcggc tggagctcct cttgagcgcg    300

ggagactcgg gcactttttt ctgcaagggc cgccacgagg acgagagccg tacagtgctt    360

cacgtgctgg gggacaggac ctattgcaag gcccccgggc ctacccatgg cgcctgcccc    420

cgcaaccgat tcgaccactc cctagatttg ctctgtcccc cccacatagc tccacttgtg    480

aaaaccgagc cccagaggcc agtaaaggag gaagagccca agattccagg ggacctggac    540

caggaaccga gcctgctcta tgcggatctg gaccatctag ccctcagcag gccccgccgg    600

ctgtccacag cggaccctgc tgatgcctcc accatctatg cagttgtagt ttga          654


<210>  1575
<211>  217
<212>  PRT
<213>  Homosapiens

<400>  1575

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ala Cys Pro Arg Asn Arg Phe 
    130                 135                 140                 


Asp His Ser Leu Asp Leu Leu Cys Pro Pro His Ile Ala Pro Leu Val 
145                 150                 155                 160 


Lys Thr Glu Pro Gln Arg Pro Val Lys Glu Glu Glu Pro Lys Ile Pro 
                165                 170                 175     


Gly Asp Leu Asp Gln Glu Pro Ser Leu Leu Tyr Ala Asp Leu Asp His 
            180                 185                 190         


Leu Ala Leu Ser Arg Pro Arg Arg Leu Ser Thr Ala Asp Pro Ala Asp 
        195                 200                 205             


Ala Ser Thr Ile Tyr Ala Val Val Val 
    210                 215         


<210>  1576
<211>  613
<212>  DNA
<213>  Homosapiens

<400>  1576
atggctgtgt ttctgcagct gctaccgctg ctgctctcga gggcccaagg gaaccctggg     60

gcttctctgg acggccgccc tggggaccgg gtgaatctct cctgcggagg agtctctcat    120

cccatccgct gggtctgggc acccagcttc ccggcctgca agggcctgtc caaaggacgc    180

cgaccgatcc tgtgggcctc ttcgagcggg acccccaccg tgcctcccct ccagcctttc    240

gtcggccgcc tacgctccct ggactctggt atccggcggc tggagctcct cttgagcgcg    300

ggagactcgg gcactttttt ctgcaagggc cgccacgagg acgagagccg tacagtgctt    360

cacgtgctgg gggacaggac ctattgcaag gcccccgggc ctacccatgc tctgtccccc    420

ccacatagct ccacttgtga aaaccgagcc ccagaggcca gtaaaggagg aagagcccaa    480

gattccaggg gacctggacc aggaaccgag cctgctctat gcggatctgg accatctagc    540

cctcagcagg ccccgccggc tgtccacagc ggaccctgct gatgcctcca ccatctatgc    600

agttgtagtt tga                                                       613


<210>  1577
<211>  193
<212>  PRT
<213>  Homosapiens

<400>  1577

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Ala Leu Ser Pro Pro His Ser Ser 
    130                 135                 140                 


Thr Cys Glu Asn Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln 
145                 150                 155                 160 


Asp Ser Arg Gly Pro Gly Pro Gly Thr Glu Pro Ala Leu Cys Gly Ser 
                165                 170                 175     


Gly Pro Ser Ser Pro Gln Gln Ala Pro Pro Ala Val His Ser Gly Pro 
            180                 185                 190         


Cys 
    


<210>  1578
<211>  594
<212>  DNA
<213>  Homosapiens

<400>  1578
atggctgtgt ttctgcagct gctaccgctg ctgctctcga gggcccaagg gaaccctggg     60

gcttctctgg acggccgccc tggggaccgg gtgaatctct cctgcggagg agtctctcat    120

cccatccgct gggtctgggc acccagcttc ccggcctgca agggcctgtc caaaggacgc    180

cgaccgatcc tgtgggcctc ttcgagcggg acccccaccg tgcctcccct ccagcctttc    240

gtcggccgcc tacgctccct ggactctggt atccggcggc tggagctcct cttgagcgcg    300

ggagactcgg gcactttttt ctgcaagggc cgccacgagg acgagagccg tacagtgctt    360

cacgtgctgg gggacaggac ctattgcaag gcccccgggc ctacccatgc tccacttgtg    420

aaaaccgagc cccagaggcc agtaaaggag gaagagccca agattccagg ggacctggac    480

caggaaccga gcctgctcta tgcggatctg gaccatctag ccctcagcag gccccgccgg    540

ctgtccacag cggaccctgc tgatgcctcc accatctatg cagttgtagt ttga          594


<210>  1579
<211>  197
<212>  PRT
<213>  Homosapiens

<400>  1579

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Ala Pro Leu Val Lys Thr Glu Pro 
    130                 135                 140                 


Gln Arg Pro Val Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp 
145                 150                 155                 160 


Gln Glu Pro Ser Leu Leu Tyr Ala Asp Leu Asp His Leu Ala Leu Ser 
                165                 170                 175     


Arg Pro Arg Arg Leu Ser Thr Ala Asp Pro Ala Asp Ala Ser Thr Ile 
            180                 185                 190         


Tyr Ala Val Val Val 
        195         


<210>  1580
<211>  863
<212>  DNA
<213>  Homosapiens

<400>  1580
atggctgtgt ttctgcagct gctaccgctg ctgctctcga gggcccaagg gaaccctggg     60

gcttctctgg acggccgccc tggggaccgg gtgaatctct cctgcggagg agtctctcat    120

cccatccgct gggtctgggc acccagcttc ccggcctgca agggcctgtc caaaggacgc    180

cgaccgatcc tgtgggcctc ttcgagcggg acccccaccg tgcctcccct ccagcctttc    240

gtcggccgcc tacgctccct ggactctggt atccggcggc tggagctcct cttgagcgcg    300

ggagactcgg gcactttttt ctgcaagggc cgccacgagg acgagagccg tacagtgctt    360

cacgtgctgg gggacaggac ctattgcaag gcccccgggc ctacccatgg gtccgtgtat    420

ccccagctcc tgatcccgct gctgggcgct gggttggtgc tcggactggg agctttgggc    480

ctggtctggt ggctgcacag gcgcctgccc ccgcaaccga ttcgaccact ccctagattt    540

ggtgagacta attccacccc attttctttc tcctacatgc ccactcccca cccctcaatt    600

cctgagtctg agcccttgct gggagcagac acgttggtca ccttctctcc atccttcagc    660

tctgtccccc ccacatagct ccacttgtga aaaccgagcc ccagaggcca gtaaaggagg    720

aagagcccaa gattccaggg gacctggacc aggaaccgag cctgctctat gcggatctgg    780

accatctagc cctcagcagg ccccgccggc tgtccacagc ggaccctgct gatgcctcca    840

ccatctatgc agttgtagtt tga                                            863


<210>  1581
<211>  225
<212>  PRT
<213>  Homosapiens

<400>  1581

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Gly Glu Thr Asn Ser Thr Pro Phe Ser Phe Ser Tyr 
            180                 185                 190         


Met Pro Thr Pro His Pro Ser Ile Pro Glu Ser Glu Pro Leu Leu Gly 
        195                 200                 205             


Ala Asp Thr Leu Val Thr Phe Ser Pro Ser Phe Ser Ser Val Pro Pro 
    210                 215                 220                 


Thr 
225 


<210>  1582
<211>  870
<212>  DNA
<213>  Homosapiens

<400>  1582
atggctgtgt ttctgcagct gctaccgctg ctgctctcga gggcccaagg gaaccctggg     60

gcttctctgg acggccgccc tggggaccgg gtgaatctct cctgcggagg agtctctcat    120

cccatccgct gggtctgggc acccagcttc ccggcctgca agggcctgtc caaaggacgc    180

cgaccgatcc tgtgggcctc ttcgagcggg acccccaccg tgcctcccct ccagcctttc    240

gtcggccgcc tacgctccct ggactctggt atccggcggc tggagctcct cttgagcgcg    300

ggagactcgg gcactttttt ctgcaagggc cgccacgagg acgagagccg tacagtgctt    360

cacgtgctgg gggacaggac ctattgcaag gcccccgggc ctacccatgg gtccgtgtat    420

ccccagctcc tgatcccgct gctgggcgct gggttggtgc tcggactggg agctttgggc    480

ctggtctggt ggctgcacag gcgcctgccc ccgcaaccga ttcgaccact ccctagattt    540

gctctgtccc ccccacatag ctccacttgt gaaaaccgag ccccagaggc cagtaaagga    600

ggaagagccc aagattccag gggacctgga ccaggaaccg gtaagggcat ggggatggga    660

aggggatagc cagaatctct gaggaaaatg gaccaaaaaa aaaaaggcct gaaccccaag    720

gaagactgtg gagaccatct tgtcttcctc cccttcctcc tccagagcct gctctatgcg    780

gatctggacc atctagccct cagcaggccc cgccggctgt ccacagcgga ccctgctgat    840

gcctccacca tctatgcagt tgtagtttga                                     870


<210>  1583
<211>  222
<212>  PRT
<213>  Homosapiens

<400>  1583

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Leu Ser Pro Pro His Ser Ser Thr Cys Glu Asn 
            180                 185                 190         


Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln Asp Ser Arg Gly 
        195                 200                 205             


Pro Gly Pro Gly Thr Gly Lys Gly Met Gly Met Gly Arg Gly 
    210                 215                 220         


<210>  1584
<211>  1351
<212>  DNA
<213>  Homosapiens

<400>  1584
ccgcttagac aatgccccgg agccgccaga ccgtcgcgcc cctgccccat cgtagtatat     60

gagctcgcct acacaaggac ccccgctaaa agccagagct cccagtcccc gaggcttgaa    120

gacggggact cccttctcca ccaactctgt cctcgggggg tggggcccca gccgagatca    180

cagcgcgaca ggagtggggg tggccgctgg agacaggtga agaaacaaga aaactaagaa    240

atccgagcgg ttggaggggg agtctgtgtg gatgggatgg ggacgccggg ggaggggctg    300

ggccgctgct cccatgccct gatccgggga gtcccagaga gcctggcgtc gggggaaggt    360

gcgggggctg gccttcccgc tctggatctg gccaaagctc aaagggagca cggggtgctg    420

ggaggtaaac tgaggcaacg actggggcta cagctgctag aactgccacc tgaggagtca    480

ttgccgctgg gaccgctgct tggcgacacg gccgtgatcc aaggggacac ggccctaatc    540

acgcggccct ggagccccgc tcgtaggcca gaggtcgatg gagtccgcaa agccctgcaa    600

gacctggggc tccgaattgt ggaaatagga gacgagaacg cgacgctgga tggcactgac    660

gttctcttca ccggccggga gtttttcgta ggcctctcca aatggaccaa tcaccgagga    720

gctgagatcg tggcggacac gttccgggac ttcgccgtct ccactgtgcc agtctcgggt    780

ccctcccacc tgcgcggtct ctgcggcatg gggggacctc gcactgttgt ggcaggcagc    840

agcgacgctg cccaaaaggc tgtccgggca atggcagtgc tgacagatca cccatatgcc    900

tccctgaccc tcccagatga cgcagctgct gactgcctct ttcttcgtcc tgggttgcct    960

ggtgtgcccc ctttcctcct gcaccgtgga ggtggggatc tgcccaacag ccaggaggca   1020

ctgcagaagc tctctgatgt caccctggta cctgtgtcct gctcagaact ggagaaggct   1080

ggcgccgggc tcagctccct ctgcttggtg ctcagcacac gcccccacag ctgagggcct   1140

ggccttgggg tactgctggc caggggtagg atagtatagg aagtagaagg ggaaggaggg   1200

ttagatagag aatgctgaat aggcagtagt tgggagagag cctcaatatt gggggagggg   1260

agagtgtagg gaaaaggatc cactgggtga atcctccctc tcagaaccaa taaaatagaa   1320

ttgacctttt aaaaaaaaaa aaaaaaaaaa a                                  1351


<210>  1585
<211>  285
<212>  PRT
<213>  Homosapiens

<400>  1585

Met Gly Thr Pro Gly Glu Gly Leu Gly Arg Cys Ser His Ala Leu Ile 
1               5                   10                  15      


Arg Gly Val Pro Glu Ser Leu Ala Ser Gly Glu Gly Ala Gly Ala Gly 
            20                  25                  30          


Leu Pro Ala Leu Asp Leu Ala Lys Ala Gln Arg Glu His Gly Val Leu 
        35                  40                  45              


Gly Gly Lys Leu Arg Gln Arg Leu Gly Leu Gln Leu Leu Glu Leu Pro 
    50                  55                  60                  


Pro Glu Glu Ser Leu Pro Leu Gly Pro Leu Leu Gly Asp Thr Ala Val 
65                  70                  75                  80  


Ile Gln Gly Asp Thr Ala Leu Ile Thr Arg Pro Trp Ser Pro Ala Arg 
                85                  90                  95      


Arg Pro Glu Val Asp Gly Val Arg Lys Ala Leu Gln Asp Leu Gly Leu 
            100                 105                 110         


Arg Ile Val Glu Ile Gly Asp Glu Asn Ala Thr Leu Asp Gly Thr Asp 
        115                 120                 125             


Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys Trp Thr 
    130                 135                 140                 


Asn His Arg Gly Ala Glu Ile Val Ala Asp Thr Phe Arg Asp Phe Ala 
145                 150                 155                 160 


Val Ser Thr Val Pro Val Ser Gly Pro Ser His Leu Arg Gly Leu Cys 
                165                 170                 175     


Gly Met Gly Gly Pro Arg Thr Val Val Ala Gly Ser Ser Asp Ala Ala 
            180                 185                 190         


Gln Lys Ala Val Arg Ala Met Ala Val Leu Thr Asp His Pro Tyr Ala 
        195                 200                 205             


Ser Leu Thr Leu Pro Asp Asp Ala Ala Ala Asp Cys Leu Phe Leu Arg 
    210                 215                 220                 


Pro Gly Leu Pro Gly Val Pro Pro Phe Leu Leu His Arg Gly Gly Gly 
225                 230                 235                 240 


Asp Leu Pro Asn Ser Gln Glu Ala Leu Gln Lys Leu Ser Asp Val Thr 
                245                 250                 255     


Leu Val Pro Val Ser Cys Ser Glu Leu Glu Lys Ala Gly Ala Gly Leu 
            260                 265                 270         


Ser Ser Leu Cys Leu Val Leu Ser Thr Arg Pro His Ser 
        275                 280                 285 


<210>  1586
<211>  1265
<212>  DNA
<213>  Homosapiens

<400>  1586
gttcagggcg gggccggtcg gtgagtcagc ggctctctga tccagcccgg gagaggaccg     60

agctggagga gctgggtgtg gggtgcgttg ggctggtggg gaggcctagt ttgggtgcaa    120

gtaggtctga ttgagcttgt gttgtgctga agggacagcc ctgggtctag gggagagagt    180

ccctgagtgt gagacccgcc ttccccggtc ccagcccctc ccagttcccc cagggacggc    240

cacttcctgg tccccgacgc aaccatggct gaagaacaac cgcaggtcga attgttcgtg    300

aaggctggca gtgatggggc caagattggg aactgcccat tctcccagag actgttcatg    360

gtactgtggc tcaagggagt caccttcaat gttaccaccg ttgacaccaa aaggcggacc    420

gagacagtgc agaagctgtg cccagggggg cagctcccat tcctgctgta tggcactgaa    480

gtgcacacag acaccaacaa gattgaggaa tttctggagg cagtgctgtg ccctcccagg    540

taccccaagc tggcagctct gaaccctgag tccaacacag ctgggctgga catatttgcc    600

aaattttctg cctacatcaa gaattcaaac ccagcactca atgacaatct ggagaaggga    660

ctcctgaaag ccctgaaggt tttagacaat tacttaacat cccccctccc agaagaagtg    720

gatgaaacca gtgctgaaga tgaaggtgtc tctcagagga agtttttgga tggcaacgag    780

ctcaccctgg ctgactgcaa cctgttgcca aagttacaca tagtacaggt ggtgtgtaag    840

aagtaccggg gattcaccat ccccgaggcc ttccggggag tgcatcggta cttgagcaat    900

gcctacgccc gggaagaatt cgcttccacc tgtccagatg atgaggagat cgagctcgcc    960

tatgagcaag tggcaaaggc cctcaaataa gcccctcctg ggactccctc aaccccctcc   1020

attttctcca caaaggccct ggtggtttcc acattgctac ccaatggaca cactccaaaa   1080

tggccagtgg gcagggaatc ctggagcact tgttccggga tggtgtggtg gaagagggga   1140

tgagggaaag aaatgggggg cctgggtcag atttttattg tggggtggga tgagtaggac   1200

aacatatttc agtaataaaa tacagaataa aaatcaagtg tttttacgca aaaaaaaaaa   1260

aaaaa                                                               1265


<210>  1587
<211>  241
<212>  PRT
<213>  Homosapiens

<400>  1587

Met Ala Glu Glu Gln Pro Gln Val Glu Leu Phe Val Lys Ala Gly Ser 
1               5                   10                  15      


Asp Gly Ala Lys Ile Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met 
            20                  25                  30          


Val Leu Trp Leu Lys Gly Val Thr Phe Asn Val Thr Thr Val Asp Thr 
        35                  40                  45              


Lys Arg Arg Thr Glu Thr Val Gln Lys Leu Cys Pro Gly Gly Gln Leu 
    50                  55                  60                  


Pro Phe Leu Leu Tyr Gly Thr Glu Val His Thr Asp Thr Asn Lys Ile 
65                  70                  75                  80  


Glu Glu Phe Leu Glu Ala Val Leu Cys Pro Pro Arg Tyr Pro Lys Leu 
                85                  90                  95      


Ala Ala Leu Asn Pro Glu Ser Asn Thr Ala Gly Leu Asp Ile Phe Ala 
            100                 105                 110         


Lys Phe Ser Ala Tyr Ile Lys Asn Ser Asn Pro Ala Leu Asn Asp Asn 
        115                 120                 125             


Leu Glu Lys Gly Leu Leu Lys Ala Leu Lys Val Leu Asp Asn Tyr Leu 
    130                 135                 140                 


Thr Ser Pro Leu Pro Glu Glu Val Asp Glu Thr Ser Ala Glu Asp Glu 
145                 150                 155                 160 


Gly Val Ser Gln Arg Lys Phe Leu Asp Gly Asn Glu Leu Thr Leu Ala 
                165                 170                 175     


Asp Cys Asn Leu Leu Pro Lys Leu His Ile Val Gln Val Val Cys Lys 
            180                 185                 190         


Lys Tyr Arg Gly Phe Thr Ile Pro Glu Ala Phe Arg Gly Val His Arg 
        195                 200                 205             


Tyr Leu Ser Asn Ala Tyr Ala Arg Glu Glu Phe Ala Ser Thr Cys Pro 
    210                 215                 220                 


Asp Asp Glu Glu Ile Glu Leu Ala Tyr Glu Gln Val Ala Lys Ala Leu 
225                 230                 235                 240 


Lys 
    


<210>  1588
<211>  2903
<212>  DNA
<213>  Homosapiens

<400>  1588
gcgcgctcct tttgcaggct cgtggcggtc ggtcagcggg gcgttctccc acctgtagcg     60

actcaggtta ctgaaaaggc gggaaaacgc tgcgatggcg gcagctgggg gaggaggaag    120

ataagcgcgt gaggctgggg tcctggcgcg tggttggcag aggcagagac ataagacgtg    180

cacgactcgc cccacagggc cctcagaccc cttccttcca aaggagcctc caagctcatg    240

gcctccttag gagcgaaccc aaggaggaca ccgcagggac cgagacctgg ggcggcctcc    300

tccggcttcc ccagcccggc cccagtgccg ggccccaggg aggccgagga ggaggaagtc    360

gaggaggagg aggagctggc cgagatccat ctgtgtgtgc tgtggaattc aggatacttg    420

ggcattgcct actatgatac tagtgactcc actatccact tcatgccaga tgccccagac    480

cacgagagcc tcaagcttct ccagagagtt ctggatgaga tcaatcccca gtctgttgtt    540

acgagtgcca aacaggatga gaatatgact cgatttctgg gaaagcttgc ctcccaggag    600

cacagagagc ctaaaagacc tgaaatcata tttttgccaa gtgtggattt tggtctggag    660

ataagcaaac aacgcctcct ttctggaaac tactccttca tcccagacgc catgactgcc    720

actgagaaaa tcctcttcct ctcttccatt attccctttg actgcctcct cacagttcga    780

gcacttggag ggctgctgaa gttcctgggt cgaagaagaa tcggggttga actggaagac    840

tataatgtca gcgtccccat cctgggcttt aagaaattta tgttgactca tctggtgaac    900

atagatcaag acacttacag tgttctacag atttttaaga gtgagtctca cccctcagtg    960

tacaaagtgg ccagtggact gaaggagggg ctcagcctct ttggaatcct caacagatgc   1020

cactgtaagt ggggagagaa gctgctcagg ctatggttca cacgtccgac tcatgacctg   1080

ggggagctca gttctcgtct ggacgtcatt cagttttttc tgctgcccca gaatctggac   1140

atggctcaga tgctgcatcg gctcctgggt cacatcaaga acgtgcctct gattctgaaa   1200

cgcatgaagt tgtcccacac caaggtcagc gactggcagg ttctctacaa gactgtgtac   1260

agtgccctgg gcctgaggga tgcctgccgc tccctgccgc agtccatcca gctctttcgg   1320

gacattgccc aagagttctc tgatgacctg caccatatcg ccagcctcat tgggaaagta   1380

gtggactttg agggcagcct tgctgaaaat cgcttcacag tcctccccaa catagatcct   1440

gaaattgatg agaaaaagcg aagactgatg ggacttccca gtttccttac tgaggttgcc   1500

cgcaaggagc tggagaatct ggactcccgt attccttcat gcagtgtcat ctacatccct   1560

ctgattggct tccttctttc tattccccgc ctgccttcca tggtagaggc cagtgacttt   1620

gagattaatg gactggactt catgtttctc tcagaggaga agctgcacta tcgtagtgcc   1680

cgaaccaagg agctggatgc attgctgggg gacctgcact gcgagatccg ggaccaggag   1740

acgctgctga tgtaccagct acagtgccag gtgctggcac gagcagctgt cttaacccga   1800

gtattggacc ttgcctcccg cctggacgtc ctgctggctc ttgccagtgc tgcccgggac   1860

tatggctact caaggccgcg ttactcccca caagtccttg gggtacgaat ccagaatggc   1920

agacatcctc tgatggaact ctgtgcccga acctttgtgc ccaactccac agaatgtggt   1980

ggggacaaag ggagggtcaa agtcatcact ggacccaact catcagggaa gagcatatac   2040

ctcaaacagg taggcttgat cacattcatg gccctggtag gcagctttgt gccagcagag   2100

gaggccgaaa ttggggcagt agacgccatc ttcacacgaa ttcatagctg cgaatccatc   2160

tcccttggcc tctccacctt catgatcgac ctcaaccagg tggcgaaagc agtgaacaat   2220

gccactgcac agtcgctggt ccttattgat gaatttggaa agggaaccaa cacggtggat   2280

gggctcgcgc ttctggccgc tgtgctccga cactggctgg cacgtggacc cacatgcccc   2340

cacatctttg tggccaccaa ctttctgagc cttgttcagc tacaactgct gccacaaggg   2400

cccctggtgc agtatttgac catggagacc tgtgaggatg gcaacgatct tgtcttcttc   2460

tatcaggttt gcgaaggtgt tgcgaaggcc agccatgcct cccacacagc tgcccaggct   2520

gggcttcctg acaagcttgt ggctcgtggc aaggaggtct cagacttgat ccgcagtgga   2580

aaacccatca agcctgtcaa ggatttgcta aagaagaacc aaatggaaaa ttgccagaca   2640

ttagtggata agtttatgaa actggatttg gaagatccta acctggactt gaacgttttc   2700

atgagccagg aagtgctgcc tgctgccacc agcatcctct gagagtcctt ccagtgtcct   2760

ccccagcctc ctgagactcc ggtgggctgc catgccctct ttgtttcctt atctccctca   2820

gacgcagagt ttttagtttc tctagaaatt ttgtttcata ttaggaataa agtttatttt   2880

gaagaaaaaa aaaaaaaaaa aaa                                           2903


<210>  1589
<211>  834
<212>  PRT
<213>  Homosapiens

<400>  1589

Met Ala Ser Leu Gly Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg 
1               5                   10                  15      


Pro Gly Ala Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val Pro Gly 
            20                  25                  30          


Pro Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Leu Ala 
        35                  40                  45              


Glu Ile His Leu Cys Val Leu Trp Asn Ser Gly Tyr Leu Gly Ile Ala 
    50                  55                  60                  


Tyr Tyr Asp Thr Ser Asp Ser Thr Ile His Phe Met Pro Asp Ala Pro 
65                  70                  75                  80  


Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu Asp Glu Ile Asn 
                85                  90                  95      


Pro Gln Ser Val Val Thr Ser Ala Lys Gln Asp Glu Asn Met Thr Arg 
            100                 105                 110         


Phe Leu Gly Lys Leu Ala Ser Gln Glu His Arg Glu Pro Lys Arg Pro 
        115                 120                 125             


Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu Glu Ile Ser Lys 
    130                 135                 140                 


Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met Thr 
145                 150                 155                 160 


Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys 
                165                 170                 175     


Leu Leu Thr Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly Arg 
            180                 185                 190         


Arg Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val Pro Ile 
        195                 200                 205             


Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val Asn Ile Asp Gln 
    210                 215                 220                 


Asp Thr Tyr Ser Val Leu Gln Ile Phe Lys Ser Glu Ser His Pro Ser 
225                 230                 235                 240 


Val Tyr Lys Val Ala Ser Gly Leu Lys Glu Gly Leu Ser Leu Phe Gly 
                245                 250                 255     


Ile Leu Asn Arg Cys His Cys Lys Trp Gly Glu Lys Leu Leu Arg Leu 
            260                 265                 270         


Trp Phe Thr Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser Arg Leu 
        275                 280                 285             


Asp Val Ile Gln Phe Phe Leu Leu Pro Gln Asn Leu Asp Met Ala Gln 
    290                 295                 300                 


Met Leu His Arg Leu Leu Gly His Ile Lys Asn Val Pro Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Met Lys Leu Ser His Thr Lys Val Ser Asp Trp Gln Val Leu 
                325                 330                 335     


Tyr Lys Thr Val Tyr Ser Ala Leu Gly Leu Arg Asp Ala Cys Arg Ser 
            340                 345                 350         


Leu Pro Gln Ser Ile Gln Leu Phe Arg Asp Ile Ala Gln Glu Phe Ser 
        355                 360                 365             


Asp Asp Leu His His Ile Ala Ser Leu Ile Gly Lys Val Val Asp Phe 
    370                 375                 380                 


Glu Gly Ser Leu Ala Glu Asn Arg Phe Thr Val Leu Pro Asn Ile Asp 
385                 390                 395                 400 


Pro Glu Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu Pro Ser Phe 
                405                 410                 415     


Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn Leu Asp Ser Arg Ile 
            420                 425                 430         


Pro Ser Cys Ser Val Ile Tyr Ile Pro Leu Ile Gly Phe Leu Leu Ser 
        435                 440                 445             


Ile Pro Arg Leu Pro Ser Met Val Glu Ala Ser Asp Phe Glu Ile Asn 
    450                 455                 460                 


Gly Leu Asp Phe Met Phe Leu Ser Glu Glu Lys Leu His Tyr Arg Ser 
465                 470                 475                 480 


Ala Arg Thr Lys Glu Leu Asp Ala Leu Leu Gly Asp Leu His Cys Glu 
                485                 490                 495     


Ile Arg Asp Gln Glu Thr Leu Leu Met Tyr Gln Leu Gln Cys Gln Val 
            500                 505                 510         


Leu Ala Arg Ala Ala Val Leu Thr Arg Val Leu Asp Leu Ala Ser Arg 
        515                 520                 525             


Leu Asp Val Leu Leu Ala Leu Ala Ser Ala Ala Arg Asp Tyr Gly Tyr 
    530                 535                 540                 


Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly Val Arg Ile Gln Asn 
545                 550                 555                 560 


Gly Arg His Pro Leu Met Glu Leu Cys Ala Arg Thr Phe Val Pro Asn 
                565                 570                 575     


Ser Thr Glu Cys Gly Gly Asp Lys Gly Arg Val Lys Val Ile Thr Gly 
            580                 585                 590         


Pro Asn Ser Ser Gly Lys Ser Ile Tyr Leu Lys Gln Val Gly Leu Ile 
        595                 600                 605             


Thr Phe Met Ala Leu Val Gly Ser Phe Val Pro Ala Glu Glu Ala Glu 
    610                 615                 620                 


Ile Gly Ala Val Asp Ala Ile Phe Thr Arg Ile His Ser Cys Glu Ser 
625                 630                 635                 640 


Ile Ser Leu Gly Leu Ser Thr Phe Met Ile Asp Leu Asn Gln Val Ala 
                645                 650                 655     


Lys Ala Val Asn Asn Ala Thr Ala Gln Ser Leu Val Leu Ile Asp Glu 
            660                 665                 670         


Phe Gly Lys Gly Thr Asn Thr Val Asp Gly Leu Ala Leu Leu Ala Ala 
        675                 680                 685             


Val Leu Arg His Trp Leu Ala Arg Gly Pro Thr Cys Pro His Ile Phe 
    690                 695                 700                 


Val Ala Thr Asn Phe Leu Ser Leu Val Gln Leu Gln Leu Leu Pro Gln 
705                 710                 715                 720 


Gly Pro Leu Val Gln Tyr Leu Thr Met Glu Thr Cys Glu Asp Gly Asn 
                725                 730                 735     


Asp Leu Val Phe Phe Tyr Gln Val Cys Glu Gly Val Ala Lys Ala Ser 
            740                 745                 750         


His Ala Ser His Thr Ala Ala Gln Ala Gly Leu Pro Asp Lys Leu Val 
        755                 760                 765             


Ala Arg Gly Lys Glu Val Ser Asp Leu Ile Arg Ser Gly Lys Pro Ile 
    770                 775                 780                 


Lys Pro Val Lys Asp Leu Leu Lys Lys Asn Gln Met Glu Asn Cys Gln 
785                 790                 795                 800 


Thr Leu Val Asp Lys Phe Met Lys Leu Asp Leu Glu Asp Pro Asn Leu 
                805                 810                 815     


Asp Leu Asn Val Phe Met Ser Gln Glu Val Leu Pro Ala Ala Thr Ser 
            820                 825                 830         


Ile Leu 
        


<210>  1590
<211>  2796
<212>  DNA
<213>  Homosapiens

<400>  1590
gcgcgctcct tttgcaggct cgtggcggtc ggtcagcggg gcgttctccc acctgtagcg     60

actcagagcc tccaagctca tggcctcctt aggagcgaac ccaaggagga caccgcaggg    120

accgagacct ggggcggcct cctccggctt ccccagcccg gccccagtgc cgggccccag    180

ggaggccgag gaggaggaag tcgaggagga ggaggagctg gccgagatcc atctgtgtgt    240

gctgtggaat tcaggatact tgggcattgc ctactatgat actagtgact ccactatcca    300

cttcatgcca gatgccccag accacgagag cctcaagctt ctccagagag ttctggatga    360

gatcaatccc cagtctgttg ttacgagtgc caaacaggat gagaatatga ctcgatttct    420

gggaaagctt gcctcccagg agcacagaga gcctaaaaga cctgaaatca tatttttgcc    480

aagtgtggat tttggtctgg agataagcaa acaacgcctc ctttctggaa actactcctt    540

catcccagac gccatgactg ccactgagaa aatcctcttc ctctcttcca ttattccctt    600

tgactgcctc ctcacacccc caggagattt aagatttacc ccgattccac tgctgatccc    660

ctcccaggtt cgagcacttg gagggctgct gaagttcctg ggtcgaagaa gaatcggggt    720

tgaactggaa gactataatg tcagcgtccc catcctgggc tttaagaaat ttatgttgac    780

tcatctggtg aacatagatc aagacactta cagtgttcta cagattttta agagtgagtc    840

tcacccctca gtgtacaaag tggccagtgg actgaaggag gggctcagcc tctttggaat    900

cctcaacaga tgccactgta agtggggaga gaagctgctc aggctatggt tcacacgtcc    960

gactcatgac ctgggggagc tcagttctcg tctggacgtc attcagtttt ttctgctgcc   1020

ccagaatctg gacatggctc agatgctgca tcggctcctg ggtcacatca agaacgtgcc   1080

tctgattctg aaacgcatga agttgtccca caccaaggtc agcgactggc aggttctcta   1140

caagactgtg tacagtgccc tgggcctgag ggatgcctgc cgctccctgc cgcagtccat   1200

ccagctcttt cgggacattg cccaagagtt ctctgatgac ctgcaccata tcgccagcct   1260

cattgggaaa gtagtggact ttgagggcag ccttgctgaa aatcgcttca cagtcctccc   1320

caacatagat cctgaaattg atgagaaaaa gcgaagactg atgggacttc ccagtttcct   1380

tactgaggtt gcccgcaagg agctggagaa tctggactcc cgtattcctt catgcagtgt   1440

catctacatc cctctgattg gcttccttct ttctattccc cgcctgcctt ccatggtaga   1500

ggccagtgac tttgagatta atggactgga cttcatgttt ctctcagagg agaagctgca   1560

ctatcgtagt gcccgaacca aggagctgga tgcattgctg ggggacctgc actgcgagat   1620

ccgggaccag gagacgctgc tgatgtacca gctacagtgc caggtgctgg cacgagcagc   1680

tgtcttaacc cgagtattgg accttgcctc ccgcctggac gtcctgctgg ctcttgccag   1740

tgctgcccgg gactatggct actcaaggcc gcgttactcc ccacaagtcc ttggggtacg   1800

aatccagaat ggcagacatc ctctgatgga actctgtgcc cgaacctttg tgcccaactc   1860

cacagaatgt ggtggggaca aagggagggt caaagtcatc actggaccca actcatcagg   1920

gaagagcata tacctcaaac aggtaggctt gatcacattc atggccctgg taggcagctt   1980

tgtgccagca gaggaggccg aaattggggc agtagacgcc atcttcacac gaattcatag   2040

ctgcgaatcc atctcccttg gcctctccac cttcatgatc gacctcaacc aggtggcgaa   2100

agcagtgaac aatgccactg cacagtcgct ggtccttatt gatgaatttg gaaagggaac   2160

caacacggtg gatgggctcg cgcttctggc cgctgtgctc cgacactggc tggcacgtgg   2220

acccacatgc ccccacatct ttgtggccac caactttctg agccttgttc agctacaact   2280

gctgccacaa gggcccctgg tgcagtattt gaccatggag acctgtgagg atggcaacga   2340

tcttgtcttc ttctatcagg tttgcgaagg tgttgcgaag gccagccatg cctcccacac   2400

agctgcccag gctgggcttc ctgacaagct tgtggctcgt ggcaaggagg tctcagactt   2460

gatccgcagt ggaaaaccca tcaagcctgt caaggatttg ctaaagaaga accaaatgga   2520

aaattgccag acattagtgg ataagtttat gaaactggat ttggaagatc ctaacctgga   2580

cttgaacgtt ttcatgagcc aggaagtgct gcctgctgcc accagcatcc tctgagagtc   2640

cttccagtgt cctccccagc ctcctgagac tccggtgggc tgccatgccc tctttgtttc   2700

cttatctccc tcagacgcag agtttttagt ttctctagaa attttgtttc atattaggaa   2760

taaagtttat tttgaagaaa aaaaaaaaaa aaaaaa                             2796


<210>  1591
<211>  851
<212>  PRT
<213>  Homosapiens

<400>  1591

Met Ala Ser Leu Gly Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg 
1               5                   10                  15      


Pro Gly Ala Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val Pro Gly 
            20                  25                  30          


Pro Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Leu Ala 
        35                  40                  45              


Glu Ile His Leu Cys Val Leu Trp Asn Ser Gly Tyr Leu Gly Ile Ala 
    50                  55                  60                  


Tyr Tyr Asp Thr Ser Asp Ser Thr Ile His Phe Met Pro Asp Ala Pro 
65                  70                  75                  80  


Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu Asp Glu Ile Asn 
                85                  90                  95      


Pro Gln Ser Val Val Thr Ser Ala Lys Gln Asp Glu Asn Met Thr Arg 
            100                 105                 110         


Phe Leu Gly Lys Leu Ala Ser Gln Glu His Arg Glu Pro Lys Arg Pro 
        115                 120                 125             


Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu Glu Ile Ser Lys 
    130                 135                 140                 


Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met Thr 
145                 150                 155                 160 


Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys 
                165                 170                 175     


Leu Leu Thr Pro Pro Gly Asp Leu Arg Phe Thr Pro Ile Pro Leu Leu 
            180                 185                 190         


Ile Pro Ser Gln Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly 
        195                 200                 205             


Arg Arg Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val Pro 
    210                 215                 220                 


Ile Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val Asn Ile Asp 
225                 230                 235                 240 


Gln Asp Thr Tyr Ser Val Leu Gln Ile Phe Lys Ser Glu Ser His Pro 
                245                 250                 255     


Ser Val Tyr Lys Val Ala Ser Gly Leu Lys Glu Gly Leu Ser Leu Phe 
            260                 265                 270         


Gly Ile Leu Asn Arg Cys His Cys Lys Trp Gly Glu Lys Leu Leu Arg 
        275                 280                 285             


Leu Trp Phe Thr Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser Arg 
    290                 295                 300                 


Leu Asp Val Ile Gln Phe Phe Leu Leu Pro Gln Asn Leu Asp Met Ala 
305                 310                 315                 320 


Gln Met Leu His Arg Leu Leu Gly His Ile Lys Asn Val Pro Leu Ile 
                325                 330                 335     


Leu Lys Arg Met Lys Leu Ser His Thr Lys Val Ser Asp Trp Gln Val 
            340                 345                 350         


Leu Tyr Lys Thr Val Tyr Ser Ala Leu Gly Leu Arg Asp Ala Cys Arg 
        355                 360                 365             


Ser Leu Pro Gln Ser Ile Gln Leu Phe Arg Asp Ile Ala Gln Glu Phe 
    370                 375                 380                 


Ser Asp Asp Leu His His Ile Ala Ser Leu Ile Gly Lys Val Val Asp 
385                 390                 395                 400 


Phe Glu Gly Ser Leu Ala Glu Asn Arg Phe Thr Val Leu Pro Asn Ile 
                405                 410                 415     


Asp Pro Glu Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu Pro Ser 
            420                 425                 430         


Phe Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn Leu Asp Ser Arg 
        435                 440                 445             


Ile Pro Ser Cys Ser Val Ile Tyr Ile Pro Leu Ile Gly Phe Leu Leu 
    450                 455                 460                 


Ser Ile Pro Arg Leu Pro Ser Met Val Glu Ala Ser Asp Phe Glu Ile 
465                 470                 475                 480 


Asn Gly Leu Asp Phe Met Phe Leu Ser Glu Glu Lys Leu His Tyr Arg 
                485                 490                 495     


Ser Ala Arg Thr Lys Glu Leu Asp Ala Leu Leu Gly Asp Leu His Cys 
            500                 505                 510         


Glu Ile Arg Asp Gln Glu Thr Leu Leu Met Tyr Gln Leu Gln Cys Gln 
        515                 520                 525             


Val Leu Ala Arg Ala Ala Val Leu Thr Arg Val Leu Asp Leu Ala Ser 
    530                 535                 540                 


Arg Leu Asp Val Leu Leu Ala Leu Ala Ser Ala Ala Arg Asp Tyr Gly 
545                 550                 555                 560 


Tyr Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly Val Arg Ile Gln 
                565                 570                 575     


Asn Gly Arg His Pro Leu Met Glu Leu Cys Ala Arg Thr Phe Val Pro 
            580                 585                 590         


Asn Ser Thr Glu Cys Gly Gly Asp Lys Gly Arg Val Lys Val Ile Thr 
        595                 600                 605             


Gly Pro Asn Ser Ser Gly Lys Ser Ile Tyr Leu Lys Gln Val Gly Leu 
    610                 615                 620                 


Ile Thr Phe Met Ala Leu Val Gly Ser Phe Val Pro Ala Glu Glu Ala 
625                 630                 635                 640 


Glu Ile Gly Ala Val Asp Ala Ile Phe Thr Arg Ile His Ser Cys Glu 
                645                 650                 655     


Ser Ile Ser Leu Gly Leu Ser Thr Phe Met Ile Asp Leu Asn Gln Val 
            660                 665                 670         


Ala Lys Ala Val Asn Asn Ala Thr Ala Gln Ser Leu Val Leu Ile Asp 
        675                 680                 685             


Glu Phe Gly Lys Gly Thr Asn Thr Val Asp Gly Leu Ala Leu Leu Ala 
    690                 695                 700                 


Ala Val Leu Arg His Trp Leu Ala Arg Gly Pro Thr Cys Pro His Ile 
705                 710                 715                 720 


Phe Val Ala Thr Asn Phe Leu Ser Leu Val Gln Leu Gln Leu Leu Pro 
                725                 730                 735     


Gln Gly Pro Leu Val Gln Tyr Leu Thr Met Glu Thr Cys Glu Asp Gly 
            740                 745                 750         


Asn Asp Leu Val Phe Phe Tyr Gln Val Cys Glu Gly Val Ala Lys Ala 
        755                 760                 765             


Ser His Ala Ser His Thr Ala Ala Gln Ala Gly Leu Pro Asp Lys Leu 
    770                 775                 780                 


Val Ala Arg Gly Lys Glu Val Ser Asp Leu Ile Arg Ser Gly Lys Pro 
785                 790                 795                 800 


Ile Lys Pro Val Lys Asp Leu Leu Lys Lys Asn Gln Met Glu Asn Cys 
                805                 810                 815     


Gln Thr Leu Val Asp Lys Phe Met Lys Leu Asp Leu Glu Asp Pro Asn 
            820                 825                 830         


Leu Asp Leu Asn Val Phe Met Ser Gln Glu Val Leu Pro Ala Ala Thr 
        835                 840                 845             


Ser Ile Leu 
    850     


<210>  1592
<211>  2748
<212>  DNA
<213>  Homosapiens

<400>  1592
gcgcgctcct tttgcaggct cgtggcggtc ggtcagcggg gcgttctccc acctgtagcg     60

actcagagcc tccaagctca tggcctcctt aggagcgaac ccaaggagga caccgcaggg    120

accgagacct ggggcggcct cctccggctt ccccagcccg gccccagtgc cgggccccag    180

ggaggccgag gaggaggaag tcgaggagga ggaggagctg gccgagatcc atctgtgtgt    240

gctgtggaat tcaggatact tgggcattgc ctactatgat actagtgact ccactatcca    300

cttcatgcca gatgccccag accacgagag cctcaagctt ctccagagag ttctggatga    360

gatcaatccc cagtctgttg ttacgagtgc caaacaggat gagaatatga ctcgatttct    420

gggaaagctt gcctcccagg agcacagaga gcctaaaaga cctgaaatca tatttttgcc    480

aagtgtggat tttggtctgg agataagcaa acaacgcctc ctttctggaa actactcctt    540

catcccagac gccatgactg ccactgagaa aatcctcttc ctctcttcca ttattccctt    600

tgactgcctc ctcacagttc gagcacttgg agggctgctg aagttcctgg gtcgaagaag    660

aatcggggtt gaactggaag actataatgt cagcgtcccc atcctgggct ttaagaaatt    720

tatgttgact catctggtga acatagatca agacacttac agtgttctac agatttttaa    780

gagtgagtct cacccctcag tgtacaaagt ggccagtgga ctgaaggagg ggctcagcct    840

ctttggaatc ctcaacagat gccactgtaa gtggggagag aagctgctca ggctatggtt    900

cacacgtccg actcatgacc tgggggagct cagttctcgt ctggacgtca ttcagttttt    960

tctgctgccc cagaatctgg acatggctca gatgctgcat cggctcctgg gtcacatcaa   1020

gaacgtgcct ctgattctga aacgcatgaa gttgtcccac accaaggtca gcgactggca   1080

ggttctctac aagactgtgt acagtgccct gggcctgagg gatgcctgcc gctccctgcc   1140

gcagtccatc cagctctttc gggacattgc ccaagagttc tctgatgacc tgcaccatat   1200

cgccagcctc attgggaaag tagtggactt tgagggcagc cttgctgaaa atcgcttcac   1260

agtcctcccc aacatagatc ctgaaattga tgagaaaaag cgaagactga tgggacttcc   1320

cagtttcctt actgaggttg cccgcaagga gctggagaat ctggactccc gtattccttc   1380

atgcagtgtc atctacatcc ctctgattgg cttccttctt tctattcccc gcctgccttc   1440

catggtagag gccagtgact ttgagattaa tggactggac ttcatgtttc tctcagagga   1500

gaagctgcac tatcgtagtg cccgaaccaa ggagctggat gcattgctgg gggacctgca   1560

ctgcgagatc cgggaccagg agacgctgct gatgtaccag ctacagtgcc aggtgctggc   1620

acgagcagct gtcttaaccc gagtattgga ccttgcctcc cgcctggacg tcctgctggc   1680

tcttgccagt gctgcccggg actatggcta ctcaaggccg cgttactccc cacaagtcct   1740

tggggtacga atccagaatg gcagacatcc tctgatggaa ctctgtgccc gaacctttgt   1800

gcccaactcc acagaatgtg gtggggacaa agggagggtc aaagtcatca ctggacccaa   1860

ctcatcaggg aagagcatat acctcaaaca ggtaggcttg atcacattca tggccctggt   1920

aggcagcttt gtgccagcag aggaggccga aattggggca gtagacgcca tcttcacacg   1980

aattcatagc tgcgaatcca tctcccttgg cctctccacc ttcatgatcg acctcaacca   2040

gcaggtggcg aaagcagtga acaatgccac tgcacagtcg ctggtcctta ttgatgaatt   2100

tggaaaggga accaacacgg tggatgggct cgcgcttctg gccgctgtgc tccgacactg   2160

gctggcacgt ggacccacat gcccccacat ctttgtggcc accaactttc tgagccttgt   2220

tcagctacaa ctgctgccac aagggcccct ggtgcagtat ttgaccatgg agacctgtga   2280

ggatggcaac gatcttgtct tcttctatca ggtttgcgaa ggtgttgcga aggccagcca   2340

tgcctcccac acagctgccc aggctgggct tcctgacaag cttgtggctc gtggcaagga   2400

ggtctcagac ttgatccgca gtggaaaacc catcaagcct gtcaaggatt tgctaaagaa   2460

gaaccaaatg gaaaattgcc agacattagt ggataagttt atgaaactgg atttggaaga   2520

tcctaacctg gacttgaacg ttttcatgag ccaggaagtg ctgcctgctg ccaccagcat   2580

cctctgagag tccttccagt gtcctcccca gcctcctgag actccggtgg gctgccatgc   2640

cctctttgtt tccttatctc cctcagacgc agagttttta gtttctctag aaattttgtt   2700

tcatattagg aataaagttt attttgaaga aaaaaaaaaa aaaaaaaa                2748


<210>  1593
<211>  835
<212>  PRT
<213>  Homosapiens

<400>  1593

Met Ala Ser Leu Gly Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg 
1               5                   10                  15      


Pro Gly Ala Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val Pro Gly 
            20                  25                  30          


Pro Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Leu Ala 
        35                  40                  45              


Glu Ile His Leu Cys Val Leu Trp Asn Ser Gly Tyr Leu Gly Ile Ala 
    50                  55                  60                  


Tyr Tyr Asp Thr Ser Asp Ser Thr Ile His Phe Met Pro Asp Ala Pro 
65                  70                  75                  80  


Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu Asp Glu Ile Asn 
                85                  90                  95      


Pro Gln Ser Val Val Thr Ser Ala Lys Gln Asp Glu Asn Met Thr Arg 
            100                 105                 110         


Phe Leu Gly Lys Leu Ala Ser Gln Glu His Arg Glu Pro Lys Arg Pro 
        115                 120                 125             


Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu Glu Ile Ser Lys 
    130                 135                 140                 


Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met Thr 
145                 150                 155                 160 


Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys 
                165                 170                 175     


Leu Leu Thr Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly Arg 
            180                 185                 190         


Arg Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val Pro Ile 
        195                 200                 205             


Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val Asn Ile Asp Gln 
    210                 215                 220                 


Asp Thr Tyr Ser Val Leu Gln Ile Phe Lys Ser Glu Ser His Pro Ser 
225                 230                 235                 240 


Val Tyr Lys Val Ala Ser Gly Leu Lys Glu Gly Leu Ser Leu Phe Gly 
                245                 250                 255     


Ile Leu Asn Arg Cys His Cys Lys Trp Gly Glu Lys Leu Leu Arg Leu 
            260                 265                 270         


Trp Phe Thr Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser Arg Leu 
        275                 280                 285             


Asp Val Ile Gln Phe Phe Leu Leu Pro Gln Asn Leu Asp Met Ala Gln 
    290                 295                 300                 


Met Leu His Arg Leu Leu Gly His Ile Lys Asn Val Pro Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Met Lys Leu Ser His Thr Lys Val Ser Asp Trp Gln Val Leu 
                325                 330                 335     


Tyr Lys Thr Val Tyr Ser Ala Leu Gly Leu Arg Asp Ala Cys Arg Ser 
            340                 345                 350         


Leu Pro Gln Ser Ile Gln Leu Phe Arg Asp Ile Ala Gln Glu Phe Ser 
        355                 360                 365             


Asp Asp Leu His His Ile Ala Ser Leu Ile Gly Lys Val Val Asp Phe 
    370                 375                 380                 


Glu Gly Ser Leu Ala Glu Asn Arg Phe Thr Val Leu Pro Asn Ile Asp 
385                 390                 395                 400 


Pro Glu Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu Pro Ser Phe 
                405                 410                 415     


Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn Leu Asp Ser Arg Ile 
            420                 425                 430         


Pro Ser Cys Ser Val Ile Tyr Ile Pro Leu Ile Gly Phe Leu Leu Ser 
        435                 440                 445             


Ile Pro Arg Leu Pro Ser Met Val Glu Ala Ser Asp Phe Glu Ile Asn 
    450                 455                 460                 


Gly Leu Asp Phe Met Phe Leu Ser Glu Glu Lys Leu His Tyr Arg Ser 
465                 470                 475                 480 


Ala Arg Thr Lys Glu Leu Asp Ala Leu Leu Gly Asp Leu His Cys Glu 
                485                 490                 495     


Ile Arg Asp Gln Glu Thr Leu Leu Met Tyr Gln Leu Gln Cys Gln Val 
            500                 505                 510         


Leu Ala Arg Ala Ala Val Leu Thr Arg Val Leu Asp Leu Ala Ser Arg 
        515                 520                 525             


Leu Asp Val Leu Leu Ala Leu Ala Ser Ala Ala Arg Asp Tyr Gly Tyr 
    530                 535                 540                 


Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly Val Arg Ile Gln Asn 
545                 550                 555                 560 


Gly Arg His Pro Leu Met Glu Leu Cys Ala Arg Thr Phe Val Pro Asn 
                565                 570                 575     


Ser Thr Glu Cys Gly Gly Asp Lys Gly Arg Val Lys Val Ile Thr Gly 
            580                 585                 590         


Pro Asn Ser Ser Gly Lys Ser Ile Tyr Leu Lys Gln Val Gly Leu Ile 
        595                 600                 605             


Thr Phe Met Ala Leu Val Gly Ser Phe Val Pro Ala Glu Glu Ala Glu 
    610                 615                 620                 


Ile Gly Ala Val Asp Ala Ile Phe Thr Arg Ile His Ser Cys Glu Ser 
625                 630                 635                 640 


Ile Ser Leu Gly Leu Ser Thr Phe Met Ile Asp Leu Asn Gln Gln Val 
                645                 650                 655     


Ala Lys Ala Val Asn Asn Ala Thr Ala Gln Ser Leu Val Leu Ile Asp 
            660                 665                 670         


Glu Phe Gly Lys Gly Thr Asn Thr Val Asp Gly Leu Ala Leu Leu Ala 
        675                 680                 685             


Ala Val Leu Arg His Trp Leu Ala Arg Gly Pro Thr Cys Pro His Ile 
    690                 695                 700                 


Phe Val Ala Thr Asn Phe Leu Ser Leu Val Gln Leu Gln Leu Leu Pro 
705                 710                 715                 720 


Gln Gly Pro Leu Val Gln Tyr Leu Thr Met Glu Thr Cys Glu Asp Gly 
                725                 730                 735     


Asn Asp Leu Val Phe Phe Tyr Gln Val Cys Glu Gly Val Ala Lys Ala 
            740                 745                 750         


Ser His Ala Ser His Thr Ala Ala Gln Ala Gly Leu Pro Asp Lys Leu 
        755                 760                 765             


Val Ala Arg Gly Lys Glu Val Ser Asp Leu Ile Arg Ser Gly Lys Pro 
    770                 775                 780                 


Ile Lys Pro Val Lys Asp Leu Leu Lys Lys Asn Gln Met Glu Asn Cys 
785                 790                 795                 800 


Gln Thr Leu Val Asp Lys Phe Met Lys Leu Asp Leu Glu Asp Pro Asn 
                805                 810                 815     


Leu Asp Leu Asn Val Phe Met Ser Gln Glu Val Leu Pro Ala Ala Thr 
            820                 825                 830         


Ser Ile Leu 
        835 


<210>  1594
<211>  2745
<212>  DNA
<213>  Homosapiens

<400>  1594
gcgcgctcct tttgcaggct cgtggcggtc ggtcagcggg gcgttctccc acctgtagcg     60

actcagagcc tccaagctca tggcctcctt aggagcgaac ccaaggagga caccgcaggg    120

accgagacct ggggcggcct cctccggctt ccccagcccg gccccagtgc cgggccccag    180

ggaggccgag gaggaggaag tcgaggagga ggaggagctg gccgagatcc atctgtgtgt    240

gctgtggaat tcaggatact tgggcattgc ctactatgat actagtgact ccactatcca    300

cttcatgcca gatgccccag accacgagag cctcaagctt ctccagagag ttctggatga    360

gatcaatccc cagtctgttg ttacgagtgc caaacaggat gagaatatga ctcgatttct    420

gggaaagctt gcctcccagg agcacagaga gcctaaaaga cctgaaatca tatttttgcc    480

aagtgtggat tttggtctgg agataagcaa acaacgcctc ctttctggaa actactcctt    540

catcccagac gccatgactg ccactgagaa aatcctcttc ctctcttcca ttattccctt    600

tgactgcctc ctcacagttc gagcacttgg agggctgctg aagttcctgg gtcgaagaag    660

aatcggggtt gaactggaag actataatgt cagcgtcccc atcctgggct ttaagaaatt    720

tatgttgact catctggtga acatagatca agacacttac agtgttctac agatttttaa    780

gagtgagtct cacccctcag tgtacaaagt ggccagtgga ctgaaggagg ggctcagcct    840

ctttggaatc ctcaacagat gccactgtaa gtggggagag aagctgctca ggctatggtt    900

cacacgtccg actcatgacc tgggggagct cagttctcgt ctggacgtca ttcagttttt    960

tctgctgccc cagaatctgg acatggctca gatgctgcat cggctcctgg gtcacatcaa   1020

gaacgtgcct ctgattctga aacgcatgaa gttgtcccac accaaggtca gcgactggca   1080

ggttctctac aagactgtgt acagtgccct gggcctgagg gatgcctgcc gctccctgcc   1140

gcagtccatc cagctctttc gggacattgc ccaagagttc tctgatgacc tgcaccatat   1200

cgccagcctc attgggaaag tagtggactt tgagggcagc cttgctgaaa atcgcttcac   1260

agtcctcccc aacatagatc ctgaaattga tgagaaaaag cgaagactga tgggacttcc   1320

cagtttcctt actgaggttg cccgcaagga gctggagaat ctggactccc gtattccttc   1380

atgcagtgtc atctacatcc ctctgattgg cttccttctt tctattcccc gcctgccttc   1440

catggtagag gccagtgact ttgagattaa tggactggac ttcatgtttc tctcagagga   1500

gaagctgcac tatcgtagtg cccgaaccaa ggagctggat gcattgctgg gggacctgca   1560

ctgcgagatc cgggaccagg agacgctgct gatgtaccag ctacagtgcc aggtgctggc   1620

acgagcagct gtcttaaccc gagtattgga ccttgcctcc cgcctggacg tcctgctggc   1680

tcttgccagt gctgcccggg actatggcta ctcaaggccg cgttactccc cacaagtcct   1740

tggggtacga atccagaatg gcagacatcc tctgatggaa ctctgtgccc gaacctttgt   1800

gcccaactcc acagaatgtg gtggggacaa agggagggtc aaagtcatca ctggacccaa   1860

ctcatcaggg aagagcatat acctcaaaca ggtaggcttg atcacattca tggccctggt   1920

aggcagcttt gtgccagcag aggaggccga aattggggca gtagacgcca tcttcacacg   1980

aattcatagc tgcgaatcca tctcccttgg cctctccacc ttcatgatcg acctcaacca   2040

ggtggcgaaa gcagtgaaca atgccactgc acagtcgctg gtccttattg atgaatttgg   2100

aaagggaacc aacacggtgg atgggctcgc gcttctggcc gctgtgctcc gacactggct   2160

ggcacgtgga cccacatgcc cccacatctt tgtggccacc aactttctga gccttgttca   2220

gctacaactg ctgccacaag ggcccctggt gcagtatttg accatggaga cctgtgagga   2280

tggcaacgat cttgtcttct tctatcaggt ttgcgaaggt gttgcgaagg ccagccatgc   2340

ctcccacaca gctgcccagg ctgggcttcc tgacaagctt gtggctcgtg gcaaggaggt   2400

ctcagacttg atccgcagtg gaaaacccat caagcctgtc aaggatttgc taaagaagaa   2460

ccaaatggaa aattgccaga cattagtgga taagtttatg aaactggatt tggaagatcc   2520

taacctggac ttgaacgttt tcatgagcca ggaagtgctg cctgctgcca ccagcatcct   2580

ctgagagtcc ttccagtgtc ctccccagcc tcctgagact ccggtgggct gccatgccct   2640

ctttgtttcc ttatctccct cagacgcaga gtttttagtt tctctagaaa ttttgtttca   2700

tattaggaat aaagtttatt ttgaagaaaa aaaaaaaaaa aaaaa                   2745


<210>  1595
<211>  834
<212>  PRT
<213>  Homosapiens

<400>  1595

Met Ala Ser Leu Gly Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg 
1               5                   10                  15      


Pro Gly Ala Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val Pro Gly 
            20                  25                  30          


Pro Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Leu Ala 
        35                  40                  45              


Glu Ile His Leu Cys Val Leu Trp Asn Ser Gly Tyr Leu Gly Ile Ala 
    50                  55                  60                  


Tyr Tyr Asp Thr Ser Asp Ser Thr Ile His Phe Met Pro Asp Ala Pro 
65                  70                  75                  80  


Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu Asp Glu Ile Asn 
                85                  90                  95      


Pro Gln Ser Val Val Thr Ser Ala Lys Gln Asp Glu Asn Met Thr Arg 
            100                 105                 110         


Phe Leu Gly Lys Leu Ala Ser Gln Glu His Arg Glu Pro Lys Arg Pro 
        115                 120                 125             


Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu Glu Ile Ser Lys 
    130                 135                 140                 


Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met Thr 
145                 150                 155                 160 


Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys 
                165                 170                 175     


Leu Leu Thr Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly Arg 
            180                 185                 190         


Arg Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val Pro Ile 
        195                 200                 205             


Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val Asn Ile Asp Gln 
    210                 215                 220                 


Asp Thr Tyr Ser Val Leu Gln Ile Phe Lys Ser Glu Ser His Pro Ser 
225                 230                 235                 240 


Val Tyr Lys Val Ala Ser Gly Leu Lys Glu Gly Leu Ser Leu Phe Gly 
                245                 250                 255     


Ile Leu Asn Arg Cys His Cys Lys Trp Gly Glu Lys Leu Leu Arg Leu 
            260                 265                 270         


Trp Phe Thr Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser Arg Leu 
        275                 280                 285             


Asp Val Ile Gln Phe Phe Leu Leu Pro Gln Asn Leu Asp Met Ala Gln 
    290                 295                 300                 


Met Leu His Arg Leu Leu Gly His Ile Lys Asn Val Pro Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Met Lys Leu Ser His Thr Lys Val Ser Asp Trp Gln Val Leu 
                325                 330                 335     


Tyr Lys Thr Val Tyr Ser Ala Leu Gly Leu Arg Asp Ala Cys Arg Ser 
            340                 345                 350         


Leu Pro Gln Ser Ile Gln Leu Phe Arg Asp Ile Ala Gln Glu Phe Ser 
        355                 360                 365             


Asp Asp Leu His His Ile Ala Ser Leu Ile Gly Lys Val Val Asp Phe 
    370                 375                 380                 


Glu Gly Ser Leu Ala Glu Asn Arg Phe Thr Val Leu Pro Asn Ile Asp 
385                 390                 395                 400 


Pro Glu Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu Pro Ser Phe 
                405                 410                 415     


Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn Leu Asp Ser Arg Ile 
            420                 425                 430         


Pro Ser Cys Ser Val Ile Tyr Ile Pro Leu Ile Gly Phe Leu Leu Ser 
        435                 440                 445             


Ile Pro Arg Leu Pro Ser Met Val Glu Ala Ser Asp Phe Glu Ile Asn 
    450                 455                 460                 


Gly Leu Asp Phe Met Phe Leu Ser Glu Glu Lys Leu His Tyr Arg Ser 
465                 470                 475                 480 


Ala Arg Thr Lys Glu Leu Asp Ala Leu Leu Gly Asp Leu His Cys Glu 
                485                 490                 495     


Ile Arg Asp Gln Glu Thr Leu Leu Met Tyr Gln Leu Gln Cys Gln Val 
            500                 505                 510         


Leu Ala Arg Ala Ala Val Leu Thr Arg Val Leu Asp Leu Ala Ser Arg 
        515                 520                 525             


Leu Asp Val Leu Leu Ala Leu Ala Ser Ala Ala Arg Asp Tyr Gly Tyr 
    530                 535                 540                 


Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly Val Arg Ile Gln Asn 
545                 550                 555                 560 


Gly Arg His Pro Leu Met Glu Leu Cys Ala Arg Thr Phe Val Pro Asn 
                565                 570                 575     


Ser Thr Glu Cys Gly Gly Asp Lys Gly Arg Val Lys Val Ile Thr Gly 
            580                 585                 590         


Pro Asn Ser Ser Gly Lys Ser Ile Tyr Leu Lys Gln Val Gly Leu Ile 
        595                 600                 605             


Thr Phe Met Ala Leu Val Gly Ser Phe Val Pro Ala Glu Glu Ala Glu 
    610                 615                 620                 


Ile Gly Ala Val Asp Ala Ile Phe Thr Arg Ile His Ser Cys Glu Ser 
625                 630                 635                 640 


Ile Ser Leu Gly Leu Ser Thr Phe Met Ile Asp Leu Asn Gln Val Ala 
                645                 650                 655     


Lys Ala Val Asn Asn Ala Thr Ala Gln Ser Leu Val Leu Ile Asp Glu 
            660                 665                 670         


Phe Gly Lys Gly Thr Asn Thr Val Asp Gly Leu Ala Leu Leu Ala Ala 
        675                 680                 685             


Val Leu Arg His Trp Leu Ala Arg Gly Pro Thr Cys Pro His Ile Phe 
    690                 695                 700                 


Val Ala Thr Asn Phe Leu Ser Leu Val Gln Leu Gln Leu Leu Pro Gln 
705                 710                 715                 720 


Gly Pro Leu Val Gln Tyr Leu Thr Met Glu Thr Cys Glu Asp Gly Asn 
                725                 730                 735     


Asp Leu Val Phe Phe Tyr Gln Val Cys Glu Gly Val Ala Lys Ala Ser 
            740                 745                 750         


His Ala Ser His Thr Ala Ala Gln Ala Gly Leu Pro Asp Lys Leu Val 
        755                 760                 765             


Ala Arg Gly Lys Glu Val Ser Asp Leu Ile Arg Ser Gly Lys Pro Ile 
    770                 775                 780                 


Lys Pro Val Lys Asp Leu Leu Lys Lys Asn Gln Met Glu Asn Cys Gln 
785                 790                 795                 800 


Thr Leu Val Asp Lys Phe Met Lys Leu Asp Leu Glu Asp Pro Asn Leu 
                805                 810                 815     


Asp Leu Asn Val Phe Met Ser Gln Glu Val Leu Pro Ala Ala Thr Ser 
            820                 825                 830         


Ile Leu 
        


<210>  1596
<211>  2559
<212>  DNA
<213>  Homosapiens

<400>  1596
atgctcccca cggaggtccc ccaatcccac ccgggcccct cagcgttgct tctgctgcag     60

ctgttgctgc cccccacatc tgccttcttc cccaacatct ggagcctgct ggctgcccct    120

ggctccatca cccaccaaga cctaactgag gaggcagcgc tcaacgtcac cctgcagctc    180

ttcctggagc agccaccccc aggccgcccc cctcttcgtc ttgaggactt cctgggtcga    240

acactccttg ctgatgacct ctttgccgcc tactttggac ctggttcttc tcggcggttc    300

cgagcagcct taggtgaggt gtctcgtgcc aatgcagccc aggacttcct gccaacttcc    360

aggaatgacc ccgacctgca ctttgatgct gagcgactgg gtcagggacg cgcgcgcctg    420

gtaggggctc tgcgggagac cgtggtggca gccagggccc ttgaccacac cctggctcgc    480

cagcgcctcg gggctgcact tcatgccctg caggatttct acagtcatag caactgggtg    540

gagctgggcg agcagcagcc acaccctcac ctcctctggc caaggcagga gctccagaac    600

ctggcacaag tggccgatcc tacctgctcc gattgcgagg agttgagctg ccccaggaat    660

tggctgggct tcacactcct cacctctggc tactttggaa ctcatccccc gaaacctcca    720

gggaaatgta gccacggggg ccattttgac cggagcagct cccagccacc gaggggaggc    780

atcaacaagg acagcacatc cccaggcttc tcccctcacc acatgctgca cctccaggct    840

gcaaaactgg cccttctagc ctccatccag gccttcagcc ttctgcgaag ccgcctggga    900

gacagggatt tctccaggct gctggacatc accccagcct ccagcctgag ctttgtcctg    960

gacaccacgg gcagcatggg tgaggagatc aacgctgcca aaatccaggc tcgccacctt   1020

gtggagcagc ggagaggcag ccccatggag cctgtccact atgtcctggt gccttttcat   1080

gacccagggt tcggccctgt ctttacaacc agtgaccctg acagcttctg gcaacagctt   1140

aatgagatcc atgccttggg gggtggagac gagcctgaga tgtgcctgtc agccctgcag   1200

ctggccctgc tgcacacacc tccactctca gatatctttg tcttcacgga tgcctccccc   1260

aaggatgcct ttctcaccaa ccaggtggaa tccctgactc aggagcggcg ctgccgggta   1320

acattcctgg tgactgaaga tacatcaagg gttcagggtc gagctcggcg tgagatcttg   1380

tcccctctgc gttttgagcc atacaaagca gtggccctgg cctcaggagg agaggtgatc   1440

ttcaccaaag accagcacat tcgagacgtg gcagccattg ttggggagag catggctgcc   1500

ctggtgactc ttcccctgga ccctcctgtt gtggtgcctg ggcagccact tgtgttcagc   1560

gtggatgggc tgctccagaa gatcacagtc cggatccacg gagacatcag cagcttctgg   1620

atcaagaacc ctgcaggggt ctcccagggc caggaggaag gcgggggtcc tctaggtcac   1680

actcgccgct ttgggcagtt ctggatggtg accatggatg accctccaca gacaggaacc   1740

tgggagatcc aggtcacagc tgaggacacc cctggggtga gagtgcaagc ccagacctcc   1800

ctggacttcc tcttccactt tgggatcccc atggaggatg gaccccaccc tggcctctac   1860

cccctgactc agccagttgc aggtcttcag acccagctgc tggtagaagt gacagggttg   1920

ggttccagag ccaatcctgg ggatcctcag ccgcatttct cccacgtcat ccttcgaggg   1980

gtcccagagg gtgccgaact aggccaggtg cccttggagc ccgtgggacc tccggagcga   2040

ggtctcctcg cagcctcgct gtcgcccacg ctgctgtcca cccctagacc cttctccctg   2100

gagctgattg gccaggacgc agcggggcgg cgcctgcaca gggctgcccc tcagcctagc   2160

actgtagtcc ctgtccttct ggagcttagt ggcccctcgg gtttcttggc cccgggcagc   2220

aaagtcccgc tcagtctccg catcgccagc ttctcgggcc ctcaggatct tgaccttagg   2280

actttcgtca accccagctt ctccctcacc tccaacctct ccagggctca cctggaactg   2340

aatgagtcgg cctggggccg cctgtggctg gaggtcccag attcagcggc cccggattcc   2400

gtggtgatgg tgactgtgac tgcaggggga cgagaagcca acccagtacc cccgactcat   2460

gctttcctcc ggctcctggt atcggcccca gccccgcagg tgaggaacta ctactttcca   2520

tcacagggac cggcacacca cccctaccgg ctcatctga                          2559


<210>  1597
<211>  852
<212>  PRT
<213>  Homosapiens

<400>  1597

Met Leu Pro Thr Glu Val Pro Gln Ser His Pro Gly Pro Ser Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gln Leu Leu Leu Pro Pro Thr Ser Ala Phe Phe Pro Asn 
            20                  25                  30          


Ile Trp Ser Leu Leu Ala Ala Pro Gly Ser Ile Thr His Gln Asp Leu 
        35                  40                  45              


Thr Glu Glu Ala Ala Leu Asn Val Thr Leu Gln Leu Phe Leu Glu Gln 
    50                  55                  60                  


Pro Pro Pro Gly Arg Pro Pro Leu Arg Leu Glu Asp Phe Leu Gly Arg 
65                  70                  75                  80  


Thr Leu Leu Ala Asp Asp Leu Phe Ala Ala Tyr Phe Gly Pro Gly Ser 
                85                  90                  95      


Ser Arg Arg Phe Arg Ala Ala Leu Gly Glu Val Ser Arg Ala Asn Ala 
            100                 105                 110         


Ala Gln Asp Phe Leu Pro Thr Ser Arg Asn Asp Pro Asp Leu His Phe 
        115                 120                 125             


Asp Ala Glu Arg Leu Gly Gln Gly Arg Ala Arg Leu Val Gly Ala Leu 
    130                 135                 140                 


Arg Glu Thr Val Val Ala Ala Arg Ala Leu Asp His Thr Leu Ala Arg 
145                 150                 155                 160 


Gln Arg Leu Gly Ala Ala Leu His Ala Leu Gln Asp Phe Tyr Ser His 
                165                 170                 175     


Ser Asn Trp Val Glu Leu Gly Glu Gln Gln Pro His Pro His Leu Leu 
            180                 185                 190         


Trp Pro Arg Gln Glu Leu Gln Asn Leu Ala Gln Val Ala Asp Pro Thr 
        195                 200                 205             


Cys Ser Asp Cys Glu Glu Leu Ser Cys Pro Arg Asn Trp Leu Gly Phe 
    210                 215                 220                 


Thr Leu Leu Thr Ser Gly Tyr Phe Gly Thr His Pro Pro Lys Pro Pro 
225                 230                 235                 240 


Gly Lys Cys Ser His Gly Gly His Phe Asp Arg Ser Ser Ser Gln Pro 
                245                 250                 255     


Pro Arg Gly Gly Ile Asn Lys Asp Ser Thr Ser Pro Gly Phe Ser Pro 
            260                 265                 270         


His His Met Leu His Leu Gln Ala Ala Lys Leu Ala Leu Leu Ala Ser 
        275                 280                 285             


Ile Gln Ala Phe Ser Leu Leu Arg Ser Arg Leu Gly Asp Arg Asp Phe 
    290                 295                 300                 


Ser Arg Leu Leu Asp Ile Thr Pro Ala Ser Ser Leu Ser Phe Val Leu 
305                 310                 315                 320 


Asp Thr Thr Gly Ser Met Gly Glu Glu Ile Asn Ala Ala Lys Ile Gln 
                325                 330                 335     


Ala Arg His Leu Val Glu Gln Arg Arg Gly Ser Pro Met Glu Pro Val 
            340                 345                 350         


His Tyr Val Leu Val Pro Phe His Asp Pro Gly Phe Gly Pro Val Phe 
        355                 360                 365             


Thr Thr Ser Asp Pro Asp Ser Phe Trp Gln Gln Leu Asn Glu Ile His 
    370                 375                 380                 


Ala Leu Gly Gly Gly Asp Glu Pro Glu Met Cys Leu Ser Ala Leu Gln 
385                 390                 395                 400 


Leu Ala Leu Leu His Thr Pro Pro Leu Ser Asp Ile Phe Val Phe Thr 
                405                 410                 415     


Asp Ala Ser Pro Lys Asp Ala Phe Leu Thr Asn Gln Val Glu Ser Leu 
            420                 425                 430         


Thr Gln Glu Arg Arg Cys Arg Val Thr Phe Leu Val Thr Glu Asp Thr 
        435                 440                 445             


Ser Arg Val Gln Gly Arg Ala Arg Arg Glu Ile Leu Ser Pro Leu Arg 
    450                 455                 460                 


Phe Glu Pro Tyr Lys Ala Val Ala Leu Ala Ser Gly Gly Glu Val Ile 
465                 470                 475                 480 


Phe Thr Lys Asp Gln His Ile Arg Asp Val Ala Ala Ile Val Gly Glu 
                485                 490                 495     


Ser Met Ala Ala Leu Val Thr Leu Pro Leu Asp Pro Pro Val Val Val 
            500                 505                 510         


Pro Gly Gln Pro Leu Val Phe Ser Val Asp Gly Leu Leu Gln Lys Ile 
        515                 520                 525             


Thr Val Arg Ile His Gly Asp Ile Ser Ser Phe Trp Ile Lys Asn Pro 
    530                 535                 540                 


Ala Gly Val Ser Gln Gly Gln Glu Glu Gly Gly Gly Pro Leu Gly His 
545                 550                 555                 560 


Thr Arg Arg Phe Gly Gln Phe Trp Met Val Thr Met Asp Asp Pro Pro 
                565                 570                 575     


Gln Thr Gly Thr Trp Glu Ile Gln Val Thr Ala Glu Asp Thr Pro Gly 
            580                 585                 590         


Val Arg Val Gln Ala Gln Thr Ser Leu Asp Phe Leu Phe His Phe Gly 
        595                 600                 605             


Ile Pro Met Glu Asp Gly Pro His Pro Gly Leu Tyr Pro Leu Thr Gln 
    610                 615                 620                 


Pro Val Ala Gly Leu Gln Thr Gln Leu Leu Val Glu Val Thr Gly Leu 
625                 630                 635                 640 


Gly Ser Arg Ala Asn Pro Gly Asp Pro Gln Pro His Phe Ser His Val 
                645                 650                 655     


Ile Leu Arg Gly Val Pro Glu Gly Ala Glu Leu Gly Gln Val Pro Leu 
            660                 665                 670         


Glu Pro Val Gly Pro Pro Glu Arg Gly Leu Leu Ala Ala Ser Leu Ser 
        675                 680                 685             


Pro Thr Leu Leu Ser Thr Pro Arg Pro Phe Ser Leu Glu Leu Ile Gly 
    690                 695                 700                 


Gln Asp Ala Ala Gly Arg Arg Leu His Arg Ala Ala Pro Gln Pro Ser 
705                 710                 715                 720 


Thr Val Val Pro Val Leu Leu Glu Leu Ser Gly Pro Ser Gly Phe Leu 
                725                 730                 735     


Ala Pro Gly Ser Lys Val Pro Leu Ser Leu Arg Ile Ala Ser Phe Ser 
            740                 745                 750         


Gly Pro Gln Asp Leu Asp Leu Arg Thr Phe Val Asn Pro Ser Phe Ser 
        755                 760                 765             


Leu Thr Ser Asn Leu Ser Arg Ala His Leu Glu Leu Asn Glu Ser Ala 
    770                 775                 780                 


Trp Gly Arg Leu Trp Leu Glu Val Pro Asp Ser Ala Ala Pro Asp Ser 
785                 790                 795                 800 


Val Val Met Val Thr Val Thr Ala Gly Gly Arg Glu Ala Asn Pro Val 
                805                 810                 815     


Pro Pro Thr His Ala Phe Leu Arg Leu Leu Val Ser Ala Pro Ala Pro 
            820                 825                 830         


Gln Val Arg Asn Tyr Tyr Phe Pro Ser Gln Gly Pro Ala His His Pro 
        835                 840                 845             


Tyr Arg Leu Ile 
    850         


<210>  1598
<211>  4308
<212>  DNA
<213>  Homosapiens

<400>  1598
gcgcctgacg ggagcgtcgt gctcaggggt gtcctctcgt cctgcgtccg cgcccagcgc     60

cccgcgcccc gcgctgttcc tcgtgagacc ggcgggcggc gagccgcgcg gcccccgggg    120

cagtgtcgga cacggcgggc gcgcactcgc aggcggggca cggccgcccc cgccaggacc    180

cgcaggcccg gaaacgctcc ctgtcacaaa ggggggaaca cgtgggcgcc ggctgccggg    240

gcggcgatct tagggaacta gggtcacctg gagagccgcc caccgtctct gcccgctcga    300

ctcctccgcc cgggccgctc ggccggtcca gccgcggccg gcgcctggct gtgaggtgga    360

ttcccggccc agtctgacca tctccctcca gtttttccac ttcgttcgga ccttctcata    420

actatgtcca ccctctacgt ctcccctcac ccagatgcct tccccagcct ccgagccctc    480

atagccgctc gctatgggga ggctggggag ggtcccggat ggggaggagc ccacccccgc    540

atctgtctcc agccaccccc gactagcagg actccctttc ccccaccccg cctgccggcc    600

ctggagcagg ggcccggtgg gctctgggtg tggggggcca cggctgtggc ccagctgctg    660

tggccagcag gcctgggggg cccagggggc agccgggcgg ctgtccttgt ccaacagtgg    720

gtcagttacg ccgacacgga gttaatacca gctgcctgtg gagcaacgct gccggccctg    780

ggactccgaa gctcggccca ggacccccag gctgtgctgg gggccctggg cagggccctg    840

agccccttgg aggagtggct tcggctgcac acctacttgg ccggggaggc ccccactctg    900

gctgacctgg cggctgtcac agccttgctg ctgcctttcc gatacgtcct agacccacct    960

gcccgccgga tctggaataa tgtgactcgc tggtttgtca cgtgtgtccg gcagccagaa   1020

ttccgagccg tgctaggaga agtggttcta tactcaggag ccaggcctct ctctcatcag   1080

ccaggccccg aggctcctgc cctcccaaag acagctgctc agctcaagaa agaggcaaag   1140

aaacgggaga agctagagaa attccaacag aagcagaaga tccaacagca gcagccacct   1200

ccaggggaga agaaaccaaa accagagaag agggagaaac gggatcctgg ggtcattacc   1260

tatgacctcc caaccccacc cggggaaaag aaagatgtca gtggccccat gcccgactcc   1320

tacagccctc ggtatgtgga ggctgcctgg tacccttggt gggagcagca gggcttcttc   1380

aagccagagt atgggcgtcc taatgtgtca gcagcaaatc cccgaggtgt cttcatgatg   1440

tgcatcccac cccccaatgt gacaggctcc ctgcacctgg gccatgcact caccaacgcc   1500

atccaggact ccctgactcg atggcaccgc atgcgtgggg agaccaccct gtggaaccct   1560

ggctgtgacc atgcaggtat tgccacccag gtggtggtgg agaagaagct atggcgtgag   1620

cagggactga gccggcacca gctgggccgc gaggcctttc tacaggaagt ctggaagtgg   1680

aaggaggaga aaggtgaccg gatttaccac cagttgaaga agcttggcag ctccttggac   1740

tgggatcgag cctgtttcac catggaccct aaactctcag cagctgtgac agaggccttt   1800

gtccggcttc acgaggaagg catcatctat cgcagtaccc gccttgttaa ctggtcctgc   1860

accctcaact ccgccatctc tgacattgag gtggataaga aggagctgac aggtcgcacc   1920

ctgctctccg tgcctggcta caaggagaag gtggagttcg gggtcctcgt gtcctttgcc   1980

tataaggtcc aaggctcaga tagcgacgag gaggtggtgg tggcaacaac tcggatcgag   2040

acaatgctgg gagatgtggc tgtagctgtg caccccaaag ataccagata ccagcacctg   2100

aaggggaaga acgtgatcca cccattcctg tctcggagcc ttcccattgt cttcgatgaa   2160

tttgtggaca tggactttgg cacaggtgct gtgaagatca cccccgcaca tgaccaaaat   2220

gactatgaag ttgggcagcg gcacgggctg gaggccatca gcatcatgga ctcccggggg   2280

gccctcatca atgtgcctcc gcctttcctg ggcctgccca ggtttgaggc caggaaagcg   2340

gtgctggtgg cgctgaagga gcggggactg ttccgtggca ttgaggacaa ccccatggtg   2400

gtgccacttt gcaaccggtc gaaggacgtg gtagagcctc tgctgcggcc gcagtggtac   2460

gttcgctgcg gggagatggc ccaggctgcc agcgccgctg tgactcgggg tgacctccgc   2520

atcctgcctg aggcccatca gcgcacatgg catgcctgga tggacaacat ccgggagtgg   2580

tgcatttcca ggcagctgtg gtggggccat cgcatcccag cctactttgt cactgtcagt   2640

gacccagcgg tgccccctgg ggaggaccct gatgggcggt actgggtgag tggacgcaat   2700

gaggcggagg cccgggagaa ggcagccaag gagttcggag tgtcccctga caagatcagt   2760

ctccagcaag atgaggatgt attggatacc tggttctcct ctggcctctt ccccttatcc   2820

attttgggct ggcccaacca gtcagaagac ctgagtgtgt tctaccccgg gacactgctg   2880

gagaccggtc atgacatcct cttcttctgg gtggcccgga tggtcatgct gggcctgaag   2940

ctcacgggca ggctgccctt tagagaggtc tacctccatg ccatcgtgcg agatgctcac   3000

ggccggaaga tgagcaagtc tctaggcaat gtcatcgatc ccctggacgt catctatgga   3060

atctccctgc agggcctcca caaccagctg ctgaacagca acctggatcc cagcgaggtg   3120

gagaaggcca aagaagggca gaaagctgac ttcccagcgg ggattcctga atgtggcacc   3180

gatgctctcc ggtttggatt atgtgcctac atgtcccagg gtcgtgacat caacctggat   3240

gtgaaccgga tactgggtta ccgccacttc tgcaacaagc tctggaatgc caccaagttt   3300

gcccttcgtg gccttgggaa gggttttgtg ccctcaccca cctcccagcc cggaggccat   3360

gagagcctgg tggaccgctg gatccgcagc cgcctgacag aggctgtgag gctcagcaat   3420

caaggcttcc aggcctacga cttcccggcc gtcaccactg cccagtacag cttctggctc   3480

tatgagctct gtgatgtcta cttggagtgc ctgaaacctg tactgaatgg ggtggaccag   3540

gtggcagctg agtgtgcccg ccagaccctg tacacttgcc tggacgttgg cctgcggctg   3600

ctctcaccct tcatgccctt cgtgacggag gagctgttcc agaggctgcc ccggaggatg   3660

ccgcaagctc cccctagcct ctgtgttacc ccctacccgg agccctcaga gtgctcctgg   3720

aaggaccccg aggcagaagc cgcccttgag ctggcgctaa gcatcacgcg agccgtgcgc   3780

tccctgcggg ccgactacaa cctcacccgg atccggcctg actgtttcct ggaagtggcg   3840

gatgaggcca cgggcgccct ggcatcggcg gtgtcgggct acgtgcaggc cctggccagc   3900

gcaggtgtgg tggctgttct ggccctgggg gctcccgccc cccagggttg cgctgtggct   3960

ctggcttctg atcgctgctc catccacctg cagcttcagg ggctggtgga ccctgcacgg   4020

gagctgggca agctgcaagc caagcgagtt gaggcccagc ggcaggccca gcgtctgcgg   4080

gaacgccgtg ctgcctcggg ctatcctgtc aaggtgccgc tcgaagtcca ggaggcagat   4140

gaagccaagc tccaacagac agaagcagag ctcaggaagg tggatgaggc catcgcccta   4200

ttccagaaga tgctgtgatc caccacccag cttcacccct cacccccagc ggctcaccat   4260

ggggatggca gcaataaaat attttcccac aaaaaaaaaa aaaaaaaa                4308


<210>  1599
<211>  1264
<212>  PRT
<213>  Homosapiens

<400>  1599

Met Ser Thr Leu Tyr Val Ser Pro His Pro Asp Ala Phe Pro Ser Leu 
1               5                   10                  15      


Arg Ala Leu Ile Ala Ala Arg Tyr Gly Glu Ala Gly Glu Gly Pro Gly 
            20                  25                  30          


Trp Gly Gly Ala His Pro Arg Ile Cys Leu Gln Pro Pro Pro Thr Ser 
        35                  40                  45              


Arg Thr Pro Phe Pro Pro Pro Arg Leu Pro Ala Leu Glu Gln Gly Pro 
    50                  55                  60                  


Gly Gly Leu Trp Val Trp Gly Ala Thr Ala Val Ala Gln Leu Leu Trp 
65                  70                  75                  80  


Pro Ala Gly Leu Gly Gly Pro Gly Gly Ser Arg Ala Ala Val Leu Val 
                85                  90                  95      


Gln Gln Trp Val Ser Tyr Ala Asp Thr Glu Leu Ile Pro Ala Ala Cys 
            100                 105                 110         


Gly Ala Thr Leu Pro Ala Leu Gly Leu Arg Ser Ser Ala Gln Asp Pro 
        115                 120                 125             


Gln Ala Val Leu Gly Ala Leu Gly Arg Ala Leu Ser Pro Leu Glu Glu 
    130                 135                 140                 


Trp Leu Arg Leu His Thr Tyr Leu Ala Gly Glu Ala Pro Thr Leu Ala 
145                 150                 155                 160 


Asp Leu Ala Ala Val Thr Ala Leu Leu Leu Pro Phe Arg Tyr Val Leu 
                165                 170                 175     


Asp Pro Pro Ala Arg Arg Ile Trp Asn Asn Val Thr Arg Trp Phe Val 
            180                 185                 190         


Thr Cys Val Arg Gln Pro Glu Phe Arg Ala Val Leu Gly Glu Val Val 
        195                 200                 205             


Leu Tyr Ser Gly Ala Arg Pro Leu Ser His Gln Pro Gly Pro Glu Ala 
    210                 215                 220                 


Pro Ala Leu Pro Lys Thr Ala Ala Gln Leu Lys Lys Glu Ala Lys Lys 
225                 230                 235                 240 


Arg Glu Lys Leu Glu Lys Phe Gln Gln Lys Gln Lys Ile Gln Gln Gln 
                245                 250                 255     


Gln Pro Pro Pro Gly Glu Lys Lys Pro Lys Pro Glu Lys Arg Glu Lys 
            260                 265                 270         


Arg Asp Pro Gly Val Ile Thr Tyr Asp Leu Pro Thr Pro Pro Gly Glu 
        275                 280                 285             


Lys Lys Asp Val Ser Gly Pro Met Pro Asp Ser Tyr Ser Pro Arg Tyr 
    290                 295                 300                 


Val Glu Ala Ala Trp Tyr Pro Trp Trp Glu Gln Gln Gly Phe Phe Lys 
305                 310                 315                 320 


Pro Glu Tyr Gly Arg Pro Asn Val Ser Ala Ala Asn Pro Arg Gly Val 
                325                 330                 335     


Phe Met Met Cys Ile Pro Pro Pro Asn Val Thr Gly Ser Leu His Leu 
            340                 345                 350         


Gly His Ala Leu Thr Asn Ala Ile Gln Asp Ser Leu Thr Arg Trp His 
        355                 360                 365             


Arg Met Arg Gly Glu Thr Thr Leu Trp Asn Pro Gly Cys Asp His Ala 
    370                 375                 380                 


Gly Ile Ala Thr Gln Val Val Val Glu Lys Lys Leu Trp Arg Glu Gln 
385                 390                 395                 400 


Gly Leu Ser Arg His Gln Leu Gly Arg Glu Ala Phe Leu Gln Glu Val 
                405                 410                 415     


Trp Lys Trp Lys Glu Glu Lys Gly Asp Arg Ile Tyr His Gln Leu Lys 
            420                 425                 430         


Lys Leu Gly Ser Ser Leu Asp Trp Asp Arg Ala Cys Phe Thr Met Asp 
        435                 440                 445             


Pro Lys Leu Ser Ala Ala Val Thr Glu Ala Phe Val Arg Leu His Glu 
    450                 455                 460                 


Glu Gly Ile Ile Tyr Arg Ser Thr Arg Leu Val Asn Trp Ser Cys Thr 
465                 470                 475                 480 


Leu Asn Ser Ala Ile Ser Asp Ile Glu Val Asp Lys Lys Glu Leu Thr 
                485                 490                 495     


Gly Arg Thr Leu Leu Ser Val Pro Gly Tyr Lys Glu Lys Val Glu Phe 
            500                 505                 510         


Gly Val Leu Val Ser Phe Ala Tyr Lys Val Gln Gly Ser Asp Ser Asp 
        515                 520                 525             


Glu Glu Val Val Val Ala Thr Thr Arg Ile Glu Thr Met Leu Gly Asp 
    530                 535                 540                 


Val Ala Val Ala Val His Pro Lys Asp Thr Arg Tyr Gln His Leu Lys 
545                 550                 555                 560 


Gly Lys Asn Val Ile His Pro Phe Leu Ser Arg Ser Leu Pro Ile Val 
                565                 570                 575     


Phe Asp Glu Phe Val Asp Met Asp Phe Gly Thr Gly Ala Val Lys Ile 
            580                 585                 590         


Thr Pro Ala His Asp Gln Asn Asp Tyr Glu Val Gly Gln Arg His Gly 
        595                 600                 605             


Leu Glu Ala Ile Ser Ile Met Asp Ser Arg Gly Ala Leu Ile Asn Val 
    610                 615                 620                 


Pro Pro Pro Phe Leu Gly Leu Pro Arg Phe Glu Ala Arg Lys Ala Val 
625                 630                 635                 640 


Leu Val Ala Leu Lys Glu Arg Gly Leu Phe Arg Gly Ile Glu Asp Asn 
                645                 650                 655     


Pro Met Val Val Pro Leu Cys Asn Arg Ser Lys Asp Val Val Glu Pro 
            660                 665                 670         


Leu Leu Arg Pro Gln Trp Tyr Val Arg Cys Gly Glu Met Ala Gln Ala 
        675                 680                 685             


Ala Ser Ala Ala Val Thr Arg Gly Asp Leu Arg Ile Leu Pro Glu Ala 
    690                 695                 700                 


His Gln Arg Thr Trp His Ala Trp Met Asp Asn Ile Arg Glu Trp Cys 
705                 710                 715                 720 


Ile Ser Arg Gln Leu Trp Trp Gly His Arg Ile Pro Ala Tyr Phe Val 
                725                 730                 735     


Thr Val Ser Asp Pro Ala Val Pro Pro Gly Glu Asp Pro Asp Gly Arg 
            740                 745                 750         


Tyr Trp Val Ser Gly Arg Asn Glu Ala Glu Ala Arg Glu Lys Ala Ala 
        755                 760                 765             


Lys Glu Phe Gly Val Ser Pro Asp Lys Ile Ser Leu Gln Gln Asp Glu 
    770                 775                 780                 


Asp Val Leu Asp Thr Trp Phe Ser Ser Gly Leu Phe Pro Leu Ser Ile 
785                 790                 795                 800 


Leu Gly Trp Pro Asn Gln Ser Glu Asp Leu Ser Val Phe Tyr Pro Gly 
                805                 810                 815     


Thr Leu Leu Glu Thr Gly His Asp Ile Leu Phe Phe Trp Val Ala Arg 
            820                 825                 830         


Met Val Met Leu Gly Leu Lys Leu Thr Gly Arg Leu Pro Phe Arg Glu 
        835                 840                 845             


Val Tyr Leu His Ala Ile Val Arg Asp Ala His Gly Arg Lys Met Ser 
    850                 855                 860                 


Lys Ser Leu Gly Asn Val Ile Asp Pro Leu Asp Val Ile Tyr Gly Ile 
865                 870                 875                 880 


Ser Leu Gln Gly Leu His Asn Gln Leu Leu Asn Ser Asn Leu Asp Pro 
                885                 890                 895     


Ser Glu Val Glu Lys Ala Lys Glu Gly Gln Lys Ala Asp Phe Pro Ala 
            900                 905                 910         


Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe Gly Leu Cys Ala 
        915                 920                 925             


Tyr Met Ser Gln Gly Arg Asp Ile Asn Leu Asp Val Asn Arg Ile Leu 
    930                 935                 940                 


Gly Tyr Arg His Phe Cys Asn Lys Leu Trp Asn Ala Thr Lys Phe Ala 
945                 950                 955                 960 


Leu Arg Gly Leu Gly Lys Gly Phe Val Pro Ser Pro Thr Ser Gln Pro 
                965                 970                 975     


Gly Gly His Glu Ser Leu Val Asp Arg Trp Ile Arg Ser Arg Leu Thr 
            980                 985                 990         


Glu Ala Val Arg Leu Ser Asn Gln  Gly Phe Gln Ala Tyr  Asp Phe Pro 
        995                 1000                 1005             


Ala Val  Thr Thr Ala Gln Tyr  Ser Phe Trp Leu Tyr  Glu Leu Cys 
    1010                 1015                 1020             


Asp Val  Tyr Leu Glu Cys Leu  Lys Pro Val Leu Asn  Gly Val Asp 
    1025                 1030                 1035             


Gln Val  Ala Ala Glu Cys Ala  Arg Gln Thr Leu Tyr  Thr Cys Leu 
    1040                 1045                 1050             


Asp Val  Gly Leu Arg Leu Leu  Ser Pro Phe Met Pro  Phe Val Thr 
    1055                 1060                 1065             


Glu Glu  Leu Phe Gln Arg Leu  Pro Arg Arg Met Pro  Gln Ala Pro 
    1070                 1075                 1080             


Pro Ser  Leu Cys Val Thr Pro  Tyr Pro Glu Pro Ser  Glu Cys Ser 
    1085                 1090                 1095             


Trp Lys  Asp Pro Glu Ala Glu  Ala Ala Leu Glu Leu  Ala Leu Ser 
    1100                 1105                 1110             


Ile Thr  Arg Ala Val Arg Ser  Leu Arg Ala Asp Tyr  Asn Leu Thr 
    1115                 1120                 1125             


Arg Ile  Arg Pro Asp Cys Phe  Leu Glu Val Ala Asp  Glu Ala Thr 
    1130                 1135                 1140             


Gly Ala  Leu Ala Ser Ala Val  Ser Gly Tyr Val Gln  Ala Leu Ala 
    1145                 1150                 1155             


Ser Ala  Gly Val Val Ala Val  Leu Ala Leu Gly Ala  Pro Ala Pro 
    1160                 1165                 1170             


Gln Gly  Cys Ala Val Ala Leu  Ala Ser Asp Arg Cys  Ser Ile His 
    1175                 1180                 1185             


Leu Gln  Leu Gln Gly Leu Val  Asp Pro Ala Arg Glu  Leu Gly Lys 
    1190                 1195                 1200             


Leu Gln  Ala Lys Arg Val Glu  Ala Gln Arg Gln Ala  Gln Arg Leu 
    1205                 1210                 1215             


Arg Glu  Arg Arg Ala Ala Ser  Gly Tyr Pro Val Lys  Val Pro Leu 
    1220                 1225                 1230             


Glu Val  Gln Glu Ala Asp Glu  Ala Lys Leu Gln Gln  Thr Glu Ala 
    1235                 1240                 1245             


Glu Leu  Arg Lys Val Asp Glu  Ala Ile Ala Leu Phe  Gln Lys Met 
    1250                 1255                 1260             


Leu 
    


<210>  1600
<211>  907
<212>  DNA
<213>  Homosapiens

<400>  1600
ctcctctcta ctctacccag cttgcgctcc ccagccgcaa gtcggccgcg ctttgcccgt     60

cagcgcttgg agctttctgc gtcgcttccc gctgcgcctg cgcggtcccg cctcgcccca    120

cgcgcgggct cgcgcttcgg tttccccaga cctgctcgca gcaccctgct gtcttcccgg    180

tccggcccgc tgcccgcggc gccagcacca tgctcttcta ttcttttttc aagtcccttg    240

tgggcaagga tgtggtcgtg gaactaaaga atgacctgag catctgtgga accctccatt    300

ctgtggatca gtatctcaac atcaaactaa ctgacatcag tgtcacagac cctgagaaat    360

accctcacat gttatcagtg aagaactgct tcattcgggg ctcagtggtc cgatacgtgc    420

agctgccagc agatgaggtc gacacacagt tgctacagga tgcggcaagg aaggaagccc    480

tgcagcagaa acagtgatgg ctcctcctcc tcttcccctc cctctttcat tggtgaccca    540

taaccccaag tcccagccca gaacccctaa cccccaatac ttgaaggggt tttgtttttt    600

tactaatgat ggttttgtgg gtttttttta agggatgagt ggatgagagg agtaataggg    660

aacagctatc ctctcttgag aaggggagga taagtaggct gggaaacttc aaagccttcc    720

cagtccccag cacctgcctt tctcactact tctctggaga tggtaggaga gtttcctagg    780

tctttccagg gcagcatgtg attcatttgg ggatggaagg aatctgtccc gcatcgggaa    840

taaaatttat gatgcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    900

aaaaaaa                                                              907


<210>  1601
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  1601

Met Leu Phe Tyr Ser Phe Phe Lys Ser Leu Val Gly Lys Asp Val Val 
1               5                   10                  15      


Val Glu Leu Lys Asn Asp Leu Ser Ile Cys Gly Thr Leu His Ser Val 
            20                  25                  30          


Asp Gln Tyr Leu Asn Ile Lys Leu Thr Asp Ile Ser Val Thr Asp Pro 
        35                  40                  45              


Glu Lys Tyr Pro His Met Leu Ser Val Lys Asn Cys Phe Ile Arg Gly 
    50                  55                  60                  


Ser Val Val Arg Tyr Val Gln Leu Pro Ala Asp Glu Val Asp Thr Gln 
65                  70                  75                  80  


Leu Leu Gln Asp Ala Ala Arg Lys Glu Ala Leu Gln Gln Lys Gln 
                85                  90                  95  


<210>  1602
<211>  2509
<212>  DNA
<213>  Homosapiens

<400>  1602
gtctcaaatt tgcagggagg gacggggtgg ggggtggggg gaccccggtt gtgcagtttg     60

atattgaggg agcccccacc tactcgctgg ggctgcgtaa tctggacgtt tccaaactga    120

agcgaaggcg tcgggagact aggcctcaga gaaccatggc tactgccaag ggaatcgcca    180

taggcatcga cctgggcacc acctactcct gtgtgggggt gttccagcac ggcaaggtgg    240

agatcatcgc caacgaccag ggcaaccgca ccacccccag ctacgtggcc ttcacagaca    300

ccgagcggct cattggggat gcggccaaga accaggtagc aatgaatccc cagaacactg    360

tttttgatgc taaacgtctg atcggcagga aatttaatga tcctgttgta caagcagata    420

tgaaactttg gccttttcaa gtgattaatg aaggaggcaa gcccaaagtc cttgtgtcct    480

acaaagggga gaataaagct ttctaccctg aggaaatctc ttcgatggta ttgactaagt    540

tgaaggagac tgctgaggcc tttttgggcc accctgtcac caatgcagtg attaccgtgc    600

cagcctattt caatgactct caacgtcagg ctactaagga tgcaggtgtg attgctggac    660

ttaatgtgct aagaatcatc aatgagccca cggctgctgc cattgcctat ggtttagata    720

aaggaggtca aggagaacga catgtcctga tttttgatct gggtggaggc acatttgatg    780

tgtcaattct gaccatagat gatgggattt ttgaggtaaa ggccactgct ggggacactc    840

acctgggtgg ggaggacttt gacaacaggc ttgtgagcca cttcgtggag gagttcaaga    900

ggaaacacaa aaaggacatc agccagaaca agcgagccgt gaggcggctg cgcaccgcct    960

gcgagagggc caagaggacc ctgtcgtcca gcacccaggc caacctagaa attgattcac   1020

tttatgaagg cattgacttc tatacatcca tcaccagagc tcgatttgaa gagttgtgtg   1080

cagacctgtt taggggtacc ctggagcctg tagaaaaagc gcttcgggat gccaagatgg   1140

ataaggctaa aatccatgac attgttttag tagggggctc cacccgcatc cccaaggtgc   1200

agcggctgct tcaggactac ttcaatggac gtgatctcaa caagagcatc aaccctgatg   1260

aggccgtagc atatggggct gcggtacaag cagccatcct gatgggggac aagtctgaga   1320

aggtacagga cctgctgctg ctggacgtgg ctcccctgtc cctggggctg gagacggctg   1380

ggggcgtgat gactgccctg ataaagcgca actccaccat ccccaccaag cagacacaga   1440

ttttcaccac ctactctgac aaccaacccg gggtgctgat ccaggtgtat gagggcgaga   1500

gggccatgac aaaggacaac aacctgctgg ggcggtttga cctgactgga atccctccag   1560

cacccagggg agttcctcag atcgaggtga cgtttgacat tgatgccaat ggtattctca   1620

atgtcacagc catggacaag agcaccggca aggtgaacaa gatcaccatc accaatgaca   1680

agggccgcct gagcaaggag gagattgagc gcatggttct ggatgctgag aaatataaag   1740

ctgaagatga ggtccagagg gagaaaattg ctgcaaagaa tgccttagaa tcctatgctt   1800

ttaacatgaa gagtgttgtg agtgatgaag gtttgaaggg caagattagt gagtctgata   1860

aaaataaaat attggataaa tgcaacgagc tcctttcgtg gctggaggtc aatcaactgg   1920

cagagaaaga tgagtttgat cataagagaa aggaattgga gcagatgtgt aaccctatca   1980

tcacaaaact ctaccaagga ggatgcactg ggcctgcctg cggaacaggg tatgtgcctg   2040

gaaggcctgc cacaggcccc acaattgaag aagtagatta attcttttta gaactgaagc   2100

atcctaggat gcctctacat gtatttcatt cccctcatct tcaaacatca ttattattct   2160

tgaccagacc tgaatctaag ttaccatccc ttggaaattc tggagaagga gtctcatgca   2220

ccacctatca cactccctca catcctgttt ctgactttgg aatggactca ggaaaactag   2280

gcccctcttt aaaccgtgtg atgtatttga atgtctgtta tttccagcca ccctaacatt   2340

cttcttcctg tgtggatgct tatttgtcaa tcagtaaatt tgttcgtaaa gaaaattact   2400

tctggtattt aggctgtgaa tgtaccttga aggggagagt tcatggagag agcatgtgtt   2460

ctctgattgt gaggtcactg tgaatgatta aattggtaag ggtaaagta               2509


<210>  1603
<211>  641
<212>  PRT
<213>  Homosapiens

<400>  1603

Met Ala Thr Ala Lys Gly Ile Ala Ile Gly Ile Asp Leu Gly Thr Thr 
1               5                   10                  15      


Tyr Ser Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala 
            20                  25                  30          


Asn Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp 
        35                  40                  45              


Thr Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn 
    50                  55                  60                  


Pro Gln Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe 
65                  70                  75                  80  


Asn Asp Pro Val Val Gln Ala Asp Met Lys Leu Trp Pro Phe Gln Val 
                85                  90                  95      


Ile Asn Glu Gly Gly Lys Pro Lys Val Leu Val Ser Tyr Lys Gly Glu 
            100                 105                 110         


Asn Lys Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys 
        115                 120                 125             


Leu Lys Glu Thr Ala Glu Ala Phe Leu Gly His Pro Val Thr Asn Ala 
    130                 135                 140                 


Val Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr 
145                 150                 155                 160 


Lys Asp Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn 
                165                 170                 175     


Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Gly Gly Gln 
            180                 185                 190         


Gly Glu Arg His Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp 
        195                 200                 205             


Val Ser Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr 
    210                 215                 220                 


Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val 
225                 230                 235                 240 


Ser His Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser 
                245                 250                 255     


Gln Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala 
            260                 265                 270         


Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Asn Leu Glu Ile Asp Ser 
        275                 280                 285             


Leu Tyr Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe 
    290                 295                 300                 


Glu Glu Leu Cys Ala Asp Leu Phe Arg Gly Thr Leu Glu Pro Val Glu 
305                 310                 315                 320 


Lys Ala Leu Arg Asp Ala Lys Met Asp Lys Ala Lys Ile His Asp Ile 
                325                 330                 335     


Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Arg Leu Leu 
            340                 345                 350         


Gln Asp Tyr Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp 
        355                 360                 365             


Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly 
    370                 375                 380                 


Asp Lys Ser Glu Lys Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro 
385                 390                 395                 400 


Leu Ser Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile 
                405                 410                 415     


Lys Arg Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr 
            420                 425                 430         


Tyr Ser Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu 
        435                 440                 445             


Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Asp Leu Thr 
    450                 455                 460                 


Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe 
465                 470                 475                 480 


Asp Ile Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Met Asp Lys Ser 
                485                 490                 495     


Thr Gly Lys Val Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu 
            500                 505                 510         


Ser Lys Glu Glu Ile Glu Arg Met Val Leu Asp Ala Glu Lys Tyr Lys 
        515                 520                 525             


Ala Glu Asp Glu Val Gln Arg Glu Lys Ile Ala Ala Lys Asn Ala Leu 
    530                 535                 540                 


Glu Ser Tyr Ala Phe Asn Met Lys Ser Val Val Ser Asp Glu Gly Leu 
545                 550                 555                 560 


Lys Gly Lys Ile Ser Glu Ser Asp Lys Asn Lys Ile Leu Asp Lys Cys 
                565                 570                 575     


Asn Glu Leu Leu Ser Trp Leu Glu Val Asn Gln Leu Ala Glu Lys Asp 
            580                 585                 590         


Glu Phe Asp His Lys Arg Lys Glu Leu Glu Gln Met Cys Asn Pro Ile 
        595                 600                 605             


Ile Thr Lys Leu Tyr Gln Gly Gly Cys Thr Gly Pro Ala Cys Gly Thr 
    610                 615                 620                 


Gly Tyr Val Pro Gly Arg Pro Ala Thr Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  1604
<211>  2383
<212>  DNA
<213>  Homosapiens

<400>  1604
gctgctgcga cagtccacta cctttttcga gagtgactcc cgttgtccca aggcttccca     60

gagcgaacct gtgcggctgc aggcaccggc gcgtcgagtt tccggcgtcc ggaaggaccg    120

agctcttctc gcggatccag tgttccgttt ccagccccca atctcagagc cgagccgaca    180

gagagcaggg aaccggcatg gccaaagccg cggcgatcgg catcgacctg ggcaccacct    240

actcctgcgt gggggtgttc caacacggca aggtggagat catcgccaac gaccagggca    300

accgcaccac ccccagctac gtggccttca cggacaccga gcggctcatc ggggatgcgg    360

ccaagaacca ggtggcgctg aacccgcaga acaccgtgtt tgacgcgaag cggctgatcg    420

gccgcaagtt cggcgacccg gtggtgcagt cggacatgaa gcactggcct ttccaggtga    480

tcaacgacgg agacaagccc aaggtgcagg tgagctacaa gggggacacc aaggcattct    540

accccgagga gatctcgtcc atggtgctga ccaagatgaa ggagatcgcc gaggcgtacc    600

tgggctaccc ggtgaccaac gcggtgatca ccgtgccggc ctacttcaac gactcgcagc    660

gccaggccac caaggatgcg ggtgtgatcg cggggctcaa cgtgctgcgg atcatcaacg    720

agcccacggc cgccgccatc gcctacggcc tggacagaac gggcaagggg gagcgcaacg    780

tgctcatctt tgacctgggc gggggcacct tcgacgtgtc catcctgacg atcgacgacg    840

gcatcttcga ggtgaaggcc acggccgggg acacccacct gggtggggag gactttgaca    900

acaggctggt gaaccacttc gtggaggagt tcaagagaaa acacaagaag gacatcagcc    960

agaacaagcg agccgtgagg cggctgcgca ccgcctgcga gagggccaag aggaccctgt   1020

cgtccagcac ccaggccagc ctggagatcg actccctgtt tgagggcatc gacttctaca   1080

cgtccatcac cagggcgagg ttcgaggagc tgtgctccga cctgttccga agcaccctgg   1140

agcccgtgga gaaggctctg cgcgacgcca agctggacaa ggcccagatt cacgacctgg   1200

tcctggtcgg gggctccacc cgcatcccca aggtgcagaa gctgctgcag gacttcttca   1260

acgggcgcga cctgaacaag agcatcaacc ccgacgaggc tgtggcctac ggggcggcgg   1320

tgcaggcggc catcctgatg ggggacaagt ccgagaacgt gcaggacctg ctgctgctgg   1380

acgtggctcc cctgtcgctg gggctggaga cggccggagg cgtgatgact gccctgatca   1440

agcgcaactc caccatcccc accaagcaga cgcagatctt caccacctac tccgacaacc   1500

aacccggggt gctgatccag gtgtacgagg gcgagagggc catgacgaaa gacaacaatc   1560

tgttggggcg cttcgagctg agcggcatcc ctccggcccc caggggcgtg ccccagatcg   1620

aggtgacctt cgacatcgat gccaacggca tcctgaacgt cacggccacg gacaagagca   1680

ccggcaaggc caacaagatc accatcacca acgacaaggg ccgcctgagc aaggaggaga   1740

tcgagcgcat ggtgcaggag gcggagaagt acaaagcgga ggacgaggtg cagcgcgaga   1800

gggtgtcagc caagaacgcc ctggagtcct acgccttcaa catgaagagc gccgtggagg   1860

atgaggggct caagggcaag atcagcgagg ccgacaagaa gaaggtgctg gacaagtgtc   1920

aagaggtcat ctcgtggctg gacgccaaca ccttggccga gaaggacgag tttgagcaca   1980

agaggaagga gctggagcag gtgtgtaacc ccatcatcag cggactgtac cagggtgccg   2040

gtggtcccgg gcctgggggc ttcggggctc agggtcccaa gggagggtct gggtcaggcc   2100

ccaccattga ggaggtagat taggggcctt tccaagattg ctgtttttgt tttggagctt   2160

caagactttg catttcctag tatttctgtt tgtcagttct caatttcctg tgtttgcaat   2220

gttgaaattt tttggtgaag tactgaactt gctttttttc cggtttctac atgcagagat   2280

gaatttatac tgccatctta cgactatttc ttctttttaa tacacttaac tcaggccatt   2340

ttttaagttg gttacttcaa agtaaataaa ctttaaaatt caa                     2383


<210>  1605
<211>  641
<212>  PRT
<213>  Homosapiens

<400>  1605

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Asp Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  1606
<211>  2512
<212>  DNA
<213>  Homosapiens

<400>  1606
gcctgaggag ctgctgcgag ggtccgcttc gtctttcgag agtgactccc gcggtcccaa     60

ggctttccag agcgaacctg tgcggctgca ggcaccggcg tgttgagttt ccggcgttcc    120

gaaggactga gctcttgtcg cggatcccgt ccgccgtttc cagcccccag tctcagagcg    180

gagcccacag agcagggcac cggcatggcc aaagccgcgg cgatcggcat cgacctgggc    240

accacctact cctgcgtggg ggtgttccaa cacggcaagg tggagatcat cgccaacgac    300

cagggcaacc gcaccacccc cagctacgtg gccttcacgg acaccgagcg gctcatcggg    360

gatgcggcca agaaccaggt ggcgctgaac ccgcagaaca ccgtgtttga cgcgaagcgg    420

ctgatcggcc gcaagttcgg cgacccggtg gtgcagtcgg acatgaagca ctggcctttc    480

caggtgatca acgacggaga caagcccaag gtgcaggtga gctacaaggg ggagaccaag    540

gcattctacc ccgaggagat ctcgtccatg gtgctgacca agatgaagga gatcgccgag    600

gcgtacctgg gctacccggt gaccaacgcg gtgatcaccg tgccggccta cttcaacgac    660

tcgcagcgcc aggccaccaa ggatgcgggt gtgatcgcgg ggctcaacgt gctgcggatc    720

atcaacgagc ccacggccgc cgccatcgcc tacggcctgg acagaacggg caagggggag    780

cgcaacgtgc tcatctttga cctgggcggg ggcaccttcg acgtgtccat cctgacgatc    840

gacgacggca tcttcgaggt gaaggccacg gccggggaca cccacctggg tggggaggac    900

tttgacaaca ggctggtgaa ccacttcgtg gaggagttca agagaaaaca caagaaggac    960

atcagccaga acaagcgagc cgtgaggcgg ctgcgcaccg cctgcgagag ggccaagagg   1020

accctgtcgt ccagcaccca ggccagcctg gagatcgact ccctgtttga gggcatcgac   1080

ttctacacgt ccatcaccag ggcgaggttc gaggagctgt gctccgacct gttccgaagc   1140

accctggagc ccgtggagaa ggctctgcgc gacgccaagc tggacaaggc ccagattcac   1200

gacctggtcc tggtcggggg ctccacccgc atccccaagg tgcagaagct gctgcaggac   1260

ttcttcaacg ggcgcgacct gaacaagagc atcaaccccg acgaggctgt ggcctacggg   1320

gcggcggtgc aggcggccat cctgatgggg gacaagtccg agaacgtgca ggacctgctg   1380

ctgctggacg tggctcccct gtcgctgggg ctggagacgg ccggaggcgt gatgactgcc   1440

ctgatcaagc gcaactccac catccccacc aagcagacgc agatcttcac cacctactcc   1500

gacaaccaac ccggggtgct gatccaggtg tacgagggcg agagggccat gacgaaagac   1560

aacaatctgt tggggcgctt cgagctgagc ggcatccctc cggcccccag gggcgtgccc   1620

cagatcgagg tgaccttcga catcgatgcc aacggcatcc tgaacgtcac ggccacggac   1680

aagagcaccg gcaaggccag caagatcacc atcaccaacg acaagggccg cctgagcaag   1740

gaggagatcg agcgcatggt gcaggaggcg gagaagtaca aagcggagga cgaggtgcag   1800

cgcgagaggg tgtcagccaa gaacgccctg gagtcctacg ccttcaacat gaagagcgcc   1860

gtggaggatg aggggctcaa gggcaagatc agcgaggcgg acaagaagaa ggttctggac   1920

aagtgtcaag aggtcatctc gtggctggac gccaacacct tggccgagaa ggacgagttt   1980

gagcacaaga ggaaggagct ggagcaggtg tgtaacccca tcatcagcgg actgtaccag   2040

ggtgccggtg gtcccgggcc tgggggcttc ggggctcagg gtcccaaggg agggtctggg   2100

tcaggcccta ccattgagga ggtggattag gggcctttgt tctttagtat gtttgtcttt   2160

gaggtggact gttgggactc aaggactttg ctgctgtttt cctatgtcat ttctgcttca   2220

gctctttgct gcttcacttc tttgtaaagt taagttgtaa cctgatggta attagctggc   2280

ttcattattt ttgtagtaca accgatatgt tcattagaat tctttgcatt taatgttgat   2340

actgtaaggg tgtttcgttc cctttaaatg aatcaacact gccaccttct gtacgagttt   2400

gttttttttt tttttttttt ttttttttgc ttggcgaaaa cactacaaag gctgggaatg   2460

tatgttttta taatttgttt atttaaatat gaaaaataaa atgttaaact tt           2512


<210>  1607
<211>  641
<212>  PRT
<213>  Homosapiens

<400>  1607

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Ser Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  1608
<211>  842
<212>  DNA
<213>  Homosapiens

<400>  1608
ctttttgcga agtgggctcg tgggttggca gtatgagagt tgtaatggcc cgactgttga     60

gtgaggggga gcaggggatc ccaacggctt gcgctgcctt tgcgcagcag ccggcgggcg    120

gccacgtcgc ggcctggctg gggtaggaga gggcggtccc cagtgcagtt gggtgaacta    180

ccgttgcaca ctggagtttc tggtgtcttt gcttggaact gacctagctc gtggcagggg    240

gaactcggct agcggcccca cagcccctgc tgactcaaaa caactgagtt gtaagacgtt    300

catcgccgtg ttatccttga gtaaagaagc gggcttttgc catgttgtcc aggctggtct    360

ctactcctgg gctcaagcag tcctcctgcc tcagtctccc aaagtgctgg aattacaggg    420

aatgaactct ggaagcccag ccagggacaa tgcaccttca cagagattct gcactaatct    480

gagtgaaggt ctaaggtttg gaatctcccc ctcatggaga gaagctttgt atggctgtca    540

tgcttagaca gtgattcctg caacttgacc ttcaggctgg gagaggtgga gagccatgcc    600

tgttctcctt ccttgctatg gaatttgctg acacaatatc ttccgcctgg tgctgggcat    660

atcctaagaa cttacaactt tcctgtatta tcctgtgtga gcagctgtca ccttattggg    720

ggaaaaatgc ctgaaaatta gggggcactt caagtagata gcttctattt cctatatttg    780

tcttatatac aagtatttgc ttttatcaaa ataattccaa taaagcattt taaagtaaag    840

aa                                                                   842


<210>  1609
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  1609

Met Glu Arg Ser Phe Val Trp Leu Ser Cys Leu Asp Ser Asp Ser Cys 
1               5                   10                  15      


Asn Leu Thr Phe Arg Leu Gly Glu Val Glu Ser His Ala Cys Ser Pro 
            20                  25                  30          


Ser Leu Leu Trp Asn Leu Leu Thr Gln Tyr Leu Pro Pro Gly Ala Gly 
        35                  40                  45              


His Ile Leu Arg Thr Tyr Asn Phe Pro Val Leu Ser Cys Val Ser Ser 
    50                  55                  60                  


Cys His Leu Ile Gly Gly Lys Met Pro Glu Asn 
65                  70                  75  


<210>  1610
<211>  748
<212>  DNA
<213>  Homosapiens

<400>  1610
ctttttgcga agtgggctcg tgggttggca gtatgagagt tgtaatggcc cgactgttga     60

gtgaggggga gcaggggatc ccaacggctt gcgctgcctt tgcgcagcag ccggcgggcg    120

gccacgtcgc ggcctggctg gggtaggaga gggcggtccc cagtgcagtt gggtgaacta    180

ccgttgcaca ctggagtttc tggtgtcttt gcttggaact gacctagctc gtggcagggg    240

gaactcggct agcggcccca cagcccctgc tgactcaaaa caactgagtt gtaagacgtt    300

catcgccgtg ttatccttga gtaaagaatg aactctggaa gcccagccag ggacaatgca    360

ccttcacaga gattctgcac taatctgagt gaaggtctaa ggtttggaat ctccccctca    420

tggagagaag ctttgtatgg ctgtcatgct tagacagtga ttcctgcaac ttgaccttca    480

ggctgggaga ggtggagagc catgcctgtt ctccttcctt gctatggaat ttgctgacac    540

aatatcttcc gcctggtgct gggcatatcc taagaactta caactttcct gtattatcct    600

gtgtgagcag ctgtcacctt attgggggaa aaatgcctga aaattagggg gcacttcaag    660

tagatagctt ctatttccta tatttgtctt atatacaagt atttgctttt atcaaaataa    720

ttccaataaa gcattttaaa gtaaagaa                                       748


<210>  1611
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  1611

Met Glu Arg Ser Phe Val Trp Leu Ser Cys Leu Asp Ser Asp Ser Cys 
1               5                   10                  15      


Asn Leu Thr Phe Arg Leu Gly Glu Val Glu Ser His Ala Cys Ser Pro 
            20                  25                  30          


Ser Leu Leu Trp Asn Leu Leu Thr Gln Tyr Leu Pro Pro Gly Ala Gly 
        35                  40                  45              


His Ile Leu Arg Thr Tyr Asn Phe Pro Val Leu Ser Cys Val Ser Ser 
    50                  55                  60                  


Cys His Leu Ile Gly Gly Lys Met Pro Glu Asn 
65                  70                  75  


<210>  1612
<211>  1943
<212>  DNA
<213>  Homosapiens

<400>  1612
cgggaagcgc ggcggggcct ccagaccggg gcgggcttaa gggtgacatc tgcgctttaa     60

agggtccggg tcagctgact cccgactctg tggagtctag ctgccagggt cgcggcagct    120

gcggggagag atgactgggg agcgacccag cacggcgctc ccggacagac gctgggggcc    180

gcggattctg ggcttctggg gaggctgtag ggtttgggtg tttgccgcga tcttcctgct    240

gctgtctctg gcagcctcct ggtccaaggc tgagaacgac ttcggtctgg tgcagccgct    300

ggtgaccatg gagcaactgc tgtgggtgag cgggagacag atcggctcag tggacacctt    360

ccgcatcccg ctcatcacag ccactccgcg gggcactctt ctcgcctttg ctgaggcgag    420

gaaaatgtcc tcatccgatg agggggccaa gttcatcgcc ctgcggaggt ccatggacca    480

gggcagcaca tggtctccta cagcgttcat tgtcaatgat ggggatgtcc ccgatgggct    540

gaaccttggg gcagtagtga gcgatgttga gacaggagta gtatttcttt tctactccct    600

ttgtgctcac aaggccggct gccaggtggc ctctaccatg ttggtatgga gcaaggatga    660

tggtgtttcc tggagcacac cccggaatct ctccctggat attggcactg aagtgtttgc    720

ccctggaccg ggctctggta ttcagaaaca gcgggagcca cggaagggcc gcctcatcgt    780

gtgtggccat gggacgctgg agcgggacgg agtcttctgt ctcctcagcg atgatcatgg    840

tgcctcctgg cgctacggaa gtggggtcag cggcatcccc tacggtcagc ccaagcagga    900

aaatgatttc aatcctgatg aatgccagcc ctatgagctc ccagatggct cagtcgtcat    960

caatgcccga aaccagaaca actaccactg ccactgccga attgtcctcc gcagctatga   1020

tgcctgtgat acactaaggc cccgtgatgt gaccttcgac cctgagctcg tggaccctgt   1080

ggtagctgca ggagctgtag tcaccagctc cggcattgtc ttcttctcca acccagcaca   1140

tccagagttc cgagtgaacc tgaccctgcg atggagcttc agcaatggta cctcatggcg   1200

gaaagagaca gtccagctat ggccaggccc cagtggctat tcatccctgg caaccctgga   1260

gggcagcatg gatggagagg agcaggcccc ccagctctac gtcctgtatg agaaaggccg   1320

gaaccactac acagagagca tctccgtggc caaaatcagt gtctatggga cactctgagc   1380

tgtgccactg ccacaggggt attctgcctt caggactctg ccttcaggaa cacgggtctg   1440

tagagggtct gctggagacg cctgaaagac agttccatct tcctttagac tccagccttg   1500

gcaaaatcac cttcccttta ccagggaaat cacttccttt aggactgaaa gctaggcgtc   1560

ctctcccaca aaaaagtcct gccctcatct gagaatactg tctttccata tggctaagtg   1620

tggccccacc accctctctg ccctcccggg acattgattg gtcctgtctt gggcaggtct   1680

agtgagctgt agaattgaat caatgtgaac tcagggaact ggggaaggct gagcctcctc   1740

tttggtgttg cggtaagata accgacaggg ctggtgaaag tccccagatg gcaggatatt   1800

tggtttcaga gtaaggacta ggtgcaccac catgactgac tatcaatcaa aatgtttgta   1860

acttaaaatt tttaatgaag gataatgaat atttgtagag tctctatggt tctgtcaatg   1920

caaaaaaaaa aaaaaaaaaa aaa                                           1943


<210>  1613
<211>  415
<212>  PRT
<213>  Homosapiens

<400>  1613

Met Thr Gly Glu Arg Pro Ser Thr Ala Leu Pro Asp Arg Arg Trp Gly 
1               5                   10                  15      


Pro Arg Ile Leu Gly Phe Trp Gly Gly Cys Arg Val Trp Val Phe Ala 
            20                  25                  30          


Ala Ile Phe Leu Leu Leu Ser Leu Ala Ala Ser Trp Ser Lys Ala Glu 
        35                  40                  45              


Asn Asp Phe Gly Leu Val Gln Pro Leu Val Thr Met Glu Gln Leu Leu 
    50                  55                  60                  


Trp Val Ser Gly Arg Gln Ile Gly Ser Val Asp Thr Phe Arg Ile Pro 
65                  70                  75                  80  


Leu Ile Thr Ala Thr Pro Arg Gly Thr Leu Leu Ala Phe Ala Glu Ala 
                85                  90                  95      


Arg Lys Met Ser Ser Ser Asp Glu Gly Ala Lys Phe Ile Ala Leu Arg 
            100                 105                 110         


Arg Ser Met Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile Val 
        115                 120                 125             


Asn Asp Gly Asp Val Pro Asp Gly Leu Asn Leu Gly Ala Val Val Ser 
    130                 135                 140                 


Asp Val Glu Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys Ala His 
145                 150                 155                 160 


Lys Ala Gly Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys Asp 
                165                 170                 175     


Asp Gly Val Ser Trp Ser Thr Pro Arg Asn Leu Ser Leu Asp Ile Gly 
            180                 185                 190         


Thr Glu Val Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Gln Arg 
        195                 200                 205             


Glu Pro Arg Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu Glu 
    210                 215                 220                 


Arg Asp Gly Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala Ser Trp 
225                 230                 235                 240 


Arg Tyr Gly Ser Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro Lys Gln 
                245                 250                 255     


Glu Asn Asp Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro Asp 
            260                 265                 270         


Gly Ser Val Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys His 
        275                 280                 285             


Cys Arg Ile Val Leu Arg Ser Tyr Asp Ala Cys Asp Thr Leu Arg Pro 
    290                 295                 300                 


Arg Asp Val Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val Ala Ala 
305                 310                 315                 320 


Gly Ala Val Val Thr Ser Ser Gly Ile Val Phe Phe Ser Asn Pro Ala 
                325                 330                 335     


His Pro Glu Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser Asn 
            340                 345                 350         


Gly Thr Ser Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro Ser 
        355                 360                 365             


Gly Tyr Ser Ser Leu Ala Thr Leu Glu Gly Ser Met Asp Gly Glu Glu 
    370                 375                 380                 


Gln Ala Pro Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn His Tyr 
385                 390                 395                 400 


Thr Glu Ser Ile Ser Val Ala Lys Ile Ser Val Tyr Gly Thr Leu 
                405                 410                 415 


<210>  1614
<211>  2347
<212>  DNA
<213>  Homosapiens

<400>  1614
atggggggaa agcagcggga cgaggatgac gaggcctacg ggaagccagt caaatacgac     60

ccctcctttc gaggccccat caagaacaga agctgcacag atgtcatctg ctgcgtcctc    120

ttcctgctct tcattctagg ttacatcgtg gtggggattg tggcctggtt gtatggagac    180

ccccggcaag tcctctaccc caggaactct actggggcct actgtggcat gggggagaac    240

aaagataagc cgtatctcct gtacttcaac atcttcagct gcatcctgtc cagcaacatc    300

atctcagttg ctgagaacgg cctacagtgc cccacacccc aggtgtgtgt gtcctcctgc    360

ccggaggacc catggactgt gggaaaaaac gagttctcac agactgttgg ggaagtcttc    420

tatacaaaaa acaggaactt ttgtctgcca ggggtaccct ggaatatgac ggtgatcaca    480

agcctgcaac aggaactctg ccccagtttc ctcctcccct ctgctccagc tctgggacgc    540

tgctttccat ggaccaacat tactccaccg gcgctcccag ggatcaccaa tgacaccacc    600

atacagcagg ggatcagcgg tcttattgac agcctcaatg cccgagacat cagtgttaag    660

atctttgaag attttgccca gtcctggtat tggattcttg ttgccctggg ggtggctctg    720

gtcttgagcc tactgtttat cttgcttctg cgcctggtgg ctgggcccct ggtgctggtg    780

ctgatcctgg gagtgctggg cgtgctggca tatggcatct actactgctg ggaggagtac    840

cgagtgctgc gggacaaggg cgcctccatc tcccagctgg gtttcaccac caacctcagt    900

gcctaccaga gcgtgcagga gacctggctg gccgccctga tcgtgttggc ggtgcttgaa    960

gccatcctgc tgctggtgct catcttcctg cggcagcgga ttcgtattgc catcgccctc   1020

ctgaaggagg ccagcaaggc tgtgggacag atgatgtcta ccatgttcta cccactggtc   1080

acctttgtcc tcctcctcat ctgcattgcc tactgggcca tgactgctct gtatcctctg   1140

cccacgcagc cagccactct tggatatgtg ctctgggcat ccaacatcag ctcccccggc   1200

tgtgagaaag tgccaataaa tacatcatgc aaccccacgg cccaccttgt gaactcctcg   1260

tgcccagggc tgatgtgcgt cttccagggc tactcatcca aaggcctaat ccaacgttct   1320

gtcttcaatc tgcaaatcta tggggtcctg gggctcttct ggacccttaa ctgggtactg   1380

gccctgggcc aatgcgtcct cgctggagcc tttgcctcct tctactgggc cttccacaag   1440

ccccaggaca tccctacctt ccccttaatc tctgccttca tccgcacact ccgttaccac   1500

actgggtcat tggcatttgg agccctcatc ctgacccttg tgcagatagc ccgggtcatc   1560

ttggagtata ttgaccacaa gctcagagga gtgcagaacc ctgtagcccg ctgcatcatg   1620

tgctgtttca agtgctgcct ctggtgtctg gaaaaattta tcaagttcct aaaccgcaat   1680

gcatacatca tgatcgccat ctacgggaag aatttctgtg tctcagccaa aaatgcgttc   1740

atgctactca tgcgaaacat tgtcagggtg gtcgtcctgg acaaagtcac agacctgctg   1800

ctgttctttg ggaagctgct ggtggtcgga ggcgtggggg tcctgtcctt cttttttttc   1860

tccggtcgca tcccggggct gggtaaagac tttaagagcc cccacctcaa ctattactgg   1920

ctgcccatca tgacctccat cctgggggcc tatgtcatcg ccagcggctt cttcagcgtt   1980

ttcggcatgt gtgtggacac gctcttcctc tgcttcctgg aagacctgga gcggaacaac   2040

ggctccctgg accggcccta ctacatgtcc aagagccttc taaagattct gggcaagaag   2100

aacgaggcgc ccccggacaa caagaagagg aagaagtgac agctccggcc ctgatccagg   2160

actgcacccc acccccaccg tccagccatc caacctcact tcgccttaca ggtctccatt   2220

ttgtggtaaa aaaaggtttt aggccaggcg ccgtggctca cgcctgtaat ccaacacttt   2280

gagaggctga ggcgggcgga tcacctgagt caggagttcg agaccagcct ggccaacatg   2340

gtgaaac                                                             2347


<210>  1615
<211>  712
<212>  PRT
<213>  Homosapiens

<400>  1615

Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro 
1               5                   10                  15      


Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys 
            20                  25                  30          


Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr 
        35                  40                  45              


Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val 
    50                  55                  60                  


Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn 
65                  70                  75                  80  


Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu 
                85                  90                  95      


Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr 
            100                 105                 110         


Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly 
        115                 120                 125             


Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn 
    130                 135                 140                 


Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr 
145                 150                 155                 160 


Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro 
                165                 170                 175     


Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Ile Thr Pro Pro Ala Leu 
            180                 185                 190         


Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu 
        195                 200                 205             


Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp 
    210                 215                 220                 


Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu 
225                 230                 235                 240 


Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro 
                245                 250                 255     


Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly 
            260                 265                 270         


Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala 
        275                 280                 285             


Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser 
    290                 295                 300                 


Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu 
305                 310                 315                 320 


Ala Ile Leu Leu Leu Val Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile 
                325                 330                 335     


Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met 
            340                 345                 350         


Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys 
        355                 360                 365             


Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Pro Leu Pro Thr Gln Pro 
    370                 375                 380                 


Ala Thr Leu Gly Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly 
385                 390                 395                 400 


Cys Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu 
                405                 410                 415     


Val Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser 
            420                 425                 430         


Ser Lys Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly 
        435                 440                 445             


Val Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln 
    450                 455                 460                 


Cys Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys 
465                 470                 475                 480 


Pro Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr 
                485                 490                 495     


Leu Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr 
            500                 505                 510         


Leu Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu 
        515                 520                 525             


Arg Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys 
    530                 535                 540                 


Cys Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn 
545                 550                 555                 560 


Ala Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala 
                565                 570                 575     


Lys Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val 
            580                 585                 590         


Leu Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val 
        595                 600                 605             


Val Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile 
    610                 615                 620                 


Pro Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp 
625                 630                 635                 640 


Leu Pro Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly 
                645                 650                 655     


Phe Phe Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe 
            660                 665                 670         


Leu Glu Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr 
        675                 680                 685             


Met Ser Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro 
    690                 695                 700                 


Pro Asp Asn Lys Lys Arg Lys Lys 
705                 710         


<210>  1616
<211>  2579
<212>  DNA
<213>  Homosapiens

<400>  1616
actccggaga ctgagccatg gggggaaagc agcgggacga ggatgacgag gcctacggga     60

agccagtcaa atacgacccc tcctttcgag gccccatcaa gaacagaagc tgcacagatg    120

tcatctgctg cgtcctcttc ctgctcttca ttctaggtta catcgtggtg gggattgtgg    180

cctggttgta tggagacccc cggcaagtcc tctaccccag gaactctact ggggcctact    240

gtggcatggg ggagaacaaa gataagccgt atctcctgta cttcaacatc ttcagctgca    300

tcctgtccag caacatcatc tcagttgctg agaacggcct acagtgcccc acaccccagg    360

tgtgtgtgtc ctcctgcccg gaggacccat ggactgtggg aaaaaacgag ttctcacaga    420

ctgttgggga agtcttctat acaaaaagca gcaacttttg tctgccaggg gtaccctgga    480

atatgacggt gatcacaagc ctgcaacagg aactctgccc cagtttcctc ctcccctctg    540

ctccagctct gggacgctgc tttccatgga ccaacattac tccaccggcg ctcccaggga    600

tcaccaatga caccaccata cagcagggga tcagcggtct tattgacagc ctcaatgccc    660

gagacatcag tgttaagatc tttgaagatt ttgcccagtc ctggtattgg attcttgttg    720

ccctgggggt ggctctggtc ttgagcctac tgtttatctt gcttctgcgc ctggtggctg    780

ggcccctggt gctggtgctg atcctgggag tgctgggcgt gctggcatac ggcatctact    840

actgctggga ggagtaccga gtgctgcggg acaagggcgc ctccatctcc cagctgggtt    900

tcaccaccaa cctcagtgcc taccagagcg tgcaggagac ctggctggcc gccctgatcg    960

tgttggcggt gcttgaagcc atcctgctgc tggtgctcat cttcctgcgg cagcggattc   1020

gtattgccat cgccctcctg aaggaggcca gcaaggctgt gggacagatg atgtctacca   1080

tgttctaccc actggtcacc tttgtcctcc tcctcatctg cattgcctac tgggccatga   1140

ctgctctgta cctggctaca tcggggcaac cccagtatgt gctctgggca tccaacatca   1200

gctcccccgg ctgtgagaaa gtgccaataa atacatcatg caaccccacg gcccaccttg   1260

tgaactcctc gtgcccaggg ctgatgtgcg tcttccaggg ctactcatcc aaaggcctaa   1320

tccaacgttc tgtcttcaat ctgcaaatct atggggtcct ggggctcttc tggaccctta   1380

actgggtact ggccctgggc caatgcgtcc tcgctggagc ctttgcctcc ttctactggg   1440

ccttccacaa gccccaggac atccctacct tccccttaat ctctgccttc atccgcacac   1500

tccgttacca cactgggtca ttggcatttg gagccctcat cctgaccctt gtgcagatag   1560

cccgggtcat cttggagtat attgaccaca agctcagagg agtgcagaac cctgtagccc   1620

gctgcatcat gtgctgtttc aagtgctgcc tctggtgtct ggaaaaattt atcaagttcc   1680

taaaccgcaa tgcatacatc atgatcgcca tctacgggaa gaatttctgt gtctcagcca   1740

aaaatgcgtt catgctactc atgcgaaaca ttgtcagggt ggtcgtcctg gacaaagtca   1800

cagacctgct gctgttcttt gggaagctgc tggtggtcgg aggcgtgggg gtcctgtcct   1860

tctttttttt ctccggtcgc atcccggggc tgggtaaaga ctttaagagc ccccacctca   1920

actattactg gctgcccatc atgacctcca tcctgggggc ctatgtcatc gccagcggct   1980

tcttcagcgt tttcggcatg tgtgtggaca cgctcttcct ctgcttcctg gaagacctgg   2040

agcggaacaa cggctccctg gaccggccct actacatgtc caagagcctt ctaaagattc   2100

tgggcaagaa gaacgaggcg cccccggaca acaagaagag gaagaagtga cagctccggc   2160

cctgatccag gactgcaccc cacccccacc gtccagccat ccaacctcac ttcgccttac   2220

aggtctccat tttgtggtaa aaaagggttt taggccaggc gccgtggctc acgcctgtaa   2280

tccaacactt tgagaggctg aggcgggcgg atcacctgag tcaggagttc gagaccagcc   2340

tggccaacat ggtgaaacct ccgtctctat taaaaataca aaaattagcc gagagtggtg   2400

gcatgcacct gtcatcccag ctactcggga ggctgaggca ggagaatcgc ttgaacccgg   2460

gaggcagagg ttgcagtgag ccgagatcgc gccactgcac tccaacctgg gtgacagact   2520

ctgtctccaa aacaaaacaa acaaacaaaa agattttatt aaagatattt tgttaactc    2579


<210>  1617
<211>  710
<212>  PRT
<213>  Homosapiens

<400>  1617

Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro 
1               5                   10                  15      


Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys 
            20                  25                  30          


Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr 
        35                  40                  45              


Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val 
    50                  55                  60                  


Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn 
65                  70                  75                  80  


Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu 
                85                  90                  95      


Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr 
            100                 105                 110         


Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly 
        115                 120                 125             


Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Ser 
    130                 135                 140                 


Ser Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr 
145                 150                 155                 160 


Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro 
                165                 170                 175     


Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Ile Thr Pro Pro Ala Leu 
            180                 185                 190         


Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu 
        195                 200                 205             


Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp 
    210                 215                 220                 


Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu 
225                 230                 235                 240 


Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro 
                245                 250                 255     


Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly 
            260                 265                 270         


Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala 
        275                 280                 285             


Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser 
    290                 295                 300                 


Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu 
305                 310                 315                 320 


Ala Ile Leu Leu Leu Val Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile 
                325                 330                 335     


Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met 
            340                 345                 350         


Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys 
        355                 360                 365             


Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly Gln 
    370                 375                 380                 


Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys Glu 
385                 390                 395                 400 


Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val Asn 
                405                 410                 415     


Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser Lys 
            420                 425                 430         


Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val Leu 
        435                 440                 445             


Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys Val 
    450                 455                 460                 


Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro Gln 
465                 470                 475                 480 


Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu Arg 
                485                 490                 495     


Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu Val 
            500                 505                 510         


Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg Gly 
        515                 520                 525             


Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys Cys 
    530                 535                 540                 


Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr 
545                 550                 555                 560 


Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys Asn 
                565                 570                 575     


Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu Asp 
            580                 585                 590         


Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val Gly 
        595                 600                 605             


Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro Gly 
    610                 615                 620                 


Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu Pro 
625                 630                 635                 640 


Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe 
                645                 650                 655     


Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu 
            660                 665                 670         


Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser 
        675                 680                 685             


Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp 
    690                 695                 700                 


Asn Lys Lys Arg Lys Lys 
705                 710 


<210>  1618
<211>  3994
<212>  DNA
<213>  Homosapiens

<400>  1618
gcaagcggcg atggcggcgg cggcgggagc tgcagcggcg gcggccgccg agggggaggc     60

ccccgctgag atgggggcgc tgctgctgga gaaggaaacc agaggagcca ccgagagagt    120

tcatggctct ttgggggaca cccctcgtag tgaagaaacc ctgcccaagg ccaaccccga    180

ctccctggag cctgctggcc cctcatctcc agcctctgtc actgtcactg ttggtgatga    240

gggggctgac acccctgtag gggctacacc actcattggg gatgaatctg agaatcttga    300

gggagatggg gacctccgtg ggggccggat cctgctgggc catgccacaa agtcattccc    360

ctcttccccc agcaaggggg gttcctgtcc tagccgggcc aagatgtcaa tgacaggggc    420

gggaaaatca cctccatctg tccagagttt ggctatgagg ctactgagta tgccaggagc    480

ccagggagct gcagcagcag ggtctgaacc ccctccagcc accacgagcc cagagggaca    540

gcccaaggtc caccgagccc gcaaaaccat gtccaaacca ggaaatggac agcccccggt    600

ccctgagaag cggccccctg aaatacagca tttccgcatg agtgatgatg tccactcact    660

gggaaaggtg acctcagatc tggccaaaag gaggaagctg aactcaggag gtggcctgtc    720

ggaggagtta ggttctgccc ggcgttcagg agaagtgacc ctgacgaaag gggaccccgg    780

gtccctggag gagtgggaga cggtggtggg tgatgacttc agtctctact atgattccta    840

ctctgtggat gagcgcgtgg actccgacag caagtctgaa gttgaagctc taactgaaca    900

actaagtgaa gaggaggagg aggaagagga ggaagaagaa gaagaggaag aggaggagga    960

agaggaagaa gaagaggaag atgaggagtc agggaatcag tcagatagga gtggttccag   1020

tggccggcgc aaggccaaga agaaatggcg aaaagacagc ccatgggtga agccgtctcg   1080

gaaacggcgc aagcgggagc ctccgcgggc caaggagcca cgaggagtga atggtgtggg   1140

ctcctcaggc cccagtgagt acatggaggt ccctctgggg tccctggagc tgcccagcga   1200

ggggaccctc tcccccaacc acgctggggt gtccaatgac acatcttcgc tggagacaga   1260

gcgagggttt gaggagttgc ccctgtgcag ctgccgcatg gaggcaccca agattgaccg   1320

catcagcgag agggcggggc acaagtgcat ggccactgag agtgtggacg gagagctgtc   1380

aggctgcaat gccgccatcc tcaagcggga gaccatgagg ccatccagcc gtgtggccct   1440

gatggtgctc tgtgagaccc accgcgcccg catggtcaaa caccactgct gcccgggctg   1500

cggctacttc tgcacggcgg gcaccttcct ggagtgccac cctgacttcc gtgtggccca   1560

ccgcttccac aaggcctgtg tgtctcagct gaatgggatg gtcttctgtc cccactgtgg   1620

ggaggatgct tctgaagctc aagaggtgac catcccccgg ggtgacgggg tgaccccacc   1680

ggccggcact gcagctcctg cacccccacc cctgtcccag gatgtccccg ggagagcaga   1740

cacttctcag cccagtgccc ggatgcgagg gcatggggaa ccccggcgcc cgccctgcga   1800

tcccctggct gacaccattg acagctcagg gccctccctg accctgccca atgggggctg   1860

cctttcagcc gtggggctgc cactggggcc aggccgggag gccctggaaa aggccctggt   1920

catccaggag tcagagaggc ggaagaagct ccgtttccac cctcggcagt tgtacctgtc   1980

cgtgaagcag ggcgagctgc agaaggtgat cctgatgctg ttggacaacc tggaccccaa   2040

cttccagagc gaccagcaga gcaagcgcac gcccctgcat gcagccgccc agaagggctc   2100

cgtggagatc tgccatgtgc tgctgcaggc tggagccaac ataaatgcag tggacaaaca   2160

gcagcggacg ccactgatgg aggccgtggt gaacaaccac ctggaggtag cccgttacat   2220

ggtgcagcgt ggtggctgtg tctatagcaa ggaggaggac ggttccacct gcctccacca   2280

cgcagccaaa atcgggaact tggagatggt cagcctgctg ctgagcacag gacaggtgga   2340

cgtcaacgcc caggacagtg gggggtggac gcccatcatc tgggctgcag agcacaagca   2400

catcgaggtg atccgcatgc tactgacgcg gggcgccgac gtcaccctca ctgacaacga   2460

ggagaacatc tgcctgcact gggcctcctt cacgggcagc gccgccatcg ccgaagtcct   2520

tctgaatgcg cgctgtgacc tccatgctgt caactaccat ggggacaccc ccctgcacat   2580

cgcagctcgg gagagctacc atgactgcgt gctgttattc ctgtcacgtg gggccaaccc   2640

tgagctgcgg aacaaagagg gggacacagc atgggacctg actcccgagc gctccgacgt   2700

gtggtttgcg cttcaactca accgcaagct ccgacttggg gtgggaaatc gggccatccg   2760

cacagagaag atcatctgcc gggacgtggc tcggggctat gagaacgtgc ccattccctg   2820

tgtcaacggt gtggatgggg agccctgccc tgaggattac aagtacatct cagagaactg   2880

cgagacgtcc accatgaaca tcgatcgcaa catcacccac ctgcagcact gcacgtgtgt   2940

ggacgactgc tctagctcca actgcctgtg cggccagctc agcatccggt gctggtatga   3000

caaggatggg cgattgctcc aggaatttaa caagattgag cctccgctga ttttcgagtg   3060

taaccaggcg tgctcatgct ggagaaactg caagaaccgg gtcgtacaga gtggcatcaa   3120

ggtgcggcta cagctctacc gaacagccaa gatgggctgg ggggtccgcg ccctgcagac   3180

catcccacag gggaccttca tctgcgagta tgtcggggag ctgatctctg atgctgaggc   3240

tgatgtgaga gaggatgatt cttacctctt cgacttagac aacaaggatg gagaggtgta   3300

ctgcatagat gcccgttact atggcaacat cagccgcttc atcaaccacc tgtgtgaccc   3360

caacatcatt cccgtccggg tcttcatgct gcaccaagac ctgcgatttc cacgcatcgc   3420

cttcttcagt tcccgagaca tccggactgg ggaggagcta gggtttgact atggcgaccg   3480

cttctgggac atcaaaagca aatatttcac ctgccaatgt ggctctgaga agtgcaagca   3540

ctcagccgaa gccattgccc tggagcagag ccgtctggcc cgcctggacc cacaccctga   3600

gctgctgccc gagctcggct ccctgccccc tgtcaacaca tgagaacgga ccacaccctc   3660

tctccccagc atggatggcc acagctcagc cgcctcctct gccaccagct gctcgcagcc   3720

catgcctggg ggtgctgcca tcttctctcc ccaccaccct ttcacacatt cctgaccaga   3780

gatcccagcc aggccctgga ggtctgacag cccctccctc ccagagctgg ttcctccctg   3840

ggagggcaac ttcagggctg gccacccccc gtgttcccca tcctcagttg aagtttgatg   3900

aattgaagtc gggcctctat gccaactggt tccttttgtt ctcaataaat gttgggtttg   3960

gtaataaaaa aaaaaaaaaa aaaaaaaaaa aaaa                               3994


<210>  1619
<211>  1210
<212>  PRT
<213>  Homosapiens

<400>  1619

Met Ala Ala Ala Ala Gly Ala Ala Ala Ala Ala Ala Ala Glu Gly Glu 
1               5                   10                  15      


Ala Pro Ala Glu Met Gly Ala Leu Leu Leu Glu Lys Glu Thr Arg Gly 
            20                  25                  30          


Ala Thr Glu Arg Val His Gly Ser Leu Gly Asp Thr Pro Arg Ser Glu 
        35                  40                  45              


Glu Thr Leu Pro Lys Ala Asn Pro Asp Ser Leu Glu Pro Ala Gly Pro 
    50                  55                  60                  


Ser Ser Pro Ala Ser Val Thr Val Thr Val Gly Asp Glu Gly Ala Asp 
65                  70                  75                  80  


Thr Pro Val Gly Ala Thr Pro Leu Ile Gly Asp Glu Ser Glu Asn Leu 
                85                  90                  95      


Glu Gly Asp Gly Asp Leu Arg Gly Gly Arg Ile Leu Leu Gly His Ala 
            100                 105                 110         


Thr Lys Ser Phe Pro Ser Ser Pro Ser Lys Gly Gly Ser Cys Pro Ser 
        115                 120                 125             


Arg Ala Lys Met Ser Met Thr Gly Ala Gly Lys Ser Pro Pro Ser Val 
    130                 135                 140                 


Gln Ser Leu Ala Met Arg Leu Leu Ser Met Pro Gly Ala Gln Gly Ala 
145                 150                 155                 160 


Ala Ala Ala Gly Ser Glu Pro Pro Pro Ala Thr Thr Ser Pro Glu Gly 
                165                 170                 175     


Gln Pro Lys Val His Arg Ala Arg Lys Thr Met Ser Lys Pro Gly Asn 
            180                 185                 190         


Gly Gln Pro Pro Val Pro Glu Lys Arg Pro Pro Glu Ile Gln His Phe 
        195                 200                 205             


Arg Met Ser Asp Asp Val His Ser Leu Gly Lys Val Thr Ser Asp Leu 
    210                 215                 220                 


Ala Lys Arg Arg Lys Leu Asn Ser Gly Gly Gly Leu Ser Glu Glu Leu 
225                 230                 235                 240 


Gly Ser Ala Arg Arg Ser Gly Glu Val Thr Leu Thr Lys Gly Asp Pro 
                245                 250                 255     


Gly Ser Leu Glu Glu Trp Glu Thr Val Val Gly Asp Asp Phe Ser Leu 
            260                 265                 270         


Tyr Tyr Asp Ser Tyr Ser Val Asp Glu Arg Val Asp Ser Asp Ser Lys 
        275                 280                 285             


Ser Glu Val Glu Ala Leu Thr Glu Gln Leu Ser Glu Glu Glu Glu Glu 
    290                 295                 300                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
305                 310                 315                 320 


Glu Glu Glu Asp Glu Glu Ser Gly Asn Gln Ser Asp Arg Ser Gly Ser 
                325                 330                 335     


Ser Gly Arg Arg Lys Ala Lys Lys Lys Trp Arg Lys Asp Ser Pro Trp 
            340                 345                 350         


Val Lys Pro Ser Arg Lys Arg Arg Lys Arg Glu Pro Pro Arg Ala Lys 
        355                 360                 365             


Glu Pro Arg Gly Val Asn Gly Val Gly Ser Ser Gly Pro Ser Glu Tyr 
    370                 375                 380                 


Met Glu Val Pro Leu Gly Ser Leu Glu Leu Pro Ser Glu Gly Thr Leu 
385                 390                 395                 400 


Ser Pro Asn His Ala Gly Val Ser Asn Asp Thr Ser Ser Leu Glu Thr 
                405                 410                 415     


Glu Arg Gly Phe Glu Glu Leu Pro Leu Cys Ser Cys Arg Met Glu Ala 
            420                 425                 430         


Pro Lys Ile Asp Arg Ile Ser Glu Arg Ala Gly His Lys Cys Met Ala 
        435                 440                 445             


Thr Glu Ser Val Asp Gly Glu Leu Ser Gly Cys Asn Ala Ala Ile Leu 
    450                 455                 460                 


Lys Arg Glu Thr Met Arg Pro Ser Ser Arg Val Ala Leu Met Val Leu 
465                 470                 475                 480 


Cys Glu Thr His Arg Ala Arg Met Val Lys His His Cys Cys Pro Gly 
                485                 490                 495     


Cys Gly Tyr Phe Cys Thr Ala Gly Thr Phe Leu Glu Cys His Pro Asp 
            500                 505                 510         


Phe Arg Val Ala His Arg Phe His Lys Ala Cys Val Ser Gln Leu Asn 
        515                 520                 525             


Gly Met Val Phe Cys Pro His Cys Gly Glu Asp Ala Ser Glu Ala Gln 
    530                 535                 540                 


Glu Val Thr Ile Pro Arg Gly Asp Gly Val Thr Pro Pro Ala Gly Thr 
545                 550                 555                 560 


Ala Ala Pro Ala Pro Pro Pro Leu Ser Gln Asp Val Pro Gly Arg Ala 
                565                 570                 575     


Asp Thr Ser Gln Pro Ser Ala Arg Met Arg Gly His Gly Glu Pro Arg 
            580                 585                 590         


Arg Pro Pro Cys Asp Pro Leu Ala Asp Thr Ile Asp Ser Ser Gly Pro 
        595                 600                 605             


Ser Leu Thr Leu Pro Asn Gly Gly Cys Leu Ser Ala Val Gly Leu Pro 
    610                 615                 620                 


Leu Gly Pro Gly Arg Glu Ala Leu Glu Lys Ala Leu Val Ile Gln Glu 
625                 630                 635                 640 


Ser Glu Arg Arg Lys Lys Leu Arg Phe His Pro Arg Gln Leu Tyr Leu 
                645                 650                 655     


Ser Val Lys Gln Gly Glu Leu Gln Lys Val Ile Leu Met Leu Leu Asp 
            660                 665                 670         


Asn Leu Asp Pro Asn Phe Gln Ser Asp Gln Gln Ser Lys Arg Thr Pro 
        675                 680                 685             


Leu His Ala Ala Ala Gln Lys Gly Ser Val Glu Ile Cys His Val Leu 
    690                 695                 700                 


Leu Gln Ala Gly Ala Asn Ile Asn Ala Val Asp Lys Gln Gln Arg Thr 
705                 710                 715                 720 


Pro Leu Met Glu Ala Val Val Asn Asn His Leu Glu Val Ala Arg Tyr 
                725                 730                 735     


Met Val Gln Arg Gly Gly Cys Val Tyr Ser Lys Glu Glu Asp Gly Ser 
            740                 745                 750         


Thr Cys Leu His His Ala Ala Lys Ile Gly Asn Leu Glu Met Val Ser 
        755                 760                 765             


Leu Leu Leu Ser Thr Gly Gln Val Asp Val Asn Ala Gln Asp Ser Gly 
    770                 775                 780                 


Gly Trp Thr Pro Ile Ile Trp Ala Ala Glu His Lys His Ile Glu Val 
785                 790                 795                 800 


Ile Arg Met Leu Leu Thr Arg Gly Ala Asp Val Thr Leu Thr Asp Asn 
                805                 810                 815     


Glu Glu Asn Ile Cys Leu His Trp Ala Ser Phe Thr Gly Ser Ala Ala 
            820                 825                 830         


Ile Ala Glu Val Leu Leu Asn Ala Arg Cys Asp Leu His Ala Val Asn 
        835                 840                 845             


Tyr His Gly Asp Thr Pro Leu His Ile Ala Ala Arg Glu Ser Tyr His 
    850                 855                 860                 


Asp Cys Val Leu Leu Phe Leu Ser Arg Gly Ala Asn Pro Glu Leu Arg 
865                 870                 875                 880 


Asn Lys Glu Gly Asp Thr Ala Trp Asp Leu Thr Pro Glu Arg Ser Asp 
                885                 890                 895     


Val Trp Phe Ala Leu Gln Leu Asn Arg Lys Leu Arg Leu Gly Val Gly 
            900                 905                 910         


Asn Arg Ala Ile Arg Thr Glu Lys Ile Ile Cys Arg Asp Val Ala Arg 
        915                 920                 925             


Gly Tyr Glu Asn Val Pro Ile Pro Cys Val Asn Gly Val Asp Gly Glu 
    930                 935                 940                 


Pro Cys Pro Glu Asp Tyr Lys Tyr Ile Ser Glu Asn Cys Glu Thr Ser 
945                 950                 955                 960 


Thr Met Asn Ile Asp Arg Asn Ile Thr His Leu Gln His Cys Thr Cys 
                965                 970                 975     


Val Asp Asp Cys Ser Ser Ser Asn Cys Leu Cys Gly Gln Leu Ser Ile 
            980                 985                 990         


Arg Cys Trp Tyr Asp Lys Asp Gly  Arg Leu Leu Gln Glu  Phe Asn Lys 
        995                 1000                 1005             


Ile Glu  Pro Pro Leu Ile Phe  Glu Cys Asn Gln Ala  Cys Ser Cys 
    1010                 1015                 1020             


Trp Arg  Asn Cys Lys Asn Arg  Val Val Gln Ser Gly  Ile Lys Val 
    1025                 1030                 1035             


Arg Leu  Gln Leu Tyr Arg Thr  Ala Lys Met Gly Trp  Gly Val Arg 
    1040                 1045                 1050             


Ala Leu  Gln Thr Ile Pro Gln  Gly Thr Phe Ile Cys  Glu Tyr Val 
    1055                 1060                 1065             


Gly Glu  Leu Ile Ser Asp Ala  Glu Ala Asp Val Arg  Glu Asp Asp 
    1070                 1075                 1080             


Ser Tyr  Leu Phe Asp Leu Asp  Asn Lys Asp Gly Glu  Val Tyr Cys 
    1085                 1090                 1095             


Ile Asp  Ala Arg Tyr Tyr Gly  Asn Ile Ser Arg Phe  Ile Asn His 
    1100                 1105                 1110             


Leu Cys  Asp Pro Asn Ile Ile  Pro Val Arg Val Phe  Met Leu His 
    1115                 1120                 1125             


Gln Asp  Leu Arg Phe Pro Arg  Ile Ala Phe Phe Ser  Ser Arg Asp 
    1130                 1135                 1140             


Ile Arg  Thr Gly Glu Glu Leu  Gly Phe Asp Tyr Gly  Asp Arg Phe 
    1145                 1150                 1155             


Trp Asp  Ile Lys Ser Lys Tyr  Phe Thr Cys Gln Cys  Gly Ser Glu 
    1160                 1165                 1170             


Lys Cys  Lys His Ser Ala Glu  Ala Ile Ala Leu Glu  Gln Ser Arg 
    1175                 1180                 1185             


Leu Ala  Arg Leu Asp Pro His  Pro Glu Leu Leu Pro  Glu Leu Gly 
    1190                 1195                 1200             


Ser Leu  Pro Pro Val Asn Thr  
    1205                 1210 


<210>  1620
<211>  3892
<212>  DNA
<213>  Homosapiens

<400>  1620
gcaagcggcg atggcggcgg cggcgggagc tgcagcggcg gcggccgccg agggggaggc     60

ccccgctgag atgggggcgc tgctgctgga gaaggaaacc agaggagcca ccgagagagt    120

tcatggctct ttgggggaca cccctcgtag tgaagaaacc ctgcccaagg ccaaccccga    180

ctccctggag cctgctggcc cctcatctcc agcctctgtc actgtcactg ttggtgatga    240

gggggctgac acccctgtag gggctacacc actcattggg gatgaatctg agaatcttga    300

gggagatggg gacctccgtg ggggccggat cctgctgggc catgccacaa agtcattccc    360

ctcttccccc agcaaggggg gttcctgtcc tagccgggcc aagatgtcaa tgacaggggc    420

gggaaaatca cctccatctg tccagagttt ggctatgagg ctactgagta tgccaggagc    480

ccagggagct gcagcagcag ggtctgaacc ccctccagcc accacgagcc cagagggaca    540

gcccaaggtc caccgagccc gcaaaaccat gtccaaacca ggaaatggac agcccccggt    600

ccctgagaag cggccccctg aaatacagca tttccgcatg agtgatgatg tccactcact    660

gggaaaggtg acctcagatc tggccaaaag gaggaagctg aactcaggag gtggcctgtc    720

ggaggagtta ggttctgccc ggcgttcagg agaagtgacc ctgacgaaag gggaccccgg    780

gtccctggag gagtgggaga cggtggtggg tgatgacttc agtctctact atgattccta    840

ctctgtggat gagcgcgtgg actccgacag caagtctgaa gttgaagctc taactgaaca    900

actaagtgaa gaggaggagg aggaagagga ggaagaagaa gaagaggaag aggaggagga    960

agaggaagaa gaagaggaag atgaggagtc agggaatcag tcagatagga gtggttccag   1020

tggccggcgc aaggccaaga agaaatggcg aaaagacagc ccatgggtga agccgtctcg   1080

gaaacggcgc aagcgggagc ctccgcgggc caaggagcca cgaggagtgt ccaatgacac   1140

atcttcgctg gagacagagc gagggtttga ggagttgccc ctgtgcagct gccgcatgga   1200

ggcacccaag attgaccgca tcagcgagag ggcggggcac aagtgcatgg ccactgagag   1260

tgtggacgga gagctgtcag gctgcaatgc cgccatcctc aagcgggaga ccatgaggcc   1320

atccagccgt gtggccctga tggtgctctg tgagacccac cgcgcccgca tggtcaaaca   1380

ccactgctgc ccgggctgcg gctacttctg cacggcgggc accttcctgg agtgccaccc   1440

tgacttccgt gtggcccacc gcttccacaa ggcctgtgtg tctcagctga atgggatggt   1500

cttctgtccc cactgtgggg aggatgcttc tgaagctcaa gaggtgacca tcccccgggg   1560

tgacggggtg accccaccgg ccggcactgc agctcctgca cccccacccc tgtcccagga   1620

tgtccccggg agagcagaca cttctcagcc cagtgcccgg atgcgagggc atggggaacc   1680

ccggcgcccg ccctgcgatc ccctggctga caccattgac agctcagggc cctccctgac   1740

cctgcccaat gggggctgcc tttcagccgt ggggctgcca ctggggccag gccgggaggc   1800

cctggaaaag gccctggtca tccaggagtc agagaggcgg aagaagctcc gtttccaccc   1860

tcggcagttg tacctgtccg tgaagcaggg cgagctgcag aaggtgatcc tgatgctgtt   1920

ggacaacctg gaccccaact tccagagcga ccagcagagc aagcgcacgc ccctgcatgc   1980

agccgcccag aagggctccg tggagatctg ccatgtgctg ctgcaggctg gagccaacat   2040

aaatgcagtg gacaaacagc agcggacgcc actgatggag gccgtggtga acaaccacct   2100

ggaggtagcc cgttacatgg tgcagcgtgg tggctgtgtc tatagcaagg aggaggacgg   2160

ttccacctgc ctccaccacg cagccaaaat cgggaacttg gagatggtca gcctgctgct   2220

gagcacagga caggtggacg tcaacgccca ggacagtggg gggtggacgc ccatcatctg   2280

ggctgcagag cacaagcaca tcgaggtgat ccgcatgcta ctgacgcggg gcgccgacgt   2340

caccctcact gacaacgagg agaacatctg cctgcactgg gcctccttca cgggcagcgc   2400

cgccatcgcc gaagtccttc tgaatgcgcg ctgtgacctc catgctgtca actaccatgg   2460

ggacaccccc ctgcacatcg cagctcggga gagctaccat gactgcgtgc tgttattcct   2520

gtcacgtggg gccaaccctg agctgcggaa caaagagggg gacacagcat gggacctgac   2580

tcccgagcgc tccgacgtgt ggtttgcgct tcaactcaac cgcaagctcc gacttggggt   2640

gggaaatcgg gccatccgca cagagaagat catctgccgg gacgtggctc ggggctatga   2700

gaacgtgccc attccctgtg tcaacggtgt ggatggggag ccctgccctg aggattacaa   2760

gtacatctca gagaactgcg agacgtccac catgaacatc gatcgcaaca tcacccacct   2820

gcagcactgc acgtgtgtgg acgactgctc tagctccaac tgcctgtgcg gccagctcag   2880

catccggtgc tggtatgaca aggatgggcg attgctccag gaatttaaca agattgagcc   2940

tccgctgatt ttcgagtgta accaggcgtg ctcatgctgg agaaactgca agaaccgggt   3000

cgtacagagt ggcatcaagg tgcggctaca gctctaccga acagccaaga tgggctgggg   3060

ggtccgcgcc ctgcagacca tcccacaggg gaccttcatc tgcgagtatg tcggggagct   3120

gatctctgat gctgaggctg atgtgagaga ggatgattct tacctcttcg acttagacaa   3180

caaggatgga gaggtgtact gcatagatgc ccgttactat ggcaacatca gccgcttcat   3240

caaccacctg tgtgacccca acatcattcc cgtccgggtc ttcatgctgc accaagacct   3300

gcgatttcca cgcatcgcct tcttcagttc ccgagacatc cggactgggg aggagctagg   3360

gtttgactat ggcgaccgct tctgggacat caaaagcaaa tatttcacct gccaatgtgg   3420

ctctgagaag tgcaagcact cagccgaagc cattgccctg gagcagagcc gtctggcccg   3480

cctggaccca caccctgagc tgctgcccga gctcggctcc ctgccccctg tcaacacatg   3540

agaacggacc acaccctctc tccccagcat ggatggccac agctcagccg cctcctctgc   3600

caccagctgc tcgcagccca tgcctggggg tgctgccatc ttctctcccc accacccttt   3660

cacacattcc tgaccagaga tcccagccag gccctggagg tctgacagcc cctccctccc   3720

agagctggtt cctccctggg agggcaactt cagggctggc caccccccgt gttccccatc   3780

ctcagttgaa gtttgatgaa ttgaagtcgg gcctctatgc caactggttc cttttgttct   3840

caataaatgt tgggtttggt aataaaaaaa aaaaaaaaaa aaaaaaaaaa aa           3892


<210>  1621
<211>  1176
<212>  PRT
<213>  Homosapiens

<400>  1621

Met Ala Ala Ala Ala Gly Ala Ala Ala Ala Ala Ala Ala Glu Gly Glu 
1               5                   10                  15      


Ala Pro Ala Glu Met Gly Ala Leu Leu Leu Glu Lys Glu Thr Arg Gly 
            20                  25                  30          


Ala Thr Glu Arg Val His Gly Ser Leu Gly Asp Thr Pro Arg Ser Glu 
        35                  40                  45              


Glu Thr Leu Pro Lys Ala Asn Pro Asp Ser Leu Glu Pro Ala Gly Pro 
    50                  55                  60                  


Ser Ser Pro Ala Ser Val Thr Val Thr Val Gly Asp Glu Gly Ala Asp 
65                  70                  75                  80  


Thr Pro Val Gly Ala Thr Pro Leu Ile Gly Asp Glu Ser Glu Asn Leu 
                85                  90                  95      


Glu Gly Asp Gly Asp Leu Arg Gly Gly Arg Ile Leu Leu Gly His Ala 
            100                 105                 110         


Thr Lys Ser Phe Pro Ser Ser Pro Ser Lys Gly Gly Ser Cys Pro Ser 
        115                 120                 125             


Arg Ala Lys Met Ser Met Thr Gly Ala Gly Lys Ser Pro Pro Ser Val 
    130                 135                 140                 


Gln Ser Leu Ala Met Arg Leu Leu Ser Met Pro Gly Ala Gln Gly Ala 
145                 150                 155                 160 


Ala Ala Ala Gly Ser Glu Pro Pro Pro Ala Thr Thr Ser Pro Glu Gly 
                165                 170                 175     


Gln Pro Lys Val His Arg Ala Arg Lys Thr Met Ser Lys Pro Gly Asn 
            180                 185                 190         


Gly Gln Pro Pro Val Pro Glu Lys Arg Pro Pro Glu Ile Gln His Phe 
        195                 200                 205             


Arg Met Ser Asp Asp Val His Ser Leu Gly Lys Val Thr Ser Asp Leu 
    210                 215                 220                 


Ala Lys Arg Arg Lys Leu Asn Ser Gly Gly Gly Leu Ser Glu Glu Leu 
225                 230                 235                 240 


Gly Ser Ala Arg Arg Ser Gly Glu Val Thr Leu Thr Lys Gly Asp Pro 
                245                 250                 255     


Gly Ser Leu Glu Glu Trp Glu Thr Val Val Gly Asp Asp Phe Ser Leu 
            260                 265                 270         


Tyr Tyr Asp Ser Tyr Ser Val Asp Glu Arg Val Asp Ser Asp Ser Lys 
        275                 280                 285             


Ser Glu Val Glu Ala Leu Thr Glu Gln Leu Ser Glu Glu Glu Glu Glu 
    290                 295                 300                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
305                 310                 315                 320 


Glu Glu Glu Asp Glu Glu Ser Gly Asn Gln Ser Asp Arg Ser Gly Ser 
                325                 330                 335     


Ser Gly Arg Arg Lys Ala Lys Lys Lys Trp Arg Lys Asp Ser Pro Trp 
            340                 345                 350         


Val Lys Pro Ser Arg Lys Arg Arg Lys Arg Glu Pro Pro Arg Ala Lys 
        355                 360                 365             


Glu Pro Arg Gly Val Ser Asn Asp Thr Ser Ser Leu Glu Thr Glu Arg 
    370                 375                 380                 


Gly Phe Glu Glu Leu Pro Leu Cys Ser Cys Arg Met Glu Ala Pro Lys 
385                 390                 395                 400 


Ile Asp Arg Ile Ser Glu Arg Ala Gly His Lys Cys Met Ala Thr Glu 
                405                 410                 415     


Ser Val Asp Gly Glu Leu Ser Gly Cys Asn Ala Ala Ile Leu Lys Arg 
            420                 425                 430         


Glu Thr Met Arg Pro Ser Ser Arg Val Ala Leu Met Val Leu Cys Glu 
        435                 440                 445             


Thr His Arg Ala Arg Met Val Lys His His Cys Cys Pro Gly Cys Gly 
    450                 455                 460                 


Tyr Phe Cys Thr Ala Gly Thr Phe Leu Glu Cys His Pro Asp Phe Arg 
465                 470                 475                 480 


Val Ala His Arg Phe His Lys Ala Cys Val Ser Gln Leu Asn Gly Met 
                485                 490                 495     


Val Phe Cys Pro His Cys Gly Glu Asp Ala Ser Glu Ala Gln Glu Val 
            500                 505                 510         


Thr Ile Pro Arg Gly Asp Gly Val Thr Pro Pro Ala Gly Thr Ala Ala 
        515                 520                 525             


Pro Ala Pro Pro Pro Leu Ser Gln Asp Val Pro Gly Arg Ala Asp Thr 
    530                 535                 540                 


Ser Gln Pro Ser Ala Arg Met Arg Gly His Gly Glu Pro Arg Arg Pro 
545                 550                 555                 560 


Pro Cys Asp Pro Leu Ala Asp Thr Ile Asp Ser Ser Gly Pro Ser Leu 
                565                 570                 575     


Thr Leu Pro Asn Gly Gly Cys Leu Ser Ala Val Gly Leu Pro Leu Gly 
            580                 585                 590         


Pro Gly Arg Glu Ala Leu Glu Lys Ala Leu Val Ile Gln Glu Ser Glu 
        595                 600                 605             


Arg Arg Lys Lys Leu Arg Phe His Pro Arg Gln Leu Tyr Leu Ser Val 
    610                 615                 620                 


Lys Gln Gly Glu Leu Gln Lys Val Ile Leu Met Leu Leu Asp Asn Leu 
625                 630                 635                 640 


Asp Pro Asn Phe Gln Ser Asp Gln Gln Ser Lys Arg Thr Pro Leu His 
                645                 650                 655     


Ala Ala Ala Gln Lys Gly Ser Val Glu Ile Cys His Val Leu Leu Gln 
            660                 665                 670         


Ala Gly Ala Asn Ile Asn Ala Val Asp Lys Gln Gln Arg Thr Pro Leu 
        675                 680                 685             


Met Glu Ala Val Val Asn Asn His Leu Glu Val Ala Arg Tyr Met Val 
    690                 695                 700                 


Gln Arg Gly Gly Cys Val Tyr Ser Lys Glu Glu Asp Gly Ser Thr Cys 
705                 710                 715                 720 


Leu His His Ala Ala Lys Ile Gly Asn Leu Glu Met Val Ser Leu Leu 
                725                 730                 735     


Leu Ser Thr Gly Gln Val Asp Val Asn Ala Gln Asp Ser Gly Gly Trp 
            740                 745                 750         


Thr Pro Ile Ile Trp Ala Ala Glu His Lys His Ile Glu Val Ile Arg 
        755                 760                 765             


Met Leu Leu Thr Arg Gly Ala Asp Val Thr Leu Thr Asp Asn Glu Glu 
    770                 775                 780                 


Asn Ile Cys Leu His Trp Ala Ser Phe Thr Gly Ser Ala Ala Ile Ala 
785                 790                 795                 800 


Glu Val Leu Leu Asn Ala Arg Cys Asp Leu His Ala Val Asn Tyr His 
                805                 810                 815     


Gly Asp Thr Pro Leu His Ile Ala Ala Arg Glu Ser Tyr His Asp Cys 
            820                 825                 830         


Val Leu Leu Phe Leu Ser Arg Gly Ala Asn Pro Glu Leu Arg Asn Lys 
        835                 840                 845             


Glu Gly Asp Thr Ala Trp Asp Leu Thr Pro Glu Arg Ser Asp Val Trp 
    850                 855                 860                 


Phe Ala Leu Gln Leu Asn Arg Lys Leu Arg Leu Gly Val Gly Asn Arg 
865                 870                 875                 880 


Ala Ile Arg Thr Glu Lys Ile Ile Cys Arg Asp Val Ala Arg Gly Tyr 
                885                 890                 895     


Glu Asn Val Pro Ile Pro Cys Val Asn Gly Val Asp Gly Glu Pro Cys 
            900                 905                 910         


Pro Glu Asp Tyr Lys Tyr Ile Ser Glu Asn Cys Glu Thr Ser Thr Met 
        915                 920                 925             


Asn Ile Asp Arg Asn Ile Thr His Leu Gln His Cys Thr Cys Val Asp 
    930                 935                 940                 


Asp Cys Ser Ser Ser Asn Cys Leu Cys Gly Gln Leu Ser Ile Arg Cys 
945                 950                 955                 960 


Trp Tyr Asp Lys Asp Gly Arg Leu Leu Gln Glu Phe Asn Lys Ile Glu 
                965                 970                 975     


Pro Pro Leu Ile Phe Glu Cys Asn Gln Ala Cys Ser Cys Trp Arg Asn 
            980                 985                 990         


Cys Lys Asn Arg Val Val Gln Ser  Gly Ile Lys Val Arg  Leu Gln Leu 
        995                 1000                 1005             


Tyr Arg  Thr Ala Lys Met Gly  Trp Gly Val Arg Ala  Leu Gln Thr 
    1010                 1015                 1020             


Ile Pro  Gln Gly Thr Phe Ile  Cys Glu Tyr Val Gly  Glu Leu Ile 
    1025                 1030                 1035             


Ser Asp  Ala Glu Ala Asp Val  Arg Glu Asp Asp Ser  Tyr Leu Phe 
    1040                 1045                 1050             


Asp Leu  Asp Asn Lys Asp Gly  Glu Val Tyr Cys Ile  Asp Ala Arg 
    1055                 1060                 1065             


Tyr Tyr  Gly Asn Ile Ser Arg  Phe Ile Asn His Leu  Cys Asp Pro 
    1070                 1075                 1080             


Asn Ile  Ile Pro Val Arg Val  Phe Met Leu His Gln  Asp Leu Arg 
    1085                 1090                 1095             


Phe Pro  Arg Ile Ala Phe Phe  Ser Ser Arg Asp Ile  Arg Thr Gly 
    1100                 1105                 1110             


Glu Glu  Leu Gly Phe Asp Tyr  Gly Asp Arg Phe Trp  Asp Ile Lys 
    1115                 1120                 1125             


Ser Lys  Tyr Phe Thr Cys Gln  Cys Gly Ser Glu Lys  Cys Lys His 
    1130                 1135                 1140             


Ser Ala  Glu Ala Ile Ala Leu  Glu Gln Ser Arg Leu  Ala Arg Leu 
    1145                 1150                 1155             


Asp Pro  His Pro Glu Leu Leu  Pro Glu Leu Gly Ser  Leu Pro Pro 
    1160                 1165                 1170             


Val Asn  Thr 
    1175     


<210>  1622
<211>  1931
<212>  DNA
<213>  Homosapiens

<400>  1622
cgcccacgcg gagccggccc cgcgcgcgcg cgcgtcccgt gcatccccgc gcctgcgcgc     60

tgcccaggcc ctgcccgtgt gtgggggtcg ctgccgaccc cggggggggg tggggaaaat    120

aagggattaa aaaaacagcg cgcggaaccg ggccagggtt gcccaccccc gccacaatgg    180

cctctggggt ggaagtcctg cgcttccagc tgcccggcca cgaggccgca acgctacgga    240

acatgaacca gctccgggca gaggagcggt tctgcgacgt gaccattgtg gccgacagcc    300

tcaagtttcg aggccacaag gtcatcttgg ccgcctgctc acccttcctg cgggaccagt    360

tcctgctgaa ccccagctcg gagctgcagg tctccctgat gcacagtgca cgcatcgtgg    420

ccgacttgct cctctcctgc tacacgggcg ccttggaatt cgctgttagg gacatcgtca    480

actaccttac agccgcctcc tacctgcaga tggagcacgt ggtggagaaa tgccggaatg    540

ccctcagcca gttcattgag cccaaaatag gcctcaaaga ggatggggtc agtgaggcta    600

gccttgtgag cagcatcagc gccaccaagt ccctcctccc tccagccagg accccaaagc    660

cagccccgaa gcccccaccc ccacctcctc taccccctcc actcctgcgg ccagtgaagc    720

tggagttccc actggatgaa gacttggagc tgaaagccga ggaagaggat gaggatgagg    780

atgaggacgt gtctgacatc tgcatcgtca aggtggagtc ggccctggag gtggcacacc    840

ggctcaaacc ccctggaggc ctgggagggg gtctgggcat tggaggctcc gtgggtggcc    900

accttgggga gctggcccag agcagcgttc cccccagcac tgtagcccca ccgcagggtg    960

tggtgaaggc ctgctatagc ctgtcggaag atgcagaagg ggagggcctg ctgttgattc   1020

ccggaggccg ggccagcgtg ggggccacct cgggcctggt ggaagcagca gcggtggcca   1080

tggctgcccg gggggcgggg ggcagcctgg gggcgggggg cagccgggga cccctgcctg   1140

ggggcttctc aggtggaaac cccttaaaga acatcaagtg caccaagtgc ccggaagtgt   1200

tccagggcgt ggagaagctg gtcttccaca tgcgggcgca gcacttcatc ttcatgtgcc   1260

ctcgctgtgg caagcagttc aaccacagca gcaacctcaa ccgccacatg aacgtgcatc   1320

gtggtgtcaa gtcacactcg tgcggcatct gcggcaagtg cttcacacag aagtccaccc   1380

ttcacgacca cctcaacctg cactcgggag cgcggcccta ccgctgctcc tactgcgacg   1440

tgcgcttcgc ccacaagcct gccattaggc ggcacctcaa ggagcaacac ggcaagacca   1500

cggccgagaa cgtgctggag gccagtgtgg ccgagattaa cgtcctcatc cgctagccgc   1560

gcaggcgtgg aggccaggag gctggggccc ctgggctgcg tggaaaaagg gctctttggc   1620

ccaggagaat tggggggtgg ggggtctggg gcagaaaggt aagagtggga ggctgagcag   1680

atgcacacat cctgagagag ggaagatgat tccttggaga gacttgctct tgagagtgca   1740

agaatctgga gctgggaaaa gggttcttgg aggccagggg aatacggggt cccagagaaa   1800

gatttccttc tcttagaagt gcatgtatat gtggagggag ggaaaagggt cctatagaat   1860

ggggggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1920

aaaaaaaaaa a                                                        1931


<210>  1623
<211>  459
<212>  PRT
<213>  Homosapiens

<400>  1623

Met Ala Ser Gly Val Glu Val Leu Arg Phe Gln Leu Pro Gly His Glu 
1               5                   10                  15      


Ala Ala Thr Leu Arg Asn Met Asn Gln Leu Arg Ala Glu Glu Arg Phe 
            20                  25                  30          


Cys Asp Val Thr Ile Val Ala Asp Ser Leu Lys Phe Arg Gly His Lys 
        35                  40                  45              


Val Ile Leu Ala Ala Cys Ser Pro Phe Leu Arg Asp Gln Phe Leu Leu 
    50                  55                  60                  


Asn Pro Ser Ser Glu Leu Gln Val Ser Leu Met His Ser Ala Arg Ile 
65                  70                  75                  80  


Val Ala Asp Leu Leu Leu Ser Cys Tyr Thr Gly Ala Leu Glu Phe Ala 
                85                  90                  95      


Val Arg Asp Ile Val Asn Tyr Leu Thr Ala Ala Ser Tyr Leu Gln Met 
            100                 105                 110         


Glu His Val Val Glu Lys Cys Arg Asn Ala Leu Ser Gln Phe Ile Glu 
        115                 120                 125             


Pro Lys Ile Gly Leu Lys Glu Asp Gly Val Ser Glu Ala Ser Leu Val 
    130                 135                 140                 


Ser Ser Ile Ser Ala Thr Lys Ser Leu Leu Pro Pro Ala Arg Thr Pro 
145                 150                 155                 160 


Lys Pro Ala Pro Lys Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Leu 
                165                 170                 175     


Leu Arg Pro Val Lys Leu Glu Phe Pro Leu Asp Glu Asp Leu Glu Leu 
            180                 185                 190         


Lys Ala Glu Glu Glu Asp Glu Asp Glu Asp Glu Asp Val Ser Asp Ile 
        195                 200                 205             


Cys Ile Val Lys Val Glu Ser Ala Leu Glu Val Ala His Arg Leu Lys 
    210                 215                 220                 


Pro Pro Gly Gly Leu Gly Gly Gly Leu Gly Ile Gly Gly Ser Val Gly 
225                 230                 235                 240 


Gly His Leu Gly Glu Leu Ala Gln Ser Ser Val Pro Pro Ser Thr Val 
                245                 250                 255     


Ala Pro Pro Gln Gly Val Val Lys Ala Cys Tyr Ser Leu Ser Glu Asp 
            260                 265                 270         


Ala Glu Gly Glu Gly Leu Leu Leu Ile Pro Gly Gly Arg Ala Ser Val 
        275                 280                 285             


Gly Ala Thr Ser Gly Leu Val Glu Ala Ala Ala Val Ala Met Ala Ala 
    290                 295                 300                 


Arg Gly Ala Gly Gly Ser Leu Gly Ala Gly Gly Ser Arg Gly Pro Leu 
305                 310                 315                 320 


Pro Gly Gly Phe Ser Gly Gly Asn Pro Leu Lys Asn Ile Lys Cys Thr 
                325                 330                 335     


Lys Cys Pro Glu Val Phe Gln Gly Val Glu Lys Leu Val Phe His Met 
            340                 345                 350         


Arg Ala Gln His Phe Ile Phe Met Cys Pro Arg Cys Gly Lys Gln Phe 
        355                 360                 365             


Asn His Ser Ser Asn Leu Asn Arg His Met Asn Val His Arg Gly Val 
    370                 375                 380                 


Lys Ser His Ser Cys Gly Ile Cys Gly Lys Cys Phe Thr Gln Lys Ser 
385                 390                 395                 400 


Thr Leu His Asp His Leu Asn Leu His Ser Gly Ala Arg Pro Tyr Arg 
                405                 410                 415     


Cys Ser Tyr Cys Asp Val Arg Phe Ala His Lys Pro Ala Ile Arg Arg 
            420                 425                 430         


His Leu Lys Glu Gln His Gly Lys Thr Thr Ala Glu Asn Val Leu Glu 
        435                 440                 445             


Ala Ser Val Ala Glu Ile Asn Val Leu Ile Arg 
    450                 455                 


<210>  1624
<211>  2609
<212>  DNA
<213>  Homosapiens

<400>  1624
ggctctctac ctctcgccgc ccctagggag gacaccatgg gcccactgat ggttcttttt     60

tgcctgctgt tcctgtaccc aggtctggca gactcggctc cctcctgccc tcagaacgtg    120

aatatctcgg gtggcacctt caccctcagc catggctggg ctcctgggag ccttctcacc    180

tactcctgcc cccagggcct gtacccatcc ccagcatcac ggctgtgcaa gagcagcgga    240

cagtggcaga ccccaggagc cacccggtct ctgtctaagg cggtctgcaa acctgtgcgc    300

tgtccagccc ctgtctcctt tgagaatggc atttataccc cacggctggg gtcctatccc    360

gtgggtggca atgtgagctt cgagtgtgag gatggcttca tattgcgggg ctcgcctgtg    420

cgtcagtgtc gccccaacgg catgtgggat ggagaaacag ctgtgtgtga taatggggct    480

ggccactgcc ccaacccagg catttcactg ggcgcagtgc ggacaggctt ccgctttggt    540

catggggaca aggtccgcta tcgctgctcc tcgaatcttg tgctcacggg gtcttcggag    600

cgggagtgcc agggcaacgg ggtctggagt ggaacggagc ccatctgccg ccaaccctac    660

tcttatgact tccctgagga cgtggcccct gccctgggca cttccttctc ccacatgctt    720

ggggccacca atcccaccca gaagacaaag gaaagcctgg gccgtaaaat ccaaatccag    780

cgctctggtc atctgaacct ctacctgctc ctggactgtt cgcagagtgt gtcggaaaat    840

gactttctca tcttcaagga gagcgcctcc ctcatggtgg acaggatctt cagctttgag    900

atcaatgtga gcgttgccat tatcaccttt gcctcagagc ccaaagtcct catgtctgtc    960

ctgaacgaca actcccggga tatgactgag gtgatcagca gcctggaaaa tgccaactat   1020

aaagatcatg aaaatggaac tgggactaac acctatgcag ccttaaacag tgtctatctc   1080

atgatgaaca accaaatgcg actcctcggc atggaaacga tggcctggca ggaaatccga   1140

catgccatca tccttctgac agatggaaag tccaatatgg gtggctctcc caagacagct   1200

gttgaccata tcagagagat cctgaacatc aaccagaaga ggaatgacta tctggacatc   1260

tatgccatcg gggtgggcaa gctggatgtg gactggagag aactgaatga gctagggtcc   1320

aagaaggatg gtgagaggca tgccttcatt ctgcaggaca caaaggctct gcaccaggtc   1380

tttgaacata tgctggatgt ctccaagctc acagacacca tctgcggggt ggggaacatg   1440

tcagcaaacg cctctgacca ggagaggaca ccctggcatg tcactattaa gcccaagagc   1500

caagagacct gccggggggc cctcatctcc gaccaatggg tcctgacagc agctcattgc   1560

ttccgcgatg gcaacgacca ctccctgtgg agggtcaatg tgggagaccc caaatcccag   1620

tggggcaaag aattccttat tgagaaggcg gtgatctccc cagggtttga tgtctttgcc   1680

aaaaagaacc agggaatcct ggagttctat ggtgatgaca tagctctgct gaagctggcc   1740

cagaaagtaa agatgtccac ccatgccagg cccatctgcc ttccctgcac gatggaggcc   1800

aatctggctc tgcggagacc tcaaggcagc acctgtaggg accatgagaa tgaactgctg   1860

aacaaacaga gtgttcctgc tcattttgtc gccttgaatg ggagcaaact gaacattaac   1920

cttaagatgg gagtggagtg gacaagctgt gccgaggttg tctcccaaga aaaaaccatg   1980

ttccccaact tgacagatgt cagggaggtg gtgacagacc agttcctatg cagtgggacc   2040

caggaggatg agagtccctg caagggagaa tctgggggag cagttttcct tgagcggaga   2100

ttcaggtttt ttcaggtggg tctggtgagc tggggtcttt acaacccctg ccttggctct   2160

gctgacaaaa actcccgcaa aagggcccct cgtagcaagg tcccgccgcc acgagacttt   2220

cacatcaatc tcttccgcat gcagccctgg ctgaggcagc acctggggga tgtcctgaat   2280

tttttacccc tctagccatg gccactgagc cctctgctgc cctgccagaa tctgccgccc   2340

ctccatcttc tacctctgaa tggccaccct tagaccctgt gatccatcct ctctcctagc   2400

tgagtaaatc cgggtctcta ggatgccaga ggcagcgcac acaagctggg aaatcctcag   2460

ggctcctacc agcaggactg cctcgctgcc ccacctcccg ctccttggcc tgtccccaga   2520

ttccttccct ggttgacttg actcatgctt gtttcacttt cacatggaat ttcccagtta   2580

tgaaattaat aaaaatcaat ggtttccac                                     2609


<210>  1625
<211>  752
<212>  PRT
<213>  Homosapiens

<400>  1625

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly 
            20                  25                  30          


Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr 
        35                  40                  45              


Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu Cys 
    50                  55                  60                  


Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg Ser Leu Ser 
65                  70                  75                  80  


Lys Ala Val Cys Lys Pro Val Arg Cys Pro Ala Pro Val Ser Phe Glu 
                85                  90                  95      


Asn Gly Ile Tyr Thr Pro Arg Leu Gly Ser Tyr Pro Val Gly Gly Asn 
            100                 105                 110         


Val Ser Phe Glu Cys Glu Asp Gly Phe Ile Leu Arg Gly Ser Pro Val 
        115                 120                 125             


Arg Gln Cys Arg Pro Asn Gly Met Trp Asp Gly Glu Thr Ala Val Cys 
    130                 135                 140                 


Asp Asn Gly Ala Gly His Cys Pro Asn Pro Gly Ile Ser Leu Gly Ala 
145                 150                 155                 160 


Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp Lys Val Arg Tyr Arg 
                165                 170                 175     


Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser Glu Arg Glu Cys Gln 
            180                 185                 190         


Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile Cys Arg Gln Pro Tyr 
        195                 200                 205             


Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala Leu Gly Thr Ser Phe 
    210                 215                 220                 


Ser His Met Leu Gly Ala Thr Asn Pro Thr Gln Lys Thr Lys Glu Ser 
225                 230                 235                 240 


Leu Gly Arg Lys Ile Gln Ile Gln Arg Ser Gly His Leu Asn Leu Tyr 
                245                 250                 255     


Leu Leu Leu Asp Cys Ser Gln Ser Val Ser Glu Asn Asp Phe Leu Ile 
            260                 265                 270         


Phe Lys Glu Ser Ala Ser Leu Met Val Asp Arg Ile Phe Ser Phe Glu 
        275                 280                 285             


Ile Asn Val Ser Val Ala Ile Ile Thr Phe Ala Ser Glu Pro Lys Val 
    290                 295                 300                 


Leu Met Ser Val Leu Asn Asp Asn Ser Arg Asp Met Thr Glu Val Ile 
305                 310                 315                 320 


Ser Ser Leu Glu Asn Ala Asn Tyr Lys Asp His Glu Asn Gly Thr Gly 
                325                 330                 335     


Thr Asn Thr Tyr Ala Ala Leu Asn Ser Val Tyr Leu Met Met Asn Asn 
            340                 345                 350         


Gln Met Arg Leu Leu Gly Met Glu Thr Met Ala Trp Gln Glu Ile Arg 
        355                 360                 365             


His Ala Ile Ile Leu Leu Thr Asp Gly Lys Ser Asn Met Gly Gly Ser 
    370                 375                 380                 


Pro Lys Thr Ala Val Asp His Ile Arg Glu Ile Leu Asn Ile Asn Gln 
385                 390                 395                 400 


Lys Arg Asn Asp Tyr Leu Asp Ile Tyr Ala Ile Gly Val Gly Lys Leu 
                405                 410                 415     


Asp Val Asp Trp Arg Glu Leu Asn Glu Leu Gly Ser Lys Lys Asp Gly 
            420                 425                 430         


Glu Arg His Ala Phe Ile Leu Gln Asp Thr Lys Ala Leu His Gln Val 
        435                 440                 445             


Phe Glu His Met Leu Asp Val Ser Lys Leu Thr Asp Thr Ile Cys Gly 
    450                 455                 460                 


Val Gly Asn Met Ser Ala Asn Ala Ser Asp Gln Glu Arg Thr Pro Trp 
465                 470                 475                 480 


His Val Thr Ile Lys Pro Lys Ser Gln Glu Thr Cys Arg Gly Ala Leu 
                485                 490                 495     


Ile Ser Asp Gln Trp Val Leu Thr Ala Ala His Cys Phe Arg Asp Gly 
            500                 505                 510         


Asn Asp His Ser Leu Trp Arg Val Asn Val Gly Asp Pro Lys Ser Gln 
        515                 520                 525             


Trp Gly Lys Glu Phe Leu Ile Glu Lys Ala Val Ile Ser Pro Gly Phe 
    530                 535                 540                 


Asp Val Phe Ala Lys Lys Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp 
545                 550                 555                 560 


Asp Ile Ala Leu Leu Lys Leu Ala Gln Lys Val Lys Met Ser Thr His 
                565                 570                 575     


Ala Arg Pro Ile Cys Leu Pro Cys Thr Met Glu Ala Asn Leu Ala Leu 
            580                 585                 590         


Arg Arg Pro Gln Gly Ser Thr Cys Arg Asp His Glu Asn Glu Leu Leu 
        595                 600                 605             


Asn Lys Gln Ser Val Pro Ala His Phe Val Ala Leu Asn Gly Ser Lys 
    610                 615                 620                 


Leu Asn Ile Asn Leu Lys Met Gly Val Glu Trp Thr Ser Cys Ala Glu 
625                 630                 635                 640 


Val Val Ser Gln Glu Lys Thr Met Phe Pro Asn Leu Thr Asp Val Arg 
                645                 650                 655     


Glu Val Val Thr Asp Gln Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu 
            660                 665                 670         


Ser Pro Cys Lys Gly Glu Ser Gly Gly Ala Val Phe Leu Glu Arg Arg 
        675                 680                 685             


Phe Arg Phe Phe Gln Val Gly Leu Val Ser Trp Gly Leu Tyr Asn Pro 
    690                 695                 700                 


Cys Leu Gly Ser Ala Asp Lys Asn Ser Arg Lys Arg Ala Pro Arg Ser 
705                 710                 715                 720 


Lys Val Pro Pro Pro Arg Asp Phe His Ile Asn Leu Phe Arg Met Gln 
                725                 730                 735     


Pro Trp Leu Arg Gln His Leu Gly Asp Val Leu Asn Phe Leu Pro Leu 
            740                 745                 750         


<210>  1626
<211>  2574
<212>  DNA
<213>  Homosapiens

<400>  1626
ttggatgttc cgggaaagtg atgtgggtag gacaggcggg gcgagccgca ggtgccagaa     60

cacagattgt ataaaaggct gggggctggt ggggagcagg ggaagggaat gtgaccaggt    120

ctaggtctgg agtttcagct tggacactga gccaagcaga caagcaaagc aagccaggac    180

acaccatcct gccccaggcc cagcttctct cctgccttcc aacgccatgg ggagcaatct    240

cagcccccaa ctctgcctga tgccctttat cttgggcctc ttgtctggag gtgtgaccac    300

cactccatgg tctttggccc ggccccaggg atcctgctct ctggaggggg tagagatcaa    360

aggcggctcc ttccgacttc tccaagaggg ccaggcactg gagtacgtgt gtccttctgg    420

cttctacccg taccctgtgc agacacgtac ctgcagatct acggggtcct ggagcaccct    480

gaagactcaa gaccaaaaga ctgtcaggaa ggcagagtgc agagcaatcc actgtccaag    540

accacacgac ttcgagaacg gggaatactg gccccggtct ccctactaca atgtgagtga    600

tgagatctct ttccactgct atgacggtta cactctccgg ggctctgcca atcgcacctg    660

ccaagtgaat ggccgatgga gtgggcagac agcgatctgt gacaacggag cggggtactg    720

ctccaacccg ggcatcccca ttggcacaag gaaggtgggc agccagtacc gccttgaaga    780

cagcgtcacc taccactgca gccgggggct taccctgcgt ggctcccagc ggcgaacgtg    840

tcaggaaggt ggctcttgga gcgggacgga gccttcctgc caagactcct tcatgtacga    900

cacccctcaa gaggtggccg aagctttcct gtcttccctg acagagacca tagaaggagt    960

cgatgctgag gatgggcacg gcccagggga acaacagaag cggaagatcg tcctggaccc   1020

ttcaggctcc atgaacatct acctggtgct agatggatca gacagcattg gggccagcaa   1080

cttcacagga gccaaaaagt gtctagtcaa cttaattgag aaggtggcaa gttatggtgt   1140

gaagccaaga tatggtctag tgacatatgc cacatacccc aaaatttggg tcaaagtgtc   1200

tgaagcagac agcagtaatg cagactgggt cacgaagcag ctcaatgaaa tcaattatga   1260

agaccacaag ttgaagtcag ggactaacac caagaaggcc ctccaggcag tgtacagcat   1320

gatgagctgg ccagatgacg tccctcctga aggctggaac cgcacccgcc atgtcatcat   1380

cctcatgact gatggattgc acaacatggg cggggaccca attactgtca ttgatgagat   1440

ccgggacttg ctatacattg gcaaggatcg caaaaaccca agggaggatt atctggatgt   1500

ctatgtgttt ggggtcgggc ctttggtgaa ccaagtgaac atcaatgctt tggcttccaa   1560

gaaagacaat gagcaacatg tgttcaaagt caaggatatg gaaaacctgg aagatgtttt   1620

ctaccaaatg atcgatgaaa gccagtctct gagtctctgt ggcatggttt gggaacacag   1680

gaagggtacc gattaccaca agcaaccatg gcaggccaag atctcagtca ttcgcccttc   1740

aaagggacac gagagctgta tgggggctgt ggtgtctgag tactttgtgc tgacagcagc   1800

acattgtttc actgtggatg acaaggaaca ctcaatcaag gtcagcgtag gaggggagaa   1860

gcgggacctg gagatagaag tagtcctatt tcaccccaac tacaacatta atgggaaaaa   1920

agaagcagga attcctgaat tttatgacta tgacgttgcc ctgatcaagc tcaagaataa   1980

gctgaaatat ggccagacta tcaggcccat ttgtctcccc tgcaccgagg gaacaactcg   2040

agctttgagg cttcctccaa ctaccacttg ccagcaacaa aaggaagagc tgctccctgc   2100

acaggatatc aaagctctgt ttgtgtctga ggaggagaaa aagctgactc ggaaggaggt   2160

ctacatcaag aatggggata agaaaggcag ctgtgagaga gatgctcaat atgccccagg   2220

ctatgacaaa gtcaaggaca tctcagaggt ggtcacccct cggttccttt gtactggagg   2280

agtgagtccc tatgctgacc ccaatacttg cagaggtgat tctggcggcc ccttgatagt   2340

tcacaagaga agtcgtttca ttcaagttgg tgtaatcagc tggggagtag tggatgtctg   2400

caaaaaccag aagcggcaaa agcaggtacc tgctcacgcc cgagactttc acatcaacct   2460

ctttcaagtg ctgccctggc tgaaggagaa actccaagat gaggatttgg gttttctata   2520

aggggtttcc tgctggacag gggcgtggga ttgaattaaa acagctgcga caac         2574


<210>  1627
<211>  764
<212>  PRT
<213>  Homosapiens

<400>  1627

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210>  1628
<211>  1568
<212>  DNA
<213>  Homosapiens

<400>  1628
gccccgccga gagcgtgaac tatcgctgcg gaggggcaga cctggaccgg tggaaggccg     60

ggcggaagtg cgcgcctggg gccgccttgg ttaccgcgtt ttccgctcct cgctacgtca    120

tcgttgtgag cccgctatca gcggccagcg cgggcgcggc cggagaccgt ggggcccccg    180

gttgccgccc cctcgggagc caccatgttg gtgatacccc ccggactgag cgaggaagag    240

gaggctctgc agaagaaatt caacaagctc aagaaaaaga aaaaggcatt gctggctctg    300

aagaagcaaa gtagcagcag cacaaccagc caaggtggtg tcaaacgctc actatcagag    360

cagcctgtca tggacacagc cacagcaaca gagcaggcaa agcagctggt gaagtcagga    420

gccatcagtg ccatcaaggc tgagaccaag aactcaggct tcaagcgttc tcgaaccctt    480

gaggggaagt taaaggaccc cgagaaggga ccagtcccca ctttccagcc gttccagagg    540

agcatatctg ctgatgatga cctgcaagag tcatccagac gtccccagag gaaatctctg    600

tatgagagct ttgtgtcttc tagtgatcga cttcgagaac taggaccaga tggagaagag    660

gcagagggcc caggggctgg tgatggtccc cctcgaagct ttgactgggg ctatgaagaa    720

cgcagtggtg cccactcctc agcctcccct ccccgaagcc gcagccggga ccgcagccat    780

gagaggaacc gggacagaga ccgagatcgg gagcgggatc gagaccggga tcgagacaga    840

gacagagagc gggacaggga tcgggatcgg gatcgagatc gagaccggga acgggacagg    900

gatcgggagc gggatcgaga ccgagaccga gagggtcctt tccgcaggtc ggattcattc    960

cctgaacggc gagcccctag gaaagggaat actctctatg tatatggaga agacatgaca   1020

cccacccttc tccgtggggc cttctctcct tttggaaaca tcattgacct ctccatggac   1080

ccacccagaa actgtgcctt cgtcacctat gaaaagatgg agtcagcaga tcaggccgtt   1140

gctgagctca acgggaccca ggtggagtct gtacagctca aagtcaacat agcccgaaaa   1200

cagcccatgc tggatgccgc tactggcaag tctgtctggg gctccctcgc tgtccagaac   1260

agccctaagg gttgccaccg ggacaagagg acccagattg tctacagtga tgacgtctac   1320

aaggaaaacc ttgtggatgg cttctaggga acagagctgg attccttgtg cctcatatgc   1380

cccaatgctg gtctcagtaa aacactgagg tggaagctta cacatctccc tcagcctctg   1440

gtttttcagc acttgggatt ggggttaaac ctttaaaaac ggctgtcagg tttgatctca   1500

gtgtaacaac atggccagtg cctgttcccc actcccttgc cccaaaagga tctggaacac   1560

aaaaaaaa                                                            1568


<210>  1629
<211>  380
<212>  PRT
<213>  Homosapiens

<400>  1629

Met Leu Val Ile Pro Pro Gly Leu Ser Glu Glu Glu Glu Ala Leu Gln 
1               5                   10                  15      


Lys Lys Phe Asn Lys Leu Lys Lys Lys Lys Lys Ala Leu Leu Ala Leu 
            20                  25                  30          


Lys Lys Gln Ser Ser Ser Ser Thr Thr Ser Gln Gly Gly Val Lys Arg 
        35                  40                  45              


Ser Leu Ser Glu Gln Pro Val Met Asp Thr Ala Thr Ala Thr Glu Gln 
    50                  55                  60                  


Ala Lys Gln Leu Val Lys Ser Gly Ala Ile Ser Ala Ile Lys Ala Glu 
65                  70                  75                  80  


Thr Lys Asn Ser Gly Phe Lys Arg Ser Arg Thr Leu Glu Gly Lys Leu 
                85                  90                  95      


Lys Asp Pro Glu Lys Gly Pro Val Pro Thr Phe Gln Pro Phe Gln Arg 
            100                 105                 110         


Ser Ile Ser Ala Asp Asp Asp Leu Gln Glu Ser Ser Arg Arg Pro Gln 
        115                 120                 125             


Arg Lys Ser Leu Tyr Glu Ser Phe Val Ser Ser Ser Asp Arg Leu Arg 
    130                 135                 140                 


Glu Leu Gly Pro Asp Gly Glu Glu Ala Glu Gly Pro Gly Ala Gly Asp 
145                 150                 155                 160 


Gly Pro Pro Arg Ser Phe Asp Trp Gly Tyr Glu Glu Arg Ser Gly Ala 
                165                 170                 175     


His Ser Ser Ala Ser Pro Pro Arg Ser Arg Ser Arg Asp Arg Ser His 
            180                 185                 190         


Glu Arg Asn Arg Asp Arg Asp Arg Asp Arg Glu Arg Asp Arg Asp Arg 
        195                 200                 205             


Asp Arg Asp Arg Asp Arg Glu Arg Asp Arg Asp Arg Asp Arg Asp Arg 
    210                 215                 220                 


Asp Arg Asp Arg Glu Arg Asp Arg Asp Arg Glu Arg Asp Arg Asp Arg 
225                 230                 235                 240 


Asp Arg Glu Gly Pro Phe Arg Arg Ser Asp Ser Phe Pro Glu Arg Arg 
                245                 250                 255     


Ala Pro Arg Lys Gly Asn Thr Leu Tyr Val Tyr Gly Glu Asp Met Thr 
            260                 265                 270         


Pro Thr Leu Leu Arg Gly Ala Phe Ser Pro Phe Gly Asn Ile Ile Asp 
        275                 280                 285             


Leu Ser Met Asp Pro Pro Arg Asn Cys Ala Phe Val Thr Tyr Glu Lys 
    290                 295                 300                 


Met Glu Ser Ala Asp Gln Ala Val Ala Glu Leu Asn Gly Thr Gln Val 
305                 310                 315                 320 


Glu Ser Val Gln Leu Lys Val Asn Ile Ala Arg Lys Gln Pro Met Leu 
                325                 330                 335     


Asp Ala Ala Thr Gly Lys Ser Val Trp Gly Ser Leu Ala Val Gln Asn 
            340                 345                 350         


Ser Pro Lys Gly Cys His Arg Asp Lys Arg Thr Gln Ile Val Tyr Ser 
        355                 360                 365             


Asp Asp Val Tyr Lys Glu Asn Leu Val Asp Gly Phe 
    370                 375                 380 


<210>  1630
<211>  4187
<212>  DNA
<213>  Homosapiens

<400>  1630
cgtagcgccc gcagagcaac gcaaagagga agaacagaga aacggctatg agaaaaaggg     60

ccgaagagtg agaagcagag ggccttaccc gagggggcgg caaccggggg ccccacggtc    120

tccggccgcg cccgcgctgg ccgctgatag cgggctcaca acgatgacgt agcgaggagc    180

ggaaaacgcg gtaaccaagg cggccccagg cgcgcacttc cgcccggcct tccaccggtc    240

caggtctgcc cctccgcagc gatagttcac gctctcggcg gggctgtacc ggaagttgcc    300

tctacttccg cccgttccgg ggcggggctt acttcgcagc gactacttgc cgcacttccg    360

ggctgccagg cagctgctgt ggctccagga tgatggagac agagcgactt gtgctacccc    420

ctccagatcc cctggaccta ccccttcggg ccgtggagct cggatgcacg gggcactggg    480

agctgctgaa cttgcctgga gctccagaga gtagccttcc ccatggcctc cctccttgtg    540

ccccagatct gcagcaagaa gcagaacagt tgtttctgtc atccccagcc tggctgcctc    600

tgcatggtgt ggagcactca gcccgaaaat ggcagaggaa gacggatccc tggtctcttt    660

tggctgtcct gggagcccca gtcccatccg acctacaggc ccaaagacac ccaaccacag    720

gccagatact gggttacaaa gaggtcttgc tggagaacac aaatctctcg gctacaacct    780

ccttgtctct tcgccggcct ccagggccag cctcccagtc cttatgggga aatccaactc    840

agtatccctt ctggccaggg gggatggatg aacccaccat aacagatctg aacacacggg    900

aggaggctga ggaggagata gactttgaga aagatcttct tactattcca cctggtttca    960

agaaaggcat ggactttgca ccaaaagatt gtccaactcc agctcctgga ctactaagcc   1020

ttagctgtat gttggagcct ctggatttgg gtgggggtga cgaggatgag aatgaggcag   1080

tgggacagcc aggaggtccc agaggggaca ctgtttcagc ctctccctgc agtgctcccc   1140

tggcccgagc aagcagcttg gaagacctag tgttgaagga agcgtccaca gctgtatcca   1200

ccccagaggc cccagagcct ccatctcagg agcagtgggc catccctgtg gacgccacct   1260

cccctgttgg tgatttctat cgcctcattc cccagccagc cttccagtgg gcatttgagc   1320

cagatgtgtt tcagaaacag gccatcctgc acttggaacg gcatgactct gtctttgtcg   1380

cagctcacac atctgcagga aaaacagttg tggctgaata tgccattgcc ctggcccaga   1440

aacacatgac acgcaccatc tacacttcgc ccatcaaggc cctgagcaac cagaagttcc   1500

gggacttccg aaacacattc ggggatgtgg ggctgctcac cggggatgta cagctgcatc   1560

cggaggcctc ctgcctcatc atgaccacag agatccttcg ctccatgctg tacagtggct   1620

cagatgttat tcgggacctg gagtgggtca tctttgatga ggttcactat atcaacgatg   1680

tcgagcgtgg ggtcgtgtgg gaggaggtgc ttatcatgct acctgaccac gtttctatca   1740

tccttctgag tgccaccgtc cccaacgccc ttgagtttgc tgactggatt gggcggctga   1800

agcgtcgtca gatctatgtg attagcactg taacccgccc cgtgcccctg gagcactatc   1860

ttttcacagg gaacagctcc aagacccagg gggagctctt tttgttgctg gactcccgag   1920

gagccttcca tacaaaaggg tactatgcag ctgtggaggc caagaaggag agaatgagca   1980

aacacgccca gacctttggg gccaagcagc ccacacatca ggggggccct gcacaggacc   2040

gcggagtgta cctgtccctc ctggcctccc tccgcacacg tgcccagttg cccgtggtgg   2100

tgttcacctt ctcccggggc cgctgtgatg agcaggcctc aggcctcacc tcccttgacc   2160

tcaccaccag ttcggagaag agcgagatcc acctcttcct gcagcgctgc cttgctcgcc   2220

tccgtggctc tgaccgccag ctgccccagg tcctgcacat gtcagagctc ctgaatcgcg   2280

gcctgggtgt gcaccatagc ggcatcctgc ccatcctcaa ggagatcgtg gagatgctct   2340

tcagccgtgg cctggtcaag gtcttgtttg ccacagagac ctttgccatg ggagtaaaca   2400

tgcctgctcg tacagtagtg tttgactcca tgcgcaaaca cgatggctcc accttccggg   2460

acctgctccc tggggagtat gtgcagatgg caggccgggc agggcggagg ggcctggacc   2520

ccacaggcac cgttatcctg ctctgcaagg gccgagtgcc cgagatggca gacctgcacc   2580

gcatgatgat ggggaagccg tcccagctgc agtcccagtt ccgcctcacg tacactatga   2640

tcctcaactt gctgcgagtg gatgccctca gggtggagga catgatgaag aggagcttct   2700

ctgagtttcc ctcccgcaaa gacagcaagg cccatgaaca ggccctggct gaactgacca   2760

agaggctggg agctttggag gagcctgaca tgactggcca actggtcgac ctgcctgaat   2820

attacagctg gggggaggaa ctgacagaga cccagcacat gatccagcga cgcatcatgg   2880

agtctgtgaa cgggctgaag tctctctcag caggaagggt ggtggttgtg aagaatcagg   2940

agcatcacaa cgcattggga gtgatcctac aggtctcctc gaactccacc agcagagtat   3000

tcacaaccct ggtcttgtgt gataagccct tgtcccagga cccacaggac agggggccag   3060

ccactgcaga ggtgccctat ccagatgacc tcgtgggatt caagctgttc ctgcctgaag   3120

ggccttgtga ccacaccgtg gtcaagctcc agccaggaga tatggctgcc atcaccacca   3180

aggtgctccg ggtgaatggg gagaagatct tggaggactt cagcaagagg cagcagccaa   3240

aattcaagaa ggatcctccc cttgcagccg tgaccactgc tgtccaggaa ctgctgcgtc   3300

tggctcaggc ccacccagcc ggacctccca ccctcgaccc tgtcaatgac ctgcagctca   3360

aagatatgtc agttgtagag ggtgggctcc gggcccggaa gctggaggag ctgatccagg   3420

gggctcagtg tgtacacagc ccccgttttc ctgcccagta cctgaagctg cgggagcgaa   3480

tgcagataca gaaggagatg gagcggctgc gcttcctact gtcggatcag tcattgctgc   3540

tgcttcctga gtaccatcag cgagtagagg tgctccgaac cctgggttat gtggacgagg   3600

cgggcactgt gaagctggca gggcgggtgg cttgtgccat gagcagccat gagttgctcc   3660

tcactgagct catgtttgac aatgcactga gcaccctgcg gcctgaggag attgctgcct   3720

tgctctctgg cctggtctgc cagagccctg gggacgctgg ggatcagctc ccaaacaccc   3780

tcaagcaggg aatagaacgt gtccgggctg tggccaagcg gattggtgag gtccaggtgg   3840

cttgtggcct gaaccagacg gtggaggaat ttgtggggga gctgaatttt gggctggttg   3900

aggttgtata tgagtgggcc cggggcatgc ccttctccga gttggcaggg ctctcaggga   3960

cccctgaggg cctggtggtc cgctgcattc agcgcctggc tgagatgtgt cgctcactgc   4020

ggggggcagc ccgcctggta ggagagcctg tgctgggtgc caagatggag acagcggcta   4080

ccttgctacg gcgggacatc gtatttgcgg ccagcctcta cacccagtga atgccccatg   4140

taaaaacatg atgataaaac agcaaagcac aaaaaaaaaa aaaaaaa                 4187


<210>  1631
<211>  1246
<212>  PRT
<213>  Homosapiens

<400>  1631

Met Met Glu Thr Glu Arg Leu Val Leu Pro Pro Pro Asp Pro Leu Asp 
1               5                   10                  15      


Leu Pro Leu Arg Ala Val Glu Leu Gly Cys Thr Gly His Trp Glu Leu 
            20                  25                  30          


Leu Asn Leu Pro Gly Ala Pro Glu Ser Ser Leu Pro His Gly Leu Pro 
        35                  40                  45              


Pro Cys Ala Pro Asp Leu Gln Gln Glu Ala Glu Gln Leu Phe Leu Ser 
    50                  55                  60                  


Ser Pro Ala Trp Leu Pro Leu His Gly Val Glu His Ser Ala Arg Lys 
65                  70                  75                  80  


Trp Gln Arg Lys Thr Asp Pro Trp Ser Leu Leu Ala Val Leu Gly Ala 
                85                  90                  95      


Pro Val Pro Ser Asp Leu Gln Ala Gln Arg His Pro Thr Thr Gly Gln 
            100                 105                 110         


Ile Leu Gly Tyr Lys Glu Val Leu Leu Glu Asn Thr Asn Leu Ser Ala 
        115                 120                 125             


Thr Thr Ser Leu Ser Leu Arg Arg Pro Pro Gly Pro Ala Ser Gln Ser 
    130                 135                 140                 


Leu Trp Gly Asn Pro Thr Gln Tyr Pro Phe Trp Pro Gly Gly Met Asp 
145                 150                 155                 160 


Glu Pro Thr Ile Thr Asp Leu Asn Thr Arg Glu Glu Ala Glu Glu Glu 
                165                 170                 175     


Ile Asp Phe Glu Lys Asp Leu Leu Thr Ile Pro Pro Gly Phe Lys Lys 
            180                 185                 190         


Gly Met Asp Phe Ala Pro Lys Asp Cys Pro Thr Pro Ala Pro Gly Leu 
        195                 200                 205             


Leu Ser Leu Ser Cys Met Leu Glu Pro Leu Asp Leu Gly Gly Gly Asp 
    210                 215                 220                 


Glu Asp Glu Asn Glu Ala Val Gly Gln Pro Gly Gly Pro Arg Gly Asp 
225                 230                 235                 240 


Thr Val Ser Ala Ser Pro Cys Ser Ala Pro Leu Ala Arg Ala Ser Ser 
                245                 250                 255     


Leu Glu Asp Leu Val Leu Lys Glu Ala Ser Thr Ala Val Ser Thr Pro 
            260                 265                 270         


Glu Ala Pro Glu Pro Pro Ser Gln Glu Gln Trp Ala Ile Pro Val Asp 
        275                 280                 285             


Ala Thr Ser Pro Val Gly Asp Phe Tyr Arg Leu Ile Pro Gln Pro Ala 
    290                 295                 300                 


Phe Gln Trp Ala Phe Glu Pro Asp Val Phe Gln Lys Gln Ala Ile Leu 
305                 310                 315                 320 


His Leu Glu Arg His Asp Ser Val Phe Val Ala Ala His Thr Ser Ala 
                325                 330                 335     


Gly Lys Thr Val Val Ala Glu Tyr Ala Ile Ala Leu Ala Gln Lys His 
            340                 345                 350         


Met Thr Arg Thr Ile Tyr Thr Ser Pro Ile Lys Ala Leu Ser Asn Gln 
        355                 360                 365             


Lys Phe Arg Asp Phe Arg Asn Thr Phe Gly Asp Val Gly Leu Leu Thr 
    370                 375                 380                 


Gly Asp Val Gln Leu His Pro Glu Ala Ser Cys Leu Ile Met Thr Thr 
385                 390                 395                 400 


Glu Ile Leu Arg Ser Met Leu Tyr Ser Gly Ser Asp Val Ile Arg Asp 
                405                 410                 415     


Leu Glu Trp Val Ile Phe Asp Glu Val His Tyr Ile Asn Asp Val Glu 
            420                 425                 430         


Arg Gly Val Val Trp Glu Glu Val Leu Ile Met Leu Pro Asp His Val 
        435                 440                 445             


Ser Ile Ile Leu Leu Ser Ala Thr Val Pro Asn Ala Leu Glu Phe Ala 
    450                 455                 460                 


Asp Trp Ile Gly Arg Leu Lys Arg Arg Gln Ile Tyr Val Ile Ser Thr 
465                 470                 475                 480 


Val Thr Arg Pro Val Pro Leu Glu His Tyr Leu Phe Thr Gly Asn Ser 
                485                 490                 495     


Ser Lys Thr Gln Gly Glu Leu Phe Leu Leu Leu Asp Ser Arg Gly Ala 
            500                 505                 510         


Phe His Thr Lys Gly Tyr Tyr Ala Ala Val Glu Ala Lys Lys Glu Arg 
        515                 520                 525             


Met Ser Lys His Ala Gln Thr Phe Gly Ala Lys Gln Pro Thr His Gln 
    530                 535                 540                 


Gly Gly Pro Ala Gln Asp Arg Gly Val Tyr Leu Ser Leu Leu Ala Ser 
545                 550                 555                 560 


Leu Arg Thr Arg Ala Gln Leu Pro Val Val Val Phe Thr Phe Ser Arg 
                565                 570                 575     


Gly Arg Cys Asp Glu Gln Ala Ser Gly Leu Thr Ser Leu Asp Leu Thr 
            580                 585                 590         


Thr Ser Ser Glu Lys Ser Glu Ile His Leu Phe Leu Gln Arg Cys Leu 
        595                 600                 605             


Ala Arg Leu Arg Gly Ser Asp Arg Gln Leu Pro Gln Val Leu His Met 
    610                 615                 620                 


Ser Glu Leu Leu Asn Arg Gly Leu Gly Val His His Ser Gly Ile Leu 
625                 630                 635                 640 


Pro Ile Leu Lys Glu Ile Val Glu Met Leu Phe Ser Arg Gly Leu Val 
                645                 650                 655     


Lys Val Leu Phe Ala Thr Glu Thr Phe Ala Met Gly Val Asn Met Pro 
            660                 665                 670         


Ala Arg Thr Val Val Phe Asp Ser Met Arg Lys His Asp Gly Ser Thr 
        675                 680                 685             


Phe Arg Asp Leu Leu Pro Gly Glu Tyr Val Gln Met Ala Gly Arg Ala 
    690                 695                 700                 


Gly Arg Arg Gly Leu Asp Pro Thr Gly Thr Val Ile Leu Leu Cys Lys 
705                 710                 715                 720 


Gly Arg Val Pro Glu Met Ala Asp Leu His Arg Met Met Met Gly Lys 
                725                 730                 735     


Pro Ser Gln Leu Gln Ser Gln Phe Arg Leu Thr Tyr Thr Met Ile Leu 
            740                 745                 750         


Asn Leu Leu Arg Val Asp Ala Leu Arg Val Glu Asp Met Met Lys Arg 
        755                 760                 765             


Ser Phe Ser Glu Phe Pro Ser Arg Lys Asp Ser Lys Ala His Glu Gln 
    770                 775                 780                 


Ala Leu Ala Glu Leu Thr Lys Arg Leu Gly Ala Leu Glu Glu Pro Asp 
785                 790                 795                 800 


Met Thr Gly Gln Leu Val Asp Leu Pro Glu Tyr Tyr Ser Trp Gly Glu 
                805                 810                 815     


Glu Leu Thr Glu Thr Gln His Met Ile Gln Arg Arg Ile Met Glu Ser 
            820                 825                 830         


Val Asn Gly Leu Lys Ser Leu Ser Ala Gly Arg Val Val Val Val Lys 
        835                 840                 845             


Asn Gln Glu His His Asn Ala Leu Gly Val Ile Leu Gln Val Ser Ser 
    850                 855                 860                 


Asn Ser Thr Ser Arg Val Phe Thr Thr Leu Val Leu Cys Asp Lys Pro 
865                 870                 875                 880 


Leu Ser Gln Asp Pro Gln Asp Arg Gly Pro Ala Thr Ala Glu Val Pro 
                885                 890                 895     


Tyr Pro Asp Asp Leu Val Gly Phe Lys Leu Phe Leu Pro Glu Gly Pro 
            900                 905                 910         


Cys Asp His Thr Val Val Lys Leu Gln Pro Gly Asp Met Ala Ala Ile 
        915                 920                 925             


Thr Thr Lys Val Leu Arg Val Asn Gly Glu Lys Ile Leu Glu Asp Phe 
    930                 935                 940                 


Ser Lys Arg Gln Gln Pro Lys Phe Lys Lys Asp Pro Pro Leu Ala Ala 
945                 950                 955                 960 


Val Thr Thr Ala Val Gln Glu Leu Leu Arg Leu Ala Gln Ala His Pro 
                965                 970                 975     


Ala Gly Pro Pro Thr Leu Asp Pro Val Asn Asp Leu Gln Leu Lys Asp 
            980                 985                 990         


Met Ser Val Val Glu Gly Gly Leu  Arg Ala Arg Lys Leu  Glu Glu Leu 
        995                 1000                 1005             


Ile Gln  Gly Ala Gln Cys Val  His Ser Pro Arg Phe  Pro Ala Gln 
    1010                 1015                 1020             


Tyr Leu  Lys Leu Arg Glu Arg  Met Gln Ile Gln Lys  Glu Met Glu 
    1025                 1030                 1035             


Arg Leu  Arg Phe Leu Leu Ser  Asp Gln Ser Leu Leu  Leu Leu Pro 
    1040                 1045                 1050             


Glu Tyr  His Gln Arg Val Glu  Val Leu Arg Thr Leu  Gly Tyr Val 
    1055                 1060                 1065             


Asp Glu  Ala Gly Thr Val Lys  Leu Ala Gly Arg Val  Ala Cys Ala 
    1070                 1075                 1080             


Met Ser  Ser His Glu Leu Leu  Leu Thr Glu Leu Met  Phe Asp Asn 
    1085                 1090                 1095             


Ala Leu  Ser Thr Leu Arg Pro  Glu Glu Ile Ala Ala  Leu Leu Ser 
    1100                 1105                 1110             


Gly Leu  Val Cys Gln Ser Pro  Gly Asp Ala Gly Asp  Gln Leu Pro 
    1115                 1120                 1125             


Asn Thr  Leu Lys Gln Gly Ile  Glu Arg Val Arg Ala  Val Ala Lys 
    1130                 1135                 1140             


Arg Ile  Gly Glu Val Gln Val  Ala Cys Gly Leu Asn  Gln Thr Val 
    1145                 1150                 1155             


Glu Glu  Phe Val Gly Glu Leu  Asn Phe Gly Leu Val  Glu Val Val 
    1160                 1165                 1170             


Tyr Glu  Trp Ala Arg Gly Met  Pro Phe Ser Glu Leu  Ala Gly Leu 
    1175                 1180                 1185             


Ser Gly  Thr Pro Glu Gly Leu  Val Val Arg Cys Ile  Gln Arg Leu 
    1190                 1195                 1200             


Ala Glu  Met Cys Arg Ser Leu  Arg Gly Ala Ala Arg  Leu Val Gly 
    1205                 1210                 1215             


Glu Pro  Val Leu Gly Ala Lys  Met Glu Thr Ala Ala  Thr Leu Leu 
    1220                 1225                 1230             


Arg Arg  Asp Ile Val Phe Ala  Ala Ser Leu Tyr Thr  Gln 
    1235                 1240                 1245     


<210>  1632
<211>  1590
<212>  DNA
<213>  Homosapiens

<400>  1632
gcccgtcagt gctgggaggg gcggtggcga cgcacatacc agcatcacct ccgccaggcc     60

gggccccacg ccggccgcgg attggctccc tccaagggca cgcacgcccg gggactcgtt    120

ggcggcgtgg aggggcgccg gtggccacgt tggtgtcaac ctccttcgtg aagctcacac    180

ctcccccgcc ccgggagggg tttgcccgcc actgtcgctg aatgattgca tcatcgaaag    240

cagaaaacca cttttgcatc cttcggcctc tggcgtgcct gccatgacgt catagctctg    300

cggaggtgga agttggggag ctttgaggac ctcatggatc ccagggggac caagagagga    360

gctgagaaga cagaggtagc tgagcctcgg aacaaactac ctcgtccagc accttctctg    420

cccacagacc ctgccctcta ctctgggccc tttcctttct accggcgccc ttcggaactg    480

ggctgcttct ccctggatgc tcaacgccag taccatggag atgcccgagc cctgcgctac    540

tatagcccac cccccactaa cggtccaggc cccaactttg acctcagaga cggatacccg    600

gatcgatacc agccccggga cgaggaggtc caggaaaggc tggaccacct gctgtgctgg    660

ctcctggaac accgaggccg gttggagggg ggtccaggct ggctggcaga ggccatagtg    720

acgtggcggg ggcacctgac aaaactgctg acgacaccgt atgagcggca ggagggctgg    780

cagctggcag cctcccggtt ccagggaaca ctatacctga gtgaagtgga gacaccgaac    840

gctcgggccc agaggcttgc tcggccaccg ctcctccggg agcttatgta catgggatac    900

aaatttgagc agtacatgtg tgcagacaaa cctggaagct ccccagaccc ctctggggag    960

gttaacacca acgtggcctt ctgctctgtg ctacgcagcc gcctgggaag ccaccctctg   1020

ctcttctcag gggaggtaga ctgcacagac ccccaagccc catccacaca gcccccaacc   1080

tgctatgtgg agctcaagac ctccaaggag atgcacagcc ctggccaatg gaggagtttc   1140

tacagacaca agctcctgaa atggtgggct cagtcattcc tcccaggggt cccgaatgtt   1200

gttgctggct tccgtaaccc agacggtttt gtctcttccc tcaagacctt tcctaccatg   1260

aagatgtttg aatatgtcag gaatgaccgt gacggctgga atccctctgt gtgcatgaac   1320

ttctgtgccg ccttccttag ctttgcccag agcacggttg tccaggatga ccccaggctc   1380

gttcatctct tctcttggga gcctggcggc ccagtcaccg tgtctgtaca ccaagatgca   1440

ccttacgcct tcctgcccat atggtatgtg gaagctatga ctcaggacct cccatcaccc   1500

cccaagactc cctctcccaa atagtaatgc tttagaggga ggcagtcata tctctgtgtg   1560

cagataataa aagcatattt ctaagaggtt                                    1590


<210>  1633
<211>  396
<212>  PRT
<213>  Homosapiens

<400>  1633

Met Asp Pro Arg Gly Thr Lys Arg Gly Ala Glu Lys Thr Glu Val Ala 
1               5                   10                  15      


Glu Pro Arg Asn Lys Leu Pro Arg Pro Ala Pro Ser Leu Pro Thr Asp 
            20                  25                  30          


Pro Ala Leu Tyr Ser Gly Pro Phe Pro Phe Tyr Arg Arg Pro Ser Glu 
        35                  40                  45              


Leu Gly Cys Phe Ser Leu Asp Ala Gln Arg Gln Tyr His Gly Asp Ala 
    50                  55                  60                  


Arg Ala Leu Arg Tyr Tyr Ser Pro Pro Pro Thr Asn Gly Pro Gly Pro 
65                  70                  75                  80  


Asn Phe Asp Leu Arg Asp Gly Tyr Pro Asp Arg Tyr Gln Pro Arg Asp 
                85                  90                  95      


Glu Glu Val Gln Glu Arg Leu Asp His Leu Leu Cys Trp Leu Leu Glu 
            100                 105                 110         


His Arg Gly Arg Leu Glu Gly Gly Pro Gly Trp Leu Ala Glu Ala Ile 
        115                 120                 125             


Val Thr Trp Arg Gly His Leu Thr Lys Leu Leu Thr Thr Pro Tyr Glu 
    130                 135                 140                 


Arg Gln Glu Gly Trp Gln Leu Ala Ala Ser Arg Phe Gln Gly Thr Leu 
145                 150                 155                 160 


Tyr Leu Ser Glu Val Glu Thr Pro Asn Ala Arg Ala Gln Arg Leu Ala 
                165                 170                 175     


Arg Pro Pro Leu Leu Arg Glu Leu Met Tyr Met Gly Tyr Lys Phe Glu 
            180                 185                 190         


Gln Tyr Met Cys Ala Asp Lys Pro Gly Ser Ser Pro Asp Pro Ser Gly 
        195                 200                 205             


Glu Val Asn Thr Asn Val Ala Phe Cys Ser Val Leu Arg Ser Arg Leu 
    210                 215                 220                 


Gly Ser His Pro Leu Leu Phe Ser Gly Glu Val Asp Cys Thr Asp Pro 
225                 230                 235                 240 


Gln Ala Pro Ser Thr Gln Pro Pro Thr Cys Tyr Val Glu Leu Lys Thr 
                245                 250                 255     


Ser Lys Glu Met His Ser Pro Gly Gln Trp Arg Ser Phe Tyr Arg His 
            260                 265                 270         


Lys Leu Leu Lys Trp Trp Ala Gln Ser Phe Leu Pro Gly Val Pro Asn 
        275                 280                 285             


Val Val Ala Gly Phe Arg Asn Pro Asp Gly Phe Val Ser Ser Leu Lys 
    290                 295                 300                 


Thr Phe Pro Thr Met Lys Met Phe Glu Tyr Val Arg Asn Asp Arg Asp 
305                 310                 315                 320 


Gly Trp Asn Pro Ser Val Cys Met Asn Phe Cys Ala Ala Phe Leu Ser 
                325                 330                 335     


Phe Ala Gln Ser Thr Val Val Gln Asp Asp Pro Arg Leu Val His Leu 
            340                 345                 350         


Phe Ser Trp Glu Pro Gly Gly Pro Val Thr Val Ser Val His Gln Asp 
        355                 360                 365             


Ala Pro Tyr Ala Phe Leu Pro Ile Trp Tyr Val Glu Ala Met Thr Gln 
    370                 375                 380                 


Asp Leu Pro Ser Pro Pro Lys Thr Pro Ser Pro Lys 
385                 390                 395     


<210>  1634
<211>  1620
<212>  DNA
<213>  Homosapiens

<400>  1634
gtcctccaaa tgcagtgagg ttaggaagga cgtctgcgct cagatcaaga atccagttac     60

ctcaaagctc cccaacttcc acctccgcag agctatgacg tcatggcagg cacgccagag    120

gccgaaggat gcaaaagtgg ttttctgctt tcgatgatgc aatcattcag cgacagtggc    180

gggcaaaccc ctcccggggc gggggaggtg tgagcttcac gaaggaggtt gacaccaacg    240

tggccaccgg cgcccctcca cgccgccaac gagtccccgg gcgtgcgtgc ccttggaggg    300

agccaatccg cggccggcgt ggggcccggc ctggcggagg tgatgctgga gggacgcccg    360

gggagaccgt acgtcactgc tctgcgccgg aagaccctat tttcaggttc tcttccctcc    420

attcctaccc cttccccggt accataaaat cccgggatat gagctggaag aggcatcacc    480

tgatcccgga gacctttgga gttaagaggc ggcggaagcg agggcctgtg gagtcggatc    540

ctcttcgggg tgagccaggg tcggcgcgcg cggctgtctc agaactcatg cagctgttcc    600

cgcgaggcct gtttgaggac gcgctgccgc ccatcgtgct gaggagccag gtgtacagcc    660

ttgtgcctga caggaccgtg gccgaccggc agctgaagga gcttcaagag cagggggaga    720

tcagaatcgt ccagctgggc ttcgacttgg atgcccatgg aattatcttc actgaggact    780

acaggaccag agtcctcaag gcctgtgatg gccgaccgta tgctggggca gtgcagaaat    840

ttctagcttc agtacttcca gcctgtgggg accttagttt ccagcaggac caaatgacac    900

agacctttgg cttcagggac tcagaaatca cgcatctggt gaatgctgga gtcctcaccg    960

tccgagatgc tgggagctgg tggctagctg tgcctggagc tgggagattc atcaagtact   1020

ttgttaaagg gcgccaggct gtccttagca tggtccggaa ggcaaagtac cgggaactgc   1080

tcctatcaga gctcctgggc cggcgggcgc ctgtcgtggt gcggcttggc ctcacctacc   1140

atgtgcacga cctcattggg gcccagctag tggactgcat ctctaccact tcaggaaccc   1200

tcctccgcct gccagagaca tgaagattct gctcatcatt gctcagctcc tcagagtggg   1260

ccgggagggg actagaagag ctgcatgatg gtggctgaga cagggtcacc ttgggaaggc   1320

ttgggagcca ggatgagtgt cgggctctcg tgtgtgcaaa aggtcagatg tgactgctgc   1380

tgtttgcctg gtttctgacc cagtggtggg gtttgagcaa tgcttctctg cccttccatg   1440

gaaagtggaa ccagaaatgg tgccaaggct gtggctgttc cctttcgtgt aaaatggtgc   1500

tgttattact ctgtcttgaa ataggaaggt gggatttctg gggaggctgg tgaaggaggg   1560

cagggttctt ttctctacgt gtcatgttaa aattgccaaa taaagtacct ctgcctgtga   1620


<210>  1635
<211>  364
<212>  PRT
<213>  Homosapiens

<400>  1635

Met Gln Lys Trp Phe Ser Ala Phe Asp Asp Ala Ile Ile Gln Arg Gln 
1               5                   10                  15      


Trp Arg Ala Asn Pro Ser Arg Gly Gly Gly Gly Val Ser Phe Thr Lys 
            20                  25                  30          


Glu Val Asp Thr Asn Val Ala Thr Gly Ala Pro Pro Arg Arg Gln Arg 
        35                  40                  45              


Val Pro Gly Arg Ala Cys Pro Trp Arg Glu Pro Ile Arg Gly Arg Arg 
    50                  55                  60                  


Gly Ala Arg Pro Gly Gly Gly Asp Ala Gly Gly Thr Pro Gly Glu Thr 
65                  70                  75                  80  


Val Arg His Cys Ser Ala Pro Glu Asp Pro Ile Phe Arg Phe Ser Ser 
                85                  90                  95      


Leu His Ser Tyr Pro Phe Pro Gly Thr Ile Lys Ser Arg Asp Met Ser 
            100                 105                 110         


Trp Lys Arg His His Leu Ile Pro Glu Thr Phe Gly Val Lys Arg Arg 
        115                 120                 125             


Arg Lys Arg Gly Pro Val Glu Ser Asp Pro Leu Arg Gly Glu Pro Gly 
    130                 135                 140                 


Ser Ala Arg Ala Ala Val Ser Glu Leu Met Gln Leu Phe Pro Arg Gly 
145                 150                 155                 160 


Leu Phe Glu Asp Ala Leu Pro Pro Ile Val Leu Arg Ser Gln Val Tyr 
                165                 170                 175     


Ser Leu Val Pro Asp Arg Thr Val Ala Asp Arg Gln Leu Lys Glu Leu 
            180                 185                 190         


Gln Glu Gln Gly Glu Ile Arg Ile Val Gln Leu Gly Phe Asp Leu Asp 
        195                 200                 205             


Ala His Gly Ile Ile Phe Thr Glu Asp Tyr Arg Thr Arg Val Leu Lys 
    210                 215                 220                 


Ala Cys Asp Gly Arg Pro Tyr Ala Gly Ala Val Gln Lys Phe Leu Ala 
225                 230                 235                 240 


Ser Val Leu Pro Ala Cys Gly Asp Leu Ser Phe Gln Gln Asp Gln Met 
                245                 250                 255     


Thr Gln Thr Phe Gly Phe Arg Asp Ser Glu Ile Thr His Leu Val Asn 
            260                 265                 270         


Ala Gly Val Leu Thr Val Arg Asp Ala Gly Ser Trp Trp Leu Ala Val 
        275                 280                 285             


Pro Gly Ala Gly Arg Phe Ile Lys Tyr Phe Val Lys Gly Arg Gln Ala 
    290                 295                 300                 


Val Leu Ser Met Val Arg Lys Ala Lys Tyr Arg Glu Leu Leu Leu Ser 
305                 310                 315                 320 


Glu Leu Leu Gly Arg Arg Ala Pro Val Val Val Arg Leu Gly Leu Thr 
                325                 330                 335     


Tyr His Val His Asp Leu Ile Gly Ala Gln Leu Val Asp Cys Ile Ser 
            340                 345                 350         


Thr Thr Ser Gly Thr Leu Leu Arg Leu Pro Glu Thr 
        355                 360                 


<210>  1636
<211>  1632
<212>  DNA
<213>  Homosapiens

<400>  1636
gtcctccaaa tgcagtgagg ttaggaagga cgtctgcgct cagatcaaga atccagttac     60

ctcaaagctc cccaacttcc acctccgcag agctatgacg tcatggcagg cacgccagag    120

gccgaaggat gcaaaagtgg ttttctgctt tcgatgatgc aatcattcag cgacagtggc    180

gggcaaaccc ctcccggggc gggggaggtg tgagcttcac gaaggaggtt gacaccaacg    240

tggccaccgg cgcccctcca cgccgccaac gagtccccgg gcgtgcgtgc ccttggaggg    300

agccaatccg cggccggcgt ggggcccggc ctggcggagg tgatgctgga gggacgcccg    360

gggagaccgt acgtcactgc tctgcgccgg aagaccctat tttcaggttc tcttccctcc    420

attcctaccc cttccccggt accataaaat cccgggatat gagctggaag aggcatcacc    480

tgatcccgga gacctttgga gttaagaggc ggcggaagcg agggcctgtg gagtcggatc    540

ctcttcgggg tgagccaggg tcggcgcgcg cggctgtctc agaactcatg cagctgttcc    600

cgcgaggcct gtttgaggac gcgctgccgc ccatcgtgct gaggagccag gtgtacagcc    660

ttgtgcctga caggaccgtg gccgaccggc agctgaagga gcttcaagag cagggggaga    720

tcagaatcgt ccagctgggc ttcgacttgg atgcccatgg aattatcttc actgaggact    780

acaggaccag agtatgtgac tgtgtcctca aggcctgtga tggccgaccg tatgctgggg    840

cagtgcagaa atttctagct tcagtacttc cagcctgtgg ggaccttagt ttccagcagg    900

accaaatgac acagaccttt ggcttcaggg actcagaaat cacgcatctg gtgaatgctg    960

gagtcctcac cgtccgagat gctgggagct ggtggctagc tgtgcctgga gctgggagat   1020

tcatcaagta ctttgttaaa gggcgccagg ctgtccttag catggtccgg aaggcaaagt   1080

accgggaact gctcctatca gagctcctgg gccggcgggc gcctgtcgtg gtgcggcttg   1140

gcctcaccta ccatgtgcac gacctcattg gggcccagct agtggactgc atctctacca   1200

cttcaggaac cctcctccgc ctgccagaga catgaagatt ctgctcatca ttgctcagct   1260

cctcagagtg ggccgggagg ggactagaag agctgcatga tggtggctga gacagggtca   1320

ccttgggaag gcttgggagc caggatgagt gtcgggctct cgtgtgtgca aaaggtcaga   1380

tgtgactgct gctgtttgcc tggtttctga cccagtggtg gggtttgagc aatgcttctc   1440

tgcccttcca tggaaagtgg aaccagaaat ggtgccaagg ctgtggctgt tccctttcgt   1500

gtaaaatggt gctgttatta ctctgtcttg aaataggaag gtgggatttc tggggaggct   1560

ggtgaaggag ggcagggttc ttttctctac gtgtcatgtt aaaattgcca aataaagtac   1620

ctctgcctgt ga                                                       1632


<210>  1637
<211>  368
<212>  PRT
<213>  Homosapiens

<400>  1637

Met Gln Lys Trp Phe Ser Ala Phe Asp Asp Ala Ile Ile Gln Arg Gln 
1               5                   10                  15      


Trp Arg Ala Asn Pro Ser Arg Gly Gly Gly Gly Val Ser Phe Thr Lys 
            20                  25                  30          


Glu Val Asp Thr Asn Val Ala Thr Gly Ala Pro Pro Arg Arg Gln Arg 
        35                  40                  45              


Val Pro Gly Arg Ala Cys Pro Trp Arg Glu Pro Ile Arg Gly Arg Arg 
    50                  55                  60                  


Gly Ala Arg Pro Gly Gly Gly Asp Ala Gly Gly Thr Pro Gly Glu Thr 
65                  70                  75                  80  


Val Arg His Cys Ser Ala Pro Glu Asp Pro Ile Phe Arg Phe Ser Ser 
                85                  90                  95      


Leu His Ser Tyr Pro Phe Pro Gly Thr Ile Lys Ser Arg Asp Met Ser 
            100                 105                 110         


Trp Lys Arg His His Leu Ile Pro Glu Thr Phe Gly Val Lys Arg Arg 
        115                 120                 125             


Arg Lys Arg Gly Pro Val Glu Ser Asp Pro Leu Arg Gly Glu Pro Gly 
    130                 135                 140                 


Ser Ala Arg Ala Ala Val Ser Glu Leu Met Gln Leu Phe Pro Arg Gly 
145                 150                 155                 160 


Leu Phe Glu Asp Ala Leu Pro Pro Ile Val Leu Arg Ser Gln Val Tyr 
                165                 170                 175     


Ser Leu Val Pro Asp Arg Thr Val Ala Asp Arg Gln Leu Lys Glu Leu 
            180                 185                 190         


Gln Glu Gln Gly Glu Ile Arg Ile Val Gln Leu Gly Phe Asp Leu Asp 
        195                 200                 205             


Ala His Gly Ile Ile Phe Thr Glu Asp Tyr Arg Thr Arg Val Cys Asp 
    210                 215                 220                 


Cys Val Leu Lys Ala Cys Asp Gly Arg Pro Tyr Ala Gly Ala Val Gln 
225                 230                 235                 240 


Lys Phe Leu Ala Ser Val Leu Pro Ala Cys Gly Asp Leu Ser Phe Gln 
                245                 250                 255     


Gln Asp Gln Met Thr Gln Thr Phe Gly Phe Arg Asp Ser Glu Ile Thr 
            260                 265                 270         


His Leu Val Asn Ala Gly Val Leu Thr Val Arg Asp Ala Gly Ser Trp 
        275                 280                 285             


Trp Leu Ala Val Pro Gly Ala Gly Arg Phe Ile Lys Tyr Phe Val Lys 
    290                 295                 300                 


Gly Arg Gln Ala Val Leu Ser Met Val Arg Lys Ala Lys Tyr Arg Glu 
305                 310                 315                 320 


Leu Leu Leu Ser Glu Leu Leu Gly Arg Arg Ala Pro Val Val Val Arg 
                325                 330                 335     


Leu Gly Leu Thr Tyr His Val His Asp Leu Ile Gly Ala Gln Leu Val 
            340                 345                 350         


Asp Cys Ile Ser Thr Thr Ser Gly Thr Leu Leu Arg Leu Pro Glu Thr 
        355                 360                 365             


<210>  1638
<211>  2023
<212>  DNA
<213>  Homosapiens


<220>
<221>  misc_feature
<222>  (1010)..(1010)
<223>  n is a, c, g, or t

<400>  1638
atgcgcctct cgtggagcgt ggcccagggc ccctttgatt ccttcgtggt ccagtatgag     60

gacacgaacg ggcagcccca ggccttgctc gtggacggcg accagagcaa gatcctcatc    120

tcaggcctgg agcccagcac cccctacagg ttcctcctct atggcctcca tgaagggaag    180

cgcctggggc ccctctcagc tgagggcacc acagggctgg ctcctgctgg tcagacctca    240

gaggagtcaa ggccccgcct gtcccagctg tctgtgactg acgtgaccac cagttcactg    300

aggctcaact gggaggcccc accgggggcc ttcgactcct tcctgctccg ctttggggtt    360

ccatcaccaa gcactctgga gccgcatccg cgtccactgc tgcagcgcga gctgatggtg    420

ccggggacgc ggcactcggc cgtgctccgg gacctgcgtt ccgggactct gtacagcctg    480

acactgtatg ggctgcgagg accccacaag gccgacagca tccagggaac cgcccgcacc    540

ctcagcccag ttctggagag cccccgtgac ctccaattca gtgaaatcag ggagacctca    600

gccaaggtca actggatgcc cccaccatcc cgggcggaca gcttcaaagt ctcctaccag    660

ctggcggacg gaggggagcc tcagagtgtg caggtggatg gccaggcccg gacccagaaa    720

ctccaggggc tgatcccagg cgctcgctat gaggtgaccg tggtctcggt ccgaggcttt    780

gaggagagtg agcctctcac aggcttcctc accacggttc ctgacggtcc cacacagttg    840

cgtgcactga acttgaccga gggattcgcc gtgctgcact ggaagccccc ccagaatcct    900

gtggacacct atgacgtcca ggtcacagcc cctggggccc cgcctctgca ggcggagacc    960

ccaggcagcg cggtggacta ccccctgcat gaccttgtcc tccacaccan ctacaccgcc   1020

acagtgcgtg gcctgcgggg ccccaacctc acttccccag ccagcatcac cttcaccaca   1080

agggctagag gcccctcggg acttggaggc caaggaagtg accccccgca ccgccctgct   1140

cacttggact gagcccccag tccggcccgc aggctacctg ctcagcttcc acacccctgg   1200

tggacagaac caggagatcc tgctcccagg agggatcaca tctcaccagc tccttggcct   1260

ctttccctcc acctcctaca atgcacggct ccaggccatg tggggccaga gcctcctgcc   1320

gcccgtgtcc acctctttca ccacgggtgg gctgcggatc cccttcccca gggactgcgg   1380

ggaggagatg cagaacggag ccggtgcctc caggaccagc accatcttcc tcaacggcaa   1440

ccgcgagcgg cccctgaacg tgttttgcga catggagact gatgggggcg gctggctggt   1500

gttccagcgc cgcatggatg gacagacaga cttctggagg gactgggagg actatgccca   1560

tggttttggg aacatctctg gagagttctg gctgggcaat gaggccctgc acagcctgac   1620

acaggcaggt gactactcca tgcgcgtgga cctgcgggct ggggacgagg ctgtgttcgc   1680

ccagtacgac tccttccacg tagactcggc tgcggagtac taccgcctcc acttggaggg   1740

ctaccacggc accgcagggg actccatgag ctaccacagc ggcagtgtct tctctgcccg   1800

tgatcgggac cccaacagct tgctcatctc ctgcgctgtc tcctaccgag gggcctggtg   1860

gtacaggaac tgccactacg ccaacctcaa cgggctctac gggagcacag tggaccatca   1920

gggagtgagc tggtaccact ggaagggctt cgagttctcg gtgcccttca cggaaatgaa   1980

gctgagacca agaaactttc gctccccagc ggggggaggc tga                     2023


<210>  1639
<211>  5426
<212>  DNA
<213>  Homosapiens

<400>  1639
agaaggtagc agacagacag acggatctaa cctctcttgg atcctccagc catgaggctg     60

ctctgggggc tgatctgggc atccagcttc ttcaccttat ctctgcagaa gcccaggttg    120

ctcttgttct ctccttctgt ggttcatctg ggggtccccc tatcggtggg ggtgcagctc    180

caggatgtgc cccgaggaca ggtagtgaaa ggatcagtgt tcctgagaaa cccatctcgt    240

aataatgtcc cctgctcccc aaaggtggac ttcaccctta gctcagaaag agacttcgca    300

ctcctcagtc tccaggtgcc cttgaaagat gcgaagagct gtggcctcca tcaactcctc    360

agaggccctg aggtccagct ggtggcccat tcgccatggc taaaggactc tctgtccaga    420

acgacaaaca tccagggtat caacctgctc ttctcctctc gccgggggca cctctttttg    480

cagacggacc agcccattta caaccctggc cagcgggttc ggtaccgggt ctttgctctg    540

gatcagaaga tgcgcccgag cactgacacc atcacagtca tggtggagaa ctctcacggc    600

ctccgcgtgc ggaagaagga ggtgtacatg ccctcgtcca tcttccagga tgactttgtg    660

atcccagaca tctcagagcc agggacctgg aagatctcag cccgattctc agatggcctg    720

gaatccaaca gcagcaccca gtttgaggtg aagaaatatg tccttcccaa ctttgaggtg    780

aagatcaccc ctggaaagcc ctacatcctg acggtgccag gccatcttga tgaaatgcag    840

ttagacatcc aggccaggta catctatggg aagccagtgc agggggtggc atatgtgcgc    900

tttgggctcc tagatgagga tggtaagaag actttctttc gggggctgga gagtcagacc    960

aagctggtga atggacagag ccacatttcc ctctcaaagg cagagttcca ggacgccctg   1020

gagaagctga atatgggcat tactgacctc caggggctgc gcctctacgt tgctgcagcc   1080

atcattgagt ctccaggtgg ggagatggag gaggcagagc tcacatcctg gtattttgtg   1140

tcatctccct tctccttgga tcttagcaag accaagcgac accttgtgcc tggggccccc   1200

ttcctgctgc aggccttggt ccgtgagatg tcaggctccc cagcttctgg cattcctgtc   1260

aaagtttctg ccacggtgtc ttctcctggg tctgttcctg aagtccagga cattcagcaa   1320

aacacagacg ggagcggcca agtcagcatt ccaataatta tccctcagac catctcagag   1380

ctgcagctct cagtatctgc aggctcccca catccagcga tagccaggct cactgtggca   1440

gccccacctt caggaggccc cgggtttctg tctattgagc ggccggattc tcgacctcct   1500

cgtgttgggg acactctgaa cctgaacttg cgagccgtgg gcagtggggc caccttttct   1560

cattactact acatgatcct atcccgaggg cagatcgtgt tcatgaatcg agagcccaag   1620

aggaccctga cctcggtctc ggtgtttgtg gaccatcacc tggcaccctc cttctacttt   1680

gtggccttct actaccatgg agaccaccca gtggccaact ccctgcgagt ggatgtccag   1740

gctggggcct gcgagggcaa gctggagctc agcgtggacg gtgccaagca gtaccggaac   1800

ggggagtccg tgaagctcca cttagaaacc gactccctag ccctggtggc gctgggagcc   1860

ttggacacag ctctgtatgc tgcaggcagc aagtcccaca agcccctcaa catgggcaag   1920

gtctttgaag ctatgaacag ctatgacctc ggctgtggtc ctgggggtgg ggacagtgcc   1980

cttcaggtgt tccaggcagc gggcctggcc ttttctgatg gagaccagtg gaccttatcc   2040

agaaagagac taagctgtcc caaggagaag acaacccgga aaaagagaaa cgtgaacttc   2100

caaaaggcga ttaatgagaa attgggtcag tatgcttccc cgacagccaa gcgctgctgc   2160

caggatgggg tgacacgtct gcccatgatg cgttcctgcg agcagcgggc agcccgcgtg   2220

cagcagccgg actgccggga gcccttcctg tcctgctgcc aatttgctga gagtctgcgc   2280

aagaagagca gggacaaggg ccaggcgggc ctccaacgag ccctggagat cctgcaggag   2340

gaggacctga ttgatgagga tgacattccc gtgcgcagct tcttcccaga gaactggctc   2400

tggagagtgg aaacagtgga ccgctttcaa atattgacac tgtggctccc cgactctctg   2460

accacgtggg agatccatgg cctgagcctg tccaaaacca aaggcctatg tgtggccacc   2520

ccagtccagc tccgggtgtt ccgcgagttc cacctgcacc tccgcctgcc catgtctgtc   2580

cgccgctttg agcagctgga gctgcggcct gtcctctata actacctgga taaaaacctg   2640

actgtgagcg tccacgtgtc cccagtggag gggctgtgcc tggctggggg cggagggctg   2700

gcccagcagg tgctggtgcc tgcgggctct gcccggcctg ttgccttctc tgtggtgccc   2760

acggcagcca ccgctgtgtc tctgaaggtg gtggctcgag ggtccttcga attccctgtg   2820

ggagatgcgg tgtccaaggt tctgcagatt gagaaggaag gggccatcca tagagaggag   2880

ctggtctatg aactcaaccc cttggaccac cgaggccgga ccttggaaat acctggcaac   2940

tctgatccca atatgatccc tgatggggac tttaacagct acgtcagggt tacagcctca   3000

gatccattgg acactttagg ctctgagggg gccttgtcac caggaggcgt ggcctccctc   3060

ttgaggcttc ctcgaggctg tggggagcaa accatgatct acttggctcc gacactggct   3120

gcttcccgct acctggacaa gacagagcag tggagcacac tgcctcccga gaccaaggac   3180

cacgccgtgg atctgatcca gaaaggctac atgcggatcc agcagtttcg gaaggcggat   3240

ggttcctatg cggcttggtt gtcacggggc agcagcacct ggctcacagc ctttgtgttg   3300

aaggtcctga gtttggccca ggagcaggta ggaggctcgc ctgagaaact gcaggagaca   3360

tctaactggc ttctgtccca gcagcaggct gacggctcgt tccaggacct ctctccagtg   3420

atacatagga gcatgcaggg gggtttggtg ggcaatgatg agactgtggc actcacagcc   3480

tttgtgacca tcgcccttca tcatgggctg gccgtcttcc aggatgaggg tgcagagcca   3540

ttgaagcaga gagtggaagc ctccatctca aaggcaagct catttttggg ggagaaagca   3600

agtgctgggc tcctgggtgc ccacgcagct gccatcacgg cctatgccct gacactgacc   3660

aaggcccctg cggacctgcg gggtgttgcc cacaacaacc tcatggcaat ggcccaggag   3720

actggagata acctgtactg gggctcagtc actggttctc agagcaatgc cgtgtcgccc   3780

accccggctc ctcgcaaccc atccgacccc atgccccagg ccccagccct gtggattgaa   3840

accacagcct acgccctgct gcacctcctg cttcacgagg gcaaagcaga gatggcagac   3900

caggctgcgg cctggctcac ccgtcagggc agcttccaag ggggattccg cagtacccaa   3960

gacacggtga ttgccctgga tgccctgtct gcctactgga ttgcctccca caccactgag   4020

gagaggggtc tcaatgtgac tctcagctcc acaggccgga atgggttcaa gtcccacgcg   4080

ctgcagctga acaaccgcca gattcgcggc ctggaggagg agctgcagtt ttccttgggc   4140

agcaagatca atgtgaaggt gggaggaaac agcaaaggaa ccctgaaggt ccttcgtacc   4200

tacaatgtcc tggacatgaa gaacacgacc tgccaggacc tacagataga agtgacagtc   4260

aaaggccacg tcgagtacac gatggaagca aacgaggact atgaggacta tgagtacgat   4320

gagcttccag ccaaggatga cccagatgcc cctctgcagc ccgtgacacc cctgcagctg   4380

tttgagggtc ggaggaaccg ccgcaggagg gaggcgccca aggtggtgga ggagcaggag   4440

tccagggtgc actacaccgt gtgcatctgg cggaacggca aggtggggct gtctggcatg   4500

gccatcgcgg acgtcaccct cctgagtgga ttccacgccc tgcgtgctga cctggagaag   4560

ctgacctccc tctctgaccg ttacgtgagt cactttgaga ccgaggggcc ccacgtcctg   4620

ctgtattttg actcggtccc cacctcccgg gagtgcgtgg gctttgaggc tgtgcaggaa   4680

gtgccggtgg ggctggtgca gccggccagc gcaaccctgt acgactacta caaccccgag   4740

cgcagatgtt ctgtgtttta cggggcacca agtaagagca gactcttggc caccttgtgt   4800

tctgctgaag tctgccagtg tgctgagggg aagtgccctc gccagcgtcg cgccctggag   4860

cggggtctgc aggacgagga tggctacagg atgaagtttg cctgctacta cccccgtgtg   4920

gagtacggct tccaggttaa ggttctccga gaagacagca gagctgcttt ccgcctcttt   4980

gagaccaaga tcacccaagt cctgcacttc accaaggatg tcaaggccgc tgctaatcag   5040

atgcgcaact tcctggttcg agcctcctgc cgccttcgct tggaacctgg gaaagaatat   5100

ttgatcatgg gtctggatgg ggccacctat gacctcgagg gacaccccca gtacctgctg   5160

gactcgaata gctggatcga ggagatgccc tctgaacgcc tgtgccggag cacccgccag   5220

cgggcagcct gtgcccagct caacgacttc ctccaggagt atggcactca ggggtgccag   5280

gtgtgagggc tgccctccca cctccgctgg gaggaacctg aacctgggaa ccatgaagct   5340

ggaagcactg ctgtgtccgc tttcatgaac acagcctggg accagggcat attaaaggct   5400

tttggcagca aagtgtcagt gttggc                                        5426


<210>  1640
<211>  1744
<212>  PRT
<213>  Homosapiens

<400>  1640

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Thr Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Gly Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Leu  Ser Pro Val Ile His  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Ser Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Ala Asp Leu Arg  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ala Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210>  1641
<211>  2114
<212>  DNA
<213>  Homosapiens

<400>  1641
tgggagggta cctgaaggtg gggtcaaggg aggccccaaa acagtctaca cagcaggagg     60

gatggctggg gctcttgagc tataagtggc acctcagggc cctgacgggc gtctcgccat    120

gctgctcctg ggcctgctgc tgctgctgcc cctgctggct ggcgcccgcc tgctgtggaa    180

ctggtggaag ctccggagcc tccacctccc gcctcttgcc ccgggcttct tgcacctgct    240

gcagcccgac ctccccatct atctgcttgg cctgactcag aaattcgggc ccatctacag    300

gctccacctt gggctgcaag atgtggtggt gctgaactcc aagaggacca ttgaggaagc    360

catggtcaaa aagtgggcag actttgctgg cagacctgag ccacttacct acaagctggt    420

gtctaggaac tacccggacc tgtccttggg agactactcc ctgctctgga aagcccacaa    480

gaagctcacc cgctcagccc tgctgctggg catccgtgac tccatggagc cagtggtgga    540

gcagctgacc caggagttct gtgagcgcat gagagcccag cccggcaccc ctgtggccat    600

tgaggaggaa ttctctctcc tcacctgcag catcatctgt tacctcacct tcggagacaa    660

gatcaaggac gacaacttaa tgcctgccta ttacaaatgt atccaggagg tgttaaaaac    720

ctggagccac tggtccatcc aaattgtgga cgtgattccc tttctcaggt tcttccccaa    780

tccaggtctc cggaggctga agcaggccat agagaagagg gatcacatcg tggagatgca    840

gctgaggcag cacaaggaga gcctcgtggc aggccagtgg agggacatga tggactacat    900

gctccaaggg gtggcgcagc cgagcatgga agagggctct ggacagctcc tggaagggca    960

cgtgcacatg gctgcagtgg acctcctgat cggtggcact gagaccacag caaacaccct   1020

ctcctgggcc gtggtttttt tgcttcacca ccctgagatt cagcagcgac tgcaggagga   1080

gctagaccac gaactgggcc ctggtgcctc cagctcccgg gtcccctaca aggaccgtgc   1140

acggctgccc ttgctcaatg ccaccatcgc cgaggtgctg cgcctgcggc ccgttgtgcc   1200

cttagccttg ccccaccgca ccacacggcc cagcagcatc tccggctacg acatccctga   1260

gggcacagtc atcattccga acctccaagg cgcccacctg gatgagacgg tctgggagag   1320

gccacatgag ttctggcctg atcgcttcct ggagccaggc aagaactcca gagctctggc   1380

cttcggctgc ggtgcccgcg tgtgcctggg cgagccgctg gcgcgcctgg agctcttcgt   1440

ggtgctgacc cgactgctgc aggccttcac gctgctgccc tccggggacg ccctgccctc   1500

cctgcagccc ctgccccact gcagtgtcat cctcaagatg cagcctttcc aagtgcggct   1560

gcagccccgg gggatggggg cccacagccc gggccagagc cagtgatggg gcaggaccga   1620

tgccagccgg gtacctcagt ttctccttta ttgctcccgt acgaacccct cccctccccc   1680

ctgtaaacac agtgctgcga gatcgctggc agagaaggct tcctccagcg gctgggtggt   1740

gaaggaccct ggctcttctc tcggggcgac ccctcagtgc tcggcagtca tactggggtg   1800

cgagagaggt gggcagcagc tcagcctccc cccgctgggg agcgaaagtt tcttggtctc   1860

agcttcattt ccgtgaaggg caccgagaac tcgaagccct tccagtggta ccagctcact   1920

ccctgggaaa ggggttgtca agagagagtc aaagccggat gtcccatctg ctcttcccgt   1980

tccccttaag gaggtagctc ccagcactca accaacctcc ccgcagagct cccttcctga   2040

ccctccgctg cagaggattg aggcttaatt ctgagctggc cctttccagc caataaatca   2100

actccagctc cctc                                                     2114


<210>  1642
<211>  495
<212>  PRT
<213>  Homosapiens

<400>  1642

Met Leu Leu Leu Gly Leu Leu Leu Leu Leu Pro Leu Leu Ala Gly Ala 
1               5                   10                  15      


Arg Leu Leu Trp Asn Trp Trp Lys Leu Arg Ser Leu His Leu Pro Pro 
            20                  25                  30          


Leu Ala Pro Gly Phe Leu His Leu Leu Gln Pro Asp Leu Pro Ile Tyr 
        35                  40                  45              


Leu Leu Gly Leu Thr Gln Lys Phe Gly Pro Ile Tyr Arg Leu His Leu 
    50                  55                  60                  


Gly Leu Gln Asp Val Val Val Leu Asn Ser Lys Arg Thr Ile Glu Glu 
65                  70                  75                  80  


Ala Met Val Lys Lys Trp Ala Asp Phe Ala Gly Arg Pro Glu Pro Leu 
                85                  90                  95      


Thr Tyr Lys Leu Val Ser Arg Asn Tyr Pro Asp Leu Ser Leu Gly Asp 
            100                 105                 110         


Tyr Ser Leu Leu Trp Lys Ala His Lys Lys Leu Thr Arg Ser Ala Leu 
        115                 120                 125             


Leu Leu Gly Ile Arg Asp Ser Met Glu Pro Val Val Glu Gln Leu Thr 
    130                 135                 140                 


Gln Glu Phe Cys Glu Arg Met Arg Ala Gln Pro Gly Thr Pro Val Ala 
145                 150                 155                 160 


Ile Glu Glu Glu Phe Ser Leu Leu Thr Cys Ser Ile Ile Cys Tyr Leu 
                165                 170                 175     


Thr Phe Gly Asp Lys Ile Lys Asp Asp Asn Leu Met Pro Ala Tyr Tyr 
            180                 185                 190         


Lys Cys Ile Gln Glu Val Leu Lys Thr Trp Ser His Trp Ser Ile Gln 
        195                 200                 205             


Ile Val Asp Val Ile Pro Phe Leu Arg Phe Phe Pro Asn Pro Gly Leu 
    210                 215                 220                 


Arg Arg Leu Lys Gln Ala Ile Glu Lys Arg Asp His Ile Val Glu Met 
225                 230                 235                 240 


Gln Leu Arg Gln His Lys Glu Ser Leu Val Ala Gly Gln Trp Arg Asp 
                245                 250                 255     


Met Met Asp Tyr Met Leu Gln Gly Val Ala Gln Pro Ser Met Glu Glu 
            260                 265                 270         


Gly Ser Gly Gln Leu Leu Glu Gly His Val His Met Ala Ala Val Asp 
        275                 280                 285             


Leu Leu Ile Gly Gly Thr Glu Thr Thr Ala Asn Thr Leu Ser Trp Ala 
    290                 295                 300                 


Val Val Phe Leu Leu His His Pro Glu Ile Gln Gln Arg Leu Gln Glu 
305                 310                 315                 320 


Glu Leu Asp His Glu Leu Gly Pro Gly Ala Ser Ser Ser Arg Val Pro 
                325                 330                 335     


Tyr Lys Asp Arg Ala Arg Leu Pro Leu Leu Asn Ala Thr Ile Ala Glu 
            340                 345                 350         


Val Leu Arg Leu Arg Pro Val Val Pro Leu Ala Leu Pro His Arg Thr 
        355                 360                 365             


Thr Arg Pro Ser Ser Ile Ser Gly Tyr Asp Ile Pro Glu Gly Thr Val 
    370                 375                 380                 


Ile Ile Pro Asn Leu Gln Gly Ala His Leu Asp Glu Thr Val Trp Glu 
385                 390                 395                 400 


Arg Pro His Glu Phe Trp Pro Asp Arg Phe Leu Glu Pro Gly Lys Asn 
                405                 410                 415     


Ser Arg Ala Leu Ala Phe Gly Cys Gly Ala Arg Val Cys Leu Gly Glu 
            420                 425                 430         


Pro Leu Ala Arg Leu Glu Leu Phe Val Val Leu Thr Arg Leu Leu Gln 
        435                 440                 445             


Ala Phe Thr Leu Leu Pro Ser Gly Asp Ala Leu Pro Ser Leu Gln Pro 
    450                 455                 460                 


Leu Pro His Cys Ser Val Ile Leu Lys Met Gln Pro Phe Gln Val Arg 
465                 470                 475                 480 


Leu Gln Pro Arg Gly Met Gly Ala His Ser Pro Gly Gln Ser Gln 
                485                 490                 495 


<210>  1643
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1643
ggtcctcccc ttctcctccc ctgctcgctg cagactccct cctcactgtc gctgccgaga     60

tccacagtcg gttgtggctc agcccctgtt gcaggggaca agtgagggag acttccctgt    120

cctgccctga gacgccgccc tcccggggtt ggggacagag caggtgcaga ggcactgcag    180

ctgctcggtt gcccagcctc ctgaatgatg ccagcccagt atgctctaac ctccagcctg    240

gttctcctgg tgctgctgag cacagccaga gcaggcccct tctcttcacg gtccaatgtg    300

acactgccag ccccccggcc ccctccccag ccagggggcc acacagtggg ggctggagtg    360

ggaagcccct cttctcagct ttacgagcac acagtggaag gaggggagaa gcaggtggta    420

ttcacccacc gcattaacct gcccccttcc actggctgtg gctgtccccc aggcaccgag    480

cccccagtcc ttgcttcaga ggtacaggcc ctgagggtcc gtctagagat cctggaggag    540

ttggtgaagg ggctcaagga acagtgcact gggggatgtt gtcctgcctc tgcccaagct    600

ggcacaggtc agacagatgt gcggaccctc tgcagtctcc atggtgtgtt tgatctgagc    660

cgctgcacct gttcctgtga gccaggctgg ggtgggccca cctgctcaga ccccacagat    720

gctgagatcc ctccctcttc cccaccctca gcctcggggt cctgcccaga tgactgcaat    780

gatcagggtc gctgtgtccg tggtcgttgc gtgtgctttc ccggctacac tggccccagc    840

tgtggctggc catcctgtcc cggggactgc caaggccgtg ggcgctgcgt gcagggcgtg    900

tgtgtgtgcc gggcaggctt ctcaggcccc gactgcagcc agcgctcctg ccctcgaggt    960

tgcagccaga ggggacgctg tgagggtggg cgctgcgtgt gtgacccagg ctacactggt   1020

gacgactgtg gcatgaggag ctgccctcgc ggttgcagtc agagggggcg ctgtgagaat   1080

gggcgctgcg tgtgtaaccc cggctacact ggcgaggact gtggggtgag gagctgccct   1140

cggggctgca gccagcgggg acgctgcaag gacgggcgct gcgtgtgtga ccccggctac   1200

actggcgagg actgtggtac gcggagctgc ccctgggact gtggcgaggg cgggcgctgc   1260

gtggacggcc gctgcgtgtg ctggcccggg tacacaggcg aggactgcag cacgcggaca   1320

tgtccgaggg actgccgggg ccgcgggcgc tgcgaggacg gcgaatgcat ttgcgacacg   1380

ggctacagcg gggacgactg cggcgtgcgc agctgccctg gcgactgcaa ccaaaggggc   1440

cgctgcgagg acggccgctg cgtgtgctgg ccggggtaca ctggaaccga ttgcggctcg   1500

cgcgcctgcc cacgcgactg tagaggtcgc gggcgctgcg agaacggcgt gtgtgtttgc   1560

aatgcgggct acagcggcga ggactgcggt gtgcgcagct gtcctgggga ctgtcgtggc   1620

cggggccgct gtgagagtgg ccgctgcatg tgttggccgg ggtacacagg ccgggactgc   1680

ggcacgcgcg cctgtcctgg cgactgtcgc gggcgcgggc gctgcgtgga tggccgctgc   1740

gtgtgcaacc cgggcttcac cggtgaggac tgtgggagcc gtcgctgtcc cggggactgc   1800

cgtgggcacg gcctttgcga ggatggcgtg tgcgtgtgtg acgcaggcta ctcaggggaa   1860

gactgcagca cgcgcagctg ccccgggggc tgccgaggcc gcggccagtg cctagatggg   1920

cggtgtgtgt gcgaggacgg ctactctggc gaggattgcg gtgtgaggca gtgcccgaat   1980

gactgcagcc agcacggcgt gtgccaggac ggtgtgtgca tctgttggga aggctacgtg   2040

agtgaggact gcagcatccg cacctgcccc tccaactgcc acgggagggg ccgctgtgag   2100

gaagggcgct gcctgtgcga cccaggctac accggcccta cctgtgccac ccgcatgtgc   2160

ccggctgact gccggggacg tgggcggtgt gtgcaaggag tgtgcctgtg ccacgtgggc   2220

tatggcggtg aggactgcgg gcaggaagag cctccagcca gcgcctgccc tggaggctgc   2280

gggccccggg aactgtgccg ggcaggccag tgtgtgtgtg tagagggctt ccgaggccct   2340

gactgtgcca tccagacatg cccaggggac tgccgtggcc gaggagagtg tcacgatggc   2400

agctgtgtct gcaaagatgg gtatgctggc gaagactgcg gagaagcacg ggttccaagc   2460

tctgcctcag cctatgacca gagaggactg gcccctggac aggagtacca ggtcactgtc   2520

cgagcccttc gagggaccag ctggggcctt cctgcctcca agaccatcac caccatgatc   2580

gatgggcccc aggacctccg agtggtggct gtgacaccga caacactgga gcttggctgg   2640

ctgcgtcccc aggctgaggt ggaccgattt gtggtgtcct acgtcagtgc cggcaaccag   2700

agggtgaggc tggaagtgcc ccctgaagca gacgggacgc tgctgactga cctgatgcca   2760

ggcgtagaat atgtggtgac tgtcacagcg gagcggggcc gggcagtcag ctacccagct   2820

tctgtcaggg ccaacacaga ggaaagggag gaggagtccc cgcccaggcc aagcctgtcc   2880

cagcccccac ggcggccttg gggcaacctg acggccgagc tgagccgttt ccgcggcacg   2940

gtgcaggacc tggagcgcca cctgcgggct cacggctacc cactgcgggc caaccagact   3000

tacacgtcgg tggcgcgcca catccatgaa tacttgcagc ggcaggtgct gggcagttcc   3060

gccgatggcg cgcttctcgt gtctctcgac gggctccgcg gccagttcga gcgcgtggtg   3120

ctgcgctggc ggcctcagcc gcctgcagag ggccccggcg gtgagctgac tgtgccgggc   3180

accacgcgca ccgtcagcct gcccgacctc aggcccggca ccacctacca cgtggaggtc   3240

cacggggtgc gggcggggca gacctccaag tcctacgcct tcatcaccac cacaggcccc   3300

tcgacgacgc aaggggccca ggctcctctc ctgcagcagc gcccccagga gctgggagag   3360

ttgagggtgc tgggcagaga tgagacaggg cgcctccgtg tggtctggac cgcccagcct   3420

gacacctttg cctacttcca actgcgcatg cgggtgcccg aggggccggg ggcacatgag   3480

gaagtgctgc caggggacgt ccgccaggct ctggtgcctc caccccctcc tggaaccccg   3540

tatgagctgt cacttcatgg ggtccctcct gggggcaagc cctctgaccc catcatctac   3600

caaggcatta tggacaagga tgaggagaag cctgggaagt cctcaggccc accacgcctg   3660

ggtgagctga cggtgacaga caggacctcc gactccttgc tcctgcgctg gacggtcccc   3720

gagggcgagt ttgactcctt cgtgatccag tacaaagaca gggacgggca gccccaggtg   3780

gtgcccgtgg aaggacccca gcgctcggcc gtcatcacct ccctggatcc tggccgcaag   3840

tacaaatttg tcctgtatgg gtttgttggc aagaagaggc atggtccgct ggtggctgaa   3900

gccaagatct tgcctcagag tgacccaagt ccagggactc caccccacct gggaaacctg   3960

tgggtgacag accctacccc agattcactg cacctctcct ggactgtccc tgagggccag   4020

tttgacacct tcatggtcca gtacagggac agggatggac ggccccaggt ggtacctgtg   4080

gaagggcccg agcgttcatt tgttgtctcc tcactggacc ctgaccacaa gtacagattc   4140

actctgtttg gaattgcgaa caagaagcgg tatggccccc tcacggccga tggcaccact   4200

gctccagaga ggaaagagga gcccccccgc cctgagttcc tggagcagcc cctcctgggg   4260

gaactgacag tgaccggcgt gaccccagac tccttgcgtc tctcatggac agtggcccag   4320

ggccccttcg actcattcat ggtccagtac aaggatgcac aggggcagcc ccaggcagtg   4380

cctgttgcgg gggatgagaa tgaggttact gtccccggcc tggatcccga ccggaagtat   4440

aagatgaacc tctacgggct tcgtggcagg cagcgtgtgg ggcccgagtc tgtggtggcc   4500

aagactgctc ctcaggagga tgtggacgag acccccagcc ccacagaact gggcacggag   4560

gccccggagt cccccgagga gccgctcctg ggggagctga cagtgacagg atcctcccct   4620

gattcgctga gcctcttctg gaccgtcccc cagggcagct tcgactcttt caccgtgcag   4680

tacaaggaca gggatgggcg gccccgggcg gtgcgtgttg ggggcaagga gagtgaggtc   4740

accgtgggag gcctagagcc cgggcacaag tacaagatgc acctgtacgg cctccacgag   4800

gggcagcgcg tgggcccggt gtccgccgtg ggcgtgacag ccccacaaca agaagagacc   4860

cctccagcca ctgagtcccc gctggagcca cgcctaggag agctgacagt gacagatgtg   4920

acccccaact ctgtgggcct ctcctggaca gtccccgagg gccagtttga ctccttcata   4980

gtccagtaca aggacaagga cgggcagccc caggtggtgc cggtggcggc agaccagcga   5040

gaggtcacag tctacaacct ggagcctgag agaaaatata agatgaacat gtatggacta   5100

catgatgggc aacgcatggg ccccctgtct gtggtcatcg tgacggcccc agccacagag   5160

gcctccaagc ctcccctgga gccacgccta ggggagctga cagtgacgga tataacccct   5220

gactctgtgg gcctctcatg gacagtccct gagggtgaat tcgactcctt tgtggttcag   5280

tacaaggaca gggacgggca gccccaggtg gtgcccgtgg ctgcagatca gcgggaggtc   5340

actatccctg acctggaacc ctcccgcaag tacaagttcc tgctctttgg gatccaggat   5400

gggaaacgac gcagcccagt ctctgtggag gcaaagacgg ttgcccgagg tgacgccagc   5460

ccaggggccc caccccgcct tggggagctg tgggtgacag accccacccc agactcactg   5520

cgcctctcct ggacggttcc tgagggccag ttcgactctt ttgtggtcca gttcaaggac   5580

aaagacgggc cccaggtggt gcccgtggag ggccatgagc gctctgtcac tgtcacccct   5640

ctggatgccg gccgcaagta cagattcctc ctctatggcc tcctgggcaa gaagcgccat   5700

ggccctctca ctgccgacgg caccacggaa gcccggagtg ctatggatga tactggaaca   5760

aagcgtcccc caaaaccccg tctgggggag gagctgcagg tgaccaccgt gacccagaac   5820

tccgtgggcc tctcctggac agtccctgag ggccagtttg actcctttgt ggtccagtac   5880

aaagacaggg acgggcagcc ccaggtggtg cccgtggagg gcagcctcag ggaggtcagc   5940

gtgccgggcc tggaccctgc ccacaggtac aagctgctgc tctacgggct gcaccacggc   6000

aagcgtgtgg gccccatctc ggccgtcgcc attactgccg gcagggaaga aacggaaact   6060

gagaccacgg ccccgacccc tccagcgcct gagccccacc tcggggagtt gacagtggag   6120

gaggccacgt cacacaccct gcatctctcc tggatggtga ctgagggaga atttgactcc   6180

ttcgaaatcc agtacacaga tagagacggg caactccaaa tggtccgcat aggaggtgac   6240

cggaatgaca tcaccctctc tggcctggaa tccgaccaca gatacctggt gaccctgtat   6300

ggtttcagtg atgggaagca tgtaggtcct gtccatgtcg aggccctgac agtcccggag   6360

gaggagaagc cttcagaacc tcccaccgca acccccgagc cccccatcaa gcctcgcctg   6420

ggggagctga ccgtgacaga tgccacccct gactccctca gcctgtcctg gacagttccc   6480

gagggacagt ttgaccactt cctggtccag tacaggaatg gagatgggca gcccaaggca   6540

gtgagggtgc cagggcacga ggaaggggtc accatctcgg gcctggagcc agaccataaa   6600

tacaagatga acctgtacgg cttccacggt ggccagcgca tgggccctgt gtctgtcgtc   6660

ggggtgacag aacccagcat ggaggccccg gagcccgctg aggagccgct cctgggggag   6720

ctaacagtga caggatcctc ccctgactcg ctgagcctct cctggaccgt cccccagggc   6780

cgcttcgact ccttcaccgt gcagtacaag gacagggacg ggcggcccca ggtggtgcgt   6840

gttgggggcg aggagagtga agtcaccgtg gggggcctgg agcctgggcg caagtacaag   6900

atgcacctgt acggcctcca cgaggggcgg cgcgtgggcc cagtgtctgc tgtgggcgtc   6960

acggcccccg aagaggagtc ccctgatgct cctcttgcaa agctgcgcct agggcagatg   7020

acagtgagag acatcacctc cgactccctc agcctctcct ggacagtccc cgagggccag   7080

tttgaccatt tcttggtcca gtttaagaat ggggacgggc agcccaaggc ggtgcgggtg   7140

ccgggacacg aggatggggt caccatctcg ggcctggagc cagaccacaa gtacaagatg   7200

aacctgtacg gcttccacgg tggccagcgc gtgggccccg tgtctgctgt tggtttaact   7260

gcctcgacag aacctcccac ccctgaaccc cccatcaagc ctcgcctgga ggagctgacc   7320

gtgacagatg cgacccctga ctccctcagc ctgtcctgga cggttcccga gggacagttt   7380

gaccacttcc tggtccagta caagaatggg gatgggcagc ccaaggcaac acgggtgcca   7440

ggacatgagg acagggtcac catctccggc ctggagccag acaacaagta caagatgaac   7500

ctgtacggct tccacggtgg ccagcgtgtg ggccccgtgt ctgccatcgg ggtgacagag   7560

gaagagaccc ccagccccac agaacccagc atggaggccc cggagccccc tgaggagccg   7620

ctcctggggg agctaacagt gacaggatcc tcccctgact cgctgagcct ctcctggacc   7680

gtcccccagg gccgcttcga ctccttcacc gtgcagtaca aggacaggga cgggcggccc   7740

caggtggtgc gtgttggggg cgaggagagc gaggtcaccg tggggggcct ggagcctggg   7800

cgcaaataca agatgcacct gtatggcctc cacgaggggc ggcgcgtggg cccggtgtcc   7860

accgtgggcg tgactgcccc acaagaggat gtggacgaga cccccagccc tacagaacca   7920

ggcacagagg ccccagggcc ccccgaggag cctctcctgg gggagctgac agtgacagga   7980

tcctcccctg actcgctgag cctttcctgg accgtccccc agggccgctt tgactccttc   8040

accgtgcagt acaaggacag ggacgggcgg ccccaggcgg tgcgtgttgg gggccaggag   8100

agcaaggtca ctgtgagggg cctggagcct gggcgcaagt acaagatgca cctgtacggc   8160

ctccacgagg ggcggcgcct gggcccggtg tc                                 8192


<210>  1644
<211>  4289
<212>  PRT
<213>  Homosapiens

<400>  1644

Met Met Pro Ala Gln Tyr Ala Leu Thr Ser Ser Leu Val Leu Leu Val 
1               5                   10                  15      


Leu Leu Ser Thr Ala Arg Ala Gly Pro Phe Ser Ser Arg Ser Asn Val 
            20                  25                  30          


Thr Leu Pro Ala Pro Arg Pro Pro Pro Gln Pro Gly Gly His Thr Val 
        35                  40                  45              


Gly Ala Gly Val Gly Ser Pro Ser Ser Gln Leu Tyr Glu His Thr Val 
    50                  55                  60                  


Glu Gly Gly Glu Lys Gln Val Val Phe Thr His Arg Ile Asn Leu Pro 
65                  70                  75                  80  


Pro Ser Thr Gly Cys Gly Cys Pro Pro Gly Thr Glu Pro Pro Val Leu 
                85                  90                  95      


Ala Ser Glu Val Gln Ala Leu Arg Val Arg Leu Glu Ile Leu Glu Glu 
            100                 105                 110         


Leu Val Lys Gly Leu Lys Glu Gln Cys Thr Gly Gly Cys Cys Pro Ala 
        115                 120                 125             


Ser Ala Gln Ala Gly Thr Gly Gln Thr Asp Val Arg Thr Leu Cys Ser 
    130                 135                 140                 


Leu His Gly Val Phe Asp Leu Ser Arg Cys Thr Cys Ser Cys Glu Pro 
145                 150                 155                 160 


Gly Trp Gly Gly Pro Thr Cys Ser Asp Pro Thr Asp Ala Glu Ile Pro 
                165                 170                 175     


Pro Ser Ser Pro Pro Ser Ala Ser Gly Ser Cys Pro Asp Asp Cys Asn 
            180                 185                 190         


Asp Gln Gly Arg Cys Val Arg Gly Arg Cys Val Cys Phe Pro Gly Tyr 
        195                 200                 205             


Thr Gly Pro Ser Cys Gly Trp Pro Ser Cys Pro Gly Asp Cys Gln Gly 
    210                 215                 220                 


Arg Gly Arg Cys Val Gln Gly Val Cys Val Cys Arg Ala Gly Phe Ser 
225                 230                 235                 240 


Gly Pro Asp Cys Ser Gln Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg 
                245                 250                 255     


Gly Arg Cys Glu Gly Gly Arg Cys Val Cys Asp Pro Gly Tyr Thr Gly 
            260                 265                 270         


Asp Asp Cys Gly Met Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg Gly 
        275                 280                 285             


Arg Cys Glu Asn Gly Arg Cys Val Cys Asn Pro Gly Tyr Thr Gly Glu 
    290                 295                 300                 


Asp Cys Gly Val Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg Gly Arg 
305                 310                 315                 320 


Cys Lys Asp Gly Arg Cys Val Cys Asp Pro Gly Tyr Thr Gly Glu Asp 
                325                 330                 335     


Cys Gly Thr Arg Ser Cys Pro Trp Asp Cys Gly Glu Gly Gly Arg Cys 
            340                 345                 350         


Val Asp Gly Arg Cys Val Cys Trp Pro Gly Tyr Thr Gly Glu Asp Cys 
        355                 360                 365             


Ser Thr Arg Thr Cys Pro Arg Asp Cys Arg Gly Arg Gly Arg Cys Glu 
    370                 375                 380                 


Asp Gly Glu Cys Ile Cys Asp Thr Gly Tyr Ser Gly Asp Asp Cys Gly 
385                 390                 395                 400 


Val Arg Ser Cys Pro Gly Asp Cys Asn Gln Arg Gly Arg Cys Glu Asp 
                405                 410                 415     


Gly Arg Cys Val Cys Trp Pro Gly Tyr Thr Gly Thr Asp Cys Gly Ser 
            420                 425                 430         


Arg Ala Cys Pro Arg Asp Cys Arg Gly Arg Gly Arg Cys Glu Asn Gly 
        435                 440                 445             


Val Cys Val Cys Asn Ala Gly Tyr Ser Gly Glu Asp Cys Gly Val Arg 
    450                 455                 460                 


Ser Cys Pro Gly Asp Cys Arg Gly Arg Gly Arg Cys Glu Ser Gly Arg 
465                 470                 475                 480 


Cys Met Cys Trp Pro Gly Tyr Thr Gly Arg Asp Cys Gly Thr Arg Ala 
                485                 490                 495     


Cys Pro Gly Asp Cys Arg Gly Arg Gly Arg Cys Val Asp Gly Arg Cys 
            500                 505                 510         


Val Cys Asn Pro Gly Phe Thr Gly Glu Asp Cys Gly Ser Arg Arg Cys 
        515                 520                 525             


Pro Gly Asp Cys Arg Gly His Gly Leu Cys Glu Asp Gly Val Cys Val 
    530                 535                 540                 


Cys Asp Ala Gly Tyr Ser Gly Glu Asp Cys Ser Thr Arg Ser Cys Pro 
545                 550                 555                 560 


Gly Gly Cys Arg Gly Arg Gly Gln Cys Leu Asp Gly Arg Cys Val Cys 
                565                 570                 575     


Glu Asp Gly Tyr Ser Gly Glu Asp Cys Gly Val Arg Gln Cys Pro Asn 
            580                 585                 590         


Asp Cys Ser Gln His Gly Val Cys Gln Asp Gly Val Cys Ile Cys Trp 
        595                 600                 605             


Glu Gly Tyr Val Ser Glu Asp Cys Ser Ile Arg Thr Cys Pro Ser Asn 
    610                 615                 620                 


Cys His Gly Arg Gly Arg Cys Glu Glu Gly Arg Cys Leu Cys Asp Pro 
625                 630                 635                 640 


Gly Tyr Thr Gly Pro Thr Cys Ala Thr Arg Met Cys Pro Ala Asp Cys 
                645                 650                 655     


Arg Gly Arg Gly Arg Cys Val Gln Gly Val Cys Leu Cys His Val Gly 
            660                 665                 670         


Tyr Gly Gly Glu Asp Cys Gly Gln Glu Glu Pro Pro Ala Ser Ala Cys 
        675                 680                 685             


Pro Gly Gly Cys Gly Pro Arg Glu Leu Cys Arg Ala Gly Gln Cys Val 
    690                 695                 700                 


Cys Val Glu Gly Phe Arg Gly Pro Asp Cys Ala Ile Gln Thr Cys Pro 
705                 710                 715                 720 


Gly Asp Cys Arg Gly Arg Gly Glu Cys His Asp Gly Ser Cys Val Cys 
                725                 730                 735     


Lys Asp Gly Tyr Ala Gly Glu Asp Cys Gly Glu Ala Arg Val Pro Ser 
            740                 745                 750         


Ser Ala Ser Ala Tyr Asp Gln Arg Gly Leu Ala Pro Gly Gln Glu Tyr 
        755                 760                 765             


Gln Val Thr Val Arg Ala Leu Arg Gly Thr Ser Trp Gly Leu Pro Ala 
    770                 775                 780                 


Ser Lys Thr Ile Thr Thr Met Ile Asp Gly Pro Gln Asp Leu Arg Val 
785                 790                 795                 800 


Val Ala Val Thr Pro Thr Thr Leu Glu Leu Gly Trp Leu Arg Pro Gln 
                805                 810                 815     


Ala Glu Val Asp Arg Phe Val Val Ser Tyr Val Ser Ala Gly Asn Gln 
            820                 825                 830         


Arg Val Arg Leu Glu Val Pro Pro Glu Ala Asp Gly Thr Leu Leu Thr 
        835                 840                 845             


Asp Leu Met Pro Gly Val Glu Tyr Val Val Thr Val Thr Ala Glu Arg 
    850                 855                 860                 


Gly Arg Ala Val Ser Tyr Pro Ala Ser Val Arg Ala Asn Thr Glu Glu 
865                 870                 875                 880 


Arg Glu Glu Glu Ser Pro Pro Arg Pro Ser Leu Ser Gln Pro Pro Arg 
                885                 890                 895     


Arg Pro Trp Gly Asn Leu Thr Ala Glu Leu Ser Arg Phe Arg Gly Thr 
            900                 905                 910         


Val Gln Asp Leu Glu Arg His Leu Arg Ala His Gly Tyr Pro Leu Arg 
        915                 920                 925             


Ala Asn Gln Thr Tyr Thr Ser Val Ala Arg His Ile His Glu Tyr Leu 
    930                 935                 940                 


Gln Arg Gln Val Leu Gly Ser Ser Ala Asp Gly Ala Leu Leu Val Ser 
945                 950                 955                 960 


Leu Asp Gly Leu Arg Gly Gln Phe Glu Arg Val Val Leu Arg Trp Arg 
                965                 970                 975     


Pro Gln Pro Pro Ala Glu Gly Pro Gly Gly Glu Leu Thr Val Pro Gly 
            980                 985                 990         


Thr Thr Arg Thr Val Ser Leu Pro  Asp Leu Arg Pro Gly  Thr Thr Tyr 
        995                 1000                 1005             


His Val  Glu Val His Gly Val  Arg Ala Gly Gln Thr  Ser Lys Ser 
    1010                 1015                 1020             


Tyr Ala  Phe Ile Thr Thr Thr  Gly Pro Ser Thr Thr  Gln Gly Ala 
    1025                 1030                 1035             


Gln Ala  Pro Leu Leu Gln Gln  Arg Pro Gln Glu Leu  Gly Glu Leu 
    1040                 1045                 1050             


Arg Val  Leu Gly Arg Asp Glu  Thr Gly Arg Leu Arg  Val Val Trp 
    1055                 1060                 1065             


Thr Ala  Gln Pro Asp Thr Phe  Ala Tyr Phe Gln Leu  Arg Met Arg 
    1070                 1075                 1080             


Val Pro  Glu Gly Pro Gly Ala  His Glu Glu Val Leu  Pro Gly Asp 
    1085                 1090                 1095             


Val Arg  Gln Ala Leu Val Pro  Pro Pro Pro Pro Gly  Thr Pro Tyr 
    1100                 1105                 1110             


Glu Leu  Ser Leu His Gly Val  Pro Pro Gly Gly Lys  Pro Ser Asp 
    1115                 1120                 1125             


Pro Ile  Ile Tyr Gln Gly Ile  Met Asp Lys Asp Glu  Glu Lys Pro 
    1130                 1135                 1140             


Gly Lys  Ser Ser Gly Pro Pro  Arg Leu Gly Glu Leu  Thr Val Thr 
    1145                 1150                 1155             


Asp Arg  Thr Ser Asp Ser Leu  Leu Leu Arg Trp Thr  Val Pro Glu 
    1160                 1165                 1170             


Gly Glu  Phe Asp Ser Phe Val  Ile Gln Tyr Lys Asp  Arg Asp Gly 
    1175                 1180                 1185             


Gln Pro  Gln Val Val Pro Val  Glu Gly Pro Gln Arg  Ser Ala Val 
    1190                 1195                 1200             


Ile Thr  Ser Leu Asp Pro Gly  Arg Lys Tyr Lys Phe  Val Leu Tyr 
    1205                 1210                 1215             


Gly Phe  Val Gly Lys Lys Arg  His Gly Pro Leu Val  Ala Glu Ala 
    1220                 1225                 1230             


Lys Ile  Leu Pro Gln Ser Asp  Pro Ser Pro Gly Thr  Pro Pro His 
    1235                 1240                 1245             


Leu Gly  Asn Leu Trp Val Thr  Asp Pro Thr Pro Asp  Ser Leu His 
    1250                 1255                 1260             


Leu Ser  Trp Thr Val Pro Glu  Gly Gln Phe Asp Thr  Phe Met Val 
    1265                 1270                 1275             


Gln Tyr  Arg Asp Arg Asp Gly  Arg Pro Gln Val Val  Pro Val Glu 
    1280                 1285                 1290             


Gly Pro  Glu Arg Ser Phe Val  Val Ser Ser Leu Asp  Pro Asp His 
    1295                 1300                 1305             


Lys Tyr  Arg Phe Thr Leu Phe  Gly Ile Ala Asn Lys  Lys Arg Tyr 
    1310                 1315                 1320             


Gly Pro  Leu Thr Ala Asp Gly  Thr Thr Ala Pro Glu  Arg Lys Glu 
    1325                 1330                 1335             


Glu Pro  Pro Arg Pro Glu Phe  Leu Glu Gln Pro Leu  Leu Gly Glu 
    1340                 1345                 1350             


Leu Thr  Val Thr Gly Val Thr  Pro Asp Ser Leu Arg  Leu Ser Trp 
    1355                 1360                 1365             


Thr Val  Ala Gln Gly Pro Phe  Asp Ser Phe Met Val  Gln Tyr Lys 
    1370                 1375                 1380             


Asp Ala  Gln Gly Gln Pro Gln  Ala Val Pro Val Ala  Gly Asp Glu 
    1385                 1390                 1395             


Asn Glu  Val Thr Val Pro Gly  Leu Asp Pro Asp Arg  Lys Tyr Lys 
    1400                 1405                 1410             


Met Asn  Leu Tyr Gly Leu Arg  Gly Arg Gln Arg Val  Gly Pro Glu 
    1415                 1420                 1425             


Ser Val  Val Ala Lys Thr Ala  Pro Gln Glu Asp Val  Asp Glu Thr 
    1430                 1435                 1440             


Pro Ser  Pro Thr Glu Leu Gly  Thr Glu Ala Pro Glu  Ser Pro Glu 
    1445                 1450                 1455             


Glu Pro  Leu Leu Gly Glu Leu  Thr Val Thr Gly Ser  Ser Pro Asp 
    1460                 1465                 1470             


Ser Leu  Ser Leu Phe Trp Thr  Val Pro Gln Gly Ser  Phe Asp Ser 
    1475                 1480                 1485             


Phe Thr  Val Gln Tyr Lys Asp  Arg Asp Gly Arg Pro  Arg Ala Val 
    1490                 1495                 1500             


Arg Val  Gly Gly Lys Glu Ser  Glu Val Thr Val Gly  Gly Leu Glu 
    1505                 1510                 1515             


Pro Gly  His Lys Tyr Lys Met  His Leu Tyr Gly Leu  His Glu Gly 
    1520                 1525                 1530             


Gln Arg  Val Gly Pro Val Ser  Ala Val Gly Val Thr  Ala Pro Gln 
    1535                 1540                 1545             


Gln Glu  Glu Thr Pro Pro Ala  Thr Glu Ser Pro Leu  Glu Pro Arg 
    1550                 1555                 1560             


Leu Gly  Glu Leu Thr Val Thr  Asp Val Thr Pro Asn  Ser Val Gly 
    1565                 1570                 1575             


Leu Ser  Trp Thr Val Pro Glu  Gly Gln Phe Asp Ser  Phe Ile Val 
    1580                 1585                 1590             


Gln Tyr  Lys Asp Lys Asp Gly  Gln Pro Gln Val Val  Pro Val Ala 
    1595                 1600                 1605             


Ala Asp  Gln Arg Glu Val Thr  Val Tyr Asn Leu Glu  Pro Glu Arg 
    1610                 1615                 1620             


Lys Tyr  Lys Met Asn Met Tyr  Gly Leu His Asp Gly  Gln Arg Met 
    1625                 1630                 1635             


Gly Pro  Leu Ser Val Val Ile  Val Thr Ala Pro Ala  Thr Glu Ala 
    1640                 1645                 1650             


Ser Lys  Pro Pro Leu Glu Pro  Arg Leu Gly Glu Leu  Thr Val Thr 
    1655                 1660                 1665             


Asp Ile  Thr Pro Asp Ser Val  Gly Leu Ser Trp Thr  Val Pro Glu 
    1670                 1675                 1680             


Gly Glu  Phe Asp Ser Phe Val  Val Gln Tyr Lys Asp  Arg Asp Gly 
    1685                 1690                 1695             


Gln Pro  Gln Val Val Pro Val  Ala Ala Asp Gln Arg  Glu Val Thr 
    1700                 1705                 1710             


Ile Pro  Asp Leu Glu Pro Ser  Arg Lys Tyr Lys Phe  Leu Leu Phe 
    1715                 1720                 1725             


Gly Ile  Gln Asp Gly Lys Arg  Arg Ser Pro Val Ser  Val Glu Ala 
    1730                 1735                 1740             


Lys Thr  Val Ala Arg Gly Asp  Ala Ser Pro Gly Ala  Pro Pro Arg 
    1745                 1750                 1755             


Leu Gly  Glu Leu Trp Val Thr  Asp Pro Thr Pro Asp  Ser Leu Arg 
    1760                 1765                 1770             


Leu Ser  Trp Thr Val Pro Glu  Gly Gln Phe Asp Ser  Phe Val Val 
    1775                 1780                 1785             


Gln Phe  Lys Asp Lys Asp Gly  Pro Gln Val Val Pro  Val Glu Gly 
    1790                 1795                 1800             


His Glu  Arg Ser Val Thr Val  Thr Pro Leu Asp Ala  Gly Arg Lys 
    1805                 1810                 1815             


Tyr Arg  Phe Leu Leu Tyr Gly  Leu Leu Gly Lys Lys  Arg His Gly 
    1820                 1825                 1830             


Pro Leu  Thr Ala Asp Gly Thr  Thr Glu Ala Arg Ser  Ala Met Asp 
    1835                 1840                 1845             


Asp Thr  Gly Thr Lys Arg Pro  Pro Lys Pro Arg Leu  Gly Glu Glu 
    1850                 1855                 1860             


Leu Gln  Val Thr Thr Val Thr  Gln Asn Ser Val Gly  Leu Ser Trp 
    1865                 1870                 1875             


Thr Val  Pro Glu Gly Gln Phe  Asp Ser Phe Val Val  Gln Tyr Lys 
    1880                 1885                 1890             


Asp Arg  Asp Gly Gln Pro Gln  Val Val Pro Val Glu  Gly Ser Leu 
    1895                 1900                 1905             


Arg Glu  Val Ser Val Pro Gly  Leu Asp Pro Ala His  Arg Tyr Lys 
    1910                 1915                 1920             


Leu Leu  Leu Tyr Gly Leu His  His Gly Lys Arg Val  Gly Pro Ile 
    1925                 1930                 1935             


Ser Ala  Val Ala Ile Thr Ala  Gly Arg Glu Glu Thr  Glu Thr Glu 
    1940                 1945                 1950             


Thr Thr  Ala Pro Thr Pro Pro  Ala Pro Glu Pro His  Leu Gly Glu 
    1955                 1960                 1965             


Leu Thr  Val Glu Glu Ala Thr  Ser His Thr Leu His  Leu Ser Trp 
    1970                 1975                 1980             


Met Val  Thr Glu Gly Glu Phe  Asp Ser Phe Glu Ile  Gln Tyr Thr 
    1985                 1990                 1995             


Asp Arg  Asp Gly Gln Leu Gln  Met Val Arg Ile Gly  Gly Asp Arg 
    2000                 2005                 2010             


Asn Asp  Ile Thr Leu Ser Gly  Leu Glu Ser Asp His  Arg Tyr Leu 
    2015                 2020                 2025             


Val Thr  Leu Tyr Gly Phe Ser  Asp Gly Lys His Val  Gly Pro Val 
    2030                 2035                 2040             


His Val  Glu Ala Leu Thr Val  Pro Glu Glu Glu Lys  Pro Ser Glu 
    2045                 2050                 2055             


Pro Pro  Thr Ala Thr Pro Glu  Pro Pro Ile Lys Pro  Arg Leu Gly 
    2060                 2065                 2070             


Glu Leu  Thr Val Thr Asp Ala  Thr Pro Asp Ser Leu  Ser Leu Ser 
    2075                 2080                 2085             


Trp Thr  Val Pro Glu Gly Gln  Phe Asp His Phe Leu  Val Gln Tyr 
    2090                 2095                 2100             


Arg Asn  Gly Asp Gly Gln Pro  Lys Ala Val Arg Val  Pro Gly His 
    2105                 2110                 2115             


Glu Glu  Gly Val Thr Ile Ser  Gly Leu Glu Pro Asp  His Lys Tyr 
    2120                 2125                 2130             


Lys Met  Asn Leu Tyr Gly Phe  His Gly Gly Gln Arg  Met Gly Pro 
    2135                 2140                 2145             


Val Ser  Val Val Gly Val Thr  Glu Pro Ser Met Glu  Ala Pro Glu 
    2150                 2155                 2160             


Pro Ala  Glu Glu Pro Leu Leu  Gly Glu Leu Thr Val  Thr Gly Ser 
    2165                 2170                 2175             


Ser Pro  Asp Ser Leu Ser Leu  Ser Trp Thr Val Pro  Gln Gly Arg 
    2180                 2185                 2190             


Phe Asp  Ser Phe Thr Val Gln  Tyr Lys Asp Arg Asp  Gly Arg Pro 
    2195                 2200                 2205             


Gln Val  Val Arg Val Gly Gly  Glu Glu Ser Glu Val  Thr Val Gly 
    2210                 2215                 2220             


Gly Leu  Glu Pro Gly Arg Lys  Tyr Lys Met His Leu  Tyr Gly Leu 
    2225                 2230                 2235             


His Glu  Gly Arg Arg Val Gly  Pro Val Ser Ala Val  Gly Val Thr 
    2240                 2245                 2250             


Ala Pro  Glu Glu Glu Ser Pro  Asp Ala Pro Leu Ala  Lys Leu Arg 
    2255                 2260                 2265             


Leu Gly  Gln Met Thr Val Arg  Asp Ile Thr Ser Asp  Ser Leu Ser 
    2270                 2275                 2280             


Leu Ser  Trp Thr Val Pro Glu  Gly Gln Phe Asp His  Phe Leu Val 
    2285                 2290                 2295             


Gln Phe  Lys Asn Gly Asp Gly  Gln Pro Lys Ala Val  Arg Val Pro 
    2300                 2305                 2310             


Gly His  Glu Asp Gly Val Thr  Ile Ser Gly Leu Glu  Pro Asp His 
    2315                 2320                 2325             


Lys Tyr  Lys Met Asn Leu Tyr  Gly Phe His Gly Gly  Gln Arg Val 
    2330                 2335                 2340             


Gly Pro  Val Ser Ala Val Gly  Leu Thr Ala Ser Thr  Glu Pro Pro 
    2345                 2350                 2355             


Thr Pro  Glu Pro Pro Ile Lys  Pro Arg Leu Glu Glu  Leu Thr Val 
    2360                 2365                 2370             


Thr Asp  Ala Thr Pro Asp Ser  Leu Ser Leu Ser Trp  Thr Val Pro 
    2375                 2380                 2385             


Glu Gly  Gln Phe Asp His Phe  Leu Val Gln Tyr Lys  Asn Gly Asp 
    2390                 2395                 2400             


Gly Gln  Pro Lys Ala Thr Arg  Val Pro Gly His Glu  Asp Arg Val 
    2405                 2410                 2415             


Thr Ile  Ser Gly Leu Glu Pro  Asp Asn Lys Tyr Lys  Met Asn Leu 
    2420                 2425                 2430             


Tyr Gly  Phe His Gly Gly Gln  Arg Val Gly Pro Val  Ser Ala Ile 
    2435                 2440                 2445             


Gly Val  Thr Glu Glu Glu Thr  Pro Ser Pro Thr Glu  Pro Ser Met 
    2450                 2455                 2460             


Glu Ala  Pro Glu Pro Pro Glu  Glu Pro Leu Leu Gly  Glu Leu Thr 
    2465                 2470                 2475             


Val Thr  Gly Ser Ser Pro Asp  Ser Leu Ser Leu Ser  Trp Thr Val 
    2480                 2485                 2490             


Pro Gln  Gly Arg Phe Asp Ser  Phe Thr Val Gln Tyr  Lys Asp Arg 
    2495                 2500                 2505             


Asp Gly  Arg Pro Gln Val Val  Arg Val Gly Gly Glu  Glu Ser Glu 
    2510                 2515                 2520             


Val Thr  Val Gly Gly Leu Glu  Pro Gly Arg Lys Tyr  Lys Met His 
    2525                 2530                 2535             


Leu Tyr  Gly Leu His Glu Gly  Arg Arg Val Gly Pro  Val Ser Thr 
    2540                 2545                 2550             


Val Gly  Val Thr Ala Pro Gln  Glu Asp Val Asp Glu  Thr Pro Ser 
    2555                 2560                 2565             


Pro Thr  Glu Pro Gly Thr Glu  Ala Pro Gly Pro Pro  Glu Glu Pro 
    2570                 2575                 2580             


Leu Leu  Gly Glu Leu Thr Val  Thr Gly Ser Ser Pro  Asp Ser Leu 
    2585                 2590                 2595             


Ser Leu  Ser Trp Thr Val Pro  Gln Gly Arg Phe Asp  Ser Phe Thr 
    2600                 2605                 2610             


Val Gln  Tyr Lys Asp Arg Asp  Gly Arg Pro Gln Ala  Val Arg Val 
    2615                 2620                 2625             


Gly Gly  Gln Glu Ser Lys Val  Thr Val Arg Gly Leu  Glu Pro Gly 
    2630                 2635                 2640             


Arg Lys  Tyr Lys Met His Leu  Tyr Gly Leu His Glu  Gly Arg Arg 
    2645                 2650                 2655             


Leu Gly  Pro Val Ser Ala Val  Gly Val Thr Glu Asp  Glu Ala Glu 
    2660                 2665                 2670             


Thr Thr  Gln Ala Val Pro Thr  Met Thr Pro Glu Pro  Pro Ile Lys 
    2675                 2680                 2685             


Pro Arg  Leu Gly Glu Leu Thr  Met Thr Asp Ala Thr  Pro Asp Ser 
    2690                 2695                 2700             


Leu Ser  Leu Ser Trp Thr Val  Pro Glu Gly Gln Phe  Asp His Phe 
    2705                 2710                 2715             


Leu Val  Gln Tyr Arg Asn Gly  Asp Gly Gln Pro Lys  Ala Val Arg 
    2720                 2725                 2730             


Val Pro  Gly His Glu Asp Gly  Val Thr Ile Ser Gly  Leu Glu Pro 
    2735                 2740                 2745             


Asp His  Lys Tyr Lys Met Asn  Leu Tyr Gly Phe His  Gly Gly Gln 
    2750                 2755                 2760             


Arg Val  Gly Pro Ile Ser Val  Ile Gly Val Thr Glu  Glu Glu Thr 
    2765                 2770                 2775             


Pro Ser  Pro Thr Glu Leu Ser  Thr Glu Ala Pro Glu  Pro Pro Glu 
    2780                 2785                 2790             


Glu Pro  Leu Leu Gly Glu Leu  Thr Val Thr Gly Ser  Ser Pro Asp 
    2795                 2800                 2805             


Ser Leu  Ser Leu Ser Trp Thr  Ile Pro Gln Gly His  Phe Asp Ser 
    2810                 2815                 2820             


Phe Thr  Val Gln Tyr Lys Asp  Arg Asp Gly Arg Pro  Gln Val Met 
    2825                 2830                 2835             


Arg Val  Arg Gly Glu Glu Ser  Glu Val Thr Val Gly  Gly Leu Glu 
    2840                 2845                 2850             


Pro Gly  Arg Lys Tyr Lys Met  His Leu Tyr Gly Leu  His Glu Gly 
    2855                 2860                 2865             


Arg Arg  Val Gly Pro Val Ser  Thr Val Gly Val Thr  Val Pro Thr 
    2870                 2875                 2880             


Thr Thr  Pro Glu Pro Pro Asn  Lys Pro Arg Leu Gly  Glu Leu Thr 
    2885                 2890                 2895             


Val Thr  Asp Ala Thr Pro Asp  Ser Leu Ser Leu Ser  Trp Met Val 
    2900                 2905                 2910             


Pro Glu  Gly Gln Phe Asp His  Phe Leu Val Gln Tyr  Arg Asn Gly 
    2915                 2920                 2925             


Asp Gly  Gln Pro Lys Val Val  Arg Val Pro Gly His  Glu Asp Gly 
    2930                 2935                 2940             


Val Thr  Ile Ser Gly Leu Glu  Pro Asp His Lys Tyr  Lys Met Asn 
    2945                 2950                 2955             


Leu Tyr  Gly Phe His Gly Gly  Gln Arg Val Gly Pro  Ile Ser Val 
    2960                 2965                 2970             


Ile Gly  Val Thr Glu Glu Glu  Thr Pro Ala Pro Thr  Glu Pro Ser 
    2975                 2980                 2985             


Thr Glu  Ala Pro Glu Pro Pro  Glu Glu Pro Leu Leu  Gly Glu Leu 
    2990                 2995                 3000             


Thr Val  Thr Gly Ser Ser Pro  Asp Ser Leu Ser Leu  Ser Trp Thr 
    3005                 3010                 3015             


Ile Pro  Gln Gly Arg Phe Asp  Ser Phe Thr Val Gln  Tyr Lys Asp 
    3020                 3025                 3030             


Arg Asp  Gly Arg Pro Gln Val  Val Arg Val Arg Gly  Glu Glu Ser 
    3035                 3040                 3045             


Glu Val  Thr Val Gly Gly Leu  Glu Pro Gly Cys Lys  Tyr Lys Met 
    3050                 3055                 3060             


His Leu  Tyr Gly Leu His Glu  Gly Gln Arg Val Gly  Pro Val Ser 
    3065                 3070                 3075             


Ala Val  Gly Val Thr Ala Pro  Lys Asp Glu Ala Glu  Thr Thr Gln 
    3080                 3085                 3090             


Ala Val  Pro Thr Met Thr Pro  Glu Pro Pro Ile Lys  Pro Arg Leu 
    3095                 3100                 3105             


Gly Glu  Leu Thr Val Thr Asp  Ala Thr Pro Asp Ser  Leu Ser Leu 
    3110                 3115                 3120             


Ser Trp  Met Val Pro Glu Gly  Gln Phe Asp His Phe  Leu Val Gln 
    3125                 3130                 3135             


Tyr Arg  Asn Gly Asp Gly Gln  Pro Lys Ala Val Arg  Val Pro Gly 
    3140                 3145                 3150             


His Glu  Asp Gly Val Thr Ile  Ser Gly Leu Glu Pro  Asp His Lys 
    3155                 3160                 3165             


Tyr Lys  Met Asn Leu Tyr Gly  Phe His Gly Gly Gln  Arg Val Gly 
    3170                 3175                 3180             


Pro Val  Ser Ala Ile Gly Val  Thr Glu Glu Glu Thr  Pro Ser Pro 
    3185                 3190                 3195             


Thr Glu  Pro Ser Thr Glu Ala  Pro Glu Ala Pro Glu  Glu Pro Leu 
    3200                 3205                 3210             


Leu Gly  Glu Leu Thr Val Thr  Gly Ser Ser Pro Asp  Ser Leu Ser 
    3215                 3220                 3225             


Leu Ser  Trp Thr Val Pro Gln  Gly Arg Phe Asp Ser  Phe Thr Val 
    3230                 3235                 3240             


Gln Tyr  Lys Asp Arg Asp Gly  Gln Pro Gln Val Val  Arg Val Arg 
    3245                 3250                 3255             


Gly Glu  Glu Ser Glu Val Thr  Val Gly Gly Leu Glu  Pro Gly Arg 
    3260                 3265                 3270             


Lys Tyr  Lys Met His Leu Tyr  Gly Leu His Glu Gly  Gln Arg Val 
    3275                 3280                 3285             


Gly Pro  Val Ser Thr Val Gly  Ile Thr Ala Pro Leu  Pro Thr Pro 
    3290                 3295                 3300             


Leu Pro  Val Glu Pro Arg Leu  Gly Glu Leu Ala Val  Ala Ala Val 
    3305                 3310                 3315             


Thr Ser  Asp Ser Val Gly Leu  Ser Trp Thr Val Ala  Gln Gly Pro 
    3320                 3325                 3330             


Phe Asp  Ser Phe Leu Val Gln  Tyr Arg Asp Ala Gln  Gly Gln Pro 
    3335                 3340                 3345             


Gln Ala  Val Pro Val Ser Gly  Asp Leu Arg Ala Val  Ala Val Ser 
    3350                 3355                 3360             


Gly Leu  Asp Pro Ala Arg Lys  Tyr Lys Phe Leu Leu  Phe Gly Leu 
    3365                 3370                 3375             


Gln Asn  Gly Lys Arg His Gly  Pro Val Pro Val Glu  Ala Arg Thr 
    3380                 3385                 3390             


Ala Pro  Asp Thr Lys Pro Ser  Pro Arg Leu Gly Glu  Leu Thr Val 
    3395                 3400                 3405             


Thr Asp  Ala Thr Pro Asp Ser  Val Gly Leu Ser Trp  Thr Val Pro 
    3410                 3415                 3420             


Glu Gly  Glu Phe Asp Ser Phe  Val Val Gln Tyr Lys  Asp Lys Asp 
    3425                 3430                 3435             


Gly Arg  Leu Gln Val Val Pro  Val Ala Ala Asn Gln  Arg Glu Val 
    3440                 3445                 3450             


Thr Val  Gln Gly Leu Glu Pro  Ser Arg Lys Tyr Arg  Phe Leu Leu 
    3455                 3460                 3465             


Tyr Gly  Leu Ser Gly Arg Lys  Arg Leu Gly Pro Ile  Ser Ala Asp 
    3470                 3475                 3480             


Ser Thr  Thr Ala Pro Leu Glu  Lys Glu Leu Pro Pro  His Leu Gly 
    3485                 3490                 3495             


Glu Leu  Thr Val Ala Glu Glu  Thr Ser Ser Ser Leu  Arg Leu Ser 
    3500                 3505                 3510             


Trp Thr  Val Ala Gln Gly Pro  Phe Asp Ser Phe Val  Val Gln Tyr 
    3515                 3520                 3525             


Arg Asp  Thr Asp Gly Gln Pro  Arg Ala Val Pro Val  Ala Ala Asp 
    3530                 3535                 3540             


Gln Arg  Thr Val Thr Val Glu  Asp Leu Glu Pro Gly  Lys Lys Tyr 
    3545                 3550                 3555             


Lys Phe  Leu Leu Tyr Gly Leu  Leu Gly Gly Lys Arg  Leu Gly Pro 
    3560                 3565                 3570             


Val Ser  Ala Leu Gly Met Thr  Ala Pro Glu Glu Asp  Thr Pro Ala 
    3575                 3580                 3585             


Pro Glu  Leu Ala Pro Glu Ala  Pro Glu Pro Pro Glu  Glu Pro Arg 
    3590                 3595                 3600             


Leu Gly  Val Leu Thr Val Thr  Asp Thr Thr Pro Asp  Ser Met Arg 
    3605                 3610                 3615             


Leu Ser  Trp Ser Val Ala Gln  Gly Pro Phe Asp Ser  Phe Val Val 
    3620                 3625                 3630             


Gln Tyr  Glu Asp Thr Asn Gly  Gln Pro Gln Ala Leu  Leu Val Asp 
    3635                 3640                 3645             


Gly Asp  Gln Ser Lys Ile Leu  Ile Ser Gly Leu Glu  Pro Ser Thr 
    3650                 3655                 3660             


Pro Tyr  Arg Phe Leu Leu Tyr  Gly Leu His Glu Gly  Lys Arg Leu 
    3665                 3670                 3675             


Gly Pro  Leu Ser Ala Glu Gly  Thr Thr Gly Leu Ala  Pro Ala Gly 
    3680                 3685                 3690             


Gln Thr  Ser Glu Glu Ser Arg  Pro Arg Leu Ser Gln  Leu Ser Val 
    3695                 3700                 3705             


Thr Asp  Val Thr Thr Ser Ser  Leu Arg Leu Asn Trp  Glu Ala Pro 
    3710                 3715                 3720             


Pro Gly  Ala Phe Asp Ser Phe  Leu Leu Arg Phe Gly  Val Pro Ser 
    3725                 3730                 3735             


Pro Ser  Thr Leu Glu Pro His  Pro Arg Pro Leu Leu  Gln Arg Glu 
    3740                 3745                 3750             


Leu Met  Val Pro Gly Thr Arg  His Ser Ala Val Leu  Arg Asp Leu 
    3755                 3760                 3765             


Arg Ser  Gly Thr Leu Tyr Ser  Leu Thr Leu Tyr Gly  Leu Arg Gly 
    3770                 3775                 3780             


Pro His  Lys Ala Asp Ser Ile  Gln Gly Thr Ala Arg  Thr Leu Ser 
    3785                 3790                 3795             


Pro Val  Leu Glu Ser Pro Arg  Asp Leu Gln Phe Ser  Glu Ile Arg 
    3800                 3805                 3810             


Glu Thr  Ser Ala Lys Val Asn  Trp Met Pro Pro Pro  Ser Arg Ala 
    3815                 3820                 3825             


Asp Ser  Phe Lys Val Ser Tyr  Gln Leu Ala Asp Gly  Gly Glu Pro 
    3830                 3835                 3840             


Gln Ser  Val Gln Val Asp Gly  Gln Ala Arg Thr Gln  Lys Leu Gln 
    3845                 3850                 3855             


Gly Leu  Ile Pro Gly Ala Arg  Tyr Glu Val Thr Val  Val Ser Val 
    3860                 3865                 3870             


Arg Gly  Phe Glu Glu Ser Glu  Pro Leu Thr Gly Phe  Leu Thr Thr 
    3875                 3880                 3885             


Val Pro  Asp Gly Pro Thr Gln  Leu Arg Ala Leu Asn  Leu Thr Glu 
    3890                 3895                 3900             


Gly Phe  Ala Val Leu His Trp  Lys Pro Pro Gln Asn  Pro Val Asp 
    3905                 3910                 3915             


Thr Tyr  Asp Val Gln Val Thr  Ala Pro Gly Ala Pro  Pro Leu Gln 
    3920                 3925                 3930             


Ala Glu  Thr Pro Gly Ser Ala  Val Asp Tyr Pro Leu  His Asp Leu 
    3935                 3940                 3945             


Val Leu  His Thr Asn Tyr Thr  Ala Thr Val Arg Gly  Leu Arg Gly 
    3950                 3955                 3960             


Pro Asn  Leu Thr Ser Pro Ala  Ser Ile Thr Phe Thr  Thr Gly Leu 
    3965                 3970                 3975             


Glu Ala  Pro Arg Asp Leu Glu  Ala Lys Glu Val Thr  Pro Arg Thr 
    3980                 3985                 3990             


Ala Leu  Leu Thr Trp Thr Glu  Pro Pro Val Arg Pro  Ala Gly Tyr 
    3995                 4000                 4005             


Leu Leu  Ser Phe His Thr Pro  Gly Gly Gln Asn Gln  Glu Ile Leu 
    4010                 4015                 4020             


Leu Pro  Gly Gly Ile Thr Ser  His Gln Leu Leu Gly  Leu Phe Pro 
    4025                 4030                 4035             


Ser Thr  Ser Tyr Asn Ala Arg  Leu Gln Ala Met Trp  Gly Gln Ser 
    4040                 4045                 4050             


Leu Leu  Pro Pro Val Ser Thr  Ser Phe Thr Thr Gly  Gly Leu Arg 
    4055                 4060                 4065             


Ile Pro  Phe Pro Arg Asp Cys  Gly Glu Glu Met Gln  Asn Gly Ala 
    4070                 4075                 4080             


Gly Ala  Ser Arg Thr Ser Thr  Ile Phe Leu Asn Gly  Asn Arg Glu 
    4085                 4090                 4095             


Arg Pro  Leu Asn Val Phe Cys  Asp Met Glu Thr Asp  Gly Gly Gly 
    4100                 4105                 4110             


Trp Leu  Val Phe Gln Arg Arg  Met Asp Gly Gln Thr  Asp Phe Trp 
    4115                 4120                 4125             


Arg Asp  Trp Glu Asp Tyr Ala  His Gly Phe Gly Asn  Ile Ser Gly 
    4130                 4135                 4140             


Glu Phe  Trp Leu Gly Asn Glu  Ala Leu His Ser Leu  Thr Gln Ala 
    4145                 4150                 4155             


Gly Asp  Tyr Ser Met Arg Val  Asp Leu Arg Ala Gly  Asp Glu Ala 
    4160                 4165                 4170             


Val Phe  Ala Gln Tyr Asp Ser  Phe His Val Asp Ser  Ala Ala Glu 
    4175                 4180                 4185             


Tyr Tyr  Arg Leu His Leu Glu  Gly Tyr His Gly Thr  Ala Gly Asp 
    4190                 4195                 4200             


Ser Met  Ser Tyr His Ser Gly  Ser Val Phe Ser Ala  Arg Asp Arg 
    4205                 4210                 4215             


Asp Pro  Asn Ser Leu Leu Ile  Ser Cys Ala Val Ser  Tyr Arg Gly 
    4220                 4225                 4230             


Ala Trp  Trp Tyr Arg Asn Cys  His Tyr Ala Asn Leu  Asn Gly Leu 
    4235                 4240                 4245             


Tyr Gly  Ser Thr Val Asp His  Gln Gly Val Ser Trp  Tyr His Trp 
    4250                 4255                 4260             


Lys Gly  Phe Glu Phe Ser Val  Pro Phe Thr Glu Met  Lys Leu Arg 
    4265                 4270                 4275             


Pro Arg  Asn Phe Arg Ser Pro  Ala Gly Gly Gly 
    4280                 4285                 


<210>  1645
<211>  3129
<212>  DNA
<213>  Homosapiens

<400>  1645
ccttgtgcat ttgggctgaa gacaaagatg actgcaggag tgggcaggcc ggagtggggc     60

gccctggcct gtccccagga aggaggagga gtctgcagcc ctgtgggctt caacatccat    120

caaggagtcc agagcaggag ccaggccagg cgggagggaa aggccctggg aggggctctc    180

taatctccca gccccgactc tgccccgtca ctgccactgc tcctcattac tcgctggggc    240

tgctgtcgcc tccccgaagg gtggccttgt ccagatagcg gcaaacctcc ctgccgtgga    300

tgagtcagga gcattttctt aagaggaaca tcactggaaa acaaaatgag cggggacaca    360

gaaaccaaca gcagtggctg catttgtggt acaggctcct cttccagagc tcgctgatgc    420

ccacctcaga caggcctgac cacggcacgg ctggtgggat ttgccagtca cctcaaccag    480

ccagttccac cctcagcttc tctcagaagg gagcaccaca ctcctcaagc tcagtgaatg    540

tatcccggca tgggtggggc cagagcctgt gatatctcga ggtgggctcg gcaggacacc    600

ggggtgtgga agggggaagc gagcacctga ctcagacagc gcgggagctc gcaggagtca    660

cgaggccaca gcgacttcat tgtctgactg ggcctggacc tataaacttc ccacctcagc    720

cttgggccaa gcctggaaga taaaaatgga gcaccccatg gcgcccctca ctcagattct    780

cccctgggct tctcccacgc agccccagaa gaggacacac cagccccaga gttagcccca    840

gaggcccctg agcctcctga agagccccgc ctaggagtgc tgaccgtgac cgacacaacc    900

ccagactcca tgcgcctctc gtggagcgtg gcccagggcc cctttgattc cttcgtggtc    960

cagtatgagg acacgaacgg gcagccccag gccttgctcg tggacggcga ccagagcaag   1020

atcctcatct caggcctgga gcccagcacc ccctacaggt tcctcctcta tggcctccat   1080

gaagggaagc gcctggggcc cctctcagct gagggcacca cagggctggc tcctgctggt   1140

cagacctcag aggagtcaag gccccgcctg tcccagctgt ctgtgactga cgtgaccacc   1200

agttcactga ggctcaactg ggaggcccca ccgggggcct tcgactcctt cctgctccgc   1260

tttggggttc catcaccaag cactctggag ccgcatccgc gtccactgct gcagcgcgag   1320

ctgatggtgc cggggacacg gcactcggcc gtgctccggg acctgcgttc cgggactctg   1380

tacagcctga cactgtatgg gctgcgagga ccccacaagg ccgacagcat ccagggaacc   1440

gcccgcaccc tcagcccagt tctggagagc ccccgtgacc tccaattcag tgaaatcagg   1500

gagacctcag ccaaggtcaa ctggatgccc ccaccatccc gggcggacag cttcaaagtc   1560

tcctaccagc tggcggacgg aggggagcct cagagtgtgc aggtggatgg ccaggcccgg   1620

acccagaaac tccaggggct gatcccaggc gctcgctatg aggtgaccgt ggtctcggtc   1680

cgaggctttg aggagagtga gcctctcaca ggcttcctca ccacggttcc tgacggtccc   1740

acacagttgc gtgcactgaa cttgaccgag ggattcgccg tgctgcactg gaagcccccc   1800

cagaatcctg tggacaccta tgacgtccag gtcacagccc ctggggcccc gcctctgcag   1860

gcggagaccc caggcagcgc ggtggactac cccctgcatg accttgtcct ccacaccaac   1920

tacaccgcca cagtgcgtgg cctgcggggc cccaacctca cttccccagc cagcatcacc   1980

ttcaccacag ggctagaggc ccctcgggac ttggaggcca aggaagtgac cccccgcacc   2040

gccctgctca cttggactga gcccccagtc cggcccgcag gctacctgct cagcttccac   2100

acccctggtg gacagaacca ggagatcctg ctcccaggag ggatcacatc tcaccagctc   2160

cttggcctct ttccctccac ctcctacaat gcacggctcc aggccatgtg gggccagagc   2220

ctcctgccgc ccgtgtccac ctctttcacc acgggtgggc tgcggatccc cttccccagg   2280

gactgcgggg aggagatgca gaacggagcc ggtgcctcca ggaccagcac catcttcctc   2340

aacggcaacc gcgagcggcc cctgaacgtg ttttgcgaca tggagactga tgggggcggc   2400

tggctggtgt tccagcgccg catggatgga cagacagact tctggaggga ctgggaggac   2460

tatgcccatg gttttgggaa catctctgga gagttctggc tgggcaatga ggccctgcac   2520

agcctgacac aggcaggtga ctactccatg cgcgtggacc tgcgggctgg ggacgaggct   2580

gtgttcgccc agtacgactc cttccacgta gactcggctg cggagtacta ccgcctccac   2640

ttggagggct accacggcac cgcaggggac tccatgagct accacagcgg cagtgtcttc   2700

tctgcccgtg atcgggaccc caacagcttg ctcatctcct gcgctgtctc ctaccgaggg   2760

gcctggtggt acaggaactg ccactacgcc aacctcaacg ggctctacgg gagcacagtg   2820

gaccatcagg gagtgagctg gtaccactgg aagggcttcg agttctcggt gcccttcacg   2880

gaaatgaagc tgagaccaag aaactttcgc tccccagcgg ggggaggctg agctgctgcc   2940

cacctctctc gcaccccagt atgactgccg agcactgagg ggtcgccccg agagaagagc   3000

cagggtcctt caccacccag ccgctggagg aagccttctc tgccagcgat ctcgcagcac   3060

tgtgtttaca ggggggaggg gaggggttcg tacaggagca ataaaggaga aactgaggta   3120

cccggaaaa                                                           3129


<210>  1646
<211>  673
<212>  PRT
<213>  Homosapiens

<400>  1646

Met Arg Leu Ser Trp Ser Val Ala Gln Gly Pro Phe Asp Ser Phe Val 
1               5                   10                  15      


Val Gln Tyr Glu Asp Thr Asn Gly Gln Pro Gln Ala Leu Leu Val Asp 
            20                  25                  30          


Gly Asp Gln Ser Lys Ile Leu Ile Ser Gly Leu Glu Pro Ser Thr Pro 
        35                  40                  45              


Tyr Arg Phe Leu Leu Tyr Gly Leu His Glu Gly Lys Arg Leu Gly Pro 
    50                  55                  60                  


Leu Ser Ala Glu Gly Thr Thr Gly Leu Ala Pro Ala Gly Gln Thr Ser 
65                  70                  75                  80  


Glu Glu Ser Arg Pro Arg Leu Ser Gln Leu Ser Val Thr Asp Val Thr 
                85                  90                  95      


Thr Ser Ser Leu Arg Leu Asn Trp Glu Ala Pro Pro Gly Ala Phe Asp 
            100                 105                 110         


Ser Phe Leu Leu Arg Phe Gly Val Pro Ser Pro Ser Thr Leu Glu Pro 
        115                 120                 125             


His Pro Arg Pro Leu Leu Gln Arg Glu Leu Met Val Pro Gly Thr Arg 
    130                 135                 140                 


His Ser Ala Val Leu Arg Asp Leu Arg Ser Gly Thr Leu Tyr Ser Leu 
145                 150                 155                 160 


Thr Leu Tyr Gly Leu Arg Gly Pro His Lys Ala Asp Ser Ile Gln Gly 
                165                 170                 175     


Thr Ala Arg Thr Leu Ser Pro Val Leu Glu Ser Pro Arg Asp Leu Gln 
            180                 185                 190         


Phe Ser Glu Ile Arg Glu Thr Ser Ala Lys Val Asn Trp Met Pro Pro 
        195                 200                 205             


Pro Ser Arg Ala Asp Ser Phe Lys Val Ser Tyr Gln Leu Ala Asp Gly 
    210                 215                 220                 


Gly Glu Pro Gln Ser Val Gln Val Asp Gly Gln Ala Arg Thr Gln Lys 
225                 230                 235                 240 


Leu Gln Gly Leu Ile Pro Gly Ala Arg Tyr Glu Val Thr Val Val Ser 
                245                 250                 255     


Val Arg Gly Phe Glu Glu Ser Glu Pro Leu Thr Gly Phe Leu Thr Thr 
            260                 265                 270         


Val Pro Asp Gly Pro Thr Gln Leu Arg Ala Leu Asn Leu Thr Glu Gly 
        275                 280                 285             


Phe Ala Val Leu His Trp Lys Pro Pro Gln Asn Pro Val Asp Thr Tyr 
    290                 295                 300                 


Asp Val Gln Val Thr Ala Pro Gly Ala Pro Pro Leu Gln Ala Glu Thr 
305                 310                 315                 320 


Pro Gly Ser Ala Val Asp Tyr Pro Leu His Asp Leu Val Leu His Thr 
                325                 330                 335     


Asn Tyr Thr Ala Thr Val Arg Gly Leu Arg Gly Pro Asn Leu Thr Ser 
            340                 345                 350         


Pro Ala Ser Ile Thr Phe Thr Thr Gly Leu Glu Ala Pro Arg Asp Leu 
        355                 360                 365             


Glu Ala Lys Glu Val Thr Pro Arg Thr Ala Leu Leu Thr Trp Thr Glu 
    370                 375                 380                 


Pro Pro Val Arg Pro Ala Gly Tyr Leu Leu Ser Phe His Thr Pro Gly 
385                 390                 395                 400 


Gly Gln Asn Gln Glu Ile Leu Leu Pro Gly Gly Ile Thr Ser His Gln 
                405                 410                 415     


Leu Leu Gly Leu Phe Pro Ser Thr Ser Tyr Asn Ala Arg Leu Gln Ala 
            420                 425                 430         


Met Trp Gly Gln Ser Leu Leu Pro Pro Val Ser Thr Ser Phe Thr Thr 
        435                 440                 445             


Gly Gly Leu Arg Ile Pro Phe Pro Arg Asp Cys Gly Glu Glu Met Gln 
    450                 455                 460                 


Asn Gly Ala Gly Ala Ser Arg Thr Ser Thr Ile Phe Leu Asn Gly Asn 
465                 470                 475                 480 


Arg Glu Arg Pro Leu Asn Val Phe Cys Asp Met Glu Thr Asp Gly Gly 
                485                 490                 495     


Gly Trp Leu Val Phe Gln Arg Arg Met Asp Gly Gln Thr Asp Phe Trp 
            500                 505                 510         


Arg Asp Trp Glu Asp Tyr Ala His Gly Phe Gly Asn Ile Ser Gly Glu 
        515                 520                 525             


Phe Trp Leu Gly Asn Glu Ala Leu His Ser Leu Thr Gln Ala Gly Asp 
    530                 535                 540                 


Tyr Ser Met Arg Val Asp Leu Arg Ala Gly Asp Glu Ala Val Phe Ala 
545                 550                 555                 560 


Gln Tyr Asp Ser Phe His Val Asp Ser Ala Ala Glu Tyr Tyr Arg Leu 
                565                 570                 575     


His Leu Glu Gly Tyr His Gly Thr Ala Gly Asp Ser Met Ser Tyr His 
            580                 585                 590         


Ser Gly Ser Val Phe Ser Ala Arg Asp Arg Asp Pro Asn Ser Leu Leu 
        595                 600                 605             


Ile Ser Cys Ala Val Ser Tyr Arg Gly Ala Trp Trp Tyr Arg Asn Cys 
    610                 615                 620                 


His Tyr Ala Asn Leu Asn Gly Leu Tyr Gly Ser Thr Val Asp His Gln 
625                 630                 635                 640 


Gly Val Ser Trp Tyr His Trp Lys Gly Phe Glu Phe Ser Val Pro Phe 
                645                 650                 655     


Thr Glu Met Lys Leu Arg Pro Arg Asn Phe Arg Ser Pro Ala Gly Gly 
            660                 665                 670         


Gly 
    


<210>  1647
<211>  2622
<212>  DNA
<213>  Homosapiens

<400>  1647
aaccgtctcc tggttggggg gtggggggga aagatggcgg agctgatgct gctcagcgag     60

attgctgacc cgacgcgttt cttcaccgac aacctgctta gcccggagga ctggggtctg    120

cagaacagca ccttgtattc tggcctagat gaagtggccg aggagcagac gcagctcttc    180

cgttgcccgg agcaggatgt cccgtttgac ggcagctccc tggacgtggg gatggatgtc    240

agcccctctg agcccccatg ggaactcctg ccgatcttcc cagatcttca ggtgaagtct    300

gagccatctt ccccctgctc ttcctcctcc ctcagctccg agtcatcgcg tctctccaca    360

gagccatcca gcgaggctct tggggtaggg gaggtgctcc atgtgaagac agagtccttg    420

gcacccccac tgtgtctcct gggagatgac ccaacatcct catttgaaac cgtccagatc    480

aatgttatcc ccacctctga tgattcctca gatgtccaga ccaagataga acctgtctct    540

ccatgttctt ccgtcaactc tgaggcctcc ctgctctcag ccgactcctc cagccaggct    600

tttataggag aggaggtcct ggaagtgaag acagagtccc tgtccccttc aggatgcctc    660

ctgtgggatg tcccagcccc ctcacttgga gctgtccaga tcagcatggg cccatccctt    720

gatggctcct caggcaaagc cctgcccacc cggaagccgc cactgcagcc caaacctgta    780

gtgctaacca ctgtcccaat gccatccaga gctgtgcctc ccagcaccac agtccttctg    840

cagtccctcg tccagccacc cccagtgtcc ccagttgtcc tcatccaggg tgctattcga    900

gtccagcctg aagggccggc tccctctcta ccacggcctg agaggaagag catcgttccc    960

gctcctatgc ctggaaactc ctgcccgcct gaagtggatg caaagctgct gaagcggcag   1020

cagcgaatga tcaagaaccg ggagtcagcc tgccagtccc ggagaaagaa gaaagagtat   1080

ctgcagggac tggaggctcg gctgcaagca gtactggctg acaaccagca gctccgccga   1140

gagaatgctg ccctccggcg gcggctggag gccctgctgg ctgaaaacag cgagctcaag   1200

ttagggtctg gaaacaggaa ggtggtctgc atcatggtct tccttctctt cattgccttc   1260

aactttggac ctgtcagcat cagtgagcct ccttcagctc ccatctctcc tcggatgaac   1320

aagggggagc ctcaaccccg gagacacttg ctggggttct cagagcaaga gccagttcag   1380

ggagttgaac ctctccaggg gtcctcccag ggccctaagg agccccagcc cagccccaca   1440

gaccagccca gtttcagcaa cctgacagcc ttccctgggg gcgccaagga gctactacta   1500

agagacctag accagctctt cctctcctct gattgccggc acttcaaccg cactgagtcc   1560

ctgaggcttg ctgacgagtt gagtggctgg gtccagcgcc accagagagg ccggaggaag   1620

atccctcaga gggcccagga gagacagaag tctcagccac ggaagaagtc acctccagtt   1680

aaggcagtcc ccatccaacc ccctggaccc ccagaaaggg attctgtggg ccagctgcaa   1740

ctatatcgcc acccagaccg ttcgcagcca gcattcttgg atgcaattga ccgacgggaa   1800

gacacatttt atgttgtctc tttccgaagg gaccacctgc tgctcccagc catcagccac   1860

aacaagacct cccggcccaa gatgtccctg gtgatgcctg ccatggcccc caatgagacc   1920

ctgtcaggcc gtggggcccc gggggactat gaggagatga tgcagatcga gtgtgaggtc   1980

atggacacca gggtgattca catcaagacc tccacagtgc ccccctcgct ccgaaaacag   2040

ccatccccaa ccccaggcaa tgccacaggt ggccccttgc cagtctctgc agccagccag   2100

gcccaccagg cctcccacca gcccctctac ctcaatcatc cctgacctct gccattcaca   2160

ctgacttaga acggggggag ggggtaccag gtggccaggt gggactgttt caaatttccc   2220

tgatccccag gcttggggca attggtaaag gaaagagcag gtgtgggggt taagcactta   2280

tttgaggtgg gggtgttcac ctctcttctc atcccttttc agaatatagg gctcctctca   2340

ttcctgtgaa cccccagtcc tggcttcttt gtttgagggg attgtgtgag gttcagttgt   2400

ggggtgggtg gtgagctgct gcatattttt tattttgttt ctctagtgtt atggcagtgg   2460

aggtgggaat ttagtcccca ggtgggacaa gggaagtttt ttcattttgg agctagttac   2520

tgggagtaag ggagggtggg gtggggggga gttcaggttt atgtgtgtgc atttcttttt   2580

tattattatt aaataaacaa cttggaggga gttgaaaaaa aa                      2622


<210>  1648
<211>  703
<212>  PRT
<213>  Homosapiens

<400>  1648

Met Ala Glu Leu Met Leu Leu Ser Glu Ile Ala Asp Pro Thr Arg Phe 
1               5                   10                  15      


Phe Thr Asp Asn Leu Leu Ser Pro Glu Asp Trp Gly Leu Gln Asn Ser 
            20                  25                  30          


Thr Leu Tyr Ser Gly Leu Asp Glu Val Ala Glu Glu Gln Thr Gln Leu 
        35                  40                  45              


Phe Arg Cys Pro Glu Gln Asp Val Pro Phe Asp Gly Ser Ser Leu Asp 
    50                  55                  60                  


Val Gly Met Asp Val Ser Pro Ser Glu Pro Pro Trp Glu Leu Leu Pro 
65                  70                  75                  80  


Ile Phe Pro Asp Leu Gln Val Lys Ser Glu Pro Ser Ser Pro Cys Ser 
                85                  90                  95      


Ser Ser Ser Leu Ser Ser Glu Ser Ser Arg Leu Ser Thr Glu Pro Ser 
            100                 105                 110         


Ser Glu Ala Leu Gly Val Gly Glu Val Leu His Val Lys Thr Glu Ser 
        115                 120                 125             


Leu Ala Pro Pro Leu Cys Leu Leu Gly Asp Asp Pro Thr Ser Ser Phe 
    130                 135                 140                 


Glu Thr Val Gln Ile Asn Val Ile Pro Thr Ser Asp Asp Ser Ser Asp 
145                 150                 155                 160 


Val Gln Thr Lys Ile Glu Pro Val Ser Pro Cys Ser Ser Val Asn Ser 
                165                 170                 175     


Glu Ala Ser Leu Leu Ser Ala Asp Ser Ser Ser Gln Ala Phe Ile Gly 
            180                 185                 190         


Glu Glu Val Leu Glu Val Lys Thr Glu Ser Leu Ser Pro Ser Gly Cys 
        195                 200                 205             


Leu Leu Trp Asp Val Pro Ala Pro Ser Leu Gly Ala Val Gln Ile Ser 
    210                 215                 220                 


Met Gly Pro Ser Leu Asp Gly Ser Ser Gly Lys Ala Leu Pro Thr Arg 
225                 230                 235                 240 


Lys Pro Pro Leu Gln Pro Lys Pro Val Val Leu Thr Thr Val Pro Met 
                245                 250                 255     


Pro Ser Arg Ala Val Pro Pro Ser Thr Thr Val Leu Leu Gln Ser Leu 
            260                 265                 270         


Val Gln Pro Pro Pro Val Ser Pro Val Val Leu Ile Gln Gly Ala Ile 
        275                 280                 285             


Arg Val Gln Pro Glu Gly Pro Ala Pro Ser Leu Pro Arg Pro Glu Arg 
    290                 295                 300                 


Lys Ser Ile Val Pro Ala Pro Met Pro Gly Asn Ser Cys Pro Pro Glu 
305                 310                 315                 320 


Val Asp Ala Lys Leu Leu Lys Arg Gln Gln Arg Met Ile Lys Asn Arg 
                325                 330                 335     


Glu Ser Ala Cys Gln Ser Arg Arg Lys Lys Lys Glu Tyr Leu Gln Gly 
            340                 345                 350         


Leu Glu Ala Arg Leu Gln Ala Val Leu Ala Asp Asn Gln Gln Leu Arg 
        355                 360                 365             


Arg Glu Asn Ala Ala Leu Arg Arg Arg Leu Glu Ala Leu Leu Ala Glu 
    370                 375                 380                 


Asn Ser Glu Leu Lys Leu Gly Ser Gly Asn Arg Lys Val Val Cys Ile 
385                 390                 395                 400 


Met Val Phe Leu Leu Phe Ile Ala Phe Asn Phe Gly Pro Val Ser Ile 
                405                 410                 415     


Ser Glu Pro Pro Ser Ala Pro Ile Ser Pro Arg Met Asn Lys Gly Glu 
            420                 425                 430         


Pro Gln Pro Arg Arg His Leu Leu Gly Phe Ser Glu Gln Glu Pro Val 
        435                 440                 445             


Gln Gly Val Glu Pro Leu Gln Gly Ser Ser Gln Gly Pro Lys Glu Pro 
    450                 455                 460                 


Gln Pro Ser Pro Thr Asp Gln Pro Ser Phe Ser Asn Leu Thr Ala Phe 
465                 470                 475                 480 


Pro Gly Gly Ala Lys Glu Leu Leu Leu Arg Asp Leu Asp Gln Leu Phe 
                485                 490                 495     


Leu Ser Ser Asp Cys Arg His Phe Asn Arg Thr Glu Ser Leu Arg Leu 
            500                 505                 510         


Ala Asp Glu Leu Ser Gly Trp Val Gln Arg His Gln Arg Gly Arg Arg 
        515                 520                 525             


Lys Ile Pro Gln Arg Ala Gln Glu Arg Gln Lys Ser Gln Pro Arg Lys 
    530                 535                 540                 


Lys Ser Pro Pro Val Lys Ala Val Pro Ile Gln Pro Pro Gly Pro Pro 
545                 550                 555                 560 


Glu Arg Asp Ser Val Gly Gln Leu Gln Leu Tyr Arg His Pro Asp Arg 
                565                 570                 575     


Ser Gln Pro Ala Phe Leu Asp Ala Ile Asp Arg Arg Glu Asp Thr Phe 
            580                 585                 590         


Tyr Val Val Ser Phe Arg Arg Asp His Leu Leu Leu Pro Ala Ile Ser 
        595                 600                 605             


His Asn Lys Thr Ser Arg Pro Lys Met Ser Leu Val Met Pro Ala Met 
    610                 615                 620                 


Ala Pro Asn Glu Thr Leu Ser Gly Arg Gly Ala Pro Gly Asp Tyr Glu 
625                 630                 635                 640 


Glu Met Met Gln Ile Glu Cys Glu Val Met Asp Thr Arg Val Ile His 
                645                 650                 655     


Ile Lys Thr Ser Thr Val Pro Pro Ser Leu Arg Lys Gln Pro Ser Pro 
            660                 665                 670         


Thr Pro Gly Asn Ala Thr Gly Gly Pro Leu Pro Val Ser Ala Ala Ser 
        675                 680                 685             


Gln Ala His Gln Ala Ser His Gln Pro Leu Tyr Leu Asn His Pro 
    690                 695                 700             


<210>  1649
<211>  1357
<212>  DNA
<213>  Homosapiens

<400>  1649
gggttagttg tcagtatctt tcccagttgt tccgccccct acccccgcct cccgcaccgc     60

gcccctctcc ggctgccctc tccgcgtggg gcaaggctcc gagggcagca ttcagtagcc    120

atttagcttt ggaaggagag gtgattcgaa tggcccggct cctcctgtca ccatgctagg    180

cactttggcc gcgcaggtgc tgacctgaac ctggttcatc cctttctgac caaaactgtt    240

cactcaccgt ggaagggact aagcatccat atggagacgc caccagtcaa tacaattgga    300

gaaaaggaca cctctcagcc gcaacaagag tgggaaaaga accttcggga gaaccttgat    360

tcagttattc agattaggca gcagccccga gaccctccta ccgaaacgct tgagctggaa    420

gtaagcccag atccagccag ccaaattcta gagcatactc aaggagctga aaaactggtt    480

gctgaacttg aaggagactc tcataagtct catggatcaa ccagtcagat gccagaggcc    540

cttcaagctt ctgatctctg gtactgcccc gatgggagct ttgtcaagaa gatcgtaatc    600

cgtggccatg gcttggacaa acccaaacta ggctcctgct gccgggtact ggctttgggg    660

tttcctttcg gatcagggcc gccagagggc tggacagagc taactatggg cgtagggcca    720

tggagggagg aaacttgggg ggagctcata gagaaatgct tggagtccat gtgtcaaggt    780

gaggaagcag agcttcagct gcctgggcac tctggacctc ctgtcaggct cacactggca    840

tccttcactc aaggccgaga ctcctgggag ctggagacta gcgagaagga agccctggcc    900

agggaagaac gtgcaagggg cacagaacta tttcgagctg ggaaccctga aggagctgcc    960

cgatgctatg gacgggctct tcggctgctc ctgactttac ccccacctgg ccctccagaa   1020

cgaactgtcc ttcatgccaa tctggctgcc tgtcagttgt tgctagggca gcctcagttg   1080

gcagcccaga gctgtgaccg ggtgttggag cgggagcctg gccatttaaa ggccttatac   1140

cgaagggggg ttgcccaggc tgcccttggg aacctggaaa aagcaactgc tgacctcaag   1200

aaggtgctgg cgatagatcc caaaaaccgg gcagcccagg aggaactggg gaaggtggtc   1260

attcagggga agaaccagga tgcagggctg gctcagggtc tgcgcaagat gtttggctga   1320

ttaaaagtta aaccttaaaa gagaaaaaaa aaaaaaa                            1357


<210>  1650
<211>  349
<212>  PRT
<213>  Homosapiens

<400>  1650

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu 
        35                  40                  45              


Leu Glu Val Ser Pro Asp Pro Ala Ser Gln Ile Leu Glu His Thr Gln 
    50                  55                  60                  


Gly Ala Glu Lys Leu Val Ala Glu Leu Glu Gly Asp Ser His Lys Ser 
65                  70                  75                  80  


His Gly Ser Thr Ser Gln Met Pro Glu Ala Leu Gln Ala Ser Asp Leu 
                85                  90                  95      


Trp Tyr Cys Pro Asp Gly Ser Phe Val Lys Lys Ile Val Ile Arg Gly 
            100                 105                 110         


His Gly Leu Asp Lys Pro Lys Leu Gly Ser Cys Cys Arg Val Leu Ala 
        115                 120                 125             


Leu Gly Phe Pro Phe Gly Ser Gly Pro Pro Glu Gly Trp Thr Glu Leu 
    130                 135                 140                 


Thr Met Gly Val Gly Pro Trp Arg Glu Glu Thr Trp Gly Glu Leu Ile 
145                 150                 155                 160 


Glu Lys Cys Leu Glu Ser Met Cys Gln Gly Glu Glu Ala Glu Leu Gln 
                165                 170                 175     


Leu Pro Gly His Ser Gly Pro Pro Val Arg Leu Thr Leu Ala Ser Phe 
            180                 185                 190         


Thr Gln Gly Arg Asp Ser Trp Glu Leu Glu Thr Ser Glu Lys Glu Ala 
        195                 200                 205             


Leu Ala Arg Glu Glu Arg Ala Arg Gly Thr Glu Leu Phe Arg Ala Gly 
    210                 215                 220                 


Asn Pro Glu Gly Ala Ala Arg Cys Tyr Gly Arg Ala Leu Arg Leu Leu 
225                 230                 235                 240 


Leu Thr Leu Pro Pro Pro Gly Pro Pro Glu Arg Thr Val Leu His Ala 
                245                 250                 255     


Asn Leu Ala Ala Cys Gln Leu Leu Leu Gly Gln Pro Gln Leu Ala Ala 
            260                 265                 270         


Gln Ser Cys Asp Arg Val Leu Glu Arg Glu Pro Gly His Leu Lys Ala 
        275                 280                 285             


Leu Tyr Arg Arg Gly Val Ala Gln Ala Ala Leu Gly Asn Leu Glu Lys 
    290                 295                 300                 


Ala Thr Ala Asp Leu Lys Lys Val Leu Ala Ile Asp Pro Lys Asn Arg 
305                 310                 315                 320 


Ala Ala Gln Glu Glu Leu Gly Lys Val Val Ile Gln Gly Lys Asn Gln 
                325                 330                 335     


Asp Ala Gly Leu Ala Gln Gly Leu Arg Lys Met Phe Gly 
            340                 345                 


<210>  1651
<211>  1931
<212>  DNA
<213>  Homosapiens

<400>  1651
cttcatctct ccatctctgc gctgctgccg gctgcgccat ccagcaccca gactccagca     60

ccggccgagg acccccactc cggctgcagg gaccctgtcc cagcgagacc gcaggcatgt    120

catccgaaaa gtcaggactc ccagactcag tccctcacac ttctccgccg ccctacaatg    180

cccctcagcc tccagccgaa cccccagccc caccgccaca ggcagcccct tcctcacacc    240

atcaccacca ccaccactac catcagtctg gcaccgccac cctcccgcgc ttaggggcag    300

ggggcctggc ctcttccgcg gccaccgctc agcgcggtcc ctcctcctct gccacgctgc    360

cgaggccccc ccaccacgcc cctcccggcc ctgctgccgg ggcaccccca cccggctgcg    420

ctaccttgcc ccgcatgcca cccgaccctt acctgcagga gactcgcttc gagggcccac    480

ttcccccgcc gccgcccgct gccgccgccc cgcccccgcc ggcgccagcc cagactgccc    540

aggcccctgg cttcgtggtg cccacgcacg cggggactgt gggcacgctg ccgctggggg    600

gctacgtagc gcccggatac cccctgcagc tgcagccttg cactgcttac gtgccggtct    660

acccggtggg cacgccatat gcaggcggga ccccgggggg aacaggagtg acctccactc    720

tccccccgcc gccccagggc ccagggctgg ccctactgga gccgaggcgc ccgccacacg    780

actacatgcc catcgcggtg ctgaccacca tctgttgctt ctggcctact ggcatcattg    840

ccatcttcaa ggccgtgcag gtgcgcacgg ccttggcccg cggagacatg gtgtcggccg    900

agatcgcttc acgcgaggcc cggaacttct ccttcatctc cctggccgtg ggcatcgcgg    960

ccatggtgct ctgtaccatc ctcaccgtag tcatcatcat cgccgcgcag caccacgaga   1020

actactggga tccctaaaaa cgcccctggt ccggccccac tctgcgcccc tcgatctccc   1080

aggctctttc tgcagtcata ccgcggaccc aatgggcgcc ctgcacaccc gtttctgggg   1140

ccgtcagact tggatacatc gtaaactccg cctccacgga acgtctcgcc ttgcgagcaa   1200

gctcggaatc cagttcctca ggaacccctc caaaacccac acccccaggg acgccgcttt   1260

ccgggatccc ggccaaacgc cggaccctca gtcgctccag gccccctcac cctcaaagtg   1320

tagcgccccc aaccgagcaa cctcggtttg gtccctaaaa ccccgcctcc tctataagca   1380

ccgccccagc tctgacaaaa ccccgcctcc aggtcggcag gctccgcctt cttttcttct   1440

ccgcggggtg attcagtcca gtgattgggt ttgtggctcc aggcctcgcc cacagacgga   1500

cagacccctc cctttcttcc ggcaaaagga ccgagccctg gggtagtaag gcccccacac   1560

tcctgttttt tgcaagtaca tttttgtccc tcctccaccc aggtatctgc ctattttctt   1620

gctaatccca gaacctttcc ttttgctttt tttaaggaca tttgggaagt tcctggtgta   1680

ggacccttct ccctgggata agaaacctgc ctgtaaacgc tctgtaaata ctcccttcca   1740

cccatcccag cccctgggca gccgggcaga agggaatcca ggctatggac ctcccaagtc   1800

cccgctcccc gctcccctcg gcggccccgc cttgttctga tctgtgtgtg agtgtgtgtg   1860

aacttctgaa agacaatatt aaagagactt agttgaaaaa aaaaaaaaaa aaaaaaaaaa   1920

aaaaaaaaaa a                                                        1931


<210>  1652
<211>  306
<212>  PRT
<213>  Homosapiens

<400>  1652

Met Ser Ser Glu Lys Ser Gly Leu Pro Asp Ser Val Pro His Thr Ser 
1               5                   10                  15      


Pro Pro Pro Tyr Asn Ala Pro Gln Pro Pro Ala Glu Pro Pro Ala Pro 
            20                  25                  30          


Pro Pro Gln Ala Ala Pro Ser Ser His His His His His His His Tyr 
        35                  40                  45              


His Gln Ser Gly Thr Ala Thr Leu Pro Arg Leu Gly Ala Gly Gly Leu 
    50                  55                  60                  


Ala Ser Ser Ala Ala Thr Ala Gln Arg Gly Pro Ser Ser Ser Ala Thr 
65                  70                  75                  80  


Leu Pro Arg Pro Pro His His Ala Pro Pro Gly Pro Ala Ala Gly Ala 
                85                  90                  95      


Pro Pro Pro Gly Cys Ala Thr Leu Pro Arg Met Pro Pro Asp Pro Tyr 
            100                 105                 110         


Leu Gln Glu Thr Arg Phe Glu Gly Pro Leu Pro Pro Pro Pro Pro Ala 
        115                 120                 125             


Ala Ala Ala Pro Pro Pro Pro Ala Pro Ala Gln Thr Ala Gln Ala Pro 
    130                 135                 140                 


Gly Phe Val Val Pro Thr His Ala Gly Thr Val Gly Thr Leu Pro Leu 
145                 150                 155                 160 


Gly Gly Tyr Val Ala Pro Gly Tyr Pro Leu Gln Leu Gln Pro Cys Thr 
                165                 170                 175     


Ala Tyr Val Pro Val Tyr Pro Val Gly Thr Pro Tyr Ala Gly Gly Thr 
            180                 185                 190         


Pro Gly Gly Thr Gly Val Thr Ser Thr Leu Pro Pro Pro Pro Gln Gly 
        195                 200                 205             


Pro Gly Leu Ala Leu Leu Glu Pro Arg Arg Pro Pro His Asp Tyr Met 
    210                 215                 220                 


Pro Ile Ala Val Leu Thr Thr Ile Cys Cys Phe Trp Pro Thr Gly Ile 
225                 230                 235                 240 


Ile Ala Ile Phe Lys Ala Val Gln Val Arg Thr Ala Leu Ala Arg Gly 
                245                 250                 255     


Asp Met Val Ser Ala Glu Ile Ala Ser Arg Glu Ala Arg Asn Phe Ser 
            260                 265                 270         


Phe Ile Ser Leu Ala Val Gly Ile Ala Ala Met Val Leu Cys Thr Ile 
        275                 280                 285             


Leu Thr Val Val Ile Ile Ile Ala Ala Gln His His Glu Asn Tyr Trp 
    290                 295                 300                 


Asp Pro 
305     


<210>  1653
<211>  2202
<212>  DNA
<213>  Homosapiens

<400>  1653
ggaagtgggg agaatcaagg cggggaaatc ggactttcgg gtcgctgggg gcaacgaagc     60

ctggagaggc cttctttcca ttcccagaat atgtttgctg ctttttcctc tccccactgg    120

cctaaatgga tcgctccgcc tgtttcctcc ccagcaccta gggcgcaatg gaatattcca    180

ttgcccctcc tgtcctgggt ctgtgttgcg gggaacgctc gcgcggttgc cagagaaagc    240

cccggacgtg acggatttgc gcgaccccaa gcagcccgcc cttccccctc ccatccgtca    300

ttcccctgcg ttctctttcc tcacccttcc ccccgccacc gtgggttcca gacttgggat    360

aagtaaacag cgggtggagc gaggcctacg gacccaggcc aggtgggagt ctgcactctt    420

caaggggcct gggctgctgc tcacgggtat taaagaactc cgcgttgttc atggctgagg    480

cgatgcatta ggaagatcct ggacctagag aacaagtccc ccgaacgctg agttggaggc    540

gggacttcgg gtgcgcgttg gcgggagcat gctggggctc tgggggcagc ggctccccgc    600

ggcgtgggtc ctgcttctgt tgcctttcct gccgctgctg ctgcttgcag cccccgcgcc    660

ccaccgcgcg tcctacaagc cggtcatcgt ggtgcatggg ctcttcgaca gctcgtacag    720

cttccgccac ctgctggaat acatcaatga gacacacccc gggactgtgg tgacagtgct    780

cgatctcttc gatgggagag agagcttgcg acccctgtgg gaacaggtgc aagggttccg    840

agaggctgtg gtccccatca tggcaaaggc ccctcaaggg gtgcatctca tctgctactc    900

gcaggggggc cttgtgtgcc gggctctgct ttctgtcatg gatgatcaca acgtggattc    960

tttcatctcc ctctcctctc cacagatggg acagtatgga gacacggact acttgaagtg   1020

gctgttcccc acctccatgc ggtctaacct ctatcggatc tgctatagcc cctggggcca   1080

ggaattctcc atctgcaact actggcatga tccccaccac gatgacttgt acctcaatgc   1140

cagcagcttc ctggccctga tcaatgggga aagagaccat cccaatgcca cagtatggcg   1200

gaagaacttt ctgcgtgtgg gccacctggt gctgattggg ggccctgatg atggtgttat   1260

tactccctgg cagtccagct tctttggttt ctatgatgca aatgagaccg tcctggagat   1320

ggaggagcaa ctggtttatc tgcgggattc ttttgggttg aagactctat tggcccgggg   1380

ggccatagtg aggtgtccaa tggccggtat ctcccacaca gcctggcact ccaaccgtac   1440

cctttatgag acctgcattg aaccttggct ctcctgagga tatattcagg ggtccccagg   1500

aactcctcgg tccagagacc aagtggtggc cttggaaagc agatgtcagg ctttggtgtg   1560

cctgtgacca cctcattgct cccatattat cccccatttt tagtagagac ggggttttag   1620

tagagacttg gcctcccaga acccccttcc tctgctcctc catgaatgac aattccaggc   1680

ctcccctacc tcatgtcctc tcatttgggg gattgctccg tgctgtccct ttctctcaag   1740

gccgaagttg ggaagtgaga aaccatgttt ttaacttgtg gctgcttttg ctgctgctgc   1800

tcctccgtat ctggctgtat gggtggagaa cccaccccct gcccaccaca ggggtctcct   1860

tccaggccac tcaggacatt tttagcttct ctcctcccca tgttcccttt tttctctaaa   1920

gtcccctgac atcagccctc ccaactccta agagggacta cccatgagag tggggttctg   1980

aggctcccct atggggacag ttccgttctt gaagtgtcag tgttggggaa tatctgtggc   2040

ctatgaggcc catctcaggt ttggggatcc cccagtccct atgatcagtg ttggagtacc   2100

cccctgggag agcctagttt ctttgaggcc ccaggccctc ttttaactac ctttgaatag   2160

gtgttatccc tgtatttatg gaaataaagt tccatttcct ca                      2202


<210>  1654
<211>  302
<212>  PRT
<213>  Homosapiens

<400>  1654

Met Leu Gly Leu Trp Gly Gln Arg Leu Pro Ala Ala Trp Val Leu Leu 
1               5                   10                  15      


Leu Leu Pro Phe Leu Pro Leu Leu Leu Leu Ala Ala Pro Ala Pro His 
            20                  25                  30          


Arg Ala Ser Tyr Lys Pro Val Ile Val Val His Gly Leu Phe Asp Ser 
        35                  40                  45              


Ser Tyr Ser Phe Arg His Leu Leu Glu Tyr Ile Asn Glu Thr His Pro 
    50                  55                  60                  


Gly Thr Val Val Thr Val Leu Asp Leu Phe Asp Gly Arg Glu Ser Leu 
65                  70                  75                  80  


Arg Pro Leu Trp Glu Gln Val Gln Gly Phe Arg Glu Ala Val Val Pro 
                85                  90                  95      


Ile Met Ala Lys Ala Pro Gln Gly Val His Leu Ile Cys Tyr Ser Gln 
            100                 105                 110         


Gly Gly Leu Val Cys Arg Ala Leu Leu Ser Val Met Asp Asp His Asn 
        115                 120                 125             


Val Asp Ser Phe Ile Ser Leu Ser Ser Pro Gln Met Gly Gln Tyr Gly 
    130                 135                 140                 


Asp Thr Asp Tyr Leu Lys Trp Leu Phe Pro Thr Ser Met Arg Ser Asn 
145                 150                 155                 160 


Leu Tyr Arg Ile Cys Tyr Ser Pro Trp Gly Gln Glu Phe Ser Ile Cys 
                165                 170                 175     


Asn Tyr Trp His Asp Pro His His Asp Asp Leu Tyr Leu Asn Ala Ser 
            180                 185                 190         


Ser Phe Leu Ala Leu Ile Asn Gly Glu Arg Asp His Pro Asn Ala Thr 
        195                 200                 205             


Val Trp Arg Lys Asn Phe Leu Arg Val Gly His Leu Val Leu Ile Gly 
    210                 215                 220                 


Gly Pro Asp Asp Gly Val Ile Thr Pro Trp Gln Ser Ser Phe Phe Gly 
225                 230                 235                 240 


Phe Tyr Asp Ala Asn Glu Thr Val Leu Glu Met Glu Glu Gln Leu Val 
                245                 250                 255     


Tyr Leu Arg Asp Ser Phe Gly Leu Lys Thr Leu Leu Ala Arg Gly Ala 
            260                 265                 270         


Ile Val Arg Cys Pro Met Ala Gly Ile Ser His Thr Ala Trp His Ser 
        275                 280                 285             


Asn Arg Thr Leu Tyr Glu Thr Cys Ile Glu Pro Trp Leu Ser 
    290                 295                 300         


<210>  1655
<211>  1772
<212>  DNA
<213>  Homosapiens

<400>  1655
gagtagagta gggcaggaga aactgggcca ggctgcactt agctcaaggg gcctcgagga     60

ctctctgcgt ctctggagac aagggcacta cacgcacttc agaatgaaga gttgcgggag    120

catgctgggg ctctgggggc agcggctccc cgcggcgtgg gtcctgcttc tgttgccttt    180

cctgccgctg ctgctgcttg cagcccccgc gccccaccgc gcgtcctaca agccggtcat    240

cgtggtgcat gggctcttcg acagctcgta cagcttccgc cacctgctgg aatacatcaa    300

tgagacacac cccgggactg tggtgacagt gctcgatctc ttcgatggga gagagagctt    360

gcgacccctg tgggaacagg tgcaagggtt ccgagaggct gtggtcccca tcatggcaaa    420

ggcccctcaa ggggtgcatc tcatctgcta ctcgcagggg ggccttgtgt gccgggctct    480

gctttctgtc atggatgatc acaacgtgga ttctttcatc tccctctcct ctccacagat    540

gggacagtat ggagacacgg actacttgaa gtggctgttc cccacctcca tgcggtctaa    600

cctctatcgg atctgctata gcccctgggg ccaggaattc tccatctgca actactggca    660

tgatccccac cacgatgact tgtacctcaa tgccagcagc ttcctggccc tgatcaatgg    720

ggaaagagac catcccaatg ccacagtatg gcggaagaac tttctgcgtg tgggccacct    780

ggtgctgatt gggggccctg atgatggtgt tattactccc tggcagtcca gcttctttgg    840

tttctatgat gcaaatgaga ccgtcctgga gatggaggag caactggttt atctgcggga    900

ttcttttggg ttgaagactc tattggcccg gggggccata gtgaggtgtc caatggccgg    960

tatctcccac acagcctggc actccaaccg taccctttat gagacctgca ttgaaccttg   1020

gctctcctga ggatatattc aggggtcccc aggaactcct cggtccagag accaagtggt   1080

ggccttggaa agcagatgtc aggctttggt gtgcctgtga ccacctcatt gctcccatat   1140

tatcccccat ttttagtaga gacggggttt tagtagagac ttggcctccc agaaccccct   1200

tcctctgctc ctccatgaat gacaattcca ggcctcccct acctcatgtc ctctcatttg   1260

ggggattgct ccgtgctgtc cctttctctc aaggccgaag ttgggaagtg agaaaccatg   1320

tttttaactt gtggctgctt ttgctgctgc tgctcctccg tatctggctg tatgggtgga   1380

gaacccaccc cctgcccacc acaggggtct ccttccaggc cactcaggac atttttagct   1440

tctctcctcc ccatgttccc ttttttctct aaagtcccct gacatcagcc ctcccaactc   1500

ctaagaggga ctacccatga gagtggggtt ctgaggctcc cctatgggga cagttccgtt   1560

cttgaagtgt cagtgttggg gaatatctgt ggcctatgag gcccatctca ggtttgggga   1620

tcccccagtc cctatgatca gtgttggagt acccccctgg gagagcctag tttctttgag   1680

gccccaggcc ctcttttaac tacctttgaa taggtgttat ccctgtattt atggaaataa   1740

agttccattt cctcaaaaaa aaaaaaaaaa aa                                 1772


<210>  1656
<211>  308
<212>  PRT
<213>  Homosapiens

<400>  1656

Met Lys Ser Cys Gly Ser Met Leu Gly Leu Trp Gly Gln Arg Leu Pro 
1               5                   10                  15      


Ala Ala Trp Val Leu Leu Leu Leu Pro Phe Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Ala Ala Pro Ala Pro His Arg Ala Ser Tyr Lys Pro Val Ile Val Val 
        35                  40                  45              


His Gly Leu Phe Asp Ser Ser Tyr Ser Phe Arg His Leu Leu Glu Tyr 
    50                  55                  60                  


Ile Asn Glu Thr His Pro Gly Thr Val Val Thr Val Leu Asp Leu Phe 
65                  70                  75                  80  


Asp Gly Arg Glu Ser Leu Arg Pro Leu Trp Glu Gln Val Gln Gly Phe 
                85                  90                  95      


Arg Glu Ala Val Val Pro Ile Met Ala Lys Ala Pro Gln Gly Val His 
            100                 105                 110         


Leu Ile Cys Tyr Ser Gln Gly Gly Leu Val Cys Arg Ala Leu Leu Ser 
        115                 120                 125             


Val Met Asp Asp His Asn Val Asp Ser Phe Ile Ser Leu Ser Ser Pro 
    130                 135                 140                 


Gln Met Gly Gln Tyr Gly Asp Thr Asp Tyr Leu Lys Trp Leu Phe Pro 
145                 150                 155                 160 


Thr Ser Met Arg Ser Asn Leu Tyr Arg Ile Cys Tyr Ser Pro Trp Gly 
                165                 170                 175     


Gln Glu Phe Ser Ile Cys Asn Tyr Trp His Asp Pro His His Asp Asp 
            180                 185                 190         


Leu Tyr Leu Asn Ala Ser Ser Phe Leu Ala Leu Ile Asn Gly Glu Arg 
        195                 200                 205             


Asp His Pro Asn Ala Thr Val Trp Arg Lys Asn Phe Leu Arg Val Gly 
    210                 215                 220                 


His Leu Val Leu Ile Gly Gly Pro Asp Asp Gly Val Ile Thr Pro Trp 
225                 230                 235                 240 


Gln Ser Ser Phe Phe Gly Phe Tyr Asp Ala Asn Glu Thr Val Leu Glu 
                245                 250                 255     


Met Glu Glu Gln Leu Val Tyr Leu Arg Asp Ser Phe Gly Leu Lys Thr 
            260                 265                 270         


Leu Leu Ala Arg Gly Ala Ile Val Arg Cys Pro Met Ala Gly Ile Ser 
        275                 280                 285             


His Thr Ala Trp His Ser Asn Arg Thr Leu Tyr Glu Thr Cys Ile Glu 
    290                 295                 300                 


Pro Trp Leu Ser 
305             


<210>  1657
<211>  1293
<212>  DNA
<213>  Homosapiens

<400>  1657
gcttgaagcc tcccaggaga aagaagccag cctgtagggt ccagcgtcaa agcgaatcat     60

ggggtccagg gctgagctgt gcactctctt aggcggattc tccttcctcc tgctactgat    120

accaggcgag ggggccaagg gtggatccct cagagagagt cagggagtct gctccaagca    180

gacactggtg gtcccgctcc actacaacga gtcctacagc caaccagtgt acaagcccta    240

cctgaccttg tgcgctggga ggcgcatctg cagcacttac aggaccatgt accgcgttat    300

gtggcgggag gtgaggcggg aggttcagca gacccatgca gtgtgctgcc agggctggaa    360

gaagcggcac ccgggggcgc tcacctgtga agccatctgc gccaagcctt gcctgaacgg    420

aggcgtctgc gttaggcctg accagtgcga gtgcgccccc ggctggggag ggaagcactg    480

tcatgtggac gtggatgaat gtaggaccag catcaccctc tgctcgcacc attgttttaa    540

tacggcaggc agcttcacct gcggctgccc ccatgaccta gtgctaggcg tggacgggcg    600

cacctgcatg gaggggtccc cagagccccc aaccagtgcc agcatactca gcgtggccgt    660

tcgggaggcg gaaaaagatg agcgcgctct gaagcaggag attcacgagc tgcgagggcg    720

cctggagcgg ctggagcagt gggccggtca ggctggggcc tgggtcagag cggtgctgcc    780

cgtgccgcct gaagagctgc agccagaaca ggtggctgag ctgtggggcc ggggtgaccg    840

gatcgaatct ctcagcgacc aggtgctgct gctggaggag aggctaggtg cctgctcctg    900

tgaggacaac agcctgggcc tcggcgtcaa tcatcgataa gaagcctcta cagcacccct    960

gccccctaat ttatacagaa accggaccca ctaatcctct gggattggcc gactgtgagc   1020

tgcagataag gctatcagcc accaaagagc aatgaacaat ggaaacttca gagagctgaa   1080

gaaaggggga ggcctgtgtt cttggcctgc ccctgagtct tctggctggg ggcaggttgc   1140

ctgggcaaga actgcttctt caattcctta acaaatgcaa ccaccaacac ccagatctct   1200

ctctctcttt attttcagtt tttttgctgt tatccagata attaataaaa accaaccacg   1260

caaaactgga aaaaaaaaaa aaaaaaaact cga                                1293


<210>  1658
<211>  293
<212>  PRT
<213>  Homosapiens

<400>  1658

Met Gly Ser Arg Ala Glu Leu Cys Thr Leu Leu Gly Gly Phe Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Ile Pro Gly Glu Gly Ala Lys Gly Gly Ser Leu Arg 
            20                  25                  30          


Glu Ser Gln Gly Val Cys Ser Lys Gln Thr Leu Val Val Pro Leu His 
        35                  40                  45              


Tyr Asn Glu Ser Tyr Ser Gln Pro Val Tyr Lys Pro Tyr Leu Thr Leu 
    50                  55                  60                  


Cys Ala Gly Arg Arg Ile Cys Ser Thr Tyr Arg Thr Met Tyr Arg Val 
65                  70                  75                  80  


Met Trp Arg Glu Val Arg Arg Glu Val Gln Gln Thr His Ala Val Cys 
                85                  90                  95      


Cys Gln Gly Trp Lys Lys Arg His Pro Gly Ala Leu Thr Cys Glu Ala 
            100                 105                 110         


Ile Cys Ala Lys Pro Cys Leu Asn Gly Gly Val Cys Val Arg Pro Asp 
        115                 120                 125             


Gln Cys Glu Cys Ala Pro Gly Trp Gly Gly Lys His Cys His Val Asp 
    130                 135                 140                 


Val Asp Glu Cys Arg Thr Ser Ile Thr Leu Cys Ser His His Cys Phe 
145                 150                 155                 160 


Asn Thr Ala Gly Ser Phe Thr Cys Gly Cys Pro His Asp Leu Val Leu 
                165                 170                 175     


Gly Val Asp Gly Arg Thr Cys Met Glu Gly Ser Pro Glu Pro Pro Thr 
            180                 185                 190         


Ser Ala Ser Ile Leu Ser Val Ala Val Arg Glu Ala Glu Lys Asp Glu 
        195                 200                 205             


Arg Ala Leu Lys Gln Glu Ile His Glu Leu Arg Gly Arg Leu Glu Arg 
    210                 215                 220                 


Leu Glu Gln Trp Ala Gly Gln Ala Gly Ala Trp Val Arg Ala Val Leu 
225                 230                 235                 240 


Pro Val Pro Pro Glu Glu Leu Gln Pro Glu Gln Val Ala Glu Leu Trp 
                245                 250                 255     


Gly Arg Gly Asp Arg Ile Glu Ser Leu Ser Asp Gln Val Leu Leu Leu 
            260                 265                 270         


Glu Glu Arg Leu Gly Ala Cys Ser Cys Glu Asp Asn Ser Leu Gly Leu 
        275                 280                 285             


Gly Val Asn His Arg 
    290             


<210>  1659
<211>  2242
<212>  DNA
<213>  Homosapiens

<400>  1659
ggaaaccagc aggcgttggg gaggggtggc gggggaatag cggcggcagc agccccagcc     60

ctcagagaga cagcagaaag ggagggaggg agggtgctgg ggggacagcc ccccaccatt    120

cctaccgcta tgggcccaac ctcccactcc cacctcccct ccatcggccg gggctaggac    180

acccccaaat cccgtcgccc ccttggcacc gacaccccga cagagacaga gacacagcca    240

tccgccacca ccgctgccgc agcctggctg gggagggggc cagcccccca ggccccctac    300

ccctctgagg tggccagaat ggatttgtgg ccaggggcat ggatgctgct gctgctgctc    360

ttcctgctgc tgctcttcct gctgcccacc ctgtggttct gcagccccag tgccaagtac    420

ttcttcaaga tggccttcta caatggctgg atcctcttcc tggctgtgct cgccatccct    480

gtgtgtgccg tgcgaggacg caacgtcgag aacatgaaga tcttgcgtct aatgctgctc    540

cacatcaaat acctgtacgg gatccgagtg gaggtgcgag gggctcacca cttccctccc    600

tcgcagccct atgttgttgt ctccaaccac cagagctctc tcgatctgct tgggatgatg    660

gaggtactgc caggccgctg tgtgcccatt gccaagcgcg agctactgtg ggctggctct    720

gccgggctgg cctgctggct ggcaggagtc atcttcatcg accggaagcg cacgggggat    780

gccatcagtg tcatgtctga ggtcgcccag accctgctca cccaggacgt gagggtctgg    840

gtgtttcctg agggaacgag aaaccacaat ggctccatgc tgcccttcaa acgtggcgcc    900

ttccatcttg cagtgcaggc ccaggttccc attgtcccca tagtcatgtc ctcctaccaa    960

gacttctact gcaagaagga gcgtcgcttc acctcgggac aatgtcaggt gcgggtgctg   1020

cccccagtgc ccacggaagg gctgacacca gatgacgtcc cagctctggc tgacagagtc   1080

cggcactcca tgctcactgt tttccgggaa atctccactg atggccgggg tggtggtgac   1140

tatctgaaga agcctggggg cggtgggtga accctggctc tgagctctcc tcccatctgt   1200

ccccatcttc ctccccacac ctacccaccc agtgggccct gaagcagggc caaaccctct   1260

tccttgtctc ccctctcccc acttattctc ctatttggaa tcttcaactt ctgaagtgaa   1320

tgtggataca gcgccactcc tgccccctct tggccccatc catggactct tgcctcggtg   1380

cagtctccac tcttgacccc cacctcctac tgtcttgtct gtgggacagt tgcctccccc   1440

tcatctccag tgactcagcc tacacaaggg aggggaacat tccatcccca gtggagtctc   1500

ttcctatgtg gtcttctcta cccctctacc ccacattggc cagtggactc atccattctt   1560

tggaacaaat cccccccact ccaaagtcca tggattcaat ggactcatcc atttgtgagg   1620

aggacttctc gccctctggc tggaagctga tacctgaagc actcccaggc tcatcctggg   1680

agctttcctc agcaccttca ccttccctcc cagtgtagcc tcctgtcagt gggggctgga   1740

cccttctaat tcagaggtct catgcctgcc cttgcccaga tgcccagggt cgtgcactct   1800

ctgggatacc agttcagtct ccacatttct ggttttctgt ccccatagta cagttcttca   1860

gtggacatga ccccacccag ccccctgcag ccctgctgca ccatctcacc agacacaagg   1920

ggaagaagca gacatcaggt gctgcactca cttctgcccc ctggggagtt ggggaaagga   1980

acgaaccctg gctggagggg ataggagggc ttttaattta tttctttttc tgttgaggct   2040

tccccctctc tgagccagtt ttcatttctt cctggtggca ttagccactc cctgcctctc   2100

actccagacc tgttcccaca actggggagg taggctggga gcaaaaggag agggtgggac   2160

ccagttttgc gtggttggtt tttattaatt atctggataa cagcaaaaaa actgaaaata   2220

aagagagaga gagaaaaaaa aa                                            2242


<210>  1660
<211>  283
<212>  PRT
<213>  Homosapiens

<400>  1660

Met Asp Leu Trp Pro Gly Ala Trp Met Leu Leu Leu Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Leu Pro Thr Leu Trp Phe Cys Ser Pro Ser Ala 
            20                  25                  30          


Lys Tyr Phe Phe Lys Met Ala Phe Tyr Asn Gly Trp Ile Leu Phe Leu 
        35                  40                  45              


Ala Val Leu Ala Ile Pro Val Cys Ala Val Arg Gly Arg Asn Val Glu 
    50                  55                  60                  


Asn Met Lys Ile Leu Arg Leu Met Leu Leu His Ile Lys Tyr Leu Tyr 
65                  70                  75                  80  


Gly Ile Arg Val Glu Val Arg Gly Ala His His Phe Pro Pro Ser Gln 
                85                  90                  95      


Pro Tyr Val Val Val Ser Asn His Gln Ser Ser Leu Asp Leu Leu Gly 
            100                 105                 110         


Met Met Glu Val Leu Pro Gly Arg Cys Val Pro Ile Ala Lys Arg Glu 
        115                 120                 125             


Leu Leu Trp Ala Gly Ser Ala Gly Leu Ala Cys Trp Leu Ala Gly Val 
    130                 135                 140                 


Ile Phe Ile Asp Arg Lys Arg Thr Gly Asp Ala Ile Ser Val Met Ser 
145                 150                 155                 160 


Glu Val Ala Gln Thr Leu Leu Thr Gln Asp Val Arg Val Trp Val Phe 
                165                 170                 175     


Pro Glu Gly Thr Arg Asn His Asn Gly Ser Met Leu Pro Phe Lys Arg 
            180                 185                 190         


Gly Ala Phe His Leu Ala Val Gln Ala Gln Val Pro Ile Val Pro Ile 
        195                 200                 205             


Val Met Ser Ser Tyr Gln Asp Phe Tyr Cys Lys Lys Glu Arg Arg Phe 
    210                 215                 220                 


Thr Ser Gly Gln Cys Gln Val Arg Val Leu Pro Pro Val Pro Thr Glu 
225                 230                 235                 240 


Gly Leu Thr Pro Asp Asp Val Pro Ala Leu Ala Asp Arg Val Arg His 
                245                 250                 255     


Ser Met Leu Thr Val Phe Arg Glu Ile Ser Thr Asp Gly Arg Gly Gly 
            260                 265                 270         


Gly Asp Tyr Leu Lys Lys Pro Gly Gly Gly Gly 
        275                 280             


<210>  1661
<211>  2023
<212>  DNA
<213>  Homosapiens

<400>  1661
ggactttgga gcgtatggct ccaaatcaac tcattggcta aaacttgacg gaaaatggtg     60

gttaggtggc cagaatggat ttgtggccag gggcatggat gctgctgctg ctgctcttcc    120

tgctgctgct cttcctgctg cccaccctgt ggttctgcag ccccagtgcc aagtacttct    180

tcaagatggc cttctacaat ggctggatcc tcttcctggc tgtgctcgcc atccctgtgt    240

gtgccgtgcg aggacgcaac gtcgagaaca tgaagatctt gcgtctaatg ctgctccaca    300

tcaaatacct gtacgggatc cgagtggagg tgcgaggggc tcaccacttc cctccctcgc    360

agccctatgt tgttgtctcc aaccaccaga gctctctcga tctgcttggg atgatggagg    420

tactgccagg ccgctgtgtg cccattgcca agcgcgagct actgtgggct ggctctgccg    480

ggctggcctg ctggctggca ggagtcatct tcatcgaccg gaagcgcacg ggggatgcca    540

tcagtgtcat gtctgaggtc gcccagaccc tgctcaccca ggacgtgagg gtctgggtgt    600

ttcctgaggg aacgagaaac cacaatggct ccatgctgcc cttcaaacgt ggcgccttcc    660

atcttgcagt gcaggcccag gttcccattg tccccatagt catgtcctcc taccaagact    720

tctactgcaa gaaggagcgt cgcttcacct cgggacaatg tcaggtgcgg gtgctgcccc    780

cagtgcccac ggaagggctg acaccagatg acgtcccagc tctggctgac agagtccggc    840

actccatgct cactgttttc cgggaaatct ccactgatgg ccggggtggt ggtgactatc    900

tgaagaagcc tgggggcggt gggtgaaccc tggctctgag ctctcctccc atctgtcccc    960

atcttcctcc ccacacctac ccacccagtg ggccctgaag cagggccaaa ccctcttcct   1020

tgtctcccct ctccccactt attctcctat ttggaatctt caacttctga agtgaatgtg   1080

gatacagcgc cactcctgcc ccctcttggc cccatccatg gactcttgcc tcggtgcagt   1140

ctccactctt gacccccacc tcctactgtc ttgtctgtgg gacagttgcc tccccctcat   1200

ctccagtgac tcagcctaca caagggaggg gaacattcca tccccagtgg agtctcttcc   1260

tatgtggtct tctctacccc tctaccccac attggccagt ggactcatcc attctttgga   1320

acaaatcccc cccactccaa agtccatgga ttcaatggac tcatccattt gtgaggagga   1380

cttctcgccc tctggctgga agctgatacc tgaagcactc ccaggctcat cctgggagct   1440

ttcctcagca ccttcacctt ccctcccagt gtagcctcct gtcagtgggg gctggaccct   1500

tctaattcag aggtctcatg cctgcccttg cccagatgcc cagggtcgtg cactctctgg   1560

gataccagtt cagtctccac atttctggtt ttctgtcccc atagtacagt tcttcagtgg   1620

acatgacccc acccagcccc ctgcagccct gctgcaccat ctcaccagac acaaggggaa   1680

gaagcagaca tcaggtgctg cactcacttc tgccccctgg ggagttgggg aaaggaacga   1740

accctggctg gaggggatag gagggctttt aatttatttc tttttctgtt gaggcttccc   1800

cctctctgag ccagttttca tttcttcctg gtggcattag ccactccctg cctctcactc   1860

cagacctgtt cccacaactg gggaggtagg ctgggagcaa aaggagaggg tgggacccag   1920

ttttgcgtgg ttggttttta ttaattatct ggataacagc aaaaaaactg aaaataaaga   1980

gagagagaga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                     2023


<210>  1662
<211>  283
<212>  PRT
<213>  Homosapiens

<400>  1662

Met Asp Leu Trp Pro Gly Ala Trp Met Leu Leu Leu Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Leu Pro Thr Leu Trp Phe Cys Ser Pro Ser Ala 
            20                  25                  30          


Lys Tyr Phe Phe Lys Met Ala Phe Tyr Asn Gly Trp Ile Leu Phe Leu 
        35                  40                  45              


Ala Val Leu Ala Ile Pro Val Cys Ala Val Arg Gly Arg Asn Val Glu 
    50                  55                  60                  


Asn Met Lys Ile Leu Arg Leu Met Leu Leu His Ile Lys Tyr Leu Tyr 
65                  70                  75                  80  


Gly Ile Arg Val Glu Val Arg Gly Ala His His Phe Pro Pro Ser Gln 
                85                  90                  95      


Pro Tyr Val Val Val Ser Asn His Gln Ser Ser Leu Asp Leu Leu Gly 
            100                 105                 110         


Met Met Glu Val Leu Pro Gly Arg Cys Val Pro Ile Ala Lys Arg Glu 
        115                 120                 125             


Leu Leu Trp Ala Gly Ser Ala Gly Leu Ala Cys Trp Leu Ala Gly Val 
    130                 135                 140                 


Ile Phe Ile Asp Arg Lys Arg Thr Gly Asp Ala Ile Ser Val Met Ser 
145                 150                 155                 160 


Glu Val Ala Gln Thr Leu Leu Thr Gln Asp Val Arg Val Trp Val Phe 
                165                 170                 175     


Pro Glu Gly Thr Arg Asn His Asn Gly Ser Met Leu Pro Phe Lys Arg 
            180                 185                 190         


Gly Ala Phe His Leu Ala Val Gln Ala Gln Val Pro Ile Val Pro Ile 
        195                 200                 205             


Val Met Ser Ser Tyr Gln Asp Phe Tyr Cys Lys Lys Glu Arg Arg Phe 
    210                 215                 220                 


Thr Ser Gly Gln Cys Gln Val Arg Val Leu Pro Pro Val Pro Thr Glu 
225                 230                 235                 240 


Gly Leu Thr Pro Asp Asp Val Pro Ala Leu Ala Asp Arg Val Arg His 
                245                 250                 255     


Ser Met Leu Thr Val Phe Arg Glu Ile Ser Thr Asp Gly Arg Gly Gly 
            260                 265                 270         


Gly Asp Tyr Leu Lys Lys Pro Gly Gly Gly Gly 
        275                 280             


<210>  1663
<211>  1179
<212>  DNA
<213>  Homosapiens

<400>  1663
aggaaacctt gaagcctgcc caacgatcgt gggcaggagg tggtttctgg tttgttgggg     60

cgtgtgtatg tgtatttggg gggactgaag ggtacgtggg gcgaaacaaa accgcaggca    120

ttcagaccaa tagtgattgg ccatggcagc agcggaggag gaggacgggg gccccgaagg    180

gccaaatcgc gagcggggcg gggcgggcgc gaccttcgaa tgtaatatat gtttggagac    240

tgctcgggaa gctgtggtca gtgtgtgtgg ccacctgtac tgttggccat gtcttcatca    300

gtggctggag acacggccag aacggcaaga gtgtccagta tgtaaagctg ggatcagcag    360

agagaaggtt gtcccgcttt atgggcgagg gagccagaag ccccaggatc ccagattaaa    420

aactccaccc cgcccccagg gccagagacc agctccggag agcagagggg gattccagcc    480

atttggtgat accgggggct tccacttctc atttggtgtt ggtgcttttc cctttggctt    540

tttcaccacc gtcttcaatg cccatgagcc tttccgccgg ggtacaggtg tggatctggg    600

acagggtcac ccagcctcca gctggcagga ttccctcttc ctgtttctcg ccatcttctt    660

ctttttttgg ctgctcagta tttgagctat gtctgcttcc tgcccacctc cagccagaga    720

agaatcagta ttgagggtcc ctgctgaccc ttccgtactc ctggaccccc ttgacccctc    780

tatttctgtt ggctaaggcc agccctggac attgtccagg aaggcctggg gaggaggagt    840

gaagtctgtg catagatggg agagccttct gctcagaggc tcactcagta acgttgttta    900

attctctgcc ctggggaagg aggatggatt gagagaatgt ctttctcctc tcctaagtct    960

ttgctttccc tgatttcttg atttgatctt caaaggtggg caaagttccc tctgactctt   1020

cccccactcc ccatcttact gatttaattt aatttttcac tccccagagt ctaatatgga   1080

ttctgactct taagtgcttc cgccccctca ctacctcctt taatacaaat tcaataaaaa   1140

aggtgaaata taaaaaaaaa aaaaaaaaaa aaaaaaaaa                          1179


<210>  1664
<211>  180
<212>  PRT
<213>  Homosapiens

<400>  1664

Met Ala Ala Ala Glu Glu Glu Asp Gly Gly Pro Glu Gly Pro Asn Arg 
1               5                   10                  15      


Glu Arg Gly Gly Ala Gly Ala Thr Phe Glu Cys Asn Ile Cys Leu Glu 
            20                  25                  30          


Thr Ala Arg Glu Ala Val Val Ser Val Cys Gly His Leu Tyr Cys Trp 
        35                  40                  45              


Pro Cys Leu His Gln Trp Leu Glu Thr Arg Pro Glu Arg Gln Glu Cys 
    50                  55                  60                  


Pro Val Cys Lys Ala Gly Ile Ser Arg Glu Lys Val Val Pro Leu Tyr 
65                  70                  75                  80  


Gly Arg Gly Ser Gln Lys Pro Gln Asp Pro Arg Leu Lys Thr Pro Pro 
                85                  90                  95      


Arg Pro Gln Gly Gln Arg Pro Ala Pro Glu Ser Arg Gly Gly Phe Gln 
            100                 105                 110         


Pro Phe Gly Asp Thr Gly Gly Phe His Phe Ser Phe Gly Val Gly Ala 
        115                 120                 125             


Phe Pro Phe Gly Phe Phe Thr Thr Val Phe Asn Ala His Glu Pro Phe 
    130                 135                 140                 


Arg Arg Gly Thr Gly Val Asp Leu Gly Gln Gly His Pro Ala Ser Ser 
145                 150                 155                 160 


Trp Gln Asp Ser Leu Phe Leu Phe Leu Ala Ile Phe Phe Phe Phe Trp 
                165                 170                 175     


Leu Leu Ser Ile 
            180 


<210>  1665
<211>  1414
<212>  DNA
<213>  Homosapiens

<400>  1665
gccaggaccc tggaaggaag caggatggca gccggaacag cagttggagc ctgggtgctg     60

gtcctcagtc tgtggggggc agtagtaggt gctcaaaaca tcacagcccg gattggcgag    120

ccactggtgc tgaagtgtaa gggggccccc aagaaaccac cccagcggct ggaatggaaa    180

ctgaacacag gccggacaga agcttggaag gtcctgtctc cccagggagg aggcccctgg    240

gacagtgtgg ctcgtgtcct tcccaacggc tccctcttcc ttccggctgt cgggatccag    300

gatgagggga ttttccggtg ccaggcaatg aacaggaatg gaaaggagac caagtccaac    360

taccgagtcc gtgtctacca gattcctggg aagccagaaa ttgtagattc tgcctctgaa    420

ctcacggctg gtgttcccaa taaggtgggg acatgtgtgt cagagggaag ctaccctgca    480

gggactctta gctggcactt ggatgggaag cccctggtgc ctaatgagaa gggagtatct    540

gtgaaggaac agaccaggag acaccctgag acagggctct tcacactgca gtcggagcta    600

atggtgaccc cagcccgggg aggagatccc cgtcccacct tctcctgtag cttcagccca    660

ggccttcccc gacaccgggc cttgcgcaca gcccccatcc agccccgtgt ctgggagcct    720

gtgcctctgg aggaggtcca attggtggtg gagccagaag gtggagcagt agctcctggt    780

ggaaccgtaa ccctgacctg tgaagtccct gcccagccct ctcctcaaat ccactggatg    840

aaggatggtg tgcccttgcc ccttcccccc agccctgtgc tgatcctccc tgagataggg    900

cctcaggacc agggaaccta cagctgtgtg gccacccatt ccagccacgg gccccaggaa    960

agccgtgctg tcagcatcag catcatcgaa ccaggcgagg aggggccaac tgcaggctct   1020

gtgggaggat cagggctggg aactctagcc ctggccctgg ggatcctggg aggcctgggg   1080

acagccgccc tgctcattgg ggtcatcttg tggcaaaggc ggcaacgccg aggagaggag   1140

aggaaggccc cagaaaacca ggaggaagag gaggagcgtg cagaactgaa tcagtcggag   1200

gaacctgagg caggcgagag tagtactgga gggccttgag gggcccacag acagatccca   1260

tccatcagct cccttttctt tttcccttga actgttctgg cctcagacca actctctcct   1320

gtataatctc tctcctgtat aaccccacct tgccaagctt tcttctacaa ccagagcccc   1380

ccacaatgat gattaaacac ctgacacatc ttga                               1414


<210>  1666
<211>  404
<212>  PRT
<213>  Homosapiens

<400>  1666

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


<210>  1667
<211>  1259
<212>  DNA
<213>  Homosapiens

<400>  1667
gccaggaccc tggaaggaag caggatggca gccggaacag cagttggagc ctgggtgctg     60

gtcctcagtc tgtggggggc agtagtaggt gctcaaaaca tcacagcccg gattggcgag    120

ccactggtgc tgaagtgtaa gggggccccc aagaaaccac cccagcggct ggaatggaaa    180

ctgggaggag gcccctggga cagtgtggct cgtgtccttc ccaacggctc cctcttcctt    240

ccggctgtcg ggatccagga tgaggggatt ttccggtgcc aggcaatgaa caggaatgga    300

aaggagacca agtccaacta ccgagtccgt gtctaccaga ttcctgggaa gccagaaatt    360

gtagattctg cctctgaact cacggctggt gttcccaata aggtggggac atgtgtgtca    420

gagggaagct accctgcagg gactcttagc tggcacttgg atgggaagcc cctggtgcct    480

aatgagaagg gagtatctgt gaaggaacag accaggagac accctgagac agggctcttc    540

acactgcagt cggagctaat ggtgacccca gcccggggag gagatccccg tcccaccttc    600

tcctgtagct tcagcccagg ccttccccga caccgggcct tgcgcacagc ccccatccag    660

ccccgtgtct gggagcctgt gcctctggag gaggtccaat tggtggtgga gccagaaggt    720

ggagcagtag ctcctggtgg aaccgtaacc ctgacctgtg aagtccctgc ccagccctct    780

cctcaaatcc actggatgaa ggatgtgagt gacctggaga gaggggctgg gagaaccagg    840

cgaggagggg ccaactgcag gctctgtggg aggatcaggg ctgggaactc tagccctggc    900

cctggggatc ctgggaggcc tggggacagc cgccctgctc attggggtca tcttgtggca    960

aaggcggcaa cgccgaggag aggagaggaa ggccccagaa aaccaggagg aagaggagga   1020

gcgtgcagaa ctgaatcagt cggaggaacc tgaggcaggc gagagtagta ctggagggcc   1080

ttgaggggcc cacagacaga tcccatccat cagctccctt ttctttttcc cttgaactgt   1140

tctggcctca gaccaactct ctcctgtata atctctctcc tgtataaccc caccttgcca   1200

agctttcttc tacaaccaga gccccccaca atgatgatta aacacctgac acatcttga    1259


<210>  1668
<211>  342
<212>  PRT
<213>  Homosapiens

<400>  1668

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val 
    50                  55                  60                  


Leu Pro Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu 
65                  70                  75                  80  


Gly Ile Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys 
                85                  90                  95      


Ser Asn Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile 
            100                 105                 110         


Val Asp Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly 
        115                 120                 125             


Thr Cys Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His 
    130                 135                 140                 


Leu Asp Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys 
145                 150                 155                 160 


Glu Gln Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser 
                165                 170                 175     


Glu Leu Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe 
            180                 185                 190         


Ser Cys Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr 
        195                 200                 205             


Ala Pro Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val 
    210                 215                 220                 


Gln Leu Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr 
225                 230                 235                 240 


Val Thr Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His 
                245                 250                 255     


Trp Met Lys Asp Val Ser Asp Leu Glu Arg Gly Ala Gly Arg Thr Arg 
            260                 265                 270         


Arg Gly Gly Ala Asn Cys Arg Leu Cys Gly Arg Ile Arg Ala Gly Asn 
        275                 280                 285             


Ser Ser Pro Gly Pro Gly Asp Pro Gly Arg Pro Gly Asp Ser Arg Pro 
    290                 295                 300                 


Ala His Trp Gly His Leu Val Ala Lys Ala Ala Thr Pro Arg Arg Gly 
305                 310                 315                 320 


Glu Glu Gly Pro Arg Lys Pro Gly Gly Arg Gly Gly Ala Cys Arg Thr 
                325                 330                 335     


Glu Ser Val Gly Gly Thr 
            340         


<210>  1669
<211>  3210
<212>  DNA
<213>  Homosapiens

<400>  1669
ctctctcaca cacacccccg cttgggcctc ctctctctct ccggctccat tttctccgcc     60

gccgggggcc ggggtctcct gtggggggcc cagccggtat cccaggtctc ccttcagtgc    120

cggggtgaac ccccggggga gccgggagcc gggggcagac gggcgggggt tggggcggag    180

ggagcagcgg ccccagcgag tttgggggga gaagtaacca ggcgggggga ggggcggagc    240

agggaggggg cctcagggcc cccccccagc tatggacgaa cggctactgg ggccgccccc    300

tccaggcggg ggccgggggg gcctgggatt ggtgagtggg gagcctgggg gccctggcga    360

gcctcccggt ggcggagacc ccggtggggg tagcgggggg gtcccgggag gccgagggaa    420

gcaagacatc ggggacattc tgcagcagat aatgaccatc accgaccaga gcctggacga    480

ggcccaggcc aagaaacacg ccctaaactg ccaccgaatg aagcctgctc tctttagcgt    540

cctgtgtgaa atcaaggaga aaactggcct cagcattcgg agctcccagg aggaggagcc    600

ggtggaccca cagctgatgc gcttggacaa catgcttctg gcagagggtg tggctgggcc    660

cgagaaaggg ggcggctcag cagcagcagc tgcagccgct gcagcctctg gtggtggtgt    720

gtcccctgac aactccatcg aacactcgga ctatcgcagc aaacttgccc agatccgtca    780

catataccac tcggagctgg agaagtatga gcaggcatgt aatgagttca cgacccatgt    840

catgaacctg ctgagggagc agagccgcac caggcccgtg gcccccaaag agatggaacg    900

catggtgagc atcatccatc gaaagttcag cgccatccag atgcagctga agcagagcac    960

ctgcgaggct gtgatgatcc tgcgctcccg tttcctggat gccagacgaa agcgccgtaa   1020

cttcagcaaa caggccactg aggtcctaaa tgagtatttc tactcccacc tgagtaaccc   1080

atatcctagt gaggaggcca aggaggagct tgccaagaag tgtggcatca ccgtgtctca   1140

ggtctccaac tggtttggca acaagaggat tcgctataag aaaaacatcg gaaagttcca   1200

agaggaggca aacatctatg ctgtcaagac cgccgtgtca gtcacccagg ggggccacag   1260

ccgcaccagc tccccgacac ccccttcctc tgcaggctct ggcggctctt tcaatctctc   1320

aggatctgga gacatgtttc tggggatgcc tgggctcaac ggagattcct attctgcttc   1380

ccaggtggaa tcactccgac actcgatggg gccagggggc tatggggata acctcggggg   1440

aggccagatg tacagcccac gggaaatgag ggcaaatggc agctggcaag aggctgtgac   1500

cccctcttca gtgacatccc caacggaggg accagggagt gttcactctg atacctccaa   1560

ctgatcttgc ccctcagggt cacaggggtg ggggctctca caaggcgact tgaagaggac   1620

gcaggcttcc agaggacaaa ccccaataca ggagaagcac aagacagaga agggccaatg   1680

gggtcatccc ctccctaacg agactctctg tgctgggggt gctaattaca tggcaggaag   1740

aatggggcct ctaaggggag tgtggggtct gtctctccct tttttccatc tttttcctct   1800

ctcgctttct ttcttacaca gaaacataca cataccgaga aacctatttc tcagacccct   1860

ttttctcctc tgtctttctc tctccctctc ccacacctca cacacacata ctcccacttg   1920

caactattct gtttctctcc tgggctcccc cactttccct tccccacccc acttgtatgc   1980

tctggaatct gtggagacgc cagccctgcc caatcagaga tgccaaaaat ggggacatga   2040

cttctggaca gaggacatgg gccacgcccc catgcatccc cacccccgcc cctccggacg   2100

gcttacttac ctcatacgca gctcatctta aaccaataga atcgctcggt ggacgagagt   2160

gtctgactca gatatctacc tcggagggag tttctgctac tttagggaat tattgactgg   2220

gctttggggt tgaacttttt tttttttaaa gaaagaaaaa gaaaccctgg gatccatctg   2280

ttttttttgt tgttgttgtt gtttttgttg ttgttggtgg tggtggtggt ggtggttctt   2340

aatttttaat ttagtttggg gaagtagctt gttttttttt ttataaatat gttgatttct   2400

tgtctttttt ttttatttct tactttccca tattaggggt gatagccaaa ggggttctgg   2460

taagagaaag ggggacaaac agaactggta aagaggcccc cctggctcca ggcctgtcca   2520

tcaggaagta aattttacag ggcaccaagc tttgccccct aaaatccctt aggtgttctt   2580

tgttcatgca ggcaggtttc tgccgcattt gatgtggagg cagtgaaggg cttgccctgc   2640

tggcctctca tcccccttct tcccacaacc cttgggcagg gctggactca gtaattttga   2700

ggaaattgaa gatgccatct tcccctgtga gtgacatgtc tttaattttt taaaaaacta   2760

ctatttgaaa attggagggg gaagaatggg aagggagtta ttgccaaata tgttaaatat   2820

gggttggggt gcttgtatat gtatcttcct caatttcccc ataaatgagg tatctttttg   2880

tcacaccaaa atcaaggggt agggagaggg aggaggttgc aaaaagccag atgtggggga   2940

aaagtaacat caacactgtc ccatcctcag ccctgaacta gctaccatct gatcccctca   3000

gacattctca ggattttaca agactgtcag agtggggaac ccctcccatt aaagatccgg   3060

gcaggactgg ggacaggttg gaagtgtgat gggtgggggg gtgggaggca tgggccgggg   3120

gcagttctct cctcacttgt aaacttgtgt agtttcacag aaaaaaaaca aaatgcagtt   3180

ttaaataaag aaatttcttt ttaaaaaaaa                                    3210


<210>  1670
<211>  430
<212>  PRT
<213>  Homosapiens

<400>  1670

Met Asp Glu Arg Leu Leu Gly Pro Pro Pro Pro Gly Gly Gly Arg Gly 
1               5                   10                  15      


Gly Leu Gly Leu Val Ser Gly Glu Pro Gly Gly Pro Gly Glu Pro Pro 
            20                  25                  30          


Gly Gly Gly Asp Pro Gly Gly Gly Ser Gly Gly Val Pro Gly Gly Arg 
        35                  40                  45              


Gly Lys Gln Asp Ile Gly Asp Ile Leu Gln Gln Ile Met Thr Ile Thr 
    50                  55                  60                  


Asp Gln Ser Leu Asp Glu Ala Gln Ala Lys Lys His Ala Leu Asn Cys 
65                  70                  75                  80  


His Arg Met Lys Pro Ala Leu Phe Ser Val Leu Cys Glu Ile Lys Glu 
                85                  90                  95      


Lys Thr Gly Leu Ser Ile Arg Ser Ser Gln Glu Glu Glu Pro Val Asp 
            100                 105                 110         


Pro Gln Leu Met Arg Leu Asp Asn Met Leu Leu Ala Glu Gly Val Ala 
        115                 120                 125             


Gly Pro Glu Lys Gly Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ala Ser Gly Gly Gly Val Ser Pro Asp Asn Ser Ile Glu His Ser Asp 
145                 150                 155                 160 


Tyr Arg Ser Lys Leu Ala Gln Ile Arg His Ile Tyr His Ser Glu Leu 
                165                 170                 175     


Glu Lys Tyr Glu Gln Ala Cys Asn Glu Phe Thr Thr His Val Met Asn 
            180                 185                 190         


Leu Leu Arg Glu Gln Ser Arg Thr Arg Pro Val Ala Pro Lys Glu Met 
        195                 200                 205             


Glu Arg Met Val Ser Ile Ile His Arg Lys Phe Ser Ala Ile Gln Met 
    210                 215                 220                 


Gln Leu Lys Gln Ser Thr Cys Glu Ala Val Met Ile Leu Arg Ser Arg 
225                 230                 235                 240 


Phe Leu Asp Ala Arg Arg Lys Arg Arg Asn Phe Ser Lys Gln Ala Thr 
                245                 250                 255     


Glu Val Leu Asn Glu Tyr Phe Tyr Ser His Leu Ser Asn Pro Tyr Pro 
            260                 265                 270         


Ser Glu Glu Ala Lys Glu Glu Leu Ala Lys Lys Cys Gly Ile Thr Val 
        275                 280                 285             


Ser Gln Val Ser Asn Trp Phe Gly Asn Lys Arg Ile Arg Tyr Lys Lys 
    290                 295                 300                 


Asn Ile Gly Lys Phe Gln Glu Glu Ala Asn Ile Tyr Ala Val Lys Thr 
305                 310                 315                 320 


Ala Val Ser Val Thr Gln Gly Gly His Ser Arg Thr Ser Ser Pro Thr 
                325                 330                 335     


Pro Pro Ser Ser Ala Gly Ser Gly Gly Ser Phe Asn Leu Ser Gly Ser 
            340                 345                 350         


Gly Asp Met Phe Leu Gly Met Pro Gly Leu Asn Gly Asp Ser Tyr Ser 
        355                 360                 365             


Ala Ser Gln Val Glu Ser Leu Arg His Ser Met Gly Pro Gly Gly Tyr 
    370                 375                 380                 


Gly Asp Asn Leu Gly Gly Gly Gln Met Tyr Ser Pro Arg Glu Met Arg 
385                 390                 395                 400 


Ala Asn Gly Ser Trp Gln Glu Ala Val Thr Pro Ser Ser Val Thr Ser 
                405                 410                 415     


Pro Thr Glu Gly Pro Gly Ser Val His Ser Asp Thr Ser Asn 
            420                 425                 430 


<210>  1671
<211>  1472
<212>  DNA
<213>  Homosapiens

<400>  1671
ccggagcggg gatcacctta acttgactgt ggtcccccag ccctccaaga aatgcccata     60

aaccaaggag gagagggtaa aaaatagaag aatacatgga attggggaga agaatgggaa    120

aaaagatggg agtgactgca taatgtcagc attttgtgct tttggctcag catttggatt    180

ggatggagga ttttcatcct gaaaccagcc ctccgtcgcc accgaccatg gaataattgt    240

cttccacgaa actcttccct ggtgccaaaa agggttttat gtatatattt gagagctcca    300

catccctgga tctgaatcct ccacttccca ctggaaccat gcccctccca gtcccgtttc    360

tcccctctag gggatggagg ctgagagacc ccaggaagaa gaggatggtg agcagggccc    420

ccctcaggat gaggaaggct ggccccctcc aaactccacc actcggcctt ggcgatctgc    480

tcctccatcc cctcctcctc cagggacccg ccacacagcc ctgggacccc gctcggcctc    540

cctgctctcc ctgcagactg aactccttct ggacctggtg gctgaagccc agtcccgccg    600

cctggaggag cagagggcca ccttctacac cccccaaaac ccctcaagcc tagcccctgc    660

cccactccgt cctctcgagg acagagaaca gctttacagc actatcctca gtcaccagtg    720

ccagcggatg gaagcccagc ggtcagagcc tcccctccct ccaggggggc aagagctcct    780

ggagttgctg ctgagagttc agggtggggg tcgaatggag gagcaaaggt cccggccccc    840

cacacacacc tgctgagact tgagccccaa ccagcccttc cttgccactg gtctcaaagc    900

tgggcagccc attgcatgcc ctcaactctt gcttggcagg ggtaccagag actgaaagac    960

acggcacaaa tctcaatatt catctcccac atcaccttcc ctgggaactg gacagggtga   1020

aagtcctcaa actctgggaa caggcgagat ggaacaggga tttaactccc cgcccacagg   1080

tccatgggag cttgaggcag taagggggat cccaggcacc catctcaagg agtggctggg   1140

agtcttttcc ctaacttgtg gggacaccac cagttgtcaa gctactaggc agtagggtct   1200

gagggctcag gcctccacct gagaggttat aacctgagag acagctctac ccttcctccc   1260

agtaagaagg gaaggtgggt gggcacctga gagattaaga ctattctccc agtcccacta   1320

ccagcacccc cgatccctga gactgagggg tttacgggct gtgaatggac cttcagccct   1380

gcccaccctc cctccccact gctgctgagt ctgtctgatg ttttggttgt gtgaataaat   1440

ataattcccc tctggaaaaa aaaaaaaaaa aa                                 1472


<210>  1672
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  1672

Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210>  1673
<211>  6762
<212>  DNA
<213>  Homosapiens

<400>  1673
agacgtgagg cttgcagcag gccgaggagg aagaagaggg gcagtgggag cagaggaggt     60

ggctcctgcc ccagtgagag ctctgagggt ccctgcctga agagggacag ggaccggggc    120

ttggagaagg ggctgtggaa tgcagccccc ttcactgctg ctgctgctgc tgctgctgct    180

gctgctatgt gtctcagtgg tcagacccag agggctgctg tgtgggagtt tcccagaacc    240

ctgtgccaat ggaggcacct gcctgagcct gtctctggga caagggacct gccagtgtgc    300

ccctggcttc ctgggtgaga cgtgccagtt tcctgacccc tgccagaacg cccagctctg    360

ccaaaatgga ggcagctgcc aagccctgct tcccgctccc ctagggctcc ccagctctcc    420

ctctccattg acacccagct tcttgtgcac ttgcctccct ggcttcactg gtgagagatg    480

ccaggccaag cttgaagacc cttgtcctcc ctccttctgt tccaaaaggg gccgctgcca    540

catccaggcc tcgggccgcc cacagtgctc ctgcatgcct ggatggacag gtgagcagtg    600

ccagcttcgg gacttctgtt cagccaaccc atgtgttaat ggaggggtgt gtctggccac    660

atacccccag atccagtgcc actgcccacc gggcttcgag ggccatgcct gtgaacgtga    720

tgtcaacgag tgcttccagg acccaggacc ctgccccaaa ggcacctcct gccataacac    780

cctgggctcc ttccagtgcc tctgccctgt ggggcaggag ggtccacgtt gtgagctgcg    840

ggcaggaccc tgccctccta ggggctgttc gaatgggggc acctgccagc tgatgccaga    900

gaaagactcc acctttcacc tctgcctctg tcccccaggt ttcataggcc cagactgtga    960

ggtgaatcca gacaactgtg tcagccacca gtgtcagaat gggggcactt gccaggatgg   1020

gctggacacc tacacctgcc tctgcccaga aacctggaca ggctgggact gctccgaaga   1080

tgtggatgag tgtgagaccc agggtccccc tcactgcaga aacgggggca cctgccagaa   1140

ctctgctggt agctttcact gcgtgtgtgt gagtggctgg ggcggcacaa gctgtgagga   1200

gaacctggat gactgtattg ctgccacctg tgccccggga tccacctgca ttgaccgggt   1260

gggctctttc tcctgcctct gcccacctgg acgcacagga ctcctgtgcc acttggaaga   1320

catgtgtctg agccagccgt gccatgggga tgcccaatgc agcaccaacc ccctcacagg   1380

ctccacactc tgcctgtgtc agcctggcta ttcggggccc acctgccacc aggacctgga   1440

cgagtgtctg atggcccagc aaggcccaag tccctgtgaa catggcggtt cctgcctcaa   1500

cactcctggc tccttcaact gcctctgtcc acctggctac acaggctccc gttgtgaggc   1560

tgatcacaat gagtgcctct cccagccctg ccacccagga agcacctgtc tggacctact   1620

tgccaccttc cactgcctct gcccgccagg cttagaaggg cagctctgtg aggtggagac   1680

caacgagtgt gcctcagctc cctgcctgaa ccacgcggat tgccatgacc tgctcaacgg   1740

cttccagtgc atctgcctgc ctggattctc cggcacccga tgtgaggagg atatcgatga   1800

gtgcagaagc tctccctgtg ccaatggtgg gcagtgccag gaccagcctg gagccttcca   1860

ctgcaagtgt ctcccaggct ttgaagggcc acgctgtcaa acagaggtgg atgagtgcct   1920

gagtgaccca tgtcccgttg gagccagctg ccttgatctt ccaggagcct tcttttgcct   1980

ctgcccctct ggtttcacag gccagctctg tgaggttccc ctgtgtgctc ccaacctgtg   2040

ccagcccaag cagatatgta aggaccagaa agacaaggcc aactgcctct gtcctgatgg   2100

aagccctggc tgtgccccac ctgaggacaa ctgcacctgc caccacgggc actgccagag   2160

atcctcatgt gtgtgtgacg tgggttggac ggggccagag tgtgaggcag agctaggggg   2220

ctgcatctct gcaccctgtg cccatggggg gacctgctac ccccagccct ctggctacaa   2280

ctgcacctgc cctacaggct acacaggacc cacctgtagt gaggagatga cagcttgtca   2340

ctcagggcca tgtctcaatg gcggctcctg caaccctagc cctggaggct actactgcac   2400

ctgccctcca agccacacag ggccccagtg ccaaaccagc actgactact gtgtgtctgc   2460

cccgtgcttc aatgggggta cctgtgtgaa caggcctggc accttctcct gcctctgtgc   2520

catgggcttc cagggcccgc gctgtgaggg aaagctccgc cccagctgtg cagacagccc   2580

ctgtaggaat agggcaacct gccaggacag ccctcagggt ccccgctgcc tctgccccac   2640

tggctacacc ggaggcagct gccagactct gatggactta tgtgcccaga agccctgccc   2700

acgcaattcc cactgcctcc agactgggcc ctccttccac tgcttgtgcc tccagggatg   2760

gaccgggcct ctctgcaacc ttccactgtc ctcctgccag aaggctgcac tgagccaagg   2820

catagacgtc tcttcccttt gccacaatgg aggcctctgt gtcgacagcg gcccctccta   2880

tttctgccac tgcccccctg gattccaagg cagcctgtgc caggatcacg tgaacccatg   2940

tgagtccagg ccttgccaga acggggccac ctgcatggcc cagcccagtg ggtatctctg   3000

ccagtgtgcc ccaggctacg atggacagaa ctgctcaaag gaactcgatg cttgtcagtc   3060

ccaaccctgt cacaaccatg gaacctgtac tcccaaacct ggaggattcc actgtgcctg   3120

ccctccaggc tttgtggggc tacgctgtga gggagacgtg gacgagtgtc tggaccagcc   3180

ctgccacccc acaggcactg cagcctgcca ctctctggcc aatgccttct actgccagtg   3240

tctgcctgga cacacaggcc agtggtgtga ggtggagata gacccctgcc acagccaacc   3300

ctgctttcat ggagggacct gtgaggccac agcaggatca cccctgggtt tcatctgcca   3360

ctgccccaag ggttttgaag gccccacctg cagccacagg gccccttcct gcggcttcca   3420

tcactgccac cacggaggcc tgtgtctgcc ctcccctaag ccaggcttcc caccacgctg   3480

tgcctgcctc agtggctatg ggggtcctga ctgcctgacc ccaccagctc ctaaaggctg   3540

tggccctccc tccccatgcc tatacaatgg cagctgctca gagaccacgg gcttgggggg   3600

cccaggcttt cgatgctcct gccctcacag ctctccaggg ccccggtgtc agaaacccgg   3660

agccaagggg tgtgagggca gaagtggaga tggggcctgc gatgctggct gcagtggccc   3720

gggaggaaac tgggatggag gggactgctc tctgggagtc ccagacccct ggaagggctg   3780

cccctcccac tctcggtgct ggcttctctt ccgggacggg cagtgccacc cacagtgtga   3840

ctctgaagag tgtctgtttg atggctacga ctgtgagacc cctccagcct gcactccagc   3900

ctatgaccag tactgccatg atcacttcca caacgggcac tgtgagaaag gctgcaacac   3960

tgcagagtgt ggctgggatg gaggtgactg caggcctgaa gatggggacc cagagtgggg   4020

gccctccctg gccctgctgg tggtactgag ccccccagcc ctagaccagc agctgtttgc   4080

cctggcccgg gtgctgtccc tgactctgag ggtaggactc tgggtaagga aggatcgtga   4140

tggcagggac atggtgtacc cctatcctgg ggcccgggct gaagaaaagc taggaggaac   4200

tcgggacccc acctatcagg agagagcagc ccctcaaacg cagcccctgg gcaaggagac   4260

cgactccctc agtgctgggt ttgtggtggt catgggtgtg gatttgtccc gctgtggccc   4320

tgaccacccg gcatcccgct gtccctggga ccctgggctt ctactccgct tccttgctgc   4380

gatggctgca gtgggagccc tggagcccct gctgcctgga ccactgctgg ctgtccaccc   4440

tcatgcaggg accgcacccc ctgccaacca gcttccctgg cctgtgctgt gctccccagt   4500

ggccggggtg attctcctgg ccctaggggc tcttctcgtc ctccagctca tccggcgtcg   4560

acgccgagag catggagctc tctggctgcc ccctggtttc actcgacggc ctcggactca   4620

gtcagctccc caccgacgcc ggcccccact aggcgaggac agcattggtc tcaaggcact   4680

gaagccaaag gcagaagttg atgaggatgg agttgtgatg tgctcaggcc ctgaggaggg   4740

agaggaggtg ggccaggctg aagaaacagg cccaccctcc acgtgccagc tctggtctct   4800

gagtggtggc tgtggggcgc tccctcaggc agccatgcta actcctcccc aggaatctga   4860

gatggaagcc cctgacctgg acacccgtgg acctgatggg gtgacacccc tgatgtcagc   4920

agtttgctgt ggggaagtac agtccgggac cttccaaggg gcatggttgg gatgtcctga   4980

gccctgggaa cctctgctgg atggaggggc ctgtccccag gctcacaccg tgggcactgg   5040

ggagaccccc ctgcacctgg ctgcccgatt ctcccggcca accgctgccc gccgcctcct   5100

tgaggctgga gccaacccca accagccaga ccgggcaggg cgcacacccc ttcatgctgc   5160

tgtggctgct gatgctcggg aggtctgcca gcttctgctc cgtagcagac aaactgcagt   5220

ggacgctcgc acagaggacg ggaccacacc cttgatgctg gctgccaggc tggcggtgga   5280

agacctggtt gaagaactga ttgcagccca agcagacgtg ggggccagag ataaatgggg   5340

gaaaactgcg ctgcactggg ctgctgccgt gaacaacgcc cgagccgccc gctcgcttct   5400

ccaggccgga gccgataaag atgcccagga caacagggag cagacgccgc tattcctggc   5460

ggcgcgggaa ggagcggtgg aagtagccca gctactgctg gggctggggg cagcccgaga   5520

gctgcgggac caggctgggc tagcgccggc ggacgtcgct caccaacgta accactggga   5580

tctgctgacg ctgctggaag gggctgggcc accagaggcc cgtcacaaag ccacgccggg   5640

ccgcgaggct gggcccttcc cgcgcgcacg gacggtgtca gtaagcgtgc ccccgcatgg   5700

gggcggggct ctgccgcgct gccggacgct gtcagccgga gcaggccctc gtgggggcgg   5760

agcttgtctg caggctcgga cttggtccgt agacttggct gcgcgggggg gcggggccta   5820

ttctcattgc cggagcctct cgggagtagg agcaggagga ggcccgaccc ctcgcggccg   5880

taggttttct gcaggcatgc gcgggcctcg gcccaaccct gcgataatgc gaggaagata   5940

cggagtggct gccgggcgcg gaggcagggt ctcaacggat gactggccct gtgattgggt   6000

ggccctggga gcttgcggtt ctgcctccaa cattccgatc ccgcctcctt gccttactcc   6060

gtccccggag cggggatcac ctcaacttga ctgtggtccc ccagccctcc aagaaatgcc   6120

cataaaccaa ggaggagagg gtaaaaaata gaagaataca tggtagggag gaattccaaa   6180

aatgattacc cattaaaagg caggctggaa ggccttcctg gttttaagat ggatccccca   6240

aaatgaaggg ttgtgagttt agtttctctc ctaaaatgaa tgtatgccca ccagagcaga   6300

catcttccac gtggagaagc tgcagctctg gaaagagggt ttaagatgct aggatgaggc   6360

aggcccagtc ctcctccaga aaataagaca ggccacagga gggcagagtg gagtggaaat   6420

acccctaagt tggaaccaag aattgcaggc atatgggatg taagatgttc tttcctatat   6480

atggtttcca aagggtgccc ctatgatcca ttgtccccac tgcccacaaa tggctgacaa   6540

atatttattg ggcacctact atgtgccagg cactgtgtag gtgctgaaaa gtggccaagg   6600

gccacccccg ctgatgactc cttgcattcc ctcccctcac aacaaagaac tccactgtgg   6660

ggatgaagcg cttcttctag ccactgctat cgctatttaa gaaccctaaa tctgtcaccc   6720

ataataaagc tgatttgaag tgttaaaaaa aaaaaaaaaa aa                      6762


<210>  1674
<211>  2003
<212>  PRT
<213>  Homosapiens

<400>  1674

Met Gln Pro Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Cys Val Ser Val Val Arg Pro Arg Gly Leu Leu Cys Gly Ser Phe Pro 
            20                  25                  30          


Glu Pro Cys Ala Asn Gly Gly Thr Cys Leu Ser Leu Ser Leu Gly Gln 
        35                  40                  45              


Gly Thr Cys Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe 
    50                  55                  60                  


Pro Asp Pro Cys Gln Asn Ala Gln Leu Cys Gln Asn Gly Gly Ser Cys 
65                  70                  75                  80  


Gln Ala Leu Leu Pro Ala Pro Leu Gly Leu Pro Ser Ser Pro Ser Pro 
                85                  90                  95      


Leu Thr Pro Ser Phe Leu Cys Thr Cys Leu Pro Gly Phe Thr Gly Glu 
            100                 105                 110         


Arg Cys Gln Ala Lys Leu Glu Asp Pro Cys Pro Pro Ser Phe Cys Ser 
        115                 120                 125             


Lys Arg Gly Arg Cys His Ile Gln Ala Ser Gly Arg Pro Gln Cys Ser 
    130                 135                 140                 


Cys Met Pro Gly Trp Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys 
145                 150                 155                 160 


Ser Ala Asn Pro Cys Val Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro 
                165                 170                 175     


Gln Ile Gln Cys His Cys Pro Pro Gly Phe Glu Gly His Ala Cys Glu 
            180                 185                 190         


Arg Asp Val Asn Glu Cys Phe Gln Asp Pro Gly Pro Cys Pro Lys Gly 
        195                 200                 205             


Thr Ser Cys His Asn Thr Leu Gly Ser Phe Gln Cys Leu Cys Pro Val 
    210                 215                 220                 


Gly Gln Glu Gly Pro Arg Cys Glu Leu Arg Ala Gly Pro Cys Pro Pro 
225                 230                 235                 240 


Arg Gly Cys Ser Asn Gly Gly Thr Cys Gln Leu Met Pro Glu Lys Asp 
                245                 250                 255     


Ser Thr Phe His Leu Cys Leu Cys Pro Pro Gly Phe Ile Gly Pro Asp 
            260                 265                 270         


Cys Glu Val Asn Pro Asp Asn Cys Val Ser His Gln Cys Gln Asn Gly 
        275                 280                 285             


Gly Thr Cys Gln Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Glu 
    290                 295                 300                 


Thr Trp Thr Gly Trp Asp Cys Ser Glu Asp Val Asp Glu Cys Glu Thr 
305                 310                 315                 320 


Gln Gly Pro Pro His Cys Arg Asn Gly Gly Thr Cys Gln Asn Ser Ala 
                325                 330                 335     


Gly Ser Phe His Cys Val Cys Val Ser Gly Trp Gly Gly Thr Ser Cys 
            340                 345                 350         


Glu Glu Asn Leu Asp Asp Cys Ile Ala Ala Thr Cys Ala Pro Gly Ser 
        355                 360                 365             


Thr Cys Ile Asp Arg Val Gly Ser Phe Ser Cys Leu Cys Pro Pro Gly 
    370                 375                 380                 


Arg Thr Gly Leu Leu Cys His Leu Glu Asp Met Cys Leu Ser Gln Pro 
385                 390                 395                 400 


Cys His Gly Asp Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr 
                405                 410                 415     


Leu Cys Leu Cys Gln Pro Gly Tyr Ser Gly Pro Thr Cys His Gln Asp 
            420                 425                 430         


Leu Asp Glu Cys Leu Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His 
        435                 440                 445             


Gly Gly Ser Cys Leu Asn Thr Pro Gly Ser Phe Asn Cys Leu Cys Pro 
    450                 455                 460                 


Pro Gly Tyr Thr Gly Ser Arg Cys Glu Ala Asp His Asn Glu Cys Leu 
465                 470                 475                 480 


Ser Gln Pro Cys His Pro Gly Ser Thr Cys Leu Asp Leu Leu Ala Thr 
                485                 490                 495     


Phe His Cys Leu Cys Pro Pro Gly Leu Glu Gly Gln Leu Cys Glu Val 
            500                 505                 510         


Glu Thr Asn Glu Cys Ala Ser Ala Pro Cys Leu Asn His Ala Asp Cys 
        515                 520                 525             


His Asp Leu Leu Asn Gly Phe Gln Cys Ile Cys Leu Pro Gly Phe Ser 
    530                 535                 540                 


Gly Thr Arg Cys Glu Glu Asp Ile Asp Glu Cys Arg Ser Ser Pro Cys 
545                 550                 555                 560 


Ala Asn Gly Gly Gln Cys Gln Asp Gln Pro Gly Ala Phe His Cys Lys 
                565                 570                 575     


Cys Leu Pro Gly Phe Glu Gly Pro Arg Cys Gln Thr Glu Val Asp Glu 
            580                 585                 590         


Cys Leu Ser Asp Pro Cys Pro Val Gly Ala Ser Cys Leu Asp Leu Pro 
        595                 600                 605             


Gly Ala Phe Phe Cys Leu Cys Pro Ser Gly Phe Thr Gly Gln Leu Cys 
    610                 615                 620                 


Glu Val Pro Leu Cys Ala Pro Asn Leu Cys Gln Pro Lys Gln Ile Cys 
625                 630                 635                 640 


Lys Asp Gln Lys Asp Lys Ala Asn Cys Leu Cys Pro Asp Gly Ser Pro 
                645                 650                 655     


Gly Cys Ala Pro Pro Glu Asp Asn Cys Thr Cys His His Gly His Cys 
            660                 665                 670         


Gln Arg Ser Ser Cys Val Cys Asp Val Gly Trp Thr Gly Pro Glu Cys 
        675                 680                 685             


Glu Ala Glu Leu Gly Gly Cys Ile Ser Ala Pro Cys Ala His Gly Gly 
    690                 695                 700                 


Thr Cys Tyr Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys Pro Thr Gly 
705                 710                 715                 720 


Tyr Thr Gly Pro Thr Cys Ser Glu Glu Met Thr Ala Cys His Ser Gly 
                725                 730                 735     


Pro Cys Leu Asn Gly Gly Ser Cys Asn Pro Ser Pro Gly Gly Tyr Tyr 
            740                 745                 750         


Cys Thr Cys Pro Pro Ser His Thr Gly Pro Gln Cys Gln Thr Ser Thr 
        755                 760                 765             


Asp Tyr Cys Val Ser Ala Pro Cys Phe Asn Gly Gly Thr Cys Val Asn 
    770                 775                 780                 


Arg Pro Gly Thr Phe Ser Cys Leu Cys Ala Met Gly Phe Gln Gly Pro 
785                 790                 795                 800 


Arg Cys Glu Gly Lys Leu Arg Pro Ser Cys Ala Asp Ser Pro Cys Arg 
                805                 810                 815     


Asn Arg Ala Thr Cys Gln Asp Ser Pro Gln Gly Pro Arg Cys Leu Cys 
            820                 825                 830         


Pro Thr Gly Tyr Thr Gly Gly Ser Cys Gln Thr Leu Met Asp Leu Cys 
        835                 840                 845             


Ala Gln Lys Pro Cys Pro Arg Asn Ser His Cys Leu Gln Thr Gly Pro 
    850                 855                 860                 


Ser Phe His Cys Leu Cys Leu Gln Gly Trp Thr Gly Pro Leu Cys Asn 
865                 870                 875                 880 


Leu Pro Leu Ser Ser Cys Gln Lys Ala Ala Leu Ser Gln Gly Ile Asp 
                885                 890                 895     


Val Ser Ser Leu Cys His Asn Gly Gly Leu Cys Val Asp Ser Gly Pro 
            900                 905                 910         


Ser Tyr Phe Cys His Cys Pro Pro Gly Phe Gln Gly Ser Leu Cys Gln 
        915                 920                 925             


Asp His Val Asn Pro Cys Glu Ser Arg Pro Cys Gln Asn Gly Ala Thr 
    930                 935                 940                 


Cys Met Ala Gln Pro Ser Gly Tyr Leu Cys Gln Cys Ala Pro Gly Tyr 
945                 950                 955                 960 


Asp Gly Gln Asn Cys Ser Lys Glu Leu Asp Ala Cys Gln Ser Gln Pro 
                965                 970                 975     


Cys His Asn His Gly Thr Cys Thr Pro Lys Pro Gly Gly Phe His Cys 
            980                 985                 990         


Ala Cys Pro Pro Gly Phe Val Gly  Leu Arg Cys Glu Gly  Asp Val Asp 
        995                 1000                 1005             


Glu Cys  Leu Asp Gln Pro Cys  His Pro Thr Gly Thr  Ala Ala Cys 
    1010                 1015                 1020             


His Ser  Leu Ala Asn Ala Phe  Tyr Cys Gln Cys Leu  Pro Gly His 
    1025                 1030                 1035             


Thr Gly  Gln Trp Cys Glu Val  Glu Ile Asp Pro Cys  His Ser Gln 
    1040                 1045                 1050             


Pro Cys  Phe His Gly Gly Thr  Cys Glu Ala Thr Ala  Gly Ser Pro 
    1055                 1060                 1065             


Leu Gly  Phe Ile Cys His Cys  Pro Lys Gly Phe Glu  Gly Pro Thr 
    1070                 1075                 1080             


Cys Ser  His Arg Ala Pro Ser  Cys Gly Phe His His  Cys His His 
    1085                 1090                 1095             


Gly Gly  Leu Cys Leu Pro Ser  Pro Lys Pro Gly Phe  Pro Pro Arg 
    1100                 1105                 1110             


Cys Ala  Cys Leu Ser Gly Tyr  Gly Gly Pro Asp Cys  Leu Thr Pro 
    1115                 1120                 1125             


Pro Ala  Pro Lys Gly Cys Gly  Pro Pro Ser Pro Cys  Leu Tyr Asn 
    1130                 1135                 1140             


Gly Ser  Cys Ser Glu Thr Thr  Gly Leu Gly Gly Pro  Gly Phe Arg 
    1145                 1150                 1155             


Cys Ser  Cys Pro His Ser Ser  Pro Gly Pro Arg Cys  Gln Lys Pro 
    1160                 1165                 1170             


Gly Ala  Lys Gly Cys Glu Gly  Arg Ser Gly Asp Gly  Ala Cys Asp 
    1175                 1180                 1185             


Ala Gly  Cys Ser Gly Pro Gly  Gly Asn Trp Asp Gly  Gly Asp Cys 
    1190                 1195                 1200             


Ser Leu  Gly Val Pro Asp Pro  Trp Lys Gly Cys Pro  Ser His Ser 
    1205                 1210                 1215             


Arg Cys  Trp Leu Leu Phe Arg  Asp Gly Gln Cys His  Pro Gln Cys 
    1220                 1225                 1230             


Asp Ser  Glu Glu Cys Leu Phe  Asp Gly Tyr Asp Cys  Glu Thr Pro 
    1235                 1240                 1245             


Pro Ala  Cys Thr Pro Ala Tyr  Asp Gln Tyr Cys His  Asp His Phe 
    1250                 1255                 1260             


His Asn  Gly His Cys Glu Lys  Gly Cys Asn Thr Ala  Glu Cys Gly 
    1265                 1270                 1275             


Trp Asp  Gly Gly Asp Cys Arg  Pro Glu Asp Gly Asp  Pro Glu Trp 
    1280                 1285                 1290             


Gly Pro  Ser Leu Ala Leu Leu  Val Val Leu Ser Pro  Pro Ala Leu 
    1295                 1300                 1305             


Asp Gln  Gln Leu Phe Ala Leu  Ala Arg Val Leu Ser  Leu Thr Leu 
    1310                 1315                 1320             


Arg Val  Gly Leu Trp Val Arg  Lys Asp Arg Asp Gly  Arg Asp Met 
    1325                 1330                 1335             


Val Tyr  Pro Tyr Pro Gly Ala  Arg Ala Glu Glu Lys  Leu Gly Gly 
    1340                 1345                 1350             


Thr Arg  Asp Pro Thr Tyr Gln  Glu Arg Ala Ala Pro  Gln Thr Gln 
    1355                 1360                 1365             


Pro Leu  Gly Lys Glu Thr Asp  Ser Leu Ser Ala Gly  Phe Val Val 
    1370                 1375                 1380             


Val Met  Gly Val Asp Leu Ser  Arg Cys Gly Pro Asp  His Pro Ala 
    1385                 1390                 1395             


Ser Arg  Cys Pro Trp Asp Pro  Gly Leu Leu Leu Arg  Phe Leu Ala 
    1400                 1405                 1410             


Ala Met  Ala Ala Val Gly Ala  Leu Glu Pro Leu Leu  Pro Gly Pro 
    1415                 1420                 1425             


Leu Leu  Ala Val His Pro His  Ala Gly Thr Ala Pro  Pro Ala Asn 
    1430                 1435                 1440             


Gln Leu  Pro Trp Pro Val Leu  Cys Ser Pro Val Ala  Gly Val Ile 
    1445                 1450                 1455             


Leu Leu  Ala Leu Gly Ala Leu  Leu Val Leu Gln Leu  Ile Arg Arg 
    1460                 1465                 1470             


Arg Arg  Arg Glu His Gly Ala  Leu Trp Leu Pro Pro  Gly Phe Thr 
    1475                 1480                 1485             


Arg Arg  Pro Arg Thr Gln Ser  Ala Pro His Arg Arg  Arg Pro Pro 
    1490                 1495                 1500             


Leu Gly  Glu Asp Ser Ile Gly  Leu Lys Ala Leu Lys  Pro Lys Ala 
    1505                 1510                 1515             


Glu Val  Asp Glu Asp Gly Val  Val Met Cys Ser Gly  Pro Glu Glu 
    1520                 1525                 1530             


Gly Glu  Glu Val Gly Gln Ala  Glu Glu Thr Gly Pro  Pro Ser Thr 
    1535                 1540                 1545             


Cys Gln  Leu Trp Ser Leu Ser  Gly Gly Cys Gly Ala  Leu Pro Gln 
    1550                 1555                 1560             


Ala Ala  Met Leu Thr Pro Pro  Gln Glu Ser Glu Met  Glu Ala Pro 
    1565                 1570                 1575             


Asp Leu  Asp Thr Arg Gly Pro  Asp Gly Val Thr Pro  Leu Met Ser 
    1580                 1585                 1590             


Ala Val  Cys Cys Gly Glu Val  Gln Ser Gly Thr Phe  Gln Gly Ala 
    1595                 1600                 1605             


Trp Leu  Gly Cys Pro Glu Pro  Trp Glu Pro Leu Leu  Asp Gly Gly 
    1610                 1615                 1620             


Ala Cys  Pro Gln Ala His Thr  Val Gly Thr Gly Glu  Thr Pro Leu 
    1625                 1630                 1635             


His Leu  Ala Ala Arg Phe Ser  Arg Pro Thr Ala Ala  Arg Arg Leu 
    1640                 1645                 1650             


Leu Glu  Ala Gly Ala Asn Pro  Asn Gln Pro Asp Arg  Ala Gly Arg 
    1655                 1660                 1665             


Thr Pro  Leu His Ala Ala Val  Ala Ala Asp Ala Arg  Glu Val Cys 
    1670                 1675                 1680             


Gln Leu  Leu Leu Arg Ser Arg  Gln Thr Ala Val Asp  Ala Arg Thr 
    1685                 1690                 1695             


Glu Asp  Gly Thr Thr Pro Leu  Met Leu Ala Ala Arg  Leu Ala Val 
    1700                 1705                 1710             


Glu Asp  Leu Val Glu Glu Leu  Ile Ala Ala Gln Ala  Asp Val Gly 
    1715                 1720                 1725             


Ala Arg  Asp Lys Trp Gly Lys  Thr Ala Leu His Trp  Ala Ala Ala 
    1730                 1735                 1740             


Val Asn  Asn Ala Arg Ala Ala  Arg Ser Leu Leu Gln  Ala Gly Ala 
    1745                 1750                 1755             


Asp Lys  Asp Ala Gln Asp Asn  Arg Glu Gln Thr Pro  Leu Phe Leu 
    1760                 1765                 1770             


Ala Ala  Arg Glu Gly Ala Val  Glu Val Ala Gln Leu  Leu Leu Gly 
    1775                 1780                 1785             


Leu Gly  Ala Ala Arg Glu Leu  Arg Asp Gln Ala Gly  Leu Ala Pro 
    1790                 1795                 1800             


Ala Asp  Val Ala His Gln Arg  Asn His Trp Asp Leu  Leu Thr Leu 
    1805                 1810                 1815             


Leu Glu  Gly Ala Gly Pro Pro  Glu Ala Arg His Lys  Ala Thr Pro 
    1820                 1825                 1830             


Gly Arg  Glu Ala Gly Pro Phe  Pro Arg Ala Arg Thr  Val Ser Val 
    1835                 1840                 1845             


Ser Val  Pro Pro His Gly Gly  Gly Ala Leu Pro Arg  Cys Arg Thr 
    1850                 1855                 1860             


Leu Ser  Ala Gly Ala Gly Pro  Arg Gly Gly Gly Ala  Cys Leu Gln 
    1865                 1870                 1875             


Ala Arg  Thr Trp Ser Val Asp  Leu Ala Ala Arg Gly  Gly Gly Ala 
    1880                 1885                 1890             


Tyr Ser  His Cys Arg Ser Leu  Ser Gly Val Gly Ala  Gly Gly Gly 
    1895                 1900                 1905             


Pro Thr  Pro Arg Gly Arg Arg  Phe Ser Ala Gly Met  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Asn Pro Ala Ile Met  Arg Gly Arg Tyr Gly  Val Ala Ala 
    1925                 1930                 1935             


Gly Arg  Gly Gly Arg Val Ser  Thr Asp Asp Trp Pro  Cys Asp Trp 
    1940                 1945                 1950             


Val Ala  Leu Gly Ala Cys Gly  Ser Ala Ser Asn Ile  Pro Ile Pro 
    1955                 1960                 1965             


Pro Pro  Cys Leu Thr Pro Ser  Pro Glu Arg Gly Ser  Pro Gln Leu 
    1970                 1975                 1980             


Asp Cys  Gly Pro Pro Ala Leu  Gln Glu Met Pro Ile  Asn Gln Gly 
    1985                 1990                 1995             


Gly Glu  Gly Lys Lys 
    2000             


<210>  1675
<211>  3456
<212>  DNA
<213>  Homosapiens

<400>  1675
aaaagatcca tgggagaagc atggtttcct gaggtcgcac catccctcac ttcttccctt     60

ggctgggagt gggggttcct ttggctctgt gtcgctccca ggggggctgt cgccccatcc    120

agcttttctt tgttctctgt gggtcgagtt gttttcctga tgagtcccaa tgcaagtacc    180

tggatatttc agttgaagat gctgtattca cttgcctctt ttgttcctct ctgccccttt    240

ggtgccagtc tgctggagtt tgctggaggt ccactcctga ccctgtttgc ctgggtatca    300

ccagcagagg ctgcaaagca gcaaagattg ctgcctgttc tttcttctag aagcttcgac    360

ccagtggggc acctgtcaga tgccagccag agctctcctg tatcaggtgt ctgtcggtcc    420

aagctagaag gtatctccca gtcagtatac atggggatca gggacccact tgaggaggca    480

gactgaccct tagcagagct tcaataccgt gctgggaggt ccactgctct cttcagagcc    540

atcaggcagg gacgtttaag tctgctataa gcccccgact ggggttgctg ccttttttac    600

agagatgccc tgtccagaga ggagcaatct ggcagtctgg ccacagcagc cttgctgagc    660

tgcagtgagc tctgcccagt ttgaacttcc cagcagcttt gtttatactg tggccataaa    720

accatctact caagcctcag caatggtgga cgtctcttcc accaccaagc tcaatcatcc    780

caggtgaatc tcagattgct gctgtgctgg cagcaagaat ttcaagccag tggatcttag    840

tttcctgggc tccatggacg tgggaccagc caagccagac cacttggctc cctggcttca    900

gcccctcttt ccaggggagt gaacggttct gtctcgctgg tgttccaggc gccactgggg    960

tatggaaaaa agaaaaaaag ctcctacagc tagttcagtg tctgcccaat tggccaccca   1020

gttttgtgct tgaaacccag ggccctggtg gggtagtcac tggagggaat ctcctggttt   1080

gtgggtttcg aagactgtgg gacaagtgca gtatctgtgc tggagttcct caggctcaga   1140

ccctcatggc ttcccttggg tagaggggaa aattccccga ccccttgcac ttcccaggtg   1200

aggtgatgcc ccaccctgct tcggcttgcc ctccgtgggc tgcacccact gtccaaccag   1260

tcccagtgag atgaaccgtg tgcctcagtt ggaaatgcag aaatcaccca ccttctgcct   1320

cgatctcgct gggagctgca gactggtgct gttcctattc ggccatcttg aatcttgcct   1380

gttcattttt aattttttct ttcagtgtat tttcctctca gttcaggctg gaaaatttca   1440

attgctctat ctttgagttc actgattgtt tcttttgtca tattcattct gttattgaat   1500

ccatccagtg agttttcatt ttggttattt tattttccag ctataaaatt tccatttgct   1560

tctttctttc tttttttttt agaaatgttc atctttttat tttaagttcc ggggtacata   1620

tacaggatgt gcaggtttgt tacataggta aacatgtgcc atgggtagtg ttcatctata   1680

gctctatcaa tgcttcttgt ctttaagtct accttgtttg agagctatgt cagcattctt   1740

ttttttttaa ttatacttta agttctagga tatatatgca caatgtgcag gttagttaca   1800

tgtctataca tgtgccatgt tggtgtgctg cacccattaa ctcgtcattt aacattaggt   1860

atatctccta atgctatccc tcccccctcc gccaacccca caacaggccc tggtgtgtga   1920

tgttcccttt cctgtgtcca tgtgttctca ttgttcaatt cccatctatg agtgagaaca   1980

tgtggtgttt ggttttttgt ccttgcgata gtttgctgag aatgatggtt tccagcttca   2040

tccatgtccc tacaaaggac atgaactcat cattttttat ggctgcatag tattccatgg   2100

tgtatatgtg ccacattttc ttaatccagt ctatcattgt tggacatttg ggttggttcc   2160

aagtctttgc tattgtgaat agtgccacaa taaacatacg tgtgcatgtg tctttatagc   2220

agcacgtttt ataatccttt gggtatatac ccagtaatgg gatggctggg tcaaatggta   2280

tttctagttc tagatccctg aggaatcgcc acactgactt ccacaatggt tgagctagtt   2340

tacagtccca ccaacagtgt aaaagtgttc ctatttctcc acatcctctc cagcacctgt   2400

tgtttcctga ctttttaatg attgccattc taactagtgt gagatggaat ctcattgtgg   2460

ttttgatttg catttctccg atggccagtg atgatgagca ttttttcatg tgtcttttgg   2520

ctgtgtaaat gtcttctttt gagaagtgtc tgttcatatc cttcgcccac ttgttgatgg   2580

ggttgtttgt ttttttcttg taaatttgtt tgagttcatt gtagattctg gatattagcc   2640

ctttgtcaga tgagtagatg caaaaatttt ctcccattct gtaggttgcc tgttcactct   2700

gatggtagtt tcttttgctg tgcagaagct ctttagttta attagatccc atttgtcgat   2760

tttggcattt gttgccattg cttttggtgt tttagacatg aagtccttgc ccatgcctat   2820

gtcctgaatg gtgttgccta ggttttcttc tagggttttt atggttttag gtctaacatt   2880

taagaggata caaacaaatg gaagaacatt ccatgctcat gggtaggaag aatcaatatc   2940

gtgaaaatgg ccatactgcc caaggtaatt tatagattca atgccatccc catcaagcta   3000

ccaatgactt tcttcacaga attggaaaaa actactttaa agttcatatg gaaccaaaaa   3060

agagcccaca ttgccaagtc agtcctaagc caaaagaaca aagctggagg catcacgcta   3120

cctgacttca aactatacta caaggctaca gtaaccaaaa cagcatggta ctggtaccaa   3180

aacagagata tagaccctca gaaataatgc cacatatcta caactatctg atctttgaca   3240

aacctgacaa aaacaagaaa tggggaaagg attccctatt tagtaaatgg tgctgggaaa   3300

actggctagc catatgtaga aagctgaaaa tggatccctt ccttacacct tatacaaaga   3360

ttaattcaag atggattaaa gacttaagtg cttctttctt atattttata tttgttgcta   3420

agatgttcca ttaaaaataa tttcgaagtt attcat                             3456


<210>  1676
<211>  158
<212>  PRT
<213>  Homosapiens

<400>  1676

Met Gly Glu Ala Trp Phe Pro Glu Val Ala Pro Ser Leu Thr Ser Ser 
1               5                   10                  15      


Leu Gly Trp Glu Trp Gly Phe Leu Trp Leu Cys Val Ala Pro Arg Gly 
            20                  25                  30          


Ala Val Ala Pro Ser Ser Phe Ser Leu Phe Ser Val Gly Arg Val Val 
        35                  40                  45              


Phe Leu Met Ser Pro Asn Ala Ser Thr Trp Ile Phe Gln Leu Lys Met 
    50                  55                  60                  


Leu Tyr Ser Leu Ala Ser Phe Val Pro Leu Cys Pro Phe Gly Ala Ser 
65                  70                  75                  80  


Leu Leu Glu Phe Ala Gly Gly Pro Leu Leu Thr Leu Phe Ala Trp Val 
                85                  90                  95      


Ser Pro Ala Glu Ala Ala Lys Gln Gln Arg Leu Leu Pro Val Leu Ser 
            100                 105                 110         


Ser Arg Ser Phe Asp Pro Val Gly His Leu Ser Asp Ala Ser Gln Ser 
        115                 120                 125             


Ser Pro Val Ser Gly Val Cys Arg Ser Lys Leu Glu Gly Ile Ser Gln 
    130                 135                 140                 


Ser Val Tyr Met Gly Ile Arg Asp Pro Leu Glu Glu Ala Asp 
145                 150                 155             


<210>  1677
<211>  2222
<212>  DNA
<213>  Homosapiens

<400>  1677
ctgctccaca caatttctca gtgatcctct gcatctctgc ctacaagggc ctccctgaca     60

cccaagttca tattgctcag aaacagtgaa cttgagtttt tcgttttatc ttgatctctc    120

tctgacaaag aaatccagat gatgcgagac ctgatgaaga caatacatgg aaaatgacag    180

tcttggaaat aactttggct gtcatcctga ctctactggg acttgccatc ctggctattt    240

tgttaacaag atgggcacga cgtaagcaaa gtgaaatgca tatctccaga tacagttcag    300

aacaaagtgc tagacttctg gactatgagg atggtagagg atcccgacat gcatattcaa    360

cacaaagtga cacttcatgt gataaccgag agagatccaa aagagattac acaccatcaa    420

ccaactctct agtgtctatg gcatctaagt tctccctggg acaaacagaa ctcattcttc    480

ttttgatgtg ttttatttta gcactgtctc gatcaagtat tggtagtata aaatgtttac    540

aaacaactga agaacttcct tccagaactg caggagccat gatgcaattc acagccccta    600

ttcccggagc tacaggacct atcaagctct ctcaaaaaac cattgtgcaa actccaggac    660

ctattgtaca atatcctgga cccaatgctg gtccaccttc agcaccccgc ggtccaccca    720

tggcacccat aataatttca cagagaaccg caagaatacc tcaagttcac actatggaca    780

gttctggaaa aatcacactg actcctgtgg ttatattaac aggttacatg gatgaagaac    840

ttgcaaaaaa accttgttcc aaaatccaga ttctaaaatg tggaggcact gcaaggtctc    900

agaatagccg agaagaaaac aaggaagcac taaagaatga catcatattt acgaattctg    960

tagaatcctt gaaatcagca cacataaagg agccagaaag agaaggaaaa ggcactgatt   1020

tagagaaaga caaaatagga atggaggtca aggtagacag tgacgctgga ataccaaaaa   1080

gacaggaaac ccaactaaaa atcagtgaga tgagtatacc acaaggacag ggagcccaaa   1140

taaagaaaag tgtgtcagat gtaccaagag gacaggagtc ccaagtaaag aagagtgagt   1200

caggtgtccc aaaaggacaa gaagcccaag taacgaagag tgggttggtt gtactgaaag   1260

gacaggaagc ccaggtagag aagagtgaga tgggtgtgcc aagaagacag gaatcccaag   1320

taaagaagag tcagtctggt gtctcaaagg gacaggaagc ccaggtaaag aagagggagt   1380

cagttgtact gaaaggacag gaagcccagg tagagaagag tgagttgaag gtaccaaaag   1440

gacaagaagg ccaagtagag aagactgagg cagatgtgcc aaaggaacaa gaggtccaag   1500

aaaagaagag tgaggcaggt gtactgaaag gaccagaatc ccaagtaaag aacactgagg   1560

tgagtgtacc agaaacactg gaatcccaag taaagaagag tgagtcaggt gtactaaaag   1620

gacaggaagc ccaagaaaag aaggagagtt ttgaggataa aggaaataat gataaagaaa   1680

aggagagaga tgcagagaaa gatccaaata aaaaagaaaa aggtgacaaa aacacaaaag   1740

gtgacaaagg aaaggacaaa gttaaaggaa agagagaatc agaaatcaat ggtgaaaaat   1800

caaaaggctc gaaaagggcg aaggcaaata caggaaggaa gtacaacaaa aaagtggaag   1860

agtaaggata aattttttaa aggcccataa gacaagtgat tattatgatt cccatactcc   1920

agatacaaac catatcccag ccattgccta aacagattac aattataaaa tccctttcat   1980

cttcatatca cagtttctgc tcttcagaag tttcaccctt tttaatctct cagccacaaa   2040

cctcagtttc caaatatttg tttcataagt taagacgtat atgattccgt caagaaagac   2100

tggatacttt ctgaagtaaa acattttaat taaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2160

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2220

aa                                                                  2222


<210>  1678
<211>  563
<212>  PRT
<213>  Homosapiens

<400>  1678

Met Thr Val Leu Glu Ile Thr Leu Ala Val Ile Leu Thr Leu Leu Gly 
1               5                   10                  15      


Leu Ala Ile Leu Ala Ile Leu Leu Thr Arg Trp Ala Arg Arg Lys Gln 
            20                  25                  30          


Ser Glu Met His Ile Ser Arg Tyr Ser Ser Glu Gln Ser Ala Arg Leu 
        35                  40                  45              


Leu Asp Tyr Glu Asp Gly Arg Gly Ser Arg His Ala Tyr Ser Thr Gln 
    50                  55                  60                  


Ser Asp Thr Ser Cys Asp Asn Arg Glu Arg Ser Lys Arg Asp Tyr Thr 
65                  70                  75                  80  


Pro Ser Thr Asn Ser Leu Val Ser Met Ala Ser Lys Phe Ser Leu Gly 
                85                  90                  95      


Gln Thr Glu Leu Ile Leu Leu Leu Met Cys Phe Ile Leu Ala Leu Ser 
            100                 105                 110         


Arg Ser Ser Ile Gly Ser Ile Lys Cys Leu Gln Thr Thr Glu Glu Leu 
        115                 120                 125             


Pro Ser Arg Thr Ala Gly Ala Met Met Gln Phe Thr Ala Pro Ile Pro 
    130                 135                 140                 


Gly Ala Thr Gly Pro Ile Lys Leu Ser Gln Lys Thr Ile Val Gln Thr 
145                 150                 155                 160 


Pro Gly Pro Ile Val Gln Tyr Pro Gly Pro Asn Ala Gly Pro Pro Ser 
                165                 170                 175     


Ala Pro Arg Gly Pro Pro Met Ala Pro Ile Ile Ile Ser Gln Arg Thr 
            180                 185                 190         


Ala Arg Ile Pro Gln Val His Thr Met Asp Ser Ser Gly Lys Ile Thr 
        195                 200                 205             


Leu Thr Pro Val Val Ile Leu Thr Gly Tyr Met Asp Glu Glu Leu Ala 
    210                 215                 220                 


Lys Lys Pro Cys Ser Lys Ile Gln Ile Leu Lys Cys Gly Gly Thr Ala 
225                 230                 235                 240 


Arg Ser Gln Asn Ser Arg Glu Glu Asn Lys Glu Ala Leu Lys Asn Asp 
                245                 250                 255     


Ile Ile Phe Thr Asn Ser Val Glu Ser Leu Lys Ser Ala His Ile Lys 
            260                 265                 270         


Glu Pro Glu Arg Glu Gly Lys Gly Thr Asp Leu Glu Lys Asp Lys Ile 
        275                 280                 285             


Gly Met Glu Val Lys Val Asp Ser Asp Ala Gly Ile Pro Lys Arg Gln 
    290                 295                 300                 


Glu Thr Gln Leu Lys Ile Ser Glu Met Ser Ile Pro Gln Gly Gln Gly 
305                 310                 315                 320 


Ala Gln Ile Lys Lys Ser Val Ser Asp Val Pro Arg Gly Gln Glu Ser 
                325                 330                 335     


Gln Val Lys Lys Ser Glu Ser Gly Val Pro Lys Gly Gln Glu Ala Gln 
            340                 345                 350         


Val Thr Lys Ser Gly Leu Val Val Leu Lys Gly Gln Glu Ala Gln Val 
        355                 360                 365             


Glu Lys Ser Glu Met Gly Val Pro Arg Arg Gln Glu Ser Gln Val Lys 
    370                 375                 380                 


Lys Ser Gln Ser Gly Val Ser Lys Gly Gln Glu Ala Gln Val Lys Lys 
385                 390                 395                 400 


Arg Glu Ser Val Val Leu Lys Gly Gln Glu Ala Gln Val Glu Lys Ser 
                405                 410                 415     


Glu Leu Lys Val Pro Lys Gly Gln Glu Gly Gln Val Glu Lys Thr Glu 
            420                 425                 430         


Ala Asp Val Pro Lys Glu Gln Glu Val Gln Glu Lys Lys Ser Glu Ala 
        435                 440                 445             


Gly Val Leu Lys Gly Pro Glu Ser Gln Val Lys Asn Thr Glu Val Ser 
    450                 455                 460                 


Val Pro Glu Thr Leu Glu Ser Gln Val Lys Lys Ser Glu Ser Gly Val 
465                 470                 475                 480 


Leu Lys Gly Gln Glu Ala Gln Glu Lys Lys Glu Ser Phe Glu Asp Lys 
                485                 490                 495     


Gly Asn Asn Asp Lys Glu Lys Glu Arg Asp Ala Glu Lys Asp Pro Asn 
            500                 505                 510         


Lys Lys Glu Lys Gly Asp Lys Asn Thr Lys Gly Asp Lys Gly Lys Asp 
        515                 520                 525             


Lys Val Lys Gly Lys Arg Glu Ser Glu Ile Asn Gly Glu Lys Ser Lys 
    530                 535                 540                 


Gly Ser Lys Arg Ala Lys Ala Asn Thr Gly Arg Lys Tyr Asn Lys Lys 
545                 550                 555                 560 


Val Glu Glu 
            


<210>  1679
<211>  1368
<212>  DNA
<213>  Homosapiens

<400>  1679
atggtggatt ttccaggcta caatctgtct ggtgcagtcg cctccttcct attcatcctg     60

ctgacaatga agcagtcaga agactttaga gtcattggcc ctgctcatcc tatcctggcc    120

ggggttgggg aagatgccct gttaacctgc cagctactcc ccaagaggac cacaatgcac    180

gtggaggtga ggtggtaccg ctcagagccc agcacacctg tgtttgtgca cagggatgga    240

gtggaggtga ctgagatgca gatggaggag tacagaggct gggtagagtg gatagagaat    300

ggcattgcaa agggaaatgt ggcactgaag atacacaaca tccagccctc cgacaatgga    360

caatactggt gccatttcca ggatgggaac tactgtggag aaacaagctt gctgctcaaa    420

gtagcaggtc tggggtctgc ccctagcatc cacatggagg gacctgggga gagtggagtc    480

cagcttgtgt gcactgcaag gggctggttc ccagagcccc aggtgtattg ggaagacatc    540

cggggagaga agctgctggc cgtgtctgag catcgcatcc aagataaaga tggcctgttc    600

tatgcggaag ccaccctggt ggtcaggaac gcctctgcag agtctgtgtc ctgcttggtc    660

cacaaccccg tcctcactga ggagaagggg tcggtcatca gcctcccaga gaaactccag    720

actgagctgg cttctttaaa agtgaatgga ccttcccagc ccatcctcgt cagagtggga    780

gaagatatac agctaacctg ttacctgtcc cccaaggcga atgcacagag catggaggtg    840

aggtgggacc gatcccaccg ttaccctgct gtgcatgtgt atatggatgg ggaccatgtg    900

gctggagagc agatggcaga gtacagaggg aggactgtac tggtgagtga cgccattgac    960

gagggcagac tgaccctgca gatactcagt gccagacctt cggacgacgg gcagtaccgc   1020

tgcctttttg aaaaagatga tgtctaccag gaggccagtt tggatctgaa ggtggtaagt   1080

ctgggttctt ccccactgat cactgtggag gggcaagaag atggagaaat gcagccgatg   1140

tgctcttcag atgggtggtt cccacagccc cacgtgccat ggagggacat ggaaggaaag   1200

acgataccat catcttccca ggccctgact caaggcagcc acgggctgtt ccacgtgcag   1260

acattgctaa gggtcacaaa catctccgct gtggacgtca cttgttccat cagcatcccc   1320

tttttgggcg aggagaaaat cgcaactttt tctctctcag gttggtga                1368


<210>  1680
<211>  455
<212>  PRT
<213>  Homosapiens

<400>  1680

Met Val Asp Phe Pro Gly Tyr Asn Leu Ser Gly Ala Val Ala Ser Phe 
1               5                   10                  15      


Leu Phe Ile Leu Leu Thr Met Lys Gln Ser Glu Asp Phe Arg Val Ile 
            20                  25                  30          


Gly Pro Ala His Pro Ile Leu Ala Gly Val Gly Glu Asp Ala Leu Leu 
        35                  40                  45              


Thr Cys Gln Leu Leu Pro Lys Arg Thr Thr Met His Val Glu Val Arg 
    50                  55                  60                  


Trp Tyr Arg Ser Glu Pro Ser Thr Pro Val Phe Val His Arg Asp Gly 
65                  70                  75                  80  


Val Glu Val Thr Glu Met Gln Met Glu Glu Tyr Arg Gly Trp Val Glu 
                85                  90                  95      


Trp Ile Glu Asn Gly Ile Ala Lys Gly Asn Val Ala Leu Lys Ile His 
            100                 105                 110         


Asn Ile Gln Pro Ser Asp Asn Gly Gln Tyr Trp Cys His Phe Gln Asp 
        115                 120                 125             


Gly Asn Tyr Cys Gly Glu Thr Ser Leu Leu Leu Lys Val Ala Gly Leu 
    130                 135                 140                 


Gly Ser Ala Pro Ser Ile His Met Glu Gly Pro Gly Glu Ser Gly Val 
145                 150                 155                 160 


Gln Leu Val Cys Thr Ala Arg Gly Trp Phe Pro Glu Pro Gln Val Tyr 
                165                 170                 175     


Trp Glu Asp Ile Arg Gly Glu Lys Leu Leu Ala Val Ser Glu His Arg 
            180                 185                 190         


Ile Gln Asp Lys Asp Gly Leu Phe Tyr Ala Glu Ala Thr Leu Val Val 
        195                 200                 205             


Arg Asn Ala Ser Ala Glu Ser Val Ser Cys Leu Val His Asn Pro Val 
    210                 215                 220                 


Leu Thr Glu Glu Lys Gly Ser Val Ile Ser Leu Pro Glu Lys Leu Gln 
225                 230                 235                 240 


Thr Glu Leu Ala Ser Leu Lys Val Asn Gly Pro Ser Gln Pro Ile Leu 
                245                 250                 255     


Val Arg Val Gly Glu Asp Ile Gln Leu Thr Cys Tyr Leu Ser Pro Lys 
            260                 265                 270         


Ala Asn Ala Gln Ser Met Glu Val Arg Trp Asp Arg Ser His Arg Tyr 
        275                 280                 285             


Pro Ala Val His Val Tyr Met Asp Gly Asp His Val Ala Gly Glu Gln 
    290                 295                 300                 


Met Ala Glu Tyr Arg Gly Arg Thr Val Leu Val Ser Asp Ala Ile Asp 
305                 310                 315                 320 


Glu Gly Arg Leu Thr Leu Gln Ile Leu Ser Ala Arg Pro Ser Asp Asp 
                325                 330                 335     


Gly Gln Tyr Arg Cys Leu Phe Glu Lys Asp Asp Val Tyr Gln Glu Ala 
            340                 345                 350         


Ser Leu Asp Leu Lys Val Val Ser Leu Gly Ser Ser Pro Leu Ile Thr 
        355                 360                 365             


Val Glu Gly Gln Glu Asp Gly Glu Met Gln Pro Met Cys Ser Ser Asp 
    370                 375                 380                 


Gly Trp Phe Pro Gln Pro His Val Pro Trp Arg Asp Met Glu Gly Lys 
385                 390                 395                 400 


Thr Ile Pro Ser Ser Ser Gln Ala Leu Thr Gln Gly Ser His Gly Leu 
                405                 410                 415     


Phe His Val Gln Thr Leu Leu Arg Val Thr Asn Ile Ser Ala Val Asp 
            420                 425                 430         


Val Thr Cys Ser Ile Ser Ile Pro Phe Leu Gly Glu Glu Lys Ile Ala 
        435                 440                 445             


Thr Phe Ser Leu Ser Gly Trp 
    450                 455 


<210>  1681
<211>  1267
<212>  DNA
<213>  Homosapiens

<400>  1681
acattctctt ttcttttatt cttgtctgtt ctgcctcact cccgagctct actgactccc     60

aacagagcgc ccaagaagaa aatggccata agtggagtcc ctgtgctagg atttttcatc    120

atagctgtgc tgatgagcgc tcaggaatca tgggctatca aagaagaaca tgtgatcatc    180

caggccgagt tctatctgaa tcctgaccaa tcaggcgagt ttatgtttga ctttgatggt    240

gatgagattt tccatgtgga tatggcaaag aaggagacgg tctggcggct tgaagaattt    300

ggacgatttg ccagctttga ggctcaaggt gcattggcca acatagctgt ggacaaagcc    360

aacctggaaa tcatgacaaa gcgctccaac tatactccga tcaccaatgt acctccagag    420

gtaactgtgc tcacgaacag ccctgtggaa ctgagagagc ccaacgtcct catctgtttc    480

atagacaagt tcaccccacc agtggtcaat gtcacgtggc ttcgaaatgg aaaacctgtc    540

accacaggag tgtcagagac agtcttcctg cccagggaag accacctttt ccgcaagttc    600

cactatctcc ccttcctgcc ctcaactgag gacgtttacg actgcagggt ggagcactgg    660

ggcttggatg agcctcttct caagcactgg gagtttgatg ctccaagccc tctcccagag    720

actacagaga acgtggtgtg tgccctgggc ctgactgtgg gtctggtggg catcattatt    780

gggaccatct tcatcatcaa gggattgcgc aaaagcaatg cagcagaacg cagggggcct    840

ctgtaaggca catggaggtg atggtgtttc ttagagagaa gatcactgaa gaaacttctg    900

ctttaatggc tttacaaagc tggcaatatt acaatccttg acctcagtga aagcagtcat    960

cttcagcatt ttccagccct atagccaccc caagtgtgga tatgcctctt cgattgctcc   1020

gtactctaac atctagctgg cttccctgtc tattgccttt tcctgtatct attttcctct   1080

atttcctatc attttattat caccatgcaa tgcctctgga ataaaacata caggagtctg   1140

tctctgctat ggaatgcccc atggggcatc tcttgtgtac ttattgttta aggtttcctc   1200

aaactgtgat ttttctgaac acaataaact attttgatga tcttgggtgg aaaaaaaaaa   1260

aaaaaaa                                                             1267


<210>  1682
<211>  254
<212>  PRT
<213>  Homosapiens

<400>  1682

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Leu Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210>  1683
<211>  1171
<212>  DNA
<213>  Homosapiens

<400>  1683
ccagcatggt gtgtctgaag ctccctggag gttcctacat ggcaaagctg acagtgacac     60

tgatggtgct gagctcccca ctggctttgg ctggggacac ccgaccacgt ttcttgcagc    120

aggataagta tgagtgtcat ttcttcaacg ggacggagcg ggtgcggttc ctgcacagag    180

acatctataa ccaagaggag gacttgcgct tcgacagcga cgtgggggag taccgggcgg    240

tgacggagct ggggcggcct gacgctgagt actggaacag ccagaaggac ttcctggaag    300

acaggcgcgc cgcggtggac acctactgca gacacaacta cggggttggt gagagcttca    360

cagtgcagcg gcgagttgag cctaaggtga ctgtgtatcc tgcaaggacc cagaccctgc    420

agcaccacaa cctcctggtc tgctctgtga atggtttcta tccaggcagc attgaagtca    480

ggtggttccg gaacagccag gaagagaagg ctggggtggt gtccacaggc ctgattcaga    540

atggagactg gaccttccag accctggtga tgctggaaac agttcctcga agtggagagg    600

tttacacctg ccaagtggag cacccaagcg tgacgagccc tctcacagtg gaatggagag    660

cacagtctga atctgcacag agcaagatgc tgagtggagt cgggggcttt gtgctgggcc    720

tgctcttcct tggggccggg ctattcatct acttcaagaa tcagaaaggg cactctggac    780

ttcacccaac aggactcgtg agctgaagtg cagatgacca cattcaaggg ggaaccttct    840

gccccagctt tgcatgatga aaagctttcc tgcttggctc ttattcttcc acaagagagg    900

actttctcag gccctggttg ctaccggttc agcaactctg cagaaaatgt ccatccttgt    960

ggcttcctca gctcctgccc ttggcctgaa gtcccagcat tgatggcagt gcctcatctt   1020

caactttagt gctccccttt acctaaccct acggcctccc atgcatctgt actccccctg   1080

tgtgccacaa atgcactacg ttattaaatt tttctgaagc ccagagttaa aaatcatctg   1140

tccacctggc tccaaagaca aaaaataaaa a                                  1171


<210>  1684
<211>  266
<212>  PRT
<213>  Homosapiens

<400>  1684

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Tyr Met Ala Lys Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Gln Gln Asp Lys Tyr Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu His Arg Asp Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Asp Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Arg Thr Gln Thr Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Lys Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu His Pro Thr Gly Leu Val Ser 
            260                 265     


<210>  1685
<211>  1235
<212>  DNA
<213>  Homosapiens

<400>  1685
gaatacagaa tgtgggcaaa ctcgcttctg tgccggccgc cagaaggttt gctgagggca     60

atcactccct ggtgccgggc tccttgaggt tatgcactgg gacatctaga gcctattgtt    120

tgaggaatgc agtcttgcaa gcctgctctg gatcaagcca cagactgaaa cacccccgaa    180

gagcaagcac gtttcttgga gcaggctaag tgtgagtgtc atatcttcaa tgggatgaag    240

cgggtgcagt acctgaacag atacatccat aaacgggagg agaacctgcg cttcgacagc    300

aacgtggagg agttccaggc agttacggaa ctggggcggc ctgtcgcaga gaactggaac    360

agccagaagg gcatcccgga ggagaagcgg gacaagatgg acgactactg cagatacaat    420

tacggggttt tttgagagct tcacagtgca gccgcgagtc catcctaagg tgactgtgta    480

tcctgcaaag acccagcccc tgcatcaccg caaccccctg gtcggctctg tgagtggttt    540

ctatccaggc agcattaaag tcaggtggtt ccagaatggt caggaagaga aggctgcggt    600

ggtctccata ggcctgatcc agaatggaga ttggaccttc cagaccctgg tgatgctgga    660

aacagttcct cggagtggag aggtttacac ctgccaagtg gagcatccaa gcgtgacgag    720

ccctctcaca gtggaatgga gtacacggac tgaatctgca cagagcaaga tgctgagtgg    780

agtcgggggc tttgtgctgg gcctgctctt ccttgggaca gggctgttca tctacttcag    840

gaatcagaaa ggacactctg gacttcagcc aacaggactc ctgcgctgga ctcctgagct    900

gaagtgcaca tgaccacatt caaggaagaa ccttctgcca cagctttgca ggatgaaaag    960

ctttcccact tggctcttat tcttccacaa gagctctctc aggaccaggt tgttactcgt   1020

tcagcaactc tgcagaaaat gccctccctt gtggcttcct cagctcctgt tcttggcctg   1080

aaaccccaca gccttgatgg cagcgcctcg tcttcaactt ttgtgcttcc ttttacctaa   1140

attttcctgc ctcccctggg tctgtattcc ccttgtgcca caaacacatt gcattattca   1200

atgtttctca aacatggagt taaaaattat ctggt                              1235


<210>  1686
<211>  1182
<212>  DNA
<213>  Homosapiens

<400>  1686
tagttctccc tgagtgagac ttgcctgctt ctctggcccc tggtcctgtc ctgttctcca     60

gcatggtgtg tctgaagctc cctggaggct cctgcatgac agcgctgaca gtgacactga    120

tggtgctgag ctccccactg gctttggctg gggacacccg accacgtttc ttgtggcagc    180

ttaagtttga atgtcatttc ttcaatggga cggagcgggt gcggttgctg gaaagatgca    240

tctataacca agaggagtcc gtgcgcttcg acagcgacgt gggggagtac cgggcggtga    300

cggagctggg gcggcctgat gccgagtact ggaacagcca gaaggacctc ctggagcaga    360

ggcgggccgc ggtggacacc tactgcagac acaactacgg ggttggtgag agcttcacag    420

tgcagcggcg agttgagcct aaggtgactg tgtatccttc aaagacccag cccctgcagc    480

accacaacct cctggtctgc tctgtgagtg gtttctatcc aggcagcatt gaagtcaggt    540

ggttccggaa cggccaggaa gagaaggctg gggtggtgtc cacaggcctg atccagaatg    600

gagattggac cttccagacc ctggtgatgc tggaaacagt tcctcggagt ggagaggttt    660

acacctgcca agtggagcac ccaagtgtga cgagccctct cacagtggaa tggagagcac    720

ggtctgaatc tgcacagagc aagatgctga gtggagtcgg gggcttcgtg ctgggcctgc    780

tcttccttgg ggccgggctg ttcatctact tcaggaatca gaaaggacac tctggacttc    840

agccaacagg attcctgagc tgaaatgcag atgaccacat tcaaggaaga accttctgtc    900

ccagctttgc agaatgaaaa gctttcctgc ttggcagtta ttcttccaca agagagggct    960

ttctcaggac ctggttgcta ctggttcggc aactgcagaa aatgtcctcc cttgtggctt   1020

cctcagctcc tgcccttggc ctgaagtccc agcattgatg acagcgcctc atcttcaact   1080

tttgtgctcc cctttgccta aaccgtatgg cctcccgtgc atctgtactc accctgtacg   1140

acaaacacat tacattatta aatgtttctc aaagatggag tt                      1182


<210>  1687
<211>  266
<212>  PRT
<213>  Homosapiens

<400>  1687

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  1688
<211>  1542
<212>  DNA
<213>  Homosapiens

<400>  1688
acaattactc tacagctcag aacaccaact gctgaggctg ccttgggaag aggatgatcc     60

taaacaaagc tctgctgctg ggggccctcg ctctgaccac cgtgatgagc ccctgtggag    120

gtgaagacat tgtggctgac cacgttgcct cttgtggtgt aaacttgtac cagttttacg    180

gtccctctgg ccagtacacc catgaatttg atggagatga gcagttctac gtggacctgg    240

agaggaagga gactgcctgg cggtggcctg agttcagcaa atttggaggt tttgacccgc    300

agggtgcact gagaaacatg gctgtggcaa aacacaactt gaacatcatg attaaacgct    360

acaactctac cgctgctacc aatgaggttc ctgaggtcac agtgttttcc aagtctcccg    420

tgacactggg tcagcccaac accctcattt gtcttgtgga caacatcttt cctcctgtgg    480

tcaacatcac atggctgagc aatgggcagt cagtcacaga aggtgtttct gagaccagct    540

tcctctccaa gagtgatcat tccttcttca agatcagtta cctcaccttc ctcccttctg    600

ctgatgagat ttatgactgc aaggtggagc actggggcct ggaccagcct cttctgaaac    660

actgggagcc tgagattcca gcccctatgt cagagctcac agagactgtg gtctgtgccc    720

tggggttgtc tgtgggcctc atgggcattg tggtgggcac tgtcttcatc atccaaggcc    780

tgcgttcagt tggtgcttcc agacaccaag ggccattgtg aatcccatcc tggaagggaa    840

ggtgcatcgc catctacagg agcagaagaa tggacttgct aaatgaccta gcactattct    900

ctggcccgat ttatcatatc ccttttctcc tccaaatatt tctcctctca ccttttctct    960

gggacttaag ctgctatatc ccctcagagc tcacaaatgc ctttacattc tttccctgac   1020

ctcctgattt tttttttctt ttctcaaatg ttacctacaa agacatgcct ggggtaagcc   1080

acccggctac ctaattcctc agtaacctcc atctaaaatc tccaaggaag caataaattc   1140

cttttatgag atctatgtca aatttttcca tctttcatcc agggctgact gaaactatgg   1200

ctaataattg gggtactctt atgtttcaat ccaatttaac ctcatttccc agatcatttt   1260

tcatgtccag taacacagaa gccaccaagt acagtatagc ctgataatat gttgatttct   1320

tagctgacat taatatttct tgcttccttg tgttcccacc cttggcactg ccacccaccc   1380

ctcaattcag gcaacaatga aattaatgga taccgtctgc ccttggccca gaattgttat   1440

agcaaaaatt ttagaaccaa aaaataagtc tgtactaatt tcaatgtggc ttttaaaagt   1500

atgacagaga aataagttag gataaaggaa atttgaatct ca                      1542


<210>  1689
<211>  255
<212>  PRT
<213>  Homosapiens

<400>  1689

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  1690
<211>  1190
<212>  DNA
<213>  Homosapiens

<400>  1690
cagatccatc aggtccgagc tgtgttgact accacttttc ccttcgtctc aattatgtct     60

tggaaaaagg ctttgcggat ccccggaggc cttcgggcag caactgtgac cttgatgctg    120

tcgatgctga gcaccccagt ggctgagggc agagactctc ccgaggattt cgtgtaccag    180

tttaagggca tgtgctactt caccaacggg acagagcgcg tgcgtcttgt gagcagaagc    240

atctataacc gagaagagat cgtgcgcttc gacagcgacg tgggggagtt ccgggcggtg    300

acgctgctgg ggctgcctgc cgccgagtac tggaacagcc agaaggacat cctggagagg    360

aaacgggcgg cggtggacag ggtgtgcaga cacaactacc agttggagct ccgcacgacc    420

ttgcagcggc gagtggagcc cacagtgacc atctccccat ccaggacaga ggccctcaac    480

caccacaacc tgctggtctg ctcggtgaca gatttctatc cagcccagat caaagtccgg    540

tggtttcgga atgaccagga ggagacagct ggcgttgtgt ccacccccct tattaggaat    600

ggtgactgga ccttccagat cctggtgatg ctggaaatga ctccccagcg tggagacgtc    660

tacacctgcc acgtggagca ccccagcctc cagagcccca tcaccgtgga gtggcgggct    720

caatctgaat ctgcccagag caagatgctg agtggcattg gaggcttcgt gctggggctg    780

atcttcctcg ggctgggcct tatcatccat cacaggagtc agaaagggct cctgcactga    840

ctcctgagac tattttaact gggattggtt atcacttttc tgtaacgcct gcttgtccct    900

gcccagaatt cccagctgtc tgtgtcagcc tgtccccctg agatcagagt cctacagtgg    960

ctgtcacgca gccaccaggt catctccttt catccccacc ttgaggcgga tggctgtgac   1020

cctacttcct gcactgaccc acagcctctg cctgtgcacg gccagctgca tctactcagg   1080

ccccaagggg tttctgtttc tattctctcc tcagactgct caagagaagc acatgaaaac   1140

cattacctga ctttagagct tttttacata attaaacatg atcctgagtt              1190


<210>  1691
<211>  261
<212>  PRT
<213>  Homosapiens

<400>  1691

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ser Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Ser Arg Ser Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Ile Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg 
65                  70                  75                  80  


Ala Val Thr Leu Leu Gly Leu Pro Ala Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Asp Ile Leu Glu Arg Lys Arg Ala Ala Val Asp Arg Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  1692
<211>  1709
<212>  DNA
<213>  Homosapiens

<400>  1692
tcctcacaat tgctctacag ctcagagcag caactgctga ggctgccttg ggaagaagat     60

gatcctaaac aaagctctgc tgctgggggc cctcgccctg actgccgtga tgagcccctg    120

tggaggtgaa gacattgtgg ctgaccatgt tgcctcctat ggtgtgaact tctaccagtc    180

tcacggtccc tctggccagt acacccatga atttgatgga gacgaggagt tctacgtgga    240

cctggagacg aaagagactg tctggcagtt gcctatgttt agcaaattta taagttttga    300

cccgcagagt gcactgagaa atatggctgt gggaaaacac accttggaat tcatgatgag    360

acagtccaac tctaccgctg ccaccaatga ggttcctgag gtcacagtgt tttccaagtt    420

tcctgtgacg ctgggtcagc ccaacaccct catctgtctt gtggacaaca tctttcctcc    480

tgtggtcaac atcacctggc tgagcaatgg gcactcagtc acagaaggtg tttctgagac    540

cagcttcctc tccaagagtg atcattcctt cttcaagatc agttacctca ccttcctccc    600

ttctgctgat gagatttatg actgcaaggt ggagcactgg ggcctggacg agcctcttct    660

gaaacactgg gagcctgaga ttccagcccc tatgtcagag ctcacagaga ctttggtctg    720

cgccctgggg ttgtctgtgg gcctcatggg cattgtggtg ggcactgtct tcatcatcca    780

aggcctgcgt tcagttggtg cttccagaca ccaagggctc ttatgaatct catcctgaaa    840

ggaaggtgca tcaccatcta caggagaaga agaatggact tgctaaatga cctagcacta    900

ttctctggcc tgatttatca tatccctttt ctcctccaaa tgtttcttct ctcacctctt    960

ctctgggact taaggtgcta tattccctca gagctcacaa atgcctttca attctttccc   1020

tgacctcctt tcctgaattt ttttattttc tcaaatgtta cctactaagg gatgcctgag   1080

taagccactc agctacctaa ttcctcaatg acctttatct aaaatctcca tggaagcaat   1140

aaattccctt ttgatgcctc tattgaattt ttcccatctt tcatctcagg gctgactgag   1200

agcataactt agaatgggtg actcttatgt tttaggccaa tttcatgtca ttccccagat   1260

catatttcat gtccagtaac acaggagcaa ccaagtacag tgtatcctga taatttgttg   1320

atttcttaac tggtgttaat atttctttct tccttttgtt cctacccttg gccactgcca   1380

cccacccctc aattcaggta ccaacgaacc ctctgccctt ggctcagaat ggttatagca   1440

gaaatacaaa aaaaaaaaaa aaagtctgta ctaatttcaa tatggctctt aaaaggaatg   1500

acagagaaat aggatacaag aattttgaat ctcaaaagtt atcaaaagta aaaaattttg   1560

ttaccaaaag tcaaactgca ttctcaaaac tttaaatttg tgaagaatga caacagtaga   1620

agctttcctc tccccttctc accttgagga gataaaaatt ctctaggcag gaaaagaaat   1680

ggaagccagt tagaaaaaca ttgaaataa                                     1709


<210>  1693
<211>  255
<212>  PRT
<213>  Homosapiens

<400>  1693

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Ala 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Phe Tyr Gln Ser His Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Thr 
    50                  55                  60                  


Lys Glu Thr Val Trp Gln Leu Pro Met Phe Ser Lys Phe Ile Ser Phe 
65                  70                  75                  80  


Asp Pro Gln Ser Ala Leu Arg Asn Met Ala Val Gly Lys His Thr Leu 
                85                  90                  95      


Glu Phe Met Met Arg Gln Ser Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Phe Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Leu Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Leu Leu 
                245                 250                 255 


<210>  1694
<211>  1092
<212>  DNA
<213>  Homosapiens

<400>  1694
tctcacttat gtcttggaag atggctctgc agatccctgg aggcttttgg gcagcagctg     60

tgaccgtgat gctggtgatg ctgagcaccc cagtggctga ggccagagac tttcccaagg    120

atttcttggt ccagtttaag ggcatgtgct acttcaccaa cgggacagag cgcgtgcggg    180

gtgtggccag atacatctat aaccgcgagg agtacgggcg cttcgacagc gacgttgggg    240

agttccaggc ggtgaccgag ctggggcgga gcatcgagga ctggaacaac tataaggact    300

tcttggagca ggagcgggcc gcggtggaca aggtgtgcag acacaactac gaggcggagc    360

tacgcacgac cttgcagcgg caagtggagc ccacagtgac catctcccca tccaggacag    420

aggccctcaa ccaccacaac ctgctggtct gctcagtgac agatttctat ccagcccaga    480

tcaaagtcca gtggtttcgg aatgaccagg aggagacagc cggtgttgtg tccacctccc    540

tcattaggaa tggtgactgg accttccaga ttctggtgat gctggaaata actccccagc    600

gtggagacat ctacacctgc caagtggagc accccagcct ccagagcccc atcaccgtgg    660

agtggcgacc tcgagggcct ccacctgcag gactcctgca ctgactcctg aggacttttg    720

tctgggattg gtcatcactc ttctgtaatg cccacctgcc cctgcccaga attcctagct    780

gcctgtgtca tcctgtccca ctgaggtcag agtcctacag tggctcatgc agccacaggt    840

caccttctgt gatccccatc ccaaggcact ggcggtgact ctgcttcctg tactgaccca    900

gagcctctgc ctgtgcactg caagctgtgt ctactcaggc cccaaggggc atctctgttt    960

ccattctccc cccacagacc tgtcaagaga agcatgacaa acaaaatcat ttacctaact   1020

ttagtgcttt ttcccataat taaacctgat tctgagttaa aaaaaaaaaa aaaaaaaaaa   1080

aaaaaaaaaa aa                                                       1092


<210>  1695
<211>  231
<212>  PRT
<213>  Homosapiens

<400>  1695

Met Ser Trp Lys Met Ala Leu Gln Ile Pro Gly Gly Phe Trp Ala Ala 
1               5                   10                  15      


Ala Val Thr Val Met Leu Val Met Leu Ser Thr Pro Val Ala Glu Ala 
            20                  25                  30          


Arg Asp Phe Pro Lys Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln 
65                  70                  75                  80  


Ala Val Thr Glu Leu Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys 
                85                  90                  95      


Asp Phe Leu Glu Gln Glu Arg Ala Ala Val Asp Lys Val Cys Arg His 
            100                 105                 110         


Asn Tyr Glu Ala Glu Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro 
        115                 120                 125             


Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn 
    130                 135                 140                 


Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val 
145                 150                 155                 160 


Gln Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr 
                165                 170                 175     


Ser Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu 
            180                 185                 190         


Glu Ile Thr Pro Gln Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His 
        195                 200                 205             


Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Pro Arg Gly Pro 
    210                 215                 220                 


Pro Pro Ala Gly Leu Leu His 
225                 230     


<210>  1696
<211>  1501
<212>  DNA
<213>  Homosapiens

<400>  1696
agcgagtcct tcttttcctg actgcagctc ttttcatttt gccatccttt tccagctcca     60

tgatggttct gcaggtttct gcggcccccc ggacagtggc tctgacggcg ttactgatgg    120

tgctgctcac atctgtggtc cagggcaggg ccactccaga gaattacctt ttccagggac    180

ggcaggaatg ctacgcgttt aatgggacac agcgcttcct ggagagatac atctacaacc    240

gggaggagtt cgcgcgcttc gacagcgacg tgggggagtt ccgggcggtg acggagctgg    300

ggcggcctgc tgcggagtac tggaacagcc agaaggacat cctggaggag aagcgggcag    360

tgccggacag gatgtgcaga cacaactacg agctgggcgg gcccatgacc ctgcagcgcc    420

gagtccagcc tagggtgaat gtttccccct ccaagaaggg gcccttgcag caccacaacc    480

tgcttgtctg ccacgtgacg gatttctacc caggcagcat tcaagtccga tggttcctga    540

atggacagga ggaaacagct ggggtcgtgt ccaccaacct gatccgtaat ggagactgga    600

ccttccagat cctggtgatg ctggaaatga ccccccagca gggagatgtc tacacctgcc    660

aagtggagca caccagcctg gatagtcctg tcaccgtgga gtggaaggca cagtctgatt    720

ctgcccggag taagacattg acgggagctg ggggcttcgt gctggggctc atcatctgtg    780

gagtgggcat cttcatgcac aggaggagca agaaagttca acgaggatct gcataaacag    840

ggttcctgag ctcactgaaa agactattgt gccttaggaa aagcatttgc tgtgtttcgt    900

tagcatctgg ctccaggaca gaccttcaac ttccaaattg gatactgctg ccaagaagtt    960

gctctgaagt cagtttctat cattctgctc tttgattcaa agcactgttt ctctcactgg   1020

gcctccaacc atgttccctt cttcttagca ccacaaataa tcaaaaccca acatgactgt   1080

ttgttttcct ttaaaaatat gcaccaaatc atctctcatc acttttctct gagggtttta   1140

gtagacagta ggagttaata aagaagttca ttttggttta aacataggaa agaagagaac   1200

catgaaaatg gggatatgtt aactattgta taatggggcc tgttacacat gacactcttc   1260

tgaattgact gtatttcagt gagctgcccc caaatcaagt ttagtgccct catccattta   1320

tgtctcagac cactattctt aactattcaa tggtgagcag actgcaaatc tgcctgatag   1380

gacccatatt cccacagcac taattcaaca tataccttac tgagagcatg ttttatcatt   1440

accattaaga agttaaatga acatcagaat ttaaaatcat aaatataatc taatacactt   1500

t                                                                   1501


<210>  1697
<211>  258
<212>  PRT
<213>  Homosapiens

<400>  1697

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  1698
<211>  805
<212>  DNA
<213>  Homosapiens

<400>  1698
atgatgatcc tgcaggtttc agcgggcccc cggacagtgg ctctgacagc attactgatg     60

gtgcggctca tatctgtggt ccagagcagg accactccag agaattccgt ctaccaggaa    120

cggcaggaat gctatgcgtt caatgggact cagcgcgttg tggacgggct catctacaac    180

cgggaggaat acgtgcattt tgacagcgca gtgggggagt tcctagcagt gatggagctg    240

gggcggccca taggcgagta cttcaatagc cagaaggact ttatggaacg gaagcgagcc    300

gaggtggaca aggtgtgcag acacaagtac gagctgatgg agccactcat ccggcagcgc    360

cgagtccagc ctagggtgaa catctcccct ccaagaagga gccccagcag caccacgacc    420

tgcttgtcta ccacgtgaca gatttctacc cagacagcat tcaagtccga tgcttcctga    480

atggacagga ggaaacagct ggggtcgtgt ccaccaacct gatccgtaat ggagactgga    540

ccttccagat cctggagatg ctggaaatga ccccccagca gggaaacatc tacacctgcc    600

aagtggagca ccccagcctg gacagtcctg tcaccgtgga gtggaaggca cagtctgatt    660

ctgtgcagag caagatgctg acaggagcta ggggcttcat gctggggctc atcatctgtg    720

gagtggacat cttcacgcac agaaggagga agaaagttca acaaggacct gcataaacag    780

gcaatattcc tgctttgatt tcctt                                          805


<210>  1699
<211>  6093
<212>  DNA
<213>  Homosapiens

<400>  1699
cacacagaag cggcagccac cgaggaggga gcagtgccgg gagccccgac ggcgccttgc     60

tgcatggagc tgggccgctg acagctgtcg tgcccgcagc ctctgacctc cctgggaccc    120

cggcgtctga ggctcatagt ctgctccctg tcttctgtca gcctcagggc atccagcgtc    180

tcaggccgac ctgtccctgg gacccggcgt ttcgcttctc agccatggag cggtgcagcc    240

gctgccatcg cctcctcctc ctcctacctc tggtgctggg gctgagcgcg gccccaggct    300

gggcaggtgc accccctgtg gatgtgctcc gggccctgag gttcccctcc ctccctgatg    360

gtgtccggag agcgaaaggc atctgtccag ctgatgtggc ctaccgagtg gcacgacctg    420

cccagctcag tgcacccact cgccagcttt tcccaggagg atttcccaaa gatttctctc    480

tgctgactgt tgtccggacc cgccctggtc tccaagctcc cctcctgact ctctacagtg    540

cccagggtgt ccgacagctg ggcctggagc tgggccgacc tgtccgcttc ctgtatgaag    600

accagacagg gcggcctcaa cctccctctc agccagtctt ccgaggcctc agcctagcag    660

atggcaagtg gcaccgtgtg gctgtggctg tgaagggcca gtctgtcacc ctcattgttg    720

actgcaagaa gcgagtcacc cggcctctcc cccgaagtgc tcgtccagta ttggacaccc    780

atggagtgat catctttggt gcccgtattc tggatgaaga agtctttgag ggtgatgtcc    840

aggagctggc cattgtccca ggggtccagg cagcctatga atcatgtgaa cagaaggagc    900

tggaatgcga ggggggccag agggaaagac cccaaaacca acagcctcac agagcccaga    960

gatctccaca gcagcaacca tcaagacttc acaggccaca aaatcaggaa ccccagagcc   1020

aggctgccca tggaccccga gggctgaagg gagagaaagg agagcctgca gtgttggaac   1080

ctggtatgct cgtggagggg ccccctggcc cagaagggcc tgcgggattg attggtcccc   1140

ctggcatcca ggggaaccca ggcccagttg gagaccctgg agagaggggc ccccctggcc   1200

gagcagggct ccctggatca gatggggctc ctggtcctcc tggcacatct ctcatgctcc   1260

cattccggtt tggcagtggt gggggtgaca agggccctgt ggtggcggcc caggaggctc   1320

aggcccaggc gatcctgcag caggcgaggc tggcgctccg tggaccccct ggccccatgg   1380

gatacacagg gcgccctgga cccttgggcc aacctgggag ccctggcctg aaaggagagt   1440

ctggagactt aggacctcag ggccccagag gacctcaggg cctcacaggc tccctgggca   1500

aggctgggcg aaggggccgg gcaggtgctg atggagcccg agggatgcct ggagatcctg   1560

gagtgaaggg tgaccgaggt tttgatggac tcccagggct ccctggagag aagggccata   1620

ggggtgatac tggtgcccag ggccttcctg gtccccctgg tgaggatgga gagaggggag   1680

atgacgggga gattgggcct cgagggctgc ctggagagtc gggacctcga ggtctccttg   1740

gccccaaagg cccacctggt attcctggac cccctggcgt ccgaggcatg gatggtcccc   1800

agggccccaa agggagcttg ggaccccagg gagagccagg acctcctgga caacagggca   1860

cccctgggac ccagggtctt cccgggcccc agggtgccat cggccctcat ggagagaagg   1920

gtcctcaagg gaagccaggg ctccccggca tgcctggctc agacggaccc ccgggtcacc   1980

cagggaagga aggtccccct ggaaccaaag gaaaccaggg tccctctgga cctcagggac   2040

ctctaggata cccaggacct cgaggggtca agggtgtgga cggaattcgg ggtctgaagg   2100

gtcataaggg tgagaagggt gaggatggct ttcctgggtt caaaggtgac ataggcgtga   2160

aaggtgacag gggcgaagtt ggagtccctg gttccagggg agaggatggt cctgaggggc   2220

caaagggacg cactggaccg actggagacc ctgggccccc agggctcatg ggcgagaagg   2280

gcaagctggg tgttcctggt ctgcctggct atcctggacg tcagggaccc aaggggtccc   2340

taggatttcc tggctttcct ggtgccagtg gagagaaggg agcccggggc ctgtcgggga   2400

agtcagggcc tcggggagaa cggggcccca cgggtccacg gggtcagcgg ggaccccgag   2460

gtgccactgg gaagtctgga gctaagggaa catctggtgg tgatggcccc catggccccc   2520

ctggagagag gggcctccct ggacctcagg gtcccaacgg gtttcctgga ccgaaaggac   2580

ccccgggccc ccctgggaag gacgggctgc cgggacaccc aggccaaaga ggagaagtgg   2640

gtttccaagg gaagaccggc ccccctggtc ctccaggagt ggtgggacct cagggagcag   2700

caggagaaac cggccctatg ggggagagag gtcacccagg ccccccgggg ccccctggag   2760

agcagggact acctgggaca gctggaaaag aaggaacaaa gggtgaccct ggtccccctg   2820

gggccccagg gaaggatggt cctgctggtc tgaggggatt cccaggagag agaggcctcc   2880

caggcactgc tggtggacct ggtttgaagg ggaatgaagg tccgtctggc ccccctggcc   2940

ctgcaggctc ccctggggaa cgaggtgcag caggatcagg gggacccatt ggtcgccagg   3000

ggcgcccagg cccgcagggt ccccctggag cagcaggaga gaaaggtgtc ccaggtgaga   3060

agggccccat tggcccgact ggccgagatg gagtgcaggg tcctgtgggg cttcctggtc   3120

ctgctgggcc tccaggtgtg gctggagagg atggagacaa gggtgaggtg ggggaccccg   3180

gacagaaggg caccaaaggg aacaagggtg aacatggccc tcctggaccc cctggaccca   3240

ttggtcctgt ggggcagcct ggagcagcgg gagcagatgg ggagcccgga gctcggggac   3300

cccagggaca ctttggagcc aaaggtgatg aaggaacaag aggattcaat gggcccccag   3360

gacccattgg cctacagggt ttgccaggcc cctctgggga gaagggagaa acaggagatg   3420

tgggtcctat gggaccacct ggccccccag gacctcgagg tccagctgga cccaatggcg   3480

ctgatggccc acaaggtccc ccaggaggtg ttgggaacct gggtccccct ggagagaagg   3540

gggaaccagg agagtcagga tctccaggga tccagggcga gccaggtgtc aagggtccac   3600

gcggggaacg tggagagaaa ggagagtcgg ggcagccagg agagccaggg ccaccaggcg   3660

ctaaaggccc acagggcgat gatggcccca aagggaaccc tggtcctgtt ggttttcctg   3720

gtgaccctgg cccccctgga gaaggtggcc ctcggggcca ggatggtgct aagggtgacc   3780

gaggcgagga tggtgagcca ggacagcctg gatcccctgg tcccaccggg gagaatggac   3840

ccccagggcc acttggaaag cgaggtcctg ctggctcgcc tggttccgag gggcgacaag   3900

gagggaaggg agccaaggga gatcctggcg ctataggtgc cccggggaag acaggcccgg   3960

tgggtcctgc aggcccagca gggaaacctg gccctgatgg tctgaggggg ctcccaggct   4020

cagtgggtca gcaaggccga cctggagcta caggccaggc tgggccccca ggtcctgtgg   4080

gacccccagg gctgcctggt ctccggggcg atgctggagc caagggagag aagggccacc   4140

caggtctcat tggactgatt gggcccccgg gtgagcaggg agagaaggga gatcggggac   4200

ttcctgggcc tcagggctcc cctgggcaga agggtgagat gggtatccca ggagcatccg   4260

gccccattgg tcctggaggt ccccccggcc tccccggacc tgctggcccc aaaggagcca   4320

aaggagccac aggcccaggc ggacccaagg gagagaaggg tgtgcagggc cctccaggac   4380

acccgggtcc cccaggcgag gtgatccagc cactgcccat tcagatgccc aagaagactc   4440

ggcgctcggt ggatggaagc cgtctgatgc aggaagatga ggccataccg accgggggag   4500

cccccggcag tcctgggggg ctggaggaga tctttggctc actcgactcc ctgcgggagg   4560

agatcgagca gatgaggcgg ccaacaggga cccaggacag ccctgctcgc acctgccagg   4620

acctgaagct gtgccaccca gagcttcccg atggagagta ctgggtcgac cccaaccagg   4680

gctgtgctcg ggatgccttc cgagttttct gcaacttcac agcagggggt gagacctgtg   4740

tgacgcctag ggatgacgtc acgcagttct cttacgtgga ctcagagggc tccccagtgg   4800

gtgtggtcca gctcaccttc ctgcggctgc tcagcgtctc agcccaccag gacgtctcct   4860

acccctgctc tggagcagcc cgtgacggtc ccctgagact ccgtggggcc aatgaggatg   4920

agctgagccc ggagactagc ccctatgtca aagaattcag agatggctgc cagacacagc   4980

aaggccggac ggtgctggag gtgcgaacgc ctgtgctgga gcagctgcca gtgctggatg   5040

cctccttctc agacctggga gccccaccga ggcggggagg ggtgctgctg gggcctgtct   5100

gcttcatggg ataggaccgt ctctgtctga tcctgtccat tcggtaccag gcccacctgg   5160

aatcccacaa catcagctct gtgccacctc ccaagagggc tcctcactat ctagggagcc   5220

ctgggccagg gctggagagc cctcagtcgg ggcaggccag gggaggggtg aagtggttgc   5280

ctggacaccc cacgggagga gtggcatctg ggctcttggc cctcccacct ggagcctgtt   5340

acccgttaga gagctgagag cccttattta aaactcacct cccaatcacc ccaaacaaat   5400

ggaagagaag agaaaggaca tggcgtattt tgtatttaaa agtaattgta ttaattattt   5460

aaagtgtgga aagcaaaata acaaaaaaga gaaacgccaa caaaaaatca gcagatgttg   5520

aagacagggg tctcgggggt gggctccggc acccacatct gagtcaggac tttcctcagt   5580

gactgtgtgt aggggggttc agggctgaac ccacctccct cccaccttcc tcccacctca   5640

cctgtcgcac ccactgtgaa agttggaata tgtggtctcc ctggcctcag ggctctgact   5700

ctgccagggt ggggctctct aacccacagg tgttggctgc ctggcccatg tgcccactgt   5760

ctcttccact tggtctgggt ttggcaggca ctgctgctac ttgagggcca ggatgctccc   5820

ccagggaaga aacggaatag tgtggggtgt gtgcagggct gcatccgcag atggctggaa   5880

tattaaaatt cttctatatt ggctggtaaa ttgccatggc cctgagccac tgagtatgtt   5940

cattgccacc cctgtcctcc cctgggcacc cctcactttc cctgatcctg caattaaagg   6000

gttaatgtgt ggcatatgga agggactccc aggaccctgt gcccagcttc catgctgact   6060

gatggttaaa taatgtgatt gtctcctccc agg                                6093


<210>  1700
<211>  1629
<212>  PRT
<213>  Homosapiens

<400>  1700

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Ala Ala His Gly Pro Arg 
            260                 265                 270         


Gly Leu Lys Gly Glu Lys Gly Glu Pro Ala Val Leu Glu Pro Gly Met 
        275                 280                 285             


Leu Val Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Ile Gly 
    290                 295                 300                 


Pro Pro Gly Ile Gln Gly Asn Pro Gly Pro Val Gly Asp Pro Gly Glu 
305                 310                 315                 320 


Arg Gly Pro Pro Gly Arg Ala Gly Leu Pro Gly Ser Asp Gly Ala Pro 
                325                 330                 335     


Gly Pro Pro Gly Thr Ser Leu Met Leu Pro Phe Arg Phe Gly Ser Gly 
            340                 345                 350         


Gly Gly Asp Lys Gly Pro Val Val Ala Ala Gln Glu Ala Gln Ala Gln 
        355                 360                 365             


Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro Pro Gly Pro 
    370                 375                 380                 


Met Gly Tyr Thr Gly Arg Pro Gly Pro Leu Gly Gln Pro Gly Ser Pro 
385                 390                 395                 400 


Gly Leu Lys Gly Glu Ser Gly Asp Leu Gly Pro Gln Gly Pro Arg Gly 
                405                 410                 415     


Pro Gln Gly Leu Thr Gly Ser Leu Gly Lys Ala Gly Arg Arg Gly Arg 
            420                 425                 430         


Ala Gly Ala Asp Gly Ala Arg Gly Met Pro Gly Asp Pro Gly Val Lys 
        435                 440                 445             


Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu Pro Gly Glu Lys Gly 
    450                 455                 460                 


His Arg Gly Asp Thr Gly Ala Gln Gly Leu Pro Gly Pro Pro Gly Glu 
465                 470                 475                 480 


Asp Gly Glu Arg Gly Asp Asp Gly Glu Ile Gly Pro Arg Gly Leu Pro 
                485                 490                 495     


Gly Glu Ser Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly Pro Pro Gly 
            500                 505                 510         


Ile Pro Gly Pro Pro Gly Val Arg Gly Met Asp Gly Pro Gln Gly Pro 
        515                 520                 525             


Lys Gly Ser Leu Gly Pro Gln Gly Glu Pro Gly Pro Pro Gly Gln Gln 
    530                 535                 540                 


Gly Thr Pro Gly Thr Gln Gly Leu Pro Gly Pro Gln Gly Ala Ile Gly 
545                 550                 555                 560 


Pro His Gly Glu Lys Gly Pro Gln Gly Lys Pro Gly Leu Pro Gly Met 
                565                 570                 575     


Pro Gly Ser Asp Gly Pro Pro Gly His Pro Gly Lys Glu Gly Pro Pro 
            580                 585                 590         


Gly Thr Lys Gly Asn Gln Gly Pro Ser Gly Pro Gln Gly Pro Leu Gly 
        595                 600                 605             


Tyr Pro Gly Pro Arg Gly Val Lys Gly Val Asp Gly Ile Arg Gly Leu 
    610                 615                 620                 


Lys Gly His Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro Gly Phe Lys 
625                 630                 635                 640 


Gly Asp Ile Gly Val Lys Gly Asp Arg Gly Glu Val Gly Val Pro Gly 
                645                 650                 655     


Ser Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg Thr Gly Pro 
            660                 665                 670         


Thr Gly Asp Pro Gly Pro Pro Gly Leu Met Gly Glu Lys Gly Lys Leu 
        675                 680                 685             


Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly Pro Lys Gly 
    690                 695                 700                 


Ser Leu Gly Phe Pro Gly Phe Pro Gly Ala Ser Gly Glu Lys Gly Ala 
705                 710                 715                 720 


Arg Gly Leu Ser Gly Lys Ser Gly Pro Arg Gly Glu Arg Gly Pro Thr 
                725                 730                 735     


Gly Pro Arg Gly Gln Arg Gly Pro Arg Gly Ala Thr Gly Lys Ser Gly 
            740                 745                 750         


Ala Lys Gly Thr Ser Gly Gly Asp Gly Pro His Gly Pro Pro Gly Glu 
        755                 760                 765             


Arg Gly Leu Pro Gly Pro Gln Gly Pro Asn Gly Phe Pro Gly Pro Lys 
    770                 775                 780                 


Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly His Pro Gly 
785                 790                 795                 800 


Gln Arg Gly Glu Val Gly Phe Gln Gly Lys Thr Gly Pro Pro Gly Pro 
                805                 810                 815     


Pro Gly Val Val Gly Pro Gln Gly Ala Ala Gly Glu Thr Gly Pro Met 
            820                 825                 830         


Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro Pro Gly Glu Gln Gly 
        835                 840                 845             


Leu Pro Gly Thr Ala Gly Lys Glu Gly Thr Lys Gly Asp Pro Gly Pro 
    850                 855                 860                 


Pro Gly Ala Pro Gly Lys Asp Gly Pro Ala Gly Leu Arg Gly Phe Pro 
865                 870                 875                 880 


Gly Glu Arg Gly Leu Pro Gly Thr Ala Gly Gly Pro Gly Leu Lys Gly 
                885                 890                 895     


Asn Glu Gly Pro Ser Gly Pro Pro Gly Pro Ala Gly Ser Pro Gly Glu 
            900                 905                 910         


Arg Gly Ala Ala Gly Ser Gly Gly Pro Ile Gly Arg Gln Gly Arg Pro 
        915                 920                 925             


Gly Pro Gln Gly Pro Pro Gly Ala Ala Gly Glu Lys Gly Val Pro Gly 
    930                 935                 940                 


Glu Lys Gly Pro Ile Gly Pro Thr Gly Arg Asp Gly Val Gln Gly Pro 
945                 950                 955                 960 


Val Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Val Ala Gly Glu Asp 
                965                 970                 975     


Gly Asp Lys Gly Glu Val Gly Asp Pro Gly Gln Lys Gly Thr Lys Gly 
            980                 985                 990         


Asn Lys Gly Glu His Gly Pro Pro  Gly Pro Pro Gly Pro  Ile Gly Pro 
        995                 1000                 1005             


Val Gly  Gln Pro Gly Ala Ala  Gly Ala Asp Gly Glu  Pro Gly Ala 
    1010                 1015                 1020             


Arg Gly  Pro Gln Gly His Phe  Gly Ala Lys Gly Asp  Glu Gly Thr 
    1025                 1030                 1035             


Arg Gly  Phe Asn Gly Pro Pro  Gly Pro Ile Gly Leu  Gln Gly Leu 
    1040                 1045                 1050             


Pro Gly  Pro Ser Gly Glu Lys  Gly Glu Thr Gly Asp  Val Gly Pro 
    1055                 1060                 1065             


Met Gly  Pro Pro Gly Pro Pro  Gly Pro Arg Gly Pro  Ala Gly Pro 
    1070                 1075                 1080             


Asn Gly  Ala Asp Gly Pro Gln  Gly Pro Pro Gly Gly  Val Gly Asn 
    1085                 1090                 1095             


Leu Gly  Pro Pro Gly Glu Lys  Gly Glu Pro Gly Glu  Ser Gly Ser 
    1100                 1105                 1110             


Pro Gly  Ile Gln Gly Glu Pro  Gly Val Lys Gly Pro  Arg Gly Glu 
    1115                 1120                 1125             


Arg Gly  Glu Lys Gly Glu Ser  Gly Gln Pro Gly Glu  Pro Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ala Lys Gly Pro Gln  Gly Asp Asp Gly Pro  Lys Gly Asn 
    1145                 1150                 1155             


Pro Gly  Pro Val Gly Phe Pro  Gly Asp Pro Gly Pro  Pro Gly Glu 
    1160                 1165                 1170             


Gly Gly  Pro Arg Gly Gln Asp  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1175                 1180                 1185             


Asp Gly  Glu Pro Gly Gln Pro  Gly Ser Pro Gly Pro  Thr Gly Glu 
    1190                 1195                 1200             


Asn Gly  Pro Pro Gly Pro Leu  Gly Lys Arg Gly Pro  Ala Gly Ser 
    1205                 1210                 1215             


Pro Gly  Ser Glu Gly Arg Gln  Gly Gly Lys Gly Ala  Lys Gly Asp 
    1220                 1225                 1230             


Pro Gly  Ala Ile Gly Ala Pro  Gly Lys Thr Gly Pro  Val Gly Pro 
    1235                 1240                 1245             


Ala Gly  Pro Ala Gly Lys Pro  Gly Pro Asp Gly Leu  Arg Gly Leu 
    1250                 1255                 1260             


Pro Gly  Ser Val Gly Gln Gln  Gly Arg Pro Gly Ala  Thr Gly Gln 
    1265                 1270                 1275             


Ala Gly  Pro Pro Gly Pro Val  Gly Pro Pro Gly Leu  Pro Gly Leu 
    1280                 1285                 1290             


Arg Gly  Asp Ala Gly Ala Lys  Gly Glu Lys Gly His  Pro Gly Leu 
    1295                 1300                 1305             


Ile Gly  Leu Ile Gly Pro Pro  Gly Glu Gln Gly Glu  Lys Gly Asp 
    1310                 1315                 1320             


Arg Gly  Leu Pro Gly Pro Gln  Gly Ser Pro Gly Gln  Lys Gly Glu 
    1325                 1330                 1335             


Met Gly  Ile Pro Gly Ala Ser  Gly Pro Ile Gly Pro  Gly Gly Pro 
    1340                 1345                 1350             


Pro Gly  Leu Pro Gly Pro Ala  Gly Pro Lys Gly Ala  Lys Gly Ala 
    1355                 1360                 1365             


Thr Gly  Pro Gly Gly Pro Lys  Gly Glu Lys Gly Val  Gln Gly Pro 
    1370                 1375                 1380             


Pro Gly  His Pro Gly Pro Pro  Gly Glu Val Ile Gln  Pro Leu Pro 
    1385                 1390                 1395             


Ile Gln  Met Pro Lys Lys Thr  Arg Arg Ser Val Asp  Gly Ser Arg 
    1400                 1405                 1410             


Leu Met  Gln Glu Asp Glu Ala  Ile Pro Thr Gly Gly  Ala Pro Gly 
    1415                 1420                 1425             


Ser Pro  Gly Gly Leu Glu Glu  Ile Phe Gly Ser Leu  Asp Ser Leu 
    1430                 1435                 1440             


Arg Glu  Glu Ile Glu Gln Met  Arg Arg Pro Thr Gly  Thr Gln Asp 
    1445                 1450                 1455             


Ser Pro  Ala Arg Thr Cys Gln  Asp Leu Lys Leu Cys  His Pro Glu 
    1460                 1465                 1470             


Leu Pro  Asp Gly Glu Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ala 
    1475                 1480                 1485             


Arg Asp  Ala Phe Arg Val Phe  Cys Asn Phe Thr Ala  Gly Gly Glu 
    1490                 1495                 1500             


Thr Cys  Val Thr Pro Arg Asp  Asp Val Thr Gln Phe  Ser Tyr Val 
    1505                 1510                 1515             


Asp Ser  Glu Gly Ser Pro Val  Gly Val Val Gln Leu  Thr Phe Leu 
    1520                 1525                 1530             


Arg Leu  Leu Ser Val Ser Ala  His Gln Asp Val Ser  Tyr Pro Cys 
    1535                 1540                 1545             


Ser Gly  Ala Ala Arg Asp Gly  Pro Leu Arg Leu Arg  Gly Ala Asn 
    1550                 1555                 1560             


Glu Asp  Glu Leu Ser Pro Glu  Thr Ser Pro Tyr Val  Lys Glu Phe 
    1565                 1570                 1575             


Arg Asp  Gly Cys Gln Thr Gln  Gln Gly Arg Thr Val  Leu Glu Val 
    1580                 1585                 1590             


Arg Thr  Pro Val Leu Glu Gln  Leu Pro Val Leu Asp  Ala Ser Phe 
    1595                 1600                 1605             


Ser Asp  Leu Gly Ala Pro Pro  Arg Arg Gly Gly Val  Leu Leu Gly 
    1610                 1615                 1620             


Pro Val  Cys Phe Met Gly 
    1625                 


<210>  1701
<211>  6414
<212>  DNA
<213>  Homosapiens

<400>  1701
cacacagaag cggcagccac cgaggaggga gcagtgccgg gagccccgac ggcgccttgc     60

tgcatggagc tgggccgctg acagctgtcg tgcccgcagc ctctgacctc cctgggaccc    120

cggcgtctga ggctcatagt ctgctccctg tcttctgtca gcctcagggc atccagcgtc    180

tcaggccgac ctgtccctgg gacccggcgt ttcgcttctc agccatggag cggtgcagcc    240

gctgccatcg cctcctcctc ctcctacctc tggtgctggg gctgagcgcg gccccaggct    300

gggcaggtgc accccctgtg gatgtgctcc gggccctgag gttcccctcc ctccctgatg    360

gtgtccggag agcgaaaggc atctgtccag ctgatgtggc ctaccgagtg gcacgacctg    420

cccagctcag tgcacccact cgccagcttt tcccaggagg atttcccaaa gatttctctc    480

tgctgactgt tgtccggacc cgccctggtc tccaagctcc cctcctgact ctctacagtg    540

cccagggtgt ccgacagctg ggcctggagc tgggccgacc tgtccgcttc ctgtatgaag    600

accagacagg gcggcctcaa cctccctctc agccagtctt ccgaggcctc agcctagcag    660

atggcaagtg gcaccgtgtg gctgtggctg tgaagggcca gtctgtcacc ctcattgttg    720

actgcaagaa gcgagtcacc cggcctctcc cccgaagtgc tcgtccagta ttggacaccc    780

atggagtgat catctttggt gcccgtattc tggatgaaga agtctttgag ggtgatgtcc    840

aggagctggc cattgtccca ggggtccagg cagcctatga atcatgtgaa cagaaggagc    900

tggaatgcga ggggggccag agggaaagac cccaaaacca acagcctcac agagcccaga    960

gatctccaca gcagcaacca tcaagacttc acaggccaca aaatcaggaa ccccagagcc   1020

agcccactga gtctctctac tatgactacg agccccccta ttatgatgtg atgactacgg   1080

ggacaacccc tgattatcag gaccccaccc caggtgaaga ggaagaaatc ctggagtcga   1140

gcctcttgcc accccttgag gaggagcaga cagatctcca ggtccccccc acagccgaca   1200

ggttccaggc agaggaatat ggggagggtg gcacagaccc ccctgaaggg ccctacgatt   1260

acacctatgg ctatggggat gattatcgtg aggagacaga gcttggccct gccctctctg   1320

cggagacagc ccactcagga gccgctgccc atggaccccg agggctgaag ggagagaaag   1380

gagagcctgc agtgttggaa cctggtatgc tcgtggaggg gccccctggc ccagaagggc   1440

ctgcgggatt gattggtccc cctggcatcc aggggaaccc aggcccagtt ggagaccctg   1500

gagagagggg cccccctggc cgagcagggc tccctggatc agatggggct cctggtcctc   1560

ctggcacatc tctcatgctc ccattccggt ttggcagtgg tgggggtgac aagggccctg   1620

tggtggcggc ccaggaggct caggcccagg cgatcctgca gcaggcgagg ctggcgctcc   1680

gtggaccccc tggccccatg ggatacacag ggcgccctgg acccttgggc caacctggga   1740

gccctggcct gaaaggagag tctggagact taggacctca gggccccaga ggacctcagg   1800

gcctcacagg ctccctgggc aaggctgggc gaaggggccg ggcaggtgct gatggagccc   1860

gagggatgcc tggagatcct ggagtgaagg gtgaccgagg ttttgatgga ctcccagggc   1920

tccctggaga gaagggccat aggggtgata ctggtgccca gggccttcct ggtccccctg   1980

gtgaggatgg agagagggga gatgacgggg agattgggcc tcgagggctg cctggagagt   2040

cgggacctcg aggtctcctt ggccccaaag gcccacctgg tattcctgga ccccctggcg   2100

tccgaggcat ggatggtccc cagggcccca aagggagctt gggaccccag ggagagccag   2160

gacctcctgg acaacagggc acccctggga cccagggtct tcccgggccc cagggtgcca   2220

tcggccctca tggagagaag ggtcctcaag ggaagccagg gctccccggc atgcctggct   2280

cagacggacc cccgggtcac ccagggaagg aaggtccccc tggaaccaaa ggaaaccagg   2340

gtccctctgg acctcaggga cctctaggat acccaggacc tcgaggggtc aagggtgtgg   2400

acggaattcg gggtctgaag ggtcataagg gtgagaaggg tgaggatggc tttcctgggt   2460

tcaaaggtga cataggcgtg aaaggtgaca ggggcgaagt tggagtccct ggttccaggg   2520

gagaggatgg tcctgagggg ccaaagggac gcactggacc gactggagac cctgggcccc   2580

cagggctcat gggcgagaag ggcaagctgg gtgttcctgg tctgcctggc tatcctggac   2640

gtcagggacc caaggggtcc ctaggatttc ctggctttcc tggtgccagt ggagagaagg   2700

gagcccgggg cctgtcgggg aagtcagggc ctcggggaga acggggcccc acgggtccac   2760

ggggtcagcg gggaccccga ggtgccactg ggaagtctgg agctaaggga acatctggtg   2820

gtgatggccc ccatggcccc cctggagaga ggggcctccc tggacctcag ggtcccaacg   2880

ggtttcctgg accgaaagga cccccgggcc cccctgggaa ggacgggctg ccgggacacc   2940

caggccaaag aggagaagtg ggtttccaag ggaagaccgg cccccctggt cctccaggag   3000

tggtgggacc tcagggagca gcaggagaaa ccggccctat gggggagaga ggtcacccag   3060

gccccccggg gccccctgga gagcagggac tacctgggac agctggaaaa gaaggaacaa   3120

agggtgaccc tggtccccct ggggccccag ggaaggatgg tcctgctggt ctgaggggat   3180

tcccaggaga gagaggcctc ccaggcactg ctggtggacc tggtttgaag gggaatgaag   3240

gtccgtctgg cccccctggc cctgcaggct cccctgggga acgaggtgca gcaggatcag   3300

ggggacccat tggtcgccag gggcgcccag gcccgcaggg tccccctgga gcagcaggag   3360

agaaaggtgt cccaggtgag aagggcccca ttggcccgac tggccgagat ggagtgcagg   3420

gtcctgtggg gcttcctggt cctgctgggc ctccaggtgt ggctggagag gatggagaca   3480

agggtgaggt gggggacccc ggacagaagg gcaccaaagg gaacaagggt gaacatggcc   3540

ctcctggacc ccctggaccc attggtcctg tggggcagcc tggagcagcg ggagcagatg   3600

gggagcccgg agctcgggga ccccagggac actttggagc caaaggtgat gaaggaacaa   3660

gaggattcaa tgggccccca ggacccattg gcctacaggg tttgccaggc ccctctgggg   3720

agaagggaga aacaggagat gtgggtccta tgggaccacc tggcccccca ggacctcgag   3780

gtccagctgg acccaatggc gctgatggcc cacaaggtcc cccaggaggt gttgggaacc   3840

tgggtccccc tggagagaag ggggaaccag gagagtcagg atctccaggg atccagggcg   3900

agccaggtgt caagggtcca cgcggggaac gtggagagaa aggagagtcg gggcagccag   3960

gagagccagg gccaccaggc gctaaaggcc cacagggcga tgatggcccc aaagggaacc   4020

ctggtcctgt tggttttcct ggtgaccctg gcccccctgg agaaggtggc cctcggggcc   4080

aggatggtgc taagggtgac cgaggcgagg atggtgagcc aggacagcct ggatcccctg   4140

gtcccaccgg ggagaatgga cccccagggc cacttggaaa gcgaggtcct gctggctcgc   4200

ctggttccga ggggcgacaa ggagggaagg gagccaaggg agatcctggc gctataggtg   4260

ccccggggaa gacaggcccg gtgggtcctg caggcccagc agggaaacct ggccctgatg   4320

gtctgagggg gctcccaggc tcagtgggtc agcaaggccg acctggagct acaggccagg   4380

ctgggccccc aggtcctgtg ggacccccag ggctgcctgg tctccggggc gatgctggag   4440

ccaagggaga gaagggccac ccaggtctca ttggactgat tgggcccccg ggtgagcagg   4500

gagagaaggg agatcgggga cttcctgggc ctcagggctc ccctgggcag aagggtgaga   4560

tgggtatccc aggagcatcc ggccccattg gtcctggagg tccccccggc ctccccggac   4620

ctgctggccc caaaggagcc aaaggagcca caggcccagg cggacccaag ggagagaagg   4680

gtgtgcaggg ccctccagga cacccgggtc ccccaggcga ggtgatccag ccactgccca   4740

ttcagatgcc caagaagact cggcgctcgg tggatggaag ccgtctgatg caggaagatg   4800

aggccatacc gaccggggga gcccccggca gtcctggggg gctggaggag atctttggct   4860

cactcgactc cctgcgggag gagatcgagc agatgaggcg gccaacaggg acccaggaca   4920

gccctgctcg cacctgccag gacctgaagc tgtgccaccc agagcttccc gatggagagt   4980

actgggtcga ccccaaccag ggctgtgctc gggatgcctt ccgagttttc tgcaacttca   5040

cagcaggggg tgagacctgt gtgacgccta gggatgacgt cacgcagttc tcttacgtgg   5100

actcagaggg ctccccagtg ggtgtggtcc agctcacctt cctgcggctg ctcagcgtct   5160

cagcccacca ggacgtctcc tacccctgct ctggagcagc ccgtgacggt cccctgagac   5220

tccgtggggc caatgaggat gagctgagcc cggagactag cccctatgtc aaagaattca   5280

gagatggctg ccagacacag caaggccgga cggtgctgga ggtgcgaacg cctgtgctgg   5340

agcagctgcc agtgctggat gcctccttct cagacctggg agccccaccg aggcggggag   5400

gggtgctgct ggggcctgtc tgcttcatgg gataggaccg tctctgtctg atcctgtcca   5460

ttcggtacca ggcccacctg gaatcccaca acatcagctc tgtgccacct cccaagaggg   5520

ctcctcacta tctagggagc cctgggccag ggctggagag ccctcagtcg gggcaggcca   5580

ggggaggggt gaagtggttg cctggacacc ccacgggagg agtggcatct gggctcttgg   5640

ccctcccacc tggagcctgt tacccgttag agagctgaga gcccttattt aaaactcacc   5700

tcccaatcac cccaaacaaa tggaagagaa gagaaaggac atggcgtatt ttgtatttaa   5760

aagtaattgt attaattatt taaagtgtgg aaagcaaaat aacaaaaaag agaaacgcca   5820

acaaaaaatc agcagatgtt gaagacaggg gtctcggggg tgggctccgg cacccacatc   5880

tgagtcagga ctttcctcag tgactgtgtg taggggggtt cagggctgaa cccacctccc   5940

tcccaccttc ctcccacctc acctgtcgca cccactgtga aagttggaat atgtggtctc   6000

cctggcctca gggctctgac tctgccaggg tggggctctc taacccacag gtgttggctg   6060

cctggcccat gtgcccactg tctcttccac ttggtctggg tttggcaggc actgctgcta   6120

cttgagggcc aggatgctcc cccagggaag aaacggaata gtgtggggtg tgtgcagggc   6180

tgcatccgca gatggctgga atattaaaat tcttctatat tggctggtaa attgccatgg   6240

ccctgagcca ctgagtatgt tcattgccac ccctgtcctc ccctgggcac ccctcacttt   6300

ccctgatcct gcaattaaag ggttaatgtg tggcatatgg aagggactcc caggaccctg   6360

tgcccagctt ccatgctgac tgatggttaa ataatgtgat tgtctcctcc cagg         6414


<210>  1702
<211>  1736
<212>  PRT
<213>  Homosapiens

<400>  1702

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Pro Thr Glu Ser Leu Tyr 
            260                 265                 270         


Tyr Asp Tyr Glu Pro Pro Tyr Tyr Asp Val Met Thr Thr Gly Thr Thr 
        275                 280                 285             


Pro Asp Tyr Gln Asp Pro Thr Pro Gly Glu Glu Glu Glu Ile Leu Glu 
    290                 295                 300                 


Ser Ser Leu Leu Pro Pro Leu Glu Glu Glu Gln Thr Asp Leu Gln Val 
305                 310                 315                 320 


Pro Pro Thr Ala Asp Arg Phe Gln Ala Glu Glu Tyr Gly Glu Gly Gly 
                325                 330                 335     


Thr Asp Pro Pro Glu Gly Pro Tyr Asp Tyr Thr Tyr Gly Tyr Gly Asp 
            340                 345                 350         


Asp Tyr Arg Glu Glu Thr Glu Leu Gly Pro Ala Leu Ser Ala Glu Thr 
        355                 360                 365             


Ala His Ser Gly Ala Ala Ala His Gly Pro Arg Gly Leu Lys Gly Glu 
    370                 375                 380                 


Lys Gly Glu Pro Ala Val Leu Glu Pro Gly Met Leu Val Glu Gly Pro 
385                 390                 395                 400 


Pro Gly Pro Glu Gly Pro Ala Gly Leu Ile Gly Pro Pro Gly Ile Gln 
                405                 410                 415     


Gly Asn Pro Gly Pro Val Gly Asp Pro Gly Glu Arg Gly Pro Pro Gly 
            420                 425                 430         


Arg Ala Gly Leu Pro Gly Ser Asp Gly Ala Pro Gly Pro Pro Gly Thr 
        435                 440                 445             


Ser Leu Met Leu Pro Phe Arg Phe Gly Ser Gly Gly Gly Asp Lys Gly 
    450                 455                 460                 


Pro Val Val Ala Ala Gln Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln 
465                 470                 475                 480 


Ala Arg Leu Ala Leu Arg Gly Pro Pro Gly Pro Met Gly Tyr Thr Gly 
                485                 490                 495     


Arg Pro Gly Pro Leu Gly Gln Pro Gly Ser Pro Gly Leu Lys Gly Glu 
            500                 505                 510         


Ser Gly Asp Leu Gly Pro Gln Gly Pro Arg Gly Pro Gln Gly Leu Thr 
        515                 520                 525             


Gly Ser Leu Gly Lys Ala Gly Arg Arg Gly Arg Ala Gly Ala Asp Gly 
    530                 535                 540                 


Ala Arg Gly Met Pro Gly Asp Pro Gly Val Lys Gly Asp Arg Gly Phe 
545                 550                 555                 560 


Asp Gly Leu Pro Gly Leu Pro Gly Glu Lys Gly His Arg Gly Asp Thr 
                565                 570                 575     


Gly Ala Gln Gly Leu Pro Gly Pro Pro Gly Glu Asp Gly Glu Arg Gly 
            580                 585                 590         


Asp Asp Gly Glu Ile Gly Pro Arg Gly Leu Pro Gly Glu Ser Gly Pro 
        595                 600                 605             


Arg Gly Leu Leu Gly Pro Lys Gly Pro Pro Gly Ile Pro Gly Pro Pro 
    610                 615                 620                 


Gly Val Arg Gly Met Asp Gly Pro Gln Gly Pro Lys Gly Ser Leu Gly 
625                 630                 635                 640 


Pro Gln Gly Glu Pro Gly Pro Pro Gly Gln Gln Gly Thr Pro Gly Thr 
                645                 650                 655     


Gln Gly Leu Pro Gly Pro Gln Gly Ala Ile Gly Pro His Gly Glu Lys 
            660                 665                 670         


Gly Pro Gln Gly Lys Pro Gly Leu Pro Gly Met Pro Gly Ser Asp Gly 
        675                 680                 685             


Pro Pro Gly His Pro Gly Lys Glu Gly Pro Pro Gly Thr Lys Gly Asn 
    690                 695                 700                 


Gln Gly Pro Ser Gly Pro Gln Gly Pro Leu Gly Tyr Pro Gly Pro Arg 
705                 710                 715                 720 


Gly Val Lys Gly Val Asp Gly Ile Arg Gly Leu Lys Gly His Lys Gly 
                725                 730                 735     


Glu Lys Gly Glu Asp Gly Phe Pro Gly Phe Lys Gly Asp Ile Gly Val 
            740                 745                 750         


Lys Gly Asp Arg Gly Glu Val Gly Val Pro Gly Ser Arg Gly Glu Asp 
        755                 760                 765             


Gly Pro Glu Gly Pro Lys Gly Arg Thr Gly Pro Thr Gly Asp Pro Gly 
    770                 775                 780                 


Pro Pro Gly Leu Met Gly Glu Lys Gly Lys Leu Gly Val Pro Gly Leu 
785                 790                 795                 800 


Pro Gly Tyr Pro Gly Arg Gln Gly Pro Lys Gly Ser Leu Gly Phe Pro 
                805                 810                 815     


Gly Phe Pro Gly Ala Ser Gly Glu Lys Gly Ala Arg Gly Leu Ser Gly 
            820                 825                 830         


Lys Ser Gly Pro Arg Gly Glu Arg Gly Pro Thr Gly Pro Arg Gly Gln 
        835                 840                 845             


Arg Gly Pro Arg Gly Ala Thr Gly Lys Ser Gly Ala Lys Gly Thr Ser 
    850                 855                 860                 


Gly Gly Asp Gly Pro His Gly Pro Pro Gly Glu Arg Gly Leu Pro Gly 
865                 870                 875                 880 


Pro Gln Gly Pro Asn Gly Phe Pro Gly Pro Lys Gly Pro Pro Gly Pro 
                885                 890                 895     


Pro Gly Lys Asp Gly Leu Pro Gly His Pro Gly Gln Arg Gly Glu Val 
            900                 905                 910         


Gly Phe Gln Gly Lys Thr Gly Pro Pro Gly Pro Pro Gly Val Val Gly 
        915                 920                 925             


Pro Gln Gly Ala Ala Gly Glu Thr Gly Pro Met Gly Glu Arg Gly His 
    930                 935                 940                 


Pro Gly Pro Pro Gly Pro Pro Gly Glu Gln Gly Leu Pro Gly Thr Ala 
945                 950                 955                 960 


Gly Lys Glu Gly Thr Lys Gly Asp Pro Gly Pro Pro Gly Ala Pro Gly 
                965                 970                 975     


Lys Asp Gly Pro Ala Gly Leu Arg Gly Phe Pro Gly Glu Arg Gly Leu 
            980                 985                 990         


Pro Gly Thr Ala Gly Gly Pro Gly  Leu Lys Gly Asn Glu  Gly Pro Ser 
        995                 1000                 1005             


Gly Pro  Pro Gly Pro Ala Gly  Ser Pro Gly Glu Arg  Gly Ala Ala 
    1010                 1015                 1020             


Gly Ser  Gly Gly Pro Ile Gly  Arg Gln Gly Arg Pro  Gly Pro Gln 
    1025                 1030                 1035             


Gly Pro  Pro Gly Ala Ala Gly  Glu Lys Gly Val Pro  Gly Glu Lys 
    1040                 1045                 1050             


Gly Pro  Ile Gly Pro Thr Gly  Arg Asp Gly Val Gln  Gly Pro Val 
    1055                 1060                 1065             


Gly Leu  Pro Gly Pro Ala Gly  Pro Pro Gly Val Ala  Gly Glu Asp 
    1070                 1075                 1080             


Gly Asp  Lys Gly Glu Val Gly  Asp Pro Gly Gln Lys  Gly Thr Lys 
    1085                 1090                 1095             


Gly Asn  Lys Gly Glu His Gly  Pro Pro Gly Pro Pro  Gly Pro Ile 
    1100                 1105                 1110             


Gly Pro  Val Gly Gln Pro Gly  Ala Ala Gly Ala Asp  Gly Glu Pro 
    1115                 1120                 1125             


Gly Ala  Arg Gly Pro Gln Gly  His Phe Gly Ala Lys  Gly Asp Glu 
    1130                 1135                 1140             


Gly Thr  Arg Gly Phe Asn Gly  Pro Pro Gly Pro Ile  Gly Leu Gln 
    1145                 1150                 1155             


Gly Leu  Pro Gly Pro Ser Gly  Glu Lys Gly Glu Thr  Gly Asp Val 
    1160                 1165                 1170             


Gly Pro  Met Gly Pro Pro Gly  Pro Pro Gly Pro Arg  Gly Pro Ala 
    1175                 1180                 1185             


Gly Pro  Asn Gly Ala Asp Gly  Pro Gln Gly Pro Pro  Gly Gly Val 
    1190                 1195                 1200             


Gly Asn  Leu Gly Pro Pro Gly  Glu Lys Gly Glu Pro  Gly Glu Ser 
    1205                 1210                 1215             


Gly Ser  Pro Gly Ile Gln Gly  Glu Pro Gly Val Lys  Gly Pro Arg 
    1220                 1225                 1230             


Gly Glu  Arg Gly Glu Lys Gly  Glu Ser Gly Gln Pro  Gly Glu Pro 
    1235                 1240                 1245             


Gly Pro  Pro Gly Ala Lys Gly  Pro Gln Gly Asp Asp  Gly Pro Lys 
    1250                 1255                 1260             


Gly Asn  Pro Gly Pro Val Gly  Phe Pro Gly Asp Pro  Gly Pro Pro 
    1265                 1270                 1275             


Gly Glu  Gly Gly Pro Arg Gly  Gln Asp Gly Ala Lys  Gly Asp Arg 
    1280                 1285                 1290             


Gly Glu  Asp Gly Glu Pro Gly  Gln Pro Gly Ser Pro  Gly Pro Thr 
    1295                 1300                 1305             


Gly Glu  Asn Gly Pro Pro Gly  Pro Leu Gly Lys Arg  Gly Pro Ala 
    1310                 1315                 1320             


Gly Ser  Pro Gly Ser Glu Gly  Arg Gln Gly Gly Lys  Gly Ala Lys 
    1325                 1330                 1335             


Gly Asp  Pro Gly Ala Ile Gly  Ala Pro Gly Lys Thr  Gly Pro Val 
    1340                 1345                 1350             


Gly Pro  Ala Gly Pro Ala Gly  Lys Pro Gly Pro Asp  Gly Leu Arg 
    1355                 1360                 1365             


Gly Leu  Pro Gly Ser Val Gly  Gln Gln Gly Arg Pro  Gly Ala Thr 
    1370                 1375                 1380             


Gly Gln  Ala Gly Pro Pro Gly  Pro Val Gly Pro Pro  Gly Leu Pro 
    1385                 1390                 1395             


Gly Leu  Arg Gly Asp Ala Gly  Ala Lys Gly Glu Lys  Gly His Pro 
    1400                 1405                 1410             


Gly Leu  Ile Gly Leu Ile Gly  Pro Pro Gly Glu Gln  Gly Glu Lys 
    1415                 1420                 1425             


Gly Asp  Arg Gly Leu Pro Gly  Pro Gln Gly Ser Pro  Gly Gln Lys 
    1430                 1435                 1440             


Gly Glu  Met Gly Ile Pro Gly  Ala Ser Gly Pro Ile  Gly Pro Gly 
    1445                 1450                 1455             


Gly Pro  Pro Gly Leu Pro Gly  Pro Ala Gly Pro Lys  Gly Ala Lys 
    1460                 1465                 1470             


Gly Ala  Thr Gly Pro Gly Gly  Pro Lys Gly Glu Lys  Gly Val Gln 
    1475                 1480                 1485             


Gly Pro  Pro Gly His Pro Gly  Pro Pro Gly Glu Val  Ile Gln Pro 
    1490                 1495                 1500             


Leu Pro  Ile Gln Met Pro Lys  Lys Thr Arg Arg Ser  Val Asp Gly 
    1505                 1510                 1515             


Ser Arg  Leu Met Gln Glu Asp  Glu Ala Ile Pro Thr  Gly Gly Ala 
    1520                 1525                 1530             


Pro Gly  Ser Pro Gly Gly Leu  Glu Glu Ile Phe Gly  Ser Leu Asp 
    1535                 1540                 1545             


Ser Leu  Arg Glu Glu Ile Glu  Gln Met Arg Arg Pro  Thr Gly Thr 
    1550                 1555                 1560             


Gln Asp  Ser Pro Ala Arg Thr  Cys Gln Asp Leu Lys  Leu Cys His 
    1565                 1570                 1575             


Pro Glu  Leu Pro Asp Gly Glu  Tyr Trp Val Asp Pro  Asn Gln Gly 
    1580                 1585                 1590             


Cys Ala  Arg Asp Ala Phe Arg  Val Phe Cys Asn Phe  Thr Ala Gly 
    1595                 1600                 1605             


Gly Glu  Thr Cys Val Thr Pro  Arg Asp Asp Val Thr  Gln Phe Ser 
    1610                 1615                 1620             


Tyr Val  Asp Ser Glu Gly Ser  Pro Val Gly Val Val  Gln Leu Thr 
    1625                 1630                 1635             


Phe Leu  Arg Leu Leu Ser Val  Ser Ala His Gln Asp  Val Ser Tyr 
    1640                 1645                 1650             


Pro Cys  Ser Gly Ala Ala Arg  Asp Gly Pro Leu Arg  Leu Arg Gly 
    1655                 1660                 1665             


Ala Asn  Glu Asp Glu Leu Ser  Pro Glu Thr Ser Pro  Tyr Val Lys 
    1670                 1675                 1680             


Glu Phe  Arg Asp Gly Cys Gln  Thr Gln Gln Gly Arg  Thr Val Leu 
    1685                 1690                 1695             


Glu Val  Arg Thr Pro Val Leu  Glu Gln Leu Pro Val  Leu Asp Ala 
    1700                 1705                 1710             


Ser Phe  Ser Asp Leu Gly Ala  Pro Pro Arg Arg Gly  Gly Val Leu 
    1715                 1720                 1725             


Leu Gly  Pro Val Cys Phe Met  Gly 
    1730                 1735     


<210>  1703
<211>  6156
<212>  DNA
<213>  Homosapiens

<400>  1703
cacacagaag cggcagccac cgaggaggga gcagtgccgg gagccccgac ggcgccttgc     60

tgcatggagc tgggccgctg acagctgtcg tgcccgcagc ctctgacctc cctgggaccc    120

cggcgtctga ggctcatagt ctgctccctg tcttctgtca gcctcagggc atccagcgtc    180

tcaggccgac ctgtccctgg gacccggcgt ttcgcttctc agccatggag cggtgcagcc    240

gctgccatcg cctcctcctc ctcctacctc tggtgctggg gctgagcgcg gccccaggct    300

gggcaggtgc accccctgtg gatgtgctcc gggccctgag gttcccctcc ctccctgatg    360

gtgtccggag agcgaaaggc atctgtccag ctgatgtggc ctaccgagtg gcacgacctg    420

cccagctcag tgcacccact cgccagcttt tcccaggagg atttcccaaa gatttctctc    480

tgctgactgt tgtccggacc cgccctggtc tccaagctcc cctcctgact ctctacagtg    540

cccagggtgt ccgacagctg ggcctggagc tgggccgacc tgtccgcttc ctgtatgaag    600

accagacagg gcggcctcaa cctccctctc agccagtctt ccgaggcctc agcctagcag    660

atggcaagtg gcaccgtgtg gctgtggctg tgaagggcca gtctgtcacc ctcattgttg    720

actgcaagaa gcgagtcacc cggcctctcc cccgaagtgc tcgtccagta ttggacaccc    780

atggagtgat catctttggt gcccgtattc tggatgaaga agtctttgag ggtgatgtcc    840

aggagctggc cattgtccca ggggtccagg cagcctatga atcatgtgaa cagaaggagc    900

tggaatgcga ggggggccag agggaaagac cccaaaacca acagcctcac agagcccaga    960

gatctccaca gcagcaacca tcaagacttc acaggccaca aaatcaggaa ccccagagcc   1020

aggaccccac cccaggtgaa gaggaagaaa tcctggagtc gagcctcttg ccaccccttg   1080

aggaggctgc ccatggaccc cgagggctga agggagagaa aggagagcct gcagtgttgg   1140

aacctggtat gctcgtggag gggccccctg gcccagaagg gcctgcggga ttgattggtc   1200

cccctggcat ccaggggaac ccaggcccag ttggagaccc tggagagagg ggcccccctg   1260

gccgagcagg gctccctgga tcagatgggg ctcctggtcc tcctggcaca tctctcatgc   1320

tcccattccg gtttggcagt ggtgggggtg acaagggccc tgtggtggcg gcccaggagg   1380

ctcaggccca ggcgatcctg cagcaggcga ggctggcgct ccgtggaccc cctggcccca   1440

tgggatacac agggcgccct ggacccttgg gccaacctgg gagccctggc ctgaaaggag   1500

agtctggaga cttaggacct cagggcccca gaggacctca gggcctcaca ggctccctgg   1560

gcaaggctgg gcgaaggggc cgggcaggtg ctgatggagc ccgagggatg cctggagatc   1620

ctggagtgaa gggtgaccga ggttttgatg gactcccagg gctccctgga gagaagggcc   1680

ataggggtga tactggtgcc cagggccttc ctggtccccc tggtgaggat ggagagaggg   1740

gagatgacgg ggagattggg cctcgagggc tgcctggaga gtcgggacct cgaggtctcc   1800

ttggccccaa aggcccacct ggtattcctg gaccccctgg cgtccgaggc atggatggtc   1860

cccagggccc caaagggagc ttgggacccc agggagagcc aggacctcct ggacaacagg   1920

gcacccctgg gacccagggt cttcccgggc cccagggtgc catcggccct catggagaga   1980

agggtcctca agggaagcca gggctccccg gcatgcctgg ctcagacgga cccccgggtc   2040

acccagggaa ggaaggtccc cctggaacca aaggaaacca gggtccctct ggacctcagg   2100

gacctctagg atacccagga cctcgagggg tcaagggtgt ggacggaatt cggggtctga   2160

agggtcataa gggtgagaag ggtgaggatg gctttcctgg gttcaaaggt gacataggcg   2220

tgaaaggtga caggggcgaa gttggagtcc ctggttccag gggagaggat ggtcctgagg   2280

ggccaaaggg acgcactgga ccgactggag accctgggcc cccagggctc atgggcgaga   2340

agggcaagct gggtgttcct ggtctgcctg gctatcctgg acgtcaggga cccaaggggt   2400

ccctaggatt tcctggcttt cctggtgcca gtggagagaa gggagcccgg ggcctgtcgg   2460

ggaagtcagg gcctcgggga gaacggggcc ccacgggtcc acggggtcag cggggacccc   2520

gaggtgccac tgggaagtct ggagctaagg gaacatctgg tggtgatggc ccccatggcc   2580

cccctggaga gaggggcctc cctggacctc agggtcccaa cgggtttcct ggaccgaaag   2640

gacccccggg cccccctggg aaggacgggc tgccgggaca cccaggccaa agaggagaag   2700

tgggtttcca agggaagacc ggcccccctg gtcctccagg agtggtggga cctcagggag   2760

cagcaggaga aaccggccct atgggggaga gaggtcaccc aggccccccg gggccccctg   2820

gagagcaggg actacctggg acagctggaa aagaaggaac aaagggtgac cctggtcccc   2880

ctggggcccc agggaaggat ggtcctgctg gtctgagggg attcccagga gagagaggcc   2940

tcccaggcac tgctggtgga cctggtttga aggggaatga aggtccgtct ggcccccctg   3000

gccctgcagg ctcccctggg gaacgaggtg cagcaggatc agggggaccc attggtcgcc   3060

aggggcgccc aggcccgcag ggtccccctg gagcagcagg agagaaaggt gtcccaggtg   3120

agaagggccc cattggcccg actggccgag atggagtgca gggtcctgtg gggcttcctg   3180

gtcctgctgg gcctccaggt gtggctggag aggatggaga caagggtgag gtgggggacc   3240

ccggacagaa gggcaccaaa gggaacaagg gtgaacatgg ccctcctgga ccccctggac   3300

ccattggtcc tgtggggcag cctggagcag cgggagcaga tggggagccc ggagctcggg   3360

gaccccaggg acactttgga gccaaaggtg atgaaggaac aagaggattc aatgggcccc   3420

caggacccat tggcctacag ggtttgccag gcccctctgg ggagaaggga gaaacaggag   3480

atgtgggtcc tatgggacca cctggccccc caggacctcg aggtccagct ggacccaatg   3540

gcgctgatgg cccacaaggt cccccaggag gtgttgggaa cctgggtccc cctggagaga   3600

agggggaacc aggagagtca ggatctccag ggatccaggg cgagccaggt gtcaagggtc   3660

cacgcgggga acgtggagag aaaggagagt cggggcagcc aggagagcca gggccaccag   3720

gcgctaaagg cccacagggc gatgatggcc ccaaagggaa ccctggtcct gttggttttc   3780

ctggtgaccc tggcccccct ggagaaggtg gccctcgggg ccaggatggt gctaagggtg   3840

accgaggcga ggatggtgag ccaggacagc ctggatcccc tggtcccacc ggggagaatg   3900

gacccccagg gccacttgga aagcgaggtc ctgctggctc gcctggttcc gaggggcgac   3960

aaggagggaa gggagccaag ggagatcctg gcgctatagg tgccccgggg aagacaggcc   4020

cggtgggtcc tgcaggccca gcagggaaac ctggccctga tggtctgagg gggctcccag   4080

gctcagtggg tcagcaaggc cgacctggag ctacaggcca ggctgggccc ccaggtcctg   4140

tgggaccccc agggctgcct ggtctccggg gcgatgctgg agccaaggga gagaagggcc   4200

acccaggtct cattggactg attgggcccc cgggtgagca gggagagaag ggagatcggg   4260

gacttcctgg gcctcagggc tcccctgggc agaagggtga gatgggtatc ccaggagcat   4320

ccggccccat tggtcctgga ggtccccccg gcctccccgg acctgctggc cccaaaggag   4380

ccaaaggagc cacaggccca ggcggaccca agggagagaa gggtgtgcag ggccctccag   4440

gacacccggg tcccccaggc gaggtgatcc agccactgcc cattcagatg cccaagaaga   4500

ctcggcgctc ggtggatgga agccgtctga tgcaggaaga tgaggccata ccgaccgggg   4560

gagcccccgg cagtcctggg gggctggagg agatctttgg ctcactcgac tccctgcggg   4620

aggagatcga gcagatgagg cggccaacag ggacccagga cagccctgct cgcacctgcc   4680

aggacctgaa gctgtgccac ccagagcttc ccgatggaga gtactgggtc gaccccaacc   4740

agggctgtgc tcgggatgcc ttccgagttt tctgcaactt cacagcaggg ggtgagacct   4800

gtgtgacgcc tagggatgac gtcacgcagt tctcttacgt ggactcagag ggctccccag   4860

tgggtgtggt ccagctcacc ttcctgcggc tgctcagcgt ctcagcccac caggacgtct   4920

cctacccctg ctctggagca gcccgtgacg gtcccctgag actccgtggg gccaatgagg   4980

atgagctgag cccggagact agcccctatg tcaaagaatt cagagatggc tgccagacac   5040

agcaaggccg gacggtgctg gaggtgcgaa cgcctgtgct ggagcagctg ccagtgctgg   5100

atgcctcctt ctcagacctg ggagccccac cgaggcgggg aggggtgctg ctggggcctg   5160

tctgcttcat gggataggac cgtctctgtc tgatcctgtc cattcggtac caggcccacc   5220

tggaatccca caacatcagc tctgtgccac ctcccaagag ggctcctcac tatctaggga   5280

gccctgggcc agggctggag agccctcagt cggggcaggc caggggaggg gtgaagtggt   5340

tgcctggaca ccccacggga ggagtggcat ctgggctctt ggccctccca cctggagcct   5400

gttacccgtt agagagctga gagcccttat ttaaaactca cctcccaatc accccaaaca   5460

aatggaagag aagagaaagg acatggcgta ttttgtattt aaaagtaatt gtattaatta   5520

tttaaagtgt ggaaagcaaa ataacaaaaa agagaaacgc caacaaaaaa tcagcagatg   5580

ttgaagacag gggtctcggg ggtgggctcc ggcacccaca tctgagtcag gactttcctc   5640

agtgactgtg tgtagggggg ttcagggctg aacccacctc cctcccacct tcctcccacc   5700

tcacctgtcg cacccactgt gaaagttgga atatgtggtc tccctggcct cagggctctg   5760

actctgccag ggtggggctc tctaacccac aggtgttggc tgcctggccc atgtgcccac   5820

tgtctcttcc acttggtctg ggtttggcag gcactgctgc tacttgaggg ccaggatgct   5880

cccccaggga agaaacggaa tagtgtgggg tgtgtgcagg gctgcatccg cagatggctg   5940

gaatattaaa attcttctat attggctggt aaattgccat ggccctgagc cactgagtat   6000

gttcattgcc acccctgtcc tcccctgggc acccctcact ttccctgatc ctgcaattaa   6060

agggttaatg tgtggcatat ggaagggact cccaggaccc tgtgcccagc ttccatgctg   6120

actgatggtt aaataatgtg attgtctcct cccagg                             6156


<210>  1704
<211>  1650
<212>  PRT
<213>  Homosapiens

<400>  1704

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Asp Pro Thr Pro Gly Glu 
            260                 265                 270         


Glu Glu Glu Ile Leu Glu Ser Ser Leu Leu Pro Pro Leu Glu Glu Ala 
        275                 280                 285             


Ala His Gly Pro Arg Gly Leu Lys Gly Glu Lys Gly Glu Pro Ala Val 
    290                 295                 300                 


Leu Glu Pro Gly Met Leu Val Glu Gly Pro Pro Gly Pro Glu Gly Pro 
305                 310                 315                 320 


Ala Gly Leu Ile Gly Pro Pro Gly Ile Gln Gly Asn Pro Gly Pro Val 
                325                 330                 335     


Gly Asp Pro Gly Glu Arg Gly Pro Pro Gly Arg Ala Gly Leu Pro Gly 
            340                 345                 350         


Ser Asp Gly Ala Pro Gly Pro Pro Gly Thr Ser Leu Met Leu Pro Phe 
        355                 360                 365             


Arg Phe Gly Ser Gly Gly Gly Asp Lys Gly Pro Val Val Ala Ala Gln 
    370                 375                 380                 


Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg 
385                 390                 395                 400 


Gly Pro Pro Gly Pro Met Gly Tyr Thr Gly Arg Pro Gly Pro Leu Gly 
                405                 410                 415     


Gln Pro Gly Ser Pro Gly Leu Lys Gly Glu Ser Gly Asp Leu Gly Pro 
            420                 425                 430         


Gln Gly Pro Arg Gly Pro Gln Gly Leu Thr Gly Ser Leu Gly Lys Ala 
        435                 440                 445             


Gly Arg Arg Gly Arg Ala Gly Ala Asp Gly Ala Arg Gly Met Pro Gly 
    450                 455                 460                 


Asp Pro Gly Val Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu 
465                 470                 475                 480 


Pro Gly Glu Lys Gly His Arg Gly Asp Thr Gly Ala Gln Gly Leu Pro 
                485                 490                 495     


Gly Pro Pro Gly Glu Asp Gly Glu Arg Gly Asp Asp Gly Glu Ile Gly 
            500                 505                 510         


Pro Arg Gly Leu Pro Gly Glu Ser Gly Pro Arg Gly Leu Leu Gly Pro 
        515                 520                 525             


Lys Gly Pro Pro Gly Ile Pro Gly Pro Pro Gly Val Arg Gly Met Asp 
    530                 535                 540                 


Gly Pro Gln Gly Pro Lys Gly Ser Leu Gly Pro Gln Gly Glu Pro Gly 
545                 550                 555                 560 


Pro Pro Gly Gln Gln Gly Thr Pro Gly Thr Gln Gly Leu Pro Gly Pro 
                565                 570                 575     


Gln Gly Ala Ile Gly Pro His Gly Glu Lys Gly Pro Gln Gly Lys Pro 
            580                 585                 590         


Gly Leu Pro Gly Met Pro Gly Ser Asp Gly Pro Pro Gly His Pro Gly 
        595                 600                 605             


Lys Glu Gly Pro Pro Gly Thr Lys Gly Asn Gln Gly Pro Ser Gly Pro 
    610                 615                 620                 


Gln Gly Pro Leu Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Val Asp 
625                 630                 635                 640 


Gly Ile Arg Gly Leu Lys Gly His Lys Gly Glu Lys Gly Glu Asp Gly 
                645                 650                 655     


Phe Pro Gly Phe Lys Gly Asp Ile Gly Val Lys Gly Asp Arg Gly Glu 
            660                 665                 670         


Val Gly Val Pro Gly Ser Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys 
        675                 680                 685             


Gly Arg Thr Gly Pro Thr Gly Asp Pro Gly Pro Pro Gly Leu Met Gly 
    690                 695                 700                 


Glu Lys Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg 
705                 710                 715                 720 


Gln Gly Pro Lys Gly Ser Leu Gly Phe Pro Gly Phe Pro Gly Ala Ser 
                725                 730                 735     


Gly Glu Lys Gly Ala Arg Gly Leu Ser Gly Lys Ser Gly Pro Arg Gly 
            740                 745                 750         


Glu Arg Gly Pro Thr Gly Pro Arg Gly Gln Arg Gly Pro Arg Gly Ala 
        755                 760                 765             


Thr Gly Lys Ser Gly Ala Lys Gly Thr Ser Gly Gly Asp Gly Pro His 
    770                 775                 780                 


Gly Pro Pro Gly Glu Arg Gly Leu Pro Gly Pro Gln Gly Pro Asn Gly 
785                 790                 795                 800 


Phe Pro Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu 
                805                 810                 815     


Pro Gly His Pro Gly Gln Arg Gly Glu Val Gly Phe Gln Gly Lys Thr 
            820                 825                 830         


Gly Pro Pro Gly Pro Pro Gly Val Val Gly Pro Gln Gly Ala Ala Gly 
        835                 840                 845             


Glu Thr Gly Pro Met Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro 
    850                 855                 860                 


Pro Gly Glu Gln Gly Leu Pro Gly Thr Ala Gly Lys Glu Gly Thr Lys 
865                 870                 875                 880 


Gly Asp Pro Gly Pro Pro Gly Ala Pro Gly Lys Asp Gly Pro Ala Gly 
                885                 890                 895     


Leu Arg Gly Phe Pro Gly Glu Arg Gly Leu Pro Gly Thr Ala Gly Gly 
            900                 905                 910         


Pro Gly Leu Lys Gly Asn Glu Gly Pro Ser Gly Pro Pro Gly Pro Ala 
        915                 920                 925             


Gly Ser Pro Gly Glu Arg Gly Ala Ala Gly Ser Gly Gly Pro Ile Gly 
    930                 935                 940                 


Arg Gln Gly Arg Pro Gly Pro Gln Gly Pro Pro Gly Ala Ala Gly Glu 
945                 950                 955                 960 


Lys Gly Val Pro Gly Glu Lys Gly Pro Ile Gly Pro Thr Gly Arg Asp 
                965                 970                 975     


Gly Val Gln Gly Pro Val Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly 
            980                 985                 990         


Val Ala Gly Glu Asp Gly Asp Lys  Gly Glu Val Gly Asp  Pro Gly Gln 
        995                 1000                 1005             


Lys Gly  Thr Lys Gly Asn Lys  Gly Glu His Gly Pro  Pro Gly Pro 
    1010                 1015                 1020             


Pro Gly  Pro Ile Gly Pro Val  Gly Gln Pro Gly Ala  Ala Gly Ala 
    1025                 1030                 1035             


Asp Gly  Glu Pro Gly Ala Arg  Gly Pro Gln Gly His  Phe Gly Ala 
    1040                 1045                 1050             


Lys Gly  Asp Glu Gly Thr Arg  Gly Phe Asn Gly Pro  Pro Gly Pro 
    1055                 1060                 1065             


Ile Gly  Leu Gln Gly Leu Pro  Gly Pro Ser Gly Glu  Lys Gly Glu 
    1070                 1075                 1080             


Thr Gly  Asp Val Gly Pro Met  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1085                 1090                 1095             


Arg Gly  Pro Ala Gly Pro Asn  Gly Ala Asp Gly Pro  Gln Gly Pro 
    1100                 1105                 1110             


Pro Gly  Gly Val Gly Asn Leu  Gly Pro Pro Gly Glu  Lys Gly Glu 
    1115                 1120                 1125             


Pro Gly  Glu Ser Gly Ser Pro  Gly Ile Gln Gly Glu  Pro Gly Val 
    1130                 1135                 1140             


Lys Gly  Pro Arg Gly Glu Arg  Gly Glu Lys Gly Glu  Ser Gly Gln 
    1145                 1150                 1155             


Pro Gly  Glu Pro Gly Pro Pro  Gly Ala Lys Gly Pro  Gln Gly Asp 
    1160                 1165                 1170             


Asp Gly  Pro Lys Gly Asn Pro  Gly Pro Val Gly Phe  Pro Gly Asp 
    1175                 1180                 1185             


Pro Gly  Pro Pro Gly Glu Gly  Gly Pro Arg Gly Gln  Asp Gly Ala 
    1190                 1195                 1200             


Lys Gly  Asp Arg Gly Glu Asp  Gly Glu Pro Gly Gln  Pro Gly Ser 
    1205                 1210                 1215             


Pro Gly  Pro Thr Gly Glu Asn  Gly Pro Pro Gly Pro  Leu Gly Lys 
    1220                 1225                 1230             


Arg Gly  Pro Ala Gly Ser Pro  Gly Ser Glu Gly Arg  Gln Gly Gly 
    1235                 1240                 1245             


Lys Gly  Ala Lys Gly Asp Pro  Gly Ala Ile Gly Ala  Pro Gly Lys 
    1250                 1255                 1260             


Thr Gly  Pro Val Gly Pro Ala  Gly Pro Ala Gly Lys  Pro Gly Pro 
    1265                 1270                 1275             


Asp Gly  Leu Arg Gly Leu Pro  Gly Ser Val Gly Gln  Gln Gly Arg 
    1280                 1285                 1290             


Pro Gly  Ala Thr Gly Gln Ala  Gly Pro Pro Gly Pro  Val Gly Pro 
    1295                 1300                 1305             


Pro Gly  Leu Pro Gly Leu Arg  Gly Asp Ala Gly Ala  Lys Gly Glu 
    1310                 1315                 1320             


Lys Gly  His Pro Gly Leu Ile  Gly Leu Ile Gly Pro  Pro Gly Glu 
    1325                 1330                 1335             


Gln Gly  Glu Lys Gly Asp Arg  Gly Leu Pro Gly Pro  Gln Gly Ser 
    1340                 1345                 1350             


Pro Gly  Gln Lys Gly Glu Met  Gly Ile Pro Gly Ala  Ser Gly Pro 
    1355                 1360                 1365             


Ile Gly  Pro Gly Gly Pro Pro  Gly Leu Pro Gly Pro  Ala Gly Pro 
    1370                 1375                 1380             


Lys Gly  Ala Lys Gly Ala Thr  Gly Pro Gly Gly Pro  Lys Gly Glu 
    1385                 1390                 1395             


Lys Gly  Val Gln Gly Pro Pro  Gly His Pro Gly Pro  Pro Gly Glu 
    1400                 1405                 1410             


Val Ile  Gln Pro Leu Pro Ile  Gln Met Pro Lys Lys  Thr Arg Arg 
    1415                 1420                 1425             


Ser Val  Asp Gly Ser Arg Leu  Met Gln Glu Asp Glu  Ala Ile Pro 
    1430                 1435                 1440             


Thr Gly  Gly Ala Pro Gly Ser  Pro Gly Gly Leu Glu  Glu Ile Phe 
    1445                 1450                 1455             


Gly Ser  Leu Asp Ser Leu Arg  Glu Glu Ile Glu Gln  Met Arg Arg 
    1460                 1465                 1470             


Pro Thr  Gly Thr Gln Asp Ser  Pro Ala Arg Thr Cys  Gln Asp Leu 
    1475                 1480                 1485             


Lys Leu  Cys His Pro Glu Leu  Pro Asp Gly Glu Tyr  Trp Val Asp 
    1490                 1495                 1500             


Pro Asn  Gln Gly Cys Ala Arg  Asp Ala Phe Arg Val  Phe Cys Asn 
    1505                 1510                 1515             


Phe Thr  Ala Gly Gly Glu Thr  Cys Val Thr Pro Arg  Asp Asp Val 
    1520                 1525                 1530             


Thr Gln  Phe Ser Tyr Val Asp  Ser Glu Gly Ser Pro  Val Gly Val 
    1535                 1540                 1545             


Val Gln  Leu Thr Phe Leu Arg  Leu Leu Ser Val Ser  Ala His Gln 
    1550                 1555                 1560             


Asp Val  Ser Tyr Pro Cys Ser  Gly Ala Ala Arg Asp  Gly Pro Leu 
    1565                 1570                 1575             


Arg Leu  Arg Gly Ala Asn Glu  Asp Glu Leu Ser Pro  Glu Thr Ser 
    1580                 1585                 1590             


Pro Tyr  Val Lys Glu Phe Arg  Asp Gly Cys Gln Thr  Gln Gln Gly 
    1595                 1600                 1605             


Arg Thr  Val Leu Glu Val Arg  Thr Pro Val Leu Glu  Gln Leu Pro 
    1610                 1615                 1620             


Val Leu  Asp Ala Ser Phe Ser  Asp Leu Gly Ala Pro  Pro Arg Arg 
    1625                 1630                 1635             


Gly Gly  Val Leu Leu Gly Pro  Val Cys Phe Met Gly  
    1640                 1645                 1650 


<210>  1705
<211>  2892
<212>  DNA
<213>  Homosapiens

<400>  1705
caaagatggc tgccacattg gcgctgtcat tttggtactg agcagagcga cgggcttaat     60

tcgacccaat ccaggccaga gtctttctct caggggcttc ctcgtgctca gctaatcctc    120

cgatcaatcc ttgggaatcc ctgggacctc ttcggtatcc ctactctcag ccagggatca    180

tgtcttgggc cgctcgcccg cccttcctcc ctcagcggca tgccgcaggg cagtgtgggc    240

cggtgggggt gcgaaaagaa atgcattgtg gggtcgcgtc ccggtggcgg cggcgacggc    300

cctggctgga tcccgcagcg gcggcggcgg cggcggtggc aggcggagaa caacaaaccc    360

cggagccgga gccaggggag gctggacggg acgggatggg cgacagcggg cgggactccc    420

gaagcccaga cagctcctcc ccaaatcccc ttccccaggg agtccctccc ccttctcctc    480

ctgggccacc cctaccccct tcaacagctc catcccttgg aggctctggg gccccacccc    540

cacccccgat gccaccaccc ccactgggct ctccctttcc agtcatcagt tcttccatgg    600

ggtcccctgg tctgccccct ccagctcccc caggattctc cgggcctgtc agcagccccc    660

agattaactc aacagtgtca ctccctgggg gtgggtctgg cccccctgaa gatgtgaagc    720

caccagtctt aggggtccgg ggcctgcact gtccaccccc tccaggtggc cctggggctg    780

gcaaacggct atgtgcaatc tgcggggaca gaagctcagg caaacactac ggggtttaca    840

gctgtgaggg ttgcaagggc ttcttcaaac gcaccatccg caaagacctt acatactctt    900

gccgggacaa caaagactgc acagtggaca agcgccagcg gaaccgctgt cagtactgcc    960

gctatcagaa gtgcctggcc actggcatga agagggaggc ggtacaggag gagcgtcagc   1020

ggggaaagga caaggatggg gatggggagg gggctggggg agcccccgag gagatgcctg   1080

tggacaggat cctggaggca gagcttgctg tggaacagaa gagtgaccag ggcgttgagg   1140

gtcctggggg aaccgggggt agcggcagca gcccaaatga ccctgtgact aacatctgtc   1200

aggcagctga caaacagcta ttcacgcttg ttgagtgggc gaagaggatc ccacactttt   1260

cctccttgcc tctggatgat caggtcatat tgctgcgggc aggctggaat gaactcctca   1320

ttgcctcctt ctcacaccga tccattgatg ttcgagatgg catcctcctt gccacaggtc   1380

ttcacgtgca ccgcaactca gcccattcag caggagtagg agccatcttt gatcgggtgc   1440

tgacagagct agtgtccaaa atgcgtgaca tgaggatgga caagacagag cttggctgcc   1500

tgagggcaat cattctgttt aatccagatg ccaagggcct ctccaaccct agtgaggtgg   1560

aggtcctgcg ggagaaagtg tatgcatcac tggagaccta ctgcaaacag aagtaccctg   1620

agcagcaggg acggtttgcc aagctgctgc tacgtcttcc tgccctccgg tccattggcc   1680

ttaagtgtct agagcatctg tttttcttca agctcattgg tgacaccccc atcgacacct   1740

tcctcatgga gatgcttgag gctccccatc aactggcctg agctcagacc cagacgtggt   1800

gcttctcaca ctggaggagc acacatccaa gagggactcc aagccctggg gcagggtggg   1860

gggccatgtt cccagaacct tgatggggtg agaagtacag ggcagaacca agaacataaa   1920

ccctccaagg gatctgcttg atatcccaag ttggaaggga ccccagatac ctgtgaggac   1980

tggttgtctc tcttcggtgg ccttgagtct ctgaatttgt cgggttctcc catgatttgg   2040

ggtgatttct caccctctgt ccttccccca gcacaaagca ctggccttgc ctccaggacc   2100

ttgcttcctt ctcatcttgc ctcattttgc ttcccatctg aagagtggaa atggggaact   2160

cccccagagg tggatactgg ggggcaggcc tcccaagctg atggacatga gagtagggcc   2220

ctgacaggcc ttcctcctct caaacctggc agatgggggc ctctctggaa gagggagggg   2280

ccctgtcact gtccagagtc tctttttaca cttcacctcc ttctgcagtc agactgaaat   2340

ataaaaaagg tggtggtggt ggtgaagggg ctggtggaga tgtaggaacc gatctgctat   2400

ttttaatttc ctgtgaggat agagacttgc agttagactc aaagaagtac tgtactttcc   2460

caggttgact aagaaatgcc agtggtggag gtgggtgttt gggaaaggca gggccctgaa   2520

atggcctgtc cctagggctc tccaagcact agccttccca gcttcccgcc gcccccccta   2580

tctcttcctg tctaacttgg ggaaggggcc tgggctgtga ggacagggcc cccacagggg   2640

atggtttcac gagtgtagtc ccggaggcct tccctttaca gctctcctcc agccctgggc   2700

acatagcata ggctggggac acaggatcct ggcctgagaa ttgaggggag gtggccagcc   2760

cgcagaggtg gggtgctggg gctgcatgat ttttgccctg cgtcccttct ctttggggct   2820

cctttcccct ctcatacata aaatcgcttt caaattaaaa tcgctgtttt ctggaaaaaa   2880

aaaaaaaaaa aa                                                       2892


<210>  1706
<211>  533
<212>  PRT
<213>  Homosapiens

<400>  1706

Met Ser Trp Ala Ala Arg Pro Pro Phe Leu Pro Gln Arg His Ala Ala 
1               5                   10                  15      


Gly Gln Cys Gly Pro Val Gly Val Arg Lys Glu Met His Cys Gly Val 
            20                  25                  30          


Ala Ser Arg Trp Arg Arg Arg Arg Pro Trp Leu Asp Pro Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Val Ala Gly Gly Glu Gln Gln Thr Pro Glu Pro Glu 
    50                  55                  60                  


Pro Gly Glu Ala Gly Arg Asp Gly Met Gly Asp Ser Gly Arg Asp Ser 
65                  70                  75                  80  


Arg Ser Pro Asp Ser Ser Ser Pro Asn Pro Leu Pro Gln Gly Val Pro 
                85                  90                  95      


Pro Pro Ser Pro Pro Gly Pro Pro Leu Pro Pro Ser Thr Ala Pro Ser 
            100                 105                 110         


Leu Gly Gly Ser Gly Ala Pro Pro Pro Pro Pro Met Pro Pro Pro Pro 
        115                 120                 125             


Leu Gly Ser Pro Phe Pro Val Ile Ser Ser Ser Met Gly Ser Pro Gly 
    130                 135                 140                 


Leu Pro Pro Pro Ala Pro Pro Gly Phe Ser Gly Pro Val Ser Ser Pro 
145                 150                 155                 160 


Gln Ile Asn Ser Thr Val Ser Leu Pro Gly Gly Gly Ser Gly Pro Pro 
                165                 170                 175     


Glu Asp Val Lys Pro Pro Val Leu Gly Val Arg Gly Leu His Cys Pro 
            180                 185                 190         


Pro Pro Pro Gly Gly Pro Gly Ala Gly Lys Arg Leu Cys Ala Ile Cys 
        195                 200                 205             


Gly Asp Arg Ser Ser Gly Lys His Tyr Gly Val Tyr Ser Cys Glu Gly 
    210                 215                 220                 


Cys Lys Gly Phe Phe Lys Arg Thr Ile Arg Lys Asp Leu Thr Tyr Ser 
225                 230                 235                 240 


Cys Arg Asp Asn Lys Asp Cys Thr Val Asp Lys Arg Gln Arg Asn Arg 
                245                 250                 255     


Cys Gln Tyr Cys Arg Tyr Gln Lys Cys Leu Ala Thr Gly Met Lys Arg 
            260                 265                 270         


Glu Ala Val Gln Glu Glu Arg Gln Arg Gly Lys Asp Lys Asp Gly Asp 
        275                 280                 285             


Gly Glu Gly Ala Gly Gly Ala Pro Glu Glu Met Pro Val Asp Arg Ile 
    290                 295                 300                 


Leu Glu Ala Glu Leu Ala Val Glu Gln Lys Ser Asp Gln Gly Val Glu 
305                 310                 315                 320 


Gly Pro Gly Gly Thr Gly Gly Ser Gly Ser Ser Pro Asn Asp Pro Val 
                325                 330                 335     


Thr Asn Ile Cys Gln Ala Ala Asp Lys Gln Leu Phe Thr Leu Val Glu 
            340                 345                 350         


Trp Ala Lys Arg Ile Pro His Phe Ser Ser Leu Pro Leu Asp Asp Gln 
        355                 360                 365             


Val Ile Leu Leu Arg Ala Gly Trp Asn Glu Leu Leu Ile Ala Ser Phe 
    370                 375                 380                 


Ser His Arg Ser Ile Asp Val Arg Asp Gly Ile Leu Leu Ala Thr Gly 
385                 390                 395                 400 


Leu His Val His Arg Asn Ser Ala His Ser Ala Gly Val Gly Ala Ile 
                405                 410                 415     


Phe Asp Arg Val Leu Thr Glu Leu Val Ser Lys Met Arg Asp Met Arg 
            420                 425                 430         


Met Asp Lys Thr Glu Leu Gly Cys Leu Arg Ala Ile Ile Leu Phe Asn 
        435                 440                 445             


Pro Asp Ala Lys Gly Leu Ser Asn Pro Ser Glu Val Glu Val Leu Arg 
    450                 455                 460                 


Glu Lys Val Tyr Ala Ser Leu Glu Thr Tyr Cys Lys Gln Lys Tyr Pro 
465                 470                 475                 480 


Glu Gln Gln Gly Arg Phe Ala Lys Leu Leu Leu Arg Leu Pro Ala Leu 
                485                 490                 495     


Arg Ser Ile Gly Leu Lys Cys Leu Glu His Leu Phe Phe Phe Lys Leu 
            500                 505                 510         


Ile Gly Asp Thr Pro Ile Asp Thr Phe Leu Met Glu Met Leu Glu Ala 
        515                 520                 525             


Pro His Gln Leu Ala 
    530             


<210>  1707
<211>  2358
<212>  DNA
<213>  Homosapiens

<400>  1707
ggagaggatc ccggagccgg tgagaattct ctgttttttc tctaccatcc tttccaggcc     60

ttttcctcac ctaatgagtc gtagagacga gggcccagag agtctgtaaa gtggctggtg    120

aaagattagt gtcccagggc cctacatccg ggaggtggtt cgggataaag agaactagtc    180

ttgggaacaa tgtaggtggg aacttaaggg aatgggagag cggcccatag aggtggacgg    240

agggcgcgat tggagtaaag cggaccctgt gtaggtatag agttgagtca agtggagtca    300

ctgcctctgt ccctctggtc agcgtgatgg ccagaggcct ggggggcccc cactgggtgg    360

ccgtgggact gctgacctgg gcgaccttgg ggcttctggt ggctggactc gggggtcatg    420

acgacctgca cgacgatctg caagaggact tccatggcca cagccacagg cactcacatg    480

aagatttcca ccatggtcac agccatgccc atggtcatgg ccacactcac gagagcatct    540

ggcatggaca tacccacgat cacgaccatg gacattcaca tgaggattta caccatggcc    600

atagccatgg ctactcccat gagagcctct accacagagg acatggacat gaccatgagc    660

atagccatgg aggctatggg gagtctgggg ctccaggcat caagcaggac ctggatgctg    720

tcactctctg ggcttatgca ctgggggcca cagtgctgat ctcagcagct ccattttttg    780

tcctcttcct tatccccgtg gagtcgaact ctccccggca tcgctctcta cttcagatct    840

tgctcagttt tgcttccggt gggctcctgg gagatgcttt cctgcacctc attcctcatg    900

ctcttgaacc tcattctcac cacactctgg agcaacccgg acatggacac tcccacagtg    960

gccagggccc cattctgtct gtgggcctgt gggttctcag tggaattgtt gcctttcttg   1020

tcgtggagaa atttgtgaga catgtgaaag gaggacatgg tcacagtcat ggacatggac   1080

acgctcacag tcatacacgt ggaagtcatg gacatggaag acaagagcgt tctaccaagg   1140

agaagcagag ctcagaggaa gaaggaaagg aaacaagagg ggttcagaag aggcgaggag   1200

ggagcacagt acccaaagat gggccagtga gacctcagaa cgctgaagaa gaaaaaagag   1260

gcttagacct gcgtgtgtcg gggtacctga atctggctgc tgacttggca cacaacttca   1320

ctgatggtct ggccattggg gcttcctttc gagggggccg gggactaggg atcctgacca   1380

caatgactgt cctgctacat gaagtgcccc acgaggtcgg ggactttgcc atcttggtcc   1440

agtctggctg caccaaaaag caggcgatgc gtctgcaact actgacagca gtaggggcac   1500

tggcaggcac agctgtgccc ttctcactga aggaggagca gtggacagtg aaattgcagg   1560

tggtgcaggt cctggctggg tcctgccatt tactgcaggt ggctttatct acgtagcaac   1620

agtgtctgtg ttgcccgagc tgctgaggga ggcatcacca ttgcaatcac ttctggaggt   1680

gctggggctg ctggggggag ttatcatgat ggtgctgatt gcccaccttg agtgaggggt   1740

ggataaacta ccctgcccca aacctctacc cctaactcca ggtcaggggt gcgtagaggt   1800

tgggggccct ggccagggac atctgccaaa ggaaggaact gtagcctggg agcaatggtt   1860

actttggcat tagggccttc aagggctggc agtcttacag aggctggagc ggtgagaatg   1920

agaggccaga gggaccatag tgttgggcac tgtctgacca tgttgcattt ggaaggctaa   1980

atggggccat gaagaaggct ggaagggaca gggggtgatg gcagcctacc tggtgtcccc   2040

taccccacct gttctcggag aaccaagttg ctacacagga agttctccaa ggtccagttt   2100

cctttctccc accagttggt ggaggcttca gggaagacca gagtcctgga cagagagggt   2160

aacaggagga gtcggggata aacatcaaac atcaatcgtg tgtcctgatt tgggagtgat   2220

tggggggatg gggtgggaga gggttaattg gtattctcat ggcctgattt tttttgtttc   2280

tattcctttt atatcactgt gtttgaatcg agggggaggg gtggtaaccg gaaataaaga   2340

cctccgatct tccgcccc                                                 2358


<210>  1708
<211>  429
<212>  PRT
<213>  Homosapiens

<400>  1708

Met Ala Arg Gly Leu Gly Gly Pro His Trp Val Ala Val Gly Leu Leu 
1               5                   10                  15      


Thr Trp Ala Thr Leu Gly Leu Leu Val Ala Gly Leu Gly Gly His Asp 
            20                  25                  30          


Asp Leu His Asp Asp Leu Gln Glu Asp Phe His Gly His Ser His Arg 
        35                  40                  45              


His Ser His Glu Asp Phe His His Gly His Ser His Ala His Gly His 
    50                  55                  60                  


Gly His Thr His Glu Ser Ile Trp His Gly His Thr His Asp His Asp 
65                  70                  75                  80  


His Gly His Ser His Glu Asp Leu His His Gly His Ser His Gly Tyr 
                85                  90                  95      


Ser His Glu Ser Leu Tyr His Arg Gly His Gly His Asp His Glu His 
            100                 105                 110         


Ser His Gly Gly Tyr Gly Glu Ser Gly Ala Pro Gly Ile Lys Gln Asp 
        115                 120                 125             


Leu Asp Ala Val Thr Leu Trp Ala Tyr Ala Leu Gly Ala Thr Val Leu 
    130                 135                 140                 


Ile Ser Ala Ala Pro Phe Phe Val Leu Phe Leu Ile Pro Val Glu Ser 
145                 150                 155                 160 


Asn Ser Pro Arg His Arg Ser Leu Leu Gln Ile Leu Leu Ser Phe Ala 
                165                 170                 175     


Ser Gly Gly Leu Leu Gly Asp Ala Phe Leu His Leu Ile Pro His Ala 
            180                 185                 190         


Leu Glu Pro His Ser His His Thr Leu Glu Gln Pro Gly His Gly His 
        195                 200                 205             


Ser His Ser Gly Gln Gly Pro Ile Leu Ser Val Gly Leu Trp Val Leu 
    210                 215                 220                 


Ser Gly Ile Val Ala Phe Leu Val Val Glu Lys Phe Val Arg His Val 
225                 230                 235                 240 


Lys Gly Gly His Gly His Ser His Gly His Gly His Ala His Ser His 
                245                 250                 255     


Thr Arg Gly Ser His Gly His Gly Arg Gln Glu Arg Ser Thr Lys Glu 
            260                 265                 270         


Lys Gln Ser Ser Glu Glu Glu Gly Lys Glu Thr Arg Gly Val Gln Lys 
        275                 280                 285             


Arg Arg Gly Gly Ser Thr Val Pro Lys Asp Gly Pro Val Arg Pro Gln 
    290                 295                 300                 


Asn Ala Glu Glu Glu Lys Arg Gly Leu Asp Leu Arg Val Ser Gly Tyr 
305                 310                 315                 320 


Leu Asn Leu Ala Ala Asp Leu Ala His Asn Phe Thr Asp Gly Leu Ala 
                325                 330                 335     


Ile Gly Ala Ser Phe Arg Gly Gly Arg Gly Leu Gly Ile Leu Thr Thr 
            340                 345                 350         


Met Thr Val Leu Leu His Glu Val Pro His Glu Val Gly Asp Phe Ala 
        355                 360                 365             


Ile Leu Val Gln Ser Gly Cys Thr Lys Lys Gln Ala Met Arg Leu Gln 
    370                 375                 380                 


Leu Leu Thr Ala Val Gly Ala Leu Ala Gly Thr Ala Val Pro Phe Ser 
385                 390                 395                 400 


Leu Lys Glu Glu Gln Trp Thr Val Lys Leu Gln Val Val Gln Val Leu 
                405                 410                 415     


Ala Gly Ser Cys His Leu Leu Gln Val Ala Leu Ser Thr 
            420                 425                 


<210>  1709
<211>  989
<212>  DNA
<213>  Homosapiens

<400>  1709
gggattccca cccacccaca gcccgccatg gcgtctcagc tccagaaccg actccgctcc     60

gcactggcct tggtcacagg tgcggggagc ggcatcggcc gagcggtcag tgtacgcctg    120

gccggagagg gggccaccgt agctgcctgc gacctggacc gggcagcggc acaggagacg    180

gtgcggctgc tgggcgggcc agggagcaag gaggggccgc cccgagggaa ccatgctgcc    240

ttccaggctg acgtgtctga ggccagggcc gccaggtgcc tgctggaaca agtgcaggcc    300

tgcttttctc gcccaccatc tgtcgttgtg tcctgtgcgg gcatcaccca ggatgagttt    360

ctgctgcaca tgtctgagga tgactgggac aaagtcatag ctgtcaacct caagggcacc    420

ttcctagtca ctcaggctgc agcacaagcc ctggtgtcca atggttgtcg tggttccatc    480

atcaacatca gtagcatcgt aggaaaggtg gggaacgtgg ggcagacaaa ctatgcagca    540

tccaaggctg gagtgattgg gctgacccag accgcagccc gggagcttgg acgacatggg    600

atccgctgta actctgtcct cccagggttc attgcaacac ccatgacaca gaaagtgcca    660

cagaaagtgg tggacaagat tactgaaatg atcccgatgg gacacttggg ggaccctgag    720

gatgtggcag atgtggtcgc attcttggca tctgaagata gtggatacat cacagggacc    780

tcagtggaag tcactggagg tcttttcatg taactgcctc aaggaccctg gactctgctc    840

acccccccac cactctgcct ggcctcctgc tgatgaggac tctaagttcc caggatacaa    900

aaggggtggc agtgtatggt tcaggaatgc tgaatatggg aagcaggggt gcttgtgacc    960

ctaataaatt ccaagtcctc ttccctgcc                                      989


<210>  1710
<211>  261
<212>  PRT
<213>  Homosapiens

<400>  1710

Met Ala Ser Gln Leu Gln Asn Arg Leu Arg Ser Ala Leu Ala Leu Val 
1               5                   10                  15      


Thr Gly Ala Gly Ser Gly Ile Gly Arg Ala Val Ser Val Arg Leu Ala 
            20                  25                  30          


Gly Glu Gly Ala Thr Val Ala Ala Cys Asp Leu Asp Arg Ala Ala Ala 
        35                  40                  45              


Gln Glu Thr Val Arg Leu Leu Gly Gly Pro Gly Ser Lys Glu Gly Pro 
    50                  55                  60                  


Pro Arg Gly Asn His Ala Ala Phe Gln Ala Asp Val Ser Glu Ala Arg 
65                  70                  75                  80  


Ala Ala Arg Cys Leu Leu Glu Gln Val Gln Ala Cys Phe Ser Arg Pro 
                85                  90                  95      


Pro Ser Val Val Val Ser Cys Ala Gly Ile Thr Gln Asp Glu Phe Leu 
            100                 105                 110         


Leu His Met Ser Glu Asp Asp Trp Asp Lys Val Ile Ala Val Asn Leu 
        115                 120                 125             


Lys Gly Thr Phe Leu Val Thr Gln Ala Ala Ala Gln Ala Leu Val Ser 
    130                 135                 140                 


Asn Gly Cys Arg Gly Ser Ile Ile Asn Ile Ser Ser Ile Val Gly Lys 
145                 150                 155                 160 


Val Gly Asn Val Gly Gln Thr Asn Tyr Ala Ala Ser Lys Ala Gly Val 
                165                 170                 175     


Ile Gly Leu Thr Gln Thr Ala Ala Arg Glu Leu Gly Arg His Gly Ile 
            180                 185                 190         


Arg Cys Asn Ser Val Leu Pro Gly Phe Ile Ala Thr Pro Met Thr Gln 
        195                 200                 205             


Lys Val Pro Gln Lys Val Val Asp Lys Ile Thr Glu Met Ile Pro Met 
    210                 215                 220                 


Gly His Leu Gly Asp Pro Glu Asp Val Ala Asp Val Val Ala Phe Leu 
225                 230                 235                 240 


Ala Ser Glu Asp Ser Gly Tyr Ile Thr Gly Thr Ser Val Glu Val Thr 
                245                 250                 255     


Gly Gly Leu Phe Met 
            260     


<210>  1711
<211>  1744
<212>  DNA
<213>  Homosapiens

<400>  1711
cagcgcccgg gccatggcgg cggcggtggc gggagctgct gtctgagcag cggttgcgga     60

ccgagcgaac ttggcccagg agcccgggcc tagggagagg cgcggcggcg gcgggagcgc    120

gaacggctgg agctggcctt cttcgccttc tcctcggctg tggagccctg gtggggggtc    180

tgcgcccggt caccatgacg acgccggcga atgcccagaa tgccagcaaa acgtgggaac    240

tgagtctgta tgagctgcac cggaccccgc aggaagccat aatggatggc acagagattg    300

ctgtttcccc tcggtcactg cattcagaac tcatgtgccc tatctgcctg gacatgctga    360

agaatacgat gaccaccaag gagtgcctcc acagattctg ctctgactgc attgtcacag    420

ccctacggag cgggaacaag gagtgtccta cctgccgaaa gaagctggtg tccaagcgat    480

ccctacggcc agaccccaac tttgatgccc tgatctctaa gatctatcct agccgggagg    540

aatacgaggc ccatcaagac cgagtgctta tccgcctgag ccgcctgcac aaccagcagg    600

cattgagctc cagcattgag gaggggctac gcatgcaggc catgcacagg gcccagcgtg    660

tgaggcggcc gataccaggg tcagatcaga ccacaacgat gagtgggggg gaaggagagc    720

ccggggaggg agaaggggat ggagaagatg tgagctcaga ctccgcccct gactctgccc    780

caggccctgc tcccaagcga ccccgtggag ggggcgcagg ggggagcagt gtagggacag    840

ggggaggcgg cactggtggg gtgggtgggg gtgccggttc ggaagactct ggtgaccggg    900

gagggactct gggaggggga acgctgggcc ccccaagccc tcctggggcc cccagccccc    960

cagagccagg tggagaaatt gagctcgtgt tccggcccca ccccctgctc gtggagaagg   1020

gagaatactg ccagacgagg tatgtgaaga caactgggaa tgccacagtg gaccacctct   1080

ccaagtactt ggccctgcgc attgccctcg agcggaggca acagcaggaa gcaggggagc   1140

caggagggcc tggagggggc gcctctgaca ccggaggacc tgatgggtgt ggcggggagg   1200

gtgggggtgc cggaggaggt gacggtcctg aggagcctgc tttgcccagc ctggagggcg   1260

tcagtgaaaa gcagtacacc atctacatcg cacctggagg cggggcgttc acgacgttga   1320

atggctcgct gaccctggag ctggtgaatg agaaattctg gaaggtgtcc cggccactgg   1380

agctgtgcta tgctcccacc aaggatccaa agtgacccca ccaggggaca gccagaggaa   1440

ggggaccatg gggtatccct gtgtcctggt ctatcacccc agcttctttg tcccccagta   1500

cccccagccc agccagccaa taagaggaca caaatgagga cacgtggctt ttatacaaag   1560

tatctatatg agattcttct atattgtaca gagtggggca aaacacgccc ccatctgctg   1620

ccttttctat tgccctgcaa cgtcccatct atacgaggtg ttggagaagg tgaagaaccc   1680

tcccattcac gcccgcctac caacaacaaa cgtgcttttt tcctctttga aacctgcaaa   1740

aaaa                                                                1744


<210>  1712
<211>  406
<212>  PRT
<213>  Homosapiens

<400>  1712

Met Thr Thr Pro Ala Asn Ala Gln Asn Ala Ser Lys Thr Trp Glu Leu 
1               5                   10                  15      


Ser Leu Tyr Glu Leu His Arg Thr Pro Gln Glu Ala Ile Met Asp Gly 
            20                  25                  30          


Thr Glu Ile Ala Val Ser Pro Arg Ser Leu His Ser Glu Leu Met Cys 
        35                  40                  45              


Pro Ile Cys Leu Asp Met Leu Lys Asn Thr Met Thr Thr Lys Glu Cys 
    50                  55                  60                  


Leu His Arg Phe Cys Ser Asp Cys Ile Val Thr Ala Leu Arg Ser Gly 
65                  70                  75                  80  


Asn Lys Glu Cys Pro Thr Cys Arg Lys Lys Leu Val Ser Lys Arg Ser 
                85                  90                  95      


Leu Arg Pro Asp Pro Asn Phe Asp Ala Leu Ile Ser Lys Ile Tyr Pro 
            100                 105                 110         


Ser Arg Glu Glu Tyr Glu Ala His Gln Asp Arg Val Leu Ile Arg Leu 
        115                 120                 125             


Ser Arg Leu His Asn Gln Gln Ala Leu Ser Ser Ser Ile Glu Glu Gly 
    130                 135                 140                 


Leu Arg Met Gln Ala Met His Arg Ala Gln Arg Val Arg Arg Pro Ile 
145                 150                 155                 160 


Pro Gly Ser Asp Gln Thr Thr Thr Met Ser Gly Gly Glu Gly Glu Pro 
                165                 170                 175     


Gly Glu Gly Glu Gly Asp Gly Glu Asp Val Ser Ser Asp Ser Ala Pro 
            180                 185                 190         


Asp Ser Ala Pro Gly Pro Ala Pro Lys Arg Pro Arg Gly Gly Gly Ala 
        195                 200                 205             


Gly Gly Ser Ser Val Gly Thr Gly Gly Gly Gly Thr Gly Gly Val Gly 
    210                 215                 220                 


Gly Gly Ala Gly Ser Glu Asp Ser Gly Asp Arg Gly Gly Thr Leu Gly 
225                 230                 235                 240 


Gly Gly Thr Leu Gly Pro Pro Ser Pro Pro Gly Ala Pro Ser Pro Pro 
                245                 250                 255     


Glu Pro Gly Gly Glu Ile Glu Leu Val Phe Arg Pro His Pro Leu Leu 
            260                 265                 270         


Val Glu Lys Gly Glu Tyr Cys Gln Thr Arg Tyr Val Lys Thr Thr Gly 
        275                 280                 285             


Asn Ala Thr Val Asp His Leu Ser Lys Tyr Leu Ala Leu Arg Ile Ala 
    290                 295                 300                 


Leu Glu Arg Arg Gln Gln Gln Glu Ala Gly Glu Pro Gly Gly Pro Gly 
305                 310                 315                 320 


Gly Gly Ala Ser Asp Thr Gly Gly Pro Asp Gly Cys Gly Gly Glu Gly 
                325                 330                 335     


Gly Gly Ala Gly Gly Gly Asp Gly Pro Glu Glu Pro Ala Leu Pro Ser 
            340                 345                 350         


Leu Glu Gly Val Ser Glu Lys Gln Tyr Thr Ile Tyr Ile Ala Pro Gly 
        355                 360                 365             


Gly Gly Ala Phe Thr Thr Leu Asn Gly Ser Leu Thr Leu Glu Leu Val 
    370                 375                 380                 


Asn Glu Lys Phe Trp Lys Val Ser Arg Pro Leu Glu Leu Cys Tyr Ala 
385                 390                 395                 400 


Pro Thr Lys Asp Pro Lys 
                405     


<210>  1713
<211>  2990
<212>  DNA
<213>  Homosapiens

<400>  1713
tccggggcta gtttgtgttt cagacttcca tatttccatt tgcagttggg tgaagtggtt     60

agagctgaaa ggggacagct ggagtcaaac aacttaactc aaatatctgg gaacgatttc    120

gcgctgagga agaccctttg ggacttgtag ctccactccg gggaacggac tcgccgggac    180

tgacagttgc cggaagtgag gctgcgggga atggccgccg ctgcgaccat ggcggctgcg    240

gcccgggaac tggtgttgcg ggctgggacc tcagatatgg aggaggaaga gggcccgctg    300

gcgggtggtc ctgggctcca ggaaccactg caacttgggg agttggatat cacttctgat    360

gaattcatcc tggatgaagt ggatgttcac attcaggcaa atctggagga tgagttagta    420

aaggaagctc ttaaaacggg tgtagatctc cgtcactatt caaagcaagt tgagctggag    480

ctacagcaga ttgaacagaa atccattcgg gattatattc aagagagtga gaatatagca    540

tctctacaca accagatcac agcctgtgat gctgtcctgg agcgaatgga gcagatgttg    600

ggagcttttc agagtgacct cagctccatc agctctgaga tccggacact gcaggaacag    660

tcaggagcca tgaacattcg acttcgaaat cgccaggcag ttcgggggaa acttggggag    720

cttgttgatg gtctggtggt gccttctgct ctggtcacgg caattctgga ggctccagtg    780

acagagccca ggttcttgga gcagctacag gagctggatg ccaaggcagc cgcagtcaga    840

gagcaggaag ctagaggcac agcagcctgc gcagatgtca gaggcgtgct cgatcggctc    900

cgggtcaagg cagtgacgaa gatccgagag tttatcctcc agaagattta ttccttcagg    960

aaacccatga ccaactatca gatcccccag acggccctgc tgaagtacag gttcttctat   1020

cagtttctgc tgggcaatga acgagcaaca gcaaaggaga tcagggatga atatgtggag   1080

acgctgagca agatttacct gtcttactac cgctcttacc tggggcggct catgaaggtg   1140

cagtatgagg aagtcgctga gaaagatgat ctaatgggtg tggaagatac agcaaagaaa   1200

ggattcttct caaagccatc gctccgcagc aggaacacca ttttcaccct aggaacccgc   1260

ggctctgtca tctcccccac tgaacttgag gcccccatcc tggtgcctca cacagcgcag   1320

cgcggagagc agaggtatcc atttgaggcc ctcttccgca gccagcacta cgccctccta   1380

gacaattcct gccgcgaata ccttttcatc tgtgaatttt ttgttgtgtc tggcccagct   1440

gcacacgacc tgttccatgc tgtcatgggc cgtacactca gcatgaccct gaaacacctg   1500

gattcttatc tagctgactg ctacgatgcc attgctgttt ttctctgtat ccacattgtt   1560

ctccggttcc gtaacattgc agcaaagagg gatgttcctg ccctggacag gtactgggaa   1620

caggtgcttg ccttgctatg gccacggttt gaactgatcc tggagatgaa tgttcagagc   1680

gtccgaagca ctgaccccca gcgcctaggg gggttggata ctcggcccca ctatatcaca   1740

cgccgctatg cagagttctc ctccgctctt gtcagtatca accagacaat tcctaatgaa   1800

cggaccatgc aattgctggg acagctgcag gtggaggtgg agaattttgt cctccgagtg   1860

gcagctgagt tctcctcaag gaaggagcag cttgtgtttc tgatcaacaa ctatgacatg   1920

atgctgggtg tgctgatgga gcgggctgca gatgacagca aagaggttga gagcttccag   1980

cagctgctca atgctcggac acaggaattc attgaagagt tgctgtctcc cccttttggg   2040

ggtttagtgg catttgtgaa ggaggctgag gctttgattg agcgtggaca ggctgagcga   2100

cttcgagggg aagaagcccg ggtaactcag ctgatccgtg gctttggtag ttcctggaaa   2160

tcatcagtgg aatctctgag tcaggatgta atgcggagtt tcaccaactt cagaaatggc   2220

accagtatca ttcagggagc gctgacccag ctgatccagc tctatcatcg cttccaccgg   2280

gtgctgtccc agccgcagct ccgagccctc cctgcccggg ctgagctcat caacattcac   2340

caccttatgg tggagctcaa gaagcataag cccaacttct gatgtgccag aaaccgccct   2400

gagatctgcc ggtcatctcc atggacttct gcaccccatt ccataccctt cttcacctgg   2460

ggtacccctt ccagttttcc ccttgcttcc caggcccttg acatggctta cctgccttca   2520

ctcccagcac cttgcccaac aggataagct ggatcccctt ggccttctga atatcccagt   2580

gtcttcaggt ttcccaagac cacttccctg tgggcttcca aaatggcctt tatcatttct   2640

ccagtctgtc accctccttt cctgctccca tacacccaag gcttgtttct tcccctgtaa   2700

aaaccactgc ctcaatctct ggttcactca actagtcacc atgtcctgag gcatgaagcc   2760

tcctcagctc ttggaattgc tggcaagggg tgactgcctc tgagtcattg tgtttttcaa   2820

agtgatttct tttctgtagc tttttgacct aagatctcag caatttgaac actaacctct   2880

cccctcctgg ctcaagaatt actccgaagt cagtctgcag aaaataaata tttagtatga   2940

catgacactt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa              2990


<210>  1714
<211>  723
<212>  PRT
<213>  Homosapiens

<400>  1714

Met Ala Ala Ala Ala Thr Met Ala Ala Ala Ala Arg Glu Leu Val Leu 
1               5                   10                  15      


Arg Ala Gly Thr Ser Asp Met Glu Glu Glu Glu Gly Pro Leu Ala Gly 
            20                  25                  30          


Gly Pro Gly Leu Gln Glu Pro Leu Gln Leu Gly Glu Leu Asp Ile Thr 
        35                  40                  45              


Ser Asp Glu Phe Ile Leu Asp Glu Val Asp Val His Ile Gln Ala Asn 
    50                  55                  60                  


Leu Glu Asp Glu Leu Val Lys Glu Ala Leu Lys Thr Gly Val Asp Leu 
65                  70                  75                  80  


Arg His Tyr Ser Lys Gln Val Glu Leu Glu Leu Gln Gln Ile Glu Gln 
                85                  90                  95      


Lys Ser Ile Arg Asp Tyr Ile Gln Glu Ser Glu Asn Ile Ala Ser Leu 
            100                 105                 110         


His Asn Gln Ile Thr Ala Cys Asp Ala Val Leu Glu Arg Met Glu Gln 
        115                 120                 125             


Met Leu Gly Ala Phe Gln Ser Asp Leu Ser Ser Ile Ser Ser Glu Ile 
    130                 135                 140                 


Arg Thr Leu Gln Glu Gln Ser Gly Ala Met Asn Ile Arg Leu Arg Asn 
145                 150                 155                 160 


Arg Gln Ala Val Arg Gly Lys Leu Gly Glu Leu Val Asp Gly Leu Val 
                165                 170                 175     


Val Pro Ser Ala Leu Val Thr Ala Ile Leu Glu Ala Pro Val Thr Glu 
            180                 185                 190         


Pro Arg Phe Leu Glu Gln Leu Gln Glu Leu Asp Ala Lys Ala Ala Ala 
        195                 200                 205             


Val Arg Glu Gln Glu Ala Arg Gly Thr Ala Ala Cys Ala Asp Val Arg 
    210                 215                 220                 


Gly Val Leu Asp Arg Leu Arg Val Lys Ala Val Thr Lys Ile Arg Glu 
225                 230                 235                 240 


Phe Ile Leu Gln Lys Ile Tyr Ser Phe Arg Lys Pro Met Thr Asn Tyr 
                245                 250                 255     


Gln Ile Pro Gln Thr Ala Leu Leu Lys Tyr Arg Phe Phe Tyr Gln Phe 
            260                 265                 270         


Leu Leu Gly Asn Glu Arg Ala Thr Ala Lys Glu Ile Arg Asp Glu Tyr 
        275                 280                 285             


Val Glu Thr Leu Ser Lys Ile Tyr Leu Ser Tyr Tyr Arg Ser Tyr Leu 
    290                 295                 300                 


Gly Arg Leu Met Lys Val Gln Tyr Glu Glu Val Ala Glu Lys Asp Asp 
305                 310                 315                 320 


Leu Met Gly Val Glu Asp Thr Ala Lys Lys Gly Phe Phe Ser Lys Pro 
                325                 330                 335     


Ser Leu Arg Ser Arg Asn Thr Ile Phe Thr Leu Gly Thr Arg Gly Ser 
            340                 345                 350         


Val Ile Ser Pro Thr Glu Leu Glu Ala Pro Ile Leu Val Pro His Thr 
        355                 360                 365             


Ala Gln Arg Gly Glu Gln Arg Tyr Pro Phe Glu Ala Leu Phe Arg Ser 
    370                 375                 380                 


Gln His Tyr Ala Leu Leu Asp Asn Ser Cys Arg Glu Tyr Leu Phe Ile 
385                 390                 395                 400 


Cys Glu Phe Phe Val Val Ser Gly Pro Ala Ala His Asp Leu Phe His 
                405                 410                 415     


Ala Val Met Gly Arg Thr Leu Ser Met Thr Leu Lys His Leu Asp Ser 
            420                 425                 430         


Tyr Leu Ala Asp Cys Tyr Asp Ala Ile Ala Val Phe Leu Cys Ile His 
        435                 440                 445             


Ile Val Leu Arg Phe Arg Asn Ile Ala Ala Lys Arg Asp Val Pro Ala 
    450                 455                 460                 


Leu Asp Arg Tyr Trp Glu Gln Val Leu Ala Leu Leu Trp Pro Arg Phe 
465                 470                 475                 480 


Glu Leu Ile Leu Glu Met Asn Val Gln Ser Val Arg Ser Thr Asp Pro 
                485                 490                 495     


Gln Arg Leu Gly Gly Leu Asp Thr Arg Pro His Tyr Ile Thr Arg Arg 
            500                 505                 510         


Tyr Ala Glu Phe Ser Ser Ala Leu Val Ser Ile Asn Gln Thr Ile Pro 
        515                 520                 525             


Asn Glu Arg Thr Met Gln Leu Leu Gly Gln Leu Gln Val Glu Val Glu 
    530                 535                 540                 


Asn Phe Val Leu Arg Val Ala Ala Glu Phe Ser Ser Arg Lys Glu Gln 
545                 550                 555                 560 


Leu Val Phe Leu Ile Asn Asn Tyr Asp Met Met Leu Gly Val Leu Met 
                565                 570                 575     


Glu Arg Ala Ala Asp Asp Ser Lys Glu Val Glu Ser Phe Gln Gln Leu 
            580                 585                 590         


Leu Asn Ala Arg Thr Gln Glu Phe Ile Glu Glu Leu Leu Ser Pro Pro 
        595                 600                 605             


Phe Gly Gly Leu Val Ala Phe Val Lys Glu Ala Glu Ala Leu Ile Glu 
    610                 615                 620                 


Arg Gly Gln Ala Glu Arg Leu Arg Gly Glu Glu Ala Arg Val Thr Gln 
625                 630                 635                 640 


Leu Ile Arg Gly Phe Gly Ser Ser Trp Lys Ser Ser Val Glu Ser Leu 
                645                 650                 655     


Ser Gln Asp Val Met Arg Ser Phe Thr Asn Phe Arg Asn Gly Thr Ser 
            660                 665                 670         


Ile Ile Gln Gly Ala Leu Thr Gln Leu Ile Gln Leu Tyr His Arg Phe 
        675                 680                 685             


His Arg Val Leu Ser Gln Pro Gln Leu Arg Ala Leu Pro Ala Arg Ala 
    690                 695                 700                 


Glu Leu Ile Asn Ile His His Leu Met Val Glu Leu Lys Lys His Lys 
705                 710                 715                 720 


Pro Asn Phe 
            


<210>  1715
<211>  549
<212>  DNA
<213>  Homosapiens

<400>  1715
ctctcttcca caggaggcct acacgccgcc gcttgtgctg cagccatgtc tctagtgatc     60

cctgaaaagt tccagcatat tttgcgagta ctcaacacca acatcgatgg gcggcggaaa    120

atagcctttg ccatcactgc cattaagggt gtgggccgaa gatatgctca tgtggtgttg    180

aggaaagcag acattgacct caccaagagg gcgggagaac tcactgagga tgaggtggaa    240

cgtgtgatca ccattatgca gaatccacgc cagtacaaga tcccagactg gttcttgaac    300

agacagaagg atgtaaagga tggaaaatac agccaggtcc tagccaatgg tctggacaac    360

aagctccgtg aagacctgga gcgactgaag aagattcggg cccatagagg gctgcgtcac    420

ttctggggcc ttcgtgtccg aggccagcac accaagacca ctggccgccg tggccgcacc    480

gtgggtgtgt ccaagaagaa ataagtctgt aggccttgtc tgttaataaa tagtttatat    540

acaaaaaaa                                                            549


<210>  1716
<211>  152
<212>  PRT
<213>  Homosapiens

<400>  1716

Met Ser Leu Val Ile Pro Glu Lys Phe Gln His Ile Leu Arg Val Leu 
1               5                   10                  15      


Asn Thr Asn Ile Asp Gly Arg Arg Lys Ile Ala Phe Ala Ile Thr Ala 
            20                  25                  30          


Ile Lys Gly Val Gly Arg Arg Tyr Ala His Val Val Leu Arg Lys Ala 
        35                  40                  45              


Asp Ile Asp Leu Thr Lys Arg Ala Gly Glu Leu Thr Glu Asp Glu Val 
    50                  55                  60                  


Glu Arg Val Ile Thr Ile Met Gln Asn Pro Arg Gln Tyr Lys Ile Pro 
65                  70                  75                  80  


Asp Trp Phe Leu Asn Arg Gln Lys Asp Val Lys Asp Gly Lys Tyr Ser 
                85                  90                  95      


Gln Val Leu Ala Asn Gly Leu Asp Asn Lys Leu Arg Glu Asp Leu Glu 
            100                 105                 110         


Arg Leu Lys Lys Ile Arg Ala His Arg Gly Leu Arg His Phe Trp Gly 
        115                 120                 125             


Leu Arg Val Arg Gly Gln His Thr Lys Thr Thr Gly Arg Arg Gly Arg 
    130                 135                 140                 


Thr Val Gly Val Ser Lys Lys Lys 
145                 150         


<210>  1717
<211>  1704
<212>  DNA
<213>  Homosapiens

<400>  1717
gaggcggggg aggggccgtg agtgccgcag tcggccagcc atggagcgga gcttgctggc     60

ggcgaggccg cggcgacaag gtagccaccc ccgcagcatg cctcgaccgc ggtccgcagc    120

tgcaccgcct ctccccgccc cccagggtgc gctggtcccg gtcgcgcgct cagacctccg    180

catcccgggc gtggtcggtt aagtccccgg ccgtgaccca ggcccgggga gctagtctcc    240

gcccttcgct cttacggatc ccctcggagt acgccgcacc atgcagctca ggctcttccg    300

gcgcctcctt ctcgccgctt tgctgctggt gatcgtctgg accctcttcg ggccttcggg    360

gttgggggag gagctgctga gcctctcact agcctccctg ctcccagccc ccgcctcacc    420

ggggccgccc ctggccctgc cccgcctctt gatccccaac caggaagctt gcagtggtcc    480

cggggcccct cccttcctgc tcatcctggt gtgcacggct ccggagaacc tgaaccagag    540

aaacgccatt cgggcttcgt ggggcgggct gcgcgaggcc cgggggctca gggtacagac    600

gctattcttg ctgggagagc cgaacgcaca gcaccccgtg tggggttccc aggggagtga    660

cctggcctcg gagtcagcag cccaggggga tatcttgcag gccgccttcc aggactccta    720

ccgcaacctc accctaaaga ccctcagcgg gctgaactgg gctgagaaac actgccccat    780

ggcccgatac gtcctcaaga cggacgatga tgtgtatgtc aacgtccctg aactggtatc    840

agagctggtc ttgcgagggg gccgttgggg gcaatgggag agaagcacgg aaccccagag    900

agaggctgag caggaaggag gccaggtttt gcacagcgag gaagtgcctc ttctgtactt    960

gggccgggtg cactggcgcg tgaacccctc tcggacaccg gggggcaggc accgcgtatc   1020

agaggagcag tggcctcaca cctggggccc ctttccaccc tatgcctcag gcacggggta   1080

tgtgctgtca gcgtctgctg tgcagctcat tctcaaggtg gccagccggg caccccttct   1140

cccattagag gatgtctttg tgggggtaag tgcccgacga ggaggcctcg ccccaacaca   1200

gtgtgtcaag ctggctggtg ccacccacta cccgctagac cggtgctgct atgggaaatt   1260

cctgctgacg tcccacaggc tggacccctg gaagatgcag gaagcctgga agctggtggg   1320

tggctctgac ggggaaagga ctgcgccctt ttgctcctgg ttccagggag tcctgggcat   1380

cctgcggtgt cgagcaatag cctggcttca gagctgagag tgcctggggc cacaggaaag   1440

gcaggaacag gaccttctct ctcccaggcc caacgcaggg gccctcactg gctgcagctg   1500

atctgtttcc ttataccaga tcctcagtct cactaaagac agcgatatgg gagacaccca   1560

ggggcctggc ccgccagccc aaaagatggt catcgggaag agaaaaagaa aaaaatgctg   1620

cagttgttct ctcaagctag ggcagaagag gggtgtcaag ctcctcaata aacttgtctc   1680

cacttcaaaa aaaaaaaaaa aaaa                                          1704


<210>  1718
<211>  378
<212>  PRT
<213>  Homosapiens

<400>  1718

Met Gln Leu Arg Leu Phe Arg Arg Leu Leu Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      


Val Ile Val Trp Thr Leu Phe Gly Pro Ser Gly Leu Gly Glu Glu Leu 
            20                  25                  30          


Leu Ser Leu Ser Leu Ala Ser Leu Leu Pro Ala Pro Ala Ser Pro Gly 
        35                  40                  45              


Pro Pro Leu Ala Leu Pro Arg Leu Leu Ile Pro Asn Gln Glu Ala Cys 
    50                  55                  60                  


Ser Gly Pro Gly Ala Pro Pro Phe Leu Leu Ile Leu Val Cys Thr Ala 
65                  70                  75                  80  


Pro Glu Asn Leu Asn Gln Arg Asn Ala Ile Arg Ala Ser Trp Gly Gly 
                85                  90                  95      


Leu Arg Glu Ala Arg Gly Leu Arg Val Gln Thr Leu Phe Leu Leu Gly 
            100                 105                 110         


Glu Pro Asn Ala Gln His Pro Val Trp Gly Ser Gln Gly Ser Asp Leu 
        115                 120                 125             


Ala Ser Glu Ser Ala Ala Gln Gly Asp Ile Leu Gln Ala Ala Phe Gln 
    130                 135                 140                 


Asp Ser Tyr Arg Asn Leu Thr Leu Lys Thr Leu Ser Gly Leu Asn Trp 
145                 150                 155                 160 


Ala Glu Lys His Cys Pro Met Ala Arg Tyr Val Leu Lys Thr Asp Asp 
                165                 170                 175     


Asp Val Tyr Val Asn Val Pro Glu Leu Val Ser Glu Leu Val Leu Arg 
            180                 185                 190         


Gly Gly Arg Trp Gly Gln Trp Glu Arg Ser Thr Glu Pro Gln Arg Glu 
        195                 200                 205             


Ala Glu Gln Glu Gly Gly Gln Val Leu His Ser Glu Glu Val Pro Leu 
    210                 215                 220                 


Leu Tyr Leu Gly Arg Val His Trp Arg Val Asn Pro Ser Arg Thr Pro 
225                 230                 235                 240 


Gly Gly Arg His Arg Val Ser Glu Glu Gln Trp Pro His Thr Trp Gly 
                245                 250                 255     


Pro Phe Pro Pro Tyr Ala Ser Gly Thr Gly Tyr Val Leu Ser Ala Ser 
            260                 265                 270         


Ala Val Gln Leu Ile Leu Lys Val Ala Ser Arg Ala Pro Leu Leu Pro 
        275                 280                 285             


Leu Glu Asp Val Phe Val Gly Val Ser Ala Arg Arg Gly Gly Leu Ala 
    290                 295                 300                 


Pro Thr Gln Cys Val Lys Leu Ala Gly Ala Thr His Tyr Pro Leu Asp 
305                 310                 315                 320 


Arg Cys Cys Tyr Gly Lys Phe Leu Leu Thr Ser His Arg Leu Asp Pro 
                325                 330                 335     


Trp Lys Met Gln Glu Ala Trp Lys Leu Val Gly Gly Ser Asp Gly Glu 
            340                 345                 350         


Arg Thr Ala Pro Phe Cys Ser Trp Phe Gln Gly Val Leu Gly Ile Leu 
        355                 360                 365             


Arg Cys Arg Ala Ile Ala Trp Leu Gln Ser 
    370                 375             


<210>  1719
<211>  2065
<212>  DNA
<213>  Homosapiens

<400>  1719
gctgagaaga gttttgcacg tggatcgccg ttcgggtggg cgagatggag acagccccca     60

agccgggcaa ggatgtcccg cccaagaaag acaaacttca gaccaagaga aagaaaccgc    120

ggcgatactg ggaggaagag accgttccga ccacagccgg agcctctcca gggcctcctc    180

gtaacaagaa gaatcgggag ctccgtcctc agagaccaaa aaatgcttac atcttaaaga    240

agtctcggat ctctaagaag cctcaggtcc cgaagaaacc ccgagaatgg aagaacccgg    300

agtcccagcg cggcttgtcc ggggcccaag atccattccc aggccccgcc cccgtccctg    360

tggaagtggt ccagaagttc tgtcgcattg acaaatcccg aaagctacca cattctaaag    420

ccaaaactcg aagccgactt gaggtggctg aagctgagga agaggaaaca agtatcaaag    480

ctgctcgttc tgagctgctg cttgctgaag aacctgggtt tctggaaggg gaggatgggg    540

aagacacagc aaagatatgc caggctgaca ttgtggaggc tgtggacatt gcaagtgcag    600

ccaagcactt tgacttgaat ctgcggcagt ttggacccta cagactaaac tactctcgaa    660

ctggaagaca cctggctttt ggagggcgcc gaggtcatgt ggctgccctt gattgggtaa    720

caaagaagct tatgtgcgag atcaacgtca tggaggcggt gcgggacatc cggtttctcc    780

attctgaggc actgcttgct gttgctcaga accgctggct ccacatctat gacaatcagg    840

gcattgagct ccactgtatc cgccgctgtg accgagtaac acggcttgag ttcctgccct    900

tccacttcct cctggctaca gcttcagaaa cagggtttct aacctacctg gatgtgtcag    960

tggggaagat tgtggcagct ctgaatgctc gagctgggcg gctcgatgtt atgagtcaga   1020

acccttacaa tgccgtcatc catctcggac acagcaatgg tactgtgtct ttatggagtc   1080

cagctatgaa ggagccactg gcaaagattc tctgtcatcg tggtggggtc cgggctgtgg   1140

cagtagattc tacaggcacg tacatggcca cctctggcct agaccaccag ctgaagatct   1200

ttgacttgcg agggacgtac cagcctctga gcactcggac cctgccccat ggagcagggc   1260

acctggcctt ctcccagagg ggactgctgg tggcgggaat gggtgacgtt gtcaacatct   1320

gggcagggca gggcaaggcc agcccaccct cccttgaaca gccctacctc acccaccggc   1380

tctcaggccc tgtgcatggc cttcagttct gcccctttga agatgtgctg ggggtggggc   1440

acactggggg catcaccagc atgctggtcc ctggggccgg tgagcccaac ttcgatggcc   1500

tggagagtaa tccatacaga agccggaagc agcgccagga gtgggaggtg aaggccctgc   1560

tagagaaggt acctgcagag cttatttgtc tggacccacg agccctggcc gaggtggatg   1620

tcatctccct ggagcaggga aagaaggagc agatagagag gctgggctat gacccgcagg   1680

ctaaggctcc cttccagcca aagccaaagc agaagggccg cagctccacg gcaagcctgg   1740

tgaagaggaa gaggaaggtc atggatgagg aacacaggga caaggtccgg cagagccttc   1800

agcagcagca tcataaggag gcgaaggcca agcccacggg ggcccggcca tctgccctgg   1860

acagatttgt gcgctgagcc agactccagg gttgcctggg aacagtctct ccccaagatc   1920

acctgtaggg aaatgagtgt tccctggaac aaggaggtgg gggcagtgtg gccccttccc   1980

caactggggg tggacagctg tctcctgggg tgggttggta ttaaagagga aagcgatttt   2040

ttggaaaaaa aaaaaaaaaa aaaaa                                         2065


<210>  1720
<211>  610
<212>  PRT
<213>  Homosapiens

<400>  1720

Met Glu Thr Ala Pro Lys Pro Gly Lys Asp Val Pro Pro Lys Lys Asp 
1               5                   10                  15      


Lys Leu Gln Thr Lys Arg Lys Lys Pro Arg Arg Tyr Trp Glu Glu Glu 
            20                  25                  30          


Thr Val Pro Thr Thr Ala Gly Ala Ser Pro Gly Pro Pro Arg Asn Lys 
        35                  40                  45              


Lys Asn Arg Glu Leu Arg Pro Gln Arg Pro Lys Asn Ala Tyr Ile Leu 
    50                  55                  60                  


Lys Lys Ser Arg Ile Ser Lys Lys Pro Gln Val Pro Lys Lys Pro Arg 
65                  70                  75                  80  


Glu Trp Lys Asn Pro Glu Ser Gln Arg Gly Leu Ser Gly Ala Gln Asp 
                85                  90                  95      


Pro Phe Pro Gly Pro Ala Pro Val Pro Val Glu Val Val Gln Lys Phe 
            100                 105                 110         


Cys Arg Ile Asp Lys Ser Arg Lys Leu Pro His Ser Lys Ala Lys Thr 
        115                 120                 125             


Arg Ser Arg Leu Glu Val Ala Glu Ala Glu Glu Glu Glu Thr Ser Ile 
    130                 135                 140                 


Lys Ala Ala Arg Ser Glu Leu Leu Leu Ala Glu Glu Pro Gly Phe Leu 
145                 150                 155                 160 


Glu Gly Glu Asp Gly Glu Asp Thr Ala Lys Ile Cys Gln Ala Asp Ile 
                165                 170                 175     


Val Glu Ala Val Asp Ile Ala Ser Ala Ala Lys His Phe Asp Leu Asn 
            180                 185                 190         


Leu Arg Gln Phe Gly Pro Tyr Arg Leu Asn Tyr Ser Arg Thr Gly Arg 
        195                 200                 205             


His Leu Ala Phe Gly Gly Arg Arg Gly His Val Ala Ala Leu Asp Trp 
    210                 215                 220                 


Val Thr Lys Lys Leu Met Cys Glu Ile Asn Val Met Glu Ala Val Arg 
225                 230                 235                 240 


Asp Ile Arg Phe Leu His Ser Glu Ala Leu Leu Ala Val Ala Gln Asn 
                245                 250                 255     


Arg Trp Leu His Ile Tyr Asp Asn Gln Gly Ile Glu Leu His Cys Ile 
            260                 265                 270         


Arg Arg Cys Asp Arg Val Thr Arg Leu Glu Phe Leu Pro Phe His Phe 
        275                 280                 285             


Leu Leu Ala Thr Ala Ser Glu Thr Gly Phe Leu Thr Tyr Leu Asp Val 
    290                 295                 300                 


Ser Val Gly Lys Ile Val Ala Ala Leu Asn Ala Arg Ala Gly Arg Leu 
305                 310                 315                 320 


Asp Val Met Ser Gln Asn Pro Tyr Asn Ala Val Ile His Leu Gly His 
                325                 330                 335     


Ser Asn Gly Thr Val Ser Leu Trp Ser Pro Ala Met Lys Glu Pro Leu 
            340                 345                 350         


Ala Lys Ile Leu Cys His Arg Gly Gly Val Arg Ala Val Ala Val Asp 
        355                 360                 365             


Ser Thr Gly Thr Tyr Met Ala Thr Ser Gly Leu Asp His Gln Leu Lys 
    370                 375                 380                 


Ile Phe Asp Leu Arg Gly Thr Tyr Gln Pro Leu Ser Thr Arg Thr Leu 
385                 390                 395                 400 


Pro His Gly Ala Gly His Leu Ala Phe Ser Gln Arg Gly Leu Leu Val 
                405                 410                 415     


Ala Gly Met Gly Asp Val Val Asn Ile Trp Ala Gly Gln Gly Lys Ala 
            420                 425                 430         


Ser Pro Pro Ser Leu Glu Gln Pro Tyr Leu Thr His Arg Leu Ser Gly 
        435                 440                 445             


Pro Val His Gly Leu Gln Phe Cys Pro Phe Glu Asp Val Leu Gly Val 
    450                 455                 460                 


Gly His Thr Gly Gly Ile Thr Ser Met Leu Val Pro Gly Ala Gly Glu 
465                 470                 475                 480 


Pro Asn Phe Asp Gly Leu Glu Ser Asn Pro Tyr Arg Ser Arg Lys Gln 
                485                 490                 495     


Arg Gln Glu Trp Glu Val Lys Ala Leu Leu Glu Lys Val Pro Ala Glu 
            500                 505                 510         


Leu Ile Cys Leu Asp Pro Arg Ala Leu Ala Glu Val Asp Val Ile Ser 
        515                 520                 525             


Leu Glu Gln Gly Lys Lys Glu Gln Ile Glu Arg Leu Gly Tyr Asp Pro 
    530                 535                 540                 


Gln Ala Lys Ala Pro Phe Gln Pro Lys Pro Lys Gln Lys Gly Arg Ser 
545                 550                 555                 560 


Ser Thr Ala Ser Leu Val Lys Arg Lys Arg Lys Val Met Asp Glu Glu 
                565                 570                 575     


His Arg Asp Lys Val Arg Gln Ser Leu Gln Gln Gln His His Lys Glu 
            580                 585                 590         


Ala Lys Ala Lys Pro Thr Gly Ala Arg Pro Ser Ala Leu Asp Arg Phe 
        595                 600                 605             


Val Arg 
    610 


<210>  1721
<211>  605
<212>  DNA
<213>  Homosapiens

<400>  1721
attactactg aaggaagaac gtgagtaggc cagatcagaa aagggagctc aggtaccttc     60

cagagagtga gacccagcgc ccttgtctcg cacccagtag gctttcatcc ccgccatggc    120

ggagctgatc cagaagaagc tacagggaga agtggagaaa tatcaacagc tacagaagga    180

cttaagtaaa tccatgtcgg ggaggcagaa acttgaagca caactaacag aaaataatat    240

cgtgaaagag gaactggccc tgctggatgg gtccaacgtg gtctttaaac ttctgggtcc    300

ggtgctagtc aaacaggagc tgggggaggc tcgggccaca gtagggaaga ggctggacta    360

tatcacagct gaaattaagc gatacgaatc ccagcttcgg gatcttgagc ggcagtcaga    420

gcaacagagg gagacccttg ctcagctgca gcaggagttc cagcgggccc aggcagcaaa    480

ggcaggggct cctggcaagg cctgacccca tggtgggggg aggggagggg aggggaggga    540

atgaggcagc tctaggatct atactgtagc taataaaatg taaaaacacc tggcaaaaaa    600

aaaaa                                                                605


<210>  1722
<211>  129
<212>  PRT
<213>  Homosapiens

<400>  1722

Met Ala Glu Leu Ile Gln Lys Lys Leu Gln Gly Glu Val Glu Lys Tyr 
1               5                   10                  15      


Gln Gln Leu Gln Lys Asp Leu Ser Lys Ser Met Ser Gly Arg Gln Lys 
            20                  25                  30          


Leu Glu Ala Gln Leu Thr Glu Asn Asn Ile Val Lys Glu Glu Leu Ala 
        35                  40                  45              


Leu Leu Asp Gly Ser Asn Val Val Phe Lys Leu Leu Gly Pro Val Leu 
    50                  55                  60                  


Val Lys Gln Glu Leu Gly Glu Ala Arg Ala Thr Val Gly Lys Arg Leu 
65                  70                  75                  80  


Asp Tyr Ile Thr Ala Glu Ile Lys Arg Tyr Glu Ser Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Arg Gln Ser Glu Gln Gln Arg Glu Thr Leu Ala Gln Leu Gln 
            100                 105                 110         


Gln Glu Phe Gln Arg Ala Gln Ala Ala Lys Ala Gly Ala Pro Gly Lys 
        115                 120                 125             


Ala 
    


<210>  1723
<211>  2918
<212>  DNA
<213>  Homosapiens

<400>  1723
acggaaaagc cggggagggg actcggtccg gggccggaga ccgacggcaa cagcggctca     60

ggacccacgc tgcccccacc cctcccgagc aggcgccccc atggcccgac cccgctgatt    120

ccttcactcg gccatgctcc cgcggcccct gcggctgctt ttggacacga gcccccccgg    180

gggagtcgta ctgagcagct tccgaagccg ggaccccgaa gagggtgggg gcccaggtgg    240

cctggtcgtg ggcggggggc aggaggaaga ggaggaggaa gaagaagagg cccctgtgtc    300

cgtctgggat gaggaggagg atggtgccgt gtttaccgtc acaagccgcc aatatcgacc    360

tcttgatccc ttggtcccta tgcctccccc acgttcctcc cgacggctcc gagctggcac    420

tctggaggcc ctggtcagac acctactgga tacccggaca tcagggactg atgtgagctt    480

catgtcagcc ttcctggcta cccaccgggc cttcacctcc acgcctgcct tgctagggct    540

tatggctgac aggctggaag cccttgaatc tcatcctacc gacgaactag agaggacaac    600

agaggtagcc atctctgtac tgtcaacctg gctggcctct caccctgagg attttggctc    660

tgaggccaag ggtcagcttg accggcttga gagcttctta cttcagacag ggtatgcagc    720

agggaagggt gttggggggg gcagcgctga cctcatccgc aatctccggt cccgggtgga    780

cccccaggcc cccgaccttc ctaagcccct ggccctcccc ggcgatcccc ctgctgaccc    840

cacggatgtc ctggtgttcc tcgctgacca cttggccgaa cagctgaccc tgctagatgc    900

ggaacttttt ctcaatttga tcccctctca gtgcctggga ggcctgtggg gtcacagaga    960

ccggccagga cattctcacc tctgcccatc tgtccgagct actgtcacac agtttaacaa   1020

ggtggcaggg gcagtggtta gttctgtcct gggggctact tccactggag agggacctgg   1080

ggaggtgacc atacggccac tccgtccccc acagagggcc cggctcctgg agaagtggat   1140

ccgcgtggca gaggagtgcc ggctgctccg aaacttctct tcagtttatg ccgtggtgtc   1200

agccctgcag tccagcccca tccacaggct tcgggcagcc tggggggaag caaccaggga   1260

cagcctcaga gtcttttcca gcctctgcca gattttctcc gaggaggata attattccca   1320

gagtcgggag ctgctcgtgc aggaggtgaa gctgcagtct cctctggagc cacactccaa   1380

gaaggccccg aggtctggct cccggggtgg gggtgtggtc ccataccttg gcaccttcct   1440

gaaggacctt gtgatgctgg atgcagcctc caaggatgag ttggagaatg gatacatcaa   1500

ttttgacaag cggaggaagg agtttgcagt cctttctgag ttgcgacggc tccagaatga   1560

atgtcgtggc tataacctcc aacctgacca tgatatccag aggtggctac aggggctccg   1620

gccactgaca gaggctcaga gccatcgtgt atcctgtgag gtggagccac ctggttccag   1680

tgaccctcct gccccacggg tgcttcggcc aacattggtc atctcgcagt ggacagaggt   1740

tttgggctct gttggggtcc ctaccccgct tgtgtcctgt gaccggccca gtactggggg   1800

agatgaggcg cctacaactc ctgctcctct gctgactcgg ctggcccagc acatgaagtg   1860

gccatctgtc tcgtcactag actctgcctt ggaaagcagt ccatccctgc acagtccagc   1920

tgaccccagc cacctctccc caccagcctc ctcccctagg ccttctcgag gtcaccgccg   1980

ctcagcctcc tgtggctccc cgctgagtgg gggtgcagaa gaggcctccg gggggactgg   2040

atatggggga gagggatctg ggccaggggc ctctgattgc cgtatcatcc gagtccagat   2100

ggagttgggg gaagatggca gtgtctataa gagcattttg gtgacaagcc aggacaaggc   2160

tccaagtgtc atcagtcgtg tccttaagaa aaacaatcgt gactctgcag tggcttcaga   2220

gtatgagctg gtacagctgc taccagggga gcgagagctg actatcccag cctcggctaa   2280

tgtattctac gccatggatg gagcttcaca cgatttcctc ctgcggcagc ggcgaaggtc   2340

ctctactgct acacctggcg tcaccagtgg cccgtctgcc tcaggaactc ctccgagtga   2400

gggaggaggg ggctcctttc ccaggatcaa ggccacaggg aggaagattg cacgggcact   2460

gttctgagga ggaagccccg ttggcttaca gaagtcatgg tgttcatacc agatgtgggt   2520

agccatcctg aatggtggca attatatcac attgagacag aaattcagaa agggagccag   2580

ccaccctggg gcagtgaagt gccactggtt taccagacag ctgagaaatc cagccctgtg   2640

ggaactggtg tcttataacc aagttggata cctgtgtata gcttcccacc ttccatgagt   2700

gcagcacaca ggtagtgctg gaaaaacgca tcagtttctg attcttggcc atatcctaac   2760

atgcaagggc caagcaaagg cttcaaggct ctgagcccca gggcagaggg gaatggcaaa   2820

atgtaggtcc tcgcaggagc tcttcttccc actctggggg tttctatcac tgtgacaaca   2880

ctaagataat aaaccaaaac actacctgaa aaaaaaaa                           2918


<210>  1724
<211>  777
<212>  PRT
<213>  Homosapiens

<400>  1724

Met Leu Pro Arg Pro Leu Arg Leu Leu Leu Asp Thr Ser Pro Pro Gly 
1               5                   10                  15      


Gly Val Val Leu Ser Ser Phe Arg Ser Arg Asp Pro Glu Glu Gly Gly 
            20                  25                  30          


Gly Pro Gly Gly Leu Val Val Gly Gly Gly Gln Glu Glu Glu Glu Glu 
        35                  40                  45              


Glu Glu Glu Glu Ala Pro Val Ser Val Trp Asp Glu Glu Glu Asp Gly 
    50                  55                  60                  


Ala Val Phe Thr Val Thr Ser Arg Gln Tyr Arg Pro Leu Asp Pro Leu 
65                  70                  75                  80  


Val Pro Met Pro Pro Pro Arg Ser Ser Arg Arg Leu Arg Ala Gly Thr 
                85                  90                  95      


Leu Glu Ala Leu Val Arg His Leu Leu Asp Thr Arg Thr Ser Gly Thr 
            100                 105                 110         


Asp Val Ser Phe Met Ser Ala Phe Leu Ala Thr His Arg Ala Phe Thr 
        115                 120                 125             


Ser Thr Pro Ala Leu Leu Gly Leu Met Ala Asp Arg Leu Glu Ala Leu 
    130                 135                 140                 


Glu Ser His Pro Thr Asp Glu Leu Glu Arg Thr Thr Glu Val Ala Ile 
145                 150                 155                 160 


Ser Val Leu Ser Thr Trp Leu Ala Ser His Pro Glu Asp Phe Gly Ser 
                165                 170                 175     


Glu Ala Lys Gly Gln Leu Asp Arg Leu Glu Ser Phe Leu Leu Gln Thr 
            180                 185                 190         


Gly Tyr Ala Ala Gly Lys Gly Val Gly Gly Gly Ser Ala Asp Leu Ile 
        195                 200                 205             


Arg Asn Leu Arg Ser Arg Val Asp Pro Gln Ala Pro Asp Leu Pro Lys 
    210                 215                 220                 


Pro Leu Ala Leu Pro Gly Asp Pro Pro Ala Asp Pro Thr Asp Val Leu 
225                 230                 235                 240 


Val Phe Leu Ala Asp His Leu Ala Glu Gln Leu Thr Leu Leu Asp Ala 
                245                 250                 255     


Glu Leu Phe Leu Asn Leu Ile Pro Ser Gln Cys Leu Gly Gly Leu Trp 
            260                 265                 270         


Gly His Arg Asp Arg Pro Gly His Ser His Leu Cys Pro Ser Val Arg 
        275                 280                 285             


Ala Thr Val Thr Gln Phe Asn Lys Val Ala Gly Ala Val Val Ser Ser 
    290                 295                 300                 


Val Leu Gly Ala Thr Ser Thr Gly Glu Gly Pro Gly Glu Val Thr Ile 
305                 310                 315                 320 


Arg Pro Leu Arg Pro Pro Gln Arg Ala Arg Leu Leu Glu Lys Trp Ile 
                325                 330                 335     


Arg Val Ala Glu Glu Cys Arg Leu Leu Arg Asn Phe Ser Ser Val Tyr 
            340                 345                 350         


Ala Val Val Ser Ala Leu Gln Ser Ser Pro Ile His Arg Leu Arg Ala 
        355                 360                 365             


Ala Trp Gly Glu Ala Thr Arg Asp Ser Leu Arg Val Phe Ser Ser Leu 
    370                 375                 380                 


Cys Gln Ile Phe Ser Glu Glu Asp Asn Tyr Ser Gln Ser Arg Glu Leu 
385                 390                 395                 400 


Leu Val Gln Glu Val Lys Leu Gln Ser Pro Leu Glu Pro His Ser Lys 
                405                 410                 415     


Lys Ala Pro Arg Ser Gly Ser Arg Gly Gly Gly Val Val Pro Tyr Leu 
            420                 425                 430         


Gly Thr Phe Leu Lys Asp Leu Val Met Leu Asp Ala Ala Ser Lys Asp 
        435                 440                 445             


Glu Leu Glu Asn Gly Tyr Ile Asn Phe Asp Lys Arg Arg Lys Glu Phe 
    450                 455                 460                 


Ala Val Leu Ser Glu Leu Arg Arg Leu Gln Asn Glu Cys Arg Gly Tyr 
465                 470                 475                 480 


Asn Leu Gln Pro Asp His Asp Ile Gln Arg Trp Leu Gln Gly Leu Arg 
                485                 490                 495     


Pro Leu Thr Glu Ala Gln Ser His Arg Val Ser Cys Glu Val Glu Pro 
            500                 505                 510         


Pro Gly Ser Ser Asp Pro Pro Ala Pro Arg Val Leu Arg Pro Thr Leu 
        515                 520                 525             


Val Ile Ser Gln Trp Thr Glu Val Leu Gly Ser Val Gly Val Pro Thr 
    530                 535                 540                 


Pro Leu Val Ser Cys Asp Arg Pro Ser Thr Gly Gly Asp Glu Ala Pro 
545                 550                 555                 560 


Thr Thr Pro Ala Pro Leu Leu Thr Arg Leu Ala Gln His Met Lys Trp 
                565                 570                 575     


Pro Ser Val Ser Ser Leu Asp Ser Ala Leu Glu Ser Ser Pro Ser Leu 
            580                 585                 590         


His Ser Pro Ala Asp Pro Ser His Leu Ser Pro Pro Ala Ser Ser Pro 
        595                 600                 605             


Arg Pro Ser Arg Gly His Arg Arg Ser Ala Ser Cys Gly Ser Pro Leu 
    610                 615                 620                 


Ser Gly Gly Ala Glu Glu Ala Ser Gly Gly Thr Gly Tyr Gly Gly Glu 
625                 630                 635                 640 


Gly Ser Gly Pro Gly Ala Ser Asp Cys Arg Ile Ile Arg Val Gln Met 
                645                 650                 655     


Glu Leu Gly Glu Asp Gly Ser Val Tyr Lys Ser Ile Leu Val Thr Ser 
            660                 665                 670         


Gln Asp Lys Ala Pro Ser Val Ile Ser Arg Val Leu Lys Lys Asn Asn 
        675                 680                 685             


Arg Asp Ser Ala Val Ala Ser Glu Tyr Glu Leu Val Gln Leu Leu Pro 
    690                 695                 700                 


Gly Glu Arg Glu Leu Thr Ile Pro Ala Ser Ala Asn Val Phe Tyr Ala 
705                 710                 715                 720 


Met Asp Gly Ala Ser His Asp Phe Leu Leu Arg Gln Arg Arg Arg Ser 
                725                 730                 735     


Ser Thr Ala Thr Pro Gly Val Thr Ser Gly Pro Ser Ala Ser Gly Thr 
            740                 745                 750         


Pro Pro Ser Glu Gly Gly Gly Gly Ser Phe Pro Arg Ile Lys Ala Thr 
        755                 760                 765             


Gly Arg Lys Ile Ala Arg Ala Leu Phe 
    770                 775         


<210>  1725
<211>  3629
<212>  DNA
<213>  Homosapiens

<400>  1725
ctggagagga tctacccggg tccctgcctg gccagtgggg aaacaccggt cccccaggca     60

ccttcaccta accagagcgg ggatttccac cgcccctcat gccgcccttt ggaggaaagt    120

gaaagtgaaa ggaggaagag gaggcttcat ggctgaggag gtcgcagcgc catgaagtcc    180

ctgtctctgc tcctcgctgt ggctttgggc ctggcgaccg ccgtctcagc aggacccgcg    240

gtgatcgagt gttggttcgt ggaggatgcg agcggaaagg gcctggccaa gagacccggt    300

gcactgctgt tgcgccaggg accgggggaa ccgccgcccc ggccggacct cgaccctgag    360

ctctatctca gtgtacacga ccccgcgggc gccctccagg ctgccttcag gcggtatccc    420

cggggcgccc ccgcaccaca ctgcgagatg agccgcttcg tgcctctccc cgcctctgcg    480

aaatgggcca gcggcctgac ccccgcgcag aactgcccgc gggccctgga tggggcttgg    540

ctgatggtca gcatatccag cccagtcctc agcctctcca gcctcttgcg accacagcca    600

gagcctcagc aggagcctgt tctcatcacc atggcaacag tggtactgac tgtcctcacc    660

cacacccctg cccctcgagt gagactggga caagatgctc tgctggactt gagctttgcc    720

tacatgcccc ccacctccga ggccgcctca tctctggctc cgggtccccc tccctttggg    780

ctagagtggc gacgccagca cctgggtaag ggacatctgc tcctggctgc aactcctggg    840

ctgaatggcc agatgccagc agcccaagaa ggggccgtgg catttgctgc ttgggatgat    900

gatgagccat ggggcccatg gaccggaaat gggaccttct ggctgcctac agttcaaccc    960

tttcaggagg gcacctatct ggccaccata cacctgccat acctgcaagg acaggtcacc   1020

ctggagcttg ctgtgtacaa accccccaaa gtgtccctga tgccagcaac ccttgcacgg   1080

gccgccccag gggaggcacc cccggaattg ctctgccttg tgtcccactt ctacccttct   1140

gggggcctgg aggtggagtg ggaactccgg ggtggcccag ggggccgctc tcagaaggcc   1200

gaggggcaga ggtggctctc ggccctgcgc caccattccg atggctctgt cagcctctct   1260

gggcacttgc agccgccccc agtcaccact gagcagcatg gggcacgcta tgcctgtcga   1320

attcaccatc ccagcctgcc tgcctcgggg cgcagcgctg aggtcaccct ggaggtagca   1380

ggtctttcag ggccctccct tgaggacagc gtaggccttt tcctgtctgc ctttcttctg   1440

cttgggctct tcaaggcact gggctgggct gctgtctacc tgtccacctg caaggattca   1500

aagaagaaag cagagtgagg gcactcactg ccatcctgtg gaagccacca tcatctctgg   1560

cccaagcttc tgtagtagct ccctaaaata ataccctatc atctgctcct aatccctcca   1620

atctctctcc actgagtggc tggaatgctt tttttttttt ctttcactta tataagggat   1680

aatttttctt tttttttttt ttttgagacg gagtctcact cttccgccca ggctgcagtg   1740

cagtggcatg atcttggctt actgcaacct ccgcctcctg ggttcaagca attctgtggc   1800

ttcagcctcc ggagtagctg ggattacagg cacatgccac cacacccagt gaatttttgt   1860

atttttagta gagacggggt ttcaccatgt tggccaggct ggtcttgaat tcctgacctc   1920

aggtgatctg cccacctcag cctcccaaag tgctgggatt acaggcgtga gccaccacac   1980

caggcccgag aaatgctttt ttaaaaaaca cacatcttat ggcattcacc ttcttggagc   2040

tctaggacag tggttctcaa aatttttttc tctcaggacc tcttaaaaat catcaaggac   2100

cccaaaaagc ttttgggtat gtgggttata gctatcaata tttatggtac tagaacttaa   2160

aagtgagaaa aatttaaaac acgagaatac ataggcacac attctattca tcgtgggaac   2220

catggtgtca atacatatca tgtagcttct gaaaaactcc actgtacact tatagaatga   2280

agaaggcaaa aaactttttt tttttttttt ttgagacgga gtctcgctct gtcgcccagg   2340

ctggagtgca gtggcgcgat ctcggctcac tgcaagctcc gcctctcggg ttcacgccat   2400

tctcctgcct cagcctccca agtagctcgg actacaggcg tcctccacca tgcctggcta   2460

atattttgta ttttttagta gagacggggt ttcaccgtgt tagccaggat ggtctcgatc   2520

tcctaacctg gtgatccgcc cgcctcggcc tcccaaagta ttgggattac ccgcgtgagc   2580

caccgcgccc ggctgcaaat aatctttctt tttttctgag acagagtctc gctctgttgc   2640

ccaggctgga gtgcagtggc acgatctcgg ctcacggcac gctccgcctc ccgggttcac   2700

gccattctcc tgcctcagct tcccgagtag ctgggactac aggggcccgc caccacgccc   2760

ggctaacttt ttgtgttttt agtagagacg gggtttcacc gtgttagcca ggatggtctc   2820

gatctcctga ccttgtgatc tgcccgcctc ggcctcccaa agtgctggga ttacaggcgt   2880

gagccaccgc gcccggcggc gaaacacgat attgtactaa catcttaatt ttgttataaa   2940

atctcacaaa ccccctgaca tagtctcaga gatctgtagg gccgaggtta catttggaga   3000

acccgtactc tagggccaaa tccattcttc ttgccctggc tcacttgtcc cccccaccgc   3060

cccgcgctgg agccactgcc tagttcttca gccctagatg gtgctcgcca gacctcctct   3120

caatgctcat cacacacagg gctattcctt tcctccaatg aaccaaacgc ctcccgccca   3180

cctccaggtc ccagtcctct gttccctttg cctggtccac ccttgccctc cctgggtcgc   3240

agacgaggtc ggcctcgtca ttccccgcag accgccgcgc gtccctcttg tgcggttcac   3300

cacagttgta tttaagtgat cgtgtgagtc gtcgttaaat gcctgtctcc ccgcggatca   3360

tgggctcctc gaggacaggg actggcctgt ctgtccactg ctgtaacccc gcgccggcat   3420

agggacctaa ggcccactgg agggcgctca tcaagtagct gctggatgtt gacgaaggaa   3480

gcggcggcgc agctcaggga tctccgagtc aggacggtcg gccagaccca cggggtaacg   3540

ggtctaatcg tgtaggaata aagctgtatt ccagtgcttc caaaaaaaaa aaaaaaaaaa   3600

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                     3629


<210>  1726
<211>  448
<212>  PRT
<213>  Homosapiens

<400>  1726

Met Lys Ser Leu Ser Leu Leu Leu Ala Val Ala Leu Gly Leu Ala Thr 
1               5                   10                  15      


Ala Val Ser Ala Gly Pro Ala Val Ile Glu Cys Trp Phe Val Glu Asp 
            20                  25                  30          


Ala Ser Gly Lys Gly Leu Ala Lys Arg Pro Gly Ala Leu Leu Leu Arg 
        35                  40                  45              


Gln Gly Pro Gly Glu Pro Pro Pro Arg Pro Asp Leu Asp Pro Glu Leu 
    50                  55                  60                  


Tyr Leu Ser Val His Asp Pro Ala Gly Ala Leu Gln Ala Ala Phe Arg 
65                  70                  75                  80  


Arg Tyr Pro Arg Gly Ala Pro Ala Pro His Cys Glu Met Ser Arg Phe 
                85                  90                  95      


Val Pro Leu Pro Ala Ser Ala Lys Trp Ala Ser Gly Leu Thr Pro Ala 
            100                 105                 110         


Gln Asn Cys Pro Arg Ala Leu Asp Gly Ala Trp Leu Met Val Ser Ile 
        115                 120                 125             


Ser Ser Pro Val Leu Ser Leu Ser Ser Leu Leu Arg Pro Gln Pro Glu 
    130                 135                 140                 


Pro Gln Gln Glu Pro Val Leu Ile Thr Met Ala Thr Val Val Leu Thr 
145                 150                 155                 160 


Val Leu Thr His Thr Pro Ala Pro Arg Val Arg Leu Gly Gln Asp Ala 
                165                 170                 175     


Leu Leu Asp Leu Ser Phe Ala Tyr Met Pro Pro Thr Ser Glu Ala Ala 
            180                 185                 190         


Ser Ser Leu Ala Pro Gly Pro Pro Pro Phe Gly Leu Glu Trp Arg Arg 
        195                 200                 205             


Gln His Leu Gly Lys Gly His Leu Leu Leu Ala Ala Thr Pro Gly Leu 
    210                 215                 220                 


Asn Gly Gln Met Pro Ala Ala Gln Glu Gly Ala Val Ala Phe Ala Ala 
225                 230                 235                 240 


Trp Asp Asp Asp Glu Pro Trp Gly Pro Trp Thr Gly Asn Gly Thr Phe 
                245                 250                 255     


Trp Leu Pro Thr Val Gln Pro Phe Gln Glu Gly Thr Tyr Leu Ala Thr 
            260                 265                 270         


Ile His Leu Pro Tyr Leu Gln Gly Gln Val Thr Leu Glu Leu Ala Val 
        275                 280                 285             


Tyr Lys Pro Pro Lys Val Ser Leu Met Pro Ala Thr Leu Ala Arg Ala 
    290                 295                 300                 


Ala Pro Gly Glu Ala Pro Pro Glu Leu Leu Cys Leu Val Ser His Phe 
305                 310                 315                 320 


Tyr Pro Ser Gly Gly Leu Glu Val Glu Trp Glu Leu Arg Gly Gly Pro 
                325                 330                 335     


Gly Gly Arg Ser Gln Lys Ala Glu Gly Gln Arg Trp Leu Ser Ala Leu 
            340                 345                 350         


Arg His His Ser Asp Gly Ser Val Ser Leu Ser Gly His Leu Gln Pro 
        355                 360                 365             


Pro Pro Val Thr Thr Glu Gln His Gly Ala Arg Tyr Ala Cys Arg Ile 
    370                 375                 380                 


His His Pro Ser Leu Pro Ala Ser Gly Arg Ser Ala Glu Val Thr Leu 
385                 390                 395                 400 


Glu Val Ala Gly Leu Ser Gly Pro Ser Leu Glu Asp Ser Val Gly Leu 
                405                 410                 415     


Phe Leu Ser Ala Phe Leu Leu Leu Gly Leu Phe Lys Ala Leu Gly Trp 
            420                 425                 430         


Ala Ala Val Tyr Leu Ser Thr Cys Lys Asp Ser Lys Lys Lys Ala Glu 
        435                 440                 445             


<210>  1727
<211>  2404
<212>  DNA
<213>  Homosapiens

<400>  1727
ctggagagga tctacccggg tccctgcctg gccagtgggg aaacaccggt cccccaggca     60

ccttcaccta accagagcgg ggatttccac cgcccctcat gccgcccttt ggaggaaagt    120

gaaagtgaaa ggaggaagag gaggcttcat ggctgaggag gtcgcagcgc catgaagtcc    180

ctgtctctgc tcctcgctgt ggctttgggc ctggcgaccg ccgtctcagc aggacccgcg    240

gtgatcgagt gttggttcgt ggaggatgcg agcggaaagg gcctggccaa gagacccggt    300

gcactgctgt tgcgccaggg accgggggaa ccgccgcccc ggccggacct cgaccctgag    360

ctctatctca gtgtacacga ccccgcgggc gccctccagg ctgccttcag gcggtatccc    420

cggggcgccc ccgcaccaca ctgcgagatg agccgcttcg tgcctctccc cgcctctgcg    480

aaatgggcca gcggcctgac ccccgcgcag aactgcccgc gggccctgga tggggcttgg    540

ctgatggtca gcatatccag cccagtcctc agcctctcca gcctcttgcg accacagcca    600

gagcctcagc aggagcctgt tctcatcacc atggcaacag tggtactgac tgtcctcacc    660

cacacccctg cccctcgagt gagactggga caagatgctc tgctggactt gagctttgcc    720

tacatgcccc ccacctccga ggccgcctca tctctggctc cgggtccccc tccctttggg    780

ctagagtggc gacgccagca cctgggtaag ggacatctgc tcctggctgc aactcctggg    840

ctgaatggcc agatgccagc agcccaagaa ggggccgtgg catttgctgc ttgggatgat    900

gatgagccat ggggcccatg gaccggaaat gggaccttct ggctgcctac agttcaaccc    960

tttcaggagg gcacctatct ggccaccata cacctgccat acctgcaagg acaggtcacc   1020

ctggagcttg ctgtgtacag tgagttgggg gacagaggtc tccaggggta gagggtgggc   1080

actggattgt ggggaccgta atagggggag ggatgatgga taagagggtg cctgggcaag   1140

taagtagaga tagaaagagg ttcctgggag ttagaggggt aatgggaggc tagaagtttc   1200

ctggaaattt gaggggcttt gacatgggta tttctgtgac gcaccaatgg agagacagtg   1260

ggttccctat ttcaggagaa gaaacctaac cttctttagt tctgaggaag ccagcaggca   1320

aactgagggt ctcttaggga ggacagtatg gactgatttc cctatgctca tttcgtcctc   1380

tttccccaga accccccaaa gtgtccctga tgccagcaac ccttgcacgg gccgccccag   1440

gggaggcacc cccggaattg ctctgccttg tgtcccactt ctacccttct gggggcctgg   1500

aggtggagtg ggaactccgg ggtggcccag ggggccgctc tcagaaggcc gaggggcaga   1560

ggtggctctc ggccctgcgc caccattccg atggctctgt cagcctctct gggcacttgc   1620

agccgccccc agtcaccact gagcagcatg gggcacgcta tgcctgtcga attcaccatc   1680

ccagcctgcc tgcctcgggg cgcagcgctg aggtcaccct ggaggtagca ggtaagagct   1740

gggagctctg cggaatctga gccagcaccc aggaagacag gagctcactc tcaccccttc   1800

tgcctgccag gtctttcagg gccctccctt gaggacagcg taggcctttt cctgtctgcc   1860

tttcttctgc ttgggctctt caaggcactg ggctgggctg gtaagtgtca gccctaccct   1920

gaccatgacc tgaggttggt ggactttccc cacctactcc caagagcctg acacccatcc   1980

ctctgccctc cacctctacc actccagcat cccatccctt ctcaatcttt ccccacagct   2040

gtctacctgt ccacctgcaa ggattcaaag aaggtacagt gctccacctc tctgtatctt   2100

tcccttgtca ctttatctcc tcatcctatc tcaaaaccca tggagggagg ctgctggtgt   2160

ggtaggcaga acctaggctt ggaattcaca ctgatctggg ttaaaacctg gcactatatc   2220

ctaactgtag gactctttga gcatgctact taatctatat gtttccttgg gtgtagggat   2280

tttaaaaagt tacttaggca gtgctgtcca atagaaagat aatgcaagcc acatatgtaa   2340

atttaaatac tctagtactc acattaaaaa aataagcaga aacaggtaaa aaaaaaaaaa   2400

aaaa                                                                2404


<210>  1728
<211>  299
<212>  PRT
<213>  Homosapiens

<400>  1728

Met Lys Ser Leu Ser Leu Leu Leu Ala Val Ala Leu Gly Leu Ala Thr 
1               5                   10                  15      


Ala Val Ser Ala Gly Pro Ala Val Ile Glu Cys Trp Phe Val Glu Asp 
            20                  25                  30          


Ala Ser Gly Lys Gly Leu Ala Lys Arg Pro Gly Ala Leu Leu Leu Arg 
        35                  40                  45              


Gln Gly Pro Gly Glu Pro Pro Pro Arg Pro Asp Leu Asp Pro Glu Leu 
    50                  55                  60                  


Tyr Leu Ser Val His Asp Pro Ala Gly Ala Leu Gln Ala Ala Phe Arg 
65                  70                  75                  80  


Arg Tyr Pro Arg Gly Ala Pro Ala Pro His Cys Glu Met Ser Arg Phe 
                85                  90                  95      


Val Pro Leu Pro Ala Ser Ala Lys Trp Ala Ser Gly Leu Thr Pro Ala 
            100                 105                 110         


Gln Asn Cys Pro Arg Ala Leu Asp Gly Ala Trp Leu Met Val Ser Ile 
        115                 120                 125             


Ser Ser Pro Val Leu Ser Leu Ser Ser Leu Leu Arg Pro Gln Pro Glu 
    130                 135                 140                 


Pro Gln Gln Glu Pro Val Leu Ile Thr Met Ala Thr Val Val Leu Thr 
145                 150                 155                 160 


Val Leu Thr His Thr Pro Ala Pro Arg Val Arg Leu Gly Gln Asp Ala 
                165                 170                 175     


Leu Leu Asp Leu Ser Phe Ala Tyr Met Pro Pro Thr Ser Glu Ala Ala 
            180                 185                 190         


Ser Ser Leu Ala Pro Gly Pro Pro Pro Phe Gly Leu Glu Trp Arg Arg 
        195                 200                 205             


Gln His Leu Gly Lys Gly His Leu Leu Leu Ala Ala Thr Pro Gly Leu 
    210                 215                 220                 


Asn Gly Gln Met Pro Ala Ala Gln Glu Gly Ala Val Ala Phe Ala Ala 
225                 230                 235                 240 


Trp Asp Asp Asp Glu Pro Trp Gly Pro Trp Thr Gly Asn Gly Thr Phe 
                245                 250                 255     


Trp Leu Pro Thr Val Gln Pro Phe Gln Glu Gly Thr Tyr Leu Ala Thr 
            260                 265                 270         


Ile His Leu Pro Tyr Leu Gln Gly Gln Val Thr Leu Glu Leu Ala Val 
        275                 280                 285             


Tyr Ser Glu Leu Gly Asp Arg Gly Leu Gln Gly 
    290                 295                 


<210>  1729
<211>  1410
<212>  DNA
<213>  Homosapiens

<400>  1729
ctggagagga tctacccggg tccctgcctg gccagtgggg aaacaccggt cccccaggca     60

ccttcaccta accagagcgg ggatttccac cgcccctcat gccgcccttt ggaggaaagt    120

gaaagtgaaa ggaggaagag gaggcttcat ggctgaggag gtcgcagcgc catgaagtcc    180

ctgtctctgc tcctcgctgt ggctttgggc ctggcgaccg ccgtctcagc aggacccgcg    240

gtgatcgagt gttggttcgt ggaggatgcg agcggaaagg gcctggccaa gagacccggt    300

gcactgctgt tgcgccaggg accgggggaa ccgccgcccc ggccggacct cgaccctgag    360

ctctatctca gtgtacacga ccccgcgggc gccctccagg ctgccttcag gcggtatccc    420

cggggcgccc ccgcaccaca ctgcgagatg agccgcttcg tgcctctccc cgcctctgcg    480

aaatgggcca gcggcctgac ccccgcgcag aactgcccgc gggccctgga tggggcttgg    540

ctgatggtca gcatatccag cccagtcctc agcctctcca gcctcttgcg accacagcca    600

gagcctcagc aggagcctgt tctcatcacc atggcaacag tggtactgac tgtcctcacc    660

cacacccctg cccctcgagt gagactggga caagatgctc tgctggactt gagctttgcc    720

tacatgcccc ccacctccga ggccgcctca tctctggctc cgggtccccc tccctttggg    780

ctagagtggc gacgccagca cctgggtaag ggacatctgc tcctggctgc aactcctggg    840

ctgaatggcc agatgccagc agcccaagaa ggggccgtgg catttgctgc ttgggatgat    900

gatgagccat ggggcccatg gaccggaaat gggaccttct ggctgcctac agttcaaccc    960

tttcaggagg gcacctatct ggccaccata cacctgccat acctgcaagg acaggtcacc   1020

ctggagcttg ctgtgtacaa accccccaaa gtgtccctga tgccagcaac ccttgcacgg   1080

gccgccccag gggaggcacc cccggaattg ctctgccttg tgtcccactt ctacccttct   1140

gggggcctgg aggtggagtg ggaactccgg ggtggcccag ggggccgctc tcagaaggcc   1200

gaggggcaga ggtggctctc ggccctgcgc caccattccg atggctctgt cagcctctct   1260

gggcacttgc agccgccccc agtcaccact gagcagcatg gggcacgcta tgcctgtcga   1320

attcaccatc ccagcctgcc tgcctcgggg cgcagcgctg aggtcaccct ggaggtagca   1380

ggtaagagct gggagctctg cggaatctga                                    1410


<210>  1730
<211>  412
<212>  PRT
<213>  Homosapiens

<400>  1730

Met Lys Ser Leu Ser Leu Leu Leu Ala Val Ala Leu Gly Leu Ala Thr 
1               5                   10                  15      


Ala Val Ser Ala Gly Pro Ala Val Ile Glu Cys Trp Phe Val Glu Asp 
            20                  25                  30          


Ala Ser Gly Lys Gly Leu Ala Lys Arg Pro Gly Ala Leu Leu Leu Arg 
        35                  40                  45              


Gln Gly Pro Gly Glu Pro Pro Pro Arg Pro Asp Leu Asp Pro Glu Leu 
    50                  55                  60                  


Tyr Leu Ser Val His Asp Pro Ala Gly Ala Leu Gln Ala Ala Phe Arg 
65                  70                  75                  80  


Arg Tyr Pro Arg Gly Ala Pro Ala Pro His Cys Glu Met Ser Arg Phe 
                85                  90                  95      


Val Pro Leu Pro Ala Ser Ala Lys Trp Ala Ser Gly Leu Thr Pro Ala 
            100                 105                 110         


Gln Asn Cys Pro Arg Ala Leu Asp Gly Ala Trp Leu Met Val Ser Ile 
        115                 120                 125             


Ser Ser Pro Val Leu Ser Leu Ser Ser Leu Leu Arg Pro Gln Pro Glu 
    130                 135                 140                 


Pro Gln Gln Glu Pro Val Leu Ile Thr Met Ala Thr Val Val Leu Thr 
145                 150                 155                 160 


Val Leu Thr His Thr Pro Ala Pro Arg Val Arg Leu Gly Gln Asp Ala 
                165                 170                 175     


Leu Leu Asp Leu Ser Phe Ala Tyr Met Pro Pro Thr Ser Glu Ala Ala 
            180                 185                 190         


Ser Ser Leu Ala Pro Gly Pro Pro Pro Phe Gly Leu Glu Trp Arg Arg 
        195                 200                 205             


Gln His Leu Gly Lys Gly His Leu Leu Leu Ala Ala Thr Pro Gly Leu 
    210                 215                 220                 


Asn Gly Gln Met Pro Ala Ala Gln Glu Gly Ala Val Ala Phe Ala Ala 
225                 230                 235                 240 


Trp Asp Asp Asp Glu Pro Trp Gly Pro Trp Thr Gly Asn Gly Thr Phe 
                245                 250                 255     


Trp Leu Pro Thr Val Gln Pro Phe Gln Glu Gly Thr Tyr Leu Ala Thr 
            260                 265                 270         


Ile His Leu Pro Tyr Leu Gln Gly Gln Val Thr Leu Glu Leu Ala Val 
        275                 280                 285             


Tyr Lys Pro Pro Lys Val Ser Leu Met Pro Ala Thr Leu Ala Arg Ala 
    290                 295                 300                 


Ala Pro Gly Glu Ala Pro Pro Glu Leu Leu Cys Leu Val Ser His Phe 
305                 310                 315                 320 


Tyr Pro Ser Gly Gly Leu Glu Val Glu Trp Glu Leu Arg Gly Gly Pro 
                325                 330                 335     


Gly Gly Arg Ser Gln Lys Ala Glu Gly Gln Arg Trp Leu Ser Ala Leu 
            340                 345                 350         


Arg His His Ser Asp Gly Ser Val Ser Leu Ser Gly His Leu Gln Pro 
        355                 360                 365             


Pro Pro Val Thr Thr Glu Gln His Gly Ala Arg Tyr Ala Cys Arg Ile 
    370                 375                 380                 


His His Pro Ser Leu Pro Ala Ser Gly Arg Ser Ala Glu Val Thr Leu 
385                 390                 395                 400 


Glu Val Ala Gly Lys Ser Trp Glu Leu Cys Gly Ile 
                405                 410         


<210>  1731
<211>  2647
<212>  DNA
<213>  Homosapiens

<400>  1731
ggggcccagg ttgctgctct ggccgccgag tgaggggcgg ggggggcccg ggggcgcgcg     60

gcccgagacc cccccggccg ccctcctcct ttctttgttc ctgtggctgg gggggtatcc    120

cctccctcca caacatggag ccatctcctc tgtctcccag tggggcagca cttcccctgc    180

cgctgtcgct ggctccgccc ccactacccc tgccagcagc tgcagtggta catgtgtcct    240

tccctgaggt gaccagtgcc ctcttggagt ccctcaatca gcagcgtctg cagggccagc    300

tctgcgatgt atctatcaga gtgcagggcc gggagttccg ggctcatcgg gctgtcctgg    360

ctgcctcctc cccttacttc catgatcagg tcctactcaa aggcatgacc tccatctcgc    420

tgcccagtgt catggaccca ggcgcctttg agactgtcct agcctccgct tacactggcc    480

gcctcagcat ggctgctgct gacattgtca acttccttac agtggggtct gtgctccaaa    540

tgtggcacat tgtggacaag tgcactgaac tactccgaga aggccgggcc tcagctacca    600

ccaccatcac tactgctgca gccacctctg tcactgtccc tggtgctggg gtgccatccg    660

ggagtggggg cactgtggcc cctgctacca tgggctctgc gcgctcccat gcctccagcc    720

gggccagtga gaatcaatct cccagcagca gcaactactt cagccccagg gagtccactg    780

atttctcatc ttcctcccaa gaggcatttg cagcttctgc agtgggcagt ggggagcgtc    840

gaggaggtgg ccctgtattc ccagcccctg tcgttggcag tggaggggcc acatctggaa    900

agctgctgct ggaggcagat gagctgtgcg atgatggtgg ggatgggagg ggggcagtgg    960

ttcctggggc tgggctccgg agacccacct acacaccccc tagcatcatg ccacagaaac   1020

actgggtata cgtgaagcga ggtggtaatt gcccagcgcc agcacccctg gttccccaag   1080

acccagatct ggaggaggaa gaggaggagg aagatctggt gttgacctgt gaggatgatg   1140

aagatgaaga actagggggt agctccaggg ttccagtggg gggagggcct gaggctaccc   1200

tcagcataag tgatgtccgt accctgagtg agcccccaga caagggggag gagcaggtca   1260

acttctgtga gtcctccaat gactttggcc catatgaggg tgggggtcct gtggcaggtc   1320

ttgatgactc aggggggcca actccctctt cctatgcccc ctcccaccct cctcgaccgc   1380

tccttccctt ggacatgcag ggcaaccaga tcctggtctt cccgtcgtcg tcttcatcct   1440

catcctcaca ggctcctggc caaccaccag ggaaccaagc agaacacggg gcagtgaccg   1500

tggggggcac gtcggtgggg agcctgggtg tgccgggtag cgttggtggg gtccctggag   1560

ggactggcag tggggacggg aataagatct ttctgtgcca ttgtgggaag gccttctccc   1620

acaagagcat gcgggaccgg cacgtgaaca tgcacctcaa tctgcggccg tttgactgcc   1680

ccgtgtgcaa caaaaagttc aagatgaagc accatctgac tgagcacatg aagacgcaca   1740

caggtctcaa gccctacgag tgcggagtct gcgccaagaa gttcatgtgg cgagacagct   1800

tcatgcgcca ccgaggacac tgtgagcgcc ggcaccgcct gggcggggtc ggggccgtac   1860

ctgggcctgg gactcccacg gggccatcct tgccgtccaa gagagagtct cccggagtgg   1920

gcgggggcag cggcgacgaa gcgagtgcgg ccacgccccc gtccagcaga cgtgtctggt   1980

ccccacccag agtccacaag gtggagatgg gcttcggtgg aggtggagga gcaaactgaa   2040

ggggcaggct actggggtgg ggtagctttc gggaaaggga ataaggagca cgatgcaagg   2100

gcgctgtggc ccccgggtga tctcccacca cacttactgt cttcctttat ctctgtggac   2160

ttgtatatat tctggaaggg gaaccacagt ttcaccatca cccgcccatt ctactactca   2220

acccctcccc cccaaggtat ttccagaact aaacccttcc tttccctctg atgggtacac   2280

tgaagcccct gctccacaga gtagattgca catggaggga gggagagggg gcgtgttgaa   2340

catcctgcag tcacagggtc aggggtcagg tggttgtagt ctgtgcctga agtctgtgtt   2400

tgtgttgtcg tggagacaag gcctttgagc cccacccttg tcctagaacc taccccctct   2460

caaggatgcg ctctttattt ctaccctgtc tctccccgcc acccccgact tcccgtggaa   2520

attcccaact cggttctcat ggaggagtgg gtggagacaa ggagggagta agtcgtagga   2580

gtacaaggtt tttatttttt ttaacagtga ttaaaatatt tattggtcat ttaaaaaaaa   2640

aaaaaaa                                                             2647


<210>  1732
<211>  634
<212>  PRT
<213>  Homosapiens

<400>  1732

Met Glu Pro Ser Pro Leu Ser Pro Ser Gly Ala Ala Leu Pro Leu Pro 
1               5                   10                  15      


Leu Ser Leu Ala Pro Pro Pro Leu Pro Leu Pro Ala Ala Ala Val Val 
            20                  25                  30          


His Val Ser Phe Pro Glu Val Thr Ser Ala Leu Leu Glu Ser Leu Asn 
        35                  40                  45              


Gln Gln Arg Leu Gln Gly Gln Leu Cys Asp Val Ser Ile Arg Val Gln 
    50                  55                  60                  


Gly Arg Glu Phe Arg Ala His Arg Ala Val Leu Ala Ala Ser Ser Pro 
65                  70                  75                  80  


Tyr Phe His Asp Gln Val Leu Leu Lys Gly Met Thr Ser Ile Ser Leu 
                85                  90                  95      


Pro Ser Val Met Asp Pro Gly Ala Phe Glu Thr Val Leu Ala Ser Ala 
            100                 105                 110         


Tyr Thr Gly Arg Leu Ser Met Ala Ala Ala Asp Ile Val Asn Phe Leu 
        115                 120                 125             


Thr Val Gly Ser Val Leu Gln Met Trp His Ile Val Asp Lys Cys Thr 
    130                 135                 140                 


Glu Leu Leu Arg Glu Gly Arg Ala Ser Ala Thr Thr Thr Ile Thr Thr 
145                 150                 155                 160 


Ala Ala Ala Thr Ser Val Thr Val Pro Gly Ala Gly Val Pro Ser Gly 
                165                 170                 175     


Ser Gly Gly Thr Val Ala Pro Ala Thr Met Gly Ser Ala Arg Ser His 
            180                 185                 190         


Ala Ser Ser Arg Ala Ser Glu Asn Gln Ser Pro Ser Ser Ser Asn Tyr 
        195                 200                 205             


Phe Ser Pro Arg Glu Ser Thr Asp Phe Ser Ser Ser Ser Gln Glu Ala 
    210                 215                 220                 


Phe Ala Ala Ser Ala Val Gly Ser Gly Glu Arg Arg Gly Gly Gly Pro 
225                 230                 235                 240 


Val Phe Pro Ala Pro Val Val Gly Ser Gly Gly Ala Thr Ser Gly Lys 
                245                 250                 255     


Leu Leu Leu Glu Ala Asp Glu Leu Cys Asp Asp Gly Gly Asp Gly Arg 
            260                 265                 270         


Gly Ala Val Val Pro Gly Ala Gly Leu Arg Arg Pro Thr Tyr Thr Pro 
        275                 280                 285             


Pro Ser Ile Met Pro Gln Lys His Trp Val Tyr Val Lys Arg Gly Gly 
    290                 295                 300                 


Asn Cys Pro Ala Pro Ala Pro Leu Val Pro Gln Asp Pro Asp Leu Glu 
305                 310                 315                 320 


Glu Glu Glu Glu Glu Glu Asp Leu Val Leu Thr Cys Glu Asp Asp Glu 
                325                 330                 335     


Asp Glu Glu Leu Gly Gly Ser Ser Arg Val Pro Val Gly Gly Gly Pro 
            340                 345                 350         


Glu Ala Thr Leu Ser Ile Ser Asp Val Arg Thr Leu Ser Glu Pro Pro 
        355                 360                 365             


Asp Lys Gly Glu Glu Gln Val Asn Phe Cys Glu Ser Ser Asn Asp Phe 
    370                 375                 380                 


Gly Pro Tyr Glu Gly Gly Gly Pro Val Ala Gly Leu Asp Asp Ser Gly 
385                 390                 395                 400 


Gly Pro Thr Pro Ser Ser Tyr Ala Pro Ser His Pro Pro Arg Pro Leu 
                405                 410                 415     


Leu Pro Leu Asp Met Gln Gly Asn Gln Ile Leu Val Phe Pro Ser Ser 
            420                 425                 430         


Ser Ser Ser Ser Ser Ser Gln Ala Pro Gly Gln Pro Pro Gly Asn Gln 
        435                 440                 445             


Ala Glu His Gly Ala Val Thr Val Gly Gly Thr Ser Val Gly Ser Leu 
    450                 455                 460                 


Gly Val Pro Gly Ser Val Gly Gly Val Pro Gly Gly Thr Gly Ser Gly 
465                 470                 475                 480 


Asp Gly Asn Lys Ile Phe Leu Cys His Cys Gly Lys Ala Phe Ser His 
                485                 490                 495     


Lys Ser Met Arg Asp Arg His Val Asn Met His Leu Asn Leu Arg Pro 
            500                 505                 510         


Phe Asp Cys Pro Val Cys Asn Lys Lys Phe Lys Met Lys His His Leu 
        515                 520                 525             


Thr Glu His Met Lys Thr His Thr Gly Leu Lys Pro Tyr Glu Cys Gly 
    530                 535                 540                 


Val Cys Ala Lys Lys Phe Met Trp Arg Asp Ser Phe Met Arg His Arg 
545                 550                 555                 560 


Gly His Cys Glu Arg Arg His Arg Leu Gly Gly Val Gly Ala Val Pro 
                565                 570                 575     


Gly Pro Gly Thr Pro Thr Gly Pro Ser Leu Pro Ser Lys Arg Glu Ser 
            580                 585                 590         


Pro Gly Val Gly Gly Gly Ser Gly Asp Glu Ala Ser Ala Ala Thr Pro 
        595                 600                 605             


Pro Ser Ser Arg Arg Val Trp Ser Pro Pro Arg Val His Lys Val Glu 
    610                 615                 620                 


Met Gly Phe Gly Gly Gly Gly Gly Ala Asn 
625                 630                 


<210>  1733
<211>  2477
<212>  DNA
<213>  Homosapiens

<400>  1733
ggcggaggga accatgcgag gttctgagaa ttgcggcgag ggtcgcctcg agagacggtt     60

tctgaggaat tctgaaatcc ccaccacttc ctccctccgg gggatttgat cccctatggc    120

caccgctaac agcatcatcg tgctggatga tgatgacgaa gatgaagcag ctgctcagcc    180

agggccctcc cacccactcc ccaatgcggc ctcacctggg gcagaagccc ctagctcctc    240

tgagcctcat ggggccagag gaagcagtag ttcgggcggc aagaaatgct acaagctgga    300

gaatgagaag ctgttcgaag agttccttga actttgtaag atgcagacag cagaccaccc    360

tgaggtggtc ccattcctct ataaccggca gcaacgtgcc cactctctgt ttttggcctc    420

ggcggagttc tgcaacatcc tctctagggt cctgtctcgg gcccggagcc ggccagccaa    480

gctctatgtc tacatcaatg agctctgcac tgttctcaag gcccactcag ccaaaaagaa    540

gctgaacttg gcccctgccg ccaccacctc caatgagccc tctgggaata accctcccac    600

acacctctcc ttggacccca caaatgctga aaacactgcc tctcagtctc caaggacccg    660

tggttcccgg cggcagatcc agcgtttgga gcagctgctg gcgctctatg tggcagagat    720

ccggcggctg caggaaaagg agttggatct ctcagaattg gatgacccag actccgcata    780

cctgcaggag gcacggttga agcgtaagct gatccgcctc tttgggcgac tatgtgagct    840

gaaagactgc tcttcactga ccggccgtgt catagagcag cgcatcccct accgtggcac    900

ccgctaccca gaggttaaca ggcgcattga gcggctcatc aacaagccag ggcctgatac    960

cttccctgac tatggggatg tgcttcgggc tgtagagaag gcagctgccc gacacagcct   1020

tggcctcccc cgacagcagc tccagctcat ggctcaggat gccttccgag atgtgggcat   1080

caggttacag gagcgacgtc acctcgatct catctacaac tttggctgcc acctcacaga   1140

tgactatagg ccaggcgttg accctgcact atcagatcct gtgttggccc ggcgccttcg   1200

ggaaaaccgg agtttggcca tgagtcggct ggatgaggtc atctccaaat atgcaatgtt   1260

gcaagacaaa agtgaggagg gcgagagaaa aaagagaaga gctcggctcc aaggcacctc   1320

ttcccactct gcagacaccc ccgaagcctc cttggattct ggtgagggcc ctagtggaat   1380

ggcatcccag gggtgccctt ctgcctccag agctgagaca gatgacgaag acgatgagga   1440

gagtgatgag gaagaggagg aggaggagga agaagaagag gaggaggcca cagattctga   1500

agaggaggag gatctggaac agatgcagga gggtcaggag gatgatgaag aggaggacga   1560

agaggaagaa gcagcagcag gtaaagatgg agacaagagc cccatgtcct cactacagat   1620

ctccaatgaa aagaacctgg aacctggcaa acagatcagc agatcttcag gggagcagca   1680

aaacaaagga cgcatagtgt caccatcgtt actgtcagaa gaacccctgg ccccctccag   1740

catagatgct gaaagcaatg gagaacagcc tgaggagctg accctggagg aagaaagccc   1800

tgtgtctcag ctctttgagc tagagattga agctttgccc ctggataccc cttcctctgt   1860

ggagacggac atttcctctt ccaggaagca atcagaggag cccttcacca ctgtcttaga   1920

gaatggagca ggcatggtct cttctacttc cttcaatgga ggcgtctctc ctcacaactg   1980

gggagattct ggtcccccct gcaaaaaatc tcggaaggag aagaagcaaa caggatcagg   2040

gccattagga aacagctatg tggaaaggca aaggtcagtg catgagaaga atgggaaaaa   2100

gatatgtacc ctgcccagcc caccttcccc cttggcttcc ttggccccag ttgctgattc   2160

ctccacgagg gtggactctc ccagccatgg cctggtgacc agctccctct gcatcccttc   2220

tccagcccgg ctgtcccaaa ccccccattc acagcctcct cggcctggta cttgcaagac   2280

aagtgtggcc acacaatgcg atccagaaga gatcatcgtg ctctcagact ctgattagct   2340

gcctcccctt ctccctgcct ccagaatgtt ctgggataac atttggagga aggtgggaag   2400

cagatgactg aggaagggat ggactaagct aatccccttt tggtggtgtt tctttaaaaa   2460

aaaaaaaaaa aaaaaaa                                                  2477


<210>  1734
<211>  740
<212>  PRT
<213>  Homosapiens

<400>  1734

Met Ala Thr Ala Asn Ser Ile Ile Val Leu Asp Asp Asp Asp Glu Asp 
1               5                   10                  15      


Glu Ala Ala Ala Gln Pro Gly Pro Ser His Pro Leu Pro Asn Ala Ala 
            20                  25                  30          


Ser Pro Gly Ala Glu Ala Pro Ser Ser Ser Glu Pro His Gly Ala Arg 
        35                  40                  45              


Gly Ser Ser Ser Ser Gly Gly Lys Lys Cys Tyr Lys Leu Glu Asn Glu 
    50                  55                  60                  


Lys Leu Phe Glu Glu Phe Leu Glu Leu Cys Lys Met Gln Thr Ala Asp 
65                  70                  75                  80  


His Pro Glu Val Val Pro Phe Leu Tyr Asn Arg Gln Gln Arg Ala His 
                85                  90                  95      


Ser Leu Phe Leu Ala Ser Ala Glu Phe Cys Asn Ile Leu Ser Arg Val 
            100                 105                 110         


Leu Ser Arg Ala Arg Ser Arg Pro Ala Lys Leu Tyr Val Tyr Ile Asn 
        115                 120                 125             


Glu Leu Cys Thr Val Leu Lys Ala His Ser Ala Lys Lys Lys Leu Asn 
    130                 135                 140                 


Leu Ala Pro Ala Ala Thr Thr Ser Asn Glu Pro Ser Gly Asn Asn Pro 
145                 150                 155                 160 


Pro Thr His Leu Ser Leu Asp Pro Thr Asn Ala Glu Asn Thr Ala Ser 
                165                 170                 175     


Gln Ser Pro Arg Thr Arg Gly Ser Arg Arg Gln Ile Gln Arg Leu Glu 
            180                 185                 190         


Gln Leu Leu Ala Leu Tyr Val Ala Glu Ile Arg Arg Leu Gln Glu Lys 
        195                 200                 205             


Glu Leu Asp Leu Ser Glu Leu Asp Asp Pro Asp Ser Ala Tyr Leu Gln 
    210                 215                 220                 


Glu Ala Arg Leu Lys Arg Lys Leu Ile Arg Leu Phe Gly Arg Leu Cys 
225                 230                 235                 240 


Glu Leu Lys Asp Cys Ser Ser Leu Thr Gly Arg Val Ile Glu Gln Arg 
                245                 250                 255     


Ile Pro Tyr Arg Gly Thr Arg Tyr Pro Glu Val Asn Arg Arg Ile Glu 
            260                 265                 270         


Arg Leu Ile Asn Lys Pro Gly Pro Asp Thr Phe Pro Asp Tyr Gly Asp 
        275                 280                 285             


Val Leu Arg Ala Val Glu Lys Ala Ala Ala Arg His Ser Leu Gly Leu 
    290                 295                 300                 


Pro Arg Gln Gln Leu Gln Leu Met Ala Gln Asp Ala Phe Arg Asp Val 
305                 310                 315                 320 


Gly Ile Arg Leu Gln Glu Arg Arg His Leu Asp Leu Ile Tyr Asn Phe 
                325                 330                 335     


Gly Cys His Leu Thr Asp Asp Tyr Arg Pro Gly Val Asp Pro Ala Leu 
            340                 345                 350         


Ser Asp Pro Val Leu Ala Arg Arg Leu Arg Glu Asn Arg Ser Leu Ala 
        355                 360                 365             


Met Ser Arg Leu Asp Glu Val Ile Ser Lys Tyr Ala Met Leu Gln Asp 
    370                 375                 380                 


Lys Ser Glu Glu Gly Glu Arg Lys Lys Arg Arg Ala Arg Leu Gln Gly 
385                 390                 395                 400 


Thr Ser Ser His Ser Ala Asp Thr Pro Glu Ala Ser Leu Asp Ser Gly 
                405                 410                 415     


Glu Gly Pro Ser Gly Met Ala Ser Gln Gly Cys Pro Ser Ala Ser Arg 
            420                 425                 430         


Ala Glu Thr Asp Asp Glu Asp Asp Glu Glu Ser Asp Glu Glu Glu Glu 
        435                 440                 445             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Thr Asp Ser Glu Glu Glu 
    450                 455                 460                 


Glu Asp Leu Glu Gln Met Gln Glu Gly Gln Glu Asp Asp Glu Glu Glu 
465                 470                 475                 480 


Asp Glu Glu Glu Glu Ala Ala Ala Gly Lys Asp Gly Asp Lys Ser Pro 
                485                 490                 495     


Met Ser Ser Leu Gln Ile Ser Asn Glu Lys Asn Leu Glu Pro Gly Lys 
            500                 505                 510         


Gln Ile Ser Arg Ser Ser Gly Glu Gln Gln Asn Lys Gly Arg Ile Val 
        515                 520                 525             


Ser Pro Ser Leu Leu Ser Glu Glu Pro Leu Ala Pro Ser Ser Ile Asp 
    530                 535                 540                 


Ala Glu Ser Asn Gly Glu Gln Pro Glu Glu Leu Thr Leu Glu Glu Glu 
545                 550                 555                 560 


Ser Pro Val Ser Gln Leu Phe Glu Leu Glu Ile Glu Ala Leu Pro Leu 
                565                 570                 575     


Asp Thr Pro Ser Ser Val Glu Thr Asp Ile Ser Ser Ser Arg Lys Gln 
            580                 585                 590         


Ser Glu Glu Pro Phe Thr Thr Val Leu Glu Asn Gly Ala Gly Met Val 
        595                 600                 605             


Ser Ser Thr Ser Phe Asn Gly Gly Val Ser Pro His Asn Trp Gly Asp 
    610                 615                 620                 


Ser Gly Pro Pro Cys Lys Lys Ser Arg Lys Glu Lys Lys Gln Thr Gly 
625                 630                 635                 640 


Ser Gly Pro Leu Gly Asn Ser Tyr Val Glu Arg Gln Arg Ser Val His 
                645                 650                 655     


Glu Lys Asn Gly Lys Lys Ile Cys Thr Leu Pro Ser Pro Pro Ser Pro 
            660                 665                 670         


Leu Ala Ser Leu Ala Pro Val Ala Asp Ser Ser Thr Arg Val Asp Ser 
        675                 680                 685             


Pro Ser His Gly Leu Val Thr Ser Ser Leu Cys Ile Pro Ser Pro Ala 
    690                 695                 700                 


Arg Leu Ser Gln Thr Pro His Ser Gln Pro Pro Arg Pro Gly Thr Cys 
705                 710                 715                 720 


Lys Thr Ser Val Ala Thr Gln Cys Asp Pro Glu Glu Ile Ile Val Leu 
                725                 730                 735     


Ser Asp Ser Asp 
            740 


<210>  1735
<211>  570
<212>  DNA
<213>  Homosapiens

<400>  1735
atgcatctgg cagcccactt ctggtgtttg gcgctggaat taaacaacca ccatgtggag     60

caaaaaggca agaccaagac caccaaaaag ctccctcagc gcacaacatc caacgtgttt    120

gccatgtttg accagtcaca gattcaggag ttcaaagagg ccttcaacat gattgatcag    180

aacagagatg gtttcatcaa caaagaagat ttgcatgata tgcttgtttc cctagggaag    240

aatcccaccg atgcatacct tgatgccata atgaatgagg caccagggcc catcgatttc    300

accatgttcc tcaccatatt tggtgagaag ttaaatggca cagatcctga agatgtcatt    360

ggaaatgctt ttgcttgctt tgatgaagaa gcaacaggca ttattcagga agattacctg    420

agagagctgc tgataaccat gtgggatcgg tttacggatg aggaagtgga tgagctgtac    480

agagaagcgc ctattaacaa aaaggggaat ttcaattaca tcgagttcac atgcatcctg    540

aaacatggag caaaagacaa agacgactga                                     570


<210>  1736
<211>  189
<212>  PRT
<213>  Homosapiens

<400>  1736

Met His Leu Ala Ala His Phe Trp Cys Leu Ala Leu Glu Leu Asn Asn 
1               5                   10                  15      


His His Val Glu Gln Lys Gly Lys Thr Lys Thr Thr Lys Lys Leu Pro 
            20                  25                  30          


Gln Arg Thr Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile 
        35                  40                  45              


Gln Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly 
    50                  55                  60                  


Phe Ile Asn Lys Glu Asp Leu His Asp Met Leu Val Ser Leu Gly Lys 
65                  70                  75                  80  


Asn Pro Thr Asp Ala Tyr Leu Asp Ala Ile Met Asn Glu Ala Pro Gly 
                85                  90                  95      


Pro Ile Asp Phe Thr Met Phe Leu Thr Ile Phe Gly Glu Lys Leu Asn 
            100                 105                 110         


Gly Thr Asp Pro Glu Asp Val Ile Gly Asn Ala Phe Ala Cys Phe Asp 
        115                 120                 125             


Glu Glu Ala Thr Gly Ile Ile Gln Glu Asp Tyr Leu Arg Glu Leu Leu 
    130                 135                 140                 


Ile Thr Met Trp Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Leu Tyr 
145                 150                 155                 160 


Arg Glu Ala Pro Ile Asn Lys Lys Gly Asn Phe Asn Tyr Ile Glu Phe 
                165                 170                 175     


Thr Cys Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
            180                 185                 


<210>  1737
<211>  2391
<212>  DNA
<213>  Homosapiens

<400>  1737
tcaaaagtgg cgggtgtggc gcggggctgg tagcggccgg agccgtgcga gttctctacc     60

ctgcttcgcg agcgggcgag agaacgcgag tcccaggatc cccggcaccc agttctcttc    120

cactgcattc ccccggcgcg tgtgggaccg aggtggacat ggatccgcag aggtcccccc    180

tattggaagt aaaggggaac atagaactga agagacctct gattaaggcc ccttcccagc    240

tgcctctctc aggaagcaga ctcaagagga ggcctgacca gatggaagat ggcctggagc    300

ctgagaagaa acggacaaga ggcctgggtg caacgaccaa aattaccaca tcccacccaa    360

gagttccatc cctcactaca gtgccacaga cacaaggcca gaccacagct caaaaagttt    420

ccaagaagac aggaccccgg tgttccacag ctattgccac agggttgaag aaccagaagc    480

cagttcctgc tgttcctgtc cagaagtctg gcacatcagg tgttcctccc atggcaggag    540

ggaagaaacc cagcaaacgt ccagcctggg acttaaaggg tcagttatgt gacctaaatg    600

cagaactaaa acggtgccgt gagaggactc aaacgttgga ccaagagaac cagcagcttc    660

aggaccagct cagagatgcc cagcagcagg tcaaggccct ggggacagag cgcacaacac    720

tggaggggca tttagccaag gtacaggccc aggctgagca gggccaacag gagctgaaga    780

acttgcgtgc ttgtgtcctg gagctggaag agcggctgag cacgcaggag ggcttggtgc    840

aagagcttca gaaaaaacag gtggaattgc aggaagaacg gaggggactg atgtcccaac    900

tagaggagaa ggagaggagg ctgcagacat cagaagcagc cctgtcaagc agccaagcag    960

aggtggcatc tctgcggcag gagactgtgg cccaggcagc cttactgact gagcgggaag   1020

aacgtcttca tgggctagaa atggagcgcc ggcgactgca caaccagctg caggaactca   1080

agggcaacat ccgtgtattc tgccgggtcc gccctgtcct gccgggggag cccactccac   1140

cccctggcct cctcctgttt ccctctggcc ctggtgggcc ctctgatcct ccaacccgcc   1200

ttagcctctc ccggtctgac gagcggcgtg ggaccctgag tggggcacca gctcccccac   1260

ctcgccatga tttttccttt gaccgggtat tcccaccagg aagtggacag gatgaagtgt   1320

ttgaagagat tgccatgctt gtccagtcag ccctggatgg ctatccagta tgcatctttg   1380

cctatggcca gacaggcagt ggcaagacct tcacaatgga gggtgggcct gggggagacc   1440

cccagttgga ggggctgatc cctcgggccc tgcggcacct cttctctgtg gctcaggagc   1500

tgagtggtca gggctggacc tacagctttg tagcaagcta cgtagagatc tacaatgaga   1560

ctgtccggga cctgctggcc actggaaccc ggaagggtca agggggcgag tgtgagattc   1620

gccgtgcagg gccagggagt gaggagctca ctgtcaccaa tgctcgatat gtccctgtct   1680

cctgtgagaa agaagtggac gccctgcttc atctggcccg ccagaatcgg gctgtggccc   1740

gcacagccca gaatgaacgg tcatcacgca gccacagtgt attccagcta cagatttctg   1800

gggagcactc cagccgaggc ctgcagtgtg gggcccccct cagtcttgtg gacctggccg   1860

ggagtgagcg acttgacccc ggcttagccc tcggccccgg ggagcgggaa cgccttcggg   1920

aaacacaggc cattaacagc agcctgtcca cgctggggct ggttatcatg gccctgagca   1980

acaaggagtc ccacgtgcct taccggaaca gcaaactgac ctacctgctg cagaactctc   2040

tgggtggtag tgctaagatg ctcatgtttg tgaacatttc tccactggaa gagaacgtct   2100

ccgagtccct caactctcta cgctttgcct ccaaggtgaa ccagtgtgtt attggtactg   2160

ctcaggccaa caggaagtga agacggatcc agatctgtgt gtgtgtgtgt gtgtgtgtgt   2220

gtgtgtgtgt gtgtgtgtgt gtgtgtgtcc ctatgtctat gtatcgggtg aggggtggga   2280

gggttgctgg agggtgcttt attgggtgga gggcaccatg tcccagggct atcaaataaa   2340

gaatagtttg gttttttttt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa a            2391


<210>  1738
<211>  673
<212>  PRT
<213>  Homosapiens

<400>  1738

Met Asp Pro Gln Arg Ser Pro Leu Leu Glu Val Lys Gly Asn Ile Glu 
1               5                   10                  15      


Leu Lys Arg Pro Leu Ile Lys Ala Pro Ser Gln Leu Pro Leu Ser Gly 
            20                  25                  30          


Ser Arg Leu Lys Arg Arg Pro Asp Gln Met Glu Asp Gly Leu Glu Pro 
        35                  40                  45              


Glu Lys Lys Arg Thr Arg Gly Leu Gly Ala Thr Thr Lys Ile Thr Thr 
    50                  55                  60                  


Ser His Pro Arg Val Pro Ser Leu Thr Thr Val Pro Gln Thr Gln Gly 
65                  70                  75                  80  


Gln Thr Thr Ala Gln Lys Val Ser Lys Lys Thr Gly Pro Arg Cys Ser 
                85                  90                  95      


Thr Ala Ile Ala Thr Gly Leu Lys Asn Gln Lys Pro Val Pro Ala Val 
            100                 105                 110         


Pro Val Gln Lys Ser Gly Thr Ser Gly Val Pro Pro Met Ala Gly Gly 
        115                 120                 125             


Lys Lys Pro Ser Lys Arg Pro Ala Trp Asp Leu Lys Gly Gln Leu Cys 
    130                 135                 140                 


Asp Leu Asn Ala Glu Leu Lys Arg Cys Arg Glu Arg Thr Gln Thr Leu 
145                 150                 155                 160 


Asp Gln Glu Asn Gln Gln Leu Gln Asp Gln Leu Arg Asp Ala Gln Gln 
                165                 170                 175     


Gln Val Lys Ala Leu Gly Thr Glu Arg Thr Thr Leu Glu Gly His Leu 
            180                 185                 190         


Ala Lys Val Gln Ala Gln Ala Glu Gln Gly Gln Gln Glu Leu Lys Asn 
        195                 200                 205             


Leu Arg Ala Cys Val Leu Glu Leu Glu Glu Arg Leu Ser Thr Gln Glu 
    210                 215                 220                 


Gly Leu Val Gln Glu Leu Gln Lys Lys Gln Val Glu Leu Gln Glu Glu 
225                 230                 235                 240 


Arg Arg Gly Leu Met Ser Gln Leu Glu Glu Lys Glu Arg Arg Leu Gln 
                245                 250                 255     


Thr Ser Glu Ala Ala Leu Ser Ser Ser Gln Ala Glu Val Ala Ser Leu 
            260                 265                 270         


Arg Gln Glu Thr Val Ala Gln Ala Ala Leu Leu Thr Glu Arg Glu Glu 
        275                 280                 285             


Arg Leu His Gly Leu Glu Met Glu Arg Arg Arg Leu His Asn Gln Leu 
    290                 295                 300                 


Gln Glu Leu Lys Gly Asn Ile Arg Val Phe Cys Arg Val Arg Pro Val 
305                 310                 315                 320 


Leu Pro Gly Glu Pro Thr Pro Pro Pro Gly Leu Leu Leu Phe Pro Ser 
                325                 330                 335     


Gly Pro Gly Gly Pro Ser Asp Pro Pro Thr Arg Leu Ser Leu Ser Arg 
            340                 345                 350         


Ser Asp Glu Arg Arg Gly Thr Leu Ser Gly Ala Pro Ala Pro Pro Pro 
        355                 360                 365             


Arg His Asp Phe Ser Phe Asp Arg Val Phe Pro Pro Gly Ser Gly Gln 
    370                 375                 380                 


Asp Glu Val Phe Glu Glu Ile Ala Met Leu Val Gln Ser Ala Leu Asp 
385                 390                 395                 400 


Gly Tyr Pro Val Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys 
                405                 410                 415     


Thr Phe Thr Met Glu Gly Gly Pro Gly Gly Asp Pro Gln Leu Glu Gly 
            420                 425                 430         


Leu Ile Pro Arg Ala Leu Arg His Leu Phe Ser Val Ala Gln Glu Leu 
        435                 440                 445             


Ser Gly Gln Gly Trp Thr Tyr Ser Phe Val Ala Ser Tyr Val Glu Ile 
    450                 455                 460                 


Tyr Asn Glu Thr Val Arg Asp Leu Leu Ala Thr Gly Thr Arg Lys Gly 
465                 470                 475                 480 


Gln Gly Gly Glu Cys Glu Ile Arg Arg Ala Gly Pro Gly Ser Glu Glu 
                485                 490                 495     


Leu Thr Val Thr Asn Ala Arg Tyr Val Pro Val Ser Cys Glu Lys Glu 
            500                 505                 510         


Val Asp Ala Leu Leu His Leu Ala Arg Gln Asn Arg Ala Val Ala Arg 
        515                 520                 525             


Thr Ala Gln Asn Glu Arg Ser Ser Arg Ser His Ser Val Phe Gln Leu 
    530                 535                 540                 


Gln Ile Ser Gly Glu His Ser Ser Arg Gly Leu Gln Cys Gly Ala Pro 
545                 550                 555                 560 


Leu Ser Leu Val Asp Leu Ala Gly Ser Glu Arg Leu Asp Pro Gly Leu 
                565                 570                 575     


Ala Leu Gly Pro Gly Glu Arg Glu Arg Leu Arg Glu Thr Gln Ala Ile 
            580                 585                 590         


Asn Ser Ser Leu Ser Thr Leu Gly Leu Val Ile Met Ala Leu Ser Asn 
        595                 600                 605             


Lys Glu Ser His Val Pro Tyr Arg Asn Ser Lys Leu Thr Tyr Leu Leu 
    610                 615                 620                 


Gln Asn Ser Leu Gly Gly Ser Ala Lys Met Leu Met Phe Val Asn Ile 
625                 630                 635                 640 


Ser Pro Leu Glu Glu Asn Val Ser Glu Ser Leu Asn Ser Leu Arg Phe 
                645                 650                 655     


Ala Ser Lys Val Asn Gln Cys Val Ile Gly Thr Ala Gln Ala Asn Arg 
            660                 665                 670         


Lys 
    


<210>  1739
<211>  2008
<212>  DNA
<213>  Homosapiens

<400>  1739
gcccctgccc ggctcccggc ggccccagct gtcaccggcc cccccaggat gcaatggcgc     60

agcccccccg gctgagccgc tctggtgcct cctcactttg ggacccagct tctcctgctc    120

ccacctctgg ccccaggcct cggctttggg agggtcaaga tgtgctggcc agatggactg    180

atgggctgct atacttgggt accatcaaaa aggtggacag tgctagggag gtgtgtctgg    240

tccagtttga ggatgattcg cagtttctgg ttctatggaa agacattagc cctgctgccc    300

tccctggaga ggaactcctc tgttgtgtct gtcgctctga gactgtggtc cctgggaacc    360

ggctggtcag ctgtgagaag tgtcgccatg cttatcacca ggactgccat gttcccaggg    420

ctccagcccc tggagaggga gagggcacat cctgggtatg ccgccagtgt gtctttgcga    480

tcgccaccaa gaggggaggt gccctgaaga agggccccta tgcccgggcc atgctgggta    540

tgaagctttc tctgccatat ggactgaagg ggctggactg ggatgctgga catctgagca    600

accgacagca gagttactgt tactgtggtg gccctgggga gtggaacctg aaaatgctgc    660

agtgccggag ctgcctgcag tggttccatg aggcctgcac ccagtgtctg agcaagcccc    720

tcctctatgg ggacaggttc tatgaatttg aatgctgtgt gtgtcgcggg ggccctgaga    780

aagtccggag actacagctt cgctgggtgg atgtggccca tcttgtcctg tatcacctca    840

gtgtttgctg taagaagaaa tactttgatt ttgatcgtga gatcctcccc ttcacttctg    900

agaattggga cagtttgctc ctgggggagc tttcagacac ccccaaagga gaacgttctt    960

ccaagctcct ctctgctctt aacagccaca aggaccgttt catttcaggg agagagatta   1020

agaagaggaa atgtttgttt ggtctccatg ctcggatgcc tccccctgtg gagcccccta   1080

ctggagatgg agcactcacc agggcagggc cctgggggag gggtctcacg tcccctgggg   1140

aagcgccgga ggccggagcc agagcccctg aggaggaggc agaaggggaa agtggaggag   1200

ctggggccac cctcagcagt gcgcaatcag cccgagcccc aggagcagag ggagcgggct   1260

catctgcaga gggcactgca gcagccccat ccggatgttt gcttccttcc acccttctgc   1320

cagcaccgca gggacctctg gggacagtgg acccccagac aggtcacccc tggaacttca   1380

cattggtttc cccacagaca tccctaaaag tgccccccac tcgatgactg cctcatcttc   1440

ctcagtttca tccccatccc caggtcttcc tagacgctca gcaccccctt ctcccctgtg   1500

ccgtagtttg tctcctggga ctgggggagg agtccgaggt ggggttggtt acctgtcccg   1560

aggggaccct gtccgggtcc ttgctcggag agtacggcct gatggctctg tgcagtacct   1620

ggttgagtgg ggaggagggg gcatcttctg aacagcctgc ctctgcccag ctccccattc   1680

acacacaccg gcactttcat accctgacct ctgacctcac ctacagctgg gatgtacctg   1740

gagagatagg gggtagttct ccctactgcc caggctggaa tccaagagtg gggagtgggg   1800

aagaggccct cttctctacc ctccttcatg attcctgacc cctcccatcc ttcccatttc   1860

ctttgatgtt attttgttac agctttttaa atatttttta aaattattta acccctgggg   1920

gcagagactg aggagggagg atgataaggg atcccggact ctgtatgatt gaaataaaga   1980

gaaataaaca aaaaaaaaaa aaaaaaaa                                      2008


<210>  1740
<211>  457
<212>  PRT
<213>  Homosapiens

<400>  1740

Met Ala Gln Pro Pro Arg Leu Ser Arg Ser Gly Ala Ser Ser Leu Trp 
1               5                   10                  15      


Asp Pro Ala Ser Pro Ala Pro Thr Ser Gly Pro Arg Pro Arg Leu Trp 
            20                  25                  30          


Glu Gly Gln Asp Val Leu Ala Arg Trp Thr Asp Gly Leu Leu Tyr Leu 
        35                  40                  45              


Gly Thr Ile Lys Lys Val Asp Ser Ala Arg Glu Val Cys Leu Val Gln 
    50                  55                  60                  


Phe Glu Asp Asp Ser Gln Phe Leu Val Leu Trp Lys Asp Ile Ser Pro 
65                  70                  75                  80  


Ala Ala Leu Pro Gly Glu Glu Leu Leu Cys Cys Val Cys Arg Ser Glu 
                85                  90                  95      


Thr Val Val Pro Gly Asn Arg Leu Val Ser Cys Glu Lys Cys Arg His 
            100                 105                 110         


Ala Tyr His Gln Asp Cys His Val Pro Arg Ala Pro Ala Pro Gly Glu 
        115                 120                 125             


Gly Glu Gly Thr Ser Trp Val Cys Arg Gln Cys Val Phe Ala Ile Ala 
    130                 135                 140                 


Thr Lys Arg Gly Gly Ala Leu Lys Lys Gly Pro Tyr Ala Arg Ala Met 
145                 150                 155                 160 


Leu Gly Met Lys Leu Ser Leu Pro Tyr Gly Leu Lys Gly Leu Asp Trp 
                165                 170                 175     


Asp Ala Gly His Leu Ser Asn Arg Gln Gln Ser Tyr Cys Tyr Cys Gly 
            180                 185                 190         


Gly Pro Gly Glu Trp Asn Leu Lys Met Leu Gln Cys Arg Ser Cys Leu 
        195                 200                 205             


Gln Trp Phe His Glu Ala Cys Thr Gln Cys Leu Ser Lys Pro Leu Leu 
    210                 215                 220                 


Tyr Gly Asp Arg Phe Tyr Glu Phe Glu Cys Cys Val Cys Arg Gly Gly 
225                 230                 235                 240 


Pro Glu Lys Val Arg Arg Leu Gln Leu Arg Trp Val Asp Val Ala His 
                245                 250                 255     


Leu Val Leu Tyr His Leu Ser Val Cys Cys Lys Lys Lys Tyr Phe Asp 
            260                 265                 270         


Phe Asp Arg Glu Ile Leu Pro Phe Thr Ser Glu Asn Trp Asp Ser Leu 
        275                 280                 285             


Leu Leu Gly Glu Leu Ser Asp Thr Pro Lys Gly Glu Arg Ser Ser Lys 
    290                 295                 300                 


Leu Leu Ser Ala Leu Asn Ser His Lys Asp Arg Phe Ile Ser Gly Arg 
305                 310                 315                 320 


Glu Ile Lys Lys Arg Lys Cys Leu Phe Gly Leu His Ala Arg Met Pro 
                325                 330                 335     


Pro Pro Val Glu Pro Pro Thr Gly Asp Gly Ala Leu Thr Arg Ala Gly 
            340                 345                 350         


Pro Trp Gly Arg Gly Leu Thr Ser Pro Gly Glu Ala Pro Glu Ala Gly 
        355                 360                 365             


Ala Arg Ala Pro Glu Glu Glu Ala Glu Gly Glu Ser Gly Gly Ala Gly 
    370                 375                 380                 


Ala Thr Leu Ser Ser Ala Gln Ser Ala Arg Ala Pro Gly Ala Glu Gly 
385                 390                 395                 400 


Ala Gly Ser Ser Ala Glu Gly Thr Ala Ala Ala Pro Ser Gly Cys Leu 
                405                 410                 415     


Leu Pro Ser Thr Leu Leu Pro Ala Pro Gln Gly Pro Leu Gly Thr Val 
            420                 425                 430         


Asp Pro Gln Thr Gly His Pro Trp Asn Phe Thr Leu Val Ser Pro Gln 
        435                 440                 445             


Thr Ser Leu Lys Val Pro Pro Thr Arg 
    450                 455         


<210>  1741
<211>  2260
<212>  DNA
<213>  Homosapiens

<400>  1741
ctcctcctgc cgctgccgct gctttggctg ctgcgtcata cgccccagag ccgccgggac     60

ggaggggctg ggcctgggga ccccccggcc tccgcctgca cgccccccca cgcccggacg    120

tgccctctcc gcgcggggga ctcgcctagg tctcctacgt ctgcccctgc ccggctcccg    180

gcggccccag ctgtcaccgg cccccccagg atgcaatggc gcagcccccc cggctgagcc    240

gctctggtgc ctcctcactt tgggacccag cttctcctgc tcccacctct ggccccaggc    300

ctcggctttg ggagggtcaa gatgtgctgg ccagatggac tgatgggctg ctatacttgg    360

gtaccatcaa aaaggtggac agtgctaggg aggtgtgtct ggtccagttt gaggatgatt    420

cgcagtttct ggttctatgg aaagacatta gccctgctgc cctccctgga gaggaactcc    480

tctgttgtgt ctgtcgctct gagactgtgg tccctgggaa ccggctggtc agctgtgaga    540

agtgtcgcca tgcttatcac caggactgcc atgttcccag ggctccagcc cctggagagg    600

gagagggcac atcctgggta tgccgccagt gtgtctttgc gatcgccacc aagaggggag    660

gtgccctgaa gaagggcccc tatgcccggg ccatgctggg tatgaagctt tctctgccat    720

atggactgaa ggggctggac tgggatgctg gacatctgag caaccgacag cagagttact    780

gttactgtgg tggccctggg gagtggaacc tgaaaatgct gcagtgccgg agctgcctgc    840

agtggttcca tgaggcctgc acccagtgtc tgagcaagcc cctcctctat ggggacaggt    900

tctatgaatt tgaatgctgt gtgtgtcgcg ggggccctga gaaagtccgg agactacagc    960

ttcgctgggt ggatgtggcc catcttgtcc tgtatcacct cagtgtttgc tgtaagaaga   1020

aatactttga ttttgatcgt gagatcctcc ccttcacttc tgagaattgg gacagtttgc   1080

tcctggggga gctttcagac acccccaaag gagaacgttc ttccaagctc ctctctgctc   1140

ttaacagcca caaggaccgt ttcatttcag ggagagagat taagaagagg aaatgtttgt   1200

ttggtctcca tgctcggatg cctccccctg tggagccccc tactggagat ggagcactca   1260

ccagcttccc ttcagggcag ggccctgggg gaggggtctc acgtcccctg gggaagcgcc   1320

ggaggccgga gccagagccc ctgaggagga ggcagaaggg gaaagtggag gagctggggc   1380

caccctcagc agtgcgcaat cagcccgagc cccaggagca gagggagcgg gctcatctgc   1440

agagggcact gcaggcctca gtgtctccac catcccccag ccctaaccag agttaccagg   1500

gcagcagcgg ctacaacttc cggcccacag atgcccgctg cctgcccagc agccccatcc   1560

ggatgtttgc ttccttccac ccttctgcca gcaccgcagg gacctctggg gacagtggac   1620

ccccagacag gtcacccctg gaacttcaca ttggtttccc cacagacatc cctaaaagtg   1680

ccccccactc gatgactgcc tcatcttcct cagtttcatc cccatcccca ggtcttccta   1740

gacgctcagc acccccttct cccctgtgcc gtagtttgtc tcctgggact gggggaggag   1800

tccgaggtgg ggttggttac ctgtcccgag gggaccctgt ccgggtcctt gctcggagag   1860

tacggcctga tggctctgtg cagtacctgg ttgagtgggg aggagggggc atcttctgaa   1920

cagcctgcct ctgcccagct ccccattcac acacaccggc actttcatac cctgacctct   1980

gacctcacct acagctggga tgtacctgga gagatagggg gtagttctcc ctactgccca   2040

ggctggaatc caagagtggg gagtggggaa gaggccctct tctctaccct ccttcatgat   2100

tcctgacccc tcccatcctt cccatttcct ttgatgttat tttgttacag ctttttaaat   2160

attttttaaa attatttaac ccctgggggc agagactgag gagggaggat gataagggat   2220

cccggactct gtatgattga aataaagaga aataaacaaa                         2260


<210>  1742
<211>  567
<212>  PRT
<213>  Homosapiens

<400>  1742

Met Ala Gln Pro Pro Arg Leu Ser Arg Ser Gly Ala Ser Ser Leu Trp 
1               5                   10                  15      


Asp Pro Ala Ser Pro Ala Pro Thr Ser Gly Pro Arg Pro Arg Leu Trp 
            20                  25                  30          


Glu Gly Gln Asp Val Leu Ala Arg Trp Thr Asp Gly Leu Leu Tyr Leu 
        35                  40                  45              


Gly Thr Ile Lys Lys Val Asp Ser Ala Arg Glu Val Cys Leu Val Gln 
    50                  55                  60                  


Phe Glu Asp Asp Ser Gln Phe Leu Val Leu Trp Lys Asp Ile Ser Pro 
65                  70                  75                  80  


Ala Ala Leu Pro Gly Glu Glu Leu Leu Cys Cys Val Cys Arg Ser Glu 
                85                  90                  95      


Thr Val Val Pro Gly Asn Arg Leu Val Ser Cys Glu Lys Cys Arg His 
            100                 105                 110         


Ala Tyr His Gln Asp Cys His Val Pro Arg Ala Pro Ala Pro Gly Glu 
        115                 120                 125             


Gly Glu Gly Thr Ser Trp Val Cys Arg Gln Cys Val Phe Ala Ile Ala 
    130                 135                 140                 


Thr Lys Arg Gly Gly Ala Leu Lys Lys Gly Pro Tyr Ala Arg Ala Met 
145                 150                 155                 160 


Leu Gly Met Lys Leu Ser Leu Pro Tyr Gly Leu Lys Gly Leu Asp Trp 
                165                 170                 175     


Asp Ala Gly His Leu Ser Asn Arg Gln Gln Ser Tyr Cys Tyr Cys Gly 
            180                 185                 190         


Gly Pro Gly Glu Trp Asn Leu Lys Met Leu Gln Cys Arg Ser Cys Leu 
        195                 200                 205             


Gln Trp Phe His Glu Ala Cys Thr Gln Cys Leu Ser Lys Pro Leu Leu 
    210                 215                 220                 


Tyr Gly Asp Arg Phe Tyr Glu Phe Glu Cys Cys Val Cys Arg Gly Gly 
225                 230                 235                 240 


Pro Glu Lys Val Arg Arg Leu Gln Leu Arg Trp Val Asp Val Ala His 
                245                 250                 255     


Leu Val Leu Tyr His Leu Ser Val Cys Cys Lys Lys Lys Tyr Phe Asp 
            260                 265                 270         


Phe Asp Arg Glu Ile Leu Pro Phe Thr Ser Glu Asn Trp Asp Ser Leu 
        275                 280                 285             


Leu Leu Gly Glu Leu Ser Asp Thr Pro Lys Gly Glu Arg Ser Ser Lys 
    290                 295                 300                 


Leu Leu Ser Ala Leu Asn Ser His Lys Asp Arg Phe Ile Ser Gly Arg 
305                 310                 315                 320 


Glu Ile Lys Lys Arg Lys Cys Leu Phe Gly Leu His Ala Arg Met Pro 
                325                 330                 335     


Pro Pro Val Glu Pro Pro Thr Gly Asp Gly Ala Leu Thr Ser Phe Pro 
            340                 345                 350         


Ser Gly Gln Gly Pro Gly Gly Gly Val Ser Arg Pro Leu Gly Lys Arg 
        355                 360                 365             


Arg Arg Pro Glu Pro Glu Pro Leu Arg Arg Arg Gln Lys Gly Lys Val 
    370                 375                 380                 


Glu Glu Leu Gly Pro Pro Ser Ala Val Arg Asn Gln Pro Glu Pro Gln 
385                 390                 395                 400 


Glu Gln Arg Glu Arg Ala His Leu Gln Arg Ala Leu Gln Ala Ser Val 
                405                 410                 415     


Ser Pro Pro Ser Pro Ser Pro Asn Gln Ser Tyr Gln Gly Ser Ser Gly 
            420                 425                 430         


Tyr Asn Phe Arg Pro Thr Asp Ala Arg Cys Leu Pro Ser Ser Pro Ile 
        435                 440                 445             


Arg Met Phe Ala Ser Phe His Pro Ser Ala Ser Thr Ala Gly Thr Ser 
    450                 455                 460                 


Gly Asp Ser Gly Pro Pro Asp Arg Ser Pro Leu Glu Leu His Ile Gly 
465                 470                 475                 480 


Phe Pro Thr Asp Ile Pro Lys Ser Ala Pro His Ser Met Thr Ala Ser 
                485                 490                 495     


Ser Ser Ser Val Ser Ser Pro Ser Pro Gly Leu Pro Arg Arg Ser Ala 
            500                 505                 510         


Pro Pro Ser Pro Leu Cys Arg Ser Leu Ser Pro Gly Thr Gly Gly Gly 
        515                 520                 525             


Val Arg Gly Gly Val Gly Tyr Leu Ser Arg Gly Asp Pro Val Arg Val 
    530                 535                 540                 


Leu Ala Arg Arg Val Arg Pro Asp Gly Ser Val Gln Tyr Leu Val Glu 
545                 550                 555                 560 


Trp Gly Gly Gly Gly Ile Phe 
                565         


<210>  1743
<211>  823
<212>  DNA
<213>  Homosapiens

<400>  1743
acggaaacgg gcgtgccatt tccgcgcacg tctgcagatg cggtagtcga ttggtcaagt     60

ctcccatggc tcctccttca tcaggaggtg ggcaaaccgc gccatgatag ggtcgggatt    120

ggctggctct ggaggcgcag gtggtccttc ttctactgtc acatggtgcg cgctgttttc    180

taatcacgtg gctgccaccc aggcctctct gctcctgtct tttgtttgga tgccggcgct    240

gctgcctgtg gcctcccgcc ttttgttgct accccgagtc ttgctgacca tggcctctgg    300

aagccctccg acccagccct cgccggcctc ggattccggc tctggctacg ttccgggctc    360

ggtctctgca gcctttgtta cttgccccaa cgagaaggtc gccaaggaga tcgccagggc    420

cgtggtggag aagcgcctag cagcctgcgt caacctcatc cctcagatta catccatcta    480

tgagtggaaa gggaagatcg aggaagacag tgaggtgctg atgatgatta aaacccaaag    540

ttccttggtc ccagctttga cagattttgt tcgttctgtg cacccttacg aagtggccga    600

ggtaattgca ttgcctgtgg aacaggggaa ctttccgtac ctgcagtggg tgcgccaggt    660

cacagagtca gtttctgact ctatcacagt cctgccatga tgagccctgt tcctgctcat    720

catgaagatc cccgcgatac ttcaacgcct tctgacttcc aggtgatgac tgggccccca    780

ataaatcccg tctttgggtc tctctgccaa aaaaaaaaaa aaa                      823


<210>  1744
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  1744

Met Ile Gly Ser Gly Leu Ala Gly Ser Gly Gly Ala Gly Gly Pro Ser 
1               5                   10                  15      


Ser Thr Val Thr Trp Cys Ala Leu Phe Ser Asn His Val Ala Ala Thr 
            20                  25                  30          


Gln Ala Ser Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro 
        35                  40                  45              


Val Ala Ser Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala 
    50                  55                  60                  


Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser 
65                  70                  75                  80  


Gly Tyr Val Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn 
                85                  90                  95      


Glu Lys Val Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu 
            100                 105                 110         


Ala Ala Cys Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp 
        115                 120                 125             


Lys Gly Lys Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr 
    130                 135                 140                 


Gln Ser Ser Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His 
145                 150                 155                 160 


Pro Tyr Glu Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn 
                165                 170                 175     


Phe Pro Tyr Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp 
            180                 185                 190         


Ser Ile Thr Val Leu Pro 
        195             


<210>  1745
<211>  1072
<212>  DNA
<213>  Homosapiens

<400>  1745
acggaaacgg gcgtgccatt tccgcgcacg tctgcagatg cggtagtcga ttggtcaagt     60

ctcccatggc tcctccttca tcaggaggtg ggcaaaccgc gccatgatag ggtcgggatt    120

ggctggctct ggaggcgcag gtggtccttc ttctactgtc acatggtgcg cgctgttttc    180

taatcacgtg gctgccaccc aggtaagaag aggccgctct tcctggggtt gtttctccgt    240

gtgacgtgtg gcctttgaga tcaactctcc tgtaccagcg taggccgcat gagtgggggg    300

cgggctcccg cggtcctgct cggcggagtg gggcattctt cgggggtgca tcagagggag    360

ggcagagcct gaggatctaa gcgaaggctt ccccgggtgt aatttcctgg gctgtttgtg    420

aggagagatc gaattcgcct cctgctctca ggcctctctg ctcctgtctt ttgtttggat    480

gccggcgctg ctgcctgtgg cctcccgcct tttgttgcta ccccgagtct tgctgaccat    540

ggcctctgga agccctccga cccagccctc gccggcctcg gattccggct ctggctacgt    600

tccgggctcg gtctctgcag cctttgttac ttgccccaac gagaaggtcg ccaaggagat    660

cgccagggcc gtggtggaga agcgcctagc agcctgcgtc aacctcatcc ctcagattac    720

atccatctat gagtggaaag ggaagatcga ggaagacagt gaggtgctga tgatgattaa    780

aacccaaagt tccttggtcc cagctttgac agattttgtt cgttctgtgc acccttacga    840

agtggccgag gtaattgcat tgcctgtgga acaggggaac tttccgtacc tgcagtgggt    900

gcgccaggtc acagagtcag tttctgactc tatcacagtc ctgccatgat gagccctgtt    960

cctgctcatc atgaagatcc ccgcgatact tcaacgcctt ctgacttcca ggtgatgact   1020

gggcccccaa taaatcccgt ctttgggtct ctctgccaaa aaaaaaaaaa aa           1072


<210>  1746
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  1746

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  1747
<211>  1041
<212>  DNA
<213>  Homosapiens

<400>  1747
acggaaacgg gcgtgccatt tccgcgcacg tctgcagatg cggtagtcga ttggtcaagt     60

ctcccatggc tcctccttca tcaggaggtg ggcaaaccgc gccatgatag ggtcgggatt    120

ggctggctct ggaggcgcag gtggtccttc ttctactgtc acatggtgcg cgctgttttc    180

taatcacgtg gctgccaccc aggtaagaag aggccgctct tcctggggtt gtttctccgt    240

gtgacgtgtg gcctttgaga tcaactctcc tgtaccagcg taggccgcat gagtgggggg    300

cgggctcccg cggtcctgct cggcggagtg gtgagtgacc ggccccgccc cgccccttcc    360

ggtcctcgaa gcctcgaccg ctacccgcac cctaaatccc agaggttggc cccctgaggt    420

gcctctctgc tcctgtcttt tgtttggatg ccggcgctgc tgcctgtggc ctcccgcctt    480

ttgttgctac cccgagtctt gctgaccatg gcctctggaa gccctccgac ccagccctcg    540

ccggcctcgg attccggctc tggctacgtt ccgggctcgg tctctgcagc ctttgttact    600

tgccccaacg agaaggtcgc caaggagatc gccagggccg tggtggagaa gcgcctagca    660

gcctgcgtca acctcatccc tcagattaca tccatctatg agtggaaagg gaagatcgag    720

gaagacagtg aggtgctgat gatgattaaa acccaaagtt ccttggtccc agctttgaca    780

gattttgttc gttctgtgca cccttacgaa gtggccgagg taattgcatt gcctgtggaa    840

caggggaact ttccgtacct gcagtgggtg cgccaggtca cagagtcagt ttctgactct    900

atcacagtcc tgccatgatg agccctgttc ctgctcatca tgaagatccc cgcgatactt    960

caacgccttc tgacttccag gtgatgactg ggcccccaat aaatcccgtc tttgggtctc   1020

tctgccaaaa aaaaaaaaaa a                                             1041


<210>  1748
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  1748

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  1749
<211>  951
<212>  DNA
<213>  Homosapiens

<400>  1749
acggaaacgg gcgtgccatt tccgcgcacg tctgcagatg cggtagtcga ttggtcaagt     60

ctcccatggc tcctccttca tcaggaggtg ggcaaaccgc gccatgatag ggtcgggatt    120

ggctggctct ggaggcgcag gtggtccttc ttctactgtc acatggtgcg cgctgttttc    180

taatcacgtg gctgccaccc aggtaagaag aggccgctct tcctggggtt gtttctccgt    240

gtgacgtgtg gcctttgaga tcaactctcc tgtaccagcg taggccgcat gagtgggggg    300

cgggctcccg cggtcctgct cggcggagtg gcctctctgc tcctgtcttt tgtttggatg    360

ccggcgctgc tgcctgtggc ctcccgcctt ttgttgctac cccgagtctt gctgaccatg    420

gcctctggaa gccctccgac ccagccctcg ccggcctcgg attccggctc tggctacgtt    480

ccgggctcgg tctctgcagc ctttgttact tgccccaacg agaaggtcgc caaggagatc    540

gccagggccg tggtggagaa gcgcctagca gcctgcgtca acctcatccc tcagattaca    600

tccatctatg agtggaaagg gaagatcgag gaagacagtg aggtgctgat gatgattaaa    660

acccaaagtt ccttggtccc agctttgaca gattttgttc gttctgtgca cccttacgaa    720

gtggccgagg taattgcatt gcctgtggaa caggggaact ttccgtacct gcagtgggtg    780

cgccaggtca cagagtcagt ttctgactct atcacagtcc tgccatgatg agccctgttc    840

ctgctcatca tgaagatccc cgcgatactt caacgccttc tgacttccag gtgatgactg    900

ggcccccaat aaatcccgtc tttgggtctc tctgccaaaa aaaaaaaaaa a             951


<210>  1750
<211>  179
<212>  PRT
<213>  Homosapiens

<400>  1750

Met Ser Gly Gly Arg Ala Pro Ala Val Leu Leu Gly Gly Val Ala Ser 
1               5                   10                  15      


Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro Val Ala Ser 
            20                  25                  30          


Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala Ser Gly Ser 
        35                  40                  45              


Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser Gly Tyr Val 
    50                  55                  60                  


Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn Glu Lys Val 
65                  70                  75                  80  


Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu Ala Ala Cys 
                85                  90                  95      


Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp Lys Gly Lys 
            100                 105                 110         


Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr Gln Ser Ser 
        115                 120                 125             


Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His Pro Tyr Glu 
    130                 135                 140                 


Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn Phe Pro Tyr 
145                 150                 155                 160 


Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp Ser Ile Thr 
                165                 170                 175     


Val Leu Pro 
            


<210>  1751
<211>  1214
<212>  DNA
<213>  Homosapiens

<400>  1751
acggaaacgg gcgtgccatt tccgcgcacg tctgcagatg cggtagtcga ttggtcaagt     60

ctcccatggc tcctccttca tcaggaggtg ggcaaaccgc gccatgatag ggtcgggatt    120

ggctggctct ggaggcgcag gtggtccttc ttctactgtc acatggtgcg cgctgttttc    180

taatcacgtg gctgccaccc aggtaagaag aggccgctct tcctggggtt gtttctccgt    240

gtgacgtgtg gcctttgaga tcaactctcc tgtaccagcg taggccgcat gagtgggggg    300

cgggctcccg cggtcctgct cggcggagtg gtgagtgacc ggccccgccc cgccccttcc    360

ggtcctcgaa gcctcgaccg ctacccgcac cctaaatccc agaggttggc cccctgaggt    420

gtgagtgaaa tgagcttttg ctttattttc caagtttctc tctcaccttc aggggcattc    480

ttcgggggtg catcagaggg agggcagagc ctgaggatct aagcgaaggc ttccccgggt    540

gtaatttcct gggctgtttg tgaggagaga tcgaattcgc ctcctgctct caggcctctc    600

tgctcctgtc ttttgtttgg atgccggcgc tgctgcctgt ggcctcccgc cttttgttgc    660

taccccgagt cttgctgacc atggcctctg gaagccctcc gacccagccc tcgccggcct    720

cggattccgg ctctggctac gttccgggct cggtctctgc agcctttgtt acttgcccca    780

acgagaaggt cgccaaggag atcgccaggg ccgtggtgga gaagcgccta gcagcctgcg    840

tcaacctcat ccctcagatt acatccatct atgagtggaa agggaagatc gaggaagaca    900

gtgaggtgct gatgatgatt aaaacccaaa gttccttggt cccagctttg acagattttg    960

ttcgttctgt gcacccttac gaagtggccg aggtaattgc attgcctgtg gaacagggga   1020

actttccgta cctgcagtgg gtgcgccagg tcacagagtc agtttctgac tctatcacag   1080

tcctgccatg atgagccctg ttcctgctca tcatgaagat ccccgcgata cttcaacgcc   1140

ttctgacttc caggtgatga ctgggccccc aataaatccc gtctttgggt ctctctgcca   1200

aaaaaaaaaa aaaa                                                     1214


<210>  1752
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  1752

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  1753
<211>  2730
<212>  DNA
<213>  Homosapiens

<400>  1753
ttccggtctg ggacggagct gtagcggcac tgtaactgcg agggcagcgc cgcgtgtgta     60

acggcggggg cgtgtcggcg ggaaggacaa tcgggccggg actcgcggtg tccgggtgac    120

cgcggcttcc cgggagcaga cctctgtggg cactgtgagg cggaacggag cggcggggca    180

ggagctgttc tgggcagcct tcatcccgcg tggagtctac ccccaagccc ttctcctctt    240

cccaattctt gtcaccttcg aggaggccat ggaaacccca acacctttgc cgcctgtacc    300

cgcctccccg acctgcaacc cagccccacg gacaatccag atcgagttcc cacagcatag    360

ctcgtctctg ctggaatctc tgaaccgcca caggctagag ggaaagttct gtgatgtgtc    420

cctcctggtg cagggccggg aacttagggc tcataaagca gtgttagctg ctgcctctcc    480

ttacttccat gacaagctgc ttctggggga tgcgcctcgt ctcactctac cgagtgtcat    540

tgaagccgat gccttcgagg ggctgctcca gctcatttat tcagggcgtc tccgcctgcc    600

actggatgct cttcctgctc atctccttgt ggccagtggc cttcaaatgt ggcaggtagt    660

agatcagtgc tcagaaattc ttagagaatt agaaacttca ggtggtggaa tttcagcccg    720

tggaggaaac tcctaccatg cccttctttc cactacatcc tctacaggag gctggtgcat    780

tcgctcttcg cctttccaga ccccagtaca gtcctctgct tctactgaaa gccctgcttc    840

cactgagagc cctgtgggag gggagggaag tgaactggga gaagtgctgc aaattcaggt    900

ggaagaagaa gaggaggagg aggaagatga tgatgatgag gaccaggggt cagccacact    960

ctctcagact cctcagcccc agagagtatc aggggttttt ccccgtcctc atggacccca   1020

cccactgccc atgactgcta ctccccgaaa gcttccagag ggtgagagtg caccacttga   1080

gcttcctgcc cctcctgcac tgccccccaa aatcttctac attaagcagg aacccttcga   1140

gcctaaggag gagatatcag gaagcggaac tcagcctgga ggagcaaagg aggaaaccaa   1200

agtgttttct ggaggggaca ctgaagggaa tggggagcta gggttcttgt tgccttcagg   1260

gccagggcca acatctgggg gagggggtcc atcctggaaa ccagtggatc ttcatgggaa   1320

tgaaatcctg tcagggggtg gaggacctgg gggagcaggc caggccgtgc atgggcctgt   1380

gaagctaggg gggacacccc ctgcagatgg aaaacgcttt ggttgcctgt gtgggaagcg   1440

gtttgcagtg aagccaaagc gtgaccggca catcatgctg accttcagcc ttcggccttt   1500

tggctgtggc atctgcaaca agcgcttcaa gctgaagcac catctgacag agcacatgaa   1560

gacccatgct ggagccctgc atgcctgtcc ccactgtggc cgtcggttcc gagtccatgc   1620

ctgttttctc cgccaccggg acctatgcaa gggccagggc tgggccactg cccactggac   1680

ttacaagtga ctgctgaggc tatacactag cttctagaac aagataacca ctgctgctga   1740

tggatacttt tccctcactg ccatggcaca ccagtcatgg atcttgtaat catgccaaga   1800

gaatagatac attatggacc tcttgttctt agatatgggc ctctcagcct ggcagatgtg   1860

gaaactcaaa tttctcgtcc cactccaggt tttggctagc caaccctgca ggaaagtggt   1920

ttataggcca ttcatactta agttgatcac ttgcccatgg tggacatttt tgtggtggtg   1980

atgtccatta aggaaaccag attttcaatt atttagtgag agaagagtta gagcaaaaga   2040

cagtggtaaa tgttttattc cgtctccatg aggaattgaa ggagttggtc tccacctaga   2100

gatacatttg atttacagct taagtaattc agaggctaag ctctaagctt ttttctctca   2160

ttgctggaat gatttaagca gaagtccttt tgtgtacttt taaaattgta tctttccagg   2220

agcccctcag attgtacctt gctttctcac caatagacac cttcccgaca cttttttaat   2280

gttgtagctg agcactttaa caagttgagc attccatgtt tcattcttag aaccttcttt   2340

aatagagggt cttccctcaa cagcctgtgc ctctggtcta cctttgacca ccactgataa   2400

ctaatatatt ggtcacaatg actggaatgt gactagtgat ctcaggagat ggcactgtcc   2460

taaagtgctg tcagggtggc accactgctc tctgaacaac ttaccttggt cagagggact   2520

caggtttggg acagcacaag ctgaaggctg gagagtaact tgcatagtag gaccatacct   2580

cttcctttcc catcccaccc acatatgata gacagcccct ctgttgagat atggagggga   2640

cagatactgg aatcgggggt gggacttgca gttacttaaa attttttaat aaactgtgcc   2700

ctgaaaccta aaaaaaaaaa aaaaaaaaaa                                    2730


<210>  1754
<211>  473
<212>  PRT
<213>  Homosapiens

<400>  1754

Met Glu Thr Pro Thr Pro Leu Pro Pro Val Pro Ala Ser Pro Thr Cys 
1               5                   10                  15      


Asn Pro Ala Pro Arg Thr Ile Gln Ile Glu Phe Pro Gln His Ser Ser 
            20                  25                  30          


Ser Leu Leu Glu Ser Leu Asn Arg His Arg Leu Glu Gly Lys Phe Cys 
        35                  40                  45              


Asp Val Ser Leu Leu Val Gln Gly Arg Glu Leu Arg Ala His Lys Ala 
    50                  55                  60                  


Val Leu Ala Ala Ala Ser Pro Tyr Phe His Asp Lys Leu Leu Leu Gly 
65                  70                  75                  80  


Asp Ala Pro Arg Leu Thr Leu Pro Ser Val Ile Glu Ala Asp Ala Phe 
                85                  90                  95      


Glu Gly Leu Leu Gln Leu Ile Tyr Ser Gly Arg Leu Arg Leu Pro Leu 
            100                 105                 110         


Asp Ala Leu Pro Ala His Leu Leu Val Ala Ser Gly Leu Gln Met Trp 
        115                 120                 125             


Gln Val Val Asp Gln Cys Ser Glu Ile Leu Arg Glu Leu Glu Thr Ser 
    130                 135                 140                 


Gly Gly Gly Ile Ser Ala Arg Gly Gly Asn Ser Tyr His Ala Leu Leu 
145                 150                 155                 160 


Ser Thr Thr Ser Ser Thr Gly Gly Trp Cys Ile Arg Ser Ser Pro Phe 
                165                 170                 175     


Gln Thr Pro Val Gln Ser Ser Ala Ser Thr Glu Ser Pro Ala Ser Thr 
            180                 185                 190         


Glu Ser Pro Val Gly Gly Glu Gly Ser Glu Leu Gly Glu Val Leu Gln 
        195                 200                 205             


Ile Gln Val Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Asp Glu 
    210                 215                 220                 


Asp Gln Gly Ser Ala Thr Leu Ser Gln Thr Pro Gln Pro Gln Arg Val 
225                 230                 235                 240 


Ser Gly Val Phe Pro Arg Pro His Gly Pro His Pro Leu Pro Met Thr 
                245                 250                 255     


Ala Thr Pro Arg Lys Leu Pro Glu Gly Glu Ser Ala Pro Leu Glu Leu 
            260                 265                 270         


Pro Ala Pro Pro Ala Leu Pro Pro Lys Ile Phe Tyr Ile Lys Gln Glu 
        275                 280                 285             


Pro Phe Glu Pro Lys Glu Glu Ile Ser Gly Ser Gly Thr Gln Pro Gly 
    290                 295                 300                 


Gly Ala Lys Glu Glu Thr Lys Val Phe Ser Gly Gly Asp Thr Glu Gly 
305                 310                 315                 320 


Asn Gly Glu Leu Gly Phe Leu Leu Pro Ser Gly Pro Gly Pro Thr Ser 
                325                 330                 335     


Gly Gly Gly Gly Pro Ser Trp Lys Pro Val Asp Leu His Gly Asn Glu 
            340                 345                 350         


Ile Leu Ser Gly Gly Gly Gly Pro Gly Gly Ala Gly Gln Ala Val His 
        355                 360                 365             


Gly Pro Val Lys Leu Gly Gly Thr Pro Pro Ala Asp Gly Lys Arg Phe 
    370                 375                 380                 


Gly Cys Leu Cys Gly Lys Arg Phe Ala Val Lys Pro Lys Arg Asp Arg 
385                 390                 395                 400 


His Ile Met Leu Thr Phe Ser Leu Arg Pro Phe Gly Cys Gly Ile Cys 
                405                 410                 415     


Asn Lys Arg Phe Lys Leu Lys His His Leu Thr Glu His Met Lys Thr 
            420                 425                 430         


His Ala Gly Ala Leu His Ala Cys Pro His Cys Gly Arg Arg Phe Arg 
        435                 440                 445             


Val His Ala Cys Phe Leu Arg His Arg Asp Leu Cys Lys Gly Gln Gly 
    450                 455                 460                 


Trp Ala Thr Ala His Trp Thr Tyr Lys 
465                 470             


<210>  1755
<211>  2203
<212>  DNA
<213>  Homosapiens

<400>  1755
gtctgcatcc ggtggccaca gagcaacttc ctctagaggg agctgattgg agccgggtgc     60

cgctggcacc tctatgatca ctggagtctc gcgggtccct cgggctgcac agggacaagt    120

aaaggctaca tccagatgcc gggaatgcac tgacgcccat tcctggaaac tgggctccca    180

ctcagcccct gggagcagca gccgccagcc cctcgggacc tccatctcca ccctgctgag    240

ccacccgggt tgggccagga tcccggcagg ctgatcccgt cctccactga gacctgaaaa    300

atggcttcgg ggcaaggccc aggtcctccc aggcaggagt gcggagagcc tgccctgccc    360

tctgcttctg aggagcaggt agcccaggac acagaggagg ttttccgcag ctacgttttt    420

taccgccatc agcaggaaca ggaggctgaa ggggtggctg cccctgccga cccagagatg    480

gtcaccttac ctctgcaacc tagcagcacc atggggcagg tgggacggca gctcgccatc    540

atcggggacg acatcaaccg acgctatgac tcagagttcc agaccatgtt gcagcacctg    600

cagcccacgg cagagaatgc ctatgagtac ttcaccaaga ttgccaccag cctgtttgag    660

agtggcatca attggggccg tgtggtggct cttctgggct tcggctaccg tctggcccta    720

cacgtctacc agcatggcct gactggcttc ctaggccagg tgacccgctt cgtggtcgac    780

ttcatgctgc atcactgcat tgcccggtgg attgcacaga ggggtggctg ggtggcagcc    840

ctgaacttgg gcaatggtcc catcctgaac gtgctggtgg ttctgggtgt ggttctgttg    900

ggccagtttg tggtacgaag attcttcaaa tcatgactcc caagggtgcc ctttggggtc    960

ccggttcaga cccctgcctg gacttaagcg aagtctttgc cttctctgtt cccttgcagg   1020

ggtcccccct caagagtaca gaagctttag caagtgtgca ctccagcttc ggagggcccc   1080

tgcgtggggg ccagtcaggc tgcagaggca cctcaacatt gcatggtgct agtgggccct   1140

ctctctgggc ccaggggctg tggccgtctc ctccctcagc tctctgggac ctccttagcc   1200

ctgtctgcta ggcgctgggg agactgataa cttggggagg caagagactg ggagccactt   1260

ctccccagaa agtgtttaac ggttttagct ttttataata cccttgtgag agcccattcc   1320

caccattcta cctgaggcca ggacgtctgg ggtgtgggga ttggtgggtc tatgttcccc   1380

aggattcagc tattctggaa gatcagcacc ctaagagatg ggactaggac ctgagcctgg   1440

tcctggccgt ccctaagcat gtgtcccagg agcaggacct actaggagag gggggccaag   1500

gtcctgctca actctacccc tgctcccatt cctccctccg gccatactgc ctttgcagtt   1560

ggactctcag ggattctggg cttggggtgt ggggtggggt ggagtcgcag accagagctg   1620

tctgaactca cgtgtcagaa gcctccaagc ctgcctccca aggtcctctc agttctctcc   1680

cttcctctct ccttatagac acttgctccc aacccattca ctacaggtga aggctctcac   1740

ccccatccct gggggccttg ggtgagtggc ctgctaaggc tcctccttgc ccagactaca   1800

gggcttagga cttggtttgt tatatcaggg aaaaggagta gggagttcat ctggagggtt   1860

ctaagtggga gaaggactat caacaccact aggaatccca gaggtgggat cctccctcat   1920

ggctctggca cagtgtaatc caggggtgta gatgggggaa ctgtgaatac ttgaactctg   1980

ttcccccacc ctccatgctc ctcacctgtc taggtctcct cagggtgggg ggtgacagtg   2040

ccttctctat tgggcacagc ctagggtctt gggggtcagg ggggagaagt tcttgattca   2100

gccaaatgca gggaggggag gcagatggag cccataggcc accccctatc ctctgagtgt   2160

ttggaaataa actgtgcaat cccctcaccc tgaaaaaaaa aaa                     2203


<210>  1756
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  1756

Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu 
1               5                   10                  15      


Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Thr Glu 
            20                  25                  30          


Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Glu Gln Glu 
        35                  40                  45              


Ala Glu Gly Val Ala Ala Pro Ala Asp Pro Glu Met Val Thr Leu Pro 
    50                  55                  60                  


Leu Gln Pro Ser Ser Thr Met Gly Gln Val Gly Arg Gln Leu Ala Ile 
65                  70                  75                  80  


Ile Gly Asp Asp Ile Asn Arg Arg Tyr Asp Ser Glu Phe Gln Thr Met 
                85                  90                  95      


Leu Gln His Leu Gln Pro Thr Ala Glu Asn Ala Tyr Glu Tyr Phe Thr 
            100                 105                 110         


Lys Ile Ala Thr Ser Leu Phe Glu Ser Gly Ile Asn Trp Gly Arg Val 
        115                 120                 125             


Val Ala Leu Leu Gly Phe Gly Tyr Arg Leu Ala Leu His Val Tyr Gln 
    130                 135                 140                 


His Gly Leu Thr Gly Phe Leu Gly Gln Val Thr Arg Phe Val Val Asp 
145                 150                 155                 160 


Phe Met Leu His His Cys Ile Ala Arg Trp Ile Ala Gln Arg Gly Gly 
                165                 170                 175     


Trp Val Ala Ala Leu Asn Leu Gly Asn Gly Pro Ile Leu Asn Val Leu 
            180                 185                 190         


Val Val Leu Gly Val Val Leu Leu Gly Gln Phe Val Val Arg Arg Phe 
        195                 200                 205             


Phe Lys Ser 
    210     


<210>  1757
<211>  2107
<212>  DNA
<213>  Homosapiens

<400>  1757
agatgcgagc gcctgcgcag gtacgcacgc tccgctggag cctggggtgg cctggcagtc     60

gtggccgaga cgtgtttgct gcacttcggt gcgcacaggc actgcggtgc caacctcttg    120

gttccgccct ccccccgcag gcgcccacgc gtgacctcgg ccgcccacag gccttcgact    180

cttcccggac tccaggtccc aggccgcccc gctccaccct gcggatgatg gagacaaagt    240

cccccacaag cccctcatat ggggcaaggg ggaaggtacc acctggggcg gggcctggct    300

ccccactgag cagaggtgct ggccaaggcg ctccccttag tgagacaagg tttcaccatg    360

ttgcccaggc ttttctcaaa ctcctgagct caagcaatcc gcccacctca gcctccgaaa    420

gtgctaggat tataggcgtg agccactgca cccagcccca ggtggcaagt ctttctgata    480

ggcactgctc caaagtgaat cacactgtgc taagcccccg caagggagtg cctttgcagc    540

ttacagctgc acactcgtca tctcaggagg tccttgcaac agtccccttt cacgggtaaa    600

gaaactgagg cctctactca acctcacaga gcaagctaat gccagactaa aacctctggc    660

ctccaaaccc catgcccttt ctttttgtaa gctacacaga ctgtcagggc aaatgtccac    720

tggataaaag catgagatga tgaatggacg gaaattaacc aaaaaggtca tcaacacatt    780

ttcaacagat ccatcaatgt gcactcaaag aagctgagac aggcctaacc tttaaaggct    840

gatgtcaagg aaggggagca gcaggatggt actcggtctg acccaggggg gtcgctcccc    900

tgagcctatg tgtgtttgga gtggacgaga atgggagaga gattagaaaa acagcagcat    960

catgtgaatt acagatgcac aggaaagctt acagcctgtc tagacaaatt cacttatgtt   1020

acagatgagg aaactgaggc tcagaaagag gaagggactt gcccaaggcc acatagcaaa   1080

ggaatagcaa agttgagaca aaaataatgg acattgtgac tctgagtcaa gtgagaaaca   1140

gagagactga tggagaagtg tgtgtgtgtg tgtgtgtgtg tgtgtgttta tgtgcatgca   1200

gtgtgcactc actcaggggg ccagggtcct gaatttagaa acactaccac caagaaggca   1260

ttatgcctac cctacccagg cagtgggggc tggagccagg gcctgggggc tggaaccagg   1320

gcccagggcc tggaggggat ggtaagcctc cagccccacc ttctccagga aggggttggt   1380

ggtctggcac gggccaagcg tacctggcca tccacaatgc tcacctccac cacggtgatc   1440

tctggccggg taagcagctc tcggccctct tggctgccta gcttccagag gcgggactct   1500

tgctgcattc ccagaagctt cttcaactcc gactccagga aacctgagag ccagagagat   1560

ggcaagggac agggagatgg cagggaacag gcaggagtag gatggagcag cccactggga   1620

acccaaggac ccggaggtgc aaccgctccc tgagcctcat cccagctctg tgtggttcct   1680

gctcaccctc agccacagcc ctctcttctt ccaggacgta gagccagcca ggtaccaccc   1740

ctccttcgcc ctgccttccc caggaagctc actctttgag ggccttctct ggcagcggca   1800

gcatgagagc ctgcgtcttc acccactggg gacagcatgc aaggggcagg tatttgcccc   1860

caccaccaac caactcaaga gcctggatct ggaacccaaa ctgcctgcac tcaagtccca   1920

gctctgccca tcactagctg tgtgacatcg ggcaagttct cactgtgaac tggagatggc   1980

aataggacct acctcagagt cgtaaaatgc aggattttat gaaaagtgct taaagagggt   2040

ctgccccatt aatggctatg taaatgtgaa ccacgatttt catcatatta tgtatgctat   2100

caccact                                                             2107


<210>  1758
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  1758

Met Arg Ala Pro Ala Gln Val Arg Thr Leu Arg Trp Ser Leu Gly Trp 
1               5                   10                  15      


Pro Gly Ser Arg Gly Arg Asp Val Phe Ala Ala Leu Arg Cys Ala Gln 
            20                  25                  30          


Ala Leu Arg Cys Gln Pro Leu Gly Ser Ala Leu Pro Pro Gln Ala Pro 
        35                  40                  45              


Thr Arg Asp Leu Gly Arg Pro Gln Ala Phe Asp Ser Ser Arg Thr Pro 
    50                  55                  60                  


Gly Pro Arg Pro Pro Arg Ser Thr Leu Arg Met Met Glu Thr Lys Ser 
65                  70                  75                  80  


Pro Thr Ser Pro Ser Tyr Gly Ala Arg Gly Lys Val Pro Pro Gly Ala 
                85                  90                  95      


Gly Pro Gly Ser Pro Leu Ser Arg Gly Ala Gly Gln Gly Ala Pro Leu 
            100                 105                 110         


Ser Glu Thr Arg Phe His His Val Ala Gln Ala Phe Leu Lys Leu Leu 
        115                 120                 125             


Ser Ser Ser Asn Pro Pro Thr Ser Ala Ser Glu Ser Ala Arg Ile Ile 
    130                 135                 140                 


Gly Val Ser His Cys Thr Gln Pro Gln Val Ala Ser Leu Ser Asp Arg 
145                 150                 155                 160 


His Cys Ser Lys Val Asn His Thr Val Leu Ser Pro Arg Lys Gly Val 
                165                 170                 175     


Pro Leu Gln Leu Thr Ala Ala His Ser Ser Ser Gln Glu Val Leu Ala 
            180                 185                 190         


Thr Val Pro Phe His Gly 
        195             


<210>  1759
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1759
cgccccccac gccctgggcc ccggagggcc gcagccatga gtgaaatgtc cagctttctt     60

cacatcgggg acatcgtctc cctgtacgcc gagggctccg tcaatggctt catcagcact    120

ttggggctgg tggatgaccg ctgtgtggtg gagcccgcgg ccggggacct ggacaacccc    180

cctaagaagt tccgtgactg cctcttcaag gtgtgcccca tgaaccgcta ctcggcccag    240

aagcagtact ggaaggccaa gcagactaag caggacaagg agaagatcgc tgatgtggtg    300

ttgctgcaga agctgcagca tgcggcgcag atggagcaga agcaaaatga cacggagaac    360

aagaaggtgc atggggatgt cgtgaagtat ggcagtgtga tccagctcct gcacatgaag    420

agcaacaagt acctgacagt gaacaagcgg cttccggcct tgctggagaa gaacgccatg    480

cgggtgactc tggatgccac aggcaacgag ggttcctggc tcttcatcca gcccttctgg    540

aagctgcgga gcaacgggga caacgtggtc gtgggggaca aggtgatcct gaatcctgtc    600

aatgccgggc agcctctgca tgccagcaat tacgagctca gcgacaacgc cggctgcaag    660

gaggtcaatt ctgtgaactg caacaccagc tggaagatca acctgtttat gcagtttcgg    720

gaccacctgg aggaggtgtt gaaaggggga gacgtggtgc ggctgttcca tgcggagcag    780

gagaagttcc tgacgtgtga cgagtacaag ggcaagctgc aggtgttcct gcgaactaca    840

ctgcgccagt ctgccacctc ggccaccagc tccaatgctc tctgggaggt ggaggtggtc    900

caccacgacc cctgccgtgg aggagctggg cactggaatg gcttgtaccg cttcaagcac    960

ctggctacag gcaactacct ggctgctgag gagaacccca gttacaaagg tgatgcctca   1020

gatcccaagg cagcaggaat gggggcacag ggccgcacag gccgcaggaa tgctggggag   1080

aagatcaagt actgcctggt ggctgtgcct catggcaatg acatcgcctc tctctttgag   1140

ctggacccca ccaccttgca gaaaaccgac tctttcgtgc cccggaactc gtacgtccgg   1200

ctgcggcacc tctgcaccaa cacgtggatt cagagcacca atgtgcccat tgacatcgag   1260

gaggagcggc ccatccggct catgctgggc acctgcccca ccaaggagga caaggaggcc   1320

tttgccatcg tgtcagtgcc cgtgtctgag atccgagacc tggactttgc caatgacgcc   1380

agctccatgc tggccagtgc cgtggagaaa ctcaacgagg gcttcatcag ccagaatgac   1440

cgcaggtttg tcatccagct gctggaagac ctggtgttct ttgtcagcga tgtccccaac   1500

aatgggcaga atgtcctgga catcatggtc actaagccca accgggaacg gcagaagctg   1560

atgagggagc agaacatcct caaacaggtc tttggcattc tgaaggtccc gttccgtgag   1620

aaggggggtg aaggtcccct ggtgcggctg gaggagctgt cagaccagaa gaacgccccc   1680

taccagcaca tgttccgcct gtgctaccgt gtgttgcggt attcccagga ggactaccgc   1740

aagaaccagg agcacattgc caagcagttt gggatgatgc agtcccagat tggctacgac   1800

atcctggccg aggacaccat cactgccctg ctgcacaaca accgcaagct cctggaaaag   1860

cacatcacca agaccgaggt ggagaccttc gtcagccttg tgcgcaagaa ccgggagccc   1920

aggttcctgg actacctctc tgacctgtgt gtgtccaacc acatcgccat ccccgtcacc   1980

caagagctca tctgcaagtg tgtgctggac cccaagaaca gtgacattct catccggacc   2040

gagcttcggc ccgtgaagga gatggcccaa tcccacgagt acctgagcat cgagtactca   2100

gaagaggaag tgtggctcac gtggactgac aagaataacg agcatcatga gaagagtgtg   2160

aggcagctgg cccaggaggc gcgggccggc aacgcccacg acgagaatgt gctcagctac   2220

tacaggtacc agctgaagct ctttgcccgc atgtgcttgg accgccagta cttggccatc   2280

gacgagatct cccagcagct gggcgtggac ctgattttcc tgtgcatggc agacgagatg   2340

ctgccctttg acctgcgcgc ctccttctgc cacctgatgc tgcacgtgca cgtggaccgt   2400

gacccccagg agctggtcac gccggtcaag tttgcccgtc tctggactga gatccccaca   2460

gccatcacca tcaaggacta tgattccaac ctcaacgcgt cccgagatga caagaagaac   2520

aagtttgcca acaccatgga gttcgtggag gactacctca acaatgtagt cagcgaggcc   2580

gtgccctttg ccaacgagga gaagaacaag ctcacttttg aggtggtcag cctggcgcac   2640

aatctcatct acttcggctt ctacagcttc agcgagctgc tgcggctcac tcgcacactg   2700

ctgggcatca tcgactgtgt gcaggggccc ccggccatgc tgcaggccta tgaggacccc   2760

ggtggcaaga atgtgcggcg gtccatccag ggcgtggggc acatgatgtc caccatggtg   2820

ctgagccgca agcagtccgt cttcagtgcc cccagcctgt ctgctggggc cagtgctgct   2880

gagccgctgg acagaagcaa gtttgaggag aatgaggaca ttgtggtgat ggagaccaag   2940

ctgaagatcc tggaaatcct tcagttcatc ctcaacgtcc gcctggatta ccgcatatcc   3000

tacctgctgt ctgtcttcaa gaaggagttt gtggaggtgt ttcccatgca ggacagtggg   3060

gctgatggca cagcccctgc cttcgactct accactgcca acatgaacct ggatcgcatc   3120

ggggagcagg cggaggccat gtttggagtg gggaagacaa gcagcatgct ggaggtggat   3180

gacgagggcg gccgcatgtt cctgcgcgtg ctcatccacc tcaccatgca cgactatgcg   3240

ccactggtct cgggtgccct gcagctgctc ttcaagcact tcagccagcg ccaggaggcc   3300

atgcacacct tcaagcaggt tcagctgctg atctcagcgc aggacgtgga gaactacaag   3360

gtgatcaagt cggagctgga ccggctgcgg accatggtgg agaagtcaga gctgtgggtg   3420

gacaagaagg gcagtggcaa gggtgaggag gtggaggcag gcaccgccaa ggacaagaaa   3480

gagcgtccca cggacgagga gggctttctg cacccaccag gggagaaaag cagtgagaac   3540

taccagatcg tcaagggcat cctggaaagg ctgaacaaga tgtgcggggt tggggagcaa   3600

atgaggaaga agcagcaacg gctgctgaag aacatggatg cccacaaggt catgctggac   3660

ctgctgcaga tcccctatga caagggtgat gccaagatga tggagatcct gcgctacacg   3720

caccagttcc tgcagaagtt ctgtgcaggg aaccccggca accaggccct gctgcacaaa   3780

cacctgcacc tcttcctcac gccagggctc ctggaggcag agaccatgca gcacatcttc   3840

ctgaacaact atcagctctg ctccgagatc agcgagcctg tgttgcagca cttcgtgcac   3900

ctgctggcca cgcacgggcg ccatgtgcag tacctggact tcctgcacac cgtcattaag   3960

gccgagggca agtacgtcaa gaagtgccag gacatgatca tgactgagct gaccaatgca   4020

ggtgacgatg tggtcgtgtt ctacaatgat aaggcatcgc tggcccacct gctggacatg   4080

atgaaggccg cccgcgacgg cgtggaggac cacagccccc tcatgtacca catttccctg   4140

gtggacctgc tggccgcctg tgccgagggc aaaaacgtct acactgagat caagtgcacc   4200

tccctcgtgc cgctggagga cgtggtgtct gtggtgacgc atgaggactg catcactgag   4260

gtgaaaatgg cctatgtgaa cttcgtgaac cactgctacg tggacacgga ggtggagatg   4320

aaggagatct acaccagcaa ccacatctgg acgctctttg agaacttcac cctggacatg   4380

gctcgggtct gcagcaagcg tgagaagcgc gtggctgacc ccaccttgga gaagtacgtg   4440

ctgagcgttg tgctggacac catcaacgcc ttcttcagct ccccattctc tgagaacagc   4500

acttccctgc agacacacca gccggttgtg gtgcagctgc tgcagtctac cacacgcctc   4560

ctcgagtgtc cgtggctaca gcagcagcac aagggctccg tggaggcctg catccggacc   4620

ctcgccatgg tggccaaggg ccgggccatc ttgctgccca tggacctgga tgcccacatc   4680

agctcgatgc tcagcagtgg agccagctgt gcagctgccg cccagcggaa cgcctccagc   4740

tacaaggcaa ccacgcgggc cttcccccgc gtcaccccca ccgccaacca gtgggactac   4800

aagaacatca ttgagaagct gcaggacatc atcacagccc tggaggagcg gctgaagccc   4860

ctggtacagg ctgagctgtc cgtgctggtg gatgtcctgc actggcctga gctgctcttc   4920

ctggagggca gtgaggccta ccagcgctgc gagagtgggg gcttcctgtc caagctgatc   4980

cagcacacca aggacctcat ggagtcggag gagaagctgt gcatcaaggt gctgcggacc   5040

ctgcagcaga tgctcgtcaa gaagaccaag tacggggacc ggggcaacca gctgcgcaag   5100

atgctgctgc aaaactacct ccagaaccgg aagtccacct cgcgggggga ccttcccgac   5160

cccataggca ctggcctgga cccagactgg tcggcaatcg cagccaccca gtgccggctg   5220

gacaaggagg gggccaccaa gttggtatgc gacctcatca ccagcaccaa gaacgagaag   5280

atcttccagg agagcatcgg cctggccatc cacctgctgg atggtggcaa cacagagatc   5340

cagaaatcct tccacaacct gatgatgagt gacaagaagt cagagcgctt cttcaaggtg   5400

ctgcacgacc gcatgaagcg ggcccagcag gagaccaagt ccacggtggc agtcaacatg   5460

aatgacctgg gcagccagcc acatgaggac cgcgagccag tcgaccccac caccaaaggc   5520

cgcgtggcct ccttctcgat acctggctcc tcatcccgct actcgctggg ccccagcctg   5580

cgccgggggc acgaggtgag cgaacgtgtg cagagcagtg agatgggcac atccgtgctc   5640

atcatgcagc ccatcctgcg ctttctgcag ctgctgtgtg agaaccacaa ccgggacctg   5700

cagaacttcc tgcgctgtca gaacaacaaa accaactaca acttggtatg cgagacgctg   5760

cagttcctgg acatcatgtg cggcagcacc acgggcggcc tggggctgct ggggctctac   5820

atcaatgagg acaacgtggg cctcgtcatc cagaccttgg agaccctcac tgagtactgc   5880

cagggcccct gccatgagaa ccagacttgc attgtgactc acgagtccaa tggcatagac   5940

atcatcaccg cactgatcct caatgacatc agccccctgt gcaagtaccg catggatctg   6000

gtgctgcagc tcaaggacaa tgcctccaag ctgctcctgg ctctgatgga gagccggcat   6060

gacagtgaaa atgctgagcg aatcctcatc agcctgcggc cccaggagct ggtggacgtc   6120

atcaagaagg cctacctgca ggaggaagag cgtgagaact cggaggtgag cccacgtgaa   6180

gtgggccata acatctatat cctggcgctg cagctctcca ggcacaataa acagctgcag   6240

cacctgctga agccggtgaa gcgcattcaa gaggaggagg ccgagggtat ctcttccatg   6300

ctcagcctca acaacaagca gctgtcacag atgctcaagt cctcagcgcc agcacaggag   6360

gaggaggaag accccctggc ctactatgag aaccacacgt cccagatcga gattgtgcgg   6420

caggaccgca gcatggagca gatcgtgttc ccagtgcccg gcatctgcca gttcctgacg   6480

gaggaaacca agcaccggct cttcaccact actgagcagg acgagcaggg cagcaaagtg   6540

agcgacttct tcgaccagtc ctccttcctg cacaacgaga tggagtggca gcgcaacgtc   6600

cgcagcatgc cgctgatcta ctggttctcc cgccgcatga ccctgtgggg cagcatctcc   6660

ttcaacctgg ccgtgtttat caacatcatc attgccttct tctaccctta catggagggc   6720

gcgtccacag gcgtgctgga ctcccctctc atctcattgc tcttctggat cctcatctgc   6780

ttctccatcg cggccctgtt caccaagcgc tacagcatcc gccccctcat cgtggcgctc   6840

atcctgcgct ccatctacta tctgggcatc gggcccacac tcaacatcct gggtgccctc   6900

aatctgacca acaagatcgt gtttgtggtg agcttcgtgg gcaaccgtgg caccttcatc   6960

cggggctata aggccatggt catggacatg gaattcctct accacgtggg ctacatcctg   7020

accagtgtcc tgggcctctt tgctcatgag ctgttctaca gcatcctgct ctttgacctc   7080

atctaccgcg aggagacgct gttcaacgtc atcaagagtg tgacccgcaa tggccgctcc   7140

atcctgctga cagccctgct ggccctcatc ctggtctacc tcttctccat cgtcggcttc   7200

ctcttcctca aggatgactt cattctcgag gtcgaccggc tgcccaacaa ccactccaca   7260

gccagccccc tggggatgcc acatggagct gctgcatttg tggacacctg cagtggggac   7320

aagatggact gtgtctcagg gctctcggtg cctgaggtcc tggaagagga cagggagctg   7380

gacagcacag agcgggcctg tgacactctg ttgatgtgca tcgtcactgt catgaaccat   7440

gggctacgca acggtggtgg cgtgggcgac attctccgca agccctccaa agatgagtct   7500

ctcttcccag cccgagtggt ctatgacctc ctgttcttct tcatcgtcat catcattgtg   7560

ctgaacctca tctttggggt aatcatcgac accttcgctg acctgcgtag tgagaagcag   7620

aagaaggagg agattcttaa gacgacatgc ttcatctgtg gtctggagag ggacaagttt   7680

gataacaaga cagtgtcatt tgaggaacac atcaagctgg agcacaacat gtggaactac   7740

ttgtacttca ttgtgctggt ccgcgtgaag aacaagaccg actacacggg ccctgagagc   7800

tacgtggccc agatgatcaa gaacaagaac ctggactggt tcccccggat gcgggccatg   7860

tcccttgtca gcaatgaggg cgagggggag cagaatgaga ttcggattct ccaggacaag   7920

ctcaactcca ccatgaagct ggtgtcccac ctcactgccc agctcaacga gctcaaggag   7980

cagatgacgg agcagcggaa acgcaggcaa cgcctaggct ttgtggatgt ccagaactgc   8040

attagccgct gaggagagcc accgaaggcc ccaacagggg atgctcatca ctggagactg   8100

cgactgggaa gaacactgcc ccctccctcg ggttgggtgg cccagccagc tggccagcct   8160

ccactcccac tctgccagac accctgacac cc                                 8192


<210>  1760
<211>  2671
<212>  PRT
<213>  Homosapiens

<400>  1760

Met Ser Glu Met Ser Ser Phe Leu His Ile Gly Asp Ile Val Ser Leu 
1               5                   10                  15      


Tyr Ala Glu Gly Ser Val Asn Gly Phe Ile Ser Thr Leu Gly Leu Val 
            20                  25                  30          


Asp Asp Arg Cys Val Val Glu Pro Ala Ala Gly Asp Leu Asp Asn Pro 
        35                  40                  45              


Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Val Cys Pro Met Asn Arg 
    50                  55                  60                  


Tyr Ser Ala Gln Lys Gln Tyr Trp Lys Ala Lys Gln Thr Lys Gln Asp 
65                  70                  75                  80  


Lys Glu Lys Ile Ala Asp Val Val Leu Leu Gln Lys Leu Gln His Ala 
                85                  90                  95      


Ala Gln Met Glu Gln Lys Gln Asn Asp Thr Glu Asn Lys Lys Val His 
            100                 105                 110         


Gly Asp Val Val Lys Tyr Gly Ser Val Ile Gln Leu Leu His Met Lys 
        115                 120                 125             


Ser Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu 
    130                 135                 140                 


Lys Asn Ala Met Arg Val Thr Leu Asp Ala Thr Gly Asn Glu Gly Ser 
145                 150                 155                 160 


Trp Leu Phe Ile Gln Pro Phe Trp Lys Leu Arg Ser Asn Gly Asp Asn 
                165                 170                 175     


Val Val Val Gly Asp Lys Val Ile Leu Asn Pro Val Asn Ala Gly Gln 
            180                 185                 190         


Pro Leu His Ala Ser Asn Tyr Glu Leu Ser Asp Asn Ala Gly Cys Lys 
        195                 200                 205             


Glu Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Asn Leu Phe 
    210                 215                 220                 


Met Gln Phe Arg Asp His Leu Glu Glu Val Leu Lys Gly Gly Asp Val 
225                 230                 235                 240 


Val Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu 
                245                 250                 255     


Tyr Lys Gly Lys Leu Gln Val Phe Leu Arg Thr Thr Leu Arg Gln Ser 
            260                 265                 270         


Ala Thr Ser Ala Thr Ser Ser Asn Ala Leu Trp Glu Val Glu Val Val 
        275                 280                 285             


His His Asp Pro Cys Arg Gly Gly Ala Gly His Trp Asn Gly Leu Tyr 
    290                 295                 300                 


Arg Phe Lys His Leu Ala Thr Gly Asn Tyr Leu Ala Ala Glu Glu Asn 
305                 310                 315                 320 


Pro Ser Tyr Lys Gly Asp Ala Ser Asp Pro Lys Ala Ala Gly Met Gly 
                325                 330                 335     


Ala Gln Gly Arg Thr Gly Arg Arg Asn Ala Gly Glu Lys Ile Lys Tyr 
            340                 345                 350         


Cys Leu Val Ala Val Pro His Gly Asn Asp Ile Ala Ser Leu Phe Glu 
        355                 360                 365             


Leu Asp Pro Thr Thr Leu Gln Lys Thr Asp Ser Phe Val Pro Arg Asn 
    370                 375                 380                 


Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Ile Gln Ser 
385                 390                 395                 400 


Thr Asn Val Pro Ile Asp Ile Glu Glu Glu Arg Pro Ile Arg Leu Met 
                405                 410                 415     


Leu Gly Thr Cys Pro Thr Lys Glu Asp Lys Glu Ala Phe Ala Ile Val 
            420                 425                 430         


Ser Val Pro Val Ser Glu Ile Arg Asp Leu Asp Phe Ala Asn Asp Ala 
        435                 440                 445             


Ser Ser Met Leu Ala Ser Ala Val Glu Lys Leu Asn Glu Gly Phe Ile 
    450                 455                 460                 


Ser Gln Asn Asp Arg Arg Phe Val Ile Gln Leu Leu Glu Asp Leu Val 
465                 470                 475                 480 


Phe Phe Val Ser Asp Val Pro Asn Asn Gly Gln Asn Val Leu Asp Ile 
                485                 490                 495     


Met Val Thr Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu Gln 
            500                 505                 510         


Asn Ile Leu Lys Gln Val Phe Gly Ile Leu Lys Val Pro Phe Arg Glu 
        515                 520                 525             


Lys Gly Gly Glu Gly Pro Leu Val Arg Leu Glu Glu Leu Ser Asp Gln 
    530                 535                 540                 


Lys Asn Ala Pro Tyr Gln His Met Phe Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg Tyr Ser Gln Glu Asp Tyr Arg Lys Asn Gln Glu His Ile Ala Lys 
                565                 570                 575     


Gln Phe Gly Met Met Gln Ser Gln Ile Gly Tyr Asp Ile Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Lys Thr Glu Val Glu Thr Phe Val Ser Leu Val Arg Lys 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Asn His Ile Ala Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Cys Val 
                645                 650                 655     


Leu Asp Pro Lys Asn Ser Asp Ile Leu Ile Arg Thr Glu Leu Arg Pro 
            660                 665                 670         


Val Lys Glu Met Ala Gln Ser His Glu Tyr Leu Ser Ile Glu Tyr Ser 
        675                 680                 685             


Glu Glu Glu Val Trp Leu Thr Trp Thr Asp Lys Asn Asn Glu His His 
    690                 695                 700                 


Glu Lys Ser Val Arg Gln Leu Ala Gln Glu Ala Arg Ala Gly Asn Ala 
705                 710                 715                 720 


His Asp Glu Asn Val Leu Ser Tyr Tyr Arg Tyr Gln Leu Lys Leu Phe 
                725                 730                 735     


Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala Ile Asp Glu Ile Ser 
            740                 745                 750         


Gln Gln Leu Gly Val Asp Leu Ile Phe Leu Cys Met Ala Asp Glu Met 
        755                 760                 765             


Leu Pro Phe Asp Leu Arg Ala Ser Phe Cys His Leu Met Leu His Val 
    770                 775                 780                 


His Val Asp Arg Asp Pro Gln Glu Leu Val Thr Pro Val Lys Phe Ala 
785                 790                 795                 800 


Arg Leu Trp Thr Glu Ile Pro Thr Ala Ile Thr Ile Lys Asp Tyr Asp 
                805                 810                 815     


Ser Asn Leu Asn Ala Ser Arg Asp Asp Lys Lys Asn Lys Phe Ala Asn 
            820                 825                 830         


Thr Met Glu Phe Val Glu Asp Tyr Leu Asn Asn Val Val Ser Glu Ala 
        835                 840                 845             


Val Pro Phe Ala Asn Glu Glu Lys Asn Lys Leu Thr Phe Glu Val Val 
    850                 855                 860                 


Ser Leu Ala His Asn Leu Ile Tyr Phe Gly Phe Tyr Ser Phe Ser Glu 
865                 870                 875                 880 


Leu Leu Arg Leu Thr Arg Thr Leu Leu Gly Ile Ile Asp Cys Val Gln 
                885                 890                 895     


Gly Pro Pro Ala Met Leu Gln Ala Tyr Glu Asp Pro Gly Gly Lys Asn 
            900                 905                 910         


Val Arg Arg Ser Ile Gln Gly Val Gly His Met Met Ser Thr Met Val 
        915                 920                 925             


Leu Ser Arg Lys Gln Ser Val Phe Ser Ala Pro Ser Leu Ser Ala Gly 
    930                 935                 940                 


Ala Ser Ala Ala Glu Pro Leu Asp Arg Ser Lys Phe Glu Glu Asn Glu 
945                 950                 955                 960 


Asp Ile Val Val Met Glu Thr Lys Leu Lys Ile Leu Glu Ile Leu Gln 
                965                 970                 975     


Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser Tyr Leu Leu Ser 
            980                 985                 990         


Val Phe Lys Lys Glu Phe Val Glu  Val Phe Pro Met Gln  Asp Ser Gly 
        995                 1000                 1005             


Ala Asp  Gly Thr Ala Pro Ala  Phe Asp Ser Thr Thr  Ala Asn Met 
    1010                 1015                 1020             


Asn Leu  Asp Arg Ile Gly Glu  Gln Ala Glu Ala Met  Phe Gly Val 
    1025                 1030                 1035             


Gly Lys  Thr Ser Ser Met Leu  Glu Val Asp Asp Glu  Gly Gly Arg 
    1040                 1045                 1050             


Met Phe  Leu Arg Val Leu Ile  His Leu Thr Met His  Asp Tyr Ala 
    1055                 1060                 1065             


Pro Leu  Val Ser Gly Ala Leu  Gln Leu Leu Phe Lys  His Phe Ser 
    1070                 1075                 1080             


Gln Arg  Gln Glu Ala Met His  Thr Phe Lys Gln Val  Gln Leu Leu 
    1085                 1090                 1095             


Ile Ser  Ala Gln Asp Val Glu  Asn Tyr Lys Val Ile  Lys Ser Glu 
    1100                 1105                 1110             


Leu Asp  Arg Leu Arg Thr Met  Val Glu Lys Ser Glu  Leu Trp Val 
    1115                 1120                 1125             


Asp Lys  Lys Gly Ser Gly Lys  Gly Glu Glu Val Glu  Ala Gly Thr 
    1130                 1135                 1140             


Ala Lys  Asp Lys Lys Glu Arg  Pro Thr Asp Glu Glu  Gly Phe Leu 
    1145                 1150                 1155             


His Pro  Pro Gly Glu Lys Ser  Ser Glu Asn Tyr Gln  Ile Val Lys 
    1160                 1165                 1170             


Gly Ile  Leu Glu Arg Leu Asn  Lys Met Cys Gly Val  Gly Glu Gln 
    1175                 1180                 1185             


Met Arg  Lys Lys Gln Gln Arg  Leu Leu Lys Asn Met  Asp Ala His 
    1190                 1195                 1200             


Lys Val  Met Leu Asp Leu Leu  Gln Ile Pro Tyr Asp  Lys Gly Asp 
    1205                 1210                 1215             


Ala Lys  Met Met Glu Ile Leu  Arg Tyr Thr His Gln  Phe Leu Gln 
    1220                 1225                 1230             


Lys Phe  Cys Ala Gly Asn Pro  Gly Asn Gln Ala Leu  Leu His Lys 
    1235                 1240                 1245             


His Leu  His Leu Phe Leu Thr  Pro Gly Leu Leu Glu  Ala Glu Thr 
    1250                 1255                 1260             


Met Gln  His Ile Phe Leu Asn  Asn Tyr Gln Leu Cys  Ser Glu Ile 
    1265                 1270                 1275             


Ser Glu  Pro Val Leu Gln His  Phe Val His Leu Leu  Ala Thr His 
    1280                 1285                 1290             


Gly Arg  His Val Gln Tyr Leu  Asp Phe Leu His Thr  Val Ile Lys 
    1295                 1300                 1305             


Ala Glu  Gly Lys Tyr Val Lys  Lys Cys Gln Asp Met  Ile Met Thr 
    1310                 1315                 1320             


Glu Leu  Thr Asn Ala Gly Asp  Asp Val Val Val Phe  Tyr Asn Asp 
    1325                 1330                 1335             


Lys Ala  Ser Leu Ala His Leu  Leu Asp Met Met Lys  Ala Ala Arg 
    1340                 1345                 1350             


Asp Gly  Val Glu Asp His Ser  Pro Leu Met Tyr His  Ile Ser Leu 
    1355                 1360                 1365             


Val Asp  Leu Leu Ala Ala Cys  Ala Glu Gly Lys Asn  Val Tyr Thr 
    1370                 1375                 1380             


Glu Ile  Lys Cys Thr Ser Leu  Val Pro Leu Glu Asp  Val Val Ser 
    1385                 1390                 1395             


Val Val  Thr His Glu Asp Cys  Ile Thr Glu Val Lys  Met Ala Tyr 
    1400                 1405                 1410             


Val Asn  Phe Val Asn His Cys  Tyr Val Asp Thr Glu  Val Glu Met 
    1415                 1420                 1425             


Lys Glu  Ile Tyr Thr Ser Asn  His Ile Trp Thr Leu  Phe Glu Asn 
    1430                 1435                 1440             


Phe Thr  Leu Asp Met Ala Arg  Val Cys Ser Lys Arg  Glu Lys Arg 
    1445                 1450                 1455             


Val Ala  Asp Pro Thr Leu Glu  Lys Tyr Val Leu Ser  Val Val Leu 
    1460                 1465                 1470             


Asp Thr  Ile Asn Ala Phe Phe  Ser Ser Pro Phe Ser  Glu Asn Ser 
    1475                 1480                 1485             


Thr Ser  Leu Gln Thr His Gln  Pro Val Val Val Gln  Leu Leu Gln 
    1490                 1495                 1500             


Ser Thr  Thr Arg Leu Leu Glu  Cys Pro Trp Leu Gln  Gln Gln His 
    1505                 1510                 1515             


Lys Gly  Ser Val Glu Ala Cys  Ile Arg Thr Leu Ala  Met Val Ala 
    1520                 1525                 1530             


Lys Gly  Arg Ala Ile Leu Leu  Pro Met Asp Leu Asp  Ala His Ile 
    1535                 1540                 1545             


Ser Ser  Met Leu Ser Ser Gly  Ala Ser Cys Ala Ala  Ala Ala Gln 
    1550                 1555                 1560             


Arg Asn  Ala Ser Ser Tyr Lys  Ala Thr Thr Arg Ala  Phe Pro Arg 
    1565                 1570                 1575             


Val Thr  Pro Thr Ala Asn Gln  Trp Asp Tyr Lys Asn  Ile Ile Glu 
    1580                 1585                 1590             


Lys Leu  Gln Asp Ile Ile Thr  Ala Leu Glu Glu Arg  Leu Lys Pro 
    1595                 1600                 1605             


Leu Val  Gln Ala Glu Leu Ser  Val Leu Val Asp Val  Leu His Trp 
    1610                 1615                 1620             


Pro Glu  Leu Leu Phe Leu Glu  Gly Ser Glu Ala Tyr  Gln Arg Cys 
    1625                 1630                 1635             


Glu Ser  Gly Gly Phe Leu Ser  Lys Leu Ile Gln His  Thr Lys Asp 
    1640                 1645                 1650             


Leu Met  Glu Ser Glu Glu Lys  Leu Cys Ile Lys Val  Leu Arg Thr 
    1655                 1660                 1665             


Leu Gln  Gln Met Leu Val Lys  Lys Thr Lys Tyr Gly  Asp Arg Gly 
    1670                 1675                 1680             


Asn Gln  Leu Arg Lys Met Leu  Leu Gln Asn Tyr Leu  Gln Asn Arg 
    1685                 1690                 1695             


Lys Ser  Thr Ser Arg Gly Asp  Leu Pro Asp Pro Ile  Gly Thr Gly 
    1700                 1705                 1710             


Leu Asp  Pro Asp Trp Ser Ala  Ile Ala Ala Thr Gln  Cys Arg Leu 
    1715                 1720                 1725             


Asp Lys  Glu Gly Ala Thr Lys  Leu Val Cys Asp Leu  Ile Thr Ser 
    1730                 1735                 1740             


Thr Lys  Asn Glu Lys Ile Phe  Gln Glu Ser Ile Gly  Leu Ala Ile 
    1745                 1750                 1755             


His Leu  Leu Asp Gly Gly Asn  Thr Glu Ile Gln Lys  Ser Phe His 
    1760                 1765                 1770             


Asn Leu  Met Met Ser Asp Lys  Lys Ser Glu Arg Phe  Phe Lys Val 
    1775                 1780                 1785             


Leu His  Asp Arg Met Lys Arg  Ala Gln Gln Glu Thr  Lys Ser Thr 
    1790                 1795                 1800             


Val Ala  Val Asn Met Asn Asp  Leu Gly Ser Gln Pro  His Glu Asp 
    1805                 1810                 1815             


Arg Glu  Pro Val Asp Pro Thr  Thr Lys Gly Arg Val  Ala Ser Phe 
    1820                 1825                 1830             


Ser Ile  Pro Gly Ser Ser Ser  Arg Tyr Ser Leu Gly  Pro Ser Leu 
    1835                 1840                 1845             


Arg Arg  Gly His Glu Val Ser  Glu Arg Val Gln Ser  Ser Glu Met 
    1850                 1855                 1860             


Gly Thr  Ser Val Leu Ile Met  Gln Pro Ile Leu Arg  Phe Leu Gln 
    1865                 1870                 1875             


Leu Leu  Cys Glu Asn His Asn  Arg Asp Leu Gln Asn  Phe Leu Arg 
    1880                 1885                 1890             


Cys Gln  Asn Asn Lys Thr Asn  Tyr Asn Leu Val Cys  Glu Thr Leu 
    1895                 1900                 1905             


Gln Phe  Leu Asp Ile Met Cys  Gly Ser Thr Thr Gly  Gly Leu Gly 
    1910                 1915                 1920             


Leu Leu  Gly Leu Tyr Ile Asn  Glu Asp Asn Val Gly  Leu Val Ile 
    1925                 1930                 1935             


Gln Thr  Leu Glu Thr Leu Thr  Glu Tyr Cys Gln Gly  Pro Cys His 
    1940                 1945                 1950             


Glu Asn  Gln Thr Cys Ile Val  Thr His Glu Ser Asn  Gly Ile Asp 
    1955                 1960                 1965             


Ile Ile  Thr Ala Leu Ile Leu  Asn Asp Ile Ser Pro  Leu Cys Lys 
    1970                 1975                 1980             


Tyr Arg  Met Asp Leu Val Leu  Gln Leu Lys Asp Asn  Ala Ser Lys 
    1985                 1990                 1995             


Leu Leu  Leu Ala Leu Met Glu  Ser Arg His Asp Ser  Glu Asn Ala 
    2000                 2005                 2010             


Glu Arg  Ile Leu Ile Ser Leu  Arg Pro Gln Glu Leu  Val Asp Val 
    2015                 2020                 2025             


Ile Lys  Lys Ala Tyr Leu Gln  Glu Glu Glu Arg Glu  Asn Ser Glu 
    2030                 2035                 2040             


Val Ser  Pro Arg Glu Val Gly  His Asn Ile Tyr Ile  Leu Ala Leu 
    2045                 2050                 2055             


Gln Leu  Ser Arg His Asn Lys  Gln Leu Gln His Leu  Leu Lys Pro 
    2060                 2065                 2070             


Val Lys  Arg Ile Gln Glu Glu  Glu Ala Glu Gly Ile  Ser Ser Met 
    2075                 2080                 2085             


Leu Ser  Leu Asn Asn Lys Gln  Leu Ser Gln Met Leu  Lys Ser Ser 
    2090                 2095                 2100             


Ala Pro  Ala Gln Glu Glu Glu  Glu Asp Pro Leu Ala  Tyr Tyr Glu 
    2105                 2110                 2115             


Asn His  Thr Ser Gln Ile Glu  Ile Val Arg Gln Asp  Arg Ser Met 
    2120                 2125                 2130             


Glu Gln  Ile Val Phe Pro Val  Pro Gly Ile Cys Gln  Phe Leu Thr 
    2135                 2140                 2145             


Glu Glu  Thr Lys His Arg Leu  Phe Thr Thr Thr Glu  Gln Asp Glu 
    2150                 2155                 2160             


Gln Gly  Ser Lys Val Ser Asp  Phe Phe Asp Gln Ser  Ser Phe Leu 
    2165                 2170                 2175             


His Asn  Glu Met Glu Trp Gln  Arg Asn Val Arg Ser  Met Pro Leu 
    2180                 2185                 2190             


Ile Tyr  Trp Phe Ser Arg Arg  Met Thr Leu Trp Gly  Ser Ile Ser 
    2195                 2200                 2205             


Phe Asn  Leu Ala Val Phe Ile  Asn Ile Ile Ile Ala  Phe Phe Tyr 
    2210                 2215                 2220             


Pro Tyr  Met Glu Gly Ala Ser  Thr Gly Val Leu Asp  Ser Pro Leu 
    2225                 2230                 2235             


Ile Ser  Leu Leu Phe Trp Ile  Leu Ile Cys Phe Ser  Ile Ala Ala 
    2240                 2245                 2250             


Leu Phe  Thr Lys Arg Tyr Ser  Ile Arg Pro Leu Ile  Val Ala Leu 
    2255                 2260                 2265             


Ile Leu  Arg Ser Ile Tyr Tyr  Leu Gly Ile Gly Pro  Thr Leu Asn 
    2270                 2275                 2280             


Ile Leu  Gly Ala Leu Asn Leu  Thr Asn Lys Ile Val  Phe Val Val 
    2285                 2290                 2295             


Ser Phe  Val Gly Asn Arg Gly  Thr Phe Ile Arg Gly  Tyr Lys Ala 
    2300                 2305                 2310             


Met Val  Met Asp Met Glu Phe  Leu Tyr His Val Gly  Tyr Ile Leu 
    2315                 2320                 2325             


Thr Ser  Val Leu Gly Leu Phe  Ala His Glu Leu Phe  Tyr Ser Ile 
    2330                 2335                 2340             


Leu Leu  Phe Asp Leu Ile Tyr  Arg Glu Glu Thr Leu  Phe Asn Val 
    2345                 2350                 2355             


Ile Lys  Ser Val Thr Arg Asn  Gly Arg Ser Ile Leu  Leu Thr Ala 
    2360                 2365                 2370             


Leu Leu  Ala Leu Ile Leu Val  Tyr Leu Phe Ser Ile  Val Gly Phe 
    2375                 2380                 2385             


Leu Phe  Leu Lys Asp Asp Phe  Ile Leu Glu Val Asp  Arg Leu Pro 
    2390                 2395                 2400             


Asn Asn  His Ser Thr Ala Ser  Pro Leu Gly Met Pro  His Gly Ala 
    2405                 2410                 2415             


Ala Ala  Phe Val Asp Thr Cys  Ser Gly Asp Lys Met  Asp Cys Val 
    2420                 2425                 2430             


Ser Gly  Leu Ser Val Pro Glu  Val Leu Glu Glu Asp  Arg Glu Leu 
    2435                 2440                 2445             


Asp Ser  Thr Glu Arg Ala Cys  Asp Thr Leu Leu Met  Cys Ile Val 
    2450                 2455                 2460             


Thr Val  Met Asn His Gly Leu  Arg Asn Gly Gly Gly  Val Gly Asp 
    2465                 2470                 2475             


Ile Leu  Arg Lys Pro Ser Lys  Asp Glu Ser Leu Phe  Pro Ala Arg 
    2480                 2485                 2490             


Val Val  Tyr Asp Leu Leu Phe  Phe Phe Ile Val Ile  Ile Ile Val 
    2495                 2500                 2505             


Leu Asn  Leu Ile Phe Gly Val  Ile Ile Asp Thr Phe  Ala Asp Leu 
    2510                 2515                 2520             


Arg Ser  Glu Lys Gln Lys Lys  Glu Glu Ile Leu Lys  Thr Thr Cys 
    2525                 2530                 2535             


Phe Ile  Cys Gly Leu Glu Arg  Asp Lys Phe Asp Asn  Lys Thr Val 
    2540                 2545                 2550             


Ser Phe  Glu Glu His Ile Lys  Leu Glu His Asn Met  Trp Asn Tyr 
    2555                 2560                 2565             


Leu Tyr  Phe Ile Val Leu Val  Arg Val Lys Asn Lys  Thr Asp Tyr 
    2570                 2575                 2580             


Thr Gly  Pro Glu Ser Tyr Val  Ala Gln Met Ile Lys  Asn Lys Asn 
    2585                 2590                 2595             


Leu Asp  Trp Phe Pro Arg Met  Arg Ala Met Ser Leu  Val Ser Asn 
    2600                 2605                 2610             


Glu Gly  Glu Gly Glu Gln Asn  Glu Ile Arg Ile Leu  Gln Asp Lys 
    2615                 2620                 2625             


Leu Asn  Ser Thr Met Lys Leu  Val Ser His Leu Thr  Ala Gln Leu 
    2630                 2635                 2640             


Asn Glu  Leu Lys Glu Gln Met  Thr Glu Gln Arg Lys  Arg Arg Gln 
    2645                 2650                 2655             


Arg Leu  Gly Phe Val Asp Val  Gln Asn Cys Ile Ser  Arg 
    2660                 2665                 2670     


<210>  1761
<211>  536
<212>  DNA
<213>  Homosapiens

<400>  1761
gccgactcct cccgctaagg cgggaacacg cggggcccaa gatggcggcc agccggtacc     60

ggcgttttct taagctctgt gaggaatggc cagtggacga gaccaaacgg ggccgggact    120

tgggcgctta cctgcgacag cgggtagcac aggcctttcg ggagggagag aatacccagg    180

ttgcagagcc tgaggcctgt gatcagatgt acgagagctt agcgcgactc cattcaaact    240

actacaaaca caagtaccct cgccccagag acaccagctt cagtggcctg tcgttggaag    300

agtacaagct gatcctgtcc acagacacct tggaagagct taaggaaata gataaaggca    360

tgtggaagaa actgcaggag aagtttgccc ccaagggtcc tgaggaggat cataaggcct    420

gagctcaggc cttacctcgt gcacatacct aggtgtggag tcttgtacat tgccatcgtc    480

aataaaactg ccccagtttc cccttgcaaa aaaaaaaaaa aaaaaaaaaa aaaaaa        536


<210>  1762
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  1762

Met Ala Ala Ser Arg Tyr Arg Arg Phe Leu Lys Leu Cys Glu Glu Trp 
1               5                   10                  15      


Pro Val Asp Glu Thr Lys Arg Gly Arg Asp Leu Gly Ala Tyr Leu Arg 
            20                  25                  30          


Gln Arg Val Ala Gln Ala Phe Arg Glu Gly Glu Asn Thr Gln Val Ala 
        35                  40                  45              


Glu Pro Glu Ala Cys Asp Gln Met Tyr Glu Ser Leu Ala Arg Leu His 
    50                  55                  60                  


Ser Asn Tyr Tyr Lys His Lys Tyr Pro Arg Pro Arg Asp Thr Ser Phe 
65                  70                  75                  80  


Ser Gly Leu Ser Leu Glu Glu Tyr Lys Leu Ile Leu Ser Thr Asp Thr 
                85                  90                  95      


Leu Glu Glu Leu Lys Glu Ile Asp Lys Gly Met Trp Lys Lys Leu Gln 
            100                 105                 110         


Glu Lys Phe Ala Pro Lys Gly Pro Glu Glu Asp His Lys Ala 
        115                 120                 125     


<210>  1763
<211>  2628
<212>  DNA
<213>  Homosapiens

<400>  1763
agacctcccg caccagggct ctggtgaaca gcaaatgctc cacgctggga cgggccattg     60

cctgatgcct gtacatggtg ggcactgaga gacaagattc ctgggccctg ccttccatac    120

actccccacg atctcggagg aagctctgag gaccccgctg agaacccaca gacaggagga    180

caactgcgct atgacagcaa taaaggccaa gaaggagaaa gttgaggacc gctgacagcc    240

ccgtgtgctg ttgggagctg ccctttctac ttcaaacctt cctctagcag actgtgcagg    300

gaccccccac caccaccatc tgccgccatg gttgtgcaaa acagcgcaga cgccggggac    360

atgagggcag gcgtgcagct ggagcccttc ctgcaccagg tcggggggca catgagcgtg    420

atgaagtatg acgagcatac ggtgtgcaag cccctcgtct cccgggagca gaggttctat    480

gaatccctgc cgctggccat gaagcggttc accccacagt acaaaggtac cgtcacagtg    540

cacctctgga aagacagcac aggccatctc agcttggttg ccaacccagt gaaggagagc    600

caggagccct tcaaggtctc cacagagtcg gcggcggtgg ccatatggca gacgctccag    660

cagaccaccg gcagcaatgg cagcgactgc acccttgccc agtggccgca tgcccagctg    720

gcacgctcac ccaaggagag cccggccaag gctcttctga ggtccgagcc ccacctcaac    780

actccagcct tctcgctggt ggaagacacc aacggaaacc aggttgagag gaagagcttc    840

aacccgtggg gcctgcaatg ccaccaggcc cacctgaccc gcctgtgctc cgagtaccca    900

gagaacaagc ggcatcggtt cttgttgctg gaaaatgtag tgtcacagta cacgcatccc    960

tgtgtcctgg atctgaagat ggggacccgg cagcacggcg atgatgcatc ggaggagaag   1020

aaggcccgcc acatgaggaa gtgtgcgcag agcacctcag cctgcctggg tgtgcgcatc   1080

tgcggcatgc aggtttatca aacagataag aagtactttc tctgcaaaga caagtactat   1140

ggaagaaaac tctcagtgga ggggttcaga caagccctct atcagttcct acataatgga   1200

agccacctcc ggagggagct cctggagccc atcctgcacc agctccgggc cctcctctct   1260

gtcattagga gccagagttc ataccgcttc tattccagct ctctccttgt catctatgat   1320

gggcaggaac caccagaaag agccccaggc agcccgcatc ctcacgaggc tccccaggca   1380

gcccacggta gctctcccgg tggtctcacc aaggttgaca tccgcatgat tgactttgct   1440

cataccacat acaagggcta ctggaatgag cacaccacct acgatggacc agaccctggc   1500

tatatttttg gcctggaaaa cctcatcagg atcctgcagg atatccaaga gggagaatga   1560

aacttcctgg gcttatctgg attcttctgg gctatagatc tcaaatagag acctgttggt   1620

tgctagggta gtccagacac cccttagatg tcttcataat agtcctatct accttcaaaa   1680

accatctcta tatatggcag actatattaa cagctgctga acaaatcagc tctggaggtg   1740

attccacatc ccctggcatt atgctctaat gctgctcatc ggagaacaga cagccaggat   1800

aaagtggcac cttctggagt acactggagg gggcagccca agttagaggc cagcattgct   1860

gacattctgg aatatttgca tctaaaaatg tttactcgtt gccatgctgc agtccgcaca   1920

agctgtgagg cagaaaactt gacttgaagc agccttgaag agtgagttca tgagctcatg   1980

gtttttctcc ttgtatggac tgctcgctcc aagggcaggc agagctcatg aatgcctctt   2040

atcttcctaa gcggagtttt aggtgacaca ggatgaagca gaagagatct acccatctca   2100

tctgctctgc acccagcttc taagtggaca aagccaagcc caggcatgag ctctggcaaa   2160

gcaagacccc agattctcca tttttgcctg tggaaaggag ggtcccttta caggcttttt   2220

tttccttttt ttcccccaaa atctcttaaa atgaggaatc tcttagcaga ctttggagtt   2280

ccccattctg ccacattctg accatgagac gcggcttgca gtgggggtga acgcacataa   2340

aaagggacca ctgacgtcct gctctactct ctgctttcta tttatttatt ttgggggtgg   2400

gttggggagt cagaagaacc tggaggacgg aggaaaccag gggcaatgtt tacaagactg   2460

gtggacaagt gtaaatatgg aataagaaca aacagttcta attaattcct tcttctgcag   2520

tatggaaacc tattacgatg cccttgagtc aagcactgag atacgttacc caattaggga   2580

aataaatttg ttaataaaat tgctgaggtc accaaaaaaa aaaaaaaa                2628


<210>  1764
<211>  410
<212>  PRT
<213>  Homosapiens

<400>  1764

Met Val Val Gln Asn Ser Ala Asp Ala Gly Asp Met Arg Ala Gly Val 
1               5                   10                  15      


Gln Leu Glu Pro Phe Leu His Gln Val Gly Gly His Met Ser Val Met 
            20                  25                  30          


Lys Tyr Asp Glu His Thr Val Cys Lys Pro Leu Val Ser Arg Glu Gln 
        35                  40                  45              


Arg Phe Tyr Glu Ser Leu Pro Leu Ala Met Lys Arg Phe Thr Pro Gln 
    50                  55                  60                  


Tyr Lys Gly Thr Val Thr Val His Leu Trp Lys Asp Ser Thr Gly His 
65                  70                  75                  80  


Leu Ser Leu Val Ala Asn Pro Val Lys Glu Ser Gln Glu Pro Phe Lys 
                85                  90                  95      


Val Ser Thr Glu Ser Ala Ala Val Ala Ile Trp Gln Thr Leu Gln Gln 
            100                 105                 110         


Thr Thr Gly Ser Asn Gly Ser Asp Cys Thr Leu Ala Gln Trp Pro His 
        115                 120                 125             


Ala Gln Leu Ala Arg Ser Pro Lys Glu Ser Pro Ala Lys Ala Leu Leu 
    130                 135                 140                 


Arg Ser Glu Pro His Leu Asn Thr Pro Ala Phe Ser Leu Val Glu Asp 
145                 150                 155                 160 


Thr Asn Gly Asn Gln Val Glu Arg Lys Ser Phe Asn Pro Trp Gly Leu 
                165                 170                 175     


Gln Cys His Gln Ala His Leu Thr Arg Leu Cys Ser Glu Tyr Pro Glu 
            180                 185                 190         


Asn Lys Arg His Arg Phe Leu Leu Leu Glu Asn Val Val Ser Gln Tyr 
        195                 200                 205             


Thr His Pro Cys Val Leu Asp Leu Lys Met Gly Thr Arg Gln His Gly 
    210                 215                 220                 


Asp Asp Ala Ser Glu Glu Lys Lys Ala Arg His Met Arg Lys Cys Ala 
225                 230                 235                 240 


Gln Ser Thr Ser Ala Cys Leu Gly Val Arg Ile Cys Gly Met Gln Val 
                245                 250                 255     


Tyr Gln Thr Asp Lys Lys Tyr Phe Leu Cys Lys Asp Lys Tyr Tyr Gly 
            260                 265                 270         


Arg Lys Leu Ser Val Glu Gly Phe Arg Gln Ala Leu Tyr Gln Phe Leu 
        275                 280                 285             


His Asn Gly Ser His Leu Arg Arg Glu Leu Leu Glu Pro Ile Leu His 
    290                 295                 300                 


Gln Leu Arg Ala Leu Leu Ser Val Ile Arg Ser Gln Ser Ser Tyr Arg 
305                 310                 315                 320 


Phe Tyr Ser Ser Ser Leu Leu Val Ile Tyr Asp Gly Gln Glu Pro Pro 
                325                 330                 335     


Glu Arg Ala Pro Gly Ser Pro His Pro His Glu Ala Pro Gln Ala Ala 
            340                 345                 350         


His Gly Ser Ser Pro Gly Gly Leu Thr Lys Val Asp Ile Arg Met Ile 
        355                 360                 365             


Asp Phe Ala His Thr Thr Tyr Lys Gly Tyr Trp Asn Glu His Thr Thr 
    370                 375                 380                 


Tyr Asp Gly Pro Asp Pro Gly Tyr Ile Phe Gly Leu Glu Asn Leu Ile 
385                 390                 395                 400 


Arg Ile Leu Gln Asp Ile Gln Glu Gly Glu 
                405                 410 


<210>  1765
<211>  3005
<212>  DNA
<213>  Homosapiens

<400>  1765
gacgccgccg ccaccgcctc ctcagagcgg ggcccgggcc cagccgccgc caccgctgcc     60

gccgccgagc tccgccgccg ccgagcacca tgggagacgc tgggagcgag cgcagcaaag    120

cgcccagcct gccgcctcgc tgtccctgcg gcttctgggg gtccagcaag actatgaatc    180

tctgttccaa atgctttgct gattttcaaa agaaacagcc agacgatgat tccgctccaa    240

gtacaagtaa cagccaatca gatttgtttt ccgaagagac caccagtgac aacaacaata    300

cctcgataac cacgccaact cttagtccca gccagcagcc gcttccgaca gaactgaatg    360

taacttcacc gagtaaagag gagtgtgggc catgcacaga cacagctcat gtctcattaa    420

tcacaccaac aaaaagatcc tgtggtacag attcacagtc tgagaatgag gcttcaccag    480

taaaacggcc acgactactt gagaatacgg aacggtccga ggaaaccagt cgatctaaac    540

agaagagtcg acgtcggtgc ttccagtgcc aaaccaaact ggagctggtg cagcaggaat    600

tgggatcgtg tcgctgcggt tatgtgttct gtatgttaca tcgcctcccc gagcagcacg    660

actgcacatt cgaccacatg ggccgtggcc gggaggaagc catcatgaaa atggtgaagc    720

tggaccggaa agtggggcgc tcctgccagc gcatcgggga ggggtgctcc tgaaggccag    780

gcatggccac cacgtgacgc tgttcttagt tcactaatgt tagccttatt taggacaaag    840

tcagccagac accttgtact gggcacgcgt cagactgcag ccagtccgtt tcctttcttt    900

agccagccat cctggtactg tagtttaggg gttgatggtg gttgaaattg atttctggct    960

ggttactaag gtgcctgcta gccattgtat aaaattaaaa catgaagaat attttttttt   1020

ttgagcatgg ctagtggatt taaaacaaca catacctgtc actgctggag tcaaacttat   1080

aaaaagcctt aagtggaaag tgttccagac ggagactctg agttaataga ggagtagaag   1140

ctggtgttaa agttcccacg acgcacatgg ctttgccaga aactctgttt aatgatcggc   1200

ctttcacctc ttcacttatc cttagtccca gtagccagga tacctgatgg ccacgtgtgc   1260

cttggccacg ggaggctgct gagattggcc acgtggctgg actgggtggt ggcctcactc   1320

tcccacagag ctggaaatgg ggggtggggg acagattctt acggaaattt ttttacctga   1380

cttgctatga aaaaactcat cacacaagaa gagaaacagt aacctcactt tgaaaattag   1440

ctccactcaa gactagtcca cgaacgagac ccgccttttc tacacaggat ccaaggtcac   1500

gagaagcagc cagagtgccc cgcctccgcc ggctctggtc tgccattcgc cagtgcaggg   1560

atctggcacg gaccagatgt ggcgaatggc agcacagcgc ggtggctggg tctgcacact   1620

ggcctctgca gccagatttc tatattggga gttttttaaa aagacatttc atagccaaca   1680

agaatcagta gaagtgctgg gagcagcagc tggggaagct gccgcccacg ggctctgccc   1740

cttccagctg gagccgcccg tgcctccagg ggccaagagg atgatgtcgt ggcctccatt   1800

ctcgtttcta tgcagcccca tagtccaagg acacccagtc cacatctacc atatagcaag   1860

tttagtaagg gaaggcagca tacgtcccag ggacagtggg tttggatctg tctagaacag   1920

cggtttgtgg ctgtggccca gctccgagag tgatatttgc tctggtaggt gagggcctga   1980

gggtacattt ctccacctgt gccccctcat gttcacagag gatttcagca gctgcaactg   2040

cgcacgccag gtggggaagg gtgggggtgg gcctggttgc cccatgttag gaaatcacta   2100

ccagtcaggt ggggctgggg ctgggtggac aggatcagga ttcccttgaa agcccaggca   2160

gggtgagcag tcccagtggt cctagtgccg catcagatcc aggtgggtga gggcaggagg   2220

cccctgcgaa ggcagcgtgg atctgcccac acataggcta ctggaatagt ttaacccagc   2280

aactttcctt tttataaaac aacaaatggt tcaactctgt ctgcaaatta acagctgaac   2340

acctgcaact gcaaatgttt tttgatccga cgtactgaaa taggaagtca tgctcttccc   2400

accctccacc caccagagtg gaacccgctg caaaatcccc agccttaatt cttgcttcag   2460

gacccagacc ggtgtcttgc tctagggcaa cccagggcag aggggccagg tctgcccagc   2520

gtttaccact gctgtcaagc cacagccctt ggccaccata cgggccatcc tcagtgaggc   2580

agccccccat aggcttccgc caagctctgg tcccgaagag gctgtgcgag cccttcccgg   2640

ccctccccag ggccccccgc cccctcctct gcctgctgcg tggaggcagc catgggaagg   2700

agcccagggg agctggcctg ggggagcgaa gcccatgttc gcttcctgac ttagagctgg   2760

ggggggtggg gggtggggct tgttcccctg cagtatctgt tctgtgaagt ttgttaaatg   2820

taaggaaagc ttaaattctt gtatctttaa aagagaaaat cttatttaac ccttttgtgt   2880

tctagattta cttacacaca tagcctagag ctcagtttta gttttaacat tgtgaaaata   2940

ttaaaagaat cttgtaactt tattcttttt tctcctgctg aaaaaaaaat taaaccaatc   3000

gtatg                                                               3005


<210>  1766
<211>  227
<212>  PRT
<213>  Homosapiens

<400>  1766

Met Gly Asp Ala Gly Ser Glu Arg Ser Lys Ala Pro Ser Leu Pro Pro 
1               5                   10                  15      


Arg Cys Pro Cys Gly Phe Trp Gly Ser Ser Lys Thr Met Asn Leu Cys 
            20                  25                  30          


Ser Lys Cys Phe Ala Asp Phe Gln Lys Lys Gln Pro Asp Asp Asp Ser 
        35                  40                  45              


Ala Pro Ser Thr Ser Asn Ser Gln Ser Asp Leu Phe Ser Glu Glu Thr 
    50                  55                  60                  


Thr Ser Asp Asn Asn Asn Thr Ser Ile Thr Thr Pro Thr Leu Ser Pro 
65                  70                  75                  80  


Ser Gln Gln Pro Leu Pro Thr Glu Leu Asn Val Thr Ser Pro Ser Lys 
                85                  90                  95      


Glu Glu Cys Gly Pro Cys Thr Asp Thr Ala His Val Ser Leu Ile Thr 
            100                 105                 110         


Pro Thr Lys Arg Ser Cys Gly Thr Asp Ser Gln Ser Glu Asn Glu Ala 
        115                 120                 125             


Ser Pro Val Lys Arg Pro Arg Leu Leu Glu Asn Thr Glu Arg Ser Glu 
    130                 135                 140                 


Glu Thr Ser Arg Ser Lys Gln Lys Ser Arg Arg Arg Cys Phe Gln Cys 
145                 150                 155                 160 


Gln Thr Lys Leu Glu Leu Val Gln Gln Glu Leu Gly Ser Cys Arg Cys 
                165                 170                 175     


Gly Tyr Val Phe Cys Met Leu His Arg Leu Pro Glu Gln His Asp Cys 
            180                 185                 190         


Thr Phe Asp His Met Gly Arg Gly Arg Glu Glu Ala Ile Met Lys Met 
        195                 200                 205             


Val Lys Leu Asp Arg Lys Val Gly Arg Ser Cys Gln Arg Ile Gly Glu 
    210                 215                 220                 


Gly Cys Ser 
225         


<210>  1767
<211>  1980
<212>  DNA
<213>  Homosapiens

<400>  1767
agataaggaa ttgtatagga ggaaacttca tagtaaacat tgaacctctg tgcttgtctc     60

cttgttgaag ttgggggttc atgtttattg ttccaaggga gcctcatcaa aaccactttt    120

aaagcattga gaatccaaat aaataccatg gatcatacag gattggggat aagtcttgag    180

gtctccccga gaaggagaag ttctttaatt tggtaatttt agggtaatgg ttggatgctc    240

tctggattaa tggaaacctt caggggtact tttaggcaga gtataaccca gtgaagagag    300

cattattata tggtggaatg cgagagtctc agcctgaagc agaaattcct ctccaagaca    360

ccactgcaga agcattcaca atgctactca aatatatcta cactgggcgg gcaacgctga    420

cagatgagaa ggaggaggtg ctgctggact ttttgagcct ggctcataaa tatggatttc    480

cagagctaga ggattctacc tctgagtatc tctgcaccat acttaacatt cagaatgtct    540

gcatgacttt tgatgttgcc agtctctact cacttcccaa gttaacttgt atgtgctgca    600

tgtttatgga taggaatgct caggaagtcc tctcaagtga aggtttcctc tccctttcta    660

agacagcact tttaaacatc gtgttaagag actcatttgc agctcccgaa aaagatattt    720

tcctagcctt attaaactgg tgtaagcaca attcaaagga gaatcatgct gaaatcatgc    780

aggctgtgcg tttacctctc atgagcctca cagagcttct gaatgttgtg aggccttcag    840

gactgctgtc tcctgatgcc atcctggatg ccattaaagt gcgatctgag agccgggata    900

tggacctcaa ttatagaggc atgctcatac cagaagaaaa cattgcaact atgaagtatg    960

gagcccaagt tgtaaagggg gagctgaaat cagccttatt agatggtgat actcaaaatt   1020

atgatttgga tcatggattt tcaaggcacc caattgatga tgactgccgt tccggcatcg   1080

agattaagct aggtcagcca tccgttatca atcacatacg gatactcttg tgggaccgag   1140

atagccggtc ttactcatac ttcattgaag tgtcaatgga tgaacttgat tgggtcagag   1200

tgatagatca ttcacaatat ctgtgtcgtt cttggcagaa attatatttt ccagcccgtg   1260

tctgcaggta tattcgaatt gttgggactc acaacacagt gaacaagatt tttcacattg   1320

tggcttttga atgtatgttt acaaacaaaa ccttcactct tgagaagggg ctgatagttc   1380

ccatggagaa tgttgcaaca attgctgatt gtgccagtgt gattgaagga gtcagtcgga   1440

gccgaaatgc cttgctgaat ggggacacta agaattatga ctgggattct ggctacacat   1500

gtcaccagct aggaagtggt gcgattgtgg ttcagttggc acaaccgtac atgattgggt   1560

caatacggtt actactttgg gattgtgatg atcgaagcta tagctactac gttgaggttt   1620

ctaccaacca gcaacagtgg accatggttg ctgacagaac taaagtctcc tgcaagtcct   1680

ggcagtcagt aacttttgaa aggcagcctg cctccttcat ccgtatcgtt gggacacaca   1740

acacagcaaa tgaggtgttc cactgtgtcc actttgagtg tccagagcag cagagcagcc   1800

agaaggagga aaatagtgag gaatcgggga caggggacac cagcctggcc ggtcagcagc   1860

tcgactccca tgcgctgcgg gcgcctagtg gcagctcact accctccagc ccaggctcca   1920

actcacgctc ccccaaccgg cagcaccaat aaaggaggca gcgggcctgg tgtgacttgg   1980


<210>  1768
<211>  544
<212>  PRT
<213>  Homosapiens

<400>  1768

Met Arg Glu Ser Gln Pro Glu Ala Glu Ile Pro Leu Gln Asp Thr Thr 
1               5                   10                  15      


Ala Glu Ala Phe Thr Met Leu Leu Lys Tyr Ile Tyr Thr Gly Arg Ala 
            20                  25                  30          


Thr Leu Thr Asp Glu Lys Glu Glu Val Leu Leu Asp Phe Leu Ser Leu 
        35                  40                  45              


Ala His Lys Tyr Gly Phe Pro Glu Leu Glu Asp Ser Thr Ser Glu Tyr 
    50                  55                  60                  


Leu Cys Thr Ile Leu Asn Ile Gln Asn Val Cys Met Thr Phe Asp Val 
65                  70                  75                  80  


Ala Ser Leu Tyr Ser Leu Pro Lys Leu Thr Cys Met Cys Cys Met Phe 
                85                  90                  95      


Met Asp Arg Asn Ala Gln Glu Val Leu Ser Ser Glu Gly Phe Leu Ser 
            100                 105                 110         


Leu Ser Lys Thr Ala Leu Leu Asn Ile Val Leu Arg Asp Ser Phe Ala 
        115                 120                 125             


Ala Pro Glu Lys Asp Ile Phe Leu Ala Leu Leu Asn Trp Cys Lys His 
    130                 135                 140                 


Asn Ser Lys Glu Asn His Ala Glu Ile Met Gln Ala Val Arg Leu Pro 
145                 150                 155                 160 


Leu Met Ser Leu Thr Glu Leu Leu Asn Val Val Arg Pro Ser Gly Leu 
                165                 170                 175     


Leu Ser Pro Asp Ala Ile Leu Asp Ala Ile Lys Val Arg Ser Glu Ser 
            180                 185                 190         


Arg Asp Met Asp Leu Asn Tyr Arg Gly Met Leu Ile Pro Glu Glu Asn 
        195                 200                 205             


Ile Ala Thr Met Lys Tyr Gly Ala Gln Val Val Lys Gly Glu Leu Lys 
    210                 215                 220                 


Ser Ala Leu Leu Asp Gly Asp Thr Gln Asn Tyr Asp Leu Asp His Gly 
225                 230                 235                 240 


Phe Ser Arg His Pro Ile Asp Asp Asp Cys Arg Ser Gly Ile Glu Ile 
                245                 250                 255     


Lys Leu Gly Gln Pro Ser Val Ile Asn His Ile Arg Ile Leu Leu Trp 
            260                 265                 270         


Asp Arg Asp Ser Arg Ser Tyr Ser Tyr Phe Ile Glu Val Ser Met Asp 
        275                 280                 285             


Glu Leu Asp Trp Val Arg Val Ile Asp His Ser Gln Tyr Leu Cys Arg 
    290                 295                 300                 


Ser Trp Gln Lys Leu Tyr Phe Pro Ala Arg Val Cys Arg Tyr Ile Arg 
305                 310                 315                 320 


Ile Val Gly Thr His Asn Thr Val Asn Lys Ile Phe His Ile Val Ala 
                325                 330                 335     


Phe Glu Cys Met Phe Thr Asn Lys Thr Phe Thr Leu Glu Lys Gly Leu 
            340                 345                 350         


Ile Val Pro Met Glu Asn Val Ala Thr Ile Ala Asp Cys Ala Ser Val 
        355                 360                 365             


Ile Glu Gly Val Ser Arg Ser Arg Asn Ala Leu Leu Asn Gly Asp Thr 
    370                 375                 380                 


Lys Asn Tyr Asp Trp Asp Ser Gly Tyr Thr Cys His Gln Leu Gly Ser 
385                 390                 395                 400 


Gly Ala Ile Val Val Gln Leu Ala Gln Pro Tyr Met Ile Gly Ser Ile 
                405                 410                 415     


Arg Leu Leu Leu Trp Asp Cys Asp Asp Arg Ser Tyr Ser Tyr Tyr Val 
            420                 425                 430         


Glu Val Ser Thr Asn Gln Gln Gln Trp Thr Met Val Ala Asp Arg Thr 
        435                 440                 445             


Lys Val Ser Cys Lys Ser Trp Gln Ser Val Thr Phe Glu Arg Gln Pro 
    450                 455                 460                 


Ala Ser Phe Ile Arg Ile Val Gly Thr His Asn Thr Ala Asn Glu Val 
465                 470                 475                 480 


Phe His Cys Val His Phe Glu Cys Pro Glu Gln Gln Ser Ser Gln Lys 
                485                 490                 495     


Glu Glu Asn Ser Glu Glu Ser Gly Thr Gly Asp Thr Ser Leu Ala Gly 
            500                 505                 510         


Gln Gln Leu Asp Ser His Ala Leu Arg Ala Pro Ser Gly Ser Ser Leu 
        515                 520                 525             


Pro Ser Ser Pro Gly Ser Asn Ser Arg Ser Pro Asn Arg Gln His Gln 
    530                 535                 540                 


<210>  1769
<211>  2478
<212>  DNA
<213>  Homosapiens

<400>  1769
gtatttccgg agtcccttct gagacagaag gttgtgttgg ggaactgaag gagtttctgt     60

gggcggacag ggaaccctgc gtttctactg tgtgattctg ccaccttcct ggcccgacgc    120

catgggagtg acttgtgtgt cccagatgcc tgtggccgag ggcaagagtg ttcagcaaac    180

cgtagagctc cttacccgga aattggagat gcttggggca gagaagcaag gaacattttg    240

tgtggactgt gagacttacc atacggccgc ctctaccctt ggcagccaag gtcagaccgg    300

gaagctgatg tatgtgatgc acaactcaga gtacccattg agctgtttcg ccctctttga    360

gaatggccct tgccttattg ctgacaccaa ctttgatgtg cttatggtga agctcaaggg    420

ctttttccag agtgctaagg ccagcaagat tgagacccgg ggcaccaggt accagtactg    480

tgacttcctg gtgaaggtgg gcacggtcac aatggggccc agtgcccggg gcatctctgt    540

ggaggtggag tatggcccct gtgtggtagc tagtgactgc tggagtctgc tgctcgagtt    600

cctacagagt tttctaggca gccacacacc aggggctccc gcagtgtttg ggaacagaca    660

tgatgcggtc tacggcccag cagataccat ggtccagtac atggaactct tcaacaagat    720

ccgcaagcag cagcaggtgc cggtggctgg gattcgttag tgatgagcag ctgccagctg    780

agctctgtca ccaggggtac tccacaggag gagcaggtgc tgactttcag gtccctggac    840

cccagaaacc cagggtagac atggactcta ctctccttct ctggttctca gctgtggctt    900

ttgttctggg gctgagtccc ctccccaacc ccctgactct cacacatagc cccccatcag    960

ctgttttact ccgtgcctta ctggatttgg cctgtcctca agaatggtaa ttatgaagag   1020

tggagaagtt tggaccttgc ctcctttagg ggaaaggtag gacaggaatg tccctgcctg   1080

gtactggtgg gggaaatagt ccgtatcccc aactattaag gatttgtccc aggccaatgg   1140

tgaacatgct gcattttatg tttggattgt gctgtaataa gagcctcttc cttccctcag   1200

aggatgtggc tgggcttcta tcctagagat ggagtagaag gcacaactgg tttgatagtt   1260

actattttct gacctgtttg ctgaagtgat ttgcgaattg actttcctag ggtgttgcct   1320

gagtcctttg aaatctcctt ctgacatctt tcccttctgt tgtgaaatat gttaagccac   1380

aggccaaact gctataagat cgaagtttgt ttttttctca cctaataata gagaggtaat   1440

cagatggtct agggcagatt taactctaca aggttatcag gaactttgtt tccttctgtc   1500

ttattcagcc attcccagta tgttttctta cccataagat caaagcagac tcatcagctc   1560

catatctgca ttccactggg gaaagagaga gagaaaagag cagattttaa aaaaaagata   1620

tgactgagca ttgctcagat cactgtggcc acactttgct gaaagagatg ctgggacata   1680

gaacctctta tctgggcagt catgtgctga gttaaaactc agggattctg tgactacaag   1740

atgaaagaca atttggttgc tgagatgcag ttaatggctt ctgttacatg gagctcaatg   1800

gacgtgccca ggaatgcttt tggctgttat tttgcagtta atacctcctg taactaaagc   1860

atttgtttat gagttgactt gagagaaggg ctgatctcag agccgctttg agctaagttg   1920

gattagtcac actaggaagt taattccaca cctttcgtct aagtctcagt attgaggcct   1980

ctccagttct catgcaccct gatcttaggg ttagaatact tgaccctgat acctgcacca   2040

tgcttcatgg ttcctgagct ctttctcctg tttcatttga gcctccaaac tacatatttg   2100

gtcatattgc ctgcctaccc catgcctgct gcagaaatat tcatccaggt taaccttgat   2160

atacacagag atggtcttgg agaattgtga atgtatgtac tgtattgtca tcaaggatac   2220

tgtcccttat ttgaaggcat ctaaagagaa actgttttca gatccaagtg ctcagatcta   2280

aagcctctgc aacaagtcag gtggtggtca tgtttccctt ctagttttgg ctgacaggaa   2340

gctcagttca gtaccataac tacagaacct gtcatctgta ttttttgttc tcaccccgtt   2400

tttgttattt tgtttctggt tttttatatt gaggtatgtt ttagatatag tttacaaaaa   2460

taaaacgcac agatctta                                                 2478


<210>  1770
<211>  212
<212>  PRT
<213>  Homosapiens

<400>  1770

Met Gly Val Thr Cys Val Ser Gln Met Pro Val Ala Glu Gly Lys Ser 
1               5                   10                  15      


Val Gln Gln Thr Val Glu Leu Leu Thr Arg Lys Leu Glu Met Leu Gly 
            20                  25                  30          


Ala Glu Lys Gln Gly Thr Phe Cys Val Asp Cys Glu Thr Tyr His Thr 
        35                  40                  45              


Ala Ala Ser Thr Leu Gly Ser Gln Gly Gln Thr Gly Lys Leu Met Tyr 
    50                  55                  60                  


Val Met His Asn Ser Glu Tyr Pro Leu Ser Cys Phe Ala Leu Phe Glu 
65                  70                  75                  80  


Asn Gly Pro Cys Leu Ile Ala Asp Thr Asn Phe Asp Val Leu Met Val 
                85                  90                  95      


Lys Leu Lys Gly Phe Phe Gln Ser Ala Lys Ala Ser Lys Ile Glu Thr 
            100                 105                 110         


Arg Gly Thr Arg Tyr Gln Tyr Cys Asp Phe Leu Val Lys Val Gly Thr 
        115                 120                 125             


Val Thr Met Gly Pro Ser Ala Arg Gly Ile Ser Val Glu Val Glu Tyr 
    130                 135                 140                 


Gly Pro Cys Val Val Ala Ser Asp Cys Trp Ser Leu Leu Leu Glu Phe 
145                 150                 155                 160 


Leu Gln Ser Phe Leu Gly Ser His Thr Pro Gly Ala Pro Ala Val Phe 
                165                 170                 175     


Gly Asn Arg His Asp Ala Val Tyr Gly Pro Ala Asp Thr Met Val Gln 
            180                 185                 190         


Tyr Met Glu Leu Phe Asn Lys Ile Arg Lys Gln Gln Gln Val Pro Val 
        195                 200                 205             


Ala Gly Ile Arg 
    210         


<210>  1771
<211>  2005
<212>  DNA
<213>  Homosapiens

<400>  1771
gcggattccc gccccgaggt ttctaaatcc agacattccc gtttggctga gcactctagg     60

cctacatcca tgaagctagg agagcgacac tcaaagactg cactattgag agaagctaac    120

gttaaaggca gtgaatatat tcgggagtcc agctccggaa cccgggagct cttttagtgg    180

gaggggcggc gctgatggcg cttctggcct ccgaatgcta gggggcgctg tgatcgccgg    240

gcggcctctt gggcgctggg agtccaccgc gcaagcgcat cctggccttt cttcagtccc    300

cacgtgcgat ccttcccggc aactttttcg agaaaaatgc ccaaattcaa ggcggcccgt    360

ggggtggggg gtcaggaaaa acatgcgccc ctggccgatc agatcctggc tgggaatgcg    420

gtgcgggcgg gggtccggga gaagcggcgg ggtcgcggga caggagaagc ggaggaagag    480

tatgtggggc cccggctgag ccgacggatt ttgcagcaag cacggcagca acaggaggaa    540

ctcgaggccg agcatgggac tggggacaag cccgcggcgc cgcgggaacg caccacgcgg    600

ctgggtccaa gaatgcctca ggatggatca gatgacgagg acgaggagtg gcccaccctg    660

gagaaggctg ccacaatgac agcagcgggc catcatgcag aggtggttgt ggaccctgag    720

gatgagcgtg ccatagagat gttcatgaac aagaaccctc ctgccaggcg caccctggct    780

gacatcatca tggagaagct gactgagaag cagacagagg ttgagacagt catgtcagag    840

gtgtcgggct tccctatgcc ccagctggac ccccgggtcc tagaagtgta caggggggtc    900

cgggaggtat tatctaagta ccgcagtgga aaactgccca aggcatttaa gatcatccct    960

gcactctcca actgggagca aatcctctac gtcacagagc cggaggcctg gactgcagct   1020

gccatgtacc aggccaccag gatttttgcc tctaacctga aggaacgcat ggcccagcgc   1080

ttctacaacc ttgtcctgct ccctcgagta cgagatgacg ttgctgaata caaacgactc   1140

aacttccatc tctacatggc tctcaagaag gcccttttca aacctggagc ctggttcaaa   1200

gggatcctga ttccactgtg cgagtctggc acttgtaccc tccgggaagc catcattgtg   1260

ggtagcatca tcaccaagtg ctccatccct gtgttgcact ccagtgcggc catgctgaaa   1320

attgctgaga tggaatacag cggtgccaac agcatcttcc tgcgactgct gctggataag   1380

aagtatgcac tgccttaccg ggtgctggat gccctagtct tccacttcct ggggttccgg   1440

acagagaagc gtgaactgcc tgtgctgtgg caccagtgcc tcctgacttt ggtccagcgc   1500

tacaaggccg acttggccac agaccagaaa gaggccctct tagaactgct ccggctgcag   1560

ccccatccac agctatcgcc cgaaatcagg cgtgagcttc agagtgcagt cccccgcgat   1620

gtggaagatg ttcccatcac cgtggagtga ggaaaacagt cagctgtcct ggccaaaggg   1680

gtttggaagg acaccaagac ccccgttggt gactgaagat gacactgagc tttaatggct   1740

gaagacccag atcagggcag tgacagatca cagggacatc tgtggctccc agtccaggac   1800

aggaaggact gagggtctgg ctggttccct cttccattct aggcccttat ccctgtttag   1860

ttctgagagc caacttgaga taccatatgc tagcattccc agtccccagc tggggcttgg   1920

tgtgagtact ttttctatgg ctattgtgtc aggtcactgt ggataaaggc aaagacagat   1980

atttattgaa aaaaaaaaaa aaaaa                                         2005


<210>  1772
<211>  437
<212>  PRT
<213>  Homosapiens

<400>  1772

Met Pro Lys Phe Lys Ala Ala Arg Gly Val Gly Gly Gln Glu Lys His 
1               5                   10                  15      


Ala Pro Leu Ala Asp Gln Ile Leu Ala Gly Asn Ala Val Arg Ala Gly 
            20                  25                  30          


Val Arg Glu Lys Arg Arg Gly Arg Gly Thr Gly Glu Ala Glu Glu Glu 
        35                  40                  45              


Tyr Val Gly Pro Arg Leu Ser Arg Arg Ile Leu Gln Gln Ala Arg Gln 
    50                  55                  60                  


Gln Gln Glu Glu Leu Glu Ala Glu His Gly Thr Gly Asp Lys Pro Ala 
65                  70                  75                  80  


Ala Pro Arg Glu Arg Thr Thr Arg Leu Gly Pro Arg Met Pro Gln Asp 
                85                  90                  95      


Gly Ser Asp Asp Glu Asp Glu Glu Trp Pro Thr Leu Glu Lys Ala Ala 
            100                 105                 110         


Thr Met Thr Ala Ala Gly His His Ala Glu Val Val Val Asp Pro Glu 
        115                 120                 125             


Asp Glu Arg Ala Ile Glu Met Phe Met Asn Lys Asn Pro Pro Ala Arg 
    130                 135                 140                 


Arg Thr Leu Ala Asp Ile Ile Met Glu Lys Leu Thr Glu Lys Gln Thr 
145                 150                 155                 160 


Glu Val Glu Thr Val Met Ser Glu Val Ser Gly Phe Pro Met Pro Gln 
                165                 170                 175     


Leu Asp Pro Arg Val Leu Glu Val Tyr Arg Gly Val Arg Glu Val Leu 
            180                 185                 190         


Ser Lys Tyr Arg Ser Gly Lys Leu Pro Lys Ala Phe Lys Ile Ile Pro 
        195                 200                 205             


Ala Leu Ser Asn Trp Glu Gln Ile Leu Tyr Val Thr Glu Pro Glu Ala 
    210                 215                 220                 


Trp Thr Ala Ala Ala Met Tyr Gln Ala Thr Arg Ile Phe Ala Ser Asn 
225                 230                 235                 240 


Leu Lys Glu Arg Met Ala Gln Arg Phe Tyr Asn Leu Val Leu Leu Pro 
                245                 250                 255     


Arg Val Arg Asp Asp Val Ala Glu Tyr Lys Arg Leu Asn Phe His Leu 
            260                 265                 270         


Tyr Met Ala Leu Lys Lys Ala Leu Phe Lys Pro Gly Ala Trp Phe Lys 
        275                 280                 285             


Gly Ile Leu Ile Pro Leu Cys Glu Ser Gly Thr Cys Thr Leu Arg Glu 
    290                 295                 300                 


Ala Ile Ile Val Gly Ser Ile Ile Thr Lys Cys Ser Ile Pro Val Leu 
305                 310                 315                 320 


His Ser Ser Ala Ala Met Leu Lys Ile Ala Glu Met Glu Tyr Ser Gly 
                325                 330                 335     


Ala Asn Ser Ile Phe Leu Arg Leu Leu Leu Asp Lys Lys Tyr Ala Leu 
            340                 345                 350         


Pro Tyr Arg Val Leu Asp Ala Leu Val Phe His Phe Leu Gly Phe Arg 
        355                 360                 365             


Thr Glu Lys Arg Glu Leu Pro Val Leu Trp His Gln Cys Leu Leu Thr 
    370                 375                 380                 


Leu Val Gln Arg Tyr Lys Ala Asp Leu Ala Thr Asp Gln Lys Glu Ala 
385                 390                 395                 400 


Leu Leu Glu Leu Leu Arg Leu Gln Pro His Pro Gln Leu Ser Pro Glu 
                405                 410                 415     


Ile Arg Arg Glu Leu Gln Ser Ala Val Pro Arg Asp Val Glu Asp Val 
            420                 425                 430         


Pro Ile Thr Val Glu 
        435         


<210>  1773
<211>  2095
<212>  DNA
<213>  Homosapiens

<400>  1773
gcgcctgtca gggaagcggc gcgcgcgcgc gggcggcggg cgggctgggg atccgccgcg     60

cagtgccagc gccagcgcca gacccgcgcc ccgcgctctc cggcccgtcg cctgccttgg    120

gactcgcgag cccgcactcc cgccctgcct gttcgctgcc cgagtatgga gctgctgtgt    180

tgcgaaggca cccggcacgc gccccgggcc gggccggacc cgcggctgct gggggaccag    240

cgtgtcctgc agagcctgct ccgcctggag gagcgctacg taccccgcgc ctcctacttc    300

cagtgcgtgc agcgggagat caagccgcac atgcggaaga tgctggctta ctggatgctg    360

gaggtatgtg aggagcagcg ctgtgaggag gaagtcttcc ccctggccat gaactacctg    420

gatcgctacc tgtcttgcgt ccccacccga aaggcgcagt tgcagctcct gggtgcggtc    480

tgcatgctgc tggcctccaa gctgcgcgag accacgcccc tgaccatcga aaaactgtgc    540

atctacaccg accacgctgt ctctccccgc cagttgcggg actgggaggt gctggtccta    600

gggaagctca agtgggacct ggctgctgtg attgcacatg atttcctggc cttcattctg    660

caccggctct ctctgccccg tgaccgacag gccttggtca aaaagcatgc ccagaccttt    720

ttggccctct gtgctacaga ttataccttt gccatgtacc cgccatccat gatcgccacg    780

ggcagcattg gggctgcagt gcaaggcctg ggtgcctgct ccatgtccgg ggatgagctc    840

acagagctgc tggcagggat cactggcact gaagtggact gcctgcgggc ctgtcaggag    900

cagatcgaag ctgcactcag ggagagcctc agggaagcct ctcagaccag ctccagccca    960

gcgcccaaag ccccccgggg ctccagcagc caagggccca gccagaccag cactcctaca   1020

gatgtcacag ccatacacct gtagccctgg agaggccctc tggagtggcc actaagcaga   1080

ggaggggccg ctgccaccca cctccctgcc tccaggaacc acaccacatc taagcctgaa   1140

ggggcgtctg ttcccccttc acaaagccca agggatctgg tcctacccat ccccgcagtg   1200

tgcactaagg ggcccggcca gccatgtctg catttcggtg gctagtcaag ctcctcctcc   1260

ctgcatctga ccagcagcgc ctttcccaac tctagctggg ggtgggccag gctgatggga   1320

cagaattgga tacatacacc agcattcctt ttgaacgccc ccccccaccc ctgggggctc   1380

tcatgttttc aactgccaaa atgctctagt gccttctaaa ggtgttgtcc cttctagggt   1440

tattgcattt ggattggggt ccctctaaaa tttaatgcat gatagacaca tatgaggggg   1500

aatagtctag atggctcctc tcagtacttt ggaggcccct atgtagtccg tgctgacagc   1560

tgctcctaga gggaggggcc taggcctcag ccagagaagc tataaattcc tctttgcttt   1620

gctttctgct cagcttctcc tgtgtgattg acagctttgc tgctgaaggc tcattttaat   1680

ttattaattg ctttgagcac aactttaaga ggacataatg ggggcctggc catcccacaa   1740

gtggtggtaa ccctggtggt tgctgttttc ctcccttctg ctactggcaa aaggatcttt   1800

gtggccaagg agctgctata gcctggggtg gggtcatgcc ctcctctccc attgtccctc   1860

tgccccatcc tccagcaggg aaaatgcagc agggatgccc tggaggtggc tgagcccctg   1920

tctagagagg gaggcaagcc ctgttgacac aggtctttcc taaggctgca aggtttaggc   1980

tggtggccca ggaccatcat cctactgtaa taaagatgat tgtgaaataa aactggcttt   2040

ggcttcttgg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa        2095


<210>  1774
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  1774

Met Glu Leu Leu Cys Cys Glu Gly Thr Arg His Ala Pro Arg Ala Gly 
1               5                   10                  15      


Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu 
            20                  25                  30          


Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln Cys Val 
        35                  40                  45              


Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys 
                85                  90                  95      


Ala Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys 
            100                 105                 110         


Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val 
    130                 135                 140                 


Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe 
145                 150                 155                 160 


Leu Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala 
                165                 170                 175     


Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile 
        195                 200                 205             


Gly Ala Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu 
    210                 215                 220                 


Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu 
225                 230                 235                 240 


Arg Ala Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg 
                245                 250                 255     


Glu Ala Ser Gln Thr Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly 
            260                 265                 270         


Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val Thr 
        275                 280                 285             


Ala Ile His Leu 
    290         


<210>  1775
<211>  4323
<212>  DNA
<213>  Homosapiens

<400>  1775
cgcgctcgcg cacactacgc cagaacaaga tggccgacgc ggcggccaca gctggggccg     60

gtggctccgg aacgagatcg ggaagtaaac agtccactaa ccctgccgat aactatcatc    120

tggcccggag gagaaccctg caggtggttg tgagctcctt gctgacagag gcagggtttg    180

agagtgccga gaaagcatcc gtggaaacgc tgacagagat gctgcagagc tacatttcag    240

aaattgggag aagtgccaag tcttactgtg agcacacagc caggacccag cccacactgt    300

ccgatatcgt ggtcacactt gttgagatgg gtttcaatgt ggacactctc cctgcttatg    360

caaaacggtc tcagaggatg gtcatcactg ctcctccggt gaccaatcag ccagtgaccc    420

ccaaggccct cactgcaggg cagaaccgac cccacccgcc gcacatcccc agccattttc    480

ctgagttccc tgatccccac acctacatca aaactccgac gtaccgtgag cccgtgtcag    540

actaccaggt cctgcgggag aaggctgcat cccagaggcg cgatgtggag cgggcactta    600

cccgtttcat ggccaagaca ggcgagactc agagtctttt caaagatgac gtcagcacat    660

ttccattgat tgctgccaga cctttcacca tcccctacct gacagctctt cttccgtctg    720

aactggagat gcaacaaatg gaagagacag attcctcgga gcaggatgaa cagacagaca    780

cagagaacct tgctcttcat atcagcatgg aggattctgg agccgagaag gagaacacct    840

ctgtcctgca gcagaacccc tccttgtcgg gtagccggaa tggggaggag aacatcatcg    900

ataaccctta tctgcggccg gtgaagaagc ccaagatccg caggaagaag tccctctcct    960

gagctgagaa ggaaacctgg cttgtacagg ggcgcagatt ccaccctccc ggggagttaa   1020

agccactcaa gggaagaaga gggtgacctc ctcatggcca agccgaggct gcagggtgtg   1080

atcggacatg attttcatgg caaaccgtct tattaagatg acctattttc actggatgtt   1140

tgggttgagg aagatatgaa cagaataatg agaatttttt tttttatttt gagatggagt   1200

cttactctat cacccaggct ggaatgcagt ggtgtgatct cagctcactg cagtctcagc   1260

aaccctgggt ccaagtgatt ctcctgcctt ggcctcccga gtagctggga ctagaggcaa   1320

gcgccaccat gctggctaat ttttgtattt tgagtagaga tagggtttcg ccatgttggc   1380

caggctggtc ttgaactcct gacctcaagt gatccacccg cattggcctc ccaaagagtt   1440

gcgattacag gtgtgagcca ccacgcccag ctaatttttg tatttttaat agagataagg   1500

tttcgccatg ttggccaggc tggtcttgaa ctcctgacct caagtgataa cccgcctcgg   1560

cctcccaaag tgctgagatt acaggcgtga gccaccgcac cccaccagag actttcttaa   1620

tcaatcaggc tatgtggtgg ggcatagcag cagccagtga cttcgttcat tatcacagga   1680

tttgattcct ttgaaactca agagaccagg gaaagtgaca ggaaggaaag ggctctttgc   1740

tgctgtgctt attacaagga agactgtttg tccagcgtgt atttcaggat atctggatcc   1800

cttttattga ctcacaattt gtggcaccac tttctcatcc cagaacttca ttcttatttc   1860

tctcctcatc tggcctccca agtgctccgt tgagctgatg aaaagttctt tgtactccct   1920

caacgtgtcg gaaacaggag gccacacagc acagctttgt ttggggtggg caggagtcag   1980

gagtcttgag cagatgcatc actgtgaaga agaacgacat gtcggggctg cacctgtcct   2040

cccgtcggca tttgacgaaa gctccctgaa gcggggcagc actctcctcc tgagagattt   2100

accatttatt gcccctgtga ggaatgtgtg cttgggaact gccaagtctt accccttctg   2160

gaagaagagg ttttctctga caagagccta gagcgtcggc tctattatgc tgggacttga   2220

cagaggagcc atggggttta aacagtagga aagaggggct acgcgcagtg gctcacgcct   2280

gtaatcccag cacttcggga ggcgaaggca ggtggatcac ttgaggtcag gagttcgaga   2340

ccagcctggc caacatagtg aaaccccgtc tctactaaaa atacaaaaat tagccgggtg   2400

tggttactca tgcctgtaat cccagctact cgggaggctg aggcaggaga atcacttgaa   2460

cctgggaggc ggaggttgca gtgagccgag atcgtgccac tgcactccag cctgggtgac   2520

agagcgagac tccatttcaa aaaaataaaa aaaggataaa gtaaacaata ggaaaggatt   2580

tggtggggtg agggtggggt gttgagggct gggcctcatc ttgtattctg aaagctgaga   2640

aacggctggt cagctggaag gctggtggat gggcaggagt gagccaagct gaggcgttct   2700

gcaagaagca ggtctgagtc tgtccaacca atttgtatcc tgtggggaga acaacttcat   2760

tcttaacata ccctacaaac cagaaaacaa gtttttaagg aagatgctgg gcatgctgat   2820

agcttttctg gtctcctaag gaagagtttt taaaactaaa tccaaggaag aaaaatgtaa   2880

caacacgtgg aagtgaacac tggatgaata agcttgtttc ccaaattaga atcctaacgt   2940

ccatatttag cttcatgtat tcccctttgg cttccacagt tcaactcctt ttattttgag   3000

acagggtctc gctgtgtcgc cccagctgga gtatagtggc actacctcgg ctcactgcaa   3060

cctccactcc ccgggttcaa gcaattctca gagtagctgg gattacagat gcccgccacc   3120

acatctggct aatttttttt tttttttttt agtagacacg ggattttgct atgttgccca   3180

ggctggtctt gaactcctgg cctcaagtga tccacccgcc ttggccttcc aaagtgttga   3240

gattacaggc gtgagccacg gtgcccagcc catctcttag tcttccattc ccttggtgaa   3300

tttggaaact tgaaaaactt ggggacttga cagcaggctc catgttcttc tggcctcact   3360

gtactgtgta aggaaagagc tgcttgtcag gaacggaaga ggggacgcta gtaaaaaaaa   3420

aaaaattgga ttccccaact ggactaaata ggagtttttc aggtttgtag taacgtgaaa   3480

ctctcctaga tcgaagcagt tagactggcc tatgtggcct tctcagggtt tgtgattcag   3540

ttcttagcga ttcttggcct gataagttta tgaacacagc cccacattca agccgtggcc   3600

aatcccagct gttctcactg ctcttgggag gtgttgtccc agtcagtgtt tctgcagctt   3660

ccatttgttg ttgttatcca gtgtaagcac ctgttgaatg cagatgtgct gagttagagg   3720

tgggatttgg aaaagggctg ctatttctgc tgttgagatt tcagaggcta tactcttttt   3780

ttttcttttc tttttttttt ttttttgaga cggcatctca ctcttatcgc ccaggctgga   3840

gtgcaatggc gtgatctcgg ctcactgcaa cctccacctc ctgggttcaa gggattctcc   3900

tgcctcagcc tcctgagtag ctgggattac aggcacctac cacaattctc ggctaatttt   3960

ttttgtattt ttggtagaga cggggtttca ccaggttggc cagggtggtc tcgaacacct   4020

gacctcagat gatccaccca cctcggcctc ccagtgtggg tgggattaca ggcatgagcc   4080

accgcgcctg gcctcagagg ctatactctt ataattttgt tctgagggga gacagggaaa   4140

gggttagaca acttgaaaca ttgaccctgt ataaaaatgc aaaattctca atgtgtattt   4200

ataaatttct attttttata actttatggg acttcttaga ggccaaaagt agtaaacatg   4260

cagattaaaa atgtttatga aaatctcaat aaaaattcat aataaaaact ttgtaaataa   4320

ata                                                                 4323


<210>  1776
<211>  310
<212>  PRT
<213>  Homosapiens

<400>  1776

Met Ala Asp Ala Ala Ala Thr Ala Gly Ala Gly Gly Ser Gly Thr Arg 
1               5                   10                  15      


Ser Gly Ser Lys Gln Ser Thr Asn Pro Ala Asp Asn Tyr His Leu Ala 
            20                  25                  30          


Arg Arg Arg Thr Leu Gln Val Val Val Ser Ser Leu Leu Thr Glu Ala 
        35                  40                  45              


Gly Phe Glu Ser Ala Glu Lys Ala Ser Val Glu Thr Leu Thr Glu Met 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Ser Glu Ile Gly Arg Ser Ala Lys Ser Tyr Cys 
65                  70                  75                  80  


Glu His Thr Ala Arg Thr Gln Pro Thr Leu Ser Asp Ile Val Val Thr 
                85                  90                  95      


Leu Val Glu Met Gly Phe Asn Val Asp Thr Leu Pro Ala Tyr Ala Lys 
            100                 105                 110         


Arg Ser Gln Arg Met Val Ile Thr Ala Pro Pro Val Thr Asn Gln Pro 
        115                 120                 125             


Val Thr Pro Lys Ala Leu Thr Ala Gly Gln Asn Arg Pro His Pro Pro 
    130                 135                 140                 


His Ile Pro Ser His Phe Pro Glu Phe Pro Asp Pro His Thr Tyr Ile 
145                 150                 155                 160 


Lys Thr Pro Thr Tyr Arg Glu Pro Val Ser Asp Tyr Gln Val Leu Arg 
                165                 170                 175     


Glu Lys Ala Ala Ser Gln Arg Arg Asp Val Glu Arg Ala Leu Thr Arg 
            180                 185                 190         


Phe Met Ala Lys Thr Gly Glu Thr Gln Ser Leu Phe Lys Asp Asp Val 
        195                 200                 205             


Ser Thr Phe Pro Leu Ile Ala Ala Arg Pro Phe Thr Ile Pro Tyr Leu 
    210                 215                 220                 


Thr Ala Leu Leu Pro Ser Glu Leu Glu Met Gln Gln Met Glu Glu Thr 
225                 230                 235                 240 


Asp Ser Ser Glu Gln Asp Glu Gln Thr Asp Thr Glu Asn Leu Ala Leu 
                245                 250                 255     


His Ile Ser Met Glu Asp Ser Gly Ala Glu Lys Glu Asn Thr Ser Val 
            260                 265                 270         


Leu Gln Gln Asn Pro Ser Leu Ser Gly Ser Arg Asn Gly Glu Glu Asn 
        275                 280                 285             


Ile Ile Asp Asn Pro Tyr Leu Arg Pro Val Lys Lys Pro Lys Ile Arg 
    290                 295                 300                 


Arg Lys Lys Ser Leu Ser 
305                 310 


<210>  1777
<211>  4463
<212>  DNA
<213>  Homosapiens

<400>  1777
atgaccgtca ctgcagattt tcaagcaaat gcccaggaaa accatgggct ggctgtgccc     60

accccctcgg ttccagatga ttttgcagac aaagaagtga caggtaccag ctcactagtc    120

aatggcaacc tccgactgta cagctctgtg gcccccccac cgcctcctgt gccagcccca    180

gcacccccag ctccagcatc tcctcacaca gtggggactc gtctctttcc ccctgggggt    240

gtcaccaagt ggaaatcaga tgtagcactg aatggcaggc aggcagaggc caccagagcc    300

agccccccga gaagccctgc tgagccaaag gggagcgccc tgggacctaa cccagagccc    360

catctcacct tcccccgttc tttcaaagtg cctcccccaa ccccagtcag gacttcgtcc    420

atcccagttc aggaagcaca agaggctccc cgaaaggaag agggggccac caagaaggct    480

cccagccgac tcccactgcc tcccagcttc cacatccgcc ccgcctccca ggtctaccca    540

gacagggccc ccgagccaga ctgccctggg gagctcaagg ccacagcacc agccagccca    600

aggcttgcac ccccacttcc cccagctgca cctcctttgc cctgtgctca gaaggcagcc    660

catccacctg ctgggtttac aaaaacccct aaatccagct ctcctgctct caaacccaaa    720

cccaaccccc ccagcccaga gaacacagcg tcttcagcac ctgtggactg gagggacccc    780

agccagatgg aaaagctgcg gaacgagctg gcagcctatc tctgtggctc caggagagag    840

gaccgattcc tcagtcacag gccaggccca acagtggccc ctcagagcaa ggagggcaag    900

aagggccccc gcctgcctga gaaggagact ctcctgagcc tgccagcaaa ggacactccc    960

ccaggtgttc ctgaaaagag tcttggcggc agcagcctga cagagacaga ggctgccccc   1020

agcctgaccc tgccctctgt ggactacatt ccccaagact ctccaactcc cagtgtgcgg   1080

cagatccgga atgagctgga ggcccggctc tcctcagcag cagagaagga ggctaagccc   1140

agcataggat ctctgccccc taagcctcgg ctagaagggg gaagaatttg tgaaaacggg   1200

gctgatgatg acaaactctc caagcctgtg gccaagaatc tgccacctca atccaccacc   1260

ctgctgccaa ctacatcact ccagcccaag gctatgttgg gaccagccat accacccaag   1320

gccacacctg agccagccat accacccaag gctacacttt ggccagccac accacccaag   1380

gccacacttg ggccagccac accactcaag gccacatctg ggccaaccac accactcaag   1440

gccacatctg gccctgccat agcatctaca gccacaactc tgcccaccac cacatcccaa   1500

ctgatggcag agaaggactc aggcccagct ggccagccag agaagccagc atctcaagaa   1560

gtttccactc cctcccaggc aaggggagag gggtccccct cagaggccac taggctgccc   1620

acacagggag cccgctcatc tgcagccttc ccaccaaaga catctcctgg tggaggagag   1680

gtgccatgtc tctacaagcc ccactgccac cagagcagcc tcagccgtga ggttgctgtg   1740

gtgatgccca ccctggccag aggaggggct gcagggccag gggagcccgt ggaggtgaag   1800

gagcccccag ggctgccagc caagcctcct gcctcggccc agcccactga tgaactcctc   1860

aggcacccgg tgactgggga ggtggtggag cggggctcgc cgatggccct gctcctggcg   1920

gccaggcaga gggctcagaa gggaaggtct gtaggggctg ccctgggtcg gtcctctctg   1980

ccaggaagtc tccgtgacca cagccaccaa gccgaggcca gctctgacag catcttccac   2040

agccagggca cgcccaactc cttcactgtg gtgcccaagt tacccaagga ggctgagaag   2100

gactccccgc tgacgaccga aatacccaat aagtgggggc cgcggctggg aagagacgca   2160

gagggcacag agctgagccg caggcacaac tggacaaagc cagagcccca ggcccctgtg   2220

gcctgggaaa gagtagctcc ctccaacctc ccccagggcc acccgctgcc caagtccttc   2280

tcctccccac cttctccttc gaacaagagg gaggaggagg aggaggagtt caacttcgag   2340

gtcatcccac cgccgccaga gttcagcaat gaccctgagc ccccggcccc ggccctccag   2400

tatctgggcc gccagagctc ccctccccgg aacaactact cagacttgag gcagctcccg   2460

aacgctggcc ccggggcgcc cccggctctc ggcttctcgc gctttcccgc gggcgcgcgc   2520

tacgccgggg ctgggggcct ggagcgcttc tcgggagggg gccgctcgct cataaagaag   2580

cgcctgtacg tcggggagcc gcaccgaggc ccagggctac cccacggtgg caccggccgc   2640

agcctgagct ctcccaactg cttcgggccg cagcccggag gccccgagat gcggcgcgtg   2700

aactcggcgg gtcgcgcgcc ccccggaggc ctgcacgcgc cgaggctgtc cctggagggc   2760

gccgcccggg gcgccgcgga ggccaagcac aaagcgcccg gcagcgccga ctacggcttc   2820

gccccagctg ccggcaggtc tccctacacc accacccgct atggaagccc catcaacacg   2880

ttcaccgtga ggcctgggac ccgccatccc atctcctatg tctgctcagg ggcccatcgg   2940

aaagccacct cctgagccag gggttctctt agctctactc caacaaactg tgtctttaag   3000

gatctgggca cttgtttctt gtggggggtg ggaggtacac agcaggtgtt gggcgacctg   3060

actcagacac agaggagtct ttgatcccca aagaccaacg atgagaagca gtggcccagg   3120

aagaccgaga gtgggcttct gtttcccaaa gcgctggtgt gactgtggac tgtttacacg   3180

tggggggtgg gaggggaagg agggtagaga gaaggaacca ttaaggacct gggcgctgag   3240

tttctgctct ctggtactat ctgctttagc aagagttatt taaaacagtt ttacaagcac   3300

ggcctactga gcaggttctg aaagcaaggg gtggggcact gactgaactg gaacccatcg   3360

agatagctgt gattgcctgt caggcccttg caaagggctg aggcccagct ctgtctggtg   3420

ggtgtgcagg gcaccgaagg gagatcttta gcctccatca cctgccatcc caagcaagag   3480

tggacacctg gggttcctag ccgcattgag gtgggaccag gaatgtgtat gtataacatg   3540

tggagaagga ccatgtgtgg ggtggggagt gaagctccca catgtggaat ggaagccctt   3600

tgcattggcc aagggcagag gtgggagatt gatggttcat ttttccttgg ccctagccct   3660

tagctacagg gaggcctaga gagaggacac ttggcaagtt taggatggga aacaaggtta   3720

agcctggctt tgctattcag acctgtgcag ccctgatttt ggggactggg cccaaggagc   3780

catgagtctt aggcttgaca ctaggggcct tacatggcca ggtctcatat gggatttgga   3840

gaaggcattt ttcctaacac tgatactaca agtcaccaat actcttgatg ccttaagatg   3900

ctagaaagcc ttggagagtg gaggcagcag agatgggaat ggaggtctga agaagcttgc   3960

tgctgttggg gaatgtgttt gggaaagtca agagtggtag gattggttgg ctgggcgcgg   4020

tggctcacac ctgtaatccc agcactttgg gaggccgagg ccggtggatc acttgaggtc   4080

agaagttcga gaccagcctg cccaaatggt gaaaccccat ctctactaaa aatacggaaa   4140

aaaaaaaaaa aagagtgcta ggattgggcc agttaagagc aggggagacc tggctgggca   4200

tggtggctca cacctgtaat tctagcactt tgggaggctg aggcgggtgg atcatgaggt   4260

caagagatta agaccatcct ggcctacatg gcgaaaccct gtctctacta aaaataaaaa   4320

aatgacctgg gcatggtggt gggcgcctgt agtcccagct actcggggcg ctgaggcagg   4380

agaatcgctc gaacccagga ggtggaggtt gcagtgagcc gagattgcac aattgcactc   4440

cagcctggcg acagagcgag act                                           4463


<210>  1778
<211>  984
<212>  PRT
<213>  Homosapiens

<400>  1778

Met Thr Val Thr Ala Asp Phe Gln Ala Asn Ala Gln Glu Asn His Gly 
1               5                   10                  15      


Leu Ala Val Pro Thr Pro Ser Val Pro Asp Asp Phe Ala Asp Lys Glu 
            20                  25                  30          


Val Thr Gly Thr Ser Ser Leu Val Asn Gly Asn Leu Arg Leu Tyr Ser 
        35                  40                  45              


Ser Val Ala Pro Pro Pro Pro Pro Val Pro Ala Pro Ala Pro Pro Ala 
    50                  55                  60                  


Pro Ala Ser Pro His Thr Val Gly Thr Arg Leu Phe Pro Pro Gly Gly 
65                  70                  75                  80  


Val Thr Lys Trp Lys Ser Asp Val Ala Leu Asn Gly Arg Gln Ala Glu 
                85                  90                  95      


Ala Thr Arg Ala Ser Pro Pro Arg Ser Pro Ala Glu Pro Lys Gly Ser 
            100                 105                 110         


Ala Leu Gly Pro Asn Pro Glu Pro His Leu Thr Phe Pro Arg Ser Phe 
        115                 120                 125             


Lys Val Pro Pro Pro Thr Pro Val Arg Thr Ser Ser Ile Pro Val Gln 
    130                 135                 140                 


Glu Ala Gln Glu Ala Pro Arg Lys Glu Glu Gly Ala Thr Lys Lys Ala 
145                 150                 155                 160 


Pro Ser Arg Leu Pro Leu Pro Pro Ser Phe His Ile Arg Pro Ala Ser 
                165                 170                 175     


Gln Val Tyr Pro Asp Arg Ala Pro Glu Pro Asp Cys Pro Gly Glu Leu 
            180                 185                 190         


Lys Ala Thr Ala Pro Ala Ser Pro Arg Leu Ala Pro Pro Leu Pro Pro 
        195                 200                 205             


Ala Ala Pro Pro Leu Pro Cys Ala Gln Lys Ala Ala His Pro Pro Ala 
    210                 215                 220                 


Gly Phe Thr Lys Thr Pro Lys Ser Ser Ser Pro Ala Leu Lys Pro Lys 
225                 230                 235                 240 


Pro Asn Pro Pro Ser Pro Glu Asn Thr Ala Ser Ser Ala Pro Val Asp 
                245                 250                 255     


Trp Arg Asp Pro Ser Gln Met Glu Lys Leu Arg Asn Glu Leu Ala Ala 
            260                 265                 270         


Tyr Leu Cys Gly Ser Arg Arg Glu Asp Arg Phe Leu Ser His Arg Pro 
        275                 280                 285             


Gly Pro Thr Val Ala Pro Gln Ser Lys Glu Gly Lys Lys Gly Pro Arg 
    290                 295                 300                 


Leu Pro Glu Lys Glu Thr Leu Leu Ser Leu Pro Ala Lys Asp Thr Pro 
305                 310                 315                 320 


Pro Gly Val Pro Glu Lys Ser Leu Gly Gly Ser Ser Leu Thr Glu Thr 
                325                 330                 335     


Glu Ala Ala Pro Ser Leu Thr Leu Pro Ser Val Asp Tyr Ile Pro Gln 
            340                 345                 350         


Asp Ser Pro Thr Pro Ser Val Arg Gln Ile Arg Asn Glu Leu Glu Ala 
        355                 360                 365             


Arg Leu Ser Ser Ala Ala Glu Lys Glu Ala Lys Pro Ser Ile Gly Ser 
    370                 375                 380                 


Leu Pro Pro Lys Pro Arg Leu Glu Gly Gly Arg Ile Cys Glu Asn Gly 
385                 390                 395                 400 


Ala Asp Asp Asp Lys Leu Ser Lys Pro Val Ala Lys Asn Leu Pro Pro 
                405                 410                 415     


Gln Ser Thr Thr Leu Leu Pro Thr Thr Ser Leu Gln Pro Lys Ala Met 
            420                 425                 430         


Leu Gly Pro Ala Ile Pro Pro Lys Ala Thr Pro Glu Pro Ala Ile Pro 
        435                 440                 445             


Pro Lys Ala Thr Leu Trp Pro Ala Thr Pro Pro Lys Ala Thr Leu Gly 
    450                 455                 460                 


Pro Ala Thr Pro Leu Lys Ala Thr Ser Gly Pro Thr Thr Pro Leu Lys 
465                 470                 475                 480 


Ala Thr Ser Gly Pro Ala Ile Ala Ser Thr Ala Thr Thr Leu Pro Thr 
                485                 490                 495     


Thr Thr Ser Gln Leu Met Ala Glu Lys Asp Ser Gly Pro Ala Gly Gln 
            500                 505                 510         


Pro Glu Lys Pro Ala Ser Gln Glu Val Ser Thr Pro Ser Gln Ala Arg 
        515                 520                 525             


Gly Glu Gly Ser Pro Ser Glu Ala Thr Arg Leu Pro Thr Gln Gly Ala 
    530                 535                 540                 


Arg Ser Ser Ala Ala Phe Pro Pro Lys Thr Ser Pro Gly Gly Gly Glu 
545                 550                 555                 560 


Val Pro Cys Leu Tyr Lys Pro His Cys His Gln Ser Ser Leu Ser Arg 
                565                 570                 575     


Glu Val Ala Val Val Met Pro Thr Leu Ala Arg Gly Gly Ala Ala Gly 
            580                 585                 590         


Pro Gly Glu Pro Val Glu Val Lys Glu Pro Pro Gly Leu Pro Ala Lys 
        595                 600                 605             


Pro Pro Ala Ser Ala Gln Pro Thr Asp Glu Leu Leu Arg His Pro Val 
    610                 615                 620                 


Thr Gly Glu Val Val Glu Arg Gly Ser Pro Met Ala Leu Leu Leu Ala 
625                 630                 635                 640 


Ala Arg Gln Arg Ala Gln Lys Gly Arg Ser Val Gly Ala Ala Leu Gly 
                645                 650                 655     


Arg Ser Ser Leu Pro Gly Ser Leu Arg Asp His Ser His Gln Ala Glu 
            660                 665                 670         


Ala Ser Ser Asp Ser Ile Phe His Ser Gln Gly Thr Pro Asn Ser Phe 
        675                 680                 685             


Thr Val Val Pro Lys Leu Pro Lys Glu Ala Glu Lys Asp Ser Pro Leu 
    690                 695                 700                 


Thr Thr Glu Ile Pro Asn Lys Trp Gly Pro Arg Leu Gly Arg Asp Ala 
705                 710                 715                 720 


Glu Gly Thr Glu Leu Ser Arg Arg His Asn Trp Thr Lys Pro Glu Pro 
                725                 730                 735     


Gln Ala Pro Val Ala Trp Glu Arg Val Ala Pro Ser Asn Leu Pro Gln 
            740                 745                 750         


Gly His Pro Leu Pro Lys Ser Phe Ser Ser Pro Pro Ser Pro Ser Asn 
        755                 760                 765             


Lys Arg Glu Glu Glu Glu Glu Glu Phe Asn Phe Glu Val Ile Pro Pro 
    770                 775                 780                 


Pro Pro Glu Phe Ser Asn Asp Pro Glu Pro Pro Ala Pro Ala Leu Gln 
785                 790                 795                 800 


Tyr Leu Gly Arg Gln Ser Ser Pro Pro Arg Asn Asn Tyr Ser Asp Leu 
                805                 810                 815     


Arg Gln Leu Pro Asn Ala Gly Pro Gly Ala Pro Pro Ala Leu Gly Phe 
            820                 825                 830         


Ser Arg Phe Pro Ala Gly Ala Arg Tyr Ala Gly Ala Gly Gly Leu Glu 
        835                 840                 845             


Arg Phe Ser Gly Gly Gly Arg Ser Leu Ile Lys Lys Arg Leu Tyr Val 
    850                 855                 860                 


Gly Glu Pro His Arg Gly Pro Gly Leu Pro His Gly Gly Thr Gly Arg 
865                 870                 875                 880 


Ser Leu Ser Ser Pro Asn Cys Phe Gly Pro Gln Pro Gly Gly Pro Glu 
                885                 890                 895     


Met Arg Arg Val Asn Ser Ala Gly Arg Ala Pro Pro Gly Gly Leu His 
            900                 905                 910         


Ala Pro Arg Leu Ser Leu Glu Gly Ala Ala Arg Gly Ala Ala Glu Ala 
        915                 920                 925             


Lys His Lys Ala Pro Gly Ser Ala Asp Tyr Gly Phe Ala Pro Ala Ala 
    930                 935                 940                 


Gly Arg Ser Pro Tyr Thr Thr Thr Arg Tyr Gly Ser Pro Ile Asn Thr 
945                 950                 955                 960 


Phe Thr Val Arg Pro Gly Thr Arg His Pro Ile Ser Tyr Val Cys Ser 
                965                 970                 975     


Gly Ala His Arg Lys Ala Thr Ser 
            980                 


<210>  1779
<211>  1976
<212>  DNA
<213>  Homosapiens

<400>  1779
cagaagttcc acctcaccat caagaaaggc cctggtccag gatgtgcaag gtgtgatgaa     60

atcacagggc tggggaaggt cagctcgggg tcacaagaag cctgatgggc aggaaagagc    120

atgaaagccc cagccagcct cacctgtgcg gctgggagga ctcacagaaa ccctctgtac    180

ccagtcatgg gccaaagaca ccgtcatgca agggggtgaa ggctccacac tcgtcccggc    240

cccgggcgtg gaagcaggac ctcgagcagt ctctggcagc agcctatgtg ccggtcgttg    300

tggactctaa ggggcagaat ccggacaagc tcagggtaca gtctcccctg gggctgcaag    360

gatttagtgg agactcttaa caccagttct ctggcatctg tgagtttgag tgtgggccat    420

catcttcttc cttctgctct ctccctctcc acatttcccg gtaccatctg atccatcagg    480

cccttctttg ctcaggcctg aaggactcag gcctgtgaga gaggacggcc ccgttgtcgg    540

ccaagacacc tttgggcgag gagcagcgaa cagggcctgt ccatctcaga cgtcagcccc    600

ctgaaggcct gagcaatggg caacgtgatg gagggaaagt cagtggagga gctgagcagc    660

accgagtgcc accagtggta caagaagttc atgactgagt gcccctctgg ccaactcacc    720

ctctatgagt tccgccagtt cttcggcctc aagaacctga gcccgtcggc cagccagtac    780

gtggaacaga tgtttgagac ttttgacttc aacaaggacg gctacattga tttcatggag    840

tacgtggcag cgctcagctt ggtcctcaag gggaaggtgg aacagaagct ccgctggtac    900

ttcaagctct atgatgtaga tggcaacggc tgcattgacc gcgatgagct gctcaccatc    960

atccaggcca ttcgcgccat taacccctgc agcgatacca ccatgactgc agaggagttc   1020

accgatacag tgttctccaa gattgacgtc aacggggatg gggaactctc cctggaagag   1080

tttatagagg gcgtccagaa ggaccagatg ctcctggaca cactgacacg aagcctggac   1140

cttacccgca tcgtgcgcag gctccagaat ggcgagcaag acgaggaggg ggctgacgag   1200

gccgctgagg cagccggctg agtgcaccgc ccggctgctt ctgcactagc gggtggggtg   1260

gtatggtggt gcctgttggt ggtgttcttg tcttaaccct agatagaatc taatgaactc   1320

agaggcttag ctcgcctctt tagggtccat ggtggcagca gagaggcaga agtgggagtc   1380

cagagccagg aacagtgaag gatggttcct ggcccctctg agtgacagct ggtggcagca   1440

ctccttgctg gggggcactg ttcaacatcc ctctgccgtc gggtgacccc ctagcccttc   1500

tgactcctct cccagctttt cccagctttc cccactgagc ttctccagtc catgctcttc   1560

tggacgtgga ctctctgagg cagaactgag cttttccagg cctcttatgg aatcctgcag   1620

atccagtggc tgcagcttca atcccagtgc tgcaatcaca catccattct gccctggggg   1680

accctggagc ctacttgtgc gctttgcatt tcattgattg acgcctccct tcaacaagca   1740

tttactgagc gcctactatg tactaatgct agatgttaga tgtacaaaga agacagtttt   1800

catcctctag gaactcatag gctaatggtg agacacacag acaaacatca ttataataaa   1860

atatgctaag agaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa       1976


<210>  1780
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  1780

Met Gly Asn Val Met Glu Gly Lys Ser Val Glu Glu Leu Ser Ser Thr 
1               5                   10                  15      


Glu Cys His Gln Trp Tyr Lys Lys Phe Met Thr Glu Cys Pro Ser Gly 
            20                  25                  30          


Gln Leu Thr Leu Tyr Glu Phe Arg Gln Phe Phe Gly Leu Lys Asn Leu 
        35                  40                  45              


Ser Pro Ser Ala Ser Gln Tyr Val Glu Gln Met Phe Glu Thr Phe Asp 
    50                  55                  60                  


Phe Asn Lys Asp Gly Tyr Ile Asp Phe Met Glu Tyr Val Ala Ala Leu 
65                  70                  75                  80  


Ser Leu Val Leu Lys Gly Lys Val Glu Gln Lys Leu Arg Trp Tyr Phe 
                85                  90                  95      


Lys Leu Tyr Asp Val Asp Gly Asn Gly Cys Ile Asp Arg Asp Glu Leu 
            100                 105                 110         


Leu Thr Ile Ile Gln Ala Ile Arg Ala Ile Asn Pro Cys Ser Asp Thr 
        115                 120                 125             


Thr Met Thr Ala Glu Glu Phe Thr Asp Thr Val Phe Ser Lys Ile Asp 
    130                 135                 140                 


Val Asn Gly Asp Gly Glu Leu Ser Leu Glu Glu Phe Ile Glu Gly Val 
145                 150                 155                 160 


Gln Lys Asp Gln Met Leu Leu Asp Thr Leu Thr Arg Ser Leu Asp Leu 
                165                 170                 175     


Thr Arg Ile Val Arg Arg Leu Gln Asn Gly Glu Gln Asp Glu Glu Gly 
            180                 185                 190         


Ala Asp Glu Ala Ala Glu Ala Ala Gly 
        195                 200     


<210>  1781
<211>  2288
<212>  DNA
<213>  Homosapiens

<400>  1781
agtcacccag gagatgatgg agaggctgat caggcctcct ggaaagggag gaagagggcc     60

ctagttggag agatccatca gcagaagcca gggaggagat acagaccctt gctccctgac    120

gctcctcagg gctagcatgg ggcaggagtt tagctgggag gaggcggagg cagctggcga    180

gatagatgtg gcggagctcc aggagtggta caagaagttt gtgatggagt gccccagcgg    240

cacactcttt atgcatgagt ttaagcgctt cttcaaggtc acagacgatg aggaggcctc    300

ccagtacgta gagggcatgt tccgagcctt cgacaagaat ggggacaaca ccatcgactt    360

cctggagtac gtggcagctc tgaatctcgt gctgaggggc accctggagc acaagctgaa    420

gcggacattc aagatctatg ataaggatgg caatggctgc atcgaccgcc tggagctact    480

caacattgtg gagggaattt accagctgaa gaaagcctgc cggcgagagc tacaaactga    540

gcaaggccag ctgctcacac ccgaggaggt cgtggacagg atcttcctcc tggtggatga    600

gaatggagat ggccagctgt ctctgaacgg gtttgttgaa ggtgcccgtc gggacaagtg    660

ggtgatgaag atgctgcaga tggacatgaa tcccagcagc tggctcgctc agcagagacg    720

gaaaagtgcc atgttctgag gagtctgggg cccctccacg actccaggct cacccaggtt    780

tccagggtag taggagggtc cctggctcag cctgctcatg cccactcttc ccctggtgtt    840

gacttcctgg caccccctgt gcagggctga gtggggatgg ggaagggctg ctgggtttga    900

agtggccaac agggcatagt ccattttgga ggagtccctg ggatggtgaa gggaattcag    960

ttacttttcc tgttcagccg ctcctgggag gactgtgcct tggctgggtg gttgtggggc   1020

tcccacagtt tctgggtgtt ctcagttgga agcaagagcc aactgagggg tgagggtccc   1080

acagaccaaa tcagaaatga gaacacaaag actggtagga ggcaggggtg ggagggtgtt   1140

gagactgaag aaaaggcagg agttgccggg cacggtggct cacgcctgta atcccagcac   1200

tttgggaggc cgaggcgggc agatcacgag gtcaggagat cgagaccatc ctggctaaca   1260

cggggtgaaa ccccgtctct actaaaaata caaaaaatca gccgggtgag gtggcgggcg   1320

cctgtagtcc cagctactca ggaggctgag gcaagagaat ggcgtgaacc ccagggggcc   1380

gagcctacag tgagccgaga ttgcgccact gcactccagc ctggacgaca gtgagactcc   1440

gtctcaaaaa aaaaaaaaag aaagaaaaga aaaggcagga gttttggggg gcagggggca   1500

gcaataattc tataacttcc gggatgctga ggggcgttca tggggaggac cctggcctcc   1560

tcctccccaa ggcatcctca ccagtggtgt caacaggaaa aatggcagca aatacgctgc   1620

aggctgtggt ctttctgcct ttgaaagggt cagctgtact taaagggact gtttcagctc   1680

tgcctgggtg ctgctctggg accccctgct gccaacccac cactccccca acaatcctct   1740

ctttccatcc atatccccca gtatggacct tccacaactc ccagccataa gctgaatgtt   1800

tctctttaaa ggatggagaa aacttctgtc tgtctctggc aagaattggg ggactgttga   1860

ctgggattgt gggctgggct tggcttctaa ctgctgtgtg acccaagaca gccacttctc   1920

ctccctaacc ttggttatgt cttggcagca cagtgagcag gtcggactag gcgaacagtt   1980

ttggattatt gtgtttttag atgtggaatt attttttgtt atataaactc ttatgtgtaa   2040

ccccaatata gaaactagat taaaagggag tctctctggt tgaaagggga gctgagtacc   2100

ctctggaact ggaggcacct ctgaaaaaag caaactgaaa accagtgccc tgggtcactg   2160

ttactcctat aagacagttt aaagtgagac ctggaaaaac atttgcttta ccttgaatag   2220

ataggttttt atgttggtat ataagaaata aaactaacct attaaacctg aaaaaaaaaa   2280

aaaaaaaa                                                            2288


<210>  1782
<211>  200
<212>  PRT
<213>  Homosapiens

<400>  1782

Met Gly Gln Glu Phe Ser Trp Glu Glu Ala Glu Ala Ala Gly Glu Ile 
1               5                   10                  15      


Asp Val Ala Glu Leu Gln Glu Trp Tyr Lys Lys Phe Val Met Glu Cys 
            20                  25                  30          


Pro Ser Gly Thr Leu Phe Met His Glu Phe Lys Arg Phe Phe Lys Val 
        35                  40                  45              


Thr Asp Asp Glu Glu Ala Ser Gln Tyr Val Glu Gly Met Phe Arg Ala 
    50                  55                  60                  


Phe Asp Lys Asn Gly Asp Asn Thr Ile Asp Phe Leu Glu Tyr Val Ala 
65                  70                  75                  80  


Ala Leu Asn Leu Val Leu Arg Gly Thr Leu Glu His Lys Leu Lys Arg 
                85                  90                  95      


Thr Phe Lys Ile Tyr Asp Lys Asp Gly Asn Gly Cys Ile Asp Arg Leu 
            100                 105                 110         


Glu Leu Leu Asn Ile Val Glu Gly Ile Tyr Gln Leu Lys Lys Ala Cys 
        115                 120                 125             


Arg Arg Glu Leu Gln Thr Glu Gln Gly Gln Leu Leu Thr Pro Glu Glu 
    130                 135                 140                 


Val Val Asp Arg Ile Phe Leu Leu Val Asp Glu Asn Gly Asp Gly Gln 
145                 150                 155                 160 


Leu Ser Leu Asn Gly Phe Val Glu Gly Ala Arg Arg Asp Lys Trp Val 
                165                 170                 175     


Met Lys Met Leu Gln Met Asp Met Asn Pro Ser Ser Trp Leu Ala Gln 
            180                 185                 190         


Gln Arg Arg Lys Ser Ala Met Phe 
        195                 200 


<210>  1783
<211>  2112
<212>  DNA
<213>  Homosapiens

<400>  1783
ggtcgggacc ggcaagatgg cggcgcggac agcgttcggt gctgtgtgcc ggcgcctctg     60

gcagggattg gggaattttt ctgtaaacac ttctaagggc aatacagcca aaaatggtgg    120

cttgcttctc agtaccaata tgaagtgggt acagttttca aacctacacg ttgatgttcc    180

aaaggatttg accaaacctg tggtaacaat ctctgatgaa ccagacatat tatataagcg    240

cctctcggtt ttggtgaaag gtcacgataa ggctgtattg gacagttatg aatattttgc    300

tgtgcttgct gctaaagaac ttggtatctc tattaaagta catgaacctc caaggaaaat    360

agagcgattt actcttctcc aatcagtgca tatttacaag aagcacagag ttcagtatga    420

aatgagaaca ctttacagat gtttagagtt agaacatcta actggaagca cagcagatgt    480

ctacttggaa tatattcagc gaaacttacc tgaaggggtt gccatggaag taacaaagac    540

acaattagaa cagttaccag aacacatcaa ggagccaatc tgggaaacac tatcagaaga    600

aaaagaagaa agcaagtcat aaagcctcag ggaggccatt tttgcctaaa tttgaaatga    660

gggtgggcca gatgagtatg tttaagtgga gagtgcttcc agctgagatg atttgagtct    720

gtcctaactg ctccattgag ttctcgtgcc ctcatcagct gagggcaggg aatggaactt    780

taatggaaga accactttta tctattcttt ttattcattg tttcagttct gatttcagca    840

aacatgagca aaccactttg actgaaagca gaaagagtga aaattctatt ttgttacgct    900

actggtgttc aattattagt ttgtaccatt tttaatttat gtcagttgat gcatctgaaa    960

ataagtgctt ggagtgttcg tacccttatt tttttttaag attcctagaa ggaatctttg   1020

gttaattcag attgagcagt taaagttttt gctatttacc tttgtgcagg ctggcatatg   1080

ctaatttggg ggtggtaacc aaccgatttt atctcatgta agcattacat tttgaagact   1140

gaatatactt cacagcagat caaacacatt tatggcatgc actgacctct tcttggagcc   1200

cagaacttta tagagttgcc taccagggtt actgtaatgg aatttatgat cttaagaaat   1260

tactagttgt attatttatc ctatgattca ttcattcaat aagcttttac tgcataaact   1320

ttacatccag cactgtagtt aagtacccaa aattgaatag aaataatggc ttttgaaaat   1380

tgcacaaagc aggccaggca cggtggctca cgcctgtaat cccagcactt tgggaggccg   1440

aggcaggcgg atcacgaggt caagagatcc agaccatcct ggctaacacg gtgaaacccc   1500

gtctctaata aaaatacaaa aattagctgg acatggtggc acgtgcctgt aatcccagct   1560

actcaggagg ctgaggcagg agaatcgcgt gaacccgggc ccggtggagg ctgcagtgag   1620

acgagatcgc gccactgcac tccagcctgg cgacagagcg agacaccgtc tcaaaaaaaa   1680

aaaaaaagaa aattgtgcaa agcataggta aatatttttc tttattaagc ttctcactga   1740

gaagccctct ttattttggt aaatgtcact ctgtttgtta ggagatgtct gcttttccat   1800

gaaatgaaat agtggctaaa gccctgaaag aggcaagact acaatgggct gaaacagttg   1860

gtatagcaac cccagagaag tgcttcattt tctttttata gtagaagcag gtccatgtct   1920

tttgtggttt cctgcacatc tttggagtag ttatgacttc tcagtttttc cccccttaaa   1980

ctgcattgcc tattcttttt tcctgacatg ctatcaggta tcagtgtgtt gaatacataa   2040

tgcttgtgta tcagacttac gttactgtca tcaccattaa aagaattgca gccttgtgcc   2100

ccatgacctt ca                                                       2112


<210>  1784
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  1784

Met Ala Ala Arg Thr Ala Phe Gly Ala Val Cys Arg Arg Leu Trp Gln 
1               5                   10                  15      


Gly Leu Gly Asn Phe Ser Val Asn Thr Ser Lys Gly Asn Thr Ala Lys 
            20                  25                  30          


Asn Gly Gly Leu Leu Leu Ser Thr Asn Met Lys Trp Val Gln Phe Ser 
        35                  40                  45              


Asn Leu His Val Asp Val Pro Lys Asp Leu Thr Lys Pro Val Val Thr 
    50                  55                  60                  


Ile Ser Asp Glu Pro Asp Ile Leu Tyr Lys Arg Leu Ser Val Leu Val 
65                  70                  75                  80  


Lys Gly His Asp Lys Ala Val Leu Asp Ser Tyr Glu Tyr Phe Ala Val 
                85                  90                  95      


Leu Ala Ala Lys Glu Leu Gly Ile Ser Ile Lys Val His Glu Pro Pro 
            100                 105                 110         


Arg Lys Ile Glu Arg Phe Thr Leu Leu Gln Ser Val His Ile Tyr Lys 
        115                 120                 125             


Lys His Arg Val Gln Tyr Glu Met Arg Thr Leu Tyr Arg Cys Leu Glu 
    130                 135                 140                 


Leu Glu His Leu Thr Gly Ser Thr Ala Asp Val Tyr Leu Glu Tyr Ile 
145                 150                 155                 160 


Gln Arg Asn Leu Pro Glu Gly Val Ala Met Glu Val Thr Lys Thr Gln 
                165                 170                 175     


Leu Glu Gln Leu Pro Glu His Ile Lys Glu Pro Ile Trp Glu Thr Leu 
            180                 185                 190         


Ser Glu Glu Lys Glu Glu Ser Lys Ser 
        195                 200     


<210>  1785
<211>  3962
<212>  DNA
<213>  Homosapiens

<400>  1785
ctctgctcgc cccccatctc accccccaag cggatactgg tcttctcgtc ggattgccca     60

tgcacttgtt gcagaaacag ccaaggccct ggctgtggag aatgctgaag gaagaagacg    120

cagaagcagg acgaccctga aagattcagc ctcttcatcc tcaaacaggt cgcttctcgg    180

gagttcttgg tgttggaata ttttacagca aagcagtcga ccaggcctcc tcttcccacc    240

tgtccagcag catgaaagca gcatgattgg ccgaccgcag gagaagcccc cagaaccagg    300

cccccaactc agccatctgc ggaggtcaag gtgtgagcga cgtctcctca ccacagtgct    360

gtgtggtcta tacctcagcc agggagagga tgtgaaaccc cccgccctgc acatgagtgg    420

tacaggccaa caggaacacc tggctccagc cacgttcaca gacatgtcag ccgtggagta    480

gtgctgacac ttttctctca gcttctcagg gtttcagtcc ttttgggttt ggtttattta    540

ccttttttat ggttttgtgg ctggacgttc acaaccaagg cagacagcat gggtgaccag    600

caactgtaca agaccaacca tgtggcccat ggtagtgaga accttttcta ccaacagcca    660

ccacttggcg tccacagcgg gctgagccca ctgatggcta ccaatacacc tactcccagg    720

ccagcgagat ccggacccag aagcttacca gcggtgtctt acacaagctg gactctttca    780

cccaggtgtt tgccaaccaa aacctgcgaa ttcaggtcaa caatatggcc caggtgctgc    840

acactcagtc agcagtgatg gatggagccc ctgacagtgc tctccgccag ctgctgtctc    900

agaagcccat ggagccccca gcaccggcta tcccttcccg ctaccagcag gtgccccagc    960

agcctcaccc tggtttcact ggtgggctgt ccaaaccagc tcttcaggtc gggcagcacc   1020

ctacccaagg gcacctgtat tatgactacc agcagcctct ggctcaggtg ccagtgcagg   1080

gaggacagcc actgcaggcc ccacagatgc tgtcacagca catgcaacag atgcagcagc   1140

accagtatta cccaccgcag caacagcagc aagccgggca acagcgtatc tccatgcaag   1200

aaatacagac gcagccgcaa caaattcgcc catcacagcc acagccgccg ccacagcagc   1260

agcagccgca gcagctacag ctgcagcagc ggcagggttc aatgcagata cctcagtatt   1320

atcagcccca acccatgatg cagcacttgc aagagcagca gcagcaacag atgcacctgc   1380

agcctccttc ttatcacagg gaccctcacc agtatacccc agagcaggca cacactgtcc   1440

agctgattcc cctgggctcc atgtcccagt actactacca ggagccccag cagccctaca   1500

gccaccccct ttaccagcag agccacctgt cccagcacca gcagcgtgag gacagtcagc   1560

tgaagaccta ctctagtgac agacaggccc aggccatgct gagctcccat ggggacctgg   1620

ggcctcctga cacaggaatg ggagacccag cgagctcaga tctgacccgg gtcagcagca   1680

ccctccccca tcgccccctc ctatccccca gtgggatcca cctcaacaac atggggcctc   1740

agcatcagca gctgtctccc agtgccatgt ggccccagat gcacctacct gatgggagag   1800

cccagccagg gtcccctgag tcaagtggcc aacccaaagg agcgtttggg gagcagtttg   1860

atgccaagaa caagctgaca tgctccatct gcctgaagga gttcaagaac ctgcctgccc   1920

tgaatggcca catgcggtcc cacgggggaa tgagggcctc ccccaacctc aaacaggaaa   1980

tccccaggaa gcatcagccg agtgtgccca aagccgagga gcccctcaag accgtgcagg   2040

agaagaaaaa gttccggcac cggtcggaac ctctcttcat cccgccgccg ccctcctaca   2100

acccgaaccc cgctgcctcc tactcgggcg ccaccctgta ccagagccag ctgcgctccc   2160

cgcgcgtcct cggggaccac ctgctcctgg accccaccca cgagctgccc ccttacacgc   2220

ccccacccat gctgagcccg gtgcgccagg gctcggggct cttcagcaat gtcctcatct   2280

ccggccacgg ccctggcgcc cacccgcagc tgcccctgac gcccctgacg cccacaccac   2340

gggtgctgct gtgtcgctcc aacagcatcg atggcagcaa cgtgacggtc accccagggc   2400

ctggagagca gactgtagat gttgaaccac gcatcaacat tggcttgaga ttccaagcag   2460

aaatccctga actccaagat atctctgccc tggcccagga cacacacaag gccacactgg   2520

tatggaagcc ctggccagaa ctagaaaacc atgacctcca gcaaagagtg gagaatcttc   2580

tgaatttgtg ctgttccagt gcattgccag gtggagggac caattctgaa tttgctttgc   2640

actctctgtt tgaggccaaa ggtgatgtga tggttgctct ggaaatgctg ctactgcgga   2700

agcctgtcag gttaaaatgt catcctttag caaattacca ctatgccggt tcggacaagt   2760

ggacctccct agaaagaaaa ctgtttaaca aagcactagc cacttacagc aaagacttta   2820

tttttgtaca gaagatggtg aagtccaaga cggtggctca gtgcgtggag tactactaca   2880

cgtggaaaaa gatcatgcgg ctggggcgga aacaccggac acgcctggca gaaatcatcg   2940

acgattgtgt gacaagtgaa gaagaagaag agttagagga ggaggaggag gaggacccgg   3000

aagaagatag gaaatccaca aaagaagaag agagtgaggt gccgaagtcc ccggagccac   3060

cacccgtccc cgtcctggct cccacggagg ggccgcccct gcaggccctg ggccagccct   3120

caggctcctt catctgtgaa atgcccaact gtggggctga ctgtagatgt catgtcactc   3180

cctttcttcc ccaggtgttc agctcccgac aggcactgaa tggccatgcc cgcatccacg   3240

ggggcaccaa ccaggtgacc aaggcccgag gtgccatccc ctctgggaag cagaagcctg   3300

gtggcaccca gagtgggtac tgttcggtaa agagctcacc ctctcacagc accaccagcg   3360

gcgagacaga ccccaccacc atcttcccct gcaaggagtg tggcaaagtc ttcttcaaga   3420

tcaaaagccg aaatgcacac atgaaaactc acaggcagca ggaggaacaa cagaggcaaa   3480

aggctcagaa ggcggctttt gcagctgaga tggcagccac gattgagagg actacggggc   3540

ccgtgggggc gccggggctg ctgcccctgg accagctgag tctgatcaaa cccatcaagg   3600

atgtggacat cctcgacgac gacgtcgtcc agcagttggg aggtgtcatg gaagaggctg   3660

aagttgtgga caccgatctt ctcttggatg atcaagattc agtcttgctt cagggtgacg   3720

cagaactata aagccctgtg tgtcacttag agacagtgaa aacccacggc ctccatcttc   3780

attaatcagg aaacctggac tgcctgcttg ttttgtaacc cttttaaact acctgtttta   3840

aaagtggtca ttttattcag gtttagaaaa aaaaatccta tttcttttcc ttttatttaa   3900

aaaaatttgt ttttgtgggg ggttgggggg aataaataat tggcacaact aaaaaaaaaa   3960

aa                                                                  3962


<210>  1786
<211>  968
<212>  PRT
<213>  Homosapiens

<400>  1786

Met Ala Gln Val Leu His Thr Gln Ser Ala Val Met Asp Gly Ala Pro 
1               5                   10                  15      


Asp Ser Ala Leu Arg Gln Leu Leu Ser Gln Lys Pro Met Glu Pro Pro 
            20                  25                  30          


Ala Pro Ala Ile Pro Ser Arg Tyr Gln Gln Val Pro Gln Gln Pro His 
        35                  40                  45              


Pro Gly Phe Thr Gly Gly Leu Ser Lys Pro Ala Leu Gln Val Gly Gln 
    50                  55                  60                  


His Pro Thr Gln Gly His Leu Tyr Tyr Asp Tyr Gln Gln Pro Leu Ala 
65                  70                  75                  80  


Gln Val Pro Val Gln Gly Gly Gln Pro Leu Gln Ala Pro Gln Met Leu 
                85                  90                  95      


Ser Gln His Met Gln Gln Met Gln Gln His Gln Tyr Tyr Pro Pro Gln 
            100                 105                 110         


Gln Gln Gln Gln Ala Gly Gln Gln Arg Ile Ser Met Gln Glu Ile Gln 
        115                 120                 125             


Thr Gln Pro Gln Gln Ile Arg Pro Ser Gln Pro Gln Pro Pro Pro Gln 
    130                 135                 140                 


Gln Gln Gln Pro Gln Gln Leu Gln Leu Gln Gln Arg Gln Gly Ser Met 
145                 150                 155                 160 


Gln Ile Pro Gln Tyr Tyr Gln Pro Gln Pro Met Met Gln His Leu Gln 
                165                 170                 175     


Glu Gln Gln Gln Gln Gln Met His Leu Gln Pro Pro Ser Tyr His Arg 
            180                 185                 190         


Asp Pro His Gln Tyr Thr Pro Glu Gln Ala His Thr Val Gln Leu Ile 
        195                 200                 205             


Pro Leu Gly Ser Met Ser Gln Tyr Tyr Tyr Gln Glu Pro Gln Gln Pro 
    210                 215                 220                 


Tyr Ser His Pro Leu Tyr Gln Gln Ser His Leu Ser Gln His Gln Gln 
225                 230                 235                 240 


Arg Glu Asp Ser Gln Leu Lys Thr Tyr Ser Ser Asp Arg Gln Ala Gln 
                245                 250                 255     


Ala Met Leu Ser Ser His Gly Asp Leu Gly Pro Pro Asp Thr Gly Met 
            260                 265                 270         


Gly Asp Pro Ala Ser Ser Asp Leu Thr Arg Val Ser Ser Thr Leu Pro 
        275                 280                 285             


His Arg Pro Leu Leu Ser Pro Ser Gly Ile His Leu Asn Asn Met Gly 
    290                 295                 300                 


Pro Gln His Gln Gln Leu Ser Pro Ser Ala Met Trp Pro Gln Met His 
305                 310                 315                 320 


Leu Pro Asp Gly Arg Ala Gln Pro Gly Ser Pro Glu Ser Ser Gly Gln 
                325                 330                 335     


Pro Lys Gly Ala Phe Gly Glu Gln Phe Asp Ala Lys Asn Lys Leu Thr 
            340                 345                 350         


Cys Ser Ile Cys Leu Lys Glu Phe Lys Asn Leu Pro Ala Leu Asn Gly 
        355                 360                 365             


His Met Arg Ser His Gly Gly Met Arg Ala Ser Pro Asn Leu Lys Gln 
    370                 375                 380                 


Glu Ile Pro Arg Lys His Gln Pro Ser Val Pro Lys Ala Glu Glu Pro 
385                 390                 395                 400 


Leu Lys Thr Val Gln Glu Lys Lys Lys Phe Arg His Arg Ser Glu Pro 
                405                 410                 415     


Leu Phe Ile Pro Pro Pro Pro Ser Tyr Asn Pro Asn Pro Ala Ala Ser 
            420                 425                 430         


Tyr Ser Gly Ala Thr Leu Tyr Gln Ser Gln Leu Arg Ser Pro Arg Val 
        435                 440                 445             


Leu Gly Asp His Leu Leu Leu Asp Pro Thr His Glu Leu Pro Pro Tyr 
    450                 455                 460                 


Thr Pro Pro Pro Met Leu Ser Pro Val Arg Gln Gly Ser Gly Leu Phe 
465                 470                 475                 480 


Ser Asn Val Leu Ile Ser Gly His Gly Pro Gly Ala His Pro Gln Leu 
                485                 490                 495     


Pro Leu Thr Pro Leu Thr Pro Thr Pro Arg Val Leu Leu Cys Arg Ser 
            500                 505                 510         


Asn Ser Ile Asp Gly Ser Asn Val Thr Val Thr Pro Gly Pro Gly Glu 
        515                 520                 525             


Gln Thr Val Asp Val Glu Pro Arg Ile Asn Ile Gly Leu Arg Phe Gln 
    530                 535                 540                 


Ala Glu Ile Pro Glu Leu Gln Asp Ile Ser Ala Leu Ala Gln Asp Thr 
545                 550                 555                 560 


His Lys Ala Thr Leu Val Trp Lys Pro Trp Pro Glu Leu Glu Asn His 
                565                 570                 575     


Asp Leu Gln Gln Arg Val Glu Asn Leu Leu Asn Leu Cys Cys Ser Ser 
            580                 585                 590         


Ala Leu Pro Gly Gly Gly Thr Asn Ser Glu Phe Ala Leu His Ser Leu 
        595                 600                 605             


Phe Glu Ala Lys Gly Asp Val Met Val Ala Leu Glu Met Leu Leu Leu 
    610                 615                 620                 


Arg Lys Pro Val Arg Leu Lys Cys His Pro Leu Ala Asn Tyr His Tyr 
625                 630                 635                 640 


Ala Gly Ser Asp Lys Trp Thr Ser Leu Glu Arg Lys Leu Phe Asn Lys 
                645                 650                 655     


Ala Leu Ala Thr Tyr Ser Lys Asp Phe Ile Phe Val Gln Lys Met Val 
            660                 665                 670         


Lys Ser Lys Thr Val Ala Gln Cys Val Glu Tyr Tyr Tyr Thr Trp Lys 
        675                 680                 685             


Lys Ile Met Arg Leu Gly Arg Lys His Arg Thr Arg Leu Ala Glu Ile 
    690                 695                 700                 


Ile Asp Asp Cys Val Thr Ser Glu Glu Glu Glu Glu Leu Glu Glu Glu 
705                 710                 715                 720 


Glu Glu Glu Asp Pro Glu Glu Asp Arg Lys Ser Thr Lys Glu Glu Glu 
                725                 730                 735     


Ser Glu Val Pro Lys Ser Pro Glu Pro Pro Pro Val Pro Val Leu Ala 
            740                 745                 750         


Pro Thr Glu Gly Pro Pro Leu Gln Ala Leu Gly Gln Pro Ser Gly Ser 
        755                 760                 765             


Phe Ile Cys Glu Met Pro Asn Cys Gly Ala Asp Cys Arg Cys His Val 
    770                 775                 780                 


Thr Pro Phe Leu Pro Gln Val Phe Ser Ser Arg Gln Ala Leu Asn Gly 
785                 790                 795                 800 


His Ala Arg Ile His Gly Gly Thr Asn Gln Val Thr Lys Ala Arg Gly 
                805                 810                 815     


Ala Ile Pro Ser Gly Lys Gln Lys Pro Gly Gly Thr Gln Ser Gly Tyr 
            820                 825                 830         


Cys Ser Val Lys Ser Ser Pro Ser His Ser Thr Thr Ser Gly Glu Thr 
        835                 840                 845             


Asp Pro Thr Thr Ile Phe Pro Cys Lys Glu Cys Gly Lys Val Phe Phe 
    850                 855                 860                 


Lys Ile Lys Ser Arg Asn Ala His Met Lys Thr His Arg Gln Gln Glu 
865                 870                 875                 880 


Glu Gln Gln Arg Gln Lys Ala Gln Lys Ala Ala Phe Ala Ala Glu Met 
                885                 890                 895     


Ala Ala Thr Ile Glu Arg Thr Thr Gly Pro Val Gly Ala Pro Gly Leu 
            900                 905                 910         


Leu Pro Leu Asp Gln Leu Ser Leu Ile Lys Pro Ile Lys Asp Val Asp 
        915                 920                 925             


Ile Leu Asp Asp Asp Val Val Gln Gln Leu Gly Gly Val Met Glu Glu 
    930                 935                 940                 


Ala Glu Val Val Asp Thr Asp Leu Leu Leu Asp Asp Gln Asp Ser Val 
945                 950                 955                 960 


Leu Leu Gln Gly Asp Ala Glu Leu 
                965             


<210>  1787
<211>  3925
<212>  DNA
<213>  Homosapiens

<400>  1787
ctctgctcgc cccccatctc accccccaag cggatactgg tcttctcgtc ggattgccca     60

tgcacttgtt gcagaaacag ccaaggccct ggctgtggag aatgctgaag gaagaagacg    120

cagaagcagg acgaccctga aagattcagc ctcttcatcc tcaaacaggt cgcttctcgg    180

gagttcttgg tgttggaata ttttacagca aagcagtcga ccaggcctcc tcttcccacc    240

tgtccagcag catgaaagca gcatgattgg ccgaccgcag gagaagcccc cagaaccagg    300

cccccaactc agccatctgc ggaggtcaag gtgtgagcga cgtctcctca ccacagtgct    360

gtgtggtcta tacctcagcc agggagagga tgtgaaaccc cccgccctgc acatgagtgg    420

tacaggccaa caggaacacc tggctccagc cacgttcaca gacatgtcag ccgtggagta    480

gtgctgacac ttttctctca gcttctcagg gtttcagtcc ttttgggttt ggtttattta    540

ccttttttat ggttttgtgg ctggacgttc acaaccaagg cagacagcat gggtgaccag    600

caactgtaca agaccaacca tgtggcccat ggtagtgaga accttttcta ccaacagcca    660

ccacttggcg tccacagcgg gctgagccca ctgatggcta ccaatacacc tactcccagg    720

ccagcgagat ccggacccag aagcttacca gcggtgtctt acacaagctg gactctttca    780

cccaggtgtt tgccaaccaa aacctgcgaa ttcaggtcaa caatatggcc caggtgctgc    840

acactcagtc agcagtgatg gatggagccc ctgacagtgc tctccgccag ctgctgtctc    900

agaagcccat ggagccccca gcaccggcta tcccttcccg ctaccagcag gtgccccagc    960

agcctcaccc tggtttcact ggtgggctgt ccaaaccagc tcttcaggtc gggcagcacc   1020

ctacccaagg gcacctgtat tatgactacc agcagcctct ggctcaggtg ccagtgcagg   1080

gaggacagcc actgcaggcc ccacagatgc tgtcacagca catgcaacag atgcagcagc   1140

accagtatta cccaccgcag caacagcagc aagccgggca acagcgtatc tccatgcaag   1200

aaatacagac gcagccgcaa caaattcgcc catcacagcc acagccgccg ccacagcagc   1260

agcagccgca gcagctacag ctgcagcagc ggcagggttc aatgcagata cctcagtatt   1320

atcagcccca acccatgatg cagcacttgc aagagcagca gcagcaacag atgcacctgc   1380

agcctccttc ttatcacagg gaccctcacc agtatacccc agagcaggca cacactgtcc   1440

agctgattcc cctgggctcc atgtcccagt actactacca ggagccccag cagccctaca   1500

gccaccccct ttaccagcag agccacctgt cccagcacca gcagcgtgag gacagtcagc   1560

tgaagaccta ctctagtgac agacaggccc aggccatgct gagctcccat ggggacctgg   1620

ggcctcctga cacaggaatg ggagacccag cgagctcaga tctgacccgg gtcagcagca   1680

ccctccccca tcgccccctc ctatccccca gtgggatcca cctcaacaac atggggcctc   1740

agcatcagca gctgtctccc agtgccatgt ggccccagat gcacctacct gatgggagag   1800

cccagccagg gtcccctgag tcaagtggcc aacccaaagg agcgtttggg gagcagtttg   1860

atgccaagaa caagctgaca tgctccatct gcctgaagga gttcaagaac ctgcctgccc   1920

tgaatggcca catgcggtcc cacgggggaa tgagggcctc ccccaacctc aaacaggaaa   1980

tccccaggaa gcatcagccg agtgtgccca aagccgagga gcccctcaag accgtgcagg   2040

agaagaaaaa gttccggcac cggtcggaac ctctcttcat cccgccgccg ccctcctaca   2100

acccgaaccc cgctgcctcc tactcgggcg ccaccctgta ccagagccag ctgcgctccc   2160

cgcgcgtcct cggggaccac ctgctcctgg accccaccca cgagctgccc ccttacacgc   2220

ccccacccat gctgagcccg gtgcgccagg gctcggggct cttcagcaat gtcctcatct   2280

ccggccacgg ccctggcgcc cacccgcagc tgcccctgac gcccctgacg cccacaccac   2340

gggtgctgct gtgtcgctcc aacagcatcg atggcagcaa cgtgacggtc accccagggc   2400

ctggagagca gactgtagat gttgaaccac gcatcaacat tggcttgaga ttccaagcag   2460

aaatccctga actccaagat atctctgccc tggcccagga cacacacaag gccacactgg   2520

tatggaagcc ctggccagaa ctagaaaacc atgacctcca gcaaagagtg gagaatcttc   2580

tgaatttgtg ctgttccagt gcattgccag gtggagggac caattctgaa tttgctttgc   2640

actctctgtt tgaggccaaa ggtgatgtga tggttgctct ggaaatgctg ctactgcgga   2700

agcctgtcag gttaaaatgt catcctttag caaattacca ctatgccggt tcggacaagt   2760

ggacctccct agaaagaaaa ctgtttaaca aagcactagc cacttacagc aaagacttta   2820

tttttgtaca gaagatggtg aagtccaaga cggtggctca gtgcgtggag tactactaca   2880

cgtggaaaaa gatcatgcgg ctggggcgga aacaccggac acgcctggca gaaatcatcg   2940

acgattgtgt gacaagtgaa gaagaagaag agttagagga ggaggaggag gaggacccgg   3000

aagaagatag gaaatccaca aaagaagaag agagtgaggt gccgaagtcc ccggagccac   3060

cacccgtccc cgtcctggct cccacggagg ggccgcccct gcaggccctg ggccagccct   3120

caggctcctt catctgtgaa atgcccaact gtggggctgt gttcagctcc cgacaggcac   3180

tgaatggcca tgcccgcatc cacgggggca ccaaccaggt gaccaaggcc cgaggtgcca   3240

tcccctctgg gaagcagaag cctggtggca cccagagtgg gtactgttcg gtaaagagct   3300

caccctctca cagcaccacc agcggcgaga cagaccccac caccatcttc ccctgcaagg   3360

agtgtggcaa agtcttcttc aagatcaaaa gccgaaatgc acacatgaaa actcacaggc   3420

agcaggagga acaacagagg caaaaggctc agaaggcggc ttttgcagct gagatggcag   3480

ccacgattga gaggactacg gggcccgtgg gggcgccggg gctgctgccc ctggaccagc   3540

tgagtctgat caaacccatc aaggatgtgg acatcctcga cgacgacgtc gtccagcagt   3600

tgggaggtgt catggaagag gctgaagttg tggacaccga tcttctcttg gatgatcaag   3660

attcagtctt gcttcagggt gacgcagaac tataaagccc tgtgtgtcac ttagagacag   3720

tgaaaaccca cggcctccat cttcattaat caggaaacct ggactgcctg cttgttttgt   3780

aaccctttta aactacctgt tttaaaagtg gtcattttat tcaggtttag aaaaaaaaat   3840

cctatttctt ttccttttat ttaaaaaaat ttgtttttgt ggggggttgg gggaataaat   3900

aattggcaca actaaaaaaa aaaaa                                         3925


<210>  1788
<211>  956
<212>  PRT
<213>  Homosapiens

<400>  1788

Met Ala Gln Val Leu His Thr Gln Ser Ala Val Met Asp Gly Ala Pro 
1               5                   10                  15      


Asp Ser Ala Leu Arg Gln Leu Leu Ser Gln Lys Pro Met Glu Pro Pro 
            20                  25                  30          


Ala Pro Ala Ile Pro Ser Arg Tyr Gln Gln Val Pro Gln Gln Pro His 
        35                  40                  45              


Pro Gly Phe Thr Gly Gly Leu Ser Lys Pro Ala Leu Gln Val Gly Gln 
    50                  55                  60                  


His Pro Thr Gln Gly His Leu Tyr Tyr Asp Tyr Gln Gln Pro Leu Ala 
65                  70                  75                  80  


Gln Val Pro Val Gln Gly Gly Gln Pro Leu Gln Ala Pro Gln Met Leu 
                85                  90                  95      


Ser Gln His Met Gln Gln Met Gln Gln His Gln Tyr Tyr Pro Pro Gln 
            100                 105                 110         


Gln Gln Gln Gln Ala Gly Gln Gln Arg Ile Ser Met Gln Glu Ile Gln 
        115                 120                 125             


Thr Gln Pro Gln Gln Ile Arg Pro Ser Gln Pro Gln Pro Pro Pro Gln 
    130                 135                 140                 


Gln Gln Gln Pro Gln Gln Leu Gln Leu Gln Gln Arg Gln Gly Ser Met 
145                 150                 155                 160 


Gln Ile Pro Gln Tyr Tyr Gln Pro Gln Pro Met Met Gln His Leu Gln 
                165                 170                 175     


Glu Gln Gln Gln Gln Gln Met His Leu Gln Pro Pro Ser Tyr His Arg 
            180                 185                 190         


Asp Pro His Gln Tyr Thr Pro Glu Gln Ala His Thr Val Gln Leu Ile 
        195                 200                 205             


Pro Leu Gly Ser Met Ser Gln Tyr Tyr Tyr Gln Glu Pro Gln Gln Pro 
    210                 215                 220                 


Tyr Ser His Pro Leu Tyr Gln Gln Ser His Leu Ser Gln His Gln Gln 
225                 230                 235                 240 


Arg Glu Asp Ser Gln Leu Lys Thr Tyr Ser Ser Asp Arg Gln Ala Gln 
                245                 250                 255     


Ala Met Leu Ser Ser His Gly Asp Leu Gly Pro Pro Asp Thr Gly Met 
            260                 265                 270         


Gly Asp Pro Ala Ser Ser Asp Leu Thr Arg Val Ser Ser Thr Leu Pro 
        275                 280                 285             


His Arg Pro Leu Leu Ser Pro Ser Gly Ile His Leu Asn Asn Met Gly 
    290                 295                 300                 


Pro Gln His Gln Gln Leu Ser Pro Ser Ala Met Trp Pro Gln Met His 
305                 310                 315                 320 


Leu Pro Asp Gly Arg Ala Gln Pro Gly Ser Pro Glu Ser Ser Gly Gln 
                325                 330                 335     


Pro Lys Gly Ala Phe Gly Glu Gln Phe Asp Ala Lys Asn Lys Leu Thr 
            340                 345                 350         


Cys Ser Ile Cys Leu Lys Glu Phe Lys Asn Leu Pro Ala Leu Asn Gly 
        355                 360                 365             


His Met Arg Ser His Gly Gly Met Arg Ala Ser Pro Asn Leu Lys Gln 
    370                 375                 380                 


Glu Ile Pro Arg Lys His Gln Pro Ser Val Pro Lys Ala Glu Glu Pro 
385                 390                 395                 400 


Leu Lys Thr Val Gln Glu Lys Lys Lys Phe Arg His Arg Ser Glu Pro 
                405                 410                 415     


Leu Phe Ile Pro Pro Pro Pro Ser Tyr Asn Pro Asn Pro Ala Ala Ser 
            420                 425                 430         


Tyr Ser Gly Ala Thr Leu Tyr Gln Ser Gln Leu Arg Ser Pro Arg Val 
        435                 440                 445             


Leu Gly Asp His Leu Leu Leu Asp Pro Thr His Glu Leu Pro Pro Tyr 
    450                 455                 460                 


Thr Pro Pro Pro Met Leu Ser Pro Val Arg Gln Gly Ser Gly Leu Phe 
465                 470                 475                 480 


Ser Asn Val Leu Ile Ser Gly His Gly Pro Gly Ala His Pro Gln Leu 
                485                 490                 495     


Pro Leu Thr Pro Leu Thr Pro Thr Pro Arg Val Leu Leu Cys Arg Ser 
            500                 505                 510         


Asn Ser Ile Asp Gly Ser Asn Val Thr Val Thr Pro Gly Pro Gly Glu 
        515                 520                 525             


Gln Thr Val Asp Val Glu Pro Arg Ile Asn Ile Gly Leu Arg Phe Gln 
    530                 535                 540                 


Ala Glu Ile Pro Glu Leu Gln Asp Ile Ser Ala Leu Ala Gln Asp Thr 
545                 550                 555                 560 


His Lys Ala Thr Leu Val Trp Lys Pro Trp Pro Glu Leu Glu Asn His 
                565                 570                 575     


Asp Leu Gln Gln Arg Val Glu Asn Leu Leu Asn Leu Cys Cys Ser Ser 
            580                 585                 590         


Ala Leu Pro Gly Gly Gly Thr Asn Ser Glu Phe Ala Leu His Ser Leu 
        595                 600                 605             


Phe Glu Ala Lys Gly Asp Val Met Val Ala Leu Glu Met Leu Leu Leu 
    610                 615                 620                 


Arg Lys Pro Val Arg Leu Lys Cys His Pro Leu Ala Asn Tyr His Tyr 
625                 630                 635                 640 


Ala Gly Ser Asp Lys Trp Thr Ser Leu Glu Arg Lys Leu Phe Asn Lys 
                645                 650                 655     


Ala Leu Ala Thr Tyr Ser Lys Asp Phe Ile Phe Val Gln Lys Met Val 
            660                 665                 670         


Lys Ser Lys Thr Val Ala Gln Cys Val Glu Tyr Tyr Tyr Thr Trp Lys 
        675                 680                 685             


Lys Ile Met Arg Leu Gly Arg Lys His Arg Thr Arg Leu Ala Glu Ile 
    690                 695                 700                 


Ile Asp Asp Cys Val Thr Ser Glu Glu Glu Glu Glu Leu Glu Glu Glu 
705                 710                 715                 720 


Glu Glu Glu Asp Pro Glu Glu Asp Arg Lys Ser Thr Lys Glu Glu Glu 
                725                 730                 735     


Ser Glu Val Pro Lys Ser Pro Glu Pro Pro Pro Val Pro Val Leu Ala 
            740                 745                 750         


Pro Thr Glu Gly Pro Pro Leu Gln Ala Leu Gly Gln Pro Ser Gly Ser 
        755                 760                 765             


Phe Ile Cys Glu Met Pro Asn Cys Gly Ala Val Phe Ser Ser Arg Gln 
    770                 775                 780                 


Ala Leu Asn Gly His Ala Arg Ile His Gly Gly Thr Asn Gln Val Thr 
785                 790                 795                 800 


Lys Ala Arg Gly Ala Ile Pro Ser Gly Lys Gln Lys Pro Gly Gly Thr 
                805                 810                 815     


Gln Ser Gly Tyr Cys Ser Val Lys Ser Ser Pro Ser His Ser Thr Thr 
            820                 825                 830         


Ser Gly Glu Thr Asp Pro Thr Thr Ile Phe Pro Cys Lys Glu Cys Gly 
        835                 840                 845             


Lys Val Phe Phe Lys Ile Lys Ser Arg Asn Ala His Met Lys Thr His 
    850                 855                 860                 


Arg Gln Gln Glu Glu Gln Gln Arg Gln Lys Ala Gln Lys Ala Ala Phe 
865                 870                 875                 880 


Ala Ala Glu Met Ala Ala Thr Ile Glu Arg Thr Thr Gly Pro Val Gly 
                885                 890                 895     


Ala Pro Gly Leu Leu Pro Leu Asp Gln Leu Ser Leu Ile Lys Pro Ile 
            900                 905                 910         


Lys Asp Val Asp Ile Leu Asp Asp Asp Val Val Gln Gln Leu Gly Gly 
        915                 920                 925             


Val Met Glu Glu Ala Glu Val Val Asp Thr Asp Leu Leu Leu Asp Asp 
    930                 935                 940                 


Gln Asp Ser Val Leu Leu Gln Gly Asp Ala Glu Leu 
945                 950                 955     


<210>  1789
<211>  4395
<212>  DNA
<213>  Homosapiens

<400>  1789
ggcgaggatg gggagcaatg caaagctctg ctcgcccccc atctcacccc ccaagcggat     60

actggtcttc tcgtcggatt gcccatgcac ttgttgcaga aacagccaag gccctggctg    120

tggagaatgc tgaaggaaga agacgcagaa gcaggacgac cctgaaagat tcagcctctt    180

catcctcaaa caggaccagg cctcctcttc ccacctgtcc agcagcatga aagcagcatg    240

attggccgac cgcaggagaa gcccccagaa ccaggccccc aactcagcca tctgcggagg    300

tcaaggtgtg agcgacgtct cctcaccaca gtgctgtgtg gtctatacct cagccaggga    360

gaggatgtga aaccccccgc cctgcacatg agtggtacag gccaacagga acacctggct    420

ccagccacgt tcacagacat gtcagccgtg gagtagtgct gacacttttc tctcagcttc    480

tcagggtttc agtccttttg ggtttgtttt atttaccttt tttatggttt tgtggctgga    540

cgttcacaac caaggcagac agcatgggtg accagcaact gtacaagacc aaccatgtgg    600

cccatggtag tgagaacctt ttctaccaac agccaccact tggcgtccac agcgggctga    660

accacaacta tgggaatgca gttacagggg gcggaatgga tgcccctcag gcctcgccaa    720

tctcccccca cttccctcaa gatacacggg atggtctggg cttgcctgtt ggctccaaaa    780

accttggcca aatggatacc tcgaggcagg gagggtgggg aagtcatgca gggcctggaa    840

accatgtcca gctacgtgga aacctggcca actcaaacat gatgtggggg gcaccagccc    900

aggctgagcc cactgatggc taccaataca cctactccca ggccagcgag atccggaccc    960

agaagcttac cagcggtgtc ttacacaagc tggactcttt cacccaggtg tttgccaacc   1020

aaaacctgcg aattcaggtc aacaatatgg cccaggtgct gcacactcag tcagcagtga   1080

tggatggagc ccctgacagt gctctccgcc agctgctgtc tcagaagccc atggagcccc   1140

cagcaccggc tatcccttcc cgctaccagc aggtgcccca gcagcctcac cctggtttca   1200

ctggtgggct gtccaaacca gctcttcagg tcgggcagca ccctacccaa gggcacctgt   1260

attatgacta ccagcagcct ctggctcagg tgccagtgca gggaggacag ccactgcagg   1320

ccccacagat gctgtcacag cacatgcaac agatgcagca gcaccagtat tacccaccgc   1380

agcaacagca gcaagccggg caacagcgta tctccatgca agaaatacag acgcagccgc   1440

aacaaattcg cccatcacag ccacagccgc cgccacagca gcagcagccg cagcagctac   1500

agctgcagca gcggcagggt tcaatgcaga tacctcagta ttatcagccc caacccatga   1560

tgcagcactt gcaagagcag cagcagcaac agatgcacct gcagcctcct tcttatcaca   1620

gggaccctca ccagtatacc ccagagcagg cacacactgt ccagctgatt cccctgggct   1680

ccatgtccca gtactactac caggagcccc agcagcccta cagccacccc ctctaccagc   1740

agagccacct gtcccagcac cagcagcgtg aggacagtca gctgaagacc tactctagtg   1800

acagacaggc ccaggccatg ctgagctccc atggggacct ggggcctcct gacacaggaa   1860

tgggagaccc agcgagctca gatctgaccc gggtcagcag caccctcccc catcgccccc   1920

tcctatcccc cagtgggatc cacctcaaca acatggggcc tcagcatcag cagctgtctc   1980

ccagtgccat gtggccccag atgcacctac ctgatgggag agcccagcca gggtcccctg   2040

agtcaagtgg ccaacccaaa ggagcgtttg gggagcagtt tgatgccaag aacaagctga   2100

catgctccat ctgcctgaag gagttcaaga acctgcctgc cctgaatggc cacatgcggt   2160

cccacggggg aatgagggcc tcccccaacc tcaaacagga ggaaggagag aaggtcctgc   2220

cgcctcagcc ccagccacca ctgccgcctc cgcctccgcc tccgccgcca ccacagctcc   2280

ctcccgaggc agaaagcctc acgcctatgg tcatgcccgt gtctgtccct gtcaagcttc   2340

tcccgcccaa gcccagctct caggggttca ccaacagcac cgttgccgcc ccctccgcca   2400

gagacaagcc agccagctcg atgtcggacg acgagatgcc tgtgctcgaa atccccagga   2460

agcatcagcc gagtgtgccc aaagccgagg agcccctcaa gaccgtgcag gagaagaaaa   2520

agttccggca ccggccggaa cctctcttca tcccgccgcc gccctcctac aacccgaacc   2580

ccgctgcctc ctactcgggc gccaccctgt accagagcca gctgcgctcc ccgcgcgtcc   2640

tcggggacca cctgctcctg gaccccaccc acgagctgcc cccttacacg cccccaccca   2700

tgctgagccc ggtgcgccag ggctcggggc tcttcagcaa tgtcctcatc tccggccacg   2760

gccctggcgc ccacccgcag ctgcccctga cgcccctgac gcccacacca cgggtgctgc   2820

tgtgtcgctc caacagcatc gatggcagca acgtgacggt caccccaggg cctggagagc   2880

agactgtaga tgttgaacca cgcatcaaca ttggcttgag attccaagca gaaatccctg   2940

aactccaaga tatctctgcc ctggcccagg acacacacaa ggccacactg gtatggaagc   3000

cctggccaga actagaaaac catgacctcc agcaaagagt ggagaatctt ctgaatttgt   3060

gctgttccag tgcattgcca ggtggaggga ccaattctga atttgctttg cactctctgt   3120

ttgaggccaa aggtgatgtg atggttgctc tggaaatgct gctactgcgg aagcctgtca   3180

ggttaaaatg tcatccttta gcaaattacc actatgccgg ttcggacaag tggacctccc   3240

tagaaagaaa actgtttaac aaagcactag ccacttacag caaagacttt atttttgtac   3300

agaagatggt gaagtccaag acggtggctc agtgcgtgga gtactactac acgtggaaaa   3360

agatcatgcg gctggggcgg aaacaccgga cacgcctggc agaaatcatc gacgattgtg   3420

tgacaagtga agaagaagaa gagttagagg aggaggagga ggaggacccg gaagaagata   3480

ggaaatccac aaaagaagaa gagagtgagg tgccgaagtc cccggagcca ccacccgtcc   3540

ccgtcctggc tcccacggag gggccgcccc tgcaggccct gggccagccc tcaggctcct   3600

tcatctgtga aatgcccaac tgtggggctg tgttcagctc ccgacaggca ctgaatggcc   3660

atgcccgcat ccacgggggc accaaccagg tgaccaaggc ccgaggtgcc atcccctctg   3720

ggaagcagaa gcctggtggc acccagagtg ggtactgttc ggtaaagagc tcaccctctc   3780

acagcaccac cagcggcgag acagacccca ccaccatctt cccctgcaag gagtgtggca   3840

aagtcttctt caagatcaaa agccgaaatg cacacatgaa aactcacagg cagcaggagg   3900

aacaacagag gcaaaaggct cagaaggcgg cttttgcagc tgagatggca gccacgattg   3960

agaggactac ggggcccgtg ggggcgccgg ggctgctgcc cctggaccag ctgagtctga   4020

tcaaacccat caaggatgtg gacatcctcg acgacgacgt cgtccagcag ttgggaggtg   4080

tcatggaaga ggctgaagtt gtggacaccg atcttctctt ggatgatcaa gattcagtct   4140

tgcttcaggg tgacgcagaa ctataaagcc ctgtgtgtca cttagagaca gtgaaaaccc   4200

acggcctcca tcttcattaa tcaggaaacc tggactgcct gcttgttttg taaccctttt   4260

aaactacctg ttttaaaagt ggtcatttta ttcaggttta gaaaaaaaaa tcctatttct   4320

tttcttttat ttaaaaaaat ttgtttttgt ggggggttgg gggaataaat aattggcaca   4380

actaaaaaaa aaaaa                                                    4395


<210>  1790
<211>  1200
<212>  PRT
<213>  Homosapiens

<400>  1790

Met Gly Asp Gln Gln Leu Tyr Lys Thr Asn His Val Ala His Gly Ser 
1               5                   10                  15      


Glu Asn Leu Phe Tyr Gln Gln Pro Pro Leu Gly Val His Ser Gly Leu 
            20                  25                  30          


Asn His Asn Tyr Gly Asn Ala Val Thr Gly Gly Gly Met Asp Ala Pro 
        35                  40                  45              


Gln Ala Ser Pro Ile Ser Pro His Phe Pro Gln Asp Thr Arg Asp Gly 
    50                  55                  60                  


Leu Gly Leu Pro Val Gly Ser Lys Asn Leu Gly Gln Met Asp Thr Ser 
65                  70                  75                  80  


Arg Gln Gly Gly Trp Gly Ser His Ala Gly Pro Gly Asn His Val Gln 
                85                  90                  95      


Leu Arg Gly Asn Leu Ala Asn Ser Asn Met Met Trp Gly Ala Pro Ala 
            100                 105                 110         


Gln Ala Glu Pro Thr Asp Gly Tyr Gln Tyr Thr Tyr Ser Gln Ala Ser 
        115                 120                 125             


Glu Ile Arg Thr Gln Lys Leu Thr Ser Gly Val Leu His Lys Leu Asp 
    130                 135                 140                 


Ser Phe Thr Gln Val Phe Ala Asn Gln Asn Leu Arg Ile Gln Val Asn 
145                 150                 155                 160 


Asn Met Ala Gln Val Leu His Thr Gln Ser Ala Val Met Asp Gly Ala 
                165                 170                 175     


Pro Asp Ser Ala Leu Arg Gln Leu Leu Ser Gln Lys Pro Met Glu Pro 
            180                 185                 190         


Pro Ala Pro Ala Ile Pro Ser Arg Tyr Gln Gln Val Pro Gln Gln Pro 
        195                 200                 205             


His Pro Gly Phe Thr Gly Gly Leu Ser Lys Pro Ala Leu Gln Val Gly 
    210                 215                 220                 


Gln His Pro Thr Gln Gly His Leu Tyr Tyr Asp Tyr Gln Gln Pro Leu 
225                 230                 235                 240 


Ala Gln Val Pro Val Gln Gly Gly Gln Pro Leu Gln Ala Pro Gln Met 
                245                 250                 255     


Leu Ser Gln His Met Gln Gln Met Gln Gln His Gln Tyr Tyr Pro Pro 
            260                 265                 270         


Gln Gln Gln Gln Gln Ala Gly Gln Gln Arg Ile Ser Met Gln Glu Ile 
        275                 280                 285             


Gln Thr Gln Pro Gln Gln Ile Arg Pro Ser Gln Pro Gln Pro Pro Pro 
    290                 295                 300                 


Gln Gln Gln Gln Pro Gln Gln Leu Gln Leu Gln Gln Arg Gln Gly Ser 
305                 310                 315                 320 


Met Gln Ile Pro Gln Tyr Tyr Gln Pro Gln Pro Met Met Gln His Leu 
                325                 330                 335     


Gln Glu Gln Gln Gln Gln Gln Met His Leu Gln Pro Pro Ser Tyr His 
            340                 345                 350         


Arg Asp Pro His Gln Tyr Thr Pro Glu Gln Ala His Thr Val Gln Leu 
        355                 360                 365             


Ile Pro Leu Gly Ser Met Ser Gln Tyr Tyr Tyr Gln Glu Pro Gln Gln 
    370                 375                 380                 


Pro Tyr Ser His Pro Leu Tyr Gln Gln Ser His Leu Ser Gln His Gln 
385                 390                 395                 400 


Gln Arg Glu Asp Ser Gln Leu Lys Thr Tyr Ser Ser Asp Arg Gln Ala 
                405                 410                 415     


Gln Ala Met Leu Ser Ser His Gly Asp Leu Gly Pro Pro Asp Thr Gly 
            420                 425                 430         


Met Gly Asp Pro Ala Ser Ser Asp Leu Thr Arg Val Ser Ser Thr Leu 
        435                 440                 445             


Pro His Arg Pro Leu Leu Ser Pro Ser Gly Ile His Leu Asn Asn Met 
    450                 455                 460                 


Gly Pro Gln His Gln Gln Leu Ser Pro Ser Ala Met Trp Pro Gln Met 
465                 470                 475                 480 


His Leu Pro Asp Gly Arg Ala Gln Pro Gly Ser Pro Glu Ser Ser Gly 
                485                 490                 495     


Gln Pro Lys Gly Ala Phe Gly Glu Gln Phe Asp Ala Lys Asn Lys Leu 
            500                 505                 510         


Thr Cys Ser Ile Cys Leu Lys Glu Phe Lys Asn Leu Pro Ala Leu Asn 
        515                 520                 525             


Gly His Met Arg Ser His Gly Gly Met Arg Ala Ser Pro Asn Leu Lys 
    530                 535                 540                 


Gln Glu Glu Gly Glu Lys Val Leu Pro Pro Gln Pro Gln Pro Pro Leu 
545                 550                 555                 560 


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Pro Glu Ala 
                565                 570                 575     


Glu Ser Leu Thr Pro Met Val Met Pro Val Ser Val Pro Val Lys Leu 
            580                 585                 590         


Leu Pro Pro Lys Pro Ser Ser Gln Gly Phe Thr Asn Ser Thr Val Ala 
        595                 600                 605             


Ala Pro Ser Ala Arg Asp Lys Pro Ala Ser Ser Met Ser Asp Asp Glu 
    610                 615                 620                 


Met Pro Val Leu Glu Ile Pro Arg Lys His Gln Pro Ser Val Pro Lys 
625                 630                 635                 640 


Ala Glu Glu Pro Leu Lys Thr Val Gln Glu Lys Lys Lys Phe Arg His 
                645                 650                 655     


Arg Pro Glu Pro Leu Phe Ile Pro Pro Pro Pro Ser Tyr Asn Pro Asn 
            660                 665                 670         


Pro Ala Ala Ser Tyr Ser Gly Ala Thr Leu Tyr Gln Ser Gln Leu Arg 
        675                 680                 685             


Ser Pro Arg Val Leu Gly Asp His Leu Leu Leu Asp Pro Thr His Glu 
    690                 695                 700                 


Leu Pro Pro Tyr Thr Pro Pro Pro Met Leu Ser Pro Val Arg Gln Gly 
705                 710                 715                 720 


Ser Gly Leu Phe Ser Asn Val Leu Ile Ser Gly His Gly Pro Gly Ala 
                725                 730                 735     


His Pro Gln Leu Pro Leu Thr Pro Leu Thr Pro Thr Pro Arg Val Leu 
            740                 745                 750         


Leu Cys Arg Ser Asn Ser Ile Asp Gly Ser Asn Val Thr Val Thr Pro 
        755                 760                 765             


Gly Pro Gly Glu Gln Thr Val Asp Val Glu Pro Arg Ile Asn Ile Gly 
    770                 775                 780                 


Leu Arg Phe Gln Ala Glu Ile Pro Glu Leu Gln Asp Ile Ser Ala Leu 
785                 790                 795                 800 


Ala Gln Asp Thr His Lys Ala Thr Leu Val Trp Lys Pro Trp Pro Glu 
                805                 810                 815     


Leu Glu Asn His Asp Leu Gln Gln Arg Val Glu Asn Leu Leu Asn Leu 
            820                 825                 830         


Cys Cys Ser Ser Ala Leu Pro Gly Gly Gly Thr Asn Ser Glu Phe Ala 
        835                 840                 845             


Leu His Ser Leu Phe Glu Ala Lys Gly Asp Val Met Val Ala Leu Glu 
    850                 855                 860                 


Met Leu Leu Leu Arg Lys Pro Val Arg Leu Lys Cys His Pro Leu Ala 
865                 870                 875                 880 


Asn Tyr His Tyr Ala Gly Ser Asp Lys Trp Thr Ser Leu Glu Arg Lys 
                885                 890                 895     


Leu Phe Asn Lys Ala Leu Ala Thr Tyr Ser Lys Asp Phe Ile Phe Val 
            900                 905                 910         


Gln Lys Met Val Lys Ser Lys Thr Val Ala Gln Cys Val Glu Tyr Tyr 
        915                 920                 925             


Tyr Thr Trp Lys Lys Ile Met Arg Leu Gly Arg Lys His Arg Thr Arg 
    930                 935                 940                 


Leu Ala Glu Ile Ile Asp Asp Cys Val Thr Ser Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Leu Glu Glu Glu Glu Glu Glu Asp Pro Glu Glu Asp Arg Lys Ser Thr 
                965                 970                 975     


Lys Glu Glu Glu Ser Glu Val Pro Lys Ser Pro Glu Pro Pro Pro Val 
            980                 985                 990         


Pro Val Leu Ala Pro Thr Glu Gly  Pro Pro Leu Gln Ala  Leu Gly Gln 
        995                 1000                 1005             


Pro Ser  Gly Ser Phe Ile Cys  Glu Met Pro Asn Cys  Gly Ala Val 
    1010                 1015                 1020             


Phe Ser  Ser Arg Gln Ala Leu  Asn Gly His Ala Arg  Ile His Gly 
    1025                 1030                 1035             


Gly Thr  Asn Gln Val Thr Lys  Ala Arg Gly Ala Ile  Pro Ser Gly 
    1040                 1045                 1050             


Lys Gln  Lys Pro Gly Gly Thr  Gln Ser Gly Tyr Cys  Ser Val Lys 
    1055                 1060                 1065             


Ser Ser  Pro Ser His Ser Thr  Thr Ser Gly Glu Thr  Asp Pro Thr 
    1070                 1075                 1080             


Thr Ile  Phe Pro Cys Lys Glu  Cys Gly Lys Val Phe  Phe Lys Ile 
    1085                 1090                 1095             


Lys Ser  Arg Asn Ala His Met  Lys Thr His Arg Gln  Gln Glu Glu 
    1100                 1105                 1110             


Gln Gln  Arg Gln Lys Ala Gln  Lys Ala Ala Phe Ala  Ala Glu Met 
    1115                 1120                 1125             


Ala Ala  Thr Ile Glu Arg Thr  Thr Gly Pro Val Gly  Ala Pro Gly 
    1130                 1135                 1140             


Leu Leu  Pro Leu Asp Gln Leu  Ser Leu Ile Lys Pro  Ile Lys Asp 
    1145                 1150                 1155             


Val Asp  Ile Leu Asp Asp Asp  Val Val Gln Gln Leu  Gly Gly Val 
    1160                 1165                 1170             


Met Glu  Glu Ala Glu Val Val  Asp Thr Asp Leu Leu  Leu Asp Asp 
    1175                 1180                 1185             


Gln Asp  Ser Val Leu Leu Gln  Gly Asp Ala Glu Leu  
    1190                 1195                 1200 


<210>  1791
<211>  3665
<212>  DNA
<213>  Homosapiens

<400>  1791
ggcttggggc agccgggtag ctcggaggtc gtggcgctgg gggctagcac cagcgctctg     60

tcgggaggcg cagcggttag gtggaccggt cagcggactc accggccagg gcgctcggtg    120

ctggaatttg atattcattg atccgggttt tatccctctt cttttttctt aaacattttt    180

ttttaaaact gtattgtttc tcgttttaat ttatttttgc ttgccattcc ccacttgaat    240

cgggccgacg gcttggggag attgctctac ttccccaaat cactgtggat tttggaaacc    300

agcagaaaga ggaaagaggt agcaagagct ccagagagaa gtcgaggaag agagagacgg    360

ggtcagagag agcgcgcggg cgtgcgagca gcgaaagcga caggggcaaa gtgagtgacc    420

tgcttttggg ggtgaccgcc ggagcgcggc gtgagccctc ccccttggga tcccgcagct    480

gaccagtcgc gctgacggac agacagacag acaccgcccc cagccccagc taccacctcc    540

tccccggccg gcggcggaca gtggacgcgg cggcgagccg cgggcagggg ccggagcccg    600

cgcccggagg cggggtggag ggggtcgggg ctcgcggcgt cgcactgaaa cttttcgtcc    660

aacttctggg ctgttctcgc ttcggaggag ccgtggtccg cgcgggggaa gccgagccga    720

gcggagccgc gagaagtgct agctcgggcc gggaggagcc gcagccggag gagggggagg    780

aggaagaaga gaaggaagag gagagggggc cgcagtggcg actcggcgct cggaagccgg    840

gctcatggac gggtgaggcg gcggtgtgcg cagacagtgc tccagccgcg cgcgctcccc    900

aggccctggc ccgggcctcg ggccggggag gaagagtagc tcgccgaggc gccgaggaga    960

gcgggccgcc ccacagcccg agccggagag ggagcgcgag ccgcgccggc cccggtcggg   1020

cctccgaaac catgaacttt ctgctgtctt gggtgcattg gagccttgcc ttgctgctct   1080

acctccacca tgccaagtgg tcccaggctg cacccatggc agaaggagga gggcagaatc   1140

atcacgaagt ggtgaagttc atggatgtct atcagcgcag ctactgccat ccaatcgaga   1200

ccctggtgga catcttccag gagtaccctg atgagatcga gtacatcttc aagccatcct   1260

gtgtgcccct gatgcgatgc gggggctgct gcaatgacga gggcctggag tgtgtgccca   1320

ctgaggagtc caacatcacc atgcagatta tgcggatcaa acctcaccaa ggccagcaca   1380

taggagagat gagcttccta cagcacaaca aatgtgaatg cagaccaaag aaagatagag   1440

caagacaaga aaaaaaatca gttcgaggaa agggaaaggg gcaaaaacga aagcgcaaga   1500

aatcccggta taagtcctgg agcgtgtacg ttggtgcccg ctgctgtcta atgccctgga   1560

gcctccctgg cccccatccc tgtgggcctt gctcagagcg gagaaagcat ttgtttgtac   1620

aagatccgca gacgtgtaaa tgttcctgca aaaacacaga ctcgcgttgc aaggcgaggc   1680

agcttgagtt aaacgaacgt acttgcagat gtgacaagcc gaggcggtga gccgggcagg   1740

aggaaggagc ctccctcagg gtttcgggaa ccagatctct caccaggaaa gactgataca   1800

gaacgatcga tacagaaacc acgctgccgc caccacacca tcaccatcga cagaacagtc   1860

cttaatccag aaacctgaaa tgaaggaaga ggagactctg cgcagagcac tttgggtccg   1920

gagggcgaga ctccggcgga agcattcccg ggcgggtgac ccagcacggt ccctcttgga   1980

attggattcg ccattttatt tttcttgctg ctaaatcacc gagcccggaa gattagagag   2040

ttttatttct gggattcctg tagacacacc cacccacata catacattta tatatatata   2100

tattatatat atataaaaat aaatatctct attttatata tataaaatat atatattctt   2160

tttttaaatt aacagtgcta atgttattgg tgtcttcact ggatgtattt gactgctgtg   2220

gacttgagtt gggaggggaa tgttcccact cagatcctga cagggaagag gaggagatga   2280

gagactctgg catgatcttt tttttgtccc acttggtggg gccagggtcc tctcccctgc   2340

ccaggaatgt gcaaggccag ggcatggggg caaatatgac ccagttttgg gaacaccgac   2400

aaacccagcc ctggcgctga gcctctctac cccaggtcag acggacagaa agacagatca   2460

caggtacagg gatgaggaca ccggctctga ccaggagttt ggggagcttc aggacattgc   2520

tgtgctttgg ggattccctc cacatgctgc acgcgcatct cgcccccagg ggcactgcct   2580

ggaagattca ggagcctggg cggccttcgc ttactctcac ctgcttctga gttgcccagg   2640

agaccactgg cagatgtccc ggcgaagaga agagacacat tgttggaaga agcagcccat   2700

gacagctccc cttcctggga ctcgccctca tcctcttcct gctccccttc ctggggtgca   2760

gcctaaaagg acctatgtcc tcacaccatt gaaaccacta gttctgtccc cccaggagac   2820

ctggttgtgt gtgtgtgagt ggttgacctt cctccatccc ctggtccttc ccttcccttc   2880

ccgaggcaca gagagacagg gcaggatcca cgtgcccatt gtggaggcag agaaaagaga   2940

aagtgtttta tatacggtac ttatttaata tcccttttta attagaaatt aaaacagtta   3000

atttaattaa agagtagggt tttttttcag tattcttggt taatatttaa tttcaactat   3060

ttatgagatg tatcttttgc tctctcttgc tctcttattt gtaccggttt ttgtatataa   3120

aattcatgtt tccaatctct ctctccctga tcggtgacag tcactagctt atcttgaaca   3180

gatatttaat tttgctaaca ctcagctctg ccctccccga tcccctggct ccccagcaca   3240

cattcctttg aaataaggtt tcaatataca tctacatact atatatatat ttggcaactt   3300

gtatttgtgt gtatatatat atatatatgt ttatgtatat atgtgattct gataaaatag   3360

acattgctat tctgtttttt atatgtaaaa acaaaacaag aaaaaataga gaattctaca   3420

tactaaatct ctctcctttt ttaattttaa tatttgttat catttattta ttggtgctac   3480

tgtttatccg taataattgt ggggaaaaga tattaacatc acgtctttgt ctctagtgca   3540

gtttttcgag atattccgta gtacatattt atttttaaac aacgacaaag aaatacagat   3600

atatcttaaa aaaaaaaaag cattttgtat taaagaattt aattctgatc tcaaaaaaaa   3660

aaaaa                                                               3665


<210>  1792
<211>  412
<212>  PRT
<213>  Homosapiens

<400>  1792

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys 
            340                 345                 350         


Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser 
        355                 360                 365             


Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys 
    370                 375                 380                 


Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu 
385                 390                 395                 400 


Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
                405                 410         


<210>  1793
<211>  3596
<212>  DNA
<213>  Homosapiens

<400>  1793
ggcttggggc agccgggtag ctcggaggtc gtggcgctgg gggctagcac cagcgctctg     60

tcgggaggcg cagcggttag gtggaccggt cagcggactc accggccagg gcgctcggtg    120

ctggaatttg atattcattg atccgggttt tatccctctt cttttttctt aaacattttt    180

ttttaaaact gtattgtttc tcgttttaat ttatttttgc ttgccattcc ccacttgaat    240

cgggccgacg gcttggggag attgctctac ttccccaaat cactgtggat tttggaaacc    300

agcagaaaga ggaaagaggt agcaagagct ccagagagaa gtcgaggaag agagagacgg    360

ggtcagagag agcgcgcggg cgtgcgagca gcgaaagcga caggggcaaa gtgagtgacc    420

tgcttttggg ggtgaccgcc ggagcgcggc gtgagccctc ccccttggga tcccgcagct    480

gaccagtcgc gctgacggac agacagacag acaccgcccc cagccccagc taccacctcc    540

tccccggccg gcggcggaca gtggacgcgg cggcgagccg cgggcagggg ccggagcccg    600

cgcccggagg cggggtggag ggggtcgggg ctcgcggcgt cgcactgaaa cttttcgtcc    660

aacttctggg ctgttctcgc ttcggaggag ccgtggtccg cgcgggggaa gccgagccga    720

gcggagccgc gagaagtgct agctcgggcc gggaggagcc gcagccggag gagggggagg    780

aggaagaaga gaaggaagag gagagggggc cgcagtggcg actcggcgct cggaagccgg    840

gctcatggac gggtgaggcg gcggtgtgcg cagacagtgc tccagccgcg cgcgctcccc    900

aggccctggc ccgggcctcg ggccggggag gaagagtagc tcgccgaggc gccgaggaga    960

gcgggccgcc ccacagcccg agccggagag ggagcgcgag ccgcgccggc cccggtcggg   1020

cctccgaaac catgaacttt ctgctgtctt gggtgcattg gagccttgcc ttgctgctct   1080

acctccacca tgccaagtgg tcccaggctg cacccatggc agaaggagga gggcagaatc   1140

atcacgaagt ggtgaagttc atggatgtct atcagcgcag ctactgccat ccaatcgaga   1200

ccctggtgga catcttccag gagtaccctg atgagatcga gtacatcttc aagccatcct   1260

gtgtgcccct gatgcgatgc gggggctgct gcaatgacga gggcctggag tgtgtgccca   1320

ctgaggagtc caacatcacc atgcagatta tgcggatcaa acctcaccaa ggccagcaca   1380

taggagagat gagcttccta cagcacaaca aatgtgaatg cagaccaaag aaagatagag   1440

caagacaaga aaaaaaatca gttcgaggaa agggaaaggg gcaaaaacga aagcgcaaga   1500

aatcccgtcc ctgtgggcct tgctcagagc ggagaaagca tttgtttgta caagatccgc   1560

agacgtgtaa atgttcctgc aaaaacacag actcgcgttg caaggcgagg cagcttgagt   1620

taaacgaacg tacttgcaga tgtgacaagc cgaggcggtg agccgggcag gaggaaggag   1680

cctccctcag ggtttcggga accagatctc tcaccaggaa agactgatac agaacgatcg   1740

atacagaaac cacgctgccg ccaccacacc atcaccatcg acagaacagt ccttaatcca   1800

gaaacctgaa atgaaggaag aggagactct gcgcagagca ctttgggtcc ggagggcgag   1860

actccggcgg aagcattccc gggcgggtga cccagcacgg tccctcttgg aattggattc   1920

gccattttat ttttcttgct gctaaatcac cgagcccgga agattagaga gttttatttc   1980

tgggattcct gtagacacac ccacccacat acatacattt atatatatat atattatata   2040

tatataaaaa taaatatctc tattttatat atataaaata tatatattct ttttttaaat   2100

taacagtgct aatgttattg gtgtcttcac tggatgtatt tgactgctgt ggacttgagt   2160

tgggagggga atgttcccac tcagatcctg acagggaaga ggaggagatg agagactctg   2220

gcatgatctt ttttttgtcc cacttggtgg ggccagggtc ctctcccctg cccaggaatg   2280

tgcaaggcca gggcatgggg gcaaatatga cccagttttg ggaacaccga caaacccagc   2340

cctggcgctg agcctctcta ccccaggtca gacggacaga aagacagatc acaggtacag   2400

ggatgaggac accggctctg accaggagtt tggggagctt caggacattg ctgtgctttg   2460

gggattccct ccacatgctg cacgcgcatc tcgcccccag gggcactgcc tggaagattc   2520

aggagcctgg gcggccttcg cttactctca cctgcttctg agttgcccag gagaccactg   2580

gcagatgtcc cggcgaagag aagagacaca ttgttggaag aagcagccca tgacagctcc   2640

ccttcctggg actcgccctc atcctcttcc tgctcccctt cctggggtgc agcctaaaag   2700

gacctatgtc ctcacaccat tgaaaccact agttctgtcc ccccaggaga cctggttgtg   2760

tgtgtgtgag tggttgacct tcctccatcc cctggtcctt cccttccctt cccgaggcac   2820

agagagacag ggcaggatcc acgtgcccat tgtggaggca gagaaaagag aaagtgtttt   2880

atatacggta cttatttaat atcccttttt aattagaaat taaaacagtt aatttaatta   2940

aagagtaggg ttttttttca gtattcttgg ttaatattta atttcaacta tttatgagat   3000

gtatcttttg ctctctcttg ctctcttatt tgtaccggtt tttgtatata aaattcatgt   3060

ttccaatctc tctctccctg atcggtgaca gtcactagct tatcttgaac agatatttaa   3120

ttttgctaac actcagctct gccctccccg atcccctggc tccccagcac acattccttt   3180

gaaataaggt ttcaatatac atctacatac tatatatata tttggcaact tgtatttgtg   3240

tgtatatata tatatatatg tttatgtata tatgtgattc tgataaaata gacattgcta   3300

ttctgttttt tatatgtaaa aacaaaacaa gaaaaaatag agaattctac atactaaatc   3360

tctctccttt tttaatttta atatttgtta tcatttattt attggtgcta ctgtttatcc   3420

gtaataattg tggggaaaag atattaacat cacgtctttg tctctagtgc agtttttcga   3480

gatattccgt agtacatatt tatttttaaa caacgacaaa gaaatacaga tatatcttaa   3540

aaaaaaaaaa gcattttgta ttaaagaatt taattctgat ctcaaaaaaa aaaaaa       3596


<210>  1794
<211>  389
<212>  PRT
<213>  Homosapiens

<400>  1794

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe 
            340                 345                 350         


Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser 
        355                 360                 365             


Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys 
    370                 375                 380                 


Asp Lys Pro Arg Arg 
385                 


<210>  1795
<211>  3542
<212>  DNA
<213>  Homosapiens

<400>  1795
ggcttggggc agccgggtag ctcggaggtc gtggcgctgg gggctagcac cagcgctctg     60

tcgggaggcg cagcggttag gtggaccggt cagcggactc accggccagg gcgctcggtg    120

ctggaatttg atattcattg atccgggttt tatccctctt cttttttctt aaacattttt    180

ttttaaaact gtattgtttc tcgttttaat ttatttttgc ttgccattcc ccacttgaat    240

cgggccgacg gcttggggag attgctctac ttccccaaat cactgtggat tttggaaacc    300

agcagaaaga ggaaagaggt agcaagagct ccagagagaa gtcgaggaag agagagacgg    360

ggtcagagag agcgcgcggg cgtgcgagca gcgaaagcga caggggcaaa gtgagtgacc    420

tgcttttggg ggtgaccgcc ggagcgcggc gtgagccctc ccccttggga tcccgcagct    480

gaccagtcgc gctgacggac agacagacag acaccgcccc cagccccagc taccacctcc    540

tccccggccg gcggcggaca gtggacgcgg cggcgagccg cgggcagggg ccggagcccg    600

cgcccggagg cggggtggag ggggtcgggg ctcgcggcgt cgcactgaaa cttttcgtcc    660

aacttctggg ctgttctcgc ttcggaggag ccgtggtccg cgcgggggaa gccgagccga    720

gcggagccgc gagaagtgct agctcgggcc gggaggagcc gcagccggag gagggggagg    780

aggaagaaga gaaggaagag gagagggggc cgcagtggcg actcggcgct cggaagccgg    840

gctcatggac gggtgaggcg gcggtgtgcg cagacagtgc tccagccgcg cgcgctcccc    900

aggccctggc ccgggcctcg ggccggggag gaagagtagc tcgccgaggc gccgaggaga    960

gcgggccgcc ccacagcccg agccggagag ggagcgcgag ccgcgccggc cccggtcggg   1020

cctccgaaac catgaacttt ctgctgtctt gggtgcattg gagccttgcc ttgctgctct   1080

acctccacca tgccaagtgg tcccaggctg cacccatggc agaaggagga gggcagaatc   1140

atcacgaagt ggtgaagttc atggatgtct atcagcgcag ctactgccat ccaatcgaga   1200

ccctggtgga catcttccag gagtaccctg atgagatcga gtacatcttc aagccatcct   1260

gtgtgcccct gatgcgatgc gggggctgct gcaatgacga gggcctggag tgtgtgccca   1320

ctgaggagtc caacatcacc atgcagatta tgcggatcaa acctcaccaa ggccagcaca   1380

taggagagat gagcttccta cagcacaaca aatgtgaatg cagaccaaag aaagatagag   1440

caagacaaga aaatccctgt gggccttgct cagagcggag aaagcatttg tttgtacaag   1500

atccgcagac gtgtaaatgt tcctgcaaaa acacagactc gcgttgcaag gcgaggcagc   1560

ttgagttaaa cgaacgtact tgcagatgtg acaagccgag gcggtgagcc gggcaggagg   1620

aaggagcctc cctcagggtt tcgggaacca gatctctcac caggaaagac tgatacagaa   1680

cgatcgatac agaaaccacg ctgccgccac cacaccatca ccatcgacag aacagtcctt   1740

aatccagaaa cctgaaatga aggaagagga gactctgcgc agagcacttt gggtccggag   1800

ggcgagactc cggcggaagc attcccgggc gggtgaccca gcacggtccc tcttggaatt   1860

ggattcgcca ttttattttt cttgctgcta aatcaccgag cccggaagat tagagagttt   1920

tatttctggg attcctgtag acacacccac ccacatacat acatttatat atatatatat   1980

tatatatata taaaaataaa tatctctatt ttatatatat aaaatatata tattcttttt   2040

ttaaattaac agtgctaatg ttattggtgt cttcactgga tgtatttgac tgctgtggac   2100

ttgagttggg aggggaatgt tcccactcag atcctgacag ggaagaggag gagatgagag   2160

actctggcat gatctttttt ttgtcccact tggtggggcc agggtcctct cccctgccca   2220

ggaatgtgca aggccagggc atgggggcaa atatgaccca gttttgggaa caccgacaaa   2280

cccagccctg gcgctgagcc tctctacccc aggtcagacg gacagaaaga cagatcacag   2340

gtacagggat gaggacaccg gctctgacca ggagtttggg gagcttcagg acattgctgt   2400

gctttgggga ttccctccac atgctgcacg cgcatctcgc ccccaggggc actgcctgga   2460

agattcagga gcctgggcgg ccttcgctta ctctcacctg cttctgagtt gcccaggaga   2520

ccactggcag atgtcccggc gaagagaaga gacacattgt tggaagaagc agcccatgac   2580

agctcccctt cctgggactc gccctcatcc tcttcctgct ccccttcctg gggtgcagcc   2640

taaaaggacc tatgtcctca caccattgaa accactagtt ctgtcccccc aggagacctg   2700

gttgtgtgtg tgtgagtggt tgaccttcct ccatcccctg gtccttccct tcccttcccg   2760

aggcacagag agacagggca ggatccacgt gcccattgtg gaggcagaga aaagagaaag   2820

tgttttatat acggtactta tttaatatcc ctttttaatt agaaattaaa acagttaatt   2880

taattaaaga gtagggtttt ttttcagtat tcttggttaa tatttaattt caactattta   2940

tgagatgtat cttttgctct ctcttgctct cttatttgta ccggtttttg tatataaaat   3000

tcatgtttcc aatctctctc tccctgatcg gtgacagtca ctagcttatc ttgaacagat   3060

atttaatttt gctaacactc agctctgccc tccccgatcc cctggctccc cagcacacat   3120

tcctttgaaa taaggtttca atatacatct acatactata tatatatttg gcaacttgta   3180

tttgtgtgta tatatatata tatatgttta tgtatatatg tgattctgat aaaatagaca   3240

ttgctattct gttttttata tgtaaaaaca aaacaagaaa aaatagagaa ttctacatac   3300

taaatctctc tcctttttta attttaatat ttgttatcat ttatttattg gtgctactgt   3360

ttatccgtaa taattgtggg gaaaagatat taacatcacg tctttgtctc tagtgcagtt   3420

tttcgagata ttccgtagta catatttatt tttaaacaac gacaaagaaa tacagatata   3480

tcttaaaaaa aaaaaagcat tttgtattaa agaatttaat tctgatctca aaaaaaaaaa   3540

aa                                                                  3542


<210>  1796
<211>  371
<212>  PRT
<213>  Homosapiens

<400>  1796

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 
                325                 330                 335     


Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 
            340                 345                 350         


Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys 
        355                 360                 365             


Pro Arg Arg 
    370     


<210>  1797
<211>  3507
<212>  DNA
<213>  Homosapiens

<400>  1797
ggcttggggc agccgggtag ctcggaggtc gtggcgctgg gggctagcac cagcgctctg     60

tcgggaggcg cagcggttag gtggaccggt cagcggactc accggccagg gcgctcggtg    120

ctggaatttg atattcattg atccgggttt tatccctctt cttttttctt aaacattttt    180

ttttaaaact gtattgtttc tcgttttaat ttatttttgc ttgccattcc ccacttgaat    240

cgggccgacg gcttggggag attgctctac ttccccaaat cactgtggat tttggaaacc    300

agcagaaaga ggaaagaggt agcaagagct ccagagagaa gtcgaggaag agagagacgg    360

ggtcagagag agcgcgcggg cgtgcgagca gcgaaagcga caggggcaaa gtgagtgacc    420

tgcttttggg ggtgaccgcc ggagcgcggc gtgagccctc ccccttggga tcccgcagct    480

gaccagtcgc gctgacggac agacagacag acaccgcccc cagccccagc taccacctcc    540

tccccggccg gcggcggaca gtggacgcgg cggcgagccg cgggcagggg ccggagcccg    600

cgcccggagg cggggtggag ggggtcgggg ctcgcggcgt cgcactgaaa cttttcgtcc    660

aacttctggg ctgttctcgc ttcggaggag ccgtggtccg cgcgggggaa gccgagccga    720

gcggagccgc gagaagtgct agctcgggcc gggaggagcc gcagccggag gagggggagg    780

aggaagaaga gaaggaagag gagagggggc cgcagtggcg actcggcgct cggaagccgg    840

gctcatggac gggtgaggcg gcggtgtgcg cagacagtgc tccagccgcg cgcgctcccc    900

aggccctggc ccgggcctcg ggccggggag gaagagtagc tcgccgaggc gccgaggaga    960

gcgggccgcc ccacagcccg agccggagag ggagcgcgag ccgcgccggc cccggtcggg   1020

cctccgaaac catgaacttt ctgctgtctt gggtgcattg gagccttgcc ttgctgctct   1080

acctccacca tgccaagtgg tcccaggctg cacccatggc agaaggagga gggcagaatc   1140

atcacgaagt ggtgaagttc atggatgtct atcagcgcag ctactgccat ccaatcgaga   1200

ccctggtgga catcttccag gagtaccctg atgagatcga gtacatcttc aagccatcct   1260

gtgtgcccct gatgcgatgc gggggctgct gcaatgacga gggcctggag tgtgtgccca   1320

ctgaggagtc caacatcacc atgcagatta tgcggatcaa acctcaccaa ggccagcaca   1380

taggagagat gagcttccta cagcacaaca aatgtgaatg cagaccaaag aaagatagag   1440

caagacaaga aaatccctgt gggccttgct cagagcggag aaagcatttg tttgtacaag   1500

atccgcagac gtgtaaatgt tcctgcaaaa acacagactc gcgttgcaag atgtgacaag   1560

ccgaggcggt gagccgggca ggaggaagga gcctccctca gggtttcggg aaccagatct   1620

ctcaccagga aagactgata cagaacgatc gatacagaaa ccacgctgcc gccaccacac   1680

catcaccatc gacagaacag tccttaatcc agaaacctga aatgaaggaa gaggagactc   1740

tgcgcagagc actttgggtc cggagggcga gactccggcg gaagcattcc cgggcgggtg   1800

acccagcacg gtccctcttg gaattggatt cgccatttta tttttcttgc tgctaaatca   1860

ccgagcccgg aagattagag agttttattt ctgggattcc tgtagacaca cccacccaca   1920

tacatacatt tatatatata tatattatat atatataaaa ataaatatct ctattttata   1980

tatataaaat atatatattc tttttttaaa ttaacagtgc taatgttatt ggtgtcttca   2040

ctggatgtat ttgactgctg tggacttgag ttgggagggg aatgttccca ctcagatcct   2100

gacagggaag aggaggagat gagagactct ggcatgatct tttttttgtc ccacttggtg   2160

gggccagggt cctctcccct gcccaggaat gtgcaaggcc agggcatggg ggcaaatatg   2220

acccagtttt gggaacaccg acaaacccag ccctggcgct gagcctctct accccaggtc   2280

agacggacag aaagacagat cacaggtaca gggatgagga caccggctct gaccaggagt   2340

ttggggagct tcaggacatt gctgtgcttt ggggattccc tccacatgct gcacgcgcat   2400

ctcgccccca ggggcactgc ctggaagatt caggagcctg ggcggccttc gcttactctc   2460

acctgcttct gagttgccca ggagaccact ggcagatgtc ccggcgaaga gaagagacac   2520

attgttggaa gaagcagccc atgacagctc cccttcctgg gactcgccct catcctcttc   2580

ctgctcccct tcctggggtg cagcctaaaa ggacctatgt cctcacacca ttgaaaccac   2640

tagttctgtc cccccaggag acctggttgt gtgtgtgtga gtggttgacc ttcctccatc   2700

ccctggtcct tcccttccct tcccgaggca cagagagaca gggcaggatc cacgtgccca   2760

ttgtggaggc agagaaaaga gaaagtgttt tatatacggt acttatttaa tatccctttt   2820

taattagaaa ttaaaacagt taatttaatt aaagagtagg gttttttttc agtattcttg   2880

gttaatattt aatttcaact atttatgaga tgtatctttt gctctctctt gctctcttat   2940

ttgtaccggt ttttgtatat aaaattcatg tttccaatct ctctctccct gatcggtgac   3000

agtcactagc ttatcttgaa cagatattta attttgctaa cactcagctc tgccctcccc   3060

gatcccctgg ctccccagca cacattcctt tgaaataagg tttcaatata catctacata   3120

ctatatatat atttggcaac ttgtatttgt gtgtatatat atatatatat gtttatgtat   3180

atatgtgatt ctgataaaat agacattgct attctgtttt ttatatgtaa aaacaaaaca   3240

agaaaaaata gagaattcta catactaaat ctctctcctt ttttaatttt aatatttgtt   3300

atcatttatt tattggtgct actgtttatc cgtaataatt gtggggaaaa gatattaaca   3360

tcacgtcttt gtctctagtg cagtttttcg agatattccg tagtacatat ttatttttaa   3420

acaacgacaa agaaatacag atatatctta aaaaaaaaaa agcattttgt attaaagaat   3480

ttaattctga tctcaaaaaa aaaaaaa                                       3507


<210>  1798
<211>  354
<212>  PRT
<213>  Homosapiens

<400>  1798

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 
                325                 330                 335     


Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 
            340                 345                 350         


Lys Met 
        


<210>  1799
<211>  3410
<212>  DNA
<213>  Homosapiens

<400>  1799
ggcttggggc agccgggtag ctcggaggtc gtggcgctgg gggctagcac cagcgctctg     60

tcgggaggcg cagcggttag gtggaccggt cagcggactc accggccagg gcgctcggtg    120

ctggaatttg atattcattg atccgggttt tatccctctt cttttttctt aaacattttt    180

ttttaaaact gtattgtttc tcgttttaat ttatttttgc ttgccattcc ccacttgaat    240

cgggccgacg gcttggggag attgctctac ttccccaaat cactgtggat tttggaaacc    300

agcagaaaga ggaaagaggt agcaagagct ccagagagaa gtcgaggaag agagagacgg    360

ggtcagagag agcgcgcggg cgtgcgagca gcgaaagcga caggggcaaa gtgagtgacc    420

tgcttttggg ggtgaccgcc ggagcgcggc gtgagccctc ccccttggga tcccgcagct    480

gaccagtcgc gctgacggac agacagacag acaccgcccc cagccccagc taccacctcc    540

tccccggccg gcggcggaca gtggacgcgg cggcgagccg cgggcagggg ccggagcccg    600

cgcccggagg cggggtggag ggggtcgggg ctcgcggcgt cgcactgaaa cttttcgtcc    660

aacttctggg ctgttctcgc ttcggaggag ccgtggtccg cgcgggggaa gccgagccga    720

gcggagccgc gagaagtgct agctcgggcc gggaggagcc gcagccggag gagggggagg    780

aggaagaaga gaaggaagag gagagggggc cgcagtggcg actcggcgct cggaagccgg    840

gctcatggac gggtgaggcg gcggtgtgcg cagacagtgc tccagccgcg cgcgctcccc    900

aggccctggc ccgggcctcg ggccggggag gaagagtagc tcgccgaggc gccgaggaga    960

gcgggccgcc ccacagcccg agccggagag ggagcgcgag ccgcgccggc cccggtcggg   1020

cctccgaaac catgaacttt ctgctgtctt gggtgcattg gagccttgcc ttgctgctct   1080

acctccacca tgccaagtgg tcccaggctg cacccatggc agaaggagga gggcagaatc   1140

atcacgaagt ggtgaagttc atggatgtct atcagcgcag ctactgccat ccaatcgaga   1200

ccctggtgga catcttccag gagtaccctg atgagatcga gtacatcttc aagccatcct   1260

gtgtgcccct gatgcgatgc gggggctgct gcaatgacga gggcctggag tgtgtgccca   1320

ctgaggagtc caacatcacc atgcagatta tgcggatcaa acctcaccaa ggccagcaca   1380

taggagagat gagcttccta cagcacaaca aatgtgaatg cagaccaaag aaagatagag   1440

caagacaaga aaaatgtgac aagccgaggc ggtgagccgg gcaggaggaa ggagcctccc   1500

tcagggtttc gggaaccaga tctctcacca ggaaagactg atacagaacg atcgatacag   1560

aaaccacgct gccgccacca caccatcacc atcgacagaa cagtccttaa tccagaaacc   1620

tgaaatgaag gaagaggaga ctctgcgcag agcactttgg gtccggaggg cgagactccg   1680

gcggaagcat tcccgggcgg gtgacccagc acggtccctc ttggaattgg attcgccatt   1740

ttatttttct tgctgctaaa tcaccgagcc cggaagatta gagagtttta tttctgggat   1800

tcctgtagac acacccaccc acatacatac atttatatat atatatatta tatatatata   1860

aaaataaata tctctatttt atatatataa aatatatata ttcttttttt aaattaacag   1920

tgctaatgtt attggtgtct tcactggatg tatttgactg ctgtggactt gagttgggag   1980

gggaatgttc ccactcagat cctgacaggg aagaggagga gatgagagac tctggcatga   2040

tctttttttt gtcccacttg gtggggccag ggtcctctcc cctgcccagg aatgtgcaag   2100

gccagggcat gggggcaaat atgacccagt tttgggaaca ccgacaaacc cagccctggc   2160

gctgagcctc tctaccccag gtcagacgga cagaaagaca gatcacaggt acagggatga   2220

ggacaccggc tctgaccagg agtttgggga gcttcaggac attgctgtgc tttggggatt   2280

ccctccacat gctgcacgcg catctcgccc ccaggggcac tgcctggaag attcaggagc   2340

ctgggcggcc ttcgcttact ctcacctgct tctgagttgc ccaggagacc actggcagat   2400

gtcccggcga agagaagaga cacattgttg gaagaagcag cccatgacag ctccccttcc   2460

tgggactcgc cctcatcctc ttcctgctcc ccttcctggg gtgcagccta aaaggaccta   2520

tgtcctcaca ccattgaaac cactagttct gtccccccag gagacctggt tgtgtgtgtg   2580

tgagtggttg accttcctcc atcccctggt ccttcccttc ccttcccgag gcacagagag   2640

acagggcagg atccacgtgc ccattgtgga ggcagagaaa agagaaagtg ttttatatac   2700

ggtacttatt taatatccct ttttaattag aaattaaaac agttaattta attaaagagt   2760

agggtttttt ttcagtattc ttggttaata tttaatttca actatttatg agatgtatct   2820

tttgctctct cttgctctct tatttgtacc ggtttttgta tataaaattc atgtttccaa   2880

tctctctctc cctgatcggt gacagtcact agcttatctt gaacagatat ttaattttgc   2940

taacactcag ctctgccctc cccgatcccc tggctcccca gcacacattc ctttgaaata   3000

aggtttcaat atacatctac atactatata tatatttggc aacttgtatt tgtgtgtata   3060

tatatatata tatgtttatg tatatatgtg attctgataa aatagacatt gctattctgt   3120

tttttatatg taaaaacaaa acaagaaaaa atagagaatt ctacatacta aatctctctc   3180

cttttttaat tttaatattt gttatcattt atttattggt gctactgttt atccgtaata   3240

attgtgggga aaagatatta acatcacgtc tttgtctcta gtgcagtttt tcgagatatt   3300

ccgtagtaca tatttatttt taaacaacga caaagaaata cagatatatc ttaaaaaaaa   3360

aaaagcattt tgtattaaag aatttaattc tgatctcaaa aaaaaaaaaa              3410


<210>  1800
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  1800

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Cys Asp Lys Pro Arg Arg 
                325         


<210>  1801
<211>  3476
<212>  DNA
<213>  Homosapiens

<400>  1801
ggcttggggc agccgggtag ctcggaggtc gtggcgctgg gggctagcac cagcgctctg     60

tcgggaggcg cagcggttag gtggaccggt cagcggactc accggccagg gcgctcggtg    120

ctggaatttg atattcattg atccgggttt tatccctctt cttttttctt aaacattttt    180

ttttaaaact gtattgtttc tcgttttaat ttatttttgc ttgccattcc ccacttgaat    240

cgggccgacg gcttggggag attgctctac ttccccaaat cactgtggat tttggaaacc    300

agcagaaaga ggaaagaggt agcaagagct ccagagagaa gtcgaggaag agagagacgg    360

ggtcagagag agcgcgcggg cgtgcgagca gcgaaagcga caggggcaaa gtgagtgacc    420

tgcttttggg ggtgaccgcc ggagcgcggc gtgagccctc ccccttggga tcccgcagct    480

gaccagtcgc gctgacggac agacagacag acaccgcccc cagccccagc taccacctcc    540

tccccggccg gcggcggaca gtggacgcgg cggcgagccg cgggcagggg ccggagcccg    600

cgcccggagg cggggtggag ggggtcgggg ctcgcggcgt cgcactgaaa cttttcgtcc    660

aacttctggg ctgttctcgc ttcggaggag ccgtggtccg cgcgggggaa gccgagccga    720

gcggagccgc gagaagtgct agctcgggcc gggaggagcc gcagccggag gagggggagg    780

aggaagaaga gaaggaagag gagagggggc cgcagtggcg actcggcgct cggaagccgg    840

gctcatggac gggtgaggcg gcggtgtgcg cagacagtgc tccagccgcg cgcgctcccc    900

aggccctggc ccgggcctcg ggccggggag gaagagtagc tcgccgaggc gccgaggaga    960

gcgggccgcc ccacagcccg agccggagag ggagcgcgag ccgcgccggc cccggtcggg   1020

cctccgaaac catgaacttt ctgctgtctt gggtgcattg gagccttgcc ttgctgctct   1080

acctccacca tgccaagtgg tcccaggctg cacccatggc agaaggagga gggcagaatc   1140

atcacgaagt ggtgaagttc atggatgtct atcagcgcag ctactgccat ccaatcgaga   1200

ccctggtgga catcttccag gagtaccctg atgagatcga gtacatcttc aagccatcct   1260

gtgtgcccct gatgcgatgc gggggctgct gcaatgacga gggcctggag tgtgtgccca   1320

ctgaggagtc caacatcacc atgcagatta tgcggatcaa acctcaccaa ggccagcaca   1380

taggagagat gagcttccta cagcacaaca aatgtgaatg cagaccaaag aaagatagag   1440

caagacaaga aaatccctgt gggccttgct cagagcggag aaagcatttg tttgtacaag   1500

atccgcagac gtgtaaatgt tcctgcaaaa acacagactc gcgttgcaag gcgaggcagc   1560

ttgagttaaa cgaacgtact tgcagatctc tcaccaggaa agactgatac agaacgatcg   1620

atacagaaac cacgctgccg ccaccacacc atcaccatcg acagaacagt ccttaatcca   1680

gaaacctgaa atgaaggaag aggagactct gcgcagagca ctttgggtcc ggagggcgag   1740

actccggcgg aagcattccc gggcgggtga cccagcacgg tccctcttgg aattggattc   1800

gccattttat ttttcttgct gctaaatcac cgagcccgga agattagaga gttttatttc   1860

tgggattcct gtagacacac ccacccacat acatacattt atatatatat atattatata   1920

tatataaaaa taaatatctc tattttatat atataaaata tatatattct ttttttaaat   1980

taacagtgct aatgttattg gtgtcttcac tggatgtatt tgactgctgt ggacttgagt   2040

tgggagggga atgttcccac tcagatcctg acagggaaga ggaggagatg agagactctg   2100

gcatgatctt ttttttgtcc cacttggtgg ggccagggtc ctctcccctg cccaggaatg   2160

tgcaaggcca gggcatgggg gcaaatatga cccagttttg ggaacaccga caaacccagc   2220

cctggcgctg agcctctcta ccccaggtca gacggacaga aagacagatc acaggtacag   2280

ggatgaggac accggctctg accaggagtt tggggagctt caggacattg ctgtgctttg   2340

gggattccct ccacatgctg cacgcgcatc tcgcccccag gggcactgcc tggaagattc   2400

aggagcctgg gcggccttcg cttactctca cctgcttctg agttgcccag gagaccactg   2460

gcagatgtcc cggcgaagag aagagacaca ttgttggaag aagcagccca tgacagctcc   2520

ccttcctggg actcgccctc atcctcttcc tgctcccctt cctggggtgc agcctaaaag   2580

gacctatgtc ctcacaccat tgaaaccact agttctgtcc ccccaggaga cctggttgtg   2640

tgtgtgtgag tggttgacct tcctccatcc cctggtcctt cccttccctt cccgaggcac   2700

agagagacag ggcaggatcc acgtgcccat tgtggaggca gagaaaagag aaagtgtttt   2760

atatacggta cttatttaat atcccttttt aattagaaat taaaacagtt aatttaatta   2820

aagagtaggg ttttttttca gtattcttgg ttaatattta atttcaacta tttatgagat   2880

gtatcttttg ctctctcttg ctctcttatt tgtaccggtt tttgtatata aaattcatgt   2940

ttccaatctc tctctccctg atcggtgaca gtcactagct tatcttgaac agatatttaa   3000

ttttgctaac actcagctct gccctccccg atcccctggc tccccagcac acattccttt   3060

gaaataaggt ttcaatatac atctacatac tatatatata tttggcaact tgtatttgtg   3120

tgtatatata tatatatatg tttatgtata tatgtgattc tgataaaata gacattgcta   3180

ttctgttttt tatatgtaaa aacaaaacaa gaaaaaatag agaattctac atactaaatc   3240

tctctccttt tttaatttta atatttgtta tcatttattt attggtgcta ctgtttatcc   3300

gtaataattg tggggaaaag atattaacat cacgtctttg tctctagtgc agtttttcga   3360

gatattccgt agtacatatt tatttttaaa caacgacaaa gaaatacaga tatatcttaa   3420

aaaaaaaaaa gcattttgta ttaaagaatt taattctgat ctcaaaaaaa aaaaaa       3476


<210>  1802
<211>  371
<212>  PRT
<213>  Homosapiens

<400>  1802

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 
                325                 330                 335     


Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 
            340                 345                 350         


Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Ser Leu Thr 
        355                 360                 365             


Arg Lys Asp 
    370     


<210>  1803
<211>  3614
<212>  DNA
<213>  Homosapiens

<400>  1803
ggcttggggc agccgggtag ctcggaggtc gtggcgctgg gggctagcac cagcgctctg     60

tcgggaggcg cagcggttag gtggaccggt cagcggactc accggccagg gcgctcggtg    120

ctggaatttg atattcattg atccgggttt tatccctctt cttttttctt aaacattttt    180

ttttaaaact gtattgtttc tcgttttaat ttatttttgc ttgccattcc ccacttgaat    240

cgggccgacg gcttggggag attgctctac ttccccaaat cactgtggat tttggaaacc    300

agcagaaaga ggaaagaggt agcaagagct ccagagagaa gtcgaggaag agagagacgg    360

ggtcagagag agcgcgcggg cgtgcgagca gcgaaagcga caggggcaaa gtgagtgacc    420

tgcttttggg ggtgaccgcc ggagcgcggc gtgagccctc ccccttggga tcccgcagct    480

gaccagtcgc gctgacggac agacagacag acaccgcccc cagccccagc taccacctcc    540

tccccggccg gcggcggaca gtggacgcgg cggcgagccg cgggcagggg ccggagcccg    600

cgcccggagg cggggtggag ggggtcgggg ctcgcggcgt cgcactgaaa cttttcgtcc    660

aacttctggg ctgttctcgc ttcggaggag ccgtggtccg cgcgggggaa gccgagccga    720

gcggagccgc gagaagtgct agctcgggcc gggaggagcc gcagccggag gagggggagg    780

aggaagaaga gaaggaagag gagagggggc cgcagtggcg actcggcgct cggaagccgg    840

gctcatggac gggtgaggcg gcggtgtgcg cagacagtgc tccagccgcg cgcgctcccc    900

aggccctggc ccgggcctcg ggccggggag gaagagtagc tcgccgaggc gccgaggaga    960

gcgggccgcc ccacagcccg agccggagag ggagcgcgag ccgcgccggc cccggtcggg   1020

cctccgaaac catgaacttt ctgctgtctt gggtgcattg gagccttgcc ttgctgctct   1080

acctccacca tgccaagtgg tcccaggctg cacccatggc agaaggagga gggcagaatc   1140

atcacgaagt ggtgaagttc atggatgtct atcagcgcag ctactgccat ccaatcgaga   1200

ccctggtgga catcttccag gagtaccctg atgagatcga gtacatcttc aagccatcct   1260

gtgtgcccct gatgcgatgc gggggctgct gcaatgacga gggcctggag tgtgtgccca   1320

ctgaggagtc caacatcacc atgcagatta tgcggatcaa acctcaccaa ggccagcaca   1380

taggagagat gagcttccta cagcacaaca aatgtgaatg cagaccaaag aaagatagag   1440

caagacaaga aaaaaaatca gttcgaggaa agggaaaggg gcaaaaacga aagcgcaaga   1500

aatcccggta taagtcctgg agcgttccct gtgggccttg ctcagagcgg agaaagcatt   1560

tgtttgtaca agatccgcag acgtgtaaat gttcctgcaa aaacacagac tcgcgttgca   1620

aggcgaggca gcttgagtta aacgaacgta cttgcagatg tgacaagccg aggcggtgag   1680

ccgggcagga ggaaggagcc tccctcaggg tttcgggaac cagatctctc accaggaaag   1740

actgatacag aacgatcgat acagaaacca cgctgccgcc accacaccat caccatcgac   1800

agaacagtcc ttaatccaga aacctgaaat gaaggaagag gagactctgc gcagagcact   1860

ttgggtccgg agggcgagac tccggcggaa gcattcccgg gcgggtgacc cagcacggtc   1920

cctcttggaa ttggattcgc cattttattt ttcttgctgc taaatcaccg agcccggaag   1980

attagagagt tttatttctg ggattcctgt agacacaccc acccacatac atacatttat   2040

atatatatat attatatata tataaaaata aatatctcta ttttatatat ataaaatata   2100

tatattcttt ttttaaatta acagtgctaa tgttattggt gtcttcactg gatgtatttg   2160

actgctgtgg acttgagttg ggaggggaat gttcccactc agatcctgac agggaagagg   2220

aggagatgag agactctggc atgatctttt ttttgtccca cttggtgggg ccagggtcct   2280

ctcccctgcc caggaatgtg caaggccagg gcatgggggc aaatatgacc cagttttggg   2340

aacaccgaca aacccagccc tggcgctgag cctctctacc ccaggtcaga cggacagaaa   2400

gacagatcac aggtacaggg atgaggacac cggctctgac caggagtttg gggagcttca   2460

ggacattgct gtgctttggg gattccctcc acatgctgca cgcgcatctc gcccccaggg   2520

gcactgcctg gaagattcag gagcctgggc ggccttcgct tactctcacc tgcttctgag   2580

ttgcccagga gaccactggc agatgtcccg gcgaagagaa gagacacatt gttggaagaa   2640

gcagcccatg acagctcccc ttcctgggac tcgccctcat cctcttcctg ctccccttcc   2700

tggggtgcag cctaaaagga cctatgtcct cacaccattg aaaccactag ttctgtcccc   2760

ccaggagacc tggttgtgtg tgtgtgagtg gttgaccttc ctccatcccc tggtccttcc   2820

cttcccttcc cgaggcacag agagacaggg caggatccac gtgcccattg tggaggcaga   2880

gaaaagagaa agtgttttat atacggtact tatttaatat ccctttttaa ttagaaatta   2940

aaacagttaa tttaattaaa gagtagggtt ttttttcagt attcttggtt aatatttaat   3000

ttcaactatt tatgagatgt atcttttgct ctctcttgct ctcttatttg taccggtttt   3060

tgtatataaa attcatgttt ccaatctctc tctccctgat cggtgacagt cactagctta   3120

tcttgaacag atatttaatt ttgctaacac tcagctctgc cctccccgat cccctggctc   3180

cccagcacac attcctttga aataaggttt caatatacat ctacatacta tatatatatt   3240

tggcaacttg tatttgtgtg tatatatata tatatatgtt tatgtatata tgtgattctg   3300

ataaaataga cattgctatt ctgtttttta tatgtaaaaa caaaacaaga aaaaatagag   3360

aattctacat actaaatctc tctccttttt taattttaat atttgttatc atttatttat   3420

tggtgctact gtttatccgt aataattgtg gggaaaagat attaacatca cgtctttgtc   3480

tctagtgcag tttttcgaga tattccgtag tacatattta tttttaaaca acgacaaaga   3540

aatacagata tatcttaaaa aaaaaaaagc attttgtatt aaagaattta attctgatct   3600

caaaaaaaaa aaaa                                                     3614


<210>  1804
<211>  395
<212>  PRT
<213>  Homosapiens

<400>  1804

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Pro Cys Gly Pro Cys Ser Glu 
            340                 345                 350         


Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser 
        355                 360                 365             


Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn 
    370                 375                 380                 


Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
385                 390                 395 


<210>  1805
<211>  3180
<212>  DNA
<213>  Homosapiens

<400>  1805
ggaagctccg cgcggcggcg ggggcggcga cggcgactgg cgggtgggag tggaggcacc     60

ggctggcggg cgggggtaca gggacggggc aggggctccc gctccaggtt ccttgaagca    120

cttccgaccg cgaagcccgg cgcgagaagc gagctaaccc aagagccaac aacgagcgcg    180

gagagggcag cggactgagc ggagccgccg gccagagcgg gctcggagcc cgggtctccg    240

ccgctcggga cccggctagg cggcggcggg ggcggcgatg ttccactgca tccccctgtg    300

gcggtgcaac cgtcatgtgg agagcatcga caagcgccac tgctcgctgg tctacgtccc    360

cgaggagatc taccgctatg cccggagcct ggaggagctg ctgctggacg ccaaccagct    420

ccgcgagctg cccgagcaat ttttccagct agtcaaatta cgaaagcttg gacttagtga    480

taatgaaatt cagcggctcc ctccagaaat agcaaacttc atgcagctgg tggaactaga    540

tgtgtctcga aatgagattc ctgaaattcc agaaagcatt tcattctgta aagcactgca    600

ggtagctgac ttcagcggaa acccactgac taggttgcca gaaagctttc ctgaattaca    660

gaatttaaca tgtctttctg taaatgacat ctcactacag tctctacctg aaaatattgg    720

caatctttat aacctggctt cactggaact gagagagaat cttcttacat atcttcctga    780

ctctcttacc cagctgcgaa gactagaaga acttgattta ggaaacaatg aaatatataa    840

tttgccagaa tcaattggag ccctcttaca tctaaaagat ctctggttgg atggaaatca    900

actgtcagaa ttacctcagg aaataggaaa tctgaagaac ctgctgtgtt tagatgtctc    960

tgaaaacagg ttggaaagac ttcctgaaga aatcagtggc ctgacttcat taacggattt   1020

agtcatttcc cagaacttat tagaaacgat tccggatggc attggaaaac taaagaaact   1080

gtcaatcttg aaggtggatc agaatagact cacacagttg cctgaagcag ttggggaatg   1140

tgaaagtctc actgagttag ttcttacaga aaatcagctc ctgaccctgc ctaaaagcat   1200

tggaaaacta aagaagttga gcaacttgaa tgcagacaga aataaattag tgtccttacc   1260

aaaagagatc ggcgggtgct gcagcctcac tgtgttctgt gtacgtgaca acagactaac   1320

tcggatacct gcagaggtgt cacaggcaac agaacttcat gtcctggatg tggcagggaa   1380

caggttgctg catctacctt tatccctgac tgccttgaag ttgaaggctc tgtggctatc   1440

tgacaaccag tcccagcccc tgcttacatt ccagacagac acagactaca ccacaggaga   1500

gaagatttta acctgtgtct tacttcctca gctgccttct gaacctactt gtcaagagaa   1560

tctgcctcgc tgtggtgcac tggagaactt ggtaaatgat gtctctgatg aagcctggaa   1620

cgagcgtgct gtcaacagag tcagtgcgat ccgatttgtg gaggatgaga aagatgaaga   1680

agacaatgag acgagaacac ttctaaggcg agccactcca cacccagggg agttaaagca   1740

catgaaaaag acagtggaga atttacggaa tgacatgaat gctgctaaag gactggactc   1800

aaacaaaaac gaggtcaatc atgccattga ccgagtgacc acttctgtgt agagtttcac   1860

ctccaagttt tacctcctgt gtcttcctct gctgtcgaga cgttcctgtc tgcttcccgg   1920

gagcctcacg tgctccttgt cctaaccagc ccccgcgcgc catcttcccg tggagtgtgg   1980

ggaagctgct gtctcccagg aagtgcctta ctcatcccgc aaccagtcag cgcaccagtg   2040

gtctcccggt gtgatttttt ttttttttaa tttcagttgt ttgtaataag tagaatacac   2100

tactgtaaac atacgacctt tgtttttgtc ttatgttggg gtaaaggaaa gcaggaaggg   2160

gaatttttat cctcctccct tccgtaaagt gctgggatat tttgaatccc ccaagttccc   2220

ttggacctac tgatgagaga tagttttatg tatggggaaa aatggatact ttttaaacct   2280

tttttggcag ctcagatggt gtaaatttta aaattttgta taggtatttc ataacaaaaa   2340

tatgtatttc ttttttgtta ttttatcttg aaaacggtac atattttagt atttgtgcag   2400

aaaaacaagt cctaaagtat ttgtttttat ttgtaccatc cacttgtgcc ttactgtatc   2460

ctgtgtcatg tccaatcagt tgtaaacaat ggcatctttg aacagtgtga tgagaatagg   2520

aatgtggtgt tttaaagcag tgttgcattt taatcagtaa tctacctggt ggatttgttt   2580

ttaaccaaaa agatgaatta tcaatgattt gtaattatat cagttgattt tttttgaaaa   2640

gatgaaccaa aggatttgac tgctaatatt ttattcctta cacttttttt ctgaataagt   2700

ctctcataat gagtgcagtg tcagactgtg cctactctga tggtatgtgc catttgtaaa   2760

ataaaataga gcagaaaaac acaaaaagag aacactggtt cagacattca gtgggcaagt   2820

aaattatgga ctgcaaaata atgattttta ttcaagaaag ctttaaaagt tttatatcca   2880

gatatacaac cacaataaag caaaataacc tactatcaaa atagaaatgt tgctatcttt   2940

ataagtgcaa tttaatttgt aaatagagtt tgaatcaaag tatcacaaaa tactgcttca   3000

agatttaatt ttaaatctgc taatttaagg gatattggga aaagttttgg tgtgtttctg   3060

ttgatttctt ttttgtatgc tgtgataaaa gagaaatgaa aagtgccagt cactgtgtgg   3120

tgtctaggaa aatcatatat atttttttct ccaagaaata aattcatcct ggacattggc   3180


<210>  1806
<211>  524
<212>  PRT
<213>  Homosapiens

<400>  1806

Met Phe His Cys Ile Pro Leu Trp Arg Cys Asn Arg His Val Glu Ser 
1               5                   10                  15      


Ile Asp Lys Arg His Cys Ser Leu Val Tyr Val Pro Glu Glu Ile Tyr 
            20                  25                  30          


Arg Tyr Ala Arg Ser Leu Glu Glu Leu Leu Leu Asp Ala Asn Gln Leu 
        35                  40                  45              


Arg Glu Leu Pro Glu Gln Phe Phe Gln Leu Val Lys Leu Arg Lys Leu 
    50                  55                  60                  


Gly Leu Ser Asp Asn Glu Ile Gln Arg Leu Pro Pro Glu Ile Ala Asn 
65                  70                  75                  80  


Phe Met Gln Leu Val Glu Leu Asp Val Ser Arg Asn Glu Ile Pro Glu 
                85                  90                  95      


Ile Pro Glu Ser Ile Ser Phe Cys Lys Ala Leu Gln Val Ala Asp Phe 
            100                 105                 110         


Ser Gly Asn Pro Leu Thr Arg Leu Pro Glu Ser Phe Pro Glu Leu Gln 
        115                 120                 125             


Asn Leu Thr Cys Leu Ser Val Asn Asp Ile Ser Leu Gln Ser Leu Pro 
    130                 135                 140                 


Glu Asn Ile Gly Asn Leu Tyr Asn Leu Ala Ser Leu Glu Leu Arg Glu 
145                 150                 155                 160 


Asn Leu Leu Thr Tyr Leu Pro Asp Ser Leu Thr Gln Leu Arg Arg Leu 
                165                 170                 175     


Glu Glu Leu Asp Leu Gly Asn Asn Glu Ile Tyr Asn Leu Pro Glu Ser 
            180                 185                 190         


Ile Gly Ala Leu Leu His Leu Lys Asp Leu Trp Leu Asp Gly Asn Gln 
        195                 200                 205             


Leu Ser Glu Leu Pro Gln Glu Ile Gly Asn Leu Lys Asn Leu Leu Cys 
    210                 215                 220                 


Leu Asp Val Ser Glu Asn Arg Leu Glu Arg Leu Pro Glu Glu Ile Ser 
225                 230                 235                 240 


Gly Leu Thr Ser Leu Thr Asp Leu Val Ile Ser Gln Asn Leu Leu Glu 
                245                 250                 255     


Thr Ile Pro Asp Gly Ile Gly Lys Leu Lys Lys Leu Ser Ile Leu Lys 
            260                 265                 270         


Val Asp Gln Asn Arg Leu Thr Gln Leu Pro Glu Ala Val Gly Glu Cys 
        275                 280                 285             


Glu Ser Leu Thr Glu Leu Val Leu Thr Glu Asn Gln Leu Leu Thr Leu 
    290                 295                 300                 


Pro Lys Ser Ile Gly Lys Leu Lys Lys Leu Ser Asn Leu Asn Ala Asp 
305                 310                 315                 320 


Arg Asn Lys Leu Val Ser Leu Pro Lys Glu Ile Gly Gly Cys Cys Ser 
                325                 330                 335     


Leu Thr Val Phe Cys Val Arg Asp Asn Arg Leu Thr Arg Ile Pro Ala 
            340                 345                 350         


Glu Val Ser Gln Ala Thr Glu Leu His Val Leu Asp Val Ala Gly Asn 
        355                 360                 365             


Arg Leu Leu His Leu Pro Leu Ser Leu Thr Ala Leu Lys Leu Lys Ala 
    370                 375                 380                 


Leu Trp Leu Ser Asp Asn Gln Ser Gln Pro Leu Leu Thr Phe Gln Thr 
385                 390                 395                 400 


Asp Thr Asp Tyr Thr Thr Gly Glu Lys Ile Leu Thr Cys Val Leu Leu 
                405                 410                 415     


Pro Gln Leu Pro Ser Glu Pro Thr Cys Gln Glu Asn Leu Pro Arg Cys 
            420                 425                 430         


Gly Ala Leu Glu Asn Leu Val Asn Asp Val Ser Asp Glu Ala Trp Asn 
        435                 440                 445             


Glu Arg Ala Val Asn Arg Val Ser Ala Ile Arg Phe Val Glu Asp Glu 
    450                 455                 460                 


Lys Asp Glu Glu Asp Asn Glu Thr Arg Thr Leu Leu Arg Arg Ala Thr 
465                 470                 475                 480 


Pro His Pro Gly Glu Leu Lys His Met Lys Lys Thr Val Glu Asn Leu 
                485                 490                 495     


Arg Asn Asp Met Asn Ala Ala Lys Gly Leu Asp Ser Asn Lys Asn Glu 
            500                 505                 510         


Val Asn His Ala Ile Asp Arg Val Thr Thr Ser Val 
        515                 520                 


<210>  1807
<211>  1740
<212>  DNA
<213>  Homosapiens

<400>  1807
gtctctcagt ctttctctct ttctcattct ctttcaatat ggaacttgaa aagcgtgaaa     60

aaagaagctt attaaacaag aatttagagg agaaactgac ggtctctgct ggtggttctg    120

aagccaaacc tctgatcttc acatttgtcc ccactgtcag aagactacca acccatactc    180

agttggctga cacctctaaa ttccttgtta aaattccaga agaatcaagt gataagagtc    240

cagaaactgt aaataggtct aaatccaatg actacttgac cttgaatgct gggagccaac    300

aagagagaga ccaagcgaaa ttgacttgtc cttcagaggt cagtggaacg attttacaag    360

aaagggaatt cgaagcaaac aaacttcaag ggatgcagca aagtgacctc ttcaaagctg    420

aatatgtcct tattgtggac tccgaagggg aagatgaggc tgcaagcaga aaagttgaac    480

aaggcccccc aggggggatt ggcaccgcag ctatccggcc caagtctcta gctatctcgt    540

ccagtctggt ctctgatgta gtgcgtccca aaacacaggg gactgatctc aagacctcat    600

cacatcctga aatgcttcat gggatggccc ctcagcaaaa gcatgggcag caatacaaga    660

ccaagtcaag ctacaaggct tttgcagcaa tccctacaaa cacattgctt ttggaacaga    720

aggcactaga tgaaccagcc aagactgaaa gtgtctccaa ggacaacaca ttagaaccac    780

cagtggagct ctattttcct gcacagctca ggcagcaaac tgaagagctc tgtgctacca    840

ttgataaggt cttacaggat tccttgtcta tgcattcttc tgattctcct tcaaggtccc    900

caaagacatt gttgggttct gacacagtca aaactcctac aactcttcca agagcagctg    960

gtcgagaaac caaatatgca aatctctcct caccaacttc tacagtatct gagagtcagc   1020

tgactaagcc tggagtaatt cgcccagtac ctgtaaaatc cagaatatta ctgaaaaaag   1080

aggaggaagt ctatgaaccc aaccctttca gtaaatactt ggaagataac agcgacctct   1140

tttctgaaca ggatgtaaca gtccctccca agcctgtctc gctccatcct ttatatcaga   1200

ctaaactcta tcctcctgct aagtcactgc tgcatccaca gaccctctca catgctgact   1260

gtcttgcccc aggacccttc agtcatctgt ccttctcctt gagtgatgaa caggagaatt   1320

ctcacaccct cctcagtcac aacgcatgca acaagctgag tcatccaatg gtggctattc   1380

ctgaacatga agctcttgat tccaaagagc aatgaagttg gagcagaggc tgaaaacaca   1440

ggctgctgaa gtttttttgg aatgctggtg ctaaccactt gctagattta actttttttt   1500

tttttttcca gaatgagtgc tccctttatg agctgcagtg cagcagaacc aaaaaaaaag   1560

tttgctgcaa ttatatagca tcacagtgct ctgctaacag ccagcataga agagatttac   1620

ctacagcttt ttgcaccact gttctagcct ttaatgcctt ctacttaata ttaagctgac   1680

cgcaatacta acgtgcccct atatttggca gccaaataaa gaagaatcgt gggtaaatag   1740


<210>  1808
<211>  458
<212>  PRT
<213>  Homosapiens

<400>  1808

Met Glu Leu Glu Lys Arg Glu Lys Arg Ser Leu Leu Asn Lys Asn Leu 
1               5                   10                  15      


Glu Glu Lys Leu Thr Val Ser Ala Gly Gly Ser Glu Ala Lys Pro Leu 
            20                  25                  30          


Ile Phe Thr Phe Val Pro Thr Val Arg Arg Leu Pro Thr His Thr Gln 
        35                  40                  45              


Leu Ala Asp Thr Ser Lys Phe Leu Val Lys Ile Pro Glu Glu Ser Ser 
    50                  55                  60                  


Asp Lys Ser Pro Glu Thr Val Asn Arg Ser Lys Ser Asn Asp Tyr Leu 
65                  70                  75                  80  


Thr Leu Asn Ala Gly Ser Gln Gln Glu Arg Asp Gln Ala Lys Leu Thr 
                85                  90                  95      


Cys Pro Ser Glu Val Ser Gly Thr Ile Leu Gln Glu Arg Glu Phe Glu 
            100                 105                 110         


Ala Asn Lys Leu Gln Gly Met Gln Gln Ser Asp Leu Phe Lys Ala Glu 
        115                 120                 125             


Tyr Val Leu Ile Val Asp Ser Glu Gly Glu Asp Glu Ala Ala Ser Arg 
    130                 135                 140                 


Lys Val Glu Gln Gly Pro Pro Gly Gly Ile Gly Thr Ala Ala Ile Arg 
145                 150                 155                 160 


Pro Lys Ser Leu Ala Ile Ser Ser Ser Leu Val Ser Asp Val Val Arg 
                165                 170                 175     


Pro Lys Thr Gln Gly Thr Asp Leu Lys Thr Ser Ser His Pro Glu Met 
            180                 185                 190         


Leu His Gly Met Ala Pro Gln Gln Lys His Gly Gln Gln Tyr Lys Thr 
        195                 200                 205             


Lys Ser Ser Tyr Lys Ala Phe Ala Ala Ile Pro Thr Asn Thr Leu Leu 
    210                 215                 220                 


Leu Glu Gln Lys Ala Leu Asp Glu Pro Ala Lys Thr Glu Ser Val Ser 
225                 230                 235                 240 


Lys Asp Asn Thr Leu Glu Pro Pro Val Glu Leu Tyr Phe Pro Ala Gln 
                245                 250                 255     


Leu Arg Gln Gln Thr Glu Glu Leu Cys Ala Thr Ile Asp Lys Val Leu 
            260                 265                 270         


Gln Asp Ser Leu Ser Met His Ser Ser Asp Ser Pro Ser Arg Ser Pro 
        275                 280                 285             


Lys Thr Leu Leu Gly Ser Asp Thr Val Lys Thr Pro Thr Thr Leu Pro 
    290                 295                 300                 


Arg Ala Ala Gly Arg Glu Thr Lys Tyr Ala Asn Leu Ser Ser Pro Thr 
305                 310                 315                 320 


Ser Thr Val Ser Glu Ser Gln Leu Thr Lys Pro Gly Val Ile Arg Pro 
                325                 330                 335     


Val Pro Val Lys Ser Arg Ile Leu Leu Lys Lys Glu Glu Glu Val Tyr 
            340                 345                 350         


Glu Pro Asn Pro Phe Ser Lys Tyr Leu Glu Asp Asn Ser Asp Leu Phe 
        355                 360                 365             


Ser Glu Gln Asp Val Thr Val Pro Pro Lys Pro Val Ser Leu His Pro 
    370                 375                 380                 


Leu Tyr Gln Thr Lys Leu Tyr Pro Pro Ala Lys Ser Leu Leu His Pro 
385                 390                 395                 400 


Gln Thr Leu Ser His Ala Asp Cys Leu Ala Pro Gly Pro Phe Ser His 
                405                 410                 415     


Leu Ser Phe Ser Leu Ser Asp Glu Gln Glu Asn Ser His Thr Leu Leu 
            420                 425                 430         


Ser His Asn Ala Cys Asn Lys Leu Ser His Pro Met Val Ala Ile Pro 
        435                 440                 445             


Glu His Glu Ala Leu Asp Ser Lys Glu Gln 
    450                 455             


<210>  1809
<211>  5241
<212>  DNA
<213>  Homosapiens

<400>  1809
ggaagcccgg gagtgagaga aagcggctcc gggggcatag cgggccagta agggccgctc     60

ctcctttgaa gaggttttgc gtctctttcc gccggtggcg tcggcgctca cgcaggggcg    120

ggtcccggta gcgccaggcg gtgcagggcg ggaaggggat tcgtggcgac ggcggcggca    180

gggacagcag gagcagtggt gctgtcagcg cggccgtcgg agacatggga gacccggggt    240

cggagataat agaatctgtc cctccagctg gccctgaggc atctgagtca acaacggatg    300

aaaatgaaga cgacattcag tttgtcagtg aaggaccatt acgacctgtt cttgaataca    360

ttgatctggt cagcagtgat gatgaagagc ctagcacctc ttatactgat gagaatatta    420

aacgtaaaga ccatattgat tatcagaagg ataaagttgc tttaactctg gctcgtctag    480

cccgccatgt tgaagtggag aaacagcaga aagaagagaa gaatagagca ttcagagaaa    540

aaattgattt tcagcatgct catgggttac aagaattgga atttattcga ggacattctg    600

atacagaagc agcaagactg tgtgtggacc agtggctaaa aatgccagga ctcaaaacag    660

gcacaattaa ttgtggaaca aaaagttcat tccgaagagg aggccacacg tgggtgtctg    720

ggaaaccaat tttatgtcct ataatgcact gtaacaagga gtttgacaat gggcaccttc    780

tcttaggaca tttgaaaagg ttcgatcact ctccatgtga tccaacaatt acactacatg    840

gacctttctt cagctccttt gcttgtgtag tatgttataa aaaatttgtt actcaacaac    900

aatatagaga tcaccttttt gataaggaag ccacagatga tggacataac aacaaccttc    960

ttcctcagat tattcagtgt tttgcatgtc caaattgctt ccttcttttt agcagaaagg   1020

aggagtgttc aaagcatatg tctggaaaga atcatttcca tcagagtttc aaactgggtg   1080

ataacaaagg aattgcacat ccaatatctt tcccatcttt tgcaaagaaa cttttgatct   1140

ctctgtgcaa agatgttccc tttcaagtta agtgtgtggc ctgccacaag acactgcgtt   1200

cccacatgga gctcactgcc catttcagag ttcattgtcg aaatgctgga cctgtagctg   1260

tagctgagaa gagcattacc caggttgcag agaaattcat attaagaggt tattgtccag   1320

attgcaatca agtctttgtg gatgaaacca gcacccaaaa tcataagcag aattcaggac   1380

acaaagtccg agtcattaac tcagtggaag aatcagtctt actctattgc cacagcagcg   1440

aagggaacaa ggatccttct tctgacttgc atttattgtt ggatcaatca aaattttcat   1500

cacttaaaag aaccatgtct attaaagaat ctagctcact ggagtgcatt gccattccaa   1560

aaaagaagat gaatttaaaa gataaaagcc atgaaggtgt tgcttgtgtc cagaaagaaa   1620

aatcagtagt taaaacctgg ttctgtgaat gcaatcagcg attcccaagt gaagatgcag   1680

tagaaaagca tgttttctca gcaaacacaa tgggttataa atgtgtggtc tgtggaaagg   1740

tatgtgatga ttcaggggtc attcgtttac acatgagccg gattcacgga ggggcacatt   1800

taaataactt tcttttctgg tgtcggacat gcaaaaagga gttaacaagg aaagatacta   1860

tcatggcaca tgtgactgaa tttcataatg gacacagata tttttatgag atggatgagg   1920

tagaaggtga aactttgcca tcatcctcta caacattgga taatttgact gctaacaagc   1980

cttcatcagc tattactgtt attgatcatt ccccggcaaa tagttctccg aggggtaaat   2040

ggcaatgccg gatttgtgaa gatatgtttg attcccagga atatgtaaaa cagcactgca   2100

tgtctttggc aagccacaag tttcatagat acagctgtgc tcactgcaga aagccttttc   2160

ataagataga aacattgtac cgacattgcc aagatgagca tgacaatgag ataaagatta   2220

aatacttctg tgggctttgt gatcttatct ttaatgtgga agaagcattt ctgagtcatt   2280

atgaggagca ccacagcata gattatgtat ttgtgtcaga aaaaactgaa acttcaatta   2340

aaaccgaaga tgattttcca gtaatagaga ccagtaacca gttaacttgt ggttgccgtg   2400

agagttacat ctgtaaagtc aacagaaaag aagattatag cagatgtctc caaatcatgc   2460

tggataaagg aaaactgtgg tttcgctgca gtttatgttc ggcaacagca cagaatttaa   2520

ccgacatgaa cactcatatc catcaagtgc acaaagaaaa gagtgatgag gaggagcagc   2580

agtatgtaat caagtgtggc acctgcacca aagcatttca tgatcctgag agtgcacagc   2640

agcatttcca tagaaaacat tgcttcttac agaaacccag tgtggctcat tttggatctg   2700

aaaaatcaaa cctgtacaag tttactgcta gtgcctcaca tacagagaga aaactgaaac   2760

aggcaataaa ctattcaaaa agtttagaca tggagaaagg agttgagaat gacctaagct   2820

atcagaatat agaggaagaa attgttgagc ttccagattt ggattacctg cgaaccatga   2880

ctcatatagt ctttgtagat tttgataact ggtcaaactt ttttggtcat ctaccagggc   2940

atctaaacca aggaacattt atttggggct ttcaaggagg aaacaccaat tggaagcctc   3000

cgctcaactg taagatttat aactacctga acaggattgg atgcttcttc cttcatcctc   3060

gctgtagtaa aagaaaagat gctgctgatt ttgccatatg tatgcatgct ggccgtctag   3120

atgaacaact acccaagcaa attcctttca ccatcctctc aggagatcaa ggttttctgg   3180

agctagagaa tcaatttaag aagactcaga ggccagctca tatactaaac cctcaccact   3240

tagagggaga tatgatgtgt gccttgttaa atagcatatc tgataccacc aaagaatgtg   3300

acagtgatga taacatgggt gccaaaaata cttcaatagg agaagaattt atatccacag   3360

aagatgtgga attagaagaa gctattagaa gaagtcttga ggaaatgtaa ttaaagatat   3420

taccacacaa catcaagtgg ccttgaagag actgagataa cgaattcttg agtttgtttt   3480

ctaaaggaga ccagaaatcc actattacaa atgtatttga aaacatgttt ttgctttcat   3540

atgttcaaaa tctgatcttt gttttgtatt tttgtgctaa tgtgcaaaca tgtacagaag   3600

aaatagaata catgttcatg caaatataaa ttatgtattc taatataggt gtaacagttt   3660

cccagttaac tttgaattta tatatttaga tttaaaggat taaaaaaaag gaaagctctt   3720

gacagttgtt tcccaaatag cattagttct ttaattttat ttgtactgta caaatgatgc   3780

tagtttattt ttttagcagt gaaaatgaat ataaaaaagg tgacataggt caagttttcc   3840

ataaattcta cttctcatgt ggcactatta tataatacct ttgagatctt tgtttatgtt   3900

tattagaaga gggtaatgga aactgatcat ggaaacattt aaaattttat cagcaatgtt   3960

ctttgtgggt gccatgcata tgtaaattat tgctttaatt agagcagcac attgctaaaa   4020

taaaaaatac accttaattt ttaagaaata atttaaatga aacaatttcc attcctttta   4080

cctgcttaga cttttatgtg acttgtatgg tctcctggtt aaagggaatg gtgtcagaat   4140

atttgcataa aattattttt cataacagtc cttttttata tattggtgta aacataatat   4200

tcttcaagaa ataatgttga aagcctactc aggaataatc ttccttaact ctttaaattt   4260

ttatttcatg tgaagtgttt tcagtttagt tattcactga attgtcagtt tccttcattt   4320

ggtattacat atttaattct taaatattga ggccccattg tgagtaataa aaaatacgac   4380

ataagtagaa gactaagaag ggcttgtcat attatctttg tgtatatgct tcatgttatt   4440

taaccagaaa tgtcttatct ctaaaaattt ttagtagtaa ttatttacca aacttaaaaa   4500

catttctata aatataaagc ttttctttat atttaagaca aaatataaag gctagaattt   4560

ggttccttct ctgtaacact aaatatttta gtgtgaaatt gaattttttt attactatag   4620

tcttttcaat ctataatttg tgtttttaat ttcttgatat gtcacttctg ttcctccctg   4680

cttgcatttt ttaaaaacta gacattgtgg cttgagaatt tatcaatcat ctttccgaaa   4740

tgaccacatt gtgcttttag tttgtatgtt taagtggtca agcaaggctc taggaggtag   4800

tcactgagct ggaccttaaa cacatctgca ggagctcaca aaatgggagc aaaagaggca   4860

ttccagaaag aagagtagtt aagcagatgt gggggcaggg caagaggaga cagcaccttg   4920

ttgccagaga ttctacacaa aggtgtgatg gacactgatg ctctattaag aagcttttgt   4980

ggtgtgtgtg gtagagaata attaaggctt ctgataagac aggaaaggga tatttcatca   5040

tgactgttaa gaaaaggtaa ctgggttgtt taatgtttta attgataatt gtcactgatc   5100

gtatttctac ttgttaaata attaaaaatc atcttaaaat tcatactttg actttaattt   5160

agacacaagg agatgtaatc gctgtgtaac atcagagaaa gctatatgga ttatcgtcag   5220

aagtaaatgt ttctaacatt g                                             5241


<210>  1810
<211>  1061
<212>  PRT
<213>  Homosapiens

<400>  1810

Met Gly Asp Pro Gly Ser Glu Ile Ile Glu Ser Val Pro Pro Ala Gly 
1               5                   10                  15      


Pro Glu Ala Ser Glu Ser Thr Thr Asp Glu Asn Glu Asp Asp Ile Gln 
            20                  25                  30          


Phe Val Ser Glu Gly Pro Leu Arg Pro Val Leu Glu Tyr Ile Asp Leu 
        35                  40                  45              


Val Ser Ser Asp Asp Glu Glu Pro Ser Thr Ser Tyr Thr Asp Glu Asn 
    50                  55                  60                  


Ile Lys Arg Lys Asp His Ile Asp Tyr Gln Lys Asp Lys Val Ala Leu 
65                  70                  75                  80  


Thr Leu Ala Arg Leu Ala Arg His Val Glu Val Glu Lys Gln Gln Lys 
                85                  90                  95      


Glu Glu Lys Asn Arg Ala Phe Arg Glu Lys Ile Asp Phe Gln His Ala 
            100                 105                 110         


His Gly Leu Gln Glu Leu Glu Phe Ile Arg Gly His Ser Asp Thr Glu 
        115                 120                 125             


Ala Ala Arg Leu Cys Val Asp Gln Trp Leu Lys Met Pro Gly Leu Lys 
    130                 135                 140                 


Thr Gly Thr Ile Asn Cys Gly Thr Lys Ser Ser Phe Arg Arg Gly Gly 
145                 150                 155                 160 


His Thr Trp Val Ser Gly Lys Pro Ile Leu Cys Pro Ile Met His Cys 
                165                 170                 175     


Asn Lys Glu Phe Asp Asn Gly His Leu Leu Leu Gly His Leu Lys Arg 
            180                 185                 190         


Phe Asp His Ser Pro Cys Asp Pro Thr Ile Thr Leu His Gly Pro Phe 
        195                 200                 205             


Phe Ser Ser Phe Ala Cys Val Val Cys Tyr Lys Lys Phe Val Thr Gln 
    210                 215                 220                 


Gln Gln Tyr Arg Asp His Leu Phe Asp Lys Glu Ala Thr Asp Asp Gly 
225                 230                 235                 240 


His Asn Asn Asn Leu Leu Pro Gln Ile Ile Gln Cys Phe Ala Cys Pro 
                245                 250                 255     


Asn Cys Phe Leu Leu Phe Ser Arg Lys Glu Glu Cys Ser Lys His Met 
            260                 265                 270         


Ser Gly Lys Asn His Phe His Gln Ser Phe Lys Leu Gly Asp Asn Lys 
        275                 280                 285             


Gly Ile Ala His Pro Ile Ser Phe Pro Ser Phe Ala Lys Lys Leu Leu 
    290                 295                 300                 


Ile Ser Leu Cys Lys Asp Val Pro Phe Gln Val Lys Cys Val Ala Cys 
305                 310                 315                 320 


His Lys Thr Leu Arg Ser His Met Glu Leu Thr Ala His Phe Arg Val 
                325                 330                 335     


His Cys Arg Asn Ala Gly Pro Val Ala Val Ala Glu Lys Ser Ile Thr 
            340                 345                 350         


Gln Val Ala Glu Lys Phe Ile Leu Arg Gly Tyr Cys Pro Asp Cys Asn 
        355                 360                 365             


Gln Val Phe Val Asp Glu Thr Ser Thr Gln Asn His Lys Gln Asn Ser 
    370                 375                 380                 


Gly His Lys Val Arg Val Ile Asn Ser Val Glu Glu Ser Val Leu Leu 
385                 390                 395                 400 


Tyr Cys His Ser Ser Glu Gly Asn Lys Asp Pro Ser Ser Asp Leu His 
                405                 410                 415     


Leu Leu Leu Asp Gln Ser Lys Phe Ser Ser Leu Lys Arg Thr Met Ser 
            420                 425                 430         


Ile Lys Glu Ser Ser Ser Leu Glu Cys Ile Ala Ile Pro Lys Lys Lys 
        435                 440                 445             


Met Asn Leu Lys Asp Lys Ser His Glu Gly Val Ala Cys Val Gln Lys 
    450                 455                 460                 


Glu Lys Ser Val Val Lys Thr Trp Phe Cys Glu Cys Asn Gln Arg Phe 
465                 470                 475                 480 


Pro Ser Glu Asp Ala Val Glu Lys His Val Phe Ser Ala Asn Thr Met 
                485                 490                 495     


Gly Tyr Lys Cys Val Val Cys Gly Lys Val Cys Asp Asp Ser Gly Val 
            500                 505                 510         


Ile Arg Leu His Met Ser Arg Ile His Gly Gly Ala His Leu Asn Asn 
        515                 520                 525             


Phe Leu Phe Trp Cys Arg Thr Cys Lys Lys Glu Leu Thr Arg Lys Asp 
    530                 535                 540                 


Thr Ile Met Ala His Val Thr Glu Phe His Asn Gly His Arg Tyr Phe 
545                 550                 555                 560 


Tyr Glu Met Asp Glu Val Glu Gly Glu Thr Leu Pro Ser Ser Ser Thr 
                565                 570                 575     


Thr Leu Asp Asn Leu Thr Ala Asn Lys Pro Ser Ser Ala Ile Thr Val 
            580                 585                 590         


Ile Asp His Ser Pro Ala Asn Ser Ser Pro Arg Gly Lys Trp Gln Cys 
        595                 600                 605             


Arg Ile Cys Glu Asp Met Phe Asp Ser Gln Glu Tyr Val Lys Gln His 
    610                 615                 620                 


Cys Met Ser Leu Ala Ser His Lys Phe His Arg Tyr Ser Cys Ala His 
625                 630                 635                 640 


Cys Arg Lys Pro Phe His Lys Ile Glu Thr Leu Tyr Arg His Cys Gln 
                645                 650                 655     


Asp Glu His Asp Asn Glu Ile Lys Ile Lys Tyr Phe Cys Gly Leu Cys 
            660                 665                 670         


Asp Leu Ile Phe Asn Val Glu Glu Ala Phe Leu Ser His Tyr Glu Glu 
        675                 680                 685             


His His Ser Ile Asp Tyr Val Phe Val Ser Glu Lys Thr Glu Thr Ser 
    690                 695                 700                 


Ile Lys Thr Glu Asp Asp Phe Pro Val Ile Glu Thr Ser Asn Gln Leu 
705                 710                 715                 720 


Thr Cys Gly Cys Arg Glu Ser Tyr Ile Cys Lys Val Asn Arg Lys Glu 
                725                 730                 735     


Asp Tyr Ser Arg Cys Leu Gln Ile Met Leu Asp Lys Gly Lys Leu Trp 
            740                 745                 750         


Phe Arg Cys Ser Leu Cys Ser Ala Thr Ala Gln Asn Leu Thr Asp Met 
        755                 760                 765             


Asn Thr His Ile His Gln Val His Lys Glu Lys Ser Asp Glu Glu Glu 
    770                 775                 780                 


Gln Gln Tyr Val Ile Lys Cys Gly Thr Cys Thr Lys Ala Phe His Asp 
785                 790                 795                 800 


Pro Glu Ser Ala Gln Gln His Phe His Arg Lys His Cys Phe Leu Gln 
                805                 810                 815     


Lys Pro Ser Val Ala His Phe Gly Ser Glu Lys Ser Asn Leu Tyr Lys 
            820                 825                 830         


Phe Thr Ala Ser Ala Ser His Thr Glu Arg Lys Leu Lys Gln Ala Ile 
        835                 840                 845             


Asn Tyr Ser Lys Ser Leu Asp Met Glu Lys Gly Val Glu Asn Asp Leu 
    850                 855                 860                 


Ser Tyr Gln Asn Ile Glu Glu Glu Ile Val Glu Leu Pro Asp Leu Asp 
865                 870                 875                 880 


Tyr Leu Arg Thr Met Thr His Ile Val Phe Val Asp Phe Asp Asn Trp 
                885                 890                 895     


Ser Asn Phe Phe Gly His Leu Pro Gly His Leu Asn Gln Gly Thr Phe 
            900                 905                 910         


Ile Trp Gly Phe Gln Gly Gly Asn Thr Asn Trp Lys Pro Pro Leu Asn 
        915                 920                 925             


Cys Lys Ile Tyr Asn Tyr Leu Asn Arg Ile Gly Cys Phe Phe Leu His 
    930                 935                 940                 


Pro Arg Cys Ser Lys Arg Lys Asp Ala Ala Asp Phe Ala Ile Cys Met 
945                 950                 955                 960 


His Ala Gly Arg Leu Asp Glu Gln Leu Pro Lys Gln Ile Pro Phe Thr 
                965                 970                 975     


Ile Leu Ser Gly Asp Gln Gly Phe Leu Glu Leu Glu Asn Gln Phe Lys 
            980                 985                 990         


Lys Thr Gln Arg Pro Ala His Ile  Leu Asn Pro His His  Leu Glu Gly 
        995                 1000                 1005             


Asp Met  Met Cys Ala Leu Leu  Asn Ser Ile Ser Asp  Thr Thr Lys 
    1010                 1015                 1020             


Glu Cys  Asp Ser Asp Asp Asn  Met Gly Ala Lys Asn  Thr Ser Ile 
    1025                 1030                 1035             


Gly Glu  Glu Phe Ile Ser Thr  Glu Asp Val Glu Leu  Glu Glu Ala 
    1040                 1045                 1050             


Ile Arg  Arg Ser Leu Glu Glu  Met 
    1055                 1060     


<210>  1811
<211>  5097
<212>  DNA
<213>  Homosapiens

<400>  1811
ggaagcccgg gagtgagaga aagcggctcc gggggcatag cgggccagta agggccgctc     60

ctcctttgaa gaggttttgc gtctctttcc gccggtggcg tcggcgctca cgcaggggcg    120

ggtcccggta gcgccaggcg gtgcagggcg ggaaggggat tcgtggcgac ggcggcggca    180

gggacagcag gagcagtggt gctgtcagcg cggccgtcgg agacatggga gacccggggt    240

cggagataat agaatctgtc cctccagctg gccctgaggc atctgagtca acaacggatg    300

aaaatgaaga cgacattcag tttgtcagtg aaggaccatt acgacctgtt cttgaataca    360

ttgatctggt cagcagtgat gatgaagagc ctagcacctc ttatactgat gagaatatta    420

aacgtaaaga ccatattgat tatcagaagg ataaagttgc tttaactctg gctcgtctag    480

cccgccatgt tgaagtggag aaacagcaga aagaagagaa gaatagagca ttcagagaaa    540

aaattgattt tcagcatgct catgggttac aagaattgga atttattcga ggacattctg    600

atacagaagc agcaagactg tgtgtggacc agtggctaaa aatgccagga ctcaaaacag    660

gcacaattaa ttgtggaaca aaaagttcat tccgaagagg aggccacacg tgggtgtctg    720

ggaaaccaat tttatgtcct ataatgcact gtaacaagga gtttgacaat gggcaccttc    780

tcttaggaca tttgaaaagg ttcgatcact ctccatgtga tccaacaatt acactacatg    840

gacctttctt cagctccttt gcttgtgtag tatgttataa aaaatttgtt actcaacaac    900

aatatagaga tcaccttttt gataaggaag ccacagatga tggacataac aacaaccttc    960

ttcctcagat tattcagtgt tttgcatgtc caaattgctt ccttcttttt agcagaaagg   1020

aggagtgttc aaagcatatg tctggaaaga atcatttcca tcagagtttc aaactgggtg   1080

ataacaaagg aattgcacat ccaatatctt tcccatcttt tgcaaagaaa cttttgatct   1140

ctctgtgcaa agatgttccc tttcaagtta agtgtgtggc ctgccacaag acactgcgtt   1200

cccacatgga gctcactgcc catttcagag ttcattgtcg aaatgctgga cctgtagctg   1260

tagctgagaa gagcattacc caggttgcag agaaattcat attaagaggt tattgtccag   1320

attgcaatca agtctttgtg gatgaaacca gcacccaaaa tcataagcag aattcaggac   1380

acaaagtccg agtcattaac tcagtggaag aatcagtctt actctattgc cacagcagcg   1440

aagggaacaa ggatccttct tctgacttgc atttattgtt ggatcaatca aaattttcat   1500

cacttaaaag aaccatgtct attaaagaat ctagctcact ggagtgcatt gccattccaa   1560

aaaagaagat gaatttaaaa gataaaagcc atgaaggtgt tgcttgtgtc cagaaagaaa   1620

aatcagtagt taaaacctgg ttctgtgaat gcaatcagcg attcccaagt gaagatgcag   1680

tagaaaagca tgttttctca gcaaacacaa tgggttataa atgtgtggtc tgtggaaagg   1740

tatgtgatga ttcaggggtc attcgtttac acatgagccg gattcacgga ggggcacatt   1800

taaataactt tcttttctgg tgtcggacat gcaaaaagga gttaacaagg aaagatacta   1860

tcatggcaca tgtgactgaa tttcataatg gacacagata tttttatgag atggatgagg   1920

tagaaggtga aactttgcca tcatcctcta caacattgga taatttgact gctaacaagc   1980

cttcatcagc tattactgtt attgatcatt ccccggcaaa tagttctccg aggggtaaat   2040

ggcaatgccg gatttgtgaa gatatgtttg attcccagga atatgtaaaa cagcactgca   2100

tgtctttggc aagccacaag tttcatagat acagctgtgc tcactgcaga aagccttttc   2160

ataagataga aacattgtac cgacattgcc aagatgagca tgacaatgag ataaagatta   2220

aatacttctg tgggctttgt gatcttatct ttaatgtgga agaagcattt ctgagtcatt   2280

atgaggagca ccacagcata gattatgtat ttgtgtcaga aaaaactgaa acttcaatta   2340

aaaccgaaga tgattttcca gtaatagaga ccagtaacca gttaacttgt ggttgccgtg   2400

agagttacat ctgtaaagtc aacagaaaag aagattatag cagatgtctc caaatcatgc   2460

tggataaagg aaaactgtgg tttcgctgca gtttatgttc ggcaacagca cagaatttaa   2520

ccgacatgaa cactcatatc catcaagtgc acaaagaaaa gagtgatgag gaggagcagc   2580

agtatgtaat caagtgtggc acctgcacca aagcatttca tgatcctgag agtgcacagc   2640

agcatttcca tagaaaacat tgcttcttac agaaacccag tgtggctcat tttggatctg   2700

aaaaatcaaa cctgtacaag tttactgcta gtgcctcaca tacagagaga aaactgaaac   2760

aggcaataaa ctattcaaaa agtttagaca tggagaaagg agttgagaat gacctaagct   2820

atcagaatat aggaggaaac accaattgga agcctccgct caactgtaag atttataact   2880

acctgaacag gattggatgc ttcttccttc atcctcgctg tagtaaaaga aaagatgctg   2940

ctgattttgc catatgtatg catgctggcc gtctagatga acaactaccc aagcaaattc   3000

ctttcaccat cctctcagga gatcaaggtt ttctggagct agagaatcaa tttaagaaga   3060

ctcagaggcc agctcatata ctaaaccctc accacttaga gggagatatg atgtgtgcct   3120

tgttaaatag catatctgat accaccaaag aatgtgacag tgatgataac atgggtgcca   3180

aaaatacttc aataggagaa gaatttatat ccacagaaga tgtggaatta gaagaagcta   3240

ttagaagaag tcttgaggaa atgtaattaa agatattacc acacaacatc aagtggcctt   3300

gaagagactg agataacgaa ttcttgagtt tgttttctaa aggagaccag aaatccacta   3360

ttacaaatgt atttgaaaac atgtttttgc tttcatatgt tcaaaatctg atctttgttt   3420

tgtatttttg tgctaatgtg caaacatgta cagaagaaat agaatacatg ttcatgcaaa   3480

tataaattat gtattctaat ataggtgtaa cagtttccca gttaactttg aatttatata   3540

tttagattta aaggattaaa aaaaaggaaa gctcttgaca gttgtttccc aaatagcatt   3600

agttctttaa ttttatttgt actgtacaaa tgatgctagt ttattttttt agcagtgaaa   3660

atgaatataa aaaaggtgac ataggtcaag ttttccataa attctacttc tcatgtggca   3720

ctattatata atacctttga gatctttgtt tatgtttatt agaagagggt aatggaaact   3780

gatcatggaa acatttaaaa ttttatcagc aatgttcttt gtgggtgcca tgcatatgta   3840

aattattgct ttaattagag cagcacattg ctaaaataaa aaatacacct taatttttaa   3900

gaaataattt aaatgaaaca atttccattc cttttacctg cttagacttt tatgtgactt   3960

gtatggtctc ctggttaaag ggaatggtgt cagaatattt gcataaaatt atttttcata   4020

acagtccttt tttatatatt ggtgtaaaca taatattctt caagaaataa tgttgaaagc   4080

ctactcagga ataatcttcc ttaactcttt aaatttttat ttcatgtgaa gtgttttcag   4140

tttagttatt cactgaattg tcagtttcct tcatttggta ttacatattt aattcttaaa   4200

tattgaggcc ccattgtgag taataaaaaa tacgacataa gtagaagact aagaagggct   4260

tgtcatatta tctttgtgta tatgcttcat gttatttaac cagaaatgtc ttatctctaa   4320

aaatttttag tagtaattat ttaccaaact taaaaacatt tctataaata taaagctttt   4380

ctttatattt aagacaaaat ataaaggcta gaatttggtt ccttctctgt aacactaaat   4440

attttagtgt gaaattgaat ttttttatta ctatagtctt ttcaatctat aatttgtgtt   4500

tttaatttct tgatatgtca cttctgttcc tccctgcttg cattttttaa aaactagaca   4560

ttgtggcttg agaatttatc aatcatcttt ccgaaatgac cacattgtgc ttttagtttg   4620

tatgtttaag tggtcaagca aggctctagg aggtagtcac tgagctggac cttaaacaca   4680

tctgcaggag ctcacaaaat gggagcaaaa gaggcattcc agaaagaaga gtagttaagc   4740

agatgtgggg gcagggcaag aggagacagc accttgttgc cagagattct acacaaaggt   4800

gtgatggaca ctgatgctct attaagaagc ttttgtggtg tgtgtggtag agaataatta   4860

aggcttctga taagacagga aagggatatt tcatcatgac tgttaagaaa aggtaactgg   4920

gttgtttaat gttttaattg ataattgtca ctgatcgtat ttctacttgt taaataatta   4980

aaaatcatct taaaattcat actttgactt taatttagac acaaggagat gtaatcgctg   5040

tgtaacatca gagaaagcta tatggattat cgtcagaagt aaatgtttct aacattg      5097


<210>  1812
<211>  1013
<212>  PRT
<213>  Homosapiens

<400>  1812

Met Gly Asp Pro Gly Ser Glu Ile Ile Glu Ser Val Pro Pro Ala Gly 
1               5                   10                  15      


Pro Glu Ala Ser Glu Ser Thr Thr Asp Glu Asn Glu Asp Asp Ile Gln 
            20                  25                  30          


Phe Val Ser Glu Gly Pro Leu Arg Pro Val Leu Glu Tyr Ile Asp Leu 
        35                  40                  45              


Val Ser Ser Asp Asp Glu Glu Pro Ser Thr Ser Tyr Thr Asp Glu Asn 
    50                  55                  60                  


Ile Lys Arg Lys Asp His Ile Asp Tyr Gln Lys Asp Lys Val Ala Leu 
65                  70                  75                  80  


Thr Leu Ala Arg Leu Ala Arg His Val Glu Val Glu Lys Gln Gln Lys 
                85                  90                  95      


Glu Glu Lys Asn Arg Ala Phe Arg Glu Lys Ile Asp Phe Gln His Ala 
            100                 105                 110         


His Gly Leu Gln Glu Leu Glu Phe Ile Arg Gly His Ser Asp Thr Glu 
        115                 120                 125             


Ala Ala Arg Leu Cys Val Asp Gln Trp Leu Lys Met Pro Gly Leu Lys 
    130                 135                 140                 


Thr Gly Thr Ile Asn Cys Gly Thr Lys Ser Ser Phe Arg Arg Gly Gly 
145                 150                 155                 160 


His Thr Trp Val Ser Gly Lys Pro Ile Leu Cys Pro Ile Met His Cys 
                165                 170                 175     


Asn Lys Glu Phe Asp Asn Gly His Leu Leu Leu Gly His Leu Lys Arg 
            180                 185                 190         


Phe Asp His Ser Pro Cys Asp Pro Thr Ile Thr Leu His Gly Pro Phe 
        195                 200                 205             


Phe Ser Ser Phe Ala Cys Val Val Cys Tyr Lys Lys Phe Val Thr Gln 
    210                 215                 220                 


Gln Gln Tyr Arg Asp His Leu Phe Asp Lys Glu Ala Thr Asp Asp Gly 
225                 230                 235                 240 


His Asn Asn Asn Leu Leu Pro Gln Ile Ile Gln Cys Phe Ala Cys Pro 
                245                 250                 255     


Asn Cys Phe Leu Leu Phe Ser Arg Lys Glu Glu Cys Ser Lys His Met 
            260                 265                 270         


Ser Gly Lys Asn His Phe His Gln Ser Phe Lys Leu Gly Asp Asn Lys 
        275                 280                 285             


Gly Ile Ala His Pro Ile Ser Phe Pro Ser Phe Ala Lys Lys Leu Leu 
    290                 295                 300                 


Ile Ser Leu Cys Lys Asp Val Pro Phe Gln Val Lys Cys Val Ala Cys 
305                 310                 315                 320 


His Lys Thr Leu Arg Ser His Met Glu Leu Thr Ala His Phe Arg Val 
                325                 330                 335     


His Cys Arg Asn Ala Gly Pro Val Ala Val Ala Glu Lys Ser Ile Thr 
            340                 345                 350         


Gln Val Ala Glu Lys Phe Ile Leu Arg Gly Tyr Cys Pro Asp Cys Asn 
        355                 360                 365             


Gln Val Phe Val Asp Glu Thr Ser Thr Gln Asn His Lys Gln Asn Ser 
    370                 375                 380                 


Gly His Lys Val Arg Val Ile Asn Ser Val Glu Glu Ser Val Leu Leu 
385                 390                 395                 400 


Tyr Cys His Ser Ser Glu Gly Asn Lys Asp Pro Ser Ser Asp Leu His 
                405                 410                 415     


Leu Leu Leu Asp Gln Ser Lys Phe Ser Ser Leu Lys Arg Thr Met Ser 
            420                 425                 430         


Ile Lys Glu Ser Ser Ser Leu Glu Cys Ile Ala Ile Pro Lys Lys Lys 
        435                 440                 445             


Met Asn Leu Lys Asp Lys Ser His Glu Gly Val Ala Cys Val Gln Lys 
    450                 455                 460                 


Glu Lys Ser Val Val Lys Thr Trp Phe Cys Glu Cys Asn Gln Arg Phe 
465                 470                 475                 480 


Pro Ser Glu Asp Ala Val Glu Lys His Val Phe Ser Ala Asn Thr Met 
                485                 490                 495     


Gly Tyr Lys Cys Val Val Cys Gly Lys Val Cys Asp Asp Ser Gly Val 
            500                 505                 510         


Ile Arg Leu His Met Ser Arg Ile His Gly Gly Ala His Leu Asn Asn 
        515                 520                 525             


Phe Leu Phe Trp Cys Arg Thr Cys Lys Lys Glu Leu Thr Arg Lys Asp 
    530                 535                 540                 


Thr Ile Met Ala His Val Thr Glu Phe His Asn Gly His Arg Tyr Phe 
545                 550                 555                 560 


Tyr Glu Met Asp Glu Val Glu Gly Glu Thr Leu Pro Ser Ser Ser Thr 
                565                 570                 575     


Thr Leu Asp Asn Leu Thr Ala Asn Lys Pro Ser Ser Ala Ile Thr Val 
            580                 585                 590         


Ile Asp His Ser Pro Ala Asn Ser Ser Pro Arg Gly Lys Trp Gln Cys 
        595                 600                 605             


Arg Ile Cys Glu Asp Met Phe Asp Ser Gln Glu Tyr Val Lys Gln His 
    610                 615                 620                 


Cys Met Ser Leu Ala Ser His Lys Phe His Arg Tyr Ser Cys Ala His 
625                 630                 635                 640 


Cys Arg Lys Pro Phe His Lys Ile Glu Thr Leu Tyr Arg His Cys Gln 
                645                 650                 655     


Asp Glu His Asp Asn Glu Ile Lys Ile Lys Tyr Phe Cys Gly Leu Cys 
            660                 665                 670         


Asp Leu Ile Phe Asn Val Glu Glu Ala Phe Leu Ser His Tyr Glu Glu 
        675                 680                 685             


His His Ser Ile Asp Tyr Val Phe Val Ser Glu Lys Thr Glu Thr Ser 
    690                 695                 700                 


Ile Lys Thr Glu Asp Asp Phe Pro Val Ile Glu Thr Ser Asn Gln Leu 
705                 710                 715                 720 


Thr Cys Gly Cys Arg Glu Ser Tyr Ile Cys Lys Val Asn Arg Lys Glu 
                725                 730                 735     


Asp Tyr Ser Arg Cys Leu Gln Ile Met Leu Asp Lys Gly Lys Leu Trp 
            740                 745                 750         


Phe Arg Cys Ser Leu Cys Ser Ala Thr Ala Gln Asn Leu Thr Asp Met 
        755                 760                 765             


Asn Thr His Ile His Gln Val His Lys Glu Lys Ser Asp Glu Glu Glu 
    770                 775                 780                 


Gln Gln Tyr Val Ile Lys Cys Gly Thr Cys Thr Lys Ala Phe His Asp 
785                 790                 795                 800 


Pro Glu Ser Ala Gln Gln His Phe His Arg Lys His Cys Phe Leu Gln 
                805                 810                 815     


Lys Pro Ser Val Ala His Phe Gly Ser Glu Lys Ser Asn Leu Tyr Lys 
            820                 825                 830         


Phe Thr Ala Ser Ala Ser His Thr Glu Arg Lys Leu Lys Gln Ala Ile 
        835                 840                 845             


Asn Tyr Ser Lys Ser Leu Asp Met Glu Lys Gly Val Glu Asn Asp Leu 
    850                 855                 860                 


Ser Tyr Gln Asn Ile Gly Gly Asn Thr Asn Trp Lys Pro Pro Leu Asn 
865                 870                 875                 880 


Cys Lys Ile Tyr Asn Tyr Leu Asn Arg Ile Gly Cys Phe Phe Leu His 
                885                 890                 895     


Pro Arg Cys Ser Lys Arg Lys Asp Ala Ala Asp Phe Ala Ile Cys Met 
            900                 905                 910         


His Ala Gly Arg Leu Asp Glu Gln Leu Pro Lys Gln Ile Pro Phe Thr 
        915                 920                 925             


Ile Leu Ser Gly Asp Gln Gly Phe Leu Glu Leu Glu Asn Gln Phe Lys 
    930                 935                 940                 


Lys Thr Gln Arg Pro Ala His Ile Leu Asn Pro His His Leu Glu Gly 
945                 950                 955                 960 


Asp Met Met Cys Ala Leu Leu Asn Ser Ile Ser Asp Thr Thr Lys Glu 
                965                 970                 975     


Cys Asp Ser Asp Asp Asn Met Gly Ala Lys Asn Thr Ser Ile Gly Glu 
            980                 985                 990         


Glu Phe Ile Ser Thr Glu Asp Val  Glu Leu Glu Glu Ala  Ile Arg Arg 
        995                 1000                 1005             


Ser Leu  Glu Glu Met 
    1010             


<210>  1813
<211>  1556
<212>  DNA
<213>  Homosapiens

<400>  1813
gcagccgcgg tgtcgcgaag tcctcccggg ttgcccccgc ggcgtcagag ggagggcggg     60

cgccgcgttg gtgacggcga ccctgcagcc caaggagcgc tccactcgct gccgccggag    120

ggccggtgac ctcttggcta ccccgcgtcg gaggcttaga tggctcaggc gaagatcaac    180

gctaaagcca acgaggggcg cttctgccgc tcctcctcca tggctgaccg ctccagccgc    240

ctgctggaga gcctggacca gctggagctc agggttgaag ctttgagaga agcagcaact    300

gctgttgagc aagagaaaga aatccttctg gaaatgatcc acagtatcca aaatagccag    360

gacatgaggc agatcagtga cggagaaaga gaagaattaa atctgactgc aaaccgtttg    420

atgggaagaa ctctcaccgt tgaagtgtca gtagaaacaa ttagaaaccc ccagcagcaa    480

gaatccctaa agcatgccac aaggattatt gatgaggtgg tcaataagtt tctggatgat    540

ttgggaaatg ccaagagtca tttaatgtcg ctctacagtg catgttcatc tgaggtgcca    600

catgggccag ttgatcagaa gtttcaatcc atagtaattg gctgtgctct tgaagatcag    660

aagaaaatta agagaagatt agagactctg cttagaaata ttgaaaactc tgacaaggcc    720

atcaagctat tagagcattc taaaggagct ggttccaaaa ctctgcaaca aaatgctgaa    780

agcagattca attagtcttc aaacctaaga gcatttacac aatacacaag gtgtaaaaat    840

gataaaatac tattttaatt gataactagt tctttgttag gtataaccac ttagttgaca    900

ctgatagttg tttcagatga ggaaaatatt ccatcaagta tcttcagttt tgtgaataac    960

aaaactagca atattttaat tatctatcta gagatttttt agattgaatt cttgtcttgt   1020

actaggatct agcatatttc actattctgt ggatgaatac atagtttgtg gggaaaacaa   1080

acgttcagct aggggcaaaa agcatgactg ctttttcctg tctggcatgg aatcacgcag   1140

tcaccttggg catttagttt actagaaatt ctttactgaa gcagcacaca catttactac   1200

acacacagtg ttaacaaagc actgtgctta gagggtaaaa aggaatcaca aaacaagaat   1260

ctttccaaag ttgtctcatt cagcaatgtt aaggcatctg tatcaaatta ttttggatgt   1320

aaagattcct gtgtctcata atatgaatgt attttttgat atacaagaaa ctgacataaa   1380

atgtgagaaa accacctata atttaccact gtgaacaatt atatatctat ctgcttcatc   1440

ttttctcaaa tgcatcaatt ctctaaaatt cctatattgt aacttgcctt tttttaaaaa   1500

agttagatgc tgatataaag tctgcttaat tgtcaactta aaaaaaaaaa aaaaaa       1556


<210>  1814
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  1814

Met Ala Gln Ala Lys Ile Asn Ala Lys Ala Asn Glu Gly Arg Phe Cys 
1               5                   10                  15      


Arg Ser Ser Ser Met Ala Asp Arg Ser Ser Arg Leu Leu Glu Ser Leu 
            20                  25                  30          


Asp Gln Leu Glu Leu Arg Val Glu Ala Leu Arg Glu Ala Ala Thr Ala 
        35                  40                  45              


Val Glu Gln Glu Lys Glu Ile Leu Leu Glu Met Ile His Ser Ile Gln 
    50                  55                  60                  


Asn Ser Gln Asp Met Arg Gln Ile Ser Asp Gly Glu Arg Glu Glu Leu 
65                  70                  75                  80  


Asn Leu Thr Ala Asn Arg Leu Met Gly Arg Thr Leu Thr Val Glu Val 
                85                  90                  95      


Ser Val Glu Thr Ile Arg Asn Pro Gln Gln Gln Glu Ser Leu Lys His 
            100                 105                 110         


Ala Thr Arg Ile Ile Asp Glu Val Val Asn Lys Phe Leu Asp Asp Leu 
        115                 120                 125             


Gly Asn Ala Lys Ser His Leu Met Ser Leu Tyr Ser Ala Cys Ser Ser 
    130                 135                 140                 


Glu Val Pro His Gly Pro Val Asp Gln Lys Phe Gln Ser Ile Val Ile 
145                 150                 155                 160 


Gly Cys Ala Leu Glu Asp Gln Lys Lys Ile Lys Arg Arg Leu Glu Thr 
                165                 170                 175     


Leu Leu Arg Asn Ile Glu Asn Ser Asp Lys Ala Ile Lys Leu Leu Glu 
            180                 185                 190         


His Ser Lys Gly Ala Gly Ser Lys Thr Leu Gln Gln Asn Ala Glu Ser 
        195                 200                 205             


Arg Phe Asn 
    210     


<210>  1815
<211>  3037
<212>  DNA
<213>  Homosapiens

<400>  1815
atgaggggag tcgagactcc cgcgccccac cacccccggc ggagctgctg ctgagccact     60

caatctgagc cctggctact aataaagttc gtttaaaaat cataatcatt cttaagagag    120

cgaaagaggg tgcgaactag ccgctcggcc ccgcagggag agctggcgcg tcgggaggag    180

acagcggcgg cagcggttgc gccgcgacca ggaggagccg gtggcgccgg gcggcgggtc    240

cgcggccggt gggggacggt gagtagcggc tcgcgctgcg gtgcagcggc gctgcactca    300

ctcgccctct ccaggggctg ggggttcgtc cggctccact ggggaagact cagcttctcc    360

ccggggtccc gggttgtgcc ttactctccg gagtgggcag gggtatcgag ggcaggggcc    420

tcccggcccg gctcccccat cccccggttc ggaccgccga gcgccggctc tcccctccct    480

gagcaccgat cccaagttcc agctagagaa ggtgggcggc agcgccagcc cggcgccccc    540

tcccagctcc cagcgatttg agagggaaga tctgatctcc tagaattaga gttggtacag    600

aaaccatttc agctccaaaa atgttggagg aagatatgga agtcgccata aagatggtgg    660

ttgtagggaa tggagcagtt ggaaaatcaa gtatgattca gcgatattgc aaaggcattt    720

ttacaaaaga ctacaagaaa accattggag ttgatttttt ggagcgacaa attcaagtta    780

atgatgaaga tgtcagacta atgttatggg acactgcagg tcaggaggaa tttgatgcaa    840

ttacaaaggc ctactatcga ggagcccagg cttgtgtgct cgtgttctct accacagata    900

gggaatcttt tgaagcagtt tccagttgga gagagaaagt agtagccgaa gtgggagata    960

taccaactgt acttgtgcaa aacaagattg atcttctgga tgattcttgt ataaagaatg   1020

aggaagctga ggcactggca aaaaggttaa agttaagatt ctacagaaca tcagtgaaag   1080

aagatctaaa tgtgaatgaa gtttttaagt atttggctga aaaatacctt cagaaactca   1140

aacaacaaat agctgaggat ccagaactaa cgcattcaag tagtaacaag attggtgtct   1200

ttaatacatc tggtggaagt cactccggtc agaattcagg taccctcaat ggtggagatg   1260

tcatcaatct tagacccaac aaacaaagga ccaagaaaaa cagaaatcct tttagcagct   1320

gtagcatacc ctaagatgtt ttgggaggaa aacaattgaa ttacattgtg caatgcatta   1380

agaaacccat ccagctgtca tggtatgtta caaggttttc agcagacttt gctcctaatg   1440

gctctctgaa agtgacagac ttaaatattg ctctgcagtg cttttcagaa tgtagagtga   1500

gacctctggt ggaaaaatta ttgccctgtg gactccttta atttttttta cattagacga   1560

agcttctcct gtttgtaaag gaatgctata agaaatttca aacacaggtt ttgcggaatt   1620

ttaaatgctg gaaaacataa atgaaatgcc taaatatatt gttacagatt ttaatactgt   1680

ggatcaagga aagatagcaa gcattctttt cctgaaattg gtcatgtagc ttttctgcga   1740

aatagtattg aatctgaata ctttcacaaa ataatactga aaggtaaacc ctaaatcttg   1800

ccagactgca ttagtatttt ggcattgaaa cttgtgcaat atctgtgtaa tgtagaatgt   1860

ggggtgtgca tgcagatgtc tggtactgga gtaagctgaa ggtatgtgca gtatttaaga   1920

aaatgtacat tctaattaat tcacttataa aaccatttac atattgtgta tatgttttta   1980

ttttcaaatg ataaactcta gacatatatt ttgcaaaatg agcttgggtt taaaaagtgc   2040

tttgtgccaa aaatatcata cctaattttt atagtgcttt actatcagaa tttatattgt   2100

ttattatatc ttttaaaagc agtaagcagt tttcatctga cagcgtagat aaaagaggag   2160

tataggaatt tgaatgctag agcatctccc aggtgagcct tattgcagat ctttttgata   2220

tagtcaccca taagcatggt gagctcctgc tctcataagg tcagccaaag ccccttaaga   2280

aggtacacag cacatctgca gtcattcagg aggtcctgtg aagtgtggtg atgcatctaa   2340

caccttttgc tgctcactga gaacccagct ttgaacttac aagattacac taaccatttt   2400

taaagtgcac aaaaatatta ttattagtct taactaaaat tacatatttt ataatgccct   2460

gcaactctaa accatccttt tgtttacaca tttttgtatg gtattttaag attatcaatc   2520

acttcaacat ttctataacc ttgtttgtat agcactttct caagagctgt cagtcccaca   2580

tacagaatca tttcttttac aaaatgattt aatatgtaat catgtgtcag gacataaatt   2640

ttgtcacttg ggacagtagc tttccagcta agataattgc gtgaactctg ttaaaactga   2700

ttatcactca tcaatggctt tatttttaac ctataaataa cccctttcaa tatacctggt   2760

ttttacagca ttgcaaaatc tgtaaaaata acttttattg gaaaatgtca tgaagtcatt   2820

tttcattatt tgtactaaac aatgttttat gtactccttt tgtgttttat cttttgtttt   2880

tccatctgta ctcccctcat cctcctaatg ttgagaaaat caaatttcct gggtgtgtcc   2940

ttgttaagtg atcaaaagta aatgttctct ttgccatttt agatggaaaa ataaaaaaaa   3000

ttaaaaagta aaaaaaaaaa aaaaaaaaaa aaaaaaa                            3037


<210>  1816
<211>  237
<212>  PRT
<213>  Homosapiens

<400>  1816

Met Leu Glu Glu Asp Met Glu Val Ala Ile Lys Met Val Val Val Gly 
1               5                   10                  15      


Asn Gly Ala Val Gly Lys Ser Ser Met Ile Gln Arg Tyr Cys Lys Gly 
            20                  25                  30          


Ile Phe Thr Lys Asp Tyr Lys Lys Thr Ile Gly Val Asp Phe Leu Glu 
        35                  40                  45              


Arg Gln Ile Gln Val Asn Asp Glu Asp Val Arg Leu Met Leu Trp Asp 
    50                  55                  60                  


Thr Ala Gly Gln Glu Glu Phe Asp Ala Ile Thr Lys Ala Tyr Tyr Arg 
65                  70                  75                  80  


Gly Ala Gln Ala Cys Val Leu Val Phe Ser Thr Thr Asp Arg Glu Ser 
                85                  90                  95      


Phe Glu Ala Val Ser Ser Trp Arg Glu Lys Val Val Ala Glu Val Gly 
            100                 105                 110         


Asp Ile Pro Thr Val Leu Val Gln Asn Lys Ile Asp Leu Leu Asp Asp 
        115                 120                 125             


Ser Cys Ile Lys Asn Glu Glu Ala Glu Ala Leu Ala Lys Arg Leu Lys 
    130                 135                 140                 


Leu Arg Phe Tyr Arg Thr Ser Val Lys Glu Asp Leu Asn Val Asn Glu 
145                 150                 155                 160 


Val Phe Lys Tyr Leu Ala Glu Lys Tyr Leu Gln Lys Leu Lys Gln Gln 
                165                 170                 175     


Ile Ala Glu Asp Pro Glu Leu Thr His Ser Ser Ser Asn Lys Ile Gly 
            180                 185                 190         


Val Phe Asn Thr Ser Gly Gly Ser His Ser Gly Gln Asn Ser Gly Thr 
        195                 200                 205             


Leu Asn Gly Gly Asp Val Ile Asn Leu Arg Pro Asn Lys Gln Arg Thr 
    210                 215                 220                 


Lys Lys Asn Arg Asn Pro Phe Ser Ser Cys Ser Ile Pro 
225                 230                 235         


<210>  1817
<211>  2623
<212>  DNA
<213>  Homosapiens

<400>  1817
ttcttgttca tagagtgctg gaatatgaat gagccaaatt gtgctgttcc attgacactg     60

gttgctacag aattaacttt actcggagat ccgaggagcc atcggcagtt cccaggagta    120

agaacctgag agcgtgtgag aatttgagag ggaagatctg atctcctaga attagagttg    180

gtacagaaac catttcagct ccaaaaatgt tggaggaaga tatggaagtc gccataaaga    240

tggtggttgt agggaatgga gcagttggaa aatcaagtat gattcagcga tattgcaaag    300

gcatttttac aaaagactac aagaaaacca ttggagttga ttttttggag cgacaaattc    360

aagttaatga tgaagatgtc agactaatgt tatgggacac tgcaggtcag gaggaatttg    420

atgcaattac aaaggcctac tatcgaggag cccaggcttg tgtgctcgtg ttctctacca    480

cagataggga atcttttgaa gcagtttcca gttggagaga gaaagtagta gccgaagtgg    540

gagatatacc aactgtactt gtgcaaaaca agattgatct tctggatgat tcttgtataa    600

agaatgagga agctgaggca ctggcaaaaa ggttaaagtt aagattctac agaacatcag    660

tgaaagaaga tctaaatgtg aatgaagttt ttaagtattt ggctgaaaaa taccttcaga    720

aactcaaaca acaaatagct gaggatccag aactaacgca ttcaagtagt aacaagattg    780

gtgtctttaa tacatctggt ggaagtcact ccggtcagaa ttcaggtacc ctcaatggtg    840

gagatgtcat caatcttaga cccaacaaac aaaggaccaa gaaaaacaga aatcctttta    900

gcagctgtag cataccctaa gatgttttgg gaggaaaaca attgaattac attgtgcaat    960

gcattaagaa acccatccag ctgtcatggt atgttacaag gttttcagca gactttgctc   1020

ctaatggctc tctgaaagtg acagacttaa atattgctct gcagtgcttt tcagaatgta   1080

gagtgagacc tctggtggaa aaattattgc cctgtggact cctttaattt tttttacatt   1140

agacgaagct tctcctgttt gtaaaggaat gctataagaa atttcaaaca caggttttgc   1200

ggaattttaa atgctggaaa acataaatga aatgcctaaa tatattgtta cagattttaa   1260

tactgtggat caaggaaaga tagcaagcat tcttttcctg aaattggtca tgtagctttt   1320

ctgcgaaata gtattgaatc tgaatacttt cacaaaataa tactgaaagg taaaccctaa   1380

atcttgccag actgcattag tattttggca ttgaaacttg tgcaatatct gtgtaatgta   1440

gaatgtgggg tgtgcatgca gatgtctggt actggagtaa gctgaaggta tgtgcagtat   1500

ttaagaaaat gtacattcta attaattcac ttataaaacc atttacatat tgtgtatatg   1560

tttttatttt caaatgataa actctagaca tatattttgc aaaatgagct tgggtttaaa   1620

aagtgctttg tgccaaaaat atcataccta atttttatag tgctttacta tcagaattta   1680

tattgtttat tatatctttt aaaagcagta agcagttttc atctgacagc gtagataaaa   1740

gaggagtata ggaatttgaa tgctagagca tctcccaggt gagccttatt gcagatcttt   1800

ttgatatagt cacccataag catggtgagc tcctgctctc ataaggtcag ccaaagcccc   1860

ttaagaaggt acacagcaca tctgcagtca ttcaggaggt cctgtgaagt gtggtgatgc   1920

atctaacacc ttttgctgct cactgagaac ccagctttga acttacaaga ttacactaac   1980

catttttaaa gtgcacaaaa atattattat tagtcttaac taaaattaca tattttataa   2040

tgccctgcaa ctctaaacca tccttttgtt tacacatttt tgtatggtat tttaagatta   2100

tcaatcactt caacatttct ataaccttgt ttgtatagca ctttctcaag agctgtcagt   2160

cccacataca gaatcatttc ttttacaaaa tgatttaata tgtaatcatg tgtcaggaca   2220

taaattttgt cacttgggac agtagctttc cagctaagat aattgcgtga actctgttaa   2280

aactgattat cactcatcaa tggctttatt tttaacctat aaataacccc tttcaatata   2340

cctggttttt acagcattgc aaaatctgta aaaataactt ttattggaaa atgtcatgaa   2400

gtcatttttc attatttgta ctaaacaatg ttttatgtac tccttttgtg ttttatcttt   2460

tgtttttcca tctgtactcc cctcatcctc ctaatgttga gaaaatcaaa tttcctgggt   2520

gtgtccttgt taagtgatca aaagtaaatg ttctctttgc cattttagat ggaaaaataa   2580

aaaaaattaa aaagtaaaaa aaaaaaaaaa aaaaaaaaaa aaa                     2623


<210>  1818
<211>  237
<212>  PRT
<213>  Homosapiens

<400>  1818

Met Leu Glu Glu Asp Met Glu Val Ala Ile Lys Met Val Val Val Gly 
1               5                   10                  15      


Asn Gly Ala Val Gly Lys Ser Ser Met Ile Gln Arg Tyr Cys Lys Gly 
            20                  25                  30          


Ile Phe Thr Lys Asp Tyr Lys Lys Thr Ile Gly Val Asp Phe Leu Glu 
        35                  40                  45              


Arg Gln Ile Gln Val Asn Asp Glu Asp Val Arg Leu Met Leu Trp Asp 
    50                  55                  60                  


Thr Ala Gly Gln Glu Glu Phe Asp Ala Ile Thr Lys Ala Tyr Tyr Arg 
65                  70                  75                  80  


Gly Ala Gln Ala Cys Val Leu Val Phe Ser Thr Thr Asp Arg Glu Ser 
                85                  90                  95      


Phe Glu Ala Val Ser Ser Trp Arg Glu Lys Val Val Ala Glu Val Gly 
            100                 105                 110         


Asp Ile Pro Thr Val Leu Val Gln Asn Lys Ile Asp Leu Leu Asp Asp 
        115                 120                 125             


Ser Cys Ile Lys Asn Glu Glu Ala Glu Ala Leu Ala Lys Arg Leu Lys 
    130                 135                 140                 


Leu Arg Phe Tyr Arg Thr Ser Val Lys Glu Asp Leu Asn Val Asn Glu 
145                 150                 155                 160 


Val Phe Lys Tyr Leu Ala Glu Lys Tyr Leu Gln Lys Leu Lys Gln Gln 
                165                 170                 175     


Ile Ala Glu Asp Pro Glu Leu Thr His Ser Ser Ser Asn Lys Ile Gly 
            180                 185                 190         


Val Phe Asn Thr Ser Gly Gly Ser His Ser Gly Gln Asn Ser Gly Thr 
        195                 200                 205             


Leu Asn Gly Gly Asp Val Ile Asn Leu Arg Pro Asn Lys Gln Arg Thr 
    210                 215                 220                 


Lys Lys Asn Arg Asn Pro Phe Ser Ser Cys Ser Ile Pro 
225                 230                 235         


<210>  1819
<211>  2353
<212>  DNA
<213>  Homosapiens

<400>  1819
ggtttcatat gaactctccc gccacccggg aacagtggct gccaccgttt gtgttttccc     60

gagtttgaat tcttgcaggt gaccaagatg gagttttctg gaagaaagtg gaggaagctg    120

aggttggcag gtgaccagag gaatgcttcc taccctcatt gccttcagtt ttacttgcag    180

ccaccttctg aaaacatatc tttaatagaa tttgaaaact tggctattga tagagttaaa    240

ttgttaaaat cagttgaaaa tcttggagtg agctatgtga aaggaactga acaataccag    300

agtaagttgg agagtgagct tcggaagctc aagttttcct acagagaaaa cttagaagat    360

gaatatgaac cacgaagaag agatcatatt tctcatttta ttttgcggct tgcttattgc    420

cagtctgaag aacttagacg ctggttcatt caacaagaaa tggatctcct tcgatttaga    480

tttagtattt tacccaagga taaaattcag gatttcttaa aggatagcca attgcagttt    540

gaggctataa gtgatgaaga gaagactctt cgagaacagg agattgttgc ctcatcacca    600

agtttaagtg gacttaagtt ggggttcgag tccatttata agatcccttt tgctgatgct    660

ctggatttgt ttcgaggaag gaaagtctat ttggaagatg gctttgctta cgtaccactt    720

aaggacattg tggcaatcat cctgaatgaa tttagagcca aactgtccaa ggctttggca    780

ttaacagcca ggtccttgcc tgctgtgcag tctgatgaaa gacttcagcc tctgctcaat    840

cacctcagtc attcctacac tggccaagat tacagtaccc agggaaatgt tgggaagatt    900

tctttagatc agattgattt gctttctacc aaatccttcc caccttgcat gcgtcagtta    960

cataaagcct tgcgggaaaa tcaccatctt cgtcatggag gccgaatgca gtatggccta   1020

tttctgaagg gcattggttt aactttggaa caggcattgc agttctggaa gcaagaattt   1080

atcaaaggaa agatggatcc agacaagttt gataaaggtt actcttacaa catccgtcac   1140

agctttggaa aggaaggcaa gaggacagac tatacacctt tcagttgcct gaagattatt   1200

ctgtccaatc caccaagcca aggggattat catgggtgcc cattccgtca cagtgatcca   1260

gagctgctga agcaaaagtt gcagtcatac aagatctctc ctggagggat aagccagatt   1320

ttggatttag taaaggggac acattaccag gtagcctgtc aaaaatactt tgagatgata   1380

cacaatgtgg atgattgtgg cttttctttg aatcatccta atcagttctt ttgtgagagc   1440

caacgtattc taaatggtgg taaagacata aagaaggaac ctatccaacc agaaactcct   1500

caacccaaac caagtgtcca gaaaaccaag gatgcatcat ctgctctggc ctctttaaat   1560

tcctctctgg aaatggatat ggaaggacta gaagattact ttagtgaaga ttcttaggca   1620

gttttataac cctttttcct caatagcctg tttcctgttt ttaagatttt gcctttgttg   1680

ttgaaaaagg gtttcactct gtcaccaagg cttagtgcag tgacacaatt acagctgatt   1740

gcagccttga ccttcccagc tcaagtgatc ctcctacctc agcctcccaa gtagttagga   1800

ccacaggtgt gcacctcata tccagataat ttttttcaat ttttttttgt agaggtgggg   1860

ggtctcccta tgttgcccag gcagatctca gactcctggg ctcaagcgat cctcacacct   1920

cagcgtccca gagtgctggg attacggttg tgagccactg tgcctggcct tttttttttt   1980

ttttaacctt tttgtttaac ttctctcttc actgcatccc aatccatcta caggcatgca   2040

cacttattag gaaaggaggt ttgaggtaac aacagagact ttcactatat tttgctttga   2100

cagaaggaaa gaggaggagt ttctattaaa atctgtcact tgagtgatgt catttaagtc   2160

ctattttagg agataaaaac agctttgggg actggttaaa gtcccccaga aactacaata   2220

aagaacaact tttgttttaa ctcttaatca ctttgtaatt ttgactcaat ccttttctgg   2280

accatttttg ttaataaata tcaaagtgta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2340

aaaaaaaaaa aaa                                                      2353


<210>  1820
<211>  509
<212>  PRT
<213>  Homosapiens

<400>  1820

Met Glu Phe Ser Gly Arg Lys Trp Arg Lys Leu Arg Leu Ala Gly Asp 
1               5                   10                  15      


Gln Arg Asn Ala Ser Tyr Pro His Cys Leu Gln Phe Tyr Leu Gln Pro 
            20                  25                  30          


Pro Ser Glu Asn Ile Ser Leu Ile Glu Phe Glu Asn Leu Ala Ile Asp 
        35                  40                  45              


Arg Val Lys Leu Leu Lys Ser Val Glu Asn Leu Gly Val Ser Tyr Val 
    50                  55                  60                  


Lys Gly Thr Glu Gln Tyr Gln Ser Lys Leu Glu Ser Glu Leu Arg Lys 
65                  70                  75                  80  


Leu Lys Phe Ser Tyr Arg Glu Asn Leu Glu Asp Glu Tyr Glu Pro Arg 
                85                  90                  95      


Arg Arg Asp His Ile Ser His Phe Ile Leu Arg Leu Ala Tyr Cys Gln 
            100                 105                 110         


Ser Glu Glu Leu Arg Arg Trp Phe Ile Gln Gln Glu Met Asp Leu Leu 
        115                 120                 125             


Arg Phe Arg Phe Ser Ile Leu Pro Lys Asp Lys Ile Gln Asp Phe Leu 
    130                 135                 140                 


Lys Asp Ser Gln Leu Gln Phe Glu Ala Ile Ser Asp Glu Glu Lys Thr 
145                 150                 155                 160 


Leu Arg Glu Gln Glu Ile Val Ala Ser Ser Pro Ser Leu Ser Gly Leu 
                165                 170                 175     


Lys Leu Gly Phe Glu Ser Ile Tyr Lys Ile Pro Phe Ala Asp Ala Leu 
            180                 185                 190         


Asp Leu Phe Arg Gly Arg Lys Val Tyr Leu Glu Asp Gly Phe Ala Tyr 
        195                 200                 205             


Val Pro Leu Lys Asp Ile Val Ala Ile Ile Leu Asn Glu Phe Arg Ala 
    210                 215                 220                 


Lys Leu Ser Lys Ala Leu Ala Leu Thr Ala Arg Ser Leu Pro Ala Val 
225                 230                 235                 240 


Gln Ser Asp Glu Arg Leu Gln Pro Leu Leu Asn His Leu Ser His Ser 
                245                 250                 255     


Tyr Thr Gly Gln Asp Tyr Ser Thr Gln Gly Asn Val Gly Lys Ile Ser 
            260                 265                 270         


Leu Asp Gln Ile Asp Leu Leu Ser Thr Lys Ser Phe Pro Pro Cys Met 
        275                 280                 285             


Arg Gln Leu His Lys Ala Leu Arg Glu Asn His His Leu Arg His Gly 
    290                 295                 300                 


Gly Arg Met Gln Tyr Gly Leu Phe Leu Lys Gly Ile Gly Leu Thr Leu 
305                 310                 315                 320 


Glu Gln Ala Leu Gln Phe Trp Lys Gln Glu Phe Ile Lys Gly Lys Met 
                325                 330                 335     


Asp Pro Asp Lys Phe Asp Lys Gly Tyr Ser Tyr Asn Ile Arg His Ser 
            340                 345                 350         


Phe Gly Lys Glu Gly Lys Arg Thr Asp Tyr Thr Pro Phe Ser Cys Leu 
        355                 360                 365             


Lys Ile Ile Leu Ser Asn Pro Pro Ser Gln Gly Asp Tyr His Gly Cys 
    370                 375                 380                 


Pro Phe Arg His Ser Asp Pro Glu Leu Leu Lys Gln Lys Leu Gln Ser 
385                 390                 395                 400 


Tyr Lys Ile Ser Pro Gly Gly Ile Ser Gln Ile Leu Asp Leu Val Lys 
                405                 410                 415     


Gly Thr His Tyr Gln Val Ala Cys Gln Lys Tyr Phe Glu Met Ile His 
            420                 425                 430         


Asn Val Asp Asp Cys Gly Phe Ser Leu Asn His Pro Asn Gln Phe Phe 
        435                 440                 445             


Cys Glu Ser Gln Arg Ile Leu Asn Gly Gly Lys Asp Ile Lys Lys Glu 
    450                 455                 460                 


Pro Ile Gln Pro Glu Thr Pro Gln Pro Lys Pro Ser Val Gln Lys Thr 
465                 470                 475                 480 


Lys Asp Ala Ser Ser Ala Leu Ala Ser Leu Asn Ser Ser Leu Glu Met 
                485                 490                 495     


Asp Met Glu Gly Leu Glu Asp Tyr Phe Ser Glu Asp Ser 
            500                 505                 


<210>  1821
<211>  1947
<212>  DNA
<213>  Homosapiens

<400>  1821
gtggtttcta acgctgaact taaaaagtgt tgagatgaat aatgaagagg accttctgca     60

ggaggactca acaagagatg aaggcaatga gactgaagcc aacagcatga acacattaag    120

aaggacaagg aagaaagtca ctaaaccata tgtttgttca actgaagtgg gagaaacgga    180

tatgtccaat tcaaatgatt gcatgaggga cagcagtcaa attttgaccc cacctcaact    240

ctcttctaga atgaaacaca ttagacaagc catggccaaa aatcgcctcc agtttgtacg    300

atttgaagca acagacctcc acggcgtgtc caggtctaag actatccctg cacacttttt    360

tcaagagaaa gtgagccatg gtgtttgcat gccccgaggt tatcttgaag tgataccaaa    420

tccaaaggac aatgaaatga ataacataag agccacatgt tttaatagcg acatagtcct    480

aatgccagag ttatcaacct ttagagtttt gccatgggct gacagaactg caagagtgat    540

atgtgatacc ttcactgtga ctggtgagcc tcttttgact tccccaaggt acattgcaaa    600

gaggcagctg agccatctgc aggcctctgg cttttccctg ctttctgctt tcatctatga    660

tttttgcatt tttggtgtgc ccgaaatttt aaattcaaag attatatctt ttcctgcttt    720

aacattttta aataaccatg atcagccctt catgcaggaa cttgttgatg gcttgtatca    780

cactggagcc aatgtcgaga gtttttcctc ctctaccagg cctggtcaga tggaaatctc    840

tttcctgcct gaatttggca ttagctcagc tgataatgca tttaccctca gaacaggtgt    900

caaagaagtg gcaaggaaat ataattacat tgccagcttc ttcattgaga ctggattttg    960

tgattcaggg attttgtctc atagtctctg ggatgtcgat aggaagaaaa acatgttctg   1020

cagcacttct ggaactgagc agctcacgat cactgggaaa aaatggttgg caggactctt   1080

gaagcactct gctgcgctca gctgcctgat ggcgccttct gttagctgcc gaaagcgtta   1140

ttccaaggac aggaaagacc tgaagaagag tgtgcctaca acatggggat acaatgacaa   1200

cagctgtata tttaatatca aatgtcatgg agagaaaggc acccggatag aaaataaact   1260

aggctcagca acagcaaacc cttacttggt gctggctgca actgttgctg ccggcttaga   1320

tggacttcat agcagtaatg aggtcttggc tggtccagat gagagcacag acttttacca   1380

agtggaacct tctgagatcc ctttaaaact agaagatgcc cttgtggcac tggaagaaga   1440

tcaatgccag agacaggctc taggagaaac ctttattcga tattttgttg ccatgaagaa   1500

atatgagttg gagaatgaag aaatagctgc agagagaaat aaattcttag agtattttat   1560

ttagaataga gctcacaact actcctttag acatgtaatt gttacttaaa gctaatctac   1620

caaaacaaaa agactgaact tttgtaatta acaacagcaa caataacaag attacgaatg   1680

cttttgactt ttttttttgt ccatggaata tttgacagat gaagtaggac tgctgagaag   1740

attctgataa cagaaacaaa caacaaagtt gtggtgaagc tataatatgc aaacttacca   1800

gatcttgtca gtcatttcct atgtgtatgt tgacctggat aagaatatcc aattttgggt   1860

ggcaataaat atattcgcac attaagaaaa aaaagactta agcattagaa agcaaaattt   1920

aaatgactaa aaaaaaaaaa aaaaaaa                                       1947


<210>  1822
<211>  509
<212>  PRT
<213>  Homosapiens

<400>  1822

Met Asn Asn Glu Glu Asp Leu Leu Gln Glu Asp Ser Thr Arg Asp Glu 
1               5                   10                  15      


Gly Asn Glu Thr Glu Ala Asn Ser Met Asn Thr Leu Arg Arg Thr Arg 
            20                  25                  30          


Lys Lys Val Thr Lys Pro Tyr Val Cys Ser Thr Glu Val Gly Glu Thr 
        35                  40                  45              


Asp Met Ser Asn Ser Asn Asp Cys Met Arg Asp Ser Ser Gln Ile Leu 
    50                  55                  60                  


Thr Pro Pro Gln Leu Ser Ser Arg Met Lys His Ile Arg Gln Ala Met 
65                  70                  75                  80  


Ala Lys Asn Arg Leu Gln Phe Val Arg Phe Glu Ala Thr Asp Leu His 
                85                  90                  95      


Gly Val Ser Arg Ser Lys Thr Ile Pro Ala His Phe Phe Gln Glu Lys 
            100                 105                 110         


Val Ser His Gly Val Cys Met Pro Arg Gly Tyr Leu Glu Val Ile Pro 
        115                 120                 125             


Asn Pro Lys Asp Asn Glu Met Asn Asn Ile Arg Ala Thr Cys Phe Asn 
    130                 135                 140                 


Ser Asp Ile Val Leu Met Pro Glu Leu Ser Thr Phe Arg Val Leu Pro 
145                 150                 155                 160 


Trp Ala Asp Arg Thr Ala Arg Val Ile Cys Asp Thr Phe Thr Val Thr 
                165                 170                 175     


Gly Glu Pro Leu Leu Thr Ser Pro Arg Tyr Ile Ala Lys Arg Gln Leu 
            180                 185                 190         


Ser His Leu Gln Ala Ser Gly Phe Ser Leu Leu Ser Ala Phe Ile Tyr 
        195                 200                 205             


Asp Phe Cys Ile Phe Gly Val Pro Glu Ile Leu Asn Ser Lys Ile Ile 
    210                 215                 220                 


Ser Phe Pro Ala Leu Thr Phe Leu Asn Asn His Asp Gln Pro Phe Met 
225                 230                 235                 240 


Gln Glu Leu Val Asp Gly Leu Tyr His Thr Gly Ala Asn Val Glu Ser 
                245                 250                 255     


Phe Ser Ser Ser Thr Arg Pro Gly Gln Met Glu Ile Ser Phe Leu Pro 
            260                 265                 270         


Glu Phe Gly Ile Ser Ser Ala Asp Asn Ala Phe Thr Leu Arg Thr Gly 
        275                 280                 285             


Val Lys Glu Val Ala Arg Lys Tyr Asn Tyr Ile Ala Ser Phe Phe Ile 
    290                 295                 300                 


Glu Thr Gly Phe Cys Asp Ser Gly Ile Leu Ser His Ser Leu Trp Asp 
305                 310                 315                 320 


Val Asp Arg Lys Lys Asn Met Phe Cys Ser Thr Ser Gly Thr Glu Gln 
                325                 330                 335     


Leu Thr Ile Thr Gly Lys Lys Trp Leu Ala Gly Leu Leu Lys His Ser 
            340                 345                 350         


Ala Ala Leu Ser Cys Leu Met Ala Pro Ser Val Ser Cys Arg Lys Arg 
        355                 360                 365             


Tyr Ser Lys Asp Arg Lys Asp Leu Lys Lys Ser Val Pro Thr Thr Trp 
    370                 375                 380                 


Gly Tyr Asn Asp Asn Ser Cys Ile Phe Asn Ile Lys Cys His Gly Glu 
385                 390                 395                 400 


Lys Gly Thr Arg Ile Glu Asn Lys Leu Gly Ser Ala Thr Ala Asn Pro 
                405                 410                 415     


Tyr Leu Val Leu Ala Ala Thr Val Ala Ala Gly Leu Asp Gly Leu His 
            420                 425                 430         


Ser Ser Asn Glu Val Leu Ala Gly Pro Asp Glu Ser Thr Asp Phe Tyr 
        435                 440                 445             


Gln Val Glu Pro Ser Glu Ile Pro Leu Lys Leu Glu Asp Ala Leu Val 
    450                 455                 460                 


Ala Leu Glu Glu Asp Gln Cys Gln Arg Gln Ala Leu Gly Glu Thr Phe 
465                 470                 475                 480 


Ile Arg Tyr Phe Val Ala Met Lys Lys Tyr Glu Leu Glu Asn Glu Glu 
                485                 490                 495     


Ile Ala Ala Glu Arg Asn Lys Phe Leu Glu Tyr Phe Ile 
            500                 505                 


<210>  1823
<211>  375
<212>  DNA
<213>  Homosapiens

<400>  1823
atgggtttca gagacctgaa aagccccact ggcctccagg tgcacaatgg ttacctggct     60

gaccagagct gcaacaaggg gtatgtgcca tcacaagcag acgtggcagt aattgaagca    120

gtctccagtc cattgtccgg taatttgtgt catgctctac attggtataa ttacatcaag    180

tcttacgaaa aggaaaaagc cagcctagca ggaatgaaga aagctttggg caagtatgga    240

cctgctaatg tggaagatag tagaggaagt ggagctacag atagtgaaga tgacaatgac    300

atttatctat ttggatttga taagggggag gaaagcaaag aatcaaaaag gcaaagggaa    360

gaataccctg catag                                                     375


<210>  1824
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  1824

Met Gly Phe Arg Asp Leu Lys Ser Pro Thr Gly Leu Gln Val His Asn 
1               5                   10                  15      


Gly Tyr Leu Ala Asp Gln Ser Cys Asn Lys Gly Tyr Val Pro Ser Gln 
            20                  25                  30          


Ala Asp Val Ala Val Ile Glu Ala Val Ser Ser Pro Leu Ser Gly Asn 
        35                  40                  45              


Leu Cys His Ala Leu His Trp Tyr Asn Tyr Ile Lys Ser Tyr Glu Lys 
    50                  55                  60                  


Glu Lys Ala Ser Leu Ala Gly Met Lys Lys Ala Leu Gly Lys Tyr Gly 
65                  70                  75                  80  


Pro Ala Asn Val Glu Asp Ser Arg Gly Ser Gly Ala Thr Asp Ser Glu 
                85                  90                  95      


Asp Asp Asn Asp Ile Tyr Leu Phe Gly Phe Asp Lys Gly Glu Glu Ser 
            100                 105                 110         


Lys Glu Ser Lys Arg Gln Arg Glu Glu Tyr Pro Ala 
        115                 120                 


<210>  1825
<211>  5099
<212>  DNA
<213>  Homosapiens

<400>  1825
gatgaccgtg gttaaggcag tagaaagcag gctcgacact gagacgcggt tccagcccta     60

gaaggattgc attttacgat tcaggcaaac ttcgagtctc ctcatgtgac atgtgtgcac    120

tcctggaccg ttttaattat gagaaacgtg gtttgcagca tgattccttc cagtcgataa    180

atcggaatct ctctcgctcc caccccttct taacttcagg cttcctgcat cccggagcac    240

tcccggcagc cccttccctc ccccgccccg gggatgctcc gactcggcgc ttagccattc    300

atcaaccggt tcacaccggc ggcggccgcc gcggagtgac gtccggaggg ggcgggcctc    360

cgcccccgcc tgtcggctcc tggcccgcgg ttccaggccg cgattggtgg ctggagggtt    420

gcacgtcgcg ccggctataa aggggagggc ttgtgacgca agggcgcctc ggcgcgtgta    480

ttggctcctt cggctgcggg ccggctcggc tacgcgctct gctccgagcc gctcactgca    540

tggtagagtc tggtgccccc gccgccgcct gcatcgccgc caccgccgct ccgccacgac    600

caccgccgcc tcctgccctg cagccaccgc caccgcctgt gtcgccgccg cctcgggacc    660

ggctgtatga ttaggccaca atcttcaatg agtaaacata ttcctcaatt ctgtggtgtt    720

cttggtcaca catttatgga gtttctgaag ggcagtggag attactgcca ggcacagcac    780

gacctctatg cagacaagtg aactgtagaa actgattact gctccaccaa gaagccccca    840

taagagtggt tatcctggac acagaagtgt tgaattgaaa tccacagagc attttacaag    900

agttctgacc tggatggggt aaacctcagt gcacttcttt tctgttggcc tcagtattac    960

tggattgaag aattgctgct tcttgttagg aggttcattt cacttatcat tacttacaac   1020

ttcatactca aagcactgag aatttcaagt ggagtatatt gaagtagact tcagtttctt   1080

tgcatcattt ctgtattcaa tttttttaat tatttcataa ccctattgag tgttttttaa   1140

ctaaattaac atggctcgaa tgaaccgccc agctcctgtg gaagtcacat acaagaacat   1200

gagatttctt attacacaca atccaaccaa tgcgacctta aacaaattta tagaggaact   1260

taagaagtat ggagttacca caatagtaag agtatgtgaa gcaacttatg acactactct   1320

tgtggagaaa gaaggtatcc atgttcttga ttggcctttt gatgatggtg caccaccatc   1380

caaccagatt gttgatgact ggttaagtct tgtgaaaatt aagtttcgtg aagaacctgg   1440

ttgttgtatt gctgttcatt gcgttgcagg ccttgggaga gctccagtac ttgttgccct   1500

agcattaatt gaaggtggaa tgaaatacga agatgcagta caattcataa gacaaaagcg   1560

gcgtggagct tttaacagca agcaacttct gtatttggag aagtatcgtc ctaaaatgcg   1620

gctgcgtttc aaagattcca acggtcatag aaacaactgt tgcattcaat aaaattgggg   1680

tgcctaatgc tactggaagt ggaacttgag atagggccta atttgttata catattagcc   1740

aacatgttgg cttagtaagt ctaatgaagc ttccatagga gtattgaaag gcagttttac   1800

caggcctcaa gctagacaga tttggcaacc tctgtatttg ggttacagtc aacctatttg   1860

gatacttggc aaaagattct tgctgtcagc atataaaatg tgcttgtcat ttgtatcaat   1920

tgacctttcc ccaaatcatg cagtattgag ttatgacttg ttaaatctat tcccatgcca   1980

gaatcttatc aatacataag aaatttagga agattaggtg ccaaaatacc cagcacaata   2040

cttgtatatt tttagtacca tacagaagta aaatcccagg aactatgaac actagacctt   2100

atgtggttta ttccttcaat catttcaaac attgaaagta gggcctacat ggttatttgc   2160

ctgctcactt tatgtttaca tctcccacat tcataccaat atacgtcagg tttgcttaac   2220

cattgatttt tttttttttt taccaagtct tacagtgatt attttacgtg tttccatgta   2280

tctcactttg tgctgtatta aaaaaacctc cattttgaaa atctacgttg tacagaagca   2340

catgtcttta atgtcttcag acaaaaaagc cttacattaa tttaatgttt gcactctgag   2400

gtgcaactta acagggaggg cctgagaaaa gaatgggagg gggctattaa ttatttttag   2460

caaaatgttg cctttgtctt gtgcaaacat gtagaatatg ctctttaatt tagtaaaata   2520

tttttttaaa aggtagagat gctttgttat tgtaatcata aacttcctga aattcttgta   2580

atttttttcc catacttatc agaagtgtgt ttaccaactt atttttgttt gaaagtgtga   2640

tttttttttt ccttcccaac ctctcttgca aaaaaagaaa tgggtttctg ctaatgaatt   2700

gagcagacat ctaatatttt atatgccttt tgagctgtgt aacttaatat ttggatactt   2760

gacaatttgt tttattatgt aattgataaa atggtgatgt gtattaatgt tagttcaacc   2820

atatatttat actgtctggg gatgtgtggt tatagttctg tgggagaaat aattttgtca   2880

gtgttcacca gcttgtaaaa acttagtgcg agagctgaaa catctaaata aataatgaca   2940

tgcatttatc atcattgaga ttggtttgct taaaattaac ttattttgta gaagacaaaa   3000

tgaattgcac ttcacttaat gtgtgtcctc atctttttac aaataaatga aggattataa   3060

atgatgtcag cattttagta aacttttaga caaaatttgt tagggtcatt catgaaaact   3120

ttaatactaa aagcactttc cattatatac tttttaaagg tctagataat tttgaaccaa   3180

tttattattg tgtactgagg agaaataatg tatagtagag gacagccttg gtttgtaaag   3240

ctcagttcca ctagttcatg gttttgtgca acttctgagc ctcagttttc tcctttgcaa   3300

attaataatt acataccttt atagattttg aaattaattt aaatattagt atttggtaca   3360

tgaaggctta atgttaagtt tcctttaatg atccacaata atccctttga tcacgttaat   3420

ctaaatctag atgtctttgt ctaatttttt ttgaatagca gttataaatg taaaggactc   3480

aaagtttaag taaaaagtga tactccacct tgtgtttcaa agaatttagt tccacctctt   3540

cataccagtt taacacttaa tatatttcat tggattttag acagggcaaa aggaagaaca   3600

ggggcctctg gaggcccttg gttatttaaa tcttggatta tttgtgatag taatcacaaa   3660

tttttggcta atttttaacc tgaggttttg tttttttttt aaaggaaatg cagcctagtc   3720

ttgagaacat aattttatat aatcaattac taaatgttaa actattacca cacagcccat   3780

aaaacagcat ttgcgtttat tgagagagag gatgtgccat catgattaat gaaaactatc   3840

ttttgagttt gaaaagaaat taatttgcag tgtttggatt gtatatatgg tgctaaaaat   3900

aaattaattt actttataaa ccttatctgt acattatacg atgtgatgaa atttgctttt   3960

tatccaaata ttttgtatct tgtaaatatg gctaattata ggaatgccta taatacatct   4020

tagattcctt atatctaata agagttcaaa gagttatgag ttgaagtctt gaatgcagga   4080

aactatctga tagtgttcta aaatttggtt acttgggttt ggataccctt agtgggatga   4140

tgtaaataga ggctagctac ctaggcttgt ctatagcaac cataatgttg atgtaagtaa   4200

tgcggttact gaatcataag aaaatgccat ctctttttag ttgaaggaaa actctggaag   4260

taggtgccat tggtcattct gcagtgcact gcaaccattg tttcccctag tgccctcttt   4320

tccctagggc attgctctcc tattcccacg ccttaacaca gctctatacc tagaagcagc   4380

cagcccaggc atgcagtcac atttaatcac atcccccttc tagagtgctt caaaatgatg   4440

tagtccctca acttggctaa agaatctcaa tctcttgaaa tttatttttt taatgtcata   4500

ttcatctggt aaatatctac tgtttgccag gcatttaaga atatggcaaa gaacataaaa   4560

gatggtgtca ccagattttg gtcaccaatg agtacccgac ccgttgccat gattaagaga   4620

gaatgctttc tattggagtt tcaggaaata taatttgaga atactttaaa gggaagtgga   4680

agtataagtg aatgatattt ttcttttaca tgtaaacaat gaagttattt caaagttaag   4740

ttttaaacaa aatacatgaa gtagtgtctg ccatacatgt taatattcta cattcttgct   4800

tccttaaatt aatatgtttg tgtgtatata tgtgcctcac acctgaattg aaaattaaag   4860

actggtttaa aagtggttta aaagtgacat ttaatgtttc tccattacgt ttggggtaac   4920

cagcctaagt ggaatcttgg aaggaaagta agggaaaaac ttgtatttgc cttcaatgaa   4980

ttaaaccagt gatatgtgtt aacgtatgaa tgaaaggatt gatggtgatt ttataattat   5040

atatattgcc gcagtaacca gttaataaat tgatagctac caaaaaaaaa aaaaaaaaa    5099


<210>  1826
<211>  173
<212>  PRT
<213>  Homosapiens

<400>  1826

Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Thr Tyr Lys Asn 
1               5                   10                  15      


Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Asn Lys 
            20                  25                  30          


Phe Ile Glu Glu Leu Lys Lys Tyr Gly Val Thr Thr Ile Val Arg Val 
        35                  40                  45              


Cys Glu Ala Thr Tyr Asp Thr Thr Leu Val Glu Lys Glu Gly Ile His 
    50                  55                  60                  


Val Leu Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Ser Asn Gln Ile 
65                  70                  75                  80  


Val Asp Asp Trp Leu Ser Leu Val Lys Ile Lys Phe Arg Glu Glu Pro 
                85                  90                  95      


Gly Cys Cys Ile Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro 
            100                 105                 110         


Val Leu Val Ala Leu Ala Leu Ile Glu Gly Gly Met Lys Tyr Glu Asp 
        115                 120                 125             


Ala Val Gln Phe Ile Arg Gln Lys Arg Arg Gly Ala Phe Asn Ser Lys 
    130                 135                 140                 


Gln Leu Leu Tyr Leu Glu Lys Tyr Arg Pro Lys Met Arg Leu Arg Phe 
145                 150                 155                 160 


Lys Asp Ser Asn Gly His Arg Asn Asn Cys Cys Ile Gln 
                165                 170             


<210>  1827
<211>  6948
<212>  DNA
<213>  Homosapiens

<400>  1827
ggggctgaaa gacacacaga agtcttcatg gatatagttg atacatttaa tcatttaatt     60

cctactgaac acttagatga tgccctattt ctaggatcca acctggagaa tgaagtctgt    120

gaggatttta gtgcaagtca aaatgtctta gaggactcgc tgaagaacat gctcagcgat    180

aaggatccta tgctaggatc tgcaagtaac cagttctgtt tgcctgtttt ggatagcaat    240

gatcccaatt tccagatgcc ttgttcaaca gttgttggtc ttgacgatat tatggatgaa    300

ggagttgtta aagaaagtgg caatgatacc attgatgaag aagaactgat tttacctaac    360

aggaacttaa gggacaaggt agaagaaaat tcagtgagat ctccaagaaa atcacctcgt    420

ttaatggcac aagaacaagt aagaagtttg cgacagagca ctattgccaa gcgttcaaat    480

gcagcaccat taagtaacac aaaaaaagca tctgggaaga ctgtatctac tgctaaagca    540

ggagtgaaac aaccagaaag gagtcaggtt aaagaagaag tatgtatgtc actgaaacct    600

gagtaccata aggagaatag aaggtgcagc cgaaatagcg gacaaattga agtggtacct    660

gaagtatcag tgtcttcaag tcattcttca gtgtcatctt gtcttgaaat gaaggatgaa    720

gatggattag attctaagca taagtgtaat aatccgggag aaatagatgt gccatctcat    780

gaattaaatt gttcacttct ttcagagact tgtgttacta ttggagaaaa gaaaaatgaa    840

gctttgatgg aatgtaaagc caagcctgtt ggtagtccat tgtttaagtt ttcagataaa    900

gaagaacatg aacaaaatga ttccatttca ggtaaaacgg gtgagactgt tgttgaagaa    960

atgatagcaa caagaaaagt tgaacaagat tcaaaggaga cagtaaaatt atcccatgaa   1020

gatgaccata ttcttgagga cgctggatct tctgatattt ctagtgatgc tgcttgtaca   1080

aatccaaata agacagaaaa cagccttgta ggtttgccta gttgtgtaga tgaagtgact   1140

gaatgtaatt tggaattgaa ggataccatg ggtattgctg ataaaactga gaacaccctt   1200

gaaagaaata aaattgaacc gttgggttat tgtgaagatg cggagtctaa taggcagttg   1260

gagagcactg agtttaataa atcaaactta gaggtggttg atactagtac ttttggaccg   1320

gaaagtaata tcttggaaaa tgctatttgt gatgtgcctg accaaaattc aaaacagttg   1380

aatgctatag aaagtactaa aatagagtcc catgaaacag caaaccttca ggatgacaga   1440

aacagccagt caagtagcgt ttcttactta gagtcaaaaa gtgtaaaatc caaacataca   1500

aaacctgtaa ttcattctaa gcaaaacatg accacagatg ctccgaagaa aattgttgca   1560

gcaaagtatg aagtaataca tagcaaaact aaagttaatg tcaaaagtgt gaaacgaaat   1620

actgatgtac cagaatctca gcaaaatttt cataggccag tcaaagtcag aaaaaaacaa   1680

attgataagg agccaaagat tcagagttgc aattctgggg ttaaatctgt gaaaaaccaa   1740

gctcattctg tactgaaaaa aacattacag gatcaaactt tagtacaaat tttcaagccc   1800

ttaactcatt ctttgagtga taagtcacac gctcatcctg gttgcttgaa agaacctcat   1860

catcctgcac aaactggaca tgtatcacat tctagccaga aacagtgtca taagcctcag   1920

caacaggccc cagcaatgaa aaccaatagt cacgtgaagg aagagcttga acacccaggc   1980

gttgagcatt ttaaggaaga ggataaactg aaactgaaaa aacctgagaa gaacctacaa   2040

ccccgccaaa gaagaagcag caaaagtttt tctttagatg agccaccatt gttcattcca   2100

gataacatag ctaccataag aagagaaggc tctgatcata gctcctcatt tgaaagcaaa   2160

tatatgtgga ctcccagcaa gcagtgtggg ttttgcaaaa aaccacatgg caacaggttt   2220

atggttggct gtgggagatg tgatgactgg tttcatggtg attgtgttgg gttaagtctt   2280

tctcaagcac agcagatggg cgaggaagac aaagaatatg tctgtgtaaa atgttgtgct   2340

gaagaagaca aaaagactga aatactagat ccagatactt tggaaaacca agctacagtt   2400

gaattccata gtggagataa aacaatggag tgtgaaaagc ttggattatc aaaacacaca   2460

acaaatgata gaaccaaata tatagatgat acagtgaagc acaaggtcaa aattttaaaa   2520

cgggagtctg gtgaaggcag aaattcatca gactgtagag ataatgaaat taaaaaatgg   2580

cagctagctc ctcttcgtaa gatgggacaa ccagttttac ctcggagatc ctcagaagaa   2640

aaaagtgaaa aaataccgaa agagtctaca actgttactt gcacaggaga aaaagcttca   2700

aaaccaggta ctcatgagaa gcaagagatg aaaaagaaga aagttgaaaa aggagtgctt   2760

aatgtacatc ctgctgcttc tgcttccaag ccttctgcag atcagatcag gcaaagtgtc   2820

agacattctc tcaaagacat tcttatgaag agacttacag actcaaattt gaaggtacca   2880

gaggaaaagg cagcaaaagt tgccacaaaa attgagaaag agcttttctc tttttttcgg   2940

gacacagatg ctaaatataa gaacaaatat agaagtttga tgtttaattt gaaagatcct   3000

aaaaacaata tattatttaa aaaagtactg aaaggagaag taactcctga tcatcttatc   3060

agaatgagtc cagaagaact agcttctaaa gagttagctg cttggagacg aagagaaaac   3120

agacatacca tagaaatgat tgagaaagag cagagagaag tggaacgacg gccaatcacc   3180

aaaataactc ataaaggtga aatagaaatt gagagtgatg ccccaatgaa agaacaggaa   3240

gcagccatgg agattcagga accagccgcc aataagtcat tggagaagcc agaaggatct   3300

gaaaaacaaa aagaggaggt tgactctatg tctaaagata ccactagtca acacagacag   3360

catctttttg atctcaactg caaaatctgc ataggtcgaa tggcaccacc tgtagatgat   3420

ctttctccaa aaaaagtaaa agttgttgta ggagtagctc gcaaacattc agacaatgaa   3480

gcagaaagta tagcagatgc attatcttca acctcaaata ttttggcttc tgaattcttt   3540

gaggaggaga aacaggagtc tccaaagtca acgttctctc ctgctccacg tccagagatg   3600

cctggaactg ttgaagttga gtctaccttt ctggctcgat tgaacttcat ctggaaaggt   3660

tttatcaaca tgccttctgt ggcaaaattt gttaccaaag cctatccagt atctggctcc   3720

ccagaatacc tgacagagga cctaccagat agtattcaag taggtggcag gatatcacct   3780

cagacagttt gggattatgt ggaaaaaata aaagcatcag gaaccaagga aatttgtgtg   3840

gttcgcttca caccagtaac tgaagaagat caaatttctt atactttgct ctttgcatac   3900

ttcagtagca gaaagcgcta tggagtagct gctaacaaca tgaagcaggt taaagatatg   3960

taccttattc ctttgggtgc cacagataaa attccacacc ctcttgtgcc ttttgatgga   4020

cctgggcttg aactgcatag acctaatcta ttgttgggct taattattcg tcagaaactg   4080

aagcgacagc acagtgcctg tgctagtact agtcatatag ctgagactcc tgaaagtgca   4140

ccaccaatag cattgccacc tgataaaaaa agtaaaatag aagtttctac agaagaagca   4200

ccagaggaag aaaatgactt ttttaattct tttacaactg tattacacaa gcagagaaat   4260

aaacctcagc agaatcttca ggaagacctt ccaacagcag ttgaaccttt aatggaagtc   4320

accaaacagg agccaccaaa acctttaaga tttcttcctg gcgtgttgat tggctgggag   4380

aatcaaccta ctactctgga attagcaaat aaacctcttc ctgtggatga tatacttcaa   4440

agccttttgg gcaccactgg tcaagtatat gaccaggccc agtcagtgat ggaacaaaac   4500

actgttaaag aaattccatt tttaaatgag cagaccaact caaaaataga gaaaacagat   4560

aatgtggaag taactgatgg tgaaaacaag gagataaaag ttaaagtaga taatatttca   4620

gaatctacag ataagtcagc agaaatagaa acatcagtag tagggtcctc ttccatttct   4680

gcagggtctt tgacgagtct tagtctcaga ggtaagccac cagatgtttc tacagaagca   4740

tttttaacaa atttatcaat tcagtcaaaa caagaggaaa ctgtggagag taaagagaaa   4800

acattaaaaa gacagcttca ggaagatcaa gagaataatt tgcaagataa ccagacttca   4860

aatagttctc catgcagatc taatgtagga aaaggaaaca tagatggtaa tgtgagctgt   4920

agtgaaaacc ttgttgctaa tacagcgagg tctccacagt ttatcaacct gaaaagggat   4980

cctaggcaag cagcaggacg aagtcagcct gtaactactt cagaaagcaa agatggagat   5040

agttgccgga atggagaaaa acacatgctg cctggcctgt cacacaacaa ggagcactta   5100

acagaacaaa tcaatgtaga ggaaaagttg tgttctgcag agaaaaactc gtgtgttcag   5160

cagagtgaca atttaaaagt tgcacaaaac tcaccatcag tagaaaacat acagacttct   5220

caagcagaac aagcaaaacc cttacaggag gatattttaa tgcaaaatat tgaaactgtg   5280

cacccatttc gaagaggatc agcagtagcg acatctcatt ttgaagttgg aaacacatgt   5340

ccatcagaat ttccttctaa aagcatcacc tttacttcca gaagcaccag ccccagaaca   5400

agtacaaact tttcacccat gaggccacag cagcccaacc ttcagcatct caagtctagc   5460

ccacctggat ttccatttcc agggcctcct aattttcccc cacaaagcat gtttggattt   5520

ccaccacatt tgccacctcc attacttccc cctccaggct ttggctttgc tcaaaatccc   5580

atggttccct ggccacctgt tgttcatctc ccaggtcagc cacagcgtat gatgggtcct   5640

ctctcacaag catcaaggta tataggcccg cagaattttt accaggttaa agacattcgg   5700

aggccagaaa ggcgccatag tgacccttgg ggtaggcaag accaacagca actggatagg   5760

ccatttaata ggggtaaagg ggaccgccag agattttata gtgattcaca ccatttgaaa   5820

agagagcgac atgaaaagga atgggagcaa gaatctgaaa ggcatagacg cagagacaga   5880

agccaagaca aggacagaga cagaaaaagc agggaggaag ggcacaaaga taaagagagg   5940

gcacggttat cacatggtga tcgaggaaca gatggaaaag caagcagaga tagtaggaat   6000

gtagacaaga agccagataa acctaaaagt gaagactatg agaaggacaa agaacgagag   6060

aaaagtaaac acagagaagg agaaaaggac agggataggt accacaaaga tagggaccac   6120

actgacagaa ctaaaagcaa aaggtaaaat ttgcaggctg cttcaggatt acatttaaat   6180

aactgttaaa atgttgtatc ttgtaaacaa aagaaagatt gcctgctagg attgtgccat   6240

ctttaaaatt tttactattg gtcatttgca gaacagtaaa ttctgtgtgt tggtacagag   6300

tgctctgtac cagtgctcat catcccttct tcataccaac ggtccctagt tataggaatt   6360

taatattttt aaaagtttta cattgctgta tattcaaaga tttgttttat taatatgcaa   6420

taaaggctta gaaattttag ttttattcct taattggtaa atatggttaa ctatggaata   6480

tatttacttc ctctagtgaa tgtcctttat ataatgacta atttgggagt aatgtgtgct   6540

ctgtaagttt gttttaaatt gcactgtttt taaagaaact gtagaggagc aacaaaaatc   6600

caagcaactt cataatcaga ttatgctaat catttagttg agcagttttt gaccaagaat   6660

cagaagccca aggggtacat ttattgcttt aatctgcact cattgaagtc atttattacc   6720

atatactaca gctttgtggt aggccattat tttcattttc atttttggct cttcagaaac   6780

ttgaatactt aagcttgtac atgatcttgt gttttgctat cctttttact gtaaaatgta   6840

aatattttaa gggatatttt gattctaaat atgataaaat aatttctcac ctattttgtg   6900

tgtgtgactt gaaattcagt agtaaaagaa tttcttcttt aaagcttt                6948


<210>  1828
<211>  2039
<212>  PRT
<213>  Homosapiens

<400>  1828

Met Asp Ile Val Asp Thr Phe Asn His Leu Ile Pro Thr Glu His Leu 
1               5                   10                  15      


Asp Asp Ala Leu Phe Leu Gly Ser Asn Leu Glu Asn Glu Val Cys Glu 
            20                  25                  30          


Asp Phe Ser Ala Ser Gln Asn Val Leu Glu Asp Ser Leu Lys Asn Met 
        35                  40                  45              


Leu Ser Asp Lys Asp Pro Met Leu Gly Ser Ala Ser Asn Gln Phe Cys 
    50                  55                  60                  


Leu Pro Val Leu Asp Ser Asn Asp Pro Asn Phe Gln Met Pro Cys Ser 
65                  70                  75                  80  


Thr Val Val Gly Leu Asp Asp Ile Met Asp Glu Gly Val Val Lys Glu 
                85                  90                  95      


Ser Gly Asn Asp Thr Ile Asp Glu Glu Glu Leu Ile Leu Pro Asn Arg 
            100                 105                 110         


Asn Leu Arg Asp Lys Val Glu Glu Asn Ser Val Arg Ser Pro Arg Lys 
        115                 120                 125             


Ser Pro Arg Leu Met Ala Gln Glu Gln Val Arg Ser Leu Arg Gln Ser 
    130                 135                 140                 


Thr Ile Ala Lys Arg Ser Asn Ala Ala Pro Leu Ser Asn Thr Lys Lys 
145                 150                 155                 160 


Ala Ser Gly Lys Thr Val Ser Thr Ala Lys Ala Gly Val Lys Gln Pro 
                165                 170                 175     


Glu Arg Ser Gln Val Lys Glu Glu Val Cys Met Ser Leu Lys Pro Glu 
            180                 185                 190         


Tyr His Lys Glu Asn Arg Arg Cys Ser Arg Asn Ser Gly Gln Ile Glu 
        195                 200                 205             


Val Val Pro Glu Val Ser Val Ser Ser Ser His Ser Ser Val Ser Ser 
    210                 215                 220                 


Cys Leu Glu Met Lys Asp Glu Asp Gly Leu Asp Ser Lys His Lys Cys 
225                 230                 235                 240 


Asn Asn Pro Gly Glu Ile Asp Val Pro Ser His Glu Leu Asn Cys Ser 
                245                 250                 255     


Leu Leu Ser Glu Thr Cys Val Thr Ile Gly Glu Lys Lys Asn Glu Ala 
            260                 265                 270         


Leu Met Glu Cys Lys Ala Lys Pro Val Gly Ser Pro Leu Phe Lys Phe 
        275                 280                 285             


Ser Asp Lys Glu Glu His Glu Gln Asn Asp Ser Ile Ser Gly Lys Thr 
    290                 295                 300                 


Gly Glu Thr Val Val Glu Glu Met Ile Ala Thr Arg Lys Val Glu Gln 
305                 310                 315                 320 


Asp Ser Lys Glu Thr Val Lys Leu Ser His Glu Asp Asp His Ile Leu 
                325                 330                 335     


Glu Asp Ala Gly Ser Ser Asp Ile Ser Ser Asp Ala Ala Cys Thr Asn 
            340                 345                 350         


Pro Asn Lys Thr Glu Asn Ser Leu Val Gly Leu Pro Ser Cys Val Asp 
        355                 360                 365             


Glu Val Thr Glu Cys Asn Leu Glu Leu Lys Asp Thr Met Gly Ile Ala 
    370                 375                 380                 


Asp Lys Thr Glu Asn Thr Leu Glu Arg Asn Lys Ile Glu Pro Leu Gly 
385                 390                 395                 400 


Tyr Cys Glu Asp Ala Glu Ser Asn Arg Gln Leu Glu Ser Thr Glu Phe 
                405                 410                 415     


Asn Lys Ser Asn Leu Glu Val Val Asp Thr Ser Thr Phe Gly Pro Glu 
            420                 425                 430         


Ser Asn Ile Leu Glu Asn Ala Ile Cys Asp Val Pro Asp Gln Asn Ser 
        435                 440                 445             


Lys Gln Leu Asn Ala Ile Glu Ser Thr Lys Ile Glu Ser His Glu Thr 
    450                 455                 460                 


Ala Asn Leu Gln Asp Asp Arg Asn Ser Gln Ser Ser Ser Val Ser Tyr 
465                 470                 475                 480 


Leu Glu Ser Lys Ser Val Lys Ser Lys His Thr Lys Pro Val Ile His 
                485                 490                 495     


Ser Lys Gln Asn Met Thr Thr Asp Ala Pro Lys Lys Ile Val Ala Ala 
            500                 505                 510         


Lys Tyr Glu Val Ile His Ser Lys Thr Lys Val Asn Val Lys Ser Val 
        515                 520                 525             


Lys Arg Asn Thr Asp Val Pro Glu Ser Gln Gln Asn Phe His Arg Pro 
    530                 535                 540                 


Val Lys Val Arg Lys Lys Gln Ile Asp Lys Glu Pro Lys Ile Gln Ser 
545                 550                 555                 560 


Cys Asn Ser Gly Val Lys Ser Val Lys Asn Gln Ala His Ser Val Leu 
                565                 570                 575     


Lys Lys Thr Leu Gln Asp Gln Thr Leu Val Gln Ile Phe Lys Pro Leu 
            580                 585                 590         


Thr His Ser Leu Ser Asp Lys Ser His Ala His Pro Gly Cys Leu Lys 
        595                 600                 605             


Glu Pro His His Pro Ala Gln Thr Gly His Val Ser His Ser Ser Gln 
    610                 615                 620                 


Lys Gln Cys His Lys Pro Gln Gln Gln Ala Pro Ala Met Lys Thr Asn 
625                 630                 635                 640 


Ser His Val Lys Glu Glu Leu Glu His Pro Gly Val Glu His Phe Lys 
                645                 650                 655     


Glu Glu Asp Lys Leu Lys Leu Lys Lys Pro Glu Lys Asn Leu Gln Pro 
            660                 665                 670         


Arg Gln Arg Arg Ser Ser Lys Ser Phe Ser Leu Asp Glu Pro Pro Leu 
        675                 680                 685             


Phe Ile Pro Asp Asn Ile Ala Thr Ile Arg Arg Glu Gly Ser Asp His 
    690                 695                 700                 


Ser Ser Ser Phe Glu Ser Lys Tyr Met Trp Thr Pro Ser Lys Gln Cys 
705                 710                 715                 720 


Gly Phe Cys Lys Lys Pro His Gly Asn Arg Phe Met Val Gly Cys Gly 
                725                 730                 735     


Arg Cys Asp Asp Trp Phe His Gly Asp Cys Val Gly Leu Ser Leu Ser 
            740                 745                 750         


Gln Ala Gln Gln Met Gly Glu Glu Asp Lys Glu Tyr Val Cys Val Lys 
        755                 760                 765             


Cys Cys Ala Glu Glu Asp Lys Lys Thr Glu Ile Leu Asp Pro Asp Thr 
    770                 775                 780                 


Leu Glu Asn Gln Ala Thr Val Glu Phe His Ser Gly Asp Lys Thr Met 
785                 790                 795                 800 


Glu Cys Glu Lys Leu Gly Leu Ser Lys His Thr Thr Asn Asp Arg Thr 
                805                 810                 815     


Lys Tyr Ile Asp Asp Thr Val Lys His Lys Val Lys Ile Leu Lys Arg 
            820                 825                 830         


Glu Ser Gly Glu Gly Arg Asn Ser Ser Asp Cys Arg Asp Asn Glu Ile 
        835                 840                 845             


Lys Lys Trp Gln Leu Ala Pro Leu Arg Lys Met Gly Gln Pro Val Leu 
    850                 855                 860                 


Pro Arg Arg Ser Ser Glu Glu Lys Ser Glu Lys Ile Pro Lys Glu Ser 
865                 870                 875                 880 


Thr Thr Val Thr Cys Thr Gly Glu Lys Ala Ser Lys Pro Gly Thr His 
                885                 890                 895     


Glu Lys Gln Glu Met Lys Lys Lys Lys Val Glu Lys Gly Val Leu Asn 
            900                 905                 910         


Val His Pro Ala Ala Ser Ala Ser Lys Pro Ser Ala Asp Gln Ile Arg 
        915                 920                 925             


Gln Ser Val Arg His Ser Leu Lys Asp Ile Leu Met Lys Arg Leu Thr 
    930                 935                 940                 


Asp Ser Asn Leu Lys Val Pro Glu Glu Lys Ala Ala Lys Val Ala Thr 
945                 950                 955                 960 


Lys Ile Glu Lys Glu Leu Phe Ser Phe Phe Arg Asp Thr Asp Ala Lys 
                965                 970                 975     


Tyr Lys Asn Lys Tyr Arg Ser Leu Met Phe Asn Leu Lys Asp Pro Lys 
            980                 985                 990         


Asn Asn Ile Leu Phe Lys Lys Val  Leu Lys Gly Glu Val  Thr Pro Asp 
        995                 1000                 1005             


His Leu  Ile Arg Met Ser Pro  Glu Glu Leu Ala Ser  Lys Glu Leu 
    1010                 1015                 1020             


Ala Ala  Trp Arg Arg Arg Glu  Asn Arg His Thr Ile  Glu Met Ile 
    1025                 1030                 1035             


Glu Lys  Glu Gln Arg Glu Val  Glu Arg Arg Pro Ile  Thr Lys Ile 
    1040                 1045                 1050             


Thr His  Lys Gly Glu Ile Glu  Ile Glu Ser Asp Ala  Pro Met Lys 
    1055                 1060                 1065             


Glu Gln  Glu Ala Ala Met Glu  Ile Gln Glu Pro Ala  Ala Asn Lys 
    1070                 1075                 1080             


Ser Leu  Glu Lys Pro Glu Gly  Ser Glu Lys Gln Lys  Glu Glu Val 
    1085                 1090                 1095             


Asp Ser  Met Ser Lys Asp Thr  Thr Ser Gln His Arg  Gln His Leu 
    1100                 1105                 1110             


Phe Asp  Leu Asn Cys Lys Ile  Cys Ile Gly Arg Met  Ala Pro Pro 
    1115                 1120                 1125             


Val Asp  Asp Leu Ser Pro Lys  Lys Val Lys Val Val  Val Gly Val 
    1130                 1135                 1140             


Ala Arg  Lys His Ser Asp Asn  Glu Ala Glu Ser Ile  Ala Asp Ala 
    1145                 1150                 1155             


Leu Ser  Ser Thr Ser Asn Ile  Leu Ala Ser Glu Phe  Phe Glu Glu 
    1160                 1165                 1170             


Glu Lys  Gln Glu Ser Pro Lys  Ser Thr Phe Ser Pro  Ala Pro Arg 
    1175                 1180                 1185             


Pro Glu  Met Pro Gly Thr Val  Glu Val Glu Ser Thr  Phe Leu Ala 
    1190                 1195                 1200             


Arg Leu  Asn Phe Ile Trp Lys  Gly Phe Ile Asn Met  Pro Ser Val 
    1205                 1210                 1215             


Ala Lys  Phe Val Thr Lys Ala  Tyr Pro Val Ser Gly  Ser Pro Glu 
    1220                 1225                 1230             


Tyr Leu  Thr Glu Asp Leu Pro  Asp Ser Ile Gln Val  Gly Gly Arg 
    1235                 1240                 1245             


Ile Ser  Pro Gln Thr Val Trp  Asp Tyr Val Glu Lys  Ile Lys Ala 
    1250                 1255                 1260             


Ser Gly  Thr Lys Glu Ile Cys  Val Val Arg Phe Thr  Pro Val Thr 
    1265                 1270                 1275             


Glu Glu  Asp Gln Ile Ser Tyr  Thr Leu Leu Phe Ala  Tyr Phe Ser 
    1280                 1285                 1290             


Ser Arg  Lys Arg Tyr Gly Val  Ala Ala Asn Asn Met  Lys Gln Val 
    1295                 1300                 1305             


Lys Asp  Met Tyr Leu Ile Pro  Leu Gly Ala Thr Asp  Lys Ile Pro 
    1310                 1315                 1320             


His Pro  Leu Val Pro Phe Asp  Gly Pro Gly Leu Glu  Leu His Arg 
    1325                 1330                 1335             


Pro Asn  Leu Leu Leu Gly Leu  Ile Ile Arg Gln Lys  Leu Lys Arg 
    1340                 1345                 1350             


Gln His  Ser Ala Cys Ala Ser  Thr Ser His Ile Ala  Glu Thr Pro 
    1355                 1360                 1365             


Glu Ser  Ala Pro Pro Ile Ala  Leu Pro Pro Asp Lys  Lys Ser Lys 
    1370                 1375                 1380             


Ile Glu  Val Ser Thr Glu Glu  Ala Pro Glu Glu Glu  Asn Asp Phe 
    1385                 1390                 1395             


Phe Asn  Ser Phe Thr Thr Val  Leu His Lys Gln Arg  Asn Lys Pro 
    1400                 1405                 1410             


Gln Gln  Asn Leu Gln Glu Asp  Leu Pro Thr Ala Val  Glu Pro Leu 
    1415                 1420                 1425             


Met Glu  Val Thr Lys Gln Glu  Pro Pro Lys Pro Leu  Arg Phe Leu 
    1430                 1435                 1440             


Pro Gly  Val Leu Ile Gly Trp  Glu Asn Gln Pro Thr  Thr Leu Glu 
    1445                 1450                 1455             


Leu Ala  Asn Lys Pro Leu Pro  Val Asp Asp Ile Leu  Gln Ser Leu 
    1460                 1465                 1470             


Leu Gly  Thr Thr Gly Gln Val  Tyr Asp Gln Ala Gln  Ser Val Met 
    1475                 1480                 1485             


Glu Gln  Asn Thr Val Lys Glu  Ile Pro Phe Leu Asn  Glu Gln Thr 
    1490                 1495                 1500             


Asn Ser  Lys Ile Glu Lys Thr  Asp Asn Val Glu Val  Thr Asp Gly 
    1505                 1510                 1515             


Glu Asn  Lys Glu Ile Lys Val  Lys Val Asp Asn Ile  Ser Glu Ser 
    1520                 1525                 1530             


Thr Asp  Lys Ser Ala Glu Ile  Glu Thr Ser Val Val  Gly Ser Ser 
    1535                 1540                 1545             


Ser Ile  Ser Ala Gly Ser Leu  Thr Ser Leu Ser Leu  Arg Gly Lys 
    1550                 1555                 1560             


Pro Pro  Asp Val Ser Thr Glu  Ala Phe Leu Thr Asn  Leu Ser Ile 
    1565                 1570                 1575             


Gln Ser  Lys Gln Glu Glu Thr  Val Glu Ser Lys Glu  Lys Thr Leu 
    1580                 1585                 1590             


Lys Arg  Gln Leu Gln Glu Asp  Gln Glu Asn Asn Leu  Gln Asp Asn 
    1595                 1600                 1605             


Gln Thr  Ser Asn Ser Ser Pro  Cys Arg Ser Asn Val  Gly Lys Gly 
    1610                 1615                 1620             


Asn Ile  Asp Gly Asn Val Ser  Cys Ser Glu Asn Leu  Val Ala Asn 
    1625                 1630                 1635             


Thr Ala  Arg Ser Pro Gln Phe  Ile Asn Leu Lys Arg  Asp Pro Arg 
    1640                 1645                 1650             


Gln Ala  Ala Gly Arg Ser Gln  Pro Val Thr Thr Ser  Glu Ser Lys 
    1655                 1660                 1665             


Asp Gly  Asp Ser Cys Arg Asn  Gly Glu Lys His Met  Leu Pro Gly 
    1670                 1675                 1680             


Leu Ser  His Asn Lys Glu His  Leu Thr Glu Gln Ile  Asn Val Glu 
    1685                 1690                 1695             


Glu Lys  Leu Cys Ser Ala Glu  Lys Asn Ser Cys Val  Gln Gln Ser 
    1700                 1705                 1710             


Asp Asn  Leu Lys Val Ala Gln  Asn Ser Pro Ser Val  Glu Asn Ile 
    1715                 1720                 1725             


Gln Thr  Ser Gln Ala Glu Gln  Ala Lys Pro Leu Gln  Glu Asp Ile 
    1730                 1735                 1740             


Leu Met  Gln Asn Ile Glu Thr  Val His Pro Phe Arg  Arg Gly Ser 
    1745                 1750                 1755             


Ala Val  Ala Thr Ser His Phe  Glu Val Gly Asn Thr  Cys Pro Ser 
    1760                 1765                 1770             


Glu Phe  Pro Ser Lys Ser Ile  Thr Phe Thr Ser Arg  Ser Thr Ser 
    1775                 1780                 1785             


Pro Arg  Thr Ser Thr Asn Phe  Ser Pro Met Arg Pro  Gln Gln Pro 
    1790                 1795                 1800             


Asn Leu  Gln His Leu Lys Ser  Ser Pro Pro Gly Phe  Pro Phe Pro 
    1805                 1810                 1815             


Gly Pro  Pro Asn Phe Pro Pro  Gln Ser Met Phe Gly  Phe Pro Pro 
    1820                 1825                 1830             


His Leu  Pro Pro Pro Leu Leu  Pro Pro Pro Gly Phe  Gly Phe Ala 
    1835                 1840                 1845             


Gln Asn  Pro Met Val Pro Trp  Pro Pro Val Val His  Leu Pro Gly 
    1850                 1855                 1860             


Gln Pro  Gln Arg Met Met Gly  Pro Leu Ser Gln Ala  Ser Arg Tyr 
    1865                 1870                 1875             


Ile Gly  Pro Gln Asn Phe Tyr  Gln Val Lys Asp Ile  Arg Arg Pro 
    1880                 1885                 1890             


Glu Arg  Arg His Ser Asp Pro  Trp Gly Arg Gln Asp  Gln Gln Gln 
    1895                 1900                 1905             


Leu Asp  Arg Pro Phe Asn Arg  Gly Lys Gly Asp Arg  Gln Arg Phe 
    1910                 1915                 1920             


Tyr Ser  Asp Ser His His Leu  Lys Arg Glu Arg His  Glu Lys Glu 
    1925                 1930                 1935             


Trp Glu  Gln Glu Ser Glu Arg  His Arg Arg Arg Asp  Arg Ser Gln 
    1940                 1945                 1950             


Asp Lys  Asp Arg Asp Arg Lys  Ser Arg Glu Glu Gly  His Lys Asp 
    1955                 1960                 1965             


Lys Glu  Arg Ala Arg Leu Ser  His Gly Asp Arg Gly  Thr Asp Gly 
    1970                 1975                 1980             


Lys Ala  Ser Arg Asp Ser Arg  Asn Val Asp Lys Lys  Pro Asp Lys 
    1985                 1990                 1995             


Pro Lys  Ser Glu Asp Tyr Glu  Lys Asp Lys Glu Arg  Glu Lys Ser 
    2000                 2005                 2010             


Lys His  Arg Glu Gly Glu Lys  Asp Arg Asp Arg Tyr  His Lys Asp 
    2015                 2020                 2025             


Arg Asp  His Thr Asp Arg Thr  Lys Ser Lys Arg 
    2030                 2035                 


<210>  1829
<211>  1142
<212>  DNA
<213>  Homosapiens

<400>  1829
atgtctccta caaagaatgc aaaagcgagt cttattcacc acttggcaca tggatccatc     60

catgatgtag gtgcacaaca aactttggat ggcagcaatt gccaaaataa atatggtcct    120

ctggtgtata gtgataatga aaatctgttt tgtgagtgtc caaggctgta ttcaggcaag    180

ctgtgccagt ttgcaagttg tgaaaacaac ccatgtggaa atggtgccac ctgtgttcca    240

aaatccggaa cagatattgt ctgcctctgc ccatatggga ggtctggacc cctctgcact    300

gatgctatta atattactca gccaaggttc agtggcacag atgcctttgg atacacctca    360

ttcctggctt attcacggat ctcagacatc agcttccatt atgaattcca cctgaagttt    420

cagctggcaa acaaccactc agcactgcaa aataacttga tattttttac tggacagaaa    480

ggccatgggt tgaatggcga tgacttcctg gctgtgggcc tgctcaatgg cagtgtggtt    540

tatagttata acctggggtc tggcatagca agcatcagga gcgagcccct caatctgagc    600

cttggagtcc acactgttca tctgggcaag ttcttccaag agggctggct gaaggtagat    660

gatcataaaa ataaatccat tatcgcccca ggaagactgg ttggtctcaa tgtcttcagt    720

cagttttatg taggtggcta cagtgaatac actccagatc tcttaccaaa tggagcagat    780

tttaaaaatg gttttcaagt tcaaaaggca agagacagac tgcagtcaac ccatccatac    840

caccaagggg tagcccacag aggccagagc aagccaagag gattaaggac aacattgtgc    900

ttggaaacat taagattgca cactcctgga agtatgtcaa ctgccacagt ctttatctcg    960

ctgtgtcatc aaggctggag tacagtggtg ccatctcagc tcactgcaac cttcatctcc   1020

agggctcaat caatcctccc accttagcct ctcatgtagc tgagccacta aacccagcta   1080

acatatcctt acaaagctga tttatattgt agtagagtta taaaataaag acatgcttta   1140

aa                                                                  1142


<210>  1830
<211>  348
<212>  PRT
<213>  Homosapiens

<400>  1830

Met Ser Pro Thr Lys Asn Ala Lys Ala Ser Leu Ile His His Leu Ala 
1               5                   10                  15      


His Gly Ser Ile His Asp Val Gly Ala Gln Gln Thr Leu Asp Gly Ser 
            20                  25                  30          


Asn Cys Gln Asn Lys Tyr Gly Pro Leu Val Tyr Ser Asp Asn Glu Asn 
        35                  40                  45              


Leu Phe Cys Glu Cys Pro Arg Leu Tyr Ser Gly Lys Leu Cys Gln Phe 
    50                  55                  60                  


Ala Ser Cys Glu Asn Asn Pro Cys Gly Asn Gly Ala Thr Cys Val Pro 
65                  70                  75                  80  


Lys Ser Gly Thr Asp Ile Val Cys Leu Cys Pro Tyr Gly Arg Ser Gly 
                85                  90                  95      


Pro Leu Cys Thr Asp Ala Ile Asn Ile Thr Gln Pro Arg Phe Ser Gly 
            100                 105                 110         


Thr Asp Ala Phe Gly Tyr Thr Ser Phe Leu Ala Tyr Ser Arg Ile Ser 
        115                 120                 125             


Asp Ile Ser Phe His Tyr Glu Phe His Leu Lys Phe Gln Leu Ala Asn 
    130                 135                 140                 


Asn His Ser Ala Leu Gln Asn Asn Leu Ile Phe Phe Thr Gly Gln Lys 
145                 150                 155                 160 


Gly His Gly Leu Asn Gly Asp Asp Phe Leu Ala Val Gly Leu Leu Asn 
                165                 170                 175     


Gly Ser Val Val Tyr Ser Tyr Asn Leu Gly Ser Gly Ile Ala Ser Ile 
            180                 185                 190         


Arg Ser Glu Pro Leu Asn Leu Ser Leu Gly Val His Thr Val His Leu 
        195                 200                 205             


Gly Lys Phe Phe Gln Glu Gly Trp Leu Lys Val Asp Asp His Lys Asn 
    210                 215                 220                 


Lys Ser Ile Ile Ala Pro Gly Arg Leu Val Gly Leu Asn Val Phe Ser 
225                 230                 235                 240 


Gln Phe Tyr Val Gly Gly Tyr Ser Glu Tyr Thr Pro Asp Leu Leu Pro 
                245                 250                 255     


Asn Gly Ala Asp Phe Lys Asn Gly Phe Gln Val Gln Lys Ala Arg Asp 
            260                 265                 270         


Arg Leu Gln Ser Thr His Pro Tyr His Gln Gly Val Ala His Arg Gly 
        275                 280                 285             


Gln Ser Lys Pro Arg Gly Leu Arg Thr Thr Leu Cys Leu Glu Thr Leu 
    290                 295                 300                 


Arg Leu His Thr Pro Gly Ser Met Ser Thr Ala Thr Val Phe Ile Ser 
305                 310                 315                 320 


Leu Cys His Gln Gly Trp Ser Thr Val Val Pro Ser Gln Leu Thr Ala 
                325                 330                 335     


Thr Phe Ile Ser Arg Ala Gln Ser Ile Leu Pro Pro 
            340                 345             


<210>  1831
<211>  3325
<212>  DNA
<213>  Homosapiens

<400>  1831
tccttgaaac ccgccggcgc acatgaggcc gctgcccccg ccgcaggcgc tggcggcccc     60

ctcgcggtgc ccgtggtgat gccatgcccc gccaccacgc gggaggagag gagggcggcg    120

ccgccgggct ctgggtgaag agcggcgcag cggcggcggc ggcgggcggg gggcgcttgg    180

gcagcggcat gaaggatgtg gagtcgggcc ggggcagggt gctgctgaac tcggcagccg    240

ccaggggcga cggcctgcta ctgctgggca cccgcgcggc cacgctcggt ggcggcggcg    300

gtggcctgag ggagagccgc cggggcaagc agggggcccg gatgagcctg ctggggaagc    360

cgctctctta cacgagtagc cagagctgcc ggcgcaacgt caagtaccgg cgggtgcaga    420

actacctgta caacgtgctg gagagacccc gcggctgggc gttcatctac cacgctttcg    480

tttttctcct tgtctttggt tgcttgattt tgtcagtgtt ttctaccatc cctgagcaca    540

caaaattggc ctcaagttgc ctcttgatcc tggagttcgt gatgattgtc gtctttggtt    600

tggagttcat cattcgaatc tggtctgcgg gttgctgttg tcgatataga ggatggcaag    660

gaagactgag gtttgctcga aagcccttct gtgttataga taccattgtt cttatcgctt    720

caatagcagt tgtttctgca aaaactcagg gtaatatttt tgccacgtct gcactcagaa    780

gtctccgttt cctacagatc ctccgcatgg tgcgcatgga ccgaagggga ggcacttgga    840

aattactggg ttcagtggtt tatgctcaca gcaaggaatt aatcacagct tggtacatag    900

gatttttggt tcttattttt tcgtctttcc ttgtctatct ggtggaaaag gatgccaata    960

aagagttttc tacatatgca gatgctctct ggtggggcac aattacattg acaactattg   1020

gctatggaga caaaactccc ctaacttggc tgggaagatt gctttctgca ggctttgcac   1080

tccttggcat ttctttcttt gcacttcctg ccggcattct tggctcaggt tttgcattaa   1140

aagtacaaga acaacaccgc cagaaacact ttgagaaaag aaggaaccca gctgccaacc   1200

tcattcagtg tgtttggcgt agttacgcag ctgatgagaa atctgtttcc attgcaacct   1260

ggaagccaca cttgaaggcc ttgcacacct gcagccctac caagaaagaa caaggggaag   1320

catcaagcag tcagaagcta agttttaagg agcgagtgcg catggctagc cccaggggcc   1380

agagtattaa gagccgacaa gcctcagtag gtgacaggag gtccccaagc accgacatca   1440

cagccgaggg cagtcccacc aaagtgcaga agagctggag cttcaacgac cgaacccgct   1500

tccggccctc gctgcgcctc aaaagttctc agccaaaacc agtgatagat gctgacacag   1560

cccttggcac tgatgatgta tatgatgaaa aaggatgcca gtgtgatgta tcagtggaag   1620

acctcacccc accacttaaa actgtcattc gagctatcag aattatgaaa tttcatgttg   1680

caaaacggaa gtttaaggaa acattacgtc catatgatgt aaaagatgtc attgaacaat   1740

attctgctgg tcatctggac atgttgtgta gaattaaaag ccttcaaaca cgtgttgatc   1800

aaattcttgg aaaagggcaa atcacatcag ataagaagag ccgagagaaa ataacagcag   1860

aacatgagac cacagacgat ctcagtatgc tcggtcgggt ggtcaaggtt gaaaaacagg   1920

tacagtccat agaatccaag ctggactgcc tactagacat ctatcaacag gtccttcgga   1980

aaggctctgc ctcagccctc gctttggctt cattccagat cccacctttt gaatgtgaac   2040

agacatctga ctatcaaagc cctgtggata gcaaagatct ttcgggttcc gcacaaaaca   2100

gtggctgctt atccagatca actagtgcca acatctcgag aggcctgcag ttcattctga   2160

cgccaaatga gttcagtgcc cagactttct acgcgcttag ccctactatg cacagtcaag   2220

caacacaggt gccaattagt caaagcgatg gctcagcagt ggcagccacc aacaccattg   2280

caaaccaaat aaatacggca cccaagccag cagccccaac aactttacag atcccacctc   2340

ctctcccagc catcaagcat ctgcccaggc cagaaactct gcaccctaac cctgcaggct   2400

tacaggaaag catttctgac gtcaccacct gccttgttgc ctccaaggaa aatgttcagg   2460

ttgcacagtc aaatctcacc aaggaccgtt ctatgaggaa aagctttgac atgggaggag   2520

aaactctgtt gtctgtctgt cccatggtgc cgaaggactt gggcaaatct ttgtctgtgc   2580

aaaacctgat caggtcgacc gaggaactga atatacaact ttcagggagt gagtcaagtg   2640

gctccagagg cagccaagat ttttacccca aatggaggga atccaaattg tttataactg   2700

atgaagaggt gggtcccgaa gagacagaga cagacacttt tgatgccgca ccgcagcctg   2760

ccagggaagc tgcctttgca tcagactctc taaggactgg aaggtcacga tcatctcaga   2820

gcatttgtaa ggcaggagaa agtacagatg ccctcagctt gcctcatgtc aaactgaaat   2880

aagttcttca ttttctttcc aggcatagca gttctttagc catacatatc attgcatgaa   2940

ctatttcgaa agcccttcta aaaagttgaa attgcaagaa tcgggaagaa catgaaaggc   3000

agtttataag cccgttacct tttaattgca tgaaaatgca tgtttaggga tggctaaaat   3060

tccaaggtgc atcgacatta acccactcat ttagtaatgt accttgagtt aaaaagcctg   3120

agaaaccaaa cacagctaat gctatggggt gtatgaatat gtcaagttta ggtcatttag   3180

aagatttgac actgtatttt gaaattatgg gagtaaacac cttcaaattt caggcatttc   3240

tgctttgtga ctaaatacaa actacatttt caagattagg ccataatgta tatttaaaca   3300

caatggctat caacagctgc taata                                         3325


<210>  1832
<211>  932
<212>  PRT
<213>  Homosapiens

<400>  1832

Met Pro Arg His His Ala Gly Gly Glu Glu Gly Gly Ala Ala Gly Leu 
1               5                   10                  15      


Trp Val Lys Ser Gly Ala Ala Ala Ala Ala Ala Gly Gly Gly Arg Leu 
            20                  25                  30          


Gly Ser Gly Met Lys Asp Val Glu Ser Gly Arg Gly Arg Val Leu Leu 
        35                  40                  45              


Asn Ser Ala Ala Ala Arg Gly Asp Gly Leu Leu Leu Leu Gly Thr Arg 
    50                  55                  60                  


Ala Ala Thr Leu Gly Gly Gly Gly Gly Gly Leu Arg Glu Ser Arg Arg 
65                  70                  75                  80  


Gly Lys Gln Gly Ala Arg Met Ser Leu Leu Gly Lys Pro Leu Ser Tyr 
                85                  90                  95      


Thr Ser Ser Gln Ser Cys Arg Arg Asn Val Lys Tyr Arg Arg Val Gln 
            100                 105                 110         


Asn Tyr Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile 
        115                 120                 125             


Tyr His Ala Phe Val Phe Leu Leu Val Phe Gly Cys Leu Ile Leu Ser 
    130                 135                 140                 


Val Phe Ser Thr Ile Pro Glu His Thr Lys Leu Ala Ser Ser Cys Leu 
145                 150                 155                 160 


Leu Ile Leu Glu Phe Val Met Ile Val Val Phe Gly Leu Glu Phe Ile 
                165                 170                 175     


Ile Arg Ile Trp Ser Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Gln 
            180                 185                 190         


Gly Arg Leu Arg Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Thr Ile 
        195                 200                 205             


Val Leu Ile Ala Ser Ile Ala Val Val Ser Ala Lys Thr Gln Gly Asn 
    210                 215                 220                 


Ile Phe Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu 
225                 230                 235                 240 


Arg Met Val Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly 
                245                 250                 255     


Ser Val Val Tyr Ala His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile 
            260                 265                 270         


Gly Phe Leu Val Leu Ile Phe Ser Ser Phe Leu Val Tyr Leu Val Glu 
        275                 280                 285             


Lys Asp Ala Asn Lys Glu Phe Ser Thr Tyr Ala Asp Ala Leu Trp Trp 
    290                 295                 300                 


Gly Thr Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Thr Pro Leu 
305                 310                 315                 320 


Thr Trp Leu Gly Arg Leu Leu Ser Ala Gly Phe Ala Leu Leu Gly Ile 
                325                 330                 335     


Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu 
            340                 345                 350         


Lys Val Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn 
        355                 360                 365             


Pro Ala Ala Asn Leu Ile Gln Cys Val Trp Arg Ser Tyr Ala Ala Asp 
    370                 375                 380                 


Glu Lys Ser Val Ser Ile Ala Thr Trp Lys Pro His Leu Lys Ala Leu 
385                 390                 395                 400 


His Thr Cys Ser Pro Thr Lys Lys Glu Gln Gly Glu Ala Ser Ser Ser 
                405                 410                 415     


Gln Lys Leu Ser Phe Lys Glu Arg Val Arg Met Ala Ser Pro Arg Gly 
            420                 425                 430         


Gln Ser Ile Lys Ser Arg Gln Ala Ser Val Gly Asp Arg Arg Ser Pro 
        435                 440                 445             


Ser Thr Asp Ile Thr Ala Glu Gly Ser Pro Thr Lys Val Gln Lys Ser 
    450                 455                 460                 


Trp Ser Phe Asn Asp Arg Thr Arg Phe Arg Pro Ser Leu Arg Leu Lys 
465                 470                 475                 480 


Ser Ser Gln Pro Lys Pro Val Ile Asp Ala Asp Thr Ala Leu Gly Thr 
                485                 490                 495     


Asp Asp Val Tyr Asp Glu Lys Gly Cys Gln Cys Asp Val Ser Val Glu 
            500                 505                 510         


Asp Leu Thr Pro Pro Leu Lys Thr Val Ile Arg Ala Ile Arg Ile Met 
        515                 520                 525             


Lys Phe His Val Ala Lys Arg Lys Phe Lys Glu Thr Leu Arg Pro Tyr 
    530                 535                 540                 


Asp Val Lys Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met 
545                 550                 555                 560 


Leu Cys Arg Ile Lys Ser Leu Gln Thr Arg Val Asp Gln Ile Leu Gly 
                565                 570                 575     


Lys Gly Gln Ile Thr Ser Asp Lys Lys Ser Arg Glu Lys Ile Thr Ala 
            580                 585                 590         


Glu His Glu Thr Thr Asp Asp Leu Ser Met Leu Gly Arg Val Val Lys 
        595                 600                 605             


Val Glu Lys Gln Val Gln Ser Ile Glu Ser Lys Leu Asp Cys Leu Leu 
    610                 615                 620                 


Asp Ile Tyr Gln Gln Val Leu Arg Lys Gly Ser Ala Ser Ala Leu Ala 
625                 630                 635                 640 


Leu Ala Ser Phe Gln Ile Pro Pro Phe Glu Cys Glu Gln Thr Ser Asp 
                645                 650                 655     


Tyr Gln Ser Pro Val Asp Ser Lys Asp Leu Ser Gly Ser Ala Gln Asn 
            660                 665                 670         


Ser Gly Cys Leu Ser Arg Ser Thr Ser Ala Asn Ile Ser Arg Gly Leu 
        675                 680                 685             


Gln Phe Ile Leu Thr Pro Asn Glu Phe Ser Ala Gln Thr Phe Tyr Ala 
    690                 695                 700                 


Leu Ser Pro Thr Met His Ser Gln Ala Thr Gln Val Pro Ile Ser Gln 
705                 710                 715                 720 


Ser Asp Gly Ser Ala Val Ala Ala Thr Asn Thr Ile Ala Asn Gln Ile 
                725                 730                 735     


Asn Thr Ala Pro Lys Pro Ala Ala Pro Thr Thr Leu Gln Ile Pro Pro 
            740                 745                 750         


Pro Leu Pro Ala Ile Lys His Leu Pro Arg Pro Glu Thr Leu His Pro 
        755                 760                 765             


Asn Pro Ala Gly Leu Gln Glu Ser Ile Ser Asp Val Thr Thr Cys Leu 
    770                 775                 780                 


Val Ala Ser Lys Glu Asn Val Gln Val Ala Gln Ser Asn Leu Thr Lys 
785                 790                 795                 800 


Asp Arg Ser Met Arg Lys Ser Phe Asp Met Gly Gly Glu Thr Leu Leu 
                805                 810                 815     


Ser Val Cys Pro Met Val Pro Lys Asp Leu Gly Lys Ser Leu Ser Val 
            820                 825                 830         


Gln Asn Leu Ile Arg Ser Thr Glu Glu Leu Asn Ile Gln Leu Ser Gly 
        835                 840                 845             


Ser Glu Ser Ser Gly Ser Arg Gly Ser Gln Asp Phe Tyr Pro Lys Trp 
    850                 855                 860                 


Arg Glu Ser Lys Leu Phe Ile Thr Asp Glu Glu Val Gly Pro Glu Glu 
865                 870                 875                 880 


Thr Glu Thr Asp Thr Phe Asp Ala Ala Pro Gln Pro Ala Arg Glu Ala 
                885                 890                 895     


Ala Phe Ala Ser Asp Ser Leu Arg Thr Gly Arg Ser Arg Ser Ser Gln 
            900                 905                 910         


Ser Ile Cys Lys Ala Gly Glu Ser Thr Asp Ala Leu Ser Leu Pro His 
        915                 920                 925             


Val Lys Leu Lys 
    930         


<210>  1833
<211>  1998
<212>  DNA
<213>  Homosapiens

<400>  1833
acttccgctc gagcgcgcct cgcgcggccg cggcgcgagc cgggacccct ggaagggtcg     60

ggtgcgcggc ccaggaggta ccgctgtctc ctcacaatcg gccaggcctg cagccgctgc    120

cgccgccgcc gccgccgccg ccctactcag ggagtggccc aggcctgcgg cgcgccaccc    180

tcacctcctt cattcctacc gtcaaagccc agccttggct acctgacccc cctgtggtct    240

cgaactcggt tagtccggtg aagggacaga gaagcctggg ttcccggcgg catcactgag    300

atgctcagtc ctgaattctg ccctccatta ggattatctg ctttgtggga taatttcctc    360

attggttgag tcagtgagtt gcgtgtctgc aagagagcat cctatctggt cggagcagag    420

catggacatg ggaacgagtg ctctcagcaa gaagccgtgg tggaccctgc ctcaaaactt    480

tcatgcacca atggtgtttc acatggaaga ggaccaggag gagctcatct tcgggcatgg    540

tgacacatac cttcgctgca ttgaggtgca cagccacacc cttattcagc tggagagttg    600

gttcacagct acaggccaga ctcgtgtgac tgtagtcgga ccacacaggg caaggcagtg    660

gctgctgcac atgttttgtt gtgtggggag ccaggactcc tatcatcatg ctcgaggtgg    720

gagcacagca tggccgtggg aacgagtgct ctcagcaagg agccgtggtg gaccctgccc    780

gaaaactttc attctccaat ggtgttccac atggaagagg accaggagga gctcatcttc    840

ggacttgatg acacgtacct tcgctgcatt gagctgcaca gccacaccct tattcagctg    900

gaggtgtttc acagctacag gccagacacg tgtgactgta gtcggaccac caatggcaaa    960

gcagtggctg ctgctcatgt tccattgcgt ggggagccag gactccaagt gtcacgctcg   1020

aggtctgaag atgctagagc gtgtccgaag ccagcccctg accaatgatg acctggtcac   1080

ctccgttagc ctgccaccgt acaccggaga ctgatctccc ctgggaagag gggatgagag   1140

gagaagtctt ggcttcgctt ttgatggagt cttactctgt cgcccaggct ggagtacaat   1200

ggtgcgaact cagccacctg ctacctctgc cttctgggtt caagcaattc tctgcctcag   1260

cctcctgagt aactggaatt gcaggtcaga gcagagcatg gccatgggaa caagtgccct   1320

cagcaagaag ccgtggtaga ccctgcctga aaactttcat gatccaatgg tgtttcacat   1380

ggaagaggac caggaggagc tcatctttgg tgagtggcct ttgcccacat cccctccttc   1440

atccttgtct tctccatttt caatttttcc cttctttcct accttcatca gtcacacatc   1500

ggttccccca aggctacctc cccactcccc aagggctggt gcttgataga ccctcctctc   1560

gcctcttatg ctcacagggc atggtgacac ataccttcac tgcattgagg tgcacagccc   1620

ctgaccaacc atgatctggt cgcctccatt agtgtgccac cgtacaccag agacctgtct   1680

ttggcctcca ggataagtgg aaccgtctgt cttagcgtac ctcagccttt cccttaccaa   1740

gtgattggtc gttaggtatt ctatttgagt tcactctatt cgtaattaag gacagatctc   1800

ccctgggaag tggggatgag aggagaagtc ttggcttcac ttttggtgag aaagacatga   1860

aagacactga agaaagtttg aacttgtggc ggggacctgt ccctctcagg ccttctaggc   1920

acgtgcctga gggaagtctc ctgagtgtaa gaagtgttat tggcaaagca atccaataaa   1980

ataagctacc tgtgatgc                                                 1998


<210>  1834
<211>  230
<212>  PRT
<213>  Homosapiens

<400>  1834

Met Asp Met Gly Thr Ser Ala Leu Ser Lys Lys Pro Trp Trp Thr Leu 
1               5                   10                  15      


Pro Gln Asn Phe His Ala Pro Met Val Phe His Met Glu Glu Asp Gln 
            20                  25                  30          


Glu Glu Leu Ile Phe Gly His Gly Asp Thr Tyr Leu Arg Cys Ile Glu 
        35                  40                  45              


Val His Ser His Thr Leu Ile Gln Leu Glu Ser Trp Phe Thr Ala Thr 
    50                  55                  60                  


Gly Gln Thr Arg Val Thr Val Val Gly Pro His Arg Ala Arg Gln Trp 
65                  70                  75                  80  


Leu Leu His Met Phe Cys Cys Val Gly Ser Gln Asp Ser Tyr His His 
                85                  90                  95      


Ala Arg Gly Gly Ser Thr Ala Trp Pro Trp Glu Arg Val Leu Ser Ala 
            100                 105                 110         


Arg Ser Arg Gly Gly Pro Cys Pro Lys Thr Phe Ile Leu Gln Trp Cys 
        115                 120                 125             


Ser Thr Trp Lys Arg Thr Arg Arg Ser Ser Ser Ser Asp Leu Met Thr 
    130                 135                 140                 


Arg Thr Phe Ala Ala Leu Ser Cys Thr Ala Thr Pro Leu Phe Ser Trp 
145                 150                 155                 160 


Arg Cys Phe Thr Ala Thr Gly Gln Thr Arg Val Thr Val Val Gly Pro 
                165                 170                 175     


Pro Met Ala Lys Gln Trp Leu Leu Leu Met Phe His Cys Val Gly Ser 
            180                 185                 190         


Gln Asp Ser Lys Cys His Ala Arg Gly Leu Lys Met Leu Glu Arg Val 
        195                 200                 205             


Arg Ser Gln Pro Leu Thr Asn Asp Asp Leu Val Thr Ser Val Ser Leu 
    210                 215                 220                 


Pro Pro Tyr Thr Gly Asp 
225                 230 


<210>  1835
<211>  664
<212>  DNA
<213>  Homosapiens

<400>  1835
gcggctagca gggagagggg cggagaggca gcgaacctct caatgtgcag caggccgcga     60

gggctatata aagctcgggt ctcggaccta ctggaactgg tcaagattgc ccgcgagctg    120

gcagcggcct tccgcccagc tctgcggcgt catggagaac gcgggaggcg cagagggtac    180

agagagtgga gctgcggcgt gcgcggccac cgacggccct acgcggcgcg cgggcgcgga    240

ctccggatac gcaggcttct ggagaccctg ggtggacgcc ggaggcaaga aagaagagga    300

gacgccgaac cacgccgcgg aggcgatgcc cgatggccct ggaatgaccg cagcctcagg    360

aaagctttac caattcaggc acccagtcag actattttgg ccaaaatcaa aatgttatga    420

ttacttatat caagaagcag aagctcttct gaaaaatttt ccaattcaag ccacaatttc    480

attttatgaa gattctgata gcgaagatga aattgaggat ctgacctgtg aaaattaatc    540

tgattagcta cttttgatta tatccaaagc ttgtggggtt taaatttagt gtacaaatgt    600

atcataatta ttttaaacta atttatttgt atataaatta ttaataaaat gaaatatttt    660

gtaa                                                                 664


<210>  1836
<211>  128
<212>  PRT
<213>  Homosapiens

<400>  1836

Met Glu Asn Ala Gly Gly Ala Glu Gly Thr Glu Ser Gly Ala Ala Ala 
1               5                   10                  15      


Cys Ala Ala Thr Asp Gly Pro Thr Arg Arg Ala Gly Ala Asp Ser Gly 
            20                  25                  30          


Tyr Ala Gly Phe Trp Arg Pro Trp Val Asp Ala Gly Gly Lys Lys Glu 
        35                  40                  45              


Glu Glu Thr Pro Asn His Ala Ala Glu Ala Met Pro Asp Gly Pro Gly 
    50                  55                  60                  


Met Thr Ala Ala Ser Gly Lys Leu Tyr Gln Phe Arg His Pro Val Arg 
65                  70                  75                  80  


Leu Phe Trp Pro Lys Ser Lys Cys Tyr Asp Tyr Leu Tyr Gln Glu Ala 
                85                  90                  95      


Glu Ala Leu Leu Lys Asn Phe Pro Ile Gln Ala Thr Ile Ser Phe Tyr 
            100                 105                 110         


Glu Asp Ser Asp Ser Glu Asp Glu Ile Glu Asp Leu Thr Cys Glu Asn 
        115                 120                 125             


<210>  1837
<211>  2259
<212>  DNA
<213>  Homosapiens

<400>  1837
aatgcgcctc acccctggcg accccggaag tgggtcgggg gcttggcctc tgcccggcca     60

cagagccgga gctggaggtg ctgtcccgtc tggcggcgat ccccgggcag ggcccggggc    120

cggggtttga agatgctgaa cgtcccttcc cagtctttcc cggcccccag gtcgcagcag    180

cgtgtcgcct ccggggggcg tagcaaggta cctttaaaac agggcagaag ccttatggat    240

tggattcgac tgaccaaaag tggaaaggat ctaacgggat taaaaggcag gttaattgaa    300

gtaactgaag aagaacttaa gaaacacaac aaaaaagatg attgttggat atgcataaga    360

ggtttcgttt ataatgtcag cccttatatg gagtatcatc ctggtggaga agatgaacta    420

atgagagcag caggatcaga tggtactgaa ctttttgatc aggttcatcg ttgggtcaat    480

tatgaatcca tgctgaaaga atgcctggtt ggcagaatgg ccattaaacc tgctgttctg    540

aaagactatc gtgaggagga aaagaaagtc ttaaatggca tgcttcccaa gagccaagtg    600

acagatacac ttgccaaaga aggtcctagt tatccaagct atgattggtt ccaaacagac    660

tctttagtca ccattgccat atatactaaa cagaaggata tcaatttaga ctcaataata    720

gttgatcatc agaatgattc ctttagagca gaaacaatta ttaaggattg tttatatctt    780

atacatattg ggctaagcca tgaggttcag gaagattttt ctgtgcgggt tgttgagagt    840

gtgggaaaaa tagagattgt tctacaaaaa aaagagaata cttcttggga ctttcttggc    900

catcccctga agaatcataa ttcacttatt ccaaggaaag atacaggttt gtactacaga    960

aagtgccagt taatttccaa ggaagatgtt actcatgata cgaggctttt ctgtttgatg   1020

ctgccaccaa gcactcatct tcaagtgccc attgggcaac atgtttacct caagctacct   1080

attacaggta cagaaatagt aaagccatat acacctgtat ctggttcctt actctcagag   1140

ttcaaggaac cagttcttcc caacaataaa tacatctact ttttgataaa aatctatccc   1200

actggactct tcacaccaga gcttgatcgt cttcagattg gagattttgt ttctgtaagc   1260

agtcctgagg gcaattttaa aatatccaag ttccaagaat tagaagatct ctttttgttg   1320

gcagctggaa caggcttcac accaatggtt aaaatactga attatgcttt gactgatata   1380

cccagtctca ggaaagtgaa gctgatgttc ttcaataaaa cagaagatga tataatttgg   1440

agaagccaat tggagaaatt agcatttaaa gataaaagac tggatgttga atttgttctc   1500

tcagcaccta tttctgaatg gaatggcaaa cagggacata tttcaccagc tcttctttct   1560

gaatttttga aaagaaattt ggacaaatcc aaagttctcg tctgcatttg tggaccagtg   1620

ccatttacag aacaaggagt aaggttgctg catgatctca acttttccaa aaatgagatc   1680

catagtttta cagcataatg aagagctgtc attgtccttt attcaactag tttatctaaa   1740

tttgtgattg cttagggttt tttaagagaa catttttgta cataacaaaa ggttaactag   1800

aatccagcct tcagtttctt aaatgaaatc aaatgttcct tcagtacagg taacttcttg   1860

gctttctttt gtaccacaac ttattttact actgatattt gacctggaaa gttaatcatg   1920

gcaacaaata catacaggat tctttgttat gaatcacaaa tttccttgcc atttaaatta   1980

tatcactgtt ctacaataag cacttgtgtt ttatgacatg ataaagtaaa tgatcacttc   2040

gatcatgttt ctatgctgta aaatgtctta ttagcaatac agattaaatt ttaccttgca   2100

ctgttaactc aggaaatgat catttatgtc cttgttatta atgttaaaac atagaatgtt   2160

ataacttatt aagtgatcca aacatttttt tgtgtgtgta tggcattgat gcagaataga   2220

ataaaattat acttaagttc tttttaaaaa aaaaaaaaa                          2259


<210>  1838
<211>  521
<212>  PRT
<213>  Homosapiens

<400>  1838

Met Leu Asn Val Pro Ser Gln Ser Phe Pro Ala Pro Arg Ser Gln Gln 
1               5                   10                  15      


Arg Val Ala Ser Gly Gly Arg Ser Lys Val Pro Leu Lys Gln Gly Arg 
            20                  25                  30          


Ser Leu Met Asp Trp Ile Arg Leu Thr Lys Ser Gly Lys Asp Leu Thr 
        35                  40                  45              


Gly Leu Lys Gly Arg Leu Ile Glu Val Thr Glu Glu Glu Leu Lys Lys 
    50                  55                  60                  


His Asn Lys Lys Asp Asp Cys Trp Ile Cys Ile Arg Gly Phe Val Tyr 
65                  70                  75                  80  


Asn Val Ser Pro Tyr Met Glu Tyr His Pro Gly Gly Glu Asp Glu Leu 
                85                  90                  95      


Met Arg Ala Ala Gly Ser Asp Gly Thr Glu Leu Phe Asp Gln Val His 
            100                 105                 110         


Arg Trp Val Asn Tyr Glu Ser Met Leu Lys Glu Cys Leu Val Gly Arg 
        115                 120                 125             


Met Ala Ile Lys Pro Ala Val Leu Lys Asp Tyr Arg Glu Glu Glu Lys 
    130                 135                 140                 


Lys Val Leu Asn Gly Met Leu Pro Lys Ser Gln Val Thr Asp Thr Leu 
145                 150                 155                 160 


Ala Lys Glu Gly Pro Ser Tyr Pro Ser Tyr Asp Trp Phe Gln Thr Asp 
                165                 170                 175     


Ser Leu Val Thr Ile Ala Ile Tyr Thr Lys Gln Lys Asp Ile Asn Leu 
            180                 185                 190         


Asp Ser Ile Ile Val Asp His Gln Asn Asp Ser Phe Arg Ala Glu Thr 
        195                 200                 205             


Ile Ile Lys Asp Cys Leu Tyr Leu Ile His Ile Gly Leu Ser His Glu 
    210                 215                 220                 


Val Gln Glu Asp Phe Ser Val Arg Val Val Glu Ser Val Gly Lys Ile 
225                 230                 235                 240 


Glu Ile Val Leu Gln Lys Lys Glu Asn Thr Ser Trp Asp Phe Leu Gly 
                245                 250                 255     


His Pro Leu Lys Asn His Asn Ser Leu Ile Pro Arg Lys Asp Thr Gly 
            260                 265                 270         


Leu Tyr Tyr Arg Lys Cys Gln Leu Ile Ser Lys Glu Asp Val Thr His 
        275                 280                 285             


Asp Thr Arg Leu Phe Cys Leu Met Leu Pro Pro Ser Thr His Leu Gln 
    290                 295                 300                 


Val Pro Ile Gly Gln His Val Tyr Leu Lys Leu Pro Ile Thr Gly Thr 
305                 310                 315                 320 


Glu Ile Val Lys Pro Tyr Thr Pro Val Ser Gly Ser Leu Leu Ser Glu 
                325                 330                 335     


Phe Lys Glu Pro Val Leu Pro Asn Asn Lys Tyr Ile Tyr Phe Leu Ile 
            340                 345                 350         


Lys Ile Tyr Pro Thr Gly Leu Phe Thr Pro Glu Leu Asp Arg Leu Gln 
        355                 360                 365             


Ile Gly Asp Phe Val Ser Val Ser Ser Pro Glu Gly Asn Phe Lys Ile 
    370                 375                 380                 


Ser Lys Phe Gln Glu Leu Glu Asp Leu Phe Leu Leu Ala Ala Gly Thr 
385                 390                 395                 400 


Gly Phe Thr Pro Met Val Lys Ile Leu Asn Tyr Ala Leu Thr Asp Ile 
                405                 410                 415     


Pro Ser Leu Arg Lys Val Lys Leu Met Phe Phe Asn Lys Thr Glu Asp 
            420                 425                 430         


Asp Ile Ile Trp Arg Ser Gln Leu Glu Lys Leu Ala Phe Lys Asp Lys 
        435                 440                 445             


Arg Leu Asp Val Glu Phe Val Leu Ser Ala Pro Ile Ser Glu Trp Asn 
    450                 455                 460                 


Gly Lys Gln Gly His Ile Ser Pro Ala Leu Leu Ser Glu Phe Leu Lys 
465                 470                 475                 480 


Arg Asn Leu Asp Lys Ser Lys Val Leu Val Cys Ile Cys Gly Pro Val 
                485                 490                 495     


Pro Phe Thr Glu Gln Gly Val Arg Leu Leu His Asp Leu Asn Phe Ser 
            500                 505                 510         


Lys Asn Glu Ile His Ser Phe Thr Ala 
        515                 520     


<210>  1839
<211>  2207
<212>  DNA
<213>  Homosapiens

<400>  1839
tccggcgccc cgcgccgcct ccgctgcggg tcgggagcgc gcgtctccgc cgcacctcgg     60

atctaggagc tactcgcccg gccctgggcg gtgggaggcg gcggcggcgg cggcgctcgc    120

gcacctcgga ggagccagga gccggaacca gggccgagcc cgcgggccgg ggctagccag    180

ccggtcggag atgtccgccc agaggttaat ttctaacaga acctcccagc aatcggcatc    240

taattctgat tacacctggg aatatgaata ttatgagatt ggaccagttt cctttgaagg    300

actgaaggct cataaatatt ccattgtgat tggattttgg gttggtcttg cagtcttcgt    360

gatttttatg tttattgtgc tgaccttgct gaccaagaca ggagccccac accaagacaa    420

tgcagagtcc tcagagaaga gattcagaat gaacagcttt gtgtcagact ttggaagacc    480

tctggagcca gataaagtat tttctcgcca aggcaacgag gagtccaggt ctctctttca    540

ctgctacatc aatgaggtgg aacgcttgga cagagccaaa gcttgtcacc agaccacagc    600

ccttgacagt gacgtccaac tccaggaagc catcagaagc agtgggcagc cagaggagga    660

gctgaacagg ctcatgaagt ttgacatccc caactttgtg aacacagacc agaactactt    720

tggggaggat gatcttctga tttctgaacc acctattgtt ctggaaacta agccactttc    780

ccagacctca cacaaagacc tggattgaga aacatgctct gtaaagggtc ttcctgaaga    840

tgtggattct atctttatgt agcaagaaat ctacatccac caaaattgtg tgtgtttggg    900

ggagagagag acatagagat agagacagag aggcagagaa gagacccctt tagaagagag    960

ctgagctgat taagctgagt ggttttttgt tttgttttgt ttttgctttt taatacattt   1020

ggagctttgg gagtattaaa gtatttacac caagcttgtc caacccgtgg catgtgtccc   1080

aggacagctt tgaatgtggc ccaatacaaa ttttaaactt tattaaaaca tgagttttgt   1140

tttttttttt gctatttttt ttaaagctcg tcagctatcg ttagtgttag tgtactttat   1200

gtgtggccca agacaactct tcttccagtg tggcacaggg aagctaaaag attggacacc   1260

tctgatttat actagctcgt tttgcttgtt gaaaaatttg gccaaatacc tattgtcagc   1320

attcttgggt gaggattagc ctaccatgtt ctaatctggc cctgccacta ctatgctcta   1380

cctttggtga gttgctttac ctctctgggc tgccccattt ttaactgtag gttgacaggt   1440

ctagagtgat ccatcccacc tctaatattt tgtgaattta tgactttgcc ttcagatgag   1500

gctgagctat acataaaaca gtataaacta gggtactgcc tcgtatctct tgtaggctct   1560

ctcaaatctc tgtaccttcc acttaaccct aattgagcca agctttagtc aggggatctg   1620

gttgtctacc agaatgtcag gagactcatc ttacacagtc atggtggcca atgtttctgg   1680

tgggttgtgc tgaaacagct cttctgagaa cttccaacca cccatgctct aacctggaga   1740

cagccatccc ctgcctcaga ataagtacca attcgtagta catgtatggt actcttgtcc   1800

ccaagaaatg ttaggaagct tgtcagctga atgagaggag gtgccttctg ggtatctctg   1860

tgttggtgta tctgtgccat tggctacaga acaagaaaaa tactatttgc catgctatta   1920

ccttggcaga tgtgtaggtg atagtcatct ggctttgagc tgagatggtc agtgggttgt   1980

aaattcccca ctagcagata ttcagggtgg cctgagttat gtaaacaagt gagcaacaca   2040

gctttaattt catggaggaa tcaaagctgc acactggtat taaaacaact tgattttgcg   2100

cacacagttg catgcatggc aagctgttaa cctctgggtg gcattttcat tatgaatttg   2160

ttcaccacct gtcttgctta agctacaaaa taaatgcatt tgactgc                 2207


<210>  1840
<211>  205
<212>  PRT
<213>  Homosapiens

<400>  1840

Met Ser Ala Gln Arg Leu Ile Ser Asn Arg Thr Ser Gln Gln Ser Ala 
1               5                   10                  15      


Ser Asn Ser Asp Tyr Thr Trp Glu Tyr Glu Tyr Tyr Glu Ile Gly Pro 
            20                  25                  30          


Val Ser Phe Glu Gly Leu Lys Ala His Lys Tyr Ser Ile Val Ile Gly 
        35                  40                  45              


Phe Trp Val Gly Leu Ala Val Phe Val Ile Phe Met Phe Ile Val Leu 
    50                  55                  60                  


Thr Leu Leu Thr Lys Thr Gly Ala Pro His Gln Asp Asn Ala Glu Ser 
65                  70                  75                  80  


Ser Glu Lys Arg Phe Arg Met Asn Ser Phe Val Ser Asp Phe Gly Arg 
                85                  90                  95      


Pro Leu Glu Pro Asp Lys Val Phe Ser Arg Gln Gly Asn Glu Glu Ser 
            100                 105                 110         


Arg Ser Leu Phe His Cys Tyr Ile Asn Glu Val Glu Arg Leu Asp Arg 
        115                 120                 125             


Ala Lys Ala Cys His Gln Thr Thr Ala Leu Asp Ser Asp Val Gln Leu 
    130                 135                 140                 


Gln Glu Ala Ile Arg Ser Ser Gly Gln Pro Glu Glu Glu Leu Asn Arg 
145                 150                 155                 160 


Leu Met Lys Phe Asp Ile Pro Asn Phe Val Asn Thr Asp Gln Asn Tyr 
                165                 170                 175     


Phe Gly Glu Asp Asp Leu Leu Ile Ser Glu Pro Pro Ile Val Leu Glu 
            180                 185                 190         


Thr Lys Pro Leu Ser Gln Thr Ser His Lys Asp Leu Asp 
        195                 200                 205 


<210>  1841
<211>  5051
<212>  DNA
<213>  Homosapiens

<400>  1841
ggaattcaga ggcagagctt tcagatgatt cttttgaaaa ttcagacaaa acagctagac     60

aatctaaaaa agagatgaag aagaaagata cagtgccttg gtggataact gaagatgatt    120

ttaaagatga tgttatctac tgaactccgg gttattcctc ctcattcctc aaagatttta    180

gctgctgttt cactgacttc ttggaacaaa tgtgagctat ttgaaaacaa agaagacttc    240

tcagcctgtt atggaaatag aagaggagtc tgctgaaaag attcaatttc ttaagagcag    300

tggaacctct ctcttaagta ctgatagctt agaaacaaat gaactagtag tttctgagct    360

caaccatagt agtctcggag tgggattgga cacattagaa gaacaagagg agaaagaaca    420

attttttgcc aggcttgaga aaggcttgac atcttccatt gattattcga gattaaataa    480

ggaattggat tctaatgact ctacacattt taaagcttta catattaatc aagccaacgc    540

agaactaact gatgacgaac atgagaatga atcgaaacat gaagaactgg cagaaaatta    600

cagtgatgat tttgaagatg agtatgttgg tgcaccgttg actactaaag atgaagagat    660

gccttccaaa gagaattcca aatcagaaaa aataagtgtg cccaaacagg aagaagaaaa    720

aactggcatg cttgctaatg ttgtgctgct tgattcatta gactctgttg cagaggtcaa    780

tcttgatgaa caagataaaa taacacctaa gccaaggtgc ctaccagaaa tgactgagaa    840

tgaaatgaca ggaacaggtg tttcttatgg acaaagcagt agtgacgttg aagccctaca    900

tcaagcttat tgtcatatag cccattcatt gggagatgaa gacaaacaaa aaattgagag    960

taacacagtg gaagatatca agagctcagt gaaaggtcat cctcaagaaa atgaagagaa   1020

ttcaaaaaac atctctacta tggaatctga tctgcccaca gtagaggagc tgatgaaacc   1080

tatcagaata gattcctttg ggatcagtgg ttttgattta caacctgtca gctctgagaa   1140

agtggccgaa agaaaagaaa ctgaattttt tagctcttta cccctgaaga tgaacccaaa   1200

tattttgtct caagactcac aacatgtgaa cctttttttt gacaaaaatg atgagaatgt   1260

gattttacaa aagaccacaa atgagagtat ggaaaacagc tgtccacaag taactgaagt   1320

aactgccaca gaagaacatg ttgataaaat gtaccttaat attttgagga aaaaaataac   1380

tgttaattct tcatcattat ctcaggatga caaaattaat aaaacttaca gatctcaact   1440

tagttctgaa gaagaagggg ctgtaatggg taaacaggta ccatacaaga aggccagaag   1500

tgcacctcct ttacttaaaa ggaaacccca gagtggatta tatgcgtcag ttaggagctc   1560

aggctatggc aaacccagtt caccactcaa gatgttttct actcttgaaa agaaaacttc   1620

agaggacatt ataaaaagca aaaacttgag atcgatttct acctccaatc aacctaggaa   1680

aaaagaaatc ttatctggaa caaaactcat caagcctgca gctttggata aaccagctca   1740

caaaactgaa agttgcctgt ctactcgtaa gaagtctgaa aatcccacag aaactgattc   1800

ctgtattcag tttcagactg attccttagg atactgtggt gagaacaagg agaagaaatt   1860

acttatgttt aaaagagttc aggaagcaga ggataaatgg aggggtgcgc aagccctaat   1920

tgagcaaatt aaagccacat tctcagaaaa ggagaaagaa ctagaaaata agttggaaga   1980

actaaagaaa caacaggaaa aagaactctt caaattgaat caagataatt atattcttca   2040

agccaagtta agcagctttg aagaaacaaa caaaaaacaa aggtggttac attttggaga   2100

agcagctgat cctgtcactg gagaaaagtt gaagcaaatc caaaaagaaa tacaagaaca   2160

agagacactt cttcaaggat atcaacagga aaatgaacga ttatataatc aagtaaaaga   2220

tctccaagaa caaaacaaga aaaatgagga gcgaatgttt aaggaaaacc aaagtttatt   2280

cagtgaggta gcttccttaa aagaacagat gcacaaaagt cgttttctgt ctcaagtagt   2340

tgaagattca gagcccacaa gaaatcagaa ttttacagat ctgttagcag aactacggat   2400

ggcacagaaa gaaaaagaca gtttattgga agacatcaaa agactgaaac aagacaaaca   2460

agctcttgaa gtagacttcg aaaaaatgaa gaaagagagg gaccaagcca aagatcagat   2520

tgcttatgtc acaggtgaga aattatatga aataaaaatt ttagaagaaa cacataaaca   2580

agaaatcagt cgtctgcaaa aaagattaca gtggtatgct gaaaatcagg aacttctgga   2640

taaagatgca cttcggctta gagaagcaaa tgaggaaatt gagaagctca aacttgagat   2700

tgagaaactg aaagctgaat ctgggaatcc atctattcgg cagaagatac gcttaaaaga   2760

taaagcagca gatgccaaaa aaattcagga tctggagcga caagttaagg aaatggaagg   2820

gattctgaag agaagatatc ccaattcttt acctgcttta atattggctg catcagcagc   2880

tggtgataca gtggataaaa atacagtgga atttatggag aaaaggataa aaaagctaga   2940

agctgatctg gagggcaaag atgaagatgc aaagaaaagc cttcgtacca tggaacaaca   3000

gtttcagaaa atgaagattc agtatgaaca aagactagag cagcaggagc agctacttgc   3060

ctgcaaattg aatcaacatg actctcccag aattaaagcc ctagagaagg aacttgatga   3120

catcaaggaa gcccatcaga tcactgtaag aaaccttgaa gccgaaatag acgttcttaa   3180

acatcagaat gctgaattag acgtcaagaa aaatgataaa gatgatgaag attttcagtc   3240

tatagaattc caggtggaac aggctcatgc taaagctaaa ttagtaagac tcaatgaaga   3300

actggctgca aaaaagagag aaatacaaga cctctcaaaa actgtggaga ggcttcagaa   3360

agacagaaga atgatgctat caaatcagaa ctcaaagggc agagaggaaa tgtctgccaa   3420

aagggcaaag aaagatgttt tgcactcaag taaaggaaat gctaactcct tccctggaac   3480

cctggacagc aagctgtacc aaccacatac tttcactgat tcccatgttt cagaagtttt   3540

acaagaaaac tacagattaa aaaatgagct agaaggatta atttcagaga agaatgaact   3600

gaagatgaaa tctgaagcag tgatgaatca atttgaaaac tccatgagaa gggtcaagga   3660

agatactgca gcacacattg catccctcaa agcatctcat cagagagaaa tagagaaact   3720

cctttgccaa aatgcagtag aaaattcttc ttccaaagta gctgaactaa atcgtaaaat   3780

agcaactcaa gaggtactta taagacattt ccaaagtcaa gttaatgagc tgcagagtaa   3840

acaagagtct ctcgtagttt ctgaagttcg agaagaaatt ctacagaaag agattacaaa   3900

actcttagaa gaattgagag aagccaaaga aaaccataca ccagagatga aacatttcgt   3960

gggcttagaa aagaaaatta agcagatgga aatgagacat gcacaaagag aacaggaact   4020

tcaacagata atacagcaaa cacaccaagt agtagaaact gagcaaaaca aagaagttga   4080

aaaatggaaa agactggcac agttaaagaa tcgtgagctg gagaagttcc gcacagaact   4140

agactcaata ttagatgttc tccgagagct gcaccggcaa ggagtggttg tgccagttgc   4200

ttttgcagat gaaatgaatg caccagagta ttaatagaaa ttcagatttc ataatgacct   4260

tattaaaagg cctgaagatg gatgggattg tgccactgtc aggacagctt atgaaaaaca   4320

agtgttccaa tatgtttcca gaaagcaaac aaccaaagca acatttcaaa ataaattgcc   4380

tttaaccaat aagaaaaaaa acatataatg gtgtatttta ctaaaaatca ttaaccagtc   4440

tcattttaag tgatttatgg acagtttcct ttatagcaga gaagggctca cttgtatgct   4500

agaaatagaa agaaaagaaa attgaacata ctccgccaca tttttattga taatgtgagg   4560

tttttaaaat ttttatttta gatccagggg gtacatgtgc ttgttgtaac atgggtgtat   4620

tgaataatgg tgggaattgg gcttctagtg tacccatcat ccaaatatta aacactgtac   4680

ccaacaggta atttttcaac gcttactgcc gctcacactc tttcccctat tggagtcccc   4740

agtgtctgtt atctccatct ttatgtctct gtgtacccat tgtttagctc ctacttttaa   4800

gtgagaatat atgcaatatt ttatttttta tgtctgattt agttcacata ggataatggc   4860

ctccagctct atccatgttg ctgcaaatga catgatttca ttctttttta tagttgcata   4920

atactccatt tatatatctc tctctatata tatctcacgt tttctttatc cagtcaattg   4980

ttggtagata cttaggttgg ttccatgaat ttgctattgt aaatattgct gcaataaaca   5040

tacatgtaca g                                                        5051


<210>  1842
<211>  1327
<212>  PRT
<213>  Homosapiens

<400>  1842

Met Glu Ile Glu Glu Glu Ser Ala Glu Lys Ile Gln Phe Leu Lys Ser 
1               5                   10                  15      


Ser Gly Thr Ser Leu Leu Ser Thr Asp Ser Leu Glu Thr Asn Glu Leu 
            20                  25                  30          


Val Val Ser Glu Leu Asn His Ser Ser Leu Gly Val Gly Leu Asp Thr 
        35                  40                  45              


Leu Glu Glu Gln Glu Glu Lys Glu Gln Phe Phe Ala Arg Leu Glu Lys 
    50                  55                  60                  


Gly Leu Thr Ser Ser Ile Asp Tyr Ser Arg Leu Asn Lys Glu Leu Asp 
65                  70                  75                  80  


Ser Asn Asp Ser Thr His Phe Lys Ala Leu His Ile Asn Gln Ala Asn 
                85                  90                  95      


Ala Glu Leu Thr Asp Asp Glu His Glu Asn Glu Ser Lys His Glu Glu 
            100                 105                 110         


Leu Ala Glu Asn Tyr Ser Asp Asp Phe Glu Asp Glu Tyr Val Gly Ala 
        115                 120                 125             


Pro Leu Thr Thr Lys Asp Glu Glu Met Pro Ser Lys Glu Asn Ser Lys 
    130                 135                 140                 


Ser Glu Lys Ile Ser Val Pro Lys Gln Glu Glu Glu Lys Thr Gly Met 
145                 150                 155                 160 


Leu Ala Asn Val Val Leu Leu Asp Ser Leu Asp Ser Val Ala Glu Val 
                165                 170                 175     


Asn Leu Asp Glu Gln Asp Lys Ile Thr Pro Lys Pro Arg Cys Leu Pro 
            180                 185                 190         


Glu Met Thr Glu Asn Glu Met Thr Gly Thr Gly Val Ser Tyr Gly Gln 
        195                 200                 205             


Ser Ser Ser Asp Val Glu Ala Leu His Gln Ala Tyr Cys His Ile Ala 
    210                 215                 220                 


His Ser Leu Gly Asp Glu Asp Lys Gln Lys Ile Glu Ser Asn Thr Val 
225                 230                 235                 240 


Glu Asp Ile Lys Ser Ser Val Lys Gly His Pro Gln Glu Asn Glu Glu 
                245                 250                 255     


Asn Ser Lys Asn Ile Ser Thr Met Glu Ser Asp Leu Pro Thr Val Glu 
            260                 265                 270         


Glu Leu Met Lys Pro Ile Arg Ile Asp Ser Phe Gly Ile Ser Gly Phe 
        275                 280                 285             


Asp Leu Gln Pro Val Ser Ser Glu Lys Val Ala Glu Arg Lys Glu Thr 
    290                 295                 300                 


Glu Phe Phe Ser Ser Leu Pro Leu Lys Met Asn Pro Asn Ile Leu Ser 
305                 310                 315                 320 


Gln Asp Ser Gln His Val Asn Leu Phe Phe Asp Lys Asn Asp Glu Asn 
                325                 330                 335     


Val Ile Leu Gln Lys Thr Thr Asn Glu Ser Met Glu Asn Ser Cys Pro 
            340                 345                 350         


Gln Val Thr Glu Val Thr Ala Thr Glu Glu His Val Asp Lys Met Tyr 
        355                 360                 365             


Leu Asn Ile Leu Arg Lys Lys Ile Thr Val Asn Ser Ser Ser Leu Ser 
    370                 375                 380                 


Gln Asp Asp Lys Ile Asn Lys Thr Tyr Arg Ser Gln Leu Ser Ser Glu 
385                 390                 395                 400 


Glu Glu Gly Ala Val Met Gly Lys Gln Val Pro Tyr Lys Lys Ala Arg 
                405                 410                 415     


Ser Ala Pro Pro Leu Leu Lys Arg Lys Pro Gln Ser Gly Leu Tyr Ala 
            420                 425                 430         


Ser Val Arg Ser Ser Gly Tyr Gly Lys Pro Ser Ser Pro Leu Lys Met 
        435                 440                 445             


Phe Ser Thr Leu Glu Lys Lys Thr Ser Glu Asp Ile Ile Lys Ser Lys 
    450                 455                 460                 


Asn Leu Arg Ser Ile Ser Thr Ser Asn Gln Pro Arg Lys Lys Glu Ile 
465                 470                 475                 480 


Leu Ser Gly Thr Lys Leu Ile Lys Pro Ala Ala Leu Asp Lys Pro Ala 
                485                 490                 495     


His Lys Thr Glu Ser Cys Leu Ser Thr Arg Lys Lys Ser Glu Asn Pro 
            500                 505                 510         


Thr Glu Thr Asp Ser Cys Ile Gln Phe Gln Thr Asp Ser Leu Gly Tyr 
        515                 520                 525             


Cys Gly Glu Asn Lys Glu Lys Lys Leu Leu Met Phe Lys Arg Val Gln 
    530                 535                 540                 


Glu Ala Glu Asp Lys Trp Arg Gly Ala Gln Ala Leu Ile Glu Gln Ile 
545                 550                 555                 560 


Lys Ala Thr Phe Ser Glu Lys Glu Lys Glu Leu Glu Asn Lys Leu Glu 
                565                 570                 575     


Glu Leu Lys Lys Gln Gln Glu Lys Glu Leu Phe Lys Leu Asn Gln Asp 
            580                 585                 590         


Asn Tyr Ile Leu Gln Ala Lys Leu Ser Ser Phe Glu Glu Thr Asn Lys 
        595                 600                 605             


Lys Gln Arg Trp Leu His Phe Gly Glu Ala Ala Asp Pro Val Thr Gly 
    610                 615                 620                 


Glu Lys Leu Lys Gln Ile Gln Lys Glu Ile Gln Glu Gln Glu Thr Leu 
625                 630                 635                 640 


Leu Gln Gly Tyr Gln Gln Glu Asn Glu Arg Leu Tyr Asn Gln Val Lys 
                645                 650                 655     


Asp Leu Gln Glu Gln Asn Lys Lys Asn Glu Glu Arg Met Phe Lys Glu 
            660                 665                 670         


Asn Gln Ser Leu Phe Ser Glu Val Ala Ser Leu Lys Glu Gln Met His 
        675                 680                 685             


Lys Ser Arg Phe Leu Ser Gln Val Val Glu Asp Ser Glu Pro Thr Arg 
    690                 695                 700                 


Asn Gln Asn Phe Thr Asp Leu Leu Ala Glu Leu Arg Met Ala Gln Lys 
705                 710                 715                 720 


Glu Lys Asp Ser Leu Leu Glu Asp Ile Lys Arg Leu Lys Gln Asp Lys 
                725                 730                 735     


Gln Ala Leu Glu Val Asp Phe Glu Lys Met Lys Lys Glu Arg Asp Gln 
            740                 745                 750         


Ala Lys Asp Gln Ile Ala Tyr Val Thr Gly Glu Lys Leu Tyr Glu Ile 
        755                 760                 765             


Lys Ile Leu Glu Glu Thr His Lys Gln Glu Ile Ser Arg Leu Gln Lys 
    770                 775                 780                 


Arg Leu Gln Trp Tyr Ala Glu Asn Gln Glu Leu Leu Asp Lys Asp Ala 
785                 790                 795                 800 


Leu Arg Leu Arg Glu Ala Asn Glu Glu Ile Glu Lys Leu Lys Leu Glu 
                805                 810                 815     


Ile Glu Lys Leu Lys Ala Glu Ser Gly Asn Pro Ser Ile Arg Gln Lys 
            820                 825                 830         


Ile Arg Leu Lys Asp Lys Ala Ala Asp Ala Lys Lys Ile Gln Asp Leu 
        835                 840                 845             


Glu Arg Gln Val Lys Glu Met Glu Gly Ile Leu Lys Arg Arg Tyr Pro 
    850                 855                 860                 


Asn Ser Leu Pro Ala Leu Ile Leu Ala Ala Ser Ala Ala Gly Asp Thr 
865                 870                 875                 880 


Val Asp Lys Asn Thr Val Glu Phe Met Glu Lys Arg Ile Lys Lys Leu 
                885                 890                 895     


Glu Ala Asp Leu Glu Gly Lys Asp Glu Asp Ala Lys Lys Ser Leu Arg 
            900                 905                 910         


Thr Met Glu Gln Gln Phe Gln Lys Met Lys Ile Gln Tyr Glu Gln Arg 
        915                 920                 925             


Leu Glu Gln Gln Glu Gln Leu Leu Ala Cys Lys Leu Asn Gln His Asp 
    930                 935                 940                 


Ser Pro Arg Ile Lys Ala Leu Glu Lys Glu Leu Asp Asp Ile Lys Glu 
945                 950                 955                 960 


Ala His Gln Ile Thr Val Arg Asn Leu Glu Ala Glu Ile Asp Val Leu 
                965                 970                 975     


Lys His Gln Asn Ala Glu Leu Asp Val Lys Lys Asn Asp Lys Asp Asp 
            980                 985                 990         


Glu Asp Phe Gln Ser Ile Glu Phe  Gln Val Glu Gln Ala  His Ala Lys 
        995                 1000                 1005             


Ala Lys  Leu Val Arg Leu Asn  Glu Glu Leu Ala Ala  Lys Lys Arg 
    1010                 1015                 1020             


Glu Ile  Gln Asp Leu Ser Lys  Thr Val Glu Arg Leu  Gln Lys Asp 
    1025                 1030                 1035             


Arg Arg  Met Met Leu Ser Asn  Gln Asn Ser Lys Gly  Arg Glu Glu 
    1040                 1045                 1050             


Met Ser  Ala Lys Arg Ala Lys  Lys Asp Val Leu His  Ser Ser Lys 
    1055                 1060                 1065             


Gly Asn  Ala Asn Ser Phe Pro  Gly Thr Leu Asp Ser  Lys Leu Tyr 
    1070                 1075                 1080             


Gln Pro  His Thr Phe Thr Asp  Ser His Val Ser Glu  Val Leu Gln 
    1085                 1090                 1095             


Glu Asn  Tyr Arg Leu Lys Asn  Glu Leu Glu Gly Leu  Ile Ser Glu 
    1100                 1105                 1110             


Lys Asn  Glu Leu Lys Met Lys  Ser Glu Ala Val Met  Asn Gln Phe 
    1115                 1120                 1125             


Glu Asn  Ser Met Arg Arg Val  Lys Glu Asp Thr Ala  Ala His Ile 
    1130                 1135                 1140             


Ala Ser  Leu Lys Ala Ser His  Gln Arg Glu Ile Glu  Lys Leu Leu 
    1145                 1150                 1155             


Cys Gln  Asn Ala Val Glu Asn  Ser Ser Ser Lys Val  Ala Glu Leu 
    1160                 1165                 1170             


Asn Arg  Lys Ile Ala Thr Gln  Glu Val Leu Ile Arg  His Phe Gln 
    1175                 1180                 1185             


Ser Gln  Val Asn Glu Leu Gln  Ser Lys Gln Glu Ser  Leu Val Val 
    1190                 1195                 1200             


Ser Glu  Val Arg Glu Glu Ile  Leu Gln Lys Glu Ile  Thr Lys Leu 
    1205                 1210                 1215             


Leu Glu  Glu Leu Arg Glu Ala  Lys Glu Asn His Thr  Pro Glu Met 
    1220                 1225                 1230             


Lys His  Phe Val Gly Leu Glu  Lys Lys Ile Lys Gln  Met Glu Met 
    1235                 1240                 1245             


Arg His  Ala Gln Arg Glu Gln  Glu Leu Gln Gln Ile  Ile Gln Gln 
    1250                 1255                 1260             


Thr His  Gln Val Val Glu Thr  Glu Gln Asn Lys Glu  Val Glu Lys 
    1265                 1270                 1275             


Trp Lys  Arg Leu Ala Gln Leu  Lys Asn Arg Glu Leu  Glu Lys Phe 
    1280                 1285                 1290             


Arg Thr  Glu Leu Asp Ser Ile  Leu Asp Val Leu Arg  Glu Leu His 
    1295                 1300                 1305             


Arg Gln  Gly Val Val Val Pro  Val Ala Phe Ala Asp  Glu Met Asn 
    1310                 1315                 1320             


Ala Pro  Glu Tyr 
    1325         


<210>  1843
<211>  3995
<212>  DNA
<213>  Homosapiens

<400>  1843
cgaattttca aagaacatat tttccgttca cccccgctgg tcttttactg ccatcaatac     60

actgttcttg gtgcaaatac ttcagcctct ttattcaaag tatgttttat gtttttgcca    120

aatatgatct ctaattgaaa gtttattttt ggttttggat gaatctgcgg agcttaagtt    180

gtgagaagaa agggggaaca agacacaatg aaagaaaagt ccaaaaatgc tgcgcggact    240

aggagggaga aggaaaacag tgaattttat gaactggcta aattactgcc tttgccctcg    300

gctatcacct cgcagctgga caaagcatcc ataatcagac tcacgaccag ctatctcaaa    360

atgagagtgg tgttcccaga agggctcggc gaggcgtggg gccactcaag tcggaccagc    420

cccctggaca acgttggccg agaactgggc tcccatctgc tccagaccct ggatggcttc    480

atcttcgtgg tagccccaga tgggaagatc atgtacatct cagagacagc ctcagtccac    540

ttgggtcttt ctcaggtaga gctgaccgga aacagcattt atgaatacat tcacccggca    600

gaccacgacg agatgacggc ggtgctcacc gcccatcaac cctaccactc tcacttcgtg    660

caggagtatg agatcgagcg ctccttcttc ctgaggatga agtgcgtctt ggccaagcgt    720

aacgccggcc tcacctgtgg cggctacaag gtcatccact gcagcggcta cttgaagatc    780

cgccagtaca gcctggacat gtcccccttc gacggctgct accaaaacgt gggcctggtg    840

gccgtgggcc actcgctgcc tcccagcgcc gtcacggaga tcaagctaca cagcaatatg    900

tttatgttcc gcgccagcct ggacatgaag ctcatctttc tggactccag ggtggcggag    960

ctgacggggt acgaacctca ggacctgatt gagaagactc tgtaccacca tgtgcacggc   1020

tgcgacacct tccacctgcg ctgcgcgcac catttgctgc tggtgaaggg acaggtgacc   1080

accaagtact acaggttcct ggcgaaacac ggcggctggg tatgggtgca gagctacgcg   1140

accatcgtgc acaacagtcg ctcctccagg ccacactgta tcgtcagcgt caactatgtc   1200

ctcacagaca cagaatacaa agggctgcag ctctccctgg atcagatctc agcctccaaa   1260

ccagccttct cctataccag cagctccacc cccaccatga ctgacaacag aaagggggcc   1320

aaatcccggc tctccagctc aaagtcaaaa tccaggactt ccccataccc tcagtattcg   1380

ggatttcaca cagaaagatc ggaatctgat catgacagcc agtggggcgg aagtcccttg   1440

accgacacgg cctctccgca gcttctggac cccgccgata ggcctggctc ccagcacgac   1500

gcatcgtgcg cctacagaca gttttcggac cgcagctctc tctgctatgg ctttgcgctt   1560

gaccactcga ggctggtgga agagaggcat ttccataccc aggcctgtga aggaggccga   1620

tgtgaggcag gcaggtactt cctgggaacg ccgcaggccg ggagggagcc ctggtggggc   1680

tctcgcgcag ccttgcccct gacaaaggcc tccccagaaa gcagagaagc ctatgaaaac   1740

agcatgcctc acatcgcttc agtccacagg atccatgggc gaggtcattg ggatgaagat   1800

agtgtggtca gttctccaga ccctgggtcg gccagtgaat caggtgaccg atatcgtact   1860

gagcagtatc aaagtagccc acatgaaccc agcaaaattg aaactcttat aagagccact   1920

cagcaaatga ttaaagaaga agagaacaga ttacagctaa ggaaagcccc ctcagaccaa   1980

ctggcttcca ttaatggggc tgggaaaaaa cactccctgt gttttgcaaa ctaccaacag   2040

cccccaccaa caggtgaagt ctgccatggc tctgctcttg ccaacacttc accatgtgac   2100

catatccagc agagagaggg aaaaatgttg agcccccatg aaaatgacta tgacaacagt   2160

cccaccgcac tatctcggat aagtagtccc aattcggatc gcatttcaaa atccagtttg   2220

atcctagcta aagactatct gcattcggat atatctcctc atcagacagc aggagaccac   2280

cctactgtct ctccaaactg ctttggctct caccggcagt attttgacaa gcatgcttac   2340

acattaactg gatatgccct ggagcactta tatgacagcg aaaccattag aaactattcc   2400

ttgggctgta atggctcaca ctttgatgta acttcccatc tgaggatgca accagaccca   2460

gcacaaggac acaagggaac atctgttata ataaccaacg gaagctgatg ttttgctgaa   2520

atattttgtt ctttaaggat ctctgaaaca tatttatagt ttaatacccc attaccagca   2580

tttactatgc cacagattgt tagagagtat aacttaagtt actgggtatt tgatacgtgt   2640

tcctataaaa tcaaagaaaa catagcacta gcattcaggg ttatacacag aaaagggagc   2700

taaattgaat acacaaattt cccctctaat tatatgggaa ccagaataga taaattttga   2760

cttgaaaaat attcatgtag atcaagtgtg catatatact acatgagagg actgatgaat   2820

gacaacattg cattgtgact atccagtgat cctcaaacac acaaactatt acttacaaac   2880

tgcggtatac attttacata tggaaatata ggctatgtaa tgtaaataca tcaaaaatgg   2940

gtaattttct ttgactctgt cacactaaac ttcttaacga aatttccatt cccaaaataa   3000

ctgagaaaga gagagataca tcttataaac tgacttcttt gtggtttcaa atcagccagc   3060

tcatttggtt caggcataaa ttagagaaat ggttctggat atggtgcaaa aatgagtttt   3120

cacctggtat ccattataaa caatcaggaa gaggtaattt ttcaccttgc ttttcagtta   3180

gacaaggacc aggattgcac tgacatggcg ctgagggttt ttctaagtaa gaacactgag   3240

atattgggac acacatcaaa aacctggagt gctcaattgg aagtagttct atgaatatgg   3300

aaaggccaga ggcagagtga aataaaatgc tatctcaaag tttaacacaa tttaagggct   3360

cagcataagt aaacaacata tttggggttt gcttgtaaaa ccaactaaat aaaaaattca   3420

aaccaattca cccagaaaaa agaccaatag gtgcaaaaat aaaaggaaaa ccagtgaagt   3480

gccacatgac agcagtgtta agtgtttgaa aacgtttcaa agcacatatg tgccaatgtg   3540

acaacatgtg gaaagcctca ggagagagtc taagataaaa gcttaggctg atagacaagt   3600

agttaagagc taagagcagt actctgaagg aataggcaaa atgtttattt tccttattgt   3660

ttgtaaacaa caaacttggt cttacatctg tgtggtatag tagaaaggcc agctgactag   3720

atctctggat tctaattttg gccctacctg taacttaatt ttgtgaccac agttgtacca   3780

ttcaccgtgc ctgggctcta gtttcctggt ttgtaaggca gccccagcgt tcatgttctg   3840

tgatagagca gaactgaact tattacctaa ttaactctct gctatgagtt gtcaagactg   3900

atcattctgt tttttctgta cacagaagtt tagatgcttt gtgacttaag caggtgtgtg   3960

ggctccttta ggcaggttac agttaacttt ctaga                              3995


<210>  1844
<211>  766
<212>  PRT
<213>  Homosapiens

<400>  1844

Met Lys Glu Lys Ser Lys Asn Ala Ala Arg Thr Arg Arg Glu Lys Glu 
1               5                   10                  15      


Asn Ser Glu Phe Tyr Glu Leu Ala Lys Leu Leu Pro Leu Pro Ser Ala 
            20                  25                  30          


Ile Thr Ser Gln Leu Asp Lys Ala Ser Ile Ile Arg Leu Thr Thr Ser 
        35                  40                  45              


Tyr Leu Lys Met Arg Val Val Phe Pro Glu Gly Leu Gly Glu Ala Trp 
    50                  55                  60                  


Gly His Ser Ser Arg Thr Ser Pro Leu Asp Asn Val Gly Arg Glu Leu 
65                  70                  75                  80  


Gly Ser His Leu Leu Gln Thr Leu Asp Gly Phe Ile Phe Val Val Ala 
                85                  90                  95      


Pro Asp Gly Lys Ile Met Tyr Ile Ser Glu Thr Ala Ser Val His Leu 
            100                 105                 110         


Gly Leu Ser Gln Val Glu Leu Thr Gly Asn Ser Ile Tyr Glu Tyr Ile 
        115                 120                 125             


His Pro Ala Asp His Asp Glu Met Thr Ala Val Leu Thr Ala His Gln 
    130                 135                 140                 


Pro Tyr His Ser His Phe Val Gln Glu Tyr Glu Ile Glu Arg Ser Phe 
145                 150                 155                 160 


Phe Leu Arg Met Lys Cys Val Leu Ala Lys Arg Asn Ala Gly Leu Thr 
                165                 170                 175     


Cys Gly Gly Tyr Lys Val Ile His Cys Ser Gly Tyr Leu Lys Ile Arg 
            180                 185                 190         


Gln Tyr Ser Leu Asp Met Ser Pro Phe Asp Gly Cys Tyr Gln Asn Val 
        195                 200                 205             


Gly Leu Val Ala Val Gly His Ser Leu Pro Pro Ser Ala Val Thr Glu 
    210                 215                 220                 


Ile Lys Leu His Ser Asn Met Phe Met Phe Arg Ala Ser Leu Asp Met 
225                 230                 235                 240 


Lys Leu Ile Phe Leu Asp Ser Arg Val Ala Glu Leu Thr Gly Tyr Glu 
                245                 250                 255     


Pro Gln Asp Leu Ile Glu Lys Thr Leu Tyr His His Val His Gly Cys 
            260                 265                 270         


Asp Thr Phe His Leu Arg Cys Ala His His Leu Leu Leu Val Lys Gly 
        275                 280                 285             


Gln Val Thr Thr Lys Tyr Tyr Arg Phe Leu Ala Lys His Gly Gly Trp 
    290                 295                 300                 


Val Trp Val Gln Ser Tyr Ala Thr Ile Val His Asn Ser Arg Ser Ser 
305                 310                 315                 320 


Arg Pro His Cys Ile Val Ser Val Asn Tyr Val Leu Thr Asp Thr Glu 
                325                 330                 335     


Tyr Lys Gly Leu Gln Leu Ser Leu Asp Gln Ile Ser Ala Ser Lys Pro 
            340                 345                 350         


Ala Phe Ser Tyr Thr Ser Ser Ser Thr Pro Thr Met Thr Asp Asn Arg 
        355                 360                 365             


Lys Gly Ala Lys Ser Arg Leu Ser Ser Ser Lys Ser Lys Ser Arg Thr 
    370                 375                 380                 


Ser Pro Tyr Pro Gln Tyr Ser Gly Phe His Thr Glu Arg Ser Glu Ser 
385                 390                 395                 400 


Asp His Asp Ser Gln Trp Gly Gly Ser Pro Leu Thr Asp Thr Ala Ser 
                405                 410                 415     


Pro Gln Leu Leu Asp Pro Ala Asp Arg Pro Gly Ser Gln His Asp Ala 
            420                 425                 430         


Ser Cys Ala Tyr Arg Gln Phe Ser Asp Arg Ser Ser Leu Cys Tyr Gly 
        435                 440                 445             


Phe Ala Leu Asp His Ser Arg Leu Val Glu Glu Arg His Phe His Thr 
    450                 455                 460                 


Gln Ala Cys Glu Gly Gly Arg Cys Glu Ala Gly Arg Tyr Phe Leu Gly 
465                 470                 475                 480 


Thr Pro Gln Ala Gly Arg Glu Pro Trp Trp Gly Ser Arg Ala Ala Leu 
                485                 490                 495     


Pro Leu Thr Lys Ala Ser Pro Glu Ser Arg Glu Ala Tyr Glu Asn Ser 
            500                 505                 510         


Met Pro His Ile Ala Ser Val His Arg Ile His Gly Arg Gly His Trp 
        515                 520                 525             


Asp Glu Asp Ser Val Val Ser Ser Pro Asp Pro Gly Ser Ala Ser Glu 
    530                 535                 540                 


Ser Gly Asp Arg Tyr Arg Thr Glu Gln Tyr Gln Ser Ser Pro His Glu 
545                 550                 555                 560 


Pro Ser Lys Ile Glu Thr Leu Ile Arg Ala Thr Gln Gln Met Ile Lys 
                565                 570                 575     


Glu Glu Glu Asn Arg Leu Gln Leu Arg Lys Ala Pro Ser Asp Gln Leu 
            580                 585                 590         


Ala Ser Ile Asn Gly Ala Gly Lys Lys His Ser Leu Cys Phe Ala Asn 
        595                 600                 605             


Tyr Gln Gln Pro Pro Pro Thr Gly Glu Val Cys His Gly Ser Ala Leu 
    610                 615                 620                 


Ala Asn Thr Ser Pro Cys Asp His Ile Gln Gln Arg Glu Gly Lys Met 
625                 630                 635                 640 


Leu Ser Pro His Glu Asn Asp Tyr Asp Asn Ser Pro Thr Ala Leu Ser 
                645                 650                 655     


Arg Ile Ser Ser Pro Asn Ser Asp Arg Ile Ser Lys Ser Ser Leu Ile 
            660                 665                 670         


Leu Ala Lys Asp Tyr Leu His Ser Asp Ile Ser Pro His Gln Thr Ala 
        675                 680                 685             


Gly Asp His Pro Thr Val Ser Pro Asn Cys Phe Gly Ser His Arg Gln 
    690                 695                 700                 


Tyr Phe Asp Lys His Ala Tyr Thr Leu Thr Gly Tyr Ala Leu Glu His 
705                 710                 715                 720 


Leu Tyr Asp Ser Glu Thr Ile Arg Asn Tyr Ser Leu Gly Cys Asn Gly 
                725                 730                 735     


Ser His Phe Asp Val Thr Ser His Leu Arg Met Gln Pro Asp Pro Ala 
            740                 745                 750         


Gln Gly His Lys Gly Thr Ser Val Ile Ile Thr Asn Gly Ser 
        755                 760                 765     


<210>  1845
<211>  7598
<212>  DNA
<213>  Homosapiens

<400>  1845
gtaggccggc gccagctcca ctctgtccct cctcgccggg tctgtgcgtc tttgcgtctg     60

tctgtctgac tgatggtcct cacacgcggt tccctgtgac tgggcgcgac cccggcaagc    120

gcggcttgga gggcggacgg ggcgcggcga tacagctgcc cgctcgcatc tttggccctg    180

cgctcagctc ctcacccggc gtgggaagtt aaagtaaaac cgaaagggaa gaaggcgcgg    240

tggcaggagc tgacagagtg atgggaaacg cgtgagccag gccgagagtt tcaggtttct    300

tgctgtatgg atcactgatt gaataataga tggctttacc tcgtctcaca ggagccttgc    360

gttccttttc aaatgtcacc aagcaagata attataatga agaagtggct gacttaaaga    420

taaagcgatc taaacttcat gaacaagttt tagatttggg cctgacatgg aagaagataa    480

taaaattttt gaatgaaaaa ctggagaaga gtaaaatgca aagtataaat gaagacttaa    540

aagatatatt acatgctgca aagcagatag ttggaactga taatgggaga gaagcaattg    600

aaagtggggc tgcatttctc ttcatgacat ttcacttgaa ggactctgtt ggtcacaagg    660

aaacaaaggc tatcaaacag atgtttggcc cctttccttc atcatctgcc actgcagctt    720

gtaatgctac taatcgaatt atttctcatt ttagtcaaga tgatcttact gctcttgtgc    780

agatgacaga aaaagaacat ggcgataggg ttttttttgg taaaaattta gcattttcat    840

ttgacatgca tgatttggac cactttgacg aactgccaat aaatggtgaa actcagaaaa    900

ctataagcct agattataag aagtttctga atgaacatct ccaggaggct tgcaccccag    960

aactcaagcc tgtggaaaaa acaaatggct cctttttgtg gtgtgaagtt gaaaagtacc   1020

taaattcaac tttgaaggaa atgactgaag tgccaagagt agaagatctt tgctgtactt   1080

tatatgatat gcttgcttct attaaaagtg gtgatgaact tcaggatgag ctatttgaac   1140

tgctgggacc tgaaggactt gaacttattg agaaactcct ccagaacaga attacaattg   1200

tggatagatt tcttaattct tcaaatgatc ataggtttca ggctcttcaa gacaattgta   1260

aaaaaatttt aggagaaaat gctaaaccca attatggttg tcaagtcact attcagtctg   1320

aacaagaaaa gcagttaatg aaacaatatc gacgtgaaga aaaaagaatt gccagacgag   1380

aaaaaaaggc tggagaagat ttagaagttt cagaaggact tatgtgcttt gatcctaagg   1440

aattgcggat acaaagagaa caggcacttc tgaatgctag aagtgttcca attctgagca   1500

ggcagagaga tgcagacgtt gaaaaaatac attatcccca tgtgtatgat tcccaggctg   1560

aagccatgaa aacatcagca tttattgctg gtgcaaagat gattttgcca gaaggaatcc   1620

aaagagagaa taacaagctt tatgaagaag taaggattcc ctacagcgaa ccaatgccac   1680

tcagctttga ggaaaagcca gtttatatcc aagacttaga tgagatcgga cagctggctt   1740

ttaaaggaat gaagagactc aatagaatcc agtcaatagt gtttgagact gcctacaaca   1800

ccaatgagaa catgctgatt tgtgccccta caggagctgg aaaaaccaac attgcaatgc   1860

tgacagtctt gcatgaaatt cgccaacatt ttcaacaagg tgttatcaaa aagaatgaat   1920

ttaagattgt atatgttgct ccaatgaaag ccttggcagc tgaaatgaca gattacttca   1980

gcagacgtct agagccacta ggcatcattg tgaaagaatt gactggtgac atgcagttgt   2040

ccaaaagtga aattttacga actcagatgc ttgtgaccac accagaaaaa tgggatgtag   2100

tgacaagaaa gagtgttggg gatgtagctc tttcccagat tgtaaggctc cttattcttg   2160

atgaagttca tttgctgcat gaagatagag gaccagtatt agaaagcata gttgcccgta   2220

ctttacggca ggtggaatcc acacagagta tgataaggat tctcggactg tctgcaactt   2280

tacctaacta cctcgatgtt gccacatttt tacatgttaa tccatacatt ggacttttct   2340

tctttgatgg ccgttttcga ccagtacctc ttggacagac atttttgggg attaaatgtg   2400

caaataagat gcagcagttg aataacatgg atgaagtatg ttatgaaaat gttttgaagc   2460

aagtaaaggc tggacaccag gtgatggtgt ttgtacatgc tcgaaatgcc actgtaagaa   2520

cagctatgtc tctaatagaa agagcaaaaa attgtggcca tattcccttc ttttttccta   2580

cccaaggaca tgactatgta cttgcagaaa aacaggtaca aaggtcgaga aataagcaag   2640

tacgagaatt attcccagat ggttttagta ttcatcatgc aggaatgctt cggcaggaca   2700

gaaatttagt tgaaaacttg ttttctaatg ggcatatcaa agtcctagtg tgtacagcta   2760

cgttagcctg gggtgtcaat cttcccgccc atgctgttat tattaaggga acacaaatat   2820

atgctgcaaa aagaggctcc tttgttgacc ttggaatttt agatgtcatg cagatatttg   2880

gtcgagctgg acgaccacaa tttgacaaat ttggggaagg aataattata acaacgcatg   2940

ataaactcag ccattacctc actttgctca ctcaacgaaa cccaattgag agtcagtttc   3000

tggaaagcct tgcagataac ctaaatgcag agattgctct gggaacagtt actaatgtgg   3060

aagaagcagt gaagtggata agttacactt atctttatgt acggatgaga gcaaatccat   3120

tagcatatgg catcagtcac aaggcttatc agattgaccc aacattaaga aagcatcgag   3180

aacagttggt cattgaagtt ggacgaaaac tagacaaagc tcagatgatt cgttttgagg   3240

agcgaactgg atatttttcc tcaactgatt tgggtagaac tgccagccat tactatatta   3300

aatacaacac cattgagacc tttaatgaac tctttgatgc tcacaaaaca gaaggtgata   3360

tctttgccat agtctccaaa gctgaagaat ttgatcaaat taaggtcaga gaagaggaaa   3420

tagaggagtt agatacctta ttaagcaatt tttgtgaact ctccactcct ggaggtgtag   3480

agaatagtta tgggaaaata aacatcttac ttcaaactta tatcagccga ggagaaatgg   3540

acagtttctc ccttatatca gattctgcat atgttgcaca gaatgcagct agaattgtcc   3600

gtgctctttt tgaaattgct ctgaggaaac gttggcctac catgacctac aggctcctga   3660

atcttagtaa agtcattgac aagaggcttt ggggttgggc tagccctttg agacaatttt   3720

caatcctacc accacacatc ctaacaagat tagaagaaaa aaagcttact gtggataagc   3780

tgaaagacat gaggaaagat gaaataggtc acattttaca tcatgtgaat attggactga   3840

aggtcaaaca atgtgttcat cagattcctt ctgttatgat ggaagcatcc attcagccta   3900

tcacaaggac tgtcctccga gtgacactca gcatctatgc tgatttcact tggaatgatc   3960

aggtacatgg gacagtagga gaaccttggt ggatttgggt agaagatcct acaaatgatc   4020

atatttatca ttcagagtat tttctagctc taaaaaaaca agtcattagt aaagaagccc   4080

aactactggt atttacaatc cctatttttg agcctttgcc ttcccaatac tacatccgag   4140

cagtgtctga tagatggttg ggtgctgagg cagtatgtat tatcaacttt caacatctaa   4200

ttctaccaga gagacatcct cctcatacag aattactgga tcttcagcct ttaccaatca   4260

cagctttggg atgtaaagca tatgaagccc tgtacaactt cagccacttt aaccctgtac   4320

agacacaaat atttcataca ttgtatcaca cggattgtaa tgtcctactt ggagcaccta   4380

ctggatcggg aaagactgtt gcagctgaat tagccatttt cagagtcttc aacaaatacc   4440

ctacttcaaa ggcggtatat attgcacccc taaaagccct agtacgtgaa agaatggatg   4500

attggaaagt tagaatagaa gaaaaacttg gtaaaaaagt tattgaacta acaggggatg   4560

tgactcctga tatgaaatcc attgccaagg ctgaccttat cgtcactacg ccagagaagt   4620

gggatggagt cagcagaagc tggcaaaata ggaactatgt tcagcaagtc actattctca   4680

tcatagatga gatccatctg cttggggagg aaagaggccc tgttctagag gtcattgtat   4740

ctcgaacaaa ttttatctca tcacacacag aaaagcctgt tagaatagtt ggactatcta   4800

ctgcattagc taatgccaga gaccttgctg attggctcaa tattaagcag atgggcttgt   4860

ttaacttccg accatcagta cgcccagttc cactggaagt tcacattcaa ggctttccag   4920

gtcaacatta ctgtcctcgt atggctagta tgaacaagcc tgcatttcag gcaattagaa   4980

gccattctcc agccaaacct gttttgatat ttgtctcatc aagacgtcaa actcgtctta   5040

ctgctttgga attgatcgcc ttcctggcta ctgaagaaga tccaaagcag tggttaaaca   5100

tggatgaaag agagatggag aacatcattg caacagtaag agattccaac ctcaagctga   5160

cccttgcttt cgggatagga atgcatcatg ctggactaca tgagagggac cgaaaaacag   5220

tagaggaact atttgtaaac tgtaaagttc aggttcttat tgctacaagc acattagcct   5280

ggggtgtaaa ctttccagct catttagtaa ttattaaggg aacagaatac tatgatggaa   5340

aaacaagacg ttatgtggat tttcccatta cagatgtcct ccagatgatg gggcgtgctg   5400

ggaggccgca gttcgatgac caaggcaaag ctgtaattct agttcatgac ataaagaaag   5460

acttttataa aaaatttctt tatgaacctt tcccagtaga atcaagttta ttaggagtgc   5520

tctctgacca cttaaatgca gagattgctg gtggtacaat tacatctaag caagatgcat   5580

tggattatat cacctggact tactttttcc gacgtcttat catgaatccc agctattaca   5640

atttgggtga tgtgagccat gattctgtga acaagtttct gtcccatctg attgagaagt   5700

ccctgattga attggaactt tcctactgta ttgaaattgg agaggataat cgcagcattg   5760

aacctctaac ttatggccga attgcctcct attactattt gaagcatcaa acagttaaaa   5820

tgttcaagga ccgcttgaag cctgaatgca gtactgaaga actgctttca attctaagtg   5880

atgcagaaga atatacagat ttgccagtga gacacaatga agatcatatg aatagtgaac   5940

tggcaaaatg tcttcccatt gaatcaaatc ctcattcatt tgacagccct cacaccaaag   6000

cacatctcct gctacaggca catctcagcc gagccatgct accctgccca gattatgaca   6060

ctgataccaa aacagtcttg gaccaagctc tcagagtatg tcaggcaatg ctggacgtgg   6120

ctgcaaacca gggctggctg gtgactgtcc tgaatatcac caacctgatt cagatggtga   6180

tccagggtcg gtggttaaag gactcttctc ttcttacact accaaacata gaaaaccatc   6240

atcttcacct tttcaagaaa tggaagccga ttatgaaggg cccacatgct aggggtcgga   6300

cctccatcga gtcccttcct gaactgatcc atgcctgtgg agggaaagac catgtattta   6360

gctccatggt agaaagtgag ctacatgctg caaaaacgaa acaggcatgg aatttcttat   6420

ctcacttgcc agtgataaat gttggcataa gtgttaaagg ctcgtgggat gacttagttg   6480

aaggacataa tgaactctct gtctcaactc tgactgcaga caaacgagat gacaacaaat   6540

ggatcaaatt gcatgctgac caagagtatg tgcttcaagt gagcttgcag agagtccact   6600

ttgggttcca caagggaaag ccagagagct gtgcagttac tcctcgattt cccaaatcaa   6660

aagacgaagg atggtttttg atattaggag aagtggataa gagagaactt attgctttga   6720

aaagagtagg atatattcga aatcatcatg ttgcttccct ttctttttat acccctgaaa   6780

tacctggaag gtatatctac acattatatt tcatgagtga ctgctacctt ggcctggacc   6840

agcagtatga catctatctc aacgttacac aagcgagtct ttctgcacag gtcaacacca   6900

aggtctctga ttccctgact gacctggcat taaagtaact tgacctgaac aatccatttg   6960

aaaggagtgg ctaagaattc tctctgttca gtcatctaga caaatcgaat tacttgatgt   7020

ttgccttgaa agaatcaact tctaacctca accatccagg aaattgacag tggctgcagt   7080

attgactcca gtgacataaa gttaaccaca gtggcctttt aacaaatgtt gccttttata   7140

atgttatctt tatgagtttc ttgatatgta agatgaaaaa gcatttagaa taatctttta   7200

atttgtgtat atttgggatg atatttagga gctatcaatc aaattttaca tctcacaatg   7260

tactgtttac atggatattg gctgcttttt ttaaggaaaa ccacattgag atgtgacaag   7320

tgttaggact tgtcacagat ttctaactct gccgcataaa ctataaatct gtaaggtggt   7380

acacagcgtg tcttgttagc aaaatttata ctttgatatg atcacatgta gaagtagctt   7440

caagaatttc ttgtagtcat aaatgtttaa taatatatga tgtaaaatta tattatggag   7500

cctaatgatg ataacaaaga aaacaatata ctgatcttag aaaatgtaga catggttaac   7560

tgggaaataa aatatagagt ggcacttcaa gaaaaaaa                           7598


<210>  1846
<211>  2202
<212>  PRT
<213>  Homosapiens

<400>  1846

Met Ala Leu Pro Arg Leu Thr Gly Ala Leu Arg Ser Phe Ser Asn Val 
1               5                   10                  15      


Thr Lys Gln Asp Asn Tyr Asn Glu Glu Val Ala Asp Leu Lys Ile Lys 
            20                  25                  30          


Arg Ser Lys Leu His Glu Gln Val Leu Asp Leu Gly Leu Thr Trp Lys 
        35                  40                  45              


Lys Ile Ile Lys Phe Leu Asn Glu Lys Leu Glu Lys Ser Lys Met Gln 
    50                  55                  60                  


Ser Ile Asn Glu Asp Leu Lys Asp Ile Leu His Ala Ala Lys Gln Ile 
65                  70                  75                  80  


Val Gly Thr Asp Asn Gly Arg Glu Ala Ile Glu Ser Gly Ala Ala Phe 
                85                  90                  95      


Leu Phe Met Thr Phe His Leu Lys Asp Ser Val Gly His Lys Glu Thr 
            100                 105                 110         


Lys Ala Ile Lys Gln Met Phe Gly Pro Phe Pro Ser Ser Ser Ala Thr 
        115                 120                 125             


Ala Ala Cys Asn Ala Thr Asn Arg Ile Ile Ser His Phe Ser Gln Asp 
    130                 135                 140                 


Asp Leu Thr Ala Leu Val Gln Met Thr Glu Lys Glu His Gly Asp Arg 
145                 150                 155                 160 


Val Phe Phe Gly Lys Asn Leu Ala Phe Ser Phe Asp Met His Asp Leu 
                165                 170                 175     


Asp His Phe Asp Glu Leu Pro Ile Asn Gly Glu Thr Gln Lys Thr Ile 
            180                 185                 190         


Ser Leu Asp Tyr Lys Lys Phe Leu Asn Glu His Leu Gln Glu Ala Cys 
        195                 200                 205             


Thr Pro Glu Leu Lys Pro Val Glu Lys Thr Asn Gly Ser Phe Leu Trp 
    210                 215                 220                 


Cys Glu Val Glu Lys Tyr Leu Asn Ser Thr Leu Lys Glu Met Thr Glu 
225                 230                 235                 240 


Val Pro Arg Val Glu Asp Leu Cys Cys Thr Leu Tyr Asp Met Leu Ala 
                245                 250                 255     


Ser Ile Lys Ser Gly Asp Glu Leu Gln Asp Glu Leu Phe Glu Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Leu Glu Leu Ile Glu Lys Leu Leu Gln Asn Arg Ile 
        275                 280                 285             


Thr Ile Val Asp Arg Phe Leu Asn Ser Ser Asn Asp His Arg Phe Gln 
    290                 295                 300                 


Ala Leu Gln Asp Asn Cys Lys Lys Ile Leu Gly Glu Asn Ala Lys Pro 
305                 310                 315                 320 


Asn Tyr Gly Cys Gln Val Thr Ile Gln Ser Glu Gln Glu Lys Gln Leu 
                325                 330                 335     


Met Lys Gln Tyr Arg Arg Glu Glu Lys Arg Ile Ala Arg Arg Glu Lys 
            340                 345                 350         


Lys Ala Gly Glu Asp Leu Glu Val Ser Glu Gly Leu Met Cys Phe Asp 
        355                 360                 365             


Pro Lys Glu Leu Arg Ile Gln Arg Glu Gln Ala Leu Leu Asn Ala Arg 
    370                 375                 380                 


Ser Val Pro Ile Leu Ser Arg Gln Arg Asp Ala Asp Val Glu Lys Ile 
385                 390                 395                 400 


His Tyr Pro His Val Tyr Asp Ser Gln Ala Glu Ala Met Lys Thr Ser 
                405                 410                 415     


Ala Phe Ile Ala Gly Ala Lys Met Ile Leu Pro Glu Gly Ile Gln Arg 
            420                 425                 430         


Glu Asn Asn Lys Leu Tyr Glu Glu Val Arg Ile Pro Tyr Ser Glu Pro 
        435                 440                 445             


Met Pro Leu Ser Phe Glu Glu Lys Pro Val Tyr Ile Gln Asp Leu Asp 
    450                 455                 460                 


Glu Ile Gly Gln Leu Ala Phe Lys Gly Met Lys Arg Leu Asn Arg Ile 
465                 470                 475                 480 


Gln Ser Ile Val Phe Glu Thr Ala Tyr Asn Thr Asn Glu Asn Met Leu 
                485                 490                 495     


Ile Cys Ala Pro Thr Gly Ala Gly Lys Thr Asn Ile Ala Met Leu Thr 
            500                 505                 510         


Val Leu His Glu Ile Arg Gln His Phe Gln Gln Gly Val Ile Lys Lys 
        515                 520                 525             


Asn Glu Phe Lys Ile Val Tyr Val Ala Pro Met Lys Ala Leu Ala Ala 
    530                 535                 540                 


Glu Met Thr Asp Tyr Phe Ser Arg Arg Leu Glu Pro Leu Gly Ile Ile 
545                 550                 555                 560 


Val Lys Glu Leu Thr Gly Asp Met Gln Leu Ser Lys Ser Glu Ile Leu 
                565                 570                 575     


Arg Thr Gln Met Leu Val Thr Thr Pro Glu Lys Trp Asp Val Val Thr 
            580                 585                 590         


Arg Lys Ser Val Gly Asp Val Ala Leu Ser Gln Ile Val Arg Leu Leu 
        595                 600                 605             


Ile Leu Asp Glu Val His Leu Leu His Glu Asp Arg Gly Pro Val Leu 
    610                 615                 620                 


Glu Ser Ile Val Ala Arg Thr Leu Arg Gln Val Glu Ser Thr Gln Ser 
625                 630                 635                 640 


Met Ile Arg Ile Leu Gly Leu Ser Ala Thr Leu Pro Asn Tyr Leu Asp 
                645                 650                 655     


Val Ala Thr Phe Leu His Val Asn Pro Tyr Ile Gly Leu Phe Phe Phe 
            660                 665                 670         


Asp Gly Arg Phe Arg Pro Val Pro Leu Gly Gln Thr Phe Leu Gly Ile 
        675                 680                 685             


Lys Cys Ala Asn Lys Met Gln Gln Leu Asn Asn Met Asp Glu Val Cys 
    690                 695                 700                 


Tyr Glu Asn Val Leu Lys Gln Val Lys Ala Gly His Gln Val Met Val 
705                 710                 715                 720 


Phe Val His Ala Arg Asn Ala Thr Val Arg Thr Ala Met Ser Leu Ile 
                725                 730                 735     


Glu Arg Ala Lys Asn Cys Gly His Ile Pro Phe Phe Phe Pro Thr Gln 
            740                 745                 750         


Gly His Asp Tyr Val Leu Ala Glu Lys Gln Val Gln Arg Ser Arg Asn 
        755                 760                 765             


Lys Gln Val Arg Glu Leu Phe Pro Asp Gly Phe Ser Ile His His Ala 
    770                 775                 780                 


Gly Met Leu Arg Gln Asp Arg Asn Leu Val Glu Asn Leu Phe Ser Asn 
785                 790                 795                 800 


Gly His Ile Lys Val Leu Val Cys Thr Ala Thr Leu Ala Trp Gly Val 
                805                 810                 815     


Asn Leu Pro Ala His Ala Val Ile Ile Lys Gly Thr Gln Ile Tyr Ala 
            820                 825                 830         


Ala Lys Arg Gly Ser Phe Val Asp Leu Gly Ile Leu Asp Val Met Gln 
        835                 840                 845             


Ile Phe Gly Arg Ala Gly Arg Pro Gln Phe Asp Lys Phe Gly Glu Gly 
    850                 855                 860                 


Ile Ile Ile Thr Thr His Asp Lys Leu Ser His Tyr Leu Thr Leu Leu 
865                 870                 875                 880 


Thr Gln Arg Asn Pro Ile Glu Ser Gln Phe Leu Glu Ser Leu Ala Asp 
                885                 890                 895     


Asn Leu Asn Ala Glu Ile Ala Leu Gly Thr Val Thr Asn Val Glu Glu 
            900                 905                 910         


Ala Val Lys Trp Ile Ser Tyr Thr Tyr Leu Tyr Val Arg Met Arg Ala 
        915                 920                 925             


Asn Pro Leu Ala Tyr Gly Ile Ser His Lys Ala Tyr Gln Ile Asp Pro 
    930                 935                 940                 


Thr Leu Arg Lys His Arg Glu Gln Leu Val Ile Glu Val Gly Arg Lys 
945                 950                 955                 960 


Leu Asp Lys Ala Gln Met Ile Arg Phe Glu Glu Arg Thr Gly Tyr Phe 
                965                 970                 975     


Ser Ser Thr Asp Leu Gly Arg Thr Ala Ser His Tyr Tyr Ile Lys Tyr 
            980                 985                 990         


Asn Thr Ile Glu Thr Phe Asn Glu  Leu Phe Asp Ala His  Lys Thr Glu 
        995                 1000                 1005             


Gly Asp  Ile Phe Ala Ile Val  Ser Lys Ala Glu Glu  Phe Asp Gln 
    1010                 1015                 1020             


Ile Lys  Val Arg Glu Glu Glu  Ile Glu Glu Leu Asp  Thr Leu Leu 
    1025                 1030                 1035             


Ser Asn  Phe Cys Glu Leu Ser  Thr Pro Gly Gly Val  Glu Asn Ser 
    1040                 1045                 1050             


Tyr Gly  Lys Ile Asn Ile Leu  Leu Gln Thr Tyr Ile  Ser Arg Gly 
    1055                 1060                 1065             


Glu Met  Asp Ser Phe Ser Leu  Ile Ser Asp Ser Ala  Tyr Val Ala 
    1070                 1075                 1080             


Gln Asn  Ala Ala Arg Ile Val  Arg Ala Leu Phe Glu  Ile Ala Leu 
    1085                 1090                 1095             


Arg Lys  Arg Trp Pro Thr Met  Thr Tyr Arg Leu Leu  Asn Leu Ser 
    1100                 1105                 1110             


Lys Val  Ile Asp Lys Arg Leu  Trp Gly Trp Ala Ser  Pro Leu Arg 
    1115                 1120                 1125             


Gln Phe  Ser Ile Leu Pro Pro  His Ile Leu Thr Arg  Leu Glu Glu 
    1130                 1135                 1140             


Lys Lys  Leu Thr Val Asp Lys  Leu Lys Asp Met Arg  Lys Asp Glu 
    1145                 1150                 1155             


Ile Gly  His Ile Leu His His  Val Asn Ile Gly Leu  Lys Val Lys 
    1160                 1165                 1170             


Gln Cys  Val His Gln Ile Pro  Ser Val Met Met Glu  Ala Ser Ile 
    1175                 1180                 1185             


Gln Pro  Ile Thr Arg Thr Val  Leu Arg Val Thr Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Ala Asp  Phe Thr Trp Asn Asp  Gln Val His Gly Thr  Val Gly Glu 
    1205                 1210                 1215             


Pro Trp  Trp Ile Trp Val Glu  Asp Pro Thr Asn Asp  His Ile Tyr 
    1220                 1225                 1230             


His Ser  Glu Tyr Phe Leu Ala  Leu Lys Lys Gln Val  Ile Ser Lys 
    1235                 1240                 1245             


Glu Ala  Gln Leu Leu Val Phe  Thr Ile Pro Ile Phe  Glu Pro Leu 
    1250                 1255                 1260             


Pro Ser  Gln Tyr Tyr Ile Arg  Ala Val Ser Asp Arg  Trp Leu Gly 
    1265                 1270                 1275             


Ala Glu  Ala Val Cys Ile Ile  Asn Phe Gln His Leu  Ile Leu Pro 
    1280                 1285                 1290             


Glu Arg  His Pro Pro His Thr  Glu Leu Leu Asp Leu  Gln Pro Leu 
    1295                 1300                 1305             


Pro Ile  Thr Ala Leu Gly Cys  Lys Ala Tyr Glu Ala  Leu Tyr Asn 
    1310                 1315                 1320             


Phe Ser  His Phe Asn Pro Val  Gln Thr Gln Ile Phe  His Thr Leu 
    1325                 1330                 1335             


Tyr His  Thr Asp Cys Asn Val  Leu Leu Gly Ala Pro  Thr Gly Ser 
    1340                 1345                 1350             


Gly Lys  Thr Val Ala Ala Glu  Leu Ala Ile Phe Arg  Val Phe Asn 
    1355                 1360                 1365             


Lys Tyr  Pro Thr Ser Lys Ala  Val Tyr Ile Ala Pro  Leu Lys Ala 
    1370                 1375                 1380             


Leu Val  Arg Glu Arg Met Asp  Asp Trp Lys Val Arg  Ile Glu Glu 
    1385                 1390                 1395             


Lys Leu  Gly Lys Lys Val Ile  Glu Leu Thr Gly Asp  Val Thr Pro 
    1400                 1405                 1410             


Asp Met  Lys Ser Ile Ala Lys  Ala Asp Leu Ile Val  Thr Thr Pro 
    1415                 1420                 1425             


Glu Lys  Trp Asp Gly Val Ser  Arg Ser Trp Gln Asn  Arg Asn Tyr 
    1430                 1435                 1440             


Val Gln  Gln Val Thr Ile Leu  Ile Ile Asp Glu Ile  His Leu Leu 
    1445                 1450                 1455             


Gly Glu  Glu Arg Gly Pro Val  Leu Glu Val Ile Val  Ser Arg Thr 
    1460                 1465                 1470             


Asn Phe  Ile Ser Ser His Thr  Glu Lys Pro Val Arg  Ile Val Gly 
    1475                 1480                 1485             


Leu Ser  Thr Ala Leu Ala Asn  Ala Arg Asp Leu Ala  Asp Trp Leu 
    1490                 1495                 1500             


Asn Ile  Lys Gln Met Gly Leu  Phe Asn Phe Arg Pro  Ser Val Arg 
    1505                 1510                 1515             


Pro Val  Pro Leu Glu Val His  Ile Gln Gly Phe Pro  Gly Gln His 
    1520                 1525                 1530             


Tyr Cys  Pro Arg Met Ala Ser  Met Asn Lys Pro Ala  Phe Gln Ala 
    1535                 1540                 1545             


Ile Arg  Ser His Ser Pro Ala  Lys Pro Val Leu Ile  Phe Val Ser 
    1550                 1555                 1560             


Ser Arg  Arg Gln Thr Arg Leu  Thr Ala Leu Glu Leu  Ile Ala Phe 
    1565                 1570                 1575             


Leu Ala  Thr Glu Glu Asp Pro  Lys Gln Trp Leu Asn  Met Asp Glu 
    1580                 1585                 1590             


Arg Glu  Met Glu Asn Ile Ile  Ala Thr Val Arg Asp  Ser Asn Leu 
    1595                 1600                 1605             


Lys Leu  Thr Leu Ala Phe Gly  Ile Gly Met His His  Ala Gly Leu 
    1610                 1615                 1620             


His Glu  Arg Asp Arg Lys Thr  Val Glu Glu Leu Phe  Val Asn Cys 
    1625                 1630                 1635             


Lys Val  Gln Val Leu Ile Ala  Thr Ser Thr Leu Ala  Trp Gly Val 
    1640                 1645                 1650             


Asn Phe  Pro Ala His Leu Val  Ile Ile Lys Gly Thr  Glu Tyr Tyr 
    1655                 1660                 1665             


Asp Gly  Lys Thr Arg Arg Tyr  Val Asp Phe Pro Ile  Thr Asp Val 
    1670                 1675                 1680             


Leu Gln  Met Met Gly Arg Ala  Gly Arg Pro Gln Phe  Asp Asp Gln 
    1685                 1690                 1695             


Gly Lys  Ala Val Ile Leu Val  His Asp Ile Lys Lys  Asp Phe Tyr 
    1700                 1705                 1710             


Lys Lys  Phe Leu Tyr Glu Pro  Phe Pro Val Glu Ser  Ser Leu Leu 
    1715                 1720                 1725             


Gly Val  Leu Ser Asp His Leu  Asn Ala Glu Ile Ala  Gly Gly Thr 
    1730                 1735                 1740             


Ile Thr  Ser Lys Gln Asp Ala  Leu Asp Tyr Ile Thr  Trp Thr Tyr 
    1745                 1750                 1755             


Phe Phe  Arg Arg Leu Ile Met  Asn Pro Ser Tyr Tyr  Asn Leu Gly 
    1760                 1765                 1770             


Asp Val  Ser His Asp Ser Val  Asn Lys Phe Leu Ser  His Leu Ile 
    1775                 1780                 1785             


Glu Lys  Ser Leu Ile Glu Leu  Glu Leu Ser Tyr Cys  Ile Glu Ile 
    1790                 1795                 1800             


Gly Glu  Asp Asn Arg Ser Ile  Glu Pro Leu Thr Tyr  Gly Arg Ile 
    1805                 1810                 1815             


Ala Ser  Tyr Tyr Tyr Leu Lys  His Gln Thr Val Lys  Met Phe Lys 
    1820                 1825                 1830             


Asp Arg  Leu Lys Pro Glu Cys  Ser Thr Glu Glu Leu  Leu Ser Ile 
    1835                 1840                 1845             


Leu Ser  Asp Ala Glu Glu Tyr  Thr Asp Leu Pro Val  Arg His Asn 
    1850                 1855                 1860             


Glu Asp  His Met Asn Ser Glu  Leu Ala Lys Cys Leu  Pro Ile Glu 
    1865                 1870                 1875             


Ser Asn  Pro His Ser Phe Asp  Ser Pro His Thr Lys  Ala His Leu 
    1880                 1885                 1890             


Leu Leu  Gln Ala His Leu Ser  Arg Ala Met Leu Pro  Cys Pro Asp 
    1895                 1900                 1905             


Tyr Asp  Thr Asp Thr Lys Thr  Val Leu Asp Gln Ala  Leu Arg Val 
    1910                 1915                 1920             


Cys Gln  Ala Met Leu Asp Val  Ala Ala Asn Gln Gly  Trp Leu Val 
    1925                 1930                 1935             


Thr Val  Leu Asn Ile Thr Asn  Leu Ile Gln Met Val  Ile Gln Gly 
    1940                 1945                 1950             


Arg Trp  Leu Lys Asp Ser Ser  Leu Leu Thr Leu Pro  Asn Ile Glu 
    1955                 1960                 1965             


Asn His  His Leu His Leu Phe  Lys Lys Trp Lys Pro  Ile Met Lys 
    1970                 1975                 1980             


Gly Pro  His Ala Arg Gly Arg  Thr Ser Ile Glu Ser  Leu Pro Glu 
    1985                 1990                 1995             


Leu Ile  His Ala Cys Gly Gly  Lys Asp His Val Phe  Ser Ser Met 
    2000                 2005                 2010             


Val Glu  Ser Glu Leu His Ala  Ala Lys Thr Lys Gln  Ala Trp Asn 
    2015                 2020                 2025             


Phe Leu  Ser His Leu Pro Val  Ile Asn Val Gly Ile  Ser Val Lys 
    2030                 2035                 2040             


Gly Ser  Trp Asp Asp Leu Val  Glu Gly His Asn Glu  Leu Ser Val 
    2045                 2050                 2055             


Ser Thr  Leu Thr Ala Asp Lys  Arg Asp Asp Asn Lys  Trp Ile Lys 
    2060                 2065                 2070             


Leu His  Ala Asp Gln Glu Tyr  Val Leu Gln Val Ser  Leu Gln Arg 
    2075                 2080                 2085             


Val His  Phe Gly Phe His Lys  Gly Lys Pro Glu Ser  Cys Ala Val 
    2090                 2095                 2100             


Thr Pro  Arg Phe Pro Lys Ser  Lys Asp Glu Gly Trp  Phe Leu Ile 
    2105                 2110                 2115             


Leu Gly  Glu Val Asp Lys Arg  Glu Leu Ile Ala Leu  Lys Arg Val 
    2120                 2125                 2130             


Gly Tyr  Ile Arg Asn His His  Val Ala Ser Leu Ser  Phe Tyr Thr 
    2135                 2140                 2145             


Pro Glu  Ile Pro Gly Arg Tyr  Ile Tyr Thr Leu Tyr  Phe Met Ser 
    2150                 2155                 2160             


Asp Cys  Tyr Leu Gly Leu Asp  Gln Gln Tyr Asp Ile  Tyr Leu Asn 
    2165                 2170                 2175             


Val Thr  Gln Ala Ser Leu Ser  Ala Gln Val Asn Thr  Lys Val Ser 
    2180                 2185                 2190             


Asp Ser  Leu Thr Asp Leu Ala  Leu Lys 
    2195                 2200         


<210>  1847
<211>  3470
<212>  DNA
<213>  Homosapiens

<400>  1847
gtaggccggc gccagctcca ctctgtccct cctcgccggg tctgtgcgtc tttgcgtctg     60

tctgtctgac tgatggtcct cacacgcggt tccctgtgac tgggcgcgac cccggcaagc    120

gcggcttgga gggcggacgg ggcgcggcga tacagctgcc cgctcgcatc tttggccctg    180

cgctcagctc ctcacccggc gtgggaagtt aaagtaaaac cgaaagggaa gaaggcgcgg    240

tggcaggagc tgacagagtg atgggaaacg cgtgagccag gccgagagtt tcaggtttct    300

tgctgtatgg atcactgatt gaataataga tggctttacc tcgtctcaca ggagccttgc    360

gttccttttc aaatgtcacc aagcaagata attataatga agaagtggct gacttaaaga    420

taaagcgatc taaacttcat gaacaagttt tagatttggg cctgacatgg aagaagataa    480

taaaattttt gaatgaaaaa ctggagaaga gtaaaatgca aagtataaat gaagacttaa    540

aagatatatt acatgctgca aagcagatag aagtgaattg tccattccag aagaggaggc    600

tggatggaaa agaggaggat gagaagatga gcagagcttc tgacagattc agaggactaa    660

gatgacaaaa atgactaaaa tggacaaaag aagaaataga aaatctgaat atttgactat    720

taaaggaatt taatctgtaa ttaaaaacct taagtacaaa gaaatctata tgctatgatg    780

gctttaatgg agaatgtcat aatgtcattt aaaaaggtat gagagtacta ttgtagatta    840

aaagaggtta aaggcatata ataatcaaaa tgtaatgtat gatccttgat tgactcttga    900

atcagaaaaa aattacgtat ttttggggcc gttggagaaa tctgaatatg ggctggacat    960

cattaggtaa tattagatct caggtgtgat aatgttgtgg ctatgtaaga ggatatccta   1020

aatctcagga gaagcatact gcagtatata tagtggtatc tcatgaagat taaaatgtac   1080

tgtcaaatgt gtcagcaaaa gaaatacaca tgatgtgtgt gtgtgatcaa gtgtttataa   1140

tgagtggatt aataaatatg agaagatagg gtgatttgtt gtaaagtaat aaaggtttaa   1200

aaattacatg attcagtaga gaaaaagcat tttatgaata tctaacatta cttatgataa   1260

aaaatctcag caaactagga atagaagggg attttgttaa tctgataagc tgtagctata   1320

aaaaacttgg agaaaacata cttaatgcta caaagttaga agcttccctg aggtacggaa   1380

ttagacacaa atgcctgtta ccacttctgt ttctcactgt attaaaaatc cttgctaaca   1440

taatatggca agaaaaagta agggcataaa gactggaaaa aaaaactttt ccatttttca   1500

catgactgta cctgtagaaa atgaatttaa caaggttaat ataaaaatca attttatttc   1560

tacttactag aagcacatta aaaattacac ttatctttat gtaacgtaat acattttacc   1620

ttaaatttta aaattttaat ttattttacg tttacaaaag catcataaac atcaaatacg   1680

taggagtaaa tttaacaaaa aataagcaag acttcatgga aaactaaaat attgagagaa   1740

tttaaagaag atctaaataa acagagggat ataccaagaa ttggaagact cactattata   1800

atgatatatt ttttacccaa attgatctgt agattcagtg ctatcccagg cacagtctta   1860

tgtttgaggg tgtgtgtgtg tgtgtgtgtg tatgtgtgca tgtgtgtgtg tggaaattga   1920

caagggtaat atgaaagtta tatggaaatt caaaggcaaa gagcagcctg gttaactttg   1980

aaaaataaaa agggagaact tactctagta gatcttaaaa cttattataa agataagtat   2040

acagtgtggt gttggtccaa gaataggcaa atggactagt atgacagaat atagcccaga   2100

aacaaaccta cggatagaaa tatacttgat ttataatgaa ggccaaacaa tagtgagaca   2160

aggctatttt ttcagtatat ggtgctgggt caactgcata tacagatgaa aaaaagtacc   2220

tattttacaa ataattttaa acagcctaca gaattaagca tgatacacaa aacaatacat   2280

cttctaaaag atgtaaaaga gtgtcttcag gatctttgta tgtgcgaaaa tttatcaaac   2340

agagaacaaa aagtacaaag ggaatgatta agttggactg tagtaaaatt aataccttct   2400

atttattaag agtaaaaagg caaaacatgg agtgggagaa tatagcttca agatatataa   2460

ccaaaaagag agcttttatc caggttaaat acgagctcct acaaatcaat aaggaaagga   2520

cagataatcc tatatgaaca tgagtaagag ctttgaacaa ggacttcaca agagatagtt   2580

gaccagtaaa catgaaaagg gcttcagctt cattggtagt caaggatatg ccactgcatg   2640

cccattagaa tggttaaaat gtaaaagact gacataccta ttgttaggat caagaatgtg   2700

aactagaatt tttgtctact gctgctagag tttacaattg gtacaaccac tttgagtaac   2760

tgtttgacag tgtctactat tacctactgt ggttggacaa gtgaaatttt aaatcttagg   2820

acataaatat ccaataaaaa tgcttgtaca tacatgtata tcaaaaatag gtgcattcat   2880

tgcaacatta tttgtgatag ccttaatgta gaaacaaccc agttcattgt taaaaagctt   2940

aagttgtagt atgtagactg ccttatagca gtaacggatt acagctatgt ataacattgt   3000

aagtgaatct tataatgttg acaaaagaag ccatacaaca catattatga ttccattaat   3060

atgaaactga aaactaggca tgaccagtct ctggttttag aagtcaggat agtggctgct   3120

tttgaggaag gaggtagtga ctaggagtga atatgaggga ggtttctggg gagctgataa   3180

tgttctgatt cttgaagtag ttaaccagat tacacaggtg tgttcgtttt ttgataattc   3240

tttgaactgt atgtgtactg tatattttct tgttatattc aataaaaaga attactatga   3300

tttttatatt acatagatta aataagaagt atttcagatt gataagtaac acatgcttgt   3360

gtatttattt agcttaaggt ttggctatca tggtgagaac tcctatgtac cctgctcagg   3420

tcctggtaaa cagtatcata agtataataa attggtgttt ttcattctca              3470


<210>  1848
<211>  111
<212>  PRT
<213>  Homosapiens

<400>  1848

Met Ala Leu Pro Arg Leu Thr Gly Ala Leu Arg Ser Phe Ser Asn Val 
1               5                   10                  15      


Thr Lys Gln Asp Asn Tyr Asn Glu Glu Val Ala Asp Leu Lys Ile Lys 
            20                  25                  30          


Arg Ser Lys Leu His Glu Gln Val Leu Asp Leu Gly Leu Thr Trp Lys 
        35                  40                  45              


Lys Ile Ile Lys Phe Leu Asn Glu Lys Leu Glu Lys Ser Lys Met Gln 
    50                  55                  60                  


Ser Ile Asn Glu Asp Leu Lys Asp Ile Leu His Ala Ala Lys Gln Ile 
65                  70                  75                  80  


Glu Val Asn Cys Pro Phe Gln Lys Arg Arg Leu Asp Gly Lys Glu Glu 
                85                  90                  95      


Asp Glu Lys Met Ser Arg Ala Ser Asp Arg Phe Arg Gly Leu Arg 
            100                 105                 110     


<210>  1849
<211>  4614
<212>  DNA
<213>  Homosapiens

<400>  1849
ggggctgcag gaaaggcgcg agcagaggcg gcggcgggtg tactgtaggt ggtcggtccg     60

gcagcagccc ggcccccgga cgcaggacgt ggccccaggc agccctcgca gctcagtgct    120

ctagccgggg caagcccgcg tctccgcctg ctggacgggc ccaggcgaga tgtagggctc    180

tgggcgcgga ggccgccggt ggggcggctg atcgcggagg atcgcggagg gcgcgccgag    240

gatggagaga gcgatggagc aactcaaccg cctgacgcgc tcgctgcgcc acgcgcgcac    300

cgtggagttg cccgaggata atgaaactgc tgtttataca ttaatgccaa tggttatggc    360

tgatcaacac aggtctgttt ctgaactact atcaaattca aaatttgatg tcaattatgc    420

attcggacgt gtgaaaagaa gcttgcttca cattgcagca aattgtggat cggtggaatg    480

cttggttttg ctgttaaaga aaggagcaaa tcctaactat caagatattt caggctgtac    540

accccttcat ttggcagcaa gaaatgggca gaagaaatgt atgagtaaat tattagaata    600

tagcgctgat gtcaacattt gtaataatga aggccttaca gcaatacatt ggctggctgt    660

gaatgggcgg acagaactac tccatgacct tgtgcagcat gtcagtgatg ttgatgttga    720

ggatgccatg gggcagacag cactgcatgt tgcctgccag aacggtcaca agacgacagt    780

gcagtgcttg ctagacagtg gtgctgatat taacaggcca aatgtatcag gagcaactcc    840

attgtacttt gcttgcagtc atggtcagag agatacagca cagatcctac tattacgagg    900

agccaaatat ctgccagata aaaatggagt aactcctctg gatttatgtg tacagggtgg    960

atatggagag acttgtgaag tattaattca atatcacccg aggctttttc agactattat   1020

tcaaatgaca cagaatgaag acctccgaga aaacatgtta cggcaagttc tggagcattt   1080

gtctcagcaa agtgaaagcc agtacctaaa gattctaaca agccttgctg aagttgctac   1140

aacaaatggt cataaactgc ttagcctctc tagcaattat gatgctcaaa tgaagagcct   1200

tttaaggatt gtgagaatgt tttgtcacgt ctttcgaatt ggtccatcct cccccagtaa   1260

tggaattgat atgggctaca atgggaataa aactccaaga agccaggtgt tcaagcctct   1320

ggaattgctt tggcactcgt tagatgaatg gctagtttta acagccacag aattgatgaa   1380

aaacaaaaga gactcaacag agatcacttc tattttactg aaacaaaaag gccaagatca   1440

agatgctgct tccattcctc catttgaacc tccaggacct gggagctatg aaaatctgtc   1500

cactggcaca agggaatcta aaccagatgc tcttgcaggg agacaggaag ccagtgcaga   1560

ttgtcaggat gttatttcta tgacagctaa ccggctaagt gctgtcattc aagcttttta   1620

catgtgctgt tcttgtcaga tgcctccggg aatgacttca cctcgtttca ttgaatttgt   1680

ctgcaaacat gatgaagttt taaaatgctt tgttaataga aatcccaaaa ttatatttga   1740

ccactttcac tttctccttg aatgtcctga gttgatgtca agattcatgc atatcataaa   1800

agcacagcct tttaaagatc gctgtgaatg gttctatgaa catttgcatt caggacagcc   1860

agattcagat atggtgcaca ggccagtgaa tgaaaatgat atcctgctgg ttcacagaga   1920

ttctattttt aggagtagct gtgaagttgt gtcaaaagca aattgtgcaa agctaaagca   1980

agggattgct gtacggttcc atggagaaga aggcatgggt caaggtgttg tgcgtgagtg   2040

gtttgatatt ctgtccaatg agatagtcaa tcctgattat gcattgttta cccagtcagc   2100

tgatggaaca acttttcagc ctaatagcaa ctcttatgta aatcctgatc acttgaacta   2160

ttttcggttt gctgggcaga tcttgggatt agcgttgaac cacaggcagc tggtcaatat   2220

ttacttcaca cgatccttct acaagcacat tcttggtatt cctgtaaatt accaagatgt   2280

ggcatccatt gatccagaat atgcgaaaaa tttgcaatgg attttagata atgatataag   2340

tgatctgggt ctagaactaa ctttttctgt tgagactgat gtgtttggag caatggaaga   2400

ggtgcctttg aaacctgggg gtgggagtat tcttgtgaca caaaataata aagcggagta   2460

cgtccagctt gttactgaac ttcgaatgac aagagccatt cagcctcaga tcaatgcttt   2520

tttacagggc tttcatatgt tcattccacc ctccctcata cagctttttg atgaatatga   2580

attggagcta ctgctttctg gcatgccaga aattgatgtg agtgattgga taaaaaatac   2640

agaatacaca agtggctatg aaagagaaga tccagttatt cagtggttct gggaagttgt   2700

agaagacatt actcaagagg agagagttct tctcttacag tttgttacgg gcagttccag   2760

ggtcccacat ggtgggtttg ctaatatcat gggtggaagt ggattgcaaa actttacaat   2820

cgctgctgtg ccatatactc caaatctttt accaacttca agcacatgca tcaacatgct   2880

caagttacct gaatacccaa gtaaagaaat actcaaggac agacttcttg tggcactaca   2940

ttgtggcagc tatggttaca caatggcata atgaagtctg gaaaactcct ctgactactg   3000

atgcacaatt cagaatggca gaagtaattt gggaaaatgt caacaaaaaa gcagcctaaa   3060

tgcaacccat aggcagggct gatgcttcca atttataaag gatcatcagg ttttctgttt   3120

ctctcttttc ccttttatgt tttctctgtt tgtgatacaa ttagaaaata taaaatcaca   3180

gtagatttta ttttttaaaa tgctaactga aagtaataga gactgtcctt tttcataatt   3240

aattttatcc aagattgtat taaggcaaaa tctgattcta cattccacct ctgctatgta   3300

actgccttgt taaaagggtg ttttctccta atttctgata tattatatga ggtcatccag   3360

ctggtgtgtt cttttgcatg taaactgcca tttatatttt agaaaactat tgtatagaat   3420

ggatttagat tgtctataaa gccacaaata cgtattttgc cacagtgtat tctatattgc   3480

aatgattttt ttagcatttt aatattttaa tatatattgt aaaatttaga ctgatgatac   3540

taacagttga tgaaatgaca tataatttat atatgaaagc ttacgctata ttgtatgaat   3600

tatttgcatc tttcagtggc cagttttcca tatgtatata ttatggtctc aatgtttttc   3660

ttacgcctca ttttaattta taatgaaggt aaaattaaaa tgtattttac cacgtttctt   3720

ttcattactt ttatctgtga gctctgacac atctgaaaaa gtaatctgat gtgcaaatta   3780

taatttaaat atgttaattt ttttgcttct taaatttgct tttcatcatt aaaatgtcaa   3840

gttcaagtga tatgtgccta atatcacttg gatgttggtg ggtttttgaa tttttgggtg   3900

gttaatcagt tttattttga aaagacgtac ttgaatagtt acagcatatg tttgaacagg   3960

aagtaggaac atgcatacac gaagaaatgc taacggaagg atttgttatg tttaggatct   4020

tcccttggaa actaaaaata gaatattaat gacattactg tttgtagaat gacatatgca   4080

gattttctca taagcagtca ttgtgtttgc cagtaatgtt tgagagacat gtaagttgaa   4140

agttttgcta aattataaag ctcctttaat tcgttggttt tgattctctt attctcttgt   4200

cttttctaaa tgttaacaaa atatatctta acagattaca tgaaatttag gaattattta   4260

aaagttacca ttagctctaa aattaagatt cggatgcttt atttatagta actgaagcta   4320

ataatgtttt atgttttgat tttttgaaat ttaattgtag aagtcactgc cttctgagtt   4380

ttcaaataga taaccacctt taatattaca ctgcttataa tactaatgtt tacagatatg   4440

tttctgttta taaccatata atacattggc tttgtcatat tagttttttt tgcaagtagt   4500

tatgtaaaag agatagataa taaaatatta aataactgag aaaaaaaaaa aaaaaaaaaa   4560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaagaa aaaaaaaaaa aaaa         4614


<210>  1850
<211>  909
<212>  PRT
<213>  Homosapiens

<400>  1850

Met Glu Arg Ala Met Glu Gln Leu Asn Arg Leu Thr Arg Ser Leu Arg 
1               5                   10                  15      


His Ala Arg Thr Val Glu Leu Pro Glu Asp Asn Glu Thr Ala Val Tyr 
            20                  25                  30          


Thr Leu Met Pro Met Val Met Ala Asp Gln His Arg Ser Val Ser Glu 
        35                  40                  45              


Leu Leu Ser Asn Ser Lys Phe Asp Val Asn Tyr Ala Phe Gly Arg Val 
    50                  55                  60                  


Lys Arg Ser Leu Leu His Ile Ala Ala Asn Cys Gly Ser Val Glu Cys 
65                  70                  75                  80  


Leu Val Leu Leu Leu Lys Lys Gly Ala Asn Pro Asn Tyr Gln Asp Ile 
                85                  90                  95      


Ser Gly Cys Thr Pro Leu His Leu Ala Ala Arg Asn Gly Gln Lys Lys 
            100                 105                 110         


Cys Met Ser Lys Leu Leu Glu Tyr Ser Ala Asp Val Asn Ile Cys Asn 
        115                 120                 125             


Asn Glu Gly Leu Thr Ala Ile His Trp Leu Ala Val Asn Gly Arg Thr 
    130                 135                 140                 


Glu Leu Leu His Asp Leu Val Gln His Val Ser Asp Val Asp Val Glu 
145                 150                 155                 160 


Asp Ala Met Gly Gln Thr Ala Leu His Val Ala Cys Gln Asn Gly His 
                165                 170                 175     


Lys Thr Thr Val Gln Cys Leu Leu Asp Ser Gly Ala Asp Ile Asn Arg 
            180                 185                 190         


Pro Asn Val Ser Gly Ala Thr Pro Leu Tyr Phe Ala Cys Ser His Gly 
        195                 200                 205             


Gln Arg Asp Thr Ala Gln Ile Leu Leu Leu Arg Gly Ala Lys Tyr Leu 
    210                 215                 220                 


Pro Asp Lys Asn Gly Val Thr Pro Leu Asp Leu Cys Val Gln Gly Gly 
225                 230                 235                 240 


Tyr Gly Glu Thr Cys Glu Val Leu Ile Gln Tyr His Pro Arg Leu Phe 
                245                 250                 255     


Gln Thr Ile Ile Gln Met Thr Gln Asn Glu Asp Leu Arg Glu Asn Met 
            260                 265                 270         


Leu Arg Gln Val Leu Glu His Leu Ser Gln Gln Ser Glu Ser Gln Tyr 
        275                 280                 285             


Leu Lys Ile Leu Thr Ser Leu Ala Glu Val Ala Thr Thr Asn Gly His 
    290                 295                 300                 


Lys Leu Leu Ser Leu Ser Ser Asn Tyr Asp Ala Gln Met Lys Ser Leu 
305                 310                 315                 320 


Leu Arg Ile Val Arg Met Phe Cys His Val Phe Arg Ile Gly Pro Ser 
                325                 330                 335     


Ser Pro Ser Asn Gly Ile Asp Met Gly Tyr Asn Gly Asn Lys Thr Pro 
            340                 345                 350         


Arg Ser Gln Val Phe Lys Pro Leu Glu Leu Leu Trp His Ser Leu Asp 
        355                 360                 365             


Glu Trp Leu Val Leu Thr Ala Thr Glu Leu Met Lys Asn Lys Arg Asp 
    370                 375                 380                 


Ser Thr Glu Ile Thr Ser Ile Leu Leu Lys Gln Lys Gly Gln Asp Gln 
385                 390                 395                 400 


Asp Ala Ala Ser Ile Pro Pro Phe Glu Pro Pro Gly Pro Gly Ser Tyr 
                405                 410                 415     


Glu Asn Leu Ser Thr Gly Thr Arg Glu Ser Lys Pro Asp Ala Leu Ala 
            420                 425                 430         


Gly Arg Gln Glu Ala Ser Ala Asp Cys Gln Asp Val Ile Ser Met Thr 
        435                 440                 445             


Ala Asn Arg Leu Ser Ala Val Ile Gln Ala Phe Tyr Met Cys Cys Ser 
    450                 455                 460                 


Cys Gln Met Pro Pro Gly Met Thr Ser Pro Arg Phe Ile Glu Phe Val 
465                 470                 475                 480 


Cys Lys His Asp Glu Val Leu Lys Cys Phe Val Asn Arg Asn Pro Lys 
                485                 490                 495     


Ile Ile Phe Asp His Phe His Phe Leu Leu Glu Cys Pro Glu Leu Met 
            500                 505                 510         


Ser Arg Phe Met His Ile Ile Lys Ala Gln Pro Phe Lys Asp Arg Cys 
        515                 520                 525             


Glu Trp Phe Tyr Glu His Leu His Ser Gly Gln Pro Asp Ser Asp Met 
    530                 535                 540                 


Val His Arg Pro Val Asn Glu Asn Asp Ile Leu Leu Val His Arg Asp 
545                 550                 555                 560 


Ser Ile Phe Arg Ser Ser Cys Glu Val Val Ser Lys Ala Asn Cys Ala 
                565                 570                 575     


Lys Leu Lys Gln Gly Ile Ala Val Arg Phe His Gly Glu Glu Gly Met 
            580                 585                 590         


Gly Gln Gly Val Val Arg Glu Trp Phe Asp Ile Leu Ser Asn Glu Ile 
        595                 600                 605             


Val Asn Pro Asp Tyr Ala Leu Phe Thr Gln Ser Ala Asp Gly Thr Thr 
    610                 615                 620                 


Phe Gln Pro Asn Ser Asn Ser Tyr Val Asn Pro Asp His Leu Asn Tyr 
625                 630                 635                 640 


Phe Arg Phe Ala Gly Gln Ile Leu Gly Leu Ala Leu Asn His Arg Gln 
                645                 650                 655     


Leu Val Asn Ile Tyr Phe Thr Arg Ser Phe Tyr Lys His Ile Leu Gly 
            660                 665                 670         


Ile Pro Val Asn Tyr Gln Asp Val Ala Ser Ile Asp Pro Glu Tyr Ala 
        675                 680                 685             


Lys Asn Leu Gln Trp Ile Leu Asp Asn Asp Ile Ser Asp Leu Gly Leu 
    690                 695                 700                 


Glu Leu Thr Phe Ser Val Glu Thr Asp Val Phe Gly Ala Met Glu Glu 
705                 710                 715                 720 


Val Pro Leu Lys Pro Gly Gly Gly Ser Ile Leu Val Thr Gln Asn Asn 
                725                 730                 735     


Lys Ala Glu Tyr Val Gln Leu Val Thr Glu Leu Arg Met Thr Arg Ala 
            740                 745                 750         


Ile Gln Pro Gln Ile Asn Ala Phe Leu Gln Gly Phe His Met Phe Ile 
        755                 760                 765             


Pro Pro Ser Leu Ile Gln Leu Phe Asp Glu Tyr Glu Leu Glu Leu Leu 
    770                 775                 780                 


Leu Ser Gly Met Pro Glu Ile Asp Val Ser Asp Trp Ile Lys Asn Thr 
785                 790                 795                 800 


Glu Tyr Thr Ser Gly Tyr Glu Arg Glu Asp Pro Val Ile Gln Trp Phe 
                805                 810                 815     


Trp Glu Val Val Glu Asp Ile Thr Gln Glu Glu Arg Val Leu Leu Leu 
            820                 825                 830         


Gln Phe Val Thr Gly Ser Ser Arg Val Pro His Gly Gly Phe Ala Asn 
        835                 840                 845             


Ile Met Gly Gly Ser Gly Leu Gln Asn Phe Thr Ile Ala Ala Val Pro 
    850                 855                 860                 


Tyr Thr Pro Asn Leu Leu Pro Thr Ser Ser Thr Cys Ile Asn Met Leu 
865                 870                 875                 880 


Lys Leu Pro Glu Tyr Pro Ser Lys Glu Ile Leu Lys Asp Arg Leu Leu 
                885                 890                 895     


Val Ala Leu His Cys Gly Ser Tyr Gly Tyr Thr Met Ala 
            900                 905                 


<210>  1851
<211>  5504
<212>  DNA
<213>  Homosapiens

<400>  1851
aattgacaaa gtcacgtgtg ctcagggggc cagaaactgg agagaggaga gaaaaaaatc     60

aaaagaagga aagcacatta gaccatgcga gctaaatttg tgatcgcaca aaatcaagat    120

gttagattga tgcagaagat cactccgttc caaagggaaa gttttcatct cacgagtttg    180

gagctgaggg cccgtggggc aacatggccg aaggcggggc tagcaaaggt ggtggagaag    240

agcccgggaa gctgccggag ccggcagagg aggaatccca ggttttgcgc ggaactggcc    300

actgtaagtg gttcaatgtg cgcatgggat ttggattcat ctccatgata aaccgagagg    360

gaagcccctt ggatattcca gtcgatgtat ttgtacacca aagcaaacta ttcatggaag    420

gatttagaag cctaaaagaa ggagaaccag tggaattcac atttaaaaaa tcttccaaag    480

gccttgagtc aatacgggta acaggacctg gtgggagccc ctgtttagga agtgaaagaa    540

gacccaaagg gaagacacta cagaaaagaa aaccaaaggg agatagatgc tacaactgtg    600

gtggccttga tcatcatgct aaggaatgta gtctacctcc tcagccaaag aagtgccatt    660

actgtcagag catcatgcac atggtggcaa actgcccaca taaaaatgtt gcacagccac    720

ccgcgagttc tcagggaaga caggaagcag aatcccagcc atgcacttca actctccctc    780

gagaagtggg aggcgggcat ggctgtacat caccaccgtt tcctcaggag gctagggcag    840

agatctcaga acggtcaggc aggtcacctc aagaagcttc ctccacgaag tcatctatag    900

caccagaaga gcaaagcaaa aaggggcctt cagttcaaaa aaggaaaaag acataacagg    960

tcttcttcat atgttctttc ctttacccgg ttgcaaagtc tacctcatgc aagtataggg   1020

gaacagtatt tcacaagcag tagctgacct gggattttaa ctactattgg ggaactgtga   1080

attttttaaa cagacaaatc actctaagca aattacattt gagcagggtg tcatgtttta   1140

tgttaattca gagaataaga tactatgtct gtcaatatgt gcatgtgtga gagggagaga   1200

gcctgagtct gtgtgtgtac atgaggattt ttatatagga atgtagacac atatataaag   1260

aggctttgtc tttatatatt tgtgtataga tcaaagcaca caccctctct catataattg   1320

gatatttcca agaattgaaa acccatgtga agcattatag atagttttaa atttaaccca   1380

ctggagtttt cttgaaatac cacttctttt atattatata aaactaaaaa cacgactgtt   1440

accttttgtg tgaaccaaag gatacttcag atctcagagc tgccaattat ggggtactaa   1500

aggtttttaa gacatccagt tctcccgaat ttgggattgc ctctttttct tgaaatctct   1560

ggagtagtaa tttttttccc ccttttttga aggcagtacc ttaacttcat atgcctctga   1620

ctgccataag cttttttgat tctgggataa cataactcca gaaaagacaa tgaatgtgta   1680

atttgggccg atatttcact gttttaaatt ctgtgtttaa ttgtaaaatt agatgcctat   1740

taagagaaat gaaggggagg atcatcttag tggcttgttt tcagtagtat tttaatatca   1800

gcttcttgta accttttcca tgttgtgagg gttgtaaggg attgtgtggc aacagcagct   1860

tcccttggct aactcaatct tctacccatt gcttagagca gggagccctc cttatttact   1920

actgaagacc ttagagaact ccaattgttt ggcatatatt tttggtggtg gtttttattc   1980

ctcctggaga gttatctaat ttgtttctaa aacaaacaag cagcaaagaa atgaattaaa   2040

tactggggtt gagaattaaa attaagtgga tgttcacagt tgcccaatat atatgacctg   2100

caaatgatac gaaaaagtgc agcatttagt ggcagttaac aagagtgaca agcctggggc   2160

agaggtacca aacctctccc accagagagc tagaagtatt ttatacagta actttgatct   2220

tatggaagtg accttcaatg cttattctga agtaacctat atggtggata caggatgaac   2280

attcagtgcc agggagaatc ttctcaggtt ggttctcgtt agagtgataa actggctagg   2340

ggccatagta ttggtcctgt taggtttcgg tcatggaaaa aaaaattatt ttggggtcat   2400

cctggctcta gatgttatgg gcaaatttct gaaacatctg caagaaggta ccagttaatt   2460

atagtgctta atattgggaa taagattaag cattataatt ataatgtatg ggcctgttgg   2520

tgtaagctca gataattaaa taaaaatagc atgactcaaa tgagacatat tctgctgaac   2580

agtttctact tcctctcccg cctgtcctgt catgggagac gtgtatagtt gctgctgttt   2640

cagcaaacca ccataagacg aaaatgcctc aggttgggtt gccagtcctt tacaactcag   2700

cttgaatttc acaacagtga ttgtgagaat ctgcgtggta tacactgaaa tatcggtgtg   2760

ctgtgatgca aagcttacct ttgacgatat tgaatgtgat atagctgtag agaagtactt   2820

ccttgcctta tgtgaggatt tcaaacttat ttaaattatg tagacaaatc aaagtggcat   2880

tgcttaattt ttagcaggca taataagcaa gttaacagta aaatgcaaaa catgataagc   2940

gttgctcaat ttttagcagg tataataagc aggttaacag taaaaatgca aaacatgata   3000

gataagtcac tttgaaaatt caaaccaaag ttccttcacc ttatggaaat aggaaattat   3060

ggacttcaaa attggacact tcctgtttac aaaaagaaat tcagagctaa aatcatggta   3120

aaaaaaaata gaaacacttg agaactatgg tctttatggg tgcaatttga aatccttttc   3180

atcatcttac cagactaaac taagagcaca taccaaacct atcttatggt tgaaagttgg   3240

ggtttatttt ttatatgaga atattatcac tattacataa catactcagg acaaagaact   3300

ttgctcaggg aacataccat gtaatatttt tgttgtttct ttacagacta gtctacagtc   3360

ctgcttactc aaaacaaacc aaataactta tacctttata taagtattat gtactgatga   3420

tagtaactac ctctgagttt gacacagatc aaaatttttg aatatcagat atcagttatc   3480

ctatttttat ttcatgtgaa aactcctcta aagcagattc cctcaactct gtgcatatgt   3540

gaatatcact gatgtgaaca cattgttcat ttacataggt aaaatattac tctgtttaca   3600

gcaaaaggct acctcatagt tgatacatag cacacctgta tgtatgctgt tccagcctta   3660

caggtggctg ataattctct ggtacagaac ctttttatct gtattataaa tagcaattca   3720

caactgcatg tttctgacaa acacttgtga ataatgaagc atctcgtttt agttagcaaa   3780

gtctccaaac atttccttaa aataatcatg tatttagttt aaagaattat gggcactgtt   3840

caacttaagc aaaacagaac acggaagcag tcttagaagc accactttgc ccagaggtgg   3900

aggttggaag gggtagcagg gagaggggtt ggtgtatgca ggtattcatg ctaggcaaag   3960

agtttaaaag acgccaatgt ccttcattta ctgtctgtgc tgccctgaag ccaagcgtat   4020

tgcagcatta tagccccagg cacataacta actagcactg gcttgccaag gaatgaacat   4080

gcaatgccat tactagctat tgagggaaaa gggtctgtgt gaagcatcac tttgcaggga   4140

ttactaatgg tggggcagca ggtctgtgaa ttaagttatc tcttgacctc accctcatgt   4200

caacacaaat gtaattccta aacaagatgc attgccagtc tcttagccct gtaagctgat   4260

cttttgctac atggcagact ataatgaaaa catttttata cttgggtttc tagtcttcac   4320

tagaaggcct tggatgtatt tttgcagttg aaagatttag aaagattttt acctgcttat   4380

aacttggaag tttagagtgc aatgtaagaa aaaagatcaa gaaatgtcat gttattagca   4440

tcagtccacc tccaatattg ccgatacttt ttttattctg gctcagtttt attttgcacc   4500

agtgcggccc caagttactg ctggttgtat ttagtttgtg aataggagcc cataagtgtt   4560

aatagacttt gtaacattca ctataagatg aattatacag gacatgggaa atctcattaa   4620

gtcttaaagt taatttaaat taatttatct gttttctcta agaaatgttt atcataaaat   4680

atatatgtgt atttcccctt tggttataaa atttgggaaa gtatgtacaa gtgcagctgc   4740

actgacttta attttctaga tgtcttaatg agatttattt gttttagaga agaacatctt   4800

gttaaaagca tcaaactctg tcttacatag ctgtcaacag cctctttaag atgtggtggt   4860

tgtatgatct gtgtcttaat tgttcagtta gagtgagaag ttgacctatg attcattttt   4920

aaattttata tttggaacaa agctgcaagt tatggtaaag tactgtactg tgagaagtat   4980

tatgatattt aatgcatctg tggcttaaca cttgtgagag ttaccagctt gaaaatgatg   5040

gtgttgacta cctcttgaat cacatctatc aaccactggc acctaccacc aagctggctt   5100

caattagtat gtgttgcttt ttggtattaa caactaaccg tactagagac caaagtgaac   5160

cctgattttt atatgtcttt aataatggtg ttttatctag tgtttttaaa ttatcctgtg   5220

tagtatttag attacctcat tgtccatttt gactcatgtt gtttacaagt gaaaataaaa   5280

acacttgaac tgtatgtttt taaaagacaa aaaaggggta gatgtttgga atgcgtttca   5340

ctcgcatgca gtcatctgga gggactgaag cactgtttgc ctttctgtac actctgggtt   5400

ttatattctc atttcatgcc taatgtctta ttctgtcaat tatggatatg ttgaggttta   5460

aaaaaattac ttgattaaaa ataaaacata taacgttggc attt                    5504


<210>  1852
<211>  250
<212>  PRT
<213>  Homosapiens

<400>  1852

Met Ala Glu Gly Gly Ala Ser Lys Gly Gly Gly Glu Glu Pro Gly Lys 
1               5                   10                  15      


Leu Pro Glu Pro Ala Glu Glu Glu Ser Gln Val Leu Arg Gly Thr Gly 
            20                  25                  30          


His Cys Lys Trp Phe Asn Val Arg Met Gly Phe Gly Phe Ile Ser Met 
        35                  40                  45              


Ile Asn Arg Glu Gly Ser Pro Leu Asp Ile Pro Val Asp Val Phe Val 
    50                  55                  60                  


His Gln Ser Lys Leu Phe Met Glu Gly Phe Arg Ser Leu Lys Glu Gly 
65                  70                  75                  80  


Glu Pro Val Glu Phe Thr Phe Lys Lys Ser Ser Lys Gly Leu Glu Ser 
                85                  90                  95      


Ile Arg Val Thr Gly Pro Gly Gly Ser Pro Cys Leu Gly Ser Glu Arg 
            100                 105                 110         


Arg Pro Lys Gly Lys Thr Leu Gln Lys Arg Lys Pro Lys Gly Asp Arg 
        115                 120                 125             


Cys Tyr Asn Cys Gly Gly Leu Asp His His Ala Lys Glu Cys Ser Leu 
    130                 135                 140                 


Pro Pro Gln Pro Lys Lys Cys His Tyr Cys Gln Ser Ile Met His Met 
145                 150                 155                 160 


Val Ala Asn Cys Pro His Lys Asn Val Ala Gln Pro Pro Ala Ser Ser 
                165                 170                 175     


Gln Gly Arg Gln Glu Ala Glu Ser Gln Pro Cys Thr Ser Thr Leu Pro 
            180                 185                 190         


Arg Glu Val Gly Gly Gly His Gly Cys Thr Ser Pro Pro Phe Pro Gln 
        195                 200                 205             


Glu Ala Arg Ala Glu Ile Ser Glu Arg Ser Gly Arg Ser Pro Gln Glu 
    210                 215                 220                 


Ala Ser Ser Thr Lys Ser Ser Ile Ala Pro Glu Glu Gln Ser Lys Lys 
225                 230                 235                 240 


Gly Pro Ser Val Gln Lys Arg Lys Lys Thr 
                245                 250 


<210>  1853
<211>  5437
<212>  DNA
<213>  Homosapiens

<400>  1853
caggcagccc cagcgtcccc gggccctcgg ccccaccgag tgccggctcc cgcgctctgc     60

ggcggcaagc cccttggaat tttcaaaatg aattatacag agtccagccc attgagagaa    120

tcaactgcca taggttttac acctgagtta gaaagtatca tacctgtgcc ttccaataag    180

accacttgtg aaaactggag agagatacat catctggttt ttcatgtagc aaatatttgt    240

tttgcagttg ggttggttat tccaactact cttcaccttc atatgatatt tcttagggga    300

atgttaactc taggatgtac cctttatatc gtctgggcca ctctctaccg atgtgccttg    360

gatataatga tctggaactc tgtgttcttg ggtgtcaaca ttttgcatct gtcgtatctt    420

ttatacaaga agagaccggt aaagattgaa aaggaactca gtggcatgta ccggcgattg    480

tttgaaccac tccgtgtgcc tccagatttg ttcagaagac taactggaca gttttgcatg    540

atccaaacct tgaaaaaggg ccaaacttat gctgcagagg ataaaacctc agttgatgac    600

cgtctgagta ttctcttgaa gggaaaaatg aaggtctcct atcgaggaca ttttctgcat    660

aacatttacc cctgtgcctt tatagattct cctgaattta gatcaactca gatgcacaaa    720

ggtgaaaaat tccaggtcac cattattgca gatgataact gcagattttt atgctggtca    780

agagaaagat taacatactt tctggaatca gaacctttct tgtatgaaat ctttaggtat    840

cttattggaa aagacatcac aaataagctc tactcattga atgatcccac cttaaatgat    900

aaaaaagcca aaaagctgga acatcagctc agcctctgca cacagatctc catgttggaa    960

atgaggaaca gtatagccag ctccagtgac agtgacgacg gcttgcacca gtttcttcgg   1020

ggtacctcca gcatgtcctc tcttcatgtg tcatccccac accagcgagc ctctgccaag   1080

atgaaaccga tagaagaagg agcagaagat gatgatgacg tttttgaacc ggcatctcca   1140

aatacattga aagtccatca gctgccttga tcagagagag aattcaggtt accaagacgg   1200

aaggtgtctt gaagagatcc tgaaaaatac cagcactttt tcatggcttt taggttattc   1260

tgctttagtg catccagact ggtagagtcg gagggaggaa gtgaggaagg gtcaaggatg   1320

gaagagttct ttcacttacc ctttttatta gtcagctttt aaagtaattg ttttactgag   1380

ccttctgact atgccttgtt ctcttttgag atatatattt tcacagtctt ttctagatat   1440

attattgttt taacttaaca aatcttagca atctctcaat gccttttcac ttattttttt   1500

ccaagttatg attctttttc ctcacagtct tttttgttcc atagcaatga ggttgtccat   1560

ttgataattt taacaaacaa tgtaagttta aaattgaggc taaggtaaca tgaaaaagca   1620

gggaatctca aactttattc catatataca cacacacaca cacacacaca cacacacata   1680

catacataca tatatatata tatatacata tatatacata cacacataca tataattttt   1740

tttttttttg agatggagtt tcactctgtc gcccaggctg gagtgtagtg gcacattctc   1800

agctcactgc aaactccacc tcctggattc acgccactct cctgcctcag cctcccgagt   1860

agctgggact acaggcacct gccaccgcgc ccagctaatt tttttgtatt tttagtagag   1920

atggggtttc actgtgttag ccaggatggt ctcgatctcc tgacctcgtg atccgcccac   1980

cttggcctcc cagagtgctg ggattacagg cgtgagccac cgcgcccggc ctattccata   2040

tttttttaat gggacatttt agagaaaggt gtgatttgac tggttttatt tttctcccag   2100

gccagaagta ttactccact agatcacctt acttaattgg gcactgtgtg gataacttga   2160

taatgaacaa aactctcaga ttttactcac attacccttg tattatgcca tttataaact   2220

gctctgaaac ctgaagctgg aaagataaca gatgggtttc tgagcacggg gttaacctcc   2280

agctaaactc aacttccttg ggatttggag tcaccatgtt gtgcacactc tggtgtggga   2340

aacactttat gtagggtggg aggacagggg agttaaatgg ctgggcaggt gccacaggat   2400

gaggccactg aaagatctgc ttcattcttt gatctgtatt ctgaagttcc agattgttca   2460

tctagaggca gagacatctc ttttaaaaaa gtgccagatg ccccagtgcc agagctgcga   2520

acgtgaacac agtggaaggc agagggttta ctacaggcca ggccatggac accccaccca   2580

ggtactgcag tgagggcctt gattccagag ctctttttcc tactgaaatc atggtttagt   2640

aaacagtggc atttggctgg tgggaaatgc gtaactggtc agtgtgtctg gccagcgtgg   2700

ctgtggcact tggccaggac gctccgttga atgaagctca ttgattggcc atgctggtca   2760

tgtctatttt gcttcatcca ctagaaccaa ctttgagtca gtctcctgtt acgttaaatg   2820

gctaagaaaa gttccaaatg aagttgttct caggtgaact gagccaaaag aagcaactct   2880

taccatgagg tgatttctgt tagaggagac atataaataa gctcatctag ggtcacctca   2940

ttttcctaaa tatgttttta aagcaattat tgtagtaatt tcatttgagt taaatttaca   3000

tgctcggtca ctcattgaga aaatttacac agactctgaa tccagttcct gtcatcttca   3060

gatgttggtt tattgacatc acagtaaaaa ggctactgtc gactggacac agtggctcac   3120

acatgtaatc acagcacttt ggggggccaa ggtgggtgga ttgcttaagc ccaggagttc   3180

aagaccagcc tgggcaacat ggctaaaccc catctctaca aaaaaaatta gctgggtgtg   3240

gtggtacata cctgtagtcc cagctactca gaaggctgag gtgggaggtt cacttgaacc   3300

tgggaggttg aggttgcagt gagcacagat cacaccactg cactccagcc tgggcaacag   3360

agtgagaccc tatttcaaaa aaaggctgct ttcactgtac tgctgcagca gtctcttcag   3420

gtagctaaat taggagcttg ttttggagaa atgaagcaaa ggtgaatgac agcctaggct   3480

tgaaattata aagctctctc aggttgaact ctctcgtgcg ctctcgctct cactttcgcc   3540

ctgtacctga gagcacaggt gtaactgtga tgtcatagtg ccgagactac tttcctttaa   3600

ccattggggt taagttgggc agcccattta gtttacacgc gcataagact aatttacaaa   3660

atcactctat acagtcatta gatgtaacat ccttccctga gtagaaagta atgcatgtgt   3720

ttggagatta ttttctgtaa tgctgggaac aaacctgttt taaaagcaca ctgctaaaag   3780

taggtgatat aagaccattt gctgttttta ttaaagtatg tgtgtgtatc agtgtctcaa   3840

tgtgaagatt gtaacctcaa gattaggaat cttaaaagag ccacttagcc tgaatgggaa   3900

acgtgagact atttttaaac acacacctct aaggaagaag cctcccatat agacttgatc   3960

tcaaagaagc agataagaag acagaaaagt gttttaagtg taagatctcc tatggagtac   4020

tttaaattca tttatacaaa tgaataagtg tatctttgta taatgcataa atacatagat   4080

aaaaacatgt ttgctgccaa agttcccaat aagatgcttc ctgtgttttt tggcctttac   4140

ttagctgaat gatcaaagtt cagaaaatgg tctgcaaaag ttactccata tacaacccca   4200

aatctactac tttaaatgta acatcaactc agttgtatga atctggagtg taatatttat   4260

attagaatgt atatgtcatt taaaatattt tgaaagccct cataaatatt tatatttact   4320

aaactaatag catagacact atataaatcc gcagtgatgc ttatatatct taaattagta   4380

ataatgggtg ctatataatt attttcagtt actatccctg acactctgga atcttctcca   4440

tttctcccta tcactcaatt tcattttaat cattggacac ctttgcgttt tgctgctaac   4500

agtgtgtgta tgtcaccctc tttatatctg gttttcccac ttgtctgaag ctctcctgat   4560

cttagaacct ggagctgcag attcctccat gtcagctccc atcacggccc caaagacaga   4620

gtcacttggt tgctgagtca cttggttgct ggaaaaatct ttggggaaag ctggtataag   4680

ctacacactg acctgtcccc agtgtttcca ggtaatgact tggcactcca gagaaagttt   4740

catgctgttg cgtgtggtgg ctccaagcca agcacctggc atgcaggtca gcccttccca   4800

gcgggcgtgg cgtcgtcctc ttcacagatg ccacgttgca gccccaaggc ctcaccattt   4860

tgcgtttttt agaaacccat tttcttggtc atttataaag ctgctttata gatatctttg   4920

atcctggcat gccttggttt cctctccctt ccctctttcc aatcctggtt tcctaacctc   4980

ctcttgtagt aattctcaac tcaactcaaa gtcccaagaa tttggaatgg taggatgctg   5040

tgcggggagc tcgaggctga ggcataatca ctgcttcggt tctgctcatc aggggacacg   5100

ctcccttact catggcagcc atgtttgatt gtcacagagc cccccgaata ctctgtctat   5160

agtgacacac tgtaggtgtc ataaatttta agaaacctgc ttttaagtac tatttatagg   5220

tttttctgtt atacttgcaa cctagtttta aaatacatga ggattttatg aaagctttat   5280

acagacattt ataggaaact cattctttga ttttaggtgc catttaaatt gataacactt   5340

actttataaa aagatgcttt ttgtctggat agagccttat agtttaaaat atcttcatat   5400

attgccattt gatcaaataa atttcttact tagaaaa                            5437


<210>  1854
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  1854

Met Asn Tyr Thr Glu Ser Ser Pro Leu Arg Glu Ser Thr Ala Ile Gly 
1               5                   10                  15      


Phe Thr Pro Glu Leu Glu Ser Ile Ile Pro Val Pro Ser Asn Lys Thr 
            20                  25                  30          


Thr Cys Glu Asn Trp Arg Glu Ile His His Leu Val Phe His Val Ala 
        35                  40                  45              


Asn Ile Cys Phe Ala Val Gly Leu Val Ile Pro Thr Thr Leu His Leu 
    50                  55                  60                  


His Met Ile Phe Leu Arg Gly Met Leu Thr Leu Gly Cys Thr Leu Tyr 
65                  70                  75                  80  


Ile Val Trp Ala Thr Leu Tyr Arg Cys Ala Leu Asp Ile Met Ile Trp 
                85                  90                  95      


Asn Ser Val Phe Leu Gly Val Asn Ile Leu His Leu Ser Tyr Leu Leu 
            100                 105                 110         


Tyr Lys Lys Arg Pro Val Lys Ile Glu Lys Glu Leu Ser Gly Met Tyr 
        115                 120                 125             


Arg Arg Leu Phe Glu Pro Leu Arg Val Pro Pro Asp Leu Phe Arg Arg 
    130                 135                 140                 


Leu Thr Gly Gln Phe Cys Met Ile Gln Thr Leu Lys Lys Gly Gln Thr 
145                 150                 155                 160 


Tyr Ala Ala Glu Asp Lys Thr Ser Val Asp Asp Arg Leu Ser Ile Leu 
                165                 170                 175     


Leu Lys Gly Lys Met Lys Val Ser Tyr Arg Gly His Phe Leu His Asn 
            180                 185                 190         


Ile Tyr Pro Cys Ala Phe Ile Asp Ser Pro Glu Phe Arg Ser Thr Gln 
        195                 200                 205             


Met His Lys Gly Glu Lys Phe Gln Val Thr Ile Ile Ala Asp Asp Asn 
    210                 215                 220                 


Cys Arg Phe Leu Cys Trp Ser Arg Glu Arg Leu Thr Tyr Phe Leu Glu 
225                 230                 235                 240 


Ser Glu Pro Phe Leu Tyr Glu Ile Phe Arg Tyr Leu Ile Gly Lys Asp 
                245                 250                 255     


Ile Thr Asn Lys Leu Tyr Ser Leu Asn Asp Pro Thr Leu Asn Asp Lys 
            260                 265                 270         


Lys Ala Lys Lys Leu Glu His Gln Leu Ser Leu Cys Thr Gln Ile Ser 
        275                 280                 285             


Met Leu Glu Met Arg Asn Ser Ile Ala Ser Ser Ser Asp Ser Asp Asp 
    290                 295                 300                 


Gly Leu His Gln Phe Leu Arg Gly Thr Ser Ser Met Ser Ser Leu His 
305                 310                 315                 320 


Val Ser Ser Pro His Gln Arg Ala Ser Ala Lys Met Lys Pro Ile Glu 
                325                 330                 335     


Glu Gly Ala Glu Asp Asp Asp Asp Val Phe Glu Pro Ala Ser Pro Asn 
            340                 345                 350         


Thr Leu Lys Val His Gln Leu Pro 
        355                 360 


<210>  1855
<211>  5507
<212>  DNA
<213>  Homosapiens

<400>  1855
agagcgccga tggctgggga cccgaggtcc gcgccaccca cccgcaacct ccttccccga     60

gcctttggga acgggttgtt ggccagacaa gtcccagaaa ctgcctgctt tgaagcatga    120

ataagtgcga aaagactctt agcaatgaat tttcaaaatg aattatacag agtccagccc    180

attgagagaa tcaactgcca taggttttac acctgagtta gaaagtatca tacctgtgcc    240

ttccaataag accacttgtg aaaactggag agagatacat catctggttt ttcatgtagc    300

aaatatttgt tttgcagttg ggttggttat tccaactact cttcaccttc atatgatatt    360

tcttagggga atgttaactc taggatgtac cctttatatc gtctgggcca ctctctaccg    420

atgtgccttg gatataatga tctggaactc tgtgttcttg ggtgtcaaca ttttgcatct    480

gtcgtatctt ttatacaaga agagaccggt aaagattgaa aaggaactca gtggcatgta    540

ccggcgattg tttgaaccac tccgtgtgcc tccagatttg ttcagaagac taactggaca    600

gttttgcatg atccaaacct tgaaaaaggg ccaaacttat gctgcagagg ataaaacctc    660

agttgatgac cgtctgagta ttctcttgaa gggaaaaatg aaggtctcct atcgaggaca    720

ttttctgcat aacatttacc cctgtgcctt tatagattct cctgaattta gatcaactca    780

gatgcacaaa ggtgaaaaat tccaggtcac cattattgca gatgataact gcagattttt    840

atgctggtca agagaaagat taacatactt tctggaatca gaacctttct tgtatgaaat    900

ctttaggtat cttattggaa aagacatcac aaataagctc tactcattga atgatcccac    960

cttaaatgat aaaaaagcca aaaagctgga acatcagctc agcctctgca cacagatctc   1020

catgttggaa atgaggaaca gtatagccag ctccagtgac agtgacgacg gcttgcacca   1080

gtttcttcgg ggtacctcca gcatgtcctc tcttcatgtg tcatccccac accagcgagc   1140

ctctgccaag atgaaaccga tagaagaagg agcagaagat gatgatgacg tttttgaacc   1200

ggcatctcca aatacattga aagtccatca gctgccttga tcagagagag aattcaggtt   1260

accaagacgg aaggtgtctt gaagagatcc tgaaaaatac cagcactttt tcatggcttt   1320

taggttattc tgctttagtg catccagact ggtagagtcg gagggaggaa gtgaggaagg   1380

gtcaaggatg gaagagttct ttcacttacc ctttttatta gtcagctttt aaagtaattg   1440

ttttactgag ccttctgact atgccttgtt ctcttttgag atatatattt tcacagtctt   1500

ttctagatat attattgttt taacttaaca aatcttagca atctctcaat gccttttcac   1560

ttattttttt ccaagttatg attctttttc ctcacagtct tttttgttcc atagcaatga   1620

ggttgtccat ttgataattt taacaaacaa tgtaagttta aaattgaggc taaggtaaca   1680

tgaaaaagca gggaatctca aactttattc catatataca cacacacaca cacacacaca   1740

cacacacata catacataca tatatatata tatatacata tatatacata cacacataca   1800

tataattttt tttttttttg agatggagtt tcactctgtc gcccaggctg gagtgtagtg   1860

gcacattctc agctcactgc aaactccacc tcctggattc acgccactct cctgcctcag   1920

cctcccgagt agctgggact acaggcacct gccaccgcgc ccagctaatt tttttgtatt   1980

tttagtagag atggggtttc actgtgttag ccaggatggt ctcgatctcc tgacctcgtg   2040

atccgcccac cttggcctcc cagagtgctg ggattacagg cgtgagccac cgcgcccggc   2100

ctattccata tttttttaat gggacatttt agagaaaggt gtgatttgac tggttttatt   2160

tttctcccag gccagaagta ttactccact agatcacctt acttaattgg gcactgtgtg   2220

gataacttga taatgaacaa aactctcaga ttttactcac attacccttg tattatgcca   2280

tttataaact gctctgaaac ctgaagctgg aaagataaca gatgggtttc tgagcacggg   2340

gttaacctcc agctaaactc aacttccttg ggatttggag tcaccatgtt gtgcacactc   2400

tggtgtggga aacactttat gtagggtggg aggacagggg agttaaatgg ctgggcaggt   2460

gccacaggat gaggccactg aaagatctgc ttcattcttt gatctgtatt ctgaagttcc   2520

agattgttca tctagaggca gagacatctc ttttaaaaaa gtgccagatg ccccagtgcc   2580

agagctgcga acgtgaacac agtggaaggc agagggttta ctacaggcca ggccatggac   2640

accccaccca ggtactgcag tgagggcctt gattccagag ctctttttcc tactgaaatc   2700

atggtttagt aaacagtggc atttggctgg tgggaaatgc gtaactggtc agtgtgtctg   2760

gccagcgtgg ctgtggcact tggccaggac gctccgttga atgaagctca ttgattggcc   2820

atgctggtca tgtctatttt gcttcatcca ctagaaccaa ctttgagtca gtctcctgtt   2880

acgttaaatg gctaagaaaa gttccaaatg aagttgttct caggtgaact gagccaaaag   2940

aagcaactct taccatgagg tgatttctgt tagaggagac atataaataa gctcatctag   3000

ggtcacctca ttttcctaaa tatgttttta aagcaattat tgtagtaatt tcatttgagt   3060

taaatttaca tgctcggtca ctcattgaga aaatttacac agactctgaa tccagttcct   3120

gtcatcttca gatgttggtt tattgacatc acagtaaaaa ggctactgtc gactggacac   3180

agtggctcac acatgtaatc acagcacttt ggggggccaa ggtgggtgga ttgcttaagc   3240

ccaggagttc aagaccagcc tgggcaacat ggctaaaccc catctctaca aaaaaaatta   3300

gctgggtgtg gtggtacata cctgtagtcc cagctactca gaaggctgag gtgggaggtt   3360

cacttgaacc tgggaggttg aggttgcagt gagcacagat cacaccactg cactccagcc   3420

tgggcaacag agtgagaccc tatttcaaaa aaaggctgct ttcactgtac tgctgcagca   3480

gtctcttcag gtagctaaat taggagcttg ttttggagaa atgaagcaaa ggtgaatgac   3540

agcctaggct tgaaattata aagctctctc aggttgaact ctctcgtgcg ctctcgctct   3600

cactttcgcc ctgtacctga gagcacaggt gtaactgtga tgtcatagtg ccgagactac   3660

tttcctttaa ccattggggt taagttgggc agcccattta gtttacacgc gcataagact   3720

aatttacaaa atcactctat acagtcatta gatgtaacat ccttccctga gtagaaagta   3780

atgcatgtgt ttggagatta ttttctgtaa tgctgggaac aaacctgttt taaaagcaca   3840

ctgctaaaag taggtgatat aagaccattt gctgttttta ttaaagtatg tgtgtgtatc   3900

agtgtctcaa tgtgaagatt gtaacctcaa gattaggaat cttaaaagag ccacttagcc   3960

tgaatgggaa acgtgagact atttttaaac acacacctct aaggaagaag cctcccatat   4020

agacttgatc tcaaagaagc agataagaag acagaaaagt gttttaagtg taagatctcc   4080

tatggagtac tttaaattca tttatacaaa tgaataagtg tatctttgta taatgcataa   4140

atacatagat aaaaacatgt ttgctgccaa agttcccaat aagatgcttc ctgtgttttt   4200

tggcctttac ttagctgaat gatcaaagtt cagaaaatgg tctgcaaaag ttactccata   4260

tacaacccca aatctactac tttaaatgta acatcaactc agttgtatga atctggagtg   4320

taatatttat attagaatgt atatgtcatt taaaatattt tgaaagccct cataaatatt   4380

tatatttact aaactaatag catagacact atataaatcc gcagtgatgc ttatatatct   4440

taaattagta ataatgggtg ctatataatt attttcagtt actatccctg acactctgga   4500

atcttctcca tttctcccta tcactcaatt tcattttaat cattggacac ctttgcgttt   4560

tgctgctaac agtgtgtgta tgtcaccctc tttatatctg gttttcccac ttgtctgaag   4620

ctctcctgat cttagaacct ggagctgcag attcctccat gtcagctccc atcacggccc   4680

caaagacaga gtcacttggt tgctgagtca cttggttgct ggaaaaatct ttggggaaag   4740

ctggtataag ctacacactg acctgtcccc agtgtttcca ggtaatgact tggcactcca   4800

gagaaagttt catgctgttg cgtgtggtgg ctccaagcca agcacctggc atgcaggtca   4860

gcccttccca gcgggcgtgg cgtcgtcctc ttcacagatg ccacgttgca gccccaaggc   4920

ctcaccattt tgcgtttttt agaaacccat tttcttggtc atttataaag ctgctttata   4980

gatatctttg atcctggcat gccttggttt cctctccctt ccctctttcc aatcctggtt   5040

tcctaacctc ctcttgtagt aattctcaac tcaactcaaa gtcccaagaa tttggaatgg   5100

taggatgctg tgcggggagc tcgaggctga ggcataatca ctgcttcggt tctgctcatc   5160

aggggacacg ctcccttact catggcagcc atgtttgatt gtcacagagc cccccgaata   5220

ctctgtctat agtgacacac tgtaggtgtc ataaatttta agaaacctgc ttttaagtac   5280

tatttatagg tttttctgtt atacttgcaa cctagtttta aaatacatga ggattttatg   5340

aaagctttat acagacattt ataggaaact cattctttga ttttaggtgc catttaaatt   5400

gataacactt actttataaa aagatgcttt ttgtctggat agagccttat agtttaaaat   5460

atcttcatat attgccattt gatcaaataa atttcttact tagaaaa                 5507


<210>  1856
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  1856

Met Asn Tyr Thr Glu Ser Ser Pro Leu Arg Glu Ser Thr Ala Ile Gly 
1               5                   10                  15      


Phe Thr Pro Glu Leu Glu Ser Ile Ile Pro Val Pro Ser Asn Lys Thr 
            20                  25                  30          


Thr Cys Glu Asn Trp Arg Glu Ile His His Leu Val Phe His Val Ala 
        35                  40                  45              


Asn Ile Cys Phe Ala Val Gly Leu Val Ile Pro Thr Thr Leu His Leu 
    50                  55                  60                  


His Met Ile Phe Leu Arg Gly Met Leu Thr Leu Gly Cys Thr Leu Tyr 
65                  70                  75                  80  


Ile Val Trp Ala Thr Leu Tyr Arg Cys Ala Leu Asp Ile Met Ile Trp 
                85                  90                  95      


Asn Ser Val Phe Leu Gly Val Asn Ile Leu His Leu Ser Tyr Leu Leu 
            100                 105                 110         


Tyr Lys Lys Arg Pro Val Lys Ile Glu Lys Glu Leu Ser Gly Met Tyr 
        115                 120                 125             


Arg Arg Leu Phe Glu Pro Leu Arg Val Pro Pro Asp Leu Phe Arg Arg 
    130                 135                 140                 


Leu Thr Gly Gln Phe Cys Met Ile Gln Thr Leu Lys Lys Gly Gln Thr 
145                 150                 155                 160 


Tyr Ala Ala Glu Asp Lys Thr Ser Val Asp Asp Arg Leu Ser Ile Leu 
                165                 170                 175     


Leu Lys Gly Lys Met Lys Val Ser Tyr Arg Gly His Phe Leu His Asn 
            180                 185                 190         


Ile Tyr Pro Cys Ala Phe Ile Asp Ser Pro Glu Phe Arg Ser Thr Gln 
        195                 200                 205             


Met His Lys Gly Glu Lys Phe Gln Val Thr Ile Ile Ala Asp Asp Asn 
    210                 215                 220                 


Cys Arg Phe Leu Cys Trp Ser Arg Glu Arg Leu Thr Tyr Phe Leu Glu 
225                 230                 235                 240 


Ser Glu Pro Phe Leu Tyr Glu Ile Phe Arg Tyr Leu Ile Gly Lys Asp 
                245                 250                 255     


Ile Thr Asn Lys Leu Tyr Ser Leu Asn Asp Pro Thr Leu Asn Asp Lys 
            260                 265                 270         


Lys Ala Lys Lys Leu Glu His Gln Leu Ser Leu Cys Thr Gln Ile Ser 
        275                 280                 285             


Met Leu Glu Met Arg Asn Ser Ile Ala Ser Ser Ser Asp Ser Asp Asp 
    290                 295                 300                 


Gly Leu His Gln Phe Leu Arg Gly Thr Ser Ser Met Ser Ser Leu His 
305                 310                 315                 320 


Val Ser Ser Pro His Gln Arg Ala Ser Ala Lys Met Lys Pro Ile Glu 
                325                 330                 335     


Glu Gly Ala Glu Asp Asp Asp Asp Val Phe Glu Pro Ala Ser Pro Asn 
            340                 345                 350         


Thr Leu Lys Val His Gln Leu Pro 
        355                 360 


<210>  1857
<211>  1854
<212>  DNA
<213>  Homosapiens

<400>  1857
gcccgctgcg gtcacgctgc gcccggcgcc gcagggtggg cggcgaggca ctcacgaggg     60

ggacgctgag ggcttccgcg cgggccaccc gggtcaagcg cgctccgccg ggaaacttct    120

gcgggcgccg ggctgaagct ccgggcaggg ctgggaagga aaggaaatac caaaatattt    180

gcagactgga tccaaatcag gagcccagat gaacttaaag aagcgagcat gggattctta    240

gtttttcaag atccgtacac acgaagcctt taatcagcat caactccagt gtccgttttc    300

tctggttttg tgaagactgc acaaaactct catgatggag aaccaaagga cttagttacc    360

tgtttcagtg tcatctaaag tcaactgaaa agtgaagcag gcagtaatac agccatggaa    420

agaaattcaa gtttatggaa gaacctaata gatgaacacc cagtctgcac aacctggaag    480

caagaggccg aaggagccat ttatcatctt gccagtattt tatttgtagt aggtttcatg    540

ggtggcagtg gattcttcgg gctcctttat gtcttcagtt tgctggggtt gggttttctc    600

tgttctgctg tctgggcttg ggtagatgtc tgtgcagctg acatattttc ctggaatttt    660

gtactgtttg tcatctgctt catgcaattt gttcatattg catatcaagt tcgcagcata    720

acctttgccc gagaattcca agtgttgtac agctcccttt tccagcccct ggggatctct    780

ttgcctgtct tcagaacgat tgctttgagc tctgaagtgg ttactttgga aaaggaacac    840

tgttatgcca tgcaggggaa aacttccatt gataaactct ccttgcttgt ttcaggaagg    900

atcagagtga cagttgatgg cgaatttctg cattacattt tcccccttca gttcctggat    960

tctcctgagt gggattcact gagacccaca gaggaaggca tttttcaggt aaccctcact   1020

gcagaaactg attgtcgata tgtgtcttgg aggagaaaga aattatatct gctctttgct   1080

cagcatcgct acatctcccg ccttttttca gtgctaattg gcagtgacat tgcagataaa   1140

ctctatgcct tgaatgacag ggtatatata ggaaaaagat atcactatga tattcggcta   1200

cccaacttct atcaaatgtc aactccagaa atacgcagat cacccctgac acaacatttt   1260

cagaattcca gacgatactg tgataaatga catcaaagtc tgaaatttat aagtataaaa   1320

aaagactctc tcttcatcat tccccagtga aatagcaaaa tacaaaaaaa gagctcccta   1380

atgtttttat aaatcaaatt cagaagcgag atgccattgc caactgtttt attcctttca   1440

acaactgcat tgtgaataaa ctttacaaat ttttcttgta tttctcattg ttataattgg   1500

ggagggggtg gataactatg ggcagtttgc ccttttctgc atcaaaactg ggagaatgaa   1560

attccacttt ctcaattctt ttctcacatt tactcaaatg cattgtcttg ccctatggac   1620

tcaggagttg cttctcaaga aacagccagc aagtattctc agcctgaggg tgggttgcta   1680

ctgtccacat aggcatttcc ggaattcact tttttgctac aacctccagt gaaagcaatt   1740

attttaaatg tgcagttact tgatgtgact aaaaagtaga ataaatgcaa gagataataa   1800

tatgtgaatc ttgaagccta ttttattgct acaaataaaa taacatttaa aaag         1854


<210>  1858
<211>  291
<212>  PRT
<213>  Homosapiens

<400>  1858

Met Glu Arg Asn Ser Ser Leu Trp Lys Asn Leu Ile Asp Glu His Pro 
1               5                   10                  15      


Val Cys Thr Thr Trp Lys Gln Glu Ala Glu Gly Ala Ile Tyr His Leu 
            20                  25                  30          


Ala Ser Ile Leu Phe Val Val Gly Phe Met Gly Gly Ser Gly Phe Phe 
        35                  40                  45              


Gly Leu Leu Tyr Val Phe Ser Leu Leu Gly Leu Gly Phe Leu Cys Ser 
    50                  55                  60                  


Ala Val Trp Ala Trp Val Asp Val Cys Ala Ala Asp Ile Phe Ser Trp 
65                  70                  75                  80  


Asn Phe Val Leu Phe Val Ile Cys Phe Met Gln Phe Val His Ile Ala 
                85                  90                  95      


Tyr Gln Val Arg Ser Ile Thr Phe Ala Arg Glu Phe Gln Val Leu Tyr 
            100                 105                 110         


Ser Ser Leu Phe Gln Pro Leu Gly Ile Ser Leu Pro Val Phe Arg Thr 
        115                 120                 125             


Ile Ala Leu Ser Ser Glu Val Val Thr Leu Glu Lys Glu His Cys Tyr 
    130                 135                 140                 


Ala Met Gln Gly Lys Thr Ser Ile Asp Lys Leu Ser Leu Leu Val Ser 
145                 150                 155                 160 


Gly Arg Ile Arg Val Thr Val Asp Gly Glu Phe Leu His Tyr Ile Phe 
                165                 170                 175     


Pro Leu Gln Phe Leu Asp Ser Pro Glu Trp Asp Ser Leu Arg Pro Thr 
            180                 185                 190         


Glu Glu Gly Ile Phe Gln Val Thr Leu Thr Ala Glu Thr Asp Cys Arg 
        195                 200                 205             


Tyr Val Ser Trp Arg Arg Lys Lys Leu Tyr Leu Leu Phe Ala Gln His 
    210                 215                 220                 


Arg Tyr Ile Ser Arg Leu Phe Ser Val Leu Ile Gly Ser Asp Ile Ala 
225                 230                 235                 240 


Asp Lys Leu Tyr Ala Leu Asn Asp Arg Val Tyr Ile Gly Lys Arg Tyr 
                245                 250                 255     


His Tyr Asp Ile Arg Leu Pro Asn Phe Tyr Gln Met Ser Thr Pro Glu 
            260                 265                 270         


Ile Arg Arg Ser Pro Leu Thr Gln His Phe Gln Asn Ser Arg Arg Tyr 
        275                 280                 285             


Cys Asp Lys 
    290     


<210>  1859
<211>  2010
<212>  DNA
<213>  Homosapiens

<400>  1859
ctccccacct tctctcccga aggcgaaaat ggcagggcca ggcgagaacc tgggacagcg     60

gtggccctag ccctgcgatc ctcacccctc ctgctaggag aggctgcggg ctgcccgcgg    120

acgatgtggc cgcggctgct cccgagcgca tcttcggccc gggtccccgc cgccacccct    180

cttctctgct ccttccatcc cgcccagagg agttgatgcc gctgtcgccg ccgccgccgc    240

tgctgaagcc gcggctgatg gatgccaggg agtgccgcat tgcttagcga ccccgcctct    300

gggtttgctg atgatctctc tccgccctgg agctcagcgc tgaagagcta ccttattatt    360

aatcagaatt tccatcgcca cccctggcag gcgtatcctt cagcagggac cgcaggaaca    420

ttcacagtgc aggggctgag atgtgcgtgg gggttgtttt tgttacatct tggaagagaa    480

gagaagagga cagtaccaag atcagaaaca cccgtgctag gtggaattag gggtgatttg    540

ttaggaaaga gaaaggacaa gaagaggagt gcggagccct tcaggggttc acatctcttt    600

aaaggaaagg aaagagggag ccaaagtagg gtgttgtatt ttagggggca gaggaagaag    660

tttacacccc ccggcccccc cagctttgct gggggaaagc aggagcaaca gggcacttga    720

ttggacacca agattattaa tttcctgtag gggagaggaa gcaggcagca ggaggtctgg    780

gggctggagt ctggtggtgg caaggaccag gtttgctttg ggacagtcaa caaggtcttc    840

tgagggaaag ctcagagata ggcagaacaa tgactcattt gcaagccggt ctctcccctg    900

agaccctgga gaaagctcgc ctggagctca atgaaaaccc agacacgctg caccaggaca    960

tccaggaggt gagggatatg gtcatcacca ggccggacat tggctttctg cgcacggatg   1020

atgccttcat cttacgcttc ttgcgggcta ggaagtttca tcactttgag gccttccgcc   1080

tcctggcgca gtactttgag taccggcagc agaacctgga catgttcaaa agctttaagg   1140

ccaccgaccc tggcatcaag caggcactga aggatggctt ccctgggggc ctggccaatc   1200

tggaccacta tggcaggaag attctagtcc tttttgctgc caattgggat cagagcaggt   1260

acacactggt ggatattttg cgtgccatct tactttcttt agaagccatg attgaagatc   1320

ctgagcttca agtgaatggg tttgttttga tcatagactg gagtaacttc actttcaagc   1380

aagcctctaa actcacacca agtatgctgc gattagctat tgaaggcctg caggatagtt   1440

tcccagcgcg atttggagga attcattttg tcaatcaacc atggtatatc catgccctgt   1500

acaccgtgat ccggcctttc ctgaaggaga aaactcggaa aaggatattt ttgcatggta   1560

acaacctgaa cagtctacac caactaattc atcctgagat cctgccctct gagtttggag   1620

gaatgctgcc tccttatgac atggggacat gggcaagaac actgctagac catgaatatg   1680

acgatgacag cgagtacaat gtagactcct acagcatgcc tgtgaaggaa gtagagaagg   1740

aactctcccc aaagtccatg aagagatctc aatcagtagt ggatcctaca gtactaaaac   1800

gcatggataa aaatgaggaa gaaaacatgc aaccattgct ttctctggac taataacttc   1860

tctacatccc cttcatggat tagaaatgga aagtattggt tttcagcaac agggacaaca   1920

ctgtagagga attaccagct ggaaaccgac ttattcatgt taatgtagca taatatataa   1980

caaggcatca ggctttcctt ggcctgaacc                                    2010


<210>  1860
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  1860

Met Thr His Leu Gln Ala Gly Leu Ser Pro Glu Thr Leu Glu Lys Ala 
1               5                   10                  15      


Arg Leu Glu Leu Asn Glu Asn Pro Asp Thr Leu His Gln Asp Ile Gln 
            20                  25                  30          


Glu Val Arg Asp Met Val Ile Thr Arg Pro Asp Ile Gly Phe Leu Arg 
        35                  40                  45              


Thr Asp Asp Ala Phe Ile Leu Arg Phe Leu Arg Ala Arg Lys Phe His 
    50                  55                  60                  


His Phe Glu Ala Phe Arg Leu Leu Ala Gln Tyr Phe Glu Tyr Arg Gln 
65                  70                  75                  80  


Gln Asn Leu Asp Met Phe Lys Ser Phe Lys Ala Thr Asp Pro Gly Ile 
                85                  90                  95      


Lys Gln Ala Leu Lys Asp Gly Phe Pro Gly Gly Leu Ala Asn Leu Asp 
            100                 105                 110         


His Tyr Gly Arg Lys Ile Leu Val Leu Phe Ala Ala Asn Trp Asp Gln 
        115                 120                 125             


Ser Arg Tyr Thr Leu Val Asp Ile Leu Arg Ala Ile Leu Leu Ser Leu 
    130                 135                 140                 


Glu Ala Met Ile Glu Asp Pro Glu Leu Gln Val Asn Gly Phe Val Leu 
145                 150                 155                 160 


Ile Ile Asp Trp Ser Asn Phe Thr Phe Lys Gln Ala Ser Lys Leu Thr 
                165                 170                 175     


Pro Ser Met Leu Arg Leu Ala Ile Glu Gly Leu Gln Asp Ser Phe Pro 
            180                 185                 190         


Ala Arg Phe Gly Gly Ile His Phe Val Asn Gln Pro Trp Tyr Ile His 
        195                 200                 205             


Ala Leu Tyr Thr Val Ile Arg Pro Phe Leu Lys Glu Lys Thr Arg Lys 
    210                 215                 220                 


Arg Ile Phe Leu His Gly Asn Asn Leu Asn Ser Leu His Gln Leu Ile 
225                 230                 235                 240 


His Pro Glu Ile Leu Pro Ser Glu Phe Gly Gly Met Leu Pro Pro Tyr 
                245                 250                 255     


Asp Met Gly Thr Trp Ala Arg Thr Leu Leu Asp His Glu Tyr Asp Asp 
            260                 265                 270         


Asp Ser Glu Tyr Asn Val Asp Ser Tyr Ser Met Pro Val Lys Glu Val 
        275                 280                 285             


Glu Lys Glu Leu Ser Pro Lys Ser Met Lys Arg Ser Gln Ser Val Val 
    290                 295                 300                 


Asp Pro Thr Val Leu Lys Arg Met Asp Lys Asn Glu Glu Glu Asn Met 
305                 310                 315                 320 


Gln Pro Leu Leu Ser Leu Asp 
                325         


<210>  1861
<211>  2165
<212>  DNA
<213>  Homosapiens

<400>  1861
gcggccgccc cggcggctcc tggaaccccg gttcgcggcg atgccagcca ccccagcgaa     60

gccgccgcag ttcagtgctt ggataatttg aaagtacaat agttggtttc cctgtccacc    120

cgccccactt cgcttgccat cacagcacgc ctatcggatg tgagaggaga agtcccgctg    180

ctcgggcact gtctatatac gcctaacacc tacatatatt ttaaaaacat taaatataat    240

taacaatcaa aagaaagagg agaaaggaag ggaagcatta ctgggttact atgcacttgc    300

gactgatttc ttggcttttt atcattttga actttatgga atacatcggc agccaaaacg    360

cctcccgggg aaggcgccag cgaagaatgc atcctaacgt tagtcaaggc tgccaaggag    420

gctgtgcaac atgctcagat tacaatggat gtttgtcatg taagcccaga ctattttttg    480

ctctggaaag aattggcatg aagcagattg gagtatgtct ctcttcatgt ccaagtggat    540

attatggaac tcgatatcca gatataaata agtgtacaaa atgcaaagct gactgtgata    600

cctgtttcaa caaaaatttc tgcacaaaat gtaaaagtgg attttactta caccttggaa    660

agtgccttga caattgccca gaagggttgg aagccaacaa ccatactatg gagtgtgtca    720

gtattgtgca ctgtgaggtc agtgaatgga atccttggag tccatgcacg aagaagggaa    780

aaacatgtgg cttcaaaaga gggactgaaa cacgggtccg agaaataata cagcatcctt    840

cagcaaaggg taacctgtgt cccccaacaa atgagacaag aaagtgtaca gtgcaaagga    900

agaagtgtca gaagggagaa cgaggaaaaa aaggaaggga gaggaaaaga aaaaaaccta    960

ataaaggaga aagtaaagaa gcaatacctg acagcaaaag tctggaatcc agcaaagaaa   1020

tcccagagca acgagaaaac aaacagcagc agaagaagcg aaaagtccaa gataaacaga   1080

aatcggtatc agtcagcact gtacactaga gggttccatg agattattgt agactcatga   1140

tgctgctatc tcaaccagat gcccaggaca ggtgctctag ccattaggac cacaaatgga   1200

catgtcagtt attgctctgt ctaaacaaca ttcccagtag ttgctatatt cttcatacaa   1260

gcatagttaa caacaaagag ccaaaagatc aaagaaggga tactttcaga tggttgtctt   1320

gtgtgcttct ctgcattttt aaaagacaag acattcttgt acatattatc aataggctat   1380

aagatgtaac aacgaaatga tgacatctgg agaagaaaca tcttttcctt ataaaaatgt   1440

gttttcaagc tgttgtttta agaagcaaaa gatagttctg caaattcaaa gatacagtat   1500

cccttcaaaa caaataggag ttcagggaag agaaacatcc ttcaaaggac agtgttgttt   1560

tgaccgggag atctagagag tgctcagaat tagggcctgg catttggaat cacaggattt   1620

atcatcacag aaacaactgt tttaagatta gttccatcac tctcatcctg tatttttata   1680

agaaacacaa gagtgcatac cagaattgaa tataccatat gggattggag aaagacaaat   1740

gtggaagaaa tcatagagct ggagactact tttgtgcttt acaaaactgt gaaggattgt   1800

ggtcacctgg aacaggtctc caatctatgt tagcactatg tggctcagcc tctgttaccc   1860

cttggattat atatcaacct gtaaacatgt gcctgtaact tacttccaaa aacaaaatca   1920

tacttattag aagaaaattc tgattttata gaaaaaaaat agagcaagga gaatataaca   1980

tgtttgcaaa gtcatgtgtt ttctttctca atgagggaaa aacaatttta ttacctgctt   2040

aatggtccac ctggaactaa aagggatact attttctaac aaggtatatc tagtagggga   2100

gaaagccacc acaataaata tatttgttaa tagtttttca aaaaaaaaaa aaaaaaaaaa   2160

aaaaa                                                               2165


<210>  1862
<211>  272
<212>  PRT
<213>  Homosapiens

<400>  1862

Met His Leu Arg Leu Ile Ser Trp Leu Phe Ile Ile Leu Asn Phe Met 
1               5                   10                  15      


Glu Tyr Ile Gly Ser Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg 
            20                  25                  30          


Met His Pro Asn Val Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys 
        35                  40                  45              


Ser Asp Tyr Asn Gly Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala 
    50                  55                  60                  


Leu Glu Arg Ile Gly Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys 
65                  70                  75                  80  


Pro Ser Gly Tyr Tyr Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr 
                85                  90                  95      


Lys Cys Lys Ala Asp Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr 
            100                 105                 110         


Lys Cys Lys Ser Gly Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn 
        115                 120                 125             


Cys Pro Glu Gly Leu Glu Ala Asn Asn His Thr Met Glu Cys Val Ser 
    130                 135                 140                 


Ile Val His Cys Glu Val Ser Glu Trp Asn Pro Trp Ser Pro Cys Thr 
145                 150                 155                 160 


Lys Lys Gly Lys Thr Cys Gly Phe Lys Arg Gly Thr Glu Thr Arg Val 
                165                 170                 175     


Arg Glu Ile Ile Gln His Pro Ser Ala Lys Gly Asn Leu Cys Pro Pro 
            180                 185                 190         


Thr Asn Glu Thr Arg Lys Cys Thr Val Gln Arg Lys Lys Cys Gln Lys 
        195                 200                 205             


Gly Glu Arg Gly Lys Lys Gly Arg Glu Arg Lys Arg Lys Lys Pro Asn 
    210                 215                 220                 


Lys Gly Glu Ser Lys Glu Ala Ile Pro Asp Ser Lys Ser Leu Glu Ser 
225                 230                 235                 240 


Ser Lys Glu Ile Pro Glu Gln Arg Glu Asn Lys Gln Gln Gln Lys Lys 
                245                 250                 255     


Arg Lys Val Gln Asp Lys Gln Lys Ser Val Ser Val Ser Thr Val His 
            260                 265                 270         


<210>  1863
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1863
cagcgactcc tctggctccc gagaagtgga tccggtcgcg gccactacga tgccgggagc     60

cgccggggtc ctcctccttc tgctgctctc cggaggcctc gggggcgtac aggcgcagcg    120

gccgcagcag cagcggcagt cacaggcaca tcagcaaaga ggtttattcc ctgctgtcct    180

gaatcttgct tctaatgctc ttatcacgac caatgcaaca tgtggagaaa aaggacctga    240

aatgtactgc aaattggtag aacatgtccc tgggcagcct gtgaggaacc cgcagtgtcg    300

aatctgcaat caaaacagca gcaatccaaa ccagagacac ccgattacaa atgctattga    360

tggaaagaac acttggtggc agagtcccag tattaagaat ggaatcgaat accattatgt    420

gacaattaca ctggatttac agcaggtgtt ccagatcgcg tatgtgattg tgaaggcagc    480

taactccccc cggcctggaa actggatttt ggaacgctct cttgatgatg ttgaatacaa    540

gccctggcag tatcatgctg tgacagacac ggagtgccta acgctttaca atatttatcc    600

ccgcactggg ccaccgtcat atgccaaaga tgatgaggtc atctgcactt cattttactc    660

caagatacac cccttagaaa atggagagat tcacatctct ttaatcaatg ggagaccaag    720

tgccgatgat ccttctccag aactgctaga atttacctcc gctcgctata ttcgcctgag    780

atttcagagg atccgcacac tgaatgctga cttgatgatg tttgctcaca aagacccaag    840

agaaattgac cccattgtca ccagaagata ttactactcg gtcaaggata tttcagttgg    900

agggatgtgc atctgctatg gtcatgccag ggcttgtcca cttgatccag cgacaaataa    960

atctcgctgt gagtgtgagc ataacacatg tggcgatagc tgtgatcagt gctgtccagg   1020

attccatcag aaaccctgga gagctggaac ttttctaact aaaactgaat gtgaagcatg   1080

caattgtcat ggaaaagctg aagaatgcta ttatgatgaa aatgttgcca gaagaaatct   1140

gagtttgaat atacgtggaa agtacattgg agggggtgtc tgcattaatt gtacccaaaa   1200

cactgctggt ataaactgcg agacatgtac agatggcttc ttcagaccca aaggggtatc   1260

tccaaattat ccaaggccat gccagccatg tcattgcgat ccaattggtt ccttaaatga   1320

agtctgtgtc aaggatgaga aacatgctcg acgaggtttg gcacctggat cctgtcattg   1380

caaaactggt tttggaggtg tgagctgtga tcggtgtgcc aggggctaca ctggctaccc   1440

ggactgcaaa gcctgtaact gcagtgggtt agggagcaaa aatgaggatc cttgttttgg   1500

cccctgtatc tgcaaggaaa atgttgaagg aggagactgt agtcgttgca aatccggctt   1560

cttcaatttg caagaggata attggaaagg ctgcgatgag tgtttctgtt caggggtttc   1620

aaacagatgt cagagttcct actggaccta tggcaaaata caagatatga gtggctggta   1680

tctgactgac cttcctggcc gcattcgagt ggctccccag caggacgact tggactcacc   1740

tcagcagatc agcatcagta acgcggaggc ccggcaagcc ctgccgcaca gctactactg   1800

gagcgcgccg gctccctatc tgggaaacaa actcccagca gtaggaggac agttgacatt   1860

taccatatca tatgaccttg aagaagagga agaagataca gaacgtgttc tccagcttat   1920

gattatctta gagggtaatg acttgagcat cagcacagcc caagatgagg tgtacctgca   1980

cccatctgaa gaacatacta atgtattgtt acttaaagaa gaatcattta ccatacatgg   2040

cacacatttt ccagtccgta gaaaggaatt tatgacagtg cttgcgaatt tgaagagagt   2100

cctcctacaa atcacataca gctttgggat ggatgccatc ttcaggttga gctctgttaa   2160

ccttgaatcc gctgtctcct atcctactga tggaagcatt gcagcagctg tagaagtgtg   2220

tcagtgccca ccagggtata ctggctcctc ttgtgaatct tgttggccta ggcacaggcg   2280

agttaacggc actatttttg gtggcatctg tgagccatgt cagtgctttg gtcatgcgga   2340

gtcctgtgat gacgtcactg gagaatgcct gaactgtaag gatcacacag gtggcccata   2400

ttgtgataaa tgtcttcctg gtttctatgg cgagcctact aaaggaacct ctgaagactg   2460

tcaaccctgt gcctgtccac tcaatatccc atccaataac tttagcccaa cgtgccattt   2520

agaccggagt cttggattga tctgtgatgg atgccctgtc gggtacacag gaccacgctg   2580

tgagaggtgt gcagaaggct attttggaca accctctgta cctggaggat catgtcagcc   2640

atgccaatgc aatgacaacc ttgacttctc catccctggc agctgtgaca gcttgtctgg   2700

ctcctgtctg atatgtaaac caggtacaac aggccggtac tgtgagctct gtgctgatgg   2760

atattttgga gatgcagttg atgcgaagaa ctgtcagccc tgtcgctgta atgccggtgg   2820

ctctttctct gaggtttgcc acagtcaaac tggacagtgt gagtgcagag ccaacgttca   2880

gggtcagaga tgtgacaaat gcaaggctgg gacctttggc ctacaatcag caaggggctg   2940

tgttccctgc aactgcaatt cttttgggtc taagtcattc gactgtgaag agagtggaca   3000

atgttggtgc caacctggag tcacagggaa gaaatgtgac cgctgtgccc acggctattt   3060

caacttccaa gaaggaggct gcacagcttg tgaatgttct catctgggta ataattgtga   3120

cccaaagact gggcgatgca tttgcccacc caataccatt ggagagaaat gttctaaatg   3180

tgcacccaat acctggggcc acagcattac cactggttgt aaggcttgta actgcagcac   3240

agtgggatcc ttggatttcc aatgcaatgt aaatacaggc caatgcaact gtcatccaaa   3300

attctctggt gcaaaatgta cagagtgcag tcgaggtcac tggaactacc ctcgctgcaa   3360

tctctgtgac tgcttcctcc ctgggacaga tgccacaacc tgtgattcag agactaaaaa   3420

atgctcctgt agtgatcaaa ctgggcagtg cacttgtaag gtgaatgtgg aaggcatcca   3480

ctgtgacaga tgccggcctg gcaaattcgg actcgatgcc aagaatccac ttggctgcag   3540

cagctgctat tgcttcggca ctactaccca gtgctctgaa gcaaaaggac tgatccggac   3600

gtgggtgact ctgaaggctg agcagaccat tctacccctg gtagatgagg ctctgcagca   3660

cacgaccacc aagggcattg tttttcaaca tccagagatt gttgcccaca tggacctgat   3720

gagagaagat ctccatttgg aaccttttta ttggaaactt ccagaacaat ttgaaggaaa   3780

gaagttgatg gcctatgggg gcaaactcaa gtatgcaatc tatttcgagg ctcgggaaga   3840

aacaggtttc tctacatata atcctcaagt gatcattcga ggtgggacac ctactcatgc   3900

tagaattatc gtcaggcata tggctgctcc tctgattggc caattgacaa ggcatgaaat   3960

tgaaatgaca gagaaagaat ggaaatatta tggggatgat cctcgagtcc atagaactgt   4020

gacccgagaa gacttcttgg atatactata tgatattcat tacattctta tcaaagctac   4080

ttatggaaat ttcatgcgac aaagcaggat ttctgaaatc tcaatggagg tagctgaaca   4140

aggacgtgga acaacaatga ctcctccagc tgacttgatt gaaaaatgtg attgtcccct   4200

gggctattct ggcctgtcct gtgaggcatg cttgccggga ttttatcgac tgcgttctca   4260

accaggtggc cgcacccctg gaccaaccct gggcacctgt gttccatgtc aatgtaatgg   4320

acacagcagc ctgtgtgacc ctgaaacatc gatatgccag aattgtcaac atcacactgc   4380

tggtgacttc tgtgaacgat gtgctcttgg atactatgga attgtcaagg gattgccaaa   4440

tgactgtcag caatgtgcct gccctctgat ttcttccagt aacaatttca gcccctcttg   4500

tgtcgcagaa ggacttgacg actaccgctg cacggcttgt ccacggggat atgaaggcca   4560

gtactgtgaa aggtgtgccc ctggctatac tggcagtcca ggcaaccctg gaggctcctg   4620

ccaagaatgt gagtgtgatc cctatggctc actgcctgtg ccctgtgacc ctgtcacagg   4680

attctgcacg tgccgacctg gagccacggg aaggaagtgt gacggctgca agcactggca   4740

tgcacgcgag ggctgggagt gtgttttttg tggagatgag tgcactggcc ttcttctcgg   4800

tgacttggct cgcctggagc agatggtcat gagcatcaac ctcactggtc cgctgcctgc   4860

gccatataaa atgctgtatg gtcttgaaaa tatgactcag gagctaaagc acttgctgtc   4920

acctcagcgg gccccagaga ggcttattca gctggcagag ggcaatctga atacactcgt   4980

gaccgaaatg aacgagctgc tgaccagggc taccaaagtg acagcagatg gcgagcagac   5040

cggacaggat gctgagagga ccaacacaag agcaaagtcc ctgggagaat tcattaagga   5100

gcttgcccgg gatgcagaag ctgtaaatga aaaagctata aaactaaatg aaactctagg   5160

aactcgagac gaggcctttg agagaaattt ggaagggctt cagaaagaga ttgaccagat   5220

gattaaagaa ctgaggagga aaaatctaga gacacaaaag gaaattgctg aagatgagtt   5280

ggtagctgca gaagcccttc tgaaaaaagt gaagaagctg tttggagagt cccgggggga   5340

aaatgaagaa atggagaagg atctccggga aaaactggct gactacaaaa acaaagttga   5400

tgatgcttgg gaccttttga gagaagccac agataaaatc agagaagcta atcgcctatt   5460

tgcagtaaat cagaaaaaca tgactgcatt ggagaaaaag aaggaggctg ttgagagcgg   5520

caaacgacaa attgagaaca ctttaaaaga aggcaatgac atactcgatg aagccaaccg   5580

tcttgcagat gaaatcaact ccatcataga ctatgttgaa gacatccaaa ctaaattgcc   5640

acctatgtct gaggagctta atgataaaat agatgacctc tcccaagaaa taaaggacag   5700

gaagcttgct gagaaggtgt cccaggctga gagccacgca gctcagttga atgactcatc   5760

tgctgtcctt gatggaatcc ttgatgaggc taaaaacatc tccttcaatg ccactgcagc   5820

cttcaaagct tacagcaata ttaaggacta tattgatgaa gctgagaaag ttgccaaaga   5880

agccaaagat cttgcacatg aagctacaaa actggcaaca ggtcctcggg gtttattaaa   5940

ggaagatgcc aaaggctgtc ttcagaaaag cttcaggatt cttaacgaag ccaagaagtt   6000

agcaaatgat gtaaaagaaa atgaagacca tctaaatggc ttaaaaacca ggatagaaaa   6060

tgctgatgct agaaatgggg atctcttgag aactttgaat gacactttgg gaaagttatc   6120

agctattcca aatgatacag ctgctaaact gcaagctgtt aaggacaaag ccagacaagc   6180

caacgacaca gctaaagatg tactggcaca gattacagag ctccaccaga acctcgatgg   6240

cctgaagaag aattacaata aactagcaga cagcgtcgcc aaaacgaatg ctgtggttaa   6300

agatccttcc aagaacaaaa tcattgccga tgcagatgcc actgtcaaaa atttagaaca   6360

ggaagctgac cggctaatag ataaactcaa acccatcaag gaacttgagg ataacctaaa   6420

gaaaaacatc tctgagataa aggaattgat aaaccaagct cggaaacaag ccaattctat   6480

caaagtatct gtgtcttcag gaggtgactg cattcgaaca tacaaaccag aaatcaagaa   6540

aggaagttac aataatattg ttgtcaacgt aaagacagct gttgctgata acctcctctt   6600

ttatcttgga agtgccaaat ttattgactt tctggctata gaaatgcgta aaggcaaagt   6660

cagcttcctc tgggatgttg gatctggagt tggacgtgta gagtacccag atttgactat   6720

tgatgactca tattggtacc gtatcgtagc atcaagaact gggagaaatg gaactatttc   6780

tgtgagagcc ctggatggac ccaaagccag cattgtgccc agcacacacc attcgacgtc   6840

tcctccaggg tacacgattc tagatgtgga tgcaaatgca atgctgtttg ttggtggcct   6900

gactgggaaa ttaaagaagg ctgatgctgt acgtgtgatt acattcactg gctgcatggg   6960

agaaacatac tttgacaaca aacctatagg tttgtggaat ttccgagaaa aagaaggtga   7020

ctgcaaagga tgcactgtca gtcctcaggt ggaagatagt gaggggacta ttcaatttga   7080

tggagaaggt tatgcattgg tcagccgtcc cattcgctgg taccccaaca tctccactgt   7140

catgttcaag ttcagaacat tttcttcgag tgctcttctg atgtatcttg ccacacgaga   7200

cctgagagat ttcatgagtg tggagctcac tgatgggcac ataaaagtca gttacgatct   7260

gggctcagga atggcttccg ttgtcagcaa tcaaaaccat aatgatggga aatggaaatc   7320

attcactctg tcaagaattc aaaaacaagc caatatatca attgtagata tagatactaa   7380

tcaggaggag aatatagcaa cttcgtcttc tggaaacaac tttggtcttg acttgaaagc   7440

agatgacaaa atatattttg gtggcctgcc aacgctgaga aacttgagta tgaaagcaag   7500

gccagaagta aatctgaaga aatattccgg ctgcctcaaa gatattgaaa tttcaagaac   7560

tccgtacaat atactcagta gtcccgatta tgttggtgtt accaaaggat gttccctgga   7620

gaatgtttac acagttagct ttcctaagcc tggttttgtg gagctctccc ctgtgccaat   7680

tgatgtagga acagaaatca acctgtcatt cagcaccaag aatgagtccg gcatcattct   7740

tttgggaagt ggagggacac cagcaccacc taggagaaaa cgaaggcaga ctggacaggc   7800

ctattatgta atactcctca acaggggccg tctggaagtg catctctcca caggggcacg   7860

aacaatgagg aaaattgtca tcagaccaga gccgaatctg tttcatgatg gaagagaaca   7920

ttccgttcat gtagagcgaa ctagaggcat ctttacagtt caagtggatg aaaacagaag   7980

atacatgcaa aacctgacag ttgaacagcc tatcgaagtt aaaaagcttt tcgttggggg   8040

tgctccacct gaatttcaac cttccccact cagaaatatt cctccttttg aaggctgcat   8100

atggaatctt gttattaact ctgtccccat ggactttgca aggcctgtgt ccttcaaaaa   8160

tgctgacatt ggtcgctgtg cccatcagaa ac                                 8192


<210>  1864
<211>  3122
<212>  PRT
<213>  Homosapiens

<400>  1864

Met Pro Gly Ala Ala Gly Val Leu Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Gly Gly Val Gln Ala Gln Arg Pro Gln Gln Gln Arg Gln Ser Gln 
            20                  25                  30          


Ala His Gln Gln Arg Gly Leu Phe Pro Ala Val Leu Asn Leu Ala Ser 
        35                  40                  45              


Asn Ala Leu Ile Thr Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu 
    50                  55                  60                  


Met Tyr Cys Lys Leu Val Glu His Val Pro Gly Gln Pro Val Arg Asn 
65                  70                  75                  80  


Pro Gln Cys Arg Ile Cys Asn Gln Asn Ser Ser Asn Pro Asn Gln Arg 
                85                  90                  95      


His Pro Ile Thr Asn Ala Ile Asp Gly Lys Asn Thr Trp Trp Gln Ser 
            100                 105                 110         


Pro Ser Ile Lys Asn Gly Ile Glu Tyr His Tyr Val Thr Ile Thr Leu 
        115                 120                 125             


Asp Leu Gln Gln Val Phe Gln Ile Ala Tyr Val Ile Val Lys Ala Ala 
    130                 135                 140                 


Asn Ser Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Asp 
145                 150                 155                 160 


Val Glu Tyr Lys Pro Trp Gln Tyr His Ala Val Thr Asp Thr Glu Cys 
                165                 170                 175     


Leu Thr Leu Tyr Asn Ile Tyr Pro Arg Thr Gly Pro Pro Ser Tyr Ala 
            180                 185                 190         


Lys Asp Asp Glu Val Ile Cys Thr Ser Phe Tyr Ser Lys Ile His Pro 
        195                 200                 205             


Leu Glu Asn Gly Glu Ile His Ile Ser Leu Ile Asn Gly Arg Pro Ser 
    210                 215                 220                 


Ala Asp Asp Pro Ser Pro Glu Leu Leu Glu Phe Thr Ser Ala Arg Tyr 
225                 230                 235                 240 


Ile Arg Leu Arg Phe Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met 
                245                 250                 255     


Met Phe Ala His Lys Asp Pro Arg Glu Ile Asp Pro Ile Val Thr Arg 
            260                 265                 270         


Arg Tyr Tyr Tyr Ser Val Lys Asp Ile Ser Val Gly Gly Met Cys Ile 
        275                 280                 285             


Cys Tyr Gly His Ala Arg Ala Cys Pro Leu Asp Pro Ala Thr Asn Lys 
    290                 295                 300                 


Ser Arg Cys Glu Cys Glu His Asn Thr Cys Gly Asp Ser Cys Asp Gln 
305                 310                 315                 320 


Cys Cys Pro Gly Phe His Gln Lys Pro Trp Arg Ala Gly Thr Phe Leu 
                325                 330                 335     


Thr Lys Thr Glu Cys Glu Ala Cys Asn Cys His Gly Lys Ala Glu Glu 
            340                 345                 350         


Cys Tyr Tyr Asp Glu Asn Val Ala Arg Arg Asn Leu Ser Leu Asn Ile 
        355                 360                 365             


Arg Gly Lys Tyr Ile Gly Gly Gly Val Cys Ile Asn Cys Thr Gln Asn 
    370                 375                 380                 


Thr Ala Gly Ile Asn Cys Glu Thr Cys Thr Asp Gly Phe Phe Arg Pro 
385                 390                 395                 400 


Lys Gly Val Ser Pro Asn Tyr Pro Arg Pro Cys Gln Pro Cys His Cys 
                405                 410                 415     


Asp Pro Ile Gly Ser Leu Asn Glu Val Cys Val Lys Asp Glu Lys His 
            420                 425                 430         


Ala Arg Arg Gly Leu Ala Pro Gly Ser Cys His Cys Lys Thr Gly Phe 
        435                 440                 445             


Gly Gly Val Ser Cys Asp Arg Cys Ala Arg Gly Tyr Thr Gly Tyr Pro 
    450                 455                 460                 


Asp Cys Lys Ala Cys Asn Cys Ser Gly Leu Gly Ser Lys Asn Glu Asp 
465                 470                 475                 480 


Pro Cys Phe Gly Pro Cys Ile Cys Lys Glu Asn Val Glu Gly Gly Asp 
                485                 490                 495     


Cys Ser Arg Cys Lys Ser Gly Phe Phe Asn Leu Gln Glu Asp Asn Trp 
            500                 505                 510         


Lys Gly Cys Asp Glu Cys Phe Cys Ser Gly Val Ser Asn Arg Cys Gln 
        515                 520                 525             


Ser Ser Tyr Trp Thr Tyr Gly Lys Ile Gln Asp Met Ser Gly Trp Tyr 
    530                 535                 540                 


Leu Thr Asp Leu Pro Gly Arg Ile Arg Val Ala Pro Gln Gln Asp Asp 
545                 550                 555                 560 


Leu Asp Ser Pro Gln Gln Ile Ser Ile Ser Asn Ala Glu Ala Arg Gln 
                565                 570                 575     


Ala Leu Pro His Ser Tyr Tyr Trp Ser Ala Pro Ala Pro Tyr Leu Gly 
            580                 585                 590         


Asn Lys Leu Pro Ala Val Gly Gly Gln Leu Thr Phe Thr Ile Ser Tyr 
        595                 600                 605             


Asp Leu Glu Glu Glu Glu Glu Asp Thr Glu Arg Val Leu Gln Leu Met 
    610                 615                 620                 


Ile Ile Leu Glu Gly Asn Asp Leu Ser Ile Ser Thr Ala Gln Asp Glu 
625                 630                 635                 640 


Val Tyr Leu His Pro Ser Glu Glu His Thr Asn Val Leu Leu Leu Lys 
                645                 650                 655     


Glu Glu Ser Phe Thr Ile His Gly Thr His Phe Pro Val Arg Arg Lys 
            660                 665                 670         


Glu Phe Met Thr Val Leu Ala Asn Leu Lys Arg Val Leu Leu Gln Ile 
        675                 680                 685             


Thr Tyr Ser Phe Gly Met Asp Ala Ile Phe Arg Leu Ser Ser Val Asn 
    690                 695                 700                 


Leu Glu Ser Ala Val Ser Tyr Pro Thr Asp Gly Ser Ile Ala Ala Ala 
705                 710                 715                 720 


Val Glu Val Cys Gln Cys Pro Pro Gly Tyr Thr Gly Ser Ser Cys Glu 
                725                 730                 735     


Ser Cys Trp Pro Arg His Arg Arg Val Asn Gly Thr Ile Phe Gly Gly 
            740                 745                 750         


Ile Cys Glu Pro Cys Gln Cys Phe Gly His Ala Glu Ser Cys Asp Asp 
        755                 760                 765             


Val Thr Gly Glu Cys Leu Asn Cys Lys Asp His Thr Gly Gly Pro Tyr 
    770                 775                 780                 


Cys Asp Lys Cys Leu Pro Gly Phe Tyr Gly Glu Pro Thr Lys Gly Thr 
785                 790                 795                 800 


Ser Glu Asp Cys Gln Pro Cys Ala Cys Pro Leu Asn Ile Pro Ser Asn 
                805                 810                 815     


Asn Phe Ser Pro Thr Cys His Leu Asp Arg Ser Leu Gly Leu Ile Cys 
            820                 825                 830         


Asp Gly Cys Pro Val Gly Tyr Thr Gly Pro Arg Cys Glu Arg Cys Ala 
        835                 840                 845             


Glu Gly Tyr Phe Gly Gln Pro Ser Val Pro Gly Gly Ser Cys Gln Pro 
    850                 855                 860                 


Cys Gln Cys Asn Asp Asn Leu Asp Phe Ser Ile Pro Gly Ser Cys Asp 
865                 870                 875                 880 


Ser Leu Ser Gly Ser Cys Leu Ile Cys Lys Pro Gly Thr Thr Gly Arg 
                885                 890                 895     


Tyr Cys Glu Leu Cys Ala Asp Gly Tyr Phe Gly Asp Ala Val Asp Ala 
            900                 905                 910         


Lys Asn Cys Gln Pro Cys Arg Cys Asn Ala Gly Gly Ser Phe Ser Glu 
        915                 920                 925             


Val Cys His Ser Gln Thr Gly Gln Cys Glu Cys Arg Ala Asn Val Gln 
    930                 935                 940                 


Gly Gln Arg Cys Asp Lys Cys Lys Ala Gly Thr Phe Gly Leu Gln Ser 
945                 950                 955                 960 


Ala Arg Gly Cys Val Pro Cys Asn Cys Asn Ser Phe Gly Ser Lys Ser 
                965                 970                 975     


Phe Asp Cys Glu Glu Ser Gly Gln Cys Trp Cys Gln Pro Gly Val Thr 
            980                 985                 990         


Gly Lys Lys Cys Asp Arg Cys Ala  His Gly Tyr Phe Asn  Phe Gln Glu 
        995                 1000                 1005             


Gly Gly  Cys Thr Ala Cys Glu  Cys Ser His Leu Gly  Asn Asn Cys 
    1010                 1015                 1020             


Asp Pro  Lys Thr Gly Arg Cys  Ile Cys Pro Pro Asn  Thr Ile Gly 
    1025                 1030                 1035             


Glu Lys  Cys Ser Lys Cys Ala  Pro Asn Thr Trp Gly  His Ser Ile 
    1040                 1045                 1050             


Thr Thr  Gly Cys Lys Ala Cys  Asn Cys Ser Thr Val  Gly Ser Leu 
    1055                 1060                 1065             


Asp Phe  Gln Cys Asn Val Asn  Thr Gly Gln Cys Asn  Cys His Pro 
    1070                 1075                 1080             


Lys Phe  Ser Gly Ala Lys Cys  Thr Glu Cys Ser Arg  Gly His Trp 
    1085                 1090                 1095             


Asn Tyr  Pro Arg Cys Asn Leu  Cys Asp Cys Phe Leu  Pro Gly Thr 
    1100                 1105                 1110             


Asp Ala  Thr Thr Cys Asp Ser  Glu Thr Lys Lys Cys  Ser Cys Ser 
    1115                 1120                 1125             


Asp Gln  Thr Gly Gln Cys Thr  Cys Lys Val Asn Val  Glu Gly Ile 
    1130                 1135                 1140             


His Cys  Asp Arg Cys Arg Pro  Gly Lys Phe Gly Leu  Asp Ala Lys 
    1145                 1150                 1155             


Asn Pro  Leu Gly Cys Ser Ser  Cys Tyr Cys Phe Gly  Thr Thr Thr 
    1160                 1165                 1170             


Gln Cys  Ser Glu Ala Lys Gly  Leu Ile Arg Thr Trp  Val Thr Leu 
    1175                 1180                 1185             


Lys Ala  Glu Gln Thr Ile Leu  Pro Leu Val Asp Glu  Ala Leu Gln 
    1190                 1195                 1200             


His Thr  Thr Thr Lys Gly Ile  Val Phe Gln His Pro  Glu Ile Val 
    1205                 1210                 1215             


Ala His  Met Asp Leu Met Arg  Glu Asp Leu His Leu  Glu Pro Phe 
    1220                 1225                 1230             


Tyr Trp  Lys Leu Pro Glu Gln  Phe Glu Gly Lys Lys  Leu Met Ala 
    1235                 1240                 1245             


Tyr Gly  Gly Lys Leu Lys Tyr  Ala Ile Tyr Phe Glu  Ala Arg Glu 
    1250                 1255                 1260             


Glu Thr  Gly Phe Ser Thr Tyr  Asn Pro Gln Val Ile  Ile Arg Gly 
    1265                 1270                 1275             


Gly Thr  Pro Thr His Ala Arg  Ile Ile Val Arg His  Met Ala Ala 
    1280                 1285                 1290             


Pro Leu  Ile Gly Gln Leu Thr  Arg His Glu Ile Glu  Met Thr Glu 
    1295                 1300                 1305             


Lys Glu  Trp Lys Tyr Tyr Gly  Asp Asp Pro Arg Val  His Arg Thr 
    1310                 1315                 1320             


Val Thr  Arg Glu Asp Phe Leu  Asp Ile Leu Tyr Asp  Ile His Tyr 
    1325                 1330                 1335             


Ile Leu  Ile Lys Ala Thr Tyr  Gly Asn Phe Met Arg  Gln Ser Arg 
    1340                 1345                 1350             


Ile Ser  Glu Ile Ser Met Glu  Val Ala Glu Gln Gly  Arg Gly Thr 
    1355                 1360                 1365             


Thr Met  Thr Pro Pro Ala Asp  Leu Ile Glu Lys Cys  Asp Cys Pro 
    1370                 1375                 1380             


Leu Gly  Tyr Ser Gly Leu Ser  Cys Glu Ala Cys Leu  Pro Gly Phe 
    1385                 1390                 1395             


Tyr Arg  Leu Arg Ser Gln Pro  Gly Gly Arg Thr Pro  Gly Pro Thr 
    1400                 1405                 1410             


Leu Gly  Thr Cys Val Pro Cys  Gln Cys Asn Gly His  Ser Ser Leu 
    1415                 1420                 1425             


Cys Asp  Pro Glu Thr Ser Ile  Cys Gln Asn Cys Gln  His His Thr 
    1430                 1435                 1440             


Ala Gly  Asp Phe Cys Glu Arg  Cys Ala Leu Gly Tyr  Tyr Gly Ile 
    1445                 1450                 1455             


Val Lys  Gly Leu Pro Asn Asp  Cys Gln Gln Cys Ala  Cys Pro Leu 
    1460                 1465                 1470             


Ile Ser  Ser Ser Asn Asn Phe  Ser Pro Ser Cys Val  Ala Glu Gly 
    1475                 1480                 1485             


Leu Asp  Asp Tyr Arg Cys Thr  Ala Cys Pro Arg Gly  Tyr Glu Gly 
    1490                 1495                 1500             


Gln Tyr  Cys Glu Arg Cys Ala  Pro Gly Tyr Thr Gly  Ser Pro Gly 
    1505                 1510                 1515             


Asn Pro  Gly Gly Ser Cys Gln  Glu Cys Glu Cys Asp  Pro Tyr Gly 
    1520                 1525                 1530             


Ser Leu  Pro Val Pro Cys Asp  Pro Val Thr Gly Phe  Cys Thr Cys 
    1535                 1540                 1545             


Arg Pro  Gly Ala Thr Gly Arg  Lys Cys Asp Gly Cys  Lys His Trp 
    1550                 1555                 1560             


His Ala  Arg Glu Gly Trp Glu  Cys Val Phe Cys Gly  Asp Glu Cys 
    1565                 1570                 1575             


Thr Gly  Leu Leu Leu Gly Asp  Leu Ala Arg Leu Glu  Gln Met Val 
    1580                 1585                 1590             


Met Ser  Ile Asn Leu Thr Gly  Pro Leu Pro Ala Pro  Tyr Lys Met 
    1595                 1600                 1605             


Leu Tyr  Gly Leu Glu Asn Met  Thr Gln Glu Leu Lys  His Leu Leu 
    1610                 1615                 1620             


Ser Pro  Gln Arg Ala Pro Glu  Arg Leu Ile Gln Leu  Ala Glu Gly 
    1625                 1630                 1635             


Asn Leu  Asn Thr Leu Val Thr  Glu Met Asn Glu Leu  Leu Thr Arg 
    1640                 1645                 1650             


Ala Thr  Lys Val Thr Ala Asp  Gly Glu Gln Thr Gly  Gln Asp Ala 
    1655                 1660                 1665             


Glu Arg  Thr Asn Thr Arg Ala  Lys Ser Leu Gly Glu  Phe Ile Lys 
    1670                 1675                 1680             


Glu Leu  Ala Arg Asp Ala Glu  Ala Val Asn Glu Lys  Ala Ile Lys 
    1685                 1690                 1695             


Leu Asn  Glu Thr Leu Gly Thr  Arg Asp Glu Ala Phe  Glu Arg Asn 
    1700                 1705                 1710             


Leu Glu  Gly Leu Gln Lys Glu  Ile Asp Gln Met Ile  Lys Glu Leu 
    1715                 1720                 1725             


Arg Arg  Lys Asn Leu Glu Thr  Gln Lys Glu Ile Ala  Glu Asp Glu 
    1730                 1735                 1740             


Leu Val  Ala Ala Glu Ala Leu  Leu Lys Lys Val Lys  Lys Leu Phe 
    1745                 1750                 1755             


Gly Glu  Ser Arg Gly Glu Asn  Glu Glu Met Glu Lys  Asp Leu Arg 
    1760                 1765                 1770             


Glu Lys  Leu Ala Asp Tyr Lys  Asn Lys Val Asp Asp  Ala Trp Asp 
    1775                 1780                 1785             


Leu Leu  Arg Glu Ala Thr Asp  Lys Ile Arg Glu Ala  Asn Arg Leu 
    1790                 1795                 1800             


Phe Ala  Val Asn Gln Lys Asn  Met Thr Ala Leu Glu  Lys Lys Lys 
    1805                 1810                 1815             


Glu Ala  Val Glu Ser Gly Lys  Arg Gln Ile Glu Asn  Thr Leu Lys 
    1820                 1825                 1830             


Glu Gly  Asn Asp Ile Leu Asp  Glu Ala Asn Arg Leu  Ala Asp Glu 
    1835                 1840                 1845             


Ile Asn  Ser Ile Ile Asp Tyr  Val Glu Asp Ile Gln  Thr Lys Leu 
    1850                 1855                 1860             


Pro Pro  Met Ser Glu Glu Leu  Asn Asp Lys Ile Asp  Asp Leu Ser 
    1865                 1870                 1875             


Gln Glu  Ile Lys Asp Arg Lys  Leu Ala Glu Lys Val  Ser Gln Ala 
    1880                 1885                 1890             


Glu Ser  His Ala Ala Gln Leu  Asn Asp Ser Ser Ala  Val Leu Asp 
    1895                 1900                 1905             


Gly Ile  Leu Asp Glu Ala Lys  Asn Ile Ser Phe Asn  Ala Thr Ala 
    1910                 1915                 1920             


Ala Phe  Lys Ala Tyr Ser Asn  Ile Lys Asp Tyr Ile  Asp Glu Ala 
    1925                 1930                 1935             


Glu Lys  Val Ala Lys Glu Ala  Lys Asp Leu Ala His  Glu Ala Thr 
    1940                 1945                 1950             


Lys Leu  Ala Thr Gly Pro Arg  Gly Leu Leu Lys Glu  Asp Ala Lys 
    1955                 1960                 1965             


Gly Cys  Leu Gln Lys Ser Phe  Arg Ile Leu Asn Glu  Ala Lys Lys 
    1970                 1975                 1980             


Leu Ala  Asn Asp Val Lys Glu  Asn Glu Asp His Leu  Asn Gly Leu 
    1985                 1990                 1995             


Lys Thr  Arg Ile Glu Asn Ala  Asp Ala Arg Asn Gly  Asp Leu Leu 
    2000                 2005                 2010             


Arg Thr  Leu Asn Asp Thr Leu  Gly Lys Leu Ser Ala  Ile Pro Asn 
    2015                 2020                 2025             


Asp Thr  Ala Ala Lys Leu Gln  Ala Val Lys Asp Lys  Ala Arg Gln 
    2030                 2035                 2040             


Ala Asn  Asp Thr Ala Lys Asp  Val Leu Ala Gln Ile  Thr Glu Leu 
    2045                 2050                 2055             


His Gln  Asn Leu Asp Gly Leu  Lys Lys Asn Tyr Asn  Lys Leu Ala 
    2060                 2065                 2070             


Asp Ser  Val Ala Lys Thr Asn  Ala Val Val Lys Asp  Pro Ser Lys 
    2075                 2080                 2085             


Asn Lys  Ile Ile Ala Asp Ala  Asp Ala Thr Val Lys  Asn Leu Glu 
    2090                 2095                 2100             


Gln Glu  Ala Asp Arg Leu Ile  Asp Lys Leu Lys Pro  Ile Lys Glu 
    2105                 2110                 2115             


Leu Glu  Asp Asn Leu Lys Lys  Asn Ile Ser Glu Ile  Lys Glu Leu 
    2120                 2125                 2130             


Ile Asn  Gln Ala Arg Lys Gln  Ala Asn Ser Ile Lys  Val Ser Val 
    2135                 2140                 2145             


Ser Ser  Gly Gly Asp Cys Ile  Arg Thr Tyr Lys Pro  Glu Ile Lys 
    2150                 2155                 2160             


Lys Gly  Ser Tyr Asn Asn Ile  Val Val Asn Val Lys  Thr Ala Val 
    2165                 2170                 2175             


Ala Asp  Asn Leu Leu Phe Tyr  Leu Gly Ser Ala Lys  Phe Ile Asp 
    2180                 2185                 2190             


Phe Leu  Ala Ile Glu Met Arg  Lys Gly Lys Val Ser  Phe Leu Trp 
    2195                 2200                 2205             


Asp Val  Gly Ser Gly Val Gly  Arg Val Glu Tyr Pro  Asp Leu Thr 
    2210                 2215                 2220             


Ile Asp  Asp Ser Tyr Trp Tyr  Arg Ile Val Ala Ser  Arg Thr Gly 
    2225                 2230                 2235             


Arg Asn  Gly Thr Ile Ser Val  Arg Ala Leu Asp Gly  Pro Lys Ala 
    2240                 2245                 2250             


Ser Ile  Val Pro Ser Thr His  His Ser Thr Ser Pro  Pro Gly Tyr 
    2255                 2260                 2265             


Thr Ile  Leu Asp Val Asp Ala  Asn Ala Met Leu Phe  Val Gly Gly 
    2270                 2275                 2280             


Leu Thr  Gly Lys Leu Lys Lys  Ala Asp Ala Val Arg  Val Ile Thr 
    2285                 2290                 2295             


Phe Thr  Gly Cys Met Gly Glu  Thr Tyr Phe Asp Asn  Lys Pro Ile 
    2300                 2305                 2310             


Gly Leu  Trp Asn Phe Arg Glu  Lys Glu Gly Asp Cys  Lys Gly Cys 
    2315                 2320                 2325             


Thr Val  Ser Pro Gln Val Glu  Asp Ser Glu Gly Thr  Ile Gln Phe 
    2330                 2335                 2340             


Asp Gly  Glu Gly Tyr Ala Leu  Val Ser Arg Pro Ile  Arg Trp Tyr 
    2345                 2350                 2355             


Pro Asn  Ile Ser Thr Val Met  Phe Lys Phe Arg Thr  Phe Ser Ser 
    2360                 2365                 2370             


Ser Ala  Leu Leu Met Tyr Leu  Ala Thr Arg Asp Leu  Arg Asp Phe 
    2375                 2380                 2385             


Met Ser  Val Glu Leu Thr Asp  Gly His Ile Lys Val  Ser Tyr Asp 
    2390                 2395                 2400             


Leu Gly  Ser Gly Met Ala Ser  Val Val Ser Asn Gln  Asn His Asn 
    2405                 2410                 2415             


Asp Gly  Lys Trp Lys Ser Phe  Thr Leu Ser Arg Ile  Gln Lys Gln 
    2420                 2425                 2430             


Ala Asn  Ile Ser Ile Val Asp  Ile Asp Thr Asn Gln  Glu Glu Asn 
    2435                 2440                 2445             


Ile Ala  Thr Ser Ser Ser Gly  Asn Asn Phe Gly Leu  Asp Leu Lys 
    2450                 2455                 2460             


Ala Asp  Asp Lys Ile Tyr Phe  Gly Gly Leu Pro Thr  Leu Arg Asn 
    2465                 2470                 2475             


Leu Ser  Met Lys Ala Arg Pro  Glu Val Asn Leu Lys  Lys Tyr Ser 
    2480                 2485                 2490             


Gly Cys  Leu Lys Asp Ile Glu  Ile Ser Arg Thr Pro  Tyr Asn Ile 
    2495                 2500                 2505             


Leu Ser  Ser Pro Asp Tyr Val  Gly Val Thr Lys Gly  Cys Ser Leu 
    2510                 2515                 2520             


Glu Asn  Val Tyr Thr Val Ser  Phe Pro Lys Pro Gly  Phe Val Glu 
    2525                 2530                 2535             


Leu Ser  Pro Val Pro Ile Asp  Val Gly Thr Glu Ile  Asn Leu Ser 
    2540                 2545                 2550             


Phe Ser  Thr Lys Asn Glu Ser  Gly Ile Ile Leu Leu  Gly Ser Gly 
    2555                 2560                 2565             


Gly Thr  Pro Ala Pro Pro Arg  Arg Lys Arg Arg Gln  Thr Gly Gln 
    2570                 2575                 2580             


Ala Tyr  Tyr Val Ile Leu Leu  Asn Arg Gly Arg Leu  Glu Val His 
    2585                 2590                 2595             


Leu Ser  Thr Gly Ala Arg Thr  Met Arg Lys Ile Val  Ile Arg Pro 
    2600                 2605                 2610             


Glu Pro  Asn Leu Phe His Asp  Gly Arg Glu His Ser  Val His Val 
    2615                 2620                 2625             


Glu Arg  Thr Arg Gly Ile Phe  Thr Val Gln Val Asp  Glu Asn Arg 
    2630                 2635                 2640             


Arg Tyr  Met Gln Asn Leu Thr  Val Glu Gln Pro Ile  Glu Val Lys 
    2645                 2650                 2655             


Lys Leu  Phe Val Gly Gly Ala  Pro Pro Glu Phe Gln  Pro Ser Pro 
    2660                 2665                 2670             


Leu Arg  Asn Ile Pro Pro Phe  Glu Gly Cys Ile Trp  Asn Leu Val 
    2675                 2680                 2685             


Ile Asn  Ser Val Pro Met Asp  Phe Ala Arg Pro Val  Ser Phe Lys 
    2690                 2695                 2700             


Asn Ala  Asp Ile Gly Arg Cys  Ala His Gln Lys Leu  Arg Glu Asp 
    2705                 2710                 2715             


Glu Asp  Gly Ala Ala Pro Ala  Glu Ile Val Ile Gln  Pro Glu Pro 
    2720                 2725                 2730             


Val Pro  Thr Pro Ala Phe Pro  Thr Pro Thr Pro Val  Leu Thr His 
    2735                 2740                 2745             


Gly Pro  Cys Ala Ala Glu Ser  Glu Pro Ala Leu Leu  Ile Gly Ser 
    2750                 2755                 2760             


Lys Gln  Phe Gly Leu Ser Arg  Asn Ser His Ile Ala  Ile Ala Phe 
    2765                 2770                 2775             


Asp Asp  Thr Lys Val Lys Asn  Arg Leu Thr Ile Glu  Leu Glu Val 
    2780                 2785                 2790             


Arg Thr  Glu Ala Glu Ser Gly  Leu Leu Phe Tyr Met  Ala Arg Ile 
    2795                 2800                 2805             


Asn His  Ala Asp Phe Ala Thr  Val Gln Leu Arg Asn  Gly Leu Pro 
    2810                 2815                 2820             


Tyr Phe  Ser Tyr Asp Leu Gly  Ser Gly Asp Thr His  Thr Met Ile 
    2825                 2830                 2835             


Pro Thr  Lys Ile Asn Asp Gly  Gln Trp His Lys Ile  Lys Ile Met 
    2840                 2845                 2850             


Arg Ser  Lys Gln Glu Gly Ile  Leu Tyr Val Asp Gly  Ala Ser Asn 
    2855                 2860                 2865             


Arg Thr  Ile Ser Pro Lys Lys  Ala Asp Ile Leu Asp  Val Val Gly 
    2870                 2875                 2880             


Met Leu  Tyr Val Gly Gly Leu  Pro Ile Asn Tyr Thr  Thr Arg Arg 
    2885                 2890                 2895             


Ile Gly  Pro Val Thr Tyr Ser  Ile Asp Gly Cys Val  Arg Asn Leu 
    2900                 2905                 2910             


His Met  Ala Glu Ala Pro Ala  Asp Leu Glu Gln Pro  Thr Ser Ser 
    2915                 2920                 2925             


Phe His  Val Gly Thr Cys Phe  Ala Asn Ala Gln Arg  Gly Thr Tyr 
    2930                 2935                 2940             


Phe Asp  Gly Thr Gly Phe Ala  Lys Ala Val Gly Gly  Phe Lys Val 
    2945                 2950                 2955             


Gly Leu  Asp Leu Leu Val Glu  Phe Glu Phe Arg Thr  Thr Thr Thr 
    2960                 2965                 2970             


Thr Gly  Val Leu Leu Gly Ile  Ser Ser Gln Lys Met  Asp Gly Met 
    2975                 2980                 2985             


Gly Ile  Glu Met Ile Asp Glu  Lys Leu Met Phe His  Val Asp Asn 
    2990                 2995                 3000             


Gly Ala  Gly Arg Phe Thr Ala  Val Tyr Asp Ala Gly  Val Pro Gly 
    3005                 3010                 3015             


His Leu  Cys Asp Gly Gln Trp  His Lys Val Thr Ala  Asn Lys Ile 
    3020                 3025                 3030             


Lys His  Arg Ile Glu Leu Thr  Val Asp Gly Asn Gln  Val Glu Ala 
    3035                 3040                 3045             


Gln Ser  Pro Asn Pro Ala Ser  Thr Ser Ala Asp Thr  Asn Asp Pro 
    3050                 3055                 3060             


Val Phe  Val Gly Gly Phe Pro  Asp Asp Leu Lys Gln  Phe Gly Leu 
    3065                 3070                 3075             


Thr Thr  Ser Ile Pro Phe Arg  Gly Cys Ile Arg Ser  Leu Lys Leu 
    3080                 3085                 3090             


Thr Lys  Gly Thr Gly Lys Pro  Leu Glu Val Asn Phe  Ala Lys Ala 
    3095                 3100                 3105             


Leu Glu  Leu Arg Gly Val Gln  Pro Val Ser Cys Pro  Ala Asn 
    3110                 3115                 3120         


<210>  1865
<211>  5042
<212>  DNA
<213>  Homosapiens

<400>  1865
gcaagcattt aggaatagca tttgccaact cccaagactt ggctgtccct ctcgctctgg     60

ccttacttac ctaactgacc tcctgtagta ctgagttgtg tgctggccaa gttcctattc    120

ctggactgct ttctttccct tgaccttcct tgaaatactg ctaacctgac ttttgactgt    180

gatctatgtg ctatctcctg tgtgaagcct aatgaaaggt ccttctctaa tggaaacttt    240

cattctagga gttacctcat tctgttttat gtggatctgt tagctccttc attaggtttc    300

aagctgtttg aaacagtgat tgaatttgct cacctttgct ttcctctcag ggtctacatt    360

gggaccctga gtgataatag agccttctgt agtattgaat tgctttaaac agaattaaag    420

gacattggca ccaaatgtga ttttgccaat ccttgggagt cttggtgcct ctgtctgggc    480

ttgaccaggg tagaatggct gaagaaaatg tgattcctcc acccattaaa ttctttattt    540

ctcaactact ctggaagttt ttgcctcttt ttgtttctat ccattttcat acttttaaga    600

tacccttttt tactttaaga tacctttttt cttcctaacg tttctttaca tgctcacatg    660

caagcccagt catccatctc tctttttcac ctttctgtcc tcatatattt ttcttaaaat    720

atcttttctc atctaatctc ctttcctcta tcaatcagcc tcctaagcga aaatggtagt    780

gctaatgttt taaaaagtgg gggaggacta gaaatctgta tggaatgtaa ttcactttta    840

ttgcttttaa attaaatgaa acgtttttgc ccttgtttcc attctactca gaaggatttc    900

agactaaatc cttaagcctg ccatatggaa ataactgggc tagagggctg ctatctaatc    960

taagcattta attcaaacat ttgaaatggt ttttgcttca agaaaacata ggttgacact   1020

aagctttatt ttagcaaagg tttgggaaag gttctaatct gcagtatgta cactttgata   1080

aatttcatag actagagcaa cagattacaa tttagtttgt tcttccaaca taaaactatt   1140

ttaatcctag ttataatttc actgaaggct ggatttactc actggcttgt taaaactgta   1200

gataacaacc acaagcctgt tatttaaaca caattcagaa atcataaata gaaattcaaa   1260

aggagagctc aatgctgcaa gatgagattt gatgccctga agaaactctc tctgaaattt   1320

gccaaagacc ttgtggaact taaaatatct tcttgtttcc taccagctag atatggcagc   1380

ttgagaacta tttattatga atcaagatag atattttacc aactcagaaa atgttgcttt   1440

ttgtttggat attaatcttg tttgttcata tttttaacta ggaaagttag tacagtaata   1500

tggtggtcat ccaacagacc acaagaagag aatttgtccc tcattcagca ttttagcaaa   1560

tatttcttga acactagcca tgtgcaaggt attacagtga gtgtttctgc taataaaaat   1620

atgaattaaa tttgatgttt gatcataagt agaagaactg tgatactata atattgtaag   1680

tgccatagaa aacttgctat tataaaatgc tgtaaggagt taatgcttgc atagggtgca   1740

gtgggtcagc tagagaaggc tttataaaga aagtggaata tgagctttga tgcctagcca   1800

gatgtgggta tgtgaagaac agggcagggc agtggggagt gggtggattc tggacagctg   1860

aaacattgtt aacaaaatct cagaaatggt acaaaatgga atatgaatga gaaatacaga   1920

acatttgtta ggttttattt ttatgcaaat taaagagaag agttagagac aaagttaaag   1980

tcaatgggtc tagaatttca gctaaaactt tggtaggtag tggagaatat tttatcatta   2040

ttctgctctt taaacaactt cagagatgat tgattaatct tgattgtaaa ggaagagaaa   2100

ttctttggaa gaccagttag ggggttatca tatggtctag taaaagttaa taagatctgc   2160

acaaggctgg gaagagtagg attagaacag aggggtggaa ttaaaggaca tcgtatattg   2220

gaaatttcta ggatttagaa cctgattgga agaggaagaa gaaagggagg agttaaaaat   2280

aactgtaaag agccaaatct gagaactgac cctgctaaaa aagtcagaca agtcaagtgg   2340

tgcagctggt gtgtgctaga agagtaaaag gccaagctat gatagcaact ggtggagtga   2400

taactggcct ggccgccttg aaaaggcaag actctgccag atcacagcag catgtcaacc   2460

tcagcccgtc tcctgctacc caagagaaga agcccatcag gcgccggccc cgggcagatg   2520

ttgtggttgt tcgtggcaaa atccggcttt attccccatc tggttttttt cttattttag   2580

gagtgctcat ctccattata ggaattgcta tggccgttct tggatattgg ccccaaaaag   2640

aacattttat tgatgctgaa acaacactgt caacaaatga aactcaggtc attcggaatg   2700

aaggcggtgt ggtggttcgc ttctttgagc agcatttgca ttctgataag atgaaaatgc   2760

ttggcccatt caccatgggg attggcattt tcattttcat ttgtgctaat gccattcttc   2820

atgaaaaccg tgacaaagag accaaaatca tacacatgag ggatatctat tccacagtca   2880

ttgacattca cacgctaaga atcaaggagc aaaggcaaat gaacggcatg tacactggtt   2940

tgatgggaga aacagaagta aaacagaatg ggagctcctg tgcctcgaga ttggcagcaa   3000

atacgatcgc ctctttctcg ggttttcgga gcagttttcg aatggacagc tccgtggagg   3060

aggatgaact tatgttaaat gaaggtaaga gttctgggca tcttatgccc cctttgctct   3120

ctgacagctc tgtgtctgtc tttggcctct atccacctcc ttccaagaca actgatgata   3180

agaccagcgg ctctaagaaa tgtgaaacca agtcaattgt gtcatcgtcc atcagtgctt   3240

ttacattgcc tgtgatcaaa cttaataact gtgttattga tgagcccagt atagataaca   3300

tcactgaaga tgctgacaac ctcaaaagta ggtcaaggaa tttgtcaatg gattcccttg   3360

tggttccttt gcccaacacc agtgaatcct tccagcccgt cagcacagtg ctaccaagga   3420

ataattccat tggggagtcg ttgtcgagtc agtacaagtc atctatggct ctcggacctg   3480

gggctggaca gctcttgtct cctggggctg ccagaagaca gtttgggtcc aatacatcct   3540

tgcatttgct ctcgtcacac tcaaagtcct tggacttaga ccggggtccc tccactctaa   3600

ctgttcaggc agaacaacgg aaacatccaa gttggcctag gttggatcgg aacaacagca   3660

agggatatat gaaactagag aacaaagaag acccgatgga taggttgctt gtgccccaag   3720

ttgccatcaa aaaggacttt accaataagg agaagcttct tatgatttca agatctcaca   3780

ataatttgag ttttgaacat gatgagtttt tgagtaacaa cctaaagagg ggaacttctg   3840

aaacaaggtt ttaatgttaa aagaatatat cattttacaa gggtatatat tttaaaacga   3900

ttttcactgg tgtttccttc ttaaagtatt ggctgtaagc ctttttaatc aaatggtttg   3960

tagtgtatta gaattggctg cttagttctg taatgaagat ggttgtatgt ttgggttact   4020

tgtgactgca gtactctatg ttaccacaca tgattttatt tttctcttcc tttgaaagca   4080

tgatctcttt tattaatatg aatgcaaaat gcttgcatcc aaattaaagc ttattttctt   4140

tacttttaag ttctttgatt gccctattca taaaatgaaa tgtccagtat ggaaaacata   4200

gggtaccaaa gtgtggacca ggagtacaaa ttcagtccca atactcaata cgtattatag   4260

atgactatga gtgcaaacct taggatgtga ttttctgaat aattgttctt tgtaggattt   4320

ggttacatta tttaaaatga aaaagatcta gttttagtgt gagctcagta atgttaattg   4380

gttaagttca ttgtgaatct tgagttttag ataagtagtt atttttttca atatcacttc   4440

tgtttttagt gatattatat caagaaacaa cgtattcaag agccatggct gacagtgcca   4500

gatatactta gggataaaca tcaaaatgca attatagttg ctataacgtt agatactcgg   4560

aatcaaaatt tatttgcaag ctgacttgat aaactaaatg aaccaataaa atttgtagaa   4620

atgctatcct gaaataatta tatacatgaa gacaatgttg actaatgaat taagatacat   4680

tatatactag ttaatgctaa ctagtctcag tacctgtttt tagccatctg ttactgtcca   4740

atagcacctc attcccacat tctattttcc cccggtattc tttagatcct agtatttgga   4800

aaacaatcgg ctaaccttga catttctttt taccttcata tgccactatc tcggtagttc   4860

aaaaaaattt agttcttgat aaattgcctt gaagtttacc ttgtgctgga gagccttatg   4920

ataactccaa agactttctt acggtataat acatgttgtt taggattgtg tttcttagtc   4980

actgaagata ataaatatta aaatggatgt tttcatcaga aaaaaaaaaa aaaaaaaaaa   5040

aa                                                                  5042


<210>  1866
<211>  491
<212>  PRT
<213>  Homosapiens

<400>  1866

Met Ile Ala Thr Gly Gly Val Ile Thr Gly Leu Ala Ala Leu Lys Arg 
1               5                   10                  15      


Gln Asp Ser Ala Arg Ser Gln Gln His Val Asn Leu Ser Pro Ser Pro 
            20                  25                  30          


Ala Thr Gln Glu Lys Lys Pro Ile Arg Arg Arg Pro Arg Ala Asp Val 
        35                  40                  45              


Val Val Val Arg Gly Lys Ile Arg Leu Tyr Ser Pro Ser Gly Phe Phe 
    50                  55                  60                  


Leu Ile Leu Gly Val Leu Ile Ser Ile Ile Gly Ile Ala Met Ala Val 
65                  70                  75                  80  


Leu Gly Tyr Trp Pro Gln Lys Glu His Phe Ile Asp Ala Glu Thr Thr 
                85                  90                  95      


Leu Ser Thr Asn Glu Thr Gln Val Ile Arg Asn Glu Gly Gly Val Val 
            100                 105                 110         


Val Arg Phe Phe Glu Gln His Leu His Ser Asp Lys Met Lys Met Leu 
        115                 120                 125             


Gly Pro Phe Thr Met Gly Ile Gly Ile Phe Ile Phe Ile Cys Ala Asn 
    130                 135                 140                 


Ala Ile Leu His Glu Asn Arg Asp Lys Glu Thr Lys Ile Ile His Met 
145                 150                 155                 160 


Arg Asp Ile Tyr Ser Thr Val Ile Asp Ile His Thr Leu Arg Ile Lys 
                165                 170                 175     


Glu Gln Arg Gln Met Asn Gly Met Tyr Thr Gly Leu Met Gly Glu Thr 
            180                 185                 190         


Glu Val Lys Gln Asn Gly Ser Ser Cys Ala Ser Arg Leu Ala Ala Asn 
        195                 200                 205             


Thr Ile Ala Ser Phe Ser Gly Phe Arg Ser Ser Phe Arg Met Asp Ser 
    210                 215                 220                 


Ser Val Glu Glu Asp Glu Leu Met Leu Asn Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 


His Leu Met Pro Pro Leu Leu Ser Asp Ser Ser Val Ser Val Phe Gly 
                245                 250                 255     


Leu Tyr Pro Pro Pro Ser Lys Thr Thr Asp Asp Lys Thr Ser Gly Ser 
            260                 265                 270         


Lys Lys Cys Glu Thr Lys Ser Ile Val Ser Ser Ser Ile Ser Ala Phe 
        275                 280                 285             


Thr Leu Pro Val Ile Lys Leu Asn Asn Cys Val Ile Asp Glu Pro Ser 
    290                 295                 300                 


Ile Asp Asn Ile Thr Glu Asp Ala Asp Asn Leu Lys Ser Arg Ser Arg 
305                 310                 315                 320 


Asn Leu Ser Met Asp Ser Leu Val Val Pro Leu Pro Asn Thr Ser Glu 
                325                 330                 335     


Ser Phe Gln Pro Val Ser Thr Val Leu Pro Arg Asn Asn Ser Ile Gly 
            340                 345                 350         


Glu Ser Leu Ser Ser Gln Tyr Lys Ser Ser Met Ala Leu Gly Pro Gly 
        355                 360                 365             


Ala Gly Gln Leu Leu Ser Pro Gly Ala Ala Arg Arg Gln Phe Gly Ser 
    370                 375                 380                 


Asn Thr Ser Leu His Leu Leu Ser Ser His Ser Lys Ser Leu Asp Leu 
385                 390                 395                 400 


Asp Arg Gly Pro Ser Thr Leu Thr Val Gln Ala Glu Gln Arg Lys His 
                405                 410                 415     


Pro Ser Trp Pro Arg Leu Asp Arg Asn Asn Ser Lys Gly Tyr Met Lys 
            420                 425                 430         


Leu Glu Asn Lys Glu Asp Pro Met Asp Arg Leu Leu Val Pro Gln Val 
        435                 440                 445             


Ala Ile Lys Lys Asp Phe Thr Asn Lys Glu Lys Leu Leu Met Ile Ser 
    450                 455                 460                 


Arg Ser His Asn Asn Leu Ser Phe Glu His Asp Glu Phe Leu Ser Asn 
465                 470                 475                 480 


Asn Leu Lys Arg Gly Thr Ser Glu Thr Arg Phe 
                485                 490     


<210>  1867
<211>  2562
<212>  DNA
<213>  Homosapiens

<400>  1867
atggctctaa ccaccccttc agcttcccct cttccctctt tctccatagt tcctggtgct     60

tcagcccaac tcaccttcat ccagctcctc agggatgctg cctttgccct tgacattgcc    120

atctacctag gaggctcttc tacctccact gccttcttct cccagttgcc tttaacccac    180

ttagctcccg cagggaagcc tttccacaca tataatgagt atggtgcttg gaagcgccat    240

tacattgctt gtgtgtccca cttagactgg ctgacaccta gggaggctgc tgctacttat    300

gggacgctga atgaacccaa aacagaagat gaggaactac tggagagaca aagagaaaag    360

tgcctgagga aaagaatttg ggagaaaatt gcactacgta agaaggagtt attcaaagtt    420

cgaccccctt gggtgagtgg aacttgctgc tctagcgtgc taaagcccag atgccaacca    480

cgcctctccc agactgtaag ggagcgagtg ggattacatg aagctttgga gaaacagctt    540

gttttgacat cgttagaaac cttgcccaag cgaagcaata tttctggaag ccattcctac    600

cctttattat caaagaaaaa ttggcatgga gttcataaaa atgatgacag atcttcatat    660

gctctccggc cacacttcat gttaatatca tcccggattc ctgcgtatga gatggtgatg    720

gagagtgtga aggctggtgt tgtttctgtg gtatatgaac acagcgtaac cttggaaagc    780

cttctgtatc ttatagaaaa agctctggat gggcagaagg cacagagcat cggaatattt    840

agcgatggag acagcagaga aatcaattta ctccaaggct ataaaattgg tgttaaaaat    900

ttactgaggc ctgaagtgag agatttctgg gagaaattag gaagctatgt ggccactgaa    960

gaagaagggg gtcacgtgga cttcttcgtg ccccttggag catcagaggc aggaattgaa   1020

gttctttccc agctgtctca actaactggc acgttcttta cggcccccac tgggattgca   1080

actggctctt accagcacat tcttagtgat tggctgggat cccaatgggg aaaggccccc   1140

tcttccatct acttctgcga atcgaagcta cagacgtggt ccagcttcac agacttccta   1200

gaagaaacct tgaaaacagt aaggaagcag ctgtatcctt tcttcaagga actgcagaag   1260

agcatcagtg gcaggatgat agggcagttt atgtttgaca ccatgggtat gaccaacatt   1320

ctaaacaacc aagatactgc gcaagctctg gcagatggat tgatggagtt gtcaaaagaa   1380

gattctgaca aacctctgga atttttgtcg tattttctgc tgaagaaatg tggcaaaaag   1440

atcaaagatg ttgaaggaaa tgttattcca acaaaatgtg acccaaagac aacattcagt   1500

ttattcatga aggagagaat actccagaag gactcagcag aaaagcgagc tagagttgtc   1560

agagaactct tacagagtga gagaaaatac gtgcagatac tggaaattgt gagagatgtt   1620

tatgtcgcac cactgaaagc agcattgtca tcaaacagag cgattctgag tgctgccaat   1680

atccagatca ttttctgtga cattctacag attttaagtc tcaacaggca gtttctagat   1740

aacctgagag acagactgca ggaatggggc ccagctcact gtgtgggaga aatagtcacg   1800

aagtttggaa gccagttaaa cacatatacc aatttcttca acaattaccc tgtcattctg   1860

aaaactattg agaagtgcag agaaatgata ccagcattcc gaactttcct gaagaggcat   1920

gataagacca ttgttaccaa aatgctgagc ctgccagagc tgctgctgta cccatcccga   1980

agatttgaag aataccttaa tcttctctac gctgtcaggc ttcatacccc tgcagagcat   2040

gttgaccgtg gggacttgac cactgcaatt gaccaaatca aaaaatataa aggttatata   2100

gatcagatga agcaaaacat cactatgaag gatcatctgt cagatataca gagaatcatc   2160

tggggatgcc ctactctatc agaagtaaac agatatctga ttagggtaca agatgtagcc   2220

caacttcatt gctgtgatga agaaataagt ttctctttaa ggctctatga acacatccat   2280

gatctcagcc ttttcctctt caatgatgcc ctgctcgttt ctagtcgggg cacatctcac   2340

actccatttg agaggacttc aaaaacaacc taccagttca ttgcatcagt ggcccttcat   2400

cggttactca tagaaaatat tccagattcc aagtatgtca agaatgcatt tattcttcag   2460

ggtccaaaat ataaatggat ttgtgctaca gaaatagagg atgataagtt cctatggctg   2520

tcagtacttc gaaatgcaat caaaagcagt atggagaagt ga                      2562


<210>  1868
<211>  853
<212>  PRT
<213>  Homosapiens

<400>  1868

Met Ala Leu Thr Thr Pro Ser Ala Ser Pro Leu Pro Ser Phe Ser Ile 
1               5                   10                  15      


Val Pro Gly Ala Ser Ala Gln Leu Thr Phe Ile Gln Leu Leu Arg Asp 
            20                  25                  30          


Ala Ala Phe Ala Leu Asp Ile Ala Ile Tyr Leu Gly Gly Ser Ser Thr 
        35                  40                  45              


Ser Thr Ala Phe Phe Ser Gln Leu Pro Leu Thr His Leu Ala Pro Ala 
    50                  55                  60                  


Gly Lys Pro Phe His Thr Tyr Asn Glu Tyr Gly Ala Trp Lys Arg His 
65                  70                  75                  80  


Tyr Ile Ala Cys Val Ser His Leu Asp Trp Leu Thr Pro Arg Glu Ala 
                85                  90                  95      


Ala Ala Thr Tyr Gly Thr Leu Asn Glu Pro Lys Thr Glu Asp Glu Glu 
            100                 105                 110         


Leu Leu Glu Arg Gln Arg Glu Lys Cys Leu Arg Lys Arg Ile Trp Glu 
        115                 120                 125             


Lys Ile Ala Leu Arg Lys Lys Glu Leu Phe Lys Val Arg Pro Pro Trp 
    130                 135                 140                 


Val Ser Gly Thr Cys Cys Ser Ser Val Leu Lys Pro Arg Cys Gln Pro 
145                 150                 155                 160 


Arg Leu Ser Gln Thr Val Arg Glu Arg Val Gly Leu His Glu Ala Leu 
                165                 170                 175     


Glu Lys Gln Leu Val Leu Thr Ser Leu Glu Thr Leu Pro Lys Arg Ser 
            180                 185                 190         


Asn Ile Ser Gly Ser His Ser Tyr Pro Leu Leu Ser Lys Lys Asn Trp 
        195                 200                 205             


His Gly Val His Lys Asn Asp Asp Arg Ser Ser Tyr Ala Leu Arg Pro 
    210                 215                 220                 


His Phe Met Leu Ile Ser Ser Arg Ile Pro Ala Tyr Glu Met Val Met 
225                 230                 235                 240 


Glu Ser Val Lys Ala Gly Val Val Ser Val Val Tyr Glu His Ser Val 
                245                 250                 255     


Thr Leu Glu Ser Leu Leu Tyr Leu Ile Glu Lys Ala Leu Asp Gly Gln 
            260                 265                 270         


Lys Ala Gln Ser Ile Gly Ile Phe Ser Asp Gly Asp Ser Arg Glu Ile 
        275                 280                 285             


Asn Leu Leu Gln Gly Tyr Lys Ile Gly Val Lys Asn Leu Leu Arg Pro 
    290                 295                 300                 


Glu Val Arg Asp Phe Trp Glu Lys Leu Gly Ser Tyr Val Ala Thr Glu 
305                 310                 315                 320 


Glu Glu Gly Gly His Val Asp Phe Phe Val Pro Leu Gly Ala Ser Glu 
                325                 330                 335     


Ala Gly Ile Glu Val Leu Ser Gln Leu Ser Gln Leu Thr Gly Thr Phe 
            340                 345                 350         


Phe Thr Ala Pro Thr Gly Ile Ala Thr Gly Ser Tyr Gln His Ile Leu 
        355                 360                 365             


Ser Asp Trp Leu Gly Ser Gln Trp Gly Lys Ala Pro Ser Ser Ile Tyr 
    370                 375                 380                 


Phe Cys Glu Ser Lys Leu Gln Thr Trp Ser Ser Phe Thr Asp Phe Leu 
385                 390                 395                 400 


Glu Glu Thr Leu Lys Thr Val Arg Lys Gln Leu Tyr Pro Phe Phe Lys 
                405                 410                 415     


Glu Leu Gln Lys Ser Ile Ser Gly Arg Met Ile Gly Gln Phe Met Phe 
            420                 425                 430         


Asp Thr Met Gly Met Thr Asn Ile Leu Asn Asn Gln Asp Thr Ala Gln 
        435                 440                 445             


Ala Leu Ala Asp Gly Leu Met Glu Leu Ser Lys Glu Asp Ser Asp Lys 
    450                 455                 460                 


Pro Leu Glu Phe Leu Ser Tyr Phe Leu Leu Lys Lys Cys Gly Lys Lys 
465                 470                 475                 480 


Ile Lys Asp Val Glu Gly Asn Val Ile Pro Thr Lys Cys Asp Pro Lys 
                485                 490                 495     


Thr Thr Phe Ser Leu Phe Met Lys Glu Arg Ile Leu Gln Lys Asp Ser 
            500                 505                 510         


Ala Glu Lys Arg Ala Arg Val Val Arg Glu Leu Leu Gln Ser Glu Arg 
        515                 520                 525             


Lys Tyr Val Gln Ile Leu Glu Ile Val Arg Asp Val Tyr Val Ala Pro 
    530                 535                 540                 


Leu Lys Ala Ala Leu Ser Ser Asn Arg Ala Ile Leu Ser Ala Ala Asn 
545                 550                 555                 560 


Ile Gln Ile Ile Phe Cys Asp Ile Leu Gln Ile Leu Ser Leu Asn Arg 
                565                 570                 575     


Gln Phe Leu Asp Asn Leu Arg Asp Arg Leu Gln Glu Trp Gly Pro Ala 
            580                 585                 590         


His Cys Val Gly Glu Ile Val Thr Lys Phe Gly Ser Gln Leu Asn Thr 
        595                 600                 605             


Tyr Thr Asn Phe Phe Asn Asn Tyr Pro Val Ile Leu Lys Thr Ile Glu 
    610                 615                 620                 


Lys Cys Arg Glu Met Ile Pro Ala Phe Arg Thr Phe Leu Lys Arg His 
625                 630                 635                 640 


Asp Lys Thr Ile Val Thr Lys Met Leu Ser Leu Pro Glu Leu Leu Leu 
                645                 650                 655     


Tyr Pro Ser Arg Arg Phe Glu Glu Tyr Leu Asn Leu Leu Tyr Ala Val 
            660                 665                 670         


Arg Leu His Thr Pro Ala Glu His Val Asp Arg Gly Asp Leu Thr Thr 
        675                 680                 685             


Ala Ile Asp Gln Ile Lys Lys Tyr Lys Gly Tyr Ile Asp Gln Met Lys 
    690                 695                 700                 


Gln Asn Ile Thr Met Lys Asp His Leu Ser Asp Ile Gln Arg Ile Ile 
705                 710                 715                 720 


Trp Gly Cys Pro Thr Leu Ser Glu Val Asn Arg Tyr Leu Ile Arg Val 
                725                 730                 735     


Gln Asp Val Ala Gln Leu His Cys Cys Asp Glu Glu Ile Ser Phe Ser 
            740                 745                 750         


Leu Arg Leu Tyr Glu His Ile His Asp Leu Ser Leu Phe Leu Phe Asn 
        755                 760                 765             


Asp Ala Leu Leu Val Ser Ser Arg Gly Thr Ser His Thr Pro Phe Glu 
    770                 775                 780                 


Arg Thr Ser Lys Thr Thr Tyr Gln Phe Ile Ala Ser Val Ala Leu His 
785                 790                 795                 800 


Arg Leu Leu Ile Glu Asn Ile Pro Asp Ser Lys Tyr Val Lys Asn Ala 
                805                 810                 815     


Phe Ile Leu Gln Gly Pro Lys Tyr Lys Trp Ile Cys Ala Thr Glu Ile 
            820                 825                 830         


Glu Asp Asp Lys Phe Leu Trp Leu Ser Val Leu Arg Asn Ala Ile Lys 
        835                 840                 845             


Ser Ser Met Glu Lys 
    850             


<210>  1869
<211>  3565
<212>  DNA
<213>  Homosapiens

<400>  1869
ccgccgctgt cactgttggt gcgggcgcgt cggggccggg ccggggcact gtaaatggcg     60

gcggagggag gcggagcggc ggccacgctc agcccagatc ccccgaaact ttaggttcga    120

agccccacaa ctttccggga agcgctgccg ctccggaggc gtggacggaa ggggaagccg    180

aggcgggaag tctgggggaa tcggcaggga gccggggaga ctcgaacccg cggcgggggc    240

ggagtccgcc agtgcctcgc gcctccgcgg cccccgcctc tttctctgca ccctccccgc    300

ggccggagcc ggagccggag ccggagccgt agtcgcagcc gcagccgcag ccgcgcgccg    360

ggcctcgcag gcagcggcgc ggcgagcgca gccgggcccc ctcctcgcga cctccgggcc    420

ctgttgctcg ggcgcacctg gcgcgtgtga ggccggggcc ggcgttttcg ggaagctagc    480

aggaggccgg gccacgcgca gcccctgccg gcccaggttc ctggggccgg gccccgagta    540

gtgcatgcgg ggcggggcgg ccgtgagccg gaggcgaaga tggaaggctt aacgctgagc    600

gatgcggagc agaaatacta ttcagatctc ttctcctact gcgacattga gagcaccaag    660

aaggtggtgg tcaacgggcg ggtgctggag ctgttccggg ccgcgcagct gccgaacgac    720

gtggtcctac agatcatgga gctttgtggt gcaacaagac ttggttattt tggaagaagt    780

cagttctaca ttgctttgaa acttgtagct gttgcccagt ctggtttccc tttaagagtg    840

gaaagtataa atacagtaaa ggaccttcct ctgccaagat ttgttgcttc aaagaatgaa    900

caggaatctc gccatgcagc ctcatattct tcagattctg aaaatcaagg gtcgtattct    960

ggtgtaattc ccccaccacc tggcaggggg caagtgaaaa agggatccgt aagccatgat   1020

acggttcagc ctcgtacatc tgcagatgca caggaacctg catccccagt agtttcacca   1080

cagcaatccc caccaacttc tccacacaca tggaggaagc acagccgtca tcccagcggt   1140

gggaatagtg agaggcctct cgcgggacct gggccatttt ggtctccctt tggtgaagca   1200

caatcaggtt cttctgctgg tgatgcagtg tggtcagggc attccccacc tccacctcaa   1260

gaaaactggg tcagttttgc agatactcca ccaaccagta ctcttttaac catgcatcct   1320

gcttctgtcc aggaccagac aacagtacga actgtagcat cagctacaac tgccattgaa   1380

attcgtaggc aatccagtag ttatgatgat ccctggaaaa taacagatga acaaagacag   1440

tattatgtaa atcagtttaa aaccattcag cctgatctaa acggatttat tccaggatct   1500

gcagctaaag agttttttac aaaatcaaaa cttcctattc ttgaactttc tcatatttgg   1560

gaactctcag actttgataa agatggtgca ttgacactgg atgagttttg tgctgctttt   1620

catctggtgg ttgctaggaa gaatggctat gatttaccag aaaaacttcc tgaaagctta   1680

atgcccaaac tgattgattt ggaagattca gcagatgttg gggatcagcc aggtgaggta   1740

ggttattcag gctctcctgc tgaagctcct ccaagcaagt caccatcgat gccatcacta   1800

aaccagacat ggcctgagct gaatcagagc agtgagcagt gggagacatt tagtgaacgc   1860

tcttcaagct cacaaactct gacccaattt gattctaaca ttgcaccagc tgatcctgat   1920

actgctattg ttcatccagt tcccattcgt atgactccaa gcaaaatcca catgcaggaa   1980

atggaactta aaagaactgg cagcgatcat acaaatccca ctagcccatt acttgtgaaa   2040

ccatctgacc ttttagaaga aaataagata aattcatcgg tgaaattcgc ttctggtaat   2100

actgtagatg gttacagtag ttcagactct tttacttctg acccagaaca gatcgggagc   2160

aatgtaactc gtcaaaggtc tcattcagga acgtcgcctg ataacactgc accaccacct   2220

ccccctccaa ggccacagcc ctctcattct agatcatcat ctttagatat gaatcggacc   2280

tttacagtca ccacaggaca acaacaggct ggagttgttg cccatcctcc tgcagtgcct   2340

ccaagaccac agccctcaca ggctcctggt cctgctgtgc atcgcccagt ggatgccgat   2400

ggcctcataa ctcacactag tacctcacct cagcagatac cagagcaacc aaattttgca   2460

gatttcagtc agtttgaagt atttgctgca tcaaatgtaa acgacgaaca agatgatgaa   2520

gccgagaaac atccagaagt cctgccggct gaaaaagctt ctgatcctgc aagttctctt   2580

cgagttgcca aaacagatag taaaactgaa gaaaagacag ctgctagtgc tcctgccaat   2640

gtgagcaaag gcacaacacc acttgctcca ccacctaaac ctgttcgaag aagattaaaa   2700

tcagaagatg aattaaggcc agaagttgat gaacatacac aaaagacggg tgtcttagct   2760

gctgttcttg catcacaacc ttctattccc agatctgttg ggaaagataa gaaagctatt   2820

caggcatcaa ttagacgtaa taaggaaacc aacaccgttt tggccagatt gaatagcgaa   2880

ttgcagcaac aattaaagga tgttcttgag gagagaattt ccctggaagt tcaactggaa   2940

caacttcgac cattctctca cctataagcc aattgccgtt aactgtgaac atacttgttt   3000

ttaagtggtt ttgggttcaa agccaatttg gagacctaga cattcagctc actgcttaac   3060

tcaacattaa attttatgat tctgttttgc cctatatgtt caccgttgta tttaagtatc   3120

ttttattttt taatttcgac aataaaaagg tcaggatggc gttttctgga gggtagattg   3180

tgtttgttgg cacacccacc ttttctgttc cctagcatct gggatatgca atgcttctat   3240

ggctaatacc acacaccaat ttaatttata gaatgggctc ctcatttaca tctcagtcac   3300

agactcagaa ataaattgtc agtttgtcct tttatgttta atattttaca taaagcatct   3360

attctataaa aatctttaga aagagtttcc catttaattt tgattttaaa gaattatatt   3420

ggataaggtg gttttcacca taagctaatt tactctctgc agccgtctac attcttcaca   3480

aatcatgtgg tacattgaag cctcttttac atgtcaactt gtgacaaata caaacatgtg   3540

agattttaaa aaaaaaaaaa aaaaa                                         3565


<210>  1870
<211>  743
<212>  PRT
<213>  Homosapiens

<400>  1870

Met Glu Leu Cys Gly Ala Thr Arg Leu Gly Tyr Phe Gly Arg Ser Gln 
1               5                   10                  15      


Phe Tyr Ile Ala Leu Lys Leu Val Ala Val Ala Gln Ser Gly Phe Pro 
            20                  25                  30          


Leu Arg Val Glu Ser Ile Asn Thr Val Lys Asp Leu Pro Leu Pro Arg 
        35                  40                  45              


Phe Val Ala Ser Lys Asn Glu Gln Glu Ser Arg His Ala Ala Ser Tyr 
    50                  55                  60                  


Ser Ser Asp Ser Glu Asn Gln Gly Ser Tyr Ser Gly Val Ile Pro Pro 
65                  70                  75                  80  


Pro Pro Gly Arg Gly Gln Val Lys Lys Gly Ser Val Ser His Asp Thr 
                85                  90                  95      


Val Gln Pro Arg Thr Ser Ala Asp Ala Gln Glu Pro Ala Ser Pro Val 
            100                 105                 110         


Val Ser Pro Gln Gln Ser Pro Pro Thr Ser Pro His Thr Trp Arg Lys 
        115                 120                 125             


His Ser Arg His Pro Ser Gly Gly Asn Ser Glu Arg Pro Leu Ala Gly 
    130                 135                 140                 


Pro Gly Pro Phe Trp Ser Pro Phe Gly Glu Ala Gln Ser Gly Ser Ser 
145                 150                 155                 160 


Ala Gly Asp Ala Val Trp Ser Gly His Ser Pro Pro Pro Pro Gln Glu 
                165                 170                 175     


Asn Trp Val Ser Phe Ala Asp Thr Pro Pro Thr Ser Thr Leu Leu Thr 
            180                 185                 190         


Met His Pro Ala Ser Val Gln Asp Gln Thr Thr Val Arg Thr Val Ala 
        195                 200                 205             


Ser Ala Thr Thr Ala Ile Glu Ile Arg Arg Gln Ser Ser Ser Tyr Asp 
    210                 215                 220                 


Asp Pro Trp Lys Ile Thr Asp Glu Gln Arg Gln Tyr Tyr Val Asn Gln 
225                 230                 235                 240 


Phe Lys Thr Ile Gln Pro Asp Leu Asn Gly Phe Ile Pro Gly Ser Ala 
                245                 250                 255     


Ala Lys Glu Phe Phe Thr Lys Ser Lys Leu Pro Ile Leu Glu Leu Ser 
            260                 265                 270         


His Ile Trp Glu Leu Ser Asp Phe Asp Lys Asp Gly Ala Leu Thr Leu 
        275                 280                 285             


Asp Glu Phe Cys Ala Ala Phe His Leu Val Val Ala Arg Lys Asn Gly 
    290                 295                 300                 


Tyr Asp Leu Pro Glu Lys Leu Pro Glu Ser Leu Met Pro Lys Leu Ile 
305                 310                 315                 320 


Asp Leu Glu Asp Ser Ala Asp Val Gly Asp Gln Pro Gly Glu Val Gly 
                325                 330                 335     


Tyr Ser Gly Ser Pro Ala Glu Ala Pro Pro Ser Lys Ser Pro Ser Met 
            340                 345                 350         


Pro Ser Leu Asn Gln Thr Trp Pro Glu Leu Asn Gln Ser Ser Glu Gln 
        355                 360                 365             


Trp Glu Thr Phe Ser Glu Arg Ser Ser Ser Ser Gln Thr Leu Thr Gln 
    370                 375                 380                 


Phe Asp Ser Asn Ile Ala Pro Ala Asp Pro Asp Thr Ala Ile Val His 
385                 390                 395                 400 


Pro Val Pro Ile Arg Met Thr Pro Ser Lys Ile His Met Gln Glu Met 
                405                 410                 415     


Glu Leu Lys Arg Thr Gly Ser Asp His Thr Asn Pro Thr Ser Pro Leu 
            420                 425                 430         


Leu Val Lys Pro Ser Asp Leu Leu Glu Glu Asn Lys Ile Asn Ser Ser 
        435                 440                 445             


Val Lys Phe Ala Ser Gly Asn Thr Val Asp Gly Tyr Ser Ser Ser Asp 
    450                 455                 460                 


Ser Phe Thr Ser Asp Pro Glu Gln Ile Gly Ser Asn Val Thr Arg Gln 
465                 470                 475                 480 


Arg Ser His Ser Gly Thr Ser Pro Asp Asn Thr Ala Pro Pro Pro Pro 
                485                 490                 495     


Pro Pro Arg Pro Gln Pro Ser His Ser Arg Ser Ser Ser Leu Asp Met 
            500                 505                 510         


Asn Arg Thr Phe Thr Val Thr Thr Gly Gln Gln Gln Ala Gly Val Val 
        515                 520                 525             


Ala His Pro Pro Ala Val Pro Pro Arg Pro Gln Pro Ser Gln Ala Pro 
    530                 535                 540                 


Gly Pro Ala Val His Arg Pro Val Asp Ala Asp Gly Leu Ile Thr His 
545                 550                 555                 560 


Thr Ser Thr Ser Pro Gln Gln Ile Pro Glu Gln Pro Asn Phe Ala Asp 
                565                 570                 575     


Phe Ser Gln Phe Glu Val Phe Ala Ala Ser Asn Val Asn Asp Glu Gln 
            580                 585                 590         


Asp Asp Glu Ala Glu Lys His Pro Glu Val Leu Pro Ala Glu Lys Ala 
        595                 600                 605             


Ser Asp Pro Ala Ser Ser Leu Arg Val Ala Lys Thr Asp Ser Lys Thr 
    610                 615                 620                 


Glu Glu Lys Thr Ala Ala Ser Ala Pro Ala Asn Val Ser Lys Gly Thr 
625                 630                 635                 640 


Thr Pro Leu Ala Pro Pro Pro Lys Pro Val Arg Arg Arg Leu Lys Ser 
                645                 650                 655     


Glu Asp Glu Leu Arg Pro Glu Val Asp Glu His Thr Gln Lys Thr Gly 
            660                 665                 670         


Val Leu Ala Ala Val Leu Ala Ser Gln Pro Ser Ile Pro Arg Ser Val 
        675                 680                 685             


Gly Lys Asp Lys Lys Ala Ile Gln Ala Ser Ile Arg Arg Asn Lys Glu 
    690                 695                 700                 


Thr Asn Thr Val Leu Ala Arg Leu Asn Ser Glu Leu Gln Gln Gln Leu 
705                 710                 715                 720 


Lys Asp Val Leu Glu Glu Arg Ile Ser Leu Glu Val Gln Leu Glu Gln 
                725                 730                 735     


Leu Arg Pro Phe Ser His Leu 
            740             


<210>  1871
<211>  966
<212>  DNA
<213>  Homosapiens

<400>  1871
atgcactact cggggcccgg ccccaggaac ctgggccggc aggggctgcg cgtggcccgg     60

cctcctgcta gcttcccgaa aacgccggcc ccggcctcac acgcgccagg cttgtccctg    120

ggagtgtggg cggccccttt cttgagcgca gaaacactta cttttccccc taccctgctc    180

ctcctcctcc acagccgtct ttctctttgc ctcagccact tccttccttg gcctcaccct    240

ccccagtgca ctgaagaagg taaccgggtc cagacccacg cggcgccagt tctccggcgg    300

gaaggaaaac cgcgcagaga ggcagcaatg aatgtggatc acgaggttaa cctcttagtg    360

gaggaaattc atcgtttggg ttcaaaaaat gctgatggaa agttaagcgt gaaatttggg    420

gtcctcttcc gtgatgataa atgtgccaac ctctttgaag cattggtagg aactcttaaa    480

gctgcaaaac gaaggaagat tgtaacatat ccaggagagc tgcttctgca aggtgttcat    540

gatgatgttg acattatatt actgcaagat taatgtggtt tacatatctt tatgtactgc    600

cattttttgt ttctggtaaa ctggaatata aagtgaaaga acaaacattt gaacatactt    660

aatgtatttt tatagaactt tgtaaacgaa aggagattca tgttttagaa gtctgtcctt    720

ttttatatct tgaaagaaaa tctatgtatg atgctataaa ataaatccta ttatttttct    780

caggaatctg gttaggaatt gcaggcaatg agattttttg cggggcaggg atgggaatgt    840

ttgttcataa ataattagac attttctata gatatttgac attctgcgaa agcaacaagc    900

aaactgaaga ccaactccta tgagaaatat tatgatgttt atgtaataaa gacatgtaac    960

tgtctt                                                               966


<210>  1872
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  1872

Met His Tyr Ser Gly Pro Gly Pro Arg Asn Leu Gly Arg Gln Gly Leu 
1               5                   10                  15      


Arg Val Ala Arg Pro Pro Ala Ser Phe Pro Lys Thr Pro Ala Pro Ala 
            20                  25                  30          


Ser His Ala Pro Gly Leu Ser Leu Gly Val Trp Ala Ala Pro Phe Leu 
        35                  40                  45              


Ser Ala Glu Thr Leu Thr Phe Pro Pro Thr Leu Leu Leu Leu Leu His 
    50                  55                  60                  


Ser Arg Leu Ser Leu Cys Leu Ser His Phe Leu Pro Trp Pro His Pro 
65                  70                  75                  80  


Pro Gln Cys Thr Glu Glu Gly Asn Arg Val Gln Thr His Ala Ala Pro 
                85                  90                  95      


Val Leu Arg Arg Glu Gly Lys Pro Arg Arg Glu Ala Ala Met Asn Val 
            100                 105                 110         


Asp His Glu Val Asn Leu Leu Val Glu Glu Ile His Arg Leu Gly Ser 
        115                 120                 125             


Lys Asn Ala Asp Gly Lys Leu Ser Val Lys Phe Gly Val Leu Phe Arg 
    130                 135                 140                 


Asp Asp Lys Cys Ala Asn Leu Phe Glu Ala Leu Val Gly Thr Leu Lys 
145                 150                 155                 160 


Ala Ala Lys Arg Arg Lys Ile Val Thr Tyr Pro Gly Glu Leu Leu Leu 
                165                 170                 175     


Gln Gly Val His Asp Asp Val Asp Ile Ile Leu Leu Gln Asp 
            180                 185                 190 


<210>  1873
<211>  5621
<212>  DNA
<213>  Homosapiens

<400>  1873
gccttttccc tccggctcgg gagcgtctcg cttgcgcccc gggcccgcgg cgcccgcgcg     60

gctgcgagcc tcgggtggcc gcgtgccggc tccaggaagc cggagagggc gcggcggcca    120

ggatggcgcg gcacgggccg tgcggctaga cgggagccga gggaaccgcc ggctcgcgcc    180

ctccgttctt tcccggagcc ggcttcacgc agggccggga acggccgtgc ctctgggatc    240

cgccttcgct gacgccgggc acctacctgg acgcgagcga gcgagatgcc caaccccaaa    300

aacagcaaag gcggccgcaa aaacaagcgc gccaacagca gcggcgacga gcaggaaaat    360

ggagccgggg ccctggcagc ggcgggcgcg gcgggagcgg cggccggggg ggccctggcg    420

gcggcggccg gttgcggggc ggcggcggcg ggcgcgccgg gcgccggagg cgcggcgggc    480

gccggaggcg cggggactgg cgccgcgaac gctgcggccg ccgcgggggc tgcggccgcg    540

ggcgatgcca aaaacgaagc cccatgtgcc actcccctga tctgcagctt cggtaggccg    600

gtggacctgg agaaggacga ctaccagaag gtggtgtgca acaacgagca ctgcccctgc    660

agcacctgga tgcacctgca gtgcttctac gagtgggaga gcagcatcct cgtccagttc    720

aactgcatcg gccgcgcgcg cagctggaac gagaagcaat gccgccagaa catgtggaca    780

aagaagggct acgacctggc cttccgcttc tgctcttgcc gctgtggcca gggccacttg    840

aagaaggaca cagactggta tcaggtgaag cggatgcagg acgagaaaaa gaagaagtct    900

ggctccgaga agaacacagg gaggcctcct ggtgaggcgg cggaggaggc aaaaaagtgc    960

aggcccccaa ataagcccca gaaaggccca agccacgacc tcccccgccg gcattccatg   1020

gaccggcaga actcccagga gaaggcagtg ggtgccgcag cctacggtgc ccgttccccc   1080

ggtggctccc cgggccagtc cccacccacg ggctactcca tcctctctcc tgcccacttc   1140

agcggccccc gctcctccag atacctcggg gagttcttaa agaacgccat ccatctggag   1200

cctcacaaga aggccatggc tgggggccat gtgttcagaa atgcccactt tgattacagc   1260

cctgcggggt tggcagttca caggggggga cacttcgaca cccccgtgca gttccttcgg   1320

cggctggacc tctccgaact cctcactcac atccccaggc ataagctgaa cactttccac   1380

gtgcgcatgg aagacgatgc ccaagtgggc cagggggaag acttgcggaa gttcattctg   1440

gccgcgctca gtgccagcca cagaaacgtg gtaaactgtg ccctgtgcca ccgggcgctc   1500

ccggtgttcg aacagttccc actggtggat ggaactttgt tcctaagccc gtcgagacat   1560

gatgagatcg aatatgatgt tccttgtcac cttcaaggga gactcatgca tctgtatgcc   1620

gtgtgcgtgg actgcctgga aggggttcac aagatcatct gcatcaagtg taagtcacgg   1680

tgggatggca gctggcacca gctgggcact atgtacacct acgacatcct ggctgcctct   1740

ccatgttgtc aggcccgcct gaactgtaag cactgtggga agccggtgat cgacgtgagg   1800

atcgggatgc agtacttctc cgaatatagc aacgtccagc agtgtccaca ctgtgggaac   1860

ctggactacc acttcgtgaa gccattttcc tccttcaaag ttctcgaagc ttattgatga   1920

aagctttgct ttagtaatag ctattttatt gatattatta ctttattaca tatcttttat   1980

agggaaacat tctgtgacat taatttcctt tctaatttaa aggagagtta ctttgttgta   2040

tgtgtgccac taaaataggg gctgcccttg ccctgtcttg attcccgagt gttaatctgt   2100

ggttttgacc agagcccaga tgggtaatcc tgtgcatttg ggttggggtt cactcttacc   2160

aagaatcttt gatgcagctt taagatggtg gggaggatgg ggtgaattta ggaaaggaat   2220

ttgtggttat aaactaagag cttgatagga gttggaagga aactcttact aaaatgttaa   2280

ctttctaaaa accttctttt agatcttcct tgggcctttg gaaaaatatg tgacaagtga   2340

atgtaagtct gtgcctggag agctaatagt gcattagtct atctcagcct agtgttctgc   2400

agcacacatg ggcaggcagt ttactcacac tgacaggtga cctgaaagtg gcacaagtgc   2460

tgtttctatc actattgtaa tttgccagtt catttttcat gctgaaagta atatccaaat   2520

tgtaagacat atgaaagata ttagtgttgc aaatatgttt aggtaaactg acctataaca   2580

gaatatgtga aatgaatttg gaaataatgc aagaaggcag aactcaatca tttaaattgt   2640

gtctttgaag ttggtaatat agcttttaag gagaacccat gaataacctg atttgggcag   2700

tgatgattta ttacaggttg cactgttgaa gtgtcatttg gtgtcaggtt cttctcacag   2760

gtaaatcttt cagccacaga atctaactgg tgagcttcag aaccaataat tgccacattt   2820

attgtcctca aaattgctta tggccatgta taaccaatta attctgagtt tccaaaatca   2880

aagatttgac cttaagaggg aagggaaaaa agtgtgaaag gatgatgaag aaaataattt   2940

tactatttct tttaaaagta tgttttggaa aatcaatgat tttaatgcat agcagtatgt   3000

ttgaaaaata gaccattcta aaaagcccat gataccttac tgttgatgaa aaaggatgat   3060

catatatata gaacttgatt agtcagagca ttgggcattc caaaatacag cctttggttc   3120

agtagatttt aatgctttaa atagactgac gtcgcatacc cttatagaat tggaatatga   3180

tttctcaaaa attaatttga taatttcatg tatgatgtgc atatatgcta aaagaatgca   3240

gaaaatcatt ttatgaatag ccaaatttgg ggttgatgtg aacattttat gttactcatt   3300

tggtttatac tttttttttt ttttttttaa ctgtgtggtt tttcttttca gaagtattta   3360

ggcaatattg cacgtgagtt tcagttcttt ttttcttttt tttgagatgg agtctcactc   3420

ttgtcaccca ggctggagtg cagtagtgcg atctcagctc actgcaacct ctgcctcctg   3480

gattcaagcg attctcctgt cccagcctcc caggtagctg ggactatagg cacgtgccac   3540

cacacccggc taattttttg tatttttagt agagacagcg tttcaccatg ttagctagga   3600

tggtctagat ctcctgacct tgtgatctgc ctgcctcggc ctcccaaagt gctgggatta   3660

caggcgtgag tcactgtgcc tggccaagtt tcagttctat atgaagtatt tgatgttttg   3720

tttgaaacaa tacagcatta aagaaccaat gttattcact aatatcattc atctttcagt   3780

ttggatgatt tggtttgctg catctaggtt ggtgtttgat catctgaaaa aacatttcag   3840

tgggaagaaa tgcataaaat gcctataaga agtagaaagt cattgaactg acagtgtttg   3900

atgcaactaa aagaggattg taagacatag ctttctgcaa acttgtcttt aatgcacaaa   3960

gctgtagtgg tgaattaact atctccttat tgattctctc ctgtacccag atgcaaaaag   4020

tgctaagttt ctcttgtcct cgtaatacca tttggatttt atttctgaat ttaaatagta   4080

aaatatttat gatgctgatc tttaacccac ctaaaatttt atagtgaaac ctgctttata   4140

ttgttgttct gaagcttaca attgacctat acattgcatt cagcaagctc ctgaatttag   4200

aactgccgtc agtgtagtgt atgctgtgtt ccatgttgcc tttttagatg gctttctacc   4260

ccctgaacaa taaataggat gaggttttac tgtaattggg taaagtttac tcttggacat   4320

tatttcgatg ctaaagtaag gattctgtgg atgttactta aagagaaaag cataagagca   4380

tgaagcatat ctgggaatat cttttgcctt taagacgatt cattcttgtc tagagggaaa   4440

atctggctga tttgggaata aaatataatc gaatattcaa caccatgaag ataaatctta   4500

ttttggaaat ctactgacct taatacccca agcttgccct gaatactttg attggaattg   4560

gaatatatca aaaaaggtta gtatttttgt tgtagttagg atactaaaag gatattagtt   4620

acccaagaga tccaatttgt ttttctgatg aatagtgttc agtaaaatga agcagtctta   4680

agagtgacta ataatttcaa agtgattttt cgtctattct taatattttt taattattta   4740

tttttaagag ttttatacct tgagcagata caatgatctg ctttagtgag aggacaattt   4800

ctgattgatt gttttctctt caggccatct cacctcttca ttctcttgtt acatttgaag   4860

cagttgatat aatgggttta tactttaaaa gatagacatg gtgccatgaa gttggggagt   4920

tgggtgaatt atcccattct agttacagag gagctttcct taaatgccct ttaacttcta   4980

ggttttgttc aagaagttca ttttctgagt aaaaggtatt ttcatatatg ttgggggaaa   5040

attaactcat ctaaaaagaa tcttattagg tatttgaact ctaaaactaa cagataagac   5100

agatatgtac cttattagag caccagaact aatttgctaa gtcttttgtt tagtcctgca   5160

agactgatgc ttaatacaca gtctgttctc ctgtgtctag gtcaggaact ccagtttgct   5220

tttctgtttt gtgtcctggt agcagctgtt gagtaacttt cattggaggt tgggaaggaa   5280

gtgaggagaa agtgttcttg tttagtgttt tatttcctat aataggatgc tgcctaaccc   5340

agttcatctc tatgtcctgt tcactgaata ttccgggtaa ttgaaagaaa atataatgga   5400

tgggctccat taaaaccagc tcaaaaataa attcttgtca gtaaagattt cttgtcaaga   5460

tgtcttggat tgcacttttg ttgaggaaag acagtgtaaa tagttaaaga atgttgataa   5520

aattgaaaca tttggttgtg gaattgtgtg tggttttaga gggtttctgt ttgtgaaatg   5580

tatgtattaa aaataataaa attccagaaa ctaacattgt a                       5621


<210>  1874
<211>  543
<212>  PRT
<213>  Homosapiens

<400>  1874

Met Pro Asn Pro Lys Asn Ser Lys Gly Gly Arg Lys Asn Lys Arg Ala 
1               5                   10                  15      


Asn Ser Ser Gly Asp Glu Gln Glu Asn Gly Ala Gly Ala Leu Ala Ala 
            20                  25                  30          


Ala Gly Ala Ala Gly Ala Ala Ala Gly Gly Ala Leu Ala Ala Ala Ala 
        35                  40                  45              


Gly Cys Gly Ala Ala Ala Ala Gly Ala Pro Gly Ala Gly Gly Ala Ala 
    50                  55                  60                  


Gly Ala Gly Gly Ala Gly Thr Gly Ala Ala Asn Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Gly Ala Ala Ala Ala Gly Asp Ala Lys Asn Glu Ala Pro Cys Ala Thr 
                85                  90                  95      


Pro Leu Ile Cys Ser Phe Gly Arg Pro Val Asp Leu Glu Lys Asp Asp 
            100                 105                 110         


Tyr Gln Lys Val Val Cys Asn Asn Glu His Cys Pro Cys Ser Thr Trp 
        115                 120                 125             


Met His Leu Gln Cys Phe Tyr Glu Trp Glu Ser Ser Ile Leu Val Gln 
    130                 135                 140                 


Phe Asn Cys Ile Gly Arg Ala Arg Ser Trp Asn Glu Lys Gln Cys Arg 
145                 150                 155                 160 


Gln Asn Met Trp Thr Lys Lys Gly Tyr Asp Leu Ala Phe Arg Phe Cys 
                165                 170                 175     


Ser Cys Arg Cys Gly Gln Gly His Leu Lys Lys Asp Thr Asp Trp Tyr 
            180                 185                 190         


Gln Val Lys Arg Met Gln Asp Glu Lys Lys Lys Lys Ser Gly Ser Glu 
        195                 200                 205             


Lys Asn Thr Gly Arg Pro Pro Gly Glu Ala Ala Glu Glu Ala Lys Lys 
    210                 215                 220                 


Cys Arg Pro Pro Asn Lys Pro Gln Lys Gly Pro Ser His Asp Leu Pro 
225                 230                 235                 240 


Arg Arg His Ser Met Asp Arg Gln Asn Ser Gln Glu Lys Ala Val Gly 
                245                 250                 255     


Ala Ala Ala Tyr Gly Ala Arg Ser Pro Gly Gly Ser Pro Gly Gln Ser 
            260                 265                 270         


Pro Pro Thr Gly Tyr Ser Ile Leu Ser Pro Ala His Phe Ser Gly Pro 
        275                 280                 285             


Arg Ser Ser Arg Tyr Leu Gly Glu Phe Leu Lys Asn Ala Ile His Leu 
    290                 295                 300                 


Glu Pro His Lys Lys Ala Met Ala Gly Gly His Val Phe Arg Asn Ala 
305                 310                 315                 320 


His Phe Asp Tyr Ser Pro Ala Gly Leu Ala Val His Arg Gly Gly His 
                325                 330                 335     


Phe Asp Thr Pro Val Gln Phe Leu Arg Arg Leu Asp Leu Ser Glu Leu 
            340                 345                 350         


Leu Thr His Ile Pro Arg His Lys Leu Asn Thr Phe His Val Arg Met 
        355                 360                 365             


Glu Asp Asp Ala Gln Val Gly Gln Gly Glu Asp Leu Arg Lys Phe Ile 
    370                 375                 380                 


Leu Ala Ala Leu Ser Ala Ser His Arg Asn Val Val Asn Cys Ala Leu 
385                 390                 395                 400 


Cys His Arg Ala Leu Pro Val Phe Glu Gln Phe Pro Leu Val Asp Gly 
                405                 410                 415     


Thr Leu Phe Leu Ser Pro Ser Arg His Asp Glu Ile Glu Tyr Asp Val 
            420                 425                 430         


Pro Cys His Leu Gln Gly Arg Leu Met His Leu Tyr Ala Val Cys Val 
        435                 440                 445             


Asp Cys Leu Glu Gly Val His Lys Ile Ile Cys Ile Lys Cys Lys Ser 
    450                 455                 460                 


Arg Trp Asp Gly Ser Trp His Gln Leu Gly Thr Met Tyr Thr Tyr Asp 
465                 470                 475                 480 


Ile Leu Ala Ala Ser Pro Cys Cys Gln Ala Arg Leu Asn Cys Lys His 
                485                 490                 495     


Cys Gly Lys Pro Val Ile Asp Val Arg Ile Gly Met Gln Tyr Phe Ser 
            500                 505                 510         


Glu Tyr Ser Asn Val Gln Gln Cys Pro His Cys Gly Asn Leu Asp Tyr 
        515                 520                 525             


His Phe Val Lys Pro Phe Ser Ser Phe Lys Val Leu Glu Ala Tyr 
    530                 535                 540             


<210>  1875
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1875
tatgtttagt cccatatgct cttcctgaat cttgccactg cccatcaaga gatagaatac     60

atttcccctc cccttgaaca tggaagcaac caagctttaa gaagcacagc tttggagaca    120

ctccatgagt ctgcactgct ttcaggggaa ctagcactta agaccttgtg taacaaaatg    180

gacactgggg acacagctct aggacaaaaa gctacctcaa ggtctggaga aactgataaa    240

gcatcaggta gatggagaca ggaacaatca gctgttatta agatgagcac ttttggcagt    300

catgaaggac agcggcaacc acaaatagag cctgagcaaa tcggaaacac agcatcagca    360

caactgtttg gttctgggaa actggcctcc cctagtgaag tggtgcagca agtcgcagag    420

aagcaatatc caccgcatcg tccgagtcct tactcatgcc aacactcact ctctttccct    480

cagcactcat tgccacaggg ggtcatgcac agcaccaagc cacatcagag cctcgaaggt    540

cctccgtggc ttttccctgg ccctttgcca tccgttgcct ctgaggactt atttcctttt    600

cctatacatg gccacagtgg tggttatcct agaaaaaaga tttcaagtct gaaccctgct    660

tatagccaat actcccagaa aagtattgaa caggcagaag aggctcacaa gaaagagcac    720

aaacccaaaa agcctggcaa gtacatttgc ccttactgca gcagagcgtg tgccaaacct    780

agtgtactga aaaaacacat caggtcccat actggggagc ggccatatcc atgtatacct    840

tgtggtttct ctttcaagac aaagagcaat ttgtacaagc acaggaagtc acatgcccat    900

gcaattaagg caggattagt acctttcaca gagtcagctg tatctaaatt ggacctagag    960

gctggtttta ttgatgtaga agcagaaata cattcagatg gtgaacagag tacagacaca   1020

gatgaggaga gttctttatt tgccgaggct tctgacaaaa tgagtcctgg tccacccatc   1080

ccactggaca ttgccagcag aggcggctat catgggtcat tggaagaatc attgggaggt   1140

ccaatgaagg tgccgatttt gattatccct aaaagtggga ttcctctccc taatgaaagc   1200

tctcagtata ttggccctga tatgctacca aatccatctt taaatactaa ggctgatgat   1260

tcgcacacag tcaaacagaa acttgcacta agactgtcag agaaaaaagg acaagattct   1320

gagccatcgc tcaaccttct gagcccgcac agtaaaggaa gcactgattc tggttacttt   1380

tctcgctcag aaagtgctga gcagcaaata agccctccca acacaaatgc aaagtcttat   1440

gaagaaatca tctttggaaa atactgtcgg cttagtccga gaaatgcact cagtgttaca   1500

accacaagtc aggagcgtgc cgcaatgggt aggaagggca taatggaacc attacctcac   1560

gttaacacca ggttagatgt caagatgttt gaagatcctg tttcacagct gatcccaagc   1620

aagggagatg tcgaccccag tcaaacgagc atgctgaaat ccactaagtt caacagtgag   1680

tccagacaac cccagattat tccatcatct atcaggaacg aaggaaaact ttatccagca   1740

aacttccaag gcagcaaccc ggttctctta gaagctcctg tagactcttc accccttatt   1800

agaagcaact cagtgccaac ttcttcagca actaatctaa ctattcctcc ttctttgaga   1860

ggaagtcact catttgatga aaggatgact ggttccgacg atgtattcta tccagggacc   1920

gtgggcatac cccctcagcg catgctaaga agacaagcgg catttgagct gccttcggta   1980

caggagggcc acgtggaagt cgagcaccat ggcaggatgt tgaagggtat cagcagttca   2040

tccctgaagg aaaagaaatt gtctcctggg gacagggttg ggtatgacta tgatgtctgt   2100

cggaaaccct ataagaagtg ggaggactct gaaacaccaa agcaaaacta cagggacatt   2160

tcctgcttga gttctttaaa gcatggtgga gaatatttca tggatcccgt ggtgccattg   2220

cagggagtac caagcatgtt tggaactacc tgtgaaaaca ggaaacgccg gaaagagaag   2280

agcgtagggg atgaagagga cacgcccatg atctgcagca gcattgtaag cactcctgtg   2340

ggcatcatgg cttccgatta tgaccccaaa ctgcagatgc aggaaggagt caggagtgga   2400

tttgccatgg ctggacacga aaacctttct catggtcaca cggaacgctt tgacccatgt   2460

cggccccaac tgcagcctgg aagtccatct cttgtgtcag aggagtcacc ttcagccatt   2520

gattcagaca agatgtcaga cctagggggc aggaaacctc ctggaaatgt gatttctgtg   2580

attcagcaca ccaactcact gagccgaccc aattcatttg aaaggtctga gtcagccgaa   2640

cttgtggctt gcacacagga taaagcccct tccccttcag agacttgtga cagtgagatt   2700

tcagaagccc cagtgagtcc tgagtgggct ccacctgggg atggtgcaga aagtgggggg   2760

aaaccctctc catctcagca ggtgcagcag cagtcctatc acacacagcc caggctagtt   2820

cggcaacaca acatccaggt tcctgagatt cgagtgaccg aggagcctga taaacctgag   2880

aaggagaagg aagcccagag caaagagcca gagaagcctg tggaagaatt tcagtggccc   2940

cagagaagtg agaccctttc ccagctcccc gcggagaagt tgcctcccaa aaagaagcgt   3000

ctgcgacttg cagatatgga gcactcctca ggggagtcca gctttgaatc cacaggcaca   3060

ggcctctccc gcagccccag ccaagaaagc aacttgtccc acagctccag tttctccatg   3120

tcttttgaaa gagaagaaac cagtaagctt tctgcacttc ctaagcagga tgagtttggg   3180

aagcattcag agtttctgac tgtccctgct ggttcatact cattgtctgt cccaggccat   3240

caccaccaga aagagatgcg acgctgctca tcagagcaga tgccttgtcc tcacccagcg   3300

gaagtcccag aagttcggag caaatcattt gattatggga atctgtccca tgctcctgtg   3360

tcgggagcag cagcctccac ggtatcaccg tccagggaga ggaagaaatg ctttctggtg   3420

cggcaagctt ccttcagtgg ctccccagaa atctcccagg gcgaggttgg catggatcag   3480

agcgtgaagc aagagcagct ggagcacctg catgctggcc tccggtccgg gtggcaccat   3540

ggcccgcctg ctgtgctgcc tcctcttcag caagaggacc cagggaagca ggtggcgggt   3600

ccttgtcccc cgctgagctc ggggccactg cacctggccc agccacagat catgcacatg   3660

gacagtcagg aatctttgag aaatcccttg atccaaccaa catcctatat gacaagcaag   3720

cacttacctg aacagccaca cttatttcca catcaagaga caattccatt ttctccaatc   3780

cagaatgcct tgtttcagtt tcagtatcct acagtttgta tggttcattt accagctcag   3840

cagcctccct ggtggcaggc acatttccca catccctttg ctcagcaccc tcagaagagc   3900

tatggcaagc cctcttttca gacagaaatc cattcgagct atcccttaga gcatgtggca   3960

gagcacactg gaaagaaacc tgctgagtat gcacacacga aagagcagac ctacccatgt   4020

tattcaggag catcagggct acacccaaag aaccttcttc caaagtttcc atcagaccag   4080

agcagtaagt caactgaaac gccctctgag caggttcttc aagaagattt tgcctcggca   4140

aatgctgggt ctttgcagtc cctcccagga acagtggttc ctgttcggat ccagacgcac   4200

gtaccatcct atggaagtgt catgtacaca agcatttctc agatacttgg gcagaatagc   4260

cctgccattg tcatatgcaa agtcgatgag aatatgaccc aaaggacact ggtcaccaac   4320

gcagccatgc aagggatagg attcaacatt gcccaggtgc tggggcagca tgcgggcttg   4380

gagaagtacc ccatttggaa agcacctcag actttgcccc tcggcttaga atcctccatc   4440

cccttgtgtt taccttccac ctctgacagc gtggccaccc tgggaggtag caagcgaatg   4500

ctttctccag ccagtagctt ggagctcttc atggaaacca agcagcagaa aagggtcaaa   4560

gaagaaaaga tgtacggaca gattgtggag gagcttagtg ctgtggagct gaccaactca   4620

gacatcaaaa aggacctctc ccgcccccag aaaccccagc tggttcgaca aggatgtgct   4680

tctgagccaa aagatggctt gcagtcaggg tcatcttcct tctcctcgct gtcgccctcc   4740

tcatctcaag actatccttc tgttagcccg tcttccaggg agccattccc gcccagcaag   4800

gagatgcttt ccggttcccg ggcaccactt ccggggcaga agtccagtgg gccttctgaa   4860

agcaaagaat cttcagatga attagatatc gatgagacgg catcggacat gagcatgagc   4920

ccacagagtt cttcattacc agcaggagat ggtcagctgg aagaggaagg gaagggccac   4980

aagcggcctg ttggcatgct ggtccgcatg gcctctgccc ccagcgggaa cgtggcagac   5040

tcaactcttc ttctcacgga catggcagat ttccagcaga ttcttcagtt ccccagtctg   5100

cggacaacaa ctactgtgag ttggtgcttc ttgaattata caaaacccaa ttatgtgcaa   5160

caggccacct tcaaatcctc ggtttatgct tcatggtgca ttagttcctg taatccaaac   5220

ccatcaggat tgaacaccaa gaccacgctg gctcttctga ggtccaagca aaaaatcact   5280

gcagaaattt atactctggc tgctatgcat aggcctggaa ccggcaagct tacatcatca   5340

agtgcttgga agcagtttac tcagatgaaa cctgatgcgt cctttttatt tggcagcaaa   5400

ctagaaagga aactagtggg aaatatctta aaggaaagag ggaaaggaga tattcatgga   5460

gataaagata ttggatccaa acaaactgag ccaatccgaa ttaaaatatt tgaaggaggg   5520

tacaaatcga atgaagatta tgtatatgtc agaggacgtg gccggggaaa gtacatttgt   5580

gaagaatgtg ggattcgctg taagaagcca agcatgctca aaaaacacat ccgtacccat   5640

actgatgttc ggccttatgt atgcaagtta tgtaactttg ccttcaaaac gaaaggaaac   5700

ctaacgaagc atatgaaatc taaagcacac atgaaaaaat gcctggaatt gggagtctca   5760

atgacatcgg tggatgatac agaaactgag gaagcagaaa atttggaaga tttgcacaaa   5820

gcagcagaga agcatagcat gtccagcatt tcaactgatc atcagttctc cgatgctgag   5880

gaatcagatg gtgaggatgg agatgataat gatgatgatg atgaagatga agatgacttt   5940

gacgaccagg gagatttaac accaaaaaca agatcaagaa gcaccagtcc tcagcctcct   6000

agattctcct ccttgcctgt gaatgttggc gccgtacccc acggggttcc ttcagatagt   6060

tccctgggac attcttcgtt gatcagctat ttggttactt tgccaagtat tcgagttact   6120

cagcttatga cacccagtga ttcatgtgaa gatacccaga tgacagaata ccagaggcta   6180

ttccagagca aaagtacgga ctcagaacca gacaaagaca gattggacat acctagttgt   6240

atggatgagg agtgcatgct accttcagag ccaagctcct ctcccaggga cttctcaccc   6300

tcaagccacc attcctctcc aggatatgat tcttcaccct gtcgagataa ttcaccaaag   6360

aggtatctga tacccaaagg agatttatct cccaggagac atttatcacc taggagagat   6420

ctgtcaccca tgagacatct ttcaccaaca aaggaagctg cattgagaag agagatgtcc   6480

caaagagatg tttcaccaag aaggcatttg tctccaagga ggccagtgtc tcctgggaaa   6540

gatatcacag caagaagaga cctctcccct agaagagaga gaagatacat gaccacaata   6600

agagcgccat ctcccagaag ggctttatac cataacccac cattgtccat gggacagtat   6660

ttgcaagcag agccaattgt attggggcct cctaatttaa gaagaggatt acctcaggtt   6720

ccttacttca gtctctatgg agaccaagaa ggtgcttatg aacatccagg ctccagcctt   6780

ttccctgagg gtcctaatga ctatgtcttc agtcatcttc cactccactc tcagcaacaa   6840

gtgcgagccc ctatccccat ggtgcccgtt ggtgggatcc agatggttca ctccatgccg   6900

ccagcccttt ccagtttaca tccttcaccc acattgcccc tgccaatgga gggctttgag   6960

gagaagaaag gcgcgtcagg ggagtccttc tccaaggacc cctatgtgct ttctaagcag   7020

catgagaagc gaggtcctca cgctttgcag tcatctggtc cgcctagcac tccctcctct   7080

cctcggctgt tgatgaaaca gagcacttcg gaagacagcc taaacgcaac agagcgggaa   7140

caggaggaaa atatacagac ttgtacaaaa gccattgcct ctctccggat tgccacggaa   7200

gaggcagctc tgctcgggcc agatcagcca gcgcgggtgc aggagcccca ccagaacccc   7260

ctgggaagtg cacatgttag cattagacac tttagtagac ctgagccagg tcagccctgt   7320

acctcagcca cccaccctga cttgcatgat ggtgaaaagg acaattttgg tacatcacag   7380

actccattag ctcactccac gttttacagc aagagttgtg tggatgacaa gcagttggac   7440

tttcacagca gcaaggaatt atcttcaagc acagaggaaa gcaaagatcc ttcatcagaa   7500

aagagtcagc tacattgatc tatgatgcat ggagactttc atttccacat tttcccattt   7560

ttttgttttt gtttttctag aaatggaggt aatccagttt atagcatgcc tgtcctaagt   7620

tacagtagtt tgctattata tatacttttg ttatatcaaa agaattaggt aaattaacaa   7680

gtcatcatga gcctgaccaa aacaaaattt gaaattaacc tattgggtct ggtactttta   7740

aaattgtaca gatgtttgtg ccttttcttt actttgctta tattcttata agcatttttt   7800

agcagtaatt tgtacatatt ttagaatttg tgtatctgct ttgtaataaa tgtaatttct   7860

ttcctttttt ggacacttgg atctaaatga tgtaaagcaa aacagcatca atatatatgt   7920

gaggttgcac taaaacatat ttttatatga ttaaaactga acagctttta tgtacagctc   7980

tgattctgta atactaatat ttatttactt tgtttcataa attgtacatt ttttcttaat   8040

gttgtggatt gcttttctat gtgaagcatg ggatttactg ttgcgtaact agaacaaaaa   8100

tgtacattgt aaacaagata tttaaactag agtatcttat tctgcactta tgcattagtt   8160

aaaaaaagat aaaggatgta tcagtcagtt ct                                 8192


<210>  1876
<211>  2500
<212>  PRT
<213>  Homosapiens

<400>  1876

Met Leu Phe Leu Asn Leu Ala Thr Ala His Gln Glu Ile Glu Tyr Ile 
1               5                   10                  15      


Ser Pro Pro Leu Glu His Gly Ser Asn Gln Ala Leu Arg Ser Thr Ala 
            20                  25                  30          


Leu Glu Thr Leu His Glu Ser Ala Leu Leu Ser Gly Glu Leu Ala Leu 
        35                  40                  45              


Lys Thr Leu Cys Asn Lys Met Asp Thr Gly Asp Thr Ala Leu Gly Gln 
    50                  55                  60                  


Lys Ala Thr Ser Arg Ser Gly Glu Thr Asp Lys Ala Ser Gly Arg Trp 
65                  70                  75                  80  


Arg Gln Glu Gln Ser Ala Val Ile Lys Met Ser Thr Phe Gly Ser His 
                85                  90                  95      


Glu Gly Gln Arg Gln Pro Gln Ile Glu Pro Glu Gln Ile Gly Asn Thr 
            100                 105                 110         


Ala Ser Ala Gln Leu Phe Gly Ser Gly Lys Leu Ala Ser Pro Ser Glu 
        115                 120                 125             


Val Val Gln Gln Val Ala Glu Lys Gln Tyr Pro Pro His Arg Pro Ser 
    130                 135                 140                 


Pro Tyr Ser Cys Gln His Ser Leu Ser Phe Pro Gln His Ser Leu Pro 
145                 150                 155                 160 


Gln Gly Val Met His Ser Thr Lys Pro His Gln Ser Leu Glu Gly Pro 
                165                 170                 175     


Pro Trp Leu Phe Pro Gly Pro Leu Pro Ser Val Ala Ser Glu Asp Leu 
            180                 185                 190         


Phe Pro Phe Pro Ile His Gly His Ser Gly Gly Tyr Pro Arg Lys Lys 
        195                 200                 205             


Ile Ser Ser Leu Asn Pro Ala Tyr Ser Gln Tyr Ser Gln Lys Ser Ile 
    210                 215                 220                 


Glu Gln Ala Glu Glu Ala His Lys Lys Glu His Lys Pro Lys Lys Pro 
225                 230                 235                 240 


Gly Lys Tyr Ile Cys Pro Tyr Cys Ser Arg Ala Cys Ala Lys Pro Ser 
                245                 250                 255     


Val Leu Lys Lys His Ile Arg Ser His Thr Gly Glu Arg Pro Tyr Pro 
            260                 265                 270         


Cys Ile Pro Cys Gly Phe Ser Phe Lys Thr Lys Ser Asn Leu Tyr Lys 
        275                 280                 285             


His Arg Lys Ser His Ala His Ala Ile Lys Ala Gly Leu Val Pro Phe 
    290                 295                 300                 


Thr Glu Ser Ala Val Ser Lys Leu Asp Leu Glu Ala Gly Phe Ile Asp 
305                 310                 315                 320 


Val Glu Ala Glu Ile His Ser Asp Gly Glu Gln Ser Thr Asp Thr Asp 
                325                 330                 335     


Glu Glu Ser Ser Leu Phe Ala Glu Ala Ser Asp Lys Met Ser Pro Gly 
            340                 345                 350         


Pro Pro Ile Pro Leu Asp Ile Ala Ser Arg Gly Gly Tyr His Gly Ser 
        355                 360                 365             


Leu Glu Glu Ser Leu Gly Gly Pro Met Lys Val Pro Ile Leu Ile Ile 
    370                 375                 380                 


Pro Lys Ser Gly Ile Pro Leu Pro Asn Glu Ser Ser Gln Tyr Ile Gly 
385                 390                 395                 400 


Pro Asp Met Leu Pro Asn Pro Ser Leu Asn Thr Lys Ala Asp Asp Ser 
                405                 410                 415     


His Thr Val Lys Gln Lys Leu Ala Leu Arg Leu Ser Glu Lys Lys Gly 
            420                 425                 430         


Gln Asp Ser Glu Pro Ser Leu Asn Leu Leu Ser Pro His Ser Lys Gly 
        435                 440                 445             


Ser Thr Asp Ser Gly Tyr Phe Ser Arg Ser Glu Ser Ala Glu Gln Gln 
    450                 455                 460                 


Ile Ser Pro Pro Asn Thr Asn Ala Lys Ser Tyr Glu Glu Ile Ile Phe 
465                 470                 475                 480 


Gly Lys Tyr Cys Arg Leu Ser Pro Arg Asn Ala Leu Ser Val Thr Thr 
                485                 490                 495     


Thr Ser Gln Glu Arg Ala Ala Met Gly Arg Lys Gly Ile Met Glu Pro 
            500                 505                 510         


Leu Pro His Val Asn Thr Arg Leu Asp Val Lys Met Phe Glu Asp Pro 
        515                 520                 525             


Val Ser Gln Leu Ile Pro Ser Lys Gly Asp Val Asp Pro Ser Gln Thr 
    530                 535                 540                 


Ser Met Leu Lys Ser Thr Lys Phe Asn Ser Glu Ser Arg Gln Pro Gln 
545                 550                 555                 560 


Ile Ile Pro Ser Ser Ile Arg Asn Glu Gly Lys Leu Tyr Pro Ala Asn 
                565                 570                 575     


Phe Gln Gly Ser Asn Pro Val Leu Leu Glu Ala Pro Val Asp Ser Ser 
            580                 585                 590         


Pro Leu Ile Arg Ser Asn Ser Val Pro Thr Ser Ser Ala Thr Asn Leu 
        595                 600                 605             


Thr Ile Pro Pro Ser Leu Arg Gly Ser His Ser Phe Asp Glu Arg Met 
    610                 615                 620                 


Thr Gly Ser Asp Asp Val Phe Tyr Pro Gly Thr Val Gly Ile Pro Pro 
625                 630                 635                 640 


Gln Arg Met Leu Arg Arg Gln Ala Ala Phe Glu Leu Pro Ser Val Gln 
                645                 650                 655     


Glu Gly His Val Glu Val Glu His His Gly Arg Met Leu Lys Gly Ile 
            660                 665                 670         


Ser Ser Ser Ser Leu Lys Glu Lys Lys Leu Ser Pro Gly Asp Arg Val 
        675                 680                 685             


Gly Tyr Asp Tyr Asp Val Cys Arg Lys Pro Tyr Lys Lys Trp Glu Asp 
    690                 695                 700                 


Ser Glu Thr Pro Lys Gln Asn Tyr Arg Asp Ile Ser Cys Leu Ser Ser 
705                 710                 715                 720 


Leu Lys His Gly Gly Glu Tyr Phe Met Asp Pro Val Val Pro Leu Gln 
                725                 730                 735     


Gly Val Pro Ser Met Phe Gly Thr Thr Cys Glu Asn Arg Lys Arg Arg 
            740                 745                 750         


Lys Glu Lys Ser Val Gly Asp Glu Glu Asp Thr Pro Met Ile Cys Ser 
        755                 760                 765             


Ser Ile Val Ser Thr Pro Val Gly Ile Met Ala Ser Asp Tyr Asp Pro 
    770                 775                 780                 


Lys Leu Gln Met Gln Glu Gly Val Arg Ser Gly Phe Ala Met Ala Gly 
785                 790                 795                 800 


His Glu Asn Leu Ser His Gly His Thr Glu Arg Phe Asp Pro Cys Arg 
                805                 810                 815     


Pro Gln Leu Gln Pro Gly Ser Pro Ser Leu Val Ser Glu Glu Ser Pro 
            820                 825                 830         


Ser Ala Ile Asp Ser Asp Lys Met Ser Asp Leu Gly Gly Arg Lys Pro 
        835                 840                 845             


Pro Gly Asn Val Ile Ser Val Ile Gln His Thr Asn Ser Leu Ser Arg 
    850                 855                 860                 


Pro Asn Ser Phe Glu Arg Ser Glu Ser Ala Glu Leu Val Ala Cys Thr 
865                 870                 875                 880 


Gln Asp Lys Ala Pro Ser Pro Ser Glu Thr Cys Asp Ser Glu Ile Ser 
                885                 890                 895     


Glu Ala Pro Val Ser Pro Glu Trp Ala Pro Pro Gly Asp Gly Ala Glu 
            900                 905                 910         


Ser Gly Gly Lys Pro Ser Pro Ser Gln Gln Val Gln Gln Gln Ser Tyr 
        915                 920                 925             


His Thr Gln Pro Arg Leu Val Arg Gln His Asn Ile Gln Val Pro Glu 
    930                 935                 940                 


Ile Arg Val Thr Glu Glu Pro Asp Lys Pro Glu Lys Glu Lys Glu Ala 
945                 950                 955                 960 


Gln Ser Lys Glu Pro Glu Lys Pro Val Glu Glu Phe Gln Trp Pro Gln 
                965                 970                 975     


Arg Ser Glu Thr Leu Ser Gln Leu Pro Ala Glu Lys Leu Pro Pro Lys 
            980                 985                 990         


Lys Lys Arg Leu Arg Leu Ala Asp  Met Glu His Ser Ser  Gly Glu Ser 
        995                 1000                 1005             


Ser Phe  Glu Ser Thr Gly Thr  Gly Leu Ser Arg Ser  Pro Ser Gln 
    1010                 1015                 1020             


Glu Ser  Asn Leu Ser His Ser  Ser Ser Phe Ser Met  Ser Phe Glu 
    1025                 1030                 1035             


Arg Glu  Glu Thr Ser Lys Leu  Ser Ala Leu Pro Lys  Gln Asp Glu 
    1040                 1045                 1050             


Phe Gly  Lys His Ser Glu Phe  Leu Thr Val Pro Ala  Gly Ser Tyr 
    1055                 1060                 1065             


Ser Leu  Ser Val Pro Gly His  His His Gln Lys Glu  Met Arg Arg 
    1070                 1075                 1080             


Cys Ser  Ser Glu Gln Met Pro  Cys Pro His Pro Ala  Glu Val Pro 
    1085                 1090                 1095             


Glu Val  Arg Ser Lys Ser Phe  Asp Tyr Gly Asn Leu  Ser His Ala 
    1100                 1105                 1110             


Pro Val  Ser Gly Ala Ala Ala  Ser Thr Val Ser Pro  Ser Arg Glu 
    1115                 1120                 1125             


Arg Lys  Lys Cys Phe Leu Val  Arg Gln Ala Ser Phe  Ser Gly Ser 
    1130                 1135                 1140             


Pro Glu  Ile Ser Gln Gly Glu  Val Gly Met Asp Gln  Ser Val Lys 
    1145                 1150                 1155             


Gln Glu  Gln Leu Glu His Leu  His Ala Gly Leu Arg  Ser Gly Trp 
    1160                 1165                 1170             


His His  Gly Pro Pro Ala Val  Leu Pro Pro Leu Gln  Gln Glu Asp 
    1175                 1180                 1185             


Pro Gly  Lys Gln Val Ala Gly  Pro Cys Pro Pro Leu  Ser Ser Gly 
    1190                 1195                 1200             


Pro Leu  His Leu Ala Gln Pro  Gln Ile Met His Met  Asp Ser Gln 
    1205                 1210                 1215             


Glu Ser  Leu Arg Asn Pro Leu  Ile Gln Pro Thr Ser  Tyr Met Thr 
    1220                 1225                 1230             


Ser Lys  His Leu Pro Glu Gln  Pro His Leu Phe Pro  His Gln Glu 
    1235                 1240                 1245             


Thr Ile  Pro Phe Ser Pro Ile  Gln Asn Ala Leu Phe  Gln Phe Gln 
    1250                 1255                 1260             


Tyr Pro  Thr Val Cys Met Val  His Leu Pro Ala Gln  Gln Pro Pro 
    1265                 1270                 1275             


Trp Trp  Gln Ala His Phe Pro  His Pro Phe Ala Gln  His Pro Gln 
    1280                 1285                 1290             


Lys Ser  Tyr Gly Lys Pro Ser  Phe Gln Thr Glu Ile  His Ser Ser 
    1295                 1300                 1305             


Tyr Pro  Leu Glu His Val Ala  Glu His Thr Gly Lys  Lys Pro Ala 
    1310                 1315                 1320             


Glu Tyr  Ala His Thr Lys Glu  Gln Thr Tyr Pro Cys  Tyr Ser Gly 
    1325                 1330                 1335             


Ala Ser  Gly Leu His Pro Lys  Asn Leu Leu Pro Lys  Phe Pro Ser 
    1340                 1345                 1350             


Asp Gln  Ser Ser Lys Ser Thr  Glu Thr Pro Ser Glu  Gln Val Leu 
    1355                 1360                 1365             


Gln Glu  Asp Phe Ala Ser Ala  Asn Ala Gly Ser Leu  Gln Ser Leu 
    1370                 1375                 1380             


Pro Gly  Thr Val Val Pro Val  Arg Ile Gln Thr His  Val Pro Ser 
    1385                 1390                 1395             


Tyr Gly  Ser Val Met Tyr Thr  Ser Ile Ser Gln Ile  Leu Gly Gln 
    1400                 1405                 1410             


Asn Ser  Pro Ala Ile Val Ile  Cys Lys Val Asp Glu  Asn Met Thr 
    1415                 1420                 1425             


Gln Arg  Thr Leu Val Thr Asn  Ala Ala Met Gln Gly  Ile Gly Phe 
    1430                 1435                 1440             


Asn Ile  Ala Gln Val Leu Gly  Gln His Ala Gly Leu  Glu Lys Tyr 
    1445                 1450                 1455             


Pro Ile  Trp Lys Ala Pro Gln  Thr Leu Pro Leu Gly  Leu Glu Ser 
    1460                 1465                 1470             


Ser Ile  Pro Leu Cys Leu Pro  Ser Thr Ser Asp Ser  Val Ala Thr 
    1475                 1480                 1485             


Leu Gly  Gly Ser Lys Arg Met  Leu Ser Pro Ala Ser  Ser Leu Glu 
    1490                 1495                 1500             


Leu Phe  Met Glu Thr Lys Gln  Gln Lys Arg Val Lys  Glu Glu Lys 
    1505                 1510                 1515             


Met Tyr  Gly Gln Ile Val Glu  Glu Leu Ser Ala Val  Glu Leu Thr 
    1520                 1525                 1530             


Asn Ser  Asp Ile Lys Lys Asp  Leu Ser Arg Pro Gln  Lys Pro Gln 
    1535                 1540                 1545             


Leu Val  Arg Gln Gly Cys Ala  Ser Glu Pro Lys Asp  Gly Leu Gln 
    1550                 1555                 1560             


Ser Gly  Ser Ser Ser Phe Ser  Ser Leu Ser Pro Ser  Ser Ser Gln 
    1565                 1570                 1575             


Asp Tyr  Pro Ser Val Ser Pro  Ser Ser Arg Glu Pro  Phe Pro Pro 
    1580                 1585                 1590             


Ser Lys  Glu Met Leu Ser Gly  Ser Arg Ala Pro Leu  Pro Gly Gln 
    1595                 1600                 1605             


Lys Ser  Ser Gly Pro Ser Glu  Ser Lys Glu Ser Ser  Asp Glu Leu 
    1610                 1615                 1620             


Asp Ile  Asp Glu Thr Ala Ser  Asp Met Ser Met Ser  Pro Gln Ser 
    1625                 1630                 1635             


Ser Ser  Leu Pro Ala Gly Asp  Gly Gln Leu Glu Glu  Glu Gly Lys 
    1640                 1645                 1650             


Gly His  Lys Arg Pro Val Gly  Met Leu Val Arg Met  Ala Ser Ala 
    1655                 1660                 1665             


Pro Ser  Gly Asn Val Ala Asp  Ser Thr Leu Leu Leu  Thr Asp Met 
    1670                 1675                 1680             


Ala Asp  Phe Gln Gln Ile Leu  Gln Phe Pro Ser Leu  Arg Thr Thr 
    1685                 1690                 1695             


Thr Thr  Val Ser Trp Cys Phe  Leu Asn Tyr Thr Lys  Pro Asn Tyr 
    1700                 1705                 1710             


Val Gln  Gln Ala Thr Phe Lys  Ser Ser Val Tyr Ala  Ser Trp Cys 
    1715                 1720                 1725             


Ile Ser  Ser Cys Asn Pro Asn  Pro Ser Gly Leu Asn  Thr Lys Thr 
    1730                 1735                 1740             


Thr Leu  Ala Leu Leu Arg Ser  Lys Gln Lys Ile Thr  Ala Glu Ile 
    1745                 1750                 1755             


Tyr Thr  Leu Ala Ala Met His  Arg Pro Gly Thr Gly  Lys Leu Thr 
    1760                 1765                 1770             


Ser Ser  Ser Ala Trp Lys Gln  Phe Thr Gln Met Lys  Pro Asp Ala 
    1775                 1780                 1785             


Ser Phe  Leu Phe Gly Ser Lys  Leu Glu Arg Lys Leu  Val Gly Asn 
    1790                 1795                 1800             


Ile Leu  Lys Glu Arg Gly Lys  Gly Asp Ile His Gly  Asp Lys Asp 
    1805                 1810                 1815             


Ile Gly  Ser Lys Gln Thr Glu  Pro Ile Arg Ile Lys  Ile Phe Glu 
    1820                 1825                 1830             


Gly Gly  Tyr Lys Ser Asn Glu  Asp Tyr Val Tyr Val  Arg Gly Arg 
    1835                 1840                 1845             


Gly Arg  Gly Lys Tyr Ile Cys  Glu Glu Cys Gly Ile  Arg Cys Lys 
    1850                 1855                 1860             


Lys Pro  Ser Met Leu Lys Lys  His Ile Arg Thr His  Thr Asp Val 
    1865                 1870                 1875             


Arg Pro  Tyr Val Cys Lys Leu  Cys Asn Phe Ala Phe  Lys Thr Lys 
    1880                 1885                 1890             


Gly Asn  Leu Thr Lys His Met  Lys Ser Lys Ala His  Met Lys Lys 
    1895                 1900                 1905             


Cys Leu  Glu Leu Gly Val Ser  Met Thr Ser Val Asp  Asp Thr Glu 
    1910                 1915                 1920             


Thr Glu  Glu Ala Glu Asn Leu  Glu Asp Leu His Lys  Ala Ala Glu 
    1925                 1930                 1935             


Lys His  Ser Met Ser Ser Ile  Ser Thr Asp His Gln  Phe Ser Asp 
    1940                 1945                 1950             


Ala Glu  Glu Ser Asp Gly Glu  Asp Gly Asp Asp Asn  Asp Asp Asp 
    1955                 1960                 1965             


Asp Glu  Asp Glu Asp Asp Phe  Asp Asp Gln Gly Asp  Leu Thr Pro 
    1970                 1975                 1980             


Lys Thr  Arg Ser Arg Ser Thr  Ser Pro Gln Pro Pro  Arg Phe Ser 
    1985                 1990                 1995             


Ser Leu  Pro Val Asn Val Gly  Ala Val Pro His Gly  Val Pro Ser 
    2000                 2005                 2010             


Asp Ser  Ser Leu Gly His Ser  Ser Leu Ile Ser Tyr  Leu Val Thr 
    2015                 2020                 2025             


Leu Pro  Ser Ile Arg Val Thr  Gln Leu Met Thr Pro  Ser Asp Ser 
    2030                 2035                 2040             


Cys Glu  Asp Thr Gln Met Thr  Glu Tyr Gln Arg Leu  Phe Gln Ser 
    2045                 2050                 2055             


Lys Ser  Thr Asp Ser Glu Pro  Asp Lys Asp Arg Leu  Asp Ile Pro 
    2060                 2065                 2070             


Ser Cys  Met Asp Glu Glu Cys  Met Leu Pro Ser Glu  Pro Ser Ser 
    2075                 2080                 2085             


Ser Pro  Arg Asp Phe Ser Pro  Ser Ser His His Ser  Ser Pro Gly 
    2090                 2095                 2100             


Tyr Asp  Ser Ser Pro Cys Arg  Asp Asn Ser Pro Lys  Arg Tyr Leu 
    2105                 2110                 2115             


Ile Pro  Lys Gly Asp Leu Ser  Pro Arg Arg His Leu  Ser Pro Arg 
    2120                 2125                 2130             


Arg Asp  Leu Ser Pro Met Arg  His Leu Ser Pro Thr  Lys Glu Ala 
    2135                 2140                 2145             


Ala Leu  Arg Arg Glu Met Ser  Gln Arg Asp Val Ser  Pro Arg Arg 
    2150                 2155                 2160             


His Leu  Ser Pro Arg Arg Pro  Val Ser Pro Gly Lys  Asp Ile Thr 
    2165                 2170                 2175             


Ala Arg  Arg Asp Leu Ser Pro  Arg Arg Glu Arg Arg  Tyr Met Thr 
    2180                 2185                 2190             


Thr Ile  Arg Ala Pro Ser Pro  Arg Arg Ala Leu Tyr  His Asn Pro 
    2195                 2200                 2205             


Pro Leu  Ser Met Gly Gln Tyr  Leu Gln Ala Glu Pro  Ile Val Leu 
    2210                 2215                 2220             


Gly Pro  Pro Asn Leu Arg Arg  Gly Leu Pro Gln Val  Pro Tyr Phe 
    2225                 2230                 2235             


Ser Leu  Tyr Gly Asp Gln Glu  Gly Ala Tyr Glu His  Pro Gly Ser 
    2240                 2245                 2250             


Ser Leu  Phe Pro Glu Gly Pro  Asn Asp Tyr Val Phe  Ser His Leu 
    2255                 2260                 2265             


Pro Leu  His Ser Gln Gln Gln  Val Arg Ala Pro Ile  Pro Met Val 
    2270                 2275                 2280             


Pro Val  Gly Gly Ile Gln Met  Val His Ser Met Pro  Pro Ala Leu 
    2285                 2290                 2295             


Ser Ser  Leu His Pro Ser Pro  Thr Leu Pro Leu Pro  Met Glu Gly 
    2300                 2305                 2310             


Phe Glu  Glu Lys Lys Gly Ala  Ser Gly Glu Ser Phe  Ser Lys Asp 
    2315                 2320                 2325             


Pro Tyr  Val Leu Ser Lys Gln  His Glu Lys Arg Gly  Pro His Ala 
    2330                 2335                 2340             


Leu Gln  Ser Ser Gly Pro Pro  Ser Thr Pro Ser Ser  Pro Arg Leu 
    2345                 2350                 2355             


Leu Met  Lys Gln Ser Thr Ser  Glu Asp Ser Leu Asn  Ala Thr Glu 
    2360                 2365                 2370             


Arg Glu  Gln Glu Glu Asn Ile  Gln Thr Cys Thr Lys  Ala Ile Ala 
    2375                 2380                 2385             


Ser Leu  Arg Ile Ala Thr Glu  Glu Ala Ala Leu Leu  Gly Pro Asp 
    2390                 2395                 2400             


Gln Pro  Ala Arg Val Gln Glu  Pro His Gln Asn Pro  Leu Gly Ser 
    2405                 2410                 2415             


Ala His  Val Ser Ile Arg His  Phe Ser Arg Pro Glu  Pro Gly Gln 
    2420                 2425                 2430             


Pro Cys  Thr Ser Ala Thr His  Pro Asp Leu His Asp  Gly Glu Lys 
    2435                 2440                 2445             


Asp Asn  Phe Gly Thr Ser Gln  Thr Pro Leu Ala His  Ser Thr Phe 
    2450                 2455                 2460             


Tyr Ser  Lys Ser Cys Val Asp  Asp Lys Gln Leu Asp  Phe His Ser 
    2465                 2470                 2475             


Ser Lys  Glu Leu Ser Ser Ser  Thr Glu Glu Ser Lys  Asp Pro Ser 
    2480                 2485                 2490             


Ser Glu  Lys Ser Gln Leu His  
    2495                 2500 


<210>  1877
<211>  4196
<212>  DNA
<213>  Homosapiens

<400>  1877
cggccctccc atgtgcagcc cggccagccg ggctctcctc ctcgcggcgg atgggtgacc     60

ttttcctggc acgggcaggc tgtgggaggc agcggagcag gcgatgaaga agaagcagca    120

gcatcccggc ggcggcgcgg atccctggcc ccatggggcc cctatggggg gcgcccctcc    180

gggcctgggc agctggaagc gtcgggtgcc cctgctgcct ttcctgcgct tctccctccg    240

ggactacggc ttctgcatgg ccaccctgct ggtcttctgc ctgggctccc tcctctatca    300

gctcagcggg ggaccccctc gcttcctgct cgacctgcgg cagtacttgg gaaattccac    360

ttacttggat gaccatggac cacctcctag taaggtacta cctttcccaa gccaggtggt    420

gtacaacagg gtaggcaagt gtgggagccg tactgtggtc ttgcttctga gaatcttgtc    480

ggagaagcac ggatttaatt tggtcacatc agacattcac aacaaaacca ggcttactaa    540

aaatgaacaa atggaactga ttaaaaatat aagtactgcc gaacaaccct atttattcac    600

tcgacatgtt catttcctca acttctcaag gtttggagga gaccagcctg tctacatcaa    660

catcattaga gaccccgtca accggttctt atccaactat tttttccgtc gctttggaga    720

ctggagaggg gaacaaaatc acatgatccg cacccccagc atgaggcagg aggagcgcta    780

cctggatatc aatgagtgta ttcttgaaaa ctatcccgag tgctccaacc ccaggttatt    840

ttacatcatt ccgtactttt gtggacagca tcccagatgc agggagcctg gtgaatgggc    900

ccttgagaga gcaaagctga acgtgaatga aaacttcctg ctcgtgggga ttcttgaaga    960

gttggaagat gtgctgctgt tactggaaag atttttacct cattacttca agggcgtgct   1020

cagtatctac aaagacccag agcacaggaa gcttggaaac atgactgtga cggtgaagaa   1080

gactgtcccc tctcctgagg ctgtgcagat cctctaccag cggatgagat acgagtacga   1140

gttttaccac tacgtcaaag agcagttcca cctgctgaag cgcaagtttg gacttaagtc   1200

tcacgtcagc aagccccccc tgaggccaca cttctttatc ccaactccac tggaaaccga   1260

ggagccaatc gacgatgaag aacaggatga tgaaaagtgg ctggaagata tttataagag   1320

gtgatgtgac tgtgttgcct ctatggcttt atctcccttt tccagaaagt tctttgtttg   1380

gggaagtaaa atccttaagg gactaaatta atgcttgggt gcattaaaaa gaacaaaaca   1440

ttcccacatg ttggggtcat tgggagatgc ccggttttgc gggttttatt tgtttaattt   1500

tattctgtgt tttctcttgg ctctttgggt ctttcccggg tacactagat ggctccatcc   1560

caaggcatct tgtcataaaa cagctttccc ccaccccata tcatgggaaa agggggagaa   1620

atatagcccc tagcctaata acttatcatt tgtaaaatga cttataaaaa tattacctca   1680

atggtaggag acatccagac ttgtatattt cagtggaaat acaaaaccac ttcagagacc   1740

agggtatctc ctctggaagg atctaagaga aggtaagaca gattaggaca tcgaaaagga   1800

ggatggagcc aggtgccatg gcttgagcct ataatccgag gctgaggtgg gaggatcact   1860

tgagcccagg agtttgaggt tgcagtgagc tgtgatcaca ccactgcact ccagcctggg   1920

tgacagagtg agactctgtc tcaattaatt tttttttttt aaaggaggag gatctccatg   1980

ggtaagtggt ttctacccgc atgggtagag ttctgcctct ggtccttctc agggggcact   2040

ttcaccaaga gcagtgtaat tatctctgaa agagcaagtc agcttgtgcc gcatccccaa   2100

ccaatccaca gcctggagta cctttcaagg tcaaagtgca tggccagctc cattgagaca   2160

ttccatttca aagcaccgtg ctgacagata tcaaagtact ctagcaggga aaataatttg   2220

tttgctgtgt aaggaagaat gtagacaaga cagataaatc tgaaggtcat gtggcatcag   2280

ggaaagggca tggctgtgtc ttttgcaccc aatatgaaac atcttctccc aacactgctt   2340

taatggaagt tctaggaacc aatttagctc aggcatttga ctcctacagc agaagttctg   2400

agcctgacca cagatggtgt gtaatctatc aaacacaccc ctggccaagt tgggtcctat   2460

aggacctggt actatgtact attgtaactt ctagttccct aagaggtacc tgttttcagt   2520

aaaaaggggt cctgagttct gtgcaggtgg aagagctacc cgagaactac ctgagttctg   2580

tgcaggtaga gtcccatttc ttatgggacc tgtgtgctcc tgagaactct tacttgagac   2640

atcaaaaaga agcagcaaga gcttctggga cagagactgc ttggccagct ttgtaagtaa   2700

gtggctgcct ccaatgtgat gtgagtacat gttgggcagt ctcactgtcc taaggtatgt   2760

cttctttcca cctcccactg cccctcccct gccacctatc aatgatgcct tggttcagtc   2820

attagaaatc tgttgctttg agttctgaaa tattttcacc ttaaaaaaaa tgctgaaaat   2880

acacattctc ctgggaagac gataaacagc tagctaagaa gccgaggttc agtggtggca   2940

gcaggaagga cactgccaca aattttgtct atttcatatt tgtcccctag agccagccct   3000

agcaaatgtg tgagttggga gtagttaata gtaaataaga ctctgacttt acacaagcta   3060

cacattttat acttttcata aaccacaaag tctctctaga attttttctg ccttcactaa   3120

aattggactg tagccaagat ataaagcaag tcatttggaa cctgccgagt gagcactgaa   3180

gctactttat catgagatgt gtgttaagaa ggctgcagcc cacaggagtc cagggaaggc   3240

ggggaccaca gaggcacaga gtccagcact tggccgctca tgggccttct ttctgcctca   3300

gaggacgggg gcagagaagt gatgaaggga aatgttctta gaggaggaaa tatcctttgt   3360

cctgttcaga gagaccaggg ccctaccatt aggcatactt tcagaagcaa cctggagaac   3420

agctatcaat catattcaaa accagtacaa gaactgctgc ctggtaccct gtgagtcatt   3480

tctatgaaat tccatataaa gaatgatgat aagtttacac actgtgcaat ctcacaatct   3540

gaaaataaag ttgagttggc tgtgttttct ctgctcttgt cagaacattg ggacaattgg   3600

tcgttcaaaa acattcatcc tcttactgca agtttatctg ggtactttta cctgtgtgtt   3660

caaaggcatt tcttttcagc agtgatcatt ataacttcac aaaaaaagat gctgacggat   3720

ttacttacag ggccttaatg ttattttgtc ccagccaaca ccctctaggt cctaaaagtc   3780

aaggtacttc agtttatttg gcaaacatga caacattttt ttggccctgg gcccaacagt   3840

ttgtacttca tgaaacatat tgtacatttt acatagttta atttaaaaaa taccttttaa   3900

gctagttgat ctttgactgt cttatttatt ataacctttc agcacattcc aaggttttag   3960

ttactcagga aggagttaat taaaatgatt ttattttggt ctgatggatg ttttttaaaa   4020

ggaaaattat tattatgaac cttcagccta ctttcttgag tgccgtaaaa gtgcttgtaa   4080

atcttttttt ttttttaaga agaaagaaaa aaatggtgtt tgacgttgat ggaaattcaa   4140

aaatatatat ggaactgaaa cattaactta gctaaaataa aagcaatctg tgtttg       4196


<210>  1878
<211>  406
<212>  PRT
<213>  Homosapiens

<400>  1878

Met Lys Lys Lys Gln Gln His Pro Gly Gly Gly Ala Asp Pro Trp Pro 
1               5                   10                  15      


His Gly Ala Pro Met Gly Gly Ala Pro Pro Gly Leu Gly Ser Trp Lys 
            20                  25                  30          


Arg Arg Val Pro Leu Leu Pro Phe Leu Arg Phe Ser Leu Arg Asp Tyr 
        35                  40                  45              


Gly Phe Cys Met Ala Thr Leu Leu Val Phe Cys Leu Gly Ser Leu Leu 
    50                  55                  60                  


Tyr Gln Leu Ser Gly Gly Pro Pro Arg Phe Leu Leu Asp Leu Arg Gln 
65                  70                  75                  80  


Tyr Leu Gly Asn Ser Thr Tyr Leu Asp Asp His Gly Pro Pro Pro Ser 
                85                  90                  95      


Lys Val Leu Pro Phe Pro Ser Gln Val Val Tyr Asn Arg Val Gly Lys 
            100                 105                 110         


Cys Gly Ser Arg Thr Val Val Leu Leu Leu Arg Ile Leu Ser Glu Lys 
        115                 120                 125             


His Gly Phe Asn Leu Val Thr Ser Asp Ile His Asn Lys Thr Arg Leu 
    130                 135                 140                 


Thr Lys Asn Glu Gln Met Glu Leu Ile Lys Asn Ile Ser Thr Ala Glu 
145                 150                 155                 160 


Gln Pro Tyr Leu Phe Thr Arg His Val His Phe Leu Asn Phe Ser Arg 
                165                 170                 175     


Phe Gly Gly Asp Gln Pro Val Tyr Ile Asn Ile Ile Arg Asp Pro Val 
            180                 185                 190         


Asn Arg Phe Leu Ser Asn Tyr Phe Phe Arg Arg Phe Gly Asp Trp Arg 
        195                 200                 205             


Gly Glu Gln Asn His Met Ile Arg Thr Pro Ser Met Arg Gln Glu Glu 
    210                 215                 220                 


Arg Tyr Leu Asp Ile Asn Glu Cys Ile Leu Glu Asn Tyr Pro Glu Cys 
225                 230                 235                 240 


Ser Asn Pro Arg Leu Phe Tyr Ile Ile Pro Tyr Phe Cys Gly Gln His 
                245                 250                 255     


Pro Arg Cys Arg Glu Pro Gly Glu Trp Ala Leu Glu Arg Ala Lys Leu 
            260                 265                 270         


Asn Val Asn Glu Asn Phe Leu Leu Val Gly Ile Leu Glu Glu Leu Glu 
        275                 280                 285             


Asp Val Leu Leu Leu Leu Glu Arg Phe Leu Pro His Tyr Phe Lys Gly 
    290                 295                 300                 


Val Leu Ser Ile Tyr Lys Asp Pro Glu His Arg Lys Leu Gly Asn Met 
305                 310                 315                 320 


Thr Val Thr Val Lys Lys Thr Val Pro Ser Pro Glu Ala Val Gln Ile 
                325                 330                 335     


Leu Tyr Gln Arg Met Arg Tyr Glu Tyr Glu Phe Tyr His Tyr Val Lys 
            340                 345                 350         


Glu Gln Phe His Leu Leu Lys Arg Lys Phe Gly Leu Lys Ser His Val 
        355                 360                 365             


Ser Lys Pro Pro Leu Arg Pro His Phe Phe Ile Pro Thr Pro Leu Glu 
    370                 375                 380                 


Thr Glu Glu Pro Ile Asp Asp Glu Glu Gln Asp Asp Glu Lys Trp Leu 
385                 390                 395                 400 


Glu Asp Ile Tyr Lys Arg 
                405     


<210>  1879
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  1879
cggccgccgc cggcacccac agcgccaaga gcggcggctc cgaggcggct ctcaaggagg     60

gtggaagcgc cgccgcgctg tcctcctcct cctcctcctc cgcggcggca gcggcggcat    120

cctcttcctc ctcgtcgggc ccgggctcgg ccatggagac ggggctgctc cccaaccaca    180

aactgaaaac cgttggcgaa gcccccgccg cgccgcccca ccagcagcac caccaccacc    240

accatgccca ccaccaccac caccatgccc accacctcca ccaccaccac gcactacagc    300

agcagctaaa ccagttccag cagcagcagc agcagcagca acagcagcag cagcagcagc    360

agcaacagca acatcccatt tccaacaaca acagcttggg cggcgcgggc ggcggcgcgc    420

ctcagcccgg ccccgacatg gagcagccgc aacatggagg cgccaaggac agtgctgcgg    480

gcggccaggc cgaccccccg ggcccgccgc tgctgagcaa gccgggcgac gaggacgacg    540

cgccgcccaa gatgggggag ccggcgggcg gccgctacga gcacccgggc ttgggcgccc    600

tgggcacgca gcagccgccg gtcgccgtgc ccgggggcgg cggcggcccg gcggccgtcc    660

cggagtttaa taattactat ggcagcgctg cccctgcgag cggcggcccc ggcggccgcg    720

ctgggccttg ctttgatcaa catggcggac aacaaagccc cgggatgggg atgatgcact    780

ccgcctccgc cgccgccgcc ggggcccccg gcagcatgga ccccctgcag aactcccacg    840

aagggtaccc caacagccag tgcaaccatt atccgggcta cagccggccc ggcgcgggcg    900

gcggcggcgg cggcggcggc ggaggaggag gaggcagcgg aggaggagga ggaggaggag    960

gagcaggagc aggaggagca ggagcgggag ctgtggcggc ggcggccgcg gcggcggcgg   1020

cagcagcagg aggcggcggc ggcggcggct atgggggctc gtccgcgggg tacggggtgc   1080

tgagctcccc ccggcagcag ggcggcggca tgatgatggg ccccgggggc ggcggggccg   1140

cgagcctcag caaggcggcc gccggctcgg cggcgggggg cttccagcgc ttcgccggcc   1200

agaaccagca cccgtcgggg gccaccccga ccctcaatca gctgctcacc tcgcccagcc   1260

ccatgatgcg gagctacggc ggcagctacc ccgagtacag cagccccagc gcgccgccgc   1320

cgccgccgtc gcagccccag tcccaggcgg cggcggcggg ggcggcggcg ggcggccagc   1380

aggcggccgc gggcatgggc ttgggcaagg acatgggcgc ccagtacgcc gctgccagcc   1440

cggcctgggc ggccgcgcaa caaaggagtc acccggcgat gagccccggc acccccggac   1500

cgaccatggg cagatcccag ggcagcccaa tggatccaat ggtgatgaag agacctcagt   1560

tgtatggcat gggcagtaac cctcattctc agcctcagca gagcagtccg tacccaggag   1620

gttcctatgg ccctccaggc ccacagcggt atccaattgg catccagggt cggactcccg   1680

gggccatggc cggaatgcag taccctcagc agcagatgcc acctcagtat ggacagcaag   1740

gtgtgagtgg ttactgccag cagggccaac agccatatta cagccagcag ccgcagcccc   1800

cgcacctccc accccaggcg cagtatctgc cgtcccagtc ccagcagagg taccagccgc   1860

agcaggacat gtctcaggaa ggctatggaa ctagatctca acctcctctg gcccccggaa   1920

aacctaacca tgaagacttg aacttaatac agcaagaaag accatcaagt ttaccagatc   1980

tgtctggctc cattgatgac ctccccacgg gaacggaagc aactttgagc tcagcagtca   2040

gtgcatccgg gtccacgagc agccaagggg atcagagcaa cccggcgcag tcgcctttct   2100

ccccacatgc gtcccctcat ctctccagca tcccgggggg cccatctccc tctcctgttg   2160

gctctcctgt aggaagcaac cagtctcgat ctggcccaat ctctcctgca agtatcccag   2220

gtagtcagat gcctccgcag ccacccggga gccagtcaga atccagttcc catcccgcct   2280

tgagccagtc accaatgcca caggaaagag gttttatggc aggcacacaa agaaaccctc   2340

agatggctca gtatggacct caacagacag gaccatccat gtcgcctcat ccttctcctg   2400

ggggccagat gcatgctgga atcagtagct ttcagcagag taactcaagt gggacttacg   2460

gtccacagat gagccagtat ggaccacaag gtaactactc cagaccccca gcgtatagtg   2520

gggtgcccag tgcaagctac agcggcccag ggcccggtat gggtatcagt gccaacaacc   2580

agatgcatgg acaagggcca agccagccat gtggtgctgt gcccctggga cgaatgccat   2640

cagctgggat gcagaacaga ccatttcctg gaaatatgag cagcatgacc cccagttctc   2700

ctggcatgtc tcagcaggga gggccaggaa tggggccgcc aatgccaact gtgaaccgta   2760

aggcacagga ggcagccgca gcagtgatgc aggctgctgc gaactcagca caaagcaggc   2820

aaggcagttt ccccggcatg aaccagagtg gacttatggc ttccagctct ccctacagcc   2880

agcccatgaa caacagctct agcctgatga acacgcaggc gccgccctac agcatggcgc   2940

ccgccatggt gaacagctcg gcagcatctg tgggtcttgc agatatgatg tctcctggtg   3000

aatccaaact gcccctgcct ctcaaagcag acggcaaaga agaaggcact ccacagcccg   3060

agagcaagtc aaaggatagc tacagctctc agggtatttc tcagccccca accccaggca   3120

acctgccagt cccttcccca atgtccccca gctctgctag catctcctca tttcatggag   3180

atgaaagtga tagcattagc agcccaggct ggccaaagac tccatcaagc cctaagtcca   3240

gctcctccac cactactggg gagaagatca cgaaggtgta cgagctgggg aatgagccag   3300

agagaaagct ctgggtcgac cgatacctca ccttcatgga agagagaggc tctcctgtct   3360

caagtctgcc tgccgtgggc aagaagcccc tggacctgtt ccgactctac gtctgcgtca   3420

aagagatcgg gggtttggcc caggttaata aaaacaagaa gtggcgtgag ctggcaacca   3480

acctaaacgt tggcacctca agcagtgcag cgagctccct gaaaaagcag tatattcagt   3540

acctgtttgc ctttgagtgc aagatcgaac gtggggagga gcccccgccg gaagtcttca   3600

gcaccgggga caccaaaaag cagcccaagc tccagccgcc atctcctgct aactcgggat   3660

ccttgcaagg cccacagacc ccccagtcaa ctggcagcaa ttccatggca gaggttccag   3720

gtgacctgaa gccacctacc ccagcctcca cccctcacgg ccagatgact ccaatgcaag   3780

gtggaagaag cagtacaatc agtgtgcacg acccattctc agatgtgagt gattcatcct   3840

tcccgaaacg gaactccatg actccaaacg ccccctacca gcagggcatg agcatgcccg   3900

atgtgatggg caggatgccc tatgagccca acaaggaccc ctttggggga atgagaaaag   3960

tgcctggaag cagcgagccc tttatgacgc aaggacagat gcccaacagc agcatgcagg   4020

acatgtacaa ccaaagtccc tccggagcaa tgtctaacct gggcatgggg cagcgccagc   4080

agtttcccta tggagccagt tacgaccgaa ggcatgaacc ttatgggcag cagtatccag   4140

gccaaggccc tccctcggga cagccgccgt atggagggca ccagcccggc ctgtacccac   4200

agcagccgaa ttacaaacgc catatggacg gcatgtacgg gcccccagcc aagcgccacg   4260

agggcgacat gtacaacatg cagtacagca gccagcagca ggagatgtac aaccagtatg   4320

gaggctccta ctcgggcccg gaccgcaggc ccatccaggg ccagtacccg tatccctaca   4380

gcagggagag gatgcagggc ccggggcaga tccagacaca cggaatcccg cctcagatga   4440

tgggcggccc gctgcagtcg tcctccagtg aggggcctca gcagaatatg tgggcagcac   4500

gcaatgatat gccttatccc taccagaaca ggcagggccc tggcggccct acacaggcgc   4560

ccccttaccc aggcatgaac cgcacagacg atatgatggt acccgatcag aggataaatc   4620

atgagagcca gtggccttct cacgtcagcc agcgtcagcc ttatatgtcg tcctcagcct   4680

ccatgcagcc catcacacgc ccaccacagc cgtcctacca gacgccaccg tcactgccaa   4740

atcacatctc cagggcgccc agcccagcgt ccttccagcg ctccctggag aaccgcatgt   4800

ctccaagcaa gtctcctttt ctgccgtcta tgaagatgca gaaggtcatg cccacggtcc   4860

ccacatccca ggtcaccggg ccaccacccc aaccaccccc aatcagaagg gagatcacct   4920

ttcctcctgg ctcagtagaa gcatcacaac cagtcttgaa acaaaggcga aagattacct   4980

ccaaagatat cgttactcct gaggcgtggc gtgtgatgat gtcccttaaa tcaggtcttt   5040

tggctgagag tacgtgggct ttggacacta ttaatattct tctgtatgat gacagcactg   5100

ttgctacttt caatctctcc cagttgtctg gatttctcga acttttagtc gagtacttta   5160

gaaaatgcct gattgacatt tttggaattc ttatggaata tgaagtggga gaccccagcc   5220

aaaaagcact tgatcacaac gcagcaagga aggatgacag ccagtccttg gcagacgatt   5280

ctgggaaaga ggaggaagat gctgaatgta ttgatgacga cgaggaagac gaggaggatg   5340

aggaggaaga cagcgagaag acagaaagcg atgaaaagag cagcatcgct ctgactgccc   5400

cggacgccgc tgcagaccca aaggagaagc ccaagcaagc cagtaagttc gacaagctgc   5460

caataaagat agtcaaaaag aacaacctgt ttgttgttga ccgatctgac aagttggggc   5520

gtgtgcagga gttcaatagt ggccttctgc actggcagct cggcgggggt gacaccaccg   5580

agcacattca gactcacttt gagagcaaga tggaaattcc tcctcgcagg cgcccacctc   5640

cccccttaag ctccgcaggt agaaagaaag agcaagaagg caaaggcgac tctgaagagc   5700

agcaagagaa aagcatcata gcaaccatcg atgacgtcct ctctgctcgg ccaggggcat   5760

tgcctgaaga cgcaaaccct gggccccaga ccgaaagcag taagtttccc tttggtatcc   5820

agcaagccaa aagtcaccgg aacatcaagc tgctggagga cgagcccagg agccgagacg   5880

agactcctct gtgtaccatc gcgcactggc aggactcgct ggctaagcga tgcatctgtg   5940

tgtccaatat tgtccgtagc ttgtcattcg tgcctggcaa tgatgccgaa atgtccaaac   6000

atccaggcct ggtgctgatc ctggggaagc tgattcttct tcaccacgag catccagaga   6060

gaaagcgagc accgcagacc tatgagaaag aggaggatga ggacaagggg gtggcctgca   6120

gcaaagatga gtggtggtgg gactgcctcg aggtcttgag ggataacacg ttggtcacgt   6180

tggccaacat ttccgggcag ctagacttgt ctgcttacac ggaaagcatc tgcttgccaa   6240

ttttggatgg cttgctgcac tggatggtgt gcccgtctgc agaggcacaa gatccctttc   6300

caactgtggg acccaactcg gtcctgtcgc ctcagagact tgtgctggag accctctgta   6360

aactcagtat ccaggacaat aatgtggacc tgatcttggc cactcctcca tttagtcgtc   6420

aggagaaatt ctatgctaca ttagttaggt acgttgggga tcgcaaaaac ccagtctgtc   6480

gagaaatgtc catggcgctt ttatcgaacc ttgcccaagg ggacgcacta gcagcaaggg   6540

ccatagctgt gcagaaagga agcattggaa acttgataag cttcctagag gatggggtca   6600

cgatggccca gtaccagcag agccagcaca acctcatgca catgcagccc ccgcccctgg   6660

aaccacctag cgtagacatg atgtgcaggg cggccaaggc tttgctagcc atggccagag   6720

tggacgaaaa ccgctcggaa ttccttttgc acgagggccg gttgctggat atctcgatat   6780

cagctgtcct gaactctctg gttgcatctg tcatctgtga tgtactgttt cagattgggc   6840

agttatgaca taagtgagaa ggcaagcatg tgtgagtgaa gattagaggg tcacatataa   6900

ctggctgttt tctgttcttg tttatccagc gtaggaagaa ggaaaagaaa atctttgctc   6960

ctctgcccca ttcactattt accaattggg aattaaagaa ataattaatt tgaacagtta   7020

tgaaattaat atttgctgtc tgtgtgtata agtacatcct ttggggtttt ttttttctct   7080

tttttttaac caaagttgct gtctagtgca ttcaaaggtc actttttgtt cttcacagat   7140

ctttttaatg ttctttccca tgttgtattg catttttggg ggaagcaaat tgactttaaa   7200

gaaaaaagtt gtggcaaaag atgctaagat gcgaaaattt caccacactg agtcaaaaag   7260

gtgaaaaatt atccatttcc tatgcgtttt actcctcaga gaatgaaaaa aactgcatcc   7320

catcacccaa agttctgtgc aatagaaatt tctacagata caggtatagg ggctcaagga   7380

ggtatgtcgg tcagtagtca aaactatgaa atgatactgg tttctccaca ggaatatggt   7440

tccattaggc tgggagcaaa aacaatgttt tttaagattg agaatacata cctgacaacg   7500

atccggaaac tgctcctcac cactcccgtc atgcctgctg tcggcgtttg accttccacg   7560

tgacagttct tcacaattcc tttcatcatt ttttaaatat tttttttact gcctatgggc   7620

tgtgatgtat atagaagttg tacattaaac ataccctcat ttttttcttt tctttttttt   7680

tttttttttt agtacaaagt tttagtttct ttttcatgat gtggtaacta cgaagtgatg   7740

gtagatttaa ataatttttt atttttattt tatatatttt ttcattaggg ccatatctcc   7800

aaaaaaagaa agaaaaaata caaaaaacaa aaacaaaaaa aaaagagggt aatgtacaag   7860

tttctgtatg tataaagtca tgctcgattt caggagagca gctgatcaca atttgcttca   7920

tgaatcaagg tgtggaaatg gttatatatg gattgattta gaaaatggtt accagtacag   7980

tcaaaaaaga gaaaatgaaa aaaatacaac taaaaggaag aaacacaact tcaaagattt   8040

ttcagtgatg agaatccaca tttgtatttc aagataatgt agtttaaaaa aaaaaaaaag   8100

aaaaaaactt gatgtaaatt cctccttttc ctctggctta atgaatatca tttattcagt   8160

ataaaatctt tatatgttcc acatgttaag aa                                 8192


<210>  1880
<211>  2231
<212>  PRT
<213>  Homosapiens

<400>  1880

Met Glu Thr Gly Leu Leu Pro Asn His Lys Leu Lys Thr Val Gly Glu 
1               5                   10                  15      


Ala Pro Ala Ala Pro Pro His Gln Gln His His His His His His Ala 
            20                  25                  30          


His His His His His His Ala His His Leu His His His His Ala Leu 
        35                  40                  45              


Gln Gln Gln Leu Asn Gln Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln His Pro Ile Ser Asn Asn Asn 
65                  70                  75                  80  


Ser Leu Gly Gly Ala Gly Gly Gly Ala Pro Gln Pro Gly Pro Asp Met 
                85                  90                  95      


Glu Gln Pro Gln His Gly Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln 
            100                 105                 110         


Ala Asp Pro Pro Gly Pro Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp 
        115                 120                 125             


Asp Ala Pro Pro Lys Met Gly Glu Pro Ala Gly Gly Arg Tyr Glu His 
    130                 135                 140                 


Pro Gly Leu Gly Ala Leu Gly Thr Gln Gln Pro Pro Val Ala Val Pro 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Pro Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr 
                165                 170                 175     


Gly Ser Ala Ala Pro Ala Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro 
            180                 185                 190         


Cys Phe Asp Gln His Gly Gly Gln Gln Ser Pro Gly Met Gly Met Met 
        195                 200                 205             


His Ser Ala Ser Ala Ala Ala Ala Gly Ala Pro Gly Ser Met Asp Pro 
    210                 215                 220                 


Leu Gln Asn Ser His Glu Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr 
225                 230                 235                 240 


Pro Gly Tyr Ser Arg Pro Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly 
            260                 265                 270         


Ala Gly Gly Ala Gly Ala Gly Ala Val Ala Ala Ala Ala Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser 
    290                 295                 300                 


Ala Gly Tyr Gly Val Leu Ser Ser Pro Arg Gln Gln Gly Gly Gly Met 
305                 310                 315                 320 


Met Met Gly Pro Gly Gly Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala 
                325                 330                 335     


Ala Gly Ser Ala Ala Gly Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln 
            340                 345                 350         


His Pro Ser Gly Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro 
        355                 360                 365             


Ser Pro Met Met Arg Ser Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser 
    370                 375                 380                 


Pro Ser Ala Pro Pro Pro Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala 
385                 390                 395                 400 


Ala Ala Gly Ala Ala Ala Gly Gly Gln Gln Ala Ala Ala Gly Met Gly 
                405                 410                 415     


Leu Gly Lys Asp Met Gly Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp 
            420                 425                 430         


Ala Ala Ala Gln Gln Arg Ser His Pro Ala Met Ser Pro Gly Thr Pro 
        435                 440                 445             


Gly Pro Thr Met Gly Arg Ser Gln Gly Ser Pro Met Asp Pro Met Val 
    450                 455                 460                 


Met Lys Arg Pro Gln Leu Tyr Gly Met Gly Ser Asn Pro His Ser Gln 
465                 470                 475                 480 


Pro Gln Gln Ser Ser Pro Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly 
                485                 490                 495     


Pro Gln Arg Tyr Pro Ile Gly Ile Gln Gly Arg Thr Pro Gly Ala Met 
            500                 505                 510         


Ala Gly Met Gln Tyr Pro Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln 
        515                 520                 525             


Gln Gly Val Ser Gly Tyr Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser 
    530                 535                 540                 


Gln Gln Pro Gln Pro Pro His Leu Pro Pro Gln Ala Gln Tyr Leu Pro 
545                 550                 555                 560 


Ser Gln Ser Gln Gln Arg Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu 
                565                 570                 575     


Gly Tyr Gly Thr Arg Ser Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn 
            580                 585                 590         


His Glu Asp Leu Asn Leu Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro 
        595                 600                 605             


Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr 
    610                 615                 620                 


Leu Ser Ser Ala Val Ser Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp 
625                 630                 635                 640 


Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Ala Ser Pro His 
                645                 650                 655     


Leu Ser Ser Ile Pro Gly Gly Pro Ser Pro Ser Pro Val Gly Ser Pro 
            660                 665                 670         


Val Gly Ser Asn Gln Ser Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile 
        675                 680                 685             


Pro Gly Ser Gln Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser 
    690                 695                 700                 


Ser Ser His Pro Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly 
705                 710                 715                 720 


Phe Met Ala Gly Thr Gln Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro 
                725                 730                 735     


Gln Gln Thr Gly Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly Gln 
            740                 745                 750         


Met His Ala Gly Ile Ser Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr 
        755                 760                 765             


Tyr Gly Pro Gln Met Ser Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg 
    770                 775                 780                 


Pro Pro Ala Tyr Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly 
785                 790                 795                 800 


Pro Gly Met Gly Ile Ser Ala Asn Asn Gln Met His Gly Gln Gly Pro 
                805                 810                 815     


Ser Gln Pro Cys Gly Ala Val Pro Leu Gly Arg Met Pro Ser Ala Gly 
            820                 825                 830         


Met Gln Asn Arg Pro Phe Pro Gly Asn Met Ser Ser Met Thr Pro Ser 
        835                 840                 845             


Ser Pro Gly Met Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met 
    850                 855                 860                 


Pro Thr Val Asn Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met Gln 
865                 870                 875                 880 


Ala Ala Ala Asn Ser Ala Gln Ser Arg Gln Gly Ser Phe Pro Gly Met 
                885                 890                 895     


Asn Gln Ser Gly Leu Met Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met 
            900                 905                 910         


Asn Asn Ser Ser Ser Leu Met Asn Thr Gln Ala Pro Pro Tyr Ser Met 
        915                 920                 925             


Ala Pro Ala Met Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala Asp 
    930                 935                 940                 


Met Met Ser Pro Gly Glu Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp 
945                 950                 955                 960 


Gly Lys Glu Glu Gly Thr Pro Gln Pro Glu Ser Lys Ser Lys Asp Ser 
                965                 970                 975     


Tyr Ser Ser Gln Gly Ile Ser Gln Pro Pro Thr Pro Gly Asn Leu Pro 
            980                 985                 990         


Val Pro Ser Pro Met Ser Pro Ser  Ser Ala Ser Ile Ser  Ser Phe His 
        995                 1000                 1005             


Gly Asp  Glu Ser Asp Ser Ile  Ser Ser Pro Gly Trp  Pro Lys Thr 
    1010                 1015                 1020             


Pro Ser  Ser Pro Lys Ser Ser  Ser Ser Thr Thr Thr  Gly Glu Lys 
    1025                 1030                 1035             


Ile Thr  Lys Val Tyr Glu Leu  Gly Asn Glu Pro Glu  Arg Lys Leu 
    1040                 1045                 1050             


Trp Val  Asp Arg Tyr Leu Thr  Phe Met Glu Glu Arg  Gly Ser Pro 
    1055                 1060                 1065             


Val Ser  Ser Leu Pro Ala Val  Gly Lys Lys Pro Leu  Asp Leu Phe 
    1070                 1075                 1080             


Arg Leu  Tyr Val Cys Val Lys  Glu Ile Gly Gly Leu  Ala Gln Val 
    1085                 1090                 1095             


Asn Lys  Asn Lys Lys Trp Arg  Glu Leu Ala Thr Asn  Leu Asn Val 
    1100                 1105                 1110             


Gly Thr  Ser Ser Ser Ala Ala  Ser Ser Leu Lys Lys  Gln Tyr Ile 
    1115                 1120                 1125             


Gln Tyr  Leu Phe Ala Phe Glu  Cys Lys Ile Glu Arg  Gly Glu Glu 
    1130                 1135                 1140             


Pro Pro  Pro Glu Val Phe Ser  Thr Gly Asp Thr Lys  Lys Gln Pro 
    1145                 1150                 1155             


Lys Leu  Gln Pro Pro Ser Pro  Ala Asn Ser Gly Ser  Leu Gln Gly 
    1160                 1165                 1170             


Pro Gln  Thr Pro Gln Ser Thr  Gly Ser Asn Ser Met  Ala Glu Val 
    1175                 1180                 1185             


Pro Gly  Asp Leu Lys Pro Pro  Thr Pro Ala Ser Thr  Pro His Gly 
    1190                 1195                 1200             


Gln Met  Thr Pro Met Gln Gly  Gly Arg Ser Ser Thr  Ile Ser Val 
    1205                 1210                 1215             


His Asp  Pro Phe Ser Asp Val  Ser Asp Ser Ser Phe  Pro Lys Arg 
    1220                 1225                 1230             


Asn Ser  Met Thr Pro Asn Ala  Pro Tyr Gln Gln Gly  Met Ser Met 
    1235                 1240                 1245             


Pro Asp  Val Met Gly Arg Met  Pro Tyr Glu Pro Asn  Lys Asp Pro 
    1250                 1255                 1260             


Phe Gly  Gly Met Arg Lys Val  Pro Gly Ser Ser Glu  Pro Phe Met 
    1265                 1270                 1275             


Thr Gln  Gly Gln Met Pro Asn  Ser Ser Met Gln Asp  Met Tyr Asn 
    1280                 1285                 1290             


Gln Ser  Pro Ser Gly Ala Met  Ser Asn Leu Gly Met  Gly Gln Arg 
    1295                 1300                 1305             


Gln Gln  Phe Pro Tyr Gly Ala  Ser Tyr Asp Arg Arg  His Glu Pro 
    1310                 1315                 1320             


Tyr Gly  Gln Gln Tyr Pro Gly  Gln Gly Pro Pro Ser  Gly Gln Pro 
    1325                 1330                 1335             


Pro Tyr  Gly Gly His Gln Pro  Gly Leu Tyr Pro Gln  Gln Pro Asn 
    1340                 1345                 1350             


Tyr Lys  Arg His Met Asp Gly  Met Tyr Gly Pro Pro  Ala Lys Arg 
    1355                 1360                 1365             


His Glu  Gly Asp Met Tyr Asn  Met Gln Tyr Ser Ser  Gln Gln Gln 
    1370                 1375                 1380             


Glu Met  Tyr Asn Gln Tyr Gly  Gly Ser Tyr Ser Gly  Pro Asp Arg 
    1385                 1390                 1395             


Arg Pro  Ile Gln Gly Gln Tyr  Pro Tyr Pro Tyr Ser  Arg Glu Arg 
    1400                 1405                 1410             


Met Gln  Gly Pro Gly Gln Ile  Gln Thr His Gly Ile  Pro Pro Gln 
    1415                 1420                 1425             


Met Met  Gly Gly Pro Leu Gln  Ser Ser Ser Ser Glu  Gly Pro Gln 
    1430                 1435                 1440             


Gln Asn  Met Trp Ala Ala Arg  Asn Asp Met Pro Tyr  Pro Tyr Gln 
    1445                 1450                 1455             


Asn Arg  Gln Gly Pro Gly Gly  Pro Thr Gln Ala Pro  Pro Tyr Pro 
    1460                 1465                 1470             


Gly Met  Asn Arg Thr Asp Asp  Met Met Val Pro Asp  Gln Arg Ile 
    1475                 1480                 1485             


Asn His  Glu Ser Gln Trp Pro  Ser His Val Ser Gln  Arg Gln Pro 
    1490                 1495                 1500             


Tyr Met  Ser Ser Ser Ala Ser  Met Gln Pro Ile Thr  Arg Pro Pro 
    1505                 1510                 1515             


Gln Pro  Ser Tyr Gln Thr Pro  Pro Ser Leu Pro Asn  His Ile Ser 
    1520                 1525                 1530             


Arg Ala  Pro Ser Pro Ala Ser  Phe Gln Arg Ser Leu  Glu Asn Arg 
    1535                 1540                 1545             


Met Ser  Pro Ser Lys Ser Pro  Phe Leu Pro Ser Met  Lys Met Gln 
    1550                 1555                 1560             


Lys Val  Met Pro Thr Val Pro  Thr Ser Gln Val Thr  Gly Pro Pro 
    1565                 1570                 1575             


Pro Gln  Pro Pro Pro Ile Arg  Arg Glu Ile Thr Phe  Pro Pro Gly 
    1580                 1585                 1590             


Ser Val  Glu Ala Ser Gln Pro  Val Leu Lys Gln Arg  Arg Lys Ile 
    1595                 1600                 1605             


Thr Ser  Lys Asp Ile Val Thr  Pro Glu Ala Trp Arg  Val Met Met 
    1610                 1615                 1620             


Ser Leu  Lys Ser Gly Leu Leu  Ala Glu Ser Thr Trp  Ala Leu Asp 
    1625                 1630                 1635             


Thr Ile  Asn Ile Leu Leu Tyr  Asp Asp Ser Thr Val  Ala Thr Phe 
    1640                 1645                 1650             


Asn Leu  Ser Gln Leu Ser Gly  Phe Leu Glu Leu Leu  Val Glu Tyr 
    1655                 1660                 1665             


Phe Arg  Lys Cys Leu Ile Asp  Ile Phe Gly Ile Leu  Met Glu Tyr 
    1670                 1675                 1680             


Glu Val  Gly Asp Pro Ser Gln  Lys Ala Leu Asp His  Asn Ala Ala 
    1685                 1690                 1695             


Arg Lys  Asp Asp Ser Gln Ser  Leu Ala Asp Asp Ser  Gly Lys Glu 
    1700                 1705                 1710             


Glu Glu  Asp Ala Glu Cys Ile  Asp Asp Asp Glu Glu  Asp Glu Glu 
    1715                 1720                 1725             


Asp Glu  Glu Glu Asp Ser Glu  Lys Thr Glu Ser Asp  Glu Lys Ser 
    1730                 1735                 1740             


Ser Ile  Ala Leu Thr Ala Pro  Asp Ala Ala Ala Asp  Pro Lys Glu 
    1745                 1750                 1755             


Lys Pro  Lys Gln Ala Ser Lys  Phe Asp Lys Leu Pro  Ile Lys Ile 
    1760                 1765                 1770             


Val Lys  Lys Asn Asn Leu Phe  Val Val Asp Arg Ser  Asp Lys Leu 
    1775                 1780                 1785             


Gly Arg  Val Gln Glu Phe Asn  Ser Gly Leu Leu His  Trp Gln Leu 
    1790                 1795                 1800             


Gly Gly  Gly Asp Thr Thr Glu  His Ile Gln Thr His  Phe Glu Ser 
    1805                 1810                 1815             


Lys Met  Glu Ile Pro Pro Arg  Arg Arg Pro Pro Pro  Pro Leu Ser 
    1820                 1825                 1830             


Ser Ala  Gly Arg Lys Lys Glu  Gln Glu Gly Lys Gly  Asp Ser Glu 
    1835                 1840                 1845             


Glu Gln  Gln Glu Lys Ser Ile  Ile Ala Thr Ile Asp  Asp Val Leu 
    1850                 1855                 1860             


Ser Ala  Arg Pro Gly Ala Leu  Pro Glu Asp Ala Asn  Pro Gly Pro 
    1865                 1870                 1875             


Gln Thr  Glu Ser Ser Lys Phe  Pro Phe Gly Ile Gln  Gln Ala Lys 
    1880                 1885                 1890             


Ser His  Arg Asn Ile Lys Leu  Leu Glu Asp Glu Pro  Arg Ser Arg 
    1895                 1900                 1905             


Asp Glu  Thr Pro Leu Cys Thr  Ile Ala His Trp Gln  Asp Ser Leu 
    1910                 1915                 1920             


Ala Lys  Arg Cys Ile Cys Val  Ser Asn Ile Val Arg  Ser Leu Ser 
    1925                 1930                 1935             


Phe Val  Pro Gly Asn Asp Ala  Glu Met Ser Lys His  Pro Gly Leu 
    1940                 1945                 1950             


Val Leu  Ile Leu Gly Lys Leu  Ile Leu Leu His His  Glu His Pro 
    1955                 1960                 1965             


Glu Arg  Lys Arg Ala Pro Gln  Thr Tyr Glu Lys Glu  Glu Asp Glu 
    1970                 1975                 1980             


Asp Lys  Gly Val Ala Cys Ser  Lys Asp Glu Trp Trp  Trp Asp Cys 
    1985                 1990                 1995             


Leu Glu  Val Leu Arg Asp Asn  Thr Leu Val Thr Leu  Ala Asn Ile 
    2000                 2005                 2010             


Ser Gly  Gln Leu Asp Leu Ser  Ala Tyr Thr Glu Ser  Ile Cys Leu 
    2015                 2020                 2025             


Pro Ile  Leu Asp Gly Leu Leu  His Trp Met Val Cys  Pro Ser Ala 
    2030                 2035                 2040             


Glu Ala  Gln Asp Pro Phe Pro  Thr Val Gly Pro Asn  Ser Val Leu 
    2045                 2050                 2055             


Ser Pro  Gln Arg Leu Val Leu  Glu Thr Leu Cys Lys  Leu Ser Ile 
    2060                 2065                 2070             


Gln Asp  Asn Asn Val Asp Leu  Ile Leu Ala Thr Pro  Pro Phe Ser 
    2075                 2080                 2085             


Arg Gln  Glu Lys Phe Tyr Ala  Thr Leu Val Arg Tyr  Val Gly Asp 
    2090                 2095                 2100             


Arg Lys  Asn Pro Val Cys Arg  Glu Met Ser Met Ala  Leu Leu Ser 
    2105                 2110                 2115             


Asn Leu  Ala Gln Gly Asp Ala  Leu Ala Ala Arg Ala  Ile Ala Val 
    2120                 2125                 2130             


Gln Lys  Gly Ser Ile Gly Asn  Leu Ile Ser Phe Leu  Glu Asp Gly 
    2135                 2140                 2145             


Val Thr  Met Ala Gln Tyr Gln  Gln Ser Gln His Asn  Leu Met His 
    2150                 2155                 2160             


Met Gln  Pro Pro Pro Leu Glu  Pro Pro Ser Val Asp  Met Met Cys 
    2165                 2170                 2175             


Arg Ala  Ala Lys Ala Leu Leu  Ala Met Ala Arg Val  Asp Glu Asn 
    2180                 2185                 2190             


Arg Ser  Glu Phe Leu Leu His  Glu Gly Arg Leu Leu  Asp Ile Ser 
    2195                 2200                 2205             


Ile Ser  Ala Val Leu Asn Ser  Leu Val Ala Ser Val  Ile Cys Asp 
    2210                 2215                 2220             


Val Leu  Phe Gln Ile Gly Gln  Leu 
    2225                 2230     


<210>  1881
<211>  8126
<212>  DNA
<213>  Homosapiens

<400>  1881
cggccgccgc cggcacccac agcgccaaga gcggcggctc cgaggcggct ctcaaggagg     60

gtggaagcgc cgccgcgctg tcctcctcct cctcctcctc cgcggcggca gcggcggcat    120

cctcttcctc ctcgtcgggc ccgggctcgg ccatggagac ggggctgctc cccaaccaca    180

aactgaaaac cgttggcgaa gcccccgccg cgccgcccca ccagcagcac caccaccacc    240

accatgccca ccaccaccac caccatgccc accacctcca ccaccaccac gcactacagc    300

agcagctaaa ccagttccag cagcagcagc agcagcagca acagcagcag cagcagcagc    360

agcaacagca acatcccatt tccaacaaca acagcttggg cggcgcgggc ggcggcgcgc    420

ctcagcccgg ccccgacatg gagcagccgc aacatggagg cgccaaggac agtgctgcgg    480

gcggccaggc cgaccccccg ggcccgccgc tgctgagcaa gccgggcgac gaggacgacg    540

cgccgcccaa gatgggggag ccggcgggcg gccgctacga gcacccgggc ttgggcgccc    600

tgggcacgca gcagccgccg gtcgccgtgc ccgggggcgg cggcggcccg gcggccgtcc    660

cggagtttaa taattactat ggcagcgctg cccctgcgag cggcggcccc ggcggccgcg    720

ctgggccttg ctttgatcaa catggcggac aacaaagccc cgggatgggg atgatgcact    780

ccgcctccgc cgccgccgcc ggggcccccg gcagcatgga ccccctgcag aactcccacg    840

aagggtaccc caacagccag tgcaaccatt atccgggcta cagccggccc ggcgcgggcg    900

gcggcggcgg cggcggcggc ggaggaggag gaggcagcgg aggaggagga ggaggaggag    960

gagcaggagc aggaggagca ggagcgggag ctgtggcggc ggcggccgcg gcggcggcgg   1020

cagcagcagg aggcggcggc ggcggcggct atgggggctc gtccgcgggg tacggggtgc   1080

tgagctcccc ccggcagcag ggcggcggca tgatgatggg ccccgggggc ggcggggccg   1140

cgagcctcag caaggcggcc gccggctcgg cggcgggggg cttccagcgc ttcgccggcc   1200

agaaccagca cccgtcgggg gccaccccga ccctcaatca gctgctcacc tcgcccagcc   1260

ccatgatgcg gagctacggc ggcagctacc ccgagtacag cagccccagc gcgccgccgc   1320

cgccgccgtc gcagccccag tcccaggcgg cggcggcggg ggcggcggcg ggcggccagc   1380

aggcggccgc gggcatgggc ttgggcaagg acatgggcgc ccagtacgcc gctgccagcc   1440

cggcctgggc ggccgcgcaa caaaggagtc acccggcgat gagccccggc acccccggac   1500

cgaccatggg cagatcccag ggcagcccaa tggatccaat ggtgatgaag agacctcagt   1560

tgtatggcat gggcagtaac cctcattctc agcctcagca gagcagtccg tacccaggag   1620

gttcctatgg ccctccaggc ccacagcggt atccaattgg catccagggt cggactcccg   1680

gggccatggc cggaatgcag taccctcagc agcaggactc tggagatgcc acatggaaag   1740

aaacattctg gttgatgcca cctcagtatg gacagcaagg tgtgagtggt tactgccagc   1800

agggccaaca gccatattac agccagcagc cgcagccccc gcacctccca ccccaggcgc   1860

agtatctgcc gtcccagtcc cagcagaggt accagccgca gcaggacatg tctcaggaag   1920

gctatggaac tagatctcaa cctcctctgg cccccggaaa acctaaccat gaagacttga   1980

acttaataca gcaagaaaga ccatcaagtt taccagatct gtctggctcc attgatgacc   2040

tccccacggg aacggaagca actttgagct cagcagtcag tgcatccggg tccacgagca   2100

gccaagggga tcagagcaac ccggcgcagt cgcctttctc cccacatgcg tcccctcatc   2160

tctccagcat cccggggggc ccatctccct ctcctgttgg ctctcctgta ggaagcaacc   2220

agtctcgatc tggcccaatc tctcctgcaa gtatcccagg tagtcagatg cctccgcagc   2280

cacccgggag ccagtcagaa tccagttccc atcccgcctt gagccagtca ccaatgccac   2340

aggaaagagg ttttatggca ggcacacaaa gaaaccctca gatggctcag tatggacctc   2400

aacagacagg accatccatg tcgcctcatc cttctcctgg gggccagatg catgctggaa   2460

tcagtagctt tcagcagagt aactcaagtg ggacttacgg tccacagatg agccagtatg   2520

gaccacaagg taactactcc agacccccag cgtatagtgg ggtgcccagt gcaagctaca   2580

gcggcccagg gcccggtatg ggtatcagtg ccaacaacca gatgcatgga caagggccaa   2640

gccagccatg tggtgctgtg cccctgggac gaatgccatc agctgggatg cagaacagac   2700

catttcctgg aaatatgagc agcatgaccc ccagttctcc tggcatgtct cagcagggag   2760

ggccaggaat ggggccgcca atgccaactg tgaaccgtaa ggcacaggag gcagccgcag   2820

cagtgatgca ggctgctgcg aactcagcac aaagcaggca aggcagtttc cccggcatga   2880

accagagtgg acttatggct tccagctctc cctacagcca gcccatgaac aacagctcta   2940

gcctgatgaa cacgcaggcg ccgccctaca gcatggcgcc cgccatggtg aacagctcgg   3000

cagcatctgt gggtcttgca gatatgatgt ctcctggtga atccaaactg cccctgcctc   3060

tcaaagcaga cggcaaagaa gaaggcactc cacagcccga gagcaagtca aagaagtcca   3120

gctcctccac cactactggg gagaagatca cgaaggtgta cgagctgggg aatgagccag   3180

agagaaagct ctgggtcgac cgatacctca ccttcatgga agagagaggc tctcctgtct   3240

caagtctgcc tgccgtgggc aagaagcccc tggacctgtt ccgactctac gtctgcgtca   3300

aagagatcgg gggtttggcc caggttaata aaaacaagaa gtggcgtgag ctggcaacca   3360

acctaaacgt tggcacctca agcagtgcag cgagctccct gaaaaagcag tatattcagt   3420

acctgtttgc ctttgagtgc aagatcgaac gtggggagga gcccccgccg gaagtcttca   3480

gcaccgggga caccaaaaag cagcccaagc tccagccgcc atctcctgct aactcgggat   3540

ccttgcaagg cccacagacc ccccagtcaa ctggcagcaa ttccatggca gaggttccag   3600

gtgacctgaa gccacctacc ccagcctcca cccctcacgg ccagatgact ccaatgcaag   3660

gtggaagaag cagtacaatc agtgtgcacg acccattctc agatgtgagt gattcatcct   3720

tcccgaaacg gaactccatg actccaaacg ccccctacca gcagggcatg agcatgcccg   3780

atgtgatggg caggatgccc tatgagccca acaaggaccc ctttggggga atgagaaaag   3840

tgcctggaag cagcgagccc tttatgacgc aaggacagat gcccaacagc agcatgcagg   3900

acatgtacaa ccaaagtccc tccggagcaa tgtctaacct gggcatgggg cagcgccagc   3960

agtttcccta tggagccagt tacgaccgaa ggcatgaacc ttatgggcag cagtatccag   4020

gccaaggccc tccctcggga cagccgccgt atggagggca ccagcccggc ctgtacccac   4080

agcagccgaa ttacaaacgc catatggacg gcatgtacgg gcccccagcc aagcgccacg   4140

agggcgacat gtacaacatg cagtacagca gccagcagca ggagatgtac aaccagtatg   4200

gaggctccta ctcgggcccg gaccgcaggc ccatccaggg ccagtacccg tatccctaca   4260

gcagggagag gatgcagggc ccggggcaga tccagacaca cggaatcccg cctcagatga   4320

tgggcggccc gctgcagtcg tcctccagtg aggggcctca gcagaatatg tgggcagcac   4380

gcaatgatat gccttatccc taccagaaca ggcagggccc tggcggccct acacaggcgc   4440

ccccttaccc aggcatgaac cgcacagacg atatgatggt acccgatcag aggataaatc   4500

atgagagcca gtggccttct cacgtcagcc agcgtcagcc ttatatgtcg tcctcagcct   4560

ccatgcagcc catcacacgc ccaccacagc cgtcctacca gacgccaccg tcactgccaa   4620

atcacatctc cagggcgccc agcccagcgt ccttccagcg ctccctggag aaccgcatgt   4680

ctccaagcaa gtctcctttt ctgccgtcta tgaagatgca gaaggtcatg cccacggtcc   4740

ccacatccca ggtcaccggg ccaccacccc aaccaccccc aatcagaagg gagatcacct   4800

ttcctcctgg ctcagtagaa gcatcacaac cagtcttgaa acaaaggcga aagattacct   4860

ccaaagatat cgttactcct gaggcgtggc gtgtgatgat gtcccttaaa tcaggtcttt   4920

tggctgagag tacgtgggct ttggacacta ttaatattct tctgtatgat gacagcactg   4980

ttgctacttt caatctctcc cagttgtctg gatttctcga acttttagtc gagtacttta   5040

gaaaatgcct gattgacatt tttggaattc ttatggaata tgaagtggga gaccccagcc   5100

aaaaagcact tgatcacaac gcagcaagga aggatgacag ccagtccttg gcagacgatt   5160

ctgggaaaga ggaggaagat gctgaatgta ttgatgacga cgaggaagac gaggaggatg   5220

aggaggaaga cagcgagaag acagaaagcg atgaaaagag cagcatcgct ctgactgccc   5280

cggacgccgc tgcagaccca aaggagaagc ccaagcaagc cagtaagttc gacaagctgc   5340

caataaagat agtcaaaaag aacaacctgt ttgttgttga ccgatctgac aagttggggc   5400

gtgtgcagga gttcaatagt ggccttctgc actggcagct cggcgggggt gacaccaccg   5460

agcacattca gactcacttt gagagcaaga tggaaattcc tcctcgcagg cgcccacctc   5520

cccccttaag ctccgcaggt agaaagaaag agcaagaagg caaaggcgac tctgaagagc   5580

agcaagagaa aagcatcata gcaaccatcg atgacgtcct ctctgctcgg ccaggggcat   5640

tgcctgaaga cgcaaaccct gggccccaga ccgaaagcag taagtttccc tttggtatcc   5700

agcaagccaa aagtcaccgg aacatcaagc tgctggagga cgagcccagg agccgagacg   5760

agactcctct gtgtaccatc gcgcactggc aggactcgct ggctaagcga tgcatctgtg   5820

tgtccaatat tgtccgtagc ttgtcattcg tgcctggcaa tgatgccgaa atgtccaaac   5880

atccaggcct ggtgctgatc ctggggaagc tgattcttct tcaccacgag catccagaga   5940

gaaagcgagc accgcagacc tatgagaaag aggaggatga ggacaagggg gtggcctgca   6000

gcaaagatga gtggtggtgg gactgcctcg aggtcttgag ggataacacg ttggtcacgt   6060

tggccaacat ttccgggcag ctagacttgt ctgcttacac ggaaagcatc tgcttgccaa   6120

ttttggatgg cttgctgcac tggatggtgt gcccgtctgc agaggcacaa gatccctttc   6180

caactgtggg acccaactcg gtcctgtcgc ctcagagact tgtgctggag accctctgta   6240

aactcagtat ccaggacaat aatgtggacc tgatcttggc cactcctcca tttagtcgtc   6300

aggagaaatt ctatgctaca ttagttaggt acgttgggga tcgcaaaaac ccagtctgtc   6360

gagaaatgtc catggcgctt ttatcgaacc ttgcccaagg ggacgcacta gcagcaaggg   6420

ccatagctgt gcagaaagga agcattggaa acttgataag cttcctagag gatggggtca   6480

cgatggccca gtaccagcag agccagcaca acctcatgca catgcagccc ccgcccctgg   6540

aaccacctag cgtagacatg atgtgcaggg cggccaaggc tttgctagcc atggccagag   6600

tggacgaaaa ccgctcggaa ttccttttgc acgagggccg gttgctggat atctcgatat   6660

cagctgtcct gaactctctg gttgcatctg tcatctgtga tgtactgttt cagattgggc   6720

agttatgaca taagtgagaa ggcaagcatg tgtgagtgaa gattagaggg tcacatataa   6780

ctggctgttt tctgttcttg tttatccagc gtaggaagaa ggaaaagaaa atctttgctc   6840

ctctgcccca ttcactattt accaattggg aattaaagaa ataattaatt tgaacagtta   6900

tgaaattaat atttgctgtc tgtgtgtata agtacatcct ttggggtttt ttttttctct   6960

tttttttaac caaagttgct gtctagtgca ttcaaaggtc actttttgtt cttcacagat   7020

ctttttaatg ttctttccca tgttgtattg catttttggg ggaagcaaat tgactttaaa   7080

gaaaaaagtt gtggcaaaag atgctaagat gcgaaaattt caccacactg agtcaaaaag   7140

gtgaaaaatt atccatttcc tatgcgtttt actcctcaga gaatgaaaaa aactgcatcc   7200

catcacccaa agttctgtgc aatagaaatt tctacagata caggtatagg ggctcaagga   7260

ggtatgtcgg tcagtagtca aaactatgaa atgatactgg tttctccaca ggaatatggt   7320

tccattaggc tgggagcaaa aacaatgttt tttaagattg agaatacata cctgacaacg   7380

atccggaaac tgctcctcac cactcccgtc atgcctgctg tcggcgtttg accttccacg   7440

tgacagttct tcacaattcc tttcatcatt ttttaaatat tttttttact gcctatgggc   7500

tgtgatgtat atagaagttg tacattaaac ataccctcat ttttttcttt tctttttttt   7560

tttttttttt agtacaaagt tttagtttct ttttcatgat gtggtaacta cgaagtgatg   7620

gtagatttaa ataatttttt atttttattt tatatatttt ttcattaggg ccatatctcc   7680

aaaaaaagaa agaaaaaata caaaaaacaa aaacaaaaaa aaaagagggt aatgtacaag   7740

tttctgtatg tataaagtca tgctcgattt caggagagca gctgatcaca atttgcttca   7800

tgaatcaagg tgtggaaatg gttatatatg gattgattta gaaaatggtt accagtacag   7860

tcaaaaaaga gaaaatgaaa aaaatacaac taaaaggaag aaacacaact tcaaagattt   7920

ttcagtgatg agaatccaca tttgtatttc aagataatgt agtttaaaaa aaaaaaaaag   7980

aaaaaaactt gatgtaaatt cctccttttc ctctggctta atgaatatca tttattcagt   8040

ataaaatctt tatatgttcc acatgttaag aataaatgta cattaaatct tgttaagcac   8100

tgtgaaaaaa aaaaaaaaaa aaaaaa                                        8126


<210>  1882
<211>  2191
<212>  PRT
<213>  Homosapiens

<400>  1882

Met Glu Thr Gly Leu Leu Pro Asn His Lys Leu Lys Thr Val Gly Glu 
1               5                   10                  15      


Ala Pro Ala Ala Pro Pro His Gln Gln His His His His His His Ala 
            20                  25                  30          


His His His His His His Ala His His Leu His His His His Ala Leu 
        35                  40                  45              


Gln Gln Gln Leu Asn Gln Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln His Pro Ile Ser Asn Asn Asn 
65                  70                  75                  80  


Ser Leu Gly Gly Ala Gly Gly Gly Ala Pro Gln Pro Gly Pro Asp Met 
                85                  90                  95      


Glu Gln Pro Gln His Gly Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln 
            100                 105                 110         


Ala Asp Pro Pro Gly Pro Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp 
        115                 120                 125             


Asp Ala Pro Pro Lys Met Gly Glu Pro Ala Gly Gly Arg Tyr Glu His 
    130                 135                 140                 


Pro Gly Leu Gly Ala Leu Gly Thr Gln Gln Pro Pro Val Ala Val Pro 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Pro Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr 
                165                 170                 175     


Gly Ser Ala Ala Pro Ala Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro 
            180                 185                 190         


Cys Phe Asp Gln His Gly Gly Gln Gln Ser Pro Gly Met Gly Met Met 
        195                 200                 205             


His Ser Ala Ser Ala Ala Ala Ala Gly Ala Pro Gly Ser Met Asp Pro 
    210                 215                 220                 


Leu Gln Asn Ser His Glu Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr 
225                 230                 235                 240 


Pro Gly Tyr Ser Arg Pro Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly 
            260                 265                 270         


Ala Gly Gly Ala Gly Ala Gly Ala Val Ala Ala Ala Ala Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser 
    290                 295                 300                 


Ala Gly Tyr Gly Val Leu Ser Ser Pro Arg Gln Gln Gly Gly Gly Met 
305                 310                 315                 320 


Met Met Gly Pro Gly Gly Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala 
                325                 330                 335     


Ala Gly Ser Ala Ala Gly Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln 
            340                 345                 350         


His Pro Ser Gly Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro 
        355                 360                 365             


Ser Pro Met Met Arg Ser Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser 
    370                 375                 380                 


Pro Ser Ala Pro Pro Pro Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala 
385                 390                 395                 400 


Ala Ala Gly Ala Ala Ala Gly Gly Gln Gln Ala Ala Ala Gly Met Gly 
                405                 410                 415     


Leu Gly Lys Asp Met Gly Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp 
            420                 425                 430         


Ala Ala Ala Gln Gln Arg Ser His Pro Ala Met Ser Pro Gly Thr Pro 
        435                 440                 445             


Gly Pro Thr Met Gly Arg Ser Gln Gly Ser Pro Met Asp Pro Met Val 
    450                 455                 460                 


Met Lys Arg Pro Gln Leu Tyr Gly Met Gly Ser Asn Pro His Ser Gln 
465                 470                 475                 480 


Pro Gln Gln Ser Ser Pro Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly 
                485                 490                 495     


Pro Gln Arg Tyr Pro Ile Gly Ile Gln Gly Arg Thr Pro Gly Ala Met 
            500                 505                 510         


Ala Gly Met Gln Tyr Pro Gln Gln Gln Asp Ser Gly Asp Ala Thr Trp 
        515                 520                 525             


Lys Glu Thr Phe Trp Leu Met Pro Pro Gln Tyr Gly Gln Gln Gly Val 
    530                 535                 540                 


Ser Gly Tyr Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro 
545                 550                 555                 560 


Gln Pro Pro His Leu Pro Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser 
                565                 570                 575     


Gln Gln Arg Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly 
            580                 585                 590         


Thr Arg Ser Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn His Glu Asp 
        595                 600                 605             


Leu Asn Leu Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser 
    610                 615                 620                 


Gly Ser Ile Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr Leu Ser Ser 
625                 630                 635                 640 


Ala Val Ser Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp Gln Ser Asn 
                645                 650                 655     


Pro Ala Gln Ser Pro Phe Ser Pro His Ala Ser Pro His Leu Ser Ser 
            660                 665                 670         


Ile Pro Gly Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Val Gly Ser 
        675                 680                 685             


Asn Gln Ser Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser 
    690                 695                 700                 


Gln Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His 
705                 710                 715                 720 


Pro Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Ala 
                725                 730                 735     


Gly Thr Gln Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Thr 
            740                 745                 750         


Gly Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala 
        755                 760                 765             


Gly Ile Ser Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr Tyr Gly Pro 
    770                 775                 780                 


Gln Met Ser Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala 
785                 790                 795                 800 


Tyr Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met 
                805                 810                 815     


Gly Ile Ser Ala Asn Asn Gln Met His Gly Gln Gly Pro Ser Gln Pro 
            820                 825                 830         


Cys Gly Ala Val Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn 
        835                 840                 845             


Arg Pro Phe Pro Gly Asn Met Ser Ser Met Thr Pro Ser Ser Pro Gly 
    850                 855                 860                 


Met Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Thr Val 
865                 870                 875                 880 


Asn Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala 
                885                 890                 895     


Asn Ser Ala Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser 
            900                 905                 910         


Gly Leu Met Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser 
        915                 920                 925             


Ser Ser Leu Met Asn Thr Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala 
    930                 935                 940                 


Met Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala Asp Met Met Ser 
945                 950                 955                 960 


Pro Gly Glu Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp Gly Lys Glu 
                965                 970                 975     


Glu Gly Thr Pro Gln Pro Glu Ser Lys Ser Lys Lys Ser Ser Ser Ser 
            980                 985                 990         


Thr Thr Thr Gly Glu Lys Ile Thr  Lys Val Tyr Glu Leu  Gly Asn Glu 
        995                 1000                 1005             


Pro Glu  Arg Lys Leu Trp Val  Asp Arg Tyr Leu Thr  Phe Met Glu 
    1010                 1015                 1020             


Glu Arg  Gly Ser Pro Val Ser  Ser Leu Pro Ala Val  Gly Lys Lys 
    1025                 1030                 1035             


Pro Leu  Asp Leu Phe Arg Leu  Tyr Val Cys Val Lys  Glu Ile Gly 
    1040                 1045                 1050             


Gly Leu  Ala Gln Val Asn Lys  Asn Lys Lys Trp Arg  Glu Leu Ala 
    1055                 1060                 1065             


Thr Asn  Leu Asn Val Gly Thr  Ser Ser Ser Ala Ala  Ser Ser Leu 
    1070                 1075                 1080             


Lys Lys  Gln Tyr Ile Gln Tyr  Leu Phe Ala Phe Glu  Cys Lys Ile 
    1085                 1090                 1095             


Glu Arg  Gly Glu Glu Pro Pro  Pro Glu Val Phe Ser  Thr Gly Asp 
    1100                 1105                 1110             


Thr Lys  Lys Gln Pro Lys Leu  Gln Pro Pro Ser Pro  Ala Asn Ser 
    1115                 1120                 1125             


Gly Ser  Leu Gln Gly Pro Gln  Thr Pro Gln Ser Thr  Gly Ser Asn 
    1130                 1135                 1140             


Ser Met  Ala Glu Val Pro Gly  Asp Leu Lys Pro Pro  Thr Pro Ala 
    1145                 1150                 1155             


Ser Thr  Pro His Gly Gln Met  Thr Pro Met Gln Gly  Gly Arg Ser 
    1160                 1165                 1170             


Ser Thr  Ile Ser Val His Asp  Pro Phe Ser Asp Val  Ser Asp Ser 
    1175                 1180                 1185             


Ser Phe  Pro Lys Arg Asn Ser  Met Thr Pro Asn Ala  Pro Tyr Gln 
    1190                 1195                 1200             


Gln Gly  Met Ser Met Pro Asp  Val Met Gly Arg Met  Pro Tyr Glu 
    1205                 1210                 1215             


Pro Asn  Lys Asp Pro Phe Gly  Gly Met Arg Lys Val  Pro Gly Ser 
    1220                 1225                 1230             


Ser Glu  Pro Phe Met Thr Gln  Gly Gln Met Pro Asn  Ser Ser Met 
    1235                 1240                 1245             


Gln Asp  Met Tyr Asn Gln Ser  Pro Ser Gly Ala Met  Ser Asn Leu 
    1250                 1255                 1260             


Gly Met  Gly Gln Arg Gln Gln  Phe Pro Tyr Gly Ala  Ser Tyr Asp 
    1265                 1270                 1275             


Arg Arg  His Glu Pro Tyr Gly  Gln Gln Tyr Pro Gly  Gln Gly Pro 
    1280                 1285                 1290             


Pro Ser  Gly Gln Pro Pro Tyr  Gly Gly His Gln Pro  Gly Leu Tyr 
    1295                 1300                 1305             


Pro Gln  Gln Pro Asn Tyr Lys  Arg His Met Asp Gly  Met Tyr Gly 
    1310                 1315                 1320             


Pro Pro  Ala Lys Arg His Glu  Gly Asp Met Tyr Asn  Met Gln Tyr 
    1325                 1330                 1335             


Ser Ser  Gln Gln Gln Glu Met  Tyr Asn Gln Tyr Gly  Gly Ser Tyr 
    1340                 1345                 1350             


Ser Gly  Pro Asp Arg Arg Pro  Ile Gln Gly Gln Tyr  Pro Tyr Pro 
    1355                 1360                 1365             


Tyr Ser  Arg Glu Arg Met Gln  Gly Pro Gly Gln Ile  Gln Thr His 
    1370                 1375                 1380             


Gly Ile  Pro Pro Gln Met Met  Gly Gly Pro Leu Gln  Ser Ser Ser 
    1385                 1390                 1395             


Ser Glu  Gly Pro Gln Gln Asn  Met Trp Ala Ala Arg  Asn Asp Met 
    1400                 1405                 1410             


Pro Tyr  Pro Tyr Gln Asn Arg  Gln Gly Pro Gly Gly  Pro Thr Gln 
    1415                 1420                 1425             


Ala Pro  Pro Tyr Pro Gly Met  Asn Arg Thr Asp Asp  Met Met Val 
    1430                 1435                 1440             


Pro Asp  Gln Arg Ile Asn His  Glu Ser Gln Trp Pro  Ser His Val 
    1445                 1450                 1455             


Ser Gln  Arg Gln Pro Tyr Met  Ser Ser Ser Ala Ser  Met Gln Pro 
    1460                 1465                 1470             


Ile Thr  Arg Pro Pro Gln Pro  Ser Tyr Gln Thr Pro  Pro Ser Leu 
    1475                 1480                 1485             


Pro Asn  His Ile Ser Arg Ala  Pro Ser Pro Ala Ser  Phe Gln Arg 
    1490                 1495                 1500             


Ser Leu  Glu Asn Arg Met Ser  Pro Ser Lys Ser Pro  Phe Leu Pro 
    1505                 1510                 1515             


Ser Met  Lys Met Gln Lys Val  Met Pro Thr Val Pro  Thr Ser Gln 
    1520                 1525                 1530             


Val Thr  Gly Pro Pro Pro Gln  Pro Pro Pro Ile Arg  Arg Glu Ile 
    1535                 1540                 1545             


Thr Phe  Pro Pro Gly Ser Val  Glu Ala Ser Gln Pro  Val Leu Lys 
    1550                 1555                 1560             


Gln Arg  Arg Lys Ile Thr Ser  Lys Asp Ile Val Thr  Pro Glu Ala 
    1565                 1570                 1575             


Trp Arg  Val Met Met Ser Leu  Lys Ser Gly Leu Leu  Ala Glu Ser 
    1580                 1585                 1590             


Thr Trp  Ala Leu Asp Thr Ile  Asn Ile Leu Leu Tyr  Asp Asp Ser 
    1595                 1600                 1605             


Thr Val  Ala Thr Phe Asn Leu  Ser Gln Leu Ser Gly  Phe Leu Glu 
    1610                 1615                 1620             


Leu Leu  Val Glu Tyr Phe Arg  Lys Cys Leu Ile Asp  Ile Phe Gly 
    1625                 1630                 1635             


Ile Leu  Met Glu Tyr Glu Val  Gly Asp Pro Ser Gln  Lys Ala Leu 
    1640                 1645                 1650             


Asp His  Asn Ala Ala Arg Lys  Asp Asp Ser Gln Ser  Leu Ala Asp 
    1655                 1660                 1665             


Asp Ser  Gly Lys Glu Glu Glu  Asp Ala Glu Cys Ile  Asp Asp Asp 
    1670                 1675                 1680             


Glu Glu  Asp Glu Glu Asp Glu  Glu Glu Asp Ser Glu  Lys Thr Glu 
    1685                 1690                 1695             


Ser Asp  Glu Lys Ser Ser Ile  Ala Leu Thr Ala Pro  Asp Ala Ala 
    1700                 1705                 1710             


Ala Asp  Pro Lys Glu Lys Pro  Lys Gln Ala Ser Lys  Phe Asp Lys 
    1715                 1720                 1725             


Leu Pro  Ile Lys Ile Val Lys  Lys Asn Asn Leu Phe  Val Val Asp 
    1730                 1735                 1740             


Arg Ser  Asp Lys Leu Gly Arg  Val Gln Glu Phe Asn  Ser Gly Leu 
    1745                 1750                 1755             


Leu His  Trp Gln Leu Gly Gly  Gly Asp Thr Thr Glu  His Ile Gln 
    1760                 1765                 1770             


Thr His  Phe Glu Ser Lys Met  Glu Ile Pro Pro Arg  Arg Arg Pro 
    1775                 1780                 1785             


Pro Pro  Pro Leu Ser Ser Ala  Gly Arg Lys Lys Glu  Gln Glu Gly 
    1790                 1795                 1800             


Lys Gly  Asp Ser Glu Glu Gln  Gln Glu Lys Ser Ile  Ile Ala Thr 
    1805                 1810                 1815             


Ile Asp  Asp Val Leu Ser Ala  Arg Pro Gly Ala Leu  Pro Glu Asp 
    1820                 1825                 1830             


Ala Asn  Pro Gly Pro Gln Thr  Glu Ser Ser Lys Phe  Pro Phe Gly 
    1835                 1840                 1845             


Ile Gln  Gln Ala Lys Ser His  Arg Asn Ile Lys Leu  Leu Glu Asp 
    1850                 1855                 1860             


Glu Pro  Arg Ser Arg Asp Glu  Thr Pro Leu Cys Thr  Ile Ala His 
    1865                 1870                 1875             


Trp Gln  Asp Ser Leu Ala Lys  Arg Cys Ile Cys Val  Ser Asn Ile 
    1880                 1885                 1890             


Val Arg  Ser Leu Ser Phe Val  Pro Gly Asn Asp Ala  Glu Met Ser 
    1895                 1900                 1905             


Lys His  Pro Gly Leu Val Leu  Ile Leu Gly Lys Leu  Ile Leu Leu 
    1910                 1915                 1920             


His His  Glu His Pro Glu Arg  Lys Arg Ala Pro Gln  Thr Tyr Glu 
    1925                 1930                 1935             


Lys Glu  Glu Asp Glu Asp Lys  Gly Val Ala Cys Ser  Lys Asp Glu 
    1940                 1945                 1950             


Trp Trp  Trp Asp Cys Leu Glu  Val Leu Arg Asp Asn  Thr Leu Val 
    1955                 1960                 1965             


Thr Leu  Ala Asn Ile Ser Gly  Gln Leu Asp Leu Ser  Ala Tyr Thr 
    1970                 1975                 1980             


Glu Ser  Ile Cys Leu Pro Ile  Leu Asp Gly Leu Leu  His Trp Met 
    1985                 1990                 1995             


Val Cys  Pro Ser Ala Glu Ala  Gln Asp Pro Phe Pro  Thr Val Gly 
    2000                 2005                 2010             


Pro Asn  Ser Val Leu Ser Pro  Gln Arg Leu Val Leu  Glu Thr Leu 
    2015                 2020                 2025             


Cys Lys  Leu Ser Ile Gln Asp  Asn Asn Val Asp Leu  Ile Leu Ala 
    2030                 2035                 2040             


Thr Pro  Pro Phe Ser Arg Gln  Glu Lys Phe Tyr Ala  Thr Leu Val 
    2045                 2050                 2055             


Arg Tyr  Val Gly Asp Arg Lys  Asn Pro Val Cys Arg  Glu Met Ser 
    2060                 2065                 2070             


Met Ala  Leu Leu Ser Asn Leu  Ala Gln Gly Asp Ala  Leu Ala Ala 
    2075                 2080                 2085             


Arg Ala  Ile Ala Val Gln Lys  Gly Ser Ile Gly Asn  Leu Ile Ser 
    2090                 2095                 2100             


Phe Leu  Glu Asp Gly Val Thr  Met Ala Gln Tyr Gln  Gln Ser Gln 
    2105                 2110                 2115             


His Asn  Leu Met His Met Gln  Pro Pro Pro Leu Glu  Pro Pro Ser 
    2120                 2125                 2130             


Val Asp  Met Met Cys Arg Ala  Ala Lys Ala Leu Leu  Ala Met Ala 
    2135                 2140                 2145             


Arg Val  Asp Glu Asn Arg Ser  Glu Phe Leu Leu His  Glu Gly Arg 
    2150                 2155                 2160             


Leu Leu  Asp Ile Ser Ile Ser  Ala Val Leu Asn Ser  Leu Val Ala 
    2165                 2170                 2175             


Ser Val  Ile Cys Asp Val Leu  Phe Gln Ile Gly Gln  Leu 
    2180                 2185                 2190     


<210>  1883
<211>  8087
<212>  DNA
<213>  Homosapiens

<400>  1883
cggccgccgc cggcacccac agcgccaaga gcggcggctc cgaggcggct ctcaaggagg     60

gtggaagcgc cgccgcgctg tcctcctcct cctcctcctc cgcggcggca gcggcggcat    120

cctcttcctc ctcgtcgggc ccgggctcgg ccatggagac ggggctgctc cccaaccaca    180

aactgaaaac cgttggcgaa gcccccgccg cgccgcccca ccagcagcac caccaccacc    240

accatgccca ccaccaccac caccatgccc accacctcca ccaccaccac gcactacagc    300

agcagctaaa ccagttccag cagcagcagc agcagcagca acagcagcag cagcagcagc    360

agcaacagca acatcccatt tccaacaaca acagcttggg cggcgcgggc ggcggcgcgc    420

ctcagcccgg ccccgacatg gagcagccgc aacatggagg cgccaaggac agtgctgcgg    480

gcggccaggc cgaccccccg ggcccgccgc tgctgagcaa gccgggcgac gaggacgacg    540

cgccgcccaa gatgggggag ccggcgggcg gccgctacga gcacccgggc ttgggcgccc    600

tgggcacgca gcagccgccg gtcgccgtgc ccgggggcgg cggcggcccg gcggccgtcc    660

cggagtttaa taattactat ggcagcgctg cccctgcgag cggcggcccc ggcggccgcg    720

ctgggccttg ctttgatcaa catggcggac aacaaagccc cgggatgggg atgatgcact    780

ccgcctccgc cgccgccgcc ggggcccccg gcagcatgga ccccctgcag aactcccacg    840

aagggtaccc caacagccag tgcaaccatt atccgggcta cagccggccc ggcgcgggcg    900

gcggcggcgg cggcggcggc ggaggaggag gaggcagcgg aggaggagga ggaggaggag    960

gagcaggagc aggaggagca ggagcgggag ctgtggcggc ggcggccgcg gcggcggcgg   1020

cagcagcagg aggcggcggc ggcggcggct atgggggctc gtccgcgggg tacggggtgc   1080

tgagctcccc ccggcagcag ggcggcggca tgatgatggg ccccgggggc ggcggggccg   1140

cgagcctcag caaggcggcc gccggctcgg cggcgggggg cttccagcgc ttcgccggcc   1200

agaaccagca cccgtcgggg gccaccccga ccctcaatca gctgctcacc tcgcccagcc   1260

ccatgatgcg gagctacggc ggcagctacc ccgagtacag cagccccagc gcgccgccgc   1320

cgccgccgtc gcagccccag tcccaggcgg cggcggcggg ggcggcggcg ggcggccagc   1380

aggcggccgc gggcatgggc ttgggcaagg acatgggcgc ccagtacgcc gctgccagcc   1440

cggcctgggc ggccgcgcaa caaaggagtc acccggcgat gagccccggc acccccggac   1500

cgaccatggg cagatcccag ggcagcccaa tggatccaat ggtgatgaag agacctcagt   1560

tgtatggcat gggcagtaac cctcattctc agcctcagca gagcagtccg tacccaggag   1620

gttcctatgg ccctccaggc ccacagcggt atccaattgg catccagggt cggactcccg   1680

gggccatggc cggaatgcag taccctcagc agcagatgcc acctcagtat ggacagcaag   1740

gtgtgagtgg ttactgccag cagggccaac agccatatta cagccagcag ccgcagcccc   1800

cgcacctccc accccaggcg cagtatctgc cgtcccagtc ccagcagagg taccagccgc   1860

agcaggacat gtctcaggaa ggctatggaa ctagatctca acctcctctg gcccccggaa   1920

aacctaacca tgaagacttg aacttaatac agcaagaaag accatcaagt ttaccagatc   1980

tgtctggctc cattgatgac ctccccacgg gaacggaagc aactttgagc tcagcagtca   2040

gtgcatccgg gtccacgagc agccaagggg atcagagcaa cccggcgcag tcgcctttct   2100

ccccacatgc gtcccctcat ctctccagca tcccgggggg cccatctccc tctcctgttg   2160

gctctcctgt aggaagcaac cagtctcgat ctggcccaat ctctcctgca agtatcccag   2220

gtagtcagat gcctccgcag ccacccggga gccagtcaga atccagttcc catcccgcct   2280

tgagccagtc accaatgcca caggaaagag gttttatggc aggcacacaa agaaaccctc   2340

agatggctca gtatggacct caacagacag gaccatccat gtcgcctcat ccttctcctg   2400

ggggccagat gcatgctgga atcagtagct ttcagcagag taactcaagt gggacttacg   2460

gtccacagat gagccagtat ggaccacaag gtaactactc cagaccccca gcgtatagtg   2520

gggtgcccag tgcaagctac agcggcccag ggcccggtat gggtatcagt gccaacaacc   2580

agatgcatgg acaagggcca agccagccat gtggtgctgt gcccctggga cgaatgccat   2640

cagctgggat gcagaacaga ccatttcctg gaaatatgag cagcatgacc cccagttctc   2700

ctggcatgtc tcagcaggga gggccaggaa tggggccgcc aatgccaact gtgaaccgta   2760

aggcacagga ggcagccgca gcagtgatgc aggctgctgc gaactcagca caaagcaggc   2820

aaggcagttt ccccggcatg aaccagagtg gacttatggc ttccagctct ccctacagcc   2880

agcccatgaa caacagctct agcctgatga acacgcaggc gccgccctac agcatggcgc   2940

ccgccatggt gaacagctcg gcagcatctg tgggtcttgc agatatgatg tctcctggtg   3000

aatccaaact gcccctgcct ctcaaagcag acggcaaaga agaaggcact ccacagcccg   3060

agagcaagtc aaagaagtcc agctcctcca ccactactgg ggagaagatc acgaaggtgt   3120

acgagctggg gaatgagcca gagagaaagc tctgggtcga ccgatacctc accttcatgg   3180

aagagagagg ctctcctgtc tcaagtctgc ctgccgtggg caagaagccc ctggacctgt   3240

tccgactcta cgtctgcgtc aaagagatcg ggggtttggc ccaggttaat aaaaacaaga   3300

agtggcgtga gctggcaacc aacctaaacg ttggcacctc aagcagtgca gcgagctccc   3360

tgaaaaagca gtatattcag tacctgtttg cctttgagtg caagatcgaa cgtggggagg   3420

agcccccgcc ggaagtcttc agcaccgggg acaccaaaaa gcagcccaag ctccagccgc   3480

catctcctgc taactcggga tccttgcaag gcccacagac cccccagtca actggcagca   3540

attccatggc agaggttcca ggtgacctga agccacctac cccagcctcc acccctcacg   3600

gccagatgac tccaatgcaa ggtggaagaa gcagtacaat cagtgtgcac gacccattct   3660

cagatgtgag tgattcatcc ttcccgaaac ggaactccat gactccaaac gccccctacc   3720

agcagggcat gagcatgccc gatgtgatgg gcaggatgcc ctatgagccc aacaaggacc   3780

cctttggggg aatgagaaaa gtgcctggaa gcagcgagcc ctttatgacg caaggacaga   3840

tgcccaacag cagcatgcag gacatgtaca accaaagtcc ctccggagca atgtctaacc   3900

tgggcatggg gcagcgccag cagtttccct atggagccag ttacgaccga aggcatgaac   3960

cttatgggca gcagtatcca ggccaaggcc ctccctcggg acagccgccg tatggagggc   4020

accagcccgg cctgtaccca cagcagccga attacaaacg ccatatggac ggcatgtacg   4080

ggcccccagc caagcgccac gagggcgaca tgtacaacat gcagtacagc agccagcagc   4140

aggagatgta caaccagtat ggaggctcct actcgggccc ggaccgcagg cccatccagg   4200

gccagtaccc gtatccctac agcagggaga ggatgcaggg cccggggcag atccagacac   4260

acggaatccc gcctcagatg atgggcggcc cgctgcagtc gtcctccagt gaggggcctc   4320

agcagaatat gtgggcagca cgcaatgata tgccttatcc ctaccagaac aggcagggcc   4380

ctggcggccc tacacaggcg cccccttacc caggcatgaa ccgcacagac gatatgatgg   4440

tacccgatca gaggataaat catgagagcc agtggccttc tcacgtcagc cagcgtcagc   4500

cttatatgtc gtcctcagcc tccatgcagc ccatcacacg cccaccacag ccgtcctacc   4560

agacgccacc gtcactgcca aatcacatct ccagggcgcc cagcccagcg tccttccagc   4620

gctccctgga gaaccgcatg tctccaagca agtctccttt tctgccgtct atgaagatgc   4680

agaaggtcat gcccacggtc cccacatccc aggtcaccgg gccaccaccc caaccacccc   4740

caatcagaag ggagatcacc tttcctcctg gctcagtaga agcatcacaa ccagtcttga   4800

aacaaaggcg aaagattacc tccaaagata tcgttactcc tgaggcgtgg cgtgtgatga   4860

tgtcccttaa atcaggtctt ttggctgaga gtacgtgggc tttggacact attaatattc   4920

ttctgtatga tgacagcact gttgctactt tcaatctctc ccagttgtct ggatttctcg   4980

aacttttagt cgagtacttt agaaaatgcc tgattgacat ttttggaatt cttatggaat   5040

atgaagtggg agaccccagc caaaaagcac ttgatcacaa cgcagcaagg aaggatgaca   5100

gccagtcctt ggcagacgat tctgggaaag aggaggaaga tgctgaatgt attgatgacg   5160

acgaggaaga cgaggaggat gaggaggaag acagcgagaa gacagaaagc gatgaaaaga   5220

gcagcatcgc tctgactgcc ccggacgccg ctgcagaccc aaaggagaag cccaagcaag   5280

ccagtaagtt cgacaagctg ccaataaaga tagtcaaaaa gaacaacctg tttgttgttg   5340

accgatctga caagttgggg cgtgtgcagg agttcaatag tggccttctg cactggcagc   5400

tcggcggggg tgacaccacc gagcacattc agactcactt tgagagcaag atggaaattc   5460

ctcctcgcag gcgcccacct ccccccttaa gctccgcagg tagaaagaaa gagcaagaag   5520

gcaaaggcga ctctgaagag cagcaagaga aaagcatcat agcaaccatc gatgacgtcc   5580

tctctgctcg gccaggggca ttgcctgaag acgcaaaccc tgggccccag accgaaagca   5640

gtaagtttcc ctttggtatc cagcaagcca aaagtcaccg gaacatcaag ctgctggagg   5700

acgagcccag gagccgagac gagactcctc tgtgtaccat cgcgcactgg caggactcgc   5760

tggctaagcg atgcatctgt gtgtccaata ttgtccgtag cttgtcattc gtgcctggca   5820

atgatgccga aatgtccaaa catccaggcc tggtgctgat cctggggaag ctgattcttc   5880

ttcaccacga gcatccagag agaaagcgag caccgcagac ctatgagaaa gaggaggatg   5940

aggacaaggg ggtggcctgc agcaaagatg agtggtggtg ggactgcctc gaggtcttga   6000

gggataacac gttggtcacg ttggccaaca tttccgggca gctagacttg tctgcttaca   6060

cggaaagcat ctgcttgcca attttggatg gcttgctgca ctggatggtg tgcccgtctg   6120

cagaggcaca agatcccttt ccaactgtgg gacccaactc ggtcctgtcg cctcagagac   6180

ttgtgctgga gaccctctgt aaactcagta tccaggacaa taatgtggac ctgatcttgg   6240

ccactcctcc atttagtcgt caggagaaat tctatgctac attagttagg tacgttgggg   6300

atcgcaaaaa cccagtctgt cgagaaatgt ccatggcgct tttatcgaac cttgcccaag   6360

gggacgcact agcagcaagg gccatagctg tgcagaaagg aagcattgga aacttgataa   6420

gcttcctaga ggatggggtc acgatggccc agtaccagca gagccagcac aacctcatgc   6480

acatgcagcc cccgcccctg gaaccaccta gcgtagacat gatgtgcagg gcggccaagg   6540

ctttgctagc catggccaga gtggacgaaa accgctcgga attccttttg cacgagggcc   6600

ggttgctgga tatctcgata tcagctgtcc tgaactctct ggttgcatct gtcatctgtg   6660

atgtactgtt tcagattggg cagttatgac ataagtgaga aggcaagcat gtgtgagtga   6720

agattagagg gtcacatata actggctgtt ttctgttctt gtttatccag cgtaggaaga   6780

aggaaaagaa aatctttgct cctctgcccc attcactatt taccaattgg gaattaaaga   6840

aataattaat ttgaacagtt atgaaattaa tatttgctgt ctgtgtgtat aagtacatcc   6900

tttggggttt tttttttctc ttttttttaa ccaaagttgc tgtctagtgc attcaaaggt   6960

cactttttgt tcttcacaga tctttttaat gttctttccc atgttgtatt gcatttttgg   7020

gggaagcaaa ttgactttaa agaaaaaagt tgtggcaaaa gatgctaaga tgcgaaaatt   7080

tcaccacact gagtcaaaaa ggtgaaaaat tatccatttc ctatgcgttt tactcctcag   7140

agaatgaaaa aaactgcatc ccatcaccca aagttctgtg caatagaaat ttctacagat   7200

acaggtatag gggctcaagg aggtatgtcg gtcagtagtc aaaactatga aatgatactg   7260

gtttctccac aggaatatgg ttccattagg ctgggagcaa aaacaatgtt ttttaagatt   7320

gagaatacat acctgacaac gatccggaaa ctgctcctca ccactcccgt catgcctgct   7380

gtcggcgttt gaccttccac gtgacagttc ttcacaattc ctttcatcat tttttaaata   7440

ttttttttac tgcctatggg ctgtgatgta tatagaagtt gtacattaaa cataccctca   7500

tttttttctt ttcttttttt tttttttttt tagtacaaag ttttagtttc tttttcatga   7560

tgtggtaact acgaagtgat ggtagattta aataattttt tatttttatt ttatatattt   7620

tttcattagg gccatatctc caaaaaaaga aagaaaaaat acaaaaaaca aaaacaaaaa   7680

aaaaagaggg taatgtacaa gtttctgtat gtataaagtc atgctcgatt tcaggagagc   7740

agctgatcac aatttgcttc atgaatcaag gtgtggaaat ggttatatat ggattgattt   7800

agaaaatggt taccagtaca gtcaaaaaag agaaaatgaa aaaaatacaa ctaaaaggaa   7860

gaaacacaac ttcaaagatt tttcagtgat gagaatccac atttgtattt caagataatg   7920

tagtttaaaa aaaaaaaaaa gaaaaaaact tgatgtaaat tcctcctttt cctctggctt   7980

aatgaatatc atttattcag tataaaatct ttatatgttc cacatgttaa gaataaatgt   8040

acattaaatc ttgttaagca ctgtgaaaaa aaaaaaaaaa aaaaaaa                 8087


<210>  1884
<211>  2178
<212>  PRT
<213>  Homosapiens

<400>  1884

Met Glu Thr Gly Leu Leu Pro Asn His Lys Leu Lys Thr Val Gly Glu 
1               5                   10                  15      


Ala Pro Ala Ala Pro Pro His Gln Gln His His His His His His Ala 
            20                  25                  30          


His His His His His His Ala His His Leu His His His His Ala Leu 
        35                  40                  45              


Gln Gln Gln Leu Asn Gln Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln His Pro Ile Ser Asn Asn Asn 
65                  70                  75                  80  


Ser Leu Gly Gly Ala Gly Gly Gly Ala Pro Gln Pro Gly Pro Asp Met 
                85                  90                  95      


Glu Gln Pro Gln His Gly Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln 
            100                 105                 110         


Ala Asp Pro Pro Gly Pro Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp 
        115                 120                 125             


Asp Ala Pro Pro Lys Met Gly Glu Pro Ala Gly Gly Arg Tyr Glu His 
    130                 135                 140                 


Pro Gly Leu Gly Ala Leu Gly Thr Gln Gln Pro Pro Val Ala Val Pro 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Pro Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr 
                165                 170                 175     


Gly Ser Ala Ala Pro Ala Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro 
            180                 185                 190         


Cys Phe Asp Gln His Gly Gly Gln Gln Ser Pro Gly Met Gly Met Met 
        195                 200                 205             


His Ser Ala Ser Ala Ala Ala Ala Gly Ala Pro Gly Ser Met Asp Pro 
    210                 215                 220                 


Leu Gln Asn Ser His Glu Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr 
225                 230                 235                 240 


Pro Gly Tyr Ser Arg Pro Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly 
            260                 265                 270         


Ala Gly Gly Ala Gly Ala Gly Ala Val Ala Ala Ala Ala Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser 
    290                 295                 300                 


Ala Gly Tyr Gly Val Leu Ser Ser Pro Arg Gln Gln Gly Gly Gly Met 
305                 310                 315                 320 


Met Met Gly Pro Gly Gly Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala 
                325                 330                 335     


Ala Gly Ser Ala Ala Gly Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln 
            340                 345                 350         


His Pro Ser Gly Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro 
        355                 360                 365             


Ser Pro Met Met Arg Ser Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser 
    370                 375                 380                 


Pro Ser Ala Pro Pro Pro Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala 
385                 390                 395                 400 


Ala Ala Gly Ala Ala Ala Gly Gly Gln Gln Ala Ala Ala Gly Met Gly 
                405                 410                 415     


Leu Gly Lys Asp Met Gly Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp 
            420                 425                 430         


Ala Ala Ala Gln Gln Arg Ser His Pro Ala Met Ser Pro Gly Thr Pro 
        435                 440                 445             


Gly Pro Thr Met Gly Arg Ser Gln Gly Ser Pro Met Asp Pro Met Val 
    450                 455                 460                 


Met Lys Arg Pro Gln Leu Tyr Gly Met Gly Ser Asn Pro His Ser Gln 
465                 470                 475                 480 


Pro Gln Gln Ser Ser Pro Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly 
                485                 490                 495     


Pro Gln Arg Tyr Pro Ile Gly Ile Gln Gly Arg Thr Pro Gly Ala Met 
            500                 505                 510         


Ala Gly Met Gln Tyr Pro Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln 
        515                 520                 525             


Gln Gly Val Ser Gly Tyr Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser 
    530                 535                 540                 


Gln Gln Pro Gln Pro Pro His Leu Pro Pro Gln Ala Gln Tyr Leu Pro 
545                 550                 555                 560 


Ser Gln Ser Gln Gln Arg Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu 
                565                 570                 575     


Gly Tyr Gly Thr Arg Ser Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn 
            580                 585                 590         


His Glu Asp Leu Asn Leu Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro 
        595                 600                 605             


Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr 
    610                 615                 620                 


Leu Ser Ser Ala Val Ser Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp 
625                 630                 635                 640 


Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Ala Ser Pro His 
                645                 650                 655     


Leu Ser Ser Ile Pro Gly Gly Pro Ser Pro Ser Pro Val Gly Ser Pro 
            660                 665                 670         


Val Gly Ser Asn Gln Ser Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile 
        675                 680                 685             


Pro Gly Ser Gln Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser 
    690                 695                 700                 


Ser Ser His Pro Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly 
705                 710                 715                 720 


Phe Met Ala Gly Thr Gln Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro 
                725                 730                 735     


Gln Gln Thr Gly Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly Gln 
            740                 745                 750         


Met His Ala Gly Ile Ser Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr 
        755                 760                 765             


Tyr Gly Pro Gln Met Ser Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg 
    770                 775                 780                 


Pro Pro Ala Tyr Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly 
785                 790                 795                 800 


Pro Gly Met Gly Ile Ser Ala Asn Asn Gln Met His Gly Gln Gly Pro 
                805                 810                 815     


Ser Gln Pro Cys Gly Ala Val Pro Leu Gly Arg Met Pro Ser Ala Gly 
            820                 825                 830         


Met Gln Asn Arg Pro Phe Pro Gly Asn Met Ser Ser Met Thr Pro Ser 
        835                 840                 845             


Ser Pro Gly Met Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met 
    850                 855                 860                 


Pro Thr Val Asn Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met Gln 
865                 870                 875                 880 


Ala Ala Ala Asn Ser Ala Gln Ser Arg Gln Gly Ser Phe Pro Gly Met 
                885                 890                 895     


Asn Gln Ser Gly Leu Met Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met 
            900                 905                 910         


Asn Asn Ser Ser Ser Leu Met Asn Thr Gln Ala Pro Pro Tyr Ser Met 
        915                 920                 925             


Ala Pro Ala Met Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala Asp 
    930                 935                 940                 


Met Met Ser Pro Gly Glu Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp 
945                 950                 955                 960 


Gly Lys Glu Glu Gly Thr Pro Gln Pro Glu Ser Lys Ser Lys Lys Ser 
                965                 970                 975     


Ser Ser Ser Thr Thr Thr Gly Glu Lys Ile Thr Lys Val Tyr Glu Leu 
            980                 985                 990         


Gly Asn Glu Pro Glu Arg Lys Leu  Trp Val Asp Arg Tyr  Leu Thr Phe 
        995                 1000                 1005             


Met Glu  Glu Arg Gly Ser Pro  Val Ser Ser Leu Pro  Ala Val Gly 
    1010                 1015                 1020             


Lys Lys  Pro Leu Asp Leu Phe  Arg Leu Tyr Val Cys  Val Lys Glu 
    1025                 1030                 1035             


Ile Gly  Gly Leu Ala Gln Val  Asn Lys Asn Lys Lys  Trp Arg Glu 
    1040                 1045                 1050             


Leu Ala  Thr Asn Leu Asn Val  Gly Thr Ser Ser Ser  Ala Ala Ser 
    1055                 1060                 1065             


Ser Leu  Lys Lys Gln Tyr Ile  Gln Tyr Leu Phe Ala  Phe Glu Cys 
    1070                 1075                 1080             


Lys Ile  Glu Arg Gly Glu Glu  Pro Pro Pro Glu Val  Phe Ser Thr 
    1085                 1090                 1095             


Gly Asp  Thr Lys Lys Gln Pro  Lys Leu Gln Pro Pro  Ser Pro Ala 
    1100                 1105                 1110             


Asn Ser  Gly Ser Leu Gln Gly  Pro Gln Thr Pro Gln  Ser Thr Gly 
    1115                 1120                 1125             


Ser Asn  Ser Met Ala Glu Val  Pro Gly Asp Leu Lys  Pro Pro Thr 
    1130                 1135                 1140             


Pro Ala  Ser Thr Pro His Gly  Gln Met Thr Pro Met  Gln Gly Gly 
    1145                 1150                 1155             


Arg Ser  Ser Thr Ile Ser Val  His Asp Pro Phe Ser  Asp Val Ser 
    1160                 1165                 1170             


Asp Ser  Ser Phe Pro Lys Arg  Asn Ser Met Thr Pro  Asn Ala Pro 
    1175                 1180                 1185             


Tyr Gln  Gln Gly Met Ser Met  Pro Asp Val Met Gly  Arg Met Pro 
    1190                 1195                 1200             


Tyr Glu  Pro Asn Lys Asp Pro  Phe Gly Gly Met Arg  Lys Val Pro 
    1205                 1210                 1215             


Gly Ser  Ser Glu Pro Phe Met  Thr Gln Gly Gln Met  Pro Asn Ser 
    1220                 1225                 1230             


Ser Met  Gln Asp Met Tyr Asn  Gln Ser Pro Ser Gly  Ala Met Ser 
    1235                 1240                 1245             


Asn Leu  Gly Met Gly Gln Arg  Gln Gln Phe Pro Tyr  Gly Ala Ser 
    1250                 1255                 1260             


Tyr Asp  Arg Arg His Glu Pro  Tyr Gly Gln Gln Tyr  Pro Gly Gln 
    1265                 1270                 1275             


Gly Pro  Pro Ser Gly Gln Pro  Pro Tyr Gly Gly His  Gln Pro Gly 
    1280                 1285                 1290             


Leu Tyr  Pro Gln Gln Pro Asn  Tyr Lys Arg His Met  Asp Gly Met 
    1295                 1300                 1305             


Tyr Gly  Pro Pro Ala Lys Arg  His Glu Gly Asp Met  Tyr Asn Met 
    1310                 1315                 1320             


Gln Tyr  Ser Ser Gln Gln Gln  Glu Met Tyr Asn Gln  Tyr Gly Gly 
    1325                 1330                 1335             


Ser Tyr  Ser Gly Pro Asp Arg  Arg Pro Ile Gln Gly  Gln Tyr Pro 
    1340                 1345                 1350             


Tyr Pro  Tyr Ser Arg Glu Arg  Met Gln Gly Pro Gly  Gln Ile Gln 
    1355                 1360                 1365             


Thr His  Gly Ile Pro Pro Gln  Met Met Gly Gly Pro  Leu Gln Ser 
    1370                 1375                 1380             


Ser Ser  Ser Glu Gly Pro Gln  Gln Asn Met Trp Ala  Ala Arg Asn 
    1385                 1390                 1395             


Asp Met  Pro Tyr Pro Tyr Gln  Asn Arg Gln Gly Pro  Gly Gly Pro 
    1400                 1405                 1410             


Thr Gln  Ala Pro Pro Tyr Pro  Gly Met Asn Arg Thr  Asp Asp Met 
    1415                 1420                 1425             


Met Val  Pro Asp Gln Arg Ile  Asn His Glu Ser Gln  Trp Pro Ser 
    1430                 1435                 1440             


His Val  Ser Gln Arg Gln Pro  Tyr Met Ser Ser Ser  Ala Ser Met 
    1445                 1450                 1455             


Gln Pro  Ile Thr Arg Pro Pro  Gln Pro Ser Tyr Gln  Thr Pro Pro 
    1460                 1465                 1470             


Ser Leu  Pro Asn His Ile Ser  Arg Ala Pro Ser Pro  Ala Ser Phe 
    1475                 1480                 1485             


Gln Arg  Ser Leu Glu Asn Arg  Met Ser Pro Ser Lys  Ser Pro Phe 
    1490                 1495                 1500             


Leu Pro  Ser Met Lys Met Gln  Lys Val Met Pro Thr  Val Pro Thr 
    1505                 1510                 1515             


Ser Gln  Val Thr Gly Pro Pro  Pro Gln Pro Pro Pro  Ile Arg Arg 
    1520                 1525                 1530             


Glu Ile  Thr Phe Pro Pro Gly  Ser Val Glu Ala Ser  Gln Pro Val 
    1535                 1540                 1545             


Leu Lys  Gln Arg Arg Lys Ile  Thr Ser Lys Asp Ile  Val Thr Pro 
    1550                 1555                 1560             


Glu Ala  Trp Arg Val Met Met  Ser Leu Lys Ser Gly  Leu Leu Ala 
    1565                 1570                 1575             


Glu Ser  Thr Trp Ala Leu Asp  Thr Ile Asn Ile Leu  Leu Tyr Asp 
    1580                 1585                 1590             


Asp Ser  Thr Val Ala Thr Phe  Asn Leu Ser Gln Leu  Ser Gly Phe 
    1595                 1600                 1605             


Leu Glu  Leu Leu Val Glu Tyr  Phe Arg Lys Cys Leu  Ile Asp Ile 
    1610                 1615                 1620             


Phe Gly  Ile Leu Met Glu Tyr  Glu Val Gly Asp Pro  Ser Gln Lys 
    1625                 1630                 1635             


Ala Leu  Asp His Asn Ala Ala  Arg Lys Asp Asp Ser  Gln Ser Leu 
    1640                 1645                 1650             


Ala Asp  Asp Ser Gly Lys Glu  Glu Glu Asp Ala Glu  Cys Ile Asp 
    1655                 1660                 1665             


Asp Asp  Glu Glu Asp Glu Glu  Asp Glu Glu Glu Asp  Ser Glu Lys 
    1670                 1675                 1680             


Thr Glu  Ser Asp Glu Lys Ser  Ser Ile Ala Leu Thr  Ala Pro Asp 
    1685                 1690                 1695             


Ala Ala  Ala Asp Pro Lys Glu  Lys Pro Lys Gln Ala  Ser Lys Phe 
    1700                 1705                 1710             


Asp Lys  Leu Pro Ile Lys Ile  Val Lys Lys Asn Asn  Leu Phe Val 
    1715                 1720                 1725             


Val Asp  Arg Ser Asp Lys Leu  Gly Arg Val Gln Glu  Phe Asn Ser 
    1730                 1735                 1740             


Gly Leu  Leu His Trp Gln Leu  Gly Gly Gly Asp Thr  Thr Glu His 
    1745                 1750                 1755             


Ile Gln  Thr His Phe Glu Ser  Lys Met Glu Ile Pro  Pro Arg Arg 
    1760                 1765                 1770             


Arg Pro  Pro Pro Pro Leu Ser  Ser Ala Gly Arg Lys  Lys Glu Gln 
    1775                 1780                 1785             


Glu Gly  Lys Gly Asp Ser Glu  Glu Gln Gln Glu Lys  Ser Ile Ile 
    1790                 1795                 1800             


Ala Thr  Ile Asp Asp Val Leu  Ser Ala Arg Pro Gly  Ala Leu Pro 
    1805                 1810                 1815             


Glu Asp  Ala Asn Pro Gly Pro  Gln Thr Glu Ser Ser  Lys Phe Pro 
    1820                 1825                 1830             


Phe Gly  Ile Gln Gln Ala Lys  Ser His Arg Asn Ile  Lys Leu Leu 
    1835                 1840                 1845             


Glu Asp  Glu Pro Arg Ser Arg  Asp Glu Thr Pro Leu  Cys Thr Ile 
    1850                 1855                 1860             


Ala His  Trp Gln Asp Ser Leu  Ala Lys Arg Cys Ile  Cys Val Ser 
    1865                 1870                 1875             


Asn Ile  Val Arg Ser Leu Ser  Phe Val Pro Gly Asn  Asp Ala Glu 
    1880                 1885                 1890             


Met Ser  Lys His Pro Gly Leu  Val Leu Ile Leu Gly  Lys Leu Ile 
    1895                 1900                 1905             


Leu Leu  His His Glu His Pro  Glu Arg Lys Arg Ala  Pro Gln Thr 
    1910                 1915                 1920             


Tyr Glu  Lys Glu Glu Asp Glu  Asp Lys Gly Val Ala  Cys Ser Lys 
    1925                 1930                 1935             


Asp Glu  Trp Trp Trp Asp Cys  Leu Glu Val Leu Arg  Asp Asn Thr 
    1940                 1945                 1950             


Leu Val  Thr Leu Ala Asn Ile  Ser Gly Gln Leu Asp  Leu Ser Ala 
    1955                 1960                 1965             


Tyr Thr  Glu Ser Ile Cys Leu  Pro Ile Leu Asp Gly  Leu Leu His 
    1970                 1975                 1980             


Trp Met  Val Cys Pro Ser Ala  Glu Ala Gln Asp Pro  Phe Pro Thr 
    1985                 1990                 1995             


Val Gly  Pro Asn Ser Val Leu  Ser Pro Gln Arg Leu  Val Leu Glu 
    2000                 2005                 2010             


Thr Leu  Cys Lys Leu Ser Ile  Gln Asp Asn Asn Val  Asp Leu Ile 
    2015                 2020                 2025             


Leu Ala  Thr Pro Pro Phe Ser  Arg Gln Glu Lys Phe  Tyr Ala Thr 
    2030                 2035                 2040             


Leu Val  Arg Tyr Val Gly Asp  Arg Lys Asn Pro Val  Cys Arg Glu 
    2045                 2050                 2055             


Met Ser  Met Ala Leu Leu Ser  Asn Leu Ala Gln Gly  Asp Ala Leu 
    2060                 2065                 2070             


Ala Ala  Arg Ala Ile Ala Val  Gln Lys Gly Ser Ile  Gly Asn Leu 
    2075                 2080                 2085             


Ile Ser  Phe Leu Glu Asp Gly  Val Thr Met Ala Gln  Tyr Gln Gln 
    2090                 2095                 2100             


Ser Gln  His Asn Leu Met His  Met Gln Pro Pro Pro  Leu Glu Pro 
    2105                 2110                 2115             


Pro Ser  Val Asp Met Met Cys  Arg Ala Ala Lys Ala  Leu Leu Ala 
    2120                 2125                 2130             


Met Ala  Arg Val Asp Glu Asn  Arg Ser Glu Phe Leu  Leu His Glu 
    2135                 2140                 2145             


Gly Arg  Leu Leu Asp Ile Ser  Ile Ser Ala Val Leu  Asn Ser Leu 
    2150                 2155                 2160             


Val Ala  Ser Val Ile Cys Asp  Val Leu Phe Gln Ile  Gly Gln Leu 
    2165                 2170                 2175             


<210>  1885
<211>  2821
<212>  DNA
<213>  Homosapiens

<400>  1885
gaaggagtgg acccaacctg gccgcgccgc agaagtggct cccgaggaag ccggcgccgg     60

ggccgccgcc tcgtgtcccc tcggggcgca gtgctcgggg gtcggcgggc cagagccgag    120

gcgcggccgg ggagccgggg gctgcggggc cgagcgggca gccgcgcgag ggggcgggcg    180

ctcggcgacc cgggggccgg ccgggctgag ccccgcgccc cgggacgcgg gctggaagcg    240

acggaggagt gctgccgcgg gctgcggacc agcgccgtcc cctcacggag cggggattct    300

gctatgacag ttgggctccc cggagggtta acctgggtgt cctcggcaaa gttgtcgccg    360

agccgggagc ccgtgtaggg gccgcggcgc cgcggctcgg ggggcggccg ggcggccggc    420

ggcggtcgtg gctcggcggg gcccgcgcgg ccggggggct cctgggggtg tgcgccccca    480

gccggctgcc ctcgtggatg cctcccggcg gcggcgggcc catgaaagac tgcgagtaca    540

gccagatcag cacccacagc tcctccccca tggagtcgcc ccacaagaag aagaaaatcg    600

cggcccggag gaaatgggag gtgttcccgg gaagaaacaa gttcttctgt aacgggagga    660

tcatgatggc ccggcagacg ggcgtcttct acctgacgct cgtcctcatc ctggtcacta    720

gcggactctt cttcgccttc gactgtccgt acctggcggt gaaaatcacc cctgccatcc    780

ctgcagtcgc tggcatcctg ttcttctttg tgatggggac cctgctccgc accagcttca    840

gcgaccccgg agtcctccca cgagccacgc ctgatgaagc cgccgatctg gaaaggcaaa    900

tagatatcgc aaacggcacc agttcagggg ggtaccgccc gcctcccaga accaaagaag    960

tcatcatcaa tggccagacc gtgaaactta aatactgttt cacctgcaag attttccggc   1020

cccctcgcgc ctcccattgc agcctttgtg ataactgcgt agaacggttt gatcaccact   1080

gtccctgggt aggcaactgt gtggggaaaa gaaactacag atttttttat atgtttattt   1140

tatctctgtc ttttctgaca gtctttatat ttgcattcgt tatcacccac gtcattcttc   1200

gttcacagca aacaggattc ctaaatgccc ttaaggacag tcctgcaagc gtcctggagg   1260

ctgtggtgtg cttcttctct gtctggtcca tcgttggcct ctcaggattc cacacctact   1320

tgatcagctc caaccagaca acaaatgagg acattaaagg atcctggtca aataaaagag   1380

gtaaagaaaa ttacaatccc tacagctacg gaaatatctt taccaactgc tgtgttgccc   1440

tgtgtgggcc catctcacca agcctgatcg acagaagagg gtacatccag cccgacacgc   1500

cgcagccagc agcaccctcc aatggcatca ccatgtacgg ggccacgcag tcacagagtg   1560

acatgtgcga ccaagaccag tgcattcaga gcaccaaatt cgttttgcag gctgcagcca   1620

cgcccctgct gcagagcgag cccagcctca ccagcgacga gctgcacctg cccgggaagc   1680

ctggcctggg cacgccctgc gccagcctca cactgggccc gcccacaccg cccgcctcca   1740

tgcccaacct cgccgaggcc acgctcgcgg acgtgatgcc ccggaaagat gagcacatgg   1800

gccaccagtt cctgacgccc gatgaggcgc cctcgccccc caggctactg gcggcgggca   1860

gccccctggc gcacagccgc accatgcacg tgctgggcct ggccagccag gactccctgc   1920

atgaggactc tgtgcgcggc ctggtgaagc tcagctccgt gtgacccaca tggccccagg   1980

ccgggggaca ccagaggctc ctccatgggc agcaggagtg agcggagggg tgtgtcccac   2040

agcgactttc ccagccaatg ccacggtgga gatgacagcc ccaggtctgg ggtacagaga   2100

ccacttagga tggcacaggg tggctggccc cggatgctga gagcttggtt tcatttgaat   2160

tttcttcccc aacctgagtg ctttgacaac aatggaaata gagaagtggc tgctttcttt   2220

tggtgaccct ccaggggtgg aatcggagtg tgtctgcccg cccttgtgac agacacacgg   2280

aaggcttctg acgcttgtgg ccagactgca attgcactta tgtgttatgc tactaatatt   2340

tgaaacagac ctgccattcc atttgttaat taaaaaaaaa aaaaatccta aagggaaaaa   2400

accgaccagg tgtggatctg catgccacgc tgccgtctgt gttacagtgg tgttgctatt   2460

tccaaggaag tgctgctttc tttttctttt tttaattttg tgaattttca agtgctgttt   2520

tgttggaaga cagtgcaacg aactgagact aatggacagt gtcatcactc agcttactgg   2580

gctgaggcgt ctgtggagag gtggcaccgg ggctgcagag ggcggctggg gttccgtcgt   2640

gtcgggtgtc acttcacctt ctgtttggcc gctcgatgag gtctcgtgtt gagatattgt   2700

gtgccacaac ccccacagtc ttcacctccg tgtgtgatga aacttcccgt ggacagccaa   2760

taaaatgacg tcctctgtta ttttggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2820

a                                                                   2821


<210>  1886
<211>  488
<212>  PRT
<213>  Homosapiens

<400>  1886

Met Pro Pro Gly Gly Gly Gly Pro Met Lys Asp Cys Glu Tyr Ser Gln 
1               5                   10                  15      


Ile Ser Thr His Ser Ser Ser Pro Met Glu Ser Pro His Lys Lys Lys 
            20                  25                  30          


Lys Ile Ala Ala Arg Arg Lys Trp Glu Val Phe Pro Gly Arg Asn Lys 
        35                  40                  45              


Phe Phe Cys Asn Gly Arg Ile Met Met Ala Arg Gln Thr Gly Val Phe 
    50                  55                  60                  


Tyr Leu Thr Leu Val Leu Ile Leu Val Thr Ser Gly Leu Phe Phe Ala 
65                  70                  75                  80  


Phe Asp Cys Pro Tyr Leu Ala Val Lys Ile Thr Pro Ala Ile Pro Ala 
                85                  90                  95      


Val Ala Gly Ile Leu Phe Phe Phe Val Met Gly Thr Leu Leu Arg Thr 
            100                 105                 110         


Ser Phe Ser Asp Pro Gly Val Leu Pro Arg Ala Thr Pro Asp Glu Ala 
        115                 120                 125             


Ala Asp Leu Glu Arg Gln Ile Asp Ile Ala Asn Gly Thr Ser Ser Gly 
    130                 135                 140                 


Gly Tyr Arg Pro Pro Pro Arg Thr Lys Glu Val Ile Ile Asn Gly Gln 
145                 150                 155                 160 


Thr Val Lys Leu Lys Tyr Cys Phe Thr Cys Lys Ile Phe Arg Pro Pro 
                165                 170                 175     


Arg Ala Ser His Cys Ser Leu Cys Asp Asn Cys Val Glu Arg Phe Asp 
            180                 185                 190         


His His Cys Pro Trp Val Gly Asn Cys Val Gly Lys Arg Asn Tyr Arg 
        195                 200                 205             


Phe Phe Tyr Met Phe Ile Leu Ser Leu Ser Phe Leu Thr Val Phe Ile 
    210                 215                 220                 


Phe Ala Phe Val Ile Thr His Val Ile Leu Arg Ser Gln Gln Thr Gly 
225                 230                 235                 240 


Phe Leu Asn Ala Leu Lys Asp Ser Pro Ala Ser Val Leu Glu Ala Val 
                245                 250                 255     


Val Cys Phe Phe Ser Val Trp Ser Ile Val Gly Leu Ser Gly Phe His 
            260                 265                 270         


Thr Tyr Leu Ile Ser Ser Asn Gln Thr Thr Asn Glu Asp Ile Lys Gly 
        275                 280                 285             


Ser Trp Ser Asn Lys Arg Gly Lys Glu Asn Tyr Asn Pro Tyr Ser Tyr 
    290                 295                 300                 


Gly Asn Ile Phe Thr Asn Cys Cys Val Ala Leu Cys Gly Pro Ile Ser 
305                 310                 315                 320 


Pro Ser Leu Ile Asp Arg Arg Gly Tyr Ile Gln Pro Asp Thr Pro Gln 
                325                 330                 335     


Pro Ala Ala Pro Ser Asn Gly Ile Thr Met Tyr Gly Ala Thr Gln Ser 
            340                 345                 350         


Gln Ser Asp Met Cys Asp Gln Asp Gln Cys Ile Gln Ser Thr Lys Phe 
        355                 360                 365             


Val Leu Gln Ala Ala Ala Thr Pro Leu Leu Gln Ser Glu Pro Ser Leu 
    370                 375                 380                 


Thr Ser Asp Glu Leu His Leu Pro Gly Lys Pro Gly Leu Gly Thr Pro 
385                 390                 395                 400 


Cys Ala Ser Leu Thr Leu Gly Pro Pro Thr Pro Pro Ala Ser Met Pro 
                405                 410                 415     


Asn Leu Ala Glu Ala Thr Leu Ala Asp Val Met Pro Arg Lys Asp Glu 
            420                 425                 430         


His Met Gly His Gln Phe Leu Thr Pro Asp Glu Ala Pro Ser Pro Pro 
        435                 440                 445             


Arg Leu Leu Ala Ala Gly Ser Pro Leu Ala His Ser Arg Thr Met His 
    450                 455                 460                 


Val Leu Gly Leu Ala Ser Gln Asp Ser Leu His Glu Asp Ser Val Arg 
465                 470                 475                 480 


Gly Leu Val Lys Leu Ser Ser Val 
                485             


<210>  1887
<211>  2774
<212>  DNA
<213>  Homosapiens

<400>  1887
gaaggagtgg acccaacctg gccgcgccgc agaagtggct cccgaggaag ccggcgccgg     60

ggccgccgcc tcgtgtcccc tcggggcgca gtgctcgggg gtcggcgggc cagagccgag    120

gcgcggccgg ggagccgggg gctgcggggc cgagcgggca gccgcgcgag ggggcgggcg    180

ctcggcgacc cgggggccgg ccgggctgag ccccgcgccc cgggacgcgg gctggaagcg    240

acggaggagt gctgccgcgg gctgcggacc agcgccgtcc cctcacggag cggggattct    300

gctatgacag ttgggctccc cggagggtta acctgggtgt cctcggcaaa gttgtcgccg    360

agccgggagc ccgtgtaggg gccgcggcgc cgcggctcgg ggggcggccg ggcggccggc    420

ggcggtcgtg gctcggcggg gcccgcgcgg ccggggggct cctgggggtg tgcgccccca    480

gccggctgcc ctcgtggatg cctcccggcg gcggcgggcc catgaaagac tgcgagtaca    540

gccagatcag cacccacagc tcctccccca tggagtcgcc ccacaagaag aagaaaatcg    600

cggcccggag gaaatgggag gtgttcccgg gaagaaacaa gttcttctgt aacgggagga    660

tcatgatggc ccggcagacg ggcgtcttct acctgacgct cgtcctcatc ctggtcacta    720

gcggactctt cttcgccttc gactgtccgt acctggcggt gaaaatcacc cctgccatcc    780

ctgcagtcgc tggcatcctg ttcttctttg tgatggggac cctgctccgc accagcttca    840

gcgaccccgg agtcctccca cgagccacgc ctgatgaagc cgccgatctg gaaaggcaaa    900

tagatatcgc aaacggcacc agttcagggg ggtaccgccc gcctcccaga accaaagaag    960

tcatcatcaa tggccagacc gtgaaactta aatactgttt cacctgcaag attttccggc   1020

cccctcgcgc ctcccattgc agcctttgtg ataactgcgt agaacggttt gatcaccact   1080

gtccctgggt aggcaactgt gtggggaaaa gaaactacag atttttttat atgtttattt   1140

tatctctgtc ttttctgaca gtctttatat ttgcattcgt tatcacccac gtcattcttc   1200

gttcacagca aacaggattc ctaaatgccc ttaaggacag tcctgcaagc gtcctggagg   1260

ctgtggtgtg cttcttctct gtctggtcca tcgttggcct ctcaggattc cacacctact   1320

tgatcagctc caaccagaca acaaatgagg acattaaagg atcctggtca aataaaagag   1380

gtaaagaaaa ttacaatccc tacagctacg gaaatatctt taccaactgc tgtgttgccc   1440

tgtgtgggcc catctcacca agcctgatcg acagaagagg gtacatccag cccgacacgc   1500

cgcagccagc agcaccctcc aatggcatca ccatgtacgg ggccacgcag tcacagagtg   1560

acatggctgc agccacgccc ctgctgcaga gcgagcccag cctcaccagc gacgagctgc   1620

acctgcccgg gaagcctggc ctgggcacgc cctgcgccag cctcacactg ggcccgccca   1680

caccgcccgc ctccatgccc aacctcgccg aggccacgct cgcggacgtg atgccccgga   1740

aagatgagca catgggccac cagttcctga cgcccgatga ggcgccctcg ccccccaggc   1800

tactggcggc gggcagcccc ctggcgcaca gccgcaccat gcacgtgctg ggcctggcca   1860

gccaggactc cctgcatgag gactctgtgc gcggcctggt gaagctcagc tccgtgtgac   1920

ccacatggcc ccaggccggg ggacaccaga ggctcctcca tgggcagcag gagtgagcgg   1980

aggggtgtgt cccacagcga ctttcccagc caatgccacg gtggagatga cagccccagg   2040

tctggggtac agagaccact taggatggca cagggtggct ggccccggat gctgagagct   2100

tggtttcatt tgaattttct tccccaacct gagtgctttg acaacaatgg aaatagagaa   2160

gtggctgctt tcttttggtg accctccagg ggtggaatcg gagtgtgtct gcccgccctt   2220

gtgacagaca cacggaaggc ttctgacgct tgtggccaga ctgcaattgc acttatgtgt   2280

tatgctacta atatttgaaa cagacctgcc attccatttg ttaattaaaa aaaaaaaaaa   2340

tcctaaaggg aaaaaaccga ccaggtgtgg atctgcatgc cacgctgccg tctgtgttac   2400

agtggtgttg ctatttccaa ggaagtgctg ctttcttttt ctttttttaa ttttgtgaat   2460

tttcaagtgc tgttttgttg gaagacagtg caacgaactg agactaatgg acagtgtcat   2520

cactcagctt actgggctga ggcgtctgtg gagaggtggc accggggctg cagagggcgg   2580

ctggggttcc gtcgtgtcgg gtgtcacttc accttctgtt tggccgctcg atgaggtctc   2640

gtgttgagat attgtgtgcc acaaccccca cagtcttcac ctccgtgtgt gatgaaactt   2700

cccgtggaca gccaataaaa tgacgtcctc tgttattttg gaaaaaaaaa aaaaaaaaaa   2760

aaaaaaaaaa aaaa                                                     2774


<210>  1888
<211>  473
<212>  PRT
<213>  Homosapiens

<400>  1888

Met Pro Pro Gly Gly Gly Gly Pro Met Lys Asp Cys Glu Tyr Ser Gln 
1               5                   10                  15      


Ile Ser Thr His Ser Ser Ser Pro Met Glu Ser Pro His Lys Lys Lys 
            20                  25                  30          


Lys Ile Ala Ala Arg Arg Lys Trp Glu Val Phe Pro Gly Arg Asn Lys 
        35                  40                  45              


Phe Phe Cys Asn Gly Arg Ile Met Met Ala Arg Gln Thr Gly Val Phe 
    50                  55                  60                  


Tyr Leu Thr Leu Val Leu Ile Leu Val Thr Ser Gly Leu Phe Phe Ala 
65                  70                  75                  80  


Phe Asp Cys Pro Tyr Leu Ala Val Lys Ile Thr Pro Ala Ile Pro Ala 
                85                  90                  95      


Val Ala Gly Ile Leu Phe Phe Phe Val Met Gly Thr Leu Leu Arg Thr 
            100                 105                 110         


Ser Phe Ser Asp Pro Gly Val Leu Pro Arg Ala Thr Pro Asp Glu Ala 
        115                 120                 125             


Ala Asp Leu Glu Arg Gln Ile Asp Ile Ala Asn Gly Thr Ser Ser Gly 
    130                 135                 140                 


Gly Tyr Arg Pro Pro Pro Arg Thr Lys Glu Val Ile Ile Asn Gly Gln 
145                 150                 155                 160 


Thr Val Lys Leu Lys Tyr Cys Phe Thr Cys Lys Ile Phe Arg Pro Pro 
                165                 170                 175     


Arg Ala Ser His Cys Ser Leu Cys Asp Asn Cys Val Glu Arg Phe Asp 
            180                 185                 190         


His His Cys Pro Trp Val Gly Asn Cys Val Gly Lys Arg Asn Tyr Arg 
        195                 200                 205             


Phe Phe Tyr Met Phe Ile Leu Ser Leu Ser Phe Leu Thr Val Phe Ile 
    210                 215                 220                 


Phe Ala Phe Val Ile Thr His Val Ile Leu Arg Ser Gln Gln Thr Gly 
225                 230                 235                 240 


Phe Leu Asn Ala Leu Lys Asp Ser Pro Ala Ser Val Leu Glu Ala Val 
                245                 250                 255     


Val Cys Phe Phe Ser Val Trp Ser Ile Val Gly Leu Ser Gly Phe His 
            260                 265                 270         


Thr Tyr Leu Ile Ser Ser Asn Gln Thr Thr Asn Glu Asp Ile Lys Gly 
        275                 280                 285             


Ser Trp Ser Asn Lys Arg Gly Lys Glu Asn Tyr Asn Pro Tyr Ser Tyr 
    290                 295                 300                 


Gly Asn Ile Phe Thr Asn Cys Cys Val Ala Leu Cys Gly Pro Ile Ser 
305                 310                 315                 320 


Pro Ser Leu Ile Asp Arg Arg Gly Tyr Ile Gln Pro Asp Thr Pro Gln 
                325                 330                 335     


Pro Ala Ala Pro Ser Asn Gly Ile Thr Met Tyr Gly Ala Thr Gln Ser 
            340                 345                 350         


Gln Ser Asp Met Ala Ala Ala Thr Pro Leu Leu Gln Ser Glu Pro Ser 
        355                 360                 365             


Leu Thr Ser Asp Glu Leu His Leu Pro Gly Lys Pro Gly Leu Gly Thr 
    370                 375                 380                 


Pro Cys Ala Ser Leu Thr Leu Gly Pro Pro Thr Pro Pro Ala Ser Met 
385                 390                 395                 400 


Pro Asn Leu Ala Glu Ala Thr Leu Ala Asp Val Met Pro Arg Lys Asp 
                405                 410                 415     


Glu His Met Gly His Gln Phe Leu Thr Pro Asp Glu Ala Pro Ser Pro 
            420                 425                 430         


Pro Arg Leu Leu Ala Ala Gly Ser Pro Leu Ala His Ser Arg Thr Met 
        435                 440                 445             


His Val Leu Gly Leu Ala Ser Gln Asp Ser Leu His Glu Asp Ser Val 
    450                 455                 460                 


Arg Gly Leu Val Lys Leu Ser Ser Val 
465                 470             


<210>  1889
<211>  2704
<212>  DNA
<213>  Homosapiens

<400>  1889
gcgggaggcg gttcctgcag ggtccagtcc cgggagcacc cccaggagga ggggagggtg     60

ggagcgcctc tctttgagtc cccgggtttg gtcgctggga tgtgaggaag ccggagaggc    120

cgcggctgga cgcaggtggg tgtggagggg ccgcccggac tgcggggacc cgctccgcgc    180

acagtggctg agcgcccgcc tctctttcca ggggctgagg atccggcggc tcggctgcac    240

tatgcccttc ccgcccatgc cgccgccgcc cgcccccgcc ccgggggccc aagccgcgcg    300

ccagttaccc cggaggccct gcgccgcggg ggacaagaag aagaggcccc cacagcggcc    360

cgaggggctc ctctccagct cctggccctc cgccacgctc aagaggccgc cggcccggcg    420

cggccccggc ctggacagga cgcagccgcc ggcccctccg ggcgtctccc cccaggcctt    480

gcccagccgc gcgcgggccc cagccacgtg cgccccgccc cggccggcag gctccggcca    540

cagcccagcg aggaccacct atgcggcgac ctcggcgggg acggggacca ccgccgcggg    600

cacctcctcg ggggcggggc cttgtccaga ctccgctgcg cgcttctgcc tgaatctcac    660

ccccgaggcc gtcctggtca tccagaagcg tcatctggag aagcagctgc tggcgcggcc    720

ccgcaggccc ttcccctcac cctcggccga acccaggcgc ctactcgccc cgtgtctccc    780

ggctagggcc gcgggcccgc ggaggggcgg ccccgccagc gaccccgacg caccccccac    840

cgccggccag ggccgccgcg cgcctccgcc cggcgcccag ctgctgcacg gcggcctgca    900

ggttccccag ctcagcccgc ggcccggggc cctgcggccg atgctcaagg tgtcgctgct    960

caacgagcgg cacaggtacg acgacgtgga gtacgaggag gagccagagg cggtggacga   1020

gggcctggta cgcaagtgca cggagtggct gcgcggcgtg gagtccgcgg ctgccgcgcg   1080

gggccgggcg ggggccctgg actcacggcg gcacctgagc acgctgtgag cccagcgggc   1140

ctgcggggac aggccaggcc tgatcccacc tcacttcctg cacgcgccac tccgcctagg   1200

ggccctcggg ggagaccgca ggctcctctg gccgccagcg cccactttcg ggacaccagt   1260

gcgcaagctg gcccacgtgg ggcgcagcca gactcgcccg acggccacgg cccccctcct   1320

gccctcgcca gccggcagcc cgggcctttc tcgttcacac cggtggtatc taccccagat   1380

gcctgcctct gcccccactc tggcctcctc ttggcatcgc cgagcatcca tgcagttcgt   1440

ggggaattaa gcaactgaga aaatgcctct tggtgccccg acccccaggg ttcgtctagg   1500

tcccagagac cctctgcctg gaggcgggcc ttccccaggg ctacatctgc acgccccgtg   1560

gtgtcaccct cagccggcgc cgggcaccct ggacagtgcg gtgggcgatg gcccaggtgg   1620

gtggccgcga cggtggcctc ctgcagagct gggacccggt cctacattcg tgattttgtt   1680

ttctcccaag tcagaaaaat gttgagggta ttagacatcc ctgaaactca gttaaccgaa   1740

tttccagtct ccaaagcgga agggtaggca tcgccaggcg ctggtgagcc ctggtcaatg   1800

agcgcttcca tggaaaccgc tcggctgatt acattttttc tgtgtattat ttgaatagag   1860

agtaaagctc ctccgctgtt tcgtaaccat atcctttccc ccgctaactg gaggctgatt   1920

tctacatatt tcttccatgt atctgagaat atctaactag aaggatgaga aggaaataaa   1980

atgttataat cagataaggc tggttataaa agagtaatgt attacctcaa tttttgactg   2040

actttgtaaa agccaataac tggtttaatg tttatcttga tagactttaa atgtatcaag   2100

tcttaattgt attttaaatt gaagccttac atttttaaaa cagattttgt atttttcttg   2160

tggaggtctt tgctctaata acacacacac actgtctctc tctctctctc tctctaattc   2220

taggcacaca tttagttaga tgtgaagcat ttaattcatt gggagctagg tcagctgcca   2280

gatgagttgc aaaaacagaa aaaaacctac ccattgaata acttctttga atttggagat   2340

aagttttctt ttacttaaaa tgaatatatt aattctagag gggcaaaact agcaatgctt   2400

atgcaagtga cggtgctgct cttgttccac ccccacccag atggtctctg agtgcgccgt   2460

cctgggcagg gcacacggtc tggagctgag agggtggagc aagagtgcac tgactccgag   2520

ccgagggcag gagtggctca acttggtctc gtcttgcact tagtgcaaat accaataatt   2580

aagatgccta gacttctgcc cttggtcaca gtaacaacaa cattttgaag acttttccct   2640

ggtggcatcc tagagggacc gactttctgc agcctctgtc ttccaagctg agcttctgct   2700

gcag                                                                2704


<210>  1890
<211>  295
<212>  PRT
<213>  Homosapiens

<400>  1890

Met Pro Phe Pro Pro Met Pro Pro Pro Pro Ala Pro Ala Pro Gly Ala 
1               5                   10                  15      


Gln Ala Ala Arg Gln Leu Pro Arg Arg Pro Cys Ala Ala Gly Asp Lys 
            20                  25                  30          


Lys Lys Arg Pro Pro Gln Arg Pro Glu Gly Leu Leu Ser Ser Ser Trp 
        35                  40                  45              


Pro Ser Ala Thr Leu Lys Arg Pro Pro Ala Arg Arg Gly Pro Gly Leu 
    50                  55                  60                  


Asp Arg Thr Gln Pro Pro Ala Pro Pro Gly Val Ser Pro Gln Ala Leu 
65                  70                  75                  80  


Pro Ser Arg Ala Arg Ala Pro Ala Thr Cys Ala Pro Pro Arg Pro Ala 
                85                  90                  95      


Gly Ser Gly His Ser Pro Ala Arg Thr Thr Tyr Ala Ala Thr Ser Ala 
            100                 105                 110         


Gly Thr Gly Thr Thr Ala Ala Gly Thr Ser Ser Gly Ala Gly Pro Cys 
        115                 120                 125             


Pro Asp Ser Ala Ala Arg Phe Cys Leu Asn Leu Thr Pro Glu Ala Val 
    130                 135                 140                 


Leu Val Ile Gln Lys Arg His Leu Glu Lys Gln Leu Leu Ala Arg Pro 
145                 150                 155                 160 


Arg Arg Pro Phe Pro Ser Pro Ser Ala Glu Pro Arg Arg Leu Leu Ala 
                165                 170                 175     


Pro Cys Leu Pro Ala Arg Ala Ala Gly Pro Arg Arg Gly Gly Pro Ala 
            180                 185                 190         


Ser Asp Pro Asp Ala Pro Pro Thr Ala Gly Gln Gly Arg Arg Ala Pro 
        195                 200                 205             


Pro Pro Gly Ala Gln Leu Leu His Gly Gly Leu Gln Val Pro Gln Leu 
    210                 215                 220                 


Ser Pro Arg Pro Gly Ala Leu Arg Pro Met Leu Lys Val Ser Leu Leu 
225                 230                 235                 240 


Asn Glu Arg His Arg Tyr Asp Asp Val Glu Tyr Glu Glu Glu Pro Glu 
                245                 250                 255     


Ala Val Asp Glu Gly Leu Val Arg Lys Cys Thr Glu Trp Leu Arg Gly 
            260                 265                 270         


Val Glu Ser Ala Ala Ala Ala Arg Gly Arg Ala Gly Ala Leu Asp Ser 
        275                 280                 285             


Arg Arg His Leu Ser Thr Leu 
    290                 295 


<210>  1891
<211>  717
<212>  DNA
<213>  Homosapiens

<400>  1891
gcacgagggc tacggccctg gaacggggcc atggagaagc tgcggcgagt cctgagcggc     60

caggacgacg aggagcaggg cctgactgcg caggtcctgg atgcctcatc ccttagtttc    120

aacaccagat tgaaatggtt tgccatctgc ttcgtatgtg gcgttttctt ttctattctt    180

ggaactggat tgctgtggct tccgggcggc ataaagcttt ttgcagtgtt ttataccctc    240

ggcaatcttg ctgcgttagc cagtacatgc tttttaatgg gacctgtgaa gcaactgaag    300

aaaatgtttg aagcaacaag attgcttgca acaattgtta tgcttttgtg tttcatattt    360

accctgtgtg ctgctctttg gtggcataag aagggactgg ctgtgttatt ctgcatattg    420

cagttcttgt caatgacctg gtatagcctg tcatacatcc catatgcaag ggatgcagtt    480

attaaatgct gttcttctct cctaagttga aaatcagaaa cttgtggaaa agagcacttg    540

aatgttggta ctctatgttt ggtgaagttt gcttttcccc ataaaacact ccaggaacaa    600

ctgacgtgac agttgaagac cgttttgtac taagtctcat tttgtatact ggtaaaaact    660

acatgcttga ttaaaccatt aaatgcttgt aactttaaaa aaaaaaaaaa aaaaaaa       717


<210>  1892
<211>  159
<212>  PRT
<213>  Homosapiens

<400>  1892

Met Glu Lys Leu Arg Arg Val Leu Ser Gly Gln Asp Asp Glu Glu Gln 
1               5                   10                  15      


Gly Leu Thr Ala Gln Val Leu Asp Ala Ser Ser Leu Ser Phe Asn Thr 
            20                  25                  30          


Arg Leu Lys Trp Phe Ala Ile Cys Phe Val Cys Gly Val Phe Phe Ser 
        35                  40                  45              


Ile Leu Gly Thr Gly Leu Leu Trp Leu Pro Gly Gly Ile Lys Leu Phe 
    50                  55                  60                  


Ala Val Phe Tyr Thr Leu Gly Asn Leu Ala Ala Leu Ala Ser Thr Cys 
65                  70                  75                  80  


Phe Leu Met Gly Pro Val Lys Gln Leu Lys Lys Met Phe Glu Ala Thr 
                85                  90                  95      


Arg Leu Leu Ala Thr Ile Val Met Leu Leu Cys Phe Ile Phe Thr Leu 
            100                 105                 110         


Cys Ala Ala Leu Trp Trp His Lys Lys Gly Leu Ala Val Leu Phe Cys 
        115                 120                 125             


Ile Leu Gln Phe Leu Ser Met Thr Trp Tyr Ser Leu Ser Tyr Ile Pro 
    130                 135                 140                 


Tyr Ala Arg Asp Ala Val Ile Lys Cys Cys Ser Ser Leu Leu Ser 
145                 150                 155                 


<210>  1893
<211>  3883
<212>  DNA
<213>  Homosapiens

<400>  1893
ctcggacccg gtagtggtcc gtgaagtccg cggagtgggc gctgatggtg gggctatccc     60

ttcccactgt ccgcgaggtg cgccgtggta acgcgcgggg acacagcgcg ggtgtggacc    120

ccctgcccac agctggcgca cagccattga gtgtagaccc gactggggca cgaccactga    180

accctgcact tggcgtcctc cgggccccgc gaggggcctt gctgggcggg tccgcggcac    240

cccgggttcc cagaagtcga ggccccgaat gcgcctcccc tcgcctggaa tcggagagcg    300

gagggctcct gcgggcaggt ggccgtgctc cgaagagcgc cctgccaccc atgaggtggc    360

cctgggggcg tcgctagcct tcccagctgg gtgtcctcat ccggagacac aaacacctgc    420

ctcaggatta aagcgaggag ctgtatttca gaccgtctca ggagaaatag caagaggctg    480

cctcactcct ttgcccttgt tcaagtttga ggcattaaga aggataagac atcaatttga    540

aaagagcccc tgtcagagca acatgacttg aaagcaagaa gaaaaaacaa aaaatgaagc    600

aagaacaaac atcaaattta tgctgagttt ggctgcaaga atggtgaaat cattgatact    660

ttacaagaca ctaatcagga cagtgcccca aaggaatcag cagtttacaa atggatataa    720

cctgttttca gaagagacaa gattaatttg aagatgaagc agtggcggac catccatgtc    780

aatttatgag aaaaaaattc attctgttca tgccctaact gaagaggact gacaacagca    840

caaacaatag ccaacatcat agacatctca actggttcag cttactcaat tctgactgaa    900

agttaaagtt gagcaaactt tccactcaat gagtgtcgaa accctcatgc ccagatcagc    960

tgcagacaag agcagaggtt tcaatggaaa ttttaaacaa gtgagattaa gatcctgaag   1020

catttcttga aagaattgta acaggagata aaccatggct tcaccagtac aatactgaag   1080

actaagcaca atcaaagcaa tggctaccaa gaggccgaag tggtcccatt aaggcgaaag   1140

tggaccagtc aagagcaaag gtcatggcaa cagtgttttg ggatgccaag acattttgct   1200

cgttgacttt ctggagggcc aaagtgcagt aatgtctgtt tattatgttt tgagaaagtt   1260

ggccaaacct ttagtagaaa aatgcccagg agaacttcac tagagtgacc ttcgttcaat   1320

ttcagatcac cacaataaag caaaaaattg caattataaa ttttttggtt tcccagtaca   1380

tgtaaaagtt ataattacac tatactatag tctattaagg gtgcaatagc attatgtctg   1440

aaaaaaacaa tggtcatgcc ttaatttaaa aatactttat tactaaaaaa tgctagcaat   1500

catctgaacc ttcagtgagt cataatattt ttgctagtgg agggccttgc ctggatgttg   1560

atggctgctg actgatcagg atggtggttg ctgaaggtta gggtggctgc agcaatttct   1620

taacataaga caacagtgaa gtttcctgca ttgattgact cttcctttca tgaaatattt   1680

ctctatagca tgtaatgctg tttgatagca ttttacccac agtagaattt atttcagaat   1740

tgaagtcagt cctcttaaac cctgtcactt ctttattaac taagttcacg caatattcta   1800

aatcctttgt tgtcatttca acaatgttca caacatcttc accagggata gattctgtct   1860

caagaaacca ctttctttgt tcattcgtaa gaagcaaccc ctcatctgtt caagttttct   1920

catgagattg gagcaattca gtcacatttt caggctgcat ttttaattct agttctcttg   1980

ctatttctac cacatctgca gttacttcct tcactgaagg cttgaacccc tcaaagtcac   2040

ccatgagggt tggaatcaac ttcttccaaa ttcctgttaa tgttgatgtt ttgacctcct   2100

ctcatgaatg atgaatgttt ttaatgacat ctaaaatggt cagtcctttc cagaaggttt   2160

tcaatttact ttgccccaat ccatcagagg aatcactgtc tatggcaact gtaggcttat   2220

aaaaggtatt tcttaaataa tatgtcttga aagtctaaat gactccttga tccataagct   2280

gcagaatggg tgttgtgtta gcaagcatga aaacaacatt catcttgtgc ctctccatct   2340

gagctcttct atgaccaggt gccttgttga tgagcagtaa tattttgaaa gaaatctttt   2400

ttcctgagca gtgggtctca acaatgggct taaaatgttc attaagccat gctgtaaaca   2460

gatgtgctat catccaggct ttgatgttcc ttatacagag tacaggcaca ggcagagtag   2520

atttagtata attcttaagg gcccttggat tttcagaatg gtaagtgaac attggtgtga   2580

acttaaggtc accagctgca ttagccccta acaagagagt cagcctgtcc tttgaagctt   2640

tgaagctagg cattgacttc tctctagcta tgaaagtcct agatgacatc ttctgattta   2700

aggctgtttt gtctacattg aaagtctatt atttagtgta gccaccttca tcaattatct   2760

tagtaaggtc ttctggataa cttgctgcag cttctacatc agcatttact gcttcacctc   2820

gcacttttat gttatggaga tggcttcatt ccttaaacct catgaaccaa cgagcttcaa   2880

acctttcttc tgcagcttcc tcacctccct caggcttcat agaatttaat agagttaggg   2940

ctttgctatg gattaggttt ttgcttatgg gaggattgtg gctggtttaa tcttctatcc   3000

agactactac aactttcccc atatcaaaaa taaggcactt tcattttttg atcatttgtt   3060

cactggagtg acacttactt ttaatttcct gaaaattttc ctttgcattt acaatgtagc   3120

taactattca gtggaagagg gctagttttt gacatgcctt cctcaatatg cttaataatt   3180

tctagttttt gatttaaagt gagacacatg tgactcttcc tttcacttga atgccgagag   3240

gccatgcagg gttattaatt agcctaattt caatattgtt atttaagtta tggggaggct   3300

tgaggagagg gagagagaga caggagaatg gccggtcagt ggagcagtca gaatacacac   3360

aacatatatt gattaacttt cctatcttat atgagcacag ttcttggcac tccaaaacaa   3420

ttacagtact aacatcaaag atcactgatc acagatcacc ataactgata ttataataat   3480

ggaaagtctt gaaatattgt gaaaattacc aaaatgtgac agatacaaca tgaacaaatg   3540

ctgttggaag aatggcactg atagatttgc ccaatgcagg gttgccacaa actttcaact   3600

tgtaaaaaga gcagtatctg tgaaagacgg taaagcagaa agcaataaaa tgaagtgtgc   3660

ccatgtatac taataagaca tagttcattt tattaataaa gcacctgtca atttcagttg   3720

agtaattttt atcaggaatg ggttttgaat tttgttcaag gcttttacag catctgtggg   3780

ataactatgt attgtttccc tggatctata aatacataca ggatactaat gacttttcaa   3840

atattgaacc aactttgcat tcttggaata aatctcactt gat                     3883


<210>  1894
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  1894

Met Val Gly Leu Ser Leu Pro Thr Val Arg Glu Val Arg Arg Gly Asn 
1               5                   10                  15      


Ala Arg Gly His Ser Ala Gly Val Asp Pro Leu Pro Thr Ala Gly Ala 
            20                  25                  30          


Gln Pro Leu Ser Val Asp Pro Thr Gly Ala Arg Pro Leu Asn Pro Ala 
        35                  40                  45              


Leu Gly Val Leu Arg Ala Pro Arg Gly Ala Leu Leu Gly Gly Ser Ala 
    50                  55                  60                  


Ala Pro Arg Val Pro Arg Ser Arg Gly Pro Glu Cys Ala Ser Pro Arg 
65                  70                  75                  80  


Leu Glu Ser Glu Ser Gly Gly Leu Leu Arg Ala Gly Gly Arg Ala Pro 
                85                  90                  95      


Lys Ser Ala Leu Pro Pro Met Arg Trp Pro Trp Gly Arg Arg 
            100                 105                 110 


<210>  1895
<211>  988
<212>  DNA
<213>  Homosapiens

<400>  1895
gtcgtgaggc gggccttcgg gctggctcgc cgtcggctgc cggggggttg gcctgggtgt     60

cattggctct gggaagcggc agcagaggca gggaccactc ggggtctggt gtcggcacag    120

ccatggcggg cgcgttggtg cggaaagcgg cggactatgt ccgaagcaag gatttccggg    180

actacctcat gagtacgcac ttctggggcc cagtagccaa ctggggtctt cccattgctg    240

ccatcaatga tatgaaaaag tctccagaga ttatcagtgg gcggatgaca tttgccctct    300

gttgctattc tttgacattc atgagatttg cctacaaggt acagcctcgg aactggcttc    360

tgtttgcatg ccacgcaaca aatgaagtag cccagctcat ccagggaggg cggcttatca    420

aacacgagat gactaaaacg gcatctgcat aacaatggga aaaggaagaa caaggtcttg    480

aagggacagc attgccagct gctgctgagt cacagatttc attataaata gcctccctaa    540

ggaaaataca ctgaatgcta tttttactaa ccattctatt tttatagaaa tagctgagag    600

tttctaaacc aactctctgc tgccttacaa gtattaaata ttttacttct ttccataaag    660

agtagctcaa aatatgcaat taatttaata atttctgatg atgttttatc tgcagtaata    720

tgtatatcat ctattagaat ttacttaatg aaaaactgaa gagaacaaaa tttgtaacca    780

ctagcactta agtactcctg attcttaaca ttgtctttaa tgaccacaag acaaccaaca    840

gctggccacg tacttaaaat tttgtcccca ctgtttaaaa atgttacctg tgtatttcca    900

tgcagtgtat atattgagat gctgtaactt aatggcaata aatgatttaa atatttgtta    960

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                       988


<210>  1896
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  1896

Met Ala Gly Ala Leu Val Arg Lys Ala Ala Asp Tyr Val Arg Ser Lys 
1               5                   10                  15      


Asp Phe Arg Asp Tyr Leu Met Ser Thr His Phe Trp Gly Pro Val Ala 
            20                  25                  30          


Asn Trp Gly Leu Pro Ile Ala Ala Ile Asn Asp Met Lys Lys Ser Pro 
        35                  40                  45              


Glu Ile Ile Ser Gly Arg Met Thr Phe Ala Leu Cys Cys Tyr Ser Leu 
    50                  55                  60                  


Thr Phe Met Arg Phe Ala Tyr Lys Val Gln Pro Arg Asn Trp Leu Leu 
65                  70                  75                  80  


Phe Ala Cys His Ala Thr Asn Glu Val Ala Gln Leu Ile Gln Gly Gly 
                85                  90                  95      


Arg Leu Ile Lys His Glu Met Thr Lys Thr Ala Ser Ala 
            100                 105                 


<210>  1897
<211>  5735
<212>  DNA
<213>  Homosapiens

<400>  1897
gcgtcccttg gcttccgaca tcccgtctgg ccgtccccct gtgccggtcc gagcctctgt     60

ttatttcctt tcctactatc aatactcgac cagcagaaaa ggaaagttta aaaatgccaa    120

tcgcacagtt gctggaacta tggaaaaaga tcgaggtgga gcctatggaa atagagacca    180

cagaggagga tctcaacctg gatgtggagc ccaccacaga agacactgca gaagaagaag    240

aaggcgtcgt gaaggagata gacatcagcc atcatgtgaa ggagggcttt gagaaggcag    300

atccttccca gtttgagctg ctgaaggttt taggacaagg atcctatgga aaggtgttcc    360

tggtgaggaa ggtgaagggg tccgacgctg ggcagctcta cgccatgaag gtccttaaga    420

aagccaccct aaaagttcgg gaccgagtga gatcgaagat ggagagagac atcttggcag    480

aagtgaatca ccccttcatt gtgaagcttc attatgcctt tcagacggaa ggaaagctct    540

acctgatcct ggacttcctg cggggagggg acctcttcac ccggctctcc aaagaggtca    600

tgttcacgga ggaggatgtc aagttctacc tggctgagct ggccttggct ttagaccatc    660

tccacagcct ggggatcatc tacagagatc tgaagcctga gaacatcctc ctggatgaag    720

aggggcacat taagatcaca gatttcggcc tgagtaagga ggccattgac cacgacaaga    780

gagcgtactc cttctgcggg acgatcgagt acatggcgcc cgaggtggtg aaccggcgag    840

gacacacgca gagtgccgac tggtggtcct tcggcgtgct catgtttgag atgctcacgg    900

ggtccctgcc gttccagggg aaggacagga aggagaccat ggctctcatc ctcaaagcca    960

agctggggat gccgcagttc ctcagtgggg aggcacagag tttgctgcga gctctcttca   1020

aacggaaccc ctgcaaccgg ctgggtgctg gcattgacgg agtggaggaa attaagcgcc   1080

atcccttctt tgtgaccata gactggaaca cgctgtaccg gaaggagatc aagccaccgt   1140

tcaaaccagc agtgggcagg cctgaggaca ccttccactt tgaccccgag ttcacagcgc   1200

ggacgcccac agactctcct ggcgtccccc cgagtgcaaa cgctcatcac ctgtttagag   1260

gattcagctt tgtggcctca agcctgatcc aggagccctc acagcaagat ctgcacaaag   1320

tcccagttca cccaatcgtg cagcagttac acgggaacaa catccacttc accgatggct   1380

acgagatcaa ggaggacatc ggggtgggct cctactcagt gtgcaagcga tgtgtgcata   1440

aagccacaga caccgagtat gccgtgaaga tcattgataa gagcaagaga gacccctcgg   1500

aagagattga gatcctcctg cggtacggcc agcacccgaa catcatcacc ctcaaggatg   1560

tctatgatga tggcaagttt gtgtacctgg taatggagct gatgcgtggt ggggagctcc   1620

tggaccgcat cctccggcag agatacttct cggagcgcga agccagtgac gtcctgtgca   1680

ccatcaccaa gaccatggac tacctccatt cccagggggt tgttcatcga gacctgaagc   1740

cgagtaacat cctgtacagg gatgagtcgg ggagcccaga atccatccga gtctgcgact   1800

tcggctttgc caagcagctg cgcgcgggga acgggctgct catgacaccc tgctacacgg   1860

ccaatttcgt ggccccggag gtcctgaagc gtcaaggcta tgatgcggcg tgtgacatct   1920

ggagtttggg gatcctgttg tacaccatgc tggcaggatt tacccctttt gcaaatgggc   1980

cagacgatac ccctgaggag attctggcgc ggatcggcag tgggaagtat gccctttctg   2040

ggggaaactg ggactcgata tctgacgcag ctaaagacgt cgtgtccaag atgctccacg   2100

tggaccctca tcagcgcctg acggcgatgc aagtgctcaa acacccgtgg gtggtcaaca   2160

gagagtacct gtccccaaac cagctcagcc gacaggacgt gcacctggtg aagggcgcga   2220

tggccgccac ctactttgct ctaaacagaa cacctcaggc cccgcggctg gagcccgtgc   2280

tgtcatccaa cctggctcag cgcagaggca tgaagagact cacgtccacg cggctgtagc   2340

gggtgggacc ctggccccag cgtcccctgc cagcatcctc gtgggctcac agaccccggc   2400

ctcggagccc gtctggcacc cagagtgacc acaagtccag cagggaggcg gcgcccgccc   2460

tcgccgtgtc cgtgttttct ttttcagccc cggagagggt cctgacctgg gggcttctcc   2520

aagcctcact gcgccagcct ccccgcccgc tctcttttct cccaagcgaa accaaatgcg   2580

ccccttcacc tcgcgtgccc gtgcgaggcc gggggcttct ttcagagccc gcgggtcctc   2640

tcatacatgg cttctgtttc tgccgagaga tctgttttcc aattatgaag ccggtcggtt   2700

tggtcagact cccgacaccc acgtcccagg tacccggtgg gaaagtggca gtgcgagggc   2760

gcagccattg gtggttgcag ggccccagag ggctggggtg acctggcatc ccggggctcc   2820

ccacgggctg gatgacgggg ttggcactgt ggcgtccagg aggagatgcc tggttctgcc   2880

caaaataatc caaagagccg tttcctcctc gcccttcagt ttttgcctga ggtgctgggt   2940

agcccatcct ttcctctgtc ccagattcaa atgaggagta agagcccaga cgagaggaag   3000

gcaggctgga tctttgcctt gagagctccg tgtcaccagg atggaagggg gtgcctctcg   3060

gaggagcctg tgtccacctc cagtctcggc tttccccggg gggccaagcg cactgggctg   3120

ccgtctgtcc ccagctcccg tggccacaca gctatctgga ggctttgcag ggagtcgtgg   3180

gttctcgcac ctgctcagcc ctgtgtcggc ttcctgtgtg ctcacctaaa gctgtggttt   3240

tgctgtgttc acttcgattt ttctggtctg tggagaaact gtgaattgga gaaatggagc   3300

tctgtggctt cccacccaaa ccttctcagt ccagctggag gctggaggga gacacaggcc   3360

ccacccagca gactgagggg cagaggcaca ggtgggaggg cagcggagat cagcgtggac   3420

aggagcgatg cactttgtag atgctgtggc tttgtgttgc gttttgtgtc tctgttgcac   3480

agatctgttt tttcacactg atccgtattc ccctgggtgt gcacacaggg cgggtgtggg   3540

gcatttaggc catgctgtgc tctacttcat tgagtaaaat cgagtgagag gttccgggca   3600

gcaggatcga cgcccagtcc agccggcaga gggaacacac gggtccttca ttgtcctgta   3660

agggtgttga agatgctccc tggcggcccc caagcagact agatgggagg aggcgccgct   3720

cagcccctca ccctgcatca ctgaagagcg gcgcctctgc agcaagcagg gcttcaggag   3780

gtgcccgctg gccacagcca ggttttccct aagaagatgt tattttgttg ggttttgttc   3840

cccctccatc tcgattctcg tacccaacta aaaaaaaaaa aataaagaaa aaatgtgctg   3900

cgttctgaaa aataactcct tagcttggtc tgattgtttt cagaccttaa aatataaact   3960

tgtttcacaa gctttaatcc atgtggattt tttttttctt agagaaccac aaaacataaa   4020

aggagcaagt cggactgaat acctgtttcc atagtgccca cagggtattc ctcacatttt   4080

ctccatagaa gatgcttttt cccaaggcta gaacgacttc caccatgatg aatttgcttt   4140

ttaggtctta attatttcac ttctttttag aaacttagga agaagtggat aatcctgagg   4200

tcacacaatc tgtcctccca gaaatgaaca aaagtcatca ccttttctgc ttgctacaca   4260

ggcaacgatt cccccatcag ctgcccggac cctttggcct ggcttggtgt gcaggcctgt   4320

ctgtttgctt aaagtcagtg ggttctggtg cagggagtga gaagtggggg aagtgaaagg   4380

gaaagcatcc gtgagaaagc ggccacggtt ttccctcctt gtgtgcccat ggggcaccag   4440

ctcatggtct ttttcagtca tcccagtttg tacagactta gcttctgaac tctaagaatg   4500

ccaaagggac cgacgagact ccccatcaca gcgagctctg tccttacatg tatttgatgt   4560

gcatcagcgg aggagaacac tggcttggcc ctgctccgct gagtgtctgt gaaatacctc   4620

tactttccct cccatatcca gaacaaaatg atacttgaca tccttccaca aaagtcagcc   4680

taaagaagtt atggtatcat atgttaaact aagctttcaa aaaccttagt gaaatagcaa   4740

gtgactgctt tcaagcagca gtcgacatgt aaatgaaggt gttcttagaa ttcgcatttt   4800

gccagctcag cgcacctcca caacgaatga aatgctccgt atgatttgca caaatgacat   4860

agacctcccc aaaagttaac tggctctcct tcctcacaca gttcatcata acccaacccc   4920

ccacccccgg gtcatgaaaa tcacagaact tataaacaca ttgaacccta gatctcaggc   4980

ttcctgacct accgccagtg gccccttgct ggccacccta tagggtcctc cttccctggc   5040

agccccccat gtgggagaaa tacctgattc tcccaatctg cagtgggaga gctttgctga   5100

attccatccc aaagtcaaac atgggcaaga ggtgaggatt tcacttttac cctcaagtcc   5160

gatttgtctg tgattttaaa ctaactgtgt atgtattgat gtttggaaga ttgtttgaat   5220

tttaaagtga taatagtact taatgttatc cagtattgtt cattaaatgg tgttatccta   5280

aagctgcact tgggattttt acctaacgct ttactgattc tctcaagcac atggcaaagt   5340

ttgatttgca ctccgttcat ttctgacacg ttttgctgcc tcctaccttt ctaagcgtca   5400

tgcaaattcg agaatggaga aggacgctgc cggtccctga gcggtgtgga gagggcggaa   5460

ggtggactcc agcgcagctt gaggggctga ggacggaggc tgcagcatct gtgtcgttct   5520

actgagcacg cttctctgcc tcgctcctga ctcagcactt tgttcactgg ctcagcagtt   5580

atgtttacac atcattttta tgttcctgct ttgtaattca tgtttgagat gggtggccac   5640

tgtacagata tttattacgc tttccagact ttctgaatag atttttttga ataaacatgg   5700

ttttatgaag tgtaatcttt ttctagccta acaat                              5735


<210>  1898
<211>  741
<212>  PRT
<213>  Homosapiens

<400>  1898

Met Pro Ile Ala Gln Leu Leu Glu Leu Trp Lys Lys Ile Glu Val Glu 
1               5                   10                  15      


Pro Met Glu Ile Glu Thr Thr Glu Glu Asp Leu Asn Leu Asp Val Glu 
            20                  25                  30          


Pro Thr Thr Glu Asp Thr Ala Glu Glu Glu Glu Gly Val Val Lys Glu 
        35                  40                  45              


Ile Asp Ile Ser His His Val Lys Glu Gly Phe Glu Lys Ala Asp Pro 
    50                  55                  60                  


Ser Gln Phe Glu Leu Leu Lys Val Leu Gly Gln Gly Ser Tyr Gly Lys 
65                  70                  75                  80  


Val Phe Leu Val Arg Lys Val Lys Gly Ser Asp Ala Gly Gln Leu Tyr 
                85                  90                  95      


Ala Met Lys Val Leu Lys Lys Ala Thr Leu Lys Val Arg Asp Arg Val 
            100                 105                 110         


Arg Ser Lys Met Glu Arg Asp Ile Leu Ala Glu Val Asn His Pro Phe 
        115                 120                 125             


Ile Val Lys Leu His Tyr Ala Phe Gln Thr Glu Gly Lys Leu Tyr Leu 
    130                 135                 140                 


Ile Leu Asp Phe Leu Arg Gly Gly Asp Leu Phe Thr Arg Leu Ser Lys 
145                 150                 155                 160 


Glu Val Met Phe Thr Glu Glu Asp Val Lys Phe Tyr Leu Ala Glu Leu 
                165                 170                 175     


Ala Leu Ala Leu Asp His Leu His Ser Leu Gly Ile Ile Tyr Arg Asp 
            180                 185                 190         


Leu Lys Pro Glu Asn Ile Leu Leu Asp Glu Glu Gly His Ile Lys Ile 
        195                 200                 205             


Thr Asp Phe Gly Leu Ser Lys Glu Ala Ile Asp His Asp Lys Arg Ala 
    210                 215                 220                 


Tyr Ser Phe Cys Gly Thr Ile Glu Tyr Met Ala Pro Glu Val Val Asn 
225                 230                 235                 240 


Arg Arg Gly His Thr Gln Ser Ala Asp Trp Trp Ser Phe Gly Val Leu 
                245                 250                 255     


Met Phe Glu Met Leu Thr Gly Ser Leu Pro Phe Gln Gly Lys Asp Arg 
            260                 265                 270         


Lys Glu Thr Met Ala Leu Ile Leu Lys Ala Lys Leu Gly Met Pro Gln 
        275                 280                 285             


Phe Leu Ser Gly Glu Ala Gln Ser Leu Leu Arg Ala Leu Phe Lys Arg 
    290                 295                 300                 


Asn Pro Cys Asn Arg Leu Gly Ala Gly Ile Asp Gly Val Glu Glu Ile 
305                 310                 315                 320 


Lys Arg His Pro Phe Phe Val Thr Ile Asp Trp Asn Thr Leu Tyr Arg 
                325                 330                 335     


Lys Glu Ile Lys Pro Pro Phe Lys Pro Ala Val Gly Arg Pro Glu Asp 
            340                 345                 350         


Thr Phe His Phe Asp Pro Glu Phe Thr Ala Arg Thr Pro Thr Asp Ser 
        355                 360                 365             


Pro Gly Val Pro Pro Ser Ala Asn Ala His His Leu Phe Arg Gly Phe 
    370                 375                 380                 


Ser Phe Val Ala Ser Ser Leu Ile Gln Glu Pro Ser Gln Gln Asp Leu 
385                 390                 395                 400 


His Lys Val Pro Val His Pro Ile Val Gln Gln Leu His Gly Asn Asn 
                405                 410                 415     


Ile His Phe Thr Asp Gly Tyr Glu Ile Lys Glu Asp Ile Gly Val Gly 
            420                 425                 430         


Ser Tyr Ser Val Cys Lys Arg Cys Val His Lys Ala Thr Asp Thr Glu 
        435                 440                 445             


Tyr Ala Val Lys Ile Ile Asp Lys Ser Lys Arg Asp Pro Ser Glu Glu 
    450                 455                 460                 


Ile Glu Ile Leu Leu Arg Tyr Gly Gln His Pro Asn Ile Ile Thr Leu 
465                 470                 475                 480 


Lys Asp Val Tyr Asp Asp Gly Lys Phe Val Tyr Leu Val Met Glu Leu 
                485                 490                 495     


Met Arg Gly Gly Glu Leu Leu Asp Arg Ile Leu Arg Gln Arg Tyr Phe 
            500                 505                 510         


Ser Glu Arg Glu Ala Ser Asp Val Leu Cys Thr Ile Thr Lys Thr Met 
        515                 520                 525             


Asp Tyr Leu His Ser Gln Gly Val Val His Arg Asp Leu Lys Pro Ser 
    530                 535                 540                 


Asn Ile Leu Tyr Arg Asp Glu Ser Gly Ser Pro Glu Ser Ile Arg Val 
545                 550                 555                 560 


Cys Asp Phe Gly Phe Ala Lys Gln Leu Arg Ala Gly Asn Gly Leu Leu 
                565                 570                 575     


Met Thr Pro Cys Tyr Thr Ala Asn Phe Val Ala Pro Glu Val Leu Lys 
            580                 585                 590         


Arg Gln Gly Tyr Asp Ala Ala Cys Asp Ile Trp Ser Leu Gly Ile Leu 
        595                 600                 605             


Leu Tyr Thr Met Leu Ala Gly Phe Thr Pro Phe Ala Asn Gly Pro Asp 
    610                 615                 620                 


Asp Thr Pro Glu Glu Ile Leu Ala Arg Ile Gly Ser Gly Lys Tyr Ala 
625                 630                 635                 640 


Leu Ser Gly Gly Asn Trp Asp Ser Ile Ser Asp Ala Ala Lys Asp Val 
                645                 650                 655     


Val Ser Lys Met Leu His Val Asp Pro His Gln Arg Leu Thr Ala Met 
            660                 665                 670         


Gln Val Leu Lys His Pro Trp Val Val Asn Arg Glu Tyr Leu Ser Pro 
        675                 680                 685             


Asn Gln Leu Ser Arg Gln Asp Val His Leu Val Lys Gly Ala Met Ala 
    690                 695                 700                 


Ala Thr Tyr Phe Ala Leu Asn Arg Thr Pro Gln Ala Pro Arg Leu Glu 
705                 710                 715                 720 


Pro Val Leu Ser Ser Asn Leu Ala Gln Arg Arg Gly Met Lys Arg Leu 
                725                 730                 735     


Thr Ser Thr Arg Leu 
            740     


<210>  1899
<211>  5817
<212>  DNA
<213>  Homosapiens

<400>  1899
gcggagaagg aggcggaggg agcgattgtg gccccggccg cggtggccgg cgcggcctgc     60

cctttgtgac cgcagctcgc gccccacgcc ccgcgcccat ggccgccgtg ccgggctccc    120

tggccacgcg tgcccgcccg cggacctgag ccccgcgcct gggatgccgg ggatgcgcgt    180

cccccggccc tgcggctgct ccgggctggg cgcggggcga tggacctgag catgaagaag    240

ttcgccgtgc gcaggttctt ctctgtgtac ctgcgcagga agtcgcgctc caagagctcc    300

agcctgagcc ggctcgagga agaaggcgtc gtgaaggaga tagacatcag ccatcatgtg    360

aaggagggct ttgagaaggc agatccttcc cagtttgagc tgctgaaggt tttaggacaa    420

ggatcctatg gaaaggtgtt cctggtgagg aaggtgaagg ggtccgacgc tgggcagctc    480

tacgccatga aggtccttaa gaaagccacc ctaaaagttc gggaccgagt gagatcgaag    540

atggagagag acatcttggc agaagtgaat caccccttca ttgtgaagct tcattatgcc    600

tttcagacgg aaggaaagct ctacctgatc ctggacttcc tgcggggagg ggacctcttc    660

acccggctct ccaaagaggt catgttcacg gaggaggatg tcaagttcta cctggctgag    720

ctggccttgg ctttagacca tctccacagc ctggggatca tctacagaga tctgaagcct    780

gagaacatcc tcctggatga agaggggcac attaagatca cagatttcgg cctgagtaag    840

gaggccattg accacgacaa gagagcgtac tccttctgcg ggacgatcga gtacatggcg    900

cccgaggtgg tgaaccggcg aggacacacg cagagtgccg actggtggtc cttcggcgtg    960

ctcatgtttg agatgctcac ggggtccctg ccgttccagg ggaaggacag gaaggagacc   1020

atggctctca tcctcaaagc caagctgggg atgccgcagt tcctcagtgg ggaggcacag   1080

agtttgctgc gagctctctt caaacggaac ccctgcaacc ggctgggtgc tggcattgac   1140

ggagtggagg aaattaagcg ccatcccttc tttgtgacca tagactggaa cacgctgtac   1200

cggaaggaga tcaagccacc gttcaaacca gcagtgggca ggcctgagga caccttccac   1260

tttgaccccg agttcacagc gcggacgccc acagactctc ctggcgtccc cccgagtgca   1320

aacgctcatc acctgtttag aggattcagc tttgtggcct caagcctgat ccaggagccc   1380

tcacagcaag atctgcacaa agtcccagtt cacccaatcg tgcagcagtt acacgggaac   1440

aacatccact tcaccgatgg ctacgagatc aaggaggaca tcggggtggg ctcctactca   1500

gtgtgcaagc gatgtgtgca taaagccaca gacaccgagt atgccgtgaa gatcattgat   1560

aagagcaaga gagacccctc ggaagagatt gagatcctcc tgcggtacgg ccagcacccg   1620

aacatcatca ccctcaagga tgtctatgat gatggcaagt ttgtgtacct ggtaatggag   1680

ctgatgcgtg gtggggagct cctggaccgc atcctccggc agagatactt ctcggagcgc   1740

gaagccagtg acgtcctgtg caccatcacc aagaccatgg actacctcca ttcccagggg   1800

gttgttcatc gagacctgaa gccgagtaac atcctgtaca gggatgagtc ggggagccca   1860

gaatccatcc gagtctgcga cttcggcttt gccaagcagc tgcgcgcggg gaacgggctg   1920

ctcatgacac cctgctacac ggccaatttc gtggccccgg aggtcctgaa gcgtcaaggc   1980

tatgatgcgg cgtgtgacat ctggagtttg gggatcctgt tgtacaccat gctggcagga   2040

tttacccctt ttgcaaatgg gccagacgat acccctgagg agattctggc gcggatcggc   2100

agtgggaagt atgccctttc tgggggaaac tgggactcga tatctgacgc agctaaagac   2160

gtcgtgtcca agatgctcca cgtggaccct catcagcgcc tgacggcgat gcaagtgctc   2220

aaacacccgt gggtggtcaa cagagagtac ctgtccccaa accagctcag ccgacaggac   2280

gtgcacctgg tgaagggcgc gatggccgcc acctactttg ctctaaacag aacacctcag   2340

gccccgcggc tggagcccgt gctgtcatcc aacctggctc agcgcagagg catgaagaga   2400

ctcacgtcca cgcggctgta gcgggtggga ccctggcccc agcgtcccct gccagcatcc   2460

tcgtgggctc acagaccccg gcctcggagc ccgtctggca cccagagtga ccacaagtcc   2520

agcagggagg cggcgcccgc cctcgccgtg tccgtgtttt ctttttcagc cccggagagg   2580

gtcctgacct gggggcttct ccaagcctca ctgcgccagc ctccccgccc gctctctttt   2640

ctcccaagcg aaaccaaatg cgccccttca cctcgcgtgc ccgtgcgagg ccgggggctt   2700

ctttcagagc ccgcgggtcc tctcatacat ggcttctgtt tctgccgaga gatctgtttt   2760

ccaattatga agccggtcgg tttggtcaga ctcccgacac ccacgtccca ggtacccggt   2820

gggaaagtgg cagtgcgagg gcgcagccat tggtggttgc agggccccag agggctgggg   2880

tgacctggca tcccggggct ccccacgggc tggatgacgg ggttggcact gtggcgtcca   2940

ggaggagatg cctggttctg cccaaaataa tccaaagagc cgtttcctcc tcgcccttca   3000

gtttttgcct gaggtgctgg gtagcccatc ctttcctctg tcccagattc aaatgaggag   3060

taagagccca gacgagagga aggcaggctg gatctttgcc ttgagagctc cgtgtcacca   3120

ggatggaagg gggtgcctct cggaggagcc tgtgtccacc tccagtctcg gctttccccg   3180

gggggccaag cgcactgggc tgccgtctgt ccccagctcc cgtggccaca cagctatctg   3240

gaggctttgc agggagtcgt gggttctcgc acctgctcag ccctgtgtcg gcttcctgtg   3300

tgctcaccta aagctgtggt tttgctgtgt tcacttcgat ttttctggtc tgtggagaaa   3360

ctgtgaattg gagaaatgga gctctgtggc ttcccaccca aaccttctca gtccagctgg   3420

aggctggagg gagacacagg ccccacccag cagactgagg ggcagaggca caggtgggag   3480

ggcagcggag atcagcgtgg acaggagcga tgcactttgt agatgctgtg gctttgtgtt   3540

gcgttttgtg tctctgttgc acagatctgt tttttcacac tgatccgtat tcccctgggt   3600

gtgcacacag ggcgggtgtg gggcatttag gccatgctgt gctctacttc attgagtaaa   3660

atcgagtgag aggttccggg cagcaggatc gacgcccagt ccagccggca gagggaacac   3720

acgggtcctt cattgtcctg taagggtgtt gaagatgctc cctggcggcc cccaagcaga   3780

ctagatggga ggaggcgccg ctcagcccct caccctgcat cactgaagag cggcgcctct   3840

gcagcaagca gggcttcagg aggtgcccgc tggccacagc caggttttcc ctaagaagat   3900

gttattttgt tgggttttgt tccccctcca tctcgattct cgtacccaac taaaaaaaaa   3960

aaaataaaga aaaaatgtgc tgcgttctga aaaataactc cttagcttgg tctgattgtt   4020

ttcagacctt aaaatataaa cttgtttcac aagctttaat ccatgtggat tttttttttc   4080

ttagagaacc acaaaacata aaaggagcaa gtcggactga atacctgttt ccatagtgcc   4140

cacagggtat tcctcacatt ttctccatag aagatgcttt ttcccaaggc tagaacgact   4200

tccaccatga tgaatttgct ttttaggtct taattatttc acttcttttt agaaacttag   4260

gaagaagtgg ataatcctga ggtcacacaa tctgtcctcc cagaaatgaa caaaagtcat   4320

caccttttct gcttgctaca caggcaacga ttcccccatc agctgcccgg accctttggc   4380

ctggcttggt gtgcaggcct gtctgtttgc ttaaagtcag tgggttctgg tgcagggagt   4440

gagaagtggg ggaagtgaaa gggaaagcat ccgtgagaaa gcggccacgg ttttccctcc   4500

ttgtgtgccc atggggcacc agctcatggt ctttttcagt catcccagtt tgtacagact   4560

tagcttctga actctaagaa tgccaaaggg accgacgaga ctccccatca cagcgagctc   4620

tgtccttaca tgtatttgat gtgcatcagc ggaggagaac actggcttgg ccctgctccg   4680

ctgagtgtct gtgaaatacc tctactttcc ctcccatatc cagaacaaaa tgatacttga   4740

catccttcca caaaagtcag cctaaagaag ttatggtatc atatgttaaa ctaagctttc   4800

aaaaacctta gtgaaatagc aagtgactgc tttcaagcag cagtcgacat gtaaatgaag   4860

gtgttcttag aattcgcatt ttgccagctc agcgcacctc cacaacgaat gaaatgctcc   4920

gtatgatttg cacaaatgac atagacctcc ccaaaagtta actggctctc cttcctcaca   4980

cagttcatca taacccaacc ccccaccccc gggtcatgaa aatcacagaa cttataaaca   5040

cattgaaccc tagatctcag gcttcctgac ctaccgccag tggccccttg ctggccaccc   5100

tatagggtcc tccttccctg gcagcccccc atgtgggaga aatacctgat tctcccaatc   5160

tgcagtggga gagctttgct gaattccatc ccaaagtcaa acatgggcaa gaggtgagga   5220

tttcactttt accctcaagt ccgatttgtc tgtgatttta aactaactgt gtatgtattg   5280

atgtttggaa gattgtttga attttaaagt gataatagta cttaatgtta tccagtattg   5340

ttcattaaat ggtgttatcc taaagctgca cttgggattt ttacctaacg ctttactgat   5400

tctctcaagc acatggcaaa gtttgatttg cactccgttc atttctgaca cgttttgctg   5460

cctcctacct ttctaagcgt catgcaaatt cgagaatgga gaaggacgct gccggtccct   5520

gagcggtgtg gagagggcgg aaggtggact ccagcgcagc ttgaggggct gaggacggag   5580

gctgcagcat ctgtgtcgtt ctactgagca cgcttctctg cctcgctcct gactcagcac   5640

tttgttcact ggctcagcag ttatgtttac acatcatttt tatgttcctg ctttgtaatt   5700

catgtttgag atgggtggcc actgtacaga tatttattac gctttccaga ctttctgaat   5760

agattttttt gaataaacat ggttttatga agtgtaatct ttttctagcc taacaat      5817


<210>  1900
<211>  733
<212>  PRT
<213>  Homosapiens

<400>  1900

Met Asp Leu Ser Met Lys Lys Phe Ala Val Arg Arg Phe Phe Ser Val 
1               5                   10                  15      


Tyr Leu Arg Arg Lys Ser Arg Ser Lys Ser Ser Ser Leu Ser Arg Leu 
            20                  25                  30          


Glu Glu Glu Gly Val Val Lys Glu Ile Asp Ile Ser His His Val Lys 
        35                  40                  45              


Glu Gly Phe Glu Lys Ala Asp Pro Ser Gln Phe Glu Leu Leu Lys Val 
    50                  55                  60                  


Leu Gly Gln Gly Ser Tyr Gly Lys Val Phe Leu Val Arg Lys Val Lys 
65                  70                  75                  80  


Gly Ser Asp Ala Gly Gln Leu Tyr Ala Met Lys Val Leu Lys Lys Ala 
                85                  90                  95      


Thr Leu Lys Val Arg Asp Arg Val Arg Ser Lys Met Glu Arg Asp Ile 
            100                 105                 110         


Leu Ala Glu Val Asn His Pro Phe Ile Val Lys Leu His Tyr Ala Phe 
        115                 120                 125             


Gln Thr Glu Gly Lys Leu Tyr Leu Ile Leu Asp Phe Leu Arg Gly Gly 
    130                 135                 140                 


Asp Leu Phe Thr Arg Leu Ser Lys Glu Val Met Phe Thr Glu Glu Asp 
145                 150                 155                 160 


Val Lys Phe Tyr Leu Ala Glu Leu Ala Leu Ala Leu Asp His Leu His 
                165                 170                 175     


Ser Leu Gly Ile Ile Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu 
            180                 185                 190         


Asp Glu Glu Gly His Ile Lys Ile Thr Asp Phe Gly Leu Ser Lys Glu 
        195                 200                 205             


Ala Ile Asp His Asp Lys Arg Ala Tyr Ser Phe Cys Gly Thr Ile Glu 
    210                 215                 220                 


Tyr Met Ala Pro Glu Val Val Asn Arg Arg Gly His Thr Gln Ser Ala 
225                 230                 235                 240 


Asp Trp Trp Ser Phe Gly Val Leu Met Phe Glu Met Leu Thr Gly Ser 
                245                 250                 255     


Leu Pro Phe Gln Gly Lys Asp Arg Lys Glu Thr Met Ala Leu Ile Leu 
            260                 265                 270         


Lys Ala Lys Leu Gly Met Pro Gln Phe Leu Ser Gly Glu Ala Gln Ser 
        275                 280                 285             


Leu Leu Arg Ala Leu Phe Lys Arg Asn Pro Cys Asn Arg Leu Gly Ala 
    290                 295                 300                 


Gly Ile Asp Gly Val Glu Glu Ile Lys Arg His Pro Phe Phe Val Thr 
305                 310                 315                 320 


Ile Asp Trp Asn Thr Leu Tyr Arg Lys Glu Ile Lys Pro Pro Phe Lys 
                325                 330                 335     


Pro Ala Val Gly Arg Pro Glu Asp Thr Phe His Phe Asp Pro Glu Phe 
            340                 345                 350         


Thr Ala Arg Thr Pro Thr Asp Ser Pro Gly Val Pro Pro Ser Ala Asn 
        355                 360                 365             


Ala His His Leu Phe Arg Gly Phe Ser Phe Val Ala Ser Ser Leu Ile 
    370                 375                 380                 


Gln Glu Pro Ser Gln Gln Asp Leu His Lys Val Pro Val His Pro Ile 
385                 390                 395                 400 


Val Gln Gln Leu His Gly Asn Asn Ile His Phe Thr Asp Gly Tyr Glu 
                405                 410                 415     


Ile Lys Glu Asp Ile Gly Val Gly Ser Tyr Ser Val Cys Lys Arg Cys 
            420                 425                 430         


Val His Lys Ala Thr Asp Thr Glu Tyr Ala Val Lys Ile Ile Asp Lys 
        435                 440                 445             


Ser Lys Arg Asp Pro Ser Glu Glu Ile Glu Ile Leu Leu Arg Tyr Gly 
    450                 455                 460                 


Gln His Pro Asn Ile Ile Thr Leu Lys Asp Val Tyr Asp Asp Gly Lys 
465                 470                 475                 480 


Phe Val Tyr Leu Val Met Glu Leu Met Arg Gly Gly Glu Leu Leu Asp 
                485                 490                 495     


Arg Ile Leu Arg Gln Arg Tyr Phe Ser Glu Arg Glu Ala Ser Asp Val 
            500                 505                 510         


Leu Cys Thr Ile Thr Lys Thr Met Asp Tyr Leu His Ser Gln Gly Val 
        515                 520                 525             


Val His Arg Asp Leu Lys Pro Ser Asn Ile Leu Tyr Arg Asp Glu Ser 
    530                 535                 540                 


Gly Ser Pro Glu Ser Ile Arg Val Cys Asp Phe Gly Phe Ala Lys Gln 
545                 550                 555                 560 


Leu Arg Ala Gly Asn Gly Leu Leu Met Thr Pro Cys Tyr Thr Ala Asn 
                565                 570                 575     


Phe Val Ala Pro Glu Val Leu Lys Arg Gln Gly Tyr Asp Ala Ala Cys 
            580                 585                 590         


Asp Ile Trp Ser Leu Gly Ile Leu Leu Tyr Thr Met Leu Ala Gly Phe 
        595                 600                 605             


Thr Pro Phe Ala Asn Gly Pro Asp Asp Thr Pro Glu Glu Ile Leu Ala 
    610                 615                 620                 


Arg Ile Gly Ser Gly Lys Tyr Ala Leu Ser Gly Gly Asn Trp Asp Ser 
625                 630                 635                 640 


Ile Ser Asp Ala Ala Lys Asp Val Val Ser Lys Met Leu His Val Asp 
                645                 650                 655     


Pro His Gln Arg Leu Thr Ala Met Gln Val Leu Lys His Pro Trp Val 
            660                 665                 670         


Val Asn Arg Glu Tyr Leu Ser Pro Asn Gln Leu Ser Arg Gln Asp Val 
        675                 680                 685             


His Leu Val Lys Gly Ala Met Ala Ala Thr Tyr Phe Ala Leu Asn Arg 
    690                 695                 700                 


Thr Pro Gln Ala Pro Arg Leu Glu Pro Val Leu Ser Ser Asn Leu Ala 
705                 710                 715                 720 


Gln Arg Arg Gly Met Lys Arg Leu Thr Ser Thr Arg Leu 
                725                 730             


<210>  1901
<211>  1932
<212>  DNA
<213>  Homosapiens

<400>  1901
gacccgctcg ctcgctcgcc agccgtcccc gcgccccgcg tccccgcgcc agccgcctcc     60

tggcctcggg cgccgcgcat ccaggaagga agcagccacc ctcgccatgg cctccccgcc    120

cgcctgcccc tcggaggagg acgagagcct gaagggctgt gagctgtacg tgcagctgca    180

cgggatccag caggtcctca aagactgtat cgtccacctc tgcatctcca agcccgaacg    240

ccccatgaag ttcctccggg agcacttcga gaagctggag aaggaagaaa acaggcagat    300

tttggcgcgg caaaagtcaa actcacagtc ggactcccat gatgaggagg tgtcgcccac    360

ccccccgaac cctgtggtga aggcccgccg ccggcgagga ggcgtgagtg ccgaggtgta    420

caccgaggag gacgccgtgt cctacgtcag gaaggtgatt cccaaggact acaaaaccat    480

gactgcgctg gccaaggcca tctccaagaa cgtgctcttc gctcacctgg atgacaacga    540

gaggagtgac atattcgatg ccatgttccc tgtcactcac atcgctgggg agactgttat    600

acagcaaggg aatgaaggag acaacttcta tgtcgttgat caaggggaag tggatgtgta    660

cgtgaacgga gagtgggtga ccaacatcag cgagggaggc agcttcgggg agctggcgct    720

catctacggc acccccaggg ctgcgaccgt gaaagccaag acggacctca agctctgggg    780

gatcgaccgg gacagctacc ggcgcatcct tatgggcagc acgctgagga aacgcaagat    840

gtacgaggag ttcctcagca aggtctccat cctagagtcc ctggagaagt gggagcgtct    900

gaccgtggcg gatgcgctgg agcccgtcca gtttgaagat ggagagaaaa ttgtggtcca    960

gggagagcct ggggacgact tttacatcat cacggagggc accgcgtccg tgctgcagcg   1020

ccggtccccc aatgaggagt acgtggaggt ggggcgcctg ggaccctctg actacttcgg   1080

ggagattgca ctgctgctga accggccccg ggcggccact gtcgtggccc gggggcccct   1140

caagtgtgtg aagctggacc ggccccgctt cgagcgtgtg ctggggccct gctctgagat   1200

cctcaagagg aacattcagc gttacaacag cttcatctcc ctcaccgtct gagcacagct   1260

cccgccctgc agccccagct ccccagtgtg gtggccgtgc cctgctcgtc tgtgtcgggg   1320

gcccgggagc cgctgtgtga ggtgtgggcc gggtggggct gggtcccggc agcgtgagga   1380

ctgccccttc cccggactca ctttttggaa taaatgatca ccttgtgcat ttccaaatca   1440

aaggacaagc ggacaaaatg catcccaaga tcaaggaagg gacaggccag cttcctcccc   1500

acacgcctcc ccggctgcct ctgtgggctt ctcctggggg gcccacccca cccctgccag   1560

tctcctggag atgcttgagg atcggtcctc cccagaacca ggccaggacg ttgcccctgg   1620

ggcctggtga ccctgtgagg tcaggtcccc cagattgagg tctgagtgtg ggcaagtgtg   1680

tcaaaagggg ctgcccccca ggggagatga ggctgagagc agggagttga ggccgaagaa   1740

gtcaaggccc ctcccgcaaa tgtgtacccc tgcccgcgcc actgcacccc gccgcacccc   1800

cacctccccc gggggccctg ctgcggatgc cggagtggga gagtctctga gctgtgagat   1860

tgatcttgcc cctaattgga gaggaagccg ggcgccaaga cacacggggc tcctgccttg   1920

ggagccaggg cc                                                       1932


<210>  1902
<211>  381
<212>  PRT
<213>  Homosapiens

<400>  1902

Met Ala Ser Pro Pro Ala Cys Pro Ser Glu Glu Asp Glu Ser Leu Lys 
1               5                   10                  15      


Gly Cys Glu Leu Tyr Val Gln Leu His Gly Ile Gln Gln Val Leu Lys 
            20                  25                  30          


Asp Cys Ile Val His Leu Cys Ile Ser Lys Pro Glu Arg Pro Met Lys 
        35                  40                  45              


Phe Leu Arg Glu His Phe Glu Lys Leu Glu Lys Glu Glu Asn Arg Gln 
    50                  55                  60                  


Ile Leu Ala Arg Gln Lys Ser Asn Ser Gln Ser Asp Ser His Asp Glu 
65                  70                  75                  80  


Glu Val Ser Pro Thr Pro Pro Asn Pro Val Val Lys Ala Arg Arg Arg 
                85                  90                  95      


Arg Gly Gly Val Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Val Ser 
            100                 105                 110         


Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Thr Ala Leu 
        115                 120                 125             


Ala Lys Ala Ile Ser Lys Asn Val Leu Phe Ala His Leu Asp Asp Asn 
    130                 135                 140                 


Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Pro Val Thr His Ile Ala 
145                 150                 155                 160 


Gly Glu Thr Val Ile Gln Gln Gly Asn Glu Gly Asp Asn Phe Tyr Val 
                165                 170                 175     


Val Asp Gln Gly Glu Val Asp Val Tyr Val Asn Gly Glu Trp Val Thr 
            180                 185                 190         


Asn Ile Ser Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly 
        195                 200                 205             


Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asp Leu Lys Leu Trp 
    210                 215                 220                 


Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu 
225                 230                 235                 240 


Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu 
                245                 250                 255     


Glu Ser Leu Glu Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu 
            260                 265                 270         


Pro Val Gln Phe Glu Asp Gly Glu Lys Ile Val Val Gln Gly Glu Pro 
        275                 280                 285             


Gly Asp Asp Phe Tyr Ile Ile Thr Glu Gly Thr Ala Ser Val Leu Gln 
    290                 295                 300                 


Arg Arg Ser Pro Asn Glu Glu Tyr Val Glu Val Gly Arg Leu Gly Pro 
305                 310                 315                 320 


Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Leu Asn Arg Pro Arg Ala 
                325                 330                 335     


Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg 
            340                 345                 350         


Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Glu Ile Leu Lys Arg 
        355                 360                 365             


Asn Ile Gln Arg Tyr Asn Ser Phe Ile Ser Leu Thr Val 
    370                 375                 380     


<210>  1903
<211>  3507
<212>  DNA
<213>  Homosapiens

<400>  1903
tggccggcga cgcgggcaag atggcggcgc tgggggtggc ggaggccgtg gcggccccac     60

acccggctga gggggccgag acggctgagg cggtggagct gagccgcgcc ctgagccgcc    120

tgctgccggg gctggaggcc gacagcaagc cgggccggcg gcgcgccttg gaggccctgc    180

ggcgcgcgct ggaggagcca ggccctgccg ccgaccccac cgctttccag ggcccctggg    240

cgcgcctact gctgccgcgc ttgctgcgct gcctgagcga ccccgccgag ggctgccgcg    300

cgctggcagt gcacctgctg gatctgggcc tgcgccgcgc cgcgcggcca cgcgatgccc    360

tgccgcgcct gctgcccgcg ctcgccgcgc gcttggccgg ccacgtgccc gcgcgccgcc    420

cgcccgaggc ctgtgaggag ctgcgcctgg cgcttgtgca gctgctgggc ctggccgtgg    480

acctgtgcgg cgccgcgctc gcgccccacc tggacgacgc tctgcgcgcg ctgcgctgct    540

ccctgctcga ccccttcgcc gccgtgcgcc gcgagagctg cagctgcgcc gccgccctgg    600

cgcaggccac gccagaccac ttccacatgc agtcggagtc tctgatcggg cccctgatgc    660

agaccatctc ccaccagcac tggaaggtcc gtgtggccgc cattgaagcc acaggcgcag    720

tgatccattt tggcaacggg aagtccgtgg acgacgtgct ttcccatttt gctcagcgac    780

tgtttgatga cgtcccgcag gtccggcggg cggtggcctc cgtggtgggc ggctggctgc    840

tgtgtctgcg tgaccgttac tccttcttcc acaagctcat ccctctgctg ctcagtagcc    900

tcaacgacga ggtgcctgag gtcaggcagc tggctgccag cctctgggag gacgttggcc    960

tgcagtggca gaaggagaat gaggaggacc tgaaggacaa gctggacttt gcccctccca   1020

ccccacccca ttaccctcca catgagcgcc gccctgtgct gggctgccgg gagctcgtct   1080

tcaggaacct ctccaagatc ctccctgccc tgtgccacga catcaccgac tgggtggtgg   1140

ggacccgagt gaagtcggca cagctgctcc cagtgctgct gctgcatgcc gaggaccacg   1200

ccacgcagca cctggaggtc gtcctccgga ccctgttcca ggcctgcacc gacgaggagg   1260

cagccgtggt ccaaagttgt accagatctg cagagctcgt cgggacgttt gtcagccctg   1320

aggtgtttct gaagctgatc ttatcgacgc tgaagaagac gccctctgcc tccggcctca   1380

tggtgctggc ctccgccatg cggggttgcc cccgagaagc cctccagccg cacctggcag   1440

ccatcgccac agagctggca caggcccaca tctgccaggc atctgaaaac gacctctacc   1500

tggagcgcct gctgctgtgt gtgcaggctc tggtgtctgt gtgtcatgag gactgtggcg   1560

tggccagcct gcagctcttg gacgtgctgc tgacaatagt ggccctcgca ggtgctaccg   1620

gcctgaggga caaggcacag gagacgatgg actcactggc catggtggag ggtgtcagca   1680

gctgccagga cctctaccgc aagcacattg gtcccctcct ggagcgggtg accgcgtcgc   1740

accttgactg gaccgcacac tcgccggagc tcctgcagtt cagtgtcatc gtcgcacagt   1800

caggccctgc cctgggagaa gccctgccac acgtcgtgcc cacgctgagg gcctgtctgc   1860

agccctccca agacccgcag atgcgcctga agctgttctc catcctgtcc accgtgctgc   1920

tcagagccac ggacaccatc aactcccagg ggcagtttcc cagctacctc gagacggtga   1980

caaaggacat cctggccccc aatctgcagt ggcatgcggg gaggacagcc gcggccatcc   2040

gcacggctgc cgtgtcctgc ctctgggcgc tcaccagcag cgaggtcctg tcggcagagc   2100

agatacggga cgtgcaggaa acactgatgc cccaggtcct gaccaccctg gaggaggatt   2160

cgaagatgac gcgactgatc tcatgccgta ttatcaacac gttcttaaaa acctcgggcg   2220

gcatgacgga tccagagaaa ctcatcagga tttatcctga actcttaaaa cgcctagatg   2280

acgtgtccaa cgatgtgagg atggcagccg cctccacctt ggtcacctgg ctgcagtgtg   2340

tcaagggtgc caacgcaaaa tcctactatc agagcagtgt ccagtacctg taccgagagt   2400

tgctggttca ccttgacgat ccagagaggg ccatccagga tgcaatttta gaggtcctca   2460

aagagggcag cgggctgttc ccagatctcc tggtgaggga gacggaggcc gtcatccaca   2520

agcaccgctc ggccacctac tgcgagcagc tcctgcagca tgtgcaggcc gtgccagcca   2580

cacagtgacc acgctggttt cagccacggc acacccttgt ccccacctga gccagagttt   2640

gtggcattta aatctcataa acaaggcacc tctgtgccag cagtgagact gtgacagcaa   2700

gaatgtactc ctcaggacac ctgcccgctc tttccctgga ataacagcct ctgagtggat   2760

tctgcatgtt atgtgatttg ttctgttcat cgagagggct cccaaacatc tgcagctgat   2820

ttgaaattaa aagtaagtcg cagccgctcc tcccgcagcc acttcagcag catcttagat   2880

tttaagcctc acgtgcgcag ctggttcatg aactattggc tgcatcctgc ttaggtgccc   2940

accaagaagg tttttaccta cttaacaaaa aagaaagaag ccaaagtgat tagaaagaaa   3000

tgaaatctct ttttgggttc tgtctactga aatttaatat ctcagtgaac agactaaaag   3060

gaatttagaa tcctaacaac ttaccagatt tctcctgttt taaatatact gggactttaa   3120

aggttatatg tccggtcacc gtatgtttta agtcggtgtt aatgctaaca gtgttgaaaa   3180

caatatttca tgagatctaa ttgtggttgc ccctataggt agcaggaaag taaagttgca   3240

tttccctctc gcacattcta cacccaagtg cctaaaagat ctcattgtaa gtgggtagtg   3300

ttaccggaag ccattgtgtt cacacggggg aaatgccgta tatatttttc aacaaatatt   3360

aacgtttata ctttcatgtt tgaaaattta attaaaaata tttgttttaa aaaaaaaaaa   3420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3480

aaaaaaaaaa aaaaaaaaaa aaaaaaa                                       3507


<210>  1904
<211>  855
<212>  PRT
<213>  Homosapiens

<400>  1904

Met Ala Ala Leu Gly Val Ala Glu Ala Val Ala Ala Pro His Pro Ala 
1               5                   10                  15      


Glu Gly Ala Glu Thr Ala Glu Ala Val Glu Leu Ser Arg Ala Leu Ser 
            20                  25                  30          


Arg Leu Leu Pro Gly Leu Glu Ala Asp Ser Lys Pro Gly Arg Arg Arg 
        35                  40                  45              


Ala Leu Glu Ala Leu Arg Arg Ala Leu Glu Glu Pro Gly Pro Ala Ala 
    50                  55                  60                  


Asp Pro Thr Ala Phe Gln Gly Pro Trp Ala Arg Leu Leu Leu Pro Arg 
65                  70                  75                  80  


Leu Leu Arg Cys Leu Ser Asp Pro Ala Glu Gly Cys Arg Ala Leu Ala 
                85                  90                  95      


Val His Leu Leu Asp Leu Gly Leu Arg Arg Ala Ala Arg Pro Arg Asp 
            100                 105                 110         


Ala Leu Pro Arg Leu Leu Pro Ala Leu Ala Ala Arg Leu Ala Gly His 
        115                 120                 125             


Val Pro Ala Arg Arg Pro Pro Glu Ala Cys Glu Glu Leu Arg Leu Ala 
    130                 135                 140                 


Leu Val Gln Leu Leu Gly Leu Ala Val Asp Leu Cys Gly Ala Ala Leu 
145                 150                 155                 160 


Ala Pro His Leu Asp Asp Ala Leu Arg Ala Leu Arg Cys Ser Leu Leu 
                165                 170                 175     


Asp Pro Phe Ala Ala Val Arg Arg Glu Ser Cys Ser Cys Ala Ala Ala 
            180                 185                 190         


Leu Ala Gln Ala Thr Pro Asp His Phe His Met Gln Ser Glu Ser Leu 
        195                 200                 205             


Ile Gly Pro Leu Met Gln Thr Ile Ser His Gln His Trp Lys Val Arg 
    210                 215                 220                 


Val Ala Ala Ile Glu Ala Thr Gly Ala Val Ile His Phe Gly Asn Gly 
225                 230                 235                 240 


Lys Ser Val Asp Asp Val Leu Ser His Phe Ala Gln Arg Leu Phe Asp 
                245                 250                 255     


Asp Val Pro Gln Val Arg Arg Ala Val Ala Ser Val Val Gly Gly Trp 
            260                 265                 270         


Leu Leu Cys Leu Arg Asp Arg Tyr Ser Phe Phe His Lys Leu Ile Pro 
        275                 280                 285             


Leu Leu Leu Ser Ser Leu Asn Asp Glu Val Pro Glu Val Arg Gln Leu 
    290                 295                 300                 


Ala Ala Ser Leu Trp Glu Asp Val Gly Leu Gln Trp Gln Lys Glu Asn 
305                 310                 315                 320 


Glu Glu Asp Leu Lys Asp Lys Leu Asp Phe Ala Pro Pro Thr Pro Pro 
                325                 330                 335     


His Tyr Pro Pro His Glu Arg Arg Pro Val Leu Gly Cys Arg Glu Leu 
            340                 345                 350         


Val Phe Arg Asn Leu Ser Lys Ile Leu Pro Ala Leu Cys His Asp Ile 
        355                 360                 365             


Thr Asp Trp Val Val Gly Thr Arg Val Lys Ser Ala Gln Leu Leu Pro 
    370                 375                 380                 


Val Leu Leu Leu His Ala Glu Asp His Ala Thr Gln His Leu Glu Val 
385                 390                 395                 400 


Val Leu Arg Thr Leu Phe Gln Ala Cys Thr Asp Glu Glu Ala Ala Val 
                405                 410                 415     


Val Gln Ser Cys Thr Arg Ser Ala Glu Leu Val Gly Thr Phe Val Ser 
            420                 425                 430         


Pro Glu Val Phe Leu Lys Leu Ile Leu Ser Thr Leu Lys Lys Thr Pro 
        435                 440                 445             


Ser Ala Ser Gly Leu Met Val Leu Ala Ser Ala Met Arg Gly Cys Pro 
    450                 455                 460                 


Arg Glu Ala Leu Gln Pro His Leu Ala Ala Ile Ala Thr Glu Leu Ala 
465                 470                 475                 480 


Gln Ala His Ile Cys Gln Ala Ser Glu Asn Asp Leu Tyr Leu Glu Arg 
                485                 490                 495     


Leu Leu Leu Cys Val Gln Ala Leu Val Ser Val Cys His Glu Asp Cys 
            500                 505                 510         


Gly Val Ala Ser Leu Gln Leu Leu Asp Val Leu Leu Thr Ile Val Ala 
        515                 520                 525             


Leu Ala Gly Ala Thr Gly Leu Arg Asp Lys Ala Gln Glu Thr Met Asp 
    530                 535                 540                 


Ser Leu Ala Met Val Glu Gly Val Ser Ser Cys Gln Asp Leu Tyr Arg 
545                 550                 555                 560 


Lys His Ile Gly Pro Leu Leu Glu Arg Val Thr Ala Ser His Leu Asp 
                565                 570                 575     


Trp Thr Ala His Ser Pro Glu Leu Leu Gln Phe Ser Val Ile Val Ala 
            580                 585                 590         


Gln Ser Gly Pro Ala Leu Gly Glu Ala Leu Pro His Val Val Pro Thr 
        595                 600                 605             


Leu Arg Ala Cys Leu Gln Pro Ser Gln Asp Pro Gln Met Arg Leu Lys 
    610                 615                 620                 


Leu Phe Ser Ile Leu Ser Thr Val Leu Leu Arg Ala Thr Asp Thr Ile 
625                 630                 635                 640 


Asn Ser Gln Gly Gln Phe Pro Ser Tyr Leu Glu Thr Val Thr Lys Asp 
                645                 650                 655     


Ile Leu Ala Pro Asn Leu Gln Trp His Ala Gly Arg Thr Ala Ala Ala 
            660                 665                 670         


Ile Arg Thr Ala Ala Val Ser Cys Leu Trp Ala Leu Thr Ser Ser Glu 
        675                 680                 685             


Val Leu Ser Ala Glu Gln Ile Arg Asp Val Gln Glu Thr Leu Met Pro 
    690                 695                 700                 


Gln Val Leu Thr Thr Leu Glu Glu Asp Ser Lys Met Thr Arg Leu Ile 
705                 710                 715                 720 


Ser Cys Arg Ile Ile Asn Thr Phe Leu Lys Thr Ser Gly Gly Met Thr 
                725                 730                 735     


Asp Pro Glu Lys Leu Ile Arg Ile Tyr Pro Glu Leu Leu Lys Arg Leu 
            740                 745                 750         


Asp Asp Val Ser Asn Asp Val Arg Met Ala Ala Ala Ser Thr Leu Val 
        755                 760                 765             


Thr Trp Leu Gln Cys Val Lys Gly Ala Asn Ala Lys Ser Tyr Tyr Gln 
    770                 775                 780                 


Ser Ser Val Gln Tyr Leu Tyr Arg Glu Leu Leu Val His Leu Asp Asp 
785                 790                 795                 800 


Pro Glu Arg Ala Ile Gln Asp Ala Ile Leu Glu Val Leu Lys Glu Gly 
                805                 810                 815     


Ser Gly Leu Phe Pro Asp Leu Leu Val Arg Glu Thr Glu Ala Val Ile 
            820                 825                 830         


His Lys His Arg Ser Ala Thr Tyr Cys Glu Gln Leu Leu Gln His Val 
        835                 840                 845             


Gln Ala Val Pro Ala Thr Gln 
    850                 855 


<210>  1905
<211>  3840
<212>  DNA
<213>  Homosapiens

<400>  1905
agagcgtctt ctcgggcctg ggcggcgcag acgaggcctg aggcggcggc gcgaggcagt     60

tccagctatt cttcagatgc tctggatttt gagacggagc acaaattgga ccctgtattt    120

gattctccac ggatgtcccg ccgtagtttg cgcctggcca cgacagcatg caccctgggg    180

gatggtgagg ctgtgggtgc cgacagcggc accagcagcg ctgtctccct gaagaaccga    240

gcggccagaa caacaaaaca gcgcagaagc acaaacaaat cagcttttag tatcaaccac    300

gtgtcaaggc aggtcacgtc ctctggcgtc agccacggcg gcactgtcag cctgcaggat    360

gctgtgactc gacggcctcc tgtattggac gagtcttgga ttcgtgaaca gaccacagtg    420

gaccacttct ggggtcttga tgatgatggt gatcttaaag gtggaaataa agctgccatt    480

cagggaaacg gggatgtggg agccgccgcc gccaccgcgc acaacggctt ctcctgcagc    540

aactgcagca tgctgtccga gcgcaaggac gtgctcacgg cgcaccccgc ggcccccggg    600

cccgtgtcga gagtttattc tagggacagg aatcaaaaat ggaaggcagc ctctggagtg    660

ttctggtggc tggggattgg atggtaccag tttgttactt tgatttcttg gctgaatgtg    720

tttcttctta ccaggtgcct tcgaaacatc tgcaagtttt tagtcttgct catcccactc    780

ttccttttac tagcaggtct ctccttacgg ggccagggca atttcttttc gttcttgccc    840

gtgttgaact gggcaagcat gcatagaaca cagcgggtgg atgaccccca ggacgtgttt    900

aaacccacga cttctcgcct gaagcagcct ctgcagggtg acagtgaggc ttttccgtgg    960

cattggatga gtggcgtgga gcagcaggtg gcctctctgt ctggacagtg ccaccaccat   1020

ggtgagaatc tccgagagct gaccactttg ctacagaagc tgcaggctcg ggtggaccag   1080

atggaaggcg gcgctgccgg gccgtcagct tcggtcagag acgctgtggg acagcccccg   1140

agggagactg actttatggc ctttcaccaa gaacatgaag tgcgtatgtc acacttggaa   1200

gatattctgg gaaaactgag agaaaaatct gaggccatcc agaaggaact agaacagacc   1260

aagcaaaaaa caatcagtgc ggttggtgag cagctcctgc ccacagtcga gcacctccag   1320

ctggagctgg atcagctaaa gtcagagctg tccagctggc gacacgtgaa gaccggctgt   1380

gagacagtgg atgccgtaca agaaagagtg gacgtgcaag tcagagaaat ggtgaaactc   1440

ctgttttccg aagatcagca aggcggttct ctggaacagc tgctgcagag gttctcatca   1500

cagtttgtga gcaaaggcga cttgcagacg atgctgcgag acctgcagct gcagatcctg   1560

cggaacgtca cccaccacgt ttccgtgacc aagcagctcc caacctcaga agccgtggtg   1620

tctgctgtga gcgaggcggg ggcgtctgga ataacagagg cgcaagcacg tgccatcgtg   1680

aacagcgcct tgaagctgta ttcccaagat aagaccggga tggtggactt tgctctggaa   1740

tctggtggtg gcagcatctt gagtactcgc tgttctgaaa cttacgaaac caaaacggcg   1800

ctgatgagtc tgtttgggat cccgctgtgg tacttctcgc agtccccgcg cgtggtcatc   1860

cagcctgaca tttaccccgg taactgctgg gcatttaaag gctcccaggg gtacctggtg   1920

gtgaggctct ccatgatgat ccacccagcc gccttcactc tggagcacat ccctaagacg   1980

ctgtcgccaa caggcaacat cagcagcgcc cccaaggact tcgccgtcta tggattagaa   2040

aatgagtatc aggaagaagg gcagcttctg ggacagttca cgtatgatca ggatggggag   2100

tcgctccaga tgttccaggc cctgaaaaga cccgacgaca cagctttcca aatagtggaa   2160

cttcggattt tttctaactg gggccatcct gagtatacct gtctgtatcg gttcagagtt   2220

catggcgaac ctgtcaagtg aagacactac tcattatttt tgtacatttt tgtatatact   2280

gggacagcgt gaaacactgg aatccttcat ggacgagggc atatacaatg atgggacagt   2340

gccacactcc ttcaataaac gtggctgctg gccagaggac gtgagcgtgt gacgggcgcc   2400

ttggcgccac ctgttgggtg ctcactgcct ctgcaggtgc agaggggtca gcagcaggag   2460

aagcgtgttg aacacgtggc tctcagacac tccttgtttt taacgggaag ctctttgcat   2520

ttgcatttcc tcaacaaagg agcaaagcag aggaagctga gagtctggcg tgttcttgac   2580

gctttggtct tcagccttgc actggctctt ctaaaggact tttggagggc agataatttc   2640

atctgttaaa tccaacacac atttctttca gggaaaaaca atgtcaccaa attttcagag   2700

ttctaaactc ctttccttca agccggaatt ttcctttttt cagcaccagt aggtactaag   2760

tctccagatg gggaaataac taaaatgtgt ttttctgctt tgttcgctct tacttctgag   2820

gaaggtttcc agtcaggact cgctgtacca atatccatgg aggaatatgg gagcgtttcg   2880

ctctccttgt aggctgaagt cagtctgact tgaaggggcc tggtttggat ctaagcaaac   2940

acccagatgg ggttctctgg tctcagcaag gcttttcctg ttgggagtca cagtaaacag   3000

aaacccaaaa atctcatctt gggtgttttc agggcttgtt ttgagttttg ctgaataggg   3060

agcgcaagac gccctgagcc tccctctcac tggtggtgat aagaggagcc gtctggtgtg   3120

tcagggtcac gaacccgtta catttcagga cgatcctttt tccttcagca gcatttctta   3180

ctggctgtgg ctggaatctg ccttttatca cagctgtcac cattctcacg tgattcttgt   3240

gagactcttt ttggttataa ttactattta atatttagac tattttactg agcagacttt   3300

ataaatgaga tatctacaag gcacttaaag tgttacagat gttttacctt aagaattatt   3360

taagttgtgt tgggttaaga cagttttcag tgtaccgtaa atgttgtgtt ttcagaaaaa   3420

gacaaaacga tggtgctgac tggttttctg tatattgcac aacagtcctc aaatacactg   3480

atgtatgaaa ctattcatac atcaagcagc atttttttca ctctccttag aattggaact   3540

atgcagttaa ggcagataaa atgtacagat gtttcatata ttacaggtta catatataaa   3600

tcaaaatttc ctatataaaa ctgatttggg atttggggtg gaaatatttt gaatattaat   3660

ttatttttaa agatgcaaga taggactttg tgcaatgtat ttttgtaaat gcttttcaaa   3720

atatctgtct ttggtagtgc ttctgctgct gccaccaaat tgataagatg ctattaagag   3780

gtttaaataa agagttttaa tttttaaaag ggcatgggat ataaacagtc aaaaaaaaaa   3840


<210>  1906
<211>  702
<212>  PRT
<213>  Homosapiens

<400>  1906

Met Ser Arg Arg Ser Leu Arg Leu Ala Thr Thr Ala Cys Thr Leu Gly 
1               5                   10                  15      


Asp Gly Glu Ala Val Gly Ala Asp Ser Gly Thr Ser Ser Ala Val Ser 
            20                  25                  30          


Leu Lys Asn Arg Ala Ala Arg Thr Thr Lys Gln Arg Arg Ser Thr Asn 
        35                  40                  45              


Lys Ser Ala Phe Ser Ile Asn His Val Ser Arg Gln Val Thr Ser Ser 
    50                  55                  60                  


Gly Val Ser His Gly Gly Thr Val Ser Leu Gln Asp Ala Val Thr Arg 
65                  70                  75                  80  


Arg Pro Pro Val Leu Asp Glu Ser Trp Ile Arg Glu Gln Thr Thr Val 
                85                  90                  95      


Asp His Phe Trp Gly Leu Asp Asp Asp Gly Asp Leu Lys Gly Gly Asn 
            100                 105                 110         


Lys Ala Ala Ile Gln Gly Asn Gly Asp Val Gly Ala Ala Ala Ala Thr 
        115                 120                 125             


Ala His Asn Gly Phe Ser Cys Ser Asn Cys Ser Met Leu Ser Glu Arg 
    130                 135                 140                 


Lys Asp Val Leu Thr Ala His Pro Ala Ala Pro Gly Pro Val Ser Arg 
145                 150                 155                 160 


Val Tyr Ser Arg Asp Arg Asn Gln Lys Trp Lys Ala Ala Ser Gly Val 
                165                 170                 175     


Phe Trp Trp Leu Gly Ile Gly Trp Tyr Gln Phe Val Thr Leu Ile Ser 
            180                 185                 190         


Trp Leu Asn Val Phe Leu Leu Thr Arg Cys Leu Arg Asn Ile Cys Lys 
        195                 200                 205             


Phe Leu Val Leu Leu Ile Pro Leu Phe Leu Leu Leu Ala Gly Leu Ser 
    210                 215                 220                 


Leu Arg Gly Gln Gly Asn Phe Phe Ser Phe Leu Pro Val Leu Asn Trp 
225                 230                 235                 240 


Ala Ser Met His Arg Thr Gln Arg Val Asp Asp Pro Gln Asp Val Phe 
                245                 250                 255     


Lys Pro Thr Thr Ser Arg Leu Lys Gln Pro Leu Gln Gly Asp Ser Glu 
            260                 265                 270         


Ala Phe Pro Trp His Trp Met Ser Gly Val Glu Gln Gln Val Ala Ser 
        275                 280                 285             


Leu Ser Gly Gln Cys His His His Gly Glu Asn Leu Arg Glu Leu Thr 
    290                 295                 300                 


Thr Leu Leu Gln Lys Leu Gln Ala Arg Val Asp Gln Met Glu Gly Gly 
305                 310                 315                 320 


Ala Ala Gly Pro Ser Ala Ser Val Arg Asp Ala Val Gly Gln Pro Pro 
                325                 330                 335     


Arg Glu Thr Asp Phe Met Ala Phe His Gln Glu His Glu Val Arg Met 
            340                 345                 350         


Ser His Leu Glu Asp Ile Leu Gly Lys Leu Arg Glu Lys Ser Glu Ala 
        355                 360                 365             


Ile Gln Lys Glu Leu Glu Gln Thr Lys Gln Lys Thr Ile Ser Ala Val 
    370                 375                 380                 


Gly Glu Gln Leu Leu Pro Thr Val Glu His Leu Gln Leu Glu Leu Asp 
385                 390                 395                 400 


Gln Leu Lys Ser Glu Leu Ser Ser Trp Arg His Val Lys Thr Gly Cys 
                405                 410                 415     


Glu Thr Val Asp Ala Val Gln Glu Arg Val Asp Val Gln Val Arg Glu 
            420                 425                 430         


Met Val Lys Leu Leu Phe Ser Glu Asp Gln Gln Gly Gly Ser Leu Glu 
        435                 440                 445             


Gln Leu Leu Gln Arg Phe Ser Ser Gln Phe Val Ser Lys Gly Asp Leu 
    450                 455                 460                 


Gln Thr Met Leu Arg Asp Leu Gln Leu Gln Ile Leu Arg Asn Val Thr 
465                 470                 475                 480 


His His Val Ser Val Thr Lys Gln Leu Pro Thr Ser Glu Ala Val Val 
                485                 490                 495     


Ser Ala Val Ser Glu Ala Gly Ala Ser Gly Ile Thr Glu Ala Gln Ala 
            500                 505                 510         


Arg Ala Ile Val Asn Ser Ala Leu Lys Leu Tyr Ser Gln Asp Lys Thr 
        515                 520                 525             


Gly Met Val Asp Phe Ala Leu Glu Ser Gly Gly Gly Ser Ile Leu Ser 
    530                 535                 540                 


Thr Arg Cys Ser Glu Thr Tyr Glu Thr Lys Thr Ala Leu Met Ser Leu 
545                 550                 555                 560 


Phe Gly Ile Pro Leu Trp Tyr Phe Ser Gln Ser Pro Arg Val Val Ile 
                565                 570                 575     


Gln Pro Asp Ile Tyr Pro Gly Asn Cys Trp Ala Phe Lys Gly Ser Gln 
            580                 585                 590         


Gly Tyr Leu Val Val Arg Leu Ser Met Met Ile His Pro Ala Ala Phe 
        595                 600                 605             


Thr Leu Glu His Ile Pro Lys Thr Leu Ser Pro Thr Gly Asn Ile Ser 
    610                 615                 620                 


Ser Ala Pro Lys Asp Phe Ala Val Tyr Gly Leu Glu Asn Glu Tyr Gln 
625                 630                 635                 640 


Glu Glu Gly Gln Leu Leu Gly Gln Phe Thr Tyr Asp Gln Asp Gly Glu 
                645                 650                 655     


Ser Leu Gln Met Phe Gln Ala Leu Lys Arg Pro Asp Asp Thr Ala Phe 
            660                 665                 670         


Gln Ile Val Glu Leu Arg Ile Phe Ser Asn Trp Gly His Pro Glu Tyr 
        675                 680                 685             


Thr Cys Leu Tyr Arg Phe Arg Val His Gly Glu Pro Val Lys 
    690                 695                 700         


<210>  1907
<211>  2106
<212>  DNA
<213>  Homosapiens

<400>  1907
agaagggcgt cgggcggccg tcgggacgga agccgggagg cgctgccgac cgcgcctgcg     60

acagcgtcag ccctgcgcgg agcgccggcc cgatggcggc ggcggcggcg atggccgagc    120

aggagagcgc ccggaacggc ggccgcaacc gcggcggcgt ccagcgtgtg gagggcaagc    180

tgcgcgccag cgtcgagaag ggcgactact acgaggcgca ccagatgtac cggaccctgt    240

tcttcaggta catgtcccag agcaagcaca cggaggcccg ggagctcatg tactcgggag    300

ccctgctctt cttcagccat ggccagcaaa acagtgcagc agacttgtcc atgctggtcc    360

tggagtccct ggagaaggcg gaagtggagg tggctgacga gctgctggaa aatctggcta    420

aagtgttcag cctgatggac cccaactctc ctgagcgcgt gacctttgtg tccagagccc    480

tgaagtggtc cagtgggggc tccgggaagc tgggccaccc ccggctgcac cagctgctgg    540

ccctcaccct gtggaaagaa caaaactatt gtgagtcgag gtatcatttt ctgcactcag    600

cggacgggga gggctgtgcc aacatgctgg tggagtattc cacgtcccgc ggcttccgca    660

gcgaggtgga catgttcgtg gcccaggccg tgctacagtt tctctgttta aaaaacaaaa    720

gtagcgcatc ggtggtcttc acgacgtaca cccagaagca cccgtccatc gaggacgggc    780

ctccgtttgt ggagccgctg cttaacttca tctggttcct gctgctggct gtggacggtg    840

ggaagctgac ggtgttcact gtgctgtgtg agcagtacca gccatccctc cggcgggacc    900

ccatgtacaa cgagtacctc gaccgcatag gacagctgtt cttcggcgtc ccgcccaagc    960

agacgtcttc ctacgggggc ctgctcggga accttctgac cagcctcatg ggctcctcag   1020

agcaggagga tggggaggag agccccagcg acggcagccc catcgagctg gactgaactg   1080

gccaggccac gtggagacac cacggtcgac gacggctgga gggacgtttc agaggcgagt   1140

cctgggtggc tcctcgcctt gggggctcct ggccctgagg ctggcggtgg ccgcatgccg   1200

gcgcgtgtct gtttctgtgc ggcggctcag ggtggcgcgg ctgctgctca ctgtgctgct   1260

gggacccaag agtggggcgt cgcccctgct ggccgccgcg tcccccgaga ttgacccaca   1320

ataaagcaca ggccttaccg cggcgtcacc ctctcccact cctttgttct gggtcctttc   1380

gggagggctg atgggcagca caggaggccc gtcctcgggg ggctgcgcac atcacgctcc   1440

ttgccgggcg tccggcacag ctgcggtcac caaagcaggt gctggccctc ggacctgaga   1500

gcccagccag ggcccatgtg gtctgcaaat gggagcggct gtttttgaac acggggtcat   1560

tctgcagtca ggacgaaccg gtccccgtcg cagacggagt gcacgtgccc tgcgccacat   1620

cctcacgctc ggtggaggga cgcgtgcggc gggacggtgc ctacgggtac ttgcagctgt   1680

gtcccatgtg gcatcccaga gctgcgccct gctggtctct gtgagcgcca cgctgctgtg   1740

ctggaaatgc cgctttaaaa agggataccg tgggactctg cccgtctctt tcataacgca   1800

atatttattt gtattgggtg atgattgatt ctttcgacct aacattttgg gttttaacca   1860

aataaccggt ccaggagtga gcagctccgt tctgtcagat gctactccaa atgttaccag   1920

aacgatgaca aaaggggaga cgctctattt tttcacagtt aaatgacagt tgtagattga   1980

tacgcagttg tgcatgggaa ggggaaacgc acagctttat ttactgtaaa gtggaatttc   2040

aggaaggctt gtgtgaaccg ttgcgcataa ataaaccctt tctaccggaa aaaaaaaaaa   2100

aaaaaa                                                              2106


<210>  1908
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  1908

Met Ala Ala Ala Ala Ala Met Ala Glu Gln Glu Ser Ala Arg Asn Gly 
1               5                   10                  15      


Gly Arg Asn Arg Gly Gly Val Gln Arg Val Glu Gly Lys Leu Arg Ala 
            20                  25                  30          


Ser Val Glu Lys Gly Asp Tyr Tyr Glu Ala His Gln Met Tyr Arg Thr 
        35                  40                  45              


Leu Phe Phe Arg Tyr Met Ser Gln Ser Lys His Thr Glu Ala Arg Glu 
    50                  55                  60                  


Leu Met Tyr Ser Gly Ala Leu Leu Phe Phe Ser His Gly Gln Gln Asn 
65                  70                  75                  80  


Ser Ala Ala Asp Leu Ser Met Leu Val Leu Glu Ser Leu Glu Lys Ala 
                85                  90                  95      


Glu Val Glu Val Ala Asp Glu Leu Leu Glu Asn Leu Ala Lys Val Phe 
            100                 105                 110         


Ser Leu Met Asp Pro Asn Ser Pro Glu Arg Val Thr Phe Val Ser Arg 
        115                 120                 125             


Ala Leu Lys Trp Ser Ser Gly Gly Ser Gly Lys Leu Gly His Pro Arg 
    130                 135                 140                 


Leu His Gln Leu Leu Ala Leu Thr Leu Trp Lys Glu Gln Asn Tyr Cys 
145                 150                 155                 160 


Glu Ser Arg Tyr His Phe Leu His Ser Ala Asp Gly Glu Gly Cys Ala 
                165                 170                 175     


Asn Met Leu Val Glu Tyr Ser Thr Ser Arg Gly Phe Arg Ser Glu Val 
            180                 185                 190         


Asp Met Phe Val Ala Gln Ala Val Leu Gln Phe Leu Cys Leu Lys Asn 
        195                 200                 205             


Lys Ser Ser Ala Ser Val Val Phe Thr Thr Tyr Thr Gln Lys His Pro 
    210                 215                 220                 


Ser Ile Glu Asp Gly Pro Pro Phe Val Glu Pro Leu Leu Asn Phe Ile 
225                 230                 235                 240 


Trp Phe Leu Leu Leu Ala Val Asp Gly Gly Lys Leu Thr Val Phe Thr 
                245                 250                 255     


Val Leu Cys Glu Gln Tyr Gln Pro Ser Leu Arg Arg Asp Pro Met Tyr 
            260                 265                 270         


Asn Glu Tyr Leu Asp Arg Ile Gly Gln Leu Phe Phe Gly Val Pro Pro 
        275                 280                 285             


Lys Gln Thr Ser Ser Tyr Gly Gly Leu Leu Gly Asn Leu Leu Thr Ser 
    290                 295                 300                 


Leu Met Gly Ser Ser Glu Gln Glu Asp Gly Glu Glu Ser Pro Ser Asp 
305                 310                 315                 320 


Gly Ser Pro Ile Glu Leu Asp 
                325         


<210>  1909
<211>  2378
<212>  DNA
<213>  Homosapiens

<400>  1909
aattccctcc gccgcggtcg ctgagcgagt gcggcgggaa tgcggaaccg gcgcgcgggc     60

tgaggccgcc cgggatggcg caggggcggc ggcggcgggc ggcctgcgcg gggccctagc    120

gagccgggct gacgctcccg gccccggccc cggcatcggc atcgcgggcg catcgcggcc    180

atggccaagg agcggcgcag ggcggtcctg gagctgctgc agcggccggg gaacgcgcgc    240

tgcgcggact gcggcgcccc ggatcccgac tgggcctcct acactctggg cgtcttcatc    300

tgcctgagct gctcgggaat ccaccggaat atcccccagg tcagcaaggt gaagtccgtc    360

cgcctggacg cctgggagga ggcccaagtg gagttcatgg cctcccacgg gaacgacgcc    420

gcgagagcca ggtttgagtc caaagtaccc tccttctact accggcccac gccctccgac    480

tgccagctcc ttcgagagca gtggatccgg gccaagtacg agcgacagga gttcatctac    540

ccggagaagc aggagcccta ctcggcaggg taccgtgagg gttttctctg gaagcgtggc    600

cgggacaacg ggcagttttt gagccggaag tttgtgctga cagaacgaga gggtgctctg    660

aagtatttca acagaaatga tgccaaggag cccaaggccg tgatgaagat cgagcacctg    720

aatgccacct tccagccggc caagatcggc cacccccacg gcctgcaggt cacctacctg    780

aaggacaaca gcacccgtaa catcttcatc taccatgagg acgggaagga gattgtggac    840

tggttcaatg cactccgagc tgctcgcttc cactacctgc aggtggcatt cccaggggcc    900

agcgacgcag atctggtgcc aaagctctcc aggaactacc tgaaggaagg ctacatggag    960

aagacggggc ccaagcaaac ggaaggcttc cggaagcgct ggttcaccat ggatgaccgc   1020

aggctcatgt acttcaaaga ccccctggac gccttcgccc gaggggaagt cttcattggc   1080

agcaaggaga gtggctacac ggtgctgcat gggttcccgc cgtccaccca gggccaccac   1140

tggccacatg gcatcaccat cgtcacgccc gaccgcaagt ttctgtttgc ctgcgagacg   1200

gagtccgacc agagggagtg ggtggcggcc ttccagaagg cggtggacag gcccatgctg   1260

ccccaggagt acgcagtgga ggcgcacttc aagcataaac cttagcgagt gcggctggag   1320

gaccacggac attggactca ctgtggctgg acggagggga cccgtggatg ggggggctct   1380

ggcgtcctga ggccacctgg ccccacctgc tcctcagggc agcccggcgc ggccaggtag   1440

ggcccgagct tcagcttcca ggatgcttct ctggaacctc aaggcaggca gcccaggccc   1500

tgggcctgat ctctaacccc gtcatgctgc tgctgaccac acccagccaa cctgcccctc   1560

cctgacccgg ggcccccttt cctccagggc ccagtctggc tcccgagctc agacacagcc   1620

cccaggagcc gcccaccacg gctgtgggaa cttccaggcc tcagcgcaga gccctgcttg   1680

gggccagcac ggtgggcagc tgccggccgc tggggactgg gccctgctcg catgccgccc   1740

cgccctcccc ccacctccac gactatttat tgagcgcctg ttgtgtgtca cggggctatg   1800

agggccgtgg ggtgtttggg tggattatcc acacaggtcc cggcccctgc ccgggctgga   1860

gttgccacag cctgtgctcc tggtcctcac ctggaggggc cagcaggctg ccgtcccacc   1920

acacgtggcc tctgcgccca gcacggtgct cgccgacagt ggtgtctgaa cccttgggga   1980

cgagggcctg ggccgcggtg aggccaccag aggcaggagt ggccctgggg gtcccgggca   2040

ctgtcgcgct tgctgcaggc ggcccagccg tgtatttatt tttcacctat ctccttcctg   2100

tcaaggcagg ccgggctcca gggctcccct tgcgtggggc atgtaggtgg gggaggcgtc   2160

tgcaggtcac ctggggggcc cagccctctc ccagccttgc ctggctgagc tgtgttccag   2220

gggagccctg gacaagccct cataggcagg gagggggttt ccgaggccag gcatccgccg   2280

ccccgtgtcg catcctggaa taaaatgtgg ctctggcatg gttaaaaaaa aaaaaaaaaa   2340

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                           2378


<210>  1910
<211>  374
<212>  PRT
<213>  Homosapiens

<400>  1910

Met Ala Lys Glu Arg Arg Arg Ala Val Leu Glu Leu Leu Gln Arg Pro 
1               5                   10                  15      


Gly Asn Ala Arg Cys Ala Asp Cys Gly Ala Pro Asp Pro Asp Trp Ala 
            20                  25                  30          


Ser Tyr Thr Leu Gly Val Phe Ile Cys Leu Ser Cys Ser Gly Ile His 
        35                  40                  45              


Arg Asn Ile Pro Gln Val Ser Lys Val Lys Ser Val Arg Leu Asp Ala 
    50                  55                  60                  


Trp Glu Glu Ala Gln Val Glu Phe Met Ala Ser His Gly Asn Asp Ala 
65                  70                  75                  80  


Ala Arg Ala Arg Phe Glu Ser Lys Val Pro Ser Phe Tyr Tyr Arg Pro 
                85                  90                  95      


Thr Pro Ser Asp Cys Gln Leu Leu Arg Glu Gln Trp Ile Arg Ala Lys 
            100                 105                 110         


Tyr Glu Arg Gln Glu Phe Ile Tyr Pro Glu Lys Gln Glu Pro Tyr Ser 
        115                 120                 125             


Ala Gly Tyr Arg Glu Gly Phe Leu Trp Lys Arg Gly Arg Asp Asn Gly 
    130                 135                 140                 


Gln Phe Leu Ser Arg Lys Phe Val Leu Thr Glu Arg Glu Gly Ala Leu 
145                 150                 155                 160 


Lys Tyr Phe Asn Arg Asn Asp Ala Lys Glu Pro Lys Ala Val Met Lys 
                165                 170                 175     


Ile Glu His Leu Asn Ala Thr Phe Gln Pro Ala Lys Ile Gly His Pro 
            180                 185                 190         


His Gly Leu Gln Val Thr Tyr Leu Lys Asp Asn Ser Thr Arg Asn Ile 
        195                 200                 205             


Phe Ile Tyr His Glu Asp Gly Lys Glu Ile Val Asp Trp Phe Asn Ala 
    210                 215                 220                 


Leu Arg Ala Ala Arg Phe His Tyr Leu Gln Val Ala Phe Pro Gly Ala 
225                 230                 235                 240 


Ser Asp Ala Asp Leu Val Pro Lys Leu Ser Arg Asn Tyr Leu Lys Glu 
                245                 250                 255     


Gly Tyr Met Glu Lys Thr Gly Pro Lys Gln Thr Glu Gly Phe Arg Lys 
            260                 265                 270         


Arg Trp Phe Thr Met Asp Asp Arg Arg Leu Met Tyr Phe Lys Asp Pro 
        275                 280                 285             


Leu Asp Ala Phe Ala Arg Gly Glu Val Phe Ile Gly Ser Lys Glu Ser 
    290                 295                 300                 


Gly Tyr Thr Val Leu His Gly Phe Pro Pro Ser Thr Gln Gly His His 
305                 310                 315                 320 


Trp Pro His Gly Ile Thr Ile Val Thr Pro Asp Arg Lys Phe Leu Phe 
                325                 330                 335     


Ala Cys Glu Thr Glu Ser Asp Gln Arg Glu Trp Val Ala Ala Phe Gln 
            340                 345                 350         


Lys Ala Val Asp Arg Pro Met Leu Pro Gln Glu Tyr Ala Val Glu Ala 
        355                 360                 365             


His Phe Lys His Lys Pro 
    370                 


<210>  1911
<211>  823
<212>  DNA
<213>  Homosapiens

<400>  1911
gggtccttca ggtaggaggt cctgggtgac tttggaagtc cgtagtgtct cattgcagat     60

aatttttagc ttagggcctg gtggctaggt cggttctctc ctttccagtc ggagacctct    120

gccgcaaaca tgctccgcca gatcatcggt caggccaaga agcatccgag cttgatcccc    180

ctctttgtat ttattggaac tggagctact ggagcaacac tgtatctctt gcgtctggca    240

ttgttcaatc cagatgtttg ttgggacaga aataacccag agccctggaa caaactgggt    300

cccaatgatc aatacaagtt ctactcagtg aatgtggatt acagcaagct gaagaaggaa    360

cgtccagatt tctaaatgaa atgtttcact ataacgctgc tttagaatga aggtcttcca    420

gaagccacat ccgcacaatt ttccacttaa ccaggaaata tttctcctct aaatgcatga    480

aatcatgttg gagatctcta ttgtaatctc tattggagat tacaatgatt aaatcaataa    540

ataactgaaa cttgatatgt gtcacttttt tatgctgaaa gtatgctctg aactttagag    600

tataggaaat taactattag aatttaaaga atttcttgaa tttctgtagt ttgaaaatac    660

gactttaagc tgctttagta aaacacttcc attttgtgta tagactgttg gtaacttcac    720

tagagcatac ataacaactg gaactggaaa ttatacaaaa gtaaattggg aaggatactc    780

cagcatctga cactggcaaa atggaaacct ttgagtttct ctt                      823


<210>  1912
<211>  81
<212>  PRT
<213>  Homosapiens

<400>  1912

Met Leu Arg Gln Ile Ile Gly Gln Ala Lys Lys His Pro Ser Leu Ile 
1               5                   10                  15      


Pro Leu Phe Val Phe Ile Gly Thr Gly Ala Thr Gly Ala Thr Leu Tyr 
            20                  25                  30          


Leu Leu Arg Leu Ala Leu Phe Asn Pro Asp Val Cys Trp Asp Arg Asn 
        35                  40                  45              


Asn Pro Glu Pro Trp Asn Lys Leu Gly Pro Asn Asp Gln Tyr Lys Phe 
    50                  55                  60                  


Tyr Ser Val Asn Val Asp Tyr Ser Lys Leu Lys Lys Glu Arg Pro Asp 
65                  70                  75                  80  


Phe 
    


<210>  1913
<211>  3421
<212>  DNA
<213>  Homosapiens

<400>  1913
gtatccgggt cgctgctttc cctattgtct gaggcagccg ccctcgcgct gtgcaatttc     60

tggtctttcg ttgcttctgg tccaggctaa taaagttttt ctttctttaa ttttttttct    120

tctagtttta acgggagaaa ttaactcccc ggggccgccg ggttgactgc gctgcctggg    180

ccggaggtct tctccggcca gggagcgctg tgggaagggg ctcgagcggc cagggccagg    240

cgaggccggg ggggcggggg gttaggggac cgcggggcta ctcttgggag cgcccctgtc    300

cggctggctg cgcgccggtt ttaaatagca tctttcggac ttgtcttcgc ggccccagtc    360

cccgacctcg gcgctgcctg ggctcctgca gcctctccct aagtcttctc caaacgacca    420

cctcacggat tccttatgga tcgcagctcc aagaggaggc aggtgaagcc tttggcagct    480

tctctgctgg aagctcttga ttatgatagt tcagatgaca gtgattttaa agttggagat    540

gcctcagatt ctgaagggag tggtaatgga agtgaagatg cttcaaagga cagtggagaa    600

ggttcctgta gtgattctga agaaaatatt ttagaagaag aactgaatga agatattaaa    660

gtaaaagaag aacaacttaa aaattctgca gaggaagaag tactatcatc agaaaaacaa    720

ttaattaaaa tggaaaagaa ggaagaagaa gaaaatggag aaagacctag aaagaaaaag    780

gagaaagaga aggaaaaaga aaaggaaaag gagaaagaga aggaaagaga gaaggaaaaa    840

gaaaaagcaa cagtatctga gaatgtggct gcttctgctg ctgccaccac accagccaca    900

agtcctcctg ctgttaacac atccccttct gttcccacta cgacaaccgc tacagaggaa    960

caagtcagcg agccaaaaaa atggaacctt cgacgaaacc gaccacttct ggattttgtg   1020

tccatggaag agctgaatga catggatgac tatgacagtg aggatgacaa tgattggcga   1080

cctactgtag taaagagaaa agggagatct gcgtctcaga aagagggaag tgatggagac   1140

aatgaggatg atgaagatga gggaagcggg agtgatgaag acgagaatga tgaaggcaat   1200

gatgaagatc atagtagccc tgccagtgaa gggggttgca agaagaagaa gagtaaagtt   1260

cttagcagaa acagtgctga tgatgaggaa ctgaccaatg atagcctgac cctatctcaa   1320

agcaagagta atgaggactc gctgattctt gagaagagtc aaaactggag ctctcaaaaa   1380

atggaccata ttctgatttg ctgtgtttgt ctgggagata atagtgagga cgctgatgaa   1440

ataattcagt gtgacaattg tggcattaca gtccatgaag gttgttatgg agttgatgga   1500

gagagtgact ctattatgag ttcagcttct gaaaactcca ctgaaccttg gttttgtgat   1560

gcctgtaaat gtggtgtttc tcctagctgt gaactgtgtc ctaatcagga tggaattttc   1620

aaggagacag atgctggaag atgggttcat attgtttgtg ccctgtatgt tcctggagta   1680

gcctttggag atattgacaa attacgacca gtaacactaa cggaaatgaa ctattccaaa   1740

tatggtgcca aggagtgtag cttttgtgaa gaccctcgct ttgctagaac tggggtttgc   1800

attagctgtg atgcagggat gtgcagagcc tatttccatg tgacctgtgc tcaaaaggaa   1860

ggtctgcttt cagaggcagc ggcggaagag gatatagcag atccattctt tgcttattgt   1920

aagcaacatg cagataggtt agacagaaag tggaagagaa aaaactactt ggctctacag   1980

tcctattgta aaatgtcttt gcaagagaga gagaagcaac tatcaccaga agcacaggca   2040

aggatcaatg cccggcttca gcagtatcgt gccaaagcag aactagctcg atctaccaga   2100

ccccaggcct gggttccaag ggaaaaattg cccagaccac tcaccagcag tgcttcagct   2160

attcgtaaac ttatgcggaa agcagaactc atggggatca gtacagatat ctttccagtg   2220

gacaattcag atactagttc tagtgtggat ggaaggagaa aacataagca accagctctc   2280

actgcagatt ttgtgaatta ttattttgag agaaatatgc gcatgattca aattcaggaa   2340

aatatggctg aacaaaagaa tataaaagat aaattagaga atgaacaaga aaagcttcat   2400

gtagaatata ataagctatg tgaatcttta gaagaactac aaaacctgaa tggaaaactt   2460

cgaagtgaag gacaaggaat atgggcttta ctaggcagaa tcacagggca gaagttgaat   2520

ataccggcaa ttttgcgagc acccaaggag agaaaaccaa gtaaaaaaga aggaggcaca   2580

caaaagacat ctactcttcc tgcagtactt tatagttgtg ggatttgtaa gaagaaccat   2640

gatcagcatc ttcttttatt gtgtgatacc tgtaaactac attaccatct tggatgtctg   2700

gatcctcctc ttacaaggat gccaagaaag accaaaaaca gttattggca gtgctcggaa   2760

tgtgaccagg cagggagcag tgacatggaa gcagatatgg ccatggaaac cctaccagat   2820

ggaaccaaac gatcaaggag gcagattaag gaaccagtga aatttgttcc acaggatgtg   2880

ccaccagaac ccaagaagat tccgataaga aacacgagaa ccagaggacg aaaacgaagc   2940

ttcgttcctg aggaagaaaa acatgaggaa agagttccta gagagagaag acaaagacag   3000

tctgtgttgc aaaagaagcc caaggctgaa gatttaagaa ctgaatgtgc aacttgcaag   3060

ggaactggag acaatgaaaa tcttgtcagg tgtgatgaat gcagactctg ctaccatttt   3120

ggctgtttgg atcctccttt gaaaaagtct cctaaacaga caggctacgg atggatatgt   3180

caggaatgtg attcttcatc ttccaaggaa gatgaaaatg aagctgaaag aaaaaatata   3240

tctcaggagc tcaacatgga acagaaaaat ccaaagaaat aaaagatttt ctgtagtgtt   3300

tttgaaaagt ttgcagctta tgtaatagca gataaaattt ctaattgtaa aatgttaaat   3360

tgtaaaatct aatttgcaaa atgttctcaa taaagtcatt caaaatgaaa aaaaaaaaaa   3420

a                                                                   3421


<210>  1914
<211>  948
<212>  PRT
<213>  Homosapiens

<400>  1914

Met Asp Arg Ser Ser Lys Arg Arg Gln Val Lys Pro Leu Ala Ala Ser 
1               5                   10                  15      


Leu Leu Glu Ala Leu Asp Tyr Asp Ser Ser Asp Asp Ser Asp Phe Lys 
            20                  25                  30          


Val Gly Asp Ala Ser Asp Ser Glu Gly Ser Gly Asn Gly Ser Glu Asp 
        35                  40                  45              


Ala Ser Lys Asp Ser Gly Glu Gly Ser Cys Ser Asp Ser Glu Glu Asn 
    50                  55                  60                  


Ile Leu Glu Glu Glu Leu Asn Glu Asp Ile Lys Val Lys Glu Glu Gln 
65                  70                  75                  80  


Leu Lys Asn Ser Ala Glu Glu Glu Val Leu Ser Ser Glu Lys Gln Leu 
                85                  90                  95      


Ile Lys Met Glu Lys Lys Glu Glu Glu Glu Asn Gly Glu Arg Pro Arg 
            100                 105                 110         


Lys Lys Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu 
        115                 120                 125             


Lys Glu Arg Glu Lys Glu Lys Glu Lys Ala Thr Val Ser Glu Asn Val 
    130                 135                 140                 


Ala Ala Ser Ala Ala Ala Thr Thr Pro Ala Thr Ser Pro Pro Ala Val 
145                 150                 155                 160 


Asn Thr Ser Pro Ser Val Pro Thr Thr Thr Thr Ala Thr Glu Glu Gln 
                165                 170                 175     


Val Ser Glu Pro Lys Lys Trp Asn Leu Arg Arg Asn Arg Pro Leu Leu 
            180                 185                 190         


Asp Phe Val Ser Met Glu Glu Leu Asn Asp Met Asp Asp Tyr Asp Ser 
        195                 200                 205             


Glu Asp Asp Asn Asp Trp Arg Pro Thr Val Val Lys Arg Lys Gly Arg 
    210                 215                 220                 


Ser Ala Ser Gln Lys Glu Gly Ser Asp Gly Asp Asn Glu Asp Asp Glu 
225                 230                 235                 240 


Asp Glu Gly Ser Gly Ser Asp Glu Asp Glu Asn Asp Glu Gly Asn Asp 
                245                 250                 255     


Glu Asp His Ser Ser Pro Ala Ser Glu Gly Gly Cys Lys Lys Lys Lys 
            260                 265                 270         


Ser Lys Val Leu Ser Arg Asn Ser Ala Asp Asp Glu Glu Leu Thr Asn 
        275                 280                 285             


Asp Ser Leu Thr Leu Ser Gln Ser Lys Ser Asn Glu Asp Ser Leu Ile 
    290                 295                 300                 


Leu Glu Lys Ser Gln Asn Trp Ser Ser Gln Lys Met Asp His Ile Leu 
305                 310                 315                 320 


Ile Cys Cys Val Cys Leu Gly Asp Asn Ser Glu Asp Ala Asp Glu Ile 
                325                 330                 335     


Ile Gln Cys Asp Asn Cys Gly Ile Thr Val His Glu Gly Cys Tyr Gly 
            340                 345                 350         


Val Asp Gly Glu Ser Asp Ser Ile Met Ser Ser Ala Ser Glu Asn Ser 
        355                 360                 365             


Thr Glu Pro Trp Phe Cys Asp Ala Cys Lys Cys Gly Val Ser Pro Ser 
    370                 375                 380                 


Cys Glu Leu Cys Pro Asn Gln Asp Gly Ile Phe Lys Glu Thr Asp Ala 
385                 390                 395                 400 


Gly Arg Trp Val His Ile Val Cys Ala Leu Tyr Val Pro Gly Val Ala 
                405                 410                 415     


Phe Gly Asp Ile Asp Lys Leu Arg Pro Val Thr Leu Thr Glu Met Asn 
            420                 425                 430         


Tyr Ser Lys Tyr Gly Ala Lys Glu Cys Ser Phe Cys Glu Asp Pro Arg 
        435                 440                 445             


Phe Ala Arg Thr Gly Val Cys Ile Ser Cys Asp Ala Gly Met Cys Arg 
    450                 455                 460                 


Ala Tyr Phe His Val Thr Cys Ala Gln Lys Glu Gly Leu Leu Ser Glu 
465                 470                 475                 480 


Ala Ala Ala Glu Glu Asp Ile Ala Asp Pro Phe Phe Ala Tyr Cys Lys 
                485                 490                 495     


Gln His Ala Asp Arg Leu Asp Arg Lys Trp Lys Arg Lys Asn Tyr Leu 
            500                 505                 510         


Ala Leu Gln Ser Tyr Cys Lys Met Ser Leu Gln Glu Arg Glu Lys Gln 
        515                 520                 525             


Leu Ser Pro Glu Ala Gln Ala Arg Ile Asn Ala Arg Leu Gln Gln Tyr 
    530                 535                 540                 


Arg Ala Lys Ala Glu Leu Ala Arg Ser Thr Arg Pro Gln Ala Trp Val 
545                 550                 555                 560 


Pro Arg Glu Lys Leu Pro Arg Pro Leu Thr Ser Ser Ala Ser Ala Ile 
                565                 570                 575     


Arg Lys Leu Met Arg Lys Ala Glu Leu Met Gly Ile Ser Thr Asp Ile 
            580                 585                 590         


Phe Pro Val Asp Asn Ser Asp Thr Ser Ser Ser Val Asp Gly Arg Arg 
        595                 600                 605             


Lys His Lys Gln Pro Ala Leu Thr Ala Asp Phe Val Asn Tyr Tyr Phe 
    610                 615                 620                 


Glu Arg Asn Met Arg Met Ile Gln Ile Gln Glu Asn Met Ala Glu Gln 
625                 630                 635                 640 


Lys Asn Ile Lys Asp Lys Leu Glu Asn Glu Gln Glu Lys Leu His Val 
                645                 650                 655     


Glu Tyr Asn Lys Leu Cys Glu Ser Leu Glu Glu Leu Gln Asn Leu Asn 
            660                 665                 670         


Gly Lys Leu Arg Ser Glu Gly Gln Gly Ile Trp Ala Leu Leu Gly Arg 
        675                 680                 685             


Ile Thr Gly Gln Lys Leu Asn Ile Pro Ala Ile Leu Arg Ala Pro Lys 
    690                 695                 700                 


Glu Arg Lys Pro Ser Lys Lys Glu Gly Gly Thr Gln Lys Thr Ser Thr 
705                 710                 715                 720 


Leu Pro Ala Val Leu Tyr Ser Cys Gly Ile Cys Lys Lys Asn His Asp 
                725                 730                 735     


Gln His Leu Leu Leu Leu Cys Asp Thr Cys Lys Leu His Tyr His Leu 
            740                 745                 750         


Gly Cys Leu Asp Pro Pro Leu Thr Arg Met Pro Arg Lys Thr Lys Asn 
        755                 760                 765             


Ser Tyr Trp Gln Cys Ser Glu Cys Asp Gln Ala Gly Ser Ser Asp Met 
    770                 775                 780                 


Glu Ala Asp Met Ala Met Glu Thr Leu Pro Asp Gly Thr Lys Arg Ser 
785                 790                 795                 800 


Arg Arg Gln Ile Lys Glu Pro Val Lys Phe Val Pro Gln Asp Val Pro 
                805                 810                 815     


Pro Glu Pro Lys Lys Ile Pro Ile Arg Asn Thr Arg Thr Arg Gly Arg 
            820                 825                 830         


Lys Arg Ser Phe Val Pro Glu Glu Glu Lys His Glu Glu Arg Val Pro 
        835                 840                 845             


Arg Glu Arg Arg Gln Arg Gln Ser Val Leu Gln Lys Lys Pro Lys Ala 
    850                 855                 860                 


Glu Asp Leu Arg Thr Glu Cys Ala Thr Cys Lys Gly Thr Gly Asp Asn 
865                 870                 875                 880 


Glu Asn Leu Val Arg Cys Asp Glu Cys Arg Leu Cys Tyr His Phe Gly 
                885                 890                 895     


Cys Leu Asp Pro Pro Leu Lys Lys Ser Pro Lys Gln Thr Gly Tyr Gly 
            900                 905                 910         


Trp Ile Cys Gln Glu Cys Asp Ser Ser Ser Ser Lys Glu Asp Glu Asn 
        915                 920                 925             


Glu Ala Glu Arg Lys Asn Ile Ser Gln Glu Leu Asn Met Glu Gln Lys 
    930                 935                 940                 


Asn Pro Lys Lys 
945             


<210>  1915
<211>  4259
<212>  DNA
<213>  Homosapiens

<400>  1915
gtatccgggt cgctgctttc cctattgtct gaggcagccg ccctcgcgct gtgcaatttc     60

tggtctttcg ttgcttctgg tccaggctaa taaagttttt ctttctttaa ttttttttct    120

tctagtttta acgggagaaa ttaactcccc ggggccgccg ggttgactgc gctgcctggg    180

ccggaggtct tctccggcca gggagcgctg tgggaagggg ctcgagcggc cagggccagg    240

cgaggccggg ggggcggggg gttaggggac cgcggggcta ctcttgggag cgcccctgtc    300

cggctggctg cgcgccggtt ttaaatagca tctttcggac ttgtcttcgc ggccccagtc    360

cccgacctcg gcgctgcctg ggctcctgca gcctctccct aagtcttctc caaacgacca    420

cctcacggat tccttatgga tcgcagctcc aagaggaggc aggtgaagcc tttggcagct    480

tctctgctgg aagctcttga ttatgatagt tcagatgaca gtgattttaa agttggagat    540

gcctcagatt ctgaagggag tggtaatgga agtgaagatg cttcaaagga cagtggagaa    600

ggttcctgta gtgattctga agaaaatatt ttagaagaag aactgaatga agatattaaa    660

gtaaaagaag aacaacttaa aaattctgca gaggaagaag tactatcatc agaaaaacaa    720

ttaattaaaa tggaaaagaa ggaagaagaa gaaaatggag aaagacctag aaagaaaaag    780

gagaaagaga aggaaaaaga aaaggaaaag gagaaagaga aggaaagaga gaaggaaaaa    840

gaaaaagcaa cagtatctga gaatgtggct gcttctgctg ctgccaccac accagccaca    900

agtcctcctg ctgttaacac atccccttct gttcccacta cgacaaccgc tacagaggaa    960

caagtcagcg agccaaaaaa atggaacctt cgacgaaacc gaccacttct ggattttgtg   1020

tccatggaag agctgaatga catggatgac tatgacagtg aggatgacaa tgattggcga   1080

cctactgtag taaagagaaa agggagatct gcgtctcaga aagagggaag tgatggagac   1140

aatgaggatg atgaagatga gggaagcggg agtgatgaag acgagaatga tgaaggcaat   1200

gatgaagatc atagtagccc tgccagtgaa gggggttgca agaagaagaa gagtaaagtt   1260

cttagcagaa acagtgctga tgatgaggaa ctgaccaatg atagcctgac cctatctcaa   1320

agcaagagta atgaggactc gctgattctt gagaagagtc aaaactggag ctctcaaaaa   1380

atggaccata ttctgatttg ctgtgtttgt ctgggagata atagtgagga cgctgatgaa   1440

ataattcagt gtgacaattg tggcattaca gtccatgaag gttgttatgg agttgatgga   1500

gagagtgact ctattatgag ttcagcttct gaaaactcca ctgaaccttg gttttgtgat   1560

gcctgtaaat gtggtgtttc tcctagctgt gaactgtgtc ctaatcagga tggaattttc   1620

aaggagacag atgctggaag atgggttcat attgtttgtg ccctgtatgt tcctggagta   1680

gcctttggag atattgacaa attacgacca gtaacactaa cggaaatgaa ctattccaaa   1740

tatggtgcca aggagtgtag cttttgtgaa gaccctcgct ttgctagaac tggggtttgc   1800

attagctgtg atgcagggat gtgcagagcc tatttccatg tgacctgtgc tcaaaaggaa   1860

ggtctgcttt cagaggcagc ggcggaagag gatatagcag atccattctt tgcttattgt   1920

aagcaacatg cagataggtt agacagaaag tggaagagaa aaaactactt ggctctacag   1980

tcctattgta aaatgtcttt gcaagagaga gagaagcaac tatcaccaga agcacaggca   2040

aggatcaatg cccggcttca gcagtatcgt gccaaagcag aactagctcg atctaccaga   2100

ccccaggcct gggttccaag ggaaaaattg cccagaccac tcaccagcag tgcttcagct   2160

attcgtaaac ttatgcggaa agcagaactc atggggatca gtacagatat ctttccagtg   2220

gacaattcag atactagttc tagtgtggat ggaaggagaa aacataagca accagctctc   2280

actgcagatt ttgtgaatta ttattttgag agaaatatgc gcatgattca aattcaggaa   2340

aatatggctg aacaaaagaa tataaaagat aaattagaga atgaacaaga aaagcttcat   2400

gtagaatata ataagctatg tgaatcttta gaagaactac aaaacctgaa tggaaaactt   2460

cgaagtgaag gacaaggaat atgggcttta ctaggcagaa tcacagggca gaagttgaat   2520

ataccggcaa ttttgcgagc acccaaggag agaaaaccaa gtaaaaaaga aggaggcaca   2580

caaaagacat ctactcttcc tgcagtactt tatagttgtg ggatttgtaa gaagaaccat   2640

gatcagcatc ttcttttatt gtgtgatacc tgtaaactac attaccatct tggatgtctg   2700

gatcctcctc ttacaaggat gccaagaaag accaaaaaca gttattggca gtgctcggaa   2760

tgtgaccagg cagggagcag tgacatggaa gcagatatgg ccatggaaac cctaccagat   2820

ggaaccaaac gatcaaggag gcagattaag gaaccagtga aatttgttcc acaggatgtg   2880

ccaccagaac ccaagaagat tccgataaga aacacgagaa ccagaggacg aaaacgaagc   2940

ttcgttcctg aggaagaaaa acatgaggaa agagttccta gagagagaag acaaagacag   3000

tctgtgttgc aaaagaagcc caaggctgaa gatttaagaa ctgaatgtgc aacttgcaag   3060

ggaactggag acaatgaaaa tcttgtcaga tacccttcat gagacccaac tctgccacag   3120

ctcatcctcg gaggcaatcc cggaaacctc ttttataagt gtgattttaa aaatgtggat   3180

taaactctcg atagagtaca taaagtaaag gagaacagct atattgtcct ttctataagc   3240

ttgtcactgc aaaaagttgc cttttgcttg tcaggtttgg atagaatata attgattggt   3300

ttgttacttg gactaacaag gcagtagatt tgcctgtgtg gaattttttt tcctattttt   3360

cttctttttg ctttttttgc acttatcaga aatatttgat gtgtgcattg ttgaaaaata   3420

ctggatacat gtcttgtcag aattgtcgta ttaagtaatg tctttccctc ttgcttcttt   3480

ggcaaatgtt gatacacagt gtttggactt actgaagagt tactgaagcc tgtgggactt   3540

aataaataca atatgctact ccctgttgtg attgaacaat acaaataaca aacaagaaag   3600

acaatgcatt ccattagtct gctattctgt ttccttcaac ttcatacata gattcatata   3660

tgaagtactg cattgtaaaa caactataga ctcatattaa atgttatttc tatttataat   3720

attcagcaaa agtgaaagac ttgtgaagca tatgacattc tatttttgac ttattagtcc   3780

tagtgtgaaa gcattaatat tattagcatg aaatttttac ttcagatttt aagctcatga   3840

ataaagatat atctgtgttg atctctagat atttttagta atacccaaat atattcagtc   3900

cttattgttt taatataagc tttctgtgtt cagtataatt ttatttttct caaccttaaa   3960

tatgaactta ggaaataagg agggaagtac aaagattatt gactatacaa cctaccagct   4020

gaaagaaaga tcttcatcaa catctgtatc tttccagagg tatacagaat taaaatttga   4080

tcttcaagct ttaatgatcc agttttaagt caacggcaga agtatgttga atatttcatc   4140

actcaatctt gaactgattt agaagagact ctttgctgaa attgaattgc acttatacat   4200

gtaaattgtc aacatgtaat ttggaatttt ctgattaata aatgtggttt tggacatct    4259


<210>  1916
<211>  888
<212>  PRT
<213>  Homosapiens

<400>  1916

Met Asp Arg Ser Ser Lys Arg Arg Gln Val Lys Pro Leu Ala Ala Ser 
1               5                   10                  15      


Leu Leu Glu Ala Leu Asp Tyr Asp Ser Ser Asp Asp Ser Asp Phe Lys 
            20                  25                  30          


Val Gly Asp Ala Ser Asp Ser Glu Gly Ser Gly Asn Gly Ser Glu Asp 
        35                  40                  45              


Ala Ser Lys Asp Ser Gly Glu Gly Ser Cys Ser Asp Ser Glu Glu Asn 
    50                  55                  60                  


Ile Leu Glu Glu Glu Leu Asn Glu Asp Ile Lys Val Lys Glu Glu Gln 
65                  70                  75                  80  


Leu Lys Asn Ser Ala Glu Glu Glu Val Leu Ser Ser Glu Lys Gln Leu 
                85                  90                  95      


Ile Lys Met Glu Lys Lys Glu Glu Glu Glu Asn Gly Glu Arg Pro Arg 
            100                 105                 110         


Lys Lys Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu 
        115                 120                 125             


Lys Glu Arg Glu Lys Glu Lys Glu Lys Ala Thr Val Ser Glu Asn Val 
    130                 135                 140                 


Ala Ala Ser Ala Ala Ala Thr Thr Pro Ala Thr Ser Pro Pro Ala Val 
145                 150                 155                 160 


Asn Thr Ser Pro Ser Val Pro Thr Thr Thr Thr Ala Thr Glu Glu Gln 
                165                 170                 175     


Val Ser Glu Pro Lys Lys Trp Asn Leu Arg Arg Asn Arg Pro Leu Leu 
            180                 185                 190         


Asp Phe Val Ser Met Glu Glu Leu Asn Asp Met Asp Asp Tyr Asp Ser 
        195                 200                 205             


Glu Asp Asp Asn Asp Trp Arg Pro Thr Val Val Lys Arg Lys Gly Arg 
    210                 215                 220                 


Ser Ala Ser Gln Lys Glu Gly Ser Asp Gly Asp Asn Glu Asp Asp Glu 
225                 230                 235                 240 


Asp Glu Gly Ser Gly Ser Asp Glu Asp Glu Asn Asp Glu Gly Asn Asp 
                245                 250                 255     


Glu Asp His Ser Ser Pro Ala Ser Glu Gly Gly Cys Lys Lys Lys Lys 
            260                 265                 270         


Ser Lys Val Leu Ser Arg Asn Ser Ala Asp Asp Glu Glu Leu Thr Asn 
        275                 280                 285             


Asp Ser Leu Thr Leu Ser Gln Ser Lys Ser Asn Glu Asp Ser Leu Ile 
    290                 295                 300                 


Leu Glu Lys Ser Gln Asn Trp Ser Ser Gln Lys Met Asp His Ile Leu 
305                 310                 315                 320 


Ile Cys Cys Val Cys Leu Gly Asp Asn Ser Glu Asp Ala Asp Glu Ile 
                325                 330                 335     


Ile Gln Cys Asp Asn Cys Gly Ile Thr Val His Glu Gly Cys Tyr Gly 
            340                 345                 350         


Val Asp Gly Glu Ser Asp Ser Ile Met Ser Ser Ala Ser Glu Asn Ser 
        355                 360                 365             


Thr Glu Pro Trp Phe Cys Asp Ala Cys Lys Cys Gly Val Ser Pro Ser 
    370                 375                 380                 


Cys Glu Leu Cys Pro Asn Gln Asp Gly Ile Phe Lys Glu Thr Asp Ala 
385                 390                 395                 400 


Gly Arg Trp Val His Ile Val Cys Ala Leu Tyr Val Pro Gly Val Ala 
                405                 410                 415     


Phe Gly Asp Ile Asp Lys Leu Arg Pro Val Thr Leu Thr Glu Met Asn 
            420                 425                 430         


Tyr Ser Lys Tyr Gly Ala Lys Glu Cys Ser Phe Cys Glu Asp Pro Arg 
        435                 440                 445             


Phe Ala Arg Thr Gly Val Cys Ile Ser Cys Asp Ala Gly Met Cys Arg 
    450                 455                 460                 


Ala Tyr Phe His Val Thr Cys Ala Gln Lys Glu Gly Leu Leu Ser Glu 
465                 470                 475                 480 


Ala Ala Ala Glu Glu Asp Ile Ala Asp Pro Phe Phe Ala Tyr Cys Lys 
                485                 490                 495     


Gln His Ala Asp Arg Leu Asp Arg Lys Trp Lys Arg Lys Asn Tyr Leu 
            500                 505                 510         


Ala Leu Gln Ser Tyr Cys Lys Met Ser Leu Gln Glu Arg Glu Lys Gln 
        515                 520                 525             


Leu Ser Pro Glu Ala Gln Ala Arg Ile Asn Ala Arg Leu Gln Gln Tyr 
    530                 535                 540                 


Arg Ala Lys Ala Glu Leu Ala Arg Ser Thr Arg Pro Gln Ala Trp Val 
545                 550                 555                 560 


Pro Arg Glu Lys Leu Pro Arg Pro Leu Thr Ser Ser Ala Ser Ala Ile 
                565                 570                 575     


Arg Lys Leu Met Arg Lys Ala Glu Leu Met Gly Ile Ser Thr Asp Ile 
            580                 585                 590         


Phe Pro Val Asp Asn Ser Asp Thr Ser Ser Ser Val Asp Gly Arg Arg 
        595                 600                 605             


Lys His Lys Gln Pro Ala Leu Thr Ala Asp Phe Val Asn Tyr Tyr Phe 
    610                 615                 620                 


Glu Arg Asn Met Arg Met Ile Gln Ile Gln Glu Asn Met Ala Glu Gln 
625                 630                 635                 640 


Lys Asn Ile Lys Asp Lys Leu Glu Asn Glu Gln Glu Lys Leu His Val 
                645                 650                 655     


Glu Tyr Asn Lys Leu Cys Glu Ser Leu Glu Glu Leu Gln Asn Leu Asn 
            660                 665                 670         


Gly Lys Leu Arg Ser Glu Gly Gln Gly Ile Trp Ala Leu Leu Gly Arg 
        675                 680                 685             


Ile Thr Gly Gln Lys Leu Asn Ile Pro Ala Ile Leu Arg Ala Pro Lys 
    690                 695                 700                 


Glu Arg Lys Pro Ser Lys Lys Glu Gly Gly Thr Gln Lys Thr Ser Thr 
705                 710                 715                 720 


Leu Pro Ala Val Leu Tyr Ser Cys Gly Ile Cys Lys Lys Asn His Asp 
                725                 730                 735     


Gln His Leu Leu Leu Leu Cys Asp Thr Cys Lys Leu His Tyr His Leu 
            740                 745                 750         


Gly Cys Leu Asp Pro Pro Leu Thr Arg Met Pro Arg Lys Thr Lys Asn 
        755                 760                 765             


Ser Tyr Trp Gln Cys Ser Glu Cys Asp Gln Ala Gly Ser Ser Asp Met 
    770                 775                 780                 


Glu Ala Asp Met Ala Met Glu Thr Leu Pro Asp Gly Thr Lys Arg Ser 
785                 790                 795                 800 


Arg Arg Gln Ile Lys Glu Pro Val Lys Phe Val Pro Gln Asp Val Pro 
                805                 810                 815     


Pro Glu Pro Lys Lys Ile Pro Ile Arg Asn Thr Arg Thr Arg Gly Arg 
            820                 825                 830         


Lys Arg Ser Phe Val Pro Glu Glu Glu Lys His Glu Glu Arg Val Pro 
        835                 840                 845             


Arg Glu Arg Arg Gln Arg Gln Ser Val Leu Gln Lys Lys Pro Lys Ala 
    850                 855                 860                 


Glu Asp Leu Arg Thr Glu Cys Ala Thr Cys Lys Gly Thr Gly Asp Asn 
865                 870                 875                 880 


Glu Asn Leu Val Arg Tyr Pro Ser 
                885             


<210>  1917
<211>  1125
<212>  DNA
<213>  Homosapiens

<400>  1917
ttctgccctc gagcccaccg ggaacgaaag agaagctcta tctcgcctcc aggagcccag     60

ctatgaactc cttctccaca agcgccttcg gtccagttgc cttctccctg gggctgctcc    120

tggtgttgcc tgctgccttc cctgccccag tacccccagg agaagattcc aaagatgtag    180

ccgccccaca cagacagcca ctcacctctt cagaacgaat tgacaaacaa attcggtaca    240

tcctcgacgg catctcagcc ctgagaaagg agacatgtaa caagagtaac atgtgtgaaa    300

gcagcaaaga ggcactggca gaaaacaacc tgaaccttcc aaagatggct gaaaaagatg    360

gatgcttcca atctggattc aatgaggaga cttgcctggt gaaaatcatc actggtcttt    420

tggagtttga ggtataccta gagtacctcc agaacagatt tgagagtagt gaggaacaag    480

ccagagctgt gcagatgagt acaaaagtcc tgatccagtt cctgcagaaa aaggcaaaga    540

atctagatgc aataaccacc cctgacccaa ccacaaatgc cagcctgctg acgaagctgc    600

aggcacagaa ccagtggctg caggacatga caactcatct cattctgcgc agctttaagg    660

agttcctgca gtccagcctg agggctcttc ggcaaatgta gcatgggcac ctcagattgt    720

tgttgttaat gggcattcct tcttctggtc agaaacctgt ccactgggca cagaacttat    780

gttgttctct atggagaact aaaagtatga gcgttaggac actattttaa ttatttttaa    840

tttattaata tttaaatatg tgaagctgag ttaatttatg taagtcatat ttatattttt    900

aagaagtacc acttgaaaca ttttatgtat tagttttgaa ataataatgg aaagtggcta    960

tgcagtttga atatcctttg tttcagagcc agatcatttc ttggaaagtg taggcttacc   1020

tcaaataaat ggctaactta tacatatttt taaagaaata tttatattgt atttatataa   1080

tgtataaatg gtttttatac caataaatgg cattttaaaa aattc                   1125


<210>  1918
<211>  212
<212>  PRT
<213>  Homosapiens

<400>  1918

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  1919
<211>  746
<212>  DNA
<213>  Homosapiens

<400>  1919
ccctgcgcca cacggccgtc gccatggtga agctgagcaa agaggccaag cagagactac     60

agcagctctt caaggggagc cagtttgcca ttcgctgggg ctttatccct cttgtgattt    120

acctgggatt taagaggggt gcagatcccg gaatgcctga accaactgtt ttgagcctac    180

tttggggata aaggattatt tggtcttctg gatttggagg caatcagcgg acagcatgga    240

agatgtgtgc tctggctcgg ataagagatg ggacatcatt cagtcactag ttggatggca    300

caaggctctt cacagacgca tctgtagcag agtggatctt gtactaactt atgatagaat    360

gtatcagaat aaatgttttt aacagtgtta tgcttgagtc ttttttgaat tgaacatgct    420

aggattatca ggtaaaaatt aagccttttg gtactttctc aaaacaggga atttatgtgt    480

atacctaggt gctatttaag cctgtaaatc ccagcacttt gggaggccag ggcgggtgga    540

tcacgatata aaaaaatttt tccaagttat tcctgcccat tgacctaaca tatggattac    600

agtttccctt tgcagtgaat taataactcc ttctaggata ttccgaggta gtaagaatac    660

agatagttct gtttgtgaca aaccaagctg ttacttcctc ctctgcatta aagttctgac    720

tgcaagaaaa aaaaaaaaaa aaaaaa                                         746


<210>  1920
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  1920

Met Val Lys Leu Ser Lys Glu Ala Lys Gln Arg Leu Gln Gln Leu Phe 
1               5                   10                  15      


Lys Gly Ser Gln Phe Ala Ile Arg Trp Gly Phe Ile Pro Leu Val Ile 
            20                  25                  30          


Tyr Leu Gly Phe Lys Arg Gly Ala Asp Pro Gly Met Pro Glu Pro Thr 
        35                  40                  45              


Val Leu Ser Leu Leu Trp Gly 
    50                  55  


<210>  1921
<211>  3768
<212>  DNA
<213>  Homosapiens

<400>  1921
gagaggctgg cggcagtggt ggctctcccg gctgggttgt cagtcagtga gaggaggggg     60

aagatggctc accgggaccc gttctgctag gaagaagggg agcaggtggt gctgctactc    120

gggaggaagc agagcagcct ccgtcgctgt cgctgagagc ctcacgagtc gaggtcctgc    180

aggtggagct ccggcagccg ccctggttga aggtttagaa cagatgtgga aaaatgttta    240

cttcagagaa aggggttgtg gaggaatggt tgtcagagtt taagacatta ccagaaacat    300

ctttaccaaa ttatgccaca aatttgaaag acaagagttc tttagtttca tctctctata    360

aagttatcca ggagccacaa agtgagttgc tagaacctgt ctgtcaccag ctctttgaat    420

tctatcgcag tggagaggag cagttgcttc aatttacgct gcaatttctc ccagaactaa    480

tttggtgcta ccttgcagtc tcagccagca gaaatgtgca tagcagtgga tgcattgaag    540

ctcttcttct aggggtttac aatttggaaa tagttgacaa acagggacat accaaagtat    600

tgagttttac gattccatct ttatccaaac catctgtata ccatgaacct tccagcattg    660

ggtccatggc tctgactgag agtgcactat cccagcatgg tttgtcaaaa gtggtataca    720

gtggacctca tcctcaaagg gagatgctga cagcacagaa tcggtttgaa gtgttgacat    780

tccttttgtt gtgttacaat gctgccttaa cttacatgcc cagtgtttct cttcagtcac    840

tgtgtcaaat ttgttcaaga atctgtgttt gtggatatcc tcgacaacat gtaagaaaat    900

ataaaggtat aagtagcagg ataccagttt cttcaggatt catggtgcaa atgttaacag    960

ggatttattt tgccttttat aatggagaat gggatctagc tcaaaaagca ctggatgata   1020

ttatatacag agcccagcta gaattatatc cagagccatt gctggttgct aatgcaataa   1080

aggcttcatt gcctcatggt cccatgaaat ctaataagga aggtacaagg tgtattcaag   1140

ttgaaatcac accaacttcc tctcgaatat caagaaatgc agtaaccagc atgtcaataa   1200

ggggtcatag gtggaaaaga catggaaata cagaattaac aggtcaagaa gaactgatgg   1260

agatatctga agttgacgag ggattttatt ccagggctgc gtctagtacc agccagtcgg   1320

gtttatcaaa cagtagtcac aattgtagta acaagccaag tataggaaag aaccacagac   1380

ggtcaggagg aagcaaaact ggaggaaaag aaaaagaaac tacaggggaa tcttgcaaag   1440

atcactttgc tcgaaaacaa actcagagag cccaaagtga gaatcttgag cttctctctt   1500

tgaagagact tactttaaca accagccaat ccctacctaa gcctagtagc catggtttgg   1560

ctaagaccgc agcgactgta tttagtaaat cctttgaaca agtcagtggt gtcacagtcc   1620

cacataaccc gtcatctgct gttggttgtg gggctgggac agatgccaat aggttttccg   1680

cttgtagtct ccaagaagaa aagcttattt acgtttcaga aagaactgaa cttccaatga   1740

agcatcaatc aggtcagcag agacctccta gtattagcat tactctgtcc acagattaat   1800

tagtaacata tttttctccc ataacctagt gaacctggaa atacaacttt gcttctttat   1860

gaaagtaccc tgggtctttc atccgtattc ctgacaggag ccctgatgtc ttaaattctg   1920

aaggctcccc tgactttatg aagggaagat tgtctaggtt gcagtaagtt gaaatatggt   1980

tttgttattt cttgattaag attttttccc cttggtttga gtcttttttt tccctcctct   2040

tatttgttat tgttgcccta agattgtcag tgacaataaa ttttgacagg ttgtctaatc   2100

aagttggtta tgtctcatgt gaggttgtaa ggtggttttt cttgttttgg tttggtttgg   2160

ttttttaata gctcctattt tgatggctgt gtgtttggcc ttcagagtca aagggagtct   2220

gcatgtatgg gaactgtttt atagagaatg gggcagaggc acaactccag gaattctcta   2280

gctcctggtc aggaagccaa tctgaaaaca ggcatgtgga aacacaaaaa tgatgtgtat   2340

gaaaagcacc tgatgaaaat atttgtaagc agatcatctt tatgattaga acaatttgct   2400

caaagccctg gaaaatgcct ggtaacccag tgcctagaat attatatgat tccaggggat   2460

ggctagaggc atttctgttg ttatctctga aacattttta tatcaaaaat cagattgctg   2520

gtaggtgtgt tgttttgaag tgttttatct ggatttagca tgtgaagatc cctttcaatt   2580

attaaggtat aataggctgt aaagctgatt taccctactg ctggactttg gaaatcctag   2640

ttagtttgga ctcctataat tcagagcata cgtcattgga agacttcctg gaaatcagtg   2700

taaatcttgc aacatagctc tcaagatacc actgtataat atgtaattgt ttgtctgcaa   2760

atgcattttt catctataaa atgtcatgaa agaaaataaa ggtagtgaaa tatggacaaa   2820

ggacatttat atattaacta aagttgttta tgtttgtgtt cttaaattta aaacacgaag   2880

aaaaagaaat gtctttcttg ttagtgaaca ggcctgtttt aaatatctta gtatgatatc   2940

aaaagaataa tcaatttagt tacctcccaa ctaaaaagta aaaatgaaaa agacgacatg   3000

gcagaagttg aaacaaactt gtatgtatct gtatgtgacc tctagatgga aataaaagtt   3060

tgatgtttgc tagccgtggt ccttttggct atggttgcgg ttcccctgta aagcaaatgt   3120

acttaagtca tcattcagag tgagagagag aaagcacggc tgaggctgag tcagttgacc   3180

gttgaggaag acctaaggag ctgtccagtt cttggctctt tttcactgtg actgcacagc   3240

ggtttccttc ttcatagtcc cttgctgtag tcaccaagag agcatgctag tgttttcctc   3300

ttgttcctgc ttatgcagag ctcagatata tgaaaaattt gtatgctttg aaggctgcca   3360

aagcatttat actctggaca tagttttaac tgcaactgct ttggctacca gtttaaaccg   3420

agttcttcaa aaagcatgaa ctcgttttca ttcattagcc ctgtttacaa tgtggatttt   3480

gacataaatg aatttgattt tcttttagct ccagtaacag aatggaataa gatctattgc   3540

cataaattgt agttaagaac tgtaaggcaa tcgggcagtg aaacttgata ttgtattaac   3600

ttaataggaa ccctgtgtac aatttaaaat atttgtaaaa tatcactgtg aatttacaga   3660

tgtctttttg tcattcttta acaatgaatt tcccctgtgc atagttatta atagtattgg   3720

tattattaaa aactaatttg gcattttaaa aaaaaaaaaa aaaaaaaa                3768


<210>  1922
<211>  521
<212>  PRT
<213>  Homosapiens

<400>  1922

Met Phe Thr Ser Glu Lys Gly Val Val Glu Glu Trp Leu Ser Glu Phe 
1               5                   10                  15      


Lys Thr Leu Pro Glu Thr Ser Leu Pro Asn Tyr Ala Thr Asn Leu Lys 
            20                  25                  30          


Asp Lys Ser Ser Leu Val Ser Ser Leu Tyr Lys Val Ile Gln Glu Pro 
        35                  40                  45              


Gln Ser Glu Leu Leu Glu Pro Val Cys His Gln Leu Phe Glu Phe Tyr 
    50                  55                  60                  


Arg Ser Gly Glu Glu Gln Leu Leu Gln Phe Thr Leu Gln Phe Leu Pro 
65                  70                  75                  80  


Glu Leu Ile Trp Cys Tyr Leu Ala Val Ser Ala Ser Arg Asn Val His 
                85                  90                  95      


Ser Ser Gly Cys Ile Glu Ala Leu Leu Leu Gly Val Tyr Asn Leu Glu 
            100                 105                 110         


Ile Val Asp Lys Gln Gly His Thr Lys Val Leu Ser Phe Thr Ile Pro 
        115                 120                 125             


Ser Leu Ser Lys Pro Ser Val Tyr His Glu Pro Ser Ser Ile Gly Ser 
    130                 135                 140                 


Met Ala Leu Thr Glu Ser Ala Leu Ser Gln His Gly Leu Ser Lys Val 
145                 150                 155                 160 


Val Tyr Ser Gly Pro His Pro Gln Arg Glu Met Leu Thr Ala Gln Asn 
                165                 170                 175     


Arg Phe Glu Val Leu Thr Phe Leu Leu Leu Cys Tyr Asn Ala Ala Leu 
            180                 185                 190         


Thr Tyr Met Pro Ser Val Ser Leu Gln Ser Leu Cys Gln Ile Cys Ser 
        195                 200                 205             


Arg Ile Cys Val Cys Gly Tyr Pro Arg Gln His Val Arg Lys Tyr Lys 
    210                 215                 220                 


Gly Ile Ser Ser Arg Ile Pro Val Ser Ser Gly Phe Met Val Gln Met 
225                 230                 235                 240 


Leu Thr Gly Ile Tyr Phe Ala Phe Tyr Asn Gly Glu Trp Asp Leu Ala 
                245                 250                 255     


Gln Lys Ala Leu Asp Asp Ile Ile Tyr Arg Ala Gln Leu Glu Leu Tyr 
            260                 265                 270         


Pro Glu Pro Leu Leu Val Ala Asn Ala Ile Lys Ala Ser Leu Pro His 
        275                 280                 285             


Gly Pro Met Lys Ser Asn Lys Glu Gly Thr Arg Cys Ile Gln Val Glu 
    290                 295                 300                 


Ile Thr Pro Thr Ser Ser Arg Ile Ser Arg Asn Ala Val Thr Ser Met 
305                 310                 315                 320 


Ser Ile Arg Gly His Arg Trp Lys Arg His Gly Asn Thr Glu Leu Thr 
                325                 330                 335     


Gly Gln Glu Glu Leu Met Glu Ile Ser Glu Val Asp Glu Gly Phe Tyr 
            340                 345                 350         


Ser Arg Ala Ala Ser Ser Thr Ser Gln Ser Gly Leu Ser Asn Ser Ser 
        355                 360                 365             


His Asn Cys Ser Asn Lys Pro Ser Ile Gly Lys Asn His Arg Arg Ser 
    370                 375                 380                 


Gly Gly Ser Lys Thr Gly Gly Lys Glu Lys Glu Thr Thr Gly Glu Ser 
385                 390                 395                 400 


Cys Lys Asp His Phe Ala Arg Lys Gln Thr Gln Arg Ala Gln Ser Glu 
                405                 410                 415     


Asn Leu Glu Leu Leu Ser Leu Lys Arg Leu Thr Leu Thr Thr Ser Gln 
            420                 425                 430         


Ser Leu Pro Lys Pro Ser Ser His Gly Leu Ala Lys Thr Ala Ala Thr 
        435                 440                 445             


Val Phe Ser Lys Ser Phe Glu Gln Val Ser Gly Val Thr Val Pro His 
    450                 455                 460                 


Asn Pro Ser Ser Ala Val Gly Cys Gly Ala Gly Thr Asp Ala Asn Arg 
465                 470                 475                 480 


Phe Ser Ala Cys Ser Leu Gln Glu Glu Lys Leu Ile Tyr Val Ser Glu 
                485                 490                 495     


Arg Thr Glu Leu Pro Met Lys His Gln Ser Gly Gln Gln Arg Pro Pro 
            500                 505                 510         


Ser Ile Ser Ile Thr Leu Ser Thr Asp 
        515                 520     


<210>  1923
<211>  2742
<212>  DNA
<213>  Homosapiens

<400>  1923
gtcactcgta taaaaaccta tgctttgaag gttctcgtgt gtctcggcct gcaggtctcg     60

ctcagagctg tgtccctgaa catccaccct gctggggtgg cttgacgcac ttctgtgcaa    120

atctgttcgc tcgcaaccct acctacctct ctcccgaacc ggagaaaacc ttcggcgggg    180

tccttccggg ttttgtgtcg aatctgcggc ggcgacccgg cgccgcgtca cgcggtggtg    240

aatgtgcggc agtacgcgcg ccgcgtcgtt tacgcggcga tttcatcatg ctccgagccg    300

gcggcgcgcg ccgcttccgt cgccaccctc tctggacagc ccagggccgc aggctcatgc    360

cctctccgcg tccagtgctg cttagaggtg ctcgcgccgc tctgctgctg ctgctgccgc    420

cccggctctt agcccgaccc tcgctcctcc tccgccggtc cctcagcgcg gcctcctgcg    480

ccccgatctc cttgcccgcc gccgcctccc ggagcagcat ggacggcgcg ggggctgagg    540

aggtgctggc acctctgagg ctagcagtgc gccagcaggg agatcttgtg cgaaaactca    600

aagaagataa agcaccccaa gtagacgtag acaaagcagt ggctgagctc aaagcccgca    660

agagggttct ggaagcaaag gagctggcgt tacagcccaa agatgatatt gtagaccgag    720

caaaaatgga agataccctg aagaggaggt ttttctatga tcaagctttt gctatttatg    780

gaggtgttag tggtctgtat gactttgggc cagttggctg tgctttgaag aacaatatta    840

ttcagacctg gaggcagcac tttatccaag aggaacagat cctggagatc gattgcacca    900

tgctcacccc tgagccagtt ttaaagacct ctggccatgt agacaaattt gctgacttca    960

tggtgaaaga cgtaaaaaat ggagaatgtt ttcgtgctga ccatctatta aaagctcatt   1020

tacagaaatt gatgtctgat aagaagtgtt ctgtcgaaaa gaaatcagaa atggaaagtg   1080

ttttggccca gcttgataac tatggacagc aagaacttgc ggatcttttt gtgaactata   1140

atgtaaaatc tcccattact ggaaatgatc tatcccctcc agtgtctttt aacttaatgt   1200

tcaagacttt cattgggcct ggaggaaaca tgcctgggta cttgagacca gaaactgcac   1260

aggggatttt cttgaatttc aaacgacttt tggagttcaa ccaaggaaag ttgccttttg   1320

ctgctgccca gattggaaat tcttttagaa atgagatctc ccctcgatct ggactgatca   1380

gagtcagaga attcacaatg gcagaaattg agcactttgt agatcccagt gagaaagacc   1440

accccaagtt ccagaatgtg gcagaccttc acctttattt gtattcagca aaagcccagg   1500

tcagcggaca gtccgctcgg aaaatgcgcc tgggagatgc tgttgaacag ggtgtgatta   1560

ataacacagt attaggctat ttcattggcc gcatctacct ctacctcacg aaggttggaa   1620

tatctccaga taaactccgc ttccggcagc acatggagaa tgagatggcc cattatgcct   1680

gtgactgttg ggatgcagaa tccaaaacat cctacggttg gattgagatt gttggatgtg   1740

ctgatcgttc ctgttatgac ctctcctgtc atgcacgagc caccaaagtc ccacttgtag   1800

ctgagaaacc tctgaaagaa cccaaaacag tcaatgttgt tcagtttgaa cccagtaagg   1860

gagcaattgg taaggcatat aagaaggatg caaaactggt gatggagtat cttgccattt   1920

gtgatgagtg ctacattaca gaaatggaga tgctgctgaa tgagaaaggg gaattcacaa   1980

ttgaaactga agggaaaaca tttcagttaa caaaagacat gatcaatgtg aagagattcc   2040

agaaaacact atatgtggaa gaagttgttc cgaatgtaat tgaaccttcc ttcggcctgg   2100

gtaggatcat gtatacggta tttgaacata cattccatgt acgagaagga gatgaacaga   2160

gaacattctt cagtttccct gctgtagttg ctccattcaa atgttccgtc ctcccactga   2220

gccaaaacca ggagttcatg ccatttgtca aggaattatc ggaagccctg accaggcatg   2280

gagtatctca caaagtagac gattcctctg ggtcaatcgg aaggcgctat gccaggactg   2340

atgagattgg cgtggctttt ggtgtcacca ttgactttga cacagtgaac aagacccccc   2400

acactgcaac tctgagggac cgtgactcaa tgcggcagat aagagcagag atctctgagc   2460

tgcccagcat agtccaagac ctagccaatg gcaacatcac atgggctgat gtggaggcca   2520

ggtatcctct gtttgaaggg caagagactg gtaaaaaaga gacaatcgag gaatgaggac   2580

aattttgaca acttttgacc acttgcgcta ataaaaaaaa aaaaactact cttatgtcca   2640

ctttacaaaa gaaaacagca ttgtgattac tcccagggac cgtattttat cttcagtggc   2700

tgcctgattt tacccccaca attaaagttg aaggaatcct ga                      2742


<210>  1924
<211>  685
<212>  PRT
<213>  Homosapiens

<400>  1924

Met Asp Gly Ala Gly Ala Glu Glu Val Leu Ala Pro Leu Arg Leu Ala 
1               5                   10                  15      


Val Arg Gln Gln Gly Asp Leu Val Arg Lys Leu Lys Glu Asp Lys Ala 
            20                  25                  30          


Pro Gln Val Asp Val Asp Lys Ala Val Ala Glu Leu Lys Ala Arg Lys 
        35                  40                  45              


Arg Val Leu Glu Ala Lys Glu Leu Ala Leu Gln Pro Lys Asp Asp Ile 
    50                  55                  60                  


Val Asp Arg Ala Lys Met Glu Asp Thr Leu Lys Arg Arg Phe Phe Tyr 
65                  70                  75                  80  


Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr Asp Phe 
                85                  90                  95      


Gly Pro Val Gly Cys Ala Leu Lys Asn Asn Ile Ile Gln Thr Trp Arg 
            100                 105                 110         


Gln His Phe Ile Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys Thr Met 
        115                 120                 125             


Leu Thr Pro Glu Pro Val Leu Lys Thr Ser Gly His Val Asp Lys Phe 
    130                 135                 140                 


Ala Asp Phe Met Val Lys Asp Val Lys Asn Gly Glu Cys Phe Arg Ala 
145                 150                 155                 160 


Asp His Leu Leu Lys Ala His Leu Gln Lys Leu Met Ser Asp Lys Lys 
                165                 170                 175     


Cys Ser Val Glu Lys Lys Ser Glu Met Glu Ser Val Leu Ala Gln Leu 
            180                 185                 190         


Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp Leu Phe Val Asn Tyr Asn 
        195                 200                 205             


Val Lys Ser Pro Ile Thr Gly Asn Asp Leu Ser Pro Pro Val Ser Phe 
    210                 215                 220                 


Asn Leu Met Phe Lys Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly 
225                 230                 235                 240 


Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg 
                245                 250                 255     


Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile 
            260                 265                 270         


Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg 
        275                 280                 285             


Val Arg Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp Pro Ser 
    290                 295                 300                 


Glu Lys Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr 
305                 310                 315                 320 


Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met 
                325                 330                 335     


Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Thr Val Leu 
            340                 345                 350         


Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile 
        355                 360                 365             


Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu Met Ala 
    370                 375                 380                 


His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly 
385                 390                 395                 400 


Trp Ile Glu Ile Val Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser 
                405                 410                 415     


Cys His Ala Arg Ala Thr Lys Val Pro Leu Val Ala Glu Lys Pro Leu 
            420                 425                 430         


Lys Glu Pro Lys Thr Val Asn Val Val Gln Phe Glu Pro Ser Lys Gly 
        435                 440                 445             


Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val Met Glu Tyr 
    450                 455                 460                 


Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu 
465                 470                 475                 480 


Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln 
                485                 490                 495     


Leu Thr Lys Asp Met Ile Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr 
            500                 505                 510         


Val Glu Glu Val Val Pro Asn Val Ile Glu Pro Ser Phe Gly Leu Gly 
        515                 520                 525             


Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe His Val Arg Glu Gly 
    530                 535                 540                 


Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe 
545                 550                 555                 560 


Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe 
                565                 570                 575     


Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His Gly Val Ser His Lys 
            580                 585                 590         


Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp 
        595                 600                 605             


Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp Phe Asp Thr Val Asn 
    610                 615                 620                 


Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln 
625                 630                 635                 640 


Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln Asp Leu Ala 
                645                 650                 655     


Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe 
            660                 665                 670         


Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu 
        675                 680                 685 


<210>  1925
<211>  2107
<212>  DNA
<213>  Homosapiens

<400>  1925
atggacgcgg cactgctcca cagcctgctg gaggccaact gcagcctggc gctggctgaa     60

gagctgctct tggacggctg ggggccaccc ctggaccccg agggtcccta ctcctactgc    120

aacacgacct tggaccagat cggaacgtgc tggccccgca gcgctgccgg agccctcgtg    180

gagaggccgt gccccgagta cttcaacggc gtcaagtaca acacgacccg gaatgcctat    240

cgagaatgct tggagaatgg gacgtgggcc tcaaagatca actactcaca gtgtgagccc    300

attttggatg acaagcagag gaagtatgac ctgcactacc gcatcgccct tgtcgtcaac    360

tacctgggcc actgcgtatc tgtggcagcc ctggtggccg ccttcctgct tttcctggcc    420

ctgcggagca ttcgctgtct gcggaatgtg attcactgga acctcatcac cacctttatc    480

ctgcgaaatg tcatgtggtt cctgctgcag ctcgttgacc atgaagtgca cgagagcaat    540

gaggtctggt gccgctgcat caccaccatc ttcaactact tcgtggtgac caacttcttc    600

tggatgtttg tggaaggctg ctacctgcac acggccattg tcatgaccta ctccactgag    660

cgcctgcgca agtgcctctt cctcttcatc ggatggtgca tccccttccc catcatcgtc    720

gcctgggcca tcggcaagct ctactatgag aatgaacagt gctggtttgg caaggagcct    780

ggcgacctgg tggactacat ctaccaaggc cccatcattc tcgtgctcct gatcaatttc    840

gtatttctgt tcaacatcgt caggatccta atgacaaagt tacgcgcgtc caccacatcc    900

gagacaatcc agtacaggaa ggcagtgaag gccaccctgg tgctcctgcc cctcctgggc    960

atcacctaca tgctcttctt cgtcaatccc ggggaggacg acctgtcaca gatcatgttc   1020

atctatttca actccttcct gcagtcgttc cagggtttct tcgtgtctgt cttctactgc   1080

ttcttcaatg gagaggtgcg ctcagccgtg aggaagaggt ggcaccgctg gcaggaccat   1140

cactcccttc gagtccccat ggcccgggcc atgtccatcc ctacatcacc cacacggatc   1200

agcttccaca gcatcaagca gacggccgct gtgtgacccc tcggtcgccc acctgcacag   1260

ctcccctgtc ctcctccacc ttcttcctct gggttctctg tgctgggcag gctctcgtgg   1320

ggcaggagat gggaggggag agaccagctc tccagcctgg caggaaagag ggggtgcggc   1380

agccaagggg gactgcaagg gacagggatg agtgggggcc accaggctca gcgcaagagg   1440

aagcagaggg aattcacagg accccctgag aagagccagt cagatgtctg caggcatttg   1500

cccatcccag cctctctggc cagggcctta ctgggcccag agcagagaag gacctgtcca   1560

acacacacag ctatttatag tagcagacac agggctcccc tgccctactc atggagccag   1620

cagccaggca atggtgtggc cctgcactgg cccttggact ccacactcag tggtgccctg   1680

cagttgggtg ggttacgcca gcaaaggatc agtttggctg ccttatccca gggctgtcac   1740

ctagagaggc tcacttgtac cccaccctgt tcctgtgtcc cctccccagc catcctcccg   1800

ccttgggggc tccatgaagg atgcaggctt ccaggcctgg cttcctctct tgggagaccc   1860

cttctctgcc tagtccacag attaggcaat caaggaagac gccatcaggg aagccacatc   1920

cttagtcaac cagttgcatc gtgcggggca aaatgaggag cagaggcatg gaggagggag   1980

gcgtgggatg ggaatagcag aaccaccatg tcttcagtga ttgaaactca taccccattg   2040

ccctttgccc tccagtctcc ccttcagaaa catctctgct ctctgtgaaa taaaccatgc   2100

ctcttgg                                                             2107


<210>  1926
<211>  411
<212>  PRT
<213>  Homosapiens

<400>  1926

Met Asp Ala Ala Leu Leu His Ser Leu Leu Glu Ala Asn Cys Ser Leu 
1               5                   10                  15      


Ala Leu Ala Glu Glu Leu Leu Leu Asp Gly Trp Gly Pro Pro Leu Asp 
            20                  25                  30          


Pro Glu Gly Pro Tyr Ser Tyr Cys Asn Thr Thr Leu Asp Gln Ile Gly 
        35                  40                  45              


Thr Cys Trp Pro Arg Ser Ala Ala Gly Ala Leu Val Glu Arg Pro Cys 
    50                  55                  60                  


Pro Glu Tyr Phe Asn Gly Val Lys Tyr Asn Thr Thr Arg Asn Ala Tyr 
65                  70                  75                  80  


Arg Glu Cys Leu Glu Asn Gly Thr Trp Ala Ser Lys Ile Asn Tyr Ser 
                85                  90                  95      


Gln Cys Glu Pro Ile Leu Asp Asp Lys Gln Arg Lys Tyr Asp Leu His 
            100                 105                 110         


Tyr Arg Ile Ala Leu Val Val Asn Tyr Leu Gly His Cys Val Ser Val 
        115                 120                 125             


Ala Ala Leu Val Ala Ala Phe Leu Leu Phe Leu Ala Leu Arg Ser Ile 
    130                 135                 140                 


Arg Cys Leu Arg Asn Val Ile His Trp Asn Leu Ile Thr Thr Phe Ile 
145                 150                 155                 160 


Leu Arg Asn Val Met Trp Phe Leu Leu Gln Leu Val Asp His Glu Val 
                165                 170                 175     


His Glu Ser Asn Glu Val Trp Cys Arg Cys Ile Thr Thr Ile Phe Asn 
            180                 185                 190         


Tyr Phe Val Val Thr Asn Phe Phe Trp Met Phe Val Glu Gly Cys Tyr 
        195                 200                 205             


Leu His Thr Ala Ile Val Met Thr Tyr Ser Thr Glu Arg Leu Arg Lys 
    210                 215                 220                 


Cys Leu Phe Leu Phe Ile Gly Trp Cys Ile Pro Phe Pro Ile Ile Val 
225                 230                 235                 240 


Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Glu Asn Glu Gln Cys Trp Phe 
                245                 250                 255     


Gly Lys Glu Pro Gly Asp Leu Val Asp Tyr Ile Tyr Gln Gly Pro Ile 
            260                 265                 270         


Ile Leu Val Leu Leu Ile Asn Phe Val Phe Leu Phe Asn Ile Val Arg 
        275                 280                 285             


Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile Gln 
    290                 295                 300                 


Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Asp Leu Ser 
                325                 330                 335     


Gln Ile Met Phe Ile Tyr Phe Asn Ser Phe Leu Gln Ser Phe Gln Gly 
            340                 345                 350         


Phe Phe Val Ser Val Phe Tyr Cys Phe Phe Asn Gly Glu Val Arg Ser 
        355                 360                 365             


Ala Val Arg Lys Arg Trp His Arg Trp Gln Asp His His Ser Leu Arg 
    370                 375                 380                 


Val Pro Met Ala Arg Ala Met Ser Ile Pro Thr Ser Pro Thr Arg Ile 
385                 390                 395                 400 


Ser Phe His Ser Ile Lys Gln Thr Ala Ala Val 
                405                 410     


<210>  1927
<211>  918
<212>  DNA
<213>  Homosapiens

<400>  1927
atgcctggcc acaatacctc caggaattcc tcttgcgatc ctatagtgac accccactta     60

atcagcctct acttcatagt gcttattggc gggctggtgg gtgtcatttc cattcttttc    120

ctcctggtga aaatgaacac ccggtcagtg accaccatgg cggtcattaa cttggtggtg    180

gtccacagcg tttttctgct gacagtgcca tttcgcttga cctacctcat caagaagact    240

tggatgtttg ggctgccctt ctgcaaattt gtgagtgcca tgctgcacat ccacatgtac    300

ctcacgttcc tattctatgt ggtgatcctg gtcaccagat acctcatctt cttcaagtgc    360

aaagacaaag tggaattcta cagaaaactg catgctgtgg ctgccagtgc tggcatgtgg    420

acgctggtga ttgtcattgt ggtacccctg gttgtctccc ggtatggaat ccatgaggaa    480

tacaatgagg agcactgttt taaatttcac aaagagcttg cttacacata tgtgaaaatc    540

atcaactata tgatagtcat ttttgtcata gccgttgctg tgattctgtt ggtcttccag    600

gtcttcatca ttatgttgat ggtgcagaag ctacgccact ctttactatc ccaccaggag    660

ttctgggctc agctgaaaaa cctatttttt ataggggtca tccttgtttg tttccttccc    720

taccagttct ttaggatcta ttacttgaat gttgtgacgc attccaatgc ctgtaacagc    780

aaggttgcat tttataacga aatcttcttg agtgtaacag caattagctg ctatgatttg    840

cttctctttg tctttggggg aagccattgg tttaagcaaa agataattgg cttatggaat    900

tgtgttttgt gccgttag                                                  918


<210>  1928
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  1928

Met Pro Gly His Asn Thr Ser Arg Asn Ser Ser Cys Asp Pro Ile Val 
1               5                   10                  15      


Thr Pro His Leu Ile Ser Leu Tyr Phe Ile Val Leu Ile Gly Gly Leu 
            20                  25                  30          


Val Gly Val Ile Ser Ile Leu Phe Leu Leu Val Lys Met Asn Thr Arg 
        35                  40                  45              


Ser Val Thr Thr Met Ala Val Ile Asn Leu Val Val Val His Ser Val 
    50                  55                  60                  


Phe Leu Leu Thr Val Pro Phe Arg Leu Thr Tyr Leu Ile Lys Lys Thr 
65                  70                  75                  80  


Trp Met Phe Gly Leu Pro Phe Cys Lys Phe Val Ser Ala Met Leu His 
                85                  90                  95      


Ile His Met Tyr Leu Thr Phe Leu Phe Tyr Val Val Ile Leu Val Thr 
            100                 105                 110         


Arg Tyr Leu Ile Phe Phe Lys Cys Lys Asp Lys Val Glu Phe Tyr Arg 
        115                 120                 125             


Lys Leu His Ala Val Ala Ala Ser Ala Gly Met Trp Thr Leu Val Ile 
    130                 135                 140                 


Val Ile Val Val Pro Leu Val Val Ser Arg Tyr Gly Ile His Glu Glu 
145                 150                 155                 160 


Tyr Asn Glu Glu His Cys Phe Lys Phe His Lys Glu Leu Ala Tyr Thr 
                165                 170                 175     


Tyr Val Lys Ile Ile Asn Tyr Met Ile Val Ile Phe Val Ile Ala Val 
            180                 185                 190         


Ala Val Ile Leu Leu Val Phe Gln Val Phe Ile Ile Met Leu Met Val 
        195                 200                 205             


Gln Lys Leu Arg His Ser Leu Leu Ser His Gln Glu Phe Trp Ala Gln 
    210                 215                 220                 


Leu Lys Asn Leu Phe Phe Ile Gly Val Ile Leu Val Cys Phe Leu Pro 
225                 230                 235                 240 


Tyr Gln Phe Phe Arg Ile Tyr Tyr Leu Asn Val Val Thr His Ser Asn 
                245                 250                 255     


Ala Cys Asn Ser Lys Val Ala Phe Tyr Asn Glu Ile Phe Leu Ser Val 
            260                 265                 270         


Thr Ala Ile Ser Cys Tyr Asp Leu Leu Leu Phe Val Phe Gly Gly Ser 
        275                 280                 285             


His Trp Phe Lys Gln Lys Ile Ile Gly Leu Trp Asn Cys Val Leu Cys 
    290                 295                 300                 


Arg 
305 


<210>  1929
<211>  2350
<212>  DNA
<213>  Homosapiens

<400>  1929
ggagtttggg gatgaggcag ctgaagaaca gagtcttgtg atggtggaac caggacttcg     60

ttgttccttc attgtgtggg cagaagaggt ggaggatttt aggcgccacc tggtcttgtc    120

cccactgccc agacaggcag ggaatccctc ttcttccttt tgctgaatca gctggagaag    180

aaagcccagc aggaggcctg ctagcctcag cctcgggccc taccagggtc ctaggtactg    240

gaatggaact tcgccgaggt caccgctcaa acggccacaa cgagggagcc gatttagatc    300

ctctgggcct gttccttcct tttctttaaa cgtcccagtc tagcttagag gaggacctgt    360

tttgttagat aaatggcaag caaaaaacga gaagtccagt tacagacagt catcaataat    420

caaagcctgt gggatgagat gttgcagaac aaaggcttaa cagtgattga tgtttaccaa    480

gcctggtgtg gaccttgcag agcaatgcaa cctttattca gaaaattgaa aaatgaactg    540

aacgaagacg aaattctgca ttttgctgtc gcagaagctg acaacattgt gactttgcag    600

ccatttagag ataaatgtga acctgttttt ctctttagtg ttaatggcaa aattatcgaa    660

aagattcagg gtgcaaatgc accgcttgtt aataaaaaag ttattaattt gatcgatgag    720

gagagaaaaa ttgcagcagg tgaaatggct cgacctcagt atcctgaaat tccattagta    780

gactcagatt cagaagttag tgaagaatca ccatgtgaaa gtgttcagga attatacagt    840

attgctatta tcaaaccgga tgctgtgatt agtaaaaaag ttctagaaat taaaagaaaa    900

attaccaaag ctggatttat tatagaagca gagcataaga cagtgctcac tgaagaacaa    960

gttgtcaact tctatagtcg aatagcagac cagcgtgact tcgaagagtt tgtctctttt   1020

atgacaagtg gcttaagcta tattctagtt gtatctcaag gaagtaaaca caatcctccc   1080

tctgaagaaa ccgaaccaca gactgacacc gaacctaacg aacgatctga ggatcaacct   1140

gaggtcgaag cccaggttac acctggaatg atgaagaaca aacaagacag tttacaagaa   1200

tatctggaaa gacaacattt agctcagctc tgtgacattg aagaggatgc agctaatgtt   1260

gctaagttca tggatgcttt cttccccgat tttaaaaaaa tgaaaagcat gaaattagaa   1320

aagacattgg cattacttcg accaaatctc tttcatgaaa ggaaagatga tgttttgcgt   1380

attattaaag atgaagactt caaaatactg gagcaaagac aagtagtatt atcggaaaaa   1440

gaagcacaag cactgtgcaa ggaatatgaa aatgaagact attttaataa acttatagaa   1500

aacatgacca gtggtccatc tctagccctt gttttattga gagacaatgg cttgcaatac   1560

tggaaacaat tactgggacc aagaactgtt gaagaagcca ttgaatattt tccagagagt   1620

ttatgtgcac agtttgcgat ggacagtttg ccggtcaacc agttgtatgg cagcgattca   1680

ttagaaaccg ctgaaaggga aatacagcat ttctttcctc ttcaaagcac tttaggcttg   1740

attaaacctc atgcaacaag tgaacaaaga gagcagatcc tgaagatagt taaggaggct   1800

ggatttgatc tgacacaggt gaagaaaatg ttcctaactc ctgagcaaac tgagaaaatt   1860

tatccaaaag taacaggaaa agacttttat aaagatttat tggaaatgtt atctgtgggt   1920

ccatctatgg tcatgattct gaccaagtgg aatgctgttg cagaatggag acgattgatg   1980

ggcccaacag acccagaaga agcaaaatta ctttcccctg actccatccg agcccagttt   2040

ggaataagta aattgaaaaa cattgtccat ggagcatcta acgcctatga agcaaaagag   2100

gttgttaata gactctttga ggatcctgag gaaaactaaa gtatatactg tgaaaacttt   2160

gagaagataa tacatatgtt cacgtcaata tacaaccatt tggcacagct tcctgggagg   2220

aataataaga aaaacatgct ttggaggaaa actcaagata caaaaatgaa tggctatgca   2280

taataacaat aaaaatgtat tccccaacca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2340

aaaaaaaaaa                                                          2350


<210>  1930
<211>  588
<212>  PRT
<213>  Homosapiens

<400>  1930

Met Ala Ser Lys Lys Arg Glu Val Gln Leu Gln Thr Val Ile Asn Asn 
1               5                   10                  15      


Gln Ser Leu Trp Asp Glu Met Leu Gln Asn Lys Gly Leu Thr Val Ile 
            20                  25                  30          


Asp Val Tyr Gln Ala Trp Cys Gly Pro Cys Arg Ala Met Gln Pro Leu 
        35                  40                  45              


Phe Arg Lys Leu Lys Asn Glu Leu Asn Glu Asp Glu Ile Leu His Phe 
    50                  55                  60                  


Ala Val Ala Glu Ala Asp Asn Ile Val Thr Leu Gln Pro Phe Arg Asp 
65                  70                  75                  80  


Lys Cys Glu Pro Val Phe Leu Phe Ser Val Asn Gly Lys Ile Ile Glu 
                85                  90                  95      


Lys Ile Gln Gly Ala Asn Ala Pro Leu Val Asn Lys Lys Val Ile Asn 
            100                 105                 110         


Leu Ile Asp Glu Glu Arg Lys Ile Ala Ala Gly Glu Met Ala Arg Pro 
        115                 120                 125             


Gln Tyr Pro Glu Ile Pro Leu Val Asp Ser Asp Ser Glu Val Ser Glu 
    130                 135                 140                 


Glu Ser Pro Cys Glu Ser Val Gln Glu Leu Tyr Ser Ile Ala Ile Ile 
145                 150                 155                 160 


Lys Pro Asp Ala Val Ile Ser Lys Lys Val Leu Glu Ile Lys Arg Lys 
                165                 170                 175     


Ile Thr Lys Ala Gly Phe Ile Ile Glu Ala Glu His Lys Thr Val Leu 
            180                 185                 190         


Thr Glu Glu Gln Val Val Asn Phe Tyr Ser Arg Ile Ala Asp Gln Arg 
        195                 200                 205             


Asp Phe Glu Glu Phe Val Ser Phe Met Thr Ser Gly Leu Ser Tyr Ile 
    210                 215                 220                 


Leu Val Val Ser Gln Gly Ser Lys His Asn Pro Pro Ser Glu Glu Thr 
225                 230                 235                 240 


Glu Pro Gln Thr Asp Thr Glu Pro Asn Glu Arg Ser Glu Asp Gln Pro 
                245                 250                 255     


Glu Val Glu Ala Gln Val Thr Pro Gly Met Met Lys Asn Lys Gln Asp 
            260                 265                 270         


Ser Leu Gln Glu Tyr Leu Glu Arg Gln His Leu Ala Gln Leu Cys Asp 
        275                 280                 285             


Ile Glu Glu Asp Ala Ala Asn Val Ala Lys Phe Met Asp Ala Phe Phe 
    290                 295                 300                 


Pro Asp Phe Lys Lys Met Lys Ser Met Lys Leu Glu Lys Thr Leu Ala 
305                 310                 315                 320 


Leu Leu Arg Pro Asn Leu Phe His Glu Arg Lys Asp Asp Val Leu Arg 
                325                 330                 335     


Ile Ile Lys Asp Glu Asp Phe Lys Ile Leu Glu Gln Arg Gln Val Val 
            340                 345                 350         


Leu Ser Glu Lys Glu Ala Gln Ala Leu Cys Lys Glu Tyr Glu Asn Glu 
        355                 360                 365             


Asp Tyr Phe Asn Lys Leu Ile Glu Asn Met Thr Ser Gly Pro Ser Leu 
    370                 375                 380                 


Ala Leu Val Leu Leu Arg Asp Asn Gly Leu Gln Tyr Trp Lys Gln Leu 
385                 390                 395                 400 


Leu Gly Pro Arg Thr Val Glu Glu Ala Ile Glu Tyr Phe Pro Glu Ser 
                405                 410                 415     


Leu Cys Ala Gln Phe Ala Met Asp Ser Leu Pro Val Asn Gln Leu Tyr 
            420                 425                 430         


Gly Ser Asp Ser Leu Glu Thr Ala Glu Arg Glu Ile Gln His Phe Phe 
        435                 440                 445             


Pro Leu Gln Ser Thr Leu Gly Leu Ile Lys Pro His Ala Thr Ser Glu 
    450                 455                 460                 


Gln Arg Glu Gln Ile Leu Lys Ile Val Lys Glu Ala Gly Phe Asp Leu 
465                 470                 475                 480 


Thr Gln Val Lys Lys Met Phe Leu Thr Pro Glu Gln Thr Glu Lys Ile 
                485                 490                 495     


Tyr Pro Lys Val Thr Gly Lys Asp Phe Tyr Lys Asp Leu Leu Glu Met 
            500                 505                 510         


Leu Ser Val Gly Pro Ser Met Val Met Ile Leu Thr Lys Trp Asn Ala 
        515                 520                 525             


Val Ala Glu Trp Arg Arg Leu Met Gly Pro Thr Asp Pro Glu Glu Ala 
    530                 535                 540                 


Lys Leu Leu Ser Pro Asp Ser Ile Arg Ala Gln Phe Gly Ile Ser Lys 
545                 550                 555                 560 


Leu Lys Asn Ile Val His Gly Ala Ser Asn Ala Tyr Glu Ala Lys Glu 
                565                 570                 575     


Val Val Asn Arg Leu Phe Glu Asp Pro Glu Glu Asn 
            580                 585             


<210>  1931
<211>  2820
<212>  DNA
<213>  Homosapiens

<400>  1931
ggcgggttcg cgccccgaag gctgagagct ggcgctgctc gtgccctgtg tgccagacgg     60

cggagctccg cggccggacc ccgcggcccc gctttgctgc cgactggagt ttgggggaag    120

aaactctcct gcgccccaga agatttcttc ctcggcgaag ggacagcgaa agatgagggt    180

ggcaggaaga gaaggcgctt tctgtctgcc ggggtcgcag cgcgagaggg cagtgccatg    240

ttcctctcca tcctagtggc gctgtgcctg tggctgcacc tggcgctggg cgtgcgcggc    300

gcgccctgcg aggcggtgcg catccctatg tgccggcaca tgccctggaa catcacgcgg    360

atgcccaacc acctgcacca cagcacgcag gagaacgcca tcctggccat cgagcagtac    420

gaggagctgg tggacgtgaa ctgcagcgcc gtgctgcgct tcttcttctg tgccatgtac    480

gcgcccattt gcaccctgga gttcctgcac gaccctatca agccgtgcaa gtcggtgtgc    540

caacgcgcgc gcgacgactg cgagcccctc atgaagatgt acaaccacag ctggcccgaa    600

agcctggcct gcgacgagct gcctgtctat gaccgtggcg tgtgcatttc gcctgaagcc    660

atcgtcacgg acctcccgga ggatgttaag tggatagaca tcacaccaga catgatggta    720

caggaaaggc ctcttgatgt tgactgtaaa cgcctaagcc ccgatcggtg caagtgtaaa    780

aaggtgaagc caactttggc aacgtatctc agcaaaaact acagctatgt tattcatgcc    840

aaaataaaag ctgtgcagag gagtggctgc aatgaggtca caacggtggt ggatgtaaaa    900

gagatcttca agtcctcatc acccatccct cgaactcaag tcccgctcat tacaaattct    960

tcttgccagt gtccacacat cctgccccat caagatgttc tcatcatgtg ttacgagtgg   1020

cgttcaagga tgatgcttct tgaaaattgc ttagttgaaa aatggagaga tcagcttagt   1080

aaaagatcca tacagtggga agagaggctg caggaacagc ggagaacagt tcaggacaag   1140

aagaaaacag ccgggcgcac cagtcgtagt aatcccccca aaccaaaggg aaagcctcct   1200

gctcccaaac cagccagtcc caagaagaac attaaaacta ggagtgccca gaagagaaca   1260

aacccgaaaa gagtgtgagc taactagttt ccaaagcgga gacttccgac ttccttacag   1320

gatgaggctg ggcattgcct gggacagcct atgtaaggcc atgtgcccct tgccctaaca   1380

actcactgca gtgctcttca tagacacatc ttgcagcatt tttcttaagg ctatgcttca   1440

gtttttcttt gtaagccatc acaagccata gtggtaggtt tgccctttgg tacagaaggt   1500

gagttaaagc tggtggaaaa ggcttattgc attgcattca gagtaacctg tgtgcatact   1560

ctagaagagt agggaaaata atgcttgtta caattcgacc taatatgtgc attgtaaaat   1620

aaatgccata tttcaaacaa aacacgtaat ttttttacag tatgttttat taccttttga   1680

tatctgttgt tgcaatgtta gtgatgtttt aaaatgtgat gaaaatataa tgtttttaag   1740

aaggaacagt agtggaatga atgttaaaag atctttatgt gtttatggtc tgcagaagga   1800

tttttgtgat gaaaggggat tttttgaaaa attagagaag tagcatatgg aaaattataa   1860

tgtgtttttt taccaatgac ttcagtttct gtttttagct agaaacttaa aaacaaaaat   1920

aataataaag aaaaataaat aaaaaggaga ggcagacaat gtctggattc ctgttttttg   1980

gttacctgat ttccatgatc atgatgcttc ttgtcaacac cctcttaagc agcaccagaa   2040

acagtgagtt tgtctgtacc attaggagtt aggtactaat tagttggcta atgctcaagt   2100

attttatacc cacaagagag gtatgtcact catcttactt cccaggacat ccaccctgag   2160

aataatttga caagcttaaa aatggccttc atgtgagtgc caaattttgt ttttcttcat   2220

ttaaatattt tctttgccta aatacatgtg agaggagtta aatataaatg tacagagagg   2280

aaagttgagt tccacctctg aaatgagaat tacttgacag ttgggatact ttaatcagaa   2340

aaaaagaact tatttgcagc attttatcaa caaatttcat aattgtggac aattggaggc   2400

atttatttta aaaaacaatt ttattggcct tttgctaaca cagtaagcat gtattttata   2460

aggcattcaa taaatgcaca acgcccaaag gaaataaaat cctatctaat cctactctcc   2520

actacacaga ggtaatcact attagtattt tggcatatta ttctccaggt gtttgcttat   2580

gcacttataa aatgatttga acaaataaaa ctaggaacct gtatacatgt gtttcataac   2640

ctgcctcctt tgcttggccc tttattgaga taagttttcc tgtcaagaaa gcagaaacca   2700

tctcatttct aacagctgtg ttatattcca tagtatgcat tactcaacaa actgttgtgc   2760

tattggatac ttaggtggtt tcttcactga caatactgaa taaacatctc accggaattc   2820


<210>  1932
<211>  346
<212>  PRT
<213>  Homosapiens

<400>  1932

Met Phe Leu Ser Ile Leu Val Ala Leu Cys Leu Trp Leu His Leu Ala 
1               5                   10                  15      


Leu Gly Val Arg Gly Ala Pro Cys Glu Ala Val Arg Ile Pro Met Cys 
            20                  25                  30          


Arg His Met Pro Trp Asn Ile Thr Arg Met Pro Asn His Leu His His 
        35                  40                  45              


Ser Thr Gln Glu Asn Ala Ile Leu Ala Ile Glu Gln Tyr Glu Glu Leu 
    50                  55                  60                  


Val Asp Val Asn Cys Ser Ala Val Leu Arg Phe Phe Phe Cys Ala Met 
65                  70                  75                  80  


Tyr Ala Pro Ile Cys Thr Leu Glu Phe Leu His Asp Pro Ile Lys Pro 
                85                  90                  95      


Cys Lys Ser Val Cys Gln Arg Ala Arg Asp Asp Cys Glu Pro Leu Met 
            100                 105                 110         


Lys Met Tyr Asn His Ser Trp Pro Glu Ser Leu Ala Cys Asp Glu Leu 
        115                 120                 125             


Pro Val Tyr Asp Arg Gly Val Cys Ile Ser Pro Glu Ala Ile Val Thr 
    130                 135                 140                 


Asp Leu Pro Glu Asp Val Lys Trp Ile Asp Ile Thr Pro Asp Met Met 
145                 150                 155                 160 


Val Gln Glu Arg Pro Leu Asp Val Asp Cys Lys Arg Leu Ser Pro Asp 
                165                 170                 175     


Arg Cys Lys Cys Lys Lys Val Lys Pro Thr Leu Ala Thr Tyr Leu Ser 
            180                 185                 190         


Lys Asn Tyr Ser Tyr Val Ile His Ala Lys Ile Lys Ala Val Gln Arg 
        195                 200                 205             


Ser Gly Cys Asn Glu Val Thr Thr Val Val Asp Val Lys Glu Ile Phe 
    210                 215                 220                 


Lys Ser Ser Ser Pro Ile Pro Arg Thr Gln Val Pro Leu Ile Thr Asn 
225                 230                 235                 240 


Ser Ser Cys Gln Cys Pro His Ile Leu Pro His Gln Asp Val Leu Ile 
                245                 250                 255     


Met Cys Tyr Glu Trp Arg Ser Arg Met Met Leu Leu Glu Asn Cys Leu 
            260                 265                 270         


Val Glu Lys Trp Arg Asp Gln Leu Ser Lys Arg Ser Ile Gln Trp Glu 
        275                 280                 285             


Glu Arg Leu Gln Glu Gln Arg Arg Thr Val Gln Asp Lys Lys Lys Thr 
    290                 295                 300                 


Ala Gly Arg Thr Ser Arg Ser Asn Pro Pro Lys Pro Lys Gly Lys Pro 
305                 310                 315                 320 


Pro Ala Pro Lys Pro Ala Ser Pro Lys Lys Asn Ile Lys Thr Arg Ser 
                325                 330                 335     


Ala Gln Lys Arg Thr Asn Pro Lys Arg Val 
            340                 345     


<210>  1933
<211>  2614
<212>  DNA
<213>  Homosapiens

<400>  1933
tcccccctct taaaacacga tgcctcccag gatgctagtg gcaccactgc cactgcattt     60

cctgttggca gcagtgagca gtgaaaaccg aagcggcaga aggcagtggc agcaggcagt    120

ggcagcaggc agtggcccag gcagaaatag ctcccgcgcg attcactgga gccttccccg    180

ggccctggtc ccggctaccg ggactcgcgc gtccggatct caaaagcggc agaggccacc    240

gaagggacag gaagcacttt ggtccagacc acactcccgg cacagtgcgg aaagagccgg    300

cgggagccac tctgatcccg gacgcctcag cgcccccttg ggcttgggct tgccctcggg    360

ccggggaagg ctgaccgcga tgccaggacg cgctcccctc cgcaccgtcc cgggcgccct    420

gggtgcctgg ctgctgggcg gcctctgggc ctggaccctg tgcggcctgt gcagcctggg    480

ggcggtggga gccccgcgcc cgtgccaggc gccgcagcag tgggaggggc gccaggttat    540

gtaccagcaa agtagcgggc gcaacagccg cgccctgctc tcctacgacg ggctcaacca    600

gcgcgtgcgg gtgctggacg agaggaaggc gctgatcccc tgcaagagat tatttgaata    660

tattttgctg tataaggatg gagtgatgtt tcagattgac caagccacca agcagtgctc    720

aaagatgacc ctgacacagc cctgggatcc tcttgacatt cctcaaaact ccacctttga    780

agaccagtac tccatcgggg ggcctcagga gcagatcacc gtccaggagt ggtcggacag    840

aaagtcagct agatcctatg aaacctggat tggcatctat acagtcaagg attgctatcc    900

tgtccaggaa acctttacca taaactacag tgtgatattg tctacgcggt tttttgacat    960

ccagctgggt attaaagacc cctcggtgtt tacccctcca agcacgtgcc agatggccca   1020

actggagaag atgagcgaag actgctcctg gtgagcctgt gcatagggaa gcggcagcat   1080

cggatgtcag ccccctgcgg ccccagctgg agatggatat gagactagtc aagatgtgaa   1140

tgctaattgg agagaaatat aattttagga agatgcacat tgatgtgggg ttttgatgtg   1200

tctgattttg actactcaag ctctgtttac agaagaaaat tgaatggcga gggtgtggcc   1260

atatgaactg actagatggc taatatggac actttgggta tttctaatgc ctgttcaggg   1320

ctggttttct gcatgcacgg gtatacacat aatgcagtgc catgcacata gggaagggtc   1380

agtaagagaa gtttgccttg gcagcaagta tttattgttg acattattca gaattagtga   1440

taataaaaag cagagtgatt ttggtcaatt ttattattaa ttcttaaatt ccctgcagag   1500

aatgccccct ttattgctgc accagggttg gcattgctcc cactgagccc tactccaccc   1560

tgtccctgca ctcccttggt tgccaaaaaa atgataactt aaatcccttc cagacttaag   1620

aattttatgg catggcccaa ttgatataaa catttagaag gaaatgaaaa gctaaaatag   1680

gaagtaatta ttcctctaaa gaaacatttt gagcaaggca gtttagagaa tcctaatgtc   1740

tacactggca tagcacgagc catgtaagct tctttttttt ctatgcaaga gtattgatgt   1800

atgtgctgaa tcttcacaga cttgtcaata cacaggcagt attctaaaat agcactgaac   1860

agggagtcag gagactattg tctcctaaac ccaggactag agttccctcg tactgtcact   1920

cctttggtca ttaaatgcac tgggcttgcc cgcactttgg ccttcctaga acactgcttc   1980

ataacctctc tgtctgactt ctgcatctcc ttccaggtca gctcattcac aagagttgct   2040

cccaagcctg gatgagttgc accttgcatc ttgagcatgc atttctcaca ataattatta   2100

agctgtgtga taatttctgc tttcaggaca ctcatccatt atcttggctg tgagctcctt   2160

gggtacgggt accttgtatg tttactttta tatccctagc acaaagcaag tgcctggcac   2220

atagtcagtg ccctaagtat tcgtagagtg aagaatgcca gcctctcttg tccctggttt   2280

ccttatgtgt tgaatgtggt tgagtttgtc cattgctagg gagagacttc cagtaataaa   2340

atttactatt ctagatgctt ctactgttat gttttatctg cccatttatc tttcttagtt   2400

accaggagaa atgtgtgaca cctatattat aatgaaaaca atctcattac ttatagttta   2460

tctatattaa acaaatttaa ttgcatttta aagcattctt tgatactgtt gcttttgcaa   2520

taaatatgga taatcttggt tataagggag ttaaaacaat gctgtaataa ataaagtgtt   2580

tcatgtgatc aaaatcaaaa aaaaaaaaaa aaaa                               2614


<210>  1934
<211>  344
<212>  PRT
<213>  Homosapiens

<400>  1934

Met Pro Pro Arg Met Leu Val Ala Pro Leu Pro Leu His Phe Leu Leu 
1               5                   10                  15      


Ala Ala Val Ser Ser Glu Asn Arg Ser Gly Arg Arg Gln Trp Gln Gln 
            20                  25                  30          


Ala Val Ala Ala Gly Ser Gly Pro Gly Arg Asn Ser Ser Arg Ala Ile 
        35                  40                  45              


His Trp Ser Leu Pro Arg Ala Leu Val Pro Ala Thr Gly Thr Arg Ala 
    50                  55                  60                  


Ser Gly Ser Gln Lys Arg Gln Arg Pro Pro Lys Gly Gln Glu Ala Leu 
65                  70                  75                  80  


Trp Ser Arg Pro His Ser Arg His Ser Ala Glu Arg Ala Gly Gly Ser 
                85                  90                  95      


His Ser Asp Pro Gly Arg Leu Ser Ala Pro Leu Gly Leu Gly Leu Pro 
            100                 105                 110         


Ser Gly Arg Gly Arg Leu Thr Ala Met Pro Gly Arg Ala Pro Leu Arg 
        115                 120                 125             


Thr Val Pro Gly Ala Leu Gly Ala Trp Leu Leu Gly Gly Leu Trp Ala 
    130                 135                 140                 


Trp Thr Leu Cys Gly Leu Cys Ser Leu Gly Ala Val Gly Ala Pro Arg 
145                 150                 155                 160 


Pro Cys Gln Ala Pro Gln Gln Trp Glu Gly Arg Gln Val Met Tyr Gln 
                165                 170                 175     


Gln Ser Ser Gly Arg Asn Ser Arg Ala Leu Leu Ser Tyr Asp Gly Leu 
            180                 185                 190         


Asn Gln Arg Val Arg Val Leu Asp Glu Arg Lys Ala Leu Ile Pro Cys 
        195                 200                 205             


Lys Arg Leu Phe Glu Tyr Ile Leu Leu Tyr Lys Asp Gly Val Met Phe 
    210                 215                 220                 


Gln Ile Asp Gln Ala Thr Lys Gln Cys Ser Lys Met Thr Leu Thr Gln 
225                 230                 235                 240 


Pro Trp Asp Pro Leu Asp Ile Pro Gln Asn Ser Thr Phe Glu Asp Gln 
                245                 250                 255     


Tyr Ser Ile Gly Gly Pro Gln Glu Gln Ile Thr Val Gln Glu Trp Ser 
            260                 265                 270         


Asp Arg Lys Ser Ala Arg Ser Tyr Glu Thr Trp Ile Gly Ile Tyr Thr 
        275                 280                 285             


Val Lys Asp Cys Tyr Pro Val Gln Glu Thr Phe Thr Ile Asn Tyr Ser 
    290                 295                 300                 


Val Ile Leu Ser Thr Arg Phe Phe Asp Ile Gln Leu Gly Ile Lys Asp 
305                 310                 315                 320 


Pro Ser Val Phe Thr Pro Pro Ser Thr Cys Gln Met Ala Gln Leu Glu 
                325                 330                 335     


Lys Met Ser Glu Asp Cys Ser Trp 
            340                 


<210>  1935
<211>  1646
<212>  DNA
<213>  Homosapiens

<400>  1935
gccaagcccc gcccctcagg ccggggcgcg accgcggatc cgcagttccc gggccagcct     60

ggggcggccg gccaggaacc acccgttaag gtgtcttctc tttagggatg gtgaggttgg    120

aaaaaggctc ctgtaaccct cctccaggat gaaccacctg ccagaagaca tggagaacgc    180

tctcaccggg agccagagct cccatgcttc tctgcgcaat atccattcca tcaaccccac    240

acaactcatg gccaggattg agtcctatga aggaagggaa aagaaaggca tatctgatgt    300

caggaggact ttctgtttgt ttgtcacctt tgacctctta ttcgtaacat tactgtggat    360

aatagagtta aatgtgaatg gaggcattga gaacacatta gagaaggagg tgatgcagta    420

tgactactat tcttcatatt ttgatatatt tcttctggca gtttttcgat ttaaagtgtt    480

aatacttgca tatgctgtgt gcagactgcg ccattggtgg gcaatagcgt tgacaacggc    540

agtgaccagt gcctttttac tagcaaaagt gatcctttcg aagcttttct ctcaaggggc    600

ttttggctat gtgctgccca tcatttcatt catccttgcc tggattgaga cgtggttcct    660

ggatttcaaa gtgttacctc aagaagcaga agaagaaaac agactcctga tagttcagga    720

tgcttcagag agggcagcac ttatacctgg tggtctttct gatggtcagt tttattcccc    780

tcctgaatcc gaagcaggat ctgaagaagc tgaagaaaaa caggacagtg agaaaccact    840

tttagaacta tgagtactac ttttgttaaa tgtgaaaaac cctcacagaa agtcatcgag    900

gcaaaaagag gcaggcagtg gagtctccct gtcgacagta aagttgaaat ggtgacgtcc    960

actgctggct ttattgaaca gctaataaag atttatttat tgtaatacct cacagacgtt   1020

gtaccatatc catgcacatt tagttgcctg cctgtggctg gtaaggtaat gtcatgattc   1080

atcctctctt cagtgagact gagcctgatg tgttaacaaa taggtgaaga aagtcttgtg   1140

ctgtattcct aatcaaaaga cttaatatat tgaagtaaca cttttttagt aagcaagata   1200

cctttttatt tcaattcaca gaatggaatt tttttgtttc atgtctcaga tttattttgt   1260

atttcttttt taacactcta catttccctt gttttttaac tcatgcacat gtgctctttg   1320

tacagtttta aaaagtgtaa taaaatctga catgtcaatg tggctagttt tatttttctt   1380

gttttgcatt atgtgtatgg cctgaagtgt tggacttgca aaaggggaag aaaggaattg   1440

cgaatacatg taaaatgtca ccagacattt gtattatttt tatcatgaaa tcatgttttt   1500

ctctgattgt tctgaaatgt tctaaatact cttattttga atgcacaaaa tgacttaaac   1560

cattcatatc atgtttcctt tgcgttcagc caatttcaat taaaatgaac taaattaaaa   1620

aaaaaaaaaa aaaaaaaaaa aaaaaa                                        1646


<210>  1936
<211>  234
<212>  PRT
<213>  Homosapiens

<400>  1936

Met Asn His Leu Pro Glu Asp Met Glu Asn Ala Leu Thr Gly Ser Gln 
1               5                   10                  15      


Ser Ser His Ala Ser Leu Arg Asn Ile His Ser Ile Asn Pro Thr Gln 
            20                  25                  30          


Leu Met Ala Arg Ile Glu Ser Tyr Glu Gly Arg Glu Lys Lys Gly Ile 
        35                  40                  45              


Ser Asp Val Arg Arg Thr Phe Cys Leu Phe Val Thr Phe Asp Leu Leu 
    50                  55                  60                  


Phe Val Thr Leu Leu Trp Ile Ile Glu Leu Asn Val Asn Gly Gly Ile 
65                  70                  75                  80  


Glu Asn Thr Leu Glu Lys Glu Val Met Gln Tyr Asp Tyr Tyr Ser Ser 
                85                  90                  95      


Tyr Phe Asp Ile Phe Leu Leu Ala Val Phe Arg Phe Lys Val Leu Ile 
            100                 105                 110         


Leu Ala Tyr Ala Val Cys Arg Leu Arg His Trp Trp Ala Ile Ala Leu 
        115                 120                 125             


Thr Thr Ala Val Thr Ser Ala Phe Leu Leu Ala Lys Val Ile Leu Ser 
    130                 135                 140                 


Lys Leu Phe Ser Gln Gly Ala Phe Gly Tyr Val Leu Pro Ile Ile Ser 
145                 150                 155                 160 


Phe Ile Leu Ala Trp Ile Glu Thr Trp Phe Leu Asp Phe Lys Val Leu 
                165                 170                 175     


Pro Gln Glu Ala Glu Glu Glu Asn Arg Leu Leu Ile Val Gln Asp Ala 
            180                 185                 190         


Ser Glu Arg Ala Ala Leu Ile Pro Gly Gly Leu Ser Asp Gly Gln Phe 
        195                 200                 205             


Tyr Ser Pro Pro Glu Ser Glu Ala Gly Ser Glu Glu Ala Glu Glu Lys 
    210                 215                 220                 


Gln Asp Ser Glu Lys Pro Leu Leu Glu Leu 
225                 230                 


<210>  1937
<211>  857
<212>  DNA
<213>  Homosapiens

<400>  1937
caagcctgga agaactcgtc atgctctttg tagcgtggtg cttctgttgc tcacaggaca     60

acttgccttt gatgattttc aagagagttg tgctatgatg tggcaaaagt atgcaggaag    120

caggcggtca atgcctctgg gagcaaggat ccttttccac ggtgtgttct atgccggggg    180

ctttgccatt gtgtattacc tcattcaaaa gtttcattcc agggctttat attacaagtt    240

ggcagtggag cagctgcaga gccatcccga ggcacaggaa gctctgggcc ctcctctcaa    300

catccattat ctcaagctca tcgacaggga aaacttcgtg gacattgttg atgccaagtt    360

gaagattcct gtctctggat ccaaatcaga gggccttctc tacgtccact catccagagg    420

tggccccttt cagaggtggc accttgacga ggtcttttta gagctcaagg atggtcagca    480

gattcctgtg ttcaagctca gtggggaaaa cggtgatgaa gtgaaaaagg agtagagacg    540

acccagaaga cccagcttgc ttctagtcca tccttccctc atctctacca tatggccact    600

ggggtggtgg cccatctcag tgacagacac tcctgcaacc cagttttcca gccaccagtg    660

ggatgatggt atgtgccagc acatggtaat tttggtgtaa ttctaacttg ggcacaacaa    720

atgctatttg tcatttttaa actgaatccg aaagaaactc ctattataaa tttaagataa    780

tgtaatgtat ttgaaagtgc tttgtataaa aaagcacatg ataaaaggaa tcagaattaa    840

taaaatgttt gttgatc                                                   857


<210>  1938
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  1938

Met Met Trp Gln Lys Tyr Ala Gly Ser Arg Arg Ser Met Pro Leu Gly 
1               5                   10                  15      


Ala Arg Ile Leu Phe His Gly Val Phe Tyr Ala Gly Gly Phe Ala Ile 
            20                  25                  30          


Val Tyr Tyr Leu Ile Gln Lys Phe His Ser Arg Ala Leu Tyr Tyr Lys 
        35                  40                  45              


Leu Ala Val Glu Gln Leu Gln Ser His Pro Glu Ala Gln Glu Ala Leu 
    50                  55                  60                  


Gly Pro Pro Leu Asn Ile His Tyr Leu Lys Leu Ile Asp Arg Glu Asn 
65                  70                  75                  80  


Phe Val Asp Ile Val Asp Ala Lys Leu Lys Ile Pro Val Ser Gly Ser 
                85                  90                  95      


Lys Ser Glu Gly Leu Leu Tyr Val His Ser Ser Arg Gly Gly Pro Phe 
            100                 105                 110         


Gln Arg Trp His Leu Asp Glu Val Phe Leu Glu Leu Lys Asp Gly Gln 
        115                 120                 125             


Gln Ile Pro Val Phe Lys Leu Ser Gly Glu Asn Gly Asp Glu Val Lys 
    130                 135                 140                 


Lys Glu 
145     


<210>  1939
<211>  1094
<212>  DNA
<213>  Homosapiens

<400>  1939
ccgccccggt ccgcaaagcc ggtggcgccc ggaggctgca cggagagcgg tgcccgcgtc     60

agtgaccgaa ggaagagacc aagatgaatg cagagcccga gaggaagttt ggcgtggtgg    120

tggttggtgt tggccgagcc ggctccgtgc ggatgaggga cttgcggaat ccacaccctt    180

cctcagcgtt cctgaacctg attggcttcg tgtcgagaag ggagctcggg agcattgatg    240

gagtccagca gatttctttg gaggatgctc tttccagcca agaggtggag gtcgcctata    300

tctgcagtga gagctccagc catgaggact acatcaggca gttccttaat gctggcaagc    360

acgtccttgt ggaatacccc atgacactgt cattggcggc cgctcaggaa ctgtgggagc    420

tggctgagca gaaaggaaaa gtcttgcacg aggagcatgt tgaactcttg atggaggaat    480

tcgctttcct gaaaaaagaa gtggtgggga aagacctgct gaaagggtcg ctcctcttca    540

cagctggccc gttggaagaa gagcggtttg gcttccctgc attcagcggc atctctcgcc    600

tgacctggct ggtctccctc tttggggagc tttctcttgt gtctgccact ttggaagagc    660

gaaaggaaga tcagtatatg aaaatgacag tgtgtctgga gacagagaag aaaagtccac    720

tgtcatggat tgaagaaaaa ggacctggtc taaaacgaaa cagatattta agcttccatt    780

tcaagtctgg gtccttggag aatgtgccaa atgtaggagt gaataagaac atatttctga    840

aagatcaaaa tatatttgtc cagaaactct tgggccagtt ctctgagaag gaactggctg    900

ctgaaaagaa acgcatcctg cactgcctgg ggcttgcaga agaaatccag aaatattgct    960

gttcaaggaa gtaagaggag gaggtgatgt agcacttcca agatggcacc agcatttggt   1020

tcttctcaag agttgaccat tatctctatt cttaaaatta aacatgttgg ggaaacaaga   1080

aaaaaaaaaa aaaa                                                     1094


<210>  1940
<211>  296
<212>  PRT
<213>  Homosapiens

<400>  1940

Met Asn Ala Glu Pro Glu Arg Lys Phe Gly Val Val Val Val Gly Val 
1               5                   10                  15      


Gly Arg Ala Gly Ser Val Arg Met Arg Asp Leu Arg Asn Pro His Pro 
            20                  25                  30          


Ser Ser Ala Phe Leu Asn Leu Ile Gly Phe Val Ser Arg Arg Glu Leu 
        35                  40                  45              


Gly Ser Ile Asp Gly Val Gln Gln Ile Ser Leu Glu Asp Ala Leu Ser 
    50                  55                  60                  


Ser Gln Glu Val Glu Val Ala Tyr Ile Cys Ser Glu Ser Ser Ser His 
65                  70                  75                  80  


Glu Asp Tyr Ile Arg Gln Phe Leu Asn Ala Gly Lys His Val Leu Val 
                85                  90                  95      


Glu Tyr Pro Met Thr Leu Ser Leu Ala Ala Ala Gln Glu Leu Trp Glu 
            100                 105                 110         


Leu Ala Glu Gln Lys Gly Lys Val Leu His Glu Glu His Val Glu Leu 
        115                 120                 125             


Leu Met Glu Glu Phe Ala Phe Leu Lys Lys Glu Val Val Gly Lys Asp 
    130                 135                 140                 


Leu Leu Lys Gly Ser Leu Leu Phe Thr Ala Gly Pro Leu Glu Glu Glu 
145                 150                 155                 160 


Arg Phe Gly Phe Pro Ala Phe Ser Gly Ile Ser Arg Leu Thr Trp Leu 
                165                 170                 175     


Val Ser Leu Phe Gly Glu Leu Ser Leu Val Ser Ala Thr Leu Glu Glu 
            180                 185                 190         


Arg Lys Glu Asp Gln Tyr Met Lys Met Thr Val Cys Leu Glu Thr Glu 
        195                 200                 205             


Lys Lys Ser Pro Leu Ser Trp Ile Glu Glu Lys Gly Pro Gly Leu Lys 
    210                 215                 220                 


Arg Asn Arg Tyr Leu Ser Phe His Phe Lys Ser Gly Ser Leu Glu Asn 
225                 230                 235                 240 


Val Pro Asn Val Gly Val Asn Lys Asn Ile Phe Leu Lys Asp Gln Asn 
                245                 250                 255     


Ile Phe Val Gln Lys Leu Leu Gly Gln Phe Ser Glu Lys Glu Leu Ala 
            260                 265                 270         


Ala Glu Lys Lys Arg Ile Leu His Cys Leu Gly Leu Ala Glu Glu Ile 
        275                 280                 285             


Gln Lys Tyr Cys Cys Ser Arg Lys 
    290                 295     


<210>  1941
<211>  667
<212>  DNA
<213>  Homosapiens

<400>  1941
aagatggcgg cctccgtgtg cagcgggttg ctggggccac gggtgctgtc ctggagccga     60

gagctgcctt gcgcttggcg cgccctgcac acctccccgg tctgcgccaa gaaccgggcg    120

gcccgagtac gcgtaagcaa gggggacaag ccggtgacct acgaggaggc acacgcgccg    180

cactacatcg cccaccgtaa aggctggctg tcgctgcaca caggtaacct ggatggagag    240

gaccatgccg cagagcgaac ggtggaggat gttttccttc gcaagttcat gtggggtacc    300

ttcccaggct gcctggctga ccagctggtt ttaaagcgcc ggggtaacca gttggagatc    360

tgtgccgtgg tcctgaggca gttgtctcca cacaagtact acttcctcgt gggctacagt    420

gaaactttgc tgtcctactt ttacaaatgt cctgtgcgac tccacctcca aactgtgccc    480

tcaaaggttg tgtataagta cctctagaac aatccccttt tttccatcaa gctgtagcct    540

gcagagaatg gaaacgtggg aaaggaatgg tatgtggggg aaatgcatcc cctcagagga    600

ctgaggcata gtctctcatc tgctattgaa taaagacctt ctatcttgaa aaaaaaaaaa    660

aaaaaaa                                                              667


<210>  1942
<211>  167
<212>  PRT
<213>  Homosapiens

<400>  1942

Met Ala Ala Ser Val Cys Ser Gly Leu Leu Gly Pro Arg Val Leu Ser 
1               5                   10                  15      


Trp Ser Arg Glu Leu Pro Cys Ala Trp Arg Ala Leu His Thr Ser Pro 
            20                  25                  30          


Val Cys Ala Lys Asn Arg Ala Ala Arg Val Arg Val Ser Lys Gly Asp 
        35                  40                  45              


Lys Pro Val Thr Tyr Glu Glu Ala His Ala Pro His Tyr Ile Ala His 
    50                  55                  60                  


Arg Lys Gly Trp Leu Ser Leu His Thr Gly Asn Leu Asp Gly Glu Asp 
65                  70                  75                  80  


His Ala Ala Glu Arg Thr Val Glu Asp Val Phe Leu Arg Lys Phe Met 
                85                  90                  95      


Trp Gly Thr Phe Pro Gly Cys Leu Ala Asp Gln Leu Val Leu Lys Arg 
            100                 105                 110         


Arg Gly Asn Gln Leu Glu Ile Cys Ala Val Val Leu Arg Gln Leu Ser 
        115                 120                 125             


Pro His Lys Tyr Tyr Phe Leu Val Gly Tyr Ser Glu Thr Leu Leu Ser 
    130                 135                 140                 


Tyr Phe Tyr Lys Cys Pro Val Arg Leu His Leu Gln Thr Val Pro Ser 
145                 150                 155                 160 


Lys Val Val Tyr Lys Tyr Leu 
                165         


<210>  1943
<211>  3606
<212>  DNA
<213>  Homosapiens

<400>  1943
cctcgctgcg ctcatggcgt cgcccgggca ttcagatttg ggagaagtag ccccagaaat     60

aaaagcatca gagagacgaa cagctgtggc cattgcagat ttggaatgga gagaaatgga    120

aggagatgat tgcgagttcc gttatggaga tggtacaaat gaggctcagg acaatgattt    180

tccaacagtg gagagaagca ggcttcaaga aatgctgtca cttttgggcc tagagacgta    240

ccaggtccag aaactcagcc tccaggactc tctgcagatc agttttgaca gtatgaagaa    300

ctgggcccct caggttccca aagacttgcc ctggaatttc ctcaggaagt tgcaggccct    360

caatgctgat gccaggaata ccactatggt gctggacgtg ctcccagacg ccaggcctgt    420

ggagaaggag agccagatgg aagaggagat catctactgg gacccagctg atgaccttgc    480

tgccgacatt tattcctttt ctgagctgcc cacccctgat acgccagtga accccttaga    540

ccttctctgt gccctgctgc tctcctcaga cagtttcctg caacaagaaa tagcgttgaa    600

aatggccctc tgccagtttg cactcccact cgtgttgcct gactcggaga accactacca    660

tacatttctg ctgtgggcca tgcggggcat tgtgaggaca tggtggtccc agcccccaag    720

gggcatgggg agcttccggg aagacagcgt ggtcttgtcc agggcgcccg ccttcgcctt    780

cgtgcgcatg gacgtcagta gcaactccaa gtcccagctt ctcaacgccg tcctcagccc    840

gggccacagg cagtgggact gcttctggca tcgggacctc aacttgggca ccaatgcccg    900

ggagatttcg gatgggttgg tagaaatttc ctggtttttt cccagcggaa gggaggactt    960

ggacattttc ccagaacctg tggcctttct gaacctgaga ggtgacatcg ggtctcactg   1020

gctgcagttt aagctcttga cagaaatctc ctccgctgtg tttatattga ctgacaatat   1080

cagtaagaag gaatacaaat tgctgtactc catgaaggag tcaaccacaa aatactactt   1140

catcctgagt ccctaccgtg ggaagcgcaa cacaaacctg agatttctga ataagttaat   1200

tcctgtgctg aaaatagacc actcacatgt cctggtaaag gtcagcagca ctgacagcga   1260

cagcttcgtg aagaggatcc gggccatcgt tgggaatgtg ctgcgggcac cctgcaggcg   1320

ggtatctgtg gaggacatgg cgcacgcagc ccgcaaactg ggcctaaagg tcgacgagga   1380

ctgtgaggag tgtcagaaag cgaaagaccg gatggagagg attaccagga aaatcaaaga   1440

ctcggatgcc tacagaaggg acgagctgag gctgcagggg gacccctgga gaaaggcagc   1500

ccaagtggag aaggagttct gccagctcca gtgggccgtg gacccccctg agaagcacag   1560

ggctgagctg aggcggcggc tgctagaact tcgaatgcag cagaacggcc atgattcctc   1620

ctcgggggtg caggagttca tctcggggat cagcagcccc tccttgagtg agaagcagta   1680

cttcctgagg tggatggagt ggggcctggc acgggtggcc cagccgcgac tgagacagcc   1740

tccggagacg cttctcaccc tgagaccaaa gcacgggggc accacagacg tgggggagcc   1800

gctctggcct gagcccctag gggtggaaca cttcttgcgg gagatgggac agttttatga   1860

ggctgagagc tgtcttgtgg aggcagggag gctgccggca ggccagaggc gttttgccca   1920

cttcccaggc ttggcctcgg agctgctgct gacagggctg cctctggagc taatcgatgg   1980

gagcacgctg agcatgcccg tccgctgggt cacagggctc ctgaaggagc tgcacgtccg   2040

actggagaga cggtcaaggc tggtggttct gtcaaccgtc ggggtgccag gcacgggcaa   2100

gtccacactc ctcaacacca tgtttgggct gcggtttgcc acagggaaga gctgcggtcc   2160

tcgaggggcc ttcatgcagc tcatcacagt ggctgagggc ttcagccagg acctgggctg   2220

tgaccacatc ctggtgatag actccggggg cttgataggt ggggccttga cgtcagctgg   2280

ggacagattt gagctggagg cttccttggc cactctgctc atgggactga gcaatgtcac   2340

cgtgatcagt ctagctgaaa ccaaggacat tccagcagct attctgcatg catttctgag   2400

gttagaaaaa acggggcaca tgcccaacta ccagtttgta taccagaacc ttcatgatgt   2460

atctgttccc ggccctaggc ccagagacaa gagacagctc ctggatccac ctggtgacct   2520

gagcagggct gcagcccaga tggagaaaca gggcgacggc ttccgggcac tggcaggcct   2580

ggccttctgc gaccctgaga agcagcacat ctggcacatc ccaggcctgt ggcacggagc   2640

acctcccatg gccgcagtga gcttggccta cagtgaagcc atatttgaat tgaagagatg   2700

cctactcgaa aacatcagga acggcttgtc gaaccaaaac aaaaacatcc agcagctcat   2760

tgagctggtg agacggctgt gagtgtgcag agaaacccag ttcaggtgta ggaggctgct   2820

gtgggcagcc ctgtctgatg gggcacccgt gtggggctgt gctctggtgc ctgagaatgg   2880

ctggtgccca atcgacatga gaagacgagc agaagacaga gggtttggag tctcctcaac   2940

agtgttaaaa gaggaagtga cctcacagac cagctcagag atgttaccaa gaatatcaca   3000

gcccccaggg tagggagaca agcagcagtt tgttctgtct cagctcctgt caaggatcct   3060

gcggggtggg ccctctgtat agctgctctc tgtcactggc ccctggagtg ggagcagcgt   3120

ccttagtcac tgcaggccca ggcgggcagg tggtcccagg acagaggtgg ggaagttgtc   3180

ctgaggaagc agaagtaggc cttgctcccg cccaacccaa gggcctccag tggaccagca   3240

ttcaagatgt gagtgcccgt ggtgtgcaag gcactcccat ggcaccgtat ttattgactg   3300

atctgtgaag gcttccctga cccctgccca ggaagagttc actggtcgct ctgttgtgcc   3360

ccacagcact ttgttatacc tctgccacac acttcacgca gcgcgttgta actcatgtgt   3420

ttacatgtct gtccccccag actgtgagct ccttgagggc agggactgta cattctccag   3480

ctctgtgtcc ccagggcctg gcacattgta gacgcttaat aaatgtctgt taaatgaaaa   3540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3600

aaaaaa                                                              3606


<210>  1944
<211>  922
<212>  PRT
<213>  Homosapiens

<400>  1944

Met Ala Ser Pro Gly His Ser Asp Leu Gly Glu Val Ala Pro Glu Ile 
1               5                   10                  15      


Lys Ala Ser Glu Arg Arg Thr Ala Val Ala Ile Ala Asp Leu Glu Trp 
            20                  25                  30          


Arg Glu Met Glu Gly Asp Asp Cys Glu Phe Arg Tyr Gly Asp Gly Thr 
        35                  40                  45              


Asn Glu Ala Gln Asp Asn Asp Phe Pro Thr Val Glu Arg Ser Arg Leu 
    50                  55                  60                  


Gln Glu Met Leu Ser Leu Leu Gly Leu Glu Thr Tyr Gln Val Gln Lys 
65                  70                  75                  80  


Leu Ser Leu Gln Asp Ser Leu Gln Ile Ser Phe Asp Ser Met Lys Asn 
                85                  90                  95      


Trp Ala Pro Gln Val Pro Lys Asp Leu Pro Trp Asn Phe Leu Arg Lys 
            100                 105                 110         


Leu Gln Ala Leu Asn Ala Asp Ala Arg Asn Thr Thr Met Val Leu Asp 
        115                 120                 125             


Val Leu Pro Asp Ala Arg Pro Val Glu Lys Glu Ser Gln Met Glu Glu 
    130                 135                 140                 


Glu Ile Ile Tyr Trp Asp Pro Ala Asp Asp Leu Ala Ala Asp Ile Tyr 
145                 150                 155                 160 


Ser Phe Ser Glu Leu Pro Thr Pro Asp Thr Pro Val Asn Pro Leu Asp 
                165                 170                 175     


Leu Leu Cys Ala Leu Leu Leu Ser Ser Asp Ser Phe Leu Gln Gln Glu 
            180                 185                 190         


Ile Ala Leu Lys Met Ala Leu Cys Gln Phe Ala Leu Pro Leu Val Leu 
        195                 200                 205             


Pro Asp Ser Glu Asn His Tyr His Thr Phe Leu Leu Trp Ala Met Arg 
    210                 215                 220                 


Gly Ile Val Arg Thr Trp Trp Ser Gln Pro Pro Arg Gly Met Gly Ser 
225                 230                 235                 240 


Phe Arg Glu Asp Ser Val Val Leu Ser Arg Ala Pro Ala Phe Ala Phe 
                245                 250                 255     


Val Arg Met Asp Val Ser Ser Asn Ser Lys Ser Gln Leu Leu Asn Ala 
            260                 265                 270         


Val Leu Ser Pro Gly His Arg Gln Trp Asp Cys Phe Trp His Arg Asp 
        275                 280                 285             


Leu Asn Leu Gly Thr Asn Ala Arg Glu Ile Ser Asp Gly Leu Val Glu 
    290                 295                 300                 


Ile Ser Trp Phe Phe Pro Ser Gly Arg Glu Asp Leu Asp Ile Phe Pro 
305                 310                 315                 320 


Glu Pro Val Ala Phe Leu Asn Leu Arg Gly Asp Ile Gly Ser His Trp 
                325                 330                 335     


Leu Gln Phe Lys Leu Leu Thr Glu Ile Ser Ser Ala Val Phe Ile Leu 
            340                 345                 350         


Thr Asp Asn Ile Ser Lys Lys Glu Tyr Lys Leu Leu Tyr Ser Met Lys 
        355                 360                 365             


Glu Ser Thr Thr Lys Tyr Tyr Phe Ile Leu Ser Pro Tyr Arg Gly Lys 
    370                 375                 380                 


Arg Asn Thr Asn Leu Arg Phe Leu Asn Lys Leu Ile Pro Val Leu Lys 
385                 390                 395                 400 


Ile Asp His Ser His Val Leu Val Lys Val Ser Ser Thr Asp Ser Asp 
                405                 410                 415     


Ser Phe Val Lys Arg Ile Arg Ala Ile Val Gly Asn Val Leu Arg Ala 
            420                 425                 430         


Pro Cys Arg Arg Val Ser Val Glu Asp Met Ala His Ala Ala Arg Lys 
        435                 440                 445             


Leu Gly Leu Lys Val Asp Glu Asp Cys Glu Glu Cys Gln Lys Ala Lys 
    450                 455                 460                 


Asp Arg Met Glu Arg Ile Thr Arg Lys Ile Lys Asp Ser Asp Ala Tyr 
465                 470                 475                 480 


Arg Arg Asp Glu Leu Arg Leu Gln Gly Asp Pro Trp Arg Lys Ala Ala 
                485                 490                 495     


Gln Val Glu Lys Glu Phe Cys Gln Leu Gln Trp Ala Val Asp Pro Pro 
            500                 505                 510         


Glu Lys His Arg Ala Glu Leu Arg Arg Arg Leu Leu Glu Leu Arg Met 
        515                 520                 525             


Gln Gln Asn Gly His Asp Ser Ser Ser Gly Val Gln Glu Phe Ile Ser 
    530                 535                 540                 


Gly Ile Ser Ser Pro Ser Leu Ser Glu Lys Gln Tyr Phe Leu Arg Trp 
545                 550                 555                 560 


Met Glu Trp Gly Leu Ala Arg Val Ala Gln Pro Arg Leu Arg Gln Pro 
                565                 570                 575     


Pro Glu Thr Leu Leu Thr Leu Arg Pro Lys His Gly Gly Thr Thr Asp 
            580                 585                 590         


Val Gly Glu Pro Leu Trp Pro Glu Pro Leu Gly Val Glu His Phe Leu 
        595                 600                 605             


Arg Glu Met Gly Gln Phe Tyr Glu Ala Glu Ser Cys Leu Val Glu Ala 
    610                 615                 620                 


Gly Arg Leu Pro Ala Gly Gln Arg Arg Phe Ala His Phe Pro Gly Leu 
625                 630                 635                 640 


Ala Ser Glu Leu Leu Leu Thr Gly Leu Pro Leu Glu Leu Ile Asp Gly 
                645                 650                 655     


Ser Thr Leu Ser Met Pro Val Arg Trp Val Thr Gly Leu Leu Lys Glu 
            660                 665                 670         


Leu His Val Arg Leu Glu Arg Arg Ser Arg Leu Val Val Leu Ser Thr 
        675                 680                 685             


Val Gly Val Pro Gly Thr Gly Lys Ser Thr Leu Leu Asn Thr Met Phe 
    690                 695                 700                 


Gly Leu Arg Phe Ala Thr Gly Lys Ser Cys Gly Pro Arg Gly Ala Phe 
705                 710                 715                 720 


Met Gln Leu Ile Thr Val Ala Glu Gly Phe Ser Gln Asp Leu Gly Cys 
                725                 730                 735     


Asp His Ile Leu Val Ile Asp Ser Gly Gly Leu Ile Gly Gly Ala Leu 
            740                 745                 750         


Thr Ser Ala Gly Asp Arg Phe Glu Leu Glu Ala Ser Leu Ala Thr Leu 
        755                 760                 765             


Leu Met Gly Leu Ser Asn Val Thr Val Ile Ser Leu Ala Glu Thr Lys 
    770                 775                 780                 


Asp Ile Pro Ala Ala Ile Leu His Ala Phe Leu Arg Leu Glu Lys Thr 
785                 790                 795                 800 


Gly His Met Pro Asn Tyr Gln Phe Val Tyr Gln Asn Leu His Asp Val 
                805                 810                 815     


Ser Val Pro Gly Pro Arg Pro Arg Asp Lys Arg Gln Leu Leu Asp Pro 
            820                 825                 830         


Pro Gly Asp Leu Ser Arg Ala Ala Ala Gln Met Glu Lys Gln Gly Asp 
        835                 840                 845             


Gly Phe Arg Ala Leu Ala Gly Leu Ala Phe Cys Asp Pro Glu Lys Gln 
    850                 855                 860                 


His Ile Trp His Ile Pro Gly Leu Trp His Gly Ala Pro Pro Met Ala 
865                 870                 875                 880 


Ala Val Ser Leu Ala Tyr Ser Glu Ala Ile Phe Glu Leu Lys Arg Cys 
                885                 890                 895     


Leu Leu Glu Asn Ile Arg Asn Gly Leu Ser Asn Gln Asn Lys Asn Ile 
            900                 905                 910         


Gln Gln Leu Ile Glu Leu Val Arg Arg Leu 
        915                 920         


<210>  1945
<211>  1398
<212>  DNA
<213>  Homosapiens

<400>  1945
gtgcagcttg gtggcggctg agccggcagc gggccgcctc aggcagcccc ggccgggccg     60

cccgggtccc cggcagcggg gtaggatggc gctaaagcgg atccagaagg aattaaccga    120

cttgcagagg gatcctcctg cccagtgttc tgcaggacct gtcggtgatg acttgttcca    180

ctggcaggcc accatcatgg gcccgaatga cagtccttac caaggaggtg ttttcttcct    240

gaccatccac tttcctacag attacccgtt caagccccca aaggttgctt tcacaaccaa    300

aatttatcac cctaatatca acagcaatgg cagcatctgc cttgatatcc tgcggtctca    360

gtggtctcca gcgttgactg tgtcaaaagt tctcttgtcc atctgctcgc tgctctgcga    420

ccccaacccc gatgaccccc tggtgccaga gatagcacac acctacaagg ccgacagaga    480

gaagtacaac agactagcaa gagagtggac acaaaaatat gctatgtaag tgccttggag    540

gttttacatg agacactgtc caagagaagc tggcagagag gtcttccctt aaaactttgg    600

gctgttggct gagccattca aagagcatca tctgttcttc aaacaaatgt tggtcaccca    660

ctctctccag ctgcagcatg ttggtgccat tttcagcaat tacggctttg acagtgccac    720

ctctttgatg ccaaatcagc aaccattgtt gttatgatct gcagtcttcc tggtgacact    780

ggaatctctc tctctgccgc ctcagtttgt ctgctggtct cttggggggc caggccctgc    840

acgtctctcc tacccggcct caaatggtgc ttctgcccat gatggtacca caccagggcc    900

tcagcctggc ccctcaccac ataccctttg ccttttagaa ctcagtgcca tcctgggtgc    960

ccagggcaga gcaggctttg ttcgcacctc atctgctgca gaaccacatc ctgaggagtc   1020

tcagcttatc ctggagggaa ttgggaacag tgtcactggg aagtgaaggc ctagccctgt   1080

ggcttccacc agtctcctcc tgcagtgcca cgtggtggca tttctcgcct cacaccaaga   1140

agcagcaagt ggaaaatttc aggatacaaa gcacataaca ccccataaga gatgattatg   1200

tttttagaag caagagcaaa attatgaaac ctctagagat ttgggtcatg ttactccatt   1260

tgatgaagat tctcactacc gcccgctcct cccataggag cctacactaa gtccaagtgt   1320

gagccattca cagactagaa cacaaggagg gagagagact cttaaacgta aataaaaatg   1380

caattcactc acaactct                                                 1398


<210>  1946
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  1946

Met Ala Leu Lys Arg Ile Gln Lys Glu Leu Thr Asp Leu Gln Arg Asp 
1               5                   10                  15      


Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Phe His 
            20                  25                  30          


Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
        35                  40                  45              


Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
    50                  55                  60                  


Pro Lys Val Ala Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn Ser 
65                  70                  75                  80  


Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                85                  90                  95      


Leu Thr Val Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
            100                 105                 110         


Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala His Thr Tyr Lys 
        115                 120                 125             


Ala Asp Arg Glu Lys Tyr Asn Arg Leu Ala Arg Glu Trp Thr Gln Lys 
    130                 135                 140                 


Tyr Ala Met 
145         


<210>  1947
<211>  1051
<212>  DNA
<213>  Homosapiens

<400>  1947
agttcaagta attctcctgc ctcagcctcc tgaggagctg ggattacagg catgcgccac     60

cacacctggc tcacagggtg agaccctgtc tctaaaaaca acaacgacaa aaatgacaca    120

atagtgaggg cacaggcccc aggtcactga cttagattct aatcccagct cttccaactg    180

ctgtttcttc acctgctgag cctcagtttc cccatctgtc attggggata ccagcccctg    240

cttcacgggt gcctagggga ttcccaggag attatggagg tgcctcaagg tgcctggtag    300

ggctgagggt ggagggtatg ggggttcagg gccgtgtccc tggctgagct gaccccacag    360

gtttcagcgg gtgggcccac ctgacggagg ttgaccctga tgaggaggtg cagggcgaga    420

tccacctgcg gctggaagtg cgcccagggg cccgggcctg ccagctacgc tgctctgtgc    480

tggaggccag atcatgaaga agtcatgcta cccacgctgg aatgagacgt ttgaatttga    540

gctgcaggag ggggccgtgg aggcgctgtg cgtggaggcc tgggactggg accttgtcag    600

ccgaaacgac ttcctgggca aagtggtgat cgatgtccag agactgcggg tggcgcagca    660

ggaggagggc tggttccggc tgcagcccga ccagtccaag agccggcagc atgacgaggg    720

caacctgggc tccttgcagc tggaggtgcg gctgcgggac gagacggtgc tgccctccag    780

ctactaccag ccactggtgc acctgctgtg ccacgaggtc aagctgggca tgcagggccc    840

agggcagctg atcccactca tcgaggagac aaccagcacc gagtgtcgcc aggacgtggc    900

cacgaacctg ctcaagctct tcctggggca ggggctggcc aaggacttcc tggacctgct    960

cttccagctg gagctgagtc gcaccatttc ctgttggctg tcctgtaacc actcaatggg   1020

ttcttctttc ctgttgctca gatacagctg a                                  1051


<210>  1948
<211>  185
<212>  PRT
<213>  Homosapiens

<400>  1948

Met Lys Lys Ser Cys Tyr Pro Arg Trp Asn Glu Thr Phe Glu Phe Glu 
1               5                   10                  15      


Leu Gln Glu Gly Ala Val Glu Ala Leu Cys Val Glu Ala Trp Asp Trp 
            20                  25                  30          


Asp Leu Val Ser Arg Asn Asp Phe Leu Gly Lys Val Val Ile Asp Val 
        35                  40                  45              


Gln Arg Leu Arg Val Ala Gln Gln Glu Glu Gly Trp Phe Arg Leu Gln 
    50                  55                  60                  


Pro Asp Gln Ser Lys Ser Arg Gln His Asp Glu Gly Asn Leu Gly Ser 
65                  70                  75                  80  


Leu Gln Leu Glu Val Arg Leu Arg Asp Glu Thr Val Leu Pro Ser Ser 
                85                  90                  95      


Tyr Tyr Gln Pro Leu Val His Leu Leu Cys His Glu Val Lys Leu Gly 
            100                 105                 110         


Met Gln Gly Pro Gly Gln Leu Ile Pro Leu Ile Glu Glu Thr Thr Ser 
        115                 120                 125             


Thr Glu Cys Arg Gln Asp Val Ala Thr Asn Leu Leu Lys Leu Phe Leu 
    130                 135                 140                 


Gly Gln Gly Leu Ala Lys Asp Phe Leu Asp Leu Leu Phe Gln Leu Glu 
145                 150                 155                 160 


Leu Ser Arg Thr Ile Ser Cys Trp Leu Ser Cys Asn His Ser Met Gly 
                165                 170                 175     


Ser Ser Phe Leu Leu Leu Arg Tyr Ser 
            180                 185 


<210>  1949
<211>  2691
<212>  DNA
<213>  Homosapiens

<400>  1949
ggggagggga aggagcggca catggggttg agcagaggag aaaatcagaa agatggctta     60

gagaagtcag cagtctgcga gtctggggag gatggagagt ggtttggggt tttgggtcgg    120

ggtctaaggt gatcagatgc agaagcatta cacagtggcc tggtttcttt actcagcccc    180

tggggtagat cccagccccc catgtaggtc ccttggctgg aaaaggaaga gggagtggtc    240

agatgaatct gaggaggagc cggagaagga gctcgcccct gagcctgagg agacctgggt    300

agtggagacg ctgtgtgggc tcaagatgaa gctgaagcaa cagcgagtgt cacccatcct    360

ccttgagcac cacaaggact tcaacagtca gcttgcccct ggggtagatc ccagcccccc    420

gcataggtcc ttttgctgga aaaggaagat ggagtggtgg gacaaatctg aggagtcgga    480

ggaggagcca cggaaggtgc tcgcccctga gcctgaggag atctgggtgg cggagatgct    540

gtgtggcctc aagatgaagc tgaagcgacg gcgagtgtcg ctcgtgctcc ctgagcacca    600

cgaggccttc aacaggctgc ttgaggatcc tgtcattaaa agattcctgg cctgggacaa    660

agatctgagg gtgtcggaca agtatctcct tgctatggtc atagcgtatt tcagccgagc    720

cggcttcccc tcctggcaat accaacgcct tcatttcttc ctggctctct acctggccaa    780

tgacatggag gaggacgacg aggactccaa acaaaacatc ttccacttcc tgtatgggaa    840

gaaccgctct cgcataccct tgctccgtaa gcgtcggttc cagttatacc gttccatgaa    900

cccgagggcc aggaagaacc gctctcacat acccttggtc cgtaagcgtc ggttccagtt    960

acgccgttgc atgaacccga gggccaggaa gaaccgctct cagatagtcc tgttccagaa   1020

acgtcggttc cacttcttct gttccatgag ctgcagggct tgggtttccc cagaggagtt   1080

ggaggagatc caggcttatg acccagagca ctgggtgtgg gcgcgagatc gcgctcgcct   1140

ttcctagagc tccagggacc gtggaggcct gaggtcatcg gcctgagaga agaacaccgg   1200

acccagggga gatgtggatt ttcagcagga actttattcc aatgctaatg gcagacacca   1260

ggaaggagga gaggaaccat ttgtgcagat catctagaag aacctggacc attcttgatg   1320

gagctgaata cagtgatcac gttgtcctcc taggagcagg ggtgggggga gggggatggg   1380

gtccttctag gagtccttgg agaaaagtaa gaaaccagga gtgtttccag ttccaccctt   1440

tcctggggca ccaccaccct ttttatattg ctgaattcca acctccctgg ggcggaacct   1500

ggaggtcctg tttcttacgg acttggttgc cacagtccag gagcatttga aggcacaatg   1560

caggggctca gattggcaca gaattctttt gtgaaatatc agtgccacag attgtaacag   1620

atagcttcat gcacactctg cattttattg gtttgtttgg aaaatgttgg ccattgaatt   1680

attcatagat ttatttcaaa tagtttggaa attgttgtac ttttgaaaac atgctgttcc   1740

tgtagttttt tgatgagagt tatagttgtt atatatacat aaagataatt ttcttttcat   1800

ttttgagaca attcttttta tcctaaatat tttatcatct ttaaatttgt ttctgtatta   1860

ttatatgtgc tcctgaagcg agcactcttt ttatctatga tacttccata ataatctctt   1920

ctatttatag ctattggtag ttcccctaaa ttctgacgat agaaattttt atttgctgtt   1980

taggtttgtg actgaattgt gagaattcag ttgtgatttt taacatgtgt cagatatata   2040

tactaacacg tctaatatat actattttat tggtttattt tgaaaaacat gggtatagaa   2100

ttatttaaat attattttat ttatttaaat atttattaaa tatatttatt tatttaaatg   2160

ttattattac tttaaatatt attttaaata ttttggaaat actggtattt ttgaatagat   2220

gctgtttcta taaagctgtg tgatggtatt ataactgtta tatacacata catataattt   2280

tgttttcctt tttaagagag gattcttttc atcctaaatc ttttaccttt caatctttgt   2340

atctattatt acacgtgctg ctgaagggag catggttttt atctatgata cttagttaac   2400

atatatatta catttatagc tatgtagtag ttcccctaaa ttcttgtaaa aataaatttt   2460

tatttgatat ttcatctatg tttgaaatgt gagaattcag atgtaatttt ttaccttgat   2520

ttggcatgtt tgtatgttac tttaaagagg atgtgtgttc taaaggagga catgagctgt   2580

gtgttttcaa gagaacaata gagtgtgtct cttggggaaa cgtaataaaa atgaactttt   2640

ctcaccttca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a            2691


<210>  1950
<211>  336
<212>  PRT
<213>  Homosapiens

<400>  1950

Met Gln Lys His Tyr Thr Val Ala Trp Phe Leu Tyr Ser Ala Pro Gly 
1               5                   10                  15      


Val Asp Pro Ser Pro Pro Cys Arg Ser Leu Gly Trp Lys Arg Lys Arg 
            20                  25                  30          


Glu Trp Ser Asp Glu Ser Glu Glu Glu Pro Glu Lys Glu Leu Ala Pro 
        35                  40                  45              


Glu Pro Glu Glu Thr Trp Val Val Glu Thr Leu Cys Gly Leu Lys Met 
    50                  55                  60                  


Lys Leu Lys Gln Gln Arg Val Ser Pro Ile Leu Leu Glu His His Lys 
65                  70                  75                  80  


Asp Phe Asn Ser Gln Leu Ala Pro Gly Val Asp Pro Ser Pro Pro His 
                85                  90                  95      


Arg Ser Phe Cys Trp Lys Arg Lys Met Glu Trp Trp Asp Lys Ser Glu 
            100                 105                 110         


Glu Ser Glu Glu Glu Pro Arg Lys Val Leu Ala Pro Glu Pro Glu Glu 
        115                 120                 125             


Ile Trp Val Ala Glu Met Leu Cys Gly Leu Lys Met Lys Leu Lys Arg 
    130                 135                 140                 


Arg Arg Val Ser Leu Val Leu Pro Glu His His Glu Ala Phe Asn Arg 
145                 150                 155                 160 


Leu Leu Glu Asp Pro Val Ile Lys Arg Phe Leu Ala Trp Asp Lys Asp 
                165                 170                 175     


Leu Arg Val Ser Asp Lys Tyr Leu Leu Ala Met Val Ile Ala Tyr Phe 
            180                 185                 190         


Ser Arg Ala Gly Phe Pro Ser Trp Gln Tyr Gln Arg Leu His Phe Phe 
        195                 200                 205             


Leu Ala Leu Tyr Leu Ala Asn Asp Met Glu Glu Asp Asp Glu Asp Ser 
    210                 215                 220                 


Lys Gln Asn Ile Phe His Phe Leu Tyr Gly Lys Asn Arg Ser Arg Ile 
225                 230                 235                 240 


Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu Tyr Arg Ser Met Asn Pro 
                245                 250                 255     


Arg Ala Arg Lys Asn Arg Ser His Ile Pro Leu Val Arg Lys Arg Arg 
            260                 265                 270         


Phe Gln Leu Arg Arg Cys Met Asn Pro Arg Ala Arg Lys Asn Arg Ser 
        275                 280                 285             


Gln Ile Val Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys Ser Met 
    290                 295                 300                 


Ser Cys Arg Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Ile Gln Ala 
305                 310                 315                 320 


Tyr Asp Pro Glu His Trp Val Trp Ala Arg Asp Arg Ala Arg Leu Ser 
                325                 330                 335     


<210>  1951
<211>  3751
<212>  DNA
<213>  Homosapiens

<400>  1951
cccccaaaag aatgtgtgtg tgattaaaat ttaagttaga gacagtctca ctatgttgcc     60

caggctggtc tcaaactcct ggcctcaagt gatcctcctg cctcggcctc ccaaagtgct    120

aggattacaa gggctaagaa ttctagtcat tcattcactc actcattcat tcattcatga    180

ataaacagtt tgccctgctt gtgtacctgt ccccctcctg ggcggatacg gcaggcaaac    240

ggtgcaaggg cggctgccgg gagaaggtgg gcagctggag tgggactggg ggagacagga    300

tcaatgtgac ctgcggtggt ccccaggtgg ccgggatgca gtacctgcac ggcgtcctgg    360

gccccatcat caacaaggtg tttgaggaga agtacgtgga gctggacccc agcaaagtgg    420

aagttaagga tgtagggtgt tccgggctgc accgcccgca gaccgaggcc gaggtgctgg    480

agcagagcgc gcagacgctg cgcgcccacc tgggggccct gctgagcgcg ctcagccgct    540

cggttcccgc gtgccccgcc gtggtgcgcg ccaccttccg ccagctcttc cggcgcgtgc    600

gcgagcgctt ccccggcgcc cagcacgaga atgtaccgtt catcgccgtc accagcttcc    660

tgtgcctgcg cttcttctct cccgccatca tgtcgcccaa gctcttccac ctgcgggagc    720

gccacgcgga cgcccgcacc agccgcaccc tgctcctgtt ggccaaggca gtccagaacg    780

tgggcaacat ggacacgccg gcttccaggg ccaaggaggc ttggatggag ccgctgcagc    840

ccaccgtgcg ccagggcgtg gcgcagctga aggacttcat caccaagctc gtggacatcg    900

aggagaagga cgagctggac ctgcagcgga cgctgagttt gcaggcgcca cctgtgaagg    960

aggggccact cttcatccac aggaccaagg gcaagggccc cctcatgtcc tcctccttca   1020

agaagctcta cttctccctc actaccgagg ccctcagctt cgcgaagacg cccagctcca   1080

agaaaagcgc cctcatcaag ttagccaaca tccgggcagc agaaaaggtt gaggaaaaga   1140

actttggcag ctcgcacgtc atgcaggtca tctacacgga cgacgccggc aggccccaga   1200

ctgcctacct gcagtgcaag tgtgtgaatg agcttaacca gtggctgtct gtgctgcgga   1260

aggtgagcat caacaacacc ggactgctgg gctcctacca ccctggcatc ttctgtgggg   1320

acaagtggag ctgctgccac caaaaagaga agacaggtca gggctgcgat aagacccggt   1380

cacgggtgac cctgcaggag tggaatgacc ctcttgacca tgaccttgag gcccagctca   1440

tctaccggca cctgctgggc gtggaggcca tgctgtggga gaggcaccgg gagctgagcg   1500

ggggtgcaga ggcaggcacg gtgcccacga gccctggcaa agtccccgag gactcattgg   1560

cccggctgct ccgggtgctg caggacctcc gcgaggccca tagctccagc ccggccggct   1620

ccccaccctc agagcccaac tgcctcctgg agctgcagac gtgaggcccg ccctacgctc   1680

ccttgctgag tcccctgcca agcgctcgga gcccctccag gacactctgc accccctcac   1740

cccggtcctc ctcattaggg tgcagggcct aggtctcttc caagtggggg aggggggaga   1800

gtcaggaata aggggatccc cagaagtgca gagctgagca ggcttgggcc tgtcatggct   1860

ggcctgaagt gtccccagct ccctacagcc gctgtagcca tcactgcctc tccagggacc   1920

ctcctctcct gcctaggaca gacccagcca gaaccactgc taggatgggc cacacccagg   1980

ggtctggcct ccagggacct agagaatggg agggagaacg gggccccagg agacccggcc   2040

gccaccccac ccgctaccct tgggtgccac agggctgtgc tgttgccaac agtaaacctg   2100

ctgttactgt ccaggctctg gggtcttgtg atgagggtct ggggagaaag tgggcccggg   2160

gggaccccgg aggctgtcgg tggatgtgcc gatgatgggg ctgacagtat gggctctggg   2220

catccctgtt cccccctctt tcttcccccc actcttctgg ggtcgggggt tcctttccct   2280

tcccagttgc tgtccctggg tcccctcttt catgtcccac aggccacaga gcccagtgtg   2340

tccaaccagc tgttctctcc tcaaagcagc ccccaagcaa gtcccttctc tagggtgtcc   2400

ctgaggacag cacagatgcg ggactcagag accccattcc tcttcacgca gcccttaccc   2460

caagccctct agctgtgtgg ctggcagtgt tggccacgta ggggctccca tccccccacc   2520

attgtgtcac ataggctgcc aggctcagct cccagctgcg tccacagtga cctggatcag   2580

ggtggggaca aggactggac cctccttctc cagaaggcct tcagctcttg ccttgccatg   2640

cagtcacctc cttccccctc tgaccccaga tcccaaaggt gcaccgttgc cccagcccct   2700

ttctggcccc atggggtttc tctgatgcct tcatcataga ggcccggggc tggtccgatg   2760

gttggcaaaa cttgactccg gcccagtccc cactcttggg gacttagaac ccctggtgtc   2820

ctgggatctg gcctgccttt ctttggtcag tccctgtggt cccccaccag ctccccctcc   2880

catagggctg cccaccaagc cctgccccca gcccaagagg agcccccact gcctgcgggg   2940

cagtgatgtc tggccaccgg ctcacaccaa tgacttggtc ctggggtggc agaagcagca   3000

ggtgacagga gcagggcccc tgtccctctc ttctggccct gtggtaccca ggccacacgt   3060

tgtgcccgct cttagggctg accggctgca gggaccacca gccgctgcta ctgtgggccg   3120

ccccggggca gggtgggcag ggcttttgtg ggttatgagg acacagaagt ccctgaggcc   3180

cccagacctg gcacagccaa cctccttcct cccccggttg cccccaactc taaagcctcc   3240

tccctcccag tgtccactgg ctccaggctc ctcacaacag cagctcatag acacagggcg   3300

tctccaggtg tcccagccct ccagatgttt ctagctctcc agatgggcgc tgttttcacg   3360

tctgcctgca tccattcatt ccttcattcc tcacctttat cctgttatct ctattttttt   3420

aagctaccag gaaggaaagg gaagaagaga tcacgaaact gggaccccca gaagggagga   3480

gtgggctttg aacttagaca tctacctcag agctcaaata ggttgtttaa aatcacattc   3540

aattttcaga tgaaggggaa ctttatagtt ttttttgttt gtttgttttt ttgagacaga   3600

gtctcactct gttgcccagg ctggagtgca aatggcttga tcttggttca ctgcaacctc   3660

tgcctcccag gttcaagcaa ttctcttgcc tcagcctccc gagtagctgg gactacaggc   3720

gtgtgccacc acgcccagct aattcttgta t                                  3751


<210>  1952
<211>  495
<212>  PRT
<213>  Homosapiens

<400>  1952

Met Asn Lys Gln Phe Ala Leu Leu Val Tyr Leu Ser Pro Ser Trp Ala 
1               5                   10                  15      


Asp Thr Ala Gly Lys Arg Cys Lys Gly Gly Cys Arg Glu Lys Val Gly 
            20                  25                  30          


Ser Trp Ser Gly Thr Gly Gly Asp Arg Ile Asn Val Thr Cys Gly Gly 
        35                  40                  45              


Pro Gln Val Ala Gly Met Gln Tyr Leu His Gly Val Leu Gly Pro Ile 
    50                  55                  60                  


Ile Asn Lys Val Phe Glu Glu Lys Tyr Val Glu Leu Asp Pro Ser Lys 
65                  70                  75                  80  


Val Glu Val Lys Asp Val Gly Cys Ser Gly Leu His Arg Pro Gln Thr 
                85                  90                  95      


Glu Ala Glu Val Leu Glu Gln Ser Ala Gln Thr Leu Arg Ala His Leu 
            100                 105                 110         


Gly Ala Leu Leu Ser Ala Leu Ser Arg Ser Val Pro Ala Cys Pro Ala 
        115                 120                 125             


Val Val Arg Ala Thr Phe Arg Gln Leu Phe Arg Arg Val Arg Glu Arg 
    130                 135                 140                 


Phe Pro Gly Ala Gln His Glu Asn Val Pro Phe Ile Ala Val Thr Ser 
145                 150                 155                 160 


Phe Leu Cys Leu Arg Phe Phe Ser Pro Ala Ile Met Ser Pro Lys Leu 
                165                 170                 175     


Phe His Leu Arg Glu Arg His Ala Asp Ala Arg Thr Ser Arg Thr Leu 
            180                 185                 190         


Leu Leu Leu Ala Lys Ala Val Gln Asn Val Gly Asn Met Asp Thr Pro 
        195                 200                 205             


Ala Ser Arg Ala Lys Glu Ala Trp Met Glu Pro Leu Gln Pro Thr Val 
    210                 215                 220                 


Arg Gln Gly Val Ala Gln Leu Lys Asp Phe Ile Thr Lys Leu Val Asp 
225                 230                 235                 240 


Ile Glu Glu Lys Asp Glu Leu Asp Leu Gln Arg Thr Leu Ser Leu Gln 
                245                 250                 255     


Ala Pro Pro Val Lys Glu Gly Pro Leu Phe Ile His Arg Thr Lys Gly 
            260                 265                 270         


Lys Gly Pro Leu Met Ser Ser Ser Phe Lys Lys Leu Tyr Phe Ser Leu 
        275                 280                 285             


Thr Thr Glu Ala Leu Ser Phe Ala Lys Thr Pro Ser Ser Lys Lys Ser 
    290                 295                 300                 


Ala Leu Ile Lys Leu Ala Asn Ile Arg Ala Ala Glu Lys Val Glu Glu 
305                 310                 315                 320 


Lys Asn Phe Gly Ser Ser His Val Met Gln Val Ile Tyr Thr Asp Asp 
                325                 330                 335     


Ala Gly Arg Pro Gln Thr Ala Tyr Leu Gln Cys Lys Cys Val Asn Glu 
            340                 345                 350         


Leu Asn Gln Trp Leu Ser Val Leu Arg Lys Val Ser Ile Asn Asn Thr 
        355                 360                 365             


Gly Leu Leu Gly Ser Tyr His Pro Gly Ile Phe Cys Gly Asp Lys Trp 
    370                 375                 380                 


Ser Cys Cys His Gln Lys Glu Lys Thr Gly Gln Gly Cys Asp Lys Thr 
385                 390                 395                 400 


Arg Ser Arg Val Thr Leu Gln Glu Trp Asn Asp Pro Leu Asp His Asp 
                405                 410                 415     


Leu Glu Ala Gln Leu Ile Tyr Arg His Leu Leu Gly Val Glu Ala Met 
            420                 425                 430         


Leu Trp Glu Arg His Arg Glu Leu Ser Gly Gly Ala Glu Ala Gly Thr 
        435                 440                 445             


Val Pro Thr Ser Pro Gly Lys Val Pro Glu Asp Ser Leu Ala Arg Leu 
    450                 455                 460                 


Leu Arg Val Leu Gln Asp Leu Arg Glu Ala His Ser Ser Ser Pro Ala 
465                 470                 475                 480 


Gly Ser Pro Pro Ser Glu Pro Asn Cys Leu Leu Glu Leu Gln Thr 
                485                 490                 495 


<210>  1953
<211>  2860
<212>  DNA
<213>  Homosapiens

<400>  1953
gatcactgga ggccaggagt ttgagaacag cctggccaat gtagcaagac cccatctcta     60

aaaaaaagaa attagccagc catgatggca ttataggagt gagccactgg gattatagga    120

gtgagccact gcacctgctc tccaggccat gcgcccgggc atgggtcatg ttccactgga    180

ggaagggcag cttctcctaa ttcactcaaa gctgctgggt tggtatggtg gggaacatgg    240

tgtctggcat ggtacaggag ctccgggtta ggagggcttc ctggaggagg tgacgtctga    300

acaggcctcc ccctctgtgt cccctgcagt gtgtgaatga gcttaaccag tggctgtctg    360

tgctgcggaa ggtgagcatc aacaacaccg gactgctggg ctcctaccac cctggcatct    420

tctgtgggga caagtggagc tgctgccacc aaaaagagaa gacaggtcag ggctgcgata    480

agacccggtc acgggtgacc ctgcaggagt ggaatgaccc tcttgaccat gaccttgagg    540

cccagctcat ctaccggcac ctgctgggcg tggaggccat gctgtgggag aggcaccggg    600

agctgagcgg gggtgcagag gcaggcacgg tgcccacgag ccctggcaaa gtccccgagg    660

actcattggc ccggctgctc cgggtgctgc aggacctccg cgaggcccat agctccagcc    720

cggccggctc cccaccctca gagcccaact gcctcctgga gctgcagacg tgaggcccgc    780

cctacgctcc cttgctgagt cccctgccaa gcgctcggag cccctccagg acactctgca    840

ccccctcacc ccggtcctcc tcattagggt gcagggccta ggtctcttcc aagtggggga    900

ggggggagag tcaggaataa ggggatcccc agaagtgcag agctgagcag gcttgggcct    960

gtcatggctg gcctgaagtg tccccagctc cctacagccg ctgtagccat cactgcctct   1020

ccagggaccc tcctctcctg cctaggacag acccagccag aaccactgct aggatgggcc   1080

acacccaggg gtctggcctc cagggaccta gagaatggga gggagaacgg ggccccagga   1140

gacccggccg ccaccccacc cgctaccctt gggtgccaca gggctgtgct gttgccaaca   1200

gtaaacctgc tgttactgtc caggctctgg ggtcttgtga tgagggtctg gggagaaagt   1260

gggcccgggg ggaccccgga ggctgtcggt ggatgtgccg atgatggggc tgacagtatg   1320

ggctctgggc atccctgttc ccccctcttt cttcccccca ctcttctggg gtcgggggtt   1380

cctttccctt cccagttgct gtccctgggt cccctctttc atgtcccaca ggccacagag   1440

cccagtgtgt ccaaccagct gttctctcct caaagcagcc cccaagcaag tcccttctct   1500

agggtgtccc tgaggacagc acagatgcgg gactcagaga ccccattcct cttcacgcag   1560

cccttacccc aagccctcta gctgtgtggc tggcagtgtt ggccacgtag gggctcccat   1620

ccccccacca ttgtgtcaca taggctgcca ggctcagctc ccagctgcgt ccacagtgac   1680

ctggatcagg gtggggacaa ggactggacc ctccttctcc agaaggcctt cagctcttgc   1740

cttgccatgc agtcacctcc ttccccctct gaccccagat cccaaaggtg caccgttgcc   1800

ccagcccctt tctggcccca tggggtttct ctgatgcctt catcatagag gcccggggct   1860

ggtccgatgg ttggcaaaac ttgactccgg cccagtcccc actcttgggg acttagaacc   1920

cctggtgtcc tgggatctgg cctgcctttc tttggtcagt ccctgtggtc ccccaccagc   1980

tccccctccc atagggctgc ccaccaagcc ctgcccccag cccaagagga gcccccactg   2040

cctgcggggc agtgatgtct ggccaccggc tcacaccaat gacttggtcc tggggtggca   2100

gaagcagcag gtgacaggag cagggcccct gtccctctct tctggccctg tggtacccag   2160

gccacacgtt gtgcccgctc ttagggctga ccggctgcag ggaccaccag ccgctgctac   2220

tgtgggccgc cccggggcag ggtgggcagg gcttttgtgg gttatgagga cacagaagtc   2280

cctgaggccc ccagacctgg cacagccaac ctccttcctc ccccggttgc ccccaactct   2340

aaagcctcct ccctcccagt gtccactggc tccaggctcc tcacaacagc agctcataga   2400

cacagggcgt ctccaggtgt cccagccctc cagatgtttc tagctctcca gatgggcgct   2460

gttttcacgt ctgcctgcat ccattcattc cttcattcct cacctttatc ctgttatctc   2520

tattttttta agctaccagg aaggaaaggg aagaagagat cacgaaactg ggacccccag   2580

aagggaggag tgggctttga acttagacat ctacctcaga gctcaaatag gttgtttaaa   2640

atcacattca attttcagat gaaggggaac tttatagttt tttttgtttg tttgtttttt   2700

tgagacagag tctcactctg ttgcccaggc tggagtgcaa atggcttgat cttggttcac   2760

tgcaacctct gcctcccagg ttcaagcaat tctcttgcct cagcctcccg agtagctggg   2820

actacaggcg tgtgccacca cgcccagcta attcttgtat                         2860


<210>  1954
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  1954

Met Leu Trp Glu Arg His Arg Glu Leu Ser Gly Gly Ala Glu Ala Gly 
1               5                   10                  15      


Thr Val Pro Thr Ser Pro Gly Lys Val Pro Glu Asp Ser Leu Ala Arg 
            20                  25                  30          


Leu Leu Arg Val Leu Gln Asp Leu Arg Glu Ala His Ser Ser Ser Pro 
        35                  40                  45              


Ala Gly Ser Pro Pro Ser Glu Pro Asn Cys Leu Leu Glu Leu Gln Thr 
    50                  55                  60                  


<210>  1955
<211>  2815
<212>  DNA
<213>  Homosapiens

<400>  1955
tcttccaggc ttgaccgtcc tggcctgtgg ggaggaagtc acagacctgt ccctctgtgc     60

ccttccctct aggagttccc ttttgtgtca gggtccagag ccactgggaa aagtagtgat    120

atcagggcca ccaaatatat ttggcgggtt ctggaatacc tacgagcgtg gccaaggggc    180

cagcggcggc tgaaatccag cccacaccag cctcctgggc tcctaccatc ccggtgcctt    240

ccgtggggac aagtggagct gttgccacca aaaagacaag acagtgtgtg aatgagctta    300

accagtggct gtctgtgctg cggaaggtga gcatcaacaa caccggactg ctgggctcct    360

accaccctgg catcttctgt ggggacaagt ggagctgctg ccaccaaaaa gagaagacag    420

gtcagggctg cgataagacc cggtcacggg tgaccctgca ggagtggaat gaccctcttg    480

accatgacct tgaggcccag ctcatctacc ggcacctgct gggcgtggag gccatgctgt    540

gggagaggca ccgggagctg agcgggggtg cagaggcagg cacggtgccc acgagccctg    600

gcaaagtccc cgaggactca ttggcccggc tgctccgggt gctgcaggac ctccgcgagg    660

cccatagctc cagcccggcc ggctccccac cctcagagcc caactgcctc ctggagctgc    720

agacgtgagg cccgccctac gctcccttgc tgagtcccct gccaagcgct cggagcccct    780

ccaggacact ctgcaccccc tcaccccggt cctcctcatt agggtgcagg gcctaggtct    840

cttccaagtg ggggaggggg gagagtcagg aataagggga tccccagaag tgcagagctg    900

agcaggcttg ggcctgtcat ggctggcctg aagtgtcccc agctccctac agccgctgta    960

gccatcactg cctctccagg gaccctcctc tcctgcctag gacagaccca gccagaacca   1020

ctgctaggat gggccacacc caggggtctg gcctccaggg acctagagaa tgggagggag   1080

aacggggccc caggagaccc ggccgccacc ccacccgcta cccttgggtg ccacagggct   1140

gtgctgttgc caacagtaaa cctgctgtta ctgtccaggc tctggggtct tgtgatgagg   1200

gtctggggag aaagtgggcc cggggggacc ccggaggctg tcggtggatg tgccgatgat   1260

ggggctgaca gtatgggctc tgggcatccc tgttcccccc tctttcttcc ccccactctt   1320

ctggggtcgg gggttccttt cccttcccag ttgctgtccc tgggtcccct ctttcatgtc   1380

ccacaggcca cagagcccag tgtgtccaac cagctgttct ctcctcaaag cagcccccaa   1440

gcaagtccct tctctagggt gtccctgagg acagcacaga tgcgggactc agagacccca   1500

ttcctcttca cgcagccctt accccaagcc ctctagctgt gtggctggca gtgttggcca   1560

cgtaggggct cccatccccc caccattgtg tcacataggc tgccaggctc agctcccagc   1620

tgcgtccaca gtgacctgga tcagggtggg gacaaggact ggaccctcct tctccagaag   1680

gccttcagct cttgccttgc catgcagtca cctccttccc cctctgaccc cagatcccaa   1740

aggtgcaccg ttgccccagc ccctttctgg ccccatgggg tttctctgat gccttcatca   1800

tagaggcccg gggctggtcc gatggttggc aaaacttgac tccggcccag tccccactct   1860

tggggactta gaacccctgg tgtcctggga tctggcctgc ctttctttgg tcagtccctg   1920

tggtccccca ccagctcccc ctcccatagg gctgcccacc aagccctgcc cccagcccaa   1980

gaggagcccc cactgcctgc ggggcagtga tgtctggcca ccggctcaca ccaatgactt   2040

ggtcctgggg tggcagaagc agcaggtgac aggagcaggg cccctgtccc tctcttctgg   2100

ccctgtggta cccaggccac acgttgtgcc cgctcttagg gctgaccggc tgcagggacc   2160

accagccgct gctactgtgg gccgccccgg ggcagggtgg gcagggcttt tgtgggttat   2220

gaggacacag aagtccctga ggcccccaga cctggcacag ccaacctcct tcctcccccg   2280

gttgccccca actctaaagc ctcctccctc ccagtgtcca ctggctccag gctcctcaca   2340

acagcagctc atagacacag ggcgtctcca ggtgtcccag ccctccagat gtttctagct   2400

ctccagatgg gcgctgtttt cacgtctgcc tgcatccatt cattccttca ttcctcacct   2460

ttatcctgtt atctctattt ttttaagcta ccaggaagga aagggaagaa gagatcacga   2520

aactgggacc cccagaaggg aggagtgggc tttgaactta gacatctacc tcagagctca   2580

aataggttgt ttaaaatcac attcaatttt cagatgaagg ggaactttat agtttttttt   2640

gtttgtttgt ttttttgaga cagagtctca ctctgttgcc caggctggag tgcaaatggc   2700

ttgatcttgg ttcactgcaa cctctgcctc ccaggttcaa gcaattctct tgcctcagcc   2760

tcccgagtag ctgggactac aggcgtgtgc caccacgccc agctaattct tgtat        2815


<210>  1956
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  1956

Met Leu Trp Glu Arg His Arg Glu Leu Ser Gly Gly Ala Glu Ala Gly 
1               5                   10                  15      


Thr Val Pro Thr Ser Pro Gly Lys Val Pro Glu Asp Ser Leu Ala Arg 
            20                  25                  30          


Leu Leu Arg Val Leu Gln Asp Leu Arg Glu Ala His Ser Ser Ser Pro 
        35                  40                  45              


Ala Gly Ser Pro Pro Ser Glu Pro Asn Cys Leu Leu Glu Leu Gln Thr 
    50                  55                  60                  


<210>  1957
<211>  1314
<212>  DNA
<213>  Homosapiens

<400>  1957
ccgcgtgccc cgccgtggtg cgcgccacct tccgccagct cttccggcgc gtgcgcgagc     60

gcttccccgg cgcccagcac gaggtgcgcc ctccacccgc tgggctaggc tgggccgggt    120

tggactgggc tggggcgagg ggcgggcgaa gagcggtggg gaaccaggga gcgctgggga    180

ggaccaggga ggctgtgtcc cggcgagggt cagggacgga gcctaagggg agggggctgc    240

caggagccct ggtctggggg actccagccc gcgctcttcc gcacccctcc agaatgtacc    300

gttcatcgcc gtcaccagct tcctgtgcct gcgcttcttc tctcccgcca tcatgtcgcc    360

caagctcttc cacctgcggg agcgccacgc ggacgcccgc accagccgca ccctgctcct    420

gttggccaag gtgcgggcct tgcggccacg ggcgggatgc acagctgggt gtcctaccgg    480

ggccctggcc tggactgcag agtgttccct accggctccg gcgaggccac tggcacgccc    540

acgtaggcac tgcacttcac agtttgcaaa gccttcctgt ggccaccttg tccgagttcc    600

atctcatgga taagggaaca ggcctgcgag gggtcggggg ttgccaaggc cgcccatcct    660

gtcggtggtg aatcgcggga ccttccaacc caggcagtcc agaacgtggg caacatggac    720

acgccggctt ccagggccaa ggaggcttgg atggagccgc tgcagcccac cgtgcgccag    780

ggcgtggcgc agctgaagga cttcatcacc aagctcgtgg acatcgagga gaaggacggt    840

gagcgccgcc ctgcacagac ccgcccacag cctactgctg acgtttgctc cgcccttgag    900

ccccacggcc ccacccaccg ctgtttgttc ctctcgtggc cccacccacc gcctgctgtt    960

gacatttgcc aggcccccag gccatagacc cacgcaccac tgtttgtgct tcctgtgacc   1020

ctgcccactg cctgctgttg acgtttgccc cacccctaga cccatggcct cacctcccat   1080

catctgtgcc tgttgacatt tgctccatcc ttgagctcca tagccccgcc gccacctgct   1140

actgacgcgt gtcccgcctc caagcccatg gccctgcctt cctcagtcca cctgtcaccc   1200

cgctcaccac cagctgttga tgtttgctcc gcccttgagc cccatgacta cgtccactgc   1260

ctgctgttca gatttgctca gcccttgagc cccatggccc cgcccactgc tccg         1314


<210>  1958
<211>  90
<212>  PRT
<213>  Homosapiens

<400>  1958

Met Asp Thr Pro Ala Ser Arg Ala Lys Glu Ala Trp Met Glu Pro Leu 
1               5                   10                  15      


Gln Pro Thr Val Arg Gln Gly Val Ala Gln Leu Lys Asp Phe Ile Thr 
            20                  25                  30          


Lys Leu Val Asp Ile Glu Glu Lys Asp Gly Glu Arg Arg Pro Ala Gln 
        35                  40                  45              


Thr Arg Pro Gln Pro Thr Ala Asp Val Cys Ser Ala Leu Glu Pro His 
    50                  55                  60                  


Gly Pro Thr His Arg Cys Leu Phe Leu Ser Trp Pro His Pro Pro Pro 
65                  70                  75                  80  


Ala Val Asp Ile Cys Gln Ala Pro Arg Pro 
                85                  90  


<210>  1959
<211>  1222
<212>  DNA
<213>  Homosapiens

<400>  1959
gcgagcgctt ccccggcgcc cagcacgagg tgcgccctcc acccgctggg ctaggctggg     60

ccgggttgga ctgggctggg gcgaggggcg ggcgaagagc ggtggggaac cagggagcgc    120

tggggaggac cagggaggct gtgtcccggc gagggtcagg gacggagcct aaggggaggg    180

ggctgccagg agccctggtc tgggggactc cagcccgcgc tcttccgcac ccctccagaa    240

tgtaccgttc atcgccgtca ccagcttcct gtgcctgcgc ttcttctctc ccgccatcat    300

gtcgcccaag ctcttccacc tgcgggagcg ccacgcggac gcccgcacca gccgcaccct    360

gctcctgttg gccaaggcag tccagaacgt gggcaacatg gacacgccgg cttccagggc    420

caaggaggct tggatggagc cgctgcagcc caccgtgcgc cagggcgtgg cgcagctgaa    480

ggacttcatc accaagctcg tggacatcga ggagaaggac gagctggacc tgcagcggac    540

gctgagtttg caggcgccac ctgtgaagga ggggccactc ttcatccaca ggaccaaggg    600

caagggcccc ctcatgtcct cctccttcaa gaagctctac ttctccctca ctaccgaggc    660

cctcagcttc gcgaagacgc ccagctccaa gaaaagcgcc ctcatcaagt tagccaacat    720

ccgggcagca gaaaaggttg aggaaaagaa ctttggcagc tcgcacgtca tgcaggtcat    780

ctacacggac gacgccggca ggccccagac tgcctacctg cagtgcaagt gtgtgaatga    840

gcttaaccag tggctgtctg tgctgcggaa ggtcagggct gcgataagac ccggtcacgg    900

gtgaccctgc aggagtggaa tgaccctctt gaccatgacc ttgaggccca gctcatctac    960

cggcacctgc tgggcgtgga ggccatgctg tggtgagtcc cacccaggag agcctgtgca   1020

gcctggggaa cgtgccaggc ttggggctgc tccatggtgg ctggtcacct ctcttgtaat   1080

tggccacatc tggggagggc accaggagta cctctctgca gcacgaggcc agctcaggtt   1140

aggacagagg ccccaagggt cagggccatg cctgcttcat gccatgtgct gactgagccc   1200

accttgcaac ctgcccagct gt                                            1222


<210>  1960
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  1960

Met Ser Pro Lys Leu Phe His Leu Arg Glu Arg His Ala Asp Ala Arg 
1               5                   10                  15      


Thr Ser Arg Thr Leu Leu Leu Leu Ala Lys Ala Val Gln Asn Val Gly 
            20                  25                  30          


Asn Met Asp Thr Pro Ala Ser Arg Ala Lys Glu Ala Trp Met Glu Pro 
        35                  40                  45              


Leu Gln Pro Thr Val Arg Gln Gly Val Ala Gln Leu Lys Asp Phe Ile 
    50                  55                  60                  


Thr Lys Leu Val Asp Ile Glu Glu Lys Asp Glu Leu Asp Leu Gln Arg 
65                  70                  75                  80  


Thr Leu Ser Leu Gln Ala Pro Pro Val Lys Glu Gly Pro Leu Phe Ile 
                85                  90                  95      


His Arg Thr Lys Gly Lys Gly Pro Leu Met Ser Ser Ser Phe Lys Lys 
            100                 105                 110         


Leu Tyr Phe Ser Leu Thr Thr Glu Ala Leu Ser Phe Ala Lys Thr Pro 
        115                 120                 125             


Ser Ser Lys Lys Ser Ala Leu Ile Lys Leu Ala Asn Ile Arg Ala Ala 
    130                 135                 140                 


Glu Lys Val Glu Glu Lys Asn Phe Gly Ser Ser His Val Met Gln Val 
145                 150                 155                 160 


Ile Tyr Thr Asp Asp Ala Gly Arg Pro Gln Thr Ala Tyr Leu Gln Cys 
                165                 170                 175     


Lys Cys Val Asn Glu Leu Asn Gln Trp Leu Ser Val Leu Arg Lys Val 
            180                 185                 190         


Arg Ala Ala Ile Arg Pro Gly His Gly 
        195                 200     


<210>  1961
<211>  4441
<212>  DNA
<213>  Homosapiens

<400>  1961
attcccctcc ctccctggcc tggcagagct ggacctgcag cggacgctga gtttgcaggc     60

gccacctgtg aaggaggggc cactcttcat ccacaggacc aagggcaagg gccccctcat    120

gtcctcctcc ttcaagaagc tctacttctc cctcactacc gaggccctca gcttcgcgaa    180

gacgcccagc tccaagtgtg tgaatgagct taaccagtgg ctgtctgtgc tgcggaaggt    240

gagcatcaac aacaccggac tgctgggctc ctaccaccct ggcatcttct gtggggacaa    300

gtggagctgc tgccaccaaa aagagaagac aggtgggaga ggaggcctgg gtcccgggct    360

ctgcatccgt ccactgcgag atcgggcctc tggctgaacg atgggaccgt gagccctgct    420

gtgcacctgc agggacataa cccaaggaat gctggcccct ccaggagctc tgggcagaaa    480

gggtcccgtg gaccaggtca gggctgcgat aagacccggt cacgggtgac cctgcaggag    540

tggaatgacc ctcttgacca tgaccttgag gcccagctca tctaccggca cctgctgggc    600

gtggaggcca tgctgtggga gaggcaccgg gagctgagcg ggggtgcaga ggcaggcacg    660

gtgcccacga gccctggcaa agtccccgag gactcattgg cccggctgct ccgggtgctg    720

caggacctcc gcgaggccca tagctccagc ccggccggct ccccaccctc agagcccaac    780

tgcctcctgg agctgcagac gtgaggcccg ccctacgctc ccttgctgag tcccctgcca    840

agcgctcgga gcccctccag gacactctgc accccctcac cccggtcctc ctcattaggg    900

tgcagggcct aggtctcttc caagtggggg aggggggaga gtcaggaata aggggatccc    960

cagaagtgca gagctgagca ggcttgggcc tgtcatggct ggcctgaagt gtccccagct   1020

ccctacagcc gctgtagcca tcactgcctc tccagggacc ctcctctcct gcctaggaca   1080

gacccagcca gaaccactgc taggatgggc cacacccagg ggtctggcct ccagggacct   1140

agagaatggg agggagaacg gggccccagg agacccggcc gccaccccac ccgctaccct   1200

tgggtgccac agggctgtgc tgttgccaac agtaaacctg ctgttactgt ccaggctctg   1260

gggtcttgtg atgagggtct ggggagaaag tgggcccggg gggaccccgg aggctgtcgg   1320

tggatgtgcc gatgatgggg ctgacagtat gggctctggg catccctgtt cccccctctt   1380

tcttcccccc actcttctgg ggtcgggggt tcctttccct tcccagttgc tgtccctggg   1440

tcccctcttt catgtcccac aggccacaga gcccagtgtg tccaaccagc tgttctctcc   1500

tcaaagcagc ccccaagcaa gtcccttctc tagggtgtcc ctgaggacag cacagatgcg   1560

ggactcagag accccattcc tcttcacgca gcccttaccc caagccctct agctgtgtgg   1620

ctggcagtgt tggccacgta ggggctccca tccccccacc attgtgtcac ataggctgcc   1680

aggctcagct cccagctgcg tccacagtga cctggatcag ggtggggaca aggactggac   1740

cctccttctc cagaaggcct tcagctcttg ccttgccatg cagtcacctc cttccccctc   1800

tgaccccaga tcccaaaggt gcaccgttgc cccagcccct ttctggcccc atggggtttc   1860

tctgatgcct tcatcataga ggcccggggc tggtccgatg gttggcaaaa cttgactccg   1920

gcccagtccc cactcttggg gacttagaac ccctggtgtc ctgggatctg gcctgccttt   1980

ctttggtcag tccctgtggt cccccaccag ctccccctcc catagggctg cccaccaagc   2040

cctgccccca gcccaagagg agcccccact gcctgcgggg cagtgatgtc tggccaccgg   2100

ctcacaccaa tgacttggtc ctggggtggc agaagcagca ggtgacagga gcagggcccc   2160

tgtccctctc ttctggccct gtggtaccca ggccacacgt tgtgcccgct cttagggctg   2220

accggctgca gggaccacca gccgctgcta ctgtgggccg ccccggggca gggtgggcag   2280

ggcttttgtg ggttatgagg acacagaagt ccctgaggcc cccagacctg gcacagccaa   2340

cctccttcct cccccggttg cccccaactc taaagcctcc tccctcccag tgtccactgg   2400

ctccaggctc ctcacaacag cagctcatag acacagggcg tctccaggtg tcccagccct   2460

ccagatgttt ctagctctcc agatgggcgc tgttttcacg tctgcctgca tccattcatt   2520

ccttcattcc tcacctttat cctgttatct ctattttttt aagctaccag gaaggaaagg   2580

gaagaagaga tcacgaaact gggaccccca gaagggagga gtgggctttg aacttagaca   2640

tctacctcag agctcaaata ggttgtttaa aatcacattc aattttcaga tgaaggggaa   2700

ctttatagtt ttttttgttt gtttgttttt ttgagacaga gtctcactct gttgcccagg   2760

ctggagtgca aatggcttga tcttggttca ctgcaacctc tgcctcccag gttcaagcaa   2820

ttctcttgcc tcagcctccc gagtagctgg gactacaggc gtgtgccacc acgcccagct   2880

aattcttgta tttttagtag agacggagtt tctccatgtt ggccagactg gtctcgaact   2940

cctgacctca ggtgatctga ccgccttggc ttccgaaagt gctgagatta cagttgcgag   3000

ccactgtgca tggccagaac tttataataa ttaaaagaga cttgaagctg ggtgtgacgg   3060

tgcacacctc tagtcccagc tactcgggag gccaaggcag aaggatcacc ttgaggccag   3120

gagtttaagg ccagcctggg caacatagca aaacctagtc cctaaaatta aaaaaaaaaa   3180

aaaaaaaagg aaaataaagg agacttgaaa tttttgaact aaatagtggt gatggctata   3240

cattgtgaat gtaattaaca ccactgagtt aaacacttaa aatggttaaa atggcaaatt   3300

gtatgttata cctattttac tacaataaaa agtataaaaa agaggcaaga tatttaggtg   3360

acttacagca accaattgca acaaaacaaa atgttaagaa atgatctttt tatgaggcaa   3420

ttggaaattt gaacactgat caactatagg atgattggaa ttattaattt tgtaaaggtg   3480

tgataagata ctgcacttgg ctgggcacag tggcacatgc ctgtaatccc agctacttgg   3540

caggctgagg tgggagaatc gcttgagctc aggagttcga gaccagcctg ggcaatgtgg   3600

cgaaatcccc gtctttacaa aaacaaacaa acaaacaaaa aagatattgc agttgtgttg   3660

taagcgtcct tatctttcag agctacatag tggaatgttt atggaatatt taggataaat   3720

gatatacgca tttgggattt gctgcaaaat gacccagagt caggggtcag ggggagaggt   3780

agagatgaga caagaggtag aggggagagg tagaggtagc cacgagctga taattacaga   3840

caagagatgc ggagtatgtg ggggctcatt atcctgcata gtctatcttt gtatatcttt   3900

gaacttttca agaataaaaa agcttaaaaa gtatacatgg cctggtccta ccagagactc   3960

acccaatgcc agcctccagc cagggagagc caagtttgca ttttcacacg catctcacac   4020

tcctctgcac tctcaacttg gagagctcca aacagggaaa ccccaagcct tgctggcttc   4080

tgccaacccc ctgaacagaa gcatgggtcc ccctgatcac cacctcacca ccctcatcct   4140

gatctcactg gagactccct ttcccggtct gctaagtagc gggtgttttt ccttgacact   4200

aacgctaccg ctagaccacg gtcggcttgg caacaggtgt cttcccagat gctggcgtta   4260

ctgctagacc aaggagccct ctggtggccc tgtccgggca taacagaaag ctcgcactct   4320

ttgtcttctg gtcactcctc actgtcccct cagctcccat ctctgtatgg cctggttttt   4380

cctaggttat gattgtagag cgaggattat tataatattg gaataaagaa taattactac   4440

a                                                                   4441


<210>  1962
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  1962

Met Leu Trp Glu Arg His Arg Glu Leu Ser Gly Gly Ala Glu Ala Gly 
1               5                   10                  15      


Thr Val Pro Thr Ser Pro Gly Lys Val Pro Glu Asp Ser Leu Ala Arg 
            20                  25                  30          


Leu Leu Arg Val Leu Gln Asp Leu Arg Glu Ala His Ser Ser Ser Pro 
        35                  40                  45              


Ala Gly Ser Pro Pro Ser Glu Pro Asn Cys Leu Leu Glu Leu Gln Thr 
    50                  55                  60                  


<210>  1963
<211>  4051
<212>  DNA
<213>  Homosapiens

<400>  1963
ctgggctagg ctgggccggg ttggactggg ctggggcgag gggcgggcga agagcggtgg     60

ggaaccaggg agcgctgggg aggaccaggg aggctgtgtc ccggcgaggg tcagggacgg    120

agcctaaggg gagggggctg ccaggagccc tggtctgggg gactccagcc cgcgctcttc    180

cgcacccctc cagaatgtac cgttcatcgc cgtcaccagc ttcctgtgcc tgcgcttctt    240

ctctcccgcc atcatgtcgc ccaagctctt ccacctgcgg gagcgccacg cggacgcccg    300

caccagccgc accctgctcc tgttggccaa ggcagtccag aacgtgggca acatggacac    360

gccggcttcc agggccaagg aggcttggat ggagccgctg cagcccaccg tgcgccaggg    420

cgtggcgcag ctgaaggact tcatcaccaa gctcgtggac atcgaggaga aggacgagct    480

ggacctgcag cggacgctga gtttgcaggc gccacctgtg aaggaggggc cactcttcat    540

ccacaggacc aagggcaagg gccccctcat gtcctcctcc ttcaagaagc tctacttctc    600

cctcactacc gaggccctca gcttcgcgaa gacgcccagc tccaaggagt tcccttttgt    660

gtcagggtcc agagccactg ggaaaagtag tgatatcagg gccaccaaat atatttggcg    720

ggttctggaa tacctacgag cgtggccaag gggccagcgg cggctgaaat ccagcccaca    780

ccagcctcct gggctcctac catcccggtg ccttccgtgg ggacaagtgg agctgttgcc    840

accaaaaaga caagacagtg tgtgaatgag cttaaccagt ggctgtctgt gctgcggaag    900

gtgagcatca acaacaccgg actgctgggc tcctaccacc ctggcatctt ctgtggggac    960

aagtggagct gctgccacca aaaagagaag acaggtggga gaggaggcct gggtcccggg   1020

ctctgcatcc gtccactgcg agatcgggcc tctggctgaa cgatgggacc gtgagccctg   1080

ctgtgcacct gcagggacat aacccaagga atgctggccc ctccaggagc tctgggcaga   1140

aagggtcccg tggaccaggt ggtttgggaa atgccacgtg atgtgtgtga agcacatgag   1200

tgaattcgct gaaggctcta aggaggcccg aaaacacgtt agaatcccat ttctttttat   1260

ttcttcttct tttttttttt tcagacacag attttcactc tgtcccccag actggagtgc   1320

aatggcacga tctcagctca ctgcaatctc cacctcccag ggtcaagcaa ttctcctgcc   1380

tcaacctccc cagtagctgg gattaccggc actcgccacc aagcctagct aatttttttg   1440

tattttgact agagatgggg tttcaccatg ttagtcaagc tgctcttgtt tttttttgtt   1500

gttgttgttg ttgttgtttg ataccaagtc tcgctctatc atccaggctg gagtgcagtg   1560

gtgcaatctc ggctcactgc aatctctgtt tcccaggctc aagtgattct cctgcctcag   1620

cctcccaagt actacaggcg caagccactg cacccagtca gggctgcgat aagacccggt   1680

cacgggtgac cctgcaggag tggaatgacc ctcttgacca tgaccttgag gcccagctca   1740

tctaccggca cctgctgggc gtggaggcca tgctgtggga gaggcaccgg gagctgagcg   1800

ggggtgcaga ggcaggcacg gtgcccacga gccctggcaa agtccccgag gactcattgg   1860

cccggctgct ccgggtgctg caggacctcc gcgaggccca tagctccagc ccggccggct   1920

ccccaccctc agagcccaac tgcctcctgg agctgcagac gtgaggcccg ccctacgctc   1980

ccttgctgag tcccctgcca agcgctcgga gcccctccag gacactctgc accccctcac   2040

cccggtcctc ctcattaggg tgcagggcct aggtctcttc caagtggggg aggggggaga   2100

gtcaggaata aggggatccc cagaagtgca gagctgagca ggcttgggcc tgtcatggct   2160

ggcctgaagt gtccccagct ccctacagcc gctgtagcca tcactgcctc tccagggacc   2220

ctcctctcct gcctaggaca gacccagcca gaaccactgc taggatgggc cacacccagg   2280

ggtctggcct ccagggacct agagaatggg agggagaacg gggccccagg agacccggcc   2340

gccaccccac ccgctaccct tgggtgccac agggctgtgc tgttgccaac agtaaacctg   2400

ctgttactgt ccaggctctg gggtcttgtg atgagggtct ggggagaaag tgggcccggg   2460

gggaccccgg aggctgtcgg tggatgtgcc gatgatgggg ctgacagtat gggctctggg   2520

catccctgtt cccccctctt tcttcccccc actcttctgg ggtcgggggt tcctttccct   2580

tcccagttgc tgtccctggg tcccctcttt catgtcccac aggccacaga gcccagtgtg   2640

tccaaccagc tgttctctcc tcaaagcagc ccccaagcaa gtcccttctc tagggtgtcc   2700

ctgaggacag cacagatgcg ggactcagag accccattcc tcttcacgca gcccttaccc   2760

caagccctct agctgtgtgg ctggcagtgt tggccacgta ggggctccca tccccccacc   2820

attgtgtcac ataggctgcc aggctcagct cccagctgcg tccacagtga cctggatcag   2880

ggtggggaca aggactggac cctccttctc cagaaggcct tcagctcttg ccttgccatg   2940

cagtcacctc cttccccctc tgaccccaga tcccaaaggt gcaccgttgc cccagcccct   3000

ttctggcccc atggggtttc tctgatgcct tcatcataga ggcccggggc tggtccgatg   3060

gttggcaaaa cttgactccg gcccagtccc cactcttggg gacttagaac ccctggtgtc   3120

ctgggatctg gcctgccttt ctttggtcag tccctgtggt cccccaccag ctccccctcc   3180

catagggctg cccaccaagc cctgccccca gcccaagagg agcccccact gcctgcgggg   3240

cagtgatgtc tggccaccgg ctcacaccaa tgacttggtc ctggggtggc agaagcagca   3300

ggtgacagga gcagggcccc tgtccctctc ttctggccct gtggtaccca ggccacacgt   3360

tgtgcccgct cttagggctg accggctgca gggaccacca gccgctgcta ctgtgggccg   3420

ccccggggca gggtgggcag ggcttttgtg ggttatgagg acacagaagt ccctgaggcc   3480

cccagacctg gcacagccaa cctccttcct cccccggttg cccccaactc taaagcctcc   3540

tccctcccag tgtccactgg ctccaggctc ctcacaacag cagctcatag acacagggcg   3600

tctccaggtg tcccagccct ccagatgttt ctagctctcc agatgggcgc tgttttcacg   3660

tctgcctgca tccattcatt ccttcattcc tcacctttat cctgttatct ctattttttt   3720

aagctaccag gaaggaaagg gaagaagaga tcacgaaact gggaccccca gaagggagga   3780

gtgggctttg aacttagaca tctacctcag agctcaaata ggttgtttaa aatcacattc   3840

aattttcaga tgaaggggaa ctttatagtt ttttttgttt gtttgttttt ttgagacaga   3900

gtctcactct gttgcccagg ctggagtgca aatggcttga tcttggttca ctgcaacctc   3960

tgcctcccag gttcaagcaa ttctcttgcc tcagcctccc gagtagctgg gactacaggc   4020

gtgtgccacc acgcccagct aattcttgta t                                  4051


<210>  1964
<211>  203
<212>  PRT
<213>  Homosapiens

<400>  1964

Met Ser Pro Lys Leu Phe His Leu Arg Glu Arg His Ala Asp Ala Arg 
1               5                   10                  15      


Thr Ser Arg Thr Leu Leu Leu Leu Ala Lys Ala Val Gln Asn Val Gly 
            20                  25                  30          


Asn Met Asp Thr Pro Ala Ser Arg Ala Lys Glu Ala Trp Met Glu Pro 
        35                  40                  45              


Leu Gln Pro Thr Val Arg Gln Gly Val Ala Gln Leu Lys Asp Phe Ile 
    50                  55                  60                  


Thr Lys Leu Val Asp Ile Glu Glu Lys Asp Glu Leu Asp Leu Gln Arg 
65                  70                  75                  80  


Thr Leu Ser Leu Gln Ala Pro Pro Val Lys Glu Gly Pro Leu Phe Ile 
                85                  90                  95      


His Arg Thr Lys Gly Lys Gly Pro Leu Met Ser Ser Ser Phe Lys Lys 
            100                 105                 110         


Leu Tyr Phe Ser Leu Thr Thr Glu Ala Leu Ser Phe Ala Lys Thr Pro 
        115                 120                 125             


Ser Ser Lys Glu Phe Pro Phe Val Ser Gly Ser Arg Ala Thr Gly Lys 
    130                 135                 140                 


Ser Ser Asp Ile Arg Ala Thr Lys Tyr Ile Trp Arg Val Leu Glu Tyr 
145                 150                 155                 160 


Leu Arg Ala Trp Pro Arg Gly Gln Arg Arg Leu Lys Ser Ser Pro His 
                165                 170                 175     


Gln Pro Pro Gly Leu Leu Pro Ser Arg Cys Leu Pro Trp Gly Gln Val 
            180                 185                 190         


Glu Leu Leu Pro Pro Lys Arg Gln Asp Ser Val 
        195                 200             


<210>  1965
<211>  3295
<212>  DNA
<213>  Homosapiens

<400>  1965
gcgagcgctt ccccggcgcc cagcacgagg tgcgccctcc acccgctggg ctaggctggg     60

ccgggttgga ctgggctggg gcgaggggcg ggcgaagagc ggtggggaac cagggagcgc    120

tggggaggac cagggaggct gtgtcccggc gagggtcagg gacggagcct aaggggaggg    180

ggctgccagg agccctggtc tgggggactc cagcccgcgc tcttccgcac ccctccagaa    240

tgtaccgttc atcgccgtca ccagcttcct gtgcctgcgc ttcttctctc ccgccatcat    300

gtcgcccaag ctcttccacc tgcgggagcg ccacgcggac gcccgcacca gccgcaccct    360

gctcctgttg gccaaggcag tccagaacgt gggcaacatg gacacgccgg cttccagggc    420

caaggaggct tggatggagc cgctgcagcc caccgtgcgc cagggcgtgg cgcagctgaa    480

ggacttcatc accaagctcg tggacatcga ggagaaggac gagctggacc tgcagcggac    540

gctgagtttg caggcgccac ctgtgaagga ggggccactc ttcatccaca ggaccaaggg    600

caagggcccc ctcatgtcct cctccttcaa gaagctctac ttctccctca ctaccgaggc    660

cctcagcttc gcgaagacgc ccagctccaa gaaaagcgcc ctcatcaagt tagccaacat    720

ccgggcagca gaaaaggttg aggaaaagaa ctttggcagc tcgcacgtca tgcaggtcat    780

ctacacggac gacgccggca ggccccagac tgcctacctg cagtgcaagt gtgtgaatga    840

gcttaaccag tggctgtctg tgctgcggaa ggtgagcatc aacaacaccg gactgctggg    900

ctcctaccac cctggcatct tctgtgggga caagtggagc tgctgccacc aaaaagagaa    960

gacaggtcag ggctgcgata agacccggtc acgggtgacc ctgcaggagt ggaatgaccc   1020

tcttgaccat gaccttgagg cccagctcat ctaccggcac ctgctgggcg tggaggccat   1080

gctgtgtccc cgaggactca ttggcccggc tgctccgggt gctgcaggac ctccgcgagg   1140

cccatagctc cagcccggcc ggctccccac cctcagagcc caactgcctc ctggagctgc   1200

agacgtgagg cccgccctac gctcccttgc tgagtcccct gccaagcgct cggagcccct   1260

ccaggacact ctgcaccccc tcaccccggt cctcctcatt agggtgcagg gcctaggtct   1320

cttccaagtg ggggaggggg gagagtcagg aataagggga tccccagaag tgcagagctg   1380

agcaggcttg ggcctgtcat ggctggcctg aagtgtcccc agctccctac agccgctgta   1440

gccatcactg cctctccagg gaccctcctc tcctgcctag gacagaccca gccagaacca   1500

ctgctaggat gggccacacc caggggtctg gcctccaggg acctagagaa tgggagggag   1560

aacggggccc caggagaccc ggccgccacc ccacccgcta cccttgggtg ccacagggct   1620

gtgctgttgc caacagtaaa cctgctgtta ctgtccaggc tctggggtct tgtgatgagg   1680

gtctggggag aaagtgggcc cggggggacc ccggaggctg tcggtggatg tgccgatgat   1740

ggggctgaca gtatgggctc tgggcatccc tgttcccccc tctttcttcc ccccactctt   1800

ctggggtcgg gggttccttt cccttcccag ttgctgtccc tgggtcccct ctttcatgtc   1860

ccacaggcca cagagcccag tgtgtccaac cagctgttct ctcctcaaag cagcccccaa   1920

gcaagtccct tctctagggt gtccctgagg acagcacaga tgcgggactc agagacccca   1980

ttcctcttca cgcagccctt accccaagcc ctctagctgt gtggctggca gtgttggcca   2040

cgtaggggct cccatccccc caccattgtg tcacataggc tgccaggctc agctcccagc   2100

tgcgtccaca gtgacctgga tcagggtggg gacaaggact ggaccctcct tctccagaag   2160

gccttcagct cttgccttgc catgcagtca cctccttccc cctctgaccc cagatcccaa   2220

aggtgcaccg ttgccccagc ccctttctgg ccccatgggg tttctctgat gccttcatca   2280

tagaggcccg gggctggtcc gatggttggc aaaacttgac tccggcccag tccccactct   2340

tggggactta gaacccctgg tgtcctggga tctggcctgc ctttctttgg tcagtccctg   2400

tggtccccca ccagctcccc ctcccatagg gctgcccacc aagccctgcc cccagcccaa   2460

gaggagcccc cactgcctgc ggggcagtga tgtctggcca ccggctcaca ccaatgactt   2520

ggtcctgggg tggcagaagc agcaggtgac aggagcaggg cccctgtccc tctcttctgg   2580

ccctgtggta cccaggccac acgttgtgcc cgctcttagg gctgaccggc tgcagggacc   2640

accagccgct gctactgtgg gccgccccgg ggcagggtgg gcagggcttt tgtgggttat   2700

gaggacacag aagtccctga ggcccccaga cctggcacag ccaacctcct tcctcccccg   2760

gttgccccca actctaaagc ctcctccctc ccagtgtcca ctggctccag gctcctcaca   2820

acagcagctc atagacacag ggcgtctcca ggtgtcccag ccctccagat gtttctagct   2880

ctccagatgg gcgctgtttt cacgtctgcc tgcatccatt cattccttca ttcctcacct   2940

ttatcctgtt atctctattt ttttaagcta ccaggaagga aagggaagaa gagatcacga   3000

aactgggacc cccagaaggg aggagtgggc tttgaactta gacatctacc tcagagctca   3060

aataggttgt ttaaaatcac attcaatttt cagatgaagg ggaactttat agtttttttt   3120

gtttgtttgt ttttttgaga cagagtctca ctctgttgcc caggctggag tgcaaatggc   3180

ttgatcttgg ttcactgcaa cctctgcctc ccaggttcaa gcaattctct tgcctcagcc   3240

tcccgagtag ctgggactac aggcgtgtgc caccacgccc agctaattct tgtat        3295


<210>  1966
<211>  282
<212>  PRT
<213>  Homosapiens

<400>  1966

Met Ser Pro Lys Leu Phe His Leu Arg Glu Arg His Ala Asp Ala Arg 
1               5                   10                  15      


Thr Ser Arg Thr Leu Leu Leu Leu Ala Lys Ala Val Gln Asn Val Gly 
            20                  25                  30          


Asn Met Asp Thr Pro Ala Ser Arg Ala Lys Glu Ala Trp Met Glu Pro 
        35                  40                  45              


Leu Gln Pro Thr Val Arg Gln Gly Val Ala Gln Leu Lys Asp Phe Ile 
    50                  55                  60                  


Thr Lys Leu Val Asp Ile Glu Glu Lys Asp Glu Leu Asp Leu Gln Arg 
65                  70                  75                  80  


Thr Leu Ser Leu Gln Ala Pro Pro Val Lys Glu Gly Pro Leu Phe Ile 
                85                  90                  95      


His Arg Thr Lys Gly Lys Gly Pro Leu Met Ser Ser Ser Phe Lys Lys 
            100                 105                 110         


Leu Tyr Phe Ser Leu Thr Thr Glu Ala Leu Ser Phe Ala Lys Thr Pro 
        115                 120                 125             


Ser Ser Lys Lys Ser Ala Leu Ile Lys Leu Ala Asn Ile Arg Ala Ala 
    130                 135                 140                 


Glu Lys Val Glu Glu Lys Asn Phe Gly Ser Ser His Val Met Gln Val 
145                 150                 155                 160 


Ile Tyr Thr Asp Asp Ala Gly Arg Pro Gln Thr Ala Tyr Leu Gln Cys 
                165                 170                 175     


Lys Cys Val Asn Glu Leu Asn Gln Trp Leu Ser Val Leu Arg Lys Val 
            180                 185                 190         


Ser Ile Asn Asn Thr Gly Leu Leu Gly Ser Tyr His Pro Gly Ile Phe 
        195                 200                 205             


Cys Gly Asp Lys Trp Ser Cys Cys His Gln Lys Glu Lys Thr Gly Gln 
    210                 215                 220                 


Gly Cys Asp Lys Thr Arg Ser Arg Val Thr Leu Gln Glu Trp Asn Asp 
225                 230                 235                 240 


Pro Leu Asp His Asp Leu Glu Ala Gln Leu Ile Tyr Arg His Leu Leu 
                245                 250                 255     


Gly Val Glu Ala Met Leu Cys Pro Arg Gly Leu Ile Gly Pro Ala Ala 
            260                 265                 270         


Pro Gly Ala Ala Gly Pro Pro Arg Gly Pro 
        275                 280         


<210>  1967
<211>  2697
<212>  DNA
<213>  Homosapiens

<400>  1967
actgcactgc agcctgcgcg acagagcgag actccgtctc aaaaaaaacc aaaagttacc     60

cagcaacccg agtcatatcc tgatgatatc catgctcctc agtcacgcat cccgtggtgc    120

aggggctgac cccaagagga gctgctgccc ccagagggtg gggagccgag gcagggcctg    180

ggtcagactt accaggctat gctcccagcc cagccctcac cagggacccc cgagtgcatc    240

tctctcctct ccaggcctct gtttctccat ctgtgcaacc acagtgttgg acatggtagt    300

cccaagtggc tgcgataaga cccggtcacg ggtgaccctg caggagtgga atgaccctct    360

tgaccatgac cttgaggccc agctcatcta ccggcacctg ctgggcgtgg aggccatgct    420

gtgggagagg caccgggagc tgagcggggg tgcagaggca ggcacggtgc ccacgagccc    480

tggcaaagtc cccgaggact cattggcccg gctgctccgg gtgctgcagg acctccgcga    540

ggcccatagc tccagcccgg ccggctcccc accctcagag cccaactgcc tcctggagct    600

gcagacgtga ggcccgccct acgctccctt gctgagtccc ctgccaagcg ctcggagccc    660

ctccaggaca ctctgcaccc cctcaccccg gtcctcctca ttagggtgca gggcctaggt    720

ctcttccaag tgggggaggg gggagagtca ggaataaggg gatccccaga agtgcagagc    780

tgagcaggct tgggcctgtc atggctggcc tgaagtgtcc ccagctccct acagccgctg    840

tagccatcac tgcctctcca gggaccctcc tctcctgcct aggacagacc cagccagaac    900

cactgctagg atgggccaca cccaggggtc tggcctccag ggacctagag aatgggaggg    960

agaacggggc cccaggagac ccggccgcca ccccacccgc tacccttggg tgccacaggg   1020

ctgtgctgtt gccaacagta aacctgctgt tactgtccag gctctggggt cttgtgatga   1080

gggtctgggg agaaagtggg cccgggggga ccccggaggc tgtcggtgga tgtgccgatg   1140

atggggctga cagtatgggc tctgggcatc cctgttcccc cctctttctt ccccccactc   1200

ttctggggtc gggggttcct ttcccttccc agttgctgtc cctgggtccc ctctttcatg   1260

tcccacaggc cacagagccc agtgtgtcca accagctgtt ctctcctcaa agcagccccc   1320

aagcaagtcc cttctctagg gtgtccctga ggacagcaca gatgcgggac tcagagaccc   1380

cattcctctt cacgcagccc ttaccccaag ccctctagct gtgtggctgg cagtgttggc   1440

cacgtagggg ctcccatccc cccaccattg tgtcacatag gctgccaggc tcagctccca   1500

gctgcgtcca cagtgacctg gatcagggtg gggacaagga ctggaccctc cttctccaga   1560

aggccttcag ctcttgcctt gccatgcagt cacctccttc cccctctgac cccagatccc   1620

aaaggtgcac cgttgcccca gcccctttct ggccccatgg ggtttctctg atgccttcat   1680

catagaggcc cggggctggt ccgatggttg gcaaaacttg actccggccc agtccccact   1740

cttggggact tagaacccct ggtgtcctgg gatctggcct gcctttcttt ggtcagtccc   1800

tgtggtcccc caccagctcc ccctcccata gggctgccca ccaagccctg cccccagccc   1860

aagaggagcc cccactgcct gcggggcagt gatgtctggc caccggctca caccaatgac   1920

ttggtcctgg ggtggcagaa gcagcaggtg acaggagcag ggcccctgtc cctctcttct   1980

ggccctgtgg tacccaggcc acacgttgtg cccgctctta gggctgaccg gctgcaggga   2040

ccaccagccg ctgctactgt gggccgcccc ggggcagggt gggcagggct tttgtgggtt   2100

atgaggacac agaagtccct gaggccccca gacctggcac agccaacctc cttcctcccc   2160

cggttgcccc caactctaaa gcctcctccc tcccagtgtc cactggctcc aggctcctca   2220

caacagcagc tcatagacac agggcgtctc caggtgtccc agccctccag atgtttctag   2280

ctctccagat gggcgctgtt ttcacgtctg cctgcatcca ttcattcctt cattcctcac   2340

ctttatcctg ttatctctat ttttttaagc taccaggaag gaaagggaag aagagatcac   2400

gaaactggga cccccagaag ggaggagtgg gctttgaact tagacatcta cctcagagct   2460

caaataggtt gtttaaaatc acattcaatt ttcagatgaa ggggaacttt atagtttttt   2520

ttgtttgttt gtttttttga gacagagtct cactctgttg cccaggctgg agtgcaaatg   2580

gcttgatctt ggttcactgc aacctctgcc tcccaggttc aagcaattct cttgcctcag   2640

cctcccgagt agctgggact acaggcgtgt gccaccacgc ccagctaatt cttgtat      2697


<210>  1968
<211>  105
<212>  PRT
<213>  Homosapiens

<400>  1968

Met Val Val Pro Ser Gly Cys Asp Lys Thr Arg Ser Arg Val Thr Leu 
1               5                   10                  15      


Gln Glu Trp Asn Asp Pro Leu Asp His Asp Leu Glu Ala Gln Leu Ile 
            20                  25                  30          


Tyr Arg His Leu Leu Gly Val Glu Ala Met Leu Trp Glu Arg His Arg 
        35                  40                  45              


Glu Leu Ser Gly Gly Ala Glu Ala Gly Thr Val Pro Thr Ser Pro Gly 
    50                  55                  60                  


Lys Val Pro Glu Asp Ser Leu Ala Arg Leu Leu Arg Val Leu Gln Asp 
65                  70                  75                  80  


Leu Arg Glu Ala His Ser Ser Ser Pro Ala Gly Ser Pro Pro Ser Glu 
                85                  90                  95      


Pro Asn Cys Leu Leu Glu Leu Gln Thr 
            100                 105 


<210>  1969
<211>  2886
<212>  DNA
<213>  Homosapiens

<400>  1969
taacacagtg aaaccccgtc tctactaaaa atataaaaaa ttagctgggc gtggtggcgg     60

gcatctgcag tcccagctac tcaggagtct gaaacaggag aatggcgtga acctgggagg    120

cagagctcgc agtgagccaa gatcgtgcca ctgcactgca gcctgcgcga cagagcgaga    180

ctccgtctca aaaaaaacca aaagttaccc agcaacccga gtcatatcct gatgatatcc    240

atgctcctca gtcacgcatc ccgtggtgca ggggctgacc ccaagaggag ctgctgcccc    300

cagagggtgg ggagccgagg cagggcctgg gtcagactta ccaggctatg ctcccagccc    360

agccctcacc agggaccccc gagtgcatct ctctcctctc caggcctctg tttctccatc    420

tgtgcaacca cagtgttgga catggtagtc ccaagtgtct gcttgtaact ttgccctctc    480

tgtgccccca ggtcagggct gcgataagac ccggtcacgg gtgaccctgc aggagtggaa    540

tgaccctctt gaccatgacc ttgaggccca gctcatctac cggcacctgc tgggcgtgga    600

ggccatgctg tgggagaggc accgggagct gagcgggggt gcagaggcag gcacggtgcc    660

cacgagccct ggcaaagtcc ccgaggactc attggcccgg ctgctccggg tgctgcagga    720

cctccgcgag gcccatagct ccagcccggc cggctcccca ccctcagagc ccaactgcct    780

cctggagctg cagacgtgag gcccgcccta cgctcccttg ctgagtcccc tgccaagcgc    840

tcggagcccc tccaggacac tctgcacccc ctcaccccgg tcctcctcat tagggtgcag    900

ggcctaggtc tcttccaagt gggggagggg ggagagtcag gaataagggg atccccagaa    960

gtgcagagct gagcaggctt gggcctgtca tggctggcct gaagtgtccc cagctcccta   1020

cagccgctgt agccatcact gcctctccag ggaccctcct ctcctgccta ggacagaccc   1080

agccagaacc actgctagga tgggccacac ccaggggtct ggcctccagg gacctagaga   1140

atgggaggga gaacggggcc ccaggagacc cggccgccac cccacccgct acccttgggt   1200

gccacagggc tgtgctgttg ccaacagtaa acctgctgtt actgtccagg ctctggggtc   1260

ttgtgatgag ggtctgggga gaaagtgggc ccggggggac cccggaggct gtcggtggat   1320

gtgccgatga tggggctgac agtatgggct ctgggcatcc ctgttccccc ctctttcttc   1380

cccccactct tctggggtcg ggggttcctt tcccttccca gttgctgtcc ctgggtcccc   1440

tctttcatgt cccacaggcc acagagccca gtgtgtccaa ccagctgttc tctcctcaaa   1500

gcagccccca agcaagtccc ttctctaggg tgtccctgag gacagcacag atgcgggact   1560

cagagacccc attcctcttc acgcagccct taccccaagc cctctagctg tgtggctggc   1620

agtgttggcc acgtaggggc tcccatcccc ccaccattgt gtcacatagg ctgccaggct   1680

cagctcccag ctgcgtccac agtgacctgg atcagggtgg ggacaaggac tggaccctcc   1740

ttctccagaa ggccttcagc tcttgccttg ccatgcagtc acctccttcc ccctctgacc   1800

ccagatccca aaggtgcacc gttgccccag cccctttctg gccccatggg gtttctctga   1860

tgccttcatc atagaggccc ggggctggtc cgatggttgg caaaacttga ctccggccca   1920

gtccccactc ttggggactt agaacccctg gtgtcctggg atctggcctg cctttctttg   1980

gtcagtccct gtggtccccc accagctccc cctcccatag ggctgcccac caagccctgc   2040

ccccagccca agaggagccc ccactgcctg cggggcagtg atgtctggcc accggctcac   2100

accaatgact tggtcctggg gtggcagaag cagcaggtga caggagcagg gcccctgtcc   2160

ctctcttctg gccctgtggt acccaggcca cacgttgtgc ccgctcttag ggctgaccgg   2220

ctgcagggac caccagccgc tgctactgtg ggccgccccg gggcagggtg ggcagggctt   2280

ttgtgggtta tgaggacaca gaagtccctg aggcccccag acctggcaca gccaacctcc   2340

ttcctccccc ggttgccccc aactctaaag cctcctccct cccagtgtcc actggctcca   2400

ggctcctcac aacagcagct catagacaca gggcgtctcc aggtgtccca gccctccaga   2460

tgtttctagc tctccagatg ggcgctgttt tcacgtctgc ctgcatccat tcattccttc   2520

attcctcacc tttatcctgt tatctctatt tttttaagct accaggaagg aaagggaaga   2580

agagatcacg aaactgggac ccccagaagg gaggagtggg ctttgaactt agacatctac   2640

ctcagagctc aaataggttg tttaaaatca cattcaattt tcagatgaag gggaacttta   2700

tagttttttt tgtttgtttg tttttttgag acagagtctc actctgttgc ccaggctgga   2760

gtgcaaatgg cttgatcttg gttcactgca acctctgcct cccaggttca agcaattctc   2820

ttgcctcagc ctcccgagta gctgggacta caggcgtgtg ccaccacgcc cagctaattc   2880

ttgtat                                                              2886


<210>  1970
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  1970

Met Leu Trp Glu Arg His Arg Glu Leu Ser Gly Gly Ala Glu Ala Gly 
1               5                   10                  15      


Thr Val Pro Thr Ser Pro Gly Lys Val Pro Glu Asp Ser Leu Ala Arg 
            20                  25                  30          


Leu Leu Arg Val Leu Gln Asp Leu Arg Glu Ala His Ser Ser Ser Pro 
        35                  40                  45              


Ala Gly Ser Pro Pro Ser Glu Pro Asn Cys Leu Leu Glu Leu Gln Thr 
    50                  55                  60                  


<210>  1971
<211>  3677
<212>  DNA
<213>  Homosapiens

<400>  1971
ccgcgtgccc cgccgtggtg cgcgccacct tccgccagct cttccggcgc gtgcgcgagc     60

gcttccccgg cgcccagcac gaggtgcgcc ctccacccgc tgggctaggc tgggccgggt    120

tggactgggc tggggcgagg ggcgggcgaa gagcggtggg gaaccaggga gcgctgggga    180

ggaccaggga ggctgtgtcc cggcgagggt cagggacgga gcctaagggg agggggctgc    240

caggagccct ggtctggggg actccagccc gcgctcttcc gcacccctcc agaatgtacc    300

gttcatcgcc gtcaccagct tcctgtgcct gcgcttcttc tctcccgcca tcatgtcgcc    360

caagctcttc cacctgcggg agcgccacgc ggacgcccgc accagccgca ccctgctcct    420

gttggccaag gtgcgggcct tgcggccacg ggcgggatgc acagctgggt gtcctaccgg    480

ggccctggcc tggactgcag agtgttccct accggctccg gcgaggccac tggcacgccc    540

acgtaggcac tgcacttcac agtttgcaaa gccttcctgt ggccaccttg tccgagttcc    600

atctcatgga taagggaaca ggcctgcgag gggtcggggg ttgccaaggc cgcccatcct    660

gtcggtggtg aatcgcggga ccttccaacc caggcagtcc agaacgtggg caacatggac    720

acgccggctt ccagggccaa ggaggcttgg atggagccgc tgcagcccac cgtgcgccag    780

ggcgtggcgc agctgaagga cttcatcacc aagctcgtgg acatcgagga gaaggacgag    840

ctggacctgc agcggacgct gagtttgcag gcgccacctg tgaaggaggg gccactcttc    900

atccacagga ccaagggcaa gggccccctc atgtcctcct ccttcaagaa gctctacttc    960

tccctcacta ccgaggccct cagcttcgcg aagacgccca gctccaagaa aagcgccctc   1020

atcaagttag ccaacatccg ggcagcagaa aaggttgagg aaaagaactt tggcagctcg   1080

cacgtcatgc aggtcatcta cacggacgac gccggcaggc cccagactgc ctacctgcag   1140

tgcaagtgtg tgaatgagct taaccagtgg ctgtctgtgc tgcggaaggt gagcatcaac   1200

aacaccggac tgctgggctc ctaccaccct ggcatcttct gtggggacaa gtggagctgc   1260

tgccaccaaa aagagaagac aggtcagggc tgcgataaga cccggtcacg ggtgaccctg   1320

caggagtgga atgaccctct tgaccatgac cttgaggccc agctcatcta ccggcacctg   1380

ctgggcgtgg aggccatgct gtgggagagg caccgggagc tgagcggggg tgcagaggca   1440

ggcacggtgc ccacgagccc tggcaaagtc cccgaggact cattggcccg gctgctccgg   1500

gtgctgcagg acctccgcga ggcccatagc tccagcccgg ccggctcccc accctcagag   1560

cccaactgcc tcctggagct gcagacgtga ggcccgccct acgctccctt gctgagtccc   1620

ctgccaagcg ctcggagccc ctccaggaca ctctgcaccc cctcaccccg gtcctcctca   1680

ttagggtgca gggcctaggt ctcttccaag tgggggaggg gggagagtca ggaataaggg   1740

gatccccaga agtgcagagc tgagcaggct tgggcctgtc atggctggcc tgaagtgtcc   1800

ccagctccct acagccgctg tagccatcac tgcctctcca gggaccctcc tctcctgcct   1860

aggacagacc cagccagaac cactgctagg atgggccaca cccaggggtc tggcctccag   1920

ggacctagag aatgggaggg agaacggggc cccaggagac ccggccgcca ccccacccgc   1980

tacccttggg tgccacaggg ctgtgctgtt gccaacagta aacctgctgt tactgtccag   2040

gctctggggt cttgtgatga gggtctgggg agaaagtggg cccgggggga ccccggaggc   2100

tgtcggtgga tgtgccgatg atggggctga cagtatgggc tctgggcatc cctgttcccc   2160

cctctttctt ccccccactc ttctggggtc gggggttcct ttcccttccc agttgctgtc   2220

cctgggtccc ctctttcatg tcccacaggc cacagagccc agtgtgtcca accagctgtt   2280

ctctcctcaa agcagccccc aagcaagtcc cttctctagg gtgtccctga ggacagcaca   2340

gatgcgggac tcagagaccc cattcctctt cacgcagccc ttaccccaag ccctctagct   2400

gtgtggctgg cagtgttggc cacgtagggg ctcccatccc cccaccattg tgtcacatag   2460

gctgccaggc tcagctccca gctgcgtcca cagtgacctg gatcagggtg gggacaagga   2520

ctggaccctc cttctccaga aggccttcag ctcttgcctt gccatgcagt cacctccttc   2580

cccctctgac cccagatccc aaaggtgcac cgttgcccca gcccctttct ggccccatgg   2640

ggtttctctg atgccttcat catagaggcc cggggctggt ccgatggttg gcaaaacttg   2700

actccggccc agtccccact cttggggact tagaacccct ggtgtcctgg gatctggcct   2760

gcctttcttt ggtcagtccc tgtggtcccc caccagctcc ccctcccata gggctgccca   2820

ccaagccctg cccccagccc aagaggagcc cccactgcct gcggggcagt gatgtctggc   2880

caccggctca caccaatgac ttggtcctgg ggtggcagaa gcagcaggtg acaggagcag   2940

ggcccctgtc cctctcttct ggccctgtgg tacccaggcc acacgttgtg cccgctctta   3000

gggctgaccg gctgcaggga ccaccagccg ctgctactgt gggccgcccc ggggcagggt   3060

gggcagggct tttgtgggtt atgaggacac agaagtccct gaggccccca gacctggcac   3120

agccaacctc cttcctcccc cggttgcccc caactctaaa gcctcctccc tcccagtgtc   3180

cactggctcc aggctcctca caacagcagc tcatagacac agggcgtctc caggtgtccc   3240

agccctccag atgtttctag ctctccagat gggcgctgtt ttcacgtctg cctgcatcca   3300

ttcattcctt cattcctcac ctttatcctg ttatctctat ttttttaagc taccaggaag   3360

gaaagggaag aagagatcac gaaactggga cccccagaag ggaggagtgg gctttgaact   3420

tagacatcta cctcagagct caaataggtt gtttaaaatc acattcaatt ttcagatgaa   3480

ggggaacttt atagtttttt ttgtttgttt gtttttttga gacagagtct cactctgttg   3540

cccaggctgg agtgcaaatg gcttgatctt ggttcactgc aacctctgcc tcccaggttc   3600

aagcaattct cttgcctcag cctcccgagt agctgggact acaggcgtgt gccaccacgc   3660

ccagctaatt cttgtat                                                  3677


<210>  1972
<211>  291
<212>  PRT
<213>  Homosapiens

<400>  1972

Met Asp Thr Pro Ala Ser Arg Ala Lys Glu Ala Trp Met Glu Pro Leu 
1               5                   10                  15      


Gln Pro Thr Val Arg Gln Gly Val Ala Gln Leu Lys Asp Phe Ile Thr 
            20                  25                  30          


Lys Leu Val Asp Ile Glu Glu Lys Asp Glu Leu Asp Leu Gln Arg Thr 
        35                  40                  45              


Leu Ser Leu Gln Ala Pro Pro Val Lys Glu Gly Pro Leu Phe Ile His 
    50                  55                  60                  


Arg Thr Lys Gly Lys Gly Pro Leu Met Ser Ser Ser Phe Lys Lys Leu 
65                  70                  75                  80  


Tyr Phe Ser Leu Thr Thr Glu Ala Leu Ser Phe Ala Lys Thr Pro Ser 
                85                  90                  95      


Ser Lys Lys Ser Ala Leu Ile Lys Leu Ala Asn Ile Arg Ala Ala Glu 
            100                 105                 110         


Lys Val Glu Glu Lys Asn Phe Gly Ser Ser His Val Met Gln Val Ile 
        115                 120                 125             


Tyr Thr Asp Asp Ala Gly Arg Pro Gln Thr Ala Tyr Leu Gln Cys Lys 
    130                 135                 140                 


Cys Val Asn Glu Leu Asn Gln Trp Leu Ser Val Leu Arg Lys Val Ser 
145                 150                 155                 160 


Ile Asn Asn Thr Gly Leu Leu Gly Ser Tyr His Pro Gly Ile Phe Cys 
                165                 170                 175     


Gly Asp Lys Trp Ser Cys Cys His Gln Lys Glu Lys Thr Gly Gln Gly 
            180                 185                 190         


Cys Asp Lys Thr Arg Ser Arg Val Thr Leu Gln Glu Trp Asn Asp Pro 
        195                 200                 205             


Leu Asp His Asp Leu Glu Ala Gln Leu Ile Tyr Arg His Leu Leu Gly 
    210                 215                 220                 


Val Glu Ala Met Leu Trp Glu Arg His Arg Glu Leu Ser Gly Gly Ala 
225                 230                 235                 240 


Glu Ala Gly Thr Val Pro Thr Ser Pro Gly Lys Val Pro Glu Asp Ser 
                245                 250                 255     


Leu Ala Arg Leu Leu Arg Val Leu Gln Asp Leu Arg Glu Ala His Ser 
            260                 265                 270         


Ser Ser Pro Ala Gly Ser Pro Pro Ser Glu Pro Asn Cys Leu Leu Glu 
        275                 280                 285             


Leu Gln Thr 
    290     


<210>  1973
<211>  3360
<212>  DNA
<213>  Homosapiens

<400>  1973
gcgagcgctt ccccggcgcc cagcacgagg tgcgccctcc acccgctggg ctaggctggg     60

ccgggttgga ctgggctggg gcgaggggcg ggcgaagagc ggtggggaac cagggagcgc    120

tggggaggac cagggaggct gtgtcccggc gagggtcagg gacggagcct aaggggaggg    180

ggctgccagg agccctggtc tgggggactc cagcccgcgc tcttccgcac ccctccagaa    240

tgtaccgttc atcgccgtca ccagcttcct gtgcctgcgc ttcttctctc ccgccatcat    300

gtcgcccaag ctcttccacc tgcgggagcg ccacgcggac gcccgcacca gccgcaccct    360

gctcctgttg gccaaggcag tccagaacgt gggcaacatg gacacgccgg cttccagggc    420

caaggaggct tggatggagc cgctgcagcc caccgtgcgc cagggcgtgg cgcagctgaa    480

ggacttcatc accaagctcg tggacatcga ggagaaggac gagctggacc tgcagcggac    540

gctgagtttg caggcgccac ctgtgaagga ggggccactc ttcatccaca ggaccaaggg    600

caagggcccc ctcatgtcct cctccttcaa gaagctctac ttctccctca ctaccgaggc    660

cctcagcttc gcgaagacgc ccagctccaa gaaaagcgcc ctcatcaagt tagccaacat    720

ccgggcagca gaaaaggttg aggaaaagaa ctttggcagc tcgcacgtca tgcaggtcat    780

ctacacggac gacgccggca ggccccagac tgcctacctg cagtgcaagt gtgtgaatga    840

gcttaaccag tggctgtctg tgctgcggaa ggtgagcatc aacaacaccg gactgctggg    900

ctcctaccac cctggcatct tctgtgggga caagtggagc tgctgccacc aaaaagagaa    960

gacaggtcag ggctgcgata agacccggtc acgggtgacc ctgcaggagt ggaatgaccc   1020

tcttgaccat gaccttgagg cccagctcat ctaccggcac ctgctgggcg tggaggccat   1080

gctgtgggag aggcaccggg agctgagcgg gggtgcagag gcaggcacgg tgcccacgag   1140

ccctggcaaa gtccccgagg actcattggc ccggctgctc cgggtgctgc aggacctccg   1200

cgaggcccat agctccagcc cggccggctc cccaccctca gagcccaact gcctcctgga   1260

gctgcagacg tgaggcccgc cctacgctcc cttgctgagt cccctgccaa gcgctcggag   1320

cccctccagg acactctgca ccccctcacc ccggtcctcc tcattagggt gcagggccta   1380

ggtctcttcc aagtggggga ggggggagag tcaggaataa ggggatcccc agaagtgcag   1440

agctgagcag gcttgggcct gtcatggctg gcctgaagtg tccccagctc cctacagccg   1500

ctgtagccat cactgcctct ccagggaccc tcctctcctg cctaggacag acccagccag   1560

aaccactgct aggatgggcc acacccaggg gtctggcctc cagggaccta gagaatggga   1620

gggagaacgg ggccccagga gacccggccg ccaccccacc cgctaccctt gggtgccaca   1680

gggctgtgct gttgccaaca gtaaacctgc tgttactgtc caggctctgg ggtcttgtga   1740

tgagggtctg gggagaaagt gggcccgggg ggaccccgga ggctgtcggt ggatgtgccg   1800

atgatggggc tgacagtatg ggctctgggc atccctgttc ccccctcttt cttcccccca   1860

ctcttctggg gtcgggggtt cctttccctt cccagttgct gtccctgggt cccctctttc   1920

atgtcccaca ggccacagag cccagtgtgt ccaaccagct gttctctcct caaagcagcc   1980

cccaagcaag tcccttctct agggtgtccc tgaggacagc acagatgcgg gactcagaga   2040

ccccattcct cttcacgcag cccttacccc aagccctcta gctgtgtggc tggcagtgtt   2100

ggccacgtag gggctcccat ccccccacca ttgtgtcaca taggctgcca ggctcagctc   2160

ccagctgcgt ccacagtgac ctggatcagg gtggggacaa ggactggacc ctccttctcc   2220

agaaggcctt cagctcttgc cttgccatgc agtcacctcc ttccccctct gaccccagat   2280

cccaaaggtg caccgttgcc ccagcccctt tctggcccca tggggtttct ctgatgcctt   2340

catcatagag gcccggggct ggtccgatgg ttggcaaaac ttgactccgg cccagtcccc   2400

actcttgggg acttagaacc cctggtgtcc tgggatctgg cctgcctttc tttggtcagt   2460

ccctgtggtc ccccaccagc tccccctccc atagggctgc ccaccaagcc ctgcccccag   2520

cccaagagga gcccccactg cctgcggggc agtgatgtct ggccaccggc tcacaccaat   2580

gacttggtcc tggggtggca gaagcagcag gtgacaggag cagggcccct gtccctctct   2640

tctggccctg tggtacccag gccacacgtt gtgcccgctc ttagggctga ccggctgcag   2700

ggaccaccag ccgctgctac tgtgggccgc cccggggcag ggtgggcagg gcttttgtgg   2760

gttatgagga cacagaagtc cctgaggccc ccagacctgg cacagccaac ctccttcctc   2820

ccccggttgc ccccaactct aaagcctcct ccctcccagt gtccactggc tccaggctcc   2880

tcacaacagc agctcataga cacagggcgt ctccaggtgt cccagccctc cagatgtttc   2940

tagctctcca gatgggcgct gttttcacgt ctgcctgcat ccattcattc cttcattcct   3000

cacctttatc ctgttatctc tattttttta agctaccagg aaggaaaggg aagaagagat   3060

cacgaaactg ggacccccag aagggaggag tgggctttga acttagacat ctacctcaga   3120

gctcaaatag gttgtttaaa atcacattca attttcagat gaaggggaac tttatagttt   3180

tttttgtttg tttgtttttt tgagacagag tctcactctg ttgcccaggc tggagtgcaa   3240

atggcttgat cttggttcac tgcaacctct gcctcccagg ttcaagcaat tctcttgcct   3300

cagcctcccg agtagctggg actacaggcg tgtgccacca cgcccagcta attcttgtat   3360


<210>  1974
<211>  324
<212>  PRT
<213>  Homosapiens

<400>  1974

Met Ser Pro Lys Leu Phe His Leu Arg Glu Arg His Ala Asp Ala Arg 
1               5                   10                  15      


Thr Ser Arg Thr Leu Leu Leu Leu Ala Lys Ala Val Gln Asn Val Gly 
            20                  25                  30          


Asn Met Asp Thr Pro Ala Ser Arg Ala Lys Glu Ala Trp Met Glu Pro 
        35                  40                  45              


Leu Gln Pro Thr Val Arg Gln Gly Val Ala Gln Leu Lys Asp Phe Ile 
    50                  55                  60                  


Thr Lys Leu Val Asp Ile Glu Glu Lys Asp Glu Leu Asp Leu Gln Arg 
65                  70                  75                  80  


Thr Leu Ser Leu Gln Ala Pro Pro Val Lys Glu Gly Pro Leu Phe Ile 
                85                  90                  95      


His Arg Thr Lys Gly Lys Gly Pro Leu Met Ser Ser Ser Phe Lys Lys 
            100                 105                 110         


Leu Tyr Phe Ser Leu Thr Thr Glu Ala Leu Ser Phe Ala Lys Thr Pro 
        115                 120                 125             


Ser Ser Lys Lys Ser Ala Leu Ile Lys Leu Ala Asn Ile Arg Ala Ala 
    130                 135                 140                 


Glu Lys Val Glu Glu Lys Asn Phe Gly Ser Ser His Val Met Gln Val 
145                 150                 155                 160 


Ile Tyr Thr Asp Asp Ala Gly Arg Pro Gln Thr Ala Tyr Leu Gln Cys 
                165                 170                 175     


Lys Cys Val Asn Glu Leu Asn Gln Trp Leu Ser Val Leu Arg Lys Val 
            180                 185                 190         


Ser Ile Asn Asn Thr Gly Leu Leu Gly Ser Tyr His Pro Gly Ile Phe 
        195                 200                 205             


Cys Gly Asp Lys Trp Ser Cys Cys His Gln Lys Glu Lys Thr Gly Gln 
    210                 215                 220                 


Gly Cys Asp Lys Thr Arg Ser Arg Val Thr Leu Gln Glu Trp Asn Asp 
225                 230                 235                 240 


Pro Leu Asp His Asp Leu Glu Ala Gln Leu Ile Tyr Arg His Leu Leu 
                245                 250                 255     


Gly Val Glu Ala Met Leu Trp Glu Arg His Arg Glu Leu Ser Gly Gly 
            260                 265                 270         


Ala Glu Ala Gly Thr Val Pro Thr Ser Pro Gly Lys Val Pro Glu Asp 
        275                 280                 285             


Ser Leu Ala Arg Leu Leu Arg Val Leu Gln Asp Leu Arg Glu Ala His 
    290                 295                 300                 


Ser Ser Ser Pro Ala Gly Ser Pro Pro Ser Glu Pro Asn Cys Leu Leu 
305                 310                 315                 320 


Glu Leu Gln Thr 
                


<210>  1975
<211>  2144
<212>  DNA
<213>  Homosapiens

<400>  1975
acagcagcgg cgcggagact gcggggcggg ccatggcggc gaacctgagc cggaacgggc     60

cagcgctgca agaggcctac gtgcgggtgg tcaccgagaa gtccccgacc gactgggctc    120

tctttaccta tgaaggcaac agcaatgaca tccgcgtggc tggcacaggg gagggtggcc    180

tggaggagat ggtggaggag ctcaacagcg ggaaggtgat gtacgccttc tgcagagtga    240

aggaccccaa ctctggactg cccaaatttg tcctcatcaa ctggacaggc gagggcgtga    300

acgatgtgcg gaagggagcc tgtgccagcc acgtcagcac catggccagc ttcctgaagg    360

gggcccatgt gaccatcaac gcacgggccg aggaggatgt ggagcctgag tgcatcatgg    420

agaaggtggc caaggcttca ggtgccaact acagctttca caaggagagt ggccgcttcc    480

aggacgtggg accccaggcc ccagtgggct ctgtgtacca gaagaccaat gccgtgtctg    540

agattaaaag ggttggtaaa gacagcttct gggccaaagc agagaaggag gaggagaacc    600

gtcggctgga ggaaaagcgg cgggccgagg aggcacagcg gcagctggag caggagcgcc    660

gggagcgtga gctgcgtgag gctgcacgcc gggagcagcg ctatcaggag cagggtggcg    720

aggccagccc ccagaggacg tgggagcagc agcaagaagt ggtttcaagg aaccgaaatg    780

agcaggagtc tgccgtgcac ccgagggaga ttttcaagca gaaggagagg gccatgtcca    840

ccacctccat ctccagtcct cagcctggca agctgaggag ccccttcctg cagaagcagc    900

tcacccaacc agagacccac tttggcagag agccagctgc tgccatctca aggcccaggg    960

cagatctccc tgctgaggag ccggcgccca gcactcctcc atgtctggtg caggcagaag   1020

aggaggctgt gtatgaggaa cctccagagc aggagacctt ctacgagcag cccccactgg   1080

tgcagcagca aggtgctggc tctgagcaca ttgaccacca cattcagggc caggggctca   1140

gtgggcaagg gctctgtgcc cgtgccctgt acgactacca ggcagccgac gacacagaga   1200

tctcctttga ccccgagaac ctcatcacgg gcatcgaggt gatcgacgaa ggctggtggc   1260

gtggctatgg gccggatggc cattttggca tgttccctgc caactacgtg gagctcattg   1320

agtgaggctg agggcacatc ttgcccttcc cctctcagac atggcttcct tattgctgga   1380

agaggaggcc tgggagttga cattcagcac tcttccagga ataggacccc cagtgaggat   1440

gaggcctcag ggctccctcc ggcttggcag actcagcctg tcaccccaaa tgcagcaatg   1500

gcctggtgat tcccacacat ccttcctgca tcccccgacc ctcccagaca gcttggctct   1560

tgcccctgac aggatactga gccaagccct gcctgtggcc aagccctgag tggccactgc   1620

caagctgcgg ggaagggtcc tgagcagggg catctgggag gctctggctg ccttctgcat   1680

ttatttgcct tttttctttt tctcttgctt ctaaggggtg gtggccacca ctgtttagaa   1740

tgacccttgg gaacagtgaa cgtagagaat tgtttttagc agagtttgtg accaaagtca   1800

gagtggatca tggtggtttg gcagcaggga atttgtcttg ttggagcctg ctctgtgctc   1860

cccactccat ttctctgtcc ctctgcctgg gctatgggaa gtggggatgc agatggccaa   1920

gctcccaccc tgggtattca aaaacggcag acacaacatg ttcctccacg cggctcactc   1980

gatgcctgca ggccccagtg tgtgcctcaa ctgattctga cttcaggaaa agtaacacag   2040

agtggccttg gcctgttgtc ttcccctatt ttctgtccca gctcatccgt gtctctgaag   2100

aacaaatatg cttttggacc acgaaaaaaa aaaaaaaaaa aaaa                    2144


<210>  1976
<211>  430
<212>  PRT
<213>  Homosapiens

<400>  1976

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Arg Thr Trp Glu Gln Gln 
225                 230                 235                 240 


Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val His 
                245                 250                 255     


Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr Thr Ser 
            260                 265                 270         


Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln Lys 
        275                 280                 285             


Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala Ala Ala 
    290                 295                 300                 


Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser 
305                 310                 315                 320 


Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu 
                325                 330                 335     


Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln 
            340                 345                 350         


Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly 
        355                 360                 365             


Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala 
    370                 375                 380                 


Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr Gly 
385                 390                 395                 400 


Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly 
                405                 410                 415     


His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
            420                 425                 430 


<210>  1977
<211>  2147
<212>  DNA
<213>  Homosapiens

<400>  1977
acagcagcgg cgcggagact gcggggcggg ccatggcggc gaacctgagc cggaacgggc     60

cagcgctgca agaggcctac gtgcgggtgg tcaccgagaa gtccccgacc gactgggctc    120

tctttaccta tgaaggcaac agcaatgaca tccgcgtggc tggcacaggg gagggtggcc    180

tggaggagat ggtggaggag ctcaacagcg ggaaggtgat gtacgccttc tgcagagtga    240

aggaccccaa ctctggactg cccaaatttg tcctcatcaa ctggacaggc gagggcgtga    300

acgatgtgcg gaagggagcc tgtgccagcc acgtcagcac catggccagc ttcctgaagg    360

gggcccatgt gaccatcaac gcacgggccg aggaggatgt ggagcctgag tgcatcatgg    420

agaaggtggc caaggcttca ggtgccaact acagctttca caaggagagt ggccgcttcc    480

aggacgtggg accccaggcc ccagtgggct ctgtgtacca gaagaccaat gccgtgtctg    540

agattaaaag ggttggtaaa gacagcttct gggccaaagc agagaaggag gaggagaacc    600

gtcggctgga ggaaaagcgg cgggccgagg aggcacagcg gcagctggag caggagcgcc    660

gggagcgtga gctgcgtgag gctgcacgcc gggagcagcg ctatcaggag cagggtggcg    720

aggccagccc ccagagcagg acgtgggagc agcagcaaga agtggtttca aggaaccgaa    780

atgagcagga gtctgccgtg cacccgaggg agattttcaa gcagaaggag agggccatgt    840

ccaccacctc catctccagt cctcagcctg gcaagctgag gagccccttc ctgcagaagc    900

agctcaccca accagagacc cactttggca gagagccagc tgctgccatc tcaaggccca    960

gggcagatct ccctgctgag gagccggcgc ccagcactcc tccatgtctg gtgcaggcag   1020

aagaggaggc tgtgtatgag gaacctccag agcaggagac cttctacgag cagcccccac   1080

tggtgcagca gcaaggtgct ggctctgagc acattgacca ccacattcag ggccaggggc   1140

tcagtgggca agggctctgt gcccgtgccc tgtacgacta ccaggcagcc gacgacacag   1200

agatctcctt tgaccccgag aacctcatca cgggcatcga ggtgatcgac gaaggctggt   1260

ggcgtggcta tgggccggat ggccattttg gcatgttccc tgccaactac gtggagctca   1320

ttgagtgagg ctgagggcac atcttgccct tcccctctca gacatggctt ccttattgct   1380

ggaagaggag gcctgggagt tgacattcag cactcttcca ggaataggac ccccagtgag   1440

gatgaggcct cagggctccc tccggcttgg cagactcagc ctgtcacccc aaatgcagca   1500

atggcctggt gattcccaca catccttcct gcatcccccg accctcccag acagcttggc   1560

tcttgcccct gacaggatac tgagccaagc cctgcctgtg gccaagccct gagtggccac   1620

tgccaagctg cggggaaggg tcctgagcag gggcatctgg gaggctctgg ctgccttctg   1680

catttatttg ccttttttct ttttctcttg cttctaaggg gtggtggcca ccactgttta   1740

gaatgaccct tgggaacagt gaacgtagag aattgttttt agcagagttt gtgaccaaag   1800

tcagagtgga tcatggtggt ttggcagcag ggaatttgtc ttgttggagc ctgctctgtg   1860

ctccccactc catttctctg tccctctgcc tgggctatgg gaagtgggga tgcagatggc   1920

caagctccca ccctgggtat tcaaaaacgg cagacacaac atgttcctcc acgcggctca   1980

ctcgatgcct gcaggcccca gtgtgtgcct caactgattc tgacttcagg aaaagtaaca   2040

cagagtggcc ttggcctgtt gtcttcccct attttctgtc ccagctcatc cgtgtctctg   2100

aagaacaaat atgcttttgg accacgaaaa aaaaaaaaaa aaaaaaa                 2147


<210>  1978
<211>  431
<212>  PRT
<213>  Homosapiens

<400>  1978

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Thr Trp Glu Gln 
225                 230                 235                 240 


Gln Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val 
                245                 250                 255     


His Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr Thr 
            260                 265                 270         


Ser Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln 
        275                 280                 285             


Lys Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala Ala 
    290                 295                 300                 


Ala Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro 
305                 310                 315                 320 


Ser Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu 
                325                 330                 335     


Glu Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln 
            340                 345                 350         


Gln Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln 
        355                 360                 365             


Gly Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln 
    370                 375                 380                 


Ala Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr 
385                 390                 395                 400 


Gly Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp 
                405                 410                 415     


Gly His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
            420                 425                 430     


<210>  1979
<211>  845
<212>  DNA
<213>  Homosapiens

<400>  1979
cccgtccaga gtcctctgtg gtccctgctg ccaccatggc cactcaccgc ctcgtgatgg     60

tccggcacgg cgagagcaca tggaaccagg agaaccgttt ctgtggctgg ttcgatgcag    120

agctgagtga aaaggggacc gaggaggcca agcggggagc caaggccatc aaggatgcca    180

agatggagtt tgacatctgc tacacgtcag tgctgaagcg ggccatccgc accctctggg    240

ccatcctgga cggcacggac cagatgtggc tgcctgtggt gcgcacttgg cgcctcaatg    300

agcggcatta cgggggcctc acaggcctca acaaggcaga aacggccgcc aagcacgggg    360

aggagcaggt gaagatctgg aggcgctcct tcgacatccc gccgcccccg atggacgaga    420

agcaccccta ctacaactcc attagcaagg agcgtcggta cgcaggcctg aagcccgggg    480

aactccccac ctgcgagagc ctcaaggaca ccattgcccg ggccctgccc ttctggaacg    540

aggagattgt tccccagatc aaggccggca agcgagtgct cattgcagcc cacgggaaca    600

gcctgcgggg cattgtcaag cacctggaag ggatgtcaga ccaggcgatc atggagctga    660

acctgcccac ggggatcccc attgtgtatg agctgaacaa ggagctgaag cccaccaagc    720

ccatgcagtt cctgggtgat gaggaaacgg tgcggaaggc catggaggct gtggctgccc    780

agggcaaggc caagtgaggg gtgggcttgg gcaataaagg cacctccccc aacaaaaaaa    840

aaaaa                                                                845


<210>  1980
<211>  253
<212>  PRT
<213>  Homosapiens

<400>  1980

Met Ala Thr His Arg Leu Val Met Val Arg His Gly Glu Ser Thr Trp 
1               5                   10                  15      


Asn Gln Glu Asn Arg Phe Cys Gly Trp Phe Asp Ala Glu Leu Ser Glu 
            20                  25                  30          


Lys Gly Thr Glu Glu Ala Lys Arg Gly Ala Lys Ala Ile Lys Asp Ala 
        35                  40                  45              


Lys Met Glu Phe Asp Ile Cys Tyr Thr Ser Val Leu Lys Arg Ala Ile 
    50                  55                  60                  


Arg Thr Leu Trp Ala Ile Leu Asp Gly Thr Asp Gln Met Trp Leu Pro 
65                  70                  75                  80  


Val Val Arg Thr Trp Arg Leu Asn Glu Arg His Tyr Gly Gly Leu Thr 
                85                  90                  95      


Gly Leu Asn Lys Ala Glu Thr Ala Ala Lys His Gly Glu Glu Gln Val 
            100                 105                 110         


Lys Ile Trp Arg Arg Ser Phe Asp Ile Pro Pro Pro Pro Met Asp Glu 
        115                 120                 125             


Lys His Pro Tyr Tyr Asn Ser Ile Ser Lys Glu Arg Arg Tyr Ala Gly 
    130                 135                 140                 


Leu Lys Pro Gly Glu Leu Pro Thr Cys Glu Ser Leu Lys Asp Thr Ile 
145                 150                 155                 160 


Ala Arg Ala Leu Pro Phe Trp Asn Glu Glu Ile Val Pro Gln Ile Lys 
                165                 170                 175     


Ala Gly Lys Arg Val Leu Ile Ala Ala His Gly Asn Ser Leu Arg Gly 
            180                 185                 190         


Ile Val Lys His Leu Glu Gly Met Ser Asp Gln Ala Ile Met Glu Leu 
        195                 200                 205             


Asn Leu Pro Thr Gly Ile Pro Ile Val Tyr Glu Leu Asn Lys Glu Leu 
    210                 215                 220                 


Lys Pro Thr Lys Pro Met Gln Phe Leu Gly Asp Glu Glu Thr Val Arg 
225                 230                 235                 240 


Lys Ala Met Glu Ala Val Ala Ala Gln Gly Lys Ala Lys 
                245                 250             


<210>  1981
<211>  2589
<212>  DNA
<213>  Homosapiens

<400>  1981
gtttccctct gcgttcgctc cgcgctgctg gaggctgtcg tcccaatgct ccccaaacgg     60

cggcgagcgc gggtcgggtc ccctagcggc gatgccgctt cctccacgcc gccctcgacg    120

cgcttcccgg gagtcgccat ctacctggtc gagcctcgca tgggtcgcag ccgccgggcc    180

ttcctcacag gcctggcgcg ctccaaaggc ttccgcgtcc ttgacgcctg cagctccgaa    240

gcgacacatg ttgtgatgga agagacctca gcagaggagg ccgtcagctg gcaggagcgc    300

aggatggcag ctgctccccc gggttgcacc cccccagctc tgctggacat aagctggtta    360

acagagagcc tgggagctgg gcagcctgta cctgtggagt gccggcaccg cctggaggtg    420

gctgggccaa ggaaggggcc tctgagccca gcatggatgc ctgcctatgc ctgccagcgc    480

cctacgcccc tcacacacca caacactggc ctctccgagg ctctggagat actggccgag    540

gcagcaggct ttgaaggcag tgagggccgc ctcctcacct tctgcagagc agcctcggtg    600

ctcaaggccc ttcccagccc tgtcacaacc ctgagccagc tgcaggggct tccccacttt    660

ggagaacact cctctagggt tgtccaggag ctgctggagc atggagtgtg tgaggaggtg    720

gagagagttc ggcgctcaga gaggtaccag accatgaagc tcttcaccca gatcttcggg    780

gtcggtgtga agactgctga ccggtggtac cgggaaggac tgcgaacctt agatgacctc    840

cgagagcagc cccagaaact aacccaacag cagaaagcgg ggctccagca ccaccaggac    900

ctgagcaccc cagtcctgcg gtccgatgta gatgccctgc agcaggtggt ggaggaagct    960

gtggggcagg ccctgcctgg ggccaccgtc acgctgaccg gcggcttccg cagggggaag   1020

ttgcagggcc atgacgtgga cttcctcatc acccacccca aggagggtca ggaggcgggg   1080

ctgctgccta gagtgatgtg ccgcctgcag gaccagggcc tcatcctgta ccaccagcac   1140

cagcacagct gctgtgagtc ccctacccgc ctggcccaac agagccacat ggacgctttt   1200

gagagaagtt tctgcatttt ccgcctacca caacctccag gggctgctgt ggggggatcc   1260

acgaggccct gcccatcctg gaaggccgtg agagtggact tggtagttgc acccgtcagc   1320

cagttccctt tcgccctgct cggttggact ggctccaagc ttttccagcg ggagctgcgc   1380

cgcttcagcc ggaaggagaa gggcctgtgg ctgaacagcc atgggctgtt tgacccggag   1440

cagaagacat ttttccaagc ggcttcagag gaagacatct tcagacacct gggccttgag   1500

taccttcctc cagagcagag aaacgcctga acctgcctgt gtcccccact tccactcagg   1560

aaattgggct gcccccaaac tggccactga atgtctccaa gcaaatatgc tgccccctga   1620

ccccaccttc aaccctcccc gccaaggcct ggctcttccg gaggtcaatt gtgcctgcag   1680

gatcagttga gcccctgctg gtgtgctgca gggtgtgatg aggtgggagc cctcagtgcc   1740

agcctcatca ctgtgtgacc ctgggtctgc tcttagcctc cccatggctc acgttcctgc   1800

cctggatggg atgtgagtgg ggcccacatc gtggagctgt ggtggggcct gcagtcatga   1860

atggcaagtg gtccctgatg tgcagtgtct cattagttgc actgcagtta actgtggctc   1920

ctgcagggca ccctgcccag aatgcccaga agagaaccat gcatacctgc actgcatttg   1980

agagccatga gctggaggct gtggttcgtg ccagcaagga gcctactgtc tggtgtgctg   2040

taggcatctg gagagggaga gggcctgggt aggagctggg aggaagataa ttttcaacta   2100

tggggcttca gtactgcagc gccccgaagc caggctctgt gcttctgcct ttaaggcctg   2160

ttctcagcac aatgtctcaa aaataggtca tatcctgcca ctcccgtcgc agagcccttt   2220

aatggttcca aaccctaagt ccacacatag cccctggctc tggcatctct ccagccccac   2280

tggccccgag ctgcttgact caccggcttc ctatttgatg cacccaggcc cccttgtggc   2340

caactccctc cccttctcac tgaggcagaa gcactgaggt gggctggaca tgggtgccct   2400

ccacgtccct catatcccca ggcacactct ggcctcaggt tttgccctgg ccatgtcatc   2460

tacctggagt gggccctccc cttcttcagg ccttgaatca aaagccactt tgttaggcga   2520

ggatttccca gaccactcat cacattaaaa aatattttga aaacatgcag taaaaaaaaa   2580

aaaaaaaaa                                                           2589


<210>  1982
<211>  494
<212>  PRT
<213>  Homosapiens

<400>  1982

Met Leu Pro Lys Arg Arg Arg Ala Arg Val Gly Ser Pro Ser Gly Asp 
1               5                   10                  15      


Ala Ala Ser Ser Thr Pro Pro Ser Thr Arg Phe Pro Gly Val Ala Ile 
            20                  25                  30          


Tyr Leu Val Glu Pro Arg Met Gly Arg Ser Arg Arg Ala Phe Leu Thr 
        35                  40                  45              


Gly Leu Ala Arg Ser Lys Gly Phe Arg Val Leu Asp Ala Cys Ser Ser 
    50                  55                  60                  


Glu Ala Thr His Val Val Met Glu Glu Thr Ser Ala Glu Glu Ala Val 
65                  70                  75                  80  


Ser Trp Gln Glu Arg Arg Met Ala Ala Ala Pro Pro Gly Cys Thr Pro 
                85                  90                  95      


Pro Ala Leu Leu Asp Ile Ser Trp Leu Thr Glu Ser Leu Gly Ala Gly 
            100                 105                 110         


Gln Pro Val Pro Val Glu Cys Arg His Arg Leu Glu Val Ala Gly Pro 
        115                 120                 125             


Arg Lys Gly Pro Leu Ser Pro Ala Trp Met Pro Ala Tyr Ala Cys Gln 
    130                 135                 140                 


Arg Pro Thr Pro Leu Thr His His Asn Thr Gly Leu Ser Glu Ala Leu 
145                 150                 155                 160 


Glu Ile Leu Ala Glu Ala Ala Gly Phe Glu Gly Ser Glu Gly Arg Leu 
                165                 170                 175     


Leu Thr Phe Cys Arg Ala Ala Ser Val Leu Lys Ala Leu Pro Ser Pro 
            180                 185                 190         


Val Thr Thr Leu Ser Gln Leu Gln Gly Leu Pro His Phe Gly Glu His 
        195                 200                 205             


Ser Ser Arg Val Val Gln Glu Leu Leu Glu His Gly Val Cys Glu Glu 
    210                 215                 220                 


Val Glu Arg Val Arg Arg Ser Glu Arg Tyr Gln Thr Met Lys Leu Phe 
225                 230                 235                 240 


Thr Gln Ile Phe Gly Val Gly Val Lys Thr Ala Asp Arg Trp Tyr Arg 
                245                 250                 255     


Glu Gly Leu Arg Thr Leu Asp Asp Leu Arg Glu Gln Pro Gln Lys Leu 
            260                 265                 270         


Thr Gln Gln Gln Lys Ala Gly Leu Gln His His Gln Asp Leu Ser Thr 
        275                 280                 285             


Pro Val Leu Arg Ser Asp Val Asp Ala Leu Gln Gln Val Val Glu Glu 
    290                 295                 300                 


Ala Val Gly Gln Ala Leu Pro Gly Ala Thr Val Thr Leu Thr Gly Gly 
305                 310                 315                 320 


Phe Arg Arg Gly Lys Leu Gln Gly His Asp Val Asp Phe Leu Ile Thr 
                325                 330                 335     


His Pro Lys Glu Gly Gln Glu Ala Gly Leu Leu Pro Arg Val Met Cys 
            340                 345                 350         


Arg Leu Gln Asp Gln Gly Leu Ile Leu Tyr His Gln His Gln His Ser 
        355                 360                 365             


Cys Cys Glu Ser Pro Thr Arg Leu Ala Gln Gln Ser His Met Asp Ala 
    370                 375                 380                 


Phe Glu Arg Ser Phe Cys Ile Phe Arg Leu Pro Gln Pro Pro Gly Ala 
385                 390                 395                 400 


Ala Val Gly Gly Ser Thr Arg Pro Cys Pro Ser Trp Lys Ala Val Arg 
                405                 410                 415     


Val Asp Leu Val Val Ala Pro Val Ser Gln Phe Pro Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Lys Leu Phe Gln Arg Glu Leu Arg Arg Phe Ser 
        435                 440                 445             


Arg Lys Glu Lys Gly Leu Trp Leu Asn Ser His Gly Leu Phe Asp Pro 
    450                 455                 460                 


Glu Gln Lys Thr Phe Phe Gln Ala Ala Ser Glu Glu Asp Ile Phe Arg 
465                 470                 475                 480 


His Leu Gly Leu Glu Tyr Leu Pro Pro Glu Gln Arg Asn Ala 
                485                 490                 


<210>  1983
<211>  4125
<212>  DNA
<213>  Homosapiens

<400>  1983
cggctatccg cgcgggagtg cgccacgcgg ggccggagcg cctattagcc gccaggacct     60

cggagcgccc cgaccacccc tgagcccctc tggcttcgga gccccccagc accccttccc    120

gggtcccctc gcccacccta atccactctc cctccctttc ccggattccc tcgctcaccc    180

catcctctct cccgcccctt cctggattcc ctcacccgtc tcgatcccct ctccgccctt    240

tcccagagac ccagagcccc tgaccccccg cgccctcccc ggagcccccc gcgcgtgccg    300

cggccatggc ggccgtgcgc ggggcgcccc tgctcagctg cctcctggcg ttgctggccc    360

tgtgccctgg agggcgcccg cagacggtgc tgaccgacga cgagatcgag gagttcctcg    420

agggcttcct gtcagagcta gaacctgagc cccgggagga cgacgtggag gccccgccgc    480

ctcccgagcc caccccgcgg gtccgaaaag cccaggcggg gggcaagcca gggaagcggc    540

cagggacggc cgcagaagtg cctccggaaa agaccaaaga caaagggaag aaaggcaaga    600

aagacaaagg ccccaaggtg cccaaggagt ccttggaggg gtcccccagg ccgcccaaga    660

aggggaagga gaagccaccc aaggccacca agaagcccaa ggagaagcca cctaaggcca    720

ccaagaagcc caaggagaag ccacccaagg ccaccaagaa gcccaaagag aagccaccca    780

aggccaccaa gaagcccccg tcagggaaga ggccccccat tctggctccc tcagaaaccc    840

tggagtggcc actgccccca ccccccagcc ctggccccga ggagctaccc caggagggag    900

gggcgcccct ctcaaataac tggcagaatc caggagagga gacccatgtg gaggcacggg    960

agcaccagcc tgagccggag gaggagaccg agcaacccac actggactac aatgaccaga   1020

tcgagaggga ggactatgag gactttgagt acattcggcg ccagaagcaa cccaggccac   1080

ccccaagcag aaggaggagg cccgagcggg tctggccaga gccccctgag gagaaggccc   1140

cggccccagc cccggaggag aggattgagc ctcctgtgaa gcctctgctg cccccgctgc   1200

cccctgacta tggtgatggt tacgtgatcc ccaactacga tgacatggac tattactttg   1260

ggcctcctcc gccccagaag cccgatgctg agcgccagac ggacgaagag aaggaggagc   1320

tgaagaaacc caaaaaggag gacagcagcc ccaaggagga gaccgacaag tgggcagtgg   1380

agaagggcaa ggaccacaaa gagccccgaa agggcgagga gttggaggag gagtggacgc   1440

ctacggagaa agtcaagtgt ccccccattg ggatggagtc acaccgtatt gaggacaacc   1500

agatccgagc ctcctccatg ctgcgccacg gcctgggggc acagcgcggc cggctcaaca   1560

tgcagaccgg tgccactgag gacgactact atgatggtgc gtggtgtgcc gaggacgatg   1620

ccaggaccca gtggatagag gtggacacca ggaggactac ccggttcaca ggcgtcatca   1680

cccagggcag agactccagc atccatgacg attttgtgac caccttcttc gtgggcttca   1740

gcaatgacag ccagacatgg gtgatgtaca ccaacggcta tgaggaaatg acctttcatg   1800

ggaacgtgga caaggacaca cccgtgctga gtgagctccc agagccggtg gtggctcgtt   1860

tcatccgcat ctacccactc acctggaatg gcagcctgtg catgcgcctg gaggtgctgg   1920

ggtgctctgt ggcccctgtc tacagctact acgcacagaa tgaggtggtg gccaccgatg   1980

acctggattt ccggcaccac agctacaagg acatgcgcca gctcatgaag gtggtgaacg   2040

aggagtgccc caccatcacc cgcacttaca gcctgggcaa gagctcacga ggcctcaaga   2100

tctatgccat ggagatctca gacaaccctg gggagcatga actgggggag cccgagttcc   2160

gctacactgc tgggatccat ggcaacgagg tgctgggccg agagctgttg ctgctgctca   2220

tgcagtacct gtgccgagag taccgcgatg ggaacccacg tgtgcgcagc ctggtgcagg   2280

acacacgcat ccacctggtg ccctcactga accctgatgg ctacgaggtg gcagcgcaga   2340

tgggctcaga gtttgggaac tgggcgctgg gactgtggac tgaggagggc tttgacatct   2400

ttgaagattt cccggatctc aactctgtgc tctggggagc tgaggagagg aaatgggtcc   2460

cctaccgggt ccccaacaat aacttgccca tccctgaacg ctacctttcg ccagatgcca   2520

cggtatccac ggaggtccgg gccatcattg cctggatgga gaagaacccc ttcgtgctgg   2580

gagcaaatct gaacggcggc gagcggctag tatcctaccc ctacgatatg gcccgcacgc   2640

ctacccagga gcagctgctg gccgcagcca tggcagcagc ccggggggag gatgaggacg   2700

aggtctccga ggcccaggag actccagacc acgccatctt ccggtggctt gccatctcct   2760

tcgcctccgc acacctcacc ttgaccgagc cctaccgcgg aggctgccaa gcccaggact   2820

acaccggcgg catgggcatc gtcaacgggg ccaagtggaa cccccggacc gggactatca   2880

atgacttcag ttacctgcat accaactgcc tggagctctc cttctacctg ggctgtgaca   2940

agttccctca tgagagtgag ctgccccgcg agtgggagaa caacaaggag gcgctgctca   3000

ccttcatgga gcaggtgcac cgcggcatta agggggtggt gacggacgag caaggcatcc   3060

ccattgccaa cgccaccatc tctgtgagtg gcattaatca cggcgtgaag acagccagtg   3120

gtggtgatta ctggcgaatc ttgaacccgg gtgagtaccg cgtgacagcc cacgcggagg   3180

gctacacccc gagcgccaag acctgcaatg ttgactatga catcggggcc actcagtgca   3240

acttcatcct ggctcgctcc aactggaagc gcatccggga gatcatggcc atgaacggga   3300

accggcctat cccacacata gacccatcgc gccctatgac cccccaacag cgacgcctgc   3360

agcagcgacg cctacaacac cgcctgcggc ttcgggcaca gatgcggctg cggcgcctca   3420

acgccaccac caccctaggc ccccacactg tgcctcccac gctgccccct gcccctgcca   3480

ccaccctgag cactaccata gagccctggg gcctcatacc gccaaccacc gctggctggg   3540

aggagtcgga gactgagacc tacacagagg tggtgacaga gtttgggacc gaggtggagc   3600

ccgagtttgg gaccaaggtg gagcccgagt ttgagaccca gttggagcct gagtttgaga   3660

cccagctgga acccgagttt gaggaagagg aggaggagga gaaagaggag gagatagcca   3720

ctggccaggc attccccttc acaacagtag agacctacac agtgaacttt ggggacttct   3780

gagatcagcg tcctaccaag accccagccc aactcaagct acagcagcag cacttcccaa   3840

gcctgctgac cacagtcaca tcacccatca gcacatggaa ggcccctggt atggacactg   3900

aaaggaaggg ctggtcctgc ccctttgagg gggtgcaaac atgactggga cctaagagcc   3960

agaggctgtg tagaggctcc tgctccacct gccagtctcg taagagatgg ggttgctgca   4020

gtgttggagt aggggcagag ggagggagcc aaggtcactc caataaaaca agctcatggc   4080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                   4125


<210>  1984
<211>  1158
<212>  PRT
<213>  Homosapiens

<400>  1984

Met Ala Ala Val Arg Gly Ala Pro Leu Leu Ser Cys Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Cys Pro Gly Gly Arg Pro Gln Thr Val Leu Thr Asp Asp 
            20                  25                  30          


Glu Ile Glu Glu Phe Leu Glu Gly Phe Leu Ser Glu Leu Glu Pro Glu 
        35                  40                  45              


Pro Arg Glu Asp Asp Val Glu Ala Pro Pro Pro Pro Glu Pro Thr Pro 
    50                  55                  60                  


Arg Val Arg Lys Ala Gln Ala Gly Gly Lys Pro Gly Lys Arg Pro Gly 
65                  70                  75                  80  


Thr Ala Ala Glu Val Pro Pro Glu Lys Thr Lys Asp Lys Gly Lys Lys 
                85                  90                  95      


Gly Lys Lys Asp Lys Gly Pro Lys Val Pro Lys Glu Ser Leu Glu Gly 
            100                 105                 110         


Ser Pro Arg Pro Pro Lys Lys Gly Lys Glu Lys Pro Pro Lys Ala Thr 
        115                 120                 125             


Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu 
    130                 135                 140                 


Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala 
145                 150                 155                 160 


Thr Lys Lys Pro Pro Ser Gly Lys Arg Pro Pro Ile Leu Ala Pro Ser 
                165                 170                 175     


Glu Thr Leu Glu Trp Pro Leu Pro Pro Pro Pro Ser Pro Gly Pro Glu 
            180                 185                 190         


Glu Leu Pro Gln Glu Gly Gly Ala Pro Leu Ser Asn Asn Trp Gln Asn 
        195                 200                 205             


Pro Gly Glu Glu Thr His Val Glu Ala Arg Glu His Gln Pro Glu Pro 
    210                 215                 220                 


Glu Glu Glu Thr Glu Gln Pro Thr Leu Asp Tyr Asn Asp Gln Ile Glu 
225                 230                 235                 240 


Arg Glu Asp Tyr Glu Asp Phe Glu Tyr Ile Arg Arg Gln Lys Gln Pro 
                245                 250                 255     


Arg Pro Pro Pro Ser Arg Arg Arg Arg Pro Glu Arg Val Trp Pro Glu 
            260                 265                 270         


Pro Pro Glu Glu Lys Ala Pro Ala Pro Ala Pro Glu Glu Arg Ile Glu 
        275                 280                 285             


Pro Pro Val Lys Pro Leu Leu Pro Pro Leu Pro Pro Asp Tyr Gly Asp 
    290                 295                 300                 


Gly Tyr Val Ile Pro Asn Tyr Asp Asp Met Asp Tyr Tyr Phe Gly Pro 
305                 310                 315                 320 


Pro Pro Pro Gln Lys Pro Asp Ala Glu Arg Gln Thr Asp Glu Glu Lys 
                325                 330                 335     


Glu Glu Leu Lys Lys Pro Lys Lys Glu Asp Ser Ser Pro Lys Glu Glu 
            340                 345                 350         


Thr Asp Lys Trp Ala Val Glu Lys Gly Lys Asp His Lys Glu Pro Arg 
        355                 360                 365             


Lys Gly Glu Glu Leu Glu Glu Glu Trp Thr Pro Thr Glu Lys Val Lys 
    370                 375                 380                 


Cys Pro Pro Ile Gly Met Glu Ser His Arg Ile Glu Asp Asn Gln Ile 
385                 390                 395                 400 


Arg Ala Ser Ser Met Leu Arg His Gly Leu Gly Ala Gln Arg Gly Arg 
                405                 410                 415     


Leu Asn Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala 
            420                 425                 430         


Trp Cys Ala Glu Asp Asp Ala Arg Thr Gln Trp Ile Glu Val Asp Thr 
        435                 440                 445             


Arg Arg Thr Thr Arg Phe Thr Gly Val Ile Thr Gln Gly Arg Asp Ser 
    450                 455                 460                 


Ser Ile His Asp Asp Phe Val Thr Thr Phe Phe Val Gly Phe Ser Asn 
465                 470                 475                 480 


Asp Ser Gln Thr Trp Val Met Tyr Thr Asn Gly Tyr Glu Glu Met Thr 
                485                 490                 495     


Phe His Gly Asn Val Asp Lys Asp Thr Pro Val Leu Ser Glu Leu Pro 
            500                 505                 510         


Glu Pro Val Val Ala Arg Phe Ile Arg Ile Tyr Pro Leu Thr Trp Asn 
        515                 520                 525             


Gly Ser Leu Cys Met Arg Leu Glu Val Leu Gly Cys Ser Val Ala Pro 
    530                 535                 540                 


Val Tyr Ser Tyr Tyr Ala Gln Asn Glu Val Val Ala Thr Asp Asp Leu 
545                 550                 555                 560 


Asp Phe Arg His His Ser Tyr Lys Asp Met Arg Gln Leu Met Lys Val 
                565                 570                 575     


Val Asn Glu Glu Cys Pro Thr Ile Thr Arg Thr Tyr Ser Leu Gly Lys 
            580                 585                 590         


Ser Ser Arg Gly Leu Lys Ile Tyr Ala Met Glu Ile Ser Asp Asn Pro 
        595                 600                 605             


Gly Glu His Glu Leu Gly Glu Pro Glu Phe Arg Tyr Thr Ala Gly Ile 
    610                 615                 620                 


His Gly Asn Glu Val Leu Gly Arg Glu Leu Leu Leu Leu Leu Met Gln 
625                 630                 635                 640 


Tyr Leu Cys Arg Glu Tyr Arg Asp Gly Asn Pro Arg Val Arg Ser Leu 
                645                 650                 655     


Val Gln Asp Thr Arg Ile His Leu Val Pro Ser Leu Asn Pro Asp Gly 
            660                 665                 670         


Tyr Glu Val Ala Ala Gln Met Gly Ser Glu Phe Gly Asn Trp Ala Leu 
        675                 680                 685             


Gly Leu Trp Thr Glu Glu Gly Phe Asp Ile Phe Glu Asp Phe Pro Asp 
    690                 695                 700                 


Leu Asn Ser Val Leu Trp Gly Ala Glu Glu Arg Lys Trp Val Pro Tyr 
705                 710                 715                 720 


Arg Val Pro Asn Asn Asn Leu Pro Ile Pro Glu Arg Tyr Leu Ser Pro 
                725                 730                 735     


Asp Ala Thr Val Ser Thr Glu Val Arg Ala Ile Ile Ala Trp Met Glu 
            740                 745                 750         


Lys Asn Pro Phe Val Leu Gly Ala Asn Leu Asn Gly Gly Glu Arg Leu 
        755                 760                 765             


Val Ser Tyr Pro Tyr Asp Met Ala Arg Thr Pro Thr Gln Glu Gln Leu 
    770                 775                 780                 


Leu Ala Ala Ala Met Ala Ala Ala Arg Gly Glu Asp Glu Asp Glu Val 
785                 790                 795                 800 


Ser Glu Ala Gln Glu Thr Pro Asp His Ala Ile Phe Arg Trp Leu Ala 
                805                 810                 815     


Ile Ser Phe Ala Ser Ala His Leu Thr Leu Thr Glu Pro Tyr Arg Gly 
            820                 825                 830         


Gly Cys Gln Ala Gln Asp Tyr Thr Gly Gly Met Gly Ile Val Asn Gly 
        835                 840                 845             


Ala Lys Trp Asn Pro Arg Thr Gly Thr Ile Asn Asp Phe Ser Tyr Leu 
    850                 855                 860                 


His Thr Asn Cys Leu Glu Leu Ser Phe Tyr Leu Gly Cys Asp Lys Phe 
865                 870                 875                 880 


Pro His Glu Ser Glu Leu Pro Arg Glu Trp Glu Asn Asn Lys Glu Ala 
                885                 890                 895     


Leu Leu Thr Phe Met Glu Gln Val His Arg Gly Ile Lys Gly Val Val 
            900                 905                 910         


Thr Asp Glu Gln Gly Ile Pro Ile Ala Asn Ala Thr Ile Ser Val Ser 
        915                 920                 925             


Gly Ile Asn His Gly Val Lys Thr Ala Ser Gly Gly Asp Tyr Trp Arg 
    930                 935                 940                 


Ile Leu Asn Pro Gly Glu Tyr Arg Val Thr Ala His Ala Glu Gly Tyr 
945                 950                 955                 960 


Thr Pro Ser Ala Lys Thr Cys Asn Val Asp Tyr Asp Ile Gly Ala Thr 
                965                 970                 975     


Gln Cys Asn Phe Ile Leu Ala Arg Ser Asn Trp Lys Arg Ile Arg Glu 
            980                 985                 990         


Ile Met Ala Met Asn Gly Asn Arg  Pro Ile Pro His Ile  Asp Pro Ser 
        995                 1000                 1005             


Arg Pro  Met Thr Pro Gln Gln  Arg Arg Leu Gln Gln  Arg Arg Leu 
    1010                 1015                 1020             


Gln His  Arg Leu Arg Leu Arg  Ala Gln Met Arg Leu  Arg Arg Leu 
    1025                 1030                 1035             


Asn Ala  Thr Thr Thr Leu Gly  Pro His Thr Val Pro  Pro Thr Leu 
    1040                 1045                 1050             


Pro Pro  Ala Pro Ala Thr Thr  Leu Ser Thr Thr Ile  Glu Pro Trp 
    1055                 1060                 1065             


Gly Leu  Ile Pro Pro Thr Thr  Ala Gly Trp Glu Glu  Ser Glu Thr 
    1070                 1075                 1080             


Glu Thr  Tyr Thr Glu Val Val  Thr Glu Phe Gly Thr  Glu Val Glu 
    1085                 1090                 1095             


Pro Glu  Phe Gly Thr Lys Val  Glu Pro Glu Phe Glu  Thr Gln Leu 
    1100                 1105                 1110             


Glu Pro  Glu Phe Glu Thr Gln  Leu Glu Pro Glu Phe  Glu Glu Glu 
    1115                 1120                 1125             


Glu Glu  Glu Glu Lys Glu Glu  Glu Ile Ala Thr Gly  Gln Ala Phe 
    1130                 1135                 1140             


Pro Phe  Thr Thr Val Glu Thr  Tyr Thr Val Asn Phe  Gly Asp Phe 
    1145                 1150                 1155             


<210>  1985
<211>  1584
<212>  DNA
<213>  Homosapiens

<400>  1985
cgggatgcgg cgcgccgcgc gttgaacctc cttggcctgg gcgaagctgt gtggaccaag     60

caagtcagga gtgtggccat gttttctgag caggctgccc agagggccca cactctactg    120

tccccaccat cagccaacaa tgccaccttt gcccgggtgc cagtggcaac ctacaccaac    180

tcctcacaac ccttccggct aggagagcgc agctttagcc ggcagtatgc ccacatttat    240

gccacccgcc tcatccaaat gagacccttc ctggagaacc gggcccagca gcactggggc    300

agtggagtgg gagtgaagaa gctgtgtgaa ctgcagcctg aggagaagtg ctgtgtggtg    360

ggcactctgt tcaaggccat gccgctgcag ccctccatcc tgcgggaggt cagcgaggag    420

cacaacctgc tcccccagcc tcctcggagt aaatacatac acccagatga cgagctggtc    480

ttggaagatg aactgcagcg tatcaaacta aaaggcacca ttgacgtgtc aaagctggtt    540

acggggactg tcctggctgt gtttggctcc gtgagagacg acgggaagtt tctggtggag    600

gactattgct ttgctgacct tgctccccag aagcccgcac ccccacttga cacagatagg    660

tttgtgctac tggtgtccgg cctgggcctg ggtggcggtg gaggcgagag cctgctgggc    720

acccagctgc tggtggatgt ggtgacgggg cagcttgggg acgaagggga gcagtgcagc    780

gccgcccacg tctcccgggt tatcctcgct ggcaacctcc tcagccacag cacccagagc    840

agggattcta tcaataaggc caaatacctc accaagaaaa cccaggcagc cagcgtggag    900

gctgttaaga tgctggatga gatcctcctg cagctgagcg cctcagtgcc cgtggacgtg    960

atgccaggcg agtttgatcc caccaattac acgctccccc agcagcccct ccacccctgc   1020

atgttcccgc tggccactgc ctactccacg ctccagctgg tcaccaaccc ctaccaggcc   1080

accattgatg gagtcagatt tttggggaca tcaggacaga acgtgagtga cattttccga   1140

tacagcagca tggaggatca cttggagatc ctggagtgga ccctgcgggt ccgtcacatc   1200

agccccacag ccccggacac tctaggttgt taccccttct acaaaactga cccgttcatc   1260

ttcccagagt gcccgcatgt ctacttttgt ggcaacaccc ccagctttgg ctccaaaatc   1320

atccgaggtc ctgaggacca gacagtgctg ttggtgactg tccctgactt cagtgccacg   1380

cagaccgcct gccttgtgaa cctgcgcagc ctggcctgcc agcccatcag cttctcgggc   1440

ttcggggcag aggacgatga cctgggaggc ctggggctgg gcccctgact caaaaaagtg   1500

gttttgacca gagaggccca gatggaggct gttcattccc tgcagtgtcg gcattgtaaa   1560

taaagcctgg cacttgctga tgcg                                          1584


<210>  1986
<211>  469
<212>  PRT
<213>  Homosapiens

<400>  1986

Met Phe Ser Glu Gln Ala Ala Gln Arg Ala His Thr Leu Leu Ser Pro 
1               5                   10                  15      


Pro Ser Ala Asn Asn Ala Thr Phe Ala Arg Val Pro Val Ala Thr Tyr 
            20                  25                  30          


Thr Asn Ser Ser Gln Pro Phe Arg Leu Gly Glu Arg Ser Phe Ser Arg 
        35                  40                  45              


Gln Tyr Ala His Ile Tyr Ala Thr Arg Leu Ile Gln Met Arg Pro Phe 
    50                  55                  60                  


Leu Glu Asn Arg Ala Gln Gln His Trp Gly Ser Gly Val Gly Val Lys 
65                  70                  75                  80  


Lys Leu Cys Glu Leu Gln Pro Glu Glu Lys Cys Cys Val Val Gly Thr 
                85                  90                  95      


Leu Phe Lys Ala Met Pro Leu Gln Pro Ser Ile Leu Arg Glu Val Ser 
            100                 105                 110         


Glu Glu His Asn Leu Leu Pro Gln Pro Pro Arg Ser Lys Tyr Ile His 
        115                 120                 125             


Pro Asp Asp Glu Leu Val Leu Glu Asp Glu Leu Gln Arg Ile Lys Leu 
    130                 135                 140                 


Lys Gly Thr Ile Asp Val Ser Lys Leu Val Thr Gly Thr Val Leu Ala 
145                 150                 155                 160 


Val Phe Gly Ser Val Arg Asp Asp Gly Lys Phe Leu Val Glu Asp Tyr 
                165                 170                 175     


Cys Phe Ala Asp Leu Ala Pro Gln Lys Pro Ala Pro Pro Leu Asp Thr 
            180                 185                 190         


Asp Arg Phe Val Leu Leu Val Ser Gly Leu Gly Leu Gly Gly Gly Gly 
        195                 200                 205             


Gly Glu Ser Leu Leu Gly Thr Gln Leu Leu Val Asp Val Val Thr Gly 
    210                 215                 220                 


Gln Leu Gly Asp Glu Gly Glu Gln Cys Ser Ala Ala His Val Ser Arg 
225                 230                 235                 240 


Val Ile Leu Ala Gly Asn Leu Leu Ser His Ser Thr Gln Ser Arg Asp 
                245                 250                 255     


Ser Ile Asn Lys Ala Lys Tyr Leu Thr Lys Lys Thr Gln Ala Ala Ser 
            260                 265                 270         


Val Glu Ala Val Lys Met Leu Asp Glu Ile Leu Leu Gln Leu Ser Ala 
        275                 280                 285             


Ser Val Pro Val Asp Val Met Pro Gly Glu Phe Asp Pro Thr Asn Tyr 
    290                 295                 300                 


Thr Leu Pro Gln Gln Pro Leu His Pro Cys Met Phe Pro Leu Ala Thr 
305                 310                 315                 320 


Ala Tyr Ser Thr Leu Gln Leu Val Thr Asn Pro Tyr Gln Ala Thr Ile 
                325                 330                 335     


Asp Gly Val Arg Phe Leu Gly Thr Ser Gly Gln Asn Val Ser Asp Ile 
            340                 345                 350         


Phe Arg Tyr Ser Ser Met Glu Asp His Leu Glu Ile Leu Glu Trp Thr 
        355                 360                 365             


Leu Arg Val Arg His Ile Ser Pro Thr Ala Pro Asp Thr Leu Gly Cys 
    370                 375                 380                 


Tyr Pro Phe Tyr Lys Thr Asp Pro Phe Ile Phe Pro Glu Cys Pro His 
385                 390                 395                 400 


Val Tyr Phe Cys Gly Asn Thr Pro Ser Phe Gly Ser Lys Ile Ile Arg 
                405                 410                 415     


Gly Pro Glu Asp Gln Thr Val Leu Leu Val Thr Val Pro Asp Phe Ser 
            420                 425                 430         


Ala Thr Gln Thr Ala Cys Leu Val Asn Leu Arg Ser Leu Ala Cys Gln 
        435                 440                 445             


Pro Ile Ser Phe Ser Gly Phe Gly Ala Glu Asp Asp Asp Leu Gly Gly 
    450                 455                 460                 


Leu Gly Leu Gly Pro 
465                 


<210>  1987
<211>  619
<212>  DNA
<213>  Homosapiens

<400>  1987
tctgcagaga gaatggccag caggaaggcg gggacccggg gcaaggtggc agccaccaag     60

caggcccaac gtggttcttc caacgtcttt tccatgtttg aacaagccca gatacaggag    120

ttcaaagaag ccttcagctg tatcgaccag aatcgtgatg gcatcatctg caaggcagac    180

ctgagggaga cctactccca gctggggaag gtgagtgtcc cagaggagga gctggacgcc    240

atgctgcaag agggcaaggg ccccatcaac ttcaccgtct tcctcacgct ctttggggag    300

aagctcaatg ggacagaccc cgaggaagcc atcctgagtg ccttccgcat gtttgacccc    360

agcggcaaag gggtggtgaa caaggatgag ttcaagcagc ttctcctgac ccaggcagac    420

aagttctctc cagctgaggt ggagcagatg ttcgccctga cacccatgga cctggcgggg    480

aacatcgact acaagtcact gtgctacatc atcacccatg gagacgagaa agaggaatga    540

ggggcagggc caggcccacg ggggggcacc tcaataaact ctgttgcaaa attggaaaaa    600

aaaaaaaaaa aaaaaaaaa                                                 619


<210>  1988
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  1988

Met Ala Ser Arg Lys Ala Gly Thr Arg Gly Lys Val Ala Ala Thr Lys 
1               5                   10                  15      


Gln Ala Gln Arg Gly Ser Ser Asn Val Phe Ser Met Phe Glu Gln Ala 
            20                  25                  30          


Gln Ile Gln Glu Phe Lys Glu Ala Phe Ser Cys Ile Asp Gln Asn Arg 
        35                  40                  45              


Asp Gly Ile Ile Cys Lys Ala Asp Leu Arg Glu Thr Tyr Ser Gln Leu 
    50                  55                  60                  


Gly Lys Val Ser Val Pro Glu Glu Glu Leu Asp Ala Met Leu Gln Glu 
65                  70                  75                  80  


Gly Lys Gly Pro Ile Asn Phe Thr Val Phe Leu Thr Leu Phe Gly Glu 
                85                  90                  95      


Lys Leu Asn Gly Thr Asp Pro Glu Glu Ala Ile Leu Ser Ala Phe Arg 
            100                 105                 110         


Met Phe Asp Pro Ser Gly Lys Gly Val Val Asn Lys Asp Glu Phe Lys 
        115                 120                 125             


Gln Leu Leu Leu Thr Gln Ala Asp Lys Phe Ser Pro Ala Glu Val Glu 
    130                 135                 140                 


Gln Met Phe Ala Leu Thr Pro Met Asp Leu Ala Gly Asn Ile Asp Tyr 
145                 150                 155                 160 


Lys Ser Leu Cys Tyr Ile Ile Thr His Gly Asp Glu Lys Glu Glu 
                165                 170                 175 


<210>  1989
<211>  2759
<212>  DNA
<213>  Homosapiens

<400>  1989
actccacacc tggctggagc aggaaatgcc gagcggcgcc tgagccccag ggaagcaggc     60

taggatgtga gagacacagt cacctgcagc ctaattactc aaaagctgtc cccaggtcac    120

agaagggaga ggacatttcc cactgaatct gtctgaagga cactaagccc cacagctcaa    180

cacaaccagg agagaaagcg ctgaggacgc cacccaagcg cccagcaatg gccctgcctg    240

gagaacatcc aggctcagtg aggaagggtc cagaagggaa tgcttgccga ctcgttggag    300

aacaatgaaa aggaggaaac tgtgactgaa cctcaaaccc caaaccagcc cgaggagaac    360

cacattctcc cagggaccca gggcgggccg tgacccctgc ggcggagaag ccttggatat    420

ttccacttca gaagcctact ggggaaggct gaggggtccc agctccccac gctggctgct    480

gtgcagatgc tggacgacag agccaggatg gaggccgcca agaaggagaa ggtagagcag    540

atcctggcag agttccagct gcaggaggag gacctgaaga aggtgatgag acggatgcag    600

aaggagatgg accgcggcct gaggctggag acccatgaag aggccagtgt gaagatgctg    660

cccacctacg tgcgctccac cccagaaggc tcagaagtcg gggacttcct ctccctggac    720

ctgggtggca ctaacttcag ggtgatgctg gtgaaggtgg gagaaggtga ggaggggcag    780

tggagcgtga agaccaaaca ccagatgtac tccatccccg aggacgccat gaccggcact    840

gctgagatgc tcttcgacta catctctgag tgcatctccg acttcctgga caagcatcag    900

atgaaacaca agaagctgcc cctgggcttc accttctcct ttcctgtgag gcacgaagac    960

atcgataagg gcatccttct caactggacc aagggcttca aggcctcagg agcagaaggg   1020

aacaatgtcg tggggcttct gcgagacgct atcaaacgga gaggggactt tgaaatggat   1080

gtggtggcaa tggtgaatga cacggtggcc acgatgatct cctgctacta cgaagaccat   1140

cagtgcgagg tcggcatgat cgtgggcacg ggctgcaatg cctgctacat ggaggagatg   1200

cagaatgtgg agctggtgga gggggacgag ggccgcatgt gcgtcaatac cgagtggggc   1260

gccttcgggg actccggcga gctggacgag ttcctgctgg agtatgaccg cctggtggac   1320

gagagctctg caaaccccgg tcagcagctg tatgagaagc tcataggtgg caagtacatg   1380

ggcgagctgg tgcggcttgt gctgctcagg ctcgtggacg aaaacctgct cttccacggg   1440

gaggcctccg agcagctgcg cacacgcgga gccttcgaga cgcgcttcgt gtcgcaggtg   1500

gagagcgaca cgggcgaccg caagcagatc tacaacatcc tgagcacgct ggggctgcga   1560

ccctcgacca ccgactgcga catcgtgcgc cgcgcctgcg agagcgtgtc tacgcgcgct   1620

gcgcacatgt gctcggcggg gctggcgggc gtcatcaacc gcatgcgcga gagccgcagc   1680

gaggacgtaa tgcgcatcac tgtgggcgtg gatggctccg tgtacaagct gcaccccagc   1740

ttcaaggagc ggttccatgc cagcgtgcgc aggctgacgc ccagctgcga gatcaccttc   1800

atcgagtcgg aggagggcag tggccggggc gcggccctgg tctcggcggt ggcctgtaag   1860

aaggcctgta tgctgggcca gtgagagcag tggccgcaag cgcagggagg atgccacagc   1920

cccacagcac ccaggctcca tggggaagtg ctccccacac gtgctcgcag cctggcgggg   1980

caggaggcct ggccttgtca ggacccaggc cgcctgccat accgctgggg aacagagcgg   2040

gcctcttccc tcagtttttc ggtgggacag ccccagggcc ctaacggggg tgcggcagga   2100

gcaggaacag agactctgga agccccccac ctttctcgct ggaatcaatt tcccagaagg   2160

gagttgctca ctcaggactt tgatgcattt ccacactgtc agagctgttg gcctcgcctg   2220

ggcccaggct ctgggaaggg gtgccctctg gatcctgctg tggcctcact tccctgggaa   2280

ctcatcctgt gtggggaggc agctccaaca gcttgaccag acctagacct gggccaaaag   2340

ggcaggccag gggctgctca tcacccagtc ctggccattt tcttgcctga ggctcaagag   2400

gcccagggag caatgggagg gggctccatg gaggaggtgt cccaagcttt gaataccccc   2460

cagagacctt ttctctccca taccatcact gagtggcttg tgattctggg atggaccctc   2520

gcagcaggtg caagagacag agcccccaag cctctgcccc aaggggccca caaaggggag   2580

aagggccagc cctacatctt cagctcccat agcgctggct caggaagaaa ccccaagcag   2640

cattcagcac accccaaggg acaaccccat catatgacat gccaccctct ccatgcccaa   2700

cctaagattg tgtgggtttt ttaattaaaa atgttaaaag ttttaaacat gaaaaaaaa    2759


<210>  1990
<211>  465
<212>  PRT
<213>  Homosapiens

<400>  1990

Met Leu Asp Asp Arg Ala Arg Met Glu Ala Ala Lys Lys Glu Lys Val 
1               5                   10                  15      


Glu Gln Ile Leu Ala Glu Phe Gln Leu Gln Glu Glu Asp Leu Lys Lys 
            20                  25                  30          


Val Met Arg Arg Met Gln Lys Glu Met Asp Arg Gly Leu Arg Leu Glu 
        35                  40                  45              


Thr His Glu Glu Ala Ser Val Lys Met Leu Pro Thr Tyr Val Arg Ser 
    50                  55                  60                  


Thr Pro Glu Gly Ser Glu Val Gly Asp Phe Leu Ser Leu Asp Leu Gly 
65                  70                  75                  80  


Gly Thr Asn Phe Arg Val Met Leu Val Lys Val Gly Glu Gly Glu Glu 
                85                  90                  95      


Gly Gln Trp Ser Val Lys Thr Lys His Gln Met Tyr Ser Ile Pro Glu 
            100                 105                 110         


Asp Ala Met Thr Gly Thr Ala Glu Met Leu Phe Asp Tyr Ile Ser Glu 
        115                 120                 125             


Cys Ile Ser Asp Phe Leu Asp Lys His Gln Met Lys His Lys Lys Leu 
    130                 135                 140                 


Pro Leu Gly Phe Thr Phe Ser Phe Pro Val Arg His Glu Asp Ile Asp 
145                 150                 155                 160 


Lys Gly Ile Leu Leu Asn Trp Thr Lys Gly Phe Lys Ala Ser Gly Ala 
                165                 170                 175     


Glu Gly Asn Asn Val Val Gly Leu Leu Arg Asp Ala Ile Lys Arg Arg 
            180                 185                 190         


Gly Asp Phe Glu Met Asp Val Val Ala Met Val Asn Asp Thr Val Ala 
        195                 200                 205             


Thr Met Ile Ser Cys Tyr Tyr Glu Asp His Gln Cys Glu Val Gly Met 
    210                 215                 220                 


Ile Val Gly Thr Gly Cys Asn Ala Cys Tyr Met Glu Glu Met Gln Asn 
225                 230                 235                 240 


Val Glu Leu Val Glu Gly Asp Glu Gly Arg Met Cys Val Asn Thr Glu 
                245                 250                 255     


Trp Gly Ala Phe Gly Asp Ser Gly Glu Leu Asp Glu Phe Leu Leu Glu 
            260                 265                 270         


Tyr Asp Arg Leu Val Asp Glu Ser Ser Ala Asn Pro Gly Gln Gln Leu 
        275                 280                 285             


Tyr Glu Lys Leu Ile Gly Gly Lys Tyr Met Gly Glu Leu Val Arg Leu 
    290                 295                 300                 


Val Leu Leu Arg Leu Val Asp Glu Asn Leu Leu Phe His Gly Glu Ala 
305                 310                 315                 320 


Ser Glu Gln Leu Arg Thr Arg Gly Ala Phe Glu Thr Arg Phe Val Ser 
                325                 330                 335     


Gln Val Glu Ser Asp Thr Gly Asp Arg Lys Gln Ile Tyr Asn Ile Leu 
            340                 345                 350         


Ser Thr Leu Gly Leu Arg Pro Ser Thr Thr Asp Cys Asp Ile Val Arg 
        355                 360                 365             


Arg Ala Cys Glu Ser Val Ser Thr Arg Ala Ala His Met Cys Ser Ala 
    370                 375                 380                 


Gly Leu Ala Gly Val Ile Asn Arg Met Arg Glu Ser Arg Ser Glu Asp 
385                 390                 395                 400 


Val Met Arg Ile Thr Val Gly Val Asp Gly Ser Val Tyr Lys Leu His 
                405                 410                 415     


Pro Ser Phe Lys Glu Arg Phe His Ala Ser Val Arg Arg Leu Thr Pro 
            420                 425                 430         


Ser Cys Glu Ile Thr Phe Ile Glu Ser Glu Glu Gly Ser Gly Arg Gly 
        435                 440                 445             


Ala Ala Leu Val Ser Ala Val Ala Cys Lys Lys Ala Cys Met Leu Gly 
    450                 455                 460                 


Gln 
465 


<210>  1991
<211>  2442
<212>  DNA
<213>  Homosapiens

<400>  1991
cctttcagtg cagaagccct gggctgccag cctcaggcag ctctccatcc aagcagccgt     60

tgctgccaca ggcgggcctt acgctccaag gctacagcat gtgctaggcc tcagcaggca    120

ggagcatctc tgcctcccaa agcatctacc tcttagcccc tcggagagat ggcgatggat    180

gtcacaagga gccaggccca gacagccttg actctggtag agcagatcct ggcagagttc    240

cagctgcagg aggaggacct gaagaaggtg atgagacgga tgcagaagga gatggaccgc    300

ggcctgaggc tggagaccca tgaagaggcc agtgtgaaga tgctgcccac ctacgtgcgc    360

tccaccccag aaggctcaga agtcggggac ttcctctccc tggacctggg tggcactaac    420

ttcagggtga tgctggtgaa ggtgggagaa ggtgaggagg ggcagtggag cgtgaagacc    480

aaacaccaga tgtactccat ccccgaggac gccatgaccg gcactgctga gatgctcttc    540

gactacatct ctgagtgcat ctccgacttc ctggacaagc atcagatgaa acacaagaag    600

ctgcccctgg gcttcacctt ctcctttcct gtgaggcacg aagacatcga taagggcatc    660

cttctcaact ggaccaaggg cttcaaggcc tcaggagcag aagggaacaa tgtcgtgggg    720

cttctgcgag acgctatcaa acggagaggg gactttgaaa tggatgtggt ggcaatggtg    780

aatgacacgg tggccacgat gatctcctgc tactacgaag accatcagtg cgaggtcggc    840

atgatcgtgg gcacgggctg caatgcctgc tacatggagg agatgcagaa tgtggagctg    900

gtggaggggg acgagggccg catgtgcgtc aataccgagt ggggcgcctt cggggactcc    960

ggcgagctgg acgagttcct gctggagtat gaccgcctgg tggacgagag ctctgcaaac   1020

cccggtcagc agctgtatga gaagctcata ggtggcaagt acatgggcga gctggtgcgg   1080

cttgtgctgc tcaggctcgt ggacgaaaac ctgctcttcc acggggaggc ctccgagcag   1140

ctgcgcacac gcggagcctt cgagacgcgc ttcgtgtcgc aggtggagag cgacacgggc   1200

gaccgcaagc agatctacaa catcctgagc acgctggggc tgcgaccctc gaccaccgac   1260

tgcgacatcg tgcgccgcgc ctgcgagagc gtgtctacgc gcgctgcgca catgtgctcg   1320

gcggggctgg cgggcgtcat caaccgcatg cgcgagagcc gcagcgagga cgtaatgcgc   1380

atcactgtgg gcgtggatgg ctccgtgtac aagctgcacc ccagcttcaa ggagcggttc   1440

catgccagcg tgcgcaggct gacgcccagc tgcgagatca ccttcatcga gtcggaggag   1500

ggcagtggcc ggggcgcggc cctggtctcg gcggtggcct gtaagaaggc ctgtatgctg   1560

ggccagtgag agcagtggcc gcaagcgcag ggaggatgcc acagccccac agcacccagg   1620

ctccatgggg aagtgctccc cacacgtgct cgcagcctgg cggggcagga ggcctggcct   1680

tgtcaggacc caggccgcct gccataccgc tggggaacag agcgggcctc ttccctcagt   1740

ttttcggtgg gacagcccca gggccctaac gggggtgcgg caggagcagg aacagagact   1800

ctggaagccc cccacctttc tcgctggaat caatttccca gaagggagtt gctcactcag   1860

gactttgatg catttccaca ctgtcagagc tgttggcctc gcctgggccc aggctctggg   1920

aaggggtgcc ctctggatcc tgctgtggcc tcacttccct gggaactcat cctgtgtggg   1980

gaggcagctc caacagcttg accagaccta gacctgggcc aaaagggcag ccaggggctg   2040

ctcatcaccc agtcctggcc attttcttgc ctgaggctca agaggcccag ggagcaatgg   2100

gagggggctc catggaggag gtgtcccaag ctttgaatac ccccagagac cttttctctc   2160

ccataccatc actgagtggc ttgtgattct gggatggacc ctcgcagcag gtgcaagaga   2220

cagagccccc aagcctctgc cccaaggggc ccacaaaggg gagaagggcc agccctacat   2280

cttcagctcc catagcgctg gctcaggaag aaaccccaag cagcattcag cacaccccaa   2340

gggacaaccc catcatatga catgccaccc tctccatgcc caacctaaga ttgtgtgggt   2400

tttttaatta aaaatgttaa aagttttaaa catgaaaaaa aa                      2442


<210>  1992
<211>  466
<212>  PRT
<213>  Homosapiens

<400>  1992

Met Ala Met Asp Val Thr Arg Ser Gln Ala Gln Thr Ala Leu Thr Leu 
1               5                   10                  15      


Val Glu Gln Ile Leu Ala Glu Phe Gln Leu Gln Glu Glu Asp Leu Lys 
            20                  25                  30          


Lys Val Met Arg Arg Met Gln Lys Glu Met Asp Arg Gly Leu Arg Leu 
        35                  40                  45              


Glu Thr His Glu Glu Ala Ser Val Lys Met Leu Pro Thr Tyr Val Arg 
    50                  55                  60                  


Ser Thr Pro Glu Gly Ser Glu Val Gly Asp Phe Leu Ser Leu Asp Leu 
65                  70                  75                  80  


Gly Gly Thr Asn Phe Arg Val Met Leu Val Lys Val Gly Glu Gly Glu 
                85                  90                  95      


Glu Gly Gln Trp Ser Val Lys Thr Lys His Gln Met Tyr Ser Ile Pro 
            100                 105                 110         


Glu Asp Ala Met Thr Gly Thr Ala Glu Met Leu Phe Asp Tyr Ile Ser 
        115                 120                 125             


Glu Cys Ile Ser Asp Phe Leu Asp Lys His Gln Met Lys His Lys Lys 
    130                 135                 140                 


Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Val Arg His Glu Asp Ile 
145                 150                 155                 160 


Asp Lys Gly Ile Leu Leu Asn Trp Thr Lys Gly Phe Lys Ala Ser Gly 
                165                 170                 175     


Ala Glu Gly Asn Asn Val Val Gly Leu Leu Arg Asp Ala Ile Lys Arg 
            180                 185                 190         


Arg Gly Asp Phe Glu Met Asp Val Val Ala Met Val Asn Asp Thr Val 
        195                 200                 205             


Ala Thr Met Ile Ser Cys Tyr Tyr Glu Asp His Gln Cys Glu Val Gly 
    210                 215                 220                 


Met Ile Val Gly Thr Gly Cys Asn Ala Cys Tyr Met Glu Glu Met Gln 
225                 230                 235                 240 


Asn Val Glu Leu Val Glu Gly Asp Glu Gly Arg Met Cys Val Asn Thr 
                245                 250                 255     


Glu Trp Gly Ala Phe Gly Asp Ser Gly Glu Leu Asp Glu Phe Leu Leu 
            260                 265                 270         


Glu Tyr Asp Arg Leu Val Asp Glu Ser Ser Ala Asn Pro Gly Gln Gln 
        275                 280                 285             


Leu Tyr Glu Lys Leu Ile Gly Gly Lys Tyr Met Gly Glu Leu Val Arg 
    290                 295                 300                 


Leu Val Leu Leu Arg Leu Val Asp Glu Asn Leu Leu Phe His Gly Glu 
305                 310                 315                 320 


Ala Ser Glu Gln Leu Arg Thr Arg Gly Ala Phe Glu Thr Arg Phe Val 
                325                 330                 335     


Ser Gln Val Glu Ser Asp Thr Gly Asp Arg Lys Gln Ile Tyr Asn Ile 
            340                 345                 350         


Leu Ser Thr Leu Gly Leu Arg Pro Ser Thr Thr Asp Cys Asp Ile Val 
        355                 360                 365             


Arg Arg Ala Cys Glu Ser Val Ser Thr Arg Ala Ala His Met Cys Ser 
    370                 375                 380                 


Ala Gly Leu Ala Gly Val Ile Asn Arg Met Arg Glu Ser Arg Ser Glu 
385                 390                 395                 400 


Asp Val Met Arg Ile Thr Val Gly Val Asp Gly Ser Val Tyr Lys Leu 
                405                 410                 415     


His Pro Ser Phe Lys Glu Arg Phe His Ala Ser Val Arg Arg Leu Thr 
            420                 425                 430         


Pro Ser Cys Glu Ile Thr Phe Ile Glu Ser Glu Glu Gly Ser Gly Arg 
        435                 440                 445             


Gly Ala Ala Leu Val Ser Ala Val Ala Cys Lys Lys Ala Cys Met Leu 
    450                 455                 460                 


Gly Gln 
465     


<210>  1993
<211>  2566
<212>  DNA
<213>  Homosapiens

<400>  1993
cctttcagtg cagaagccct gggctgccag cctcaggcag ctctccatcc aagcagccgt     60

tgctgccaca ggcgggcctt acgctccaag gctacagcat gtgctaggcc tcagcaggca    120

ggagcatctc tgcctcccaa agcatctacc tcttagcccc tcggagagat ggcgatggat    180

gtcacaagga gccaggccca gacagccttg actctgccag actctcctct gaactcgggc    240

ctcacatggc caactgctac ttggaacaaa tcgccccttg gctggcagat gtgttaacat    300

gcccagacca agatcccaac tcccacaacc caactcccag gtagagcaga tcctggcaga    360

gttccagctg caggaggagg acctgaagaa ggtgatgaga cggatgcaga aggagatgga    420

ccgcggcctg aggctggaga cccatgaaga ggccagtgtg aagatgctgc ccacctacgt    480

gcgctccacc ccagaaggct cagaagtcgg ggacttcctc tccctggacc tgggtggcac    540

taacttcagg gtgatgctgg tgaaggtggg agaaggtgag gaggggcagt ggagcgtgaa    600

gaccaaacac cagatgtact ccatccccga ggacgccatg accggcactg ctgagatgct    660

cttcgactac atctctgagt gcatctccga cttcctggac aagcatcaga tgaaacacaa    720

gaagctgccc ctgggcttca ccttctcctt tcctgtgagg cacgaagaca tcgataaggg    780

catccttctc aactggacca agggcttcaa ggcctcagga gcagaaggga acaatgtcgt    840

ggggcttctg cgagacgcta tcaaacggag aggggacttt gaaatggatg tggtggcaat    900

ggtgaatgac acggtggcca cgatgatctc ctgctactac gaagaccatc agtgcgaggt    960

cggcatgatc gtgggcacgg gctgcaatgc ctgctacatg gaggagatgc agaatgtgga   1020

gctggtggag ggggacgagg gccgcatgtg cgtcaatacc gagtggggcg ccttcgggga   1080

ctccggcgag ctggacgagt tcctgctgga gtatgaccgc ctggtggacg agagctctgc   1140

aaaccccggt cagcagctgt atgagaagct cataggtggc aagtacatgg gcgagctggt   1200

gcggcttgtg ctgctcaggc tcgtggacga aaacctgctc ttccacgggg aggcctccga   1260

gcagctgcgc acacgcggag ccttcgagac gcgcttcgtg tcgcaggtgg agagcgacac   1320

gggcgaccgc aagcagatct acaacatcct gagcacgctg gggctgcgac cctcgaccac   1380

cgactgcgac atcgtgcgcc gcgcctgcga gagcgtgtct acgcgcgctg cgcacatgtg   1440

ctcggcgggg ctggcgggcg tcatcaaccg catgcgcgag agccgcagcg aggacgtaat   1500

gcgcatcact gtgggcgtgg atggctccgt gtacaagctg caccccagct tcaaggagcg   1560

gttccatgcc agcgtgcgca ggctgacgcc cagctgcgag atcaccttca tcgagtcgga   1620

ggagggcagt ggccggggcg cggccctggt ctcggcggtg gcctgtaaga aggcctgtat   1680

gctgggccag tgagagcagt ggccgcaagc gcagggagga tgccacagcc ccacagcacc   1740

caggctccat ggggaagtgc tccccacacg tgctcgcagc ctggcggggc aggaggcctg   1800

gccttgtcag gacccaggcc gcctgccata ccgctgggga acagagcggg cctcttccct   1860

cagtttttcg gtgggacagc cccagggccc taacgggggt gcggcaggag caggaacaga   1920

gactctggaa gccccccacc tttctcgctg gaatcaattt cccagaaggg agttgctcac   1980

tcaggacttt gatgcatttc cacactgtca gagctgttgg cctcgcctgg gcccaggctc   2040

tgggaagggg tgccctctgg atcctgctgt ggcctcactt ccctgggaac tcatcctgtg   2100

tggggaggca gctccaacag cttgaccaga cctagacctg ggccaaaagg gcagccaggg   2160

gctgctcatc acccagtcct ggccattttc ttgcctgagg ctcaagaggc ccagggagca   2220

atgggagggg gctccatgga ggaggtgtcc caagctttga atacccccag agaccttttc   2280

tctcccatac catcactgag tggcttgtga ttctgggatg gaccctcgca gcaggtgcaa   2340

gagacagagc ccccaagcct ctgccccaag gggcccacaa aggggagaag ggccagccct   2400

acatcttcag ctcccatagc gctggctcag gaagaaaccc caagcagcat tcagcacacc   2460

ccaagggaca accccatcat atgacatgcc accctctcca tgcccaacct aagattgtgt   2520

gggtttttta attaaaaatg ttaaaagttt taaacatgaa aaaaaa                  2566


<210>  1994
<211>  464
<212>  PRT
<213>  Homosapiens

<400>  1994

Met Pro Arg Pro Arg Ser Gln Leu Pro Gln Pro Asn Ser Gln Val Glu 
1               5                   10                  15      


Gln Ile Leu Ala Glu Phe Gln Leu Gln Glu Glu Asp Leu Lys Lys Val 
            20                  25                  30          


Met Arg Arg Met Gln Lys Glu Met Asp Arg Gly Leu Arg Leu Glu Thr 
        35                  40                  45              


His Glu Glu Ala Ser Val Lys Met Leu Pro Thr Tyr Val Arg Ser Thr 
    50                  55                  60                  


Pro Glu Gly Ser Glu Val Gly Asp Phe Leu Ser Leu Asp Leu Gly Gly 
65                  70                  75                  80  


Thr Asn Phe Arg Val Met Leu Val Lys Val Gly Glu Gly Glu Glu Gly 
                85                  90                  95      


Gln Trp Ser Val Lys Thr Lys His Gln Met Tyr Ser Ile Pro Glu Asp 
            100                 105                 110         


Ala Met Thr Gly Thr Ala Glu Met Leu Phe Asp Tyr Ile Ser Glu Cys 
        115                 120                 125             


Ile Ser Asp Phe Leu Asp Lys His Gln Met Lys His Lys Lys Leu Pro 
    130                 135                 140                 


Leu Gly Phe Thr Phe Ser Phe Pro Val Arg His Glu Asp Ile Asp Lys 
145                 150                 155                 160 


Gly Ile Leu Leu Asn Trp Thr Lys Gly Phe Lys Ala Ser Gly Ala Glu 
                165                 170                 175     


Gly Asn Asn Val Val Gly Leu Leu Arg Asp Ala Ile Lys Arg Arg Gly 
            180                 185                 190         


Asp Phe Glu Met Asp Val Val Ala Met Val Asn Asp Thr Val Ala Thr 
        195                 200                 205             


Met Ile Ser Cys Tyr Tyr Glu Asp His Gln Cys Glu Val Gly Met Ile 
    210                 215                 220                 


Val Gly Thr Gly Cys Asn Ala Cys Tyr Met Glu Glu Met Gln Asn Val 
225                 230                 235                 240 


Glu Leu Val Glu Gly Asp Glu Gly Arg Met Cys Val Asn Thr Glu Trp 
                245                 250                 255     


Gly Ala Phe Gly Asp Ser Gly Glu Leu Asp Glu Phe Leu Leu Glu Tyr 
            260                 265                 270         


Asp Arg Leu Val Asp Glu Ser Ser Ala Asn Pro Gly Gln Gln Leu Tyr 
        275                 280                 285             


Glu Lys Leu Ile Gly Gly Lys Tyr Met Gly Glu Leu Val Arg Leu Val 
    290                 295                 300                 


Leu Leu Arg Leu Val Asp Glu Asn Leu Leu Phe His Gly Glu Ala Ser 
305                 310                 315                 320 


Glu Gln Leu Arg Thr Arg Gly Ala Phe Glu Thr Arg Phe Val Ser Gln 
                325                 330                 335     


Val Glu Ser Asp Thr Gly Asp Arg Lys Gln Ile Tyr Asn Ile Leu Ser 
            340                 345                 350         


Thr Leu Gly Leu Arg Pro Ser Thr Thr Asp Cys Asp Ile Val Arg Arg 
        355                 360                 365             


Ala Cys Glu Ser Val Ser Thr Arg Ala Ala His Met Cys Ser Ala Gly 
    370                 375                 380                 


Leu Ala Gly Val Ile Asn Arg Met Arg Glu Ser Arg Ser Glu Asp Val 
385                 390                 395                 400 


Met Arg Ile Thr Val Gly Val Asp Gly Ser Val Tyr Lys Leu His Pro 
                405                 410                 415     


Ser Phe Lys Glu Arg Phe His Ala Ser Val Arg Arg Leu Thr Pro Ser 
            420                 425                 430         


Cys Glu Ile Thr Phe Ile Glu Ser Glu Glu Gly Ser Gly Arg Gly Ala 
        435                 440                 445             


Ala Leu Val Ser Ala Val Ala Cys Lys Lys Ala Cys Met Leu Gly Gln 
    450                 455                 460                 


<210>  1995
<211>  2783
<212>  DNA
<213>  Homosapiens

<400>  1995
gattgcgagc caggaggagg aagccggcgg tggccccgtc agcagccggc tgctgagagg     60

ccggtaggcg gcggcggtcc cgaggggcgg cggccgcgct gctccctgag aacgggtccc    120

gcagctgggc aggcgggcgg cctgagggcg cggagccatg aagctgtaca gcctcagcgt    180

cctctacaaa ggcgaggcca aggtggtgct gctcaaagcc gcatacgatg tgtcttcctt    240

cagctttttc cagagatcca gcgttcagga attcatgacc ttcacgagtc aactgattgt    300

ggagcgctca tcgaaaggca ctagagcttc tgtcaaagaa caagactatc tgtgccacgt    360

ctacgtccgg aatgatagtc ttgcaggtgt ggtcattgct gacaatgaat acccatcccg    420

ggtggccttt accttgctgg agaaggtact agatgaattc tccaagcaag tcgacaggat    480

agactggcca gtaggatccc ctgctacaat ccattaccca gccctggatg gtcacctcag    540

tagataccag aacccacgag aagctgatcc catgactaaa gtgcaggccg aactagatga    600

gaccaaaatc attctgcaca acaccatgga gtctctgtta gagcgaggtg agaagctaga    660

tgacttggtg tccaaatccg aggtgctggg aacacagtct aaagccttct ataaaactgc    720

ccggaaacaa aactcatgct gtgccatcat gtgatgcagc ctgccagagg cccaatgctg    780

gaatggcacc atcattcaca tcagaactgc agcccctgga aaagaagaga cagccataga    840

cgaggagcca gagtgggggc agactggcca tttttatttt gaagttcctg cgagaaatgg    900

atggtggaag ggtggcgaat gttcaaattc atatgtgtgg tagtgattct tggaaagaat    960

ttgaggtccc caaaggtgta tttttgggca aatgaaacca taaactccga ctggcttctg   1020

tagatgccaa agggctcttt ttcagctaac cctgggaagg ctctgtggga gggaggtcgg   1080

agccagctgt ttctcgatct ttggtatatc tttggatctt atttgtacat taatgatatt   1140

aacactccag tggggggtgg ggagtccctg atgctagggc tggggtgggt ggagtttgaa   1200

gactcttggg aaagcctctc ctggggccac tgttgggggt gggagtgagc ccaccacaga   1260

ggccacaggc aggcccccac ttcaggccca aggcctgggg cggggggaac agtcactggg   1320

tctcagattc tgagactgtt gtttagctta cctttctgct aggattggct tcccgcagag   1380

ggcagggccc atcctaagca gcttccaagt cccacaaagg tggcttgtgg gaggatttgg   1440

aaggagctgc attgtgggcg gggagtgtgt gggttgggtt cgtaccagca agtagactag   1500

gaactgagcc caggaaaggg ggatgttttc ctggtgtttg gatggtcagc tgggagtgtc   1560

catcatcagg ggaagatcaa acacaggtgc actcagctgc ccagggcctc tgggacactt   1620

gccttgactt gcaacttgcc ttgaacatca cgatcaaagc agcaggtgct gtggtctctc   1680

aaaattgatt tttatttgac tctgtggctc taagactgcc ttgaaccgcc tgaggcctat   1740

gcatctgaac aagtgggtct ctcccttgag caccaggagt gggtgccagc cggccccgag   1800

gattcccagc accccaccta tggtcttgcc agcataggct tgctagttcc ttcttggtca   1860

gaggtagctg cagagggggg aggccaaggg tttggtctaa gctgtgccct gccacctggc   1920

aggaggccca ctcactgccc aagtcatggc aacaggctgg agcagcccag gagatgggcc   1980

taaaatgttc tggatccctt gggtcctagt gttatgttcc agtctgccca cctgtgctca   2040

ggatgcagcc ctgggatcca gcacccatgg aagcttctgc tgggatggtg tcacctatgg   2100

gttttgaacc agtgtggtat ggtccttggg agctctgctc tgagcttgcc acactgctga   2160

gagcacccac tgtcctgacc agagtctcag tggtcctgac ccccaatgtg ggcaggggct   2220

gggcaggagg gtggggtctg ctgtgggttc agaggactcc acctcctggc tggtttacct   2280

gctgctgccc attttctctg ggtactgctg gccagaggac tttagcctac ccctgaagag   2340

cctgtccatg tcattttcct actgccatag ataccctaag cccagggccc cttgaggccc   2400

agactcagcc tgcccactgg tgccggagac ggagtggagt gggcctggat ccgagggatg   2460

ctacctctcc ctttcccact tgaggaccct ggggagagat gggggcgggg aaaatggagg   2520

tatgaatttg gggtaagagg aagtgagatc tccgcttgca ggtcagcccc tgccttgcag   2580

ggcgggctgg cttgactcag gccctgtgag atagagggcc cagcccagcc ccacccacag   2640

atcccctgct cctgttgtgt tctgttgtaa atcatttggc gagactgtat tttagtaact   2700

gctgcctaac ttccctgtgt tctatttgag aggcgcctgt ctggataaag ttgtcttgaa   2760

atttcaaaaa aaaaaaaaaa aaa                                           2783


<210>  1996
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  1996

Met Lys Leu Tyr Ser Leu Ser Val Leu Tyr Lys Gly Glu Ala Lys Val 
1               5                   10                  15      


Val Leu Leu Lys Ala Ala Tyr Asp Val Ser Ser Phe Ser Phe Phe Gln 
            20                  25                  30          


Arg Ser Ser Val Gln Glu Phe Met Thr Phe Thr Ser Gln Leu Ile Val 
        35                  40                  45              


Glu Arg Ser Ser Lys Gly Thr Arg Ala Ser Val Lys Glu Gln Asp Tyr 
    50                  55                  60                  


Leu Cys His Val Tyr Val Arg Asn Asp Ser Leu Ala Gly Val Val Ile 
65                  70                  75                  80  


Ala Asp Asn Glu Tyr Pro Ser Arg Val Ala Phe Thr Leu Leu Glu Lys 
                85                  90                  95      


Val Leu Asp Glu Phe Ser Lys Gln Val Asp Arg Ile Asp Trp Pro Val 
            100                 105                 110         


Gly Ser Pro Ala Thr Ile His Tyr Pro Ala Leu Asp Gly His Leu Ser 
        115                 120                 125             


Arg Tyr Gln Asn Pro Arg Glu Ala Asp Pro Met Thr Lys Val Gln Ala 
    130                 135                 140                 


Glu Leu Asp Glu Thr Lys Ile Ile Leu His Asn Thr Met Glu Ser Leu 
145                 150                 155                 160 


Leu Glu Arg Gly Glu Lys Leu Asp Asp Leu Val Ser Lys Ser Glu Val 
                165                 170                 175     


Leu Gly Thr Gln Ser Lys Ala Phe Tyr Lys Thr Ala Arg Lys Gln Asn 
            180                 185                 190         


Ser Cys Cys Ala Ile Met 
        195             


<210>  1997
<211>  2438
<212>  DNA
<213>  Homosapiens

<400>  1997
gcggcgcgct cctggcgagg acggagcgag cagatctcgc gtgcgctcgc cgcccggcgc     60

agcccagccc ggcccccgcc tggcgccgcg agccgaggtg tctcccgcgc ccgcgcccgt    120

gtcgccgccg tgcccgcgag cgggagccgg agtcgccgcc gcccgagcgc agccgagcgc    180

acgccgagcc cgtccgccgc cgccatggcc accacggtga cctgcacccg cttcaccgac    240

gagtaccagc tctacgagga tattggcaag ggggctttct ctgtggtccg acgctgtgtc    300

aagctctgca ccggccatga gtatgcagcc aagatcatca acaccaagaa gctgtcagcc    360

agagatcacc agaagctgga gagagaggct cggatctgcc gccttctgaa gcattccaac    420

atcgtgcgtc tccacgacag catctccgag gagggcttcc actacctggt cttcgatctg    480

gtcactggtg gggagctctt tgaagacatt gtggcgagag agtactacag cgaggctgat    540

gccagtcact gtatccagca gatcctggag gccgttctcc attgtcacca aatgggggtc    600

gtccacagag acctcaagcc ggagaacctg cttctggcca gcaagtgcaa aggggctgca    660

gtgaagctgg cagacttcgg cctagctatc gaggtgcagg gggaccagca ggcatggttt    720

ggtttcgctg gcacaccagg ctacctgtcc cctgaggtcc ttcgcaaaga ggcgtatggc    780

aagcctgtgg acatctgggc atgtggggtg atcctgtaca tcctgctcgt gggctaccca    840

cccttctggg acgaggacca gcacaagctg taccagcaga tcaaggctgg tgcctatgac    900

ttcccgtccc ctgagtggga caccgtcact cctgaagcca aaaacctcat caaccagatg    960

ctgaccatca accctgccaa gcgcatcaca gcccatgagg ccctgaagca cccgtgggtc   1020

tgccaacgct ccacggtagc atccatgatg cacagacagg agactgtgga gtgtctgaaa   1080

aagttcaatg ccaggagaaa gctcaaggga gccatcctca ccaccatgct ggccacacgg   1140

aatttctcag tgggcagaca gaccaccgct ccggccacaa tgtccaccgc ggcctccggc   1200

accaccatgg ggctggtgga acaagccaag agtttactca acaagaaagc agatggagtc   1260

aagccccaga cgaatagcac caaaaacagt gcagccgcca ccagccccaa agggacgctt   1320

cctcctgccg ccctggagcc tcaaaccacc gtcatccata acccagtgga cgggattaag   1380

gagtcttctg acagtgccaa taccaccata gaggatgaag acgctaaagc ccccagggtc   1440

cccgacatcc tgagctcagt gaggaggggc tcgggagccc cagaagccga ggggcccctg   1500

ccctgcccat ctccggctcc ctttagcccc ctgccagccc catcccccag gatctctgac   1560

atcctgaact ctgtgagaag gggttcagga accccagaag ccgagggccc cctctcagcg   1620

gggcccccgc cctgcctgtc tccggctctc ctaggccccc tgtcctcccc gtcccccagg   1680

atctctgaca tcctgaactc tgtgaggagg ggctcaggga ccccagaagc cgagggcccc   1740

tcgccagtgg ggcccccgcc ctgcccatct ccgactatcc ctggccccct gcccacccca   1800

tcccggaagc aggagatcat taagaccacg gagcagctca tcgaggccgt caacaacggt   1860

gactttgagg cctacgcgaa aatctgtgac ccagggctga cctcgtttga gcctgaagca   1920

ctgggcaacc tggttgaagg gatggacttc cacagattct acttcgagaa cctgctggcc   1980

aagaacagca agccgatcca cacgaccatc ctgaacccac acgtgcacgt cattggagag   2040

gatgccgcct gcatcgctta catccggctc acgcagtaca ttgacgggca gggccggccc   2100

cgcaccagcc agtctgagga gacccgcgtg tggcaccgcc gcgacggcaa gtggcagaac   2160

gtgcacttcc actgctcggg cgcgcctgtg gccccgctgc agtgaagagc tgcgccctgg   2220

tttcgccgga cagagttggt gtttggagcc cgactgccct cgggcacacg gcctgcctgt   2280

cgcatgtttg tgtctgcctc gttccctccc ctggtgcctg tgtctgcaga aaaacaagac   2340

cagatgtgat ttgttaaaaa aaaacaaaaa aaaaaaaaaa aaaaacaaga tgacgacgac   2400

aaccacaaaa aaaattgaca tcagatgaaa tgaaaaaa                           2438


<210>  1998
<211>  666
<212>  PRT
<213>  Homosapiens

<400>  1998

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr 
305                 310                 315                 320 


Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly 
                325                 330                 335     


Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
            340                 345                 350         


Lys Pro Gln Thr Asn Ser Thr Lys Asn Ser Ala Ala Ala Thr Ser Pro 
        355                 360                 365             


Lys Gly Thr Leu Pro Pro Ala Ala Leu Glu Pro Gln Thr Thr Val Ile 
    370                 375                 380                 


His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Ala Asn Thr 
385                 390                 395                 400 


Thr Ile Glu Asp Glu Asp Ala Lys Ala Pro Arg Val Pro Asp Ile Leu 
                405                 410                 415     


Ser Ser Val Arg Arg Gly Ser Gly Ala Pro Glu Ala Glu Gly Pro Leu 
            420                 425                 430         


Pro Cys Pro Ser Pro Ala Pro Phe Ser Pro Leu Pro Ala Pro Ser Pro 
        435                 440                 445             


Arg Ile Ser Asp Ile Leu Asn Ser Val Arg Arg Gly Ser Gly Thr Pro 
    450                 455                 460                 


Glu Ala Glu Gly Pro Leu Ser Ala Gly Pro Pro Pro Cys Leu Ser Pro 
465                 470                 475                 480 


Ala Leu Leu Gly Pro Leu Ser Ser Pro Ser Pro Arg Ile Ser Asp Ile 
                485                 490                 495     


Leu Asn Ser Val Arg Arg Gly Ser Gly Thr Pro Glu Ala Glu Gly Pro 
            500                 505                 510         


Ser Pro Val Gly Pro Pro Pro Cys Pro Ser Pro Thr Ile Pro Gly Pro 
        515                 520                 525             


Leu Pro Thr Pro Ser Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln 
    530                 535                 540                 


Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile 
545                 550                 555                 560 


Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu 
                565                 570                 575     


Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala 
            580                 585                 590         


Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn Pro His Val His 
        595                 600                 605             


Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln 
    610                 615                 620                 


Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr 
625                 630                 635                 640 


Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His 
                645                 650                 655     


Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
            660                 665     


<210>  1999
<211>  2066
<212>  DNA
<213>  Homosapiens

<400>  1999
gcggcgcgct cctggcgagg acggagcgag cagatctcgc gtgcgctcgc cgcccggcgc     60

agcccagccc ggcccccgcc tggcgccgcg agccgaggtg tctcccgcgc ccgcgcccgt    120

gtcgccgccg tgcccgcgag cgggagccgg agtcgccgcc gcccgagcgc agccgagcgc    180

acgccgagcc cgtccgccgc cgccatggcc accacggtga cctgcacccg cttcaccgac    240

gagtaccagc tctacgagga tattggcaag ggggctttct ctgtggtccg acgctgtgtc    300

aagctctgca ccggccatga gtatgcagcc aagatcatca acaccaagaa gctgtcagcc    360

agagatcacc agaagctgga gagagaggct cggatctgcc gccttctgaa gcattccaac    420

atcgtgcgtc tccacgacag catctccgag gagggcttcc actacctggt cttcgatctg    480

gtcactggtg gggagctctt tgaagacatt gtggcgagag agtactacag cgaggctgat    540

gccagtcact gtatccagca gatcctggag gccgttctcc attgtcacca aatgggggtc    600

gtccacagag acctcaagcc ggagaacctg cttctggcca gcaagtgcaa aggggctgca    660

gtgaagctgg cagacttcgg cctagctatc gaggtgcagg gggaccagca ggcatggttt    720

ggtttcgctg gcacaccagg ctacctgtcc cctgaggtcc ttcgcaaaga ggcgtatggc    780

aagcctgtgg acatctgggc atgtggggtg atcctgtaca tcctgctcgt gggctaccca    840

cccttctggg acgaggacca gcacaagctg taccagcaga tcaaggctgg tgcctatgac    900

ttcccgtccc ctgagtggga caccgtcact cctgaagcca aaaacctcat caaccagatg    960

ctgaccatca accctgccaa gcgcatcaca gcccatgagg ccctgaagca cccgtgggtc   1020

tgccaacgct ccacggtagc atccatgatg cacagacagg agactgtgga gtgtctgaaa   1080

aagttcaatg ccaggagaaa gctcaaggga gccatcctca ccaccatgct ggccacacgg   1140

aatttctcag tgggcagaca gaccaccgct ccggccacaa tgtccaccgc ggcctccggc   1200

accaccatgg ggctggtgga acaagccaag agtttactca acaagaaagc agatggagtc   1260

aagccccaga cgaatagcac caaaaacagt gcagccgcca ccagccccaa agggacgctt   1320

cctcctgccg ccctggagcc tcaaaccacc gtcatccata acccagtgga cgggattaag   1380

gagtcttctg acagtgccaa taccaccata gaggatgaag acgctaaagc ccggaagcag   1440

gagatcatta agaccacgga gcagctcatc gaggccgtca acaacggtga ctttgaggcc   1500

tacgcgaaaa tctgtgaccc agggctgacc tcgtttgagc ctgaagcact gggcaacctg   1560

gttgaaggga tggacttcca cagattctac ttcgagaacc tgctggccaa gaacagcaag   1620

ccgatccaca cgaccatcct gaacccacac gtgcacgtca ttggagagga tgccgcctgc   1680

atcgcttaca tccggctcac gcagtacatt gacgggcagg gccggccccg caccagccag   1740

tctgaggaga cccgcgtgtg gcaccgccgc gacggcaagt ggcagaacgt gcacttccac   1800

tgctcgggcg cgcctgtggc cccgctgcag tgaagagctg cgccctggtt tcgccggaca   1860

gagttggtgt ttggagcccg actgccctcg ggcacacggc ctgcctgtcg catgtttgtg   1920

tctgcctcgt tccctcccct ggtgcctgtg tctgcagaaa aacaagacca gatgtgattt   1980

gttaaaaaaa aacaaaaaaa aaaaaaaaaa aaacaagatg acgacgacaa ccacaaaaaa   2040

aattgacatc agatgaaatg aaaaaa                                        2066


<210>  2000
<211>  542
<212>  PRT
<213>  Homosapiens

<400>  2000

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr 
305                 310                 315                 320 


Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly 
                325                 330                 335     


Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
            340                 345                 350         


Lys Pro Gln Thr Asn Ser Thr Lys Asn Ser Ala Ala Ala Thr Ser Pro 
        355                 360                 365             


Lys Gly Thr Leu Pro Pro Ala Ala Leu Glu Pro Gln Thr Thr Val Ile 
    370                 375                 380                 


His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Ala Asn Thr 
385                 390                 395                 400 


Thr Ile Glu Asp Glu Asp Ala Lys Ala Arg Lys Gln Glu Ile Ile Lys 
                405                 410                 415     


Thr Thr Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu Ala 
            420                 425                 430         


Tyr Ala Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala 
        435                 440                 445             


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
    450                 455                 460                 


Asn Leu Leu Ala Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn 
465                 470                 475                 480 


Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile 
                485                 490                 495     


Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln 
            500                 505                 510         


Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
        515                 520                 525             


Val His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
    530                 535                 540         


<210>  2001
<211>  1994
<212>  DNA
<213>  Homosapiens

<400>  2001
gcggcgcgct cctggcgagg acggagcgag cagatctcgc gtgcgctcgc cgcccggcgc     60

agcccagccc ggcccccgcc tggcgccgcg agccgaggtg tctcccgcgc ccgcgcccgt    120

gtcgccgccg tgcccgcgag cgggagccgg agtcgccgcc gcccgagcgc agccgagcgc    180

acgccgagcc cgtccgccgc cgccatggcc accacggtga cctgcacccg cttcaccgac    240

gagtaccagc tctacgagga tattggcaag ggggctttct ctgtggtccg acgctgtgtc    300

aagctctgca ccggccatga gtatgcagcc aagatcatca acaccaagaa gctgtcagcc    360

agagatcacc agaagctgga gagagaggct cggatctgcc gccttctgaa gcattccaac    420

atcgtgcgtc tccacgacag catctccgag gagggcttcc actacctggt cttcgatctg    480

gtcactggtg gggagctctt tgaagacatt gtggcgagag agtactacag cgaggctgat    540

gccagtcact gtatccagca gatcctggag gccgttctcc attgtcacca aatgggggtc    600

gtccacagag acctcaagcc ggagaacctg cttctggcca gcaagtgcaa aggggctgca    660

gtgaagctgg cagacttcgg cctagctatc gaggtgcagg gggaccagca ggcatggttt    720

ggtttcgctg gcacaccagg ctacctgtcc cctgaggtcc ttcgcaaaga ggcgtatggc    780

aagcctgtgg acatctgggc atgtggggtg atcctgtaca tcctgctcgt gggctaccca    840

cccttctggg acgaggacca gcacaagctg taccagcaga tcaaggctgg tgcctatgac    900

ttcccgtccc ctgagtggga caccgtcact cctgaagcca aaaacctcat caaccagatg    960

ctgaccatca accctgccaa gcgcatcaca gcccatgagg ccctgaagca cccgtgggtc   1020

tgccaacgct ccacggtagc atccatgatg cacagacagg agactgtgga gtgtctgaaa   1080

aagttcaatg ccaggagaaa gctcaaggga gccatcctca ccaccatgct ggccacacgg   1140

aatttctcag cagccaagag tttactcaac aagaaagcag atggagtcaa gccccagacg   1200

aatagcacca aaaacagtgc agccgccacc agccccaaag ggacgcttcc tcctgccgcc   1260

ctggagcctc aaaccaccgt catccataac ccagtggacg ggattaagga gtcttctgac   1320

agtgccaata ccaccataga ggatgaagac gctaaagccc ggaagcagga gatcattaag   1380

accacggagc agctcatcga ggccgtcaac aacggtgact ttgaggccta cgcgaaaatc   1440

tgtgacccag ggctgacctc gtttgagcct gaagcactgg gcaacctggt tgaagggatg   1500

gacttccaca gattctactt cgagaacctg ctggccaaga acagcaagcc gatccacacg   1560

accatcctga acccacacgt gcacgtcatt ggagaggatg ccgcctgcat cgcttacatc   1620

cggctcacgc agtacattga cgggcagggc cggccccgca ccagccagtc tgaggagacc   1680

cgcgtgtggc accgccgcga cggcaagtgg cagaacgtgc acttccactg ctcgggcgcg   1740

cctgtggccc cgctgcagtg aagagctgcg ccctggtttc gccggacaga gttggtgttt   1800

ggagcccgac tgccctcggg cacacggcct gcctgtcgca tgtttgtgtc tgcctcgttc   1860

cctcccctgg tgcctgtgtc tgcagaaaaa caagaccaga tgtgatttgt taaaaaaaaa   1920

caaaaaaaaa aaaaaaaaaa acaagatgac gacgacaacc acaaaaaaaa ttgacatcag   1980

atgaaatgaa aaaa                                                     1994


<210>  2002
<211>  518
<212>  PRT
<213>  Homosapiens

<400>  2002

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ala Asp Gly Val Lys Pro Gln Thr Asn Ser Thr Lys 
                325                 330                 335     


Asn Ser Ala Ala Ala Thr Ser Pro Lys Gly Thr Leu Pro Pro Ala Ala 
            340                 345                 350         


Leu Glu Pro Gln Thr Thr Val Ile His Asn Pro Val Asp Gly Ile Lys 
        355                 360                 365             


Glu Ser Ser Asp Ser Ala Asn Thr Thr Ile Glu Asp Glu Asp Ala Lys 
    370                 375                 380                 


Ala Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln Leu Ile Glu Ala 
385                 390                 395                 400 


Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp Pro Gly 
                405                 410                 415     


Leu Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met 
            420                 425                 430         


Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn Ser Lys 
        435                 440                 445             


Pro Ile His Thr Thr Ile Leu Asn Pro His Val His Val Ile Gly Glu 
    450                 455                 460                 


Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr Ile Asp Gly 
465                 470                 475                 480 


Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr Arg Val Trp His 
                485                 490                 495     


Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser Gly Ala 
            500                 505                 510         


Pro Val Ala Pro Leu Gln 
        515             


<210>  2003
<211>  1991
<212>  DNA
<213>  Homosapiens

<400>  2003
gcggcgcgct cctggcgagg acggagcgag cagatctcgc gtgcgctcgc cgcccggcgc     60

agcccagccc ggcccccgcc tggcgccgcg agccgaggtg tctcccgcgc ccgcgcccgt    120

gtcgccgccg tgcccgcgag cgggagccgg agtcgccgcc gcccgagcgc agccgagcgc    180

acgccgagcc cgtccgccgc cgccatggcc accacggtga cctgcacccg cttcaccgac    240

gagtaccagc tctacgagga tattggcaag ggggctttct ctgtggtccg acgctgtgtc    300

aagctctgca ccggccatga gtatgcagcc aagatcatca acaccaagaa gctgtcagcc    360

agagatcacc agaagctgga gagagaggct cggatctgcc gccttctgaa gcattccaac    420

atcgtgcgtc tccacgacag catctccgag gagggcttcc actacctggt cttcgatctg    480

gtcactggtg gggagctctt tgaagacatt gtggcgagag agtactacag cgaggctgat    540

gccagtcact gtatccagca gatcctggag gccgttctcc attgtcacca aatgggggtc    600

gtccacagag acctcaagcc ggagaacctg cttctggcca gcaagtgcaa aggggctgca    660

gtgaagctgg cagacttcgg cctagctatc gaggtgcagg gggaccagca ggcatggttt    720

ggtttcgctg gcacaccagg ctacctgtcc cctgaggtcc ttcgcaaaga ggcgtatggc    780

aagcctgtgg acatctgggc atgtggggtg atcctgtaca tcctgctcgt gggctaccca    840

cccttctggg acgaggacca gcacaagctg taccagcaga tcaaggctgg tgcctatgac    900

ttcccgtccc ctgagtggga caccgtcact cctgaagcca aaaacctcat caaccagatg    960

ctgaccatca accctgccaa gcgcatcaca gcccatgagg ccctgaagca cccgtgggtc   1020

tgccaacgct ccacggtagc atccatgatg cacagacagg agactgtgga gtgtctgaaa   1080

aagttcaatg ccaggagaaa gctcaaggga gccatcctca ccaccatgct ggccacacgg   1140

aatttctcag ccaagagttt actcaacaag aaagcagatg gagtcaagcc ccagacgaat   1200

agcaccaaaa acagtgcagc cgccaccagc cccaaaggga cgcttcctcc tgccgccctg   1260

gagcctcaaa ccaccgtcat ccataaccca gtggacggga ttaaggagtc ttctgacagt   1320

gccaatacca ccatagagga tgaagacgct aaagcccgga agcaggagat cattaagacc   1380

acggagcagc tcatcgaggc cgtcaacaac ggtgactttg aggcctacgc gaaaatctgt   1440

gacccagggc tgacctcgtt tgagcctgaa gcactgggca acctggttga agggatggac   1500

ttccacagat tctacttcga gaacctgctg gccaagaaca gcaagccgat ccacacgacc   1560

atcctgaacc cacacgtgca cgtcattgga gaggatgccg cctgcatcgc ttacatccgg   1620

ctcacgcagt acattgacgg gcagggccgg ccccgcacca gccagtctga ggagacccgc   1680

gtgtggcacc gccgcgacgg caagtggcag aacgtgcact tccactgctc gggcgcgcct   1740

gtggccccgc tgcagtgaag agctgcgccc tggtttcgcc ggacagagtt ggtgtttgga   1800

gcccgactgc cctcgggcac acggcctgcc tgtcgcatgt ttgtgtctgc ctcgttccct   1860

cccctggtgc ctgtgtctgc agaaaaacaa gaccagatgt gatttgttaa aaaaaaacaa   1920

aaaaaaaaaa aaaaaaaaca agatgacgac gacaaccaca aaaaaaattg acatcagatg   1980

aaatgaaaaa a                                                        1991


<210>  2004
<211>  517
<212>  PRT
<213>  Homosapiens

<400>  2004

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Lys Ser Leu Leu 
305                 310                 315                 320 


Asn Lys Lys Ala Asp Gly Val Lys Pro Gln Thr Asn Ser Thr Lys Asn 
                325                 330                 335     


Ser Ala Ala Ala Thr Ser Pro Lys Gly Thr Leu Pro Pro Ala Ala Leu 
            340                 345                 350         


Glu Pro Gln Thr Thr Val Ile His Asn Pro Val Asp Gly Ile Lys Glu 
        355                 360                 365             


Ser Ser Asp Ser Ala Asn Thr Thr Ile Glu Asp Glu Asp Ala Lys Ala 
    370                 375                 380                 


Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln Leu Ile Glu Ala Val 
385                 390                 395                 400 


Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp Pro Gly Leu 
                405                 410                 415     


Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp 
            420                 425                 430         


Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn Ser Lys Pro 
        435                 440                 445             


Ile His Thr Thr Ile Leu Asn Pro His Val His Val Ile Gly Glu Asp 
    450                 455                 460                 


Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln 
465                 470                 475                 480 


Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr Arg Val Trp His Arg 
                485                 490                 495     


Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser Gly Ala Pro 
            500                 505                 510         


Val Ala Pro Leu Gln 
        515         


<210>  2005
<211>  1949
<212>  DNA
<213>  Homosapiens

<400>  2005
gcggcgcgct cctggcgagg acggagcgag cagatctcgc gtgcgctcgc cgcccggcgc     60

agcccagccc ggcccccgcc tggcgccgcg agccgaggtg tctcccgcgc ccgcgcccgt    120

gtcgccgccg tgcccgcgag cgggagccgg agtcgccgcc gcccgagcgc agccgagcgc    180

acgccgagcc cgtccgccgc cgccatggcc accacggtga cctgcacccg cttcaccgac    240

gagtaccagc tctacgagga tattggcaag ggggctttct ctgtggtccg acgctgtgtc    300

aagctctgca ccggccatga gtatgcagcc aagatcatca acaccaagaa gctgtcagcc    360

agagatcacc agaagctgga gagagaggct cggatctgcc gccttctgaa gcattccaac    420

atcgtgcgtc tccacgacag catctccgag gagggcttcc actacctggt cttcgatctg    480

gtcactggtg gggagctctt tgaagacatt gtggcgagag agtactacag cgaggctgat    540

gccagtcact gtatccagca gatcctggag gccgttctcc attgtcacca aatgggggtc    600

gtccacagag acctcaagcc ggagaacctg cttctggcca gcaagtgcaa aggggctgca    660

gtgaagctgg cagacttcgg cctagctatc gaggtgcagg gggaccagca ggcatggttt    720

ggtttcgctg gcacaccagg ctacctgtcc cctgaggtcc ttcgcaaaga ggcgtatggc    780

aagcctgtgg acatctgggc atgtggggtg atcctgtaca tcctgctcgt gggctaccca    840

cccttctggg acgaggacca gcacaagctg taccagcaga tcaaggctgg tgcctatgac    900

ttcccgtccc ctgagtggga caccgtcact cctgaagcca aaaacctcat caaccagatg    960

ctgaccatca accctgccaa gcgcatcaca gcccatgagg ccctgaagca cccgtgggtc   1020

tgccaacgct ccacggtagc atccatgatg cacagacagg agactgtgga gtgtctgaaa   1080

aagttcaatg ccaggagaaa gctcaaggga gccatcctca ccaccatgct ggccacacgg   1140

aatttctcag cagccaagag tttactcaac aagaaagcag atggagtcaa gccccagacg   1200

aatagcacca aaaacagtgc agccgccacc agccccaaag ggacgcttcc tcctgccgcc   1260

ctggagtctt ctgacagtgc caataccacc atagaggatg aagacgctaa agcccggaag   1320

caggagatca ttaagaccac ggagcagctc atcgaggccg tcaacaacgg tgactttgag   1380

gcctacgcga aaatctgtga cccagggctg acctcgtttg agcctgaagc actgggcaac   1440

ctggttgaag ggatggactt ccacagattc tacttcgaga acctgctggc caagaacagc   1500

aagccgatcc acacgaccat cctgaaccca cacgtgcacg tcattggaga ggatgccgcc   1560

tgcatcgctt acatccggct cacgcagtac attgacgggc agggccggcc ccgcaccagc   1620

cagtctgagg agacccgcgt gtggcaccgc cgcgacggca agtggcagaa cgtgcacttc   1680

cactgctcgg gcgcgcctgt ggccccgctg cagtgaagag ctgcgccctg gtttcgccgg   1740

acagagttgg tgtttggagc ccgactgccc tcgggcacac ggcctgcctg tcgcatgttt   1800

gtgtctgcct cgttccctcc cctggtgcct gtgtctgcag aaaaacaaga ccagatgtga   1860

tttgttaaaa aaaaacaaaa aaaaaaaaaa aaaaaacaag atgacgacga caaccacaaa   1920

aaaaattgac atcagatgaa atgaaaaaa                                     1949


<210>  2006
<211>  503
<212>  PRT
<213>  Homosapiens

<400>  2006

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ala Asp Gly Val Lys Pro Gln Thr Asn Ser Thr Lys 
                325                 330                 335     


Asn Ser Ala Ala Ala Thr Ser Pro Lys Gly Thr Leu Pro Pro Ala Ala 
            340                 345                 350         


Leu Glu Ser Ser Asp Ser Ala Asn Thr Thr Ile Glu Asp Glu Asp Ala 
        355                 360                 365             


Lys Ala Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln Leu Ile Glu 
    370                 375                 380                 


Ala Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp Pro 
385                 390                 395                 400 


Gly Leu Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly 
                405                 410                 415     


Met Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn Ser 
            420                 425                 430         


Lys Pro Ile His Thr Thr Ile Leu Asn Pro His Val His Val Ile Gly 
        435                 440                 445             


Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr Ile Asp 
    450                 455                 460                 


Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr Arg Val Trp 
465                 470                 475                 480 


His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser Gly 
                485                 490                 495     


Ala Pro Val Ala Pro Leu Gln 
            500             


<210>  2007
<211>  1916
<212>  DNA
<213>  Homosapiens

<400>  2007
gcggcgcgct cctggcgagg acggagcgag cagatctcgc gtgcgctcgc cgcccggcgc     60

agcccagccc ggcccccgcc tggcgccgcg agccgaggtg tctcccgcgc ccgcgcccgt    120

gtcgccgccg tgcccgcgag cgggagccgg agtcgccgcc gcccgagcgc agccgagcgc    180

acgccgagcc cgtccgccgc cgccatggcc accacggtga cctgcacccg cttcaccgac    240

gagtaccagc tctacgagga tattggcaag ggggctttct ctgtggtccg acgctgtgtc    300

aagctctgca ccggccatga gtatgcagcc aagatcatca acaccaagaa gctgtcagcc    360

agagatcacc agaagctgga gagagaggct cggatctgcc gccttctgaa gcattccaac    420

atcgtgcgtc tccacgacag catctccgag gagggcttcc actacctggt cttcgatctg    480

gtcactggtg gggagctctt tgaagacatt gtggcgagag agtactacag cgaggctgat    540

gccagtcact gtatccagca gatcctggag gccgttctcc attgtcacca aatgggggtc    600

gtccacagag acctcaagcc ggagaacctg cttctggcca gcaagtgcaa aggggctgca    660

gtgaagctgg cagacttcgg cctagctatc gaggtgcagg gggaccagca ggcatggttt    720

ggtttcgctg gcacaccagg ctacctgtcc cctgaggtcc ttcgcaaaga ggcgtatggc    780

aagcctgtgg acatctgggc atgtggggtg atcctgtaca tcctgctcgt gggctaccca    840

cccttctggg acgaggacca gcacaagctg taccagcaga tcaaggctgg tgcctatgac    900

ttcccgtccc ctgagtggga caccgtcact cctgaagcca aaaacctcat caaccagatg    960

ctgaccatca accctgccaa gcgcatcaca gcccatgagg ccctgaagca cccgtgggtc   1020

tgccaacgct ccacggtagc atccatgatg cacagacagg agactgtgga gtgtctgaaa   1080

aagttcaatg ccaggagaaa gctcaaggga gccatcctca ccaccatgct ggccacacgg   1140

aatttctcag tgggcagaca gaccaccgct ccggccacaa tgtccaccgc ggcctccggc   1200

accaccatgg ggctggtgga acaagccaag agtttactca acaagaaagc agatggagtc   1260

aaggagcctc aaaccaccgt catccataac ccagtggacg ggattaagga gtcttctgac   1320

agtgccaata ccaccataga ggatgaagac gctaaagccc ggaagcagga gatcattaag   1380

accacggagc agctcatcga ggccgtcaac aacggtgact ttgaggccta cgcattctac   1440

ttcgagaacc tgctggccaa gaacagcaag ccgatccaca cgaccatcct gaacccacac   1500

gtgcacgtca ttggagagga tgccgcctgc atcgcttaca tccggctcac gcagtacatt   1560

gacgggcagg gccggccccg caccagccag tctgaggaga cccgcgtgtg gcaccgccgc   1620

gacggcaagt ggcagaacgt gcacttccac tgctcgggcg cgcctgtggc cccgctgcag   1680

tgaagagctg cgccctggtt tcgccggaca gagttggtgt ttggagcccg actgccctcg   1740

ggcacacggc ctgcctgtcg catgtttgtg tctgcctcgt tccctcccct ggtgcctgtg   1800

tctgcagaaa aacaagacca gatgtgattt gttaaaaaaa aacaaaaaaa aaaaaaaaaa   1860

aaacaagatg acgacgacaa ccacaaaaaa aattgacatc agatgaaatg aaaaaa       1916


<210>  2008
<211>  492
<212>  PRT
<213>  Homosapiens

<400>  2008

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr 
305                 310                 315                 320 


Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly 
                325                 330                 335     


Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
            340                 345                 350         


Lys Glu Pro Gln Thr Thr Val Ile His Asn Pro Val Asp Gly Ile Lys 
        355                 360                 365             


Glu Ser Ser Asp Ser Ala Asn Thr Thr Ile Glu Asp Glu Asp Ala Lys 
    370                 375                 380                 


Ala Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln Leu Ile Glu Ala 
385                 390                 395                 400 


Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Phe Tyr Phe Glu Asn Leu 
                405                 410                 415     


Leu Ala Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn Pro His 
            420                 425                 430         


Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu 
        435                 440                 445             


Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu 
    450                 455                 460                 


Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His 
465                 470                 475                 480 


Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
                485                 490         


<210>  2009
<211>  1877
<212>  DNA
<213>  Homosapiens

<400>  2009
gcggcgcgct cctggcgagg acggagcgag cagatctcgc gtgcgctcgc cgcccggcgc     60

agcccagccc ggcccccgcc tggcgccgcg agccgaggtg tctcccgcgc ccgcgcccgt    120

gtcgccgccg tgcccgcgag cgggagccgg agtcgccgcc gcccgagcgc agccgagcgc    180

acgccgagcc cgtccgccgc cgccatggcc accacggtga cctgcacccg cttcaccgac    240

gagtaccagc tctacgagga tattggcaag ggggctttct ctgtggtccg acgctgtgtc    300

aagctctgca ccggccatga gtatgcagcc aagatcatca acaccaagaa gctgtcagcc    360

agagatcacc agaagctgga gagagaggct cggatctgcc gccttctgaa gcattccaac    420

atcgtgcgtc tccacgacag catctccgag gagggcttcc actacctggt cttcgatctg    480

gtcactggtg gggagctctt tgaagacatt gtggcgagag agtactacag cgaggctgat    540

gccagtcact gtatccagca gatcctggag gccgttctcc attgtcacca aatgggggtc    600

gtccacagag acctcaagcc ggagaacctg cttctggcca gcaagtgcaa aggggctgca    660

gtgaagctgg cagacttcgg cctagctatc gaggtgcagg gggaccagca ggcatggttt    720

ggtttcgctg gcacaccagg ctacctgtcc cctgaggtcc ttcgcaaaga ggcgtatggc    780

aagcctgtgg acatctgggc atgtggggtg atcctgtaca tcctgctcgt gggctaccca    840

cccttctggg acgaggacca gcacaagctg taccagcaga tcaaggctgg tgcctatgac    900

ttcccgtccc ctgagtggga caccgtcact cctgaagcca aaaacctcat caaccagatg    960

ctgaccatca accctgccaa gcgcatcaca gcccatgagg ccctgaagca cccgtgggtc   1020

tgccaacgct ccacggtagc atccatgatg cacagacagg agactgtgga gtgtctgaaa   1080

aagttcaatg ccaggagaaa gctcaaggga gccatcctca ccaccatgct ggccacacgg   1140

aatttctcag cagccaagag tttactcaac aagaaagcag atggagtcaa ggagtcttct   1200

gacagtgcca ataccaccat agaggatgaa gacgctaaag cccggaagca ggagatcatt   1260

aagaccacgg agcagctcat cgaggccgtc aacaacggtg actttgaggc ctacgcgaaa   1320

atctgtgacc cagggctgac ctcgtttgag cctgaagcac tgggcaacct ggttgaaggg   1380

atggacttcc acagattcta cttcgagaac ctgctggcca agaacagcaa gccgatccac   1440

acgaccatcc tgaacccaca cgtgcacgtc attggagagg atgccgcctg catcgcttac   1500

atccggctca cgcagtacat tgacgggcag ggccggcccc gcaccagcca gtctgaggag   1560

acccgcgtgt ggcaccgccg cgacggcaag tggcagaacg tgcacttcca ctgctcgggc   1620

gcgcctgtgg ccccgctgca gtgaagagct gcgccctggt ttcgccggac agagttggtg   1680

tttggagccc gactgccctc gggcacacgg cctgcctgtc gcatgtttgt gtctgcctcg   1740

ttccctcccc tggtgcctgt gtctgcagaa aaacaagacc agatgtgatt tgttaaaaaa   1800

aaacaaaaaa aaaaaaaaaa aaaacaagat gacgacgaca accacaaaaa aaattgacat   1860

cagatgaaat gaaaaaa                                                  1877


<210>  2010
<211>  479
<212>  PRT
<213>  Homosapiens

<400>  2010

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ala Asp Gly Val Lys Glu Ser Ser Asp Ser Ala Asn 
                325                 330                 335     


Thr Thr Ile Glu Asp Glu Asp Ala Lys Ala Arg Lys Gln Glu Ile Ile 
            340                 345                 350         


Lys Thr Thr Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu 
        355                 360                 365             


Ala Tyr Ala Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu 
    370                 375                 380                 


Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe 
385                 390                 395                 400 


Glu Asn Leu Leu Ala Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu 
                405                 410                 415     


Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
            420                 425                 430         


Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser 
        435                 440                 445             


Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln 
    450                 455                 460                 


Asn Val His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
465                 470                 475                 


<210>  2011
<211>  1787
<212>  DNA
<213>  Homosapiens

<400>  2011
gcggcgcgct cctggcgagg acggagcgag cagatctcgc gtgcgctcgc cgcccggcgc     60

agcccagccc ggcccccgcc tggcgccgcg agccgaggtg tctcccgcgc ccgcgcccgt    120

gtcgccgccg tgcccgcgag cgggagccgg agtcgccgcc gcccgagcgc agccgagcgc    180

acgccgagcc cgtccgccgc cgccatggcc accacggtga cctgcacccg cttcaccgac    240

gagtaccagc tctacgagga tattggcaag ggggctttct ctgtggtccg acgctgtgtc    300

aagctctgca ccggccatga gtatgcagcc aagatcatca acaccaagaa gctgtcagcc    360

agagatcacc agaagctgga gagagaggct cggatctgcc gccttctgaa gcattccaac    420

atcgtgcgtc tccacgacag catctccgag gagggcttcc actacctggt cttcgatctg    480

gtcactggtg gggagctctt tgaagacatt gtggcgagag agtactacag cgaggctgat    540

gccagtcact gtatccagca gatcctggag gccgttctcc attgtcacca aatgggggtc    600

gtccacagag acctcaagcc ggagaacctg cttctggcca gcaagtgcaa aggggctgca    660

gtgaagctgg cagacttcgg cctagctatc gaggtgcagg gggaccagca ggcatggttt    720

ggtttcgctg gcacaccagg ctacctgtcc cctgaggtcc ttcgcaaaga ggcgtatggc    780

aagcctgtgg acatctgggc atgtggggtg atcctgtaca tcctgctcgt gggctaccca    840

cccttctggg acgaggacca gcacaagctg taccagcaga tcaaggctgg tgcctatgac    900

ttcccgtccc ctgagtggga caccgtcact cctgaagcca aaaacctcat caaccagatg    960

ctgaccatca accctgccaa gcgcatcaca gcccatgagg ccctgaagca cccgtgggtc   1020

tgccaacgct ccacggtagc atccatgatg cacagacagg agactgtgga gtgtctgaaa   1080

aagttcaatg ccaggagaaa gctcaaggga gccatcctca ccaccatgct ggccacacgg   1140

aatttctcag cccggaagca ggagatcatt aagaccacgg agcagctcat cgaggccgtc   1200

aacaacggtg actttgaggc ctacgcgaaa atctgtgacc cagggctgac ctcgtttgag   1260

cctgaagcac tgggcaacct ggttgaaggg atggacttcc acagattcta cttcgagaac   1320

ctgctggcca agaacagcaa gccgatccac acgaccatcc tgaacccaca cgtgcacgtc   1380

attggagagg atgccgcctg catcgcttac atccggctca cgcagtacat tgacgggcag   1440

ggccggcccc gcaccagcca gtctgaggag acccgcgtgt ggcaccgccg cgacggcaag   1500

tggcagaacg tgcacttcca ctgctcgggc gcgcctgtgg ccccgctgca gtgaagagct   1560

gcgccctggt ttcgccggac agagttggtg tttggagccc gactgccctc gggcacacgg   1620

cctgcctgtc gcatgtttgt gtctgcctcg ttccctcccc tggtgcctgt gtctgcagaa   1680

aaacaagacc agatgtgatt tgttaaaaaa aaacaaaaaa aaaaaaaaaa aaaacaagat   1740

gacgacgaca accacaaaaa aaattgacat cagatgaaat gaaaaaa                 1787


<210>  2012
<211>  449
<212>  PRT
<213>  Homosapiens

<400>  2012

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Arg Lys Gln Glu 
305                 310                 315                 320 


Ile Ile Lys Thr Thr Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp 
                325                 330                 335     


Phe Glu Ala Tyr Ala Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu 
            340                 345                 350         


Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe 
        355                 360                 365             


Tyr Phe Glu Asn Leu Leu Ala Lys Asn Ser Lys Pro Ile His Thr Thr 
    370                 375                 380                 


Ile Leu Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile 
385                 390                 395                 400 


Ala Tyr Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg 
                405                 410                 415     


Thr Ser Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys 
            420                 425                 430         


Trp Gln Asn Val His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu 
        435                 440                 445             


Gln 
    


<210>  2013
<211>  3572
<212>  DNA
<213>  Homosapiens

<400>  2013
ctgaggcggc gctgtgtgtg tgaagcgtac ctagggcggg aggcgacatg gagacagggg     60

cggccgagct gtatgaccag gcccttttgg gcatcctgca gcacgtgggc aacgtccagg    120

atttcctgcg cgttctcttt ggcttcctct accgcaagac agacttctat cgcttgctgc    180

gccacccatc ggaccgcatg ggcttcccgc ccggggccgc gcaggccttg gtgctgcagg    240

tattcaaaac ctttgaccac atggcccgtc aggatgatga gaagagaagg caggaacttg    300

aagagaaaat cagaagaaag gaagaggaag aggccaagac tgtgtcagct gctgcagctg    360

agaaggagcc agtcccagtt ccagtccagg aaatagagat tgactccacc acagaattgg    420

atgggcatca ggaagtagag aaagtgcagc ctccaggccc tgtgaaggaa atggcccatg    480

gttcacagga ggcagaagct ccaggagcag ttgctggtgc tgctgaagtc cctagggaac    540

caccaattct tcccaggatt caggagcagt tccagaaaaa tcccgacagt tacaatggtg    600

ctgtccgaga gaactacacc tggtcacagg actatactga cctggaggtc agggtgccag    660

tacccaagca cgtggtgaag ggaaagcagg tctcagtggc ccttagcagc agctccattc    720

gtgtggccat gctggaggaa aatggggagc gcgtcctcat ggaagggaag ctcacccaca    780

agatcaacac tgagagttct ctctggagtc tcgagcccgg gaagtgcgtt ttggtgaacc    840

tgagcaaggt gggcgagtat tggtggaacg ccatcctgga gggagaagag cccatcgaca    900

ttgacaagat caacaaggag cgctccatgg ccaccgtgga tgaggaggaa caggcggtgt    960

tggacaggct tacctttgac taccaccaga agctgcaggg caagccacag agccatgagc   1020

tgaaagtcca tgagatgctg aagaaggggt gggatgctga aggttctccc ttccgaggcc   1080

agcgattcga ccctgccatg ttcaacatct ccccgggggc tgtgcagttt taatgaccag   1140

aaggaaagga aaccctcgcc ggtggggagg cagagcctta tcctcggctg cccttcttgg   1200

ctccctgcat tccagggact tgctcgtctt gtttacccct agccatcctt tctttcaagg   1260

gtgaaccagg ccttccaccc tgaccttgca tctccagact gttccagaga aggtgcgggg   1320

ccagctgcta tgtggtggcc gctgtggctg acactgagtg aaggtgtttg aaatgcagga   1380

gaggatatcc cagcaaattg ggatcacatg cttttgtctc cacagcaacc agccactgca   1440

ggcagcatgt ctttcctccc ctgctctctg cttgctgttg ttttgacgct attctgcttg   1500

catgtcttct ggttgggatg tggagttgtt gctggactct caggcgaagc tgaagtcatt   1560

gaagtgtgtg aagctctgtg cttgcatgag ggcaagcaag gaatggctgt gcctgaggct   1620

gctctgggaa actccttgcc ccttgacctc ttttgagagc attcacgtgg tcttcttgct   1680

catcccctta taaatgtgct ttgcctgcct cagcctcatg gtcagagcag tggagactgg   1740

agccctgttt gcacgttcta gttgttcgga gaaagcctag gttctgggct caggtccaga   1800

tgcagcgggg attctgttct ctgactgtgg cgaccttgct ttggttcttg ttgaagtgaa   1860

ccaagcccgg ccaccacgca tggcatgctg tgcttggctc cccataagac gtcctctttg   1920

ggtgcacggt gtcaaagtgt gggcaggagt ggagagctgg tgccctcagg aggagaccac   1980

agcatgtcca tcagctcagc agagctcgac agccacaagt cctgagaagc tttgaccttg   2040

aagggcttct gggagaggag gaatttctgc atggggcgtg aaggcacact gtcccaccac   2100

aactgaacca gaagagagtg aagactcccc tcttcccatc ctctgtgcca ggtgccagac   2160

tgtgctcctt ggaacttatg gcccaatctt acctgttctc cagggactgg tcactgcctc   2220

aggaccccca agcctatgcc ctgagccatg gctgctgact gactccagcc aaggtgcaaa   2280

gacgagatta tgagacaggt cctcaggcct gtgttccaag tactcacagg ggctctgggt   2340

gcccatcgcc gggagtatgg ttcagctgcc accggcactg tccatttgcc tgtctgtcaa   2400

gctcagagca tggataagcc acacagcagg gcagtgcacc ctggcaccat gcacggccag   2460

caagaatcaa ggcccgcaga tgctaagagg gcctattgtc aggggaaggt ccccgctcct   2520

gcacactctc tatggatact tgggttgtgg gggctctctt ggagagtaag tttgtggttt   2580

gtttctggtt tacagtggtg gctgacaccc cttgtaagaa agcattcctg ggaagtcttc   2640

tgtgggtcca aacatgttgc tccgatcatc acaggagagc aaaaggccct agataccccc   2700

tttggaatgt gagagtcttg ttgtctgata tttgccactg agctggtgaa gcccctctaa   2760

agagatctcg accctgggga gcagaattct tgtcatctat gaggggtcct gagaaagact   2820

tgtcattttt tttcctggag ttcttcccat tgaggtccta ggatttgcac accactgtcc   2880

cacaagagct ttcctgccta atgaaaggag gtcttgtggt gtgtgtctcc tctcttctct   2940

atagttcccg agttggcccc cattgcagcc cccaccctgt gggtagtctt ccagaagtga   3000

tgcagtggtg tgagatgccc tgcaccttgt tatttgggag actttgagag tcattcactt   3060

ccatggtgac tagtgtttgt tttgcctgat tttatattct gtgttgcatt tctccccact   3120

ccctgccctg ctttaataaa cagcaaacca atatctagga agaatgactg agggatagta   3180

ttgggtattg gccccatggc aggaacagcc acttgcatct ggtcccggtg ccacactgcg   3240

gtgcttggtg tggttgtgga gcctgtccct gcgcgccttg ctcccgttga gccacgctgt   3300

ctggtgggtg attctctgcc ctgagccacc accctggact ggcccagtct ccagagctgg   3360

cacaccctgc ctgttttctc tttttagaca caacagccgc agtttggcca gccactaagt   3420

cccaccagct gaggtccgag gaaagcgggg tgactcattt cccttgtcca gggcccgagg   3480

agagtgaggt gtccagcctg caaagctatt ccagctcctt ggtgttggtt tgcaataaat   3540

tggtatttaa gcaaaaaaaa aaaaaaaaaa aa                                 3572


<210>  2014
<211>  220
<212>  PRT
<213>  Homosapiens

<400>  2014

Met Ala His Gly Ser Gln Glu Ala Glu Ala Pro Gly Ala Val Ala Gly 
1               5                   10                  15      


Ala Ala Glu Val Pro Arg Glu Pro Pro Ile Leu Pro Arg Ile Gln Glu 
            20                  25                  30          


Gln Phe Gln Lys Asn Pro Asp Ser Tyr Asn Gly Ala Val Arg Glu Asn 
        35                  40                  45              


Tyr Thr Trp Ser Gln Asp Tyr Thr Asp Leu Glu Val Arg Val Pro Val 
    50                  55                  60                  


Pro Lys His Val Val Lys Gly Lys Gln Val Ser Val Ala Leu Ser Ser 
65                  70                  75                  80  


Ser Ser Ile Arg Val Ala Met Leu Glu Glu Asn Gly Glu Arg Val Leu 
                85                  90                  95      


Met Glu Gly Lys Leu Thr His Lys Ile Asn Thr Glu Ser Ser Leu Trp 
            100                 105                 110         


Ser Leu Glu Pro Gly Lys Cys Val Leu Val Asn Leu Ser Lys Val Gly 
        115                 120                 125             


Glu Tyr Trp Trp Asn Ala Ile Leu Glu Gly Glu Glu Pro Ile Asp Ile 
    130                 135                 140                 


Asp Lys Ile Asn Lys Glu Arg Ser Met Ala Thr Val Asp Glu Glu Glu 
145                 150                 155                 160 


Gln Ala Val Leu Asp Arg Leu Thr Phe Asp Tyr His Gln Lys Leu Gln 
                165                 170                 175     


Gly Lys Pro Gln Ser His Glu Leu Lys Val His Glu Met Leu Lys Lys 
            180                 185                 190         


Gly Trp Asp Ala Glu Gly Ser Pro Phe Arg Gly Gln Arg Phe Asp Pro 
        195                 200                 205             


Ala Met Phe Asn Ile Ser Pro Gly Ala Val Gln Phe 
    210                 215                 220 


<210>  2015
<211>  1942
<212>  DNA
<213>  Homosapiens

<400>  2015
cccacgcgtc cgcccacgcg tccgggtgcc actcgcgcgc cggccgcgct ccgggcttct     60

cttttccctc cgacgcgcca cggctgccca gacattccgg ctgccgggtc tggagagctc    120

cccgaacccc tccgcggaga ggagcgaggc ggcgccaggg tggcccccgg ggcgcgcttg    180

gtctcggaga agcggggacg aggccggagg atgagcgact gagggcgacg cgggcactga    240

cgcgagttgg ggccgcgact accggcagct gacagcgcga tgagcgactc cccagagacg    300

ccctagcccg gtgtgcgcgc caggcggagc gcgcaggtgg ggctgggctg ttagtggtcc    360

gccccacgcg ggtcgccggc cggcccagga tgggcgctgg caacccgggc ccgcgcccgc    420

cgctgctacc cctgcgcccg ctgcgagccc ggcgtccggc ccgcgccctg cgctcatgga    480

cggcggctcc cggctggcgg cggcgcgccc ccgggctgtg aatgcgactc gcccctcggc    540

cgcgctcccc gcccgcccgc ccgccgggac gtggtagggg atgcccagct ccactgcgat    600

ggcagttggc gcgctctcca gttccctcct ggtcacctgc tgcctgatgg tggctctgtg    660

cagtccgagc atcccgctgg agaagctggc ccaggcacca gagcagccgg gccaggagaa    720

gcgtgagcac gccactcggg acggcccggg gcgggtgaac gagctcgggc gcccggcgag    780

ggacgagggc ggcagcggcc gggactggaa gagcaagagc ggccgtgggc tcgccggccg    840

tgagccgtgg agcaagctga agcaggcctg ggtctcccag ggcgggggcg ccaaggccgg    900

ggatctgcag gtccggcccc gcggggacac cccgcaggcg gaagccctgg ccgcagccgc    960

ccaggacgcg attggcccgg aactcgcgcc cacgcccgag ccacccgagg agtacgtgta   1020

cccggactac cgtggcaagg gctgcgtgga cgagagcggc ttcgtgtacg cgatcgggga   1080

gaagttcgcg ccgggcccct cggcctgccc gtgcctgtgc accgaggagg ggccgctgtg   1140

cgcgcagccc gagtgcccga ggctgcaccc gcgctgcatc cacgtcgaca cgagccagtg   1200

ctgcccgcag tgcaaggaga ggaagaacta ctgcgagttc cggggcaaga cctatcagac   1260

tttggaggag ttcgtggtgt ctccatgcga gaggtgtcgc tgtgaagcca acggtgaggt   1320

gctatgcaca gtgtcagcgt gtccccagac ggagtgtgtg gaccctgtgt acgagcctga   1380

tcagtgctgt cccatctgca aaaatggtcc aaactgcttt gcagaaaccg cggtgatccc   1440

tgctggcaga gaagtgaaga ctgacgagtg caccatatgc cactgtactt atgaggaagg   1500

cacatggaga atcgagcggc aggccatgtg cacgagacat gaatgcaggc aaatgtagac   1560

gcttcccaga acacaaactc tgactttttc tagaacattt tactgatgtg aacattctag   1620

atgactctgg gaactatcag tcaaagaaga cttttgatga ggaataatgg aaaattgttg   1680

gtacttttcc ttttcttgat aacagttact acaacagaag gaaatggata tatttcaaaa   1740

catcaacaag aactttgggc ataaaatcct tctctaaata aatgtgctat tttcacagta   1800

agtacacaaa agtacactat tatatatcaa atgtatttct ataatccctc cattagagag   1860

cttatataag tgttttctat agatgcagat taaaaatgct gtgttgtcaa ccgtcaaaaa   1920

aaaaaaaaaa aaaaaaaaaa aa                                            1942


<210>  2016
<211>  325
<212>  PRT
<213>  Homosapiens

<400>  2016

Met Pro Ser Ser Thr Ala Met Ala Val Gly Ala Leu Ser Ser Ser Leu 
1               5                   10                  15      


Leu Val Thr Cys Cys Leu Met Val Ala Leu Cys Ser Pro Ser Ile Pro 
            20                  25                  30          


Leu Glu Lys Leu Ala Gln Ala Pro Glu Gln Pro Gly Gln Glu Lys Arg 
        35                  40                  45              


Glu His Ala Thr Arg Asp Gly Pro Gly Arg Val Asn Glu Leu Gly Arg 
    50                  55                  60                  


Pro Ala Arg Asp Glu Gly Gly Ser Gly Arg Asp Trp Lys Ser Lys Ser 
65                  70                  75                  80  


Gly Arg Gly Leu Ala Gly Arg Glu Pro Trp Ser Lys Leu Lys Gln Ala 
                85                  90                  95      


Trp Val Ser Gln Gly Gly Gly Ala Lys Ala Gly Asp Leu Gln Val Arg 
            100                 105                 110         


Pro Arg Gly Asp Thr Pro Gln Ala Glu Ala Leu Ala Ala Ala Ala Gln 
        115                 120                 125             


Asp Ala Ile Gly Pro Glu Leu Ala Pro Thr Pro Glu Pro Pro Glu Glu 
    130                 135                 140                 


Tyr Val Tyr Pro Asp Tyr Arg Gly Lys Gly Cys Val Asp Glu Ser Gly 
145                 150                 155                 160 


Phe Val Tyr Ala Ile Gly Glu Lys Phe Ala Pro Gly Pro Ser Ala Cys 
                165                 170                 175     


Pro Cys Leu Cys Thr Glu Glu Gly Pro Leu Cys Ala Gln Pro Glu Cys 
            180                 185                 190         


Pro Arg Leu His Pro Arg Cys Ile His Val Asp Thr Ser Gln Cys Cys 
        195                 200                 205             


Pro Gln Cys Lys Glu Arg Lys Asn Tyr Cys Glu Phe Arg Gly Lys Thr 
    210                 215                 220                 


Tyr Gln Thr Leu Glu Glu Phe Val Val Ser Pro Cys Glu Arg Cys Arg 
225                 230                 235                 240 


Cys Glu Ala Asn Gly Glu Val Leu Cys Thr Val Ser Ala Cys Pro Gln 
                245                 250                 255     


Thr Glu Cys Val Asp Pro Val Tyr Glu Pro Asp Gln Cys Cys Pro Ile 
            260                 265                 270         


Cys Lys Asn Gly Pro Asn Cys Phe Ala Glu Thr Ala Val Ile Pro Ala 
        275                 280                 285             


Gly Arg Glu Val Lys Thr Asp Glu Cys Thr Ile Cys His Cys Thr Tyr 
    290                 295                 300                 


Glu Glu Gly Thr Trp Arg Ile Glu Arg Gln Ala Met Cys Thr Arg His 
305                 310                 315                 320 


Glu Cys Arg Gln Met 
                325 


<210>  2017
<211>  1177
<212>  DNA
<213>  Homosapiens

<400>  2017
ccgcgcggac ggtgggcagg cgacggcggc gtgtggatgg aggccttcgc ccttggccca     60

gcgcggcggg gcaggcggcg gacccgggcc gccggctccc tgctctctcg ggccgccatc    120

ctcctcttta tctccgcctt cctggtgcgg gtgccctcat cagttggaca cttggttcga    180

ttaccaagag cttttcgctt gaccaaagat tcagtgaaaa tagtgggatc aacaagtttt    240

ccagtgaaag cgtatgtcat gctccatcaa aagagtccac acgtgttatg tgtaacgcaa    300

caactgcgaa atgctgaact gatagaccca tcattccaat ggtatgggcc taaaggaaaa    360

gttgtttcag tagaaaaccg cactgcacaa ataacatcca caggaagcct tgtattccaa    420

aattttgagg agagtatgag tggaatttat acatgtttcc tcgaatataa acctactgtg    480

gaagaaattg ttaaacgtct tcaactaaaa tatgctatat atgcttatcg tgagcctcat    540

tattattatc agttcacagc tcgatatcat gcagtcccct gcaatagcat ttataatatt    600

tcttttgaga agaaacttct tcagatttta agcaaactgc ttcttgacct ttcatgtgaa    660

atttccttac ttaagtctga atgccatcgc gttaaaatgc aaagagctgg tttgcaaaat    720

gaattgttct ttgcattttc agtttcatct ctagacactg aaaaaggacc caagcgatgt    780

acagaccata actgtgaacc ttacaaaaga ctttttaagg ctaaaaatct catagagaga    840

ttttttaatc aacaagtaga aattcttggc agacgtgcag aacaattacc tcaaatatac    900

tatattgaag gtactctcca aatggtttgg attaatcgct gctttccagg atatggaatg    960

aatgtccagc aacatccaaa atgtcctgag tgctgtgtga tctgcagccc tggatcatat   1020

aacccccgtg atggaattca ttgccttcaa tgcaatagca gcctggtgta tggagcaaaa   1080

acgtgcttat aagccattat cttcagttat tcagtggttt attaaatgca aagtatatat   1140

ttgaaatatt aacataataa attattatgc caaaatt                            1177


<210>  2018
<211>  351
<212>  PRT
<213>  Homosapiens

<400>  2018

Met Glu Ala Phe Ala Leu Gly Pro Ala Arg Arg Gly Arg Arg Arg Thr 
1               5                   10                  15      


Arg Ala Ala Gly Ser Leu Leu Ser Arg Ala Ala Ile Leu Leu Phe Ile 
            20                  25                  30          


Ser Ala Phe Leu Val Arg Val Pro Ser Ser Val Gly His Leu Val Arg 
        35                  40                  45              


Leu Pro Arg Ala Phe Arg Leu Thr Lys Asp Ser Val Lys Ile Val Gly 
    50                  55                  60                  


Ser Thr Ser Phe Pro Val Lys Ala Tyr Val Met Leu His Gln Lys Ser 
65                  70                  75                  80  


Pro His Val Leu Cys Val Thr Gln Gln Leu Arg Asn Ala Glu Leu Ile 
                85                  90                  95      


Asp Pro Ser Phe Gln Trp Tyr Gly Pro Lys Gly Lys Val Val Ser Val 
            100                 105                 110         


Glu Asn Arg Thr Ala Gln Ile Thr Ser Thr Gly Ser Leu Val Phe Gln 
        115                 120                 125             


Asn Phe Glu Glu Ser Met Ser Gly Ile Tyr Thr Cys Phe Leu Glu Tyr 
    130                 135                 140                 


Lys Pro Thr Val Glu Glu Ile Val Lys Arg Leu Gln Leu Lys Tyr Ala 
145                 150                 155                 160 


Ile Tyr Ala Tyr Arg Glu Pro His Tyr Tyr Tyr Gln Phe Thr Ala Arg 
                165                 170                 175     


Tyr His Ala Val Pro Cys Asn Ser Ile Tyr Asn Ile Ser Phe Glu Lys 
            180                 185                 190         


Lys Leu Leu Gln Ile Leu Ser Lys Leu Leu Leu Asp Leu Ser Cys Glu 
        195                 200                 205             


Ile Ser Leu Leu Lys Ser Glu Cys His Arg Val Lys Met Gln Arg Ala 
    210                 215                 220                 


Gly Leu Gln Asn Glu Leu Phe Phe Ala Phe Ser Val Ser Ser Leu Asp 
225                 230                 235                 240 


Thr Glu Lys Gly Pro Lys Arg Cys Thr Asp His Asn Cys Glu Pro Tyr 
                245                 250                 255     


Lys Arg Leu Phe Lys Ala Lys Asn Leu Ile Glu Arg Phe Phe Asn Gln 
            260                 265                 270         


Gln Val Glu Ile Leu Gly Arg Arg Ala Glu Gln Leu Pro Gln Ile Tyr 
        275                 280                 285             


Tyr Ile Glu Gly Thr Leu Gln Met Val Trp Ile Asn Arg Cys Phe Pro 
    290                 295                 300                 


Gly Tyr Gly Met Asn Val Gln Gln His Pro Lys Cys Pro Glu Cys Cys 
305                 310                 315                 320 


Val Ile Cys Ser Pro Gly Ser Tyr Asn Pro Arg Asp Gly Ile His Cys 
                325                 330                 335     


Leu Gln Cys Asn Ser Ser Leu Val Tyr Gly Ala Lys Thr Cys Leu 
            340                 345                 350     


<210>  2019
<211>  5616
<212>  DNA
<213>  Homosapiens

<400>  2019
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg     60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac    120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc    180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga    240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc    300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc    360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt    420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc    480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga    540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc    600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga    660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac    720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg    780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc    840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag    900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca    960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc   1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat   1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat   1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg   1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac   1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac   1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt   1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta   1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat   1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt   1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat   1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa   1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc   1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg   1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag   1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc   1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac   1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga   2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac   2100

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg   2160

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg   2220

gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg   2280

ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct   2340

cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg   2400

ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt   2460

aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa   2520

atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg   2580

ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc   2640

ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt   2700

gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg   2760

gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg   2820

gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc   2880

aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg   2940

agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc   3000

cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata   3060

tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc   3120

ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac   3180

cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac   3240

cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc   3300

ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg   3360

agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt   3420

cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact   3480

gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc   3540

aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg   3600

cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat   3660

ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc   3720

cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc   3780

aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta   3840

agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc   3900

ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac   3960

agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta   4020

gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac   4080

tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat   4140

ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg   4200

ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag   4260

gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag   4320

gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt   4380

ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta   4440

ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga   4500

agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta   4560

cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt   4620

cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag   4680

caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc   4740

atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt   4800

tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg   4860

catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca   4920

accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc   4980

aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc   5040

cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag   5100

ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg   5160

aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc   5220

agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg   5280

gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg   5340

actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc   5400

catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca   5460

gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca   5520

gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa   5580

ctatattcat ttccactcta aaaaaaaaaa aaaaaa                             5616


<210>  2020
<211>  1210
<212>  PRT
<213>  Homosapiens

<400>  2020

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  2021
<211>  2239
<212>  DNA
<213>  Homosapiens

<400>  2021
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg     60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac    120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc    180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga    240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc    300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc    360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt    420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc    480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga    540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc    600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga    660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac    720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg    780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc    840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag    900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca    960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc   1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat   1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat   1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg   1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac   1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac   1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt   1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta   1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat   1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt   1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat   1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa   1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc   1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg   1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag   1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc   1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac   1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga   2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac   2100

ctgtgccatc caaactgcac ctacgggtcc taataaatct tcactgtctg actttagtct   2160

cccactaaaa ctgcatttcc tttctacaat ttcaatttct ccctttgctt caaataaagt   2220

cctgacacta ttcatttga                                                2239


<210>  2022
<211>  628
<212>  PRT
<213>  Homosapiens

<400>  2022

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Ser 
625             


<210>  2023
<211>  1595
<212>  DNA
<213>  Homosapiens

<400>  2023
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg     60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac    120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc    180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga    240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc    300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc    360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt    420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc    480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga    540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc    600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga    660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac    720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg    780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc    840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag    900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca    960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc   1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat   1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat   1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg   1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac   1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac   1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt   1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta   1440

aaggaaatca caggtttgag ctgaattatc acatgaatat aaatgggaaa tcagtgtttt   1500

agagagagaa cttttcgaca tatttcctgt tcccttggaa taaaaacatt tcttctgaaa   1560

ttttaccgtt aaaaaaaaaa aaaaaaaaaa aaaaa                              1595


<210>  2024
<211>  405
<212>  PRT
<213>  Homosapiens

<400>  2024

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Leu Ser 
                405 


<210>  2025
<211>  2865
<212>  DNA
<213>  Homosapiens

<400>  2025
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg     60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac    120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc    180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga    240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc    300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc    360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt    420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc    480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga    540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc    600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga    660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac    720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg    780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc    840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag    900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca    960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc   1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat   1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat   1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg   1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac   1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac   1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt   1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta   1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat   1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt   1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat   1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa   1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc   1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg   1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag   1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc   1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac   1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga   2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac   2100

ctgtgccatc caaactgcac ctacgggcca ggaaatgaga gtctcaaagc catgttattc   2160

tgccttttta aactatcatc ctgtaatcaa agtaatgatg gcagcgtgtc ccaccagagc   2220

gggagcccag ctgctcagga gtcatgctta ggatggatcc cttctcttct gccgtcagag   2280

tttcagctgg gttggggtgg atgcagccac ctccatgcct ggccttctgc atctgtgatc   2340

atcacggcct cctcctgcca ctgagcctca tgccttcacg tgtctgttcc ccccgctttt   2400

cctttctgcc acccctgcac gtgggccgcc aggttcccaa gagtatccta cccatttcct   2460

tccttccact ccctttgcca gtgcctctca ccccaactag tagctaacca tcacccccag   2520

gactgacctc ttcctcctcg ctgccagatg attgttcaaa gcacagaatt tgtcagaaac   2580

ctgcagggac tccatgctgc cagccttctc cgtaattagc atggccccag tccatgcttc   2640

tagccttggt tccttctgcc cctctgtttg aaattctaga gccagctgtg ggacaattat   2700

ctgtgtcaaa agccagatgt gaaaacatct caataacaaa ctggctgctt tgttcaatgc   2760

tagaacaacg cctgtcacag agtagaaact caaaaatatt tgctgagtga atgaacaaat   2820

gaataaatgc ataataaata attaaccacc aatccaacat ccaga                   2865


<210>  2026
<211>  705
<212>  PRT
<213>  Homosapiens

<400>  2026

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Pro Gly Asn Glu Ser Leu Lys Ala Met Leu Phe Cys Leu 
625                 630                 635                 640 


Phe Lys Leu Ser Ser Cys Asn Gln Ser Asn Asp Gly Ser Val Ser His 
                645                 650                 655     


Gln Ser Gly Ser Pro Ala Ala Gln Glu Ser Cys Leu Gly Trp Ile Pro 
            660                 665                 670         


Ser Leu Leu Pro Ser Glu Phe Gln Leu Gly Trp Gly Gly Cys Ser His 
        675                 680                 685             


Leu His Ala Trp Pro Ser Ala Ser Val Ile Ile Thr Ala Ser Ser Cys 
    690                 695                 700                 


His 
705 


<210>  2027
<211>  210
<212>  DNA
<213>  Homosapiens

<400>  2027
atgctccttc tggatcctaa gcccactgac ctgaccacca gtcacttggc ccttgtccac     60

atcatgatgc tgctcaccat tgtgttcttg gtgtctccag acctttttga gtcccttcat    120

tttgacttca agtgtaagac gcttttctac ctgagcaggg tgatgaggga cctctgcgtc    180

tgcaccacct gcctcctgag cacgctctag                                     210


<210>  2028
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  2028

Met Leu Leu Leu Asp Pro Lys Pro Thr Asp Leu Thr Thr Ser His Leu 
1               5                   10                  15      


Ala Leu Val His Ile Met Met Leu Leu Thr Ile Val Phe Leu Val Ser 
            20                  25                  30          


Pro Asp Leu Phe Glu Ser Leu His Phe Asp Phe Lys Cys Lys Thr Leu 
        35                  40                  45              


Phe Tyr Leu Ser Arg Val Met Arg Asp Leu Cys Val Cys Thr Thr Cys 
    50                  55                  60                  


Leu Leu Ser Thr Leu 
65                  


<210>  2029
<211>  3934
<212>  DNA
<213>  Homosapiens

<400>  2029
gcttctctgc gcccagagct ccagtccttc tcttcactgc tctgcgtcct ctgctcctgg     60

aggccaagcc tctgtggcct tgtgtcctgc aagtattcgc agatttatgg ctaaaagacc    120

gggaccccct ggaagccgag aaatgggact gttgacattc agagacatag ctatagaatt    180

ttctctggcg gaatggcaat gcctggatca tgctcagcag aatttatata gagatgtgat    240

gttagagaac tacagaaacc tggtctccct gggtattgct gtctctaagc cagacttgat    300

cacctgtctg gagcaaaata aagagcccca gaatataaag agaaatgaga tggtagccaa    360

acacccagtt acatgttctc atttcaccca agaccttcag tcagagcagg gcataaaaga    420

ttcactccaa aaagtgatac tgagaagata tggaaaatgt ggacaggagg atttacaagt    480

aaaaaaatgc tgtaaaagtg taggtgagtg tgaggtgcac aaaggaggtt ataattatgt    540

taaccaatgt ttgtcagcta cccaaaacaa aacatttcag actcataaat gcgtcaaagt    600

ctttggtaaa ttttcaaatt ccaatagaca caagacaaga catactggaa agaaacattt    660

caaatgtaaa aacgatggca aatcattttg catgctttca cgcctaaatc aacatcagat    720

aattcatact agggagaagt cttacaaatg tgaagaatgt ggcaaatcct ttaactgctc    780

ttcaaccctt actagacata aaagaattca tactggagag aaaccctaca gatgtgagga    840

atgtggcaaa gcttttagct ggtctgcatc ccttactaaa cataagagaa ttcatactgg    900

agagaaacct tacacatgtg aagaacgtgg caaagtcttt agccgctcaa cacttactaa    960

ctacaagaga attcatactg gagagaaacc ctacacatgt gaagaatgtg gcaaagcctt   1020

tagccgctct tcaacactta ctaaccacaa gagaattcat actggagaga gaccctacaa   1080

atgtgaagaa tgtggcaaag cctttagctt atcctcaacc cttaagaaac ataagatagt   1140

tcatactggg gagaaactct acacatgtga agaatgtggg aaagccttta ccttctcctc   1200

aactctaaat actcataaga ggattcatac tggagagaaa ccctacactt gtgaagaatg   1260

tggcaaagcc tttagcttac cctcaacctt cacttaccac aagagaactc atactggaga   1320

gaaaccctac aaatgtgaag aatgtggcaa agcctttaac tgctcctcaa cccttaagaa   1380

acataagata attcatactg gagagaaact ctacaaatgt aaagaatgtg ggaaagcctt   1440

taccttctcc tcaactctaa atactcataa gaggattcat actggagaga aaccctacaa   1500

atgtgaagaa tgtgaccaaa cttttaagtg gcattcaagt cttgctaatc ataagaatat   1560

gcatactgga gagaaaccct acaaatatga ataatgtggt aaagtccagc cctcaggcct   1620

tataatacat aaaataattt atactggaaa aaatcactac aagtgtggag aatgtggcca   1680

attctttaac cagttccaaa ccactgctgt ccataagata attcatattg gacaaaagtc   1740

ttataaatgt aaaaaaaaaa gtaacagcct gggtgacaga gcaagaatcc atcttaaaaa   1800

aaaaaaaaaa gcgtaaatgt gattactgta aaaagacctt tcagaaaaca taggccttta   1860

aagcaaagac tatttattct aaagacaaac attaaaacat aaagaggatt gtgtagtacc   1920

tttatttgta ttacggattt tattgtacac attttatatc aaaggaaaac cctgaaacag   1980

atgctcaaac tttgttgaac atcggagaat ttatattgga gagaaagtgt aaatgaatgt   2040

caaaaaatat ttgttcaaaa actacagttt agaaaacact agtttatact aaaaaaatat   2100

ttttgcagat gcagtaaatg gggaaaatat gtttaatcaa aaattaagtc tacataaaca   2160

tttgaggatt cacagtagaa agaatgaagg tgctgaaact tcagacatta cactaaatca   2220

gagtgttgag tgtaaaaaag atataaatct aacaatataa atttaaagaa gtagatttat   2280

ttggagattt ataattacat tcgaggtatg cttctttctt tgtaaaaaaa aatatagatt   2340

ttctgaaaag caaatagtaa tgtaactcac atttcaaatt acttcatgtt gatcctttct   2400

tcccattgtt tctgtgaaag tattggacca attgttgaat cagagatatg agattgtttt   2460

ttataggtgt ccattattca tgaactttcc tatggatgag taaggacatt aagttgtaag   2520

atgcataatg aaaatctaaa tggagaggtt ctttgtggtt gacttataac attgttttag   2580

tgatgtataa ggcgagcgtt cagagtaata ttctaaattc tagtgaggaa aacctttgaa   2640

cgtcagtagt aaattatttt atcaattgta cctttatgta aacaaagttg tttttaatga   2700

gctaaaacta ttgtgctttg aaagaagtat taagctgcca ttgactctat cgtgtctcat   2760

cttaaggttc tgcgtaaaag atggtgacaa tatactattt gttaatgtag gggaatgaca   2820

tcactagtag tctctttttt gccagtgttt ttgtttgttt gttttgagac taagtcttac   2880

tctgtcaccc agactggggt gcagtggtgc gatctcagct cactgcaacc tccacctcct   2940

gggtccaagt gattctcctg cttcagcctc acaagtagct ggaactagag gcaggcacca   3000

ccactcctgg ctaatttttg tatttttagt agagatgagg tttccccatg ttggccaggc   3060

tggtctcaaa ctcctgacct caggtgatac acccacctcg gtgtaccgaa gtgctgggat   3120

tacaggcatg agccaccatg cctggcctac tagaggtttt acacagcaaa caagttgaag   3180

aattttgttc ccataggaca aatttgtact tttttacctt atttaatttt tttttaattt   3240

ttgtgggtag tgtgcataca cacttatggc atatatgaga tatgttaaca catgcacata   3300

atatttaatg atcacaacag agtaaatgag gcattcatca ccttgagcat gtatttatcc   3360

tttgtattac aaacaatccc attatacagt tttagttatt tcaatatgtg caattgaatt   3420

actattaacc acagggtcat tttatgatca taaaaattac atgagtataa ttaataccca   3480

tacatttctg agtcttgatt aaatattttt aaaattttgt tttataaatt ttttgcacat   3540

gtggcatctc tgctgacaaa caaaaacaga cttttagttt caatttacat agagttacat   3600

atacaaatat attactctaa agatatacca gccgagcaca gtggctccca gcattttggg   3660

agcctgaggt gggaggatca tttgaggtta ggagttcaag accagcctgg ccaacatggt   3720

gaaaccccat ctctactaaa aatacaaaaa attagctggg catggtggtg catgcccatg   3780

gtcccagtta ctcaggaggc tgaggcagga gaattgcttg aacctcggag gtggaggtag   3840

cagtgagctg agatggtgct actgcactcc agcctgggtg aaagagcgag aaaccatctc   3900

aaaaaaaaaa ataaataaat aaaagatata cctt                               3934


<210>  2030
<211>  495
<212>  PRT
<213>  Homosapiens

<400>  2030

Met Ala Lys Arg Pro Gly Pro Pro Gly Ser Arg Glu Met Gly Leu Leu 
1               5                   10                  15      


Thr Phe Arg Asp Ile Ala Ile Glu Phe Ser Leu Ala Glu Trp Gln Cys 
            20                  25                  30          


Leu Asp His Ala Gln Gln Asn Leu Tyr Arg Asp Val Met Leu Glu Asn 
        35                  40                  45              


Tyr Arg Asn Leu Val Ser Leu Gly Ile Ala Val Ser Lys Pro Asp Leu 
    50                  55                  60                  


Ile Thr Cys Leu Glu Gln Asn Lys Glu Pro Gln Asn Ile Lys Arg Asn 
65                  70                  75                  80  


Glu Met Val Ala Lys His Pro Val Thr Cys Ser His Phe Thr Gln Asp 
                85                  90                  95      


Leu Gln Ser Glu Gln Gly Ile Lys Asp Ser Leu Gln Lys Val Ile Leu 
            100                 105                 110         


Arg Arg Tyr Gly Lys Cys Gly Gln Glu Asp Leu Gln Val Lys Lys Cys 
        115                 120                 125             


Cys Lys Ser Val Gly Glu Cys Glu Val His Lys Gly Gly Tyr Asn Tyr 
    130                 135                 140                 


Val Asn Gln Cys Leu Ser Ala Thr Gln Asn Lys Thr Phe Gln Thr His 
145                 150                 155                 160 


Lys Cys Val Lys Val Phe Gly Lys Phe Ser Asn Ser Asn Arg His Lys 
                165                 170                 175     


Thr Arg His Thr Gly Lys Lys His Phe Lys Cys Lys Asn Asp Gly Lys 
            180                 185                 190         


Ser Phe Cys Met Leu Ser Arg Leu Asn Gln His Gln Ile Ile His Thr 
        195                 200                 205             


Arg Glu Lys Ser Tyr Lys Cys Glu Glu Cys Gly Lys Ser Phe Asn Cys 
    210                 215                 220                 


Ser Ser Thr Leu Thr Arg His Lys Arg Ile His Thr Gly Glu Lys Pro 
225                 230                 235                 240 


Tyr Arg Cys Glu Glu Cys Gly Lys Ala Phe Ser Trp Ser Ala Ser Leu 
                245                 250                 255     


Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Glu 
            260                 265                 270         


Glu Arg Gly Lys Val Phe Ser Arg Ser Thr Leu Thr Asn Tyr Lys Arg 
        275                 280                 285             


Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Lys Ala 
    290                 295                 300                 


Phe Ser Arg Ser Ser Thr Leu Thr Asn His Lys Arg Ile His Thr Gly 
305                 310                 315                 320 


Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Leu Ser 
                325                 330                 335     


Ser Thr Leu Lys Lys His Lys Ile Val His Thr Gly Glu Lys Leu Tyr 
            340                 345                 350         


Thr Cys Glu Glu Cys Gly Lys Ala Phe Thr Phe Ser Ser Thr Leu Asn 
        355                 360                 365             


Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Glu Glu 
    370                 375                 380                 


Cys Gly Lys Ala Phe Ser Leu Pro Ser Thr Phe Thr Tyr His Lys Arg 
385                 390                 395                 400 


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala 
                405                 410                 415     


Phe Asn Cys Ser Ser Thr Leu Lys Lys His Lys Ile Ile His Thr Gly 
            420                 425                 430         


Glu Lys Leu Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Thr Phe Ser 
        435                 440                 445             


Ser Thr Leu Asn Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr 
    450                 455                 460                 


Lys Cys Glu Glu Cys Asp Gln Thr Phe Lys Trp His Ser Ser Leu Ala 
465                 470                 475                 480 


Asn His Lys Asn Met His Thr Gly Glu Lys Pro Tyr Lys Tyr Glu 
                485                 490                 495 


<210>  2031
<211>  4802
<212>  DNA
<213>  Homosapiens

<400>  2031
tgggaaataa agtcatttgt atgtttttct ctcttgcaca gcctaaaatg accaatgtgt     60

gatttcagtg gaataaatgg cgcccaaagt cacagatgct atagtctggt atcaaaagaa    120

ggagtttctc tctgtggcca ccaccgcccc aggcccacag caagtactgc ctggctactg    180

ccagtgttca ctcaaggacc aagggctctt cattcagtgt ttgattggag catatgatca    240

acaaatatgg gaaaaatctg ttgaacagag agaaatcaag tttattaaac tggggctaag    300

gaataaacca aagaaaacag cacatgtgaa accagacctc atagatgttg atcttgtaag    360

agggtctgca tttgcaaagg caaagcctga aagtccttgg acttctctga ccagaaaggg    420

aattgttcga gttgtatttt tccccttttt cttccggtgg tggttacaag taacatcaaa    480

ggtcatcttt ttctggcttc ttgtccttta tcttcttcaa gttgctgcaa tagtattatt    540

ctgctccact tctagcccac acagcatacc tctgacagag gtgattgggc cgatatggct    600

gatgctgctc ctgggaactg tgcattgcca gattgtttcc acaagaacac ccaaacctcc    660

tctaagtaca gggggtaaaa gaagaaggaa attaagaaaa gcagcccatt tggaagtaca    720

tagggaagga gatggttcta gtaccacaga taacacacaa gagggagcag ttcagaacca    780

cggtacaagc acctctcaca gcgttggcac tgtcttcaga gatctctggc atgctgcttt    840

ctttttatca ggatcaaaga aagcaaagaa ttcaattgat aaatcaactg aaactgacaa    900

tggctatgta tcccttgatg ggaagaagac tgttaaaagc ggtgaagatg gaatacaaaa    960

ccatgaacct cagtgtgaaa ctattcgacc agaagagaca gcctggaaca caggaacact   1020

gaggaatggt cctagcaaag atacccaaag gacaataaca aatgtctctg atgaagtctc   1080

cagtgaggaa ggtcctgaaa caggatactc attacgtcgt catgtggaca ggacttctga   1140

aggtgttctt cggaatagaa agtcacacca ttataagaaa cattacccta atgaggacgc   1200

ccctaaatcg ggtactagtt gcagctctcg ctgttcaagt tccagacagg attctgagag   1260

tgcaaggcca gaatctgaaa cagaagatgt gttatgggaa gacttgttac attgtgcaga   1320

atgccattca tcttgtacca gtgagacaga tgtggaaaat catcagatta atccatgtgt   1380

gaaaaaagaa tatagagatg acccttttca tcagagtcat ttgccctggc tccatagttc   1440

ccacccagga ttagaaaaaa taagtgctat agtatgggaa ggtaatgatt gtaagaaagc   1500

agacatgtct gtacttgaaa tcagtggaat gataatgaac agagtgaaca gccatatacc   1560

aggaatagga taccagattt ttggaaatgc agtctctctc atactgggtt taactccatt   1620

tgttttccga ctttctcaag ctacagactt ggaacaactc acagcacatt ctgcttcaga   1680

actttatgtg attgcatttg gttctaatga agatgtcata gttctttcta tggttataat   1740

aagttttgtg gttcgcgtgt ctcttgtgtg gattttcttt tttttgctct gtgtagcaga   1800

aagaacttat aaacagcgat tactttttgc aaaactcttt ggacatttaa catctgcaag   1860

gagggctcga aaatctgagg ttcctcattt ccggttgaag aaagtacaga atataaaaat   1920

gtggctatct ctccgttcct atcttaagcg tcgaggtcct cagcgatcag ttgatgtaat   1980

agtttcatct gctttcttat tgactatctc agttgtattt atctgttgtg cccagctact   2040

tcatgtacac gagatcttcc ttgattgtca ctacaattgg gaattggtaa tctggtgcat   2100

ctcgttaaca ctttttctcc taagatttgt tacccttgga tcagaaacaa gtaaaaaata   2160

tagtaatacc tcaatattac ttactgaaca gataaacctc tacttgaaga tggagaaaaa   2220

acctaacaaa aaggaggaac tgacactagt gaataatgtt ttaaaactgg ctactaaact   2280

gctaaaggag ttggacagtc cttttagatt atatgggctt acaatgaatc cgctgcttta   2340

taacatcacc caggttgtta tcctgtcagc tgtttctggt gttatcagtg acttgcttgg   2400

atttaattta aagctatgga agattaagtc atgacaattc aaagaaaaga agatgtagcc   2460

tcttttccag aataagagta ctgactaagc tgcctgaaag cttgtcactg attctttgct   2520

tcaggagtct cagctaggga gttgaagtgt ttacatcaga ctgtcttgtg caattcttat   2580

atttatttta ctggttcact tttttttaca tttattttag tctttatatt tttattttta   2640

agcattgatg tacttagttg ttgaaagggt gatgaaactg atatccagat acttgagatc   2700

ctggtaattg gtcataaata attggcaaaa taacaaattg tgaaaataga agccattgct   2760

cagcaccgtt tctccatcaa tgccgtgaac ttgccttact tgaggaaaaa ttctttaact   2820

ttggaatatt gcattgaact cagctataca cataaaacat tttctttggt aaatcaagat   2880

ccagtcaggg tttctcttga attattttgg aacaatgcca ggatccaaac tgattaagtt   2940

acagtttaag cacccttcag tattaatata tacggtatta tataacaggt caacaagtgc   3000

tctttgatgt taaaacttgt aatagagcaa taattgtaaa tggttaccat actgtaagat   3060

attttgataa aaattaacta gtagtacttg tatttatttg aaacactggg ctgtttgcac   3120

agctccaact gtgcatgctc aaaatgtgca ctttttaaaa ttgttacttt taatgcgtat   3180

ctttatatgg gatctgttat agtatactag ggcatgatat ggtatccttt tgagtgaggt   3240

atatactcat ctcacaagtg aagtgcctac tgatattact aaagtacatt atgtttactc   3300

aagtaaataa ttttctcccc atggtacact ctagtgtagg ctattcatac cacactgaaa   3360

tgaacaactg aagaataagg ctaagaacca ataaaatatt tctctaattg ctagttgtaa   3420

aactgtatcc aaattttcag aaaagacagc ttcagcttgc aaattctatc ctctaaactt   3480

atctggtgca ttctccccac cccaccccca ttatataagg gctattttag atgcttttaa   3540

cctccccaac aaataatttg ccaagtgtcc aatgagaact tatcatgttg gtgtgttagg   3600

taaatcgggc aaatatgata gtgtcttaca ttgggccttg attttaagtt gttatatttg   3660

tacaatcgag tattttagaa attacatgaa acatgaaaca gtttttgcaa ttttttttta   3720

aactgggcat ctggtttcta aaaatttatt tgaaacaatc tagaattttc ttggtgcaaa   3780

gtgtatcatg tggaatatcc tcatattttt accatatttt aagaacttta agacgattaa   3840

ttgtaaataa tttatttgat tggtgcagtt ctaatcccta aatcataatc ttaaaatcag   3900

gaatgtgtgg agaacagagc catgtcatat cactttgctc ttaccattcc ttttgatcag   3960

cctcaattca gcctcattgt gtagtatgtt ttttctttct atgaaaaaca acagaaagca   4020

tttcatttta tttgcctatg ttcaaatatg tttaataatg accaaagtgc attctgagtt   4080

ttttcaagga atgtaatact ggagctttaa gaacatactt agtttctcat gtgaaaactt   4140

aggctttgtc tgatgttttt ccttcctcta ttgtctaatg ttgaggttgt ttttaggaat   4200

tatgttttat aaactttttc aatataaggt acatgcctat acagaactta acattttgca   4260

cagaatatat caaatatatt ttgagaaaaa aagtacggca tgagttctgt taggaataaa   4320

agatgaaact attgtatctc acaaaaaatc ttatttcaga atggaaatat ttttgagaaa   4380

agtagctgag catactggtt taagaaaatg cttgttttag attgaggtta acttagagtt   4440

gggagttgat ttattaagta cagtatacct ctcaacagtt tataaataat atgttgaatt   4500

atgtcagtgt gggcagcagt agaatactaa aaggaaaatg tcatgttaag caatttcaga   4560

acattaactg aactattttc aaagcagaaa aattgacatt gctgccttta agaataccat   4620

gaatgtaaga aattgaaaga aattgtaaaa tatcacataa tatagaaatg gcagttcaaa   4680

gagaattgtg gcagatgttg tgtgtgaact gttgtttctt tgccacatgt gttgtatttg   4740

aaagttttac agtaagttta aaataaaaca ttctgtgacc aaaaaaaaaa aaaaaaaaaa   4800

aa                                                                  4802


<210>  2032
<211>  785
<212>  PRT
<213>  Homosapiens

<400>  2032

Met Ala Pro Lys Val Thr Asp Ala Ile Val Trp Tyr Gln Lys Lys Glu 
1               5                   10                  15      


Phe Leu Ser Val Ala Thr Thr Ala Pro Gly Pro Gln Gln Val Leu Pro 
            20                  25                  30          


Gly Tyr Cys Gln Cys Ser Leu Lys Asp Gln Gly Leu Phe Ile Gln Cys 
        35                  40                  45              


Leu Ile Gly Ala Tyr Asp Gln Gln Ile Trp Glu Lys Ser Val Glu Gln 
    50                  55                  60                  


Arg Glu Ile Lys Phe Ile Lys Leu Gly Leu Arg Asn Lys Pro Lys Lys 
65                  70                  75                  80  


Thr Ala His Val Lys Pro Asp Leu Ile Asp Val Asp Leu Val Arg Gly 
                85                  90                  95      


Ser Ala Phe Ala Lys Ala Lys Pro Glu Ser Pro Trp Thr Ser Leu Thr 
            100                 105                 110         


Arg Lys Gly Ile Val Arg Val Val Phe Phe Pro Phe Phe Phe Arg Trp 
        115                 120                 125             


Trp Leu Gln Val Thr Ser Lys Val Ile Phe Phe Trp Leu Leu Val Leu 
    130                 135                 140                 


Tyr Leu Leu Gln Val Ala Ala Ile Val Leu Phe Cys Ser Thr Ser Ser 
145                 150                 155                 160 


Pro His Ser Ile Pro Leu Thr Glu Val Ile Gly Pro Ile Trp Leu Met 
                165                 170                 175     


Leu Leu Leu Gly Thr Val His Cys Gln Ile Val Ser Thr Arg Thr Pro 
            180                 185                 190         


Lys Pro Pro Leu Ser Thr Gly Gly Lys Arg Arg Arg Lys Leu Arg Lys 
        195                 200                 205             


Ala Ala His Leu Glu Val His Arg Glu Gly Asp Gly Ser Ser Thr Thr 
    210                 215                 220                 


Asp Asn Thr Gln Glu Gly Ala Val Gln Asn His Gly Thr Ser Thr Ser 
225                 230                 235                 240 


His Ser Val Gly Thr Val Phe Arg Asp Leu Trp His Ala Ala Phe Phe 
                245                 250                 255     


Leu Ser Gly Ser Lys Lys Ala Lys Asn Ser Ile Asp Lys Ser Thr Glu 
            260                 265                 270         


Thr Asp Asn Gly Tyr Val Ser Leu Asp Gly Lys Lys Thr Val Lys Ser 
        275                 280                 285             


Gly Glu Asp Gly Ile Gln Asn His Glu Pro Gln Cys Glu Thr Ile Arg 
    290                 295                 300                 


Pro Glu Glu Thr Ala Trp Asn Thr Gly Thr Leu Arg Asn Gly Pro Ser 
305                 310                 315                 320 


Lys Asp Thr Gln Arg Thr Ile Thr Asn Val Ser Asp Glu Val Ser Ser 
                325                 330                 335     


Glu Glu Gly Pro Glu Thr Gly Tyr Ser Leu Arg Arg His Val Asp Arg 
            340                 345                 350         


Thr Ser Glu Gly Val Leu Arg Asn Arg Lys Ser His His Tyr Lys Lys 
        355                 360                 365             


His Tyr Pro Asn Glu Asp Ala Pro Lys Ser Gly Thr Ser Cys Ser Ser 
    370                 375                 380                 


Arg Cys Ser Ser Ser Arg Gln Asp Ser Glu Ser Ala Arg Pro Glu Ser 
385                 390                 395                 400 


Glu Thr Glu Asp Val Leu Trp Glu Asp Leu Leu His Cys Ala Glu Cys 
                405                 410                 415     


His Ser Ser Cys Thr Ser Glu Thr Asp Val Glu Asn His Gln Ile Asn 
            420                 425                 430         


Pro Cys Val Lys Lys Glu Tyr Arg Asp Asp Pro Phe His Gln Ser His 
        435                 440                 445             


Leu Pro Trp Leu His Ser Ser His Pro Gly Leu Glu Lys Ile Ser Ala 
    450                 455                 460                 


Ile Val Trp Glu Gly Asn Asp Cys Lys Lys Ala Asp Met Ser Val Leu 
465                 470                 475                 480 


Glu Ile Ser Gly Met Ile Met Asn Arg Val Asn Ser His Ile Pro Gly 
                485                 490                 495     


Ile Gly Tyr Gln Ile Phe Gly Asn Ala Val Ser Leu Ile Leu Gly Leu 
            500                 505                 510         


Thr Pro Phe Val Phe Arg Leu Ser Gln Ala Thr Asp Leu Glu Gln Leu 
        515                 520                 525             


Thr Ala His Ser Ala Ser Glu Leu Tyr Val Ile Ala Phe Gly Ser Asn 
    530                 535                 540                 


Glu Asp Val Ile Val Leu Ser Met Val Ile Ile Ser Phe Val Val Arg 
545                 550                 555                 560 


Val Ser Leu Val Trp Ile Phe Phe Phe Leu Leu Cys Val Ala Glu Arg 
                565                 570                 575     


Thr Tyr Lys Gln Arg Leu Leu Phe Ala Lys Leu Phe Gly His Leu Thr 
            580                 585                 590         


Ser Ala Arg Arg Ala Arg Lys Ser Glu Val Pro His Phe Arg Leu Lys 
        595                 600                 605             


Lys Val Gln Asn Ile Lys Met Trp Leu Ser Leu Arg Ser Tyr Leu Lys 
    610                 615                 620                 


Arg Arg Gly Pro Gln Arg Ser Val Asp Val Ile Val Ser Ser Ala Phe 
625                 630                 635                 640 


Leu Leu Thr Ile Ser Val Val Phe Ile Cys Cys Ala Gln Leu Leu His 
                645                 650                 655     


Val His Glu Ile Phe Leu Asp Cys His Tyr Asn Trp Glu Leu Val Ile 
            660                 665                 670         


Trp Cys Ile Ser Leu Thr Leu Phe Leu Leu Arg Phe Val Thr Leu Gly 
        675                 680                 685             


Ser Glu Thr Ser Lys Lys Tyr Ser Asn Thr Ser Ile Leu Leu Thr Glu 
    690                 695                 700                 


Gln Ile Asn Leu Tyr Leu Lys Met Glu Lys Lys Pro Asn Lys Lys Glu 
705                 710                 715                 720 


Glu Leu Thr Leu Val Asn Asn Val Leu Lys Leu Ala Thr Lys Leu Leu 
                725                 730                 735     


Lys Glu Leu Asp Ser Pro Phe Arg Leu Tyr Gly Leu Thr Met Asn Pro 
            740                 745                 750         


Leu Leu Tyr Asn Ile Thr Gln Val Val Ile Leu Ser Ala Val Ser Gly 
        755                 760                 765             


Val Ile Ser Asp Leu Leu Gly Phe Asn Leu Lys Leu Trp Lys Ile Lys 
    770                 775                 780                 


Ser 
785 


<210>  2033
<211>  6880
<212>  DNA
<213>  Homosapiens

<400>  2033
agccttgagt gtcattcaag ggacagcaca acctcatcca agctctccta cctctgccca     60

gccgtccctc tcatcctccc cattcctcgt ccacactcca tccaaagaag agggaaagca    120

ccgaatagag gggggcgaag gcaaagtctg ctgttcttcc ccctgggccc ccttgctcct    180

ccatcctcat tctctcacca ccagcccccc taaccccaag gagcccagga actgaggcga    240

ctcgccccac tgccatgtcc aaaagcttga aaaagaaaag ccactggact agcaaagtcc    300

atgagagtgt cattggcagg aacccggagg gccagctggg ctttgaactg aaggggggcg    360

ccgagaatgg acagttcccc tacctggggg aggtgaagcc cggcaaggtg gcctatgaga    420

gcggcagcaa attggtgtcg gaggagctgc tgctggaggt gaacgagacc cccgtggcgg    480

ggctcaccat cagggacgtg ctggccgtga tcaaacactg caaggacccc ctccggctca    540

agtgtgtcaa gcaaggagga attgttgata aagaccttcg tcactacctc aacttacgat    600

ttcaaaaggg ttctgtggac catgagcttc agcaaatcat tcgtgacaac ctctacctcc    660

gcacggtgcc atgcaccaca aggccacata aggagggtga ggtccctgga gtggattata    720

ttttcatcac tgttgaagat tttatggaat tggagaaaag tggtgctctc ctagaaagtg    780

ggacttatga agacaattac tacggtaccc caaagccgcc agcagaacca gcaccattat    840

tgttaaatgt aacagaccag atacttccag gagccactcc aagtgctgaa ggaaaacgga    900

agaggaataa atcagtgagc aacatggaga aagccagtat agagcctcct gaggaggaag    960

aggaagagag gcctgtggtc aatggaaatg gagtagtagt aacaccagaa tccagtgaac   1020

atgaagacaa aagtgcaggt gcctcagggg agatgccctc ccagccttat cctgcaccag   1080

tgtacagtca gcctgaggag ctgaaggagc agatggatga cacaaagcca actaaacctg   1140

aagacaatga ggaaccagac ccattgcctg ataactggga aatggcctat acagagaagg   1200

gcgaagtcta cttcattgac cataacacaa agacaacatc atggctggat ccacgacttg   1260

cgaaaaaggc taaacctcca gaagagtgca aagaaaatga gcttccatat ggctgggaaa   1320

aaatcgatga tcccatttat ggcacttatt atgttgacca cataaataga agaacacagt   1380

ttgaaaatcc tgtcctggaa gcaaaaagga agctacagca acataacatg ccccacacag   1440

aacttggaac aaagcccctg caggccccag gtttccgaga aaaaccactc ttcacccggg   1500

atgcatccca gttgaaggga acattcctca gcaccaccct aaaaaagagc aacatgggct   1560

ttggatttac catcattggt ggagacgagc ctgatgagtt tctgcaggtg aaaagtgtga   1620

ttccggatgg gcctgcagca caggatggaa aaatggaaac aggtgatgtc attgtctata   1680

ttaatgaagt ttgtgtcctt ggacacactc atgcagatgt tgtcaaactt ttccagtctg   1740

ttcctattgg tcagagtgtc aacctggtgt tgtgtcgtgg ctaccctttg ccctttgatc   1800

ctgaagaccc tgctaacagc atggtgccac cccttgcaat aatggagagg ccacctccag   1860

tgatggtcaa tggaagacac aactatgaaa catatttgga gtacatttct cggacctcac   1920

agtcagttcc agatataaca gatcggccgc ctcattctct gcactccatg ccaactgatg   1980

gtcagctaga cggcacgtat ccaccgcccg tccatgatga caatgtgtct atggcttcat   2040

ctggggccac ccaagctgaa cttatgacct taaccattgt gaaaggtgcc cagggcttcg   2100

gcttcactat tgccgacagt cctacaggac agcgggtgaa acaaatactt gacattcagg   2160

gatgccctgg cctgtgtgaa ggcgacctca ttgttgagat caaccagcag aatgtacaga   2220

acctgagcca tacagaagta gtggatatac ttaaggactg tcccattgga agtgaaactt   2280

ctttgattat ccatcgagga ggtttctttt ctccatggaa aactccaaag cctataatgg   2340

accgatggga gaatcaaggc agtcctcaaa cgagtttatc tgctccggcc ataccgcaga   2400

acctgccctt cccacctgcc cttcacagga gctcctttcc tgactcaaca gaggcctttg   2460

acccacggaa gcctgatcca tatgagctct acgagaaatc tagggccatt tatgaaagta   2520

ggcaacaagt gccacccagg accagttttc gaatggattc ctctggtcca gattataagg   2580

aattggatgt tcatcttcgg aggatggagt ctggatttgg cttcagaatc ctcgggggag   2640

atgagcctgg acagcctatt ttgattggag ctgtcattgc catgggctca gccgacagag   2700

atggccgcct tcacccagga gatgagcttg tgtatgttga tgggattcca gtagccggca   2760

aaacccaccg ctatgtcatc gacctcatgc accacgcagc ccgcaatggg caggtcaacc   2820

tcactgtgag aagaaaggtg ctatgtggag gggagccctg cccagagaac gggagaagtc   2880

caggctctgt atccacccac cacagctctc cacgcagtga ctacgcaacc tacaccaaca   2940

gcaaccacgc tgcccccagt agcaatgcct ctccccctga aggcttcgcc tcccacagcc   3000

tgcagaccag tgatgtggtc attcaccgca aagagaatga gggcttcggc tttgtcatca   3060

tcagctccct gaacaggcct gagtctggat ccactataac tgtgccccat aaaatcggac   3120

gcatcattga tgggagtcct gcagatcgct gtgcaaaact aaaagtggga gaccggatcc   3180

tagcagtgaa tggccagtct atcatcaaca tgcctcacgc tgacatcgtg aagctcatca   3240

aggatgcagg tcttagtgtc acccttcgca tcattcctca ggaggagctc aacagcccca   3300

cctcggcacc cagctcagag aagcagagtc ccatggcgca gcagagtccc ctggcacagc   3360

agagtcccct ggcccagcca agcccagcca cccccaacag ccccatcgcc cagccagcac   3420

cacctcaacc acttcagctg caaggacacg aaaatagtta caggtcggaa gtgaaagcaa   3480

ggcaagatgt gaaaccagac atccgacagc ctccattcac agactacagg cagcccccgc   3540

tggattacag gcaaccccca ggaggggact accagcagcc cccacccttg gactacaggc   3600

agcctcccct actggactac aggcagcact cccccgacac caggcagtac cctctgtcgg   3660

actacagaca accccaggat tttgattatt tcactgtgga catggagaaa ggagccaaag   3720

gatttggatt cagcattcgt ggaggaaggg aatacaaaat ggatttgtat gtgttgagac   3780

tggcagaaga tggaccagca ataaggaatg ggaggatgag ggtaggagat caaatcattg   3840

aaatcaatgg ggaaagcaca agggacatga cacatgccag agcaatagaa ctcatcaaat   3900

ctggaggaag acgagtgagg ctgctgctca agagaggcac gggacaggtc ccagaatatg   3960

acgaacccgc cccctggagt tctcccgctg ccgccgcccc aggtctgccg gaagtaggcg   4020

tctccctgga cgacggcctc gctccattct ctccatcaca tccagcccca ccctccgacc   4080

cttcccacca gataagccca ggcccaactt gggatatcaa acgggaacac gacgttagga   4140

aaccaaagga gctttcagcc tgcggccaga agaagcagcg cctcggggag cagagggagc   4200

gctcggcgag tccgcagagg gccgcgcggc cgaggctcga ggaggcgccc ggcggccagg   4260

ggcggcccga ggccggcagg cccgcctcgg aggccagggc gcccgggctc gcggcggcag   4320

acgcggcgga cgcggcgcgg gcgggcggga aggaggcgcc ccgtgcggcg gcgggctccg   4380

agctctgccg gcgcgaaggc ccgggggctg cgccggcgtt tgccggcccg ggcggcggcg   4440

gcagcggcgc gctggaggcc gagggcaggg cgggtgcgcg cgcgggtccc cggccgggcc   4500

cgcgaccccc ggggggcgcc ccggcgcgca aggccgccgt cgcgccgggg ccctggaagg   4560

tgccgggttc tgacaagctg cccagcgtcc tcaaacccgg cgcctcggcc gccagcagat   4620

gagccgcgcg gccacggcca acccgcccgc cccggcgcag gcagttcttc ttaggttccg   4680

tctcacggcg ttttaattta ttttcactgt cacacgcata gatccacgag gcaccaaggc   4740

ctgggagcat cgacgtgaag tcccacgtgt ccggtgtgct tgggcggcat cgcatcaacg   4800

cgcagaccta aactgatcct aaagcccccg gttcccttgt gggggctttg gcagctatgg   4860

aagaaccaaa ataacgtgaa gaacatcaca gagagacagt gcagtgtagc tttagtttaa   4920

gaaaaaaaaa tattcctccc cactgcatga aggacttgga tgtcatccaa actttatatc   4980

aagaaacagg acaaagttaa gagcaatcac aaactggaat atcgccttaa aaatcaaact   5040

gcacggagca agctgaaact gagacaagat tatatctttt aattgatcta aagcgttgta   5100

aataaattgt tctcgacata tctagacagg ggttaaaggg tttctttgac acattcggaa   5160

ccgttcaccc atgacatgtt tccatggctc acccttggca tccatcctcg gtgttagcag   5220

cagcgttccc tgcctcctgc aggatgactt agaaatctag tgagtttctt ggtgtgatgc   5280

catttttatt gccctttctg tgatcaaatc atatttctgt acattttcag tggtagaaaa   5340

aaaaggtttt aaaaattgta tcctagggaa cagtttgcca taagtcagaa ttttgcagtt   5400

tagctcatag atcttaattg gtttttctct aaaatatgaa ttttataatt gaaggaccac   5460

aatttgttta atcaagatag gcaacgctgc agttccttta tgaagaggct tttctgtcgt   5520

cccaggctag cagagatgga tagcttcttt gtcagcaatg tgatttcact tattttattg   5580

tcttatttta aaccctgtct ccatgacttc atttgcactt tgacagagca gaggcagagt   5640

atttgtctta tatttctcag attataatat taaaaaatta caatcaattt attttcatta   5700

aagaacgtga gtctttttag cattcctttc tgcttatcct tctttcctta ccctttgtcc   5760

ttttgtttcc attagttttc tttcgtcttg tattccttgc cactttattt tgttagcaac   5820

ttctagatgt ttatcttcat ggatctatga ttgacctcct agtaaaattc taagtcttgc   5880

ctttcttccc tgctgtttta gcatttcttt gtaaaatgtt agcttcaatt aattagccat   5940

tggtacttac tgtagctaca catattaaaa ggcaaagtgt ttctgaaggc aatttctttt   6000

taatatgccc gaatgaatga ggcttcatcc tttccatatt cttactcttt acaggagttc   6060

aaatgcaaat aagctccacc tccctgcact tgtagtctaa aaagtaaaag gggcgatcag   6120

gtccatctca aaggtcacac gtaatagcct ccctgggctg atcattccct ctccttgtaa   6180

ttgcagtatc ctgagtagca gtttaatttt catcaaacat cggagtagtt tagttgtttg   6240

acaggaggag aataaggctg aaagcctcaa gtgaaggatc ttgcagcttg taaaagcaat   6300

ttccaaaaat gaaacccatt catcgtaaac aaaagcacaa acacttgtag cagtttataa   6360

tgcttttggt ttaatctcaa ttagtctttc tcccctggac tagaaatcca gtatagtttg   6420

ccattaattt attgaatctg gttttggaca atgcttctgt agtgtagctg cacgtcctgg   6480

tactgtatcc tctgacttta ttttccatgt attacaaaag gaaaaaaaaa ttgagattac   6540

actggcataa actctagttt gcacagttca cagctactac ttgtgcagta attgctttat   6600

gcggctgtaa tccataacct gtgaagacag cacatcatct aaatcccatt ccaaataata   6660

tttgtgtagt gttagctgtg aatttaccct gtacagctgt atctctataa atataattcc   6720

atgtattaat agtcacagaa agactgtaag tgagcaacta tttttatgaa acgtaccact   6780

atggataaat taacttttac agaaatcttg tttactgtat gatattctaa aacactgtca   6840

aataaaatat atatccaaaa atcttttctt tttccaacta                         6880


<210>  2034
<211>  1455
<212>  PRT
<213>  Homosapiens

<400>  2034

Met Ser Lys Ser Leu Lys Lys Lys Ser His Trp Thr Ser Lys Val His 
1               5                   10                  15      


Glu Ser Val Ile Gly Arg Asn Pro Glu Gly Gln Leu Gly Phe Glu Leu 
            20                  25                  30          


Lys Gly Gly Ala Glu Asn Gly Gln Phe Pro Tyr Leu Gly Glu Val Lys 
        35                  40                  45              


Pro Gly Lys Val Ala Tyr Glu Ser Gly Ser Lys Leu Val Ser Glu Glu 
    50                  55                  60                  


Leu Leu Leu Glu Val Asn Glu Thr Pro Val Ala Gly Leu Thr Ile Arg 
65                  70                  75                  80  


Asp Val Leu Ala Val Ile Lys His Cys Lys Asp Pro Leu Arg Leu Lys 
                85                  90                  95      


Cys Val Lys Gln Gly Gly Ile Val Asp Lys Asp Leu Arg His Tyr Leu 
            100                 105                 110         


Asn Leu Arg Phe Gln Lys Gly Ser Val Asp His Glu Leu Gln Gln Ile 
        115                 120                 125             


Ile Arg Asp Asn Leu Tyr Leu Arg Thr Val Pro Cys Thr Thr Arg Pro 
    130                 135                 140                 


His Lys Glu Gly Glu Val Pro Gly Val Asp Tyr Ile Phe Ile Thr Val 
145                 150                 155                 160 


Glu Asp Phe Met Glu Leu Glu Lys Ser Gly Ala Leu Leu Glu Ser Gly 
                165                 170                 175     


Thr Tyr Glu Asp Asn Tyr Tyr Gly Thr Pro Lys Pro Pro Ala Glu Pro 
            180                 185                 190         


Ala Pro Leu Leu Leu Asn Val Thr Asp Gln Ile Leu Pro Gly Ala Thr 
        195                 200                 205             


Pro Ser Ala Glu Gly Lys Arg Lys Arg Asn Lys Ser Val Ser Asn Met 
    210                 215                 220                 


Glu Lys Ala Ser Ile Glu Pro Pro Glu Glu Glu Glu Glu Glu Arg Pro 
225                 230                 235                 240 


Val Val Asn Gly Asn Gly Val Val Val Thr Pro Glu Ser Ser Glu His 
                245                 250                 255     


Glu Asp Lys Ser Ala Gly Ala Ser Gly Glu Met Pro Ser Gln Pro Tyr 
            260                 265                 270         


Pro Ala Pro Val Tyr Ser Gln Pro Glu Glu Leu Lys Glu Gln Met Asp 
        275                 280                 285             


Asp Thr Lys Pro Thr Lys Pro Glu Asp Asn Glu Glu Pro Asp Pro Leu 
    290                 295                 300                 


Pro Asp Asn Trp Glu Met Ala Tyr Thr Glu Lys Gly Glu Val Tyr Phe 
305                 310                 315                 320 


Ile Asp His Asn Thr Lys Thr Thr Ser Trp Leu Asp Pro Arg Leu Ala 
                325                 330                 335     


Lys Lys Ala Lys Pro Pro Glu Glu Cys Lys Glu Asn Glu Leu Pro Tyr 
            340                 345                 350         


Gly Trp Glu Lys Ile Asp Asp Pro Ile Tyr Gly Thr Tyr Tyr Val Asp 
        355                 360                 365             


His Ile Asn Arg Arg Thr Gln Phe Glu Asn Pro Val Leu Glu Ala Lys 
    370                 375                 380                 


Arg Lys Leu Gln Gln His Asn Met Pro His Thr Glu Leu Gly Thr Lys 
385                 390                 395                 400 


Pro Leu Gln Ala Pro Gly Phe Arg Glu Lys Pro Leu Phe Thr Arg Asp 
                405                 410                 415     


Ala Ser Gln Leu Lys Gly Thr Phe Leu Ser Thr Thr Leu Lys Lys Ser 
            420                 425                 430         


Asn Met Gly Phe Gly Phe Thr Ile Ile Gly Gly Asp Glu Pro Asp Glu 
        435                 440                 445             


Phe Leu Gln Val Lys Ser Val Ile Pro Asp Gly Pro Ala Ala Gln Asp 
    450                 455                 460                 


Gly Lys Met Glu Thr Gly Asp Val Ile Val Tyr Ile Asn Glu Val Cys 
465                 470                 475                 480 


Val Leu Gly His Thr His Ala Asp Val Val Lys Leu Phe Gln Ser Val 
                485                 490                 495     


Pro Ile Gly Gln Ser Val Asn Leu Val Leu Cys Arg Gly Tyr Pro Leu 
            500                 505                 510         


Pro Phe Asp Pro Glu Asp Pro Ala Asn Ser Met Val Pro Pro Leu Ala 
        515                 520                 525             


Ile Met Glu Arg Pro Pro Pro Val Met Val Asn Gly Arg His Asn Tyr 
    530                 535                 540                 


Glu Thr Tyr Leu Glu Tyr Ile Ser Arg Thr Ser Gln Ser Val Pro Asp 
545                 550                 555                 560 


Ile Thr Asp Arg Pro Pro His Ser Leu His Ser Met Pro Thr Asp Gly 
                565                 570                 575     


Gln Leu Asp Gly Thr Tyr Pro Pro Pro Val His Asp Asp Asn Val Ser 
            580                 585                 590         


Met Ala Ser Ser Gly Ala Thr Gln Ala Glu Leu Met Thr Leu Thr Ile 
        595                 600                 605             


Val Lys Gly Ala Gln Gly Phe Gly Phe Thr Ile Ala Asp Ser Pro Thr 
    610                 615                 620                 


Gly Gln Arg Val Lys Gln Ile Leu Asp Ile Gln Gly Cys Pro Gly Leu 
625                 630                 635                 640 


Cys Glu Gly Asp Leu Ile Val Glu Ile Asn Gln Gln Asn Val Gln Asn 
                645                 650                 655     


Leu Ser His Thr Glu Val Val Asp Ile Leu Lys Asp Cys Pro Ile Gly 
            660                 665                 670         


Ser Glu Thr Ser Leu Ile Ile His Arg Gly Gly Phe Phe Ser Pro Trp 
        675                 680                 685             


Lys Thr Pro Lys Pro Ile Met Asp Arg Trp Glu Asn Gln Gly Ser Pro 
    690                 695                 700                 


Gln Thr Ser Leu Ser Ala Pro Ala Ile Pro Gln Asn Leu Pro Phe Pro 
705                 710                 715                 720 


Pro Ala Leu His Arg Ser Ser Phe Pro Asp Ser Thr Glu Ala Phe Asp 
                725                 730                 735     


Pro Arg Lys Pro Asp Pro Tyr Glu Leu Tyr Glu Lys Ser Arg Ala Ile 
            740                 745                 750         


Tyr Glu Ser Arg Gln Gln Val Pro Pro Arg Thr Ser Phe Arg Met Asp 
        755                 760                 765             


Ser Ser Gly Pro Asp Tyr Lys Glu Leu Asp Val His Leu Arg Arg Met 
    770                 775                 780                 


Glu Ser Gly Phe Gly Phe Arg Ile Leu Gly Gly Asp Glu Pro Gly Gln 
785                 790                 795                 800 


Pro Ile Leu Ile Gly Ala Val Ile Ala Met Gly Ser Ala Asp Arg Asp 
                805                 810                 815     


Gly Arg Leu His Pro Gly Asp Glu Leu Val Tyr Val Asp Gly Ile Pro 
            820                 825                 830         


Val Ala Gly Lys Thr His Arg Tyr Val Ile Asp Leu Met His His Ala 
        835                 840                 845             


Ala Arg Asn Gly Gln Val Asn Leu Thr Val Arg Arg Lys Val Leu Cys 
    850                 855                 860                 


Gly Gly Glu Pro Cys Pro Glu Asn Gly Arg Ser Pro Gly Ser Val Ser 
865                 870                 875                 880 


Thr His His Ser Ser Pro Arg Ser Asp Tyr Ala Thr Tyr Thr Asn Ser 
                885                 890                 895     


Asn His Ala Ala Pro Ser Ser Asn Ala Ser Pro Pro Glu Gly Phe Ala 
            900                 905                 910         


Ser His Ser Leu Gln Thr Ser Asp Val Val Ile His Arg Lys Glu Asn 
        915                 920                 925             


Glu Gly Phe Gly Phe Val Ile Ile Ser Ser Leu Asn Arg Pro Glu Ser 
    930                 935                 940                 


Gly Ser Thr Ile Thr Val Pro His Lys Ile Gly Arg Ile Ile Asp Gly 
945                 950                 955                 960 


Ser Pro Ala Asp Arg Cys Ala Lys Leu Lys Val Gly Asp Arg Ile Leu 
                965                 970                 975     


Ala Val Asn Gly Gln Ser Ile Ile Asn Met Pro His Ala Asp Ile Val 
            980                 985                 990         


Lys Leu Ile Lys Asp Ala Gly Leu  Ser Val Thr Leu Arg  Ile Ile Pro 
        995                 1000                 1005             


Gln Glu  Glu Leu Asn Ser Pro  Thr Ser Ala Pro Ser  Ser Glu Lys 
    1010                 1015                 1020             


Gln Ser  Pro Met Ala Gln Gln  Ser Pro Leu Ala Gln  Gln Ser Pro 
    1025                 1030                 1035             


Leu Ala  Gln Pro Ser Pro Ala  Thr Pro Asn Ser Pro  Ile Ala Gln 
    1040                 1045                 1050             


Pro Ala  Pro Pro Gln Pro Leu  Gln Leu Gln Gly His  Glu Asn Ser 
    1055                 1060                 1065             


Tyr Arg  Ser Glu Val Lys Ala  Arg Gln Asp Val Lys  Pro Asp Ile 
    1070                 1075                 1080             


Arg Gln  Pro Pro Phe Thr Asp  Tyr Arg Gln Pro Pro  Leu Asp Tyr 
    1085                 1090                 1095             


Arg Gln  Pro Pro Gly Gly Asp  Tyr Gln Gln Pro Pro  Pro Leu Asp 
    1100                 1105                 1110             


Tyr Arg  Gln Pro Pro Leu Leu  Asp Tyr Arg Gln His  Ser Pro Asp 
    1115                 1120                 1125             


Thr Arg  Gln Tyr Pro Leu Ser  Asp Tyr Arg Gln Pro  Gln Asp Phe 
    1130                 1135                 1140             


Asp Tyr  Phe Thr Val Asp Met  Glu Lys Gly Ala Lys  Gly Phe Gly 
    1145                 1150                 1155             


Phe Ser  Ile Arg Gly Gly Arg  Glu Tyr Lys Met Asp  Leu Tyr Val 
    1160                 1165                 1170             


Leu Arg  Leu Ala Glu Asp Gly  Pro Ala Ile Arg Asn  Gly Arg Met 
    1175                 1180                 1185             


Arg Val  Gly Asp Gln Ile Ile  Glu Ile Asn Gly Glu  Ser Thr Arg 
    1190                 1195                 1200             


Asp Met  Thr His Ala Arg Ala  Ile Glu Leu Ile Lys  Ser Gly Gly 
    1205                 1210                 1215             


Arg Arg  Val Arg Leu Leu Leu  Lys Arg Gly Thr Gly  Gln Val Pro 
    1220                 1225                 1230             


Glu Tyr  Asp Glu Pro Ala Pro  Trp Ser Ser Pro Ala  Ala Ala Ala 
    1235                 1240                 1245             


Pro Gly  Leu Pro Glu Val Gly  Val Ser Leu Asp Asp  Gly Leu Ala 
    1250                 1255                 1260             


Pro Phe  Ser Pro Ser His Pro  Ala Pro Pro Ser Asp  Pro Ser His 
    1265                 1270                 1275             


Gln Ile  Ser Pro Gly Pro Thr  Trp Asp Ile Lys Arg  Glu His Asp 
    1280                 1285                 1290             


Val Arg  Lys Pro Lys Glu Leu  Ser Ala Cys Gly Gln  Lys Lys Gln 
    1295                 1300                 1305             


Arg Leu  Gly Glu Gln Arg Glu  Arg Ser Ala Ser Pro  Gln Arg Ala 
    1310                 1315                 1320             


Ala Arg  Pro Arg Leu Glu Glu  Ala Pro Gly Gly Gln  Gly Arg Pro 
    1325                 1330                 1335             


Glu Ala  Gly Arg Pro Ala Ser  Glu Ala Arg Ala Pro  Gly Leu Ala 
    1340                 1345                 1350             


Ala Ala  Asp Ala Ala Asp Ala  Ala Arg Ala Gly Gly  Lys Glu Ala 
    1355                 1360                 1365             


Pro Arg  Ala Ala Ala Gly Ser  Glu Leu Cys Arg Arg  Glu Gly Pro 
    1370                 1375                 1380             


Gly Ala  Ala Pro Ala Phe Ala  Gly Pro Gly Gly Gly  Gly Ser Gly 
    1385                 1390                 1395             


Ala Leu  Glu Ala Glu Gly Arg  Ala Gly Ala Arg Ala  Gly Pro Arg 
    1400                 1405                 1410             


Pro Gly  Pro Arg Pro Pro Gly  Gly Ala Pro Ala Arg  Lys Ala Ala 
    1415                 1420                 1425             


Val Ala  Pro Gly Pro Trp Lys  Val Pro Gly Ser Asp  Lys Leu Pro 
    1430                 1435                 1440             


Ser Val  Leu Lys Pro Gly Ala  Ser Ala Ala Ser Arg  
    1445                 1450                 1455 


<210>  2035
<211>  2820
<212>  DNA
<213>  Homosapiens

<400>  2035
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa     60

aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc    120

caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa    180

ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc    240

atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca    300

gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat    360

actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag    420

gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca    480

agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt    540

agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt    600

ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagctt tttgccttcg    660

agctatcggg gtaaagacct acaggaaaac tactgtcgaa atcctcgagg ggaagaaggg    720

ggaccctggt gtttcacaag caatccagag gtacgctacg aagtctgtga cattcctcag    780

tgttcagaag ttgaatgcat gacctgcaat ggggagagtt atcgaggtct catggatcat    840

acagaatcag gcaagatttg tcagcgctgg gatcatcaga caccacaccg gcacaaattc    900

ttgcctgaaa gatatcccga caagggcttt gatgataatt attgccgcaa tcccgatggc    960

cagccgaggc catggtgcta tactcttgac cctcacaccc gctgggagta ctgtgcaatt   1020

aaaacatgcg ctgacaatac tatgaatgac actgatgttc ctttggaaac aactgaatgc   1080

atccaaggtc aaggagaagg ctacaggggc actgtcaata ccatttggaa tggaattcca   1140

tgtcagcgtt gggattctca gtatcctcac gagcatgaca tgactcctga aaatttcaag   1200

tgcaaggacc tacgagaaaa ttactgccga aatccagatg ggtctgaatc accctggtgt   1260

tttaccactg atccaaacat ccgagttggc tactgctccc aaattccaaa ctgtgatatg   1320

tcacatggac aagattgtta tcgtgggaat ggcaaaaatt atatgggcaa cttatcccaa   1380

acaagatctg gactaacatg ttcaatgtgg gacaagaaca tggaagactt acatcgtcat   1440

atcttctggg aaccagatgc aagtaagctg aatgagaatt actgccgaaa tccagatgat   1500

gatgctcatg gaccctggtg ctacacggga aatccactca ttccttggga ttattgccct   1560

atttctcgtt gtgaaggtga taccacacct acaatagtca atttagacca tcccgtaata   1620

tcttgtgcca aaacgaaaca attgcgagtt gtaaatggga ttccaacacg aacaaacata   1680

ggatggatgg ttagtttgag atacagaaat aaacatatct gcggaggatc attgataaag   1740

gagagttggg ttcttactgc acgacagtgt ttcccttctc gagacttgaa agattatgaa   1800

gcttggcttg gaattcatga tgtccacgga agaggagatg agaaatgcaa acaggttctc   1860

aatgtttccc agctggtata tggccctgaa ggatcagatc tggttttaat gaagcttgcc   1920

aggcctgctg tcctggatga ttttgttagt acgattgatt tacctaatta tggatgcaca   1980

attcctgaaa agaccagttg cagtgtttat ggctggggct acactggatt gatcaactat   2040

gatggcctat tacgagtggc acatctctat ataatgggaa atgagaaatg cagccagcat   2100

catcgaggga aggtgactct gaatgagtct gaaatatgtg ctggggctga aaagattgga   2160

tcaggaccat gtgaggggga ttatggtggc ccacttgttt gtgagcaaca taaaatgaga   2220

atggttcttg gtgtcattgt tcctggtcgt ggatgtgcca ttccaaatcg tcctggtatt   2280

tttgtccgag tagcatatta tgcaaaatgg atacacaaaa ttattttaac atataaggta   2340

ccacagtcat agctgaagta agtgtgtctg aagcacccac caatacaact gtcttttaca   2400

tgaagatttc agagaatgtg gaatttaaaa tgtcacttac aacaatccta agacaactac   2460

tggagagtca tgtttgttga aattctcatt aatgtttatg ggtgttttct gttgttttgt   2520

ttgtcagtgt tattttgtca atgttgaagt gaattaaggt acatgcaagt gtaataacat   2580

atctcctgaa gatacttgaa tggattaaaa aaacacacag gtatatttgc tggatgataa   2640

agatttcatg ggaaaaaaaa tcaattaatc tgtctaagct gctttctgat gttggtttct   2700

taataatgag taaaccacaa attaaatgtt attttaacct caccaaaaca atttatacct   2760

tgtgtcccta aattgtagcc ctatattaaa ttatattaca tttcaaaaaa aaaaaaaaaa   2820


<210>  2036
<211>  728
<212>  PRT
<213>  Homosapiens

<400>  2036

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                 330                 335     


His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                 375                 380                 


Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                 535                 540                 


Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                 550                 555                 560 


Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                 570                 575     


Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                 585                 590         


Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                 600                 605             


Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                 615                 620                 


Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                 630                 635                 640 


Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                 650                 655     


Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                 665                 670         


Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                 680                 685             


Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                 695                 700                 


Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Tyr Lys Val Pro Gln Ser 
                725             


<210>  2037
<211>  1307
<212>  DNA
<213>  Homosapiens

<400>  2037
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa     60

aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc    120

caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa    180

ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc    240

atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca    300

gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat    360

actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag    420

gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca    480

agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt    540

agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt    600

ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagctt tttgccttcg    660

agctatcggg gtaaagacct acaggaaaac tactgtcgaa atcctcgagg ggaagaaggg    720

ggaccctggt gtttcacaag caatccagag gtacgctacg aagtctgtga cattcctcag    780

tgttcagaag ttgaatgcat gacctgcaat ggggagagtt atcgaggtct catggatcat    840

acagaatcag gcaagatttg tcagcgctgg gatcatcaga caccacaccg gcacaaattc    900

ttgcctgaaa gatatcccga caagggcttt gatgataatt attgccgcaa tcccgatggc    960

cagccgaggc catggtgcta tactcttgac cctcacaccc gctgggagta ctgtgcaatt   1020

aaaacatgcg agacataaca tgggctctca actgatggtg aacttcttct ggtgagtgac   1080

agaggctgca gtgaagaata atgagtctaa tagaagttta tcacagatgt ctctaatctt   1140

tatagctgat ccctacctct ctcgctgtct ttgtacccag cctgcattct gtttcgatct   1200

gtcttttagc agtccataca atcatttttc tacatgctgg cccttaccta gcttttctga   1260

atttacaata aaaactattt tttaacgtga aaaaaaaaaa aaaaaaa                 1307


<210>  2038
<211>  290
<212>  PRT
<213>  Homosapiens

<400>  2038

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Glu Thr 
    290 


<210>  2039
<211>  2805
<212>  DNA
<213>  Homosapiens

<400>  2039
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa     60

aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc    120

caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa    180

ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc    240

atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca    300

gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat    360

actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag    420

gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca    480

agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt    540

agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt    600

ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagcta tcggggtaaa    660

gacctacagg aaaactactg tcgaaatcct cgaggggaag aagggggacc ctggtgtttc    720

acaagcaatc cagaggtacg ctacgaagtc tgtgacattc ctcagtgttc agaagttgaa    780

tgcatgacct gcaatgggga gagttatcga ggtctcatgg atcatacaga atcaggcaag    840

atttgtcagc gctgggatca tcagacacca caccggcaca aattcttgcc tgaaagatat    900

cccgacaagg gctttgatga taattattgc cgcaatcccg atggccagcc gaggccatgg    960

tgctatactc ttgaccctca cacccgctgg gagtactgtg caattaaaac atgcgctgac   1020

aatactatga atgacactga tgttcctttg gaaacaactg aatgcatcca aggtcaagga   1080

gaaggctaca ggggcactgt caataccatt tggaatggaa ttccatgtca gcgttgggat   1140

tctcagtatc ctcacgagca tgacatgact cctgaaaatt tcaagtgcaa ggacctacga   1200

gaaaattact gccgaaatcc agatgggtct gaatcaccct ggtgttttac cactgatcca   1260

aacatccgag ttggctactg ctcccaaatt ccaaactgtg atatgtcaca tggacaagat   1320

tgttatcgtg ggaatggcaa aaattatatg ggcaacttat cccaaacaag atctggacta   1380

acatgttcaa tgtgggacaa gaacatggaa gacttacatc gtcatatctt ctgggaacca   1440

gatgcaagta agctgaatga gaattactgc cgaaatccag atgatgatgc tcatggaccc   1500

tggtgctaca cgggaaatcc actcattcct tgggattatt gccctatttc tcgttgtgaa   1560

ggtgatacca cacctacaat agtcaattta gaccatcccg taatatcttg tgccaaaacg   1620

aaacaattgc gagttgtaaa tgggattcca acacgaacaa acataggatg gatggttagt   1680

ttgagataca gaaataaaca tatctgcgga ggatcattga taaaggagag ttgggttctt   1740

actgcacgac agtgtttccc ttctcgagac ttgaaagatt atgaagcttg gcttggaatt   1800

catgatgtcc acggaagagg agatgagaaa tgcaaacagg ttctcaatgt ttcccagctg   1860

gtatatggcc ctgaaggatc agatctggtt ttaatgaagc ttgccaggcc tgctgtcctg   1920

gatgattttg ttagtacgat tgatttacct aattatggat gcacaattcc tgaaaagacc   1980

agttgcagtg tttatggctg gggctacact ggattgatca actatgatgg cctattacga   2040

gtggcacatc tctatataat gggaaatgag aaatgcagcc agcatcatcg agggaaggtg   2100

actctgaatg agtctgaaat atgtgctggg gctgaaaaga ttggatcagg accatgtgag   2160

ggggattatg gtggcccact tgtttgtgag caacataaaa tgagaatggt tcttggtgtc   2220

attgttcctg gtcgtggatg tgccattcca aatcgtcctg gtatttttgt ccgagtagca   2280

tattatgcaa aatggataca caaaattatt ttaacatata aggtaccaca gtcatagctg   2340

aagtaagtgt gtctgaagca cccaccaata caactgtctt ttacatgaag atttcagaga   2400

atgtggaatt taaaatgtca cttacaacaa tcctaagaca actactggag agtcatgttt   2460

gttgaaattc tcattaatgt ttatgggtgt tttctgttgt tttgtttgtc agtgttattt   2520

tgtcaatgtt gaagtgaatt aaggtacatg caagtgtaat aacatatctc ctgaagatac   2580

ttgaatggat taaaaaaaca cacaggtata tttgctggat gataaagatt tcatgggaaa   2640

aaaaatcaat taatctgtct aagctgcttt ctgatgttgg tttcttaata atgagtaaac   2700

cacaaattaa atgttatttt aacctcacca aaacaattta taccttgtgt ccctaaattg   2760

tagccctata ttaaattata ttacatttca aaaaaaaaaa aaaaa                   2805


<210>  2040
<211>  723
<212>  PRT
<213>  Homosapiens

<400>  2040

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr Cys Arg Asn Pro Arg 
                165                 170                 175     


Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser Asn Pro Glu Val Arg 
            180                 185                 190         


Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu Val Glu Cys Met Thr 
        195                 200                 205             


Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp His Thr Glu Ser Gly 
    210                 215                 220                 


Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro His Arg His Lys Phe 
225                 230                 235                 240 


Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp Asp Asn Tyr Cys Arg 
                245                 250                 255     


Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr Thr Leu Asp Pro His 
            260                 265                 270         


Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys Ala Asp Asn Thr Met 
        275                 280                 285             


Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu Cys Ile Gln Gly Gln 
    290                 295                 300                 


Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile Trp Asn Gly Ile Pro 
305                 310                 315                 320 


Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu His Asp Met Thr Pro 
                325                 330                 335     


Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn Tyr Cys Arg Asn Pro 
            340                 345                 350         


Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr Asp Pro Asn Ile Arg 
        355                 360                 365             


Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp Met Ser His Gly Gln 
    370                 375                 380                 


Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met Gly Asn Leu Ser Gln 
385                 390                 395                 400 


Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp Lys Asn Met Glu Asp 
                405                 410                 415     


Leu His Arg His Ile Phe Trp Glu Pro Asp Ala Ser Lys Leu Asn Glu 
            420                 425                 430         


Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His Gly Pro Trp Cys Tyr 
        435                 440                 445             


Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys Pro Ile Ser Arg Cys 
    450                 455                 460                 


Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu Asp His Pro Val Ile 
465                 470                 475                 480 


Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val Asn Gly Ile Pro Thr 
                485                 490                 495     


Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg Tyr Arg Asn Lys His 
            500                 505                 510         


Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp Val Leu Thr Ala Arg 
        515                 520                 525             


Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr Glu Ala Trp Leu Gly 
    530                 535                 540                 


Ile His Asp Val His Gly Arg Gly Asp Glu Lys Cys Lys Gln Val Leu 
545                 550                 555                 560 


Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly Ser Asp Leu Val Leu 
                565                 570                 575     


Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp Phe Val Ser Thr Ile 
            580                 585                 590         


Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu Lys Thr Ser Cys Ser 
        595                 600                 605             


Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn Tyr Asp Gly Leu Leu 
    610                 615                 620                 


Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu Lys Cys Ser Gln His 
625                 630                 635                 640 


His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu Ile Cys Ala Gly Ala 
                645                 650                 655     


Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp Tyr Gly Gly Pro Leu 
            660                 665                 670         


Val Cys Glu Gln His Lys Met Arg Met Val Leu Gly Val Ile Val Pro 
        675                 680                 685             


Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly Ile Phe Val Arg Val 
    690                 695                 700                 


Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile Leu Thr Tyr Lys Val 
705                 710                 715                 720 


Pro Gln Ser 
            


<210>  2041
<211>  1292
<212>  DNA
<213>  Homosapiens

<400>  2041
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa     60

aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc    120

caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa    180

ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc    240

atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca    300

gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat    360

actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag    420

gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca    480

agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt    540

agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt    600

ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagcta tcggggtaaa    660

gacctacagg aaaactactg tcgaaatcct cgaggggaag aagggggacc ctggtgtttc    720

acaagcaatc cagaggtacg ctacgaagtc tgtgacattc ctcagtgttc agaagttgaa    780

tgcatgacct gcaatgggga gagttatcga ggtctcatgg atcatacaga atcaggcaag    840

atttgtcagc gctgggatca tcagacacca caccggcaca aattcttgcc tgaaagatat    900

cccgacaagg gctttgatga taattattgc cgcaatcccg atggccagcc gaggccatgg    960

tgctatactc ttgaccctca cacccgctgg gagtactgtg caattaaaac atgcgagaca   1020

taacatgggc tctcaactga tggtgaactt cttctggtga gtgacagagg ctgcagtgaa   1080

gaataatgag tctaatagaa gtttatcaca gatgtctcta atctttatag ctgatcccta   1140

cctctctcgc tgtctttgta cccagcctgc attctgtttc gatctgtctt ttagcagtcc   1200

atacaatcat ttttctacat gctggccctt acctagcttt tctgaattta caataaaaac   1260

tattttttaa cgtgaaaaaa aaaaaaaaaa aa                                 1292


<210>  2042
<211>  285
<212>  PRT
<213>  Homosapiens

<400>  2042

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr Cys Arg Asn Pro Arg 
                165                 170                 175     


Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser Asn Pro Glu Val Arg 
            180                 185                 190         


Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu Val Glu Cys Met Thr 
        195                 200                 205             


Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp His Thr Glu Ser Gly 
    210                 215                 220                 


Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro His Arg His Lys Phe 
225                 230                 235                 240 


Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp Asp Asn Tyr Cys Arg 
                245                 250                 255     


Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr Thr Leu Asp Pro His 
            260                 265                 270         


Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys Glu Thr 
        275                 280                 285 


<210>  2043
<211>  2079
<212>  DNA
<213>  Homosapiens

<400>  2043
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa     60

aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc    120

caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa    180

ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc    240

atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca    300

gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat    360

actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag    420

gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca    480

agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt    540

agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt    600

ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagctt tttgccttcg    660

agctatcggg gtaaagacct acaggaaaac tactgtcgaa atcctcgagg ggaagaaggg    720

ggaccctggt gtttcacaag caatccagag gtacgctacg aagtctgtga cattcctcag    780

tgttcagaag gtaaataaac ctgaatgcca tgtgggccat tctattcccc ctatgtgtag    840

aactgtaact cacattaaag gttaacagca acgaatcaat cataacaaat atgttgttcg    900

tgcaaatgca actacaaata attatttaaa catttttata caatgttttt aaaactgttg    960

gattatcacc agattaatgc aaaataacag agcgagttat cagtttgaat ttcaacactg   1020

cctgagacat ccctctgggg aaagtgaaag agagggttta cttacctact gtcttgagct   1080

cacatacctc aaaatctact actgtgtggc acctgaaagg agttgaatga agcttagcct   1140

ttcattagca atgttaattc tattcaacca gcacctgctt ccacagaaat tctgtccaaa   1200

ctatcatgaa gtggtgtgac aagggtatat ggacccagaa gataatacaa tataagaagg   1260

gatcactgga agcttgaccc catgcacatt ttggtgaaaa tgtgcctaga atcaaatgtg   1320

acacgtaggc tggaactgag taccattcag aataggatct gaagagatca aagcaatgga   1380

gaccaccaaa ctgtcttgaa ggcatgtcta tggaccttaa gtccatgtct atgttttcag   1440

ctcttctcac agcataaaag ggcattgtcc ttacttttgc agtggaaaac tgaatggctg   1500

acaagatgga agagtaacca tttcagcatt gtatgtggtt tcatttttct tagttatctg   1560

gctactgaat agccggattt ttcagttctg tcagaaactc taaatttcca aaaatctaag   1620

tgaaacatgg atgaaactct gttagaaaat tgttaggatt ttggagtatt tggggagggg   1680

gactactgga atgctgtcca agttttatac taagatatct tacctgtttg ttattaacca   1740

aatattttta aaaatatttc ctccataaat attcatttaa tattaggttg atatttatca   1800

cataaaaagt aaaggctact gttagctaat tgtcacagag aaggatttgt tttctgttgt   1860

tagtgaattt gaaatccttg actttatgtg ctacagccag ttccatctct gtttgtaaat   1920

tcttactttc cattccatat catattctgt tccctataac ctcttcattg ttttcttttc   1980

ttttaaaaat aataaacttt tctatgatca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                          2079


<210>  2044
<211>  210
<212>  PRT
<213>  Homosapiens

<400>  2044

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Gly Lys 
    210 


<210>  2045
<211>  4953
<212>  DNA
<213>  Homosapiens

<400>  2045
gcatcccctt gattaaatgt ttttcctcct atgcaatcac cattagctgt ttggctccca     60

ttctgtattc ttctgaagca gccctgcatt gcaaatcaat atctttctga aaagacagtg    120

tgttgtgaat tgccttgaca gcatatgcac ggttactttg gctgcaatgc tgctgcagag    180

cccggttact ctgccttcgt gggaactcca cagatatgtg tcacaaagat gtctacacgg    240

aactgccagg gaatggactc agtgatcaaa cccctggaca caattcctga ggataaaaaa    300

gtcagagttc agaggacaca gagcactttt gacccatttg agaaaccagc taatcaagta    360

aagagggtgc attctgagaa caatgcttgc attaacttta agacctcctc cactggcaaa    420

gagtcaccta aagttaggcg gcactccagc cccagctcgc caacaagtcc caaatttgga    480

aaagctgact catatgaaaa gctggaaaaa ctaggggaag gatcttatgc tacagtatac    540

aaagggaaaa gcaaggtaaa tgggaagttg gtagctctga aggtgatcag gctgcaggaa    600

gaagaaggga cacctttcac agctatcagg gaagcttctc ttttaaaagg actaaaacat    660

gctaacatag tgctacttca tgacatcatc cataccaagg agacgctgac acttgtgttt    720

gaatatgtgc acactgattt atgtcagtac atggacaagc accctggggg gctgcatcca    780

gataatgtga agttgttttt atttcagttg ctgcgaggtc tgtcttacat ccaccagcgt    840

tatattttgc acagagacct gaaaccacag aaccttctga tcagtgacac gggggagtta    900

aagctggcag atttcggtct tgcaagagca aaatccgtcc ctagccacac atactccaac    960

gaagtggtta ccttgtggta cagacctcca gatgtccttc taggctcaac agaatattcc   1020

acctgccttg acatgtgggg agtaggttgc atctttgttg aaatgatcca aggagttgct   1080

gcttttccag gaatgaaaga cattcaggat caacttgaac gaatatttct ggttcttgga   1140

acaccaaatg aggacacatg gcctggagtt cattctttac cacattttaa gccagaacgc   1200

tttaccctgt acagctctaa aaaccttaga caagcatgga ataagctcag ctatgtgaac   1260

catgcagagg acctggcctc caagctccta caatgttccc caaagaacag actgtcggca   1320

caggctgcct tgagccacga gtattttagt gacctgccgc cacggctatg ggaactcacc   1380

gacatgtctt ctatttttac tgtcccaaat gtgagattgc aaccagaagc tggagaaagc   1440

atgcgggcct ttgggaaaaa caatagttat ggcaaaagtc tatcaaacag caagcactga   1500

caagcagcac attctcaaga gcacacagga ttaagttgtc atcattctgg gaagaaaaaa   1560

aaaacattaa tgaagaggcc aataatatga agggaatcat ggatcagttt tctttcgctc   1620

cctgtggtgg atttcactta caagaaaatt gaagctggca agaccctgtt ttctctgcaa   1680

tttatttaaa accttgcacg catttggata ccttgtgatt tccaagaact acgtgaagat   1740

taagctttgc ttactgatac atggcatgta ttcttttcag tcttttgtgt ttgattttgt   1800

ttgatttccc tctgcagcac agcgtctctg taaaggtttt tatgctttca ccagccatgt   1860

cttaaataca ttaagacaac acatttggtg ttcacacttc ttcagtaatg tctgaacttg   1920

aaagccacag agtggcataa aacaatgtgt gttttctttg agagcagtgc acattttgca   1980

accactagga aggaaatttt ctgctaaagc aaacccctgt tctctgactt gacaacttgg   2040

ccccggactg tggggcccca cctgttgctt accttttgag gtaattttgc aaatgtggtt   2100

tttttacttg gaaataactg cacatttata tataggatat tggactctgc ttagcatttt   2160

caagccacat agcatgactg ttttttgaat aggttggaat tgaaaaaaca attatcaaac   2220

gttaagaaca aagacaggga taaattgctt acatttcaac ctctagagat tgaggtaact   2280

ttttgtgtct gggtcttgtc aacatctaat ttttttccat ccattctgtt acactttgta   2340

ttttctaact ggagaaaaga gtgaggaaca gaatgtttta aatctggtgc aaaagaacta   2400

tatctgctgg atgagccttg aaagcagtct tggcctgtta gggcttacaa agtaaattac   2460

aaagtgatcc agttcaaagt ttgcttagtt acaacaaagc acctttaaaa aaaatacatt   2520

ttaaaaaaac attccaagcc aattggaaga catcattggg ttcttacttt aagacatctc   2580

ctggaataac tgttcaaatg caggttttag aaacaatgca ggaatcttgc tttaaagatg   2640

aaaaagggaa tgggccagct tcccttactc aaggagttga gggaccttgg aggatgaagg   2700

cgagtatgtg acactggaga aaagtggacc aggcatgtct tttgctttga tctggaggga   2760

gggctgcctg atgcaggccg gctcccagtg gggcaggcct cgctgcagaa tgcccagtag   2820

tactgcggcc aaggggacag ttaggagact tcatctaaag catgaaacct agctcctcta   2880

cacacaaatt cctatggaaa tacctttgtg tacagtgtct tacattttcc tattagtcag   2940

aaagaaggag agaatgagtg agtgcttgaa atgtgtcata ctgttttagg atcaagacta   3000

ggaattagga gccaggttga caaggacttt ttctgagagt tgggtgaggg taaagctttt   3060

ctataatcaa gctcaataca ccaaggaaac tggatccaga attcctaaac tttaaaatgg   3120

tactgtctgc ggagtggagt atggatggtt atgtcaaagt catagttcat cctatccaga   3180

tgtagcattc atggtaaact tttaagtgct aagcaaggaa ttatttactg attggtttta   3240

aagagagcag aaaacaccca agtgtagaat gtctactgtt tgctacctag aaatcttttc   3300

cattcctctt tcatacattc caacccactg gaagtcttta gaggtatttt gatttaaagt   3360

atacttaaat taggatttct taaagaaaac atagggagaa aactttacat gcaattaaaa   3420

atggactttc ctgtgatttg tttttaatca ttcatttgga gaagaggcat gacctttgta   3480

tttcactaag tttaaagcaa gagcaactga tgattaaatg ttgcttttta ataaggtttt   3540

taacttgaaa atttgaaaat atttaatgtt gaaagacttc aattagggct attagagtta   3600

tatctccctg tcgtaggcag cttcttcgga gaagtgaaat ataacattac tcagtggacg   3660

gagaagtctg ttttgttaca gagacatgcc tctcagaagg tcaggaggtt ttgagtacct   3720

atccttgcca cccatacagg aaatccaaag tttggtgtct ctctctctct gtctctttct   3780

ttctctttct ccccccaaac ccctctcact ccctccctcc ctctctcctt cccctatttg   3840

caatcatatt ctccctctgc ttcttttctc ttctgccctc cttgtgggca gtcatgaaaa   3900

tcaattcaga ctgtgttcat tagcagattt attattctat tgagaaagca ctggaatgtt   3960

ttgtgagatt atttttatat gaaggaatag cctgaactca aacagatggt aagaatagta   4020

caaacacctt agcacatcac tgcacacaca gtattctgaa aggagatttg acacttaatt   4080

cccattttct taaaataaca gttttgttga cttaaaaata tgagatacat aggatgtgaa   4140

aaaaaatgtt tgcagtactc agcaaaaaat agggtacata aagcagggtg gctgtccatc   4200

cactgattct ggggtgagaa gcgatttcta cctcgcaaga gtgactagaa agtttctagg   4260

agcacctcca ggcttgcaaa gaaagtgagg cctcttggta tcctttcctc agtgtgtata   4320

tgacagccag tataatcaat accctaggtt atgcgtctat atgatactca tctgtgaata   4380

ttattggttt tgtaatcttt gttatataag aggatgttta ggctgtatat actggggtag   4440

attattgcct gccccttata cataggaata tgctgcataa ttgcgcataa cttccatctc   4500

ccttactggc ttgtaggcag aggaaactgt atatgttact gccttgtact tttctcatac   4560

accaaaaaca caccaaaaaa atcaataaaa taagcaatct tctattctca ttccttttcc   4620

cacagcagca tattttagag gcacatacaa aacctacatt ctctagttgg gagtggattt   4680

ttaaagtttt ccttttatct tttatttttt tttgtatgat gcactgagat gtgtactttc   4740

taacagggga ttggtaccta agaaatgtgg tagcattatt cagaaaacta ttatactttc   4800

aaatgacaca tagtaaggag aatggaataa tacatgttgc atatttgtta ccagttgtaa   4860

tttgtctgta ttatgaaaga tgtaatggtt tgtcagctgt cactgttgtt ttcttgtaac   4920

atgatatgga ataaagtata gcagaatctc cgt                                4953


<210>  2046
<211>  451
<212>  PRT
<213>  Homosapiens

<400>  2046

Met His Gly Tyr Phe Gly Cys Asn Ala Ala Ala Glu Pro Gly Tyr Ser 
1               5                   10                  15      


Ala Phe Val Gly Thr Pro Gln Ile Cys Val Thr Lys Met Ser Thr Arg 
            20                  25                  30          


Asn Cys Gln Gly Met Asp Ser Val Ile Lys Pro Leu Asp Thr Ile Pro 
        35                  40                  45              


Glu Asp Lys Lys Val Arg Val Gln Arg Thr Gln Ser Thr Phe Asp Pro 
    50                  55                  60                  


Phe Glu Lys Pro Ala Asn Gln Val Lys Arg Val His Ser Glu Asn Asn 
65                  70                  75                  80  


Ala Cys Ile Asn Phe Lys Thr Ser Ser Thr Gly Lys Glu Ser Pro Lys 
                85                  90                  95      


Val Arg Arg His Ser Ser Pro Ser Ser Pro Thr Ser Pro Lys Phe Gly 
            100                 105                 110         


Lys Ala Asp Ser Tyr Glu Lys Leu Glu Lys Leu Gly Glu Gly Ser Tyr 
        115                 120                 125             


Ala Thr Val Tyr Lys Gly Lys Ser Lys Val Asn Gly Lys Leu Val Ala 
    130                 135                 140                 


Leu Lys Val Ile Arg Leu Gln Glu Glu Glu Gly Thr Pro Phe Thr Ala 
145                 150                 155                 160 


Ile Arg Glu Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn Ile Val 
                165                 170                 175     


Leu Leu His Asp Ile Ile His Thr Lys Glu Thr Leu Thr Leu Val Phe 
            180                 185                 190         


Glu Tyr Val His Thr Asp Leu Cys Gln Tyr Met Asp Lys His Pro Gly 
        195                 200                 205             


Gly Leu His Pro Asp Asn Val Lys Leu Phe Leu Phe Gln Leu Leu Arg 
    210                 215                 220                 


Gly Leu Ser Tyr Ile His Gln Arg Tyr Ile Leu His Arg Asp Leu Lys 
225                 230                 235                 240 


Pro Gln Asn Leu Leu Ile Ser Asp Thr Gly Glu Leu Lys Leu Ala Asp 
                245                 250                 255     


Phe Gly Leu Ala Arg Ala Lys Ser Val Pro Ser His Thr Tyr Ser Asn 
            260                 265                 270         


Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Leu Gly Ser 
        275                 280                 285             


Thr Glu Tyr Ser Thr Cys Leu Asp Met Trp Gly Val Gly Cys Ile Phe 
    290                 295                 300                 


Val Glu Met Ile Gln Gly Val Ala Ala Phe Pro Gly Met Lys Asp Ile 
305                 310                 315                 320 


Gln Asp Gln Leu Glu Arg Ile Phe Leu Val Leu Gly Thr Pro Asn Glu 
                325                 330                 335     


Asp Thr Trp Pro Gly Val His Ser Leu Pro His Phe Lys Pro Glu Arg 
            340                 345                 350         


Phe Thr Leu Tyr Ser Ser Lys Asn Leu Arg Gln Ala Trp Asn Lys Leu 
        355                 360                 365             


Ser Tyr Val Asn His Ala Glu Asp Leu Ala Ser Lys Leu Leu Gln Cys 
    370                 375                 380                 


Ser Pro Lys Asn Arg Leu Ser Ala Gln Ala Ala Leu Ser His Glu Tyr 
385                 390                 395                 400 


Phe Ser Asp Leu Pro Pro Arg Leu Trp Glu Leu Thr Asp Met Ser Ser 
                405                 410                 415     


Ile Phe Thr Val Pro Asn Val Arg Leu Gln Pro Glu Ala Gly Glu Ser 
            420                 425                 430         


Met Arg Ala Phe Gly Lys Asn Asn Ser Tyr Gly Lys Ser Leu Ser Asn 
        435                 440                 445             


Ser Lys His 
    450     


<210>  2047
<211>  2163
<212>  DNA
<213>  Homosapiens

<400>  2047
agaggcggaa gtaaaagcga actacagtgg atgggtgcag ttcaggagat agctgttctc     60

cagcctttct ggagggatgc agagcctttc cttaggacaa acaagcattt caaaaggttt    120

gaactaccta accattatgg caccaggaaa cctctggcat atgagaaata actttctctt    180

tggttcaaga tgttggatga ctcgattttc agcagaaaac atcttcaaat cagtttcatt    240

taggcttttt ggtgtgaagt gtcataatac agacagtgag cctttgaaaa atgaggacct    300

actgaaaaac ttacttacta tgggagtaga tattgacatg gcaaggaaac gacagcctgg    360

agtttttcat aggatgatta ccaatgagca ggacctgaag atgttccttc tttccaaagg    420

agctagcaaa gaagtgatcg ctagcatcat atcaagatat ccacgagcaa taacacgtac    480

tcccgagaat ctttcaaaac ggtgggatct gtggagaaag attgtgacat cagaccttga    540

aattgtaaat attttggaac gttctcctga atcctttttt cggtccaata acaacctaaa    600

cttagagaat aatataaagt tcctctactc agttggattg acccgtaaat gcctttgtcg    660

attgttgacc aatgcccctc gtaccttctc caatagtctt gatctgaata aacagatggt    720

tgaatttttg caggcagccg gtttgtcatt gggtcacaat gatcccgcag attttgtcag    780

aaagataatt tttaaaaacc cttttatctt aattcagagc accaagcggg tgaaagctaa    840

cattgaattc ttacggtcaa ctttcaattt gaacagtgag gaactgctgg ttctgatatg    900

tggtccagga gctgaaatcc tagacctttc caatgactat gccagaagaa gctacgcaaa    960

catcaaagag aagctgtttt ctcttggatg tactgaagaa gaggtacaga agtttgtctt   1020

aagctatcca gatgtgatct tcttggcaga gaaaaagttt aatgataaaa tagactgcct   1080

catggaagaa aacattagca tttcacaaat aatcgaaaat cctcgggttc tggattcaag   1140

cataagtact ttaaaaagtc gaatcaaaga attggtaaat gctggctgta acttgagtac   1200

tttaaacatc actcttctat cttggagtaa aaaaagatat gaagctaaat tgaaaaagtt   1260

aagcagattt gcctaaggat gccaatgttt ttaattctca ggaactgtga atatgttatg   1320

ccacattgca aaagaatttt gcagaagtga ttaatttaaa atgttattaa gggccttgag   1380

atggggagat tatcctgaat tactttggag ggcctaatat aattgtaggg atctttaaaa   1440

gttgaagagg gaggcaaaag aggaggtcag agtgatcctg tataagaaag acaactactt   1500

ttgaaggaag ttaaaaggtg gctttgaagg aggaagacac cttgagccaa ggaatgaagg   1560

gggcctgtaa aaaaagattg aaaaggcaag gaaacagatt ctccattaga gtccccagaa   1620

aggaatgcag ccttgctggc acctttttag cccagtgaga tcaatgtcaa acttctgacc   1680

cacagaacca taagatggta aatttgtgtt gttttaaacc actgagtcag tgataatttg   1740

ctgaagaagc aaatagatta acatagcaac taagtagatg attagttgca ttataggtga   1800

agtcaaaaat acagtccttt agtaaagtct ctatttcttc cttttataag agtaattata   1860

tttaaaaaat ctacctaccc ttctggaatt gctaatgtta gtgtttataa agtcttaaat   1920

gtgtgcataa aaaactaaat gtgaatataa aatctaaata aaggaatatg tttgcctaat   1980

atagtttaag gaaatgataa tcatttctgt gcattttgtt ggcatttcag ctaatattaa   2040

agagtaattt tcagaggcat tgacttaaaa aatggcaaat cagataatgt cggtattttc   2100

aagatacaat ctagctctga cataaactga aagacgtgag acaaattata tgaccttaat   2160

ttt                                                                 2163


<210>  2048
<211>  399
<212>  PRT
<213>  Homosapiens

<400>  2048

Met Gln Ser Leu Ser Leu Gly Gln Thr Ser Ile Ser Lys Gly Leu Asn 
1               5                   10                  15      


Tyr Leu Thr Ile Met Ala Pro Gly Asn Leu Trp His Met Arg Asn Asn 
            20                  25                  30          


Phe Leu Phe Gly Ser Arg Cys Trp Met Thr Arg Phe Ser Ala Glu Asn 
        35                  40                  45              


Ile Phe Lys Ser Val Ser Phe Arg Leu Phe Gly Val Lys Cys His Asn 
    50                  55                  60                  


Thr Asp Ser Glu Pro Leu Lys Asn Glu Asp Leu Leu Lys Asn Leu Leu 
65                  70                  75                  80  


Thr Met Gly Val Asp Ile Asp Met Ala Arg Lys Arg Gln Pro Gly Val 
                85                  90                  95      


Phe His Arg Met Ile Thr Asn Glu Gln Asp Leu Lys Met Phe Leu Leu 
            100                 105                 110         


Ser Lys Gly Ala Ser Lys Glu Val Ile Ala Ser Ile Ile Ser Arg Tyr 
        115                 120                 125             


Pro Arg Ala Ile Thr Arg Thr Pro Glu Asn Leu Ser Lys Arg Trp Asp 
    130                 135                 140                 


Leu Trp Arg Lys Ile Val Thr Ser Asp Leu Glu Ile Val Asn Ile Leu 
145                 150                 155                 160 


Glu Arg Ser Pro Glu Ser Phe Phe Arg Ser Asn Asn Asn Leu Asn Leu 
                165                 170                 175     


Glu Asn Asn Ile Lys Phe Leu Tyr Ser Val Gly Leu Thr Arg Lys Cys 
            180                 185                 190         


Leu Cys Arg Leu Leu Thr Asn Ala Pro Arg Thr Phe Ser Asn Ser Leu 
        195                 200                 205             


Asp Leu Asn Lys Gln Met Val Glu Phe Leu Gln Ala Ala Gly Leu Ser 
    210                 215                 220                 


Leu Gly His Asn Asp Pro Ala Asp Phe Val Arg Lys Ile Ile Phe Lys 
225                 230                 235                 240 


Asn Pro Phe Ile Leu Ile Gln Ser Thr Lys Arg Val Lys Ala Asn Ile 
                245                 250                 255     


Glu Phe Leu Arg Ser Thr Phe Asn Leu Asn Ser Glu Glu Leu Leu Val 
            260                 265                 270         


Leu Ile Cys Gly Pro Gly Ala Glu Ile Leu Asp Leu Ser Asn Asp Tyr 
        275                 280                 285             


Ala Arg Arg Ser Tyr Ala Asn Ile Lys Glu Lys Leu Phe Ser Leu Gly 
    290                 295                 300                 


Cys Thr Glu Glu Glu Val Gln Lys Phe Val Leu Ser Tyr Pro Asp Val 
305                 310                 315                 320 


Ile Phe Leu Ala Glu Lys Lys Phe Asn Asp Lys Ile Asp Cys Leu Met 
                325                 330                 335     


Glu Glu Asn Ile Ser Ile Ser Gln Ile Ile Glu Asn Pro Arg Val Leu 
            340                 345                 350         


Asp Ser Ser Ile Ser Thr Leu Lys Ser Arg Ile Lys Glu Leu Val Asn 
        355                 360                 365             


Ala Gly Cys Asn Leu Ser Thr Leu Asn Ile Thr Leu Leu Ser Trp Ser 
    370                 375                 380                 


Lys Lys Arg Tyr Glu Ala Lys Leu Lys Lys Leu Ser Arg Phe Ala 
385                 390                 395                 


<210>  2049
<211>  2175
<212>  DNA
<213>  Homosapiens

<400>  2049
atatacttgc gcgccgacgc cgccgctcgc ttgtgaaact ggaaggctgc catggctagc     60

ccagccgcct cctcggtgcg accaccgagg cccaagaaag agccgcagac gctcgtcatc    120

cccaagaatg cggcggagga gcagaagctc aagctggagc ggctcatgaa gaacccggac    180

aaagcagttc caattccaga gaaaatgagt gaatgggcac ctcgacctcc cccagaattt    240

gtccgagatg tcatgggttc aagtgctggg gccggcagtg gagagttcca cgtgtacaga    300

catctgcgcc ggagagaata tcagcgacag gactacatgg atgccatggc tgagaagcaa    360

aaattggatg cagagtttca gaaaagactg gaaaagaata aaattgctgc agaggagcag    420

accgcaaagc gccggaagaa gcgccagaag ttaaaagaga agaaattact ggcaaagaag    480

atgaaacttg aacagaagaa acaagaagga cccggtcagc ccaaggagca ggggtccagc    540

agctctgcgg aggcatctgg aacagaggag gaggaggaag tgcccagttt caccatgggg    600

cgatgacaat gtttgccaca gcctctgcct ggaacctggc tcgtgctgtg accagaaggg    660

aaaggcggct gtttggctct ttctcccccg caaggacccg ctgacccgct ggatggagag    720

caaaggagac ccctcccgag ccgctcacag tcctgtattt ggcaggtttg ggagcctgag    780

gggccatctc cctgacactc agaggcactg ccttgcagac accatccgtg ctcctggtaa    840

agggggacag agagcctcac cttgccacat atttgaacag tgatgagttt ggggctggtt    900

tctgggaagg gaacgtttat ttagtaaaga gcagaacacc cttgcgtttt gttgggacat    960

gtggaccgtg agtcgcaaac actctggaga aggctgagat gccaccattc ccacggggac   1020

tgaagacaca ttacgtggac ctggtcccag gctcagtgag gagatggcct cagctgtggg   1080

gctggtccat gttgcccact cactccagtg ggaagtgggg accacgccat agagggtctg   1140

ctcccactgc agctcccggt gctctcgtgt tctgggaagg cctgggtgtg tgcacaagga   1200

ggcccgggcc agggacttca ccaggggctg ggtcacaagg gcacagggtg tgtggaaagc   1260

gctgtggggg aagagccggt caccggagag tgagcaggcg gagactccaa gctgggctga   1320

gccagagcag aaggcgaggg attcccagcc ggacgggggt tctctcacca acagctgtga   1380

tttcatcccg aagtggaagg gggtctaaac agaacaggct gagagaggcg ggactgggtc   1440

aagtgggtgg agctcctcct tgcatgactg caactgtcgg ggctttccgc cggctcacag   1500

cagttggggc cagcggggag aagagaggcg gaactgctgt gtcctcacgt ggcgcagcct   1560

caaactggca tccaggcact gggcccgtgc agagaaggca cctgcagaga gcagggcagc   1620

ccggcgcagg ggcatgcgcc tagaatccca gctactcgga aggccaaggc aggaggaccg   1680

cttgagtcca gggattcaag gccaacctgg gcaatagagc gagaccctgt ctcttaaaaa   1740

acgatgatga tgaacacaga ggacggggca ctgtgctggg agccaggggg cctgggagga   1800

gccgagacca gccttttacc tcggggtttt gaggccaaca gggacgacag agacagtttc   1860

tagttagagc cttggctcca tttttggatg atttagcccc gagttcctga gtctatttta   1920

tgccccttac gtactttgat agaactaagg aaatagtggt tttgagtgaa gggaaaggaa   1980

acccagaaac attttacgtt gcttttactt ctgtagtgta gattgccccg gcccctctct   2040

gagccctgta gcatctgtga tagcttctgt cccttcatcg gttcatgtca cagggatttt   2100

ctttcccagg aagcggacac ggagagtcag ccctaataaa tgagcacatg ccctggctgt   2160

acattttgaa acctg                                                    2175


<210>  2050
<211>  184
<212>  PRT
<213>  Homosapiens

<400>  2050

Met Ala Ser Pro Ala Ala Ser Ser Val Arg Pro Pro Arg Pro Lys Lys 
1               5                   10                  15      


Glu Pro Gln Thr Leu Val Ile Pro Lys Asn Ala Ala Glu Glu Gln Lys 
            20                  25                  30          


Leu Lys Leu Glu Arg Leu Met Lys Asn Pro Asp Lys Ala Val Pro Ile 
        35                  40                  45              


Pro Glu Lys Met Ser Glu Trp Ala Pro Arg Pro Pro Pro Glu Phe Val 
    50                  55                  60                  


Arg Asp Val Met Gly Ser Ser Ala Gly Ala Gly Ser Gly Glu Phe His 
65                  70                  75                  80  


Val Tyr Arg His Leu Arg Arg Arg Glu Tyr Gln Arg Gln Asp Tyr Met 
                85                  90                  95      


Asp Ala Met Ala Glu Lys Gln Lys Leu Asp Ala Glu Phe Gln Lys Arg 
            100                 105                 110         


Leu Glu Lys Asn Lys Ile Ala Ala Glu Glu Gln Thr Ala Lys Arg Arg 
        115                 120                 125             


Lys Lys Arg Gln Lys Leu Lys Glu Lys Lys Leu Leu Ala Lys Lys Met 
    130                 135                 140                 


Lys Leu Glu Gln Lys Lys Gln Glu Gly Pro Gly Gln Pro Lys Glu Gln 
145                 150                 155                 160 


Gly Ser Ser Ser Ser Ala Glu Ala Ser Gly Thr Glu Glu Glu Glu Glu 
                165                 170                 175     


Val Pro Ser Phe Thr Met Gly Arg 
            180                 


<210>  2051
<211>  2527
<212>  DNA
<213>  Homosapiens

<400>  2051
gcgccccggc cgggccactg ggccacaggc cacgcggcca cgcagtccga gcgggagccg     60

agccgggcgg ggcgagggca gctccgcctg gctcccacca tgagtgctga gcttaacgtg    120

cctatcgacc cctctgctcc tgcctgccct gagcccggcc ataagggcat ggattaccgg    180

gactgggtcc gccgcagcta cctggaactg gtcacctcta accaccactc ggtacaggcc    240

ctgtcgtggc ggaagctcta cctgagcagg gccaagctga aggcctccag caggacctcc    300

gccctcctct ccggctttgc catggtggcc atggtggagg tgcagctgga gacgcagtac    360

cagtacccgc ggccgctgct gattgccttc agcgcctgca ccacggtgct ggtggccgtg    420

cacctgttcg ccctcctcat cagcacctgc atcctgccca atgtggaggc cgtgagcaac    480

atccacaacc tgaactccat cagcgagtcc ccgcatgagc gcatgcaccc ctacatcgag    540

ctggcctggg gcttctccac cgtgcttggc atcctactct tcctggccga ggtggtgctg    600

ctctgctgga tcaagttcct ccccgtggat gcccggcgcc agcctggccc cccacctggc    660

cctgggagtc acacgggctg gcaggccgcc ctggtgtcca ccatcatcat ggtgcccgtg    720

ggcctcatct tcgtggtctt caccatccac ttctaccgct ccctggtgcg ccacaaaacg    780

gagcgccaca accgcgagat cgaggagctc cacaagctca aggtccagct ggacgggcat    840

gagcgcagcc tgcaggtctt gtgaggggcc gagggccggg gctgggagcg gccctgtgcc    900

cgggagtccg cagaggcggg gatttgtcag atgcagacat tttgcaaggc tgccgggtag    960

ttcaagacca aagttttcct cttgtcttaa taccataagg actggatgac ttctcctgag   1020

atagaaccgt ttggttcaat gagggactgt gttgctaaga gcgttggggg caaagccagg   1080

ctggttcctt ggcctcgggg tttcctgggt cggggacacg gtgaagaggc tccagcggga   1140

cctgcccatc agtcctgggc caggaggggc tccaagcagc acccagcggt ccgggggagt   1200

ctcagacccg gcatgcgtgg ctggcagacc tgggagagcc agggcagggt tttgcgttca   1260

gagaaggatt gccccagaga cccgtggtgg acttcatggg tgctgagtgg cccgtgtgac   1320

agtgatgaca cgaaggcttc ggcgtttgag tgggtgcagg tgcacgccag ggcttggtgc   1380

ttccctgcct ggccctggag ggagctgggt ggcctggctt caggggaaga caggagccag   1440

gactcacgtc agcccagcag gtgtgggggg tgctgcagcc ctcggcagtg gggtcaggcc   1500

ctgggggatg tttccaatgg tgggcagcct ggccaggccg gagaagacat gttcacgggc   1560

atctatcaga tgcccccttg aggaggctga gttatttgag ggctgctgca aagtacgcta   1620

ggctcaaatt ctcttttccc agccagagcc ctggccacac ggactcagag gggccaccgg   1680

ggtggggaaa ggacccctcc ccgacccccg cagccactgg cctccagctc tcggccacag   1740

aatggcctct aaggctgact cagccgctcc cttgggctgt ggcagcagga ggcgggggct   1800

ctggctcagg ccccggagcc tgtgcagctt gcccatggcc ctaggcagcg aggggacagc   1860

ctgggggact tcctgcctag gcaaggtcat tggccgggcc tggcctgtgg atagtggggc   1920

caggggccgg cccaggccaa atgagtgccc tccttgttat gacaccaagt gactacaagg   1980

gaggcaagac ccctccaggc ctcccagccg acactgggtc ccaccacaca cagtgactgt   2040

gccgtgcagt gcaggttctg gccttttcct tgaaggcatc tggtaaaccc gaagccacgc   2100

tctcgggccg cacatgcacg ccgcagcacc agctgccctg agctgcttgt acaaccaaac   2160

acctttcccc tcttctccag ctgtaacctg gagagtcagc catgccttgt cttttgttct   2220

catgaatagt cactggggcc gggcgcagtg actcacgcct gtaatcccag cactttggga   2280

ggcctaggtg ggcggatcac ttgaggtcag gagttcgaga ccagcctggc caacatggtg   2340

aaaccctgtc tctactaaaa aaatacagaa aattagctgg gcgtggtggc gggcgcctgt   2400

agccccagct acttgggagg ctgaggcggg agaatggcaa tggcgtgaac ccgggaggca   2460

gagcttgcag tgagctgaga tggcgccact gcactccagc ctgggcgaca gagccagact   2520

caatctc                                                             2527


<210>  2052
<211>  254
<212>  PRT
<213>  Homosapiens

<400>  2052

Met Ser Ala Glu Leu Asn Val Pro Ile Asp Pro Ser Ala Pro Ala Cys 
1               5                   10                  15      


Pro Glu Pro Gly His Lys Gly Met Asp Tyr Arg Asp Trp Val Arg Arg 
            20                  25                  30          


Ser Tyr Leu Glu Leu Val Thr Ser Asn His His Ser Val Gln Ala Leu 
        35                  40                  45              


Ser Trp Arg Lys Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser 
    50                  55                  60                  


Arg Thr Ser Ala Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu 
65                  70                  75                  80  


Val Gln Leu Glu Thr Gln Tyr Gln Tyr Pro Arg Pro Leu Leu Ile Ala 
                85                  90                  95      


Phe Ser Ala Cys Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu 
            100                 105                 110         


Leu Ile Ser Thr Cys Ile Leu Pro Asn Val Glu Ala Val Ser Asn Ile 
        115                 120                 125             


His Asn Leu Asn Ser Ile Ser Glu Ser Pro His Glu Arg Met His Pro 
    130                 135                 140                 


Tyr Ile Glu Leu Ala Trp Gly Phe Ser Thr Val Leu Gly Ile Leu Leu 
145                 150                 155                 160 


Phe Leu Ala Glu Val Val Leu Leu Cys Trp Ile Lys Phe Leu Pro Val 
                165                 170                 175     


Asp Ala Arg Arg Gln Pro Gly Pro Pro Pro Gly Pro Gly Ser His Thr 
            180                 185                 190         


Gly Trp Gln Ala Ala Leu Val Ser Thr Ile Ile Met Val Pro Val Gly 
        195                 200                 205             


Leu Ile Phe Val Val Phe Thr Ile His Phe Tyr Arg Ser Leu Val Arg 
    210                 215                 220                 


His Lys Thr Glu Arg His Asn Arg Glu Ile Glu Glu Leu His Lys Leu 
225                 230                 235                 240 


Lys Val Gln Leu Asp Gly His Glu Arg Ser Leu Gln Val Leu 
                245                 250                 


<210>  2053
<211>  2081
<212>  DNA
<213>  Homosapiens

<400>  2053
gcgcgatggc ggcggctgcc gccgagaccc ccgaagtcct tcgggaatgc ggttgcaagg     60

gcatccggac ctgtctgatc tgcgagcggc agcgcggcag tgacccgccc tgggagctgc    120

ccccagcgaa aacataccgt ttcatttact gctccgacac cggctgggcc gtgggcacag    180

aggagtctga ctttgagggc tgggccttcc ccttcccagg agtgatgctg atcgaggact    240

ttgtgacccg ggaggaagaa gccgagttgg tgcggctcat ggaccgtgac ccctggaagc    300

tctcccagtc tggacggagg aagcaggact atggccccaa agtcaacttt cggaaacaga    360

agctaaagac cgagggcttc tgcggcctcc ccagcttcag ccgggaggtg gtgcggagga    420

tgggcctcta cccggggctg gagggcttcc ggcccgtcga gcagtgcaac ctggactact    480

gccccgagcg gggctctgcc attgaccccc acctggacga cgcctggctg tggggggagc    540

ggctggtcag cctcaacctc ctgtccccca ccgtgctgtc catgtgtcgg gaggcgcccg    600

ggagcctgct cctctgctcg gccccgtcgg ctgccccgga ggccttggtg gacagcgtga    660

tagcacccag ccggtcggtg ctatgccagg aggtggaggt ggccatcccc ttacccgccc    720

gctccctgct ggtcctcacc ggggcggcac ggcaccagtg gaagcatgcc atccaccgca    780

gacacatcga ggcccgccgc gtctgcgtca ctttccggga gctgtcggct gagtttggcc    840

ctggagggag gcagcaagag ctgggccagg aactgctgcg gatcgccctc tccttccagg    900

gaagacccgt gtgaaccgcc tccttggctc cagacttgac tgatcccggg attgaaatga    960

ggagcacaga acagggcctc ctgcaactca cggggtttca agagaagatg gctgacccct   1020

gatgctgtga gcagtgtgag ccctgcccag gagcaggttt tgatgggaac gtacctccag   1080

gcagccccct tccacctgga ccgtggccac acttttttgg ttatttagtt tgtcacagtc   1140

ttggggacat gggatcattt gagcttaaaa aatactgggg gccgggcaca gtggctcaca   1200

cctgtaatcc taacactttg ggaggctgag gtgggcggat cacttgatgc caggagttcg   1260

agaccagcct ggccaacacg gtgaaaaccc gtctctacaa aaactacaaa aattagccgg   1320

gtgtggtgac tcacagccgt aatcccagct actcgggagg ctaaggtggg agaattgctt   1380

gaacctggga ggcggaggtt gcagtgagcc aagatcacgc cactgcactc cagcctcggt   1440

gacagagcaa gactgttttg aaaaaaaaaa aaaatgggaa cattttaaat gattttcacc   1500

tttattatgc atctattttc atggggtttc ccgatatctc actgtccagt cccttcattt   1560

ggggaatgtg ttggattagg gaacagggtt gaagatttga agtttagact aaagagctgg   1620

gaacagcttc agagtcaggc tcagcctgac tcatgcttga cacccccacg cccagggagg   1680

gttgggggat gtgaggaggg cagggaaatc tgagagcctc cttccagccc cataacgctg   1740

ttaacaagta ggaaaaatta aagctcccgg ccaggcgcgg tgactcacac ctgtaatccg   1800

agtactttgc ggggctcagg tgggaggatt gcttgaggcc agcctgggca acatagtgag   1860

acccccatct ctacaaaaaa tacaaacatt agctgggcgt ctgggcatgg tggcacacac   1920

ctgtagtccc agctactcga aaggctgagg cgggaggatg gctttaccac catgtcaagg   1980

ctgcagtgag ctcatgatca taccactgca cttaacttgg caacagagca agaccctgtc   2040

cctaaaataa ataaaaggaa aacaaaaaaa aaaaaaaaaa a                       2081


<210>  2054
<211>  302
<212>  PRT
<213>  Homosapiens

<400>  2054

Met Ala Ala Ala Ala Ala Glu Thr Pro Glu Val Leu Arg Glu Cys Gly 
1               5                   10                  15      


Cys Lys Gly Ile Arg Thr Cys Leu Ile Cys Glu Arg Gln Arg Gly Ser 
            20                  25                  30          


Asp Pro Pro Trp Glu Leu Pro Pro Ala Lys Thr Tyr Arg Phe Ile Tyr 
        35                  40                  45              


Cys Ser Asp Thr Gly Trp Ala Val Gly Thr Glu Glu Ser Asp Phe Glu 
    50                  55                  60                  


Gly Trp Ala Phe Pro Phe Pro Gly Val Met Leu Ile Glu Asp Phe Val 
65                  70                  75                  80  


Thr Arg Glu Glu Glu Ala Glu Leu Val Arg Leu Met Asp Arg Asp Pro 
                85                  90                  95      


Trp Lys Leu Ser Gln Ser Gly Arg Arg Lys Gln Asp Tyr Gly Pro Lys 
            100                 105                 110         


Val Asn Phe Arg Lys Gln Lys Leu Lys Thr Glu Gly Phe Cys Gly Leu 
        115                 120                 125             


Pro Ser Phe Ser Arg Glu Val Val Arg Arg Met Gly Leu Tyr Pro Gly 
    130                 135                 140                 


Leu Glu Gly Phe Arg Pro Val Glu Gln Cys Asn Leu Asp Tyr Cys Pro 
145                 150                 155                 160 


Glu Arg Gly Ser Ala Ile Asp Pro His Leu Asp Asp Ala Trp Leu Trp 
                165                 170                 175     


Gly Glu Arg Leu Val Ser Leu Asn Leu Leu Ser Pro Thr Val Leu Ser 
            180                 185                 190         


Met Cys Arg Glu Ala Pro Gly Ser Leu Leu Leu Cys Ser Ala Pro Ser 
        195                 200                 205             


Ala Ala Pro Glu Ala Leu Val Asp Ser Val Ile Ala Pro Ser Arg Ser 
    210                 215                 220                 


Val Leu Cys Gln Glu Val Glu Val Ala Ile Pro Leu Pro Ala Arg Ser 
225                 230                 235                 240 


Leu Leu Val Leu Thr Gly Ala Ala Arg His Gln Trp Lys His Ala Ile 
                245                 250                 255     


His Arg Arg His Ile Glu Ala Arg Arg Val Cys Val Thr Phe Arg Glu 
            260                 265                 270         


Leu Ser Ala Glu Phe Gly Pro Gly Gly Arg Gln Gln Glu Leu Gly Gln 
        275                 280                 285             


Glu Leu Leu Arg Ile Ala Leu Ser Phe Gln Gly Arg Pro Val 
    290                 295                 300         


<210>  2055
<211>  2220
<212>  DNA
<213>  Homosapiens

<400>  2055
gttaacgccc acgggctcgc gcggcgccgc ctcctgggct cagttaccgc ggacgccagt     60

gccgggctcc aggagacgca gggcgacgcc acacgccggg gtggccgact gggtcagcgc    120

gggctgcgcc tcctcgccat gggccccctc tcggcgcggc tgctaatgca gcgcgggcgc    180

cccaagagcg accggctggg gaagatccgg agtctggacc tgtcaggatt ggagctgctt    240

tccgagcacc tggaccccaa actcctgtgc cgcctgacgc agctgcagga gcttgacctg    300

tctaacaacc acctggagac gctgccggac aacctgggcc tgtcccacct gcgtgtcctc    360

cgctgcgcca acaaccagct gggggatgtt actgccttgt gccagttccc caagctcgag    420

gaactcagcc tggagggcaa ccccttcctg acggtcaatg acaacctgaa agtctccttt    480

ctcctgccca cgctccgtaa ggtcaatggc aaggatgcgt cctcaactta ctctcaggtg    540

gagaacctga atcgggagct gaccagcagg gtcacagctc actgggagaa gttcatggcc    600

acactgggtc ctgaagagga ggctgagaag gcccaggcgg actttgtgaa gtcggctgtc    660

agggatgtcc gctacgggcc cgagtccctc agcgagttca cccagtggcg ggtgcggatg    720

atctctgagg agctggtggc cgccagtagg acccaggtgc aaaaggctaa cagcccagag    780

aagcccccag aagctggagc tgcccacaag cccagggcca gactggcggc cttgaaacgg    840

ccagacgacg tcccactcag cctctctccc agcaagcggg cgtgtgcctc cccgtcggcc    900

caggtggagg gcagccctgt ggcaggctcc gatggcagcc agcctgctgt gaagctggag    960

cccctgcact tcctgcagtg ccacagcaag aacaacagcc cccaggacct cgagacccag   1020

ctgtgggcct gtgccttcga gccggcctgg gaggaggggg ccacatccca gaccgtggcc   1080

acgtgcggcg gggaggctgt gtgcgtaatt gattgccaga cgggcatcgt gctccacaag   1140

tacaaggcac ccggcgagga gttcttttct gtggcctgga ccgctctgat ggtggtcaca   1200

caggctggcc acaagaagcg ctggagtgtg ctggcggctg caggcctacg gggcctggtc   1260

cggctgctgc acgtgcgtgc cggcttctgc tgcggggtca tccgagccca caagaaggcc   1320

atcgccaccc tgtgcttcag ccccgcccac gagacccatc tcttcacggc ctcctatgac   1380

aagcggatca tcctctggga catcggggtg cccaaccagg actacgaatt ccaggccagc   1440

cagctgctca cactggacac cacctctatc cccctgcgcc tctgccctgt cgcctcctgc   1500

ccggacgccc gcctgctggc cggctgcgag ggcggctgct gctgctggga cgtgcggctg   1560

gaccagcccc aaaagaggag ggtgtgtgaa gtggaattcg tcttctctga gggctccgag   1620

gcatctggac ggagagtgga tgggctggca tttgtgaatg aggacatcgt ggcctccaag   1680

gggagcggcc tgggcaccat ctgcctgtgg agctggaggc agacgtgggg gggccggggc   1740

agccagtcca cggtggcagt ggtggtcctg gcgcggctgc aatggtcgtc caccgagttg   1800

gcctacttct cgctcagcgc ctgccctgat aaggggattg tgctctgtgg ggatgaggag   1860

ggcaacgtgt ggctctacga cgtcagcaac atcctgaagc agccacccct gctgccggca   1920

gccctgcagg cccccacaca gatcctgaag tggccccagc cctgggccct tggccaggtg   1980

gtgaccaaga ccatggtgaa cacagtggtg gccaatgcct ccttcaccta cctcaccgcc   2040

ctgacggact ccaacatcgt agccatctgg gggaggatgt agcctcacac catcgcaaag   2100

gaccagggac acagctaact aacttattca gctttgggcc gatgggggtg ggggggggtc   2160

tttcagtgaa tatttttatt aaactctact gtggacaaaa aaaaaaaaaa aaaaaaaaaa   2220


<210>  2056
<211>  647
<212>  PRT
<213>  Homosapiens

<400>  2056

Met Gly Pro Leu Ser Ala Arg Leu Leu Met Gln Arg Gly Arg Pro Lys 
1               5                   10                  15      


Ser Asp Arg Leu Gly Lys Ile Arg Ser Leu Asp Leu Ser Gly Leu Glu 
            20                  25                  30          


Leu Leu Ser Glu His Leu Asp Pro Lys Leu Leu Cys Arg Leu Thr Gln 
        35                  40                  45              


Leu Gln Glu Leu Asp Leu Ser Asn Asn His Leu Glu Thr Leu Pro Asp 
    50                  55                  60                  


Asn Leu Gly Leu Ser His Leu Arg Val Leu Arg Cys Ala Asn Asn Gln 
65                  70                  75                  80  


Leu Gly Asp Val Thr Ala Leu Cys Gln Phe Pro Lys Leu Glu Glu Leu 
                85                  90                  95      


Ser Leu Glu Gly Asn Pro Phe Leu Thr Val Asn Asp Asn Leu Lys Val 
            100                 105                 110         


Ser Phe Leu Leu Pro Thr Leu Arg Lys Val Asn Gly Lys Asp Ala Ser 
        115                 120                 125             


Ser Thr Tyr Ser Gln Val Glu Asn Leu Asn Arg Glu Leu Thr Ser Arg 
    130                 135                 140                 


Val Thr Ala His Trp Glu Lys Phe Met Ala Thr Leu Gly Pro Glu Glu 
145                 150                 155                 160 


Glu Ala Glu Lys Ala Gln Ala Asp Phe Val Lys Ser Ala Val Arg Asp 
                165                 170                 175     


Val Arg Tyr Gly Pro Glu Ser Leu Ser Glu Phe Thr Gln Trp Arg Val 
            180                 185                 190         


Arg Met Ile Ser Glu Glu Leu Val Ala Ala Ser Arg Thr Gln Val Gln 
        195                 200                 205             


Lys Ala Asn Ser Pro Glu Lys Pro Pro Glu Ala Gly Ala Ala His Lys 
    210                 215                 220                 


Pro Arg Ala Arg Leu Ala Ala Leu Lys Arg Pro Asp Asp Val Pro Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Ser Lys Arg Ala Cys Ala Ser Pro Ser Ala Gln Val 
                245                 250                 255     


Glu Gly Ser Pro Val Ala Gly Ser Asp Gly Ser Gln Pro Ala Val Lys 
            260                 265                 270         


Leu Glu Pro Leu His Phe Leu Gln Cys His Ser Lys Asn Asn Ser Pro 
        275                 280                 285             


Gln Asp Leu Glu Thr Gln Leu Trp Ala Cys Ala Phe Glu Pro Ala Trp 
    290                 295                 300                 


Glu Glu Gly Ala Thr Ser Gln Thr Val Ala Thr Cys Gly Gly Glu Ala 
305                 310                 315                 320 


Val Cys Val Ile Asp Cys Gln Thr Gly Ile Val Leu His Lys Tyr Lys 
                325                 330                 335     


Ala Pro Gly Glu Glu Phe Phe Ser Val Ala Trp Thr Ala Leu Met Val 
            340                 345                 350         


Val Thr Gln Ala Gly His Lys Lys Arg Trp Ser Val Leu Ala Ala Ala 
        355                 360                 365             


Gly Leu Arg Gly Leu Val Arg Leu Leu His Val Arg Ala Gly Phe Cys 
    370                 375                 380                 


Cys Gly Val Ile Arg Ala His Lys Lys Ala Ile Ala Thr Leu Cys Phe 
385                 390                 395                 400 


Ser Pro Ala His Glu Thr His Leu Phe Thr Ala Ser Tyr Asp Lys Arg 
                405                 410                 415     


Ile Ile Leu Trp Asp Ile Gly Val Pro Asn Gln Asp Tyr Glu Phe Gln 
            420                 425                 430         


Ala Ser Gln Leu Leu Thr Leu Asp Thr Thr Ser Ile Pro Leu Arg Leu 
        435                 440                 445             


Cys Pro Val Ala Ser Cys Pro Asp Ala Arg Leu Leu Ala Gly Cys Glu 
    450                 455                 460                 


Gly Gly Cys Cys Cys Trp Asp Val Arg Leu Asp Gln Pro Gln Lys Arg 
465                 470                 475                 480 


Arg Val Cys Glu Val Glu Phe Val Phe Ser Glu Gly Ser Glu Ala Ser 
                485                 490                 495     


Gly Arg Arg Val Asp Gly Leu Ala Phe Val Asn Glu Asp Ile Val Ala 
            500                 505                 510         


Ser Lys Gly Ser Gly Leu Gly Thr Ile Cys Leu Trp Ser Trp Arg Gln 
        515                 520                 525             


Thr Trp Gly Gly Arg Gly Ser Gln Ser Thr Val Ala Val Val Val Leu 
    530                 535                 540                 


Ala Arg Leu Gln Trp Ser Ser Thr Glu Leu Ala Tyr Phe Ser Leu Ser 
545                 550                 555                 560 


Ala Cys Pro Asp Lys Gly Ile Val Leu Cys Gly Asp Glu Glu Gly Asn 
                565                 570                 575     


Val Trp Leu Tyr Asp Val Ser Asn Ile Leu Lys Gln Pro Pro Leu Leu 
            580                 585                 590         


Pro Ala Ala Leu Gln Ala Pro Thr Gln Ile Leu Lys Trp Pro Gln Pro 
        595                 600                 605             


Trp Ala Leu Gly Gln Val Val Thr Lys Thr Met Val Asn Thr Val Val 
    610                 615                 620                 


Ala Asn Ala Ser Phe Thr Tyr Leu Thr Ala Leu Thr Asp Ser Asn Ile 
625                 630                 635                 640 


Val Ala Ile Trp Gly Arg Met 
                645         


<210>  2057
<211>  991
<212>  DNA
<213>  Homosapiens

<400>  2057
aagaggcctc ttattagggc tctggtggcg gcggcggcgg acccttgggg tctggacgca     60

acggcggcgg gagcatgaac gcccctccag ccttcgagtc gttcttgctc ttcgagggcg    120

agaagaagat caccattaac aaggacacca aggtacccaa tgcctgttta ttcaccatca    180

acaaagaaga ccacacactg ggaaacatca ttaaatcaca actcctaaaa gacccgcaag    240

tgctatttgc tggctacaaa gtcccccacc ccttggagca caagatcatc atccgagtgc    300

agaccacgcc ggactacagc ccccaggaag cctttaccaa cgccatcacc gacctcatca    360

gtgagctgtc cctgctggag gagcgctttc gggtggccat aaaagacaag caggaaggaa    420

ttgagtaggg gccagagggg gctctgctcg gcctgtgagc cccgttccta cctgtgcctg    480

accctccgct ccaggtacca caccgaggag agcggccggt cccagccatg gcccgccttg    540

tggccacccc tcaccctgac accgacgtgt cctgtacata gattaggttt tatattccta    600

ataaagtata gcgggagaga cctggatgtg gacttgagca gcggtgactt cgcaagcaaa    660

tggattgtca ggcttgatgc aggcagatga cctgtttcag gggcgtccgg ctggcaggga    720

tgaattcatt ctggaccaaa gatccggggt ccaggggctg ctgcgggggc tgtgctgagc    780

cggagagaag tgtgcaaacc catgagctcc caagagtctc tgctctagaa gcctcaactc    840

ctgggcctgc ctgtcagtca aagcaggaac acttcttcct gcataactcg aaacaccttt    900

ccacaggctt cttgtccaca gtagagttta ataaaaatat tcactgaaag accccccccc    960

acccccatcg gcccaaaaaa aaaaaaaaaa a                                   991


<210>  2058
<211>  117
<212>  PRT
<213>  Homosapiens

<400>  2058

Met Asn Ala Pro Pro Ala Phe Glu Ser Phe Leu Leu Phe Glu Gly Glu 
1               5                   10                  15      


Lys Lys Ile Thr Ile Asn Lys Asp Thr Lys Val Pro Asn Ala Cys Leu 
            20                  25                  30          


Phe Thr Ile Asn Lys Glu Asp His Thr Leu Gly Asn Ile Ile Lys Ser 
        35                  40                  45              


Gln Leu Leu Lys Asp Pro Gln Val Leu Phe Ala Gly Tyr Lys Val Pro 
    50                  55                  60                  


His Pro Leu Glu His Lys Ile Ile Ile Arg Val Gln Thr Thr Pro Asp 
65                  70                  75                  80  


Tyr Ser Pro Gln Glu Ala Phe Thr Asn Ala Ile Thr Asp Leu Ile Ser 
                85                  90                  95      


Glu Leu Ser Leu Leu Glu Glu Arg Phe Arg Val Ala Ile Lys Asp Lys 
            100                 105                 110         


Gln Glu Gly Ile Glu 
        115         


<210>  2059
<211>  918
<212>  DNA
<213>  Homosapiens

<400>  2059
ggggggagag gtagagatga gacaagaggt agaggggaga ggtagaggta gccacgagct     60

gataattaca gacaagagat gcggagtatg tgggggctca ttatcctgca tagtctatct    120

ttgtatatct ttgaactttt caagaataaa aaagcttaaa aagtatacat ggcctggtcc    180

taccagagac tcacccaatg ccagcctcca gccagggaga gccaagtttg cattttcaca    240

cgcatctcac actcctctgc actctcaact tggagagctc caaacaggga aaccccaagc    300

cttgctggct tctgccaacc ccctgagcag aagcatgggt ccccctgatc accacctcac    360

caccctcatc ctgatctcac tgtacactcc ctttcctggt ctgctaagta gcgggtgttt    420

tccttgacac taacgctaca gctagaccac ggtgggcttg gcaacaggtg tcttcccaga    480

tgctggcgtt accgctagac caaggagccc tctggtggcc ccgtccgggc ataacagaaa    540

gctcgcactc ttgtcttctg gtcactcctc actgtcccct tcagcctcct atctctgtat    600

ggcctggtgt ttcctaggtt atgattgtag agcgaggatt attataatat tggaataaag    660

aataattact acaaactaat gattaatgat tcatatataa tcatatctaa gatctatatc    720

tagtataact attcttattt tatatatttt attatactgg aacagctcgt gccctcggtc    780

tcttgcctcg gcacctgggt ggcttgctgc ccacatccac caagtgcact ttgggaggct    840

gaggctggag gactgctgga ggccaggagt tcaataccag cctgggcaac atagggagac    900

ccccccccca ccatctcc                                                  918


<210>  2060
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  2060

Met Arg Gln Glu Val Glu Gly Arg Gly Arg Gly Ser His Glu Leu Ile 
1               5                   10                  15      


Ile Thr Asp Lys Arg Cys Gly Val Cys Gly Gly Ser Leu Ser Cys Ile 
            20                  25                  30          


Val Tyr Leu Cys Ile Ser Leu Asn Phe Ser Arg Ile Lys Lys Leu Lys 
        35                  40                  45              


Lys Tyr Thr Trp Pro Gly Pro Thr Arg Asp Ser Pro Asn Ala Ser Leu 
    50                  55                  60                  


Gln Pro Gly Arg Ala Lys Phe Ala Phe Ser His Ala Ser His Thr Pro 
65                  70                  75                  80  


Leu His Ser Gln Leu Gly Glu Leu Gln Thr Gly Lys Pro Gln Ala Leu 
                85                  90                  95      


Leu Ala Ser Ala Asn Pro Leu Ser Arg Ser Met Gly Pro Pro Asp His 
            100                 105                 110         


His Leu Thr Thr Leu Ile Leu Ile Ser Leu Tyr Thr Pro Phe Pro Gly 
        115                 120                 125             


Leu Leu Ser Ser Gly Cys Phe Pro 
    130                 135     


<210>  2061
<211>  1221
<212>  DNA
<213>  Homosapiens

<400>  2061
gggaggatgg agagtggttt ggggttttgg gtcgggctct agtgtgatca actgcagaag     60

cattacaccg tggcctggtt tctttactca gcccctgggt tagatcccag ccccccgcat    120

aggtcctttt gctggaaaag gaagatggag tggtgggacg aatctgagga gtcgttggag    180

gaggagccac ggaaggtgct cgcccctgag cctgaggaga tctgggtggc ggagatgctg    240

tgtggcctca agatgaagct gaagcgacgg cgagtgtcgc tcgtgctccc tgagcaccac    300

gaggccttca acaggctgct tgaggatcct gtcattaaaa gattcttggc ctgggacaaa    360

gatctgaggg tgtcggacaa gtatctcctg gctatggtca tagcgtattt cagccgggcc    420

ggcttcccct cctggcaata ccaacgcatt catttcttcc tggctctcta cctggccaat    480

gacatggagg aggacgacga ggactccaaa caaaacatct tccacttcct gtataggaag    540

aaccgctctc gcataccctt gctccgtaag cgttggttcc agttaggcca ttccatgaac    600

ccgagggcca ggaagaaccg ctctcgcata cccttgctcc gtaagcgtcg gttccagtta    660

taccgttcca cgaacccgag ggccaggaag aaccgctctc gcataccctt gctccgtaag    720

cgtcggttcc agttataccg ttccatgaac tcgagggcca ggaagaaccg ctctcagata    780

gtcctgttcc agaaacgacg gttccacttc ttctgttcca tgagctgcag ggcttgggtt    840

tccccagagg agttggagga gatccaggct tatgacccag agcactgggt gtgggcgcga    900

gatcgcgctc acctttccta gagctccagg gaccggggag gcctgaggtc atcggcctga    960

gagaagaaca ccggacccag gggagatgtg gattttcagc aggaacttta ttccaatgct   1020

aatggcagac accaggcagg aggagaggaa ccatttgtgc agatcatcta gaagaacctg   1080

gaccattctt gatggagctg aatacagtga tcacgttgtc ctcctaggag caggggtggg   1140

gggagggggg tggggtcctt ctaggagtcc ttggagaaaa gtaagaaacc aggagcgttt   1200

ccagttccac cctttcctgg g                                             1221


<210>  2062
<211>  258
<212>  PRT
<213>  Homosapiens

<400>  2062

Met Glu Trp Trp Asp Glu Ser Glu Glu Ser Leu Glu Glu Glu Pro Arg 
1               5                   10                  15      


Lys Val Leu Ala Pro Glu Pro Glu Glu Ile Trp Val Ala Glu Met Leu 
            20                  25                  30          


Cys Gly Leu Lys Met Lys Leu Lys Arg Arg Arg Val Ser Leu Val Leu 
        35                  40                  45              


Pro Glu His His Glu Ala Phe Asn Arg Leu Leu Glu Asp Pro Val Ile 
    50                  55                  60                  


Lys Arg Phe Leu Ala Trp Asp Lys Asp Leu Arg Val Ser Asp Lys Tyr 
65                  70                  75                  80  


Leu Leu Ala Met Val Ile Ala Tyr Phe Ser Arg Ala Gly Phe Pro Ser 
                85                  90                  95      


Trp Gln Tyr Gln Arg Ile His Phe Phe Leu Ala Leu Tyr Leu Ala Asn 
            100                 105                 110         


Asp Met Glu Glu Asp Asp Glu Asp Ser Lys Gln Asn Ile Phe His Phe 
        115                 120                 125             


Leu Tyr Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Arg Trp 
    130                 135                 140                 


Phe Gln Leu Gly His Ser Met Asn Pro Arg Ala Arg Lys Asn Arg Ser 
145                 150                 155                 160 


Arg Ile Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu Tyr Arg Ser Thr 
                165                 170                 175     


Asn Pro Arg Ala Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys 
            180                 185                 190         


Arg Arg Phe Gln Leu Tyr Arg Ser Met Asn Ser Arg Ala Arg Lys Asn 
        195                 200                 205             


Arg Ser Gln Ile Val Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys 
    210                 215                 220                 


Ser Met Ser Cys Arg Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Ile 
225                 230                 235                 240 


Gln Ala Tyr Asp Pro Glu His Trp Val Trp Ala Arg Asp Arg Ala His 
                245                 250                 255     


Leu Ser 
        


<210>  2063
<211>  5579
<212>  DNA
<213>  Homosapiens

<400>  2063
ggaccccggt gtctggcttc ccccgagccg ggaccccgcg atggccaagc gcagctcgct     60

gtacatccgc atcgtggagg ggaagaacct tcccgccaag gacatcactg gcagcagcga    120

cccctactgc atcgtgaagg tggacaatga gcccatcatc aggacagcca cagtgtggaa    180

gaccctgtgc cccttctggg gtgaggagta ccaagtgcac ctgccgccca ccttccacgc    240

tgtggctttc tatgtcatgg atgaggatgc cctcagccgg gacgacgtta tcggaaaggt    300

ctgccttaca agggacacca tagcctctca ccctaagggt ttcagcgggt gggcccacct    360

gacggaggtc gaccccgacg aggaggtgca gggcgagatc cacctgcggc tggaagtgtg    420

gccaggggcc cgggcctgcc ggctacgctg ctctgtgctg gaggccaggg atctggcccc    480

aaaggaccgc aatggcacat ctgacccctt cgtccgagtg cgctacaagg gccggacacg    540

ggagacctcg atcgtgaaga agtcatgcta cccacgctgg aatgagacgt ttgaatttga    600

gctgcaggag ggggccatgg aggcactgtg cgtggaggcc tgggactggg accttgtcag    660

ccgaaacgac ttcctgggca aagtggtgat tgatgtccag agactgcggg tggtgcagca    720

ggaggagggc tggttccggc tgcagcccga ccagtccaag agccggcggc atgacgaggg    780

caacctgggc tccttgcagc tggaggtgcg gctgcgggac gagacggtgc tgccctccag    840

ctactaccag ccactggtgc acctgctgtg ccacgaggtc aagctgggca tgcagggccc    900

agggcagctg atcccactca tcgaggagac aaccagcacc gagtgtcgcc aggacgtggc    960

cacgaacctg ctcaagctct tcctggggca ggggctggcc aaggacttcc tggacctgct   1020

cttccagctg gagctgagtc gcaccagtga gaccaacacc ctgttccgga gcaactctct   1080

ggcctcaaag tccatggagt cttttctgaa ggtggccggg atgcagtacc tgcacggcgt   1140

cctgggcccc atcatcaaca aggtgtttga ggagaagaag tacgtggagc tggaccccag   1200

caaagtggaa gttaaggatg tagggtgctc cgggctgcac cgcccgcaga ccgaggccga   1260

ggtgctggag cagagcgcgc agacgctgcg cgcccacctg ggggccctgc tgagcgcgct   1320

cagccgctcg gttcgcgcgt gccccgccgt ggtgcgcgcc accttccgcc agctcttccg   1380

gcgcgtgcgc gagcgcttcc ccggcgccca gcacgagaat gtaccgttca tcgccgtcac   1440

cagcttcctg tgcctgcgct tcttctctcc cgccatcatg tcgcccaagc tcttccacct   1500

gcgggagcgc cacgcggacg cccgcaccag ccgcaccctg ctcctgttgg ccaaggcagt   1560

ccagaacgtg ggcaacatgg acacgccggc ttccagggcc aaggaggctt ggatggagcc   1620

gctgcagccc accgtgcgcc agggcgtggc gcagctgaag gacttcatca ccaagctcgt   1680

ggacatcgag gagaaggacg agctggacct gcagcggacg ctgagtttgc aggcgccacc   1740

tgtgaaggag gggccactct tcatccacag gaccaagggc aagggccccc tcatgtcctc   1800

ctccttcaag aagctctact tctccctcac taccgaggcc ctcagcttcg cgaagatgcc   1860

cagctccaag aaaagcgccc tcatcaagtt agccaacatc cgggcagcgg aaaaggttga   1920

ggaaaagagc tttggcggct cgcacgtcat gcaggtcatc tacacggacg acgccggcag   1980

gccccagact gcctacctgc agtgcaagtg tgtgaatgag cttaaccagt ggctgtctgc   2040

gctgcggaag gtgagcatca acaacaccgg actgctgggc tcctaccacc ctggcgtctt   2100

ccgtggggac aagtggagct gctgccacca aaaagagaag acaggtcagg gctgcgataa   2160

gacccggtca cgggtgaccc tgcaggagtg gaatgaccct cttgaccatg accttgaggc   2220

ccagctcatc taccggcacc tgctgggcgt ggaggccatg ctgtgggaga ggcaccggga   2280

gctgagcggg ggcacagagg caggcacggt gcccacgagc cctggcaaag tccccgagga   2340

ctcattggcc cggctgctcc gggtgctgca ggacctccgc gaggcccata gctccagccc   2400

ggccggctcc ccaccctcag agcccaactg cctcctggag ctgcagacgt gaggcccgcc   2460

ctacgctccc cttgctgagt cccctgccaa gcgctcggag cccccccagg acactctgca   2520

ccccctcacc ccggtcctcc tcattagggt gcagggccta ggtctcttcc aggtggggga   2580

ggggggagag tcaggaataa ggggatcccc agaagtgcag agctgagcag gcttgggcct   2640

gtcatggctg gccggaagtg tccccagctc cctacagacg ctgtagccat cactgcctct   2700

ccagggaccc tcctctcctg cccaggacag acccagccag aaccactgct aggatgggcc   2760

gcacccaggg gtctggcctc cagggaccta gagaatggga gggagaacgg ggccccagga   2820

gacccggccg ccaccccacc cgctaccctt gggtgccaca gggctgtgct gttgccaaca   2880

gtaaacctgc tcttactgtc caggctctgg ggtcttgtga tgagggtctg gggagaaagt   2940

gggcccgggg ggaccccgga ggctgtcggt ggatgtgccg atgatggggc tgacagtatg   3000

ggctctgggc atccctgttc cccccccttt cttcccccca ctcttctggg gtcgggggtt   3060

cctttccctt cccagttgct gtccctgggt cccctctttc atgtcccaca ggccacagag   3120

cccagtgtgt ccaaccagct gttctctcct caaagcagcc cccaagcaag tcccttctct   3180

agggtgtccc tgaggacagc acagaggcgg gactcagaga ccccattcct cttcacgcag   3240

cccttacccc aagccctcta gctgtgtggc tggcagtgtt ggccacgtag gggctcccat   3300

ccccccacca ttgtgtcaca tgggctgcca ggctcagctc ccagctgcgt ccacagtgac   3360

ctggatcagg gtggggacaa ggactggacc ctccttctcc agaaggcctt cagctcttgc   3420

cttgccatgc agtcacctcc ttccccctct gaccccagat cccaaaggtg caccgttgcc   3480

ccagcccctt tctggcccca tggggtttct ctgatgcctt catcatagag gcccggggct   3540

ggtccgatgg ttggcaaaac ttgactccgg cccagtcccc actcttgggg acttagaacc   3600

cctgctgtcc tgggatctgg cctgcctttc tttggtcagt ccctgtggtc ccccaccagc   3660

tccccctccc atagggctgc ccaccaagcc ctgcccccag cccaagagga gcccccactg   3720

cctgcggggc agtgatgtct ggccaccggc tcacaccaat gacttggtcc tggggtggca   3780

gaagcagcag gtgacaggag cagggcccct gtccctctct tctggccctg tggtacccag   3840

gccacacgtt gtgcccgctc ttggggctga ccggctgtag ggaccaccag ccgctgctac   3900

tgtgggccgc cccggggcag ggtgggcagg gcttttgtgg gttatgagga cacagaagtc   3960

cctgaggccc ccagacctgg ctcagccaac ctccttcctc ccccggttgc cccccactct   4020

aaagcctcct ccctcccagc gtccactggc tccaggctcc tcacaacagc agctcataga   4080

cacggggcgt ctccaggtgg tcccagccct ccagatgttt ctagctctcc aggtgggcgc   4140

tgttttcacg tctgcctgca tccattcatt ccttcattcc tcacctttat cctgttatct   4200

ctattttttt aagctaccag gaaggaaagg gaagaagaga tcacgaaact gggaccccca   4260

gaagggagga gtgggctttg aacttagaca tctacctcag agctcaaata ggttgtttaa   4320

aatcacattc aattttcaga tgaaggggaa ctttatagtt tttttttttt tttttttttt   4380

ttttggggcg gagtctcact gtgttgccca ggctggagtg caaatggctt gatcttggtt   4440

cactgcaacc tctgcctccc aggttcaagc aattctcttg cctcggcctc ccgagtagct   4500

gggactggag gcgtgtgcca ccatgcccag ctaattcttg tatttttagt agagacggag   4560

tttctccatg ttggccagac tggtctcgaa ctcctgacct caggtgatct gaccgccttg   4620

gcctccgaaa gtgctgagat tacagttgcg agccactgtg cgtggccaga actttataat   4680

aagagacttg aagctgggtg tgacggtgca cgcctctggt cccagctgct cgggaggccg   4740

ggacagaagg atcaccttga ggccaggagt ttaaggccag cctgggcaac atagcaaaac   4800

ctagtcccta aaattaaaaa aaaaaaaaaa aaaaaaggaa aataaaggag acttgaaatt   4860

tttgaactaa atagtggtga tggctacaca ttgtgaatgt aattaacacc actgagttaa   4920

acacttaaaa tggttaaaat ggcaaattgt atgttatacc tattttacta caataaaaag   4980

tataaaaaag agaagatatt taggtgactt acagcaacca attgcaacaa aacaaaatgt   5040

taagaaatga tctttttatg aggcaattgg aaatttgaac actgatcaac tataggatga   5100

ttggaattat taatttttaa aggtgtgata agatgctgca cttggctggg cacagtggca   5160

catgcctgta atcccagcta cttggcaggc tgaggtggga gaatcgcttg agctcaggag   5220

ttcgagacca gcctgggcaa cgtggcgaaa tccccgtctt tacaaaaaca aacaaacaaa   5280

caaaaaagat attgcagttg tgttgtaagc gtccttatct ttcagagcta catagtggaa   5340

tgtttatgga atatttagga taaatgatat aggcatttgg gatttgctgc aaaatgaccc   5400

agaggcaggg gtcaggggga gaggtagaga tgagacaaga ggtagagggg agaggtagag   5460

gtagccacga gctgataatt acagacaaga gatgcggagt atgtgggggc tcattatcct   5520

gcatagtcta tctttgtata tctttgaact tttcaagaat aaaaaagctt aaaaagtat    5579


<210>  2064
<211>  803
<212>  PRT
<213>  Homosapiens

<400>  2064

Met Ala Lys Arg Ser Ser Leu Tyr Ile Arg Ile Val Glu Gly Lys Asn 
1               5                   10                  15      


Leu Pro Ala Lys Asp Ile Thr Gly Ser Ser Asp Pro Tyr Cys Ile Val 
            20                  25                  30          


Lys Val Asp Asn Glu Pro Ile Ile Arg Thr Ala Thr Val Trp Lys Thr 
        35                  40                  45              


Leu Cys Pro Phe Trp Gly Glu Glu Tyr Gln Val His Leu Pro Pro Thr 
    50                  55                  60                  


Phe His Ala Val Ala Phe Tyr Val Met Asp Glu Asp Ala Leu Ser Arg 
65                  70                  75                  80  


Asp Asp Val Ile Gly Lys Val Cys Leu Thr Arg Asp Thr Ile Ala Ser 
                85                  90                  95      


His Pro Lys Gly Phe Ser Gly Trp Ala His Leu Thr Glu Val Asp Pro 
            100                 105                 110         


Asp Glu Glu Val Gln Gly Glu Ile His Leu Arg Leu Glu Val Trp Pro 
        115                 120                 125             


Gly Ala Arg Ala Cys Arg Leu Arg Cys Ser Val Leu Glu Ala Arg Asp 
    130                 135                 140                 


Leu Ala Pro Lys Asp Arg Asn Gly Thr Ser Asp Pro Phe Val Arg Val 
145                 150                 155                 160 


Arg Tyr Lys Gly Arg Thr Arg Glu Thr Ser Ile Val Lys Lys Ser Cys 
                165                 170                 175     


Tyr Pro Arg Trp Asn Glu Thr Phe Glu Phe Glu Leu Gln Glu Gly Ala 
            180                 185                 190         


Met Glu Ala Leu Cys Val Glu Ala Trp Asp Trp Asp Leu Val Ser Arg 
        195                 200                 205             


Asn Asp Phe Leu Gly Lys Val Val Ile Asp Val Gln Arg Leu Arg Val 
    210                 215                 220                 


Val Gln Gln Glu Glu Gly Trp Phe Arg Leu Gln Pro Asp Gln Ser Lys 
225                 230                 235                 240 


Ser Arg Arg His Asp Glu Gly Asn Leu Gly Ser Leu Gln Leu Glu Val 
                245                 250                 255     


Arg Leu Arg Asp Glu Thr Val Leu Pro Ser Ser Tyr Tyr Gln Pro Leu 
            260                 265                 270         


Val His Leu Leu Cys His Glu Val Lys Leu Gly Met Gln Gly Pro Gly 
        275                 280                 285             


Gln Leu Ile Pro Leu Ile Glu Glu Thr Thr Ser Thr Glu Cys Arg Gln 
    290                 295                 300                 


Asp Val Ala Thr Asn Leu Leu Lys Leu Phe Leu Gly Gln Gly Leu Ala 
305                 310                 315                 320 


Lys Asp Phe Leu Asp Leu Leu Phe Gln Leu Glu Leu Ser Arg Thr Ser 
                325                 330                 335     


Glu Thr Asn Thr Leu Phe Arg Ser Asn Ser Leu Ala Ser Lys Ser Met 
            340                 345                 350         


Glu Ser Phe Leu Lys Val Ala Gly Met Gln Tyr Leu His Gly Val Leu 
        355                 360                 365             


Gly Pro Ile Ile Asn Lys Val Phe Glu Glu Lys Lys Tyr Val Glu Leu 
    370                 375                 380                 


Asp Pro Ser Lys Val Glu Val Lys Asp Val Gly Cys Ser Gly Leu His 
385                 390                 395                 400 


Arg Pro Gln Thr Glu Ala Glu Val Leu Glu Gln Ser Ala Gln Thr Leu 
                405                 410                 415     


Arg Ala His Leu Gly Ala Leu Leu Ser Ala Leu Ser Arg Ser Val Arg 
            420                 425                 430         


Ala Cys Pro Ala Val Val Arg Ala Thr Phe Arg Gln Leu Phe Arg Arg 
        435                 440                 445             


Val Arg Glu Arg Phe Pro Gly Ala Gln His Glu Asn Val Pro Phe Ile 
    450                 455                 460                 


Ala Val Thr Ser Phe Leu Cys Leu Arg Phe Phe Ser Pro Ala Ile Met 
465                 470                 475                 480 


Ser Pro Lys Leu Phe His Leu Arg Glu Arg His Ala Asp Ala Arg Thr 
                485                 490                 495     


Ser Arg Thr Leu Leu Leu Leu Ala Lys Ala Val Gln Asn Val Gly Asn 
            500                 505                 510         


Met Asp Thr Pro Ala Ser Arg Ala Lys Glu Ala Trp Met Glu Pro Leu 
        515                 520                 525             


Gln Pro Thr Val Arg Gln Gly Val Ala Gln Leu Lys Asp Phe Ile Thr 
    530                 535                 540                 


Lys Leu Val Asp Ile Glu Glu Lys Asp Glu Leu Asp Leu Gln Arg Thr 
545                 550                 555                 560 


Leu Ser Leu Gln Ala Pro Pro Val Lys Glu Gly Pro Leu Phe Ile His 
                565                 570                 575     


Arg Thr Lys Gly Lys Gly Pro Leu Met Ser Ser Ser Phe Lys Lys Leu 
            580                 585                 590         


Tyr Phe Ser Leu Thr Thr Glu Ala Leu Ser Phe Ala Lys Met Pro Ser 
        595                 600                 605             


Ser Lys Lys Ser Ala Leu Ile Lys Leu Ala Asn Ile Arg Ala Ala Glu 
    610                 615                 620                 


Lys Val Glu Glu Lys Ser Phe Gly Gly Ser His Val Met Gln Val Ile 
625                 630                 635                 640 


Tyr Thr Asp Asp Ala Gly Arg Pro Gln Thr Ala Tyr Leu Gln Cys Lys 
                645                 650                 655     


Cys Val Asn Glu Leu Asn Gln Trp Leu Ser Ala Leu Arg Lys Val Ser 
            660                 665                 670         


Ile Asn Asn Thr Gly Leu Leu Gly Ser Tyr His Pro Gly Val Phe Arg 
        675                 680                 685             


Gly Asp Lys Trp Ser Cys Cys His Gln Lys Glu Lys Thr Gly Gln Gly 
    690                 695                 700                 


Cys Asp Lys Thr Arg Ser Arg Val Thr Leu Gln Glu Trp Asn Asp Pro 
705                 710                 715                 720 


Leu Asp His Asp Leu Glu Ala Gln Leu Ile Tyr Arg His Leu Leu Gly 
                725                 730                 735     


Val Glu Ala Met Leu Trp Glu Arg His Arg Glu Leu Ser Gly Gly Thr 
            740                 745                 750         


Glu Ala Gly Thr Val Pro Thr Ser Pro Gly Lys Val Pro Glu Asp Ser 
        755                 760                 765             


Leu Ala Arg Leu Leu Arg Val Leu Gln Asp Leu Arg Glu Ala His Ser 
    770                 775                 780                 


Ser Ser Pro Ala Gly Ser Pro Pro Ser Glu Pro Asn Cys Leu Leu Glu 
785                 790                 795                 800 


Leu Gln Thr 
            


<210>  2065
<211>  1552
<212>  DNA
<213>  Homosapiens

<400>  2065
acggggggcg atgagccgat ccttgggcgg gtttgccccg ccggagtaat ccggaagagg     60

cctcttatta gggctctggt ggcggcggtg gcggacactt ggggtctgga cgcaacggcg    120

gcgggagcat gaacgcccct ccagccttcg agtcgttctt gctcttcgag ggcgagaaga    180

tcaccattaa caaggacacc aaggtaccca aggcctgctt attcaccatc aacaaagaag    240

accacacact gggaaacatc attaaatcac gtgcctgctt ccccttcgcc ttctgccgtg    300

attgtcagtt tcctgaggcc tccccagcca cgcttcctgt acagcctgca gaactctgcc    360

ccagagcaca tcagctatgt gccccagctc tcaaacgaca ccttggcggg gaggctcacc    420

ctgtccacct tcacgctgga gcagcctcta ggccagttca gcagccacaa catctctgac    480

ttggatacca tctggctggt ggtggccctc agcaacgcca cccagagctt cacggcccca    540

cggacaaacc aggacatccc tgctcctgcc aacttctccc agaggggcta ctatctcaca    600

ctgagggcca accgggtgct gtaccagacc agaggccagc tccatgtcct ccgcgtcggc    660

aatgataccc actgccaacc aacaaaaatt ggctgcaacc atcccctacc aggacccggc    720

ccctacaggg tgaagttcct ggtgatgaat gacgaaggac ccgtggctga aaccaagtgg    780

tccagcgaca ctcgcctgca gcaagcccag gcacttcggg ctgtccccgg cccccagagc    840

ccgggcaccg tggtcatcat cgccatcctg tctatcctcc tggccgtcct cctcacggtc    900

ctcctggctg tgctcatata cacctgcttc aacagctgca ggagcacttc cctatcaggc    960

ccagaggagg cagggagtgt gagaagatac accacgcacc tcgcgttcag cactcctgcc   1020

gagggggctt cctgaggggt tccagagggg cccacgtgtc cctccacctc ctccctggcc   1080

caggctgcag agcctgagct gggacacgcc ctgaagcttc tggaccctga gagagattgt   1140

ttcttttctt tactattttt tttttttttt ttgagacgga gtctcactct gtcgccaggc   1200

tggcgcgatc ttggctcact gcaacctctg cctcacgggt tcaagcgatt ttcctgcttc   1260

agcctcctga gtagctggga ctacaggcac acgccaccat gcccagctca tttttgtatt   1320

tttagtagag atggggtttc accatgttgg ccaggatggc ctccatctct tgaccttgtg   1380

atccgcccga ctcggcctcc caaaatgctg ggattacagg cgtgagccat caagtctggc   1440

gagagagatt gtttctagat gagggtgggg gcgggtgtcc ttagcccaaa gcttgtgcca   1500

gtctctatca gaaataaatg cccccaaaac ctcaaaaaaa aaaaaaaaaa aa           1552


<210>  2066
<211>  116
<212>  PRT
<213>  Homosapiens

<400>  2066

Met Asn Ala Pro Pro Ala Phe Glu Ser Phe Leu Leu Phe Glu Gly Glu 
1               5                   10                  15      


Lys Ile Thr Ile Asn Lys Asp Thr Lys Val Pro Lys Ala Cys Leu Phe 
            20                  25                  30          


Thr Ile Asn Lys Glu Asp His Thr Leu Gly Asn Ile Ile Lys Ser Arg 
        35                  40                  45              


Ala Cys Phe Pro Phe Ala Phe Cys Arg Asp Cys Gln Phe Pro Glu Ala 
    50                  55                  60                  


Ser Pro Ala Thr Leu Pro Val Gln Pro Ala Glu Leu Cys Pro Arg Ala 
65                  70                  75                  80  


His Gln Leu Cys Ala Pro Ala Leu Lys Arg His Leu Gly Gly Glu Ala 
                85                  90                  95      


His Pro Val His Leu His Ala Gly Ala Ala Ser Arg Pro Val Gln Gln 
            100                 105                 110         


Pro Gln His Leu 
        115     


<210>  2067
<211>  1727
<212>  DNA
<213>  Homosapiens

<400>  2067
acggggggcg atgagccgat ccttgggcgg gtttgccccg ccggagtaat ccggaagagg     60

cctcttatta gggctctggt ggcggcggtg gcggacactt ggggtctgga cgcaacggcg    120

gcgggagcat gaacgcccct ccagccttcg agtcgttctt gctcttcgag ggcgagaaga    180

tcaccattaa caaggacacc aaggtaccca aggcctgctt attcaccatc aacaaagaag    240

accacacact gggaaacatc attaaatcac aactcctaaa agacccgcaa gtgctatttg    300

ctggctacaa agtcccccac cccttggagc acaagatcat catccgagtg cagaccacgc    360

cggactacag cccccaggaa gcctttacca acgccatcac cgacctcatc agtgagctgt    420

ccctgctgga ggagcgcttc cggacgtgcc tgcttcccct tcgccttctg ccgtgattgt    480

cagtttcctg aggcctcccc agccacgctt cctgtacagc ctgcagaact ctgccccaga    540

gcacatcagc tatgtgcccc agctctcaaa cgacaccttg gcggggaggc tcaccctgtc    600

caccttcacg ctggagcagc ctctaggcca gttcagcagc cacaacatct ctgacttgga    660

taccatctgg ctggtggtgg ccctcagcaa cgccacccag agcttcacgg ccccacggac    720

aaaccaggac atccctgctc ctgccaactt ctcccagagg ggctactatc tcacactgag    780

ggccaaccgg gtgctgtacc agaccagagg ccagctccat gtcctccgcg tcggcaatga    840

tacccactgc caaccaacaa aaattggctg caaccatccc ctaccaggac ccggccccta    900

cagggtgaag ttcctggtga tgaatgacga aggacccgtg gctgaaacca agtggtccag    960

cgacactcgc ctgcagcaag cccaggcact tcgggctgtc cccggccccc agagcccggg   1020

caccgtggtc atcatcgcca tcctgtctat cctcctggcc gtcctcctca cggtcctcct   1080

ggctgtgctc atatacacct gcttcaacag ctgcaggagc acttccctat caggcccaga   1140

ggaggcaggg agtgtgagaa gatacaccac gcacctcgcg ttcagcactc ctgccgaggg   1200

ggcttcctga ggggttccag aggggcccac gtgtccctcc acctcctccc tggcccaggc   1260

tgcagagcct gagctgggac acgccctgaa gcttctggac cctgagagag attgtttctt   1320

ttctttacta tttttttttt tttttttgag acggagtctc actctgtcgc caggctggcg   1380

cgatcttggc tcactgcaac ctctgcctca cgggttcaag cgattttcct gcttcggcct   1440

cctgagtagc tgggactaca ggcacacgcc accatgccca gctcattttt gtatttttag   1500

tagagatggg gtttcaccat gttggccagg atggcctcca tctcttgacc ttgtgatccg   1560

cccgactcgg cctcccaaga tgctgggatt acaggcgtga gccatcaagt ctggcgagag   1620

agattgtttc tagatgaggg tgggggtggg tgtccttagc ccaaagcttg tgccagtctc   1680

tatcagaaat aaatgccccc aaaacctcaa aaaaaaaaaa aaaaaaa                 1727


<210>  2068
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  2068

Met Asn Ala Pro Pro Ala Phe Glu Ser Phe Leu Leu Phe Glu Gly Glu 
1               5                   10                  15      


Lys Ile Thr Ile Asn Lys Asp Thr Lys Val Pro Lys Ala Cys Leu Phe 
            20                  25                  30          


Thr Ile Asn Lys Glu Asp His Thr Leu Gly Asn Ile Ile Lys Ser Gln 
        35                  40                  45              


Leu Leu Lys Asp Pro Gln Val Leu Phe Ala Gly Tyr Lys Val Pro His 
    50                  55                  60                  


Pro Leu Glu His Lys Ile Ile Ile Arg Val Gln Thr Thr Pro Asp Tyr 
65                  70                  75                  80  


Ser Pro Gln Glu Ala Phe Thr Asn Ala Ile Thr Asp Leu Ile Ser Glu 
                85                  90                  95      


Leu Ser Leu Leu Glu Glu Arg Phe Arg Thr Cys Leu Leu Pro Leu Arg 
            100                 105                 110         


Leu Leu Pro 
        115 


<210>  2069
<211>  991
<212>  DNA
<213>  Homosapiens

<400>  2069
acggggggcg atgagccgat ccttgggcgg gtttgccccg ccggagtaat ccggaagagg     60

cctcttatta gggctctggt ggcggcggtg gcggacactt ggggtctgga cgcaacggcg    120

gcgggagcat gaacgcccct ccagccttcg agtcgttctt gctcttcgag ggcgagaaga    180

tcaccattaa caaggacacc aaggtaccca aggcctgctt attcaccatc aacaaagaag    240

accacacact gggaaacatc attaaatcac aactcctaaa agacccgcaa gtgctatttg    300

ctggctacaa agtcccccac cccttggagc acaagatcat catccgagtg cagaccacgc    360

cggactacag cccccaggaa gcctttacca acgccatcac cgacctcatc agtgagctgt    420

ccctgctgga ggagcgcttc cgggtgaggg cggggcctgg aggggcagac ggggtgggct    480

ggacactggc ccgtgtgccc aggcctggga cagccctggc ctgtttcttc ggaggtcctc    540

agggagaggc ggcggtgatg gaagaacagg gacttccacc acaggctcca ggacatgtgg    600

actgaggggc tgtggagtct gggcctgtgg ctcccgtctg ccccatggga cttctgtagt    660

gctgcagggt ccctcgggtg ctgtgggcca gatccgggcg gggacctact gtcctttggg    720

ggtgctcttc tacgtccctt gtcggtgatt ggcaaggcct ggtccttcca ggcctctggg    780

aggcagctca ccccagggtg gcccacacct gttcctagca gggcgcctgg gaatctagaa    840

cagtttagag gggaaagagc cacagcaaag aaaagccgag gcagggtgat cacgaggtca    900

ggagttcaag accagcctgg caaacatggt gaagccctgt ttctactaaa aatacaaaaa    960

ttagctaggc atggtggcat gtgctgtagt c                                   991


<210>  2070
<211>  158
<212>  PRT
<213>  Homosapiens

<400>  2070

Met Asn Ala Pro Pro Ala Phe Glu Ser Phe Leu Leu Phe Glu Gly Glu 
1               5                   10                  15      


Lys Ile Thr Ile Asn Lys Asp Thr Lys Val Pro Lys Ala Cys Leu Phe 
            20                  25                  30          


Thr Ile Asn Lys Glu Asp His Thr Leu Gly Asn Ile Ile Lys Ser Gln 
        35                  40                  45              


Leu Leu Lys Asp Pro Gln Val Leu Phe Ala Gly Tyr Lys Val Pro His 
    50                  55                  60                  


Pro Leu Glu His Lys Ile Ile Ile Arg Val Gln Thr Thr Pro Asp Tyr 
65                  70                  75                  80  


Ser Pro Gln Glu Ala Phe Thr Asn Ala Ile Thr Asp Leu Ile Ser Glu 
                85                  90                  95      


Leu Ser Leu Leu Glu Glu Arg Phe Arg Val Arg Ala Gly Pro Gly Gly 
            100                 105                 110         


Ala Asp Gly Val Gly Trp Thr Leu Ala Arg Val Pro Arg Pro Gly Thr 
        115                 120                 125             


Ala Leu Ala Cys Phe Phe Gly Gly Pro Gln Gly Glu Ala Ala Val Met 
    130                 135                 140                 


Glu Glu Gln Gly Leu Pro Pro Gln Ala Pro Gly His Val Asp 
145                 150                 155             


<210>  2071
<211>  2255
<212>  DNA
<213>  Homosapiens

<400>  2071
cttaggcaag gggtccaggt cagagtttag agctttcaaa tcccaacttg cccctgggga     60

ttgcgcggct gatgtttaga acgcctagtc aagccaaccg gctcgctctt gtttcagcaa    120

accctgactt acgtctccta tttgacttga ggcggcacag tggccaagtc gattggccgt    180

ggcaagtgac cctccctgtg gctgaagtgt tctgaggact ggcgagagag gcgcgccatg    240

cttgccccct gctcaggttg ggagcttggc tgcttccgtc tctgtctccg tcaggtccga    300

ctgtgggctg gcgctgggcg ctgggcttgc tgggcttgcc aagccaggcc gtacagctca    360

ggtgggagcg agcgctggcc cggatcggag actgaggtcc ctccgcctgg cccggcgcgc    420

cgaactctga aggagtggac actgcaggtg agcccgtttg gtcggctgcg ggcgcggctc    480

ccgtgccacc tggccgtgag gcccctggac cccctcacct acccggatgg cgaccgcgtg    540

ctggtcgcgg tgtgcggcgt ggagggcggc gtgcggggcc tggacggcct gcaggtgaag    600

tacgacgagg atctggagga gatggccatt gtgtctgata ctatccaccc ccaggcgtcc    660

gtggaggttt agatatcaag tcatcagggt ctggctgtgt aaaagttcaa agtattgagg    720

gtgataattg caaaattgaa acagagcatg ggactagtat cttgcagtct gttaagggtc    780

aaaaattgca tgttcaaaca aaaggaggca aagtgatctg tctgggaaca gtttatggaa    840

atatagatat tcatgcatca gataaaagtg ctgtgaccat agataaactg cagggaagtt    900

ctgttactgt atctaccgaa gatggtttgc tgaaagccaa gtatctttat acagaatcat    960

catttctgtc ttctgctgct ggggatatta cattaggaag tgttcatggt aatataacat   1020

tacaaagcaa gatgggtaac atcacagtag attcgtcttc tggatgtcta aaagcctcaa   1080

ctaatcaggg tgccatagat gtttatgtca gccaactggg gaaagtggaa ttgaaatccc   1140

ataaaggttc tattattgtc aaggtcccat cttcacttca agctcattta cagttatcag   1200

ggaaagaggt tgatgtgaac tcagaagtcc atgttcagga aatggctgaa gttcgtaaag   1260

atgatgttgt aacagtgact ggactcatga atcaagcaag caaacgtgaa aaatggatta   1320

aggctgatgc cccaaaaggc actgtaagtt ttagaaggca aagttggttt cagtccctga   1380

aactgcagga ctaaaactga tttgagttgg atttatgatt tttaacaatg attcgcagat   1440

ctgtgactac aaaaatgtaa atcccaccat tcatataaag gttgaaaaca acaaattgag   1500

aatgaatact ggtgaactgt tttgggaggc tttttcaaaa tttgtgcttt gctattgtat   1560

tcattttcta ctgctctgta acaaattacc acaaatttag cagcataaaa taatactcat   1620

ttacagctat gtctaggttc tccgctcagg gaatcacaag gctagaaatc aagattttgg   1680

ccaggctgag ttctcatctg gagtctctgg gaagaaatct acttccaact tcattcagat   1740

tattgggaaa atccagttcc ttgtgactgg atgactgagg tctccatttt cttgctggct   1800

gtcagccagc aatcactcta agcttctaga ggccacccac atgccttctc atgttgcccc   1860

tccatcttca agccagcagt gatgcgctga gttcttctca tgctttgaat atctgacttc   1920

ttctgcagcc agctggaaga atatatactt ttaaagggct cacttgatta ggtcaggccc   1980

acccaggata acctttgttt tgccatataa tgtaacattc ataggagtga tggcccatca   2040

cattcagttt tcactcccac tcaaggaaag gagattatac aaaggcatcc atcatgtggg   2100

gacaattagc ttagaattct ttataatgta gctctcacat gacaggtttt ctacttagta   2160

ccttttatgg catcaatgta aatttaagct gtaaataaaa aacaaatatg tgaagcaaaa   2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                              2255


<210>  2072
<211>  144
<212>  PRT
<213>  Homosapiens

<400>  2072

Met Leu Ala Pro Cys Ser Gly Trp Glu Leu Gly Cys Phe Arg Leu Cys 
1               5                   10                  15      


Leu Arg Gln Val Arg Leu Trp Ala Gly Ala Gly Arg Trp Ala Cys Trp 
            20                  25                  30          


Ala Cys Gln Ala Arg Pro Tyr Ser Ser Gly Gly Ser Glu Arg Trp Pro 
        35                  40                  45              


Gly Ser Glu Thr Glu Val Pro Pro Pro Gly Pro Ala Arg Arg Thr Leu 
    50                  55                  60                  


Lys Glu Trp Thr Leu Gln Val Ser Pro Phe Gly Arg Leu Arg Ala Arg 
65                  70                  75                  80  


Leu Pro Cys His Leu Ala Val Arg Pro Leu Asp Pro Leu Thr Tyr Pro 
                85                  90                  95      


Asp Gly Asp Arg Val Leu Val Ala Val Cys Gly Val Glu Gly Gly Val 
            100                 105                 110         


Arg Gly Leu Asp Gly Leu Gln Val Lys Tyr Asp Glu Asp Leu Glu Glu 
        115                 120                 125             


Met Ala Ile Val Ser Asp Thr Ile His Pro Gln Ala Ser Val Glu Val 
    130                 135                 140                 


<210>  2073
<211>  2744
<212>  DNA
<213>  Homosapiens

<400>  2073
agaatgcgag aaagtgaagt caaattcgga cttgtaggcg atcagggctg aagacgctga     60

ttagagagaa aacagagggt gatggtggct gcacgtgggg aatgggtgac atctcccagg    120

gggaatgagc acaaggccca gatcggaaac cccaaactca gattttaagg tttggacaag    180

aagtacctga ggagtggagg agtgagaaag aagtgccaga gagcctgagg aggaaaatca    240

gcagactggc attatgaaga atgttgtcag aagtagggag taggcactag tcacctaaga    300

taaggagctg gattctgccc aaggcactgt tatgtggtat acttgttaca tgtcctgagg    360

atccgctgag gtatttagag ggaatgatca tggttataat caaaagtggt cttcagaatc    420

ttctttgatg actccggaat tgatgataaa agcctgtagc ttttatactg gacatttagt    480

aaagactcat ttttgcactt ggagagacat agctcgtaca aatgaaaatg tcgtcctggc    540

tgaaaaaatg aacagagcag tgacatgcta caatttcaga cttcaaaaat ctgtatttca    600

tcactggcac tcttatatgg aagaccagaa agaaaaactt aaaaatatgc tattgcggat    660

acaacagatc atctattgtc acaagctaac cattatccta acaaaatggc ggaatacagc    720

aagacataag agtaaaaaga aagaagatga gctgatatta aaacatgaac ttcaattgaa    780

aaaatggaaa aataggttaa tactcaaaag agctgctgca gaagaatcca attttcctga    840

acgaagttct tctgaagtct ttcttgtaga tgagactcta aaatgtgaca tttcactgtt    900

acctgaaaga gcaatattac agattttctt ctacctcagt ttaaaagatg tgataatatg    960

tggtcaagtt aatcatgcct ggatgttgat gacacaacta aactcactgt ggaatgctat   1020

tgatttttcc tcagtgaaaa atgtgattcc agataaatat atagtgtcta ctttgcaaag   1080

gtggcgttta aatgtgctgc gtttgaattt tcgtggttgt cttctccgac ccaaaacttt   1140

cagatctgtc agccactgta ggaacttgca agagttgaat gtctctgact gcccaacatt   1200

cacagatgaa tcaatgagac acatttctga gggctgcccg ggggtcctgt gtctcaatct   1260

gtctaacaca actatcacca acaggacgat gcgactcctg ccgaggcact tccacaactt   1320

acagaatctt agtttggctt attgcagacg gttcacagac aaaggcttac agtacctgaa   1380

cttggggaat ggatgccaca agctcatcta tctggacctc tctggctgca cccagatttc   1440

agtccaaggc ttcaggtaca ttgcaaacag ctgcactgga attatgcatc ttaccattaa   1500

tgacatgcca actctgacgg acaactgtgt aaaagcttta gttgaaaaat gctctcgtat   1560

tacatcgctg gttttcactg gtgcaccgca tatctccgat tgtactttca gagctctttc   1620

tgcttgtaaa ctcagaaaga tccgatttga aggaaataaa agggttactg atgcatcctt   1680

caaatttata gacaagaatt atccaaatct cagtcacatt tatatggctg actgcaaggg   1740

aataacagac agcagcctca gatccctttc acctttgaag caactgactg tgttgaattt   1800

ggcaaattgt gtaagaattg gtgatatggg actaaagcaa tttcttgatg gtcctgcaag   1860

catgaggata agagagctaa atttaagcaa ctgtgtgcgg ctaagtgatg cctctgttat   1920

gaaactatct gagcgctgcc ctaatttaaa ctacttgagt ttacgaaatt gtgaacattt   1980

gactgcccaa ggaattggat atattgtaaa catcttttcc ttggtatcaa tagatctctc   2040

tggaacagac atctctaatg agggtttgaa tgtgctttcc agacataaaa aattgaagga   2100

actttctgta tctgaatgtt atagaatcac tgatgatgga attcaggcat tctgcaaaag   2160

ctcactgatc ttggaacatt tggatgtctc ttattgctcc cagctgtcag atatgattat   2220

caaagcactg gccatttact gcattaacct cacatctctc agcattgctg gctgtccaaa   2280

gattactgac tcagcaatgg agatgttatc ggcaaaatgc cattacctgc acattttgga   2340

tatctctggt tgtgtcttgc ttactgacca aatccttgag gaccttcaga taggctgcaa   2400

acaactccgg atccttaaga tgcaatactg cacaaatatt tccaagaagg cagctcaaag   2460

aatgtcatct aaagttcagc agcaggaata caacactaat gaccctccac gttggtttgg   2520

ctatgatagg gaaggaaacc ctgttacaga gcttgacaac ataacatcat ctaaaggagc   2580

cttagaatta acagtgaaaa agtcaacata cagcagtgaa gaccaagcag cgtgaccttc   2640

agcctcaagc aggaagaaca aaaaatcaag aacttggcaa gttttctcca tttgttgcaa   2700

gtatgtttac tagctgaatc tcaataacaa tgtaaacaag caac                    2744


<210>  2074
<211>  735
<212>  PRT
<213>  Homosapiens

<400>  2074

Met Thr Pro Glu Leu Met Ile Lys Ala Cys Ser Phe Tyr Thr Gly His 
1               5                   10                  15      


Leu Val Lys Thr His Phe Cys Thr Trp Arg Asp Ile Ala Arg Thr Asn 
            20                  25                  30          


Glu Asn Val Val Leu Ala Glu Lys Met Asn Arg Ala Val Thr Cys Tyr 
        35                  40                  45              


Asn Phe Arg Leu Gln Lys Ser Val Phe His His Trp His Ser Tyr Met 
    50                  55                  60                  


Glu Asp Gln Lys Glu Lys Leu Lys Asn Met Leu Leu Arg Ile Gln Gln 
65                  70                  75                  80  


Ile Ile Tyr Cys His Lys Leu Thr Ile Ile Leu Thr Lys Trp Arg Asn 
                85                  90                  95      


Thr Ala Arg His Lys Ser Lys Lys Lys Glu Asp Glu Leu Ile Leu Lys 
            100                 105                 110         


His Glu Leu Gln Leu Lys Lys Trp Lys Asn Arg Leu Ile Leu Lys Arg 
        115                 120                 125             


Ala Ala Ala Glu Glu Ser Asn Phe Pro Glu Arg Ser Ser Ser Glu Val 
    130                 135                 140                 


Phe Leu Val Asp Glu Thr Leu Lys Cys Asp Ile Ser Leu Leu Pro Glu 
145                 150                 155                 160 


Arg Ala Ile Leu Gln Ile Phe Phe Tyr Leu Ser Leu Lys Asp Val Ile 
                165                 170                 175     


Ile Cys Gly Gln Val Asn His Ala Trp Met Leu Met Thr Gln Leu Asn 
            180                 185                 190         


Ser Leu Trp Asn Ala Ile Asp Phe Ser Ser Val Lys Asn Val Ile Pro 
        195                 200                 205             


Asp Lys Tyr Ile Val Ser Thr Leu Gln Arg Trp Arg Leu Asn Val Leu 
    210                 215                 220                 


Arg Leu Asn Phe Arg Gly Cys Leu Leu Arg Pro Lys Thr Phe Arg Ser 
225                 230                 235                 240 


Val Ser His Cys Arg Asn Leu Gln Glu Leu Asn Val Ser Asp Cys Pro 
                245                 250                 255     


Thr Phe Thr Asp Glu Ser Met Arg His Ile Ser Glu Gly Cys Pro Gly 
            260                 265                 270         


Val Leu Cys Leu Asn Leu Ser Asn Thr Thr Ile Thr Asn Arg Thr Met 
        275                 280                 285             


Arg Leu Leu Pro Arg His Phe His Asn Leu Gln Asn Leu Ser Leu Ala 
    290                 295                 300                 


Tyr Cys Arg Arg Phe Thr Asp Lys Gly Leu Gln Tyr Leu Asn Leu Gly 
305                 310                 315                 320 


Asn Gly Cys His Lys Leu Ile Tyr Leu Asp Leu Ser Gly Cys Thr Gln 
                325                 330                 335     


Ile Ser Val Gln Gly Phe Arg Tyr Ile Ala Asn Ser Cys Thr Gly Ile 
            340                 345                 350         


Met His Leu Thr Ile Asn Asp Met Pro Thr Leu Thr Asp Asn Cys Val 
        355                 360                 365             


Lys Ala Leu Val Glu Lys Cys Ser Arg Ile Thr Ser Leu Val Phe Thr 
    370                 375                 380                 


Gly Ala Pro His Ile Ser Asp Cys Thr Phe Arg Ala Leu Ser Ala Cys 
385                 390                 395                 400 


Lys Leu Arg Lys Ile Arg Phe Glu Gly Asn Lys Arg Val Thr Asp Ala 
                405                 410                 415     


Ser Phe Lys Phe Ile Asp Lys Asn Tyr Pro Asn Leu Ser His Ile Tyr 
            420                 425                 430         


Met Ala Asp Cys Lys Gly Ile Thr Asp Ser Ser Leu Arg Ser Leu Ser 
        435                 440                 445             


Pro Leu Lys Gln Leu Thr Val Leu Asn Leu Ala Asn Cys Val Arg Ile 
    450                 455                 460                 


Gly Asp Met Gly Leu Lys Gln Phe Leu Asp Gly Pro Ala Ser Met Arg 
465                 470                 475                 480 


Ile Arg Glu Leu Asn Leu Ser Asn Cys Val Arg Leu Ser Asp Ala Ser 
                485                 490                 495     


Val Met Lys Leu Ser Glu Arg Cys Pro Asn Leu Asn Tyr Leu Ser Leu 
            500                 505                 510         


Arg Asn Cys Glu His Leu Thr Ala Gln Gly Ile Gly Tyr Ile Val Asn 
        515                 520                 525             


Ile Phe Ser Leu Val Ser Ile Asp Leu Ser Gly Thr Asp Ile Ser Asn 
    530                 535                 540                 


Glu Gly Leu Asn Val Leu Ser Arg His Lys Lys Leu Lys Glu Leu Ser 
545                 550                 555                 560 


Val Ser Glu Cys Tyr Arg Ile Thr Asp Asp Gly Ile Gln Ala Phe Cys 
                565                 570                 575     


Lys Ser Ser Leu Ile Leu Glu His Leu Asp Val Ser Tyr Cys Ser Gln 
            580                 585                 590         


Leu Ser Asp Met Ile Ile Lys Ala Leu Ala Ile Tyr Cys Ile Asn Leu 
        595                 600                 605             


Thr Ser Leu Ser Ile Ala Gly Cys Pro Lys Ile Thr Asp Ser Ala Met 
    610                 615                 620                 


Glu Met Leu Ser Ala Lys Cys His Tyr Leu His Ile Leu Asp Ile Ser 
625                 630                 635                 640 


Gly Cys Val Leu Leu Thr Asp Gln Ile Leu Glu Asp Leu Gln Ile Gly 
                645                 650                 655     


Cys Lys Gln Leu Arg Ile Leu Lys Met Gln Tyr Cys Thr Asn Ile Ser 
            660                 665                 670         


Lys Lys Ala Ala Gln Arg Met Ser Ser Lys Val Gln Gln Gln Glu Tyr 
        675                 680                 685             


Asn Thr Asn Asp Pro Pro Arg Trp Phe Gly Tyr Asp Arg Glu Gly Asn 
    690                 695                 700                 


Pro Val Thr Glu Leu Asp Asn Ile Thr Ser Ser Lys Gly Ala Leu Glu 
705                 710                 715                 720 


Leu Thr Val Lys Lys Ser Thr Tyr Ser Ser Glu Asp Gln Ala Ala 
                725                 730                 735 


<210>  2075
<211>  1997
<212>  DNA
<213>  Homosapiens

<400>  2075
tgaatgcagc ccattctctg gagaacttcc tcacacacca cagcaaagag aagactgaaa     60

gacaaacctg ggtgcagcca gagaggtcca gatagatgag cttgtggcat ccattcccca    120

agttcagcct agggactcca cgtaccccag ctgggtctca ttgttccaga actgcattag    180

ttaagattac ccagacttgg atttcaaagg aatactttca ttgttccgtc tgtaacacga    240

agtaattggg gccagctgga tgtcaggatg cgtgtggtta ccattgtaat cttgctctgc    300

ttttgcaaag cggctgagct gcgcaaagca agcccaggca gtgtgagaag ccgagtgaat    360

catggccggg cgggtggagg ccggagaggc tccaacccgg tcaaacgcta cgcaccaggc    420

ctcccgtgtg acgtgtacac atatctccat gagaaatact tagattgtca agaaagaaaa    480

ttagtttatg tgctgcctgg ttggcctcag gatttgctgc acatgctgct agcaagaaac    540

aagatccgca cattgaagaa caacatgttt tccaagttta aaaagctgaa aagcctggat    600

ctgcagcaga atgagatctc taaaattgag agtgaggcgt tctttggttt aaacaaactc    660

accaccctct tactgcagca caaccagatc aaagtcttga cggaggaagt gttcatttac    720

acacctctct tgagctacct gcgtctttat gacaacccct ggcactgtac ttgtgagata    780

gaaacgctta tttcaatgtt gcagattccc aggaaccgga atttggggaa ctacgccaag    840

tgtgaaagtc cacaagaaca aaaaaataaa aaactgcggc agataaaatc tgaacagttg    900

tgtaatgaag aagaaaagga acaattggac ccgaaacccc aagtgtcagg gagaccccca    960

gtcatcaagc ctgaggtgga ctcaactttt tgccacaatt atgtgtttcc catacaaaca   1020

ctggactgca aaaggaaaga gttgaaaaaa gtgccaaaca acatccctcc agatattgtt   1080

aaacttgact tgtcatacaa taaaatcaac caacttcgac ccaaggaatt tgaagatgtt   1140

catgagctga agaaattaaa cctcagcagc aatggcattg aattcatcga tcctgccgct   1200

tttttagggc tcacacattt agaagaatta gatttatcaa acaacagtct gcaaaacttt   1260

gactatggcg tattagaaga cttgtatttt ttgaaactct tgtggctcag agataaccct   1320

tggagatgtg actacaacat tcactacctc tactactggt taaagcacca ctacaatgtc   1380

cattttaatg gcctggaatg caaaacgcct gaagaataca aaggatggtc tgtgggaaaa   1440

tatattagaa gttactatga agaatgcccc aaagacaagt taccagcata tcctgagtca   1500

tttgaccaag acacagaaga tgatgaatgg gaaaaaaaac atagagatca caccgcaaag   1560

aagcaaagcg taataattac tatagtagga taaggtagaa attgttctga ttgtaattag   1620

ttttgtattt tctatactgg tgttagaaaa catatgttta catttgatta actgtgttgc   1680

ctatttatgc agggtaatcc agctaaagga agctttcttt aattataagt attattgtga   1740

ctattatagt aatcaagaga atgctatcat cctgcttgcc tgtccatttg tggaacagca   1800

tctggtgata tgcaattcca cactggtaac ctgcagcagt tgggtcctaa tgatggcatt   1860

agactttcat aatgtcctgt ataaatgttt ttactgcttt tagaaaataa agaaaaaaaa   1920

cttggttcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1980

aaaaaaaaaa aaaaaaa                                                  1997


<210>  2076
<211>  441
<212>  PRT
<213>  Homosapiens

<400>  2076

Met Arg Val Val Thr Ile Val Ile Leu Leu Cys Phe Cys Lys Ala Ala 
1               5                   10                  15      


Glu Leu Arg Lys Ala Ser Pro Gly Ser Val Arg Ser Arg Val Asn His 
            20                  25                  30          


Gly Arg Ala Gly Gly Gly Arg Arg Gly Ser Asn Pro Val Lys Arg Tyr 
        35                  40                  45              


Ala Pro Gly Leu Pro Cys Asp Val Tyr Thr Tyr Leu His Glu Lys Tyr 
    50                  55                  60                  


Leu Asp Cys Gln Glu Arg Lys Leu Val Tyr Val Leu Pro Gly Trp Pro 
65                  70                  75                  80  


Gln Asp Leu Leu His Met Leu Leu Ala Arg Asn Lys Ile Arg Thr Leu 
                85                  90                  95      


Lys Asn Asn Met Phe Ser Lys Phe Lys Lys Leu Lys Ser Leu Asp Leu 
            100                 105                 110         


Gln Gln Asn Glu Ile Ser Lys Ile Glu Ser Glu Ala Phe Phe Gly Leu 
        115                 120                 125             


Asn Lys Leu Thr Thr Leu Leu Leu Gln His Asn Gln Ile Lys Val Leu 
    130                 135                 140                 


Thr Glu Glu Val Phe Ile Tyr Thr Pro Leu Leu Ser Tyr Leu Arg Leu 
145                 150                 155                 160 


Tyr Asp Asn Pro Trp His Cys Thr Cys Glu Ile Glu Thr Leu Ile Ser 
                165                 170                 175     


Met Leu Gln Ile Pro Arg Asn Arg Asn Leu Gly Asn Tyr Ala Lys Cys 
            180                 185                 190         


Glu Ser Pro Gln Glu Gln Lys Asn Lys Lys Leu Arg Gln Ile Lys Ser 
        195                 200                 205             


Glu Gln Leu Cys Asn Glu Glu Glu Lys Glu Gln Leu Asp Pro Lys Pro 
    210                 215                 220                 


Gln Val Ser Gly Arg Pro Pro Val Ile Lys Pro Glu Val Asp Ser Thr 
225                 230                 235                 240 


Phe Cys His Asn Tyr Val Phe Pro Ile Gln Thr Leu Asp Cys Lys Arg 
                245                 250                 255     


Lys Glu Leu Lys Lys Val Pro Asn Asn Ile Pro Pro Asp Ile Val Lys 
            260                 265                 270         


Leu Asp Leu Ser Tyr Asn Lys Ile Asn Gln Leu Arg Pro Lys Glu Phe 
        275                 280                 285             


Glu Asp Val His Glu Leu Lys Lys Leu Asn Leu Ser Ser Asn Gly Ile 
    290                 295                 300                 


Glu Phe Ile Asp Pro Ala Ala Phe Leu Gly Leu Thr His Leu Glu Glu 
305                 310                 315                 320 


Leu Asp Leu Ser Asn Asn Ser Leu Gln Asn Phe Asp Tyr Gly Val Leu 
                325                 330                 335     


Glu Asp Leu Tyr Phe Leu Lys Leu Leu Trp Leu Arg Asp Asn Pro Trp 
            340                 345                 350         


Arg Cys Asp Tyr Asn Ile His Tyr Leu Tyr Tyr Trp Leu Lys His His 
        355                 360                 365             


Tyr Asn Val His Phe Asn Gly Leu Glu Cys Lys Thr Pro Glu Glu Tyr 
    370                 375                 380                 


Lys Gly Trp Ser Val Gly Lys Tyr Ile Arg Ser Tyr Tyr Glu Glu Cys 
385                 390                 395                 400 


Pro Lys Asp Lys Leu Pro Ala Tyr Pro Glu Ser Phe Asp Gln Asp Thr 
                405                 410                 415     


Glu Asp Asp Glu Trp Glu Lys Lys His Arg Asp His Thr Ala Lys Lys 
            420                 425                 430         


Gln Ser Val Ile Ile Thr Ile Val Gly 
        435                 440     


<210>  2077
<211>  2002
<212>  DNA
<213>  Homosapiens

<400>  2077
tataacgtga gggctgaatg cagcccattc tctggagaac ttcctcacac accgcagcaa     60

agagaagact gaaagacaaa cctgggtgca gccagagagg tccagataga tgagcttgtg    120

gcatccattc cccaagttca gcctagggac tccacgtacc ccagctgggt ctcattgttc    180

cagaactgca ttagttaaga ttacccagac ttggatttca aaggaatact ttcattgttc    240

cgtctgtaac acgaagtaat tggggccagc tggatgtcag gatgcgtgtg gttaccattg    300

taatcttgct ctgcttttgc aaagcggctg agctgcgcaa agcaagccca ggcagtgtga    360

gaagccgagt gaatcatggc cgggcgggtg gaggccggag aggctccaac ccggtcaaac    420

gctacgcacc aggcctcccg tgtgacgtgt acacatatct ccatgagaaa tacttagatt    480

gtcaagaaag aaaattagtt tatgtgctgc ctggttggcc tcaggatttg ctgcacatgc    540

tgctagcaag aaacaagatc cgcacattga agaacaacat gttttccaag tttaaaaagc    600

tgaaaagcct ggatctgcag cagaatgaga tctctaaaat tgagagtgag gcgttctttg    660

gtttaaacaa actcaccacc ctcttactgc agcacaacca gatcaaagtc ttgacggagg    720

aagtgttcat ttacacacct ctcttgagct acctgcgtct ttatgacaac ccctggcact    780

gtacttgtga gatagaaacg cttatttcaa tgttgcagat tcccaggaac cggaatttgg    840

cgaactacgc caagtgtgaa agtccacaag aacaaaaaaa taaaaaactg cggcagataa    900

aatctgaaca gttgtgtaat gaagaagaaa aggaacaatt ggacccgaaa ccccaagtgt    960

cagggagacc cccagtcatc aagcctgagg tggactcaac tttttgccac aattatgtgt   1020

ttcccataca aacactggac tgcaaaagga aagagttgaa aaaagtgcca aacaacatcc   1080

ctccagatat tgttaaactt gacttgtcat acaataaaat caaccaactt cgacccaagg   1140

aatttgaaga tgttcatgag ctgaagaaat taaacctcag cagcaatggc attgaattca   1200

tcgatcctgg gtctttgaga tgaaaccctg caagtagact tacgtgaatg atttttgctg   1260

tgccgctttt ttagggctca cacatttaga agaattagat ttatcaaaca acagtctgca   1320

aaactttgac tatggcgtat tagaagactt gtattttttg aaactcttgt ggctcagaga   1380

taacccttgg agatgtgact acaacattca ctacctctac tactggttaa agcaccacta   1440

caatgtccat tttaatggcc tggaatgcaa aacgcctgaa gaatacaaag gatggtctgt   1500

gggaaaatat attagaagtt actatgaaga atgccccaaa gacaagttac cagcatatcc   1560

tgagtcattt gaccaagaca cagaagatga tgaatgggaa aaaaaacata gagatcacac   1620

cgcaaagaag caaagcgtaa taattactat agtaggataa ggtagaaatt gttctgattg   1680

taattagttt tgtattttct atactggtgt tagaaaacat atgtttacat ttgattaact   1740

gtgttgccta tttatgcagg gtaatccagc taaaggaagc tttctttaat tataagtatt   1800

attgtgacta ttatagtaat caagagaatg ctatcatcct gcttgcctgt ccatttgtgg   1860

aacagcatct ggtgatatgc aattccacac tggtaacctg cagcagttgg gtcctaatga   1920

tggcattaga ctttcataat gtcctgtata aatgttttta ctgcttttag aaaataaaga   1980

aaaaaaactt ggttcatgtt ta                                            2002


<210>  2078
<211>  313
<212>  PRT
<213>  Homosapiens

<400>  2078

Met Arg Val Val Thr Ile Val Ile Leu Leu Cys Phe Cys Lys Ala Ala 
1               5                   10                  15      


Glu Leu Arg Lys Ala Ser Pro Gly Ser Val Arg Ser Arg Val Asn His 
            20                  25                  30          


Gly Arg Ala Gly Gly Gly Arg Arg Gly Ser Asn Pro Val Lys Arg Tyr 
        35                  40                  45              


Ala Pro Gly Leu Pro Cys Asp Val Tyr Thr Tyr Leu His Glu Lys Tyr 
    50                  55                  60                  


Leu Asp Cys Gln Glu Arg Lys Leu Val Tyr Val Leu Pro Gly Trp Pro 
65                  70                  75                  80  


Gln Asp Leu Leu His Met Leu Leu Ala Arg Asn Lys Ile Arg Thr Leu 
                85                  90                  95      


Lys Asn Asn Met Phe Ser Lys Phe Lys Lys Leu Lys Ser Leu Asp Leu 
            100                 105                 110         


Gln Gln Asn Glu Ile Ser Lys Ile Glu Ser Glu Ala Phe Phe Gly Leu 
        115                 120                 125             


Asn Lys Leu Thr Thr Leu Leu Leu Gln His Asn Gln Ile Lys Val Leu 
    130                 135                 140                 


Thr Glu Glu Val Phe Ile Tyr Thr Pro Leu Leu Ser Tyr Leu Arg Leu 
145                 150                 155                 160 


Tyr Asp Asn Pro Trp His Cys Thr Cys Glu Ile Glu Thr Leu Ile Ser 
                165                 170                 175     


Met Leu Gln Ile Pro Arg Asn Arg Asn Leu Ala Asn Tyr Ala Lys Cys 
            180                 185                 190         


Glu Ser Pro Gln Glu Gln Lys Asn Lys Lys Leu Arg Gln Ile Lys Ser 
        195                 200                 205             


Glu Gln Leu Cys Asn Glu Glu Glu Lys Glu Gln Leu Asp Pro Lys Pro 
    210                 215                 220                 


Gln Val Ser Gly Arg Pro Pro Val Ile Lys Pro Glu Val Asp Ser Thr 
225                 230                 235                 240 


Phe Cys His Asn Tyr Val Phe Pro Ile Gln Thr Leu Asp Cys Lys Arg 
                245                 250                 255     


Lys Glu Leu Lys Lys Val Pro Asn Asn Ile Pro Pro Asp Ile Val Lys 
            260                 265                 270         


Leu Asp Leu Ser Tyr Asn Lys Ile Asn Gln Leu Arg Pro Lys Glu Phe 
        275                 280                 285             


Glu Asp Val His Glu Leu Lys Lys Leu Asn Leu Ser Ser Asn Gly Ile 
    290                 295                 300                 


Glu Phe Ile Asp Pro Gly Ser Leu Arg 
305                 310             


<210>  2079
<211>  2629
<212>  DNA
<213>  Homosapiens

<400>  2079
accgccccgc gctccgctgc caggggcggg agggaggaat ggttgcttca cgccccgggg     60

gaagagacgg gaagctcggc tctgggttgc gggccccggc gtctccgcgt ggggcgcacc    120

gtccgacccc cccctcccgg tgtgcagcgc cccgcaccgc cccgcctcgc ctgggagaag    180

ccgccgggac gcgccgggct ggagtgggcg gttataggct ttgagctagg ccgtttccgg    240

gaggcggagc tcagacccca tttcctttct ccacatccag gtcaggtggc gtttgctgtg    300

gcggctaggc ccgcgtgcgc tggagacctc cgcgctggcc cccgcgagcc tcctgccctg    360

gcccggcgct gcggctctgc cgcggcggca gcatgggtgg cccccggggc gcgggctggg    420

tggcggcggg cctgctgctc ggcgcgggcg cctgctactg catttacagg ctgacccggg    480

gtcggcggcg gggcgaccgc gagctcggga tacgctcttc gaagtccgca ggtgccctgg    540

aagaagggac gtcagagggt cagttgtgcg ggcgctcggc ccggcctcag acgggaggta    600

cctgggagtc acagtggtcc aagacctcgc agcctgaaga cttaactgat ggttcatatg    660

atgatgttct aaatgctgaa caacttcaga aactccttta cctgctggag tcaacggagg    720

atcctgtaat tattgaaaga gctttgatta ctttgggtaa caatgcagcc ttttcagtta    780

accaagctat tattcgtgaa ttgggtggta ttccaattgt tgcaaacaaa atcaaccatt    840

ccaaccagag tattaaagag aaagctttaa atgcactaaa taacctgagt gtgaatgttg    900

aaaatcaaat caagataaag atatacatca gtcaagtatg tgaggatgtc ttctctggtc    960

ctctgaactc tgctgtgcag ctggctggac tgacattgtt gacaaacatg actgttacca   1020

atgaccacca gcacatgctt cacagttaca ttacagacct gttccaggtg ttacttactg   1080

gaaatggaaa cacgaaggtg caagttttga aactgctttt gaatttgtct gaaaatccag   1140

ccatgacaga aggacttctc cgtgcccaag tggattcatc attcctttcc ctttatgaca   1200

gccacgtagc aaaggagatt cttcttcgag tacttacgct atttcagaat ataaagaact   1260

gcctcaaaat agaaggccat ttagctgtgc agcctacttt cactgaaggt tcattgtttt   1320

tcctgttaca tggagaagaa tgtgcccaga aaataagagc tttagttgat caccatgatg   1380

cagaggtgaa ggaaaaggtt gtaacaataa tacccaaaat ctgattggtc atatttttcc   1440

aaagagtaat gcagtctgga tataaatgta ttttctgtct tccttataag gggattctcc   1500

cagctgctaa atttaaacag taaatatcac attttgtcat taacacagct ataacttgcc   1560

gtggttctca gatttatttt ggactatttt gatgccaagt gaatataaga gtttgtactg   1620

aaaccattta tttctttcta ttttgctatt tgcaaatgct tgttatcttc cctacatgaa   1680

gtggcagtaa cctttttcac atttaagcta cccttctacc ttttgaagtg atttgcagtt   1740

actcatctga gacagcatca gtatttgact aaatcattgt ttcacaactg aatagtcttg   1800

ttcttttagt agcaatgaaa tcctaagctc ttgaggccat tcacctgcca acctgaccat   1860

actgctttca aaagtctttt ctcatcagta gaatctattt tggtcacttc tagtcaatga   1920

aaaatgtaaa cttttaggag agaatgtttc ctaggactca cccactccat tcaatgttac   1980

atataaaata gtgtgatcaa tcacaatgtc catctttaga cagttggtta aataaattat   2040

ctggtctttg aaaagaccgt gctgggcgcg gtggctcttg cctgtaatcc cagcactttg   2100

ggaggctgag gcgggcagat cacctgagat cgggagtttg agaccaagcc tgaccaatat   2160

ggagaaaccc tgtctctact aagaatacaa aattagctgg gcatggtggt gcatgcctgt   2220

aatcccagct acttgggagg ccgaggcagg agaattgctt gaacccggga ggcagaggtt   2280

gcagtgaggt gagatagcgc cattgcactc cagcctgggc aacaagagca aaactctgtc   2340

tcaaaaaaaa aaaaaaatga tggagctccg aatgtgctta agtggaaaga tatctatgaa   2400

atatggtggt tttttaaaac acaaaaatta tagaatatgg gatcccgtgt gtgtgtgtgt   2460

gtgtttgaat gaaaaatgct tatgtattga cagaacactt ctagaatgat acccaaactc   2520

ctggagtggg agtggggaat gccttctacg tacacactgt tctactgttt gaatttttta   2580

atatgagccc aaattgtata atcttttttt aataaagggg agaaaaatc               2629


<210>  2080
<211>  343
<212>  PRT
<213>  Homosapiens

<400>  2080

Met Gly Gly Pro Arg Gly Ala Gly Trp Val Ala Ala Gly Leu Leu Leu 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Arg 
            20                  25                  30          


Arg Gly Asp Arg Glu Leu Gly Ile Arg Ser Ser Lys Ser Ala Gly Ala 
        35                  40                  45              


Leu Glu Glu Gly Thr Ser Glu Gly Gln Leu Cys Gly Arg Ser Ala Arg 
    50                  55                  60                  


Pro Gln Thr Gly Gly Thr Trp Glu Ser Gln Trp Ser Lys Thr Ser Gln 
65                  70                  75                  80  


Pro Glu Asp Leu Thr Asp Gly Ser Tyr Asp Asp Val Leu Asn Ala Glu 
                85                  90                  95      


Gln Leu Gln Lys Leu Leu Tyr Leu Leu Glu Ser Thr Glu Asp Pro Val 
            100                 105                 110         


Ile Ile Glu Arg Ala Leu Ile Thr Leu Gly Asn Asn Ala Ala Phe Ser 
        115                 120                 125             


Val Asn Gln Ala Ile Ile Arg Glu Leu Gly Gly Ile Pro Ile Val Ala 
    130                 135                 140                 


Asn Lys Ile Asn His Ser Asn Gln Ser Ile Lys Glu Lys Ala Leu Asn 
145                 150                 155                 160 


Ala Leu Asn Asn Leu Ser Val Asn Val Glu Asn Gln Ile Lys Ile Lys 
                165                 170                 175     


Ile Tyr Ile Ser Gln Val Cys Glu Asp Val Phe Ser Gly Pro Leu Asn 
            180                 185                 190         


Ser Ala Val Gln Leu Ala Gly Leu Thr Leu Leu Thr Asn Met Thr Val 
        195                 200                 205             


Thr Asn Asp His Gln His Met Leu His Ser Tyr Ile Thr Asp Leu Phe 
    210                 215                 220                 


Gln Val Leu Leu Thr Gly Asn Gly Asn Thr Lys Val Gln Val Leu Lys 
225                 230                 235                 240 


Leu Leu Leu Asn Leu Ser Glu Asn Pro Ala Met Thr Glu Gly Leu Leu 
                245                 250                 255     


Arg Ala Gln Val Asp Ser Ser Phe Leu Ser Leu Tyr Asp Ser His Val 
            260                 265                 270         


Ala Lys Glu Ile Leu Leu Arg Val Leu Thr Leu Phe Gln Asn Ile Lys 
        275                 280                 285             


Asn Cys Leu Lys Ile Glu Gly His Leu Ala Val Gln Pro Thr Phe Thr 
    290                 295                 300                 


Glu Gly Ser Leu Phe Phe Leu Leu His Gly Glu Glu Cys Ala Gln Lys 
305                 310                 315                 320 


Ile Arg Ala Leu Val Asp His His Asp Ala Glu Val Lys Glu Lys Val 
                325                 330                 335     


Val Thr Ile Ile Pro Lys Ile 
            340             


<210>  2081
<211>  4841
<212>  DNA
<213>  Homosapiens

<400>  2081
tcatcgctgt cgggaacagc gatgactcga gcgggccgag agtgggtttc ccgtccccga     60

gccctccctc atctcggaga tgccgcactt gtgagcgaca gggcttcatt tgaattttcg    120

cacctcgcga gttgcggagc ctgcatctct gaagctgcct cggtgaagag ccacagcatt    180

attttttttc tctttgggag agtagctgtc tgggatttga gatcctatct tccctgcaaa    240

ttaccaggtt gcatcttcac tgataggaat acatttcttc accaaaggac atggatgaaa    300

atgaaagcaa ccagtctctg atgacaagca gccaatatcc taaagaagca gtaagaaaac    360

gtcaaaattc agcacggaat tccggagcaa gtgattcttc taggttttct aggaaaagct    420

tcaaactgga ttatagacta gaagaagatg taactaaatc caagaaagga aaagatggga    480

gatttgtgaa tccgtggcca acatggaaaa acccctctat tccaaatgtt ctcagatggc    540

tgataatgga gaaagatcac agcagtgttc caagttctaa agaggaacta gacaaagaac    600

tcccagtgct taagccatat tttatcacta accctgaaga agctggagtg agggaagctg    660

gcttaagagt cacatggctg ggacatgcca cggtaatggt ggaaatggat gagctcatat    720

ttctcacgga tcccatcttt agctctcgtg cttcaccatc gcagtacatg ggtccaaagc    780

gatttcgtcg ttccccgtgc acaataagtg aactccctcc aatagatgcg gtccttatca    840

gtcacaacca ctatgaccat ctggactaca attctgtcat tgctttgaat gagcgatttg    900

gtaatgagtt gagatggttt gtgcctttgg gtctccttga ctggatgcaa aaatgtggct    960

gtgagaatgt gattgagttg gactggtggg aggagaattg tgtccccgga catgataagg   1020

tcacttttgt ctttacacct tcccagcact ggtgtaaaag gactctaatg gatgacaaca   1080

aggtgctatg gggcagctgg tctgtcttgg ggccttggaa tcgatttttt ttcgcaggag   1140

atactggtta ttgccctgct tttgaagaga taggaaaaag atttggacct tttgaccttg   1200

cagctattcc catcggagct tatgaaccga ggtggtttat gaaataccag catgtagacc   1260

cagaagaagc tgtaaggatt cacactgatg tccaaacaaa gaaatctatg gcaattcact   1320

ggggaacttt tgccttagca aatgagcatt acttagagcc tccagtgaag ctgaatgaag   1380

ctctagagag atacggactt aacgctgaag atttttttgt cttgaagcat ggagaatcaa   1440

gatacctaaa taataatgat gaaaactttt aataaataat ttcctgaggt gaaaaaccga   1500

tattgaagat tcatttttct tttttccatt cttcaggacc ttcggcaagg tgagtcaagg   1560

ctctctacct acctagatgt ttttcagagg cctacaaata caagtatctt tcttatatgc   1620

acattctaat aaatgatgaa attcagtcca acatgcttat tataaacata gcaattcttg   1680

ctctatcaaa ttagcttata tgccaaatat taaatatggt ttatttaggt aagcataaaa   1740

acataggggc tatcattttt aaagacttga ttttctctat tgtggtaaaa tatataaata   1800

catatttgcc attttaaaca tttaccgttt taaccatttt taagtgtaca gttctttcgc   1860

attaatgcac ccatgaccac cattcactta aatttttaaa agaacagtat attctttttt   1920

tcctagagcc ttcagatgag agggaacagt atattctatt gcacgtctac aattcccaaa   1980

agacctctta ctttgggagg ccaaggtggg tgggtcactt gaacccagga gtttgacatc   2040

aacctgggca acatggtgac ctcccgtctc tctcggaaaa aaaaaaaaga aaaaagaaaa   2100

agccgggtga ggtggtgtgt acctgtagtc acaggtactt gggaggctga ggtgggagga   2160

tcacttgagc ccaggagata gaggctgcag tgagctgtga tcgtaccact gcactccagc   2220

ctgggcgaca aaatgagacc ctgtctcaaa agaaagccct ctccttagct gagcagagga   2280

agggaaggag tgtggctatg agaatatgat ttatgccatt ttctgttttt aaatctagaa   2340

gatcttctaa gcacaaatac agctacaatg aaatatttta cagacaaaat gttaatagac   2400

catattcttt gaattaaatt tgtttttaat tttctctaca catttttttt ttcctggagt   2460

ctcttagctc taaatatatc aatcagattt atattttttt ttacctgatt cagatgtctt   2520

acatttttat attaaatgaa ccttaagcat gattcttttg gtaagccagt atgaatgcca   2580

gtggttgggg ggcggggggg ggagtcagtt gacataagat ttagtcctaa taaggactct   2640

gtattcactt gattattctg acccttccta agggagggag gtggattaga taccactgga   2700

ggcccattct gtattcctaa tccagtctca gcactttatt catacaaaat aatcaaaata   2760

ggttttctac accaaatgct acccaggcag tgctctataa tttatttgca cacctgtatg   2820

tgtggtgcca tgttagccac taaatctgaa cttttaccct gctttcatca tggatttttt   2880

tgtgtaacct gaaacaagtc accaatgctc actgtgcctg tttcctcatt tgcaacaaga   2940

ggataattcc gacctacctc tgaaaaatgt gtagattaaa tgagttttta aagcacttta   3000

gaaaatataa gggagaaaat gatttcttaa gatatcactg cctaatatag acaggtatat   3060

ttgaaagcta aatacaggtt aatgcttttg ataatgtatt gttcctgttg caaatttaag   3120

cattatatat taggagacta aacattgaaa actttcactg atttttaaat tggagtaata   3180

gcctaaataa gtgtaaataa tctttatcaa aatttagtgt ttatctacaa agatgcgaat   3240

cagtcaaggg gaaatgtgta tgcaatgtgt gtgtatatga tgtatgcgaa catatgtgat   3300

tttggggtac taaagcacaa aaaaatcccc cataaaataa accttcctga aaagactgat   3360

cataaacttt ttcactccaa gcagatgtga atcaagatgt taggtttatg gtgagttagc   3420

tttgaggtgt gttgccctaa tactagccag cgttgttgta gccatattcc ctgctgctgc   3480

acgccgaatt gaaaatccat ctcttacctc ttctctatga agcaagccag gtatgtcttg   3540

cttaagtatt tcttctccat gaatggcctt aacattattt tgtattcacg tgtactgttt   3600

aactgagggt ctcaaagcac tttaaactgt tgtgttctat ttccactcgt ctggcctgcc   3660

tcatttttct aggccctttt gtaagctgta attttttatt accactcatg ttctttctac   3720

actgacacta ttcattaaga acatcaagct tcatctctgc ttacagaatc tcaccttatt   3780

gagtgggttc cactttattt ttcatttgtt atctacattt tgaagggttt atgtgcaaag   3840

tgaaaacaaa ttttgaaaaa taagacaaat ccattctctt cttcaattca gtctaatatg   3900

cattgtagtg tcttttaatc agtcttatcc tctaagtcaa cttcattttc ctctttgtga   3960

atacccatag caatatgtaa gattttattg aagtttcctg tgataactga ggaacacttt   4020

gctatgcctc actgcccaat agggtgggtc atcaattagg agaaatccca aattataaaa   4080

gccaacatat gccgtgacct acgtaggaaa agatgtattt gtgcatcttc tttctgggta   4140

gttaaaaatt actccctctt ttctctagca ttttgacatt tcagactcaa tgctctgatc   4200

tctagggagt gtgattattc aaactaatga gaggacaaga agacacagtt ttagaatcta   4260

ctgctgctaa agcacattaa aaacaaatcc tggtttttaa tgtatgcata gtttcatatt   4320

taatgaatat gctttcatta aatagggagg tagatttgaa aaaactgtta taaagaaatg   4380

tgccctttgg ggaatgaata cttttgttca tgtctagccc actgggaatt ttgttttcac   4440

cttatactga gtcctttttc taatgtaaaa atatttcttc caagtttgat ttctgtatca   4500

gggtaacatt gagaacacac atatttctgt ttgaggattt gtgacttcct atggaaacag   4560

tcttgcatct atgtatttac aaatgaaatt taaagtattc ttaaagcttt gccttaaata   4620

ctgcttgcat actgatttac ttaatgctaa gcatggcagg ggttataaat ttaaatacta   4680

taagacctgg ctgaatccca gatgtatcaa taaattgtta tagtagctta tggaaaatgc   4740

tattaaagat aaattttcat acattgtatt tttagtcaag taaaatatgg atgaaaatta   4800

ataaagtact gtcaagggaa aaaataaaaa aaaaaaaaaa a                       4841


<210>  2082
<211>  393
<212>  PRT
<213>  Homosapiens

<400>  2082

Met Asp Glu Asn Glu Ser Asn Gln Ser Leu Met Thr Ser Ser Gln Tyr 
1               5                   10                  15      


Pro Lys Glu Ala Val Arg Lys Arg Gln Asn Ser Ala Arg Asn Ser Gly 
            20                  25                  30          


Ala Ser Asp Ser Ser Arg Phe Ser Arg Lys Ser Phe Lys Leu Asp Tyr 
        35                  40                  45              


Arg Leu Glu Glu Asp Val Thr Lys Ser Lys Lys Gly Lys Asp Gly Arg 
    50                  55                  60                  


Phe Val Asn Pro Trp Pro Thr Trp Lys Asn Pro Ser Ile Pro Asn Val 
65                  70                  75                  80  


Leu Arg Trp Leu Ile Met Glu Lys Asp His Ser Ser Val Pro Ser Ser 
                85                  90                  95      


Lys Glu Glu Leu Asp Lys Glu Leu Pro Val Leu Lys Pro Tyr Phe Ile 
            100                 105                 110         


Thr Asn Pro Glu Glu Ala Gly Val Arg Glu Ala Gly Leu Arg Val Thr 
        115                 120                 125             


Trp Leu Gly His Ala Thr Val Met Val Glu Met Asp Glu Leu Ile Phe 
    130                 135                 140                 


Leu Thr Asp Pro Ile Phe Ser Ser Arg Ala Ser Pro Ser Gln Tyr Met 
145                 150                 155                 160 


Gly Pro Lys Arg Phe Arg Arg Ser Pro Cys Thr Ile Ser Glu Leu Pro 
                165                 170                 175     


Pro Ile Asp Ala Val Leu Ile Ser His Asn His Tyr Asp His Leu Asp 
            180                 185                 190         


Tyr Asn Ser Val Ile Ala Leu Asn Glu Arg Phe Gly Asn Glu Leu Arg 
        195                 200                 205             


Trp Phe Val Pro Leu Gly Leu Leu Asp Trp Met Gln Lys Cys Gly Cys 
    210                 215                 220                 


Glu Asn Val Ile Glu Leu Asp Trp Trp Glu Glu Asn Cys Val Pro Gly 
225                 230                 235                 240 


His Asp Lys Val Thr Phe Val Phe Thr Pro Ser Gln His Trp Cys Lys 
                245                 250                 255     


Arg Thr Leu Met Asp Asp Asn Lys Val Leu Trp Gly Ser Trp Ser Val 
            260                 265                 270         


Leu Gly Pro Trp Asn Arg Phe Phe Phe Ala Gly Asp Thr Gly Tyr Cys 
        275                 280                 285             


Pro Ala Phe Glu Glu Ile Gly Lys Arg Phe Gly Pro Phe Asp Leu Ala 
    290                 295                 300                 


Ala Ile Pro Ile Gly Ala Tyr Glu Pro Arg Trp Phe Met Lys Tyr Gln 
305                 310                 315                 320 


His Val Asp Pro Glu Glu Ala Val Arg Ile His Thr Asp Val Gln Thr 
                325                 330                 335     


Lys Lys Ser Met Ala Ile His Trp Gly Thr Phe Ala Leu Ala Asn Glu 
            340                 345                 350         


His Tyr Leu Glu Pro Pro Val Lys Leu Asn Glu Ala Leu Glu Arg Tyr 
        355                 360                 365             


Gly Leu Asn Ala Glu Asp Phe Phe Val Leu Lys His Gly Glu Ser Arg 
    370                 375                 380                 


Tyr Leu Asn Asn Asn Asp Glu Asn Phe 
385                 390             


<210>  2083
<211>  3677
<212>  DNA
<213>  Homosapiens

<400>  2083
gctgcgcgcg ctggggagca cgtgggggga cacgcaggga ctgcccgcgc gaatggcttc     60

caacgcatgc gccccaccct acatttcaca gtcgccatga cgaccaggag gtccgctagt    120

caacggctcg tcaacggctg cggggacaag tccgttgagg ctgccaggcg agtcaggcct    180

ttctggacct cgcctgactc ggctgggctg tgcctgaaat tgacccagct ccactaggaa    240

ttatgaagaa acaaggactc cgggaagagg tgcacgaact gcaggcgcgg tggttcccca    300

gcagaaccac tctgcatcgg ggaattgaaa acaaggaatt ccccaaccaa acaggggcac    360

aggctgtgtt tgcagctcct gtaaaagctc catacccaga gccgtgtctc ccagctccca    420

gccgtctttg tggcaattct acattggtta catttagtaa cactttttga aaatgatcat    480

catttctctc acctctcatc tttggaacgg gagatgactt tttgcattga aacggttagg    540

tttcttcttc taacgaatta atttgtggtt taagaatagc cagaccgaga ggtgacagca    600

tgctggcagt cctcagagcc cttgcttgct ctcggcacct cccctgcctg ggctcccgct    660

ttggtggcat ttgaggagcc cttcagtccc ccactgcact gtgggagccc ctttctgggc    720

tggccaaggc cggagcccac tccctcagct tgcagggagg tgtggaggga gagacacgag    780

cgggaaccgg ggctgtgtgc tgcacttgcg ggccatctgg agttccgggt gggcgtgggc    840

ttggtgggcc ccgcactcag agcagccagc cagccctgct ggccccgggc aatgggggac    900

ttagcacctg ggccagtggc tgcggagggt gtactgagtc ccccagcagt gctggcccac    960

cggcgctgcg ctcgatttct cgctgggcct tggctgcctt cccacggggc agggctcggg   1020

acctgcagcc cgccatgcct gagcctccta cccaatccat gggctcctgt gcggcctgag   1080

cctccccgac gagcaccacc ccctgctcca cggcgcccag tcccatcgac cacgcaaggg   1140

ctgaggaatg cgagcgcccg gcacaggact ggcaggcagc tccacctgca gccccagtgc   1200

aggatccact aggtgaagcc agctgggctc ctgagtctgg tggggacgtg gagagtcttt   1260

atatctagct cagggattgt aaatacacca atcagcaccc tgtgtttagc tcaaggtttg   1320

tgagtgcacc agtcaacact ctgtatctag ctgctctggt gagggcgtgg agagtcttta   1380

tgtctagctc aaggattgta aatacaccaa tcagcactct gtgtctagct caaggattgt   1440

aaatacacca atcggcactc tgtatctagc tcaaggtttg taaacacacc aatcagcacc   1500

ctgtgtttag ctcaaggttt gtgagtgcac cagtcgacac tctgtatcta gctgccctga   1560

tggggacgtg gagaaccttt gtatctagct cagggattgt aaacgcacca atcagcgccc   1620

tgacgaaaca ggccactcgg ctctaccaat cagcaggatg taggtggggc cagataagag   1680

aataaaagcg ggctgcccga gccagcattg gcaacccgct cgggtcccct tccacactgt   1740

ggaagctttg ttctttcgct ctttgcaata aatcttgcta ctgctcactc tttgggtcca   1800

cgctgctttt gtgagctgta acactcacca tgaagatctg cagcttcact cctgagccca   1860

gcgagaccac gagcccaccg ggaggaacga acaactccag acacgccacc ttaagagctg   1920

taacactcac cgcgagggtc caccgcttca ttcttgaagt cagtgagacc aagaacccac   1980

caattccgga cacaagacta tgagggactt tattattctt acttcaagac cattattgaa   2040

gcaccttcat ttttgggagg actgtggatg attatgaatg acaggcttac tgaatatcct   2100

cttgtaatta atgcagtaaa acgcttccat atttatccag agaattctgg agtccaagga   2160

agaccaagat caaggcgcca gcagatttgg tgtctggtga aggctgctct ccgcttccaa   2220

gatggtgcct tgatgttgca tcttcctgaa ggagaggaac actgtgtcct cacatggcag   2280

acagtaggag agtaatcata gcctcctggt atcgcacatt catgggaata gtgaatttat   2340

ttggactaga aactaagacc tgctggaatg tcaccagaat agaacctctt aatgaagttc   2400

aaagctgtga aggattgcga gatcctgctt gcttttatgt tggtgtaatc tttattttaa   2460

atggactaat gatgggattg ttcttcatat atggaacata cctaagtggt actgaactgg   2520

gaggtcttat tacagtactg tgcttctttt tcaaccatgg agaggccacc tgtgtgatgt   2580

ggacaccacc tctccgtgaa agtttttcct atcctttcct tgtacttcag atgtatgttt   2640

taactttgat tctcaggacc tcaagcaatg atagaaggcc cttcattgca ctctgtcttt   2700

ccaatgttgc ttttatgctt ccctggcaat ttgctcagtt tatacttttt acacagatag   2760

catcattatt tcccatgtat gttgtgggat acattgaacc aagcaaattt cagaagatca   2820

tttatatgaa catgatttca gttaccctta gtttcatttt gatgtttgga aattcaatgt   2880

acttatcttc ttattattct tcatctttgt taatgacatg ggcaataatt ctaaagagaa   2940

atgaaattca aaaactggga gtatctaaac tcaactgctg gctaattcaa ggtagtgcct   3000

ggtggtgtgg aacaatcatt ttgaaatttc tgacatctaa aatcttaggc gtttcagacc   3060

atatttgcct gagtgatctt atagcagccg gaatcttaag gtatacagat tttgatactt   3120

taaaatacac ctgttctccc gaatttgact tcatggaaaa agcgactctg ctgatataca   3180

caaagacatt attgcttcca gttgttatgg tgattacatg ttttatcttt aaaaagactg   3240

ttggtgatat ttcgcgtgtt ttagctacaa acgtttatct aagatgctgt ctttgcaggt   3300

gccatgccta caatggcaag tgtcaagctg tctacacttc atcccattgt gaatcatcca   3360

cattacgaag atgcagactt gaggcctggt tgcagcatgc ttgaaatctg ggatgtggaa   3420

gacccttcca atgcagctaa ccctccctta tgtagcgtcc tccttgagcc gagattgtgc   3480

cactgcactc cagcctgggc gacaaatcaa gaccccgtct ccaaaaaaaa aaaaaaaaaa   3540

acttgattgg gatccaaaat catacaacta tacactaaaa tcagtgaata ttaccttatg   3600

taaattaaaa attaggaaat caaaagaaaa gcatacatat aaaaaacagt tttttctaag   3660

caaaaaaaaa aaaaaaa                                                  3677


<210>  2084
<211>  376
<212>  PRT
<213>  Homosapiens

<400>  2084

Met Ala Asp Ser Arg Arg Val Ile Ile Ala Ser Trp Tyr Arg Thr Phe 
1               5                   10                  15      


Met Gly Ile Val Asn Leu Phe Gly Leu Glu Thr Lys Thr Cys Trp Asn 
            20                  25                  30          


Val Thr Arg Ile Glu Pro Leu Asn Glu Val Gln Ser Cys Glu Gly Leu 
        35                  40                  45              


Arg Asp Pro Ala Cys Phe Tyr Val Gly Val Ile Phe Ile Leu Asn Gly 
    50                  55                  60                  


Leu Met Met Gly Leu Phe Phe Ile Tyr Gly Thr Tyr Leu Ser Gly Thr 
65                  70                  75                  80  


Glu Leu Gly Gly Leu Ile Thr Val Leu Cys Phe Phe Phe Asn His Gly 
                85                  90                  95      


Glu Ala Thr Cys Val Met Trp Thr Pro Pro Leu Arg Glu Ser Phe Ser 
            100                 105                 110         


Tyr Pro Phe Leu Val Leu Gln Met Tyr Val Leu Thr Leu Ile Leu Arg 
        115                 120                 125             


Thr Ser Ser Asn Asp Arg Arg Pro Phe Ile Ala Leu Cys Leu Ser Asn 
    130                 135                 140                 


Val Ala Phe Met Leu Pro Trp Gln Phe Ala Gln Phe Ile Leu Phe Thr 
145                 150                 155                 160 


Gln Ile Ala Ser Leu Phe Pro Met Tyr Val Val Gly Tyr Ile Glu Pro 
                165                 170                 175     


Ser Lys Phe Gln Lys Ile Ile Tyr Met Asn Met Ile Ser Val Thr Leu 
            180                 185                 190         


Ser Phe Ile Leu Met Phe Gly Asn Ser Met Tyr Leu Ser Ser Tyr Tyr 
        195                 200                 205             


Ser Ser Ser Leu Leu Met Thr Trp Ala Ile Ile Leu Lys Arg Asn Glu 
    210                 215                 220                 


Ile Gln Lys Leu Gly Val Ser Lys Leu Asn Cys Trp Leu Ile Gln Gly 
225                 230                 235                 240 


Ser Ala Trp Trp Cys Gly Thr Ile Ile Leu Lys Phe Leu Thr Ser Lys 
                245                 250                 255     


Ile Leu Gly Val Ser Asp His Ile Cys Leu Ser Asp Leu Ile Ala Ala 
            260                 265                 270         


Gly Ile Leu Arg Tyr Thr Asp Phe Asp Thr Leu Lys Tyr Thr Cys Ser 
        275                 280                 285             


Pro Glu Phe Asp Phe Met Glu Lys Ala Thr Leu Leu Ile Tyr Thr Lys 
    290                 295                 300                 


Thr Leu Leu Leu Pro Val Val Met Val Ile Thr Cys Phe Ile Phe Lys 
305                 310                 315                 320 


Lys Thr Val Gly Asp Ile Ser Arg Val Leu Ala Thr Asn Val Tyr Leu 
                325                 330                 335     


Arg Cys Cys Leu Cys Arg Cys His Ala Tyr Asn Gly Lys Cys Gln Ala 
            340                 345                 350         


Val Tyr Thr Ser Ser His Cys Glu Ser Ser Thr Leu Arg Arg Cys Arg 
        355                 360                 365             


Leu Glu Ala Trp Leu Gln His Ala 
    370                 375     


<210>  2085
<211>  3939
<212>  DNA
<213>  Homosapiens

<400>  2085
acatccttca tcctctacct tccttctagc agaaatggcg gctgcggcgg ctcgagtggt     60

gttgtcatcc gcggcgcggc ggcggctctg gggtttcagc gagagtcttc taatccgagg    120

cgctgcggga cggtcattat attttggaga gaacagatta agaagtacac aggctgctac    180

ccaagttgtt ctgaatgttc ctgaaacaag agtaacatgt ttagaaagtg gactcagagt    240

agcttcggaa gactctgggc tctcaacatg cacagttgga ctctggattg atgctggaag    300

tagatacgaa aatgagaaga acaatggaac agcacacttt ctggagcata tggctttcaa    360

gggcaccaag aagagatccc agttagatct ggaacttgag attgaaaata tgggtgctca    420

tctcaatgcc tatacctcca gagagcagac tgtatactat gccaaagcat tctctaaaga    480

cttgccaaga gctgtagaaa ttcttgctga tataatacaa aacagcacat tgggagaagc    540

agagattgaa cgtgagcgtg gagtaatcct tagagagatg caggaagttg aaaccaattt    600

acaagaagtt gtttttgatt atcttcatgc cacagcttat caaaatactg cacttggacg    660

gacaattttg ggaccaactg aaaatatcaa atctataagt cgtaaggact tagtggatta    720

tataaccaca cattataagg ggccaagaat agtgcttgct gctgctggag gtgtttccca    780

tgatgaattg cttgacttag caaagtttca tttcggtgac tctttatgca cacacaaagg    840

agaaatacca gctctgcctc cctgcaaatt cacaggaagt gagattcgtg tgagggatga    900

caagatgcct ttggcgcacc ttgcaatagc tgttgaagct gttggttggg cacatccaga    960

tacaatctgt ctcatggttg caaacacgct gattggcaac tgggatcgct cttttggggg   1020

aggaatgaat ttatctagca agctggccca gctcacttgt catggcaatc tttgccatag   1080

ctttcagtct ttcaacactt cctacacaga tacaggatta tggggactgt atatggtttg   1140

tgaatcatcc actgttgcag acatgctaca tgttgttcaa aaagaatgga tgcgactctg   1200

tacaagtgtc acagaaagtg aggttgcacg agccagaaat cttctgaaaa caaacatgtt   1260

gttgcagctt gatggttcaa ctccaatttg tgaagatatt ggtaggcaaa tgttatgcta   1320

taatagaagg attcccatcc ctgagcttga agcaagaatt gatgctgtga atgctgagac   1380

aattcgagaa gtatgtacca aatacattta taataggagt ccagctattg ctgctgttgg   1440

tcccattaag caactaccag attttaaaca gatacgcagt aacatgtgtt ggcttcgtga   1500

ttaaaatgct cctaatcaag attgtttgaa cacatgtatt tataaaacag agctagagaa   1560

aaataaaaat gaacatgtat atacatttgg aaatttgaat taaatactgt atcatacttt   1620

caaaggataa aaagactacc cctctgaagg ttgttttgta ttaatggtca gtctttgttc   1680

tctgagaaat tatgttggaa gcagcatact ttcaaattat taccatgagt ataattttaa   1740

gaatgaaaat gtttacagta ttttcagttt tattataaaa atgcacacac aacaaagatt   1800

gtcatttctt ggctctactt gcattcagca cttgttcttg agcagctttc tttgctttta   1860

ccatctcgac aagttcctag gaagggagaa aggtgtgatt taagaagttg cgatttaaaa   1920

acagacattt taatctagtg tttggtgtaa agaattcaag caactaagat agatagtact   1980

aaatatactg atttcattat ctgccagggc ctagaaagtt tctaaggttg ctcatttctt   2040

cctcataata ttgaccccat aactactggt tttgaaataa gcactatatt attaaccact   2100

taatagacat aaaatatgag ctatatcacc caagctacaa tttaaaatac aacaatctat   2160

aaacgcttaa gtctgcaacc ttgtatcgtt tcatgcagtc cttctttgtc ctgccaggca   2220

ccgcttctgc tattttttcc catctttcag gtgtatttac tgggtatgtt ttcaaagctt   2280

gttccaaaag cttctgttct tctgttgtcc aaggggtgaa gtctgtatat ggacctgatt   2340

aagaaaaatt tttatttgaa aactgtcttt gaacatgttc tcagacaagt cttgtggtcc   2400

acaagtattc gctaagtgcc catttcaatc tgggatgtgt cattttgaaa ataaacttgt   2460

agagatgaga gatacatata gccctctgag tgttaataag agaaaaaatt tcagatagct   2520

cacatcccag aaaataaaat ctcaaaggct tttaaaacac aatagtaaag atctaccttg   2580

tactgtttat ctcttaaaaa tcaatgtaat acactcacca gactggtaaa aagccatatt   2640

taaatttata gtactgttgg actcttggac tcaaaaacac aaccacaatt cattaagagt   2700

tctgataaat ctacttcctt acagaatagg taaaagagct tcctcacagt taaacttttg   2760

ctggatagaa accctggaaa tcattcttgt tttacactga aggaaacaaa cctagcaaaa   2820

ttaagccaag tgcccaaggt accagtgctg gagaggcaag ctgagattag attgtgttgt   2880

agtgtggtgt tctcttcgtc acatctgcta aaatcttggg agccgatgct gaacacttcc   2940

aataactgct attgtggttc ttcaactaaa ccttgtatat ttcagaaaac atctaagatg   3000

tgtgtcagaa acaaatatgt ttcttaagga tgttaagtat tacacagtcc acttgtgtag   3060

gtaaaagtag aatgttaagt ggtagaaagc tgatttggtt aagttaatgg acttctggca   3120

atttagttat ttcagactat gcagtgacaa cacagactaa tactaccagt agcctgacta   3180

ctactagaaa ctgcggcctg tgagatctgt taaaagttaa gcctagaaac caaagttcct   3240

tcccaattaa agaaggaaaa acaaaacaaa acaaaacaaa accaccacct attcaaaaca   3300

aagcagagaa tttgtataat atttgatggt acctaaggtg cctaagaagc ttttttgaag   3360

gtagctttta agttctagga agtcttttgt tgaatttcct tgtattggtt taaagcccta   3420

aataccatag attttatttc ctctcttgga aaaaagatgg aagtgacatg gcagtatttc   3480

ctgctgttct ccagttactt cacaatacca aaataaatta aacgtactgt tgcaaaactc   3540

ctatgagaaa tcactattca aaaaatggtg ccagcttgct gtttaatggt acaactgaag   3600

aggaaggagc cttcccattt ccataaaaga ggcaaaggag tcatacccac atagcactac   3660

tgccagtcac tcttgccttc acagggtcac ctctcctcac agaaagcaga ctggacaaat   3720

atcagggccc acctccctcc aacatggaaa caagtccccc taagaaagag ctgagactag   3780

tgtgctaata cctgttgtat tttgtggaga taaaggtgca ggagaataaa ctcctttata   3840

aagaagtgtc tttcaggtgt tctgaaaccc tgccttgtta cttaccttta ttaaaagaac   3900

cgaaataatg cctaactcaa aaaaaaaaaa aaaaaaaaa                          3939


<210>  2086
<211>  489
<212>  PRT
<213>  Homosapiens

<400>  2086

Met Ala Ala Ala Ala Ala Arg Val Val Leu Ser Ser Ala Ala Arg Arg 
1               5                   10                  15      


Arg Leu Trp Gly Phe Ser Glu Ser Leu Leu Ile Arg Gly Ala Ala Gly 
            20                  25                  30          


Arg Ser Leu Tyr Phe Gly Glu Asn Arg Leu Arg Ser Thr Gln Ala Ala 
        35                  40                  45              


Thr Gln Val Val Leu Asn Val Pro Glu Thr Arg Val Thr Cys Leu Glu 
    50                  55                  60                  


Ser Gly Leu Arg Val Ala Ser Glu Asp Ser Gly Leu Ser Thr Cys Thr 
65                  70                  75                  80  


Val Gly Leu Trp Ile Asp Ala Gly Ser Arg Tyr Glu Asn Glu Lys Asn 
                85                  90                  95      


Asn Gly Thr Ala His Phe Leu Glu His Met Ala Phe Lys Gly Thr Lys 
            100                 105                 110         


Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn Met Gly Ala 
        115                 120                 125             


His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys 
    130                 135                 140                 


Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu Ala Asp Ile 
145                 150                 155                 160 


Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly 
                165                 170                 175     


Val Ile Leu Arg Glu Met Gln Glu Val Glu Thr Asn Leu Gln Glu Val 
            180                 185                 190         


Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly 
        195                 200                 205             


Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys 
    210                 215                 220                 


Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro Arg Ile Val 
225                 230                 235                 240 


Leu Ala Ala Ala Gly Gly Val Ser His Asp Glu Leu Leu Asp Leu Ala 
                245                 250                 255     


Lys Phe His Phe Gly Asp Ser Leu Cys Thr His Lys Gly Glu Ile Pro 
            260                 265                 270         


Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg Val Arg Asp 
        275                 280                 285             


Asp Lys Met Pro Leu Ala His Leu Ala Ile Ala Val Glu Ala Val Gly 
    290                 295                 300                 


Trp Ala His Pro Asp Thr Ile Cys Leu Met Val Ala Asn Thr Leu Ile 
305                 310                 315                 320 


Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu Ser Ser Lys 
                325                 330                 335     


Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser Phe Gln Ser 
            340                 345                 350         


Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu Tyr Met Val 
        355                 360                 365             


Cys Glu Ser Ser Thr Val Ala Asp Met Leu His Val Val Gln Lys Glu 
    370                 375                 380                 


Trp Met Arg Leu Cys Thr Ser Val Thr Glu Ser Glu Val Ala Arg Ala 
385                 390                 395                 400 


Arg Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp Gly Ser Thr 
                405                 410                 415     


Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg 
            420                 425                 430         


Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val Asn Ala Glu 
        435                 440                 445             


Thr Ile Arg Glu Val Cys Thr Lys Tyr Ile Tyr Asn Arg Ser Pro Ala 
    450                 455                 460                 


Ile Ala Ala Val Gly Pro Ile Lys Gln Leu Pro Asp Phe Lys Gln Ile 
465                 470                 475                 480 


Arg Ser Asn Met Cys Trp Leu Arg Asp 
                485                 


<210>  2087
<211>  1545
<212>  DNA
<213>  Homosapiens

<400>  2087
gaagacacca ccggaagcaa ggaaggtgct gtgtaatcat taaggagcgg aggcttttgg     60

agctgctaaa atgccggatt acctcggtgc cgatcagcgg aagaccaaag aggatgagaa    120

ggacgacaag cccatccgag ctctggatga gggggatatt gccttgttga aaacttatgg    180

tcagagcact tactctaggc agatcaagca agttgaagat gacattcagc aacttctcaa    240

gaaaattaat gagctcactg gtattaaaga atctgacact ggcctggccc caccagcact    300

ctgggatttg gctgcagata agcagacact ccagagtgaa cagcctttac aggttgccag    360

gtgtacaaag ataatcaatg ctgattcgga ggacccaaaa tacattatca acgtaaagca    420

gtttgccaag tttgtggtgg accttagtga tcaggtggca cctactgaca ttgaagaagg    480

gatgagagtg ggcgtggata gaaataaata tcaaattcac attccattgc ctcctaagat    540

tgacccaaca gttaccatga tgcaggtgga agagaaacct gatgtcacat acagtgatgt    600

tggtggctgt aaggaacaga ttgagaaact gcgagaagta gttgaaaccc cattacttca    660

tccagagagg tttgtgaacc ttggcattga gcctcccaag ggcgtgctgc tctttggtcc    720

acccggtaca ggcaagacac tctgtgcgcg ggcagttgct aatcggactg atgcgtgctt    780

cattcgagtt attggatctg agcttgtaca gaaatacgtc ggtgaggggg ctcgaatggt    840

tcgtgaactc tttgaaatgg ccagaacaaa aaaagcctgc cttatcttct ttgatgaaat    900

tgatgctatt ggaggggctc gttttgatga tggtgctgga ggtgacaatg aagtgcagag    960

aacaatgttg gaactgatca atcagcttga tggttttgat cctcgaggca atattaaagt   1020

gctgatggcc actaacagac ctgatacttt ggatccagca ctgatgaggc cagggagatt   1080

ggatagaaaa attgaattta gcttgcccga tctagagggt cggacccaca tatttaagat   1140

tcacgctcgt tcaatgagtg ttgaaagaga tatcagattt gaactgttag cacgactgtg   1200

tccaaatagc actggtgctg agattagaag cgtctgcaca gaggctggta tgtttgccat   1260

cagagcacgg cgaaaaattg ctaccgagaa ggatttcttg gaagctgtaa ataaggtcat   1320

taagtcttat gccaaattca gtgctactcc tcgttacatg acatacaact gaaccctgaa   1380

ggctttcaag tgaaaacttt aaattggaat cctaacctta tatagacttg ttaataacca   1440

attcataaac aaataaatgg cttcaaaatt gtatgctttt ttccatatct cttcttgtaa   1500

tataataaaa ggtgatttct aatgttaaaa aaaaaaaaaa aaaaa                   1545


<210>  2088
<211>  433
<212>  PRT
<213>  Homosapiens

<400>  2088

Met Pro Asp Tyr Leu Gly Ala Asp Gln Arg Lys Thr Lys Glu Asp Glu 
1               5                   10                  15      


Lys Asp Asp Lys Pro Ile Arg Ala Leu Asp Glu Gly Asp Ile Ala Leu 
            20                  25                  30          


Leu Lys Thr Tyr Gly Gln Ser Thr Tyr Ser Arg Gln Ile Lys Gln Val 
        35                  40                  45              


Glu Asp Asp Ile Gln Gln Leu Leu Lys Lys Ile Asn Glu Leu Thr Gly 
    50                  55                  60                  


Ile Lys Glu Ser Asp Thr Gly Leu Ala Pro Pro Ala Leu Trp Asp Leu 
65                  70                  75                  80  


Ala Ala Asp Lys Gln Thr Leu Gln Ser Glu Gln Pro Leu Gln Val Ala 
                85                  90                  95      


Arg Cys Thr Lys Ile Ile Asn Ala Asp Ser Glu Asp Pro Lys Tyr Ile 
            100                 105                 110         


Ile Asn Val Lys Gln Phe Ala Lys Phe Val Val Asp Leu Ser Asp Gln 
        115                 120                 125             


Val Ala Pro Thr Asp Ile Glu Glu Gly Met Arg Val Gly Val Asp Arg 
    130                 135                 140                 


Asn Lys Tyr Gln Ile His Ile Pro Leu Pro Pro Lys Ile Asp Pro Thr 
145                 150                 155                 160 


Val Thr Met Met Gln Val Glu Glu Lys Pro Asp Val Thr Tyr Ser Asp 
                165                 170                 175     


Val Gly Gly Cys Lys Glu Gln Ile Glu Lys Leu Arg Glu Val Val Glu 
            180                 185                 190         


Thr Pro Leu Leu His Pro Glu Arg Phe Val Asn Leu Gly Ile Glu Pro 
        195                 200                 205             


Pro Lys Gly Val Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr Leu 
    210                 215                 220                 


Cys Ala Arg Ala Val Ala Asn Arg Thr Asp Ala Cys Phe Ile Arg Val 
225                 230                 235                 240 


Ile Gly Ser Glu Leu Val Gln Lys Tyr Val Gly Glu Gly Ala Arg Met 
                245                 250                 255     


Val Arg Glu Leu Phe Glu Met Ala Arg Thr Lys Lys Ala Cys Leu Ile 
            260                 265                 270         


Phe Phe Asp Glu Ile Asp Ala Ile Gly Gly Ala Arg Phe Asp Asp Gly 
        275                 280                 285             


Ala Gly Gly Asp Asn Glu Val Gln Arg Thr Met Leu Glu Leu Ile Asn 
    290                 295                 300                 


Gln Leu Asp Gly Phe Asp Pro Arg Gly Asn Ile Lys Val Leu Met Ala 
305                 310                 315                 320 


Thr Asn Arg Pro Asp Thr Leu Asp Pro Ala Leu Met Arg Pro Gly Arg 
                325                 330                 335     


Leu Asp Arg Lys Ile Glu Phe Ser Leu Pro Asp Leu Glu Gly Arg Thr 
            340                 345                 350         


His Ile Phe Lys Ile His Ala Arg Ser Met Ser Val Glu Arg Asp Ile 
        355                 360                 365             


Arg Phe Glu Leu Leu Ala Arg Leu Cys Pro Asn Ser Thr Gly Ala Glu 
    370                 375                 380                 


Ile Arg Ser Val Cys Thr Glu Ala Gly Met Phe Ala Ile Arg Ala Arg 
385                 390                 395                 400 


Arg Lys Ile Ala Thr Glu Lys Asp Phe Leu Glu Ala Val Asn Lys Val 
                405                 410                 415     


Ile Lys Ser Tyr Ala Lys Phe Ser Ala Thr Pro Arg Tyr Met Thr Tyr 
            420                 425                 430         


Asn 
    


<210>  2089
<211>  2671
<212>  DNA
<213>  Homosapiens

<400>  2089
aggcagcggc tgtggagcgc ggcggggcgg ctccgcccag ggcagcccgg gctgggccaa     60

ggagcgagct ctcccttctc ctgctctcag cctcagtgat caaggcttca gtgaactgca    120

ctggagctcc cagcggggga tcttgtcccc tgtcccgact tttgtgctgc acattggatc    180

tggtgacact caggaaatgc ttgtctccgg ctgttaagga ataatttcag agtactatgg    240

atcatgctga agaaaatgaa atccttgcag caacccagag gtactatgtg gaaaggccta    300

tctttagtca tccggtcctc caggaaagac tacacacaaa ggacaaggtt cctgattcca    360

ttgcggataa gctgaaacag gcattcacat gtactcctaa aaaaataaga aatatcattt    420

atatgttcct acccataact aaatggctgc cagcatacaa attcaaggaa tatgtgttgg    480

gtgacttggt ctcaggcata agcacagggg tgcttcagct tcctcaaggc ttagcctttg    540

caatgctggc agctgtgcct ccaatatttg gcctgtactc ttcattttac cctgttatca    600

tgtattgttt tcttggaacc tccagacaca tatccatagg tccttttgct gttattagcc    660

tgatgattgg tggtgtagct gttcgattag taccagatga tatagtcatt ccaggaggag    720

taaatgcaac caatggcaca gaggccagag atgccttgag agtgaaagtc gccatgtctg    780

tgaccttact ttcaggaatc attcagtttt gcctaggtgt ctgtaggttt ggatttgtgg    840

ccatatatct cacagagcct ctggtccgtg ggtttaccac cgcagcagct gtgcatgtct    900

tcacctccat gttaaaatat ctgtttggag ttaaaacaaa gcggtacagt ggaatctttt    960

ccgtggtgta tagtacagtt gctgtgttgc agaatgttaa aaacctcaac gtgtgttccc   1020

taggcgtcgg gctgatggtt tttggtttgc tgttgggtgg caaggagttt aatgagagat   1080

ttaaagagaa attgccggcg cctattcctt tagagttctt tgcggtcgta atgggaactg   1140

gcatttcagc tgggtttaac ttgaaagaat catacaatgt ggatgtcgtt ggaacacttc   1200

ctctagggct gctacctcca gccaatccgg acaccagcct cttccacctt gtgtacgtag   1260

atgccattgc catagccatc gttggatttt cagtgaccat ctccatggcc aagaccttag   1320

caaataaaca tggctaccag gttgacggca atcaggagct cattgccctg ggactgtgca   1380

attccattgg ctcactcttc cagacctttt caatttcatg ctccttgtct cgaagccttg   1440

ttcaggaggg aaccggtggg aagacacagc ttgcaggttg tttggcctca ttaatgattc   1500

tgctggtcat attagcaact ggattcctct ttgaatcatt gccccaggct gtgctgtcgg   1560

ccattgtgat tgtcaacctg aagggaatgt ttatgcagtt ctcagatctc ccctttttct   1620

ggagaaccag caaaatagag ctgaccatct ggcttaccac ttttgtgtcc tccttgttcc   1680

tgggattgga ctatggtttg atcactgctg tgatcattgc tctgctgact gtgatttaca   1740

gaacacagag tccaagctac aaagtccttg gaaagcttcc tgaaactgat gtgtatattg   1800

atatagacgc atatgaggag gtgaaagaaa ttcctggaat aaaaatattt caaataaatg   1860

caccaattta ctatgcaaat agcgacttgt atagcaatgc attaaaacga aagactggag   1920

tgaacccagc agtcatcatg ggagcaagga gaaaggccat gcggaagtac gctaaggaag   1980

tcggaaatgc aaatatggcc aacgcaactg ttgtcaaagc agatgcagaa gtagatggag   2040

aggatgctac caagcctgaa gaagaggatg gtgaagtaaa atatccccca atagtgatca   2100

aaagcacatt tcctgaggaa atgcaaagat ttatgccccc aggggataac gtccacactg   2160

tcattttgga tttcactcaa gtcaatttta ttgattctgt tggagtgaaa actctggcag   2220

ggattgtaaa agaatatgga gacgtcggta tatatgtata cttagcagga tgcagtgcac   2280

aagttgtgaa tgacctcact cggaatagat tttttgaaaa tcctgcccta tgggagctgc   2340

tgttccacag cattcatgat gcagttttag gcagccaact tagagaggca cttgctgaac   2400

aggaagcctc ggctccccct tcccaggagg acttggagcc caatgccact cctgccactc   2460

ctgaggcata gatgaggacc tcaccctagg atggggttat aagcctctca tgaagttcat   2520

aatttacacg ttttaaatac tagacgctag attttttttt ctaagggtga atactagtag   2580

tccaggcttg atttggaggg tgaatgacgc ctagcaagat gtattgtact tgtgtttttt   2640

taattgaata cttcaaagat aaaaaaaaaa a                                  2671


<210>  2090
<211>  744
<212>  PRT
<213>  Homosapiens

<400>  2090

Met Asp His Ala Glu Glu Asn Glu Ile Leu Ala Ala Thr Gln Arg Tyr 
1               5                   10                  15      


Tyr Val Glu Arg Pro Ile Phe Ser His Pro Val Leu Gln Glu Arg Leu 
            20                  25                  30          


His Thr Lys Asp Lys Val Pro Asp Ser Ile Ala Asp Lys Leu Lys Gln 
        35                  40                  45              


Ala Phe Thr Cys Thr Pro Lys Lys Ile Arg Asn Ile Ile Tyr Met Phe 
    50                  55                  60                  


Leu Pro Ile Thr Lys Trp Leu Pro Ala Tyr Lys Phe Lys Glu Tyr Val 
65                  70                  75                  80  


Leu Gly Asp Leu Val Ser Gly Ile Ser Thr Gly Val Leu Gln Leu Pro 
                85                  90                  95      


Gln Gly Leu Ala Phe Ala Met Leu Ala Ala Val Pro Pro Ile Phe Gly 
            100                 105                 110         


Leu Tyr Ser Ser Phe Tyr Pro Val Ile Met Tyr Cys Phe Leu Gly Thr 
        115                 120                 125             


Ser Arg His Ile Ser Ile Gly Pro Phe Ala Val Ile Ser Leu Met Ile 
    130                 135                 140                 


Gly Gly Val Ala Val Arg Leu Val Pro Asp Asp Ile Val Ile Pro Gly 
145                 150                 155                 160 


Gly Val Asn Ala Thr Asn Gly Thr Glu Ala Arg Asp Ala Leu Arg Val 
                165                 170                 175     


Lys Val Ala Met Ser Val Thr Leu Leu Ser Gly Ile Ile Gln Phe Cys 
            180                 185                 190         


Leu Gly Val Cys Arg Phe Gly Phe Val Ala Ile Tyr Leu Thr Glu Pro 
        195                 200                 205             


Leu Val Arg Gly Phe Thr Thr Ala Ala Ala Val His Val Phe Thr Ser 
    210                 215                 220                 


Met Leu Lys Tyr Leu Phe Gly Val Lys Thr Lys Arg Tyr Ser Gly Ile 
225                 230                 235                 240 


Phe Ser Val Val Tyr Ser Thr Val Ala Val Leu Gln Asn Val Lys Asn 
                245                 250                 255     


Leu Asn Val Cys Ser Leu Gly Val Gly Leu Met Val Phe Gly Leu Leu 
            260                 265                 270         


Leu Gly Gly Lys Glu Phe Asn Glu Arg Phe Lys Glu Lys Leu Pro Ala 
        275                 280                 285             


Pro Ile Pro Leu Glu Phe Phe Ala Val Val Met Gly Thr Gly Ile Ser 
    290                 295                 300                 


Ala Gly Phe Asn Leu Lys Glu Ser Tyr Asn Val Asp Val Val Gly Thr 
305                 310                 315                 320 


Leu Pro Leu Gly Leu Leu Pro Pro Ala Asn Pro Asp Thr Ser Leu Phe 
                325                 330                 335     


His Leu Val Tyr Val Asp Ala Ile Ala Ile Ala Ile Val Gly Phe Ser 
            340                 345                 350         


Val Thr Ile Ser Met Ala Lys Thr Leu Ala Asn Lys His Gly Tyr Gln 
        355                 360                 365             


Val Asp Gly Asn Gln Glu Leu Ile Ala Leu Gly Leu Cys Asn Ser Ile 
    370                 375                 380                 


Gly Ser Leu Phe Gln Thr Phe Ser Ile Ser Cys Ser Leu Ser Arg Ser 
385                 390                 395                 400 


Leu Val Gln Glu Gly Thr Gly Gly Lys Thr Gln Leu Ala Gly Cys Leu 
                405                 410                 415     


Ala Ser Leu Met Ile Leu Leu Val Ile Leu Ala Thr Gly Phe Leu Phe 
            420                 425                 430         


Glu Ser Leu Pro Gln Ala Val Leu Ser Ala Ile Val Ile Val Asn Leu 
        435                 440                 445             


Lys Gly Met Phe Met Gln Phe Ser Asp Leu Pro Phe Phe Trp Arg Thr 
    450                 455                 460                 


Ser Lys Ile Glu Leu Thr Ile Trp Leu Thr Thr Phe Val Ser Ser Leu 
465                 470                 475                 480 


Phe Leu Gly Leu Asp Tyr Gly Leu Ile Thr Ala Val Ile Ile Ala Leu 
                485                 490                 495     


Leu Thr Val Ile Tyr Arg Thr Gln Ser Pro Ser Tyr Lys Val Leu Gly 
            500                 505                 510         


Lys Leu Pro Glu Thr Asp Val Tyr Ile Asp Ile Asp Ala Tyr Glu Glu 
        515                 520                 525             


Val Lys Glu Ile Pro Gly Ile Lys Ile Phe Gln Ile Asn Ala Pro Ile 
    530                 535                 540                 


Tyr Tyr Ala Asn Ser Asp Leu Tyr Ser Asn Ala Leu Lys Arg Lys Thr 
545                 550                 555                 560 


Gly Val Asn Pro Ala Val Ile Met Gly Ala Arg Arg Lys Ala Met Arg 
                565                 570                 575     


Lys Tyr Ala Lys Glu Val Gly Asn Ala Asn Met Ala Asn Ala Thr Val 
            580                 585                 590         


Val Lys Ala Asp Ala Glu Val Asp Gly Glu Asp Ala Thr Lys Pro Glu 
        595                 600                 605             


Glu Glu Asp Gly Glu Val Lys Tyr Pro Pro Ile Val Ile Lys Ser Thr 
    610                 615                 620                 


Phe Pro Glu Glu Met Gln Arg Phe Met Pro Pro Gly Asp Asn Val His 
625                 630                 635                 640 


Thr Val Ile Leu Asp Phe Thr Gln Val Asn Phe Ile Asp Ser Val Gly 
                645                 650                 655     


Val Lys Thr Leu Ala Gly Ile Val Lys Glu Tyr Gly Asp Val Gly Ile 
            660                 665                 670         


Tyr Val Tyr Leu Ala Gly Cys Ser Ala Gln Val Val Asn Asp Leu Thr 
        675                 680                 685             


Arg Asn Arg Phe Phe Glu Asn Pro Ala Leu Trp Glu Leu Leu Phe His 
    690                 695                 700                 


Ser Ile His Asp Ala Val Leu Gly Ser Gln Leu Arg Glu Ala Leu Ala 
705                 710                 715                 720 


Glu Gln Glu Ala Ser Ala Pro Pro Ser Gln Glu Asp Leu Glu Pro Asn 
                725                 730                 735     


Ala Thr Pro Ala Thr Pro Glu Ala 
            740                 


<210>  2091
<211>  2492
<212>  DNA
<213>  Homosapiens

<400>  2091
aggcagcggc tgtggagcgc ggcggggcgg ctccgcccag ggcagcccgg gctgggccaa     60

ggagcgagct ctcccttctc ctgctctcag cctcagtgat caaggcttca gtgaactgca    120

ctggagctcc cagcggggga tcttgtcccc tgtcccgact tttgtgctgc acattggatc    180

tggtgacact caggaaatgc ttgtctccgg ctgttaagga ataatttcag agtactatgg    240

atcatgctga agaaaatgaa atccttgcag caacccagag gtactatgtg gaaaggccta    300

tctttagtca tccggtcctc caggaaagac tacacacaaa ggacaaggtt cctgattcca    360

ttgcggataa gctgaaacag gcattcacat gtactcctaa aaaaataaga aatatcattt    420

atatgttcct acccataact aaatggctgc cagcatacaa attcaaggaa tatgtgttgg    480

gtgacttggt ctcaggcata agcacagggg tgcttcagct tcctcaaggc ttagcctttg    540

caatgctggc agctgtgcct ccaatatttg gcctgtactc ttcattttac cctgttatca    600

tgtattgttt tcttggaacc tccagacaca tatccatagg tccttttgct gttattagcc    660

tgatgattgg tggtgtagct gttcgattag taccagatga tatagtcatt ccaggaggag    720

taaatgcaac caatggcaca gaggccagag atgccttgag agtgaaagtc gccatgtctg    780

tgaccttact ttcaggaatc attcagtttt gcctaggtgt ctgtaggttt ggatttgtgg    840

ccatatatct cacagagcct ctggtccgtg ggtttaccac cgcagcagct gtgcatgtct    900

tcacctccat gttaaaatat ctgtttggag ttaaaacaaa gcggtacagt ggaatctttt    960

ccgtggtgta tagtacagtt gctgtgttgc agaatgttaa aaacctcaac gtgtgttccc   1020

taggcgtcgg gctgatggtt tttggtttgc tgttgggtgg caaggagttt aatgagagat   1080

ttaaagagaa attgccggcg cctattcctt tagagttctt tgcggtcgta atgggaactg   1140

gcatttcagc tgggtttaac ttgaaagaat catacaatgt ggatgtcgtt ggaacacttc   1200

ctctagggct gctacctcca gccaatccgg acaccagcct cttccacctt gtgtacgtag   1260

atgccattgc catagccatc gttggatttt cagtgaccat ctccatggcc aagaccttag   1320

caaataaaca tggctaccag gttgacggca atcaggagct cattgccctg ggactgtgca   1380

attccattgg ctcactcttc cagacctttt caatttcatg ctccttgtct cgaagccttg   1440

ttcaggaggg aaccggtggg aagacacagc ttgcaggttg tttggcctca ttaatgattc   1500

tgctggtcat attagcaact ggattcctct ttgaatcatt gccccaggct gtgctgtcgg   1560

ccattgtgat tgtcaacctg aagggaatgt ttatgcagtt ctcagatctc ccctttttct   1620

ggagaaccag caaaatagag ctgaccatct ggcttaccac ttttgtgtcc tccttgttcc   1680

tgggattgga ctatggtttg atcactgctg tgatcattgc tctgctgact gtgatttaca   1740

gaacacagag tccaagctac aaagtccttg gaaagcttcc tgaaactgat gtgtatattg   1800

atatagacgc atatgaggag gtgaaagaaa ttcctggaat aaaaatattt caaataaatg   1860

caccaattta ctatgcaaat agcgacttgt atagcaatgc attaaaacga aagactggag   1920

tgaacccagc agtcatcatg ggagcaagga gaaaggccat gcggaagtac gctaaggaag   1980

tcggaaatgc aaatatggcc aacgcaactg ttgtcaaagc agatgcagaa gtagatggag   2040

aggatgctac caagcctgaa gaagaggatg gtgaagtaaa atatccccca atagtgatca   2100

aaagcacatt tcctgaggaa atgcaaagat ttatgccccc aggggataac gtccacactg   2160

tcattttgga tttcactcaa gtcaatttta ttgattctgt tggagtgaaa actctggcag   2220

ggattgtaaa agaatatgga gacgtcggta tatatgtata cttagcagga tgcagtgctt   2280

tcatacagag atgaccagaa gatggagacc gtaggggaaa tgccgtgtaa tccaagcagt   2340

tcaggctttg gggccaggtg gacagggttt gaatgccagc tctggaatct gttagtgggg   2400

tgacctcagc caagtcactt aacacttctg aactttgttt tctcttttgt gaaataaaga   2460

aaaaatgaat ctacaaaaaa aaaaaaaaaa aa                                 2492


<210>  2092
<211>  685
<212>  PRT
<213>  Homosapiens

<400>  2092

Met Asp His Ala Glu Glu Asn Glu Ile Leu Ala Ala Thr Gln Arg Tyr 
1               5                   10                  15      


Tyr Val Glu Arg Pro Ile Phe Ser His Pro Val Leu Gln Glu Arg Leu 
            20                  25                  30          


His Thr Lys Asp Lys Val Pro Asp Ser Ile Ala Asp Lys Leu Lys Gln 
        35                  40                  45              


Ala Phe Thr Cys Thr Pro Lys Lys Ile Arg Asn Ile Ile Tyr Met Phe 
    50                  55                  60                  


Leu Pro Ile Thr Lys Trp Leu Pro Ala Tyr Lys Phe Lys Glu Tyr Val 
65                  70                  75                  80  


Leu Gly Asp Leu Val Ser Gly Ile Ser Thr Gly Val Leu Gln Leu Pro 
                85                  90                  95      


Gln Gly Leu Ala Phe Ala Met Leu Ala Ala Val Pro Pro Ile Phe Gly 
            100                 105                 110         


Leu Tyr Ser Ser Phe Tyr Pro Val Ile Met Tyr Cys Phe Leu Gly Thr 
        115                 120                 125             


Ser Arg His Ile Ser Ile Gly Pro Phe Ala Val Ile Ser Leu Met Ile 
    130                 135                 140                 


Gly Gly Val Ala Val Arg Leu Val Pro Asp Asp Ile Val Ile Pro Gly 
145                 150                 155                 160 


Gly Val Asn Ala Thr Asn Gly Thr Glu Ala Arg Asp Ala Leu Arg Val 
                165                 170                 175     


Lys Val Ala Met Ser Val Thr Leu Leu Ser Gly Ile Ile Gln Phe Cys 
            180                 185                 190         


Leu Gly Val Cys Arg Phe Gly Phe Val Ala Ile Tyr Leu Thr Glu Pro 
        195                 200                 205             


Leu Val Arg Gly Phe Thr Thr Ala Ala Ala Val His Val Phe Thr Ser 
    210                 215                 220                 


Met Leu Lys Tyr Leu Phe Gly Val Lys Thr Lys Arg Tyr Ser Gly Ile 
225                 230                 235                 240 


Phe Ser Val Val Tyr Ser Thr Val Ala Val Leu Gln Asn Val Lys Asn 
                245                 250                 255     


Leu Asn Val Cys Ser Leu Gly Val Gly Leu Met Val Phe Gly Leu Leu 
            260                 265                 270         


Leu Gly Gly Lys Glu Phe Asn Glu Arg Phe Lys Glu Lys Leu Pro Ala 
        275                 280                 285             


Pro Ile Pro Leu Glu Phe Phe Ala Val Val Met Gly Thr Gly Ile Ser 
    290                 295                 300                 


Ala Gly Phe Asn Leu Lys Glu Ser Tyr Asn Val Asp Val Val Gly Thr 
305                 310                 315                 320 


Leu Pro Leu Gly Leu Leu Pro Pro Ala Asn Pro Asp Thr Ser Leu Phe 
                325                 330                 335     


His Leu Val Tyr Val Asp Ala Ile Ala Ile Ala Ile Val Gly Phe Ser 
            340                 345                 350         


Val Thr Ile Ser Met Ala Lys Thr Leu Ala Asn Lys His Gly Tyr Gln 
        355                 360                 365             


Val Asp Gly Asn Gln Glu Leu Ile Ala Leu Gly Leu Cys Asn Ser Ile 
    370                 375                 380                 


Gly Ser Leu Phe Gln Thr Phe Ser Ile Ser Cys Ser Leu Ser Arg Ser 
385                 390                 395                 400 


Leu Val Gln Glu Gly Thr Gly Gly Lys Thr Gln Leu Ala Gly Cys Leu 
                405                 410                 415     


Ala Ser Leu Met Ile Leu Leu Val Ile Leu Ala Thr Gly Phe Leu Phe 
            420                 425                 430         


Glu Ser Leu Pro Gln Ala Val Leu Ser Ala Ile Val Ile Val Asn Leu 
        435                 440                 445             


Lys Gly Met Phe Met Gln Phe Ser Asp Leu Pro Phe Phe Trp Arg Thr 
    450                 455                 460                 


Ser Lys Ile Glu Leu Thr Ile Trp Leu Thr Thr Phe Val Ser Ser Leu 
465                 470                 475                 480 


Phe Leu Gly Leu Asp Tyr Gly Leu Ile Thr Ala Val Ile Ile Ala Leu 
                485                 490                 495     


Leu Thr Val Ile Tyr Arg Thr Gln Ser Pro Ser Tyr Lys Val Leu Gly 
            500                 505                 510         


Lys Leu Pro Glu Thr Asp Val Tyr Ile Asp Ile Asp Ala Tyr Glu Glu 
        515                 520                 525             


Val Lys Glu Ile Pro Gly Ile Lys Ile Phe Gln Ile Asn Ala Pro Ile 
    530                 535                 540                 


Tyr Tyr Ala Asn Ser Asp Leu Tyr Ser Asn Ala Leu Lys Arg Lys Thr 
545                 550                 555                 560 


Gly Val Asn Pro Ala Val Ile Met Gly Ala Arg Arg Lys Ala Met Arg 
                565                 570                 575     


Lys Tyr Ala Lys Glu Val Gly Asn Ala Asn Met Ala Asn Ala Thr Val 
            580                 585                 590         


Val Lys Ala Asp Ala Glu Val Asp Gly Glu Asp Ala Thr Lys Pro Glu 
        595                 600                 605             


Glu Glu Asp Gly Glu Val Lys Tyr Pro Pro Ile Val Ile Lys Ser Thr 
    610                 615                 620                 


Phe Pro Glu Glu Met Gln Arg Phe Met Pro Pro Gly Asp Asn Val His 
625                 630                 635                 640 


Thr Val Ile Leu Asp Phe Thr Gln Val Asn Phe Ile Asp Ser Val Gly 
                645                 650                 655     


Val Lys Thr Leu Ala Gly Ile Val Lys Glu Tyr Gly Asp Val Gly Ile 
            660                 665                 670         


Tyr Val Tyr Leu Ala Gly Cys Ser Ala Phe Ile Gln Arg 
        675                 680                 685 


<210>  2093
<211>  1965
<212>  DNA
<213>  Homosapiens

<400>  2093
aggcagcggc tgtggagcgc ggcggggcgg ctccgcccag ggcagcccgg gctgggccaa     60

ggagcgagct ctcccttctc ctgctctcag cctcagtgat caaggcttca gtgaactgca    120

ctggagctcc cagcggggga tcttgtcccc tgtcccgact tttgtgctgc acattggatc    180

tggtgacact caggaaatgc ttgtctccgg ctgttaagga ataatttcag agtactatgg    240

atcatgctga agaaaatgaa atccttgcag caacccagag gtactatgtg gaaaggccta    300

tctttagtca tccggtcctc caggaaagac tacacacaaa ggacaaggtt cctgattcca    360

ttgcggataa gctgaaacag gcattcacat gtactcctaa aaaaataaga aatatcattt    420

atatgttcct acccataact aaatggctgc cagcatacaa attcaaggaa tatgtgttgg    480

gtgacttggt ctcaggcata agcacagggg tgcttcagct tcctcaaggc ttagcctttg    540

caatgctggc agctgtgcct ccaatatttg gcctgtactc ttcattttac cctgttatca    600

tgtattgttt tcttggaacc tccagacaca tatccatagg tccttttgct gttattagcc    660

tgatgattgg tggtgtagct gttcgattag taccagatga tatagtcatt ccaggaggag    720

taaatgcaac caatggcaca gaggccagag atgccttgag agtgaaagtc gccatgtctg    780

tgaccttact ttcaggaatc attcagtttt gcctaggtgt ctgtaggttt ggatttgtgg    840

ccatatatct cacagagcct ctggtccgtg ggtttaccac cgcagcagct gtgcatgtct    900

tcacctccat gttaaaatat ctgtttggag ttaaaacaaa gcggtacagt ggaatctttt    960

ccgtggtgta tagtacagtt gctgtgttgc agaatgttaa aaacctcaac gtgtgttccc   1020

taggcgtcgg gctgatggtt tttggtttgc tgttgggtgg caaggagttt aatgagagat   1080

ttaaagagaa attgccggcg cctattcctt tagagttctt tgcggtcgta atgggaactg   1140

gcatttcagc tgggtttaac ttgaaagaat catacaatgt ggatgtcgtt ggaacacttc   1200

ctctagggct gctacctcca gccaatccgg acaccagcct cttccacctt gtgtacgtag   1260

atgccattgc catagccatc gttggatttt cagtgaccat ctccatggcc aagaccttag   1320

caaataaaca tggctaccag gttgacggca atcaggagct cattgccctg ggactgtgca   1380

attccattgg ctcactcttc cagacctttt caatttcatg ctccttgtct cgaagccttg   1440

ttcaggaggg aaccggtggg aagacacagc ttgcaggttg tttggcctca ttaatgattc   1500

tgctggtcat attagcaact ggattcctct ttgaatcatt gccccaggct gtgctgtcgg   1560

ccattgtgat tgtcaacctg aagggaatgt ttatgcagtt ctcagatctc ccctttttct   1620

ggagaaccag caaaatagag ctgaccatct ggcttaccac ttttgtgtcc tccttgttcc   1680

tgggattgga ctatggtttg atcactgctg tgatcattgc tctgctgact gtgatttaca   1740

gaacacagag ctttcataca gagatgacca gaagatggag accgtagggg aaatgccgtg   1800

taatccaagc agttcaggct ttggggccag gtggacaggg tttgaatgcc agctctggaa   1860

tctgttagtg gggtgacctc agccaagtca cttaacactt ctgaactttg ttttctcttt   1920

tgtgaaataa agaaaaaatg aatctacaaa aaaaaaaaaa aaaaa                   1965


<210>  2094
<211>  516
<212>  PRT
<213>  Homosapiens

<400>  2094

Met Asp His Ala Glu Glu Asn Glu Ile Leu Ala Ala Thr Gln Arg Tyr 
1               5                   10                  15      


Tyr Val Glu Arg Pro Ile Phe Ser His Pro Val Leu Gln Glu Arg Leu 
            20                  25                  30          


His Thr Lys Asp Lys Val Pro Asp Ser Ile Ala Asp Lys Leu Lys Gln 
        35                  40                  45              


Ala Phe Thr Cys Thr Pro Lys Lys Ile Arg Asn Ile Ile Tyr Met Phe 
    50                  55                  60                  


Leu Pro Ile Thr Lys Trp Leu Pro Ala Tyr Lys Phe Lys Glu Tyr Val 
65                  70                  75                  80  


Leu Gly Asp Leu Val Ser Gly Ile Ser Thr Gly Val Leu Gln Leu Pro 
                85                  90                  95      


Gln Gly Leu Ala Phe Ala Met Leu Ala Ala Val Pro Pro Ile Phe Gly 
            100                 105                 110         


Leu Tyr Ser Ser Phe Tyr Pro Val Ile Met Tyr Cys Phe Leu Gly Thr 
        115                 120                 125             


Ser Arg His Ile Ser Ile Gly Pro Phe Ala Val Ile Ser Leu Met Ile 
    130                 135                 140                 


Gly Gly Val Ala Val Arg Leu Val Pro Asp Asp Ile Val Ile Pro Gly 
145                 150                 155                 160 


Gly Val Asn Ala Thr Asn Gly Thr Glu Ala Arg Asp Ala Leu Arg Val 
                165                 170                 175     


Lys Val Ala Met Ser Val Thr Leu Leu Ser Gly Ile Ile Gln Phe Cys 
            180                 185                 190         


Leu Gly Val Cys Arg Phe Gly Phe Val Ala Ile Tyr Leu Thr Glu Pro 
        195                 200                 205             


Leu Val Arg Gly Phe Thr Thr Ala Ala Ala Val His Val Phe Thr Ser 
    210                 215                 220                 


Met Leu Lys Tyr Leu Phe Gly Val Lys Thr Lys Arg Tyr Ser Gly Ile 
225                 230                 235                 240 


Phe Ser Val Val Tyr Ser Thr Val Ala Val Leu Gln Asn Val Lys Asn 
                245                 250                 255     


Leu Asn Val Cys Ser Leu Gly Val Gly Leu Met Val Phe Gly Leu Leu 
            260                 265                 270         


Leu Gly Gly Lys Glu Phe Asn Glu Arg Phe Lys Glu Lys Leu Pro Ala 
        275                 280                 285             


Pro Ile Pro Leu Glu Phe Phe Ala Val Val Met Gly Thr Gly Ile Ser 
    290                 295                 300                 


Ala Gly Phe Asn Leu Lys Glu Ser Tyr Asn Val Asp Val Val Gly Thr 
305                 310                 315                 320 


Leu Pro Leu Gly Leu Leu Pro Pro Ala Asn Pro Asp Thr Ser Leu Phe 
                325                 330                 335     


His Leu Val Tyr Val Asp Ala Ile Ala Ile Ala Ile Val Gly Phe Ser 
            340                 345                 350         


Val Thr Ile Ser Met Ala Lys Thr Leu Ala Asn Lys His Gly Tyr Gln 
        355                 360                 365             


Val Asp Gly Asn Gln Glu Leu Ile Ala Leu Gly Leu Cys Asn Ser Ile 
    370                 375                 380                 


Gly Ser Leu Phe Gln Thr Phe Ser Ile Ser Cys Ser Leu Ser Arg Ser 
385                 390                 395                 400 


Leu Val Gln Glu Gly Thr Gly Gly Lys Thr Gln Leu Ala Gly Cys Leu 
                405                 410                 415     


Ala Ser Leu Met Ile Leu Leu Val Ile Leu Ala Thr Gly Phe Leu Phe 
            420                 425                 430         


Glu Ser Leu Pro Gln Ala Val Leu Ser Ala Ile Val Ile Val Asn Leu 
        435                 440                 445             


Lys Gly Met Phe Met Gln Phe Ser Asp Leu Pro Phe Phe Trp Arg Thr 
    450                 455                 460                 


Ser Lys Ile Glu Leu Thr Ile Trp Leu Thr Thr Phe Val Ser Ser Leu 
465                 470                 475                 480 


Phe Leu Gly Leu Asp Tyr Gly Leu Ile Thr Ala Val Ile Ile Ala Leu 
                485                 490                 495     


Leu Thr Val Ile Tyr Arg Thr Gln Ser Phe His Thr Glu Met Thr Arg 
            500                 505                 510         


Arg Trp Arg Pro 
        515     


<210>  2095
<211>  1422
<212>  DNA
<213>  Homosapiens

<400>  2095
aggcagcggc tgtggagcgc ggcggggcgg ctccgcccag ggcagcccgg gctgggccaa     60

ggagcgagct ctcccttctc ctgctctcag cctcagtgat caaggcttca gtgaactgca    120

ctggagctcc cagcggggga tcttgtcccc tgtcccgact tttgtgctgc acattggatc    180

tggtgacact caggaaatgc ttgtctccgg ctgttaagga ataatttcag agtactatgg    240

atcatgctga agaaaatgaa atccttgcag caacccagag gtactatgtg gaaaggccta    300

tctttagtca tccggtcctc caggaaagac tacacacaaa ggacaaggtt cctgattcca    360

ttgcggataa gctgaaacag gcattcacat gtactcctaa aaaaataaga aatatcattt    420

atatgttcct acccataact aaatggctgc cagcatacaa attcaaggaa tatgtgttgg    480

gtgacttggt ctcaggcata agcacagggg tgcttcagct tcctcaaggc ttagcctttg    540

caatgctggc agctgtgcct ccaatatttg gcctgtactc ttcattttac cctgttatca    600

tgtattgttt tcttggaacc tccagacaca tatccatagg tccttttgct gttattagcc    660

tgatgattgg tggtgtagct gttcgattag taccagatga tatagtcatt ccaggaggag    720

taaatgcaac caatggcaca gaggccagag atgccttgag agtgaaagtc gccatgtctg    780

tgaccttact ttcaggaatc attcagtttt gcctaggtgt ctgtaggttt ggatttgtgg    840

ccatatatct cacagagcct ctggtccgtg ggtttaccac cgcagcagct gtgcatgtct    900

tcacctccat gttaaaatat ctgtttggag ttaaaacaaa gcggtacagt ggaatctttt    960

ccgtggtgta tagtacagtt gctgtgttgc agaatgttaa aaacctcaac gtgtgttccc   1020

taggcgtcgg gctgatggtt tttggtttgc tgttgggtgg caaggagttt aatgagagat   1080

ttaaagagaa attgccggcg cctattcctt tagagttctt tgcggtcgta atgggaactg   1140

gcatttcagc tgggtttaac ttgaaagaat catacaatgt ggatgtcgtt ggaacacttc   1200

ctctaggctt tcatacagag atgaccagaa gatggagacc gtaggggaaa tgccgtgtaa   1260

tccaagcagt tcaggctttg gggccaggtg gacagggttt gaatgccagc tctggaatct   1320

gttagtgggg tgacctcagc caagtcactt aacacttctg aactttgttt tctcttttgt   1380

gaaataaaga aaaaatgaat ctacaaaaaa aaaaaaaaaa aa                      1422


<210>  2096
<211>  335
<212>  PRT
<213>  Homosapiens

<400>  2096

Met Asp His Ala Glu Glu Asn Glu Ile Leu Ala Ala Thr Gln Arg Tyr 
1               5                   10                  15      


Tyr Val Glu Arg Pro Ile Phe Ser His Pro Val Leu Gln Glu Arg Leu 
            20                  25                  30          


His Thr Lys Asp Lys Val Pro Asp Ser Ile Ala Asp Lys Leu Lys Gln 
        35                  40                  45              


Ala Phe Thr Cys Thr Pro Lys Lys Ile Arg Asn Ile Ile Tyr Met Phe 
    50                  55                  60                  


Leu Pro Ile Thr Lys Trp Leu Pro Ala Tyr Lys Phe Lys Glu Tyr Val 
65                  70                  75                  80  


Leu Gly Asp Leu Val Ser Gly Ile Ser Thr Gly Val Leu Gln Leu Pro 
                85                  90                  95      


Gln Gly Leu Ala Phe Ala Met Leu Ala Ala Val Pro Pro Ile Phe Gly 
            100                 105                 110         


Leu Tyr Ser Ser Phe Tyr Pro Val Ile Met Tyr Cys Phe Leu Gly Thr 
        115                 120                 125             


Ser Arg His Ile Ser Ile Gly Pro Phe Ala Val Ile Ser Leu Met Ile 
    130                 135                 140                 


Gly Gly Val Ala Val Arg Leu Val Pro Asp Asp Ile Val Ile Pro Gly 
145                 150                 155                 160 


Gly Val Asn Ala Thr Asn Gly Thr Glu Ala Arg Asp Ala Leu Arg Val 
                165                 170                 175     


Lys Val Ala Met Ser Val Thr Leu Leu Ser Gly Ile Ile Gln Phe Cys 
            180                 185                 190         


Leu Gly Val Cys Arg Phe Gly Phe Val Ala Ile Tyr Leu Thr Glu Pro 
        195                 200                 205             


Leu Val Arg Gly Phe Thr Thr Ala Ala Ala Val His Val Phe Thr Ser 
    210                 215                 220                 


Met Leu Lys Tyr Leu Phe Gly Val Lys Thr Lys Arg Tyr Ser Gly Ile 
225                 230                 235                 240 


Phe Ser Val Val Tyr Ser Thr Val Ala Val Leu Gln Asn Val Lys Asn 
                245                 250                 255     


Leu Asn Val Cys Ser Leu Gly Val Gly Leu Met Val Phe Gly Leu Leu 
            260                 265                 270         


Leu Gly Gly Lys Glu Phe Asn Glu Arg Phe Lys Glu Lys Leu Pro Ala 
        275                 280                 285             


Pro Ile Pro Leu Glu Phe Phe Ala Val Val Met Gly Thr Gly Ile Ser 
    290                 295                 300                 


Ala Gly Phe Asn Leu Lys Glu Ser Tyr Asn Val Asp Val Val Gly Thr 
305                 310                 315                 320 


Leu Pro Leu Gly Phe His Thr Glu Met Thr Arg Arg Trp Arg Pro 
                325                 330                 335 


<210>  2097
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  2097
tcggcggggg cccgctccca ggcccgctcc cgagcccgtt ccgctcccgt ccgccttctt     60

ctcgccttct ctccgcgtgg ctcctccgtc ccggcgtctc caaaactgaa tgagcgagcg    120

gcgcgtaggg cgcgcggcgg cggcggcggc ggcggcggca tggagcgcag tggctgggcc    180

cggcagactt tcctcctagc gctgttgctg ggggcgacgc tgagggcgcg cgcggcggct    240

ggctattacc cccgcttttc gcccttcttt ttcctgtgca cccaccacgg ggagctggaa    300

ggggatgggg agcagggcga ggtgctcatt tccctgcata ttgcgggcaa ccccacctac    360

tacgttccgg gacaagaata ccatgtgaca atttcaacaa gcaccttttt tgacggcttg    420

ctggtgacag gactatacac atctacaagt gttcaggcat cacagagcat tggaggttcc    480

agtgctttcg gatttgggat catgtctgac caccagtttg gtaaccagtt tatgtgcagt    540

gtggtagcct ctcacgtgag tcacctgccc acaaccaacc tcagtttcat ctggattgct    600

ccacctgcgg gcacaggctg tgtgaatttc atggctacag caacacaccg gggccaggtt    660

attttcaaag atgctttagc ccagcagttg tgtgaacaag gagctccaac agatgtcact    720

gtgcacccac atctagctga aatacatagt gacagcatta tcctgagaga tgactttgac    780

tcctaccacc aactgcaatt aaatccaaat atatgggttg aatgtaacaa ctgtgagact    840

ggagaacagt gtggcgcgat tatgcatggc aatgccgtca ccttctgtga accatatggc    900

ccacgagaac tgattaccac aggccttaat acaacaacag cttctgtcct ccaattttcc    960

attgggtcag gttcatgtcg ctttagttat tcagacccca gcatcatcgt gttatatgcc   1020

aagaataact ctgcggactg gattcagcta gagaaaatta gagccccttc caatgtcagc   1080

acaatcatcc atatcctcta ccttcctgag gacgccaaag gggagaatgt ccaatttcag   1140

tggaagcagg aaaatcttcg tgtaggtgaa gtgtatgaag cctgctgggc cttagataac   1200

atcttgatca tcaattcagc tcacagacaa gtcgttttag aagatagtct cgacccagtg   1260

gacacaggca actggctttt cttcccagga gctacagtta agcatagctg tcagtcagat   1320

gggaactcca tttatttcca tggaaatgaa ggcagcgagt tcaattttgc caccaccagg   1380

gatgtagatc tttccacaga agatattcaa gagcaatggt cagaagaatt tgagagccag   1440

cctacaggat gggatgtctt gggagctgtc attggtacag aatgtggaac gatagaatca   1500

ggcttatcaa tggtcttcct caaagatgga gagaggaaat tatgcactcc atccatggac   1560

actaccggtt atgggaacct gaggttttac tttgtgatgg gaggaatttg tgaccctgga   1620

aattctcatg aaaatgacat aatcctgtat gcaaaaattg aaggaagaaa agagcatata   1680

acactggata ccctttccta ttcctcatat aaggttccgt ctttggtttc tgtggtcatc   1740

aatcctgaac ttcagactcc tgctaccaaa ttttgtctca ggcaaaagaa ccatcaagga   1800

cataatagga atgtctgggc tgtagacttt ttccatgtct tgcctgttct cccttctaca   1860

atgtctcaca tgatacagtt ttccatcaat ctgggatgtg gaacgcatca gcctggtaac   1920

agtgtcagct tggaattttc taccaaccat gggcgctcct ggtccctcct tcacactgaa   1980

tgcttacctg agatctgtgc tggaccccac ctcccccaca gcactgtcta ctcctctgaa   2040

aactacagtg ggtggaaccg aataacaatt ccccttccta acgcagcact aacccggaac   2100

accaggattc gctggagaca aacaggacca atccttggaa acatgtgggc aattgataat   2160

gtttatattg gcccgtcatg tctcaaattc tgttctggca gaggacagtg cactagacat   2220

ggttgcaagt gtgaccctgg attttctggc ccagcttgtg agatggcatc ccagacattc   2280

ccaatgttta tttctgaaag ctttggcagt tccaggctct cctcttacca taacttttac   2340

tctatccgtg gtgctgaagt cagctttggt tgtggtgtct tggccagtgg taaggccctg   2400

gttttcaaca aagatgggcg gcgtcagcta attacatctt tccttgacag ctcacaatcc   2460

aggtttctcc agttcacact gagactgggg agcaaatctg ttctgagcac gtgcagagcc   2520

cctgatcagc ctggtgaagg agttttgttg cattattctt atgataatgg gataacttgg   2580

aaactcctgg agcattattc atatctcagc tatcatgagc ccagaataat ctccgtagaa   2640

ctaccaggtg atgcaaagca gtttggaatt cagttcagat ggtggcaacc gtatcattct   2700

tcccagagag aagatgtatg ggctattgat gagattatca tgacatctgt gcttttcaac   2760

agcattagtc ttgactttac caatcttgtg gaggtcactc agtctctggg attctacctt   2820

ggaaatgttc agccatactg tggccacgac tggacccttt gttttacagg agattctaaa   2880

cttgcctcaa gtatgcgcta tgtggaaaca caatcaatgc agataggagc atcctatatg   2940

attcagttca gtttggtgat gggatgtggc cagaaataca ccccacacat ggacaaccag   3000

gtgaagctgg agtactcaac caaccacggc cttacctggc acctcgtcca agaagaatgc   3060

cttccaagta tgccaagttg tcaggaattt acatcagcaa gtatttacca tgccagtgag   3120

tttacacagt ggaggagagt catagtgctt cttccccaga aaacttggtc cagtgctacc   3180

cgtttccgct ggagccagag ctattacaca gctcaagacg agtgggcttt ggacagcatt   3240

tacattgggc agcagtgccc caacatgtgc agtgggcatg gctcatgcga tcatggcata   3300

tgcaggtgtg accaggggta ccaaggcact gaatgccacc cagaagctgc ccttccgtcc   3360

acaattatgt cagattttga gaaccagaat ggctgggagt ctgactggca agaagttatt   3420

gggggagaaa ttgtaaaacc agaacaaggg tgtggtgtca tctcttctgg atcatctctg   3480

tacttcagca aggctgggaa aagacagctg gtgagttggg acctggatac ttcttgggtg   3540

gactttgtcc agttctacat ccagataggc ggagagagtg cttcatgcaa caagcctgac   3600

agcagagagg agggcgtcct ccttcagtac agcaacaatg ggggcatcca gtggcacctg   3660

ctagcagaga tgtacttttc agacttcagc aaacccagat ttgtctatct ggagcttcca   3720

gctgctgcca agaccccttg caccaggttc cgctggtggc agcccgtgtt ctcaggggag   3780

gactatgacc agtgggcagt cgatgacatc atcattctgt ccgagaagca gaagcagatc   3840

atcccagtta tcaatccaac tttacctcag aacttttatg agaagccagc ttttgattac   3900

cctatgaatc agatgagtgt gtggttgatg ttggctaatg aaggaatggt taaaaatgaa   3960

accttctgtg ctgccacacc atcagcaatg atatttggaa aatcagatgg agatcgattt   4020

gcagtaactc gagatttgac cctgaaacct ggatatgtgc tacagttcaa gctaaacata   4080

ggttgtgcca atcaattcag cagtactgct ccagttcttc ttcagtactc tcatgatgct   4140

ggtatgtcct ggtttctggt gaaagaaggc tgttacccgg cttctgcagg caaaggatgc   4200

gaaggaaact ccagagaact aagtgagccc accatgtatc acacagggga ctttgaagaa   4260

tggacaagaa tcaccattgt tattccaagg tctcttgcat ccagcaagac cagattccga   4320

tggatccagg agagcagctc acagaaaaac gtgcctccat ttggtttaga tggagtgtac   4380

atatccgagc cttgtcccag ttactgcagt ggccatgggg actgcatttc aggagtgtgt   4440

ttctgtgacc tgggatatac tgctgcacaa ggaacctgtg tgtcaaatgt ccccaatcac   4500

aatgagatgt tcgataggtt tgaggggaag ctcagccctc tgtggtacaa gataacaggt   4560

gcccaggttg gaactggctg tggaacactt aacgatggca aatctctcta cttcaatggc   4620

cctgggaaaa gggaagcccg gacggtccct ctggacacca ggaatatcag acttgttcaa   4680

ttttatatac aaattggaag caaaacttca ggcattacct gcatcaaacc aagaactaga   4740

aatgaagggc ttattgttca gtattcaaat gacaatggga tactctggca tttgcttcga   4800

gagttggact tcatgtcctt cctggaacca cagatcattt ccattgacct gccacaggac   4860

gcgaagacac ctgcaacggc atttcgatgg tggcaaccgc aacatgggaa gcattcagcc   4920

cagtgggctt tggatgatgt tcttatagga atgaatgaca gctctcaaac tggatttcaa   4980

gacaaatttg atggctctat agatttgcaa gccaactggt atcgaatcca aggaggtcaa   5040

gttgatattg actgtctctc tatggatact gctctgatat tcactgaaaa cataggaaaa   5100

cctcgttatg ctgagacctg ggattttcat gtgtcagcat ctaccttttt gcagtttgaa   5160

atgagcatgg gctgtagcaa gcccttcagc aactcccaca gtgtacagct ccagtattct   5220

ctgaacaatg gcaaggactg gcatcttgtc accgaagagt gtgttcctcc aaccattggc   5280

tgtctgcatt acacggaaag ttcaatttac acctcggaaa gattccagaa ttggaagcgg   5340

atcactgtct accttccact ctccaccatt tctcccagga cccggttcag atggattcag   5400

gccaactaca ctgtgggggc tgattcctgg gcgattgata atgttgtact ggcctcaggg   5460

tgcccttgga tgtgctcagg acgagggatt tgtgatgctg gacgctgtgt gtgtgaccgg   5520

ggctttggtg gaccctattg tgttcctgtt gttcctctgc cctcgattct taaagacgat   5580

ttcaatggga atttacatcc tgacctttgg cctgaagtgt atggtgcaga gagggggaat   5640

ctgaatggtg aaaccatcaa atctggaaca tctctaattt ttaaagggga aggactaagg   5700

atgcttattt caagagatct agattgtaca aatacaatgt atgtccagtt ttcacttaga   5760

tttatagcaa aaagtacccc agagagatct cactctattc tgttacaatt ctccatcagt   5820

ggaggaatca cttggcacct gatggatgaa ttttactttc ctcaaacaac gaatatactt   5880

ttcatcaatg ttcccttgcc atacactgcc caaaccaatg ctacaagatt cagactctgg   5940

caaccttata ataacggtaa gaaagaagaa atctggattg ttgatgactt cattatcgat   6000

ggaaataatg taaacaaccc tgtgatgctc ttggatacat ttgattttgg gcccagagaa   6060

gacaattggt ttttctatcc tggtggtaac atcggtcttt attgtccata ttcttcaaag   6120

ggggcacctg aagaagattc agctatggtg tttgtttcaa atgaagttgg tgagcattcc   6180

attaccaccc gtgacctaaa tgtgaatgag aacaccatca tacaatttga gatcaacgtt   6240

ggctgttcga ctgatagctc atccgcggat ccagtgagac tggaattttc aagggacttc   6300

ggggcgacct ggcaccttct gctgcccctc tgctaccaca gcagcagcca cgtcagctct   6360

ttatgctcca ccgagcacca ccccagcagc acctactacg caggaaccat gcagggctgg   6420

aggagggagg tcgtgcactt tgggaagctg cacctttgtg gatctgtccg tttcagatgg   6480

taccagggat tttaccctgc cggctctcag ccagtgacat gggccattga taatgtctac   6540

atcggtcccc agtgtgagga gatgtgtaat ggacagggga gctgtatcaa tggaaccaaa   6600

tgtatatgtg accctggcta ctcaggtcca acctgtaaaa taagcaccaa aaatcctgat   6660

tttctcaaag atgatttcga aggtcagcta gaatctgata gattcttatt aatgagtggt   6720

gggaaaccat ctcgaaagtg tggaatcctt tctagtggaa acaacctctt tttcaatgaa   6780

gatggcttgc gcatgttgat gacacgagac ctggatttat cacatgctag atttgtgcag   6840

ttcttcatga gactgggatg tggtaaaggc gttcctgacc ccaggagtca acccgtgctc   6900

ctacagtatt ctctcaacgg tggcctctcg tggagtcttc ttcaggagtt ccttttcagc   6960

aattccagca atgtgggcag gtacattgcc ctggagatac ccttgaaagc ccgttctggt   7020

tctactcgcc ttcgctggtg gcaaccgtct gagaatgggc acttctacag cccctgggtt   7080

atcgatcaga ttcttattgg aggaaatatt tctggtaata cggtcttgga agatgatttc   7140

acaacccttg atagtaggaa atggctgctt cacccaggag gcaccaagat gcccgtgtgt   7200

ggctctactg gtgatgccct ggtcttcatt gaaaaggcca gcacccgtta cgtggtcagc   7260

acagacgttg ccgtgaatga ggattccttc ctacagatag acttcgctgc ctcctgctca   7320

gtcacagact cttgttatgc gattgaattg gaatactcag tagatcttgg attgtcatgg   7380

cacccattgg taagggactg tctgcctacc aatgtggaat gcagtcgcta tcatctgcaa   7440

cggatcctgg tgtcagacac tttcaacaag tggactagaa tcactctgcc tctccctcct   7500

tataccaggt cccaagccac tcgtttccgt tggcatcaac cagctccttt tgacaagcag   7560

cagacatggg caatagataa tgtctatatc ggggatggct gcatagacat gtgcagtggc   7620

catgggagat gcatccaggg aaactgcgtc tgtgatgaac agtggggtgg cctgtactgt   7680

gatgaccccg agacctctct tccaacccaa ctcaaagaca acttcaatcg agctccatcc   7740

agtcagaact ggctgactgt gaacggaggg aaattgagta cagtgtgtgg agccgtggcg   7800

tcgggaatgg ctctccattt cagtgggggt tgtagtcgat tattagtcac tgtggatcta   7860

aacctcacta atgctgagtt catccaattt tacttcatgt atgggtgcct gattacacca   7920

aacaaccgta accaaggtgt tctcttggaa tattctgtca atggaggcat tacctggaac   7980

ctgctcatgg agattttcta tgaccagtac agtaagcccg ggtttgtgaa tatccttctc   8040

cctcctgatg ctaaagagat tgccactcgc ttccgctggt ggcagccaag acatgacggc   8100

ctggatcaga acgactgggc cattgacaat gtcctcatct caggctctgc tgaccaaagg   8160

accgttatgc tggacacctt cagcagcgcc cc                                 8192


<210>  2098
<211>  3460
<212>  PRT
<213>  Homosapiens

<400>  2098

Met Glu Arg Ser Gly Trp Ala Arg Gln Thr Phe Leu Leu Ala Leu Leu 
1               5                   10                  15      


Leu Gly Ala Thr Leu Arg Ala Arg Ala Ala Ala Gly Tyr Tyr Pro Arg 
            20                  25                  30          


Phe Ser Pro Phe Phe Phe Leu Cys Thr His His Gly Glu Leu Glu Gly 
        35                  40                  45              


Asp Gly Glu Gln Gly Glu Val Leu Ile Ser Leu His Ile Ala Gly Asn 
    50                  55                  60                  


Pro Thr Tyr Tyr Val Pro Gly Gln Glu Tyr His Val Thr Ile Ser Thr 
65                  70                  75                  80  


Ser Thr Phe Phe Asp Gly Leu Leu Val Thr Gly Leu Tyr Thr Ser Thr 
                85                  90                  95      


Ser Val Gln Ala Ser Gln Ser Ile Gly Gly Ser Ser Ala Phe Gly Phe 
            100                 105                 110         


Gly Ile Met Ser Asp His Gln Phe Gly Asn Gln Phe Met Cys Ser Val 
        115                 120                 125             


Val Ala Ser His Val Ser His Leu Pro Thr Thr Asn Leu Ser Phe Ile 
    130                 135                 140                 


Trp Ile Ala Pro Pro Ala Gly Thr Gly Cys Val Asn Phe Met Ala Thr 
145                 150                 155                 160 


Ala Thr His Arg Gly Gln Val Ile Phe Lys Asp Ala Leu Ala Gln Gln 
                165                 170                 175     


Leu Cys Glu Gln Gly Ala Pro Thr Asp Val Thr Val His Pro His Leu 
            180                 185                 190         


Ala Glu Ile His Ser Asp Ser Ile Ile Leu Arg Asp Asp Phe Asp Ser 
        195                 200                 205             


Tyr His Gln Leu Gln Leu Asn Pro Asn Ile Trp Val Glu Cys Asn Asn 
    210                 215                 220                 


Cys Glu Thr Gly Glu Gln Cys Gly Ala Ile Met His Gly Asn Ala Val 
225                 230                 235                 240 


Thr Phe Cys Glu Pro Tyr Gly Pro Arg Glu Leu Ile Thr Thr Gly Leu 
                245                 250                 255     


Asn Thr Thr Thr Ala Ser Val Leu Gln Phe Ser Ile Gly Ser Gly Ser 
            260                 265                 270         


Cys Arg Phe Ser Tyr Ser Asp Pro Ser Ile Ile Val Leu Tyr Ala Lys 
        275                 280                 285             


Asn Asn Ser Ala Asp Trp Ile Gln Leu Glu Lys Ile Arg Ala Pro Ser 
    290                 295                 300                 


Asn Val Ser Thr Ile Ile His Ile Leu Tyr Leu Pro Glu Asp Ala Lys 
305                 310                 315                 320 


Gly Glu Asn Val Gln Phe Gln Trp Lys Gln Glu Asn Leu Arg Val Gly 
                325                 330                 335     


Glu Val Tyr Glu Ala Cys Trp Ala Leu Asp Asn Ile Leu Ile Ile Asn 
            340                 345                 350         


Ser Ala His Arg Gln Val Val Leu Glu Asp Ser Leu Asp Pro Val Asp 
        355                 360                 365             


Thr Gly Asn Trp Leu Phe Phe Pro Gly Ala Thr Val Lys His Ser Cys 
    370                 375                 380                 


Gln Ser Asp Gly Asn Ser Ile Tyr Phe His Gly Asn Glu Gly Ser Glu 
385                 390                 395                 400 


Phe Asn Phe Ala Thr Thr Arg Asp Val Asp Leu Ser Thr Glu Asp Ile 
                405                 410                 415     


Gln Glu Gln Trp Ser Glu Glu Phe Glu Ser Gln Pro Thr Gly Trp Asp 
            420                 425                 430         


Val Leu Gly Ala Val Ile Gly Thr Glu Cys Gly Thr Ile Glu Ser Gly 
        435                 440                 445             


Leu Ser Met Val Phe Leu Lys Asp Gly Glu Arg Lys Leu Cys Thr Pro 
    450                 455                 460                 


Ser Met Asp Thr Thr Gly Tyr Gly Asn Leu Arg Phe Tyr Phe Val Met 
465                 470                 475                 480 


Gly Gly Ile Cys Asp Pro Gly Asn Ser His Glu Asn Asp Ile Ile Leu 
                485                 490                 495     


Tyr Ala Lys Ile Glu Gly Arg Lys Glu His Ile Thr Leu Asp Thr Leu 
            500                 505                 510         


Ser Tyr Ser Ser Tyr Lys Val Pro Ser Leu Val Ser Val Val Ile Asn 
        515                 520                 525             


Pro Glu Leu Gln Thr Pro Ala Thr Lys Phe Cys Leu Arg Gln Lys Asn 
    530                 535                 540                 


His Gln Gly His Asn Arg Asn Val Trp Ala Val Asp Phe Phe His Val 
545                 550                 555                 560 


Leu Pro Val Leu Pro Ser Thr Met Ser His Met Ile Gln Phe Ser Ile 
                565                 570                 575     


Asn Leu Gly Cys Gly Thr His Gln Pro Gly Asn Ser Val Ser Leu Glu 
            580                 585                 590         


Phe Ser Thr Asn His Gly Arg Ser Trp Ser Leu Leu His Thr Glu Cys 
        595                 600                 605             


Leu Pro Glu Ile Cys Ala Gly Pro His Leu Pro His Ser Thr Val Tyr 
    610                 615                 620                 


Ser Ser Glu Asn Tyr Ser Gly Trp Asn Arg Ile Thr Ile Pro Leu Pro 
625                 630                 635                 640 


Asn Ala Ala Leu Thr Arg Asn Thr Arg Ile Arg Trp Arg Gln Thr Gly 
                645                 650                 655     


Pro Ile Leu Gly Asn Met Trp Ala Ile Asp Asn Val Tyr Ile Gly Pro 
            660                 665                 670         


Ser Cys Leu Lys Phe Cys Ser Gly Arg Gly Gln Cys Thr Arg His Gly 
        675                 680                 685             


Cys Lys Cys Asp Pro Gly Phe Ser Gly Pro Ala Cys Glu Met Ala Ser 
    690                 695                 700                 


Gln Thr Phe Pro Met Phe Ile Ser Glu Ser Phe Gly Ser Ser Arg Leu 
705                 710                 715                 720 


Ser Ser Tyr His Asn Phe Tyr Ser Ile Arg Gly Ala Glu Val Ser Phe 
                725                 730                 735     


Gly Cys Gly Val Leu Ala Ser Gly Lys Ala Leu Val Phe Asn Lys Asp 
            740                 745                 750         


Gly Arg Arg Gln Leu Ile Thr Ser Phe Leu Asp Ser Ser Gln Ser Arg 
        755                 760                 765             


Phe Leu Gln Phe Thr Leu Arg Leu Gly Ser Lys Ser Val Leu Ser Thr 
    770                 775                 780                 


Cys Arg Ala Pro Asp Gln Pro Gly Glu Gly Val Leu Leu His Tyr Ser 
785                 790                 795                 800 


Tyr Asp Asn Gly Ile Thr Trp Lys Leu Leu Glu His Tyr Ser Tyr Leu 
                805                 810                 815     


Ser Tyr His Glu Pro Arg Ile Ile Ser Val Glu Leu Pro Gly Asp Ala 
            820                 825                 830         


Lys Gln Phe Gly Ile Gln Phe Arg Trp Trp Gln Pro Tyr His Ser Ser 
        835                 840                 845             


Gln Arg Glu Asp Val Trp Ala Ile Asp Glu Ile Ile Met Thr Ser Val 
    850                 855                 860                 


Leu Phe Asn Ser Ile Ser Leu Asp Phe Thr Asn Leu Val Glu Val Thr 
865                 870                 875                 880 


Gln Ser Leu Gly Phe Tyr Leu Gly Asn Val Gln Pro Tyr Cys Gly His 
                885                 890                 895     


Asp Trp Thr Leu Cys Phe Thr Gly Asp Ser Lys Leu Ala Ser Ser Met 
            900                 905                 910         


Arg Tyr Val Glu Thr Gln Ser Met Gln Ile Gly Ala Ser Tyr Met Ile 
        915                 920                 925             


Gln Phe Ser Leu Val Met Gly Cys Gly Gln Lys Tyr Thr Pro His Met 
    930                 935                 940                 


Asp Asn Gln Val Lys Leu Glu Tyr Ser Thr Asn His Gly Leu Thr Trp 
945                 950                 955                 960 


His Leu Val Gln Glu Glu Cys Leu Pro Ser Met Pro Ser Cys Gln Glu 
                965                 970                 975     


Phe Thr Ser Ala Ser Ile Tyr His Ala Ser Glu Phe Thr Gln Trp Arg 
            980                 985                 990         


Arg Val Ile Val Leu Leu Pro Gln  Lys Thr Trp Ser Ser  Ala Thr Arg 
        995                 1000                 1005             


Phe Arg  Trp Ser Gln Ser Tyr  Tyr Thr Ala Gln Asp  Glu Trp Ala 
    1010                 1015                 1020             


Leu Asp  Ser Ile Tyr Ile Gly  Gln Gln Cys Pro Asn  Met Cys Ser 
    1025                 1030                 1035             


Gly His  Gly Ser Cys Asp His  Gly Ile Cys Arg Cys  Asp Gln Gly 
    1040                 1045                 1050             


Tyr Gln  Gly Thr Glu Cys His  Pro Glu Ala Ala Leu  Pro Ser Thr 
    1055                 1060                 1065             


Ile Met  Ser Asp Phe Glu Asn  Gln Asn Gly Trp Glu  Ser Asp Trp 
    1070                 1075                 1080             


Gln Glu  Val Ile Gly Gly Glu  Ile Val Lys Pro Glu  Gln Gly Cys 
    1085                 1090                 1095             


Gly Val  Ile Ser Ser Gly Ser  Ser Leu Tyr Phe Ser  Lys Ala Gly 
    1100                 1105                 1110             


Lys Arg  Gln Leu Val Ser Trp  Asp Leu Asp Thr Ser  Trp Val Asp 
    1115                 1120                 1125             


Phe Val  Gln Phe Tyr Ile Gln  Ile Gly Gly Glu Ser  Ala Ser Cys 
    1130                 1135                 1140             


Asn Lys  Pro Asp Ser Arg Glu  Glu Gly Val Leu Leu  Gln Tyr Ser 
    1145                 1150                 1155             


Asn Asn  Gly Gly Ile Gln Trp  His Leu Leu Ala Glu  Met Tyr Phe 
    1160                 1165                 1170             


Ser Asp  Phe Ser Lys Pro Arg  Phe Val Tyr Leu Glu  Leu Pro Ala 
    1175                 1180                 1185             


Ala Ala  Lys Thr Pro Cys Thr  Arg Phe Arg Trp Trp  Gln Pro Val 
    1190                 1195                 1200             


Phe Ser  Gly Glu Asp Tyr Asp  Gln Trp Ala Val Asp  Asp Ile Ile 
    1205                 1210                 1215             


Ile Leu  Ser Glu Lys Gln Lys  Gln Ile Ile Pro Val  Ile Asn Pro 
    1220                 1225                 1230             


Thr Leu  Pro Gln Asn Phe Tyr  Glu Lys Pro Ala Phe  Asp Tyr Pro 
    1235                 1240                 1245             


Met Asn  Gln Met Ser Val Trp  Leu Met Leu Ala Asn  Glu Gly Met 
    1250                 1255                 1260             


Val Lys  Asn Glu Thr Phe Cys  Ala Ala Thr Pro Ser  Ala Met Ile 
    1265                 1270                 1275             


Phe Gly  Lys Ser Asp Gly Asp  Arg Phe Ala Val Thr  Arg Asp Leu 
    1280                 1285                 1290             


Thr Leu  Lys Pro Gly Tyr Val  Leu Gln Phe Lys Leu  Asn Ile Gly 
    1295                 1300                 1305             


Cys Ala  Asn Gln Phe Ser Ser  Thr Ala Pro Val Leu  Leu Gln Tyr 
    1310                 1315                 1320             


Ser His  Asp Ala Gly Met Ser  Trp Phe Leu Val Lys  Glu Gly Cys 
    1325                 1330                 1335             


Tyr Pro  Ala Ser Ala Gly Lys  Gly Cys Glu Gly Asn  Ser Arg Glu 
    1340                 1345                 1350             


Leu Ser  Glu Pro Thr Met Tyr  His Thr Gly Asp Phe  Glu Glu Trp 
    1355                 1360                 1365             


Thr Arg  Ile Thr Ile Val Ile  Pro Arg Ser Leu Ala  Ser Ser Lys 
    1370                 1375                 1380             


Thr Arg  Phe Arg Trp Ile Gln  Glu Ser Ser Ser Gln  Lys Asn Val 
    1385                 1390                 1395             


Pro Pro  Phe Gly Leu Asp Gly  Val Tyr Ile Ser Glu  Pro Cys Pro 
    1400                 1405                 1410             


Ser Tyr  Cys Ser Gly His Gly  Asp Cys Ile Ser Gly  Val Cys Phe 
    1415                 1420                 1425             


Cys Asp  Leu Gly Tyr Thr Ala  Ala Gln Gly Thr Cys  Val Ser Asn 
    1430                 1435                 1440             


Val Pro  Asn His Asn Glu Met  Phe Asp Arg Phe Glu  Gly Lys Leu 
    1445                 1450                 1455             


Ser Pro  Leu Trp Tyr Lys Ile  Thr Gly Ala Gln Val  Gly Thr Gly 
    1460                 1465                 1470             


Cys Gly  Thr Leu Asn Asp Gly  Lys Ser Leu Tyr Phe  Asn Gly Pro 
    1475                 1480                 1485             


Gly Lys  Arg Glu Ala Arg Thr  Val Pro Leu Asp Thr  Arg Asn Ile 
    1490                 1495                 1500             


Arg Leu  Val Gln Phe Tyr Ile  Gln Ile Gly Ser Lys  Thr Ser Gly 
    1505                 1510                 1515             


Ile Thr  Cys Ile Lys Pro Arg  Thr Arg Asn Glu Gly  Leu Ile Val 
    1520                 1525                 1530             


Gln Tyr  Ser Asn Asp Asn Gly  Ile Leu Trp His Leu  Leu Arg Glu 
    1535                 1540                 1545             


Leu Asp  Phe Met Ser Phe Leu  Glu Pro Gln Ile Ile  Ser Ile Asp 
    1550                 1555                 1560             


Leu Pro  Gln Asp Ala Lys Thr  Pro Ala Thr Ala Phe  Arg Trp Trp 
    1565                 1570                 1575             


Gln Pro  Gln His Gly Lys His  Ser Ala Gln Trp Ala  Leu Asp Asp 
    1580                 1585                 1590             


Val Leu  Ile Gly Met Asn Asp  Ser Ser Gln Thr Gly  Phe Gln Asp 
    1595                 1600                 1605             


Lys Phe  Asp Gly Ser Ile Asp  Leu Gln Ala Asn Trp  Tyr Arg Ile 
    1610                 1615                 1620             


Gln Gly  Gly Gln Val Asp Ile  Asp Cys Leu Ser Met  Asp Thr Ala 
    1625                 1630                 1635             


Leu Ile  Phe Thr Glu Asn Ile  Gly Lys Pro Arg Tyr  Ala Glu Thr 
    1640                 1645                 1650             


Trp Asp  Phe His Val Ser Ala  Ser Thr Phe Leu Gln  Phe Glu Met 
    1655                 1660                 1665             


Ser Met  Gly Cys Ser Lys Pro  Phe Ser Asn Ser His  Ser Val Gln 
    1670                 1675                 1680             


Leu Gln  Tyr Ser Leu Asn Asn  Gly Lys Asp Trp His  Leu Val Thr 
    1685                 1690                 1695             


Glu Glu  Cys Val Pro Pro Thr  Ile Gly Cys Leu His  Tyr Thr Glu 
    1700                 1705                 1710             


Ser Ser  Ile Tyr Thr Ser Glu  Arg Phe Gln Asn Trp  Lys Arg Ile 
    1715                 1720                 1725             


Thr Val  Tyr Leu Pro Leu Ser  Thr Ile Ser Pro Arg  Thr Arg Phe 
    1730                 1735                 1740             


Arg Trp  Ile Gln Ala Asn Tyr  Thr Val Gly Ala Asp  Ser Trp Ala 
    1745                 1750                 1755             


Ile Asp  Asn Val Val Leu Ala  Ser Gly Cys Pro Trp  Met Cys Ser 
    1760                 1765                 1770             


Gly Arg  Gly Ile Cys Asp Ala  Gly Arg Cys Val Cys  Asp Arg Gly 
    1775                 1780                 1785             


Phe Gly  Gly Pro Tyr Cys Val  Pro Val Val Pro Leu  Pro Ser Ile 
    1790                 1795                 1800             


Leu Lys  Asp Asp Phe Asn Gly  Asn Leu His Pro Asp  Leu Trp Pro 
    1805                 1810                 1815             


Glu Val  Tyr Gly Ala Glu Arg  Gly Asn Leu Asn Gly  Glu Thr Ile 
    1820                 1825                 1830             


Lys Ser  Gly Thr Ser Leu Ile  Phe Lys Gly Glu Gly  Leu Arg Met 
    1835                 1840                 1845             


Leu Ile  Ser Arg Asp Leu Asp  Cys Thr Asn Thr Met  Tyr Val Gln 
    1850                 1855                 1860             


Phe Ser  Leu Arg Phe Ile Ala  Lys Ser Thr Pro Glu  Arg Ser His 
    1865                 1870                 1875             


Ser Ile  Leu Leu Gln Phe Ser  Ile Ser Gly Gly Ile  Thr Trp His 
    1880                 1885                 1890             


Leu Met  Asp Glu Phe Tyr Phe  Pro Gln Thr Thr Asn  Ile Leu Phe 
    1895                 1900                 1905             


Ile Asn  Val Pro Leu Pro Tyr  Thr Ala Gln Thr Asn  Ala Thr Arg 
    1910                 1915                 1920             


Phe Arg  Leu Trp Gln Pro Tyr  Asn Asn Gly Lys Lys  Glu Glu Ile 
    1925                 1930                 1935             


Trp Ile  Val Asp Asp Phe Ile  Ile Asp Gly Asn Asn  Val Asn Asn 
    1940                 1945                 1950             


Pro Val  Met Leu Leu Asp Thr  Phe Asp Phe Gly Pro  Arg Glu Asp 
    1955                 1960                 1965             


Asn Trp  Phe Phe Tyr Pro Gly  Gly Asn Ile Gly Leu  Tyr Cys Pro 
    1970                 1975                 1980             


Tyr Ser  Ser Lys Gly Ala Pro  Glu Glu Asp Ser Ala  Met Val Phe 
    1985                 1990                 1995             


Val Ser  Asn Glu Val Gly Glu  His Ser Ile Thr Thr  Arg Asp Leu 
    2000                 2005                 2010             


Asn Val  Asn Glu Asn Thr Ile  Ile Gln Phe Glu Ile  Asn Val Gly 
    2015                 2020                 2025             


Cys Ser  Thr Asp Ser Ser Ser  Ala Asp Pro Val Arg  Leu Glu Phe 
    2030                 2035                 2040             


Ser Arg  Asp Phe Gly Ala Thr  Trp His Leu Leu Leu  Pro Leu Cys 
    2045                 2050                 2055             


Tyr His  Ser Ser Ser His Val  Ser Ser Leu Cys Ser  Thr Glu His 
    2060                 2065                 2070             


His Pro  Ser Ser Thr Tyr Tyr  Ala Gly Thr Met Gln  Gly Trp Arg 
    2075                 2080                 2085             


Arg Glu  Val Val His Phe Gly  Lys Leu His Leu Cys  Gly Ser Val 
    2090                 2095                 2100             


Arg Phe  Arg Trp Tyr Gln Gly  Phe Tyr Pro Ala Gly  Ser Gln Pro 
    2105                 2110                 2115             


Val Thr  Trp Ala Ile Asp Asn  Val Tyr Ile Gly Pro  Gln Cys Glu 
    2120                 2125                 2130             


Glu Met  Cys Asn Gly Gln Gly  Ser Cys Ile Asn Gly  Thr Lys Cys 
    2135                 2140                 2145             


Ile Cys  Asp Pro Gly Tyr Ser  Gly Pro Thr Cys Lys  Ile Ser Thr 
    2150                 2155                 2160             


Lys Asn  Pro Asp Phe Leu Lys  Asp Asp Phe Glu Gly  Gln Leu Glu 
    2165                 2170                 2175             


Ser Asp  Arg Phe Leu Leu Met  Ser Gly Gly Lys Pro  Ser Arg Lys 
    2180                 2185                 2190             


Cys Gly  Ile Leu Ser Ser Gly  Asn Asn Leu Phe Phe  Asn Glu Asp 
    2195                 2200                 2205             


Gly Leu  Arg Met Leu Met Thr  Arg Asp Leu Asp Leu  Ser His Ala 
    2210                 2215                 2220             


Arg Phe  Val Gln Phe Phe Met  Arg Leu Gly Cys Gly  Lys Gly Val 
    2225                 2230                 2235             


Pro Asp  Pro Arg Ser Gln Pro  Val Leu Leu Gln Tyr  Ser Leu Asn 
    2240                 2245                 2250             


Gly Gly  Leu Ser Trp Ser Leu  Leu Gln Glu Phe Leu  Phe Ser Asn 
    2255                 2260                 2265             


Ser Ser  Asn Val Gly Arg Tyr  Ile Ala Leu Glu Ile  Pro Leu Lys 
    2270                 2275                 2280             


Ala Arg  Ser Gly Ser Thr Arg  Leu Arg Trp Trp Gln  Pro Ser Glu 
    2285                 2290                 2295             


Asn Gly  His Phe Tyr Ser Pro  Trp Val Ile Asp Gln  Ile Leu Ile 
    2300                 2305                 2310             


Gly Gly  Asn Ile Ser Gly Asn  Thr Val Leu Glu Asp  Asp Phe Thr 
    2315                 2320                 2325             


Thr Leu  Asp Ser Arg Lys Trp  Leu Leu His Pro Gly  Gly Thr Lys 
    2330                 2335                 2340             


Met Pro  Val Cys Gly Ser Thr  Gly Asp Ala Leu Val  Phe Ile Glu 
    2345                 2350                 2355             


Lys Ala  Ser Thr Arg Tyr Val  Val Ser Thr Asp Val  Ala Val Asn 
    2360                 2365                 2370             


Glu Asp  Ser Phe Leu Gln Ile  Asp Phe Ala Ala Ser  Cys Ser Val 
    2375                 2380                 2385             


Thr Asp  Ser Cys Tyr Ala Ile  Glu Leu Glu Tyr Ser  Val Asp Leu 
    2390                 2395                 2400             


Gly Leu  Ser Trp His Pro Leu  Val Arg Asp Cys Leu  Pro Thr Asn 
    2405                 2410                 2415             


Val Glu  Cys Ser Arg Tyr His  Leu Gln Arg Ile Leu  Val Ser Asp 
    2420                 2425                 2430             


Thr Phe  Asn Lys Trp Thr Arg  Ile Thr Leu Pro Leu  Pro Pro Tyr 
    2435                 2440                 2445             


Thr Arg  Ser Gln Ala Thr Arg  Phe Arg Trp His Gln  Pro Ala Pro 
    2450                 2455                 2460             


Phe Asp  Lys Gln Gln Thr Trp  Ala Ile Asp Asn Val  Tyr Ile Gly 
    2465                 2470                 2475             


Asp Gly  Cys Ile Asp Met Cys  Ser Gly His Gly Arg  Cys Ile Gln 
    2480                 2485                 2490             


Gly Asn  Cys Val Cys Asp Glu  Gln Trp Gly Gly Leu  Tyr Cys Asp 
    2495                 2500                 2505             


Asp Pro  Glu Thr Ser Leu Pro  Thr Gln Leu Lys Asp  Asn Phe Asn 
    2510                 2515                 2520             


Arg Ala  Pro Ser Ser Gln Asn  Trp Leu Thr Val Asn  Gly Gly Lys 
    2525                 2530                 2535             


Leu Ser  Thr Val Cys Gly Ala  Val Ala Ser Gly Met  Ala Leu His 
    2540                 2545                 2550             


Phe Ser  Gly Gly Cys Ser Arg  Leu Leu Val Thr Val  Asp Leu Asn 
    2555                 2560                 2565             


Leu Thr  Asn Ala Glu Phe Ile  Gln Phe Tyr Phe Met  Tyr Gly Cys 
    2570                 2575                 2580             


Leu Ile  Thr Pro Asn Asn Arg  Asn Gln Gly Val Leu  Leu Glu Tyr 
    2585                 2590                 2595             


Ser Val  Asn Gly Gly Ile Thr  Trp Asn Leu Leu Met  Glu Ile Phe 
    2600                 2605                 2610             


Tyr Asp  Gln Tyr Ser Lys Pro  Gly Phe Val Asn Ile  Leu Leu Pro 
    2615                 2620                 2625             


Pro Asp  Ala Lys Glu Ile Ala  Thr Arg Phe Arg Trp  Trp Gln Pro 
    2630                 2635                 2640             


Arg His  Asp Gly Leu Asp Gln  Asn Asp Trp Ala Ile  Asp Asn Val 
    2645                 2650                 2655             


Leu Ile  Ser Gly Ser Ala Asp  Gln Arg Thr Val Met  Leu Asp Thr 
    2660                 2665                 2670             


Phe Ser  Ser Ala Pro Val Pro  Gln His Glu Arg Ser  Pro Ala Asp 
    2675                 2680                 2685             


Ala Gly  Pro Val Gly Arg Ile  Ala Phe Asp Met Phe  Met Glu Asp 
    2690                 2695                 2700             


Lys Thr  Ser Val Asn Glu His  Trp Leu Phe His Asp  Asp Cys Thr 
    2705                 2710                 2715             


Val Glu  Arg Phe Cys Asp Ser  Pro Asp Gly Val Met  Leu Cys Gly 
    2720                 2725                 2730             


Ser His  Asp Gly Arg Glu Val  Tyr Ala Val Thr His  Asp Leu Thr 
    2735                 2740                 2745             


Pro Thr  Glu Gly Trp Ile Met  Gln Phe Lys Ile Ser  Val Gly Cys 
    2750                 2755                 2760             


Lys Val  Ser Glu Lys Ile Ala  Gln Asn Gln Ile His  Val Gln Tyr 
    2765                 2770                 2775             


Ser Thr  Asp Phe Gly Val Ser  Trp Asn Tyr Leu Val  Pro Gln Cys 
    2780                 2785                 2790             


Leu Pro  Ala Asp Pro Lys Cys  Ser Gly Ser Val Ser  Gln Pro Ser 
    2795                 2800                 2805             


Val Phe  Phe Pro Thr Lys Gly  Trp Lys Arg Ile Thr  Tyr Pro Leu 
    2810                 2815                 2820             


Pro Glu  Ser Leu Val Gly Asn  Pro Val Arg Phe Arg  Phe Tyr Gln 
    2825                 2830                 2835             


Lys Tyr  Ser Asp Met Gln Trp  Ala Ile Asp Asn Phe  Tyr Leu Gly 
    2840                 2845                 2850             


Pro Gly  Cys Leu Asp Asn Cys  Arg Gly His Gly Asp  Cys Leu Arg 
    2855                 2860                 2865             


Glu Gln  Cys Ile Cys Asp Pro  Gly Tyr Ser Gly Pro  Asn Cys Tyr 
    2870                 2875                 2880             


Leu Thr  His Thr Leu Lys Thr  Phe Leu Lys Glu Arg  Phe Asp Ser 
    2885                 2890                 2895             


Glu Glu  Ile Lys Pro Asp Leu  Trp Met Ser Leu Glu  Gly Gly Ser 
    2900                 2905                 2910             


Thr Cys  Thr Glu Cys Gly Ile  Leu Ala Glu Asp Thr  Ala Leu Tyr 
    2915                 2920                 2925             


Phe Gly  Gly Ser Thr Val Arg  Gln Ala Val Thr Gln  Asp Leu Asp 
    2930                 2935                 2940             


Leu Arg  Gly Ala Lys Phe Leu  Gln Tyr Trp Gly Arg  Ile Gly Ser 
    2945                 2950                 2955             


Glu Asn  Asn Met Thr Ser Cys  His Arg Pro Ile Cys  Arg Lys Glu 
    2960                 2965                 2970             


Gly Val  Leu Leu Asp Tyr Ser  Thr Asp Gly Gly Ile  Thr Trp Thr 
    2975                 2980                 2985             


Leu Leu  His Glu Met Asp Tyr  Gln Lys Tyr Ile Ser  Val Arg His 
    2990                 2995                 3000             


Asp Tyr  Ile Leu Leu Pro Glu  Asp Ala Leu Thr Asn  Thr Thr Arg 
    3005                 3010                 3015             


Leu Arg  Trp Trp Gln Pro Phe  Val Ile Ser Asn Gly  Ile Val Val 
    3020                 3025                 3030             


Ser Gly  Val Glu Arg Ala Gln  Trp Ala Leu Asp Asn  Ile Leu Ile 
    3035                 3040                 3045             


Gly Gly  Ala Glu Ile Asn Pro  Ser Gln Leu Val Asp  Thr Phe Asp 
    3050                 3055                 3060             


Asp Glu  Gly Thr Ser His Glu  Glu Asn Trp Ser Phe  Tyr Pro Asn 
    3065                 3070                 3075             


Ala Val  Arg Thr Ala Gly Phe  Cys Gly Asn Pro Ser  Phe His Leu 
    3080                 3085                 3090             


Tyr Trp  Pro Asn Lys Lys Lys  Asp Lys Thr His Asn  Ala Leu Ser 
    3095                 3100                 3105             


Ser Arg  Glu Leu Ile Ile Gln  Pro Gly Tyr Met Met  Gln Phe Lys 
    3110                 3115                 3120             


Ile Val  Val Gly Cys Glu Ala  Thr Ser Cys Gly Asp  Leu His Ser 
    3125                 3130                 3135             


Val Met  Leu Glu Tyr Thr Lys  Asp Ala Arg Ser Asp  Ser Trp Gln 
    3140                 3145                 3150             


Leu Val  Gln Thr Gln Cys Leu  Pro Ser Ser Ser Asn  Ser Ile Gly 
    3155                 3160                 3165             


Cys Ser  Pro Phe Gln Phe His  Glu Ala Thr Ile Tyr  Asn Ser Val 
    3170                 3175                 3180             


Asn Ser  Ser Ser Trp Lys Arg  Ile Thr Ile Gln Leu  Pro Asp His 
    3185                 3190                 3195             


Val Ser  Ser Ser Ala Thr Gln  Phe Arg Trp Ile Gln  Lys Gly Glu 
    3200                 3205                 3210             


Glu Thr  Glu Lys Gln Ser Trp  Ala Ile Asp His Val  Tyr Ile Gly 
    3215                 3220                 3225             


Glu Ala  Cys Pro Lys Leu Cys  Ser Gly His Gly Tyr  Cys Thr Thr 
    3230                 3235                 3240             


Gly Ala  Ile Cys Ile Cys Asp  Glu Ser Phe Gln Gly  Asp Asp Cys 
    3245                 3250                 3255             


Ser Val  Phe Ser His Asp Leu  Pro Ser Tyr Ile Lys  Asp Asn Phe 
    3260                 3265                 3270             


Glu Ser  Ala Arg Val Thr Glu  Ala Asn Trp Glu Thr  Ile Gln Gly 
    3275                 3280                 3285             


Gly Val  Ile Gly Ser Gly Cys  Gly Gln Leu Ala Pro  Tyr Ala His 
    3290                 3295                 3300             


Gly Asp  Ser Leu Tyr Phe Asn  Gly Cys Gln Ile Arg  Gln Ala Ala 
    3305                 3310                 3315             


Thr Lys  Pro Leu Asp Leu Thr  Arg Ala Ser Lys Ile  Met Phe Val 
    3320                 3325                 3330             


Leu Gln  Ile Gly Ser Met Ser  Gln Thr Asp Ser Cys  Asn Ser Asp 
    3335                 3340                 3345             


Leu Ser  Gly Pro His Ala Val  Asp Lys Ala Val Leu  Leu Gln Tyr 
    3350                 3355                 3360             


Ser Val  Asn Asn Gly Ile Thr  Trp His Val Ile Ala  Gln His Gln 
    3365                 3370                 3375             


Pro Lys  Asp Phe Thr Gln Ala  Gln Arg Val Ser Tyr  Asn Val Pro 
    3380                 3385                 3390             


Leu Glu  Ala Arg Met Lys Gly  Val Leu Leu Arg Trp  Trp Gln Pro 
    3395                 3400                 3405             


Arg His  Asn Gly Thr Gly His  Asp Gln Trp Ala Leu  Asp His Val 
    3410                 3415                 3420             


Glu Val  Val Leu Val Ser Thr  Arg Lys Gln Asn Tyr  Met Met Asn 
    3425                 3430                 3435             


Phe Ser  Arg Gln His Gly Leu  Arg His Phe Tyr Asn  Arg Arg Arg 
    3440                 3445                 3450             


Arg Ser  Leu Arg Arg Tyr Pro  
    3455                 3460 


<210>  2099
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  2099
tcggcggggg cccgctccca ggcccgctcc cgagcccgtt ccgctcccgt ccgccttctt     60

ctcgccttct ctccgcgtgg ctcctccgtc ccggcgtctc caaaactgaa tgagcgagcg    120

gcgcgtaggg cgcgcggcgg cggcggcggc ggcggcggca tggagcgcag tggctgggcc    180

cggcagactt tcctcctagc gctgttgctg ggggcgacgc tgagggcgcg cgcggcggct    240

ggctattacc cccgcttttc gcccttcttt ttcctgtgca cccaccacgg ggagctggaa    300

ggggatgggg agcagggcga ggtgctcatt tccctgcata ttgcgggcaa ccccacctac    360

tacgttccgg gacaagaata ccatgtgaca atttcaacaa gcaccttttt tgacggcttg    420

ctggtgacag gactatacac atctacaagt gttcaggcat cacagagcat tggaggttcc    480

agtgctttcg gatttgggat catgtctgac caccagtttg gtaaccagtt tatgtgcagt    540

gtggtagcct ctcacgtgag tcacctgccc acaaccaacc tcagtttcat ctggattgct    600

ccacctgcgg gcacaggctg tgtgaatttc atggctacag caacacaccg gggccaggtt    660

attttcaaag atgctttagc ccagcagttg tgtgaacaag gagctccaac agatgtcact    720

gtgcacccac atctagctga aatacatagt gacagcatta tcctgagaga tgactttgac    780

tcctaccacc aactgcaatt aaatccaaat atatgggttg aatgtaacaa ctgtgagact    840

ggagaacagt gtggcgcgat tatgcatggc aatgccgtca ccttctgtga accatatggc    900

ccacgagaac tgattaccac aggccttaat acaacaacag cttctgtcct ccaattttcc    960

attgggtcag gttcatgtcg ctttagttat tcagacccca gcatcatcgt gttatatgcc   1020

aagaataact ctgcggactg gattcagcta gagaaaatta gagccccttc caatgtcagc   1080

acaatcatcc atatcctcta ccttcctgag gacgccaaag gggagaatgt ccaatttcag   1140

tggaagcagg aaaatcttcg tgtaggtgaa gtgtatgaag cctgctgggc cttagataac   1200

atcttgatca tcaattcagc tcacagacaa gtcgttttag aagatagtct cgacccagtg   1260

gacacaggca actggctttt cttcccagga gctacagtta agcatagctg tcagtcagat   1320

gggaactcca tttatttcca tggaaatgaa ggcagcgagt tcaattttgc caccaccagg   1380

gatgtagatc tttccacaga agatattcaa gagcaatggt cagaagaatt tgagagccag   1440

cctacaggat gggatgtctt gggagctgtc attggtacag aatgtggaac gatagaatca   1500

ggcttatcaa tggtcttcct caaagatgga gagaggaaat tatgcactcc atccatggac   1560

actaccggtt atgggaacct gaggttttac tttgtgatgg gaggaatttg tgaccctgga   1620

aattctcatg aaaatgacat aatcctgtat gcaaaaattg aaggaagaaa agagcatata   1680

acactggata ccctttccta ttcctcatat aaggttccgt ctttggtttc tgtggtcatc   1740

aatcctgaac ttcagactcc tgctaccaaa ttttgtctca ggcaaaagaa ccatcaagga   1800

cataatagga atgtctgggc tgtagacttt ttccatgtct tgcctgttct cccttctaca   1860

atgtctcaca tgatacagtt ttccatcaat ctgggatgtg gaacgcatca gcctggtaac   1920

agtgtcagct tggaattttc taccaaccat gggcgctcct ggtccctcct tcacactgaa   1980

tgcttacctg agatctgtgc tggaccccac ctcccccaca gcactgtcta ctcctctgaa   2040

aactacagtg ggtggaaccg aataacaatt ccccttccta acgcagcact aacccggaac   2100

accaggattc gctggagaca aacaggacca atccttggaa acatgtgggc aattgataat   2160

gtttatattg gcccgtcatg tctcaaattc tgttctggca gaggacagtg cactagacat   2220

ggttgcaagt gtgaccctgg attttctggc ccagcttgtg agatggcatc ccagacattc   2280

ccaatgttta tttctgaaag ctttggcagt tccaggctct cctcttacca taacttttac   2340

tctatccgtg gtgctgaagt cagctttggt tgtggtgtct tggccagtgg taaggccctg   2400

gttttcaaca aagatgggcg gcgtcagcta attacatctt tccttgacag ctcacaatcc   2460

aggtttctcc agttcacact gagactgggg agcaaatctg ttctgagcac gtgcagagcc   2520

cctgatcagc ctggtgaagg agttttgttg cattattctt atgataatgg gataacttgg   2580

aaactcctgg agcattattc atatctcagc tatcatgagc ccagaataat ctccgtagaa   2640

ctaccaggtg atgcaaagca gtttggaatt cagttcagat ggtggcaacc gtatcattct   2700

tcccagagag aagatgtatg ggctattgat gagattatca tgacatctgt gcttttcaac   2760

agcattagtc ttgactttac caatcttgtg gaggtcactc agtctctggg attctacctt   2820

ggaaatgttc agccatactg tggccacgac tggacccttt gttttacagg agattctaaa   2880

cttgcctcaa gtatgcgcta tgtggaaaca caatcaatgc agataggagc atcctatatg   2940

attcagttca gtttggtgat gggatgtggc cagaaataca ccccacacat ggacaaccag   3000

gtgaagctgg agtactcaac caaccacggc cttacctggc acctcgtcca agaagaatgc   3060

cttccaagta tgccaagttg tcaggaattt acatcagcaa gtatttacca tgccagtgag   3120

tttacacagt ggaggagagt catagtgctt cttccccaga aaacttggtc cagtgctacc   3180

cgtttccgct ggagccagag ctattacaca gctcaagacg agtgggcttt ggacagcatt   3240

tacattgggc agcagtgccc caacatgtgc agtgggcatg gctcatgcga tcatggcata   3300

tgcaggtgtg accaggggta ccaaggcact gaatgccacc cagaagctgc ccttccgtcc   3360

acaattatgt cagattttga gaaccagaat ggctgggagt ctgactggca agaagttatt   3420

gggggagaaa ttgtaaaacc agaacaaggg tgtggtgtca tctcttctgg atcatctctg   3480

tacttcagca aggctgggaa aagacagctg gtgagttggg acctggatac ttcttgggtg   3540

gactttgtcc agttctacat ccagataggc ggagagagtg cttcatgcaa caagcctgac   3600

agcagagagg agggcgtcct ccttcagtac agcaacaatg ggggcatcca gtggcacctg   3660

ctagcagaga tgtacttttc agacttcagc aaacccagat ttgtctatct ggagcttcca   3720

gctgctgcca agaccccttg caccaggttc cgctggtggc agcccgtgtt ctcaggggag   3780

gactatgacc agtgggcagt cgatgacatc atcattctgt ccgagaagca gaagcagatc   3840

atcccagtta tcaatccaac tttacctcag aacttttatg agaagccagc ttttgattac   3900

cctatgaatc agatgagtgt gtggttgatg ttggctaatg aaggaatggt taaaaatgaa   3960

accttctgtg ctgccacacc atcagcaatg atatttggaa aatcagatgg agatcgattt   4020

gcagtaactc gagatttgac cctgaaacct ggatatgtgc tacagttcaa gctaaacata   4080

ggttgtgcca atcaattcag cagtactgct ccagttcttc ttcagtactc tcatgatgct   4140

ggtatgtcct ggtttctggt gaaagaaggc tgttacccgg cttctgcagg caaaggatgc   4200

gaaggaaact ccagagaact aagtgagccc accatgtatc acacagggga ctttgaagaa   4260

tggacaagaa tcaccattgt tattccaagg tctcttgcat ccagcaagac cagattccga   4320

tggatccagg agagcagctc acagaaaaac gtgcctccat ttggtttaga tggagtgtac   4380

atatccgagc cttgtcccag ttactgcagt ggccatgggg actgcatttc aggagtgtgt   4440

ttctgtgacc tgggatatac tgctgcacaa ggaacctgtg tgtcaaatgt ccccaatcac   4500

aatgagatgt tcgataggtt tgaggggaag ctcagccctc tgtggtacaa gataacaggt   4560

gcccaggttg gaactggctg tggaacactt aacgatggca aatctctcta cttcaatggc   4620

cctgggaaaa gggaagcccg gacggtccct ctggacacca ggaatatcag acttgttcaa   4680

ttttatatac aaattggaag caaaacttca ggcattacct gcatcaaacc aagaactaga   4740

aatgaagggc ttattgttca gtattcaaat gacaatggga tactctggca tttgcttcga   4800

gagttggact tcatgtcctt cctggaacca cagatcattt ccattgacct gccacaggac   4860

gcgaagacac ctgcaacggc atttcgatgg tggcaaccgc aacatgggaa gcattcagcc   4920

cagtgggctt tggatgatgt tcttatagga atgaatgaca gctctcaaac tggatttcaa   4980

gacaaatttg atggctctat agatttgcaa gccaactggt atcgaatcca aggaggtcaa   5040

gttgatattg actgtctctc tatggatact gctctgatat tcactgaaaa cataggaaaa   5100

cctcgttatg ctgagacctg ggattttcat gtgtcagcat ctaccttttt gcagtttgaa   5160

atgagcatgg gctgtagcaa gcccttcagc aactcccaca gtgtacagct ccagtattct   5220

ctgaacaatg gcaaggactg gcatcttgtc accgaagagt gtgttcctcc aaccattggc   5280

tgtctgcatt acacggaaag ttcaatttac acctcggaaa gattccagaa ttggaagcgg   5340

atcactgtct accttccact ctccaccatt tctcccagga cccggttcag atggattcag   5400

gccaactaca ctgtgggggc tgattcctgg gcgattgata atgttgtact ggcctcaggg   5460

tgcccttgga tgtgctcagg acgagggatt tgtgatgctg gacgctgtgt gtgtgaccgg   5520

ggctttggtg gaccctattg tgttcctgtt gttcctctgc cctcgattct taaagacgat   5580

ttcaatggga atttacatcc tgacctttgg cctgaagtgt atggtgcaga gagggggaat   5640

ctgaatggtg aaaccatcaa atctggaaca tctctaattt ttaaagggga aggactaagg   5700

atgcttattt caagagatct agattgtaca aatacaatgt atgtccagtt ttcacttaga   5760

tttatagcaa aaagtacccc agagagatct cactctattc tgttacaatt ctccatcagt   5820

ggaggaatca cttggcacct gatggatgaa ttttactttc ctcaaacaac gaatatactt   5880

ttcatcaatg ttcccttgcc atacactgcc caaaccaatg ctacaagatt cagactctgg   5940

caaccttata ataacggtaa gaaagaagaa atctggattg ttgatgactt cattatcgat   6000

ggaaataatg taaacaaccc tgtgatgctc ttggatacat ttgattttgg gcccagagaa   6060

gacaattggt ttttctatcc tggtggtaac atcggtcttt attgtccata ttcttcaaag   6120

ggggcacctg aagaagattc agctatggtg tttgtttcaa atgaagttgg tgagcattcc   6180

attaccaccc gtgacctaaa tgtgaatgag aacaccatca tacaatttga gatcaacgtt   6240

ggctgttcga ctgatagctc atccgcggat ccagtgagac tggaattttc aagggacttc   6300

ggggcgacct ggcaccttct gctgcccctc tgctaccaca gcagcagcca cgtcagctct   6360

ttatgctcca ccgagcacca ccccagcagc acctactacg caggaaccat gcagggctgg   6420

aggagggagg tcgtgcactt tgggaagctg cacctttgtg gatctgtccg tttcagatgg   6480

taccagggat tttaccctgc cggctctcag ccagtgacat gggccattga taatgtctac   6540

atcggtcccc agtgtgagga gatgtgtaat ggacagggga gctgtatcaa tggaaccaaa   6600

tgtatatgtg accctggcta ctcaggtcca acctgtaaaa taagcaccaa aaatcctgat   6660

tttctcaaag atgatttcga aggtcagcta gaatctgata gattcttatt aatgagtggt   6720

gggaaaccat ctcgaaagtg tggaatcctt tctagtggaa acaacctctt tttcaatgaa   6780

gatggcttgc gcatgttgat gacacgagac ctggatttat cacatgctag atttgtgcag   6840

ttcttcatga gactgggatg tggtaaaggc gttcctgacc ccaggagtca acccgtgctc   6900

ctacagtatt ctctcaacgg tggcctctcg tggagtcttc ttcaggagtt ccttttcagc   6960

aattccagca atgtgggcag gtacattgcc ctggagatac ccttgaaagc ccgttctggt   7020

tctactcgcc ttcgctggtg gcaaccgtct gagaatgggc acttctacag cccctgggtt   7080

atcgatcaga ttcttattgg aggaaatatt tctggtaata cggtcttgga agatgatttc   7140

acaacccttg atagtaggaa atggctgctt cacccaggag gcaccaagat gcccgtgtgt   7200

ggctctactg gtgatgccct ggtcttcatt gaaaaggcca gcacccgtta cgtggtcagc   7260

acagacgttg ccgtgaatga ggattccttc ctacagatag acttcgctgc ctcctgctca   7320

gtcacagact cttgttatgc gattgaattg gaatactcag tagatcttgg attgtcatgg   7380

cacccattgg taagggactg tctgcctacc aatgtggaat gcagtcgcta tcatctgcaa   7440

cggatcctgg tgtcagacac tttcaacaag tggactagaa tcactctgcc tctccctcct   7500

tataccaggt cccaagccac tcgtttccgt tggcatcaac cagctccttt tgacaagcag   7560

cagacatggg caatagataa tgtctatatc ggggatggct gcatagacat gtgcagtggc   7620

catgggagat gcatccaggg aaactgcgtc tgtgatgaac agtggggtgg cctgtactgt   7680

gatgaccccg agacctctct tccaacccaa ctcaaagaca acttcaatcg agctccatcc   7740

agtcagaact ggctgactgt gaacggaggg aaattgagta cagtgtgtgg agccgtggcg   7800

tcgggaatgg ctctccattt cagtgggggt tgtagtcgat tattagtcac tgtggatcta   7860

aacctcacta atgctgagtt catccaattt tacttcatgt atgggtgcct gattacacca   7920

aacaaccgta accaaggtgt tctcttggaa tattctgtca atggaggcat tacctggaac   7980

ctgctcatgg agattttcta tgaccagtac agtaagcccg ggtttgtgaa tatccttctc   8040

cctcctgatg ctaaagagat tgccactcgc ttccgctggt ggcagccaag acatgacggc   8100

ctggatcaga acgactgggc cattgacaat gtcctcatct caggctctgc tgaccaaagg   8160

accgttatgc tggacacctt cagcagcgcc cc                                 8192


<210>  2100
<211>  3458
<212>  PRT
<213>  Homosapiens

<400>  2100

Met Glu Arg Ser Gly Trp Ala Arg Gln Thr Phe Leu Leu Ala Leu Leu 
1               5                   10                  15      


Leu Gly Ala Thr Leu Arg Ala Arg Ala Ala Ala Gly Tyr Tyr Pro Arg 
            20                  25                  30          


Phe Ser Pro Phe Phe Phe Leu Cys Thr His His Gly Glu Leu Glu Gly 
        35                  40                  45              


Asp Gly Glu Gln Gly Glu Val Leu Ile Ser Leu His Ile Ala Gly Asn 
    50                  55                  60                  


Pro Thr Tyr Tyr Val Pro Gly Gln Glu Tyr His Val Thr Ile Ser Thr 
65                  70                  75                  80  


Ser Thr Phe Phe Asp Gly Leu Leu Val Thr Gly Leu Tyr Thr Ser Thr 
                85                  90                  95      


Ser Val Gln Ala Ser Gln Ser Ile Gly Gly Ser Ser Ala Phe Gly Phe 
            100                 105                 110         


Gly Ile Met Ser Asp His Gln Phe Gly Asn Gln Phe Met Cys Ser Val 
        115                 120                 125             


Val Ala Ser His Val Ser His Leu Pro Thr Thr Asn Leu Ser Phe Ile 
    130                 135                 140                 


Trp Ile Ala Pro Pro Ala Gly Thr Gly Cys Val Asn Phe Met Ala Thr 
145                 150                 155                 160 


Ala Thr His Arg Gly Gln Val Ile Phe Lys Asp Ala Leu Ala Gln Gln 
                165                 170                 175     


Leu Cys Glu Gln Gly Ala Pro Thr Asp Val Thr Val His Pro His Leu 
            180                 185                 190         


Ala Glu Ile His Ser Asp Ser Ile Ile Leu Arg Asp Asp Phe Asp Ser 
        195                 200                 205             


Tyr His Gln Leu Gln Leu Asn Pro Asn Ile Trp Val Glu Cys Asn Asn 
    210                 215                 220                 


Cys Glu Thr Gly Glu Gln Cys Gly Ala Ile Met His Gly Asn Ala Val 
225                 230                 235                 240 


Thr Phe Cys Glu Pro Tyr Gly Pro Arg Glu Leu Ile Thr Thr Gly Leu 
                245                 250                 255     


Asn Thr Thr Thr Ala Ser Val Leu Gln Phe Ser Ile Gly Ser Gly Ser 
            260                 265                 270         


Cys Arg Phe Ser Tyr Ser Asp Pro Ser Ile Ile Val Leu Tyr Ala Lys 
        275                 280                 285             


Asn Asn Ser Ala Asp Trp Ile Gln Leu Glu Lys Ile Arg Ala Pro Ser 
    290                 295                 300                 


Asn Val Ser Thr Ile Ile His Ile Leu Tyr Leu Pro Glu Asp Ala Lys 
305                 310                 315                 320 


Gly Glu Asn Val Gln Phe Gln Trp Lys Gln Glu Asn Leu Arg Val Gly 
                325                 330                 335     


Glu Val Tyr Glu Ala Cys Trp Ala Leu Asp Asn Ile Leu Ile Ile Asn 
            340                 345                 350         


Ser Ala His Arg Gln Val Val Leu Glu Asp Ser Leu Asp Pro Val Asp 
        355                 360                 365             


Thr Gly Asn Trp Leu Phe Phe Pro Gly Ala Thr Val Lys His Ser Cys 
    370                 375                 380                 


Gln Ser Asp Gly Asn Ser Ile Tyr Phe His Gly Asn Glu Gly Ser Glu 
385                 390                 395                 400 


Phe Asn Phe Ala Thr Thr Arg Asp Val Asp Leu Ser Thr Glu Asp Ile 
                405                 410                 415     


Gln Glu Gln Trp Ser Glu Glu Phe Glu Ser Gln Pro Thr Gly Trp Asp 
            420                 425                 430         


Val Leu Gly Ala Val Ile Gly Thr Glu Cys Gly Thr Ile Glu Ser Gly 
        435                 440                 445             


Leu Ser Met Val Phe Leu Lys Asp Gly Glu Arg Lys Leu Cys Thr Pro 
    450                 455                 460                 


Ser Met Asp Thr Thr Gly Tyr Gly Asn Leu Arg Phe Tyr Phe Val Met 
465                 470                 475                 480 


Gly Gly Ile Cys Asp Pro Gly Asn Ser His Glu Asn Asp Ile Ile Leu 
                485                 490                 495     


Tyr Ala Lys Ile Glu Gly Arg Lys Glu His Ile Thr Leu Asp Thr Leu 
            500                 505                 510         


Ser Tyr Ser Ser Tyr Lys Val Pro Ser Leu Val Ser Val Val Ile Asn 
        515                 520                 525             


Pro Glu Leu Gln Thr Pro Ala Thr Lys Phe Cys Leu Arg Gln Lys Asn 
    530                 535                 540                 


His Gln Gly His Asn Arg Asn Val Trp Ala Val Asp Phe Phe His Val 
545                 550                 555                 560 


Leu Pro Val Leu Pro Ser Thr Met Ser His Met Ile Gln Phe Ser Ile 
                565                 570                 575     


Asn Leu Gly Cys Gly Thr His Gln Pro Gly Asn Ser Val Ser Leu Glu 
            580                 585                 590         


Phe Ser Thr Asn His Gly Arg Ser Trp Ser Leu Leu His Thr Glu Cys 
        595                 600                 605             


Leu Pro Glu Ile Cys Ala Gly Pro His Leu Pro His Ser Thr Val Tyr 
    610                 615                 620                 


Ser Ser Glu Asn Tyr Ser Gly Trp Asn Arg Ile Thr Ile Pro Leu Pro 
625                 630                 635                 640 


Asn Ala Ala Leu Thr Arg Asn Thr Arg Ile Arg Trp Arg Gln Thr Gly 
                645                 650                 655     


Pro Ile Leu Gly Asn Met Trp Ala Ile Asp Asn Val Tyr Ile Gly Pro 
            660                 665                 670         


Ser Cys Leu Lys Phe Cys Ser Gly Arg Gly Gln Cys Thr Arg His Gly 
        675                 680                 685             


Cys Lys Cys Asp Pro Gly Phe Ser Gly Pro Ala Cys Glu Met Ala Ser 
    690                 695                 700                 


Gln Thr Phe Pro Met Phe Ile Ser Glu Ser Phe Gly Ser Ser Arg Leu 
705                 710                 715                 720 


Ser Ser Tyr His Asn Phe Tyr Ser Ile Arg Gly Ala Glu Val Ser Phe 
                725                 730                 735     


Gly Cys Gly Val Leu Ala Ser Gly Lys Ala Leu Val Phe Asn Lys Asp 
            740                 745                 750         


Gly Arg Arg Gln Leu Ile Thr Ser Phe Leu Asp Ser Ser Gln Ser Arg 
        755                 760                 765             


Phe Leu Gln Phe Thr Leu Arg Leu Gly Ser Lys Ser Val Leu Ser Thr 
    770                 775                 780                 


Cys Arg Ala Pro Asp Gln Pro Gly Glu Gly Val Leu Leu His Tyr Ser 
785                 790                 795                 800 


Tyr Asp Asn Gly Ile Thr Trp Lys Leu Leu Glu His Tyr Ser Tyr Leu 
                805                 810                 815     


Ser Tyr His Glu Pro Arg Ile Ile Ser Val Glu Leu Pro Gly Asp Ala 
            820                 825                 830         


Lys Gln Phe Gly Ile Gln Phe Arg Trp Trp Gln Pro Tyr His Ser Ser 
        835                 840                 845             


Gln Arg Glu Asp Val Trp Ala Ile Asp Glu Ile Ile Met Thr Ser Val 
    850                 855                 860                 


Leu Phe Asn Ser Ile Ser Leu Asp Phe Thr Asn Leu Val Glu Val Thr 
865                 870                 875                 880 


Gln Ser Leu Gly Phe Tyr Leu Gly Asn Val Gln Pro Tyr Cys Gly His 
                885                 890                 895     


Asp Trp Thr Leu Cys Phe Thr Gly Asp Ser Lys Leu Ala Ser Ser Met 
            900                 905                 910         


Arg Tyr Val Glu Thr Gln Ser Met Gln Ile Gly Ala Ser Tyr Met Ile 
        915                 920                 925             


Gln Phe Ser Leu Val Met Gly Cys Gly Gln Lys Tyr Thr Pro His Met 
    930                 935                 940                 


Asp Asn Gln Val Lys Leu Glu Tyr Ser Thr Asn His Gly Leu Thr Trp 
945                 950                 955                 960 


His Leu Val Gln Glu Glu Cys Leu Pro Ser Met Pro Ser Cys Gln Glu 
                965                 970                 975     


Phe Thr Ser Ala Ser Ile Tyr His Ala Ser Glu Phe Thr Gln Trp Arg 
            980                 985                 990         


Arg Val Ile Val Leu Leu Pro Gln  Lys Thr Trp Ser Ser  Ala Thr Arg 
        995                 1000                 1005             


Phe Arg  Trp Ser Gln Ser Tyr  Tyr Thr Ala Gln Asp  Glu Trp Ala 
    1010                 1015                 1020             


Leu Asp  Ser Ile Tyr Ile Gly  Gln Gln Cys Pro Asn  Met Cys Ser 
    1025                 1030                 1035             


Gly His  Gly Ser Cys Asp His  Gly Ile Cys Arg Cys  Asp Gln Gly 
    1040                 1045                 1050             


Tyr Gln  Gly Thr Glu Cys His  Pro Glu Ala Ala Leu  Pro Ser Thr 
    1055                 1060                 1065             


Ile Met  Ser Asp Phe Glu Asn  Gln Asn Gly Trp Glu  Ser Asp Trp 
    1070                 1075                 1080             


Gln Glu  Val Ile Gly Gly Glu  Ile Val Lys Pro Glu  Gln Gly Cys 
    1085                 1090                 1095             


Gly Val  Ile Ser Ser Gly Ser  Ser Leu Tyr Phe Ser  Lys Ala Gly 
    1100                 1105                 1110             


Lys Arg  Gln Leu Val Ser Trp  Asp Leu Asp Thr Ser  Trp Val Asp 
    1115                 1120                 1125             


Phe Val  Gln Phe Tyr Ile Gln  Ile Gly Gly Glu Ser  Ala Ser Cys 
    1130                 1135                 1140             


Asn Lys  Pro Asp Ser Arg Glu  Glu Gly Val Leu Leu  Gln Tyr Ser 
    1145                 1150                 1155             


Asn Asn  Gly Gly Ile Gln Trp  His Leu Leu Ala Glu  Met Tyr Phe 
    1160                 1165                 1170             


Ser Asp  Phe Ser Lys Pro Arg  Phe Val Tyr Leu Glu  Leu Pro Ala 
    1175                 1180                 1185             


Ala Ala  Lys Thr Pro Cys Thr  Arg Phe Arg Trp Trp  Gln Pro Val 
    1190                 1195                 1200             


Phe Ser  Gly Glu Asp Tyr Asp  Gln Trp Ala Val Asp  Asp Ile Ile 
    1205                 1210                 1215             


Ile Leu  Ser Glu Lys Gln Lys  Gln Ile Ile Pro Val  Ile Asn Pro 
    1220                 1225                 1230             


Thr Leu  Pro Gln Asn Phe Tyr  Glu Lys Pro Ala Phe  Asp Tyr Pro 
    1235                 1240                 1245             


Met Asn  Gln Met Ser Val Trp  Leu Met Leu Ala Asn  Glu Gly Met 
    1250                 1255                 1260             


Val Lys  Asn Glu Thr Phe Cys  Ala Ala Thr Pro Ser  Ala Met Ile 
    1265                 1270                 1275             


Phe Gly  Lys Ser Asp Gly Asp  Arg Phe Ala Val Thr  Arg Asp Leu 
    1280                 1285                 1290             


Thr Leu  Lys Pro Gly Tyr Val  Leu Gln Phe Lys Leu  Asn Ile Gly 
    1295                 1300                 1305             


Cys Ala  Asn Gln Phe Ser Ser  Thr Ala Pro Val Leu  Leu Gln Tyr 
    1310                 1315                 1320             


Ser His  Asp Ala Gly Met Ser  Trp Phe Leu Val Lys  Glu Gly Cys 
    1325                 1330                 1335             


Tyr Pro  Ala Ser Ala Gly Lys  Gly Cys Glu Gly Asn  Ser Arg Glu 
    1340                 1345                 1350             


Leu Ser  Glu Pro Thr Met Tyr  His Thr Gly Asp Phe  Glu Glu Trp 
    1355                 1360                 1365             


Thr Arg  Ile Thr Ile Val Ile  Pro Arg Ser Leu Ala  Ser Ser Lys 
    1370                 1375                 1380             


Thr Arg  Phe Arg Trp Ile Gln  Glu Ser Ser Ser Gln  Lys Asn Val 
    1385                 1390                 1395             


Pro Pro  Phe Gly Leu Asp Gly  Val Tyr Ile Ser Glu  Pro Cys Pro 
    1400                 1405                 1410             


Ser Tyr  Cys Ser Gly His Gly  Asp Cys Ile Ser Gly  Val Cys Phe 
    1415                 1420                 1425             


Cys Asp  Leu Gly Tyr Thr Ala  Ala Gln Gly Thr Cys  Val Ser Asn 
    1430                 1435                 1440             


Val Pro  Asn His Asn Glu Met  Phe Asp Arg Phe Glu  Gly Lys Leu 
    1445                 1450                 1455             


Ser Pro  Leu Trp Tyr Lys Ile  Thr Gly Ala Gln Val  Gly Thr Gly 
    1460                 1465                 1470             


Cys Gly  Thr Leu Asn Asp Gly  Lys Ser Leu Tyr Phe  Asn Gly Pro 
    1475                 1480                 1485             


Gly Lys  Arg Glu Ala Arg Thr  Val Pro Leu Asp Thr  Arg Asn Ile 
    1490                 1495                 1500             


Arg Leu  Val Gln Phe Tyr Ile  Gln Ile Gly Ser Lys  Thr Ser Gly 
    1505                 1510                 1515             


Ile Thr  Cys Ile Lys Pro Arg  Thr Arg Asn Glu Gly  Leu Ile Val 
    1520                 1525                 1530             


Gln Tyr  Ser Asn Asp Asn Gly  Ile Leu Trp His Leu  Leu Arg Glu 
    1535                 1540                 1545             


Leu Asp  Phe Met Ser Phe Leu  Glu Pro Gln Ile Ile  Ser Ile Asp 
    1550                 1555                 1560             


Leu Pro  Gln Asp Ala Lys Thr  Pro Ala Thr Ala Phe  Arg Trp Trp 
    1565                 1570                 1575             


Gln Pro  Gln His Gly Lys His  Ser Ala Gln Trp Ala  Leu Asp Asp 
    1580                 1585                 1590             


Val Leu  Ile Gly Met Asn Asp  Ser Ser Gln Thr Gly  Phe Gln Asp 
    1595                 1600                 1605             


Lys Phe  Asp Gly Ser Ile Asp  Leu Gln Ala Asn Trp  Tyr Arg Ile 
    1610                 1615                 1620             


Gln Gly  Gly Gln Val Asp Ile  Asp Cys Leu Ser Met  Asp Thr Ala 
    1625                 1630                 1635             


Leu Ile  Phe Thr Glu Asn Ile  Gly Lys Pro Arg Tyr  Ala Glu Thr 
    1640                 1645                 1650             


Trp Asp  Phe His Val Ser Ala  Ser Thr Phe Leu Gln  Phe Glu Met 
    1655                 1660                 1665             


Ser Met  Gly Cys Ser Lys Pro  Phe Ser Asn Ser His  Ser Val Gln 
    1670                 1675                 1680             


Leu Gln  Tyr Ser Leu Asn Asn  Gly Lys Asp Trp His  Leu Val Thr 
    1685                 1690                 1695             


Glu Glu  Cys Val Pro Pro Thr  Ile Gly Cys Leu His  Tyr Thr Glu 
    1700                 1705                 1710             


Ser Ser  Ile Tyr Thr Ser Glu  Arg Phe Gln Asn Trp  Lys Arg Ile 
    1715                 1720                 1725             


Thr Val  Tyr Leu Pro Leu Ser  Thr Ile Ser Pro Arg  Thr Arg Phe 
    1730                 1735                 1740             


Arg Trp  Ile Gln Ala Asn Tyr  Thr Val Gly Ala Asp  Ser Trp Ala 
    1745                 1750                 1755             


Ile Asp  Asn Val Val Leu Ala  Ser Gly Cys Pro Trp  Met Cys Ser 
    1760                 1765                 1770             


Gly Arg  Gly Ile Cys Asp Ala  Gly Arg Cys Val Cys  Asp Arg Gly 
    1775                 1780                 1785             


Phe Gly  Gly Pro Tyr Cys Val  Pro Val Val Pro Leu  Pro Ser Ile 
    1790                 1795                 1800             


Leu Lys  Asp Asp Phe Asn Gly  Asn Leu His Pro Asp  Leu Trp Pro 
    1805                 1810                 1815             


Glu Val  Tyr Gly Ala Glu Arg  Gly Asn Leu Asn Gly  Glu Thr Ile 
    1820                 1825                 1830             


Lys Ser  Gly Thr Ser Leu Ile  Phe Lys Gly Glu Gly  Leu Arg Met 
    1835                 1840                 1845             


Leu Ile  Ser Arg Asp Leu Asp  Cys Thr Asn Thr Met  Tyr Val Gln 
    1850                 1855                 1860             


Phe Ser  Leu Arg Phe Ile Ala  Lys Ser Thr Pro Glu  Arg Ser His 
    1865                 1870                 1875             


Ser Ile  Leu Leu Gln Phe Ser  Ile Ser Gly Gly Ile  Thr Trp His 
    1880                 1885                 1890             


Leu Met  Asp Glu Phe Tyr Phe  Pro Gln Thr Thr Asn  Ile Leu Phe 
    1895                 1900                 1905             


Ile Asn  Val Pro Leu Pro Tyr  Thr Ala Gln Thr Asn  Ala Thr Arg 
    1910                 1915                 1920             


Phe Arg  Leu Trp Gln Pro Tyr  Asn Asn Gly Lys Lys  Glu Glu Ile 
    1925                 1930                 1935             


Trp Ile  Val Asp Asp Phe Ile  Ile Asp Gly Asn Asn  Val Asn Asn 
    1940                 1945                 1950             


Pro Val  Met Leu Leu Asp Thr  Phe Asp Phe Gly Pro  Arg Glu Asp 
    1955                 1960                 1965             


Asn Trp  Phe Phe Tyr Pro Gly  Gly Asn Ile Gly Leu  Tyr Cys Pro 
    1970                 1975                 1980             


Tyr Ser  Ser Lys Gly Ala Pro  Glu Glu Asp Ser Ala  Met Val Phe 
    1985                 1990                 1995             


Val Ser  Asn Glu Val Gly Glu  His Ser Ile Thr Thr  Arg Asp Leu 
    2000                 2005                 2010             


Asn Val  Asn Glu Asn Thr Ile  Ile Gln Phe Glu Ile  Asn Val Gly 
    2015                 2020                 2025             


Cys Ser  Thr Asp Ser Ser Ser  Ala Asp Pro Val Arg  Leu Glu Phe 
    2030                 2035                 2040             


Ser Arg  Asp Phe Gly Ala Thr  Trp His Leu Leu Leu  Pro Leu Cys 
    2045                 2050                 2055             


Tyr His  Ser Ser Ser His Val  Ser Ser Leu Cys Ser  Thr Glu His 
    2060                 2065                 2070             


His Pro  Ser Ser Thr Tyr Tyr  Ala Gly Thr Met Gln  Gly Trp Arg 
    2075                 2080                 2085             


Arg Glu  Val Val His Phe Gly  Lys Leu His Leu Cys  Gly Ser Val 
    2090                 2095                 2100             


Arg Phe  Arg Trp Tyr Gln Gly  Phe Tyr Pro Ala Gly  Ser Gln Pro 
    2105                 2110                 2115             


Val Thr  Trp Ala Ile Asp Asn  Val Tyr Ile Gly Pro  Gln Cys Glu 
    2120                 2125                 2130             


Glu Met  Cys Asn Gly Gln Gly  Ser Cys Ile Asn Gly  Thr Lys Cys 
    2135                 2140                 2145             


Ile Cys  Asp Pro Gly Tyr Ser  Gly Pro Thr Cys Lys  Ile Ser Thr 
    2150                 2155                 2160             


Lys Asn  Pro Asp Phe Leu Lys  Asp Asp Phe Glu Gly  Gln Leu Glu 
    2165                 2170                 2175             


Ser Asp  Arg Phe Leu Leu Met  Ser Gly Gly Lys Pro  Ser Arg Lys 
    2180                 2185                 2190             


Cys Gly  Ile Leu Ser Ser Gly  Asn Asn Leu Phe Phe  Asn Glu Asp 
    2195                 2200                 2205             


Gly Leu  Arg Met Leu Met Thr  Arg Asp Leu Asp Leu  Ser His Ala 
    2210                 2215                 2220             


Arg Phe  Val Gln Phe Phe Met  Arg Leu Gly Cys Gly  Lys Gly Val 
    2225                 2230                 2235             


Pro Asp  Pro Arg Ser Gln Pro  Val Leu Leu Gln Tyr  Ser Leu Asn 
    2240                 2245                 2250             


Gly Gly  Leu Ser Trp Ser Leu  Leu Gln Glu Phe Leu  Phe Ser Asn 
    2255                 2260                 2265             


Ser Ser  Asn Val Gly Arg Tyr  Ile Ala Leu Glu Ile  Pro Leu Lys 
    2270                 2275                 2280             


Ala Arg  Ser Gly Ser Thr Arg  Leu Arg Trp Trp Gln  Pro Ser Glu 
    2285                 2290                 2295             


Asn Gly  His Phe Tyr Ser Pro  Trp Val Ile Asp Gln  Ile Leu Ile 
    2300                 2305                 2310             


Gly Gly  Asn Ile Ser Gly Asn  Thr Val Leu Glu Asp  Asp Phe Thr 
    2315                 2320                 2325             


Thr Leu  Asp Ser Arg Lys Trp  Leu Leu His Pro Gly  Gly Thr Lys 
    2330                 2335                 2340             


Met Pro  Val Cys Gly Ser Thr  Gly Asp Ala Leu Val  Phe Ile Glu 
    2345                 2350                 2355             


Lys Ala  Ser Thr Arg Tyr Val  Val Ser Thr Asp Val  Ala Val Asn 
    2360                 2365                 2370             


Glu Asp  Ser Phe Leu Gln Ile  Asp Phe Ala Ala Ser  Cys Ser Val 
    2375                 2380                 2385             


Thr Asp  Ser Cys Tyr Ala Ile  Glu Leu Glu Tyr Ser  Val Asp Leu 
    2390                 2395                 2400             


Gly Leu  Ser Trp His Pro Leu  Val Arg Asp Cys Leu  Pro Thr Asn 
    2405                 2410                 2415             


Val Glu  Cys Ser Arg Tyr His  Leu Gln Arg Ile Leu  Val Ser Asp 
    2420                 2425                 2430             


Thr Phe  Asn Lys Trp Thr Arg  Ile Thr Leu Pro Leu  Pro Pro Tyr 
    2435                 2440                 2445             


Thr Arg  Ser Gln Ala Thr Arg  Phe Arg Trp His Gln  Pro Ala Pro 
    2450                 2455                 2460             


Phe Asp  Lys Gln Gln Thr Trp  Ala Ile Asp Asn Val  Tyr Ile Gly 
    2465                 2470                 2475             


Asp Gly  Cys Ile Asp Met Cys  Ser Gly His Gly Arg  Cys Ile Gln 
    2480                 2485                 2490             


Gly Asn  Cys Val Cys Asp Glu  Gln Trp Gly Gly Leu  Tyr Cys Asp 
    2495                 2500                 2505             


Asp Pro  Glu Thr Ser Leu Pro  Thr Gln Leu Lys Asp  Asn Phe Asn 
    2510                 2515                 2520             


Arg Ala  Pro Ser Ser Gln Asn  Trp Leu Thr Val Asn  Gly Gly Lys 
    2525                 2530                 2535             


Leu Ser  Thr Val Cys Gly Ala  Val Ala Ser Gly Met  Ala Leu His 
    2540                 2545                 2550             


Phe Ser  Gly Gly Cys Ser Arg  Leu Leu Val Thr Val  Asp Leu Asn 
    2555                 2560                 2565             


Leu Thr  Asn Ala Glu Phe Ile  Gln Phe Tyr Phe Met  Tyr Gly Cys 
    2570                 2575                 2580             


Leu Ile  Thr Pro Asn Asn Arg  Asn Gln Gly Val Leu  Leu Glu Tyr 
    2585                 2590                 2595             


Ser Val  Asn Gly Gly Ile Thr  Trp Asn Leu Leu Met  Glu Ile Phe 
    2600                 2605                 2610             


Tyr Asp  Gln Tyr Ser Lys Pro  Gly Phe Val Asn Ile  Leu Leu Pro 
    2615                 2620                 2625             


Pro Asp  Ala Lys Glu Ile Ala  Thr Arg Phe Arg Trp  Trp Gln Pro 
    2630                 2635                 2640             


Arg His  Asp Gly Leu Asp Gln  Asn Asp Trp Ala Ile  Asp Asn Val 
    2645                 2650                 2655             


Leu Ile  Ser Gly Ser Ala Asp  Gln Arg Thr Val Met  Leu Asp Thr 
    2660                 2665                 2670             


Phe Ser  Ser Ala Pro Val Pro  Gln His Glu Arg Ser  Pro Ala Asp 
    2675                 2680                 2685             


Ala Gly  Pro Val Gly Arg Ile  Ala Phe Asp Met Phe  Met Glu Asp 
    2690                 2695                 2700             


Lys Thr  Ser Val Asn Glu His  Trp Leu Phe His Asp  Asp Cys Thr 
    2705                 2710                 2715             


Val Glu  Arg Phe Cys Asp Ser  Pro Asp Gly Val Met  Leu Cys Gly 
    2720                 2725                 2730             


Ser His  Asp Gly Arg Glu Val  Tyr Ala Val Thr His  Asp Leu Thr 
    2735                 2740                 2745             


Pro Thr  Glu Gly Trp Ile Met  Gln Phe Lys Ile Ser  Val Gly Cys 
    2750                 2755                 2760             


Lys Val  Ser Glu Lys Ile Ala  Gln Asn Gln Ile His  Val Gln Tyr 
    2765                 2770                 2775             


Ser Thr  Asp Phe Gly Val Ser  Trp Asn Tyr Leu Val  Pro Gln Cys 
    2780                 2785                 2790             


Leu Pro  Ala Asp Pro Lys Cys  Ser Gly Ser Val Ser  Gln Pro Ser 
    2795                 2800                 2805             


Val Phe  Phe Pro Thr Lys Gly  Trp Lys Arg Ile Thr  Tyr Pro Leu 
    2810                 2815                 2820             


Pro Glu  Ser Leu Val Gly Asn  Pro Val Arg Phe Arg  Phe Tyr Gln 
    2825                 2830                 2835             


Lys Tyr  Ser Asp Met Gln Trp  Ala Ile Asp Asn Phe  Tyr Leu Gly 
    2840                 2845                 2850             


Pro Gly  Cys Leu Asp Asn Cys  Arg Gly His Gly Asp  Cys Leu Arg 
    2855                 2860                 2865             


Glu Gln  Cys Ile Cys Asp Pro  Gly Tyr Ser Gly Pro  Asn Cys Tyr 
    2870                 2875                 2880             


Leu Thr  His Thr Leu Lys Thr  Phe Leu Lys Glu Arg  Phe Asp Ser 
    2885                 2890                 2895             


Glu Glu  Ile Lys Pro Asp Leu  Trp Met Ser Leu Glu  Gly Gly Ser 
    2900                 2905                 2910             


Thr Cys  Thr Glu Cys Gly Ile  Leu Ala Glu Asp Thr  Ala Leu Tyr 
    2915                 2920                 2925             


Phe Gly  Gly Ser Thr Val Arg  Gln Ala Val Thr Gln  Asp Leu Asp 
    2930                 2935                 2940             


Leu Arg  Gly Ala Lys Phe Leu  Gln Tyr Trp Gly Arg  Ile Gly Ser 
    2945                 2950                 2955             


Glu Asn  Asn Met Thr Ser Cys  His Arg Pro Ile Cys  Arg Lys Glu 
    2960                 2965                 2970             


Gly Val  Leu Leu Asp Tyr Ser  Thr Asp Gly Gly Ile  Thr Trp Thr 
    2975                 2980                 2985             


Leu Leu  His Glu Met Asp Tyr  Gln Lys Tyr Ile Ser  Val Arg His 
    2990                 2995                 3000             


Asp Tyr  Ile Leu Leu Pro Glu  Asp Ala Leu Thr Asn  Thr Thr Arg 
    3005                 3010                 3015             


Leu Arg  Trp Trp Gln Pro Phe  Val Ile Ser Asn Gly  Ile Val Val 
    3020                 3025                 3030             


Ser Gly  Val Glu Arg Ala Gln  Trp Ala Leu Asp Asn  Ile Leu Ile 
    3035                 3040                 3045             


Gly Gly  Ala Glu Ile Asn Pro  Ser Gln Leu Val Asp  Thr Phe Asp 
    3050                 3055                 3060             


Asp Glu  Gly Thr Ser His Glu  Glu Asn Trp Ser Phe  Tyr Pro Asn 
    3065                 3070                 3075             


Ala Val  Arg Thr Ala Gly Phe  Cys Gly Asn Pro Ser  Phe His Leu 
    3080                 3085                 3090             


Tyr Trp  Pro Asn Lys Lys Lys  Asp Lys Thr His Asn  Ala Leu Ser 
    3095                 3100                 3105             


Ser Arg  Glu Leu Ile Ile Gln  Pro Gly Tyr Met Met  Gln Phe Lys 
    3110                 3115                 3120             


Ile Val  Val Gly Cys Glu Ala  Thr Ser Cys Gly Asp  Leu His Ser 
    3125                 3130                 3135             


Val Met  Leu Glu Tyr Thr Lys  Asp Ala Arg Ser Asp  Ser Trp Gln 
    3140                 3145                 3150             


Leu Val  Gln Thr Gln Cys Leu  Pro Ser Ser Ser Asn  Ser Ile Gly 
    3155                 3160                 3165             


Cys Ser  Pro Phe Gln Phe His  Glu Ala Thr Ile Tyr  Asn Ser Val 
    3170                 3175                 3180             


Asn Ser  Ser Ser Trp Lys Arg  Ile Thr Ile Gln Leu  Pro Asp His 
    3185                 3190                 3195             


Val Ser  Ser Ser Ala Thr Gln  Phe Arg Trp Ile Gln  Lys Gly Glu 
    3200                 3205                 3210             


Glu Thr  Glu Lys Gln Ser Trp  Ala Ile Asp His Val  Tyr Ile Gly 
    3215                 3220                 3225             


Glu Ala  Cys Pro Lys Leu Cys  Ser Gly His Gly Tyr  Cys Thr Thr 
    3230                 3235                 3240             


Gly Ala  Ile Cys Ile Cys Asp  Glu Ser Phe Gln Gly  Asp Asp Cys 
    3245                 3250                 3255             


Ser Val  Phe Ser His Asp Leu  Pro Ser Tyr Ile Lys  Asp Asn Phe 
    3260                 3265                 3270             


Glu Ser  Ala Arg Val Thr Glu  Ala Asn Trp Glu Thr  Ile Gln Gly 
    3275                 3280                 3285             


Gly Val  Ile Gly Ser Gly Cys  Gly Gln Leu Ala Pro  Tyr Ala His 
    3290                 3295                 3300             


Gly Asp  Ser Leu Tyr Phe Asn  Gly Cys Gln Ile Arg  Gln Ala Ala 
    3305                 3310                 3315             


Thr Lys  Pro Leu Asp Leu Thr  Arg Ala Ser Lys Ile  Met Phe Val 
    3320                 3325                 3330             


Leu Gln  Ile Gly Ser Met Ser  Gln Thr Asp Ser Cys  Asn Ser Asp 
    3335                 3340                 3345             


Leu Ser  Gly Pro His Ala Val  Asp Lys Ala Val Leu  Leu Gln Tyr 
    3350                 3355                 3360             


Ser Val  Asn Asn Gly Ile Thr  Trp His Val Ile Ala  Gln His Gln 
    3365                 3370                 3375             


Pro Lys  Asp Phe Thr Gln Ala  Gln Arg Val Ser Tyr  Asn Val Pro 
    3380                 3385                 3390             


Leu Glu  Ala Arg Met Lys Gly  Val Leu Leu Arg Trp  Trp Gln Pro 
    3395                 3400                 3405             


Arg His  Asn Gly Thr Gly His  Asp Gln Trp Ala Leu  Asp His Val 
    3410                 3415                 3420             


Glu Val  Val Leu Thr Arg Lys  Gln Asn Tyr Met Met  Asn Phe Ser 
    3425                 3430                 3435             


Arg Gln  His Gly Leu Arg His  Phe Tyr Asn Arg Arg  Arg Arg Ser 
    3440                 3445                 3450             


Leu Arg  Arg Tyr Pro 
    3455             


<210>  2101
<211>  1540
<212>  DNA
<213>  Homosapiens

<400>  2101
cggccgcgag tcctgcgtga tcgcgagcat gtgtgcgtgc gcgtgtttat ctgaggcgcg     60

tgcggcggcc accccagcct agtcctcttc ttggtgccac tggctaacta ggttgagaaa    120

ccggcgccac aggcggcaca cctggcccgg agctggcccg ctcctccccg ccgagccggc    180

gccccaacaa cgcgccctct cccagtcctc acaaaggggc ctagtccggc ccccggctct    240

ggccgtgagg gagcgctgtg ggggcgcgct gccttctgcc tggaagtgtt gggcaggtgg    300

tgggagagcg tcaggcttga acaacatgat tttaaagcac gtgtctgtct gtcgtttttt    360

acttttaggg ttttggccaa attgggcgag ggcacaaaat aaccacttac cccttctcac    420

cgaggaagag cgggagaaag ggtatggcac agtcacaagg gtgggtgaaa agatacatca    480

aggccttttg taaaggcttc tttgtggcgg tgcctgtggc agtgactttc ttggatcggg    540

tcgcctgtgt ggcaagagta gaaggagcat cgatgcagcc ttctttgaat cctgggggga    600

gccagtcatc tgatgtggtg cttttgaacc actggaaagt gaggaatttt gaagtacacc    660

gtggtgacat tgtatcattg gtgtctccta aaaacccaga acagaagatc attaagagag    720

tgattgctct tgaaggagat attgtcagaa ccataggaca caaaaaccgg tatgtcaaag    780

tcccccgtgg tcacatctgg gttgaaggtg atcatcatgg acacagtttt gacagtaatt    840

cttttgggcc ggtttcccta ggacttctgc atgcccatgc cacacatatc ctgtggcccc    900

cagagcgctg gcagaaattg gaatctgttc ttcctccaga gcgcttacca gtacagagag    960

aagaggaatg actgcatgaa tctacctgag ttgctggcat tgggaggcca gttactggaa   1020

aggaatggaa aaaagaagcc tccaaaaggg aaaaacttct gacaatatga tgctgtgcga   1080

gaaatattta cagcacatta aaacgatctg tattattaaa taaataattt tcaaatgtta   1140

aacagtatta aatggcacct gattttgtgt taaattttag ttccctgttg tttaatgccc   1200

ccaaaatatg cagacctttg ggaatataaa aatattgcac ccacatgtct taatggggct   1260

gaatttcaga ttatttgtta catatactta ttatattgat tgttgggttt tgattttggt   1320

gcttgctgct gaaataaatt gaaaattaat attcaataaa aatgatgtat ttgtcacttg   1380

ctgttaaggt agaacaagaa ggaacacata ttatacacat aatgatggga attacattgt   1440

gatttgtact atctacaaag gagtaactgc cagttaggaa gaacagtaaa cagtgatgtt   1500

aaaataaaac aatgatttgt aaaaaaaaaa aaaaaaaaaa                         1540


<210>  2102
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  2102

Met Ala Gln Ser Gln Gly Trp Val Lys Arg Tyr Ile Lys Ala Phe Cys 
1               5                   10                  15      


Lys Gly Phe Phe Val Ala Val Pro Val Ala Val Thr Phe Leu Asp Arg 
            20                  25                  30          


Val Ala Cys Val Ala Arg Val Glu Gly Ala Ser Met Gln Pro Ser Leu 
        35                  40                  45              


Asn Pro Gly Gly Ser Gln Ser Ser Asp Val Val Leu Leu Asn His Trp 
    50                  55                  60                  


Lys Val Arg Asn Phe Glu Val His Arg Gly Asp Ile Val Ser Leu Val 
65                  70                  75                  80  


Ser Pro Lys Asn Pro Glu Gln Lys Ile Ile Lys Arg Val Ile Ala Leu 
                85                  90                  95      


Glu Gly Asp Ile Val Arg Thr Ile Gly His Lys Asn Arg Tyr Val Lys 
            100                 105                 110         


Val Pro Arg Gly His Ile Trp Val Glu Gly Asp His His Gly His Ser 
        115                 120                 125             


Phe Asp Ser Asn Ser Phe Gly Pro Val Ser Leu Gly Leu Leu His Ala 
    130                 135                 140                 


His Ala Thr His Ile Leu Trp Pro Pro Glu Arg Trp Gln Lys Leu Glu 
145                 150                 155                 160 


Ser Val Leu Pro Pro Glu Arg Leu Pro Val Gln Arg Glu Glu Glu 
                165                 170                 175 


<210>  2103
<211>  3389
<212>  DNA
<213>  Homosapiens

<400>  2103
gtcggtgtga caactgatcg ggtgaacgat gcaccactaa ccaccatgga aacaaggaaa     60

aataaagcaa gctcacagga tctctcttca ctggattgag agcctcagcc tgccgactga    120

gaaaaagagt tccaggaaaa agaaggaatc ccggctgcag cctcctgcct tcctttatat    180

tttaaaatag agagataaga ttgcgtgcat gtgtgcatat ctatagtata tattttgtac    240

actttgttac acagacacac aaatgcacct atttataccg ggcaagaaca caaccatgtg    300

attatctcaa ccaaggaact gaggaatcca gcacgcaagg acatcggagg tgggctagca    360

ctgaaactgc ttttcaagca tcatgctgct attcctgcaa atactgaaga agcatgggat    420

ttaaatattt tacttctaaa taaatgaatt actcaatctc ctatgaccat ctatacatac    480

tccaccttca aaaagtacat caatattata tcattaagga aatagtaacc ttctcttctc    540

caatatgcat gacatttttg gacaatgcaa ttgtggcact ggcacttgtt tcagtgaaga    600

aaaactttgt ggttctatgg cattcatcat ttgacaaatg caagcatctt ccttatcaat    660

cagctcctat tgaacttact agcactgact gtggaatcct taagggccca ttacatttct    720

gaagaagaaa gctaagatga aggacatgcc actccgaatt catgtgctac ttggcctagc    780

tatcactaca ctagtacaag ctgtagataa aaaagtggat tgtccacggt tatgtacgtg    840

tgaaatcagg ccttggttta cacccagatc catttatatg gaagcatcta cagtggattg    900

taatgattta ggtcttttaa ctttcccagc cagattgcca gctaacacac agattcttct    960

cctacagact aacaatattg caaaaattga atactccaca gactttccag taaaccttac   1020

tagcctggat ttatctcaaa acaatttatc ttcagtcacc aatattaatg taaaaaagat   1080

gcctcagctc ctttctgtgt acctagagga aaacaaactt actgaactgc ctgaaaaatg   1140

tctgtccgaa ctgagcaact tacaagaact ctatattaat cacaacttgc tttctacaat   1200

ttcacctgga gcctttattg gcctacataa tcttcttcga cttcatctca attcaaatag   1260

attgcagatg atcaacagta agtggtttga tgctcttcca aatctagaga ttctgatgat   1320

tggggaaaat ccaattatca gaatcaaaga catgaacttt aagcctctta tcaatcttcg   1380

cagcctggtt atagctggta taaacctcac agaaatacca gataacgcct tggttggact   1440

ggaaaactta gaaagcatct ctttttacga taacaggctt attaaagtac cccatgttgc   1500

tcttcaaaaa gttgtaaatc tcaaattttt ggatctaaat aaaaatccta ttaatagaat   1560

acgaaggggt gattttagca atatgctaca cttaaaagag ttggggataa ataatatgcc   1620

tgagctgatt tccatcgata gtcttgctgt ggataacctg ccagatttaa gaaaaataga   1680

agctactaac aaccctagat tgtcttacat tcaccccaat gcatttttca gactccccaa   1740

gctggaatca ctcatgctga acagcaatgc tctcagtgcc ctgtaccatg gtaccattga   1800

gtctctgcca aacctcaagg aaatcagcat acacagtaac cccatcaggt gtgactgtgt   1860

catccgttgg atgaacatga acaaaaccaa cattcgattc atggagccag attcactgtt   1920

ttgcgtggac ccacctgaat tccaaggtca gaatgttcgg caagtgcatt tcagggacat   1980

gatggaaatt tgtctccctc ttatagctcc tgagagcttt ccttctaatc taaatgtaga   2040

agctgggagc tatgtttcct ttcactgtag agctactgca gaaccacagc ctgaaatcta   2100

ctggataaca ccttctggtc aaaaactctt gcctaatacc ctgacagaca agttctatgt   2160

ccattctgag ggaacactag atataaatgg cgtaactccc aaagaagggg gtttatatac   2220

ttgtatagca actaacctag ttggcgctga cttgaagtct gttatgatca aagtggatgg   2280

atcttttcca caagataaca atggctcttt gaatattaaa ataagagata ttcatgccaa   2340

ttcagttttg gtgtcctgga aagcaagttc taaaattctc aaatctagtg ttaaatggac   2400

agcctttgtc aagactgaaa attctcatgc tgcgcaaagt gctcgaatac catctgatgt   2460

caaggtatat aatcttactc atctgaatcc atcaactgag tataaaattt gtattgatat   2520

tcccaccatc tatcagaaaa acagaaaaaa atgtgtaaat gtcaccacca aaggtttgca   2580

ccctgatcaa aaagagtatg aaaagaataa taccacaaca cttatggcct gtcttggagg   2640

ccttctgggg attattggtg tgatatgtct tatcagctgc ctctctccag aaatgaactg   2700

tgatggtgga cacagctatg tgaggaatta cttacagaaa ccaacctttg cattaggtga   2760

gctttatcct cctctgataa atctctggga agcaggaaaa gaaaaaagta catcactgaa   2820

agtaaaagca actgttatag gtttaccaac aaatatgtcc taaaaaccac caaggaaacc   2880

tactccaaaa atgaacaaaa aaaaaaaaag cgaaagactg cagttgtgct aaaaacaaaa   2940

caaaacaaac aaacaaacaa aaaagtaaaa aaagattact ttcgagagag aagtttaagc   3000

ttcaccaatg ctgctcctga ccaatggaaa tatgtacaac ttcagcattt taagtaactg   3060

gcttcaaggg gtactgtggc aaccaaataa aataactcca ttttctaaaa ctttcatgta   3120

acttttatgt ctggactaca gttcaagtgg acaaaaacat ttctgtattt tttttaagta   3180

aataagagta gttgaactga gcaatacctc ctcctgtgtt gtattacaca tattagccac   3240

gagtttttgc agtgaccaga taaacttgaa ttgacacgtg gtgtaataaa atggacaaat   3300

tctgtagagt agacacagtg agtatgtgga cctcttttat aaggaaaaat acattttgga   3360

ttaaaatcaa aaaaaaaaaa aaaaaaaaa                                     3389


<210>  2104
<211>  708
<212>  PRT
<213>  Homosapiens

<400>  2104

Met Lys Asp Met Pro Leu Arg Ile His Val Leu Leu Gly Leu Ala Ile 
1               5                   10                  15      


Thr Thr Leu Val Gln Ala Val Asp Lys Lys Val Asp Cys Pro Arg Leu 
            20                  25                  30          


Cys Thr Cys Glu Ile Arg Pro Trp Phe Thr Pro Arg Ser Ile Tyr Met 
        35                  40                  45              


Glu Ala Ser Thr Val Asp Cys Asn Asp Leu Gly Leu Leu Thr Phe Pro 
    50                  55                  60                  


Ala Arg Leu Pro Ala Asn Thr Gln Ile Leu Leu Leu Gln Thr Asn Asn 
65                  70                  75                  80  


Ile Ala Lys Ile Glu Tyr Ser Thr Asp Phe Pro Val Asn Leu Thr Ser 
                85                  90                  95      


Leu Asp Leu Ser Gln Asn Asn Leu Ser Ser Val Thr Asn Ile Asn Val 
            100                 105                 110         


Lys Lys Met Pro Gln Leu Leu Ser Val Tyr Leu Glu Glu Asn Lys Leu 
        115                 120                 125             


Thr Glu Leu Pro Glu Lys Cys Leu Ser Glu Leu Ser Asn Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Ile Asn His Asn Leu Leu Ser Thr Ile Ser Pro Gly Ala Phe 
145                 150                 155                 160 


Ile Gly Leu His Asn Leu Leu Arg Leu His Leu Asn Ser Asn Arg Leu 
                165                 170                 175     


Gln Met Ile Asn Ser Lys Trp Phe Asp Ala Leu Pro Asn Leu Glu Ile 
            180                 185                 190         


Leu Met Ile Gly Glu Asn Pro Ile Ile Arg Ile Lys Asp Met Asn Phe 
        195                 200                 205             


Lys Pro Leu Ile Asn Leu Arg Ser Leu Val Ile Ala Gly Ile Asn Leu 
    210                 215                 220                 


Thr Glu Ile Pro Asp Asn Ala Leu Val Gly Leu Glu Asn Leu Glu Ser 
225                 230                 235                 240 


Ile Ser Phe Tyr Asp Asn Arg Leu Ile Lys Val Pro His Val Ala Leu 
                245                 250                 255     


Gln Lys Val Val Asn Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro Ile 
            260                 265                 270         


Asn Arg Ile Arg Arg Gly Asp Phe Ser Asn Met Leu His Leu Lys Glu 
        275                 280                 285             


Leu Gly Ile Asn Asn Met Pro Glu Leu Ile Ser Ile Asp Ser Leu Ala 
    290                 295                 300                 


Val Asp Asn Leu Pro Asp Leu Arg Lys Ile Glu Ala Thr Asn Asn Pro 
305                 310                 315                 320 


Arg Leu Ser Tyr Ile His Pro Asn Ala Phe Phe Arg Leu Pro Lys Leu 
                325                 330                 335     


Glu Ser Leu Met Leu Asn Ser Asn Ala Leu Ser Ala Leu Tyr His Gly 
            340                 345                 350         


Thr Ile Glu Ser Leu Pro Asn Leu Lys Glu Ile Ser Ile His Ser Asn 
        355                 360                 365             


Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Met Asn Met Asn Lys Thr 
    370                 375                 380                 


Asn Ile Arg Phe Met Glu Pro Asp Ser Leu Phe Cys Val Asp Pro Pro 
385                 390                 395                 400 


Glu Phe Gln Gly Gln Asn Val Arg Gln Val His Phe Arg Asp Met Met 
                405                 410                 415     


Glu Ile Cys Leu Pro Leu Ile Ala Pro Glu Ser Phe Pro Ser Asn Leu 
            420                 425                 430         


Asn Val Glu Ala Gly Ser Tyr Val Ser Phe His Cys Arg Ala Thr Ala 
        435                 440                 445             


Glu Pro Gln Pro Glu Ile Tyr Trp Ile Thr Pro Ser Gly Gln Lys Leu 
    450                 455                 460                 


Leu Pro Asn Thr Leu Thr Asp Lys Phe Tyr Val His Ser Glu Gly Thr 
465                 470                 475                 480 


Leu Asp Ile Asn Gly Val Thr Pro Lys Glu Gly Gly Leu Tyr Thr Cys 
                485                 490                 495     


Ile Ala Thr Asn Leu Val Gly Ala Asp Leu Lys Ser Val Met Ile Lys 
            500                 505                 510         


Val Asp Gly Ser Phe Pro Gln Asp Asn Asn Gly Ser Leu Asn Ile Lys 
        515                 520                 525             


Ile Arg Asp Ile His Ala Asn Ser Val Leu Val Ser Trp Lys Ala Ser 
    530                 535                 540                 


Ser Lys Ile Leu Lys Ser Ser Val Lys Trp Thr Ala Phe Val Lys Thr 
545                 550                 555                 560 


Glu Asn Ser His Ala Ala Gln Ser Ala Arg Ile Pro Ser Asp Val Lys 
                565                 570                 575     


Val Tyr Asn Leu Thr His Leu Asn Pro Ser Thr Glu Tyr Lys Ile Cys 
            580                 585                 590         


Ile Asp Ile Pro Thr Ile Tyr Gln Lys Asn Arg Lys Lys Cys Val Asn 
        595                 600                 605             


Val Thr Thr Lys Gly Leu His Pro Asp Gln Lys Glu Tyr Glu Lys Asn 
    610                 615                 620                 


Asn Thr Thr Thr Leu Met Ala Cys Leu Gly Gly Leu Leu Gly Ile Ile 
625                 630                 635                 640 


Gly Val Ile Cys Leu Ile Ser Cys Leu Ser Pro Glu Met Asn Cys Asp 
                645                 650                 655     


Gly Gly His Ser Tyr Val Arg Asn Tyr Leu Gln Lys Pro Thr Phe Ala 
            660                 665                 670         


Leu Gly Glu Leu Tyr Pro Pro Leu Ile Asn Leu Trp Glu Ala Gly Lys 
        675                 680                 685             


Glu Lys Ser Thr Ser Leu Lys Val Lys Ala Thr Val Ile Gly Leu Pro 
    690                 695                 700                 


Thr Asn Met Ser 
705             


<210>  2105
<211>  4560
<212>  DNA
<213>  Homosapiens

<400>  2105
agttttcctt tcgttctgcg gccgctgcag ccagccccgc ggctccctca gacccgcggg     60

cgcagccgcc gggggtgagg cgcttgggga ccgcgggccg agcggcgggg atccccgagc    120

accatgctgg acccgtcttc cagcgaagag gagtcggacg aggggctgga agaggaaagc    180

cgcgatgtgc tggtggcagc cggcagctcg cagcgagctc ctccagcccc gactcgggaa    240

gggcagctgg acgatgagca ggagcggagg atccgcctgc agctctacgt cttcgtcgtg    300

aggtgcatcg cgtacccctt caacgccaag cagcccaccg acatggcccg gaggcagcag    360

aagcttaaca aacaacagtt gcagttactg aaagaacggt tccaggcctt cctcaatggg    420

gaaacccaaa ttgtagctga cgaagcattt tgcaacgcag ttcggagtta ttatgaggtt    480

tttctaaaga gtgaccgagt ggccagaatg gtacagagtg gagggtgttc tgctaatgac    540

ttcagagaag tatttaagaa aaacatagaa aaacgtgtgc ggagtttgcc agaaatagat    600

ggcttgagca aagagacagt gttgagctca tggatagcca aatatgatgc catttacaga    660

ggtgaagagg acttgtgcaa acagccaaat agaatggccc taagtgcagt gtctgaactt    720

attctgagca aggaacaact ctatgaaatg tttcagcaga ttctgggtat taaaaaactg    780

gaacaccagc tcctttataa tgcatgtcag ctggataacg cagatgaaca agcagcccag    840

atcagaaggg aacttgatgg ccggctgcaa ttggcagata aaatggcaaa ggaaagaaaa    900

ttccccaaat ttatagcaaa agatatggag aatatgtata tagaagagtt gcggtcttca    960

gtgaatttgc taatggccaa tttggaaagt cttccagttt cgaaaggtgg tccggaattt   1020

aaattacaaa aattaaaacg ttcacagaac tctgcatttt tggacatagg agatgagaat   1080

gagattcagc tgtcaaagtc cgacgtggta ctgtcattca ccttagagat tgtcataatg   1140

gaagtgcaag gcctgaagtc agttgctccc aatcgaattg tttactgtac aatggaagtg   1200

gaaggagaaa aacttcagac agaccaggcc gaagcctcaa ggccacaatg ggggactcaa   1260

ggagatttca ccaccaccca tcctcggcct gtggtcaaag tgaaactctt cacagaaagc   1320

actggagttc tggccctgga agataaagaa ctgggaaggg tgatattata cccaacttct   1380

aatagctcca aatcagctga attacaccga atggtagttc caaaaaatag ccaggattct   1440

gacttaaaaa tcaaactggc agtgcgaatg gataaaccag cacatatgaa gcatagtgga   1500

tatctgtatg cccttggaca gaaggtttgg aaaagatgga aaaaacgtta ctttgttcta   1560

gttcaggtta gccaatatac ctttgctatg tgcagttata gagaaaagaa gtctgaacca   1620

caagaattaa tgcagcttga aggctatact gtggattata ccgatcccca cccaggcctt   1680

cagggtggtt gtatgttctt taatgctgtt aaagaaggag atactgtaat ctttgccagt   1740

gatgatgaac aggacagaat attatgggtt caagccatgt atagggccac aggtcaatca   1800

tataaaccag ttcctgcaat tcaaacccag aaactgaatc ctaaaggagg aactctccat   1860

gcagatgctc agctttatgc agatcgtttt cagaaacatg gtatggatga gtttatttct   1920

gcaaacccct gcaagcttga tcatgccttc ctttttagaa tactccagag gcagactttg   1980

gatcacagac tgaatgattc ctattcttgc ttgggatggt ttagccctgg ccaagtcttt   2040

gtgttagatg agtactgtgc ccgttatggt gtgagaggct gtcacagaca tctctgctac   2100

cttgcagaac tgatggaaca ttcagaaaat ggtgctgtca ttgaccctac cctgctccat   2160

tacagctttg cattctgtgc ctctcatgtg cacggcaaca ggcctgatgg aattgggact   2220

gtttcagtgg aagaaaaaga aagatttgag gagataaaag agagactctc ttccctttta   2280

gaaaatcaga taagccattt cagatactgt tttccctttg gacgacctga aggtgctcta   2340

aaagctacac tttcattact tgaaagggtt ttaatgaaag atattgccac tcccatacca   2400

gcagaagagg tgaagaaagt ggtcagaaaa tgtctcgaga aagctgcctt gatcaattac   2460

actagactca cagaatatgc caaaatagaa gagaccatga accaggcatc tcctgctaga   2520

aagctggaag agattcttca tctggcagag ctctgcatag aagtcttaca gcagaatgaa   2580

gagcatcatg cagaggcatt tgcctggtgg cctgatttat tggctgaaca tgcagagaaa   2640

ttttgggctt tatttacagt ggatatggac actgcactag aggctcaacc gcaagactcc   2700

tgggatagtt ttcctctttt ccaactgctt aataatttcc tccgaaatga cacacttttg   2760

tgtaatggaa aatttcacaa acacttgcaa gaaatctttg tacccttggt tgtccgctat   2820

gtggatctca tggagtcttc catcgcccag tcaattcaca gaggttttga gcaggagaca   2880

tggcagcctg tcaacaatgg ctcagcaaca tcagaagacc ttttttggaa gcttgatgca   2940

ctgcaaatgt ttgtctttga tctgcactgg ccagaacagg aatttgccca ccacttagag   3000

caaagactta aactaatggc cagtgatatg ctagaggcct gtgtcaaaag aacaagaact   3060

gcatttgaac tcaagctaca aaaggcaagc aaaacaactg acttgcgcat tccagcttcc   3120

gtttgcacta tgtttaatgt attagtcgat gccaaaaagc aaagcaccaa actctgtgcc   3180

ctggatggag gacaagagtt tggtagtcaa tggcaacagt accattcaaa aatagatgat   3240

ctgatcgaca acagtgtaaa agaaatcatt tcactgttag tttcaaagtt tgtttcagtg   3300

ttggaaggcg tgttgtctaa gctgtcaagg tatgatgaag gcactttctt ttcatccatt   3360

ctgtcattca ctgtgaaagc agctgcaaaa tatgttgatg ttccaaaacc aggaatggat   3420

ctggcagaca cctatattat gtttgttcgg caaaaccaag atattcttcg agaaaaggtc   3480

aatgaggaaa tgtatataga aaagttattt gatcaatggt acagcagttc catgaaagtc   3540

atttgcgtgt ggttgactga tagattagac ctccaactcc atatttacca gctgaagacg   3600

ctcatcaaga ttgtgaagaa aacctacagg gactttcgat tgcagggtgt gttggaagga   3660

acactgaaca gtaagactta tgatactgtg cacagacgtt taacagtaga ggaggccaca   3720

gcctctgttt cagaaggagg aggacttcag ggcattacta tgaaagacag tgacgaagaa   3780

gaagaaggct gatatcacac agctttgcag aaggaaggaa gaccttgatc gacattgttt   3840

tttatttttt taaccttgtc cttgtaatta cattcattgt ttgttttggc caaataaaaa   3900

tgcttgtatt tctttaaaaa gtaagcctga atgtagagta aaaggggaaa tgccaagatt   3960

ttggggtttt tttgtttcct ttttttgttt gtttgtttgt ttgttttttt ggagaagagc   4020

atcctctttt gtgtagtttg acctaaaaat gaaccttggc tctgcttgtg atcagaacat   4080

gaactttttt ttttaaagaa gatttgagca tttttctgta atcacatcaa aatgatgttt   4140

tctgtgtaaa gcgagataca tatttctcat aatgcagcat tgtgagaagt cagttcggac   4200

cactgcacca acactgtcgt atccttgtta aaatggtgtg taccttacaa attataattt   4260

atgtgccagg ttcgttttgt acttaatttg ctattattgt gatgtgtata aaatctttaa   4320

tcttggttct tagtactttg aattggtcta caggtatatt cctgggatga aaggattgcc   4380

aaacccaaat atagactaga ttatccaatg ggtttgtgtc tttgttccat tctcaacatt   4440

tcttctttca actataagta atccccaggt gtggggtagc aagtgtgctt ccgtcaagat   4500

accatattct cctgctccag tataacagct tgcaggcaat aaaaatctat ttgctcataa   4560


<210>  2106
<211>  1222
<212>  PRT
<213>  Homosapiens

<400>  2106

Met Leu Asp Pro Ser Ser Ser Glu Glu Glu Ser Asp Glu Gly Leu Glu 
1               5                   10                  15      


Glu Glu Ser Arg Asp Val Leu Val Ala Ala Gly Ser Ser Gln Arg Ala 
            20                  25                  30          


Pro Pro Ala Pro Thr Arg Glu Gly Gln Leu Asp Asp Glu Gln Glu Arg 
        35                  40                  45              


Arg Ile Arg Leu Gln Leu Tyr Val Phe Val Val Arg Cys Ile Ala Tyr 
    50                  55                  60                  


Pro Phe Asn Ala Lys Gln Pro Thr Asp Met Ala Arg Arg Gln Gln Lys 
65                  70                  75                  80  


Leu Asn Lys Gln Gln Leu Gln Leu Leu Lys Glu Arg Phe Gln Ala Phe 
                85                  90                  95      


Leu Asn Gly Glu Thr Gln Ile Val Ala Asp Glu Ala Phe Cys Asn Ala 
            100                 105                 110         


Val Arg Ser Tyr Tyr Glu Val Phe Leu Lys Ser Asp Arg Val Ala Arg 
        115                 120                 125             


Met Val Gln Ser Gly Gly Cys Ser Ala Asn Asp Phe Arg Glu Val Phe 
    130                 135                 140                 


Lys Lys Asn Ile Glu Lys Arg Val Arg Ser Leu Pro Glu Ile Asp Gly 
145                 150                 155                 160 


Leu Ser Lys Glu Thr Val Leu Ser Ser Trp Ile Ala Lys Tyr Asp Ala 
                165                 170                 175     


Ile Tyr Arg Gly Glu Glu Asp Leu Cys Lys Gln Pro Asn Arg Met Ala 
            180                 185                 190         


Leu Ser Ala Val Ser Glu Leu Ile Leu Ser Lys Glu Gln Leu Tyr Glu 
        195                 200                 205             


Met Phe Gln Gln Ile Leu Gly Ile Lys Lys Leu Glu His Gln Leu Leu 
    210                 215                 220                 


Tyr Asn Ala Cys Gln Leu Asp Asn Ala Asp Glu Gln Ala Ala Gln Ile 
225                 230                 235                 240 


Arg Arg Glu Leu Asp Gly Arg Leu Gln Leu Ala Asp Lys Met Ala Lys 
                245                 250                 255     


Glu Arg Lys Phe Pro Lys Phe Ile Ala Lys Asp Met Glu Asn Met Tyr 
            260                 265                 270         


Ile Glu Glu Leu Arg Ser Ser Val Asn Leu Leu Met Ala Asn Leu Glu 
        275                 280                 285             


Ser Leu Pro Val Ser Lys Gly Gly Pro Glu Phe Lys Leu Gln Lys Leu 
    290                 295                 300                 


Lys Arg Ser Gln Asn Ser Ala Phe Leu Asp Ile Gly Asp Glu Asn Glu 
305                 310                 315                 320 


Ile Gln Leu Ser Lys Ser Asp Val Val Leu Ser Phe Thr Leu Glu Ile 
                325                 330                 335     


Val Ile Met Glu Val Gln Gly Leu Lys Ser Val Ala Pro Asn Arg Ile 
            340                 345                 350         


Val Tyr Cys Thr Met Glu Val Glu Gly Glu Lys Leu Gln Thr Asp Gln 
        355                 360                 365             


Ala Glu Ala Ser Arg Pro Gln Trp Gly Thr Gln Gly Asp Phe Thr Thr 
    370                 375                 380                 


Thr His Pro Arg Pro Val Val Lys Val Lys Leu Phe Thr Glu Ser Thr 
385                 390                 395                 400 


Gly Val Leu Ala Leu Glu Asp Lys Glu Leu Gly Arg Val Ile Leu Tyr 
                405                 410                 415     


Pro Thr Ser Asn Ser Ser Lys Ser Ala Glu Leu His Arg Met Val Val 
            420                 425                 430         


Pro Lys Asn Ser Gln Asp Ser Asp Leu Lys Ile Lys Leu Ala Val Arg 
        435                 440                 445             


Met Asp Lys Pro Ala His Met Lys His Ser Gly Tyr Leu Tyr Ala Leu 
    450                 455                 460                 


Gly Gln Lys Val Trp Lys Arg Trp Lys Lys Arg Tyr Phe Val Leu Val 
465                 470                 475                 480 


Gln Val Ser Gln Tyr Thr Phe Ala Met Cys Ser Tyr Arg Glu Lys Lys 
                485                 490                 495     


Ser Glu Pro Gln Glu Leu Met Gln Leu Glu Gly Tyr Thr Val Asp Tyr 
            500                 505                 510         


Thr Asp Pro His Pro Gly Leu Gln Gly Gly Cys Met Phe Phe Asn Ala 
        515                 520                 525             


Val Lys Glu Gly Asp Thr Val Ile Phe Ala Ser Asp Asp Glu Gln Asp 
    530                 535                 540                 


Arg Ile Leu Trp Val Gln Ala Met Tyr Arg Ala Thr Gly Gln Ser Tyr 
545                 550                 555                 560 


Lys Pro Val Pro Ala Ile Gln Thr Gln Lys Leu Asn Pro Lys Gly Gly 
                565                 570                 575     


Thr Leu His Ala Asp Ala Gln Leu Tyr Ala Asp Arg Phe Gln Lys His 
            580                 585                 590         


Gly Met Asp Glu Phe Ile Ser Ala Asn Pro Cys Lys Leu Asp His Ala 
        595                 600                 605             


Phe Leu Phe Arg Ile Leu Gln Arg Gln Thr Leu Asp His Arg Leu Asn 
    610                 615                 620                 


Asp Ser Tyr Ser Cys Leu Gly Trp Phe Ser Pro Gly Gln Val Phe Val 
625                 630                 635                 640 


Leu Asp Glu Tyr Cys Ala Arg Tyr Gly Val Arg Gly Cys His Arg His 
                645                 650                 655     


Leu Cys Tyr Leu Ala Glu Leu Met Glu His Ser Glu Asn Gly Ala Val 
            660                 665                 670         


Ile Asp Pro Thr Leu Leu His Tyr Ser Phe Ala Phe Cys Ala Ser His 
        675                 680                 685             


Val His Gly Asn Arg Pro Asp Gly Ile Gly Thr Val Ser Val Glu Glu 
    690                 695                 700                 


Lys Glu Arg Phe Glu Glu Ile Lys Glu Arg Leu Ser Ser Leu Leu Glu 
705                 710                 715                 720 


Asn Gln Ile Ser His Phe Arg Tyr Cys Phe Pro Phe Gly Arg Pro Glu 
                725                 730                 735     


Gly Ala Leu Lys Ala Thr Leu Ser Leu Leu Glu Arg Val Leu Met Lys 
            740                 745                 750         


Asp Ile Ala Thr Pro Ile Pro Ala Glu Glu Val Lys Lys Val Val Arg 
        755                 760                 765             


Lys Cys Leu Glu Lys Ala Ala Leu Ile Asn Tyr Thr Arg Leu Thr Glu 
    770                 775                 780                 


Tyr Ala Lys Ile Glu Glu Thr Met Asn Gln Ala Ser Pro Ala Arg Lys 
785                 790                 795                 800 


Leu Glu Glu Ile Leu His Leu Ala Glu Leu Cys Ile Glu Val Leu Gln 
                805                 810                 815     


Gln Asn Glu Glu His His Ala Glu Ala Phe Ala Trp Trp Pro Asp Leu 
            820                 825                 830         


Leu Ala Glu His Ala Glu Lys Phe Trp Ala Leu Phe Thr Val Asp Met 
        835                 840                 845             


Asp Thr Ala Leu Glu Ala Gln Pro Gln Asp Ser Trp Asp Ser Phe Pro 
    850                 855                 860                 


Leu Phe Gln Leu Leu Asn Asn Phe Leu Arg Asn Asp Thr Leu Leu Cys 
865                 870                 875                 880 


Asn Gly Lys Phe His Lys His Leu Gln Glu Ile Phe Val Pro Leu Val 
                885                 890                 895     


Val Arg Tyr Val Asp Leu Met Glu Ser Ser Ile Ala Gln Ser Ile His 
            900                 905                 910         


Arg Gly Phe Glu Gln Glu Thr Trp Gln Pro Val Asn Asn Gly Ser Ala 
        915                 920                 925             


Thr Ser Glu Asp Leu Phe Trp Lys Leu Asp Ala Leu Gln Met Phe Val 
    930                 935                 940                 


Phe Asp Leu His Trp Pro Glu Gln Glu Phe Ala His His Leu Glu Gln 
945                 950                 955                 960 


Arg Leu Lys Leu Met Ala Ser Asp Met Leu Glu Ala Cys Val Lys Arg 
                965                 970                 975     


Thr Arg Thr Ala Phe Glu Leu Lys Leu Gln Lys Ala Ser Lys Thr Thr 
            980                 985                 990         


Asp Leu Arg Ile Pro Ala Ser Val  Cys Thr Met Phe Asn  Val Leu Val 
        995                 1000                 1005             


Asp Ala  Lys Lys Gln Ser Thr  Lys Leu Cys Ala Leu  Asp Gly Gly 
    1010                 1015                 1020             


Gln Glu  Phe Gly Ser Gln Trp  Gln Gln Tyr His Ser  Lys Ile Asp 
    1025                 1030                 1035             


Asp Leu  Ile Asp Asn Ser Val  Lys Glu Ile Ile Ser  Leu Leu Val 
    1040                 1045                 1050             


Ser Lys  Phe Val Ser Val Leu  Glu Gly Val Leu Ser  Lys Leu Ser 
    1055                 1060                 1065             


Arg Tyr  Asp Glu Gly Thr Phe  Phe Ser Ser Ile Leu  Ser Phe Thr 
    1070                 1075                 1080             


Val Lys  Ala Ala Ala Lys Tyr  Val Asp Val Pro Lys  Pro Gly Met 
    1085                 1090                 1095             


Asp Leu  Ala Asp Thr Tyr Ile  Met Phe Val Arg Gln  Asn Gln Asp 
    1100                 1105                 1110             


Ile Leu  Arg Glu Lys Val Asn  Glu Glu Met Tyr Ile  Glu Lys Leu 
    1115                 1120                 1125             


Phe Asp  Gln Trp Tyr Ser Ser  Ser Met Lys Val Ile  Cys Val Trp 
    1130                 1135                 1140             


Leu Thr  Asp Arg Leu Asp Leu  Gln Leu His Ile Tyr  Gln Leu Lys 
    1145                 1150                 1155             


Thr Leu  Ile Lys Ile Val Lys  Lys Thr Tyr Arg Asp  Phe Arg Leu 
    1160                 1165                 1170             


Gln Gly  Val Leu Glu Gly Thr  Leu Asn Ser Lys Thr  Tyr Asp Thr 
    1175                 1180                 1185             


Val His  Arg Arg Leu Thr Val  Glu Glu Ala Thr Ala  Ser Val Ser 
    1190                 1195                 1200             


Glu Gly  Gly Gly Leu Gln Gly  Ile Thr Met Lys Asp  Ser Asp Glu 
    1205                 1210                 1215             


Glu Glu  Glu Gly 
    1220         


<210>  2107
<211>  4683
<212>  DNA
<213>  Homosapiens

<400>  2107
agttttcctt tcgttctgcg gccgctgcag ccagccccgc ggctccctca gacccgcggg     60

cgcagccgcc gggggtgagg cgcttgggga ccgcgggccg agcggcgggg atccccgagc    120

accatgctgg acccgtcttc cagcgaagag gagtcggacg aggggctgga agaggaaagc    180

cgcgatgtgc tggtggcagc cggcagctcg cagcgagctc ctccagcccc gactcgggaa    240

gggcagctgg acgatgagca ggagcggagg atccgcctgc agctctacgt cttcgtcgtg    300

aggtgcatcg cgtacccctt caacgccaag cagcccaccg acatggcccg gaggcagcag    360

aagcttaaca aacaacagtt gcagttactg aaagaacggt tccaggcctt cctcaatggg    420

gaaacccaaa ttgtagctga cgaagcattt tgcaacgcag ttcggagtta ttatgaggtt    480

tttctaaaga gtgaccgagt ggccagaatg gtacagagtg gagggtgttc tgctaatgac    540

ttcagagaag tatttaagaa aaacatagaa aaacgtgtgc ggagtttgcc agaaatagat    600

ggcttgagca aagagacagt gttgagctca tggatagcca aatatgatgc catttacaga    660

ggtgaagagg acttgtgcaa acagccaaat agaatggccc taagtgcagt gtctgaactt    720

attctgagca aggaacaact ctatgaaatg tttcagcaga ttctgggtat taaaaaactg    780

gaacaccagc tcctttataa tgcatgtcag ctggataacg cagatgaaca agcagcccag    840

atcagaaggg aacttgatgg ccggctgcaa ttggcagata aaatggcaaa ggaaagaaaa    900

ttccccaaat ttatagcaaa agatatggag aatatgtata tagaagagtt gcggtcttca    960

gtgaatttgc taatggccaa tttggaaagt cttccagttt cgaaaggtgg tccggaattt   1020

aaattacaaa aattaaaacg ttcacagaac tctgcatttt tggacatagg agatgagaat   1080

gagattcagc tgtcaaagtc cgacgtggta ctgtcattca ccttagagat tgtcataatg   1140

gaagtgcaag gcctgaagtc agttgctccc aatcgaattg tttactgtac aatggaagtg   1200

gaaggagaaa aacttcagac agaccaggcc gaagcctcaa ggccacaatg ggggactcaa   1260

ggagatttca ccaccaccca tcctcggcct gtggtcaaag tgaaactctt cacagaaagc   1320

actggagttc tggccctgga agataaagaa ctgggaaggg tgatattata cccaacttct   1380

aatagctcca aatcagctga attacaccga atggtagttc caaaaaatag ccaggattct   1440

gacttaaaaa tcaaactggc agtgcgaatg gataaaccag cacatatgaa gcatagtgga   1500

tatctgtatg cccttggaca gaaggtttgg aaaagatgga aaaaacgtta ctttgttcta   1560

gttcaggtta gccaatatac ctttgctatg tgcagttata gagaaaagaa gtctgaacca   1620

caagaattaa tgcagcttga aggctatact gtggattata ccgatcccca cccaggcctt   1680

cagggtggtt gtatgttctt taatgctgtt aaagaaggag atactgtaat ctttgccagt   1740

gatgatgaac aggacagaat attatgggtt caagccatgt atagggccac aggtcaatca   1800

tataaaccag ttcctgcaat tcaaacccag aaactgaatc ctaaaggagg aactctccat   1860

gcagatgctc agctttctgg taaagatgca gatcgttttc agaaacatgg tatggatgag   1920

tttatttctg caaacccctg caagcttgat catgccttcc tttttagaat actccagagg   1980

cagactttgg atcacagact gaatgattcc tattcttgct tgggatggtt tagccctggc   2040

caagtctttg tgttagatga gtactgtgcc cgttatggtg tgagaggctg tcacagacat   2100

ctctgctacc ttgcagaact gatggaacat tcagaaaatg gtgctgtcat tgaccctacc   2160

ctgctccatt acagctttgc attctgtgcc tctcatgtgc acggcaacag gcctgatgga   2220

attgggactg tttcagtgga agaaaaagaa agatttgagg agataaaaga gagactctct   2280

tcccttttag aaaatcagat aagccatttc agatactgtt ttccctttgg acgacctgaa   2340

ggtgctctaa aagctacact ttcattactt gaaagggttt taatgaaaga tattgccact   2400

cccataccag cagaagaggt gaagaaagtg gtcagaaaat gtctcgagaa agctgccttg   2460

atcaattaca ctagactcac agaatatgcc aaaatagaag agaccatgaa ccaggcatct   2520

cctgctagaa agctggaaga gattcttcat ctggcagagc tctgcataga agtcttacag   2580

cagaatgaag agcatcatgc agagggaaga gaggcatttg cctggtggcc tgatttattg   2640

gctgaacatg cagagaaatt ttgggcttta tttacagtgg atatggacac tgcactagag   2700

gctcaaccgc aagactcctg ggatagtttt cctcttttcc aactgcttaa taatttcctc   2760

cgaaatgaca cacttttgtg taatggaaaa tttcacaaac acttgcaaga aatctttgta   2820

cccttggttg tccgctatgt ggatctcatg gagtcttcca tcgcccagtc aattcacaga   2880

ggttttgagc aggagacatg gcagcctgtc aagaatatcg ccaacagtct tcccaatgta   2940

gctcttccaa aagttccaag tctgcctctt aatcttccac agattcctaa catttctact   3000

gcttcgtgga tgccttcttt atatgagtcc accaatggct cagcaacatc agaagacctt   3060

ttttggaagc ttgatgcact gcaaatgttt gtctttgatc tgcactggcc agaacaggaa   3120

tttgcccacc acttagagca aagacttaaa ctaatggcca gtgatatgct agaggcctgt   3180

gtcaaaagaa caagaactgc atttgaactc aagctacaaa aggcaagcaa aacaactgac   3240

ttgcgcattc cagcttccgt ttgcactatg tttaatgtat tagtcgatgc caaaaagcaa   3300

agcaccaaac tctgtgccct ggatggagga caagagcaac agtaccattc aaaaatagat   3360

gatctgatcg acaacagtgt aaaagaaatc atttcactgt tagtttcaaa gtttgtttca   3420

gtgttggaag gcgtgttgtc taagctgtca aggtatgatg aaggcacttt cttttcatcc   3480

attctgtcat tcactgtgaa agcagctgca aaatatgttg atgttccaaa accaggaatg   3540

gatctggcag acacctatat tatgtttgtt cggcaaaacc aagatattct tcgagaaaag   3600

gtcaatgagg aaatgtatat agaaaagtta tttgatcaat ggtacagcag ttccatgaaa   3660

gtcatttgcg tgtggttgac tgatagatta gacctccaac tccatattta ccagctgaag   3720

acgctcatca agattgtgaa gaaaacctac agggactttc gattgcaggg tgtgttggaa   3780

ggaacactga acagtaagac ttatgatact gtgcacagac gtttaacagt agaggaggcc   3840

acagcctctg tttcagaagg aggaggactt cagggcatta ctatgaaaga cagtgacgaa   3900

gaagaagaag gctgatatca cacagctttg cagaaggaag gaagaccttg atcgacattg   3960

ttttttattt ttttaacctt gtccttgtaa ttacattcat tgtttgtttt ggccaaataa   4020

aaatgcttgt atttctttaa aaagtaagcc tgaatgtaga gtaaaagggg aaatgccaag   4080

attttggggt ttttttgttt cctttttttg tttgtttgtt tgtttgtttt tttggagaag   4140

agcatcctct tttgtgtagt ttgacctaaa aatgaacctt ggctctgctt gtgatcagaa   4200

catgaacttt tttttttaaa gaagatttga gcatttttct gtaatcacat caaaatgatg   4260

ttttctgtgt aaagcgagat acatatttct cataatgcag cattgtgaga agtcagttcg   4320

gaccactgca ccaacactgt cgtatccttg ttaaaatggt gtgtacctta caaattataa   4380

tttatgtgcc aggttcgttt tgtacttaat ttgctattat tgtgatgtgt ataaaatctt   4440

taatcttggt tcttagtact ttgaattggt ctacaggtat attcctggga tgaaaggatt   4500

gccaaaccca aatatagact agattatcca atgggtttgt gtctttgttc cattctcaac   4560

atttcttctt tcaactataa gtaatcccca ggtgtggggt agcaagtgtg cttccgtcaa   4620

gataccatat tctcctgctc cagtataaca gcttgcaggc aataaaaatc tatttgctca   4680

taa                                                                 4683


<210>  2108
<211>  1263
<212>  PRT
<213>  Homosapiens

<400>  2108

Met Leu Asp Pro Ser Ser Ser Glu Glu Glu Ser Asp Glu Gly Leu Glu 
1               5                   10                  15      


Glu Glu Ser Arg Asp Val Leu Val Ala Ala Gly Ser Ser Gln Arg Ala 
            20                  25                  30          


Pro Pro Ala Pro Thr Arg Glu Gly Gln Leu Asp Asp Glu Gln Glu Arg 
        35                  40                  45              


Arg Ile Arg Leu Gln Leu Tyr Val Phe Val Val Arg Cys Ile Ala Tyr 
    50                  55                  60                  


Pro Phe Asn Ala Lys Gln Pro Thr Asp Met Ala Arg Arg Gln Gln Lys 
65                  70                  75                  80  


Leu Asn Lys Gln Gln Leu Gln Leu Leu Lys Glu Arg Phe Gln Ala Phe 
                85                  90                  95      


Leu Asn Gly Glu Thr Gln Ile Val Ala Asp Glu Ala Phe Cys Asn Ala 
            100                 105                 110         


Val Arg Ser Tyr Tyr Glu Val Phe Leu Lys Ser Asp Arg Val Ala Arg 
        115                 120                 125             


Met Val Gln Ser Gly Gly Cys Ser Ala Asn Asp Phe Arg Glu Val Phe 
    130                 135                 140                 


Lys Lys Asn Ile Glu Lys Arg Val Arg Ser Leu Pro Glu Ile Asp Gly 
145                 150                 155                 160 


Leu Ser Lys Glu Thr Val Leu Ser Ser Trp Ile Ala Lys Tyr Asp Ala 
                165                 170                 175     


Ile Tyr Arg Gly Glu Glu Asp Leu Cys Lys Gln Pro Asn Arg Met Ala 
            180                 185                 190         


Leu Ser Ala Val Ser Glu Leu Ile Leu Ser Lys Glu Gln Leu Tyr Glu 
        195                 200                 205             


Met Phe Gln Gln Ile Leu Gly Ile Lys Lys Leu Glu His Gln Leu Leu 
    210                 215                 220                 


Tyr Asn Ala Cys Gln Leu Asp Asn Ala Asp Glu Gln Ala Ala Gln Ile 
225                 230                 235                 240 


Arg Arg Glu Leu Asp Gly Arg Leu Gln Leu Ala Asp Lys Met Ala Lys 
                245                 250                 255     


Glu Arg Lys Phe Pro Lys Phe Ile Ala Lys Asp Met Glu Asn Met Tyr 
            260                 265                 270         


Ile Glu Glu Leu Arg Ser Ser Val Asn Leu Leu Met Ala Asn Leu Glu 
        275                 280                 285             


Ser Leu Pro Val Ser Lys Gly Gly Pro Glu Phe Lys Leu Gln Lys Leu 
    290                 295                 300                 


Lys Arg Ser Gln Asn Ser Ala Phe Leu Asp Ile Gly Asp Glu Asn Glu 
305                 310                 315                 320 


Ile Gln Leu Ser Lys Ser Asp Val Val Leu Ser Phe Thr Leu Glu Ile 
                325                 330                 335     


Val Ile Met Glu Val Gln Gly Leu Lys Ser Val Ala Pro Asn Arg Ile 
            340                 345                 350         


Val Tyr Cys Thr Met Glu Val Glu Gly Glu Lys Leu Gln Thr Asp Gln 
        355                 360                 365             


Ala Glu Ala Ser Arg Pro Gln Trp Gly Thr Gln Gly Asp Phe Thr Thr 
    370                 375                 380                 


Thr His Pro Arg Pro Val Val Lys Val Lys Leu Phe Thr Glu Ser Thr 
385                 390                 395                 400 


Gly Val Leu Ala Leu Glu Asp Lys Glu Leu Gly Arg Val Ile Leu Tyr 
                405                 410                 415     


Pro Thr Ser Asn Ser Ser Lys Ser Ala Glu Leu His Arg Met Val Val 
            420                 425                 430         


Pro Lys Asn Ser Gln Asp Ser Asp Leu Lys Ile Lys Leu Ala Val Arg 
        435                 440                 445             


Met Asp Lys Pro Ala His Met Lys His Ser Gly Tyr Leu Tyr Ala Leu 
    450                 455                 460                 


Gly Gln Lys Val Trp Lys Arg Trp Lys Lys Arg Tyr Phe Val Leu Val 
465                 470                 475                 480 


Gln Val Ser Gln Tyr Thr Phe Ala Met Cys Ser Tyr Arg Glu Lys Lys 
                485                 490                 495     


Ser Glu Pro Gln Glu Leu Met Gln Leu Glu Gly Tyr Thr Val Asp Tyr 
            500                 505                 510         


Thr Asp Pro His Pro Gly Leu Gln Gly Gly Cys Met Phe Phe Asn Ala 
        515                 520                 525             


Val Lys Glu Gly Asp Thr Val Ile Phe Ala Ser Asp Asp Glu Gln Asp 
    530                 535                 540                 


Arg Ile Leu Trp Val Gln Ala Met Tyr Arg Ala Thr Gly Gln Ser Tyr 
545                 550                 555                 560 


Lys Pro Val Pro Ala Ile Gln Thr Gln Lys Leu Asn Pro Lys Gly Gly 
                565                 570                 575     


Thr Leu His Ala Asp Ala Gln Leu Ser Gly Lys Asp Ala Asp Arg Phe 
            580                 585                 590         


Gln Lys His Gly Met Asp Glu Phe Ile Ser Ala Asn Pro Cys Lys Leu 
        595                 600                 605             


Asp His Ala Phe Leu Phe Arg Ile Leu Gln Arg Gln Thr Leu Asp His 
    610                 615                 620                 


Arg Leu Asn Asp Ser Tyr Ser Cys Leu Gly Trp Phe Ser Pro Gly Gln 
625                 630                 635                 640 


Val Phe Val Leu Asp Glu Tyr Cys Ala Arg Tyr Gly Val Arg Gly Cys 
                645                 650                 655     


His Arg His Leu Cys Tyr Leu Ala Glu Leu Met Glu His Ser Glu Asn 
            660                 665                 670         


Gly Ala Val Ile Asp Pro Thr Leu Leu His Tyr Ser Phe Ala Phe Cys 
        675                 680                 685             


Ala Ser His Val His Gly Asn Arg Pro Asp Gly Ile Gly Thr Val Ser 
    690                 695                 700                 


Val Glu Glu Lys Glu Arg Phe Glu Glu Ile Lys Glu Arg Leu Ser Ser 
705                 710                 715                 720 


Leu Leu Glu Asn Gln Ile Ser His Phe Arg Tyr Cys Phe Pro Phe Gly 
                725                 730                 735     


Arg Pro Glu Gly Ala Leu Lys Ala Thr Leu Ser Leu Leu Glu Arg Val 
            740                 745                 750         


Leu Met Lys Asp Ile Ala Thr Pro Ile Pro Ala Glu Glu Val Lys Lys 
        755                 760                 765             


Val Val Arg Lys Cys Leu Glu Lys Ala Ala Leu Ile Asn Tyr Thr Arg 
    770                 775                 780                 


Leu Thr Glu Tyr Ala Lys Ile Glu Glu Thr Met Asn Gln Ala Ser Pro 
785                 790                 795                 800 


Ala Arg Lys Leu Glu Glu Ile Leu His Leu Ala Glu Leu Cys Ile Glu 
                805                 810                 815     


Val Leu Gln Gln Asn Glu Glu His His Ala Glu Gly Arg Glu Ala Phe 
            820                 825                 830         


Ala Trp Trp Pro Asp Leu Leu Ala Glu His Ala Glu Lys Phe Trp Ala 
        835                 840                 845             


Leu Phe Thr Val Asp Met Asp Thr Ala Leu Glu Ala Gln Pro Gln Asp 
    850                 855                 860                 


Ser Trp Asp Ser Phe Pro Leu Phe Gln Leu Leu Asn Asn Phe Leu Arg 
865                 870                 875                 880 


Asn Asp Thr Leu Leu Cys Asn Gly Lys Phe His Lys His Leu Gln Glu 
                885                 890                 895     


Ile Phe Val Pro Leu Val Val Arg Tyr Val Asp Leu Met Glu Ser Ser 
            900                 905                 910         


Ile Ala Gln Ser Ile His Arg Gly Phe Glu Gln Glu Thr Trp Gln Pro 
        915                 920                 925             


Val Lys Asn Ile Ala Asn Ser Leu Pro Asn Val Ala Leu Pro Lys Val 
    930                 935                 940                 


Pro Ser Leu Pro Leu Asn Leu Pro Gln Ile Pro Asn Ile Ser Thr Ala 
945                 950                 955                 960 


Ser Trp Met Pro Ser Leu Tyr Glu Ser Thr Asn Gly Ser Ala Thr Ser 
                965                 970                 975     


Glu Asp Leu Phe Trp Lys Leu Asp Ala Leu Gln Met Phe Val Phe Asp 
            980                 985                 990         


Leu His Trp Pro Glu Gln Glu Phe  Ala His His Leu Glu  Gln Arg Leu 
        995                 1000                 1005             


Lys Leu  Met Ala Ser Asp Met  Leu Glu Ala Cys Val  Lys Arg Thr 
    1010                 1015                 1020             


Arg Thr  Ala Phe Glu Leu Lys  Leu Gln Lys Ala Ser  Lys Thr Thr 
    1025                 1030                 1035             


Asp Leu  Arg Ile Pro Ala Ser  Val Cys Thr Met Phe  Asn Val Leu 
    1040                 1045                 1050             


Val Asp  Ala Lys Lys Gln Ser  Thr Lys Leu Cys Ala  Leu Asp Gly 
    1055                 1060                 1065             


Gly Gln  Glu Gln Gln Tyr His  Ser Lys Ile Asp Asp  Leu Ile Asp 
    1070                 1075                 1080             


Asn Ser  Val Lys Glu Ile Ile  Ser Leu Leu Val Ser  Lys Phe Val 
    1085                 1090                 1095             


Ser Val  Leu Glu Gly Val Leu  Ser Lys Leu Ser Arg  Tyr Asp Glu 
    1100                 1105                 1110             


Gly Thr  Phe Phe Ser Ser Ile  Leu Ser Phe Thr Val  Lys Ala Ala 
    1115                 1120                 1125             


Ala Lys  Tyr Val Asp Val Pro  Lys Pro Gly Met Asp  Leu Ala Asp 
    1130                 1135                 1140             


Thr Tyr  Ile Met Phe Val Arg  Gln Asn Gln Asp Ile  Leu Arg Glu 
    1145                 1150                 1155             


Lys Val  Asn Glu Glu Met Tyr  Ile Glu Lys Leu Phe  Asp Gln Trp 
    1160                 1165                 1170             


Tyr Ser  Ser Ser Met Lys Val  Ile Cys Val Trp Leu  Thr Asp Arg 
    1175                 1180                 1185             


Leu Asp  Leu Gln Leu His Ile  Tyr Gln Leu Lys Thr  Leu Ile Lys 
    1190                 1195                 1200             


Ile Val  Lys Lys Thr Tyr Arg  Asp Phe Arg Leu Gln  Gly Val Leu 
    1205                 1210                 1215             


Glu Gly  Thr Leu Asn Ser Lys  Thr Tyr Asp Thr Val  His Arg Arg 
    1220                 1225                 1230             


Leu Thr  Val Glu Glu Ala Thr  Ala Ser Val Ser Glu  Gly Gly Gly 
    1235                 1240                 1245             


Leu Gln  Gly Ile Thr Met Lys  Asp Ser Asp Glu Glu  Glu Glu Gly 
    1250                 1255                 1260             


<210>  2109
<211>  1446
<212>  DNA
<213>  Homosapiens

<400>  2109
gcagtatcta gagttaacag taggggattt atttttcaat ctaaagtttt tcacctctct     60

ctagtaagac atctgaaact cataagccat ctttaagaat ttcttacaaa aacatgctgg    120

aagacagtgg atcttgtttg tatcctgaag atttttttct cttcgttatt ttaaattaat    180

tgtcaacaga tgtgcaactg ttaggttggt tcttaagtca ctcggagaag agagagatgc    240

atctactcaa ggttggcact tggagaaaca acactgcctc ttcctggctt atgaagttca    300

gtgttctttg gcttgttagt cagaactgtt gcagagcaag tgttgtttgg atggcttata    360

tgaacatatc atttcatgtt gggaatcatg tgttgtcaga gttgggagag actggagtct    420

ttggaagaag ctccactttg aagagagtgg caggagttat agtgccacca gagggaaaaa    480

tccaaaatgc atgtaatccc aataccattt tcagccgatc aaagtactca gagacctggc    540

ttgcacttat tgaacgggga ggttgtacct tcacacagaa aattaaagtg gcaactgaga    600

agggagccag tggagtgatc atctataacg ttccaggtac tggcaaccag gtgttcccca    660

tgtttcatca ggcatttgaa gatgtcgttg tggttatgat tggtaactta aaaggcacgg    720

aaattttcca tttaattaag aagggagttc tcattacagc cgtggttgag gtggggagaa    780

agcacatcat ctggatgaat cactatttgg tctcttttgt gattgtcaca actgctacct    840

tagcatattt catcttttat cacattcata gactttgttt agcaaggatt cagaaccgga    900

gatggcagcg attaacaaca gatcttcaga acacatttgg acaactccaa cttcgagtag    960

taaaagaggg ggatgaagaa ataaatccaa atggggatag ctgcgtaatt tgctttgaac   1020

gctataagcc taatgacata gttcgtattc tgacttgtaa acattttttc cacaagaatt   1080

gcattgaccc ctggatttta ccccatggga catgccccat ttgcaaatgt gatattctta   1140

aagttttggg gattcaagtg gttgttgaaa atggaacaga acctttgcaa gttctaatgt   1200

caaatgaact gcctgaaacc ttatcaccta gtgaagagga gacaaataat gaagtttctc   1260

ctgcaggaac ctcagataaa gtaatccatg tggaggagaa ccctacttct cagaataatg   1320

acatccagcc tcattcagta gtggaagatg ttcatccttc accttgatgg catgactttt   1380

gaggaagtgt attaaacctg tatgtgaaat caggtcctaa tactgacaag cagtttgtct   1440

gttaaa                                                              1446


<210>  2110
<211>  376
<212>  PRT
<213>  Homosapiens

<400>  2110

Met His Leu Leu Lys Val Gly Thr Trp Arg Asn Asn Thr Ala Ser Ser 
1               5                   10                  15      


Trp Leu Met Lys Phe Ser Val Leu Trp Leu Val Ser Gln Asn Cys Cys 
            20                  25                  30          


Arg Ala Ser Val Val Trp Met Ala Tyr Met Asn Ile Ser Phe His Val 
        35                  40                  45              


Gly Asn His Val Leu Ser Glu Leu Gly Glu Thr Gly Val Phe Gly Arg 
    50                  55                  60                  


Ser Ser Thr Leu Lys Arg Val Ala Gly Val Ile Val Pro Pro Glu Gly 
65                  70                  75                  80  


Lys Ile Gln Asn Ala Cys Asn Pro Asn Thr Ile Phe Ser Arg Ser Lys 
                85                  90                  95      


Tyr Ser Glu Thr Trp Leu Ala Leu Ile Glu Arg Gly Gly Cys Thr Phe 
            100                 105                 110         


Thr Gln Lys Ile Lys Val Ala Thr Glu Lys Gly Ala Ser Gly Val Ile 
        115                 120                 125             


Ile Tyr Asn Val Pro Gly Thr Gly Asn Gln Val Phe Pro Met Phe His 
    130                 135                 140                 


Gln Ala Phe Glu Asp Val Val Val Val Met Ile Gly Asn Leu Lys Gly 
145                 150                 155                 160 


Thr Glu Ile Phe His Leu Ile Lys Lys Gly Val Leu Ile Thr Ala Val 
                165                 170                 175     


Val Glu Val Gly Arg Lys His Ile Ile Trp Met Asn His Tyr Leu Val 
            180                 185                 190         


Ser Phe Val Ile Val Thr Thr Ala Thr Leu Ala Tyr Phe Ile Phe Tyr 
        195                 200                 205             


His Ile His Arg Leu Cys Leu Ala Arg Ile Gln Asn Arg Arg Trp Gln 
    210                 215                 220                 


Arg Leu Thr Thr Asp Leu Gln Asn Thr Phe Gly Gln Leu Gln Leu Arg 
225                 230                 235                 240 


Val Val Lys Glu Gly Asp Glu Glu Ile Asn Pro Asn Gly Asp Ser Cys 
                245                 250                 255     


Val Ile Cys Phe Glu Arg Tyr Lys Pro Asn Asp Ile Val Arg Ile Leu 
            260                 265                 270         


Thr Cys Lys His Phe Phe His Lys Asn Cys Ile Asp Pro Trp Ile Leu 
        275                 280                 285             


Pro His Gly Thr Cys Pro Ile Cys Lys Cys Asp Ile Leu Lys Val Leu 
    290                 295                 300                 


Gly Ile Gln Val Val Val Glu Asn Gly Thr Glu Pro Leu Gln Val Leu 
305                 310                 315                 320 


Met Ser Asn Glu Leu Pro Glu Thr Leu Ser Pro Ser Glu Glu Glu Thr 
                325                 330                 335     


Asn Asn Glu Val Ser Pro Ala Gly Thr Ser Asp Lys Val Ile His Val 
            340                 345                 350         


Glu Glu Asn Pro Thr Ser Gln Asn Asn Asp Ile Gln Pro His Ser Val 
        355                 360                 365             


Val Glu Asp Val His Pro Ser Pro 
    370                 375     


<210>  2111
<211>  1328
<212>  DNA
<213>  Homosapiens

<400>  2111
gtaccaatca caagtcttgt tattttgttt cattatgaga aagataatct actaaatatt     60

aaaatactgg aaggagcaag atagctttga tccagggaga ccttttccat ttatgtgctt    120

tagtaatctg ccgccaacaa gctatcttct ttatgttctt ctacaactga tgttgttttg    180

ttttctcatg tttgtctctt aatagacaaa tggaggcatg agcttcctta gaattacccc    240

ttcgacgcat agttctgttt catctggact tttgaggctt agtatctttc tactacttag    300

ctttcctgac tcaaacggaa aagccatttg gacagctcac ctgaatataa catttcaggt    360

tggaaatgag atcacatcgg aattaggaga gagtggagtg ttcgggaatc attctcctct    420

ggaaagggtg tctggtgtgg tggcacttcc tgaaggatgg aatcagaatg cctgtcatcc    480

tttgaccaat ttcagcaggc ccaaacaggc agactcatgg ctggccctca tcgaacgtgg    540

aggctgtact tttacacata aaatcaacgt ggcagcagag aagggagcaa atggggtgat    600

catctacaac tatcaaggta cgggcagtaa agtatttccc atgtctcacc aggggacgga    660

aaatatagtc gcggtgatga taagcaacct gaaaggcatg gaaattttgc actcgattca    720

gaaaggagtc tatgtgacag tcatcattga agtggggaga atgcacatgc agtgggtgag    780

ccattacatc atgtatctat ttaccttcct ggctgccaca attgcctact tttacttaga    840

ttgcgtctgg agacttacac ctagagtgcc caattctttc accaggaggc gaagtcaaat    900

aaagacagat gtgaagaaag ctattgacca gcttcaactg cgagttctca aagaagggga    960

tgaggaatta gacctaaatg aagacaactg tgttgtttgc tttgacacat acaaacccca   1020

agatgtagta cgcattttaa cttgcaaaca ttttttccat aaggcatgca ttgacccctg   1080

gcttttagcc cataggacat gtcccatgtg caagtgtgac atcctgaaaa cttaagaaat   1140

ctggagaatt ttctgaagat gtaaccagat ctttccaaat acaaagatta gataaattgt   1200

cttattgtac tttatgtaga gagaaaattt cagcttctct acccaagtat gaacaagggt   1260

gaaatttgtg ttttaaaaat aaaactcctt atcatgccca gcaaaaaaaa aaaaaaaaaa   1320

aaaaaaaa                                                            1328


<210>  2112
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  2112

Met Ser Phe Leu Arg Ile Thr Pro Ser Thr His Ser Ser Val Ser Ser 
1               5                   10                  15      


Gly Leu Leu Arg Leu Ser Ile Phe Leu Leu Leu Ser Phe Pro Asp Ser 
            20                  25                  30          


Asn Gly Lys Ala Ile Trp Thr Ala His Leu Asn Ile Thr Phe Gln Val 
        35                  40                  45              


Gly Asn Glu Ile Thr Ser Glu Leu Gly Glu Ser Gly Val Phe Gly Asn 
    50                  55                  60                  


His Ser Pro Leu Glu Arg Val Ser Gly Val Val Ala Leu Pro Glu Gly 
65                  70                  75                  80  


Trp Asn Gln Asn Ala Cys His Pro Leu Thr Asn Phe Ser Arg Pro Lys 
                85                  90                  95      


Gln Ala Asp Ser Trp Leu Ala Leu Ile Glu Arg Gly Gly Cys Thr Phe 
            100                 105                 110         


Thr His Lys Ile Asn Val Ala Ala Glu Lys Gly Ala Asn Gly Val Ile 
        115                 120                 125             


Ile Tyr Asn Tyr Gln Gly Thr Gly Ser Lys Val Phe Pro Met Ser His 
    130                 135                 140                 


Gln Gly Thr Glu Asn Ile Val Ala Val Met Ile Ser Asn Leu Lys Gly 
145                 150                 155                 160 


Met Glu Ile Leu His Ser Ile Gln Lys Gly Val Tyr Val Thr Val Ile 
                165                 170                 175     


Ile Glu Val Gly Arg Met His Met Gln Trp Val Ser His Tyr Ile Met 
            180                 185                 190         


Tyr Leu Phe Thr Phe Leu Ala Ala Thr Ile Ala Tyr Phe Tyr Leu Asp 
        195                 200                 205             


Cys Val Trp Arg Leu Thr Pro Arg Val Pro Asn Ser Phe Thr Arg Arg 
    210                 215                 220                 


Arg Ser Gln Ile Lys Thr Asp Val Lys Lys Ala Ile Asp Gln Leu Gln 
225                 230                 235                 240 


Leu Arg Val Leu Lys Glu Gly Asp Glu Glu Leu Asp Leu Asn Glu Asp 
                245                 250                 255     


Asn Cys Val Val Cys Phe Asp Thr Tyr Lys Pro Gln Asp Val Val Arg 
            260                 265                 270         


Ile Leu Thr Cys Lys His Phe Phe His Lys Ala Cys Ile Asp Pro Trp 
        275                 280                 285             


Leu Leu Ala His Arg Thr Cys Pro Met Cys Lys Cys Asp Ile Leu Lys 
    290                 295                 300                 


Thr 
305 


<210>  2113
<211>  3811
<212>  DNA
<213>  Homosapiens

<400>  2113
ctattgaagc cacctgctca ggacaatgaa attcttcagt tacattctgg tttatcgccg     60

atttctcttc gtggttttca ctgtgttggt tttactacct ctgcccatcg tcctccacac    120

caaggaagca gaatgtgcct acacactctt tgtggtcgcc acattttggc tcacagaagc    180

attgcctctg tcggtaacag ctttgctacc tagtttaatg ttacccatgt ttgggatcat    240

gccttctaag aaggtggcat ctgcttattt caaggatttt cacttactgc taattggagt    300

tatctgttta gcaacatcca tagaaaaatg gaatttgcac aagagaattg ctctgaaaat    360

ggtgatgatg gttggtgtaa atcctgcatg gctgacgctg gggttcatga gcagcactgc    420

ctttttgtct atgtggctca gcaacacctc gacggctgcc atggtgatgc ccattgcgga    480

ggctgtagtg cagcagatca tcaatgcaga agcagaggtc gaggccactc agatgactta    540

cttcaacgga tcaaccaacc acggactaga aattgatgaa agtgttaatg gacatgaaat    600

aaatgagagg aaagagaaaa caaaaccagt tccaggatac aataatgata cagggaaaat    660

ttcaagcaag gtggagttgg aaaagaactc aggcatgaga accaaatatc gaacaaagaa    720

gggccacgtg acacgtaaac ttacgtgttt gtgcattgcc tactcttcta ccattggtgg    780

actgacaaca atcactggta cctccaccaa cttgatcttt gcagagtatt tcaatacacg    840

ctatcctgac tgtcgttgcc tcaactttgg atcatggttt acgttttcct tcccagctgc    900

ccttatcatt ctactcttat cctggatctg gcttcagtgg cttttcctag gattcaattt    960

taaggagatg ttcaaatgtg gcaaaaccaa aacagtccaa caaaaagctt gtgctgaggt   1020

gattaagcaa gaataccaaa agcttgggcc aataaggtat caagaaattg tgaccttggt   1080

cctcttcatt ataatggctc tgctatggtt tagtcgagac cccggatttg ttcctggttg   1140

gtctgcactt ttttcagagt accctggttt tgctacagat tcaactgttg ctttacttat   1200

agggctgcta ttctttctta tcccagctaa gacactgact aaaactacac ctacaggaga   1260

aattgttgct tttgattact ctccactgat tacttggaaa gaattccagt cattcatgcc   1320

ctgggatata gccattcttg ttggtggagg gtttgccctg gcagatggtt gtgaggagtc   1380

tggattatct aagtggatag gaaataaatt atctcctctg ggttcattac cagcatggct   1440

aataattctg atatcttctt tgatggtgac atctttaact gaggtagcca gcaatccagc   1500

taccattaca ctctttctcc caatattatc tccattggcc gaagccattc atgtgaaccc   1560

tctttatatt ctgatacctt ctactctgtg tacttcattt gcattcctcc taccagtagc   1620

aaatccaccc aatgctattg tcttttcata tggtcatctg aaagtcattg acatggttaa   1680

agctggactt ggtgtcaaca ttgttggtgt tgctgtggtt atgcttggca tatgtacttg   1740

gattgtaccc atgtttgacc tctacactta cccttcgtgg gctcctgcta tgagtaatga   1800

gaccatgcca taataagcac aaaatttctg actatcttgc ggtaatttct ggaagacatt   1860

aatgattgac tgtaaaatgt ggctctaaat aactaatgac acacatttaa atcagttatg   1920

gtgtagctgc tgcaattccc gtgaataccc gaaacctgct gttataactc agagtccata   1980

tttgttattg cagtgcaact aaagagcatc tatgtgcctt catcaagaag cccatgtttt   2040

gagattttgc tcatgaacca tctgcaactt gcttcatcat aagaataatt tataacttga   2100

ccttcaaaga gattagagca tttgtttcat cttacagttg gagttcaatg taacatttta   2160

aatgcaattt attatttcag aaatttccca tgaaactaaa aatagaaaat aagatataca   2220

agttaattcg gtacttggat aaatcatttc tgcattgttg ttccagagaa tttgctgaga   2280

aatcaaagcc atggtcatct ggtgatgaag agaaaagttt aatctaaatg atatgtgcat   2340

ttcctcattt aaaaaatcca attggattat tcttaatata tacatgtaat atgaaaattg   2400

agattgaagc actaattcca aaattatggc tgaatatact aaataacaga aaagttacag   2460

ataagaattt atttctactg aactctatag ttagtgtaat ataattcata tttttatgat   2520

attggcacac tgagaaattc attttgtaga gctatggata aggcttgcta tgatttgcac   2580

tattagtaca gtatagttag aaaggaaagc tgaacactat aaaactatta acatattttc   2640

gtatatgagt aacaactttg cttaagtgtt tatcttagtt cagaaataca taatgtcata   2700

tgttaaaaat aaagagatgt agaaatctaa atgaattatc actgtgtata cagacagaaa   2760

aatcacataa ctctggtgtg ttaacattgc aatgaaaaaa tgaaaaaaag aaggaaaaaa   2820

gaataagaat gaaaactgct gacgtattac aaaacagaaa aataaatgat ttaaaatcaa   2880

atcaaaaaga aaaaactaaa catttaaaca aaaatgggat aagaatagtc ttctagaagt   2940

gaggatgcga aaaagaatga gtttccaatt accctgatgt gacaattaca cattgtagac   3000

aggtagcaaa atatcacata cacccccaaa atatgtacaa atattatata tcaataaata   3060

aatttttaaa gagtaagtgc tattggcatt ccaaaattca gctaaaggaa aaatgatcaa   3120

aaacaaagta aggtgcacag ttagcaaaag atgcagatgt tatatcacag caattctcat   3180

gctaaaaata caacaaaaga caaagcaaaa aataaacctt tgcttttttt tttttttttt   3240

tttttttgag acggagtctc gctctgtcgc ccaggctgga gtgcagtggc gggatctcgg   3300

ctcactgcaa gctccgcctc ccaggttcac gccattctcc tgcctcagcc aaacctttgc   3360

tatttttaat cttcgttggc actttccagc tgttactgac cttgtcattt tttattcaaa   3420

taagattatt tacaaactta ttcttgaaac taaatatagt aaagagggtt tttaaaataa   3480

tatttaacat acgaattatt aattggccat gttcattatt tatctatgtt tattaatggg   3540

ccaatgcaaa aaatcatttt ttcaaagaaa aatttgtcca tgtaaagctt aaattataat   3600

attgctgctt tgtataactc ttctatgttt attctattca tttgttcctt tccctaccat   3660

attttacaca tgtatttata atctgtagta tttattacat ttctgctttt ttctagtcat   3720

tcaatttatc actgctgaat tgcatcagat catggatgca tttttattat gaaaaaataa   3780

aatgactttt caaattaaaa aaaaaaaaaa a                                  3811


<210>  2114
<211>  595
<212>  PRT
<213>  Homosapiens

<400>  2114

Met Lys Phe Phe Ser Tyr Ile Leu Val Tyr Arg Arg Phe Leu Phe Val 
1               5                   10                  15      


Val Phe Thr Val Leu Val Leu Leu Pro Leu Pro Ile Val Leu His Thr 
            20                  25                  30          


Lys Glu Ala Glu Cys Ala Tyr Thr Leu Phe Val Val Ala Thr Phe Trp 
        35                  40                  45              


Leu Thr Glu Ala Leu Pro Leu Ser Val Thr Ala Leu Leu Pro Ser Leu 
    50                  55                  60                  


Met Leu Pro Met Phe Gly Ile Met Pro Ser Lys Lys Val Ala Ser Ala 
65                  70                  75                  80  


Tyr Phe Lys Asp Phe His Leu Leu Leu Ile Gly Val Ile Cys Leu Ala 
                85                  90                  95      


Thr Ser Ile Glu Lys Trp Asn Leu His Lys Arg Ile Ala Leu Lys Met 
            100                 105                 110         


Val Met Met Val Gly Val Asn Pro Ala Trp Leu Thr Leu Gly Phe Met 
        115                 120                 125             


Ser Ser Thr Ala Phe Leu Ser Met Trp Leu Ser Asn Thr Ser Thr Ala 
    130                 135                 140                 


Ala Met Val Met Pro Ile Ala Glu Ala Val Val Gln Gln Ile Ile Asn 
145                 150                 155                 160 


Ala Glu Ala Glu Val Glu Ala Thr Gln Met Thr Tyr Phe Asn Gly Ser 
                165                 170                 175     


Thr Asn His Gly Leu Glu Ile Asp Glu Ser Val Asn Gly His Glu Ile 
            180                 185                 190         


Asn Glu Arg Lys Glu Lys Thr Lys Pro Val Pro Gly Tyr Asn Asn Asp 
        195                 200                 205             


Thr Gly Lys Ile Ser Ser Lys Val Glu Leu Glu Lys Asn Ser Gly Met 
    210                 215                 220                 


Arg Thr Lys Tyr Arg Thr Lys Lys Gly His Val Thr Arg Lys Leu Thr 
225                 230                 235                 240 


Cys Leu Cys Ile Ala Tyr Ser Ser Thr Ile Gly Gly Leu Thr Thr Ile 
                245                 250                 255     


Thr Gly Thr Ser Thr Asn Leu Ile Phe Ala Glu Tyr Phe Asn Thr Arg 
            260                 265                 270         


Tyr Pro Asp Cys Arg Cys Leu Asn Phe Gly Ser Trp Phe Thr Phe Ser 
        275                 280                 285             


Phe Pro Ala Ala Leu Ile Ile Leu Leu Leu Ser Trp Ile Trp Leu Gln 
    290                 295                 300                 


Trp Leu Phe Leu Gly Phe Asn Phe Lys Glu Met Phe Lys Cys Gly Lys 
305                 310                 315                 320 


Thr Lys Thr Val Gln Gln Lys Ala Cys Ala Glu Val Ile Lys Gln Glu 
                325                 330                 335     


Tyr Gln Lys Leu Gly Pro Ile Arg Tyr Gln Glu Ile Val Thr Leu Val 
            340                 345                 350         


Leu Phe Ile Ile Met Ala Leu Leu Trp Phe Ser Arg Asp Pro Gly Phe 
        355                 360                 365             


Val Pro Gly Trp Ser Ala Leu Phe Ser Glu Tyr Pro Gly Phe Ala Thr 
    370                 375                 380                 


Asp Ser Thr Val Ala Leu Leu Ile Gly Leu Leu Phe Phe Leu Ile Pro 
385                 390                 395                 400 


Ala Lys Thr Leu Thr Lys Thr Thr Pro Thr Gly Glu Ile Val Ala Phe 
                405                 410                 415     


Asp Tyr Ser Pro Leu Ile Thr Trp Lys Glu Phe Gln Ser Phe Met Pro 
            420                 425                 430         


Trp Asp Ile Ala Ile Leu Val Gly Gly Gly Phe Ala Leu Ala Asp Gly 
        435                 440                 445             


Cys Glu Glu Ser Gly Leu Ser Lys Trp Ile Gly Asn Lys Leu Ser Pro 
    450                 455                 460                 


Leu Gly Ser Leu Pro Ala Trp Leu Ile Ile Leu Ile Ser Ser Leu Met 
465                 470                 475                 480 


Val Thr Ser Leu Thr Glu Val Ala Ser Asn Pro Ala Thr Ile Thr Leu 
                485                 490                 495     


Phe Leu Pro Ile Leu Ser Pro Leu Ala Glu Ala Ile His Val Asn Pro 
            500                 505                 510         


Leu Tyr Ile Leu Ile Pro Ser Thr Leu Cys Thr Ser Phe Ala Phe Leu 
        515                 520                 525             


Leu Pro Val Ala Asn Pro Pro Asn Ala Ile Val Phe Ser Tyr Gly His 
    530                 535                 540                 


Leu Lys Val Ile Asp Met Val Lys Ala Gly Leu Gly Val Asn Ile Val 
545                 550                 555                 560 


Gly Val Ala Val Val Met Leu Gly Ile Cys Thr Trp Ile Val Pro Met 
                565                 570                 575     


Phe Asp Leu Tyr Thr Tyr Pro Ser Trp Ala Pro Ala Met Ser Asn Glu 
            580                 585                 590         


Thr Met Pro 
        595 


<210>  2115
<211>  2556
<212>  DNA
<213>  Homosapiens

<400>  2115
acgaccaaca gctgagaacg cggcgagtat ggaagctgcg tcttaggagc ctgggaaagc     60

acttcgacga gaatagtttg gtttcgtaca caggaaaatg tctaatcgac aggagaagta    120

tgaagctcag aatatagtca attcaacaga agagagtgat gatgcttttg atactgtcac    180

tattccagtt ccctcagaag agcctcaaga gtcagatcaa actgaagagc atgaatctgg    240

aatagaacaa ttcagtgaga gccatgcaat acatgttgag gagcagagtg accaaagctt    300

ttcaagcctg gaaccagaca atgaacaact catggaagag gttatatcac caagacaagt    360

ttcatatact ccgcaacatc atgaaaagca atatgcaatg cagaggccaa atgatgatag    420

tttggcattt ctggataaaa taaagtctgt aaaggaatct ttgcaagaat cagtggaaga    480

ttctctagca acagtaaaag ttgtacttat tccagtgggc caggaaattg taataccttt    540

taaggttgat accattctta aatatcttaa ggaccatttt tcacacttat taggtatccc    600

acattctgta ctgcagataa gatactcagg aaaaattctt aaaaataatg agactctagt    660

acaacatgga gttaagccac aggaaattgt acaagtggaa atcttttcta caaatccaga    720

tctgtatcca gtcagaagaa tagatggatt aactgatgtc tctcaaatca taactgtcac    780

tgtccaaact ggacttgatc aataccagca ggtacctgtt gagattgtca aatctgactt    840

tcacaaacca tctcttggtg gattcagaca taaagtaaca ggagtagagt atcacaatgc    900

tggaacacaa actgtaccta aaaggattcc cgaaagactc agtatatttt gtagggatac    960

gcagacagtt tttcagaaaa aaaatctcca acaaactaca aatacaacat ccacacagat   1020

gactaacatt ggtgtatatg tatcaaatat gactgataaa ctggtaacac caggaaagta   1080

tttttcagca gcagaatacc atgctcaaag actaaaggcg gtgacagtga tacagactta   1140

ctacaggcaa tggcatgcta aaatcttcgt agagaattta agaagacaga aaagcttaag   1200

actggaatgg gaaacacagc aagaactaag gaagataaga gaaaaagaag aatggataaa   1260

attggactat caccggaggc ataatcctaa aacaaatgaa gattttgaat ttctttataa   1320

tgcattagaa ttctggcggc aagaagaact tacacgtatt aaccaatctt ttactggagc   1380

tgaaaggaaa gctgctctgt gtgaacttct ggaaaaagag actcagataa ttgcttccat   1440

tgggagacat agatacattg cttatatggc aaatcaggaa gcagcaatac aagctttttt   1500

ggataagtgt tcagctccaa aaatatggag aacccctaat ggcaaaacaa ttgagatgga   1560

tacgcagttc accatcagag ccagagagct gcaaaatatc tataagtgca ttatgctgaa   1620

aaatatctcc caagatgaga ggctggatgt gctgttaact cttaaacaca ctgtaaagga   1680

acatgaatgt aaactaactc aggaaattct agaattgatt gacagagagg ttgaccttat   1740

gatgagagga gtcaaacatc ataaccttga aggactcaga aaaagaattg cgacactctt   1800

ttttcattat atcaaaacac ctctgtttaa tcctgaagtt gcaaaatacc ttaaggtccc   1860

tcaagaccca ttgaaatttt ataagaagat ttacttttgc cacagttgcc agctttattt   1920

gccttctaca gaattttctg tatcatccac ctcacgccgc atataccggt gtcgtaactg   1980

cattaacctt cagaatgagg ctcaaaaacg agaatcattt ttgaagtaca aatgtttact   2040

tcaacagctc tactatacag aagctgatta tgaagatgat tctaaaattg ctttcttgat   2100

gcagctacaa gacattcagt acctgacaga gaacatctgg gcgtcccagt cagtcctcag   2160

tgcttgcgac aatctcagtg atctggtcat ggtcagatgg aataaatccc tggagtggtc   2220

cccctggaac tgcattcttc ttaccaaaga tgaagcagct gctcatctca agctaacaag   2280

tattgaagag ggatatgaac gctcatttat tcacaagatc aaacacaaac atatcctggc   2340

taagaactat ttttctcagg ttccagtgct ggcttcattt atacttgatg atggtgaaat   2400

tgatgagatc agatggaagt atcactcaga cacaacacct aagattatag aatcccagag   2460

gcctcctcat taggtgatcc aggagtattt gtttgatgat cggcattttg ttcactgcta   2520

atagggtaat acagaggtca cagagtatgg aaatgg                             2556


<210>  2116
<211>  791
<212>  PRT
<213>  Homosapiens

<400>  2116

Met Ser Asn Arg Gln Glu Lys Tyr Glu Ala Gln Asn Ile Val Asn Ser 
1               5                   10                  15      


Thr Glu Glu Ser Asp Asp Ala Phe Asp Thr Val Thr Ile Pro Val Pro 
            20                  25                  30          


Ser Glu Glu Pro Gln Glu Ser Asp Gln Thr Glu Glu His Glu Ser Gly 
        35                  40                  45              


Ile Glu Gln Phe Ser Glu Ser His Ala Ile His Val Glu Glu Gln Ser 
    50                  55                  60                  


Asp Gln Ser Phe Ser Ser Leu Glu Pro Asp Asn Glu Gln Leu Met Glu 
65                  70                  75                  80  


Glu Val Ile Ser Pro Arg Gln Val Ser Tyr Thr Pro Gln His His Glu 
                85                  90                  95      


Lys Gln Tyr Ala Met Gln Arg Pro Asn Asp Asp Ser Leu Ala Phe Leu 
            100                 105                 110         


Asp Lys Ile Lys Ser Val Lys Glu Ser Leu Gln Glu Ser Val Glu Asp 
        115                 120                 125             


Ser Leu Ala Thr Val Lys Val Val Leu Ile Pro Val Gly Gln Glu Ile 
    130                 135                 140                 


Val Ile Pro Phe Lys Val Asp Thr Ile Leu Lys Tyr Leu Lys Asp His 
145                 150                 155                 160 


Phe Ser His Leu Leu Gly Ile Pro His Ser Val Leu Gln Ile Arg Tyr 
                165                 170                 175     


Ser Gly Lys Ile Leu Lys Asn Asn Glu Thr Leu Val Gln His Gly Val 
            180                 185                 190         


Lys Pro Gln Glu Ile Val Gln Val Glu Ile Phe Ser Thr Asn Pro Asp 
        195                 200                 205             


Leu Tyr Pro Val Arg Arg Ile Asp Gly Leu Thr Asp Val Ser Gln Ile 
    210                 215                 220                 


Ile Thr Val Thr Val Gln Thr Gly Leu Asp Gln Tyr Gln Gln Val Pro 
225                 230                 235                 240 


Val Glu Ile Val Lys Ser Asp Phe His Lys Pro Ser Leu Gly Gly Phe 
                245                 250                 255     


Arg His Lys Val Thr Gly Val Glu Tyr His Asn Ala Gly Thr Gln Thr 
            260                 265                 270         


Val Pro Lys Arg Ile Pro Glu Arg Leu Ser Ile Phe Cys Arg Asp Thr 
        275                 280                 285             


Gln Thr Val Phe Gln Lys Lys Asn Leu Gln Gln Thr Thr Asn Thr Thr 
    290                 295                 300                 


Ser Thr Gln Met Thr Asn Ile Gly Val Tyr Val Ser Asn Met Thr Asp 
305                 310                 315                 320 


Lys Leu Val Thr Pro Gly Lys Tyr Phe Ser Ala Ala Glu Tyr His Ala 
                325                 330                 335     


Gln Arg Leu Lys Ala Val Thr Val Ile Gln Thr Tyr Tyr Arg Gln Trp 
            340                 345                 350         


His Ala Lys Ile Phe Val Glu Asn Leu Arg Arg Gln Lys Ser Leu Arg 
        355                 360                 365             


Leu Glu Trp Glu Thr Gln Gln Glu Leu Arg Lys Ile Arg Glu Lys Glu 
    370                 375                 380                 


Glu Trp Ile Lys Leu Asp Tyr His Arg Arg His Asn Pro Lys Thr Asn 
385                 390                 395                 400 


Glu Asp Phe Glu Phe Leu Tyr Asn Ala Leu Glu Phe Trp Arg Gln Glu 
                405                 410                 415     


Glu Leu Thr Arg Ile Asn Gln Ser Phe Thr Gly Ala Glu Arg Lys Ala 
            420                 425                 430         


Ala Leu Cys Glu Leu Leu Glu Lys Glu Thr Gln Ile Ile Ala Ser Ile 
        435                 440                 445             


Gly Arg His Arg Tyr Ile Ala Tyr Met Ala Asn Gln Glu Ala Ala Ile 
    450                 455                 460                 


Gln Ala Phe Leu Asp Lys Cys Ser Ala Pro Lys Ile Trp Arg Thr Pro 
465                 470                 475                 480 


Asn Gly Lys Thr Ile Glu Met Asp Thr Gln Phe Thr Ile Arg Ala Arg 
                485                 490                 495     


Glu Leu Gln Asn Ile Tyr Lys Cys Ile Met Leu Lys Asn Ile Ser Gln 
            500                 505                 510         


Asp Glu Arg Leu Asp Val Leu Leu Thr Leu Lys His Thr Val Lys Glu 
        515                 520                 525             


His Glu Cys Lys Leu Thr Gln Glu Ile Leu Glu Leu Ile Asp Arg Glu 
    530                 535                 540                 


Val Asp Leu Met Met Arg Gly Val Lys His His Asn Leu Glu Gly Leu 
545                 550                 555                 560 


Arg Lys Arg Ile Ala Thr Leu Phe Phe His Tyr Ile Lys Thr Pro Leu 
                565                 570                 575     


Phe Asn Pro Glu Val Ala Lys Tyr Leu Lys Val Pro Gln Asp Pro Leu 
            580                 585                 590         


Lys Phe Tyr Lys Lys Ile Tyr Phe Cys His Ser Cys Gln Leu Tyr Leu 
        595                 600                 605             


Pro Ser Thr Glu Phe Ser Val Ser Ser Thr Ser Arg Arg Ile Tyr Arg 
    610                 615                 620                 


Cys Arg Asn Cys Ile Asn Leu Gln Asn Glu Ala Gln Lys Arg Glu Ser 
625                 630                 635                 640 


Phe Leu Lys Tyr Lys Cys Leu Leu Gln Gln Leu Tyr Tyr Thr Glu Ala 
                645                 650                 655     


Asp Tyr Glu Asp Asp Ser Lys Ile Ala Phe Leu Met Gln Leu Gln Asp 
            660                 665                 670         


Ile Gln Tyr Leu Thr Glu Asn Ile Trp Ala Ser Gln Ser Val Leu Ser 
        675                 680                 685             


Ala Cys Asp Asn Leu Ser Asp Leu Val Met Val Arg Trp Asn Lys Ser 
    690                 695                 700                 


Leu Glu Trp Ser Pro Trp Asn Cys Ile Leu Leu Thr Lys Asp Glu Ala 
705                 710                 715                 720 


Ala Ala His Leu Lys Leu Thr Ser Ile Glu Glu Gly Tyr Glu Arg Ser 
                725                 730                 735     


Phe Ile His Lys Ile Lys His Lys His Ile Leu Ala Lys Asn Tyr Phe 
            740                 745                 750         


Ser Gln Val Pro Val Leu Ala Ser Phe Ile Leu Asp Asp Gly Glu Ile 
        755                 760                 765             


Asp Glu Ile Arg Trp Lys Tyr His Ser Asp Thr Thr Pro Lys Ile Ile 
    770                 775                 780                 


Glu Ser Gln Arg Pro Pro His 
785                 790     


<210>  2117
<211>  1550
<212>  DNA
<213>  Homosapiens

<400>  2117
tggagctaag ctgtttccag ggtgacagag tggcgacctc ggtggtcgat tgagcaggtc     60

tgagaattgt tcccaaaggg ttgtgcgtca ccgagtcgtt ggcgctgtca tggcgggtgt    120

gctgaagaag accactggcc ttgtgggatt ggctgtgtgc aatactcctc acgagaggct    180

aagaatattg tacacaaaga ttcttgatgt tcttgaggaa atccctaaaa atgcagcata    240

tagaaagtat acagaacaga ttacaaatga gaagctggct atggttaaag cggaaccaga    300

tgttaaaaaa ttagaagacc aacttcaagg cggtcaatta gaagaggtga ttcttcaggc    360

tgaacatgaa ctaaatctgg caagaaaaat gagggaatgg aaactatggg agccattagt    420

ggaagagcct cctgccgatc agtggaaatg gccaatataa ttattaagtg actttggtgt    480

gttcatggga aactgatgta attaaatatt ctgttatatt aagagcgtgt tcttattact    540

gacattttgt aatcaagaaa agtgatatag aaaatatgta ggagactgtt aaaattggtg    600

attatggtaa tatggtcatg tgaatcaatt tttgatttat aaagtactca cacaagttgt    660

ttcaaagatg atatttctgt gaacagagag gccatgggaa gatttgaaaa ttattaaaga    720

aaaattccta cagattttca atgcagagac cataatcaaa aagtaaactt tctttagtag    780

tatgttcaat acatcattta attttttaag ttatcctgaa gaaggaaagg tccttaatta    840

ttatagtcta aacaaattta tagattactg tttgaagtaa ataatacgag tgaatatttt    900

caaatgtgat aaaatagcac aagtggctgg tgataaaatt tgaaattatg gttaacctca    960

gctgtgatct tatgtatgta aagtgaaatt taaatagata attataggtt gattacaaaa   1020

tccatagtgt cattttattt tagtcattat tgaattatac catttactct gttttcttat   1080

agtcttaatt ttattatatt ttgttgttac tgtattatat ttgaaaacct tcaaattaga   1140

atacattgta cagttaaaga aattgacttg gtacttaaaa gaaagatttc ccattgcata   1200

caggttattg gagaaatttt ccttttgttg catttgtgga agttagtttt ctggcccgtg   1260

gcctttaatt ttcttaatca acctaattac atcaggatag aggtagagtt tctgtaaaag   1320

aagagacatt aagagttcct gaaatttata tctggcatac cgataggctt atattcaaaa   1380

catcttagtc atacgaccat aaattaaaag tggagtcact aaatagtttg cagtacgttt   1440

ctaatataag tgtaggtggg tatcaaaaca agacaaatgc tgttcaggga aagaagttgg   1500

caagcttaag gttaaacaaa aataaaatta catgtgtttt cgccttccta              1550


<210>  2118
<211>  116
<212>  PRT
<213>  Homosapiens

<400>  2118

Met Ala Gly Val Leu Lys Lys Thr Thr Gly Leu Val Gly Leu Ala Val 
1               5                   10                  15      


Cys Asn Thr Pro His Glu Arg Leu Arg Ile Leu Tyr Thr Lys Ile Leu 
            20                  25                  30          


Asp Val Leu Glu Glu Ile Pro Lys Asn Ala Ala Tyr Arg Lys Tyr Thr 
        35                  40                  45              


Glu Gln Ile Thr Asn Glu Lys Leu Ala Met Val Lys Ala Glu Pro Asp 
    50                  55                  60                  


Val Lys Lys Leu Glu Asp Gln Leu Gln Gly Gly Gln Leu Glu Glu Val 
65                  70                  75                  80  


Ile Leu Gln Ala Glu His Glu Leu Asn Leu Ala Arg Lys Met Arg Glu 
                85                  90                  95      


Trp Lys Leu Trp Glu Pro Leu Val Glu Glu Pro Pro Ala Asp Gln Trp 
            100                 105                 110         


Lys Trp Pro Ile 
        115     


<210>  2119
<211>  2706
<212>  DNA
<213>  Homosapiens

<400>  2119
gtagattagc tcaacactcg agaatcattg cagcttcaag gaatggatac taatgatgac     60

cctgatgaag accatcttac aagttatgat attcagctaa gtattcaaga atccattgaa    120

gccagcaaga ctgcactttg tcctgaaaga tttgtacccc taagtgctca aaacagaaaa    180

cttgtggagg ccataaaaca aggtcacatt cctgagctcc aggagtatgt aaaatataaa    240

tatgcaatgg atgaagctga tgaaaaagga tggtttccat tgcatgaagc tgttgttcaa    300

cccattcaac aaatacttga gattgttctg gatgcatcct ataagacact ctgggaattc    360

aagacctgtg atggagaaac acccttgact ttggcagtca aagctggtct ggtggaaaat    420

gtaagaactt tattagaaaa gggagtgtgg cccaacacaa aaaatgataa aggagagacc    480

ccccttctga ttgctgtgaa aaagggctcc tatgacatgg tgtcgactct gatcaaacat    540

aacactagcc tagaccagcc ctgtgtcaag cgatggtcag caatgcatga agcagccaag    600

caaggccgaa aagatatcgt agctctgctg ctgaaacatg gaggcaatgt ccacctgaga    660

gatggatttg gagtcacacc actaggcgtc gctgccgagt atggtcactg tgacgtgtta    720

gaacatctaa tccacaaagg tggtgatgtg cttgctttgg cggatgatgg ggcgtcggtg    780

ctgtttgagg cagcaggagg tggcaatccc gactgcattt ccctcctgct ggaatatgga    840

ggaagcggaa atgtacctaa ccgagcagga catcttccta tacaccgagc tgcctatgag    900

gggcattatc ttgcactgaa atatcttatc ccagtaacat ctaaaaatgc aattcggaaa    960

agtgggctaa caccaattca ctcagcagca gatggacaaa atgcacagtg tctagaactg   1020

ctcattgaaa atggttttga tgtcaacact ctacttgctg accacatttc ccagagctat   1080

gacgatgaga ggaagactgc gctgtatttt ggcgtttcta ataatgacgt tcattgcaca   1140

gaagtccttc tggctgcagg tgcagaccca aacttagatc ccctcaactg tctacttgtt   1200

gcagtgaggg ccaataatta tgaaattgtc aggctgcttc tctcccatgg agctaatgtc   1260

aattgttatt ttatgcatgt gaatgacact cgtttcccca gtgtcattca atatgctcta   1320

aacgacgagg taatgctgag gctattgctg aataatggct atcaagtgga gatgtgcttt   1380

gactgcatgc atggtgacat ctttggaaat tcatttgtgt ggtcagagat acaggaagag   1440

gtgctgccag gatggacatc ttgtgtaata aaagataacc cgttctgtga gtttattaca   1500

gttccttgga tgaagcactt ggtaggcaga gttactcgtg tactaataga ttacatggat   1560

tatgttcctc tgtgtgctaa actgaagtct gcactagaag tacagagaga atggccagaa   1620

atccgccaaa tactagagaa tccttgttca ttgaagcatt tgtgtcggtt aaaaattcga   1680

aggcttatgg gtctccagaa actctgccag ccagcctcag tggagaagct tcctctacca   1740

ccagctattc aaagatacat attatttaaa gagtatgatc tctatggaca agagctaaaa   1800

ttgacataac ttaatatttt aaaatgtgat ttaaaaaaaa tgttgaaatg tgattccctc   1860

agataatttc ttgtaaccat tttacatcct taattgtaaa gtgtatttaa attcattgac   1920

agttttatag gttatcatgt gttcttatgg gaacaccatg atttatgtct ttaaagacat   1980

ttgcattttt taaagatagt attttgaact tagatttgta tctttgtttg ctacaagtca   2040

tcaaactctc cctatcaagt ggctcctaca atatccacaa tcaagtctct atgtttaaaa   2100

aacagataac cactttctca aacccacatc tgccagttgc tggccagatt ctcctgtctt   2160

tcacggtctt gctgtgtaaa agagctcctc ctgcctgtaa gttcacagac tgtgatctgg   2220

catctgaccc tccactgctt ttctcaaggt ccctgacaat ctctttgttg gtaaattcag   2280

tgaacattct tcagtccctc ttccaatcga ttcctacagc atctaacatt gttgcctgtt   2340

ccttgcttga aatgatatct ctttccttgt ttctcgcaaa acctgttctc ttgggtgtcc   2400

tcccacctcc ctggacactc tgtctctggc ttctttctgc ctagctcatc tctagccaat   2460

cttacagtta tatatcttaa gccctcttct ctttgttctt taagttatat atcctaagcc   2520

ctctttgctt tgttctctgg gatattttat ccacatccat ggtcttaatc attttgctag   2580

agactacaaa atttccatcc aaagctcagc tctttctctc atgttctcct gacctatgta   2640

gacaattggc ctcatgaaca tttgaacaca aagacacctc aaattcaaca tgtccccaga   2700

tgaact                                                              2706


<210>  2120
<211>  588
<212>  PRT
<213>  Homosapiens

<400>  2120

Met Asp Thr Asn Asp Asp Pro Asp Glu Asp His Leu Thr Ser Tyr Asp 
1               5                   10                  15      


Ile Gln Leu Ser Ile Gln Glu Ser Ile Glu Ala Ser Lys Thr Ala Leu 
            20                  25                  30          


Cys Pro Glu Arg Phe Val Pro Leu Ser Ala Gln Asn Arg Lys Leu Val 
        35                  40                  45              


Glu Ala Ile Lys Gln Gly His Ile Pro Glu Leu Gln Glu Tyr Val Lys 
    50                  55                  60                  


Tyr Lys Tyr Ala Met Asp Glu Ala Asp Glu Lys Gly Trp Phe Pro Leu 
65                  70                  75                  80  


His Glu Ala Val Val Gln Pro Ile Gln Gln Ile Leu Glu Ile Val Leu 
                85                  90                  95      


Asp Ala Ser Tyr Lys Thr Leu Trp Glu Phe Lys Thr Cys Asp Gly Glu 
            100                 105                 110         


Thr Pro Leu Thr Leu Ala Val Lys Ala Gly Leu Val Glu Asn Val Arg 
        115                 120                 125             


Thr Leu Leu Glu Lys Gly Val Trp Pro Asn Thr Lys Asn Asp Lys Gly 
    130                 135                 140                 


Glu Thr Pro Leu Leu Ile Ala Val Lys Lys Gly Ser Tyr Asp Met Val 
145                 150                 155                 160 


Ser Thr Leu Ile Lys His Asn Thr Ser Leu Asp Gln Pro Cys Val Lys 
                165                 170                 175     


Arg Trp Ser Ala Met His Glu Ala Ala Lys Gln Gly Arg Lys Asp Ile 
            180                 185                 190         


Val Ala Leu Leu Leu Lys His Gly Gly Asn Val His Leu Arg Asp Gly 
        195                 200                 205             


Phe Gly Val Thr Pro Leu Gly Val Ala Ala Glu Tyr Gly His Cys Asp 
    210                 215                 220                 


Val Leu Glu His Leu Ile His Lys Gly Gly Asp Val Leu Ala Leu Ala 
225                 230                 235                 240 


Asp Asp Gly Ala Ser Val Leu Phe Glu Ala Ala Gly Gly Gly Asn Pro 
                245                 250                 255     


Asp Cys Ile Ser Leu Leu Leu Glu Tyr Gly Gly Ser Gly Asn Val Pro 
            260                 265                 270         


Asn Arg Ala Gly His Leu Pro Ile His Arg Ala Ala Tyr Glu Gly His 
        275                 280                 285             


Tyr Leu Ala Leu Lys Tyr Leu Ile Pro Val Thr Ser Lys Asn Ala Ile 
    290                 295                 300                 


Arg Lys Ser Gly Leu Thr Pro Ile His Ser Ala Ala Asp Gly Gln Asn 
305                 310                 315                 320 


Ala Gln Cys Leu Glu Leu Leu Ile Glu Asn Gly Phe Asp Val Asn Thr 
                325                 330                 335     


Leu Leu Ala Asp His Ile Ser Gln Ser Tyr Asp Asp Glu Arg Lys Thr 
            340                 345                 350         


Ala Leu Tyr Phe Gly Val Ser Asn Asn Asp Val His Cys Thr Glu Val 
        355                 360                 365             


Leu Leu Ala Ala Gly Ala Asp Pro Asn Leu Asp Pro Leu Asn Cys Leu 
    370                 375                 380                 


Leu Val Ala Val Arg Ala Asn Asn Tyr Glu Ile Val Arg Leu Leu Leu 
385                 390                 395                 400 


Ser His Gly Ala Asn Val Asn Cys Tyr Phe Met His Val Asn Asp Thr 
                405                 410                 415     


Arg Phe Pro Ser Val Ile Gln Tyr Ala Leu Asn Asp Glu Val Met Leu 
            420                 425                 430         


Arg Leu Leu Leu Asn Asn Gly Tyr Gln Val Glu Met Cys Phe Asp Cys 
        435                 440                 445             


Met His Gly Asp Ile Phe Gly Asn Ser Phe Val Trp Ser Glu Ile Gln 
    450                 455                 460                 


Glu Glu Val Leu Pro Gly Trp Thr Ser Cys Val Ile Lys Asp Asn Pro 
465                 470                 475                 480 


Phe Cys Glu Phe Ile Thr Val Pro Trp Met Lys His Leu Val Gly Arg 
                485                 490                 495     


Val Thr Arg Val Leu Ile Asp Tyr Met Asp Tyr Val Pro Leu Cys Ala 
            500                 505                 510         


Lys Leu Lys Ser Ala Leu Glu Val Gln Arg Glu Trp Pro Glu Ile Arg 
        515                 520                 525             


Gln Ile Leu Glu Asn Pro Cys Ser Leu Lys His Leu Cys Arg Leu Lys 
    530                 535                 540                 


Ile Arg Arg Leu Met Gly Leu Gln Lys Leu Cys Gln Pro Ala Ser Val 
545                 550                 555                 560 


Glu Lys Leu Pro Leu Pro Pro Ala Ile Gln Arg Tyr Ile Leu Phe Lys 
                565                 570                 575     


Glu Tyr Asp Leu Tyr Gly Gln Glu Leu Lys Leu Thr 
            580                 585             


<210>  2121
<211>  1620
<212>  DNA
<213>  Homosapiens

<400>  2121
ttccttggag cctagcggct ctccccgcgt ccaagatggc ggcagaagca gctggtggga     60

aatacagaag cacagtcagc aaaagcaaag acccctcggg gctgctcatc tctgtgatca    120

ggactctgtc tactagtgac gatgtcgaag acagggaaaa tgaaaagggt cgccttgaag    180

aagcctacga gaaatgtgac cgtgacctgg atgaattgat tgtacagcac tacacagaat    240

tgacgacagc cattcgcaca taccagagca tcacagagcg catcactaac tcccgaaata    300

aaataaagca ggtaaaagag aacctgcttt catgcaagat gctgctgcac tgcaaacggg    360

atgagcttcg gaaactgtgg attgaaggaa ttgagcataa gcatgtcctg aacttgttgg    420

atgaaattga gaatatcaag caagtgcctc aaaagctgga acagtgcatg gccagcaagc    480

actatctcag tgccactgac atgttggtgt cagcagttga gtctttggag ggccccctgc    540

tccaggtgga aggactgagt gaccttcgac tagagcttca cagcaagaag atgaaccttc    600

acttggttct catagatgaa ctacaccggc acctgtacat caaatcgact agccgagttg    660

tgcagcgtaa caaggaaaaa gggaaaatca gctccctcgt gaaagatgct tctgttcctc    720

tgattgatgt tacaaacctc cctactcctc gaaaattcct tgatacctct cactattcta    780

ctgctggaag ctcaagtgtg agggagataa atctgcagga catcaaggaa gatttagaat    840

tggatccaga ggaaaacagc accctgttta tgggtatcct cattaagggc ttggcgaaac    900

tgaagaagat cccagaaaca gttaaggcaa tcatagagcg cttggagcag gagttgaagc    960

aaattgtgaa gaggtctaca acccaggtgg cagacagtgg ctatcagcgg ggggagaacg   1020

ttactgtgga gaaccaacca aggttgcttc tagaactgct ggagttactg tttgacaagt   1080

ttaatgctgt agccgctgca cactctgtgg tcctgggata cctgcaggac actgtagtga   1140

ctccactgac tcagcaggaa gatatcaaac tgtatgatat ggcagatgta tgggtgaaga   1200

tccaagatgt tctacagatg ctattaactg agtacttgga tatgaaaaat actcgtacgg   1260

cctctgaacc atcagctcaa ctaagctatg ccagcactgg acgagagttt gcagcctttt   1320

ttgccaagaa gaaacctcaa aggccaaaaa attctctttt caagttcgaa tcgtcctccc   1380

atgccatcag tatgagcgcc tatctgcgag aacagagaag ggagctctat agtcggagtg   1440

gagaactgca agggtagcgg cgaagaaatc caccagaaag acaatcaaag taacattaaa   1500

aagctcaaat tttacaaaag ttaagttcct gccaacattt tcaatttatc atacaattag   1560

aaatgtgact cagtctaaca acacccaaga ggataaaagg attaaaaaaa aaaaaaaaaa   1620


<210>  2122
<211>  473
<212>  PRT
<213>  Homosapiens

<400>  2122

Met Ala Ala Glu Ala Ala Gly Gly Lys Tyr Arg Ser Thr Val Ser Lys 
1               5                   10                  15      


Ser Lys Asp Pro Ser Gly Leu Leu Ile Ser Val Ile Arg Thr Leu Ser 
            20                  25                  30          


Thr Ser Asp Asp Val Glu Asp Arg Glu Asn Glu Lys Gly Arg Leu Glu 
        35                  40                  45              


Glu Ala Tyr Glu Lys Cys Asp Arg Asp Leu Asp Glu Leu Ile Val Gln 
    50                  55                  60                  


His Tyr Thr Glu Leu Thr Thr Ala Ile Arg Thr Tyr Gln Ser Ile Thr 
65                  70                  75                  80  


Glu Arg Ile Thr Asn Ser Arg Asn Lys Ile Lys Gln Val Lys Glu Asn 
                85                  90                  95      


Leu Leu Ser Cys Lys Met Leu Leu His Cys Lys Arg Asp Glu Leu Arg 
            100                 105                 110         


Lys Leu Trp Ile Glu Gly Ile Glu His Lys His Val Leu Asn Leu Leu 
        115                 120                 125             


Asp Glu Ile Glu Asn Ile Lys Gln Val Pro Gln Lys Leu Glu Gln Cys 
    130                 135                 140                 


Met Ala Ser Lys His Tyr Leu Ser Ala Thr Asp Met Leu Val Ser Ala 
145                 150                 155                 160 


Val Glu Ser Leu Glu Gly Pro Leu Leu Gln Val Glu Gly Leu Ser Asp 
                165                 170                 175     


Leu Arg Leu Glu Leu His Ser Lys Lys Met Asn Leu His Leu Val Leu 
            180                 185                 190         


Ile Asp Glu Leu His Arg His Leu Tyr Ile Lys Ser Thr Ser Arg Val 
        195                 200                 205             


Val Gln Arg Asn Lys Glu Lys Gly Lys Ile Ser Ser Leu Val Lys Asp 
    210                 215                 220                 


Ala Ser Val Pro Leu Ile Asp Val Thr Asn Leu Pro Thr Pro Arg Lys 
225                 230                 235                 240 


Phe Leu Asp Thr Ser His Tyr Ser Thr Ala Gly Ser Ser Ser Val Arg 
                245                 250                 255     


Glu Ile Asn Leu Gln Asp Ile Lys Glu Asp Leu Glu Leu Asp Pro Glu 
            260                 265                 270         


Glu Asn Ser Thr Leu Phe Met Gly Ile Leu Ile Lys Gly Leu Ala Lys 
        275                 280                 285             


Leu Lys Lys Ile Pro Glu Thr Val Lys Ala Ile Ile Glu Arg Leu Glu 
    290                 295                 300                 


Gln Glu Leu Lys Gln Ile Val Lys Arg Ser Thr Thr Gln Val Ala Asp 
305                 310                 315                 320 


Ser Gly Tyr Gln Arg Gly Glu Asn Val Thr Val Glu Asn Gln Pro Arg 
                325                 330                 335     


Leu Leu Leu Glu Leu Leu Glu Leu Leu Phe Asp Lys Phe Asn Ala Val 
            340                 345                 350         


Ala Ala Ala His Ser Val Val Leu Gly Tyr Leu Gln Asp Thr Val Val 
        355                 360                 365             


Thr Pro Leu Thr Gln Gln Glu Asp Ile Lys Leu Tyr Asp Met Ala Asp 
    370                 375                 380                 


Val Trp Val Lys Ile Gln Asp Val Leu Gln Met Leu Leu Thr Glu Tyr 
385                 390                 395                 400 


Leu Asp Met Lys Asn Thr Arg Thr Ala Ser Glu Pro Ser Ala Gln Leu 
                405                 410                 415     


Ser Tyr Ala Ser Thr Gly Arg Glu Phe Ala Ala Phe Phe Ala Lys Lys 
            420                 425                 430         


Lys Pro Gln Arg Pro Lys Asn Ser Leu Phe Lys Phe Glu Ser Ser Ser 
        435                 440                 445             


His Ala Ile Ser Met Ser Ala Tyr Leu Arg Glu Gln Arg Arg Glu Leu 
    450                 455                 460                 


Tyr Ser Arg Ser Gly Glu Leu Gln Gly 
465                 470             


<210>  2123
<211>  4203
<212>  DNA
<213>  Homosapiens

<400>  2123
ttccttggag cctagcggct ctccccgcgt ccaagatggc ggcagaagca gctggtggga     60

aatacagaag cacagtcagc aaaagcaaag acccctcggg gctgctcatc tctgtgatca    120

ggactctgtc tactagtgac gatgtcgaag acagggaaaa tgaaaagggt cgccttgaag    180

aagcctacga gaaatgtgac cgtgacctgg atgaattgat tgtacagcac tacacagaat    240

tgacgacagc cattcgcaca taccagagca tcacagagcg catcactaac tcccgaaata    300

aaataaagca ggtaaaagag aacctgcttt catgcaagat gctgctgcac tgcaaacggg    360

atgagcttcg gaaactgtgg attgaaggaa ttgagcataa gcatgtcctg aacttgttgg    420

atgaaattga gaatatcaag caagtgcctc aaaagctgga acagtgcatg gccagcaagc    480

actatctcag tgccactgac atgttggtgt cagcagttga gtctttggag ggccccctgc    540

tccaggtgga aggactgagt gaccttcgac tagagcttca cagcaagaag atgaaccttc    600

acttggttct catagatgaa ctacaccggc acctgtacat caaatcgact agccgagttg    660

tgcagcgtaa caaggaaaaa gggaaaatca gctccctcgt gaaagatgct tctgttcctc    720

tgattgatgt tacaaacctc cctactcctc gaaaattcct tgatacctct cactattcta    780

ctgctggaag ctcaagtgtg agggagataa atctgcagga catcaaggaa gatttagaat    840

tggatccaga ggaaaacagc accctgttta tgggtatcct cattaagggc ttggcgaaac    900

tgaagaagat cccagaaaca gttaaggcaa tcatagagcg cttggagcag gagttgaagc    960

aaattgtgaa gaggtctaca acccaggtgg cagacagtgg ctatcagcgg ggggagaacg   1020

ttactgtgga gaaccaacca aggttgcttc tagaactgct ggagttactg tttgacaagt   1080

ttaatgctgt agccgctgca cactctgtgg tcctgggata cctgcaggac actgtagtga   1140

ctccactgac tcagcaggaa gatatcaaac tgtatgatat ggcagatgta tgggtgaaga   1200

tccaagatgt tctacagatg ctattaactg agtacttgga tatgaaaaat actcgtacgg   1260

cctctgaacc atcagctcaa ctaagctatg ccagcactgg acgagagttt gcagcctttt   1320

ttgccaagaa gaaacctcaa aggccaaaaa attctctttt caagttcgaa tcgtcctccc   1380

atgccatcag tatgagcgcc tatctgcgag aacagagaag ggagctctat agtcggagtg   1440

gagaactgca agggggtcct gatgacaact taattgaagg tggaggaaca aaatttgtct   1500

gcaaacctgg agccagaaac attaccgtca tattccaccc attactaaga tttattcagg   1560

agattgagca tgctctgggt cttggcccag ccaaacagtg tcctcttcga gagtttctca   1620

ccgtgtacat caaaaacatc tttctcaatc aagtcttggc tgagatcaac aaggagattg   1680

aaggagtcac taaaacatct gaccctttga agattctggc caacgcagac accatgaagg   1740

tgctgggagt gcagcggcct ctcctacaga gcacaatcat tgtggagaag acagttcaag   1800

acctcctgaa cctgatgcat gacttgagtg catattcaga tcaattcctc aacatggtgt   1860

gcgtgaagct ccaggagtac aaggacacct gcactgcagc ttacaggggt attgtccagt   1920

cagaagaaaa acttgtcatc agtgcatcct gggcaaaaga tgatgatatc agcagactct   1980

tgaaatctct accaaactgg atgaatatgg ctcaacccaa acagctgagg ccaaaaagag   2040

aggaggaaga agatttcata agggcagctt ttggcaagga gtctgaagtt cttattggga   2100

acctgggtga taaattaatc cctccacaag acatccttcg tgacgtcagt gacctcaaag   2160

ccttggccaa catgcatgaa agcctggaat ggttggcaag tcgaacaaag tcagctttct   2220

ccaatctttc tacatcccag atgctttctc ctgctcaaga cagccacacg aacacggatc   2280

tccccccagt gtcagagcag atcatgcaga ctctcagtga acttgccaaa tcgttccagg   2340

atatggctga ccgctgcttg cttgtcttac atctggaagt gagggttcac tgtttccact   2400

atcttatccc tcttgcaaag gaggggaact atgccattgt ggctaatgtg gaaagtatgg   2460

attatgaccc cctggtggtc aagctcaaca aagatatcag cgccattgaa gaggccatga   2520

gcgccagcct tcagcagcac aagttccagt atatcttcga aggcctgggc cacctgatct   2580

cctgcatcct cattaatggt gcccagtact tcaggcgcat cagtgagtct ggcatcaaga   2640

aaatgtgtag gaacattttt gttcttcagc agaatttgac caacatcacc atgtcgcggg   2700

aggcagacct ggactttgca aggcagtact acgagatgct ttacaacaca gctgacgagc   2760

tcctgaacct ggtggtggac cagggtgtga agtacacgga gctggagtac atccacgctc   2820

tgaccctgct gcaccgcagc cagactgggg tgggggaact gaccacccag aacacgaggc   2880

tgcagaggct caaagagatc atctgcgagc aggctgccat caagcaagcc accaaggaca   2940

agaagataac taccgtttag cagggcgtac tgcggttggt gacgggggtc ccctcagtca   3000

cactcacttt tttccttggt atgttattga gtatattctg agcttagttt tctctacagt   3060

gatactttag tggagaggag gtgtaaggat tctttctctc tggttttggc ttttcatata   3120

aatgctaaag gaaggcgaca gtacagagtg ttttggttga acaactactt taatgcagtc   3180

aaatctaacg ggactagggt gggataggga ggaaggtggt atcaaattgt tggactctga   3240

aaaacaagtg gatggattac taatatttga tttattactc aatatatata taattccagc   3300

cttggaaagt aggaaagtag gctgctacct aacttttagt cccttccaaa accatttagt   3360

agggttctat tacataaaca gtagggtttt tcctctcctg accttatccg tttacagttc   3420

aatgaaataa gtgtatgtgc attgctgtct gtctctattg ccaaaatcaa ataaatggct   3480

tctcagctgc tgtttacaac aaacttccct aaccaaaaca gaacctctaa tttagggcta   3540

ggaatagaag tcttttgatc ccagtccctg ggacagtttt gtatgctgta tcttgtacac   3600

aggttgtagg ttggtttatt gccattttgt tttatttctg ctgtataaaa accaagagcc   3660

agacaattag acaactatgg aggaatgaaa ggcaattcaa acatctgctt gattcccgcc   3720

ccgccacccc taatttctga gagaataatg gttagagaac attgcatctc acttgaaaca   3780

tcctttgggg gtaaatgatt cttaggtgct cacttggtct gagctcagct gaatgcaggg   3840

aagatgggac agagtgacat ttctcctctg tgcggcctcc agctgagcct gtctctgaat   3900

tgttccctcc cccgcaatgt gggcacttac catgttcctg gcacactgga cctcaccatg   3960

tcccccggtc accagtcctc ttgctgccca tggttcatag gtcatagaag gcagcaatgc   4020

actgactggg ccacatcttg aaaactcgtg gaaagggaaa ggggaggaga tgggactttg   4080

accacacaca gtgatgcctc acaccctgaa ggtgggggat tttgtacctg tttgtacaac   4140

tttggtcttg atgggaaaaa tggagaatta aaaagtgttt tgagaagctt aaaaaaaaaa   4200

aaa                                                                 4203


<210>  2124
<211>  974
<212>  PRT
<213>  Homosapiens

<400>  2124

Met Ala Ala Glu Ala Ala Gly Gly Lys Tyr Arg Ser Thr Val Ser Lys 
1               5                   10                  15      


Ser Lys Asp Pro Ser Gly Leu Leu Ile Ser Val Ile Arg Thr Leu Ser 
            20                  25                  30          


Thr Ser Asp Asp Val Glu Asp Arg Glu Asn Glu Lys Gly Arg Leu Glu 
        35                  40                  45              


Glu Ala Tyr Glu Lys Cys Asp Arg Asp Leu Asp Glu Leu Ile Val Gln 
    50                  55                  60                  


His Tyr Thr Glu Leu Thr Thr Ala Ile Arg Thr Tyr Gln Ser Ile Thr 
65                  70                  75                  80  


Glu Arg Ile Thr Asn Ser Arg Asn Lys Ile Lys Gln Val Lys Glu Asn 
                85                  90                  95      


Leu Leu Ser Cys Lys Met Leu Leu His Cys Lys Arg Asp Glu Leu Arg 
            100                 105                 110         


Lys Leu Trp Ile Glu Gly Ile Glu His Lys His Val Leu Asn Leu Leu 
        115                 120                 125             


Asp Glu Ile Glu Asn Ile Lys Gln Val Pro Gln Lys Leu Glu Gln Cys 
    130                 135                 140                 


Met Ala Ser Lys His Tyr Leu Ser Ala Thr Asp Met Leu Val Ser Ala 
145                 150                 155                 160 


Val Glu Ser Leu Glu Gly Pro Leu Leu Gln Val Glu Gly Leu Ser Asp 
                165                 170                 175     


Leu Arg Leu Glu Leu His Ser Lys Lys Met Asn Leu His Leu Val Leu 
            180                 185                 190         


Ile Asp Glu Leu His Arg His Leu Tyr Ile Lys Ser Thr Ser Arg Val 
        195                 200                 205             


Val Gln Arg Asn Lys Glu Lys Gly Lys Ile Ser Ser Leu Val Lys Asp 
    210                 215                 220                 


Ala Ser Val Pro Leu Ile Asp Val Thr Asn Leu Pro Thr Pro Arg Lys 
225                 230                 235                 240 


Phe Leu Asp Thr Ser His Tyr Ser Thr Ala Gly Ser Ser Ser Val Arg 
                245                 250                 255     


Glu Ile Asn Leu Gln Asp Ile Lys Glu Asp Leu Glu Leu Asp Pro Glu 
            260                 265                 270         


Glu Asn Ser Thr Leu Phe Met Gly Ile Leu Ile Lys Gly Leu Ala Lys 
        275                 280                 285             


Leu Lys Lys Ile Pro Glu Thr Val Lys Ala Ile Ile Glu Arg Leu Glu 
    290                 295                 300                 


Gln Glu Leu Lys Gln Ile Val Lys Arg Ser Thr Thr Gln Val Ala Asp 
305                 310                 315                 320 


Ser Gly Tyr Gln Arg Gly Glu Asn Val Thr Val Glu Asn Gln Pro Arg 
                325                 330                 335     


Leu Leu Leu Glu Leu Leu Glu Leu Leu Phe Asp Lys Phe Asn Ala Val 
            340                 345                 350         


Ala Ala Ala His Ser Val Val Leu Gly Tyr Leu Gln Asp Thr Val Val 
        355                 360                 365             


Thr Pro Leu Thr Gln Gln Glu Asp Ile Lys Leu Tyr Asp Met Ala Asp 
    370                 375                 380                 


Val Trp Val Lys Ile Gln Asp Val Leu Gln Met Leu Leu Thr Glu Tyr 
385                 390                 395                 400 


Leu Asp Met Lys Asn Thr Arg Thr Ala Ser Glu Pro Ser Ala Gln Leu 
                405                 410                 415     


Ser Tyr Ala Ser Thr Gly Arg Glu Phe Ala Ala Phe Phe Ala Lys Lys 
            420                 425                 430         


Lys Pro Gln Arg Pro Lys Asn Ser Leu Phe Lys Phe Glu Ser Ser Ser 
        435                 440                 445             


His Ala Ile Ser Met Ser Ala Tyr Leu Arg Glu Gln Arg Arg Glu Leu 
    450                 455                 460                 


Tyr Ser Arg Ser Gly Glu Leu Gln Gly Gly Pro Asp Asp Asn Leu Ile 
465                 470                 475                 480 


Glu Gly Gly Gly Thr Lys Phe Val Cys Lys Pro Gly Ala Arg Asn Ile 
                485                 490                 495     


Thr Val Ile Phe His Pro Leu Leu Arg Phe Ile Gln Glu Ile Glu His 
            500                 505                 510         


Ala Leu Gly Leu Gly Pro Ala Lys Gln Cys Pro Leu Arg Glu Phe Leu 
        515                 520                 525             


Thr Val Tyr Ile Lys Asn Ile Phe Leu Asn Gln Val Leu Ala Glu Ile 
    530                 535                 540                 


Asn Lys Glu Ile Glu Gly Val Thr Lys Thr Ser Asp Pro Leu Lys Ile 
545                 550                 555                 560 


Leu Ala Asn Ala Asp Thr Met Lys Val Leu Gly Val Gln Arg Pro Leu 
                565                 570                 575     


Leu Gln Ser Thr Ile Ile Val Glu Lys Thr Val Gln Asp Leu Leu Asn 
            580                 585                 590         


Leu Met His Asp Leu Ser Ala Tyr Ser Asp Gln Phe Leu Asn Met Val 
        595                 600                 605             


Cys Val Lys Leu Gln Glu Tyr Lys Asp Thr Cys Thr Ala Ala Tyr Arg 
    610                 615                 620                 


Gly Ile Val Gln Ser Glu Glu Lys Leu Val Ile Ser Ala Ser Trp Ala 
625                 630                 635                 640 


Lys Asp Asp Asp Ile Ser Arg Leu Leu Lys Ser Leu Pro Asn Trp Met 
                645                 650                 655     


Asn Met Ala Gln Pro Lys Gln Leu Arg Pro Lys Arg Glu Glu Glu Glu 
            660                 665                 670         


Asp Phe Ile Arg Ala Ala Phe Gly Lys Glu Ser Glu Val Leu Ile Gly 
        675                 680                 685             


Asn Leu Gly Asp Lys Leu Ile Pro Pro Gln Asp Ile Leu Arg Asp Val 
    690                 695                 700                 


Ser Asp Leu Lys Ala Leu Ala Asn Met His Glu Ser Leu Glu Trp Leu 
705                 710                 715                 720 


Ala Ser Arg Thr Lys Ser Ala Phe Ser Asn Leu Ser Thr Ser Gln Met 
                725                 730                 735     


Leu Ser Pro Ala Gln Asp Ser His Thr Asn Thr Asp Leu Pro Pro Val 
            740                 745                 750         


Ser Glu Gln Ile Met Gln Thr Leu Ser Glu Leu Ala Lys Ser Phe Gln 
        755                 760                 765             


Asp Met Ala Asp Arg Cys Leu Leu Val Leu His Leu Glu Val Arg Val 
    770                 775                 780                 


His Cys Phe His Tyr Leu Ile Pro Leu Ala Lys Glu Gly Asn Tyr Ala 
785                 790                 795                 800 


Ile Val Ala Asn Val Glu Ser Met Asp Tyr Asp Pro Leu Val Val Lys 
                805                 810                 815     


Leu Asn Lys Asp Ile Ser Ala Ile Glu Glu Ala Met Ser Ala Ser Leu 
            820                 825                 830         


Gln Gln His Lys Phe Gln Tyr Ile Phe Glu Gly Leu Gly His Leu Ile 
        835                 840                 845             


Ser Cys Ile Leu Ile Asn Gly Ala Gln Tyr Phe Arg Arg Ile Ser Glu 
    850                 855                 860                 


Ser Gly Ile Lys Lys Met Cys Arg Asn Ile Phe Val Leu Gln Gln Asn 
865                 870                 875                 880 


Leu Thr Asn Ile Thr Met Ser Arg Glu Ala Asp Leu Asp Phe Ala Arg 
                885                 890                 895     


Gln Tyr Tyr Glu Met Leu Tyr Asn Thr Ala Asp Glu Leu Leu Asn Leu 
            900                 905                 910         


Val Val Asp Gln Gly Val Lys Tyr Thr Glu Leu Glu Tyr Ile His Ala 
        915                 920                 925             


Leu Thr Leu Leu His Arg Ser Gln Thr Gly Val Gly Glu Leu Thr Thr 
    930                 935                 940                 


Gln Asn Thr Arg Leu Gln Arg Leu Lys Glu Ile Ile Cys Glu Gln Ala 
945                 950                 955                 960 


Ala Ile Lys Gln Ala Thr Lys Asp Lys Lys Ile Thr Thr Val 
                965                 970                 


<210>  2125
<211>  3770
<212>  DNA
<213>  Homosapiens

<400>  2125
cggacgcgtg ggctgctggg cccggtggcc gcaaaagaac tttctttctc ccgcccgaac     60

ggtcgccgcg gccaactgcc tcgcccgcct ggcagcctaa ccctccttct cttcttctcc    120

tctccggctt cgcgcggccc tgcctccctc tcgcccggcg gcatccgctt gctgctgcca    180

ccgcctcctc atcttctgcc cggccaaccg gcctgccccg ctgcagtgat gtgcgacaag    240

gagttcatgt gggccctgaa aaacggagac ttggatgagg tgaaagacta tgtggccaag    300

ggagaagatg tcaaccggac actagaaggt ggaaggaaac ctcttcatta tgcagcagat    360

tgtgggcagc ttgaaatcct ggaatttctg ctgctgaaag gagcagatat taatgctcca    420

gataaacatc atattactcc tcttctgtct gctgtctatg agggtcatgt ttcctgtgtg    480

aaattgcttc tgtcaaaggg tgctgataag actgtgaaag gcccagatgg actgaccgcc    540

tttgaagcca ctgacaacca ggcaatcaaa gctcttctcc agtgatggat ggatggactg    600

ataactccgg aagaatgact ctcctgtggc ctcacactgc tgcctgtctg tctgtcactc    660

tctatctgcc agcttcttca gctaaatact ttaagagggg tgaggggaga gagaaattca    720

taacaaatcc gactaccaga aaaaaaaaat tgttttggag gaggggcaaa aggaaccatg    780

atcaggcttt tactgggatt cctgatcaag taagcctctt ccctttctaa taaaatatac    840

accttatacc caagggagag caaagacaaa atacaccagt aacatttgac cttttcagct    900

ccctagctaa tttattagat tgtgttgaag gtctgattct acaaaggcca actctacata    960

tttggtagcc ctaactgtct gagcagtagt ggctgctgtg atgtaaactt agggtgctga   1020

gataagcaat tagctctagc cttctgcctt aagaatgcac tctactgggg atttcctggc   1080

atagttaaga gcgctgccta taaggttggt gaccaaatct ttcctcggtg actttaagct   1140

ttatgtgaaa gcttagttaa ggtgaggagg ggcacactcc taaattgctg gatgactgaa   1200

ctttggattt tctctcccct ttcacatgga tttcatgtct ctttagataa aactgactag   1260

ttttatttat aaaatcttaa gttttggaag tctaaaggag aaaccattcc agtatgcata   1320

tttttttctc ctctagattc atacatttat atagcattga aacactttca aactcctgct   1380

ggtagtaaaa ggggatttaa aaatagaatc atagccataa gcctgttagt atcatatgaa   1440

gagagaacag ttatcttagt acctatggat tttctttatt tgctgtttga atggattgac   1500

cttggttatg tgttgagaat taaggaacat tctttgaaat gcctctctca gacccatctt   1560

ggaggctgat tacttactgc accaaagcta tcactggggt gagatttact gtttggacaa   1620

atttagcccc atcccttcaa aaatacactt gtaaccaggt ttcccagagt tgttgatagg   1680

cttctgctga acatatgcca acccacctgc ataatatatt tttgttgctt ttataaatca   1740

tgcattacat aaagtgtgac aacttcaaaa tgtattctct gttcttggaa tacagtgccc   1800

taaaatggtg ttcttatgac ctgcagaaaa tatttacaca tatttccaaa tatttatttc   1860

atgagcagta cagctaatta aaatatataa gcttaaattt tatatcttac atttaaaata   1920

ttaagattcc tttgacttgc catccatata agcttgctaa aaatattaag accaagtcat   1980

gcaataattg aatgtacctc aaatttttag gggagggtgg gttagggact gatactcaga   2040

ttgtggataa taattgaatt ggtttttaaa ggcaacatag cattctacag cagggttaat   2100

ctattatcaa gaacagtcac cctggttaat aacaagtttt actgatcagt tgctggttgg   2160

ttggttggtt ggcatgtggg tgtgtgggtg tataggtgtg tgtgggtgtg tgtgtgtatt   2220

tttccccatg agtccttttt ttaatcctgt ggctttttca cttacaacta gcctaaccct   2280

gtaattttcc tacatccaag aaaacaatca caaagtagtg gtttaaatac tttgttgtat   2340

ttggctaatt ttgctgtctt aatgcagcct attaagagtt gggttaaaaa tcagtaatca   2400

gtactttatt acatcactga actaaaatat ggagacatcc tcattgaaaa tggagggcac   2460

tctatcagtc tataactatc aacgtagtgc aacagggtgt tttgatacct ttgttttcac   2520

ctcttgacat aatgctattt aaaggcttga atttttccct ttatataatt ttcaccttta   2580

ctttcaaagt gttttgttgt agttggctat tgcagagagt gcattgtcct atcattccta   2640

aacctggtct gctttctaca ttcatggtat ggaaaccatg tgattctttg tacagtttat   2700

cctgatgttg cttgtaatgc agtagaggct atttcgcctt cgcttttctt tctcgacctt   2760

tttgtaaacc ctataattat gaagcgattg cttgagaaaa taacatataa acatagaata   2820

gaatagactg accaagatgg ttcacagttt ctttttttaa ctaggttatt tataatgtat   2880

ttctgaacca cttggcagac aaattcacaa cacttaatgt tcatattttg agtaaaggaa   2940

gctaaaacca tgtttgcttt ctggtactac atgcattagc gaaaggttaa gtaagttttg   3000

ttctccactg aagtaatact taacatctca gaaaaaattt tgcatgttct gtagttttgt   3060

attaaatcag tcatttcata tgcactatat caagtacaaa caggtagttt acctgtttat   3120

agtagtgtac taacaaagtc tcccttgcag cttcagactg ttatctatag gcttatcgtt   3180

caaatacagc acttgaatat cccaagtagt tcttctacgc atagctcacc tttctaaacc   3240

cagttaagca tggaagagag gtagtaggta ggtgcagtgt gtggaagctg caaacaagta   3300

ggccttttat tcattgatat cttttcccaa gtactggatt ttaaatctgt atgtatctgt   3360

ttgatttttt tttctaatat ttcagttgag ctgctgtttt cttccatgca atattgtata   3420

ctcaattgtg tatagaagaa gctggtgaga gtgccctcct acataaataa gcaattgcag   3480

tgttttgcat gcaaaatata aaaaatttaa attgtcctga ttctattttg taaatggaga   3540

aacaatcata tctttctaag cggtaatgga ggaagactag tgctttgtgc attttgatat   3600

atttgagttc attttttcca caatgtcata cttttgacgc agttgggttt ctcataagta   3660

tcctagttca tgtacatccg aatgctaaat aatactgtgt tttaagtttt gtgttgcaag   3720

aacaaatgga ataaacttga attgtgctac gaaaaaaaaa aaaaaaaaaa              3770


<210>  2126
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  2126

Met Cys Asp Lys Glu Phe Met Trp Ala Leu Lys Asn Gly Asp Leu Asp 
1               5                   10                  15      


Glu Val Lys Asp Tyr Val Ala Lys Gly Glu Asp Val Asn Arg Thr Leu 
            20                  25                  30          


Glu Gly Gly Arg Lys Pro Leu His Tyr Ala Ala Asp Cys Gly Gln Leu 
        35                  40                  45              


Glu Ile Leu Glu Phe Leu Leu Leu Lys Gly Ala Asp Ile Asn Ala Pro 
    50                  55                  60                  


Asp Lys His His Ile Thr Pro Leu Leu Ser Ala Val Tyr Glu Gly His 
65                  70                  75                  80  


Val Ser Cys Val Lys Leu Leu Leu Ser Lys Gly Ala Asp Lys Thr Val 
                85                  90                  95      


Lys Gly Pro Asp Gly Leu Thr Ala Phe Glu Ala Thr Asp Asn Gln Ala 
            100                 105                 110         


Ile Lys Ala Leu Leu Gln 
        115             


<210>  2127
<211>  6513
<212>  DNA
<213>  Homosapiens

<400>  2127
attgctaagc catccttcag acagagaggg agcggctgca agaggtaatg agagatggca     60

agaaagaagc tgaaaaaatt tactactttg gagattgtgc tcagtgttct tctgcttgtg    120

ttgtttatca tcagtattgt tctaattgtg cttttagcca aagagtcact gaaatcaaca    180

gccccagatc ctgggacaac tggtaccccg gatcctggga caactggtac cccagatcct    240

ggaacaactg gtaccacaca tgctaggaca acgggtcccc cagatcctgg aacaactggt    300

accactcctg tttctgctga atgtccagtg gtaaatgaat tggaacgaat taattgcatc    360

cctgaccagc cgccaacaaa ggccacatgt gaccaacgtg gctgttgctg gaatccccag    420

ggagctgtaa gtgttccctg gtgctactat tccaagaatc atagctacca tgtagagggc    480

aaccttgtca acacaaatgc aggattcaca gcccggttga aaaatctgcc ttcctcacca    540

gtgtttggaa gcaatgttga caatgttctt ctcacagcag aatatcagac atctaatcgt    600

ttccacttta agttgactga ccaaaccaat aacaggtttg aagtgcccca cgaacacgtg    660

cagtccttca gtggaaatgc tgctgcttct ttgacctacc aagttgaaat ctccagacag    720

ccatttagca tcaaagtgac cagaagaagc aacaatcgtg ttttgtttga ctcgagcatt    780

gggcccctac tgtttgctga ccagttcttg cagctctcca ctcgactgcc tagcactaac    840

gtgtatggcc tgggagagca tgtgcaccag cagtatcggc atgatatgaa ttggaagacc    900

tggcccatat ttaacagaga cacaactccc aatggaaacg gaactaattt gtatggtgcg    960

cagacattct tcttgtgcct tgaagatgct agtggattgt cctttggggt gtttctgatg   1020

aacagcaatg ccatggaggt tgtccttcag cctgcgccag ccatcactta ccgcaccatt   1080

gggggcattc tcgacttcta tgtgttcttg ggaaacactc cagagcaagt tgttcaagaa   1140

tatctagagc tcattgggcg gccagccctt ccctcctact gggcgcttgg atttcacctc   1200

agtcgttacg aatatggaac cttagacaac atgagggaag tcgtggagag aaatcgcgca   1260

gcacagctcc cttatgatgt tcagcatgct gatattgatt atatggatga gagaagggac   1320

ttcacttatg attcagtgga ttttaaaggc ttccctgaat ttgtcaacga gttacacaat   1380

aatggacaga agcttgtcat cattgtggat ccagccatct ccaacaactc ttcctcaagt   1440

aaaccctatg gcccatatga caggggttcg gatatgaaga tatgggtgaa tagttcagat   1500

ggagtgactc cactcattgg ggaggtctgg cctggacaaa ctgtgtttcc tgattatacc   1560

aatcccaact gtgctgtttg gtggacaaag gaatttgagc tttttcacaa tcaagtagag   1620

tttgatggaa tctggattga tatgaatgaa gtctccaact ttgttgatgg ttcggtctca   1680

ggatgttcca caaacaacct aaataatccc ccattcactc ccagaatcct ggatgggtac   1740

ctgttctgca agactctctg tatggatgca gtgcagcact ggggcaagca gtatgacatt   1800

cacaatctgt atggctactc catggcggtc gccacagcag aagctgccaa gactgtgttc   1860

cctaataaga gaagcttcat tctgacccgt tctacctttg cgggctctgg caagtttgca   1920

gcacattggt taggagacaa cactgccacc tgggatgacc tgagatggtc catccctggc   1980

gtgcttgagt tcaacctttt tggcatccca atggtgggtc ctgacatatg tggctttgct   2040

ttggacaccc ctgaggagct ctgtaggcgg tggatgcagt tgggtgcatt ttatccgttt   2100

tctagaaatc acaatggcca aggctacaag gaccaggatc ctgcctcctt tggagctgac   2160

tccctgctgt tgaattcctc caggcactac cttaacatcc gctatactct attgccctac   2220

ctatacaccc ttttcttccg tgctcacagc cgaggggaca cggtggccag gccccttttg   2280

catgagttct acgaggacaa cagcacttgg gatgtgcacc aacagttctt atgggggccc   2340

ggcctcctca tcactccagt tctggatgaa ggtgcagaga aagcgatggc atatgtgcct   2400

gatgctgtct ggtatgacta cgagactggg agccaagtga gatggaggaa gcaaaaagtc   2460

gagatggaac ttcctggaga caaaattgga cttcaccttc gaggaggcta catcttcccc   2520

acacagcagc caaatacaac cactctggcc agtcgaaaga accctcttgg tcttatcatt   2580

gccctagatg agaacaaaga agcaaaagga gaacttttct gggatgatgg ggaaacgaag   2640

gatactgtgg ccaataaagt gtatctttta tgtgagtttt ctgtcactca aaaccgcttg   2700

gaggtgaata tttcacaatc aacctacaag gaccccaata atttagcatt taatgagatt   2760

aaaattcttg ggacggagga acctagcaat gttacagtga aacacaatgg tgtcccaagt   2820

cagacttctc ctacagtcac ttatgattct aacctgaagg ttgccattat cacagatatt   2880

gatcttctcc tgggagaagc atacacagtg gaatggagca taaagataag ggatgaagaa   2940

aaaatagact gttaccctga tgagaatggt gcttctgccg aaaactgcac tgcccgtggc   3000

tgtatctggg aggcatccaa ttcttctgga gtcccttttt gctattttgt caacgaccta   3060

tactctgtca gtgatgttca gtataattcc catggggcca cagctgacat ctccttaaag   3120

tcttccgttt atgccaatgc cttcccctcc acacccgtga acccccttcg cctggatgtc   3180

acttaccata agaatgaaat gccgcagttc aagatttatg atcccaacaa gaatcggtat   3240

gaagttccag tccctctgaa catacccagc atgccatcca gcacccctga gggtcaactc   3300

tatgatgtgc tcattaagaa gaatccattt gggattgaaa ttcgccggaa gagtataggc   3360

actataattt gggactctca gctccttggc tttaccttca gtgacatgtt tatccgcatc   3420

tccacccgcc ttccctccaa gtacctctat ggcttcgggg aaactgagca caggtcctat   3480

aggagagact tggagtggca cacttggggg atgttctccc gagaccagcc cccagggtac   3540

aagaagaatt cctatggtgt ccacccctac tacatggggc tggaggagga cggcagtgcc   3600

catggagtgc tcctgctgaa cagcaatgcc atggatgtga cgttccagcc cctgcctgcc   3660

ttgacatacc gcaccacagg gggagttctg gacttttatg tgttcttggg gccgactcca   3720

gagcttgtca cccagcagta cactgagttg attggccggc ctgtgatggt accttactgg   3780

tctttggggt tccagctgtg tcgctatggc taccagaatg actctgagat cgccagcttg   3840

tatgatgaga tggtggctgc ccagatccct tatgatgtgc agtactcaga catcgactac   3900

atggagcggc agctggactt caccctcagc cccaagtttg ctgggtttcc agctctgatc   3960

aatcgcatga aggctgatgg gatgcgggtc atcctcattc tggatccagc catttctggc   4020

aatgagacac agccttatcc tgccttcact cggggcgtgg aggatgacgt cttcatcaaa   4080

tacccaaatg atggagacat tgtctgggga aaggtctggc ctgattttcc tgatgttgtt   4140

gtgaatgggt ctctagactg ggacagccaa gtggagctat atcgagctta tgtggccttc   4200

ccagactttt tccgtaattc aactgccaag tggtggaaga gggaaataga agaactatac   4260

aacaatccac agaatccaga gaggagcttg aagtttgatg gcatgtggat tgatatgaat   4320

gaaccatcaa gcttcgtgaa tggggcagtt tctccaggct gcagggacgc ctctctgaac   4380

caccctccct acatgccaca tttggagtcc agggacaggg gcctgagcag caagaccctt   4440

tgtatggaga gtcagcagat cctcccagac ggctccctgg tgcagcacta caacgtgcac   4500

aacctgtatg ggtggtccca gaccagaccc acatacgaag ccgtgcagga ggtgacggga   4560

cagcgagggg tcgtcatcac ccgctccaca tttccctctt ctggccgctg ggcaggacat   4620

tggctgggag acaacacggc cgcatgggat cagctgaaga agtctatcat tggcatgacg   4680

gagttcagcc tcttcggcat atcctatacg ggagcagata tctgtgggtt ctttcaagat   4740

gctgaatatg agatgtgtgt tcgctggatg cagctggggg ccttttaccc cttctcaaga   4800

aaccacaaca ccattgggac caggagacaa gaccctgtgt cctgggatgt tgcttttgtg   4860

aatatttcca gaactgtcct gcagaccaga tgcaccctgt tgccatatct gtataccttg   4920

atgcataagg cccacacgga gggcgtcact gttgtgcggc ctctgctcca tgaatttgtg   4980

tcagaccagg tgacatggga catagacagt cagttcctgc tgggcccagc cttcctggtc   5040

agccctgtcc tggagcgtaa tgccagaaat gtcactgcat atttccctag agcccgctgg   5100

tatgattact acacgggtgt ggatattaat gcaagaggag agtggaagac cttgccagcc   5160

cctcttgacc acattaatct tcatgtccgt gggggctaca tcctgccctg gcaagagcct   5220

gcactgaaca cccacttaag ccgccagaaa ttcatgggct tcaaaattgc cttggatgat   5280

gaaggaactg ctgggggctg gctcttctgg gatgatgggc aaagcattga tacctatggg   5340

aaaggactct attacttggc cagcttttct gccagccaga atacgatgca aagccatata   5400

attttcaaca attacatcac tggtacaaat cctttgaaac tgggctacat tgaaatctgg   5460

ggagtgggca gtgtccccgt taccagtgcc agcatctctg tgagtggcat ggtcataaca   5520

ccctccttca acaatgaccc cacgacacag gtattaagca tcgatgtgac tgacagaaac   5580

atcagcctac ataattttac ttcattgacg tggataagca ctctgtgaat ttttacagca   5640

agattctaac taactatgaa tgactttgaa actacttata cttcatactc ataaaaatta   5700

ttgtgtgttg ctaatttgtt catacccact attggtgaaa tatttctgtt aattttgtta   5760

tatgtttttt gtgtgaaccc taaaggttaa accttagccc tgtgggatag gcagttaggg   5820

aggtgtggaa aatctatgca ttaccttaat gtctctgtgt ggttagtatg gtagtgactg   5880

ttcatcatat gacatttact gaagatgaac tgggtccatg atgaagtgtg tgtatgtcca   5940

cgtttgtaat catagaatgg accccattct tttgttaaat acacaagaga aagctttctg   6000

tgacagttcc aggtcttgaa gctaatcagc atctcaagaa agtatccaga aagaacatct   6060

gctagttggt tataggcggt gggaggaata atatacctaa ttggttatag gtggggggag   6120

catgataagc aaagaaaagg caaacacaag gaaagatcag atgaaacaga agatgatagt   6180

aaaagtgatc ctaagtaaga acataatgta aaattgtcag cagcctcatg gggaggaaaa   6240

aggaagagtc aactcacttg aagaagaggg tcttgagaaa tccttagcat aaagggctac   6300

tggtgagatt gagatctgag caggcaaagc tcaaaagaga gtttggaggt taaaaataat   6360

ttatttttgc agtagtgtgc tttgaaatgt gtaaatctta tttctaatgt atacaaccac   6420

atttcacata aaaatatgca atttatatgc cagataaaaa taaaacaagt gaatttgcaa   6480

gtgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                6513


<210>  2128
<211>  1857
<212>  PRT
<213>  Homosapiens

<400>  2128

Met Ala Arg Lys Lys Leu Lys Lys Phe Thr Thr Leu Glu Ile Val Leu 
1               5                   10                  15      


Ser Val Leu Leu Leu Val Leu Phe Ile Ile Ser Ile Val Leu Ile Val 
            20                  25                  30          


Leu Leu Ala Lys Glu Ser Leu Lys Ser Thr Ala Pro Asp Pro Gly Thr 
        35                  40                  45              


Thr Gly Thr Pro Asp Pro Gly Thr Thr Gly Thr Pro Asp Pro Gly Thr 
    50                  55                  60                  


Thr Gly Thr Thr His Ala Arg Thr Thr Gly Pro Pro Asp Pro Gly Thr 
65                  70                  75                  80  


Thr Gly Thr Thr Pro Val Ser Ala Glu Cys Pro Val Val Asn Glu Leu 
                85                  90                  95      


Glu Arg Ile Asn Cys Ile Pro Asp Gln Pro Pro Thr Lys Ala Thr Cys 
            100                 105                 110         


Asp Gln Arg Gly Cys Cys Trp Asn Pro Gln Gly Ala Val Ser Val Pro 
        115                 120                 125             


Trp Cys Tyr Tyr Ser Lys Asn His Ser Tyr His Val Glu Gly Asn Leu 
    130                 135                 140                 


Val Asn Thr Asn Ala Gly Phe Thr Ala Arg Leu Lys Asn Leu Pro Ser 
145                 150                 155                 160 


Ser Pro Val Phe Gly Ser Asn Val Asp Asn Val Leu Leu Thr Ala Glu 
                165                 170                 175     


Tyr Gln Thr Ser Asn Arg Phe His Phe Lys Leu Thr Asp Gln Thr Asn 
            180                 185                 190         


Asn Arg Phe Glu Val Pro His Glu His Val Gln Ser Phe Ser Gly Asn 
        195                 200                 205             


Ala Ala Ala Ser Leu Thr Tyr Gln Val Glu Ile Ser Arg Gln Pro Phe 
    210                 215                 220                 


Ser Ile Lys Val Thr Arg Arg Ser Asn Asn Arg Val Leu Phe Asp Ser 
225                 230                 235                 240 


Ser Ile Gly Pro Leu Leu Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr 
                245                 250                 255     


Arg Leu Pro Ser Thr Asn Val Tyr Gly Leu Gly Glu His Val His Gln 
            260                 265                 270         


Gln Tyr Arg His Asp Met Asn Trp Lys Thr Trp Pro Ile Phe Asn Arg 
        275                 280                 285             


Asp Thr Thr Pro Asn Gly Asn Gly Thr Asn Leu Tyr Gly Ala Gln Thr 
    290                 295                 300                 


Phe Phe Leu Cys Leu Glu Asp Ala Ser Gly Leu Ser Phe Gly Val Phe 
305                 310                 315                 320 


Leu Met Asn Ser Asn Ala Met Glu Val Val Leu Gln Pro Ala Pro Ala 
                325                 330                 335     


Ile Thr Tyr Arg Thr Ile Gly Gly Ile Leu Asp Phe Tyr Val Phe Leu 
            340                 345                 350         


Gly Asn Thr Pro Glu Gln Val Val Gln Glu Tyr Leu Glu Leu Ile Gly 
        355                 360                 365             


Arg Pro Ala Leu Pro Ser Tyr Trp Ala Leu Gly Phe His Leu Ser Arg 
    370                 375                 380                 


Tyr Glu Tyr Gly Thr Leu Asp Asn Met Arg Glu Val Val Glu Arg Asn 
385                 390                 395                 400 


Arg Ala Ala Gln Leu Pro Tyr Asp Val Gln His Ala Asp Ile Asp Tyr 
                405                 410                 415     


Met Asp Glu Arg Arg Asp Phe Thr Tyr Asp Ser Val Asp Phe Lys Gly 
            420                 425                 430         


Phe Pro Glu Phe Val Asn Glu Leu His Asn Asn Gly Gln Lys Leu Val 
        435                 440                 445             


Ile Ile Val Asp Pro Ala Ile Ser Asn Asn Ser Ser Ser Ser Lys Pro 
    450                 455                 460                 


Tyr Gly Pro Tyr Asp Arg Gly Ser Asp Met Lys Ile Trp Val Asn Ser 
465                 470                 475                 480 


Ser Asp Gly Val Thr Pro Leu Ile Gly Glu Val Trp Pro Gly Gln Thr 
                485                 490                 495     


Val Phe Pro Asp Tyr Thr Asn Pro Asn Cys Ala Val Trp Trp Thr Lys 
            500                 505                 510         


Glu Phe Glu Leu Phe His Asn Gln Val Glu Phe Asp Gly Ile Trp Ile 
        515                 520                 525             


Asp Met Asn Glu Val Ser Asn Phe Val Asp Gly Ser Val Ser Gly Cys 
    530                 535                 540                 


Ser Thr Asn Asn Leu Asn Asn Pro Pro Phe Thr Pro Arg Ile Leu Asp 
545                 550                 555                 560 


Gly Tyr Leu Phe Cys Lys Thr Leu Cys Met Asp Ala Val Gln His Trp 
                565                 570                 575     


Gly Lys Gln Tyr Asp Ile His Asn Leu Tyr Gly Tyr Ser Met Ala Val 
            580                 585                 590         


Ala Thr Ala Glu Ala Ala Lys Thr Val Phe Pro Asn Lys Arg Ser Phe 
        595                 600                 605             


Ile Leu Thr Arg Ser Thr Phe Ala Gly Ser Gly Lys Phe Ala Ala His 
    610                 615                 620                 


Trp Leu Gly Asp Asn Thr Ala Thr Trp Asp Asp Leu Arg Trp Ser Ile 
625                 630                 635                 640 


Pro Gly Val Leu Glu Phe Asn Leu Phe Gly Ile Pro Met Val Gly Pro 
                645                 650                 655     


Asp Ile Cys Gly Phe Ala Leu Asp Thr Pro Glu Glu Leu Cys Arg Arg 
            660                 665                 670         


Trp Met Gln Leu Gly Ala Phe Tyr Pro Phe Ser Arg Asn His Asn Gly 
        675                 680                 685             


Gln Gly Tyr Lys Asp Gln Asp Pro Ala Ser Phe Gly Ala Asp Ser Leu 
    690                 695                 700                 


Leu Leu Asn Ser Ser Arg His Tyr Leu Asn Ile Arg Tyr Thr Leu Leu 
705                 710                 715                 720 


Pro Tyr Leu Tyr Thr Leu Phe Phe Arg Ala His Ser Arg Gly Asp Thr 
                725                 730                 735     


Val Ala Arg Pro Leu Leu His Glu Phe Tyr Glu Asp Asn Ser Thr Trp 
            740                 745                 750         


Asp Val His Gln Gln Phe Leu Trp Gly Pro Gly Leu Leu Ile Thr Pro 
        755                 760                 765             


Val Leu Asp Glu Gly Ala Glu Lys Ala Met Ala Tyr Val Pro Asp Ala 
    770                 775                 780                 


Val Trp Tyr Asp Tyr Glu Thr Gly Ser Gln Val Arg Trp Arg Lys Gln 
785                 790                 795                 800 


Lys Val Glu Met Glu Leu Pro Gly Asp Lys Ile Gly Leu His Leu Arg 
                805                 810                 815     


Gly Gly Tyr Ile Phe Pro Thr Gln Gln Pro Asn Thr Thr Thr Leu Ala 
            820                 825                 830         


Ser Arg Lys Asn Pro Leu Gly Leu Ile Ile Ala Leu Asp Glu Asn Lys 
        835                 840                 845             


Glu Ala Lys Gly Glu Leu Phe Trp Asp Asp Gly Glu Thr Lys Asp Thr 
    850                 855                 860                 


Val Ala Asn Lys Val Tyr Leu Leu Cys Glu Phe Ser Val Thr Gln Asn 
865                 870                 875                 880 


Arg Leu Glu Val Asn Ile Ser Gln Ser Thr Tyr Lys Asp Pro Asn Asn 
                885                 890                 895     


Leu Ala Phe Asn Glu Ile Lys Ile Leu Gly Thr Glu Glu Pro Ser Asn 
            900                 905                 910         


Val Thr Val Lys His Asn Gly Val Pro Ser Gln Thr Ser Pro Thr Val 
        915                 920                 925             


Thr Tyr Asp Ser Asn Leu Lys Val Ala Ile Ile Thr Asp Ile Asp Leu 
    930                 935                 940                 


Leu Leu Gly Glu Ala Tyr Thr Val Glu Trp Ser Ile Lys Ile Arg Asp 
945                 950                 955                 960 


Glu Glu Lys Ile Asp Cys Tyr Pro Asp Glu Asn Gly Ala Ser Ala Glu 
                965                 970                 975     


Asn Cys Thr Ala Arg Gly Cys Ile Trp Glu Ala Ser Asn Ser Ser Gly 
            980                 985                 990         


Val Pro Phe Cys Tyr Phe Val Asn  Asp Leu Tyr Ser Val  Ser Asp Val 
        995                 1000                 1005             


Gln Tyr  Asn Ser His Gly Ala  Thr Ala Asp Ile Ser  Leu Lys Ser 
    1010                 1015                 1020             


Ser Val  Tyr Ala Asn Ala Phe  Pro Ser Thr Pro Val  Asn Pro Leu 
    1025                 1030                 1035             


Arg Leu  Asp Val Thr Tyr His  Lys Asn Glu Met Pro  Gln Phe Lys 
    1040                 1045                 1050             


Ile Tyr  Asp Pro Asn Lys Asn  Arg Tyr Glu Val Pro  Val Pro Leu 
    1055                 1060                 1065             


Asn Ile  Pro Ser Met Pro Ser  Ser Thr Pro Glu Gly  Gln Leu Tyr 
    1070                 1075                 1080             


Asp Val  Leu Ile Lys Lys Asn  Pro Phe Gly Ile Glu  Ile Arg Arg 
    1085                 1090                 1095             


Lys Ser  Ile Gly Thr Ile Ile  Trp Asp Ser Gln Leu  Leu Gly Phe 
    1100                 1105                 1110             


Thr Phe  Ser Asp Met Phe Ile  Arg Ile Ser Thr Arg  Leu Pro Ser 
    1115                 1120                 1125             


Lys Tyr  Leu Tyr Gly Phe Gly  Glu Thr Glu His Arg  Ser Tyr Arg 
    1130                 1135                 1140             


Arg Asp  Leu Glu Trp His Thr  Trp Gly Met Phe Ser  Arg Asp Gln 
    1145                 1150                 1155             


Pro Pro  Gly Tyr Lys Lys Asn  Ser Tyr Gly Val His  Pro Tyr Tyr 
    1160                 1165                 1170             


Met Gly  Leu Glu Glu Asp Gly  Ser Ala His Gly Val  Leu Leu Leu 
    1175                 1180                 1185             


Asn Ser  Asn Ala Met Asp Val  Thr Phe Gln Pro Leu  Pro Ala Leu 
    1190                 1195                 1200             


Thr Tyr  Arg Thr Thr Gly Gly  Val Leu Asp Phe Tyr  Val Phe Leu 
    1205                 1210                 1215             


Gly Pro  Thr Pro Glu Leu Val  Thr Gln Gln Tyr Thr  Glu Leu Ile 
    1220                 1225                 1230             


Gly Arg  Pro Val Met Val Pro  Tyr Trp Ser Leu Gly  Phe Gln Leu 
    1235                 1240                 1245             


Cys Arg  Tyr Gly Tyr Gln Asn  Asp Ser Glu Ile Ala  Ser Leu Tyr 
    1250                 1255                 1260             


Asp Glu  Met Val Ala Ala Gln  Ile Pro Tyr Asp Val  Gln Tyr Ser 
    1265                 1270                 1275             


Asp Ile  Asp Tyr Met Glu Arg  Gln Leu Asp Phe Thr  Leu Ser Pro 
    1280                 1285                 1290             


Lys Phe  Ala Gly Phe Pro Ala  Leu Ile Asn Arg Met  Lys Ala Asp 
    1295                 1300                 1305             


Gly Met  Arg Val Ile Leu Ile  Leu Asp Pro Ala Ile  Ser Gly Asn 
    1310                 1315                 1320             


Glu Thr  Gln Pro Tyr Pro Ala  Phe Thr Arg Gly Val  Glu Asp Asp 
    1325                 1330                 1335             


Val Phe  Ile Lys Tyr Pro Asn  Asp Gly Asp Ile Val  Trp Gly Lys 
    1340                 1345                 1350             


Val Trp  Pro Asp Phe Pro Asp  Val Val Val Asn Gly  Ser Leu Asp 
    1355                 1360                 1365             


Trp Asp  Ser Gln Val Glu Leu  Tyr Arg Ala Tyr Val  Ala Phe Pro 
    1370                 1375                 1380             


Asp Phe  Phe Arg Asn Ser Thr  Ala Lys Trp Trp Lys  Arg Glu Ile 
    1385                 1390                 1395             


Glu Glu  Leu Tyr Asn Asn Pro  Gln Asn Pro Glu Arg  Ser Leu Lys 
    1400                 1405                 1410             


Phe Asp  Gly Met Trp Ile Asp  Met Asn Glu Pro Ser  Ser Phe Val 
    1415                 1420                 1425             


Asn Gly  Ala Val Ser Pro Gly  Cys Arg Asp Ala Ser  Leu Asn His 
    1430                 1435                 1440             


Pro Pro  Tyr Met Pro His Leu  Glu Ser Arg Asp Arg  Gly Leu Ser 
    1445                 1450                 1455             


Ser Lys  Thr Leu Cys Met Glu  Ser Gln Gln Ile Leu  Pro Asp Gly 
    1460                 1465                 1470             


Ser Leu  Val Gln His Tyr Asn  Val His Asn Leu Tyr  Gly Trp Ser 
    1475                 1480                 1485             


Gln Thr  Arg Pro Thr Tyr Glu  Ala Val Gln Glu Val  Thr Gly Gln 
    1490                 1495                 1500             


Arg Gly  Val Val Ile Thr Arg  Ser Thr Phe Pro Ser  Ser Gly Arg 
    1505                 1510                 1515             


Trp Ala  Gly His Trp Leu Gly  Asp Asn Thr Ala Ala  Trp Asp Gln 
    1520                 1525                 1530             


Leu Lys  Lys Ser Ile Ile Gly  Met Thr Glu Phe Ser  Leu Phe Gly 
    1535                 1540                 1545             


Ile Ser  Tyr Thr Gly Ala Asp  Ile Cys Gly Phe Phe  Gln Asp Ala 
    1550                 1555                 1560             


Glu Tyr  Glu Met Cys Val Arg  Trp Met Gln Leu Gly  Ala Phe Tyr 
    1565                 1570                 1575             


Pro Phe  Ser Arg Asn His Asn  Thr Ile Gly Thr Arg  Arg Gln Asp 
    1580                 1585                 1590             


Pro Val  Ser Trp Asp Val Ala  Phe Val Asn Ile Ser  Arg Thr Val 
    1595                 1600                 1605             


Leu Gln  Thr Arg Cys Thr Leu  Leu Pro Tyr Leu Tyr  Thr Leu Met 
    1610                 1615                 1620             


His Lys  Ala His Thr Glu Gly  Val Thr Val Val Arg  Pro Leu Leu 
    1625                 1630                 1635             


His Glu  Phe Val Ser Asp Gln  Val Thr Trp Asp Ile  Asp Ser Gln 
    1640                 1645                 1650             


Phe Leu  Leu Gly Pro Ala Phe  Leu Val Ser Pro Val  Leu Glu Arg 
    1655                 1660                 1665             


Asn Ala  Arg Asn Val Thr Ala  Tyr Phe Pro Arg Ala  Arg Trp Tyr 
    1670                 1675                 1680             


Asp Tyr  Tyr Thr Gly Val Asp  Ile Asn Ala Arg Gly  Glu Trp Lys 
    1685                 1690                 1695             


Thr Leu  Pro Ala Pro Leu Asp  His Ile Asn Leu His  Val Arg Gly 
    1700                 1705                 1710             


Gly Tyr  Ile Leu Pro Trp Gln  Glu Pro Ala Leu Asn  Thr His Leu 
    1715                 1720                 1725             


Ser Arg  Gln Lys Phe Met Gly  Phe Lys Ile Ala Leu  Asp Asp Glu 
    1730                 1735                 1740             


Gly Thr  Ala Gly Gly Trp Leu  Phe Trp Asp Asp Gly  Gln Ser Ile 
    1745                 1750                 1755             


Asp Thr  Tyr Gly Lys Gly Leu  Tyr Tyr Leu Ala Ser  Phe Ser Ala 
    1760                 1765                 1770             


Ser Gln  Asn Thr Met Gln Ser  His Ile Ile Phe Asn  Asn Tyr Ile 
    1775                 1780                 1785             


Thr Gly  Thr Asn Pro Leu Lys  Leu Gly Tyr Ile Glu  Ile Trp Gly 
    1790                 1795                 1800             


Val Gly  Ser Val Pro Val Thr  Ser Ala Ser Ile Ser  Val Ser Gly 
    1805                 1810                 1815             


Met Val  Ile Thr Pro Ser Phe  Asn Asn Asp Pro Thr  Thr Gln Val 
    1820                 1825                 1830             


Leu Ser  Ile Asp Val Thr Asp  Arg Asn Ile Ser Leu  His Asn Phe 
    1835                 1840                 1845             


Thr Ser  Leu Thr Trp Ile Ser  Thr Leu 
    1850                 1855         


<210>  2129
<211>  932
<212>  DNA
<213>  Homosapiens

<400>  2129
caaaaaggag accagacagg aggcgtctgt agagatatca tgaacttcaa cttagctttg     60

ttttccagag actggagcta aactgggctt tcaacatcat catgaagttt atcctcctct    120

gggccctctt gaatctgact gttgctttgg cctttaatcc agattacaca gtcagctcca    180

ctccccctta cttggtctat ttgaaatctg actacttgcc ctgcgctgga gtcctgatcc    240

acccgctttg ggtgatcaca gctgcacact gcaatttacc aaagcttcgg gtgatattgg    300

gggttacaat cccagcagac tctaatgaaa agcatctgca agtgattggc tatgagaaga    360

tgattcatca tccacacttc tcagtcactt ctattgatca tgacatcatg ctaatcaagc    420

tgaaaacaga ggctgaactc aatgactatg tgaaattagc caacctgccc taccaaacta    480

tctctgaaaa taccatgtgc tctgtctcta cctggagcta caatgtgtgt gatatctaca    540

aagagcccga ttcactgcaa actgtgaaca tctctgtaat ctccaagcct cagtgtcgcg    600

atgcctataa aacctacaac atcacggaaa atatgctgtg tgtgggcatt gtgccaggaa    660

ggaggcagcc ctgcaaggaa gtttctgctg ccccggcaat ctgcaatggg atgcttcaag    720

gaatcctgtc ttttgcggat ggatgtgttt tgagagccga tgttggcatc tatgccaaaa    780

ttttttacta tataccctgg attgaaaatg taatccaaaa taactgagct gtggcagttg    840

tggaccatat gacacagctt gtccccatcg ttcaccttta gaattaaata taaattaact    900

cctcaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                  932


<210>  2130
<211>  241
<212>  PRT
<213>  Homosapiens

<400>  2130

Met Lys Phe Ile Leu Leu Trp Ala Leu Leu Asn Leu Thr Val Ala Leu 
1               5                   10                  15      


Ala Phe Asn Pro Asp Tyr Thr Val Ser Ser Thr Pro Pro Tyr Leu Val 
            20                  25                  30          


Tyr Leu Lys Ser Asp Tyr Leu Pro Cys Ala Gly Val Leu Ile His Pro 
        35                  40                  45              


Leu Trp Val Ile Thr Ala Ala His Cys Asn Leu Pro Lys Leu Arg Val 
    50                  55                  60                  


Ile Leu Gly Val Thr Ile Pro Ala Asp Ser Asn Glu Lys His Leu Gln 
65                  70                  75                  80  


Val Ile Gly Tyr Glu Lys Met Ile His His Pro His Phe Ser Val Thr 
                85                  90                  95      


Ser Ile Asp His Asp Ile Met Leu Ile Lys Leu Lys Thr Glu Ala Glu 
            100                 105                 110         


Leu Asn Asp Tyr Val Lys Leu Ala Asn Leu Pro Tyr Gln Thr Ile Ser 
        115                 120                 125             


Glu Asn Thr Met Cys Ser Val Ser Thr Trp Ser Tyr Asn Val Cys Asp 
    130                 135                 140                 


Ile Tyr Lys Glu Pro Asp Ser Leu Gln Thr Val Asn Ile Ser Val Ile 
145                 150                 155                 160 


Ser Lys Pro Gln Cys Arg Asp Ala Tyr Lys Thr Tyr Asn Ile Thr Glu 
                165                 170                 175     


Asn Met Leu Cys Val Gly Ile Val Pro Gly Arg Arg Gln Pro Cys Lys 
            180                 185                 190         


Glu Val Ser Ala Ala Pro Ala Ile Cys Asn Gly Met Leu Gln Gly Ile 
        195                 200                 205             


Leu Ser Phe Ala Asp Gly Cys Val Leu Arg Ala Asp Val Gly Ile Tyr 
    210                 215                 220                 


Ala Lys Ile Phe Tyr Tyr Ile Pro Trp Ile Glu Asn Val Ile Gln Asn 
225                 230                 235                 240 


Asn 
    


<210>  2131
<211>  972
<212>  DNA
<213>  Homosapiens

<400>  2131
atggcaacgg tgaacacaga tgccacagat aaagacatat ccaagttcaa ggtcaccttc     60

actttggtgg tctccggaat agagtgcatc actggcatcc ttgggagtgg cttcatcacg    120

gccatctatg gggctgagtg ggccaggggc aaaacactcc ccactggtga ccgcattatg    180

ttgatgctga gcttttccag gctcttgcta cagatttgga tgatgctgga gaacattttc    240

agtctgctat tccgaattgt ttataaccaa aactcagtgt atatcctctt caaagtcatc    300

actgtctttc tgaaccattc caatctctgg tttgctgcct ggctcaaagt cttctattgt    360

cttagaattg caaacttcaa tcatcctttg ttcttcctga tgaagaggaa aatcatagtg    420

ctgatgcctt ggcttctcag gctgtcagtg ttggtttcct taagcttcag ctttcctctc    480

tcgagagatg tcttcaatgt gtatgtgaat agctccattc ctatcccctc ctccaactcc    540

acggagaaga agtacttctc tgagaccaat atggtcaacc tggtattttt ctataacatg    600

gggatcttcg ttcctctgat catgttcatc ctggcagcca ccctgctgat cctctctctc    660

aagagacaca ccctacacat gggaagcaat gccacagggt ccagggaccc cagcatgaag    720

gctcacatag gggccatcaa agccaccagc tactttctca tcctctacat tttcaatgca    780

attgctctat ttctttccac gtccaacatc tttgacactt acagttcctg gaatattttg    840

tgcaagatca tcatggctgc ctaccctgcc ggccactcag tacaactgat cttgggcaac    900

cctgggctga gaagagcctg gaagcggttt cagcaccaag ttcctcttta cctaaaaggg    960

cagactctgt ga                                                        972


<210>  2132
<211>  323
<212>  PRT
<213>  Homosapiens

<400>  2132

Met Ala Thr Val Asn Thr Asp Ala Thr Asp Lys Asp Ile Ser Lys Phe 
1               5                   10                  15      


Lys Val Thr Phe Thr Leu Val Val Ser Gly Ile Glu Cys Ile Thr Gly 
            20                  25                  30          


Ile Leu Gly Ser Gly Phe Ile Thr Ala Ile Tyr Gly Ala Glu Trp Ala 
        35                  40                  45              


Arg Gly Lys Thr Leu Pro Thr Gly Asp Arg Ile Met Leu Met Leu Ser 
    50                  55                  60                  


Phe Ser Arg Leu Leu Leu Gln Ile Trp Met Met Leu Glu Asn Ile Phe 
65                  70                  75                  80  


Ser Leu Leu Phe Arg Ile Val Tyr Asn Gln Asn Ser Val Tyr Ile Leu 
                85                  90                  95      


Phe Lys Val Ile Thr Val Phe Leu Asn His Ser Asn Leu Trp Phe Ala 
            100                 105                 110         


Ala Trp Leu Lys Val Phe Tyr Cys Leu Arg Ile Ala Asn Phe Asn His 
        115                 120                 125             


Pro Leu Phe Phe Leu Met Lys Arg Lys Ile Ile Val Leu Met Pro Trp 
    130                 135                 140                 


Leu Leu Arg Leu Ser Val Leu Val Ser Leu Ser Phe Ser Phe Pro Leu 
145                 150                 155                 160 


Ser Arg Asp Val Phe Asn Val Tyr Val Asn Ser Ser Ile Pro Ile Pro 
                165                 170                 175     


Ser Ser Asn Ser Thr Glu Lys Lys Tyr Phe Ser Glu Thr Asn Met Val 
            180                 185                 190         


Asn Leu Val Phe Phe Tyr Asn Met Gly Ile Phe Val Pro Leu Ile Met 
        195                 200                 205             


Phe Ile Leu Ala Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr 
    210                 215                 220                 


Leu His Met Gly Ser Asn Ala Thr Gly Ser Arg Asp Pro Ser Met Lys 
225                 230                 235                 240 


Ala His Ile Gly Ala Ile Lys Ala Thr Ser Tyr Phe Leu Ile Leu Tyr 
                245                 250                 255     


Ile Phe Asn Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp 
            260                 265                 270         


Thr Tyr Ser Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr 
        275                 280                 285             


Pro Ala Gly His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg 
    290                 295                 300                 


Arg Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly 
305                 310                 315                 320 


Gln Thr Leu 
            


<210>  2133
<211>  1017
<212>  DNA
<213>  Homosapiens

<400>  2133
gaaaaggagc tcctgctgcc actgctcttc cggagcctgc agcatggggc ccctgccgcg     60

caccgtggag ctcttctatg acgtgctgtc cccctactcc tggctgggct tcgagatcct    120

gtgccggtat cagaatatct ggaacatcaa cctgcagttg cggcccagcc tcataacagg    180

gatcatgaaa gacagtggaa acaagcctcc aggtctgctt ccccgcaaag gactatacat    240

ggcaaatgac ttaaagctcc tgagacacca tctccagatt cccatccact tccccaagga    300

tttcttgtct gtgatgcttg aaaaaggaag tttgtctgcc atgcgtttcc tcaccgccgt    360

gaacttggag catccagaga tgctggagaa agcgtcccgg gagctgtgga tgcgcgtctg    420

gtcaaggaat gaagacatca ccgagccgca gagcatcctg gcggctgcag agaaggctgg    480

tatgtctgca gaacaagccc agggacttct ggaaaagatc gcaacgccaa aggtgaagaa    540

ccagctcaag gagaccactg aggcagcctg cagatacgga gcctttgggt tgcccatcac    600

cgtggcccat gtggatggcc aaacccacat gttatttggc tctgaccgga tggagctgct    660

ggcgcacctg ctgggagaga agtggatggg ccctatacct ccagccgtga atgccagact    720

ttaagattgc ccggaggaag caaactcttc gtataaaaaa agcaggccat ctgcttaacc    780

cttggctcca ccataaggca ctgggactcg gatttctcta tctgatagag gtattttctg    840

tggccctggg agctgtctgt ctttccccta cccccaagga tgccaggaag acgtccacca    900

ttagccatgt ggcaaccttt acttctatgc ctcacaagtg cctttcagag agccccaatt    960

ctgctttccc acaaaataaa cctaatgcca tcaggcaaaa aaaaaaaaaa aaaaaaa      1017


<210>  2134
<211>  226
<212>  PRT
<213>  Homosapiens

<400>  2134

Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser 
1               5                   10                  15      


Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile 
            20                  25                  30          


Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met 
        35                  40                  45              


Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu 
    50                  55                  60                  


Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile Pro 
65                  70                  75                  80  


Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser 
                85                  90                  95      


Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu 
            100                 105                 110         


Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg 
        115                 120                 125             


Asn Glu Asp Ile Thr Glu Pro Gln Ser Ile Leu Ala Ala Ala Glu Lys 
    130                 135                 140                 


Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu Leu Glu Lys Ile Ala 
145                 150                 155                 160 


Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr Thr Glu Ala Ala Cys 
                165                 170                 175     


Arg Tyr Gly Ala Phe Gly Leu Pro Ile Thr Val Ala His Val Asp Gly 
            180                 185                 190         


Gln Thr His Met Leu Phe Gly Ser Asp Arg Met Glu Leu Leu Ala His 
        195                 200                 205             


Leu Leu Gly Glu Lys Trp Met Gly Pro Ile Pro Pro Ala Val Asn Ala 
    210                 215                 220                 


Arg Leu 
225     


<210>  2135
<211>  2400
<212>  DNA
<213>  Homosapiens

<400>  2135
gacaggtgag cgacgaactt ctgagacagg tgtgggtgcg agggtcggga gggtcatggg     60

attgggaccg aggtgtgagg agggaatctg caattccttg ctacacagag cgctggcaac    120

ttctgacagg ctgtttctgg ggtatgggct gcctcgggtt gttgctgtta caaggaaaga    180

aaagagttcc cctgcccacc gcctcccagc cactgggcta cctcctggca ggaaatttgc    240

aaactgagtt taacaagtta ggatcagcag agggtagagg agggccctgg cagatgtggg    300

gtctagaaga ggacaggagt tatcagggcc tccggccatt gtgctgggcc tttgcctgta    360

caattgtttc tcaagcagtt gtgtccctgt ggctttggtg cgcctgtgtg cactttctcc    420

ctccacctgg agcatgggct aacaccggag gaaaggaaaa gacagagtca gacagggagc    480

ctggggaggg gccatggtgc caatgcactt actggggaga ctggagaagc cgcttctcct    540

cctgtgctgc gcctccttcc tactggggct ggctttgctg ggcataaaga cggacatcac    600

ccccgttgct tatttctttc tcacattggg tggcttcttc ttgtttgcct atctcctggt    660

ccggtttctg gaatgggggc ttcggtccca gctccaatca atgcagactg agagcccagg    720

gccctcaggc aatgcacggg acaatgaagc ctttgaagtg ccagtctatg aagaggccgt    780

ggtgggacta gaatcccagt gccgccccca agagttggac caaccacccc cctacagcac    840

tgttgtgata cccccagcac ctgaggagga acaacctagc catccagagg ggtccaggag    900

agccaaactg gaacagaggc gaatggcctc agaggggtcc atggcccagg aaggaagccc    960

tggaagagct ccaatcaacc ttcggcttcg gggaccacgg gctgtgtcca ctgctcctga   1020

tctgcagagc ttggcggcag tccccacatt agagcctctg actccacccc ctgcctatga   1080

tgtctgcttt ggtcaccctg atgatgatag tgttttttat gaggacaact gggcaccccc   1140

ttaaatgact ctcccaagat ttctcttctc tccacaccag acctcgttca tttgactaac   1200

attttccagc gcctactatg tgtcagaaac aagtgtttct gcctggacat cataaatggg   1260

gacttggacc ctgaggagag tcaggccacg gtaagccctt cccagctgag atatgggtgg   1320

cataatttga gtcttctggc aacatttggt gacctacccc atatccaata tttccagcgt   1380

tagattgagg atgaggtagg gaggtgatcc agagaaggcg gagaaggaag aagtaacctc   1440

tgagtggcgg ctattgcttc tgttccaggt gctgttcgag ctgttagaac ccttaggctt   1500

gacagctttg tgagttatta ttgaaaaatg aggattccaa gagtcagagg agtttgataa   1560

tgtgcacgag ggcacactgc tagtaaataa cattaaaata actggaatga actcctgatc   1620

ccaaagccta ttgtgttttc aacacaaggt aataggaagc caagcaactt gcatgtctcc   1680

caatccctgt ctagggacag ctgctggtgc aggatggaag acttcctata aacagaatgg   1740

gcgaccaatt gtgtctacag agggggtggg ctgagcatgg gcacgcatgt ccccagcctc   1800

ctggacgagc aaagtcagtc aaagcgctgg tgatccctgc tccgcgtgcg tagcagtgtc   1860

tgtgcctctc ctgcccaggg gctagagagc agtctccagt gcagggtccc catcctatct   1920

gaaaacagtg gagtcagtga ccccaggtgg agggacttcc agttttaaca atgggttggt   1980

atgaaggcca gaaggagtga aacatgtgaa ctttctggcg aggagactcc ctcttgaatc   2040

atccatatgt agccccgggg tcacttgcga agagtctcta acagcttctg cctcactcct   2100

aagctctgac cgctaggctt tcaccccagc cgccggtcct gattcctgag atcccaatat   2160

tgagcaccag gtttcctgga attgtgtgct gcggctgtga tgtaggtttc ggtcgctgga   2220

agctgctaaa ccatagctga cgccccctcc taagccagcc ttccttcccc gcgcgggcat   2280

ctgtccaggg ccttgtcgcg ctctcagtct ccttcgcagc ctggccccaa ccgttcaact   2340

tcaataaagc aaaactccag ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2400


<210>  2136
<211>  216
<212>  PRT
<213>  Homosapiens

<400>  2136

Met Val Pro Met His Leu Leu Gly Arg Leu Glu Lys Pro Leu Leu Leu 
1               5                   10                  15      


Leu Cys Cys Ala Ser Phe Leu Leu Gly Leu Ala Leu Leu Gly Ile Lys 
            20                  25                  30          


Thr Asp Ile Thr Pro Val Ala Tyr Phe Phe Leu Thr Leu Gly Gly Phe 
        35                  40                  45              


Phe Leu Phe Ala Tyr Leu Leu Val Arg Phe Leu Glu Trp Gly Leu Arg 
    50                  55                  60                  


Ser Gln Leu Gln Ser Met Gln Thr Glu Ser Pro Gly Pro Ser Gly Asn 
65                  70                  75                  80  


Ala Arg Asp Asn Glu Ala Phe Glu Val Pro Val Tyr Glu Glu Ala Val 
                85                  90                  95      


Val Gly Leu Glu Ser Gln Cys Arg Pro Gln Glu Leu Asp Gln Pro Pro 
            100                 105                 110         


Pro Tyr Ser Thr Val Val Ile Pro Pro Ala Pro Glu Glu Glu Gln Pro 
        115                 120                 125             


Ser His Pro Glu Gly Ser Arg Arg Ala Lys Leu Glu Gln Arg Arg Met 
    130                 135                 140                 


Ala Ser Glu Gly Ser Met Ala Gln Glu Gly Ser Pro Gly Arg Ala Pro 
145                 150                 155                 160 


Ile Asn Leu Arg Leu Arg Gly Pro Arg Ala Val Ser Thr Ala Pro Asp 
                165                 170                 175     


Leu Gln Ser Leu Ala Ala Val Pro Thr Leu Glu Pro Leu Thr Pro Pro 
            180                 185                 190         


Pro Ala Tyr Asp Val Cys Phe Gly His Pro Asp Asp Asp Ser Val Phe 
        195                 200                 205             


Tyr Glu Asp Asn Trp Ala Pro Pro 
    210                 215     


<210>  2137
<211>  4145
<212>  DNA
<213>  Homosapiens

<400>  2137
gggtggcctg gtgtgtgggc gcggcagggc gcaggcgcag gcgcagtgtg cgtccgcgtc     60

tgaggggagg gatgtggggg aagcgacggc ccccggtttg tttgggctgt gggcggtgcg    120

cagcggagag cccgggaaaa gcgggaaatg gcggcgccga gcgcggggtc ttggtccacc    180

ttccagcaca aggagctgat ggccgctgac aggggacgca ggatattggg agtgtgtggc    240

atgcatcctc atcatcagga aactctaaaa aagaaccgag tggtgctagc caaacagctg    300

ttgttgagcg aattgttaga acatcttctg gagaaggaca tcatcacctt ggaaatgagg    360

gagctcatcc aggccaaagt gggcagtttc agccagaatg tggaactcct caacttgctg    420

cctaagaggg gtccccaagc ttttgatgcc ttctgtgaag cactgaggga gaccaagcaa    480

ggccacctgg aggatatgtt gctcaccacc ctttctgggc ttcagcatgt actcccaccg    540

ttgagctgtg actacgactt gagtctccct tttccggtgt gtgagtcctg tcccctttac    600

aagaagctcc gcctgtcgac agatactgtg gaacactccc tagacaataa agatggtcct    660

gtctgccttc aggtgaagcc ttgcactcct gaattttatc aaacacactt ccagctggca    720

tataggttgc agtctcggcc tcgtggccta gcactggtgt tgagcaatgt gcacttcact    780

ggagagaaag aactggaatt tcgctctgga ggggatgtgg accacagtac tctagtcacc    840

ctcttcaagc ttttgggcta tgacgtccat gttctatgtg accagactgc acaggaaatg    900

caagagaaac tgcagaattt tgcacagtta cctgcacacc gagtcacgga ctcctgcatc    960

gtggcactcc tctcgcatgg tgtggagggc gccatctatg gtgtggatgg gaaactgctc   1020

cagctccaag aggtttttca gctctttgac aacgccaact gcccaagcct acagaacaaa   1080

ccaaaaatgt tcttcatcca ggcctgccgt ggagatgaga ctgatcgtgg ggttgaccaa   1140

caagatggaa agaaccacgc aggatcccct gggtgcgagg agagtgatgc cggtaaagaa   1200

aagttgccga agatgagact gcccacgcgc tcagacatga tatgcggcta tgcctgcctc   1260

aaagggactg ccgccatgcg gaacaccaaa cgaggttcct ggtacatcga ggctcttgct   1320

caagtgtttt ctgagcgggc ttgtgatatg cacgtggccg acatgctggt taaggtgaac   1380

gcacttatca aggatcggga aggttatgct cctggcacag aattccaccg gtgcaaggag   1440

atgtctgaat actgcagcac tctgtgccgc cacctctacc tgttcccagg acaccctccc   1500

acatgatgtc acctccccat catccacgcc aagtggaagc cactggacca caggaggtgt   1560

gatagagcct ttgatcttca ggatgcacgg tttctgttct gccccctcag ggatgtggga   1620

atctcccaga cttgtttcct gtgcccatca tctctgcctt tgagtgtggg actccaggcc   1680

agctcctttt ctgtgaagcc ctttgcctgt agagccagcc ttggttggac ctattgccag   1740

gaatgtttca gctgcagttg aagagcctga caagtgaagt tgtaaacaca gtgtggttat   1800

ggggagaggg catataaatt ccccatattt gtgttcagtt ccagcttttg tagatggcac   1860

tttagtgatt gcttttatta cattagttaa gatgtctgag agaccatctc ctatctttta   1920

tttcattcat atcctccgcc ctttttgtcc tagagtgaga gtttggaagg tgtccaaatt   1980

taatgtagac attatctttt ggctctgaag aagcaaacat gactagagac gcaccttgct   2040

gcagtgtcca gaagcggcct gtgcgttccc ttcagtactg cagcgccacc cagtggaagg   2100

acactcttgg ctcgtttggg ctcaaggcac cgcagcctgt cagccaacat tgccttgcat   2160

ttgtacctta ttgatctttg cccatggaag tctcaaagat ctttcgttgg ttgtttctct   2220

gagctttgtt actgaaatga gcctcgtggg gagcatcaga gaaggccagg aagaatggtg   2280

tgtttcccta gactctgtaa ccacctctct gtctttttcc ttcctgagaa acgtccatct   2340

ctctccctta ctattcccac tttcattcaa tcaacctgca cttcatatct agatttctag   2400

aaaagcttcc tagcttatct ccctgcttca tatctctccc ttctttacct tcatttcatc   2460

ctgttggctg ctgccaccaa atctgtctag aatcctgctt tacaggatca tgtaaatgct   2520

caaagatgta atgtagttct ttgttcctgc tttctctttc agtattaaac tctcctttga   2580

tattatgtgg cttttatttc agtgccatac atgttattgt tttcaaccta gaaaccttta   2640

tccctgctta tctgaaactt cccaacttcc ctgttcttta agactttttt tttttttttt   2700

tttttttttg agacagagtc tcgctctgtc gcccaggctg gagggcagtg gcacgatctc   2760

agctcactgc aagctccaac tcccgggttc acgccattct cctgcctcag ccttccaagt   2820

agctgggact acaggtgccc gccaccgtgc ccggctaatt tttttgtatt tttagtagag   2880

acagggtttc accatgttag ccgggatggt cttgatctcc tgacctcatg atccacccac   2940

ctcagcctcc caaagtgttg ggattacagg cgtgagccac tgcgcccggg caagaccttt   3000

ttttaaaaaa aaaaaaaaaa aaacttccat tctttcttcc tccagtctgt tctcacataa   3060

cagagtagtt ttggttttta attttttttg gttgtttgct gttttttgtt ttttaaggtg   3120

agttctcact atgtttctca gactggtctc gaactcctgg cctcaagcca tcttcccgcc   3180

tcagcctctc aaatagctgg gcttacaggc atgagccacc acacctggcc aggatttggt   3240

tgtttaaata taaatctgat cacccccctg cttagaaccc ttctgctttc tattacccct   3300

catttaaaat gtaaactctt caccttggtt tatgagaact ggttcttgcc ttccccttga   3360

acctcattaa atggtgattt cttgctaagc tccagcccga gtggtctcct ctcagcttct   3420

aattttgtgc tctttcctgc ccttttcctg ggccttctca gctctccacc cccaccactc   3480

ttgactcagg tggtgtcctt cttcctcaag tcttgacaat tcccgggccc ttcagtccct   3540

gagcagtcta cttctgtgtc tgtcaccaca tcttgtcttt tcccctcatt gcatttattg   3600

cagtttatat atatgctact tttacttgtt catttctgtc tcccctacca ggctgtaaat   3660

gagggcagaa accttgtttg ttttattcac catcatgtac caagtgcttg gcacatagtg   3720

ggccttcatt aaatgtttgt tgaataaaag agggaagaag gcaagccaac cttagctaca   3780

atcctacctt ttgataaaat gttccttttg acaatataca cggattatta tttgtacttt   3840

gtttttccat gtgttttgct tttatccact ggcattttta gctccttgaa gacatatcat   3900

gtgtgagata acttccttca catctcccat ggtccctagc aaaatgctag gcctgtagta   3960

gtcaaggtgc tcaataaata tttgtttggg tggtttgtga gccttgctgc caagtcctgc   4020

ctttgggtcg acatagtatg gaagtatttg agagagagaa cctttccact cccactgcca   4080

ggattttgta ttgccatcgg gtgccaaata aatgctcata tttattaaaa aaaaaaaaaa   4140

aaaaa                                                               4145


<210>  2138
<211>  452
<212>  PRT
<213>  Homosapiens

<400>  2138

Met Ala Ala Pro Ser Ala Gly Ser Trp Ser Thr Phe Gln His Lys Glu 
1               5                   10                  15      


Leu Met Ala Ala Asp Arg Gly Arg Arg Ile Leu Gly Val Cys Gly Met 
            20                  25                  30          


His Pro His His Gln Glu Thr Leu Lys Lys Asn Arg Val Val Leu Ala 
        35                  40                  45              


Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys Asp 
    50                  55                  60                  


Ile Ile Thr Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly Ser 
65                  70                  75                  80  


Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro 
                85                  90                  95      


Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg Glu Thr Lys Gln Gly 
            100                 105                 110         


His Leu Glu Asp Met Leu Leu Thr Thr Leu Ser Gly Leu Gln His Val 
        115                 120                 125             


Leu Pro Pro Leu Ser Cys Asp Tyr Asp Leu Ser Leu Pro Phe Pro Val 
    130                 135                 140                 


Cys Glu Ser Cys Pro Leu Tyr Lys Lys Leu Arg Leu Ser Thr Asp Thr 
145                 150                 155                 160 


Val Glu His Ser Leu Asp Asn Lys Asp Gly Pro Val Cys Leu Gln Val 
                165                 170                 175     


Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr 
            180                 185                 190         


Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val 
        195                 200                 205             


His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val 
    210                 215                 220                 


Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val 
225                 230                 235                 240 


His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln 
                245                 250                 255     


Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val 
            260                 265                 270         


Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
        275                 280                 285             


Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn 
    290                 295                 300                 


Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
305                 310                 315                 320 


Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp Gly Lys Asn 
                325                 330                 335     


His Ala Gly Ser Pro Gly Cys Glu Glu Ser Asp Ala Gly Lys Glu Lys 
            340                 345                 350         


Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
        355                 360                 365             


Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
    370                 375                 380                 


Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp 
385                 390                 395                 400 


Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp 
                405                 410                 415     


Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met 
            420                 425                 430         


Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly 
        435                 440                 445             


His Pro Pro Thr 
    450         


<210>  2139
<211>  3927
<212>  DNA
<213>  Homosapiens

<400>  2139
gggtggcctg gtgtgtgggc gcggcagggc gcaggcgcag gcgcagtgtg cgtccgcgtc     60

tgaggggagg gatgtggggg aagcgacggc ccccggtttg tttgggctgt gggcggtgcg    120

cagcggagag cccgggaaaa gcgggaaatg gcggcgccga gcgcggggtc ttggtccacc    180

ttccagcaca aggagctgat ggccgctgac aggggacgca ggatattggg agtgtgtggc    240

atgcatcctc atcatcagga aactctaaaa aagaaccgag tggtgctagc caaacagctg    300

ttgttgagcg aattgttaga acatcttctg gagaaggaca tcatcacctt ggaaatgagg    360

gagctcatcc aggccaaagt gggcagtttc agccagaatg tggaactcct caacttgctg    420

cctaagaggg gtccccaagc ttttgatgcc ttctgtgaag ccttgcactc ctgaatttta    480

tcaaacacac ttccagctgg catataggtt gcagtctcgg cctcgtggcc tagcactggt    540

gttgagcaat gtgcacttca ctggagagaa agaactggaa tttcgctctg gaggggatgt    600

ggaccacagt actctagtca ccctcttcaa gcttttgggc tatgacgtcc atgttctatg    660

tgaccagact gcacaggaaa tgcaagagaa actgcagaat tttgcacagt tacctgcaca    720

ccgagtcacg gactcctgca tcgtggcact cctctcgcat ggtgtggagg gcgccatcta    780

tggtgtggat gggaaactgc tccagctcca agaggttttt cagctctttg acaacgccaa    840

ctgcccaagc ctacagaaca aaccaaaaat gttcttcatc caggcctgcc gtggagatga    900

gactgatcgt ggggttgacc aacaagatgg aaagaaccac gcaggatccc ctgggtgcga    960

ggagagtgat gccggtaaag aaaagttgcc gaagatgaga ctgcccacgc gctcagacat   1020

gatatgcggc tatgcctgcc tcaaagggac tgccgccatg cggaacacca aacgaggttc   1080

ctggtacatc gaggctcttg ctcaagtgtt ttctgagcgg gcttgtgata tgcacgtggc   1140

cgacatgctg gttaaggtga acgcacttat caaggatcgg gaaggttatg ctcctggcac   1200

agaattccac cggtgcaagg agatgtctga atactgcagc actctgtgcc gccacctcta   1260

cctgttccca ggacaccctc ccacatgatg tcacctcccc atcatccacg ccaagtggaa   1320

gccactggac cacaggaggt gtgatagagc ctttgatctt caggatgcac ggtttctgtt   1380

ctgccccctc agggatgtgg gaatctccca gacttgtttc ctgtgcccat catctctgcc   1440

tttgagtgtg ggactccagg ccagctcctt ttctgtgaag ccctttgcct gtagagccag   1500

ccttggttgg acctattgcc aggaatgttt cagctgcagt tgaagagcct gacaagtgaa   1560

gttgtaaaca cagtgtggtt atggggagag ggcatataaa ttccccatat ttgtgttcag   1620

ttccagcttt tgtagatggc actttagtga ttgcttttat tacattagtt aagatgtctg   1680

agagaccatc tcctatcttt tatttcattc atatcctccg ccctttttgt cctagagtga   1740

gagtttggaa ggtgtccaaa tttaatgtag acattatctt ttggctctga agaagcaaac   1800

atgactagag acgcaccttg ctgcagtgtc cagaagcggc ctgtgcgttc ccttcagtac   1860

tgcagcgcca cccagtggaa ggacactctt ggctcgtttg ggctcaaggc accgcagcct   1920

gtcagccaac attgccttgc atttgtacct tattgatctt tgcccatgga agtctcaaag   1980

atctttcgtt ggttgtttct ctgagctttg ttactgaaat gagcctcgtg gggagcatca   2040

gagaaggcca ggaagaatgg tgtgtttccc tagactctgt aaccacctct ctgtcttttt   2100

ccttcctgag aaacgtccat ctctctccct tactattccc actttcattc aatcaacctg   2160

cacttcatat ctagatttct agaaaagctt cctagcttat ctccctgctt catatctctc   2220

ccttctttac cttcatttca tcctgttggc tgctgccacc aaatctgtct agaatcctgc   2280

tttacaggat catgtaaatg ctcaaagatg taatgtagtt ctttgttcct gctttctctt   2340

tcagtattaa actctccttt gatattatgt ggcttttatt tcagtgccat acatgttatt   2400

gttttcaacc tagaaacctt tatccctgct tatctgaaac ttcccaactt ccctgttctt   2460

taagactttt tttttttttt tttttttttt tgagacagag tctcgctctg tcgcccaggc   2520

tggagggcag tggcacgatc tcagctcact gcaagctcca actcccgggt tcacgccatt   2580

ctcctgcctc agccttccaa gtagctggga ctacaggtgc ccgccaccgt gcccggctaa   2640

tttttttgta tttttagtag agacagggtt tcaccatgtt agccgggatg gtcttgatct   2700

cctgacctca tgatccaccc acctcagcct cccaaagtgt tgggattaca ggcgtgagcc   2760

actgcgcccg ggcaagacct ttttttaaaa aaaaaaaaaa aaaaacttcc attctttctt   2820

cctccagtct gttctcacat aacagagtag ttttggtttt taattttttt tggttgtttg   2880

ctgttttttg ttttttaagg tgagttctca ctatgtttct cagactggtc tcgaactcct   2940

ggcctcaagc catcttcccg cctcagcctc tcaaatagct gggcttacag gcatgagcca   3000

ccacacctgg ccaggatttg gttgtttaaa tataaatctg atcacccccc tgcttagaac   3060

ccttctgctt tctattaccc ctcatttaaa atgtaaactc ttcaccttgg tttatgagaa   3120

ctggttcttg ccttcccctt gaacctcatt aaatggtgat ttcttgctaa gctccagccc   3180

gagtggtctc ctctcagctt ctaattttgt gctctttcct gcccttttcc tgggccttct   3240

cagctctcca cccccaccac tcttgactca ggtggtgtcc ttcttcctca agtcttgaca   3300

attcccgggc ccttcagtcc ctgagcagtc tacttctgtg tctgtcacca catcttgtct   3360

tttcccctca ttgcatttat tgcagtttat atatatgcta cttttacttg ttcatttctg   3420

tctcccctac caggctgtaa atgagggcag aaaccttgtt tgttttattc accatcatgt   3480

accaagtgct tggcacatag tgggccttca ttaaatgttt gttgaataaa agagggaaga   3540

aggcaagcca accttagcta caatcctacc ttttgataaa atgttccttt tgacaatata   3600

cacggattat tatttgtact ttgtttttcc atgtgttttg cttttatcca ctggcatttt   3660

tagctccttg aagacatatc atgtgtgaga taacttcctt cacatctccc atggtcccta   3720

gcaaaatgct aggcctgtag tagtcaaggt gctcaataaa tatttgtttg ggtggtttgt   3780

gagccttgct gccaagtcct gcctttgggt cgacatagta tggaagtatt tgagagagag   3840

aacctttcca ctcccactgc caggattttg tattgccatc gggtgccaaa taaatgctca   3900

tatttattaa aaaaaaaaaa aaaaaaa                                       3927


<210>  2140
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  2140

Met Ala Ala Pro Ser Ala Gly Ser Trp Ser Thr Phe Gln His Lys Glu 
1               5                   10                  15      


Leu Met Ala Ala Asp Arg Gly Arg Arg Ile Leu Gly Val Cys Gly Met 
            20                  25                  30          


His Pro His His Gln Glu Thr Leu Lys Lys Asn Arg Val Val Leu Ala 
        35                  40                  45              


Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys Asp 
    50                  55                  60                  


Ile Ile Thr Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly Ser 
65                  70                  75                  80  


Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro 
                85                  90                  95      


Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu His Ser 
            100                 105             


<210>  2141
<211>  3093
<212>  DNA
<213>  Homosapiens

<400>  2141
agcaagagca gaggcttaag gagctacact gggggaagga caggggcaag caggccaagg     60

cctggccggg gctcgggggg agggaatatg gagcaatccc ggtcacagca gcgtgggggt    120

gaacaaagct ggtggggtag tgacccccag taccagtata tgccctttga acactgcacc    180

agctacggac tgccctctga gaatgggggc ctccagcaca ggctccggaa ggatgcaggc    240

ccccgccaca acgtccaccc cacacagatt tatggccatc acaaagaaca attctcagac    300

agggagcagg acatagggat gcccaagaag acaggctcca gttctaccgt ggacagcaag    360

gatgaggatc actattctaa atgtcaagat tgtatccacc gcctgggaca ggtggtgaga    420

agaaaattag gggaagactg gatctttctg gtgcttctgg gactgctgat ggctctggtc    480

agctggagca tggactacgt cagtgccaaa agccttcagg cctacaagtg gtcctacgcg    540

cagatgcagc ccagccttcc tctgcagttc ctggtctggg tcaccttccc actagtcctc    600

atcctcttca gcgccctctt ctgccacctc atctctcccc aggctgttgg ctctggaatc    660

cccgaaatga agacaatact tcgtggggtt gtcctgaagg aatacctcac aatgaaagcc    720

tttgtggcca aggttgtcgc cctgactgcg ggcctgggca gtggcatccc cgtggggaaa    780

gagggcccct tcgtccacat tgccagcatc tgtgctgctg tcctcagcaa attcatgtct    840

gtgttctgcg gggtatatga gcagccatac tactactctg atatcctgac ggtgggctgt    900

gctgtgggag tcggctgttg ttttgggaca ccacttggag gagtgctatt tagcatcgag    960

gtcacctcca cctactttgc tgttcggaac tactggagag gattctttgc agccacgttc   1020

agcgcctttg tgtttcgagt gctggcagtg tggaacaagg atgctgtcac catcactgct   1080

ctgttcagaa ccaatttccg aatggatttc ccctttgacc tgaaggaact accagctttt   1140

gctgccatcg ggatttgctg tgggctcctg ggagctgtat ttgtgtatct gcatcgccaa   1200

gtcatgctcg gtgtccgaaa gcacaaggcc ctcagccagt ttcttgctaa gcaccgcctg   1260

ctgtatcctg gaattgttac ctttgtcatt gcctcattca ccttcccacc aggaatgggt   1320

caattcatgg ctggagagtt gatgccccgc gaagccatca gtactttgtt tgacaacaat   1380

acatgggtga aacacgcggg tgatcctgag agcctgggcc agtcagctgt gtggattcac   1440

ccccgggtca acgttgtcat catcatcttt ctcttcttcg tcatgaagtt ctggatgtcc   1500

atcgtggcca ccactatgcc cataccctgc ggaggcttca tgcctgtgtt tgtgctagga   1560

gctgcatttg gaaggctggt aggagaaatc atggccatgc tctttcctga tggtattttg   1620

tttgatgaca tcatctacaa gatcctacct gggggctatg cagtaattgg agcagcagcg   1680

ctgactggtg ccgtttccca cacagtctcc acagctgtga tttgcttcga attaacgggt   1740

cagattgctc acatcctgcc catgatggtg gctgttatct tggccaacat ggtggcccag   1800

agcctgcagc cctctctcta tgacagcatc atccaggtca agaagctacc ctacttgcct   1860

gaccttggct ggaaccagct cagcaaatat accatctttg ttgaggacat catggtacgt   1920

gatgtgaagt ttgtttcagc ttcttacaca tatggggagt tgcgaaccct gctccagacc   1980

accacagtca agactttacc actggttgac tcaaaagatt caatgatcct gctgggctcg   2040

gtggagcggt cggaactgca ggccctcctg cagcgccacc tgtgtcctga gcgcaggctg   2100

cgcgcagccc aagagatggc gcggaagttg tcggagctgc cttacgacgg gaaggcgcgg   2160

ctggctgggg aggggccccc cggcgcgcct ccaggccggc ccgagtcctt cgcctttgtg   2220

gatgaggatg aggacgaaga tctctctggc aagagcgagc ttcctccttc ccttgctctc   2280

cacccctcta ctactgcccc tctgtcccca gaagagccca atgggcctct gcctggccac   2340

aaacagcagc cggaagcacc agagcctgca ggtcaaagac cctccatctt ccagtccctg   2400

cttcactgct tgctgggcag agctcgcccc acaaagaaga aaacaaccca ggattccaca   2460

gatttagtgg ataacatgtc acctgaagag attgaggcct gggagcagga gcagctgagc   2520

cagcctgtct gttttgattc ctgctgtatt gaccagtctc ccttccagct ggtggagcag   2580

acaaccctgc acaagactca taccctgttt tcactccttg gcctccacct cgcttacgtg   2640

accagcatgg ggaagctcag gggcgtcctg gccctggagg agctacagaa ggccattgag   2700

gggcacacca agtctggggt gcagctccgc cctccccttg ccagcttccg gaacacgact   2760

tcaactcgaa agagtaccgg ggcacctcca tcttctgcag agaactggaa cctgcctgag   2820

gacaggcctg gggccactgg aacaggggat gtgattgctg cctccccaga gacccctgtg   2880

ccatctcctt ccccagagcc ccctctctcc ctggccccag gcaaggtaga gggcgagttg   2940

gaggagctgg agctggtgga gagtccaggg ctggaagagg agctggccga catcttgcag   3000

ggccccagcc tgcgatccac agacgaggag gatgaggatg aactgatcct ttgaccccct   3060

cccacgacct cctcataaag accgtggaga ggc                                3093


<210>  2142
<211>  988
<212>  PRT
<213>  Homosapiens

<400>  2142

Met Glu Gln Ser Arg Ser Gln Gln Arg Gly Gly Glu Gln Ser Trp Trp 
1               5                   10                  15      


Gly Ser Asp Pro Gln Tyr Gln Tyr Met Pro Phe Glu His Cys Thr Ser 
            20                  25                  30          


Tyr Gly Leu Pro Ser Glu Asn Gly Gly Leu Gln His Arg Leu Arg Lys 
        35                  40                  45              


Asp Ala Gly Pro Arg His Asn Val His Pro Thr Gln Ile Tyr Gly His 
    50                  55                  60                  


His Lys Glu Gln Phe Ser Asp Arg Glu Gln Asp Ile Gly Met Pro Lys 
65                  70                  75                  80  


Lys Thr Gly Ser Ser Ser Thr Val Asp Ser Lys Asp Glu Asp His Tyr 
                85                  90                  95      


Ser Lys Cys Gln Asp Cys Ile His Arg Leu Gly Gln Val Val Arg Arg 
            100                 105                 110         


Lys Leu Gly Glu Asp Trp Ile Phe Leu Val Leu Leu Gly Leu Leu Met 
        115                 120                 125             


Ala Leu Val Ser Trp Ser Met Asp Tyr Val Ser Ala Lys Ser Leu Gln 
    130                 135                 140                 


Ala Tyr Lys Trp Ser Tyr Ala Gln Met Gln Pro Ser Leu Pro Leu Gln 
145                 150                 155                 160 


Phe Leu Val Trp Val Thr Phe Pro Leu Val Leu Ile Leu Phe Ser Ala 
                165                 170                 175     


Leu Phe Cys His Leu Ile Ser Pro Gln Ala Val Gly Ser Gly Ile Pro 
            180                 185                 190         


Glu Met Lys Thr Ile Leu Arg Gly Val Val Leu Lys Glu Tyr Leu Thr 
        195                 200                 205             


Met Lys Ala Phe Val Ala Lys Val Val Ala Leu Thr Ala Gly Leu Gly 
    210                 215                 220                 


Ser Gly Ile Pro Val Gly Lys Glu Gly Pro Phe Val His Ile Ala Ser 
225                 230                 235                 240 


Ile Cys Ala Ala Val Leu Ser Lys Phe Met Ser Val Phe Cys Gly Val 
                245                 250                 255     


Tyr Glu Gln Pro Tyr Tyr Tyr Ser Asp Ile Leu Thr Val Gly Cys Ala 
            260                 265                 270         


Val Gly Val Gly Cys Cys Phe Gly Thr Pro Leu Gly Gly Val Leu Phe 
        275                 280                 285             


Ser Ile Glu Val Thr Ser Thr Tyr Phe Ala Val Arg Asn Tyr Trp Arg 
    290                 295                 300                 


Gly Phe Phe Ala Ala Thr Phe Ser Ala Phe Val Phe Arg Val Leu Ala 
305                 310                 315                 320 


Val Trp Asn Lys Asp Ala Val Thr Ile Thr Ala Leu Phe Arg Thr Asn 
                325                 330                 335     


Phe Arg Met Asp Phe Pro Phe Asp Leu Lys Glu Leu Pro Ala Phe Ala 
            340                 345                 350         


Ala Ile Gly Ile Cys Cys Gly Leu Leu Gly Ala Val Phe Val Tyr Leu 
        355                 360                 365             


His Arg Gln Val Met Leu Gly Val Arg Lys His Lys Ala Leu Ser Gln 
    370                 375                 380                 


Phe Leu Ala Lys His Arg Leu Leu Tyr Pro Gly Ile Val Thr Phe Val 
385                 390                 395                 400 


Ile Ala Ser Phe Thr Phe Pro Pro Gly Met Gly Gln Phe Met Ala Gly 
                405                 410                 415     


Glu Leu Met Pro Arg Glu Ala Ile Ser Thr Leu Phe Asp Asn Asn Thr 
            420                 425                 430         


Trp Val Lys His Ala Gly Asp Pro Glu Ser Leu Gly Gln Ser Ala Val 
        435                 440                 445             


Trp Ile His Pro Arg Val Asn Val Val Ile Ile Ile Phe Leu Phe Phe 
    450                 455                 460                 


Val Met Lys Phe Trp Met Ser Ile Val Ala Thr Thr Met Pro Ile Pro 
465                 470                 475                 480 


Cys Gly Gly Phe Met Pro Val Phe Val Leu Gly Ala Ala Phe Gly Arg 
                485                 490                 495     


Leu Val Gly Glu Ile Met Ala Met Leu Phe Pro Asp Gly Ile Leu Phe 
            500                 505                 510         


Asp Asp Ile Ile Tyr Lys Ile Leu Pro Gly Gly Tyr Ala Val Ile Gly 
        515                 520                 525             


Ala Ala Ala Leu Thr Gly Ala Val Ser His Thr Val Ser Thr Ala Val 
    530                 535                 540                 


Ile Cys Phe Glu Leu Thr Gly Gln Ile Ala His Ile Leu Pro Met Met 
545                 550                 555                 560 


Val Ala Val Ile Leu Ala Asn Met Val Ala Gln Ser Leu Gln Pro Ser 
                565                 570                 575     


Leu Tyr Asp Ser Ile Ile Gln Val Lys Lys Leu Pro Tyr Leu Pro Asp 
            580                 585                 590         


Leu Gly Trp Asn Gln Leu Ser Lys Tyr Thr Ile Phe Val Glu Asp Ile 
        595                 600                 605             


Met Val Arg Asp Val Lys Phe Val Ser Ala Ser Tyr Thr Tyr Gly Glu 
    610                 615                 620                 


Leu Arg Thr Leu Leu Gln Thr Thr Thr Val Lys Thr Leu Pro Leu Val 
625                 630                 635                 640 


Asp Ser Lys Asp Ser Met Ile Leu Leu Gly Ser Val Glu Arg Ser Glu 
                645                 650                 655     


Leu Gln Ala Leu Leu Gln Arg His Leu Cys Pro Glu Arg Arg Leu Arg 
            660                 665                 670         


Ala Ala Gln Glu Met Ala Arg Lys Leu Ser Glu Leu Pro Tyr Asp Gly 
        675                 680                 685             


Lys Ala Arg Leu Ala Gly Glu Gly Pro Pro Gly Ala Pro Pro Gly Arg 
    690                 695                 700                 


Pro Glu Ser Phe Ala Phe Val Asp Glu Asp Glu Asp Glu Asp Leu Ser 
705                 710                 715                 720 


Gly Lys Ser Glu Leu Pro Pro Ser Leu Ala Leu His Pro Ser Thr Thr 
                725                 730                 735     


Ala Pro Leu Ser Pro Glu Glu Pro Asn Gly Pro Leu Pro Gly His Lys 
            740                 745                 750         


Gln Gln Pro Glu Ala Pro Glu Pro Ala Gly Gln Arg Pro Ser Ile Phe 
        755                 760                 765             


Gln Ser Leu Leu His Cys Leu Leu Gly Arg Ala Arg Pro Thr Lys Lys 
    770                 775                 780                 


Lys Thr Thr Gln Asp Ser Thr Asp Leu Val Asp Asn Met Ser Pro Glu 
785                 790                 795                 800 


Glu Ile Glu Ala Trp Glu Gln Glu Gln Leu Ser Gln Pro Val Cys Phe 
                805                 810                 815     


Asp Ser Cys Cys Ile Asp Gln Ser Pro Phe Gln Leu Val Glu Gln Thr 
            820                 825                 830         


Thr Leu His Lys Thr His Thr Leu Phe Ser Leu Leu Gly Leu His Leu 
        835                 840                 845             


Ala Tyr Val Thr Ser Met Gly Lys Leu Arg Gly Val Leu Ala Leu Glu 
    850                 855                 860                 


Glu Leu Gln Lys Ala Ile Glu Gly His Thr Lys Ser Gly Val Gln Leu 
865                 870                 875                 880 


Arg Pro Pro Leu Ala Ser Phe Arg Asn Thr Thr Ser Thr Arg Lys Ser 
                885                 890                 895     


Thr Gly Ala Pro Pro Ser Ser Ala Glu Asn Trp Asn Leu Pro Glu Asp 
            900                 905                 910         


Arg Pro Gly Ala Thr Gly Thr Gly Asp Val Ile Ala Ala Ser Pro Glu 
        915                 920                 925             


Thr Pro Val Pro Ser Pro Ser Pro Glu Pro Pro Leu Ser Leu Ala Pro 
    930                 935                 940                 


Gly Lys Val Glu Gly Glu Leu Glu Glu Leu Glu Leu Val Glu Ser Pro 
945                 950                 955                 960 


Gly Leu Glu Glu Glu Leu Ala Asp Ile Leu Gln Gly Pro Ser Leu Arg 
                965                 970                 975     


Ser Thr Asp Glu Glu Asp Glu Asp Glu Leu Ile Leu 
            980                 985             


<210>  2143
<211>  2322
<212>  DNA
<213>  Homosapiens

<400>  2143
cccgccccct ctcttctccc tccctcctcc ttccgtgtgt ccctccccgc ccggctggag     60

gctgctccgg accgggacgc agagtctgcg gacccggcgc cgaggcggcc acccgagacg    120

cggcgcgcac gctccggcct gcgcccggcc cggccatggc ggccccccgc ccgtctcccg    180

cgatctccgt ttcggtctcg gctccggctt tttacgcccc gcagaagaag ttcggccctg    240

tggtggcccc aaagcccaaa gtgaatccct tccggcccgg ggacagcgag cctcccccgg    300

cacccggggc ccagcgcgca cagatgggcc gggtgggcga gattcccccg ccgcccccgg    360

aagactttcc cctgcctcca cctccccttg ctggggatgg cgacgatgca gagggtgctc    420

tgggaggtgc cttcccgccg ccccctcccc cgatcgagga atcatttccc cctgcgcctc    480

tggaggagga gatcttccct tccccgccgc ctcctccgga ggaggaggga gggcctgagg    540

cccccatacc gcccccacca cagcccaggg agaaggtgag cagtattgat ttggagatcg    600

actctctgtc ctcactgctg gatgacatga ccaagaatga tcctttcaaa gcccgggtgt    660

catctggata tgtgccccca ccagtggcca ctccattcag ttccaagtcc agtaccaagc    720

ctgcagccgg gggcacagca cccctgcctc cttggaagtc cccttccagc tcccagcctc    780

tgccccaggt tccggctccg gctcagagcc agacacagtt ccatgttcag ccccagcccc    840

agcccaagcc tcaggtccaa ctccatgtcc agtcccagac ccagcctgtg tctttggcta    900

acacccagcc ccgagggccc ccagcctcat ctccggctcc agcccctaag ttttctccag    960

tgactcctaa gtttactcct gtggcttcca agttcagtcc tggagcccca ggtggatctg   1020

ggtcacaacc aaatcaaaaa ttggggcacc ccgaagctct ttctgctggc acaggctccc   1080

ctcaacctcc cagcttcacc tatgcccagc agagggagaa gccccgagtg caggagaagc   1140

agcaccccgt gcccccaccg gctcagaacc aaaaccaggt gcgctcccct ggggccccag   1200

ggcccctgac tctgaaggag gtggaggagc tggagcagct gacccagcag ctaatgcagg   1260

acatggagca tcctcagagg cagaatgtgg ctgtcaacga actctgcggc cgatgccatc   1320

aacccctggc ccgggcgcag ccagccgtcc gcgctctagg gcagctgttc cacatcgcct   1380

gcttcacctg ccaccagtgt gcgcagcagc tccagggcca gcagttctac agtctggagg   1440

gggcgccgta ctgcgagggc tgttacactg acaccctgga gaagtgtaac acctgcgggg   1500

agcccatcac tgaccgcatg ctgagggcca cgggcaaggc ctatcacccg cactgcttca   1560

cctgtgtggt ctgcgcccgc cccctggagg gcacctcctt catcgtggac caggccaacc   1620

ggccccactg tgtccccgac taccacaagc agtacgcccc gaggtgctcc gtctgctctg   1680

agcccatcat gcctgagcct ggccgagatg agactgtgcg agtggtcgcc ctggacaaga   1740

acttccacat gaagtgttac aagtgtgagg actgcgggaa gcccctgtcg attgaggcag   1800

atgacaatgg ctgcttcccc ctggacggtc acgtgctctg tcggaagtgc cacactgcta   1860

gagcccagac ctgagtgagg acaggccctc ttcagaccgc agtccatgcc ccattgtgga   1920

ccacccacac tgagaccacc tgcccccacc tcagttattg ttttgatgtc tagcccctcc   1980

catttccaac ccctccctag catcccaggt gccctgaccc aggacccaac atggtctagg   2040

gatgcaggat ccccgccctg gggtctggtc ctcgcccatc ctgcagggat tgcccaccgt   2100

cttccagaca ccccacctga ggggggcacc aggtttagtg ctgctgcttt cactgctgca   2160

cccgcgccct cggccggccc cccgagcagc ctttgtactc tgcttgcgga gggctgggag   2220

accctccagg acattcccac cctcccccat gctgccaagt tgtagctata gctacaaata   2280

aaaaaaaacc ttgttttcca gaaaaaaaaa aaaaaaaaaa aa                      2322


<210>  2144
<211>  572
<212>  PRT
<213>  Homosapiens

<400>  2144

Met Ala Ala Pro Arg Pro Ser Pro Ala Ile Ser Val Ser Val Ser Ala 
1               5                   10                  15      


Pro Ala Phe Tyr Ala Pro Gln Lys Lys Phe Gly Pro Val Val Ala Pro 
            20                  25                  30          


Lys Pro Lys Val Asn Pro Phe Arg Pro Gly Asp Ser Glu Pro Pro Pro 
        35                  40                  45              


Ala Pro Gly Ala Gln Arg Ala Gln Met Gly Arg Val Gly Glu Ile Pro 
    50                  55                  60                  


Pro Pro Pro Pro Glu Asp Phe Pro Leu Pro Pro Pro Pro Leu Ala Gly 
65                  70                  75                  80  


Asp Gly Asp Asp Ala Glu Gly Ala Leu Gly Gly Ala Phe Pro Pro Pro 
                85                  90                  95      


Pro Pro Pro Ile Glu Glu Ser Phe Pro Pro Ala Pro Leu Glu Glu Glu 
            100                 105                 110         


Ile Phe Pro Ser Pro Pro Pro Pro Pro Glu Glu Glu Gly Gly Pro Glu 
        115                 120                 125             


Ala Pro Ile Pro Pro Pro Pro Gln Pro Arg Glu Lys Val Ser Ser Ile 
    130                 135                 140                 


Asp Leu Glu Ile Asp Ser Leu Ser Ser Leu Leu Asp Asp Met Thr Lys 
145                 150                 155                 160 


Asn Asp Pro Phe Lys Ala Arg Val Ser Ser Gly Tyr Val Pro Pro Pro 
                165                 170                 175     


Val Ala Thr Pro Phe Ser Ser Lys Ser Ser Thr Lys Pro Ala Ala Gly 
            180                 185                 190         


Gly Thr Ala Pro Leu Pro Pro Trp Lys Ser Pro Ser Ser Ser Gln Pro 
        195                 200                 205             


Leu Pro Gln Val Pro Ala Pro Ala Gln Ser Gln Thr Gln Phe His Val 
    210                 215                 220                 


Gln Pro Gln Pro Gln Pro Lys Pro Gln Val Gln Leu His Val Gln Ser 
225                 230                 235                 240 


Gln Thr Gln Pro Val Ser Leu Ala Asn Thr Gln Pro Arg Gly Pro Pro 
                245                 250                 255     


Ala Ser Ser Pro Ala Pro Ala Pro Lys Phe Ser Pro Val Thr Pro Lys 
            260                 265                 270         


Phe Thr Pro Val Ala Ser Lys Phe Ser Pro Gly Ala Pro Gly Gly Ser 
        275                 280                 285             


Gly Ser Gln Pro Asn Gln Lys Leu Gly His Pro Glu Ala Leu Ser Ala 
    290                 295                 300                 


Gly Thr Gly Ser Pro Gln Pro Pro Ser Phe Thr Tyr Ala Gln Gln Arg 
305                 310                 315                 320 


Glu Lys Pro Arg Val Gln Glu Lys Gln His Pro Val Pro Pro Pro Ala 
                325                 330                 335     


Gln Asn Gln Asn Gln Val Arg Ser Pro Gly Ala Pro Gly Pro Leu Thr 
            340                 345                 350         


Leu Lys Glu Val Glu Glu Leu Glu Gln Leu Thr Gln Gln Leu Met Gln 
        355                 360                 365             


Asp Met Glu His Pro Gln Arg Gln Asn Val Ala Val Asn Glu Leu Cys 
    370                 375                 380                 


Gly Arg Cys His Gln Pro Leu Ala Arg Ala Gln Pro Ala Val Arg Ala 
385                 390                 395                 400 


Leu Gly Gln Leu Phe His Ile Ala Cys Phe Thr Cys His Gln Cys Ala 
                405                 410                 415     


Gln Gln Leu Gln Gly Gln Gln Phe Tyr Ser Leu Glu Gly Ala Pro Tyr 
            420                 425                 430         


Cys Glu Gly Cys Tyr Thr Asp Thr Leu Glu Lys Cys Asn Thr Cys Gly 
        435                 440                 445             


Glu Pro Ile Thr Asp Arg Met Leu Arg Ala Thr Gly Lys Ala Tyr His 
    450                 455                 460                 


Pro His Cys Phe Thr Cys Val Val Cys Ala Arg Pro Leu Glu Gly Thr 
465                 470                 475                 480 


Ser Phe Ile Val Asp Gln Ala Asn Arg Pro His Cys Val Pro Asp Tyr 
                485                 490                 495     


His Lys Gln Tyr Ala Pro Arg Cys Ser Val Cys Ser Glu Pro Ile Met 
            500                 505                 510         


Pro Glu Pro Gly Arg Asp Glu Thr Val Arg Val Val Ala Leu Asp Lys 
        515                 520                 525             


Asn Phe His Met Lys Cys Tyr Lys Cys Glu Asp Cys Gly Lys Pro Leu 
    530                 535                 540                 


Ser Ile Glu Ala Asp Asp Asn Gly Cys Phe Pro Leu Asp Gly His Val 
545                 550                 555                 560 


Leu Cys Arg Lys Cys His Thr Ala Arg Ala Gln Thr 
                565                 570         


<210>  2145
<211>  2325
<212>  DNA
<213>  Homosapiens

<400>  2145
cccgccccct ctcttctccc tccctcctcc ttccgtgtgt ccctccccgc ccggctggag     60

gctgctccgg accgggacgc agagtctgcg gacccggcgc cgaggcggcc acccgagacg    120

cggcgcgcac gctccggcct gcgcagcccg gcccggccat ggcggccccc cgcccgtctc    180

ccgcgatctc cgtttcggtc tcggctccgg ctttttacgc cccgcagaag aagttcggcc    240

ctgtggtggc cccaaagccc aaagtgaatc ccttccggcc cggggacagc gagcctcccc    300

cggcacccgg ggcccagcgc gcacagatgg gccgggtggg cgagattccc ccgccgcccc    360

cggaagactt tcccctgcct ccacctcccc ttgctgggga tggcgacgat gcagagggtg    420

ctctgggagg tgccttcccg ccgccccctc ccccgatcga ggaatcattt ccccctgcgc    480

ctctggagga ggagatcttc ccttccccgc cgcctcctcc ggaggaggag ggagggcctg    540

aggcccccat accgccccca ccacagccca gggagaaggt gagcagtatt gatttggaga    600

tcgactctct gtcctcactg ctggatgaca tgaccaagaa tgatcctttc aaagcccggg    660

tgtcatctgg atatgtgccc ccaccagtgg ccactccatt cagttccaag tccagtacca    720

agcctgcagc cgggggcaca gcacccctgc ctccttggaa gtccccttcc agctcccagc    780

ctctgcccca ggttccggct ccggctcaga gccagacaca gttccatgtt cagccccagc    840

cccagcccaa gcctcaggtc caactccatg tccagtccca gacccagcct gtgtctttgg    900

ctaacaccca gccccgaggg cccccagcct catctccggc tccagcccct aagttttctc    960

cagtgactcc taagtttact cctgtggctt ccaagttcag tcctggagcc ccaggtggat   1020

ctgggtcaca accaaatcaa aaattggggc accccgaagc tctttctgct ggcacaggct   1080

cccctcaacc tcccagcttc acctatgccc agcagaggga gaagccccga gtgcaggaga   1140

agcagcaccc cgtgccccca ccggctcaga accaaaacca ggtgcgctcc cctggggccc   1200

cagggcccct gactctgaag gaggtggagg agctggagca gctgacccag cagctaatgc   1260

aggacatgga gcatcctcag aggcagaatg tggctgtcaa cgaactctgc ggccgatgcc   1320

atcaacccct ggcccgggcg cagccagccg tccgcgctct agggcagctg ttccacatcg   1380

cctgcttcac ctgccaccag tgtgcgcagc agctccaggg ccagcagttc tacagtctgg   1440

agggggcgcc gtactgcgag ggctgttaca ctgacaccct ggagaagtgt aacacctgcg   1500

gggagcccat cactgaccgc atgctgaggg ccacgggcaa ggcctatcac ccgcactgct   1560

tcacctgtgt ggtctgcgcc cgccccctgg agggcacctc cttcatcgtg gaccaggcca   1620

accggcccca ctgtgtcccc gactaccaca agcagtacgc cccgaggtgc tccgtctgct   1680

ctgagcccat catgcctgag cctggccgag atgagactgt gcgagtggtc gccctggaca   1740

agaacttcca catgaagtgt tacaagtgtg aggactgcgg gaagcccctg tcgattgagg   1800

cagatgacaa tggctgcttc cccctggacg gtcacgtgct ctgtcggaag tgccacactg   1860

ctagagccca gacctgagtg aggacaggcc ctcttcagac cgcagtccat gccccattgt   1920

ggaccaccca cactgagacc acctgccccc acctcagtta ttgttttgat gtctagcccc   1980

tcccatttcc aacccctccc tagcatccca ggtgccctga cccaggaccc aacatggtct   2040

agggatgcag gatccccgcc ctggggtctg gtcctcgccc atcctgcagg gattgcccac   2100

cgtcttccag acaccccacc tgaggggggc accaggttta gtgctgctgc tttcactgct   2160

gcacccgcgc cctcggccgg ccccccgagc agcctttgta ctctgcttgc ggagggctgg   2220

gagaccctcc aggacattcc caccctcccc catgctgcca agttgtagct atagctacaa   2280

ataaaaaaaa accttgtttt ccagaaaaaa aaaaaaaaaa aaaaa                   2325


<210>  2146
<211>  572
<212>  PRT
<213>  Homosapiens

<400>  2146

Met Ala Ala Pro Arg Pro Ser Pro Ala Ile Ser Val Ser Val Ser Ala 
1               5                   10                  15      


Pro Ala Phe Tyr Ala Pro Gln Lys Lys Phe Gly Pro Val Val Ala Pro 
            20                  25                  30          


Lys Pro Lys Val Asn Pro Phe Arg Pro Gly Asp Ser Glu Pro Pro Pro 
        35                  40                  45              


Ala Pro Gly Ala Gln Arg Ala Gln Met Gly Arg Val Gly Glu Ile Pro 
    50                  55                  60                  


Pro Pro Pro Pro Glu Asp Phe Pro Leu Pro Pro Pro Pro Leu Ala Gly 
65                  70                  75                  80  


Asp Gly Asp Asp Ala Glu Gly Ala Leu Gly Gly Ala Phe Pro Pro Pro 
                85                  90                  95      


Pro Pro Pro Ile Glu Glu Ser Phe Pro Pro Ala Pro Leu Glu Glu Glu 
            100                 105                 110         


Ile Phe Pro Ser Pro Pro Pro Pro Pro Glu Glu Glu Gly Gly Pro Glu 
        115                 120                 125             


Ala Pro Ile Pro Pro Pro Pro Gln Pro Arg Glu Lys Val Ser Ser Ile 
    130                 135                 140                 


Asp Leu Glu Ile Asp Ser Leu Ser Ser Leu Leu Asp Asp Met Thr Lys 
145                 150                 155                 160 


Asn Asp Pro Phe Lys Ala Arg Val Ser Ser Gly Tyr Val Pro Pro Pro 
                165                 170                 175     


Val Ala Thr Pro Phe Ser Ser Lys Ser Ser Thr Lys Pro Ala Ala Gly 
            180                 185                 190         


Gly Thr Ala Pro Leu Pro Pro Trp Lys Ser Pro Ser Ser Ser Gln Pro 
        195                 200                 205             


Leu Pro Gln Val Pro Ala Pro Ala Gln Ser Gln Thr Gln Phe His Val 
    210                 215                 220                 


Gln Pro Gln Pro Gln Pro Lys Pro Gln Val Gln Leu His Val Gln Ser 
225                 230                 235                 240 


Gln Thr Gln Pro Val Ser Leu Ala Asn Thr Gln Pro Arg Gly Pro Pro 
                245                 250                 255     


Ala Ser Ser Pro Ala Pro Ala Pro Lys Phe Ser Pro Val Thr Pro Lys 
            260                 265                 270         


Phe Thr Pro Val Ala Ser Lys Phe Ser Pro Gly Ala Pro Gly Gly Ser 
        275                 280                 285             


Gly Ser Gln Pro Asn Gln Lys Leu Gly His Pro Glu Ala Leu Ser Ala 
    290                 295                 300                 


Gly Thr Gly Ser Pro Gln Pro Pro Ser Phe Thr Tyr Ala Gln Gln Arg 
305                 310                 315                 320 


Glu Lys Pro Arg Val Gln Glu Lys Gln His Pro Val Pro Pro Pro Ala 
                325                 330                 335     


Gln Asn Gln Asn Gln Val Arg Ser Pro Gly Ala Pro Gly Pro Leu Thr 
            340                 345                 350         


Leu Lys Glu Val Glu Glu Leu Glu Gln Leu Thr Gln Gln Leu Met Gln 
        355                 360                 365             


Asp Met Glu His Pro Gln Arg Gln Asn Val Ala Val Asn Glu Leu Cys 
    370                 375                 380                 


Gly Arg Cys His Gln Pro Leu Ala Arg Ala Gln Pro Ala Val Arg Ala 
385                 390                 395                 400 


Leu Gly Gln Leu Phe His Ile Ala Cys Phe Thr Cys His Gln Cys Ala 
                405                 410                 415     


Gln Gln Leu Gln Gly Gln Gln Phe Tyr Ser Leu Glu Gly Ala Pro Tyr 
            420                 425                 430         


Cys Glu Gly Cys Tyr Thr Asp Thr Leu Glu Lys Cys Asn Thr Cys Gly 
        435                 440                 445             


Glu Pro Ile Thr Asp Arg Met Leu Arg Ala Thr Gly Lys Ala Tyr His 
    450                 455                 460                 


Pro His Cys Phe Thr Cys Val Val Cys Ala Arg Pro Leu Glu Gly Thr 
465                 470                 475                 480 


Ser Phe Ile Val Asp Gln Ala Asn Arg Pro His Cys Val Pro Asp Tyr 
                485                 490                 495     


His Lys Gln Tyr Ala Pro Arg Cys Ser Val Cys Ser Glu Pro Ile Met 
            500                 505                 510         


Pro Glu Pro Gly Arg Asp Glu Thr Val Arg Val Val Ala Leu Asp Lys 
        515                 520                 525             


Asn Phe His Met Lys Cys Tyr Lys Cys Glu Asp Cys Gly Lys Pro Leu 
    530                 535                 540                 


Ser Ile Glu Ala Asp Asp Asn Gly Cys Phe Pro Leu Asp Gly His Val 
545                 550                 555                 560 


Leu Cys Arg Lys Cys His Thr Ala Arg Ala Gln Thr 
                565                 570         


<210>  2147
<211>  3367
<212>  DNA
<213>  Homosapiens

<400>  2147
gcccccgccc ggcccgcccc gctctcctag tcccttgcaa cctggcgctg ccatccgggc     60

cactgtccca ggtcccggcc cggagctatg gagcggcgct ggcccctggg gctagggctg    120

gtgctgctgc tctgcgcccc gctgcccccg ggggcgcgcg ccaaggaagt tactctgatg    180

gacacaagca aggcacaggg agagctgggc tggctgctgg atcccccaaa agatgggtgg    240

agtgaacagc aacagatact gaatgggaca cccctgtaca tgtaccagga ctgcccaatg    300

caaggacgca gagacactga ccactggctt cgctccaatt ggatctaccg cggggaggag    360

gcttcccgcg tccacgtgga gctgcagttc accgtgcggg actgcaagag tttccctggg    420

ggagccgggc ctctgggctg caaggagacc ttcaaccttc tgtacatgga gagtgaccag    480

gatgtgggca ttcagctccg acggcccttg ttccagaagg taaccacggt ggctgcagac    540

cagagcttca ccattcgaga ccttgcgtct ggctccgtga agctgaatgt ggagcgctgc    600

tctctgggcc gcctgacccg ccgtggcctc tacctcgctt tccacaaccc gggtgcctgt    660

gtggccctgg tgtctgtccg ggtcttctac cagcgctgtc ctgagaccct gaatggcttg    720

gcccaattcc cagacactct gcctggcccc gctgggttgg tggaagtggc ggggacctgc    780

ttgccccacg cgcgggccag ccccaggccc tcaggtgcac cccgcatgca ctgcagccct    840

gatggcgagt ggctggtgcc tgtaggacgg tgccactgtg agcctggcta tgaggaaggt    900

ggcagtggcg aagcatgtgt tgcctgccct agcggctcct accggatgga catggacaca    960

ccccattgtc tcacgtgccc ccagcagagc actgctgagt ctgagggggc caccatctgt   1020

acctgtgaga gcggccatta cagagctccc ggggagggcc cccaggtggc atgcacaggt   1080

cccccctcgg ccccccgaaa cctgagcttc tctgcctcag ggactcagct ctccctgcgt   1140

tgggaacccc cagcagatac ggggggacgc caggatgtca gatacagtgt gaggtgttcc   1200

cagtgtcagg gcacagcaca ggacgggggg ccctgccagc cctgtggggt gggcgtgcac   1260

ttctcgccgg gggcccgggg gctcaccaca cctgcagtgc atgtcaatgg ccttgaacct   1320

tatgccaact acacctttaa tgtggaagcc caaaatggag tgtcagggct gggcagctct   1380

ggccatgcca gcacctcagt cagcatcagc atggggcatg cagagtcact gtcaggcctg   1440

tctctgagac tggtgaagaa agaaccgagg caactagagc tgacctgggc ggggtcccgg   1500

ccccgaagcc ctggggcgaa cctgacctat gagctgcacg tgctgaacca ggatgaagaa   1560

cggtaccaga tggttctaga acccagggtc ttgctgacag agctgcagcc tgacaccaca   1620

tacatcgtca gagtccgaat gctgacccca ctgggtcctg gccctttctc ccctgatcat   1680

gagtttcgga ccagcccacc agtgtccagg ggcctgactg gaggagagat tgtagccgtc   1740

atctttgggc tgctgcttgg tgcagccttg ctgcttggga ttctcgtttt ccggtccagg   1800

agagcccagc ggcagaggca gcagaggcag cgtgaccgcg ccaccgatgt ggatcgagag   1860

gacaagctgt ggctgaagcc ttatgtggac ctccaggcat acgaggaccc tgcacaggga   1920

gccctggact ttacccggga gcttgatcca gcgtggctga tggtggacac tgtcatagga   1980

gaaggagagt ttggggaagt gtatcgaggg accctgaggc tccccagcca ggactgcaag   2040

actgtggcca ttaagacctt aaaagacaca tccccaggtg gccagtggtg gaacttcctt   2100

cgagaggcaa ctatcatggg ccagtttagc cacccgcata ttctgcatct ggaaggcgtc   2160

gtcacaaagc gaaagccgat catgatcatc acagaattta tggagaatgg agccctggat   2220

gccttcctga gggagcggga ggaccagctg gtccctgggc agctagtggc catgctgcag   2280

ggcatagcat ctggcatgaa ctacctcagt aatcacaatt atgtccaccg ggacctggct   2340

gccagaaaca tcttggtgaa tcaaaacctg tgctgcaagg tgtctgactt tggcctgact   2400

cgcctcctgg atgactttga tggcacatac gaaacccagg gaggaaagat ccctatccgt   2460

tggacagccc ctgaagccat tgcccatcgg atcttcacca cagccagcga tgtgtggagc   2520

tttgggattg tgatgtggga ggtgctgagc tttggggaca agccttatgg ggagatgagc   2580

aatcaggagg ttatgaagag cattgaggat gggtaccggt tgccccctcc tgtggactgc   2640

cctgcccctc tgtatgagct catgaagaac tgctgggcat atgaccgtgc ccgccggcca   2700

cacttccaga agcttcaggc acatctggag caactgcttg ccaaccccca ctccctgcgg   2760

accattgcca actttgaccc caggatgact cttcgcctgc ccagcctgag tggctcagat   2820

gggatcccat atcgaaccgt ctctgagtgg ctcgagtcca tacgcatgaa acgctacatc   2880

ctgcacttcc actcggctgg gctggacacc atggagtgtg tgctggagct gaccgctgag   2940

gacctgacgc agatgggaat cacactgccc gggcaccaga agcgcattct ttgcagtatt   3000

cagggattca aggactgatc cctcctctca ccccatgccc aatcagggtg caaggagcaa   3060

ggacggggcc aaggtcgctc atggtcactc cctgcgcccc ttcccacaac ctgccagact   3120

aggctatcgg tgctgcttct gcccactttc aggagaaccc tgctctgcac cccagaaaac   3180

ctctttgttt taaaagggag gtgggggtag aagtaaaagg atgatcatgg gagggagctg   3240

aggggttaat atatatacat acatacacat atatatattt ttgtaaataa acaggaactg   3300

attttctgcc tccatcccac ccatgagggc tgcaggcact acaaaagagc tgactactga   3360

gaaaaaa                                                             3367


<210>  2148
<211>  976
<212>  PRT
<213>  Homosapiens

<400>  2148

Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu Val Leu Leu Leu Cys 
1               5                   10                  15      


Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu Val Thr Leu Met Asp 
            20                  25                  30          


Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu Leu Asp Pro Pro Lys 
        35                  40                  45              


Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn Gly Thr Pro Leu Tyr 
    50                  55                  60                  


Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg Asp Thr Asp His Trp 
65                  70                  75                  80  


Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu Ala Ser Arg Val His 
                85                  90                  95      


Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys Ser Phe Pro Gly Gly 
            100                 105                 110         


Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn Leu Leu Tyr Met Glu 
        115                 120                 125             


Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg Pro Leu Phe Gln Lys 
    130                 135                 140                 


Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr Ile Arg Asp Leu Ala 
145                 150                 155                 160 


Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys Ser Leu Gly Arg Leu 
                165                 170                 175     


Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn Pro Gly Ala Cys Val 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg Cys Pro Glu Thr Leu 
        195                 200                 205             


Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro Gly Pro Ala Gly Leu 
    210                 215                 220                 


Val Glu Val Ala Gly Thr Cys Leu Pro His Ala Arg Ala Ser Pro Arg 
225                 230                 235                 240 


Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro Asp Gly Glu Trp Leu 
                245                 250                 255     


Val Pro Val Gly Arg Cys His Cys Glu Pro Gly Tyr Glu Glu Gly Gly 
            260                 265                 270         


Ser Gly Glu Ala Cys Val Ala Cys Pro Ser Gly Ser Tyr Arg Met Asp 
        275                 280                 285             


Met Asp Thr Pro His Cys Leu Thr Cys Pro Gln Gln Ser Thr Ala Glu 
    290                 295                 300                 


Ser Glu Gly Ala Thr Ile Cys Thr Cys Glu Ser Gly His Tyr Arg Ala 
305                 310                 315                 320 


Pro Gly Glu Gly Pro Gln Val Ala Cys Thr Gly Pro Pro Ser Ala Pro 
                325                 330                 335     


Arg Asn Leu Ser Phe Ser Ala Ser Gly Thr Gln Leu Ser Leu Arg Trp 
            340                 345                 350         


Glu Pro Pro Ala Asp Thr Gly Gly Arg Gln Asp Val Arg Tyr Ser Val 
        355                 360                 365             


Arg Cys Ser Gln Cys Gln Gly Thr Ala Gln Asp Gly Gly Pro Cys Gln 
    370                 375                 380                 


Pro Cys Gly Val Gly Val His Phe Ser Pro Gly Ala Arg Gly Leu Thr 
385                 390                 395                 400 


Thr Pro Ala Val His Val Asn Gly Leu Glu Pro Tyr Ala Asn Tyr Thr 
                405                 410                 415     


Phe Asn Val Glu Ala Gln Asn Gly Val Ser Gly Leu Gly Ser Ser Gly 
            420                 425                 430         


His Ala Ser Thr Ser Val Ser Ile Ser Met Gly His Ala Glu Ser Leu 
        435                 440                 445             


Ser Gly Leu Ser Leu Arg Leu Val Lys Lys Glu Pro Arg Gln Leu Glu 
    450                 455                 460                 


Leu Thr Trp Ala Gly Ser Arg Pro Arg Ser Pro Gly Ala Asn Leu Thr 
465                 470                 475                 480 


Tyr Glu Leu His Val Leu Asn Gln Asp Glu Glu Arg Tyr Gln Met Val 
                485                 490                 495     


Leu Glu Pro Arg Val Leu Leu Thr Glu Leu Gln Pro Asp Thr Thr Tyr 
            500                 505                 510         


Ile Val Arg Val Arg Met Leu Thr Pro Leu Gly Pro Gly Pro Phe Ser 
        515                 520                 525             


Pro Asp His Glu Phe Arg Thr Ser Pro Pro Val Ser Arg Gly Leu Thr 
    530                 535                 540                 


Gly Gly Glu Ile Val Ala Val Ile Phe Gly Leu Leu Leu Gly Ala Ala 
545                 550                 555                 560 


Leu Leu Leu Gly Ile Leu Val Phe Arg Ser Arg Arg Ala Gln Arg Gln 
                565                 570                 575     


Arg Gln Gln Arg Gln Arg Asp Arg Ala Thr Asp Val Asp Arg Glu Asp 
            580                 585                 590         


Lys Leu Trp Leu Lys Pro Tyr Val Asp Leu Gln Ala Tyr Glu Asp Pro 
        595                 600                 605             


Ala Gln Gly Ala Leu Asp Phe Thr Arg Glu Leu Asp Pro Ala Trp Leu 
    610                 615                 620                 


Met Val Asp Thr Val Ile Gly Glu Gly Glu Phe Gly Glu Val Tyr Arg 
625                 630                 635                 640 


Gly Thr Leu Arg Leu Pro Ser Gln Asp Cys Lys Thr Val Ala Ile Lys 
                645                 650                 655     


Thr Leu Lys Asp Thr Ser Pro Gly Gly Gln Trp Trp Asn Phe Leu Arg 
            660                 665                 670         


Glu Ala Thr Ile Met Gly Gln Phe Ser His Pro His Ile Leu His Leu 
        675                 680                 685             


Glu Gly Val Val Thr Lys Arg Lys Pro Ile Met Ile Ile Thr Glu Phe 
    690                 695                 700                 


Met Glu Asn Gly Ala Leu Asp Ala Phe Leu Arg Glu Arg Glu Asp Gln 
705                 710                 715                 720 


Leu Val Pro Gly Gln Leu Val Ala Met Leu Gln Gly Ile Ala Ser Gly 
                725                 730                 735     


Met Asn Tyr Leu Ser Asn His Asn Tyr Val His Arg Asp Leu Ala Ala 
            740                 745                 750         


Arg Asn Ile Leu Val Asn Gln Asn Leu Cys Cys Lys Val Ser Asp Phe 
        755                 760                 765             


Gly Leu Thr Arg Leu Leu Asp Asp Phe Asp Gly Thr Tyr Glu Thr Gln 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala His 
785                 790                 795                 800 


Arg Ile Phe Thr Thr Ala Ser Asp Val Trp Ser Phe Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Leu Ser Phe Gly Asp Lys Pro Tyr Gly Glu Met Ser Asn 
            820                 825                 830         


Gln Glu Val Met Lys Ser Ile Glu Asp Gly Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Val Asp Cys Pro Ala Pro Leu Tyr Glu Leu Met Lys Asn Cys Trp Ala 
    850                 855                 860                 


Tyr Asp Arg Ala Arg Arg Pro His Phe Gln Lys Leu Gln Ala His Leu 
865                 870                 875                 880 


Glu Gln Leu Leu Ala Asn Pro His Ser Leu Arg Thr Ile Ala Asn Phe 
                885                 890                 895     


Asp Pro Arg Met Thr Leu Arg Leu Pro Ser Leu Ser Gly Ser Asp Gly 
            900                 905                 910         


Ile Pro Tyr Arg Thr Val Ser Glu Trp Leu Glu Ser Ile Arg Met Lys 
        915                 920                 925             


Arg Tyr Ile Leu His Phe His Ser Ala Gly Leu Asp Thr Met Glu Cys 
    930                 935                 940                 


Val Leu Glu Leu Thr Ala Glu Asp Leu Thr Gln Met Gly Ile Thr Leu 
945                 950                 955                 960 


Pro Gly His Gln Lys Arg Ile Leu Cys Ser Ile Gln Gly Phe Lys Asp 
                965                 970                 975     


<210>  2149
<211>  957
<212>  DNA
<213>  Homosapiens

<400>  2149
atgaatggag accacatggt tctaggatct tcggtgactg acaagaaggc catcatcttg     60

gttaccattt tactcctttt acgcctggta gcaatagcag gcaatggctt catcactgct    120

gctctgggcg tggagtgggt gctacggaga atgttgttgc cttgtgataa gttattggtt    180

agcctagggg cctctcgctt ctgtctgcag tcagtggtaa tgggtaagac catttatgtt    240

ttcttgcatc cgatggcctt cccatacaac cctgtactgc agtttctagc tttccagtgg    300

gacttcctga atgctgccac cttatggtcc tctacctggc tcagtgtctt ctattgtgtg    360

aaaattgcta ccttcaccca ccctgtcttc ttctggctaa agcacaagtt gtctgggtgg    420

ctaccatgga tgctcttcag ctctgtaggg ctctccagct tcaccaccat tctatttttc    480

ataggcaacc acagaatgta tcagaactat ttaaggaacc atctacaacc ttggaatgtc    540

actggcgata gcatacggag ctactgtgag aaattctatc tcttccctct aaaaatgatt    600

acttggacaa tgcccactgc tgtctttttc atttgcatga ttttgctcat cacatctctg    660

ggaagacaca ggaagaaggc tctccttaca acctcaggat tccgagagcc cagtgtgcag    720

gcacacataa aggctctgct ggctctcctc tcttttgcca tgctcttcat ctcatatttc    780

ctgtcactgg tgttcagtgc tgcaggtatt tttccacctc tggactttaa attctgggtg    840

tgggagtcag tgatttatct gtgtgcagca gttcacccca tcattctgct cttcagcaac    900

tgcaggctga gagctgtgct gaagagtcgt cgttcctcaa ggtgtgggac accttga       957


<210>  2150
<211>  318
<212>  PRT
<213>  Homosapiens

<400>  2150

Met Asn Gly Asp His Met Val Leu Gly Ser Ser Val Thr Asp Lys Lys 
1               5                   10                  15      


Ala Ile Ile Leu Val Thr Ile Leu Leu Leu Leu Arg Leu Val Ala Ile 
            20                  25                  30          


Ala Gly Asn Gly Phe Ile Thr Ala Ala Leu Gly Val Glu Trp Val Leu 
        35                  40                  45              


Arg Arg Met Leu Leu Pro Cys Asp Lys Leu Leu Val Ser Leu Gly Ala 
    50                  55                  60                  


Ser Arg Phe Cys Leu Gln Ser Val Val Met Gly Lys Thr Ile Tyr Val 
65                  70                  75                  80  


Phe Leu His Pro Met Ala Phe Pro Tyr Asn Pro Val Leu Gln Phe Leu 
                85                  90                  95      


Ala Phe Gln Trp Asp Phe Leu Asn Ala Ala Thr Leu Trp Ser Ser Thr 
            100                 105                 110         


Trp Leu Ser Val Phe Tyr Cys Val Lys Ile Ala Thr Phe Thr His Pro 
        115                 120                 125             


Val Phe Phe Trp Leu Lys His Lys Leu Ser Gly Trp Leu Pro Trp Met 
    130                 135                 140                 


Leu Phe Ser Ser Val Gly Leu Ser Ser Phe Thr Thr Ile Leu Phe Phe 
145                 150                 155                 160 


Ile Gly Asn His Arg Met Tyr Gln Asn Tyr Leu Arg Asn His Leu Gln 
                165                 170                 175     


Pro Trp Asn Val Thr Gly Asp Ser Ile Arg Ser Tyr Cys Glu Lys Phe 
            180                 185                 190         


Tyr Leu Phe Pro Leu Lys Met Ile Thr Trp Thr Met Pro Thr Ala Val 
        195                 200                 205             


Phe Phe Ile Cys Met Ile Leu Leu Ile Thr Ser Leu Gly Arg His Arg 
    210                 215                 220                 


Lys Lys Ala Leu Leu Thr Thr Ser Gly Phe Arg Glu Pro Ser Val Gln 
225                 230                 235                 240 


Ala His Ile Lys Ala Leu Leu Ala Leu Leu Ser Phe Ala Met Leu Phe 
                245                 250                 255     


Ile Ser Tyr Phe Leu Ser Leu Val Phe Ser Ala Ala Gly Ile Phe Pro 
            260                 265                 270         


Pro Leu Asp Phe Lys Phe Trp Val Trp Glu Ser Val Ile Tyr Leu Cys 
        275                 280                 285             


Ala Ala Val His Pro Ile Ile Leu Leu Phe Ser Asn Cys Arg Leu Arg 
    290                 295                 300                 


Ala Val Leu Lys Ser Arg Arg Ser Ser Arg Cys Gly Thr Pro 
305                 310                 315             


<210>  2151
<211>  924
<212>  DNA
<213>  Homosapiens

<400>  2151
atgcaagcag cactgacggc cttcttcgtg ttgctcttta gcctgctgag tcttctgggg     60

attgcagcga atggcttcat tgtgctggtg ctgggcaggg agtggctgcg atatggcagg    120

ttgctgccct tggatatgat cctcattagc ttgggtgcct cccgcttctg cctgcagttg    180

gttgggacag tgcacaactt ctactactct gcccagaagg tcgagtactc tgggggtctc    240

ggccgacagt tcttccatct acactggcac ttcctgaact cagccacctt ctggttttgc    300

agctggctca gtgtcctgtt ctgtgtgaag attgctaaca tcacacactc caccttcctg    360

tggctgaagt ggaggttcct agggtgggtg ccctggctcc tgttgggctc tgtcctgatc    420

tccttcatca taaccctgct gtttttttgg gtgaactacc ctgtatatca agaattttta    480

attagaaaat tttctgggaa catgacctac aagtggaata caaggataga aacatactat    540

ttcccatccc tgaaactggt catctggtca attccttttt ctgtttttct ggtctcaatt    600

atgctgttaa ttaattctct gaggaggcat actcagagaa tgcagcacaa cgggcacagc    660

ctgcaggacc ccagcaccca ggctcacacc agagctctga agtccctcat ctccttcctc    720

attctttatg ctctgtcctt tctgtccctg atcattgatg ccgcaaaatt tatctccatg    780

cagaacgact tttactggcc atggcaaatt gcagtctacc tgtgcatatc tgtccatccc    840

ttcatcctca tcttcagcaa cctcaagctt cgaagcgtgt tctcacagct cctgttgttg    900

gcaaggggct tctgggtggc ctga                                           924


<210>  2152
<211>  307
<212>  PRT
<213>  Homosapiens

<400>  2152

Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu 
1               5                   10                  15      


Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly 
            20                  25                  30          


Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu 
        35                  40                  45              


Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val 
    50                  55                  60                  


His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu 
65                  70                  75                  80  


Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr 
                85                  90                  95      


Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala 
            100                 105                 110         


Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Leu Gly 
        115                 120                 125             


Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile 
    130                 135                 140                 


Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu 
145                 150                 155                 160 


Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile 
                165                 170                 175     


Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro 
            180                 185                 190         


Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg 
        195                 200                 205             


Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu 
225                 230                 235                 240 


Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys 
                245                 250                 255     


Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val 
            260                 265                 270         


Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu 
        275                 280                 285             


Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe 
    290                 295                 300                 


Trp Val Ala 
305         


<210>  2153
<211>  2355
<212>  DNA
<213>  Homosapiens

<400>  2153
cgccagagca gcctcgacgc tatggaggag cccggtgcta cccctcagcc ctacctgggg     60

ctggtcctgg aggagctacg cagagttgtg gcagcactac ctgagagtat gagaccagat    120

gagaatcctt atggttttcc atcggaactg gtggtatgtg cagctgttat tggatttttt    180

gttgttctcc tttttttgtg gagaagtttt agatcggtta ggagtcggct ttacgtggga    240

agagagcaaa aacttggtgc aacgctttct ggactaattg aagaaaaatg taaactactt    300

gaaaagttta gccttattca aaaagagtat gaaggctatg aagtagagtc atctttagag    360

gatgccagct ttgagaaggc ggcagcagaa gaagcacgaa gtttggaggc aacctgtgaa    420

aagctgaaca ggtccaattc tgaacttgag gatgaaatcc tctgtctaga aaaagactta    480

aaagaagaga aatctaaaca ttctcaacaa gatgaattga tggcggatat ttcaaaaagt    540

atacagtctc tagaagatga gtcaaaatcc ctcaaatcac aaatagctga agccaaaatc    600

atctgcaaga catttaaaat gagtgaagaa cgacgggcta tagcaataaa agatgctttg    660

aatgaaaatt ctcaacttca gacaagccat aaacagcttt ttcagcaaga agctgaagta    720

tggaaaggac aagtgagtga acttaataaa cagaaaataa catttgaaga ctccaaagta    780

cacgcagaac aagttctgaa tgataaagaa aatcacatca agaccctgac tggacacttg    840

ccaatgatga aagatcaggc tgctgtgctt gaagaagaca caacggatga tgataacctg    900

gaattagaag tgaacagtca atgggaaaat ggtgctaact tagatgatcc tctgaaagga    960

gctttgaaga aactgattca tgctgctaag ttaaatgttt ctttaaaaag cttagaagga   1020

gaaagaaacc acattattat tcagttatct gaagtggaca aaacaaagga agagcttaca   1080

gagcatatta aaaatcttca gactcaacaa gcatctttgc aatcagaaaa catatatttt   1140

gaaagtgaga atcagaagct tcaacagaaa cttaaaataa tgactgaatt ctatcaagaa   1200

aatgaaatga aactctacag gaaattaaca gtggaggaaa attaccgaat agaggaagaa   1260

gagaagcttt ctagagtgga agaaaagctc agccgtgcca ctgaacagct ggagacctat   1320

agaaagctag ccaaagatct tgaagaagaa ttggagagaa ctgttcattt ttatcaaaag   1380

caggttattt cctacgagaa aagaggacat gataattggt tggcagctcg gactgctgaa   1440

agaaacctca gtgatttaag gaaagaaaat gctcacaaca aacaaaaatt aactgaaaca   1500

gagttgaaat ttgaactttt agaaaaagat cctaatgcac ttgatgtttc aaatacagca   1560

tttggcagag agcatgcccc gaatggtccc gcaccattgg gtcagcgttc atctgaaacg   1620

agagcttttc tctctcctca aactttgttg gaggatccac tgggactctc acctgtgctt   1680

ccggagggag gaggaagagg cccaagaggc ccagggaatc ccctggacca tcagattacc   1740

aatgaaagag gagaaccaag ctgtgacagg ttaaccgatc ctcacagggc tccttctgac   1800

actgggtccc tgtcatctcc ggtggaacag gactgtaaga tgatgtttcc tccaccagga   1860

caatcatatc ctgattcagc tcttcctcct caaagggaag acagatttta ttctaattct   1920

gaaagactgt ctggatcagc agaacccaga agttttaaaa tgacttcttt ggataaaatg   1980

gatgggtcaa tgccttcaga aatggaatcc agtagaaatg atgccaaaga tgatcttggt   2040

aatttaaatg tgcctgattc atctctccct gctgaaaatg aagcaactgg ccctggcttt   2100

attcctccac ctcttgctcc agtcagagga ccattgtttc cagtggatac aaggggcccg   2160

ttcatgagaa gaggacctcc tttcccccca cctcctccag gaaccatgtt tggagcttct   2220

cgaggttatt ttccaccaag ggatttccca ggtccaccac atgctccatt tgcaatgaga   2280

aacatctacc caccgagggg tttacctcct tactttcacc cgagacctgg attttacccc   2340

aaccccgcat tctga                                                    2355


<210>  2154
<211>  777
<212>  PRT
<213>  Homosapiens

<400>  2154

Met Glu Glu Pro Gly Ala Thr Pro Gln Pro Tyr Leu Gly Leu Val Leu 
1               5                   10                  15      


Glu Glu Leu Arg Arg Val Val Ala Ala Leu Pro Glu Ser Met Arg Pro 
            20                  25                  30          


Asp Glu Asn Pro Tyr Gly Phe Pro Ser Glu Leu Val Val Cys Ala Ala 
        35                  40                  45              


Val Ile Gly Phe Phe Val Val Leu Leu Phe Leu Trp Arg Ser Phe Arg 
    50                  55                  60                  


Ser Val Arg Ser Arg Leu Tyr Val Gly Arg Glu Gln Lys Leu Gly Ala 
65                  70                  75                  80  


Thr Leu Ser Gly Leu Ile Glu Glu Lys Cys Lys Leu Leu Glu Lys Phe 
                85                  90                  95      


Ser Leu Ile Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu Ser Ser Leu 
            100                 105                 110         


Glu Asp Ala Ser Phe Glu Lys Ala Ala Ala Glu Glu Ala Arg Ser Leu 
        115                 120                 125             


Glu Ala Thr Cys Glu Lys Leu Asn Arg Ser Asn Ser Glu Leu Glu Asp 
    130                 135                 140                 


Glu Ile Leu Cys Leu Glu Lys Asp Leu Lys Glu Glu Lys Ser Lys His 
145                 150                 155                 160 


Ser Gln Gln Asp Glu Leu Met Ala Asp Ile Ser Lys Ser Ile Gln Ser 
                165                 170                 175     


Leu Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Ile Ala Glu Ala Lys 
            180                 185                 190         


Ile Ile Cys Lys Thr Phe Lys Met Ser Glu Glu Arg Arg Ala Ile Ala 
        195                 200                 205             


Ile Lys Asp Ala Leu Asn Glu Asn Ser Gln Leu Gln Thr Ser His Lys 
    210                 215                 220                 


Gln Leu Phe Gln Gln Glu Ala Glu Val Trp Lys Gly Gln Val Ser Glu 
225                 230                 235                 240 


Leu Asn Lys Gln Lys Ile Thr Phe Glu Asp Ser Lys Val His Ala Glu 
                245                 250                 255     


Gln Val Leu Asn Asp Lys Glu Asn His Ile Lys Thr Leu Thr Gly His 
            260                 265                 270         


Leu Pro Met Met Lys Asp Gln Ala Ala Val Leu Glu Glu Asp Thr Thr 
        275                 280                 285             


Asp Asp Asp Asn Leu Glu Leu Glu Val Asn Ser Gln Trp Glu Asn Gly 
    290                 295                 300                 


Ala Asn Leu Asp Asp Pro Leu Lys Gly Ala Leu Lys Lys Leu Ile His 
305                 310                 315                 320 


Ala Ala Lys Leu Asn Val Ser Leu Lys Ser Leu Glu Gly Glu Arg Asn 
                325                 330                 335     


His Ile Ile Ile Gln Leu Ser Glu Val Asp Lys Thr Lys Glu Glu Leu 
            340                 345                 350         


Thr Glu His Ile Lys Asn Leu Gln Thr Gln Gln Ala Ser Leu Gln Ser 
        355                 360                 365             


Glu Asn Ile Tyr Phe Glu Ser Glu Asn Gln Lys Leu Gln Gln Lys Leu 
    370                 375                 380                 


Lys Ile Met Thr Glu Phe Tyr Gln Glu Asn Glu Met Lys Leu Tyr Arg 
385                 390                 395                 400 


Lys Leu Thr Val Glu Glu Asn Tyr Arg Ile Glu Glu Glu Glu Lys Leu 
                405                 410                 415     


Ser Arg Val Glu Glu Lys Leu Ser Arg Ala Thr Glu Gln Leu Glu Thr 
            420                 425                 430         


Tyr Arg Lys Leu Ala Lys Asp Leu Glu Glu Glu Leu Glu Arg Thr Val 
        435                 440                 445             


His Phe Tyr Gln Lys Gln Val Ile Ser Tyr Glu Lys Arg Gly His Asp 
    450                 455                 460                 


Asn Trp Leu Ala Ala Arg Thr Ala Glu Arg Asn Leu Ser Asp Leu Arg 
465                 470                 475                 480 


Lys Glu Asn Ala His Asn Lys Gln Lys Leu Thr Glu Thr Glu Leu Lys 
                485                 490                 495     


Phe Glu Leu Leu Glu Lys Asp Pro Asn Ala Leu Asp Val Ser Asn Thr 
            500                 505                 510         


Ala Phe Gly Arg Glu His Ala Pro Asn Gly Pro Ala Pro Leu Gly Gln 
        515                 520                 525             


Arg Ser Ser Glu Thr Arg Ala Phe Leu Ser Pro Gln Thr Leu Leu Glu 
    530                 535                 540                 


Asp Pro Leu Gly Leu Ser Pro Val Leu Pro Glu Gly Gly Gly Arg Gly 
545                 550                 555                 560 


Pro Arg Gly Pro Gly Asn Pro Leu Asp His Gln Ile Thr Asn Glu Arg 
                565                 570                 575     


Gly Glu Pro Ser Cys Asp Arg Leu Thr Asp Pro His Arg Ala Pro Ser 
            580                 585                 590         


Asp Thr Gly Ser Leu Ser Ser Pro Val Glu Gln Asp Cys Lys Met Met 
        595                 600                 605             


Phe Pro Pro Pro Gly Gln Ser Tyr Pro Asp Ser Ala Leu Pro Pro Gln 
    610                 615                 620                 


Arg Glu Asp Arg Phe Tyr Ser Asn Ser Glu Arg Leu Ser Gly Ser Ala 
625                 630                 635                 640 


Glu Pro Arg Ser Phe Lys Met Thr Ser Leu Asp Lys Met Asp Gly Ser 
                645                 650                 655     


Met Pro Ser Glu Met Glu Ser Ser Arg Asn Asp Ala Lys Asp Asp Leu 
            660                 665                 670         


Gly Asn Leu Asn Val Pro Asp Ser Ser Leu Pro Ala Glu Asn Glu Ala 
        675                 680                 685             


Thr Gly Pro Gly Phe Ile Pro Pro Pro Leu Ala Pro Val Arg Gly Pro 
    690                 695                 700                 


Leu Phe Pro Val Asp Thr Arg Gly Pro Phe Met Arg Arg Gly Pro Pro 
705                 710                 715                 720 


Phe Pro Pro Pro Pro Pro Gly Thr Met Phe Gly Ala Ser Arg Gly Tyr 
                725                 730                 735     


Phe Pro Pro Arg Asp Phe Pro Gly Pro Pro His Ala Pro Phe Ala Met 
            740                 745                 750         


Arg Asn Ile Tyr Pro Pro Arg Gly Leu Pro Pro Tyr Phe His Pro Arg 
        755                 760                 765             


Pro Gly Phe Tyr Pro Asn Pro Ala Phe 
    770                 775         


<210>  2155
<211>  2955
<212>  DNA
<213>  Homosapiens

<400>  2155
ggatctctct cggctgcttt tttccactgg taacttctga ggctgagatc agcagctgat     60

agaaccatgg cgaccattgc tgctgctgcg tttgaggccc tcatggatgg agtgacatgc    120

tgggatgtcc ccagaggccc catccccagt gaactccttc ttattggaga agccgccttc    180

cccgtgatgg tgaatgacaa gggccaggtg ctcattgctg cctcctccta cggccgaggc    240

cgcctcgtgg ttgtgtccca tgagggctac ctgtcgcatg ctggcttggc tccatttctc    300

ctcaatgcag tgagctggct ctgtccctgt cctggggctc ccgtgggagt gcatccatcc    360

ctggcacctc tagtaaacat cctacaggat gctgggcttg aggcacaggt caagccagaa    420

ccaggagagc ccctaggggt ttactgtatc aatgcctaca atgacacctt gactgcaacg    480

ctgatccagt ttgtgaaaca tggagggggc ttgttaatcg ggggccaggc ctggtactgg    540

gccagccagc acggccctga caaggtgctc tccaggttcc ctgggaacaa ggtgacaagt    600

gtagccggag tgtacttcac tgacacctat ggggacagag accggttcaa ggtctctaag    660

aaggtgccca agatcccact ccatgtcagg tatggggagg atgtcaggca ggaccagcag    720

cagctcctgg aggggatctc agagctggac atcaggacag ggggagtccc ctcacagctg    780

cttgtacatg gagccctggc cttccctctg gggctggatg cctcactcaa ctgcttcctg    840

gcggctgctc actatggccg gggccgggtg gtcctggctg cccacgagtg cctgctctgt    900

gctcccaaga tggggccctt cttgctcaat gcggtgcgct ggctggccag aggccagaca    960

ggcaaagttg gggtgaacac aaatctaaaa gatctgtgtc ctctcctatc ggagcatggc   1020

ctgcaatgca gcctggagcc ccatctgaac agcgacttgt gtgtctactg ctgcaaggcg   1080

tacagtgaca aggaggctaa gcagctgcag gagtttgtgg ctgagggtgg ggggctgctg   1140

attgggggcc aggcctggtg gtgggcctcc cagaaccctg gccactgccc cttggctggc   1200

ttccctggta acatcatcct caactgcttt ggcctcagca tcctgcctca gactctcaaa   1260

gcaggctgct tccccgttcc cacccctgag atgagaagct accacttccg caaggcgctc   1320

tctcaattcc aggctatact gaaccacgag aatgggaact tggaaaagag ctgtctggca   1380

aagttgagag ttgatggtgc agccttccta cagattcctg cggagggggt ccctgcttac   1440

atatccctgc acaggctcct gaggaagatg ctacgagggt ctggcctccc agctgtgagc   1500

cgggaaaatc cagttgccag tgactcctat gaggctgcgg tgctctccct ggccactggg   1560

ctggctcact ctggaactga ctgctcccag ctggcccagg ggcttggcac ctggacctgc   1620

tcctccagtt tgtacccctc aaaacacccc atcaccgtgg agatcaatgg aatcaaccca   1680

ggcaacaatg attgctgggt gagtaccggg ctctacctcc tggaaggaca aaatgcagaa   1740

gtctcactgt ctgaagctgc tgcctctgct ggcctgaggg tacagatagg ctgccacacc   1800

gatgacctta ccaaggccag gaagctatct cgagcccccg tggtgactca ccaatgctgg   1860

atggacagga ctgagcggtc agtctcctgc ctctggggcg gcctcctcta cgtcatcgtg   1920

cccaagggca gccaactagg ccctgtgcct gtcactatca ggggagctgt gcctgcccca   1980

tactacaagc tgggtaagac atcgctggag gagtggaaga ggcagatgca ggagaacctg   2040

gctccctggg gagagctggc cacggacaac atcatcctga cagtgccaac cacaaacctt   2100

caggccctga aggaccccga gcctgtgctc cgcctctggg atgagatgat gcaggctgtg   2160

gccaggctgg cggctgagcc cttccctttc cgccgtcctg agaggattgt ggctgatgtg   2220

cagatctcag ctggctggat gcattcagga taccccatca tgtgccacct ggagtctgtg   2280

aaggagatca tcaatgagat ggacatgagg agcaggggtg tgtggggccc catccatgag   2340

ctgggccaca accaacagcg gcatggatgg gagttccccc cacacactac tgaggccacc   2400

tgtaaccttt ggtcagtcta cgtgcatgaa acagtcctgg ggatccccag ggctcaggcc   2460

cacgaggctc tgagccctcc agagcgggag aggagaatca aggcccacct gggaaaggga   2520

gcccccctgt gtgactggaa tgtatggaca gccctggaaa catatctaca ggtactgagc   2580

agaaattctg ggagaagggg atgaccagac ccctcagtca tgtagcgacc tggatcccag   2640

tagccctcca cctccttcgc cactccacca gcctggacct ccacctcccc tggaaatgag   2700

agggactggg ccgcagggtg gtgcttcttg ggttataccc ctctaaggca gagagaatgg   2760

cacctgtctc actcaccttc tgattttgca atgtaagagg aaatgaaaaa tattatgaaa   2820

aaaatagaaa tatagcatat tattcaaggg cagaaactct gttagacatt cctgcagctg   2880

aatcacagct cttgccctca ttggttttgt tcttggtctc ctaataagtg ttccataaat   2940

ggtcattgct ttgtt                                                    2955


<210>  2156
<211>  845
<212>  PRT
<213>  Homosapiens

<400>  2156

Met Ala Thr Ile Ala Ala Ala Ala Phe Glu Ala Leu Met Asp Gly Val 
1               5                   10                  15      


Thr Cys Trp Asp Val Pro Arg Gly Pro Ile Pro Ser Glu Leu Leu Leu 
            20                  25                  30          


Ile Gly Glu Ala Ala Phe Pro Val Met Val Asn Asp Lys Gly Gln Val 
        35                  40                  45              


Leu Ile Ala Ala Ser Ser Tyr Gly Arg Gly Arg Leu Val Val Val Ser 
    50                  55                  60                  


His Glu Gly Tyr Leu Ser His Ala Gly Leu Ala Pro Phe Leu Leu Asn 
65                  70                  75                  80  


Ala Val Ser Trp Leu Cys Pro Cys Pro Gly Ala Pro Val Gly Val His 
                85                  90                  95      


Pro Ser Leu Ala Pro Leu Val Asn Ile Leu Gln Asp Ala Gly Leu Glu 
            100                 105                 110         


Ala Gln Val Lys Pro Glu Pro Gly Glu Pro Leu Gly Val Tyr Cys Ile 
        115                 120                 125             


Asn Ala Tyr Asn Asp Thr Leu Thr Ala Thr Leu Ile Gln Phe Val Lys 
    130                 135                 140                 


His Gly Gly Gly Leu Leu Ile Gly Gly Gln Ala Trp Tyr Trp Ala Ser 
145                 150                 155                 160 


Gln His Gly Pro Asp Lys Val Leu Ser Arg Phe Pro Gly Asn Lys Val 
                165                 170                 175     


Thr Ser Val Ala Gly Val Tyr Phe Thr Asp Thr Tyr Gly Asp Arg Asp 
            180                 185                 190         


Arg Phe Lys Val Ser Lys Lys Val Pro Lys Ile Pro Leu His Val Arg 
        195                 200                 205             


Tyr Gly Glu Asp Val Arg Gln Asp Gln Gln Gln Leu Leu Glu Gly Ile 
    210                 215                 220                 


Ser Glu Leu Asp Ile Arg Thr Gly Gly Val Pro Ser Gln Leu Leu Val 
225                 230                 235                 240 


His Gly Ala Leu Ala Phe Pro Leu Gly Leu Asp Ala Ser Leu Asn Cys 
                245                 250                 255     


Phe Leu Ala Ala Ala His Tyr Gly Arg Gly Arg Val Val Leu Ala Ala 
            260                 265                 270         


His Glu Cys Leu Leu Cys Ala Pro Lys Met Gly Pro Phe Leu Leu Asn 
        275                 280                 285             


Ala Val Arg Trp Leu Ala Arg Gly Gln Thr Gly Lys Val Gly Val Asn 
    290                 295                 300                 


Thr Asn Leu Lys Asp Leu Cys Pro Leu Leu Ser Glu His Gly Leu Gln 
305                 310                 315                 320 


Cys Ser Leu Glu Pro His Leu Asn Ser Asp Leu Cys Val Tyr Cys Cys 
                325                 330                 335     


Lys Ala Tyr Ser Asp Lys Glu Ala Lys Gln Leu Gln Glu Phe Val Ala 
            340                 345                 350         


Glu Gly Gly Gly Leu Leu Ile Gly Gly Gln Ala Trp Trp Trp Ala Ser 
        355                 360                 365             


Gln Asn Pro Gly His Cys Pro Leu Ala Gly Phe Pro Gly Asn Ile Ile 
    370                 375                 380                 


Leu Asn Cys Phe Gly Leu Ser Ile Leu Pro Gln Thr Leu Lys Ala Gly 
385                 390                 395                 400 


Cys Phe Pro Val Pro Thr Pro Glu Met Arg Ser Tyr His Phe Arg Lys 
                405                 410                 415     


Ala Leu Ser Gln Phe Gln Ala Ile Leu Asn His Glu Asn Gly Asn Leu 
            420                 425                 430         


Glu Lys Ser Cys Leu Ala Lys Leu Arg Val Asp Gly Ala Ala Phe Leu 
        435                 440                 445             


Gln Ile Pro Ala Glu Gly Val Pro Ala Tyr Ile Ser Leu His Arg Leu 
    450                 455                 460                 


Leu Arg Lys Met Leu Arg Gly Ser Gly Leu Pro Ala Val Ser Arg Glu 
465                 470                 475                 480 


Asn Pro Val Ala Ser Asp Ser Tyr Glu Ala Ala Val Leu Ser Leu Ala 
                485                 490                 495     


Thr Gly Leu Ala His Ser Gly Thr Asp Cys Ser Gln Leu Ala Gln Gly 
            500                 505                 510         


Leu Gly Thr Trp Thr Cys Ser Ser Ser Leu Tyr Pro Ser Lys His Pro 
        515                 520                 525             


Ile Thr Val Glu Ile Asn Gly Ile Asn Pro Gly Asn Asn Asp Cys Trp 
    530                 535                 540                 


Val Ser Thr Gly Leu Tyr Leu Leu Glu Gly Gln Asn Ala Glu Val Ser 
545                 550                 555                 560 


Leu Ser Glu Ala Ala Ala Ser Ala Gly Leu Arg Val Gln Ile Gly Cys 
                565                 570                 575     


His Thr Asp Asp Leu Thr Lys Ala Arg Lys Leu Ser Arg Ala Pro Val 
            580                 585                 590         


Val Thr His Gln Cys Trp Met Asp Arg Thr Glu Arg Ser Val Ser Cys 
        595                 600                 605             


Leu Trp Gly Gly Leu Leu Tyr Val Ile Val Pro Lys Gly Ser Gln Leu 
    610                 615                 620                 


Gly Pro Val Pro Val Thr Ile Arg Gly Ala Val Pro Ala Pro Tyr Tyr 
625                 630                 635                 640 


Lys Leu Gly Lys Thr Ser Leu Glu Glu Trp Lys Arg Gln Met Gln Glu 
                645                 650                 655     


Asn Leu Ala Pro Trp Gly Glu Leu Ala Thr Asp Asn Ile Ile Leu Thr 
            660                 665                 670         


Val Pro Thr Thr Asn Leu Gln Ala Leu Lys Asp Pro Glu Pro Val Leu 
        675                 680                 685             


Arg Leu Trp Asp Glu Met Met Gln Ala Val Ala Arg Leu Ala Ala Glu 
    690                 695                 700                 


Pro Phe Pro Phe Arg Arg Pro Glu Arg Ile Val Ala Asp Val Gln Ile 
705                 710                 715                 720 


Ser Ala Gly Trp Met His Ser Gly Tyr Pro Ile Met Cys His Leu Glu 
                725                 730                 735     


Ser Val Lys Glu Ile Ile Asn Glu Met Asp Met Arg Ser Arg Gly Val 
            740                 745                 750         


Trp Gly Pro Ile His Glu Leu Gly His Asn Gln Gln Arg His Gly Trp 
        755                 760                 765             


Glu Phe Pro Pro His Thr Thr Glu Ala Thr Cys Asn Leu Trp Ser Val 
    770                 775                 780                 


Tyr Val His Glu Thr Val Leu Gly Ile Pro Arg Ala Gln Ala His Glu 
785                 790                 795                 800 


Ala Leu Ser Pro Pro Glu Arg Glu Arg Arg Ile Lys Ala His Leu Gly 
                805                 810                 815     


Lys Gly Ala Pro Leu Cys Asp Trp Asn Val Trp Thr Ala Leu Glu Thr 
            820                 825                 830         


Tyr Leu Gln Val Leu Ser Arg Asn Ser Gly Arg Arg Gly 
        835                 840                 845 


<210>  2157
<211>  3172
<212>  DNA
<213>  Homosapiens

<400>  2157
taattcattt aattatgaat ggtctaccaa gagacagata atagaagagt gtatgtaaaa     60

gtatgaccct ttcttatatg tttcttgcat gctgtgtaca agaaactcac ttgaaattta    120

ccaatacagg gcaggccaaa ttaacaggat gaaaaaagat atattacaca aacattaatg    180

aaaggaaagc aagagtgcct gtatgtatat cagataaagc aaagaaaatt accagaaaca    240

gattatataa tgatcaaagg tttaattcat gaagaagaca gcaattttaa aagtgtattc    300

accaaaaaat aaagcttcaa aatatgtgat gtgaaaactg ccagaactaa ggcgggccgg    360

gctcagacca gcgctgcctc aggatgtgaa gtgtaacaag agggccaggg gaggtggtgg    420

gggacaacat gggcctgtga ggcctgtggg tgcccgcgtt ccccagctcc ccccgcagcc    480

cgctccacag tggtccgctc cggttggttg tcacgtgcgc attcgggttc cagacccaag    540

gctgcgtgtt ctccaccgct tgttgtggcc agtgttactg cggtgaccgc cagagcagcc    600

tcgacgctat ggaggagcct ggtgctaccc ctcagcccta cctggggctg gtcctggagg    660

agctacgcag agttgtggca gcactacctg agagtatgag accagatgag aatccttatg    720

gttttccatc ggaactggtg gtatgtgcag ctgttattgg attttttgtt gttctccttt    780

ttttgtggag aagttttaga tcggttagga gtcggcttta cgtgggaaga gagcaaaaac    840

ttggtgcaac gctttctgga ctaattgaag aaaaatgtaa actacttgaa aagtttagcc    900

ttattcaaaa agagtatgaa ggctatgaag tagagtcatc tttagaggat gccagctttg    960

agaaggcggc agcagaagaa gcacgaagtt tggaggcaac ctgtgaaaag ctgaacaggt   1020

ccaattctga acttgaggat gaaatcctct gtctagaaaa agacttaaaa gaagagaaat   1080

ctaaacattc tcaacaagat gaattgatgg cggatatttc aaaaagtata cagtctctag   1140

aagatgagtc aaaatccctc aaatcacaaa tagctgaagc caaaatcatc tgcaagacat   1200

ttaaaatgag tgaagaacga cgggctatag caataaaaga tgctttgaat gaaaattctc   1260

aacttcagac aagccataaa cagctttttc agcaagaagc tgaagtatgg aaaggagaag   1320

tgagtgaact taataaacag aaaataacat ttgaagactc caaagtacac gcagaacaag   1380

ttctgaatga taaagaaaat cacatcaaga ccctgactgg acacttgcca atgatgaaag   1440

atcaggctgc tgtgcttgaa gaagacacaa cggatgatga taacctggaa ttagaagtga   1500

acagtcaatg ggaaaatggt gctaacttag atgatcctct gaaaggagct ttgaagaaac   1560

tgattcatgc tgctaagtta aatgtttctt taaaaagctt agaaggagaa agaaaccaca   1620

ttattattca gttatctgaa gtggacaaaa caaaggaaga gcttacagag catattaaaa   1680

atcttcagac tcaacaagaa tctttgcaat cagaaaacat atattttgaa agtgagaatc   1740

agaagcttca acagaaactt aaaataatga ctgaattcta tcaagaagat gaaatgaaac   1800

tctataggaa attaacagtg gaggaaaatt accgaataga ggaagaagag aagctttcta   1860

aagtggaaga aaagctcagc cgtgccactg aacagctgga gacctataga aagctagcca   1920

aagatcttga agaagaattg gagagaactg ttcattttta tcaaaagcag gttatttcct   1980

acgagaaaag aggacatgat aattggttgg cagctcggac tgctgaaaga aacctcagtg   2040

atttaaggaa agaaaatgct cacaacaaac aaaaattaac tgaaacagag ttgaaatttg   2100

aacttttaga aaaagatcct aatgcacttg atgtttcaaa tacagcattt ggcagagagc   2160

atgccccgaa tggtcccgca ccattgggtc agcgttcatc tgaaacgaga gcttttctct   2220

ctcctcaaac tttgttggag gatccactgg gactctcacc tgtgcttccg gagggaggag   2280

gaagaggccc aagaggccca gggaatcccc tggaccatca gattaccaat gaaagaggag   2340

aaccaagctg tgacaggtta accgatcctc acagggctcc ttctgacact gggtccctgt   2400

catctccggt ggaacaggac tgtaagatga tgtttcctcc accaggacaa tcatatcctg   2460

attcagctct tcctcctcaa agggaagaca gattttattc taattctgaa agactgtctg   2520

gatcagcaga acccagaagt tttaaaatga cttctttgga taaaatggat gggtcaatgc   2580

cttcagaaat ggaatccagt agaaatgatg ccaaagatga tcttggtaat ttaaatgtgc   2640

ctgattcatc tctccctgct gaaaatgaag caactggccc tggctttatt cctccacctc   2700

ttgctccagt cagaggacca ttgtttccag tggatacaag gggcccgttc atgagaagag   2760

gacctccttt ccccccacct cctccaggaa ccatgtttgg agcttctcga ggttattttc   2820

caccaaggga tttcccaggt ccaccacatg ctccatttgc aatgagaaac atctacccac   2880

cgaggggttt acctccttac tttcacccga gacctggatt ttaccccaac cccgcattct   2940

gaaggtagaa gcgagttccc ttcaggattg attccgcctt taatgctact gaacatccag   3000

gaccacaaaa gaaacctgac aatattgttg ctttcttcaa aagtaatttt gactgatctc   3060

attttcagtt taagtaactg ctattactta agtgattgca cttttgctca aattgaagtt   3120

taatggaatt ataattctca ggatagtatt ttgtaaataa agatgtttta aa           3172


<210>  2158
<211>  777
<212>  PRT
<213>  Homosapiens

<400>  2158

Met Glu Glu Pro Gly Ala Thr Pro Gln Pro Tyr Leu Gly Leu Val Leu 
1               5                   10                  15      


Glu Glu Leu Arg Arg Val Val Ala Ala Leu Pro Glu Ser Met Arg Pro 
            20                  25                  30          


Asp Glu Asn Pro Tyr Gly Phe Pro Ser Glu Leu Val Val Cys Ala Ala 
        35                  40                  45              


Val Ile Gly Phe Phe Val Val Leu Leu Phe Leu Trp Arg Ser Phe Arg 
    50                  55                  60                  


Ser Val Arg Ser Arg Leu Tyr Val Gly Arg Glu Gln Lys Leu Gly Ala 
65                  70                  75                  80  


Thr Leu Ser Gly Leu Ile Glu Glu Lys Cys Lys Leu Leu Glu Lys Phe 
                85                  90                  95      


Ser Leu Ile Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu Ser Ser Leu 
            100                 105                 110         


Glu Asp Ala Ser Phe Glu Lys Ala Ala Ala Glu Glu Ala Arg Ser Leu 
        115                 120                 125             


Glu Ala Thr Cys Glu Lys Leu Asn Arg Ser Asn Ser Glu Leu Glu Asp 
    130                 135                 140                 


Glu Ile Leu Cys Leu Glu Lys Asp Leu Lys Glu Glu Lys Ser Lys His 
145                 150                 155                 160 


Ser Gln Gln Asp Glu Leu Met Ala Asp Ile Ser Lys Ser Ile Gln Ser 
                165                 170                 175     


Leu Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Ile Ala Glu Ala Lys 
            180                 185                 190         


Ile Ile Cys Lys Thr Phe Lys Met Ser Glu Glu Arg Arg Ala Ile Ala 
        195                 200                 205             


Ile Lys Asp Ala Leu Asn Glu Asn Ser Gln Leu Gln Thr Ser His Lys 
    210                 215                 220                 


Gln Leu Phe Gln Gln Glu Ala Glu Val Trp Lys Gly Glu Val Ser Glu 
225                 230                 235                 240 


Leu Asn Lys Gln Lys Ile Thr Phe Glu Asp Ser Lys Val His Ala Glu 
                245                 250                 255     


Gln Val Leu Asn Asp Lys Glu Asn His Ile Lys Thr Leu Thr Gly His 
            260                 265                 270         


Leu Pro Met Met Lys Asp Gln Ala Ala Val Leu Glu Glu Asp Thr Thr 
        275                 280                 285             


Asp Asp Asp Asn Leu Glu Leu Glu Val Asn Ser Gln Trp Glu Asn Gly 
    290                 295                 300                 


Ala Asn Leu Asp Asp Pro Leu Lys Gly Ala Leu Lys Lys Leu Ile His 
305                 310                 315                 320 


Ala Ala Lys Leu Asn Val Ser Leu Lys Ser Leu Glu Gly Glu Arg Asn 
                325                 330                 335     


His Ile Ile Ile Gln Leu Ser Glu Val Asp Lys Thr Lys Glu Glu Leu 
            340                 345                 350         


Thr Glu His Ile Lys Asn Leu Gln Thr Gln Gln Glu Ser Leu Gln Ser 
        355                 360                 365             


Glu Asn Ile Tyr Phe Glu Ser Glu Asn Gln Lys Leu Gln Gln Lys Leu 
    370                 375                 380                 


Lys Ile Met Thr Glu Phe Tyr Gln Glu Asp Glu Met Lys Leu Tyr Arg 
385                 390                 395                 400 


Lys Leu Thr Val Glu Glu Asn Tyr Arg Ile Glu Glu Glu Glu Lys Leu 
                405                 410                 415     


Ser Lys Val Glu Glu Lys Leu Ser Arg Ala Thr Glu Gln Leu Glu Thr 
            420                 425                 430         


Tyr Arg Lys Leu Ala Lys Asp Leu Glu Glu Glu Leu Glu Arg Thr Val 
        435                 440                 445             


His Phe Tyr Gln Lys Gln Val Ile Ser Tyr Glu Lys Arg Gly His Asp 
    450                 455                 460                 


Asn Trp Leu Ala Ala Arg Thr Ala Glu Arg Asn Leu Ser Asp Leu Arg 
465                 470                 475                 480 


Lys Glu Asn Ala His Asn Lys Gln Lys Leu Thr Glu Thr Glu Leu Lys 
                485                 490                 495     


Phe Glu Leu Leu Glu Lys Asp Pro Asn Ala Leu Asp Val Ser Asn Thr 
            500                 505                 510         


Ala Phe Gly Arg Glu His Ala Pro Asn Gly Pro Ala Pro Leu Gly Gln 
        515                 520                 525             


Arg Ser Ser Glu Thr Arg Ala Phe Leu Ser Pro Gln Thr Leu Leu Glu 
    530                 535                 540                 


Asp Pro Leu Gly Leu Ser Pro Val Leu Pro Glu Gly Gly Gly Arg Gly 
545                 550                 555                 560 


Pro Arg Gly Pro Gly Asn Pro Leu Asp His Gln Ile Thr Asn Glu Arg 
                565                 570                 575     


Gly Glu Pro Ser Cys Asp Arg Leu Thr Asp Pro His Arg Ala Pro Ser 
            580                 585                 590         


Asp Thr Gly Ser Leu Ser Ser Pro Val Glu Gln Asp Cys Lys Met Met 
        595                 600                 605             


Phe Pro Pro Pro Gly Gln Ser Tyr Pro Asp Ser Ala Leu Pro Pro Gln 
    610                 615                 620                 


Arg Glu Asp Arg Phe Tyr Ser Asn Ser Glu Arg Leu Ser Gly Ser Ala 
625                 630                 635                 640 


Glu Pro Arg Ser Phe Lys Met Thr Ser Leu Asp Lys Met Asp Gly Ser 
                645                 650                 655     


Met Pro Ser Glu Met Glu Ser Ser Arg Asn Asp Ala Lys Asp Asp Leu 
            660                 665                 670         


Gly Asn Leu Asn Val Pro Asp Ser Ser Leu Pro Ala Glu Asn Glu Ala 
        675                 680                 685             


Thr Gly Pro Gly Phe Ile Pro Pro Pro Leu Ala Pro Val Arg Gly Pro 
    690                 695                 700                 


Leu Phe Pro Val Asp Thr Arg Gly Pro Phe Met Arg Arg Gly Pro Pro 
705                 710                 715                 720 


Phe Pro Pro Pro Pro Pro Gly Thr Met Phe Gly Ala Ser Arg Gly Tyr 
                725                 730                 735     


Phe Pro Pro Arg Asp Phe Pro Gly Pro Pro His Ala Pro Phe Ala Met 
            740                 745                 750         


Arg Asn Ile Tyr Pro Pro Arg Gly Leu Pro Pro Tyr Phe His Pro Arg 
        755                 760                 765             


Pro Gly Phe Tyr Pro Asn Pro Ala Phe 
    770                 775         


<210>  2159
<211>  4076
<212>  DNA
<213>  Homosapiens

<400>  2159
tagcaggttg ctactgcccc gaacccgcgc tgcagggaac agcggggcaa acagtgagtg     60

gggttcagcg tagactctgg accaggagag gcccgcggtg accgaggcct gggccccgga    120

aaccaataga gccatggcga ctccctctgc tgccttcgag gcccttatga atggtgtgac    180

aagctgggat gtacccgaag atgctgttcc atgtgaactg cttcttattg gagaggcttc    240

atttcctgtg atggtgaatg acatgggcca ggtcctcatt gctgcctcct cctatggccg    300

tggccgcctg gtggtcgtgt cccatgagga ctacttggtg gaagcccagc tcacgccctt    360

tctcctgaac gcagtggggt ggctttgctc ttcccctggg gctcccattg gtgtacaccc    420

atccctggca cctttggcca aaatcctcga gggctctgga gtggatgcaa aggttgagcc    480

agaagtgaaa gactccctgg gggtttactg tattgatgcc tacaatgaaa ccatgacaga    540

aaagctggtc aagttcatga aatgtggtgg cggcttgctc ataggaggac aagcctggga    600

ttgggccaac cagggggagg atgaaagggt tctgttcacg ttccctggga acctcgtgac    660

cagtgtggct ggcatttact ttactgacaa caaaggggac acgagtttct ttaaagtctc    720

caagaagatg cccaagatcc cagtgttggt tagttgtgaa gatgacctct ccgacgacag    780

agaagagctt ctgcatggga tttcagagct ggacatcagc aactcggatt gtttcccatc    840

ccagctgcta gtgcatgggg ctttagcctt tcctctaggg ttagattcct accatggctg    900

tgttatagcg gctgcccgct atggccgggg ccgggtggtt gtgactggcc ataaggtatt    960

attcactgtt ggtaaactgg gcccctttct gctcaatgct gtccgctggc tggatggggg   1020

ccgcagaggc aagattgtgg tgcagacaga gctgagaacc ctgagtggcc tcctcgcagt   1080

ggggggcata gacaccagca tcgagcccaa tctgaccagt gatgcaagtg tctactgctt   1140

tgaacccgtg agtgaagtgg gggtcaagga actgcaggag tttgtagcag agggtggcgg   1200

gctatttgtt ggagcccaag cctggtggtg ggccttcaag aaccccggag tgtccccttt   1260

ggctcgattc ccaggaaacc tcctcctcaa cccctttggc atcagcatta caagccaaag   1320

cctcaatcca gggccctttc gtactcctaa agcagggata aggacctatc acttccgctc   1380

caccttggcc gagttccagg ttataatggg caggaagaga ggaaatgtgg aaaagggctg   1440

gttggcaaag ctgggaccag atggtgcagc tttcctgcag attcccgcag aagagatccc   1500

tgcctacatg tctgtgcatc gactcctgag gaagctgcta agtcgatatc ggcttccagt   1560

agcaacccga gagaaccctg ttatcaatga ctgctgcaga ggtgctatgc tttccctggc   1620

cacagggctg gcccactctg gaagcgacct ctctctgtta gtcccagaaa ttgaagatat   1680

gtacagcagc ccctatctgc gcccctcaga atctcctatc accgtcgagg tcaactgcac   1740

caatccaggc accagatatt gctggatgag tactgggctc tacatacctg gaaggcaaat   1800

tatagaagtc tcactgcctg aagctgctgc ctctgccgac ctgaagatac agattggctg   1860

ccacacagat gacctgacca gggccagcaa gcttttccga ggcccactcg taattaaccg   1920

gtgctgcttg gacaaaccca caaaatcgat cacgtgcctc tggggtggac tcctctatat   1980

aattgtgcct cagaacagca aactgggttc tgtgcctgtc accgtgaagg gggctgtgca   2040

tgctccatac tacaagctgg gggagaccac cctggaggag tggaagaggc gtatccagga   2100

gaatccaggg ccctggggag agctggccac ggacaacatc attctgaccg tgccgaccgc   2160

aaatcttcgt actctggaga accctgagcc gctgctccgc ctctgggatg aggtgatgca   2220

ggctgtggcg cgactgggag ctgagccctt ccctttgcgc ctgcctcaga ggattgttgc   2280

cgacgtgcag atctcagtgg gctggatgca tgcagggtac cccatcatgt gccatctgga   2340

gtcagtgcag gagctcatca acgagaagct catcagaacc aaggggctgt ggggccccgt   2400

ccatgagctg ggccgcaacc agcagcggca ggagtgggag ttcccaccac acaccaccga   2460

ggccacctgc aacctgtggt gtgtgtatgt gcatgagacg gtcttgggca ttcctcgaag   2520

ccgtgccaat attgctctgt ggcccccagt tcgggagaag agagtcagaa tctacctgag   2580

caagggtccc aatgtgaaaa actggaatgc atggaccgca ctggaaacgt atttacagct   2640

ccaggaagcc tttggttggg agccattcat ccgtctcttc accgagtaca ggaaccagac   2700

caacttgccc acagaaaatg ttgacaaaat gaatctgtgg gtcaagatgt tctcccacca   2760

agtgcagaag aacctggctc cgttctttga ggcctgggcc tggcccatcc agaaggaagt   2820

ggctaccagc ctggcctatc tgcctgaatg gaaggaaaat attatgaaat tgtacctcct   2880

cacacagatg ccccactgaa attgaagtca agaaatgcaa aaaggaactg acacatctca   2940

gcaaagaaaa ctgaagggat ttggttataa gtggagagga tctcagcata tttctggaag   3000

atagaaagtg gatgaagcat gataatgaaa gagtgaagaa cctttcagat aaaatgtaag   3060

ctgatctgaa caacataacc ccaaagagac ttgcgcacct gaaaagcttg tctactgaag   3120

aattactcca gttgtaagat tgagccctct cctactctcc cccaactctt atgcacagaa   3180

cacaggcagt ctccactatt gataccagtt aaaaatttct tgttattgtt gctgttgttg   3240

tttgtataaa ggaattgaac aggctgcttg cagagagata agagttggtg ctccagaaaa   3300

aaatttctct tctagtggaa ataagtgccc ctacccccag ccggtcagct aattctctac   3360

tgacagctga gacctcctac tcaagtgcct gttgccttca ggtatagaag aggtttcctg   3420

aagaaacaga cctaactgta caacagcaga ggaaacccat gccaactgtt atacaagtta   3480

acagttatgt tgattcttaa atgggaatgg tgagttagaa attcccagac atgggcgatg   3540

gggagggaag aggaataaga aaagttacga ggtagaatta ggggccttga aaatatgaca   3600

aactctgagg gaaacaaaga caatgtggaa agaataactt aattttaatt ccatctccag   3660

agagatttga ggtgtattta agatgaaaaa caggatacta caaagaaacg gaaaactcag   3720

gagttcaaga ccagcctagg caagatggca acatcccgtc tctacaaaat aatttttaaa   3780

aattagccaa gcatggtggc atgtgcctgt ggtcctagct acttgggagg ctgaagtggg   3840

aagatcactt gagcccagga gttcaaggct tcagtgagcc atgatggtgc cactgcactc   3900

cagcctgggg gacagagtga gaccctgtct cttaaaaagc aagaaaagaa agagaagact   3960

gagaataaga agatctcttt gaaaataaaa taagactgct aaaagtattt ggtatacagt   4020

ctggaaaata aagttgaggg aatctctcca gataaagagc aaaaagaaat agatag       4076


<210>  2160
<211>  921
<212>  PRT
<213>  Homosapiens

<400>  2160

Met Ala Thr Pro Ser Ala Ala Phe Glu Ala Leu Met Asn Gly Val Thr 
1               5                   10                  15      


Ser Trp Asp Val Pro Glu Asp Ala Val Pro Cys Glu Leu Leu Leu Ile 
            20                  25                  30          


Gly Glu Ala Ser Phe Pro Val Met Val Asn Asp Met Gly Gln Val Leu 
        35                  40                  45              


Ile Ala Ala Ser Ser Tyr Gly Arg Gly Arg Leu Val Val Val Ser His 
    50                  55                  60                  


Glu Asp Tyr Leu Val Glu Ala Gln Leu Thr Pro Phe Leu Leu Asn Ala 
65                  70                  75                  80  


Val Gly Trp Leu Cys Ser Ser Pro Gly Ala Pro Ile Gly Val His Pro 
                85                  90                  95      


Ser Leu Ala Pro Leu Ala Lys Ile Leu Glu Gly Ser Gly Val Asp Ala 
            100                 105                 110         


Lys Val Glu Pro Glu Val Lys Asp Ser Leu Gly Val Tyr Cys Ile Asp 
        115                 120                 125             


Ala Tyr Asn Glu Thr Met Thr Glu Lys Leu Val Lys Phe Met Lys Cys 
    130                 135                 140                 


Gly Gly Gly Leu Leu Ile Gly Gly Gln Ala Trp Asp Trp Ala Asn Gln 
145                 150                 155                 160 


Gly Glu Asp Glu Arg Val Leu Phe Thr Phe Pro Gly Asn Leu Val Thr 
                165                 170                 175     


Ser Val Ala Gly Ile Tyr Phe Thr Asp Asn Lys Gly Asp Thr Ser Phe 
            180                 185                 190         


Phe Lys Val Ser Lys Lys Met Pro Lys Ile Pro Val Leu Val Ser Cys 
        195                 200                 205             


Glu Asp Asp Leu Ser Asp Asp Arg Glu Glu Leu Leu His Gly Ile Ser 
    210                 215                 220                 


Glu Leu Asp Ile Ser Asn Ser Asp Cys Phe Pro Ser Gln Leu Leu Val 
225                 230                 235                 240 


His Gly Ala Leu Ala Phe Pro Leu Gly Leu Asp Ser Tyr His Gly Cys 
                245                 250                 255     


Val Ile Ala Ala Ala Arg Tyr Gly Arg Gly Arg Val Val Val Thr Gly 
            260                 265                 270         


His Lys Val Leu Phe Thr Val Gly Lys Leu Gly Pro Phe Leu Leu Asn 
        275                 280                 285             


Ala Val Arg Trp Leu Asp Gly Gly Arg Arg Gly Lys Ile Val Val Gln 
    290                 295                 300                 


Thr Glu Leu Arg Thr Leu Ser Gly Leu Leu Ala Val Gly Gly Ile Asp 
305                 310                 315                 320 


Thr Ser Ile Glu Pro Asn Leu Thr Ser Asp Ala Ser Val Tyr Cys Phe 
                325                 330                 335     


Glu Pro Val Ser Glu Val Gly Val Lys Glu Leu Gln Glu Phe Val Ala 
            340                 345                 350         


Glu Gly Gly Gly Leu Phe Val Gly Ala Gln Ala Trp Trp Trp Ala Phe 
        355                 360                 365             


Lys Asn Pro Gly Val Ser Pro Leu Ala Arg Phe Pro Gly Asn Leu Leu 
    370                 375                 380                 


Leu Asn Pro Phe Gly Ile Ser Ile Thr Ser Gln Ser Leu Asn Pro Gly 
385                 390                 395                 400 


Pro Phe Arg Thr Pro Lys Ala Gly Ile Arg Thr Tyr His Phe Arg Ser 
                405                 410                 415     


Thr Leu Ala Glu Phe Gln Val Ile Met Gly Arg Lys Arg Gly Asn Val 
            420                 425                 430         


Glu Lys Gly Trp Leu Ala Lys Leu Gly Pro Asp Gly Ala Ala Phe Leu 
        435                 440                 445             


Gln Ile Pro Ala Glu Glu Ile Pro Ala Tyr Met Ser Val His Arg Leu 
    450                 455                 460                 


Leu Arg Lys Leu Leu Ser Arg Tyr Arg Leu Pro Val Ala Thr Arg Glu 
465                 470                 475                 480 


Asn Pro Val Ile Asn Asp Cys Cys Arg Gly Ala Met Leu Ser Leu Ala 
                485                 490                 495     


Thr Gly Leu Ala His Ser Gly Ser Asp Leu Ser Leu Leu Val Pro Glu 
            500                 505                 510         


Ile Glu Asp Met Tyr Ser Ser Pro Tyr Leu Arg Pro Ser Glu Ser Pro 
        515                 520                 525             


Ile Thr Val Glu Val Asn Cys Thr Asn Pro Gly Thr Arg Tyr Cys Trp 
    530                 535                 540                 


Met Ser Thr Gly Leu Tyr Ile Pro Gly Arg Gln Ile Ile Glu Val Ser 
545                 550                 555                 560 


Leu Pro Glu Ala Ala Ala Ser Ala Asp Leu Lys Ile Gln Ile Gly Cys 
                565                 570                 575     


His Thr Asp Asp Leu Thr Arg Ala Ser Lys Leu Phe Arg Gly Pro Leu 
            580                 585                 590         


Val Ile Asn Arg Cys Cys Leu Asp Lys Pro Thr Lys Ser Ile Thr Cys 
        595                 600                 605             


Leu Trp Gly Gly Leu Leu Tyr Ile Ile Val Pro Gln Asn Ser Lys Leu 
    610                 615                 620                 


Gly Ser Val Pro Val Thr Val Lys Gly Ala Val His Ala Pro Tyr Tyr 
625                 630                 635                 640 


Lys Leu Gly Glu Thr Thr Leu Glu Glu Trp Lys Arg Arg Ile Gln Glu 
                645                 650                 655     


Asn Pro Gly Pro Trp Gly Glu Leu Ala Thr Asp Asn Ile Ile Leu Thr 
            660                 665                 670         


Val Pro Thr Ala Asn Leu Arg Thr Leu Glu Asn Pro Glu Pro Leu Leu 
        675                 680                 685             


Arg Leu Trp Asp Glu Val Met Gln Ala Val Ala Arg Leu Gly Ala Glu 
    690                 695                 700                 


Pro Phe Pro Leu Arg Leu Pro Gln Arg Ile Val Ala Asp Val Gln Ile 
705                 710                 715                 720 


Ser Val Gly Trp Met His Ala Gly Tyr Pro Ile Met Cys His Leu Glu 
                725                 730                 735     


Ser Val Gln Glu Leu Ile Asn Glu Lys Leu Ile Arg Thr Lys Gly Leu 
            740                 745                 750         


Trp Gly Pro Val His Glu Leu Gly Arg Asn Gln Gln Arg Gln Glu Trp 
        755                 760                 765             


Glu Phe Pro Pro His Thr Thr Glu Ala Thr Cys Asn Leu Trp Cys Val 
    770                 775                 780                 


Tyr Val His Glu Thr Val Leu Gly Ile Pro Arg Ser Arg Ala Asn Ile 
785                 790                 795                 800 


Ala Leu Trp Pro Pro Val Arg Glu Lys Arg Val Arg Ile Tyr Leu Ser 
                805                 810                 815     


Lys Gly Pro Asn Val Lys Asn Trp Asn Ala Trp Thr Ala Leu Glu Thr 
            820                 825                 830         


Tyr Leu Gln Leu Gln Glu Ala Phe Gly Trp Glu Pro Phe Ile Arg Leu 
        835                 840                 845             


Phe Thr Glu Tyr Arg Asn Gln Thr Asn Leu Pro Thr Glu Asn Val Asp 
    850                 855                 860                 


Lys Met Asn Leu Trp Val Lys Met Phe Ser His Gln Val Gln Lys Asn 
865                 870                 875                 880 


Leu Ala Pro Phe Phe Glu Ala Trp Ala Trp Pro Ile Gln Lys Glu Val 
                885                 890                 895     


Ala Thr Ser Leu Ala Tyr Leu Pro Glu Trp Lys Glu Asn Ile Met Lys 
            900                 905                 910         


Leu Tyr Leu Leu Thr Gln Met Pro His 
        915                 920     


<210>  2161
<211>  954
<212>  DNA
<213>  Homosapiens

<400>  2161
atggaaatag ataaccagac gtgggtgaga gaatttattc tccttggctt atccagtgac     60

tggtgcactc agatatccct gttttccctg ttcttggtca catacctcat gacagtgctg    120

gggaactgtc tcattgtcct tctgatcaga ctggacagcc gactccacac tcccatgtat    180

ttctttctca ccaacctctc ccttgtcgat gtctcctatg ccacaagcgt agtcccccag    240

ctgctggcac attttcttgc agaacataaa gccatcccat tccagagctg tgcagcccag    300

ttatttttct ccctggcctt gggtgggatt gagtttgttc tcctggcagt gatggcctat    360

gaccgccatg tggctgtgtc tgaccgcctg cgatactcgg ccatcatgca tggagggctg    420

tgtgctaggt tggccatcac atcctgggtc agtggctcca tcaactctct tgtgcagact    480

gctatcacct ttcagctgcc catgtgcact aacaagttta ttgatcacat atcctgtgaa    540

ctcctagctg tggtcaggct ggcttgtgtg gacacctcct ccaatgaggc tgccatcatg    600

gtgtctagca ttgttcttct gatgacacct ttctgcctgg ttctgttgtc ctacatccgg    660

atcatctcca ccatcctaaa gatccagtcc agagaaggaa gaaagaaagc cttccacacg    720

tgtgcctctc acctcacggt ggttgccctg tgctacggca caacgatttt cacttacatc    780

cagccccact ctggtccctc agtccttcaa gagaagctga tctctgtctt ctatgccatt    840

gttatgcctc tgctgaaccc tgtgatttat agtctaagga ataaagaggt gaagggggcc    900

tggcataaac tattagagaa attctctggg ttaacatcca agctgggaac ttga          954


<210>  2162
<211>  317
<212>  PRT
<213>  Homosapiens

<400>  2162

Met Glu Ile Asp Asn Gln Thr Trp Val Arg Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Leu Ser Ser Asp Trp Cys Thr Gln Ile Ser Leu Phe Ser Leu Phe Leu 
            20                  25                  30          


Val Thr Tyr Leu Met Thr Val Leu Gly Asn Cys Leu Ile Val Leu Leu 
        35                  40                  45              


Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Thr 
    50                  55                  60                  


Asn Leu Ser Leu Val Asp Val Ser Tyr Ala Thr Ser Val Val Pro Gln 
65                  70                  75                  80  


Leu Leu Ala His Phe Leu Ala Glu His Lys Ala Ile Pro Phe Gln Ser 
                85                  90                  95      


Cys Ala Ala Gln Leu Phe Phe Ser Leu Ala Leu Gly Gly Ile Glu Phe 
            100                 105                 110         


Val Leu Leu Ala Val Met Ala Tyr Asp Arg His Val Ala Val Ser Asp 
        115                 120                 125             


Arg Leu Arg Tyr Ser Ala Ile Met His Gly Gly Leu Cys Ala Arg Leu 
    130                 135                 140                 


Ala Ile Thr Ser Trp Val Ser Gly Ser Ile Asn Ser Leu Val Gln Thr 
145                 150                 155                 160 


Ala Ile Thr Phe Gln Leu Pro Met Cys Thr Asn Lys Phe Ile Asp His 
                165                 170                 175     


Ile Ser Cys Glu Leu Leu Ala Val Val Arg Leu Ala Cys Val Asp Thr 
            180                 185                 190         


Ser Ser Asn Glu Ala Ala Ile Met Val Ser Ser Ile Val Leu Leu Met 
        195                 200                 205             


Thr Pro Phe Cys Leu Val Leu Leu Ser Tyr Ile Arg Ile Ile Ser Thr 
    210                 215                 220                 


Ile Leu Lys Ile Gln Ser Arg Glu Gly Arg Lys Lys Ala Phe His Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Thr Val Val Ala Leu Cys Tyr Gly Thr Thr Ile 
                245                 250                 255     


Phe Thr Tyr Ile Gln Pro His Ser Gly Pro Ser Val Leu Gln Glu Lys 
            260                 265                 270         


Leu Ile Ser Val Phe Tyr Ala Ile Val Met Pro Leu Leu Asn Pro Val 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Trp His Lys Leu 
    290                 295                 300                 


Leu Glu Lys Phe Ser Gly Leu Thr Ser Lys Leu Gly Thr 
305                 310                 315         


<210>  2163
<211>  3154
<212>  DNA
<213>  Homosapiens

<400>  2163
agtttcctcc ccagcagcgc ctgacacagg tgggaatgac agtttgctgc agtcccgtca     60

atgggggaat ctgcccgagc tctgcctgca ttttgagcag caaagcagct ccagccacca    120

agaccgttgc ctgcgctgtc ttaggccagc ccatgctgtc tgccagccgc ttgttgcgct    180

gccttgggga ctgggaacac acccagcccc ggtccccatc tgttgcagac atgcagtggc    240

agcagctcgg agcacagccg aaccctagaa attgcctgtg ctgaaggggc tgggaaaccc    300

cttctctgat ggacctttcg agtgaggcag caggatttgt cagagctggg agtgccgccc    360

gtccccgtca ctcgcatcct gccatccagc agcttacaag cctgcactgc ttattagcat    420

ctggaagaga agacctccag gaccccttgg ggctgagacc tgagctcctt cgccatgccg    480

ctcctggacg gagacctgga gggttccgga aagcattcct ctcgaaaggt ggacagcccc    540

ttcggcccgg gcagcccctc caaagggttc ttctccagag gcccccagcc ccggccctcc    600

agccccatgt ctgcacctgt gaggcccaag accagccccg gctctcccaa aaccgtgttc    660

ccgttctcct accaggagtc cccgccacgc tcccctcgac gcatgagctt cagtgggatc    720

ttccgctcct cctccaaaga gtcttccccc aactccaacc ctgctacctc gcccgggggc    780

atcaggtttt tctcccgctc cagaaaaacc tccggcctct cctcctctcc gtcaacaccc    840

acccaagtga ccaagcagca cacgtttccc ctggaatcct ataagcacga gcctgaacgg    900

ttagagaatc gcatctatgc ctcgtcttcc cccccggaca cagggcagag gttctgcccg    960

tcttccttcc agagcccgac caggcctcca ctggcatcac cgacacacta tgctccctcc   1020

aaagccgcgg cgctggcggc ggccctggga cccgcggaag ccggcatgct ggagaagctg   1080

gagttcgagg acgaagcagt agaagactca gaaagtggtg tttacatgcg attcatgagg   1140

tcacacaagt gttatgacat cgttccaacc agttcaaagc ttgttgtctt tgatactaca   1200

ttacaagtta aaaaggcctt ctttgctttg gtagccaacg gtgtccgagc agcgccactg   1260

tgggagagta aaaaacaaag ttttgtagga atgctaacaa ttacagattt cataaatata   1320

ctacatagat actataaatc acctatggta cagatttatg aattagagga acataaaatt   1380

gaaacatgga gggagcttta tttacaagaa acatttaagc ctttagtgaa tatatctcca   1440

gatgcaagcc tcttcgatgc tgtatactcc ttgatcaaaa ataaaatcca cagattgccc   1500

gttattgacc ctatcagtgg gaatgcactt tatatactta cccacaaaag aatcctcaag   1560

ttcctccagc tttttatgtc tgatatgcca aagcctgcct tcatgaagca gaacctggat   1620

gagcttggaa taggaacgta ccacaacatt gccttcatac atccagacac tcccatcatc   1680

aaagccttga acatatttgt ggaaagacga atatcagctc tgcctgttgt ggatgagtca   1740

ggaaaagttg tagatattta ttccaaattt gatgtaatta atcttgctgc tgagaaaaca   1800

tacaataacc tagatatcac ggtgacccag gcccttcagc accgttcaca gtattttgaa   1860

ggtgttgtga agtgcaataa gctggaaata ctggagacca tcgtggacag aatagtaaga   1920

gctgaggtcc atcggctggt ggtggtaaat gaagcagata gtattgtggg tattatttcc   1980

ctgtcggaca ttctgcaagc cctgatcctc acaccagcag gtgccaaaca aaaggagaca   2040

gaaacggagt gaccgccgtg aatgtagacg ccctaggagg agaacttgaa caaagtctct   2100

gggtcacgtt ttgcctcatg aacactggct gcaagtggtt aagaatgtat atcagggttt   2160

aacaataggt atttcttcca gtgatgttga aattaagctt aaaaaagaaa gattttatgt   2220

gcttgaagat tcaggcttgc attaaaagac tgttttcaga cctttgtctg aaggatttta   2280

aatgctgtat gtcattaaag tgcactgtgt cctgaagttt tcattatttt tcatttcaaa   2340

gaattcactg gtatggaaca ggtgatgtgg cataaggtga gtgcacggta tgttcagatc   2400

acagtgcctt atgtccgaat acagcaatat gtcaccgccg cagccggggc gcacgcgtgt   2460

gaaacaacac cgagcttgaa tgtggaagtc tttgaacctt ttaccaaatc agtttgtttt   2520

ctttagattt gtcaaaaagt tgtaatttga atataaataa ttactttaaa attgtaatga   2580

cacttttaca cgtaagtgtt ttgttctggg ctaccgtgtc aacgaggctg ctttacaaca   2640

gctttattta tttttacttt catgcaattt ttttacacat cttttggtgg agtaaacttc   2700

accacatcca tgaataaact ctcagttatt ttgaaatggc aaatttctca ttatttaagt   2760

ttggatctgg aaaggacatg acttctgaaa tagccgctgc tgggttttaa aagctgaggt   2820

ctctcaaagt gtggaggaga cgttgccgtc aggcgggagc caagtgccgg gaagatgtct   2880

attttttttc ttgtgtattg aaatgtaaaa tcatgatgtt tgttatgact gctgatgcga   2940

ttgtttttgt aaattttatt gtggcatata cagtattgtc atacagttga agagaaacaa   3000

tgtttcctaa tgtaagtgct ctgaaaatgt tgacactgta tatatatata tgaggatagt   3060

ttgttttttt tttgttttgg gttttttttt ttcagattga aaaattaaaa tagatcctac   3120

tatctaccat tttgttaaaa aaaaaaaaaa aaaa                               3154


<210>  2164
<211>  525
<212>  PRT
<213>  Homosapiens

<400>  2164

Met Pro Leu Leu Asp Gly Asp Leu Glu Gly Ser Gly Lys His Ser Ser 
1               5                   10                  15      


Arg Lys Val Asp Ser Pro Phe Gly Pro Gly Ser Pro Ser Lys Gly Phe 
            20                  25                  30          


Phe Ser Arg Gly Pro Gln Pro Arg Pro Ser Ser Pro Met Ser Ala Pro 
        35                  40                  45              


Val Arg Pro Lys Thr Ser Pro Gly Ser Pro Lys Thr Val Phe Pro Phe 
    50                  55                  60                  


Ser Tyr Gln Glu Ser Pro Pro Arg Ser Pro Arg Arg Met Ser Phe Ser 
65                  70                  75                  80  


Gly Ile Phe Arg Ser Ser Ser Lys Glu Ser Ser Pro Asn Ser Asn Pro 
                85                  90                  95      


Ala Thr Ser Pro Gly Gly Ile Arg Phe Phe Ser Arg Ser Arg Lys Thr 
            100                 105                 110         


Ser Gly Leu Ser Ser Ser Pro Ser Thr Pro Thr Gln Val Thr Lys Gln 
        115                 120                 125             


His Thr Phe Pro Leu Glu Ser Tyr Lys His Glu Pro Glu Arg Leu Glu 
    130                 135                 140                 


Asn Arg Ile Tyr Ala Ser Ser Ser Pro Pro Asp Thr Gly Gln Arg Phe 
145                 150                 155                 160 


Cys Pro Ser Ser Phe Gln Ser Pro Thr Arg Pro Pro Leu Ala Ser Pro 
                165                 170                 175     


Thr His Tyr Ala Pro Ser Lys Ala Ala Ala Leu Ala Ala Ala Leu Gly 
            180                 185                 190         


Pro Ala Glu Ala Gly Met Leu Glu Lys Leu Glu Phe Glu Asp Glu Ala 
        195                 200                 205             


Val Glu Asp Ser Glu Ser Gly Val Tyr Met Arg Phe Met Arg Ser His 
    210                 215                 220                 


Lys Cys Tyr Asp Ile Val Pro Thr Ser Ser Lys Leu Val Val Phe Asp 
225                 230                 235                 240 


Thr Thr Leu Gln Val Lys Lys Ala Phe Phe Ala Leu Val Ala Asn Gly 
                245                 250                 255     


Val Arg Ala Ala Pro Leu Trp Glu Ser Lys Lys Gln Ser Phe Val Gly 
            260                 265                 270         


Met Leu Thr Ile Thr Asp Phe Ile Asn Ile Leu His Arg Tyr Tyr Lys 
        275                 280                 285             


Ser Pro Met Val Gln Ile Tyr Glu Leu Glu Glu His Lys Ile Glu Thr 
    290                 295                 300                 


Trp Arg Glu Leu Tyr Leu Gln Glu Thr Phe Lys Pro Leu Val Asn Ile 
305                 310                 315                 320 


Ser Pro Asp Ala Ser Leu Phe Asp Ala Val Tyr Ser Leu Ile Lys Asn 
                325                 330                 335     


Lys Ile His Arg Leu Pro Val Ile Asp Pro Ile Ser Gly Asn Ala Leu 
            340                 345                 350         


Tyr Ile Leu Thr His Lys Arg Ile Leu Lys Phe Leu Gln Leu Phe Met 
        355                 360                 365             


Ser Asp Met Pro Lys Pro Ala Phe Met Lys Gln Asn Leu Asp Glu Leu 
    370                 375                 380                 


Gly Ile Gly Thr Tyr His Asn Ile Ala Phe Ile His Pro Asp Thr Pro 
385                 390                 395                 400 


Ile Ile Lys Ala Leu Asn Ile Phe Val Glu Arg Arg Ile Ser Ala Leu 
                405                 410                 415     


Pro Val Val Asp Glu Ser Gly Lys Val Val Asp Ile Tyr Ser Lys Phe 
            420                 425                 430         


Asp Val Ile Asn Leu Ala Ala Glu Lys Thr Tyr Asn Asn Leu Asp Ile 
        435                 440                 445             


Thr Val Thr Gln Ala Leu Gln His Arg Ser Gln Tyr Phe Glu Gly Val 
    450                 455                 460                 


Val Lys Cys Asn Lys Leu Glu Ile Leu Glu Thr Ile Val Asp Arg Ile 
465                 470                 475                 480 


Val Arg Ala Glu Val His Arg Leu Val Val Val Asn Glu Ala Asp Ser 
                485                 490                 495     


Ile Val Gly Ile Ile Ser Leu Ser Asp Ile Leu Gln Ala Leu Ile Leu 
            500                 505                 510         


Thr Pro Ala Gly Ala Lys Gln Lys Glu Thr Glu Thr Glu 
        515                 520                 525 


<210>  2165
<211>  3423
<212>  DNA
<213>  Homosapiens

<400>  2165
gcggccgccc gtagcctaat tgcgcagagg gctcgccttg cacctcctct tcccccgccg     60

ccctccctct cgcccagaaa ggaggacgga cccagctgca ggctccgagc tggtttattc    120

tgcggccgag gattacattt atgcacgaac gggcttactg gttccagatt ccccacttgg    180

gcacaggcat aggaggcttg ttttccaaat tgctggtttt aattgcacct gcctttcaga    240

ttacctctgg gaatctgtgg gaggagccga gagggtggaa aatgtttctt agctttgcaa    300

aaggaagaaa actttgtcac ccagcgggag acctcagcca cgagtaaccc ggggagacac    360

cagaaccggg acgggctttg actgatttgc ctacgagggt tccgtaggaa aggacgcttg    420

aattcggcgc ttcggcggcg gcggcggccg cgcgagttcc ctgctcaccc tccctctccg    480

cggaagtccc cacgaggtgg cttcagggtg taacagagcg cgcggctcca gtccgaaggc    540

agcggccggg ggagggaagg aggggaccga acccccgagg agtttcgcag aatcaacttc    600

tggttagagt tatgggaagc gcggttatgg acaccaagaa gaaaaaagat gtttccagcc    660

ccggcgggag cggcggcaag aaaaatgcca gccagaagag gcgttcgctg cgcgtgcaca    720

ttccggacct gagctccttc gccatgccgc tcctggacgg agacctggag ggttccggaa    780

agcattcctc tcgaaaggtg gacagcccct tcggcccggg cagcccctcc aaagggttct    840

tctccagagg cccccagccc cggccctcca gccccatgtc tgcacctgtg aggcccaaga    900

ccagccccgg ctctcccaaa accgtgttcc cgttctccta ccaggagtcc ccgccacgct    960

cccctcgacg catgagcttc agtgggatct tccgctcctc ctccaaagag tcttccccca   1020

actccaaccc tgctacctcg cccgggggca tcaggttttt ctcccgctcc agaaaaacct   1080

ccggcctctc ctcctctccg tcaacaccca cccaagtgac caagcagcac acgtttcccc   1140

tggaatccta taagcacgag cctgaacggt tagagaatcg catctatgcc tcgtcttccc   1200

ccccggacac agggcagagg ttctgcccgt cttccttcca gagcccgacc aggcctccac   1260

tggcatcacc gacacactat gctccctcca aagccgcggc gctggcggcg gccctgggac   1320

ccgcggaagc cggcatgctg gagaagctgg agttcgagga cgaagcagta gaagactcag   1380

aaagtggtgt ttacatgcga ttcatgaggt cacacaagtg ttatgacatc gttccaacca   1440

gttcaaagct tgttgtcttt gatactacat tacaagttaa aaaggccttc tttgctttgg   1500

tagccaacgg tgtccgagca gcgccactgt gggagagtaa aaaacaaagt tttgtaggaa   1560

tgctaacaat tacagatttc ataaatatac tacatagata ctataaatca cctatggtac   1620

agatttatga attagaggaa cataaaattg aaacatggag ggagctttat ttacaagaaa   1680

catttaagcc tttagtgaat atatctccag atgcaagcct cttcgatgct gtatactcct   1740

tgatcaaaaa taaaatccac agattgcccg ttattgaccc tatcagtggg aatgcacttt   1800

atatacttac ccacaaaaga atcctcaagt tcctccagct ttttatgtct gatatgccaa   1860

agcctgcctt catgaagcag aacctggatg agcttggaat aggaacgtac cacaacattg   1920

ccttcataca tccagacact cccatcatca aagccttgaa catatttgtg gaaagacgaa   1980

tatcagctct gcctgttgtg gatgagtcag gaaaagttgt agatatttat tccaaatttg   2040

atgtaattaa tcttgctgct gagaaaacat acaataacct agatatcacg gtgacccagg   2100

cccttcagca ccgttcacag tattttgaag gtgttgtgaa gtgcaataag ctggaaatac   2160

tggagaccat cgtggacaga atagtaagag ctgaggtcca tcggctggtg gtggtaaatg   2220

aagcagatag tattgtgggt attatttccc tgtcggacat tctgcaagcc ctgatcctca   2280

caccagcagg tgccaaacaa aaggagacag aaacggagtg accgccgtga atgtagacgc   2340

cctaggagga gaacttgaac aaagtctctg ggtcacgttt tgcctcatga acactggctg   2400

caagtggtta agaatgtata tcagggttta acaataggta tttcttccag tgatgttgaa   2460

attaagctta aaaaagaaag attttatgtg cttgaagatt caggcttgca ttaaaagact   2520

gttttcagac ctttgtctga aggattttaa atgctgtatg tcattaaagt gcactgtgtc   2580

ctgaagtttt cattattttt catttcaaag aattcactgg tatggaacag gtgatgtggc   2640

ataaggtgag tgcacggtat gttcagatca cagtgcctta tgtccgaata cagcaatatg   2700

tcaccgccgc agccggggcg cacgcgtgtg aaacaacacc gagcttgaat gtggaagtct   2760

ttgaaccttt taccaaatca gtttgttttc tttagatttg tcaaaaagtt gtaatttgaa   2820

tataaataat tactttaaaa ttgtaatgac acttttacac gtaagtgttt tgttctgggc   2880

taccgtgtca acgaggctgc tttacaacag ctttatttat ttttactttc atgcaatttt   2940

tttacacatc ttttggtgga gtaaacttca ccacatccat gaataaactc tcagttattt   3000

tgaaatggca aatttctcat tatttaagtt tggatctgga aaggacatga cttctgaaat   3060

agccgctgct gggttttaaa agctgaggtc tctcaaagtg tggaggagac gttgccgtca   3120

ggcgggagcc aagtgccggg aagatgtcta ttttttttct tgtgtattga aatgtaaaat   3180

catgatgttt gttatgactg ctgatgcgat tgtttttgta aattttattg tggcatatac   3240

agtattgtca tacagttgaa gagaaacaat gtttcctaat gtaagtgctc tgaaaatgtt   3300

gacactgtat atatatatat gaggatagtt tgtttttttt ttgttttggg tttttttttt   3360

tcagattgaa aaattaaaat agatcctact atctaccatt ttgttaaaaa aaaaaaaaaa   3420

aaa                                                                 3423


<210>  2166
<211>  569
<212>  PRT
<213>  Homosapiens

<400>  2166

Met Gly Ser Ala Val Met Asp Thr Lys Lys Lys Lys Asp Val Ser Ser 
1               5                   10                  15      


Pro Gly Gly Ser Gly Gly Lys Lys Asn Ala Ser Gln Lys Arg Arg Ser 
            20                  25                  30          


Leu Arg Val His Ile Pro Asp Leu Ser Ser Phe Ala Met Pro Leu Leu 
        35                  40                  45              


Asp Gly Asp Leu Glu Gly Ser Gly Lys His Ser Ser Arg Lys Val Asp 
    50                  55                  60                  


Ser Pro Phe Gly Pro Gly Ser Pro Ser Lys Gly Phe Phe Ser Arg Gly 
65                  70                  75                  80  


Pro Gln Pro Arg Pro Ser Ser Pro Met Ser Ala Pro Val Arg Pro Lys 
                85                  90                  95      


Thr Ser Pro Gly Ser Pro Lys Thr Val Phe Pro Phe Ser Tyr Gln Glu 
            100                 105                 110         


Ser Pro Pro Arg Ser Pro Arg Arg Met Ser Phe Ser Gly Ile Phe Arg 
        115                 120                 125             


Ser Ser Ser Lys Glu Ser Ser Pro Asn Ser Asn Pro Ala Thr Ser Pro 
    130                 135                 140                 


Gly Gly Ile Arg Phe Phe Ser Arg Ser Arg Lys Thr Ser Gly Leu Ser 
145                 150                 155                 160 


Ser Ser Pro Ser Thr Pro Thr Gln Val Thr Lys Gln His Thr Phe Pro 
                165                 170                 175     


Leu Glu Ser Tyr Lys His Glu Pro Glu Arg Leu Glu Asn Arg Ile Tyr 
            180                 185                 190         


Ala Ser Ser Ser Pro Pro Asp Thr Gly Gln Arg Phe Cys Pro Ser Ser 
        195                 200                 205             


Phe Gln Ser Pro Thr Arg Pro Pro Leu Ala Ser Pro Thr His Tyr Ala 
    210                 215                 220                 


Pro Ser Lys Ala Ala Ala Leu Ala Ala Ala Leu Gly Pro Ala Glu Ala 
225                 230                 235                 240 


Gly Met Leu Glu Lys Leu Glu Phe Glu Asp Glu Ala Val Glu Asp Ser 
                245                 250                 255     


Glu Ser Gly Val Tyr Met Arg Phe Met Arg Ser His Lys Cys Tyr Asp 
            260                 265                 270         


Ile Val Pro Thr Ser Ser Lys Leu Val Val Phe Asp Thr Thr Leu Gln 
        275                 280                 285             


Val Lys Lys Ala Phe Phe Ala Leu Val Ala Asn Gly Val Arg Ala Ala 
    290                 295                 300                 


Pro Leu Trp Glu Ser Lys Lys Gln Ser Phe Val Gly Met Leu Thr Ile 
305                 310                 315                 320 


Thr Asp Phe Ile Asn Ile Leu His Arg Tyr Tyr Lys Ser Pro Met Val 
                325                 330                 335     


Gln Ile Tyr Glu Leu Glu Glu His Lys Ile Glu Thr Trp Arg Glu Leu 
            340                 345                 350         


Tyr Leu Gln Glu Thr Phe Lys Pro Leu Val Asn Ile Ser Pro Asp Ala 
        355                 360                 365             


Ser Leu Phe Asp Ala Val Tyr Ser Leu Ile Lys Asn Lys Ile His Arg 
    370                 375                 380                 


Leu Pro Val Ile Asp Pro Ile Ser Gly Asn Ala Leu Tyr Ile Leu Thr 
385                 390                 395                 400 


His Lys Arg Ile Leu Lys Phe Leu Gln Leu Phe Met Ser Asp Met Pro 
                405                 410                 415     


Lys Pro Ala Phe Met Lys Gln Asn Leu Asp Glu Leu Gly Ile Gly Thr 
            420                 425                 430         


Tyr His Asn Ile Ala Phe Ile His Pro Asp Thr Pro Ile Ile Lys Ala 
        435                 440                 445             


Leu Asn Ile Phe Val Glu Arg Arg Ile Ser Ala Leu Pro Val Val Asp 
    450                 455                 460                 


Glu Ser Gly Lys Val Val Asp Ile Tyr Ser Lys Phe Asp Val Ile Asn 
465                 470                 475                 480 


Leu Ala Ala Glu Lys Thr Tyr Asn Asn Leu Asp Ile Thr Val Thr Gln 
                485                 490                 495     


Ala Leu Gln His Arg Ser Gln Tyr Phe Glu Gly Val Val Lys Cys Asn 
            500                 505                 510         


Lys Leu Glu Ile Leu Glu Thr Ile Val Asp Arg Ile Val Arg Ala Glu 
        515                 520                 525             


Val His Arg Leu Val Val Val Asn Glu Ala Asp Ser Ile Val Gly Ile 
    530                 535                 540                 


Ile Ser Leu Ser Asp Ile Leu Gln Ala Leu Ile Leu Thr Pro Ala Gly 
545                 550                 555                 560 


Ala Lys Gln Lys Glu Thr Glu Thr Glu 
                565                 


<210>  2167
<211>  2248
<212>  DNA
<213>  Homosapiens

<400>  2167
aggcccctcc tcccggcggc gcggcagagc caggccccag cgctcggccg gccgcgagcc     60

cgccggccgg ggacgagcgt cgcagctcat gctgatcgct gtcctcctcc tccccctcag    120

gcggcgctgg cggcggccct gggacccgcg gaagccggca tgctggagaa gctggagttc    180

gaggacgaag cagtagaaga ctcagaaagt ggtgtttaca tgcgattcat gaggtcacac    240

aagtgttatg acatcgttcc aaccagttca aagcttgttg tctttgatac tacattacaa    300

gttaaaaagg ccttctttgc tttggtagcc aacggtgtcc gagcagcgcc actgtgggag    360

agtaaaaaac aaagttttgt aggaatgcta acaattacag atttcataaa tatactacat    420

agatactata aatcacctat ggtacagatt tatgaattag aggaacataa aattgaaaca    480

tggagggagc tttatttaca agaaacattt aagcctttag tgaatatatc tccagatgca    540

agcctcttcg atgctgtata ctccttgatc aaaaataaaa tccacagatt gcccgttatt    600

gaccctatca gtgggaatgc actttatata cttacccaca aaagaatcct caagttcctc    660

cagcttttta tgtctgatat gccaaagcct gccttcatga agcagaacct ggatgagctt    720

ggaataggaa cgtaccacaa cattgccttc atacatccag acactcccat catcaaagcc    780

ttgaacatat ttgtggaaag acgaatatca gctctgcctg ttgtggatga gtcaggaaaa    840

gttgtagata tttattccaa atttgatgta attaatcttg ctgctgagaa aacatacaat    900

aacctagata tcacggtgac ccaggccctt cagcaccgtt cacagtattt tgaaggtgtt    960

gtgaagtgca ataagctgga aatactggag accatcgtgg acagaatagt aagagctgag   1020

gtccatcggc tggtggtggt aaatgaagca gatagtattg tgggtattat ttccctgtcg   1080

gacattctgc aagccctgat cctcacacca gcaggtgcca aacaaaagga gacagaaacg   1140

gagtgaccgc cgtgaatgta gacgccctag gaggagaact tgaacaaagt ctctgggtca   1200

cgttttgcct catgaacact ggctgcaagt ggttaagaat gtatatcagg gtttaacaat   1260

aggtatttct tccagtgatg ttgaaattaa gcttaaaaaa gaaagatttt atgtgcttga   1320

agattcaggc ttgcattaaa agactgtttt cagacctttg tctgaaggat tttaaatgct   1380

gtatgtcatt aaagtgcact gtgtcctgaa gttttcatta tttttcattt caaagaattc   1440

actggtatgg aacaggtgat gtggcataag gtgagtgcac ggtatgttca gatcacagtg   1500

ccttatgtcc gaatacagca atatgtcacc gccgcagccg gggcgcacgc gtgtgaaaca   1560

acaccgagct tgaatgtgga agtctttgaa ccttttacca aatcagtttg ttttctttag   1620

atttgtcaaa aagttgtaat ttgaatataa ataattactt taaaattgta atgacacttt   1680

tacacgtaag tgttttgttc tgggctaccg tgtcaacgag gctgctttac aacagcttta   1740

tttattttta ctttcatgca atttttttac acatcttttg gtggagtaaa cttcaccaca   1800

tccatgaata aactctcagt tattttgaaa tggcaaattt ctcattattt aagtttggat   1860

ctggaaagga catgacttct gaaatagccg ctgctgggtt ttaaaagctg aggtctctca   1920

aagtgtggag gagacgttgc cgtcaggcgg gagccaagtg ccgggaagat gtctattttt   1980

tttcttgtgt attgaaatgt aaaatcatga tgtttgttat gactgctgat gcgattgttt   2040

ttgtaaattt tattgtggca tatacagtat tgtcatacag ttgaagagaa acaatgtttc   2100

ctaatgtaag tgctctgaaa atgttgacac tgtatatata tatatgagga tagtttgttt   2160

tttttttgtt ttgggttttt ttttttcaga ttgaaaaatt aaaatagatc ctactatcta   2220

ccattttgtt aaaaaaaaaa aaaaaaaa                                      2248


<210>  2168
<211>  328
<212>  PRT
<213>  Homosapiens

<400>  2168

Met Leu Glu Lys Leu Glu Phe Glu Asp Glu Ala Val Glu Asp Ser Glu 
1               5                   10                  15      


Ser Gly Val Tyr Met Arg Phe Met Arg Ser His Lys Cys Tyr Asp Ile 
            20                  25                  30          


Val Pro Thr Ser Ser Lys Leu Val Val Phe Asp Thr Thr Leu Gln Val 
        35                  40                  45              


Lys Lys Ala Phe Phe Ala Leu Val Ala Asn Gly Val Arg Ala Ala Pro 
    50                  55                  60                  


Leu Trp Glu Ser Lys Lys Gln Ser Phe Val Gly Met Leu Thr Ile Thr 
65                  70                  75                  80  


Asp Phe Ile Asn Ile Leu His Arg Tyr Tyr Lys Ser Pro Met Val Gln 
                85                  90                  95      


Ile Tyr Glu Leu Glu Glu His Lys Ile Glu Thr Trp Arg Glu Leu Tyr 
            100                 105                 110         


Leu Gln Glu Thr Phe Lys Pro Leu Val Asn Ile Ser Pro Asp Ala Ser 
        115                 120                 125             


Leu Phe Asp Ala Val Tyr Ser Leu Ile Lys Asn Lys Ile His Arg Leu 
    130                 135                 140                 


Pro Val Ile Asp Pro Ile Ser Gly Asn Ala Leu Tyr Ile Leu Thr His 
145                 150                 155                 160 


Lys Arg Ile Leu Lys Phe Leu Gln Leu Phe Met Ser Asp Met Pro Lys 
                165                 170                 175     


Pro Ala Phe Met Lys Gln Asn Leu Asp Glu Leu Gly Ile Gly Thr Tyr 
            180                 185                 190         


His Asn Ile Ala Phe Ile His Pro Asp Thr Pro Ile Ile Lys Ala Leu 
        195                 200                 205             


Asn Ile Phe Val Glu Arg Arg Ile Ser Ala Leu Pro Val Val Asp Glu 
    210                 215                 220                 


Ser Gly Lys Val Val Asp Ile Tyr Ser Lys Phe Asp Val Ile Asn Leu 
225                 230                 235                 240 


Ala Ala Glu Lys Thr Tyr Asn Asn Leu Asp Ile Thr Val Thr Gln Ala 
                245                 250                 255     


Leu Gln His Arg Ser Gln Tyr Phe Glu Gly Val Val Lys Cys Asn Lys 
            260                 265                 270         


Leu Glu Ile Leu Glu Thr Ile Val Asp Arg Ile Val Arg Ala Glu Val 
        275                 280                 285             


His Arg Leu Val Val Val Asn Glu Ala Asp Ser Ile Val Gly Ile Ile 
    290                 295                 300                 


Ser Leu Ser Asp Ile Leu Gln Ala Leu Ile Leu Thr Pro Ala Gly Ala 
305                 310                 315                 320 


Lys Gln Lys Glu Thr Glu Thr Glu 
                325             


<210>  2169
<211>  1861
<212>  DNA
<213>  Homosapiens

<400>  2169
tgagggccga gccccgcgcc ggcttcgctg tagtccgcag cccccggcgg ctttgtgggc     60

gcagcacgct cctcagccgc ccgcccacct gggcctgggc cccggttgtt tccctgcggt    120

ggctgtggtc gttcccgttc cagggtctcg agcgcaccgc cccttcgctg cgctgttagt    180

cgagggcagt tttctggggg atcccccgat ccccccgcgc cgctcaggcg tcttggctcg    240

cggaagcgca ggcgccgact gcctggcgtc gtccgtgact cctggccctt ctctgtggat    300

ccctttgctt ctcgttgcgg gttgtgtttc ctgcttcgtg ggcctggccg tttgcgtttg    360

gatgcaggcc cgggtgagcc ctgcgtggcc cgctggcctt ttcctgctcc ctaggtgact    420

gagccgcgtg tgtgacacat cggagtgaat tgaggcaacg cgttcctttc caggcttgca    480

gcgggcggtg tcgttcacgc tcctgagcag agccttccgg tgctttactc gacgccacaa    540

atagtgcagg gttcctccca ggggctgtcg cgagctagaa ctcttccccg cccctgtgag    600

ctcgggctgt tcttcctcct ccgcgtggct cactccagcc tcggatgttt cctcgctgca    660

cagacctgct cgggaagact cgagaaggcc accccaggac tccagctctc cccggaaggg    720

cttcccctcg gattgcgtct tggcccctgg aaccctccct ctgtatcctc tgctgttcct    780

ctcttggcct ccatttgggt tgtggcctgg atactctggc tcgctgcttc ccttctctta    840

aggatcacag ccctgcactg cctgtcgtcc ggtgcctgga aaccattgta ttttttggtc    900

tgattttgta gttgtttgag aacttaagtc tggtccctca cactccatgc ccagaagcag    960

aaatgagtaa agtttgtttt atcttttctt aatatgacaa ttattgtgtt ggttcaactt   1020

atgttgtact ttaattagaa gaaatttggc cgaaaataca aggaaaatat acaaatgcaa   1080

gtaatttttt ttaaacttcc ctgaaagcag ggtctaaaga aattaccaac caacttagac   1140

tggatctaga agaaaaggaa gggtctttgc agtcttagga ctcttccgtt ccgcgacgta   1200

ggtgttagga taacagccat aaatggttgt aagactttgg gctcagataa gtagacttaa   1260

gttcaaattt tgacttattt tacaagtgtg tgatttttgg caagctcatc ttcctaaacc   1320

atgagctcct tatttgtaaa ggggacatta gccactctcc agcaacagcc ctggtacttc   1380

ttcagtcctg ggatgggacg tatgattagc ctaagcgaac cagaaaatcc aggcccgtga   1440

ccagtgactt gatcagggct ggcgatatat ctaggtaggc caaccaggtg gactcagtat   1500

ttttgtgggt gctactggaa aatttattta attctaactg aatgtagaac cagcaacaga   1560

catgaaatgg cagttgtatt gctgtcttat catgaggtga gggcctgaag ctatggtagc   1620

caccctgtga accttggaag gagggttcta caggaactgg cagagctgag actgggacgc   1680

aacccatgtc ctggtgacgt atttgagtcc tgaggctggc cctcctgtta gtcttttctc   1740

ttactggctt cagccagatg gggtctggtt ttctgttact tgcaacagga aaaattggaa   1800

tgatatctat gcatgctatt accgccttat ggctgtggtg agattaaaac atgatactgt   1860

g                                                                   1861


<210>  2170
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  2170

Met Phe Pro Arg Cys Thr Asp Leu Leu Gly Lys Thr Arg Glu Gly His 
1               5                   10                  15      


Pro Arg Thr Pro Ala Leu Pro Gly Arg Ala Ser Pro Arg Ile Ala Ser 
            20                  25                  30          


Trp Pro Leu Glu Pro Ser Leu Cys Ile Leu Cys Cys Ser Ser Leu Gly 
        35                  40                  45              


Leu His Leu Gly Cys Gly Leu Asp Thr Leu Ala Arg Cys Phe Pro Ser 
    50                  55                  60                  


Leu Lys Asp His Ser Pro Ala Leu Pro Val Val Arg Cys Leu Glu Thr 
65                  70                  75                  80  


Ile Val Phe Phe Gly Leu Ile Leu 
                85              


<210>  2171
<211>  1757
<212>  DNA
<213>  Homosapiens

<400>  2171
gagcgcggag gcgggcgttg ctacggcaac ggtgggcggc cagggagttg cctgagggaa     60

aaggggcaga cgtccctggg ttccggtgtt cgcggaggag tcgagcagaa gaatagaagg    120

aaggtgatag gatgtgatga tagaatttgt gatagccaag caacaacttt tcctaattcg    180

gcatgttaaa aaataagggt cactcatcta agaaagataa cttggcagtc aatgcagttg    240

ctttacaaga tcacatttta catgatcttc aacttcgaaa tctttcagtt gcagatcatt    300

ctaagacaca agtacaaaag aaagagaaca aatctctaaa aagagataca aaggcaataa    360

tagatactgg acttaaaaaa actacacagt gccccaaact agaagactca gaaaaagaat    420

atgttcttga tcccaaaccg ccgccgttga ctttggcaca gaagttgggc ctcattgggc    480

ctccaccacc tccactgtca tcagatgaat gggagaaggt gaaacagcgc tctctcctgc    540

aaggggactc cgtgcaacca tgccccatct gtaaagaaga attcgagctt cgtcctcagg    600

tgctgctttc atgctcccat gtgttccaca aagcatgtct tcaggctttt gaaaagttca    660

caaataagaa aacctgtcct ctctgtagaa agaaccagta tcaaacccga gtgatacacg    720

atggggcccg cctgttcaga atcaagtgtg tgaccagaat ccaagcctac tggagaggat    780

gtgttgttag aaagtggtac agaaacctga ggaaaacagt acctcccaca gatgccaagt    840

taagaaaaaa attctttgaa aaaaagttca cagaaatcag ccaccgcatc ctgtgctcat    900

acaacaccaa cattgaagag ctctttgcag aaatcgatca gtgcttggcc ataaatcgaa    960

gtgttcttca gcagttggaa gaaaaatgtg gccatgagat cacagaagag gaatgggaga   1020

aaatccaagt gcaggctctg cgccgggaga cccacgagtg ctccatctgc ctggcccctc   1080

tctccgctgc tggcggtcag cgcgtgggtg caggcaggcg ttccagagag atggccctcc   1140

tgtcctgctc acatgtgttc caccatgcgt gtctgctggc actagaggag ttctccgtgg   1200

gagacaggcc tcctttccat gcctgtcctc tctgccgctc ctgctaccag aagaagattc   1260

ttgaatgttg aattcatagt caaggaaagt taggtaattc tgaggaaaaa agtttaccat   1320

cattttggat gaactgcatg agttctgggt taagtactac aatgtaatct gtttcccagg   1380

gaaataagct attggtagtt gtaggaaatc ttagtatatt ttaaaagctg acatcccacc   1440

taattttaat ctttggtctc taaaaagtaa atttcaaatt tatgagttta atcacttcaa   1500

atatgaatag caaaaaatga gagcttgctt acttctaaaa attgaggtta agatatagct   1560

agtgtctgaa cgacactcct taaagtaagt tccaaatgta aaacactcct taagttccaa   1620

atgttttccg ctaatagtct gtcctaaagc ctttgccatt cctaatactc gttttgtaat   1680

aattgctgta tttctgtgta ataaaatata aaaataaaat attcagtggt attcaacatc   1740

aaaaaaaaaa aaaaaaa                                                  1757


<210>  2172
<211>  362
<212>  PRT
<213>  Homosapiens

<400>  2172

Met Leu Lys Asn Lys Gly His Ser Ser Lys Lys Asp Asn Leu Ala Val 
1               5                   10                  15      


Asn Ala Val Ala Leu Gln Asp His Ile Leu His Asp Leu Gln Leu Arg 
            20                  25                  30          


Asn Leu Ser Val Ala Asp His Ser Lys Thr Gln Val Gln Lys Lys Glu 
        35                  40                  45              


Asn Lys Ser Leu Lys Arg Asp Thr Lys Ala Ile Ile Asp Thr Gly Leu 
    50                  55                  60                  


Lys Lys Thr Thr Gln Cys Pro Lys Leu Glu Asp Ser Glu Lys Glu Tyr 
65                  70                  75                  80  


Val Leu Asp Pro Lys Pro Pro Pro Leu Thr Leu Ala Gln Lys Leu Gly 
                85                  90                  95      


Leu Ile Gly Pro Pro Pro Pro Pro Leu Ser Ser Asp Glu Trp Glu Lys 
            100                 105                 110         


Val Lys Gln Arg Ser Leu Leu Gln Gly Asp Ser Val Gln Pro Cys Pro 
        115                 120                 125             


Ile Cys Lys Glu Glu Phe Glu Leu Arg Pro Gln Val Leu Leu Ser Cys 
    130                 135                 140                 


Ser His Val Phe His Lys Ala Cys Leu Gln Ala Phe Glu Lys Phe Thr 
145                 150                 155                 160 


Asn Lys Lys Thr Cys Pro Leu Cys Arg Lys Asn Gln Tyr Gln Thr Arg 
                165                 170                 175     


Val Ile His Asp Gly Ala Arg Leu Phe Arg Ile Lys Cys Val Thr Arg 
            180                 185                 190         


Ile Gln Ala Tyr Trp Arg Gly Cys Val Val Arg Lys Trp Tyr Arg Asn 
        195                 200                 205             


Leu Arg Lys Thr Val Pro Pro Thr Asp Ala Lys Leu Arg Lys Lys Phe 
    210                 215                 220                 


Phe Glu Lys Lys Phe Thr Glu Ile Ser His Arg Ile Leu Cys Ser Tyr 
225                 230                 235                 240 


Asn Thr Asn Ile Glu Glu Leu Phe Ala Glu Ile Asp Gln Cys Leu Ala 
                245                 250                 255     


Ile Asn Arg Ser Val Leu Gln Gln Leu Glu Glu Lys Cys Gly His Glu 
            260                 265                 270         


Ile Thr Glu Glu Glu Trp Glu Lys Ile Gln Val Gln Ala Leu Arg Arg 
        275                 280                 285             


Glu Thr His Glu Cys Ser Ile Cys Leu Ala Pro Leu Ser Ala Ala Gly 
    290                 295                 300                 


Gly Gln Arg Val Gly Ala Gly Arg Arg Ser Arg Glu Met Ala Leu Leu 
305                 310                 315                 320 


Ser Cys Ser His Val Phe His His Ala Cys Leu Leu Ala Leu Glu Glu 
                325                 330                 335     


Phe Ser Val Gly Asp Arg Pro Pro Phe His Ala Cys Pro Leu Cys Arg 
            340                 345                 350         


Ser Cys Tyr Gln Lys Lys Ile Leu Glu Cys 
        355                 360         


<210>  2173
<211>  2781
<212>  DNA
<213>  Homosapiens

<400>  2173
gccggtgtcg tggtcgcggt acctgttcca acacggctcg cgggcccgtg ccggctccgg     60

tccccggcgc ggctgtccga gcccctgcgg cgggcggacg atggtgtggc ggagcacgcg    120

gacgcgggcg gcgcggcggc gggcatgaag gaggatggaa gggcaggacg aggtgtcggc    180

gcgggagcag cacttccaca gccaagtgcg ggagtccacg atatgtttcc ttctttttgc    240

cattctctac gttgtttcct acttcatcat cacaagatac aagagaaaat cagatgaaca    300

agaagatgaa gatgccatcg tcaacaggat ttcgttgttt ttgagcacgt tcactctcgc    360

agtgtcagct ggggctgttt tgcttttacc cttctcaatc atcagcaatg aaatcctgct    420

ttcttttcct cagaactact atattcagtg gctaaatggc tccctgattc atggtttgtg    480

gaatcttgct tccctttttt ccaacctttg tttatttgta ttgatgccct ttgccttttt    540

ctttctggaa tcagaaggct ttgctggcct gaaaaaggga atccgagccc gcattttaga    600

gactttggtc atgcttcttc ttcttgcgtt actcattctt gggatagtgt gggtagcttc    660

agcactcatt gacaacgatg ccgcaagcat ggaatcttta tatgatctct gggagttcta    720

tctaccctat ttatattcct gtatatcatt gatgggatgt ttgttacttc tcttgtgtac    780

accagttggc ctttctcgta tgttcacagt gatgggtcag ttgctagtga agccaacaat    840

tcttgaagac ctggatgaac aaatttatat cattacctta gaggaagaag cactccagag    900

acgactaaat gggctgtctt catcggtgga atacaacata atggagttgg aacaagaact    960

tgaaaatgta aagactctta agacaaaatt agagaggcga aaaaaggctt cagcatggga   1020

aagaaatttg gtgtatcccg ctgttatggt tctccttctt attgagacat ccatctcggt   1080

cctcttggtg gcttgtaata ttctttgcct attggttgat gaaacagcaa tgccaaaagg   1140

aacaaggggg cctggaatag gaaatgcctc tctttctacg tttggttttg tgggagctgc   1200

gcttgaaatc attttgattt tctatcttat ggtgtcctct gttgtcggct tctatagcct   1260

tcgatttttt ggaaacttta ctcccaagaa agatgacaca actatgacaa agatcattgg   1320

aaattgtgtg tccatcttgg ttttgagctc tgctctgcct gtgatgtcga gaacactggg   1380

aatcactaga tttgatctac ttggcgactt tggaaggttt aattggctgg gaaatttcta   1440

tattgtatta tcctacaatt tgctttttgc tattgtgaca acattgtgtc tggtccgaaa   1500

attcacctct gcagttcgag aagaactttt caaggcccta gggcttcata aacttcactt   1560

accaaatact tcaagggatt cagaaacagc caagccttct gtaaatgggc atcagaaagc   1620

actgtgagac gcacagacgg cgtcttctgc caccaagaga cccgagaact ccagattcac   1680

gacattcctg tcccatgtag aagcatttcc attcaaccgt ggcccctctt cagaacctag   1740

acctatcagt gccatttttt tttcataatc tacgaagaac ttggctatgg ctgatctttt   1800

ttaaatttaa ctttctgatg gaccctgtag tttccagtta agtgcagatt ccttacagac   1860

atatagaaca gcgcattctt ctgtagacat ttgctcatgt tggtaaatac aatcacccat   1920

atgaaaaaat tgttttcacc tgatatgaaa atgttagaaa aggcaaactc cgggacttct   1980

aaagatttac ttaaatccca ttatgtactt tattcagaat gtagaagctg acttgaaagg   2040

catccttggt actaagtgaa gcttattcag aaaatgcatt tttcaaatgc aatggcaact   2100

gcttgtagat atcatttttg cagtgtatgt tggagctgta atggttgcaa ttatgtttct   2160

tatttcctta aaagcaaaaa gcgtagtttc tgatttatgt tatagaatga tactgattag   2220

actttgagcc aaggggaaaa tactaaattc ttttaaacct ggagccttag agagccacag   2280

gaatatcttc tgttgtacag tctaataagc tgtggtagga agtatcatgt aatcacagtt   2340

taatgacagt ttatgtatat atataattca gtattccctc tgataacata gttgccagtg   2400

tttaatacac ttgtaacttg gatttttacc ttataggcta tatgtatact cagtttttta   2460

aagcattttt ttcagagatc acttaattcc ccatgcttct gcaatgcata taaaaactat   2520

aaatgccgag tggtagaaac tcctctttct tcatagtcct caggctttgg ttacatttgc   2580

atatgccatt tgaagcctcc agcttttacc agtttaacat ccaaagttca cagcatcagc   2640

attcatggtg taagaacagt tttgcagtat aacacgatct gataatcatt cagttattaa   2700

attgtaaata attattggga tggtttcttg gctttaagtc cactgaataa aaactatgaa   2760

attgcaaaaa aaaaaaaaaa a                                             2781


<210>  2174
<211>  490
<212>  PRT
<213>  Homosapiens

<400>  2174

Met Glu Gly Gln Asp Glu Val Ser Ala Arg Glu Gln His Phe His Ser 
1               5                   10                  15      


Gln Val Arg Glu Ser Thr Ile Cys Phe Leu Leu Phe Ala Ile Leu Tyr 
            20                  25                  30          


Val Val Ser Tyr Phe Ile Ile Thr Arg Tyr Lys Arg Lys Ser Asp Glu 
        35                  40                  45              


Gln Glu Asp Glu Asp Ala Ile Val Asn Arg Ile Ser Leu Phe Leu Ser 
    50                  55                  60                  


Thr Phe Thr Leu Ala Val Ser Ala Gly Ala Val Leu Leu Leu Pro Phe 
65                  70                  75                  80  


Ser Ile Ile Ser Asn Glu Ile Leu Leu Ser Phe Pro Gln Asn Tyr Tyr 
                85                  90                  95      


Ile Gln Trp Leu Asn Gly Ser Leu Ile His Gly Leu Trp Asn Leu Ala 
            100                 105                 110         


Ser Leu Phe Ser Asn Leu Cys Leu Phe Val Leu Met Pro Phe Ala Phe 
        115                 120                 125             


Phe Phe Leu Glu Ser Glu Gly Phe Ala Gly Leu Lys Lys Gly Ile Arg 
    130                 135                 140                 


Ala Arg Ile Leu Glu Thr Leu Val Met Leu Leu Leu Leu Ala Leu Leu 
145                 150                 155                 160 


Ile Leu Gly Ile Val Trp Val Ala Ser Ala Leu Ile Asp Asn Asp Ala 
                165                 170                 175     


Ala Ser Met Glu Ser Leu Tyr Asp Leu Trp Glu Phe Tyr Leu Pro Tyr 
            180                 185                 190         


Leu Tyr Ser Cys Ile Ser Leu Met Gly Cys Leu Leu Leu Leu Leu Cys 
        195                 200                 205             


Thr Pro Val Gly Leu Ser Arg Met Phe Thr Val Met Gly Gln Leu Leu 
    210                 215                 220                 


Val Lys Pro Thr Ile Leu Glu Asp Leu Asp Glu Gln Ile Tyr Ile Ile 
225                 230                 235                 240 


Thr Leu Glu Glu Glu Ala Leu Gln Arg Arg Leu Asn Gly Leu Ser Ser 
                245                 250                 255     


Ser Val Glu Tyr Asn Ile Met Glu Leu Glu Gln Glu Leu Glu Asn Val 
            260                 265                 270         


Lys Thr Leu Lys Thr Lys Leu Glu Arg Arg Lys Lys Ala Ser Ala Trp 
        275                 280                 285             


Glu Arg Asn Leu Val Tyr Pro Ala Val Met Val Leu Leu Leu Ile Glu 
    290                 295                 300                 


Thr Ser Ile Ser Val Leu Leu Val Ala Cys Asn Ile Leu Cys Leu Leu 
305                 310                 315                 320 


Val Asp Glu Thr Ala Met Pro Lys Gly Thr Arg Gly Pro Gly Ile Gly 
                325                 330                 335     


Asn Ala Ser Leu Ser Thr Phe Gly Phe Val Gly Ala Ala Leu Glu Ile 
            340                 345                 350         


Ile Leu Ile Phe Tyr Leu Met Val Ser Ser Val Val Gly Phe Tyr Ser 
        355                 360                 365             


Leu Arg Phe Phe Gly Asn Phe Thr Pro Lys Lys Asp Asp Thr Thr Met 
    370                 375                 380                 


Thr Lys Ile Ile Gly Asn Cys Val Ser Ile Leu Val Leu Ser Ser Ala 
385                 390                 395                 400 


Leu Pro Val Met Ser Arg Thr Leu Gly Ile Thr Arg Phe Asp Leu Leu 
                405                 410                 415     


Gly Asp Phe Gly Arg Phe Asn Trp Leu Gly Asn Phe Tyr Ile Val Leu 
            420                 425                 430         


Ser Tyr Asn Leu Leu Phe Ala Ile Val Thr Thr Leu Cys Leu Val Arg 
        435                 440                 445             


Lys Phe Thr Ser Ala Val Arg Glu Glu Leu Phe Lys Ala Leu Gly Leu 
    450                 455                 460                 


His Lys Leu His Leu Pro Asn Thr Ser Arg Asp Ser Glu Thr Ala Lys 
465                 470                 475                 480 


Pro Ser Val Asn Gly His Gln Lys Ala Leu 
                485                 490 


<210>  2175
<211>  6082
<212>  DNA
<213>  Homosapiens

<400>  2175
cacgcgtttc gaaagatggc ggcgtccagg agcgcgggag aggccggccc gggcggctcc     60

cagggacgcg tggtccgcat gaagcgcaga ggcgggcgcg ggccgcgccg cggtcctgct    120

ggcggtgggg agaaggccct gaagaggctg aagctagcgg tggaggagtt cgtgcacgcg    180

acttcggaag gcgaggctcc cgggggttgc gaggggcgcg gcgccccggt gagctttcgc    240

ccgggaggga gaaaaagccg taaggaactg aggaaggaga agcggcacct gcggaaagca    300

cgccggctgc agaggacggc gggccccgaa cagggtcccg gcctgggagg ccgaagcgga    360

gccgaagaag ccagcggtca ccggcaggac acggaggagc gcgcccgccc agcccctagt    420

cgggacccct cgcctcccag gaagccgcgg ccgtcccggg tcaaggccaa ggccacggcc    480

gccaccgcaa agaccagacc ctccgcagcc gccaccgccg ctgcccggaa acgggcgctt    540

ttagcggcga acgaggagga ggaccgagag atccgaaagc tggagcgttg cctcggtttg    600

aacaagcgca aaaagaagga cggcagcagc tccgtgccgc tgagctttgc acgcgacggt    660

cttgactata ttctgggagc cctggagtct gggaaaaata gcggcttgta cgacagcagt    720

ggtgaggagg aggaagatgc cggacagaca ctccccgaaa gtgacttaga gagtgactcc    780

caggacgaaa gtgaggagga ggaggaggga gacgtagaaa aggaaaagaa ggcgcaggaa    840

gcagaagcgc agagcgagga cgacgacgag gatacagaag aggaacaggg ggaagaaaag    900

gaaaagggag cgcaggagaa aaggaggggg aagagagtcc gttttgcaga agatgaagaa    960

aagagtgaaa attcctcgga ggacggtgac ataacggata agagtctttg tggaagtggt   1020

gaaaagtaca tcccacctca tgtgaggcaa gctgaggaga cagtggactt caagaaaaag   1080

gaagaactag aaaggctgaa gaaacatgta aaaggtctac ttaacaggtt gagtgaaccc   1140

aacatggctt ccatcagtgg gcagctggag gaactgtaca tggcccacag cagaaaggac   1200

atgaatgaca ccctgacctc cgctctcatg ggtgcctgcg tcactgcctc ggccatgccc   1260

agcagactga tgatggagca tgttctctta gtcagcatcc ttcaccacac agttggaatc   1320

gaggtcggtg cccactttct ggaggcagtg gtgaggaagt tcgatgccat ctataaatac   1380

ggaagcgaag ggaaagagtg tgacaacctg ttcaccgtca ttgcccattt atacaacttc   1440

cacgtggtac agtctctcct catcttcgac attttgaaaa aactgattgg aactttcacc   1500

gaaaaagata ttgaactgat cttgttaatg ctgaaaaacg tgggtttttc attgaggaaa   1560

gatgatgctt tatcacttaa ggaattgatc actgaagccc agaccaaagc cagcggggca   1620

ggcagcgagt ttcaggacca gaccaggatt cggtttatgc tagagacgat gttggccctg   1680

aagaacaatg acatgcgcaa aattccaggc tatgaccccg agcccgtgga gaagctgagg   1740

aaactgcaga gagctttggt ccgcaacgcc ggctcaggtt ctgagacgca gcttcgcgtc   1800

tcctgggaca gtgtcttgag tgcggagcag acgggtcgct ggtggattgt ggggtccgcc   1860

tggagtgggg ccccgatgat cgacaacagt caccatacgc acctgcagaa gcagcttgtg   1920

gggacggtca gttcaaagat cctagaactc gcccggaagc agaggatgaa cacagacatc   1980

cggagaaaca tattctgcac aataatgaca agtgaagatt ttttggatgc ttttgaaaag   2040

cttctgaagc ttggacttaa ggatcagcag gagagagaaa tcattcacgt tctcatggat   2100

tgctgccttc aagagaaaac ttacaatccc ttctatgctt tcctggctag caaattctgt   2160

gaatatgaaa ggagatttca gatgactttc cagttcagca tatgggacaa atttcgggac   2220

ttggaaaact tgccagctac gaatttctct aatttggttc atctggtggc ccacttgttg   2280

aagacaaaat cgctttccct ttccatctta aaggtagttg aattcagtga attggacaaa   2340

cccagagtcc gttttttacg aaaagtatta agtatcctat taatggaaac agaagttgaa   2400

gacctcagtt taattttcac aagagtatct gacaacccaa agctgggggt gttacgtgag   2460

ggtttgaagc ttttcatcag ccacttcttg ctaaagaacg cacaggccca cagaagcgcc   2520

gacgaagcca acgtgctgag agagaaagct gaccttgcaa cgaagtgtct gcaaggaaaa   2580

gcttccctga gaatgtagtc agggaaggaa ggagggcagg tggccctttg actgtaaaat   2640

gtccttggta aacccaaagg cttattctgt tgcctgcgtg tgaatgtttg gtagagctat   2700

atcattgtct gttaatgtat tatattttga gatttttttt gatctaaggt tttattgttt   2760

gtatttcaag ccattttcaa ataactatct tgggggtgag aggagaagga gggagggaaa   2820

aggggtcagg cacactggac agggttctct aagcagtgag gctggtgtgt atgattgtct   2880

taaaattttt taatagatat ggccgagcgt gatggctcac ccctgtaatc ccagcacttt   2940

gtgaggccaa ggtgggcgga tcacttgagg ccaggaattt gaaaccagcc tgggcaaaac   3000

cctgtctcta ctaaaaatat aaaaattagc caggcatgat ggcacatgct ggtaatagca   3060

gctactgagg tggctgaggc acaagaattg cttggaccct ggaggtagag gctgcagtga   3120

gccaagattg taccactgta ctccagcctg ggctggacag tgagactttt gacagtgaga   3180

ctgtcaaaaa aaaaaaaaaa attaatagat aaaacaggcc actagagggt gcagttataa   3240

agaaattgat gaggttttta cctttttaaa atattggtta gaagttcaaa aaccatccct   3300

taaaggtgat tgtttttttg agacagagtc ttgctctgtc acccagagtg gagtgcagtg   3360

tcctgtaatc tcagctcact gcaacctcta cctcccgggt tcaagcgatt ctcctgcctc   3420

agcctcttta gctgggacta caggcgcacg ccaccacgcc cggctaattt ttgtatttta   3480

gtagagatgg gtttcaccat gttggcaagg ctggtcttga actcctgacc tcaggtgata   3540

cacccatctc ggcctcccaa agtgctggga ttacaggctt gagccaccac gcccagctta   3600

aatgtgattc ttgatactgt tttaagtatt taggttgcaa ttaactttgg caaagtcagt   3660

cgacataagc cctgtggata tggccttatg tacactgtaa tgcagacagg tgcttttcat   3720

cattcatgta acattctcac acagttgagg atattcatct cctcaccaat tccagattgt   3780

aaatgtacca tcttaaacaa ctctgaggtc accaaacagt agttatttga ctgttaatag   3840

gtgctacttg cttgcaagga tttggagatg taaacatgaa gaaaatatag ttactgcctg   3900

caaagaatta acatccgtct agtgggagaa acaaacacac cccactcact aagtatggaa   3960

aactgattct gggaggaagc agaaatgtcc ctagataaca gcatgtattg cagataccca   4020

aatgtttatt gttttctcag cccttcaatt ttgcttttct ctctcaaatg ctacagactc   4080

aatttaaatc ttacctttga ttgttgaaaa aagtcactaa gatgtgaata cagaatagac   4140

attgagaggt tatatatgtc caaaactcat ctgtccagca gtcaccgtcc tcttcagagt   4200

ggtcacgttg ggcagatggg cacaggtgct ggtgatgcct ctcctgggca aaacgcccca   4260

tttgtggcac tttcagatac tatttattta ctttttaaga gagagacagg ctcactctgt   4320

cacccaggcc agagtgcagt ggcacgatca tagttaccgc agcatcaaat tcctggactg   4380

aagcggtcct tttgcctcag cctcgcggat agctaggacc acaagcagta gagacaagat   4440

ctccgtatgt tatacaggct ggcctcaagt gatcctctta ccttggcctc ccaaacaccg   4500

ggattatagg cgtgagcccc cgtgcctggc ctcaaatttt attttagctc gaccctatgg   4560

cagtttgtgt ttggaaatcg tgatgtgaag tcatcagtat ctgtgcatat ccctaaacta   4620

atggtttaag ctttgaagca tgcgcaagca acatgaacaa ctgaatacag aaagtaactg   4680

aaagcagcac agagactgtg tcgtccctac agacttctaa ccctgcattc agcaacatca   4740

ttcgacccga agccagattc aaaccctatg tcttctagca ggttctgaat ttagaggaca   4800

aataaggtga caggtactaa gagaagagtg aattaagtga aaatcttccc tttgttaagg   4860

agctttttaa caagagtgtc tttgctgggt ggtgattggg atgtaacaga tcagttctac   4920

tggacttgta gcttgatagt gaaataagga gcttgggcta aggtataaat caacacactg   4980

cttccttcct ccagaaggtc ttactgtgaa ggaaaaaatg tcagttgaac taaattgtgc   5040

ttcacgcctc ggtagatttg cattctgatg caagccccca acctcacgga ccaagaggat   5100

ccctggctgc ctgtgaatgg cccacatttg agtggtgcta acttgatgtg agtaggcatt   5160

aattatgggt gcggctacta agatgggaaa aactatcacg acagtggcac cacctgattt   5220

catgatgtac catatgcagt aacccatgtt tgaggtacag aattgaagct gatttttctg   5280

caaaagatga atttctataa acaatcccat ttttatattt tattattaaa acaaaaatac   5340

ctctctttgc tagagagtta tatgtatgac ttaaattatt agctatggtt tgcatttagt   5400

acatggcaga ttgcctgtaa gtctgttcat tttaacaaca tacagggctg ggcacggtgg   5460

ctcacgcctg taatcccagc actttgggag gttgcgggtg gatcacttga ggtcaggagt   5520

tcgagaccag cctggccaac atggcaaaac cccgtctcta tgaaaaatat aaaaattagc   5580

tgggcatggt ggcaggcacc tgtaatccca gctactcggg aggctgaggc aggagaatcg   5640

cttgaacctg ggaggcggat gttgcagtga gcagagatcg tgccattgca ctccagcctg   5700

ggaacaagag tgaaactctc aaaagcagaa acaaaaaccc aacatatatg ggctgttaga   5760

tagtaattgt aatttcgtat aaatagtaaa tgagtacatc ttgattaaaa gctatgaatt   5820

cagaattgct tttaaatata tagggggttt tttgaaattt attacagtgc aattgaaaat   5880

acacttaaaa tactgcagga tgcttagtgc tcagtgttat gtatgaactt gtggacttta   5940

caatgcaggt tgagaactgc taatgtatag aatgactaaa cagctgtctt tcagggtatc   6000

atttttaaag gtataaggaa caaactttaa tgtattgaaa tgcataaata aaatttattt   6060

tttatatttt gtttagaaaa aa                                            6082


<210>  2176
<211>  860
<212>  PRT
<213>  Homosapiens

<400>  2176

Met Ala Ala Ser Arg Ser Ala Gly Glu Ala Gly Pro Gly Gly Ser Gln 
1               5                   10                  15      


Gly Arg Val Val Arg Met Lys Arg Arg Gly Gly Arg Gly Pro Arg Arg 
            20                  25                  30          


Gly Pro Ala Gly Gly Gly Glu Lys Ala Leu Lys Arg Leu Lys Leu Ala 
        35                  40                  45              


Val Glu Glu Phe Val His Ala Thr Ser Glu Gly Glu Ala Pro Gly Gly 
    50                  55                  60                  


Cys Glu Gly Arg Gly Ala Pro Val Ser Phe Arg Pro Gly Gly Arg Lys 
65                  70                  75                  80  


Ser Arg Lys Glu Leu Arg Lys Glu Lys Arg His Leu Arg Lys Ala Arg 
                85                  90                  95      


Arg Leu Gln Arg Thr Ala Gly Pro Glu Gln Gly Pro Gly Leu Gly Gly 
            100                 105                 110         


Arg Ser Gly Ala Glu Glu Ala Ser Gly His Arg Gln Asp Thr Glu Glu 
        115                 120                 125             


Arg Ala Arg Pro Ala Pro Ser Arg Asp Pro Ser Pro Pro Arg Lys Pro 
    130                 135                 140                 


Arg Pro Ser Arg Val Lys Ala Lys Ala Thr Ala Ala Thr Ala Lys Thr 
145                 150                 155                 160 


Arg Pro Ser Ala Ala Ala Thr Ala Ala Ala Arg Lys Arg Ala Leu Leu 
                165                 170                 175     


Ala Ala Asn Glu Glu Glu Asp Arg Glu Ile Arg Lys Leu Glu Arg Cys 
            180                 185                 190         


Leu Gly Leu Asn Lys Arg Lys Lys Lys Asp Gly Ser Ser Ser Val Pro 
        195                 200                 205             


Leu Ser Phe Ala Arg Asp Gly Leu Asp Tyr Ile Leu Gly Ala Leu Glu 
    210                 215                 220                 


Ser Gly Lys Asn Ser Gly Leu Tyr Asp Ser Ser Gly Glu Glu Glu Glu 
225                 230                 235                 240 


Asp Ala Gly Gln Thr Leu Pro Glu Ser Asp Leu Glu Ser Asp Ser Gln 
                245                 250                 255     


Asp Glu Ser Glu Glu Glu Glu Glu Gly Asp Val Glu Lys Glu Lys Lys 
            260                 265                 270         


Ala Gln Glu Ala Glu Ala Gln Ser Glu Asp Asp Asp Glu Asp Thr Glu 
        275                 280                 285             


Glu Glu Gln Gly Glu Glu Lys Glu Lys Gly Ala Gln Glu Lys Arg Arg 
    290                 295                 300                 


Gly Lys Arg Val Arg Phe Ala Glu Asp Glu Glu Lys Ser Glu Asn Ser 
305                 310                 315                 320 


Ser Glu Asp Gly Asp Ile Thr Asp Lys Ser Leu Cys Gly Ser Gly Glu 
                325                 330                 335     


Lys Tyr Ile Pro Pro His Val Arg Gln Ala Glu Glu Thr Val Asp Phe 
            340                 345                 350         


Lys Lys Lys Glu Glu Leu Glu Arg Leu Lys Lys His Val Lys Gly Leu 
        355                 360                 365             


Leu Asn Arg Leu Ser Glu Pro Asn Met Ala Ser Ile Ser Gly Gln Leu 
    370                 375                 380                 


Glu Glu Leu Tyr Met Ala His Ser Arg Lys Asp Met Asn Asp Thr Leu 
385                 390                 395                 400 


Thr Ser Ala Leu Met Gly Ala Cys Val Thr Ala Ser Ala Met Pro Ser 
                405                 410                 415     


Arg Leu Met Met Glu His Val Leu Leu Val Ser Ile Leu His His Thr 
            420                 425                 430         


Val Gly Ile Glu Val Gly Ala His Phe Leu Glu Ala Val Val Arg Lys 
        435                 440                 445             


Phe Asp Ala Ile Tyr Lys Tyr Gly Ser Glu Gly Lys Glu Cys Asp Asn 
    450                 455                 460                 


Leu Phe Thr Val Ile Ala His Leu Tyr Asn Phe His Val Val Gln Ser 
465                 470                 475                 480 


Leu Leu Ile Phe Asp Ile Leu Lys Lys Leu Ile Gly Thr Phe Thr Glu 
                485                 490                 495     


Lys Asp Ile Glu Leu Ile Leu Leu Met Leu Lys Asn Val Gly Phe Ser 
            500                 505                 510         


Leu Arg Lys Asp Asp Ala Leu Ser Leu Lys Glu Leu Ile Thr Glu Ala 
        515                 520                 525             


Gln Thr Lys Ala Ser Gly Ala Gly Ser Glu Phe Gln Asp Gln Thr Arg 
    530                 535                 540                 


Ile Arg Phe Met Leu Glu Thr Met Leu Ala Leu Lys Asn Asn Asp Met 
545                 550                 555                 560 


Arg Lys Ile Pro Gly Tyr Asp Pro Glu Pro Val Glu Lys Leu Arg Lys 
                565                 570                 575     


Leu Gln Arg Ala Leu Val Arg Asn Ala Gly Ser Gly Ser Glu Thr Gln 
            580                 585                 590         


Leu Arg Val Ser Trp Asp Ser Val Leu Ser Ala Glu Gln Thr Gly Arg 
        595                 600                 605             


Trp Trp Ile Val Gly Ser Ala Trp Ser Gly Ala Pro Met Ile Asp Asn 
    610                 615                 620                 


Ser His His Thr His Leu Gln Lys Gln Leu Val Gly Thr Val Ser Ser 
625                 630                 635                 640 


Lys Ile Leu Glu Leu Ala Arg Lys Gln Arg Met Asn Thr Asp Ile Arg 
                645                 650                 655     


Arg Asn Ile Phe Cys Thr Ile Met Thr Ser Glu Asp Phe Leu Asp Ala 
            660                 665                 670         


Phe Glu Lys Leu Leu Lys Leu Gly Leu Lys Asp Gln Gln Glu Arg Glu 
        675                 680                 685             


Ile Ile His Val Leu Met Asp Cys Cys Leu Gln Glu Lys Thr Tyr Asn 
    690                 695                 700                 


Pro Phe Tyr Ala Phe Leu Ala Ser Lys Phe Cys Glu Tyr Glu Arg Arg 
705                 710                 715                 720 


Phe Gln Met Thr Phe Gln Phe Ser Ile Trp Asp Lys Phe Arg Asp Leu 
                725                 730                 735     


Glu Asn Leu Pro Ala Thr Asn Phe Ser Asn Leu Val His Leu Val Ala 
            740                 745                 750         


His Leu Leu Lys Thr Lys Ser Leu Ser Leu Ser Ile Leu Lys Val Val 
        755                 760                 765             


Glu Phe Ser Glu Leu Asp Lys Pro Arg Val Arg Phe Leu Arg Lys Val 
    770                 775                 780                 


Leu Ser Ile Leu Leu Met Glu Thr Glu Val Glu Asp Leu Ser Leu Ile 
785                 790                 795                 800 


Phe Thr Arg Val Ser Asp Asn Pro Lys Leu Gly Val Leu Arg Glu Gly 
                805                 810                 815     


Leu Lys Leu Phe Ile Ser His Phe Leu Leu Lys Asn Ala Gln Ala His 
            820                 825                 830         


Arg Ser Ala Asp Glu Ala Asn Val Leu Arg Glu Lys Ala Asp Leu Ala 
        835                 840                 845             


Thr Lys Cys Leu Gln Gly Lys Ala Ser Leu Arg Met 
    850                 855                 860 


<210>  2177
<211>  2176
<212>  DNA
<213>  Homosapiens

<400>  2177
cagcggcctc cgcgcggtcg cctgagggct gcagcgcaaa gaaccgggct cccgggcccg     60

gacgcgggga agcactcgcg tgggagtttg tgcgagcgcg gcccggggcg gggcccgcac    120

ggaggaggcg ccgggaccat ggtcaccctc ggctgagttt ccggcggcga ctttgattat    180

tggcaaataa ccaccataac aataccgagc ccccgggctt gcaccgcacg cactgactcc    240

gcgagcccgc acacggccgc gtcgcccgcc accgggccct gagcgccagc cccaaacgag    300

ccgatggaaa aatccaaaaa tttccgcatc gacgccctgc tggcggtgga ccccccacga    360

gccgcctctg cgcagagcgc gccgctggcc ttggtcacgt cgctcgccgc cgccgcatct    420

ggcaccggag gtggcggcgg cggcggcggg gcgagcggcg ggactagcgg cagctgcagc    480

cccgcgtcct cggagccgcc ggctgcgccc gccgaccgcc tgcgcgccga gagcccgtcg    540

ccgccgcgcc tgctggccgc gcactgcgcg ctgctgccca agccgggctt cctgggcgcg    600

ggcggcggcg gcggcggcac gggcggcggg cacggggggc cccaccacca cgcgcatccg    660

ggcgcagcgg ccgctgccgc cgccgccgcc gccgccgccg ccgctggggg cctggcgctg    720

gggctgcacc ctgggggcgc gcagggcggc gcgggcctcc cggcgcaggc ggcgctctac    780

ggccacccgg tctacggcta ctccgcggcg gcggcggcgg ctgcgctggc gggccagcac    840

ccggcgctct cctactcgta cccgcaggtg caaggcgcgc accccgcgca ccccgccgac    900

cccatcaagc tgggcgccgg caccttccag ctggaccagt ggctgcgcgc gtccaccgcg    960

ggcatgatcc tgcctaagat gcccgacttc aactcccagg cgcagtcgaa cctcctgggg   1020

aagtgccgcc ggccgcgcac cgccttcacc agccagcagc tgctggagct ggagcaccag   1080

ttcaagctca acaagtacct gtcgcggccc aagcgcttcg aggtggccac ctcgctcatg   1140

ctcaccgaga cccaggtgaa gatttggttc cagaaccggc ggatgaaatg gaaacgcagc   1200

aaaaaggcca aagagcaggc ggcgcaggaa gcggagaaac agaagggcgg cggcgggggc   1260

gcggggaagg gcggcgcgga ggagccggga gccgaggagc tgctggggcc gccagcgccc   1320

ggagacaagg gcagcggacg ccgcctgcgg gacttgaggg acagtgaccc cgaggaggac   1380

gaggacgagg acgacgagga ccatttcccc tacagcaacg gcgccagcgt ccacgccgcc   1440

tcctccgact gctcctcgga ggacgactcg ccgcccccgc ggcccagcca ccagcccgcg   1500

ccccagtagg agccccgcgg cccagcaggt gcggcgcgca cggagcgccc cggccggcgg   1560

cttctcccgg aggccccggc gcccgcaccc acccggcccg gccccgagag caggctcgac   1620

cgccgcccca tggacccctc gcccaggccg gggctggagg gattcggccg cggctccggt   1680

cctgggcgct tcccttttaa gcaagggcgc ctcacctgct cttcaagaaa cagcgagagg   1740

gagacccagg gggctgaaac ttgaactctg gttcttttaa aattaatttt ggttggtgtt   1800

gggggaggcg cgagtgcgtg tgagaagaac cgacccaccc cgcgcaaggg gaagcctcct   1860

gtctcccctt tccccgcgtc cgagaaggcg gaaacccaca gtgttacctg acttatgaaa   1920

cttgaaaccg cctctggagc cgccattctg cagagtattt ggaaaaagaa aaaagggttt   1980

atgcttacgt ctctggggtc ggggggatta tgtcacgagc gttcaaactg ctggaaatct   2040

caaaactgta ctgtctttat ttttgtatat tgtatttata tataaaaaga aacgtctacg   2100

tatgcatgct aaattattat ttagcttctc ccatcgccca cgatggaatg taaaataaat   2160

tggttttgta ctggat                                                   2176


<210>  2178
<211>  401
<212>  PRT
<213>  Homosapiens

<400>  2178

Met Glu Lys Ser Lys Asn Phe Arg Ile Asp Ala Leu Leu Ala Val Asp 
1               5                   10                  15      


Pro Pro Arg Ala Ala Ser Ala Gln Ser Ala Pro Leu Ala Leu Val Thr 
            20                  25                  30          


Ser Leu Ala Ala Ala Ala Ser Gly Thr Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Ala Ser Gly Gly Thr Ser Gly Ser Cys Ser Pro Ala Ser Ser Glu 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ala Asp Arg Leu Arg Ala Glu Ser Pro Ser Pro 
65                  70                  75                  80  


Pro Arg Leu Leu Ala Ala His Cys Ala Leu Leu Pro Lys Pro Gly Phe 
                85                  90                  95      


Leu Gly Ala Gly Gly Gly Gly Gly Gly Thr Gly Gly Gly His Gly Gly 
            100                 105                 110         


Pro His His His Ala His Pro Gly Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ala Gly Gly Leu Ala Leu Gly Leu His Pro Gly 
    130                 135                 140                 


Gly Ala Gln Gly Gly Ala Gly Leu Pro Ala Gln Ala Ala Leu Tyr Gly 
145                 150                 155                 160 


His Pro Val Tyr Gly Tyr Ser Ala Ala Ala Ala Ala Ala Ala Leu Ala 
                165                 170                 175     


Gly Gln His Pro Ala Leu Ser Tyr Ser Tyr Pro Gln Val Gln Gly Ala 
            180                 185                 190         


His Pro Ala His Pro Ala Asp Pro Ile Lys Leu Gly Ala Gly Thr Phe 
        195                 200                 205             


Gln Leu Asp Gln Trp Leu Arg Ala Ser Thr Ala Gly Met Ile Leu Pro 
    210                 215                 220                 


Lys Met Pro Asp Phe Asn Ser Gln Ala Gln Ser Asn Leu Leu Gly Lys 
225                 230                 235                 240 


Cys Arg Arg Pro Arg Thr Ala Phe Thr Ser Gln Gln Leu Leu Glu Leu 
                245                 250                 255     


Glu His Gln Phe Lys Leu Asn Lys Tyr Leu Ser Arg Pro Lys Arg Phe 
            260                 265                 270         


Glu Val Ala Thr Ser Leu Met Leu Thr Glu Thr Gln Val Lys Ile Trp 
        275                 280                 285             


Phe Gln Asn Arg Arg Met Lys Trp Lys Arg Ser Lys Lys Ala Lys Glu 
    290                 295                 300                 


Gln Ala Ala Gln Glu Ala Glu Lys Gln Lys Gly Gly Gly Gly Gly Ala 
305                 310                 315                 320 


Gly Lys Gly Gly Ala Glu Glu Pro Gly Ala Glu Glu Leu Leu Gly Pro 
                325                 330                 335     


Pro Ala Pro Gly Asp Lys Gly Ser Gly Arg Arg Leu Arg Asp Leu Arg 
            340                 345                 350         


Asp Ser Asp Pro Glu Glu Asp Glu Asp Glu Asp Asp Glu Asp His Phe 
        355                 360                 365             


Pro Tyr Ser Asn Gly Ala Ser Val His Ala Ala Ser Ser Asp Cys Ser 
    370                 375                 380                 


Ser Glu Asp Asp Ser Pro Pro Pro Arg Pro Ser His Gln Pro Ala Pro 
385                 390                 395                 400 


Gln 
    


<210>  2179
<211>  5595
<212>  DNA
<213>  Homosapiens

<400>  2179
cgggggacgc gggggacgcg ggggacggcg gggaacggcg ggggacggcg gggaacagcg     60

ggggacggcg gggaacagcg ggggacggcg gggaacagca ggggactgcg ggtcgcgtcc    120

tggccgccga ggagctcctt cccttaacag agctgagaga ggcatctgga gctgcagcat    180

ggaccagcga gagcccctgc ctcccgctcc tgcagaaaat gaaatgaaat atgataccaa    240

taataatgaa gaggaagagg gagaacagtt cgattttgac agtggagatg aaatcccaga    300

agcggacaga caggccccat ccgcccctga gacaggaggt gctggagcca gtgaagcccc    360

tgcacccaca ggaggtgagg atggagctgg agcagaaacc accccagtgg cagagcctac    420

taagctggtg ctcccgatga aagtcaaccc atattctgtc atcgacatca cgccattcca    480

ggaggaccag ccgcccaccc ccgtgcccag cgctgaggag gagaatgtgg gtctccatgt    540

gccctgcggg tacttggtgc ctgtaccctg cggctatgcg gtgccctcca acctgcccct    600

cctgctgccc gcctactcca gcccggtcat catctgcgcc acgtccctgg acgaagaaga    660

aacaccagaa gtcacagaag atcgccagcc caattctctg agttccgagg agcctccaac    720

cagtgaagat caagtcggtc gagaggacag cgcacttgcc cgctgggccg cagacccggc    780

caacacagcc tggatggaga atccagagga agcaatttac gatgacgttc caagggaaaa    840

ctcagactct gaaccagatg aaatgattta tgatgatgtt gagaatgggg atgaaggtgg    900

aaacagctcc ttggaatacg gatggagttc gagtgaattt gaaagttacg aagagcagag    960

tgactcggag tgcaagaatg ggattcccag gtccttcctg cgcagcaacc acaaaaagca   1020

actttctcat gacctaaccc gtttaaagga gcactatgag aaaaagatga gagatttgat   1080

ggcaagcacg gtgggcgtgg tggagattca gcagctcagg cagaagcatg aactgaagat   1140

gcagaagctc gtgaaggccg cgaaggacgg caccaaggac gggctggaga ggaccagggc   1200

agccgtgaag aggggccgct ccttcatcag gaccaagtct ctcatcgcac aggatcacag   1260

atcttctctt gaggaagaac agaatttgtt cattgatgtt gactgcaagc acccggaagc   1320

catcttgacc ccgatgcccg agggtttatc tcagcagcag gttgtaagaa gatatatact   1380

gggttcagtt gtcgacagtg aaaagaacta cgtagatgct cttaagagga ttttggagca   1440

atatgagaag ccgctgtctg agatggagcc aaaggttctg agtgagagga agctgaagac   1500

ggtgttctac cgagtcaaag agatcctgca gtgccactcg ctatttcaga tcgcgctggc   1560

cagccgcgtt tccgagtggg actccgtgga aatgataggc gatgtcttcg tggcttcgtt   1620

ttctaagtcc atggtgctgg atgcatacag tgaatatgtg aacaatttca gcacagccgt   1680

ggcagtcctc aagaaaacat gtgccacaaa gcccgctttt cttgaatttt taaagcagga   1740

acaggaggcc agccccgatc gaaccacgct ctacagcctg atgatgaagc ccatccagag   1800

gttcccacag ttcatcctcc tgctccagga catgctgaag aacacctcca aaggccaccc   1860

cgacaggctg cctcttcaga tggccctgac agagctcgaa acactagcag agaagttaaa   1920

tgaaagaaag agagatgctg atcaacgctg tgaagtgaag caaatagcca aagccataaa   1980

cgaaagatac ctgaacaagc ttctcagcag tggaagccga tacctcattc gatcagatga   2040

tatgatagaa acagtttaca acgacagagg agagattgtt aaaaccaaag aacgccgagt   2100

cttcatgtta aatgatgtgt taatgtgtgc caccgtcagc tcacgcccct ctcatgacag   2160

ccgtgtgatg agcagccaga ggtacttgct gaagtggagc gttccactgg gacatgtgga   2220

cgccatcgag tatggcagca gcgcaggcac gggcgagcac agcaggcacc ttgccgttca   2280

cccgccggag agcctggccg tggttgctaa cgcgaaacca aacaaagttt acatggggcc   2340

aggacaactg tatcaagatt tacaaaactt gttgcatgac ttaaatgtaa ttggccaaat   2400

cactcagctg ataggaaacc ttaaaggaaa ctatcagaac ttaaaccagt cagtagccca   2460

tgactggaca tcaggtttac aaaggcttat tttgaagaaa gaagatgaaa tcagagctgc   2520

ggactgctgc agaattcagt tacagcttcc cgggaagcag gacaaatctg ggcgaccgac   2580

gttctttaca gctgtgttca atacgttcac ccctgccatc aaggagtcct gggtcaacag   2640

cttacagatg gccaagctcg ccctagaaga ggagaaccac atgggctggt tctgtgtgga   2700

agacgatggg aatcacatta aaaaggagaa gcatcctctc ctcgtcggac acatgcccgt   2760

gatggtggcc aagcagcagg agttcaagat tgaatgtgct gcttataacc ctgaacctta   2820

cctaaataat gaaagccagc cagattcatt ttccacggca catggtttcc tgtggatcgg   2880

aagttgcacc catcaaatgg gtcagattgc catcgtctcg tttcaaaatt ccactcccaa   2940

agtcattgag tgcttcaacg tggaatctcg catcctgtgc atgctgtacg ttcccgtcga   3000

ggagaagcgc agagagcctg gggcaccccc ggaccccgag accccggccg tgagagcttc   3060

tgatgtcccc acgatctgtg tagggacgga ggagggaagc atttccattt ataaaagcag   3120

tcaaggctcc aagaaagtga gacttcagca ctttttcact cctgagaagt ccacagtcat   3180

gagcctggct tgcacgtctc agagcctgta cgctggcctg gtcaacgggg cagtcgccag   3240

ctacgccaga gccccagatg gatcctggga ttcagaacct caaaaagtga tcaagttagg   3300

cgtcctacca gttagaagtc tactcatgat ggaagacacg ttgtgggcgg cttccggagg   3360

tcaagtcttc atcatcagtg tggagactca tgctgtagag ggtcagctgg aggcccacca   3420

ggaggaaggc atggtgatct cccacatggc cgtgtccggc gtcgggatct ggattgcctt   3480

cacctcaggg tccacgctcc gcctttttca cacggaaact ctcaagcacc tgcaggacat   3540

caacatcgcc acccctgttc acaacatgct gccagggcac cagcggctgt cggtgacgag   3600

cctgctcgtc tgccacggat tgctgatggt cggcaccagc ctgggagtcc tcgtggccct   3660

gccggtccca cgtctgcaag ggattcccaa agtgaccgga agaggcatgg tctcctacca   3720

tgcacacaac agtcctgtca aattcatcgt cctggccacg gctctgcacg agaaagacaa   3780

ggacaaatcc agggacagcc tggctcctgg ccccgagcct caggacgaag accagaagga   3840

cgcacttccg agtggaggag ctggttcatc tctgagccag ggtgaccctg acgcagccat   3900

ctggttggga gattcgctgg gatcgatgac tcagaaaagc gacctgtcct cctcatctgg   3960

gtccctgagc ttgtctcacg gctccagctc tctagagcac agatcagagg acagcaccat   4020

ctatgatctc ctgaaggatc ctgtctcgct gagaagcaaa gcacgccggg ccaagaaagc   4080

caaggccagc tcggcgctgg tggtctgtgg agggcagggc caccgccggg tgcacaggaa   4140

ggcccggcag ccccaccagg aagagctggc gccgaccgtc atggtctggc agatccctct   4200

gctgaatata taagcaggac ggccgccttc tgctgtcaga atttgcaatc aagggtgact   4260

tctcagctaa tcctacagcc tgagtggtta agctgtgtct acactggttg ggaataaatt   4320

aaaaacagta tttgggggag aaacgtgcaa tagcgtaatg gtggtgtccc tgccaattcc   4380

ttccttctct tctgtacagc agaagtaatt acaagcactt ctcacgaagg cagaagactg   4440

atgcaatttt cgagtaattg agtgcagttc tgggaaaata ccacattctt tttgactgct   4500

gtagtccata tatgaatact aaatgttaaa cttcatcagc gtcagaccta ttgtatcata   4560

ttagagaatt tgcagactaa gaatttatga gaaaatatat gtattcagta gtgcaggcat   4620

ttattaacaa ttcttaaaag ttttacctga ttcagattca cgacttttat ttatattcta   4680

tatttttgaa tttcagagta aaatttgtta acaattttaa aagccaggta acacctacca   4740

gtccagttag catgatttgc tttcagaagt gagctgggtt ttccaaagtg gtataatgtg   4800

tgtactgtat attttaacaa agtaatattt ttgtattgca tttttctatt aaaaaattaa   4860

cagttaatgt ttcagtcaat gtattatctg tagcatttca caaataatgt ttgctttgaa   4920

ccaaaatgct cagtgcctat caacatttgg actcaagcat caacaccaaa ttattcctcc   4980

cttctcgtat aaatagagtg actatccaca ggagaaaagt gtgtgcttta gtattagagg   5040

agataggcag agaagtcttg cttagttcct tcgtgcagct tcttgcccct gttgacgtgg   5100

aatgctgtgt ctgctttagc acgcacgctc cgaatgactc ctggtgctag gccatgctgg   5160

ctgctgtcac tgagcgggac tcaggccaag aggcgtgacc tcgggccagc ctgtctgttg   5220

tgcagacgcc tcctctgcag aacgcatcag tttctattct gcagttgcag agccagcccc   5280

gcgtgagaac gtgcataatg agtgcacacc atcatgtcaa ggtgcatact tagtgagcgc   5340

catcctgctg aacgtgtatt tcagtgtttc acttactgga cggataacaa gaaaaaaatc   5400

ctaacacagg caggcaccag aaataaatgt ctcagcactt tacagatgac taaaaatgtt   5460

aattttatga cttagccaaa tatgttctag gttgcatata tcccccatgt gaaagtgatt   5520

tcttcccaag cttctcaaac tgttagctgc tgtctgactt catcaataaa gtatttttat   5580

tttaaaatgc aaaaa                                                    5595


<210>  2180
<211>  1344
<212>  PRT
<213>  Homosapiens

<400>  2180

Met Asp Gln Arg Glu Pro Leu Pro Pro Ala Pro Ala Glu Asn Glu Met 
1               5                   10                  15      


Lys Tyr Asp Thr Asn Asn Asn Glu Glu Glu Glu Gly Glu Gln Phe Asp 
            20                  25                  30          


Phe Asp Ser Gly Asp Glu Ile Pro Glu Ala Asp Arg Gln Ala Pro Ser 
        35                  40                  45              


Ala Pro Glu Thr Gly Gly Ala Gly Ala Ser Glu Ala Pro Ala Pro Thr 
    50                  55                  60                  


Gly Gly Glu Asp Gly Ala Gly Ala Glu Thr Thr Pro Val Ala Glu Pro 
65                  70                  75                  80  


Thr Lys Leu Val Leu Pro Met Lys Val Asn Pro Tyr Ser Val Ile Asp 
                85                  90                  95      


Ile Thr Pro Phe Gln Glu Asp Gln Pro Pro Thr Pro Val Pro Ser Ala 
            100                 105                 110         


Glu Glu Glu Asn Val Gly Leu His Val Pro Cys Gly Tyr Leu Val Pro 
        115                 120                 125             


Val Pro Cys Gly Tyr Ala Val Pro Ser Asn Leu Pro Leu Leu Leu Pro 
    130                 135                 140                 


Ala Tyr Ser Ser Pro Val Ile Ile Cys Ala Thr Ser Leu Asp Glu Glu 
145                 150                 155                 160 


Glu Thr Pro Glu Val Thr Glu Asp Arg Gln Pro Asn Ser Leu Ser Ser 
                165                 170                 175     


Glu Glu Pro Pro Thr Ser Glu Asp Gln Val Gly Arg Glu Asp Ser Ala 
            180                 185                 190         


Leu Ala Arg Trp Ala Ala Asp Pro Ala Asn Thr Ala Trp Met Glu Asn 
        195                 200                 205             


Pro Glu Glu Ala Ile Tyr Asp Asp Val Pro Arg Glu Asn Ser Asp Ser 
    210                 215                 220                 


Glu Pro Asp Glu Met Ile Tyr Asp Asp Val Glu Asn Gly Asp Glu Gly 
225                 230                 235                 240 


Gly Asn Ser Ser Leu Glu Tyr Gly Trp Ser Ser Ser Glu Phe Glu Ser 
                245                 250                 255     


Tyr Glu Glu Gln Ser Asp Ser Glu Cys Lys Asn Gly Ile Pro Arg Ser 
            260                 265                 270         


Phe Leu Arg Ser Asn His Lys Lys Gln Leu Ser His Asp Leu Thr Arg 
        275                 280                 285             


Leu Lys Glu His Tyr Glu Lys Lys Met Arg Asp Leu Met Ala Ser Thr 
    290                 295                 300                 


Val Gly Val Val Glu Ile Gln Gln Leu Arg Gln Lys His Glu Leu Lys 
305                 310                 315                 320 


Met Gln Lys Leu Val Lys Ala Ala Lys Asp Gly Thr Lys Asp Gly Leu 
                325                 330                 335     


Glu Arg Thr Arg Ala Ala Val Lys Arg Gly Arg Ser Phe Ile Arg Thr 
            340                 345                 350         


Lys Ser Leu Ile Ala Gln Asp His Arg Ser Ser Leu Glu Glu Glu Gln 
        355                 360                 365             


Asn Leu Phe Ile Asp Val Asp Cys Lys His Pro Glu Ala Ile Leu Thr 
    370                 375                 380                 


Pro Met Pro Glu Gly Leu Ser Gln Gln Gln Val Val Arg Arg Tyr Ile 
385                 390                 395                 400 


Leu Gly Ser Val Val Asp Ser Glu Lys Asn Tyr Val Asp Ala Leu Lys 
                405                 410                 415     


Arg Ile Leu Glu Gln Tyr Glu Lys Pro Leu Ser Glu Met Glu Pro Lys 
            420                 425                 430         


Val Leu Ser Glu Arg Lys Leu Lys Thr Val Phe Tyr Arg Val Lys Glu 
        435                 440                 445             


Ile Leu Gln Cys His Ser Leu Phe Gln Ile Ala Leu Ala Ser Arg Val 
    450                 455                 460                 


Ser Glu Trp Asp Ser Val Glu Met Ile Gly Asp Val Phe Val Ala Ser 
465                 470                 475                 480 


Phe Ser Lys Ser Met Val Leu Asp Ala Tyr Ser Glu Tyr Val Asn Asn 
                485                 490                 495     


Phe Ser Thr Ala Val Ala Val Leu Lys Lys Thr Cys Ala Thr Lys Pro 
            500                 505                 510         


Ala Phe Leu Glu Phe Leu Lys Gln Glu Gln Glu Ala Ser Pro Asp Arg 
        515                 520                 525             


Thr Thr Leu Tyr Ser Leu Met Met Lys Pro Ile Gln Arg Phe Pro Gln 
    530                 535                 540                 


Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn Thr Ser Lys Gly His 
545                 550                 555                 560 


Pro Asp Arg Leu Pro Leu Gln Met Ala Leu Thr Glu Leu Glu Thr Leu 
                565                 570                 575     


Ala Glu Lys Leu Asn Glu Arg Lys Arg Asp Ala Asp Gln Arg Cys Glu 
            580                 585                 590         


Val Lys Gln Ile Ala Lys Ala Ile Asn Glu Arg Tyr Leu Asn Lys Leu 
        595                 600                 605             


Leu Ser Ser Gly Ser Arg Tyr Leu Ile Arg Ser Asp Asp Met Ile Glu 
    610                 615                 620                 


Thr Val Tyr Asn Asp Arg Gly Glu Ile Val Lys Thr Lys Glu Arg Arg 
625                 630                 635                 640 


Val Phe Met Leu Asn Asp Val Leu Met Cys Ala Thr Val Ser Ser Arg 
                645                 650                 655     


Pro Ser His Asp Ser Arg Val Met Ser Ser Gln Arg Tyr Leu Leu Lys 
            660                 665                 670         


Trp Ser Val Pro Leu Gly His Val Asp Ala Ile Glu Tyr Gly Ser Ser 
        675                 680                 685             


Ala Gly Thr Gly Glu His Ser Arg His Leu Ala Val His Pro Pro Glu 
    690                 695                 700                 


Ser Leu Ala Val Val Ala Asn Ala Lys Pro Asn Lys Val Tyr Met Gly 
705                 710                 715                 720 


Pro Gly Gln Leu Tyr Gln Asp Leu Gln Asn Leu Leu His Asp Leu Asn 
                725                 730                 735     


Val Ile Gly Gln Ile Thr Gln Leu Ile Gly Asn Leu Lys Gly Asn Tyr 
            740                 745                 750         


Gln Asn Leu Asn Gln Ser Val Ala His Asp Trp Thr Ser Gly Leu Gln 
        755                 760                 765             


Arg Leu Ile Leu Lys Lys Glu Asp Glu Ile Arg Ala Ala Asp Cys Cys 
    770                 775                 780                 


Arg Ile Gln Leu Gln Leu Pro Gly Lys Gln Asp Lys Ser Gly Arg Pro 
785                 790                 795                 800 


Thr Phe Phe Thr Ala Val Phe Asn Thr Phe Thr Pro Ala Ile Lys Glu 
                805                 810                 815     


Ser Trp Val Asn Ser Leu Gln Met Ala Lys Leu Ala Leu Glu Glu Glu 
            820                 825                 830         


Asn His Met Gly Trp Phe Cys Val Glu Asp Asp Gly Asn His Ile Lys 
        835                 840                 845             


Lys Glu Lys His Pro Leu Leu Val Gly His Met Pro Val Met Val Ala 
    850                 855                 860                 


Lys Gln Gln Glu Phe Lys Ile Glu Cys Ala Ala Tyr Asn Pro Glu Pro 
865                 870                 875                 880 


Tyr Leu Asn Asn Glu Ser Gln Pro Asp Ser Phe Ser Thr Ala His Gly 
                885                 890                 895     


Phe Leu Trp Ile Gly Ser Cys Thr His Gln Met Gly Gln Ile Ala Ile 
            900                 905                 910         


Val Ser Phe Gln Asn Ser Thr Pro Lys Val Ile Glu Cys Phe Asn Val 
        915                 920                 925             


Glu Ser Arg Ile Leu Cys Met Leu Tyr Val Pro Val Glu Glu Lys Arg 
    930                 935                 940                 


Arg Glu Pro Gly Ala Pro Pro Asp Pro Glu Thr Pro Ala Val Arg Ala 
945                 950                 955                 960 


Ser Asp Val Pro Thr Ile Cys Val Gly Thr Glu Glu Gly Ser Ile Ser 
                965                 970                 975     


Ile Tyr Lys Ser Ser Gln Gly Ser Lys Lys Val Arg Leu Gln His Phe 
            980                 985                 990         


Phe Thr Pro Glu Lys Ser Thr Val  Met Ser Leu Ala Cys  Thr Ser Gln 
        995                 1000                 1005             


Ser Leu  Tyr Ala Gly Leu Val  Asn Gly Ala Val Ala  Ser Tyr Ala 
    1010                 1015                 1020             


Arg Ala  Pro Asp Gly Ser Trp  Asp Ser Glu Pro Gln  Lys Val Ile 
    1025                 1030                 1035             


Lys Leu  Gly Val Leu Pro Val  Arg Ser Leu Leu Met  Met Glu Asp 
    1040                 1045                 1050             


Thr Leu  Trp Ala Ala Ser Gly  Gly Gln Val Phe Ile  Ile Ser Val 
    1055                 1060                 1065             


Glu Thr  His Ala Val Glu Gly  Gln Leu Glu Ala His  Gln Glu Glu 
    1070                 1075                 1080             


Gly Met  Val Ile Ser His Met  Ala Val Ser Gly Val  Gly Ile Trp 
    1085                 1090                 1095             


Ile Ala  Phe Thr Ser Gly Ser  Thr Leu Arg Leu Phe  His Thr Glu 
    1100                 1105                 1110             


Thr Leu  Lys His Leu Gln Asp  Ile Asn Ile Ala Thr  Pro Val His 
    1115                 1120                 1125             


Asn Met  Leu Pro Gly His Gln  Arg Leu Ser Val Thr  Ser Leu Leu 
    1130                 1135                 1140             


Val Cys  His Gly Leu Leu Met  Val Gly Thr Ser Leu  Gly Val Leu 
    1145                 1150                 1155             


Val Ala  Leu Pro Val Pro Arg  Leu Gln Gly Ile Pro  Lys Val Thr 
    1160                 1165                 1170             


Gly Arg  Gly Met Val Ser Tyr  His Ala His Asn Ser  Pro Val Lys 
    1175                 1180                 1185             


Phe Ile  Val Leu Ala Thr Ala  Leu His Glu Lys Asp  Lys Asp Lys 
    1190                 1195                 1200             


Ser Arg  Asp Ser Leu Ala Pro  Gly Pro Glu Pro Gln  Asp Glu Asp 
    1205                 1210                 1215             


Gln Lys  Asp Ala Leu Pro Ser  Gly Gly Ala Gly Ser  Ser Leu Ser 
    1220                 1225                 1230             


Gln Gly  Asp Pro Asp Ala Ala  Ile Trp Leu Gly Asp  Ser Leu Gly 
    1235                 1240                 1245             


Ser Met  Thr Gln Lys Ser Asp  Leu Ser Ser Ser Ser  Gly Ser Leu 
    1250                 1255                 1260             


Ser Leu  Ser His Gly Ser Ser  Ser Leu Glu His Arg  Ser Glu Asp 
    1265                 1270                 1275             


Ser Thr  Ile Tyr Asp Leu Leu  Lys Asp Pro Val Ser  Leu Arg Ser 
    1280                 1285                 1290             


Lys Ala  Arg Arg Ala Lys Lys  Ala Lys Ala Ser Ser  Ala Leu Val 
    1295                 1300                 1305             


Val Cys  Gly Gly Gln Gly His  Arg Arg Val His Arg  Lys Ala Arg 
    1310                 1315                 1320             


Gln Pro  His Gln Glu Glu Leu  Ala Pro Thr Val Met  Val Trp Gln 
    1325                 1330                 1335             


Ile Pro  Leu Leu Asn Ile 
    1340                 


<210>  2181
<211>  7389
<212>  DNA
<213>  Homosapiens

<400>  2181
gtcgccttcg tcagacgtca gaatgattcc ttgcagagcc gcgctgacct ttgcccgatg     60

tctgatccgg agaaaaatcg tgaccctgga cagtctagaa gacaccaaat tatgccgctg    120

cttatccacc atggacctca ttgccctggg cgttggaagc acccttgggg ccggggttta    180

tgtcctcgct ggggaggtgg ccaaggcaga ctcgggcccc agcatcgtgg tgtccttcct    240

cattgctgcc ctggcttcag tgatggctgg cctctgctat gccgaatttg gggcccgtgt    300

tcccaagacg gggtctgcat atttgtacac ctacgtgact gtcggagagc tgtgggcctt    360

catcactggc tggaatctca ttttatcgta tgtgataggt acatcaagtg ttgcaagagc    420

ctggagtggc acctttgatg aacttcttag caaacagatt ggtcagtttt tgaggacata    480

cttcagaatg aattacactg gtcttgcaga atatcccgat ttttttgctg tgtgccttat    540

attacttcta gcaggtcttt tgtcttttgg agtaaaagag tctgcttggg tgaataaagt    600

cttcacagct gttaatattc tcgtccttct gtttgtgatg gttgctgggt ttgtgaaagg    660

aaatgtggca aactggaaga ttagtgaaga gtttctcaaa aatatatcag caagtgccag    720

agagccacct tctgaaaacg gaacaagtat ctatggggct ggtggcttta tgccttatgg    780

ctttacggga acgttggctg gtgctgcaac ttgcttttat gcctttgtgg gatttgactg    840

cattgcaaca actggtgaag aagttcggaa tccccagaaa gctattccca ttggaattgt    900

gacgtctttg cttgtttgct ttatggccta ttttggggtc tctgcagctt taacacttat    960

gatgccgtac tacctcctcg atgaaaaaag cccccttcct gtagcgtttg aatatgtggg   1020

atggggtcct gccaaatatg tcgtcgcagc tggttctctc tgcgccttgt caacaagtct   1080

tcttggatcc attttcccaa tgcctcgtgt aatctatgct atggcggagg atgggttgct   1140

tttcaaatgt ctagctcaaa tcaattccaa aacgaagaca ccaataattg ctactttatc   1200

atcgggtgca gtggcagctt tgatggcctt tctgtttgac ctgaaggcgc ttgtggacat   1260

gatgtccatt ggcacactca tggcctactc tctggtggca gcctgtgttc tcatcctcag   1320

gtaccagcct ggcttatctt acgaccagcc caaatgttct cctgagaaag atggtctggg   1380

atcgtctccc agggtaacct cgaagagtga gtcccaggtc accatgctgc agagacaggg   1440

cttcagcatg cggaccctct tctgcccctc ccttctgcca acacagcagt cagcttctct   1500

cgtgagcttt ctggtaggat tcctagcttt cctcgtgttg ggcctgagtg tcttgaccac   1560

ttacggagtt catgccatca ccaggctgga ggcctggagc ctcgctctcc tcgcgctgtt   1620

tcttgttctc ttcgttgcca tcgttctcac catctggagg cagccccaga atcagcaaaa   1680

agtagccttc atggttccat tcttaccatt tttgccagcg ttcagcatct tggtgaacat   1740

ttacttgatg gtccagttaa gtgcagacac ttgggtcaga ttcagcattt ggatggcaat   1800

tggcttcctg atttactttt cttatggcat tagacacagc ctggagggtc atctgagaga   1860

tgaaaacaat gaagaagatg cttatccaga caacgttcat gcagcagcag aagaaaaatc   1920

tgccattcaa gcaaatgacc atcacccaag aaatctcagt tcacctttca tattccatga   1980

aaagacaagt gaattctaac acttgcagga gcagagctgg tcatcgtctt agcatacata   2040

tcctacactg agtaaaccgt aacgggatgt catcagcatg ctgggttgtc atgggtttgc   2100

tgcatacata gttcacccta atttatactt actcatctgg acagcatctc ctcagatggt   2160

gaattatgtg cacggggaaa cctcctgagt ggaagtttca ttcatcagtg atgaatagcc   2220

cccaaacagt gggagtgtgt atgtatgtgt gtatgtatgt atctatgtat atgcttggga   2280

acatgagtgt tacaagttag ctggtgtttt actattattg tgttacattt ttccagtgtc   2340

gtcattaatc ggtggcatat actgcacata ctgaaataga gggaaatcac tgaatgtaaa   2400

gaggtttcat ctatgccccc tgcagttggg gaaatactag tagctttacc ttgtttgact   2460

tcattaatgt cagtttaggg gatgccaaaa atgcagttac tcatcatggt gtctgtcact   2520

ggttaggggt aagatgaggg gataaggaaa gagacttttc aataagttgt gaatgccaac   2580

agtgggttta atgcaaattt tttttcctgt gaggtatgac agtttgctca aacttcagcc   2640

aacaggggtg tctgcttctg ctgcactaca caggccagga gtggcattcc atgccactag   2700

ttggcatcct tttgaacttt tgtctccttt gcaaacagtg gtcctaaaat acgaggtctt   2760

cacttgctgt gaatgacgta tccccagtca gggacttaag agaggcactg tgatatactt   2820

gggacccttt aaattaaaaa gtgaagatag tcaccagggc cagaaagctc atggagtggc   2880

cgtaatgaga atatgtttga agatcaaaga gttagaccaa tgcttgaata agtagacccc   2940

aagcatcctt ttctaaaaag tgacttaaaa taagccaaca gactctccca gaccacacaa   3000

ctagtggaat gattcctcct ttttccatta cttacttaat cacagtttag tttttttctt   3060

aacctcgtca ggcccagagt tcacttcttt gtttctctgt ttcttttgtc ttgtcttaga   3120

gatgaggggg ctacagcagc atcatgcaaa gagggaaaga tgaagggata gaagaagaga   3180

aaatccccct gttctgatag gaacggcctg ttccattgtt aaatggcaaa tggcccaatt   3240

taagggcttt ggatctaatt tgcctctgat gtttcctttg gaaacattta ggaatatttt   3300

tctcccccta ccccataaat tgtgtagcac tttttattcc atttgctttc aaatgactac   3360

actaagccta ataatacaag ctccagtgtt atacaataac ccatcagtga ttggggaatc   3420

aaacattttg gtttaaaaaa catgattatt taaaactgga aactaaaaag aatcaaattg   3480

aattaaagct atataaacac agttaaccct tgtaaatgag taaacaaatt tttacatgta   3540

agattctcta attgtcatat tttacttttt aggattccct aatagtggac tgtttatttg   3600

cagtgtattt gcttctcatg aactatttct cgtacaaatc attaaatagt tcattggatg   3660

aggctgggtg acatttccca ggacagcatg gtgaacatta ccaggcatgc tagctggccc   3720

gtgtaatccc aagacaagga aaacattcgt tttcctcatg ggtcttccaa gaaatgagct   3780

attttattga tgccattaaa aagcaagttg cgatggtttt gtatagccag gagtttattg   3840

tgattaaaca tcaaagaaac aggtagaaag cctgggtttc tggctgctag cgttatagca   3900

tccatgacac agaactcatt acggacattc cacaacttcc agggtgcaca tggtaaaatc   3960

tgaagcccag aattttctct caagctgcgt ggtttactgg agagaaggag ttggataagc   4020

acaggctcgg gtattttggt agggactgta ggcatgctca taaatccttg ctgttgtcac   4080

agtacgctga aaacccgttt gattctatac ccaatcaaga atagaccctt cacacaggaa   4140

atgtgaacaa ttgttatata tgaacactca aatcttttac tgtaacgaaa ccaagaaact   4200

tgtttagaat gtgataggca gctaaaactg ttatgcccac tgtgctcaat ttgaagcaga   4260

attcagtgaa aaattatttt tccacattga aacactttgc agacacaaat atctatgaaa   4320

agatgctttg tcagccactg tgcctttttt tctgtgaaga ctcaacggat gtgtgtgttt   4380

gtatgtttgt taacagttac atatgtttgt atgagtgtat atatatatct gtgtgtgtgt   4440

atctctaacg tcagtgtata agtaagttgg gtttatggtg ggctttgact atgtcattag   4500

gtgggtacaa aacccaactg atgtggagaa aaattgatgt ttgatgttga tagatatgct   4560

tatacctaat ttttagtttt taaactattt taaaatatac tatgatttta tatgtatatt   4620

tcctatagac tctttaagat gtatttataa tgtttctaat atgaaatcac taaactctag   4680

tacattatag caggtgcttt gtaatctgga atggagaaga ggtaggggca tttggggatt   4740

cctgtttact tgctgctgcc acaccttttc cgactgatct gtcctggtag gtgtttatta   4800

gcaaaagtca gtatcaccag ctctttggca cctttctgtt tctgcttgtg aattcataat   4860

gttttcaact aaattttttt tttactttct cagaattacc taaatgtttt gtagagtttt   4920

gactagtaat caatcaaaat tatataaagt cttctccagt aattaagaaa tacatatgca   4980

aattcttttg tgattgagta aaagcagctt aaattacttt tcttttctac attaagaaat   5040

atattctcaa cattttcagt gagaatttct tgtaatggca cctcaaattt tatactctta   5100

aaaaaaaaca ataatttgtg aattaccacc aaaaggcaat ggcagtccta catttaagaa   5160

tagagctatg caaactctgt taaaaactat gaggaaaact tatattagaa cttttgatat   5220

atactaaaat actgattatc ttaatcacat tttccccaga gataaacatt gagagaacga   5280

aagccaaagt gtcatttaag agagatatat atgaaaaagt aacattaata tatagaactt   5340

taccatcacc agccgtagtt gatagaaaat attagtttca gaattaccct cctttaaaaa   5400

ataagagact atttgttttc ttttaatttc tatgaataaa agaaattttt aaaaacttta   5460

aaattttaaa tattagtcaa aatacttttt aagtcctgag tgcttacagg tagttgttaa   5520

aaaaatttta aggccaggca tggtggctcg ctcacaccta taatcctagg atcttgggag   5580

gtcgaggcaa gctgatcgct tgagcccagg agtttaagac cggcctgagt agcatagcaa   5640

gaccctgtct ctacaaaaaa aacaaaaatt agctgggcat ggtggcatgc acatgtagtc   5700

agagctactg ggggtgctga ggtgggagga tcgcttgagc ccaggagagt gaggctgcag   5760

tgagctgaga ttacgccact gcactctagc ctgggcaacg gtgagaccct gcctcaaaaa   5820

aaataaaaat aaaaataaaa cactttaatt agaatctatt tttacctatt ttctaaattt   5880

atttaaatgc ttagcaggaa gcataaggaa aagccatcgg cctccaatac ccatgatgac   5940

agagggagca cttgagcctt gccttccctc ctcttaaatc agggtgtgtt ccgagattac   6000

agaacatcac accttggcgt gatgaaatca tgccaagatt ctgactctcc ctttccggtg   6060

atactgctca tgatttctcc taatacgctt caagcaactg ttaccacaaa aaatacagtt   6120

tccgcagggc tttaaaggat tgagtttagc atgtatatca tgcgttatta aagttcacgt   6180

gattcatgtg aaattaactg tcctttttgc tagtgccaaa acagtgcctt ctctgcacac   6240

tttacttgtt tataaagttc tcccacatgt ccttaaatat caagggggaa agtatggata   6300

ttcgcgtagc aataatgcca gcaaaggtca ttttcatttt ttagtcatat agatatgaaa   6360

ataagttcat atagatatga aattgcttga ctttattgtt ttggggagat tttttttcct   6420

tacatgatta tattaaacac tttaaaatag ccttccggtt tctggatttt gagaagcctg   6480

atctgttatt gttgtggttg ttggtgtttg taatattcat tattgtttgt atatacacgg   6540

tttagtctta ctgatttcaa atgcattttg ttattgctca acccaactgg taacactgtt   6600

tgctgggagc attatactta actttgattc accatggttg atgccactgc catgatcgct   6660

gggtcttaaa gagctttccc tagccactga cagccccgtg gagatcataa tcagggcccc   6720

aggctggttc caggatcagg cagcctatag agtgtgagca tctatgtgta gctacccttg   6780

ttgggtgggc tcttagactg atggggtagg atatgaagtg aaagacttca aatgcaagta   6840

aggtagtttg ggctccttaa ttccaaacat cccatgagta tatcaagatg aataaggacc   6900

aagggacctc tgtgactcat agaagggctg gctgaatcct gaagtagcat agtgggacct   6960

ggtctacaat ttatgcacat gcactgacag ccttgctgtg ccacgtgtct caccaagacc   7020

cagttgggaa agagcgtcat attgccaaca ggttgggttt ctctggccta cacctgatta   7080

atgggccctt tatctttggt gtcccctagg agtgtccagt tgttttattg ctgtattttg   7140

ttattgcagt acttaataaa aattgttgat agggcccaaa accctacaga aattctatgt   7200

ctgtaaaaac caacaaaggc attggacttg tgtgaatgta cagggttttt ttagtagtaa   7260

ttttaaattt aaatgtttta agtgatcatc agtgttcctt tttacttata aagttggatt   7320

cttttttaga atttgtaata aataaaaact gctgctttac cactgtaaaa aaaaaaaaaa   7380

aaaaaaaaa                                                           7389


<210>  2182
<211>  658
<212>  PRT
<213>  Homosapiens

<400>  2182

Met Ile Pro Cys Arg Ala Ala Leu Thr Phe Ala Arg Cys Leu Ile Arg 
1               5                   10                  15      


Arg Lys Ile Val Thr Leu Asp Ser Leu Glu Asp Thr Lys Leu Cys Arg 
            20                  25                  30          


Cys Leu Ser Thr Met Asp Leu Ile Ala Leu Gly Val Gly Ser Thr Leu 
        35                  40                  45              


Gly Ala Gly Val Tyr Val Leu Ala Gly Glu Val Ala Lys Ala Asp Ser 
    50                  55                  60                  


Gly Pro Ser Ile Val Val Ser Phe Leu Ile Ala Ala Leu Ala Ser Val 
65                  70                  75                  80  


Met Ala Gly Leu Cys Tyr Ala Glu Phe Gly Ala Arg Val Pro Lys Thr 
                85                  90                  95      


Gly Ser Ala Tyr Leu Tyr Thr Tyr Val Thr Val Gly Glu Leu Trp Ala 
            100                 105                 110         


Phe Ile Thr Gly Trp Asn Leu Ile Leu Ser Tyr Val Ile Gly Thr Ser 
        115                 120                 125             


Ser Val Ala Arg Ala Trp Ser Gly Thr Phe Asp Glu Leu Leu Ser Lys 
    130                 135                 140                 


Gln Ile Gly Gln Phe Leu Arg Thr Tyr Phe Arg Met Asn Tyr Thr Gly 
145                 150                 155                 160 


Leu Ala Glu Tyr Pro Asp Phe Phe Ala Val Cys Leu Ile Leu Leu Leu 
                165                 170                 175     


Ala Gly Leu Leu Ser Phe Gly Val Lys Glu Ser Ala Trp Val Asn Lys 
            180                 185                 190         


Val Phe Thr Ala Val Asn Ile Leu Val Leu Leu Phe Val Met Val Ala 
        195                 200                 205             


Gly Phe Val Lys Gly Asn Val Ala Asn Trp Lys Ile Ser Glu Glu Phe 
    210                 215                 220                 


Leu Lys Asn Ile Ser Ala Ser Ala Arg Glu Pro Pro Ser Glu Asn Gly 
225                 230                 235                 240 


Thr Ser Ile Tyr Gly Ala Gly Gly Phe Met Pro Tyr Gly Phe Thr Gly 
                245                 250                 255     


Thr Leu Ala Gly Ala Ala Thr Cys Phe Tyr Ala Phe Val Gly Phe Asp 
            260                 265                 270         


Cys Ile Ala Thr Thr Gly Glu Glu Val Arg Asn Pro Gln Lys Ala Ile 
        275                 280                 285             


Pro Ile Gly Ile Val Thr Ser Leu Leu Val Cys Phe Met Ala Tyr Phe 
    290                 295                 300                 


Gly Val Ser Ala Ala Leu Thr Leu Met Met Pro Tyr Tyr Leu Leu Asp 
305                 310                 315                 320 


Glu Lys Ser Pro Leu Pro Val Ala Phe Glu Tyr Val Gly Trp Gly Pro 
                325                 330                 335     


Ala Lys Tyr Val Val Ala Ala Gly Ser Leu Cys Ala Leu Ser Thr Ser 
            340                 345                 350         


Leu Leu Gly Ser Ile Phe Pro Met Pro Arg Val Ile Tyr Ala Met Ala 
        355                 360                 365             


Glu Asp Gly Leu Leu Phe Lys Cys Leu Ala Gln Ile Asn Ser Lys Thr 
    370                 375                 380                 


Lys Thr Pro Ile Ile Ala Thr Leu Ser Ser Gly Ala Val Ala Ala Leu 
385                 390                 395                 400 


Met Ala Phe Leu Phe Asp Leu Lys Ala Leu Val Asp Met Met Ser Ile 
                405                 410                 415     


Gly Thr Leu Met Ala Tyr Ser Leu Val Ala Ala Cys Val Leu Ile Leu 
            420                 425                 430         


Arg Tyr Gln Pro Gly Leu Ser Tyr Asp Gln Pro Lys Cys Ser Pro Glu 
        435                 440                 445             


Lys Asp Gly Leu Gly Ser Ser Pro Arg Val Thr Ser Lys Ser Glu Ser 
    450                 455                 460                 


Gln Val Thr Met Leu Gln Arg Gln Gly Phe Ser Met Arg Thr Leu Phe 
465                 470                 475                 480 


Cys Pro Ser Leu Leu Pro Thr Gln Gln Ser Ala Ser Leu Val Ser Phe 
                485                 490                 495     


Leu Val Gly Phe Leu Ala Phe Leu Val Leu Gly Leu Ser Val Leu Thr 
            500                 505                 510         


Thr Tyr Gly Val His Ala Ile Thr Arg Leu Glu Ala Trp Ser Leu Ala 
        515                 520                 525             


Leu Leu Ala Leu Phe Leu Val Leu Phe Val Ala Ile Val Leu Thr Ile 
    530                 535                 540                 


Trp Arg Gln Pro Gln Asn Gln Gln Lys Val Ala Phe Met Val Pro Phe 
545                 550                 555                 560 


Leu Pro Phe Leu Pro Ala Phe Ser Ile Leu Val Asn Ile Tyr Leu Met 
                565                 570                 575     


Val Gln Leu Ser Ala Asp Thr Trp Val Arg Phe Ser Ile Trp Met Ala 
            580                 585                 590         


Ile Gly Phe Leu Ile Tyr Phe Ser Tyr Gly Ile Arg His Ser Leu Glu 
        595                 600                 605             


Gly His Leu Arg Asp Glu Asn Asn Glu Glu Asp Ala Tyr Pro Asp Asn 
    610                 615                 620                 


Val His Ala Ala Ala Glu Glu Lys Ser Ala Ile Gln Ala Asn Asp His 
625                 630                 635                 640 


His Pro Arg Asn Leu Ser Ser Pro Phe Ile Phe His Glu Lys Thr Ser 
                645                 650                 655     


Glu Phe 
        


<210>  2183
<211>  7514
<212>  DNA
<213>  Homosapiens

<400>  2183
agatgtctca ccacgaaact agcaactgga atgaagatag aaacaagtgg ttataactca     60

gacaaactaa tttgtcgagg gtttattgga acacctgccc caccggtttg cgacagcaag    120

tttctcctgt cgccttcgtc agacgtcaga atgattcctt gcagagccgc gctgaccttt    180

gcccgatgtc tgatccggag aaaaatcgtg accctggaca gtctagaaga caccaaatta    240

tgccgctgct tatccaccat ggacctcatt gccctgggcg ttggaagcac ccttggggcc    300

ggggtttatg tcctcgctgg ggaggtggcc aaggcagact cgggccccag catcgtggtg    360

tccttcctca ttgctgccct ggcttcagtg atggctggcc tctgctatgc cgaatttggg    420

gcccgtgttc ccaagacggg gtctgcatat ttgtacacct acgtgactgt cggagagctg    480

tgggccttca tcactggctg gaatctcatt ttatcgtatg tgataggtac atcaagtgtt    540

gcaagagcct ggagtggcac ctttgatgaa cttcttagca aacagattgg tcagtttttg    600

aggacatact tcagaatgaa ttacactggt cttgcagaat atcccgattt ttttgctgtg    660

tgccttatat tacttctagc aggtcttttg tcttttggag taaaagagtc tgcttgggtg    720

aataaagtct tcacagctgt taatattctc gtccttctgt ttgtgatggt tgctgggttt    780

gtgaaaggaa atgtggcaaa ctggaagatt agtgaagagt ttctcaaaaa tatatcagca    840

agtgccagag agccaccttc tgaaaacgga acaagtatct atggggctgg tggctttatg    900

ccttatggct ttacgggaac gttggctggt gctgcaactt gcttttatgc ctttgtggga    960

tttgactgca ttgcaacaac tggtgaagaa gttcggaatc cccagaaagc tattcccatt   1020

ggaattgtga cgtctttgct tgtttgcttt atggcctatt ttggggtctc tgcagcttta   1080

acacttatga tgccgtacta cctcctcgat gaaaaaagcc cccttcctgt agcgtttgaa   1140

tatgtgggat ggggtcctgc caaatatgtc gtcgcagctg gttctctctg cgccttgtca   1200

acaagtcttc tgggctctat gtttccttta ccccgaattc tgtttgccat ggcccgggat   1260

ggcttactgt ttagatttct tgccagagtg agtaagaggc agtcaccagt tgctgccacg   1320

ttgactgcag gggtcatttc tgctttgatg gcctttctgt ttgacctgaa ggcgcttgtg   1380

gacatgatgt ccattggcac actcatggcc tactctctgg tggcagcctg tgttctcatc   1440

ctcaggtacc agcctggctt atcttacgac cagcccaaat gttctcctga gaaagatggt   1500

ctgggatcgt ctcccagggt aacctcgaag agtgagtccc aggtcaccat gctgcagaga   1560

cagggcttca gcatgcggac cctcttctgc ccctcccttc tgccaacaca gcagtcagct   1620

tctctcgtga gctttctggt aggattccta gctttcctcg tgttgggcct gagtgtcttg   1680

accacttacg gagttcatgc catcaccagg ctggaggcct ggagcctcgc tctcctcgcg   1740

ctgtttcttg ttctcttcgt tgccatcgtt ctcaccatct ggaggctgcc ccagaatcag   1800

caaaaagtag ccttcatggt tccattctta ccatttttgc cagcgttcag catcttggtg   1860

aacatttact tgatggtcca gttaagtgca gacacttggg tcagattcag catttggatg   1920

gcaattggct tcctgattta cttttcttat ggcattagac acagcctgga gggtcatctg   1980

agagatgaaa acaatgaaga agatgcttat ccagacaacg ttcatgcagc agcagaagaa   2040

aaatctgcca ttcaagcaaa tgaccatcac ccaagaaatc tcagttcacc tttcatattc   2100

catgaaaaga caagtgaatt ctaacacttg caggagcaga gctggtcatc gtcttagcat   2160

acatatccta cactgagtaa accgtaacgg gatgtcatca gcatgctggg ttgtcatggg   2220

tttgctgcat acatagttca ccctaattta tacttactca tctggacagc atctcctcag   2280

atggtgaatt atgtgcacgg ggaaacctcc tgagtggaag tttcattcat cagtgatgaa   2340

tagcccccaa acagtgggag tgtgtatgta tgtgtgtatg tatgtatcta tgtatatgct   2400

tgggaacatg agtgttacaa gttagctggt gttttactat tattgtgtta catttttcca   2460

gtgtcgtcat taatcggtgg catatactgc acatactgaa atagagggaa atcactgaat   2520

gtaaagaggt ttcatctatg ccccctgcag ttggggaaat actagtagct ttaccttgtt   2580

tgacttcatt aatgtcagtt taggggatgc caaaaatgca gttactcatc atggtgtctg   2640

tcactggtta ggggtaagat gaggggataa ggaaagagac ttttcaataa gttgtgaatg   2700

ccaacagtgg gtttaatgca aatttttttt cctgtgaggt atgacagttt gctcaaactt   2760

cagccaacag gggtgtctgc ttctgctgca ctacacaggc caggagtggc attccatgcc   2820

actagttggc atccttttga acttttgtct cctttgcaaa cagtggtcct aaaatacgag   2880

gtcttcactt gctgtgaatg acgtatcccc agtcagggac ttaagagagg cactgtgata   2940

tacttgggac cctttaaatt aaaaagtgaa gatagtcacc agggccagaa agctcatgga   3000

gtggccgtaa tgagaatatg tttgaagatc aaagagttag accaatgctt gaataagtag   3060

accccaagca tccttttcta aaaagtgact taaaataagc caacagactc tcccagacca   3120

cacaactagt ggaatgattc ctcctttttc cattacttac ttaatcacag tttagttttt   3180

ttcttaacct cgtcaggccc agagttcact tctttgtttc tctgtttctt ttgtcttgtc   3240

ttagagatga gggggctaca gcagcatcat gcaaagaggg aaagatgaag ggatagaaga   3300

agagaaaatc cccctgttct gataggaacg gcctgttcca ttgttaaatg gcaaatggcc   3360

caatttaagg gctttggatc taatttgcct ctgatgtttc ctttggaaac atttaggaat   3420

atttttctcc ccctacccca taaattgtgt agcacttttt attccatttg ctttcaaatg   3480

actacactaa gcctaataat acaagctcca gtgttataca ataacccatc agtgattggg   3540

gaatcaaaca ttttggttta aaaaacatga ttatttaaaa ctggaaacta aaaagaatca   3600

aattgaatta aagctatata aacacagtta acccttgtaa atgagtaaac aaatttttac   3660

atgtaagatt ctctaattgt catattttac tttttaggat tccctaatag tggactgttt   3720

atttgcagtg tatttgcttc tcatgaacta tttctcgtac aaatcattaa atagttcatt   3780

ggatgaggct gggtgacatt tcccaggaca gcatggtgaa cattaccagg catgctagct   3840

ggcccgtgta atcccaagac aaggaaaaca ttcgttttcc tcatgggtct tccaagaaat   3900

gagctatttt attgatgcca ttaaaaagca agttgcgatg gttttgtata gccaggagtt   3960

tattgtgatt aaacatcaaa gaaacaggta gaaagcctgg gtttctggct gctagcgtta   4020

tagcatccat gacacagaac tcattacgga cattccacaa cttccagggt gcacatggta   4080

aaatctgaag cccagaattt tctctcaagc tgcgtggttt actggagaga aggagttgga   4140

taagcacagg ctcgggtatt ttggtaggga ctgtaggcat gctcataaat ccttgctgtt   4200

gtcacagtac gctgaaaacc cgtttgattc tatacccaat caagaataga cccttcacac   4260

aggaaatgtg aacaattgtt atatatgaac actcaaatct tttactgtaa cgaaaccaag   4320

aaacttgttt agaatgtgat aggcagctaa aactgttatg cccactgtgc tcaatttgaa   4380

gcagaattca gtgaaaaatt atttttccac attgaaacac tttgcagaca caaatatcta   4440

tgaaaagatg ctttgtcagc cactgtgcct ttttttctgt gaagactcaa cggatgtgtg   4500

tgtttgtatg tttgttaaca gttacatatg tttgtatgag tgtatatata tatctgtgtg   4560

tgtgtatctc taacgtcagt gtataagtaa gttgggttta tggtgggctt tgactatgtc   4620

attaggtggg tacaaaaccc aactgatgtg gagaaaaatt gatgtttgat gttgatagat   4680

atgcttatac ctaattttta gtttttaaac tattttaaaa tatactatga ttttatatgt   4740

atatttccta tagactcttt aagatgtatt tataatgttt ctaatatgaa atcactaaac   4800

tctagtacat tatagcaggt gctttgtaat ctggaatgga gaagaggtag gggcatttgg   4860

ggattcctgt ttacttgctg ctgccacacc ttttccgact gatctgtcct ggtaggtgtt   4920

tattagcaaa agtcagtatc accagctctt tggcaccttt ctgtttctgc ttgtgaattc   4980

ataatgtttt caactaaatt ttttttttac tttctcagaa ttacctaaat gttttgtaga   5040

gttttgacta gtaatcaatc aaaattatat aaagtcttct ccagtaatta agaaatacat   5100

atgcaaattc ttttgtgatt gagtaaaagc agcttaaatt acttttcttt tctacattaa   5160

gaaatatatt ctcaacattt tcagtgagaa tttcttgtaa tggcacctca aattttatac   5220

tcttaaaaaa aaacaataat ttgtgaatta ccaccaaaag gcaatggcag tcctacattt   5280

aagaatagag ctatgcaaac tctgttaaaa actatgagga aaacttatat tagaactttt   5340

gatatatact aaaatactga ttatcttaat cacattttcc ccagagataa acattgagag   5400

aacgaaagcc aaagtgtcat ttaagagaga tatatatgaa aaagtaacat taatatatag   5460

aactttacca tcaccagccg tagttgatag aaaatattag tttcagaatt accctccttt   5520

aaaaaataag agactatttg ttttctttta atttctatga ataaaagaaa tttttaaaaa   5580

ctttaaaatt ttaaatatta gtcaaaatac tttttaagtc ctgagtgctt acaggtagtt   5640

gttaaaaaaa ttttaaggcc aggcatggtg gctcgctcac acctataatc ctaggatctt   5700

gggaggtcga ggcaagctga tcgcttgagc ccaggagttt aagaccggcc tgagtagcat   5760

agcaagaccc tgtctctaca aaaaaaacaa aaattagctg ggcatggtgg catgcacatg   5820

tagtcagagc tactgggggt gctgaggtgg gaggatcgct tgagcccagg agagtgaggc   5880

tgcagtgagc tgagattacg ccactgcact ctagcctggg caacggtgag accctgcctc   5940

aaaaaaaata aaaataaaaa taaaacactt taattagaat ctatttttac ctattttcta   6000

aatttattta aatgcttagc aggaagcata aggaaaagcc atcggcctcc aatacccatg   6060

atgacagagg gagcacttga gccttgcctt ccctcctctt aaatcagggt gtgttccgag   6120

attacagaac atcacacctt ggcgtgatga aatcatgcca agattctgac tctccctttc   6180

cggtgatact gctcatgatt tctcctaata cgcttcaagc aactgttacc acaaaaaata   6240

cagtttccgc agggctttaa aggattgagt ttagcatgta tatcatgcgt tattaaagtt   6300

cacgtgattc atgtgaaatt aactgtcctt tttgctagtg ccaaaacagt gccttctctg   6360

cacactttac ttgtttataa agttctccca catgtcctta aatatcaagg gggaaagtat   6420

ggatattcgc gtagcaataa tgccagcaaa ggtcattttc attttttagt catatagata   6480

tgaaaataag ttcatataga tatgaaattg cttgacttta ttgttttggg gagatttttt   6540

ttccttacat gattatatta aacactttaa aatagccttc cggtttctgg attttgagaa   6600

gcctgatctg ttattgttgt ggttgttggt gtttgtaata ttcattattg tttgtatata   6660

cacggtttag tcttactgat ttcaaatgca ttttgttatt gctcaaccca actggtaaca   6720

ctgtttgctg ggagcattat acttaacttt gattcaccat ggttgatgcc actgccatga   6780

tcgctgggtc ttaaagagct ttccctagcc actgacagcc ccgtggagat cataatcagg   6840

gccccaggct ggttccagga tcaggcagcc tatagagtgt gagcatctat gtgtagctac   6900

ccttgttggg tgggctctta gactgatggg gtaggatatg aagtgaaaga cttcaaatgc   6960

aagtaaggta gtttgggctc cttaattcca aacatcccat gagtatatca agatgaataa   7020

ggaccaaggg acctctgtga ctcatagaag ggctggctga atcctgaagt agcatagtgg   7080

gacctggtct acaatttatg cacatgcact gacagccttg ctgtgccacg tgtctcacca   7140

agacccagtt gggaaagagc gtcatattgc caacaggttg ggtttctctg gcctacacct   7200

gattaatggg ccctttatct ttggtgtccc ctaggagtgt ccagttgttt tattgctgta   7260

ttttgttatt gcagtactta ataaaaattg ttgatagggc ccaaaaccct acagaaattc   7320

tatgtctgta aaaaccaaca aaggcattgg acttgtgtga atgtacaggg tttttttagt   7380

agtaatttta aatttaaatg ttttaagtga tcatcagtgt tcctttttac ttataaagtt   7440

ggattctttt ttagaatttg taataaataa aaactgctgc tttaccactg taaaaaaaaa   7500

aaaaaaaaaa aaaa                                                     7514


<210>  2184
<211>  697
<212>  PRT
<213>  Homosapiens

<400>  2184

Met Lys Ile Glu Thr Ser Gly Tyr Asn Ser Asp Lys Leu Ile Cys Arg 
1               5                   10                  15      


Gly Phe Ile Gly Thr Pro Ala Pro Pro Val Cys Asp Ser Lys Phe Leu 
            20                  25                  30          


Leu Ser Pro Ser Ser Asp Val Arg Met Ile Pro Cys Arg Ala Ala Leu 
        35                  40                  45              


Thr Phe Ala Arg Cys Leu Ile Arg Arg Lys Ile Val Thr Leu Asp Ser 
    50                  55                  60                  


Leu Glu Asp Thr Lys Leu Cys Arg Cys Leu Ser Thr Met Asp Leu Ile 
65                  70                  75                  80  


Ala Leu Gly Val Gly Ser Thr Leu Gly Ala Gly Val Tyr Val Leu Ala 
                85                  90                  95      


Gly Glu Val Ala Lys Ala Asp Ser Gly Pro Ser Ile Val Val Ser Phe 
            100                 105                 110         


Leu Ile Ala Ala Leu Ala Ser Val Met Ala Gly Leu Cys Tyr Ala Glu 
        115                 120                 125             


Phe Gly Ala Arg Val Pro Lys Thr Gly Ser Ala Tyr Leu Tyr Thr Tyr 
    130                 135                 140                 


Val Thr Val Gly Glu Leu Trp Ala Phe Ile Thr Gly Trp Asn Leu Ile 
145                 150                 155                 160 


Leu Ser Tyr Val Ile Gly Thr Ser Ser Val Ala Arg Ala Trp Ser Gly 
                165                 170                 175     


Thr Phe Asp Glu Leu Leu Ser Lys Gln Ile Gly Gln Phe Leu Arg Thr 
            180                 185                 190         


Tyr Phe Arg Met Asn Tyr Thr Gly Leu Ala Glu Tyr Pro Asp Phe Phe 
        195                 200                 205             


Ala Val Cys Leu Ile Leu Leu Leu Ala Gly Leu Leu Ser Phe Gly Val 
    210                 215                 220                 


Lys Glu Ser Ala Trp Val Asn Lys Val Phe Thr Ala Val Asn Ile Leu 
225                 230                 235                 240 


Val Leu Leu Phe Val Met Val Ala Gly Phe Val Lys Gly Asn Val Ala 
                245                 250                 255     


Asn Trp Lys Ile Ser Glu Glu Phe Leu Lys Asn Ile Ser Ala Ser Ala 
            260                 265                 270         


Arg Glu Pro Pro Ser Glu Asn Gly Thr Ser Ile Tyr Gly Ala Gly Gly 
        275                 280                 285             


Phe Met Pro Tyr Gly Phe Thr Gly Thr Leu Ala Gly Ala Ala Thr Cys 
    290                 295                 300                 


Phe Tyr Ala Phe Val Gly Phe Asp Cys Ile Ala Thr Thr Gly Glu Glu 
305                 310                 315                 320 


Val Arg Asn Pro Gln Lys Ala Ile Pro Ile Gly Ile Val Thr Ser Leu 
                325                 330                 335     


Leu Val Cys Phe Met Ala Tyr Phe Gly Val Ser Ala Ala Leu Thr Leu 
            340                 345                 350         


Met Met Pro Tyr Tyr Leu Leu Asp Glu Lys Ser Pro Leu Pro Val Ala 
        355                 360                 365             


Phe Glu Tyr Val Gly Trp Gly Pro Ala Lys Tyr Val Val Ala Ala Gly 
    370                 375                 380                 


Ser Leu Cys Ala Leu Ser Thr Ser Leu Leu Gly Ser Met Phe Pro Leu 
385                 390                 395                 400 


Pro Arg Ile Leu Phe Ala Met Ala Arg Asp Gly Leu Leu Phe Arg Phe 
                405                 410                 415     


Leu Ala Arg Val Ser Lys Arg Gln Ser Pro Val Ala Ala Thr Leu Thr 
            420                 425                 430         


Ala Gly Val Ile Ser Ala Leu Met Ala Phe Leu Phe Asp Leu Lys Ala 
        435                 440                 445             


Leu Val Asp Met Met Ser Ile Gly Thr Leu Met Ala Tyr Ser Leu Val 
    450                 455                 460                 


Ala Ala Cys Val Leu Ile Leu Arg Tyr Gln Pro Gly Leu Ser Tyr Asp 
465                 470                 475                 480 


Gln Pro Lys Cys Ser Pro Glu Lys Asp Gly Leu Gly Ser Ser Pro Arg 
                485                 490                 495     


Val Thr Ser Lys Ser Glu Ser Gln Val Thr Met Leu Gln Arg Gln Gly 
            500                 505                 510         


Phe Ser Met Arg Thr Leu Phe Cys Pro Ser Leu Leu Pro Thr Gln Gln 
        515                 520                 525             


Ser Ala Ser Leu Val Ser Phe Leu Val Gly Phe Leu Ala Phe Leu Val 
    530                 535                 540                 


Leu Gly Leu Ser Val Leu Thr Thr Tyr Gly Val His Ala Ile Thr Arg 
545                 550                 555                 560 


Leu Glu Ala Trp Ser Leu Ala Leu Leu Ala Leu Phe Leu Val Leu Phe 
                565                 570                 575     


Val Ala Ile Val Leu Thr Ile Trp Arg Leu Pro Gln Asn Gln Gln Lys 
            580                 585                 590         


Val Ala Phe Met Val Pro Phe Leu Pro Phe Leu Pro Ala Phe Ser Ile 
        595                 600                 605             


Leu Val Asn Ile Tyr Leu Met Val Gln Leu Ser Ala Asp Thr Trp Val 
    610                 615                 620                 


Arg Phe Ser Ile Trp Met Ala Ile Gly Phe Leu Ile Tyr Phe Ser Tyr 
625                 630                 635                 640 


Gly Ile Arg His Ser Leu Glu Gly His Leu Arg Asp Glu Asn Asn Glu 
                645                 650                 655     


Glu Asp Ala Tyr Pro Asp Asn Val His Ala Ala Ala Glu Glu Lys Ser 
            660                 665                 670         


Ala Ile Gln Ala Asn Asp His His Pro Arg Asn Leu Ser Ser Pro Phe 
        675                 680                 685             


Ile Phe His Glu Lys Thr Ser Glu Phe 
    690                 695         


<210>  2185
<211>  1502
<212>  DNA
<213>  Homosapiens

<400>  2185
cctgcgtccc cgccccgcgc agccgccgcg ctcctgcgct ccgaggtccg aggttcccga     60

gatgaaggtc tggctgctgc ttggtcttct gctggtgcac gaagcgctgg aggatgttac    120

tggccaacac cttcccaaga acaagcgtcc aaaagaacca ggagagaata gaatcaaacc    180

taccaacaag aaggtgaagc ccaaaattcc taaaatgaag gacagggact cagccaattc    240

agcaccaaag acgcagtcta tcatgatgca agtgctggat aaaggtcgct tccagaaacc    300

cgccgctacc ctgagtctgc tggcggggca aactgtagag cttcgatgta aagggagtag    360

aattgggtgg agctaccctg cgtatctgga cacctttaag gattctcgcc tcagcgtcaa    420

gcagaatgag cgctacggcc agttgactct ggtcaactcc acctcggcag acacaggtga    480

attcagctgc tgggtgcagc tctgcagcgg ctacatctgc aggaaggacg aggccaaaac    540

gggctccacc tacatctttt ttacagagaa aggagaactc tttgtacctt ctcccagcta    600

cttcgatgtt gtctacttga acccggacag acaggctgtg gttccttgtc gggtgaccgt    660

gctgtcggcc aaagtcacgc tccacaggga attcccagcc aaggagatcc cagccaatgg    720

aacggacatt gtttatgaca tgaagcgggg ctttgtgtat ctgcaacctc attccgagca    780

ccagggtgtg gtttactgca gggcggaggc cgggggcaga tctcagatct ccgtcaagta    840

ccagctgctc tacgtggcgg ttcccagtgg ccctccctca acaaccatct tggcttcttc    900

aaacaaagtg aaaagtgggg acgacatcag tgtgctctgc actgtcctgg gggagcccga    960

tgtggaggtg gagttcacct ggatcttccc agggcagaag gatgaaaggc ctgtgacgat   1020

ccaagacact tggaggttga tccacagagg actgggacac accacgagaa tctcccagag   1080

tgtcattaca gtggaagact tcgagacgat tgatgcagga tattacattt gcactgctca   1140

gaatcttcaa ggacagacca cagtagctac cactgttgag ttttcctgac ttggaaaagg   1200

aaatgtaatg aacttatgga aagcccattt gtgtacacag tcagctttgg ggttcctttt   1260

attagtgctt tgccagaggc tgatgtcaag caccacaccc caaccccagc gtctcgtgag   1320

tccgacccag acatccaaac taaaaggaag tcatccagtc tattcacaga agtgttaact   1380

tttctaacag aaagcatgat tttgattgct tacctacata cgtgttccta gtttttatac   1440

atgtgtaaac aattttatat aatcaatcat ttctattaaa tgagcacgtt tttgtaaaaa   1500

at                                                                  1502


<210>  2186
<211>  375
<212>  PRT
<213>  Homosapiens

<400>  2186

Met Lys Val Trp Leu Leu Leu Gly Leu Leu Leu Val His Glu Ala Leu 
1               5                   10                  15      


Glu Asp Val Thr Gly Gln His Leu Pro Lys Asn Lys Arg Pro Lys Glu 
            20                  25                  30          


Pro Gly Glu Asn Arg Ile Lys Pro Thr Asn Lys Lys Val Lys Pro Lys 
        35                  40                  45              


Ile Pro Lys Met Lys Asp Arg Asp Ser Ala Asn Ser Ala Pro Lys Thr 
    50                  55                  60                  


Gln Ser Ile Met Met Gln Val Leu Asp Lys Gly Arg Phe Gln Lys Pro 
65                  70                  75                  80  


Ala Ala Thr Leu Ser Leu Leu Ala Gly Gln Thr Val Glu Leu Arg Cys 
                85                  90                  95      


Lys Gly Ser Arg Ile Gly Trp Ser Tyr Pro Ala Tyr Leu Asp Thr Phe 
            100                 105                 110         


Lys Asp Ser Arg Leu Ser Val Lys Gln Asn Glu Arg Tyr Gly Gln Leu 
        115                 120                 125             


Thr Leu Val Asn Ser Thr Ser Ala Asp Thr Gly Glu Phe Ser Cys Trp 
    130                 135                 140                 


Val Gln Leu Cys Ser Gly Tyr Ile Cys Arg Lys Asp Glu Ala Lys Thr 
145                 150                 155                 160 


Gly Ser Thr Tyr Ile Phe Phe Thr Glu Lys Gly Glu Leu Phe Val Pro 
                165                 170                 175     


Ser Pro Ser Tyr Phe Asp Val Val Tyr Leu Asn Pro Asp Arg Gln Ala 
            180                 185                 190         


Val Val Pro Cys Arg Val Thr Val Leu Ser Ala Lys Val Thr Leu His 
        195                 200                 205             


Arg Glu Phe Pro Ala Lys Glu Ile Pro Ala Asn Gly Thr Asp Ile Val 
    210                 215                 220                 


Tyr Asp Met Lys Arg Gly Phe Val Tyr Leu Gln Pro His Ser Glu His 
225                 230                 235                 240 


Gln Gly Val Val Tyr Cys Arg Ala Glu Ala Gly Gly Arg Ser Gln Ile 
                245                 250                 255     


Ser Val Lys Tyr Gln Leu Leu Tyr Val Ala Val Pro Ser Gly Pro Pro 
            260                 265                 270         


Ser Thr Thr Ile Leu Ala Ser Ser Asn Lys Val Lys Ser Gly Asp Asp 
        275                 280                 285             


Ile Ser Val Leu Cys Thr Val Leu Gly Glu Pro Asp Val Glu Val Glu 
    290                 295                 300                 


Phe Thr Trp Ile Phe Pro Gly Gln Lys Asp Glu Arg Pro Val Thr Ile 
305                 310                 315                 320 


Gln Asp Thr Trp Arg Leu Ile His Arg Gly Leu Gly His Thr Thr Arg 
                325                 330                 335     


Ile Ser Gln Ser Val Ile Thr Val Glu Asp Phe Glu Thr Ile Asp Ala 
            340                 345                 350         


Gly Tyr Tyr Ile Cys Thr Ala Gln Asn Leu Gln Gly Gln Thr Thr Val 
        355                 360                 365             


Ala Thr Thr Val Glu Phe Ser 
    370                 375 


<210>  2187
<211>  6391
<212>  DNA
<213>  Homosapiens

<400>  2187
cgtgggccag cgcagagcct gcggaaggga cggatgcgga tctcgtcgct gtcaccttga     60

aagtgaccga ggggcttgac tgtggactcc ttacgccgcc cacccgggcc cggcggtccc    120

agccttctcg cagggcccct tctcagcaga agcaagcggg gccgagaaag cgggtggaat    180

agggttgctg caggtcccaa agacccctcg tggcgcctcg ctactttctg cagcttgttt    240

gcactttttc acgctctaga aaaatctcat cttaattaag ggaacaacaa atcatttaat    300

cttcagagca tcttagactg aaaacctttc aactgtgctg aaaaacctag aagacagacc    360

attttgccca ccctctcatt taaaaggaat tgaagaagaa ataaaatggc agaggtttaa    420

ggttactatt caggatgact gatgataatt cagatgataa aatagaagat gaattgcaaa    480

ccttctttac cagtgataaa gatggaaata cacatgcata caacccgaaa tcaccaccta    540

cacaaaactc ttcagccagc agtgtgaact ggaattctgc caacccagat gacatggtgg    600

ttgattatga aactgaccct gctgtagtta ctggtgaaaa tatttcttta agccttcagg    660

gtgttgaagt atttggtcat gaaaagtctt ctagtgattt cattagtaag caggtgttag    720

atatgcataa agattctatt tgtcagtgtc ctgcacttgt aggtactgag aagcccaaat    780

atctgcaaca cagttgtcat tccctagaag cagttgaggg ccagagtgtt gagccatctt    840

tgccttttgt gtggaagcct aatgacaatt tgaactgtgc aggctactgt gatgccttgg    900

agctaaacca aacatttgac atgacagtgg ataaagttaa ctgcaccttt atatcacatc    960

atgccatcgg aaagagtcag tccttccata ctgctggaag cctgccacca actggtagga   1020

gaagtggaag tacatcttct ttatcctatt ccacttggac atcttcccat tctgataaga   1080

cgcatgcaag agaaactact tatgatagag aaagctttga aaaccctcaa gtcacaccat   1140

cagaagccca agacatgact tacacagcat tttctgatgt ggtgatgcaa agtgaggttt   1200

ttgtttcaga tattggaaat cagtgtgcat gttcttcagg aaaggtcacc agtgagtaca   1260

cagatggatc acaacaaaga ctagttggag aaaaggagac acaagcacta acaccagttt   1320

ctgatggcat ggaagtcccc aatgattctg cattacaaga gttcttttgt ttatcccatg   1380

atgaatccaa tagcgaacca cattcacaga gctcatacag gcacaaggaa atgggccaaa   1440

atctgagaga gacagtgtcc tattgtctta ttgatgatga atgcccttta atggtgccag   1500

cttttgataa gagcgaagct caagtgctga acccagagca taaagtcact gagactgaag   1560

acacacaaat ggtctccaaa ggaaaggatt tgggaaccca aaatcatacc tcagaattga   1620

ttctaagtag cccgccagga caaaaggtgg gctcgtcatt tggactgact tgggatgcaa   1680

atgatatggt cattagcaca gacaaaacga tgtgcatgtc aacaccagtc ctagaaccca   1740

caaaagtaac cttttctgtt tcaccgattg aagcgacgga gaaatgtaag aaagtggaga   1800

agggtaatcg agggcttaaa aacataccag actcgaagga ggcacctgtg aacctgtgta   1860

aacccagttt aggaaaatca acaatcaaaa cgaatacccc aataggctgc aaagttagaa   1920

aaactgaaat tataagttac ccaagaccaa acttcaagaa tgtcaaagca aaagttatgt   1980

ctagagcagt gttgcagccc aaagatgctg ctttatcaaa ggtcacgccc agacctcagc   2040

agaccagtgc ctcatcaccc tcatcagtga attcaagaca acaaacagtc ttgagcagaa   2100

caccgagatc tgacttgaat gcagacaaaa aagcagaaat tctaattaac aagacacata   2160

agcagcagtt taataaactc attactagcc aggctgtgca tgttacaact cattctaaaa   2220

atgcttcaca cagggttcca agaacaacat ctgccgtgaa atcgaatcag gaagatgttg   2280

acaaagccag ttcttctaac tcagcatgcg agaccgggtc cgtttctgcg ttgtttcaga   2340

agatcaaagg catactccct gttaaaatgg aaagtgcaga atgtttggaa atgacctatg   2400

ttcccaacat tgataggatt agccctgaaa agaagggtga aaaagaaaat gggacatcta   2460

tggaaaaaca agagctgaaa caagagatta tgaatgagac ttttgaatat ggttctctgt   2520

ttttgggctc tgcttcaaaa acaacgacca cctcaggtag gaatatatcc aagcctgact   2580

cctgcggttt gaggcaaata gctgctccaa aagccaaagt ggggccccct gtttcctgtt   2640

tgaggcggaa cagtgacaat agaaatccca gtgctgatcg agccgtatct cctcagagga   2700

tcaggcgtgt gtccagttct ggaaagccta catccttgaa aactgcacag tcgtcatggg   2760

tgaatttgcc tagaccactt cctaaatcca aagcatcttt gaaaagtcct gcgctgcgga   2820

ggacaggaag caccccctca atagccagca cccacagtga gctgagcact tacagcaaca   2880

attctggtaa tgccgctgtc atcaaatatg aggagaaacc tccaaaacca gcatttcaga   2940

atggttcctc aggatccttt tatttgaagc ctttggtatc cagggctcat gttcacttga   3000

tgaaaactcc tccaaaaggt ccttcgagaa aaaatttatt tacagctctt aatgcagttg   3060

aaaagagcag gcaaaagaat cctcgaagct tatgtatcca gccacagaca gctcccgatg   3120

cgctgccccc tgagaaaaca cttgaattga cgcaatataa aacaaaatgt gaaaaccaaa   3180

gtggatttat cctgcagctc aagcagcttc ttgcctgtgg taataccaag tttgaggcat   3240

tgacagttgt gattcagcac ctgctgtctg agcgggagga agcactgaaa caacacaaaa   3300

ccctatctca agaacttgtt aacctccggg gagagctagt cactgcttca accacctgtg   3360

agaaattaga aaaagccagg aatgagttac aaacagtgta tgaagcattc gtccagcagc   3420

accaggctga aaaaacagaa cgagagaatc ggcttaaaga gttttacacc agggagtatg   3480

aaaagcttcg ggacacttac attgaagaag cagagaagta caaaatgcaa ttgcaagagc   3540

agtttgacaa cttaaatgct gcgcatgaaa cctctaagtt ggaaattgaa gctagccact   3600

cagagaaact tgaattgcta aagaaggcct atgaagcctc cctttcagaa attaagaaag   3660

gccatgaaat agaaaagaaa tcgcttgaag atttactttc tgagaagcag gaatcgctag   3720

agaagcaaat caatgatctg aagagtgaaa atgatgcttt aaatgaaaaa ttgaaatcag   3780

aagaacaaaa aagaagagca agagaaaaag caaatttgaa aaatcctcag atcatgtatc   3840

tagaacagga gttagaaagc ctgaaagctg tgttagagat caagaatgag aaactgcatc   3900

aacaggacat caagttaatg aaaatggaga aactggtgga caacaacaca gcattggttg   3960

acaaattgaa gcgtttccag caggagaatg aagaattgaa agctcggatg gacaagcaca   4020

tggcaatctc aaggcagctt tccacggagc aggctgttct gcaagagtcg ctggagaagg   4080

agtcgaaagt caacaagcga ctctctatgg aaaacgagga gcttctgtgg aaactgcaca   4140

atggggacct gtgtagcccc aagagatccc ccacatcctc cgccatccct ttgcagtcac   4200

caaggaattc gggctccttc cctagcccca gcatttcacc cagatgacac ctccccaaag   4260

tccacagact ctctgaaagc attttgatgc aggtctgcag gactgacccc aaggaggaac   4320

gtgggcacaa gaggtatatc agcacacgtg tgatcaccgt agggtaactg gagcgtcacc   4380

accggcggaa tcgcagcttc tgagactgga actctggagg aagacttttg cctccgtcca   4440

aaagattcct ccaaaaaaag atttaaaaaa agatttcggc atcgacacgg acgttgttgc   4500

acaaagcact taaagaacga gagcatcttg ttcattgcct ttttcaccta agcatagggg   4560

gaaaaactct cagggcccta ttaagattta taacctttgt aatgttcttc accacagaca   4620

ccttcttgtg agttttcagt ctgactgtgg gggtgggggg tgtgaatgaa atggatgtca   4680

cagagtgtca tgtgtctgat gcagcctcct ctgctgtgta ttaaatgtca aaatctgaat   4740

atatctggat atgtactaat caaataataa tcaatcaatc agcatataca tttcagccaa   4800

agccatagaa gaaaaagcaa tagttgcttg aattatgatc atctaccacc aactctgctc   4860

agccctgtaa cagggtaggg agagggtata acaggaagag ctttgacttg tccctgtcta   4920

tacattctct gtatcttttg ggggtaactt cttggcagtt tttcagtgtt cagccatgtc   4980

agttgaaact agatttttct gtagattttt tacttaccca tgtgagccta acactatcct   5040

gtaattcatt ttctcaggct atgtgtaaat gtagaaccct aatttttcta taaaaaaaca   5100

aactaactaa ctgtgtaaag aaagaaaaag ggaagtacca atgggttttt ccaccttatt   5160

tttacctttg atctaccctt gcagatttaa cctgtcttct tccctcccat tattctcatt   5220

ttccttttac ctttctccac catccagagc cacaaaagca aaccttctac ctcctaccta   5280

cttttctctg ggacaaggat aaaggaatat gattttccag agccccagag ccagctcatc   5340

ttccaggtgc tgaaaccact ttccaaataa actaaagcct ggatttgata ttacaaattt   5400

tgggaaatct tagaataaag aacgagaaca aggaagtcat tggctagtat aattaagaaa   5460

ggtaggattc agtgcttacc gatgatgcag tacttgatag aagaaaacag tctgggagga   5520

tagcgctcat ttttcagtta ccctttaagg agtccctttg tctttgggaa agtagcagaa   5580

tggtccgctt ctttcccatg agtggaaaat gtggcttgtc caactctcct ccaggttgca   5640

tttcagtttc tttccaaaac ttattacctc ccctaatcct gagactttgg aaaaggtgga   5700

aggaagaact gttgctttat ctccccctcc ctgcatgtgt caacattgtg atgtcagtat   5760

ttactaatct acattcagtg gctgtacaaa taacagctgt agtaagaaga gattcaggat   5820

gctagaggtg aatatttggg tcatttacat gtacactaca tagcaagttg atactcatgt   5880

tgcatgttct tttaaattag tgattttgtg tcttaagtct ttaacttcca atacttcatc   5940

atgtatgtaa ccttccatgt ttgcttctga taaatggaaa tgtaggttca ctgccacttc   6000

atgagatatc tctgctcacg cttccaagtt gttctcaatg acattagcca aagttgggtt   6060

tgccattcat cccctaggca tggtaaatct tgtgttgttc cctgctgtcc tccgtattac   6120

gtgaccggca aataaatctc atagcagtta atataaaaca tctttggagg atgggagaga   6180

acaggaggga agatgggaaa caaaatagag aattcttaag attttgttta aaccaaatgt   6240

ttcatgtaga atgcaaaatg ttggcacgtc aaaaatatga atgtgtagac aactgtagtt   6300

gtgctcagtt tgtagtgatg ggaagtgtat tttactctga tcaaataaat aatgctggaa   6360

tactcaagaa ttgcaaaaaa aaaaaaaaaa a                                  6391


<210>  2188
<211>  1270
<212>  PRT
<213>  Homosapiens

<400>  2188

Met Thr Asp Asp Asn Ser Asp Asp Lys Ile Glu Asp Glu Leu Gln Thr 
1               5                   10                  15      


Phe Phe Thr Ser Asp Lys Asp Gly Asn Thr His Ala Tyr Asn Pro Lys 
            20                  25                  30          


Ser Pro Pro Thr Gln Asn Ser Ser Ala Ser Ser Val Asn Trp Asn Ser 
        35                  40                  45              


Ala Asn Pro Asp Asp Met Val Val Asp Tyr Glu Thr Asp Pro Ala Val 
    50                  55                  60                  


Val Thr Gly Glu Asn Ile Ser Leu Ser Leu Gln Gly Val Glu Val Phe 
65                  70                  75                  80  


Gly His Glu Lys Ser Ser Ser Asp Phe Ile Ser Lys Gln Val Leu Asp 
                85                  90                  95      


Met His Lys Asp Ser Ile Cys Gln Cys Pro Ala Leu Val Gly Thr Glu 
            100                 105                 110         


Lys Pro Lys Tyr Leu Gln His Ser Cys His Ser Leu Glu Ala Val Glu 
        115                 120                 125             


Gly Gln Ser Val Glu Pro Ser Leu Pro Phe Val Trp Lys Pro Asn Asp 
    130                 135                 140                 


Asn Leu Asn Cys Ala Gly Tyr Cys Asp Ala Leu Glu Leu Asn Gln Thr 
145                 150                 155                 160 


Phe Asp Met Thr Val Asp Lys Val Asn Cys Thr Phe Ile Ser His His 
                165                 170                 175     


Ala Ile Gly Lys Ser Gln Ser Phe His Thr Ala Gly Ser Leu Pro Pro 
            180                 185                 190         


Thr Gly Arg Arg Ser Gly Ser Thr Ser Ser Leu Ser Tyr Ser Thr Trp 
        195                 200                 205             


Thr Ser Ser His Ser Asp Lys Thr His Ala Arg Glu Thr Thr Tyr Asp 
    210                 215                 220                 


Arg Glu Ser Phe Glu Asn Pro Gln Val Thr Pro Ser Glu Ala Gln Asp 
225                 230                 235                 240 


Met Thr Tyr Thr Ala Phe Ser Asp Val Val Met Gln Ser Glu Val Phe 
                245                 250                 255     


Val Ser Asp Ile Gly Asn Gln Cys Ala Cys Ser Ser Gly Lys Val Thr 
            260                 265                 270         


Ser Glu Tyr Thr Asp Gly Ser Gln Gln Arg Leu Val Gly Glu Lys Glu 
        275                 280                 285             


Thr Gln Ala Leu Thr Pro Val Ser Asp Gly Met Glu Val Pro Asn Asp 
    290                 295                 300                 


Ser Ala Leu Gln Glu Phe Phe Cys Leu Ser His Asp Glu Ser Asn Ser 
305                 310                 315                 320 


Glu Pro His Ser Gln Ser Ser Tyr Arg His Lys Glu Met Gly Gln Asn 
                325                 330                 335     


Leu Arg Glu Thr Val Ser Tyr Cys Leu Ile Asp Asp Glu Cys Pro Leu 
            340                 345                 350         


Met Val Pro Ala Phe Asp Lys Ser Glu Ala Gln Val Leu Asn Pro Glu 
        355                 360                 365             


His Lys Val Thr Glu Thr Glu Asp Thr Gln Met Val Ser Lys Gly Lys 
    370                 375                 380                 


Asp Leu Gly Thr Gln Asn His Thr Ser Glu Leu Ile Leu Ser Ser Pro 
385                 390                 395                 400 


Pro Gly Gln Lys Val Gly Ser Ser Phe Gly Leu Thr Trp Asp Ala Asn 
                405                 410                 415     


Asp Met Val Ile Ser Thr Asp Lys Thr Met Cys Met Ser Thr Pro Val 
            420                 425                 430         


Leu Glu Pro Thr Lys Val Thr Phe Ser Val Ser Pro Ile Glu Ala Thr 
        435                 440                 445             


Glu Lys Cys Lys Lys Val Glu Lys Gly Asn Arg Gly Leu Lys Asn Ile 
    450                 455                 460                 


Pro Asp Ser Lys Glu Ala Pro Val Asn Leu Cys Lys Pro Ser Leu Gly 
465                 470                 475                 480 


Lys Ser Thr Ile Lys Thr Asn Thr Pro Ile Gly Cys Lys Val Arg Lys 
                485                 490                 495     


Thr Glu Ile Ile Ser Tyr Pro Arg Pro Asn Phe Lys Asn Val Lys Ala 
            500                 505                 510         


Lys Val Met Ser Arg Ala Val Leu Gln Pro Lys Asp Ala Ala Leu Ser 
        515                 520                 525             


Lys Val Thr Pro Arg Pro Gln Gln Thr Ser Ala Ser Ser Pro Ser Ser 
    530                 535                 540                 


Val Asn Ser Arg Gln Gln Thr Val Leu Ser Arg Thr Pro Arg Ser Asp 
545                 550                 555                 560 


Leu Asn Ala Asp Lys Lys Ala Glu Ile Leu Ile Asn Lys Thr His Lys 
                565                 570                 575     


Gln Gln Phe Asn Lys Leu Ile Thr Ser Gln Ala Val His Val Thr Thr 
            580                 585                 590         


His Ser Lys Asn Ala Ser His Arg Val Pro Arg Thr Thr Ser Ala Val 
        595                 600                 605             


Lys Ser Asn Gln Glu Asp Val Asp Lys Ala Ser Ser Ser Asn Ser Ala 
    610                 615                 620                 


Cys Glu Thr Gly Ser Val Ser Ala Leu Phe Gln Lys Ile Lys Gly Ile 
625                 630                 635                 640 


Leu Pro Val Lys Met Glu Ser Ala Glu Cys Leu Glu Met Thr Tyr Val 
                645                 650                 655     


Pro Asn Ile Asp Arg Ile Ser Pro Glu Lys Lys Gly Glu Lys Glu Asn 
            660                 665                 670         


Gly Thr Ser Met Glu Lys Gln Glu Leu Lys Gln Glu Ile Met Asn Glu 
        675                 680                 685             


Thr Phe Glu Tyr Gly Ser Leu Phe Leu Gly Ser Ala Ser Lys Thr Thr 
    690                 695                 700                 


Thr Thr Ser Gly Arg Asn Ile Ser Lys Pro Asp Ser Cys Gly Leu Arg 
705                 710                 715                 720 


Gln Ile Ala Ala Pro Lys Ala Lys Val Gly Pro Pro Val Ser Cys Leu 
                725                 730                 735     


Arg Arg Asn Ser Asp Asn Arg Asn Pro Ser Ala Asp Arg Ala Val Ser 
            740                 745                 750         


Pro Gln Arg Ile Arg Arg Val Ser Ser Ser Gly Lys Pro Thr Ser Leu 
        755                 760                 765             


Lys Thr Ala Gln Ser Ser Trp Val Asn Leu Pro Arg Pro Leu Pro Lys 
    770                 775                 780                 


Ser Lys Ala Ser Leu Lys Ser Pro Ala Leu Arg Arg Thr Gly Ser Thr 
785                 790                 795                 800 


Pro Ser Ile Ala Ser Thr His Ser Glu Leu Ser Thr Tyr Ser Asn Asn 
                805                 810                 815     


Ser Gly Asn Ala Ala Val Ile Lys Tyr Glu Glu Lys Pro Pro Lys Pro 
            820                 825                 830         


Ala Phe Gln Asn Gly Ser Ser Gly Ser Phe Tyr Leu Lys Pro Leu Val 
        835                 840                 845             


Ser Arg Ala His Val His Leu Met Lys Thr Pro Pro Lys Gly Pro Ser 
    850                 855                 860                 


Arg Lys Asn Leu Phe Thr Ala Leu Asn Ala Val Glu Lys Ser Arg Gln 
865                 870                 875                 880 


Lys Asn Pro Arg Ser Leu Cys Ile Gln Pro Gln Thr Ala Pro Asp Ala 
                885                 890                 895     


Leu Pro Pro Glu Lys Thr Leu Glu Leu Thr Gln Tyr Lys Thr Lys Cys 
            900                 905                 910         


Glu Asn Gln Ser Gly Phe Ile Leu Gln Leu Lys Gln Leu Leu Ala Cys 
        915                 920                 925             


Gly Asn Thr Lys Phe Glu Ala Leu Thr Val Val Ile Gln His Leu Leu 
    930                 935                 940                 


Ser Glu Arg Glu Glu Ala Leu Lys Gln His Lys Thr Leu Ser Gln Glu 
945                 950                 955                 960 


Leu Val Asn Leu Arg Gly Glu Leu Val Thr Ala Ser Thr Thr Cys Glu 
                965                 970                 975     


Lys Leu Glu Lys Ala Arg Asn Glu Leu Gln Thr Val Tyr Glu Ala Phe 
            980                 985                 990         


Val Gln Gln His Gln Ala Glu Lys  Thr Glu Arg Glu Asn  Arg Leu Lys 
        995                 1000                 1005             


Glu Phe  Tyr Thr Arg Glu Tyr  Glu Lys Leu Arg Asp  Thr Tyr Ile 
    1010                 1015                 1020             


Glu Glu  Ala Glu Lys Tyr Lys  Met Gln Leu Gln Glu  Gln Phe Asp 
    1025                 1030                 1035             


Asn Leu  Asn Ala Ala His Glu  Thr Ser Lys Leu Glu  Ile Glu Ala 
    1040                 1045                 1050             


Ser His  Ser Glu Lys Leu Glu  Leu Leu Lys Lys Ala  Tyr Glu Ala 
    1055                 1060                 1065             


Ser Leu  Ser Glu Ile Lys Lys  Gly His Glu Ile Glu  Lys Lys Ser 
    1070                 1075                 1080             


Leu Glu  Asp Leu Leu Ser Glu  Lys Gln Glu Ser Leu  Glu Lys Gln 
    1085                 1090                 1095             


Ile Asn  Asp Leu Lys Ser Glu  Asn Asp Ala Leu Asn  Glu Lys Leu 
    1100                 1105                 1110             


Lys Ser  Glu Glu Gln Lys Arg  Arg Ala Arg Glu Lys  Ala Asn Leu 
    1115                 1120                 1125             


Lys Asn  Pro Gln Ile Met Tyr  Leu Glu Gln Glu Leu  Glu Ser Leu 
    1130                 1135                 1140             


Lys Ala  Val Leu Glu Ile Lys  Asn Glu Lys Leu His  Gln Gln Asp 
    1145                 1150                 1155             


Ile Lys  Leu Met Lys Met Glu  Lys Leu Val Asp Asn  Asn Thr Ala 
    1160                 1165                 1170             


Leu Val  Asp Lys Leu Lys Arg  Phe Gln Gln Glu Asn  Glu Glu Leu 
    1175                 1180                 1185             


Lys Ala  Arg Met Asp Lys His  Met Ala Ile Ser Arg  Gln Leu Ser 
    1190                 1195                 1200             


Thr Glu  Gln Ala Val Leu Gln  Glu Ser Leu Glu Lys  Glu Ser Lys 
    1205                 1210                 1215             


Val Asn  Lys Arg Leu Ser Met  Glu Asn Glu Glu Leu  Leu Trp Lys 
    1220                 1225                 1230             


Leu His  Asn Gly Asp Leu Cys  Ser Pro Lys Arg Ser  Pro Thr Ser 
    1235                 1240                 1245             


Ser Ala  Ile Pro Leu Gln Ser  Pro Arg Asn Ser Gly  Ser Phe Pro 
    1250                 1255                 1260             


Ser Pro  Ser Ile Ser Pro Arg  
    1265                 1270 


<210>  2189
<211>  6229
<212>  DNA
<213>  Homosapiens

<400>  2189
cgtgggccag cgcagagcct gcggaaggga cggatgcgga tctcgtcgct gtcaccttga     60

aagtgaccga ggggcttgac tgtggactcc ttacgccgcc cacccgggcc cggcggtccc    120

agccttctcg cagggcccct tctcagcaga agcaagcggg gccgagaaag cgggtggaat    180

agggttgctg caggtcccaa agacccctcg tggcgcctcg ctactttctg cagcttgttt    240

gcactttttc acgctctaga aaaatctcat cttaattaag ggaacaacaa atcatttaat    300

cttcagagca tcttagactg aaaacctttc aactgtgctg aaaaacctag aagacagacc    360

attttgccca ccctctcatt taaaaggaat tgaagaagaa ataaaatggc agaggtttaa    420

ggttactatt caggatgact gatgataatt cagatgataa aatagaagat gaattgcaaa    480

ccttctttac cagtgataaa gatggaaata cacatgcata caacccgaaa tcaccaccta    540

cacaaaactc ttcagccagc agtgtgaact ggaattctgc caacccagat gacatggtgg    600

ttgattatga aactgaccct gctgtagtta ctggtgaaaa tatttcttta agccttcagg    660

gtgttgaagt atttggtcat gaaaagtctt ctagtgattt cattagtaag caggtgttag    720

atatgcataa agattctatt tgtcagtgtc ctgcacttgt aggtactgag aagcccaaat    780

atctgcaaca cagttgtcat tccctagaag cagttgaggg ccagagtgtt gagccatctt    840

tgccttttgt gtggaagcct aatgacaatt tgaactgtgc aggctactgt gatgccttgg    900

agctaaacca aacatttgac atgacagtgg ataaagttaa ctgcaccttt atatcacatc    960

atgccatcgg aaagagtcag tccttccata ctgctggaag cctgccacca actggtagga   1020

gaagtggaag tacatcttct ttatcctatt ccacttggac atcttcccat tctgataaga   1080

cgcatgcaag agaaactact tatgatagag aaagctttga aaaccctcaa gtcacaccat   1140

cagaagccca agacatgact tacacagcat tttctgatgt ggtgatgcaa agtgaggttt   1200

ttgtttcaga tattggaaat cagtgtgcat gttcttcagg aaaggtcacc agtgagtaca   1260

cagatggatc acaacaaaga ctagttggag aaaaggagac acaagcacta acaccagttt   1320

ctgatggcat ggaagtcccc aatgattctg cattacaaga gttcttttgt ttatcccatg   1380

atgaatccaa tagcgaacca cattcacaga gctcatacag gcacaaggaa atgggccaaa   1440

atctgagaga gacagtgtcc tattgtctta ttgatgatga atgcccttta atggtgccag   1500

cttttgataa gagcgaagct caagtgctga acccagagca taaagtcact gagactgaag   1560

acacacaaat ggtctccaaa ggaaaggatt tgggaaccca aaatcatacc tcagaattga   1620

ttctaagtag cccgccagga caaaaggtgg gctcgtcatt tggactgact tgggatgcaa   1680

atgatatggt cattagcaca gacaaaacga tgtgcatgtc aacaccagtc ctagaaccca   1740

caaaagtaac cttttctgtt tcaccgattg aagcgacgga gaaatgtaag aaagtggaga   1800

agggtaatcg agggcttaaa aacataccag actcgaagga ggcacctgtg aacctgtgta   1860

aacccagttt aggaaaatca acaatcaaaa cgaatacccc aataggctgc aaagttagaa   1920

aaactgaaat tataagttac ccaagaccaa acttcaagaa tgtcaaagca aaagttatgt   1980

ctagagcagt gttgcagccc aaagatgctg ctttatcaaa ggtcacgccc agacctcagc   2040

agaccagtgc ctcatcaccc tcatcagtga attcaagaca acaaacagtc ttgagcagaa   2100

caccgagatc tgacttgaat gcagacaaaa aagcagaaat tctaattaac aagacacata   2160

agcagcagtt taataaactc attactagcc aggctgtgca tgttacaact cattctaaaa   2220

atgcttcaca cagggttcca agaacaacat ctgccgtgaa atcgaatcag gaagatgttg   2280

acaaagccag ttcttctaac tcagcatgcg agaccgggtc cgtttctgcg ttgtttcaga   2340

agatcaaagg catactccct gttaaaatgg aaagtgcaga atgtttggaa atgacctatg   2400

ttcccaacat tgataggatt agccctgaaa agaagggtga aaaagaaaat gggacatcta   2460

tggaaaaaca agagctgaaa caagagatta tgaatgagac ttttgaatat ggttctctgt   2520

ttttgggctc tgcttcaaaa acaacgacca cctcaggtag gaatatatcc aagcctgact   2580

cctgcggttt gaggcaaata gctgctccaa aagccaaagt ggggccccct gtttcctgtt   2640

tgaggcggaa cagtgacaat agaaatccca gtgctgatcg agccgtatct cctcagagga   2700

tcaggcgtgt gtccagttct gctggtaatg ccgctgtcat caaatatgag gagaaacctc   2760

caaaaccagc atttcagaat ggttcctcag gatcctttta tttgaagcct ttggtatcca   2820

gggctcatgt tcacttgatg aaaactcctc caaaaggtcc ttcgagaaaa aatttattta   2880

cagctcttaa tgcagttgaa aagagcaggc aaaagaatcc tcgaagctta tgtatccagc   2940

cacagacagc tcccgatgcg ctgccccctg agaaaacact tgaattgacg caatataaaa   3000

caaaatgtga aaaccaaagt ggatttatcc tgcagctcaa gcagcttctt gcctgtggta   3060

ataccaagtt tgaggcattg acagttgtga ttcagcacct gctgtctgag cgggaggaag   3120

cactgaaaca acacaaaacc ctatctcaag aacttgttaa cctccgggga gagctagtca   3180

ctgcttcaac cacctgtgag aaattagaaa aagccaggaa tgagttacaa acagtgtatg   3240

aagcattcgt ccagcagcac caggctgaaa aaacagaacg agagaatcgg cttaaagagt   3300

tttacaccag ggagtatgaa aagcttcggg acacttacat tgaagaagca gagaagtaca   3360

aaatgcaatt gcaagagcag tttgacaact taaatgctgc gcatgaaacc tctaagttgg   3420

aaattgaagc tagccactca gagaaacttg aattgctaaa gaaggcctat gaagcctccc   3480

tttcagaaat taagaaaggc catgaaatag aaaagaaatc gcttgaagat ttactttctg   3540

agaagcagga atcgctagag aagcaaatca atgatctgaa gagtgaaaat gatgctttaa   3600

atgaaaaatt gaaatcagaa gaacaaaaaa gaagagcaag agaaaaagca aatttgaaaa   3660

atcctcagat catgtatcta gaacaggagt tagaaagcct gaaagctgtg ttagagatca   3720

agaatgagaa actgcatcaa caggacatca agttaatgaa aatggagaaa ctggtggaca   3780

acaacacagc attggttgac aaattgaagc gtttccagca ggagaatgaa gaattgaaag   3840

ctcggatgga caagcacatg gcaatctcaa ggcagctttc cacggagcag gctgttctgc   3900

aagagtcgct ggagaaggag tcgaaagtca acaagcgact ctctatggaa aacgaggagc   3960

ttctgtggaa actgcacaat ggggacctgt gtagccccaa gagatccccc acatcctccg   4020

ccatcccttt gcagtcacca aggaattcgg gctccttccc tagccccagc atttcaccca   4080

gatgacacct ccccaaagtc cacagactct ctgaaagcat tttgatgcag gtctgcagga   4140

ctgaccccaa ggaggaacgt gggcacaaga ggtatatcag cacacgtgtg atcaccgtag   4200

ggtaactgga gcgtcaccac cggcggaatc gcagcttctg agactggaac tctggaggaa   4260

gacttttgcc tccgtccaaa agattcctcc aaaaaaagat ttaaaaaaag atttcggcat   4320

cgacacggac gttgttgcac aaagcactta aagaacgaga gcatcttgtt cattgccttt   4380

ttcacctaag cataggggga aaaactctca gggccctatt aagatttata acctttgtaa   4440

tgttcttcac cacagacacc ttcttgtgag ttttcagtct gactgtgggg gtggggggtg   4500

tgaatgaaat ggatgtcaca gagtgtcatg tgtctgatgc agcctcctct gctgtgtatt   4560

aaatgtcaaa atctgaatat atctggatat gtactaatca aataataatc aatcaatcag   4620

catatacatt tcagccaaag ccatagaaga aaaagcaata gttgcttgaa ttatgatcat   4680

ctaccaccaa ctctgctcag ccctgtaaca gggtagggag agggtataac aggaagagct   4740

ttgacttgtc cctgtctata cattctctgt atcttttggg ggtaacttct tggcagtttt   4800

tcagtgttca gccatgtcag ttgaaactag atttttctgt agatttttta cttacccatg   4860

tgagcctaac actatcctgt aattcatttt ctcaggctat gtgtaaatgt agaaccctaa   4920

tttttctata aaaaaacaaa ctaactaact gtgtaaagaa agaaaaaggg aagtaccaat   4980

gggtttttcc accttatttt tacctttgat ctacccttgc agatttaacc tgtcttcttc   5040

cctcccatta ttctcatttt ccttttacct ttctccacca tccagagcca caaaagcaaa   5100

ccttctacct cctacctact tttctctggg acaaggataa aggaatatga ttttccagag   5160

ccccagagcc agctcatctt ccaggtgctg aaaccacttt ccaaataaac taaagcctgg   5220

atttgatatt acaaattttg ggaaatctta gaataaagaa cgagaacaag gaagtcattg   5280

gctagtataa ttaagaaagg taggattcag tgcttaccga tgatgcagta cttgatagaa   5340

gaaaacagtc tgggaggata gcgctcattt ttcagttacc ctttaaggag tccctttgtc   5400

tttgggaaag tagcagaatg gtccgcttct ttcccatgag tggaaaatgt ggcttgtcca   5460

actctcctcc aggttgcatt tcagtttctt tccaaaactt attacctccc ctaatcctga   5520

gactttggaa aaggtggaag gaagaactgt tgctttatct ccccctccct gcatgtgtca   5580

acattgtgat gtcagtattt actaatctac attcagtggc tgtacaaata acagctgtag   5640

taagaagaga ttcaggatgc tagaggtgaa tatttgggtc atttacatgt acactacata   5700

gcaagttgat actcatgttg catgttcttt taaattagtg attttgtgtc ttaagtcttt   5760

aacttccaat acttcatcat gtatgtaacc ttccatgttt gcttctgata aatggaaatg   5820

taggttcact gccacttcat gagatatctc tgctcacgct tccaagttgt tctcaatgac   5880

attagccaaa gttgggtttg ccattcatcc cctaggcatg gtaaatcttg tgttgttccc   5940

tgctgtcctc cgtattacgt gaccggcaaa taaatctcat agcagttaat ataaaacatc   6000

tttggaggat gggagagaac aggagggaag atgggaaaca aaatagagaa ttcttaagat   6060

tttgtttaaa ccaaatgttt catgtagaat gcaaaatgtt ggcacgtcaa aaatatgaat   6120

gtgtagacaa ctgtagttgt gctcagtttg tagtgatggg aagtgtattt tactctgatc   6180

aaataaataa tgctggaata ctcaagaatt gcaaaaaaaa aaaaaaaaa               6229


<210>  2190
<211>  1216
<212>  PRT
<213>  Homosapiens

<400>  2190

Met Thr Asp Asp Asn Ser Asp Asp Lys Ile Glu Asp Glu Leu Gln Thr 
1               5                   10                  15      


Phe Phe Thr Ser Asp Lys Asp Gly Asn Thr His Ala Tyr Asn Pro Lys 
            20                  25                  30          


Ser Pro Pro Thr Gln Asn Ser Ser Ala Ser Ser Val Asn Trp Asn Ser 
        35                  40                  45              


Ala Asn Pro Asp Asp Met Val Val Asp Tyr Glu Thr Asp Pro Ala Val 
    50                  55                  60                  


Val Thr Gly Glu Asn Ile Ser Leu Ser Leu Gln Gly Val Glu Val Phe 
65                  70                  75                  80  


Gly His Glu Lys Ser Ser Ser Asp Phe Ile Ser Lys Gln Val Leu Asp 
                85                  90                  95      


Met His Lys Asp Ser Ile Cys Gln Cys Pro Ala Leu Val Gly Thr Glu 
            100                 105                 110         


Lys Pro Lys Tyr Leu Gln His Ser Cys His Ser Leu Glu Ala Val Glu 
        115                 120                 125             


Gly Gln Ser Val Glu Pro Ser Leu Pro Phe Val Trp Lys Pro Asn Asp 
    130                 135                 140                 


Asn Leu Asn Cys Ala Gly Tyr Cys Asp Ala Leu Glu Leu Asn Gln Thr 
145                 150                 155                 160 


Phe Asp Met Thr Val Asp Lys Val Asn Cys Thr Phe Ile Ser His His 
                165                 170                 175     


Ala Ile Gly Lys Ser Gln Ser Phe His Thr Ala Gly Ser Leu Pro Pro 
            180                 185                 190         


Thr Gly Arg Arg Ser Gly Ser Thr Ser Ser Leu Ser Tyr Ser Thr Trp 
        195                 200                 205             


Thr Ser Ser His Ser Asp Lys Thr His Ala Arg Glu Thr Thr Tyr Asp 
    210                 215                 220                 


Arg Glu Ser Phe Glu Asn Pro Gln Val Thr Pro Ser Glu Ala Gln Asp 
225                 230                 235                 240 


Met Thr Tyr Thr Ala Phe Ser Asp Val Val Met Gln Ser Glu Val Phe 
                245                 250                 255     


Val Ser Asp Ile Gly Asn Gln Cys Ala Cys Ser Ser Gly Lys Val Thr 
            260                 265                 270         


Ser Glu Tyr Thr Asp Gly Ser Gln Gln Arg Leu Val Gly Glu Lys Glu 
        275                 280                 285             


Thr Gln Ala Leu Thr Pro Val Ser Asp Gly Met Glu Val Pro Asn Asp 
    290                 295                 300                 


Ser Ala Leu Gln Glu Phe Phe Cys Leu Ser His Asp Glu Ser Asn Ser 
305                 310                 315                 320 


Glu Pro His Ser Gln Ser Ser Tyr Arg His Lys Glu Met Gly Gln Asn 
                325                 330                 335     


Leu Arg Glu Thr Val Ser Tyr Cys Leu Ile Asp Asp Glu Cys Pro Leu 
            340                 345                 350         


Met Val Pro Ala Phe Asp Lys Ser Glu Ala Gln Val Leu Asn Pro Glu 
        355                 360                 365             


His Lys Val Thr Glu Thr Glu Asp Thr Gln Met Val Ser Lys Gly Lys 
    370                 375                 380                 


Asp Leu Gly Thr Gln Asn His Thr Ser Glu Leu Ile Leu Ser Ser Pro 
385                 390                 395                 400 


Pro Gly Gln Lys Val Gly Ser Ser Phe Gly Leu Thr Trp Asp Ala Asn 
                405                 410                 415     


Asp Met Val Ile Ser Thr Asp Lys Thr Met Cys Met Ser Thr Pro Val 
            420                 425                 430         


Leu Glu Pro Thr Lys Val Thr Phe Ser Val Ser Pro Ile Glu Ala Thr 
        435                 440                 445             


Glu Lys Cys Lys Lys Val Glu Lys Gly Asn Arg Gly Leu Lys Asn Ile 
    450                 455                 460                 


Pro Asp Ser Lys Glu Ala Pro Val Asn Leu Cys Lys Pro Ser Leu Gly 
465                 470                 475                 480 


Lys Ser Thr Ile Lys Thr Asn Thr Pro Ile Gly Cys Lys Val Arg Lys 
                485                 490                 495     


Thr Glu Ile Ile Ser Tyr Pro Arg Pro Asn Phe Lys Asn Val Lys Ala 
            500                 505                 510         


Lys Val Met Ser Arg Ala Val Leu Gln Pro Lys Asp Ala Ala Leu Ser 
        515                 520                 525             


Lys Val Thr Pro Arg Pro Gln Gln Thr Ser Ala Ser Ser Pro Ser Ser 
    530                 535                 540                 


Val Asn Ser Arg Gln Gln Thr Val Leu Ser Arg Thr Pro Arg Ser Asp 
545                 550                 555                 560 


Leu Asn Ala Asp Lys Lys Ala Glu Ile Leu Ile Asn Lys Thr His Lys 
                565                 570                 575     


Gln Gln Phe Asn Lys Leu Ile Thr Ser Gln Ala Val His Val Thr Thr 
            580                 585                 590         


His Ser Lys Asn Ala Ser His Arg Val Pro Arg Thr Thr Ser Ala Val 
        595                 600                 605             


Lys Ser Asn Gln Glu Asp Val Asp Lys Ala Ser Ser Ser Asn Ser Ala 
    610                 615                 620                 


Cys Glu Thr Gly Ser Val Ser Ala Leu Phe Gln Lys Ile Lys Gly Ile 
625                 630                 635                 640 


Leu Pro Val Lys Met Glu Ser Ala Glu Cys Leu Glu Met Thr Tyr Val 
                645                 650                 655     


Pro Asn Ile Asp Arg Ile Ser Pro Glu Lys Lys Gly Glu Lys Glu Asn 
            660                 665                 670         


Gly Thr Ser Met Glu Lys Gln Glu Leu Lys Gln Glu Ile Met Asn Glu 
        675                 680                 685             


Thr Phe Glu Tyr Gly Ser Leu Phe Leu Gly Ser Ala Ser Lys Thr Thr 
    690                 695                 700                 


Thr Thr Ser Gly Arg Asn Ile Ser Lys Pro Asp Ser Cys Gly Leu Arg 
705                 710                 715                 720 


Gln Ile Ala Ala Pro Lys Ala Lys Val Gly Pro Pro Val Ser Cys Leu 
                725                 730                 735     


Arg Arg Asn Ser Asp Asn Arg Asn Pro Ser Ala Asp Arg Ala Val Ser 
            740                 745                 750         


Pro Gln Arg Ile Arg Arg Val Ser Ser Ser Ala Gly Asn Ala Ala Val 
        755                 760                 765             


Ile Lys Tyr Glu Glu Lys Pro Pro Lys Pro Ala Phe Gln Asn Gly Ser 
    770                 775                 780                 


Ser Gly Ser Phe Tyr Leu Lys Pro Leu Val Ser Arg Ala His Val His 
785                 790                 795                 800 


Leu Met Lys Thr Pro Pro Lys Gly Pro Ser Arg Lys Asn Leu Phe Thr 
                805                 810                 815     


Ala Leu Asn Ala Val Glu Lys Ser Arg Gln Lys Asn Pro Arg Ser Leu 
            820                 825                 830         


Cys Ile Gln Pro Gln Thr Ala Pro Asp Ala Leu Pro Pro Glu Lys Thr 
        835                 840                 845             


Leu Glu Leu Thr Gln Tyr Lys Thr Lys Cys Glu Asn Gln Ser Gly Phe 
    850                 855                 860                 


Ile Leu Gln Leu Lys Gln Leu Leu Ala Cys Gly Asn Thr Lys Phe Glu 
865                 870                 875                 880 


Ala Leu Thr Val Val Ile Gln His Leu Leu Ser Glu Arg Glu Glu Ala 
                885                 890                 895     


Leu Lys Gln His Lys Thr Leu Ser Gln Glu Leu Val Asn Leu Arg Gly 
            900                 905                 910         


Glu Leu Val Thr Ala Ser Thr Thr Cys Glu Lys Leu Glu Lys Ala Arg 
        915                 920                 925             


Asn Glu Leu Gln Thr Val Tyr Glu Ala Phe Val Gln Gln His Gln Ala 
    930                 935                 940                 


Glu Lys Thr Glu Arg Glu Asn Arg Leu Lys Glu Phe Tyr Thr Arg Glu 
945                 950                 955                 960 


Tyr Glu Lys Leu Arg Asp Thr Tyr Ile Glu Glu Ala Glu Lys Tyr Lys 
                965                 970                 975     


Met Gln Leu Gln Glu Gln Phe Asp Asn Leu Asn Ala Ala His Glu Thr 
            980                 985                 990         


Ser Lys Leu Glu Ile Glu Ala Ser  His Ser Glu Lys Leu  Glu Leu Leu 
        995                 1000                 1005             


Lys Lys  Ala Tyr Glu Ala Ser  Leu Ser Glu Ile Lys  Lys Gly His 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ser Leu  Glu Asp Leu Leu Ser  Glu Lys Gln 
    1025                 1030                 1035             


Glu Ser  Leu Glu Lys Gln Ile  Asn Asp Leu Lys Ser  Glu Asn Asp 
    1040                 1045                 1050             


Ala Leu  Asn Glu Lys Leu Lys  Ser Glu Glu Gln Lys  Arg Arg Ala 
    1055                 1060                 1065             


Arg Glu  Lys Ala Asn Leu Lys  Asn Pro Gln Ile Met  Tyr Leu Glu 
    1070                 1075                 1080             


Gln Glu  Leu Glu Ser Leu Lys  Ala Val Leu Glu Ile  Lys Asn Glu 
    1085                 1090                 1095             


Lys Leu  His Gln Gln Asp Ile  Lys Leu Met Lys Met  Glu Lys Leu 
    1100                 1105                 1110             


Val Asp  Asn Asn Thr Ala Leu  Val Asp Lys Leu Lys  Arg Phe Gln 
    1115                 1120                 1125             


Gln Glu  Asn Glu Glu Leu Lys  Ala Arg Met Asp Lys  His Met Ala 
    1130                 1135                 1140             


Ile Ser  Arg Gln Leu Ser Thr  Glu Gln Ala Val Leu  Gln Glu Ser 
    1145                 1150                 1155             


Leu Glu  Lys Glu Ser Lys Val  Asn Lys Arg Leu Ser  Met Glu Asn 
    1160                 1165                 1170             


Glu Glu  Leu Leu Trp Lys Leu  His Asn Gly Asp Leu  Cys Ser Pro 
    1175                 1180                 1185             


Lys Arg  Ser Pro Thr Ser Ser  Ala Ile Pro Leu Gln  Ser Pro Arg 
    1190                 1195                 1200             


Asn Ser  Gly Ser Phe Pro Ser  Pro Ser Ile Ser Pro  Arg 
    1205                 1210                 1215     


<210>  2191
<211>  6452
<212>  DNA
<213>  Homosapiens

<400>  2191
cgtgggccag cgcagagcct gcggaaggga cggatgcgga tctcgtcgct gtcaccttga     60

aagtgaccga ggggcttgac tgtggactcc ttacgccgcc cacccgggcc cggcggtccc    120

agccttctcg cagggcccct tctcagcaga agcaagcggg gccgagaaag cgggtggaat    180

agggttgctg caggtcccaa agacccctcg tggcgcctcg ctactttctg cagcttgttt    240

gcactttttc acgctctaga aaaatctcat cttaattaag ggaacaacaa atcatttaat    300

cttcagagca tcttagactg aaaacctttc aactgtgctg aaaaacctag aagacagacc    360

attttgccca ccctctcatt taaaaggaat tgaagaagaa ataaaatggc agaggtttaa    420

ggttactatt caggatgact gatgataatt cagatgataa aatagaagat gaattgcaaa    480

ccttctttac cagtgataaa gatggaaata cacatgcata caacccgaaa tcaccaccta    540

cacaaaactc ttcagccagc agtgtgaact ggaattctgc caacccagat gacatggtgg    600

ttgattatga aactgaccct gctgtagtta ctggtgaaaa tatttcttta agccttcagg    660

gtgttgaagt atttggtcat gaaaagtctt ctagtgattt cattagtaag caggtgttag    720

atatgcataa agattctatt tgtcagtgtc ctgcacttgt aggtactgag aagcccaaat    780

atctgcaaca cagttgtcat tccctagaag cagttgaggg ccagagtgtt gagccatctt    840

tgccttttgt gtggaagcct aatgacaatt tgaactgtgc aggctactgt gatgccttgg    900

agctaaacca aacatttgac atgacagtgg ataaagttaa ctgcaccttt atatcacatc    960

atgccatcgg aaagagtcag tccttccata ctgctggaag cctgccacca actggtagga   1020

gaagtggaag tacatcttct ttatcctatt ccacttggac atcttcccat tctgataaga   1080

cgcatgcaag agaaactact tatgatagag aaagctttga aaaccctcaa gtcacaccat   1140

cagaagccca agacatgact tacacagcat tttctgatgt ggtgatgcaa agtgaggttt   1200

ttgtttcaga tattggaaat cagtgtgcat gttcttcagg aaaggtcacc agtgagtaca   1260

cagatggatc acaacaaaga ctagttggag aaaaggagac acaagcacta acaccagttt   1320

ctgatggcat ggaagtcccc aatgattctg cattacaaga gttcttttgt ttatcccatg   1380

atgaatccaa tagcgaacca cattcacaga gctcatacag gcacaaggaa atgggccaaa   1440

atctgagaga gacagtgtcc tattgtctta ttgatgatga atgcccttta atggtgccag   1500

cttttgataa gagcgaagct caagtgctga acccagagca taaagtcact gagactgaag   1560

acacacaaat ggtctccaaa ggaaaggatt tgggaaccca aaatcatacc tcagaattga   1620

ttctaagtag cccgccagga caaaaggtgg gctcgtcatt tggactgact tgggatgcaa   1680

atgatatggt cattagcaca gacaaaacga tgtgcatgtc aacaccagtc ctagaaccca   1740

caaaagtaac cttttctgtt tcaccgattg aagcgacgga gaaatgtaag aaagtggaga   1800

agggtaatcg agggcttaaa aacataccag actcgaagga ggcacctgtg aacctgtgta   1860

aacccagttt aggaaaatca acaatcaaaa cgaatacccc aataggctgc aaagttagaa   1920

aaactgaaat tataagttac ccaagaccaa acttcaagaa tgtcaaagca aaagttatgt   1980

ctagagcagt gttgcagccc aaagatgctg ctttatcaaa ggtcacgccc agacctcagc   2040

agaccagtgc ctcatcaccc tcatcagtga attcaagaca acaaacagtc ttgagcagaa   2100

caccgagatc tgacttgaat gcagacaaaa aagcagaaat tctaattaac aagacacata   2160

agcagcagtt taataaactc attactagcc aggctgtgca tgttacaact cattctaaaa   2220

atgcttcaca cagggttcca agaacaacat ctgccgtgaa atcgaatcag gaagatgttg   2280

acaaagccag ttcttctaac tcagcatgcg agaccgggtc cgtttctgcg ttgtttcaga   2340

agatcaaagg catactccct gttaaaatgg aaagtgcaga atgtttggaa atgacctatg   2400

ttcccaacat tgataggatt agccctgaaa agaagggtga aaaagaaaat gggacatcta   2460

tggaaaaaca agagctgaaa caagagatta tgaatgagac ttttgaatat ggttctctgt   2520

ttttgggctc tgcttcaaaa acaacgacca cctcaggtag gaatatatcc aagcctgact   2580

cctgcggttt gaggcaaata gctgctccaa aagccaaagt ggggccccct gtttcctgtt   2640

tgaggcggaa cagtgacaat agaaatccca gtgctgatcg agccgtatct cctcagagga   2700

tcaggcgtgt gtccagttct gttttgccaa aagctgcttt ctcatgatta ttctgattga   2760

tcatctcctt cagagaacat gtgaaagcct acatccttga aaactgcaca gtcgtcatgg   2820

gtgaatttgc ctagaccact tcctaaatcc aaagcatctt tgaaaagtcc tgcgctgcgg   2880

aggacaggaa gcaccccctc aatagccagc acccacagtg agctgagcac ttacagcaac   2940

aattctggta atgccgctgt catcaaatat gaggagaaac ctccaaaacc agcatttcag   3000

aatggttcct caggatcctt ttatttgaag cctttggtat ccagggctca tgttcacttg   3060

atgaaaactc ctccaaaagg tccttcgaga aaaaatttat ttacagctct taatgcagtt   3120

gaaaagagca ggcaaaagaa tcctcgaagc ttatgtatcc agccacagac agctcccgat   3180

gcgctgcccc ctgagaaaac acttgaattg acgcaatata aaacaaaatg tgaaaaccaa   3240

agtggattta tcctgcagct caagcagctt cttgcctgtg gtaataccaa gtttgaggca   3300

ttgacagttg tgattcagca cctgctgtct gagcgggagg aagcactgaa acaacacaaa   3360

accctatctc aagaacttgt taacctccgg ggagagctag tcactgcttc aaccacctgt   3420

gagaaattag aaaaagccag gaatgagtta caaacagtgt atgaagcatt cgtccagcag   3480

caccaggctg aaaaaacaga acgagagaat cggcttaaag agttttacac cagggagtat   3540

gaaaagcttc gggacactta cattgaagaa gcagagaagt acaaaatgca attgcaagag   3600

cagtttgaca acttaaatgc tgcgcatgaa acctctaagt tggaaattga agctagccac   3660

tcagagaaac ttgaattgct aaagaaggcc tatgaagcct ccctttcaga aattaagaaa   3720

ggccatgaaa tagaaaagaa atcgcttgaa gatttacttt ctgagaagca ggaatcgcta   3780

gagaagcaaa tcaatgatct gaagagtgaa aatgatgctt taaatgaaaa attgaaatca   3840

gaagaacaaa aaagaagagc aagagaaaaa gcaaatttga aaaatcctca gatcatgtat   3900

ctagaacagg agttagaaag cctgaaagct gtgttagaga tcaagaatga gaaactgcat   3960

caacaggaca tcaagttaat gaaaatggag aaactggtgg acaacaacac agcattggtt   4020

gacaaattga agcgtttcca gcaggagaat gaagaattga aagctcggat ggacaagcac   4080

atggcaatct caaggcagct ttccacggag caggctgttc tgcaagagtc gctggagaag   4140

gagtcgaaag tcaacaagcg actctctatg gaaaacgagg agcttctgtg gaaactgcac   4200

aatggggacc tgtgtagccc caagagatcc cccacatcct ccgccatccc tttgcagtca   4260

ccaaggaatt cgggctcctt ccctagcccc agcatttcac ccagatgaca cctccccaaa   4320

gtccacagac tctctgaaag cattttgatg caggtctgca ggactgaccc caaggaggaa   4380

cgtgggcaca agaggtatat cagcacacgt gtgatcaccg tagggtaact ggagcgtcac   4440

caccggcgga atcgcagctt ctgagactgg aactctggag gaagactttt gcctccgtcc   4500

aaaagattcc tccaaaaaaa gatttaaaaa aagatttcgg catcgacacg gacgttgttg   4560

cacaaagcac ttaaagaacg agagcatctt gttcattgcc tttttcacct aagcataggg   4620

ggaaaaactc tcagggccct attaagattt ataacctttg taatgttctt caccacagac   4680

accttcttgt gagttttcag tctgactgtg ggggtggggg gtgtgaatga aatggatgtc   4740

acagagtgtc atgtgtctga tgcagcctcc tctgctgtgt attaaatgtc aaaatctgaa   4800

tatatctgga tatgtactaa tcaaataata atcaatcaat cagcatatac atttcagcca   4860

aagccataga agaaaaagca atagttgctt gaattatgat catctaccac caactctgct   4920

cagccctgta acagggtagg gagagggtat aacaggaaga gctttgactt gtccctgtct   4980

atacattctc tgtatctttt gggggtaact tcttggcagt ttttcagtgt tcagccatgt   5040

cagttgaaac tagatttttc tgtagatttt ttacttaccc atgtgagcct aacactatcc   5100

tgtaattcat tttctcaggc tatgtgtaaa tgtagaaccc taatttttct ataaaaaaac   5160

aaactaacta actgtgtaaa gaaagaaaaa gggaagtacc aatgggtttt tccaccttat   5220

ttttaccttt gatctaccct tgcagattta acctgtcttc ttccctccca ttattctcat   5280

tttcctttta cctttctcca ccatccagag ccacaaaagc aaaccttcta cctcctacct   5340

acttttctct gggacaagga taaaggaata tgattttcca gagccccaga gccagctcat   5400

cttccaggtg ctgaaaccac tttccaaata aactaaagcc tggatttgat attacaaatt   5460

ttgggaaatc ttagaataaa gaacgagaac aaggaagtca ttggctagta taattaagaa   5520

aggtaggatt cagtgcttac cgatgatgca gtacttgata gaagaaaaca gtctgggagg   5580

atagcgctca tttttcagtt accctttaag gagtcccttt gtctttggga aagtagcaga   5640

atggtccgct tctttcccat gagtggaaaa tgtggcttgt ccaactctcc tccaggttgc   5700

atttcagttt ctttccaaaa cttattacct cccctaatcc tgagactttg gaaaaggtgg   5760

aaggaagaac tgttgcttta tctccccctc cctgcatgtg tcaacattgt gatgtcagta   5820

tttactaatc tacattcagt ggctgtacaa ataacagctg tagtaagaag agattcagga   5880

tgctagaggt gaatatttgg gtcatttaca tgtacactac atagcaagtt gatactcatg   5940

ttgcatgttc ttttaaatta gtgattttgt gtcttaagtc tttaacttcc aatacttcat   6000

catgtatgta accttccatg tttgcttctg ataaatggaa atgtaggttc actgccactt   6060

catgagatat ctctgctcac gcttccaagt tgttctcaat gacattagcc aaagttgggt   6120

ttgccattca tcccctaggc atggtaaatc ttgtgttgtt ccctgctgtc ctccgtatta   6180

cgtgaccggc aaataaatct catagcagtt aatataaaac atctttggag gatgggagag   6240

aacaggaggg aagatgggaa acaaaataga gaattcttaa gattttgttt aaaccaaatg   6300

tttcatgtag aatgcaaaat gttggcacgt caaaaatatg aatgtgtaga caactgtagt   6360

tgtgctcagt ttgtagtgat gggaagtgta ttttactctg atcaaataaa taatgctgga   6420

atactcaaga attgcaaaaa aaaaaaaaaa aa                                 6452


<210>  2192
<211>  770
<212>  PRT
<213>  Homosapiens

<400>  2192

Met Thr Asp Asp Asn Ser Asp Asp Lys Ile Glu Asp Glu Leu Gln Thr 
1               5                   10                  15      


Phe Phe Thr Ser Asp Lys Asp Gly Asn Thr His Ala Tyr Asn Pro Lys 
            20                  25                  30          


Ser Pro Pro Thr Gln Asn Ser Ser Ala Ser Ser Val Asn Trp Asn Ser 
        35                  40                  45              


Ala Asn Pro Asp Asp Met Val Val Asp Tyr Glu Thr Asp Pro Ala Val 
    50                  55                  60                  


Val Thr Gly Glu Asn Ile Ser Leu Ser Leu Gln Gly Val Glu Val Phe 
65                  70                  75                  80  


Gly His Glu Lys Ser Ser Ser Asp Phe Ile Ser Lys Gln Val Leu Asp 
                85                  90                  95      


Met His Lys Asp Ser Ile Cys Gln Cys Pro Ala Leu Val Gly Thr Glu 
            100                 105                 110         


Lys Pro Lys Tyr Leu Gln His Ser Cys His Ser Leu Glu Ala Val Glu 
        115                 120                 125             


Gly Gln Ser Val Glu Pro Ser Leu Pro Phe Val Trp Lys Pro Asn Asp 
    130                 135                 140                 


Asn Leu Asn Cys Ala Gly Tyr Cys Asp Ala Leu Glu Leu Asn Gln Thr 
145                 150                 155                 160 


Phe Asp Met Thr Val Asp Lys Val Asn Cys Thr Phe Ile Ser His His 
                165                 170                 175     


Ala Ile Gly Lys Ser Gln Ser Phe His Thr Ala Gly Ser Leu Pro Pro 
            180                 185                 190         


Thr Gly Arg Arg Ser Gly Ser Thr Ser Ser Leu Ser Tyr Ser Thr Trp 
        195                 200                 205             


Thr Ser Ser His Ser Asp Lys Thr His Ala Arg Glu Thr Thr Tyr Asp 
    210                 215                 220                 


Arg Glu Ser Phe Glu Asn Pro Gln Val Thr Pro Ser Glu Ala Gln Asp 
225                 230                 235                 240 


Met Thr Tyr Thr Ala Phe Ser Asp Val Val Met Gln Ser Glu Val Phe 
                245                 250                 255     


Val Ser Asp Ile Gly Asn Gln Cys Ala Cys Ser Ser Gly Lys Val Thr 
            260                 265                 270         


Ser Glu Tyr Thr Asp Gly Ser Gln Gln Arg Leu Val Gly Glu Lys Glu 
        275                 280                 285             


Thr Gln Ala Leu Thr Pro Val Ser Asp Gly Met Glu Val Pro Asn Asp 
    290                 295                 300                 


Ser Ala Leu Gln Glu Phe Phe Cys Leu Ser His Asp Glu Ser Asn Ser 
305                 310                 315                 320 


Glu Pro His Ser Gln Ser Ser Tyr Arg His Lys Glu Met Gly Gln Asn 
                325                 330                 335     


Leu Arg Glu Thr Val Ser Tyr Cys Leu Ile Asp Asp Glu Cys Pro Leu 
            340                 345                 350         


Met Val Pro Ala Phe Asp Lys Ser Glu Ala Gln Val Leu Asn Pro Glu 
        355                 360                 365             


His Lys Val Thr Glu Thr Glu Asp Thr Gln Met Val Ser Lys Gly Lys 
    370                 375                 380                 


Asp Leu Gly Thr Gln Asn His Thr Ser Glu Leu Ile Leu Ser Ser Pro 
385                 390                 395                 400 


Pro Gly Gln Lys Val Gly Ser Ser Phe Gly Leu Thr Trp Asp Ala Asn 
                405                 410                 415     


Asp Met Val Ile Ser Thr Asp Lys Thr Met Cys Met Ser Thr Pro Val 
            420                 425                 430         


Leu Glu Pro Thr Lys Val Thr Phe Ser Val Ser Pro Ile Glu Ala Thr 
        435                 440                 445             


Glu Lys Cys Lys Lys Val Glu Lys Gly Asn Arg Gly Leu Lys Asn Ile 
    450                 455                 460                 


Pro Asp Ser Lys Glu Ala Pro Val Asn Leu Cys Lys Pro Ser Leu Gly 
465                 470                 475                 480 


Lys Ser Thr Ile Lys Thr Asn Thr Pro Ile Gly Cys Lys Val Arg Lys 
                485                 490                 495     


Thr Glu Ile Ile Ser Tyr Pro Arg Pro Asn Phe Lys Asn Val Lys Ala 
            500                 505                 510         


Lys Val Met Ser Arg Ala Val Leu Gln Pro Lys Asp Ala Ala Leu Ser 
        515                 520                 525             


Lys Val Thr Pro Arg Pro Gln Gln Thr Ser Ala Ser Ser Pro Ser Ser 
    530                 535                 540                 


Val Asn Ser Arg Gln Gln Thr Val Leu Ser Arg Thr Pro Arg Ser Asp 
545                 550                 555                 560 


Leu Asn Ala Asp Lys Lys Ala Glu Ile Leu Ile Asn Lys Thr His Lys 
                565                 570                 575     


Gln Gln Phe Asn Lys Leu Ile Thr Ser Gln Ala Val His Val Thr Thr 
            580                 585                 590         


His Ser Lys Asn Ala Ser His Arg Val Pro Arg Thr Thr Ser Ala Val 
        595                 600                 605             


Lys Ser Asn Gln Glu Asp Val Asp Lys Ala Ser Ser Ser Asn Ser Ala 
    610                 615                 620                 


Cys Glu Thr Gly Ser Val Ser Ala Leu Phe Gln Lys Ile Lys Gly Ile 
625                 630                 635                 640 


Leu Pro Val Lys Met Glu Ser Ala Glu Cys Leu Glu Met Thr Tyr Val 
                645                 650                 655     


Pro Asn Ile Asp Arg Ile Ser Pro Glu Lys Lys Gly Glu Lys Glu Asn 
            660                 665                 670         


Gly Thr Ser Met Glu Lys Gln Glu Leu Lys Gln Glu Ile Met Asn Glu 
        675                 680                 685             


Thr Phe Glu Tyr Gly Ser Leu Phe Leu Gly Ser Ala Ser Lys Thr Thr 
    690                 695                 700                 


Thr Thr Ser Gly Arg Asn Ile Ser Lys Pro Asp Ser Cys Gly Leu Arg 
705                 710                 715                 720 


Gln Ile Ala Ala Pro Lys Ala Lys Val Gly Pro Pro Val Ser Cys Leu 
                725                 730                 735     


Arg Arg Asn Ser Asp Asn Arg Asn Pro Ser Ala Asp Arg Ala Val Ser 
            740                 745                 750         


Pro Gln Arg Ile Arg Arg Val Ser Ser Ser Val Leu Pro Lys Ala Ala 
        755                 760                 765             


Phe Ser 
    770 


<210>  2193
<211>  4018
<212>  DNA
<213>  Homosapiens

<400>  2193
agtactgtgt ctgatgctcc taaggaggct gtaaagtgct tttgtccatt cctttttgtc     60

ttttaacaaa ggggtttacc atacacccac agagcctgtc tagtggcgat gtgttcctgt    120

tgcggattaa gcattcaaat cagtgagtct ctttcttagt ttgatttgct agctggttta    180

atctgttttg tgtagtgcct tggagcttac gcattttttt ttttttccct ccattcgaat    240

tcactaagag caagcatgag ggatatgaga gtgaacatgg ctgcagtttt tcctgcttaa    300

gcttgctttg atccttttaa atgactgtac caggaggatt tcgcagttgt acagaaactg    360

atatttcttc aaaaatcttt atcaattcta cactcacccc accggctggt tcagagaggc    420

actatgatgc taccttattg acactgctgg tcgtgggatc gtacagcctt tgtataattc    480

ctttgttagc cacgtttact gggaaaaaaa ctggtaatgc cgctgtcatc aaatatgagg    540

agaaacctcc aaaaccagca tttcagaatg gttcctcagg atccttttat ttgaagcctt    600

tggtatccag ggctcatgtt cacttgatga aaactcctcc aaaaggtcct tcgagaaaaa    660

atttatttac agctcttaat gcagttgaaa agagcaggca aaagaatcct cgaagcttat    720

gtatccagcc acagacagct cccgatgcgc tgccccctga gaaaacactt gaattgacgc    780

aatataaaac aaaatgtgaa aaccaaagtg gatttatcct gcagctcaag cagcttcttg    840

cctgtggtaa taccaagttt gaggcattga cagttgtgat tcagcacctg ctgtctgagc    900

gggaggaagc actgaaacaa cacaaaaccc tatctcaaga acttgttaac ctccggggag    960

agctagtcac tgcttcaacc acctgtgaga aattagaaaa agccaggaat gagttacaaa   1020

cagtgtatga agcattcgtc cagcagcacc aggctgaaaa aacagaacga gagaatcggc   1080

ttaaagagtt ttacaccagg gagtatgaaa agcttcggga cacttacatt gaagaagcag   1140

agaagtacaa aatgcaattg caagagcagt ttgacaactt aaatgctgcg catgaaacct   1200

ctaagttgga aattgaagct agccactcag agaaacttga attgctaaag aaggcctatg   1260

aagcctccct ttcagaaatt aagaaaggcc atgaaataga aaagaaatcg cttgaagatt   1320

tactttctga gaagcaggaa tcgctagaga agcaaatcaa tgatctgaag agtgaaaatg   1380

atgctttaaa tgaaaaattg aaatcagaag aacaaaaaag aagagcaaga gaaaaagcaa   1440

atttgaaaaa tcctcagatc atgtatctag aacaggagtt agaaagcctg aaagctgtgt   1500

tagagatcaa gaatgagaaa ctgcatcaac aggacatcaa gttaatgaaa atggagaaac   1560

tggtggacaa caacacagca ttggttgaca aattgaagcg tttccagcag gagaatgaag   1620

aattgaaagc tcggatggac aagcacatgg caatctcaag gcagctttcc acggagcagg   1680

ctgttctgca agagtcgctg gagaaggagt cgaaagtcaa caagcgactc tctatggaaa   1740

acgaggagct tctgtggaaa ctgcacaatg gggacctgtg tagccccaag agatccccca   1800

catcctccgc catccctttg cagtcaccaa ggaattcggg ctccttccct agccccagca   1860

tttcacccag atgacacctc cccaaagtcc acagactctc tgaaagcatt ttgatgcagg   1920

tctgcaggac tgaccccaag gaggaacgtg ggcacaagag gtatatcagc acacgtgtga   1980

tcaccgtagg gtaactggag cgtcaccacc ggcggaatcg cagcttctga gactggaact   2040

ctggaggaag acttttgcct ccgtccaaaa gattcctcca aaaaaagatt taaaaaaaga   2100

tttcggcatc gacacggacg ttgttgcaca aagcacttaa agaacgagag catcttgttc   2160

attgcctttt tcacctaagc atagggggaa aaactctcag ggccctatta agatttataa   2220

cctttgtaat gttcttcacc acagacacct tcttgtgagt tttcagtctg actgtggggg   2280

tggggggtgt gaatgaaatg gatgtcacag agtgtcatgt gtctgatgca gcctcctctg   2340

ctgtgtatta aatgtcaaaa tctgaatata tctggatatg tactaatcaa ataataatca   2400

atcaatcagc atatacattt cagccaaagc catagaagaa aaagcaatag ttgcttgaat   2460

tatgatcatc taccaccaac tctgctcagc cctgtaacag ggtagggaga gggtataaca   2520

ggaagagctt tgacttgtcc ctgtctatac attctctgta tcttttgggg gtaacttctt   2580

ggcagttttt cagtgttcag ccatgtcagt tgaaactaga tttttctgta gattttttac   2640

ttacccatgt gagcctaaca ctatcctgta attcattttc tcaggctatg tgtaaatgta   2700

gaaccctaat ttttctataa aaaaacaaac taactaactg tgtaaagaaa gaaaaaggga   2760

agtaccaatg ggtttttcca ccttattttt acctttgatc tacccttgca gatttaacct   2820

gtcttcttcc ctcccattat tctcattttc cttttacctt tctccaccat ccagagccac   2880

aaaagcaaac cttctacctc ctacctactt ttctctggga caaggataaa ggaatatgat   2940

tttccagagc cccagagcca gctcatcttc caggtgctga aaccactttc caaataaact   3000

aaagcctgga tttgatatta caaattttgg gaaatcttag aataaagaac gagaacaagg   3060

aagtcattgg ctagtataat taagaaaggt aggattcagt gcttaccgat gatgcagtac   3120

ttgatagaag aaaacagtct gggaggatag cgctcatttt tcagttaccc tttaaggagt   3180

ccctttgtct ttgggaaagt agcagaatgg tccgcttctt tcccatgagt ggaaaatgtg   3240

gcttgtccaa ctctcctcca ggttgcattt cagtttcttt ccaaaactta ttacctcccc   3300

taatcctgag actttggaaa aggtggaagg aagaactgtt gctttatctc cccctccctg   3360

catgtgtcaa cattgtgatg tcagtattta ctaatctaca ttcagtggct gtacaaataa   3420

cagctgtagt aagaagagat tcaggatgct agaggtgaat atttgggtca tttacatgta   3480

cactacatag caagttgata ctcatgttgc atgttctttt aaattagtga ttttgtgtct   3540

taagtcttta acttccaata cttcatcatg tatgtaacct tccatgtttg cttctgataa   3600

atggaaatgt aggttcactg ccacttcatg agatatctct gctcacgctt ccaagttgtt   3660

ctcaatgaca ttagccaaag ttgggtttgc cattcatccc ctaggcatgg taaatcttgt   3720

gttgttccct gctgtcctcc gtattacgtg accggcaaat aaatctcata gcagttaata   3780

taaaacatct ttggaggatg ggagagaaca ggagggaaga tgggaaacaa aatagagaat   3840

tcttaagatt ttgtttaaac caaatgtttc atgtagaatg caaaatgttg gcacgtcaaa   3900

aatatgaatg tgtagacaac tgtagttgtg ctcagtttgt agtgatggga agtgtatttt   3960

actctgatca aataaataat gctggaatac tcaagaattg caaaaaaaaa aaaaaaaa     4018


<210>  2194
<211>  517
<212>  PRT
<213>  Homosapiens

<400>  2194

Met Thr Val Pro Gly Gly Phe Arg Ser Cys Thr Glu Thr Asp Ile Ser 
1               5                   10                  15      


Ser Lys Ile Phe Ile Asn Ser Thr Leu Thr Pro Pro Ala Gly Ser Glu 
            20                  25                  30          


Arg His Tyr Asp Ala Thr Leu Leu Thr Leu Leu Val Val Gly Ser Tyr 
        35                  40                  45              


Ser Leu Cys Ile Ile Pro Leu Leu Ala Thr Phe Thr Gly Lys Lys Thr 
    50                  55                  60                  


Gly Asn Ala Ala Val Ile Lys Tyr Glu Glu Lys Pro Pro Lys Pro Ala 
65                  70                  75                  80  


Phe Gln Asn Gly Ser Ser Gly Ser Phe Tyr Leu Lys Pro Leu Val Ser 
                85                  90                  95      


Arg Ala His Val His Leu Met Lys Thr Pro Pro Lys Gly Pro Ser Arg 
            100                 105                 110         


Lys Asn Leu Phe Thr Ala Leu Asn Ala Val Glu Lys Ser Arg Gln Lys 
        115                 120                 125             


Asn Pro Arg Ser Leu Cys Ile Gln Pro Gln Thr Ala Pro Asp Ala Leu 
    130                 135                 140                 


Pro Pro Glu Lys Thr Leu Glu Leu Thr Gln Tyr Lys Thr Lys Cys Glu 
145                 150                 155                 160 


Asn Gln Ser Gly Phe Ile Leu Gln Leu Lys Gln Leu Leu Ala Cys Gly 
                165                 170                 175     


Asn Thr Lys Phe Glu Ala Leu Thr Val Val Ile Gln His Leu Leu Ser 
            180                 185                 190         


Glu Arg Glu Glu Ala Leu Lys Gln His Lys Thr Leu Ser Gln Glu Leu 
        195                 200                 205             


Val Asn Leu Arg Gly Glu Leu Val Thr Ala Ser Thr Thr Cys Glu Lys 
    210                 215                 220                 


Leu Glu Lys Ala Arg Asn Glu Leu Gln Thr Val Tyr Glu Ala Phe Val 
225                 230                 235                 240 


Gln Gln His Gln Ala Glu Lys Thr Glu Arg Glu Asn Arg Leu Lys Glu 
                245                 250                 255     


Phe Tyr Thr Arg Glu Tyr Glu Lys Leu Arg Asp Thr Tyr Ile Glu Glu 
            260                 265                 270         


Ala Glu Lys Tyr Lys Met Gln Leu Gln Glu Gln Phe Asp Asn Leu Asn 
        275                 280                 285             


Ala Ala His Glu Thr Ser Lys Leu Glu Ile Glu Ala Ser His Ser Glu 
    290                 295                 300                 


Lys Leu Glu Leu Leu Lys Lys Ala Tyr Glu Ala Ser Leu Ser Glu Ile 
305                 310                 315                 320 


Lys Lys Gly His Glu Ile Glu Lys Lys Ser Leu Glu Asp Leu Leu Ser 
                325                 330                 335     


Glu Lys Gln Glu Ser Leu Glu Lys Gln Ile Asn Asp Leu Lys Ser Glu 
            340                 345                 350         


Asn Asp Ala Leu Asn Glu Lys Leu Lys Ser Glu Glu Gln Lys Arg Arg 
        355                 360                 365             


Ala Arg Glu Lys Ala Asn Leu Lys Asn Pro Gln Ile Met Tyr Leu Glu 
    370                 375                 380                 


Gln Glu Leu Glu Ser Leu Lys Ala Val Leu Glu Ile Lys Asn Glu Lys 
385                 390                 395                 400 


Leu His Gln Gln Asp Ile Lys Leu Met Lys Met Glu Lys Leu Val Asp 
                405                 410                 415     


Asn Asn Thr Ala Leu Val Asp Lys Leu Lys Arg Phe Gln Gln Glu Asn 
            420                 425                 430         


Glu Glu Leu Lys Ala Arg Met Asp Lys His Met Ala Ile Ser Arg Gln 
        435                 440                 445             


Leu Ser Thr Glu Gln Ala Val Leu Gln Glu Ser Leu Glu Lys Glu Ser 
    450                 455                 460                 


Lys Val Asn Lys Arg Leu Ser Met Glu Asn Glu Glu Leu Leu Trp Lys 
465                 470                 475                 480 


Leu His Asn Gly Asp Leu Cys Ser Pro Lys Arg Ser Pro Thr Ser Ser 
                485                 490                 495     


Ala Ile Pro Leu Gln Ser Pro Arg Asn Ser Gly Ser Phe Pro Ser Pro 
            500                 505                 510         


Ser Ile Ser Pro Arg 
        515         


<210>  2195
<211>  3738
<212>  DNA
<213>  Homosapiens

<400>  2195
gtggttcaga ggcagcttct agacctgcag gagggagatt gtattcagag gaagagcatc     60

attttggcaa catctgaaag tgaaaacgga agccagaaac acttggccag ccctggggga    120

tttttttctt ctatgcctct ctggtggaat gacatttgct gtgtaggcat ctttcctctg    180

actgtatttc ttggccttga agagtactga gtttaaaaag acagtatgtg acagtccatg    240

gaaattgcct cttctgtgaa atctcgccac ctgctccgaa gacatgttgt tgtctcccaa    300

attctcctta tccaccattc acatacgact gacggccaaa ggattgcttc gaaaccttcg    360

acttccttca gggtttagga gaagcactgt tgttttccac acagttgaaa agagcaggca    420

aaagaatcct cgaagcttat gtatccagcc acagacagct cccgatgcgc tgccccctga    480

gaaaacactt gaattgacgc aatataaaac aaaatgtgaa aaccaaagtg gatttatcct    540

gcagctcaag cagcttcttg cctgtggtaa taccaagttt gaggcattga cagttgtgat    600

tcagcacctg ctgtctgagc gggaggaagc actgaaacaa cacaaaaccc tatctcaaga    660

acttgttaac ctccggggag agctagtcac tgcttcaacc acctgtgaga aattagaaaa    720

agccaggaat gagttacaaa cagtgtatga agcattcgtc cagcagcacc aggctgaaaa    780

aacagaacga gagaatcggc ttaaagagtt ttacaccagg gagtatgaaa agcttcggga    840

cacttacatt gaagaagcag agaagtacaa aatgcaattg caagagcagt ttgacaactt    900

aaatgctgcg catgaaacct ctaagttgga aattgaagct agccactcag agaaacttga    960

attgctaaag aaggcctatg aagcctccct ttcagaaatt aagaaaggcc atgaaataga   1020

aaagaaatcg cttgaagatt tactttctga gaagcaggaa tcgctagaga agcaaatcaa   1080

tgatctgaag agtgaaaatg atgctttaaa tgaaaaattg aaatcagaag aacaaaaaag   1140

aagagcaaga gaaaaagcaa atttgaaaaa tcctcagatc atgtatctag aacaggagtt   1200

agaaagcctg aaagctgtgt tagagatcaa gaatgagaaa ctgcatcaac aggacatcaa   1260

gttaatgaaa atggagaaac tggtggacaa caacacagca ttggttgaca aattgaagcg   1320

tttccagcag gagaatgaag aattgaaagc tcggatggac aagcacatgg caatctcaag   1380

gcagctttcc acggagcagg ctgttctgca agagtcgctg gagaaggagt cgaaagtcaa   1440

caagcgactc tctatggaaa acgaggagct tctgtggaaa ctgcacaatg gggacctgtg   1500

tagccccaag agatccccca catcctccgc catccctttg cagtcaccaa ggaattcggg   1560

ctccttccct agccccagca tttcacccag atgacacctc cccaaagtcc acagactctc   1620

tgaaagcatt ttgatgcagg tctgcaggac tgaccccaag gaggaacgtg ggcacaagag   1680

gtatatcagc acacgtgtga tcaccgtagg gtaactggag cgtcaccacc ggcggaatcg   1740

cagcttctga gactggaact ctggaggaag acttttgcct ccgtccaaaa gattcctcca   1800

aaaaaagatt taaaaaaaga tttcggcatc gacacggacg ttgttgcaca aagcacttaa   1860

agaacgagag catcttgttc attgcctttt tcacctaagc atagggggaa aaactctcag   1920

ggccctatta agatttataa cctttgtaat gttcttcacc acagacacct tcttgtgagt   1980

tttcagtctg actgtggggg tggggggtgt gaatgaaatg gatgtcacag agtgtcatgt   2040

gtctgatgca gcctcctctg ctgtgtatta aatgtcaaaa tctgaatata tctggatatg   2100

tactaatcaa ataataatca atcaatcagc atatacattt cagccaaagc catagaagaa   2160

aaagcaatag ttgcttgaat tatgatcatc taccaccaac tctgctcagc cctgtaacag   2220

ggtagggaga gggtataaca ggaagagctt tgacttgtcc ctgtctatac attctctgta   2280

tcttttgggg gtaacttctt ggcagttttt cagtgttcag ccatgtcagt tgaaactaga   2340

tttttctgta gattttttac ttacccatgt gagcctaaca ctatcctgta attcattttc   2400

tcaggctatg tgtaaatgta gaaccctaat ttttctataa aaaaacaaac taactaactg   2460

tgtaaagaaa gaaaaaggga agtaccaatg ggtttttcca ccttattttt acctttgatc   2520

tacccttgca gatttaacct gtcttcttcc ctcccattat tctcattttc cttttacctt   2580

tctccaccat ccagagccac aaaagcaaac cttctacctc ctacctactt ttctctggga   2640

caaggataaa ggaatatgat tttccagagc cccagagcca gctcatcttc caggtgctga   2700

aaccactttc caaataaact aaagcctgga tttgatatta caaattttgg gaaatcttag   2760

aataaagaac gagaacaagg aagtcattgg ctagtataat taagaaaggt aggattcagt   2820

gcttaccgat gatgcagtac ttgatagaag aaaacagtct gggaggatag cgctcatttt   2880

tcagttaccc tttaaggagt ccctttgtct ttgggaaagt agcagaatgg tccgcttctt   2940

tcccatgagt ggaaaatgtg gcttgtccaa ctctcctcca ggttgcattt cagtttcttt   3000

ccaaaactta ttacctcccc taatcctgag actttggaaa aggtggaagg aagaactgtt   3060

gctttatctc cccctccctg catgtgtcaa cattgtgatg tcagtattta ctaatctaca   3120

ttcagtggct gtacaaataa cagctgtagt aagaagagat tcaggatgct agaggtgaat   3180

atttgggtca tttacatgta cactacatag caagttgata ctcatgttgc atgttctttt   3240

aaattagtga ttttgtgtct taagtcttta acttccaata cttcatcatg tatgtaacct   3300

tccatgtttg cttctgataa atggaaatgt aggttcactg ccacttcatg agatatctct   3360

gctcacgctt ccaagttgtt ctcaatgaca ttagccaaag ttgggtttgc cattcatccc   3420

ctaggcatgg taaatcttgt gttgttccct gctgtcctcc gtattacgtg accggcaaat   3480

aaatctcata gcagttaata taaaacatct ttggaggatg ggagagaaca ggagggaaga   3540

tgggaaacaa aatagagaat tcttaagatt ttgtttaaac caaatgtttc atgtagaatg   3600

caaaatgttg gcacgtcaaa aatatgaatg tgtagacaac tgtagttgtg ctcagtttgt   3660

agtgatggga agtgtatttt actctgatca aataaataat gctggaatac tcaagaattg   3720

caaaaaaaaa aaaaaaaa                                                 3738


<210>  2196
<211>  436
<212>  PRT
<213>  Homosapiens

<400>  2196

Met Leu Leu Ser Pro Lys Phe Ser Leu Ser Thr Ile His Ile Arg Leu 
1               5                   10                  15      


Thr Ala Lys Gly Leu Leu Arg Asn Leu Arg Leu Pro Ser Gly Phe Arg 
            20                  25                  30          


Arg Ser Thr Val Val Phe His Thr Val Glu Lys Ser Arg Gln Lys Asn 
        35                  40                  45              


Pro Arg Ser Leu Cys Ile Gln Pro Gln Thr Ala Pro Asp Ala Leu Pro 
    50                  55                  60                  


Pro Glu Lys Thr Leu Glu Leu Thr Gln Tyr Lys Thr Lys Cys Glu Asn 
65                  70                  75                  80  


Gln Ser Gly Phe Ile Leu Gln Leu Lys Gln Leu Leu Ala Cys Gly Asn 
                85                  90                  95      


Thr Lys Phe Glu Ala Leu Thr Val Val Ile Gln His Leu Leu Ser Glu 
            100                 105                 110         


Arg Glu Glu Ala Leu Lys Gln His Lys Thr Leu Ser Gln Glu Leu Val 
        115                 120                 125             


Asn Leu Arg Gly Glu Leu Val Thr Ala Ser Thr Thr Cys Glu Lys Leu 
    130                 135                 140                 


Glu Lys Ala Arg Asn Glu Leu Gln Thr Val Tyr Glu Ala Phe Val Gln 
145                 150                 155                 160 


Gln His Gln Ala Glu Lys Thr Glu Arg Glu Asn Arg Leu Lys Glu Phe 
                165                 170                 175     


Tyr Thr Arg Glu Tyr Glu Lys Leu Arg Asp Thr Tyr Ile Glu Glu Ala 
            180                 185                 190         


Glu Lys Tyr Lys Met Gln Leu Gln Glu Gln Phe Asp Asn Leu Asn Ala 
        195                 200                 205             


Ala His Glu Thr Ser Lys Leu Glu Ile Glu Ala Ser His Ser Glu Lys 
    210                 215                 220                 


Leu Glu Leu Leu Lys Lys Ala Tyr Glu Ala Ser Leu Ser Glu Ile Lys 
225                 230                 235                 240 


Lys Gly His Glu Ile Glu Lys Lys Ser Leu Glu Asp Leu Leu Ser Glu 
                245                 250                 255     


Lys Gln Glu Ser Leu Glu Lys Gln Ile Asn Asp Leu Lys Ser Glu Asn 
            260                 265                 270         


Asp Ala Leu Asn Glu Lys Leu Lys Ser Glu Glu Gln Lys Arg Arg Ala 
        275                 280                 285             


Arg Glu Lys Ala Asn Leu Lys Asn Pro Gln Ile Met Tyr Leu Glu Gln 
    290                 295                 300                 


Glu Leu Glu Ser Leu Lys Ala Val Leu Glu Ile Lys Asn Glu Lys Leu 
305                 310                 315                 320 


His Gln Gln Asp Ile Lys Leu Met Lys Met Glu Lys Leu Val Asp Asn 
                325                 330                 335     


Asn Thr Ala Leu Val Asp Lys Leu Lys Arg Phe Gln Gln Glu Asn Glu 
            340                 345                 350         


Glu Leu Lys Ala Arg Met Asp Lys His Met Ala Ile Ser Arg Gln Leu 
        355                 360                 365             


Ser Thr Glu Gln Ala Val Leu Gln Glu Ser Leu Glu Lys Glu Ser Lys 
    370                 375                 380                 


Val Asn Lys Arg Leu Ser Met Glu Asn Glu Glu Leu Leu Trp Lys Leu 
385                 390                 395                 400 


His Asn Gly Asp Leu Cys Ser Pro Lys Arg Ser Pro Thr Ser Ser Ala 
                405                 410                 415     


Ile Pro Leu Gln Ser Pro Arg Asn Ser Gly Ser Phe Pro Ser Pro Ser 
            420                 425                 430         


Ile Ser Pro Arg 
        435     


<210>  2197
<211>  1438
<212>  DNA
<213>  Homosapiens

<400>  2197
agcacttcct catagacctt ggatgtggga ggattgcatt cagtctagtt cctggttgcc     60

ggctgaaata acctgaattc aagccaggaa gaagcagcaa tctgtcttct ggattaaaac    120

tgaagatcaa cctactttca acttactaag aaaggggatc atggacattg aagcatatct    180

tgaaagaatt ggctataaga agtctaggaa caaattggac ttggaaacat taactgacat    240

tcttcaacac cagatccgag ctgttccctt tgagaacctt aacatccatt gtggggatgc    300

catggactta ggcttagagg ccatttttga tcaagttgtg agaagaaatc ggggtggatg    360

gtgtctccag gtcaatcatc ttctgtactg ggctctgacc actattggtt ttgagaccac    420

gatgttggga gggtatgttt acagcactcc agccaaaaaa tacagcactg gcatgattca    480

ccttctcctg caggtgacca ttgatggcag gaactacatt gtcgatgctg ggtttggacg    540

ctcataccag atgtggcagc ctctggagtt aatttctggg aaggatcagc ctcaggtgcc    600

ttgtgtcttc cgtttgacgg aagagaatgg attctggtat ctagaccaaa tcagaaggga    660

acagtacatt ccaaatgaag aatttcttca ttctgatctc ctagaagaca gcaaataccg    720

aaaaatctac tcctttactc ttaagcctcg aacaattgaa gattttgagt ctatgaatac    780

atacctgcag acatctccat catctgtgtt tactagtaaa tcattttgtt ccttgcagac    840

cccagatggg gttcactgtt tggtgggctt caccctcacc cataggagat tcaattataa    900

ggacaataca gatctaatag agttcaagac tctgagtgag gaagaaatag aaaaagtgct    960

gaaaaatata tttaatattt ccttgcagag aaagcttgtg cccaaacatg gtgatagatt   1020

ttttactatt tagaataagg agtaaaacaa tcttgtctat ttgtcatcca gctcaccagt   1080

tatcaactga cgacctatca tgtatcttct gtacccttac cttattttga agaaaatcct   1140

agacatcaaa tcatttcacc tataaaaatg tcatcatata taattaaaca gctttttaaa   1200

gaaacataac cacaaacctt ttcaaataat aataataata ataataaaaa atgtatttta   1260

aagatggcct gtggttatct tggaaattgg tgatttatgc tagaaagctt ttaatgttgg   1320

tttattgttg aattcctaga aaagttttat tggtagatga gtaaataaaa tattgtaaaa   1380

aaacttattg tctataaagt atattaaaac attgttggct aataaaaaaa aaaaaaaa     1438


<210>  2198
<211>  290
<212>  PRT
<213>  Homosapiens

<400>  2198

Met Asp Ile Glu Ala Tyr Leu Glu Arg Ile Gly Tyr Lys Lys Ser Arg 
1               5                   10                  15      


Asn Lys Leu Asp Leu Glu Thr Leu Thr Asp Ile Leu Gln His Gln Ile 
            20                  25                  30          


Arg Ala Val Pro Phe Glu Asn Leu Asn Ile His Cys Gly Asp Ala Met 
        35                  40                  45              


Asp Leu Gly Leu Glu Ala Ile Phe Asp Gln Val Val Arg Arg Asn Arg 
    50                  55                  60                  


Gly Gly Trp Cys Leu Gln Val Asn His Leu Leu Tyr Trp Ala Leu Thr 
65                  70                  75                  80  


Thr Ile Gly Phe Glu Thr Thr Met Leu Gly Gly Tyr Val Tyr Ser Thr 
                85                  90                  95      


Pro Ala Lys Lys Tyr Ser Thr Gly Met Ile His Leu Leu Leu Gln Val 
            100                 105                 110         


Thr Ile Asp Gly Arg Asn Tyr Ile Val Asp Ala Gly Phe Gly Arg Ser 
        115                 120                 125             


Tyr Gln Met Trp Gln Pro Leu Glu Leu Ile Ser Gly Lys Asp Gln Pro 
    130                 135                 140                 


Gln Val Pro Cys Val Phe Arg Leu Thr Glu Glu Asn Gly Phe Trp Tyr 
145                 150                 155                 160 


Leu Asp Gln Ile Arg Arg Glu Gln Tyr Ile Pro Asn Glu Glu Phe Leu 
                165                 170                 175     


His Ser Asp Leu Leu Glu Asp Ser Lys Tyr Arg Lys Ile Tyr Ser Phe 
            180                 185                 190         


Thr Leu Lys Pro Arg Thr Ile Glu Asp Phe Glu Ser Met Asn Thr Tyr 
        195                 200                 205             


Leu Gln Thr Ser Pro Ser Ser Val Phe Thr Ser Lys Ser Phe Cys Ser 
    210                 215                 220                 


Leu Gln Thr Pro Asp Gly Val His Cys Leu Val Gly Phe Thr Leu Thr 
225                 230                 235                 240 


His Arg Arg Phe Asn Tyr Lys Asp Asn Thr Asp Leu Ile Glu Phe Lys 
                245                 250                 255     


Thr Leu Ser Glu Glu Glu Ile Glu Lys Val Leu Lys Asn Ile Phe Asn 
            260                 265                 270         


Ile Ser Leu Gln Arg Lys Leu Val Pro Lys His Gly Asp Arg Phe Phe 
        275                 280                 285             


Thr Ile 
    290 


<210>  2199
<211>  1276
<212>  DNA
<213>  Homosapiens

<400>  2199
tgagatcact tcccttgcac agtttggaag ggagagcact ttattacaga ccttggaagc     60

aagaggattg cattcagcct agttcctggt tgctggccaa agggatcatg gacattgaag    120

catattttga aagaattggc tataagaact ctaggaacaa attggacttg gaaacattaa    180

ctgacattct tgagcaccag atccgggctg ttccctttga gaaccttaac atgcattgtg    240

ggcaagccat ggagttgggc ttagaggcta tttttgatca cattgtaaga agaaaccggg    300

gtgggtggtg tctccaggtc aatcaacttc tgtactgggc tctgaccaca atcggttttc    360

agaccacaat gttaggaggg tatttttaca tccctccagt taacaaatac agcactggca    420

tggttcacct tctcctgcag gtgaccattg acggcaggaa ttacattgtc gatgctgggt    480

ctggaagctc ctcccagatg tggcagcctc tagaattaat ttctgggaag gatcagcctc    540

aggtgccttg cattttctgc ttgacagaag agagaggaat ctggtacctg gaccaaatca    600

ggagagagca gtatattaca aacaaagaat ttcttaattc tcatctcctg ccaaagaaga    660

aacaccaaaa aatatactta tttacgcttg aacctcgaac aattgaagat tttgagtcta    720

tgaatacata cctgcagacg tctccaacat cttcatttat aaccacatca ttttgttcct    780

tgcagacccc agaaggggtt tactgtttgg tgggcttcat cctcacctat agaaaattca    840

attataaaga caatacagat ctggtcgagt ttaaaactct cactgaggaa gaggttgaag    900

aagtgctgaa aaatatattt aagatttcct tggggagaaa tctcgtgccc aaacctggtg    960

atggatccct tactatttag aataaggaac aaaataaacc cttgtgtatg tatcacccaa   1020

ctcactaatt atcaacttat gtgctatcag atatcctctc taccctcacg ttattttgaa   1080

gaaaatccta aacatcaaat actttcatcc ataaaaatgt cagcatttat taaaaaacaa   1140

taacttttta aagaaacata aggacacatt ttcaaattaa taaaaataaa ggcattttaa   1200

ggatggcctg tgattatctt gggaagcaga gtgattcatg ctagaaaaca tttaatattg   1260

atttattgtt gaattc                                                   1276


<210>  2200
<211>  290
<212>  PRT
<213>  Homosapiens

<400>  2200

Met Asp Ile Glu Ala Tyr Phe Glu Arg Ile Gly Tyr Lys Asn Ser Arg 
1               5                   10                  15      


Asn Lys Leu Asp Leu Glu Thr Leu Thr Asp Ile Leu Glu His Gln Ile 
            20                  25                  30          


Arg Ala Val Pro Phe Glu Asn Leu Asn Met His Cys Gly Gln Ala Met 
        35                  40                  45              


Glu Leu Gly Leu Glu Ala Ile Phe Asp His Ile Val Arg Arg Asn Arg 
    50                  55                  60                  


Gly Gly Trp Cys Leu Gln Val Asn Gln Leu Leu Tyr Trp Ala Leu Thr 
65                  70                  75                  80  


Thr Ile Gly Phe Gln Thr Thr Met Leu Gly Gly Tyr Phe Tyr Ile Pro 
                85                  90                  95      


Pro Val Asn Lys Tyr Ser Thr Gly Met Val His Leu Leu Leu Gln Val 
            100                 105                 110         


Thr Ile Asp Gly Arg Asn Tyr Ile Val Asp Ala Gly Ser Gly Ser Ser 
        115                 120                 125             


Ser Gln Met Trp Gln Pro Leu Glu Leu Ile Ser Gly Lys Asp Gln Pro 
    130                 135                 140                 


Gln Val Pro Cys Ile Phe Cys Leu Thr Glu Glu Arg Gly Ile Trp Tyr 
145                 150                 155                 160 


Leu Asp Gln Ile Arg Arg Glu Gln Tyr Ile Thr Asn Lys Glu Phe Leu 
                165                 170                 175     


Asn Ser His Leu Leu Pro Lys Lys Lys His Gln Lys Ile Tyr Leu Phe 
            180                 185                 190         


Thr Leu Glu Pro Arg Thr Ile Glu Asp Phe Glu Ser Met Asn Thr Tyr 
        195                 200                 205             


Leu Gln Thr Ser Pro Thr Ser Ser Phe Ile Thr Thr Ser Phe Cys Ser 
    210                 215                 220                 


Leu Gln Thr Pro Glu Gly Val Tyr Cys Leu Val Gly Phe Ile Leu Thr 
225                 230                 235                 240 


Tyr Arg Lys Phe Asn Tyr Lys Asp Asn Thr Asp Leu Val Glu Phe Lys 
                245                 250                 255     


Thr Leu Thr Glu Glu Glu Val Glu Glu Val Leu Lys Asn Ile Phe Lys 
            260                 265                 270         


Ile Ser Leu Gly Arg Asn Leu Val Pro Lys Pro Gly Asp Gly Ser Leu 
        275                 280                 285             


Thr Ile 
    290 


<210>  2201
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  2201
aacaaagagc acgcggcgct ggccgccggc actcgcgccc tgaggctgcg gccccggagc     60

gcccggcggc ggtttcggcg cgcggccggg ctggcgatgg aagatggaag gaaggagcgc    120

agcggcagag acatttgttt gggtgaacaa tgcatctgca cattcccaga gtgttgccaa    180

ggccaaatat gaatttttat ttggcagatc tgaagggaaa gctccagata ctagtgatca    240

tggaggaagc actttactcc caccaaatgt cacaaatgaa tttccagaat atgggaccat    300

ggaggaaggt ggagaaggcc taagggcttc tctggaattt gatggtgagg ctctgccatg    360

ccacccacaa gagcagcagg gtgtccagcc tcttactggc tgccactctg ggctcgacag    420

tgttacagaa ggaccaaaag atgtcagaga ggccccctct caaagtcatc tcaaggaaca    480

aagtttacag cccattgact ctttgatttc agctctgaaa gccacagaag ccagaatcat    540

ttccggaaca ttacaggcta caaaggtact ggaccaagat gctgtttcta gtttttcagt    600

tcagcaggtg gaaaaagagc tggacactgc cagtcgtaaa acacagagag tcaacaaact    660

gctccctgct ggccaaaaaa atttaccaga aatacctctt tcagctgaag taacaacgga    720

ggaaagtttt tatttgagca tccagaaaga tctcaccgcg ctgttaactg gagacactca    780

ggcagagatt tcccagataa tgaataatgg gaggaaaggg gctgtctgtg tgcaggagcc    840

atcttgtcct ttggcctccc tcgggagctc agcagtgacc tgccactctg caggcagtgt    900

tggtttcttg aaagagcaga ggtctgctct tgggagagag cacccagggg gatgtgatcg    960

aagcagctcc atgggacgcc caggccgggt caaacatgtg gaatttcaag gagtggaaat   1020

actgtggaca ggaggagaca agagagagac ccagcatcct atagattttg agacatcact   1080

gcaaagaaca gcctctcctg acagcaaaga gtcttccaaa gtgccacgcc atctcatctc   1140

atcagctggt ttgtgtaatt caagtagttt aactgagaat gtttgggatg aatcctggaa   1200

agctccttca gagaggcctg gcactagctc ggggacattt tcccctgtgc gtcttgatga   1260

gagtggagag gatgaagtct tcctacagga aaacaaacag catcttgaga agacacctaa   1320

accagagaga gacagggaaa ggatcagcga acaagaggag cacgttaagg gggaagatga   1380

agacatcctt gggcctggat atacggagga ctccaccgac gtgtacagct cccagtttga   1440

aaccattttg gacaacactt ctttatacta cagtgcagag tccctggaga cattatactc   1500

agagcctgat agctatttta gctttgaaat gcccctcact ccaatgatac aacagcgcat   1560

taaagaaggt ggtcagttct tggagaggac atcaggggga ggacatcagg atatcctgag   1620

tgtgtctgca gatggtggca tcgtgatggg ctattctagt ggcgtcacca atgggctgaa   1680

tgatgccagc gactccatct acacgaaagg caccccggag attgctttct ggggaagcaa   1740

tgctggggtg aaaacaacac ggctagaagc tcattctgaa atggggagca ctgaaatttt   1800

ggaaaaggag accccagaaa atctcagtaa tggtaccagc agcaatgtgg aagcagccaa   1860

aaggttggcc aaacgccttt atcagctgga cagattcaaa agatcagatg ttgcaaaaca   1920

ccttggcaag aacaacgaat ttagcaaact agttgcagaa gaatatctga agttttttga   1980

ttttacagga atgacgctgg atcagtcact caggtatttc tttaaagcat tctctcttgt   2040

gggagaaact caagaacgag agagagtttt aatacacttc tccaatagat atttttattg   2100

taacccagat accattgctt cacaagatgg agtccattgc cttacctgtg caataatgct   2160

tcttaatacc gatctacatg gccaaatatt ggaaagaaga tgacctgtca ggagttcatt   2220

gcaaatctgc aaggggtaaa tgagggtgtt gatttctcca aggatctgct gaaagctctg   2280

tacaactcaa tcaagaatga gaagcttgaa tgggcagtag atgatgaaga gaaaaaaaag   2340

tctccctcag aaagtactga ggagaaagct aacggaacac atccaaagac catcagtcgt   2400

attggaagta ctactaaccc atttttggac attcctcatg atccaaatgc tgctgtgtac   2460

aaaagtggat tcttggctcg gaaaattcat gcagatatgg atggaaagaa gactccaaga   2520

ggaaaacgag gatggaaaac cttttatgct gtactgaagg gaacagttct ttacttgcaa   2580

aaggatgaat acaagccaga aaaggccttg tctgaagagg acttgaaaaa cgctgtgagt   2640

gtgcaccacg cattggcatc caaggccacg gactatgaga agaaaccaaa cgtgtttaaa   2700

cttaaaactg ccgactggag ggtcttgctt tttcaaactc agagcccaga ggaaatgcaa   2760

gggtggataa acaaaatcaa ttgtgtggca gctgtatttt ctgcaccacc atttccagca   2820

gcaatcggct ctcagaagaa gtttagccgc ccacttctgc ctgccactac aacaaaactg   2880

tctcaggagg agcaactgaa gtcacatgaa agtaagctga agcagatcac caccgagctg   2940

gccgagcacc gctcatatcc ccccgacaag aaggtcaaag ccaaggacgt cgatgagtac   3000

aaactgaaag accactatct ggagtttgag aaaacccgct atgaaatgta tgtcagcatt   3060

ctcaaggaag gaggcaaaga gctactgagt aacgatgaaa gcgaggctgc aggactgaag   3120

aagtcgcact cgagtccttc gctgaacccg gatacttctc caatcactgc caaagtcaag   3180

cgtaacgtgt cagagaggaa ggatcaccga cctgaaacac caagcattaa gcaaaaagtt   3240

acttagagtc catctgcggc caggaagtgc tggtcatgga gcaaaatagg gtttttcaag   3300

atctttctgg taatccgtga atatatttaa aaaaaaaaag tctgtgacaa aacggtgcat   3360

tagtaatttt ttctattgta tatttttgtt agtttctgta cagattgtct ttgctcttga   3420

tttcttttgc tttgatgatt tttgcaactt gatagctaat gcaccttttc tgtgaggagg   3480

aggggatcgt gatttcagaa tgaattatgt atcccttctc ttttggtttt ctcttgtttg   3540

cagtctgctc agttgtttta tgtattctca tatcaactgt taaacttttt tttaaggtta   3600

aagaatttaa tccattgtga aacacttaac tggacaaact gtagttttag taaattctag   3660

ctggagttaa tatacgcctt tatatgtgaa atcttgccca gtcacagagg tagaattgag   3720

cactcacaga tgctccagta agaatcacag tgctgggaat ctagttgctc caatatgagg   3780

cagcttcatg tgcagcttag cacttgttgt tgagatcgga ccctgctgga agcagggaaa   3840

agaagcgtga agatcgtagg attgagaact tagggaagca cattagcttg cttgaagtgc   3900

tgattccatt tcagccaagc aagggaaaga ggaagtggag tcattttgcc tttgaaggct   3960

gaggaaagat tgatacccag ttaattttgt ttgctaaagg atgggggcaa taatcggccc   4020

ttgaggagct gcagcagtag gcatgtgctc agtctgcagg aattgttacc tcactcccac   4080

agggtctaga ctagaaatcc atcatctcta tcgttgatat ccttccatcc aggaatagat   4140

ttttcttact ctacatatgt gtgtgtgcgt gcgtgtgtgt gcgtgtgtgg gcatggggtt   4200

gtgtcctggt tgtgatattg aggtcttcct tcctaacaaa ttaatactaa aatgaaacag   4260

cttttcttgt gtccttaaga caaaataagg aaggaaaacg tagctgcagt tgtccacgat   4320

ggatattggt tctttaaaat atatctgaaa gtagtagtca gaatgaatta tggttggaaa   4380

actgaggaat cttctggttg caggtgcaaa gtgactttgt ttattcttgt ctcagtctcc   4440

ttgatagcca cttcactctg ctactactca actttctcct aaaaatactt catctatttt   4500

cagtcctttc tttctgtcta ctcaaaatgg ttctattaac tttgcagtca tgagcttgtt   4560

ccagttacag tccctttgaa gttcagggtg ataaacagaa tattcttctg tagaggaaga   4620

gaaaggagtg aaagtttagc ccactgagac ctagagcttt gtgatttcct aaccttgaaa   4680

ctctgtaatc cctaaagtta aaatctccgc aagtggcaca acttcagaac taatagtatc   4740

actttgattt ttctttttcc tcccttagaa agtttctcta gttctatagt ttatttgttg   4800

aaggtactat gaccaaagaa tcagctgctc tacaggaata gcatggttcc agtgaattag   4860

agaaaacctg ctgtaaagcc atggtagtgt ctaagtggta tgttattatg atgtactagc   4920

atttatttac agaattattt attaacgttt acttccttcc cctctgtaaa tgtccatgac   4980

tattgcccag agaaggctta cccctctcta gggttgcagt tgctttcttt gtaataagta   5040

ttttgccaca cctgtaaaaa aaaaaacctc acttttaact ctctgccttg tttgggtaaa   5100

ggcagtaact aagtttatgt ttcagaactg caaaacaaac aggatagtta ccaatatggc   5160

ccatgtgtca gattgatttt tgtagcctct cactgaatcc aacatatcca caagcaagtt   5220

atctgtcttt ctacctgata atctaaatta tcaggatatt tgttttctgc ctaaatgttt   5280

atactaagcc gaggggagag aggtacctag accatgtcat ctacgagctt cagtaactaa   5340

agaaaaagga acttccctga gtggcttgaa tgtgtttgcc cacagtctat atctatgtat   5400

atagaatgtc tgtatgtatt ttacttattt aatatacatt gaatggtacc ttgctacagt   5460

atttctgaca tttagagtag tgttgaaata ctcggctagc atcagcacca ctatagcact   5520

gtccgtgtca tatgagtcac taatattaac tccagggact tctggatagg ctaatagatc   5580

attggatacg aagggctctt ttgaagcttc agtataccat gtttgcatag tttatcttta   5640

aaaacaactt taaaggttct tttgtgagcc aggatctcag actgccgtag catgatgctg   5700

tccatcttta gcgcatgggc tgagaacacc tcttccctga ggcttctgaa ggttgctgtc   5760

tgtcatgagt gcatgaagga ggccaagagt ttatgctatg ggaggaacca gtcactgatt   5820

tgcctagatt ctgagagtct ggcccatagc caaccacatt ttcctttggg ataatttatt   5880

tcctgtggca tctagccaga agaaattgag gatgtttcct ttcacagctg ctccaagcct   5940

gttgcccaat tcacggtaca agggagcacc ccttcccttt cctctgaagg tacgccaccc   6000

acctccgtcg cccacctcag cgcccaggag ccttgggact tccttccata tgataaatca   6060

ttcttcttca cgtcaataca cttcatatta atttctagta cagaaaatct tgacagctat   6120

cagaatgcct tggtcatagt gttgttgcaa aattgaccat acaggtggcc catgtataaa   6180

atctgaattt taggggtttg tccccacctc gcatgctggc ttttacaggg aggtgtctgg   6240

gattcctcat tagcaatcaa aacttaatta ctgggatgca gagtccttac tttatcgcca   6300

gcccgtaggc atttctgaag tgcacttttt tgaaacatca ttttgctaac tctcagcagt   6360

gtctaattaa actgagcaat acttttgtga attttaatta atctcagcaa aaccatgatg   6420

ggagagagtc ctctgatgga aatgtagtcc ctggattatg tgtaaccttt ttattgctct   6480

tagatgcaga ggatagaaag cattttttgg tgcagtggtc ttgtggcaaa cacaagaccc   6540

tctatgcgtc tccaactgtt atcctaatct agaaaatgag gactggcccc tgggcaaaag   6600

tgacatgagg aatttactct ggaagaggaa aatctgggtg gctttccaag gctaagatag   6660

gtttgtattt caccctgtgg ccaagctaca gaacttctga gattgtggaa gaatttttgc   6720

aaccagcagg gaaagaggcc tcttactgcc taaacacaaa gttacactga gcttttctac   6780

tgtcctttgc ctattgctcc ctctatcatg taaagatctg ggaaggatga gaggcagggc   6840

ctgcttgtca tgagctgcac tcttttcttt ttaactaatc attgacaatt ggaagaaaat   6900

tgacgttaaa gaagtttctc cattgtctta ctaacaaaac cttttgggtt tcattaattg   6960

tccttgaaat tgagttcctt tggcattttt ccttgcagtc atcagttaag catgttgcat   7020

cctgaattca cagaagttta gctttgcagg tttgaatctc tgtaatttaa ctcccgtgga   7080

cttggtcgag ttttcagcag gttgggagcc acctctcttc atttcagcag tgagtcatcc   7140

cttgactttt caaatgacag aattttttcc aattgtaaaa ttagcactgt aaaacaaaga   7200

accaaagtgg catcctaaga gttgttaaac ctgaagtcta gtttatgagg aattgtccaa   7260

gttggagttt aaatagtatc tgcttttgtc tcaaagcatc taagttattc tgacagaaaa   7320

tggtaagtca gctttgcagg cagatgcgcc tctgggcctc ctaccttgct ccacagcttt   7380

ctggccatct tgtctcccag gccatgccac tgctctgcca catgtcagca aatttctttc   7440

caccagtctt atagcatctt acatgatcaa atcatcacag aataaccccg tgatagatta   7500

ttgatagcaa tagagagggg ctttgtcact gatttttctc tcagattcct tttccatctc   7560

tcatccataa aggaaggact gaaatccaaa ggcattctcc ttttgtacct acagtatcca   7620

gaacccacgt gggcagcctt ctgcttatga caataattgg cccattgcat gcagagagaa   7680

tgtcttcata gagagaatgt cattaaatac ttgaatctgc atgacagttt gacttgaatg   7740

caacagcagg aaaattttgc aagttacata attgtatata cagtaggttt tcttaagtct   7800

cttcggttca tcctttgtaa tttgtgtgtg tatctgtagt attgcaggct tttggagact   7860

attcttacag gcagtatgtc agtcatcaaa gaaaatgctg tcacctgcca ttgttgtatt   7920

tgtgggtatt tatagttgta tgtatgtaaa tgcatcagtg tgtagattgc atatcagtgt   7980

atggtacatg tacatcaaaa ttatttttgt ccttaatcag tgtgatatga aaagcaagta   8040

caacctcata ggactgatta tataatgaag ttgttgagag tatatatagt ggtattgttt   8100

tattaaactt aaactcaaat aatattttga ttaaaatttt taataagact ttatgctaga   8160

aaattctttg agctttgaat caccagggca aa                                 8192


<210>  2202
<211>  699
<212>  PRT
<213>  Homosapiens

<400>  2202

Met Glu Gly Arg Ser Ala Ala Ala Glu Thr Phe Val Trp Val Asn Asn 
1               5                   10                  15      


Ala Ser Ala His Ser Gln Ser Val Ala Lys Ala Lys Tyr Glu Phe Leu 
            20                  25                  30          


Phe Gly Arg Ser Glu Gly Lys Ala Pro Asp Thr Ser Asp His Gly Gly 
        35                  40                  45              


Ser Thr Leu Leu Pro Pro Asn Val Thr Asn Glu Phe Pro Glu Tyr Gly 
    50                  55                  60                  


Thr Met Glu Glu Gly Gly Glu Gly Leu Arg Ala Ser Leu Glu Phe Asp 
65                  70                  75                  80  


Gly Glu Ala Leu Pro Cys His Pro Gln Glu Gln Gln Gly Val Gln Pro 
                85                  90                  95      


Leu Thr Gly Cys His Ser Gly Leu Asp Ser Val Thr Glu Gly Pro Lys 
            100                 105                 110         


Asp Val Arg Glu Ala Pro Ser Gln Ser His Leu Lys Glu Gln Ser Leu 
        115                 120                 125             


Gln Pro Ile Asp Ser Leu Ile Ser Ala Leu Lys Ala Thr Glu Ala Arg 
    130                 135                 140                 


Ile Ile Ser Gly Thr Leu Gln Ala Thr Lys Val Leu Asp Gln Asp Ala 
145                 150                 155                 160 


Val Ser Ser Phe Ser Val Gln Gln Val Glu Lys Glu Leu Asp Thr Ala 
                165                 170                 175     


Ser Arg Lys Thr Gln Arg Val Asn Lys Leu Leu Pro Ala Gly Gln Lys 
            180                 185                 190         


Asn Leu Pro Glu Ile Pro Leu Ser Ala Glu Val Thr Thr Glu Glu Ser 
        195                 200                 205             


Phe Tyr Leu Ser Ile Gln Lys Asp Leu Thr Ala Leu Leu Thr Gly Asp 
    210                 215                 220                 


Thr Gln Ala Glu Ile Ser Gln Ile Met Asn Asn Gly Arg Lys Gly Ala 
225                 230                 235                 240 


Val Cys Val Gln Glu Pro Ser Cys Pro Leu Ala Ser Leu Gly Ser Ser 
                245                 250                 255     


Ala Val Thr Cys His Ser Ala Gly Ser Val Gly Phe Leu Lys Glu Gln 
            260                 265                 270         


Arg Ser Ala Leu Gly Arg Glu His Pro Gly Gly Cys Asp Arg Ser Ser 
        275                 280                 285             


Ser Met Gly Arg Pro Gly Arg Val Lys His Val Glu Phe Gln Gly Val 
    290                 295                 300                 


Glu Ile Leu Trp Thr Gly Gly Asp Lys Arg Glu Thr Gln His Pro Ile 
305                 310                 315                 320 


Asp Phe Glu Thr Ser Leu Gln Arg Thr Ala Ser Pro Asp Ser Lys Glu 
                325                 330                 335     


Ser Ser Lys Val Pro Arg His Leu Ile Ser Ser Ala Gly Leu Cys Asn 
            340                 345                 350         


Ser Ser Ser Leu Thr Glu Asn Val Trp Asp Glu Ser Trp Lys Ala Pro 
        355                 360                 365             


Ser Glu Arg Pro Gly Thr Ser Ser Gly Thr Phe Ser Pro Val Arg Leu 
    370                 375                 380                 


Asp Glu Ser Gly Glu Asp Glu Val Phe Leu Gln Glu Asn Lys Gln His 
385                 390                 395                 400 


Leu Glu Lys Thr Pro Lys Pro Glu Arg Asp Arg Glu Arg Ile Ser Glu 
                405                 410                 415     


Gln Glu Glu His Val Lys Gly Glu Asp Glu Asp Ile Leu Gly Pro Gly 
            420                 425                 430         


Tyr Thr Glu Asp Ser Thr Asp Val Tyr Ser Ser Gln Phe Glu Thr Ile 
        435                 440                 445             


Leu Asp Asn Thr Ser Leu Tyr Tyr Ser Ala Glu Ser Leu Glu Thr Leu 
    450                 455                 460                 


Tyr Ser Glu Pro Asp Ser Tyr Phe Ser Phe Glu Met Pro Leu Thr Pro 
465                 470                 475                 480 


Met Ile Gln Gln Arg Ile Lys Glu Gly Gly Gln Phe Leu Glu Arg Thr 
                485                 490                 495     


Ser Gly Gly Gly His Gln Asp Ile Leu Ser Val Ser Ala Asp Gly Gly 
            500                 505                 510         


Ile Val Met Gly Tyr Ser Ser Gly Val Thr Asn Gly Leu Asn Asp Ala 
        515                 520                 525             


Ser Asp Ser Ile Tyr Thr Lys Gly Thr Pro Glu Ile Ala Phe Trp Gly 
    530                 535                 540                 


Ser Asn Ala Gly Val Lys Thr Thr Arg Leu Glu Ala His Ser Glu Met 
545                 550                 555                 560 


Gly Ser Thr Glu Ile Leu Glu Lys Glu Thr Pro Glu Asn Leu Ser Asn 
                565                 570                 575     


Gly Thr Ser Ser Asn Val Glu Ala Ala Lys Arg Leu Ala Lys Arg Leu 
            580                 585                 590         


Tyr Gln Leu Asp Arg Phe Lys Arg Ser Asp Val Ala Lys His Leu Gly 
        595                 600                 605             


Lys Asn Asn Glu Phe Ser Lys Leu Val Ala Glu Glu Tyr Leu Lys Phe 
    610                 615                 620                 


Phe Asp Phe Thr Gly Met Thr Leu Asp Gln Ser Leu Arg Tyr Phe Phe 
625                 630                 635                 640 


Lys Ala Phe Ser Leu Val Gly Glu Thr Gln Glu Arg Glu Arg Val Leu 
                645                 650                 655     


Ile His Phe Ser Asn Arg Tyr Phe Tyr Cys Asn Pro Asp Thr Ile Ala 
            660                 665                 670         


Ser Gln Asp Gly Val His Cys Leu Thr Cys Ala Ile Met Leu Leu Asn 
        675                 680                 685             


Thr Asp Leu His Gly Gln Ile Leu Glu Arg Arg 
    690                 695                 


<210>  2203
<211>  6822
<212>  DNA
<213>  Homosapiens

<400>  2203
aggctcggca gtcactgaac ttgggagctg aagaatactg gacggggctt cggagaggaa     60

ggatggtcca ggcgcacccc aggggttgcg atgggctctt cttggtgtct gtatggttgc    120

tgcaatgctg gggtgaaaac aacacggcta gaagctcatt ctgaaatggg gagcactgaa    180

attttggaaa aggagacccc agaaaatctc agtaatggta ccagcagcaa tgtggaagca    240

gccaaaaggt tggccaaacg cctttatcag ctggacagat tcaaaagatc agatgttgca    300

aaacaccttg gcaagaacaa cgaatttagc aaactagttg cagaagaata tctgaagttt    360

tttgatttta caggaatgac gctggatcag tcactcaggt atttctttaa agcattctct    420

cttgtgggag aaactcaaga acgagagaga gttttaatac acttctccaa tagatatttt    480

tattgtaacc cagataccat tgcttcacaa gatggagtcc attgccttac ctgtgcaata    540

atgcttctta ataccgatct acatggccac aatattggaa agaagatgac ctgtcaggag    600

ttcattgcaa atctgcaagg ggtaaatgag ggtgttgatt tctccaagga tctgctgaaa    660

gctctgtaca actcaatcaa gaatgagaag cttgaatggg cagtagatga tgaagagaaa    720

aaaaagtctc cctcagaaag tactgaggag aaagctaacg gaacacatcc aaagaccatc    780

agtcgtattg gaagtactac taacccattt ttggacattc ctcatgatcc aaatgctgct    840

gtgtacaaaa gtggattctt ggctcggaaa attcatgcag atatggatgg aaagaagact    900

ccaagaggaa aacgaggatg gaaaaccttt tatgctgtac tgaagggaac agttctttac    960

ttgcaaaagg atgaatacaa gccagaaaag gccttgtctg aagaggactt gaaaaacgct   1020

gtgagtgtgc accacgcatt ggcatccaag gccacggact atgagaagaa accaaacgtg   1080

tttaaactta aaactgccga ctggagggtc ttgctttttc aaactcagag cccagaggaa   1140

atgcaagggt ggataaacaa aatcaattgt gtggcagctg tattttctgc accaccattt   1200

ccagcagcaa tcggctctca gaagaagttt agccgcccac ttctgcctgc cactacaaca   1260

aaactgtctc aggaggagca actgaagtca catgaaagta agctgaagca gatcaccacc   1320

gagctggccg agcaccgctc atatcccccc gacaagaagg tcaaagccaa ggacgtcgat   1380

gagtacaaac tgaaagacca ctatctggag tttgagaaaa cccgctatga aatgtatgtc   1440

agcattctca aggaaggagg caaagagcta ctgagtaacg atgaaagcga ggctgcagga   1500

ctgaagaagt cgcactcgag tccttcgctg aacccggata cttctccaat cactgccaaa   1560

gtcaagcgta acgtgtcaga gaggaaggat caccgacctg aaacaccaag cattaagcaa   1620

aaagttactt agagtccatc tgcggccagg aagtgctggt catggagcaa aatagggttt   1680

ttcaagatct ttctggtaat ccgtgaatat atttaaaaaa aaaaagtctg tgacaaaacg   1740

gtgcattagt aattttttct attgtatatt tttgttagtt tctgtacaga ttgtctttgc   1800

tcttgatttc ttttgctttg atgatttttg caacttgata gctaatgcac cttttctgtg   1860

aggaggaggg gatcgtgatt tcagaatgaa ttatgtatcc cttctctttt ggttttctct   1920

tgtttgcagt ctgctcagtt gttttatgta ttctcatatc aactgttaaa ctttttttta   1980

aggttaaaga atttaatcca ttgtgaaaca cttaactgga caaactgtag ttttagtaaa   2040

ttctagctgg agttaatata cgcctttata tgtgaaatct tgcccagtca cagaggtaga   2100

attgagcact cacagatgct ccagtaagaa tcacagtgct gggaatctag ttgctccaat   2160

atgaggcagc ttcatgtgca gcttagcact tgttgttgag atcggaccct gctggaagca   2220

gggaaaagaa gcgtgaagat cgtaggattg agaacttagg gaagcacatt agcttgcttg   2280

aagtgctgat tccatttcag ccaagcaagg gaaagaggaa gtggagtcat tttgcctttg   2340

aaggctgagg aaagattgat acccagttaa ttttgtttgc taaaggatgg gggcaataat   2400

cggcccttga ggagctgcag cagtaggcat gtgctcagtc tgcaggaatt gttacctcac   2460

tcccacaggg tctagactag aaatccatca tctctatcgt tgatatcctt ccatccagga   2520

atagattttt cttactctac atatgtgtgt gtgcgtgcgt gtgtgtgcgt gtgtgggcat   2580

ggggttgtgt cctggttgtg atattgaggt cttccttcct aacaaattaa tactaaaatg   2640

aaacagcttt tcttgtgtcc ttaagacaaa ataaggaagg aaaacgtagc tgcagttgtc   2700

cacgatggat attggttctt taaaatatat ctgaaagtag tagtcagaat gaattatggt   2760

tggaaaactg aggaatcttc tggttgcagg tgcaaagtga ctttgtttat tcttgtctca   2820

gtctccttga tagccacttc actctgctac tactcaactt tctcctaaaa atacttcatc   2880

tattttcagt cctttctttc tgtctactca aaatggttct attaactttg cagtcatgag   2940

cttgttccag ttacagtccc tttgaagttc agggtgataa acagaatatt cttctgtaga   3000

ggaagagaaa ggagtgaaag tttagcccac tgagacctag agctttgtga tttcctaacc   3060

ttgaaactct gtaatcccta aagttaaaat ctccgcaagt ggcacaactt cagaactaat   3120

agtatcactt tgatttttct ttttcctccc ttagaaagtt tctctagttc tatagtttat   3180

ttgttgaagg tactatgacc aaagaatcag ctgctctaca ggaatagcat ggttccagtg   3240

aattagagaa aacctgctgt aaagccatgg tagtgtctaa gtggtatgtt attatgatgt   3300

actagcattt atttacagaa ttatttatta acgtttactt ccttcccctc tgtaaatgtc   3360

catgactatt gcccagagaa ggcttacccc tctctagggt tgcagttgct ttctttgtaa   3420

taagtatttt gccacacctg taaaaaaaaa aacctcactt ttaactctct gccttgtttg   3480

ggtaaaggca gtaactaagt ttatgtttca gaactgcaaa acaaacagga tagttaccaa   3540

tatggcccat gtgtcagatt gatttttgta gcctctcact gaatccaaca tatccacaag   3600

caagttatct gtctttctac ctgataatct aaattatcag gatatttgtt ttctgcctaa   3660

atgtttatac taagccgagg ggagagaggt acctagacca tgtcatctac gagcttcagt   3720

aactaaagaa aaaggaactt ccctgagtgg cttgaatgtg tttgcccaca gtctatatct   3780

atgtatatag aatgtctgta tgtattttac ttatttaata tacattgaat ggtaccttgc   3840

tacagtattt ctgacattta gagtagtgtt gaaatactcg gctagcatca gcaccactat   3900

agcactgtcc gtgtcatatg agtcactaat attaactcca gggacttctg gataggctaa   3960

tagatcattg gatacgaagg gctcttttga agcttcagta taccatgttt gcatagttta   4020

tctttaaaaa caactttaaa ggttcttttg tgagccagga tctcagactg ccgtagcatg   4080

atgctgtcca tctttagcgc atgggctgag aacacctctt ccctgaggct tctgaaggtt   4140

gctgtctgtc atgagtgcat gaaggaggcc aagagtttat gctatgggag gaaccagtca   4200

ctgatttgcc tagattctga gagtctggcc catagccaac cacattttcc tttgggataa   4260

tttatttcct gtggcatcta gccagaagaa attgaggatg tttcctttca cagctgctcc   4320

aagcctgttg cccaattcac ggtacaaggg agcacccctt ccctttcctc tgaaggtacg   4380

ccacccacct ccgtcgccca cctcagcgcc caggagcctt gggacttcct tccatatgat   4440

aaatcattct tcttcacgtc aatacacttc atattaattt ctagtacaga aaatcttgac   4500

agctatcaga atgccttggt catagtgttg ttgcaaaatt gaccatacag gtggcccatg   4560

tataaaatct gaattttagg ggtttgtccc cacctcgcat gctggctttt acagggaggt   4620

gtctgggatt cctcattagc aatcaaaact taattactgg gatgcagagt ccttacttta   4680

tcgccagccc gtaggcattt ctgaagtgca cttttttgaa acatcatttt gctaactctc   4740

agcagtgtct aattaaactg agcaatactt ttgtgaattt taattaatct cagcaaaacc   4800

atgatgggag agagtcctct gatggaaatg tagtccctgg attatgtgta acctttttat   4860

tgctcttaga tgcagaggat agaaagcatt ttttggtgca gtggtcttgt ggcaaacaca   4920

agaccctcta tgcgtctcca actgttatcc taatctagaa aatgaggact ggcccctggg   4980

caaaagtgac atgaggaatt tactctggaa gaggaaaatc tgggtggctt tccaaggcta   5040

agataggttt gtatttcacc ctgtggccaa gctacagaac ttctgagatt gtggaagaat   5100

ttttgcaacc agcagggaaa gaggcctctt actgcctaaa cacaaagtta cactgagctt   5160

ttctactgtc ctttgcctat tgctccctct atcatgtaaa gatctgggaa ggatgagagg   5220

cagggcctgc ttgtcatgag ctgcactctt ttctttttaa ctaatcattg acaattggaa   5280

gaaaattgac gttaaagaag tttctccatt gtcttactaa caaaaccttt tgggtttcat   5340

taattgtcct tgaaattgag ttcctttggc atttttcctt gcagtcatca gttaagcatg   5400

ttgcatcctg aattcacaga agtttagctt tgcaggtttg aatctctgta atttaactcc   5460

cgtggacttg gtcgagtttt cagcaggttg ggagccacct ctcttcattt cagcagtgag   5520

tcatcccttg acttttcaaa tgacagaatt ttttccaatt gtaaaattag cactgtaaaa   5580

caaagaacca aagtggcatc ctaagagttg ttaaacctga agtctagttt atgaggaatt   5640

gtccaagttg gagtttaaat agtatctgct tttgtctcaa agcatctaag ttattctgac   5700

agaaaatggt aagtcagctt tgcaggcaga tgcgcctctg ggcctcctac cttgctccac   5760

agctttctgg ccatcttgtc tcccaggcca tgccactgct ctgccacatg tcagcaaatt   5820

tctttccacc agtcttatag catcttacat gatcaaatca tcacagaata accccgtgat   5880

agattattga tagcaataga gaggggcttt gtcactgatt tttctctcag attccttttc   5940

catctctcat ccataaagga aggactgaaa tccaaaggca ttctcctttt gtacctacag   6000

tatccagaac ccacgtgggc agccttctgc ttatgacaat aattggccca ttgcatgcag   6060

agagaatgtc ttcatagaga gaatgtcatt aaatacttga atctgcatga cagtttgact   6120

tgaatgcaac agcaggaaaa ttttgcaagt tacataattg tatatacagt aggttttctt   6180

aagtctcttc ggttcatcct ttgtaatttg tgtgtgtatc tgtagtattg caggcttttg   6240

gagactattc ttacaggcag tatgtcagtc atcaaagaaa atgctgtcac ctgccattgt   6300

tgtatttgtg ggtatttata gttgtatgta tgtaaatgca tcagtgtgta gattgcatat   6360

cagtgtatgg tacatgtaca tcaaaattat ttttgtcctt aatcagtgtg atatgaaaag   6420

caagtacaac ctcataggac tgattatata atgaagttgt tgagagtata tatagtggta   6480

ttgttttatt aaacttaaac tcaaataata ttttgattaa aatttttaat aagactttat   6540

gctagaaaat tctttgagct ttgaatcacc agggcaaaaa tgactttcaa ctaaccttgt   6600

gaatcttttg cagtgtactg tgtgcaatac caagggcata gctccctgta atttgggaaa   6660

tacagaaaga aaagaaaaaa aaaaaaaaag gcagcctgtg cagtcttagt aactttagta   6720

ttaagagcac ttaaagtcaa actgacaatt ttgggcttat tacaaaatgt gatgctttaa   6780

agcacacgtt ctttattgtt gttgtaatta gtccataaaa aa                      6822


<210>  2204
<211>  513
<212>  PRT
<213>  Homosapiens

<400>  2204

Met Gly Ser Ser Trp Cys Leu Tyr Gly Cys Cys Asn Ala Gly Val Lys 
1               5                   10                  15      


Thr Thr Arg Leu Glu Ala His Ser Glu Met Gly Ser Thr Glu Ile Leu 
            20                  25                  30          


Glu Lys Glu Thr Pro Glu Asn Leu Ser Asn Gly Thr Ser Ser Asn Val 
        35                  40                  45              


Glu Ala Ala Lys Arg Leu Ala Lys Arg Leu Tyr Gln Leu Asp Arg Phe 
    50                  55                  60                  


Lys Arg Ser Asp Val Ala Lys His Leu Gly Lys Asn Asn Glu Phe Ser 
65                  70                  75                  80  


Lys Leu Val Ala Glu Glu Tyr Leu Lys Phe Phe Asp Phe Thr Gly Met 
                85                  90                  95      


Thr Leu Asp Gln Ser Leu Arg Tyr Phe Phe Lys Ala Phe Ser Leu Val 
            100                 105                 110         


Gly Glu Thr Gln Glu Arg Glu Arg Val Leu Ile His Phe Ser Asn Arg 
        115                 120                 125             


Tyr Phe Tyr Cys Asn Pro Asp Thr Ile Ala Ser Gln Asp Gly Val His 
    130                 135                 140                 


Cys Leu Thr Cys Ala Ile Met Leu Leu Asn Thr Asp Leu His Gly His 
145                 150                 155                 160 


Asn Ile Gly Lys Lys Met Thr Cys Gln Glu Phe Ile Ala Asn Leu Gln 
                165                 170                 175     


Gly Val Asn Glu Gly Val Asp Phe Ser Lys Asp Leu Leu Lys Ala Leu 
            180                 185                 190         


Tyr Asn Ser Ile Lys Asn Glu Lys Leu Glu Trp Ala Val Asp Asp Glu 
        195                 200                 205             


Glu Lys Lys Lys Ser Pro Ser Glu Ser Thr Glu Glu Lys Ala Asn Gly 
    210                 215                 220                 


Thr His Pro Lys Thr Ile Ser Arg Ile Gly Ser Thr Thr Asn Pro Phe 
225                 230                 235                 240 


Leu Asp Ile Pro His Asp Pro Asn Ala Ala Val Tyr Lys Ser Gly Phe 
                245                 250                 255     


Leu Ala Arg Lys Ile His Ala Asp Met Asp Gly Lys Lys Thr Pro Arg 
            260                 265                 270         


Gly Lys Arg Gly Trp Lys Thr Phe Tyr Ala Val Leu Lys Gly Thr Val 
        275                 280                 285             


Leu Tyr Leu Gln Lys Asp Glu Tyr Lys Pro Glu Lys Ala Leu Ser Glu 
    290                 295                 300                 


Glu Asp Leu Lys Asn Ala Val Ser Val His His Ala Leu Ala Ser Lys 
305                 310                 315                 320 


Ala Thr Asp Tyr Glu Lys Lys Pro Asn Val Phe Lys Leu Lys Thr Ala 
                325                 330                 335     


Asp Trp Arg Val Leu Leu Phe Gln Thr Gln Ser Pro Glu Glu Met Gln 
            340                 345                 350         


Gly Trp Ile Asn Lys Ile Asn Cys Val Ala Ala Val Phe Ser Ala Pro 
        355                 360                 365             


Pro Phe Pro Ala Ala Ile Gly Ser Gln Lys Lys Phe Ser Arg Pro Leu 
    370                 375                 380                 


Leu Pro Ala Thr Thr Thr Lys Leu Ser Gln Glu Glu Gln Leu Lys Ser 
385                 390                 395                 400 


His Glu Ser Lys Leu Lys Gln Ile Thr Thr Glu Leu Ala Glu His Arg 
                405                 410                 415     


Ser Tyr Pro Pro Asp Lys Lys Val Lys Ala Lys Asp Val Asp Glu Tyr 
            420                 425                 430         


Lys Leu Lys Asp His Tyr Leu Glu Phe Glu Lys Thr Arg Tyr Glu Met 
        435                 440                 445             


Tyr Val Ser Ile Leu Lys Glu Gly Gly Lys Glu Leu Leu Ser Asn Asp 
    450                 455                 460                 


Glu Ser Glu Ala Ala Gly Leu Lys Lys Ser His Ser Ser Pro Ser Leu 
465                 470                 475                 480 


Asn Pro Asp Thr Ser Pro Ile Thr Ala Lys Val Lys Arg Asn Val Ser 
                485                 490                 495     


Glu Arg Lys Asp His Arg Pro Glu Thr Pro Ser Ile Lys Gln Lys Val 
            500                 505                 510         


Thr 
    


<210>  2205
<211>  2880
<212>  DNA
<213>  Homosapiens

<400>  2205
attttttgct cagcccgcct gcgccgcttg ggacgcctct gcctttccct ccctcccttc     60

cccgacggct tctggcggcc aagcggatgt ggcgggtgat cgagccaccc tgcccagggg    120

cgcccagcac tggttcagtg aacagcattt tggacaggac atttggtgcc aggtctgagt    180

agccagtttg ctgaattatt gtcccagtca gccaggattg tgagctgttt gggaagtttc    240

gtggaagcgc ccaagtgcca gcacaggtgg agggacacct ggaggccagt ttcaggaact    300

tttgccacaa gtataaaaga cttcagaagt gcaaagatgc tgaaacagat actgtcggag    360

atgtacatag atcctgatct actggcagag ctcagcgaag aacagaaaca gatcctgttc    420

ttcaagatga gagaggaaca gatccgacga tggaaagaaa gagaagcagc tatggaaaga    480

aaggagtccc tgccagtgaa acccagacca aagaaagaga atggcaaatc ggttcattgg    540

aaacttggag ctgataagga agtctgggta tgggtgatgg gcgaacacca tctagataaa    600

ccctatgatg tgctctgtaa tgaaattatt gctgagaggg cccggctgaa agcagaacag    660

gaggcagaag agcccagaaa aactcactct gaagaattca ccaatagctt gaaaacaaaa    720

tcacagtacc atgatctgca ggctccggat aaccagcaga ctaaagacat ctggaagaaa    780

gtggcagaaa aggaggaact ggagcaagga tctaggccag caccaaccct ggaagaagag    840

aaaatccgat cactctccag ttcttcaaga aatattcaac aaatgttggc agattcaatc    900

aatcgtatga aggcatatgc atttcaccag aagaaagaat ctatgaagaa aaaacaagat    960

gaagaaataa atcaaataga agaagagaga acgaagcaga tttgtaagag ctggaaagaa   1020

gactcggaat ggcaggcatc tctgcgaaaa tccaaagcag ctgatgagaa gagacgctcc   1080

ttggctaaac aagcacgaga agactacaag aggttgtccc tcggggccca gaaaggaaga   1140

ggcggtgaga ggctgcaaag ccccttgcgt gttccgcaga aaccagaaag acctcccctt   1200

ccacccaagc ctcagttcct aaactcaggg gcatatcctc aaaaacctct tagaaatcag   1260

ggagtggtga ggacactgtc cagctctgcc caagaggaca tcatccggtg gtttaaagag   1320

gagcagctac cacttcgagc gggctaccag aaaacctcag acaccatagc cccctggttc   1380

catggaattc tcacactcaa gaaagcaaat gaacttcttc tgagcacagg catgcccggc   1440

agttttctca tccgagtcag tgaaaggatc aaaggctatg ccctgtccta tctgtcggag   1500

gacggctgta aacatttcct catcgatgcc tctgcagacg cctacagctt cctgggcgtg   1560

gaccagctac agcatgccac cttggcggat ttggtggaat atcacaagga ggaacccatc   1620

acttccctgg ggaaggagct ccttctctat ccctgtggtc agcaggacca gctgcctgac   1680

tacctggagc tgtttgagtg acagcctcca tcagggtcat cctacagcct ccaagcgggc   1740

tttcccctgg acaaatgcca ctgcaacatt tatgtgtgaa gccaaaatca ccctgcagca   1800

gagccaatac tgatcaactg aaagtaaagt atccatggag tcctcattga cacctctttt   1860

ctgcacaaat actggaattc aatgtcaaga gaaaatgacc tctgctcaaa agggagaaga   1920

gtctcaattt cagcaagtac ctgtcatgaa gggtatgacc ttaatgatgt acataaaata   1980

aaacaaatga agaaatggaa aacttttaga aattaaggtg tacttgaaaa cgaatatcta   2040

tcatatgacc cctgcactcc ctctgtatca tctcaggagg tttcaggggc ctgttgacat   2100

gaagtttcga agtttcatgt tggctttgga atggtagcaa aagcctttcc tggctgagat   2160

gatgcttaaa acacacctca cttattgtac atgttggaac caggacatga gagacataga   2220

aaaacagaag tcatgaatgt aaattgaatg agaggcttaa catgcatgaa aatacagatg   2280

gacctgcagg aaagtgagca aacatcgctg agtttgtttt cttgttcggg agaatggggc   2340

cggggctggc ctggcctccc ctggatatac tctatagtgc accaaaagga taaagcatct   2400

gtacatgtat ttttttattt tttatcagaa gtgcttagac aagaacagaa taagcaggct   2460

gtttggatgc tacttgtggt tgaattgtgt tcccccaaaa tatatggtga agtcttaacc   2520

cccatccccg tgaatgggac cttgtttgga aatagggtct ttgcagatat agtcaagatg   2580

aggtcacatt ggattagggt gggccccaaa tccaatgact ggcatcctta ggagaagaga   2640

gagttttggt aatagacaca aatgcagtgg gaagaagacc aggggacaag aggcaagttg   2700

gagtgatgca gccggaaggg aagggacacc aaggatctcc ggccaccagc agaagccagc   2760

agagaggcat gggacaggtt ccccacaagc cttagaagga agcatggccc tgacttcaga   2820

attccagact ccagaactgg aagaataaat gtctgttgtt ttaaaaaaaa aaaaaaaaaa   2880


<210>  2206
<211>  454
<212>  PRT
<213>  Homosapiens

<400>  2206

Met Leu Lys Gln Ile Leu Ser Glu Met Tyr Ile Asp Pro Asp Leu Leu 
1               5                   10                  15      


Ala Glu Leu Ser Glu Glu Gln Lys Gln Ile Leu Phe Phe Lys Met Arg 
            20                  25                  30          


Glu Glu Gln Ile Arg Arg Trp Lys Glu Arg Glu Ala Ala Met Glu Arg 
        35                  40                  45              


Lys Glu Ser Leu Pro Val Lys Pro Arg Pro Lys Lys Glu Asn Gly Lys 
    50                  55                  60                  


Ser Val His Trp Lys Leu Gly Ala Asp Lys Glu Val Trp Val Trp Val 
65                  70                  75                  80  


Met Gly Glu His His Leu Asp Lys Pro Tyr Asp Val Leu Cys Asn Glu 
                85                  90                  95      


Ile Ile Ala Glu Arg Ala Arg Leu Lys Ala Glu Gln Glu Ala Glu Glu 
            100                 105                 110         


Pro Arg Lys Thr His Ser Glu Glu Phe Thr Asn Ser Leu Lys Thr Lys 
        115                 120                 125             


Ser Gln Tyr His Asp Leu Gln Ala Pro Asp Asn Gln Gln Thr Lys Asp 
    130                 135                 140                 


Ile Trp Lys Lys Val Ala Glu Lys Glu Glu Leu Glu Gln Gly Ser Arg 
145                 150                 155                 160 


Pro Ala Pro Thr Leu Glu Glu Glu Lys Ile Arg Ser Leu Ser Ser Ser 
                165                 170                 175     


Ser Arg Asn Ile Gln Gln Met Leu Ala Asp Ser Ile Asn Arg Met Lys 
            180                 185                 190         


Ala Tyr Ala Phe His Gln Lys Lys Glu Ser Met Lys Lys Lys Gln Asp 
        195                 200                 205             


Glu Glu Ile Asn Gln Ile Glu Glu Glu Arg Thr Lys Gln Ile Cys Lys 
    210                 215                 220                 


Ser Trp Lys Glu Asp Ser Glu Trp Gln Ala Ser Leu Arg Lys Ser Lys 
225                 230                 235                 240 


Ala Ala Asp Glu Lys Arg Arg Ser Leu Ala Lys Gln Ala Arg Glu Asp 
                245                 250                 255     


Tyr Lys Arg Leu Ser Leu Gly Ala Gln Lys Gly Arg Gly Gly Glu Arg 
            260                 265                 270         


Leu Gln Ser Pro Leu Arg Val Pro Gln Lys Pro Glu Arg Pro Pro Leu 
        275                 280                 285             


Pro Pro Lys Pro Gln Phe Leu Asn Ser Gly Ala Tyr Pro Gln Lys Pro 
    290                 295                 300                 


Leu Arg Asn Gln Gly Val Val Arg Thr Leu Ser Ser Ser Ala Gln Glu 
305                 310                 315                 320 


Asp Ile Ile Arg Trp Phe Lys Glu Glu Gln Leu Pro Leu Arg Ala Gly 
                325                 330                 335     


Tyr Gln Lys Thr Ser Asp Thr Ile Ala Pro Trp Phe His Gly Ile Leu 
            340                 345                 350         


Thr Leu Lys Lys Ala Asn Glu Leu Leu Leu Ser Thr Gly Met Pro Gly 
        355                 360                 365             


Ser Phe Leu Ile Arg Val Ser Glu Arg Ile Lys Gly Tyr Ala Leu Ser 
    370                 375                 380                 


Tyr Leu Ser Glu Asp Gly Cys Lys His Phe Leu Ile Asp Ala Ser Ala 
385                 390                 395                 400 


Asp Ala Tyr Ser Phe Leu Gly Val Asp Gln Leu Gln His Ala Thr Leu 
                405                 410                 415     


Ala Asp Leu Val Glu Tyr His Lys Glu Glu Pro Ile Thr Ser Leu Gly 
            420                 425                 430         


Lys Glu Leu Leu Leu Tyr Pro Cys Gly Gln Gln Asp Gln Leu Pro Asp 
        435                 440                 445             


Tyr Leu Glu Leu Phe Glu 
    450                 


<210>  2207
<211>  3877
<212>  DNA
<213>  Homosapiens

<400>  2207
ctccttaggt ggaaaccctg ggagtagagt actgacagca aagaccggga aagaccatac     60

gtccccgggc aggggtgaca acaggtgtca tctttttgat ctcgtgtgtg gctgccttcc    120

tatttcaagg aaagacgcca aggtaatttt gacccagagg agcaatgatg tagccacctc    180

ctaaccttcc cttcttgaac ccccagttat gccaggattt actagagagt gtcaactcaa    240

ccagcaagcg gctccttcgg cttaacttgt ggttggagga gagaaccttt gtggggctgc    300

gttctcttag cagtgctcag aagtgacttg cctgagggtg gaccagaaga aaggaaaggt    360

cccctcttgc tgttggctgc acatcaggaa ggctgtgatg ggaatgaagg tgaaaacttg    420

gagatttcac ttcagtcatt gcttctgcct gcaagatcat cctttaaaag tagagaagct    480

gctctgtgtg gtggttaact ccaagaggca gaactcgttc tagaaggaaa tggatgcaag    540

cagctccggg ggccccaaac gcatgcttcc tgtggtctag cccagggaag cccttccgtg    600

ggggccccgg ctttgaggga tgccaccggt tctggacgca tggctgattc ctgaatgatg    660

atggttcgcc gggggctgct tgcgtggatt tcccgggtgg tggttttgct ggtgctcctc    720

tgctgtgcta tctctgtcct gtacatgttg gcctgcaccc caaaaggtga cgaggagcag    780

ctggcactgc ccagggccaa cagccccacg gggaaggagg ggtaccaggc cgtccttcag    840

gagtgggagg agcagcaccg caactacgtg agcagcctga agcggcagat cgcacagctc    900

aaggaggagc tgcaggagag gagtgagcag ctcaggaatg ggcagtacca agccagcgat    960

gctgctggcc tgggtctgga caggagcccc ccagagaaaa cccaggccga cctcctggcc   1020

ttcctgcact cgcaggtgga caaggcagag gtgaatgctg gcgtcaagct ggccacagag   1080

tatgcagcag tgcctttcga tagctttact ctacagaagg tgtaccagct ggagactggc   1140

cttacccgcc accccgagga gaagcctgtg aggaaggaca agcgggatga gttggtggaa   1200

gccattgaat cagccttgga gaccctgaac aatcctgcag agaacagccc caatcaccgt   1260

ccttacacgg cctctgattt catagaaggg atctaccgaa cagaaaggga caaagggaca   1320

ttgtatgagc tcaccttcaa aggggaccac aaacacgaat tcaaacggct catcttattt   1380

cgaccattca gccccatcat gaaagtgaaa aatgaaaagc tcaacatggc caacacgctt   1440

atcaatgtta tcgtgcctct agcaaaaagg gtggacaagt tccggcagtt catgcagaat   1500

ttcagggaga tgtgcattga gcaggatggg agagtccatc tcactgttgt ttactttggg   1560

aaagaagaaa taaatgaagt caaaggaata cttgaaaaca cttccaaagc tgccaacttc   1620

aggaacttta ccttcatcca gctgaatgga gaattttctc ggggaaaggg acttgatgtt   1680

ggagcccgct tctggaaggg aagcaacgtc cttctctttt tctgtgatgt ggacatctac   1740

ttcacatctg aattcctcaa tacgtgtagg ctgaatacac agccagggaa gaaggtattt   1800

tatccagttc ttttcagtca gtacaatcct ggcataatat acggccacca tgatgcagtc   1860

cctcccttgg aacagcagct ggtcataaag aaggaaactg gattttggag agactttgga   1920

tttgggatga cgtgtcagta tcggtcagac ttcatcaata taggtgggtt tgatctggac   1980

atcaaaggct ggggcggaga ggatgtgcac ctttatcgca agtatctcca cagcaacctc   2040

atagtggtac ggacgcctgt gcgaggactc ttccacctct ggcatgagaa gcgctgcatg   2100

gacgagctga cccccgagca gtacaagatg tgcatgcagt ccaaggccat gaacgaggca   2160

tcccacggcc agctgggcat gctggtgttc aggcacgaga tagaggctca ccttcgcaaa   2220

cagaaacaga agacaagtag caaaaaaaca tgaactccca gagaaggatt gtgggagaca   2280

ctttttcttt ccttttgcaa ttactgaaag tggctgcaac agagaaaaga cttccataaa   2340

ggacgacaaa agaattggac tgatgggtca gagatgagaa agcctccgat ttctctctgt   2400

tgggcttttt acaacagaaa tcaaaatctc cgctttgcct gcaaaagtaa cccagttgca   2460

ccctgtgaag tgtctgacaa aggcagaatg cttgtgagat tataagccta atggtgtgga   2520

ggttttgatg gtgtttacaa tacactgaga cctgttgttt tgtgtgctca ttgaaatatt   2580

catgatttaa gagcagtttt gtaaaaaatt cattagcatg aaaggcaagc atatttctcc   2640

tcatatgaat gagcctatca gcagggctct agtttctagg aatgctaaaa tatcagaagg   2700

caggagagga gataggctta ttatgatact agtgagtaca ttaagtaaaa taaaatggac   2760

cagaaaagaa aagaaaccat aaatatcgtg tcatattttc cccaagatta accaaaaata   2820

atctgcttat ctttttggtt gtccttttaa ctgtctccgt ttttttcttt tatttaaaaa   2880

tgcacttttt ttcccttgtg agttatagtc tgcttattta attaccactt tgcaagcctt   2940

acaagagagc acaagttggc ctacattttt atatttttta agaagatact ttgagatgca   3000

ttatgagaac tttcagttca aagcatcaaa ttgatgccat atccaaggac atgccaaatg   3060

ctgattctgt caggcactga atgtcaggca ttgagacata gggaaggaat ggtttgtact   3120

aatacagacg tacagatact ttctctgaag agtattttcg aagaggagca actgaacact   3180

ggaggaaaag aaaatgacac tttctgcttt acagaaaagg aaactcattc agactggtga   3240

tatcgtgatg tacctaaaag tcagaaacca cattttctcc tcagaagtag ggaccgcttt   3300

cttacctgtt taaataaacc aaagtatacc gtgtgaacca aacaatctct tttcaaaaca   3360

gggtgctcct cctggcttct ggcttccata agaagaaatg gagaaaaata tatatatata   3420

tatatatatt gtgaaagatc aatccatctg ccagaatcta gtgggatgga agtttttgct   3480

acatgttatc caccccaggc caggtggaag taactgaatt attttttaaa ttaagcagtt   3540

ctactcaatc accaagatgc ttctgaaaat tgcattttat taccatttca aactattttt   3600

taaaaataaa tacagttaac atagagtggt ttcttcattc atgtgaaaat tattagccag   3660

caccagatgc atgagctaat tatctctttg agtccttgct tctgtttgct cacagtaaac   3720

tcattgttta aaagcttcaa gaacattcaa gctgttggtg tgttaaaaaa tgcattgtat   3780

tgatttgtac tggtagttta tgaaatttaa ttaaaacaca ggccatgaat ggaaggtggt   3840

attgcacagc taataaaata tgatttgtgg atatgaa                            3877


<210>  2208
<211>  532
<212>  PRT
<213>  Homosapiens

<400>  2208

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


Gln Tyr Gln Ala Ser Asp Ala Ala Gly Leu Gly Leu Asp Arg Ser Pro 
            100                 105                 110         


Pro Glu Lys Thr Gln Ala Asp Leu Leu Ala Phe Leu His Ser Gln Val 
        115                 120                 125             


Asp Lys Ala Glu Val Asn Ala Gly Val Lys Leu Ala Thr Glu Tyr Ala 
    130                 135                 140                 


Ala Val Pro Phe Asp Ser Phe Thr Leu Gln Lys Val Tyr Gln Leu Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Ala Ile Glu Ser Ala Leu Glu Thr Leu Asn 
            180                 185                 190         


Asn Pro Ala Glu Asn Ser Pro Asn His Arg Pro Tyr Thr Ala Ser Asp 
        195                 200                 205             


Phe Ile Glu Gly Ile Tyr Arg Thr Glu Arg Asp Lys Gly Thr Leu Tyr 
    210                 215                 220                 


Glu Leu Thr Phe Lys Gly Asp His Lys His Glu Phe Lys Arg Leu Ile 
225                 230                 235                 240 


Leu Phe Arg Pro Phe Ser Pro Ile Met Lys Val Lys Asn Glu Lys Leu 
                245                 250                 255     


Asn Met Ala Asn Thr Leu Ile Asn Val Ile Val Pro Leu Ala Lys Arg 
            260                 265                 270         


Val Asp Lys Phe Arg Gln Phe Met Gln Asn Phe Arg Glu Met Cys Ile 
        275                 280                 285             


Glu Gln Asp Gly Arg Val His Leu Thr Val Val Tyr Phe Gly Lys Glu 
    290                 295                 300                 


Glu Ile Asn Glu Val Lys Gly Ile Leu Glu Asn Thr Ser Lys Ala Ala 
305                 310                 315                 320 


Asn Phe Arg Asn Phe Thr Phe Ile Gln Leu Asn Gly Glu Phe Ser Arg 
                325                 330                 335     


Gly Lys Gly Leu Asp Val Gly Ala Arg Phe Trp Lys Gly Ser Asn Val 
            340                 345                 350         


Leu Leu Phe Phe Cys Asp Val Asp Ile Tyr Phe Thr Ser Glu Phe Leu 
        355                 360                 365             


Asn Thr Cys Arg Leu Asn Thr Gln Pro Gly Lys Lys Val Phe Tyr Pro 
    370                 375                 380                 


Val Leu Phe Ser Gln Tyr Asn Pro Gly Ile Ile Tyr Gly His His Asp 
385                 390                 395                 400 


Ala Val Pro Pro Leu Glu Gln Gln Leu Val Ile Lys Lys Glu Thr Gly 
                405                 410                 415     


Phe Trp Arg Asp Phe Gly Phe Gly Met Thr Cys Gln Tyr Arg Ser Asp 
            420                 425                 430         


Phe Ile Asn Ile Gly Gly Phe Asp Leu Asp Ile Lys Gly Trp Gly Gly 
        435                 440                 445             


Glu Asp Val His Leu Tyr Arg Lys Tyr Leu His Ser Asn Leu Ile Val 
    450                 455                 460                 


Val Arg Thr Pro Val Arg Gly Leu Phe His Leu Trp His Glu Lys Arg 
465                 470                 475                 480 


Cys Met Asp Glu Leu Thr Pro Glu Gln Tyr Lys Met Cys Met Gln Ser 
                485                 490                 495     


Lys Ala Met Asn Glu Ala Ser His Gly Gln Leu Gly Met Leu Val Phe 
            500                 505                 510         


Arg His Glu Ile Glu Ala His Leu Arg Lys Gln Lys Gln Lys Thr Ser 
        515                 520                 525             


Ser Lys Lys Thr 
    530         


<210>  2209
<211>  1870
<212>  DNA
<213>  Homosapiens

<400>  2209
cttcagagaa gggaaacaca cggctaagaa gagagaggca agggcaggag tgaaggagag     60

agctgaagcc tggggctccg agatggtcag aggatgggag acggggcagt gaaacaaggc    120

ttcttgtatc ttcagcagca gcagacgttt ggaaagaaat ggcgccgctt cggcgcctca    180

ctgtatggag ggtcggactg cgccttggcc cggctggagc tgcaggaggg cccggagaag    240

cctcgtcggt gtgaggctgc ccggaaggtc atccgcctca gtgactgcct gcgggtggcc    300

gaggccggcg gagaggccag cagcccccgg gacaccagtg ccttcttcct ggagaccaag    360

gagcgcctgt acctcctggc ggcccctgca gcggagcgcg gcgactgggt gcaggccatc    420

tgcctcctgg ccttccccgg gcagaggaag gagctctcgg ggccagaggg aaagcagagc    480

cggccctgca tggaggaaaa tgaattgtac agcagcgcag tcacagtcgg cccccacaag    540

gaatttgctg tgaccatgag acctacagaa gccagtgaga ggtgccacct gcgggggtcc    600

tataccctcc gggctgggga gagtgccctg gagctgtggg gtgggcccga gccagggacc    660

cagctgtacg actggcccta caggtttctg cggcgctttg ggcgggacaa ggtaaccttt    720

tcctttgagg caggccgtcg ctgcgtctct ggagagggca actttgagtt cgaaacccgg    780

caaggcaatg agatcttctt ggccctggaa gaggccatct ctgcccagaa gaatgctgca    840

cccgctacac cccaaccgca gccagccaca atccccgcgt cgctgccccg gcctgatagc    900

ccctactctc ggccgcatga ctcactgccg ccgccttcac ccaccacacc ggtgcctgct    960

ccacggcctc ggggccagga gggggagtat gccgtgccct tcgatgcggt ggcccgttcc   1020

ttggggaaga acttcagggg catcttggca gtccctcctc agctcctggc cgaccctctg   1080

tacgacagca ttgaggagac cctgccccct cgacctgacc acatatacga tgagcccgag   1140

ggagtggctg ccctgtccct ctatgacagc ccgcaggagc cccggggtga ggcatggagg   1200

aggcaggcga cagctgacag ggaccctgct ggcctccagc atgtccagcc agccgggcag   1260

gatttctctg cttctggctg gcagccagga actgagtatg acaatgttgt actaaagaaa   1320

ggcccaaagt gacagaggca gcagagggat ggtccaccgc cccttggctt ctgctggtga   1380

ctcctcctgg ccactgcatc agaagaacct cctctgcccc ttctggagcc cgaggcctgg   1440

cctgtcttcg ttggggctga taaattgcct ctcccagggc ctgctgggtg agtcaccatc   1500

ccaaagcagg aagggtgccc tggagagaac caccctcctc ctactctttt tccacttcct   1560

cctctttctt tccccagctg aggaggaacc tggggcattt agggcagagg acaaaaggat   1620

gtcagcaatt gcttgggctg cttggctatg caagcctcct gcctgctgat ggccacttca   1680

gggacagcct gggcccaggc acccaggggg atggcggcag cttcctgcac ctttcagatt   1740

tcttggtggc attaaagcat tttcagaaca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1860

aaaaaaaaaa                                                          1870


<210>  2210
<211>  412
<212>  PRT
<213>  Homosapiens

<400>  2210

Met Gly Asp Gly Ala Val Lys Gln Gly Phe Leu Tyr Leu Gln Gln Gln 
1               5                   10                  15      


Gln Thr Phe Gly Lys Lys Trp Arg Arg Phe Gly Ala Ser Leu Tyr Gly 
            20                  25                  30          


Gly Ser Asp Cys Ala Leu Ala Arg Leu Glu Leu Gln Glu Gly Pro Glu 
        35                  40                  45              


Lys Pro Arg Arg Cys Glu Ala Ala Arg Lys Val Ile Arg Leu Ser Asp 
    50                  55                  60                  


Cys Leu Arg Val Ala Glu Ala Gly Gly Glu Ala Ser Ser Pro Arg Asp 
65                  70                  75                  80  


Thr Ser Ala Phe Phe Leu Glu Thr Lys Glu Arg Leu Tyr Leu Leu Ala 
                85                  90                  95      


Ala Pro Ala Ala Glu Arg Gly Asp Trp Val Gln Ala Ile Cys Leu Leu 
            100                 105                 110         


Ala Phe Pro Gly Gln Arg Lys Glu Leu Ser Gly Pro Glu Gly Lys Gln 
        115                 120                 125             


Ser Arg Pro Cys Met Glu Glu Asn Glu Leu Tyr Ser Ser Ala Val Thr 
    130                 135                 140                 


Val Gly Pro His Lys Glu Phe Ala Val Thr Met Arg Pro Thr Glu Ala 
145                 150                 155                 160 


Ser Glu Arg Cys His Leu Arg Gly Ser Tyr Thr Leu Arg Ala Gly Glu 
                165                 170                 175     


Ser Ala Leu Glu Leu Trp Gly Gly Pro Glu Pro Gly Thr Gln Leu Tyr 
            180                 185                 190         


Asp Trp Pro Tyr Arg Phe Leu Arg Arg Phe Gly Arg Asp Lys Val Thr 
        195                 200                 205             


Phe Ser Phe Glu Ala Gly Arg Arg Cys Val Ser Gly Glu Gly Asn Phe 
    210                 215                 220                 


Glu Phe Glu Thr Arg Gln Gly Asn Glu Ile Phe Leu Ala Leu Glu Glu 
225                 230                 235                 240 


Ala Ile Ser Ala Gln Lys Asn Ala Ala Pro Ala Thr Pro Gln Pro Gln 
                245                 250                 255     


Pro Ala Thr Ile Pro Ala Ser Leu Pro Arg Pro Asp Ser Pro Tyr Ser 
            260                 265                 270         


Arg Pro His Asp Ser Leu Pro Pro Pro Ser Pro Thr Thr Pro Val Pro 
        275                 280                 285             


Ala Pro Arg Pro Arg Gly Gln Glu Gly Glu Tyr Ala Val Pro Phe Asp 
    290                 295                 300                 


Ala Val Ala Arg Ser Leu Gly Lys Asn Phe Arg Gly Ile Leu Ala Val 
305                 310                 315                 320 


Pro Pro Gln Leu Leu Ala Asp Pro Leu Tyr Asp Ser Ile Glu Glu Thr 
                325                 330                 335     


Leu Pro Pro Arg Pro Asp His Ile Tyr Asp Glu Pro Glu Gly Val Ala 
            340                 345                 350         


Ala Leu Ser Leu Tyr Asp Ser Pro Gln Glu Pro Arg Gly Glu Ala Trp 
        355                 360                 365             


Arg Arg Gln Ala Thr Ala Asp Arg Asp Pro Ala Gly Leu Gln His Val 
    370                 375                 380                 


Gln Pro Ala Gly Gln Asp Phe Ser Ala Ser Gly Trp Gln Pro Gly Thr 
385                 390                 395                 400 


Glu Tyr Asp Asn Val Val Leu Lys Lys Gly Pro Lys 
                405                 410         


<210>  2211
<211>  3765
<212>  DNA
<213>  Homosapiens

<400>  2211
agcggagcgg cgacggcgtc ggcggcggcg gcggcagcgg ctccggccga ggtgcgcgct     60

gggggggagg gggggccgga gaggagcatg aatggagcaa aatggcggat catgtgcaga    120

gcctggccca actagagaat ctgtgcaaac agctgtatga aaccacagac acaaccactc    180

gactccaggc agagaaagcc ttggttgaat ttaccaacag ccctgattgc ctgagcaagt    240

gccagctact cctcgaaaga ggaagttcct cttactccca gttactggca gctacatgcc    300

ttaccaagct tgtatcacgc acaaacaacc ccctaccatt ggaacagcga atagatattc    360

ggaactatgt gctcaactac cttgccactc ggccgaagtt ggctactttc gtgacacaag    420

cacttattca gttatatgcc agaatcacaa aactgggctg gtttgactgt cagaaggatg    480

actatgtctt cagaaatgca atcacagacg tcacaaggtt tttacaggat agtgttgaat    540

actgcatcat tggtgtcaca attttatctc agctaaccaa tgaaattaat caagcagaca    600

ccacccatcc tttaaccaag cacagaaaaa tagcctcttc ttttcgcgat tcatcattat    660

ttgatatctt cacactttcc tgcaatttac taaaacaggc ttcaggaaag aatctaaact    720

tgaatgatga aagtcagcat ggcttgctca tgcaactgct caagctcact cataactgcc    780

tcaactttga cttcatcggc acttccactg atgagtcctc agacgacctg tgtacagtgc    840

agattcccac cagctggaga tcagccttct tagattcttc aaccttgcag ctgttttttg    900

acctgtatca ttccatccct ccttcatttt cacctctggt attatcctgc ttggtacaga    960

tcgcttcagt cagaagatcc ctgtttaaca atgcagagag ggccaagttt ctctctcatc   1020

ttgttgatgg tgttaaacga atactggaaa acccacagag tttatcagac ccaaacaatt   1080

accatgagtt ttgcagacta ctggcccgat tgaagagtaa ctatcaactg ggagaattgg   1140

taaaggtgga aaactaccct gaggtcatcc gattgatagc caacttcaca gtgaccagcc   1200

tacagcactg ggaatttgct ccaaatagtg tgcactatct tctgagcctg tggcagcggc   1260

tggcagcctc tgtgccgtat gtcaaagcca cagaccccca catgctggaa acttacactc   1320

ctgaggtcac caaagcctac atcacatccc ggttggaatc tgtgcacatc atactgagag   1380

atggcctgga agatcccctg gaggatacgg ggctggtcca gcagcagttg gaccagctgt   1440

ccaccattgg gcgttgtgaa tatgagaaga cgtgtgcact cctcgtgcag ttgtttgacc   1500

agtcggccca gtcgtaccag gagctgctac agagcgccag cgcaagccca atggacattg   1560

cagtgcagga gggaaggctg acatggctgg tttacattat tggagcagtg atcggtggcc   1620

gggtttcttt tgccagcact gatgagcaag acgccatgga tggtgagctt gtctgtcggg   1680

tgctccagct gatgaaccta acagattctc gtttggccca ggcgggtaat gagaagctag   1740

agttggccat gctgagcttt tttgaacagt ttcgtaagat ctacattggg gaccaagtgc   1800

agaaatcctc taagctgtac cgccgactct cagaagttct gggcttgaat gatgagacca   1860

tggtcctaag cgtcttcata ggaaaaatca tcaccaactt gaagtactgg ggccgttgtg   1920

aaccaatcac ctccaagaca ctacagcttc tcaatgacct gtccattggg tacagtagcg   1980

taaggaagct agtgaagctt agtgcggtac agttcatgct gaacaatcac acgagcgagc   2040

acttttcatt tttgggtatt aacaatcagt ccaacctgac agacatgcgg tgtcggacta   2100

ccttctacac agcacttggg cgtctcctca tggtggattt aggagaggat gaagatcagt   2160

atgagcagtt catgctgcca ctcacagcag catttgaggc tgtggcccag atgtttagca   2220

ccaatagttt caacgagcag gaggcaaagc gaactctagt tggcctagta agagacctga   2280

gagggatcgc tttcgctttc aatgccaaga ccagcttcat gatgctcttt gaatggatat   2340

atccatccta tatgccaatt ctccaacggg caattgagct ctggtaccat gatccagcct   2400

gtactacacc tgtactcaag ttgatggctg aattggttca taataggtcc cagcgactcc   2460

agtttgatgt ctcttccccc aatggcatct tactcttccg agaaaccagc aagatgataa   2520

caatgtatgg caatcgcatc ctgacactag gagaggtccc aaaggatcag gtctatgctc   2580

tgaagctcaa gggcatctcc atctacttct ccatgctgaa ggctgctctc agtgggagtt   2640

acgtcaattt cggagtcttt cgtctctatg gagacgatgc cctggacaat gctctgcaga   2700

ccttcatcaa gctgctcctc tctattcctc acagtgatct cttggattac cccaagctca   2760

gccagtctta ttattcacta ctggaagtcc tgacccagga ccatatgaac tttattgcaa   2820

gcctggaacc tcacgtcatc atgtatattc tctcttccat ttctgaagga cttactgcac   2880

ttgacaccat ggtatgcaca ggctgctgct cctgcctgga ccacattgtg acatacctct   2940

tcaagcagct gtcacgtagc accaagaaga ggaccacacc cctgaaccag gagagcgacc   3000

gctttctgca catcatgcag cagcatccag agatgatcca gcagatgctg tccacggtgc   3060

tgaacatcat catctttgaa gactgtagga accagtggtc tatgtcccga ccactacttg   3120

gcttgatatt gcttaatgaa aagtattttt ctgacctaag aaacagtatt gtgaacagcc   3180

agccaccgga gaagcagcag gccatgcacc tgtgttttga gaacctgatg gaaggcatcg   3240

agcgaaatct tcttacgaaa aacagagaca ggttcaccca gaacctgtca gcattccgtc   3300

gagaagtcaa cgactcaatg aagaattcca cttatggcgt gaatagcaat gacatgatga   3360

gctgacacct ccttggactc tacctgtaca gagcagcgtc cctttggttt ggcccagagg   3420

ggcgaacaat tgcaagggag agggcctggc tgatcctggc tcttttctcc aggggtgtgg   3480

ggaaaatggc aaaggtcaac tagctgcttc cccagggaat aggggtgtga gtacactcac   3540

tagggggcag ggcgctgctg gttcctgggg gactgggtgg gaagggtggt gggaggagat   3600

aagagataca aactgagact ccagcctctc ctcctggggc cacccaagtg gggagaaccc   3660

ctagtgtcct gccataacct gccttgtata aacatgtaca ttttttcata acattttgaa   3720

caaggtttat attgactcaa gtttaaaaac gaaaaaaaaa aaaaa                   3765


<210>  2212
<211>  1087
<212>  PRT
<213>  Homosapiens

<400>  2212

Met Ala Asp His Val Gln Ser Leu Ala Gln Leu Glu Asn Leu Cys Lys 
1               5                   10                  15      


Gln Leu Tyr Glu Thr Thr Asp Thr Thr Thr Arg Leu Gln Ala Glu Lys 
            20                  25                  30          


Ala Leu Val Glu Phe Thr Asn Ser Pro Asp Cys Leu Ser Lys Cys Gln 
        35                  40                  45              


Leu Leu Leu Glu Arg Gly Ser Ser Ser Tyr Ser Gln Leu Leu Ala Ala 
    50                  55                  60                  


Thr Cys Leu Thr Lys Leu Val Ser Arg Thr Asn Asn Pro Leu Pro Leu 
65                  70                  75                  80  


Glu Gln Arg Ile Asp Ile Arg Asn Tyr Val Leu Asn Tyr Leu Ala Thr 
                85                  90                  95      


Arg Pro Lys Leu Ala Thr Phe Val Thr Gln Ala Leu Ile Gln Leu Tyr 
            100                 105                 110         


Ala Arg Ile Thr Lys Leu Gly Trp Phe Asp Cys Gln Lys Asp Asp Tyr 
        115                 120                 125             


Val Phe Arg Asn Ala Ile Thr Asp Val Thr Arg Phe Leu Gln Asp Ser 
    130                 135                 140                 


Val Glu Tyr Cys Ile Ile Gly Val Thr Ile Leu Ser Gln Leu Thr Asn 
145                 150                 155                 160 


Glu Ile Asn Gln Ala Asp Thr Thr His Pro Leu Thr Lys His Arg Lys 
                165                 170                 175     


Ile Ala Ser Ser Phe Arg Asp Ser Ser Leu Phe Asp Ile Phe Thr Leu 
            180                 185                 190         


Ser Cys Asn Leu Leu Lys Gln Ala Ser Gly Lys Asn Leu Asn Leu Asn 
        195                 200                 205             


Asp Glu Ser Gln His Gly Leu Leu Met Gln Leu Leu Lys Leu Thr His 
    210                 215                 220                 


Asn Cys Leu Asn Phe Asp Phe Ile Gly Thr Ser Thr Asp Glu Ser Ser 
225                 230                 235                 240 


Asp Asp Leu Cys Thr Val Gln Ile Pro Thr Ser Trp Arg Ser Ala Phe 
                245                 250                 255     


Leu Asp Ser Ser Thr Leu Gln Leu Phe Phe Asp Leu Tyr His Ser Ile 
            260                 265                 270         


Pro Pro Ser Phe Ser Pro Leu Val Leu Ser Cys Leu Val Gln Ile Ala 
        275                 280                 285             


Ser Val Arg Arg Ser Leu Phe Asn Asn Ala Glu Arg Ala Lys Phe Leu 
    290                 295                 300                 


Ser His Leu Val Asp Gly Val Lys Arg Ile Leu Glu Asn Pro Gln Ser 
305                 310                 315                 320 


Leu Ser Asp Pro Asn Asn Tyr His Glu Phe Cys Arg Leu Leu Ala Arg 
                325                 330                 335     


Leu Lys Ser Asn Tyr Gln Leu Gly Glu Leu Val Lys Val Glu Asn Tyr 
            340                 345                 350         


Pro Glu Val Ile Arg Leu Ile Ala Asn Phe Thr Val Thr Ser Leu Gln 
        355                 360                 365             


His Trp Glu Phe Ala Pro Asn Ser Val His Tyr Leu Leu Ser Leu Trp 
    370                 375                 380                 


Gln Arg Leu Ala Ala Ser Val Pro Tyr Val Lys Ala Thr Asp Pro His 
385                 390                 395                 400 


Met Leu Glu Thr Tyr Thr Pro Glu Val Thr Lys Ala Tyr Ile Thr Ser 
                405                 410                 415     


Arg Leu Glu Ser Val His Ile Ile Leu Arg Asp Gly Leu Glu Asp Pro 
            420                 425                 430         


Leu Glu Asp Thr Gly Leu Val Gln Gln Gln Leu Asp Gln Leu Ser Thr 
        435                 440                 445             


Ile Gly Arg Cys Glu Tyr Glu Lys Thr Cys Ala Leu Leu Val Gln Leu 
    450                 455                 460                 


Phe Asp Gln Ser Ala Gln Ser Tyr Gln Glu Leu Leu Gln Ser Ala Ser 
465                 470                 475                 480 


Ala Ser Pro Met Asp Ile Ala Val Gln Glu Gly Arg Leu Thr Trp Leu 
                485                 490                 495     


Val Tyr Ile Ile Gly Ala Val Ile Gly Gly Arg Val Ser Phe Ala Ser 
            500                 505                 510         


Thr Asp Glu Gln Asp Ala Met Asp Gly Glu Leu Val Cys Arg Val Leu 
        515                 520                 525             


Gln Leu Met Asn Leu Thr Asp Ser Arg Leu Ala Gln Ala Gly Asn Glu 
    530                 535                 540                 


Lys Leu Glu Leu Ala Met Leu Ser Phe Phe Glu Gln Phe Arg Lys Ile 
545                 550                 555                 560 


Tyr Ile Gly Asp Gln Val Gln Lys Ser Ser Lys Leu Tyr Arg Arg Leu 
                565                 570                 575     


Ser Glu Val Leu Gly Leu Asn Asp Glu Thr Met Val Leu Ser Val Phe 
            580                 585                 590         


Ile Gly Lys Ile Ile Thr Asn Leu Lys Tyr Trp Gly Arg Cys Glu Pro 
        595                 600                 605             


Ile Thr Ser Lys Thr Leu Gln Leu Leu Asn Asp Leu Ser Ile Gly Tyr 
    610                 615                 620                 


Ser Ser Val Arg Lys Leu Val Lys Leu Ser Ala Val Gln Phe Met Leu 
625                 630                 635                 640 


Asn Asn His Thr Ser Glu His Phe Ser Phe Leu Gly Ile Asn Asn Gln 
                645                 650                 655     


Ser Asn Leu Thr Asp Met Arg Cys Arg Thr Thr Phe Tyr Thr Ala Leu 
            660                 665                 670         


Gly Arg Leu Leu Met Val Asp Leu Gly Glu Asp Glu Asp Gln Tyr Glu 
        675                 680                 685             


Gln Phe Met Leu Pro Leu Thr Ala Ala Phe Glu Ala Val Ala Gln Met 
    690                 695                 700                 


Phe Ser Thr Asn Ser Phe Asn Glu Gln Glu Ala Lys Arg Thr Leu Val 
705                 710                 715                 720 


Gly Leu Val Arg Asp Leu Arg Gly Ile Ala Phe Ala Phe Asn Ala Lys 
                725                 730                 735     


Thr Ser Phe Met Met Leu Phe Glu Trp Ile Tyr Pro Ser Tyr Met Pro 
            740                 745                 750         


Ile Leu Gln Arg Ala Ile Glu Leu Trp Tyr His Asp Pro Ala Cys Thr 
        755                 760                 765             


Thr Pro Val Leu Lys Leu Met Ala Glu Leu Val His Asn Arg Ser Gln 
    770                 775                 780                 


Arg Leu Gln Phe Asp Val Ser Ser Pro Asn Gly Ile Leu Leu Phe Arg 
785                 790                 795                 800 


Glu Thr Ser Lys Met Ile Thr Met Tyr Gly Asn Arg Ile Leu Thr Leu 
                805                 810                 815     


Gly Glu Val Pro Lys Asp Gln Val Tyr Ala Leu Lys Leu Lys Gly Ile 
            820                 825                 830         


Ser Ile Tyr Phe Ser Met Leu Lys Ala Ala Leu Ser Gly Ser Tyr Val 
        835                 840                 845             


Asn Phe Gly Val Phe Arg Leu Tyr Gly Asp Asp Ala Leu Asp Asn Ala 
    850                 855                 860                 


Leu Gln Thr Phe Ile Lys Leu Leu Leu Ser Ile Pro His Ser Asp Leu 
865                 870                 875                 880 


Leu Asp Tyr Pro Lys Leu Ser Gln Ser Tyr Tyr Ser Leu Leu Glu Val 
                885                 890                 895     


Leu Thr Gln Asp His Met Asn Phe Ile Ala Ser Leu Glu Pro His Val 
            900                 905                 910         


Ile Met Tyr Ile Leu Ser Ser Ile Ser Glu Gly Leu Thr Ala Leu Asp 
        915                 920                 925             


Thr Met Val Cys Thr Gly Cys Cys Ser Cys Leu Asp His Ile Val Thr 
    930                 935                 940                 


Tyr Leu Phe Lys Gln Leu Ser Arg Ser Thr Lys Lys Arg Thr Thr Pro 
945                 950                 955                 960 


Leu Asn Gln Glu Ser Asp Arg Phe Leu His Ile Met Gln Gln His Pro 
                965                 970                 975     


Glu Met Ile Gln Gln Met Leu Ser Thr Val Leu Asn Ile Ile Ile Phe 
            980                 985                 990         


Glu Asp Cys Arg Asn Gln Trp Ser  Met Ser Arg Pro Leu  Leu Gly Leu 
        995                 1000                 1005             


Ile Leu  Leu Asn Glu Lys Tyr  Phe Ser Asp Leu Arg  Asn Ser Ile 
    1010                 1015                 1020             


Val Asn  Ser Gln Pro Pro Glu  Lys Gln Gln Ala Met  His Leu Cys 
    1025                 1030                 1035             


Phe Glu  Asn Leu Met Glu Gly  Ile Glu Arg Asn Leu  Leu Thr Lys 
    1040                 1045                 1050             


Asn Arg  Asp Arg Phe Thr Gln  Asn Leu Ser Ala Phe  Arg Arg Glu 
    1055                 1060                 1065             


Val Asn  Asp Ser Met Lys Asn  Ser Thr Tyr Gly Val  Asn Ser Asn 
    1070                 1075                 1080             


Asp Met  Met Ser 
    1085         


<210>  2213
<211>  1118
<212>  DNA
<213>  Homosapiens

<400>  2213
ggggggagct gggacctaag ccgcgcgcac acccctttct ctgcgtctgg tggaggtgca     60

cagaggcttt tgagtcaggc ccaagcgcag ccaggtgacc tccccgcggc ctttcaagcc    120

tgagctcggt ggacagctcc ctctcccgtg agtcccgctg tcctgtacgc gcccggtcga    180

gccccgggct gcgcaccccg ctaggagctg cccggccagc ccgcttctct gcccggagcc    240

atgaatctca gtagcgccag tagcacggag gaaaaggcag tgacgaccgt gctctggggc    300

tgcgagctca gtcaggagag gcggacttgg accttcagac cccagctgga ggggaagcag    360

agctgcaggc tgttgcttca tacgatttgc ttgggggaga aagccaaaga ggagatgcat    420

cgcgtggaga tcctgccccc agcaaaccag gaggacaaga agatgcagcc ggtcaccatt    480

gcctcactcc aggcctcagt cctccccatg gtctccatgg taggagtgca gctttctccc    540

ccagttactt tccagctccg ggctggctca ggacccgtgt tcctcagtgg ccaggaacgt    600

tatgaagcat cagacctaac ctgggaggag gaggaggaag aagaagggga ggaggaggaa    660

gaggaagagg aagatgatga ggatgaggat gcagatatat ctctggagga gcaaagccct    720

gtcaaacaag tcaaaaggct ggtgccccag aagcaggcga gcgtggctaa gaaaaaaaag    780

ctggaaaaag aagaagagga aataagagcc agcgttagag acaagagccc tgtgaaaaag    840

gccaaagcca cagccagagc caagaagcca ggattcaaga aatgaggagc cacgccttgg    900

ggggcacggt gcaaagtggg ccttccctgg gctgtgctgc aggcacaggg tgcccctgtc    960

cagcccctcc acctgtgtct gaatgcaaca ggggtgttgc gggggcaaca tgagagcccc   1020

tcacccccaa ctctccactt tcaggaggcc cccagtgaag agccccacct cggggtcaca   1080

ataaagttgc ctggtcagga aaaaaaaaaa aaaaaaaa                           1118


<210>  2214
<211>  214
<212>  PRT
<213>  Homosapiens

<400>  2214

Met Asn Leu Ser Ser Ala Ser Ser Thr Glu Glu Lys Ala Val Thr Thr 
1               5                   10                  15      


Val Leu Trp Gly Cys Glu Leu Ser Gln Glu Arg Arg Thr Trp Thr Phe 
            20                  25                  30          


Arg Pro Gln Leu Glu Gly Lys Gln Ser Cys Arg Leu Leu Leu His Thr 
        35                  40                  45              


Ile Cys Leu Gly Glu Lys Ala Lys Glu Glu Met His Arg Val Glu Ile 
    50                  55                  60                  


Leu Pro Pro Ala Asn Gln Glu Asp Lys Lys Met Gln Pro Val Thr Ile 
65                  70                  75                  80  


Ala Ser Leu Gln Ala Ser Val Leu Pro Met Val Ser Met Val Gly Val 
                85                  90                  95      


Gln Leu Ser Pro Pro Val Thr Phe Gln Leu Arg Ala Gly Ser Gly Pro 
            100                 105                 110         


Val Phe Leu Ser Gly Gln Glu Arg Tyr Glu Ala Ser Asp Leu Thr Trp 
        115                 120                 125             


Glu Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu 
    130                 135                 140                 


Asp Asp Glu Asp Glu Asp Ala Asp Ile Ser Leu Glu Glu Gln Ser Pro 
145                 150                 155                 160 


Val Lys Gln Val Lys Arg Leu Val Pro Gln Lys Gln Ala Ser Val Ala 
                165                 170                 175     


Lys Lys Lys Lys Leu Glu Lys Glu Glu Glu Glu Ile Arg Ala Ser Val 
            180                 185                 190         


Arg Asp Lys Ser Pro Val Lys Lys Ala Lys Ala Thr Ala Arg Ala Lys 
        195                 200                 205             


Lys Pro Gly Phe Lys Lys 
    210                 


<210>  2215
<211>  1238
<212>  DNA
<213>  Homosapiens

<400>  2215
acctctccag cgatgggagc cgcccgcctg ctgcccaacc tcactctgtg cttacagctg     60

ctgattctct gctgtcaaac tcagggggag aatcacccgt ctcctaattt taaccagtac    120

gtgagggacc agggcgccat gaccgaccag ctgagcaggc ggcagatccg cgagtaccaa    180

ctctacagca ggaccagtgg caagcacgtg caggtcaccg ggcgtcgcat ctccgccacc    240

gccgaggacg gcaacaagtt tgccaagctc atagtggaga cggacacgtt tggcagccgg    300

gttcgcatca aaggggctga gagtgagaag tacatctgta tgaacaagag gggcaagctc    360

atcgggaagc ccagcgggaa gagcaaagac tgcgtgttca cggagatcgt gctggagaac    420

aactatacgg ccttccagaa cgcccggcac gagggctggt tcatggcctt cacgcggcag    480

gggcggcccc gccaggcttc ccgcagccgc cagaaccagc gcgaggccca cttcatcaag    540

cgcctctacc aaggccagct gcccttcccc aaccacgccg agaagcagaa gcagttcgag    600

tttgtgggct ccgcccccac ccgccggacc aagcgcacac ggcggcccca gcccctcacg    660

tagtctggga ggcagggggc agcagcccct gggccgcctc cccacccctt tcccttctta    720

atccaaggac tgggctgggg tggcgggagg ggagccagat ccccgaggga ggaccctgag    780

ggccgcgaag catccgagcc cccagctggg aaggggcagg ccggtgcccc aggggcggct    840

ggcacagtgc ccccttcccg gacgggtggc aggccctgga gaggaactga gtgtcaccct    900

gatctcaggc caccagcctc tgccggcctc ccagccgggc tcctgaagcc cgctgaaagg    960

tcagcgactg aaggccttgc agacaaccgt ctggaggtgg ctgtcctcaa aatctgcttc   1020

tcggatctcc ctcagtctgc ccccagcccc caaactcctc ctggctagac tgtaggaagg   1080

gacttttgtt tgtttgtttg tttcaggaaa aaagaaaggg agagagagga aaatagaggg   1140

ttgtccactc ctcacattcc acgacccagg cctgcacccc acccccaact cccagccccg   1200

gaataaaacc attttcctgc aaaaaaaaaa aaaaaaaa                           1238


<210>  2216
<211>  216
<212>  PRT
<213>  Homosapiens

<400>  2216

Met Gly Ala Ala Arg Leu Leu Pro Asn Leu Thr Leu Cys Leu Gln Leu 
1               5                   10                  15      


Leu Ile Leu Cys Cys Gln Thr Gln Gly Glu Asn His Pro Ser Pro Asn 
            20                  25                  30          


Phe Asn Gln Tyr Val Arg Asp Gln Gly Ala Met Thr Asp Gln Leu Ser 
        35                  40                  45              


Arg Arg Gln Ile Arg Glu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  


His Val Gln Val Thr Gly Arg Arg Ile Ser Ala Thr Ala Glu Asp Gly 
65                  70                  75                  80  


Asn Lys Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      


Val Arg Ile Lys Gly Ala Glu Ser Glu Lys Tyr Ile Cys Met Asn Lys 
            100                 105                 110         


Arg Gly Lys Leu Ile Gly Lys Pro Ser Gly Lys Ser Lys Asp Cys Val 
        115                 120                 125             


Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Phe Gln Asn Ala 
    130                 135                 140                 


Arg His Glu Gly Trp Phe Met Ala Phe Thr Arg Gln Gly Arg Pro Arg 
145                 150                 155                 160 


Gln Ala Ser Arg Ser Arg Gln Asn Gln Arg Glu Ala His Phe Ile Lys 
                165                 170                 175     


Arg Leu Tyr Gln Gly Gln Leu Pro Phe Pro Asn His Ala Glu Lys Gln 
            180                 185                 190         


Lys Gln Phe Glu Phe Val Gly Ser Ala Pro Thr Arg Arg Thr Lys Arg 
        195                 200                 205             


Thr Arg Arg Pro Gln Pro Leu Thr 
    210                 215     


<210>  2217
<211>  2727
<212>  DNA
<213>  Homosapiens

<400>  2217
cacgagaaga caggaggaag aaagggagag agggccaggc agtcgcactg tgaacagaac     60

aggagaaggc gaagcggggc aaagttccct gcccaccgac gccagcctgc ttggatgact    120

tgcctcgttt cataattcac ttactgtctg caccagccgg cctcagcctg gctggaccct    180

gctgcctgtg tggcccggag ccagaggccc ccacactccc agctgctctt ctacagatgc    240

catcaacgag caggactctg ggtggctcca ctgtctaagc ctggagagtc accgccgagg    300

gatgaggacg cgccagcccg ggggaacgcg ccagctgctt tcgcggcccc aagcgcgcag    360

tgcccagcag ccgcgccgag cctgacacgc tgtcctctcc cctcgcgcac agggctctgc    420

gagtgacccg gcgggcgagc tccgtgctgc atggaacggc tgcagaagca accacttacc    480

tcccccggga gcgtgagccc ctcccgagat tccagtgtgc ctggctctcc ctccagcatc    540

gtggccaaga tggacaatca ggtgctgggc tacaaggacc tggctgccat ccccaaggac    600

aaggccatcc tggacatcga gcggcccgac ctcatgatct acgagcctca cttcacttat    660

tccctcctgg aacacgtgga gctgcctcgc cagcgcgagc gctcgctgtc acccaaatcc    720

acatcccccc caccatcccc agaggtgtgg gcggacagcc ggtcgcctgg aatcatctct    780

caggcctcgg cccccagaac cactggaacc ccccggacca gcctgcccca tttccaccac    840

cctgagacct cccgcccaga ttccaacatc tacaagaagc ctcccatcta taagcagaga    900

gagtccgtgg gaggcagccc tcagaccaag cacctcatcg aggatctcat catcgagtca    960

tccaagtttc ctgcagccca gcccccagac cccaaccagc cagccaaaat cgaaaccgac   1020

tactggccat gccccccgtc tctggctgtt gtggagacag aatggaggaa gcggaaggcg   1080

tctcggaggg gagcagagga agaggaggag gaggaagatg acgactctgg agaggagatg   1140

aaggctctca gggagcgtca gagagaggaa ctcagtaagg ttacttccaa cttgggaaag   1200

atgatcttga aagaagagat ggaaaagtca ttgccgatcc gaaggaaaac ccgctctctg   1260

cctgaccgga cacccttcca tacctccttg caccagggaa cgtctaaatc ttcctctctc   1320

ccccgctatg gcaggaccac cctgagccgg ctacagtcca cagagttcag cccatcaggg   1380

agtgagactg gaagcccagg cctgcagaac ggagagggcc agagggggag gatggaccgg   1440

gggaactccc tgccctgtgt gctggagcag aagatctatc cctatgaaat gctagtggtg   1500

accaacaagg ggcgaaccaa gctgccaccg ggggtggatc ggatgcggct tgagaggcat   1560

ctgtctgccg aggacttctc aagggtattt gccatgtccc ctgaagagtt tggcaagctg   1620

gctctgtgga agcggaatga gctcaagaag aaggcctctc tcttctgatg gcccccacct   1680

gctccgggac ggccccctta cccctgctgc ttcagggttt ttccccggcg ggttgggagg   1740

ggcaggaggt ggggtggaaa tagggtgggc tcctttcctc aggtagagtg gggggccaaa   1800

acctctgcag tccccggcag tgagctatgg actttcttcc ccctcacgag gctgggggcc   1860

tcctgctctc gtccctggcc ctccctgtac agggcaaagc cagtctgggc tctggcacac   1920

agagttcatg tttgccgccc tctccctgcc cctcacccca gaggtgagag gaatgagggg   1980

cattggtggt taggccggtt ggctgtcttg aacagctgga gggaagatgc aggggtggga   2040

agcggccagg cagaaagagc tccaggctct tgtgtcgccc acccagccct cccatactca   2100

ctcctgacag ctttcctgca ctgcagcttc ctgctcctct gactctagtg ggaacaggcc   2160

ccagctcagc ctccgcgagg gaggtcaccc ctccacttca gcttgccctg acctccgctc   2220

gcaaaccccg agcttccaag ccttttgctc cagccctgcg gcttccccag aagcctgggc   2280

ttagggtgga gatgccgcct acccgatcct ggccctccac ctgcctccag gccacgaaat   2340

gggaattcca gcactaagcc aggcaccggg cagaagctgg gccttccgcc tcccttggat   2400

ggggtcaaga ggccaggcct ggcacatttt ggagtgtcct ggctaccagc tctcacacct   2460

acacccacgc accccctcac acactatgct ctctcaagaa tgtaatttat tggggccccc   2520

ccagctgctt tcctcacctg cccctgccct accttacacc cccagcttga cttctttcca   2580

gtccacgtgg atataatgat atctatattt ttgcccaggt ctgggtattg ctcctgccca   2640

gaccctgaca tccctttcca ctgtgtgtgt gaccatgctg ggggaggggg actctgcttg   2700

gaattaaaag gttgctttgg gtcccta                                       2727


<210>  2218
<211>  405
<212>  PRT
<213>  Homosapiens

<400>  2218

Met Glu Arg Leu Gln Lys Gln Pro Leu Thr Ser Pro Gly Ser Val Ser 
1               5                   10                  15      


Pro Ser Arg Asp Ser Ser Val Pro Gly Ser Pro Ser Ser Ile Val Ala 
            20                  25                  30          


Lys Met Asp Asn Gln Val Leu Gly Tyr Lys Asp Leu Ala Ala Ile Pro 
        35                  40                  45              


Lys Asp Lys Ala Ile Leu Asp Ile Glu Arg Pro Asp Leu Met Ile Tyr 
    50                  55                  60                  


Glu Pro His Phe Thr Tyr Ser Leu Leu Glu His Val Glu Leu Pro Arg 
65                  70                  75                  80  


Gln Arg Glu Arg Ser Leu Ser Pro Lys Ser Thr Ser Pro Pro Pro Ser 
                85                  90                  95      


Pro Glu Val Trp Ala Asp Ser Arg Ser Pro Gly Ile Ile Ser Gln Ala 
            100                 105                 110         


Ser Ala Pro Arg Thr Thr Gly Thr Pro Arg Thr Ser Leu Pro His Phe 
        115                 120                 125             


His His Pro Glu Thr Ser Arg Pro Asp Ser Asn Ile Tyr Lys Lys Pro 
    130                 135                 140                 


Pro Ile Tyr Lys Gln Arg Glu Ser Val Gly Gly Ser Pro Gln Thr Lys 
145                 150                 155                 160 


His Leu Ile Glu Asp Leu Ile Ile Glu Ser Ser Lys Phe Pro Ala Ala 
                165                 170                 175     


Gln Pro Pro Asp Pro Asn Gln Pro Ala Lys Ile Glu Thr Asp Tyr Trp 
            180                 185                 190         


Pro Cys Pro Pro Ser Leu Ala Val Val Glu Thr Glu Trp Arg Lys Arg 
        195                 200                 205             


Lys Ala Ser Arg Arg Gly Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp 
    210                 215                 220                 


Asp Ser Gly Glu Glu Met Lys Ala Leu Arg Glu Arg Gln Arg Glu Glu 
225                 230                 235                 240 


Leu Ser Lys Val Thr Ser Asn Leu Gly Lys Met Ile Leu Lys Glu Glu 
                245                 250                 255     


Met Glu Lys Ser Leu Pro Ile Arg Arg Lys Thr Arg Ser Leu Pro Asp 
            260                 265                 270         


Arg Thr Pro Phe His Thr Ser Leu His Gln Gly Thr Ser Lys Ser Ser 
        275                 280                 285             


Ser Leu Pro Arg Tyr Gly Arg Thr Thr Leu Ser Arg Leu Gln Ser Thr 
    290                 295                 300                 


Glu Phe Ser Pro Ser Gly Ser Glu Thr Gly Ser Pro Gly Leu Gln Asn 
305                 310                 315                 320 


Gly Glu Gly Gln Arg Gly Arg Met Asp Arg Gly Asn Ser Leu Pro Cys 
                325                 330                 335     


Val Leu Glu Gln Lys Ile Tyr Pro Tyr Glu Met Leu Val Val Thr Asn 
            340                 345                 350         


Lys Gly Arg Thr Lys Leu Pro Pro Gly Val Asp Arg Met Arg Leu Glu 
        355                 360                 365             


Arg His Leu Ser Ala Glu Asp Phe Ser Arg Val Phe Ala Met Ser Pro 
    370                 375                 380                 


Glu Glu Phe Gly Lys Leu Ala Leu Trp Lys Arg Asn Glu Leu Lys Lys 
385                 390                 395                 400 


Lys Ala Ser Leu Phe 
                405 


<210>  2219
<211>  3759
<212>  DNA
<213>  Homosapiens

<400>  2219
agagcgctgc cgccgccgct ttcgcccggg agccgggggc cgggcgccat catgctgagc     60

cggctcgggg cgctgctgca ggaagccgtg ggggcgcgcg agcccagcat tgacctgctg    120

caggccttcg tggagcactg gaagggcatc acgcactact acatcgagag cacagatgaa    180

agcacccccg ccaagaagac agacattccc tggcggctga agcagatgct ggatatcctg    240

gtgtatgaag agcagcagca ggcggccgcg ggtgaggcag ggccctgcct ggagtacctg    300

ctgcagcaca agatcctgga gactctctgc acgctgggca aggccgagta ccccccaggc    360

atgcggcagc aggtgttcca gttcttcagc aaggttctgg cgcaggtgca gcaccccctg    420

ctgcattacc tcagcgtcca caggcctgtg cagaaactcc tccgacttgg tgggactgct    480

tccggatccg ttacagaaaa ggaggaggtg cagttcacca ccgtcctctg ctccaagatc    540

cagcaggacc cagagctgct cgcctacatc ctggaaggta aaaagattgt aggtaggaag    600

aaagcatgcg gagaacccac tgccctgcct aaggacacaa ccagccacgg ggacaaggac    660

tgctcccacg atggtgctcc tgccaggccc cagctggacg gggagtcctg tggggcccag    720

gccttgaaca gccacatgcc tgctgagacc gaggagctgg acggtgggac cacagagagc    780

aacctgatta cctccctgct tgggctgtgc cagagcaaga agagtcgggt ggccttgaag    840

gcccaggaga acctgctgct cctggtgagc atggcctccc cagcagctgc cacctacctg    900

gtacagagca gcgcctgctg ccctgcgatc gtccggcacc tttgccagtt gtaccggtcc    960

atgcctgtct tcctggaccc cgcagacatt gccaccttag agggcatcag ctggaggtta   1020

cccagtgccc cgtctgatga ggcttccttc cctggcaagg aggccttggc tgccttcttg   1080

ggctggtttg attactgcga ccacctcatc acagaggcac acacggtggt tgcggacgcc   1140

ttggcgaagg ctgtggctga gaacttcttc gtggagaccc tgcagcccca gctcctgcac   1200

gtgtccgagc agagcatctt gacctccacc gccctcctca cagccatgct gcgccagctt   1260

cgctcccctg cgctgctgcg ggaggccgtg gctttcctcc tgggcacaga ccggcagcct   1320

gaagcccccg gggacaaccc ccacaccctg tatgctcatc tcatcgggca ttgtgaccac   1380

ctctctgatg agatcagcat caccacactc cggctgtttg aggagctgct gcagaagccc   1440

cacgagggga tcatccacag cctggtcctg cgcaaccttg agggccgccc ttacgtggcc   1500

tggggctcac cagagcctga gagctatgag gacaccctag acctggagga agacccctac   1560

ttcaccgaca gcttcctgga ttccggcttt caaactcccg caaagcctcg cctagctcct   1620

gctaccagtt acgatggcaa aacagcagtg accgagatcg tcaacagttt cctgtgcctg   1680

gtccccgagg aagccaagac ctctgccttc ctggaggaga caggctatga cacatacgtc   1740

cacgatgctt atggcctgtt ccaggagtgc agctcccgcg tcgcctcctg gggctggcct   1800

ctgaccccca cacctttgga cccccatgag cccgagcgac ctttcttcga gggccacttc   1860

ctccgagtgc tgtttgaccg catgtcccgg attctggatc agccatacag cctgaacctg   1920

caggtgacct cggtcctgtc ccggcttgcc ctcttccccc acccccatat tcatgagtac   1980

ctgctggatc cgtacatcag cctggccccc ggctgcagga gcctattctc cgtgttggtg   2040

agggtgatcg gggacttgat gcagagaatc cagagggtac cccagttccc aggcaagctg   2100

ctcctggtgc gcaagcagtt gacgggccag gctcctgggg agcagctgga ccaccagacc   2160

ctcctccagg gcgtggtggt gctggaggag ttctgcaagg agctggctgc cattgccttc   2220

gtcaagtttc ccccacatga tcctcgccag aacgtctccc cagccccgga agggcaggtc   2280

tgagccagca ccagggcggt gggagactcc tgtccacacc tctgccccag agctgcctcc   2340

tgcctggcac tgccgccaca ctcccctcct gggatggggc ttctgctccc gggctcactc   2400

aaggagactg cggcatgttg accacaccag actgggtttc agggaatggg catgccaggt   2460

gccaaggagc caaacagatg gctttccagg cagcaaggtc cttggggcct tcttggagga   2520

gcttgggtga cagccaggtg agcacccaga ccccagaccc tcatgtgctg tgtgcctggc   2580

cccttctgta ctggccattt gtggccaggg ccaagcctgt gactcaactc caggggcaag   2640

atggggagtg agctgatggc tccgagactg gtcaggagcc caggccagtg agatggggcc   2700

tggagccttg tctgtgtcac attaggtacc atgggagctg ctgagacctg acattttgtc   2760

ccctgcctac atggcttggc ccatggagaa ggagcagtga atgggatcgt cggggaagcc   2820

cctcttcctg ctctgctccc ctggaaactg ttgcaaaact cccagccgcc tcatggcaaa   2880

tgcccaaagc atgttccgca cccaggcggg ggcccctgct aatgagaacc ttggtgcagc   2940

tgcagccagg aggggagcgg gcccaggagc caggctcagg tccagctggt tcctctctgg   3000

cgccttctga acccgtctca gcaggtccac agcacctggg cagaggtcag agaccagggg   3060

aggccgggcc ttgccctccc ttctgcccag ggcccagtgt tcttgataga agacccttct   3120

ggggagccag ggagctcagg ggacagataa gggaaggacg ccccctgact ccaggcccct   3180

gagcctggcg ggaagtggct gcggcccagg cagccagtcc tggtggtgtt ctccctgcat   3240

gccctccgtg gctgggctgc caccccaccc ggcccgaatc tgtcttgacc tgcaggaata   3300

cacgggcggc gccaggcatt acctcacagc gggactacac agttgctggc tttgctcctg   3360

ggcaaggagg agcaggccag agcctctttt gcttcctttt cttgcccatg ccgcttctag   3420

aagccaggca caggttgcca agaggtgaca cgaaacagga ggaaactcag tgacctctgc   3480

ctctcccaca ttcctccccg cgggggagga cctcgccgct ctgaagagca ccgtgcacat   3540

gtgggtgcac aaacgtgggt gttggtgtgg acggggcgca gatctccgtg gatgaactgc   3600

gtctggactc ttagattcat aaaatattcg agggtttggg agtcacagac cctcccctct   3660

cctcagtgca ctttggcatt tgcacggtgt cttccccgga cagcacagca ataaatggtg   3720

tgattgcgtg gaaaaaaaaa aaaaaaaaaa aaaaaaaaa                          3759


<210>  2220
<211>  743
<212>  PRT
<213>  Homosapiens

<400>  2220

Met Leu Ser Arg Leu Gly Ala Leu Leu Gln Glu Ala Val Gly Ala Arg 
1               5                   10                  15      


Glu Pro Ser Ile Asp Leu Leu Gln Ala Phe Val Glu His Trp Lys Gly 
            20                  25                  30          


Ile Thr His Tyr Tyr Ile Glu Ser Thr Asp Glu Ser Thr Pro Ala Lys 
        35                  40                  45              


Lys Thr Asp Ile Pro Trp Arg Leu Lys Gln Met Leu Asp Ile Leu Val 
    50                  55                  60                  


Tyr Glu Glu Gln Gln Gln Ala Ala Ala Gly Glu Ala Gly Pro Cys Leu 
65                  70                  75                  80  


Glu Tyr Leu Leu Gln His Lys Ile Leu Glu Thr Leu Cys Thr Leu Gly 
                85                  90                  95      


Lys Ala Glu Tyr Pro Pro Gly Met Arg Gln Gln Val Phe Gln Phe Phe 
            100                 105                 110         


Ser Lys Val Leu Ala Gln Val Gln His Pro Leu Leu His Tyr Leu Ser 
        115                 120                 125             


Val His Arg Pro Val Gln Lys Leu Leu Arg Leu Gly Gly Thr Ala Ser 
    130                 135                 140                 


Gly Ser Val Thr Glu Lys Glu Glu Val Gln Phe Thr Thr Val Leu Cys 
145                 150                 155                 160 


Ser Lys Ile Gln Gln Asp Pro Glu Leu Leu Ala Tyr Ile Leu Glu Gly 
                165                 170                 175     


Lys Lys Ile Val Gly Arg Lys Lys Ala Cys Gly Glu Pro Thr Ala Leu 
            180                 185                 190         


Pro Lys Asp Thr Thr Ser His Gly Asp Lys Asp Cys Ser His Asp Gly 
        195                 200                 205             


Ala Pro Ala Arg Pro Gln Leu Asp Gly Glu Ser Cys Gly Ala Gln Ala 
    210                 215                 220                 


Leu Asn Ser His Met Pro Ala Glu Thr Glu Glu Leu Asp Gly Gly Thr 
225                 230                 235                 240 


Thr Glu Ser Asn Leu Ile Thr Ser Leu Leu Gly Leu Cys Gln Ser Lys 
                245                 250                 255     


Lys Ser Arg Val Ala Leu Lys Ala Gln Glu Asn Leu Leu Leu Leu Val 
            260                 265                 270         


Ser Met Ala Ser Pro Ala Ala Ala Thr Tyr Leu Val Gln Ser Ser Ala 
        275                 280                 285             


Cys Cys Pro Ala Ile Val Arg His Leu Cys Gln Leu Tyr Arg Ser Met 
    290                 295                 300                 


Pro Val Phe Leu Asp Pro Ala Asp Ile Ala Thr Leu Glu Gly Ile Ser 
305                 310                 315                 320 


Trp Arg Leu Pro Ser Ala Pro Ser Asp Glu Ala Ser Phe Pro Gly Lys 
                325                 330                 335     


Glu Ala Leu Ala Ala Phe Leu Gly Trp Phe Asp Tyr Cys Asp His Leu 
            340                 345                 350         


Ile Thr Glu Ala His Thr Val Val Ala Asp Ala Leu Ala Lys Ala Val 
        355                 360                 365             


Ala Glu Asn Phe Phe Val Glu Thr Leu Gln Pro Gln Leu Leu His Val 
    370                 375                 380                 


Ser Glu Gln Ser Ile Leu Thr Ser Thr Ala Leu Leu Thr Ala Met Leu 
385                 390                 395                 400 


Arg Gln Leu Arg Ser Pro Ala Leu Leu Arg Glu Ala Val Ala Phe Leu 
                405                 410                 415     


Leu Gly Thr Asp Arg Gln Pro Glu Ala Pro Gly Asp Asn Pro His Thr 
            420                 425                 430         


Leu Tyr Ala His Leu Ile Gly His Cys Asp His Leu Ser Asp Glu Ile 
        435                 440                 445             


Ser Ile Thr Thr Leu Arg Leu Phe Glu Glu Leu Leu Gln Lys Pro His 
    450                 455                 460                 


Glu Gly Ile Ile His Ser Leu Val Leu Arg Asn Leu Glu Gly Arg Pro 
465                 470                 475                 480 


Tyr Val Ala Trp Gly Ser Pro Glu Pro Glu Ser Tyr Glu Asp Thr Leu 
                485                 490                 495     


Asp Leu Glu Glu Asp Pro Tyr Phe Thr Asp Ser Phe Leu Asp Ser Gly 
            500                 505                 510         


Phe Gln Thr Pro Ala Lys Pro Arg Leu Ala Pro Ala Thr Ser Tyr Asp 
        515                 520                 525             


Gly Lys Thr Ala Val Thr Glu Ile Val Asn Ser Phe Leu Cys Leu Val 
    530                 535                 540                 


Pro Glu Glu Ala Lys Thr Ser Ala Phe Leu Glu Glu Thr Gly Tyr Asp 
545                 550                 555                 560 


Thr Tyr Val His Asp Ala Tyr Gly Leu Phe Gln Glu Cys Ser Ser Arg 
                565                 570                 575     


Val Ala Ser Trp Gly Trp Pro Leu Thr Pro Thr Pro Leu Asp Pro His 
            580                 585                 590         


Glu Pro Glu Arg Pro Phe Phe Glu Gly His Phe Leu Arg Val Leu Phe 
        595                 600                 605             


Asp Arg Met Ser Arg Ile Leu Asp Gln Pro Tyr Ser Leu Asn Leu Gln 
    610                 615                 620                 


Val Thr Ser Val Leu Ser Arg Leu Ala Leu Phe Pro His Pro His Ile 
625                 630                 635                 640 


His Glu Tyr Leu Leu Asp Pro Tyr Ile Ser Leu Ala Pro Gly Cys Arg 
                645                 650                 655     


Ser Leu Phe Ser Val Leu Val Arg Val Ile Gly Asp Leu Met Gln Arg 
            660                 665                 670         


Ile Gln Arg Val Pro Gln Phe Pro Gly Lys Leu Leu Leu Val Arg Lys 
        675                 680                 685             


Gln Leu Thr Gly Gln Ala Pro Gly Glu Gln Leu Asp His Gln Thr Leu 
    690                 695                 700                 


Leu Gln Gly Val Val Val Leu Glu Glu Phe Cys Lys Glu Leu Ala Ala 
705                 710                 715                 720 


Ile Ala Phe Val Lys Phe Pro Pro His Asp Pro Arg Gln Asn Val Ser 
                725                 730                 735     


Pro Ala Pro Glu Gly Gln Val 
            740             


<210>  2221
<211>  2249
<212>  DNA
<213>  Homosapiens

<400>  2221
agtgctgagg tggggtgaag gaggaaaggc cgagctggga gaggagcatg cgctcgccac     60

aaccaccccc accctgctct ccacgcgcca ggtcctgcac gctgggtggg agggtgacga    120

caaggatgga ggagcagggc cccacccccg ccctcccagg gcgcaccatc tgcagcagag    180

agggccttga gctgcgtggg aaatgcgaat ctccttcaag gcaggggttt atgtccccca    240

ccccacgggc catgtgacat ttataactct ttggtggaat gagaagaaag gtatttggga    300

tatgatcaac tccggcaatg ccattgtgtg tttacggcaa cagcgggaca gtggttccag    360

ggggcggccc cgggcctccg tgacgtcacc ggattgtcgc gtcaccgtcg cctaccccgg    420

cggcgcaacg cgccctgcag gaaagatgac gtcaccgtcg gagctcctgc agaccagtgc    480

gcgctcgggg agttggcgag cgggtggcgg ctgggagacg tcccgagcgc acgggactga    540

caggcggcag aagccgggcg gggtccgctg ggctccggac ccgtgccccc ccagttccag    600

ggcggccccg ggcggccccg ccccctcggt gaatgccgcg ggccggccaa tccgggcagg    660

ccgcggcgcc gcgcagccta tcagcggcca gagctcgcgt gcgcttccgc gttcgcgtgc    720

gcttccgcgt tctcgtgagc tcccggcccg ctgccgcagg gactgggagc gggctccgca    780

gcgcactcta gcccgcggct cggctcagtc ggtctgcgag gatccggccc gccgcccccc    840

gggggacccg atggcctcgg agggcctggc gggggcgctg gcttccgtgc tggctggcca    900

ggggtccagc gtgcacagct gcgactcggc gccggccggg gagccgccgg cgcccgtgcg    960

gctgcggaag aacgtgtgct acgtggtgct ggccgtgttc ctcagcgagc aggatgaggt   1020

gctactgatc caggaggcca agagggagtg ccgggggtcg tggtacctgc ctgcggggag   1080

aatggagcca ggggagacca tcgtggaggc gctgcagcgg gaggtgaagg aggaggcggg   1140

gctgcactgt gagcccgaga cactgctgtc cgtggaggag cggggcccct cctgggtccg   1200

cttcgtgttc ctcgctcgcc ccacaggtgg aattctcaag acttccaagg aggccgatgc   1260

ggagtccctg caggctgcct ggtacccacg gacctccctg cccactccgc tgcgagccca   1320

tgacatcctg cacctggttg aactagccgc ccagtatcgc cagcaagcca ggcaccctct   1380

cattctgccc caagagctac cctgtgatct ggtctgccag cggctcgtgg ctacctttac   1440

cagcgcccag acagtgtggg tgttagtggg cacagtgggg atgcctcact tgcctgtcac   1500

tgcctgtggc ctcgaccctg tggagcagag gggtggcatg aagatggccg tcctgcggct   1560

gctgcaggag tgtctgaccc tgcaccactt ggtggtggag atcaaggggt tgcttggact   1620

gcagcacctg ggccgagatc acagtgatgg catctgtttg aatgtgctgg tgaccgtggc   1680

ttttcggagc ccagggatcc aggatgaacc cccaaaagtt cggggtgaga acttctcttg   1740

gtggaaggtg atggaggaag acctgcaaag ccagctcctc cagcggcttc agggatcctc   1800

tgttgtccca gtgaacagat agagaggtgg aggaggtgac agggagctag gcagccgtgc   1860

tccctccagt gcggacttgt ctccctctga gggaggcaag aggctggcga tcagggatct   1920

tgttgcattg ggagcagggg cggctctcct ggtccccagg agagatgctt tgaggagcat   1980

tcctctagat tgcacaaggg acagtgcctt taaccaagcg aggagtccaa agctcaggac   2040

ctgactaccc tgagggcacg ctgacgcctc tccccagggg gatggggagc tttctgcacc   2100

cccagtggca tctcctcatc acgttctgtg ccgtccttgg gaaaggcctg cattctgatc   2160

cttccaggcc cttcgagcat ggaggggcac tggggaaggt cccccgaggg aggagcacgt   2220

tgctgagtaa agaggtgtta ctcaccttg                                     2249


<210>  2222
<211>  539
<212>  PRT
<213>  Homosapiens

<400>  2222

Met Arg Ile Ser Phe Lys Ala Gly Val Tyr Val Pro His Pro Thr Gly 
1               5                   10                  15      


His Val Thr Phe Ile Thr Leu Trp Trp Asn Glu Lys Lys Gly Ile Trp 
            20                  25                  30          


Asp Met Ile Asn Ser Gly Asn Ala Ile Val Cys Leu Arg Gln Gln Arg 
        35                  40                  45              


Asp Ser Gly Ser Arg Gly Arg Pro Arg Ala Ser Val Thr Ser Pro Asp 
    50                  55                  60                  


Cys Arg Val Thr Val Ala Tyr Pro Gly Gly Ala Thr Arg Pro Ala Gly 
65                  70                  75                  80  


Lys Met Thr Ser Pro Ser Glu Leu Leu Gln Thr Ser Ala Arg Ser Gly 
                85                  90                  95      


Ser Trp Arg Ala Gly Gly Gly Trp Glu Thr Ser Arg Ala His Gly Thr 
            100                 105                 110         


Asp Arg Arg Gln Lys Pro Gly Gly Val Arg Trp Ala Pro Asp Pro Cys 
        115                 120                 125             


Pro Pro Ser Ser Arg Ala Ala Pro Gly Gly Pro Ala Pro Ser Val Asn 
    130                 135                 140                 


Ala Ala Gly Arg Pro Ile Arg Ala Gly Arg Gly Ala Ala Gln Pro Ile 
145                 150                 155                 160 


Ser Gly Gln Ser Ser Arg Ala Leu Pro Arg Ser Arg Ala Leu Pro Arg 
                165                 170                 175     


Ser Arg Glu Leu Pro Ala Arg Cys Arg Arg Asp Trp Glu Arg Ala Pro 
            180                 185                 190         


Gln Arg Thr Leu Ala Arg Gly Ser Ala Gln Ser Val Cys Glu Asp Pro 
        195                 200                 205             


Ala Arg Arg Pro Pro Gly Asp Pro Met Ala Ser Glu Gly Leu Ala Gly 
    210                 215                 220                 


Ala Leu Ala Ser Val Leu Ala Gly Gln Gly Ser Ser Val His Ser Cys 
225                 230                 235                 240 


Asp Ser Ala Pro Ala Gly Glu Pro Pro Ala Pro Val Arg Leu Arg Lys 
                245                 250                 255     


Asn Val Cys Tyr Val Val Leu Ala Val Phe Leu Ser Glu Gln Asp Glu 
            260                 265                 270         


Val Leu Leu Ile Gln Glu Ala Lys Arg Glu Cys Arg Gly Ser Trp Tyr 
        275                 280                 285             


Leu Pro Ala Gly Arg Met Glu Pro Gly Glu Thr Ile Val Glu Ala Leu 
    290                 295                 300                 


Gln Arg Glu Val Lys Glu Glu Ala Gly Leu His Cys Glu Pro Glu Thr 
305                 310                 315                 320 


Leu Leu Ser Val Glu Glu Arg Gly Pro Ser Trp Val Arg Phe Val Phe 
                325                 330                 335     


Leu Ala Arg Pro Thr Gly Gly Ile Leu Lys Thr Ser Lys Glu Ala Asp 
            340                 345                 350         


Ala Glu Ser Leu Gln Ala Ala Trp Tyr Pro Arg Thr Ser Leu Pro Thr 
        355                 360                 365             


Pro Leu Arg Ala His Asp Ile Leu His Leu Val Glu Leu Ala Ala Gln 
    370                 375                 380                 


Tyr Arg Gln Gln Ala Arg His Pro Leu Ile Leu Pro Gln Glu Leu Pro 
385                 390                 395                 400 


Cys Asp Leu Val Cys Gln Arg Leu Val Ala Thr Phe Thr Ser Ala Gln 
                405                 410                 415     


Thr Val Trp Val Leu Val Gly Thr Val Gly Met Pro His Leu Pro Val 
            420                 425                 430         


Thr Ala Cys Gly Leu Asp Pro Val Glu Gln Arg Gly Gly Met Lys Met 
        435                 440                 445             


Ala Val Leu Arg Leu Leu Gln Glu Cys Leu Thr Leu His His Leu Val 
    450                 455                 460                 


Val Glu Ile Lys Gly Leu Leu Gly Leu Gln His Leu Gly Arg Asp His 
465                 470                 475                 480 


Ser Asp Gly Ile Cys Leu Asn Val Leu Val Thr Val Ala Phe Arg Ser 
                485                 490                 495     


Pro Gly Ile Gln Asp Glu Pro Pro Lys Val Arg Gly Glu Asn Phe Ser 
            500                 505                 510         


Trp Trp Lys Val Met Glu Glu Asp Leu Gln Ser Gln Leu Leu Gln Arg 
        515                 520                 525             


Leu Gln Gly Ser Ser Val Val Pro Val Asn Arg 
    530                 535                 


<210>  2223
<211>  4981
<212>  DNA
<213>  Homosapiens

<400>  2223
ggccccggag ctggcccatg gggagcaggc gcccggtgcc ggccacgacg accgccaccg     60

cccgcgccgc gaccggccgg tgaagcccag ggacccccct ctgggagagc cccatgaggg    120

caggagagtg atggagagta cgcccagctt cctgaagggc accccaacct gggagaagac    180

ggccccagag aacggcatcg tgagacagga gcccggcagc ccgcctcgag atggactgca    240

ccatgggccg ctgtgcctgg gagagcctgc tcccttttgg aggggcgtcc tgagcacccc    300

agactcctgg cttccccctg gcttccccca gggccccaag gacatgctcc cacttgtgga    360

gggcgagggc ccccagaatg gggagaggaa ggtcaactgg ctgggcagca aagagggact    420

gcgctggaag gaggccatgc ttacccatcc gctggcattc tgcgggccag cgtgcccacc    480

tcgctgtggc cccctgatgc ctgagcatag tggtggccat ctcaagagtg accctgtggc    540

cttccggccc tggcactgcc ctttccttct ggagaccaag atcctggagc gagctccctt    600

ctgggtgccc acctgcttgc caccctacct agtgtctggc ctgcccccag agcatccatg    660

tgactggccc ctgaccccgc acccctgggt atactccggg ggccagccca aagtgccctc    720

tgccttcagc ttaggcagca agggctttta ctacaaggat ccgagcattc ccaggttggc    780

aaaggagccc ttggcagctg cggaacctgg gttgtttggc ttaaactctg gtgggcacct    840

gcagagagcc ggggaggccg aacgcccttc actgcaccag agggatggag agatgggagc    900

tggccggcag cagaatcctt gcccgctctt cctggggcag ccagacactg tgccctggac    960

ctcctggccc gcttgtcccc caggccttgt tcatactctt ggcaacgtct gggctgggcc   1020

aggcgatggg aaccttgggt accagctggg gccaccagca acaccaaggt gcccctctcc   1080

tgagccgcct gtcacccagc ggggctgctg ttcatcctac ccacccacta aaggtggggg   1140

tcttggccct tgtgggaagt gccaggaggg cctggagggg ggtgccagtg gagccagcga   1200

acccagcgag gaagtgaaca aggcctctgg ccccagggcc tgtcccccca gccaccacac   1260

caagctgaag aagacatggc tcacacggca ctcggagcag tttgaatgtc cacgcggctg   1320

ccctgaggtc gaggagaggc cggttgctcg gctccgggcc ctcaaaaggg caggcagccc   1380

cgaggtccag ggagcaatgg gcagtccagc ccccaagcgg ccaccggacc cttttccagg   1440

cactgcagaa cagggggctg ggggttggca ggaggtgcgg gacacatcga tagggaacaa   1500

ggatgtggac tcgggacagc atgatgagca gaaaggaccc caagatggcc aggccagtct   1560

ccaggacccg ggacttcagg acataccatg cctggctctc cctgcaaaac tggctcaatg   1620

ccaaagttgt gcccaggcag ctggagaggg aggagggcac gcctgccact ctcagcaagt   1680

gcggagatcg cctctgggag gggagctgca gcaggaggaa gacacagcca ccaactccag   1740

ctctgaggaa ggcccagggt ccggccctga cagccggctc agcacaggcc tcgccaagca   1800

cctgctcagt ggtttggggg accgactgtg ccgcctgctg cggagggagc gggaggccct   1860

ggcttgggcc cagcgggaag gccaagggcc agccgtgaca gaggacagcc caggcattcc   1920

acgctgctgc agccgttgcc accatggact cttcaacacc cactggcgat gtccccgctg   1980

cagccaccgg ctgtgtgtgg cctgtggtcg tgtggcaggc actgggcggg ccagggagaa   2040

agcaggcttt caggagcagt ccgcggagga gtgcacgcag gaggccgggc acgctgcctg   2100

ttccctgatg ctgacccagt ttgtctccag ccaggctttg gcagagctga gcactgcaat   2160

gcaccaggtc tgggtcaagt ttgatatccg ggggcactgc ccctgccaag ctgatgcccg   2220

ggtatgggcc cccggggatg caggccagca gaaggaatca acacagaaaa cgcccccaac   2280

tccacaacct tcctgcaatg gcgacaccca caggaccaag agcatcaaag aggagacccc   2340

cgattccgct gagaccccag cagaggaccg tgctggccga gggcccctgc cttgtccttc   2400

tctctgcgaa ctgctggctt ctaccgcggt caaactctgc ttgggccatg agcgaataca   2460

catggccttc gcccccgtca ctccggccct gcccagtgat gaccgcatca ccaacatcct   2520

ggacagcatt atcgcacagg tggtggaacg gaagatccag gagaaagccc tggggccggg   2580

gcttcgagct ggcccgggtc tgcgcaaggg cctgggcctg cccctctctc cagtgcggcc   2640

ccggctgcct cccccagggg ctttgctgtg gctgcaggag ccccagcctt gccctcggcg   2700

tggcttccac ctcttccagg agcactggag gcagggccag cctgtgttgg tgtcagggat   2760

ccaaaggaca ttgcagggca acctgtgggg gacagaagct cttggggcac ttggaggcca   2820

ggtgcaggcg ctgagccccc tcggacctcc ccagcccagc agcctgggca gcacaacatt   2880

ctgggagggc ttctcctggc ctgagcttcg cccaaagtca gacgagggct ctgtcctcct   2940

gctgcaccga gctttggggg atgaggacac cagcagggtg gagaacctag ctgccagtct   3000

gccacttccg gagtactgcg ccctccatgg aaaactcaac ctggcttcct acctcccacc   3060

gggccttgcc ctgcgtccac tggagcccca gctctgggca gcctatggtg tgagcccgca   3120

ccggggacac ctggggacca agaacctctg tgtggaggtg gccgacctgg tcagcatcct   3180

ggtgcatgcc gacacaccac tgcctgcctg gcaccgggca cagaaagact tcctttcagg   3240

cctggacggg gaggggctct ggtctccggg cagccaggtc agcactgtgt ggcacgtgtt   3300

ccgggcacag gacgcccagc gcatccgccg ctttctccag atggtgtgcc cggccggggc   3360

aggcgccctg gagcctggcg ccccaggcag ctgctacctg gatgcagggc tgcggcggcg   3420

cctgcgggag gagtggggcg tgagctgctg gaccctgctc caggcccccg gagaggccgt   3480

gctggtgcct gcaggggctc cccaccaggt gcagggcctg gtgagcacag tcagcgtcac   3540

tcagcacttc ctctcccctg agacctctgc cctctctgct cagctctgcc accagggacc   3600

cagccttccc cctgactgcc acctgcttta tgcccagatg gactgggctg tgttccaagc   3660

agtgaaggtg gccgtgggga cattacagga ggccaaatag agggatgcta ggtgtctggg   3720

atcggggtgg ggacaggtag accaggtgct cagcccaggc acaacttcag caggggatgg   3780

cgctagggga cttggggatt tctggtcaac cccacaagca ccactctggg cacaagcagg   3840

gcactctgtt cccctccccc ttaagccaac aaccacagtg ccaccaagct cacacctgtc   3900

cttctcaggc tggcatctcc cccaccctgt gccccttttc atggtaccag gcccgcactg   3960

ggggcaattg acttcctcca atccccactc ctccgagacc caggagacaa acagcccttc   4020

cttggggaaa cttgggaatc attctggctt aaacaacacc tcctcctgct gctcactccc   4080

gctgagccca ctctactgcc ccagctccgt ttctaccacc gcatcctcac tgggctcact   4140

gcaggcatgc tgaacaaggg gcctccaacc ttctgccctc ctgccaaaag atctggggag   4200

tgtgaggaga gggtggcatc aggagctgct caggcttggc ggagggagcg gcatgggcga   4260

tgtcactcag ccccttcccg gtccgcccgc ttccctcctt catgatttcc attaaagtct   4320

gttgttttgt gactgctgcc agtgtggttg gccctgcccc tgcaggccac atggtccagg   4380

gagggagggg gacatggaaa tctgccttag agacaaatgg agtagggcag cccggagctg   4440

gggcccaagg gacaggacac cactgcctgc tcttcgtctg gggcctgggg ccttgcctcc   4500

cactgaggag actttgggtg gggtgggggg ctgtccccca aagatgctcc tgagtgcaag   4560

agcaggcaag gcagagtcct ggggcacagc cacgaggtga cctccctgtg cagagactcc   4620

cgagccctac tccacccagc aagctccagt ccgccccatc tctcccgtct accctgacct   4680

ggagatccag aagtatggcc cagaagagcc cttgccccgc ctgtctgccc ttggtggcag   4740

tggccatggc cgacgccagg cccagccacc ctgggactga gcctgactgc ttcagacagc   4800

cgacccctcc ttgtccccgc tccacgcccg cagcctcctg gtggcgctcc gccctctccc   4860

gcttcctttg tgtatctcag ccctacaaag aaaaacactc ccactcttgt catacctaat   4920

tgttcctgct gtggtttggg gaattttttt tattaaataa agttttttat tataagggta   4980

a                                                                   4981


<210>  2224
<211>  1189
<212>  PRT
<213>  Homosapiens

<400>  2224

Met Glu Ser Thr Pro Ser Phe Leu Lys Gly Thr Pro Thr Trp Glu Lys 
1               5                   10                  15      


Thr Ala Pro Glu Asn Gly Ile Val Arg Gln Glu Pro Gly Ser Pro Pro 
            20                  25                  30          


Arg Asp Gly Leu His His Gly Pro Leu Cys Leu Gly Glu Pro Ala Pro 
        35                  40                  45              


Phe Trp Arg Gly Val Leu Ser Thr Pro Asp Ser Trp Leu Pro Pro Gly 
    50                  55                  60                  


Phe Pro Gln Gly Pro Lys Asp Met Leu Pro Leu Val Glu Gly Glu Gly 
65                  70                  75                  80  


Pro Gln Asn Gly Glu Arg Lys Val Asn Trp Leu Gly Ser Lys Glu Gly 
                85                  90                  95      


Leu Arg Trp Lys Glu Ala Met Leu Thr His Pro Leu Ala Phe Cys Gly 
            100                 105                 110         


Pro Ala Cys Pro Pro Arg Cys Gly Pro Leu Met Pro Glu His Ser Gly 
        115                 120                 125             


Gly His Leu Lys Ser Asp Pro Val Ala Phe Arg Pro Trp His Cys Pro 
    130                 135                 140                 


Phe Leu Leu Glu Thr Lys Ile Leu Glu Arg Ala Pro Phe Trp Val Pro 
145                 150                 155                 160 


Thr Cys Leu Pro Pro Tyr Leu Val Ser Gly Leu Pro Pro Glu His Pro 
                165                 170                 175     


Cys Asp Trp Pro Leu Thr Pro His Pro Trp Val Tyr Ser Gly Gly Gln 
            180                 185                 190         


Pro Lys Val Pro Ser Ala Phe Ser Leu Gly Ser Lys Gly Phe Tyr Tyr 
        195                 200                 205             


Lys Asp Pro Ser Ile Pro Arg Leu Ala Lys Glu Pro Leu Ala Ala Ala 
    210                 215                 220                 


Glu Pro Gly Leu Phe Gly Leu Asn Ser Gly Gly His Leu Gln Arg Ala 
225                 230                 235                 240 


Gly Glu Ala Glu Arg Pro Ser Leu His Gln Arg Asp Gly Glu Met Gly 
                245                 250                 255     


Ala Gly Arg Gln Gln Asn Pro Cys Pro Leu Phe Leu Gly Gln Pro Asp 
            260                 265                 270         


Thr Val Pro Trp Thr Ser Trp Pro Ala Cys Pro Pro Gly Leu Val His 
        275                 280                 285             


Thr Leu Gly Asn Val Trp Ala Gly Pro Gly Asp Gly Asn Leu Gly Tyr 
    290                 295                 300                 


Gln Leu Gly Pro Pro Ala Thr Pro Arg Cys Pro Ser Pro Glu Pro Pro 
305                 310                 315                 320 


Val Thr Gln Arg Gly Cys Cys Ser Ser Tyr Pro Pro Thr Lys Gly Gly 
                325                 330                 335     


Gly Leu Gly Pro Cys Gly Lys Cys Gln Glu Gly Leu Glu Gly Gly Ala 
            340                 345                 350         


Ser Gly Ala Ser Glu Pro Ser Glu Glu Val Asn Lys Ala Ser Gly Pro 
        355                 360                 365             


Arg Ala Cys Pro Pro Ser His His Thr Lys Leu Lys Lys Thr Trp Leu 
    370                 375                 380                 


Thr Arg His Ser Glu Gln Phe Glu Cys Pro Arg Gly Cys Pro Glu Val 
385                 390                 395                 400 


Glu Glu Arg Pro Val Ala Arg Leu Arg Ala Leu Lys Arg Ala Gly Ser 
                405                 410                 415     


Pro Glu Val Gln Gly Ala Met Gly Ser Pro Ala Pro Lys Arg Pro Pro 
            420                 425                 430         


Asp Pro Phe Pro Gly Thr Ala Glu Gln Gly Ala Gly Gly Trp Gln Glu 
        435                 440                 445             


Val Arg Asp Thr Ser Ile Gly Asn Lys Asp Val Asp Ser Gly Gln His 
    450                 455                 460                 


Asp Glu Gln Lys Gly Pro Gln Asp Gly Gln Ala Ser Leu Gln Asp Pro 
465                 470                 475                 480 


Gly Leu Gln Asp Ile Pro Cys Leu Ala Leu Pro Ala Lys Leu Ala Gln 
                485                 490                 495     


Cys Gln Ser Cys Ala Gln Ala Ala Gly Glu Gly Gly Gly His Ala Cys 
            500                 505                 510         


His Ser Gln Gln Val Arg Arg Ser Pro Leu Gly Gly Glu Leu Gln Gln 
        515                 520                 525             


Glu Glu Asp Thr Ala Thr Asn Ser Ser Ser Glu Glu Gly Pro Gly Ser 
    530                 535                 540                 


Gly Pro Asp Ser Arg Leu Ser Thr Gly Leu Ala Lys His Leu Leu Ser 
545                 550                 555                 560 


Gly Leu Gly Asp Arg Leu Cys Arg Leu Leu Arg Arg Glu Arg Glu Ala 
                565                 570                 575     


Leu Ala Trp Ala Gln Arg Glu Gly Gln Gly Pro Ala Val Thr Glu Asp 
            580                 585                 590         


Ser Pro Gly Ile Pro Arg Cys Cys Ser Arg Cys His His Gly Leu Phe 
        595                 600                 605             


Asn Thr His Trp Arg Cys Pro Arg Cys Ser His Arg Leu Cys Val Ala 
    610                 615                 620                 


Cys Gly Arg Val Ala Gly Thr Gly Arg Ala Arg Glu Lys Ala Gly Phe 
625                 630                 635                 640 


Gln Glu Gln Ser Ala Glu Glu Cys Thr Gln Glu Ala Gly His Ala Ala 
                645                 650                 655     


Cys Ser Leu Met Leu Thr Gln Phe Val Ser Ser Gln Ala Leu Ala Glu 
            660                 665                 670         


Leu Ser Thr Ala Met His Gln Val Trp Val Lys Phe Asp Ile Arg Gly 
        675                 680                 685             


His Cys Pro Cys Gln Ala Asp Ala Arg Val Trp Ala Pro Gly Asp Ala 
    690                 695                 700                 


Gly Gln Gln Lys Glu Ser Thr Gln Lys Thr Pro Pro Thr Pro Gln Pro 
705                 710                 715                 720 


Ser Cys Asn Gly Asp Thr His Arg Thr Lys Ser Ile Lys Glu Glu Thr 
                725                 730                 735     


Pro Asp Ser Ala Glu Thr Pro Ala Glu Asp Arg Ala Gly Arg Gly Pro 
            740                 745                 750         


Leu Pro Cys Pro Ser Leu Cys Glu Leu Leu Ala Ser Thr Ala Val Lys 
        755                 760                 765             


Leu Cys Leu Gly His Glu Arg Ile His Met Ala Phe Ala Pro Val Thr 
    770                 775                 780                 


Pro Ala Leu Pro Ser Asp Asp Arg Ile Thr Asn Ile Leu Asp Ser Ile 
785                 790                 795                 800 


Ile Ala Gln Val Val Glu Arg Lys Ile Gln Glu Lys Ala Leu Gly Pro 
                805                 810                 815     


Gly Leu Arg Ala Gly Pro Gly Leu Arg Lys Gly Leu Gly Leu Pro Leu 
            820                 825                 830         


Ser Pro Val Arg Pro Arg Leu Pro Pro Pro Gly Ala Leu Leu Trp Leu 
        835                 840                 845             


Gln Glu Pro Gln Pro Cys Pro Arg Arg Gly Phe His Leu Phe Gln Glu 
    850                 855                 860                 


His Trp Arg Gln Gly Gln Pro Val Leu Val Ser Gly Ile Gln Arg Thr 
865                 870                 875                 880 


Leu Gln Gly Asn Leu Trp Gly Thr Glu Ala Leu Gly Ala Leu Gly Gly 
                885                 890                 895     


Gln Val Gln Ala Leu Ser Pro Leu Gly Pro Pro Gln Pro Ser Ser Leu 
            900                 905                 910         


Gly Ser Thr Thr Phe Trp Glu Gly Phe Ser Trp Pro Glu Leu Arg Pro 
        915                 920                 925             


Lys Ser Asp Glu Gly Ser Val Leu Leu Leu His Arg Ala Leu Gly Asp 
    930                 935                 940                 


Glu Asp Thr Ser Arg Val Glu Asn Leu Ala Ala Ser Leu Pro Leu Pro 
945                 950                 955                 960 


Glu Tyr Cys Ala Leu His Gly Lys Leu Asn Leu Ala Ser Tyr Leu Pro 
                965                 970                 975     


Pro Gly Leu Ala Leu Arg Pro Leu Glu Pro Gln Leu Trp Ala Ala Tyr 
            980                 985                 990         


Gly Val Ser Pro His Arg Gly His  Leu Gly Thr Lys Asn  Leu Cys Val 
        995                 1000                 1005             


Glu Val  Ala Asp Leu Val Ser  Ile Leu Val His Ala  Asp Thr Pro 
    1010                 1015                 1020             


Leu Pro  Ala Trp His Arg Ala  Gln Lys Asp Phe Leu  Ser Gly Leu 
    1025                 1030                 1035             


Asp Gly  Glu Gly Leu Trp Ser  Pro Gly Ser Gln Val  Ser Thr Val 
    1040                 1045                 1050             


Trp His  Val Phe Arg Ala Gln  Asp Ala Gln Arg Ile  Arg Arg Phe 
    1055                 1060                 1065             


Leu Gln  Met Val Cys Pro Ala  Gly Ala Gly Ala Leu  Glu Pro Gly 
    1070                 1075                 1080             


Ala Pro  Gly Ser Cys Tyr Leu  Asp Ala Gly Leu Arg  Arg Arg Leu 
    1085                 1090                 1095             


Arg Glu  Glu Trp Gly Val Ser  Cys Trp Thr Leu Leu  Gln Ala Pro 
    1100                 1105                 1110             


Gly Glu  Ala Val Leu Val Pro  Ala Gly Ala Pro His  Gln Val Gln 
    1115                 1120                 1125             


Gly Leu  Val Ser Thr Val Ser  Val Thr Gln His Phe  Leu Ser Pro 
    1130                 1135                 1140             


Glu Thr  Ser Ala Leu Ser Ala  Gln Leu Cys His Gln  Gly Pro Ser 
    1145                 1150                 1155             


Leu Pro  Pro Asp Cys His Leu  Leu Tyr Ala Gln Met  Asp Trp Ala 
    1160                 1165                 1170             


Val Phe  Gln Ala Val Lys Val  Ala Val Gly Thr Leu  Gln Glu Ala 
    1175                 1180                 1185             


Lys 
    


<210>  2225
<211>  4816
<212>  DNA
<213>  Homosapiens

<400>  2225
ggccccggag ctggcccatg gggagcaggc gcccggtgcc ggccacgacg accgccaccg     60

cccgcgccgc gaccggccgg tgaagcccag ggacccccct ctgggagagc cccatgaggg    120

caggagagtg atggagagta cgcccagctt cctgaagggc accccaacct gggagaagac    180

ggccccagag aacggcatcg tgagacagga gcccggcagc ccgcctcgag atggactgca    240

ccatgggccg ctgtgcctgg gagagcctgc tcccttttgg aggggcgtcc tgagcacccc    300

agactcctgg cttccccctg gcttccccca gggccccaag gacatgctcc cacttgtgga    360

gggcgagggc ccccagaatg gggagaggaa ggtcaactgg ctgggcagca aagagggact    420

gcgctggaag gaggccatgc ttacccatcc gctggcattc tgcgggccag cgtgcccacc    480

tcgctgtggc cccctgatgc ctgagcatag tggtggccat ctcaagagtg accctgtggc    540

cttccggccc tggcactgcc ctttccttct ggagaccaag atcctggagc gagctccctt    600

ctgggtgccc acctgcttgc caccctacct agtgtctggc ctgcccccag agcatccatg    660

tgactggccc ctgaccccgc acccctgggt atactccggg ggccagccca aagtgccctc    720

tgccttcagc ttaggcagca agggctttta ctacaaggat ccgagcattc ccaggttggc    780

aaaggagccc ttggcagctg cggaacctgg gttgtttggc ttaaactctg gtgggcacct    840

gcagagagcc ggggaggccg aacgcccttc actgcaccag agggatggag agatgggagc    900

tggccggcag cagaatcctt gcccgctctt cctggggcag ccagacactg tgccctggac    960

ctcctggccc gcttgtcccc caggccttgt tcatactctt ggcaacgtct gggctgggcc   1020

aggcgatggg aaccttgggt accagctggg gccaccagca acaccaaggt gcccctctcc   1080

tgagccgcct gtcacccagc ggggctgctg ttcatcctac ccacccacta aaggtggggg   1140

tcttggccct tgtgggaagt gccaggaggg cctggagggg ggtgccagtg gagccagcga   1200

acccagcgag gaagtgaaca aggcctctgg ccccagggcc tgtcccccca gccaccacac   1260

caagctgaag aagacatggc tcacacggca ctcggagcag tttgaatgtc cacgcggctg   1320

ccctgaggtc gaggagaggc cggttgctcg gctccgggcc ctcaaaaggg caggcagccc   1380

cgaggtccag ggagcaatgg gcagtccagc ccccaagcgg ccaccggacc cttttccagg   1440

cactgcagaa cagggggctg ggggttggca ggaggtgcgg gacacatcga tagggaacaa   1500

ggatgtggac tcgggacagc atgatgagca gaaaggaccc caagatggcc aggccagtct   1560

ccaggacccg ggacttcagg acataccatg cctggctctc cctgcaaaac tggctcaatg   1620

ccaaagttgt gcccaggcag ctggagaggg aggagggcac gcctgccact ctcagcaagt   1680

gcggagatcg cctctgggag gggagctgca gcaggaggaa gacacagcca ccaactccag   1740

ctctgaggaa ggcccagggt ccggccctga cagccggctc agcacaggcc tcgccaagca   1800

cctgctcagt ggtttggggg accgactgtg ccgcctgctg cggagggagc gggaggccct   1860

ggcttgggcc cagcgggaag gccaagggcc agccgtgaca gaggacagcc caggcattcc   1920

acgctgctgc agccgttgcc accatggact cttcaacacc cactggcgat gtccccgctg   1980

cagccaccgg ctgtgtgtgg cctgtggtcg tgtggcaggc actgggcggg ccagggagaa   2040

agcaggcttt caggagcagt ccgcggagga gtgcacgcag gaggccgggc acgctgcctg   2100

ttccctgatg ctgacccagt ttgtctccag ccaggctttg gcagagctga gcactgcaat   2160

gcaccaggtc tgggtcaagt ttgatatccg ggggcactgc ccctgccaag ctgatgcccg   2220

ggtatgggcc cccggggatg caggccagca gaaggaatca acacagaaaa cgcccccaac   2280

tccacaacct tcctgcaatg gcgacaccca caggaccaag agcatcaaag aggagacccc   2340

cgattccgct gagaccccag cagaggaccg tgctggccga gggcccctgc cttgtccttc   2400

tctctgcgaa ctgctggctt ctaccgcggt caaactctgc ttgggccatg agcgaataca   2460

catggccttc gcccccgtca ctccggccct gcccagtgat gaccgcatca ccaacatcct   2520

ggacagcatt atcgcacagg tggtggaacg gaagatccag gagaaagccc tggggccggg   2580

gcttcgagct ggcccgggtc tgcgcaaggg cctgggcctg cccctctctc cagtgcggcc   2640

ccggctgcct cccccagggg ctttgctgtg gctgcaggag ccccagcctt gccctcggcg   2700

tggcttccac ctcttccagg agcactggag gcagggccag cctgtgttgg tgtcagggat   2760

ccaaaggaca ttgcagggca acctgtgggg gacagaagct cttggggcac ttggaggcca   2820

ggtgcaggcg ctgagccccc tcggacctcc ccagcccagc agcctgggca gcacaacatt   2880

ctgggagggc ttctcctggc ctgagcttcg cccaaagtca gacgagggct ctgtcctcct   2940

gctgcaccga gctttggggg atgaggacac cagcagggtg gagaacctag ctgccagtct   3000

gccacttccg gagtactgcg ccctccatgg aaaactcaac ctggcttcct acctcccacc   3060

gggccttgcc ctgcgtccac tggagcccca gctctgggca gcctatggtg tgagcccgca   3120

ccggggacac ctggggacca agaacctctg tgtggaggtg gccgacctgg tcagcatcct   3180

ggtgcatgcc gacacaccac tgcctgcctg gcaccgggca cagaaagact tcctttcagg   3240

cctggacggg gaggggctct ggtctccggg cagccaggtc agcactgtgt ggcacgtgtt   3300

ccgggcacag gacgcccagc gcatccgccg ctttctccag atggtgcagg gcctggtgag   3360

cacagtcagc gtcactcagc acttcctctc ccctgagacc tctgccctct ctgctcagct   3420

ctgccaccag ggacccagcc ttccccctga ctgccacctg ctttatgccc agatggactg   3480

ggctgtgttc caagcagtga aggtggccgt ggggacatta caggaggcca aatagaggga   3540

tgctaggtgt ctgggatcgg ggtggggaca ggtagaccag gtgctcagcc caggcacaac   3600

ttcagcaggg gatggcgcta ggggacttgg ggatttctgg tcaaccccac aagcaccact   3660

ctgggcacaa gcagggcact ctgttcccct cccccttaag ccaacaacca cagtgccacc   3720

aagctcacac ctgtccttct caggctggca tctcccccac cctgtgcccc ttttcatggt   3780

accaggcccg cactgggggc aattgacttc ctccaatccc cactcctccg agacccagga   3840

gacaaacagc ccttccttgg ggaaacttgg gaatcattct ggcttaaaca acacctcctc   3900

ctgctgctca ctcccgctga gcccactcta ctgccccagc tccgtttcta ccaccgcatc   3960

ctcactgggc tcactgcagg catgctgaac aaggggcctc caaccttctg ccctcctgcc   4020

aaaagatctg gggagtgtga ggagagggtg gcatcaggag ctgctcaggc ttggcggagg   4080

gagcggcatg ggcgatgtca ctcagcccct tcccggtccg cccgcttccc tccttcatga   4140

tttccattaa agtctgttgt tttgtgactg ctgccagtgt ggttggccct gcccctgcag   4200

gccacatggt ccagggaggg agggggacat ggaaatctgc cttagagaca aatggagtag   4260

ggcagcccgg agctggggcc caagggacag gacaccactg cctgctcttc gtctggggcc   4320

tggggccttg cctcccactg aggagacttt gggtggggtg gggggctgtc ccccaaagat   4380

gctcctgagt gcaagagcag gcaaggcaga gtcctggggc acagccacga ggtgacctcc   4440

ctgtgcagag actcccgagc cctactccac ccagcaagct ccagtccgcc ccatctctcc   4500

cgtctaccct gacctggaga tccagaagta tggcccagaa gagcccttgc cccgcctgtc   4560

tgcccttggt ggcagtggcc atggccgacg ccaggcccag ccaccctggg actgagcctg   4620

actgcttcag acagccgacc cctccttgtc cccgctccac gcccgcagcc tcctggtggc   4680

gctccgccct ctcccgcttc ctttgtgtat ctcagcccta caaagaaaaa cactcccact   4740

cttgtcatac ctaattgttc ctgctgtggt ttggggaatt ttttttatta aataaagttt   4800

tttattataa gggtaa                                                   4816


<210>  2226
<211>  1134
<212>  PRT
<213>  Homosapiens

<400>  2226

Met Glu Ser Thr Pro Ser Phe Leu Lys Gly Thr Pro Thr Trp Glu Lys 
1               5                   10                  15      


Thr Ala Pro Glu Asn Gly Ile Val Arg Gln Glu Pro Gly Ser Pro Pro 
            20                  25                  30          


Arg Asp Gly Leu His His Gly Pro Leu Cys Leu Gly Glu Pro Ala Pro 
        35                  40                  45              


Phe Trp Arg Gly Val Leu Ser Thr Pro Asp Ser Trp Leu Pro Pro Gly 
    50                  55                  60                  


Phe Pro Gln Gly Pro Lys Asp Met Leu Pro Leu Val Glu Gly Glu Gly 
65                  70                  75                  80  


Pro Gln Asn Gly Glu Arg Lys Val Asn Trp Leu Gly Ser Lys Glu Gly 
                85                  90                  95      


Leu Arg Trp Lys Glu Ala Met Leu Thr His Pro Leu Ala Phe Cys Gly 
            100                 105                 110         


Pro Ala Cys Pro Pro Arg Cys Gly Pro Leu Met Pro Glu His Ser Gly 
        115                 120                 125             


Gly His Leu Lys Ser Asp Pro Val Ala Phe Arg Pro Trp His Cys Pro 
    130                 135                 140                 


Phe Leu Leu Glu Thr Lys Ile Leu Glu Arg Ala Pro Phe Trp Val Pro 
145                 150                 155                 160 


Thr Cys Leu Pro Pro Tyr Leu Val Ser Gly Leu Pro Pro Glu His Pro 
                165                 170                 175     


Cys Asp Trp Pro Leu Thr Pro His Pro Trp Val Tyr Ser Gly Gly Gln 
            180                 185                 190         


Pro Lys Val Pro Ser Ala Phe Ser Leu Gly Ser Lys Gly Phe Tyr Tyr 
        195                 200                 205             


Lys Asp Pro Ser Ile Pro Arg Leu Ala Lys Glu Pro Leu Ala Ala Ala 
    210                 215                 220                 


Glu Pro Gly Leu Phe Gly Leu Asn Ser Gly Gly His Leu Gln Arg Ala 
225                 230                 235                 240 


Gly Glu Ala Glu Arg Pro Ser Leu His Gln Arg Asp Gly Glu Met Gly 
                245                 250                 255     


Ala Gly Arg Gln Gln Asn Pro Cys Pro Leu Phe Leu Gly Gln Pro Asp 
            260                 265                 270         


Thr Val Pro Trp Thr Ser Trp Pro Ala Cys Pro Pro Gly Leu Val His 
        275                 280                 285             


Thr Leu Gly Asn Val Trp Ala Gly Pro Gly Asp Gly Asn Leu Gly Tyr 
    290                 295                 300                 


Gln Leu Gly Pro Pro Ala Thr Pro Arg Cys Pro Ser Pro Glu Pro Pro 
305                 310                 315                 320 


Val Thr Gln Arg Gly Cys Cys Ser Ser Tyr Pro Pro Thr Lys Gly Gly 
                325                 330                 335     


Gly Leu Gly Pro Cys Gly Lys Cys Gln Glu Gly Leu Glu Gly Gly Ala 
            340                 345                 350         


Ser Gly Ala Ser Glu Pro Ser Glu Glu Val Asn Lys Ala Ser Gly Pro 
        355                 360                 365             


Arg Ala Cys Pro Pro Ser His His Thr Lys Leu Lys Lys Thr Trp Leu 
    370                 375                 380                 


Thr Arg His Ser Glu Gln Phe Glu Cys Pro Arg Gly Cys Pro Glu Val 
385                 390                 395                 400 


Glu Glu Arg Pro Val Ala Arg Leu Arg Ala Leu Lys Arg Ala Gly Ser 
                405                 410                 415     


Pro Glu Val Gln Gly Ala Met Gly Ser Pro Ala Pro Lys Arg Pro Pro 
            420                 425                 430         


Asp Pro Phe Pro Gly Thr Ala Glu Gln Gly Ala Gly Gly Trp Gln Glu 
        435                 440                 445             


Val Arg Asp Thr Ser Ile Gly Asn Lys Asp Val Asp Ser Gly Gln His 
    450                 455                 460                 


Asp Glu Gln Lys Gly Pro Gln Asp Gly Gln Ala Ser Leu Gln Asp Pro 
465                 470                 475                 480 


Gly Leu Gln Asp Ile Pro Cys Leu Ala Leu Pro Ala Lys Leu Ala Gln 
                485                 490                 495     


Cys Gln Ser Cys Ala Gln Ala Ala Gly Glu Gly Gly Gly His Ala Cys 
            500                 505                 510         


His Ser Gln Gln Val Arg Arg Ser Pro Leu Gly Gly Glu Leu Gln Gln 
        515                 520                 525             


Glu Glu Asp Thr Ala Thr Asn Ser Ser Ser Glu Glu Gly Pro Gly Ser 
    530                 535                 540                 


Gly Pro Asp Ser Arg Leu Ser Thr Gly Leu Ala Lys His Leu Leu Ser 
545                 550                 555                 560 


Gly Leu Gly Asp Arg Leu Cys Arg Leu Leu Arg Arg Glu Arg Glu Ala 
                565                 570                 575     


Leu Ala Trp Ala Gln Arg Glu Gly Gln Gly Pro Ala Val Thr Glu Asp 
            580                 585                 590         


Ser Pro Gly Ile Pro Arg Cys Cys Ser Arg Cys His His Gly Leu Phe 
        595                 600                 605             


Asn Thr His Trp Arg Cys Pro Arg Cys Ser His Arg Leu Cys Val Ala 
    610                 615                 620                 


Cys Gly Arg Val Ala Gly Thr Gly Arg Ala Arg Glu Lys Ala Gly Phe 
625                 630                 635                 640 


Gln Glu Gln Ser Ala Glu Glu Cys Thr Gln Glu Ala Gly His Ala Ala 
                645                 650                 655     


Cys Ser Leu Met Leu Thr Gln Phe Val Ser Ser Gln Ala Leu Ala Glu 
            660                 665                 670         


Leu Ser Thr Ala Met His Gln Val Trp Val Lys Phe Asp Ile Arg Gly 
        675                 680                 685             


His Cys Pro Cys Gln Ala Asp Ala Arg Val Trp Ala Pro Gly Asp Ala 
    690                 695                 700                 


Gly Gln Gln Lys Glu Ser Thr Gln Lys Thr Pro Pro Thr Pro Gln Pro 
705                 710                 715                 720 


Ser Cys Asn Gly Asp Thr His Arg Thr Lys Ser Ile Lys Glu Glu Thr 
                725                 730                 735     


Pro Asp Ser Ala Glu Thr Pro Ala Glu Asp Arg Ala Gly Arg Gly Pro 
            740                 745                 750         


Leu Pro Cys Pro Ser Leu Cys Glu Leu Leu Ala Ser Thr Ala Val Lys 
        755                 760                 765             


Leu Cys Leu Gly His Glu Arg Ile His Met Ala Phe Ala Pro Val Thr 
    770                 775                 780                 


Pro Ala Leu Pro Ser Asp Asp Arg Ile Thr Asn Ile Leu Asp Ser Ile 
785                 790                 795                 800 


Ile Ala Gln Val Val Glu Arg Lys Ile Gln Glu Lys Ala Leu Gly Pro 
                805                 810                 815     


Gly Leu Arg Ala Gly Pro Gly Leu Arg Lys Gly Leu Gly Leu Pro Leu 
            820                 825                 830         


Ser Pro Val Arg Pro Arg Leu Pro Pro Pro Gly Ala Leu Leu Trp Leu 
        835                 840                 845             


Gln Glu Pro Gln Pro Cys Pro Arg Arg Gly Phe His Leu Phe Gln Glu 
    850                 855                 860                 


His Trp Arg Gln Gly Gln Pro Val Leu Val Ser Gly Ile Gln Arg Thr 
865                 870                 875                 880 


Leu Gln Gly Asn Leu Trp Gly Thr Glu Ala Leu Gly Ala Leu Gly Gly 
                885                 890                 895     


Gln Val Gln Ala Leu Ser Pro Leu Gly Pro Pro Gln Pro Ser Ser Leu 
            900                 905                 910         


Gly Ser Thr Thr Phe Trp Glu Gly Phe Ser Trp Pro Glu Leu Arg Pro 
        915                 920                 925             


Lys Ser Asp Glu Gly Ser Val Leu Leu Leu His Arg Ala Leu Gly Asp 
    930                 935                 940                 


Glu Asp Thr Ser Arg Val Glu Asn Leu Ala Ala Ser Leu Pro Leu Pro 
945                 950                 955                 960 


Glu Tyr Cys Ala Leu His Gly Lys Leu Asn Leu Ala Ser Tyr Leu Pro 
                965                 970                 975     


Pro Gly Leu Ala Leu Arg Pro Leu Glu Pro Gln Leu Trp Ala Ala Tyr 
            980                 985                 990         


Gly Val Ser Pro His Arg Gly His  Leu Gly Thr Lys Asn  Leu Cys Val 
        995                 1000                 1005             


Glu Val  Ala Asp Leu Val Ser  Ile Leu Val His Ala  Asp Thr Pro 
    1010                 1015                 1020             


Leu Pro  Ala Trp His Arg Ala  Gln Lys Asp Phe Leu  Ser Gly Leu 
    1025                 1030                 1035             


Asp Gly  Glu Gly Leu Trp Ser  Pro Gly Ser Gln Val  Ser Thr Val 
    1040                 1045                 1050             


Trp His  Val Phe Arg Ala Gln  Asp Ala Gln Arg Ile  Arg Arg Phe 
    1055                 1060                 1065             


Leu Gln  Met Val Gln Gly Leu  Val Ser Thr Val Ser  Val Thr Gln 
    1070                 1075                 1080             


His Phe  Leu Ser Pro Glu Thr  Ser Ala Leu Ser Ala  Gln Leu Cys 
    1085                 1090                 1095             


His Gln  Gly Pro Ser Leu Pro  Pro Asp Cys His Leu  Leu Tyr Ala 
    1100                 1105                 1110             


Gln Met  Asp Trp Ala Val Phe  Gln Ala Val Lys Val  Ala Val Gly 
    1115                 1120                 1125             


Thr Leu  Gln Glu Ala Lys 
    1130                 


<210>  2227
<211>  1731
<212>  DNA
<213>  Homosapiens

<400>  2227
gcaagccgga gccctggggt tgggcagcac tcggttccgt gcaactttca agtgagttgc     60

gaactccgcc ctgtaggccg gtgctggtgg cccggcgcgc tggaaccgcg gcgacccgct    120

ccagcgcggg accagcagca agggccgagc gccaggttct ccgcggcaga aagggcgggt    180

gggagctgta actgccccgg ccgcggggcg cgcccgctcc caagtcggct tcctccccgc    240

cggggccgct ttgcctcggg tctccccatt ctccaggtcc cctgaactgc acagtcggag    300

gccgtgggcg gcgggctctg cctccgccga gggacagccg gatcgcccct ctgcttcccg    360

caactgccct gatcaccccc cgtcccagcc cttgagtgaa cgtccttctg agcggcttcc    420

tggggtcctc cccacgtccc aaaggccggc aagatggtgt cctggatgat ctgtcgcctg    480

gtggtgctgg tgtttgggat gctgtgtcca gcttatgctt cctataaggc tgtgaagacc    540

aagaacattc gtgaatatgt gcggtggatg atgtactgga ttgtttttgc actcttcatg    600

gcagcagaga tcgttacaga catttttatc tcctggttcc ctttctacta tgagatcaag    660

atggccttcg tgctgtggct gctctcaccc tacaccaagg gcgccagcct gctttaccgc    720

aagtttgtcc acccgtccct gtcccgccat gagaaggaga tcgacgcgta catcgtgcag    780

gccaaggagc gcagctacga gaccgtgctc agcttcggga agcggggcct caacattgcc    840

gcctccgctg ctgtgcaggc tgccaccaag agtcaggggg cgctggccgg caggctgcgg    900

agcttctcca tgcaggacct gcgctccatc tctgacgcac ctgcccctgc ctaccatgac    960

cccctctacc tggaggacca ggtgtcccac cggaggccac ccattgggta ccgggccggg   1020

ggcctgcagg acagcgacac cgaggatgag tgttggtcag atactgaggc agtcccccgg   1080

gcgccagccc ggccccgaga gaagccccta atccgcagcc agagcctgcg tgtggtcaag   1140

aggaagccac cggtgcggga gggcacctcg cgctccctga aggttcggac gaggaaaaag   1200

actgtgccct cagacgtgga cagctagggt ctgctgcatc tgcccccttc ttacctcgtg   1260

ccctgcaggg ctccagggct atttggaggg accttgggct gcacatctgg cctgcctgca   1320

ccagctgcct gggccccacc ctcctgactc ctgctgatgg ttaagggccg ggagcagatg   1380

ctgccaaggc cacatgcagg gatgcaccca caatgtacca aagcaggctg ggcccagggt   1440

tctatttatt gccttgctct gccctctccc ttccccggtt gtgggacaag agccctccct   1500

gaacccctgc aaccctccct gaacccctgc aaatgaaacc aaacgtccac ctgggtgtgt   1560

tcattccttc ctgtccttca aagtacttga tagcctttca taaggcctgg cacatgtgtc   1620

ctggttgtgt gtgtgtgtgt tggtgagtga ggtcaggttt gcgagtgttt tgataaataa   1680

atacataaag gggcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a            1731


<210>  2228
<211>  257
<212>  PRT
<213>  Homosapiens

<400>  2228

Met Val Ser Trp Met Ile Cys Arg Leu Val Val Leu Val Phe Gly Met 
1               5                   10                  15      


Leu Cys Pro Ala Tyr Ala Ser Tyr Lys Ala Val Lys Thr Lys Asn Ile 
            20                  25                  30          


Arg Glu Tyr Val Arg Trp Met Met Tyr Trp Ile Val Phe Ala Leu Phe 
        35                  40                  45              


Met Ala Ala Glu Ile Val Thr Asp Ile Phe Ile Ser Trp Phe Pro Phe 
    50                  55                  60                  


Tyr Tyr Glu Ile Lys Met Ala Phe Val Leu Trp Leu Leu Ser Pro Tyr 
65                  70                  75                  80  


Thr Lys Gly Ala Ser Leu Leu Tyr Arg Lys Phe Val His Pro Ser Leu 
                85                  90                  95      


Ser Arg His Glu Lys Glu Ile Asp Ala Tyr Ile Val Gln Ala Lys Glu 
            100                 105                 110         


Arg Ser Tyr Glu Thr Val Leu Ser Phe Gly Lys Arg Gly Leu Asn Ile 
        115                 120                 125             


Ala Ala Ser Ala Ala Val Gln Ala Ala Thr Lys Ser Gln Gly Ala Leu 
    130                 135                 140                 


Ala Gly Arg Leu Arg Ser Phe Ser Met Gln Asp Leu Arg Ser Ile Ser 
145                 150                 155                 160 


Asp Ala Pro Ala Pro Ala Tyr His Asp Pro Leu Tyr Leu Glu Asp Gln 
                165                 170                 175     


Val Ser His Arg Arg Pro Pro Ile Gly Tyr Arg Ala Gly Gly Leu Gln 
            180                 185                 190         


Asp Ser Asp Thr Glu Asp Glu Cys Trp Ser Asp Thr Glu Ala Val Pro 
        195                 200                 205             


Arg Ala Pro Ala Arg Pro Arg Glu Lys Pro Leu Ile Arg Ser Gln Ser 
    210                 215                 220                 


Leu Arg Val Val Lys Arg Lys Pro Pro Val Arg Glu Gly Thr Ser Arg 
225                 230                 235                 240 


Ser Leu Lys Val Arg Thr Arg Lys Lys Thr Val Pro Ser Asp Val Asp 
                245                 250                 255     


Ser 
    


<210>  2229
<211>  3285
<212>  DNA
<213>  Homosapiens

<400>  2229
cgcgcgcccc cgccgcccgc gccgcagtcc gcagccaccc ggcgcggtca gccccggctg     60

cggctccagc tccgcgctcc gctcttctct cccgagccgg atcgcgggag cgagcagggg    120

aggggaccgc agccggcgcc cgagggcagg aggagtccgc aggcgggccc ctggctgcgg    180

tagcagctgc cggtggcagg gaggtgccag cccgcgcggg gtggcccagc cgcgggagcg    240

gtggggcggg ggccgcggcc gccggcccca gggagagatc gcgggcagca tggcggggct    300

gcgggccagg gggggcccgg ggccggggct gctggcgctc tccgcgctcg gcttctgcct    360

catgctgcaa gtcagcgcta agaggccccc caagacgccc ccctgcccgc ccagctgctc    420

ttgcaccagg gacaccgcct tctgcgtgga ctcaaaggcg gtgcccagga acctgccctc    480

ggaggtcatc tccctgaccc tggtgaatgc cgccttctca gagatccagg atggagcgtt    540

ctcccacctc ccgctgctgc agttcttgtt actcaactcc aacaagttta cactgattgg    600

agacaacgcc ttcacaggac tgtcgcacct gcagtatctc ttcattgaga acaatgacat    660

ctgggcacta tccaagttca ccttccgagg actcaagtcc ttgactcacc tctcgctggc    720

caacaataac ctgcagacac tgcccagaga catcttccgg cccctggaca tcctgaatga    780

cttggacctg cggggcaact cactcaactg tgactgcaag gtgaagtggt tggtggagtg    840

gctggcacac accaacacca cggtggcacc catctactgc gccagcccgc cccgcttcca    900

ggagcacaag gtgcaggacc tgccgctgcg ggagttcgat tgcatcacca cagattttgt    960

gttgtaccag accctggcct tcccagcagt gtcggctgag cccttcctct actccagtga   1020

cctctatttg gctctggccc agccaggagt cagtgcctgc accatcctga agtgggacta   1080

tgttgagcgg cagcttcgag actatgatag aatcccagcc ccctctgcag tgcactgcaa   1140

gccgatggtg gtggacagcc agctgtacgt ggtcgtggcc cagctgtttg gcggctctta   1200

catttaccac tgggatccca acaccacgcg cttcaccagg ctgcaagaca ttgacccgca   1260

gcgcgtgcgc aagcctaacg acctagaagc cttccgcatc gacggtgact ggtactttgc   1320

cgtggctgac agctccaagg caggcgccac cagcctctac cgctggcacc agaatggctt   1380

ctactcccac caggcactgc acccctggca ccgtgacacc gacctggagt ttgtggacgg   1440

cgagggcaag ccacggctga ttgtgtccag cagctcccag gcacccgtca tctatcagtg   1500

gagtcgcacc cagaagcagt ttgtggccca gggtgaggtg acccaggtgc ctgatgccca   1560

agctgtgaaa cactttcgtg ccggccgcga cagctacctg tgcctcagcc gctacattgg   1620

cgactccaag atcctgcgct gggagggtac ccgcttctcg gaggtgcagg ccctgccctc   1680

ccggggctcg ctggccctgc agcccttcct tgtgggtggc cgccgctacc tggcactggg   1740

cagtgatttc tccttcaccc agatctacca gtgggatgag ggacgacaga agtttgtacg   1800

gttccaggag ctggctgtgc aggctcctcg ggccttctgc tacatgcctg ctggggacgc   1860

ccagctactc ctggccccca gcttcaaggg acagacgctg gtgtatagac acattgtggt   1920

ggatctcagt gcctaggggg tgccgaggcc tctggtctcc tcagggtggc cactggagga   1980

tgggtggggg cctctgtgag caccacgtat gcctgtgtga agacaagcga ccaacctgca   2040

ttcatgccct tgtatccgca cacgcccagt gtgtacaggc gcaccccgtg gactggccca   2100

ggaggacgtg catcatcact gcaatcagca tgaacaccag gcacccctgg gacacctaac   2160

gcccagttcc cgtgacccca actgcaggcc ccccctactc tgcagccttt cccatgctct   2220

gccccctgtc tcatgcacga gtggtgcggg gtgctgggag cgaggggggc cgcatcctcc   2280

tgtccttgtg cttctccttc tgcccctctg gtctttcctg ttggtgctcc aggcattgtt   2340

tacctgctct tgctccccgc tgtagcccac agccatatct gtcatgcttc cccggggcca   2400

ctcacccctg ccccaccccg tctgcatgct cacatggacg cggacggaca cactcattac   2460

acactcacac gccccgactg cacccggtgt ccatctataa acatgtcagg gcacgtgtgc   2520

atacaagcag attcagcact gcctaccagg ctctcctgtt accttgcctc tctgcttgga   2580

gggggccccc tctgctcacc cccagcgtgc cccccccgga actgataagg atgagaatgg   2640

tggtgccagc ttctgagggc ctgcttggcc tcctgggggc aaagcccctc tgcccgaagc   2700

aataacaaca gcagcagaag caatcccggg gagctgccag gggtgtctgt ctctgttctc   2760

cttggcgttt ccttcatggc cgtgaatccc agctcaccca tggacagaag acctcccctc   2820

atctgaaagc ctttctgcct tccttcctgt agctgtcgct ttctcaggct tggactgtcc   2880

cctggttcac cctgtctttg ggatgtggcc cttgagctgg gcgggctcct tgggtggatt   2940

agagagctgg ccgagctgca agcacctgag ttacctgcga gggtgcccag agtggagctt   3000

ggcctgaggg cgtgttgcag ccctggcccc accagtccac agaggccccc aggagcactg   3060

cctttcagtg gaccgggtgg gggctggtgg gaggggcccc actagctgag cttctgctgc   3120

cctctgctgt ctgctgagat gccaggctag tggagagggc acaccatgtg cccaaatggt   3180

gtgatgctcc ttgtagcagg ataccagggt actggggggc aatgctatga ttaacttgct   3240

tcaaataaaa agttcccgcc ccataaaaaa aaaaaaaaaa aaaaa                   3285


<210>  2230
<211>  548
<212>  PRT
<213>  Homosapiens

<400>  2230

Met Ala Gly Leu Arg Ala Arg Gly Gly Pro Gly Pro Gly Leu Leu Ala 
1               5                   10                  15      


Leu Ser Ala Leu Gly Phe Cys Leu Met Leu Gln Val Ser Ala Lys Arg 
            20                  25                  30          


Pro Pro Lys Thr Pro Pro Cys Pro Pro Ser Cys Ser Cys Thr Arg Asp 
        35                  40                  45              


Thr Ala Phe Cys Val Asp Ser Lys Ala Val Pro Arg Asn Leu Pro Ser 
    50                  55                  60                  


Glu Val Ile Ser Leu Thr Leu Val Asn Ala Ala Phe Ser Glu Ile Gln 
65                  70                  75                  80  


Asp Gly Ala Phe Ser His Leu Pro Leu Leu Gln Phe Leu Leu Leu Asn 
                85                  90                  95      


Ser Asn Lys Phe Thr Leu Ile Gly Asp Asn Ala Phe Thr Gly Leu Ser 
            100                 105                 110         


His Leu Gln Tyr Leu Phe Ile Glu Asn Asn Asp Ile Trp Ala Leu Ser 
        115                 120                 125             


Lys Phe Thr Phe Arg Gly Leu Lys Ser Leu Thr His Leu Ser Leu Ala 
    130                 135                 140                 


Asn Asn Asn Leu Gln Thr Leu Pro Arg Asp Ile Phe Arg Pro Leu Asp 
145                 150                 155                 160 


Ile Leu Asn Asp Leu Asp Leu Arg Gly Asn Ser Leu Asn Cys Asp Cys 
                165                 170                 175     


Lys Val Lys Trp Leu Val Glu Trp Leu Ala His Thr Asn Thr Thr Val 
            180                 185                 190         


Ala Pro Ile Tyr Cys Ala Ser Pro Pro Arg Phe Gln Glu His Lys Val 
        195                 200                 205             


Gln Asp Leu Pro Leu Arg Glu Phe Asp Cys Ile Thr Thr Asp Phe Val 
    210                 215                 220                 


Leu Tyr Gln Thr Leu Ala Phe Pro Ala Val Ser Ala Glu Pro Phe Leu 
225                 230                 235                 240 


Tyr Ser Ser Asp Leu Tyr Leu Ala Leu Ala Gln Pro Gly Val Ser Ala 
                245                 250                 255     


Cys Thr Ile Leu Lys Trp Asp Tyr Val Glu Arg Gln Leu Arg Asp Tyr 
            260                 265                 270         


Asp Arg Ile Pro Ala Pro Ser Ala Val His Cys Lys Pro Met Val Val 
        275                 280                 285             


Asp Ser Gln Leu Tyr Val Val Val Ala Gln Leu Phe Gly Gly Ser Tyr 
    290                 295                 300                 


Ile Tyr His Trp Asp Pro Asn Thr Thr Arg Phe Thr Arg Leu Gln Asp 
305                 310                 315                 320 


Ile Asp Pro Gln Arg Val Arg Lys Pro Asn Asp Leu Glu Ala Phe Arg 
                325                 330                 335     


Ile Asp Gly Asp Trp Tyr Phe Ala Val Ala Asp Ser Ser Lys Ala Gly 
            340                 345                 350         


Ala Thr Ser Leu Tyr Arg Trp His Gln Asn Gly Phe Tyr Ser His Gln 
        355                 360                 365             


Ala Leu His Pro Trp His Arg Asp Thr Asp Leu Glu Phe Val Asp Gly 
    370                 375                 380                 


Glu Gly Lys Pro Arg Leu Ile Val Ser Ser Ser Ser Gln Ala Pro Val 
385                 390                 395                 400 


Ile Tyr Gln Trp Ser Arg Thr Gln Lys Gln Phe Val Ala Gln Gly Glu 
                405                 410                 415     


Val Thr Gln Val Pro Asp Ala Gln Ala Val Lys His Phe Arg Ala Gly 
            420                 425                 430         


Arg Asp Ser Tyr Leu Cys Leu Ser Arg Tyr Ile Gly Asp Ser Lys Ile 
        435                 440                 445             


Leu Arg Trp Glu Gly Thr Arg Phe Ser Glu Val Gln Ala Leu Pro Ser 
    450                 455                 460                 


Arg Gly Ser Leu Ala Leu Gln Pro Phe Leu Val Gly Gly Arg Arg Tyr 
465                 470                 475                 480 


Leu Ala Leu Gly Ser Asp Phe Ser Phe Thr Gln Ile Tyr Gln Trp Asp 
                485                 490                 495     


Glu Gly Arg Gln Lys Phe Val Arg Phe Gln Glu Leu Ala Val Gln Ala 
            500                 505                 510         


Pro Arg Ala Phe Cys Tyr Met Pro Ala Gly Asp Ala Gln Leu Leu Leu 
        515                 520                 525             


Ala Pro Ser Phe Lys Gly Gln Thr Leu Val Tyr Arg His Ile Val Val 
    530                 535                 540                 


Asp Leu Ser Ala 
545             


<210>  2231
<211>  991
<212>  DNA
<213>  Homosapiens

<400>  2231
cttatctcgg cttcgtttct ggagggccag gaacaaacag gcttcaaagc caagggcttg     60

gctggcacac agggggcttg gtccttcacc tctgtcccct ctccctacgg acacatataa    120

gaccctggtc acacctggga gaggaggaga ggagagcata gcacctgcag caagatggat    180

gtgggcagca aagaggtcct gatggagagc ccgccggact actccgcagc tccccggggc    240

cgatttggca ttccctgctg cccagtgcac ctgaaacgcc ttcttatcgt ggtggtggtg    300

gtggtcctca tcgtcgtggt gattgtggga gccctgctca tgggtctcca catgagccag    360

aaacacacgg agatggttct ggagatgagc attggggcgc cggaagccca gcaacgcctg    420

gccctgagtg agcacctggt taccactgcc accttctcca tcggctccac tggcctcgtg    480

gtgtatgact accagcagct gctgatcgcc tacaagccag cccctggcac ctgctgctac    540

atcatgaaga tagctccaga gagcatcccc agtcttgagg ctctcaatag aaaagtccac    600

aacttccaga tggaatgctc tctgcaggcc aagcccgcag tgcctacgtc taagctgggc    660

caggcagagg ggcgagatgc aggctcagca ccctccggag gggacccggc cttcctgggc    720

atggccgtga acaccctgtg tggcgaggtg ccgctctact acatctagga cgcctccggt    780

gagcagggtc agtggaagcc ccaacgggaa aggaaacgcc ccgggcaaag ggtcttttgc    840

agcttttgca gacgggcaag aagctgcttc tgcccacacc gcagggacaa accctggaga    900

aatgggagct tggggagagg atgggagtgg gcagaggtgg cacccagggg cccgggaact    960

cctgccacaa cagaataaag cagcctgatt g                                   991


<210>  2232
<211>  197
<212>  PRT
<213>  Homosapiens

<400>  2232

Met Asp Val Gly Ser Lys Glu Val Leu Met Glu Ser Pro Pro Asp Tyr 
1               5                   10                  15      


Ser Ala Ala Pro Arg Gly Arg Phe Gly Ile Pro Cys Cys Pro Val His 
            20                  25                  30          


Leu Lys Arg Leu Leu Ile Val Val Val Val Val Val Leu Ile Val Val 
        35                  40                  45              


Val Ile Val Gly Ala Leu Leu Met Gly Leu His Met Ser Gln Lys His 
    50                  55                  60                  


Thr Glu Met Val Leu Glu Met Ser Ile Gly Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Arg Leu Ala Leu Ser Glu His Leu Val Thr Thr Ala Thr Phe Ser Ile 
                85                  90                  95      


Gly Ser Thr Gly Leu Val Val Tyr Asp Tyr Gln Gln Leu Leu Ile Ala 
            100                 105                 110         


Tyr Lys Pro Ala Pro Gly Thr Cys Cys Tyr Ile Met Lys Ile Ala Pro 
        115                 120                 125             


Glu Ser Ile Pro Ser Leu Glu Ala Leu Asn Arg Lys Val His Asn Phe 
    130                 135                 140                 


Gln Met Glu Cys Ser Leu Gln Ala Lys Pro Ala Val Pro Thr Ser Lys 
145                 150                 155                 160 


Leu Gly Gln Ala Glu Gly Arg Asp Ala Gly Ser Ala Pro Ser Gly Gly 
                165                 170                 175     


Asp Pro Ala Phe Leu Gly Met Ala Val Asn Thr Leu Cys Gly Glu Val 
            180                 185                 190         


Pro Leu Tyr Tyr Ile 
        195         


<210>  2233
<211>  2487
<212>  DNA
<213>  Homosapiens

<400>  2233
gccgcttccc tcgccgccgc cccgccagca tgcccggcgt ggcccgcctg ccgctgctgc     60

tcgggctgct gctgctcccg cgtcccggcc ggccgctgga cttggccgac tacacctatg    120

acctggcgga ggaggacgac tcggagcccc tcaactacaa agacccctgc aaggcggctg    180

cctttcttgg ggacattgcc ctggacgaag aggacctgag ggccttccag gtacagcagg    240

ctgtggatct cagacggcac acagctcgta agtcctccat caaagctgca gttccaggaa    300

acacttctac ccccagctgc cagagcacca acgggcagcc tcagagggga gcctgtggga    360

gatggagagg tagatcccgt agccggcggg cggcgacgtc ccgaccagag cgtgtgtggc    420

ccgatggggt catccccttt gtcattgggg gaaacttcac tggtagccag agggcagtct    480

tccggcaggc catgaggcac tgggagaagc acacctgtgt caccttcctg gagcgcactg    540

acgaggacag ctatattgtg ttcacctatc gaccttgcgg gtgctgctcc tacgtgggtc    600

gccgcggcgg gggcccccag gccatctcca tcggcaagaa ctgtgacaag ttcggcattg    660

tggtccacga gctgggccac gtcgtcggct tctggcacga acacactcgg ccagaccggg    720

accgccacgt ttccatcgtt cgtgagaaca tccagccagg gcaggagtat aacttcctga    780

agatggagcc tcaggaggtg gagtccctgg gggagaccta tgacttcgac agcatcatgc    840

attacgctcg gaacacattc tccaggggca tcttcctgga taccattgtc cccaagtatg    900

aggtgaacgg ggtgaaacct cccattggcc aaaggacacg gctcagcaag ggggacattg    960

cccaagcccg caagctttac aagtgcccag cctgtggaga gaccctgcaa gacagcacag   1020

gcaacttctc ctcccctgaa taccccaatg gctactctgc tcacatgcac tgcgtgtggc   1080

gcatctctgt cacacccggg gagaagatca tcctgaactt cacgtccctg gacctgtacc   1140

gcagccgcct gtgctggtac gactatgtgg aggtccgaga tggcttctgg aggaaggcgc   1200

ccctccgagg ccgcttctgc gggtccaaac tccctgagcc tatcgtctcc actgacagcc   1260

gcctctgggt tgaattccgc agcagcagca attgggttgg aaagggcttc tttgcagtct   1320

acgaagccat ctgcgggggt gatgtgaaaa aggactatgg ccacattcaa tcgcccaact   1380

acccagacga ttaccggccc agcaaagtct gcatctggcg gatccaggtg tctgagggct   1440

tccacgtggg cctcacattc cagtcctttg agattgagcg ccacgacagc tgtgcctacg   1500

actatctgga ggtgcgcgac gggcacagtg agagcagcac cctcatcggg cgctactgtg   1560

gctatgagaa gcctgatgac atcaagagca cgtccagccg cctctggctc aagttcgtct   1620

ctgacgggtc cattaacaaa gcgggctttg ccgtcaactt tttcaaagag gtggacgagt   1680

gctctcggcc caaccgcggg ggctgtgagc agcggtgcct caacaccctg ggcagctaca   1740

agtgcagctg tgaccccggg tacgagctgg ccccagacaa gcgccgctgt gaggctgctt   1800

gtggcggatt cctcaccaag ctcaacggct ccatcaccag cccgggctgg cccaaggagt   1860

acccccccaa caagaactgc atctggcagc tggtggcccc cacccagtac cgcatctccc   1920

tgcagtttga cttctttgag acagagggca atgatgtgtg caagtacgac ttcgtggagg   1980

tgcgcagtgg actcacagct gactccaagc tgcatggcaa gttctgtggt tctgagaagc   2040

ccgaggtcat cacctcccag tacaacaaca tgcgcgtgga gttcaagtcc gacaacaccg   2100

tgtccaaaaa gggcttcaag gcccacttct tctcagaaaa gaggccagct ctgcagcccc   2160

ctcggggacg cccccaccag ctcaaattcc gagtgcagaa aagaaaccgg accccccagt   2220

gaggcctgcc aggcctcccg gaccccttgt tactcaggaa cctcaccttg gacggaatgg   2280

gatgggggct tcggtgccca ccaacccccc acctccactc tgccattccg gcccacctcc   2340

ctctggccgg acagaactgg tgctctcttc tccccactgt gcccgtccgc ggaccgggga   2400

cccttccccg tgccctaccc cctcccattt tgatggtgtc tgtgacattt cctgttgtga   2460

agtaaaagag ggacccctgc gtcctgc                                       2487


<210>  2234
<211>  730
<212>  PRT
<213>  Homosapiens

<400>  2234

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly 
            580                 585                 590         


Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro 
        595                 600                 605             


Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro 
    610                 615                 620                 


Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly 
625                 630                 635                 640 


Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr 
                645                 650                 655     


Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu 
            660                 665                 670         


Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp 
        675                 680                 685             


Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Glu Lys 
    690                 695                 700                 


Arg Pro Ala Leu Gln Pro Pro Arg Gly Arg Pro His Gln Leu Lys Phe 
705                 710                 715                 720 


Arg Val Gln Lys Arg Asn Arg Thr Pro Gln 
                725                 730 


<210>  2235
<211>  2853
<212>  DNA
<213>  Homosapiens

<400>  2235
gccgcttccc tcgccgccgc cccgccagca tgcccggcgt ggcccgcctg ccgctgctgc     60

tcgggctgct gctgctcccg cgtcccggcc ggccgctgga cttggccgac tacacctatg    120

acctggcgga ggaggacgac tcggagcccc tcaactacaa agacccctgc aaggcggctg    180

cctttcttgg ggacattgcc ctggacgaag aggacctgag ggccttccag gtacagcagg    240

ctgtggatct cagacggcac acagctcgta agtcctccat caaagctgca gttccaggaa    300

acacttctac ccccagctgc cagagcacca acgggcagcc tcagagggga gcctgtggga    360

gatggagagg tagatcccgt agccggcggg cggcgacgtc ccgaccagag cgtgtgtggc    420

ccgatggggt catccccttt gtcattgggg gaaacttcac tggtagccag agggcagtct    480

tccggcaggc catgaggcac tgggagaagc acacctgtgt caccttcctg gagcgcactg    540

acgaggacag ctatattgtg ttcacctatc gaccttgcgg gtgctgctcc tacgtgggtc    600

gccgcggcgg gggcccccag gccatctcca tcggcaagaa ctgtgacaag ttcggcattg    660

tggtccacga gctgggccac gtcgtcggct tctggcacga acacactcgg ccagaccggg    720

accgccacgt ttccatcgtt cgtgagaaca tccagccagg gcaggagtat aacttcctga    780

agatggagcc tcaggaggtg gagtccctgg gggagaccta tgacttcgac agcatcatgc    840

attacgctcg gaacacattc tccaggggca tcttcctgga taccattgtc cccaagtatg    900

aggtgaacgg ggtgaaacct cccattggcc aaaggacacg gctcagcaag ggggacattg    960

cccaagcccg caagctttac aagtgcccag cctgtggaga gaccctgcaa gacagcacag   1020

gcaacttctc ctcccctgaa taccccaatg gctactctgc tcacatgcac tgcgtgtggc   1080

gcatctctgt cacacccggg gagaagatca tcctgaactt cacgtccctg gacctgtacc   1140

gcagccgcct gtgctggtac gactatgtgg aggtccgaga tggcttctgg aggaaggcgc   1200

ccctccgagg ccgcttctgc gggtccaaac tccctgagcc tatcgtctcc actgacagcc   1260

gcctctgggt tgaattccgc agcagcagca attgggttgg aaagggcttc tttgcagtct   1320

acgaagccat ctgcgggggt gatgtgaaaa aggactatgg ccacattcaa tcgcccaact   1380

acccagacga ttaccggccc agcaaagtct gcatctggcg gatccaggtg tctgagggct   1440

tccacgtggg cctcacattc cagtcctttg agattgagcg ccacgacagc tgtgcctacg   1500

actatctgga ggtgcgcgac gggcacagtg agagcagcac cctcatcggg cgctactgtg   1560

gctatgagaa gcctgatgac atcaagagca cgtccagccg cctctggctc aagttcgtct   1620

ctgacgggtc cattaacaaa gcgggctttg ccgtcaactt tttcaaagag gtggacgagt   1680

gctctcggcc caaccgcggg ggctgtgagc agcggtgcct caacaccctg ggcagctaca   1740

agtgcagctg tgaccccggg tacgagctgg ccccagacaa gcgccgctgt gaggctgctt   1800

gtggcggatt cctcaccaag ctcaacggct ccatcaccag cccgggctgg cccaaggagt   1860

acccccccaa caagaactgc atctggcagc tggtggcccc cacccagtac cgcatctccc   1920

tgcagtttga cttctttgag acagagggca atgatgtgtg caagtacgac ttcgtggagg   1980

tgcgcagtgg actcacagct gactccaagc tgcatggcaa gttctgtggt tctgagaagc   2040

ccgaggtcat cacctcccag tacaacaaca tgcgcgtgga gttcaagtcc gacaacaccg   2100

tgtccaaaaa gggcttcaag gcccacttct tctcagtctt ggagggggca ggggaccgac   2160

actcacatct atcaggcctg gagttactgc tctgccccca tgccctggtc gacactgtgc   2220

ccgccccacc ctcagccctg cacggagaca cacacgccca cacgcacaca catgtgcaca   2280

cacattgccc catcgcacaa gaaacctgca gaggaccccc actgggggca tcgaggctca   2340

gccctcaggg cccggggcat ctgactctgg ccccccagga ggggagctat ttggactttt   2400

gggacaccca ccgaggagac cctaagccaa gaaggagaag aaagagcctg aagaccttca   2460

gtctgacccc tgccaccttc cggggcattt gggcactgta ggaaaagagg ccagctctgc   2520

agccccctcg gggacgcccc caccagctca aattccgagt gcagaaaaga aaccggaccc   2580

cccagtgagg cctgccaggc ctcccggacc ccttgttact caggaacctc accttggacg   2640

gaatgggatg ggggcttcgg tgcccaccaa ccccccacct ccactctgcc attccggccc   2700

acctccctct ggccggacag aactggtgct ctcttctccc cactgtgccc gtccgcggac   2760

cggggaccct tccccgtgcc ctaccccctc ccattttgat ggtgtctgtg acatttcctg   2820

ttgtgaagta aaagagggac ccctgcgtcc tgc                                2853


<210>  2236
<211>  823
<212>  PRT
<213>  Homosapiens

<400>  2236

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly 
            580                 585                 590         


Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro 
        595                 600                 605             


Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro 
    610                 615                 620                 


Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly 
625                 630                 635                 640 


Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr 
                645                 650                 655     


Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu 
            660                 665                 670         


Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp 
        675                 680                 685             


Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Val Leu 
    690                 695                 700                 


Glu Gly Ala Gly Asp Arg His Ser His Leu Ser Gly Leu Glu Leu Leu 
705                 710                 715                 720 


Leu Cys Pro His Ala Leu Val Asp Thr Val Pro Ala Pro Pro Ser Ala 
                725                 730                 735     


Leu His Gly Asp Thr His Ala His Thr His Thr His Val His Thr His 
            740                 745                 750         


Cys Pro Ile Ala Gln Glu Thr Cys Arg Gly Pro Pro Leu Gly Ala Ser 
        755                 760                 765             


Arg Leu Ser Pro Gln Gly Pro Gly His Leu Thr Leu Ala Pro Gln Glu 
    770                 775                 780                 


Gly Ser Tyr Leu Asp Phe Trp Asp Thr His Arg Gly Asp Pro Lys Pro 
785                 790                 795                 800 


Arg Arg Arg Arg Lys Ser Leu Lys Thr Phe Ser Leu Thr Pro Ala Thr 
                805                 810                 815     


Phe Arg Gly Ile Trp Ala Leu 
            820             


<210>  2237
<211>  3552
<212>  DNA
<213>  Homosapiens

<400>  2237
atgcccggcg tggcccgcct gccgctgctg ctcgggctgc tgctgctccc gcgtcccggc     60

cggccgctgg acttggccga ctacacctat gacctggcgg aggaggacga ctcggagccc    120

ctcaactaca aagacccctg caaggcggct gcctttcttg gggacattgc cctggacgaa    180

gaggacctga gggccttcca ggtacagcag gctgtggatc tcagacggca cacagctcgt    240

aagtcctcca tcaaagctgc agttccagga aacacttcta cccccagctg ccagagcacc    300

aacgggcagc ctcagagggg agcctgtggg agatggagag gtagatcccg tagccggcgg    360

gcggcgacgt cccgaccaga gcgtgtgtgg cccgatgggg tcatcccctt tgtcattggg    420

ggaaacttca ctggtagcca gagggcagtc ttccggcagg ccatgaggca ctgggagaag    480

cacacctgtg tcaccttcct ggagcgcact gacgaggaca gctatattgt gttcacctat    540

cgaccttgcg ggtgctgctc ctacgtgggt cgccgcggcg ggggccccca ggccatctcc    600

atcggcaaga actgtgacaa gttcggcatt gtggtccacg agctgggcca cgtcgtcggc    660

ttctggcacg aacacactcg gccagaccgg gaccgccacg tttccatcgt tcgtgagaac    720

atccagccag ggcaggagta taacttcctg aagatggagc ctcaggaggt ggagtccctg    780

ggggagacct atgacttcga cagcatcatg cattacgctc ggaacacatt ctccaggggc    840

atcttcctgg ataccattgt ccccaagtat gaggtgaacg gggtgaaacc tcccattggc    900

caaaggacac ggctcagcaa gggggacatt gcccaagccc gcaagcttta caagtgccca    960

gcctgtggag agaccctgca agacagcaca ggcaacttct cctcccctga ataccccaat   1020

ggctactctg ctcacatgca ctgcgtgtgg cgcatctctg tcacacccgg ggagaagatc   1080

atcctgaact tcacgtccct ggacctgtac cgcagccgcc tgtgctggta cgactatgtg   1140

gaggtccgag atggcttctg gaggaaggcg cccctccgag gccgcttctg cgggtccaaa   1200

ctccctgagc ctatcgtctc cactgacagc cgcctctggg ttgaattccg cagcagcagc   1260

aattgggttg gaaagggctt ctttgcagtc tacgaagcca tctgcggggg tgatgtgaaa   1320

aaggactatg gccacattca atcgcccaac tacccagacg attaccggcc cagcaaagtc   1380

tgcatctggc ggatccaggt gtctgagggc ttccacgtgg gcctcacatt ccagtccttt   1440

gagattgagc gccacgacag ctgtgcctac gactatctgg aggtgcgcga cgggcacagt   1500

gagagcagca ccctcatcgg gcgctactgt ggctatgaga agcctgatga catcaagagc   1560

acgtccagcc gcctctggct caagttcgtc tctgacgggt ccattaacaa agcgggcttt   1620

gccgtcaact ttttcaaaga ggtggacgag tgctctcggc ccaaccgcgg gggctgtgag   1680

cagcggtgcc tcaacaccct gggcagctac aagtgcagct gtgaccccgg gtacgagctg   1740

gccccagaca agcgccgctg tgaggctgct tgtggcggat tcctcaccaa gctcaacggc   1800

tccatcacca gcccgggctg gcccaaggag taccccccca acaagaactg catctggcag   1860

ctggtggccc ccacccagta ccgcatctcc ctgcagtttg acttctttga gacagagggc   1920

aatgatgtgt gcaagtacga cttcgtggag gtgcgcagtg gactcacagc tgactccaag   1980

ctgcatggca agttctgtgg ttctgagaag cccgaggtca tcacctccca gtacaacaac   2040

atgcgcgtgg agttcaagtc cgacaacacc gtgtccaaaa agggcttcaa ggcccacttc   2100

ttctcagaca aggacgagtg ctccaaggat aacggcggct gccagcagga ctgcgtcaac   2160

acgttcggca gttatgagtg ccaatgccgc agtggcttcg tcctccatga caacaagcac   2220

gactgcaaag aagccggctg tgaccacaag gtgacatcca ccagtggtac catcaccagc   2280

cccaactggc ctgacaagta tcccagcaag aaggagtgca cgtgggccat ctccagcacc   2340

cccgggcacc gggtcaagct gaccttcatg gagatggaca tcgagtccca gcctgagtgt   2400

gcctacgacc acctagaggt gttcgacggg cgagacgcca aggcccccgt cctcggccgc   2460

ttctgtggga gcaagaagcc cgagcccgtc ctggccacag gcagccgcat gttcctgcgc   2520

ttctactcag ataactcggt ccagcgaaag ggcttccagg cctcccacgc cacagagtgc   2580

gggggccagg tacgggcaga cgtgaagacc aaggaccttt actcccacgc ccagtttggc   2640

gacaacaact accctggggg tgtggactgt gagtgggtca ttgtggccga ggaaggctac   2700

ggcgtggagc tcgtgttcca gacctttgag gtggaggagg agaccgactg cggctatgac   2760

tacatggagc tcttcgacgg ctacgacagc acagccccca ggctggggcg ctactgtggc   2820

tcagggcctc ctgaggaggt gtactcggcg ggagattctg tcctggtgaa gttccactcg   2880

gatgacacca tcaccaaaaa aggtttccac ctgcgataca ccagcaccaa gttccaggac   2940

acactccaca gcaggaagtg accactgcct gagcaggggc ggggactgga gcctgctgcc   3000

cttggtcgcc tagactggat agtgggggtg ggcggaacgc aacgcaccat ccctctcccc   3060

caggccccag gacctgcagg gccaatggcc tggtgagact gtccatagga ggtgggggaa   3120

ctggactccg gcataagcca cttccccaca aacccccacc agcaaggggc tggggccagg   3180

gagcagagct tccacaagac atttcgaagt catcattcct ctcttagggg gccctgcctg   3240

gtggcaagag ggaatgtcag caggacccca tcgccatccc tgtgtctcta cacgctgtat   3300

tgtgtatcac cgggggcatt attttcattg taatgttcat ttcccacccc tgctccagcc   3360

tcgatttggt tttattttga gcccccattc caccacagtt tcctggggca caagtgtctg   3420

tgcatgtccc ccaggagcca ccgtggggag ccgatgggga ggggatggag aaacaagaca   3480

gggcttctct cagcccatgg ccggtcagcc acaccagggc accgcagcca ataaaccgaa   3540

agtgttacag cc                                                       3552


<210>  2238
<211>  986
<212>  PRT
<213>  Homosapiens

<400>  2238

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly 
            580                 585                 590         


Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro 
        595                 600                 605             


Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro 
    610                 615                 620                 


Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly 
625                 630                 635                 640 


Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr 
                645                 650                 655     


Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu 
            660                 665                 670         


Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp 
        675                 680                 685             


Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Asp Lys 
    690                 695                 700                 


Asp Glu Cys Ser Lys Asp Asn Gly Gly Cys Gln Gln Asp Cys Val Asn 
705                 710                 715                 720 


Thr Phe Gly Ser Tyr Glu Cys Gln Cys Arg Ser Gly Phe Val Leu His 
                725                 730                 735     


Asp Asn Lys His Asp Cys Lys Glu Ala Gly Cys Asp His Lys Val Thr 
            740                 745                 750         


Ser Thr Ser Gly Thr Ile Thr Ser Pro Asn Trp Pro Asp Lys Tyr Pro 
        755                 760                 765             


Ser Lys Lys Glu Cys Thr Trp Ala Ile Ser Ser Thr Pro Gly His Arg 
    770                 775                 780                 


Val Lys Leu Thr Phe Met Glu Met Asp Ile Glu Ser Gln Pro Glu Cys 
785                 790                 795                 800 


Ala Tyr Asp His Leu Glu Val Phe Asp Gly Arg Asp Ala Lys Ala Pro 
                805                 810                 815     


Val Leu Gly Arg Phe Cys Gly Ser Lys Lys Pro Glu Pro Val Leu Ala 
            820                 825                 830         


Thr Gly Ser Arg Met Phe Leu Arg Phe Tyr Ser Asp Asn Ser Val Gln 
        835                 840                 845             


Arg Lys Gly Phe Gln Ala Ser His Ala Thr Glu Cys Gly Gly Gln Val 
    850                 855                 860                 


Arg Ala Asp Val Lys Thr Lys Asp Leu Tyr Ser His Ala Gln Phe Gly 
865                 870                 875                 880 


Asp Asn Asn Tyr Pro Gly Gly Val Asp Cys Glu Trp Val Ile Val Ala 
                885                 890                 895     


Glu Glu Gly Tyr Gly Val Glu Leu Val Phe Gln Thr Phe Glu Val Glu 
            900                 905                 910         


Glu Glu Thr Asp Cys Gly Tyr Asp Tyr Met Glu Leu Phe Asp Gly Tyr 
        915                 920                 925             


Asp Ser Thr Ala Pro Arg Leu Gly Arg Tyr Cys Gly Ser Gly Pro Pro 
    930                 935                 940                 


Glu Glu Val Tyr Ser Ala Gly Asp Ser Val Leu Val Lys Phe His Ser 
945                 950                 955                 960 


Asp Asp Thr Ile Thr Lys Lys Gly Phe His Leu Arg Tyr Thr Ser Thr 
                965                 970                 975     


Lys Phe Gln Asp Thr Leu His Ser Arg Lys 
            980                 985     


<210>  2239
<211>  2964
<212>  DNA
<213>  Homosapiens

<400>  2239
cttctctgcc tctctctcct ccacgctgct ttgatttcgc tcttgcctct cttcttgcgc     60

tgctcagctg ggaacatcgg ctcaccaggg gcagcagcga cgcgctgcac agccagacag    120

gagctggttg cggggcatgg aagcagcctc cttggcagcc gggagaggag caagcgcacg    180

ccactgcccg tgacccaggc gtccggctgc tgtcccctgc cggggagctc atccacgcag    240

aggtctctcc ctgtcctccc tgcgagcttt tcctctgcag agcccagtgg agccagtccc    300

cacaggagac aaccctgacg ggagcatgga gctgctgtcc acgccccaca gcattgagat    360

caacaacatc acctgcgact ccttcagcat ctcctgggcc atggaggaca gtgacctgga    420

gagggtcacc cattacttca ttgaccttaa caagaaggag aataagaatt ccaacaagtt    480

caagcaccgg gacgtcccca ccaagctcgt ggccaaggca gtgccgctgc ccatgacggt    540

gagaggccac tggttcctga gcccccgcac ggagtacagt gtggccgtgc agacggcagt    600

gaagcagagc gatggggagt acctggtgtc cggctggagc gagacggtgg agttctgcac    660

tggggattat gccaaggagc acctggctca gcttcaggag aaagctgagc agatcgcagg    720

ccgcatgctc cgcttctccg tcttctaccg caaccatcac aaggagtact tcgagcatgc    780

caggacccac tgcgggaaca tgctgcagcc ttacctgaag gacaacagcg gcagccacgg    840

ctcccccacc agcggtatgc tccacggggt cttcttcagc tgcaacacgg agttcaacac    900

gggccagccc ccgcaggact ccccctacgg ccgctggcgc ttccagatcc cagctcagcg    960

cctcttcaat cccagcacca acctctactt tgcggacttc tactgcatgt acacggccta   1020

ccactacgcc atcctggtgc tggcgcccaa aggctccatg ggggaccgct tctgccgcga   1080

ccgccggccc ctcctggaca ttgcttgcaa caagttcctg acctgcagcg tggaggatgg   1140

ggagctggtc ttccgccacg cccaggacct catcctggag atcatctaca ctgagcccgt   1200

cgacctgtcc ctgggcaccc tgggggagat cagtgggcac cagctcatga gtctgtctac   1260

tgccgatgcc aagaaggacc ccagctgcaa gacctgcaac atcagcgtgg gccgctaggg   1320

actcctgggg agctgggggg cgagggagag atgagcggaa ggtggaggtg ggtagcccag   1380

gttcagggag ctggctttct ctctcctgcc cccctgctcc ctccactctg cccagctgcc   1440

ctcccctcgc cccttggcat tggaggcaac agacggtggt cctcttggta agtgtggccc   1500

acacccagcc tggtggacat ggaaaggctt ctcagcctct gtagttggca gctgggctgg   1560

acttctggag aacttcccct ttcctctggt ttccttgtcc tactgttctt tgcctcgtcc   1620

aggtctctat ctcccaaaga cctgcccacc tcctgggctc tcccagggaa gcccctctgg   1680

gccaaagccc atgggtagct tggctgcctc cagaagagat gcagagagct gtggggcgat   1740

ctttcttagt cccactcacc ccactcaggg ccaaccacag aatgccccct ccctgctgag   1800

ctgggtctct ggggcttccc actccaggcc tggatccctt ccttctataa atagtctcct   1860

gcaccaccgt gactccctgg ctgctccttg ccccaaagaa ccctcttcct gcatgggaga   1920

gctgtccctc cttctcaacc tgcccaccgg gacactcccc ctgctctcta gaaaggaact   1980

ctctttcttc tcttggcact gggggcgtca ggctgtcgga tgttccttcc ttccataccc   2040

cagcatacct tctccttgct tagagtgcag gggtctgaga cagcagccac tggggttgag   2100

gagggggagg agacccctga gacccagagg tgccccttcc tcagctggga gtgggccgcc   2160

tcatgctctg ctggggcctg gcatggaacg tgagacctgt aagctgtccc gcgggccccg   2220

gcaccccgcc cagctgtgca ctttgctcac tcgctctgcc atggtgccat gactgtactg   2280

tgcccatgcg tgacctggac tgtggaccct ctgctgctcc gcctctcccc tccccactgg   2340

ctctgtctgc tctcctgcca ccctgctggc ggggagcccc tccccgggga gttcttggtg   2400

aagtccttcc cgggcctcct tgtgtttttg cctcattcct actgtcacac aggtcacgag   2460

ggtggactcc ctacaatcaa caaagcaaac agagagcctg tgggaggggc tgacagcagc   2520

aggcggctgt ttgggggatg atggaggtga catcaggcag aggagagtgc agcctcacag   2580

tgactttctc agaggtgaca gagatgatgg atgagcagct ggattttcgt gatgaaggac   2640

ggaagcagca gcgggccggc aaggccatac ctcggtgagg gacaggtgga caacggtcac   2700

ctatctgtag ccaggggcag ttgtgtggcc agctgtctct ctgggatgag tcaggaggcc   2760

tggaggcttg gggagaggtg tggagaagga gagaacatgg cccaggcact ttccttcacc   2820

ctgtgctgac agcattgctg tgggggtggc ccactgccct cccctggccc tcatgtcccc   2880

ccggggctgg ggtccgcctg cctgtgctgt gcttgcgacg tgcatcaata aaccaccatg   2940

gcctgaggaa aaaaaaaaaa aaaa                                          2964


<210>  2240
<211>  330
<212>  PRT
<213>  Homosapiens

<400>  2240

Met Glu Leu Leu Ser Thr Pro His Ser Ile Glu Ile Asn Asn Ile Thr 
1               5                   10                  15      


Cys Asp Ser Phe Ser Ile Ser Trp Ala Met Glu Asp Ser Asp Leu Glu 
            20                  25                  30          


Arg Val Thr His Tyr Phe Ile Asp Leu Asn Lys Lys Glu Asn Lys Asn 
        35                  40                  45              


Ser Asn Lys Phe Lys His Arg Asp Val Pro Thr Lys Leu Val Ala Lys 
    50                  55                  60                  


Ala Val Pro Leu Pro Met Thr Val Arg Gly His Trp Phe Leu Ser Pro 
65                  70                  75                  80  


Arg Thr Glu Tyr Ser Val Ala Val Gln Thr Ala Val Lys Gln Ser Asp 
                85                  90                  95      


Gly Glu Tyr Leu Val Ser Gly Trp Ser Glu Thr Val Glu Phe Cys Thr 
            100                 105                 110         


Gly Asp Tyr Ala Lys Glu His Leu Ala Gln Leu Gln Glu Lys Ala Glu 
        115                 120                 125             


Gln Ile Ala Gly Arg Met Leu Arg Phe Ser Val Phe Tyr Arg Asn His 
    130                 135                 140                 


His Lys Glu Tyr Phe Glu His Ala Arg Thr His Cys Gly Asn Met Leu 
145                 150                 155                 160 


Gln Pro Tyr Leu Lys Asp Asn Ser Gly Ser His Gly Ser Pro Thr Ser 
                165                 170                 175     


Gly Met Leu His Gly Val Phe Phe Ser Cys Asn Thr Glu Phe Asn Thr 
            180                 185                 190         


Gly Gln Pro Pro Gln Asp Ser Pro Tyr Gly Arg Trp Arg Phe Gln Ile 
        195                 200                 205             


Pro Ala Gln Arg Leu Phe Asn Pro Ser Thr Asn Leu Tyr Phe Ala Asp 
    210                 215                 220                 


Phe Tyr Cys Met Tyr Thr Ala Tyr His Tyr Ala Ile Leu Val Leu Ala 
225                 230                 235                 240 


Pro Lys Gly Ser Met Gly Asp Arg Phe Cys Arg Asp Arg Arg Pro Leu 
                245                 250                 255     


Leu Asp Ile Ala Cys Asn Lys Phe Leu Thr Cys Ser Val Glu Asp Gly 
            260                 265                 270         


Glu Leu Val Phe Arg His Ala Gln Asp Leu Ile Leu Glu Ile Ile Tyr 
        275                 280                 285             


Thr Glu Pro Val Asp Leu Ser Leu Gly Thr Leu Gly Glu Ile Ser Gly 
    290                 295                 300                 


His Gln Leu Met Ser Leu Ser Thr Ala Asp Ala Lys Lys Asp Pro Ser 
305                 310                 315                 320 


Cys Lys Thr Cys Asn Ile Ser Val Gly Arg 
                325                 330 


<210>  2241
<211>  1946
<212>  DNA
<213>  Homosapiens

<400>  2241
gatggcggcg cccaggccct gccacgcaga cttccgcccg gcgcggagac cgaaggctgg     60

cggctggtcg cgttgcaggc aacatgtcgg aaggaaacgc cgccggcgag cccagcacgc    120

cgggagggcc ccgacctctc ctgactgggg cccgggggct catcgggcgg cggccggcgc    180

ctcccctcac ccccggccgc cttccctcca tccgttccag ggacctcacc ctcgggggag    240

tcaagaagaa aaccttcacc ccaaatatca tcagtcggaa gatcaaggaa gagcccaagg    300

aagaagtaac tgtcaagaag gagaagcgtg aaagggacag agaccgacaa cgagaggggc    360

atggacgagg gcgaggccgt ccagaagtga tccagtctca ctccatcttt gagcagggcc    420

cagctgaaat gatgaagaaa aaagggaact gggataagac agtggatgtg tcagacatgg    480

gaccttctca tatcatcaac atcaaaaaag agaagagaga gacagacgaa gaaactaaac    540

agatcttgcg tatgctggag aaggacgatt tcctcgatga ccccggcctg aggaacgaca    600

ctcgaaatat gcctgtgcag ctgccgctgg ctcactcagg atggcttttt aaggaagaaa    660

atgacgaacc agatgttaaa ccttggctgg ctggccccaa ggaagaggac atggaggtgg    720

acatacctgc tgtgaaagtg aaagaggagc cacgagatga ggaggaagag gccaagatga    780

aggctcctcc caaagcagcc aggaagactc caggcctccc gaaggatgta tctgtggcag    840

agctgctgag ggagctgagc ctcaccaagg aagaggaact gctgtttctg cagctgccag    900

acaccctccc tggccagcca cccacccagg acatcaagcc tatcaagaca gaggtgcagg    960

gcgaggacgg acaggtggtg ctcatcaagc aggagaaaga ccgagaagcc aaattggcag   1020

agaatgcttg taccctggct gacctgacag agggtcaggt tggcaagcta ctcatccgca   1080

agtctggaag ggtgcaactc ctcttgggca aggtgactct ggacgtgacc atgggaactg   1140

cctgctcctt cctgcaggag ctggtgtccg tgggccttgg agacagtagg acaggggaga   1200

tgacagtcct gggacacgtg aagcacaaac ttgtatgttc ccctgatttt gaatccctct   1260

tggatcacaa acaccggtaa aatgagcagg tggaggagga cggcgcctgt gcccacggct   1320

gctgcctgct ccagacattt tgttcttgaa tctgtgagac ccagaagggg cccactgagc   1380

ccactcactc cagcctttgg caaccattgt tccaggtccc ccagggcttc ctcccacagc   1440

agctgtgaat ggcacagtga ccttcctgca gcgtggagat ggcacatcct tgctgctggg   1500

gacttggccc tgctatttat ttttgtattt atgtcttaat ctcttccact gatgcatcct   1560

ccaagggtag atggggaggg tctgtgtgaa ggggccggct tctcttggtg cctgctgggt   1620

tgcaggggca ggaagcgtgt ggactgcagc ttctgctggt gctccccccg tcctcctgga   1680

ggcagtatag gagagagagc aaggattgag tctgagactt aagcactcgg tcccagcttg   1740

ccagttcctg gttctgtgtc cttggacaaa ctacctaacc tttctgagcc tcctatacct   1800

catccgacac aaatggggat gatacctacc tccagggttg gcgtgaggat tcatgggcta   1860

ttatagatga aaactgcaca aggccagaac cagcaggcac tcaataaacg ttcatgtcct   1920

ttttctctaa aaaaaaaaaa aaaaaa                                        1946


<210>  2242
<211>  398
<212>  PRT
<213>  Homosapiens

<400>  2242

Met Ser Glu Gly Asn Ala Ala Gly Glu Pro Ser Thr Pro Gly Gly Pro 
1               5                   10                  15      


Arg Pro Leu Leu Thr Gly Ala Arg Gly Leu Ile Gly Arg Arg Pro Ala 
            20                  25                  30          


Pro Pro Leu Thr Pro Gly Arg Leu Pro Ser Ile Arg Ser Arg Asp Leu 
        35                  40                  45              


Thr Leu Gly Gly Val Lys Lys Lys Thr Phe Thr Pro Asn Ile Ile Ser 
    50                  55                  60                  


Arg Lys Ile Lys Glu Glu Pro Lys Glu Glu Val Thr Val Lys Lys Glu 
65                  70                  75                  80  


Lys Arg Glu Arg Asp Arg Asp Arg Gln Arg Glu Gly His Gly Arg Gly 
                85                  90                  95      


Arg Gly Arg Pro Glu Val Ile Gln Ser His Ser Ile Phe Glu Gln Gly 
            100                 105                 110         


Pro Ala Glu Met Met Lys Lys Lys Gly Asn Trp Asp Lys Thr Val Asp 
        115                 120                 125             


Val Ser Asp Met Gly Pro Ser His Ile Ile Asn Ile Lys Lys Glu Lys 
    130                 135                 140                 


Arg Glu Thr Asp Glu Glu Thr Lys Gln Ile Leu Arg Met Leu Glu Lys 
145                 150                 155                 160 


Asp Asp Phe Leu Asp Asp Pro Gly Leu Arg Asn Asp Thr Arg Asn Met 
                165                 170                 175     


Pro Val Gln Leu Pro Leu Ala His Ser Gly Trp Leu Phe Lys Glu Glu 
            180                 185                 190         


Asn Asp Glu Pro Asp Val Lys Pro Trp Leu Ala Gly Pro Lys Glu Glu 
        195                 200                 205             


Asp Met Glu Val Asp Ile Pro Ala Val Lys Val Lys Glu Glu Pro Arg 
    210                 215                 220                 


Asp Glu Glu Glu Glu Ala Lys Met Lys Ala Pro Pro Lys Ala Ala Arg 
225                 230                 235                 240 


Lys Thr Pro Gly Leu Pro Lys Asp Val Ser Val Ala Glu Leu Leu Arg 
                245                 250                 255     


Glu Leu Ser Leu Thr Lys Glu Glu Glu Leu Leu Phe Leu Gln Leu Pro 
            260                 265                 270         


Asp Thr Leu Pro Gly Gln Pro Pro Thr Gln Asp Ile Lys Pro Ile Lys 
        275                 280                 285             


Thr Glu Val Gln Gly Glu Asp Gly Gln Val Val Leu Ile Lys Gln Glu 
    290                 295                 300                 


Lys Asp Arg Glu Ala Lys Leu Ala Glu Asn Ala Cys Thr Leu Ala Asp 
305                 310                 315                 320 


Leu Thr Glu Gly Gln Val Gly Lys Leu Leu Ile Arg Lys Ser Gly Arg 
                325                 330                 335     


Val Gln Leu Leu Leu Gly Lys Val Thr Leu Asp Val Thr Met Gly Thr 
            340                 345                 350         


Ala Cys Ser Phe Leu Gln Glu Leu Val Ser Val Gly Leu Gly Asp Ser 
        355                 360                 365             


Arg Thr Gly Glu Met Thr Val Leu Gly His Val Lys His Lys Leu Val 
    370                 375                 380                 


Cys Ser Pro Asp Phe Glu Ser Leu Leu Asp His Lys His Arg 
385                 390                 395             


<210>  2243
<211>  3549
<212>  DNA
<213>  Homosapiens

<400>  2243
gtcttcccgg cgcccaggct tgggctcata gggagaaagg aagctgcgct gcattctgcg     60

ggacgaaccc tgctccgcgc gagaattttt ttgattcctt cttatttgga gaaatctcca    120

gctgctctga tgatagccta agaagactgc atgctgcttc ctctcgatgc caagccagac    180

cctctcacaa cctcggatct cagtccttca tggagacctg gtcccagcag gaatggcagt    240

gcaggaaatt ggcgcccaga tggttcttcc atgtgaagtt gtctcgggct ctgggctgac    300

gagagaacac ctggtaacca ggttagccct ctgtcagtca cccagggcag ggcagcatgg    360

tgcggattca gaggaggaag cttttggcat cttgcctgtg cgtcacagcc accgtctttc    420

tgcttgtcac actccaggtc atggttgagc tggggaagtt tgaaaggaag gagtttaaaa    480

gttccagttt gcaagatgga catacaaaaa tggaggaagc acctacgcat cttaattcat    540

ttcttaagaa agaaggattg accttcaaca ggaaaagaaa atgggaattg gacagctacc    600

ccattatgct ctggtggtcc ccgctgacgg gggagactgg gaggttaggc caatgtggag    660

cagatgcttg tttcttcacc atcaaccgga cctacctcca tcatcacatg accaaagcat    720

tcctcttcta tggtactgac tttaacatag atagcttacc tctgcctcgg aaagcccatc    780

atgactgggc tgtttttcat gaagagtccc cgaaaaacaa ttataagctc tttcataaac    840

cagtgatcac cttgttcaac tacactgcca cgttcagcag gcattcccac ttgccactaa    900

ctacccaata cttggagagc attgaagtcc tgaagtcact ccgataccta gttcctttgc    960

agtccaaaaa caagcttaga aaaagacttg ctccgctggt gtatgtacag tcagactgtg   1020

acccaccatc agacagggac agctatgttc gcgagctgat gacttacatc gaggtcgatt   1080

cctatggtga atgtttacga aacaaagacc tccctcagca gctgaaaaat ccagcctcta   1140

tggatgccga tggcttttat aggatcattg cacagtataa gtttatccta gcttttgaga   1200

atgcagtttg tgatgactac atcactgaga agttctggag gccactgaaa ctgggggtag   1260

tccctgtata ttacggatcc cccagcatca cagactggct tccaagtaac aaaagtgcta   1320

ttcttgtatc agaattttct caccccaggg aactggcaag ttacatcaga cgactggatt   1380

ctgatgacag attgtatgag gcctatgtag aatggaagct gaagggtgag atctctaacc   1440

agcgacttct gacagctctc agggaacgga aatggggagt gcaagacgtc aaccaggaca   1500

attacatcga tgcatttgag tgtatggtgt gcaccaaggt gtgggctaat atcaggcttc   1560

aggaaaaggg cttaccaccc aaaagatggg aggcagaaga tacccacctg agttgcccag   1620

agcccacagt gtttgctttc tcaccactcc ggactccacc tttgagctct ttgcgagaga   1680

tgtggatttc cagctttgaa caatccaaga aagaagccca ggcactaagg tggctggttg   1740

ataggaatca aaacttttca tctcaagagt tttggggcct agtattcaag gactgatttc   1800

aaaaatgatc agaatgaaac agactagagc cttcttgagg tttattttct aggttgcctt   1860

aatatttgaa cataatagct attctgttga ctatccatca ggataataat tagttgctgc   1920

agtactcata atgagccctt tcaaggaata gatgtaaatt acccttaggg gtagccacta   1980

tattttttat actaaaaaag gaaatatttc ttatggacac tggttatctt ccatgtccgt   2040

gtctgtggac ccacatactt actgcctttt gtggaaattc acctagagtg agtactttcc   2100

ttgtgcaatg gagggagacg atctagctat agattcttga tactcacctc actctcaaca   2160

gcttattggt atttggcaaa cctggtatcc tgcagccgag catgaacatg aaatacatta   2220

gaacttggca atgagagatc ccatctgttg gtttccaggg atgtaagtga gtaataaaag   2280

ctgtttcaag tttatccact atccactctt caagtgaaaa gaacttatgt gtgtctacct   2340

tcttctccat accctgagcc acctctctca ctttctttag ttgtgccttg ccctatcgcc   2400

tcccattttc ccttcaaagt agaatgtctt gtaaagacac agtaactcct gtgtgttttg   2460

attagtgaga tgttaccact taccccttct gctgcgcaga ataatattaa gaattgctat   2520

gcttatgatt caggctggac agcctggaca ttttgagcag cgcgagagta gaagtgaata   2580

cccccaggaa ctccaattgt gctgaagctg atttgtctgt tcgtaggatg atgtgcagcc   2640

tgtcacagtg gcagccacag gcattcagtt tgtgggcatt tcctgtcatt tcggatcctg   2700

ctatagggaa ggttcagctc tcctgtctgg ggcatctact ggagcacctc agaagacaag   2760

gaggaaaaca ctggctcatg ttttctttcc atgtgaggga ggggaggttt ctagatgata   2820

ctaaaagcct gttgccactg ttgtgtcatg atttccattc ttcatcatgg aaagccacaa   2880

gcctcagaag gcagccagag gacaggaaga gtctgtgatg ctcatgtctg tgtcatggca   2940

tgagggggaa ttgacgagtg cttgcttagc atcagctctc attgtattga aggctgtgcc   3000

cttggtgtgc ttagcagtga gcagcgtctt cattaggtag ctctggctgg gctttgtcag   3060

ccagcgtgtg agaaaggaga accaaaacca atacctcctt atagaagcca gaaggatcac   3120

attggatgag agaaggtgtc tataactggg ttcttcccaa tcccagctct ttcattaact   3180

aaatatgatc ttggacatat ctcttaacct ccatcggcct tagtttttgc atccaaaaag   3240

aagtgattgg gctggtcttg gaaggttttt ttcttttttt tcccctgtgt aacattcttc   3300

attgttcatc aacatttaag aaatttaatt ttgtagatgt ttttactaaa gagggtaaca   3360

aactattttg gaactgctgt atgttattca agggaagcac gctgtttgga ggaaggagca   3420

tacttaatgg gtagtattga ggatgaaagg gaatttctct ctctgccatt ttatttgata   3480

atattaaaga aataaagact ggaaaggggg attccttgtt aaaggtcaga ttttaaattg   3540

catataaaa                                                           3549


<210>  2244
<211>  479
<212>  PRT
<213>  Homosapiens

<400>  2244

Met Val Arg Ile Gln Arg Arg Lys Leu Leu Ala Ser Cys Leu Cys Val 
1               5                   10                  15      


Thr Ala Thr Val Phe Leu Leu Val Thr Leu Gln Val Met Val Glu Leu 
            20                  25                  30          


Gly Lys Phe Glu Arg Lys Glu Phe Lys Ser Ser Ser Leu Gln Asp Gly 
        35                  40                  45              


His Thr Lys Met Glu Glu Ala Pro Thr His Leu Asn Ser Phe Leu Lys 
    50                  55                  60                  


Lys Glu Gly Leu Thr Phe Asn Arg Lys Arg Lys Trp Glu Leu Asp Ser 
65                  70                  75                  80  


Tyr Pro Ile Met Leu Trp Trp Ser Pro Leu Thr Gly Glu Thr Gly Arg 
                85                  90                  95      


Leu Gly Gln Cys Gly Ala Asp Ala Cys Phe Phe Thr Ile Asn Arg Thr 
            100                 105                 110         


Tyr Leu His His His Met Thr Lys Ala Phe Leu Phe Tyr Gly Thr Asp 
        115                 120                 125             


Phe Asn Ile Asp Ser Leu Pro Leu Pro Arg Lys Ala His His Asp Trp 
    130                 135                 140                 


Ala Val Phe His Glu Glu Ser Pro Lys Asn Asn Tyr Lys Leu Phe His 
145                 150                 155                 160 


Lys Pro Val Ile Thr Leu Phe Asn Tyr Thr Ala Thr Phe Ser Arg His 
                165                 170                 175     


Ser His Leu Pro Leu Thr Thr Gln Tyr Leu Glu Ser Ile Glu Val Leu 
            180                 185                 190         


Lys Ser Leu Arg Tyr Leu Val Pro Leu Gln Ser Lys Asn Lys Leu Arg 
        195                 200                 205             


Lys Arg Leu Ala Pro Leu Val Tyr Val Gln Ser Asp Cys Asp Pro Pro 
    210                 215                 220                 


Ser Asp Arg Asp Ser Tyr Val Arg Glu Leu Met Thr Tyr Ile Glu Val 
225                 230                 235                 240 


Asp Ser Tyr Gly Glu Cys Leu Arg Asn Lys Asp Leu Pro Gln Gln Leu 
                245                 250                 255     


Lys Asn Pro Ala Ser Met Asp Ala Asp Gly Phe Tyr Arg Ile Ile Ala 
            260                 265                 270         


Gln Tyr Lys Phe Ile Leu Ala Phe Glu Asn Ala Val Cys Asp Asp Tyr 
        275                 280                 285             


Ile Thr Glu Lys Phe Trp Arg Pro Leu Lys Leu Gly Val Val Pro Val 
    290                 295                 300                 


Tyr Tyr Gly Ser Pro Ser Ile Thr Asp Trp Leu Pro Ser Asn Lys Ser 
305                 310                 315                 320 


Ala Ile Leu Val Ser Glu Phe Ser His Pro Arg Glu Leu Ala Ser Tyr 
                325                 330                 335     


Ile Arg Arg Leu Asp Ser Asp Asp Arg Leu Tyr Glu Ala Tyr Val Glu 
            340                 345                 350         


Trp Lys Leu Lys Gly Glu Ile Ser Asn Gln Arg Leu Leu Thr Ala Leu 
        355                 360                 365             


Arg Glu Arg Lys Trp Gly Val Gln Asp Val Asn Gln Asp Asn Tyr Ile 
    370                 375                 380                 


Asp Ala Phe Glu Cys Met Val Cys Thr Lys Val Trp Ala Asn Ile Arg 
385                 390                 395                 400 


Leu Gln Glu Lys Gly Leu Pro Pro Lys Arg Trp Glu Ala Glu Asp Thr 
                405                 410                 415     


His Leu Ser Cys Pro Glu Pro Thr Val Phe Ala Phe Ser Pro Leu Arg 
            420                 425                 430         


Thr Pro Pro Leu Ser Ser Leu Arg Glu Met Trp Ile Ser Ser Phe Glu 
        435                 440                 445             


Gln Ser Lys Lys Glu Ala Gln Ala Leu Arg Trp Leu Val Asp Arg Asn 
    450                 455                 460                 


Gln Asn Phe Ser Ser Gln Glu Phe Trp Gly Leu Val Phe Lys Asp 
465                 470                 475                 


<210>  2245
<211>  3549
<212>  DNA
<213>  Homosapiens

<400>  2245
cggacaccat gcagtcggat gatgttatct gggatacact aggaaacaag caattttgtt     60

ccttcaaaat aagaaccaag actcagagct tctgccgaaa tgaatatagc ctgactggac    120

tgtgtaatcg gtcatcctgt cccctggcaa atagtcagta tgccactatt aaagaagaga    180

aaggacagtg ctacttgtat atgaaggtta tagaacgagc ggcttttcct cggcgtctct    240

gggaacgggt ccggcttagt aaaaactatg agaaagcact ggagcaaata gatgaaaatc    300

tgatttactg gccccgtttc attcgacaca aatgtaagca gagattcacc aagatcaccc    360

aatacctaat tcgaattaga aaacttacac taaagcgaca gaggaaactt gttcctttga    420

gtaagaaggt ggagcgtagg gagaaaagaa gagaggaaaa ggcattaata gctgctcagc    480

tggacaatgc cattgagaag gaattactgg agagactgaa acaagatacg tatggcgaca    540

tctacaactt ccccattcat gccttcgaca aagccctgga acaacaggag gcagagagtg    600

actcttcaga tactgaggaa aaagatgatg atgatgatga tgaggaagat gtggggaaaa    660

gagaatttgt cgaagatggt gaggtagatg agagtgacat aagtgatttt gaggatatgg    720

ataaactgga tgccagcagt gatgaagatc aggatggtaa atcctccagt gaggaggagg    780

aagaaaaggc ccttagtgcg aaacacaaag gcaaaatgcc cttgagagga ccactgcaga    840

gaaaacgagc ctatgtggaa atagaatacg agcaggagac agagcccgtg gccaaagcca    900

aaaccacgtg atttcccttt cagcatttat acccaggact gaacatgcag aactgttttt    960

ttttttttat cttaaacaca tacacacctc cagtttttgc tcttttgtgt tgtactgaac   1020

acaatatttg tgtttttatt atttatgcca cgtcagtggg gcaagaaatc tggagtgagt   1080

gaagaaagct aagttgtgaa caagagtgtt tttatagcat atgtgttgaa gtaacagctt   1140

gtgcccgaga aacttaacag atgagttctt gaatctggga tgagatgacg gatgtaaata   1200

tttctaaatt ttaaatgcta cattacttgg tgtccttttt tctcccaaac tttatttaga   1260

aatggaagga gttcaatttt ttcttgttct actttcccta ttcttatgga ggtaaaagga   1320

aaggaaggaa ggaaaaagca gctttcactt acaaagtttc gtgtaaaaat atcttttttt   1380

cttaaataac tccattcata caaattggga tgggaagaaa atcctttcct cttgggaaag   1440

taatacaagt cttaagttcc attgtagggt gcgccttcag aaacctgctg cacttttctg   1500

atatagttca ccacttttct gtcttcacag ctttggggaa ttttggccag gagaccctga   1560

aacatgaaac caaacaggct ttgatatttt ttttttaatt actttcccct tttgcttgat   1620

tcttcttcct tggtatcata ttcaaaggag gaaagaatgg atgacactta gggacaggtc   1680

actaagcaga ataggtatta gttggttttt tattattttt aaatttatat agctctcatg   1740

tattgaaggt gctactttaa aaactgtgtt aatgtacttg caaatctcct gctggctcat   1800

gaaacagcag aattccagcc aaggcaaatt cagttggatc tagggcttga aaactgccca   1860

agattaaaga gctaagatga aatagtttga ataaactggt aaaataacaa ttcatactat   1920

ctctacatat ttttaggata tgaatttttt tttcctgctg ggtagattgt ccagtgactt   1980

atggcatgaa tttcttttca tgctaccttc aatcttcaac taaagatttc taaaaggggt   2040

aagaaatgag gcagtagttt attaaataca tagaagtaca cagctattat atgctgtggc   2100

tttgagaagt taacttttgt ggaatatgaa accaaaggaa gaatttccat gtagataaat   2160

taagaatagg gaaaaacatc tacctaaaag atggttgtcc ctaaaaaaac tggaaacatc   2220

tgaaatgctc tatttatgtt attattcctg ggagcttata gcccattatt tttacttttt   2280

ttttttaatt cagaagacta gaacagaact taaattttac aaacttttga tcataatgct   2340

tttgcccata ctgtctcgtc cttagcccca gtgacatgtg ctgatcctcc tgcctttagt   2400

tctaaatggt tctgaatagc tttaaaagat gaataagaaa aaagatcaag ctcttttgag   2460

gctagagggc tcatatggag atctaaaacc ctccatgttc atttccagac ttggtcaggc   2520

acatacatag taaattataa tcaatcatgg gaattacata aggataatga ggcccaactg   2580

aaaccaagtt tcagtctgcc ttacctttac ccgtccttga gaacagcggt ccaggagaat   2640

caggcagtct gtggcctcct gtagcagggc gctcttaaca gactcaggtg taaggtttgg   2700

atcccttgct acatcacaaa tcagtttcaa gagggccttc agtaagacca caagtctgca   2760

ggaaactctg gaatcaggaa gaaaagctat gttcatactc taaatctgga tattaaaatt   2820

ggaagagact tcaaagactg tcaagtggaa agctatcatt tcctaaatta aggaacttag   2880

gtcaaagtta aatgaaaaag acctaaaaac agaaccaaag acagcctcta gatttcttac   2940

cctcaagtct cctgttagca tactgcctat acacacagac acaccctctg ccacactgct   3000

ctcttccttc cagaagcttg gttctactgt aagcaacagc tccttcatgg gctgagaagg   3060

ggaaaccagg atctccccaa ccaagggcct atacttttat ttttcaactc tattaactga   3120

actatgcttg gagagagccc tgaatccttt aactttaatg ccatcttagg cctggaagtt   3180

agagtgaggg aaatgagctt ggcttctggg actgtgtcaa gttgaatttt ctgtcattta   3240

atttcagatc ctagctcatc atcagtgaag tccagcctac ttacttgtaa ctattaacct   3300

ttctaaaagt tttcatcgcc ttggtaaagc tccagaaatg gacaatgcta gtgactgcac   3360

aatattgtga ctgtacttaa tgccactgaa ctgtacactt taaaatggaa aatttatatg   3420

tatttttacc acaataaaca aaaaacccta aaaaaacttt aatgaaaggt ggaaaataat   3480

ttaacttaca atgtgaaaat acaatgtgaa atgtacaata aatcatattt atggaaaaaa   3540

aaaaaaaaa                                                           3549


<210>  2246
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  2246

Met Gln Ser Asp Asp Val Ile Trp Asp Thr Leu Gly Asn Lys Gln Phe 
1               5                   10                  15      


Cys Ser Phe Lys Ile Arg Thr Lys Thr Gln Ser Phe Cys Arg Asn Glu 
            20                  25                  30          


Tyr Ser Leu Thr Gly Leu Cys Asn Arg Ser Ser Cys Pro Leu Ala Asn 
        35                  40                  45              


Ser Gln Tyr Ala Thr Ile Lys Glu Glu Lys Gly Gln Cys Tyr Leu Tyr 
    50                  55                  60                  


Met Lys Val Ile Glu Arg Ala Ala Phe Pro Arg Arg Leu Trp Glu Arg 
65                  70                  75                  80  


Val Arg Leu Ser Lys Asn Tyr Glu Lys Ala Leu Glu Gln Ile Asp Glu 
                85                  90                  95      


Asn Leu Ile Tyr Trp Pro Arg Phe Ile Arg His Lys Cys Lys Gln Arg 
            100                 105                 110         


Phe Thr Lys Ile Thr Gln Tyr Leu Ile Arg Ile Arg Lys Leu Thr Leu 
        115                 120                 125             


Lys Arg Gln Arg Lys Leu Val Pro Leu Ser Lys Lys Val Glu Arg Arg 
    130                 135                 140                 


Glu Lys Arg Arg Glu Glu Lys Ala Leu Ile Ala Ala Gln Leu Asp Asn 
145                 150                 155                 160 


Ala Ile Glu Lys Glu Leu Leu Glu Arg Leu Lys Gln Asp Thr Tyr Gly 
                165                 170                 175     


Asp Ile Tyr Asn Phe Pro Ile His Ala Phe Asp Lys Ala Leu Glu Gln 
            180                 185                 190         


Gln Glu Ala Glu Ser Asp Ser Ser Asp Thr Glu Glu Lys Asp Asp Asp 
        195                 200                 205             


Asp Asp Asp Glu Glu Asp Val Gly Lys Arg Glu Phe Val Glu Asp Gly 
    210                 215                 220                 


Glu Val Asp Glu Ser Asp Ile Ser Asp Phe Glu Asp Met Asp Lys Leu 
225                 230                 235                 240 


Asp Ala Ser Ser Asp Glu Asp Gln Asp Gly Lys Ser Ser Ser Glu Glu 
                245                 250                 255     


Glu Glu Glu Lys Ala Leu Ser Ala Lys His Lys Gly Lys Met Pro Leu 
            260                 265                 270         


Arg Gly Pro Leu Gln Arg Lys Arg Ala Tyr Val Glu Ile Glu Tyr Glu 
        275                 280                 285             


Gln Glu Thr Glu Pro Val Ala Lys Ala Lys Thr Thr 
    290                 295                 300 


<210>  2247
<211>  2192
<212>  DNA
<213>  Homosapiens

<400>  2247
ctttaaattt ttaagttttt tttcttttta gtcttcagaa aggcaacagt agtcttttaa     60

cgtcactgtt aaaagtgtaa gactctttta ctccctgaga gtcccctttc cctttcttgc    120

gtcctttcct ctttattctt tttttttttt tttttttttt tactgagacg gagtctcact    180

ctgtcgccca ggctggagtg cagtggcgcg atctcggctc actgcaaact ccgcctcccg    240

ggttcaccct ttctctttat tcttatcccg gtcagactcg ccccctcctc caagacatct    300

ctctgtttta ttttatttga ttttagttct ctttgggtga tcgctccttc cctcttcagc    360

ggatccctcc ccgcctccat cctcgttctg tgggagagac cagccttctg gtgctgcagt    420

caggaatgga gcttgacagc gctctggaag ccccatcgca ggaagactct aatttgtccg    480

aggagttgtc tcactccgcc tttggacagg ccttctccaa gattttacac tgtcttgccc    540

gcccggaggc acgacgaggc aacgtaaaag atgcagttct taaagacctc ggtgatctaa    600

tagaagccac aggatttgat aggttatttg aggggactgg tgcacggctc cgcggaatgc    660

cggagacact ggggcaggta gcaaaagccc tggagaagta tgcagccccc tccaaggagg    720

aggaaggtgg aggtgatggg cactccgaag cggccgagaa agcagcccaa gttgggttac    780

tgtttcttaa actgttaggg aaagttgaga ctgctaagaa ttccctggtc ggccctgcat    840

ggcagacggg cctgcatcac ttggcaggac ccgtttatat ttttgccatc acacacagct    900

tggagcaacc atggaccact ccgagatctc gggaagttgc tagggaggtg ctcacctcac    960

tgcttcaagt tactgaatgc ggttctgtgg caggattcct acatggagaa aatgaagatg   1020

agaaagggag actttcggtg atactagggc ttctcaaacc cgacttgtat aaggaatcct   1080

ggaagaataa ccctgccatc aaacatgttt tctcatggac tctgcaacag gtcactcggc   1140

cctggctgag ccagcatctg gaaagggtac ttcccgcatc attggtcatt tcagatgact   1200

atcagactga gaacaaaatc ctgggtgtac actgtctcca tcacattgtg cttaatgtgc   1260

cagctgctga tttgctccag tataacagag cccaggtcct ataccatgcc atttccaacc   1320

acctgtacac accagagcac cacctcattc aggctgtgct cctgtgtctg ctggatttat   1380

tccccatcct ggagaaaacc ctgcactgga aaggagatgg agctcgaccc accacccatt   1440

gtgatgaggt cctgcggctg atcctgaccc acatggagcc agagcaccgc cttcttttac   1500

gcaggaccta cgcaagaaac ctgccggctt tcgtgaacag gttggggatc ctaactgtcc   1560

ggcacttaaa gaggctggag agagtcatca ttggttatct ggaggtttat gatggacctg   1620

aggaggaagc tagactgaag atattggaaa ccctaaaact tctcatgcaa catacttggc   1680

ccagagtttc ctgcagactt gtggtcttac tgaaggccct cttgaaactg atttgtgatg   1740

tagcaaggga tccaaacctt acacctgagt ctgttaagag cgccctgcta caggaggcca   1800

cagactgcct gattctcctg gaccgccgtt ctcaaggacg ggtaaagggt ctcctggcca   1860

aaattcccca aagctgtgaa gacagaaaag tggtgaacta tatcagaaaa gtgcagcagg   1920

tttctgaagg cgcaccctac aatggaactt aagacttgta ttactttccc aagaggaaag   1980

gattttcttc ccatcccaat ttgtatgaat ggagttattt aagaaaaaaa gatattttta   2040

cacgaaactt tgtaagtgaa agctgctttt tccttccttc tttcctttta cctccataag   2100

aatagggaaa gtagaacaag aaaaaattga actccttcca tttctaaata aagtttggga   2160

gaaaaaagga aaaaaaaaaa aaaaaaaaaa aa                                 2192


<210>  2248
<211>  508
<212>  PRT
<213>  Homosapiens

<400>  2248

Met Glu Leu Asp Ser Ala Leu Glu Ala Pro Ser Gln Glu Asp Ser Asn 
1               5                   10                  15      


Leu Ser Glu Glu Leu Ser His Ser Ala Phe Gly Gln Ala Phe Ser Lys 
            20                  25                  30          


Ile Leu His Cys Leu Ala Arg Pro Glu Ala Arg Arg Gly Asn Val Lys 
        35                  40                  45              


Asp Ala Val Leu Lys Asp Leu Gly Asp Leu Ile Glu Ala Thr Gly Phe 
    50                  55                  60                  


Asp Arg Leu Phe Glu Gly Thr Gly Ala Arg Leu Arg Gly Met Pro Glu 
65                  70                  75                  80  


Thr Leu Gly Gln Val Ala Lys Ala Leu Glu Lys Tyr Ala Ala Pro Ser 
                85                  90                  95      


Lys Glu Glu Glu Gly Gly Gly Asp Gly His Ser Glu Ala Ala Glu Lys 
            100                 105                 110         


Ala Ala Gln Val Gly Leu Leu Phe Leu Lys Leu Leu Gly Lys Val Glu 
        115                 120                 125             


Thr Ala Lys Asn Ser Leu Val Gly Pro Ala Trp Gln Thr Gly Leu His 
    130                 135                 140                 


His Leu Ala Gly Pro Val Tyr Ile Phe Ala Ile Thr His Ser Leu Glu 
145                 150                 155                 160 


Gln Pro Trp Thr Thr Pro Arg Ser Arg Glu Val Ala Arg Glu Val Leu 
                165                 170                 175     


Thr Ser Leu Leu Gln Val Thr Glu Cys Gly Ser Val Ala Gly Phe Leu 
            180                 185                 190         


His Gly Glu Asn Glu Asp Glu Lys Gly Arg Leu Ser Val Ile Leu Gly 
        195                 200                 205             


Leu Leu Lys Pro Asp Leu Tyr Lys Glu Ser Trp Lys Asn Asn Pro Ala 
    210                 215                 220                 


Ile Lys His Val Phe Ser Trp Thr Leu Gln Gln Val Thr Arg Pro Trp 
225                 230                 235                 240 


Leu Ser Gln His Leu Glu Arg Val Leu Pro Ala Ser Leu Val Ile Ser 
                245                 250                 255     


Asp Asp Tyr Gln Thr Glu Asn Lys Ile Leu Gly Val His Cys Leu His 
            260                 265                 270         


His Ile Val Leu Asn Val Pro Ala Ala Asp Leu Leu Gln Tyr Asn Arg 
        275                 280                 285             


Ala Gln Val Leu Tyr His Ala Ile Ser Asn His Leu Tyr Thr Pro Glu 
    290                 295                 300                 


His His Leu Ile Gln Ala Val Leu Leu Cys Leu Leu Asp Leu Phe Pro 
305                 310                 315                 320 


Ile Leu Glu Lys Thr Leu His Trp Lys Gly Asp Gly Ala Arg Pro Thr 
                325                 330                 335     


Thr His Cys Asp Glu Val Leu Arg Leu Ile Leu Thr His Met Glu Pro 
            340                 345                 350         


Glu His Arg Leu Leu Leu Arg Arg Thr Tyr Ala Arg Asn Leu Pro Ala 
        355                 360                 365             


Phe Val Asn Arg Leu Gly Ile Leu Thr Val Arg His Leu Lys Arg Leu 
    370                 375                 380                 


Glu Arg Val Ile Ile Gly Tyr Leu Glu Val Tyr Asp Gly Pro Glu Glu 
385                 390                 395                 400 


Glu Ala Arg Leu Lys Ile Leu Glu Thr Leu Lys Leu Leu Met Gln His 
                405                 410                 415     


Thr Trp Pro Arg Val Ser Cys Arg Leu Val Val Leu Leu Lys Ala Leu 
            420                 425                 430         


Leu Lys Leu Ile Cys Asp Val Ala Arg Asp Pro Asn Leu Thr Pro Glu 
        435                 440                 445             


Ser Val Lys Ser Ala Leu Leu Gln Glu Ala Thr Asp Cys Leu Ile Leu 
    450                 455                 460                 


Leu Asp Arg Arg Ser Gln Gly Arg Val Lys Gly Leu Leu Ala Lys Ile 
465                 470                 475                 480 


Pro Gln Ser Cys Glu Asp Arg Lys Val Val Asn Tyr Ile Arg Lys Val 
                485                 490                 495     


Gln Gln Val Ser Glu Gly Ala Pro Tyr Asn Gly Thr 
            500                 505             


<210>  2249
<211>  1868
<212>  DNA
<213>  Homosapiens

<400>  2249
agtttcggaa ccccagccag ctcacctctg cgccgctgaa cccgatccga gcctccggca     60

aaggtttttc cctcctcccc cggccgaggg cttctgcagc ccgggcaccc ccgccccgcg    120

gcgccccaca ttcccccagc ccggggccct tggcgcgtgc gctccgtgcg gctgtgctcc    180

gcgggacttt gtttgtttcc tcctcgtccc tctttgttgg gctgaacacc agcctcgtca    240

aagcccccca ctccggaggg agttcggctt ctccagcagg gcggctgcag cgcgctgccc    300

cgaccccgcc tgcggcccct cacgccgcta gtgctcccac cccgccctcc tggcaccccg    360

cctgcgtccg ttcgcccgag gaagccaacc gcgacttcat tgatgcaccc attccagtgg    420

tgtaacgggt gtttctgtgg cctgggactg gttagcacca acaagtcctg ctcgatgcca    480

cccatcagtt tccaggacct tccgctcaac atctatatgg tcatcttcgg cacaggcatc    540

tttgtcttca tgctcagcct tatcttctgc tgctatttta tcagcaaact gcggaaccag    600

gcacagagtg agcgatacgg atataaggag gtggtgctta aaggtgatgc caagaagtta    660

caattatatg ggcagacctg cgcagtctgt ctggaagact tcaaggggaa ggatgagtta    720

ggcgtgctcc cgtgccaaca cgcctttcac cgcaagtgtc tggtgaaatg gctggaagtt    780

cgctgtgtct gccccatgtg taacaagccc attgctagtc cctcagaggc cacgcagaac    840

attgggattc tattggatga gctggtgtga gtgctgccgc tacaccgaga cctggagaag    900

acctcttgcc tcatggatgt ctggtccctc tgcacagctc caaccaacag gactgtaggg    960

tgatgacgat cactttccca gtgatgagaa gggtggtcta ggactgggct tctaccctca   1020

gtgcaagacc agtgccagat gtgcccccac ttcctgcctc ctgaagcctt cttccctgct   1080

actccatgct ggtggcctca cccatcaaga ccactgtctc ctggtactgg actatctacc   1140

tgccttgtcc ctgttctggg ggaaggtgtc caccccgatc aagaacatgg agaaagtcct   1200

ctttcaaggc tcccattagg aggatgagct gccttgaccc agaagggatg agacgggctc   1260

ttacctctct acaaccttcc ctccccttcc cactccttcc ggagtaaggt tagaagggaa   1320

ggaaggaaag atcaaggaac caagcgcctc cacgggaggc gagggaggct ctgtatgaaa   1380

cagaagagca gggacataaa ggaaaatgtc agtgtttaca tgggacctat ggaaacaaag   1440

gctggcgggc gccagctgac tccagagtaa gagagggccc ttcccctgcc aggacccacg   1500

gtgctatcca ttcagtctct tcctcagtta atctcggagc ttcctattcc atgttgaggt   1560

ttgtgggccc ctctagagga gggctagttc tatacttaaa ttgattccca ggggcctttt   1620

tttttttttt tttttttttt ttgatcaaaa ggggtgtggg gatgggggtg tctacggtta   1680

agcaacagat acctccttcc ctttgtaaat agtattttta tacttcatcc tcgcctctca   1740

ggctttagat acgaaatctc cagaatggaa gggggtgggg attttctgtt cctccctgga   1800

gtgggtgagg gtgggagaaa gttacatatt taaagaaaaa taaatttaat aacaagtttc   1860

tctaacct                                                            1868


<210>  2250
<211>  155
<212>  PRT
<213>  Homosapiens

<400>  2250

Met His Pro Phe Gln Trp Cys Asn Gly Cys Phe Cys Gly Leu Gly Leu 
1               5                   10                  15      


Val Ser Thr Asn Lys Ser Cys Ser Met Pro Pro Ile Ser Phe Gln Asp 
            20                  25                  30          


Leu Pro Leu Asn Ile Tyr Met Val Ile Phe Gly Thr Gly Ile Phe Val 
        35                  40                  45              


Phe Met Leu Ser Leu Ile Phe Cys Cys Tyr Phe Ile Ser Lys Leu Arg 
    50                  55                  60                  


Asn Gln Ala Gln Ser Glu Arg Tyr Gly Tyr Lys Glu Val Val Leu Lys 
65                  70                  75                  80  


Gly Asp Ala Lys Lys Leu Gln Leu Tyr Gly Gln Thr Cys Ala Val Cys 
                85                  90                  95      


Leu Glu Asp Phe Lys Gly Lys Asp Glu Leu Gly Val Leu Pro Cys Gln 
            100                 105                 110         


His Ala Phe His Arg Lys Cys Leu Val Lys Trp Leu Glu Val Arg Cys 
        115                 120                 125             


Val Cys Pro Met Cys Asn Lys Pro Ile Ala Ser Pro Ser Glu Ala Thr 
    130                 135                 140                 


Gln Asn Ile Gly Ile Leu Leu Asp Glu Leu Val 
145                 150                 155 


<210>  2251
<211>  1665
<212>  DNA
<213>  Homosapiens

<400>  2251
gttggctggg gagcccacgc tgcctggcga ctcgggccac cgaatgtgag accgagtccc     60

tttatgtcac cagcgcacac gctgatttga accctgcttc gacgtgtgtg tcatggctta    120

aaaatagctg ctaatctgtc aacctgtctt gggcagaaac agcggcggcg acagcagcag    180

gagcgtcatg gccgtggcgc tgtctgcgcc ggcgatccgc ctttcggact gaggcccagc    240

gcagcgcttg caaagagcag cagctacctg gcaactgaac ccatcatcac cacagccact    300

cctgcagctg ccacggtttc tgccacctct aagatgtgcc ctggtaactg gctttgggct    360

tctatgactt ttatggcccg cttctcccgg agtagctcaa ggtctcctgt tcgaactcga    420

gggaccctgg aggagatgcc aaccgttcaa catcctttcc tcaatgtctt cgagttggag    480

cggctcctct acacaggcaa gacagcctgt aaccatgccg acgaggtctg gccaggcctc    540

tatctcggag accaggacat ggctaacaac cgccgggagc ttcgccgcct gggcatcacg    600

cacgtcctca atgcctcaca cagccggtgg cgaggcacgc ccgaggccta tgaggggctg    660

ggcatccgct acctgggtgt tgaggcccac gactcgccag cctttgacat gagcatccac    720

ttccagacgg ctgccgactt catccaccgg gcgctgagcc agccaggagg gaagatcctg    780

gtgcattgtg ctgtgggcgt gagccgatcc gccaccctgg tactggccta cctcatgctg    840

taccaccacc ttaccctcgt ggaggccatc aagaaagtca aagaccaccg aggcatcatc    900

cccaaccggg gcttcctgag gcagctcctg gccctggacc gcaggctgcg gcagggtctg    960

gaagcatgag gggaggggga gagaggtcag gccaggcccg tgggtaggtc cctggctccc   1020

agctggagat aggaggccca ggtggcaggt agcaggaggc ccagatcacc catcctcccc   1080

tggggtcagg agaggccgag ccccaggcca ctgtcactct ttgtgggagg ggacggggag   1140

tgaggttggg cagtgtggtg gatgggcacc caggaagggt tgaccaggga aggaggcagc   1200

taggctgtag atggaagatg gtcctgggat tcgaacaccg ctgggatctg gccagggtgc   1260

tccctgggat tcacagtccc ttcccctctt tgtgcccaag tgtttccctc tctccctcac   1320

caaaacaaaa gggccatctc tgccctgcac ttgtgcagaa agtcagggat acggcaagca   1380

tgaatgcaat ggtgtagagt tgtgtgaaac ccctagcata gagacagaca gcgaagagat   1440

ggtgtgaaaa gcttgcagaa ccagacagag aaccccacag actttccact ccaagcacag   1500

gaggaggtag ctagcgtgtg agggttggca ctaggcccac ggctgctgct tgggccaaaa   1560

acatacagag gtgcatggct ggcagtcttg aaattgtcac tcgcttactg gatccaagcg   1620

tctcgaggat aaataaagat catgaaaaaa aaaaaaaaaa aaaaa                   1665


<210>  2252
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  2252

Met Cys Pro Gly Asn Trp Leu Trp Ala Ser Met Thr Phe Met Ala Arg 
1               5                   10                  15      


Phe Ser Arg Ser Ser Ser Arg Ser Pro Val Arg Thr Arg Gly Thr Leu 
            20                  25                  30          


Glu Glu Met Pro Thr Val Gln His Pro Phe Leu Asn Val Phe Glu Leu 
        35                  40                  45              


Glu Arg Leu Leu Tyr Thr Gly Lys Thr Ala Cys Asn His Ala Asp Glu 
    50                  55                  60                  


Val Trp Pro Gly Leu Tyr Leu Gly Asp Gln Asp Met Ala Asn Asn Arg 
65                  70                  75                  80  


Arg Glu Leu Arg Arg Leu Gly Ile Thr His Val Leu Asn Ala Ser His 
                85                  90                  95      


Ser Arg Trp Arg Gly Thr Pro Glu Ala Tyr Glu Gly Leu Gly Ile Arg 
            100                 105                 110         


Tyr Leu Gly Val Glu Ala His Asp Ser Pro Ala Phe Asp Met Ser Ile 
        115                 120                 125             


His Phe Gln Thr Ala Ala Asp Phe Ile His Arg Ala Leu Ser Gln Pro 
    130                 135                 140                 


Gly Gly Lys Ile Leu Val His Cys Ala Val Gly Val Ser Arg Ser Ala 
145                 150                 155                 160 


Thr Leu Val Leu Ala Tyr Leu Met Leu Tyr His His Leu Thr Leu Val 
                165                 170                 175     


Glu Ala Ile Lys Lys Val Lys Asp His Arg Gly Ile Ile Pro Asn Arg 
            180                 185                 190         


Gly Phe Leu Arg Gln Leu Leu Ala Leu Asp Arg Arg Leu Arg Gln Gly 
        195                 200                 205             


Leu Glu Ala 
    210     


<210>  2253
<211>  1488
<212>  DNA
<213>  Homosapiens

<400>  2253
ggggagaatg atttcactac agactctctg gaaagcctgg gagctgaatt ccggaagatc     60

cccacatcga tgaaagcaaa gcgaagccac caagccatca tcatgtccac gtcgctacga    120

gtcagcccat ccatccatgg ctaccacttc gacacagcct ctcgtaagaa agccgtgggc    180

aacatctttg aaaacacaga ccaagaatca ctagaaaggc tcttcagaaa ctctggagac    240

aagaaagcag aggagagagc caagatcatt tttgccatag atcaagatgt ggaggagaaa    300

acgcgtgccc tgatggcctt gaagaagagg acaaaagaca agcttttcca gtttctgaaa    360

ctgcggaaat attccatcaa agttcactga agagaagagg atggataagg acgttatcca    420

agaatggaca ttcaaagacc aagtgagttt gtgagattct aacagatgca gcattttgct    480

gctaccttac aagcttctct tctgtcagga ctccagaggc tggaaaggga ccgggactgg    540

aaagggacca ggactgaaca gactggttac aaagactcca aacaatttca tgccctgtgc    600

tgttacagag gagaacaaaa tgctttcagc aaggatttga aaactcttcc gtccctgcag    660

gaaaggattg atgctgatag aagagcctgg acagatgtaa tgagaactaa agaaaacaga    720

tggctggaga tgacatttat ccagggtcac tttgtcaggc cctaggactt aaatcgaagt    780

tgaacttttt tttttttttt aaccaaatag ataggggaag ggaggaggga gagggaggac    840

agggagagaa aataccatgc ataaattgtt tactgaattt ttatatctga gtgttcaaaa    900

tatttccaag cctgagtatt gtctattggt atagattttt agaaatcaat aattgattat    960

ttatttgcac ttattacaat gcctgaaaaa gtgcaccaca tggatgttaa gtagaaattc   1020

aagaaagtaa gatgtcttca gcaactcagt aaaaccttac gccacctttt ggtttgtaaa   1080

aggtttttta tacatttcaa acaggttgca caaaagttaa aataatgggg tcttttataa   1140

atccaaagta ctgtgaaaac attttacata ttttttaaat cttctgacta atgctaaaac   1200

gtaatctaat taaatttcat acagttactg cagtaagcat taggaagtga atatgatata   1260

caaaatagtt tataaagact ctatagtttc tataatttat tttactggca aatgtcatgc   1320

aacaataata aattattgta aactttgtgg cttttggtct gtgatgcttg gtctcaaagg   1380

aaaaaataag atggtaaatg ttgatattta caaacttttc taaagatgtg tctctaacaa   1440

taaaagttaa ttttagagta aaaaaaaaaa aaaaaaaaaa aaaaaaaa                1488


<210>  2254
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  2254

Met Lys Ala Lys Arg Ser His Gln Ala Ile Ile Met Ser Thr Ser Leu 
1               5                   10                  15      


Arg Val Ser Pro Ser Ile His Gly Tyr His Phe Asp Thr Ala Ser Arg 
            20                  25                  30          


Lys Lys Ala Val Gly Asn Ile Phe Glu Asn Thr Asp Gln Glu Ser Leu 
        35                  40                  45              


Glu Arg Leu Phe Arg Asn Ser Gly Asp Lys Lys Ala Glu Glu Arg Ala 
    50                  55                  60                  


Lys Ile Ile Phe Ala Ile Asp Gln Asp Val Glu Glu Lys Thr Arg Ala 
65                  70                  75                  80  


Leu Met Ala Leu Lys Lys Arg Thr Lys Asp Lys Leu Phe Gln Phe Leu 
                85                  90                  95      


Lys Leu Arg Lys Tyr Ser Ile Lys Val His 
            100                 105     


<210>  2255
<211>  4465
<212>  DNA
<213>  Homosapiens

<400>  2255
cctgcagcct ccggagtcag tgccgcgcgc ccgccgcccc gcgccttcct gctcgccgca     60

cctccgggag ccggggcgca cccagcccgc agcgccgcct ccccgcccgc gccgcctccg    120

accgcaggcc gagggccgcc actggccggg gggaccgggc agcagcttgc ggccgcggag    180

ccgggcaacg ctggggactg cgccttttgt ccccggaggt ccctggaagt ttgcggcagg    240

acgcgcgcgg ggaggcggcg gaggcagccc cgacgtcgcg gagaacaggg cgcagagccg    300

gcatgggcat cgggcgcagc gaggggggcc gccgcggggc agccctgggc gtgctgctgg    360

cgctgggcgc ggcgcttctg gccgtgggct cggccagcga gtacgactac gtgagcttcc    420

agtcggacat cggcccgtac cagagcgggc gcttctacac caagccacct cagtgcgtgg    480

acatccccgc ggacctgcgg ctgtgccaca acgtgggcta caagaagatg gtgctgccca    540

acctgctgga gcacgagacc atggcggagg tgaagcagca ggccagcagc tgggtgcccc    600

tgctcaacaa gaactgccac gccggcaccc aggtcttcct ctgctcgctc ttcgcgcccg    660

tctgcctgga ccggcccatc tacccgtgtc gctggctctg cgaggccgtg cgcgactcgt    720

gcgagccggt catgcagttc ttcggcttct actggcccga gatgcttaag tgtgacaagt    780

tccccgaggg ggacgtctgc atcgccatga cgccgcccaa tgccaccgaa gcctccaagc    840

cccaaggcac aacggtgtgt cctccctgtg acaacgagtt gaaatctgag gccatcattg    900

aacatctctg tgccagcgag tttgcactga ggatgaaaat aaaagaagtg aaaaaagaaa    960

atggcgacaa gaagattgtc cccaagaaga agaagcccct gaagttgggg cccatcaaga   1020

agaaggacct gaagaagctt gtgctgtacc tgaagaatgg ggctgactgt ccctgccacc   1080

agctggacaa cctcagccac cacttcctca tcatgggccg caaggtgaag agccagtact   1140

tgctgacggc catccacaag tgggacaaga aaaacaagga gttcaaaaac ttcatgaaga   1200

aaatgaaaaa ccatgagtgc cccacctttc agtccgtgtt taagtgattc tcccgggggc   1260

agggtgggga gggagcctcg ggtggggtgg gagcgggggg gacagtgccc cgggaacccg   1320

gtgggtcaca cacacgcact gcgcctgtca gtagtggaca ttgtaatcca gtcggcttgt   1380

tcttgcagca ttcccgctcc cttccctcca tagccacgct ccaaacccca gggtagccat   1440

ggccgggtaa agcaagggcc atttagatta ggaaggtttt taagatccgc aatgtggagc   1500

agcagccact gcacaggagg aggtgacaaa ccatttccaa cagcaacaca gccactaaaa   1560

cacaaaaagg gggattgggc ggaaagtgag agccagcagc aaaaactaca ttttgcaact   1620

tgttggtgtg gatctattgg ctgatctatg cctttcaact agaaaattct aatgattggc   1680

aagtcacgtt gttttcaggt ccagagtagt ttctttctgt ctgctttaaa tggaaacaga   1740

ctcataccac acttacaatt aaggtcaagc ccagaaagtg ataagtgcag ggaggaaaag   1800

tgcaagtcca ttatgtaata gtgacagcaa agggaccagg ggagaggcat tgccttctct   1860

gcccacagtc tttccgtgtg attgtctttg aatctgaatc agccagtctc agatgcccca   1920

aagtttcggt tcctatgagc ccggggcatg atctgatccc caagacatgt ggaggggcag   1980

cctgtgcctg cctttgtgtc agaaaaagga aaccacagtg agcctgagag agacggcgat   2040

tttcgggctg agaaggcagt agttttcaaa acacatagtt aaaaaagaaa caaatgaaaa   2100

aaattttaga acagtccagc aaattgctag tcagggtgaa ttgtgaaatt gggtgaagag   2160

cttaggattc taatctcatg ttttttcctt ttcacatttt taaaagaaca atgacaaaca   2220

cccacttatt tttcaaggtt ttaaaacagt ctacattgag catttgaaag gtgtgctaga   2280

acaaggtctc ctgatccgtc cgaggctgct tcccagagga gcagctctcc ccaggcattt   2340

gccaagggag gcggatttcc ctggtagtgt agctgtgtgg ctttccttcc tgaagagtcc   2400

gtggttgccc tagaacctaa caccccctag caaaactcac agagctttcc gtttttttct   2460

ttcctgtaaa gaaacatttc ctttgaactt gattgcctat ggatcaaaga aattcagaac   2520

agcctgcctg tccccccgca ctttttacat atatttgttt catttctgca gatggaaagt   2580

tgacatgggt ggggtgtccc catccagcga gagagtttca aaagcaaaac atctctgcag   2640

tttttcccaa gtaccctgag atacttccca aagcccttat gtttaatcag cgatgtatat   2700

aagccagttc acttagacaa ctttaccctt cttgtccaat gtacaggaag tagttctaaa   2760

aaaaatgcat attaatttct tcccccaaag ccggattctt aattctctgc aacactttga   2820

ggacatttat gattgtccct ctgggccaat gcttataccc agtgaggatg ctgcagtgag   2880

gctgtaaagt ggccccctgc ggccctagcc tgacccggag gaaaggatgg tagattctgt   2940

taactcttga agactccagt atgaaaatca gcatgcccgc ctagttacct accggagagt   3000

tatcctgata aattaacctc tcacagttag tgatcctgtc cttttaacac cttttttgtg   3060

gggttctctc tgacctttca tcgtaaagtg ctggggacct taagtgattt gcctgtaatt   3120

ttggatgatt aaaaaatgtg tatatatatt agctaattag aaatattcta cttctctgtt   3180

gtcaaactga aattcagagc aagttcctga gtgcgtggat ctgggtctta gttctggttg   3240

attcactcaa gagttcagtg ctcatacgta tctgctcatt ttgacaaagt gcctcatgca   3300

accgggccct ctctctgcgg cagagtcctt agtggagggg tttacctgga acattagtag   3360

ttaccacaga atacggaaga gcaggtgact gtgctgtgca gctctctaaa tgggaattct   3420

caggtaggaa gcaacagctt cagaaagagc tcaaaataaa ttggaaatgt gaatcgcagc   3480

tgtgggtttt accaccgtct gtctcagagt cccaggacct tgagtgtcat tagttacttt   3540

attgaaggtt ttagacccat agcagctttg tctctgtcac atcagcaatt tcagaaccaa   3600

aagggaggct ctctgtaggc acagagctgc actatcacga gcctttgttt ttctccacaa   3660

agtatctaac aaaaccaatg tgcagactga ttggcctggt cattggtctc cgagagagga   3720

ggtttgcctg tgatttccta attatcgcta gggccaaggt gggatttgta aagctttaca   3780

ataatcattc tggatagagt cctgggaggt ccttggcaga actcagttaa atctttgaag   3840

aatatttgta gttatcttag aagatagcat gggaggtgag gattccaaaa acattttatt   3900

tttaaaatat cctgtgtaac acttggctct tggtacctgt gggttagcat caagttctcc   3960

ccagggtaga attcaatcag agctccagtt tgcatttgga tgtgtaaatt acagtaatcc   4020

catttcccaa acctaaaatc tgtttttctc atcagactct gagtaactgg ttgctgtgtc   4080

ataacttcat agatgcagga ggctcaggtg atctgtttga ggagagcacc ctaggcagcc   4140

tgcagggaat aacatactgg ccgttctgac ctgttgccag cagatacaca ggacatggat   4200

gaaattcccg tttcctctag tttcttcctg tagtactcct cttttagatc ctaagtctct   4260

tacaaaagct ttgaatactg tgaaaatgtt ttacattcca tttcatttgt gttgtttttt   4320

taactgcatt ttaccagatg ttttgatgtt atcgcttatg ttaatagtaa ttcccgtacg   4380

tgttcatttt attttcatgc tttttcagcc atgtatcaat attcacttga ctaaaatcac   4440

tcaattaatc aatgaaaaaa aaaaa                                         4465


<210>  2256
<211>  314
<212>  PRT
<213>  Homosapiens

<400>  2256

Met Gly Ile Gly Arg Ser Glu Gly Gly Arg Arg Gly Ala Ala Leu Gly 
1               5                   10                  15      


Val Leu Leu Ala Leu Gly Ala Ala Leu Leu Ala Val Gly Ser Ala Ser 
            20                  25                  30          


Glu Tyr Asp Tyr Val Ser Phe Gln Ser Asp Ile Gly Pro Tyr Gln Ser 
        35                  40                  45              


Gly Arg Phe Tyr Thr Lys Pro Pro Gln Cys Val Asp Ile Pro Ala Asp 
    50                  55                  60                  


Leu Arg Leu Cys His Asn Val Gly Tyr Lys Lys Met Val Leu Pro Asn 
65                  70                  75                  80  


Leu Leu Glu His Glu Thr Met Ala Glu Val Lys Gln Gln Ala Ser Ser 
                85                  90                  95      


Trp Val Pro Leu Leu Asn Lys Asn Cys His Ala Gly Thr Gln Val Phe 
            100                 105                 110         


Leu Cys Ser Leu Phe Ala Pro Val Cys Leu Asp Arg Pro Ile Tyr Pro 
        115                 120                 125             


Cys Arg Trp Leu Cys Glu Ala Val Arg Asp Ser Cys Glu Pro Val Met 
    130                 135                 140                 


Gln Phe Phe Gly Phe Tyr Trp Pro Glu Met Leu Lys Cys Asp Lys Phe 
145                 150                 155                 160 


Pro Glu Gly Asp Val Cys Ile Ala Met Thr Pro Pro Asn Ala Thr Glu 
                165                 170                 175     


Ala Ser Lys Pro Gln Gly Thr Thr Val Cys Pro Pro Cys Asp Asn Glu 
            180                 185                 190         


Leu Lys Ser Glu Ala Ile Ile Glu His Leu Cys Ala Ser Glu Phe Ala 
        195                 200                 205             


Leu Arg Met Lys Ile Lys Glu Val Lys Lys Glu Asn Gly Asp Lys Lys 
    210                 215                 220                 


Ile Val Pro Lys Lys Lys Lys Pro Leu Lys Leu Gly Pro Ile Lys Lys 
225                 230                 235                 240 


Lys Asp Leu Lys Lys Leu Val Leu Tyr Leu Lys Asn Gly Ala Asp Cys 
                245                 250                 255     


Pro Cys His Gln Leu Asp Asn Leu Ser His His Phe Leu Ile Met Gly 
            260                 265                 270         


Arg Lys Val Lys Ser Gln Tyr Leu Leu Thr Ala Ile His Lys Trp Asp 
        275                 280                 285             


Lys Lys Asn Lys Glu Phe Lys Asn Phe Met Lys Lys Met Lys Asn His 
    290                 295                 300                 


Glu Cys Pro Thr Phe Gln Ser Val Phe Lys 
305                 310                 


<210>  2257
<211>  2042
<212>  DNA
<213>  Homosapiens

<400>  2257
cgcggggcct gggccaggcg gcagctaagg cccgcggtga cagcatgggt gaaggggagc     60

ggggcagagg aggccttggg ctgttttcgg cggcgggtgg gggcgagggg ctggcgggtc    120

agagtcccgg gtccaggccg gggctctgac tcgcggttgg tgttcccccg accccgcagc    180

gcggggtgtc ctgtcctcgc catgaggccg cagcaggcgc cggtgtccgg aaaggtgttc    240

attcagcgag actacagcag tggcacacgc tgccagttcc agaccaagtt ccctgcggag    300

ctggagaacc ggattgatag gcagcagttt gaagaaacag ttcgaactct aaataacctt    360

tatgcagaag cagagaagct cggcggccag tcatatctcg aaggttgttt ggcttgttta    420

acagcatata ccatcttcct atgcatggaa actcattatg agaaggttct gaagaaagtc    480

tccaaataca ttcaagagca gaatgagaag atctatgctc cacaaggcct cctcctgaca    540

gaccctattg agcgaggact gcgagttatt gaaattacca tttatgaaga cagaggcatg    600

agcagtggaa gataaaccga agaattaaag atcccacttc cagccgggcc cctcatgtat    660

ccactggccg accgcagagt gtccctacct cctctccaga gcatcattcc tttctatctg    720

ctgccagagc cacggtgcca tttactccaa ggactcactt tctaaaattc cacacctgga    780

gtgacctcta gtcgctcagc atccactttg tgtctccaaa ttgtgtagga ctctgtaatc    840

ttttgattag tttctgagaa aacacaatga agcacttcac ttttttttat tcaaagccat    900

ttaataaaac acagttggtc agcccagtgc aaagcttgtt atctgccacc agtacatacc    960

attggttctc ttcattcctt gggccagctt ctcaggtggc tttagacctc aacaagccgt   1020

atcttcacca gtgttctatc ttgttcccct aaattaataa aatgtttttc tccaggattt   1080

tggtgagggt tggctgtggc tgtcgttttg cacctcccag atttcaaaga attactggtt   1140

ttaccatgac tcaaatctta agatctgttt ctactattca gttcctcaaa ctgaagctta   1200

ttgaaaaaaa aatgtataat gttatttgtt ttattatagc aattatgcct aattaaagca   1260

gtatttaatg caatttccag ttatttcttt ggagaatttt atgtcattgt tccattacct   1320

tgaatgttgg aaagatatga tacgtgctgc ttgttcatca caaaaatcag taagcacaat   1380

aaagtggatg ccaaaccatc agacacataa atgttcccgc tgtgtccctg gatatggaat   1440

aagcaggtat aaaaaatatt ttaattatag ttttgttata aatataactt atgagaaaaa   1500

aatttgatag gaataatact gtatattact aatttttaac tatccctaag gcaaacctta   1560

tgacccacag aattttctca tatacagtat tcagtgcaca gaaatcttat gattggctca   1620

agtacagtaa gttacttctc agtaaaactc tcaagtctga gtccatattt gtagctctgc   1680

ttttggctgt acgttcctag gatcggggct gcttatgcct ttcgtttatc cttggggttt   1740

gagagcgctg tatttgggag agagtttaaa aatacattag gagagagaaa ccattaaaag   1800

tttcactgtc agatatattg taggtgctaa tactggattt cgtctcagat ttaatttctt   1860

ttatgggtct gttagtcatt caacaaatcc cataagtatg tgttaatatt ttaattgtgt   1920

aaaactcatt tgttacttta cagcctgtaa tagtgtgtct gcattttcaa cctgttgcaa   1980

taactttgct gaaatattaa cacattaata aaacttttct taaacaaaaa aaaaaaaaaa   2040

aa                                                                  2042


<210>  2258
<211>  137
<212>  PRT
<213>  Homosapiens

<400>  2258

Met Arg Pro Gln Gln Ala Pro Val Ser Gly Lys Val Phe Ile Gln Arg 
1               5                   10                  15      


Asp Tyr Ser Ser Gly Thr Arg Cys Gln Phe Gln Thr Lys Phe Pro Ala 
            20                  25                  30          


Glu Leu Glu Asn Arg Ile Asp Arg Gln Gln Phe Glu Glu Thr Val Arg 
        35                  40                  45              


Thr Leu Asn Asn Leu Tyr Ala Glu Ala Glu Lys Leu Gly Gly Gln Ser 
    50                  55                  60                  


Tyr Leu Glu Gly Cys Leu Ala Cys Leu Thr Ala Tyr Thr Ile Phe Leu 
65                  70                  75                  80  


Cys Met Glu Thr His Tyr Glu Lys Val Leu Lys Lys Val Ser Lys Tyr 
                85                  90                  95      


Ile Gln Glu Gln Asn Glu Lys Ile Tyr Ala Pro Gln Gly Leu Leu Leu 
            100                 105                 110         


Thr Asp Pro Ile Glu Arg Gly Leu Arg Val Ile Glu Ile Thr Ile Tyr 
        115                 120                 125             


Glu Asp Arg Gly Met Ser Ser Gly Arg 
    130                 135         


<210>  2259
<211>  1919
<212>  DNA
<213>  Homosapiens

<400>  2259
aggacgtaag tgacggcgaa ggcggtgcga cagcagctgg agggcagagg aggcggcgcg     60

gggtgtcctg tcctcgccat gaggccgcag caggcgccgg tgtccggaaa ggtgttcatt    120

cagcgagact acagcagtgg cacacgctgc cagttccaga ccaagttccc tgcggagctg    180

gagaaccgga ttgataggca gcagtttgaa gaaacagttc gaactctaaa taacctttat    240

gcagaagcag agaagctcgg cggccagtca tatctcgaag gttgtttggc ttgtttaaca    300

gcatatacca tcttcctatg catggaaact cattatgaga aggttctgaa gaaagtctcc    360

aaatacattc aagagcagaa tgagaagatc tatgctccac aaggcctcct cctgacagac    420

cctattgagc gaggactgcg agttattgaa attaccattt atgaagacag aggcatgagc    480

agtggaagat aaaccgaaga attaaagatc ccacttccag ccgggcccct catgtatcca    540

ctggccgacc gcagagtgtc cctacctcct ctccagagca tcattccttt ctatctgctg    600

ccagagccac ggtgccattt actccaagga ctcactttct aaaattccac acctggagtg    660

acctctagtc gctcagcatc cactttgtgt ctccaaattg tgtaggactc tgtaatcttt    720

tgattagttt ctgagaaaac acaatgaagc acttcacttt tttttattca aagccattta    780

ataaaacaca gttggtcagc ccagtgcaaa gcttgttatc tgccaccagt acataccatt    840

ggttctcttc attccttggg ccagcttctc aggtggcttt agacctcaac aagccgtatc    900

ttcaccagtg ttctatcttg ttcccctaaa ttaataaaat gtttttctcc aggattttgg    960

tgagggttgg ctgtggctgt cgttttgcac ctcccagatt tcaaagaatt actggtttta   1020

ccatgactca aatcttaaga tctgtttcta ctattcagtt cctcaaactg aagcttattg   1080

aaaaaaaaat gtataatgtt atttgtttta ttatagcaat tatgcctaat taaagcagta   1140

tttaatgcaa tttccagtta tttctttgga gaattttatg tcattgttcc attaccttga   1200

atgttggaaa gatatgatac gtgctgcttg ttcatcacaa aaatcagtaa gcacaataaa   1260

gtggatgcca aaccatcaga cacataaatg ttcccgctgt gtccctggat atggaataag   1320

caggtataaa aaatatttta attatagttt tgttataaat ataacttatg agaaaaaaat   1380

ttgataggaa taatactgta tattactaat ttttaactat ccctaaggca aaccttatga   1440

cccacagaat tttctcatat acagtattca gtgcacagaa atcttatgat tggctcaagt   1500

acagtaagtt acttctcagt aaaactctca agtctgagtc catatttgta gctctgcttt   1560

tggctgtacg ttcctaggat cggggctgct tatgcctttc gtttatcctt ggggtttgag   1620

agcgctgtat ttgggagaga gtttaaaaat acattaggag agagaaacca ttaaaagttt   1680

cactgtcaga tatattgtag gtgctaatac tggatttcgt ctcagattta atttctttta   1740

tgggtctgtt agtcattcaa caaatcccat aagtatgtgt taatatttta attgtgtaaa   1800

actcatttgt tactttacag cctgtaatag tgtgtctgca ttttcaacct gttgcaataa   1860

ctttgctgaa atattaacac attaataaaa cttttcttaa acaaaaaaaa aaaaaaaaa    1919


<210>  2260
<211>  137
<212>  PRT
<213>  Homosapiens

<400>  2260

Met Arg Pro Gln Gln Ala Pro Val Ser Gly Lys Val Phe Ile Gln Arg 
1               5                   10                  15      


Asp Tyr Ser Ser Gly Thr Arg Cys Gln Phe Gln Thr Lys Phe Pro Ala 
            20                  25                  30          


Glu Leu Glu Asn Arg Ile Asp Arg Gln Gln Phe Glu Glu Thr Val Arg 
        35                  40                  45              


Thr Leu Asn Asn Leu Tyr Ala Glu Ala Glu Lys Leu Gly Gly Gln Ser 
    50                  55                  60                  


Tyr Leu Glu Gly Cys Leu Ala Cys Leu Thr Ala Tyr Thr Ile Phe Leu 
65                  70                  75                  80  


Cys Met Glu Thr His Tyr Glu Lys Val Leu Lys Lys Val Ser Lys Tyr 
                85                  90                  95      


Ile Gln Glu Gln Asn Glu Lys Ile Tyr Ala Pro Gln Gly Leu Leu Leu 
            100                 105                 110         


Thr Asp Pro Ile Glu Arg Gly Leu Arg Val Ile Glu Ile Thr Ile Tyr 
        115                 120                 125             


Glu Asp Arg Gly Met Ser Ser Gly Arg 
    130                 135         


<210>  2261
<211>  2165
<212>  DNA
<213>  Homosapiens

<400>  2261
acgtgaccgg cgcctctgtc attctactgc ggccgccctg gcttccttct acctgtgcgg     60

ccctcaacgt ctccttggtg cgggacccgc ttcactttcg gctcccggag tctccctcca    120

ctgctcagac ctctggacct gacaggagac gcctacttgg ctctgacgcg gcgccccagc    180

ccggctgtgt ccccggcgcc ccggaccacc ctccctgccg gctttgggtg cgttgtgggg    240

tcccgaggat tcgcgagatt tgttgaaaga cattcaagat tacgaagttt agatgaccaa    300

aatggatatc cgaggtgctg tggatgctgc tgtccccacc aatattattg ctgccaaggc    360

tgcagaagtt cgtgcaaaca aagtcaactg gcaatcctat cttcagggac agatgatttc    420

tgctgaagat tgtgagttta ttcagaggtt tgaaatgaaa cgaagccctg aagagaagca    480

agagatgctt caaactgaag gcagccagtg tgctaaaaca tttataaatc tgatgactca    540

tatctgcaaa gaacagaccg ttcagtatat actaactatg gtggatgata tgctgcagga    600

aaatcatcag cgtgttagca ttttctttga ctatgcaaga tgtagcaaga acactgcgtg    660

gccctacttt ctgccaatgt tgaatcgcca ggatcccttc actgttcata tggcagcaag    720

aattattgcc aagttagcag cttggggaaa agaactgatg gaaggcagtg acttaaatta    780

ctatttcaat tggataaaaa ctcagctgag ttcacagaaa ctgcgtggta gcggtgttgc    840

tgttgaaaca ggaacagtct cttcaagtga tagttcgcag tatgtgcagt gcgtggccgg    900

gtgtttgcag ctgatgctcc gggtcaatga gtaccgcttt gcttgggtgg aagcagatgg    960

ggtaaattgc ataatgggag tgttgagtaa caagtgtggc tttcagctcc agtatcaaat   1020

gattttttca atatggctcc tggcattcag tcctcaaatg tgtgaacacc tgcggcgcta   1080

taatatcatt ccagttctgt ctgatatcct tcaggagtct gtcaaagaga aagtaacaag   1140

aatcattctt gcagcatttc gtaacttttt agaaaaatca actgaaagag aaactcgcca   1200

agaatatgcc ctggctatga ttcagtgcaa agttctgaaa cagttggaga acttggaaca   1260

gcagaagtac gatgatgaag atatcagcga agatatcaaa tttcttttgg aaaaacttgg   1320

agagagtgtc caggacctta gttcatttga tgaatacagt tcagaactta aatctggaag   1380

gttggaatgg agtcctgtgc acaaatctga gaaattttgg agagagaatg ctgtgaggtt   1440

aaatgagaag aattatgaac tcttgaaaat cttgacaaaa cttttggaag tgtcagatga   1500

tccccaagtc ttagctgttg ctgctcacga tgttggagaa tatgtgcggc attatccacg   1560

aggcaaacgg gtcatcgagc agctcggtgg gaagcagctg gtcatgaacc acatgcatca   1620

tgaagaccag caggtccgct ataatgctct gctggccgtg cagaagctca tggtgcacaa   1680

ctgggaatac cttggcaagc agctccagtc cgagcagccc cagaccgctg ccgcccgaag   1740

ctaagcctgc ctctggcctt cccctccgcc tcaatgcaga accagtagtg ggagcactgt   1800

gtttagagtt aagagtgaac actgtttgat tttacttgga atttcctctg ttatatagct   1860

tttcccaatg ctaatttcca aacaacaaca acaaaataac atgtttgcct gttaagttgt   1920

ataaaagtag gtgattctgt atttaaagaa aatattactg ttacatatac tgcttgcaat   1980

ttctgtattt attgttctct ggaaataaat atagttatta aaggattctc actccaaaca   2040

tggcctctct ctttacttgg actttgaaca aaagtcaact gttgtctctt ttcaaaccaa   2100

attgggagaa ttgttgcaaa gtagtgaatg gcaaataaat gttttaaaat ctaaaaaaaa   2160

aaaaa                                                               2165


<210>  2262
<211>  483
<212>  PRT
<213>  Homosapiens

<400>  2262

Met Thr Lys Met Asp Ile Arg Gly Ala Val Asp Ala Ala Val Pro Thr 
1               5                   10                  15      


Asn Ile Ile Ala Ala Lys Ala Ala Glu Val Arg Ala Asn Lys Val Asn 
            20                  25                  30          


Trp Gln Ser Tyr Leu Gln Gly Gln Met Ile Ser Ala Glu Asp Cys Glu 
        35                  40                  45              


Phe Ile Gln Arg Phe Glu Met Lys Arg Ser Pro Glu Glu Lys Gln Glu 
    50                  55                  60                  


Met Leu Gln Thr Glu Gly Ser Gln Cys Ala Lys Thr Phe Ile Asn Leu 
65                  70                  75                  80  


Met Thr His Ile Cys Lys Glu Gln Thr Val Gln Tyr Ile Leu Thr Met 
                85                  90                  95      


Val Asp Asp Met Leu Gln Glu Asn His Gln Arg Val Ser Ile Phe Phe 
            100                 105                 110         


Asp Tyr Ala Arg Cys Ser Lys Asn Thr Ala Trp Pro Tyr Phe Leu Pro 
        115                 120                 125             


Met Leu Asn Arg Gln Asp Pro Phe Thr Val His Met Ala Ala Arg Ile 
    130                 135                 140                 


Ile Ala Lys Leu Ala Ala Trp Gly Lys Glu Leu Met Glu Gly Ser Asp 
145                 150                 155                 160 


Leu Asn Tyr Tyr Phe Asn Trp Ile Lys Thr Gln Leu Ser Ser Gln Lys 
                165                 170                 175     


Leu Arg Gly Ser Gly Val Ala Val Glu Thr Gly Thr Val Ser Ser Ser 
            180                 185                 190         


Asp Ser Ser Gln Tyr Val Gln Cys Val Ala Gly Cys Leu Gln Leu Met 
        195                 200                 205             


Leu Arg Val Asn Glu Tyr Arg Phe Ala Trp Val Glu Ala Asp Gly Val 
    210                 215                 220                 


Asn Cys Ile Met Gly Val Leu Ser Asn Lys Cys Gly Phe Gln Leu Gln 
225                 230                 235                 240 


Tyr Gln Met Ile Phe Ser Ile Trp Leu Leu Ala Phe Ser Pro Gln Met 
                245                 250                 255     


Cys Glu His Leu Arg Arg Tyr Asn Ile Ile Pro Val Leu Ser Asp Ile 
            260                 265                 270         


Leu Gln Glu Ser Val Lys Glu Lys Val Thr Arg Ile Ile Leu Ala Ala 
        275                 280                 285             


Phe Arg Asn Phe Leu Glu Lys Ser Thr Glu Arg Glu Thr Arg Gln Glu 
    290                 295                 300                 


Tyr Ala Leu Ala Met Ile Gln Cys Lys Val Leu Lys Gln Leu Glu Asn 
305                 310                 315                 320 


Leu Glu Gln Gln Lys Tyr Asp Asp Glu Asp Ile Ser Glu Asp Ile Lys 
                325                 330                 335     


Phe Leu Leu Glu Lys Leu Gly Glu Ser Val Gln Asp Leu Ser Ser Phe 
            340                 345                 350         


Asp Glu Tyr Ser Ser Glu Leu Lys Ser Gly Arg Leu Glu Trp Ser Pro 
        355                 360                 365             


Val His Lys Ser Glu Lys Phe Trp Arg Glu Asn Ala Val Arg Leu Asn 
    370                 375                 380                 


Glu Lys Asn Tyr Glu Leu Leu Lys Ile Leu Thr Lys Leu Leu Glu Val 
385                 390                 395                 400 


Ser Asp Asp Pro Gln Val Leu Ala Val Ala Ala His Asp Val Gly Glu 
                405                 410                 415     


Tyr Val Arg His Tyr Pro Arg Gly Lys Arg Val Ile Glu Gln Leu Gly 
            420                 425                 430         


Gly Lys Gln Leu Val Met Asn His Met His His Glu Asp Gln Gln Val 
        435                 440                 445             


Arg Tyr Asn Ala Leu Leu Ala Val Gln Lys Leu Met Val His Asn Trp 
    450                 455                 460                 


Glu Tyr Leu Gly Lys Gln Leu Gln Ser Glu Gln Pro Gln Thr Ala Ala 
465                 470                 475                 480 


Ala Arg Ser 
            


<210>  2263
<211>  2111
<212>  DNA
<213>  Homosapiens

<400>  2263
acgtgaccgg cgcctctgtc attctactgc ggccgccctg gcttccttct acctgtgcgg     60

ccctcaacgt ctccttggtg cgggacccgc ttcactttcg gctcccggag tctccctcca    120

ctgctcagac ctctggacct gacaggagac gcctacttgg ctctgacgcg gcgccccagc    180

ccggctgtgt ccccggcgcc ccggaccacc ctccctgccg gctttgggtg cgttgtgggg    240

tcccgaggat tcgcgagatt tgttgaaaga cattcaagat tacgaagttt agatgaccaa    300

aatggatatc cgaggtgctg tggatgctgc tgtccccacc aatattattg ctgccaaggc    360

tgcagaagtt cgtgcaaaca aagtcaactg gcaatcctat cttcagggac agatgatttc    420

tgctgaagat tgtgagttta ttcagaggtt tgaaatgaaa cgaagccctg aagagaagca    480

agagatgctt caaactgaag gcagccagtg tgctaaaaca tttataaatc tgatgactca    540

tatctgcaaa gaacagaccg ttcagtatat actaactatg gtggatgata tgctgcagga    600

aaatcatcag cgtgttagca ttttctttga ctatgcaaga tgtagcaaga acactgcgtg    660

gccctacttt ctgccaatgt tgaatcgcca ggatcccttc actgttcata tggcagcaag    720

aattattgcc aagttagcag cttggggaaa agaactgatg gaaggcagtg acttaaatta    780

ctatttcaat tggataaaaa ctcagctgag ttcacagagt tcgcagtatg tgcagtgcgt    840

ggccgggtgt ttgcagctga tgctccgggt caatgagtac cgctttgctt gggtggaagc    900

agatggggta aattgcataa tgggagtgtt gagtaacaag tgtggctttc agctccagta    960

tcaaatgatt ttttcaatat ggctcctggc attcagtcct caaatgtgtg aacacctgcg   1020

gcgctataat atcattccag ttctgtctga tatccttcag gagtctgtca aagagaaagt   1080

aacaagaatc attcttgcag catttcgtaa ctttttagaa aaatcaactg aaagagaaac   1140

tcgccaagaa tatgccctgg ctatgattca gtgcaaagtt ctgaaacagt tggagaactt   1200

ggaacagcag aagtacgatg atgaagatat cagcgaagat atcaaatttc ttttggaaaa   1260

acttggagag agtgtccagg accttagttc atttgatgaa tacagttcag aacttaaatc   1320

tggaaggttg gaatggagtc ctgtgcacaa atctgagaaa ttttggagag agaatgctgt   1380

gaggttaaat gagaagaatt atgaactctt gaaaatcttg acaaaacttt tggaagtgtc   1440

agatgatccc caagtcttag ctgttgctgc tcacgatgtt ggagaatatg tgcggcatta   1500

tccacgaggc aaacgggtca tcgagcagct cggtgggaag cagctggtca tgaaccacat   1560

gcatcatgaa gaccagcagg tccgctataa tgctctgctg gccgtgcaga agctcatggt   1620

gcacaactgg gaataccttg gcaagcagct ccagtccgag cagccccaga ccgctgccgc   1680

ccgaagctaa gcctgcctct ggccttcccc tccgcctcaa tgcagaacca gtagtgggag   1740

cactgtgttt agagttaaga gtgaacactg tttgatttta cttggaattt cctctgttat   1800

atagcttttc ccaatgctaa tttccaaaca acaacaacaa aataacatgt ttgcctgtta   1860

agttgtataa aagtaggtga ttctgtattt aaagaaaata ttactgttac atatactgct   1920

tgcaatttct gtatttattg ttctctggaa ataaatatag ttattaaagg attctcactc   1980

caaacatggc ctctctcttt acttggactt tgaacaaaag tcaactgttg tctcttttca   2040

aaccaaattg ggagaattgt tgcaaagtag tgaatggcaa ataaatgttt taaaatctaa   2100

aaaaaaaaaa a                                                        2111


<210>  2264
<211>  465
<212>  PRT
<213>  Homosapiens

<400>  2264

Met Thr Lys Met Asp Ile Arg Gly Ala Val Asp Ala Ala Val Pro Thr 
1               5                   10                  15      


Asn Ile Ile Ala Ala Lys Ala Ala Glu Val Arg Ala Asn Lys Val Asn 
            20                  25                  30          


Trp Gln Ser Tyr Leu Gln Gly Gln Met Ile Ser Ala Glu Asp Cys Glu 
        35                  40                  45              


Phe Ile Gln Arg Phe Glu Met Lys Arg Ser Pro Glu Glu Lys Gln Glu 
    50                  55                  60                  


Met Leu Gln Thr Glu Gly Ser Gln Cys Ala Lys Thr Phe Ile Asn Leu 
65                  70                  75                  80  


Met Thr His Ile Cys Lys Glu Gln Thr Val Gln Tyr Ile Leu Thr Met 
                85                  90                  95      


Val Asp Asp Met Leu Gln Glu Asn His Gln Arg Val Ser Ile Phe Phe 
            100                 105                 110         


Asp Tyr Ala Arg Cys Ser Lys Asn Thr Ala Trp Pro Tyr Phe Leu Pro 
        115                 120                 125             


Met Leu Asn Arg Gln Asp Pro Phe Thr Val His Met Ala Ala Arg Ile 
    130                 135                 140                 


Ile Ala Lys Leu Ala Ala Trp Gly Lys Glu Leu Met Glu Gly Ser Asp 
145                 150                 155                 160 


Leu Asn Tyr Tyr Phe Asn Trp Ile Lys Thr Gln Leu Ser Ser Gln Ser 
                165                 170                 175     


Ser Gln Tyr Val Gln Cys Val Ala Gly Cys Leu Gln Leu Met Leu Arg 
            180                 185                 190         


Val Asn Glu Tyr Arg Phe Ala Trp Val Glu Ala Asp Gly Val Asn Cys 
        195                 200                 205             


Ile Met Gly Val Leu Ser Asn Lys Cys Gly Phe Gln Leu Gln Tyr Gln 
    210                 215                 220                 


Met Ile Phe Ser Ile Trp Leu Leu Ala Phe Ser Pro Gln Met Cys Glu 
225                 230                 235                 240 


His Leu Arg Arg Tyr Asn Ile Ile Pro Val Leu Ser Asp Ile Leu Gln 
                245                 250                 255     


Glu Ser Val Lys Glu Lys Val Thr Arg Ile Ile Leu Ala Ala Phe Arg 
            260                 265                 270         


Asn Phe Leu Glu Lys Ser Thr Glu Arg Glu Thr Arg Gln Glu Tyr Ala 
        275                 280                 285             


Leu Ala Met Ile Gln Cys Lys Val Leu Lys Gln Leu Glu Asn Leu Glu 
    290                 295                 300                 


Gln Gln Lys Tyr Asp Asp Glu Asp Ile Ser Glu Asp Ile Lys Phe Leu 
305                 310                 315                 320 


Leu Glu Lys Leu Gly Glu Ser Val Gln Asp Leu Ser Ser Phe Asp Glu 
                325                 330                 335     


Tyr Ser Ser Glu Leu Lys Ser Gly Arg Leu Glu Trp Ser Pro Val His 
            340                 345                 350         


Lys Ser Glu Lys Phe Trp Arg Glu Asn Ala Val Arg Leu Asn Glu Lys 
        355                 360                 365             


Asn Tyr Glu Leu Leu Lys Ile Leu Thr Lys Leu Leu Glu Val Ser Asp 
    370                 375                 380                 


Asp Pro Gln Val Leu Ala Val Ala Ala His Asp Val Gly Glu Tyr Val 
385                 390                 395                 400 


Arg His Tyr Pro Arg Gly Lys Arg Val Ile Glu Gln Leu Gly Gly Lys 
                405                 410                 415     


Gln Leu Val Met Asn His Met His His Glu Asp Gln Gln Val Arg Tyr 
            420                 425                 430         


Asn Ala Leu Leu Ala Val Gln Lys Leu Met Val His Asn Trp Glu Tyr 
        435                 440                 445             


Leu Gly Lys Gln Leu Gln Ser Glu Gln Pro Gln Thr Ala Ala Ala Arg 
    450                 455                 460                 


Ser 
465 


<210>  2265
<211>  2025
<212>  DNA
<213>  Homosapiens

<400>  2265
aggcgactct tgcagtttct ccagcttgcc tggtgcgtgc tggtgtctcg ccgcttggtc     60

ctctcctgtt cttcggcccc cggttgccag attgcttttc ttccaggcct caaccagatt    120

tgttgaaaga cattcaagat tacgaagttt agatgaccaa aatggatatc cgaggtgctg    180

tggatgctgc tgtccccacc aatattattg ctgccaaggc tgcagaagtt cgtgcaaaca    240

aagtcaactg gcaatcctat cttcagggac agatgatttc tgctgaagat tgtgagttta    300

ttcagaggtt tgaaatgaaa cgaagccctg aagagaagca agagatgctt caaactgaag    360

gcagccagtg tgctaaaaca tttataaatc tgatgactca tatctgcaaa gaacagaccg    420

ttcagtatat actaactatg gtggatgata tgctgcagga aaatcatcag cgtgttagca    480

ttttctttga ctatgcaaga tgtagcaaga acactgcgtg gccctacttt ctgccaatgt    540

tgaatcgcca ggatcccttc actgttcata tggcagcaag aattattgcc aagttagcag    600

cttggggaaa agaactgatg gaaggcagtg acttaaatta ctatttcaat tggataaaaa    660

ctcagctgag ttcacagaaa ctgcgtggta gcggtgttgc tgttgaaaca ggaacagtct    720

cttcaagtga tagttcgcag tatgtgcagt gcgtggccgg gtgtttgcag ctgatgctcc    780

gggtcaatga gtaccgcttt gcttgggtgg aagcagatgg ggtaaattgc ataatgggag    840

tgttgagtaa caagtgtggc tttcagctcc agtatcaaat gattttttca atatggctcc    900

tggcattcag tcctcaaatg tgtgaacacc tgcggcgcta taatatcatt ccagttctgt    960

ctgatatcct tcaggagtct gtcaaagaga aagtaacaag aatcattctt gcagcatttc   1020

gtaacttttt agaaaaatca actgaaagag aaactcgcca agaatatgcc ctggctatga   1080

ttcagtgcaa agttctgaaa cagttggaga acttggaaca gcagaagtac gatgatgaag   1140

atatcagcga agatatcaaa tttcttttgg aaaaacttgg agagagtgtc caggacctta   1200

gttcatttga tgaatacagt tcagaactta aatctggaag gttggaatgg agtcctgtgc   1260

acaaatctga gaaattttgg agagagaatg ctgtgaggtt aaatgagaag aattatgaac   1320

tcttgaaaat cttgacaaaa cttttggaag tgtcagatga tccccaagtc ttagctgttg   1380

ctgctcacga tgttggagaa tatgtgcggc attatccacg aggcaaacgg gtcatcgagc   1440

agctcggtgg gaagcagctg gtcatgaacc acatgcatca tgaagaccag caggtccgct   1500

ataatgctct gctggccgtg cagaagctca tggtgcacaa ctgggaatac cttggcaagc   1560

agctccagtc cgagcagccc cagaccgctg ccgcccgaag ctaagcctgc ctctggcctt   1620

cccctccgcc tcaatgcaga accagtagtg ggagcactgt gtttagagtt aagagtgaac   1680

actgtttgat tttacttgga atttcctctg ttatatagct tttcccaatg ctaatttcca   1740

aacaacaaca acaaaataac atgtttgcct gttaagttgt ataaaagtag gtgattctgt   1800

atttaaagaa aatattactg ttacatatac tgcttgcaat ttctgtattt attgttctct   1860

ggaaataaat atagttatta aaggattctc actccaaaca tggcctctct ctttacttgg   1920

actttgaaca aaagtcaact gttgtctctt ttcaaaccaa attgggagaa ttgttgcaaa   1980

gtagtgaatg gcaaataaat gttttaaaat ctaaaaaaaa aaaaa                   2025


<210>  2266
<211>  483
<212>  PRT
<213>  Homosapiens

<400>  2266

Met Thr Lys Met Asp Ile Arg Gly Ala Val Asp Ala Ala Val Pro Thr 
1               5                   10                  15      


Asn Ile Ile Ala Ala Lys Ala Ala Glu Val Arg Ala Asn Lys Val Asn 
            20                  25                  30          


Trp Gln Ser Tyr Leu Gln Gly Gln Met Ile Ser Ala Glu Asp Cys Glu 
        35                  40                  45              


Phe Ile Gln Arg Phe Glu Met Lys Arg Ser Pro Glu Glu Lys Gln Glu 
    50                  55                  60                  


Met Leu Gln Thr Glu Gly Ser Gln Cys Ala Lys Thr Phe Ile Asn Leu 
65                  70                  75                  80  


Met Thr His Ile Cys Lys Glu Gln Thr Val Gln Tyr Ile Leu Thr Met 
                85                  90                  95      


Val Asp Asp Met Leu Gln Glu Asn His Gln Arg Val Ser Ile Phe Phe 
            100                 105                 110         


Asp Tyr Ala Arg Cys Ser Lys Asn Thr Ala Trp Pro Tyr Phe Leu Pro 
        115                 120                 125             


Met Leu Asn Arg Gln Asp Pro Phe Thr Val His Met Ala Ala Arg Ile 
    130                 135                 140                 


Ile Ala Lys Leu Ala Ala Trp Gly Lys Glu Leu Met Glu Gly Ser Asp 
145                 150                 155                 160 


Leu Asn Tyr Tyr Phe Asn Trp Ile Lys Thr Gln Leu Ser Ser Gln Lys 
                165                 170                 175     


Leu Arg Gly Ser Gly Val Ala Val Glu Thr Gly Thr Val Ser Ser Ser 
            180                 185                 190         


Asp Ser Ser Gln Tyr Val Gln Cys Val Ala Gly Cys Leu Gln Leu Met 
        195                 200                 205             


Leu Arg Val Asn Glu Tyr Arg Phe Ala Trp Val Glu Ala Asp Gly Val 
    210                 215                 220                 


Asn Cys Ile Met Gly Val Leu Ser Asn Lys Cys Gly Phe Gln Leu Gln 
225                 230                 235                 240 


Tyr Gln Met Ile Phe Ser Ile Trp Leu Leu Ala Phe Ser Pro Gln Met 
                245                 250                 255     


Cys Glu His Leu Arg Arg Tyr Asn Ile Ile Pro Val Leu Ser Asp Ile 
            260                 265                 270         


Leu Gln Glu Ser Val Lys Glu Lys Val Thr Arg Ile Ile Leu Ala Ala 
        275                 280                 285             


Phe Arg Asn Phe Leu Glu Lys Ser Thr Glu Arg Glu Thr Arg Gln Glu 
    290                 295                 300                 


Tyr Ala Leu Ala Met Ile Gln Cys Lys Val Leu Lys Gln Leu Glu Asn 
305                 310                 315                 320 


Leu Glu Gln Gln Lys Tyr Asp Asp Glu Asp Ile Ser Glu Asp Ile Lys 
                325                 330                 335     


Phe Leu Leu Glu Lys Leu Gly Glu Ser Val Gln Asp Leu Ser Ser Phe 
            340                 345                 350         


Asp Glu Tyr Ser Ser Glu Leu Lys Ser Gly Arg Leu Glu Trp Ser Pro 
        355                 360                 365             


Val His Lys Ser Glu Lys Phe Trp Arg Glu Asn Ala Val Arg Leu Asn 
    370                 375                 380                 


Glu Lys Asn Tyr Glu Leu Leu Lys Ile Leu Thr Lys Leu Leu Glu Val 
385                 390                 395                 400 


Ser Asp Asp Pro Gln Val Leu Ala Val Ala Ala His Asp Val Gly Glu 
                405                 410                 415     


Tyr Val Arg His Tyr Pro Arg Gly Lys Arg Val Ile Glu Gln Leu Gly 
            420                 425                 430         


Gly Lys Gln Leu Val Met Asn His Met His His Glu Asp Gln Gln Val 
        435                 440                 445             


Arg Tyr Asn Ala Leu Leu Ala Val Gln Lys Leu Met Val His Asn Trp 
    450                 455                 460                 


Glu Tyr Leu Gly Lys Gln Leu Gln Ser Glu Gln Pro Gln Thr Ala Ala 
465                 470                 475                 480 


Ala Arg Ser 
            


<210>  2267
<211>  1596
<212>  DNA
<213>  Homosapiens

<400>  2267
ccgcgggacg catgcgcacg gcggacggag gcgagccggc cggggcttcc tccccggccg     60

gcagggtgga cggtgggctc cagatgggat cagagcggat ggagatgcgg aagcggcaga    120

tgcccgccgc ccaggacaca ccaggcgccg ccccaggcca gcccggagcg gggagtcgcg    180

ggtccaacgc atgctgcttc tgctggtgct gctgttgtag ctgctcgtgt ctcactgtta    240

gaaaccagga agatcagagg cccacaatag cttcccacga actcagagca gatcttccaa    300

cctgggaaga aagccctgct cctactctgg aagaagtcaa cgcctgggct cagtcatttg    360

acaaattaat ggtcactcca gcaggaagga atgcattccg tgaattcctc cgaacagaat    420

tcagtgagga aaatatgctc ttctggatgg cctgtgagga actgaaaaag gaagctaata    480

aaaacattat tgaagagaaa gcaaggataa tctatgaaga ctacatttct atactttctc    540

ctaaggaggt gagcttagac tcccgggtga gagaagtgat caacagaaac atggtggagc    600

catcccaaca catattcgat gatgctcaac ttcagattta caccctgatg cacagagact    660

catatcctcg attcatgaac tctgctgtct ataaggactt gcttcagtcc ttatcggaga    720

aatctattga agcataggat ttttcaaata tatttattat taataaaata ataaaagaat    780

tcatgggcta caactagcac agggaattta gaggttgtag catcttctgc tggagtaata    840

ctcaggctat tctaataaca gatgattcct tcaacagact gctatatatt caccatgtaa    900

actgcagcca cctttagtga tacttttaaa aaaaaaaata aagggatatg gctgttgtag    960

aaagatagcg tatttgcatt tacaataaca gtagcatgtt gtcagtggcc aaggctacac   1020

agaaggctcc ctgctgcccg gagcaggtac atccacagag caaagggaac cacttttatt   1080

ttgcatgagt ttggtaactg attactctcc cctcaaagaa aagacattca ggtgtttctc   1140

aacgacatct tctgtccagc aagctcggtt tgaatacgtc acttaccagt gccattgcag   1200

gacccaaatt cacagttcat aaaagatgtg accactacat gtaaaaatag cattctactt   1260

gatcttacag tatgtatgta tgtatgtatg gagacatatg tgtgcgtgtg gatgtctaca   1320

tggttaatgg aaagcactgt gctctgaagt ggatcagtct caagtgtctg gtaacagcag   1380

caatgcttag aaaattcttt tgttgaaaag agttactgtt attatcagaa tttgccaacc   1440

taaagaatga atttttaaat tcataacttg gtcatgttca caacaaaact gtcaaataag   1500

catatttcca tttttattac tgaaagaaat atgggcattt tcattcttta aagaaataaa   1560

gcacaagaat tttatctcaa aaaaaaaaaa aaaaaa                             1596


<210>  2268
<211>  241
<212>  PRT
<213>  Homosapiens

<400>  2268

Met Arg Thr Ala Asp Gly Gly Glu Pro Ala Gly Ala Ser Ser Pro Ala 
1               5                   10                  15      


Gly Arg Val Asp Gly Gly Leu Gln Met Gly Ser Glu Arg Met Glu Met 
            20                  25                  30          


Arg Lys Arg Gln Met Pro Ala Ala Gln Asp Thr Pro Gly Ala Ala Pro 
        35                  40                  45              


Gly Gln Pro Gly Ala Gly Ser Arg Gly Ser Asn Ala Cys Cys Phe Cys 
    50                  55                  60                  


Trp Cys Cys Cys Cys Ser Cys Ser Cys Leu Thr Val Arg Asn Gln Glu 
65                  70                  75                  80  


Asp Gln Arg Pro Thr Ile Ala Ser His Glu Leu Arg Ala Asp Leu Pro 
                85                  90                  95      


Thr Trp Glu Glu Ser Pro Ala Pro Thr Leu Glu Glu Val Asn Ala Trp 
            100                 105                 110         


Ala Gln Ser Phe Asp Lys Leu Met Val Thr Pro Ala Gly Arg Asn Ala 
        115                 120                 125             


Phe Arg Glu Phe Leu Arg Thr Glu Phe Ser Glu Glu Asn Met Leu Phe 
    130                 135                 140                 


Trp Met Ala Cys Glu Glu Leu Lys Lys Glu Ala Asn Lys Asn Ile Ile 
145                 150                 155                 160 


Glu Glu Lys Ala Arg Ile Ile Tyr Glu Asp Tyr Ile Ser Ile Leu Ser 
                165                 170                 175     


Pro Lys Glu Val Ser Leu Asp Ser Arg Val Arg Glu Val Ile Asn Arg 
            180                 185                 190         


Asn Met Val Glu Pro Ser Gln His Ile Phe Asp Asp Ala Gln Leu Gln 
        195                 200                 205             


Ile Tyr Thr Leu Met His Arg Asp Ser Tyr Pro Arg Phe Met Asn Ser 
    210                 215                 220                 


Ala Val Tyr Lys Asp Leu Leu Gln Ser Leu Ser Glu Lys Ser Ile Glu 
225                 230                 235                 240 


Ala 
    


<210>  2269
<211>  2102
<212>  DNA
<213>  Homosapiens

<400>  2269
cattaaccaa acaaagagaa gcagagtgga tcctgtgcta atattgggaa aaccaggcaa     60

caggactcat ttggggcctt tattgtgaaa acatgcccca gctttcccaa gataaccaag    120

agtgcctcca gaaacatttc tccaggccgt ctatatggac acagtttctg cccctgttca    180

gggctcagag atataataca gacattcacc aaatcacaga aaatgaagga gacctcaggg    240

ctgttcctga tatcaagtcc ttcccgcctg cacagctccc agactcgccc gccgccccga    300

agctgttcgg cctcctttct agcccgcttt ccagcctcgc aaggttcttc tctcaccttc    360

tccggcgacc ccctcccgag gctccccgga ggcgcctgga cttctccccc ctgcttcccg    420

ccctgccggc cgcccggctc tcgagggggc acgaggagct gccgggccgc ctctcgctcc    480

tgctcggggc ggcgctggca ctgcccggcc gaccctcggg gggtcgtccg ctgaggcccc    540

cccatccggt agccaagccc agggaagaag acgccaccgc tgggcagagc tcgcctatgc    600

cgcagatggg atcagagcgg atggagatgc ggaagcggca gatgcccgcc gcccaggaca    660

caccaggcgc cgccccaggc cagcccggag cggggagtcg cgggtccaac gcatgctgct    720

tctgctggtg ctgctgttgt agctgctcgt gtctcactgt tagaaaccag gaagatcaga    780

ggcccacaat agcttcccac gaactcagag cagatcttcc aacctgggaa gaaagccctg    840

ctcctactct ggaagaagtc aacgcctggg ctcagtcatt tgacaaatta atggtcactc    900

cagcaggaag gaatgcattc cgtgaattcc tccgaacaga attcagtgag gaaaatatgc    960

tcttctggat ggcctgtgag gaactgaaaa aggaagctaa taaaaacatt attgaagaga   1020

aagcaaggat aatctatgaa gactacattt ctatactttc tcctaaggag gtgagcttag   1080

actcccgggt gagagaagtg atcaacagaa acatggtgga gccatcccaa cacatattcg   1140

atgatgctca acttcagatt tacaccctga tgcacagaga ctcatatcct cgattcatga   1200

actctgctgt ctataaggac ttgcttcagt ccttatcgga gaaatctatt gaagcatagg   1260

atttttcaaa tatatttatt attaataaaa taataaaaga attcatgggc tacaactagc   1320

acagggaatt tagaggttgt agcatcttct gctggagtaa tactcaggct attctaataa   1380

cagatgattc cttcaacaga ctgctatata ttcaccatgt aaactgcagc cacctttagt   1440

gatactttta aaaaaaaaaa taaagggata tggctgttgt agaaagatag cgtatttgca   1500

tttacaataa cagtagcatg ttgtcagtgg ccaaggctac acagaaggct ccctgctgcc   1560

cggagcaggt acatccacag agcaaaggga accactttta ttttgcatga gtttggtaac   1620

tgattactct cccctcaaag aaaagacatt caggtgtttc tcaacgacat cttctgtcca   1680

gcaagctcgg tttgaatacg tcacttacca gtgccattgc aggacccaaa ttcacagttc   1740

ataaaagatg tgaccactac atgtaaaaat agcattctac ttgatcttac agtatgtatg   1800

tatgtatgta tggagacata tgtgtgcgtg tggatgtcta catggttaat ggaaagcact   1860

gtgctctgaa gtggatcagt ctcaagtgtc tggtaacagc agcaatgctt agaaaattct   1920

tttgttgaaa agagttactg ttattatcag aatttgccaa cctaaagaat gaatttttaa   1980

attcataact tggtcatgtt cacaacaaaa ctgtcaaata agcatatttc catttttatt   2040

actgaaagaa atatgggcat tttcattctt taaagaaata aagcacaaga attttatctc   2100

aa                                                                  2102


<210>  2270
<211>  388
<212>  PRT
<213>  Homosapiens

<400>  2270

Met Pro Gln Leu Ser Gln Asp Asn Gln Glu Cys Leu Gln Lys His Phe 
1               5                   10                  15      


Ser Arg Pro Ser Ile Trp Thr Gln Phe Leu Pro Leu Phe Arg Ala Gln 
            20                  25                  30          


Arg Tyr Asn Thr Asp Ile His Gln Ile Thr Glu Asn Glu Gly Asp Leu 
        35                  40                  45              


Arg Ala Val Pro Asp Ile Lys Ser Phe Pro Pro Ala Gln Leu Pro Asp 
    50                  55                  60                  


Ser Pro Ala Ala Pro Lys Leu Phe Gly Leu Leu Ser Ser Pro Leu Ser 
65                  70                  75                  80  


Ser Leu Ala Arg Phe Phe Ser His Leu Leu Arg Arg Pro Pro Pro Glu 
                85                  90                  95      


Ala Pro Arg Arg Arg Leu Asp Phe Ser Pro Leu Leu Pro Ala Leu Pro 
            100                 105                 110         


Ala Ala Arg Leu Ser Arg Gly His Glu Glu Leu Pro Gly Arg Leu Ser 
        115                 120                 125             


Leu Leu Leu Gly Ala Ala Leu Ala Leu Pro Gly Arg Pro Ser Gly Gly 
    130                 135                 140                 


Arg Pro Leu Arg Pro Pro His Pro Val Ala Lys Pro Arg Glu Glu Asp 
145                 150                 155                 160 


Ala Thr Ala Gly Gln Ser Ser Pro Met Pro Gln Met Gly Ser Glu Arg 
                165                 170                 175     


Met Glu Met Arg Lys Arg Gln Met Pro Ala Ala Gln Asp Thr Pro Gly 
            180                 185                 190         


Ala Ala Pro Gly Gln Pro Gly Ala Gly Ser Arg Gly Ser Asn Ala Cys 
        195                 200                 205             


Cys Phe Cys Trp Cys Cys Cys Cys Ser Cys Ser Cys Leu Thr Val Arg 
    210                 215                 220                 


Asn Gln Glu Asp Gln Arg Pro Thr Ile Ala Ser His Glu Leu Arg Ala 
225                 230                 235                 240 


Asp Leu Pro Thr Trp Glu Glu Ser Pro Ala Pro Thr Leu Glu Glu Val 
                245                 250                 255     


Asn Ala Trp Ala Gln Ser Phe Asp Lys Leu Met Val Thr Pro Ala Gly 
            260                 265                 270         


Arg Asn Ala Phe Arg Glu Phe Leu Arg Thr Glu Phe Ser Glu Glu Asn 
        275                 280                 285             


Met Leu Phe Trp Met Ala Cys Glu Glu Leu Lys Lys Glu Ala Asn Lys 
    290                 295                 300                 


Asn Ile Ile Glu Glu Lys Ala Arg Ile Ile Tyr Glu Asp Tyr Ile Ser 
305                 310                 315                 320 


Ile Leu Ser Pro Lys Glu Val Ser Leu Asp Ser Arg Val Arg Glu Val 
                325                 330                 335     


Ile Asn Arg Asn Met Val Glu Pro Ser Gln His Ile Phe Asp Asp Ala 
            340                 345                 350         


Gln Leu Gln Ile Tyr Thr Leu Met His Arg Asp Ser Tyr Pro Arg Phe 
        355                 360                 365             


Met Asn Ser Ala Val Tyr Lys Asp Leu Leu Gln Ser Leu Ser Glu Lys 
    370                 375                 380                 


Ser Ile Glu Ala 
385             


<210>  2271
<211>  2784
<212>  DNA
<213>  Homosapiens

<400>  2271
agccggaagc cacgcctgcc cactagcccg acgcccgcct ggcgggaaca tgggctcgcc     60

cctcaccagc gatctgcagt cagttggtag cgcctgcacg tcgcgcgcgg tgttcgattg    120

tcgctgcctg gggaggagga gccggagccg ccgccgccgc cgccgccgcc gcgggcttcg    180

ttcgtaagga agggggccta ggcccgggcc tgcggtggtg ggggttgctg cgcgccgggg    240

gtcgctcctg ctgtgtcttc cgctccagct tcgcccactt ccccttgcca gcggggtggg    300

cgcggagaag acctgccgga gccatggagg acgaagtggt ccgctttgcc aagaagatgg    360

acaagatggt gcagaagaag aacgcggctg gagcattgga tttgctaaag gagcttaaga    420

atattcctat gaccctggaa ttactgcagt ccacaagaat cggaatgtca gttaatgcta    480

ttcgcaagca gagtacagat gaggaagtta catctttggc aaagtctctc atcaaatcct    540

ggaaaaaatt attagatggg ccatcaactg agaaagacct tgacgaaaag aagaaagaac    600

ctgcaattac atcgcagaac agccctgagg caagagaaga aagtacttcc agcggcaatg    660

taagcaacag aaaggatgag acaaatgctc gagatactta tgtttcatcc tttcctcggg    720

caccaagcac ttctgattct gtgcggttga agtgtaggga gatgcttgct gcagctcttc    780

gaacagggga tgactacatt gcaattggag ctgatgagga agaattagga tctcaaattg    840

aagaagctat atatcaagaa ataaggaata cagacatgaa atacaaaaat agagtacgaa    900

gtaggatatc aaatcttaaa gatgcaaaaa atccaaattt aaggaaaaat gtcctctgtg    960

ggaatattcc tcctgactta tttgctagaa tgacagcaga ggaaatggct agtgatgagc   1020

tgaaagagat gcggaaaaac ttgaccaaag aagccatcag agagcatcag atggccaaga   1080

ctggtgggac ccagactgac ttgttcacat gtggcaaatg taaaaagaag aattgcactt   1140

acacacaggt acaaacccgt agtgctgatg aaccaatgac aacatttgtt gtctgtaatg   1200

aatgtggaaa tcgatggaag ttctgttgag ttggaagaat tggcaaaata tctggaccat   1260

taagaaaacg gattttgtaa ctagctttaa actaggccaa gcaactagtt ttcctgcaaa   1320

tcaaattttt aaagcaactt gggttagact ttgtttttga cctaacatcc cttccttaaa   1380

tgccttctgt agtttcagat cagtagggag accatataat aattttatgg tacctgtttc   1440

aaaacatatt ttttctgttt ttataagtaa gttgatatta attaaactct tggcaatatt   1500

tcttctttct taaaggaaaa tataccttaa ctttttttct tttacactgt gaaacataca   1560

cagtagaaat tctgttactc tctgttatta atacataaat gaaaatacat ttttttccat   1620

attggcatgt agctacaaat attaaaggag gagaaaaggt aatataattt taggtttacc   1680

aaatatggtg tgtattcaaa taatacttga ccagcttatc taaaatgtac ataattttga   1740

ggtagcttat gaatttgatt ttaattatta tgttcacaag cttggaatat tagatattat   1800

tttgcatctg taactaaccg tgatcatcat ttcttgtaat ttcttgtaca tgtatattac   1860

ttgttcttaa tagatttttg gaaacaagac tttattgaga tcagtttggt tttcctgtta   1920

atttacctgt ttgactttat aatgtgtttt agttttgcag aagaacactg ttgtagttta   1980

gaaggctttt cataaatccc ctcataggca aagatgaaaa cttcccacta tttttttccc   2040

ctcttaggaa gacatactgg aaagaaaatg tttagcatct tagtgtagta tagctattgt   2100

aaacagttca tgactagatt ttgattcgga aatctatact gaccaaggat taatcttaag   2160

gattgtataa ttcattaaag ctgtggtctt tccatgtgga gactgataga aaataatttt   2220

gtcccaagtc ttatttgctg actttttctg tcatgagtga gattgttgaa caaactgaat   2280

atatgggcta tagcaagtag ctttacagta cagatcttac aattaagttt tgcttttgtt   2340

aaagtgtgta ccattttttc tgtttggagt aagacaaaaa ttgttttgac ataggttccc   2400

tagggtacac ttgctctagc atactttaaa ggccactgtt gcaaagtcta cattttatgc   2460

tgaatctgca ttctgtcagg cacccgtaga aagacctcag tacatgcttt gcactctcct   2520

ttgctccctt tttccaattt cttattgcat atcattttgt tgtaatacag aaagcagcat   2580

ttttaaatgt ccgtgttaag aattggccca ctggtaccaa ctcacctcta ttttgtcagt   2640

tcatagttga agattttgtt ttatttcaaa aacaaagtac atttttgaaa taatgtttca   2700

gaataaaata atctcacttt taagtgatcc attttaaaat ttgtaattca ataaagtttt   2760

ttttgttgtt aaacataaaa aaaa                                          2784


<210>  2272
<211>  301
<212>  PRT
<213>  Homosapiens

<400>  2272

Met Glu Asp Glu Val Val Arg Phe Ala Lys Lys Met Asp Lys Met Val 
1               5                   10                  15      


Gln Lys Lys Asn Ala Ala Gly Ala Leu Asp Leu Leu Lys Glu Leu Lys 
            20                  25                  30          


Asn Ile Pro Met Thr Leu Glu Leu Leu Gln Ser Thr Arg Ile Gly Met 
        35                  40                  45              


Ser Val Asn Ala Ile Arg Lys Gln Ser Thr Asp Glu Glu Val Thr Ser 
    50                  55                  60                  


Leu Ala Lys Ser Leu Ile Lys Ser Trp Lys Lys Leu Leu Asp Gly Pro 
65                  70                  75                  80  


Ser Thr Glu Lys Asp Leu Asp Glu Lys Lys Lys Glu Pro Ala Ile Thr 
                85                  90                  95      


Ser Gln Asn Ser Pro Glu Ala Arg Glu Glu Ser Thr Ser Ser Gly Asn 
            100                 105                 110         


Val Ser Asn Arg Lys Asp Glu Thr Asn Ala Arg Asp Thr Tyr Val Ser 
        115                 120                 125             


Ser Phe Pro Arg Ala Pro Ser Thr Ser Asp Ser Val Arg Leu Lys Cys 
    130                 135                 140                 


Arg Glu Met Leu Ala Ala Ala Leu Arg Thr Gly Asp Asp Tyr Ile Ala 
145                 150                 155                 160 


Ile Gly Ala Asp Glu Glu Glu Leu Gly Ser Gln Ile Glu Glu Ala Ile 
                165                 170                 175     


Tyr Gln Glu Ile Arg Asn Thr Asp Met Lys Tyr Lys Asn Arg Val Arg 
            180                 185                 190         


Ser Arg Ile Ser Asn Leu Lys Asp Ala Lys Asn Pro Asn Leu Arg Lys 
        195                 200                 205             


Asn Val Leu Cys Gly Asn Ile Pro Pro Asp Leu Phe Ala Arg Met Thr 
    210                 215                 220                 


Ala Glu Glu Met Ala Ser Asp Glu Leu Lys Glu Met Arg Lys Asn Leu 
225                 230                 235                 240 


Thr Lys Glu Ala Ile Arg Glu His Gln Met Ala Lys Thr Gly Gly Thr 
                245                 250                 255     


Gln Thr Asp Leu Phe Thr Cys Gly Lys Cys Lys Lys Lys Asn Cys Thr 
            260                 265                 270         


Tyr Thr Gln Val Gln Thr Arg Ser Ala Asp Glu Pro Met Thr Thr Phe 
        275                 280                 285             


Val Val Cys Asn Glu Cys Gly Asn Arg Trp Lys Phe Cys 
    290                 295                 300     


<210>  2273
<211>  2721
<212>  DNA
<213>  Homosapiens

<400>  2273
agccggaagc cacgcctgcc cactagcccg acgcccgcct ggcgggaaca tgggctcgcc     60

cctcaccagc gatctgcagt cagttggtag cgcctgcacg tcgcgcgcgg tgttcgattg    120

tcgctgcctg gggaggagga gccggagccg ccgccgccgc cgccgccgcc gcgggcttcg    180

ttcgtaagga agggggccta ggcccgggcc tgcggtggtg ggggttgctg cgcgccgggg    240

gtcgctcctg ctgtgtcttc cgctccagct tcgcccactt ccccttgcca gcggggtggg    300

cgcggagaag acctgccgga gccatggagg acgaagtggt ccgctttgcc aagaagatgg    360

acaagatggt gcagaagaag aacgcgtcca caagaatcgg aatgtcagtt aatgctattc    420

gcaagcagag tacagatgag gaagttacat ctttggcaaa gtctctcatc aaatcctgga    480

aaaaattatt agatgggcca tcaactgaga aagaccttga cgaaaagaag aaagaacctg    540

caattacatc gcagaacagc cctgaggcaa gagaagaaag tacttccagc ggcaatgtaa    600

gcaacagaaa ggatgagaca aatgctcgag atacttatgt ttcatccttt cctcgggcac    660

caagcacttc tgattctgtg cggttgaagt gtagggagat gcttgctgca gctcttcgaa    720

caggggatga ctacattgca attggagctg atgaggaaga attaggatct caaattgaag    780

aagctatata tcaagaaata aggaatacag acatgaaata caaaaataga gtacgaagta    840

ggatatcaaa tcttaaagat gcaaaaaatc caaatttaag gaaaaatgtc ctctgtggga    900

atattcctcc tgacttattt gctagaatga cagcagagga aatggctagt gatgagctga    960

aagagatgcg gaaaaacttg accaaagaag ccatcagaga gcatcagatg gccaagactg   1020

gtgggaccca gactgacttg ttcacatgtg gcaaatgtaa aaagaagaat tgcacttaca   1080

cacaggtaca aacccgtagt gctgatgaac caatgacaac atttgttgtc tgtaatgaat   1140

gtggaaatcg atggaagttc tgttgagttg gaagaattgg caaaatatct ggaccattaa   1200

gaaaacggat tttgtaacta gctttaaact aggccaagca actagttttc ctgcaaatca   1260

aatttttaaa gcaacttggg ttagactttg tttttgacct aacatccctt ccttaaatgc   1320

cttctgtagt ttcagatcag tagggagacc atataataat tttatggtac ctgtttcaaa   1380

acatattttt tctgttttta taagtaagtt gatattaatt aaactcttgg caatatttct   1440

tctttcttaa aggaaaatat accttaactt tttttctttt acactgtgaa acatacacag   1500

tagaaattct gttactctct gttattaata cataaatgaa aatacatttt tttccatatt   1560

ggcatgtagc tacaaatatt aaaggaggag aaaaggtaat ataattttag gtttaccaaa   1620

tatggtgtgt attcaaataa tacttgacca gcttatctaa aatgtacata attttgaggt   1680

agcttatgaa tttgatttta attattatgt tcacaagctt ggaatattag atattatttt   1740

gcatctgtaa ctaaccgtga tcatcatttc ttgtaatttc ttgtacatgt atattacttg   1800

ttcttaatag atttttggaa acaagacttt attgagatca gtttggtttt cctgttaatt   1860

tacctgtttg actttataat gtgttttagt tttgcagaag aacactgttg tagtttagaa   1920

ggcttttcat aaatcccctc ataggcaaag atgaaaactt cccactattt ttttcccctc   1980

ttaggaagac atactggaaa gaaaatgttt agcatcttag tgtagtatag ctattgtaaa   2040

cagttcatga ctagattttg attcggaaat ctatactgac caaggattaa tcttaaggat   2100

tgtataattc attaaagctg tggtctttcc atgtggagac tgatagaaaa taattttgtc   2160

ccaagtctta tttgctgact ttttctgtca tgagtgagat tgttgaacaa actgaatata   2220

tgggctatag caagtagctt tacagtacag atcttacaat taagttttgc ttttgttaaa   2280

gtgtgtacca ttttttctgt ttggagtaag acaaaaattg ttttgacata ggttccctag   2340

ggtacacttg ctctagcata ctttaaaggc cactgttgca aagtctacat tttatgctga   2400

atctgcattc tgtcaggcac ccgtagaaag acctcagtac atgctttgca ctctcctttg   2460

ctcccttttt ccaatttctt attgcatatc attttgttgt aatacagaaa gcagcatttt   2520

taaatgtccg tgttaagaat tggcccactg gtaccaactc acctctattt tgtcagttca   2580

tagttgaaga ttttgtttta tttcaaaaac aaagtacatt tttgaaataa tgtttcagaa   2640

taaaataatc tcacttttaa gtgatccatt ttaaaatttg taattcaata aagttttttt   2700

tgttgttaaa cataaaaaaa a                                             2721


<210>  2274
<211>  280
<212>  PRT
<213>  Homosapiens

<400>  2274

Met Glu Asp Glu Val Val Arg Phe Ala Lys Lys Met Asp Lys Met Val 
1               5                   10                  15      


Gln Lys Lys Asn Ala Ser Thr Arg Ile Gly Met Ser Val Asn Ala Ile 
            20                  25                  30          


Arg Lys Gln Ser Thr Asp Glu Glu Val Thr Ser Leu Ala Lys Ser Leu 
        35                  40                  45              


Ile Lys Ser Trp Lys Lys Leu Leu Asp Gly Pro Ser Thr Glu Lys Asp 
    50                  55                  60                  


Leu Asp Glu Lys Lys Lys Glu Pro Ala Ile Thr Ser Gln Asn Ser Pro 
65                  70                  75                  80  


Glu Ala Arg Glu Glu Ser Thr Ser Ser Gly Asn Val Ser Asn Arg Lys 
                85                  90                  95      


Asp Glu Thr Asn Ala Arg Asp Thr Tyr Val Ser Ser Phe Pro Arg Ala 
            100                 105                 110         


Pro Ser Thr Ser Asp Ser Val Arg Leu Lys Cys Arg Glu Met Leu Ala 
        115                 120                 125             


Ala Ala Leu Arg Thr Gly Asp Asp Tyr Ile Ala Ile Gly Ala Asp Glu 
    130                 135                 140                 


Glu Glu Leu Gly Ser Gln Ile Glu Glu Ala Ile Tyr Gln Glu Ile Arg 
145                 150                 155                 160 


Asn Thr Asp Met Lys Tyr Lys Asn Arg Val Arg Ser Arg Ile Ser Asn 
                165                 170                 175     


Leu Lys Asp Ala Lys Asn Pro Asn Leu Arg Lys Asn Val Leu Cys Gly 
            180                 185                 190         


Asn Ile Pro Pro Asp Leu Phe Ala Arg Met Thr Ala Glu Glu Met Ala 
        195                 200                 205             


Ser Asp Glu Leu Lys Glu Met Arg Lys Asn Leu Thr Lys Glu Ala Ile 
    210                 215                 220                 


Arg Glu His Gln Met Ala Lys Thr Gly Gly Thr Gln Thr Asp Leu Phe 
225                 230                 235                 240 


Thr Cys Gly Lys Cys Lys Lys Lys Asn Cys Thr Tyr Thr Gln Val Gln 
                245                 250                 255     


Thr Arg Ser Ala Asp Glu Pro Met Thr Thr Phe Val Val Cys Asn Glu 
            260                 265                 270         


Cys Gly Asn Arg Trp Lys Phe Cys 
        275                 280 


<210>  2275
<211>  2578
<212>  DNA
<213>  Homosapiens

<400>  2275
cggcgggcga ggggcagggc agggcggacc ctggacgcgc gggcgcgcgc ggaaggtagc     60

gcggggccgc gttggcgcgc acgcgcctga gcgtgcgccc ggtggggccg gccgggactc    120

gccgctcgca cgcccttggg ccgcggccgg gcgcccgctc ttccttccgc ttgcgctgtg    180

agctgaggcg gtgtatgtgc ggcaataaca tgtcaacccc gctgcccgcc atcgtgcccg    240

ccgcccggaa ggccaccgct gcggtgattt tcctgcatgg attgggagat actgggcacg    300

gatgggcaga agcctttgca ggtatcagaa gttcacatat caaatatatc tgcccgcatg    360

cgcctgttag gcctgttaca ttaaatatga acgtggctat gccttcatgg tttgatatta    420

ttgggctttc accagattca caggaggatg aatctgggat taaacaggca gcagaaaata    480

taaaagcttt gattgatcaa gaagtgaaga atggcattcc ttctaacaga attattttgg    540

gagggttttc tcagggagga gctttatctt tatatactgc ccttaccaca cagcagaaac    600

tggcaggtgt cactgcactc agttgctggc ttccacttcg ggcttccttt ccacagggtc    660

ctatcggtgg tgctaataga gatatttcta ttctccagtg ccacggggat tgtgaccctt    720

tggttcccct gatgtttggt tctcttacgg tggaaaaact aaaaacattg gtgaatccag    780

ccaatgtgac ctttaaaacc tatgaaggta tgatgcacag ttcgtgtcaa caggaaatga    840

tggatgtcaa gcaattcatt gataaactcc tacctccaat tgattgacgt cactaagagg    900

ccttgtgtag aagtacacca gcatcattgt agtagagtgt aaaccttttc ccatgcccag    960

tcttcaaatt tctaatgttt tgcagtgtta aaatgttttg caaatacatg ccaataacac   1020

agatcaaata atatctcctc atgagaaatt tatgatcttt taagtttcta tacatgtatt   1080

cttataagac gacccaggat ctactatatt agaatagatg aagcaggtag cttctttttt   1140

ctcaaatgta attcagcaaa ataatacagt actgccacca gattttttat tacatcattt   1200

gaaaattagc agtatgctta atgaaaattt gttcaggtat aaatgagcag ttaagatata   1260

aacaatttat gcatgctgtg acttagtcta tggatttatt ccaaaattgc ttagtcacca   1320

tgcagtgtct gtatttttat atatgtgttc atatatacat aatgattata atacataata   1380

agaatgaggt ggtattacat tattcctaat aatagggata atgctgttta ttgtcaagaa   1440

aaagtaaaat cgttctcttc aattaatggc ccttttattt tgggaccagg cttttatttt   1500

ccctgatatt atttctattt aatactcttt tctctcaaga aaaaaaaaaa agtttgtttt   1560

ttctttattg tccttcatag caggccaagt attgcctctc tgcaatagac agctactgtc   1620

aatacatgct gtaatttgac attctgggtc acagatataa ggtatttaaa atctatttat   1680

gctttataga gaaaccagac attaaaactt catgcactac ttatttcgaa ttactgtacc   1740

ttatccaaat ttacacctag ctattaggat cttcaaccca ggtaacagga ataattctgt   1800

ggtttcattt ttctgtaaac aactgaaaga ataattagat catattctag tatgttctga   1860

aatatcttta agactgatct taaaaactaa cttctaagat gatttcatct tctcatagta   1920

tagagtttac tttgtacacg tttgaaacca actactgtag aagatgagga atctattgta   1980

attttttgct ttattttcat ctgccagtgg acttatttga aattttcact ttagtcaaat   2040

tattttttgt attagttttt gatgcagaca taaaaatagc aatcatttta aattgtcaaa   2100

atttccagat tactggtaaa aattatttga aaacaaactt atgggtaata aaggctagtc   2160

agaaccctat accataaagt gtagttacca tacagattaa tatgtagcaa aaatgtatgc   2220

ttgatatttc tcaactgtgt taatttttct gctgtattcc agctgaccaa aacaatatta   2280

agaatgcatc tttataaatg ggtgctaatt gataatggaa ataatttagt aatggactat   2340

acaggatgtt aataatgaag ccatatgttt atgtctggat ttaaaaattt taaacaatca   2400

tttactatgt catttttctt taccttgaag aacataaact gttatttcac ttctacaaat   2460

cagcaagata ttatttatgg caagaaatat tccattgaaa tattgtgctg taacatggga   2520

aagtgtaaat gtttttcatg gtttctatca atgtgaaata aaatttaatt ctgaaaaa     2578


<210>  2276
<211>  230
<212>  PRT
<213>  Homosapiens

<400>  2276

Met Cys Gly Asn Asn Met Ser Thr Pro Leu Pro Ala Ile Val Pro Ala 
1               5                   10                  15      


Ala Arg Lys Ala Thr Ala Ala Val Ile Phe Leu His Gly Leu Gly Asp 
            20                  25                  30          


Thr Gly His Gly Trp Ala Glu Ala Phe Ala Gly Ile Arg Ser Ser His 
        35                  40                  45              


Ile Lys Tyr Ile Cys Pro His Ala Pro Val Arg Pro Val Thr Leu Asn 
    50                  55                  60                  


Met Asn Val Ala Met Pro Ser Trp Phe Asp Ile Ile Gly Leu Ser Pro 
65                  70                  75                  80  


Asp Ser Gln Glu Asp Glu Ser Gly Ile Lys Gln Ala Ala Glu Asn Ile 
                85                  90                  95      


Lys Ala Leu Ile Asp Gln Glu Val Lys Asn Gly Ile Pro Ser Asn Arg 
            100                 105                 110         


Ile Ile Leu Gly Gly Phe Ser Gln Gly Gly Ala Leu Ser Leu Tyr Thr 
        115                 120                 125             


Ala Leu Thr Thr Gln Gln Lys Leu Ala Gly Val Thr Ala Leu Ser Cys 
    130                 135                 140                 


Trp Leu Pro Leu Arg Ala Ser Phe Pro Gln Gly Pro Ile Gly Gly Ala 
145                 150                 155                 160 


Asn Arg Asp Ile Ser Ile Leu Gln Cys His Gly Asp Cys Asp Pro Leu 
                165                 170                 175     


Val Pro Leu Met Phe Gly Ser Leu Thr Val Glu Lys Leu Lys Thr Leu 
            180                 185                 190         


Val Asn Pro Ala Asn Val Thr Phe Lys Thr Tyr Glu Gly Met Met His 
        195                 200                 205             


Ser Ser Cys Gln Gln Glu Met Met Asp Val Lys Gln Phe Ile Asp Lys 
    210                 215                 220                 


Leu Leu Pro Pro Ile Asp 
225                 230 


<210>  2277
<211>  1155
<212>  DNA
<213>  Homosapiens

<400>  2277
cccgagacca cgtggcctcc gagcagctca gggcgccctt gaaagttctt ggatctgcgg     60

gttatggccg gtcccttgca gggcggtggg gcccgggccc tggacctact ccggggcctg    120

ccgcgtgtga gcctggccaa cttaaagccg aatcccggct ccaagaaacc ggagagaaga    180

ccaagaggtc ggagaagagg tagaaaatgt ggcagaggcc ataaaggaga aaggcaaaga    240

ggaacccggc cccgcttggg ctttgaggga ggccagactc cattttacat ccgaatccca    300

aaatacgggt ttaacgaagg acatagtttc agacgccagt ataagccttt gagtctcaat    360

agactgcagt atcttattga tttgggtcgt gttgatccta gtcaacctat tgacttaacc    420

cagcttgtca atgggagagg tgtgaccatc cagccactta aaagggatta tggtgtccag    480

ctggttgagg agggtgctga cacctttacg gcaaaagtta atattgaagt acagttggct    540

tcagaactag ctattgctgc cattgaaaaa aatggtggtg ttgttactac agccttctat    600

gatccaagaa gtctggacat tgtatgcaaa cctgttccat tctttcttcg tggacaaccc    660

attccaaaaa gaatgcttcc accagaagaa ctggtaccat attacactga tgcaaagaac    720

cgtgggtacc tggcggatcc tgccaaattt cctgaagcac gacttgaact cgccaggaag    780

tatggttata tcttacctga tatcactaaa gatgaactct tcaaaatgct ctgtactagg    840

aaggatccaa ggcagatttt ctttggtctt gctccaggat gggtggtgaa tatggccgat    900

aagaaaatcc taaaacctac agatgaaaat ctccttaagt attatacctc atgaattccc    960

gtccaaggaa gcagagttgt taaagagtac tggaataggg gctgaaggat ctatattccc   1020

ttattgcatt ttccttatgt ataattttcc agatggtgat gttacttttc agtgtactca   1080

tatgtctcat tttcatctaa aattaaatgg caggaaacaa ggactgcata gagaaaaaaa   1140

aaaaaaaaaa aaaaa                                                    1155


<210>  2278
<211>  296
<212>  PRT
<213>  Homosapiens

<400>  2278

Met Ala Gly Pro Leu Gln Gly Gly Gly Ala Arg Ala Leu Asp Leu Leu 
1               5                   10                  15      


Arg Gly Leu Pro Arg Val Ser Leu Ala Asn Leu Lys Pro Asn Pro Gly 
            20                  25                  30          


Ser Lys Lys Pro Glu Arg Arg Pro Arg Gly Arg Arg Arg Gly Arg Lys 
        35                  40                  45              


Cys Gly Arg Gly His Lys Gly Glu Arg Gln Arg Gly Thr Arg Pro Arg 
    50                  55                  60                  


Leu Gly Phe Glu Gly Gly Gln Thr Pro Phe Tyr Ile Arg Ile Pro Lys 
65                  70                  75                  80  


Tyr Gly Phe Asn Glu Gly His Ser Phe Arg Arg Gln Tyr Lys Pro Leu 
                85                  90                  95      


Ser Leu Asn Arg Leu Gln Tyr Leu Ile Asp Leu Gly Arg Val Asp Pro 
            100                 105                 110         


Ser Gln Pro Ile Asp Leu Thr Gln Leu Val Asn Gly Arg Gly Val Thr 
        115                 120                 125             


Ile Gln Pro Leu Lys Arg Asp Tyr Gly Val Gln Leu Val Glu Glu Gly 
    130                 135                 140                 


Ala Asp Thr Phe Thr Ala Lys Val Asn Ile Glu Val Gln Leu Ala Ser 
145                 150                 155                 160 


Glu Leu Ala Ile Ala Ala Ile Glu Lys Asn Gly Gly Val Val Thr Thr 
                165                 170                 175     


Ala Phe Tyr Asp Pro Arg Ser Leu Asp Ile Val Cys Lys Pro Val Pro 
            180                 185                 190         


Phe Phe Leu Arg Gly Gln Pro Ile Pro Lys Arg Met Leu Pro Pro Glu 
        195                 200                 205             


Glu Leu Val Pro Tyr Tyr Thr Asp Ala Lys Asn Arg Gly Tyr Leu Ala 
    210                 215                 220                 


Asp Pro Ala Lys Phe Pro Glu Ala Arg Leu Glu Leu Ala Arg Lys Tyr 
225                 230                 235                 240 


Gly Tyr Ile Leu Pro Asp Ile Thr Lys Asp Glu Leu Phe Lys Met Leu 
                245                 250                 255     


Cys Thr Arg Lys Asp Pro Arg Gln Ile Phe Phe Gly Leu Ala Pro Gly 
            260                 265                 270         


Trp Val Val Asn Met Ala Asp Lys Lys Ile Leu Lys Pro Thr Asp Glu 
        275                 280                 285             


Asn Leu Leu Lys Tyr Tyr Thr Ser 
    290                 295     


<210>  2279
<211>  501
<212>  DNA
<213>  Homosapiens

<400>  2279
atgccacgtg gaagccgaag ccacacctcc tacagggccc ctcccaccag ccaggcacct     60

cagatgagag ctacacccag gctagcacca gcagctcagc cgccagcagt ggcaccccca    120

tctgcagttg gctctcctgc tcctgcaccc cggcagccaa gtctgatggc ccaaatggca    180

accactgcag ctggcgtggc tgtaggctct gctgtgggtc acacactggg ttatgccctc    240

actgggagct tcagtggagg aagtaatggt gagcctgcaa aacttgacat cacttaccag    300

cagcatcagg gaacctggcc agcacagcag cagcagcctt gtttccatga gatcaaacag    360

tttttggagt gtgcccagaa ccagggtgac accaacaagc tctgtggggc tttcaagagg    420

ttctcaaaca gtgcagactt gcaaacagat aggcctaatc aagaagttca aattggagaa    480

atggaaaatc agctctccta a                                              501


<210>  2280
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  2280

Met Pro Arg Gly Ser Arg Ser His Thr Ser Tyr Arg Ala Pro Pro Thr 
1               5                   10                  15      


Ser Gln Ala Pro Gln Met Arg Ala Thr Pro Arg Leu Ala Pro Ala Ala 
            20                  25                  30          


Gln Pro Pro Ala Val Ala Pro Pro Ser Ala Val Gly Ser Pro Ala Pro 
        35                  40                  45              


Ala Pro Arg Gln Pro Ser Leu Met Ala Gln Met Ala Thr Thr Ala Ala 
    50                  55                  60                  


Gly Val Ala Val Gly Ser Ala Val Gly His Thr Leu Gly Tyr Ala Leu 
65                  70                  75                  80  


Thr Gly Ser Phe Ser Gly Gly Ser Asn Gly Glu Pro Ala Lys Leu Asp 
                85                  90                  95      


Ile Thr Tyr Gln Gln His Gln Gly Thr Trp Pro Ala Gln Gln Gln Gln 
            100                 105                 110         


Pro Cys Phe His Glu Ile Lys Gln Phe Leu Glu Cys Ala Gln Asn Gln 
        115                 120                 125             


Gly Asp Thr Asn Lys Leu Cys Gly Ala Phe Lys Arg Phe Ser Asn Ser 
    130                 135                 140                 


Ala Asp Leu Gln Thr Asp Arg Pro Asn Gln Glu Val Gln Ile Gly Glu 
145                 150                 155                 160 


Met Glu Asn Gln Leu Ser 
                165     


<210>  2281
<211>  2317
<212>  DNA
<213>  Homosapiens

<400>  2281
aaatctgtcc gcccccttgg ccactgatcc cccgaagagc ttctgtcgcc gctctaggaa     60

tagagacatt gaagtttggg acaagatatt tatctaactt ctgtgtcaaa attagcgacc    120

tgctatggca atgaagaaag aaactgaatt tgtcattttc acctgaagaa aaatgataga    180

caaaaatcaa acctgtggtg taggacagga ttctgtgccc tatatgattt gtctgattca    240

catactcgaa gaatggtttg gtgtggagca gttggaggac tatttgaatt ttgcaaacta    300

tctcttgtgg gtttttacac cactaatact tttaatactt ccttacttta ctatctttct    360

tctctacctt actattattt tcttacacat ttataagaga aagaatgtat tgaaagaagc    420

ctactctcat aatttatggg atggtgcaag gaaaacagtg gcaactctgt gggatggaca    480

tgcagccgtt tggcatggtt atgaagttca tggaatggaa aaaataccag aagatggacc    540

agcacttata attttttatc atggagctat tcctatagat ttttactatt tcatggctaa    600

aatatttata cacaaaggca gaacttgccg agtagtagct gatcactttg tctttaaaat    660

tccagggttt agtttattac tggatgtgtt ttgtgctcta catggaccaa gagaaaaatg    720

tgttgaaatt ctgaggagtg gccacttgtt agctatctca ccaggtggag ttcgagaagc    780

cctaattagt gatgaaactt ataacatcgt atggggtcat cgcagaggct ttgctcaggt    840

tgcaattgat gcaaaagtga cgaagaatgc tgttcaagct ttgattgata agcaccaaag    900

aataccagga aacattatga gtgctttgtt agaacgtttt cattgataac aaagggtcaa    960

ctagaagatg atttagtaca tttatattaa atgtttgtat ctaaggtact gtcttctgaa   1020

ttttgtaggt cctataatta gtatttttta aaaaaatcat gttaataagc atctttcaca   1080

gaattcgttt ctttaaaata gtcaattttg tttttgcaat tgtgtcaaat actaacaaat   1140

tacacaccta gtaattcaga aaaagatgtc ttatttgtaa attcctaaca atttatgcta   1200

aacatataga ttcttaagtt tattaataac agcagtttag gttaaacaaa cattcctgga   1260

taatgcgtta aatttctgta tctgtcgccc tgagctgatt ttgaaagatg gtataagcta   1320

ggggttagta tagttgttta agttagaaaa aacatgctgt tgtctgcccc tcattccctt   1380

catgaccttg ggcaagtcac gtaatgtttt tgtgcctcaa caattcactt tttaaaaaca   1440

tgatcgtatg atgaatgata ttattttgtt atttatattt actgtgattg ataactgttg   1500

aaccaaaata ataaaataat taatttaaac aatgtcaaaa tcctttagca gttatgtata   1560

tattttctcc attgtgtgtt taaattatgt catgtccagt tgccaagcac aatgaaaaag   1620

atgtattatt ttttaaattg aataaaaaat taggaaaaat aaaatttcta attattattt   1680

ttagtatgat atttttaaca agagtctata ggcaaacaat atagggtgtg ctgtgcattg   1740

tcagccctat actgtggtct taataatgcc agcttaaaaa tcactgttgt gctctgcatt   1800

tcgtgtgtta gaagctgatt ctaggctgag gaaagcaaga gttctctact tttgctcaat   1860

attgaggctt acccagtttg actctacagc cagtgaagtg gtttattgct tcaataaaaa   1920

tatacttgaa tgatgaattt atttatgttt tgttttgttt ttatttagag atggggtttt   1980

gccatgttgg ccaggctggt cttgaactcc tgacctcagg tgatccacct gcctcagcct   2040

cccaacttgc tgggattaca ggtgtgagcc accatgccca gcctgaatga tgaatttatg   2100

tgaacacaaa gccctctgaa aaattaatga ttttcaattt gttgtcttct tgaaaactga   2160

atttaagtat tatttaaaca gaaaagtgtc agaaatcaaa tgcagtatct ccctctccct   2220

tttttaaatg ttgaattagt agggtttttg tatagctttt tgtattgtgt gtatttatga   2280

tatgtgaaat gtacataaaa ttaaacaatg tgaaaat                            2317


<210>  2282
<211>  257
<212>  PRT
<213>  Homosapiens

<400>  2282

Met Ile Asp Lys Asn Gln Thr Cys Gly Val Gly Gln Asp Ser Val Pro 
1               5                   10                  15      


Tyr Met Ile Cys Leu Ile His Ile Leu Glu Glu Trp Phe Gly Val Glu 
            20                  25                  30          


Gln Leu Glu Asp Tyr Leu Asn Phe Ala Asn Tyr Leu Leu Trp Val Phe 
        35                  40                  45              


Thr Pro Leu Ile Leu Leu Ile Leu Pro Tyr Phe Thr Ile Phe Leu Leu 
    50                  55                  60                  


Tyr Leu Thr Ile Ile Phe Leu His Ile Tyr Lys Arg Lys Asn Val Leu 
65                  70                  75                  80  


Lys Glu Ala Tyr Ser His Asn Leu Trp Asp Gly Ala Arg Lys Thr Val 
                85                  90                  95      


Ala Thr Leu Trp Asp Gly His Ala Ala Val Trp His Gly Tyr Glu Val 
            100                 105                 110         


His Gly Met Glu Lys Ile Pro Glu Asp Gly Pro Ala Leu Ile Ile Phe 
        115                 120                 125             


Tyr His Gly Ala Ile Pro Ile Asp Phe Tyr Tyr Phe Met Ala Lys Ile 
    130                 135                 140                 


Phe Ile His Lys Gly Arg Thr Cys Arg Val Val Ala Asp His Phe Val 
145                 150                 155                 160 


Phe Lys Ile Pro Gly Phe Ser Leu Leu Leu Asp Val Phe Cys Ala Leu 
                165                 170                 175     


His Gly Pro Arg Glu Lys Cys Val Glu Ile Leu Arg Ser Gly His Leu 
            180                 185                 190         


Leu Ala Ile Ser Pro Gly Gly Val Arg Glu Ala Leu Ile Ser Asp Glu 
        195                 200                 205             


Thr Tyr Asn Ile Val Trp Gly His Arg Arg Gly Phe Ala Gln Val Ala 
    210                 215                 220                 


Ile Asp Ala Lys Val Thr Lys Asn Ala Val Gln Ala Leu Ile Asp Lys 
225                 230                 235                 240 


His Gln Arg Ile Pro Gly Asn Ile Met Ser Ala Leu Leu Glu Arg Phe 
                245                 250                 255     


His 
    


<210>  2283
<211>  3798
<212>  DNA
<213>  Homosapiens

<400>  2283
tgggagaccg gacgcgcgcg gcctccgccg ctcccagtcc cgccagaccc gatgccgggc     60

tggagaagcg cgggggccga cgcacctcgg ataggcgggg gcaggggcag gggcagctct    120

cctttaccct agagcggcga cagaagctct tcgggggatc agtggccaag ggggcggaca    180

gatttgcacg gcggattcct ccgaagcaac ccgtgtgaaa gaagccaagc ggaggctgca    240

gcccgggccg cgatgggggt gacaccgccc gtggtcccgc cccttcccgt ggcccctcgg    300

agccacttcc ggcggcagcg tccgggctag ttcctggcgc gagcggccgc gggccagttt    360

ctatctcctc atccagggct tgcgggcgag gcctgtttta agtctccagt aaccgagcgg    420

aggcccggca ggcgcgaccc gggctgcgta cgtcagagct gcctccgaag tggtaaaatg    480

tgctgcgaga agtggagccg cgtggcggaa atgtttctct tcactgagga gcgggaggat    540

tgtaagatac tgtgcctttg ctccagggca tttgtggagg atcgaaaatt gtacaatttg    600

ggattaaaag gctattacat cagagacagt ggcaacaatt caggagacca ggcgacagaa    660

gaagaggaag gtggttattc ctgtggtact gcagaatcac atgacagcaa aggcataggc    720

ctggatgaaa gtgaacttga ttctgaggct gaactcatga gaagtatggg attgccactt    780

caatttggta ggataactgc acataaggat tttgaggtat ctatgaatac tagaaataaa    840

gttaaaataa aaaagaaaaa acatcaaaag aaatacttag atgaaattgt gcaagaatct    900

tggagaaaag aatatgaaga agacgacatt ttggcttcag atgatccatc ttcaattgaa    960

cagtatgaga acaccagaac atatgaactt caaagcaaaa aagatactga gacagaaaat   1020

cctccagttg aaaacacatt atctccaaag ctagaaatta cagagaaatg ggaaaagtat   1080

tggaatgaat atggaggagg actattgtgg caaagttggc aagaaaaaca tccgggtcaa   1140

gcactatctt ctgaaccttg gaactttcct gatacaaagg aagaatggga gcaacattat   1200

agtcaacttt attggtatta tttggaacaa tttcagtatt gggaagctca gggttggact   1260

tttgatgcct cgcaaagctg tgatacagat acttacacat ctaaaacaga agctgatgac   1320

aagaacgatg aaaaatgcat gaaagttgac ttagtatctt ttccatcttc acctattatg   1380

gttgataatg atagctctgg tacaagtgat aaggatcata gtgaaatact tgatggaatt   1440

agtaacataa aactgaattc agaggaagta acacagagcc aattagattc ctgtacaagt   1500

catgatggtc atcaacagct aagtgaagtt agtagcaaaa gagagtgccc tgcttccggc   1560

caaagtgaac cacgtaatgg aggaaccaat gaggaaagca actcatcggg gaatacaaac   1620

acagacccac cagctgagga ttcacagaag tcttcaggag caaacacaag caaagacaga   1680

ccacatgcca gtggtactga tggagatgaa agtgaggaag acccacctga gcataagcca   1740

agcaaactga agaggagcca tgaactggac attgatgaaa acccagcttc agactttgat   1800

gacagtggtt cccttctagg attcaagtat ggctcaggac aaaaatatgg tggaatccca   1860

aatttcagtc atcggcaggt caggtattta gagaagaatg tgaagcttaa gtctaagtac   1920

ctagacatgc gcagacaaat aaagatgaaa aacaaacaca tcttctttac caaagagtca   1980

gaaaaaccat ttttcaagaa aagcaaaatt ctgagtaagg tagaaaaatt cctcacatgg   2040

gttaataaac caatggatga agaagcatca caggaatcat cttctcatga caatgtgcac   2100

gacgcttcca caagtagtga ttcagaggaa caagacatgt ctgttaaaaa aggtgatgac   2160

ctactggaga ctaataatcc agaacctgaa aagtgtcaga gcgtatcttc agctggtgaa   2220

cttgaaacag aaaactatga aagagacagc ttgctagcaa ctgttccaga tgagcaggat   2280

tgtgttactc aagaagtgcc agactcccgc caggcagaaa ctgaagctga agtgaaaaag   2340

aagaagacca agaagaagac caaaaaggtg aatggtctgc ctcctgaaat agctgctgtt   2400

cctgagctgg caaaatactg ggcccagagg tacaggctct tctcccgttt tgatgatggg   2460

attaagttgg acagagaggg ctggttttca gttacacccg agaagattgc tgaacacatt   2520

gctggccgtg ttagtcagtc cttcaagtgt gacgttgtag tagacgcatt ctgtggagtt   2580

ggaggaaata ccattcagtt tgccttaaca ggaatgagag tgattgccat tgatatcgat   2640

cctgttaaga ttgcccttgc tcgcaataat gcagaagttt atgggatagc agataagata   2700

gagttcatct gtggagattt cttgctgctg gcttcttttt taaaggctga tgttgtgttc   2760

ctcagcccac cttggggagg gccagactat gccactgcag agacctttga cattagaaca   2820

atgatgtctc ctgatggctt tgaaattttc agactttcta agaagatcac taataatatt   2880

gtttattttc ttccaagaaa tgctgatatt gaccaggtgg catccttagc tgggcctgga   2940

gggcaagtgg aaatagaaca gaacttcctt aacaacaaat tgaagacaat cactgcatat   3000

tttggtgacc taattcgaag accagcctct gaaacctaac tatgcagcag tgcgaggaca   3060

aaagatcatg gagtggtcaa aatattcaga tgagacattt ggcatgtctt cctttattca   3120

ctgatatttt ctacccatgg tcttatatca ccgtatgaaa tggaaactta caggacttaa   3180

atatcagtga aatattttga gatctttgaa taattccttt agaggaatta tacaaaatta   3240

atatatatga gtcctttgta atttattttt ttttgagaca ggatctcact tttaccgccc   3300

aggctggagt gcagtgccat gatcacagct cactgcaggt tcagccttct gagttcaagc   3360

aatccttctg tctcagtctc ctcagtagct ggggctttag gtgggcactg ccacaccgta   3420

ctaatttttg tattttttgt agagacgagg tcccaccatg ttgcccaggc tggtgtcaaa   3480

ctcctgggct cagtcagtcc ccccatctca ccctccccaa gtgctggaat tacaggcgtg   3540

agctactgtg cccagcctta cggacatcct tttgaattat ctttttcact catagaatat   3600

gaatacattt atttagactt tttctagaac tttcctgttt tcatgtcttt gcttcatctg   3660

gaattggctt aacacccttt tataaagttt gtgtttgtaa aatttccatt gtgacatcaa   3720

tacgcaatat attttgtaat ataggagttt ctattttttt attaaaatgg caatgaaagc   3780

aaaaaaaaaa aaaaaaaa                                                 3798


<210>  2284
<211>  853
<212>  PRT
<213>  Homosapiens

<400>  2284

Met Cys Cys Glu Lys Trp Ser Arg Val Ala Glu Met Phe Leu Phe Thr 
1               5                   10                  15      


Glu Glu Arg Glu Asp Cys Lys Ile Leu Cys Leu Cys Ser Arg Ala Phe 
            20                  25                  30          


Val Glu Asp Arg Lys Leu Tyr Asn Leu Gly Leu Lys Gly Tyr Tyr Ile 
        35                  40                  45              


Arg Asp Ser Gly Asn Asn Ser Gly Asp Gln Ala Thr Glu Glu Glu Glu 
    50                  55                  60                  


Gly Gly Tyr Ser Cys Gly Thr Ala Glu Ser His Asp Ser Lys Gly Ile 
65                  70                  75                  80  


Gly Leu Asp Glu Ser Glu Leu Asp Ser Glu Ala Glu Leu Met Arg Ser 
                85                  90                  95      


Met Gly Leu Pro Leu Gln Phe Gly Arg Ile Thr Ala His Lys Asp Phe 
            100                 105                 110         


Glu Val Ser Met Asn Thr Arg Asn Lys Val Lys Ile Lys Lys Lys Lys 
        115                 120                 125             


His Gln Lys Lys Tyr Leu Asp Glu Ile Val Gln Glu Ser Trp Arg Lys 
    130                 135                 140                 


Glu Tyr Glu Glu Asp Asp Ile Leu Ala Ser Asp Asp Pro Ser Ser Ile 
145                 150                 155                 160 


Glu Gln Tyr Glu Asn Thr Arg Thr Tyr Glu Leu Gln Ser Lys Lys Asp 
                165                 170                 175     


Thr Glu Thr Glu Asn Pro Pro Val Glu Asn Thr Leu Ser Pro Lys Leu 
            180                 185                 190         


Glu Ile Thr Glu Lys Trp Glu Lys Tyr Trp Asn Glu Tyr Gly Gly Gly 
        195                 200                 205             


Leu Leu Trp Gln Ser Trp Gln Glu Lys His Pro Gly Gln Ala Leu Ser 
    210                 215                 220                 


Ser Glu Pro Trp Asn Phe Pro Asp Thr Lys Glu Glu Trp Glu Gln His 
225                 230                 235                 240 


Tyr Ser Gln Leu Tyr Trp Tyr Tyr Leu Glu Gln Phe Gln Tyr Trp Glu 
                245                 250                 255     


Ala Gln Gly Trp Thr Phe Asp Ala Ser Gln Ser Cys Asp Thr Asp Thr 
            260                 265                 270         


Tyr Thr Ser Lys Thr Glu Ala Asp Asp Lys Asn Asp Glu Lys Cys Met 
        275                 280                 285             


Lys Val Asp Leu Val Ser Phe Pro Ser Ser Pro Ile Met Val Asp Asn 
    290                 295                 300                 


Asp Ser Ser Gly Thr Ser Asp Lys Asp His Ser Glu Ile Leu Asp Gly 
305                 310                 315                 320 


Ile Ser Asn Ile Lys Leu Asn Ser Glu Glu Val Thr Gln Ser Gln Leu 
                325                 330                 335     


Asp Ser Cys Thr Ser His Asp Gly His Gln Gln Leu Ser Glu Val Ser 
            340                 345                 350         


Ser Lys Arg Glu Cys Pro Ala Ser Gly Gln Ser Glu Pro Arg Asn Gly 
        355                 360                 365             


Gly Thr Asn Glu Glu Ser Asn Ser Ser Gly Asn Thr Asn Thr Asp Pro 
    370                 375                 380                 


Pro Ala Glu Asp Ser Gln Lys Ser Ser Gly Ala Asn Thr Ser Lys Asp 
385                 390                 395                 400 


Arg Pro His Ala Ser Gly Thr Asp Gly Asp Glu Ser Glu Glu Asp Pro 
                405                 410                 415     


Pro Glu His Lys Pro Ser Lys Leu Lys Arg Ser His Glu Leu Asp Ile 
            420                 425                 430         


Asp Glu Asn Pro Ala Ser Asp Phe Asp Asp Ser Gly Ser Leu Leu Gly 
        435                 440                 445             


Phe Lys Tyr Gly Ser Gly Gln Lys Tyr Gly Gly Ile Pro Asn Phe Ser 
    450                 455                 460                 


His Arg Gln Val Arg Tyr Leu Glu Lys Asn Val Lys Leu Lys Ser Lys 
465                 470                 475                 480 


Tyr Leu Asp Met Arg Arg Gln Ile Lys Met Lys Asn Lys His Ile Phe 
                485                 490                 495     


Phe Thr Lys Glu Ser Glu Lys Pro Phe Phe Lys Lys Ser Lys Ile Leu 
            500                 505                 510         


Ser Lys Val Glu Lys Phe Leu Thr Trp Val Asn Lys Pro Met Asp Glu 
        515                 520                 525             


Glu Ala Ser Gln Glu Ser Ser Ser His Asp Asn Val His Asp Ala Ser 
    530                 535                 540                 


Thr Ser Ser Asp Ser Glu Glu Gln Asp Met Ser Val Lys Lys Gly Asp 
545                 550                 555                 560 


Asp Leu Leu Glu Thr Asn Asn Pro Glu Pro Glu Lys Cys Gln Ser Val 
                565                 570                 575     


Ser Ser Ala Gly Glu Leu Glu Thr Glu Asn Tyr Glu Arg Asp Ser Leu 
            580                 585                 590         


Leu Ala Thr Val Pro Asp Glu Gln Asp Cys Val Thr Gln Glu Val Pro 
        595                 600                 605             


Asp Ser Arg Gln Ala Glu Thr Glu Ala Glu Val Lys Lys Lys Lys Thr 
    610                 615                 620                 


Lys Lys Lys Thr Lys Lys Val Asn Gly Leu Pro Pro Glu Ile Ala Ala 
625                 630                 635                 640 


Val Pro Glu Leu Ala Lys Tyr Trp Ala Gln Arg Tyr Arg Leu Phe Ser 
                645                 650                 655     


Arg Phe Asp Asp Gly Ile Lys Leu Asp Arg Glu Gly Trp Phe Ser Val 
            660                 665                 670         


Thr Pro Glu Lys Ile Ala Glu His Ile Ala Gly Arg Val Ser Gln Ser 
        675                 680                 685             


Phe Lys Cys Asp Val Val Val Asp Ala Phe Cys Gly Val Gly Gly Asn 
    690                 695                 700                 


Thr Ile Gln Phe Ala Leu Thr Gly Met Arg Val Ile Ala Ile Asp Ile 
705                 710                 715                 720 


Asp Pro Val Lys Ile Ala Leu Ala Arg Asn Asn Ala Glu Val Tyr Gly 
                725                 730                 735     


Ile Ala Asp Lys Ile Glu Phe Ile Cys Gly Asp Phe Leu Leu Leu Ala 
            740                 745                 750         


Ser Phe Leu Lys Ala Asp Val Val Phe Leu Ser Pro Pro Trp Gly Gly 
        755                 760                 765             


Pro Asp Tyr Ala Thr Ala Glu Thr Phe Asp Ile Arg Thr Met Met Ser 
    770                 775                 780                 


Pro Asp Gly Phe Glu Ile Phe Arg Leu Ser Lys Lys Ile Thr Asn Asn 
785                 790                 795                 800 


Ile Val Tyr Phe Leu Pro Arg Asn Ala Asp Ile Asp Gln Val Ala Ser 
                805                 810                 815     


Leu Ala Gly Pro Gly Gly Gln Val Glu Ile Glu Gln Asn Phe Leu Asn 
            820                 825                 830         


Asn Lys Leu Lys Thr Ile Thr Ala Tyr Phe Gly Asp Leu Ile Arg Arg 
        835                 840                 845             


Pro Ala Ser Glu Thr 
    850             


<210>  2285
<211>  2298
<212>  DNA
<213>  Homosapiens

<400>  2285
tcggccgagc ccagagacag ccagttcctc tcccgccgcg ccgggccgcg tgccgctcgc     60

tccccggccg tggcgcctcc gggccagacg cgctgcagcc tccagcccgc ggcaagcggg    120

cggggcggcc gcgccacccc cggccccgcg ccagcagccc ctcgccgcgc gtccagcgtt    180

cccggccagc agcctcccca tacgcagtcc tgctggaccg ccccgtcgcg ccccccactc    240

tgaactcaag tcaccgtgga gctccgccgc cccgaaactt tcacgcgagc gggaaatatg    300

ggatgtataa aatcaaaagg gaaagacagc ttgagtgacg atggagtaga tttgaagact    360

caaccagtac gtaatactga aagaactatt tatgtgagag atccaacgtc caataaacag    420

caaaggccag ttccagaatc tcagctttta cctggacaga ggtttcaaac taaagatcca    480

gaggaacaag gagacattgt ggtagccttg tacccctatg atggcatcca cccggacgac    540

ttgtctttca agaaaggaga gaagatgaaa gtcctggagg agcatggaga atggtggaaa    600

gcaaagtccc ttttaacaaa aaaagaaggc ttcatcccca gcaactatgt ggccaaactc    660

aacaccttag aaacagaaga gtggtttttc aaggatataa ccaggaagga cgcagaaagg    720

cagcttttgg caccaggaaa tagcgctgga gctttcctta ttagagaaag tgaaacatta    780

aaaggaagct tctctctgtc tgtcagagac tttgaccctg tgcatggtga tgttattaag    840

cactacaaaa ttagaagtct ggataatggg ggctattaca tctctccacg aatcactttt    900

ccctgtatca gcgacatgat taaacattac caaaagcagg cagatggctt gtgcagaaga    960

ttggagaagg cttgtattag tcccaagcca cagaagccat gggataaaga tgcctgggag   1020

atcccccggg agtccatcaa gttggtgaaa aggcttggcg ctgggcagtt tggggaagtc   1080

tggatgggtt actataacaa cagtaccaag gtggctgtga aaaccctgaa gccaggaact   1140

atgtctgtgc aagccttcct ggaagaagcc aacctcatga agaccctgca gcatgacaag   1200

ctcgtgaggc tctacgctgt ggtcaccagg gaggagccca tttacatcat caccgagtac   1260

atggccaagg gcagtttgct ggatttcctg aagagcgatg aaggtggcaa agtgctgctt   1320

ccaaagctca ttgacttttc tgctcagatt gcagagggaa tggcatacat cgagcggaag   1380

aactacattc accgggacct gcgagcagct aatgttctgg tctccgagtc actaatgtgc   1440

aaaattgcag attttggcct tgctagagta attgaagata atgagtacac agcaagggaa   1500

ggtgctaagt tccctattaa gtggacggct ccagaagcaa tcaactttgg atgtttcact   1560

attaagtctg atgtgtggtc ctttggaatc ctcctatacg aaattgtcac ctatgggaaa   1620

attccctacc cagggagaac taatgccgac gtgatgaccg ccctgtccca gggctacagg   1680

atgccccgtg tggagaactg cccagatgag ctctatgaca ttatgaaaat gtgctggaaa   1740

gaaaaggcag aagagagacc aacgtttgac tacttacaga gcgtcctgga tgatttctac   1800

acagccacgg aagggcaata ccagcagcag ccttagagca cagggagacc cgtccatttg   1860

gcaggggtgg ctgcctcatt tagagaggaa aagtaaccat cactggttgc acttatgatt   1920

tcatgtgcgg ggatcatctg ccgtgcctgg atcctgaaat agaggctaaa ttactcagga   1980

agaacaccct ctaaatggga aagtattctg tactcttaga tggattctcc actcagttgc   2040

aacttggact tgtcctcagc agctggtaat cttgctctgc ttgacaacat ctgagtgcag   2100

ccgtttgaga agaaaacatc tattctctcc aaaaatgcac ccaactagct ctatgtttac   2160

aaatggacat aggactcaaa gtttcagaga ccattgcaat gaatccccaa taattgcaga   2220

actaaactca tttataaagc taaaataacc ggatatatac atagcatgac atttctttgt   2280

gctttggctt acttgttt                                                 2298


<210>  2286
<211>  512
<212>  PRT
<213>  Homosapiens

<400>  2286

Met Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Leu Ser Asp Asp Gly 
1               5                   10                  15      


Val Asp Leu Lys Thr Gln Pro Val Arg Asn Thr Glu Arg Thr Ile Tyr 
            20                  25                  30          


Val Arg Asp Pro Thr Ser Asn Lys Gln Gln Arg Pro Val Pro Glu Ser 
        35                  40                  45              


Gln Leu Leu Pro Gly Gln Arg Phe Gln Thr Lys Asp Pro Glu Glu Gln 
    50                  55                  60                  


Gly Asp Ile Val Val Ala Leu Tyr Pro Tyr Asp Gly Ile His Pro Asp 
65                  70                  75                  80  


Asp Leu Ser Phe Lys Lys Gly Glu Lys Met Lys Val Leu Glu Glu His 
                85                  90                  95      


Gly Glu Trp Trp Lys Ala Lys Ser Leu Leu Thr Lys Lys Glu Gly Phe 
            100                 105                 110         


Ile Pro Ser Asn Tyr Val Ala Lys Leu Asn Thr Leu Glu Thr Glu Glu 
        115                 120                 125             


Trp Phe Phe Lys Asp Ile Thr Arg Lys Asp Ala Glu Arg Gln Leu Leu 
    130                 135                 140                 


Ala Pro Gly Asn Ser Ala Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr 
145                 150                 155                 160 


Leu Lys Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Pro Val His 
                165                 170                 175     


Gly Asp Val Ile Lys His Tyr Lys Ile Arg Ser Leu Asp Asn Gly Gly 
            180                 185                 190         


Tyr Tyr Ile Ser Pro Arg Ile Thr Phe Pro Cys Ile Ser Asp Met Ile 
        195                 200                 205             


Lys His Tyr Gln Lys Gln Ala Asp Gly Leu Cys Arg Arg Leu Glu Lys 
    210                 215                 220                 


Ala Cys Ile Ser Pro Lys Pro Gln Lys Pro Trp Asp Lys Asp Ala Trp 
225                 230                 235                 240 


Glu Ile Pro Arg Glu Ser Ile Lys Leu Val Lys Arg Leu Gly Ala Gly 
                245                 250                 255     


Gln Phe Gly Glu Val Trp Met Gly Tyr Tyr Asn Asn Ser Thr Lys Val 
            260                 265                 270         


Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Val Gln Ala Phe Leu 
        275                 280                 285             


Glu Glu Ala Asn Leu Met Lys Thr Leu Gln His Asp Lys Leu Val Arg 
    290                 295                 300                 


Leu Tyr Ala Val Val Thr Arg Glu Glu Pro Ile Tyr Ile Ile Thr Glu 
305                 310                 315                 320 


Tyr Met Ala Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly 
                325                 330                 335     


Gly Lys Val Leu Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala 
            340                 345                 350         


Glu Gly Met Ala Tyr Ile Glu Arg Lys Asn Tyr Ile His Arg Asp Leu 
        355                 360                 365             


Arg Ala Ala Asn Val Leu Val Ser Glu Ser Leu Met Cys Lys Ile Ala 
    370                 375                 380                 


Asp Phe Gly Leu Ala Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg 
385                 390                 395                 400 


Glu Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn 
                405                 410                 415     


Phe Gly Cys Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu 
            420                 425                 430         


Leu Tyr Glu Ile Val Thr Tyr Gly Lys Ile Pro Tyr Pro Gly Arg Thr 
        435                 440                 445             


Asn Ala Asp Val Met Thr Ala Leu Ser Gln Gly Tyr Arg Met Pro Arg 
    450                 455                 460                 


Val Glu Asn Cys Pro Asp Glu Leu Tyr Asp Ile Met Lys Met Cys Trp 
465                 470                 475                 480 


Lys Glu Lys Ala Glu Glu Arg Pro Thr Phe Asp Tyr Leu Gln Ser Val 
                485                 490                 495     


Leu Asp Asp Phe Tyr Thr Ala Thr Glu Gly Gln Tyr Gln Gln Gln Pro 
            500                 505                 510         


<210>  2287
<211>  4058
<212>  DNA
<213>  Homosapiens

<400>  2287
ccaatgttgg agccgtctgc aaagtgtccc cggcaagaag aggctgccta ccacaaggac     60

tttagcttac tttttaaaga ttgaagaaaa aaaagaagac agaaaaagaa gaactcaaag    120

atacacaaag taatttgaac caaggctcag aagtttttgg agccgtgagg gatacagcag    180

tttggtcaat attgtcttaa catgcttcaa ataaatcaga tgttctcagt gcagctgagt    240

cttggtgagc agacatggga atccgaaggc agcagtataa agaaggctca gcaggctgtt    300

gccaataaag ctttgactga atctacgctt cccaaaccag ttcagaagcc acccaaaagt    360

aatgttaaca ataacccagg cagtataact ccaactgtgg aactgaatgg gcttgctatg    420

aaaaggggag agcctgccat ctacaggcca ttagatccaa agccattccc aaattataga    480

gctaattaca actttcgggg catgtacaat cagaggtatc attgcccagt gcctaagatc    540

ttttatgttc agctcactgt aggaaataat gaattttttg gggaaggaaa gactcgacaa    600

gctgctagac acaatgctgc aatgaaagcc ctccaagcac tgcagaatga acctattcca    660

gaaagatctc ctcagaatgg tgaatcagga aaggatatgg atgatgacaa agatgcaaat    720

aagtctgaga tcagcttagt gtttgaaatt gctctgaagc gaaatatgcc tgtcagtttt    780

gaggttatta aagaaagtgg accaccacat atgaaaagct ttgttactcg agtgtcagta    840

ggagagttct ctgcagaagg agaaggaaat agcaaaaaac tctccaagaa gcgcgctgcg    900

accaccgtct tacaggagct taaaaaactt ccacctcttc ctgtggtgga aaagccaaaa    960

ctatttttta aaaaacgccc taaaacaata gtaaaggccg gaccagaata tggccaaggg   1020

atgaacccta ttagccgcct ggcgcaaatt caacaggcca aaaaggaaaa ggagccggat   1080

tatgttttgc tttcagaaag aggaatgcct cgacgtcgag aatttgtgat gcaggtgaag   1140

gtaggcaatg aagttgctac aggaacagga cctaataaaa agatagccaa aaaaaatgct   1200

gcagaagcaa tgctgttaca acttggttat aaagcatcca ctaatcttca ggatcaactt   1260

gagaagacag gggaaaacaa aggatggagt ggtccaaagc ctgggtttcc tgaaccaaca   1320

aataatactc caaaaggaat tcttcatttg tctcctgatg tttatcaaga gatggaagcc   1380

agccgccaca aagtaatctc tggcactact ctaggctatt tgtcacccaa agatatgaac   1440

caaccttcaa gctctttctt cagtatatct cccacatcga atagttcagc tacaattgcc   1500

agggaactcc ttatgaatgg aacatcttct acagctgaag ccataggttt aaaaggaagt   1560

tctcctactc ccccttgttc tccagtacaa ccttcaaaac aactggaata tttagcaagg   1620

attcaaggct ttcaggtatg aattaaaagc aaaaacaaaa aacaaaacaa ttcattagcc   1680

tcagattctt catctgtata catcacaagg ctcattcttg cctgctagta tggcctacat   1740

gccacttacg ttttaagtta tttaggaaca caaaggacag acaaaaaagc catatgcaca   1800

tgcctcattt tctcttattt ttgatctatc tagtaattct tttgctgcct gtctcttctc   1860

cattttcctt cttctttttt aagcattttt catattcttc actgtcttct atttggtctt   1920

gattaggtgc atctatctct tcgctctgtc ttccacaaac aaaaattctg ccttcagaca   1980

tttggtgtta gtatttcaca ctcagttctc ccttttttta cataaggatt gagtttcttt   2040

ttatgatgat tttaccttta tagcaatttt gaattttgca ttctgttgct agtattgatt   2100

caggtacacc attaagatac aacattctag aagtctatta ccttaggagt taattaaaca   2160

tgatatttga agaataatga aatgctttat agttgtttga ggcataacaa tgtgtatttg   2220

ttttactgga tcatgttttg aactgactag ggagggtagc acctgcctca gatagtacca   2280

acaattctgt ttcactgggt agtctaaaac tagcttatag tttaacttaa cttgttgtgt   2340

atgtgaattt agggatggaa actttttttc ccctatttat tctttgtttc cttctgggaa   2400

aaaaccccac aaaaatcagc actcctttat ggatacattg gagcttttga aagaattgta   2460

aactctagga aggggaaata tctgtgtctt gatttcttag ttgccttgaa aatcatgtac   2520

tgaactgtaa ccgctaactt gactggatga actagtttgc ttgtgtgtag agagtgtatt   2580

gcttcctcag atttcactgt tttcatctcc ttttccatct tagtctttat tccttaagac   2640

caaaaactgt aatatccttt agaaatgctc tagaagatct gtattgtgta gaatgatcat   2700

gtatttataa atattttaca agtttagatt ataaaatgaa aaagaaggtc atgtgttttg   2760

gggggtattt tgcatgttcg gatttttttt tcccttcacc gaacccttct gattctttca   2820

aactattgcc aggtagttgt tagtgtttct aattggactc ttaatatgaa cttcaagaag   2880

ctgttaccag ttatcggctc tgtcatctga aattttaacc acttaattta aagttacaat   2940

tttagaattt gtttttgttg ttttacctta agaaacacaa taaatcactg tttaaaaaag   3000

atctcaattt atataaagta ctggaaaaaa gctaagtaat ttttagttct atctataatc   3060

tccgtaggat gaattagaaa taaattgtga tgaaaagaaa ttaactgctt atttatgaat   3120

ctaatcattt agaaatgtct gagagtaaca ctgcattctt atagaaacaa agcacaaatt   3180

gcattcaagc tctgaattga ttttttgctt ggagctgttg ttacagtagc tgtaattttg   3240

ctaccagaat gtcttaattt tttaaatttg tttttatttc taagctcttg gcaatgacaa   3300

taattataat tttaacatat cttcactgta gtcaacatgt agagtctgct tccctcatta   3360

ttgcattgct aaggcctttt taaaaagctt atgcttacat aatatactct tttttatgga   3420

cacgttatat gtttccaaat ctgtgtattg tgatttttac atactaatga atataaacag   3480

gtgattttaa aatattactg tgcttctttg gttgaatgag ctggtattga tgtaaaatac   3540

tctgtcattg atggaccact acctgcagct aagcagtgag cagaatctcc gggaaatgac   3600

ttagtctggc cacatgcata gcccatcttc ataatgtcgc agcagaaggt tctttgtggt   3660

taaaagtttt aaagcctatt tctttatagg taaccctctc aggtatattt acctggtaga   3720

aaaacatgta gattgtttct attacttaaa tgttttaatt ggactgtagt ttagaaatta   3780

caggaccagc ttgttacaga ttatacacta ttctgttact tttatttctg aaacttaaaa   3840

acaataaatt ctttttctgt gtttctaggt tagaactttt ttattttatt gcacactgaa   3900

cagatactgt tgcttattga atattgtgta aacccttctt tggctttcct tgcccattgc   3960

aatttgattt aagcctacta gagccattgt atgtgacagc tatattgtat tacaaagtaa   4020

aaatatatga gtgtattgaa aaaaaaaaaa aaaaaaaa                           4058


<210>  2288
<211>  479
<212>  PRT
<213>  Homosapiens

<400>  2288

Met Leu Gln Ile Asn Gln Met Phe Ser Val Gln Leu Ser Leu Gly Glu 
1               5                   10                  15      


Gln Thr Trp Glu Ser Glu Gly Ser Ser Ile Lys Lys Ala Gln Gln Ala 
            20                  25                  30          


Val Ala Asn Lys Ala Leu Thr Glu Ser Thr Leu Pro Lys Pro Val Gln 
        35                  40                  45              


Lys Pro Pro Lys Ser Asn Val Asn Asn Asn Pro Gly Ser Ile Thr Pro 
    50                  55                  60                  


Thr Val Glu Leu Asn Gly Leu Ala Met Lys Arg Gly Glu Pro Ala Ile 
65                  70                  75                  80  


Tyr Arg Pro Leu Asp Pro Lys Pro Phe Pro Asn Tyr Arg Ala Asn Tyr 
                85                  90                  95      


Asn Phe Arg Gly Met Tyr Asn Gln Arg Tyr His Cys Pro Val Pro Lys 
            100                 105                 110         


Ile Phe Tyr Val Gln Leu Thr Val Gly Asn Asn Glu Phe Phe Gly Glu 
        115                 120                 125             


Gly Lys Thr Arg Gln Ala Ala Arg His Asn Ala Ala Met Lys Ala Leu 
    130                 135                 140                 


Gln Ala Leu Gln Asn Glu Pro Ile Pro Glu Arg Ser Pro Gln Asn Gly 
145                 150                 155                 160 


Glu Ser Gly Lys Asp Met Asp Asp Asp Lys Asp Ala Asn Lys Ser Glu 
                165                 170                 175     


Ile Ser Leu Val Phe Glu Ile Ala Leu Lys Arg Asn Met Pro Val Ser 
            180                 185                 190         


Phe Glu Val Ile Lys Glu Ser Gly Pro Pro His Met Lys Ser Phe Val 
        195                 200                 205             


Thr Arg Val Ser Val Gly Glu Phe Ser Ala Glu Gly Glu Gly Asn Ser 
    210                 215                 220                 


Lys Lys Leu Ser Lys Lys Arg Ala Ala Thr Thr Val Leu Gln Glu Leu 
225                 230                 235                 240 


Lys Lys Leu Pro Pro Leu Pro Val Val Glu Lys Pro Lys Leu Phe Phe 
                245                 250                 255     


Lys Lys Arg Pro Lys Thr Ile Val Lys Ala Gly Pro Glu Tyr Gly Gln 
            260                 265                 270         


Gly Met Asn Pro Ile Ser Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys 
        275                 280                 285             


Glu Lys Glu Pro Asp Tyr Val Leu Leu Ser Glu Arg Gly Met Pro Arg 
    290                 295                 300                 


Arg Arg Glu Phe Val Met Gln Val Lys Val Gly Asn Glu Val Ala Thr 
305                 310                 315                 320 


Gly Thr Gly Pro Asn Lys Lys Ile Ala Lys Lys Asn Ala Ala Glu Ala 
                325                 330                 335     


Met Leu Leu Gln Leu Gly Tyr Lys Ala Ser Thr Asn Leu Gln Asp Gln 
            340                 345                 350         


Leu Glu Lys Thr Gly Glu Asn Lys Gly Trp Ser Gly Pro Lys Pro Gly 
        355                 360                 365             


Phe Pro Glu Pro Thr Asn Asn Thr Pro Lys Gly Ile Leu His Leu Ser 
    370                 375                 380                 


Pro Asp Val Tyr Gln Glu Met Glu Ala Ser Arg His Lys Val Ile Ser 
385                 390                 395                 400 


Gly Thr Thr Leu Gly Tyr Leu Ser Pro Lys Asp Met Asn Gln Pro Ser 
                405                 410                 415     


Ser Ser Phe Phe Ser Ile Ser Pro Thr Ser Asn Ser Ser Ala Thr Ile 
            420                 425                 430         


Ala Arg Glu Leu Leu Met Asn Gly Thr Ser Ser Thr Ala Glu Ala Ile 
        435                 440                 445             


Gly Leu Lys Gly Ser Ser Pro Thr Pro Pro Cys Ser Pro Val Gln Pro 
    450                 455                 460                 


Ser Lys Gln Leu Glu Tyr Leu Ala Arg Ile Gln Gly Phe Gln Val 
465                 470                 475                 


<210>  2289
<211>  4057
<212>  DNA
<213>  Homosapiens

<400>  2289
agctcctccc cctgcgtctc tggcctcgcc ggtcttgggg ggatggttcc atcatggcgt     60

caatgcagac cacaggaagg agggtggaag tatggtttcc aaaacgacta cagaaagaac    120

tgttggcttt gcaaaatgac ccacctcctg gaatgacctt aaatgagaag agtgttcaaa    180

attcaattac acagtggatt gtagacatgg aaggtgcacc aggtacctta tatgaagggg    240

aaaaatttca acttctattt aaatttagta gtcgatatcc ttttgactct cctcaggtca    300

tgtttactgg tgaaaatatt cctgttcatc ctcatgttta tagcaatggt catatctgtt    360

tatccattct aacagaagac tggtccccag cgctctcagt ccaatcagtt tgtcttagca    420

ttattagcat gctttccagc tgcaaggaaa agagacgacc accggataat tctttttatg    480

tgcgaacatg taacaagaat ccaaagaaaa caaaatggtg gtatcatgat gatacttgtt    540

gatgccactg ttatcatcct cctagcagaa gatagtccta ctgagaaaat gagcactttg    600

atcattcagt ctttgaactt taacctttga ctggaagtga cctataggca atgaagacta    660

cttcctttta ctgcattttt actcgtgtgc attctgggcg catgttgatc gctggttcag    720

tccaggcaac tgacatgctt ttattagtca tacagtatta atgcaggtgt caggaaatgt    780

caaatataat tccatttttt atttttattt ttttaagctt ttggaaaagc tccaggtcct    840

catgtattgt gcaataacaa tgacttcctt ggcggttttg gtacgttcat tgccggcaat    900

gggcgttgta acaggaaaag ttttcattaa ctcctgccat tcaatgatta atgcatgata    960

gggcctatga aatgaactta ctggttatag tgggaatata aataaagtga gggatccaac   1020

attactttaa aagtcacccc aactgtttat atttggattc tatgcactgt gatcctaagg   1080

ttaacagcat gaattaacat gcgtctttaa aggactgtaa tgaaagatca ttgcatattt   1140

attgaattgt ttatatctac tgtcaagttg ttttgacatg gaagattttc aagtaacatt   1200

ggcagagagg tacagtatgt tatccctatg gtgaaaataa attaatttgt tgtatatagt   1260

tcctcaatct ctgaagtaaa ggtatgagta atatagggta tgaatggttt aatcaaggct   1320

ttattttgga agtaagaaaa atggcagtga tgattaaatt gctgcagtcc ataatttggg   1380

cttgttattt gtacattaaa gattttttcc aagtaagtta cactctgtta acttcctgct   1440

agccatcagc atgagcccta ctgcctaaac actatttcat ttatttatgt ttggaaaccc   1500

cgtaaacatt tttgtttgca atcttgtttc ttttgttata agtcaagttt gaatgttaca   1560

atacttttat tgaaactttt gttaagtttt ttcttgtaaa ttttctttac ttgtgagtat   1620

catcttgtcc tttaatcctg taccctaaaa taagaaatac atttttgaca gaggcttaat   1680

gttttaacaa aagagtgtgg acatttttat tttaaaattt aggcaaaagt cactatcaaa   1740

tggttgctta tttgtctcac acagccatat agtttttcct ggagggtttt gttttgttgt   1800

tgttgaaaag actttgctta cagctagatg aaactttcta tagaaaaaaa aaattgttga   1860

aaggtccagt tctcagtacc atgtgagtta atgatactac aactaagttc tttttaaaaa   1920

gtgattaatg tattttataa attacctttt cacatatgca aaatctgttt ctactacaat   1980

gttattttta ctaatgcctt attgttgcac tctttttgaa atatcctgca gtgaatatat   2040

gaatcaattt gggcttaaaa ctgaaagcca gttggctgaa aggtttgaaa tacgtacccc   2100

agtaaaacca ttcaatcaat aattggtaaa taatatttta aaattgtttt taatctgtat   2160

agatgacatt ttgtagcttt gtacatgttg ttaattaagg gcatataatt ttacactcaa   2220

agtataattg ctgaactcag gggtgggtag acttcaaaaa tatgtctgct atagaaataa   2280

cttgaaaaaa aaaattaaaa ccgtggccag ccaccaaatt gtggacactg tttatatact   2340

gctagttaac aattaccact tttaaaaaat tataaccgtt tttgttctat cttgactaga   2400

taaattctca caatgatctc tgtcagtttt attagttggc ctgtttaacc aagacagaaa   2460

gtctttgaat tactcatagt tttaaactgc ttttaatatg aaaattgcag ctgtaaatta   2520

tgtattttca tattttgcgt aactgctcta cactactgtt tgacttgatc ttcttctggg   2580

ggttagggag aaatctgtct ccatattgct ggttctctta ccaaaatgct tttataaaga   2640

aatgaccggt gacatttatt caccaaagga attaatatac tgagtcaaag attaacaatg   2700

ctatactata gagtaatagg tcatatatag cctcaattga gttttttatg acaatatttt   2760

aacatacctc tctctctaca tataaatacc ataaagtaaa ctaaaatgac acagaggaaa   2820

gtagaggaaa atgaaataat ttcggtacat cttatggttt aaagagtaga aaataagatg   2880

aaatatccta aaatatagga gcacagacat ttaaaattca taatcaggct aacaacactc   2940

tcttgaattt aggaatcatt gaaaactcct tgcacttaga tttaatttat atgttagtta   3000

cattattaaa agtcataagg catttatctg agtcattgct ctacagagag caattaatgg   3060

cttgtaataa taaaaagaat atttctctgt aatgcattgt tgaaagacaa ccagaatatc   3120

aagaaaatgt atataggaat atgctacttg cctcctccct gcatttcctc gtggggcact   3180

atttgcgaca taggcctaca gaattagact ttcatactta gaagataagg tacactcttc   3240

ttcttttatt tatttattta tttattttta ggccattctt ctggtttgcc aaattctatt   3300

aagacagtga tacatttgct tccttattta tgcatgctta gatcatgaac atgatgccct   3360

tctttttttt ttttttcttt ggtcaagtag ggattaatgc cataggttta gagagaagga   3420

ttgttttcag tttttaagag aattttttaa aaatacattt tatggttctc ttaaggaatt   3480

aatattcact tctgaaggac ttacttgtaa tatataattt atcattttag ccagcaggga   3540

aataaatcat ttttaatccc cagaagaaag tgctggaaat agcttctata tagtcagcag   3600

ttcacctgga gaaagatctt aattccttgt tgttttgact aggaatatca atatttggta   3660

taaaataact agaatagttt attacctttt ccctcatgaa attttaaata tatgcaaata   3720

tatatatcat tagattcctg tggtggataa taatttcttc agattctaaa acaggtgtct   3780

agtgactgct taattgtttc caagttgcat caaagatgaa ttggtaaata atggaaatga   3840

gtagtgatat gaaaatggtt atgtaactac atattacttg tttctggtaa tcaagtctta   3900

ttttttaaaa gcctattgtt tttcagaatt gagatattta aaacttgtta taacttcttc   3960

ctaaaaatag aagagaagag gaggtactgt gtgttacaaa aattttttta aataaagaat   4020

tcagtgtcac tagttctaaa aaaaaaaaaa aaaaaca                            4057


<210>  2290
<211>  162
<212>  PRT
<213>  Homosapiens

<400>  2290

Met Ala Ser Met Gln Thr Thr Gly Arg Arg Val Glu Val Trp Phe Pro 
1               5                   10                  15      


Lys Arg Leu Gln Lys Glu Leu Leu Ala Leu Gln Asn Asp Pro Pro Pro 
            20                  25                  30          


Gly Met Thr Leu Asn Glu Lys Ser Val Gln Asn Ser Ile Thr Gln Trp 
        35                  40                  45              


Ile Val Asp Met Glu Gly Ala Pro Gly Thr Leu Tyr Glu Gly Glu Lys 
    50                  55                  60                  


Phe Gln Leu Leu Phe Lys Phe Ser Ser Arg Tyr Pro Phe Asp Ser Pro 
65                  70                  75                  80  


Gln Val Met Phe Thr Gly Glu Asn Ile Pro Val His Pro His Val Tyr 
                85                  90                  95      


Ser Asn Gly His Ile Cys Leu Ser Ile Leu Thr Glu Asp Trp Ser Pro 
            100                 105                 110         


Ala Leu Ser Val Gln Ser Val Cys Leu Ser Ile Ile Ser Met Leu Ser 
        115                 120                 125             


Ser Cys Lys Glu Lys Arg Arg Pro Pro Asp Asn Ser Phe Tyr Val Arg 
    130                 135                 140                 


Thr Cys Asn Lys Asn Pro Lys Lys Thr Lys Trp Trp Tyr His Asp Asp 
145                 150                 155                 160 


Thr Cys 
        


<210>  2291
<211>  3921
<212>  DNA
<213>  Homosapiens

<400>  2291
agctcctccc cctgcgtctc tggcctcgcc ggtcttgggg ggatggttcc atcatggcgt     60

caatgcagaa acgactacag aaagaactgt tggctttgca aaatgaccca cctcctggaa    120

tgaccttaaa tgagaagagt gttcaaaatt caattacaca gtcatgttta ctggtgaaaa    180

tattcctgtt catcctcatg tttatagcaa tggtcatatc tgtttatcca ttctaacaga    240

agactggtcc ccagcgctct cagtccaatc agtttgtctt agcattatta gcatgctttc    300

cagctgcaag gaaaagagac gaccaccgga taattctttt tatgtgcgaa catgtaacaa    360

gaatccaaag aaaacaaaat ggtggtatca tgatgatact tgttgatgcc actgttatca    420

tcctcctagc agaagatagt cctactgaga aaatgagcac tttgatcatt cagtctttga    480

actttaacct ttgactggaa gtgacctata ggcaatgaag actacttcct tttactgcat    540

ttttactcgt gtgcattctg ggcgcatgtt gatcgctggt tcagtccagg caactgacat    600

gcttttatta gtcatacagt attaatgcag gtgtcaggaa atgtcaaata taattccatt    660

ttttattttt atttttttaa gcttttggaa aagctccagg tcctcatgta ttgtgcaata    720

acaatgactt ccttggcggt tttggtacgt tcattgccgg caatgggcgt tgtaacagga    780

aaagttttca ttaactcctg ccattcaatg attaatgcat gatagggcct atgaaatgaa    840

cttactggtt atagtgggaa tataaataaa gtgagggatc caacattact ttaaaagtca    900

ccccaactgt ttatatttgg attctatgca ctgtgatcct aaggttaaca gcatgaatta    960

acatgcgtct ttaaaggact gtaatgaaag atcattgcat atttattgaa ttgtttatat   1020

ctactgtcaa gttgttttga catggaagat tttcaagtaa cattggcaga gaggtacagt   1080

atgttatccc tatggtgaaa ataaattaat ttgttgtata tagttcctca atctctgaag   1140

taaaggtatg agtaatatag ggtatgaatg gtttaatcaa ggctttattt tggaagtaag   1200

aaaaatggca gtgatgatta aattgctgca gtccataatt tgggcttgtt atttgtacat   1260

taaagatttt ttccaagtaa gttacactct gttaacttcc tgctagccat cagcatgagc   1320

cctactgcct aaacactatt tcatttattt atgtttggaa accccgtaaa catttttgtt   1380

tgcaatcttg tttcttttgt tataagtcaa gtttgaatgt tacaatactt ttattgaaac   1440

ttttgttaag ttttttcttg taaattttct ttacttgtga gtatcatctt gtcctttaat   1500

cctgtaccct aaaataagaa atacattttt gacagaggct taatgtttta acaaaagagt   1560

gtggacattt ttattttaaa atttaggcaa aagtcactat caaatggttg cttatttgtc   1620

tcacacagcc atatagtttt tcctggaggg ttttgttttg ttgttgttga aaagactttg   1680

cttacagcta gatgaaactt tctatagaaa aaaaaaattg ttgaaaggtc cagttctcag   1740

taccatgtga gttaatgata ctacaactaa gttcttttta aaaagtgatt aatgtatttt   1800

ataaattacc ttttcacata tgcaaaatct gtttctacta caatgttatt tttactaatg   1860

ccttattgtt gcactctttt tgaaatatcc tgcagtgaat atatgaatca atttgggctt   1920

aaaactgaaa gccagttggc tgaaaggttt gaaatacgta ccccagtaaa accattcaat   1980

caataattgg taaataatat tttaaaattg tttttaatct gtatagatga cattttgtag   2040

ctttgtacat gttgttaatt aagggcatat aattttacac tcaaagtata attgctgaac   2100

tcaggggtgg gtagacttca aaaatatgtc tgctatagaa ataacttgaa aaaaaaaatt   2160

aaaaccgtgg ccagccacca aattgtggac actgtttata tactgctagt taacaattac   2220

cacttttaaa aaattataac cgtttttgtt ctatcttgac tagataaatt ctcacaatga   2280

tctctgtcag ttttattagt tggcctgttt aaccaagaca gaaagtcttt gaattactca   2340

tagttttaaa ctgcttttaa tatgaaaatt gcagctgtaa attatgtatt ttcatatttt   2400

gcgtaactgc tctacactac tgtttgactt gatcttcttc tgggggttag ggagaaatct   2460

gtctccatat tgctggttct cttaccaaaa tgcttttata aagaaatgac cggtgacatt   2520

tattcaccaa aggaattaat atactgagtc aaagattaac aatgctatac tatagagtaa   2580

taggtcatat atagcctcaa ttgagttttt tatgacaata ttttaacata cctctctctc   2640

tacatataaa taccataaag taaactaaaa tgacacagag gaaagtagag gaaaatgaaa   2700

taatttcggt acatcttatg gtttaaagag tagaaaataa gatgaaatat cctaaaatat   2760

aggagcacag acatttaaaa ttcataatca ggctaacaac actctcttga atttaggaat   2820

cattgaaaac tccttgcact tagatttaat ttatatgtta gttacattat taaaagtcat   2880

aaggcattta tctgagtcat tgctctacag agagcaatta atggcttgta ataataaaaa   2940

gaatatttct ctgtaatgca ttgttgaaag acaaccagaa tatcaagaaa atgtatatag   3000

gaatatgcta cttgcctcct ccctgcattt cctcgtgggg cactatttgc gacataggcc   3060

tacagaatta gactttcata cttagaagat aaggtacact cttcttcttt tatttattta   3120

tttatttatt tttaggccat tcttctggtt tgccaaattc tattaagaca gtgatacatt   3180

tgcttcctta tttatgcatg cttagatcat gaacatgatg cccttctttt tttttttttt   3240

ctttggtcaa gtagggatta atgccatagg tttagagaga aggattgttt tcagttttta   3300

agagaatttt ttaaaaatac attttatggt tctcttaagg aattaatatt cacttctgaa   3360

ggacttactt gtaatatata atttatcatt ttagccagca gggaaataaa tcatttttaa   3420

tccccagaag aaagtgctgg aaatagcttc tatatagtca gcagttcacc tggagaaaga   3480

tcttaattcc ttgttgtttt gactaggaat atcaatattt ggtataaaat aactagaata   3540

gtttattacc ttttccctca tgaaatttta aatatatgca aatatatata tcattagatt   3600

cctgtggtgg ataataattt cttcagattc taaaacaggt gtctagtgac tgcttaattg   3660

tttccaagtt gcatcaaaga tgaattggta aataatggaa atgagtagtg atatgaaaat   3720

ggttatgtaa ctacatatta cttgtttctg gtaatcaagt cttatttttt aaaagcctat   3780

tgtttttcag aattgagata tttaaaactt gttataactt cttcctaaaa atagaagaga   3840

agaggaggta ctgtgtgtta caaaaatttt tttaaataaa gaattcagtg tcactagttc   3900

taaaaaaaaa aaaaaaaaac a                                             3921


<210>  2292
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  2292

Met Ala Ser Met Gln Lys Arg Leu Gln Lys Glu Leu Leu Ala Leu Gln 
1               5                   10                  15      


Asn Asp Pro Pro Pro Gly Met Thr Leu Asn Glu Lys Ser Val Gln Asn 
            20                  25                  30          


Ser Ile Thr Gln Ser Cys Leu Leu Val Lys Ile Phe Leu Phe Ile Leu 
        35                  40                  45              


Met Phe Ile Ala Met Val Ile Ser Val Tyr Pro Phe 
    50                  55                  60  


<210>  2293
<211>  4024
<212>  DNA
<213>  Homosapiens

<400>  2293
agctcctccc cctgcgtctc tggcctcgcc ggtcttgggg ggatggttcc atcatggcgt     60

caatgcagaa acgactacag aaagaactgt tggctttgca aaatgaccca cctcctggaa    120

tgaccttaag tgagaagagt gttcaaaatt caattacaca gtggattgta gacatggaag    180

gtgcaccagg taccttatat gaaggggaaa aatttcaact tctatttaaa tttagtagtc    240

gatatccttt tgactctcct caggtcatgt ttactggtga aaatattcct gttcatcctc    300

atgtttatag caatggtcat atctgtttat ccattctaac agaagactgg tccccagcgc    360

tctcagtcca atcagtttgt cttagcatta ttagcatgct ttccagctgc aaggaaaaga    420

gacgaccacc ggataattct ttttatgtgc gaacatgtaa caagaatcca aagaaaacaa    480

aatggtggta tcatgatgat acttgttgat gccactgtta tcatcctcct agcagaagat    540

agtcctactg agaaaatgag cactttgatc attcagtctt tgaactttaa cctttgactg    600

gaagtgacct ataggcaatg aagactactt ccttttactg catttttact cgtgtgcatt    660

ctgggcgcat gttgatcgct ggttcagtcc aggcaactga catgctttta ttagtcatac    720

agtattaatg caggtgtcag gaaatgtcaa atataattcc attttttatt tttatttttt    780

taagcttttg gaaaagctcc aggtcctcat gtattgtgca ataacaatga cttccttggc    840

ggttttggta cgttcattgc cggcaatggg cgttgtaaca ggaaaagttt tcattaactc    900

ctgccattca atgattaatg catgataggg cctatgaaat gaacttactg gttatagtgg    960

gaatataaat aaagtgaggg atccaacatt actttaaaag tcaccccaac tgtttatatt   1020

tggattctat gcactgtgat cctaaggtta acagcatgaa ttaacatgcg tctttaaagg   1080

actgtaatga aagatcattg catatttatt gaattgttta tatctactgt caagttgttt   1140

tgacatggaa gattttcaag taacattggc agagaggtac agtatgttat ccctatggtg   1200

aaaataaatt aatttgttgt atatagttcc tcaatctctg aagtaaaggt atgagtaata   1260

tagggtatga atggtttaat caaggcttta ttttggaagt aagaaaaatg gcagtgatga   1320

ttaaattgct gcagtccata atttgggctt gttatttgta cattaaagat tttttccaag   1380

taagttacac tctgttaact tcctgctagc catcagcatg agccctactg cctaaacact   1440

atttcattta tttatgtttg gaaaccccgt aaacattttt gtttgcaatc ttgtttcttt   1500

tgttataagt caagtttgaa tgttacaata cttttattga aacttttgtt aagttttttc   1560

ttgtaaattt tctttacttg tgagtatcat cttgtccttt aatcctgtac cctaaaataa   1620

gaaatacatt tttgacagag gcttaatgtt ttaacaaaag agtgtggaca tttttatttt   1680

aaaatttagg caaaagtcac tatcaaatgg ttgcttattt gtctcacaca gccatatagt   1740

ttttcctgga gggttttgtt ttgttgttgt tgaaaagact ttgcttacag ctagatgaaa   1800

ctttctatag aaaaaaaaaa ttgttgaaag gtccagttct cagtaccatg tgagttaatg   1860

atactacaac taagttcttt ttaaaaagtg attaatgtat tttataaatt accttttcac   1920

atatgcaaaa tctgtttcta ctacaatgtt atttttacta atgccttatt gttgcactct   1980

ttttgaaata tcctgcagtg aatatatgaa tcaatttggg cttaaaactg aaagccagtt   2040

ggctgaaagg tttgaaatac gtaccccagt aaaaccattc aatcaataat tggtaaataa   2100

tattttaaaa ttgtttttaa tctgtataga tgacattttg tagctttgta catgttgtta   2160

attaagggca tataatttta cactcaaagt ataattgctg aactcagggg tgggtagact   2220

tcaaaaatat gtctgctata gaaataactt gaaaaaaaaa attaaaaccg tggccagcca   2280

ccaaattgtg gacactgttt atatactgct agttaacaat taccactttt aaaaaattat   2340

aaccgttttt gttctatctt gactagataa attctcacaa tgatctctgt cagttttatt   2400

agttggcctg tttaaccaag acagaaagtc tttgaattac tcatagtttt aaactgcttt   2460

taatatgaaa attgcagctg taaattatgt attttcatat tttgcgtaac tgctctacac   2520

tactgtttga cttgatcttc ttctgggggt tagggagaaa tctgtctcca tattgctggt   2580

tctcttacca aaatgctttt ataaagaaat gaccggtgac atttattcac caaaggaatt   2640

aatatactga gtcaaagatt aacaatgcta tactatagag taataggtca tatatagcct   2700

caattgagtt ttttatgaca atattttaac atacctctct ctctacatat aaataccata   2760

aagtaaacta aaatgacaca gaggaaagta gaggaaaatg aaataatttc ggtacatctt   2820

atggtttaaa gagtagaaaa taagatgaaa tatcctaaaa tataggagca cagacattta   2880

aaattcataa tcaggctaac aacactctct tgaatttagg aatcattgaa aactccttgc   2940

acttagattt aatttatatg ttagttacat tattaaaagt cataaggcat ttatctgagt   3000

cattgctcta cagagagcaa ttaatggctt gtaataataa aaagaatatt tctctgtaat   3060

gcattgttga aagacaacca gaatatcaag aaaatgtata taggaatatg ctacttgcct   3120

cctccctgca tttcctcgtg gggcactatt tgcgacatag gcctacagaa ttagactttc   3180

atacttagaa gataaggtac actcttcttc ttttatttat ttatttattt atttttaggc   3240

cattcttctg gtttgccaaa ttctattaag acagtgatac atttgcttcc ttatttatgc   3300

atgcttagat catgaacatg atgcccttct tttttttttt tttctttggt caagtaggga   3360

ttaatgccat aggtttagag agaaggattg ttttcagttt ttaagagaat tttttaaaaa   3420

tacattttat ggttctctta aggaattaat attcacttct gaaggactta cttgtaatat   3480

ataatttatc attttagcca gcagggaaat aaatcatttt taatccccag aagaaagtgc   3540

tggaaatagc ttctatatag tcagcagttc acctggagaa agatcttaat tccttgttgt   3600

tttgactagg aatatcaata tttggtataa aataactaga atagtttatt accttttccc   3660

tcatgaaatt ttaaatatat gcaaatatat atatcattag attcctgtgg tggataataa   3720

tttcttcaga ttctaaaaca ggtgtctagt gactgcttaa ttgtttccaa gttgcatcaa   3780

agatgaattg gtaaataatg gaaatgagta gtgatatgaa aatggttatg taactacata   3840

ttacttgttt ctggtaatca agtcttattt tttaaaagcc tattgttttt cagaattgag   3900

atatttaaaa cttgttataa cttcttccta aaaatagaag agaagaggag gtactgtgtg   3960

ttacaaaaat ttttttaaat aaagaattca gtgtcactag ttctaaaaaa aaaaaaaaaa   4020

aaca                                                                4024


<210>  2294
<211>  151
<212>  PRT
<213>  Homosapiens

<400>  2294

Met Ala Ser Met Gln Lys Arg Leu Gln Lys Glu Leu Leu Ala Leu Gln 
1               5                   10                  15      


Asn Asp Pro Pro Pro Gly Met Thr Leu Ser Glu Lys Ser Val Gln Asn 
            20                  25                  30          


Ser Ile Thr Gln Trp Ile Val Asp Met Glu Gly Ala Pro Gly Thr Leu 
        35                  40                  45              


Tyr Glu Gly Glu Lys Phe Gln Leu Leu Phe Lys Phe Ser Ser Arg Tyr 
    50                  55                  60                  


Pro Phe Asp Ser Pro Gln Val Met Phe Thr Gly Glu Asn Ile Pro Val 
65                  70                  75                  80  


His Pro His Val Tyr Ser Asn Gly His Ile Cys Leu Ser Ile Leu Thr 
                85                  90                  95      


Glu Asp Trp Ser Pro Ala Leu Ser Val Gln Ser Val Cys Leu Ser Ile 
            100                 105                 110         


Ile Ser Met Leu Ser Ser Cys Lys Glu Lys Arg Arg Pro Pro Asp Asn 
        115                 120                 125             


Ser Phe Tyr Val Arg Thr Cys Asn Lys Asn Pro Lys Lys Thr Lys Trp 
    130                 135                 140                 


Trp Tyr His Asp Asp Thr Cys 
145                 150     


<210>  2295
<211>  668
<212>  DNA
<213>  Homosapiens

<400>  2295
cggggacccg gctgcggtgg ctgcgggact gacgagaaac tactaaagtt cctggggaag     60

caaagtagaa tttcataaga acaaaatgga tggagaggag aaaacctatg gtggctgtga    120

aggacctgat gccatgtatg tcaaattgat atcatctgat ggccatgaat ttattgtaaa    180

aagagaacat gcattaacat caggcacgat aaaagccatg ttgagtggcc caggtcagtt    240

tgctgagaac gaaaccaatg aggtcaattt tagagagata ccttcacatg tgctatcgaa    300

agtatgcatg tattttacgt acaaggttcg ctacactaac agctccaccg agattcctga    360

attcccaatt gcacctgaaa ttgcactgga actgctgatg gctgcgaact tcttagattg    420

ttaaataaaa taaattataa taaactgtta actcttttca gtatttaata cctgtagttc    480

agttagtaac tttttcatat atagcatgtt gcctgtatgc agttgaacta tataaagttc    540

attgcaaagc agattatctt gtttttttgc atagcaatca aagttgaaat ttgtttgcta    600

catcaacaaa ttaaggacat tttcacaaac tgagaaataa acaaatatgc caattaaaaa    660

aaaaaaaa                                                             668


<210>  2296
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  2296

Met Asp Gly Glu Glu Lys Thr Tyr Gly Gly Cys Glu Gly Pro Asp Ala 
1               5                   10                  15      


Met Tyr Val Lys Leu Ile Ser Ser Asp Gly His Glu Phe Ile Val Lys 
            20                  25                  30          


Arg Glu His Ala Leu Thr Ser Gly Thr Ile Lys Ala Met Leu Ser Gly 
        35                  40                  45              


Pro Gly Gln Phe Ala Glu Asn Glu Thr Asn Glu Val Asn Phe Arg Glu 
    50                  55                  60                  


Ile Pro Ser His Val Leu Ser Lys Val Cys Met Tyr Phe Thr Tyr Lys 
65                  70                  75                  80  


Val Arg Tyr Thr Asn Ser Ser Thr Glu Ile Pro Glu Phe Pro Ile Ala 
                85                  90                  95      


Pro Glu Ile Ala Leu Glu Leu Leu Met Ala Ala Asn Phe Leu Asp Cys 
            100                 105                 110         


<210>  2297
<211>  2044
<212>  DNA
<213>  Homosapiens

<400>  2297
acttgtgcgg cagtcgggtg ggaagccgtg tctcgcagtc gtggactcgt gcagctgggg     60

cgtccgcagc cgctcgtcac ccgcgtgatg ctgtttctgg cgttgggcag cccgtgggcg    120

gtcgaactgc ctctctgcgg aaggaggact gcattgtgtg cggccgccgc gctccgaggt    180

ccccgggcct ctgtctcccg ggcgtcctcc agcagcgggc cttcggggcc ggtagccggc    240

tggagtacgg ggccttcggg agccgcgcgc cttctccggc gtccgggtcg agcgcagatc    300

cctgtttatt gggaaggata tgttcgattc ttaaatacgc catctgacaa atcagaagat    360

ggaaggctaa tttatactgg caatatggcc cgagcagtgt ttggtaagta attggaggtg    420

tgaaatgttt ctcttattct acgagtctga ttggccttac atttctgcca tacattttta    480

cacaaaataa tgctatttct gaaagtgtgc ctctgcctat tcaaatcata ttctatggca    540

tcatgggaag ctttacggtg atcaccccag tgctgcttca ctttattaca aaaggctatg    600

tcattcgatt gtaccatgag gccacaacag acacttataa agccattacc tacaatgcta    660

tgcttgcaga aacgagtaca gtgtttcacc agaatgatgt gaagattcca gatgctaaac    720

atgtatttac cacattttat gctaaaacaa aatcactgtt agttaatcca gtgctctttc    780

caaaccgtga agactatatc catctaatgg gttatgacaa agaagaattt attttgtata    840

tggaagaaac cagtgaagag aaacggcata aagatgacaa atgagcctat ttgttagtgt    900

tcgtgctcaa atgtgattta cgttttaatg tataataata aaattgcctt ttgcattccg    960

ttagtgactg attgttaaaa ataatttgaa attatcaaag cttttaattt ccagagaatg   1020

atgtttgttt ataataaaac aagctatgtt tgaaaaccaa aatgtagtat ctaccattcg   1080

tgttttagaa aggtatgtga ataaatatgt tcatgctagt ataagagttc tgtgttactg   1140

tggttgactc taaactgggg atctgatgtc agtagcaaat gggagagttg ctttattctt   1200

tgtgtatgga tttttctaag tgtataaata ttttccgaca ttaaaagaca ttttctcttt   1260

gaggaagaca cagtcatagg tggtgcggag ctgtggtcca cctgctcctg ctcctgactc   1320

actgctcttt gctgttgcct gaggaccaag tctgtcagga agctggctag gaagccttgc   1380

agcagccatg gcttttaaac ataccagaaa aacacccgtg gagtcagagg tggcaattca   1440

ccgaattcat atcactctaa cgagttgcaa cgtaaaatcc ctggataagg tgtgtgctga   1500

cttgatctga ggagcaaagg aaaagaatca gtgaaaggac cagtttgaat gcctaccaag   1560

actttgagaa tcactacaag aaaaacttac ggtgaaggtt ctaaggcatg ggatcgtttc   1620

cagatgagaa tccacaagcg actcattgac ttgcgcagtc ctcagatagt taagcagatt   1680

acttccatca gtattgagcc aggagttgag atggaagtca ccattgcaaa tgcttaagtc   1740

aactgttttc ataaattgat taccagttgt taaaaaattt tcaaaaaacc gcaaaatttc   1800

aagaaattca caaattatgg gagcagtttt aagtcttctt tggttcagaa cacaggtttt   1860

tgcctaaccc ctggcatgat tgcccataag aacatacatg tacagttgaa ctggtggtta   1920

gctatacggg aaatggtaag tagtgttgtc ttcagtatct taatttgttt ctgcaactgt   1980

gcactcctcc cttggtggca ccctatgggt gtaggaaaac cactgttatt aaacaggtga   2040

aaaa                                                                2044


<210>  2298
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  2298

Met Leu Phe Leu Ala Leu Gly Ser Pro Trp Ala Val Glu Leu Pro Leu 
1               5                   10                  15      


Cys Gly Arg Arg Thr Ala Leu Cys Ala Ala Ala Ala Leu Arg Gly Pro 
            20                  25                  30          


Arg Ala Ser Val Ser Arg Ala Ser Ser Ser Ser Gly Pro Ser Gly Pro 
        35                  40                  45              


Val Ala Gly Trp Ser Thr Gly Pro Ser Gly Ala Ala Arg Leu Leu Arg 
    50                  55                  60                  


Arg Pro Gly Arg Ala Gln Ile Pro Val Tyr Trp Glu Gly Tyr Val Arg 
65                  70                  75                  80  


Phe Leu Asn Thr Pro Ser Asp Lys Ser Glu Asp Gly Arg Leu Ile Tyr 
                85                  90                  95      


Thr Gly Asn Met Ala Arg Ala Val Phe Gly Lys 
            100                 105         


<210>  2299
<211>  2030
<212>  DNA
<213>  Homosapiens

<400>  2299
acttgtgcgg cagtcgggtg ggaagccgtg tctcgcagtc gtggactcgt gcagctgggg     60

cgtccgcagc cgctcgtcac ccgcgtgatg ctgtttctgg cgttgggcag cccgtgggcg    120

gtcgaactgc ctctctgcgg aaggaggact gcattgtgtg cggccgccgc gctccgaggt    180

ccccgggcct ctgtctcccg ggcgtcctcc agcagcgggc cttcggggcc ggtagccggc    240

tggagtacgg ggccttcggg agccgcgcgc cttctccggc gtccgggtcg agcgcagatc    300

cctgtttatt gggaaggata tgttcgattc ttaaatacgc catctgacaa atcagaagat    360

ggaaggctaa tttatactgg caatatggcc cgagcagtgt ttggtgtgaa atgtttctct    420

tattctacga gtctgattgg ccttacattt ctgccataca tttttacaca aaataatgct    480

atttctgaaa gtgtgcctct gcctattcaa atcatattct atggcatcat gggaagcttt    540

acggtgatca ccccagtgct gcttcacttt attacaaaag gctatgtcat tcgattgtac    600

catgaggcca caacagacac ttataaagcc attacctaca atgctatgct tgcagaaacg    660

agtacagtgt ttcaccagaa tgatgtgaag attccagatg ctaaacatgt atttaccaca    720

ttttatgcta aaacaaaatc actgttagtt aatccagtgc tctttccaaa ccgtgaagac    780

tatatccatc taatgggtta tgacaaagaa gaatttattt tgtatatgga agaaaccagt    840

gaagagaaac ggcataaaga tgacaaatga gcctatttgt tagtgttcgt gctcaaatgt    900

gatttacgtt ttaatgtata ataataaaat tgccttttgc attccgttag tgactgattg    960

ttaaaaataa tttgaaatta tcaaagcttt taatttccag agaatgatgt ttgtttataa   1020

taaaacaagc tatgtttgaa aaccaaaatg tagtatctac cattcgtgtt ttagaaaggt   1080

atgtgaataa atatgttcat gctagtataa gagttctgtg ttactgtggt tgactctaaa   1140

ctggggatct gatgtcagta gcaaatggga gagttgcttt attctttgtg tatggatttt   1200

tctaagtgta taaatatttt ccgacattaa aagacatttt ctctttgagg aagacacagt   1260

cataggtggt gcggagctgt ggtccacctg ctcctgctcc tgactcactg ctctttgctg   1320

ttgcctgagg accaagtctg tcaggaagct ggctaggaag ccttgcagca gccatggctt   1380

ttaaacatac cagaaaaaca cccgtggagt cagaggtggc aattcaccga attcatatca   1440

ctctaacgag ttgcaacgta aaatccctgg ataaggtgtg tgctgacttg atctgaggag   1500

caaaggaaaa gaatcagtga aaggaccagt ttgaatgcct accaagactt tgagaatcac   1560

tacaagaaaa acttacggtg aaggttctaa ggcatgggat cgtttccaga tgagaatcca   1620

caagcgactc attgacttgc gcagtcctca gatagttaag cagattactt ccatcagtat   1680

tgagccagga gttgagatgg aagtcaccat tgcaaatgct taagtcaact gttttcataa   1740

attgattacc agttgttaaa aaattttcaa aaaaccgcaa aatttcaaga aattcacaaa   1800

ttatgggagc agttttaagt cttctttggt tcagaacaca ggtttttgcc taacccctgg   1860

catgattgcc cataagaaca tacatgtaca gttgaactgg tggttagcta tacgggaaat   1920

ggtaagtagt gttgtcttca gtatcttaat ttgtttctgc aactgtgcac tcctcccttg   1980

gtggcaccct atgggtgtag gaaaaccact gttattaaac aggtgaaaaa              2030


<210>  2300
<211>  260
<212>  PRT
<213>  Homosapiens

<400>  2300

Met Leu Phe Leu Ala Leu Gly Ser Pro Trp Ala Val Glu Leu Pro Leu 
1               5                   10                  15      


Cys Gly Arg Arg Thr Ala Leu Cys Ala Ala Ala Ala Leu Arg Gly Pro 
            20                  25                  30          


Arg Ala Ser Val Ser Arg Ala Ser Ser Ser Ser Gly Pro Ser Gly Pro 
        35                  40                  45              


Val Ala Gly Trp Ser Thr Gly Pro Ser Gly Ala Ala Arg Leu Leu Arg 
    50                  55                  60                  


Arg Pro Gly Arg Ala Gln Ile Pro Val Tyr Trp Glu Gly Tyr Val Arg 
65                  70                  75                  80  


Phe Leu Asn Thr Pro Ser Asp Lys Ser Glu Asp Gly Arg Leu Ile Tyr 
                85                  90                  95      


Thr Gly Asn Met Ala Arg Ala Val Phe Gly Val Lys Cys Phe Ser Tyr 
            100                 105                 110         


Ser Thr Ser Leu Ile Gly Leu Thr Phe Leu Pro Tyr Ile Phe Thr Gln 
        115                 120                 125             


Asn Asn Ala Ile Ser Glu Ser Val Pro Leu Pro Ile Gln Ile Ile Phe 
    130                 135                 140                 


Tyr Gly Ile Met Gly Ser Phe Thr Val Ile Thr Pro Val Leu Leu His 
145                 150                 155                 160 


Phe Ile Thr Lys Gly Tyr Val Ile Arg Leu Tyr His Glu Ala Thr Thr 
                165                 170                 175     


Asp Thr Tyr Lys Ala Ile Thr Tyr Asn Ala Met Leu Ala Glu Thr Ser 
            180                 185                 190         


Thr Val Phe His Gln Asn Asp Val Lys Ile Pro Asp Ala Lys His Val 
        195                 200                 205             


Phe Thr Thr Phe Tyr Ala Lys Thr Lys Ser Leu Leu Val Asn Pro Val 
    210                 215                 220                 


Leu Phe Pro Asn Arg Glu Asp Tyr Ile His Leu Met Gly Tyr Asp Lys 
225                 230                 235                 240 


Glu Glu Phe Ile Leu Tyr Met Glu Glu Thr Ser Glu Glu Lys Arg His 
                245                 250                 255     


Lys Asp Asp Lys 
            260 


<210>  2301
<211>  587
<212>  DNA
<213>  Homosapiens

<400>  2301
taaatctttt ctgcttactg aaaaggaaga gtctgatgat tagttactga tcctctttgc     60

atttgtaaag ctttggagat attgaatcat gttaccattt ctgttttttt ccaccctgtt    120

ttcttccata tttactgaag ctcagaagca gtattgggtc tgcaactcat ccgatgcaag    180

tatttcatac acctactgtg ataaaatgca atacccaatt tcaattaatg ttaacccctg    240

tatagaattg aaaggatcca aaggattatt gcacattttc tacattccaa ggagagattt    300

aaagcaatta tatttcaatc tctatataac tgtcaacacc atgaatcttc caaagcgcaa    360

agaagttatt tgccgaggat ctgatgacga ttactctttt tgcagagctc tgaagggaga    420

gactgtgaat acaacaatat cattctcctt caagggaata aaattttcta agggaaaata    480

caaatgtgtt gttgaagcta tttctgggag cccagaagaa atgctctttt gcttggagtt    540

tgtcatccta caccaaccta attcaaatta gaataaattg agtattt                  587


<210>  2302
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  2302

Met Leu Pro Phe Leu Phe Phe Ser Thr Leu Phe Ser Ser Ile Phe Thr 
1               5                   10                  15      


Glu Ala Gln Lys Gln Tyr Trp Val Cys Asn Ser Ser Asp Ala Ser Ile 
            20                  25                  30          


Ser Tyr Thr Tyr Cys Asp Lys Met Gln Tyr Pro Ile Ser Ile Asn Val 
        35                  40                  45              


Asn Pro Cys Ile Glu Leu Lys Gly Ser Lys Gly Leu Leu His Ile Phe 
    50                  55                  60                  


Tyr Ile Pro Arg Arg Asp Leu Lys Gln Leu Tyr Phe Asn Leu Tyr Ile 
65                  70                  75                  80  


Thr Val Asn Thr Met Asn Leu Pro Lys Arg Lys Glu Val Ile Cys Arg 
                85                  90                  95      


Gly Ser Asp Asp Asp Tyr Ser Phe Cys Arg Ala Leu Lys Gly Glu Thr 
            100                 105                 110         


Val Asn Thr Thr Ile Ser Phe Ser Phe Lys Gly Ile Lys Phe Ser Lys 
        115                 120                 125             


Gly Lys Tyr Lys Cys Val Val Glu Ala Ile Ser Gly Ser Pro Glu Glu 
    130                 135                 140                 


Met Leu Phe Cys Leu Glu Phe Val Ile Leu His Gln Pro Asn Ser Asn 
145                 150                 155                 160 


<210>  2303
<211>  2588
<212>  DNA
<213>  Homosapiens

<400>  2303
gagctcgggc ggccggagct ggtcgctgcg cgcgccgggg ggagggccgg ggctgcgaga     60

gaggaagctc tttcgcggcg ctacggcgtt ggcaccagtc tctagaaaag aagtcagctc    120

tggttcggag aagcagcggc tggcgtgggc catccgggga atgggcgccc tcgtgaccta    180

gtgttgcggg gcaaaaaggg tcttgccggc ctcgctcgtg caggggcgta tctgggcgcc    240

tgagcgcggc gtgggagcct tgggagccgc cgcagcaggg ggcacacccg gaaccggcct    300

gagcgcccgg gaccatgaac ggggaggcca tctgcagcgc cctgcccacc attccctacc    360

acaaactcgc cgacctgcgc tacctgagcc gcggcgcctc tggcactgtg tcgtccgccc    420

gccacgcaga ctggcgcgtc caggtggccg tgaagcacct gcacatccac actccgctgc    480

tcgacagtga aagaaaggat gtcttaagag aagctgaaat tttacacaaa gctagattta    540

gttacattct tccaattttg ggaatttgca atgagcctga atttttggga atagttactg    600

aatacatgcc aaatggatca ttaaatgaac tcctacatag gaaaactgaa tatcctgatg    660

ttgcttggcc attgagattt cgcatcctgc atgaaattgc ccttggtgta aattacctgc    720

acaatatgac tcctccttta cttcatcatg acttgaagac tcagaatatc ttattggaca    780

atgaatttca tgttaagatt gcagattttg gtttatcaaa gtggcgcatg atgtccctct    840

cacagtcacg aagtagcaaa tctgcaccag aaggagggac aattatctat atgccacctg    900

aaaactatga acctggacaa aaatcaaggg ccagtatcaa gcacgatata tatagctatg    960

cagttatcac atgggaagtg ttatccagaa aacagccttt tgaagatgtc accaatcctt   1020

tgcagataat gtatagtgtg tcacaaggac atcgacctgt tattaatgaa gaaagtttgc   1080

catatgatat acctcaccga gcacgtatga tctctctaat agaaagtgga tgggcacaaa   1140

atccagatga aagaccatct ttcttaaaat gtttaataga acttgaacca gttttgagaa   1200

catttgaaga gataactttt cttgaagctg ttattcagct aaagaaaaca aagttacaga   1260

gtgtttcaag tgccattcac ctatgtgaca agaagaaaat ggaattatct ctgaacatac   1320

ctgtaaatca tggtccacaa gaggaatcat gtggatcctc tcagctccat gaaaatagtg   1380

gttctcctga aacttcaagg tccctgccag ctcctcaaga caatgatttt ttatctagaa   1440

aagctcaaga ctgttatttt atgaagctgc atcactgtcc tggaaatcac agttgggata   1500

gcaccatttc tggatctcaa agggctgcat tctgtgatca caagaccact ccatgctctt   1560

cagcaataat aaatccactc tcaactgcag gaaactcaga acgtctgcag cctggtatag   1620

cccagcagtg gatccagagc aaaagggaag acattgtgaa ccaaatgaca gaagcctgcc   1680

ttaaccagtc gctagatgcc cttctgtcca gggacttgat catgaaagag gactatgaac   1740

ttgttagtac caagcctaca aggacctcaa aagtcagaca attactagac actactgaca   1800

tccaaggaga agaatttgcc aaagttatag tacaaaaatt gaaagataac aaacaaatgg   1860

gtcttcagcc ttacccggaa atacttgtgg tttctagatc accatcttta aatttacttc   1920

aaaataaaag catgtaagtg actgtttttc aagaagaaat gtgtttcata aaaggatatt   1980

tatatctctg ttgctttgac tttttttata taaaatccgt gagtattaaa gctttattga   2040

aggttctttg ggtaaatatt agtctccctc catgacactg cagtattttt tttaattaat   2100

acaagtaaaa agtttgaatt ttgctacata gttcaatttt tatgtctctt ttgttaacag   2160

aaaccacttt taaaggatag taattattct tgtttataac agtgccttaa ggtatgatgt   2220

atttctgatg gaagccattt tcacattcat gttcttcatg gattatttgt tacttgtcta   2280

agatgcaatt tgattttatg aagtatatac cctttaccca ccagagacag tacagaatcc   2340

ctgccctaaa atcccaggct taattgccct acaaagggtt attaatttaa aactccatta   2400

ttaggattac attttaaagt tttatttatg aattcccttt aaaaatgata tttcaaaggt   2460

aaaacaatac aatataaaga aaaaaataaa tatattaata ccggcttcct gtccccattt   2520

ttaacctcag ccttccctac tgtcaccaac aaccaagcta aataaagtca acagcctgat   2580

gtgtaaaa                                                            2588


<210>  2304
<211>  540
<212>  PRT
<213>  Homosapiens

<400>  2304

Met Asn Gly Glu Ala Ile Cys Ser Ala Leu Pro Thr Ile Pro Tyr His 
1               5                   10                  15      


Lys Leu Ala Asp Leu Arg Tyr Leu Ser Arg Gly Ala Ser Gly Thr Val 
            20                  25                  30          


Ser Ser Ala Arg His Ala Asp Trp Arg Val Gln Val Ala Val Lys His 
        35                  40                  45              


Leu His Ile His Thr Pro Leu Leu Asp Ser Glu Arg Lys Asp Val Leu 
    50                  55                  60                  


Arg Glu Ala Glu Ile Leu His Lys Ala Arg Phe Ser Tyr Ile Leu Pro 
65                  70                  75                  80  


Ile Leu Gly Ile Cys Asn Glu Pro Glu Phe Leu Gly Ile Val Thr Glu 
                85                  90                  95      


Tyr Met Pro Asn Gly Ser Leu Asn Glu Leu Leu His Arg Lys Thr Glu 
            100                 105                 110         


Tyr Pro Asp Val Ala Trp Pro Leu Arg Phe Arg Ile Leu His Glu Ile 
        115                 120                 125             


Ala Leu Gly Val Asn Tyr Leu His Asn Met Thr Pro Pro Leu Leu His 
    130                 135                 140                 


His Asp Leu Lys Thr Gln Asn Ile Leu Leu Asp Asn Glu Phe His Val 
145                 150                 155                 160 


Lys Ile Ala Asp Phe Gly Leu Ser Lys Trp Arg Met Met Ser Leu Ser 
                165                 170                 175     


Gln Ser Arg Ser Ser Lys Ser Ala Pro Glu Gly Gly Thr Ile Ile Tyr 
            180                 185                 190         


Met Pro Pro Glu Asn Tyr Glu Pro Gly Gln Lys Ser Arg Ala Ser Ile 
        195                 200                 205             


Lys His Asp Ile Tyr Ser Tyr Ala Val Ile Thr Trp Glu Val Leu Ser 
    210                 215                 220                 


Arg Lys Gln Pro Phe Glu Asp Val Thr Asn Pro Leu Gln Ile Met Tyr 
225                 230                 235                 240 


Ser Val Ser Gln Gly His Arg Pro Val Ile Asn Glu Glu Ser Leu Pro 
                245                 250                 255     


Tyr Asp Ile Pro His Arg Ala Arg Met Ile Ser Leu Ile Glu Ser Gly 
            260                 265                 270         


Trp Ala Gln Asn Pro Asp Glu Arg Pro Ser Phe Leu Lys Cys Leu Ile 
        275                 280                 285             


Glu Leu Glu Pro Val Leu Arg Thr Phe Glu Glu Ile Thr Phe Leu Glu 
    290                 295                 300                 


Ala Val Ile Gln Leu Lys Lys Thr Lys Leu Gln Ser Val Ser Ser Ala 
305                 310                 315                 320 


Ile His Leu Cys Asp Lys Lys Lys Met Glu Leu Ser Leu Asn Ile Pro 
                325                 330                 335     


Val Asn His Gly Pro Gln Glu Glu Ser Cys Gly Ser Ser Gln Leu His 
            340                 345                 350         


Glu Asn Ser Gly Ser Pro Glu Thr Ser Arg Ser Leu Pro Ala Pro Gln 
        355                 360                 365             


Asp Asn Asp Phe Leu Ser Arg Lys Ala Gln Asp Cys Tyr Phe Met Lys 
    370                 375                 380                 


Leu His His Cys Pro Gly Asn His Ser Trp Asp Ser Thr Ile Ser Gly 
385                 390                 395                 400 


Ser Gln Arg Ala Ala Phe Cys Asp His Lys Thr Thr Pro Cys Ser Ser 
                405                 410                 415     


Ala Ile Ile Asn Pro Leu Ser Thr Ala Gly Asn Ser Glu Arg Leu Gln 
            420                 425                 430         


Pro Gly Ile Ala Gln Gln Trp Ile Gln Ser Lys Arg Glu Asp Ile Val 
        435                 440                 445             


Asn Gln Met Thr Glu Ala Cys Leu Asn Gln Ser Leu Asp Ala Leu Leu 
    450                 455                 460                 


Ser Arg Asp Leu Ile Met Lys Glu Asp Tyr Glu Leu Val Ser Thr Lys 
465                 470                 475                 480 


Pro Thr Arg Thr Ser Lys Val Arg Gln Leu Leu Asp Thr Thr Asp Ile 
                485                 490                 495     


Gln Gly Glu Glu Phe Ala Lys Val Ile Val Gln Lys Leu Lys Asp Asn 
            500                 505                 510         


Lys Gln Met Gly Leu Gln Pro Tyr Pro Glu Ile Leu Val Val Ser Arg 
        515                 520                 525             


Ser Pro Ser Leu Asn Leu Leu Gln Asn Lys Ser Met 
    530                 535                 540 


<210>  2305
<211>  3413
<212>  DNA
<213>  Homosapiens

<400>  2305
atttccctgc tgctatgtga aatgtgcgtc ttctccttcc gccatgatta agtaagcaaa     60

cattttcctc taattcagat tctttaaaca aaagttgcaa atgaatgtag ccttcatcta    120

ttgtaaaatt aaagatggag atggtcaagg ggttaccgcc agtctgtttc ttgcgctgat    180

aatttttcta gacattaaat ctcaccattt gttcccaaca aagaaagaaa gacaggacca    240

ccagactcta cagggaagcc aagaggaaga agggaaggag cccagaaatg gagagaagct    300

ggactctagg gatggatctg gggatgctcc acaaagtgca gctgtggaga atgcagaaga    360

agagttggct agtgggacat tcccactgag gagcatggca gggggaatgt ctaatattca    420

ctaagagaat tcttgaaatg taacatttag atgaaactct tcaagtttcc ttaaaataca    480

aattcatgac tctctttctt tctctctctc tctttctctc tctctttggt atgttaaagt    540

aatcaaggaa agggattttg ttttataact gggttacaca ggggagagac cagaatagct    600

gaaagctgtg agacatgaag aaaattcaag atttaggaga catgcagaac atcagtgtct    660

aggcaaaatg gcagactgac caacccccac acactgaatc cctagagata ttaggacagg    720

gatattgaga aaaatttacc tttaagttgt aaaggacaag gcaactcaac atattgaatg    780

ccttgttgac aaccaggggc taatatttgg gatgcatatt gggcatagat gcacagaaaa    840

taatttatca gtgacattaa taatatgaca tctctttgtt gagaatttac tgctgtctta    900

atatcacaac tctaaggggt caacatccag aataaacttc ttatcttaca tatttaaaat    960

tatttgctag gctacatttt tcttagaaaa atgcatatct gaaacagaat attgattttt   1020

ttcctgggtc atacataaag accatcagaa attaattatt gaaaaaacac tgctatactc   1080

attagagata tattttaatt agattaattt tgcattaaca gtccatgaga agttacaact   1140

aacttgcaac gagacattaa catgcatcat gtttgatata agtaaaaatg gaaatgatta   1200

gaagtataca aatataaagt atgttgctag tatatgcaag cttaaaaaac ttttacctga   1260

tagaattagc aagagcagct atgttgagct tctttcagtt aaaagtcatt ttcggctatg   1320

tctccctaag gatagaaata tcactgcttt tgatctcatt tagaattctg ctcactttta   1380

ggaaagtagg gctgtttgga aatggtcagc catatcctta ctgaatttcc tagggcttga   1440

ctgcacctac tctagttaac aagtaagata tagttatata ttgtattata acttctcaaa   1500

gcacttatat tttgattttc cttcttttat gttcattatc ttcatttgga ctactccatg   1560

tgacaaaagc agttattttt cttctacccc ctaaactgga ccacatcgat gctcttaggt   1620

ccaaatcata ttctttaaga aacaagtgtt cactgaatga tttactgcat tatataatag   1680

gtactataca agacacctga ggccccccac accgtgaaaa cagatgtttc ttcctggagc   1740

ttgcccaata ggagagaaat ttttaattta ccctttctca gtaaaccatt atacaaaaca   1800

gaagtgaaat tatggaccca gtgaactcaa tctggctgac ttgcaacccc tatgtgttca   1860

taaacccact gaaatatata atttgttgtt tatattaaat atgcactgaa gcatgattag   1920

ataaacattg aaagtaaatt ttaattttaa ccatcagtgg aagtatatgg ggtgatttaa   1980

gtcattcata ttagtttatt tttatcaggt gttcctcctt gtccatagtg aaatacaata   2040

cagagattat agcctgtggc ttgacaggac atcttatagt tggtaacagg actacattaa   2100

aaggaaaaaa caataaataa ggatgtctaa ttatacagat aaagaaagca agttcactca   2160

ctcctccagg acagcaccag agacaacgtt agaaccaaga gtttcaaaac ctcgccttgt   2220

atggtttgcc tgatgccatg attaaagaaa agggggtggg gaactaagag aggaagccaa   2280

agagaaagaa ttcagtacca aacagcaata ttcagatgtt ttattaaata ataggaggtg   2340

ttttgacctt gctggtgaac agaggtgatc tcaaaacatt tgacagatat aattaaggcc   2400

ataaggcaat aattgcaaaa gtcaaggagc ccttgccacc tccaaagcat cacgtgtgga   2460

tgcaggaacc atattaacaa catgggtagt caaggagaaa gcagatagaa taaagctgta   2520

cccagcaata taaagggaca tgcaagtgtg tgttgtgctt aagagtaaac ttagggaaaa   2580

aagctcccca taacctcgag aaacgtttct ggatctgaga tatccattag cacatttaga   2640

aggtacctat ttccattatt gtgaaggagt tgtaaatgaa ataaacaact ttaaataata   2700

cctcccttgg tcaaactgca ttaagtattc cctgatggaa ttcattcatc atcattcaaa   2760

cagaatggtt tgcaactcaa cctgcctagt gtggggtctg gaattcccac cacagtcact   2820

gtgccttaag cactgttgca gcagaaggac ttgaagtaac acatgaatat ataatgccaa   2880

tttgcatgtc agcatggatt gttgaaattg aagttagtta attgtcacat tgtaacagga   2940

aaagaatcca agttttggag ctggttggaa ctgagttttc atcttctttc tctgctactt   3000

aactgtgtta tcctgaacaa gatactcaac ctccatgaga cacagtgacc atgtgaaata   3060

tatatgtaaa atgtctggca aacatctgat tcatgtaggt acccaaaatt agatcatttt   3120

cattttcttt tgcttccttg gaagttcaaa acaaaattct gaggtaagtt tcaattaaaa   3180

tgggtcaggc agacagattc cagcaaggtc aaagcatcct tttttcttta ataaaatatc   3240

tgaatatctg aacaagaaac aacttctgtt tctcaaggtt gaaatgatga attattgaac   3300

ttctgttgct gtttgttttc tctcttatct ccttactact acatataaat gagatatctt   3360

gctatcccac tgatatctca aattcagtat ttcccaaata aaacgtaatc ttt          3413


<210>  2306
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  2306

Met Asn Val Ala Phe Ile Tyr Cys Lys Ile Lys Asp Gly Asp Gly Gln 
1               5                   10                  15      


Gly Val Thr Ala Ser Leu Phe Leu Ala Leu Ile Ile Phe Leu Asp Ile 
            20                  25                  30          


Lys Ser His His Leu Phe Pro Thr Lys Lys Glu Arg Gln Asp His Gln 
        35                  40                  45              


Thr Leu Gln Gly Ser Gln Glu Glu Glu Gly Lys Glu Pro Arg Asn Gly 
    50                  55                  60                  


Glu Lys Leu Asp Ser Arg Asp Gly Ser Gly Asp Ala Pro Gln Ser Ala 
65                  70                  75                  80  


Ala Val Glu Asn Ala Glu Glu Glu Leu Ala Ser Gly Thr Phe Pro Leu 
                85                  90                  95      


Arg Ser Met Ala Gly Gly Met Ser Asn Ile His 
            100                 105         


<210>  2307
<211>  576
<212>  DNA
<213>  Homosapiens

<400>  2307
gcaacaagaa gctagggcag aggatttaga gggcaagcaa gcatgggcca ggactttgac     60

agcattcatc cagcagcatg cgaactccaa agagaacccg atctccaaag acaaaagtga    120

gcctgagggg agaaaccttg actctccagt tgaccactgt gtctctcgac acacggcata    180

tggtgaaacg gtgtgatgag aggcatggaa ggccattacc tcattcacag gaatctcagc    240

atggctctgc aacttcaaag aaggcagttc ggggaacagc agacacagct cctttggaaa    300

gaatatctgc cgcccgagga tgggctctgc ctatggaggc aacagtgagt gtcttcagag    360

cccatcagtg gcagtggaat taatgaagaa agcaatggca ggaaaagttg aataaagcag    420

acccttcatg gtaaatctgg ttggtaaatt gcctgtgacc acatgtggga caatcactgg    480

aggaacccca gttacatttg gtcagagtgt ggcgagggga accttctcag gaaagaaaat    540

agaggtcctg ttttaggaaa aaaaataaag atcaga                              576


<210>  2308
<211>  101
<212>  PRT
<213>  Homosapiens

<400>  2308

Met Arg Thr Pro Lys Arg Thr Arg Ser Pro Lys Thr Lys Val Ser Leu 
1               5                   10                  15      


Arg Gly Glu Thr Leu Thr Leu Gln Leu Thr Thr Val Ser Leu Asp Thr 
            20                  25                  30          


Arg His Met Val Lys Arg Cys Asp Glu Arg His Gly Arg Pro Leu Pro 
        35                  40                  45              


His Ser Gln Glu Ser Gln His Gly Ser Ala Thr Ser Lys Lys Ala Val 
    50                  55                  60                  


Arg Gly Thr Ala Asp Thr Ala Pro Leu Glu Arg Ile Ser Ala Ala Arg 
65                  70                  75                  80  


Gly Trp Ala Leu Pro Met Glu Ala Thr Val Ser Val Phe Arg Ala His 
                85                  90                  95      


Gln Trp Gln Trp Asn 
            100     


<210>  2309
<211>  3773
<212>  DNA
<213>  Homosapiens

<400>  2309
ggcttttgca ctagcagtag caaggaaggg gggtgggcgc tctttctttt tctcttagaa     60

gagggtttag cacaggtttt ttcgttctca cttccacacc accttaccgc ctcccgaccc    120

cccctctccc cctccccacc tatcgtcatg acggcctctc cggattactt ggtggtgctt    180

tttgggatca ctgctggggc caccggggcc aagctaggct cggatgagaa ggagttgatc    240

ctgctgttct ggaaagtcgt ggatctggcc aacaagaagg tgggacagtt gcacgaagtg    300

ctagttagac cggatcagtt ggaactgacg gaggactgca aagaagaaac taaaatagac    360

gtcgaaagcc tgtcctcggc gtcgcagctg gaccaagccc tccgacagtt taaccagtca    420

gtgagcaatg aactgaatat tggagtaggg acttccttct gtctctgtac tgatgggcag    480

cttcatgtca ggcaaatcct gcatcctgag gcttccaaga agaatgtact attacctgaa    540

tgcttctatt ccttttttga tcttcgaaaa gaattcaaga aatgttgccc tggttcacct    600

gatattgaca aactggacgt tgccacaatg acagagtatt taaattttga gaagagtagt    660

tcagtctctc gatatggagc ctctcaagtt gaagatatgg ggaatataat tttagcaatg    720

atttcagagc cttataatca caggttttca gatccagaga gagtgaatta caagtttgaa    780

agtggaactt gcagcaagat ggaacttatt gatgataaca ccgtagtcag ggcacgaggt    840

ttaccatggc agtcttcaga tcaagatatt gcaagattct tcaaaggact caatattgcc    900

aagggaggtg cagcactttg tctgaatgct cagggtcgaa ggaacggaga agctctggtt    960

aggtttgtaa gtgaggagca ccgagaccta gcactacaga ggcacaaaca tcacatgggg   1020

acccggtata ttgaggttta caaagcaaca ggtgaagatt tccttaaaat tgctggtggt   1080

acttccaatg aggtagccca gtttctctcc aaggaaaatc aagtcattgt ccgcatgcgg   1140

gggctccctt tcacggccac agctgaagaa gtggtggcct tctttggaca gcattgccct   1200

attactgggg gaaaggaagg catcctcttt gtcacctacc cagatggtag gccaacaggg   1260

gacgcttttg tcctctttgc ctgtgaggaa tatgcacaga atgcgttgag gaagcataaa   1320

gacttgttgg gtaaaagata cattgaactc ttcaggagca cagcagctga agttcagcag   1380

gtgctgaatc gattctcctc ggcccctctc attccacttc caacccctcc cattattcca   1440

gtactacctc agcaatttgt gccccctaca aatgttagag actgtatacg ccttcgaggt   1500

cttccctatg cagccacaat tgaggacatc ctggatttcc tgggggagtt cgccacagat   1560

attcgtactc atggggttca catggttttg aatcaccaag gccgcccatc aggagatgcc   1620

tttatccaga tgaagtctgc ggacagagca tttatggctg cacagaagtg tcataaaaaa   1680

aacatgaagg acagatatgt tgaagtcttt cagtgttcag ctgaggagat gaactttgtg   1740

ttaatggggg gcactttaaa tcgaaatggc ttatccccac cgccatgcct gtctcctccc   1800

tcctacacat ttccagctcc tgctgcagtt attcctacag aagctgccat ttaccagccc   1860

tctgtgattt tgaatccacg agcactgcag ccctccacag cgtactaccc agcaggcact   1920

cagctcttca tgaactacac agcgtactat cccagccccc caggttcgcc taatagtctt   1980

ggctacttcc ctacagctgc taatcttagc ggtgtccctc cacagcctgg cacggtggtc   2040

agaatgcagg gcctggccta caatactgga gttaaggaaa ttcttaactt ctcccaaggt   2100

taccagtatg caaccgagga tggacttata cacacaaatg accaggccag gactctaccc   2160

aaagaatggg tttgtattta agggccccag cagttagaac atcctcagaa aagaagtgtt   2220

tgaaagatgt atggtgatct tgaaacctcc agacacaaga aaacttctag caaattcagg   2280

ggaagtttgt ctacactcag gctgcagtat attcagcaaa cttgattgga caaacgggcc   2340

tgtgccttat cttttggtgg agtgaaaaaa tttgagccag tgaagccaaa tcgtaactta   2400

cagcaagcag catgcagcat acctggctct ttgctgattg caaataggca tttaaaatgt   2460

gaatttggaa tcagatgtct ccattacttc cagttaaagt ggcatcatag gcgtttccta   2520

agttttaagt cttggataaa aactccacca gtgtctacca tctccaccat gaactctgtt   2580

aaggaagctt cattttcgta tattcccgct cttttctctt catttccctg tcttctgcat   2640

aatcatgcct tcttgctaag taattcaagc ataagatctt ggaataataa aatcacaatc   2700

ttaggagaaa gaataaaatt gttattttcc cagtctcttg gccatgatga tatcttatga   2760

ttaaaaacaa attaaatttt aaaacacctg aagatatatt agaagaaatt gtgcaccctc   2820

cacaaaacat acaaagttta aaagtttgga tctttttctc agcaggtatc agttgtaaat   2880

aatgaattag gggccaaaat gcaaaacgaa aaatgaagca gctacatgta gttagtaatt   2940

tctagtttga actgtaattg aatattgtgg cttcatatgt attattttat attgtacttt   3000

tttcattatt gatggtttgg actttaataa gagaaattcc atagttttta atatcccaga   3060

agtgagacaa tttgaacagt gtattctaga aaacaataca ctaactgaac agaagtgaat   3120

gcttatatat attatgatag ccttaaacct ttttcctcta atgccttaac tgtcaaataa   3180

ttataacctt ttaaagcata ggactatagt cagcatgcta gactgagagg taaacactga   3240

tgcaattaga acaggtactg atgctgtcag tgtttaacac tatgtttagc tgtgtttatg   3300

ctataaaagt gcaatattag acactagcta gtactgctgc ctcatgtaac tccaaagaaa   3360

acaggatttc attaagtgca ttgaatgtgg ctatttctct aagttactca tattgtcctt   3420

tgcttgaatg caatgccgtg cagatttatg tggctgctat ttttattttc tgtgcattac   3480

tttaacacct taaagggaga agcaaacatt tccttcttca gctgactggc aatggccctt   3540

taactgcaat aggaagaaaa aaaaaaaagg tttgtgtgaa aattggtgat aactggcact   3600

taagatcgaa aagaaatttc tgtatacttg atgccttaag atgcccaaag ctgcccaaag   3660

ctctgaaaga ctttaagata ggcagtaatg cttactacaa tactactgag tttttgtaga   3720

gttaacattt gataataaaa cttgcctgtt taatctcaaa aaaaaaaaaa aaa          3773


<210>  2310
<211>  677
<212>  PRT
<213>  Homosapiens

<400>  2310

Met Thr Ala Ser Pro Asp Tyr Leu Val Val Leu Phe Gly Ile Thr Ala 
1               5                   10                  15      


Gly Ala Thr Gly Ala Lys Leu Gly Ser Asp Glu Lys Glu Leu Ile Leu 
            20                  25                  30          


Leu Phe Trp Lys Val Val Asp Leu Ala Asn Lys Lys Val Gly Gln Leu 
        35                  40                  45              


His Glu Val Leu Val Arg Pro Asp Gln Leu Glu Leu Thr Glu Asp Cys 
    50                  55                  60                  


Lys Glu Glu Thr Lys Ile Asp Val Glu Ser Leu Ser Ser Ala Ser Gln 
65                  70                  75                  80  


Leu Asp Gln Ala Leu Arg Gln Phe Asn Gln Ser Val Ser Asn Glu Leu 
                85                  90                  95      


Asn Ile Gly Val Gly Thr Ser Phe Cys Leu Cys Thr Asp Gly Gln Leu 
            100                 105                 110         


His Val Arg Gln Ile Leu His Pro Glu Ala Ser Lys Lys Asn Val Leu 
        115                 120                 125             


Leu Pro Glu Cys Phe Tyr Ser Phe Phe Asp Leu Arg Lys Glu Phe Lys 
    130                 135                 140                 


Lys Cys Cys Pro Gly Ser Pro Asp Ile Asp Lys Leu Asp Val Ala Thr 
145                 150                 155                 160 


Met Thr Glu Tyr Leu Asn Phe Glu Lys Ser Ser Ser Val Ser Arg Tyr 
                165                 170                 175     


Gly Ala Ser Gln Val Glu Asp Met Gly Asn Ile Ile Leu Ala Met Ile 
            180                 185                 190         


Ser Glu Pro Tyr Asn His Arg Phe Ser Asp Pro Glu Arg Val Asn Tyr 
        195                 200                 205             


Lys Phe Glu Ser Gly Thr Cys Ser Lys Met Glu Leu Ile Asp Asp Asn 
    210                 215                 220                 


Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp 
225                 230                 235                 240 


Ile Ala Arg Phe Phe Lys Gly Leu Asn Ile Ala Lys Gly Gly Ala Ala 
                245                 250                 255     


Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala Leu Val Arg 
            260                 265                 270         


Phe Val Ser Glu Glu His Arg Asp Leu Ala Leu Gln Arg His Lys His 
        275                 280                 285             


His Met Gly Thr Arg Tyr Ile Glu Val Tyr Lys Ala Thr Gly Glu Asp 
    290                 295                 300                 


Phe Leu Lys Ile Ala Gly Gly Thr Ser Asn Glu Val Ala Gln Phe Leu 
305                 310                 315                 320 


Ser Lys Glu Asn Gln Val Ile Val Arg Met Arg Gly Leu Pro Phe Thr 
                325                 330                 335     


Ala Thr Ala Glu Glu Val Val Ala Phe Phe Gly Gln His Cys Pro Ile 
            340                 345                 350         


Thr Gly Gly Lys Glu Gly Ile Leu Phe Val Thr Tyr Pro Asp Gly Arg 
        355                 360                 365             


Pro Thr Gly Asp Ala Phe Val Leu Phe Ala Cys Glu Glu Tyr Ala Gln 
    370                 375                 380                 


Asn Ala Leu Arg Lys His Lys Asp Leu Leu Gly Lys Arg Tyr Ile Glu 
385                 390                 395                 400 


Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu Asn Arg Phe 
                405                 410                 415     


Ser Ser Ala Pro Leu Ile Pro Leu Pro Thr Pro Pro Ile Ile Pro Val 
            420                 425                 430         


Leu Pro Gln Gln Phe Val Pro Pro Thr Asn Val Arg Asp Cys Ile Arg 
        435                 440                 445             


Leu Arg Gly Leu Pro Tyr Ala Ala Thr Ile Glu Asp Ile Leu Asp Phe 
    450                 455                 460                 


Leu Gly Glu Phe Ala Thr Asp Ile Arg Thr His Gly Val His Met Val 
465                 470                 475                 480 


Leu Asn His Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile Gln Met Lys 
                485                 490                 495     


Ser Ala Asp Arg Ala Phe Met Ala Ala Gln Lys Cys His Lys Lys Asn 
            500                 505                 510         


Met Lys Asp Arg Tyr Val Glu Val Phe Gln Cys Ser Ala Glu Glu Met 
        515                 520                 525             


Asn Phe Val Leu Met Gly Gly Thr Leu Asn Arg Asn Gly Leu Ser Pro 
    530                 535                 540                 


Pro Pro Cys Leu Ser Pro Pro Ser Tyr Thr Phe Pro Ala Pro Ala Ala 
545                 550                 555                 560 


Val Ile Pro Thr Glu Ala Ala Ile Tyr Gln Pro Ser Val Ile Leu Asn 
                565                 570                 575     


Pro Arg Ala Leu Gln Pro Ser Thr Ala Tyr Tyr Pro Ala Gly Thr Gln 
            580                 585                 590         


Leu Phe Met Asn Tyr Thr Ala Tyr Tyr Pro Ser Pro Pro Gly Ser Pro 
        595                 600                 605             


Asn Ser Leu Gly Tyr Phe Pro Thr Ala Ala Asn Leu Ser Gly Val Pro 
    610                 615                 620                 


Pro Gln Pro Gly Thr Val Val Arg Met Gln Gly Leu Ala Tyr Asn Thr 
625                 630                 635                 640 


Gly Val Lys Glu Ile Leu Asn Phe Ser Gln Gly Tyr Gln Tyr Ala Thr 
                645                 650                 655     


Glu Asp Gly Leu Ile His Thr Asn Asp Gln Ala Arg Thr Leu Pro Lys 
            660                 665                 670         


Glu Trp Val Cys Ile 
        675         


<210>  2311
<211>  2751
<212>  DNA
<213>  Homosapiens

<400>  2311
ttcggcacga ggaggaaggg gggtgggcgc tctttctttt tctcttagaa gagggtttag     60

cacaggtttt ttcgttctca cttccacacc accttaccgc ctcccgaccc cccctctccc    120

cctccccacc tatcgtcatg acggcctctc cggattactt ggtggtgctt tttgggatca    180

ctgctggggc caccggggcc aagctaggct cggatgagaa ggagttgatc ctgctgttct    240

ggaaagtcgt ggatctggcc aacaagaagg tgggacagtt gcacgaagtg ctagttagac    300

cggatcagtt ggaactgacg gaggactgca aagaagaaac taaaatagac gtcgaaagcc    360

tgtcctcggc gtcgcagctg gaccaagccc tccgacagtt taaccagtca gtgagcaatg    420

aactgaatat tggagtaggg acttccttct gtctctgtac tgatgggcag cttcatgtca    480

ggcaaatcct gcatcctgag gcttccaaga agaatgtact attacctgaa tgcttctatt    540

ccttttttga tcttcgaaaa gaattcaaga aatgttgccc tggttcacct gatattgaca    600

aactggacgt tgccacaatg acagagtatt taaattttga gaagagtagt tcagtctctc    660

gatatggagc ctctcaagtt gaagatatgg ggaatataat tttagcaatg atttcagagc    720

cttataatca caggttttca gatccagaga gagtgaatta caagtttgaa agtggaactt    780

gcagcaagat ggaacttatt gatgataaca ccgtagtcag ggcacgaggt ttaccatggc    840

agtcttcaga tcaagatatt gcaagattct tcaaaggact caatattgcc aagggaggtg    900

cagcactttg tctgaatgct cagggtcgaa ggaacggaga agctctggtt aggtttgtaa    960

gtgaggagca ccgagaccta gcactacaga ggcacaaaca tcacatgggg acccggtata   1020

ttgaggttta caaagcaaca ggtgaagatt tccttaaaat tgctggtggt acttccaatg   1080

aggtagccca gtttctctcc aaggaaaatc aagtcattgt tcgcatgcgg gggctccctt   1140

tcacggccac agctgaagaa gtggtggcct tctttggaca gcattgccct attactgggg   1200

gaaaggaagg catcctcttt gtcacctacc cagatggtag gccaacaggg gacgcttttg   1260

tcctctttgc ctgtgaggaa tatgcacaga atgcgttgag gaagcataaa gacttgttgg   1320

gtaaaagata cattgaactc ttcaggagca cagcagctga agttcagcag gtgctgaatc   1380

gattctcctc ggcccctctc attccacttc caacccctcc cattattcca gtactacctc   1440

agcaatttgt gccccctaca aatgttagag actgtatacg ccttcgaggt cttccctatg   1500

cagccacaat tgaggacatc ctggatttcc tgggggagtt cgccacagat attcgtactc   1560

atggggttca catggttttg aatcaccagg gccgcccatc aggagatgcc tttatccaga   1620

tgaagtctgc ggacagagca tttatggctg cacagaagtg tcataaaaaa aacatgaagg   1680

acagatatgt tgaagtcttt cagtgttcag ctgaggagat gaactttgtg ttaatggggg   1740

gcactttaaa tcgaaatggc ttatccccac cgccatgtaa gttaccatgc ctgtctcctc   1800

cctcctacac atttccagct cctgctgcag ttattcctac agaagctgcc atttaccagc   1860

cctctgtgat tttgaatcca cgagcactgc agccctccac agcgtactac ccagcaggca   1920

ctcagctctt catgaactac acagcgtact atcccagccc cccaggttcg cctaatagtc   1980

ttggctactt ccctacagct gctaatctta gcggtgtccc tccacagcct ggcacggtgg   2040

tcagaatgca gggcctggcc tacaatactg gagttaagga aattcttaac ttcttccaag   2100

gttaccagta tgcaaccgag gatggactta tacacacaaa tgaccaggcc aggactctac   2160

ccaaagaatg ggtttgtatt taagggcccc agcagttaga acatcctcag aaaagaagtg   2220

tttgaaagat gtatggtgat cttgaaacct ccagacacaa gaaaacttct agcaaattca   2280

ggggaagttt gtctacactc aggctgcagt attttcagca aacttgattg gacaaacggg   2340

cctgtgcctt atcttttggt ggagtgaaaa aatttgagct agtgaagcca aatcgtaact   2400

tacagcaagc agcatgcagc atacctggct ctttgctgat tgcaaatagg catttaaaat   2460

gtgaatttgg aatcagatgt ctccattact tccagttaaa gtggcatcat aggtgtttcc   2520

taagttttaa gtcttggata aaaactccac cagtgtctac catctccacc atgaactctg   2580

ttaaggaagc ttcatttttg tatattcccg ctcttttctc ttcatttccc tgtcttctgc   2640

ataatcatgc cttcttgcta agtaattcaa gcataagatc ttggaataat aaaatcacaa   2700

tcttaggaga aagaataaaa ttgttatttt cccaaaaaaa aaaaaaaaaa a            2751


<210>  2312
<211>  681
<212>  PRT
<213>  Homosapiens

<400>  2312

Met Thr Ala Ser Pro Asp Tyr Leu Val Val Leu Phe Gly Ile Thr Ala 
1               5                   10                  15      


Gly Ala Thr Gly Ala Lys Leu Gly Ser Asp Glu Lys Glu Leu Ile Leu 
            20                  25                  30          


Leu Phe Trp Lys Val Val Asp Leu Ala Asn Lys Lys Val Gly Gln Leu 
        35                  40                  45              


His Glu Val Leu Val Arg Pro Asp Gln Leu Glu Leu Thr Glu Asp Cys 
    50                  55                  60                  


Lys Glu Glu Thr Lys Ile Asp Val Glu Ser Leu Ser Ser Ala Ser Gln 
65                  70                  75                  80  


Leu Asp Gln Ala Leu Arg Gln Phe Asn Gln Ser Val Ser Asn Glu Leu 
                85                  90                  95      


Asn Ile Gly Val Gly Thr Ser Phe Cys Leu Cys Thr Asp Gly Gln Leu 
            100                 105                 110         


His Val Arg Gln Ile Leu His Pro Glu Ala Ser Lys Lys Asn Val Leu 
        115                 120                 125             


Leu Pro Glu Cys Phe Tyr Ser Phe Phe Asp Leu Arg Lys Glu Phe Lys 
    130                 135                 140                 


Lys Cys Cys Pro Gly Ser Pro Asp Ile Asp Lys Leu Asp Val Ala Thr 
145                 150                 155                 160 


Met Thr Glu Tyr Leu Asn Phe Glu Lys Ser Ser Ser Val Ser Arg Tyr 
                165                 170                 175     


Gly Ala Ser Gln Val Glu Asp Met Gly Asn Ile Ile Leu Ala Met Ile 
            180                 185                 190         


Ser Glu Pro Tyr Asn His Arg Phe Ser Asp Pro Glu Arg Val Asn Tyr 
        195                 200                 205             


Lys Phe Glu Ser Gly Thr Cys Ser Lys Met Glu Leu Ile Asp Asp Asn 
    210                 215                 220                 


Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp 
225                 230                 235                 240 


Ile Ala Arg Phe Phe Lys Gly Leu Asn Ile Ala Lys Gly Gly Ala Ala 
                245                 250                 255     


Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala Leu Val Arg 
            260                 265                 270         


Phe Val Ser Glu Glu His Arg Asp Leu Ala Leu Gln Arg His Lys His 
        275                 280                 285             


His Met Gly Thr Arg Tyr Ile Glu Val Tyr Lys Ala Thr Gly Glu Asp 
    290                 295                 300                 


Phe Leu Lys Ile Ala Gly Gly Thr Ser Asn Glu Val Ala Gln Phe Leu 
305                 310                 315                 320 


Ser Lys Glu Asn Gln Val Ile Val Arg Met Arg Gly Leu Pro Phe Thr 
                325                 330                 335     


Ala Thr Ala Glu Glu Val Val Ala Phe Phe Gly Gln His Cys Pro Ile 
            340                 345                 350         


Thr Gly Gly Lys Glu Gly Ile Leu Phe Val Thr Tyr Pro Asp Gly Arg 
        355                 360                 365             


Pro Thr Gly Asp Ala Phe Val Leu Phe Ala Cys Glu Glu Tyr Ala Gln 
    370                 375                 380                 


Asn Ala Leu Arg Lys His Lys Asp Leu Leu Gly Lys Arg Tyr Ile Glu 
385                 390                 395                 400 


Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu Asn Arg Phe 
                405                 410                 415     


Ser Ser Ala Pro Leu Ile Pro Leu Pro Thr Pro Pro Ile Ile Pro Val 
            420                 425                 430         


Leu Pro Gln Gln Phe Val Pro Pro Thr Asn Val Arg Asp Cys Ile Arg 
        435                 440                 445             


Leu Arg Gly Leu Pro Tyr Ala Ala Thr Ile Glu Asp Ile Leu Asp Phe 
    450                 455                 460                 


Leu Gly Glu Phe Ala Thr Asp Ile Arg Thr His Gly Val His Met Val 
465                 470                 475                 480 


Leu Asn His Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile Gln Met Lys 
                485                 490                 495     


Ser Ala Asp Arg Ala Phe Met Ala Ala Gln Lys Cys His Lys Lys Asn 
            500                 505                 510         


Met Lys Asp Arg Tyr Val Glu Val Phe Gln Cys Ser Ala Glu Glu Met 
        515                 520                 525             


Asn Phe Val Leu Met Gly Gly Thr Leu Asn Arg Asn Gly Leu Ser Pro 
    530                 535                 540                 


Pro Pro Cys Lys Leu Pro Cys Leu Ser Pro Pro Ser Tyr Thr Phe Pro 
545                 550                 555                 560 


Ala Pro Ala Ala Val Ile Pro Thr Glu Ala Ala Ile Tyr Gln Pro Ser 
                565                 570                 575     


Val Ile Leu Asn Pro Arg Ala Leu Gln Pro Ser Thr Ala Tyr Tyr Pro 
            580                 585                 590         


Ala Gly Thr Gln Leu Phe Met Asn Tyr Thr Ala Tyr Tyr Pro Ser Pro 
        595                 600                 605             


Pro Gly Ser Pro Asn Ser Leu Gly Tyr Phe Pro Thr Ala Ala Asn Leu 
    610                 615                 620                 


Ser Gly Val Pro Pro Gln Pro Gly Thr Val Val Arg Met Gln Gly Leu 
625                 630                 635                 640 


Ala Tyr Asn Thr Gly Val Lys Glu Ile Leu Asn Phe Phe Gln Gly Tyr 
                645                 650                 655     


Gln Tyr Ala Thr Glu Asp Gly Leu Ile His Thr Asn Asp Gln Ala Arg 
            660                 665                 670         


Thr Leu Pro Lys Glu Trp Val Cys Ile 
        675                 680     


<210>  2313
<211>  4204
<212>  DNA
<213>  Homosapiens

<400>  2313
ggggttcggc gacgcggagg gagggagagt ctgggccgcg cgggagccgc agggcgccct     60

agccttcgca gaaacgatgg cggacgaaga aggaccacct gtagagctgc gccaaagaaa    120

aaagccaaag tcttcagaaa ataaggaatc tgccaaagaa gagaaaatca gtgacattcc    180

aattcctgaa agagctccaa aacatgtatt atttcaacgc tttgcaaaga ttttcattgg    240

ctgtcttgca gcggttacta gtggtatgat gtatgctctc tacttatcag cataccatga    300

acggaaattc tggttttcca acaggcagga gcttgaacgg gaaatcacgt ttcagggtga    360

cagtgccatt tattactcct attataaaga tatgttaaag gcaccttcat ttgaaagagg    420

tgtttacgaa ctgacacaca ataacaaaac tgtatctctg aagactataa atgcagtgca    480

gcaaatgtct ctgtatccgg aacttattgc tagcatttta tatcaagcca ctggtagcaa    540

tgagattatt gagccagtgt atttctatat tggcattgtt tttggattgc aaggaatata    600

tgttactgct ttatttgtta caagttggct tatgagtgga acatggctag caggaatgct    660

tactgttgcg tggttcgtta ttaacagggt agatacaaca agaattgaat actccattcc    720

tttaagagaa aactgggcac taccatattt tgcatgccaa attgctgcac ttacaggcta    780

tttaaaaagc aacttaaata cttatggaga gaggttttgc tacttgttga tgagtgcttc    840

aacttacaca tttatgatga tgtgggagta tagccactat ctcctgtttc ttcaagcaat    900

atctctattc ctgctagata ccttttcagt ggagcaaagt gacaaggttt atgaagttta    960

taaaatctac atattttccc tctttctggg atatttacta cagtttgaga atccagcttt   1020

gttggtatct cctttattaa gtttagtagc agccttaatg cttgctaagt gccttcagct   1080

gaatgtgaag aaaggaagtt ttgtagctaa aataataaaa gtgattaatt tttacttggt   1140

gtgtactctg acaataacat tgaatattat aatgaagatg tttgtcccac acaaagaaaa   1200

tgggcacatg ctgaaattcc ttgaagtaaa atttggacta aatatgacca agaattttac   1260

aatgaattgg ctcctctgtc aagaatccct gcaggcacca tctcaagatt tttttctgcg   1320

attgacacag tcttctttat tacctttcta cattctagtg ttaattattt gttttctttc   1380

tatgttgcaa gttattttta ggaggattaa tggtaagtcc ctgaaggaaa ctgttactct   1440

tgaagatgga cgaattggag aaagaccaga aataatttat catgtaattc acactatttt   1500

attgggttct cttgcaatgg ttatagaagg cttgaagtac atctggattc cttatgtgtg   1560

catgttagca gcatttggtg tatgttctcc cgaactttgg atgacacttt tcaagtggct   1620

tcgattaaga actgtacacc caatattgtt ggctcttatt ctgagcatgg ccgtgcctac   1680

tataataggt ctcagcttat ggaaagagtt ttttcccaga ttaatgacag aattaatgga   1740

actacaggaa ttctatgacc cagatacagt ggaacttatg acctggataa aaaggcaagc   1800

tccagttgca gctgtgtttg cagggagtcc acagttaatg ggtgcgatta aattatgcac   1860

tggatggatg gtgacaagtt tgcctcttta caatgatgat gatcttctca agagaaatga   1920

aaatatctac caaatctatt caaagcgatc tgctgaggat atttataaaa tactgacatc   1980

ttacaaagct aattacctaa ttgtagagga tgctatctgc aatgaggtgg gacccatgag   2040

aggctgtagg gttaaagatt tattagacat tgcaaatggc cacatggttt gtgaagaagg   2100

tgacaagcta acctactcaa aatatgggcg attttgtcat gaggtcaaaa ttaactattc   2160

tccatatgtg aattatttca ctagagtata ctggaacaga tcctactttg tatataaaat   2220

caacactgtg atatccttcc agtcttgaaa aataacagag ccttcatttc aaagactacc   2280

tgaagtaaaa tgcagttttc ttctacctac tcggtgtctt ttgcagatca gagtatggac   2340

atttgaaata ttgctgcttc tttccccctt ctgctgttaa ctggatccag agttctgtgg   2400

gaaatagaag atcaagcatt actgtccttt gattaaatgt gatatctacc actctgcaat   2460

attccagaca ggtgtcttcc ttaccgttac atggtcttta acacttttac tgattgcaat   2520

attttcccca taaaatcttc attctattat aatattgatc ttgaatttga atatgtgcaa   2580

ggtcagatac atttctcaaa cataacattt aataaataat gtgatataat tatttaatag   2640

aaagaataat tccgaccttc aagcaagttt ctgaaggtat tttatgatgt ataacaactg   2700

aagttttaca ataaaaacta atttaaatgt tagctgaaga tatgtggcat ttaaattaaa   2760

atggaaatta tataaaggaa agtgattttt aaggatatac ataaagatat atttagaatt   2820

ttcatgatac tgttctcctc atctactgct tatgttaagt gagaactttc ttagtaatac   2880

ataatgcatg atgttactgc attttctaaa tgactagtaa gtgattagtt ttttcactta   2940

tgcctattaa tttgatacca atttaatcat gataaaacaa taaccgttaa catatatttt   3000

gttaaatgga catttaaaag aatgttgttc aggttttttt tttttaaata ctgatatggg   3060

gcatacaatc tattcacatg ttttctactg aagtactaag taaaaaaatt aaatcattat   3120

cagaataaaa atatgtgttc taaaattagc aacaatttct ggggatacat gcagatgttg   3180

ttaaacgtac ctctgcatac agatatatta taaaacacaa gcaatgttat ttatgaaact   3240

gtgatgcagt cttcaacatc aagaaaaaat gacaactata ataaaattta caacacagtt   3300

tcacagtcta aatgctatgt tcctttaagt attttcatat ttttaatcat ttattaagag   3360

aaaattgtga aaagttaatt tggccttata gagagattca ggatagatgt agcctataga   3420

tgtgtcattt taataagttg ggatacgtgt ttagtttttc cttatattcc tgttcagtga   3480

acagattttc ataattctca cttgttaaag tgctgcaaaa attgcatttt cagtactcta   3540

aattactaca ttagaagaga gcatttctcc attgtcttta ttttctgtta tatatgtgtt   3600

gtaaaagtac actacattag aagggagctt ttccgttgtc tttattttct gttatacatg   3660

tgttgttaaa gtacatgcat tcttagacta actctcagat gctttgctct tttggagctg   3720

aagaattgtt tgatggtgat gtcatatatc tgatagatta gtttcagtgg ttctcatttc   3780

acttttatac gtaatttctt aactatatta agatagttgc aggcagtgta cctcaggttg   3840

actctgtaca tctgaatagt gagtcactag tattttgctt caagccttct gaaaatataa   3900

ccatagttac ctaagcacac agtgaatagt cacatggtag tacttgtgat tagagcatgt   3960

aaaacaatgt aattgaaaag tcagcttcca tattttgtag gggaaataga acaccctact   4020

ttttatctag tgtgaaatat ttaatcgaat ttttgttgat ttatattatg ttacctgtgc   4080

tgaattaggt ttggtacttg tgttttgttt gacatattag taagttgctt ttgcttcttt   4140

ctgtcaactt attttttaaa taaaattgat ctggaaaaat taaaaaaaaa agaaaaaaaa   4200

aaaa                                                                4204


<210>  2314
<211>  723
<212>  PRT
<213>  Homosapiens

<400>  2314

Met Ala Asp Glu Glu Gly Pro Pro Val Glu Leu Arg Gln Arg Lys Lys 
1               5                   10                  15      


Pro Lys Ser Ser Glu Asn Lys Glu Ser Ala Lys Glu Glu Lys Ile Ser 
            20                  25                  30          


Asp Ile Pro Ile Pro Glu Arg Ala Pro Lys His Val Leu Phe Gln Arg 
        35                  40                  45              


Phe Ala Lys Ile Phe Ile Gly Cys Leu Ala Ala Val Thr Ser Gly Met 
    50                  55                  60                  


Met Tyr Ala Leu Tyr Leu Ser Ala Tyr His Glu Arg Lys Phe Trp Phe 
65                  70                  75                  80  


Ser Asn Arg Gln Glu Leu Glu Arg Glu Ile Thr Phe Gln Gly Asp Ser 
                85                  90                  95      


Ala Ile Tyr Tyr Ser Tyr Tyr Lys Asp Met Leu Lys Ala Pro Ser Phe 
            100                 105                 110         


Glu Arg Gly Val Tyr Glu Leu Thr His Asn Asn Lys Thr Val Ser Leu 
        115                 120                 125             


Lys Thr Ile Asn Ala Val Gln Gln Met Ser Leu Tyr Pro Glu Leu Ile 
    130                 135                 140                 


Ala Ser Ile Leu Tyr Gln Ala Thr Gly Ser Asn Glu Ile Ile Glu Pro 
145                 150                 155                 160 


Val Tyr Phe Tyr Ile Gly Ile Val Phe Gly Leu Gln Gly Ile Tyr Val 
                165                 170                 175     


Thr Ala Leu Phe Val Thr Ser Trp Leu Met Ser Gly Thr Trp Leu Ala 
            180                 185                 190         


Gly Met Leu Thr Val Ala Trp Phe Val Ile Asn Arg Val Asp Thr Thr 
        195                 200                 205             


Arg Ile Glu Tyr Ser Ile Pro Leu Arg Glu Asn Trp Ala Leu Pro Tyr 
    210                 215                 220                 


Phe Ala Cys Gln Ile Ala Ala Leu Thr Gly Tyr Leu Lys Ser Asn Leu 
225                 230                 235                 240 


Asn Thr Tyr Gly Glu Arg Phe Cys Tyr Leu Leu Met Ser Ala Ser Thr 
                245                 250                 255     


Tyr Thr Phe Met Met Met Trp Glu Tyr Ser His Tyr Leu Leu Phe Leu 
            260                 265                 270         


Gln Ala Ile Ser Leu Phe Leu Leu Asp Thr Phe Ser Val Glu Gln Ser 
        275                 280                 285             


Asp Lys Val Tyr Glu Val Tyr Lys Ile Tyr Ile Phe Ser Leu Phe Leu 
    290                 295                 300                 


Gly Tyr Leu Leu Gln Phe Glu Asn Pro Ala Leu Leu Val Ser Pro Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ala Ala Leu Met Leu Ala Lys Cys Leu Gln Leu Asn 
                325                 330                 335     


Val Lys Lys Gly Ser Phe Val Ala Lys Ile Ile Lys Val Ile Asn Phe 
            340                 345                 350         


Tyr Leu Val Cys Thr Leu Thr Ile Thr Leu Asn Ile Ile Met Lys Met 
        355                 360                 365             


Phe Val Pro His Lys Glu Asn Gly His Met Leu Lys Phe Leu Glu Val 
    370                 375                 380                 


Lys Phe Gly Leu Asn Met Thr Lys Asn Phe Thr Met Asn Trp Leu Leu 
385                 390                 395                 400 


Cys Gln Glu Ser Leu Gln Ala Pro Ser Gln Asp Phe Phe Leu Arg Leu 
                405                 410                 415     


Thr Gln Ser Ser Leu Leu Pro Phe Tyr Ile Leu Val Leu Ile Ile Cys 
            420                 425                 430         


Phe Leu Ser Met Leu Gln Val Ile Phe Arg Arg Ile Asn Gly Lys Ser 
        435                 440                 445             


Leu Lys Glu Thr Val Thr Leu Glu Asp Gly Arg Ile Gly Glu Arg Pro 
    450                 455                 460                 


Glu Ile Ile Tyr His Val Ile His Thr Ile Leu Leu Gly Ser Leu Ala 
465                 470                 475                 480 


Met Val Ile Glu Gly Leu Lys Tyr Ile Trp Ile Pro Tyr Val Cys Met 
                485                 490                 495     


Leu Ala Ala Phe Gly Val Cys Ser Pro Glu Leu Trp Met Thr Leu Phe 
            500                 505                 510         


Lys Trp Leu Arg Leu Arg Thr Val His Pro Ile Leu Leu Ala Leu Ile 
        515                 520                 525             


Leu Ser Met Ala Val Pro Thr Ile Ile Gly Leu Ser Leu Trp Lys Glu 
    530                 535                 540                 


Phe Phe Pro Arg Leu Met Thr Glu Leu Met Glu Leu Gln Glu Phe Tyr 
545                 550                 555                 560 


Asp Pro Asp Thr Val Glu Leu Met Thr Trp Ile Lys Arg Gln Ala Pro 
                565                 570                 575     


Val Ala Ala Val Phe Ala Gly Ser Pro Gln Leu Met Gly Ala Ile Lys 
            580                 585                 590         


Leu Cys Thr Gly Trp Met Val Thr Ser Leu Pro Leu Tyr Asn Asp Asp 
        595                 600                 605             


Asp Leu Leu Lys Arg Asn Glu Asn Ile Tyr Gln Ile Tyr Ser Lys Arg 
    610                 615                 620                 


Ser Ala Glu Asp Ile Tyr Lys Ile Leu Thr Ser Tyr Lys Ala Asn Tyr 
625                 630                 635                 640 


Leu Ile Val Glu Asp Ala Ile Cys Asn Glu Val Gly Pro Met Arg Gly 
                645                 650                 655     


Cys Arg Val Lys Asp Leu Leu Asp Ile Ala Asn Gly His Met Val Cys 
            660                 665                 670         


Glu Glu Gly Asp Lys Leu Thr Tyr Ser Lys Tyr Gly Arg Phe Cys His 
        675                 680                 685             


Glu Val Lys Ile Asn Tyr Ser Pro Tyr Val Asn Tyr Phe Thr Arg Val 
    690                 695                 700                 


Tyr Trp Asn Arg Ser Tyr Phe Val Tyr Lys Ile Asn Thr Val Ile Ser 
705                 710                 715                 720 


Phe Gln Ser 
            


<210>  2315
<211>  3393
<212>  DNA
<213>  Homosapiens

<400>  2315
gtttccggga cgttcggagg gtggcctctc tcccaccggg ttccgcatac cccaggcacc     60

ggcccgcatc caagtgtcag gttggagccg ggaagcggcc ctggtggtag cggcggcggg    120

ggcaggatga gcgcggaggc ggcggaccgg gaggcggcca cctccagccg gccctgcacc    180

ccgccgcaga cctgctggtt tgagtttctg ctggaggagt cactgttgga gaaacatctg    240

cgcaagccct gcccggatcc tgcaccagtt caacttatag ttcagttttt ggaacaggct    300

tccaaacctt cagttaatga acaaaaccaa gttcaacctc cgcctgataa caagagaaat    360

cgtattttaa aactacttgc tcttaaagtt gctgcacatt tgaagtggga cttagacata    420

ttagagaaaa gtttgtctgt tccagtattg aatatgctac taaatgaact actctgcatc    480

agtaaagttc ctcctgggac aaagcatgta gacatggatc tggccacttt acctccgacc    540

actgccatgg ctgtacttct ctataataga tgggcaatta ggacaattgt tcaaagtagt    600

tttccagtca aacaggcaaa acccggaccc cctcagttaa gtgttatgaa tcaaatgcaa    660

caggaaaaag agctaacaga aaacattttg aaagtgctca aagaacaagc tgctgattct    720

attttggtac tagaagcagc cctaaaatta aacaaggatc tttatgtcca tacgatgaga    780

actctagatt tattggccat ggaaccaggc atggtaaatg gagaaactga gagttctact    840

gctggattga aagtcaaaac cgaagaaatg cagtgccagg tgtgctatga tttgggcgca    900

gcatacttcc agcaaggctc cacaaattca gctgtctatg aaaatgccag ggaaaaattt    960

tttagaacca aagaactaat tgcagagata ggttcattat ctcttcattg taccatagat   1020

gagaagcggt tagctggcta ttgtcaagca tgtgatgttc ttgtaccttc ttctgatagt   1080

acatctcaac agttgactcc atatagtcaa gtccatattt gtttgagatc tggcaactat   1140

caggaggtaa tacagatttt cattgaagac aacttaacct tgagtttacc tgtccagttc   1200

cgacagtcag tcctaagaga actctttaag aaagctcaac agggaaatga agctctagat   1260

gaaatctgtt ttaaagtttg tgcctgtaat acagtccgtg atatactgga aggcagaaca   1320

attagtgttc aatttaacca gctatttctt agaccaaata aagagaaaat agactttctt   1380

cttgaggtat gttcaagatc agtaaattta gaaaaagctt cagagtcttt gaaaggaaac   1440

atggctgctt ttctaaagaa tgtgtgtctg gggttggaag atctgcagta tgttttcatg   1500

atttcttcac atgagctttt cattacattg ttgaaagatg aagaacgaaa gctacttgtt   1560

gatcagatga ggaagagatc ccctagagta aatctgtgca ttaaacctgt aacttcattt   1620

tatgatatcc cagcttcagc aagtgtcaac attggtcagt tagagcatca acttatattg   1680

tcagtggatc cttggaggat tagacaaatt ttaattgaat tacatggtat gacttcagag   1740

cgccagttct ggacagtgtc taataagtgg gaagtacctt ctgtctatag tggtgttatc   1800

ctgggaatta aagacaattt aacaagagat ttggtttata ttcttatggc caaaggtttg   1860

cactgcagta ctgttaagga cttttcccat gctaaacagc tctttgctgc ttgtttggag   1920

ttggtaacag agttctcacc gaagcttcgt caggtcatgc tgaatgagat gttgcttttg   1980

gatattcata cacacgaagc tgggacaggg caggcaggag agagaccgcc atccgacctt   2040

ataagtagag tacgaggcta tctggaaatg aggcttcctg atattcctct tcgtcaagtt   2100

atagctgagg aatgtgttgc ctttatgtta aactggagag aaaatgaata ccttacactc   2160

caagttcctg catttttgct tcagagtaat ccatatgtaa agcttggaca gcttttagca   2220

gctacatgca aagaacttcc aggccctaaa gaaagcagac ggactgccaa agacctttgg   2280

gaagttgttg ttcaaatctg tagtgtgtcc agtcagcaca aacgaggaaa tgatggcaga   2340

gttagtttaa taaaacagag ggaatctacg ttaggtatca tgtatcggag tgaactgctt   2400

tcttttatca aaaaattacg agaaccactc gttttgacta ttattttatc actctttgtg   2460

aaacttcaca atgttcggga ggacattgtg aatgatatta cagctgaaca catttctatt   2520

tggccatctt ccattcccaa cctccagtct gtggactttg aagctgtggc aatcacagtg   2580

aaagagctag ttcgatatac actcagtata aatccaaata accattcttg gttaattatc   2640

caggcagata tttactttgc aacgaatcag tattcagcag ctcttcacta ttacctccag   2700

gcaggagctg tgtgttctga cttctttaac aaggctgtgc cccctgatgt ttatacagac   2760

caggtaataa aacgaatgat aaaatgttgt tctttgctga attgccacac acaggtggct   2820

attttatgtc agttcctcag agaaattgac tacaaaacag cgtttaaatc tctgcaagaa   2880

caaaacagtc atgatgctat ggactcctac tacgactaca tatgggatgt taccattttg   2940

gaatacttga cttatcttca tcataaaaga ggagaaacag ataaaagaca aattgcaatc   3000

aaagccatcg gccagacaga gttgaatgca agcaatccag aagaagtgtt acagctggca   3060

gcgcagagaa ggaaaaaaaa gtttctccaa gcaatggcaa aactttactt ttaagcagtt   3120

aaattttttt aacttttatt ttttaaacaa tgggctaaaa ataaacagta ttaaaaggtt   3180

aagtttatat aatacatatg tacacaatta gtggtgtttt cttttcagac aaaatactga   3240

aacaaatatt agtttaaaaa caaactatac agaagacttc ataccgtaac aataaatgta   3300

tagtttcttc aaagggagaa gagattcaca tatctgataa caaaataaac tagcaatcta   3360

gttttctaat ctaaaaaaaa aaaaaaaaaa aaa                                3393


<210>  2316
<211>  995
<212>  PRT
<213>  Homosapiens

<400>  2316

Met Ser Ala Glu Ala Ala Asp Arg Glu Ala Ala Thr Ser Ser Arg Pro 
1               5                   10                  15      


Cys Thr Pro Pro Gln Thr Cys Trp Phe Glu Phe Leu Leu Glu Glu Ser 
            20                  25                  30          


Leu Leu Glu Lys His Leu Arg Lys Pro Cys Pro Asp Pro Ala Pro Val 
        35                  40                  45              


Gln Leu Ile Val Gln Phe Leu Glu Gln Ala Ser Lys Pro Ser Val Asn 
    50                  55                  60                  


Glu Gln Asn Gln Val Gln Pro Pro Pro Asp Asn Lys Arg Asn Arg Ile 
65                  70                  75                  80  


Leu Lys Leu Leu Ala Leu Lys Val Ala Ala His Leu Lys Trp Asp Leu 
                85                  90                  95      


Asp Ile Leu Glu Lys Ser Leu Ser Val Pro Val Leu Asn Met Leu Leu 
            100                 105                 110         


Asn Glu Leu Leu Cys Ile Ser Lys Val Pro Pro Gly Thr Lys His Val 
        115                 120                 125             


Asp Met Asp Leu Ala Thr Leu Pro Pro Thr Thr Ala Met Ala Val Leu 
    130                 135                 140                 


Leu Tyr Asn Arg Trp Ala Ile Arg Thr Ile Val Gln Ser Ser Phe Pro 
145                 150                 155                 160 


Val Lys Gln Ala Lys Pro Gly Pro Pro Gln Leu Ser Val Met Asn Gln 
                165                 170                 175     


Met Gln Gln Glu Lys Glu Leu Thr Glu Asn Ile Leu Lys Val Leu Lys 
            180                 185                 190         


Glu Gln Ala Ala Asp Ser Ile Leu Val Leu Glu Ala Ala Leu Lys Leu 
        195                 200                 205             


Asn Lys Asp Leu Tyr Val His Thr Met Arg Thr Leu Asp Leu Leu Ala 
    210                 215                 220                 


Met Glu Pro Gly Met Val Asn Gly Glu Thr Glu Ser Ser Thr Ala Gly 
225                 230                 235                 240 


Leu Lys Val Lys Thr Glu Glu Met Gln Cys Gln Val Cys Tyr Asp Leu 
                245                 250                 255     


Gly Ala Ala Tyr Phe Gln Gln Gly Ser Thr Asn Ser Ala Val Tyr Glu 
            260                 265                 270         


Asn Ala Arg Glu Lys Phe Phe Arg Thr Lys Glu Leu Ile Ala Glu Ile 
        275                 280                 285             


Gly Ser Leu Ser Leu His Cys Thr Ile Asp Glu Lys Arg Leu Ala Gly 
    290                 295                 300                 


Tyr Cys Gln Ala Cys Asp Val Leu Val Pro Ser Ser Asp Ser Thr Ser 
305                 310                 315                 320 


Gln Gln Leu Thr Pro Tyr Ser Gln Val His Ile Cys Leu Arg Ser Gly 
                325                 330                 335     


Asn Tyr Gln Glu Val Ile Gln Ile Phe Ile Glu Asp Asn Leu Thr Leu 
            340                 345                 350         


Ser Leu Pro Val Gln Phe Arg Gln Ser Val Leu Arg Glu Leu Phe Lys 
        355                 360                 365             


Lys Ala Gln Gln Gly Asn Glu Ala Leu Asp Glu Ile Cys Phe Lys Val 
    370                 375                 380                 


Cys Ala Cys Asn Thr Val Arg Asp Ile Leu Glu Gly Arg Thr Ile Ser 
385                 390                 395                 400 


Val Gln Phe Asn Gln Leu Phe Leu Arg Pro Asn Lys Glu Lys Ile Asp 
                405                 410                 415     


Phe Leu Leu Glu Val Cys Ser Arg Ser Val Asn Leu Glu Lys Ala Ser 
            420                 425                 430         


Glu Ser Leu Lys Gly Asn Met Ala Ala Phe Leu Lys Asn Val Cys Leu 
        435                 440                 445             


Gly Leu Glu Asp Leu Gln Tyr Val Phe Met Ile Ser Ser His Glu Leu 
    450                 455                 460                 


Phe Ile Thr Leu Leu Lys Asp Glu Glu Arg Lys Leu Leu Val Asp Gln 
465                 470                 475                 480 


Met Arg Lys Arg Ser Pro Arg Val Asn Leu Cys Ile Lys Pro Val Thr 
                485                 490                 495     


Ser Phe Tyr Asp Ile Pro Ala Ser Ala Ser Val Asn Ile Gly Gln Leu 
            500                 505                 510         


Glu His Gln Leu Ile Leu Ser Val Asp Pro Trp Arg Ile Arg Gln Ile 
        515                 520                 525             


Leu Ile Glu Leu His Gly Met Thr Ser Glu Arg Gln Phe Trp Thr Val 
    530                 535                 540                 


Ser Asn Lys Trp Glu Val Pro Ser Val Tyr Ser Gly Val Ile Leu Gly 
545                 550                 555                 560 


Ile Lys Asp Asn Leu Thr Arg Asp Leu Val Tyr Ile Leu Met Ala Lys 
                565                 570                 575     


Gly Leu His Cys Ser Thr Val Lys Asp Phe Ser His Ala Lys Gln Leu 
            580                 585                 590         


Phe Ala Ala Cys Leu Glu Leu Val Thr Glu Phe Ser Pro Lys Leu Arg 
        595                 600                 605             


Gln Val Met Leu Asn Glu Met Leu Leu Leu Asp Ile His Thr His Glu 
    610                 615                 620                 


Ala Gly Thr Gly Gln Ala Gly Glu Arg Pro Pro Ser Asp Leu Ile Ser 
625                 630                 635                 640 


Arg Val Arg Gly Tyr Leu Glu Met Arg Leu Pro Asp Ile Pro Leu Arg 
                645                 650                 655     


Gln Val Ile Ala Glu Glu Cys Val Ala Phe Met Leu Asn Trp Arg Glu 
            660                 665                 670         


Asn Glu Tyr Leu Thr Leu Gln Val Pro Ala Phe Leu Leu Gln Ser Asn 
        675                 680                 685             


Pro Tyr Val Lys Leu Gly Gln Leu Leu Ala Ala Thr Cys Lys Glu Leu 
    690                 695                 700                 


Pro Gly Pro Lys Glu Ser Arg Arg Thr Ala Lys Asp Leu Trp Glu Val 
705                 710                 715                 720 


Val Val Gln Ile Cys Ser Val Ser Ser Gln His Lys Arg Gly Asn Asp 
                725                 730                 735     


Gly Arg Val Ser Leu Ile Lys Gln Arg Glu Ser Thr Leu Gly Ile Met 
            740                 745                 750         


Tyr Arg Ser Glu Leu Leu Ser Phe Ile Lys Lys Leu Arg Glu Pro Leu 
        755                 760                 765             


Val Leu Thr Ile Ile Leu Ser Leu Phe Val Lys Leu His Asn Val Arg 
    770                 775                 780                 


Glu Asp Ile Val Asn Asp Ile Thr Ala Glu His Ile Ser Ile Trp Pro 
785                 790                 795                 800 


Ser Ser Ile Pro Asn Leu Gln Ser Val Asp Phe Glu Ala Val Ala Ile 
                805                 810                 815     


Thr Val Lys Glu Leu Val Arg Tyr Thr Leu Ser Ile Asn Pro Asn Asn 
            820                 825                 830         


His Ser Trp Leu Ile Ile Gln Ala Asp Ile Tyr Phe Ala Thr Asn Gln 
        835                 840                 845             


Tyr Ser Ala Ala Leu His Tyr Tyr Leu Gln Ala Gly Ala Val Cys Ser 
    850                 855                 860                 


Asp Phe Phe Asn Lys Ala Val Pro Pro Asp Val Tyr Thr Asp Gln Val 
865                 870                 875                 880 


Ile Lys Arg Met Ile Lys Cys Cys Ser Leu Leu Asn Cys His Thr Gln 
                885                 890                 895     


Val Ala Ile Leu Cys Gln Phe Leu Arg Glu Ile Asp Tyr Lys Thr Ala 
            900                 905                 910         


Phe Lys Ser Leu Gln Glu Gln Asn Ser His Asp Ala Met Asp Ser Tyr 
        915                 920                 925             


Tyr Asp Tyr Ile Trp Asp Val Thr Ile Leu Glu Tyr Leu Thr Tyr Leu 
    930                 935                 940                 


His His Lys Arg Gly Glu Thr Asp Lys Arg Gln Ile Ala Ile Lys Ala 
945                 950                 955                 960 


Ile Gly Gln Thr Glu Leu Asn Ala Ser Asn Pro Glu Glu Val Leu Gln 
                965                 970                 975     


Leu Ala Ala Gln Arg Arg Lys Lys Lys Phe Leu Gln Ala Met Ala Lys 
            980                 985                 990         


Leu Tyr Phe 
        995 


<210>  2317
<211>  2613
<212>  DNA
<213>  Homosapiens

<400>  2317
agcgggtgcg gggcgggacc ggcccggcct atatattggg ttggcgccgg cgccagctga     60

gccgagcggt agctggtctg gcgaggtttt atacacctga aagaagagaa tgtcaagacg    120

aagtagccgt ttacaagcta agcagcagcc ccagcccagc cagacggaat ccccccaaga    180

agcccagata atccaggcca agaagaggaa aactacccag gatgtcaaaa aaagaagaga    240

ggaggtcacc aagaaacatc agtatgaaat taggaattgt tggccacctg tattatctgg    300

ggggatcagt ccttgcatta tcattgaaac acctcacaaa gaaataggaa caagtgattt    360

ctccagattt acaaattaca gatttaaaaa tctttttatt aatccttcac ctttgcctga    420

tttaagctgg ggatgttcaa aagaagtctg gctaaacatg ttaaaaaagg agagcagata    480

tgttcatgac aaacattttg aagttctgca ttctgacttg gaaccacaga tgaggtccat    540

acttctagac tggcttttag aggtatgtga agtatacaca cttcataggg aaacatttta    600

tcttgcttac gtcactgatg gtgcttgcag tgaagaggat atcttaagga tggaactcat    660

tatattaaag gctttaaaat gggaactttg tcctgtaaca atcatctcct ggctaaatct    720

ctttctccaa gttgatgctc ttaaagatgc tcctaaagtt cttctacctc agtattctca    780

ggaaacattc attcaaatag ctcagctttt agatctgtgt attctagcca ttgattcatt    840

agagttccag tacagaatac tgactgctgc tgccttgtgc cattttacct ccattgaagt    900

ggttaagaaa gcctcaggtt tggagtggga cagtatttca gaatgtgtag attggatggt    960

accttttgtc aatgtagtaa aaagtactag tccagtgaag ctgaagactt ttaagaagat   1020

tcctatggaa gacagacata atatccagac acatacaaac tatttggcta tgctggagga   1080

agtaaattac ataaacacct tcagaaaagg gggacagttg tcaccagtgt gcaatggagg   1140

cattatgaca ccaccgaaga gcactgaaaa accaccagga aaacactaaa gaagataact   1200

aagcaaacaa gttggaattc accaagattg ggtagaactg gtatcactga actactaaag   1260

ttttacagaa agtagtgctg tgattgattg ccctagccaa ttcacaagtt acactgccat   1320

tctgatttta aaacttacaa ttggcactaa agaatacatt taattatttc ctatgttagc   1380

tgttaaagaa acagcaggac ttgtttacaa agatgtcttc attcccaagg ttactggata   1440

gaagccaacc acagtctata ccatagcaat gtttttcctt taatccagtg ttactgtgtt   1500

tatcttgata aactaggaat tttgtcactg gagttttgga ctggataagt gctaccttaa   1560

agggtatact aagtgataca gtactttgaa tctagttgtt agattctcaa aattcctaca   1620

ctcttgacta gtgcaatttg gttcttgaaa attaaattta aacttgttta caaaggttta   1680

gttttgtaat aaggtgacta atttatctat agctgctata gcaagctatt ataaaacttg   1740

aatttctaca aatggtgaaa tttaatgttt tttaaactag tttatttgcc ttgccataac   1800

acatttttta actaataagg cttagatgaa catggtgttc aacctgtgct ctaaacagtg   1860

ggagtaccaa agaaattata aacaagataa atgctgtggc tccttcctaa ctggggcttt   1920

cttgacatgt aggttgcttg gtaataacct ttttgtatat cacaatttgg gtgaaaaact   1980

taagtaccct ttcaaactat ttatatgagg aagtcacttt actactctaa gatatcccta   2040

aggaattttt ttttttaatt tagtgtgact aaggctttat ttatgtttgt gaaactgtta   2100

aggtcctttc taaattcctc cattgtgaga taaggacagt gtcaaagtga taaagcttaa   2160

cacttgacct aaacttctat tttcttaagg aagaagagta ttaaatatat actgactcct   2220

agaaatctat ttattaaaaa aagacatgaa aacttgctgt acataggcta gctatttcta   2280

aatattttaa attagctttt ctaaaaaaaa aatccagcct cataaagtag attagaaaac   2340

tagattgcta gtttattttg ttatcagata tgtgaatctc ttctcccttt gaagaaacta   2400

tacatttatt gttacggtat gaagtcttct gtatagtttg tttttaaact aatatttgtt   2460

tcagtatttt gtctgaaaag aaaacaccac taattgtgta catatgtatt atataaactt   2520

aaccttttaa tactgtttat ttttagccca ttgtttaaaa aataaaagtt aaaaaaattt   2580

aactgcttaa aagtaaaaaa aaaaaaaaaa aaa                                2613


<210>  2318
<211>  359
<212>  PRT
<213>  Homosapiens

<400>  2318

Met Ser Arg Arg Ser Ser Arg Leu Gln Ala Lys Gln Gln Pro Gln Pro 
1               5                   10                  15      


Ser Gln Thr Glu Ser Pro Gln Glu Ala Gln Ile Ile Gln Ala Lys Lys 
            20                  25                  30          


Arg Lys Thr Thr Gln Asp Val Lys Lys Arg Arg Glu Glu Val Thr Lys 
        35                  40                  45              


Lys His Gln Tyr Glu Ile Arg Asn Cys Trp Pro Pro Val Leu Ser Gly 
    50                  55                  60                  


Gly Ile Ser Pro Cys Ile Ile Ile Glu Thr Pro His Lys Glu Ile Gly 
65                  70                  75                  80  


Thr Ser Asp Phe Ser Arg Phe Thr Asn Tyr Arg Phe Lys Asn Leu Phe 
                85                  90                  95      


Ile Asn Pro Ser Pro Leu Pro Asp Leu Ser Trp Gly Cys Ser Lys Glu 
            100                 105                 110         


Val Trp Leu Asn Met Leu Lys Lys Glu Ser Arg Tyr Val His Asp Lys 
        115                 120                 125             


His Phe Glu Val Leu His Ser Asp Leu Glu Pro Gln Met Arg Ser Ile 
    130                 135                 140                 


Leu Leu Asp Trp Leu Leu Glu Val Cys Glu Val Tyr Thr Leu His Arg 
145                 150                 155                 160 


Glu Thr Phe Tyr Leu Ala Tyr Val Thr Asp Gly Ala Cys Ser Glu Glu 
                165                 170                 175     


Asp Ile Leu Arg Met Glu Leu Ile Ile Leu Lys Ala Leu Lys Trp Glu 
            180                 185                 190         


Leu Cys Pro Val Thr Ile Ile Ser Trp Leu Asn Leu Phe Leu Gln Val 
        195                 200                 205             


Asp Ala Leu Lys Asp Ala Pro Lys Val Leu Leu Pro Gln Tyr Ser Gln 
    210                 215                 220                 


Glu Thr Phe Ile Gln Ile Ala Gln Leu Leu Asp Leu Cys Ile Leu Ala 
225                 230                 235                 240 


Ile Asp Ser Leu Glu Phe Gln Tyr Arg Ile Leu Thr Ala Ala Ala Leu 
                245                 250                 255     


Cys His Phe Thr Ser Ile Glu Val Val Lys Lys Ala Ser Gly Leu Glu 
            260                 265                 270         


Trp Asp Ser Ile Ser Glu Cys Val Asp Trp Met Val Pro Phe Val Asn 
        275                 280                 285             


Val Val Lys Ser Thr Ser Pro Val Lys Leu Lys Thr Phe Lys Lys Ile 
    290                 295                 300                 


Pro Met Glu Asp Arg His Asn Ile Gln Thr His Thr Asn Tyr Leu Ala 
305                 310                 315                 320 


Met Leu Glu Glu Val Asn Tyr Ile Asn Thr Phe Arg Lys Gly Gly Gln 
                325                 330                 335     


Leu Ser Pro Val Cys Asn Gly Gly Ile Met Thr Pro Pro Lys Ser Thr 
            340                 345                 350         


Glu Lys Pro Pro Gly Lys His 
        355                 


<210>  2319
<211>  2748
<212>  DNA
<213>  Homosapiens

<400>  2319
agcgggtgcg gggcgggacc ggcccggcct atatattggg ttggcgccgg cgccagctga     60

gccgagcggt agctggtctg gcgaggtttt atacacctga aagaagagaa tgtcaagacg    120

aagtagccgt ttacaagcta agcagcagcc ccagcccagc cagacggaat ccccccaaga    180

agcccagata atccaggcca agaagaggaa aactacccag gatgtcaaaa aaagaagaga    240

ggaggtcacc aagaaacatc agtatgaaat taggaattgt tggccacctg tattatctgg    300

ggggatcagt ccttgcatta tcattgaaac acctcacaaa gaaataggaa caagtgattt    360

ctccagattt acaaattaca gatttaaaaa tctttttatt aatccttcac ctttgcctga    420

tttaagctgg ggatgttcaa aagaagtctg gctaaacatg ttaaaaaagg agagcagata    480

tgttcatgac aaacattttg aagttctgca ttctgacttg gaaccacaga tgaggtccat    540

acttctagac tggcttttag aggtatgtga agtatacaca cttcataggg aaacatttta    600

tcttgcacaa gacttttttg atagatttat gttgacacaa aaggatataa ataaaaatat    660

gcttcaactc attggaatta cctcattatt cattgcttcc aaacttgagg aaatctatgc    720

tcctaaactc caagagtttg cttacgtcac tgatggtgct tgcagtgaag aggatatctt    780

aaggatggaa ctcattatat taaaggcttt aaaatgggaa ctttgtcctg taacaatcat    840

ctcctggcta aatctctttc tccaagttga tgctcttaaa gatgctccta aagttcttct    900

acctcagtat tctcaggaaa cattcattca aatagctcag cttttagatc tgtgtattct    960

agccattgat tcattagagt tccagtacag aatactgact gctgctgcct tgtgccattt   1020

tacctccatt gaagtggtta agaaagcctc aggtttggag tgggacagta tttcagaatg   1080

tgtagattgg atggtacctt ttgtcaatgt agtaaaaagt actagtccag tgaagctgaa   1140

gacttttaag aagattccta tggaagacag acataatatc cagacacata caaactattt   1200

ggctatgctg gaggaagtaa attacataaa caccttcaga aaagggggac agttgtcacc   1260

agtgtgcaat ggaggcatta tgacaccacc gaagagcact gaaaaaccac caggaaaaca   1320

ctaaagaaga taactaagca aacaagttgg aattcaccaa gattgggtag aactggtatc   1380

actgaactac taaagtttta cagaaagtag tgctgtgatt gattgcccta gccaattcac   1440

aagttacact gccattctga ttttaaaact tacaattggc actaaagaat acatttaatt   1500

atttcctatg ttagctgtta aagaaacagc aggacttgtt tacaaagatg tcttcattcc   1560

caaggttact ggatagaagc caaccacagt ctataccata gcaatgtttt tcctttaatc   1620

cagtgttact gtgtttatct tgataaacta ggaattttgt cactggagtt ttggactgga   1680

taagtgctac cttaaagggt atactaagtg atacagtact ttgaatctag ttgttagatt   1740

ctcaaaattc ctacactctt gactagtgca atttggttct tgaaaattaa atttaaactt   1800

gtttacaaag gtttagtttt gtaataaggt gactaattta tctatagctg ctatagcaag   1860

ctattataaa acttgaattt ctacaaatgg tgaaatttaa tgttttttaa actagtttat   1920

ttgccttgcc ataacacatt ttttaactaa taaggcttag atgaacatgg tgttcaacct   1980

gtgctctaaa cagtgggagt accaaagaaa ttataaacaa gataaatgct gtggctcctt   2040

cctaactggg gctttcttga catgtaggtt gcttggtaat aacctttttg tatatcacaa   2100

tttgggtgaa aaacttaagt accctttcaa actatttata tgaggaagtc actttactac   2160

tctaagatat ccctaaggaa tttttttttt taatttagtg tgactaaggc tttatttatg   2220

tttgtgaaac tgttaaggtc ctttctaaat tcctccattg tgagataagg acagtgtcaa   2280

agtgataaag cttaacactt gacctaaact tctattttct taaggaagaa gagtattaaa   2340

tatatactga ctcctagaaa tctatttatt aaaaaaagac atgaaaactt gctgtacata   2400

ggctagctat ttctaaatat tttaaattag cttttctaaa aaaaaaatcc agcctcataa   2460

agtagattag aaaactagat tgctagttta ttttgttatc agatatgtga atctcttctc   2520

cctttgaaga aactatacat ttattgttac ggtatgaagt cttctgtata gtttgttttt   2580

aaactaatat ttgtttcagt attttgtctg aaaagaaaac accactaatt gtgtacatat   2640

gtattatata aacttaacct tttaatactg tttattttta gcccattgtt taaaaaataa   2700

aagttaaaaa aatttaactg cttaaaagta aaaaaaaaaa aaaaaaaa                2748


<210>  2320
<211>  404
<212>  PRT
<213>  Homosapiens

<400>  2320

Met Ser Arg Arg Ser Ser Arg Leu Gln Ala Lys Gln Gln Pro Gln Pro 
1               5                   10                  15      


Ser Gln Thr Glu Ser Pro Gln Glu Ala Gln Ile Ile Gln Ala Lys Lys 
            20                  25                  30          


Arg Lys Thr Thr Gln Asp Val Lys Lys Arg Arg Glu Glu Val Thr Lys 
        35                  40                  45              


Lys His Gln Tyr Glu Ile Arg Asn Cys Trp Pro Pro Val Leu Ser Gly 
    50                  55                  60                  


Gly Ile Ser Pro Cys Ile Ile Ile Glu Thr Pro His Lys Glu Ile Gly 
65                  70                  75                  80  


Thr Ser Asp Phe Ser Arg Phe Thr Asn Tyr Arg Phe Lys Asn Leu Phe 
                85                  90                  95      


Ile Asn Pro Ser Pro Leu Pro Asp Leu Ser Trp Gly Cys Ser Lys Glu 
            100                 105                 110         


Val Trp Leu Asn Met Leu Lys Lys Glu Ser Arg Tyr Val His Asp Lys 
        115                 120                 125             


His Phe Glu Val Leu His Ser Asp Leu Glu Pro Gln Met Arg Ser Ile 
    130                 135                 140                 


Leu Leu Asp Trp Leu Leu Glu Val Cys Glu Val Tyr Thr Leu His Arg 
145                 150                 155                 160 


Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg Phe Met Leu Thr 
                165                 170                 175     


Gln Lys Asp Ile Asn Lys Asn Met Leu Gln Leu Ile Gly Ile Thr Ser 
            180                 185                 190         


Leu Phe Ile Ala Ser Lys Leu Glu Glu Ile Tyr Ala Pro Lys Leu Gln 
        195                 200                 205             


Glu Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser Glu Glu Asp Ile Leu 
    210                 215                 220                 


Arg Met Glu Leu Ile Ile Leu Lys Ala Leu Lys Trp Glu Leu Cys Pro 
225                 230                 235                 240 


Val Thr Ile Ile Ser Trp Leu Asn Leu Phe Leu Gln Val Asp Ala Leu 
                245                 250                 255     


Lys Asp Ala Pro Lys Val Leu Leu Pro Gln Tyr Ser Gln Glu Thr Phe 
            260                 265                 270         


Ile Gln Ile Ala Gln Leu Leu Asp Leu Cys Ile Leu Ala Ile Asp Ser 
        275                 280                 285             


Leu Glu Phe Gln Tyr Arg Ile Leu Thr Ala Ala Ala Leu Cys His Phe 
    290                 295                 300                 


Thr Ser Ile Glu Val Val Lys Lys Ala Ser Gly Leu Glu Trp Asp Ser 
305                 310                 315                 320 


Ile Ser Glu Cys Val Asp Trp Met Val Pro Phe Val Asn Val Val Lys 
                325                 330                 335     


Ser Thr Ser Pro Val Lys Leu Lys Thr Phe Lys Lys Ile Pro Met Glu 
            340                 345                 350         


Asp Arg His Asn Ile Gln Thr His Thr Asn Tyr Leu Ala Met Leu Glu 
        355                 360                 365             


Glu Val Asn Tyr Ile Asn Thr Phe Arg Lys Gly Gly Gln Leu Ser Pro 
    370                 375                 380                 


Val Cys Asn Gly Gly Ile Met Thr Pro Pro Lys Ser Thr Glu Lys Pro 
385                 390                 395                 400 


Pro Gly Lys His 
                


<210>  2321
<211>  3716
<212>  DNA
<213>  Homosapiens

<400>  2321
cccgaggagc cgggccccgg ccgctgtcca gccgctccgt gccccgcgcg tcctgcgccg     60

ccgccaccgc ctcctgggga gacgcagcca cttgcccgcc atggatactc ccagggtcct    120

gctctcggcc gtcttcctca tcagttttct gtgggatttg cccggtttcc agcaggcttc    180

catctcatcc tcctcgtcgt ccgccgagct gggttccacc aagggcatgc gaagccgcaa    240

ggaaggcaag atgcagcggg cgccgcgcga cagtgacgcg ggccgggagg gccaggaacc    300

acagccgcgg cctcaggacg aaccccgggc tcagcagccc cgggcgcagg agccgccagg    360

caggggtccg cgcgtggtgc cccacgagta catgctgtca atctacagga cttactccat    420

cgctgagaag ctgggcatca atgccagctt tttccagtct tccaagtcgg ctaatacgat    480

caccagcttt gtagacaggg gactagacga tctctcgcac actcctctcc ggagacagaa    540

gtatttgttt gatgtgtcca tgctctcaga caaagaagag ctggtgggcg cggagctgcg    600

gctctttcgc caggcgccct cagcgccctg ggggccacca gccgggccgc tccacgtgca    660

gctcttccct tgcctttcgc ccctactgct ggacgcgcgg accctggacc cgcagggggc    720

gccgccggcc ggctgggaag tcttcgacgt gtggcagggc ctgcgccacc agccctggaa    780

gcagctgtgc ttggagctgc gggccgcatg gggcgagctg gacgccgggg aggccgaggc    840

gcgcgcgcgg ggaccccagc aaccgccgcc cccggacctg cggagtctgg gcttcggccg    900

gagggtgcgg cctccccagg agcgggccct gctggtggta ttcaccagat cccagcgcaa    960

gaacctgttc gcagagatgc gcgagcagct gggctcggcc gaggctgcgg gcccgggcgc   1020

gggcgccgag gggtcgtggc cgccgccgtc gggcgccccg gatgccaggc cttggctgcc   1080

ctcgcccggc cgccggcggc ggcgcacggc cttcgccagt cgccatggca agcggcacgg   1140

caagaagtcc aggctacgct gcagcaagaa gcccctgcac gtgaacttca aggagctggg   1200

ctgggacgac tggattatcg cgcccctgga gtacgaggcc tatcactgcg agggtgtatg   1260

cgacttcccg ctgcgctcgc acctggagcc caccaaccac gccatcatcc agacgctgat   1320

gaactccatg gaccccggct ccaccccgcc cagctgctgc gtgcccacca aattgactcc   1380

catcagcatt ctatacatcg acgcgggcaa taatgtggtc tacaagcagt acgaggacat   1440

ggtggtggag tcgtgcggct gcaggtagcg gtgcctttcc cgccgccttg gcccggaacc   1500

aaggtgggcc aaggtccgcc ttgcagggga ggcctggctg cagagaggcg gaggaggaag   1560

ctggcgctgg gggaggctga gggtgaggga acagcctgga tgtgagagcc ggtgggagag   1620

aagggagcgc agccttccca gtaacttcta cctgccagcc cagagggaaa tatggatttt   1680

cacaccttgc ctggccaccc tggaaaaaca agccaaggag gatttctttt gttctgtttt   1740

ctctctctct ctctctctct ctctctctct ctctctctct ctctctatta ctgtggcttt   1800

ggatttcctt atgtgtctta caggctttga tagaagggga ggggaggaga gatgcatacc   1860

cgtttctcaa ctgctccatg gattgaaaaa ataacagttt aaaaagggaa acaatgtggg   1920

aggaagaatc accgttgacg catcttgatt tggttggttt ttacatgtgt aaagaaggtg   1980

gggtctctgg ccatgtcata gcccatgtct tgtgccctcc cacacagaaa gtgttagata   2040

gggaaattgg caaaaagaat agttaagtca ggaatggtcc tgcctataga agagctttga   2100

gagaggtggg cccacgggtg cccctctcac ccatttgtgt actctgtgag tttaccagct   2160

ctgccctggc ctctttcggt accaggaact ggcaaccttc atctcactcc tgagggccca   2220

ggtctctgcc ttcattgttg ctttttctgg tgggggcaag gggagctggt atggatggaa   2280

tgacaagaat tagtccaaat ggaacccctt gaaggataat gagaaaccac aaggcctgcc   2340

tctgactggg gctgacacgg aggtgcatta gcccaggctg gaggtagccc acccaaatgc   2400

cctttctgat tctaattgat ttctttcaac agaatttgcc aaaattcaga catgcacttc   2460

taaggggaag gtgattttcc agttcaaaaa aatgggcagg agtggggaac aaaacaatta   2520

acgtaagagc tacaaaggag ggaaaaggaa ccaagaagta gaaggagtcc catcaggagg   2580

gaagatggtg ggcctcaggg aggatgggga tcaagggaca ggccaggagc caggagtggg   2640

gaagggaggg atgaaagggg acacaagtcc ctgtctctga agtttcttta aaatctgagt   2700

tccctcccct ctctttgaca ttcctgaaag attaccagcc agcaatagcc cagggctccc   2760

ccaaaagaat tggttcagat tgtaattatc agttaggcaa tgtttttaaa acttagtaat   2820

gagaaactgt gaaaagagcc aagtgttaca ttgagcttgg ggtgggagat ggggaacagg   2880

cagtgaggaa ggagacaggg gtggaattcg tcttctggga ggaagctgga gagagcacag   2940

tgaaattgaa atacccattc ccagatagtc aaaaacatga actttccccc agcctgcacc   3000

agtattgttt tcaaacattg cccatgagta ggccctttga agagttagct tcctcctcat   3060

ctttgactat aaaattgttt aatcaatgga atttgtacca gccttttaaa aagttttagt   3120

ttttcctaag tgattttgct ctcttccaat ctaaacctgt tgcttgtttg gttcagagaa   3180

ctacaaactg tcaaagaaag ggtggggatg ataagaaatg ctaatataaa aatgctaagt   3240

gaaaaaaaga cttggccagg agaaataatt taaaatgcac atttgctttg gatgcactgt   3300

tgttctgtta aggctgtata tatttgttta tttaaggtga ctgaaagtgc aaagaggaaa   3360

tggacagcat gcaattcatc ctaatgtaca aaacgttata tgcactcaaa tgttataatt   3420

tctaatattt ttaaagttta tattcgagtt gtacaaagtt aagcattaat cagatatttc   3480

attttttcat aatgttacca ttttcttaaa tattattaca aaattttaag tctgtctaat   3540

ggagagtttt ttttaaactg tctacctcat ataatacaag tatttacaac gctaaagtta   3600

ccagaggtca atgaataatc aaaacatttt ttacagtaca cctttcctgg atgatatgca   3660

atcgaatgct atattattaa acgcattttt ctccttatta aaaaaaaaaa aaaaaa       3716


<210>  2322
<211>  455
<212>  PRT
<213>  Homosapiens

<400>  2322

Met Asp Thr Pro Arg Val Leu Leu Ser Ala Val Phe Leu Ile Ser Phe 
1               5                   10                  15      


Leu Trp Asp Leu Pro Gly Phe Gln Gln Ala Ser Ile Ser Ser Ser Ser 
            20                  25                  30          


Ser Ser Ala Glu Leu Gly Ser Thr Lys Gly Met Arg Ser Arg Lys Glu 
        35                  40                  45              


Gly Lys Met Gln Arg Ala Pro Arg Asp Ser Asp Ala Gly Arg Glu Gly 
    50                  55                  60                  


Gln Glu Pro Gln Pro Arg Pro Gln Asp Glu Pro Arg Ala Gln Gln Pro 
65                  70                  75                  80  


Arg Ala Gln Glu Pro Pro Gly Arg Gly Pro Arg Val Val Pro His Glu 
                85                  90                  95      


Tyr Met Leu Ser Ile Tyr Arg Thr Tyr Ser Ile Ala Glu Lys Leu Gly 
            100                 105                 110         


Ile Asn Ala Ser Phe Phe Gln Ser Ser Lys Ser Ala Asn Thr Ile Thr 
        115                 120                 125             


Ser Phe Val Asp Arg Gly Leu Asp Asp Leu Ser His Thr Pro Leu Arg 
    130                 135                 140                 


Arg Gln Lys Tyr Leu Phe Asp Val Ser Met Leu Ser Asp Lys Glu Glu 
145                 150                 155                 160 


Leu Val Gly Ala Glu Leu Arg Leu Phe Arg Gln Ala Pro Ser Ala Pro 
                165                 170                 175     


Trp Gly Pro Pro Ala Gly Pro Leu His Val Gln Leu Phe Pro Cys Leu 
            180                 185                 190         


Ser Pro Leu Leu Leu Asp Ala Arg Thr Leu Asp Pro Gln Gly Ala Pro 
        195                 200                 205             


Pro Ala Gly Trp Glu Val Phe Asp Val Trp Gln Gly Leu Arg His Gln 
    210                 215                 220                 


Pro Trp Lys Gln Leu Cys Leu Glu Leu Arg Ala Ala Trp Gly Glu Leu 
225                 230                 235                 240 


Asp Ala Gly Glu Ala Glu Ala Arg Ala Arg Gly Pro Gln Gln Pro Pro 
                245                 250                 255     


Pro Pro Asp Leu Arg Ser Leu Gly Phe Gly Arg Arg Val Arg Pro Pro 
            260                 265                 270         


Gln Glu Arg Ala Leu Leu Val Val Phe Thr Arg Ser Gln Arg Lys Asn 
        275                 280                 285             


Leu Phe Ala Glu Met Arg Glu Gln Leu Gly Ser Ala Glu Ala Ala Gly 
    290                 295                 300                 


Pro Gly Ala Gly Ala Glu Gly Ser Trp Pro Pro Pro Ser Gly Ala Pro 
305                 310                 315                 320 


Asp Ala Arg Pro Trp Leu Pro Ser Pro Gly Arg Arg Arg Arg Arg Thr 
                325                 330                 335     


Ala Phe Ala Ser Arg His Gly Lys Arg His Gly Lys Lys Ser Arg Leu 
            340                 345                 350         


Arg Cys Ser Lys Lys Pro Leu His Val Asn Phe Lys Glu Leu Gly Trp 
        355                 360                 365             


Asp Asp Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Tyr His Cys Glu 
    370                 375                 380                 


Gly Val Cys Asp Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn His 
385                 390                 395                 400 


Ala Ile Ile Gln Thr Leu Met Asn Ser Met Asp Pro Gly Ser Thr Pro 
                405                 410                 415     


Pro Ser Cys Cys Val Pro Thr Lys Leu Thr Pro Ile Ser Ile Leu Tyr 
            420                 425                 430         


Ile Asp Ala Gly Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met Val 
        435                 440                 445             


Val Glu Ser Cys Gly Cys Arg 
    450                 455 


<210>  2323
<211>  965
<212>  DNA
<213>  Homosapiens

<400>  2323
cagcttgtcc tctatgactt acccagaagg caacgcttct ctttctggtc aaaatggctg     60

gtaagcaggc cgtttcagca tcaggcaagt ggctggatgg tattcgaaaa tggtattaca    120

atgctgcagg attcaataaa ctggggttaa tgcgagatga tacaatatac gaggatgaag    180

atgtaaaaga agccataaga agacttcctg agaaccttta taatgacagg atgtttcgca    240

ttaagagggc actggacctg aacttgaagc atcagatctt gcctaaagag cagtggacca    300

aatatgaaga ggaaaatttc taccttgaac cgtatctgaa agaggttatt cgggaaagaa    360

aagaaagaga agaatgggca aagaagtaat catgtagttg aagtctgtgg atgcagctgt    420

tatgaagatg gttaaacttg aaacaaacaa ttttaagaat tatttggtct gaagatgttt    480

tactttaaat aaatgtctat tgtaatggct ggagtttttg aattccaaac cttatactga    540

ataactactg aatcccttta ctgttaaatt tttttccaaa ctttcaagat atatttagtt    600

gtgtttaact gctacttgga gctcagaagc cactttatca gttttcctca ctggttggat    660

agcctatcag tttatggaag gatataactt ccgtaagtta catccttatg gaagctactg    720

aataaaagaa gggggtatgc accccctagt ttgccaagat tgagaaatag cctcttcact    780

ggtatgcaaa cagatttgat tttgcatcct atcatttaaa aagaaattat gtctgcaccc    840

caacataggc atacttaagt aatatacata ctcctgtgct aacatgtata ctagaaaaca    900

aaaagatgtt agaaaaataa aagtataaag acaaatcaaa aaaaaaaaaa aaaaaaaaaa    960

aaaaa                                                                965


<210>  2324
<211>  111
<212>  PRT
<213>  Homosapiens

<400>  2324

Met Ala Gly Lys Gln Ala Val Ser Ala Ser Gly Lys Trp Leu Asp Gly 
1               5                   10                  15      


Ile Arg Lys Trp Tyr Tyr Asn Ala Ala Gly Phe Asn Lys Leu Gly Leu 
            20                  25                  30          


Met Arg Asp Asp Thr Ile Tyr Glu Asp Glu Asp Val Lys Glu Ala Ile 
        35                  40                  45              


Arg Arg Leu Pro Glu Asn Leu Tyr Asn Asp Arg Met Phe Arg Ile Lys 
    50                  55                  60                  


Arg Ala Leu Asp Leu Asn Leu Lys His Gln Ile Leu Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Thr Lys Tyr Glu Glu Glu Asn Phe Tyr Leu Glu Pro Tyr Leu Lys 
                85                  90                  95      


Glu Val Ile Arg Glu Arg Lys Glu Arg Glu Glu Trp Ala Lys Lys 
            100                 105                 110     


<210>  2325
<211>  1424
<212>  DNA
<213>  Homosapiens

<400>  2325
gggacgtgcg gcccagcgag ttggtcggtc ccggggtcac ccgctacggg aagcaggcct     60

cgccacagac taagaaaaat ggctttgtca gcccaacaga tacccagatg gtttaactca    120

gttaagttga ggagcctcat taatgctgca caactcacaa aacgttttac tagaccagca    180

agaacactgt tacatggctt ttctgctcag cctcagatat cctctgacaa ttgctttctc    240

cagtggggat ttaagactta caggacttcc tccttatgga atagttccca gtctactagc    300

tcaagtagtc aggagaataa ttctgcccaa agcagtctgc ttccttccat gaatgaacag    360

tcacagaaga cacaaaatat atccagcttt gattctgagc tgtttctaga agaactggat    420

gaattgcctc cattgtctcc aatgcagcca atttcagagg aagaggctat tcagattatt    480

gcagaccctc cattgccacc agcttcattc acacttcgag actatgtgga tcattctgag    540

actctgcaga agttggttct tctaggcgtg gatttgtcca agatagaaaa acatccagaa    600

gcagcaaacc tccttctgag actggatttt gaaaaagaca ttaagcaaat gcttctgttt    660

cttaaagatg tgggtataga ggataaccaa ctgggagcat tcctgacaaa aaatcatgca    720

attttctctg aagaccttga aaatctgaag accagggtgg cttatctgca ttcaaaaaat    780

ttcagtaaag cagatgttgc acagatggtc agaaaagcac catttttgct gaacttttca    840

gtggaaagac tggataacag attgggattt tttcagaaag aacttgaact tagtgtgaag    900

aagactagag atctggtagt tcgtctccca aggctgctaa ctggaagtct ggaacccgtg    960

aaagaaaata tgaaggttta tcgtcttgaa cttggtttta aacataacga aattcaacat   1020

atgatcacca gaatcccaaa gatgttaact gcaaataaaa tgaaacttac cgagacgttt   1080

gattttgtgc acaatgtgat gagcattccc caccacatca ttgtcaagtt cccacaggta   1140

tttaatacaa ggctgtttaa ggtcaaagaa agacacttgt ttcttaccta tttaggaaga   1200

gcacagtatg atccagcaaa acctaactac atctctttgg acaaactagt atctattcct   1260

gatgaaatat tttgtgaaga gattgccaaa gcatcagtac aggactttga aaaattctta   1320

aaaacgcttt agatttttat gtatgttaaa atgcagtatt gtaaagtgaa tatatatatg   1380

aataaatgaa tatattttta aatgccaaaa aaaaaaaaaa aaaa                    1424


<210>  2326
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  2326

Met Ala Leu Ser Ala Gln Gln Ile Pro Arg Trp Phe Asn Ser Val Lys 
1               5                   10                  15      


Leu Arg Ser Leu Ile Asn Ala Ala Gln Leu Thr Lys Arg Phe Thr Arg 
            20                  25                  30          


Pro Ala Arg Thr Leu Leu His Gly Phe Ser Ala Gln Pro Gln Ile Ser 
        35                  40                  45              


Ser Asp Asn Cys Phe Leu Gln Trp Gly Phe Lys Thr Tyr Arg Thr Ser 
    50                  55                  60                  


Ser Leu Trp Asn Ser Ser Gln Ser Thr Ser Ser Ser Ser Gln Glu Asn 
65                  70                  75                  80  


Asn Ser Ala Gln Ser Ser Leu Leu Pro Ser Met Asn Glu Gln Ser Gln 
                85                  90                  95      


Lys Thr Gln Asn Ile Ser Ser Phe Asp Ser Glu Leu Phe Leu Glu Glu 
            100                 105                 110         


Leu Asp Glu Leu Pro Pro Leu Ser Pro Met Gln Pro Ile Ser Glu Glu 
        115                 120                 125             


Glu Ala Ile Gln Ile Ile Ala Asp Pro Pro Leu Pro Pro Ala Ser Phe 
    130                 135                 140                 


Thr Leu Arg Asp Tyr Val Asp His Ser Glu Thr Leu Gln Lys Leu Val 
145                 150                 155                 160 


Leu Leu Gly Val Asp Leu Ser Lys Ile Glu Lys His Pro Glu Ala Ala 
                165                 170                 175     


Asn Leu Leu Leu Arg Leu Asp Phe Glu Lys Asp Ile Lys Gln Met Leu 
            180                 185                 190         


Leu Phe Leu Lys Asp Val Gly Ile Glu Asp Asn Gln Leu Gly Ala Phe 
        195                 200                 205             


Leu Thr Lys Asn His Ala Ile Phe Ser Glu Asp Leu Glu Asn Leu Lys 
    210                 215                 220                 


Thr Arg Val Ala Tyr Leu His Ser Lys Asn Phe Ser Lys Ala Asp Val 
225                 230                 235                 240 


Ala Gln Met Val Arg Lys Ala Pro Phe Leu Leu Asn Phe Ser Val Glu 
                245                 250                 255     


Arg Leu Asp Asn Arg Leu Gly Phe Phe Gln Lys Glu Leu Glu Leu Ser 
            260                 265                 270         


Val Lys Lys Thr Arg Asp Leu Val Val Arg Leu Pro Arg Leu Leu Thr 
        275                 280                 285             


Gly Ser Leu Glu Pro Val Lys Glu Asn Met Lys Val Tyr Arg Leu Glu 
    290                 295                 300                 


Leu Gly Phe Lys His Asn Glu Ile Gln His Met Ile Thr Arg Ile Pro 
305                 310                 315                 320 


Lys Met Leu Thr Ala Asn Lys Met Lys Leu Thr Glu Thr Phe Asp Phe 
                325                 330                 335     


Val His Asn Val Met Ser Ile Pro His His Ile Ile Val Lys Phe Pro 
            340                 345                 350         


Gln Val Phe Asn Thr Arg Leu Phe Lys Val Lys Glu Arg His Leu Phe 
        355                 360                 365             


Leu Thr Tyr Leu Gly Arg Ala Gln Tyr Asp Pro Ala Lys Pro Asn Tyr 
    370                 375                 380                 


Ile Ser Leu Asp Lys Leu Val Ser Ile Pro Asp Glu Ile Phe Cys Glu 
385                 390                 395                 400 


Glu Ile Ala Lys Ala Ser Val Gln Asp Phe Glu Lys Phe Leu Lys Thr 
                405                 410                 415     


Leu 
    


<210>  2327
<211>  3729
<212>  DNA
<213>  Homosapiens

<400>  2327
ggcccaagcc gccattgttc cgccgaggga ggacagcggg gcctggcgct ggcgccgaga     60

cgccgcttag cggccgccac tggagacact ccctcccgcc tcccgggtct cctggcggcg    120

gcggagtgag gctgacagcg gggaacctgg gagacccctc cgccctcccc gcggtggcag    180

cggccgatcc ccggctccgg cgcgagggac ggccgcgatg cgctcggcct gaggttaccc    240

ggcccggccc ttcctcgctt ccctcgacta ttccactgcg tctccgcgcc ccggcgtcat    300

cctgcgagtc cctctgacgg gagggaagat ggctgcacgg agctggcagg acgagctggc    360

ccagcaggcc gaggagggct cggcccggct gcgggaaatg ctctcggtcg gcctaggctt    420

tctgcgcacc gagctgggcc tcgacctggg gctggagccg aaacggtacc ccggctgggt    480

gatcctggtg ggcactggcg cgctcgggct gctgctgctg tttctgctgg gctacggctg    540

ggccgcggct tgcgccggct cccgcaaaaa gcggaggagc ccgccccgca agcgggagga    600

ggcggcggcc gtgccggccg cggcccccga cgacctggcc ttgctgaaga atctccggag    660

cgaggaacag aagaagaaga accggaagaa actgtccgag aagcccaaac caaatgggcg    720

gactgttgaa gtggctgagg gtgaagctgt tcgaacacct caaagtgtaa cagcaaagca    780

gccaccagag attgacaaga aaaatgaaaa gtcaaagaaa aataagaaga aatcaaagtc    840

agatgctaaa gcagtgcaaa acagttcacg ccatgatgga aaggaagttg atgaaggagc    900

ctgggaaact aaaattagtc acagagagaa acgacagcag cgtaaacgtg ataaggtgct    960

gactgattct ggttcattgg attcaactat ccctgggata gaaaatacca tcacagttac   1020

caccgagcaa cttacaaccg catcatttcc tgttggttcc aagaagaata aaggtgattc   1080

tcatctaaat gttcaagtta gcaactttaa atctggaaaa ggagattcta cacttcaggt   1140

ttcttcagga ttgaatgaaa acctcactgt caatggagga ggctggaatg aaaagtctgt   1200

aaaactctcc tcacagatca gtgcaggtga ggagaagtgg aactccgttt cacctgcttc   1260

tgcaggaaag aggaaagctg agccatctgc ctggagtcaa gacactggag atgctaatac   1320

aaatggaaaa gactggggaa ggagttggag tgaccgttca atattttctg gcattgggtc   1380

tactgctgag ccagtttctc agtctaccac ttctgattat cagtgggatg ttagccgtaa   1440

tcaaccctat atcgatgatg aatggtctgg gttaaatggt ctgtcttctg ctgatcccaa   1500

ctctgattgg aatgcaccag cagaagagtg gggcaattgg gtagacgaag aaagagcttc   1560

acttctaaag tcccaggaac caattcctga tgatcaaaag gtctcagatg atgataaaga   1620

aaagggagag ggagctcttc caactgggaa atccaaaaag aaaaaaaaga aaaagaagaa   1680

gcaaggtgaa gataactcta ctgcacagga cacagaagaa ttagaaaaag agattagaga   1740

agaccttcca gtgaatacct ctaaaacccg tccaaaacag gaaaaagctt tttccttgaa   1800

gaccataagc actagtgatc cagccgaagt actcgtcaaa aatagccagc ctatcaagac   1860

tcttccacct gctacttcta ccgagccatc tgtaatctta tcaaaaagtg attctgacaa   1920

gagctcttcc caagtgccgc caatactaca agagacagat aaatccaagt caaataccaa   1980

gcaaaatagt gtgcctcctt cacagaccaa gtctgaaact agctgggaat ctcccaaaca   2040

aataaaaaag aagaaaaaag ccagacgaga aacgtgaaat tttttttcct gaattggaca   2100

tgtgtttgca aacacttgtc ttgaagatta tgctgtttat gcaataattt gtgaacatgt   2160

acagagtttt atataaattt aaaccaattt ttaaaacaaa actgcggaca ccaccataaa   2220

aatggaatca aaagaaagtt aatttatgaa attaagaggt cagcagaata tactcagtga   2280

tggaagacac ttgggaaagt ctttttaata gaacaagaac gatcttaatt taagaatatt   2340

atcctggttt aacaacagtg ccctgtttac aacagattgt gccctatctc atctgcagcc   2400

gaggaataaa ggattctgat tagaaagagg gttgcctaca gattagtaag caattccttg   2460

gatcttatgc acagaacttg taccatttga atctgtttta tgcttaaatc aaagtgcttt   2520

gatcaaatgc ataacctgcc atatctttac atatttgttg gtagcaattt gtattaaaga   2580

aatcacaagt gcaaataaaa agtcatttat catttgttta actaaactgt catggtttag   2640

tttacaattt ttaaaaagtt cttaaaatac tgaaaatgca gttgacactt gtgtatggct   2700

tatgaagtta tttttgatag tcttacatta cttgaattgt tcaaagtaca gtatatttta   2760

aattaagaaa agtgaactat atgtatttgt tttatacatt taaggcttag actcataaat   2820

aatgctattg tttatgattt gaaaactttc aggcaaaatc caatttacat ttttcccttc   2880

cctagcaatt acttttttcc agcttcaact cttcttagtt actaatactt tgttgacttt   2940

aaaaatgaaa tcattcacaa acttttggta tatgatggag aatgaaaaac tagagtcaga   3000

cagctttaat tgacattgtc aacacctcca gttatcagga atacattttt ttactgcctt   3060

aacctgtagt gcgtagaata tgcatcaatt tcttgaagga gattcatgtt tttataagaa   3120

ttttcatgta attattgcaa ttgtggtcaa ataaggaacg tttcctgctt gaaattatat   3180

tgatttaaat gatgtgtgag atgtttcacc attttcaggc actgtgtaat tctattgtaa   3240

taaactggca ggtatctttg taactataaa tagtgcatgc tcagccatgt acactgtaaa   3300

tagcctttac caaacgtgtt tgacaaggac cataattaac atcacttagt gaattgtgat   3360

aaagaaaaaa aagccatgat ttattcgatg tgattggctt gtttttatgt ggcgccaaga   3420

acgaacctgt ttaacagctg taaccaatgg tactgatcta tccatccaat gttgtcatta   3480

tatttgactg tggttcaaca gtattgcgtt gtcagactag gaaagctaaa cgaacaaaat   3540

ggttttagtt ttgctgaaga ctggccttat taatggacag ctttcctaac aagagattat   3600

taacttttat caggtgttaa catctgtttc aggaacatgg cagtatgttt acatgtcaga   3660

agttttgttt aattctatgg tatttctaaa ttgacttgtt taaataaatt cagcaaaaaa   3720

aaaaaaaaa                                                           3729


<210>  2328
<211>  582
<212>  PRT
<213>  Homosapiens

<400>  2328

Met Ala Ala Arg Ser Trp Gln Asp Glu Leu Ala Gln Gln Ala Glu Glu 
1               5                   10                  15      


Gly Ser Ala Arg Leu Arg Glu Met Leu Ser Val Gly Leu Gly Phe Leu 
            20                  25                  30          


Arg Thr Glu Leu Gly Leu Asp Leu Gly Leu Glu Pro Lys Arg Tyr Pro 
        35                  40                  45              


Gly Trp Val Ile Leu Val Gly Thr Gly Ala Leu Gly Leu Leu Leu Leu 
    50                  55                  60                  


Phe Leu Leu Gly Tyr Gly Trp Ala Ala Ala Cys Ala Gly Ser Arg Lys 
65                  70                  75                  80  


Lys Arg Arg Ser Pro Pro Arg Lys Arg Glu Glu Ala Ala Ala Val Pro 
                85                  90                  95      


Ala Ala Ala Pro Asp Asp Leu Ala Leu Leu Lys Asn Leu Arg Ser Glu 
            100                 105                 110         


Glu Gln Lys Lys Lys Asn Arg Lys Lys Leu Ser Glu Lys Pro Lys Pro 
        115                 120                 125             


Asn Gly Arg Thr Val Glu Val Ala Glu Gly Glu Ala Val Arg Thr Pro 
    130                 135                 140                 


Gln Ser Val Thr Ala Lys Gln Pro Pro Glu Ile Asp Lys Lys Asn Glu 
145                 150                 155                 160 


Lys Ser Lys Lys Asn Lys Lys Lys Ser Lys Ser Asp Ala Lys Ala Val 
                165                 170                 175     


Gln Asn Ser Ser Arg His Asp Gly Lys Glu Val Asp Glu Gly Ala Trp 
            180                 185                 190         


Glu Thr Lys Ile Ser His Arg Glu Lys Arg Gln Gln Arg Lys Arg Asp 
        195                 200                 205             


Lys Val Leu Thr Asp Ser Gly Ser Leu Asp Ser Thr Ile Pro Gly Ile 
    210                 215                 220                 


Glu Asn Thr Ile Thr Val Thr Thr Glu Gln Leu Thr Thr Ala Ser Phe 
225                 230                 235                 240 


Pro Val Gly Ser Lys Lys Asn Lys Gly Asp Ser His Leu Asn Val Gln 
                245                 250                 255     


Val Ser Asn Phe Lys Ser Gly Lys Gly Asp Ser Thr Leu Gln Val Ser 
            260                 265                 270         


Ser Gly Leu Asn Glu Asn Leu Thr Val Asn Gly Gly Gly Trp Asn Glu 
        275                 280                 285             


Lys Ser Val Lys Leu Ser Ser Gln Ile Ser Ala Gly Glu Glu Lys Trp 
    290                 295                 300                 


Asn Ser Val Ser Pro Ala Ser Ala Gly Lys Arg Lys Ala Glu Pro Ser 
305                 310                 315                 320 


Ala Trp Ser Gln Asp Thr Gly Asp Ala Asn Thr Asn Gly Lys Asp Trp 
                325                 330                 335     


Gly Arg Ser Trp Ser Asp Arg Ser Ile Phe Ser Gly Ile Gly Ser Thr 
            340                 345                 350         


Ala Glu Pro Val Ser Gln Ser Thr Thr Ser Asp Tyr Gln Trp Asp Val 
        355                 360                 365             


Ser Arg Asn Gln Pro Tyr Ile Asp Asp Glu Trp Ser Gly Leu Asn Gly 
    370                 375                 380                 


Leu Ser Ser Ala Asp Pro Asn Ser Asp Trp Asn Ala Pro Ala Glu Glu 
385                 390                 395                 400 


Trp Gly Asn Trp Val Asp Glu Glu Arg Ala Ser Leu Leu Lys Ser Gln 
                405                 410                 415     


Glu Pro Ile Pro Asp Asp Gln Lys Val Ser Asp Asp Asp Lys Glu Lys 
            420                 425                 430         


Gly Glu Gly Ala Leu Pro Thr Gly Lys Ser Lys Lys Lys Lys Lys Lys 
        435                 440                 445             


Lys Lys Lys Gln Gly Glu Asp Asn Ser Thr Ala Gln Asp Thr Glu Glu 
    450                 455                 460                 


Leu Glu Lys Glu Ile Arg Glu Asp Leu Pro Val Asn Thr Ser Lys Thr 
465                 470                 475                 480 


Arg Pro Lys Gln Glu Lys Ala Phe Ser Leu Lys Thr Ile Ser Thr Ser 
                485                 490                 495     


Asp Pro Ala Glu Val Leu Val Lys Asn Ser Gln Pro Ile Lys Thr Leu 
            500                 505                 510         


Pro Pro Ala Thr Ser Thr Glu Pro Ser Val Ile Leu Ser Lys Ser Asp 
        515                 520                 525             


Ser Asp Lys Ser Ser Ser Gln Val Pro Pro Ile Leu Gln Glu Thr Asp 
    530                 535                 540                 


Lys Ser Lys Ser Asn Thr Lys Gln Asn Ser Val Pro Pro Ser Gln Thr 
545                 550                 555                 560 


Lys Ser Glu Thr Ser Trp Glu Ser Pro Lys Gln Ile Lys Lys Lys Lys 
                565                 570                 575     


Lys Ala Arg Arg Glu Thr 
            580         


<210>  2329
<211>  2242
<212>  DNA
<213>  Homosapiens

<400>  2329
gaatctcgac ccttgaatgg agttacacga acggccagat gaaagaagga aggcccggac     60

ctccactcag ggccgactag gggactggcg gagggtgcac gctgatggat ttactcaccg    120

ggtgcttgga gctccagcag ctggctggag cccgcgatga cgtcacggac tcgggtcaca    180

tggccaagtc cgccccgccc cctccccgtc cccgccgctg cagcggtcgc cttcggagcg    240

aagggtaccg acccggcaga agctcggagc tctcggggta tcgaggaggc aggcccgcgg    300

gcgcacgggc gagcgggccg ggagccggag cggcggagga gccggcagca gcggcgcggc    360

gggctccagg cgaggcggtc gacgctcctg aaaacttgcg cgcgcgctcg cgccactgcg    420

cccggagcga tgaagatggt cgcgccctgg acgcggttct actccaacag ctgctgcttg    480

tgctgccatg tccgcaccgg caccatcctg ctcggcgtct ggtatctgat catcaatgct    540

gtggtactgt tgattttatt gagtgccctg gctgatccgg atcagtataa cttttcaagt    600

tctgaactgg gaggtgactt tgagttcatg gatgatgcca acatgtgcat tgccattgcg    660

atttctcttc tcatgatcct gatatgtgct atggctactt acggagcgta caagcaacgc    720

gcagcctgga tcatcccatt cttctgttac cagatctttg actttgccct gaacatgttg    780

gttgcaatca ctgtgcttat ttatccaaac tccattcagg aatacatacg gcaactgcct    840

cctaattttc cctacagaga tgatgtcatg tcagtgaatc ctacctgttt ggtccttatt    900

attcttctgt ttattagcat tatcttgact tttaagggtt acttgattag ctgtgtttgg    960

aactgctacc gatacatcaa tggtaggaac tcctctgatg tcctggttta tgttaccagc   1020

aatgacacta cggtgctgct acccccgtat gatgatgcca ctgtgaatgg tgctgccaag   1080

gagccaccgc caccttacgt gtctgcctaa gccttcaagt gggcggagct gagggcagca   1140

gcttgacttt gcagacatct gagcaatagt tctgttattt cacttttgcc atgagcctct   1200

ctgagcttgt ttgttgctga aatgctactt tttaaaattt agatgttaga ttgaaaactg   1260

tagttttcaa catatgcttt gctggaacac tgtgatagat taactgtaga attcttcctg   1320

tacgattggg gatataatgg gcttcactaa ccttccctag gcattgaaac ttcccccaaa   1380

tctgatggac ctagaagtct gcttttgtac ctgctgggcc ccaaagttgg gcatttttct   1440

ctctgttccc tctcttttga aaatgtaaaa taaaaccaaa aatagacaac tttttcttca   1500

gccattccag catagagaac aaaaccttat ggaaacagga atgtcaattg tgtaatcatt   1560

gttctaatta ggtaaataga agtccttatg tatgtgttac aagaatttcc cccacaacat   1620

cctttatgac tgaagttcaa tgacagtttg tgtttggtgg taaaggattt tctccatggc   1680

ctgaattaag accattagaa agcaccaggc cgtgggagca gtgaccatct gctgactgtt   1740

cttgtggatc ttgtgtccag ggacatgggg tgacatgcct cgtatgtgtt agagggtgga   1800

atggatgtgt ttggcgctgc atgggatctg gtgcccctct tctcctggat tcacatcccc   1860

acccagggcc cgcttttact aagtgttctg ccctagattg gttcaaggag gtcatccaac   1920

tgactttatc aagtggaatt gggatatatt tgatatactt ctgcctaaca acatggaaaa   1980

gggttttctt ttccctgcaa gctacatcct actgctttga acttccaagt atgtctagtc   2040

accttttaaa atgtaaacat tttcagaaaa atgaggattg ccttccttgt atgcgctttt   2100

taccttgact acctgaattg caagggattt ttatatattc atatgttaca aagtcagcaa   2160

ctctcctgtt ggttcattat tgaatgtgct gtaaattaag ttgtttgcaa ttaaaacaag   2220

gtttgcccac atccaagaaa aa                                            2242


<210>  2330
<211>  317
<212>  PRT
<213>  Homosapiens

<400>  2330

Met Thr Ser Arg Thr Arg Val Thr Trp Pro Ser Pro Pro Arg Pro Leu 
1               5                   10                  15      


Pro Val Pro Ala Ala Ala Ala Val Ala Phe Gly Ala Lys Gly Thr Asp 
            20                  25                  30          


Pro Ala Glu Ala Arg Ser Ser Arg Gly Ile Glu Glu Ala Gly Pro Arg 
        35                  40                  45              


Ala His Gly Arg Ala Gly Arg Glu Pro Glu Arg Arg Arg Ser Arg Gln 
    50                  55                  60                  


Gln Arg Arg Gly Gly Leu Gln Ala Arg Arg Ser Thr Leu Leu Lys Thr 
65                  70                  75                  80  


Cys Ala Arg Ala Arg Ala Thr Ala Pro Gly Ala Met Lys Met Val Ala 
                85                  90                  95      


Pro Trp Thr Arg Phe Tyr Ser Asn Ser Cys Cys Leu Cys Cys His Val 
            100                 105                 110         


Arg Thr Gly Thr Ile Leu Leu Gly Val Trp Tyr Leu Ile Ile Asn Ala 
        115                 120                 125             


Val Val Leu Leu Ile Leu Leu Ser Ala Leu Ala Asp Pro Asp Gln Tyr 
    130                 135                 140                 


Asn Phe Ser Ser Ser Glu Leu Gly Gly Asp Phe Glu Phe Met Asp Asp 
145                 150                 155                 160 


Ala Asn Met Cys Ile Ala Ile Ala Ile Ser Leu Leu Met Ile Leu Ile 
                165                 170                 175     


Cys Ala Met Ala Thr Tyr Gly Ala Tyr Lys Gln Arg Ala Ala Trp Ile 
            180                 185                 190         


Ile Pro Phe Phe Cys Tyr Gln Ile Phe Asp Phe Ala Leu Asn Met Leu 
        195                 200                 205             


Val Ala Ile Thr Val Leu Ile Tyr Pro Asn Ser Ile Gln Glu Tyr Ile 
    210                 215                 220                 


Arg Gln Leu Pro Pro Asn Phe Pro Tyr Arg Asp Asp Val Met Ser Val 
225                 230                 235                 240 


Asn Pro Thr Cys Leu Val Leu Ile Ile Leu Leu Phe Ile Ser Ile Ile 
                245                 250                 255     


Leu Thr Phe Lys Gly Tyr Leu Ile Ser Cys Val Trp Asn Cys Tyr Arg 
            260                 265                 270         


Tyr Ile Asn Gly Arg Asn Ser Ser Asp Val Leu Val Tyr Val Thr Ser 
        275                 280                 285             


Asn Asp Thr Thr Val Leu Leu Pro Pro Tyr Asp Asp Ala Thr Val Asn 
    290                 295                 300                 


Gly Ala Ala Lys Glu Pro Pro Pro Pro Tyr Val Ser Ala 
305                 310                 315         


<210>  2331
<211>  2123
<212>  DNA
<213>  Homosapiens

<400>  2331
gcagcctgag gcagagctcg ggggctgtcg gtggggacct tgcaggaggg caccccaagc     60

ccgcccggcc cgcccaaccc agcccctgcg cgcagcccgg gccgagtagg accccgcgcg    120

cccctcgcta tggcggcgcc ctcgcggctc ctgatccgcg ggggtcgcgt ggtcaacgat    180

gacttctcgg aggtggccga cgtgctggtg gaggacggcg tggtgcgggc actcgggcac    240

gacctgctgc ctcccggggg cgctcctgcg gggctgcggg tcctcgacgc cgccggcaag    300

ctcgtcctgc ccggaggcat cgacacacac acgcacatgc agttcccctt catgggctcg    360

cggtccatcg acgacttcca ccagggcacc aaggctgctc tctcaggagg caccaccatg    420

attattgatt tcgccattcc tcagaaaggt ggctccctca ttgaggcctt cgagacctgg    480

cgaagctggg ctgatcccaa agtttgctgc gactacagcc ttcatgtggc agtgacgtgg    540

tggagtgacc aggttaaaga agaaatgaaa atccttgtgc aagataaagg tgttaactct    600

ttcaagatgt ttatggccta taaagatctg tacatggtga cagacctgga gctgtacgaa    660

gccttctctc ggtgcaagga aattggagca attgcccagg tccatgcgga aaatggagac    720

ttaattgcag agggagcaaa gaagatgttg gctctgggga taacaggccc tgagggccac    780

gagctgtgcc gcccagaggc agtggaggca gaggccacgc tgagagccat caccatagcc    840

agcgctgtga actgtcctct ctacattgtg catgtgatga gcaagtctgc agctaaggtg    900

atagcggatg caaggagaga tgggaaggtg gtctatggtg aacccatagc agccagtctt    960

ggcacagatg gcactcacta ctggaataaa gaatggcacc atgcagccca ccatgtcatg   1020

ggtccacctt tgcgaccaga cccctcaaca cccgacttcc tcatgaatct gttggctaat   1080

gatgatctaa ccacaacagg gactgataac tgcactttca acacctgcca gaaagctctt   1140

gggaaggatg attttaccaa gatccccaat ggggtgaatg gtgttgaaga tcggatgtcc   1200

gtaatatggg aaaaaggcgt gcatagtggt aaaatggatg aaaacagatt tgtggcagtt   1260

accagcacaa atgcagccaa aatttttaat ctctatccaa gaaaaggaag aatagctgta   1320

ggatcagatg ctgacattgt tatttgggac ccaaaaggca caaggactat ctcagcaaaa   1380

actcatcatc aggctgttaa cttcaacatt ttcgagggca tggtttgcca cggggtgccc   1440

cttgtgacta tttcaagagg caaagtggta tatgaagccg gagtgttcag tgtcacggca   1500

ggagatggga agtttattcc tcgaaaacca tttgctgaat atatttacaa acgaataaag   1560

cagcgagacc ggacttgcac acctacccct gtggagcgtg caccctataa gggagaagtc   1620

gccacactga aatccagagt gacaaaagaa gatgccacag cagggaccag gaaacaggcc   1680

cacccctgaa gtgtgtgcca tcggtaaaaa aaatcagagg aaaggaggct gccattccct   1740

tcacagccaa acattgtcaa cccatggaga agcaggcctt attcaactcc ctaggatcct   1800

ttagaaaaaa ttcaccacta taggcttctt tgattttctt tcagaagcaa ttgctgtctt   1860

tctcactgtg tttttgttgc tgcataagat tgaaggtata aatttatatt attgtgatgg   1920

aaaggctgtg tggaaattca ttgatgatac tttaaaatgt catctttgct tgtactagat   1980

ttcttactta gaatttttaa aaatcatttt cttgtttaaa tagtttcttt ttttaaaaaa   2040

atggttacat tagttttaaa atagctctgt gattttactt tttattgtaa ttaataaaca   2100

ttgagatctt cattttatac ctt                                           2123


<210>  2332
<211>  519
<212>  PRT
<213>  Homosapiens

<400>  2332

Met Ala Ala Pro Ser Arg Leu Leu Ile Arg Gly Gly Arg Val Val Asn 
1               5                   10                  15      


Asp Asp Phe Ser Glu Val Ala Asp Val Leu Val Glu Asp Gly Val Val 
            20                  25                  30          


Arg Ala Leu Gly His Asp Leu Leu Pro Pro Gly Gly Ala Pro Ala Gly 
        35                  40                  45              


Leu Arg Val Leu Asp Ala Ala Gly Lys Leu Val Leu Pro Gly Gly Ile 
    50                  55                  60                  


Asp Thr His Thr His Met Gln Phe Pro Phe Met Gly Ser Arg Ser Ile 
65                  70                  75                  80  


Asp Asp Phe His Gln Gly Thr Lys Ala Ala Leu Ser Gly Gly Thr Thr 
                85                  90                  95      


Met Ile Ile Asp Phe Ala Ile Pro Gln Lys Gly Gly Ser Leu Ile Glu 
            100                 105                 110         


Ala Phe Glu Thr Trp Arg Ser Trp Ala Asp Pro Lys Val Cys Cys Asp 
        115                 120                 125             


Tyr Ser Leu His Val Ala Val Thr Trp Trp Ser Asp Gln Val Lys Glu 
    130                 135                 140                 


Glu Met Lys Ile Leu Val Gln Asp Lys Gly Val Asn Ser Phe Lys Met 
145                 150                 155                 160 


Phe Met Ala Tyr Lys Asp Leu Tyr Met Val Thr Asp Leu Glu Leu Tyr 
                165                 170                 175     


Glu Ala Phe Ser Arg Cys Lys Glu Ile Gly Ala Ile Ala Gln Val His 
            180                 185                 190         


Ala Glu Asn Gly Asp Leu Ile Ala Glu Gly Ala Lys Lys Met Leu Ala 
        195                 200                 205             


Leu Gly Ile Thr Gly Pro Glu Gly His Glu Leu Cys Arg Pro Glu Ala 
    210                 215                 220                 


Val Glu Ala Glu Ala Thr Leu Arg Ala Ile Thr Ile Ala Ser Ala Val 
225                 230                 235                 240 


Asn Cys Pro Leu Tyr Ile Val His Val Met Ser Lys Ser Ala Ala Lys 
                245                 250                 255     


Val Ile Ala Asp Ala Arg Arg Asp Gly Lys Val Val Tyr Gly Glu Pro 
            260                 265                 270         


Ile Ala Ala Ser Leu Gly Thr Asp Gly Thr His Tyr Trp Asn Lys Glu 
        275                 280                 285             


Trp His His Ala Ala His His Val Met Gly Pro Pro Leu Arg Pro Asp 
    290                 295                 300                 


Pro Ser Thr Pro Asp Phe Leu Met Asn Leu Leu Ala Asn Asp Asp Leu 
305                 310                 315                 320 


Thr Thr Thr Gly Thr Asp Asn Cys Thr Phe Asn Thr Cys Gln Lys Ala 
                325                 330                 335     


Leu Gly Lys Asp Asp Phe Thr Lys Ile Pro Asn Gly Val Asn Gly Val 
            340                 345                 350         


Glu Asp Arg Met Ser Val Ile Trp Glu Lys Gly Val His Ser Gly Lys 
        355                 360                 365             


Met Asp Glu Asn Arg Phe Val Ala Val Thr Ser Thr Asn Ala Ala Lys 
    370                 375                 380                 


Ile Phe Asn Leu Tyr Pro Arg Lys Gly Arg Ile Ala Val Gly Ser Asp 
385                 390                 395                 400 


Ala Asp Ile Val Ile Trp Asp Pro Lys Gly Thr Arg Thr Ile Ser Ala 
                405                 410                 415     


Lys Thr His His Gln Ala Val Asn Phe Asn Ile Phe Glu Gly Met Val 
            420                 425                 430         


Cys His Gly Val Pro Leu Val Thr Ile Ser Arg Gly Lys Val Val Tyr 
        435                 440                 445             


Glu Ala Gly Val Phe Ser Val Thr Ala Gly Asp Gly Lys Phe Ile Pro 
    450                 455                 460                 


Arg Lys Pro Phe Ala Glu Tyr Ile Tyr Lys Arg Ile Lys Gln Arg Asp 
465                 470                 475                 480 


Arg Thr Cys Thr Pro Thr Pro Val Glu Arg Ala Pro Tyr Lys Gly Glu 
                485                 490                 495     


Val Ala Thr Leu Lys Ser Arg Val Thr Lys Glu Asp Ala Thr Ala Gly 
            500                 505                 510         


Thr Arg Lys Gln Ala His Pro 
        515                 


<210>  2333
<211>  4083
<212>  DNA
<213>  Homosapiens

<400>  2333
ctcctcctcc gtctcctcct ctctctctca tctgctgtgg ttatggcctg tcgctggagc     60

acaaaagagt ctccgcggtg gaggtctgcg ttgctcttgc ttttcctcgc tggggtgtac    120

ggaaatggtg ctcttgcaga acattctgaa aatgtgcata tttcaggagt gtcaactgct    180

tgtggagaga ctccagagca aatacgagca ccaagtggca taatcacaag cccaggctgg    240

ccttctgaat atcctgcaaa aatcaactgt agctggttca taagggcaaa cccaggcgaa    300

atcattacta taagttttca ggattttgat attcaaggat ccagaaggtg caatttggac    360

tggttgacaa tagaaacata caagaatatt gaaagttaca gagcttgtgg ttccacaatt    420

ccacctccgt atatctcttc acaagaccac atctggatta ggtttcattc ggatgacaac    480

atctctagaa agggtttcag actggcatat ttttcaggga aatctgagga accaaattgt    540

gcttgtgatc agtttcgttg tggtaatgga aagtgtatac cagaagcctg gaaatgtaat    600

aacatggatg aatgtggaga tagttccgat gaagagatct gtgccaaaga agcaaatcct    660

ccaactgctg ctgcttttca accctgtgct tacaaccagt tccagtgttt atcccgtttt    720

accaaagttt acacttgcct ccccgaatct ttaaaatgtg atgggaacat tgactgcctt    780

gacctaggag atgagataga ctgtgatgtg ccaacatgtg ggcaatggct aaaatatttt    840

tatggtactt ttaattctcc caattatcca gacttttatc ctcctggaag caattgcacc    900

tggttaatag acactggtga tcaccgtaaa gtcattttac gcttcactga ctttaaactt    960

gatggtactg gttatggtga ttatgtcaaa atatatgatg gattagagga gaatccacac   1020

aagcttttgc gtgtgttgac agcttttgat tctcatgcac ctcttacagt tgtttcttct   1080

tctggacaga taagggtaca tttttgtgct gataaagtga atgctgcaag gggatttaat   1140

gctacttacc aagtagatgg gttctgtttg ccatgggaaa taccctgtgg aggtaactgg   1200

gggtgttata ctgagcagca gcgttgtgat gggtattggc attgcccaaa tggaagggat   1260

gaaaccaatt gtaccatgtg ccagaaggaa gaatttccat gttcccgaaa tggtgtctgt   1320

tatcctcgtt ctgatcgctg caactaccag aatcattgcc caaatggctc agatgaaaaa   1380

aactgctttt tttgccaacc aggaaatttc cattgtaaaa acaatcgttg tgtgtttgaa   1440

agttgggtgt gtgattctca agatgactgt ggtgatggca gcgatgaaga aaattgccca   1500

gtaatcgtgc ctacaagagt catcactgct gccgtcatag ggagcctcat ctgtggcctg   1560

ttactcgtca tagcattggg atgtacttgt aagctttatt ctctgagaat gtttgaaaga   1620

agatcatttg aaacacagtt gtcaagagtg gaagcagaat tgttaagaag agaagctcct   1680

ccctcgtatg gacaattgat tgctcagggt ttaattccac cagttgaaga ttttcctgtt   1740

tgttcaccta atcaggcttc tgttttggaa aatctgaggc tagcggtacg atctcagctt   1800

ggatttactt cagtcaggct tcctatggca ggcagatcaa gcaacatttg gaaccgtatt   1860

tttaattttg caagatcacg tcattctggg tcattggctt tggtctcagc agatggagat   1920

gaggttgtcc ctagtcagag taccagtaga gaacctgaga gaaatcatac tcacagaagt   1980

ttgttttccg tggagtctga tgatacagac acagaaaatg agagaagaga tatggcagga   2040

gcatctggtg gggttgcagc tcctttgcct caaaaagtcc ctcccacaac ggcagtagaa   2100

gcgacagtag gagcatgtgc aagttcctca actcagagta cccgaggtgg tcatgcagat   2160

aatggaaggg atgtgacaag tgtggaaccc ccaagtgtga gtccagcacg tcaccagctt   2220

acaagtgcac tcagtcgtat gactcagggg ctacgctggg tacgttttac attaggacga   2280

tcaagttccc taagtcagaa ccagagtcct ttgagacaac ttgataatgg ggtaagtgga   2340

agagaagatg atgatgatgt tgaaatgcta attccaattt ctgatggatc ttcagacttt   2400

gatgtgaatg actgctccag acctcttctt gatcttgcct cagatcaagg acaagggctt   2460

agacaaccat ataatgcaac aaatcctgga gtaaggccaa gtaatcgaga tggcccctgt   2520

gagcgctgtg gtattgtcca cactgcccag ataccagaca cttgcttaga agtaacactg   2580

aaaaacgaaa cgagtgatga tgaggctttg ttactttgtt aggtacgaat cacataaggg   2640

agattgtata caagttggag caatatccat ttattatttt gtaactttac agttaaacta   2700

gttttagttt aaaaagaaaa aatgcagggt gatttcttat tattatatgt tagcctgcat   2760

ggttaaattc gacaacttgt aactctatga acttagagtt tactatttta gcagctaaaa   2820

atgcatcaca tattcatatt gttcaataat gtcctttcat ttgtttctga ttgttttcat   2880

cctgatactg tagttcactg tagaaatgtg gctgctgaaa ctcatttgat tgtcattttt   2940

atctatccta tgttaaatgg tttgttttta caaaataata ccttatttta attgaaacgt   3000

ttatgctttt gccaacacat cttgtaactt aatatactag atgttaaggt tgttaatgta   3060

caaaaaaaaa acccttatac tcacctgcgt tttcatttgt ttgacatttg tctattattg   3120

gatttcatta tcatatgaac ttgtcagtgg gaaacaaact gtctaaaaat ttttctctta   3180

cgtttaacat acaatcatgt gaaatttagg cagagttcga taaattactg gcaaaaacaa   3240

aactctttta taaagatttt ctaatgttga ctttaatact ctaacatggt acaaaccaaa   3300

tggtaaaatc ccaagtcatt tcttttttca tctctattta gcaacagaat taagtggatg   3360

aagatattct actatgcatt aaatcttgaa ctttataaaa catgtacaaa aattgtacaa   3420

gataagttcc acctggtaat gtctttccct aatacagggt tgcgcttgca ttggacccta   3480

gggatttgca ctaaaattat atcaaggtct cagatgagct tagtgcacaa gcactatcac   3540

tttaaatact attatttgct accacagcaa ctatatattt ccatagcttt tggctggggg   3600

cgggggacat ttttattaca acttgaaatt gctttgctgg tttcatattt atttgttgta   3660

tttaaaaaat acattgttgt aagagtgatt ttttcaatat attttattcc tgggggggat   3720

catgctacac tctcaaaaga aaattaagaa atcattcaga tcatcccccc tttttaagta   3780

gtgtgaattg caaaacccaa catatttttt ttactgtcag ttgcggttta tttattcttt   3840

aactgtctgt tttagtagtt taatgattat gaaaaatgta tctgtgtgtg atttgctatt   3900

tattaaattt taagtacttt gctgaatgtc attttaaagc atgtttgaag tcttgtgtat   3960

ttgtctgtgt taatgctgtc aggaggaact gactaagatg ttttaatatg tatcaaaaat   4020

taaaatgatt ttttttattg ccttgaggta ctttttaaaa aaaaaaaaaa aaaaaaaaaa   4080

aaa                                                                 4083


<210>  2334
<211>  859
<212>  PRT
<213>  Homosapiens

<400>  2334

Met Ala Cys Arg Trp Ser Thr Lys Glu Ser Pro Arg Trp Arg Ser Ala 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Ala Gly Val Tyr Gly Asn Gly Ala Leu Ala 
            20                  25                  30          


Glu His Ser Glu Asn Val His Ile Ser Gly Val Ser Thr Ala Cys Gly 
        35                  40                  45              


Glu Thr Pro Glu Gln Ile Arg Ala Pro Ser Gly Ile Ile Thr Ser Pro 
    50                  55                  60                  


Gly Trp Pro Ser Glu Tyr Pro Ala Lys Ile Asn Cys Ser Trp Phe Ile 
65                  70                  75                  80  


Arg Ala Asn Pro Gly Glu Ile Ile Thr Ile Ser Phe Gln Asp Phe Asp 
                85                  90                  95      


Ile Gln Gly Ser Arg Arg Cys Asn Leu Asp Trp Leu Thr Ile Glu Thr 
            100                 105                 110         


Tyr Lys Asn Ile Glu Ser Tyr Arg Ala Cys Gly Ser Thr Ile Pro Pro 
        115                 120                 125             


Pro Tyr Ile Ser Ser Gln Asp His Ile Trp Ile Arg Phe His Ser Asp 
    130                 135                 140                 


Asp Asn Ile Ser Arg Lys Gly Phe Arg Leu Ala Tyr Phe Ser Gly Lys 
145                 150                 155                 160 


Ser Glu Glu Pro Asn Cys Ala Cys Asp Gln Phe Arg Cys Gly Asn Gly 
                165                 170                 175     


Lys Cys Ile Pro Glu Ala Trp Lys Cys Asn Asn Met Asp Glu Cys Gly 
            180                 185                 190         


Asp Ser Ser Asp Glu Glu Ile Cys Ala Lys Glu Ala Asn Pro Pro Thr 
        195                 200                 205             


Ala Ala Ala Phe Gln Pro Cys Ala Tyr Asn Gln Phe Gln Cys Leu Ser 
    210                 215                 220                 


Arg Phe Thr Lys Val Tyr Thr Cys Leu Pro Glu Ser Leu Lys Cys Asp 
225                 230                 235                 240 


Gly Asn Ile Asp Cys Leu Asp Leu Gly Asp Glu Ile Asp Cys Asp Val 
                245                 250                 255     


Pro Thr Cys Gly Gln Trp Leu Lys Tyr Phe Tyr Gly Thr Phe Asn Ser 
            260                 265                 270         


Pro Asn Tyr Pro Asp Phe Tyr Pro Pro Gly Ser Asn Cys Thr Trp Leu 
        275                 280                 285             


Ile Asp Thr Gly Asp His Arg Lys Val Ile Leu Arg Phe Thr Asp Phe 
    290                 295                 300                 


Lys Leu Asp Gly Thr Gly Tyr Gly Asp Tyr Val Lys Ile Tyr Asp Gly 
305                 310                 315                 320 


Leu Glu Glu Asn Pro His Lys Leu Leu Arg Val Leu Thr Ala Phe Asp 
                325                 330                 335     


Ser His Ala Pro Leu Thr Val Val Ser Ser Ser Gly Gln Ile Arg Val 
            340                 345                 350         


His Phe Cys Ala Asp Lys Val Asn Ala Ala Arg Gly Phe Asn Ala Thr 
        355                 360                 365             


Tyr Gln Val Asp Gly Phe Cys Leu Pro Trp Glu Ile Pro Cys Gly Gly 
    370                 375                 380                 


Asn Trp Gly Cys Tyr Thr Glu Gln Gln Arg Cys Asp Gly Tyr Trp His 
385                 390                 395                 400 


Cys Pro Asn Gly Arg Asp Glu Thr Asn Cys Thr Met Cys Gln Lys Glu 
                405                 410                 415     


Glu Phe Pro Cys Ser Arg Asn Gly Val Cys Tyr Pro Arg Ser Asp Arg 
            420                 425                 430         


Cys Asn Tyr Gln Asn His Cys Pro Asn Gly Ser Asp Glu Lys Asn Cys 
        435                 440                 445             


Phe Phe Cys Gln Pro Gly Asn Phe His Cys Lys Asn Asn Arg Cys Val 
    450                 455                 460                 


Phe Glu Ser Trp Val Cys Asp Ser Gln Asp Asp Cys Gly Asp Gly Ser 
465                 470                 475                 480 


Asp Glu Glu Asn Cys Pro Val Ile Val Pro Thr Arg Val Ile Thr Ala 
                485                 490                 495     


Ala Val Ile Gly Ser Leu Ile Cys Gly Leu Leu Leu Val Ile Ala Leu 
            500                 505                 510         


Gly Cys Thr Cys Lys Leu Tyr Ser Leu Arg Met Phe Glu Arg Arg Ser 
        515                 520                 525             


Phe Glu Thr Gln Leu Ser Arg Val Glu Ala Glu Leu Leu Arg Arg Glu 
    530                 535                 540                 


Ala Pro Pro Ser Tyr Gly Gln Leu Ile Ala Gln Gly Leu Ile Pro Pro 
545                 550                 555                 560 


Val Glu Asp Phe Pro Val Cys Ser Pro Asn Gln Ala Ser Val Leu Glu 
                565                 570                 575     


Asn Leu Arg Leu Ala Val Arg Ser Gln Leu Gly Phe Thr Ser Val Arg 
            580                 585                 590         


Leu Pro Met Ala Gly Arg Ser Ser Asn Ile Trp Asn Arg Ile Phe Asn 
        595                 600                 605             


Phe Ala Arg Ser Arg His Ser Gly Ser Leu Ala Leu Val Ser Ala Asp 
    610                 615                 620                 


Gly Asp Glu Val Val Pro Ser Gln Ser Thr Ser Arg Glu Pro Glu Arg 
625                 630                 635                 640 


Asn His Thr His Arg Ser Leu Phe Ser Val Glu Ser Asp Asp Thr Asp 
                645                 650                 655     


Thr Glu Asn Glu Arg Arg Asp Met Ala Gly Ala Ser Gly Gly Val Ala 
            660                 665                 670         


Ala Pro Leu Pro Gln Lys Val Pro Pro Thr Thr Ala Val Glu Ala Thr 
        675                 680                 685             


Val Gly Ala Cys Ala Ser Ser Ser Thr Gln Ser Thr Arg Gly Gly His 
    690                 695                 700                 


Ala Asp Asn Gly Arg Asp Val Thr Ser Val Glu Pro Pro Ser Val Ser 
705                 710                 715                 720 


Pro Ala Arg His Gln Leu Thr Ser Ala Leu Ser Arg Met Thr Gln Gly 
                725                 730                 735     


Leu Arg Trp Val Arg Phe Thr Leu Gly Arg Ser Ser Ser Leu Ser Gln 
            740                 745                 750         


Asn Gln Ser Pro Leu Arg Gln Leu Asp Asn Gly Val Ser Gly Arg Glu 
        755                 760                 765             


Asp Asp Asp Asp Val Glu Met Leu Ile Pro Ile Ser Asp Gly Ser Ser 
    770                 775                 780                 


Asp Phe Asp Val Asn Asp Cys Ser Arg Pro Leu Leu Asp Leu Ala Ser 
785                 790                 795                 800 


Asp Gln Gly Gln Gly Leu Arg Gln Pro Tyr Asn Ala Thr Asn Pro Gly 
                805                 810                 815     


Val Arg Pro Ser Asn Arg Asp Gly Pro Cys Glu Arg Cys Gly Ile Val 
            820                 825                 830         


His Thr Ala Gln Ile Pro Asp Thr Cys Leu Glu Val Thr Leu Lys Asn 
        835                 840                 845             


Glu Thr Ser Asp Asp Glu Ala Leu Leu Leu Cys 
    850                 855                 


<210>  2335
<211>  1395
<212>  DNA
<213>  Homosapiens

<400>  2335
atgaaggagt acactaaaga tgaggaactg agtcaccgca atgccaaatg taacacgctg     60

tgggtcaaaa tttggatggt tgcgttggaa attattctga agccacagac agggctaaaa    120

ggactgagtt ctacatgtta tcagaacata ggtctgggaa ccagggaaga cgtcttgctg    180

aaaccgccaa taggaactag ctcctcaaaa cagagacgcc aatacagacg acaaaaccag    240

cagtcttcat ctgactctgg ttcctccttc tcctcagaag atgaacgacc caagagatcc    300

catgtgaaga atggtgaggt tggcaagcgg cggagacatt ccccttcccg gagtgcttct    360

ccatcaccac gaaagcacca aaaagagact tcccctcatg gtagacggag gagaagtcca    420

tccccaccac ccaccagaag gcgacggtct ccttctcccg cccctcatcc tcgacggctc    480

aggactccca caccaccacc accacgacga aggactcctt ctcctcccct acgtcggcgc    540

tcaccttctc ctagaagata ctctcctcca atacagagga gatactctcc ttctccacct    600

ccaaagagaa gaacggcttc acctcctccc cctcctaaac gaagagcatc accatttcca    660

ccaccaaagc ggcgggtctc ccattctcca ccttccaaag aagctcccca gtcaccaaga    720

gacgttcacc ttcactatca tccaagcata ggaaagggtc ttccccaagc cgctctaccc    780

gggaggcccg atcaccgcat ccaaacaaat ggcattcgcc ctcatcacgg cctcgagctc    840

ctcagacctc aagtcctcca cccgttcgaa gaggagcgtc gtcatcaccc caaagaaggc    900

agtccccgtc tccaagtact aggcccatta ggagagtctc caggactccg gaacctaaaa    960

agataaaaaa aggctgcttc cccaagccca cagtctgtaa ggagggtctc atcctcccga   1020

tctgtctctg ggtctcctga gccagcagct aaaaagcccc cagcatctcc atcccccatc   1080

cagtctcagt caccgtctac aaactggtca ccagctgtac cggtcaaaaa ggccaaaagc   1140

ccaacaccga gcccatcact gccaagaaat tcagatcaag aaggagatgg aaagaaaaag   1200

aagaaaaaga aggacaggaa acacaaaaag gataagaagc acaagaagca caaaaaacac   1260

aagaaggaaa aggctgtggc tgcagctgct gcagctgctg tgacccctgc agccattgca   1320

gctgccacaa ccacattagc acaggaagag ccagtggcag cgccagagcc gaagaaggag   1380

actgaaagaa aaaga                                                    1395


<210>  2336
<211>  321
<212>  PRT
<213>  Homosapiens

<400>  2336

Met Lys Glu Tyr Thr Lys Asp Glu Glu Leu Ser His Arg Asn Ala Lys 
1               5                   10                  15      


Cys Asn Thr Leu Trp Val Lys Ile Trp Met Val Ala Leu Glu Ile Ile 
            20                  25                  30          


Leu Lys Pro Gln Thr Gly Leu Lys Gly Leu Ser Ser Thr Cys Tyr Gln 
        35                  40                  45              


Asn Ile Gly Leu Gly Thr Arg Glu Asp Val Leu Leu Lys Pro Pro Ile 
    50                  55                  60                  


Gly Thr Ser Ser Ser Lys Gln Arg Arg Gln Tyr Arg Arg Gln Asn Gln 
65                  70                  75                  80  


Gln Ser Ser Ser Asp Ser Gly Ser Ser Phe Ser Ser Glu Asp Glu Arg 
                85                  90                  95      


Pro Lys Arg Ser His Val Lys Asn Gly Glu Val Gly Lys Arg Arg Arg 
            100                 105                 110         


His Ser Pro Ser Arg Ser Ala Ser Pro Ser Pro Arg Lys His Gln Lys 
        115                 120                 125             


Glu Thr Ser Pro His Gly Arg Arg Arg Arg Ser Pro Ser Pro Pro Pro 
    130                 135                 140                 


Thr Arg Arg Arg Arg Ser Pro Ser Pro Ala Pro His Pro Arg Arg Leu 
145                 150                 155                 160 


Arg Thr Pro Thr Pro Pro Pro Pro Arg Arg Arg Thr Pro Ser Pro Pro 
                165                 170                 175     


Leu Arg Arg Arg Ser Pro Ser Pro Arg Arg Tyr Ser Pro Pro Ile Gln 
            180                 185                 190         


Arg Arg Tyr Ser Pro Ser Pro Pro Pro Lys Arg Arg Thr Ala Ser Pro 
        195                 200                 205             


Pro Pro Pro Pro Lys Arg Arg Ala Ser Pro Phe Pro Pro Pro Lys Arg 
    210                 215                 220                 


Arg Val Ser His Ser Pro Pro Ser Lys Glu Ala Pro Gln Ser Pro Arg 
225                 230                 235                 240 


Asp Val His Leu His Tyr His Pro Ser Ile Gly Lys Gly Leu Pro Gln 
                245                 250                 255     


Ala Ala Leu Pro Gly Arg Pro Asp His Arg Ile Gln Thr Asn Gly Ile 
            260                 265                 270         


Arg Pro His His Gly Leu Glu Leu Leu Arg Pro Gln Val Leu His Pro 
        275                 280                 285             


Phe Glu Glu Glu Arg Arg His His Pro Lys Glu Gly Ser Pro Arg Leu 
    290                 295                 300                 


Gln Val Leu Gly Pro Leu Gly Glu Ser Pro Gly Leu Arg Asn Leu Lys 
305                 310                 315                 320 


Arg 
    


<210>  2337
<211>  3275
<212>  DNA
<213>  Homosapiens

<400>  2337
cgtgcgagtg tctccctctc cctctcgctc tctctctctc tccctctctc tctctctttt     60

gtgagttata gcaaccgttg ccttgtgaat caagcgccat agtcaccgta gtcctggcga    120

ctgttaccca tcaacaacaa ctactcctct cctcctcctc ctcctcttcc tcctcctcct    180

ccccaccacc accatctcca tcacccacca acaacaccac aataatccac agccaaggcc    240

acttggtcat tctggcattt tatggtagag aatacgttga gtttggctct ggaaggaata    300

tgagagacca tcatgcagac atcagagact gggtcggaca caggctcgac agtgacctta    360

caaacatctg tggctagtca agcagcagtg cctacgcagg tggtacagca agtaccagta    420

caacaacagg tacagcaggt acagactgtg cagcaggtac aacatgtcta tcccgctcag    480

gtgcagtatg tggaaggaag cgatactgtc tataccaatg gagcaatccg aacaacaacg    540

tatccttaca cagagacaca gatgtacagc caaaatactg gagggaatta ctttgatact    600

caagggagtt ccgcccaggt gactaccgtg gtctcatccc acagtatggt gggcactggt    660

gggattcaga tgggcgtcac aggaggacaa ctcatcagca gctctggagg aacctatctg    720

atcggcaact caatggagaa ttctggtcac tcagtgacac acacaactcg ggcctcccca    780

gcgacaattg aaatggcgat tgagacgctg caaaagtctg acggtctgtc cactcacaga    840

agctctcttc tcaacagcca tctccagtgg ctgttggaca attatgagac agcagaagga    900

gtgagccttc ccagaagcac tctgtacaac cactaccttc gacactgtca ggaacacaaa    960

ctggacccag tcaatgctgc ctcttttgga aaattaataa gatcaatttt tatggggcta   1020

cgaaccagga gattgggcac tagaggaaac tccaaatacc actactatgg gattcgtgtc   1080

aagccagatt cccctcttaa tcgtctgcaa gaagacatgc agtatatggc tatgagacaa   1140

caacccatgc aacagaaaca aaggtacaag cctatgcaga aagtggatgg ggttgcagat   1200

ggtttcacag gaagtggtca acagacaggc acatctgttg agcaaactgt aattgcccaa   1260

agccaacatc atcaacagtt tttagatgca tctcgagcac ttccagagtt tggagaagtt   1320

gaaatctctt ctctgccaga tggtactacc tttgaggata tcaagtcact gcagagtctt   1380

tatagagagc actgtgaggc aatattggac gttgttgtga atcttcaatt tagcctgata   1440

gaaaaattgt ggcaaacatt ctggcgctat tctccctcta ctccaactga tggcactacc   1500

attaccgaat cgagcaatct gagtgaaata gaaagtcgac ttccgaaagc aaagctgata   1560

actctgtgca aacatgagtc tatcctgaaa tggatgtgta actgtgacca tgggatgtac   1620

caggctttgg tggagattct catccccgac gtccttagac ctattcctag tgccttgacc   1680

caagccattc gaaattttgc aaaaagcctt gaaggttggc tttccaatgc catgaacaat   1740

attccacaga gaatgataca aaccaaggtt gccgctgtaa gtgcctttgc ccagactctg   1800

cgaagataca cgtcgcttaa tcacctggcc caggcagctc gtgcagtgct tcagaacact   1860

tcccaaatca accagatgct tagtgacctc aaccgtgtcg actttgccaa tgtccaggag   1920

caggcttcct gggtgtgcca gtgtgatgac aacatggttc agagactaga aacagacttc   1980

aagatgactc ttcagcagca gagcaccctg gagcagtggg ctgcgtggct tgacaatgtg   2040

atgatgcaag cactgaaacc ctatgaagga agacccagtt ttcctaaagc cgccaggcag   2100

tttctgctaa aatggtcttt ctacagctca atggttattc gggacttaac cttacgcagt   2160

gctgctagct ttggctcctt ccacctgatc cgtctactct acgacgaata tatgttttac   2220

ttagtagaac atcgtgttgc tcaggcaaca ggagagactc ctatagcagt catgggcgag   2280

gtaagagagg ctgaaagagc tgtgacccac tgggttatta aaaataagcc agaattacac   2340

ttcagtctaa atacattatt gattaaaacc atggttccta accaagtcag cctcagagcc   2400

aggagggact gtggagttat tgcaagagtt ccttaaattc ctctgttctt atgtgcttaa   2460

tcaaaagatt ctaaaattgt ggattatatc atgtgaaagt tcatggaatg tgtctctata   2520

ttatacaggt acctatgtaa aagaaaaact tgagaaccac tggaatatga aaaatatttt   2580

aagtgggaaa aagattggtg ctcctgataa agcaaagggc tgggaataca atggaaagga   2640

ttaaatatgt attttgtaga ctctttcccg gtctccaaga acaaagtaaa tgattctatt   2700

ttagaaggat aaaaatggta atgatgataa ctaacatttt ttggacactt actatgtgcg   2760

aggcacagtt ctatgttttt tacatgtaat aaagcactta atgcaagtct ttgagatacg   2820

ttctacttta ttctgtttta caataagcat ccgaggttta tgcagaaagc taaggcacag   2880

aaaggttaaa tgattactca gctaaaaaat ggtagagatt tttttttcaa acacagtctg   2940

attttcaaac ccatatgctt ctaaccacta atgatgtaag ggggaaaatt ctcttcttca   3000

gaatttctga atagtcatca aaatggctta tcaaaaagct taaactctga atataacaag   3060

ggctggttaa tataatgagg aatagatgca aatgctcaga tggttcagca ctggcttatt   3120

ttgttatatt gaatgcagga ggcgggggta gtttatacct tgtcgaatca taccagatta   3180

ttaaatgtga caaattaccc aaggcggtaa aaaagacatg ttcactttta agctatgtgt   3240

atgtgcttat ataaataaaa aagagtgaaa acaga                              3275


<210>  2338
<211>  707
<212>  PRT
<213>  Homosapiens

<400>  2338

Met Gln Thr Ser Glu Thr Gly Ser Asp Thr Gly Ser Thr Val Thr Leu 
1               5                   10                  15      


Gln Thr Ser Val Ala Ser Gln Ala Ala Val Pro Thr Gln Val Val Gln 
            20                  25                  30          


Gln Val Pro Val Gln Gln Gln Val Gln Gln Val Gln Thr Val Gln Gln 
        35                  40                  45              


Val Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu Gly Ser Asp 
    50                  55                  60                  


Thr Val Tyr Thr Asn Gly Ala Ile Arg Thr Thr Thr Tyr Pro Tyr Thr 
65                  70                  75                  80  


Glu Thr Gln Met Tyr Ser Gln Asn Thr Gly Gly Asn Tyr Phe Asp Thr 
                85                  90                  95      


Gln Gly Ser Ser Ala Gln Val Thr Thr Val Val Ser Ser His Ser Met 
            100                 105                 110         


Val Gly Thr Gly Gly Ile Gln Met Gly Val Thr Gly Gly Gln Leu Ile 
        115                 120                 125             


Ser Ser Ser Gly Gly Thr Tyr Leu Ile Gly Asn Ser Met Glu Asn Ser 
    130                 135                 140                 


Gly His Ser Val Thr His Thr Thr Arg Ala Ser Pro Ala Thr Ile Glu 
145                 150                 155                 160 


Met Ala Ile Glu Thr Leu Gln Lys Ser Asp Gly Leu Ser Thr His Arg 
                165                 170                 175     


Ser Ser Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu 
            180                 185                 190         


Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Thr Leu Tyr Asn His Tyr 
        195                 200                 205             


Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser 
    210                 215                 220                 


Phe Gly Lys Leu Ile Arg Ser Ile Phe Met Gly Leu Arg Thr Arg Arg 
225                 230                 235                 240 


Leu Gly Thr Arg Gly Asn Ser Lys Tyr His Tyr Tyr Gly Ile Arg Val 
                245                 250                 255     


Lys Pro Asp Ser Pro Leu Asn Arg Leu Gln Glu Asp Met Gln Tyr Met 
            260                 265                 270         


Ala Met Arg Gln Gln Pro Met Gln Gln Lys Gln Arg Tyr Lys Pro Met 
        275                 280                 285             


Gln Lys Val Asp Gly Val Ala Asp Gly Phe Thr Gly Ser Gly Gln Gln 
    290                 295                 300                 


Thr Gly Thr Ser Val Glu Gln Thr Val Ile Ala Gln Ser Gln His His 
305                 310                 315                 320 


Gln Gln Phe Leu Asp Ala Ser Arg Ala Leu Pro Glu Phe Gly Glu Val 
                325                 330                 335     


Glu Ile Ser Ser Leu Pro Asp Gly Thr Thr Phe Glu Asp Ile Lys Ser 
            340                 345                 350         


Leu Gln Ser Leu Tyr Arg Glu His Cys Glu Ala Ile Leu Asp Val Val 
        355                 360                 365             


Val Asn Leu Gln Phe Ser Leu Ile Glu Lys Leu Trp Gln Thr Phe Trp 
    370                 375                 380                 


Arg Tyr Ser Pro Ser Thr Pro Thr Asp Gly Thr Thr Ile Thr Glu Ser 
385                 390                 395                 400 


Ser Asn Leu Ser Glu Ile Glu Ser Arg Leu Pro Lys Ala Lys Leu Ile 
                405                 410                 415     


Thr Leu Cys Lys His Glu Ser Ile Leu Lys Trp Met Cys Asn Cys Asp 
            420                 425                 430         


His Gly Met Tyr Gln Ala Leu Val Glu Ile Leu Ile Pro Asp Val Leu 
        435                 440                 445             


Arg Pro Ile Pro Ser Ala Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys 
    450                 455                 460                 


Ser Leu Glu Gly Trp Leu Ser Asn Ala Met Asn Asn Ile Pro Gln Arg 
465                 470                 475                 480 


Met Ile Gln Thr Lys Val Ala Ala Val Ser Ala Phe Ala Gln Thr Leu 
                485                 490                 495     


Arg Arg Tyr Thr Ser Leu Asn His Leu Ala Gln Ala Ala Arg Ala Val 
            500                 505                 510         


Leu Gln Asn Thr Ser Gln Ile Asn Gln Met Leu Ser Asp Leu Asn Arg 
        515                 520                 525             


Val Asp Phe Ala Asn Val Gln Glu Gln Ala Ser Trp Val Cys Gln Cys 
    530                 535                 540                 


Asp Asp Asn Met Val Gln Arg Leu Glu Thr Asp Phe Lys Met Thr Leu 
545                 550                 555                 560 


Gln Gln Gln Ser Thr Leu Glu Gln Trp Ala Ala Trp Leu Asp Asn Val 
                565                 570                 575     


Met Met Gln Ala Leu Lys Pro Tyr Glu Gly Arg Pro Ser Phe Pro Lys 
            580                 585                 590         


Ala Ala Arg Gln Phe Leu Leu Lys Trp Ser Phe Tyr Ser Ser Met Val 
        595                 600                 605             


Ile Arg Asp Leu Thr Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His 
    610                 615                 620                 


Leu Ile Arg Leu Leu Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His 
625                 630                 635                 640 


Arg Val Ala Gln Ala Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu 
                645                 650                 655     


Val Arg Glu Ala Glu Arg Ala Val Thr His Trp Val Ile Lys Asn Lys 
            660                 665                 670         


Pro Glu Leu His Phe Ser Leu Asn Thr Leu Leu Ile Lys Thr Met Val 
        675                 680                 685             


Pro Asn Gln Val Ser Leu Arg Ala Arg Arg Asp Cys Gly Val Ile Ala 
    690                 695                 700                 


Arg Val Pro 
705         


<210>  2339
<211>  3018
<212>  DNA
<213>  Homosapiens

<400>  2339
cgtgcgagtg tctccctctc cctctcgctc tctctctctc tccctctctc tctctctttt     60

gtgagttata gcaaccgttg ccttgtgaat caagcgccat agtcaccgta gtcctggcga    120

ctgttaccca tcaacaacaa ctactcctct cctcctcctc ctcctcttcc tcctcctcct    180

ccccaccacc accatctcca tcacccacca acaacaccac aataatccac agccaaggcc    240

acttggtcat tctggcattt tatggtagag aatacgttga gtttggctct ggaaggaata    300

tgagagacca tcatgcagac atcagagact gggtcggaca caggctcgac agtgacctta    360

caaacatctg tggctagtca agcagcagtg cctacgcagg tggtacagca agtaccagta    420

caacaacagg tacagcaggt acagactgtg cagcaggtac aacatgtcta tcccgctcag    480

gtgcagtatg tggaaggaag cgatactgtc tataccaatg gagcaatccg aacaacaacg    540

tatccttaca cagagacaca gatgtacagc caaaatactg gagggaatta ctttgatact    600

caagggagtt ccgcccaggt gactaccgtg gtctcatccc acagtatggt gggcactggt    660

gggattcaga tgggcgtcac aggaggacaa ctcatcagca gctctggagg aacctatctg    720

atcggcaact caatggagaa ttctggtcac tcagtgacac acacaactcg ggcctcccca    780

gcgacaattg aaatggcgat tgagacgctg caaaagtctg acggtctgtc cactcacaga    840

agctctcttc tcaacagcca tctccagtgg ctgttggaca attatgagac agcagaagga    900

gtgagccttc ccagaagcac tctgtacaac cactaccttc gacactgtca ggaacacaaa    960

ctggacccag tcaatgctgc ctcttttgga aaattaataa gatcaatttt tatggggcta   1020

cgaaccagga gattgggcac tagaggaaac tccaaatacc actactatgg gattcgtgtc   1080

aagccagatt cccctcttaa tcgtctgcaa gaagacatgc agtatatggc tatgagacaa   1140

caacccatgc aacagaaaca aaggtacaag cctatgcaga aagtggatgg ggttgcagat   1200

ggtttcacag gaagtggtca acagacaggc acatctgttg agcaaactgt aattgcccaa   1260

agccaacatc atcaacagtt tttagatgca tctcgagcac ttccagagtt tggagaagtt   1320

gaaatctctt ctctgccaga tggtactacc tttgaggata tcaagtcact gcagagtctt   1380

tatagagagc actgtgaggc aatattggac gttgttgtga atcttcaatt tagcctgata   1440

gaaaaattgt ggcaaacatt ctggcgctat tctccctcta ctccaactga tggcactacc   1500

attaccgaat cgagcaatct gagtgaaata gaaagtcgac ttccgaaagc aaagctgata   1560

actctgtgca aacatgagtc tatcctgaaa tggatgtgta actgtgacca tgggatgtac   1620

caggctttgg tggagattct catccccgac gtccttagac ctattcctag tgccttgacc   1680

caagccattc gaaattttgc aaaaagcctt gaaggttggc tttccaatgc catgaacaat   1740

attccacaga gaatgataca aaccaaggtt gccgctgtaa gtgcctttgc ccagactctg   1800

cgaagataca cgtcgcttaa tcacctggcc caggcagctc gtgcagtgct tcagaacact   1860

tcccaaatca accagatgct tagtgacctc aaccgtgtcg actttgccaa tgtccaggag   1920

caggcttcct gggtgtgcca gtgtgatgac aacatggttc agagactaga aacagacttc   1980

aagatgactc ttcagcagca gagcaccctg gagcagtggg ctgcgtggct tgacaatgtg   2040

atgatgcaag cactgaaacc ctatgaagga agacccagtt ttcctaaagc cgccaggcag   2100

tttctgctaa aatggtcttt ctacagctca atggttattc gggacttaac cttacgcagt   2160

gctgctagct ttggctcctt ccacctgatc cgtctactct acgacgaata tatgttttac   2220

ttagtagaac atcgtgttgc tcaggcaaca ggagagactc ctatagcagt catgggcgag   2280

tttggtgatt taaatgccgt gtctcctgga aatctggata aagatgaagg cagtgaagta   2340

gaaagtgaaa tggatgaaga actggatgac tcttcagagc ctcaagccaa aagagagaaa   2400

acagagctga gccaggcatt tccagtgggc tgcatgcagc ctgttctcga gactggcgtg   2460

caaccaagcc tcctgaatcc aattcacagc gagcacattg tcacaagtac tcagactatc   2520

agacagtgca gcgctacagg aaatacctac actgcagtct aaagaatatt aaagcgtatt   2580

tttccagctt acattaaccc tgttgatatt gggcttaagt tgaaaattta ataagcctga   2640

aggtcgactg ttgtcaaatt ctatctgtgc tgaacattaa ctttttggag ttgtgaaatg   2700

gaatgggtgt atgtattttg ccagatcttt ttttttaacg taaacaaatt atttgcttct   2760

taataatgaa ttttttccct tagtttcagg tgtcaagaag gatttttaca acacttaatg   2820

tcaatgtttt gttttcttat aattaaaaag taatttacat tttttgtagc ttaaaatatt   2880

ttattgttga ttgttagtct tggtgtatga tttcatgtgt aagtttttta attagatgca   2940

cttctgtgaa atatcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3000

aaaaaaaaaa aaaaaaaa                                                 3018


<210>  2340
<211>  749
<212>  PRT
<213>  Homosapiens

<400>  2340

Met Gln Thr Ser Glu Thr Gly Ser Asp Thr Gly Ser Thr Val Thr Leu 
1               5                   10                  15      


Gln Thr Ser Val Ala Ser Gln Ala Ala Val Pro Thr Gln Val Val Gln 
            20                  25                  30          


Gln Val Pro Val Gln Gln Gln Val Gln Gln Val Gln Thr Val Gln Gln 
        35                  40                  45              


Val Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu Gly Ser Asp 
    50                  55                  60                  


Thr Val Tyr Thr Asn Gly Ala Ile Arg Thr Thr Thr Tyr Pro Tyr Thr 
65                  70                  75                  80  


Glu Thr Gln Met Tyr Ser Gln Asn Thr Gly Gly Asn Tyr Phe Asp Thr 
                85                  90                  95      


Gln Gly Ser Ser Ala Gln Val Thr Thr Val Val Ser Ser His Ser Met 
            100                 105                 110         


Val Gly Thr Gly Gly Ile Gln Met Gly Val Thr Gly Gly Gln Leu Ile 
        115                 120                 125             


Ser Ser Ser Gly Gly Thr Tyr Leu Ile Gly Asn Ser Met Glu Asn Ser 
    130                 135                 140                 


Gly His Ser Val Thr His Thr Thr Arg Ala Ser Pro Ala Thr Ile Glu 
145                 150                 155                 160 


Met Ala Ile Glu Thr Leu Gln Lys Ser Asp Gly Leu Ser Thr His Arg 
                165                 170                 175     


Ser Ser Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu 
            180                 185                 190         


Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Thr Leu Tyr Asn His Tyr 
        195                 200                 205             


Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser 
    210                 215                 220                 


Phe Gly Lys Leu Ile Arg Ser Ile Phe Met Gly Leu Arg Thr Arg Arg 
225                 230                 235                 240 


Leu Gly Thr Arg Gly Asn Ser Lys Tyr His Tyr Tyr Gly Ile Arg Val 
                245                 250                 255     


Lys Pro Asp Ser Pro Leu Asn Arg Leu Gln Glu Asp Met Gln Tyr Met 
            260                 265                 270         


Ala Met Arg Gln Gln Pro Met Gln Gln Lys Gln Arg Tyr Lys Pro Met 
        275                 280                 285             


Gln Lys Val Asp Gly Val Ala Asp Gly Phe Thr Gly Ser Gly Gln Gln 
    290                 295                 300                 


Thr Gly Thr Ser Val Glu Gln Thr Val Ile Ala Gln Ser Gln His His 
305                 310                 315                 320 


Gln Gln Phe Leu Asp Ala Ser Arg Ala Leu Pro Glu Phe Gly Glu Val 
                325                 330                 335     


Glu Ile Ser Ser Leu Pro Asp Gly Thr Thr Phe Glu Asp Ile Lys Ser 
            340                 345                 350         


Leu Gln Ser Leu Tyr Arg Glu His Cys Glu Ala Ile Leu Asp Val Val 
        355                 360                 365             


Val Asn Leu Gln Phe Ser Leu Ile Glu Lys Leu Trp Gln Thr Phe Trp 
    370                 375                 380                 


Arg Tyr Ser Pro Ser Thr Pro Thr Asp Gly Thr Thr Ile Thr Glu Ser 
385                 390                 395                 400 


Ser Asn Leu Ser Glu Ile Glu Ser Arg Leu Pro Lys Ala Lys Leu Ile 
                405                 410                 415     


Thr Leu Cys Lys His Glu Ser Ile Leu Lys Trp Met Cys Asn Cys Asp 
            420                 425                 430         


His Gly Met Tyr Gln Ala Leu Val Glu Ile Leu Ile Pro Asp Val Leu 
        435                 440                 445             


Arg Pro Ile Pro Ser Ala Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys 
    450                 455                 460                 


Ser Leu Glu Gly Trp Leu Ser Asn Ala Met Asn Asn Ile Pro Gln Arg 
465                 470                 475                 480 


Met Ile Gln Thr Lys Val Ala Ala Val Ser Ala Phe Ala Gln Thr Leu 
                485                 490                 495     


Arg Arg Tyr Thr Ser Leu Asn His Leu Ala Gln Ala Ala Arg Ala Val 
            500                 505                 510         


Leu Gln Asn Thr Ser Gln Ile Asn Gln Met Leu Ser Asp Leu Asn Arg 
        515                 520                 525             


Val Asp Phe Ala Asn Val Gln Glu Gln Ala Ser Trp Val Cys Gln Cys 
    530                 535                 540                 


Asp Asp Asn Met Val Gln Arg Leu Glu Thr Asp Phe Lys Met Thr Leu 
545                 550                 555                 560 


Gln Gln Gln Ser Thr Leu Glu Gln Trp Ala Ala Trp Leu Asp Asn Val 
                565                 570                 575     


Met Met Gln Ala Leu Lys Pro Tyr Glu Gly Arg Pro Ser Phe Pro Lys 
            580                 585                 590         


Ala Ala Arg Gln Phe Leu Leu Lys Trp Ser Phe Tyr Ser Ser Met Val 
        595                 600                 605             


Ile Arg Asp Leu Thr Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His 
    610                 615                 620                 


Leu Ile Arg Leu Leu Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His 
625                 630                 635                 640 


Arg Val Ala Gln Ala Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu 
                645                 650                 655     


Phe Gly Asp Leu Asn Ala Val Ser Pro Gly Asn Leu Asp Lys Asp Glu 
            660                 665                 670         


Gly Ser Glu Val Glu Ser Glu Met Asp Glu Glu Leu Asp Asp Ser Ser 
        675                 680                 685             


Glu Pro Gln Ala Lys Arg Glu Lys Thr Glu Leu Ser Gln Ala Phe Pro 
    690                 695                 700                 


Val Gly Cys Met Gln Pro Val Leu Glu Thr Gly Val Gln Pro Ser Leu 
705                 710                 715                 720 


Leu Asn Pro Ile His Ser Glu His Ile Val Thr Ser Thr Gln Thr Ile 
                725                 730                 735     


Arg Gln Cys Ser Ala Thr Gly Asn Thr Tyr Thr Ala Val 
            740                 745                 


<210>  2341
<211>  4359
<212>  DNA
<213>  Homosapiens

<400>  2341
gttgtaaact tcacctcccg ggggctcttc cccttctgta cccctttgct gtttgtcccc     60

ctcctcccgg gtcctggagt ccgtcgtgtt ccaacagttt ttgctcttat tcccgtgggc    120

tgcctgggcc tcctttcacc cgtgagactt ggagcggccc ctggggtctt gggtgtgcag    180

cacggatcac gcgagacccc tgagacctca aatcatctaa cgtgaagcca cagacatctt    240

gggcaatttt aatcatcaag aaagaaatat gtcattaaga aatagcaggg tattttgaaa    300

gagttggaaa acatcatgaa tttgaatact tcaagtaata ctggtgatac ccaaaggttg    360

aagattgcct cattggatgt aaaacaaata cttaaaaatg aaacagagtt ggatattact    420

gataatctca ggaagaaact ccattgggct aaaaaagaaa agttagaaat aacaaccaaa    480

cacaatgcag agctggcaag ctatgagagc cagattgcca agctacggtc cgaggttgaa    540

aagggagaag cattgcgaca aagtctggaa tatgacctag ctgttgctag aaaggaagct    600

ggtcttggaa gacgggctgc tgaagaaaga ttagccgagg cacataggat ccaagaaaaa    660

ctctgtgcac agaattcaga acttcaagca aagacaaatg agactgagaa agcatttcag    720

acttctcagc aaaaatggaa agaagaatgc agaagatttg aacatgattt ggaggaaaga    780

gacaatatga tccaaaattg caatcgagaa tatgatttac ttatgaaaga aaaaagcaga    840

ctagagaaaa ctctacagga agcgttggaa aaacatcaac gggagaagaa tgagatggag    900

tctcatatca gggagacagc attggaggag tttagattac aagaagaaca atgggaagca    960

gaaagaagag aattacaatt tatagtacag gagcaagata ctgctgtgca aaatatgcat   1020

aagaaagtag aaaaattaga aacagaacat atggactgct ctgacctttt acggcgacaa   1080

acaagtgaac ttgaatttag cactcaacga gaggaacgcc ttagaaaaga atttgaggca   1140

actactctaa gagtgaggaa attagaagaa aacattgaag cagaaagagc agcgcatttg   1200

gaatcaaaat ttaattctga aattattcag ttacggattc gagaccttga aggagctttg   1260

caagtagaga aggccagtca agcagaagct gttgctgatt tggaaattat caagaatgaa   1320

ttcaaagaag ttgaaagtgc atatgagcga gaaaagcata atgcacaaga gagctttgca   1380

aaactaaatt tattagaaaa agagtatttc tccaaaaata agaaactaaa tgaagacatc   1440

gaggaacaga agaaagtaat tatagacctt tcaaagagac tccagtataa tgaaaaaagt   1500

tgcagtgaat tacaggaaga actagtaatg gctaagaagc accaggcctt cctagtagag   1560

acatgtgaaa ataacgtgaa agaattggaa tcgatcttgg acagctttac tgtgtcgggc   1620

cagtggacat caggcatcca caaggacaaa gataaacctc ccagcttctc tgttgtcctt   1680

gagagattga ggcgtacctt gacagattac cagaacaagc tggaagatgc atctaatgag   1740

gaaaaggcat gtaatgaact tgattctacg aaacagaaga tagactctca cactaaaaat   1800

ataaaggaac ttcaggataa actggctgat gttaataaag agttaagtca tttacacact   1860

aaatgtgcag accgagaggc tttaataagc actttaaaag tggaactaca aaatgtgctg   1920

cactgttggg agaaagaaaa ggctcaggca gcccagtctg aaagtgaact gcagaagctt   1980

tcccaggctt tccataagga tgcagaggag aagctaacct tccttcacac cttatatcag   2040

cacttggtag caggctgtgt gctcataaaa caaccagaag gcatgctgga taaattctct   2100

tggtctgagc tttgtgcagt cttacaggag aatgttgatg ccctgattgc agacctcaac   2160

agggctaatg agaagataag gcatctagag tatatctgta aaaacaagtc tgacacgatg   2220

agagagcttc agcagactca ggaagacacc tttaccaaag tggcagaaca gatcaaagcc   2280

caagagagct gctggcacag acaaaagaag gaactagagc tgcagtattc tgaactcttc   2340

ctggaggtgc agaagagggc acagaaattt caagaaattg ctgaaaaaaa catggaaaaa   2400

ttgaaccata ttgagaagtc acatgaacag ttggttcttg aaaattcgca cttcaaaaaa   2460

ctgttatcac agactcaaag ggaacagatg tccttgctgg cagcctgtgc attaatggct   2520

ggtgccttat atcccctcta tagccgatca tgcgccttgt ctacacagag agattttctc   2580

caggagcagg tcaacacctt tgagttgttc aaactggaaa ttagaactct agcccaggct   2640

ttgtcaactg tagaggaaaa gaagcaagag gaagccaaga tgaaaaagaa aacattcaaa   2700

ggattgatac gtatatttcg gaaaggtgtt attgctgttt tggcagcaaa cagactcaag   2760

attttgggcc aatcatgtgc ctctcttttt acctggatgg agagtttcaa agaaggcata   2820

ggcatgttag tgtgcacagg agagccccaa gacaagcata aatttccaaa acatcaaaag   2880

gagcagttgc gttgtttaca agcgctcagt tggctcacca gttctgacct tcttgctgca   2940

ataatcagtt ctatggctga attacaagac gtcattggta aagcagatcc aaattccaga   3000

atttgtggac atttactcat aggtgcagcc aagaattctt ttgcaaaact catggataaa   3060

attagtctgg taatggaatg tatacctctg cacagtagca ggagtattac atatgtagaa   3120

aaagattccc tggttcagag gctggcccat ggacttcata aagtaaacac actggccctg   3180

aaatatggtt tgcgtggcca tgtgcccatt acgaaaagca cagcatcgtt gcagaagcaa   3240

atacttggat ttacacaaag actgcatgct gcagaagtgg agcgccgctc actacgctta   3300

gaggtcacag aattcaaacg aagtgtgaat gaaatgaaaa aggagcttga caaagcccag   3360

ggtctgcaaa tgcaattaaa tgaatttaag cagtctaaat tgatcaccca tgagaagttt   3420

gaaagtgcat gtgaagaact aaataatgca ttacttcggg aagagcaggc acaaatgcta   3480

ttgaatgaac aggcacaaca actacaggaa ttgaattata aacttgaatt gcactccagt   3540

gaggaagctg acaaaaacca aactcttgga gaagctgtta agagtctctc cgaggcaaag   3600

atggagctga gaagaaaaga tcaatctctg cgtcagctca atagacatct tacccagctg   3660

gagcaggaca agcgtcgact ggaggagaac atccatgatg cagagagtgc cctccgcatg   3720

gcagccaaag acaaagaatg tgttgctaat cacatgagag cagtagaaaa tacgcttcac   3780

aaggtcagag atcagatctc gctgtcatgg tctgcggcaa gtaggaatga cttcacccta   3840

cagctaccca aactgcacct ggagaccttt gcaatggagg ggctcaaggg cgggccagag   3900

gtggtagcat gccaggctat gattaaaagt ttcatggatg tctaccagct tgcaagcact   3960

agaatcatga cattagagaa ggaaatgaca tctcatcgaa gtcacattgc agccttgaaa   4020

tcagaacttc acacagcttg tttacgtgaa aatgcaagtt tacaatcaat aggatcacga   4080

gaccattcaa atctctccat tccttcaaga gctcctcttc ctgctgacac aactggtatt   4140

ggggatttct taccattgaa agctgaactt gatactactt acactttctt aaaggagaca   4200

tttataaata ctgtgcccca tgctctgaca tcatctcact cctctccagt gactatgtct   4260

gctaatgcca acagaccaac tcagattgga ttatgacttc atgaaattaa aaaatggagg   4320

aagagttaac agtacaatta aaattgtttt gaatgggaa                          4359


<210>  2342
<211>  1326
<212>  PRT
<213>  Homosapiens

<400>  2342

Met Asn Leu Asn Thr Ser Ser Asn Thr Gly Asp Thr Gln Arg Leu Lys 
1               5                   10                  15      


Ile Ala Ser Leu Asp Val Lys Gln Ile Leu Lys Asn Glu Thr Glu Leu 
            20                  25                  30          


Asp Ile Thr Asp Asn Leu Arg Lys Lys Leu His Trp Ala Lys Lys Glu 
        35                  40                  45              


Lys Leu Glu Ile Thr Thr Lys His Asn Ala Glu Leu Ala Ser Tyr Glu 
    50                  55                  60                  


Ser Gln Ile Ala Lys Leu Arg Ser Glu Val Glu Lys Gly Glu Ala Leu 
65                  70                  75                  80  


Arg Gln Ser Leu Glu Tyr Asp Leu Ala Val Ala Arg Lys Glu Ala Gly 
                85                  90                  95      


Leu Gly Arg Arg Ala Ala Glu Glu Arg Leu Ala Glu Ala His Arg Ile 
            100                 105                 110         


Gln Glu Lys Leu Cys Ala Gln Asn Ser Glu Leu Gln Ala Lys Thr Asn 
        115                 120                 125             


Glu Thr Glu Lys Ala Phe Gln Thr Ser Gln Gln Lys Trp Lys Glu Glu 
    130                 135                 140                 


Cys Arg Arg Phe Glu His Asp Leu Glu Glu Arg Asp Asn Met Ile Gln 
145                 150                 155                 160 


Asn Cys Asn Arg Glu Tyr Asp Leu Leu Met Lys Glu Lys Ser Arg Leu 
                165                 170                 175     


Glu Lys Thr Leu Gln Glu Ala Leu Glu Lys His Gln Arg Glu Lys Asn 
            180                 185                 190         


Glu Met Glu Ser His Ile Arg Glu Thr Ala Leu Glu Glu Phe Arg Leu 
        195                 200                 205             


Gln Glu Glu Gln Trp Glu Ala Glu Arg Arg Glu Leu Gln Phe Ile Val 
    210                 215                 220                 


Gln Glu Gln Asp Thr Ala Val Gln Asn Met His Lys Lys Val Glu Lys 
225                 230                 235                 240 


Leu Glu Thr Glu His Met Asp Cys Ser Asp Leu Leu Arg Arg Gln Thr 
                245                 250                 255     


Ser Glu Leu Glu Phe Ser Thr Gln Arg Glu Glu Arg Leu Arg Lys Glu 
            260                 265                 270         


Phe Glu Ala Thr Thr Leu Arg Val Arg Lys Leu Glu Glu Asn Ile Glu 
        275                 280                 285             


Ala Glu Arg Ala Ala His Leu Glu Ser Lys Phe Asn Ser Glu Ile Ile 
    290                 295                 300                 


Gln Leu Arg Ile Arg Asp Leu Glu Gly Ala Leu Gln Val Glu Lys Ala 
305                 310                 315                 320 


Ser Gln Ala Glu Ala Val Ala Asp Leu Glu Ile Ile Lys Asn Glu Phe 
                325                 330                 335     


Lys Glu Val Glu Ser Ala Tyr Glu Arg Glu Lys His Asn Ala Gln Glu 
            340                 345                 350         


Ser Phe Ala Lys Leu Asn Leu Leu Glu Lys Glu Tyr Phe Ser Lys Asn 
        355                 360                 365             


Lys Lys Leu Asn Glu Asp Ile Glu Glu Gln Lys Lys Val Ile Ile Asp 
    370                 375                 380                 


Leu Ser Lys Arg Leu Gln Tyr Asn Glu Lys Ser Cys Ser Glu Leu Gln 
385                 390                 395                 400 


Glu Glu Leu Val Met Ala Lys Lys His Gln Ala Phe Leu Val Glu Thr 
                405                 410                 415     


Cys Glu Asn Asn Val Lys Glu Leu Glu Ser Ile Leu Asp Ser Phe Thr 
            420                 425                 430         


Val Ser Gly Gln Trp Thr Ser Gly Ile His Lys Asp Lys Asp Lys Pro 
        435                 440                 445             


Pro Ser Phe Ser Val Val Leu Glu Arg Leu Arg Arg Thr Leu Thr Asp 
    450                 455                 460                 


Tyr Gln Asn Lys Leu Glu Asp Ala Ser Asn Glu Glu Lys Ala Cys Asn 
465                 470                 475                 480 


Glu Leu Asp Ser Thr Lys Gln Lys Ile Asp Ser His Thr Lys Asn Ile 
                485                 490                 495     


Lys Glu Leu Gln Asp Lys Leu Ala Asp Val Asn Lys Glu Leu Ser His 
            500                 505                 510         


Leu His Thr Lys Cys Ala Asp Arg Glu Ala Leu Ile Ser Thr Leu Lys 
        515                 520                 525             


Val Glu Leu Gln Asn Val Leu His Cys Trp Glu Lys Glu Lys Ala Gln 
    530                 535                 540                 


Ala Ala Gln Ser Glu Ser Glu Leu Gln Lys Leu Ser Gln Ala Phe His 
545                 550                 555                 560 


Lys Asp Ala Glu Glu Lys Leu Thr Phe Leu His Thr Leu Tyr Gln His 
                565                 570                 575     


Leu Val Ala Gly Cys Val Leu Ile Lys Gln Pro Glu Gly Met Leu Asp 
            580                 585                 590         


Lys Phe Ser Trp Ser Glu Leu Cys Ala Val Leu Gln Glu Asn Val Asp 
        595                 600                 605             


Ala Leu Ile Ala Asp Leu Asn Arg Ala Asn Glu Lys Ile Arg His Leu 
    610                 615                 620                 


Glu Tyr Ile Cys Lys Asn Lys Ser Asp Thr Met Arg Glu Leu Gln Gln 
625                 630                 635                 640 


Thr Gln Glu Asp Thr Phe Thr Lys Val Ala Glu Gln Ile Lys Ala Gln 
                645                 650                 655     


Glu Ser Cys Trp His Arg Gln Lys Lys Glu Leu Glu Leu Gln Tyr Ser 
            660                 665                 670         


Glu Leu Phe Leu Glu Val Gln Lys Arg Ala Gln Lys Phe Gln Glu Ile 
        675                 680                 685             


Ala Glu Lys Asn Met Glu Lys Leu Asn His Ile Glu Lys Ser His Glu 
    690                 695                 700                 


Gln Leu Val Leu Glu Asn Ser His Phe Lys Lys Leu Leu Ser Gln Thr 
705                 710                 715                 720 


Gln Arg Glu Gln Met Ser Leu Leu Ala Ala Cys Ala Leu Met Ala Gly 
                725                 730                 735     


Ala Leu Tyr Pro Leu Tyr Ser Arg Ser Cys Ala Leu Ser Thr Gln Arg 
            740                 745                 750         


Asp Phe Leu Gln Glu Gln Val Asn Thr Phe Glu Leu Phe Lys Leu Glu 
        755                 760                 765             


Ile Arg Thr Leu Ala Gln Ala Leu Ser Thr Val Glu Glu Lys Lys Gln 
    770                 775                 780                 


Glu Glu Ala Lys Met Lys Lys Lys Thr Phe Lys Gly Leu Ile Arg Ile 
785                 790                 795                 800 


Phe Arg Lys Gly Val Ile Ala Val Leu Ala Ala Asn Arg Leu Lys Ile 
                805                 810                 815     


Leu Gly Gln Ser Cys Ala Ser Leu Phe Thr Trp Met Glu Ser Phe Lys 
            820                 825                 830         


Glu Gly Ile Gly Met Leu Val Cys Thr Gly Glu Pro Gln Asp Lys His 
        835                 840                 845             


Lys Phe Pro Lys His Gln Lys Glu Gln Leu Arg Cys Leu Gln Ala Leu 
    850                 855                 860                 


Ser Trp Leu Thr Ser Ser Asp Leu Leu Ala Ala Ile Ile Ser Ser Met 
865                 870                 875                 880 


Ala Glu Leu Gln Asp Val Ile Gly Lys Ala Asp Pro Asn Ser Arg Ile 
                885                 890                 895     


Cys Gly His Leu Leu Ile Gly Ala Ala Lys Asn Ser Phe Ala Lys Leu 
            900                 905                 910         


Met Asp Lys Ile Ser Leu Val Met Glu Cys Ile Pro Leu His Ser Ser 
        915                 920                 925             


Arg Ser Ile Thr Tyr Val Glu Lys Asp Ser Leu Val Gln Arg Leu Ala 
    930                 935                 940                 


His Gly Leu His Lys Val Asn Thr Leu Ala Leu Lys Tyr Gly Leu Arg 
945                 950                 955                 960 


Gly His Val Pro Ile Thr Lys Ser Thr Ala Ser Leu Gln Lys Gln Ile 
                965                 970                 975     


Leu Gly Phe Thr Gln Arg Leu His Ala Ala Glu Val Glu Arg Arg Ser 
            980                 985                 990         


Leu Arg Leu Glu Val Thr Glu Phe  Lys Arg Ser Val Asn  Glu Met Lys 
        995                 1000                 1005             


Lys Glu  Leu Asp Lys Ala Gln  Gly Leu Gln Met Gln  Leu Asn Glu 
    1010                 1015                 1020             


Phe Lys  Gln Ser Lys Leu Ile  Thr His Glu Lys Phe  Glu Ser Ala 
    1025                 1030                 1035             


Cys Glu  Glu Leu Asn Asn Ala  Leu Leu Arg Glu Glu  Gln Ala Gln 
    1040                 1045                 1050             


Met Leu  Leu Asn Glu Gln Ala  Gln Gln Leu Gln Glu  Leu Asn Tyr 
    1055                 1060                 1065             


Lys Leu  Glu Leu His Ser Ser  Glu Glu Ala Asp Lys  Asn Gln Thr 
    1070                 1075                 1080             


Leu Gly  Glu Ala Val Lys Ser  Leu Ser Glu Ala Lys  Met Glu Leu 
    1085                 1090                 1095             


Arg Arg  Lys Asp Gln Ser Leu  Arg Gln Leu Asn Arg  His Leu Thr 
    1100                 1105                 1110             


Gln Leu  Glu Gln Asp Lys Arg  Arg Leu Glu Glu Asn  Ile His Asp 
    1115                 1120                 1125             


Ala Glu  Ser Ala Leu Arg Met  Ala Ala Lys Asp Lys  Glu Cys Val 
    1130                 1135                 1140             


Ala Asn  His Met Arg Ala Val  Glu Asn Thr Leu His  Lys Val Arg 
    1145                 1150                 1155             


Asp Gln  Ile Ser Leu Ser Trp  Ser Ala Ala Ser Arg  Asn Asp Phe 
    1160                 1165                 1170             


Thr Leu  Gln Leu Pro Lys Leu  His Leu Glu Thr Phe  Ala Met Glu 
    1175                 1180                 1185             


Gly Leu  Lys Gly Gly Pro Glu  Val Val Ala Cys Gln  Ala Met Ile 
    1190                 1195                 1200             


Lys Ser  Phe Met Asp Val Tyr  Gln Leu Ala Ser Thr  Arg Ile Met 
    1205                 1210                 1215             


Thr Leu  Glu Lys Glu Met Thr  Ser His Arg Ser His  Ile Ala Ala 
    1220                 1225                 1230             


Leu Lys  Ser Glu Leu His Thr  Ala Cys Leu Arg Glu  Asn Ala Ser 
    1235                 1240                 1245             


Leu Gln  Ser Ile Gly Ser Arg  Asp His Ser Asn Leu  Ser Ile Pro 
    1250                 1255                 1260             


Ser Arg  Ala Pro Leu Pro Ala  Asp Thr Thr Gly Ile  Gly Asp Phe 
    1265                 1270                 1275             


Leu Pro  Leu Lys Ala Glu Leu  Asp Thr Thr Tyr Thr  Phe Leu Lys 
    1280                 1285                 1290             


Glu Thr  Phe Ile Asn Thr Val  Pro His Ala Leu Thr  Ser Ser His 
    1295                 1300                 1305             


Ser Ser  Pro Val Thr Met Ser  Ala Asn Ala Asn Arg  Pro Thr Gln 
    1310                 1315                 1320             


Ile Gly  Leu 
    1325     


<210>  2343
<211>  2792
<212>  DNA
<213>  Homosapiens

<400>  2343
aatttagaga agatgtaggg agtgttcaac atgttcgttg tggaagagaa agagctaaga     60

gagaggagct taaagacaca aacgggtaga atcaaggagt gtgctctcaa atgagaggaa    120

caggagtgac attaaccttg aaatgctcgg agactctact ccttcatgac agtaggagga    180

taattaacaa tagatacaaa tgcaggaatt gatgagtgcc atcagaaagc tgtatcatga    240

gctgcctgca cttctaaagt gtccagtgga tttttaatca catgagcctg gaaatagggt    300

tatgaaaaga agctcagagc agagcaccga aagtggccac taccagcatg aagagcccaa    360

caattcaaac tggtgaagtg agaaaaacag aatgcagctt tcaaggttcg tttcaagcag    420

ttggcttgtg ggactctgag agatgctgct gcccatgaca tgcgggaatt atcatgatca    480

actacccagc ttggatttca tccagtggcc aagagctttg tgtgggagac ggcaagggtt    540

ggatttttca aaagagtaaa ccaggataaa tcatgaggaa cctataaccc ttttggccac    600

atgcaaaaaa gcaagacccg tgaccaaggt gtagactaag aagtggagtc atgcttcaca    660

cggccatatc atgctggcag ccattcctgg gtctggctgt ggtgttaatc ttcatgggat    720

ccaccattgg ctgccccgct cgctgtgagt gctctgccca gaacaaatct gttagctgtc    780

acagaaggcg attgatcgcc atcccagagg gcattcccat cgaaaccaaa atcttggacc    840

tcagtaaaaa caggctaaaa agcgtcaacc ctgaagaatt catatcatat cctctgctgg    900

aagagataga cttgagtgac aacatcattg ccaatgtgga accaggagca ttcaacaatc    960

tctttaacct gcgttccctc cgcctaaaag gcaatcgtct aaagctggtc cctttgggag   1020

tattcacggg gctgtccaat ctcactaagc ttgacattag tgagaataag attgtcattt   1080

tactagacta catgttccaa gatctacata acctgaagtc tctagaagtg ggggacaatg   1140

atttggttta tatatcacac agggcattca gtgggcttct tagcttggag cagctcaccc   1200

tggagaaatg caacttaaca gcagtaccaa cagaagccct ctcccacctc cgcagcctca   1260

tcagcctgca tctgaagcat ctcaatatca acaatatgcc tgtgtatgcc tttaaaagat   1320

tgttccacct gaaacaccta gagattgact attggccttt actggatatg atgcctgcca   1380

atagcctcta cggtctcaac ctcacatccc tttcagtcac caacaccaat ctgtctactg   1440

tacccttcct tgcctttaaa cacctggtat acctgactca ccttaacctc tcctacaatc   1500

ccatcagcac tattgaagca ggcatgttct ctgacctgat ccgccttcag gagcttcata   1560

tagtgggggc ccagcttcgc accattgagc ctcactcctt ccaagggctc cgcttcctac   1620

gcgtgctcaa tgtgtctcag aacctgctgg aaactttgga agagaatgtc ttctcctccc   1680

ctagggctct ggaggtcttg agcattaaca acaaccctct ggcctgtgac tgccgccttc   1740

tctggatctt gcagcgacag cccaccctgc agtttggtgg ccagcaacct atgtgtgctg   1800

gcccagacac catccgtgag aggtctttca aggatttcca tagcactgcc ctttcttttt   1860

actttacctg caaaaaaccc aaaatccgtg aaaagaagtt gcagcatctg ctagtagatg   1920

aagggcagac agtccagcta gaatgcagtg cagatggaga cccgcagcct gtgatttcct   1980

gggtgacacc ccgaaggcgt ttcatcacca ccaagtccaa tggaagagcc accgtgttgg   2040

gtgatggcac cttggaaatc cgctttgccc aggatcaaga cagcgggatg tatgtttgca   2100

tcgctagcaa tgctgctggg aatgatacct tcacagcctc cttaactgtg aaaggattcg   2160

cttcagatcg ttttctttat gcgaacagga cccctatgta catgaccgac tccaatgaca   2220

ccatttccaa tggcaccaat gccaatactt tttccctgga ccttaaaaca atactggtgt   2280

ctacagctat gggctgcttc acattcctgg gagtggtttt attttgtttt cttctccttt   2340

ttgtgtggag ccgagggaaa ggcaagcaca aaaacagcat tgaccttgag tatgtgccca   2400

gaaaaaacaa tggtgctgtt gtggaaggag aggtagctgg acccaggagg ttcaacatga   2460

aaatgatttg aaggcccacc cctcacatta ctgtctcttt gtcaatgtgg gtaatcagta   2520

agacagtatg gcacagtaaa ttactagatt aagaggcagc catgtgcagc tgcccctgta   2580

tcaaaagcag ggtctatgga agcaggagga cttccaatgg agactctcca tcgaaaggca   2640

ggcaggcagg catgtgtcag agcccttcac acagtgggat actaagtgtt tgcgttgcaa   2700

atattggcgt tctggggatc tcagtaatga acctgaatat ttggctcaca ctcacggaca   2760

attattcagc attttctacc actgcaaaaa ac                                 2792


<210>  2344
<211>  606
<212>  PRT
<213>  Homosapiens

<400>  2344

Met Leu His Thr Ala Ile Ser Cys Trp Gln Pro Phe Leu Gly Leu Ala 
1               5                   10                  15      


Val Val Leu Ile Phe Met Gly Ser Thr Ile Gly Cys Pro Ala Arg Cys 
            20                  25                  30          


Glu Cys Ser Ala Gln Asn Lys Ser Val Ser Cys His Arg Arg Arg Leu 
        35                  40                  45              


Ile Ala Ile Pro Glu Gly Ile Pro Ile Glu Thr Lys Ile Leu Asp Leu 
    50                  55                  60                  


Ser Lys Asn Arg Leu Lys Ser Val Asn Pro Glu Glu Phe Ile Ser Tyr 
65                  70                  75                  80  


Pro Leu Leu Glu Glu Ile Asp Leu Ser Asp Asn Ile Ile Ala Asn Val 
                85                  90                  95      


Glu Pro Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Ser Leu Arg Leu 
            100                 105                 110         


Lys Gly Asn Arg Leu Lys Leu Val Pro Leu Gly Val Phe Thr Gly Leu 
        115                 120                 125             


Ser Asn Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu 
    130                 135                 140                 


Leu Asp Tyr Met Phe Gln Asp Leu His Asn Leu Lys Ser Leu Glu Val 
145                 150                 155                 160 


Gly Asp Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu 
                165                 170                 175     


Leu Ser Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ala Val 
            180                 185                 190         


Pro Thr Glu Ala Leu Ser His Leu Arg Ser Leu Ile Ser Leu His Leu 
        195                 200                 205             


Lys His Leu Asn Ile Asn Asn Met Pro Val Tyr Ala Phe Lys Arg Leu 
    210                 215                 220                 


Phe His Leu Lys His Leu Glu Ile Asp Tyr Trp Pro Leu Leu Asp Met 
225                 230                 235                 240 


Met Pro Ala Asn Ser Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Val 
                245                 250                 255     


Thr Asn Thr Asn Leu Ser Thr Val Pro Phe Leu Ala Phe Lys His Leu 
            260                 265                 270         


Val Tyr Leu Thr His Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile 
        275                 280                 285             


Glu Ala Gly Met Phe Ser Asp Leu Ile Arg Leu Gln Glu Leu His Ile 
    290                 295                 300                 


Val Gly Ala Gln Leu Arg Thr Ile Glu Pro His Ser Phe Gln Gly Leu 
305                 310                 315                 320 


Arg Phe Leu Arg Val Leu Asn Val Ser Gln Asn Leu Leu Glu Thr Leu 
                325                 330                 335     


Glu Glu Asn Val Phe Ser Ser Pro Arg Ala Leu Glu Val Leu Ser Ile 
            340                 345                 350         


Asn Asn Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Ile Leu Gln 
        355                 360                 365             


Arg Gln Pro Thr Leu Gln Phe Gly Gly Gln Gln Pro Met Cys Ala Gly 
    370                 375                 380                 


Pro Asp Thr Ile Arg Glu Arg Ser Phe Lys Asp Phe His Ser Thr Ala 
385                 390                 395                 400 


Leu Ser Phe Tyr Phe Thr Cys Lys Lys Pro Lys Ile Arg Glu Lys Lys 
                405                 410                 415     


Leu Gln His Leu Leu Val Asp Glu Gly Gln Thr Val Gln Leu Glu Cys 
            420                 425                 430         


Ser Ala Asp Gly Asp Pro Gln Pro Val Ile Ser Trp Val Thr Pro Arg 
        435                 440                 445             


Arg Arg Phe Ile Thr Thr Lys Ser Asn Gly Arg Ala Thr Val Leu Gly 
    450                 455                 460                 


Asp Gly Thr Leu Glu Ile Arg Phe Ala Gln Asp Gln Asp Ser Gly Met 
465                 470                 475                 480 


Tyr Val Cys Ile Ala Ser Asn Ala Ala Gly Asn Asp Thr Phe Thr Ala 
                485                 490                 495     


Ser Leu Thr Val Lys Gly Phe Ala Ser Asp Arg Phe Leu Tyr Ala Asn 
            500                 505                 510         


Arg Thr Pro Met Tyr Met Thr Asp Ser Asn Asp Thr Ile Ser Asn Gly 
        515                 520                 525             


Thr Asn Ala Asn Thr Phe Ser Leu Asp Leu Lys Thr Ile Leu Val Ser 
    530                 535                 540                 


Thr Ala Met Gly Cys Phe Thr Phe Leu Gly Val Val Leu Phe Cys Phe 
545                 550                 555                 560 


Leu Leu Leu Phe Val Trp Ser Arg Gly Lys Gly Lys His Lys Asn Ser 
                565                 570                 575     


Ile Asp Leu Glu Tyr Val Pro Arg Lys Asn Asn Gly Ala Val Val Glu 
            580                 585                 590         


Gly Glu Val Ala Gly Pro Arg Arg Phe Asn Met Lys Met Ile 
        595                 600                 605     


<210>  2345
<211>  5101
<212>  DNA
<213>  Homosapiens

<400>  2345
cggaacccgg tcgaaagggt cctctctggc gtccttctgc ttccgtgggt ttctggatag     60

gctgcgtttt gttctcaggg gatgcaagtt cttcctttca gggttgaagc gtgagagagg    120

ttggtttttg aaacgggagt gtttcaggtt attgaggtcc aaaaagaaat aaagtttttg    180

tttacgtctg tatggcttgt aagatatctc ccggggccaa ttcagcatct ctacctggcc    240

atcctaacaa ggtgatttgt gaaagggtga gacttcagag cctgttccct ctcctcccaa    300

gtgatcagaa cactaccgtt caagaggatg ctcacttcaa agctttcttc cagagtgaag    360

atagtccaag tcctaagaga cagcgcctct ctcattcagt ctttgattat acatcagcat    420

caccagctcc ctcaccacca atgcgaccat gggagatgac atcaaatagg cagccccctt    480

cagttcgacc aagccaacat cacttctcag gggaacgatg caacacacct gcacgcaaca    540

gaagaagtcc tcctgtcagg cgccagagag gaagaaggga tcgtctgtct cgacataatt    600

ccattagtca agatgaaaac tatcaccatc tcccttacgc acagcagcaa gcaatagagg    660

agcctcgagc cttccaccct ccgaatgtat ctccccgtct gctacatcct gctgctcatc    720

caccccagca gaatgcagtc atggttgaca tacatgatca gctccatcaa ggaacagtcc    780

ctgtttctta cacagtaaca acagtggcac cacatgggat tccactctgc acaggccagc    840

acatccctgc ttgtagtaca cagcaggtcc caggatgctc tgtggttttc agtggacagc    900

acctccctgt ctgtagtgtg cctcctccaa tgcttcaggc atgttcagtt cagcacttac    960

cagtaccata tgctgcattc ccacccctta tttctagtga tccatttctt atacatcctc   1020

ctcacctttc tccccatcat cctcctcatt tgccaccacc aggccagttt gtccctttcc   1080

aaacacagca atcacgatcg cctctgcaaa ggatagaaaa tgaagtggaa ctcttaggag   1140

aacatcttcc agtaggaggt tttacttacc ctccatcagc ccacccccca acattacctc   1200

catcagctcc cttgcagttc ttaacacatg atcctttgca tcaggaggtg tcctttggag   1260

taccttatcc tccatttatg cctcggaggc ttacaggacg tagtagatac cgatcccagc   1320

agccaatacc acctccccct tatcatccca gcttactgcc atatgtgtta tcaatgcttc   1380

cagtgccacc tgcagtgggc ccaactttca gctttgaatt agatgtagaa gatggagaag   1440

tagaaaatta cgaggccctg ttaaacctgg cagagcgact gggagaggca aagcctcgtg   1500

gactgactaa agcagatatt gaacaacttc cttcttatcg gttcaatcct aacaaccacc   1560

agtcagaaca gactttgtgt gtagtatgca tgtgtgattt tgagtcaagg cagctactta   1620

gagtcttacc ctgtaaccac gagttccatg ccaagtgtgt tgacaaatgg cttaaggcaa   1680

atcgtacttg cccaatttgc cgagctgatg cttcagaagt gcatcgggat tcagaatgac   1740

caacctaaga agcacaaatt tagtttgggt gttcctcatc acatgtatat acggactatc   1800

cattgaactt aatctgtgtg gcttccagcc ctccctttac caaaagggtc aatggacctt   1860

tctttgcact gtgtgactta atcaactata aaagcttaca attagtcttc acagttatgg   1920

gattgttata ctaaccgtgt gattggaact ccaaagactt tttctttagc ttaattttgt   1980

gtgtgcacta acattccctg gtttttgtgt gatcattccg agtgttgctg caagattaca   2040

gtggacgtga tcttttagca tgtgctttta taaaaagtgg tagctacaga tgatatagca   2100

atctacctta tatagagcct tcagaaactg tgagtggaaa tgaatgcgca gcgtatgact   2160

gttggtgata agtgtatctg tgtgagtgtg tgcaactact tgtgtgaggg catggtagct   2220

aacgtgtgta tgagatccta tataccagca tgtaccaaga atgtgtgtgt agttttaatt   2280

atgctgcaat gtataatctg gtgtgttatt taaacagcac tagtactgta cactggtttt   2340

tttcccttgt gtttgctgtt gcacactgat tgctgagggt gcatcaatta caagcattga   2400

atactccatc cccttccctc ccagtgaatg gaatgagaaa agccttcttc ctttgcttca   2460

ggcagctgtc accttctctt tattggtggt cctaagtggg tcacttaaga aaaaaaagtg   2520

taacaaattc tcgctccatg aacctggttt ttttttattc tgttgtggaa atttttaaat   2580

ctccaacttg ctgtttccaa aaagaaggtg caatatcata tatcatcagt tagcaatatt   2640

agcatttcaa tcagtgattt gaatgttgat actttttttt cctttacatt tccagtaagt   2700

ttcttacaga aagtacctgt gatttttttt aatgtttaga tttgtagtct agtctattct   2760

gaagatattt gattaatata tttctaagaa gaccactagt cccatgaagt ctcaccttgt   2820

tgacttccac cagaacaaaa cctgttaatt cagcttgact tctcatatgt gttctgtgtt   2880

caagctcctg tgggcaactc aattgtttta agaaaactct atttctgttc atattaattc   2940

acttgccaga ctccaattct gaaagttgtc tagttcttcc ttcatcacac gtgcttctca   3000

tcgaaaccct ggtttcagga tggatcaagt gctgttacag ctcatgttcc ttagacctga   3060

tttgttttga tattttactg cctttccttt taatttttgt ttgaatgaga aaagtttaat   3120

acaacaggtg tccagaatac ttgcagtata aatgaagatt tggtttttgt ataaaaaaat   3180

aatgctgtta aacaggagtt gaccttcatt tagttgatgt aatacatagc tgtatggggt   3240

tttttttagt aagttctttg agcataattc actttaaagt catttttcca gcaatgttta   3300

aattactttc tcattctttt agtgtattca acattgtctg cctcttcctg cagttgatgt   3360

aattgctttg tttgcaatag cacaagctgc attattccag tcaggactgt gataacttgc   3420

tgccagcccc actcaacttt cagttggctc tgtgtcagtt ttccattcag tgttaactac   3480

ttgttactgc catgctgctt gccctccctt gaagtgtcta taagctcatc acagcctaga   3540

gttaagtaaa gtcaattcac agaagcacaa ttttgccctt tgcgagacat tgttgcctct   3600

atctagtcct acaagtaggg ttttgcatac tgtgtttgcc cctagggttg tcagtgcatc   3660

agaaatactt ctaaatagtg gtaaaaatgc acatggttaa tgcacatgtt acttttaaat   3720

cattaggata tccctcacct gttcctgatg aataaaaagt gtgttaaaga ccaaaattct   3780

tggcataata atcagctaca tacaaatcac atatagttta atctttttta atgaaaaaaa   3840

atcatgttta aaatggcaaa agcccatctt atacactttt atatagctgc aaaaaattta   3900

tatctgtaca gatctaacac tacgacactc agtattcatt ttattgaagc atgcaagtaa   3960

agcacttttt ctaatttata tagaggtatc taattaacac agcacattgt actaatgact   4020

aggagtagca gctttttctt ctctccctct atgaattctt ataatgtccc tttttctgta   4080

agtttttgag aggcaattgg caatttagga ggcagcaggg tctgttttgg tcaaatcttg   4140

aatttcgttg ttgcactcta gtgactgatc tttgggaatg tcttgtcttt gcatggggct   4200

catagagatg tgtgcagact tgcttattgt ggttagtgtg tatcaggaac acacacacag   4260

gtgttctgac cagctcaggc ttgccacagt gagcaactct gtggctagca aaagagaagt   4320

ttatttgtgc ccagccattg gtcaccttgg gtgatgcacc agatagcagg cagatgttgg   4380

ttcattggcc ttcgtcctct ttcctcctaa aataatattg gctttaccat cttaactcag   4440

ctgtgggttt tttgtgggtt cttgtttgtt ttttggcatg aattgtcatc tttggtgttt   4500

ttttaacccc cagcccctca aaaaaataag gcctccaggt atcaagatct catattagga   4560

ttttctgtcc ttaatttttt gagcaaaatc tggaaaatgt gaaagcatat ttagatttta   4620

tatactatct gaaatgtgat ttgttaagat tcttaaattt gggcctctta gaataatttt   4680

gaatgagatc taccgactca cttgtgagaa tatttttcac agattatctt tgggcctttt   4740

cattagaaag ctgtttgttt gtccccctgt tggtacattt ggttacctca ttttgccgtt   4800

tcagattgtg aaagctcaca ggggtgtttt ttggaatcat ttgctgagtc attttctcaa   4860

atcatattcc attgtatcag ttaacatata gttttaaatg tatgtattat aaatatctgt   4920

aaccaaatca tttgaaggct tgataaattt ttaacaaagt ttgtacattt tttatgaaag   4980

ttactagtaa tgctttacta agtagtgcaa tgaattttta tttttaatcc ctgtgcccaa   5040

ttttggagtt gagagggttg ttggtaataa atgtatgatg tacacttaaa aaaaaaaaaa   5100

a                                                                   5101


<210>  2346
<211>  515
<212>  PRT
<213>  Homosapiens

<400>  2346

Met Ala Cys Lys Ile Ser Pro Gly Ala Asn Ser Ala Ser Leu Pro Gly 
1               5                   10                  15      


His Pro Asn Lys Val Ile Cys Glu Arg Val Arg Leu Gln Ser Leu Phe 
            20                  25                  30          


Pro Leu Leu Pro Ser Asp Gln Asn Thr Thr Val Gln Glu Asp Ala His 
        35                  40                  45              


Phe Lys Ala Phe Phe Gln Ser Glu Asp Ser Pro Ser Pro Lys Arg Gln 
    50                  55                  60                  


Arg Leu Ser His Ser Val Phe Asp Tyr Thr Ser Ala Ser Pro Ala Pro 
65                  70                  75                  80  


Ser Pro Pro Met Arg Pro Trp Glu Met Thr Ser Asn Arg Gln Pro Pro 
                85                  90                  95      


Ser Val Arg Pro Ser Gln His His Phe Ser Gly Glu Arg Cys Asn Thr 
            100                 105                 110         


Pro Ala Arg Asn Arg Arg Ser Pro Pro Val Arg Arg Gln Arg Gly Arg 
        115                 120                 125             


Arg Asp Arg Leu Ser Arg His Asn Ser Ile Ser Gln Asp Glu Asn Tyr 
    130                 135                 140                 


His His Leu Pro Tyr Ala Gln Gln Gln Ala Ile Glu Glu Pro Arg Ala 
145                 150                 155                 160 


Phe His Pro Pro Asn Val Ser Pro Arg Leu Leu His Pro Ala Ala His 
                165                 170                 175     


Pro Pro Gln Gln Asn Ala Val Met Val Asp Ile His Asp Gln Leu His 
            180                 185                 190         


Gln Gly Thr Val Pro Val Ser Tyr Thr Val Thr Thr Val Ala Pro His 
        195                 200                 205             


Gly Ile Pro Leu Cys Thr Gly Gln His Ile Pro Ala Cys Ser Thr Gln 
    210                 215                 220                 


Gln Val Pro Gly Cys Ser Val Val Phe Ser Gly Gln His Leu Pro Val 
225                 230                 235                 240 


Cys Ser Val Pro Pro Pro Met Leu Gln Ala Cys Ser Val Gln His Leu 
                245                 250                 255     


Pro Val Pro Tyr Ala Ala Phe Pro Pro Leu Ile Ser Ser Asp Pro Phe 
            260                 265                 270         


Leu Ile His Pro Pro His Leu Ser Pro His His Pro Pro His Leu Pro 
        275                 280                 285             


Pro Pro Gly Gln Phe Val Pro Phe Gln Thr Gln Gln Ser Arg Ser Pro 
    290                 295                 300                 


Leu Gln Arg Ile Glu Asn Glu Val Glu Leu Leu Gly Glu His Leu Pro 
305                 310                 315                 320 


Val Gly Gly Phe Thr Tyr Pro Pro Ser Ala His Pro Pro Thr Leu Pro 
                325                 330                 335     


Pro Ser Ala Pro Leu Gln Phe Leu Thr His Asp Pro Leu His Gln Glu 
            340                 345                 350         


Val Ser Phe Gly Val Pro Tyr Pro Pro Phe Met Pro Arg Arg Leu Thr 
        355                 360                 365             


Gly Arg Ser Arg Tyr Arg Ser Gln Gln Pro Ile Pro Pro Pro Pro Tyr 
    370                 375                 380                 


His Pro Ser Leu Leu Pro Tyr Val Leu Ser Met Leu Pro Val Pro Pro 
385                 390                 395                 400 


Ala Val Gly Pro Thr Phe Ser Phe Glu Leu Asp Val Glu Asp Gly Glu 
                405                 410                 415     


Val Glu Asn Tyr Glu Ala Leu Leu Asn Leu Ala Glu Arg Leu Gly Glu 
            420                 425                 430         


Ala Lys Pro Arg Gly Leu Thr Lys Ala Asp Ile Glu Gln Leu Pro Ser 
        435                 440                 445             


Tyr Arg Phe Asn Pro Asn Asn His Gln Ser Glu Gln Thr Leu Cys Val 
    450                 455                 460                 


Val Cys Met Cys Asp Phe Glu Ser Arg Gln Leu Leu Arg Val Leu Pro 
465                 470                 475                 480 


Cys Asn His Glu Phe His Ala Lys Cys Val Asp Lys Trp Leu Lys Ala 
                485                 490                 495     


Asn Arg Thr Cys Pro Ile Cys Arg Ala Asp Ala Ser Glu Val His Arg 
            500                 505                 510         


Asp Ser Glu 
        515 


<210>  2347
<211>  5268
<212>  DNA
<213>  Homosapiens

<400>  2347
gcggcggggc gcggcggggc ggggaggggc gtggccgggc cgggccccta gtgcggtgtt     60

gcgggacggg gccgaggccc ggtcggttgg ggcgtggggg cggagaggat ggagcctccg    120

aggcgttagg cgactctgtc atctctgggc gtgcagccgt cgtttcctgg cgcggcccgt    180

gtgatggtgc cgggaggaag gaagcgcagt gacagtgcct aagttggagc cggggttccg    240

ggggtgagga ggcccgcgga cggcggatct ggcgagctgg ccgcgggctg ggcgagcagt    300

cacaatagga ggcggcggcc cagcgaggat ccgcgggagc tgcccggcag ggcggagcct    360

cccctcgcag atatctcccg gggccaattc agcatctcta cctggccatc ctaacaaggt    420

gatttgtgaa agggtgagac ttcagagcct gttccctctc ctcccaagtg atcagaacac    480

taccgttcaa gaggatgctc acttcaaagc tttcttccag agtgaagata gtccaagtcc    540

taagagacag cgcctctctc attcagtctt tgattataca tcagcatcac cagctccctc    600

accaccaatg cgaccatggg agatgacatc aaataggcag cccccttcag ttcgaccaag    660

ccaacatcac ttctcagggg aacgatgcaa cacacctgca cgcaacagaa gaagtcctcc    720

tgtcaggcgc cagagaggaa gaagggatcg tctgtctcga cataattcca ttagtcaaga    780

tgaaaactat caccatctcc cttacgcaca gcagcaagca atagaggagc ctcgagcctt    840

ccaccctccg aatgtatctc cccgtctgct acatcctgct gctcatccac cccagcagaa    900

tgcagtcatg gttgacatac atgatcagct ccatcaagga acagtccctg tttcttacac    960

agtaacaaca gtggcaccac atgggattcc actctgcaca ggccagcaca tccctgcttg   1020

tagtacacag caggtcccag gatgctctgt ggttttcagt ggacagcacc tccctgtctg   1080

tagtgtgcct cctccaatgc ttcaggcatg ttcagttcag cacttaccag taccatatgc   1140

tgcattccca ccccttattt ctagtgatcc atttcttata catcctcctc acctttctcc   1200

ccatcatcct cctcatttgc caccaccagg ccagtttgtc cctttccaaa cacagcaatc   1260

acgatcgcct ctgcaaagga tagaaaatga agtggaactc ttaggagaac atcttccagt   1320

aggaggtttt acttaccctc catcagccca ccccccaaca ttacctccat cagctccctt   1380

gcagttctta acacatgatc ctttgcatca ggaggtgtcc tttggagtac cttatcctcc   1440

atttatgcct cggaggctta caggacgtag tagataccga tcccagcagc caataccacc   1500

tcccccttat catcccagct tactgccata tgtgttatca atgcttccag tgccacctgc   1560

agtgggccca actttcagct ttgaattaga tgtagaagat ggagaagtag aaaattacga   1620

ggccctgtta aacctggcag agcgactggg agaggcaaag cctcgtggac tgactaaagc   1680

agatattgaa caacttcctt cttatcggtt caatcctaac aaccaccagt cagaacagac   1740

tttgtgtgta gtatgcatgt gtgattttga gtcaaggcag ctacttagag tcttaccctg   1800

taaccacgag ttccatgcca agtgtgttga caaatggctt aaggcaaatc gtacttgccc   1860

aatttgccga gctgatgctt cagaagtgca tcgggattca gaatgaccaa cctaagaagc   1920

acaaatttag tttgggtgtt cctcatcaca tgtatatacg gactatccat tgaacttaat   1980

ctgtgtggct tccagccctc cctttaccaa aagggtcaat ggacctttct ttgcactgtg   2040

tgacttaatc aactataaaa gcttacaatt agtcttcaca gttatgggat tgttatacta   2100

accgtgtgat tggaactcca aagacttttt ctttagctta attttgtgtg tgcactaaca   2160

ttccctggtt tttgtgtgat cattccgagt gttgctgcaa gattacagtg gacgtgatct   2220

tttagcatgt gcttttataa aaagtggtag ctacagatga tatagcaatc taccttatat   2280

agagccttca gaaactgtga gtggaaatga atgcgcagcg tatgactgtt ggtgataagt   2340

gtatctgtgt gagtgtgtgc aactacttgt gtgagggcat ggtagctaac gtgtgtatga   2400

gatcctatat accagcatgt accaagaatg tgtgtgtagt tttaattatg ctgcaatgta   2460

taatctggtg tgttatttaa acagcactag tactgtacac tggttttttt cccttgtgtt   2520

tgctgttgca cactgattgc tgagggtgca tcaattacaa gcattgaata ctccatcccc   2580

ttccctccca gtgaatggaa tgagaaaagc cttcttcctt tgcttcaggc agctgtcacc   2640

ttctctttat tggtggtcct aagtgggtca cttaagaaaa aaaagtgtaa caaattctcg   2700

ctccatgaac ctggtttttt tttattctgt tgtggaaatt tttaaatctc caacttgctg   2760

tttccaaaaa gaaggtgcaa tatcatatat catcagttag caatattagc atttcaatca   2820

gtgatttgaa tgttgatact tttttttcct ttacatttcc agtaagtttc ttacagaaag   2880

tacctgtgat tttttttaat gtttagattt gtagtctagt ctattctgaa gatatttgat   2940

taatatattt ctaagaagac cactagtccc atgaagtctc accttgttga cttccaccag   3000

aacaaaacct gttaattcag cttgacttct catatgtgtt ctgtgttcaa gctcctgtgg   3060

gcaactcaat tgttttaaga aaactctatt tctgttcata ttaattcact tgccagactc   3120

caattctgaa agttgtctag ttcttccttc atcacacgtg cttctcatcg aaaccctggt   3180

ttcaggatgg atcaagtgct gttacagctc atgttcctta gacctgattt gttttgatat   3240

tttactgcct ttccttttaa tttttgtttg aatgagaaaa gtttaataca acaggtgtcc   3300

agaatacttg cagtataaat gaagatttgg tttttgtata aaaaaataat gctgttaaac   3360

aggagttgac cttcatttag ttgatgtaat acatagctgt atggggtttt ttttagtaag   3420

ttctttgagc ataattcact ttaaagtcat ttttccagca atgtttaaat tactttctca   3480

ttcttttagt gtattcaaca ttgtctgcct cttcctgcag ttgatgtaat tgctttgttt   3540

gcaatagcac aagctgcatt attccagtca ggactgtgat aacttgctgc cagccccact   3600

caactttcag ttggctctgt gtcagttttc cattcagtgt taactacttg ttactgccat   3660

gctgcttgcc ctcccttgaa gtgtctataa gctcatcaca gcctagagtt aagtaaagtc   3720

aattcacaga agcacaattt tgccctttgc gagacattgt tgcctctatc tagtcctaca   3780

agtagggttt tgcatactgt gtttgcccct agggttgtca gtgcatcaga aatacttcta   3840

aatagtggta aaaatgcaca tggttaatgc acatgttact tttaaatcat taggatatcc   3900

ctcacctgtt cctgatgaat aaaaagtgtg ttaaagacca aaattcttgg cataataatc   3960

agctacatac aaatcacata tagtttaatc ttttttaatg aaaaaaaatc atgtttaaaa   4020

tggcaaaagc ccatcttata cacttttata tagctgcaaa aaatttatat ctgtacagat   4080

ctaacactac gacactcagt attcatttta ttgaagcatg caagtaaagc actttttcta   4140

atttatatag aggtatctaa ttaacacagc acattgtact aatgactagg agtagcagct   4200

ttttcttctc tccctctatg aattcttata atgtcccttt ttctgtaagt ttttgagagg   4260

caattggcaa tttaggaggc agcagggtct gttttggtca aatcttgaat ttcgttgttg   4320

cactctagtg actgatcttt gggaatgtct tgtctttgca tggggctcat agagatgtgt   4380

gcagacttgc ttattgtggt tagtgtgtat caggaacaca cacacaggtg ttctgaccag   4440

ctcaggcttg ccacagtgag caactctgtg gctagcaaaa gagaagttta tttgtgccca   4500

gccattggtc accttgggtg atgcaccaga tagcaggcag atgttggttc attggccttc   4560

gtcctctttc ctcctaaaat aatattggct ttaccatctt aactcagctg tgggtttttt   4620

gtgggttctt gtttgttttt tggcatgaat tgtcatcttt ggtgtttttt taacccccag   4680

cccctcaaaa aaataaggcc tccaggtatc aagatctcat attaggattt tctgtcctta   4740

attttttgag caaaatctgg aaaatgtgaa agcatattta gattttatat actatctgaa   4800

atgtgatttg ttaagattct taaatttggg cctcttagaa taattttgaa tgagatctac   4860

cgactcactt gtgagaatat ttttcacaga ttatctttgg gccttttcat tagaaagctg   4920

tttgtttgtc cccctgttgg tacatttggt tacctcattt tgccgtttca gattgtgaaa   4980

gctcacaggg gtgttttttg gaatcatttg ctgagtcatt ttctcaaatc atattccatt   5040

gtatcagtta acatatagtt ttaaatgtat gtattataaa tatctgtaac caaatcattt   5100

gaaggcttga taaattttta acaaagtttg tacatttttt atgaaagtta ctagtaatgc   5160

tttactaagt agtgcaatga atttttattt ttaatccctg tgcccaattt tggagttgag   5220

agggttgttg gtaataaatg tatgatgtac acttaaaaaa aaaaaaaa                5268


<210>  2348
<211>  432
<212>  PRT
<213>  Homosapiens

<400>  2348

Met Arg Pro Trp Glu Met Thr Ser Asn Arg Gln Pro Pro Ser Val Arg 
1               5                   10                  15      


Pro Ser Gln His His Phe Ser Gly Glu Arg Cys Asn Thr Pro Ala Arg 
            20                  25                  30          


Asn Arg Arg Ser Pro Pro Val Arg Arg Gln Arg Gly Arg Arg Asp Arg 
        35                  40                  45              


Leu Ser Arg His Asn Ser Ile Ser Gln Asp Glu Asn Tyr His His Leu 
    50                  55                  60                  


Pro Tyr Ala Gln Gln Gln Ala Ile Glu Glu Pro Arg Ala Phe His Pro 
65                  70                  75                  80  


Pro Asn Val Ser Pro Arg Leu Leu His Pro Ala Ala His Pro Pro Gln 
                85                  90                  95      


Gln Asn Ala Val Met Val Asp Ile His Asp Gln Leu His Gln Gly Thr 
            100                 105                 110         


Val Pro Val Ser Tyr Thr Val Thr Thr Val Ala Pro His Gly Ile Pro 
        115                 120                 125             


Leu Cys Thr Gly Gln His Ile Pro Ala Cys Ser Thr Gln Gln Val Pro 
    130                 135                 140                 


Gly Cys Ser Val Val Phe Ser Gly Gln His Leu Pro Val Cys Ser Val 
145                 150                 155                 160 


Pro Pro Pro Met Leu Gln Ala Cys Ser Val Gln His Leu Pro Val Pro 
                165                 170                 175     


Tyr Ala Ala Phe Pro Pro Leu Ile Ser Ser Asp Pro Phe Leu Ile His 
            180                 185                 190         


Pro Pro His Leu Ser Pro His His Pro Pro His Leu Pro Pro Pro Gly 
        195                 200                 205             


Gln Phe Val Pro Phe Gln Thr Gln Gln Ser Arg Ser Pro Leu Gln Arg 
    210                 215                 220                 


Ile Glu Asn Glu Val Glu Leu Leu Gly Glu His Leu Pro Val Gly Gly 
225                 230                 235                 240 


Phe Thr Tyr Pro Pro Ser Ala His Pro Pro Thr Leu Pro Pro Ser Ala 
                245                 250                 255     


Pro Leu Gln Phe Leu Thr His Asp Pro Leu His Gln Glu Val Ser Phe 
            260                 265                 270         


Gly Val Pro Tyr Pro Pro Phe Met Pro Arg Arg Leu Thr Gly Arg Ser 
        275                 280                 285             


Arg Tyr Arg Ser Gln Gln Pro Ile Pro Pro Pro Pro Tyr His Pro Ser 
    290                 295                 300                 


Leu Leu Pro Tyr Val Leu Ser Met Leu Pro Val Pro Pro Ala Val Gly 
305                 310                 315                 320 


Pro Thr Phe Ser Phe Glu Leu Asp Val Glu Asp Gly Glu Val Glu Asn 
                325                 330                 335     


Tyr Glu Ala Leu Leu Asn Leu Ala Glu Arg Leu Gly Glu Ala Lys Pro 
            340                 345                 350         


Arg Gly Leu Thr Lys Ala Asp Ile Glu Gln Leu Pro Ser Tyr Arg Phe 
        355                 360                 365             


Asn Pro Asn Asn His Gln Ser Glu Gln Thr Leu Cys Val Val Cys Met 
    370                 375                 380                 


Cys Asp Phe Glu Ser Arg Gln Leu Leu Arg Val Leu Pro Cys Asn His 
385                 390                 395                 400 


Glu Phe His Ala Lys Cys Val Asp Lys Trp Leu Lys Ala Asn Arg Thr 
                405                 410                 415     


Cys Pro Ile Cys Arg Ala Asp Ala Ser Glu Val His Arg Asp Ser Glu 
            420                 425                 430         


<210>  2349
<211>  4951
<212>  DNA
<213>  Homosapiens

<400>  2349
cggaacccgg tcgaaagggt cctctctggc gtccttctgc ttccgtgggt ttctggatag     60

gctgcgtttt gttctcaggg gatgcaagtt cttcctttca gggttgaagc gtgagagagg    120

ttggtttttg aaacgggagt gtttcaggtt attgaggtcc aaaaagaaat aaagtttttg    180

tttacgtctg tatggcttgt aagagtgaag atagtccaag tcctaagaga cagcgcctct    240

ctcattcagt ctttgattat acatcagcat caccagctcc ctcaccacca atgcgaccat    300

gggagatgac atcaaatagg cagccccctt cagttcgacc aagccaacat cacttctcag    360

gggaacgatg caacacacct gcacgcaaca gaagaagtcc tcctgtcagg cgccagagag    420

gaagaaggga tcgtctgtct cgacataatt ccattagtca agatgaaaac tatcaccatc    480

tcccttacgc acagcagcaa gcaatagagg agcctcgagc cttccaccct ccgaatgtat    540

ctccccgtct gctacatcct gctgctcatc caccccagca gaatgcagtc atggttgaca    600

tacatgatca gctccatcaa ggaacagtcc ctgtttctta cacagtaaca acagtggcac    660

cacatgggat tccactctgc acaggccagc acatccctgc ttgtagtaca cagcaggtcc    720

caggatgctc tgtggttttc agtggacagc acctccctgt ctgtagtgtg cctcctccaa    780

tgcttcaggc atgttcagtt cagcacttac cagtaccata tgctgcattc ccacccctta    840

tttctagtga tccatttctt atacatcctc ctcacctttc tccccatcat cctcctcatt    900

tgccaccacc aggccagttt gtccctttcc aaacacagca atcacgatcg cctctgcaaa    960

ggatagaaaa tgaagtggaa ctcttaggag aacatcttcc agtaggaggt tttacttacc   1020

ctccatcagc ccacccccca acattacctc catcagctcc cttgcagttc ttaacacatg   1080

atcctttgca tcaggaggtg tcctttggag taccttatcc tccatttatg cctcggaggc   1140

ttacaggacg tagtagatac cgatcccagc agccaatacc acctccccct tatcatccca   1200

gcttactgcc atatgtgtta tcaatgcttc cagtgccacc tgcagtgggc ccaactttca   1260

gctttgaatt agatgtagaa gatggagaag tagaaaatta cgaggccctg ttaaacctgg   1320

cagagcgact gggagaggca aagcctcgtg gactgactaa agcagatatt gaacaacttc   1380

cttcttatcg gttcaatcct aacaaccacc agtcagaaca gactttgtgt gtagtatgca   1440

tgtgtgattt tgagtcaagg cagctactta gagtcttacc ctgtaaccac gagttccatg   1500

ccaagtgtgt tgacaaatgg cttaaggcaa atcgtacttg cccaatttgc cgagctgatg   1560

cttcagaagt gcatcgggat tcagaatgac caacctaaga agcacaaatt tagtttgggt   1620

gttcctcatc acatgtatat acggactatc cattgaactt aatctgtgtg gcttccagcc   1680

ctccctttac caaaagggtc aatggacctt tctttgcact gtgtgactta atcaactata   1740

aaagcttaca attagtcttc acagttatgg gattgttata ctaaccgtgt gattggaact   1800

ccaaagactt tttctttagc ttaattttgt gtgtgcacta acattccctg gtttttgtgt   1860

gatcattccg agtgttgctg caagattaca gtggacgtga tcttttagca tgtgctttta   1920

taaaaagtgg tagctacaga tgatatagca atctacctta tatagagcct tcagaaactg   1980

tgagtggaaa tgaatgcgca gcgtatgact gttggtgata agtgtatctg tgtgagtgtg   2040

tgcaactact tgtgtgaggg catggtagct aacgtgtgta tgagatccta tataccagca   2100

tgtaccaaga atgtgtgtgt agttttaatt atgctgcaat gtataatctg gtgtgttatt   2160

taaacagcac tagtactgta cactggtttt tttcccttgt gtttgctgtt gcacactgat   2220

tgctgagggt gcatcaatta caagcattga atactccatc cccttccctc ccagtgaatg   2280

gaatgagaaa agccttcttc ctttgcttca ggcagctgtc accttctctt tattggtggt   2340

cctaagtggg tcacttaaga aaaaaaagtg taacaaattc tcgctccatg aacctggttt   2400

ttttttattc tgttgtggaa atttttaaat ctccaacttg ctgtttccaa aaagaaggtg   2460

caatatcata tatcatcagt tagcaatatt agcatttcaa tcagtgattt gaatgttgat   2520

actttttttt cctttacatt tccagtaagt ttcttacaga aagtacctgt gatttttttt   2580

aatgtttaga tttgtagtct agtctattct gaagatattt gattaatata tttctaagaa   2640

gaccactagt cccatgaagt ctcaccttgt tgacttccac cagaacaaaa cctgttaatt   2700

cagcttgact tctcatatgt gttctgtgtt caagctcctg tgggcaactc aattgtttta   2760

agaaaactct atttctgttc atattaattc acttgccaga ctccaattct gaaagttgtc   2820

tagttcttcc ttcatcacac gtgcttctca tcgaaaccct ggtttcagga tggatcaagt   2880

gctgttacag ctcatgttcc ttagacctga tttgttttga tattttactg cctttccttt   2940

taatttttgt ttgaatgaga aaagtttaat acaacaggtg tccagaatac ttgcagtata   3000

aatgaagatt tggtttttgt ataaaaaaat aatgctgtta aacaggagtt gaccttcatt   3060

tagttgatgt aatacatagc tgtatggggt tttttttagt aagttctttg agcataattc   3120

actttaaagt catttttcca gcaatgttta aattactttc tcattctttt agtgtattca   3180

acattgtctg cctcttcctg cagttgatgt aattgctttg tttgcaatag cacaagctgc   3240

attattccag tcaggactgt gataacttgc tgccagcccc actcaacttt cagttggctc   3300

tgtgtcagtt ttccattcag tgttaactac ttgttactgc catgctgctt gccctccctt   3360

gaagtgtcta taagctcatc acagcctaga gttaagtaaa gtcaattcac agaagcacaa   3420

ttttgccctt tgcgagacat tgttgcctct atctagtcct acaagtaggg ttttgcatac   3480

tgtgtttgcc cctagggttg tcagtgcatc agaaatactt ctaaatagtg gtaaaaatgc   3540

acatggttaa tgcacatgtt acttttaaat cattaggata tccctcacct gttcctgatg   3600

aataaaaagt gtgttaaaga ccaaaattct tggcataata atcagctaca tacaaatcac   3660

atatagttta atctttttta atgaaaaaaa atcatgttta aaatggcaaa agcccatctt   3720

atacactttt atatagctgc aaaaaattta tatctgtaca gatctaacac tacgacactc   3780

agtattcatt ttattgaagc atgcaagtaa agcacttttt ctaatttata tagaggtatc   3840

taattaacac agcacattgt actaatgact aggagtagca gctttttctt ctctccctct   3900

atgaattctt ataatgtccc tttttctgta agtttttgag aggcaattgg caatttagga   3960

ggcagcaggg tctgttttgg tcaaatcttg aatttcgttg ttgcactcta gtgactgatc   4020

tttgggaatg tcttgtcttt gcatggggct catagagatg tgtgcagact tgcttattgt   4080

ggttagtgtg tatcaggaac acacacacag gtgttctgac cagctcaggc ttgccacagt   4140

gagcaactct gtggctagca aaagagaagt ttatttgtgc ccagccattg gtcaccttgg   4200

gtgatgcacc agatagcagg cagatgttgg ttcattggcc ttcgtcctct ttcctcctaa   4260

aataatattg gctttaccat cttaactcag ctgtgggttt tttgtgggtt cttgtttgtt   4320

ttttggcatg aattgtcatc tttggtgttt ttttaacccc cagcccctca aaaaaataag   4380

gcctccaggt atcaagatct catattagga ttttctgtcc ttaatttttt gagcaaaatc   4440

tggaaaatgt gaaagcatat ttagatttta tatactatct gaaatgtgat ttgttaagat   4500

tcttaaattt gggcctctta gaataatttt gaatgagatc taccgactca cttgtgagaa   4560

tatttttcac agattatctt tgggcctttt cattagaaag ctgtttgttt gtccccctgt   4620

tggtacattt ggttacctca ttttgccgtt tcagattgtg aaagctcaca ggggtgtttt   4680

ttggaatcat ttgctgagtc attttctcaa atcatattcc attgtatcag ttaacatata   4740

gttttaaatg tatgtattat aaatatctgt aaccaaatca tttgaaggct tgataaattt   4800

ttaacaaagt ttgtacattt tttatgaaag ttactagtaa tgctttacta agtagtgcaa   4860

tgaattttta tttttaatcc ctgtgcccaa ttttggagtt gagagggttg ttggtaataa   4920

atgtatgatg tacacttaaa aaaaaaaaaa a                                  4951


<210>  2350
<211>  465
<212>  PRT
<213>  Homosapiens

<400>  2350

Met Ala Cys Lys Ser Glu Asp Ser Pro Ser Pro Lys Arg Gln Arg Leu 
1               5                   10                  15      


Ser His Ser Val Phe Asp Tyr Thr Ser Ala Ser Pro Ala Pro Ser Pro 
            20                  25                  30          


Pro Met Arg Pro Trp Glu Met Thr Ser Asn Arg Gln Pro Pro Ser Val 
        35                  40                  45              


Arg Pro Ser Gln His His Phe Ser Gly Glu Arg Cys Asn Thr Pro Ala 
    50                  55                  60                  


Arg Asn Arg Arg Ser Pro Pro Val Arg Arg Gln Arg Gly Arg Arg Asp 
65                  70                  75                  80  


Arg Leu Ser Arg His Asn Ser Ile Ser Gln Asp Glu Asn Tyr His His 
                85                  90                  95      


Leu Pro Tyr Ala Gln Gln Gln Ala Ile Glu Glu Pro Arg Ala Phe His 
            100                 105                 110         


Pro Pro Asn Val Ser Pro Arg Leu Leu His Pro Ala Ala His Pro Pro 
        115                 120                 125             


Gln Gln Asn Ala Val Met Val Asp Ile His Asp Gln Leu His Gln Gly 
    130                 135                 140                 


Thr Val Pro Val Ser Tyr Thr Val Thr Thr Val Ala Pro His Gly Ile 
145                 150                 155                 160 


Pro Leu Cys Thr Gly Gln His Ile Pro Ala Cys Ser Thr Gln Gln Val 
                165                 170                 175     


Pro Gly Cys Ser Val Val Phe Ser Gly Gln His Leu Pro Val Cys Ser 
            180                 185                 190         


Val Pro Pro Pro Met Leu Gln Ala Cys Ser Val Gln His Leu Pro Val 
        195                 200                 205             


Pro Tyr Ala Ala Phe Pro Pro Leu Ile Ser Ser Asp Pro Phe Leu Ile 
    210                 215                 220                 


His Pro Pro His Leu Ser Pro His His Pro Pro His Leu Pro Pro Pro 
225                 230                 235                 240 


Gly Gln Phe Val Pro Phe Gln Thr Gln Gln Ser Arg Ser Pro Leu Gln 
                245                 250                 255     


Arg Ile Glu Asn Glu Val Glu Leu Leu Gly Glu His Leu Pro Val Gly 
            260                 265                 270         


Gly Phe Thr Tyr Pro Pro Ser Ala His Pro Pro Thr Leu Pro Pro Ser 
        275                 280                 285             


Ala Pro Leu Gln Phe Leu Thr His Asp Pro Leu His Gln Glu Val Ser 
    290                 295                 300                 


Phe Gly Val Pro Tyr Pro Pro Phe Met Pro Arg Arg Leu Thr Gly Arg 
305                 310                 315                 320 


Ser Arg Tyr Arg Ser Gln Gln Pro Ile Pro Pro Pro Pro Tyr His Pro 
                325                 330                 335     


Ser Leu Leu Pro Tyr Val Leu Ser Met Leu Pro Val Pro Pro Ala Val 
            340                 345                 350         


Gly Pro Thr Phe Ser Phe Glu Leu Asp Val Glu Asp Gly Glu Val Glu 
        355                 360                 365             


Asn Tyr Glu Ala Leu Leu Asn Leu Ala Glu Arg Leu Gly Glu Ala Lys 
    370                 375                 380                 


Pro Arg Gly Leu Thr Lys Ala Asp Ile Glu Gln Leu Pro Ser Tyr Arg 
385                 390                 395                 400 


Phe Asn Pro Asn Asn His Gln Ser Glu Gln Thr Leu Cys Val Val Cys 
                405                 410                 415     


Met Cys Asp Phe Glu Ser Arg Gln Leu Leu Arg Val Leu Pro Cys Asn 
            420                 425                 430         


His Glu Phe His Ala Lys Cys Val Asp Lys Trp Leu Lys Ala Asn Arg 
        435                 440                 445             


Thr Cys Pro Ile Cys Arg Ala Asp Ala Ser Glu Val His Arg Asp Ser 
    450                 455                 460                 


Glu 
465 


<210>  2351
<211>  4999
<212>  DNA
<213>  Homosapiens

<400>  2351
cttccccctc ggggtggaaa caaagggggt tcggcgcgcg gtgcggagcc tgggggaaaa     60

gggaggagcg ctccggtggt ctggcgcgct gggctcgcta gatatctccc ggggccaatt    120

cagcatctct acctggccat cctaacaagg tgatttgtga aagggtgaga cttcagagcc    180

tgttccctct cctcccaagt gatcagaaca ctaccgttca agaggatgct cacttcaaag    240

ctttcttcca gagtgaagat agtccaagtc ctaagagaca gcgcctctct cattcagtct    300

ttgattatac atcagcatca ccagctccct caccaccaat gcgaccatgg gagatgacat    360

caaataggca gcccccttca gttcgaccaa gccaacatca cttctcaggg gaacgatgca    420

acacacctgc acgcaacaga agaagtcctc ctgtcaggcg ccagagagga agaagggatc    480

gtctgtctcg acataattcc attagtcaag atgaaaacta tcaccatctc ccttacgcac    540

agcagcaagc aatagaggag cctcgagcct tccaccctcc gaatgtatct ccccgtctgc    600

tacatcctgc tgctcatcca ccccagcaga atgcagtcat ggttgacata catgatcagc    660

tccatcaagg aacagtccct gtttcttaca cagtaacaac agtggcacca catgggattc    720

cactctgcac aggccagcac atccctgctt gtagtacaca gcaggtccca ggatgctctg    780

tggttttcag tggacagcac ctccctgtct gtagtgtgcc tcctccaatg cttcaggcat    840

gttcagttca gcacttacca gtaccatatg ctgcattccc accccttatt tctagtgatc    900

catttcttat acatcctcct cacctttctc cccatcatcc tcctcatttg ccaccaccag    960

gccagtttgt ccctttccaa acacagcaat cacgatcgcc tctgcaaagg atagaaaatg   1020

aagtggaact cttaggagaa catcttccag taggaggttt tacttaccct ccatcagccc   1080

accccccaac attacctcca tcagctccct tgcagttctt aacacatgat cctttgcatc   1140

aggaggtgtc ctttggagta ccttatcctc catttatgcc tcggaggctt acaggacgta   1200

gtagataccg atcccagcag ccaataccac ctccccctta tcatcccagc ttactgccat   1260

atgtgttatc aatgcttcca gtgccacctg cagtgggccc aactttcagc tttgaattag   1320

atgtagaaga tggagaagta gaaaattacg aggccctgtt aaacctggca gagcgactgg   1380

gagaggcaaa gcctcgtgga ctgactaaag cagatattga acaacttcct tcttatcggt   1440

tcaatcctaa caaccaccag tcagaacaga ctttgtgtgt agtatgcatg tgtgattttg   1500

agtcaaggca gctacttaga gtcttaccct gtaaccacga gttccatgcc aagtgtgttg   1560

acaaatggct taaggcaaat cgtacttgcc caatttgccg agctgatgct tcagaagtgc   1620

atcgggattc agaatgacca acctaagaag cacaaattta gtttgggtgt tcctcatcac   1680

atgtatatac ggactatcca ttgaacttaa tctgtgtggc ttccagccct ccctttacca   1740

aaagggtcaa tggacctttc tttgcactgt gtgacttaat caactataaa agcttacaat   1800

tagtcttcac agttatggga ttgttatact aaccgtgtga ttggaactcc aaagactttt   1860

tctttagctt aattttgtgt gtgcactaac attccctggt ttttgtgtga tcattccgag   1920

tgttgctgca agattacagt ggacgtgatc ttttagcatg tgcttttata aaaagtggta   1980

gctacagatg atatagcaat ctaccttata tagagccttc agaaactgtg agtggaaatg   2040

aatgcgcagc gtatgactgt tggtgataag tgtatctgtg tgagtgtgtg caactacttg   2100

tgtgagggca tggtagctaa cgtgtgtatg agatcctata taccagcatg taccaagaat   2160

gtgtgtgtag ttttaattat gctgcaatgt ataatctggt gtgttattta aacagcacta   2220

gtactgtaca ctggtttttt tcccttgtgt ttgctgttgc acactgattg ctgagggtgc   2280

atcaattaca agcattgaat actccatccc cttccctccc agtgaatgga atgagaaaag   2340

ccttcttcct ttgcttcagg cagctgtcac cttctcttta ttggtggtcc taagtgggtc   2400

acttaagaaa aaaaagtgta acaaattctc gctccatgaa cctggttttt ttttattctg   2460

ttgtggaaat ttttaaatct ccaacttgct gtttccaaaa agaaggtgca atatcatata   2520

tcatcagtta gcaatattag catttcaatc agtgatttga atgttgatac ttttttttcc   2580

tttacatttc cagtaagttt cttacagaaa gtacctgtga ttttttttaa tgtttagatt   2640

tgtagtctag tctattctga agatatttga ttaatatatt tctaagaaga ccactagtcc   2700

catgaagtct caccttgttg acttccacca gaacaaaacc tgttaattca gcttgacttc   2760

tcatatgtgt tctgtgttca agctcctgtg ggcaactcaa ttgttttaag aaaactctat   2820

ttctgttcat attaattcac ttgccagact ccaattctga aagttgtcta gttcttcctt   2880

catcacacgt gcttctcatc gaaaccctgg tttcaggatg gatcaagtgc tgttacagct   2940

catgttcctt agacctgatt tgttttgata ttttactgcc tttcctttta atttttgttt   3000

gaatgagaaa agtttaatac aacaggtgtc cagaatactt gcagtataaa tgaagatttg   3060

gtttttgtat aaaaaaataa tgctgttaaa caggagttga ccttcattta gttgatgtaa   3120

tacatagctg tatggggttt tttttagtaa gttctttgag cataattcac tttaaagtca   3180

tttttccagc aatgtttaaa ttactttctc attcttttag tgtattcaac attgtctgcc   3240

tcttcctgca gttgatgtaa ttgctttgtt tgcaatagca caagctgcat tattccagtc   3300

aggactgtga taacttgctg ccagccccac tcaactttca gttggctctg tgtcagtttt   3360

ccattcagtg ttaactactt gttactgcca tgctgcttgc cctcccttga agtgtctata   3420

agctcatcac agcctagagt taagtaaagt caattcacag aagcacaatt ttgccctttg   3480

cgagacattg ttgcctctat ctagtcctac aagtagggtt ttgcatactg tgtttgcccc   3540

tagggttgtc agtgcatcag aaatacttct aaatagtggt aaaaatgcac atggttaatg   3600

cacatgttac ttttaaatca ttaggatatc cctcacctgt tcctgatgaa taaaaagtgt   3660

gttaaagacc aaaattcttg gcataataat cagctacata caaatcacat atagtttaat   3720

cttttttaat gaaaaaaaat catgtttaaa atggcaaaag cccatcttat acacttttat   3780

atagctgcaa aaaatttata tctgtacaga tctaacacta cgacactcag tattcatttt   3840

attgaagcat gcaagtaaag cactttttct aatttatata gaggtatcta attaacacag   3900

cacattgtac taatgactag gagtagcagc tttttcttct ctccctctat gaattcttat   3960

aatgtccctt tttctgtaag tttttgagag gcaattggca atttaggagg cagcagggtc   4020

tgttttggtc aaatcttgaa tttcgttgtt gcactctagt gactgatctt tgggaatgtc   4080

ttgtctttgc atggggctca tagagatgtg tgcagacttg cttattgtgg ttagtgtgta   4140

tcaggaacac acacacaggt gttctgacca gctcaggctt gccacagtga gcaactctgt   4200

ggctagcaaa agagaagttt atttgtgccc agccattggt caccttgggt gatgcaccag   4260

atagcaggca gatgttggtt cattggcctt cgtcctcttt cctcctaaaa taatattggc   4320

tttaccatct taactcagct gtgggttttt tgtgggttct tgtttgtttt ttggcatgaa   4380

ttgtcatctt tggtgttttt ttaaccccca gcccctcaaa aaaataaggc ctccaggtat   4440

caagatctca tattaggatt ttctgtcctt aattttttga gcaaaatctg gaaaatgtga   4500

aagcatattt agattttata tactatctga aatgtgattt gttaagattc ttaaatttgg   4560

gcctcttaga ataattttga atgagatcta ccgactcact tgtgagaata tttttcacag   4620

attatctttg ggccttttca ttagaaagct gtttgtttgt ccccctgttg gtacatttgg   4680

ttacctcatt ttgccgtttc agattgtgaa agctcacagg ggtgtttttt ggaatcattt   4740

gctgagtcat tttctcaaat catattccat tgtatcagtt aacatatagt tttaaatgta   4800

tgtattataa atatctgtaa ccaaatcatt tgaaggcttg ataaattttt aacaaagttt   4860

gtacattttt tatgaaagtt actagtaatg ctttactaag tagtgcaatg aatttttatt   4920

tttaatccct gtgcccaatt ttggagttga gagggttgtt ggtaataaat gtatgatgta   4980

cacttaaaaa aaaaaaaaa                                                4999


<210>  2352
<211>  432
<212>  PRT
<213>  Homosapiens

<400>  2352

Met Arg Pro Trp Glu Met Thr Ser Asn Arg Gln Pro Pro Ser Val Arg 
1               5                   10                  15      


Pro Ser Gln His His Phe Ser Gly Glu Arg Cys Asn Thr Pro Ala Arg 
            20                  25                  30          


Asn Arg Arg Ser Pro Pro Val Arg Arg Gln Arg Gly Arg Arg Asp Arg 
        35                  40                  45              


Leu Ser Arg His Asn Ser Ile Ser Gln Asp Glu Asn Tyr His His Leu 
    50                  55                  60                  


Pro Tyr Ala Gln Gln Gln Ala Ile Glu Glu Pro Arg Ala Phe His Pro 
65                  70                  75                  80  


Pro Asn Val Ser Pro Arg Leu Leu His Pro Ala Ala His Pro Pro Gln 
                85                  90                  95      


Gln Asn Ala Val Met Val Asp Ile His Asp Gln Leu His Gln Gly Thr 
            100                 105                 110         


Val Pro Val Ser Tyr Thr Val Thr Thr Val Ala Pro His Gly Ile Pro 
        115                 120                 125             


Leu Cys Thr Gly Gln His Ile Pro Ala Cys Ser Thr Gln Gln Val Pro 
    130                 135                 140                 


Gly Cys Ser Val Val Phe Ser Gly Gln His Leu Pro Val Cys Ser Val 
145                 150                 155                 160 


Pro Pro Pro Met Leu Gln Ala Cys Ser Val Gln His Leu Pro Val Pro 
                165                 170                 175     


Tyr Ala Ala Phe Pro Pro Leu Ile Ser Ser Asp Pro Phe Leu Ile His 
            180                 185                 190         


Pro Pro His Leu Ser Pro His His Pro Pro His Leu Pro Pro Pro Gly 
        195                 200                 205             


Gln Phe Val Pro Phe Gln Thr Gln Gln Ser Arg Ser Pro Leu Gln Arg 
    210                 215                 220                 


Ile Glu Asn Glu Val Glu Leu Leu Gly Glu His Leu Pro Val Gly Gly 
225                 230                 235                 240 


Phe Thr Tyr Pro Pro Ser Ala His Pro Pro Thr Leu Pro Pro Ser Ala 
                245                 250                 255     


Pro Leu Gln Phe Leu Thr His Asp Pro Leu His Gln Glu Val Ser Phe 
            260                 265                 270         


Gly Val Pro Tyr Pro Pro Phe Met Pro Arg Arg Leu Thr Gly Arg Ser 
        275                 280                 285             


Arg Tyr Arg Ser Gln Gln Pro Ile Pro Pro Pro Pro Tyr His Pro Ser 
    290                 295                 300                 


Leu Leu Pro Tyr Val Leu Ser Met Leu Pro Val Pro Pro Ala Val Gly 
305                 310                 315                 320 


Pro Thr Phe Ser Phe Glu Leu Asp Val Glu Asp Gly Glu Val Glu Asn 
                325                 330                 335     


Tyr Glu Ala Leu Leu Asn Leu Ala Glu Arg Leu Gly Glu Ala Lys Pro 
            340                 345                 350         


Arg Gly Leu Thr Lys Ala Asp Ile Glu Gln Leu Pro Ser Tyr Arg Phe 
        355                 360                 365             


Asn Pro Asn Asn His Gln Ser Glu Gln Thr Leu Cys Val Val Cys Met 
    370                 375                 380                 


Cys Asp Phe Glu Ser Arg Gln Leu Leu Arg Val Leu Pro Cys Asn His 
385                 390                 395                 400 


Glu Phe His Ala Lys Cys Val Asp Lys Trp Leu Lys Ala Asn Arg Thr 
                405                 410                 415     


Cys Pro Ile Cys Arg Ala Asp Ala Ser Glu Val His Arg Asp Ser Glu 
            420                 425                 430         


<210>  2353
<211>  5118
<212>  DNA
<213>  Homosapiens

<400>  2353
gcggcggggc gcggcggggc ggggaggggc gtggccgggc cgggccccta gtgcggtgtt     60

gcgggacggg gccgaggccc ggtcggttgg ggcgtggggg cggagaggat ggagcctccg    120

aggcgttagg cgactctgtc atctctgggc gtgcagccgt cgtttcctgg cgcggcccgt    180

gtgatggtgc cgggaggaag gaagcgcagt gacagtgcct aagttggagc cggggttccg    240

ggggtgagga ggcccgcgga cggcggatct ggcgagctgg ccgcgggctg ggcgagcagt    300

cacaatagga ggcggcggcc cagcgaggat ccgcgggagc tgcccggcag ggcggagcct    360

cccctcgcag agtgaagata gtccaagtcc taagagacag cgcctctctc attcagtctt    420

tgattataca tcagcatcac cagctccctc accaccaatg cgaccatggg agatgacatc    480

aaataggcag cccccttcag ttcgaccaag ccaacatcac ttctcagggg aacgatgcaa    540

cacacctgca cgcaacagaa gaagtcctcc tgtcaggcgc cagagaggaa gaagggatcg    600

tctgtctcga cataattcca ttagtcaaga tgaaaactat caccatctcc cttacgcaca    660

gcagcaagca atagaggagc ctcgagcctt ccaccctccg aatgtatctc cccgtctgct    720

acatcctgct gctcatccac cccagcagaa tgcagtcatg gttgacatac atgatcagct    780

ccatcaagga acagtccctg tttcttacac agtaacaaca gtggcaccac atgggattcc    840

actctgcaca ggccagcaca tccctgcttg tagtacacag caggtcccag gatgctctgt    900

ggttttcagt ggacagcacc tccctgtctg tagtgtgcct cctccaatgc ttcaggcatg    960

ttcagttcag cacttaccag taccatatgc tgcattccca ccccttattt ctagtgatcc   1020

atttcttata catcctcctc acctttctcc ccatcatcct cctcatttgc caccaccagg   1080

ccagtttgtc cctttccaaa cacagcaatc acgatcgcct ctgcaaagga tagaaaatga   1140

agtggaactc ttaggagaac atcttccagt aggaggtttt acttaccctc catcagccca   1200

ccccccaaca ttacctccat cagctccctt gcagttctta acacatgatc ctttgcatca   1260

ggaggtgtcc tttggagtac cttatcctcc atttatgcct cggaggctta caggacgtag   1320

tagataccga tcccagcagc caataccacc tcccccttat catcccagct tactgccata   1380

tgtgttatca atgcttccag tgccacctgc agtgggccca actttcagct ttgaattaga   1440

tgtagaagat ggagaagtag aaaattacga ggccctgtta aacctggcag agcgactggg   1500

agaggcaaag cctcgtggac tgactaaagc agatattgaa caacttcctt cttatcggtt   1560

caatcctaac aaccaccagt cagaacagac tttgtgtgta gtatgcatgt gtgattttga   1620

gtcaaggcag ctacttagag tcttaccctg taaccacgag ttccatgcca agtgtgttga   1680

caaatggctt aaggcaaatc gtacttgccc aatttgccga gctgatgctt cagaagtgca   1740

tcgggattca gaatgaccaa cctaagaagc acaaatttag tttgggtgtt cctcatcaca   1800

tgtatatacg gactatccat tgaacttaat ctgtgtggct tccagccctc cctttaccaa   1860

aagggtcaat ggacctttct ttgcactgtg tgacttaatc aactataaaa gcttacaatt   1920

agtcttcaca gttatgggat tgttatacta accgtgtgat tggaactcca aagacttttt   1980

ctttagctta attttgtgtg tgcactaaca ttccctggtt tttgtgtgat cattccgagt   2040

gttgctgcaa gattacagtg gacgtgatct tttagcatgt gcttttataa aaagtggtag   2100

ctacagatga tatagcaatc taccttatat agagccttca gaaactgtga gtggaaatga   2160

atgcgcagcg tatgactgtt ggtgataagt gtatctgtgt gagtgtgtgc aactacttgt   2220

gtgagggcat ggtagctaac gtgtgtatga gatcctatat accagcatgt accaagaatg   2280

tgtgtgtagt tttaattatg ctgcaatgta taatctggtg tgttatttaa acagcactag   2340

tactgtacac tggttttttt cccttgtgtt tgctgttgca cactgattgc tgagggtgca   2400

tcaattacaa gcattgaata ctccatcccc ttccctccca gtgaatggaa tgagaaaagc   2460

cttcttcctt tgcttcaggc agctgtcacc ttctctttat tggtggtcct aagtgggtca   2520

cttaagaaaa aaaagtgtaa caaattctcg ctccatgaac ctggtttttt tttattctgt   2580

tgtggaaatt tttaaatctc caacttgctg tttccaaaaa gaaggtgcaa tatcatatat   2640

catcagttag caatattagc atttcaatca gtgatttgaa tgttgatact tttttttcct   2700

ttacatttcc agtaagtttc ttacagaaag tacctgtgat tttttttaat gtttagattt   2760

gtagtctagt ctattctgaa gatatttgat taatatattt ctaagaagac cactagtccc   2820

atgaagtctc accttgttga cttccaccag aacaaaacct gttaattcag cttgacttct   2880

catatgtgtt ctgtgttcaa gctcctgtgg gcaactcaat tgttttaaga aaactctatt   2940

tctgttcata ttaattcact tgccagactc caattctgaa agttgtctag ttcttccttc   3000

atcacacgtg cttctcatcg aaaccctggt ttcaggatgg atcaagtgct gttacagctc   3060

atgttcctta gacctgattt gttttgatat tttactgcct ttccttttaa tttttgtttg   3120

aatgagaaaa gtttaataca acaggtgtcc agaatacttg cagtataaat gaagatttgg   3180

tttttgtata aaaaaataat gctgttaaac aggagttgac cttcatttag ttgatgtaat   3240

acatagctgt atggggtttt ttttagtaag ttctttgagc ataattcact ttaaagtcat   3300

ttttccagca atgtttaaat tactttctca ttcttttagt gtattcaaca ttgtctgcct   3360

cttcctgcag ttgatgtaat tgctttgttt gcaatagcac aagctgcatt attccagtca   3420

ggactgtgat aacttgctgc cagccccact caactttcag ttggctctgt gtcagttttc   3480

cattcagtgt taactacttg ttactgccat gctgcttgcc ctcccttgaa gtgtctataa   3540

gctcatcaca gcctagagtt aagtaaagtc aattcacaga agcacaattt tgccctttgc   3600

gagacattgt tgcctctatc tagtcctaca agtagggttt tgcatactgt gtttgcccct   3660

agggttgtca gtgcatcaga aatacttcta aatagtggta aaaatgcaca tggttaatgc   3720

acatgttact tttaaatcat taggatatcc ctcacctgtt cctgatgaat aaaaagtgtg   3780

ttaaagacca aaattcttgg cataataatc agctacatac aaatcacata tagtttaatc   3840

ttttttaatg aaaaaaaatc atgtttaaaa tggcaaaagc ccatcttata cacttttata   3900

tagctgcaaa aaatttatat ctgtacagat ctaacactac gacactcagt attcatttta   3960

ttgaagcatg caagtaaagc actttttcta atttatatag aggtatctaa ttaacacagc   4020

acattgtact aatgactagg agtagcagct ttttcttctc tccctctatg aattcttata   4080

atgtcccttt ttctgtaagt ttttgagagg caattggcaa tttaggaggc agcagggtct   4140

gttttggtca aatcttgaat ttcgttgttg cactctagtg actgatcttt gggaatgtct   4200

tgtctttgca tggggctcat agagatgtgt gcagacttgc ttattgtggt tagtgtgtat   4260

caggaacaca cacacaggtg ttctgaccag ctcaggcttg ccacagtgag caactctgtg   4320

gctagcaaaa gagaagttta tttgtgccca gccattggtc accttgggtg atgcaccaga   4380

tagcaggcag atgttggttc attggccttc gtcctctttc ctcctaaaat aatattggct   4440

ttaccatctt aactcagctg tgggtttttt gtgggttctt gtttgttttt tggcatgaat   4500

tgtcatcttt ggtgtttttt taacccccag cccctcaaaa aaataaggcc tccaggtatc   4560

aagatctcat attaggattt tctgtcctta attttttgag caaaatctgg aaaatgtgaa   4620

agcatattta gattttatat actatctgaa atgtgatttg ttaagattct taaatttggg   4680

cctcttagaa taattttgaa tgagatctac cgactcactt gtgagaatat ttttcacaga   4740

ttatctttgg gccttttcat tagaaagctg tttgtttgtc cccctgttgg tacatttggt   4800

tacctcattt tgccgtttca gattgtgaaa gctcacaggg gtgttttttg gaatcatttg   4860

ctgagtcatt ttctcaaatc atattccatt gtatcagtta acatatagtt ttaaatgtat   4920

gtattataaa tatctgtaac caaatcattt gaaggcttga taaattttta acaaagtttg   4980

tacatttttt atgaaagtta ctagtaatgc tttactaagt agtgcaatga atttttattt   5040

ttaatccctg tgcccaattt tggagttgag agggttgttg gtaataaatg tatgatgtac   5100

acttaaaaaa aaaaaaaa                                                 5118


<210>  2354
<211>  432
<212>  PRT
<213>  Homosapiens

<400>  2354

Met Arg Pro Trp Glu Met Thr Ser Asn Arg Gln Pro Pro Ser Val Arg 
1               5                   10                  15      


Pro Ser Gln His His Phe Ser Gly Glu Arg Cys Asn Thr Pro Ala Arg 
            20                  25                  30          


Asn Arg Arg Ser Pro Pro Val Arg Arg Gln Arg Gly Arg Arg Asp Arg 
        35                  40                  45              


Leu Ser Arg His Asn Ser Ile Ser Gln Asp Glu Asn Tyr His His Leu 
    50                  55                  60                  


Pro Tyr Ala Gln Gln Gln Ala Ile Glu Glu Pro Arg Ala Phe His Pro 
65                  70                  75                  80  


Pro Asn Val Ser Pro Arg Leu Leu His Pro Ala Ala His Pro Pro Gln 
                85                  90                  95      


Gln Asn Ala Val Met Val Asp Ile His Asp Gln Leu His Gln Gly Thr 
            100                 105                 110         


Val Pro Val Ser Tyr Thr Val Thr Thr Val Ala Pro His Gly Ile Pro 
        115                 120                 125             


Leu Cys Thr Gly Gln His Ile Pro Ala Cys Ser Thr Gln Gln Val Pro 
    130                 135                 140                 


Gly Cys Ser Val Val Phe Ser Gly Gln His Leu Pro Val Cys Ser Val 
145                 150                 155                 160 


Pro Pro Pro Met Leu Gln Ala Cys Ser Val Gln His Leu Pro Val Pro 
                165                 170                 175     


Tyr Ala Ala Phe Pro Pro Leu Ile Ser Ser Asp Pro Phe Leu Ile His 
            180                 185                 190         


Pro Pro His Leu Ser Pro His His Pro Pro His Leu Pro Pro Pro Gly 
        195                 200                 205             


Gln Phe Val Pro Phe Gln Thr Gln Gln Ser Arg Ser Pro Leu Gln Arg 
    210                 215                 220                 


Ile Glu Asn Glu Val Glu Leu Leu Gly Glu His Leu Pro Val Gly Gly 
225                 230                 235                 240 


Phe Thr Tyr Pro Pro Ser Ala His Pro Pro Thr Leu Pro Pro Ser Ala 
                245                 250                 255     


Pro Leu Gln Phe Leu Thr His Asp Pro Leu His Gln Glu Val Ser Phe 
            260                 265                 270         


Gly Val Pro Tyr Pro Pro Phe Met Pro Arg Arg Leu Thr Gly Arg Ser 
        275                 280                 285             


Arg Tyr Arg Ser Gln Gln Pro Ile Pro Pro Pro Pro Tyr His Pro Ser 
    290                 295                 300                 


Leu Leu Pro Tyr Val Leu Ser Met Leu Pro Val Pro Pro Ala Val Gly 
305                 310                 315                 320 


Pro Thr Phe Ser Phe Glu Leu Asp Val Glu Asp Gly Glu Val Glu Asn 
                325                 330                 335     


Tyr Glu Ala Leu Leu Asn Leu Ala Glu Arg Leu Gly Glu Ala Lys Pro 
            340                 345                 350         


Arg Gly Leu Thr Lys Ala Asp Ile Glu Gln Leu Pro Ser Tyr Arg Phe 
        355                 360                 365             


Asn Pro Asn Asn His Gln Ser Glu Gln Thr Leu Cys Val Val Cys Met 
    370                 375                 380                 


Cys Asp Phe Glu Ser Arg Gln Leu Leu Arg Val Leu Pro Cys Asn His 
385                 390                 395                 400 


Glu Phe His Ala Lys Cys Val Asp Lys Trp Leu Lys Ala Asn Arg Thr 
                405                 410                 415     


Cys Pro Ile Cys Arg Ala Asp Ala Ser Glu Val His Arg Asp Ser Glu 
            420                 425                 430         


<210>  2355
<211>  2501
<212>  DNA
<213>  Homosapiens

<400>  2355
cgaaaagatt cttaggaacg ccgtaccagc cgcgtctctc aggacagcag gcccctgtcc     60

ttctgtcggg cgccgctcag ccgtgccctc cgcccctcag gttctttttc taattccaaa    120

taaacttgca agaggactat gaaagattat gatgaacttc tcaaatatta tgaattacat    180

gaaactattg ggacaggtgg ctttgcaaag gtcaaacttg cctgccatat ccttactgga    240

gagatggtag ctataaaaat catggataaa aacacactag ggagtgattt gccccggatc    300

aaaacggaga ttgaggcctt gaagaacctg agacatcagc atatatgtca actctaccat    360

gtgctagaga cagccaacaa aatattcatg gttcttgagt actgccctgg aggagagctg    420

tttgactata taatttccca ggatcgcctg tcagaagagg agacccgggt tgtcttccgt    480

cagatagtat ctgctgttgc ttatgtgcac agccagggct atgctcacag ggacctcaag    540

ccagaaaatt tgctgtttga tgaatatcat aaattaaagc tgattgactt tggtctctgt    600

gcaaaaccca agggtaacaa ggattaccat ctacagacat gctgtgggag tctggcttat    660

gcagcacctg agttaataca aggcaaatca tatcttggat cagaggcaga tgtttggagc    720

atgggcatac tgttatatgt tcttatgtgt ggatttctac catttgatga tgataatgta    780

atggctttat acaagaagat tatgagagga aaatatgatg ttcccaagtg gctctctccc    840

agtagcattc tgcttcttca acaaatgctg caggtggacc caaagaaacg gatttctatg    900

aaaaatctat tgaaccatcc ctggatcatg caagattaca actatcctgt tgagtggcaa    960

agcaagaatc cttttattca cctcgatgat gattgcgtaa cagaactttc tgtacatcac   1020

agaaacaaca ggcaaacaat ggaggattta atttcactgt ggcagtatga tcacctcacg   1080

gctacctatc ttctgcttct agccaagaag gctcggggaa aaccagttcg tttaaggctt   1140

tcttctttct cctgtggaca agccagtgct accccattca cagacatcaa gtcaaataat   1200

tggagtctgg aagatgtgac cgcaagtgat aaaaattatg tggcgggatt aatagactat   1260

gattggtgtg aagatgattt atcaacaggt gctgctactc cccgaacatc acagtttacc   1320

aagtactgga cagaatcaaa tggggtggaa tctaaatcat taactccagc cttatgcaga   1380

acacctgcaa ataaattaaa gaacaaagaa aatgtatata ctcctaagtc tgctgtaaag   1440

aatgaagagt actttatgtt tcctgagcca aagactccag ttaataagaa ccagcataag   1500

agagaaatac tcactacgcc aaatcgttac actacaccct caaaagctag aaaccagtgc   1560

ctgaaagaaa ctccaattaa aataccagta aattcaacag gaacagacaa gttaatgaca   1620

ggtgtcatta gccctgagag gcggtgccgc tcagtggaat tggatctcaa ccaagcacat   1680

atggaggaga ctccaaaaag aaagggagcc aaagtgtttg ggagccttga aagggggttg   1740

gataaggtta tcactgtgct caccaggagc aaaaggaagg gttctgccag agacgggccc   1800

agaagactaa agcttcacta taatgtgact acaactagat tagtgaatcc agatcaactg   1860

ttgaatgaaa taatgtctat tcttccaaag aagcatgttg actttgtaca aaagggttat   1920

acactgaagt gtcaaacaca gtcagatttt gggaaagtga caatgcaatt tgaattagaa   1980

gtgtgccagc ttcaaaaacc cgatgtggtg ggtatcagga ggcagcggct taagggcgat   2040

gcctgggttt acaaaagatt agtggaagac atcctatcta gctgcaaggt ataattgatg   2100

gattcttcca tcctgccgga tgagtgtggg tgtgatacag cctacataaa gactgttatg   2160

atcgctttga ttttaaagtt cattggaact accaacttgt ttctaaagag ctatcttaag   2220

accaatatct ctttgttttt aaacaaaaga tattattttg tgtatgaatc taaatcaagc   2280

ccatctgtca ttatgttact gtctttttta atcatgtggt tttgtatatt aataattgtt   2340

gactttctta gattcacttc catatgtgaa tgtaagctct taactatgtc tctttgtaat   2400

gtgtaatttc tttctgaaat aaaaccattt gtgaatataa aaaaaaaaaa aaaaaaaaaa   2460

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       2501


<210>  2356
<211>  651
<212>  PRT
<213>  Homosapiens

<400>  2356

Met Lys Asp Tyr Asp Glu Leu Leu Lys Tyr Tyr Glu Leu His Glu Thr 
1               5                   10                  15      


Ile Gly Thr Gly Gly Phe Ala Lys Val Lys Leu Ala Cys His Ile Leu 
            20                  25                  30          


Thr Gly Glu Met Val Ala Ile Lys Ile Met Asp Lys Asn Thr Leu Gly 
        35                  40                  45              


Ser Asp Leu Pro Arg Ile Lys Thr Glu Ile Glu Ala Leu Lys Asn Leu 
    50                  55                  60                  


Arg His Gln His Ile Cys Gln Leu Tyr His Val Leu Glu Thr Ala Asn 
65                  70                  75                  80  


Lys Ile Phe Met Val Leu Glu Tyr Cys Pro Gly Gly Glu Leu Phe Asp 
                85                  90                  95      


Tyr Ile Ile Ser Gln Asp Arg Leu Ser Glu Glu Glu Thr Arg Val Val 
            100                 105                 110         


Phe Arg Gln Ile Val Ser Ala Val Ala Tyr Val His Ser Gln Gly Tyr 
        115                 120                 125             


Ala His Arg Asp Leu Lys Pro Glu Asn Leu Leu Phe Asp Glu Tyr His 
    130                 135                 140                 


Lys Leu Lys Leu Ile Asp Phe Gly Leu Cys Ala Lys Pro Lys Gly Asn 
145                 150                 155                 160 


Lys Asp Tyr His Leu Gln Thr Cys Cys Gly Ser Leu Ala Tyr Ala Ala 
                165                 170                 175     


Pro Glu Leu Ile Gln Gly Lys Ser Tyr Leu Gly Ser Glu Ala Asp Val 
            180                 185                 190         


Trp Ser Met Gly Ile Leu Leu Tyr Val Leu Met Cys Gly Phe Leu Pro 
        195                 200                 205             


Phe Asp Asp Asp Asn Val Met Ala Leu Tyr Lys Lys Ile Met Arg Gly 
    210                 215                 220                 


Lys Tyr Asp Val Pro Lys Trp Leu Ser Pro Ser Ser Ile Leu Leu Leu 
225                 230                 235                 240 


Gln Gln Met Leu Gln Val Asp Pro Lys Lys Arg Ile Ser Met Lys Asn 
                245                 250                 255     


Leu Leu Asn His Pro Trp Ile Met Gln Asp Tyr Asn Tyr Pro Val Glu 
            260                 265                 270         


Trp Gln Ser Lys Asn Pro Phe Ile His Leu Asp Asp Asp Cys Val Thr 
        275                 280                 285             


Glu Leu Ser Val His His Arg Asn Asn Arg Gln Thr Met Glu Asp Leu 
    290                 295                 300                 


Ile Ser Leu Trp Gln Tyr Asp His Leu Thr Ala Thr Tyr Leu Leu Leu 
305                 310                 315                 320 


Leu Ala Lys Lys Ala Arg Gly Lys Pro Val Arg Leu Arg Leu Ser Ser 
                325                 330                 335     


Phe Ser Cys Gly Gln Ala Ser Ala Thr Pro Phe Thr Asp Ile Lys Ser 
            340                 345                 350         


Asn Asn Trp Ser Leu Glu Asp Val Thr Ala Ser Asp Lys Asn Tyr Val 
        355                 360                 365             


Ala Gly Leu Ile Asp Tyr Asp Trp Cys Glu Asp Asp Leu Ser Thr Gly 
    370                 375                 380                 


Ala Ala Thr Pro Arg Thr Ser Gln Phe Thr Lys Tyr Trp Thr Glu Ser 
385                 390                 395                 400 


Asn Gly Val Glu Ser Lys Ser Leu Thr Pro Ala Leu Cys Arg Thr Pro 
                405                 410                 415     


Ala Asn Lys Leu Lys Asn Lys Glu Asn Val Tyr Thr Pro Lys Ser Ala 
            420                 425                 430         


Val Lys Asn Glu Glu Tyr Phe Met Phe Pro Glu Pro Lys Thr Pro Val 
        435                 440                 445             


Asn Lys Asn Gln His Lys Arg Glu Ile Leu Thr Thr Pro Asn Arg Tyr 
    450                 455                 460                 


Thr Thr Pro Ser Lys Ala Arg Asn Gln Cys Leu Lys Glu Thr Pro Ile 
465                 470                 475                 480 


Lys Ile Pro Val Asn Ser Thr Gly Thr Asp Lys Leu Met Thr Gly Val 
                485                 490                 495     


Ile Ser Pro Glu Arg Arg Cys Arg Ser Val Glu Leu Asp Leu Asn Gln 
            500                 505                 510         


Ala His Met Glu Glu Thr Pro Lys Arg Lys Gly Ala Lys Val Phe Gly 
        515                 520                 525             


Ser Leu Glu Arg Gly Leu Asp Lys Val Ile Thr Val Leu Thr Arg Ser 
    530                 535                 540                 


Lys Arg Lys Gly Ser Ala Arg Asp Gly Pro Arg Arg Leu Lys Leu His 
545                 550                 555                 560 


Tyr Asn Val Thr Thr Thr Arg Leu Val Asn Pro Asp Gln Leu Leu Asn 
                565                 570                 575     


Glu Ile Met Ser Ile Leu Pro Lys Lys His Val Asp Phe Val Gln Lys 
            580                 585                 590         


Gly Tyr Thr Leu Lys Cys Gln Thr Gln Ser Asp Phe Gly Lys Val Thr 
        595                 600                 605             


Met Gln Phe Glu Leu Glu Val Cys Gln Leu Gln Lys Pro Asp Val Val 
    610                 615                 620                 


Gly Ile Arg Arg Gln Arg Leu Lys Gly Asp Ala Trp Val Tyr Lys Arg 
625                 630                 635                 640 


Leu Val Glu Asp Ile Leu Ser Ser Cys Lys Val 
                645                 650     


<210>  2357
<211>  6147
<212>  DNA
<213>  Homosapiens

<400>  2357
gcgggcgccg gcaatcgagt ggcttcctgg ccatggagag gagatctgga cccgaggacg     60

ccagggactc ctctccgtct ccctggaccg ctgtgtaggc acctgagtta acggacgcta    120

agcggggtag gggaagtaac agtgtatcat gtatgccact gattccaggg gacactcccc    180

tgctttcctc caacctcaga atggaaatag tcgtcaccca tctggctatg ttccagggaa    240

ggttgtccca ttgcgtcccc ctcctcctcc aaagagtcaa gcttcagcca aatttacctc    300

catcagacga gaagaccggg caaccttcgc attctcacct gaagaacagc aagcccagag    360

agaaagtcaa aagcaaaaga gacacaaaaa tactttcatt tgttttgcta ttactagttt    420

ctcatttttt attgcacttg caatcatttt aggaatatcc tcaaaatatg ctccagatga    480

aaattgccca gatcaaaatc ctcgtctcag gaattgggat ccaggacaag attctgcaaa    540

gcaagttgtt atcaaggagg gagatatgct ccgtctgacc tcagacgcca ccgtgcattc    600

tatagtcatt caggatggag gactgcttgt atttggggac aataaagatg gatccagaaa    660

tattactttg aggactcatt acatcctgat ccaggatggt ggggcgcttc atattggagc    720

agaaaaatgc cgctataaat ccaaagcgac aattaccttg tatggcaagt cagatgaagg    780

tgaaagtatg ccaacatttg gcaaaaagtt tattggtgtg gaagctggcg ggacactgga    840

gttacatggg gcacggaagg catcgtggac gttgttggca aggaccctga attcctcagg    900

cttgcccttt gggtcctata cctttgaaaa ggacttttcc cggggcctca atgtgagggt    960

cattgaccaa gacacggcca aaattttgga aagtgagaga tttgataccc atgaataccg   1020

caatgagagc aggcggcttc aggagtttct gagattccag gatccaggtc ggattgttgc   1080

catagctgtc ggggattcag ccgctaaaag tctcttacaa ggaaccatcc agatgatcca   1140

ggaacggttg ggaagtgaac tgatccaagg actgggctac aggcaagctt gggctttagt   1200

tggtgtcatt gatggtggaa gcacttcttg caatgaatcc gtgagaaact atgaaaatca   1260

tagcagtggc gggaaggctc ttgcccaaag agaattttat actgtggatg gccagaagtt   1320

ctctgtgaca gcttatagtg aatggattga aggcgtttct ctttcaggat tccgggtaga   1380

ggttgtagat ggagtgaagc taaatttgct agatgatgtt agtagttgga aacctggaga   1440

ccagattgtg gtcgcaagca cagactattc catgtaccaa gcagaggagt tcactcttct   1500

tccctgttct gaatgcagcc attttcaggt caaagtcaaa gaaacccctc agttcctgca   1560

catgggtgag atcatagacg gtgtagacat gagagctgag gttggaattc ttacccggaa   1620

tattgtgatc caaggagaag tggaggactc atgctacgca gaaaatcagt gccaattttt   1680

tgattatgat acctttgggg gacacattat gataatgaaa aattttactt cagtccatct   1740

ttcttatgtg gaattgaaac acatgggtca gcagcagatg gggcgatacc ctgttcattt   1800

tcacctgtgt ggtgacgtgg attataaagg aggatacaga catgcaacat ttgtggacgg   1860

cctgtctatt catcacagct tctcaaggtg catcactgtg catgggacaa atggcttgct   1920

aataaaagac accattgggt ttgacacact aggtcattgt ttctttttgg aagatggtat   1980

tgaacagagg aatactttgt tccacaatct gggactcctc accaagccgg gtactctcct   2040

gcccaccgat aggaacaact ccatgtgtac caccatgcga gataaagtgt ttggaaatta   2100

cattcctgtg cctgctactg actgtatggc tgtttcaact ttctggattg ctcatcccaa   2160

caataatctg attaataatg cagctgcagg ctcacaggat gctggaatat ggtatttatt   2220

ccacaaggaa ccaactgggg aatccagtgg attgcagctc ttggcaaaac cagaactcac   2280

tccattgggt atattttata acaacagggt ccattcaaat tttaaggctg gcttatttat   2340

tgacaaaggt gtcaaaacaa ccaactctag tgctgctgac ccaagggaat acctctgttt   2400

ggacaatagt gcaagatttc gacctcatca ggatgcaaac cccgaaaaac cacgtgttgc   2460

tgctctaatt gacaggctca ttgcttttaa aaataatgat aatggagctt gggtcagagg   2520

aggagatatt atcgttcaaa attcagcatt tgcagataat ggaataggac tgacctttgc   2580

cagtgatgga agcttcccaa gtgatgaagg ttccagccaa gaggtatctg aatctctctt   2640

tgttggggag agcaggaatt acggctttca gggtggtcag aacaagtatg taggcactgg   2700

aggaatagac cagaagcctc gaacattacc caggaacagg acgttcccaa ttagaggctt   2760

tcagatttat gatgggccca ttcatctcac aaggagcact ttcaaaaaat atgtgccaac   2820

tccagatagg tacagcagtg caattggctt cctcatgaag aattcctggc agataacccc   2880

caggaataat atctccctcg tgaagtttgg tccacatgtc tctctgaatg tcttttttgg   2940

aaagcctggt ccctggtttg aagattgtga gatggatggt gataagaact ccatattcca   3000

tgacattgat ggctctgtga caggatacaa ggatgcttat gtgggaagaa tggacaacta   3060

cctgatccgc catccaagct gtgtaaatgt gtctaagtgg aatgcagtga tctgcagtgg   3120

gacctatgca caggtctatg tacagacatg gagcactcag aatctttcta tgaccattac   3180

acgagatgag tatccgtcca accctatggt gctccgaggt attaatcaga aggctgcctt   3240

tccacagtac cagcctgtcg tcatgctgga gaagggttat accatccact ggaatgggcc   3300

ggcaccacgg actacatttc tatacctcgt caacttcaac aagaatgact ggattcgagt   3360

tggcctttgc tatccatcaa acacaagttt tcaagttacc tttggctatt tgcagcggca   3420

gaatggctca ttatccaaaa tcgaagaata tgagcctgtg cattcactgg aagaactgca   3480

aagaaagcaa tccgagagga aattctattt tgactccagc acggggttac tgtttttgta   3540

tctcaaagcc aaaagccaca ggcatggcca cagttactgt tcatctcagg gatgtgaaag   3600

agtcaagatc caagcagcca cagactcaaa ggacatcagt aactgcatgg ccaaagcata   3660

cccacagtac tacagaaagc cgtcagtggt caagcggatg ccggccatgc tcactggact   3720

ctgtcaaggc tgtggcactc ggcaggtggt gtttactagt gatcctcata aaagttacct   3780

ccctgtgcaa ttccagtcac ctgataaagc agaaacccag cgtggagacc cgtctgttat   3840

ttctgtcaat ggcactgact ttaccttccg aagtgcaggc gtcctcctcc ttgttgtgga   3900

tccgtgcagc gttccattcc gcttgacgga aaaaacggtt tttcctcttg ctgatgtcag   3960

tcgcattgaa gagtatttaa aaacaggcat ccctccaagg tccattgttc tgttgagcac   4020

aagaggagaa ataaagcagt taaacatttc acacttacta gtacctctgg gattagccaa   4080

accagctcat ctttatgaca aagggagtac catatttttg ggattcagtg gaaactttaa   4140

accatcatgg actaagctat ttaccagtcc tgctggacag ggccttgggg tgcttgaaca   4200

attcatacct ttgcagctgg acgaatatgg ttgtcccaga gccaccactg tccgcagaag   4260

agacctggaa ctgctaaagc aagcttcaaa agcacattag agactaactg taacttaagt   4320

gctgggggaa aaaaaatgtg aactaactta tttaatttat ggcattttaa aatgacactg   4380

ttaacccaac ggaaccattt tccagtttga tacagaatgg ggagaaaaga aagcgtttga   4440

aattattgct tggataccag cttcatgcac cttctagttg tacaaaatgt taaagacgtt   4500

gtttgtattt gtaaggctgg tgtattcaga gagcagatct cttattcctc actttccacc   4560

cccgtatttt gtaatgacca tgagcaatgt ttttactttt tgtataatgg ggtggggtgg   4620

agtgggggct tctgagagtc agcctgaggt ctttagagga ccagctattg tagcaccttg   4680

gatacttgaa gtttaatgct cagttgggtc gggtggcagt tgacttggtg gctggcatgt   4740

tcagcagtgc ctggggccct gtttctgggc agcctttgag gattttctat gatattgaat   4800

gacagtttta agtggcaact caggcccagc tcatgccctt ttttgcctgg acatgtgcta   4860

tttttattca cttatatatc aattacttgt aagggttaaa ctttcaaaca ggaagtatat   4920

tgggacaaaa gggctcttgg ggattagata tccctttaat ctgtgaccat ggggcaaaaa   4980

attttcctgc agcaaaagtc tgaggctgtt gggaccattt ttgcagcttt aatccttagc   5040

ctcttttgac tgtatatttg tgtttaaaat gcagagctca actgaatatt tccttttttg   5100

ttttgttttg ttttgtttta agaagtaggt tgttttcctg aaccgtaaac ttgtatcatt   5160

ttaacttgca caaaggaagt ctgttcttgg tattgctctt gcacttgggt tttttgttat   5220

tgttttgtgt ggatttttta aagcttttct gttcaccctc ctgccaggaa aatcccagaa   5280

agcttaatga taccccaaaa tgattacacc cagggaggaa aaaaaggagc gctttctagg   5340

gtcagaatcg tggagagaat actcagaaca tgaacctctt taaagccttg caggaatgag   5400

tcactcttac ttaatgaaat gttaaagcca attaaaaagc atgctgtgat gcccagcttc   5460

cctttccaca gggtgcatgc gtctcctgct ggtgaatcac atgcggcaag aggcaactgg   5520

ctccacagcc tgggatgctg ccgtaccaag aggaaagaag cagcaaaatg cctttacgtt   5580

gttctaaacc cccgacgcat aaagtgtaga ggagggatgg ccaagggtgg gtggtagaaa   5640

gtgtgttcag gctgacactg gcaatgagta cagataattt cactttcctc ttccaggggc   5700

aaaggctgat ggcctctacc tttgtatcca ggagaaactg cagagcagcc ctgtgacttt   5760

acaaaatatg ctacctcaaa gtgctaccga taaacctttc taattgtaag tgcccttact   5820

aagggcacat gtcttaatca aagttagttt tttgttttct ggtttgtttt tttttttttt   5880

gtatattgat gaatgagatc ttacctatta aatatattat tggaaaaaaa aaaaaaaaaa   5940

aaattaaagt ttgagtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttttatg   6000

acttaaatat ctttacgtgt gttttttaga gcttggttct ttaaagattt ggagaagata   6060

tgtaaattac caaggcactt ggtttttctg ttttatatac taataatcag ggcctaagtt   6120

aaataaaaat atgtgtgcat gtatttt                                       6147


<210>  2358
<211>  1383
<212>  PRT
<213>  Homosapiens

<400>  2358

Met Tyr Ala Thr Asp Ser Arg Gly His Ser Pro Ala Phe Leu Gln Pro 
1               5                   10                  15      


Gln Asn Gly Asn Ser Arg His Pro Ser Gly Tyr Val Pro Gly Lys Val 
            20                  25                  30          


Val Pro Leu Arg Pro Pro Pro Pro Pro Lys Ser Gln Ala Ser Ala Lys 
        35                  40                  45              


Phe Thr Ser Ile Arg Arg Glu Asp Arg Ala Thr Phe Ala Phe Ser Pro 
    50                  55                  60                  


Glu Glu Gln Gln Ala Gln Arg Glu Ser Gln Lys Gln Lys Arg His Lys 
65                  70                  75                  80  


Asn Thr Phe Ile Cys Phe Ala Ile Thr Ser Phe Ser Phe Phe Ile Ala 
                85                  90                  95      


Leu Ala Ile Ile Leu Gly Ile Ser Ser Lys Tyr Ala Pro Asp Glu Asn 
            100                 105                 110         


Cys Pro Asp Gln Asn Pro Arg Leu Arg Asn Trp Asp Pro Gly Gln Asp 
        115                 120                 125             


Ser Ala Lys Gln Val Val Ile Lys Glu Gly Asp Met Leu Arg Leu Thr 
    130                 135                 140                 


Ser Asp Ala Thr Val His Ser Ile Val Ile Gln Asp Gly Gly Leu Leu 
145                 150                 155                 160 


Val Phe Gly Asp Asn Lys Asp Gly Ser Arg Asn Ile Thr Leu Arg Thr 
                165                 170                 175     


His Tyr Ile Leu Ile Gln Asp Gly Gly Ala Leu His Ile Gly Ala Glu 
            180                 185                 190         


Lys Cys Arg Tyr Lys Ser Lys Ala Thr Ile Thr Leu Tyr Gly Lys Ser 
        195                 200                 205             


Asp Glu Gly Glu Ser Met Pro Thr Phe Gly Lys Lys Phe Ile Gly Val 
    210                 215                 220                 


Glu Ala Gly Gly Thr Leu Glu Leu His Gly Ala Arg Lys Ala Ser Trp 
225                 230                 235                 240 


Thr Leu Leu Ala Arg Thr Leu Asn Ser Ser Gly Leu Pro Phe Gly Ser 
                245                 250                 255     


Tyr Thr Phe Glu Lys Asp Phe Ser Arg Gly Leu Asn Val Arg Val Ile 
            260                 265                 270         


Asp Gln Asp Thr Ala Lys Ile Leu Glu Ser Glu Arg Phe Asp Thr His 
        275                 280                 285             


Glu Tyr Arg Asn Glu Ser Arg Arg Leu Gln Glu Phe Leu Arg Phe Gln 
    290                 295                 300                 


Asp Pro Gly Arg Ile Val Ala Ile Ala Val Gly Asp Ser Ala Ala Lys 
305                 310                 315                 320 


Ser Leu Leu Gln Gly Thr Ile Gln Met Ile Gln Glu Arg Leu Gly Ser 
                325                 330                 335     


Glu Leu Ile Gln Gly Leu Gly Tyr Arg Gln Ala Trp Ala Leu Val Gly 
            340                 345                 350         


Val Ile Asp Gly Gly Ser Thr Ser Cys Asn Glu Ser Val Arg Asn Tyr 
        355                 360                 365             


Glu Asn His Ser Ser Gly Gly Lys Ala Leu Ala Gln Arg Glu Phe Tyr 
    370                 375                 380                 


Thr Val Asp Gly Gln Lys Phe Ser Val Thr Ala Tyr Ser Glu Trp Ile 
385                 390                 395                 400 


Glu Gly Val Ser Leu Ser Gly Phe Arg Val Glu Val Val Asp Gly Val 
                405                 410                 415     


Lys Leu Asn Leu Leu Asp Asp Val Ser Ser Trp Lys Pro Gly Asp Gln 
            420                 425                 430         


Ile Val Val Ala Ser Thr Asp Tyr Ser Met Tyr Gln Ala Glu Glu Phe 
        435                 440                 445             


Thr Leu Leu Pro Cys Ser Glu Cys Ser His Phe Gln Val Lys Val Lys 
    450                 455                 460                 


Glu Thr Pro Gln Phe Leu His Met Gly Glu Ile Ile Asp Gly Val Asp 
465                 470                 475                 480 


Met Arg Ala Glu Val Gly Ile Leu Thr Arg Asn Ile Val Ile Gln Gly 
                485                 490                 495     


Glu Val Glu Asp Ser Cys Tyr Ala Glu Asn Gln Cys Gln Phe Phe Asp 
            500                 505                 510         


Tyr Asp Thr Phe Gly Gly His Ile Met Ile Met Lys Asn Phe Thr Ser 
        515                 520                 525             


Val His Leu Ser Tyr Val Glu Leu Lys His Met Gly Gln Gln Gln Met 
    530                 535                 540                 


Gly Arg Tyr Pro Val His Phe His Leu Cys Gly Asp Val Asp Tyr Lys 
545                 550                 555                 560 


Gly Gly Tyr Arg His Ala Thr Phe Val Asp Gly Leu Ser Ile His His 
                565                 570                 575     


Ser Phe Ser Arg Cys Ile Thr Val His Gly Thr Asn Gly Leu Leu Ile 
            580                 585                 590         


Lys Asp Thr Ile Gly Phe Asp Thr Leu Gly His Cys Phe Phe Leu Glu 
        595                 600                 605             


Asp Gly Ile Glu Gln Arg Asn Thr Leu Phe His Asn Leu Gly Leu Leu 
    610                 615                 620                 


Thr Lys Pro Gly Thr Leu Leu Pro Thr Asp Arg Asn Asn Ser Met Cys 
625                 630                 635                 640 


Thr Thr Met Arg Asp Lys Val Phe Gly Asn Tyr Ile Pro Val Pro Ala 
                645                 650                 655     


Thr Asp Cys Met Ala Val Ser Thr Phe Trp Ile Ala His Pro Asn Asn 
            660                 665                 670         


Asn Leu Ile Asn Asn Ala Ala Ala Gly Ser Gln Asp Ala Gly Ile Trp 
        675                 680                 685             


Tyr Leu Phe His Lys Glu Pro Thr Gly Glu Ser Ser Gly Leu Gln Leu 
    690                 695                 700                 


Leu Ala Lys Pro Glu Leu Thr Pro Leu Gly Ile Phe Tyr Asn Asn Arg 
705                 710                 715                 720 


Val His Ser Asn Phe Lys Ala Gly Leu Phe Ile Asp Lys Gly Val Lys 
                725                 730                 735     


Thr Thr Asn Ser Ser Ala Ala Asp Pro Arg Glu Tyr Leu Cys Leu Asp 
            740                 745                 750         


Asn Ser Ala Arg Phe Arg Pro His Gln Asp Ala Asn Pro Glu Lys Pro 
        755                 760                 765             


Arg Val Ala Ala Leu Ile Asp Arg Leu Ile Ala Phe Lys Asn Asn Asp 
    770                 775                 780                 


Asn Gly Ala Trp Val Arg Gly Gly Asp Ile Ile Val Gln Asn Ser Ala 
785                 790                 795                 800 


Phe Ala Asp Asn Gly Ile Gly Leu Thr Phe Ala Ser Asp Gly Ser Phe 
                805                 810                 815     


Pro Ser Asp Glu Gly Ser Ser Gln Glu Val Ser Glu Ser Leu Phe Val 
            820                 825                 830         


Gly Glu Ser Arg Asn Tyr Gly Phe Gln Gly Gly Gln Asn Lys Tyr Val 
        835                 840                 845             


Gly Thr Gly Gly Ile Asp Gln Lys Pro Arg Thr Leu Pro Arg Asn Arg 
    850                 855                 860                 


Thr Phe Pro Ile Arg Gly Phe Gln Ile Tyr Asp Gly Pro Ile His Leu 
865                 870                 875                 880 


Thr Arg Ser Thr Phe Lys Lys Tyr Val Pro Thr Pro Asp Arg Tyr Ser 
                885                 890                 895     


Ser Ala Ile Gly Phe Leu Met Lys Asn Ser Trp Gln Ile Thr Pro Arg 
            900                 905                 910         


Asn Asn Ile Ser Leu Val Lys Phe Gly Pro His Val Ser Leu Asn Val 
        915                 920                 925             


Phe Phe Gly Lys Pro Gly Pro Trp Phe Glu Asp Cys Glu Met Asp Gly 
    930                 935                 940                 


Asp Lys Asn Ser Ile Phe His Asp Ile Asp Gly Ser Val Thr Gly Tyr 
945                 950                 955                 960 


Lys Asp Ala Tyr Val Gly Arg Met Asp Asn Tyr Leu Ile Arg His Pro 
                965                 970                 975     


Ser Cys Val Asn Val Ser Lys Trp Asn Ala Val Ile Cys Ser Gly Thr 
            980                 985                 990         


Tyr Ala Gln Val Tyr Val Gln Thr  Trp Ser Thr Gln Asn  Leu Ser Met 
        995                 1000                 1005             


Thr Ile  Thr Arg Asp Glu Tyr  Pro Ser Asn Pro Met  Val Leu Arg 
    1010                 1015                 1020             


Gly Ile  Asn Gln Lys Ala Ala  Phe Pro Gln Tyr Gln  Pro Val Val 
    1025                 1030                 1035             


Met Leu  Glu Lys Gly Tyr Thr  Ile His Trp Asn Gly  Pro Ala Pro 
    1040                 1045                 1050             


Arg Thr  Thr Phe Leu Tyr Leu  Val Asn Phe Asn Lys  Asn Asp Trp 
    1055                 1060                 1065             


Ile Arg  Val Gly Leu Cys Tyr  Pro Ser Asn Thr Ser  Phe Gln Val 
    1070                 1075                 1080             


Thr Phe  Gly Tyr Leu Gln Arg  Gln Asn Gly Ser Leu  Ser Lys Ile 
    1085                 1090                 1095             


Glu Glu  Tyr Glu Pro Val His  Ser Leu Glu Glu Leu  Gln Arg Lys 
    1100                 1105                 1110             


Gln Ser  Glu Arg Lys Phe Tyr  Phe Asp Ser Ser Thr  Gly Leu Leu 
    1115                 1120                 1125             


Phe Leu  Tyr Leu Lys Ala Lys  Ser His Arg His Gly  His Ser Tyr 
    1130                 1135                 1140             


Cys Ser  Ser Gln Gly Cys Glu  Arg Val Lys Ile Gln  Ala Ala Thr 
    1145                 1150                 1155             


Asp Ser  Lys Asp Ile Ser Asn  Cys Met Ala Lys Ala  Tyr Pro Gln 
    1160                 1165                 1170             


Tyr Tyr  Arg Lys Pro Ser Val  Val Lys Arg Met Pro  Ala Met Leu 
    1175                 1180                 1185             


Thr Gly  Leu Cys Gln Gly Cys  Gly Thr Arg Gln Val  Val Phe Thr 
    1190                 1195                 1200             


Ser Asp  Pro His Lys Ser Tyr  Leu Pro Val Gln Phe  Gln Ser Pro 
    1205                 1210                 1215             


Asp Lys  Ala Glu Thr Gln Arg  Gly Asp Pro Ser Val  Ile Ser Val 
    1220                 1225                 1230             


Asn Gly  Thr Asp Phe Thr Phe  Arg Ser Ala Gly Val  Leu Leu Leu 
    1235                 1240                 1245             


Val Val  Asp Pro Cys Ser Val  Pro Phe Arg Leu Thr  Glu Lys Thr 
    1250                 1255                 1260             


Val Phe  Pro Leu Ala Asp Val  Ser Arg Ile Glu Glu  Tyr Leu Lys 
    1265                 1270                 1275             


Thr Gly  Ile Pro Pro Arg Ser  Ile Val Leu Leu Ser  Thr Arg Gly 
    1280                 1285                 1290             


Glu Ile  Lys Gln Leu Asn Ile  Ser His Leu Leu Val  Pro Leu Gly 
    1295                 1300                 1305             


Leu Ala  Lys Pro Ala His Leu  Tyr Asp Lys Gly Ser  Thr Ile Phe 
    1310                 1315                 1320             


Leu Gly  Phe Ser Gly Asn Phe  Lys Pro Ser Trp Thr  Lys Leu Phe 
    1325                 1330                 1335             


Thr Ser  Pro Ala Gly Gln Gly  Leu Gly Val Leu Glu  Gln Phe Ile 
    1340                 1345                 1350             


Pro Leu  Gln Leu Asp Glu Tyr  Gly Cys Pro Arg Ala  Thr Thr Val 
    1355                 1360                 1365             


Arg Arg  Arg Asp Leu Glu Leu  Leu Lys Gln Ala Ser  Lys Ala His 
    1370                 1375                 1380             


<210>  2359
<211>  3153
<212>  DNA
<213>  Homosapiens

<400>  2359
agtaggctgg agccggggtc agctttggca ccttcctcca gtcagtggcc aactcctggc     60

tcagtgggga ttgtgctcgt cccctccgtt cccctccagt cttcctcccg ctaccggaac    120

gagcctcgcg cttggcaggc tgaggaggag caaagaaagc aggattaaag agaaggaaga    180

cctggctagg tctgggtggc gtctgcagtg ccagaaaggg aggcggtggc ggcggcggct    240

gcgaccacgg ccgcgcggga cgtgaggccc gagagcaacc gacgggcagc ggcggccgct    300

ccagcgcccc gcaccggggc cgttagtcag cagaacgcga gctcttgtgg aggagcaggg    360

ccggcgcgag gcgagactcg ggagcgtgag cggggcccct ggggcgccgc cgtccttctt    420

cgccccggcg ccgggggctg tagccctggt ccccgctcct ctgtcgggcc agtctgcagg    480

cggagagagt cggacggcgc ccggagcgcg gatctcgcct tgtggaggac agcgcgtcgg    540

ctgcggttct ctctcgaccc cttctgcccg gcgcttcggc ccgggccgct caggtgcaga    600

gcatgaataa tctttcattt agtgagctat gttgcctctt ctgctgtcca ccttgtccag    660

ggaagattgc ttcaaaatta gcgtttttgc cacctgatcc aacttacaca ctgatgtgtg    720

atgaaagcgg aagccgttgg actttacatc tgtctgaacg agcagactgg cagtattctt    780

ctagagaaaa agatgctatt gagtgtttca tgactagaac cagtaaaggc aacagaattg    840

cttgtatgtt tgtacgttgt tcacccaatg cgaaatacac tttactcttc tcacatggaa    900

atgctgttga tcttggtcaa atgagcagct tttacatagg actaggatca cggattaatt    960

gtaatatatt ctcatatgat tattctggat atggtgccag ttccgggaaa cccacagaga   1020

agaacctcta tgcagacatt gaagctgctt ggcttgctct taggacaaga tatggcattc   1080

gccctgaaaa tgtgattata tatggccaaa gtatagggac agtaccgtct gtggatcttg   1140

ctgctcgata tgagagtgct gctgttattc ttcattctcc tctgacttcg ggaatgcgag   1200

ttgcctttcc tgataccaag aagacctact gttttgatgc attcccaaac attgacaaaa   1260

tctctaagat aacctctcca gtattaataa ttcatgggac tgaagatgaa gtcattgact   1320

tttcacatgg cctcgcattg tttgaacgtt gccaaagacc tgtggagcct ctctgggttg   1380

aaggagcagg tcacaatgat gtggaacttt atggacagta tcttgaaagg ttgaaacagt   1440

ttgtgtcaca ggaactggta aatttgtaaa atattctgta aatttgctac tgggttttcc   1500

tttcttgctg aactgcactc tttggtaaat aacataaaac ctgaaggttt tgtttgcaaa   1560

tcatgtcagt tgccttcata aatgtacagg taatgatttg ttaacagact taatgaaggt   1620

tttaattacc agaactaaaa actggaaata acagtaccgt gcagtcaggc tgtgtaattt   1680

atattttttc tgtgaatttt tttttaacat caagatgagt actgtatgag attttaattc   1740

tataaaatca aatgctgtaa aagtattgcc aaatgctttt gcatactaga aacaaattta   1800

taaatatttt taaaacatct caatatatta aatcttatcc tggaatacaa ctgtaatatt   1860

ttgaaaaaag ctatgtatct aaagcaattt aagtactcat aatggaatga actgtaaaag   1920

agatttaaaa ccatgcaagt tcactagaat taacctaaac cctgttgtac agggatagag   1980

gtttaaagtt attttattgt aaaatacatt gaattttctg tatactctga ttacatacat   2040

ttatccttta aaaaagatgt aaatcttaat ttttatgcca tctattaatt taccaatgag   2100

ttaccttgta aatgagaagt catgatagca ctgaatttta actagttttg acttctaagt   2160

ttggtactgt gaggcaagta cttaaaattt tcatgctggt tacttaaaag gcatttagag   2220

atttcaagaa tgattttgta tacgatgttt taaattttga ctgatctcat agtcttcata   2280

gaattgcagt agtcttcatt gtatgaaatc ccgaaagtcc atgagttgat cttaaagacc   2340

actaacagac tggctatcag atcccttttc actttggcta tttttttcat tttttgagat   2400

ggagtcttgc tgtgtcactg aggctggagt gcagtggcgc gatcttgact cactgcaacc   2460

tctgcctccc aggatcaagt gattctcctg cctcagcctc ctgagtagct ggtattacag   2520

atgcttgcca ccacgcctgg ctaatttttg tatttttagt agagacaggg ttttgccatg   2580

ttgatcaggc tggtcttgaa ctcctgacct catgatctgc ccttggcctc ccaaagtgtc   2640

ggaattacag gcatgagcca ctgcgcctgg cccactttag ctatttttaa aaataggacc   2700

tattgttttg gattactatc tgagaatttc atggattcac tcctgggtat aggagataag   2760

aatacgttta attcataact tttatattaa ccaatatagt aaaaaaataa agctcacaca   2820

tacaaaaact aagttgcctt tccttgaatg aaccctgtct gaataaaaca atgaaaaata   2880

aaaataaaat taatggtatg tagtctaatt tgtaaatgaa tgaatatgga aataatacac   2940

actgtggata tattttaagg ccttatgtag ttttaattgt tctgctcgtt ccgtggttat   3000

gtttaagact atagtatatg actctcttca aagtatatca agtattgtga atgctttggt   3060

tcagatgtgt caaattaaca gtaaaacaac aaatatacca ctgaaaaaaa aaaaaaaaaa   3120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                3153


<210>  2360
<211>  288
<212>  PRT
<213>  Homosapiens

<400>  2360

Met Asn Asn Leu Ser Phe Ser Glu Leu Cys Cys Leu Phe Cys Cys Pro 
1               5                   10                  15      


Pro Cys Pro Gly Lys Ile Ala Ser Lys Leu Ala Phe Leu Pro Pro Asp 
            20                  25                  30          


Pro Thr Tyr Thr Leu Met Cys Asp Glu Ser Gly Ser Arg Trp Thr Leu 
        35                  40                  45              


His Leu Ser Glu Arg Ala Asp Trp Gln Tyr Ser Ser Arg Glu Lys Asp 
    50                  55                  60                  


Ala Ile Glu Cys Phe Met Thr Arg Thr Ser Lys Gly Asn Arg Ile Ala 
65                  70                  75                  80  


Cys Met Phe Val Arg Cys Ser Pro Asn Ala Lys Tyr Thr Leu Leu Phe 
                85                  90                  95      


Ser His Gly Asn Ala Val Asp Leu Gly Gln Met Ser Ser Phe Tyr Ile 
            100                 105                 110         


Gly Leu Gly Ser Arg Ile Asn Cys Asn Ile Phe Ser Tyr Asp Tyr Ser 
        115                 120                 125             


Gly Tyr Gly Ala Ser Ser Gly Lys Pro Thr Glu Lys Asn Leu Tyr Ala 
    130                 135                 140                 


Asp Ile Glu Ala Ala Trp Leu Ala Leu Arg Thr Arg Tyr Gly Ile Arg 
145                 150                 155                 160 


Pro Glu Asn Val Ile Ile Tyr Gly Gln Ser Ile Gly Thr Val Pro Ser 
                165                 170                 175     


Val Asp Leu Ala Ala Arg Tyr Glu Ser Ala Ala Val Ile Leu His Ser 
            180                 185                 190         


Pro Leu Thr Ser Gly Met Arg Val Ala Phe Pro Asp Thr Lys Lys Thr 
        195                 200                 205             


Tyr Cys Phe Asp Ala Phe Pro Asn Ile Asp Lys Ile Ser Lys Ile Thr 
    210                 215                 220                 


Ser Pro Val Leu Ile Ile His Gly Thr Glu Asp Glu Val Ile Asp Phe 
225                 230                 235                 240 


Ser His Gly Leu Ala Leu Phe Glu Arg Cys Gln Arg Pro Val Glu Pro 
                245                 250                 255     


Leu Trp Val Glu Gly Ala Gly His Asn Asp Val Glu Leu Tyr Gly Gln 
            260                 265                 270         


Tyr Leu Glu Arg Leu Lys Gln Phe Val Ser Gln Glu Leu Val Asn Leu 
        275                 280                 285             


<210>  2361
<211>  1614
<212>  DNA
<213>  Homosapiens

<400>  2361
agtaggctgg agccggggtc agctttggca ccttcctcca gtcagtggcc aactcctggc     60

tcagtgggga ttgtgctcgt cccctccgtt cccctccagt cttcctcccg ctaccggaac    120

gagcctcgcg cttggcaggc tgaggaggag caaagaaagc aggattaaag agaaggaaga    180

cctggctagg tctgggtggc gtctgcagtg ccagaaaggg aggcggtggc ggcggcggct    240

gcgaccacgg ccgcgcggga cgtgaggccc gagagcaacc gacgggcagc ggcggccgct    300

ccagcgcccc gcaccggggc cgttagtcag cagaacgcga gctcttgtgg aggagcaggg    360

ccggcgcgag gcgagactcg ggagcgtgag cggggcccct ggggcgccgc cgtccttctt    420

cgccccggcg ccgggggctg tagccctggt ccccgctcct ctgtcgggcc agtctgcagg    480

cggagagagt cggacggcgc ccggagcgcg gatctcgcct tgtggaggac agcgcgtcgg    540

ctgcggttct ctctcgaccc cttctgcccg gcgcttcggc ccgggccgct caggtgcaga    600

gcatgaataa tctttcattt agtgagctat gttgcctctt ctgctgtcca ccttgtccag    660

ggaagattgc ttcaaaatta gcgtttttgc cacctgatcc aacttacaca ctgatgtgtg    720

atgaaagcgg aagccgttgg actttacatc tgtctgaacg agcagactgg cagtattctt    780

ctagagaaaa agatgctatt gagtgtttca tgactagaac cagtaaaggc aacagaattg    840

cttgtatgtt tgtacgttgt tcacccaatg cgaaatacac tttactcttc tcacatggaa    900

atgctgttga tcttggtcaa atgagcagct tttacatagg actaggatca cggattaatt    960

gtaatatatt ctcatatgat tattctggat atggtgccag ttccgggaaa cccacagaga   1020

agaacctcta tgcagacatt gaagctgctt ggcttgctct taggacaaga tatggcattc   1080

gccctgaaaa tgtgattata tatggccaaa gtatagggac agtaccgtct gtggatcttg   1140

ctgctcgata tgagagtgct gctgttattc ttcattctcc tctgacttcg ggaatgcgag   1200

ttgcctttcc tgataccaag aagacctact gttttgatgc attcccaaac attgacaaaa   1260

tctctaagat aacctctcca gtattaataa ttcatgggac tgaagatgaa gtcattgact   1320

tttcacatgg cctcgcattg tttgaacgtt gccaaagacc tgtggagcct ctctgggttg   1380

aaggagcagg tcacaatgat gtggaacttt atggacagta tcttgaaagg ttgaaacagt   1440

ttgtgtcaca ggaactggtg cagaaacata aagaagggaa gtgattttct caaggtctac   1500

agttttcaat gacggtacta tgtattccat tatcttctct ttaccaaact taactggatt   1560

aatataccaa tgatcctttc aaattatatg acataaactt atttgctctc caaa         1614


<210>  2362
<211>  293
<212>  PRT
<213>  Homosapiens

<400>  2362

Met Asn Asn Leu Ser Phe Ser Glu Leu Cys Cys Leu Phe Cys Cys Pro 
1               5                   10                  15      


Pro Cys Pro Gly Lys Ile Ala Ser Lys Leu Ala Phe Leu Pro Pro Asp 
            20                  25                  30          


Pro Thr Tyr Thr Leu Met Cys Asp Glu Ser Gly Ser Arg Trp Thr Leu 
        35                  40                  45              


His Leu Ser Glu Arg Ala Asp Trp Gln Tyr Ser Ser Arg Glu Lys Asp 
    50                  55                  60                  


Ala Ile Glu Cys Phe Met Thr Arg Thr Ser Lys Gly Asn Arg Ile Ala 
65                  70                  75                  80  


Cys Met Phe Val Arg Cys Ser Pro Asn Ala Lys Tyr Thr Leu Leu Phe 
                85                  90                  95      


Ser His Gly Asn Ala Val Asp Leu Gly Gln Met Ser Ser Phe Tyr Ile 
            100                 105                 110         


Gly Leu Gly Ser Arg Ile Asn Cys Asn Ile Phe Ser Tyr Asp Tyr Ser 
        115                 120                 125             


Gly Tyr Gly Ala Ser Ser Gly Lys Pro Thr Glu Lys Asn Leu Tyr Ala 
    130                 135                 140                 


Asp Ile Glu Ala Ala Trp Leu Ala Leu Arg Thr Arg Tyr Gly Ile Arg 
145                 150                 155                 160 


Pro Glu Asn Val Ile Ile Tyr Gly Gln Ser Ile Gly Thr Val Pro Ser 
                165                 170                 175     


Val Asp Leu Ala Ala Arg Tyr Glu Ser Ala Ala Val Ile Leu His Ser 
            180                 185                 190         


Pro Leu Thr Ser Gly Met Arg Val Ala Phe Pro Asp Thr Lys Lys Thr 
        195                 200                 205             


Tyr Cys Phe Asp Ala Phe Pro Asn Ile Asp Lys Ile Ser Lys Ile Thr 
    210                 215                 220                 


Ser Pro Val Leu Ile Ile His Gly Thr Glu Asp Glu Val Ile Asp Phe 
225                 230                 235                 240 


Ser His Gly Leu Ala Leu Phe Glu Arg Cys Gln Arg Pro Val Glu Pro 
                245                 250                 255     


Leu Trp Val Glu Gly Ala Gly His Asn Asp Val Glu Leu Tyr Gly Gln 
            260                 265                 270         


Tyr Leu Glu Arg Leu Lys Gln Phe Val Ser Gln Glu Leu Val Gln Lys 
        275                 280                 285             


His Lys Glu Gly Lys 
    290             


<210>  2363
<211>  1328
<212>  DNA
<213>  Homosapiens

<400>  2363
cgaggctgcg ccgcgtggag tggcttggct taacagcagg gagggcagag cgatgctctt     60

tgacctccca gaagagtcac gtgggctgac ccagagccgg ggcggaaagg ctgcgttagt    120

ttcttccggg tcattgacag aagcgtcaat tcctgggagt agttcgttgg ttttctttcc    180

cctcatcctt ttgcctgctc ccggcgaggg gtggctttga tttcggcgat gagctcccag    240

aaaggcaacg tggctcgttc cagacctcag aagcaccaga atacgtttag cttcaaaaat    300

gacaagttcg ataaaagtgt gcagaccaag aaaattaatg caaaacttca tgatggagta    360

tgtcagcgct gtaaagaagt tcttgagtgg cgtgtaaaat acagcaaata caaaccatta    420

tcaaaaccta aaaagtgtgt taaatgttta caaaagacag tgaaggattc ttatcacata    480

atgtgcaggc catgtgcctg tgaacttgaa gtttgcgcaa aatgtggaaa gaaagaagac    540

attgttattc cgttgaataa agaaacagaa aaaatagaac atactgaaaa taatctaagt    600

tccaaccata gaagaagctg cagaagaaat gaagaaagtg atgatgattt agattttgat    660

attgatttag aagacacagg aggagaccat caaatgaatt aatatcactg tattaaaagt    720

ctgccgggca cagtggctca cgcctgtaat cccaacactt tgggaggcca aggagggtgg    780

atcacctgag gtcaggagtt cgagaccagc ctggccaaca tggcggaacc ccatctccac    840

taaaagtaca aaaaattagc tgggcgtggt ggctcatgcc tgtaatccca gctactcagg    900

aggctgaggc aggaggattg cttgaaccct ggaggcggag attgaagtga gctgagttcg    960

tgccattaca ctccagcctg ggtgacagag tgagactctg tctcaaaaaa aataaaataa   1020

aaagtcaatt tagaatgtga aattctgacc accttttggc tttgagtatt ttccaaaaga   1080

tatttgaaat cctaatgagg aaatcagaaa aagctatgga aaaatagaca aatttcatac   1140

atgaacaata taaattgtgt atattactta acatcaaact aaacaagatt cagaattgat   1200

ggttgtataa gaactagctc atgtaaaaat aaaataacat tattacattg cctcaaaaat   1260

tggtcctcgg taagtgcctt ttgataaatg atctcaaata aatgactcat agcaaaaaaa   1320

aaaaaaaa                                                            1328


<210>  2364
<211>  157
<212>  PRT
<213>  Homosapiens

<400>  2364

Met Ser Ser Gln Lys Gly Asn Val Ala Arg Ser Arg Pro Gln Lys His 
1               5                   10                  15      


Gln Asn Thr Phe Ser Phe Lys Asn Asp Lys Phe Asp Lys Ser Val Gln 
            20                  25                  30          


Thr Lys Lys Ile Asn Ala Lys Leu His Asp Gly Val Cys Gln Arg Cys 
        35                  40                  45              


Lys Glu Val Leu Glu Trp Arg Val Lys Tyr Ser Lys Tyr Lys Pro Leu 
    50                  55                  60                  


Ser Lys Pro Lys Lys Cys Val Lys Cys Leu Gln Lys Thr Val Lys Asp 
65                  70                  75                  80  


Ser Tyr His Ile Met Cys Arg Pro Cys Ala Cys Glu Leu Glu Val Cys 
                85                  90                  95      


Ala Lys Cys Gly Lys Lys Glu Asp Ile Val Ile Pro Leu Asn Lys Glu 
            100                 105                 110         


Thr Glu Lys Ile Glu His Thr Glu Asn Asn Leu Ser Ser Asn His Arg 
        115                 120                 125             


Arg Ser Cys Arg Arg Asn Glu Glu Ser Asp Asp Asp Leu Asp Phe Asp 
    130                 135                 140                 


Ile Asp Leu Glu Asp Thr Gly Gly Asp His Gln Met Asn 
145                 150                 155         


<210>  2365
<211>  1570
<212>  DNA
<213>  Homosapiens

<400>  2365
atgggggtgg gattcactga gctagaatac ttggctccct ggcttcggcc ccccttttca     60

gtggatcaga gtgtcgcttt cagttgtaac ggacttcatc acatcacaaa ttgtactcgt    120

tctcatcctt ttaagaaagt tcagacccag gaaaatttcc atagtacctt aatgaaaaag    180

atagaaatca gtgggacgtg tctttccttt catctccttt tcggcttgga aatcagaatg    240

agaaggattg tttttgctgg tgttatctta ttccgcctct taggtgttat cttattccgc    300

ctcttaggtg ttatcttatt cggccgctta ggtgacctgg gaacctgcca gacaaaacct    360

ggtcagtact ggaaagaaga ggtccacatt caagatgttg gaggtttgat ttgcagagca    420

tgcaatcttt cactgccctt ccatggatgt cttttagacc tgggaacctg ccaggcagaa    480

cctggtcagt actgtaaaga agaggtccac attcaaggtg gcattcaatg gtattcagtc    540

aaaggctgca caaagaacac atcagagtgc ttcaagagta ctctcgtcaa gagaattctg    600

caactgcatg aacttgtaac tactcactgc tgcaatcatt ctttgtgcaa tttctgagtc    660

agtggcccat atctaaaatg cttggcagat caatcagtct cgaagcctga cctggctatc    720

acaaaatgat ggctattgtc aattagccca cttcagaaac ctcagaccct tgtaggtaga    780

aggaattttg atctgaaatt gactttggtt ttcaatattc ccaatatctc ccccaccacc    840

tccaactcat ctgagaaata gccctttcaa caccatttct ctcctctcct ccttctgctt    900

aatttacctt cctaccacaa ggctacaaag aaggaaaaat gttagtgatt ctccaagtca    960

aactaggcat gtcacctcta actactttca tttccctcaa taattccata ctccaaaata   1020

tggttacaaa tgtttcacaa gacagcaagt gacctgagaa tattcatttg gtttccaaag   1080

caaactgcct tgctcctttg gggtgattta tggtatagaa gaaactgact taacatatac   1140

tatagggaaa aaataagcca tgaatcagca agccaggcct gcgggaaaag tatgaaccca   1200

aacaggaaag ggctgaggca ggtggtaggg ctggcactta tttcttccat ctgcctcaga   1260

gtttatccaa attttgaatt ttccgtacct taaccatgcc taaatgcttt ggcttgttca   1320

attttggcag attaagcagt tcaaggtaag cagagaagta agttcccaac cacaaggaat   1380

ttaaaaggag taggaacgta ctttgaacta catttcccat tttgcgatca ttacgtcttc   1440

tattacaatg ccctactttg gcagcatgaa gagtactgca ttaatttaat ttaatttaaa   1500

atttaattta aaactgtctt tctctgtatt ttcaggagtt tgaaaattca aaaaataaat   1560

aataaatgtc                                                          1570


<210>  2366
<211>  218
<212>  PRT
<213>  Homosapiens

<400>  2366

Met Gly Val Gly Phe Thr Glu Leu Glu Tyr Leu Ala Pro Trp Leu Arg 
1               5                   10                  15      


Pro Pro Phe Ser Val Asp Gln Ser Val Ala Phe Ser Cys Asn Gly Leu 
            20                  25                  30          


His His Ile Thr Asn Cys Thr Arg Ser His Pro Phe Lys Lys Val Gln 
        35                  40                  45              


Thr Gln Glu Asn Phe His Ser Thr Leu Met Lys Lys Ile Glu Ile Ser 
    50                  55                  60                  


Gly Thr Cys Leu Ser Phe His Leu Leu Phe Gly Leu Glu Ile Arg Met 
65                  70                  75                  80  


Arg Arg Ile Val Phe Ala Gly Val Ile Leu Phe Arg Leu Leu Gly Val 
                85                  90                  95      


Ile Leu Phe Arg Leu Leu Gly Val Ile Leu Phe Gly Arg Leu Gly Asp 
            100                 105                 110         


Leu Gly Thr Cys Gln Thr Lys Pro Gly Gln Tyr Trp Lys Glu Glu Val 
        115                 120                 125             


His Ile Gln Asp Val Gly Gly Leu Ile Cys Arg Ala Cys Asn Leu Ser 
    130                 135                 140                 


Leu Pro Phe His Gly Cys Leu Leu Asp Leu Gly Thr Cys Gln Ala Glu 
145                 150                 155                 160 


Pro Gly Gln Tyr Cys Lys Glu Glu Val His Ile Gln Gly Gly Ile Gln 
                165                 170                 175     


Trp Tyr Ser Val Lys Gly Cys Thr Lys Asn Thr Ser Glu Cys Phe Lys 
            180                 185                 190         


Ser Thr Leu Val Lys Arg Ile Leu Gln Leu His Glu Leu Val Thr Thr 
        195                 200                 205             


His Cys Cys Asn His Ser Leu Cys Asn Phe 
    210                 215             


<210>  2367
<211>  5451
<212>  DNA
<213>  Homosapiens

<400>  2367
gtagggagcc agcccctggg cgcggcctgc agggtaccgg caaccgcccg ggtaagcggg     60

ggcaggacaa ggccggagcc tgtgtccgcc cggcagccgc ccgcagctgc agagagtccc    120

gctgcgtctc cgccgcgtgc gccctcctcg accagcagac ccgcgctgcg ctccgccgct    180

gacatgtgtg ccgctcagat gccgcccctg gcgcacatct tccgagggac gttcgtccac    240

tccacctgga cctgccccat ggaggtgctg cgggatcacc tcctcggcgt gagcgacagc    300

ggcaaaatag tgtttttaga agaagcatct caacaggaaa aactggccaa agaatggtgc    360

ttcaagccgt gtgaaataag agaactgagc caccatgagt tcttcatgcc tgggctggtt    420

gatacacaca tccatgcctc tcagtattcc tttgctggaa gtagcataga cctgccactc    480

ttggagtggc tgaccaagta cacatttcct gcagaacaca gattccagaa catcgacttt    540

gcagaagaag tatataccag agttgtcagg agaacactaa agaatggaac aaccacagct    600

tgttactttg caacaattca cactgactca tctctgctcc ttgccgacat tacagataaa    660

tttggacagc gggcatttgt gggcaaagtt tgcatggatt tgaatgacac ttttccagaa    720

tacaaggaga ccactgagga atcgatcaag gaaactgaga gatttgtgtc agaaatgctc    780

caaaagaact attctagagt gaagcccata gtgacaccac gtttttccct ctcctgctct    840

gagactttga tgggtgaact gggcaacatt gctaaaaccc gtgatttgca cattcagagc    900

catataagtg aaaatcgtga tgaagttgaa gctgtgaaaa acttataccc cagttataaa    960

aactacacat ctgtgtatga taaaaacaat cttttgacaa ataagacagt gatggcacac   1020

ggctgctacc tctctgcaga agaactgaac gtattccatg aacgaggagc atccatcgca   1080

cactgtccca attctaattt atcgctcagc agtggatttc taaatgtgct agaagtcctg   1140

aaacatgaag tcaagatagg gctgggtaca gacgtggctg gtggctattc atattccatg   1200

cttgatgcaa tcagaagagc agtgatggtt tccaatatcc ttttaattaa taaggtaaat   1260

gagaaaagcc tcaccctcaa agaagtcttc agactagcta ctcttggagg aagccaagcc   1320

ctggggctgg atggtgagat tggaaacttt gaagtgggca aggaatttga tgccatcctg   1380

atcaacccca aagcatccga ctctcccatt gacctgtttt atggggactt ttttggtgat   1440

atttctgagg ctgttatcca gaagttcctc tatctaggag atgatcgaaa tattgaagag   1500

gtttatgtgg gcggaaagca ggtggttccg ttttccagct cagtgtaaga ccctcgggcg   1560

tctacaaagt tctcctggga ttagcgtggt tctgcatctc ccttgtgccc aggtggagtt   1620

agaaagtcaa aaaatagtac cttgttcttg ggatgactat ccctttctgt gtctagttac   1680

agtattcact tgacaaatag ttcgaaggaa gttgcactaa ttctcaactc tggttgagag   1740

ggttcataaa tttcatgaaa atatctccct ttggagctgc tcagacttac tttaagctca   1800

aacagaaggg aatgctatta ctggtggtgt tcctacggta agacttaagc aaagcctttt   1860

tcatatttga aaatgtggaa agaaaagatg ttcctaaaag gttagatatt ttgagctaat   1920

aattgcaaaa attagaagac tgaaaatgga cccatgagag tatattttta tgagggagca   1980

aaagttagac tgagaacaaa cgttagaaaa tcacttcaga ttgtgtttga aaattatata   2040

ctgagcatac taatttaaaa agagaacttg ttgaaattta aaacgtgttt ctaggttgac   2100

cttgtgtttt agaaatttgc acttaatgga atttgcattt cagagatgtg ttagtgttgt   2160

gctttgcctt ctttggcgat gaatgtcaga aattgaatgc cacatgcttt cataatatag   2220

ttttgtgctt caaagtgttt gacagaagtt gggtattaaa gatttaaagt ctcttaggaa   2280

tattattcat gtaactccat ggcataaata gttgtatttt tgtgtacttt aaaatcaact   2340

tataactgtg agatgttatt gcttccattt tattagaaga gaaacaaatt ccatgcttta   2400

tggaatttat gtagactgga gtcttcgtga actggggcaa atgctggcat ccaggagccg   2460

ccaatactaa caggacaggt tccattgcca tggcctattc cacccaaaca atatgttgta   2520

gtttctggaa attccatact cagatatcag tctgctagaa ctttaaaatg aaggacaaat   2580

cctgttaaag aaatattgtt aaaaatcttt aaaccctgtg tattgaaagc actctatttt   2640

ctaattttat ccagttttct gtttaactcc ttataatgtt taggatatta aaattttagg   2700

ataatgaaga gtacataatg tcctacttaa tatttatgtt aataggactt aattcttact   2760

agacatctag gaacattaca aagcaaagac tatttttatg cttccataac ctagaattaa   2820

aaccaaatta tgaccttatg ataaatcttt aagtattggt gtgaatgtta tttaaattct   2880

atatttttct tatttaatta caaatactat aaatgagcaa ggaaaaggaa tagactttct   2940

taatatatta taacactcat tcctagagct taggggtgac tctttaatat taccttatag   3000

tagaaacttt atgtaatata gctaactccg tatttacaga acaaaaaaac acagttcccc   3060

ctcctgtagt ataaatttta ttttcacata cttagctaat ttagcagtaa ttggcccagt   3120

tttttcccta atagaaatac ttttagattt gattatgtat acatgacacc taaagaggga   3180

acaaaagtta gttttatttt tttaataaac aacagagttt gttttgtgag ataagtatct   3240

tagtaaaccc aatttccagt cttagtctgt atttccaata tttctaattc ctgagccacg   3300

tcaaagatgc cttgccaaat ttctccccat ttctctacgg ggctagcaaa aatcttcagc   3360

tttatccctc aacccctgcc aaaggaactt gattacatgg tgtctaacca aatgagcagg   3420

cttaggaatt tagatgagat gtgtaagatt cacttacagg cagtagctgc ttctagcatt   3480

tgcaagatcc tacactttta ccttctttaa gggtgtacat tttgatgttg aacatcagtt   3540

ttcatgtaga cttaggactc atgtgcagta aatataaata agtgtagcat cagaagcagt   3600

aggaatggcc gtatacaacc atcctgttaa acatttaaat ttagctctga tagtgtgtta   3660

agacctgaat atctttccta gtaaaaatag gatgtgttga aatatttata tgtactttga   3720

tctctccaca tcacttataa cttatgtgtt ttatttctcc aagtgcggtg ttcctgaatg   3780

ttatgtatgc ttttttttct gtaccacagg cattatctat acctggggcc agattttctg   3840

cactttgaaa tgttgccttt gcctaatgta ggttgacttt ctgaattgtg gagaggcact   3900

tttccaagcc aatcttattt gtcacttttt gttttaatat cttgctctct gacaggaaag   3960

aaacaattca cttaccagcc tcctcacccc atcctccacc atttccttaa tgttccatgg   4020

tattttcaac ggaatacact ttgaaaggta aaaacaattc aaaagtatcg attatcataa   4080

attcacaaaa tatttttgca accagaacac aaaagcaggc tagtcagcta aggtaaattt   4140

cattttcaaa cgagagggaa acatgggaag taaaagatta ggatgtgaaa ggttgtccta   4200

aacagaccaa ggagactgtt ccctaattta ttctcttggc tggttctctc attgaattat   4260

cagaccccaa gaggagatat tggaacaggc tcccttcatg ccaagggtct ttctaagtta   4320

atactgtgag cattgagccc ccattaaaac tcttttttac ttcagaaaga attttacagg   4380

ttaaagggaa agaaatggtg ggaaactctc cccgtaatgc ttagccaact ttaaagtgta   4440

cccttcaata tccccattgg caactgcagc tgagatctta gagaggaaat ataaccggtg   4500

tgagatctag caatgcattt tgaatcttca ctccctacca ggctcttcct atttttaatc   4560

tcttcacctc agaactagac atatggagag ctttaaaggc aagctggaag gcacattgta   4620

tcaattctac cttgtgctat acgtaggaga gatccaaaat ttggatgctt ctggagactc   4680

ttagacatct tttcattgtt gtccattttt aaagttgatg attgctggaa acattcacac   4740

gcttaaaagc aatggtgtga gttattaatg ggtaaactaa gaagtgttat aggcaatgac   4800

ttgaaatggt ttttaaattg tatggattgt taagaattgt tgaaaaaaaa tttttttttt   4860

ttggacagct tcaaggagat gttagcaatt tcagatatac tagccagttt aggtatgact   4920

ttggaagtgc agaaacagaa ggatactgtt agaaaatcct aacattggtc tccgtgcatg   4980

tgttcacacc tggtctcact gcctttcctt cccacagacc tgagtgtgaa agactgagag   5040

ttgaggagtt actttgtgga tcttgtccaa atttagtgaa atgtggaagt caaccagacc   5100

aatgatggaa ttaaatgtaa attccaagag ggctttcaca gtccacaggg ttcaaatgac   5160

ttgggtaaca gaagttattc ttagcttacc tgttatgtga cagtgattta cctgtccatt   5220

tccaacccaa aagcctgtca gaaagcattc tttagagaaa accactttac atttgttgtt   5280

aaactcctga tcgctactct taagaatata catgtatgta ttcataggaa cattttttct   5340

caatatttgt atgattcgct tactgttatt gtgctgagtg agctcctgtg tgcttcagac   5400

aaaaataaat gagactttgt gtttacgtta aaaaaaaaaa aaaaaaaaaa a            5451


<210>  2368
<211>  454
<212>  PRT
<213>  Homosapiens

<400>  2368

Met Cys Ala Ala Gln Met Pro Pro Leu Ala His Ile Phe Arg Gly Thr 
1               5                   10                  15      


Phe Val His Ser Thr Trp Thr Cys Pro Met Glu Val Leu Arg Asp His 
            20                  25                  30          


Leu Leu Gly Val Ser Asp Ser Gly Lys Ile Val Phe Leu Glu Glu Ala 
        35                  40                  45              


Ser Gln Gln Glu Lys Leu Ala Lys Glu Trp Cys Phe Lys Pro Cys Glu 
    50                  55                  60                  


Ile Arg Glu Leu Ser His His Glu Phe Phe Met Pro Gly Leu Val Asp 
65                  70                  75                  80  


Thr His Ile His Ala Ser Gln Tyr Ser Phe Ala Gly Ser Ser Ile Asp 
                85                  90                  95      


Leu Pro Leu Leu Glu Trp Leu Thr Lys Tyr Thr Phe Pro Ala Glu His 
            100                 105                 110         


Arg Phe Gln Asn Ile Asp Phe Ala Glu Glu Val Tyr Thr Arg Val Val 
        115                 120                 125             


Arg Arg Thr Leu Lys Asn Gly Thr Thr Thr Ala Cys Tyr Phe Ala Thr 
    130                 135                 140                 


Ile His Thr Asp Ser Ser Leu Leu Leu Ala Asp Ile Thr Asp Lys Phe 
145                 150                 155                 160 


Gly Gln Arg Ala Phe Val Gly Lys Val Cys Met Asp Leu Asn Asp Thr 
                165                 170                 175     


Phe Pro Glu Tyr Lys Glu Thr Thr Glu Glu Ser Ile Lys Glu Thr Glu 
            180                 185                 190         


Arg Phe Val Ser Glu Met Leu Gln Lys Asn Tyr Ser Arg Val Lys Pro 
        195                 200                 205             


Ile Val Thr Pro Arg Phe Ser Leu Ser Cys Ser Glu Thr Leu Met Gly 
    210                 215                 220                 


Glu Leu Gly Asn Ile Ala Lys Thr Arg Asp Leu His Ile Gln Ser His 
225                 230                 235                 240 


Ile Ser Glu Asn Arg Asp Glu Val Glu Ala Val Lys Asn Leu Tyr Pro 
                245                 250                 255     


Ser Tyr Lys Asn Tyr Thr Ser Val Tyr Asp Lys Asn Asn Leu Leu Thr 
            260                 265                 270         


Asn Lys Thr Val Met Ala His Gly Cys Tyr Leu Ser Ala Glu Glu Leu 
        275                 280                 285             


Asn Val Phe His Glu Arg Gly Ala Ser Ile Ala His Cys Pro Asn Ser 
    290                 295                 300                 


Asn Leu Ser Leu Ser Ser Gly Phe Leu Asn Val Leu Glu Val Leu Lys 
305                 310                 315                 320 


His Glu Val Lys Ile Gly Leu Gly Thr Asp Val Ala Gly Gly Tyr Ser 
                325                 330                 335     


Tyr Ser Met Leu Asp Ala Ile Arg Arg Ala Val Met Val Ser Asn Ile 
            340                 345                 350         


Leu Leu Ile Asn Lys Val Asn Glu Lys Ser Leu Thr Leu Lys Glu Val 
        355                 360                 365             


Phe Arg Leu Ala Thr Leu Gly Gly Ser Gln Ala Leu Gly Leu Asp Gly 
    370                 375                 380                 


Glu Ile Gly Asn Phe Glu Val Gly Lys Glu Phe Asp Ala Ile Leu Ile 
385                 390                 395                 400 


Asn Pro Lys Ala Ser Asp Ser Pro Ile Asp Leu Phe Tyr Gly Asp Phe 
                405                 410                 415     


Phe Gly Asp Ile Ser Glu Ala Val Ile Gln Lys Phe Leu Tyr Leu Gly 
            420                 425                 430         


Asp Asp Arg Asn Ile Glu Glu Val Tyr Val Gly Gly Lys Gln Val Val 
        435                 440                 445             


Pro Phe Ser Ser Ser Val 
    450                 


<210>  2369
<211>  7111
<212>  DNA
<213>  Homosapiens

<400>  2369
gcgtcagccc tcacgtcact tcgccagcag tagcagaggc ggcggcggcg gctcccggaa     60

ttgggttgga gcaggagcct cgctggctgc ttcgctcgcg ctctacgcgc tcagtccccg    120

gcggtagcag gagcctggac ccaggcgccg ccggcgggcg tgaggcgccg gagcccggcc    180

tcgaggtgca taccggaccc ccattcgcat ctaacaagga atctgcgccc cagagagtcc    240

cgggagcgcc gccggtcggt gcccggcgcg ccgggccatg cagcgacggc cgccgcggag    300

ctccgagcag cggtagcgcc cccctgtaaa gcggttcgct atgccggggc cactgtgaac    360

cctgccgcct gccggaacac tcttcgctcc ggaccagctc agcctctgat aagctggact    420

cggcacgccc gcaacaagca ccgaggagtt aagagagccg caagcgcagg gaaggcctcc    480

ccgcacgggt gggggaaagc ggccggtgca gcgcggggac aggcactcgg gctggcactg    540

gctgctaggg atgtcgtcct ggataaggtg gcatggaccc gccatggcgc ggctctgggg    600

cttctgctgg ctggttgtgg gcttctggag ggccgctttc gcctgtccca cgtcctgcaa    660

atgcagtgcc tctcggatct ggtgcagcga cccttctcct ggcatcgtgg catttccgag    720

attggagcct aacagtgtag atcctgagaa catcaccgaa attttcatcg caaaccagaa    780

aaggttagaa atcatcaacg aagatgatgt tgaagcttat gtgggactga gaaatctgac    840

aattgtggat tctggattaa aatttgtggc tcataaagca tttctgaaaa acagcaacct    900

gcagcacatc aattttaccc gaaacaaact gacgagtttg tctaggaaac atttccgtca    960

ccttgacttg tctgaactga tcctggtggg caatccattt acatgctcct gtgacattat   1020

gtggatcaag actctccaag aggctaaatc cagtccagac actcaggatt tgtactgcct   1080

gaatgaaagc agcaagaata ttcccctggc aaacctgcag atacccaatt gtggtttgcc   1140

atctgcaaat ctggccgcac ctaacctcac tgtggaggaa ggaaagtcta tcacattatc   1200

ctgtagtgtg gcaggtgatc cggttcctaa tatgtattgg gatgttggta acctggtttc   1260

caaacatatg aatgaaacaa gccacacaca gggctcctta aggataacta acatttcatc   1320

cgatgacagt gggaagcaga tctcttgtgt ggcggaaaat cttgtaggag aagatcaaga   1380

ttctgtcaac ctcactgtgc attttgcacc aactatcaca tttctcgaat ctccaacctc   1440

agaccaccac tggtgcattc cattcactgt gaaaggcaac cccaaaccag cgcttcagtg   1500

gttctataac ggggcaatat tgaatgagtc caaatacatc tgtactaaaa tacatgttac   1560

caatcacacg gagtaccacg gctgcctcca gctggataat cccactcaca tgaacaatgg   1620

ggactacact ctaatagcca agaatgagta tgggaaggat gagaaacaga tttctgctca   1680

cttcatgggc tggcctggaa ttgacgatgg tgcaaaccca aattatcctg atgtaattta   1740

tgaagattat ggaactgcag cgaatgacat cggggacacc acgaacagaa gtaatgaaat   1800

cccttccaca gacgtcactg ataaaaccgg tcgggaacat ctctcggtct atgctgtggt   1860

ggtgattgcg tctgtggtgg gattttgcct tttggtaatg ctgtttctgc ttaagttggc   1920

aagacactcc aagtttggca tgaaaggttt tgttttgttt cataagatcc cactggatgg   1980

gtagctgaaa taaaggaaaa gacagagaaa ggggctgtgg tgcttgttgg ttgatgctgc   2040

catgtaagct ggactcctgg gactgctgtt ggcttatccc gggaagtgct gcttatctgg   2100

ggttttctgg tagatgtggg cggtgtttgg aggctgtact atatgaagcc tgcatatact   2160

gtgagctgtg attggggaac accaatgcag aggtaactct caggcagcta agcagcacct   2220

caagaaaaca tgttaaatta atgcttctct tcttacagta gttcaaatac aaaactgaaa   2280

tgaaatccca ttggattgta cttctcttct gaaaagtgtg ctttttgacc ctactggaca   2340

tttattgact taattgcttc tgtttattaa aattgacctg caaagttaaa aaaaaattaa   2400

agttgagaac aggtataagt gcacactgaa tagtctaatc tacatgtaac acatatttta   2460

gtgtgatttt ctatactcta atcagcactg aattcagagg gtttgacttt ttcatctata   2520

acacagtgac taaaagagtt aagggtatat ataccatcac tttgggactt ggtagtatta   2580

ttaaaaggtt atttccttca ctgtcaataa aagtccaaat gtttagctta ggtctgagag   2640

tcaaacaatg ttaaggattg tcttaaagtt ccttagccag caaaacaaaa caaaacaaaa   2700

caaacaaatg aaaaacgttt aaaaagaaga agaagaaaaa aaacaagaac aagcagcaac   2760

agctgttttg ttggggctat agatttaagt taggcatagt caatttcaga ataactaaga   2820

gtggaatata tgcatatggt gaaattataa ccttgccctt ttttatttgc cctctgcgat   2880

ccacctgctt tttagaagtc tgccgagtga gaaggccaca gtatctcatg ctgtttgcat   2940

tacagaactg cagcttttct actctgaaaa ggcctgggag cagaatggct ggcctgctgt   3000

gagcaggaga ggagattcta agaaggatag tcccccctac aacatactgt catactgctg   3060

ggttttcatg ggtaggaaag cttgtcctga ccccagcagc aaagaggtgg caggtcgcta   3120

atgaatatat gctttataat gtccttcttc attgctgaga gggcagcctt agagctgtgg   3180

atttctgcat cccccctgag tctgacccat ggacacctgt ttcattcact ttagcatcac   3240

agtgaccttt gtatgctctg ttcagtctgt gtcaggcagt atgcttgtcc tgaagagagg   3300

tttggctatc cccaccccac cccaccccac cctgttcctt ttttatcagg aggacttcag   3360

agccaggcct gcagcatttt gtttgaaaac acaatcagct ctgacagtta gacatgcaca   3420

cagacgccat agctggattg gaaacattga tgttttaaaa atttattttt tttggaaata   3480

gttgcacaaa tgctgcaatt tagctttaag gttctataga tttttaacta gtccaacaca   3540

gtcagaaaca ttgttttgaa tcctctgtaa accaaggcat taatcttaat aaaccaggat   3600

ccatttaggt accacttgat ataaaaagga tatccataat gaatatttta tactgcatcc   3660

tttacattag ccactaaata cgttattgct tgatgaagac ctttcacaga atcctatgga   3720

ttgcagcatt tcacttggct acttcatacc catgccttaa agaggggcag tttctcaaaa   3780

gcagaaacat gccgccagtt ctcaagtttt cctcctaact ccatttgaat gtaagggcag   3840

ctggccccca atgtggggag gtccgaacat tttctgaatt cccattttct tgttcgcggc   3900

taaatgacag tttctgtcat tacttagatt ccgatctttc ccaaaggtgt tgatttacaa   3960

agaggccagc taatagcaga aatcatgacc ctgaaagaga gatgaaattc aagctgtgag   4020

ccaggcagga gctcagtatg gcaaaggttc ttgagaatca gccatttggt acaaaaaaga   4080

tttttaaagc ttttatgtta taccatggag ccatagaaag gctatggatt gtttaagaac   4140

tattttaaag tgttccagac ccaaaaagga aaaataaaaa aaaaggaata tttgtaccca   4200

acagctagaa ggattgcaag gtagattttt gttttaaaat ggagagaagt ggacagataa   4260

ggccatttaa tatatcaaag atcagttgac atctcctagg gaatgatgaa aacagcaggc   4320

tattagaaaa ttatttcata tagttctcgt gttcttttct tttttttaat ccctgaaggg   4380

atgatcagta acatagcttc tcttttctgt actctagacc accccttttc atcattttgc   4440

tttttatgtc tcccataaga aatgtgcttt ttagagcttc ctaatgcatg tgttgcatta   4500

ttgcagcatt agaaaaggag aggtagcatt tttgctgaaa tcgggcctgt cactctccaa   4560

taaaggttct ggcacttcaa tgccaggcag gtctcctaaa tgaacagaat gatctgtgtg   4620

agccgatgcc tgcccttcca gaggggccac tgtccccagc cgcagccaac tgtgtcccac   4680

aggaatggga gcctaggttt ccaaatcttg tgattcttta ggagaaacat gaaacctgga   4740

tttcgtgtga aatgtcccga ttgttaaaaa gttggctcaa ttatttttaa aacattttgt   4800

aagccaacaa aagtctgtgg gctgccagtt tattactttt gtcttaaaac atgatcattg   4860

ttctctcacg gtatccttct gtcttcccgt tgcaaattca cttttctttc ttcctgacat   4920

tgccattgag ggctttgtta ccacaagcta agaaactgag tttaacagcc cagttatctg   4980

caacatgtca attacctttg ctcctctcct gtgattccca ccatgctgtg accctcagct   5040

gtctcccttt gctgggaatt ctgcaccaat gtctcccctc aacccattcc ctggttggtc   5100

ctactcccgt gtggccagag acatcctagc aaatccttcc tcctattata tctgacacta   5160

atttcttttc aacagcgctc atgtctcttg gcccagtcag gtgctgccag gtttagatag   5220

gaaagtacat gtcccatttt catgggtgcc cttaatgtgg tccacgtcct atatcttatt   5280

atatttactc atggctcaat gggggcctcc agagaccctc tcaggctgct gagctagact   5340

aaggaatgca tccaccgtca tcacatgaga cactgactct gtgacgacaa aagtacaaac   5400

agtctgaggc taagaaaggt tcatctcaca acaggaaaaa caaatctcaa cacacattag   5460

agataattga ttcaggggtt ttctctccca gtctcccagc agggactgat ttcatttctg   5520

acccactagg ttttctttcc agaaataggt agcaaggaca agaactaaac aatcccagcc   5580

ccacccagca acacagaaca caggagtttg cttttggctt ctcactctcc aagtaaccct   5640

gaattaggcc cagaatggct gaggcttgga gcatctcctc agacagagca gaggcgacac   5700

ctcttcaggg gtgtgtggag taaatagctc gaagagctga agacagaaaa ccagtttcac   5760

gccaggtgcg agagagagca taatggaggg aagcccgctt tctctctcct cttcttttct   5820

ctttatttct ttagagcact tgactttttt ttctctctct ctctagtatt ctaaactgac   5880

cccatgacca actgagaatt tatttttgtt tcattggttg tttcacagaa ttagaacaca   5940

cacgactttt tattcctcca ttgcaaaatg gaatcaagat actacacaag acctgtgctt   6000

tcttcctttg catgatttac acctccgcct gttttggtgc tagctgtcta gaacttctct   6060

cttggtttga atctgattcc ttcacactac actagaagtt tatttcatct tgttttgtct   6120

agactccaga tacagaggga cagctggact gaggacaagc aattccatct agcatagggt   6180

ctctcagggt tggtgcatcc agccacatgg gcagggccag tcacatctag tctatgtccc   6240

cagagccctt ggagttgcgc agcttagctg acttgactcc aaggaaatta gtacagaagt   6300

aaccactcta ttaagtgtgt tctgctatgt tcacatgcct gtagtacctg caaaccatgc   6360

caggttcatc taaagacata ggggaagatt aaggactctt ttggacagac catgaattga   6420

atttgctgcc aggtgctgcc agactgaatt tggctgacag aactcccagc ccaggaaagt   6480

tccatgacaa tgactgtcgc agaaggaaat ttcccactaa agtcagtcca ttttcaagtt   6540

ttggtcttca gagacaaaag aacgtcccag ccacctgatt ttgatggtga ggtaactcta   6600

agttgaattc aggctagtgt tgcagtatag ctttggcatg ttcatgagtg agcacccaga   6660

atgtgttgaa ccaaccccca cccctaacta ctgactatga ctgcagtggg tttttatggg   6720

gaaaaaaagt gtgaaaagca aaaagaaagg aacagagatt ttttatcacc tttattgtaa   6780

gacagtccat ttatgaattg agtataaaca catacaaagt aacaagagat tcctaagaaa   6840

cgcaaatcct tgagtttcac gcacttcatg ttcaaccatt tgctgtaatc cagaggcagc   6900

ctgtgaatca ttctcatgcc ctgttttttt tttttttttc ctataatgtt ctgggtttaa   6960

aagccatctt ttccacattt tctgtaaata atggataatc attttaaaaa tttttatttt   7020

tagtgctgtt ttaacaatgt agatagatca taaatgtact tgctgaattc aatcattttt   7080

aacaagccaa taaagtttga taattcatct c                                  7111


<210>  2370
<211>  477
<212>  PRT
<213>  Homosapiens

<400>  2370

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Phe Val Leu Phe His Lys Ile Pro Leu Asp Gly 
465                 470                 475         


<210>  2371
<211>  5560
<212>  DNA
<213>  Homosapiens

<400>  2371
aagacggatt ctcagacaag gcttgcaaat gccccgcagc catcatttaa ctgcacccgc     60

agaatagtta cggtttgtca cccgaccctc ccggatcgcc taatttgtcc ctagtgagac    120

cccgaggctc tgcccgcgcc tggcttcttc gtagctggat gcatatcgtg ctccgggcag    180

cgcgggcgca gggcacgcgt tcgcgcacac cctagcacac atgaacacgc gcaagagctg    240

aaccaagcac ggtttccatt tcaaaaaggg agacagcctc taccgcgatt gtagaagaga    300

ctgtggtgtg aattagggac cgggaggcgt cgaacggagg aacggttcat cttagagact    360

aattttctgg agtttctgcc cctgctctgc gtcagccctc acgtcacttc gccagcagta    420

gcagaggcgg cggcggcggc tcccggaatt gggttggagc aggagcctcg ctggctgctt    480

cgctcgcgct ctacgcgctc agtccccggc ggtagcagga gcctggaccc aggcgccgcc    540

ggcgggcgtg aggcgccgga gcccggcctc gaggtgcata ccggaccccc attcgcatct    600

aacaaggaat ctgcgcccca gagagtcccg ggagcgccgc cggtcggtgc ccggcgcgcc    660

gggccatgca gcgacggccg ccgcggagct ccgagcagcg gtagcgcccc cctgtaaagc    720

ggttcgctat gccggggcca ctgtgaaccc tgccgcctgc cggaacactc ttcgctccgg    780

accagctcag cctctgataa gctggactcg gcacgcccgc aacaagcacc gaggagttaa    840

gagagccgca agcgcaggga aggcctcccc gcacgggtgg gggaaagcgg ccggtgcagc    900

gcggggacag gcactcgggc tggcactggc tgctagggat gtcgtcctgg ataaggtggc    960

atggacccgc catggcgcgg ctctggggct tctgctggct ggttgtgggc ttctggaggg   1020

ccgctttcgc ctgtcccacg tcctgcaaat gcagtgcctc tcggatctgg tgcagcgacc   1080

cttctcctgg catcgtggca tttccgagat tggagcctaa cagtgtagat cctgagaaca   1140

tcaccgaaat tttcatcgca aaccagaaaa ggttagaaat catcaacgaa gatgatgttg   1200

aagcttatgt gggactgaga aatctgacaa ttgtggattc tggattaaaa tttgtggctc   1260

ataaagcatt tctgaaaaac agcaacctgc agcacatcaa ttttacccga aacaaactga   1320

cgagtttgtc taggaaacat ttccgtcacc ttgacttgtc tgaactgatc ctggtgggca   1380

atccatttac atgctcctgt gacattatgt ggatcaagac tctccaagag gctaaatcca   1440

gtccagacac tcaggatttg tactgcctga atgaaagcag caagaatatt cccctggcaa   1500

acctgcagat acccaattgt ggtttgccat ctgcaaatct ggccgcacct aacctcactg   1560

tggaggaagg aaagtctatc acattatcct gtagtgtggc aggtgatccg gttcctaata   1620

tgtattggga tgttggtaac ctggtttcca aacatatgaa tgaaacaagc cacacacagg   1680

gctccttaag gataactaac atttcatccg atgacagtgg gaagcagatc tcttgtgtgg   1740

cggaaaatct tgtaggagaa gatcaagatt ctgtcaacct cactgtgcat tttgcaccaa   1800

ctatcacatt tctcgaatct ccaacctcag accaccactg gtgcattcca ttcactgtga   1860

aaggcaaccc caaaccagcg cttcagtggt tctataacgg ggcaatattg aatgagtcca   1920

aatacatctg tactaaaata catgttacca atcacacgga gtaccacggc tgcctccagc   1980

tggataatcc cactcacatg aacaatgggg actacactct aatagccaag aatgagtatg   2040

ggaaggatga gaaacagatt tctgctcact tcatgggctg gcctggaatt gacgatggtg   2100

caaacccaaa ttatcctgat gtaatttatg aagattatgg aactgcagcg aatgacatcg   2160

gggacaccac gaacagaagt aatgaaatcc cttccacaga cgtcactgat aaaaccggtc   2220

gggaacatct ctcggtctat gctgtggtgg tgattgcgtc tgtggtggga ttttgccttt   2280

tggtaatgct gtttctgctt aagttggcaa gacactccaa gtttggcatg aaaggcccag   2340

cctccgttat cagcaatgat gatgactctg ccagcccact ccatcacatc tccaatggga   2400

gtaacactcc atcttcttcg gaaggtggcc cagatgctgt cattattgga atgaccaaga   2460

tccctgtcat tgaaaatccc cagtactttg gcatcaccaa cagtcagctc aagccagaca   2520

catttgttca gcacatcaag cgacataaca ttgttctgaa aagggagcta ggcgaaggag   2580

cctttggaaa agtgttccta gctgaatgct ataacctctg tcctgagcag gacaagatct   2640

tggtggcagt gaagaccctg aaggatgcca gtgacaatgc acgcaaggac ttccaccgtg   2700

aggccgagct cctgaccaac ctccagcatg agcacatcgt caagttctat ggcgtctgcg   2760

tggagggcga ccccctcatc atggtctttg agtacatgaa gcatggggac ctcaacaagt   2820

tcctcagggc acacggccct gatgccgtgc tgatggctga gggcaacccg cccacggaac   2880

tgacgcagtc gcagatgctg catatagccc agcagatcgc cgcgggcatg gtctacctgg   2940

cgtcccagca cttcgtgcac cgcgatttgg ccaccaggaa ctgcctggtc ggggagaact   3000

tgctggtgaa aatcggggac tttgggatgt cccgggacgt gtacagcact gactactaca   3060

gggtcggtgg ccacacaatg ctgcccattc gctggatgcc tccagagagc atcatgtaca   3120

ggaaattcac gacggaaagc gacgtctgga gcctgggggt cgtgttgtgg gagattttca   3180

cctatggcaa acagccctgg taccagctgt caaacaatga ggtgatagag tgtatcactc   3240

agggccgagt cctgcagcga ccccgcacgt gcccccagga ggtgtatgag ctgatgctgg   3300

ggtgctggca gcgagagccc cacatgagga agaacatcaa gggcatccat accctccttc   3360

agaacttggc caaggcatct ccggtctacc tggacattct aggctagggc ccttttcccc   3420

agaccgatcc ttcccaacgt actcctcaga cgggctgaga ggatgaacat cttttaactg   3480

ccgctggagg ccaccaagct gctctccttc actctgacag tattaacatc aaagactccg   3540

agaagctctc gagggaagca gtgtgtactt cttcatccat agacacagta ttgacttctt   3600

tttggcatta tctctttctc tctttccatc tcccttggtt gttccttttt ctttttttaa   3660

attttctttt tctttttttt ttcgtcttcc ctgcttcacg attcttaccc tttcttttga   3720

atcaatctgg cttctgcatt actattaact ctgcatagac aaaggcctta acaaacgtaa   3780

tttgttatat cagcagacac tccagtttgc ccaccacaac taacaatgcc ttgttgtatt   3840

cctgcctttg atgtggatga aaaaaaggga aaacaaatat ttcacttaaa ctttgtcact   3900

tctgctgtac agatatcgag agtttctatg gattcacttc tatttattta ttattattac   3960

tgttcttatt gtttttggat ggcttaagcc tgtgtataaa aaagaaaact tgtgttcaat   4020

ctgtgaagcc tttatctatg ggagattaaa accagagaga aagaagattt attatgaacc   4080

gcaatatggg aggaacaaag acaaccactg ggatcagctg gtgtcagtcc ctacttagga   4140

aatactcagc aactgttagc tgggaagaat gtattcggca ccttcccctg aggacctttc   4200

tgaggagtaa aaagactact ggcctctgtg ccatggatga ttcttttccc atcaccagaa   4260

atgatagcgt gcagtagaga gcaaagatgg cttccgtgag acacaagatg gcgcatagtg   4320

tgctcggaca cagttttgtc ttcgtaggtt gtgatgatag cactggtttg tttctcaagc   4380

gctatccaca gaacctttgt caacttcagt tgaaaagagg tggattcatg tccagagctc   4440

atttcggggt caggtgggaa agccaagaac ttggaaaaga taagacaagc tataaattcg   4500

gaggcaagtt tcttttacaa tgaacttttc agatctcact tccctccgac ccctaacttc   4560

catgcccacc cgtcctttta actgtgcaag caaaattgtg catggtcttc gtcgattaat   4620

accttgtgtg cagacactac tgctccagac gtcgtttccc tgataggtag agcagatcca   4680

taaaaaggta tgacttatac aattagggga agctaatgga gtttattagc tgagtatcaa   4740

tgtctctgcg ttgtacggtg gtgatgggtt ttaatgaata tggaccctga agcctggaaa   4800

tcctcatcca cgtcgaaccc acaggactgt gggaagggca gaatcaatcc ctaagggaaa   4860

ggaaacctca ccctgagggc atcacatgca ctcatgttca gtgtacacag gtcaagtccc   4920

ttgctctggg ctctagttgg gagagtggtt tcattccaag tgtactccat tgtcagtatg   4980

ctgtttttgt ttccttcact ccattcaaaa agtcaaaata caaaatttgg cacagcatgc   5040

caacgggagg ctgtgcccag accaagcact ggaagtgtgc ttctaggcat agtcattggt   5100

tttgcaaaaa gagggctcaa atttaaatag aaatttacag ctatttgaat ggtcagatat   5160

accaagaaag aaaaatattt ctgttcctca agaaaacttg ctaccctctg tgaggggaat   5220

tttgctaaac ttgacatctt tataacatga gccagattga aagggagtga ttttcattca   5280

tcttaggtca tgttatttca tatttgtttc tgaaggtgcg atagctctgt tttaggtttt   5340

gcttgcgcct gttaattact ggaacacctt atttttcatt aaaggctttg aaagccaatt   5400

ctcaaaaatt caaaagtgca aattaacaga acaaaaggaa atccagtagc aactgcagtc   5460

aagcgaggga gttgacaaga taaaccttac gtccattcaa gttatatgct ggcctatgag   5520

agatgagagt tgggtcgttt gttctctttg ttgatgattt                         5560


<210>  2372
<211>  822
<212>  PRT
<213>  Homosapiens

<400>  2372

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
                485                 490                 495     


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
        515                 520                 525             


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
                565                 570                 575     


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
        595                 600                 605             


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
625                 630                 635                 640 


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
                645                 650                 655     


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
            660                 665                 670         


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
        675                 680                 685             


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
    690                 695                 700                 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
705                 710                 715                 720 


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
                725                 730                 735     


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
            740                 745                 750         


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
        755                 760                 765             


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
    770                 775                 780                 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
785                 790                 795                 800 


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
                805                 810                 815     


Tyr Leu Asp Ile Leu Gly 
            820         


<210>  2373
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  2373
aagacggatt ctcagacaag gcttgcaaat gccccgcagc catcatttaa ctgcacccgc     60

agaatagtta cggtttgtca cccgaccctc ccggatcgcc taatttgtcc ctagtgagac    120

cccgaggctc tgcccgcgcc tggcttcttc gtagctggat gcatatcgtg ctccgggcag    180

cgcgggcgca gggcacgcgt tcgcgcacac cctagcacac atgaacacgc gcaagagctg    240

aaccaagcac ggtttccatt tcaaaaaggg agacagcctc taccgcgatt gtagaagaga    300

ctgtggtgtg aattagggac cgggaggcgt cgaacggagg aacggttcat cttagagact    360

aattttctgg agtttctgcc cctgctctgc gtcagccctc acgtcacttc gccagcagta    420

gcagaggcgg cggcggcggc tcccggaatt gggttggagc aggagcctcg ctggctgctt    480

cgctcgcgct ctacgcgctc agtccccggc ggtagcagga gcctggaccc aggcgccgcc    540

ggcgggcgtg aggcgccgga gcccggcctc gaggtgcata ccggaccccc attcgcatct    600

aacaaggaat ctgcgcccca gagagtcccg ggagcgccgc cggtcggtgc ccggcgcgcc    660

gggccatgca gcgacggccg ccgcggagct ccgagcagcg gtagcgcccc cctgtaaagc    720

ggttcgctat gccggggcca ctgtgaaccc tgccgcctgc cggaacactc ttcgctccgg    780

accagctcag cctctgataa gctggactcg gcacgcccgc aacaagcacc gaggagttaa    840

gagagccgca agcgcaggga aggcctcccc gcacgggtgg gggaaagcgg ccggtgcagc    900

gcggggacag gcactcgggc tggcactggc tgctagggat gtcgtcctgg ataaggtggc    960

atggacccgc catggcgcgg ctctggggct tctgctggct ggttgtgggc ttctggaggg   1020

ccgctttcgc ctgtcccacg tcctgcaaat gcagtgcctc tcggatctgg tgcagcgacc   1080

cttctcctgg catcgtggca tttccgagat tggagcctaa cagtgtagat cctgagaaca   1140

tcaccgaaat tttcatcgca aaccagaaaa ggttagaaat catcaacgaa gatgatgttg   1200

aagcttatgt gggactgaga aatctgacaa ttgtggattc tggattaaaa tttgtggctc   1260

ataaagcatt tctgaaaaac agcaacctgc agcacatcaa ttttacccga aacaaactga   1320

cgagtttgtc taggaaacat ttccgtcacc ttgacttgtc tgaactgatc ctggtgggca   1380

atccatttac atgctcctgt gacattatgt ggatcaagac tctccaagag gctaaatcca   1440

gtccagacac tcaggatttg tactgcctga atgaaagcag caagaatatt cccctggcaa   1500

acctgcagat acccaattgt ggtttgccat ctgcaaatct ggccgcacct aacctcactg   1560

tggaggaagg aaagtctatc acattatcct gtagtgtggc aggtgatccg gttcctaata   1620

tgtattggga tgttggtaac ctggtttcca aacatatgaa tgaaacaagc cacacacagg   1680

gctccttaag gataactaac atttcatccg atgacagtgg gaagcagatc tcttgtgtgg   1740

cggaaaatct tgtaggagaa gatcaagatt ctgtcaacct cactgtgcat tttgcaccaa   1800

ctatcacatt tctcgaatct ccaacctcag accaccactg gtgcattcca ttcactgtga   1860

aaggcaaccc caaaccagcg cttcagtggt tctataacgg ggcaatattg aatgagtcca   1920

aatacatctg tactaaaata catgttacca atcacacgga gtaccacggc tgcctccagc   1980

tggataatcc cactcacatg aacaatgggg actacactct aatagccaag aatgagtatg   2040

ggaaggatga gaaacagatt tctgctcact tcatgggctg gcctggaatt gacgatggtg   2100

caaacccaaa ttatcctgat gtaatttatg aagattatgg aactgcagcg aatgacatcg   2160

gggacaccac gaacagaagt aatgaaatcc cttccacaga cgtcactgat aaaaccggtc   2220

gggaacatct ctcggtctat gctgtggtgg tgattgcgtc tgtggtggga ttttgccttt   2280

tggtaatgct gtttctgctt aagttggcaa gacactccaa gtttggcatg aaagatttct   2340

catggtttgg atttgggaaa gtaaaatcaa gacaaggtgt tggcccagcc tccgttatca   2400

gcaatgatga tgactctgcc agcccactcc atcacatctc caatgggagt aacactccat   2460

cttcttcgga aggtggccca gatgctgtca ttattggaat gaccaagatc cctgtcattg   2520

aaaatcccca gtactttggc atcaccaaca gtcagctcaa gccagacaca tggcccagag   2580

gttcccccaa gaccgcctga taataatttg gtatttggag gctcctgtgt cactgcagga   2640

actaaaggag gctaaatcca tgcctgatgg aggagaagag ttctatggtt atctgcaaat   2700

tctggccaga caacatcttg acgtcactcc ttagcttcca taacctagcc aagcaagaag   2760

ttgcctttcc aagacaaagc agtgtgctct aatgactaac ccctcaaagt actatgccac   2820

tttaactata gacccatctc ctcgatcaat caggatggca agatggagct gaggagctca   2880

gcaacatcaa gtctggagtt ggtctttaac tcaactagct cgtttagacg tgtctgaaca   2940

ccacatcacc tgacagcacg gggtggtttc ccagtaaaat ttacaaactc agctcaaggg   3000

cagctgtgtt gctttccttt ccttgactgc tgagaaactt tttgacaggg aacaatggaa   3060

acacaccttc tgagctgaaa caaacaaaca gaaacaaaac atactaacca gcaaaatccc   3120

caaatcatca atcttgggtt ctcttgaagg gcaggagtgt gttttatctt ctcccgtcgg   3180

agcaaacact atagatgtcc tccctaaaat tctgtcttcc ctagagcagc cttgtaaatt   3240

agctagggtc ctagggttga ggcctaaatc aacttaaaat tgtctctaaa tatgtacctg   3300

gatgtgtttg tacttgcaga gcatgccctc ttcatgtgcc tagggctagt aactccctgt   3360

ggcagaggca tgtaaagtat tctgactttt tttttttcaa cttaattcca tttccaatga   3420

aatggatttt taaaaatttt ctccagagtg tgccatactt ctccagctat tatagttaat   3480

gtgtgtgtat ccttgtgtat atgtgtgttt gtgtgtgcat atgtgttttc ctagtggtta   3540

catgcttact aggcaattat gtaaataagc acagattcat aggccagcta ggcctgagga   3600

aagaagacat tataaaggga gggagtattt taacattagc taaagctatc acacaaggca   3660

cccattctgc tcccctcaac agccacagcc cacttcgtcc ttgtcttacc aataagggga   3720

aaggctggag gtgatatttt tcacagaacc gcagaggttt tgaacatatt tgcaacatta   3780

ctttgagtac acatgagcaa aaattctgaa ttacatccag gaccccagaa gctcattaga   3840

tcaaagagtg cggggcccct cagagttacc agagattatc tgcagacttc agtgcaatcg   3900

aatgaccatg gtccattttg atggtcagag gtaggactga aaaacgggta gaaacaattg   3960

ctttagcgct tccttctgta ctttgcctat taatgttttg tctttcaaaa atatattttc   4020

tcctaattgt ttaattggcc aaataatggc tgctttggga gttgtttgta tgccttggaa   4080

ggccatggcc tgcactttaa aaataagcta agtccattct gcccagcacg agcattagga   4140

cagagaatgc acttatttta ggatccttaa aaattgcttc ttttatggca cactgggttg   4200

acgactcatc tcgtgggagc cttcatggca cattgctgct gttctgcagg tcccaataca   4260

attccttccc cctctcagtg ccacggcccc cccattgcta gctacacaat ttgatatcat   4320

attccctttt caactccaaa ggagatgata agaagctatc aaataatgct ttaaaaaagc   4380

aacttgagtt tcttaaaaga aaggaaatga atacatgctg cataattaca tttaaaatgt   4440

aagccatgtt attataagcc gcactgagat gaagatttgt tagcaaacca gtttcaagca   4500

cactcacagt gaagtaaaat catgttttta gcatctgacc attgggtaat attattcttt   4560

gttatcaaaa gagaaatatc acccaagtat agtatactta gacctcctag aggaaacact   4620

ccagtcctaa gcttggtgtc tgaaaagaaa aacaaaaata aagattatgg atttaggtca   4680

gggagacaga gtgatattct gaagactgtg tttactccct catcatcggc caaccaagat   4740

ggagttctgc atcctgcaca tatcagacat ttcagtccaa tttcaccaaa gcatcagtga   4800

tgttctagaa gcatcccagc agatggagga tcctaatgta tttgttctgg gtatttccca   4860

aggcccagcc tgactggagt gtgtgtacca acaggatgaa tccaatcaag ctacgccccc   4920

attttggttt cggattggcc actcttgcat gtgctagtag attgtggacc aggaccagct   4980

gagcaaacac agttgcagag tagcctccta tgttgctaag aagctcctgc tacccaggtg   5040

ctttgaacaa ttgagtgctc cctctggtta agtagagatg gcaccaccgg agtttttctt   5100

ggatgtgagg ctcaatcctt tacggcagct attataacaa agtgaaggtt ttctccctgg   5160

gaaatgcagc ttttctctgt ctttactaat tctgccagcc tgtgagagta accaccgtag   5220

ctgggcttct tctcagatta attgtcatgc caggtctcct tcctggggag ctgtgatgct   5280

gctctgaggt tgattgctga ggttgtagtg ggtttttgtt tgtttttgtt tagtttttct   5340

tgattgttct tctttctctt gaatggcaag agaagaaaca ctttctctaa cccacggcca   5400

ggaaggaaat ggggagagag ctacttctta gttcaacctg gttgccacat aaaggaatct   5460

ctctccttgg actcagcccc taactggaag caagagccac tgccctctga gactgagaga   5520

gcagcccgag gaggagatga atccattctg ccctttgttt gggtttgctt cctgtcagtg   5580

agagaatgct gaggcagttc ctgttatgtg aaactttcat ttttaaaacc aggacagtcc   5640

taaacagact ggaatgagtt ggtcaatccc agttggtata ggcccaatga tttttgctag   5700

taagatagga ttgtcttcct cacccaaaat gccttcaagt gccctaaaat gggtatttta   5760

aaataagaat aaataatgta gatttagtag aaaacctgga aaacataaga aacaaagatg   5820

aaacgaaaag tcccatgtaa ttccaccagt tagagttaac cactgatatc gtttggatat   5880

atggctttct agtcttgtgg atatcctttt aatctcttgt aatataaagt ctgaccatat   5940

gtgtccttgc atttgtttgt actggactct gttaatattt ctatagtaat ggctcacttt   6000

ggggagattg tgctgcacag tgtgtaggaa gcacattggg tgtattattc ccagttttgt   6060

attttgtatt tccttggaga tgtgcagggg ttaagagcgg gggtctggcc atagctggcc   6120

acgtcagact ctcatatggt aagtatcaca gagcacatga ggcctgtgtt atgcgctgga   6180

aagactcagg aaatgagagg ctctcttgtt ctgacaaggc aggctgagag ctctcattta   6240

gggtcatcac tccagataac tccaaatgca gtttattgct caactgaagc agatgatcac   6300

tttttgcctc caagttcttc accctagcta gctcctttca aagagccgag tatgctggat   6360

cttaaagggc caaactagtt acatctcata catttcctga tgtttaggga tgccttcact   6420

tccatcaagg ataccttggc tgtgcaagga cctctgatag ctggagtctc cttttggtca   6480

ctcccagctt tgcttaaact tgatggagtt tgctgtccag tgatccccgg atctttcatc   6540

atgaaagcct tccttcctct cctgatgtct caggcctcta gacctagact ggggttctgg   6600

caaggaggcc tctatcaata gtatgacatc caataatatg ttagtgttga tattttgcac   6660

agtaatatta agtttaagag attataaaaa tgagttcaaa tgaataagtt cctgtgatgt   6720

aagagattag atatgtgtga tttcagaacc aaagccaggg gggaatccca gaaagaaaac   6780

aataatataa tcctagtttc tatatattat ttttattcat tactgtatat gggtagagat   6840

caatattctt tcttatgctg ttactattaa ttaacacatt ttttaaccat gccattgaac   6900

ttttgggtgc attaaagtgg aacccaagct cctcattaga taataatggc atttggactg   6960

agtgccatat tcctaaattt ccaataaagt ggttgatata gagaggacag gataaagccc   7020

tatagtgtgc agttatatca aaacagctag tctccacttt agggaatgcc tttactagag   7080

attacatgaa atgtctgctt ataaaataag cagagatggc accactaagc agccacctga   7140

attgttttcc tacaggaatg attacttttc agatccattt atgttttcat gctcaatact   7200

tactcccctt ccctgcaaca cccaaagagt ttacttttgc aagtcatttg gtcttcagtc   7260

tactactgag gaatagagag gcactaactg ctttacccag gatcagaact catgttctta   7320

ccttctatta atagagtact tgagccagat ggactaactg gtctcacatt ttctctatct   7380

tggttttact tccataaaca tcaatatctt tacccacatg atttttccat cctcccattt   7440

ttttccatat gtattagggt tcaggaacta tgatgctaat gatcacattt cttcctagtt   7500

cctaatttca ttagtgccat ttcctgatat ctacagaaac aattatcaat acatgtagct   7560

gcttgagcct tatttagaag gctagccttt cttttccaag tgctgtcaga atgtatacat   7620

ttagtctgtc tttttccctt ttaggagtct ttgttctggg ttgatggcaa aattcctctt   7680

tttacatgtg agatttttga tttcactgaa ttctacctag atttttatgg acattggatt   7740

ttaaagagga aaacactcat tttcttagta agatattggt gatacatagc tatgccattg   7800

atttccatac tcctgagctt tggggaggga gacagtggcc aagtagcagg cagaataaga   7860

tcatcactca tgtcctgaat caatcacact ttccttctcg gattgtgtat atgctctgcc   7920

acttcctaca tattacatcc tgagttttta agtaaagtgg atcttagcca gatttgagtc   7980

taatggctga ttcatcggca tagttcttgg cgttaacatc tcagtgtcct ctttagttct   8040

ctttgaggat tcatgtcatt gagggccttt gtgcctccac ttgtctcagt atgaggaaga   8100

actttggtgt gagggcggag ctatgtgaag ggttgctggg ttgggggatt agttcatatg   8160

gtccccatgc catctattta cttttggaga ga                                 8192


<210>  2374
<211>  553
<212>  PRT
<213>  Homosapiens

<400>  2374

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Asp Phe Ser Trp Phe Gly Phe Gly Lys Val Lys Ser Arg Gln Gly 
465                 470                 475                 480 


Val Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
                485                 490                 495     


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
            500                 505                 510         


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
        515                 520                 525             


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
    530                 535                 540                 


Trp Pro Arg Gly Ser Pro Lys Thr Ala 
545                 550             


<210>  2375
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  2375
aagacggatt ctcagacaag gcttgcaaat gccccgcagc catcatttaa ctgcacccgc     60

agaatagtta cggtttgtca cccgaccctc ccggatcgcc taatttgtcc ctagtgagac    120

cccgaggctc tgcccgcgcc tggcttcttc gtagctggat gcatatcgtg ctccgggcag    180

cgcgggcgca gggcacgcgt tcgcgcacac cctagcacac atgaacacgc gcaagagctg    240

aaccaagcac ggtttccatt tcaaaaaggg agacagcctc taccgcgatt gtagaagaga    300

ctgtggtgtg aattagggac cgggaggcgt cgaacggagg aacggttcat cttagagact    360

aattttctgg agtttctgcc cctgctctgc gtcagccctc acgtcacttc gccagcagta    420

gcagaggcgg cggcggcggc tcccggaatt gggttggagc aggagcctcg ctggctgctt    480

cgctcgcgct ctacgcgctc agtccccggc ggtagcagga gcctggaccc aggcgccgcc    540

ggcgggcgtg aggcgccgga gcccggcctc gaggtgcata ccggaccccc attcgcatct    600

aacaaggaat ctgcgcccca gagagtcccg ggagcgccgc cggtcggtgc ccggcgcgcc    660

gggccatgca gcgacggccg ccgcggagct ccgagcagcg gtagcgcccc cctgtaaagc    720

ggttcgctat gccggggcca ctgtgaaccc tgccgcctgc cggaacactc ttcgctccgg    780

accagctcag cctctgataa gctggactcg gcacgcccgc aacaagcacc gaggagttaa    840

gagagccgca agcgcaggga aggcctcccc gcacgggtgg gggaaagcgg ccggtgcagc    900

gcggggacag gcactcgggc tggcactggc tgctagggat gtcgtcctgg ataaggtggc    960

atggacccgc catggcgcgg ctctggggct tctgctggct ggttgtgggc ttctggaggg   1020

ccgctttcgc ctgtcccacg tcctgcaaat gcagtgcctc tcggatctgg tgcagcgacc   1080

cttctcctgg catcgtggca tttccgagat tggagcctaa cagtgtagat cctgagaaca   1140

tcaccgaaat tttcatcgca aaccagaaaa ggttagaaat catcaacgaa gatgatgttg   1200

aagcttatgt gggactgaga aatctgacaa ttgtggattc tggattaaaa tttgtggctc   1260

ataaagcatt tctgaaaaac agcaacctgc agcacatcaa ttttacccga aacaaactga   1320

cgagtttgtc taggaaacat ttccgtcacc ttgacttgtc tgaactgatc ctggtgggca   1380

atccatttac atgctcctgt gacattatgt ggatcaagac tctccaagag gctaaatcca   1440

gtccagacac tcaggatttg tactgcctga atgaaagcag caagaatatt cccctggcaa   1500

acctgcagat acccaattgt ggtttgccat ctgcaaatct ggccgcacct aacctcactg   1560

tggaggaagg aaagtctatc acattatcct gtagtgtggc aggtgatccg gttcctaata   1620

tgtattggga tgttggtaac ctggtttcca aacatatgaa tgaaacaagc cacacacagg   1680

gctccttaag gataactaac atttcatccg atgacagtgg gaagcagatc tcttgtgtgg   1740

cggaaaatct tgtaggagaa gatcaagatt ctgtcaacct cactgtgcat tttgcaccaa   1800

ctatcacatt tctcgaatct ccaacctcag accaccactg gtgcattcca ttcactgtga   1860

aaggcaaccc caaaccagcg cttcagtggt tctataacgg ggcaatattg aatgagtcca   1920

aatacatctg tactaaaata catgttacca atcacacgga gtaccacggc tgcctccagc   1980

tggataatcc cactcacatg aacaatgggg actacactct aatagccaag aatgagtatg   2040

ggaaggatga gaaacagatt tctgctcact tcatgggctg gcctggaatt gacgatggtg   2100

caaacccaaa ttatcctgat gtaatttatg aagattatgg aactgcagcg aatgacatcg   2160

gggacaccac gaacagaagt aatgaaatcc cttccacaga cgtcactgat aaaaccggtc   2220

gggaacatct ctcggtctat gctgtggtgg tgattgcgtc tgtggtggga ttttgccttt   2280

tggtaatgct gtttctgctt aagttggcaa gacactccaa gtttggcatg aaaggcccag   2340

cctccgttat cagcaatgat gatgactctg ccagcccact ccatcacatc tccaatggga   2400

gtaacactcc atcttcttcg gaaggtggcc cagatgctgt cattattgga atgaccaaga   2460

tccctgtcat tgaaaatccc cagtactttg gcatcaccaa cagtcagctc aagccagaca   2520

catggcccag aggttccccc aagaccgcct gataataatt tggtatttgg aggctcctgt   2580

gtcactgcag gaactaaagg aggctaaatc catgcctgat ggaggagaag agttctatgg   2640

ttatctgcaa attctggcca gacaacatct tgacgtcact ccttagcttc cataacctag   2700

ccaagcaaga agttgccttt ccaagacaaa gcagtgtgct ctaatgacta acccctcaaa   2760

gtactatgcc actttaacta tagacccatc tcctcgatca atcaggatgg caagatggag   2820

ctgaggagct cagcaacatc aagtctggag ttggtcttta actcaactag ctcgtttaga   2880

cgtgtctgaa caccacatca cctgacagca cggggtggtt tcccagtaaa atttacaaac   2940

tcagctcaag ggcagctgtg ttgctttcct ttccttgact gctgagaaac tttttgacag   3000

ggaacaatgg aaacacacct tctgagctga aacaaacaaa cagaaacaaa acatactaac   3060

cagcaaaatc cccaaatcat caatcttggg ttctcttgaa gggcaggagt gtgttttatc   3120

ttctcccgtc ggagcaaaca ctatagatgt cctccctaaa attctgtctt ccctagagca   3180

gccttgtaaa ttagctaggg tcctagggtt gaggcctaaa tcaacttaaa attgtctcta   3240

aatatgtacc tggatgtgtt tgtacttgca gagcatgccc tcttcatgtg cctagggcta   3300

gtaactccct gtggcagagg catgtaaagt attctgactt tttttttttc aacttaattc   3360

catttccaat gaaatggatt tttaaaaatt ttctccagag tgtgccatac ttctccagct   3420

attatagtta atgtgtgtgt atccttgtgt atatgtgtgt ttgtgtgtgc atatgtgttt   3480

tcctagtggt tacatgctta ctaggcaatt atgtaaataa gcacagattc ataggccagc   3540

taggcctgag gaaagaagac attataaagg gagggagtat tttaacatta gctaaagcta   3600

tcacacaagg cacccattct gctcccctca acagccacag cccacttcgt ccttgtctta   3660

ccaataaggg gaaaggctgg aggtgatatt tttcacagaa ccgcagaggt tttgaacata   3720

tttgcaacat tactttgagt acacatgagc aaaaattctg aattacatcc aggaccccag   3780

aagctcatta gatcaaagag tgcggggccc ctcagagtta ccagagatta tctgcagact   3840

tcagtgcaat cgaatgacca tggtccattt tgatggtcag aggtaggact gaaaaacggg   3900

tagaaacaat tgctttagcg cttccttctg tactttgcct attaatgttt tgtctttcaa   3960

aaatatattt tctcctaatt gtttaattgg ccaaataatg gctgctttgg gagttgtttg   4020

tatgccttgg aaggccatgg cctgcacttt aaaaataagc taagtccatt ctgcccagca   4080

cgagcattag gacagagaat gcacttattt taggatcctt aaaaattgct tcttttatgg   4140

cacactgggt tgacgactca tctcgtggga gccttcatgg cacattgctg ctgttctgca   4200

ggtcccaata caattccttc cccctctcag tgccacggcc cccccattgc tagctacaca   4260

atttgatatc atattccctt ttcaactcca aaggagatga taagaagcta tcaaataatg   4320

ctttaaaaaa gcaacttgag tttcttaaaa gaaaggaaat gaatacatgc tgcataatta   4380

catttaaaat gtaagccatg ttattataag ccgcactgag atgaagattt gttagcaaac   4440

cagtttcaag cacactcaca gtgaagtaaa atcatgtttt tagcatctga ccattgggta   4500

atattattct ttgttatcaa aagagaaata tcacccaagt atagtatact tagacctcct   4560

agaggaaaca ctccagtcct aagcttggtg tctgaaaaga aaaacaaaaa taaagattat   4620

ggatttaggt cagggagaca gagtgatatt ctgaagactg tgtttactcc ctcatcatcg   4680

gccaaccaag atggagttct gcatcctgca catatcagac atttcagtcc aatttcacca   4740

aagcatcagt gatgttctag aagcatccca gcagatggag gatcctaatg tatttgttct   4800

gggtatttcc caaggcccag cctgactgga gtgtgtgtac caacaggatg aatccaatca   4860

agctacgccc ccattttggt ttcggattgg ccactcttgc atgtgctagt agattgtgga   4920

ccaggaccag ctgagcaaac acagttgcag agtagcctcc tatgttgcta agaagctcct   4980

gctacccagg tgctttgaac aattgagtgc tccctctggt taagtagaga tggcaccacc   5040

ggagtttttc ttggatgtga ggctcaatcc tttacggcag ctattataac aaagtgaagg   5100

ttttctccct gggaaatgca gcttttctct gtctttacta attctgccag cctgtgagag   5160

taaccaccgt agctgggctt cttctcagat taattgtcat gccaggtctc cttcctgggg   5220

agctgtgatg ctgctctgag gttgattgct gaggttgtag tgggtttttg tttgtttttg   5280

tttagttttt cttgattgtt cttctttctc ttgaatggca agagaagaaa cactttctct   5340

aacccacggc caggaaggaa atggggagag agctacttct tagttcaacc tggttgccac   5400

ataaaggaat ctctctcctt ggactcagcc cctaactgga agcaagagcc actgccctct   5460

gagactgaga gagcagcccg aggaggagat gaatccattc tgccctttgt ttgggtttgc   5520

ttcctgtcag tgagagaatg ctgaggcagt tcctgttatg tgaaactttc atttttaaaa   5580

ccaggacagt cctaaacaga ctggaatgag ttggtcaatc ccagttggta taggcccaat   5640

gatttttgct agtaagatag gattgtcttc ctcacccaaa atgccttcaa gtgccctaaa   5700

atgggtattt taaaataaga ataaataatg tagatttagt agaaaacctg gaaaacataa   5760

gaaacaaaga tgaaacgaaa agtcccatgt aattccacca gttagagtta accactgata   5820

tcgtttggat atatggcttt ctagtcttgt ggatatcctt ttaatctctt gtaatataaa   5880

gtctgaccat atgtgtcctt gcatttgttt gtactggact ctgttaatat ttctatagta   5940

atggctcact ttggggagat tgtgctgcac agtgtgtagg aagcacattg ggtgtattat   6000

tcccagtttt gtattttgta tttccttgga gatgtgcagg ggttaagagc gggggtctgg   6060

ccatagctgg ccacgtcaga ctctcatatg gtaagtatca cagagcacat gaggcctgtg   6120

ttatgcgctg gaaagactca ggaaatgaga ggctctcttg ttctgacaag gcaggctgag   6180

agctctcatt tagggtcatc actccagata actccaaatg cagtttattg ctcaactgaa   6240

gcagatgatc actttttgcc tccaagttct tcaccctagc tagctccttt caaagagccg   6300

agtatgctgg atcttaaagg gccaaactag ttacatctca tacatttcct gatgtttagg   6360

gatgccttca cttccatcaa ggataccttg gctgtgcaag gacctctgat agctggagtc   6420

tccttttggt cactcccagc tttgcttaaa cttgatggag tttgctgtcc agtgatcccc   6480

ggatctttca tcatgaaagc cttccttcct ctcctgatgt ctcaggcctc tagacctaga   6540

ctggggttct ggcaaggagg cctctatcaa tagtatgaca tccaataata tgttagtgtt   6600

gatattttgc acagtaatat taagtttaag agattataaa aatgagttca aatgaataag   6660

ttcctgtgat gtaagagatt agatatgtgt gatttcagaa ccaaagccag gggggaatcc   6720

cagaaagaaa acaataatat aatcctagtt tctatatatt atttttattc attactgtat   6780

atgggtagag atcaatattc tttcttatgc tgttactatt aattaacaca ttttttaacc   6840

atgccattga acttttgggt gcattaaagt ggaacccaag ctcctcatta gataataatg   6900

gcatttggac tgagtgccat attcctaaat ttccaataaa gtggttgata tagagaggac   6960

aggataaagc cctatagtgt gcagttatat caaaacagct agtctccact ttagggaatg   7020

cctttactag agattacatg aaatgtctgc ttataaaata agcagagatg gcaccactaa   7080

gcagccacct gaattgtttt cctacaggaa tgattacttt tcagatccat ttatgttttc   7140

atgctcaata cttactcccc ttccctgcaa cacccaaaga gtttactttt gcaagtcatt   7200

tggtcttcag tctactactg aggaatagag aggcactaac tgctttaccc aggatcagaa   7260

ctcatgttct taccttctat taatagagta cttgagccag atggactaac tggtctcaca   7320

ttttctctat cttggtttta cttccataaa catcaatatc tttacccaca tgatttttcc   7380

atcctcccat ttttttccat atgtattagg gttcaggaac tatgatgcta atgatcacat   7440

ttcttcctag ttcctaattt cattagtgcc atttcctgat atctacagaa acaattatca   7500

atacatgtag ctgcttgagc cttatttaga aggctagcct ttcttttcca agtgctgtca   7560

gaatgtatac atttagtctg tctttttccc ttttaggagt ctttgttctg ggttgatggc   7620

aaaattcctc tttttacatg tgagattttt gatttcactg aattctacct agatttttat   7680

ggacattgga ttttaaagag gaaaacactc attttcttag taagatattg gtgatacata   7740

gctatgccat tgatttccat actcctgagc tttggggagg gagacagtgg ccaagtagca   7800

ggcagaataa gatcatcact catgtcctga atcaatcaca ctttccttct cggattgtgt   7860

atatgctctg ccacttccta catattacat cctgagtttt taagtaaagt ggatcttagc   7920

cagatttgag tctaatggct gattcatcgg catagttctt ggcgttaaca tctcagtgtc   7980

ctctttagtt ctctttgagg attcatgtca ttgagggcct ttgtgcctcc acttgtctca   8040

gtatgaggaa gaactttggt gtgagggcgg agctatgtga agggttgctg ggttggggga   8100

ttagttcata tggtccccat gccatctatt tacttttgga gagaggggac tttgagtggg   8160

tgggtatgga tagatgttcc tcaaggaaac cc                                 8192


<210>  2376
<211>  537
<212>  PRT
<213>  Homosapiens

<400>  2376

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
                485                 490                 495     


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
        515                 520                 525             


Trp Pro Arg Gly Ser Pro Lys Thr Ala 
    530                 535         


<210>  2377
<211>  5608
<212>  DNA
<213>  Homosapiens

<400>  2377
aagacggatt ctcagacaag gcttgcaaat gccccgcagc catcatttaa ctgcacccgc     60

agaatagtta cggtttgtca cccgaccctc ccggatcgcc taatttgtcc ctagtgagac    120

cccgaggctc tgcccgcgcc tggcttcttc gtagctggat gcatatcgtg ctccgggcag    180

cgcgggcgca gggcacgcgt tcgcgcacac cctagcacac atgaacacgc gcaagagctg    240

aaccaagcac ggtttccatt tcaaaaaggg agacagcctc taccgcgatt gtagaagaga    300

ctgtggtgtg aattagggac cgggaggcgt cgaacggagg aacggttcat cttagagact    360

aattttctgg agtttctgcc cctgctctgc gtcagccctc acgtcacttc gccagcagta    420

gcagaggcgg cggcggcggc tcccggaatt gggttggagc aggagcctcg ctggctgctt    480

cgctcgcgct ctacgcgctc agtccccggc ggtagcagga gcctggaccc aggcgccgcc    540

ggcgggcgtg aggcgccgga gcccggcctc gaggtgcata ccggaccccc attcgcatct    600

aacaaggaat ctgcgcccca gagagtcccg ggagcgccgc cggtcggtgc ccggcgcgcc    660

gggccatgca gcgacggccg ccgcggagct ccgagcagcg gtagcgcccc cctgtaaagc    720

ggttcgctat gccggggcca ctgtgaaccc tgccgcctgc cggaacactc ttcgctccgg    780

accagctcag cctctgataa gctggactcg gcacgcccgc aacaagcacc gaggagttaa    840

gagagccgca agcgcaggga aggcctcccc gcacgggtgg gggaaagcgg ccggtgcagc    900

gcggggacag gcactcgggc tggcactggc tgctagggat gtcgtcctgg ataaggtggc    960

atggacccgc catggcgcgg ctctggggct tctgctggct ggttgtgggc ttctggaggg   1020

ccgctttcgc ctgtcccacg tcctgcaaat gcagtgcctc tcggatctgg tgcagcgacc   1080

cttctcctgg catcgtggca tttccgagat tggagcctaa cagtgtagat cctgagaaca   1140

tcaccgaaat tttcatcgca aaccagaaaa ggttagaaat catcaacgaa gatgatgttg   1200

aagcttatgt gggactgaga aatctgacaa ttgtggattc tggattaaaa tttgtggctc   1260

ataaagcatt tctgaaaaac agcaacctgc agcacatcaa ttttacccga aacaaactga   1320

cgagtttgtc taggaaacat ttccgtcacc ttgacttgtc tgaactgatc ctggtgggca   1380

atccatttac atgctcctgt gacattatgt ggatcaagac tctccaagag gctaaatcca   1440

gtccagacac tcaggatttg tactgcctga atgaaagcag caagaatatt cccctggcaa   1500

acctgcagat acccaattgt ggtttgccat ctgcaaatct ggccgcacct aacctcactg   1560

tggaggaagg aaagtctatc acattatcct gtagtgtggc aggtgatccg gttcctaata   1620

tgtattggga tgttggtaac ctggtttcca aacatatgaa tgaaacaagc cacacacagg   1680

gctccttaag gataactaac atttcatccg atgacagtgg gaagcagatc tcttgtgtgg   1740

cggaaaatct tgtaggagaa gatcaagatt ctgtcaacct cactgtgcat tttgcaccaa   1800

ctatcacatt tctcgaatct ccaacctcag accaccactg gtgcattcca ttcactgtga   1860

aaggcaaccc caaaccagcg cttcagtggt tctataacgg ggcaatattg aatgagtcca   1920

aatacatctg tactaaaata catgttacca atcacacgga gtaccacggc tgcctccagc   1980

tggataatcc cactcacatg aacaatgggg actacactct aatagccaag aatgagtatg   2040

ggaaggatga gaaacagatt tctgctcact tcatgggctg gcctggaatt gacgatggtg   2100

caaacccaaa ttatcctgat gtaatttatg aagattatgg aactgcagcg aatgacatcg   2160

gggacaccac gaacagaagt aatgaaatcc cttccacaga cgtcactgat aaaaccggtc   2220

gggaacatct ctcggtctat gctgtggtgg tgattgcgtc tgtggtggga ttttgccttt   2280

tggtaatgct gtttctgctt aagttggcaa gacactccaa gtttggcatg aaagatttct   2340

catggtttgg atttgggaaa gtaaaatcaa gacaaggtgt tggcccagcc tccgttatca   2400

gcaatgatga tgactctgcc agcccactcc atcacatctc caatgggagt aacactccat   2460

cttcttcgga aggtggccca gatgctgtca ttattggaat gaccaagatc cctgtcattg   2520

aaaatcccca gtactttggc atcaccaaca gtcagctcaa gccagacaca tttgttcagc   2580

acatcaagcg acataacatt gttctgaaaa gggagctagg cgaaggagcc tttggaaaag   2640

tgttcctagc tgaatgctat aacctctgtc ctgagcagga caagatcttg gtggcagtga   2700

agaccctgaa ggatgccagt gacaatgcac gcaaggactt ccaccgtgag gccgagctcc   2760

tgaccaacct ccagcatgag cacatcgtca agttctatgg cgtctgcgtg gagggcgacc   2820

ccctcatcat ggtctttgag tacatgaagc atggggacct caacaagttc ctcagggcac   2880

acggccctga tgccgtgctg atggctgagg gcaacccgcc cacggaactg acgcagtcgc   2940

agatgctgca tatagcccag cagatcgccg cgggcatggt ctacctggcg tcccagcact   3000

tcgtgcaccg cgatttggcc accaggaact gcctggtcgg ggagaacttg ctggtgaaaa   3060

tcggggactt tgggatgtcc cgggacgtgt acagcactga ctactacagg gtcggtggcc   3120

acacaatgct gcccattcgc tggatgcctc cagagagcat catgtacagg aaattcacga   3180

cggaaagcga cgtctggagc ctgggggtcg tgttgtggga gattttcacc tatggcaaac   3240

agccctggta ccagctgtca aacaatgagg tgatagagtg tatcactcag ggccgagtcc   3300

tgcagcgacc ccgcacgtgc ccccaggagg tgtatgagct gatgctgggg tgctggcagc   3360

gagagcccca catgaggaag aacatcaagg gcatccatac cctccttcag aacttggcca   3420

aggcatctcc ggtctacctg gacattctag gctagggccc ttttccccag accgatcctt   3480

cccaacgtac tcctcagacg ggctgagagg atgaacatct tttaactgcc gctggaggcc   3540

accaagctgc tctccttcac tctgacagta ttaacatcaa agactccgag aagctctcga   3600

gggaagcagt gtgtacttct tcatccatag acacagtatt gacttctttt tggcattatc   3660

tctttctctc tttccatctc ccttggttgt tcctttttct ttttttaaat tttctttttc   3720

tttttttttt cgtcttccct gcttcacgat tcttaccctt tcttttgaat caatctggct   3780

tctgcattac tattaactct gcatagacaa aggccttaac aaacgtaatt tgttatatca   3840

gcagacactc cagtttgccc accacaacta acaatgcctt gttgtattcc tgcctttgat   3900

gtggatgaaa aaaagggaaa acaaatattt cacttaaact ttgtcacttc tgctgtacag   3960

atatcgagag tttctatgga ttcacttcta tttatttatt attattactg ttcttattgt   4020

ttttggatgg cttaagcctg tgtataaaaa agaaaacttg tgttcaatct gtgaagcctt   4080

tatctatggg agattaaaac cagagagaaa gaagatttat tatgaaccgc aatatgggag   4140

gaacaaagac aaccactggg atcagctggt gtcagtccct acttaggaaa tactcagcaa   4200

ctgttagctg ggaagaatgt attcggcacc ttcccctgag gacctttctg aggagtaaaa   4260

agactactgg cctctgtgcc atggatgatt cttttcccat caccagaaat gatagcgtgc   4320

agtagagagc aaagatggct tccgtgagac acaagatggc gcatagtgtg ctcggacaca   4380

gttttgtctt cgtaggttgt gatgatagca ctggtttgtt tctcaagcgc tatccacaga   4440

acctttgtca acttcagttg aaaagaggtg gattcatgtc cagagctcat ttcggggtca   4500

ggtgggaaag ccaagaactt ggaaaagata agacaagcta taaattcgga ggcaagtttc   4560

ttttacaatg aacttttcag atctcacttc cctccgaccc ctaacttcca tgcccacccg   4620

tccttttaac tgtgcaagca aaattgtgca tggtcttcgt cgattaatac cttgtgtgca   4680

gacactactg ctccagacgt cgtttccctg ataggtagag cagatccata aaaaggtatg   4740

acttatacaa ttaggggaag ctaatggagt ttattagctg agtatcaatg tctctgcgtt   4800

gtacggtggt gatgggtttt aatgaatatg gaccctgaag cctggaaatc ctcatccacg   4860

tcgaacccac aggactgtgg gaagggcaga atcaatccct aagggaaagg aaacctcacc   4920

ctgagggcat cacatgcact catgttcagt gtacacaggt caagtccctt gctctgggct   4980

ctagttggga gagtggtttc attccaagtg tactccattg tcagtatgct gtttttgttt   5040

ccttcactcc attcaaaaag tcaaaataca aaatttggca cagcatgcca acgggaggct   5100

gtgcccagac caagcactgg aagtgtgctt ctaggcatag tcattggttt tgcaaaaaga   5160

gggctcaaat ttaaatagaa atttacagct atttgaatgg tcagatatac caagaaagaa   5220

aaatatttct gttcctcaag aaaacttgct accctctgtg aggggaattt tgctaaactt   5280

gacatcttta taacatgagc cagattgaaa gggagtgatt ttcattcatc ttaggtcatg   5340

ttatttcata tttgtttctg aaggtgcgat agctctgttt taggttttgc ttgcgcctgt   5400

taattactgg aacaccttat ttttcattaa aggctttgaa agccaattct caaaaattca   5460

aaagtgcaaa ttaacagaac aaaaggaaat ccagtagcaa ctgcagtcaa gcgagggagt   5520

tgacaagata aaccttacgt ccattcaagt tatatgctgg cctatgagag atgagagttg   5580

ggtcgtttgt tctctttgtt gatgattt                                      5608


<210>  2378
<211>  838
<212>  PRT
<213>  Homosapiens

<400>  2378

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Asp Phe Ser Trp Phe Gly Phe Gly Lys Val Lys Ser Arg Gln Gly 
465                 470                 475                 480 


Val Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
                485                 490                 495     


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
            500                 505                 510         


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
        515                 520                 525             


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
    530                 535                 540                 


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
545                 550                 555                 560 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
                565                 570                 575     


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
            580                 585                 590         


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
        595                 600                 605             


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
    610                 615                 620                 


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
625                 630                 635                 640 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
                645                 650                 655     


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
            660                 665                 670         


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
        675                 680                 685             


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
    690                 695                 700                 


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
705                 710                 715                 720 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
                725                 730                 735     


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
            740                 745                 750         


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
        755                 760                 765             


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
    770                 775                 780                 


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
785                 790                 795                 800 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
                805                 810                 815     


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
            820                 825                 830         


Tyr Leu Asp Ile Leu Gly 
        835             


<210>  2379
<211>  5154
<212>  DNA
<213>  Homosapiens

<400>  2379
gttcgcagct caggaaggag ggagccccag gaacaggagt cccaccgaag aactgctctc     60

tgacagaaca gagacctcct caccagggct tccaaacaga tgcagaagaa cccagaaagg    120

agcaggtctt gatttgccca accagcggca cttcttcatc cccttgccca gagagcacca    180

gacttggtga tgtcgccaca tccagaagcc atcacagatt gtgtgacact gaacactgtg    240

ggccaacttg cagaaggtgg ttatccttta cggttctcca cactctttca ggagcagcag    300

aaaatgaaca tatctcaggc atcagtgtca ttcaaggacg tgactataga attcacccag    360

gaggagtggc agcaaatggc ccctgttcag aagaatctgt acagagatgt gatgctggag    420

aactacagca acctcgtctc agtggggtac tgctgtttca aaccagaggt gatcttcaag    480

ttggagcaag gagaggagcc ttggttctca gaggaggaat tctcaaacca gagtcaccca    540

aaagattaca gaggtgatga cctgatcaag cagaacaaga aaatcaaaga caaacacttg    600

gagcaagcaa tatgtatcaa taataaaaca ttgactacag aggaagagaa agttttgggg    660

aaaccattta ctctgcatgt agctgctgtt gcttcaacaa aaatgtcctg caaatgcaac    720

tcatgggaag tgaatttgca aagtatttct gaatttatca ttaataatag aaactattca    780

acaaagaaaa taggttgcgg taatgtatgt gagaattcac ctttcaaaat taactttgag    840

aaaactcaga ctggagagaa attttatgaa cataataaaa acatgaaagc tctcaattat    900

aatgaaaatc ttcccaagca tccaaagttt caaactttgg agcaagcttt tgaatgtaat    960

aaaattggaa aagcctttaa tgataaggct aactgtgtta aacataacag ttctcacaca   1020

ggagaaacat cctctaaaga tgatgaattt aggaaaaatt gtgataagaa aactctcttt   1080

gaccacagga gaactggcac agggaagaaa cacctgcatc ttaatcaatg tgggaaatcc   1140

tttgagaagt caactgtgga ggaatataat aaacttaata tgggtataaa acattatgaa   1200

ttaaatccaa gtggaaataa tttcaacaga aaggcacacc tcactgatcc tcaaacagct   1260

gtcatagaag agaacccatt ggtaagtaat gacagaacac agacttgggt taaatcctct   1320

gaatatcatg aaaataagaa atcctaccag acgtcggttc acagagttcg ccgaagaagt   1380

cactcaatga tgaaacccta taaatgtaat gaatgtggga aatccttctg tcagaaagga   1440

catctcattc aacatcagag aactcacaca ggagagaaac catttgaatg tagtgaatgt   1500

ggaaaaactt tctcccagaa gtcacacctc agtactcatc agagaattca tacagcagaa   1560

aaaccctata aatgtaatga atgtggaaaa acatttgtcc agaagtcaac cctcagggga   1620

catcaaagaa ttcacacagg agaaaaaccc tatgaatgta gtgaatgtgg gaaaactttt   1680

gttcagaagt ccaccctcag agatcatcac agaattcaca caggggagaa atcctttcaa   1740

tgcaatcaat gtggaaaaac atttggccag aagtcaaacc tcagaataca tcagagaact   1800

cacactgggg agaaaactta ccagtgtaat gaatgtgaaa aatccttctg gcgaaaagat   1860

catctcattc aacatcagaa aactcacacg ggagagaaac cattcaaatg taacgaatgt   1920

gggaaaactt ttgcccggac atcaaccctc agagtgcatc aaagaattca cactggggag   1980

aaaccattta aatgtaatga atgtgggaag aaatttgtcc ggaaagcaat ccttagtgat   2040

catcagagaa ttcacacagg ggagaaaccc tttcagtgta ataaatgtgg gaaaactttt   2100

ggccagaaat caaacctcag aatacatcaa aggactcaca gtggggagaa atcttatgaa   2160

tgcaatgaat atgggaaatt atgtaagaag tctaccctaa gcttatacca gaaaattcag   2220

ggagagggga atccctattg atgtaataac tagaaaatcc ttttgacaaa aggaataccc   2280

catttgatat cagagataca caaaaaacca attgagggta gtgaatgtaa gaagacagtc   2340

ccagaagtaa accctcactg tgaatcagag aattcacata ggaaagaaac cagatgaaga   2400

tgaatgcagg aagaattgtg tccaaaatgc aaccttcaga gtgtatcaaa gaattcagac   2460

aggcttctgt tttcagagta ctatggatag gcctgaatga agtcataccc tattagatag   2520

ctcccacaca tcacacaggc tggtaatctc ttcaccagca ccaatttcat tttactccag   2580

gcacatagtc cagatttccc aatctccttt tcatccaggt tggtctttgt gactggctac   2640

taagatgtgg atgtccatga tgtatatcac atcccagtct gaaacataag agacttccct   2700

aataaattac cagggccctg tcacaacaaa atggatatca tttctaggac aagcttggtg   2760

ccgtgcttta atgtggcatg gtacaagata aagaagtctg tgcctgaatg aatacacgca   2820

gcaaaattct cctcttctgt gtctttccca gttgaacatt atgtgagcaa aatttaagct   2880

tatacagtag tcccccctta tctgtatttt cactttacgc aatttccatt aaccatggtc   2940

aactgtactt taaagttatt aaatggatcc agaaataaac aattcctaca ttttaaactg   3000

cacccgattc tgagtagtgg gatgaagtct catgccctcc tgctctccca tgagggttat   3060

tgaatcattc cttagtctag catatccaca gtgtatacac tatctgccag ttagtcactt   3120

acttgacatt ttagttatca gatcacctgt cagggtatga cagtgcttgt attcaagtaa   3180

cccttgtttt actaaataat ggcctgaaat tgcaagagca tttctggcat gttgttgtaa   3240

ttattccatt attagtcctt aatttataaa ttaggcacag caagagatta aactatcata   3300

ggcatgtgta tatgtaggaa aaaaatatag tatatacagg gttcagtata cccgtggttt   3360

caaacatcaa cttggaattc ttggagagca ttccttgtag ttaagcaggg actactgtat   3420

tctgttgagc tttcacatgt ttgagtctat ttgtttctac acataattta gttatcttct   3480

gctaggaagg cagaaagctt ctgtgtaagc caggcttaag tcaatcagag ggcacaaacc   3540

ttattaggag gctagagagt caaggagaac ctcaaatatg atcagagaat tgtggaaaag   3600

acatcctttc aatgtaatga aattgatagt accacctgat acagggcttt gcatgaacct   3660

aaaagtcttt tggctgaatg gtgagcagcc actgtgcagt tcaacgtaag tgtgccttaa   3720

ttgcacagag gtactgcccc cacacctcct gacacctcca tataccccag ctatatctgc   3780

tttaaggagt tttccctggc tccaaaggcc attggcaccc acccaagtat tatgggaaac   3840

ctccagagag gggagggact cagatttata tggctttatt gaatccatgc ccaaggcaac   3900

atcttactag ttcctgtggg ggtacaggac acctagattt agctaatggg gtttggcaat   3960

gggaaggcaa acaaatttaa taactttatg ggtgaggtac tttgggccag tagagtatac   4020

tacagttatg tttacatctg aaagtgtagt agggattaat tcccataagt tatagagaga   4080

attctaattc cctgtaattc gcataagtca tagaattcta atcaggaata attgtatgta   4140

aagatacctc tgaggtccaa cagctctgat cattttgggc ttcaagtctc tctctgtgac   4200

tggtgatttt gtgggttgaa acttctggca aaagggggca gcccttggga gctgggggcc   4260

aggggattga cttggttccc tgacaagggt accaggtcca ccccttctga aaagcagctg   4320

ttagtttact cttgggctct tttacacatt ggatatctct tccttgggta gagggttctg   4380

acctaaaatt ccactttagg agtttgtcgt cttggactca acaactaaca aaatgaaaag   4440

gacccagcaa gcctcacttg tggaatgaaa atggggcatt caggaaagca cctgtcctgg   4500

ccccacagta tgtcagctgt ataggcaata gtagtagctg tctcttagaa gggaaataat   4560

gtatcacctc tttccagaac gaagcaaagt tgctggctta gtagagccct caattcatag   4620

aggttactgt aattgggcct ggctcactga tgctttcgcc aactgaaact actaggatcc   4680

tgtgtgtgtt caaactcagt gccattaaca aacccaaagt gaagcggtca ctcctctcag   4740

tggaaagagc acgaggatgt tctcagctct ggccaatact ccatttcata aaccatgtta   4800

catttttgtt aagccttggc tctggatgtg gcctagatat ttgatattct aattggaaat   4860

tacagattaa aaagcaccct ttctttgtac agtgggggta aaagtcacag ctgcttagta   4920

caaccatctg ggttgctcaa gtagatgccc ataataagag actattttct gataagactg   4980

actggaatca agctgccgac agctttctcc atccagattg tgacggttgc tacctggatc   5040

catcatttta ctggtatggc aaaaaatcac ccatgtgaca ctgggtgaca tggtaaaagt   5100

acatggtact tttacagtac catgtactgt acaaaataaa ggtctcttta tctg         5154


<210>  2380
<211>  683
<212>  PRT
<213>  Homosapiens

<400>  2380

Met Ser Pro His Pro Glu Ala Ile Thr Asp Cys Val Thr Leu Asn Thr 
1               5                   10                  15      


Val Gly Gln Leu Ala Glu Gly Gly Tyr Pro Leu Arg Phe Ser Thr Leu 
            20                  25                  30          


Phe Gln Glu Gln Gln Lys Met Asn Ile Ser Gln Ala Ser Val Ser Phe 
        35                  40                  45              


Lys Asp Val Thr Ile Glu Phe Thr Gln Glu Glu Trp Gln Gln Met Ala 
    50                  55                  60                  


Pro Val Gln Lys Asn Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser 
65                  70                  75                  80  


Asn Leu Val Ser Val Gly Tyr Cys Cys Phe Lys Pro Glu Val Ile Phe 
                85                  90                  95      


Lys Leu Glu Gln Gly Glu Glu Pro Trp Phe Ser Glu Glu Glu Phe Ser 
            100                 105                 110         


Asn Gln Ser His Pro Lys Asp Tyr Arg Gly Asp Asp Leu Ile Lys Gln 
        115                 120                 125             


Asn Lys Lys Ile Lys Asp Lys His Leu Glu Gln Ala Ile Cys Ile Asn 
    130                 135                 140                 


Asn Lys Thr Leu Thr Thr Glu Glu Glu Lys Val Leu Gly Lys Pro Phe 
145                 150                 155                 160 


Thr Leu His Val Ala Ala Val Ala Ser Thr Lys Met Ser Cys Lys Cys 
                165                 170                 175     


Asn Ser Trp Glu Val Asn Leu Gln Ser Ile Ser Glu Phe Ile Ile Asn 
            180                 185                 190         


Asn Arg Asn Tyr Ser Thr Lys Lys Ile Gly Cys Gly Asn Val Cys Glu 
        195                 200                 205             


Asn Ser Pro Phe Lys Ile Asn Phe Glu Lys Thr Gln Thr Gly Glu Lys 
    210                 215                 220                 


Phe Tyr Glu His Asn Lys Asn Met Lys Ala Leu Asn Tyr Asn Glu Asn 
225                 230                 235                 240 


Leu Pro Lys His Pro Lys Phe Gln Thr Leu Glu Gln Ala Phe Glu Cys 
                245                 250                 255     


Asn Lys Ile Gly Lys Ala Phe Asn Asp Lys Ala Asn Cys Val Lys His 
            260                 265                 270         


Asn Ser Ser His Thr Gly Glu Thr Ser Ser Lys Asp Asp Glu Phe Arg 
        275                 280                 285             


Lys Asn Cys Asp Lys Lys Thr Leu Phe Asp His Arg Arg Thr Gly Thr 
    290                 295                 300                 


Gly Lys Lys His Leu His Leu Asn Gln Cys Gly Lys Ser Phe Glu Lys 
305                 310                 315                 320 


Ser Thr Val Glu Glu Tyr Asn Lys Leu Asn Met Gly Ile Lys His Tyr 
                325                 330                 335     


Glu Leu Asn Pro Ser Gly Asn Asn Phe Asn Arg Lys Ala His Leu Thr 
            340                 345                 350         


Asp Pro Gln Thr Ala Val Ile Glu Glu Asn Pro Leu Val Ser Asn Asp 
        355                 360                 365             


Arg Thr Gln Thr Trp Val Lys Ser Ser Glu Tyr His Glu Asn Lys Lys 
    370                 375                 380                 


Ser Tyr Gln Thr Ser Val His Arg Val Arg Arg Arg Ser His Ser Met 
385                 390                 395                 400 


Met Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ser Phe Cys Gln Lys 
                405                 410                 415     


Gly His Leu Ile Gln His Gln Arg Thr His Thr Gly Glu Lys Pro Phe 
            420                 425                 430         


Glu Cys Ser Glu Cys Gly Lys Thr Phe Ser Gln Lys Ser His Leu Ser 
        435                 440                 445             


Thr His Gln Arg Ile His Thr Ala Glu Lys Pro Tyr Lys Cys Asn Glu 
    450                 455                 460                 


Cys Gly Lys Thr Phe Val Gln Lys Ser Thr Leu Arg Gly His Gln Arg 
465                 470                 475                 480 


Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Thr 
                485                 490                 495     


Phe Val Gln Lys Ser Thr Leu Arg Asp His His Arg Ile His Thr Gly 
            500                 505                 510         


Glu Lys Ser Phe Gln Cys Asn Gln Cys Gly Lys Thr Phe Gly Gln Lys 
        515                 520                 525             


Ser Asn Leu Arg Ile His Gln Arg Thr His Thr Gly Glu Lys Thr Tyr 
    530                 535                 540                 


Gln Cys Asn Glu Cys Glu Lys Ser Phe Trp Arg Lys Asp His Leu Ile 
545                 550                 555                 560 


Gln His Gln Lys Thr His Thr Gly Glu Lys Pro Phe Lys Cys Asn Glu 
                565                 570                 575     


Cys Gly Lys Thr Phe Ala Arg Thr Ser Thr Leu Arg Val His Gln Arg 
            580                 585                 590         


Ile His Thr Gly Glu Lys Pro Phe Lys Cys Asn Glu Cys Gly Lys Lys 
        595                 600                 605             


Phe Val Arg Lys Ala Ile Leu Ser Asp His Gln Arg Ile His Thr Gly 
    610                 615                 620                 


Glu Lys Pro Phe Gln Cys Asn Lys Cys Gly Lys Thr Phe Gly Gln Lys 
625                 630                 635                 640 


Ser Asn Leu Arg Ile His Gln Arg Thr His Ser Gly Glu Lys Ser Tyr 
                645                 650                 655     


Glu Cys Asn Glu Tyr Gly Lys Leu Cys Lys Lys Ser Thr Leu Ser Leu 
            660                 665                 670         


Tyr Gln Lys Ile Gln Gly Glu Gly Asn Pro Tyr 
        675                 680             


<210>  2381
<211>  3313
<212>  DNA
<213>  Homosapiens

<400>  2381
ctggagctgg aaaaacccgg atgccatact gctgttaaca tatgtgacac tggagacttt     60

gtccctacct catagaatcc catgcatgat gatacatgaa gggttttccg tggctatcta    120

cttctgattc ttttgaaagc tttaaagaca ttgggcatga aaggttcagt gagtttccgg    180

ggatccctcg tttgtggtag agccaggagg aaaacagttc cgttcattct ttcacagctg    240

aggctttaca gttctctata ctctcccaag agccacagaa aatgaacaca tttcaggcat    300

cagtgtcatt ccaggacgtg actgtggaat tcagccagga ggagtggcag cacatgggcc    360

ctgttgagag gaccctgtac agagatgtga tgctggagaa ctacagccac ctcgtctcag    420

tgggctactg ctttacaaaa ccagaactga tcttcacatt ggaacaagga gaagatccat    480

ggttattaga gaaagagaaa ggatttctaa gcaggaactc cccagaagac tcccaacctg    540

atgaaatctc agagaagagc ccagaaaatc aaggcaaaca tttgttgcaa gttttattca    600

ccaataaatt attgactaca gagcaagaaa tttcaggaaa accacataat cgagacataa    660

acatttttcg tgcaagaatg atgccttgta aatgtgacat tgcggggtct gcttgccagg    720

ggctcagcct gatggcccca cactgtcagt attcaaaaga aaaggctcat gagcgtaatg    780

tttgtgacaa atggctcatc agtattaagg atggcagaac taacactcaa gagaaatctt    840

tcgcttatag taaaattgtg aaaaccctcc atcataagga ggaagttatt caacatcaga    900

caattcagac tctggggcaa gattttgaat ataatgaaag tagaaaagct tttcttgaaa    960

aggctgccct tgttacatct aacagtaccc acccaaaagg aaaatcttac aatttcaata   1020

aatttgggga aaacaaatat gataaatcaa cctttattat tcctcagaac atgaatccag   1080

agaagagtca ctatgagttt aatgatactg gaaattgttt ctgtagaatc actcacaaaa   1140

ctctcacagg agggaaatcc ttcagccaaa agtcacacat tagagaacat catagagttc   1200

atataggggt gaaacccttt gaatatggaa aaagtttcaa ccgtaattca accctcccag   1260

tgcatcagag aactcatgca acagataaat actctgatta tcacccatgt acagagacat   1320

tcagctacca gtcaactttc agtgtacatc agaaggttca cataagggca aaaccctatg   1380

agtataatga atgtgggaaa tcctgctcta tgaattcaca cttgatttgg cctcagaaaa   1440

gtcacacagg ggagaaaccc tatgaatgtc ctgagtgcgg gaaagccttc agtgagaagt   1500

cacgcctaag aaaacatcag agaactcaca cgggagagaa accatacaaa tgtgatggat   1560

gtgataaagc tttcagtgca aagtcaggcc taagaataca ccagagaacc cacacagggg   1620

agaaaccatt cgaatgtcat gaatgtggga aatcttttaa ctataagtca atcctcatag   1680

tgcatcagag aactcacaca ggggagaaac cttttgaatg taatgaatgc gggaaatctt   1740

tcagccatat gtcaggccta aggaatcacc gaagaactca cacaggggaa agaccatata   1800

aatgtgatga atgtgggaaa gctttcaaac tgaagtcagg cctgaggaaa catcatagaa   1860

cacacacagg ggagaagccc tacaaatgta atcagtgtgg aaaagctttc ggtcagaaat   1920

cacaactcag aggacatcat agaattcaca caggggaaaa accctataaa tgtaatcatt   1980

gtggggaagc tttcagtcag aaatcaaacc tcagagtaca tcacagaact catactgggg   2040

agaaacccta tcaatgtgag gagtgtggaa aaacattcag gcagaaatca aatctcagag   2100

ggcatcagag aactcacact ggggagaagc cctatgaatg taatgaatgt ggaaaagctt   2160

tcagtgagaa gtcagtccta agaaaacatc agcgaactca caccggggag aaaccatata   2220

attgtaatca gtgtggggaa gctttcagtc agaaatccaa tctcagagta catcagagaa   2280

ctcacacagg ggagaaaccc tataaatgtg ataaatgtgg gagaactttc agtcaaaaat   2340

caagccttag agaacatcag aaagcccacc caggggatta aatgtatgca tataaagaat   2400

acgaaaaaac tctgagctgg aaatcaaacc tcacaataca taaatgaaca cacaggagag   2460

aactgttaac atagtgagca ctggaatttc ctctacaatt tcagcctcca ccaaatatca   2520

aagaatagaa gataaattgt tgaaatctat tttatatggg cattctttca gccagagccc   2580

agtcttctat ggatatacag aactcacaca gcaaagaaac cctataaaca taatgaatat   2640

ggaaaatact cttgcgaact cactcctcag aaaactcacg ctgcagaaaa gctctgagaa   2700

agtaataaaa atgtgaaaac tttgtgccaa caatcaaaac tcattcacca tcagagaaat   2760

cacacaatga caaaagctag aatataataa gtgtgtgata aactttaatg aaaagtcagt   2820

acagcagaaa atacattcaa gatagagacc tcatagtata ttaaaacaaa caagaaatga   2880

agttaatgga tgtgggaaat tcttctgcca tgtcaaccct cattttaacc tacacagagg   2940

taatccctat atgtcgtata ataactattg aaatgttcac tagtaatcat tttcacttct   3000

ccctcatgcc acacctggcc taaatttctc aaccactctc tcatctaaac ggggtcatat   3060

tgttaccctc tagctagtgg aatatggggt cagtgacagg tcttaaatac atcagtcaaa   3120

ttctcaatat tttcttctat ccctcattag aatggaatgg aggaaaacct tgggactcag   3180

gctctgatga tggaaagtac aagatggtag gaacccgggt cagagaagga tcctgtggca   3240

tggagttttc tcctccctgt acacagttgg acttcttgca gtgaggaaat aaatgtgttc   3300

cctgctgaac ttc                                                      3313


<210>  2382
<211>  699
<212>  PRT
<213>  Homosapiens

<400>  2382

Met Asn Thr Phe Gln Ala Ser Val Ser Phe Gln Asp Val Thr Val Glu 
1               5                   10                  15      


Phe Ser Gln Glu Glu Trp Gln His Met Gly Pro Val Glu Arg Thr Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Val Gly 
        35                  40                  45              


Tyr Cys Phe Thr Lys Pro Glu Leu Ile Phe Thr Leu Glu Gln Gly Glu 
    50                  55                  60                  


Asp Pro Trp Leu Leu Glu Lys Glu Lys Gly Phe Leu Ser Arg Asn Ser 
65                  70                  75                  80  


Pro Glu Asp Ser Gln Pro Asp Glu Ile Ser Glu Lys Ser Pro Glu Asn 
                85                  90                  95      


Gln Gly Lys His Leu Leu Gln Val Leu Phe Thr Asn Lys Leu Leu Thr 
            100                 105                 110         


Thr Glu Gln Glu Ile Ser Gly Lys Pro His Asn Arg Asp Ile Asn Ile 
        115                 120                 125             


Phe Arg Ala Arg Met Met Pro Cys Lys Cys Asp Ile Ala Gly Ser Ala 
    130                 135                 140                 


Cys Gln Gly Leu Ser Leu Met Ala Pro His Cys Gln Tyr Ser Lys Glu 
145                 150                 155                 160 


Lys Ala His Glu Arg Asn Val Cys Asp Lys Trp Leu Ile Ser Ile Lys 
                165                 170                 175     


Asp Gly Arg Thr Asn Thr Gln Glu Lys Ser Phe Ala Tyr Ser Lys Ile 
            180                 185                 190         


Val Lys Thr Leu His His Lys Glu Glu Val Ile Gln His Gln Thr Ile 
        195                 200                 205             


Gln Thr Leu Gly Gln Asp Phe Glu Tyr Asn Glu Ser Arg Lys Ala Phe 
    210                 215                 220                 


Leu Glu Lys Ala Ala Leu Val Thr Ser Asn Ser Thr His Pro Lys Gly 
225                 230                 235                 240 


Lys Ser Tyr Asn Phe Asn Lys Phe Gly Glu Asn Lys Tyr Asp Lys Ser 
                245                 250                 255     


Thr Phe Ile Ile Pro Gln Asn Met Asn Pro Glu Lys Ser His Tyr Glu 
            260                 265                 270         


Phe Asn Asp Thr Gly Asn Cys Phe Cys Arg Ile Thr His Lys Thr Leu 
        275                 280                 285             


Thr Gly Gly Lys Ser Phe Ser Gln Lys Ser His Ile Arg Glu His His 
    290                 295                 300                 


Arg Val His Ile Gly Val Lys Pro Phe Glu Tyr Gly Lys Ser Phe Asn 
305                 310                 315                 320 


Arg Asn Ser Thr Leu Pro Val His Gln Arg Thr His Ala Thr Asp Lys 
                325                 330                 335     


Tyr Ser Asp Tyr His Pro Cys Thr Glu Thr Phe Ser Tyr Gln Ser Thr 
            340                 345                 350         


Phe Ser Val His Gln Lys Val His Ile Arg Ala Lys Pro Tyr Glu Tyr 
        355                 360                 365             


Asn Glu Cys Gly Lys Ser Cys Ser Met Asn Ser His Leu Ile Trp Pro 
    370                 375                 380                 


Gln Lys Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Pro Glu Cys Gly 
385                 390                 395                 400 


Lys Ala Phe Ser Glu Lys Ser Arg Leu Arg Lys His Gln Arg Thr His 
                405                 410                 415     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Gly Cys Asp Lys Ala Phe Ser 
            420                 425                 430         


Ala Lys Ser Gly Leu Arg Ile His Gln Arg Thr His Thr Gly Glu Lys 
        435                 440                 445             


Pro Phe Glu Cys His Glu Cys Gly Lys Ser Phe Asn Tyr Lys Ser Ile 
    450                 455                 460                 


Leu Ile Val His Gln Arg Thr His Thr Gly Glu Lys Pro Phe Glu Cys 
465                 470                 475                 480 


Asn Glu Cys Gly Lys Ser Phe Ser His Met Ser Gly Leu Arg Asn His 
                485                 490                 495     


Arg Arg Thr His Thr Gly Glu Arg Pro Tyr Lys Cys Asp Glu Cys Gly 
            500                 505                 510         


Lys Ala Phe Lys Leu Lys Ser Gly Leu Arg Lys His His Arg Thr His 
        515                 520                 525             


Thr Gly Glu Lys Pro Tyr Lys Cys Asn Gln Cys Gly Lys Ala Phe Gly 
    530                 535                 540                 


Gln Lys Ser Gln Leu Arg Gly His His Arg Ile His Thr Gly Glu Lys 
545                 550                 555                 560 


Pro Tyr Lys Cys Asn His Cys Gly Glu Ala Phe Ser Gln Lys Ser Asn 
                565                 570                 575     


Leu Arg Val His His Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys 
            580                 585                 590         


Glu Glu Cys Gly Lys Thr Phe Arg Gln Lys Ser Asn Leu Arg Gly His 
        595                 600                 605             


Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly 
    610                 615                 620                 


Lys Ala Phe Ser Glu Lys Ser Val Leu Arg Lys His Gln Arg Thr His 
625                 630                 635                 640 


Thr Gly Glu Lys Pro Tyr Asn Cys Asn Gln Cys Gly Glu Ala Phe Ser 
                645                 650                 655     


Gln Lys Ser Asn Leu Arg Val His Gln Arg Thr His Thr Gly Glu Lys 
            660                 665                 670         


Pro Tyr Lys Cys Asp Lys Cys Gly Arg Thr Phe Ser Gln Lys Ser Ser 
        675                 680                 685             


Leu Arg Glu His Gln Lys Ala His Pro Gly Asp 
    690                 695                 


<210>  2383
<211>  1496
<212>  DNA
<213>  Homosapiens

<400>  2383
gctctaagcg cccggggccc cgcccagtgg ccggcacagc caatcgcagc gcgggaaggc     60

ggtgggggcg gggaaggccg cctggaaact taaatcccga ggcgggcgaa cctgcaccag    120

accgcggacg tctgtaatct cagaggcttg tttgctgagg gtgcctgcgc agctgcgacg    180

gctgctggtt ttgaaacatg aatctttcgc tcgtcctggc tgccttttgc ttgggaatag    240

cctccgctgt tccaaaattt gaccaaaatt tggatacaaa gtggtaccag tggaaggcaa    300

cacacagaag attatatggc gcgaatgaag aaggatggag gagagcagtg tgggaaaaga    360

atatgaaaat gattgaactg cacaatgggg aatacagcca agggaaacat ggcttcacaa    420

tggccatgaa tgcttttggt gacatgacca atgaagaatt caggcagatg atgggttgct    480

ttcgaaacca gaaattcagg aaggggaaag tgttccgtga gcctctgttt cttgatcttc    540

ccaaatctgt ggattggaga aagaaaggct acgtgacgcc agtgaagaat cagaaacagt    600

gtggttcttg ttgggctttt agtgcgactg gtgctcttga aggacagatg ttccggaaaa    660

ctgggaaact tgtctcactg agcgagcaga atctggtgga ctgttcgcgt cctcaaggca    720

atcagggctg caatggtggc ttcatggcta gggccttcca gtatgtcaag gagaacggag    780

gcctggactc tgaggaatcc tatccatatg tagcagtgga tgaaatctgt aagtacagac    840

ctgagaattc tgttgctaat gacactggct tcacagtggt cgcacctgga aaggagaagg    900

ccctgatgaa agcagtcgca actgtggggc ccatctccgt tgctatggat gcaggccatt    960

cgtccttcca gttctacaaa tcaggcattt attttgaacc agactgcagc agcaaaaacc   1020

tggatcatgg tgttctggtg gttggctacg gctttgaagg agcaaattcg aataacagca   1080

agtattggct cgtcaaaaac agctggggtc cagaatgggg ctcgaatggc tatgtaaaaa   1140

tagccaaaga caagaacaac cactgtggaa tcgccacagc agccagctac cccaatgtgt   1200

gagctgatgg atggtgagga ggaaggactt aaggacagca tgtctgggga aattttatct   1260

tgaaactgac caaacgctta ttgtgtaaga taaaccagtt gaatcattga ggatccaagt   1320

tgagatttta attctgtgac atttttacaa gggtaaaatg ttaccactac tttaattatt   1380

gttatacaca gctttatgat atcaaagact cattgcttaa ttctaagact tttgaatttt   1440

cattttttaa aaagatgtac aaaacagttt gaaataaatt ttaattcgta tataaa       1496


<210>  2384
<211>  334
<212>  PRT
<213>  Homosapiens

<400>  2384

Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr Gln Trp 
            20                  25                  30          


Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gly 
    50                  55                  60                  


Glu Tyr Ser Gln Gly Lys His Gly Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Met Met Gly Cys Phe Arg 
                85                  90                  95      


Asn Gln Lys Phe Arg Lys Gly Lys Val Phe Arg Glu Pro Leu Phe Leu 
            100                 105                 110         


Asp Leu Pro Lys Ser Val Asp Trp Arg Lys Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Lys Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Pro Gln Gly Asn Gln 
                165                 170                 175     


Gly Cys Asn Gly Gly Phe Met Ala Arg Ala Phe Gln Tyr Val Lys Glu 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Val Ala Val Asp 
        195                 200                 205             


Glu Ile Cys Lys Tyr Arg Pro Glu Asn Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Thr Val Val Ala Pro Gly Lys Glu Lys Ala Leu Met Lys Ala Val 
225                 230                 235                 240 


Ala Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Gly His Ser Ser 
                245                 250                 255     


Phe Gln Phe Tyr Lys Ser Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser 
            260                 265                 270         


Lys Asn Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly 
        275                 280                 285             


Ala Asn Ser Asn Asn Ser Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Glu Trp Gly Ser Asn Gly Tyr Val Lys Ile Ala Lys Asp Lys Asn 
305                 310                 315                 320 


Asn His Cys Gly Ile Ala Thr Ala Ala Ser Tyr Pro Asn Val 
                325                 330                 


<210>  2385
<211>  2311
<212>  DNA
<213>  Homosapiens

<400>  2385
tttcaggaga aatgatacca gctttttttg tacctctggt agaattcaac tgtgactcca     60

tctggtcctg ggcttttttt gattgggaag ccatgtgact tcatcctccg tggctctggt    120

ggtctcttcg acatctgtga gatactcact aaaagctggt tgcgctttga gatctgggcg    180

cctgctggaa cctggagcca caagtcttca ttcatgctaa agaactcctg tcttggtgga    240

gtggctcggc tggcccgtgt atgggaaccc atgaggctgt ccgcgcatcc cgaagtgtga    300

ccttccaggc ccacagggtg gctggcgctg ggcttcttcg tggcccgcga cagtccggcc    360

accttcatcg gccagtggcg cacggatctg ggcgactccg aagtgctccg cgagctggca    420

agggagacac tgggactctg cacccgctca gctccccaag ataaaggcct cggaggggaa    480

gttccgcgtg ggagactccg gcctgttggt ctctgtgctg gtgcggggga gccgcgtgac    540

ggcgcgcgtg ggtgtggcga cccgctggag cgctacctgg accgtcagga cccgcgctgc    600

cgctcctcca ctacccactg cccgcccccg tcgagggtcc gcaccctgtc cccgcagagg    660

gtgtcgccca cccctagccc ctgccctggt agcctggtcc cctcgagaga gcgccggcgc    720

tccgggccct aggtgacccc tattcgctta caaagcataa agcaggtgcc gaggctccca    780

ggccctggga tcagctgccc gccgcatccc cgctcctact ccgaggacag tgactcctca    840

gctttctcag cccagagccg cccccttggt gcccgcagcg aggatgaggc actaggcccg    900

gaggaagcga tccagacggg ggctgaccac caccacctgg cctctccgag acggccccct    960

gccccgcgca gccagtcccg ggaccggctg gatccgggtc agccccgggg agctccagaa   1020

gagagaggag gggagcccag ctgcgggccc tcagccctgc cccgtgggcg caggagcagg   1080

ttgggcgcaa ggatggagat gggcagcact cgtgggagcc acagggcagg ggcagcgggg   1140

ctcgggcagg agcactcctg ggctctccgt gcccaccgcc ctgaagcacc ctggctttcc   1200

cagtccaaac ccagtgtaga gtttagcacc acacgcgcca gcgtcttccg cacacaccag   1260

agcagctgct ctgacgcctg gacgaggagt ttctggccaa tgccgggacc cataaggctg   1320

ttgctagcgg gacctccact agaccagccc ctaaccgggc tccagcccca gaccctctag   1380

ctcctgactc ggcctacaga tcctctagtt cctcctcttc atccctcatt ctcttgtatg   1440

gcaaacgtgg ccaacgtggg gactctggcc ttaagaccaa tgggctgccc ggcccgctgt   1500

caagcccttc ccagctcctc ctccaatgaa ggaaagccct gccctagcat gggaggggct   1560

actagatgca cctgggagcc ccctgactgg tccagaacac tcgaggacct gagcactggg   1620

taggatggac atacagccag actgcaaacc ctcgggcatc cccatgccta gggtctcccc   1680

cgggttcctc cagacccaca gagttggggg gtgcgggggg aaggggaagg gagcttgcat   1740

gcctccagcc aggttcctgg accagaccag ctgcccccaa accctgtccc ttctcctttt   1800

cgtttgtggc cttaaccctc tttgcatcag ggggccccct ctgcctcttg cgttcctgac   1860

ttcatgggac cagactcctc aggaatgtca caatgggacc tctattgtac attacagttg   1920

ggggatgagc tttgctattt aattactaat attattgaat gccttagagg aggccagagc   1980

agcctggtat cctgaggaca cgtggcccag cagagcctct gaacagtaaa gttttgctcc   2040

agccaaaatg agagagagag agaatctatt aagttagttt aaccagaacc cccgttatcc   2100

ctgatgcttc ctgttagtaa ttttgtatcc agtgacccct gtcccttggc cataaattcc   2160

tacttgtgct tgttctattt ggaatagagc ccagttctgt actgatgtct cttttcccca   2220

actgagatag tttctaaata aaatttgcct ttgctgcttt aaaaaaaaaa aaaaaaaaaa   2280

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                  2311


<210>  2386
<211>  2374
<212>  DNA
<213>  Homosapiens

<400>  2386
atgattgaaa ggcctgaaac agatgtatct tccaagttct tatcaagaaa atgactgtga     60

gggcaacgat gggtcaagaa gaccagcgga aaactcccta ggagagagcc atagaaaatg    120

tacacttcag aagagaaatg taatcagaga actcaaaaaa ggaaaatata taatgtatgc    180

cctcggaagg gtaaaaagat ttttattcat atgcatgaga ttattcagat agatggtcat    240

atataccagt gccttgaatg caagcaaaac ttgtgtgaaa acttagctct tattatgtgt    300

gagagaaccc atactgggga gaaaccttat aaatgtgata tgtgtgagaa aacctttgtc    360

caaagctcag atcttacttc acaccagagg atccacaatt acgagaaacc ttataaatgt    420

agcaaatgtg agaagagctt ttggcatcac ttagtgcttt caggacatca gagaacacat    480

gcaggtaaaa aattctatac atgtgacatt tgtggcaaga attttggtca gagttctgat    540

ctgcttgtcc accagcgaag ccatactggc gagaaaccat atctatgtag tgagtgtgac    600

aaatgcttca gtagaagtac aaacctcata aggcatcgaa gaactcacac aggtgagaaa    660

ccatttaagt gtctcgagtg tgaaaaagct tttagtggga aatcagatct tattagccac    720

cagagaactc acactgggga aaggccctac aaatgtaata agtgtgagaa aagttaccga    780

caccgttcag ccttcattgt acataaaaga gttcatactg gggagaagcc ctataagtgt    840

ggtgcctgtg aaaaatgctt tggccagaaa tcagacctta tcgtgcacca gagagtccac    900

acaggtgaga agccgtataa atgcctggaa tgtatgagaa gttttactcg gagtgccaac    960

ctaattaggc accaggcaac tcacactcac acttttaaat gccttgaata tgaaaaaagc   1020

tttaactgta gctcagatct tattgtacat cagagaattc acatggaaga gaaaccacat   1080

cagtggtctg cgtgtgagag tggcttcctc ctaggaatgg actttgttgc ccaacagaaa   1140

atgagaactc aaacagagga gctacactat aaatacactg tatgtgataa aagcttccac   1200

cagagttcag cccttcttca acatcagaca gtacgcattg gtgaaaaacc gtttgtctgt   1260

aatgtgagtg aaaaaggtct tgagcttagc cctccccatg cgtcagaagc ctcacagatg   1320

tcttgaccag gcgagaagct gtaataccaa tattaaaaat tatttatgta tcagagaact   1380

cattaagatg aggacaaatc tcagactttg ctcagagctc agaattcagt ggggaccaga   1440

gagcctgcaa ttggaaatat gagaaattct ttgcccagag agctgcccta acagaacact   1500

tcatcctcac tccaacgaga aatctacaga tgcccagagg ttttgaaaac ttaccgtctg   1560

agctcaaatt tgatcactca caagaggatt catacaagtg ggaaacctta gaaatgcact   1620

gagtgtgaga gagctttcta ctaatgctca gcccttctcg ttgtaagaga attcacaccg   1680

gagaacaact ttttaaatgc cttcagtgtc agttgtgctg cagacagtat gaacatctca   1740

ttggacctca gaaaacccac cctggggaga agccccagca agtgtgaaaa aagcttctaa   1800

caaaactctg acttacccat cagagaagcc atactggtga aaaattgtat atttgtctta   1860

cgtatggcaa aagcattcat tggagagcct tacttgggtt tgcacccaaa aaaaaaaacc   1920

caatctgagg aaagactgca agtgtctgaa tgaagagtgc ttgtcaatga tcaactcttg   1980

tggtacatca gggaactcac ataggtgaaa aaacccatac ttaccttgag tctgagaaaa   2040

cctttggtag aagctcctgt cttatcaggc cccaaaaaac ctgttctgca gtgagagatt   2100

taattgtggg tgagaatcta tgtacatatg tatgagaaga ctgttctcat agttagttga   2160

ctcatatggt agagaggact ttacatgaaa tcagtatgaa aatagttttt tagataccca   2220

gaagcttgtt ctgggagaag ctagggcggg tcagagtaga cctgatgggt aactcaggta   2280

aagatgcttt tcttttatct gaactactta atgattgctt tacttttact ttttaaaaaa   2340

ttcagaaatc caataaagga aaggacggta acct                               2374


<210>  2387
<211>  402
<212>  PRT
<213>  Homosapiens

<400>  2387

Met Tyr Thr Ser Glu Glu Lys Cys Asn Gln Arg Thr Gln Lys Arg Lys 
1               5                   10                  15      


Ile Tyr Asn Val Cys Pro Arg Lys Gly Lys Lys Ile Phe Ile His Met 
            20                  25                  30          


His Glu Ile Ile Gln Ile Asp Gly His Ile Tyr Gln Cys Leu Glu Cys 
        35                  40                  45              


Lys Gln Asn Leu Cys Glu Asn Leu Ala Leu Ile Met Cys Glu Arg Thr 
    50                  55                  60                  


His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Met Cys Glu Lys Thr Phe 
65                  70                  75                  80  


Val Gln Ser Ser Asp Leu Thr Ser His Gln Arg Ile His Asn Tyr Glu 
                85                  90                  95      


Lys Pro Tyr Lys Cys Ser Lys Cys Glu Lys Ser Phe Trp His His Leu 
            100                 105                 110         


Val Leu Ser Gly His Gln Arg Thr His Ala Gly Lys Lys Phe Tyr Thr 
        115                 120                 125             


Cys Asp Ile Cys Gly Lys Asn Phe Gly Gln Ser Ser Asp Leu Leu Val 
    130                 135                 140                 


His Gln Arg Ser His Thr Gly Glu Lys Pro Tyr Leu Cys Ser Glu Cys 
145                 150                 155                 160 


Asp Lys Cys Phe Ser Arg Ser Thr Asn Leu Ile Arg His Arg Arg Thr 
                165                 170                 175     


His Thr Gly Glu Lys Pro Phe Lys Cys Leu Glu Cys Glu Lys Ala Phe 
            180                 185                 190         


Ser Gly Lys Ser Asp Leu Ile Ser His Gln Arg Thr His Thr Gly Glu 
        195                 200                 205             


Arg Pro Tyr Lys Cys Asn Lys Cys Glu Lys Ser Tyr Arg His Arg Ser 
    210                 215                 220                 


Ala Phe Ile Val His Lys Arg Val His Thr Gly Glu Lys Pro Tyr Lys 
225                 230                 235                 240 


Cys Gly Ala Cys Glu Lys Cys Phe Gly Gln Lys Ser Asp Leu Ile Val 
                245                 250                 255     


His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys Leu Glu Cys 
            260                 265                 270         


Met Arg Ser Phe Thr Arg Ser Ala Asn Leu Ile Arg His Gln Ala Thr 
        275                 280                 285             


His Thr His Thr Phe Lys Cys Leu Glu Tyr Glu Lys Ser Phe Asn Cys 
    290                 295                 300                 


Ser Ser Asp Leu Ile Val His Gln Arg Ile His Met Glu Glu Lys Pro 
305                 310                 315                 320 


His Gln Trp Ser Ala Cys Glu Ser Gly Phe Leu Leu Gly Met Asp Phe 
                325                 330                 335     


Val Ala Gln Gln Lys Met Arg Thr Gln Thr Glu Glu Leu His Tyr Lys 
            340                 345                 350         


Tyr Thr Val Cys Asp Lys Ser Phe His Gln Ser Ser Ala Leu Leu Gln 
        355                 360                 365             


His Gln Thr Val Arg Ile Gly Glu Lys Pro Phe Val Cys Asn Val Ser 
    370                 375                 380                 


Glu Lys Gly Leu Glu Leu Ser Pro Pro His Ala Ser Glu Ala Ser Gln 
385                 390                 395                 400 


Met Ser 
        


<210>  2388
<211>  6269
<212>  DNA
<213>  Homosapiens

<400>  2388
cagctctggc agaagcaacg gtggcttcga gggatggcgg cggctgcaac aggacctgca     60

gcatcccaga ggaactgact aagactttgg aacagaaacc agatgatgca caatattatc    120

gtcaaagagc ttattgtcac attcttcttg ggaattactg tggtgcagat gctaatttca    180

gtgactggat taaaaggtgt cgaagctcag aatggctcgg aatctgaggt gtttgtgggg    240

aagtatgaga ccctcgtgtt ttactggccc tcgctgctgt gccttgcctt cctgctgggc    300

cgcttcctgc atatgtttgt caaggctctg agggtgcacc tcggctggga gctccaggtg    360

gaagaaaaat ctgtcctgga agtgcaccag ggagagcacg tcaagcagct cctgaggata    420

ccccgccctc aagagaaaaa aaagtcttgg ttccaaacca ggatatatga gtgggatccc    480

tgctttcaat ttccaagcag aatgattgga accattgtgt tggcattcat ctgcctgtat    540

cttttcattg tcatcgagtt ctgcgtgttt gtgtacgtga gagatgagtt ggatgtgctt    600

gaaaacaacc tggaaagcta catcaccttc acgaaccatt caggggtcct gaccccagtc    660

atcctgcagg tgaaagagct gatcagtgtc accaaaggag tctgggtggc gaccattttg    720

cccgcgtatc tcacgtgtgt gagctatctg ttccacattt tggtctgtta cagaaagcac    780

atgaagaggc tatgggcagg agataaacat tttcttcctt tgaagttcca taacccggcc    840

tcgtcggaga gcatggtggc cattgcaagg tactctggct ggcaaatagc ctatattctg    900

tggggctacc tcatcattca catggtacag agcctatgtg gcatggcaat catgtacagc    960

ctggtgctac ccatcgtcca aaccagggcc tggaaatgct gcaagggctg ggcattggga   1020

tgaaagcgtt ccacaacttc aactactttc tgttcttcta caacgtgctg ctgggcctgg   1080

gtgcctgcct ttccaggctg ctcatcagtt gcctcctcgg catgtggctg attgcccgca   1140

tcgacaggac catcatgcag agtggctatg agggagcaga catggggttc agtgcatgga   1200

ttgggatgct ctacatggac cattatcaca tcaaccctgt gcttgtcagc ttttgccaca   1260

tcctgatcac aaatcacagg gagaagaagc tgcagcagag caccaaatac tggtgcctaa   1320

atcaatcggc agagtccctt cggatttgcg ccatgcgcgg cggggagaac cggcctcctg   1380

ctcgagttca gagctcatct gaggaattgg aattgagaca ccaaagccta gacgcgtttc   1440

ctggacgacg gcttcccggc aggggcatcc agccagcggc caagatgtcg tcagtgggga   1500

aggtgaccca ggttccgaat gggaaagcct accagcagat cttccaggct gaggtgcagc   1560

tggtccactc cctggcggcc accaggaagc gggctgcaga gcgttctgtg accctgaaga   1620

gtggcaggat acccatgatg aagaaggtgg agactcctga aggggaggtg atgtctcccc   1680

gacagcagaa gtggatgcac agcctcccca acgactggat catggaaaac cctgttctcc   1740

acagggaaaa ggaaagagcc aagagggaaa aagcccgaga gagtgagaac accatcgctg   1800

cccgagaagt gcggggtctc atggatacta tagttcctga gaagataagc accagcacct   1860

ttcaaaggca agcagaacac aagaggaaga gctacgagag cgctctggcc agctttcagg   1920

aggagattgc gcaggtggga aaggaaatgg aacctctcat cgtggacaca gggggacttt   1980

ttttgaagaa gctgactgag tctgatgaag aaatgaaccg tctcttccta aaggtggaaa   2040

atgacaccaa ccttgaggac tacaccatcc aagccctgct ggagctgtgg gataaggtgg   2100

ccgggcggtt actgctccgg aagcaggaga ttaaggagct ggatgaggcc ctgcactcgc   2160

tggagttctc ccgaaccgat aaactaaaaa gcgtgttgaa gaaatatgca gaagtcatag   2220

agaaaacttc ctacctcatg cggcccgaag tgtacaggct gataaatgaa gaagccatgg   2280

tcatgaacta tgccctgctg ggcaaccgga aggctctcgc ccagctgttt gtcaacctga   2340

tggagtccac cctgcagcag gagctggaca gccgccaccg ctggcaaggc ttggtggaca   2400

cctggaaggc tctcaagaag gaggccctgc tgcagagttt cagtgagttc atggccagtg   2460

agagtatcca tactcccccg gctgtgacga aggagctaga ggtcatgctg aagacccaga   2520

acgtcctgca gcaaaggcgg ctgaagcatc tctgcaccat ctgtgacctc ctgcccccca   2580

gttacagcaa aactcagctg actgagtggc attcttccct caactccctg aacaaggagc   2640

tagacaccta ccacgtggac tgcatgatgt ggatccgcct gctgtatgag aagacatggc   2700

aggagtgcct gatgcatgtg cagaattgta agaagcagct gctggactgg aaagccttca   2760

ctgaggagga ggcagagacc ctggtgaacc agttcttctt ccagatggtg ggagcactcc   2820

agggcaaagt ggaggaggac ctggagctct tggacaaatc cttcgagact ctggcagatc   2880

agacagagtg gcagagttca cacctcttca agtatttcca ggaggtggta caactgtggg   2940

aggcacacca gagcgagctg ttggtgcagg agctggagct ggagaagagg atggagcagc   3000

accggcagaa gcacagcctg gagagccagg tgcaggaggc ccacctcgat aggctcttgg   3060

accaactgag gcagcaaagt gacaaagaaa cactggcgtt tcacctggaa aaggtcaaag   3120

attatctgaa gaacatgaaa tccaggtatg aatgttttca caccctcctg acaaaggaag   3180

tgatggagta cccagcgatc atgctgaaag aactcaactc ctacagctct gccctcagcc   3240

aatacttctt tgtgcgtgaa atctttgaac agaacttggc tggagaagtc attttcaaat   3300

tcaggcaacc agaagcacat gaaaaaccct cccagaagag agtgaaaaaa ctgaggaaga   3360

agcaagggtc taaagaggac atgaccagaa gtgaggaaag cataagtagt gggacaagta   3420

ctgccaggtc agtagaagag gtggaagaag aaaacgatca agaaatggag tccttcataa   3480

ctgaagaggt gctggggcag cagaaaaaat ctccactgca tgctaagatg gatgagtcca   3540

aagaaggctc tattcaggga ctggaagaaa tgcaggttga aagagagggc tccttaaacc   3600

catccctgaa tgaggagaat gtgaagggtc aaggagaaaa gaaggaggag tcagaggagg   3660

aagatgagaa ggaggaagag gaggaggagg agaagctgga ggaagagaag gaggagaagg   3720

aggcacagga agagcaagag agtttatctg tgggtgagga agaagacaag gaagagggtc   3780

tagaggagat atactatgag gacatggagt ccttcacaat ctccagtgga aacacttatt   3840

ttgtctttgt acccctggaa gaagagcatt gtaggaagtc ccattccacc ttctcagcca   3900

tgttcatcaa cgacacttcc agtgccaagt tcatagaaca agtgacaatt ccatcgagac   3960

taattttaga aattaagaaa caattgtttt cagagggagg caacttttct cctaaagaaa   4020

tcaattcact gtgttcccga ctggagaagg aagctgcccg gatagagttg gttgaaagtg   4080

tcatcatgct caacatggag aagttggaga atgagtacct ggaccaggcc aatgatgtca   4140

tcaacaagtt tgaaagcaaa ttccataacc tgtctgtgga ccttattttc atagagaaaa   4200

tccagcggtt gctgacgaat ctgcaagtga aaatcaagtg ccaggtggca aaatccaatt   4260

cgcaaacaaa tggattaaat ttctctctgc aacagcttca gaacaagata aaaacttgtc   4320

aagagtccag gggagagaaa accacagtga ccacagaaga actcctcagc ttcgtccaaa   4380

cttggaagga aaaactgagc cagaggattc agtaccttaa ctgcagcctg gacagggtgt   4440

ccatgactga actggtcttt accaacacca tcctgaagga ccaggaggaa gacagtgaca   4500

tcctgacatc ttcagaagcc cttgaagagg aggccaagct ggacgtggtc acccctgagt   4560

ccttcaccca gctgagccgc gtggggaagc ccctgattga ggacccagct gtggatgtga   4620

tcaggaagct cctgcaactt cccaacacaa aatggccaac ccaccattgt gacaaagatc   4680

cgtcccagac aggcttcaag cgacatcggt gccagccaga aaactctggg aagaaggctg   4740

tacccagtgc cagtgctacc tctgcaggca gcctccagac cacccaccca cctttgtccc   4800

acagcttcac accgcacccc aagcccaaca aaatggagag aaagtaccgg gtgcttgggg   4860

acaagcctcc ccctgctgcc gaggatttta aggggatcat cttgaccctc ctctgggaga   4920

gcagtgagaa cctgctgaca gtcgcagagg agttctaccg taaagaaaaa cgcccagtca   4980

ccaggcctga ctgcatgtgt gacacctttg accagtgcgc cgagaacatt agcaaaaaga   5040

tcctggagta tcagagccag gcaaataagt accacaactc ctgcctcata gaattacgga   5100

tccagatcag gagatttgag gagctgctgc cccaagtgtg ttggctggtg atggagaatt   5160

tcaaggaaca ccactggaaa aagtttttca cctctgtgaa ggagatccga ggacagttcg   5220

aggaacagca gaagcggctg gagaaaagaa aggacaaaaa tgcccagaag ctccatctaa   5280

atcttggaca ccccgtacat ttccaagaaa tggagtctct acacttaagt gaagaggaaa   5340

ggcaggaaga gctggacagc atgattagga tgaacaagga gaagctggag gaatgtacca   5400

gaaggaatgg ccaggttttc ataaccaact tggccacctt caccgagaag ttcctactgc   5460

agttggatga ggtggtcacc attgacgatg tccaggttgc aaggatggag ccccccaaac   5520

agaaattatc aatgctcata cgaaggaaac tcgctgggct ctccctgaag gaagagagtg   5580

agaaacccct gattgaacgt ggaagcagga agtggccagg gatcaaaccc accgaagtca   5640

ccatccaaaa caagattctt ctccagccaa catcatcgat ttccaccacc aaaaccaccc   5700

tgggccacct ggcggccgtg gaagcccgag atgctgtgta cctgaaatat ttagcatcat   5760

ttgaggagga gctaaagagg atccaggatg actgtacatc tcagataaag gaggctcagc   5820

gctggaagga cagctggaag cagtccctgc acactatcca aggcctgtat gtgtgaccct   5880

ccgccccacc atgaataaac actttcttat acagactcct tccctgtcca tctacctgcc   5940

tacctacttt ccgtccatcc ctccctccct tcatccctcc acccctgctc tgtgccgggc   6000

actgtagctt taccagcgaa caggacacag catggtccct gcccacgtgg agccctcttc   6060

ccatgaggaa ggcaagcatg aaaggggaat tccacttggt tagcagggag ggtgagtacc   6120

aggaatcagt cacttcaaat aggcaccaga gcttcaaagg acatcacctc caaacagcat   6180

gctgggcagg gcacgtcatc ttgaaaaatg aaataaaggt catgggaaaa tgatatttta   6240

atttaacaga ataaacaagt atgggttat                                     6269


<210>  2389
<211>  1646
<212>  PRT
<213>  Homosapiens

<400>  2389

Met Trp His Gly Asn His Val Gln Pro Gly Ala Thr His Arg Pro Asn 
1               5                   10                  15      


Gln Gly Leu Glu Met Leu Gln Gly Leu Gly Ile Gly Met Lys Ala Phe 
            20                  25                  30          


His Asn Phe Asn Tyr Phe Leu Phe Phe Tyr Asn Val Leu Leu Gly Leu 
        35                  40                  45              


Gly Ala Cys Leu Ser Arg Leu Leu Ile Ser Cys Leu Leu Gly Met Trp 
    50                  55                  60                  


Leu Ile Ala Arg Ile Asp Arg Thr Ile Met Gln Ser Gly Tyr Glu Gly 
65                  70                  75                  80  


Ala Asp Met Gly Phe Ser Ala Trp Ile Gly Met Leu Tyr Met Asp His 
                85                  90                  95      


Tyr His Ile Asn Pro Val Leu Val Ser Phe Cys His Ile Leu Ile Thr 
            100                 105                 110         


Asn His Arg Glu Lys Lys Leu Gln Gln Ser Thr Lys Tyr Trp Cys Leu 
        115                 120                 125             


Asn Gln Ser Ala Glu Ser Leu Arg Ile Cys Ala Met Arg Gly Gly Glu 
    130                 135                 140                 


Asn Arg Pro Pro Ala Arg Val Gln Ser Ser Ser Glu Glu Leu Glu Leu 
145                 150                 155                 160 


Arg His Gln Ser Leu Asp Ala Phe Pro Gly Arg Arg Leu Pro Gly Arg 
                165                 170                 175     


Gly Ile Gln Pro Ala Ala Lys Met Ser Ser Val Gly Lys Val Thr Gln 
            180                 185                 190         


Val Pro Asn Gly Lys Ala Tyr Gln Gln Ile Phe Gln Ala Glu Val Gln 
        195                 200                 205             


Leu Val His Ser Leu Ala Ala Thr Arg Lys Arg Ala Ala Glu Arg Ser 
    210                 215                 220                 


Val Thr Leu Lys Ser Gly Arg Ile Pro Met Met Lys Lys Val Glu Thr 
225                 230                 235                 240 


Pro Glu Gly Glu Val Met Ser Pro Arg Gln Gln Lys Trp Met His Ser 
                245                 250                 255     


Leu Pro Asn Asp Trp Ile Met Glu Asn Pro Val Leu His Arg Glu Lys 
            260                 265                 270         


Glu Arg Ala Lys Arg Glu Lys Ala Arg Glu Ser Glu Asn Thr Ile Ala 
        275                 280                 285             


Ala Arg Glu Val Arg Gly Leu Met Asp Thr Ile Val Pro Glu Lys Ile 
    290                 295                 300                 


Ser Thr Ser Thr Phe Gln Arg Gln Ala Glu His Lys Arg Lys Ser Tyr 
305                 310                 315                 320 


Glu Ser Ala Leu Ala Ser Phe Gln Glu Glu Ile Ala Gln Val Gly Lys 
                325                 330                 335     


Glu Met Glu Pro Leu Ile Val Asp Thr Gly Gly Leu Phe Leu Lys Lys 
            340                 345                 350         


Leu Thr Glu Ser Asp Glu Glu Met Asn Arg Leu Phe Leu Lys Val Glu 
        355                 360                 365             


Asn Asp Thr Asn Leu Glu Asp Tyr Thr Ile Gln Ala Leu Leu Glu Leu 
    370                 375                 380                 


Trp Asp Lys Val Ala Gly Arg Leu Leu Leu Arg Lys Gln Glu Ile Lys 
385                 390                 395                 400 


Glu Leu Asp Glu Ala Leu His Ser Leu Glu Phe Ser Arg Thr Asp Lys 
                405                 410                 415     


Leu Lys Ser Val Leu Lys Lys Tyr Ala Glu Val Ile Glu Lys Thr Ser 
            420                 425                 430         


Tyr Leu Met Arg Pro Glu Val Tyr Arg Leu Ile Asn Glu Glu Ala Met 
        435                 440                 445             


Val Met Asn Tyr Ala Leu Leu Gly Asn Arg Lys Ala Leu Ala Gln Leu 
    450                 455                 460                 


Phe Val Asn Leu Met Glu Ser Thr Leu Gln Gln Glu Leu Asp Ser Arg 
465                 470                 475                 480 


His Arg Trp Gln Gly Leu Val Asp Thr Trp Lys Ala Leu Lys Lys Glu 
                485                 490                 495     


Ala Leu Leu Gln Ser Phe Ser Glu Phe Met Ala Ser Glu Ser Ile His 
            500                 505                 510         


Thr Pro Pro Ala Val Thr Lys Glu Leu Glu Val Met Leu Lys Thr Gln 
        515                 520                 525             


Asn Val Leu Gln Gln Arg Arg Leu Lys His Leu Cys Thr Ile Cys Asp 
    530                 535                 540                 


Leu Leu Pro Pro Ser Tyr Ser Lys Thr Gln Leu Thr Glu Trp His Ser 
545                 550                 555                 560 


Ser Leu Asn Ser Leu Asn Lys Glu Leu Asp Thr Tyr His Val Asp Cys 
                565                 570                 575     


Met Met Trp Ile Arg Leu Leu Tyr Glu Lys Thr Trp Gln Glu Cys Leu 
            580                 585                 590         


Met His Val Gln Asn Cys Lys Lys Gln Leu Leu Asp Trp Lys Ala Phe 
        595                 600                 605             


Thr Glu Glu Glu Ala Glu Thr Leu Val Asn Gln Phe Phe Phe Gln Met 
    610                 615                 620                 


Val Gly Ala Leu Gln Gly Lys Val Glu Glu Asp Leu Glu Leu Leu Asp 
625                 630                 635                 640 


Lys Ser Phe Glu Thr Leu Ala Asp Gln Thr Glu Trp Gln Ser Ser His 
                645                 650                 655     


Leu Phe Lys Tyr Phe Gln Glu Val Val Gln Leu Trp Glu Ala His Gln 
            660                 665                 670         


Ser Glu Leu Leu Val Gln Glu Leu Glu Leu Glu Lys Arg Met Glu Gln 
        675                 680                 685             


His Arg Gln Lys His Ser Leu Glu Ser Gln Val Gln Glu Ala His Leu 
    690                 695                 700                 


Asp Arg Leu Leu Asp Gln Leu Arg Gln Gln Ser Asp Lys Glu Thr Leu 
705                 710                 715                 720 


Ala Phe His Leu Glu Lys Val Lys Asp Tyr Leu Lys Asn Met Lys Ser 
                725                 730                 735     


Arg Tyr Glu Cys Phe His Thr Leu Leu Thr Lys Glu Val Met Glu Tyr 
            740                 745                 750         


Pro Ala Ile Met Leu Lys Glu Leu Asn Ser Tyr Ser Ser Ala Leu Ser 
        755                 760                 765             


Gln Tyr Phe Phe Val Arg Glu Ile Phe Glu Gln Asn Leu Ala Gly Glu 
    770                 775                 780                 


Val Ile Phe Lys Phe Arg Gln Pro Glu Ala His Glu Lys Pro Ser Gln 
785                 790                 795                 800 


Lys Arg Val Lys Lys Leu Arg Lys Lys Gln Gly Ser Lys Glu Asp Met 
                805                 810                 815     


Thr Arg Ser Glu Glu Ser Ile Ser Ser Gly Thr Ser Thr Ala Arg Ser 
            820                 825                 830         


Val Glu Glu Val Glu Glu Glu Asn Asp Gln Glu Met Glu Ser Phe Ile 
        835                 840                 845             


Thr Glu Glu Val Leu Gly Gln Gln Lys Lys Ser Pro Leu His Ala Lys 
    850                 855                 860                 


Met Asp Glu Ser Lys Glu Gly Ser Ile Gln Gly Leu Glu Glu Met Gln 
865                 870                 875                 880 


Val Glu Arg Glu Gly Ser Leu Asn Pro Ser Leu Asn Glu Glu Asn Val 
                885                 890                 895     


Lys Gly Gln Gly Glu Lys Lys Glu Glu Ser Glu Glu Glu Asp Glu Lys 
            900                 905                 910         


Glu Glu Glu Glu Glu Glu Glu Lys Leu Glu Glu Glu Lys Glu Glu Lys 
        915                 920                 925             


Glu Ala Gln Glu Glu Gln Glu Ser Leu Ser Val Gly Glu Glu Glu Asp 
    930                 935                 940                 


Lys Glu Glu Gly Leu Glu Glu Ile Tyr Tyr Glu Asp Met Glu Ser Phe 
945                 950                 955                 960 


Thr Ile Ser Ser Gly Asn Thr Tyr Phe Val Phe Val Pro Leu Glu Glu 
                965                 970                 975     


Glu His Cys Arg Lys Ser His Ser Thr Phe Ser Ala Met Phe Ile Asn 
            980                 985                 990         


Asp Thr Ser Ser Ala Lys Phe Ile  Glu Gln Val Thr Ile  Pro Ser Arg 
        995                 1000                 1005             


Leu Ile  Leu Glu Ile Lys Lys  Gln Leu Phe Ser Glu  Gly Gly Asn 
    1010                 1015                 1020             


Phe Ser  Pro Lys Glu Ile Asn  Ser Leu Cys Ser Arg  Leu Glu Lys 
    1025                 1030                 1035             


Glu Ala  Ala Arg Ile Glu Leu  Val Glu Ser Val Ile  Met Leu Asn 
    1040                 1045                 1050             


Met Glu  Lys Leu Glu Asn Glu  Tyr Leu Asp Gln Ala  Asn Asp Val 
    1055                 1060                 1065             


Ile Asn  Lys Phe Glu Ser Lys  Phe His Asn Leu Ser  Val Asp Leu 
    1070                 1075                 1080             


Ile Phe  Ile Glu Lys Ile Gln  Arg Leu Leu Thr Asn  Leu Gln Val 
    1085                 1090                 1095             


Lys Ile  Lys Cys Gln Val Ala  Lys Ser Asn Ser Gln  Thr Asn Gly 
    1100                 1105                 1110             


Leu Asn  Phe Ser Leu Gln Gln  Leu Gln Asn Lys Ile  Lys Thr Cys 
    1115                 1120                 1125             


Gln Glu  Ser Arg Gly Glu Lys  Thr Thr Val Thr Thr  Glu Glu Leu 
    1130                 1135                 1140             


Leu Ser  Phe Val Gln Thr Trp  Lys Glu Lys Leu Ser  Gln Arg Ile 
    1145                 1150                 1155             


Gln Tyr  Leu Asn Cys Ser Leu  Asp Arg Val Ser Met  Thr Glu Leu 
    1160                 1165                 1170             


Val Phe  Thr Asn Thr Ile Leu  Lys Asp Gln Glu Glu  Asp Ser Asp 
    1175                 1180                 1185             


Ile Leu  Thr Ser Ser Glu Ala  Leu Glu Glu Glu Ala  Lys Leu Asp 
    1190                 1195                 1200             


Val Val  Thr Pro Glu Ser Phe  Thr Gln Leu Ser Arg  Val Gly Lys 
    1205                 1210                 1215             


Pro Leu  Ile Glu Asp Pro Ala  Val Asp Val Ile Arg  Lys Leu Leu 
    1220                 1225                 1230             


Gln Leu  Pro Asn Thr Lys Trp  Pro Thr His His Cys  Asp Lys Asp 
    1235                 1240                 1245             


Pro Ser  Gln Thr Gly Phe Lys  Arg His Arg Cys Gln  Pro Glu Asn 
    1250                 1255                 1260             


Ser Gly  Lys Lys Ala Val Pro  Ser Ala Ser Ala Thr  Ser Ala Gly 
    1265                 1270                 1275             


Ser Leu  Gln Thr Thr His Pro  Pro Leu Ser His Ser  Phe Thr Pro 
    1280                 1285                 1290             


His Pro  Lys Pro Asn Lys Met  Glu Arg Lys Tyr Arg  Val Leu Gly 
    1295                 1300                 1305             


Asp Lys  Pro Pro Pro Ala Ala  Glu Asp Phe Lys Gly  Ile Ile Leu 
    1310                 1315                 1320             


Thr Leu  Leu Trp Glu Ser Ser  Glu Asn Leu Leu Thr  Val Ala Glu 
    1325                 1330                 1335             


Glu Phe  Tyr Arg Lys Glu Lys  Arg Pro Val Thr Arg  Pro Asp Cys 
    1340                 1345                 1350             


Met Cys  Asp Thr Phe Asp Gln  Cys Ala Glu Asn Ile  Ser Lys Lys 
    1355                 1360                 1365             


Ile Leu  Glu Tyr Gln Ser Gln  Ala Asn Lys Tyr His  Asn Ser Cys 
    1370                 1375                 1380             


Leu Ile  Glu Leu Arg Ile Gln  Ile Arg Arg Phe Glu  Glu Leu Leu 
    1385                 1390                 1395             


Pro Gln  Val Cys Trp Leu Val  Met Glu Asn Phe Lys  Glu His His 
    1400                 1405                 1410             


Trp Lys  Lys Phe Phe Thr Ser  Val Lys Glu Ile Arg  Gly Gln Phe 
    1415                 1420                 1425             


Glu Glu  Gln Gln Lys Arg Leu  Glu Lys Arg Lys Asp  Lys Asn Ala 
    1430                 1435                 1440             


Gln Lys  Leu His Leu Asn Leu  Gly His Pro Val His  Phe Gln Glu 
    1445                 1450                 1455             


Met Glu  Ser Leu His Leu Ser  Glu Glu Glu Arg Gln  Glu Glu Leu 
    1460                 1465                 1470             


Asp Ser  Met Ile Arg Met Asn  Lys Glu Lys Leu Glu  Glu Cys Thr 
    1475                 1480                 1485             


Arg Arg  Asn Gly Gln Val Phe  Ile Thr Asn Leu Ala  Thr Phe Thr 
    1490                 1495                 1500             


Glu Lys  Phe Leu Leu Gln Leu  Asp Glu Val Val Thr  Ile Asp Asp 
    1505                 1510                 1515             


Val Gln  Val Ala Arg Met Glu  Pro Pro Lys Gln Lys  Leu Ser Met 
    1520                 1525                 1530             


Leu Ile  Arg Arg Lys Leu Ala  Gly Leu Ser Leu Lys  Glu Glu Ser 
    1535                 1540                 1545             


Glu Lys  Pro Leu Ile Glu Arg  Gly Ser Arg Lys Trp  Pro Gly Ile 
    1550                 1555                 1560             


Lys Pro  Thr Glu Val Thr Ile  Gln Asn Lys Ile Leu  Leu Gln Pro 
    1565                 1570                 1575             


Thr Ser  Ser Ile Ser Thr Thr  Lys Thr Thr Leu Gly  His Leu Ala 
    1580                 1585                 1590             


Ala Val  Glu Ala Arg Asp Ala  Val Tyr Leu Lys Tyr  Leu Ala Ser 
    1595                 1600                 1605             


Phe Glu  Glu Glu Leu Lys Arg  Ile Gln Asp Asp Cys  Thr Ser Gln 
    1610                 1615                 1620             


Ile Lys  Glu Ala Gln Arg Trp  Lys Asp Ser Trp Lys  Gln Ser Leu 
    1625                 1630                 1635             


His Thr  Ile Gln Gly Leu Tyr  Val 
    1640                 1645     


<210>  2390
<211>  3784
<212>  DNA
<213>  Homosapiens

<400>  2390
agcgggaggc caggctgccc tcgaagcggg gcggggcgaa gcggggcggg gccgagcagg     60

gcggggcggg ggcttgaggt gattcccaag ccgcggggcg gctccggtgg tgcggggaaa    120

ccgaaagtgg gcggcggccg cggcggggcc cctggcggag acggcggcag gagctgggcc    180

cagagacgcg gggacgggcc gtgggccccc ggaacgaggc aaagatgctg gaaggagatc    240

tggtttcaaa gatgctacga gctgttctgc agtctcataa gaatggagta gcattacccc    300

ggctccaagg agagtacaga tccttgactg gagactggat ccccttcaaa cagctaggtt    360

tccctacact agaagcctat ctgagaagtg tgccagcagt ggtcaggata gagactagta    420

gatctggaga gattacctgc tatgccatgg cctgcacaga aactgcaaga attgctcagc    480

ttgtggctcg tcaaaggagt tctaaaagga aaaccgggcg tcaagttaat tgtcagatga    540

gagtgaagaa aaccatgcca ttttttctag aaggaaaacc aaaagcaacc ctcagacaac    600

caggatttgc ttcaaatttt tctgttggca aaaaacctaa tccagcaccg ttaagagaca    660

aaggaaactc tgttggagtt aagcctgatg ctgaaatgtc tccttatatg ctacacacaa    720

ctcttggaaa tgaagcattc aaagacattc cagtgcaaag gcatgtgacc atgtccacca    780

acaacaggtt tagcccaaag gcgtcccttc aaccaccttt gcagatgcat ctctcaagaa    840

cctctactaa ggaaatgagt gataatttaa atcagactgt tgaaaaaccc aatgtcaagc    900

ctcctgcctc ttacacttat aaaatggatg aggttcaaaa tcgcataaag gaaatactaa    960

acaagcataa caatggcatt tggatatcta agcttccaca tttttacaaa gagttatata   1020

aagaagacct taatcaagga attttacaac agtttgaaca ctggcctcat atttgcacgg   1080

tggagaaacc ttgcagtggt ggccaagatt tacttcttta tccagctaag agaaagcagc   1140

ttttgagaag tgaactggat actgagaaag tacctctatc cccactacct ggtcccaaac   1200

aaacaccacc gttgaaaggg tgtccaacag ttatggcagg agactttaaa gaaaaagtgg   1260

cagacctgct ggtgaaatac acaagtggcc tttgggccag tgcacttccg aaagcatttg   1320

aggaaatgta caaagtgaaa ttccctgagg atgccttaaa aaatcttgcc tcactttctg   1380

atgtatgcag catagactac atttctggaa atccccagaa ggccattctc tatgctaaac   1440

ttccattgcc cactgacaaa atccaaaagg atgcagggca agcacatggt gataatgata   1500

tcaaggctat ggttgaacaa gagtatttgc aggtagaaga aagcattgct gaaagtgcta   1560

atacctttat ggaggacata acagttcctc ttttaatgat tccaactgaa gcatcaccat   1620

ctgtattggt ggttgaactg agcaacacaa atgaagtggt tatcaggtat gtgggcaaag   1680

actattctgc tgctcaggaa ttaatggaag atgagatgaa ggaatattac agtaagaatc   1740

ctaagatcac accagtccag gctgtgaatg ttgggcagtt gctggccgta aatgccgagg   1800

aggacgcctg gttacgggca caggtcatct caacagaaga gaacaaaata aaggtatgct   1860

atgttgacta tggttttagt gaaaatgttg aaaaaagcaa agcatacaaa ttaaacccga   1920

agttttgttc actctcattt caagctacaa aatgtaagct tgcaggcttg gaagtcctaa   1980

gcgatgaccc tgatctagtg aaggtggttg aatctttaac ttgtggaaag atctttgcag   2040

tggaaatact tgacaaagct gacattccac ttgttgttct gtacgatacc tcaggagaag   2100

atgatatcaa tatcaatgcc acctgcttga aggctatatg tgacaagtca ctagaggttc   2160

acctgcaggt tgacgccatg tacacaaatg tcaaagtaac taatatttgc tctgatggga   2220

cactctactg ccaggtgcct tgtaagggtc tgaacaagct cagtgacctt ctacgtaaga   2280

tagaggacta cttccattgc aagcacatga cctctgagtg ctttgtttca ttacccttct   2340

gtgggaaaat ctgcctcttc cattgcaaag gaaaatggtt acgagtagag atcacaaatg   2400

ttcacagcag ccgggctctt gatgttcagt tcctggactc tggcactgtg acatctgtaa   2460

aagtgtcaga gctcagggaa attccacctc ggtttctaca agaaatgatt gcaataccac   2520

ctcaggccat taagtgctgt ttagcagatc ttccacaatc tattggcatg tggacaccag   2580

atgcagtgct gtggttaaga gattctgttt tgaattgctc ggactgtagc attaaggtta   2640

caaaagtgga tgaaaccaga gggatcgcac atgtttattt atttacccct aagaacttcc   2700

ctgaccctca tcgcagtatt aatcgccaga ttacaaatgc agacttgtgg aagcatcaga   2760

aggatgtgtt tttgagtgcc atatccagtg gagctgactc tcccaacagc aaaaatggca   2820

acatgcccat gtcgggcaac actggagaga atttcagaaa gaacctcaca gatgtcatca   2880

aaaagtccat ggtggaccat acgagcgctt tctccacaga ggaactgcca cctcctgtcc   2940

acttatcaaa gccaggggaa cacatggatg tgtatgtgcc tgtggcctgt cacccaggct   3000

acttcgtcat ccagccttgg caggagatac ataagttgga agttctgatg gaagagatga   3060

ttctatatta cagcgtgtct gaagagcgcc acatagcagt ggagaaagac caagtgtatg   3120

ctgcaaaagt ggaaaataag tggcacaggg tgcttttaaa aggaatcctg accaatggac   3180

tggtatctgt gtatgagctg gattatggca aacacgaatt agtcaacata agaaaagtac   3240

agcccctagt ggacatgttc cgaaagctgc ccttccaagc agtcacagct caacttgcag   3300

gagtgaagtg caaccagtgg tctgaggagg cttctatggt gtttcgaaat catgtggaga   3360

agaaacctct ggtggcactg gtgcagacag tcattgaaaa tgctaaccct tgggaccgga   3420

aagtagtggt ctacttagtg gacacatcgt tgccagacac cgatacctgg attcatgatt   3480

ttatgtcaga gtatctgata gagctttcaa aagttaatta atgactgcct ctgaaacctt   3540

gacaactaat tcagattttt tagcaataac aaaatgtagt aggcttaaaa aaaatcttaa   3600

ctctgctaca tggctctgac tgctgtgggg gattgaaaag aatatgctta tgtttgatga   3660

aagatattta acaagttttg ttttaacaga gttgactttt caaagaaaat tgtacttgaa   3720

ttattactat aatattagaa taaaaatgtt tatcaatata aaaaaaaaaa aaaaaaaaaa   3780

aaaa                                                                3784


<210>  2391
<211>  1098
<212>  PRT
<213>  Homosapiens

<400>  2391

Met Leu Glu Gly Asp Leu Val Ser Lys Met Leu Arg Ala Val Leu Gln 
1               5                   10                  15      


Ser His Lys Asn Gly Val Ala Leu Pro Arg Leu Gln Gly Glu Tyr Arg 
            20                  25                  30          


Ser Leu Thr Gly Asp Trp Ile Pro Phe Lys Gln Leu Gly Phe Pro Thr 
        35                  40                  45              


Leu Glu Ala Tyr Leu Arg Ser Val Pro Ala Val Val Arg Ile Glu Thr 
    50                  55                  60                  


Ser Arg Ser Gly Glu Ile Thr Cys Tyr Ala Met Ala Cys Thr Glu Thr 
65                  70                  75                  80  


Ala Arg Ile Ala Gln Leu Val Ala Arg Gln Arg Ser Ser Lys Arg Lys 
                85                  90                  95      


Thr Gly Arg Gln Val Asn Cys Gln Met Arg Val Lys Lys Thr Met Pro 
            100                 105                 110         


Phe Phe Leu Glu Gly Lys Pro Lys Ala Thr Leu Arg Gln Pro Gly Phe 
        115                 120                 125             


Ala Ser Asn Phe Ser Val Gly Lys Lys Pro Asn Pro Ala Pro Leu Arg 
    130                 135                 140                 


Asp Lys Gly Asn Ser Val Gly Val Lys Pro Asp Ala Glu Met Ser Pro 
145                 150                 155                 160 


Tyr Met Leu His Thr Thr Leu Gly Asn Glu Ala Phe Lys Asp Ile Pro 
                165                 170                 175     


Val Gln Arg His Val Thr Met Ser Thr Asn Asn Arg Phe Ser Pro Lys 
            180                 185                 190         


Ala Ser Leu Gln Pro Pro Leu Gln Met His Leu Ser Arg Thr Ser Thr 
        195                 200                 205             


Lys Glu Met Ser Asp Asn Leu Asn Gln Thr Val Glu Lys Pro Asn Val 
    210                 215                 220                 


Lys Pro Pro Ala Ser Tyr Thr Tyr Lys Met Asp Glu Val Gln Asn Arg 
225                 230                 235                 240 


Ile Lys Glu Ile Leu Asn Lys His Asn Asn Gly Ile Trp Ile Ser Lys 
                245                 250                 255     


Leu Pro His Phe Tyr Lys Glu Leu Tyr Lys Glu Asp Leu Asn Gln Gly 
            260                 265                 270         


Ile Leu Gln Gln Phe Glu His Trp Pro His Ile Cys Thr Val Glu Lys 
        275                 280                 285             


Pro Cys Ser Gly Gly Gln Asp Leu Leu Leu Tyr Pro Ala Lys Arg Lys 
    290                 295                 300                 


Gln Leu Leu Arg Ser Glu Leu Asp Thr Glu Lys Val Pro Leu Ser Pro 
305                 310                 315                 320 


Leu Pro Gly Pro Lys Gln Thr Pro Pro Leu Lys Gly Cys Pro Thr Val 
                325                 330                 335     


Met Ala Gly Asp Phe Lys Glu Lys Val Ala Asp Leu Leu Val Lys Tyr 
            340                 345                 350         


Thr Ser Gly Leu Trp Ala Ser Ala Leu Pro Lys Ala Phe Glu Glu Met 
        355                 360                 365             


Tyr Lys Val Lys Phe Pro Glu Asp Ala Leu Lys Asn Leu Ala Ser Leu 
    370                 375                 380                 


Ser Asp Val Cys Ser Ile Asp Tyr Ile Ser Gly Asn Pro Gln Lys Ala 
385                 390                 395                 400 


Ile Leu Tyr Ala Lys Leu Pro Leu Pro Thr Asp Lys Ile Gln Lys Asp 
                405                 410                 415     


Ala Gly Gln Ala His Gly Asp Asn Asp Ile Lys Ala Met Val Glu Gln 
            420                 425                 430         


Glu Tyr Leu Gln Val Glu Glu Ser Ile Ala Glu Ser Ala Asn Thr Phe 
        435                 440                 445             


Met Glu Asp Ile Thr Val Pro Leu Leu Met Ile Pro Thr Glu Ala Ser 
    450                 455                 460                 


Pro Ser Val Leu Val Val Glu Leu Ser Asn Thr Asn Glu Val Val Ile 
465                 470                 475                 480 


Arg Tyr Val Gly Lys Asp Tyr Ser Ala Ala Gln Glu Leu Met Glu Asp 
                485                 490                 495     


Glu Met Lys Glu Tyr Tyr Ser Lys Asn Pro Lys Ile Thr Pro Val Gln 
            500                 505                 510         


Ala Val Asn Val Gly Gln Leu Leu Ala Val Asn Ala Glu Glu Asp Ala 
        515                 520                 525             


Trp Leu Arg Ala Gln Val Ile Ser Thr Glu Glu Asn Lys Ile Lys Val 
    530                 535                 540                 


Cys Tyr Val Asp Tyr Gly Phe Ser Glu Asn Val Glu Lys Ser Lys Ala 
545                 550                 555                 560 


Tyr Lys Leu Asn Pro Lys Phe Cys Ser Leu Ser Phe Gln Ala Thr Lys 
                565                 570                 575     


Cys Lys Leu Ala Gly Leu Glu Val Leu Ser Asp Asp Pro Asp Leu Val 
            580                 585                 590         


Lys Val Val Glu Ser Leu Thr Cys Gly Lys Ile Phe Ala Val Glu Ile 
        595                 600                 605             


Leu Asp Lys Ala Asp Ile Pro Leu Val Val Leu Tyr Asp Thr Ser Gly 
    610                 615                 620                 


Glu Asp Asp Ile Asn Ile Asn Ala Thr Cys Leu Lys Ala Ile Cys Asp 
625                 630                 635                 640 


Lys Ser Leu Glu Val His Leu Gln Val Asp Ala Met Tyr Thr Asn Val 
                645                 650                 655     


Lys Val Thr Asn Ile Cys Ser Asp Gly Thr Leu Tyr Cys Gln Val Pro 
            660                 665                 670         


Cys Lys Gly Leu Asn Lys Leu Ser Asp Leu Leu Arg Lys Ile Glu Asp 
        675                 680                 685             


Tyr Phe His Cys Lys His Met Thr Ser Glu Cys Phe Val Ser Leu Pro 
    690                 695                 700                 


Phe Cys Gly Lys Ile Cys Leu Phe His Cys Lys Gly Lys Trp Leu Arg 
705                 710                 715                 720 


Val Glu Ile Thr Asn Val His Ser Ser Arg Ala Leu Asp Val Gln Phe 
                725                 730                 735     


Leu Asp Ser Gly Thr Val Thr Ser Val Lys Val Ser Glu Leu Arg Glu 
            740                 745                 750         


Ile Pro Pro Arg Phe Leu Gln Glu Met Ile Ala Ile Pro Pro Gln Ala 
        755                 760                 765             


Ile Lys Cys Cys Leu Ala Asp Leu Pro Gln Ser Ile Gly Met Trp Thr 
    770                 775                 780                 


Pro Asp Ala Val Leu Trp Leu Arg Asp Ser Val Leu Asn Cys Ser Asp 
785                 790                 795                 800 


Cys Ser Ile Lys Val Thr Lys Val Asp Glu Thr Arg Gly Ile Ala His 
                805                 810                 815     


Val Tyr Leu Phe Thr Pro Lys Asn Phe Pro Asp Pro His Arg Ser Ile 
            820                 825                 830         


Asn Arg Gln Ile Thr Asn Ala Asp Leu Trp Lys His Gln Lys Asp Val 
        835                 840                 845             


Phe Leu Ser Ala Ile Ser Ser Gly Ala Asp Ser Pro Asn Ser Lys Asn 
    850                 855                 860                 


Gly Asn Met Pro Met Ser Gly Asn Thr Gly Glu Asn Phe Arg Lys Asn 
865                 870                 875                 880 


Leu Thr Asp Val Ile Lys Lys Ser Met Val Asp His Thr Ser Ala Phe 
                885                 890                 895     


Ser Thr Glu Glu Leu Pro Pro Pro Val His Leu Ser Lys Pro Gly Glu 
            900                 905                 910         


His Met Asp Val Tyr Val Pro Val Ala Cys His Pro Gly Tyr Phe Val 
        915                 920                 925             


Ile Gln Pro Trp Gln Glu Ile His Lys Leu Glu Val Leu Met Glu Glu 
    930                 935                 940                 


Met Ile Leu Tyr Tyr Ser Val Ser Glu Glu Arg His Ile Ala Val Glu 
945                 950                 955                 960 


Lys Asp Gln Val Tyr Ala Ala Lys Val Glu Asn Lys Trp His Arg Val 
                965                 970                 975     


Leu Leu Lys Gly Ile Leu Thr Asn Gly Leu Val Ser Val Tyr Glu Leu 
            980                 985                 990         


Asp Tyr Gly Lys His Glu Leu Val  Asn Ile Arg Lys Val  Gln Pro Leu 
        995                 1000                 1005             


Val Asp  Met Phe Arg Lys Leu  Pro Phe Gln Ala Val  Thr Ala Gln 
    1010                 1015                 1020             


Leu Ala  Gly Val Lys Cys Asn  Gln Trp Ser Glu Glu  Ala Ser Met 
    1025                 1030                 1035             


Val Phe  Arg Asn His Val Glu  Lys Lys Pro Leu Val  Ala Leu Val 
    1040                 1045                 1050             


Gln Thr  Val Ile Glu Asn Ala  Asn Pro Trp Asp Arg  Lys Val Val 
    1055                 1060                 1065             


Val Tyr  Leu Val Asp Thr Ser  Leu Pro Asp Thr Asp  Thr Trp Ile 
    1070                 1075                 1080             


His Asp  Phe Met Ser Glu Tyr  Leu Ile Glu Leu Ser  Lys Val Asn 
    1085                 1090                 1095             


<210>  2392
<211>  2665
<212>  DNA
<213>  Homosapiens

<400>  2392
agaaattcag gagacacaga caagttcttc cacgatgtcg tacagacgag aactagagaa     60

ataccgtgac ctggatgaag atgaaatcct tggagcccta acagaggaag agctgaggac    120

cctggaaaat gagctggatg agctggaccc tgataatgca ctgctgcctg caggcctgag    180

gcagaaggat cagaccacca aggcgcccac gggccccttt aaaagagagg agctcttgga    240

tcacttggaa aagcaagcaa aggagtttaa ggaccgagaa gatctggtcc cctacacagg    300

ggaaaaacga ggaaaggtct gggttcctaa gcagaagcca ctggatcctg tgctggaaag    360

tgtgacgctg gaaccggagc tggaggaagc cttggcaaat gcttcagatg cagaactctg    420

tgacattgca gcgatcctgg gcatgcacac gctcatgagt aaccagcagt actaccaggc    480

cctgagcagc agctccatca tgaacaagga ggggctcaac agcgtgatta aacccacaca    540

atacaagcct gtgcccgacg aagaaccaaa ttcaacagac gtagaggaaa cgctggaacg    600

gataaagaac aacgacccaa aacttgaaga agttaacctc aataatatcc ggaatatccc    660

catccccacc ctcaaggcat atgcagaagc cctgaaagaa aactcatatg tgaagaagtt    720

cagcatcgtg gggacacgga gtaatgaccc cgtggcgtat gcccttgctg agatgctcaa    780

ggagaacaag gtgttgaaga cactgaatgt ggaatccaac ttcatttctg gagctgggat    840

tctgcgcctg gtagaagccc tcccatacaa cacttctctg gtggaaatga aaattgacaa    900

ccagagccag cccctgggca acaaagtgga aatggagatt gtgagcatgt tggaaaaaaa    960

cgcaacactt ctcaaattcg gctaccactt tacccagcaa ggaccccggc ttcgggcatc   1020

caacgcaatg atgaacaaca atgaccttgt gaggaagagg aggcttgcgg acctgactgg   1080

gcccatcatt cccaagtgcc ggagtggtgt ctagtgtgtg gcggtggagt ccatgccttt   1140

gaactggatg tgttctattg atgacctgtg ctctgcaggg gaaaccagaa ggcaaaatgc   1200

tggcagcatg aaaccctttt gtggttcagt tctttatgca ctaaggtttt aggttgacta   1260

gtggttgtag ttgaaaattt tataaaatac cgttaatgtg aagtttttct ttagtcacag   1320

aagttgaatc tggttattat ttaaaaacta gaagccccca aaccagcaga tcttactgaa   1380

gatgatgttc cagcagcagc gacttagccc caggagccca gtttcaatgg ccttgctgtg   1440

tggtgtttca agtgcattta aaatgtgtga cacagaaacg gcacactctt ccacatgctt   1500

ttgaagtatt ataaaacact ttattacaaa tttgtcttag ctattagcaa ataaaactga   1560

ttatcattct ttattaaccc tccttggaat tttgaaaacc tcgattaaag ttgccaaatt   1620

gattactgga tccagaacac aattttcccc tcagaacaga tagacagact gaagccactg   1680

aactctgcca ggagtcaaca tgagattcct tttgctggat atgcagaaat gataggaaaa   1740

aaaccaatgg tgaaatttca agtttcaaaa accaaccttt cattaccaat cccaggcaac   1800

aaacatgtcc ctgagtgttc tttaagaaca tttgggattt atgtacaatt taatactgga   1860

gttagaactt tttccttatt gaatgccaac cttatgatgg atgtgaaaat ctacggccaa   1920

atacttttga aaacaccttt ctatattgca cagtgggcaa atggcttatg tgaggtaaga   1980

cactagaggg ataaatttcc agatcaacat ggctatggta tttagtaatg gcccagctta   2040

gagacttcag ctactgatct catcacttat tagacaaatt gctgctgacc ttacgcctgt   2100

atattaagcc tccgcaggat gccggacaat ggtgaagaaa ctccagatat caaggaattg   2160

ggaaatcctg gccaaaccac cccaagatga ttacactgaa atgtagtatt agtactgctg   2220

ccagatctct ttttaacatc atgtgcgtct cttgggatcc agcaaaagtg ttaagccaca   2280

atgcccttgt gccttttaat ataccacagt gccagttaaa ctaatatttt tgtttgttgc   2340

ttttgggagt tattttcatt agtgatttca gcaaatctca tgataaagga caaggtcaag   2400

aactccagag cactgagcag agaggctggt gatgaaaagg tgaaggcctg cgcactgaac   2460

tgtaaggcag tgggcagtac agggtaactg gaggcggggc cagggcctca gcgctatgga   2520

agagtgtcca ctgaggctgc acatggccca ggagtggcac catgttgcag ggacaaccat   2580

ccccatttgg cttctcctta aaacacaatt gcagctgcat tctgcatcgc tgaaaactgc   2640

aatataatat taaatctgtt ggtcg                                         2665


<210>  2393
<211>  359
<212>  PRT
<213>  Homosapiens

<400>  2393

Met Ser Tyr Arg Arg Glu Leu Glu Lys Tyr Arg Asp Leu Asp Glu Asp 
1               5                   10                  15      


Glu Ile Leu Gly Ala Leu Thr Glu Glu Glu Leu Arg Thr Leu Glu Asn 
            20                  25                  30          


Glu Leu Asp Glu Leu Asp Pro Asp Asn Ala Leu Leu Pro Ala Gly Leu 
        35                  40                  45              


Arg Gln Lys Asp Gln Thr Thr Lys Ala Pro Thr Gly Pro Phe Lys Arg 
    50                  55                  60                  


Glu Glu Leu Leu Asp His Leu Glu Lys Gln Ala Lys Glu Phe Lys Asp 
65                  70                  75                  80  


Arg Glu Asp Leu Val Pro Tyr Thr Gly Glu Lys Arg Gly Lys Val Trp 
                85                  90                  95      


Val Pro Lys Gln Lys Pro Leu Asp Pro Val Leu Glu Ser Val Thr Leu 
            100                 105                 110         


Glu Pro Glu Leu Glu Glu Ala Leu Ala Asn Ala Ser Asp Ala Glu Leu 
        115                 120                 125             


Cys Asp Ile Ala Ala Ile Leu Gly Met His Thr Leu Met Ser Asn Gln 
    130                 135                 140                 


Gln Tyr Tyr Gln Ala Leu Ser Ser Ser Ser Ile Met Asn Lys Glu Gly 
145                 150                 155                 160 


Leu Asn Ser Val Ile Lys Pro Thr Gln Tyr Lys Pro Val Pro Asp Glu 
                165                 170                 175     


Glu Pro Asn Ser Thr Asp Val Glu Glu Thr Leu Glu Arg Ile Lys Asn 
            180                 185                 190         


Asn Asp Pro Lys Leu Glu Glu Val Asn Leu Asn Asn Ile Arg Asn Ile 
        195                 200                 205             


Pro Ile Pro Thr Leu Lys Ala Tyr Ala Glu Ala Leu Lys Glu Asn Ser 
    210                 215                 220                 


Tyr Val Lys Lys Phe Ser Ile Val Gly Thr Arg Ser Asn Asp Pro Val 
225                 230                 235                 240 


Ala Tyr Ala Leu Ala Glu Met Leu Lys Glu Asn Lys Val Leu Lys Thr 
                245                 250                 255     


Leu Asn Val Glu Ser Asn Phe Ile Ser Gly Ala Gly Ile Leu Arg Leu 
            260                 265                 270         


Val Glu Ala Leu Pro Tyr Asn Thr Ser Leu Val Glu Met Lys Ile Asp 
        275                 280                 285             


Asn Gln Ser Gln Pro Leu Gly Asn Lys Val Glu Met Glu Ile Val Ser 
    290                 295                 300                 


Met Leu Glu Lys Asn Ala Thr Leu Leu Lys Phe Gly Tyr His Phe Thr 
305                 310                 315                 320 


Gln Gln Gly Pro Arg Leu Arg Ala Ser Asn Ala Met Met Asn Asn Asn 
                325                 330                 335     


Asp Leu Val Arg Lys Arg Arg Leu Ala Asp Leu Thr Gly Pro Ile Ile 
            340                 345                 350         


Pro Lys Cys Arg Ser Gly Val 
        355                 


<210>  2394
<211>  5786
<212>  DNA
<213>  Homosapiens

<400>  2394
gccgcccctg agcagcctcg ccttcgcctc ccgcgtttcc tgccgtccgc cctcccccgg     60

ccgagctcca ggggctgccg cctagcagct cccggcggga gagcggttca gagcgcgcac    120

gggggcgggc ggaggcggcc cggtgcgggg cggccgcgct ggagagaggc gcgcgcggag    180

acgccggccc ccctctccgc gtttgctcgc ttgctccccg cctcccgcac tccgctcgct    240

cccacccctt cccggcgtga ttgatccgtc acgggcgccg ccgctgccgc cgccgccgcg    300

gccgttctga gccgagccgg aaccctagcc cgagacggag ccggggcccg ggccggcgcc    360

attgcgcggg cgccgcggga agaccttggc gcggggcggc gggccgggcc aggccatgcg    420

ggccgagtga gccggcgccc gcagcccgcg gcgcggcatg gcttccccgc ggagctccgg    480

gcagcccggg ccgccgccgc cgccgccacc gccgcccgcg cgcctgctac tgctactgct    540

gctgccgctg ctgctgcctc tggcgcccgg ggcctggggc tgggcgcggg gcgccccccg    600

gccgccgccc agcagcccgc cgctctccat catgggcctc atgccgctca ccaaggaggt    660

ggccaagggc agcatcgggc gcggtgtgct ccccgccgtg gaactggcca tcgagcagat    720

ccgcaacgag tcactcctgc gcccctactt cctcgacctg cggctctatg acacggagtg    780

cgacaacgca aaagggttga aagccttcta cgatgcaata aaatacgggc cgaaccactt    840

gatggtgttt ggaggcgtct gtccatccgt cacatccatc attgcagagt ccctccaagg    900

ctggaatctg gtgcagcttt cttttgctgc aaccacgcct gttctagccg ataagaaaaa    960

atacccttat ttctttcgga ccgtcccatc agacaatgcg gtgaatccag ccattctgaa   1020

gttgctcaag cactaccagt ggaagcgcgt gggcacgctg acgcaagacg ttcagaggtt   1080

ctctgaggtg cggaatgacc tgactggagt tctgtatggc gaggacattg agatttcaga   1140

caccgagagc ttctccaacg atccctgtac cagtgtcaaa aagctgaagg ggaatgatgt   1200

gcggatcatc cttggccagt ttgaccagaa tatggcagca aaagtgttct gttgtgcata   1260

cgaggagaac atgtatggta gtaaatatca gtggatcatt ccgggctggt acgagccttc   1320

ttggtgggag caggtgcaca cggaagccaa ctcatcccgc tgcctccgga agaatctgct   1380

tgctgccatg gagggctaca ttggcgtgga tttcgagccc ctgagctcca agcagatcaa   1440

gaccatctca ggaaagactc cacagcagta tgagagagag tacaacaaca agcggtcagg   1500

cgtggggccc agcaagttcc acgggtacgc ctacgatggc atctgggtca tcgccaagac   1560

actgcagagg gccatggaga cactgcatgc cagcagccgg caccagcgga tccaggactt   1620

caactacacg gaccacacgc tgggcaggat catcctcaat gccatgaacg agaccaactt   1680

cttcggggtc acgggtcaag ttgtattccg gaatggggag agaatgggga ccattaaatt   1740

tactcaattt caagacagca gggaggtgaa ggtgggagag tacaacgctg tggccgacac   1800

actggagatc atcaatgaca ccatcaggtt ccaaggatcc gaaccaccaa aagacaagac   1860

catcatcctg gagcagctgc ggaagatctc cctacctctc tacagcatcc tctctgccct   1920

caccatcctc gggatgatca tggccagtgc ttttctcttc ttcaacatca agaaccggaa   1980

tcagaagctc ataaagatgt cgagtccata catgaacaac cttatcatcc ttggagggat   2040

gctctcctat gcttccatat ttctctttgg ccttgatgga tcctttgtct ctgaaaagac   2100

ctttgaaaca ctttgcaccg tcaggacctg gattctcacc gtgggctaca cgaccgcttt   2160

tggggccatg tttgcaaaga cctggagagt ccacgccatc ttcaaaaatg tgaaaatgaa   2220

gaagaagatc atcaaggacc agaaactgct tgtgatcgtg gggggcatgc tgctgatcga   2280

cctgtgtatc ctgatctgct ggcaggctgt ggaccccctg cgaaggacag tggagaagta   2340

cagcatggag ccggacccag caggacggga tatctccatc cgccctctcc tggagcactg   2400

tgagaacacc catatgacca tctggcttgg catcgtctat gcctacaagg gacttctcat   2460

gttgttcggt tgtttcttag cttgggagac ccgcaacgtc agcatccccg cactcaacga   2520

cagcaagtac atcgggatga gtgtctacaa cgtggggatc atgtgcatca tcggggccgc   2580

tgtctccttc ctgacccggg accagcccaa tgtgcagttc tgcatcgtgg ctctggtcat   2640

catcttctgc agcaccatca ccctctgcct ggtattcgtg ccgaagctca tcaccctgag   2700

aacaaaccca gatgcagcaa cgcagaacag gcgattccag ttcactcaga atcagaagaa   2760

agaagattct aaaacgtcca cctcggtcac cagtgtgaac caagccagca catcccgcct   2820

ggagggccta cagtcagaaa accatcgcct gcgaatgaag atcacagagc tggataaaga   2880

cttggaagag gtcaccatgc agctgcagga cacaccagaa aagaccacct acattaaaca   2940

gaaccactac caagagctca atgacatcct caacctggga aacttcactg agagcacaga   3000

tggaggaaag gccattttaa aaaatcacct cgatcaaaat ccccagctac agtggaacac   3060

aacagagccc tctcgaacat gcaaagatcc tatagaagat ataaactctc cagaacacat   3120

ccagcgtcgg ctgtccctcc agctccccat cctccaccac gcctacctcc catccatcgg   3180

aggcgtggac gccagctgtg tcagcccctg cgtcagcccc accgccagcc cccgccacag   3240

acatgtgcca ccctccttcc gagtcatggt ctcgggcctg taagggtggg aggcctgggc   3300

ccggggcctc ccccgtgaca gaaccacact gggcagaggg gtctgctgca gaaacactgt   3360

cggctctggc tgcggagaag ctgggcacca tggctggcct ctcaggacca ctcggatggc   3420

actcaggtgg acaggacggg gcagggggag acttggcacc tgacctcgag ccttatttgt   3480

gaagtcctta tttcttcaca aagaagagga acggaaatgg gacgtcttcc ttaacatctg   3540

caaacaagga ggcgctggga tatcaaactt gcaaaaaaaa aaaaaaaaca aaacaaaaaa   3600

aaaaactaga caaggagaga ggcactagaa ctccagctgg aagtcacgga gtggctcgag   3660

cagccttggg aagaggcaag gagcttctga agaaactgcc tctgcacaca catcactggc   3720

tgtgacccct caggctagcc cttctccact ctgggggagg aggtgggaag ggccaccagg   3780

cccccagctg ccaggccagc tgaccccagc cttcctggaa cagggagtct gcaggagcgc   3840

agacaggcac agccctggag caggcaggcc gagggctgcg gcactggagc aggctgactt   3900

acatgctcca catgggacct gtgtcaccca atgagatgtt tgttactctg gtaaatgcca   3960

cacgttaaca caataacacc cattcctggg accgtgggga tttagggcac gtcactgcag   4020

acacgctctg cagcattcac cgacagtctg tcatgcaccc accacgttgg ccacgtcctt   4080

gtgttcctat cggatgctcc cagtaaccag ggggaccacc cgagctaatc atggaatgtc   4140

tgttcccagc aaacacgata aagaaagatt gtgcacttta acctctctca tcagggccca   4200

agggctggct gggatttttt tttttttttt ttcccactaa ctttgtttct gaccaaagtg   4260

aattggaggc attctgctaa aagacatccc cgtagacata ggggagagag ttgctggctg   4320

agggcttccc ttggcttcca gaaggcagcc ttccatccag acaagccagt gagctctccc   4380

cttgggatca ctggggtgat cagtcagcag attgattctc attcataaga tcattcctcc   4440

ctttaaattg agcccctaag agcactggcc tgggagtcag acagacctgg gttcaagtcc   4500

tcagtcccct gcccactccc tacgtgactt tgatcaggtc actagtgtct ctctgagcct   4560

cagtttcccc tctgtaactt ggggttgaac taaaacacct gtcctgccta cctcacaagg   4620

tcactctgag gattgaaact tgatcttgtc caggaaagct ttgtaccaaa cagtgaagcc   4680

gccctgatcc gtgaggtatg agtatgactc tgaccttcag ccctccctac agccgggggt   4740

gtggcccaga gaagcttcca gcacagccct ctacccagaa catccgggct ggagggaggc   4800

tcccagtgac ttttctgaca ttcctagaca ggttcattct ttgctcaaga aaggcctgaa   4860

tgacaatgtc caggatgtct gcacaactga gcagctcgct cactccctaa agaaacctat   4920

tggcagcttc aacaggcagg caataatctc ttcccagaac cactgcagtc aggaataaac   4980

tgttttctcc accaggcttt gacaaaaggg cccacaggaa tcttaccaat gccaacattt   5040

caaagcaccc tatttcacgt agcatagctt tctgctcccc ttccccaaag agaggttatg   5100

gaggtactgt agcttttagg gaaaaaaaaa atgttaacac atcacaggtc aagttgaagt   5160

cattctctgt ttaggcacta aaaatcggtg ttgtcactca ctgtgtatta ccagtattta   5220

cttgctttct tgatttcacc aaaaccaaat ttaatttaaa ggaccacatt aatttttcaa   5280

agggaaagag acaattaatt gtacataatg tatacacaca caaaaaaaaa aatacctgta   5340

gaaatattat tccagcatag caggaaaaca aacaaaagta ttggactgtc ggaggtgagc   5400

ctgtgcgtct gtaacccttt gtgactcctg agcgtgcgct gtcttctagg ttaactcacg   5460

aagtacattc tctgtcttac tgatactgta ggttcaccca ttttttttta atttcctcgc   5520

aaataacaag acccacagaa gtgactctag ctacttaatg gttctgttct tttatatgca   5580

gcaaacacac cgtccatttc tgaagaggct tcggcctgaa ggcattttcc aatgatgtta   5640

gtgcacaaaa cgctttaaat tagactggaa ctgccagaat caaatgtaaa tgaggaattt   5700

ctcgtacccc tactgcatgg tatcgatttt taataaattg ttgcaaattt gtttttatga   5760

ataaaaggaa aaaacctgtc gtcttt                                        5786


<210>  2395
<211>  941
<212>  PRT
<213>  Homosapiens

<400>  2395

Met Ala Ser Pro Arg Ser Ser Gly Gln Pro Gly Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Ala Arg Leu Leu Leu Leu Leu Leu Leu Pro Leu Leu 
            20                  25                  30          


Leu Pro Leu Ala Pro Gly Ala Trp Gly Trp Ala Arg Gly Ala Pro Arg 
        35                  40                  45              


Pro Pro Pro Ser Ser Pro Pro Leu Ser Ile Met Gly Leu Met Pro Leu 
    50                  55                  60                  


Thr Lys Glu Val Ala Lys Gly Ser Ile Gly Arg Gly Val Leu Pro Ala 
65                  70                  75                  80  


Val Glu Leu Ala Ile Glu Gln Ile Arg Asn Glu Ser Leu Leu Arg Pro 
                85                  90                  95      


Tyr Phe Leu Asp Leu Arg Leu Tyr Asp Thr Glu Cys Asp Asn Ala Lys 
            100                 105                 110         


Gly Leu Lys Ala Phe Tyr Asp Ala Ile Lys Tyr Gly Pro Asn His Leu 
        115                 120                 125             


Met Val Phe Gly Gly Val Cys Pro Ser Val Thr Ser Ile Ile Ala Glu 
    130                 135                 140                 


Ser Leu Gln Gly Trp Asn Leu Val Gln Leu Ser Phe Ala Ala Thr Thr 
145                 150                 155                 160 


Pro Val Leu Ala Asp Lys Lys Lys Tyr Pro Tyr Phe Phe Arg Thr Val 
                165                 170                 175     


Pro Ser Asp Asn Ala Val Asn Pro Ala Ile Leu Lys Leu Leu Lys His 
            180                 185                 190         


Tyr Gln Trp Lys Arg Val Gly Thr Leu Thr Gln Asp Val Gln Arg Phe 
        195                 200                 205             


Ser Glu Val Arg Asn Asp Leu Thr Gly Val Leu Tyr Gly Glu Asp Ile 
    210                 215                 220                 


Glu Ile Ser Asp Thr Glu Ser Phe Ser Asn Asp Pro Cys Thr Ser Val 
225                 230                 235                 240 


Lys Lys Leu Lys Gly Asn Asp Val Arg Ile Ile Leu Gly Gln Phe Asp 
                245                 250                 255     


Gln Asn Met Ala Ala Lys Val Phe Cys Cys Ala Tyr Glu Glu Asn Met 
            260                 265                 270         


Tyr Gly Ser Lys Tyr Gln Trp Ile Ile Pro Gly Trp Tyr Glu Pro Ser 
        275                 280                 285             


Trp Trp Glu Gln Val His Thr Glu Ala Asn Ser Ser Arg Cys Leu Arg 
    290                 295                 300                 


Lys Asn Leu Leu Ala Ala Met Glu Gly Tyr Ile Gly Val Asp Phe Glu 
305                 310                 315                 320 


Pro Leu Ser Ser Lys Gln Ile Lys Thr Ile Ser Gly Lys Thr Pro Gln 
                325                 330                 335     


Gln Tyr Glu Arg Glu Tyr Asn Asn Lys Arg Ser Gly Val Gly Pro Ser 
            340                 345                 350         


Lys Phe His Gly Tyr Ala Tyr Asp Gly Ile Trp Val Ile Ala Lys Thr 
        355                 360                 365             


Leu Gln Arg Ala Met Glu Thr Leu His Ala Ser Ser Arg His Gln Arg 
    370                 375                 380                 


Ile Gln Asp Phe Asn Tyr Thr Asp His Thr Leu Gly Arg Ile Ile Leu 
385                 390                 395                 400 


Asn Ala Met Asn Glu Thr Asn Phe Phe Gly Val Thr Gly Gln Val Val 
                405                 410                 415     


Phe Arg Asn Gly Glu Arg Met Gly Thr Ile Lys Phe Thr Gln Phe Gln 
            420                 425                 430         


Asp Ser Arg Glu Val Lys Val Gly Glu Tyr Asn Ala Val Ala Asp Thr 
        435                 440                 445             


Leu Glu Ile Ile Asn Asp Thr Ile Arg Phe Gln Gly Ser Glu Pro Pro 
    450                 455                 460                 


Lys Asp Lys Thr Ile Ile Leu Glu Gln Leu Arg Lys Ile Ser Leu Pro 
465                 470                 475                 480 


Leu Tyr Ser Ile Leu Ser Ala Leu Thr Ile Leu Gly Met Ile Met Ala 
                485                 490                 495     


Ser Ala Phe Leu Phe Phe Asn Ile Lys Asn Arg Asn Gln Lys Leu Ile 
            500                 505                 510         


Lys Met Ser Ser Pro Tyr Met Asn Asn Leu Ile Ile Leu Gly Gly Met 
        515                 520                 525             


Leu Ser Tyr Ala Ser Ile Phe Leu Phe Gly Leu Asp Gly Ser Phe Val 
    530                 535                 540                 


Ser Glu Lys Thr Phe Glu Thr Leu Cys Thr Val Arg Thr Trp Ile Leu 
545                 550                 555                 560 


Thr Val Gly Tyr Thr Thr Ala Phe Gly Ala Met Phe Ala Lys Thr Trp 
                565                 570                 575     


Arg Val His Ala Ile Phe Lys Asn Val Lys Met Lys Lys Lys Ile Ile 
            580                 585                 590         


Lys Asp Gln Lys Leu Leu Val Ile Val Gly Gly Met Leu Leu Ile Asp 
        595                 600                 605             


Leu Cys Ile Leu Ile Cys Trp Gln Ala Val Asp Pro Leu Arg Arg Thr 
    610                 615                 620                 


Val Glu Lys Tyr Ser Met Glu Pro Asp Pro Ala Gly Arg Asp Ile Ser 
625                 630                 635                 640 


Ile Arg Pro Leu Leu Glu His Cys Glu Asn Thr His Met Thr Ile Trp 
                645                 650                 655     


Leu Gly Ile Val Tyr Ala Tyr Lys Gly Leu Leu Met Leu Phe Gly Cys 
            660                 665                 670         


Phe Leu Ala Trp Glu Thr Arg Asn Val Ser Ile Pro Ala Leu Asn Asp 
        675                 680                 685             


Ser Lys Tyr Ile Gly Met Ser Val Tyr Asn Val Gly Ile Met Cys Ile 
    690                 695                 700                 


Ile Gly Ala Ala Val Ser Phe Leu Thr Arg Asp Gln Pro Asn Val Gln 
705                 710                 715                 720 


Phe Cys Ile Val Ala Leu Val Ile Ile Phe Cys Ser Thr Ile Thr Leu 
                725                 730                 735     


Cys Leu Val Phe Val Pro Lys Leu Ile Thr Leu Arg Thr Asn Pro Asp 
            740                 745                 750         


Ala Ala Thr Gln Asn Arg Arg Phe Gln Phe Thr Gln Asn Gln Lys Lys 
        755                 760                 765             


Glu Asp Ser Lys Thr Ser Thr Ser Val Thr Ser Val Asn Gln Ala Ser 
    770                 775                 780                 


Thr Ser Arg Leu Glu Gly Leu Gln Ser Glu Asn His Arg Leu Arg Met 
785                 790                 795                 800 


Lys Ile Thr Glu Leu Asp Lys Asp Leu Glu Glu Val Thr Met Gln Leu 
                805                 810                 815     


Gln Asp Thr Pro Glu Lys Thr Thr Tyr Ile Lys Gln Asn His Tyr Gln 
            820                 825                 830         


Glu Leu Asn Asp Ile Leu Asn Leu Gly Asn Phe Thr Glu Ser Thr Asp 
        835                 840                 845             


Gly Gly Lys Ala Ile Leu Lys Asn His Leu Asp Gln Asn Pro Gln Leu 
    850                 855                 860                 


Gln Trp Asn Thr Thr Glu Pro Ser Arg Thr Cys Lys Asp Pro Ile Glu 
865                 870                 875                 880 


Asp Ile Asn Ser Pro Glu His Ile Gln Arg Arg Leu Ser Leu Gln Leu 
                885                 890                 895     


Pro Ile Leu His His Ala Tyr Leu Pro Ser Ile Gly Gly Val Asp Ala 
            900                 905                 910         


Ser Cys Val Ser Pro Cys Val Ser Pro Thr Ala Ser Pro Arg His Arg 
        915                 920                 925             


His Val Pro Pro Ser Phe Arg Val Met Val Ser Gly Leu 
    930                 935                 940     


<210>  2396
<211>  7147
<212>  DNA
<213>  Homosapiens

<400>  2396
gggccgcgcg tggcggcggc gatgggcgag ggcgggctgc ccccggcctt ccagctgctg     60

ctgcgcgcgt gtgaccaggg cgacacggag acggcgcggc ggctgctgga gccgggggcg    120

gcggagccag ccgagcgcgg cgcggagccg gaggcgggcg cggagccggc gggggccgag    180

gtggccgggc ccggggccgc agcggcgggg gcagtcgggg ctccggtgcc cgtggattgc    240

tcggacgagg cgggcaacac cgcactgcag ttcgccgcgg ccgggggcca cgaaccgctg    300

gtgcgcttcc tgctgcgccg cggtgcctcg gtcaacagcc gcaaccacta cggctggagc    360

gcgctcatgc aggcggccag atttgggcat gtgagtgtgg cacacctcct gttggatcac    420

ggggctgatg tcaatgccca gaaccggctg ggggccagtg tgctcactgt ggcttctcgg    480

ggcggccacc tgggtgtggt gaagctgctc ctggaagccg gtgcctttgt ggaccatcac    540

cacccttcag gcgagcaact ggggttgggc ggcagcaggg atgagccctt ggacatcaca    600

gccctgatgg ctgccatcca gcacgggcac gaggccgtgg tgcgtctact gatggagtgg    660

ggcgcggacc ccaaccacgc agcccggacc gtgggctgga gcccgctgat gctggccgca    720

ctcactgggc ggcttggagt ggcccagcag ctggtggaga agggcgccaa ccctgaccac    780

ctcagcgtgc tggagaagac cgccttcgag gttgcactgg actgcaagca cagggacctt    840

gtagactacc tggacccgct gaccaccgtc aggcccaaaa cagatgagga gaaaaggcga    900

cctgatattt tccatgcatt gaaaatggga aacttccagc tggtcaaaga gattgccgat    960

gaagacccca gccacgtgaa cttggtcaat ggggacgggg cgacgccact gatgctagca   1020

gctgttacgg ggcagctggc tctggtgcag ctgctggtgg agaggcacgc ggatgttgac   1080

aagcaggaca gcgtgcatgg ctggacggcc ctcatgcagg caacctacca tgggaataag   1140

gaaattgtga aatatctgct aaaccaaggg gccgatgtca ctcttcgtgc aaaaaatgga   1200

tacacggcct ttgacctggt gatgctgctg aatgatcccg acacggaact tgttcgactg   1260

ctggcatctg tctgcatgca ggtgaataaa gacaaaggcc ggccgagcca ccagcctccc   1320

ctgccccact cgaaggtccg acagccctgg agcatcccag tgctgcccga tgacaagggt   1380

ggactgaagt cctggtggaa ccgaatgtcc aatcggttcc gaaagctcaa actgatgcag   1440

acgctgcccc gtgggctgtc cagcaaccag cctttgcctt tctctgacga gcctgagcca   1500

gctctggact ccacaatgag ggctgccccc caggacaaga caagccgctc tgcactccct   1560

gatgcggccc ctgtgaccaa agacaatggt cctgggagca caagaggaga aaaggaagac   1620

acgttattga caaccatgct tcgaaacgga gctcccctca ccagactccc gagtgacaag   1680

ctgaaagcag tcatcccccc attcctaccc ccttccagtt ttgagctgtg gagctctgat   1740

cggtcccgga cgcgtcacaa cgggaaggca gaccccatga agactgcgct gccccagaga   1800

gccagcaggg gccaccccgt gggcggcggg ggcacagaca ctacacccgt caggcctgtt   1860

aaatttccaa gcctccccag aagcccagcc tcttctgcca attctggaaa cttcaaccac   1920

tcgcctcatt catcgggcgg ctccagtggg gtaggtgtga gccggcacgg tggggagctg   1980

cttaaccgct caggtggcag catagacaat gtcttgtccc aaatcgctgc ccagaggaaa   2040

aaagcagccg gattattgga gcagaaaccc agccatcggt caagccctgt ggggccagca   2100

ccggggtcca gcccgtctga gcttccagcc tcccctgcag gtggcagcgc tcctgttggc   2160

aagaaattgg agaccagcaa aaggcctcca tctggaactt ccactacctc caagagcacc   2220

tctccaaccc tcacgccctc cccctcaccc aaagggcaca ctgcagagtc ctcagtgtct   2280

tcctcgtcat cccatcggca gtccaagagc agtgggggct ccagcagtgg caccatcaca   2340

gatgaggatg aactgactgg aatccttaag aaattatcac ttgagaaata tcagcccatt   2400

tttgaggaac aagaggtgga catggaagcg ttcctcacac tgactgacgg tgacttgaag   2460

gagctgggaa ttaagacaga tgggtccagg cagcagattc tggcagcgat ttctgaactg   2520

aacgcaggca agggacgcga gagacaaatt ttacaggaaa ccattcacaa ctttcactct   2580

tcctttgaga gcagtgccag caacaccagg gcccctggca acagcccctg tgcgtgatcc   2640

tccttcccgc agccaccagc gtgagctctc tgaatcccgg gaccccttca cgtggccaca   2700

gccccagccc tgcccccgtc acactgctgt gccttagtca tgttgttccc tttgctcggg   2760

atgcccactt cacgtcgacg gcattcattg gtagtacttc ttgctgcaac aaacttcaac   2820

acacagagac agattcccat gtaacagtcc agtgggggtg cttctgcttg gcaggttggt   2880

tcacacagtg atgcagggac tcagctcctt tcatcctgtg ctctgccctc cccgggagcc   2940

tcagagtttg cttctggctg gcggcaaggg aaagggacga tggagaaggc acggctgctt   3000

cttacctgcc ttgctcttaa ctgacacaca tcactcctgc tcacgtcctc ttggccactg   3060

gtagtcatgt ggccccacct ggatgcagag gaggccagga tgtgcagtct ccacatagtg   3120

gcttcccagc aacaactttt gacttagatg gggggtatgt attatggtga gaggttagcc   3180

ttcctggcac atcttccctt aaaacttcta acttgcccct cctagtccaa gtcacctctc   3240

agatgaagtc ttttttgacc ccctttcagc cactgggtcc cttagtgctg tgtatgtgac   3300

tgctgtagca ttccactgca cctgctgcat acagcttaca ttggagatgt gtatgtcaaa   3360

cgcatttttc tttattgcaa agagagtcta ttatagaagg aaagaagtgg aggcctgctg   3420

tgtggatccc ttcttcttcc tagctttcag tttccttatc tgcaaagtgg aaggtcagac   3480

cagatgatgc tctggtactc cacagtgctc acctgtatca ctgcagggct ttctgcactg   3540

aaagtggaag cagaaggcta atgggtcaca ttgtgtaaag gtctctggtg ctcaaagttt   3600

ctaggcaaag aagtgaaaat ttggaatttt gtctacatcc tattaatgct gtgttcctca   3660

aaagggaatt ggcttgtgta gtttcctacc atatcatatt ttattaaatt agaggggccc   3720

tgacttttaa aacccactgg ctttctgaag tgttttccag tgaatgactc attcagccag   3780

tgcttgttgc atttatgtta gctaccaggt gccaagtgtg cagacacaat acagagcctt   3840

caggctctcg acaggcaaga gaacacctgt aaatagatgg tcccgacatt gagaggcagc   3900

atggtagagt gggcagacct tgtgctctgg actcaggttc aaagttcaga tgaagctcaa   3960

tggcctctta gttggagctt agaaccagta tgcccaaagt gctgggtctg caggaagtac   4020

ccagtcgatg gtaggctgca cagaattctg atctctacct tgagccatgc tgagccacaa   4080

gttggtctcc ttgggaggtg ccatctctca tctgtccctc ccccagccat gaaagcccat   4140

tcccctatgc tggctttcag aggctgtcgt taacttactg cccagagcct cgtagttttc   4200

ttcccctgcc ctgatggttg ggtgtttttc ctttaaattc tctcagcctt acactcacag   4260

aagccaactt tccacaggac tgaagacaaa gtgtttcatt tagctgttac tgatagacac   4320

ctttacaaag gttactaatg tcccagcctt tttaaggaga cacactcatt catcccctac   4380

tatgtgctgg cagctttacc tttgtcattt catcctcatg gccaccctgg aggtggcatt   4440

gtgtaacctc atcttgcaca ttcgggaaac ggatgcttag gagagggaag cagcttgcca   4500

gttaaacagc ccagaaggag cagatctggg gtcagaaccg gacctggtgg gcttgcaagc   4560

ctgtgccttt tccactaact cctatagact cctggagcta gaagcacttg tgattcttgt   4620

tttaatttac tgatggcttc aggggttaac agtaggccta gaattgtttg cctctgaaat   4680

tcatggcccc tgacgttatg tgctttgagg ttttgtgcct gctttttgct gtggtcctgt   4740

ttttttcata acaatatact ggtatagctt ccactcaggt aagtttgatt gaacaatgat   4800

acacagctgc accggggggt caccttttca caaatgtaga cctccatgaa ctcattggat   4860

gaccctggac agagcggggc tattcccatt ttgcagacag gacagcagag gctccagaca   4920

atgcctttcc tttctttttc actggactca agtgtccaag gcttttcatc ctaggaagtt   4980

tgtgtgctgg ttcacaagag gtccctggca ccctttctgg ggatgtttgg atgcggctgg   5040

taggcaggga agagaaaggg caccccagcg ggggcatgtg tggaggcagc acggaacatg   5100

taggttatag atcgtcaggg aggaggggtc agttgggtgc ttgtttttct gatttttggt   5160

ccttgatcac ccccttccct tcccacacgt gtccccagcc tgcctgtggc tgttcccccc   5220

acaagaagca cctcccttgc ttggcaacct tcaccagcat ttcccaaaag tatgctcctg   5280

ggaaccctag ttccacagga taataggttt ttcataaaga aacgtagggt gtgtatgtga   5340

aagtggggtg aggttccctg gttgagtagg tttggcagac actaaagcga gctacacgat   5400

catctttgct acaggcctct cacaaccttc agcatgccag catgggtcag gcctcttcac   5460

agggccaaga aactcatagc atctcccaca ttactctcat cacttctcca aggtgctttt   5520

gcaagactgg aattccttgg acaccattgg agaagccccg ctttttctgg aacagcggca   5580

accaagaggc cttgcagccc tggaagtggg tcagggccct tggtggtcac ctttttctcc   5640

ccagcagctc tgcagaggtg gcctgcttgg cagtgggaca tcaggggacc ggtcctgctt   5700

tgagatggca gggtccctgt tctgagagct ctccagcctg agggcattga gctgaggctc   5760

caccctgagc tctcctgcag ggtggagggc attgtttccc agcacccagg cagtgtcttg   5820

ctggtgtgtc gtgagtgctg gatgtccaag tccctgctgg ccacggaggg ctcctgcctc   5880

tcttcttcag cgccacaaaa ttacatggag gccagctggt tttgtgagga gattgtttat   5940

tttttaattc ttttgtttac cgaacgttta ctgagcatct accctgtgcc agccctactc   6000

gtacgctctg tctccaaaga tgaaaaagga cttctctgcc ctcaagggaa ccccacagta   6060

tcttagagga gacaatcatg tcggtgagat ggtgtggtga tgaagcctgc tgggtataca   6120

gctcagggaa agtcatcgat gatggctcag gctcagcctg ggcacgcccc agaggagaga   6180

gatggagtgg ggcctcaaag ggcaggttta ggcagaaaag aaaaagggca ttccagctgg   6240

ggcatgtgca aaggcagcac gtaatgtgta agttctagat cgtcagggag gaagggtcag   6300

ttgggtgcct gtttttctgt ttttagtcct ttaaaatgag tagaagcaac ctgttaccct   6360

ggaaagagca ctggacatag acctagtgct gcgtgatgtt gagcacgttt cttcttccct   6420

ttgagtccca gtttcccttt tggttacagg gggatagtag cccccaggga tcatgtgaaa   6480

gtgagaaagc ccttttcaca ctgtggagcg gtgcagatgt gggaaacctc aaagatggtt   6540

gcccatttta aatcctttca tctctcatct ctctttcttc tctcccttct gccctgacgt   6600

agccatggtt gggtgggtga ggccagaaga aactgcctcc ggcaagaggt agcagccgct   6660

caggtggctc tgctggcatc ggagcccaca gaagtgagga gtggccgatg gacctgccct   6720

ccaaatgtgc ctgactctgg gtcttgctgt cactggattt cctggcatgg cagacagaaa   6780

gaaagatagt ttgaccaagt cgtagaagct gatccagcgg gtaaaaaggg ggcagggaac   6840

tcgtcccttt tattcttgcc tcagagctgc ctgaagacat gggccaggcc ggaggctgga   6900

caactttgga taacgctgac ctgtacttcc aagtaaatgc ctcctgaaga gcccgggacc   6960

cttcctggga gaattctgca gccagaatga aggtgccatc agcaggaggc actgtgaagc   7020

accatcctgt cgctgtcctt gtccattcct agcaagttaa tcgtgtcttg ttaaccagca   7080

gttcctgttc aacgtgtaaa gagacctgat gttttcccta ataaagctga taacagattt   7140

tgcagga                                                             7147


<210>  2397
<211>  871
<212>  PRT
<213>  Homosapiens

<400>  2397

Met Gly Glu Gly Gly Leu Pro Pro Ala Phe Gln Leu Leu Leu Arg Ala 
1               5                   10                  15      


Cys Asp Gln Gly Asp Thr Glu Thr Ala Arg Arg Leu Leu Glu Pro Gly 
            20                  25                  30          


Ala Ala Glu Pro Ala Glu Arg Gly Ala Glu Pro Glu Ala Gly Ala Glu 
        35                  40                  45              


Pro Ala Gly Ala Glu Val Ala Gly Pro Gly Ala Ala Ala Ala Gly Ala 
    50                  55                  60                  


Val Gly Ala Pro Val Pro Val Asp Cys Ser Asp Glu Ala Gly Asn Thr 
65                  70                  75                  80  


Ala Leu Gln Phe Ala Ala Ala Gly Gly His Glu Pro Leu Val Arg Phe 
                85                  90                  95      


Leu Leu Arg Arg Gly Ala Ser Val Asn Ser Arg Asn His Tyr Gly Trp 
            100                 105                 110         


Ser Ala Leu Met Gln Ala Ala Arg Phe Gly His Val Ser Val Ala His 
        115                 120                 125             


Leu Leu Leu Asp His Gly Ala Asp Val Asn Ala Gln Asn Arg Leu Gly 
    130                 135                 140                 


Ala Ser Val Leu Thr Val Ala Ser Arg Gly Gly His Leu Gly Val Val 
145                 150                 155                 160 


Lys Leu Leu Leu Glu Ala Gly Ala Phe Val Asp His His His Pro Ser 
                165                 170                 175     


Gly Glu Gln Leu Gly Leu Gly Gly Ser Arg Asp Glu Pro Leu Asp Ile 
            180                 185                 190         


Thr Ala Leu Met Ala Ala Ile Gln His Gly His Glu Ala Val Val Arg 
        195                 200                 205             


Leu Leu Met Glu Trp Gly Ala Asp Pro Asn His Ala Ala Arg Thr Val 
    210                 215                 220                 


Gly Trp Ser Pro Leu Met Leu Ala Ala Leu Thr Gly Arg Leu Gly Val 
225                 230                 235                 240 


Ala Gln Gln Leu Val Glu Lys Gly Ala Asn Pro Asp His Leu Ser Val 
                245                 250                 255     


Leu Glu Lys Thr Ala Phe Glu Val Ala Leu Asp Cys Lys His Arg Asp 
            260                 265                 270         


Leu Val Asp Tyr Leu Asp Pro Leu Thr Thr Val Arg Pro Lys Thr Asp 
        275                 280                 285             


Glu Glu Lys Arg Arg Pro Asp Ile Phe His Ala Leu Lys Met Gly Asn 
    290                 295                 300                 


Phe Gln Leu Val Lys Glu Ile Ala Asp Glu Asp Pro Ser His Val Asn 
305                 310                 315                 320 


Leu Val Asn Gly Asp Gly Ala Thr Pro Leu Met Leu Ala Ala Val Thr 
                325                 330                 335     


Gly Gln Leu Ala Leu Val Gln Leu Leu Val Glu Arg His Ala Asp Val 
            340                 345                 350         


Asp Lys Gln Asp Ser Val His Gly Trp Thr Ala Leu Met Gln Ala Thr 
        355                 360                 365             


Tyr His Gly Asn Lys Glu Ile Val Lys Tyr Leu Leu Asn Gln Gly Ala 
    370                 375                 380                 


Asp Val Thr Leu Arg Ala Lys Asn Gly Tyr Thr Ala Phe Asp Leu Val 
385                 390                 395                 400 


Met Leu Leu Asn Asp Pro Asp Thr Glu Leu Val Arg Leu Leu Ala Ser 
                405                 410                 415     


Val Cys Met Gln Val Asn Lys Asp Lys Gly Arg Pro Ser His Gln Pro 
            420                 425                 430         


Pro Leu Pro His Ser Lys Val Arg Gln Pro Trp Ser Ile Pro Val Leu 
        435                 440                 445             


Pro Asp Asp Lys Gly Gly Leu Lys Ser Trp Trp Asn Arg Met Ser Asn 
    450                 455                 460                 


Arg Phe Arg Lys Leu Lys Leu Met Gln Thr Leu Pro Arg Gly Leu Ser 
465                 470                 475                 480 


Ser Asn Gln Pro Leu Pro Phe Ser Asp Glu Pro Glu Pro Ala Leu Asp 
                485                 490                 495     


Ser Thr Met Arg Ala Ala Pro Gln Asp Lys Thr Ser Arg Ser Ala Leu 
            500                 505                 510         


Pro Asp Ala Ala Pro Val Thr Lys Asp Asn Gly Pro Gly Ser Thr Arg 
        515                 520                 525             


Gly Glu Lys Glu Asp Thr Leu Leu Thr Thr Met Leu Arg Asn Gly Ala 
    530                 535                 540                 


Pro Leu Thr Arg Leu Pro Ser Asp Lys Leu Lys Ala Val Ile Pro Pro 
545                 550                 555                 560 


Phe Leu Pro Pro Ser Ser Phe Glu Leu Trp Ser Ser Asp Arg Ser Arg 
                565                 570                 575     


Thr Arg His Asn Gly Lys Ala Asp Pro Met Lys Thr Ala Leu Pro Gln 
            580                 585                 590         


Arg Ala Ser Arg Gly His Pro Val Gly Gly Gly Gly Thr Asp Thr Thr 
        595                 600                 605             


Pro Val Arg Pro Val Lys Phe Pro Ser Leu Pro Arg Ser Pro Ala Ser 
    610                 615                 620                 


Ser Ala Asn Ser Gly Asn Phe Asn His Ser Pro His Ser Ser Gly Gly 
625                 630                 635                 640 


Ser Ser Gly Val Gly Val Ser Arg His Gly Gly Glu Leu Leu Asn Arg 
                645                 650                 655     


Ser Gly Gly Ser Ile Asp Asn Val Leu Ser Gln Ile Ala Ala Gln Arg 
            660                 665                 670         


Lys Lys Ala Ala Gly Leu Leu Glu Gln Lys Pro Ser His Arg Ser Ser 
        675                 680                 685             


Pro Val Gly Pro Ala Pro Gly Ser Ser Pro Ser Glu Leu Pro Ala Ser 
    690                 695                 700                 


Pro Ala Gly Gly Ser Ala Pro Val Gly Lys Lys Leu Glu Thr Ser Lys 
705                 710                 715                 720 


Arg Pro Pro Ser Gly Thr Ser Thr Thr Ser Lys Ser Thr Ser Pro Thr 
                725                 730                 735     


Leu Thr Pro Ser Pro Ser Pro Lys Gly His Thr Ala Glu Ser Ser Val 
            740                 745                 750         


Ser Ser Ser Ser Ser His Arg Gln Ser Lys Ser Ser Gly Gly Ser Ser 
        755                 760                 765             


Ser Gly Thr Ile Thr Asp Glu Asp Glu Leu Thr Gly Ile Leu Lys Lys 
    770                 775                 780                 


Leu Ser Leu Glu Lys Tyr Gln Pro Ile Phe Glu Glu Gln Glu Val Asp 
785                 790                 795                 800 


Met Glu Ala Phe Leu Thr Leu Thr Asp Gly Asp Leu Lys Glu Leu Gly 
                805                 810                 815     


Ile Lys Thr Asp Gly Ser Arg Gln Gln Ile Leu Ala Ala Ile Ser Glu 
            820                 825                 830         


Leu Asn Ala Gly Lys Gly Arg Glu Arg Gln Ile Leu Gln Glu Thr Ile 
        835                 840                 845             


His Asn Phe His Ser Ser Phe Glu Ser Ser Ala Ser Asn Thr Arg Ala 
    850                 855                 860                 


Pro Gly Asn Ser Pro Cys Ala 
865                 870     


<210>  2398
<211>  1746
<212>  DNA
<213>  Homosapiens

<400>  2398
atgtgggggc gcacggcgcg gcggcgctgc ccgcgggaac tgcggcgcgg ccgggaggcg     60

ctgttggtgc tcctggcgct actggcgttg gccgggctgg gctcggtgct gcgggcgcag    120

cgtggggccg gggccggggc tgccgagccg ggacccccgc gcaccccgcg ccccgggcgg    180

cgcgagccgg tcatgccgcg gccgccggtg ccggcgaacg cgctgggcgc gcggggcgag    240

gcggtgcggc tgcagctgca gggcgaggag ctgcggctgc aggaggagag cgtgcggctg    300

caccagatta acatctacct cagcgaccgc atctcactgc accgccgcct gcccgtgcgc    360

tggaacccgc tgtgcaaaga gaagaaatat gattatgata atttgcccag gacatctgtt    420

atcatagcat tttataatga agcctggtca actctccttc ggacagttta cagtgtcctt    480

gagacatccc cggatatcct gctagaagaa gtgatccttg tagatgacta cagtgataga    540

gagcacctga aggagcgctt ggccaatgag ctttcgggac tgcccaaggt gcgcctgatc    600

cgcgccaaca agagagaggg cctggtgcga gcccggctgc tgggggcgtc tgcggcgagg    660

ggcgatgttc tgaccttcct ggactgtcac tgtgagtgcc acgaagggtg gctggagccg    720

ctgctgcaga ggatccatga agaggagtcg gcagtggtgt gcccggtgat tgatgtgatc    780

gactggaaca ccttcgaata cctggggaac tccggggagc cccagatcgg cggtttcgac    840

tggaggctgg tgttcacgtg gcacacagtt cctgagaggg agaggatacg gatgcaatcc    900

cccgtcgatg tcatcaggtc tccaacaatg gctggtgggc tgtttgctgt gagtaagaaa    960

tattttgaat atctggggtc ttatgataca ggaatggaag tttggggagg agaaaacctc   1020

gaattttcct ttaggatctg gcagtgtggt ggggttctgg aaacacaccc atgttcccat   1080

gttggccatg ttttccccaa gcaagctccc tactcccgca acaaggctct ggccaacagt   1140

gttcgtgcag ctgaagtatg gatggatgaa tttaaagagc tctactacca tcgcaacccc   1200

cgtgcccgct tggaaccttt tggggatgtg acagagagga agcagctccg ggacaagctc   1260

cagtgtaaag acttcaagtg gttcttggag actgtgtatc cagaactgca tgtgcctgag   1320

gacaggcctg gcttcttcgg gatgctccag aacaaaggac taacagacta ctgctttgac   1380

tataaccctc ccgatgaaaa ccagattgtg ggacaccagg tcattctgta cctctgtcat   1440

gggatgggcc agaatcagtt tttcgagtac acgtcccaga aagaaatacg ctataacacc   1500

caccagcctg agggctgcat tgctgtggaa gcaggaatgg atacccttat catgcatctc   1560

tgcgaagaaa ctgccccaga gaatcagaag ttcatcttgc aggaggatgg atctttattt   1620

cacgaacagt ccaagaaatg tgtccaggct gcgaggaagg agtcgagtga cagtttcgtt   1680

ccactcttac gagactgcac caactcggat catcagaaat ggttcttcaa agagcgcatg   1740

ttatga                                                              1746


<210>  2399
<211>  581
<212>  PRT
<213>  Homosapiens

<400>  2399

Met Trp Gly Arg Thr Ala Arg Arg Arg Cys Pro Arg Glu Leu Arg Arg 
1               5                   10                  15      


Gly Arg Glu Ala Leu Leu Val Leu Leu Ala Leu Leu Ala Leu Ala Gly 
            20                  25                  30          


Leu Gly Ser Val Leu Arg Ala Gln Arg Gly Ala Gly Ala Gly Ala Ala 
        35                  40                  45              


Glu Pro Gly Pro Pro Arg Thr Pro Arg Pro Gly Arg Arg Glu Pro Val 
    50                  55                  60                  


Met Pro Arg Pro Pro Val Pro Ala Asn Ala Leu Gly Ala Arg Gly Glu 
65                  70                  75                  80  


Ala Val Arg Leu Gln Leu Gln Gly Glu Glu Leu Arg Leu Gln Glu Glu 
                85                  90                  95      


Ser Val Arg Leu His Gln Ile Asn Ile Tyr Leu Ser Asp Arg Ile Ser 
            100                 105                 110         


Leu His Arg Arg Leu Pro Val Arg Trp Asn Pro Leu Cys Lys Glu Lys 
        115                 120                 125             


Lys Tyr Asp Tyr Asp Asn Leu Pro Arg Thr Ser Val Ile Ile Ala Phe 
    130                 135                 140                 


Tyr Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Leu 
145                 150                 155                 160 


Glu Thr Ser Pro Asp Ile Leu Leu Glu Glu Val Ile Leu Val Asp Asp 
                165                 170                 175     


Tyr Ser Asp Arg Glu His Leu Lys Glu Arg Leu Ala Asn Glu Leu Ser 
            180                 185                 190         


Gly Leu Pro Lys Val Arg Leu Ile Arg Ala Asn Lys Arg Glu Gly Leu 
        195                 200                 205             


Val Arg Ala Arg Leu Leu Gly Ala Ser Ala Ala Arg Gly Asp Val Leu 
    210                 215                 220                 


Thr Phe Leu Asp Cys His Cys Glu Cys His Glu Gly Trp Leu Glu Pro 
225                 230                 235                 240 


Leu Leu Gln Arg Ile His Glu Glu Glu Ser Ala Val Val Cys Pro Val 
                245                 250                 255     


Ile Asp Val Ile Asp Trp Asn Thr Phe Glu Tyr Leu Gly Asn Ser Gly 
            260                 265                 270         


Glu Pro Gln Ile Gly Gly Phe Asp Trp Arg Leu Val Phe Thr Trp His 
        275                 280                 285             


Thr Val Pro Glu Arg Glu Arg Ile Arg Met Gln Ser Pro Val Asp Val 
    290                 295                 300                 


Ile Arg Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Val Ser Lys Lys 
305                 310                 315                 320 


Tyr Phe Glu Tyr Leu Gly Ser Tyr Asp Thr Gly Met Glu Val Trp Gly 
                325                 330                 335     


Gly Glu Asn Leu Glu Phe Ser Phe Arg Ile Trp Gln Cys Gly Gly Val 
            340                 345                 350         


Leu Glu Thr His Pro Cys Ser His Val Gly His Val Phe Pro Lys Gln 
        355                 360                 365             


Ala Pro Tyr Ser Arg Asn Lys Ala Leu Ala Asn Ser Val Arg Ala Ala 
    370                 375                 380                 


Glu Val Trp Met Asp Glu Phe Lys Glu Leu Tyr Tyr His Arg Asn Pro 
385                 390                 395                 400 


Arg Ala Arg Leu Glu Pro Phe Gly Asp Val Thr Glu Arg Lys Gln Leu 
                405                 410                 415     


Arg Asp Lys Leu Gln Cys Lys Asp Phe Lys Trp Phe Leu Glu Thr Val 
            420                 425                 430         


Tyr Pro Glu Leu His Val Pro Glu Asp Arg Pro Gly Phe Phe Gly Met 
        435                 440                 445             


Leu Gln Asn Lys Gly Leu Thr Asp Tyr Cys Phe Asp Tyr Asn Pro Pro 
    450                 455                 460                 


Asp Glu Asn Gln Ile Val Gly His Gln Val Ile Leu Tyr Leu Cys His 
465                 470                 475                 480 


Gly Met Gly Gln Asn Gln Phe Phe Glu Tyr Thr Ser Gln Lys Glu Ile 
                485                 490                 495     


Arg Tyr Asn Thr His Gln Pro Glu Gly Cys Ile Ala Val Glu Ala Gly 
            500                 505                 510         


Met Asp Thr Leu Ile Met His Leu Cys Glu Glu Thr Ala Pro Glu Asn 
        515                 520                 525             


Gln Lys Phe Ile Leu Gln Glu Asp Gly Ser Leu Phe His Glu Gln Ser 
    530                 535                 540                 


Lys Lys Cys Val Gln Ala Ala Arg Lys Glu Ser Ser Asp Ser Phe Val 
545                 550                 555                 560 


Pro Leu Leu Arg Asp Cys Thr Asn Ser Asp His Gln Lys Trp Phe Phe 
                565                 570                 575     


Lys Glu Arg Met Leu 
            580     


<210>  2400
<211>  2328
<212>  DNA
<213>  Homosapiens

<400>  2400
aattctctag gttgcaaatt gggaggatta ggaacaagta agagagttcc atgcaggatg     60

gacaagaaaa aaaagtttta taccaaaaat tgtatttcat ggcattaggg cagtctactg    120

gggtaaggca ctatgcagta ctaggcaatt agaattctat tcactagcta tgtgcacaag    180

cggctcctga cctggtcatt ttggctgtaa aactattcat gcctggacag tttttgacgg    240

tgcagtcttg ctatatggtg tgagaaatgg ctgtaggaaa caacactcaa cgaagttatt    300

ccatcatccc gtgttttata tttgttgagc ttgtcatcat ggctgggaca gtgctgcttg    360

cctactactt cgaatgcact gacacttttc aggtgcatat ccaaggattc ttctgtcagg    420

acggagactt aatgaagcct tacccaggga cagaggaaga aagcttcatc acccctctgg    480

tgctctattg tgtgctggct gccaccccaa ctgctattat ttttattggt gagatatcca    540

tgtatttcat aaaatcaaca agagaatccc tgattgctca ggagaaaaca attctgaccg    600

gagaatgctg ttacctgaac cccttacttc gaaggatcat aagattcaca ggggtgtttg    660

catttggact ttttgctact gacatttttg taaacgccgg acaagtggtc actgggcact    720

taacgccata cttcctgact gtgtgcaagc caaactacac cagtgcagac tgccaagcgc    780

accaccagtt tataaacaat gggaacattt gtactgggga cctggaagtg atagaaaagg    840

ctcggagatc ctttccctcc aaacacgctg ctctgagcat ttactccgcc ttatatgcca    900

cgatgtatat tacaagcaca atcaagacga agagcagtcg actggccaag ccggtgctgt    960

gcctcggaac tctctgcaca gccttcctga caggcctcaa ccgggtctct gagtatcgga   1020

accactgctc ggacgtgatt gctggtttca tcctgggcac tgcagtggcc ctgtttctgg   1080

gaatgtgtgt ggttcataac tttaaaggaa cgcaaggatc tccttccaaa cccaagcctg   1140

aggatccccg tggagtaccc ctaatggctt tcccaaggat agaaagccct ctggaaacct   1200

taagtgcaca gaatcactct gcgtccatga ccgaagttac ctgagacgac tgatgtgtca   1260

caagctgttt tttaaaatca tcttccaatt ctatacttca aaacacacag ttgctcaatg   1320

tcaaactgtg atgacaaata ttacgtttat ctagttagaa gctaatgttt tgtacatttt   1380

ttgtatgagg aagtgatgta gcttgccctg attttttttt tttttttttg gtcagcttta   1440

atatatttat gccagaattt taaaaccaac aaaattttct tgttcaagcg tgcattgaag   1500

aaccacattt attcaatggt tgacgttgtt ttgtgatatt tgtacacaaa ttttcttttc   1560

tcagttttat aaacacagaa tataacaatt cactttaaac ttttattacc acagttgctg   1620

cctcctccag aatttttgaa ttttaataaa aggcaaactt ttgagctgca ggaaggacaa   1680

tgttggttaa taataaatct caaagtcaat tgtagaaaaa aaattgtctt caaaaagaat   1740

gttgcactct gatctcttaa caaattgtta cgttcaaagt ttaaagtgat atattaacaa   1800

agtcacctag ttatacaaac aattgtcaga gaattctgga tttggagggt attggggtta   1860

tatgattctt tcttagataa tggcctctac taaataactc aagatctttc tggaatgtct   1920

tctggcaggc aggtgccact gtcagctttt ctccaaaaag cagccaacat cagcctcccc   1980

tgtcaactca acagttttgt atctcatatt atatggactt tatatgaaaa tgaatatttt   2040

acagtttgca cagtattatt ttacagaaaa ggaatcagag aatctacaac atagggcccc   2100

agaacaacag tttcactttg tggcttttaa ttattctaga attttaactg catctcattt   2160

ttctagcatg gtgagaacta atatgtaact cctttgattg aaggagctct tttgtccgta   2220

cctatcagaa tgttttcttg acacttccat gttggctctt ctcagctttt tttgtacata   2280

tttttttttt ctaaagagaa gaaaaagtta tcacaaaatg taaaaaaa                2328


<210>  2401
<211>  325
<212>  PRT
<213>  Homosapiens

<400>  2401

Met Ala Val Gly Asn Asn Thr Gln Arg Ser Tyr Ser Ile Ile Pro Cys 
1               5                   10                  15      


Phe Ile Phe Val Glu Leu Val Ile Met Ala Gly Thr Val Leu Leu Ala 
            20                  25                  30          


Tyr Tyr Phe Glu Cys Thr Asp Thr Phe Gln Val His Ile Gln Gly Phe 
        35                  40                  45              


Phe Cys Gln Asp Gly Asp Leu Met Lys Pro Tyr Pro Gly Thr Glu Glu 
    50                  55                  60                  


Glu Ser Phe Ile Thr Pro Leu Val Leu Tyr Cys Val Leu Ala Ala Thr 
65                  70                  75                  80  


Pro Thr Ala Ile Ile Phe Ile Gly Glu Ile Ser Met Tyr Phe Ile Lys 
                85                  90                  95      


Ser Thr Arg Glu Ser Leu Ile Ala Gln Glu Lys Thr Ile Leu Thr Gly 
            100                 105                 110         


Glu Cys Cys Tyr Leu Asn Pro Leu Leu Arg Arg Ile Ile Arg Phe Thr 
        115                 120                 125             


Gly Val Phe Ala Phe Gly Leu Phe Ala Thr Asp Ile Phe Val Asn Ala 
    130                 135                 140                 


Gly Gln Val Val Thr Gly His Leu Thr Pro Tyr Phe Leu Thr Val Cys 
145                 150                 155                 160 


Lys Pro Asn Tyr Thr Ser Ala Asp Cys Gln Ala His His Gln Phe Ile 
                165                 170                 175     


Asn Asn Gly Asn Ile Cys Thr Gly Asp Leu Glu Val Ile Glu Lys Ala 
            180                 185                 190         


Arg Arg Ser Phe Pro Ser Lys His Ala Ala Leu Ser Ile Tyr Ser Ala 
        195                 200                 205             


Leu Tyr Ala Thr Met Tyr Ile Thr Ser Thr Ile Lys Thr Lys Ser Ser 
    210                 215                 220                 


Arg Leu Ala Lys Pro Val Leu Cys Leu Gly Thr Leu Cys Thr Ala Phe 
225                 230                 235                 240 


Leu Thr Gly Leu Asn Arg Val Ser Glu Tyr Arg Asn His Cys Ser Asp 
                245                 250                 255     


Val Ile Ala Gly Phe Ile Leu Gly Thr Ala Val Ala Leu Phe Leu Gly 
            260                 265                 270         


Met Cys Val Val His Asn Phe Lys Gly Thr Gln Gly Ser Pro Ser Lys 
        275                 280                 285             


Pro Lys Pro Glu Asp Pro Arg Gly Val Pro Leu Met Ala Phe Pro Arg 
    290                 295                 300                 


Ile Glu Ser Pro Leu Glu Thr Leu Ser Ala Gln Asn His Ser Ala Ser 
305                 310                 315                 320 


Met Thr Glu Val Thr 
                325 


<210>  2402
<211>  2461
<212>  DNA
<213>  Homosapiens

<400>  2402
ttaaacaaac aggagatcct gaaacctgga ccctgtgcaa gctgcagcgc caggaggagg     60

cagcggagga agcagagcgc gggatgggcg cccagcggca tctgtgatcc cgcgcacctc    120

cgccccacgg gcgcgcgcac aaacacggac acacacatac acacactcgc gcacacactc    180

gcacaaacac acactcgtac acgcccgcgc cgctcgctcg ccggcttgct ctcccacgca    240

agcggaatgc agcagcgcct ggagagcgtg tctcggaccg ccgcctgaat gtacctcgct    300

cccgggagcc ggacggccca gtagggcgca ctggaggacg ctccgctgcg ggagcctgga    360

cagtttttga cggtgcagtc ttgctatatg gtgtgagaaa tggctgtagg aaacaacact    420

caacgaagtt attccatcat cccgtgtttt atatttgttg agcttgtcat catggctggg    480

acagtgctgc ttgcctacta cttcgaatgc actgacactt ttcaggtgca tatccaagga    540

ttcttctgtc aggacggaga cttaatgaag ccttacccag ggacagagga agaaagcttc    600

atcacccctc tggtgctcta ttgtgtgctg gctgccaccc caactgctat tatttttatt    660

ggtgagatat ccatgtattt cataaaatca acaagagaat ccctgattgc tcaggagaaa    720

acaattctga ccggagaatg ctgttacctg aaccccttac ttcgaaggat cataagattc    780

acaggggtgt ttgcatttgg actttttgct actgacattt ttgtaaacgc cggacaagtg    840

gtcactgggc acttaacgcc atacttcctg actgtgtgca agccaaacta caccagtgca    900

gactgccaag cgcaccacca gtttataaac aatgggaaca tttgtactgg ggacctggaa    960

gtgatagaaa aggctcggag atcctttccc tccaaacacg ctgctctgag catttactcc   1020

gccttatatg ccacgatgta tattacaagc acaatcaaga cgaagagcag tcgactggcc   1080

aagccggtgc tgtgcctcgg aactctctgc acagccttcc tgacaggcct caaccgggtc   1140

tctgagtatc ggaaccactg ctcggacgtg attgctggtt tcatcctggg cactgcagtg   1200

gccctgtttc tgggaatgtg tgtggttcat aactttaaag gaacgcaagg atctccttcc   1260

aaacccaagc ctgaggatcc ccgtggagta cccctaatgg ctttcccaag gatagaaagc   1320

cctctggaaa ccttaagtgc acagaatcac tctgcgtcca tgaccgaagt tacctgagac   1380

gactgatgtg tcacaagctg ttttttaaaa tcatcttcca attctatact tcaaaacaca   1440

cagttgctca atgtcaaact gtgatgacaa atattacgtt tatctagtta gaagctaatg   1500

ttttgtacat tttttgtatg aggaagtgat gtagcttgcc ctgatttttt tttttttttt   1560

ttggtcagct ttaatatatt tatgccagaa ttttaaaacc aacaaaattt tcttgttcaa   1620

gcgtgcattg aagaaccaca tttattcaat ggttgacgtt gttttgtgat atttgtacac   1680

aaattttctt ttctcagttt tataaacaca gaatataaca attcacttta aacttttatt   1740

accacagttg ctgcctcctc cagaattttt gaattttaat aaaaggcaaa cttttgagct   1800

gcaggaagga caatgttggt taataataaa tctcaaagtc aattgtagaa aaaaaattgt   1860

cttcaaaaag aatgttgcac tctgatctct taacaaattg ttacgttcaa agtttaaagt   1920

gatatattaa caaagtcacc tagttataca aacaattgtc agagaattct ggatttggag   1980

ggtattgggg ttatatgatt ctttcttaga taatggcctc tactaaataa ctcaagatct   2040

ttctggaatg tcttctggca ggcaggtgcc actgtcagct tttctccaaa aagcagccaa   2100

catcagcctc ccctgtcaac tcaacagttt tgtatctcat attatatgga ctttatatga   2160

aaatgaatat tttacagttt gcacagtatt attttacaga aaaggaatca gagaatctac   2220

aacatagggc cccagaacaa cagtttcact ttgtggcttt taattattct agaattttaa   2280

ctgcatctca tttttctagc atggtgagaa ctaatatgta actcctttga ttgaaggagc   2340

tcttttgtcc gtacctatca gaatgttttc ttgacacttc catgttggct cttctcagct   2400

ttttttgtac atattttttt tttctaaaga gaagaaaaag ttatcacaaa atgtaaaaaa   2460

a                                                                   2461


<210>  2403
<211>  325
<212>  PRT
<213>  Homosapiens

<400>  2403

Met Ala Val Gly Asn Asn Thr Gln Arg Ser Tyr Ser Ile Ile Pro Cys 
1               5                   10                  15      


Phe Ile Phe Val Glu Leu Val Ile Met Ala Gly Thr Val Leu Leu Ala 
            20                  25                  30          


Tyr Tyr Phe Glu Cys Thr Asp Thr Phe Gln Val His Ile Gln Gly Phe 
        35                  40                  45              


Phe Cys Gln Asp Gly Asp Leu Met Lys Pro Tyr Pro Gly Thr Glu Glu 
    50                  55                  60                  


Glu Ser Phe Ile Thr Pro Leu Val Leu Tyr Cys Val Leu Ala Ala Thr 
65                  70                  75                  80  


Pro Thr Ala Ile Ile Phe Ile Gly Glu Ile Ser Met Tyr Phe Ile Lys 
                85                  90                  95      


Ser Thr Arg Glu Ser Leu Ile Ala Gln Glu Lys Thr Ile Leu Thr Gly 
            100                 105                 110         


Glu Cys Cys Tyr Leu Asn Pro Leu Leu Arg Arg Ile Ile Arg Phe Thr 
        115                 120                 125             


Gly Val Phe Ala Phe Gly Leu Phe Ala Thr Asp Ile Phe Val Asn Ala 
    130                 135                 140                 


Gly Gln Val Val Thr Gly His Leu Thr Pro Tyr Phe Leu Thr Val Cys 
145                 150                 155                 160 


Lys Pro Asn Tyr Thr Ser Ala Asp Cys Gln Ala His His Gln Phe Ile 
                165                 170                 175     


Asn Asn Gly Asn Ile Cys Thr Gly Asp Leu Glu Val Ile Glu Lys Ala 
            180                 185                 190         


Arg Arg Ser Phe Pro Ser Lys His Ala Ala Leu Ser Ile Tyr Ser Ala 
        195                 200                 205             


Leu Tyr Ala Thr Met Tyr Ile Thr Ser Thr Ile Lys Thr Lys Ser Ser 
    210                 215                 220                 


Arg Leu Ala Lys Pro Val Leu Cys Leu Gly Thr Leu Cys Thr Ala Phe 
225                 230                 235                 240 


Leu Thr Gly Leu Asn Arg Val Ser Glu Tyr Arg Asn His Cys Ser Asp 
                245                 250                 255     


Val Ile Ala Gly Phe Ile Leu Gly Thr Ala Val Ala Leu Phe Leu Gly 
            260                 265                 270         


Met Cys Val Val His Asn Phe Lys Gly Thr Gln Gly Ser Pro Ser Lys 
        275                 280                 285             


Pro Lys Pro Glu Asp Pro Arg Gly Val Pro Leu Met Ala Phe Pro Arg 
    290                 295                 300                 


Ile Glu Ser Pro Leu Glu Thr Leu Ser Ala Gln Asn His Ser Ala Ser 
305                 310                 315                 320 


Met Thr Glu Val Thr 
                325 


<210>  2404
<211>  2119
<212>  DNA
<213>  Homosapiens

<400>  2404
gggatgtctc tcccaagatt ccaaagagta aactttgggc catatgataa ttacattcca     60

gtcagtgaat taagcaaaaa atcatggaat cagcaacact ttgccctgtt atttcccaaa    120

ccacaacggc caggaaccaa aaggagatca aaaccttctc aaatacggga caacacggtt    180

tctataattg atgaagaaca attaagagga gatcgtagac aaccattatg gatgtaccgt    240

tctttaatga gaatttctga gagaccatct gtttatttag ctgccaggag gcagcctctc    300

aaaccaactc gtactgtcga ggtggattct aaagcagcag aaattggtaa gaaaggtgaa    360

gacaagacaa cacagaagga cacaacagat tcggaatcag aattaaaaca aggaaaaaaa    420

gattcaaaga aaggcaagga tatagagaaa ggaaaagaag aaaagctaga tgcaaagaaa    480

gatagcaaaa aaggtaaaaa ggatgcagag aagggcaaag actcagcaac agaatctgaa    540

gatgaaaaag gaggtgcaaa gaaagataac aaaaaagata aaaaggattc aaacaaaggc    600

aaagactcgg caacagaatc tgaaggtgaa aaaggaggta cagagaaaga tagcaaaaaa    660

ggtaaaaagg attcaaagaa gggcaaggat tcagccatag aattacaagc tgtaaaagca    720

gatgaaaaga aggatgagga tggaaaaaaa gatgcaaaca aaggtgatga atcgaaggat    780

gccaagaaag atgcaaagga gattaaaaaa ggtaagaaag ataagaagaa gcccagtagt    840

acagacagtg actcaaagga tgatgtcaag aaagagtcta agaaggacgc cacgaaagat    900

gccaagaaag ttgccaagaa agatactgag aaagaatctg ctgattcaaa gaaggatgca    960

aagaaaaatg ctaagaagga tgcaaagaag gatgcaaaga agaatgcaaa gaaggatgaa   1020

aagaaggatg caaagaagaa gggcaagtag gccttggata agaatttgaa ccgaaagaat   1080

aattcaaaag catatttgat gaaacaatag tggtagtctg cagctgaatt tgtgagaaaa   1140

caagaggcct caaagaatta aataattttt aaaaggtggt aaagaaggat acaaaggaga   1200

actcagcaga gatttataaa aatatataag aaagatgtta agaaaaatta aggggggatc   1260

cattgaaaga cttgaagaat acatatactt atattcgggg atatgaagga ttcaatgaat   1320

gatctctaga aagatttaaa gaagaatatt cagataagga tgttgaagat aatgacacta   1380

aatctatgga cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca   1440

cacagtttaa tgaaggctta aagaatccaa ggagacagat gttgtatcta tagatttaaa   1500

ataatctcaa gctgcatcca cagatacaaa aaaatatagg agccatgaaa tgaagttaaa   1560

caccttgtag aaagcctact ttcaagtaaa tatagcattc ctttggcaaa aagaaaaaaa   1620

aagtaaaaga aaagaaaaaa aatgtattac cacccgatga gcctacatct ttctttctga   1680

agtttaaaca accacagtca tgtttatggt tgttggatgt gccacttcca atccaaaaga   1740

agcacacttg tctcgctctg ttgccctggc tggagttcag tgacatgatc tcaggcttac   1800

tacagcctcc accttcaggt tcaagtgatt ctcctgcctc agcctctctg gtagctggga   1860

ttacagggaa ggaaaatagc tggcatttct tgctggagaa agttatcaca agtggaaagg   1920

ttaccctaga aacaaaagat gactaccgtg aggatggatt ggacattaca ccacactgga   1980

aaagtgaaac atctcattca gttggtgatc ttcctgtcat gaaagttgct tgacagctct   2040

aattacgaat tgaacacatt aaacacctgg tgaaattatc aattaaaaac atctagtcac   2100

cataaaaaaa aaaaaaaaa                                                2119


<210>  2405
<211>  348
<212>  PRT
<213>  Homosapiens

<400>  2405

Met Ser Leu Pro Arg Phe Gln Arg Val Asn Phe Gly Pro Tyr Asp Asn 
1               5                   10                  15      


Tyr Ile Pro Val Ser Glu Leu Ser Lys Lys Ser Trp Asn Gln Gln His 
            20                  25                  30          


Phe Ala Leu Leu Phe Pro Lys Pro Gln Arg Pro Gly Thr Lys Arg Arg 
        35                  40                  45              


Ser Lys Pro Ser Gln Ile Arg Asp Asn Thr Val Ser Ile Ile Asp Glu 
    50                  55                  60                  


Glu Gln Leu Arg Gly Asp Arg Arg Gln Pro Leu Trp Met Tyr Arg Ser 
65                  70                  75                  80  


Leu Met Arg Ile Ser Glu Arg Pro Ser Val Tyr Leu Ala Ala Arg Arg 
                85                  90                  95      


Gln Pro Leu Lys Pro Thr Arg Thr Val Glu Val Asp Ser Lys Ala Ala 
            100                 105                 110         


Glu Ile Gly Lys Lys Gly Glu Asp Lys Thr Thr Gln Lys Asp Thr Thr 
        115                 120                 125             


Asp Ser Glu Ser Glu Leu Lys Gln Gly Lys Lys Asp Ser Lys Lys Gly 
    130                 135                 140                 


Lys Asp Ile Glu Lys Gly Lys Glu Glu Lys Leu Asp Ala Lys Lys Asp 
145                 150                 155                 160 


Ser Lys Lys Gly Lys Lys Asp Ala Glu Lys Gly Lys Asp Ser Ala Thr 
                165                 170                 175     


Glu Ser Glu Asp Glu Lys Gly Gly Ala Lys Lys Asp Asn Lys Lys Asp 
            180                 185                 190         


Lys Lys Asp Ser Asn Lys Gly Lys Asp Ser Ala Thr Glu Ser Glu Gly 
        195                 200                 205             


Glu Lys Gly Gly Thr Glu Lys Asp Ser Lys Lys Gly Lys Lys Asp Ser 
    210                 215                 220                 


Lys Lys Gly Lys Asp Ser Ala Ile Glu Leu Gln Ala Val Lys Ala Asp 
225                 230                 235                 240 


Glu Lys Lys Asp Glu Asp Gly Lys Lys Asp Ala Asn Lys Gly Asp Glu 
                245                 250                 255     


Ser Lys Asp Ala Lys Lys Asp Ala Lys Glu Ile Lys Lys Gly Lys Lys 
            260                 265                 270         


Asp Lys Lys Lys Pro Ser Ser Thr Asp Ser Asp Ser Lys Asp Asp Val 
        275                 280                 285             


Lys Lys Glu Ser Lys Lys Asp Ala Thr Lys Asp Ala Lys Lys Val Ala 
    290                 295                 300                 


Lys Lys Asp Thr Glu Lys Glu Ser Ala Asp Ser Lys Lys Asp Ala Lys 
305                 310                 315                 320 


Lys Asn Ala Lys Lys Asp Ala Lys Lys Asp Ala Lys Lys Asn Ala Lys 
                325                 330                 335     


Lys Asp Glu Lys Lys Asp Ala Lys Lys Lys Gly Lys 
            340                 345             


<210>  2406
<211>  378
<212>  DNA
<213>  Homosapiens

<400>  2406
gtttatgtgc atgagttagc tgagggacaa ctgatttgca ttatgctcag ctgggattgg     60

cttcaatctg caagtcgcat ccagatccat tcctcatgtc tcccacggtc ctgaaaccaa    120

caagctctca ggagaagttg atggtgactg aaattctgaa aatatgcagt cagcactttt    180

gtcttcatgg aaagtgaaca catttggaaa tattggctca gcattgcagc tatacccttt    240

agacaggaaa cacactttcc agttctcctt gacagagagg ctgaagatag agtgggaaga    300

aaaatgttga tatttaaaac taaagtaaaa aagctacaga agcttctact atttcagata    360

agtaaaataa ttcatgca                                                  378


<210>  2407
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  2407

Met Gln Ser Ala Leu Leu Ser Ser Trp Lys Val Asn Thr Phe Gly Asn 
1               5                   10                  15      


Ile Gly Ser Ala Leu Gln Leu Tyr Pro Leu Asp Arg Lys His Thr Phe 
            20                  25                  30          


Gln Phe Ser Leu Thr Glu Arg Leu Lys Ile Glu Trp Glu Glu Lys Cys 
        35                  40                  45              


<210>  2408
<211>  1044
<212>  DNA
<213>  Homosapiens

<400>  2408
atgattgttc agttaatttg tactgtttgt ttcttggcag taaatacatt tcatgttaga     60

tcttcttttg atttcctgaa agcagatgac atgggtgaga ttaaccagac acttgtgtca    120

gaatttcttc ttctgggtct ttctggatac ccaaagattg agattgttta ctttgctctc    180

attctagtta tgtacctagt gattctaatt ggcaatggtg ttctaatcat agccagcatc    240

tttgattctc attttcacac accaatgtac ttcttcctgg gcaacctctc tttcctggat    300

atctgctata catcctcctc tgttccctca acattggtga gcttaatctc aaagaaaaga    360

aacatttcct tctctggatg tgcagtgcag atgttctttg ggtttgcaat ggggtcaaca    420

gaatgtctgc ttcttggcat gatggcattt gatcgttatg tggccatctg caacccactg    480

agatacccca tcatcctgag caaggtggcg tatgtattga tggcttctgt gtcctggctg    540

tccggtggaa taaattcagc tgtgcaaaca ttacttgcca tgagactgcc tttctgtggg    600

aataatatta tcaatcattt cgcatgtgaa atattagctg tcctcaagct ggcctgtgct    660

gatatatccc tcaatattat caccatggtg atatcaaata tggccttcct ggttcttcca    720

ctgatggtca tttttttctc ctatatgttc atcctctaca ccatcttgca aatgaattca    780

gccacaggaa gacgcaaggc attttccacg tgctcagctc acctgactgt ggtgatcata    840

ttttacggta ccatcttctt tatgtatgcg aaaccgaagt ctcaagacct gattggggaa    900

gaaaaattgc aagcattaga caagctcatt tctctgtttt atggggtagt gacacccatg    960

ctgaatccta tactctatag cttgagaaat aaggatgtaa aagctgctgt aaaatatttg   1020

ctgaacaaaa aaccaattca ctaa                                          1044


<210>  2409
<211>  347
<212>  PRT
<213>  Homosapiens

<400>  2409

Met Ile Val Gln Leu Ile Cys Thr Val Cys Phe Leu Ala Val Asn Thr 
1               5                   10                  15      


Phe His Val Arg Ser Ser Phe Asp Phe Leu Lys Ala Asp Asp Met Gly 
            20                  25                  30          


Glu Ile Asn Gln Thr Leu Val Ser Glu Phe Leu Leu Leu Gly Leu Ser 
        35                  40                  45              


Gly Tyr Pro Lys Ile Glu Ile Val Tyr Phe Ala Leu Ile Leu Val Met 
    50                  55                  60                  


Tyr Leu Val Ile Leu Ile Gly Asn Gly Val Leu Ile Ile Ala Ser Ile 
65                  70                  75                  80  


Phe Asp Ser His Phe His Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu 
                85                  90                  95      


Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Val Pro Ser Thr Leu 
            100                 105                 110         


Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly Cys Ala 
        115                 120                 125             


Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys Leu Leu 
    130                 135                 140                 


Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 
145                 150                 155                 160 


Arg Tyr Pro Ile Ile Leu Ser Lys Val Ala Tyr Val Leu Met Ala Ser 
                165                 170                 175     


Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Ala Val Gln Thr Leu Leu 
            180                 185                 190         


Ala Met Arg Leu Pro Phe Cys Gly Asn Asn Ile Ile Asn His Phe Ala 
        195                 200                 205             


Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile Ser Leu 
    210                 215                 220                 


Asn Ile Ile Thr Met Val Ile Ser Asn Met Ala Phe Leu Val Leu Pro 
225                 230                 235                 240 


Leu Met Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr Ile Leu 
                245                 250                 255     


Gln Met Asn Ser Ala Thr Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser 
            260                 265                 270         


Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe Phe Met 
        275                 280                 285             


Tyr Ala Lys Pro Lys Ser Gln Asp Leu Ile Gly Glu Glu Lys Leu Gln 
    290                 295                 300                 


Ala Leu Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr Pro Met 
305                 310                 315                 320 


Leu Asn Pro Ile Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala 
                325                 330                 335     


Val Lys Tyr Leu Leu Asn Lys Lys Pro Ile His 
            340                 345         


<210>  2410
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  2410
atggaaagga ccaacgattc cacgtcgaca gaatttttcc tggtagggct ttctgcccac     60

ccaaagctcc agacagtttt cttcgttcta attttgtgga tgtacctgat gatcctgctt    120

ggaaatggag tccttatctc agttatcatc tttgattctc acctgcacac ccccatgtat    180

ttcttcctct gtaatctttc cttcctcgac gtttgctaca caagttcctc tgtcccacta    240

attcttgcca gctttctggc agtaaagaaa aaggtttcct tctctgggtg tatggtgcaa    300

atgtttattt cttttgccat gggggccacg gagtgcatga tcttaggcac gatggcactg    360

gaccgctatg tggccatctg ctacccactg agataccctg tcatcatgag caagggtgcc    420

tatgtggcca tggcagctgg gtcctgggtc actgggcttg tggactcagt agtgcagaca    480

gcttttgcaa tgcagttacc attctgtgct aataatgtca ttaaacattt tgtctgtgaa    540

attctggcta tcttgaaact ggcctgtgct gatatttcaa tcaatgtgat tagtatgaca    600

gggtcgaatc tgattgttct ggttattcca ttgttagtaa tttccatctc ttacatattt    660

attgttgcca ctattctgag gattccttcc actgaaggaa aacataaggc cttctccacc    720

tgctcagccc acctgacagt ggtgattata ttctatggaa ccatcttctt catgtacgca    780

aagcctgagt ctaaagcctc tgttgattca ggtaatgaag acatcattga ggccctcatc    840

tcccttttct atggagtgat gactcccatg cttaatcctc tcatctatag tctgcgaaac    900

aaggatgtaa aggctgctgt caaaaacata ctgtgtagga aaaacttttc tgatggaaaa    960

tga                                                                  963


<210>  2411
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  2411

Met Glu Arg Thr Asn Asp Ser Thr Ser Thr Glu Phe Phe Leu Val Gly 
1               5                   10                  15      


Leu Ser Ala His Pro Lys Leu Gln Thr Val Phe Phe Val Leu Ile Leu 
            20                  25                  30          


Trp Met Tyr Leu Met Ile Leu Leu Gly Asn Gly Val Leu Ile Ser Val 
        35                  40                  45              


Ile Ile Phe Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Cys 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Val Cys Tyr Thr Ser Ser Ser Val Pro Leu 
65                  70                  75                  80  


Ile Leu Ala Ser Phe Leu Ala Val Lys Lys Lys Val Ser Phe Ser Gly 
                85                  90                  95      


Cys Met Val Gln Met Phe Ile Ser Phe Ala Met Gly Ala Thr Glu Cys 
            100                 105                 110         


Met Ile Leu Gly Thr Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Tyr 
        115                 120                 125             


Pro Leu Arg Tyr Pro Val Ile Met Ser Lys Gly Ala Tyr Val Ala Met 
    130                 135                 140                 


Ala Ala Gly Ser Trp Val Thr Gly Leu Val Asp Ser Val Val Gln Thr 
145                 150                 155                 160 


Ala Phe Ala Met Gln Leu Pro Phe Cys Ala Asn Asn Val Ile Lys His 
                165                 170                 175     


Phe Val Cys Glu Ile Leu Ala Ile Leu Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Ile Asn Val Ile Ser Met Thr Gly Ser Asn Leu Ile Val Leu Val 
        195                 200                 205             


Ile Pro Leu Leu Val Ile Ser Ile Ser Tyr Ile Phe Ile Val Ala Thr 
    210                 215                 220                 


Ile Leu Arg Ile Pro Ser Thr Glu Gly Lys His Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe 
                245                 250                 255     


Phe Met Tyr Ala Lys Pro Glu Ser Lys Ala Ser Val Asp Ser Gly Asn 
            260                 265                 270         


Glu Asp Ile Ile Glu Ala Leu Ile Ser Leu Phe Tyr Gly Val Met Thr 
        275                 280                 285             


Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Ala Ala Val Lys Asn Ile Leu Cys Arg Lys Asn Phe Ser Asp Gly Lys 
305                 310                 315                 320 


<210>  2412
<211>  957
<212>  DNA
<213>  Homosapiens

<400>  2412
atggaatggg aaaaccacac cattctggtg gaattttttc tgaagggact ttctggtcac     60

ccaagacttg agttactctt ttttgtgctc atcttcataa tgtatgtggt catccttctg    120

gggaatggta ctctcatttt aatcagcatc ttggaccctc accttcacac ccctatgtac    180

ttctttctgg ggaacctctc cttcttggac atctgctaca ccaccacctc tattccctcc    240

acgctagtga gcttcctttc agaaagaaag accatttccc tttctggctg tgcagtgcag    300

atgttcctca gcttggccat ggggacaaca gagtgtgtgc ttctgggcgt gatggccttt    360

gaccgctatg tggctatctg caaccctctg agatatccca tcatcatgag taaggatgcc    420

tatgtaccca tggcagctgg gtcctggatc ataggagctg tcaattctgc agtacaaaca    480

gtgtttgtgg tacaattgcc tttctgcagg aataacatca tcaatcattt cacctgtgaa    540

attctagctg tcatgaaact ggcctgtgct gacatctcag gcaatgagtt catcctgctt    600

gtgaccacaa cattgttcct attgacacct ttgttattaa ttattgtctc ttacacgtta    660

atcattttga gcatcttcaa aattagctct tcggagggga gaagcaaacc ttcctctacc    720

tgctcagctc gtctgactgt ggtgataaca ttctgtggga ccatcttcct catgtacatg    780

aagcccaagt ctcaagagac acttaattca gatgacttgg atgccactga caaacttata    840

ttcatattct acagggtgat gactcccatg atgaatcctt taatctacag tcttagaaac    900

aaggatgtga aggaggcagt aaaacaccta ctgagaagaa aaaattttaa caagtaa       957


<210>  2413
<211>  318
<212>  PRT
<213>  Homosapiens

<400>  2413

Met Glu Trp Glu Asn His Thr Ile Leu Val Glu Phe Phe Leu Lys Gly 
1               5                   10                  15      


Leu Ser Gly His Pro Arg Leu Glu Leu Leu Phe Phe Val Leu Ile Phe 
            20                  25                  30          


Ile Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile 
        35                  40                  45              


Ser Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser 
65                  70                  75                  80  


Thr Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Leu Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Phe Leu Ser Leu Ala Met Gly Thr Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Gly Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Ile Met Ser Lys Asp Ala Tyr Val Pro Met 
    130                 135                 140                 


Ala Ala Gly Ser Trp Ile Ile Gly Ala Val Asn Ser Ala Val Gln Thr 
145                 150                 155                 160 


Val Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Ile Ile Asn His 
                165                 170                 175     


Phe Thr Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Gly Asn Glu Phe Ile Leu Leu Val Thr Thr Thr Leu Phe Leu Leu 
        195                 200                 205             


Thr Pro Leu Leu Leu Ile Ile Val Ser Tyr Thr Leu Ile Ile Leu Ser 
    210                 215                 220                 


Ile Phe Lys Ile Ser Ser Ser Glu Gly Arg Ser Lys Pro Ser Ser Thr 
225                 230                 235                 240 


Cys Ser Ala Arg Leu Thr Val Val Ile Thr Phe Cys Gly Thr Ile Phe 
                245                 250                 255     


Leu Met Tyr Met Lys Pro Lys Ser Gln Glu Thr Leu Asn Ser Asp Asp 
            260                 265                 270         


Leu Asp Ala Thr Asp Lys Leu Ile Phe Ile Phe Tyr Arg Val Met Thr 
        275                 280                 285             


Pro Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Glu Ala Val Lys His Leu Leu Arg Arg Lys Asn Phe Asn Lys 
305                 310                 315             


<210>  2414
<211>  957
<212>  DNA
<213>  Homosapiens

<400>  2414
atggaatggg aaaaccacac cattctggtg gaattttttc tgaagggact ttctggtcac     60

ccaagacttg agttactctt ttttgtgctc atcttcataa tgtatgtggt catccttctg    120

gggaatggta ctctcatttt aatcagcatc ttggaccctc accttcacac ccctatgtac    180

ttctttctgg ggaacctctc cttcttggac atctgctaca ccaccacctc tattccctcc    240

acgctagtga gcttcctttc agaaagaaag accatttccc tttctggctg tgcagtgcag    300

atgttcctcg gcttggccat ggggacaaca gagtgtgtgc ttctgggcat gatggccttt    360

gaccgctatg tggctatctg caaccctctg agatatccca tcatcatgag taaggatgcc    420

tatgtaccca tggcagctgg gtcctggatc ataggagctg tcaattctgc agtacaatca    480

gtgtttgtgg tacaattgcc tttctgcagg aataacatca tcaatcattt cacctgtgaa    540

attctggctg tcatgaaact ggcctgtgct gacatctcag acaatgagtt catcatgctt    600

gtggccacaa cattgttcat attgacacct ttgttattaa tcattgtctc ttacacgtta    660

atcattgtga gcatcttcaa aattagctct tccgagggga gaagcaaagc ttcctctacc    720

tgttcagccc atctgactgt ggtcataata ttctatggga ccatcctctt catgtacatg    780

aagcccaagt ctaaagagac acttaattcg gatgacttgg atgctaccga caaaattata    840

tccatgttct atggggtgat gactcccatg atgaatcctt taatctacag tcttagaaac    900

aaggatgtga aagaggcagt aaaacaccta ctgaacagaa ggttctttag caagtga       957


<210>  2415
<211>  318
<212>  PRT
<213>  Homosapiens

<400>  2415

Met Glu Trp Glu Asn His Thr Ile Leu Val Glu Phe Phe Leu Lys Gly 
1               5                   10                  15      


Leu Ser Gly His Pro Arg Leu Glu Leu Leu Phe Phe Val Leu Ile Phe 
            20                  25                  30          


Ile Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile 
        35                  40                  45              


Ser Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser 
65                  70                  75                  80  


Thr Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Leu Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Phe Leu Gly Leu Ala Met Gly Thr Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Ile Met Ser Lys Asp Ala Tyr Val Pro Met 
    130                 135                 140                 


Ala Ala Gly Ser Trp Ile Ile Gly Ala Val Asn Ser Ala Val Gln Ser 
145                 150                 155                 160 


Val Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Ile Ile Asn His 
                165                 170                 175     


Phe Thr Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Asp Asn Glu Phe Ile Met Leu Val Ala Thr Thr Leu Phe Ile Leu 
        195                 200                 205             


Thr Pro Leu Leu Leu Ile Ile Val Ser Tyr Thr Leu Ile Ile Val Ser 
    210                 215                 220                 


Ile Phe Lys Ile Ser Ser Ser Glu Gly Arg Ser Lys Ala Ser Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu 
                245                 250                 255     


Phe Met Tyr Met Lys Pro Lys Ser Lys Glu Thr Leu Asn Ser Asp Asp 
            260                 265                 270         


Leu Asp Ala Thr Asp Lys Ile Ile Ser Met Phe Tyr Gly Val Met Thr 
        275                 280                 285             


Pro Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Glu Ala Val Lys His Leu Leu Asn Arg Arg Phe Phe Ser Lys 
305                 310                 315             


<210>  2416
<211>  957
<212>  DNA
<213>  Homosapiens

<400>  2416
atggaatggg aaaaccaaac cattctggtg gaattttttc tgaagggaca ttctgttcac     60

ccaaggcttg agttactctt ttttgtgcta atcttcataa tgtatgtggt catccttctg    120

gggaatggta ctctcatttt aatcagcatc ttggaccctc accttcacac ccctatgtac    180

ttctttctgg ggaacctctc cttcttggac atctgctaca ccaccacctc tattccctcc    240

acactagtga gcttcctttc agaaagaaag accatttcct tttctggctg tgcagtgcag    300

atgttccttg gcttggccat ggggacaaca gagtgtgtgc ttctgggcat gatggccttt    360

gaccgctatg tggctatctg caaccctctg agatatccca tcatcatgag caagaatgcc    420

tatgtaccca tggctgttgg gtcctggttt gcagggattg tcaactctgc agtacaaact    480

acatttgtag tacaattgcc tttctgcagg aagaatgtca tcaatcattt ctcatgtgaa    540

attctagctg tcatgaagtt ggcctgtgct gacatctcag gcaatgagtt cctcatgctt    600

gtggccacaa tattgttcac attgatgcca ctgctcttga tagttatctc ttactcatta    660

atcatttcca gcatcctcaa gattcactcc tctgagggga gaagcaaagc tttctctacc    720

tgctcagccc atctgactgt ggtcataata ttctatggga ccatcctctt catgtatatg    780

aagcccaagt ctaaagagac acttaattca gatgacttgg atgctaccga caaaattata    840

tccatgttct atggggtgat gactcccatg atgaatcctt taatctacag tcttagaaac    900

aaggatgtga aagaggcagt aaaacaccta ccgaacagaa ggttctttag caagtga       957


<210>  2417
<211>  318
<212>  PRT
<213>  Homosapiens

<400>  2417

Met Glu Trp Glu Asn Gln Thr Ile Leu Val Glu Phe Phe Leu Lys Gly 
1               5                   10                  15      


His Ser Val His Pro Arg Leu Glu Leu Leu Phe Phe Val Leu Ile Phe 
            20                  25                  30          


Ile Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile 
        35                  40                  45              


Ser Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser 
65                  70                  75                  80  


Thr Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Phe Leu Gly Leu Ala Met Gly Thr Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Ile Met Ser Lys Asn Ala Tyr Val Pro Met 
    130                 135                 140                 


Ala Val Gly Ser Trp Phe Ala Gly Ile Val Asn Ser Ala Val Gln Thr 
145                 150                 155                 160 


Thr Phe Val Val Gln Leu Pro Phe Cys Arg Lys Asn Val Ile Asn His 
                165                 170                 175     


Phe Ser Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Gly Asn Glu Phe Leu Met Leu Val Ala Thr Ile Leu Phe Thr Leu 
        195                 200                 205             


Met Pro Leu Leu Leu Ile Val Ile Ser Tyr Ser Leu Ile Ile Ser Ser 
    210                 215                 220                 


Ile Leu Lys Ile His Ser Ser Glu Gly Arg Ser Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu 
                245                 250                 255     


Phe Met Tyr Met Lys Pro Lys Ser Lys Glu Thr Leu Asn Ser Asp Asp 
            260                 265                 270         


Leu Asp Ala Thr Asp Lys Ile Ile Ser Met Phe Tyr Gly Val Met Thr 
        275                 280                 285             


Pro Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Glu Ala Val Lys His Leu Pro Asn Arg Arg Phe Phe Ser Lys 
305                 310                 315             


<210>  2418
<211>  1041
<212>  DNA
<213>  Homosapiens

<400>  2418
atgtacagat ttacagattt tgatgtatca aacatttcaa tttacctgaa tcatgtcctt     60

ttctatacta cccagcaggc aggtgaccta gaacacatgg agacaagaaa ttactctgcc    120

atgactgaat tctttctggt ggggctttcc caatatccag agctccagct ttttctgttc    180

ctgctctgcc tcatcatgta catgataatc ctcctgggaa atagcctcct cattatcatc    240

accatcttgg attctcgcct ccatactccc atgtatttct ttcttggaaa cctctcattc    300

ttggacatct gttacacatc ctcatccatt cctccaatgc ttattatatt tatgtctgag    360

agaaaatcca tctccttcat tggctgtgct ctgcagatgg ttgtgtccct tggcttgggc    420

tccactgagt gtgtcctcct ggctgtgatg gcctatgacc actatgtggc catctgcaac    480

ccactgaggt actccatcat catgaacgga gtgctgtatg tgcaaatggc tgcatggtcc    540

tggatcatag gctgtctgac ctccctattg caaacagttc tgacaatgat gttgcctttc    600

tgtgggaata atgtcattga tcatattacc tgtgaaattt tggcccttct aaaacttgtt    660

tgttcagata tcaccatcaa tgtgcttatc atgacagtga caaatattgt ttcactggtg    720

attcttctac tgttaatttt catctcctat gtgtttattc tctcttccat cctgagaatt    780

aattgtgctg agggaagaaa gaaagccttc tctacctgtt cagcgcactc gattgtggtc    840

atcttattct acggttcagc cctttttatg tacatgaaac ccaagtcaaa gaacactaat    900

acatctgatg agattattgg gctgtcttat ggagtggtaa gcccaatgtt aaatcccatc    960

atctatagcc tcaggaataa agaggtcaaa gaggctgtaa agaaagtcct gagcagacat   1020

ctgcatttat tgaaaatgtg a                                             1041


<210>  2419
<211>  346
<212>  PRT
<213>  Homosapiens

<400>  2419

Met Tyr Arg Phe Thr Asp Phe Asp Val Ser Asn Ile Ser Ile Tyr Leu 
1               5                   10                  15      


Asn His Val Leu Phe Tyr Thr Thr Gln Gln Ala Gly Asp Leu Glu His 
            20                  25                  30          


Met Glu Thr Arg Asn Tyr Ser Ala Met Thr Glu Phe Phe Leu Val Gly 
        35                  40                  45              


Leu Ser Gln Tyr Pro Glu Leu Gln Leu Phe Leu Phe Leu Leu Cys Leu 
    50                  55                  60                  


Ile Met Tyr Met Ile Ile Leu Leu Gly Asn Ser Leu Leu Ile Ile Ile 
65                  70                  75                  80  


Thr Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
                85                  90                  95      


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Ile Pro Pro 
            100                 105                 110         


Met Leu Ile Ile Phe Met Ser Glu Arg Lys Ser Ile Ser Phe Ile Gly 
        115                 120                 125             


Cys Ala Leu Gln Met Val Val Ser Leu Gly Leu Gly Ser Thr Glu Cys 
    130                 135                 140                 


Val Leu Leu Ala Val Met Ala Tyr Asp His Tyr Val Ala Ile Cys Asn 
145                 150                 155                 160 


Pro Leu Arg Tyr Ser Ile Ile Met Asn Gly Val Leu Tyr Val Gln Met 
                165                 170                 175     


Ala Ala Trp Ser Trp Ile Ile Gly Cys Leu Thr Ser Leu Leu Gln Thr 
            180                 185                 190         


Val Leu Thr Met Met Leu Pro Phe Cys Gly Asn Asn Val Ile Asp His 
        195                 200                 205             


Ile Thr Cys Glu Ile Leu Ala Leu Leu Lys Leu Val Cys Ser Asp Ile 
    210                 215                 220                 


Thr Ile Asn Val Leu Ile Met Thr Val Thr Asn Ile Val Ser Leu Val 
225                 230                 235                 240 


Ile Leu Leu Leu Leu Ile Phe Ile Ser Tyr Val Phe Ile Leu Ser Ser 
                245                 250                 255     


Ile Leu Arg Ile Asn Cys Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr 
            260                 265                 270         


Cys Ser Ala His Ser Ile Val Val Ile Leu Phe Tyr Gly Ser Ala Leu 
        275                 280                 285             


Phe Met Tyr Met Lys Pro Lys Ser Lys Asn Thr Asn Thr Ser Asp Glu 
    290                 295                 300                 


Ile Ile Gly Leu Ser Tyr Gly Val Val Ser Pro Met Leu Asn Pro Ile 
305                 310                 315                 320 


Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Val Lys Lys Val 
                325                 330                 335     


Leu Ser Arg His Leu His Leu Leu Lys Met 
            340                 345     


<210>  2420
<211>  1664
<212>  DNA
<213>  Homosapiens

<400>  2420
gcgtctgcca atgatccagg agccgctcct ttccactcgg gaaaccttca gaggagtctc     60

agaaaggaca cggctggctg cttttctcag cgccgaagcc gcgccatgct cgtcctcaga    120

agcgccctga ctcgggcgct ggcctcacgg acgctggcgc ctcagatgtg ctcatctttt    180

gctacgggac ccagacaata cgatggaata ttctatgaat ttcgttctta ttaccttaag    240

ccctcaaaga tgaatgagtt cctggaaaat tttgagaaaa acgctcatct tcggacagct    300

cactctgaat tggttggata ctggagtgta gaatttggag gcagaatgaa tacagtgttt    360

catatttgga agtatgataa ttttgctcat cgaactgaag ttcggaaagc cttggccaaa    420

gataaggaat ggcaagaaca attcctcatt ccaaatttgg ctctcattga taaacaagag    480

agtgagatta cttatctggt accatggtgc aaattagaaa aacctccaaa agaaggagtc    540

tatgaactgg ccacttttca gatgaaacct ggtgggccag ctctgtgggg tgatgcattt    600

aaaagggcag ttcatgctca tgtcaatcta ggctacacaa aactagttgg agtgttccac    660

acagagtacg gagcactcaa cagagttcat gttctttggt ggaatgagag tgcagatagt    720

cgtgcagctg ggagacataa gtcccatgag gatcccagag ttgtggcagc tgttcgggaa    780

agtgtcaact acctagtatc tcagcagaat atgcttctga ttcctacatc gttttcacca    840

ctgaaatagt tttctactga aatacaaaac atttcattaa ctgctatagg atctgtctgc    900

taatggtgct taaattctcc caagaggttc tcacttttat ttgaaggagg tgttaagtta    960

atttgctatg tttcttgcat tatgaaggct acatctgtgc tttgtaagta ccacttcaaa   1020

aaatagttct gtttactttc tgcatggtat ttcagtgtct gtcatacatt aaaaatactt   1080

gtcactgttt taagatcttg actcttcatt tgtttcagaa tagctcttct actgtattct   1140

gacaactctt tgctttatag cattttgttg tattcaaatg ataatggtag catttccatg   1200

cttgtgacag catttttaag ttattaatat attttatcaa cctttccatc atgtctgttt   1260

tcctggtttt ttttggttgt tttttgacca gtaaaattta ttttgtaata ccaaatagga   1320

tttaagaaaa ttaacgtatt tctttactat ggaaaaccac attgtcattt gtgacatcat   1380

ctatattaaa tatggttttc acattagtta tttgtcactt acttggaaaa tgatgctgtt   1440

aggtcctggt attaaaaatc tagaaaagac ttgttggttt atgtgctgaa atgtctttat   1500

ttataattaa ttttaactac tatttacttc atttcggatc ctgtttaaca aagatacttg   1560

agacatccat ttgttttaat gaaatctgta tggatatgga aatgcttgcc ctaataaaag   1620

cctacatata cctccaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                    1664


<210>  2421
<211>  247
<212>  PRT
<213>  Homosapiens

<400>  2421

Met Leu Val Leu Arg Ser Ala Leu Thr Arg Ala Leu Ala Ser Arg Thr 
1               5                   10                  15      


Leu Ala Pro Gln Met Cys Ser Ser Phe Ala Thr Gly Pro Arg Gln Tyr 
            20                  25                  30          


Asp Gly Ile Phe Tyr Glu Phe Arg Ser Tyr Tyr Leu Lys Pro Ser Lys 
        35                  40                  45              


Met Asn Glu Phe Leu Glu Asn Phe Glu Lys Asn Ala His Leu Arg Thr 
    50                  55                  60                  


Ala His Ser Glu Leu Val Gly Tyr Trp Ser Val Glu Phe Gly Gly Arg 
65                  70                  75                  80  


Met Asn Thr Val Phe His Ile Trp Lys Tyr Asp Asn Phe Ala His Arg 
                85                  90                  95      


Thr Glu Val Arg Lys Ala Leu Ala Lys Asp Lys Glu Trp Gln Glu Gln 
            100                 105                 110         


Phe Leu Ile Pro Asn Leu Ala Leu Ile Asp Lys Gln Glu Ser Glu Ile 
        115                 120                 125             


Thr Tyr Leu Val Pro Trp Cys Lys Leu Glu Lys Pro Pro Lys Glu Gly 
    130                 135                 140                 


Val Tyr Glu Leu Ala Thr Phe Gln Met Lys Pro Gly Gly Pro Ala Leu 
145                 150                 155                 160 


Trp Gly Asp Ala Phe Lys Arg Ala Val His Ala His Val Asn Leu Gly 
                165                 170                 175     


Tyr Thr Lys Leu Val Gly Val Phe His Thr Glu Tyr Gly Ala Leu Asn 
            180                 185                 190         


Arg Val His Val Leu Trp Trp Asn Glu Ser Ala Asp Ser Arg Ala Ala 
        195                 200                 205             


Gly Arg His Lys Ser His Glu Asp Pro Arg Val Val Ala Ala Val Arg 
    210                 215                 220                 


Glu Ser Val Asn Tyr Leu Val Ser Gln Gln Asn Met Leu Leu Ile Pro 
225                 230                 235                 240 


Thr Ser Phe Ser Pro Leu Lys 
                245         


<210>  2422
<211>  1781
<212>  DNA
<213>  Homosapiens

<400>  2422
actcgggaag acttcagaga agtctcacaa aggactcggc tggctgcttt tctcagtgcc     60

gaagccgcgc catgctcgtt ctcagaagcg gcctgaccaa ggcgcttgcc tcacggacgc    120

tcgcgcctca ggtgtgttca tcttttgcta cgggccctag acaatacgat ggaacgttct    180

atgaatttcg tacttattac cttaaacctt caaatatgaa tgcgttcatg gaaaatctta    240

agaaaaacat tcatcttcgg acctcttact ctgaattggt tggattctgg agtgtagaat    300

ttggaggcag aacgaataaa gtgtttcata tttggaagta tgataatttt gctcatcgag    360

ctgaagttcg gaaagcctta gccaactgta aggaatggca agaacaatct atcattccaa    420

atttggctcg cattgataaa caagagacgg aaattactta cctgatacca tggtccaaat    480

tagaaaagcc tccaaaagaa ggagtctatg aactagctgt ttttcagatg aaacctggtg    540

ggccagctct gtggggtgat gcatttgaaa gagcaattaa tgcccatgtc aatttaggct    600

acacaaaagt agttggtgtt ttccacacag aatatggaga actcaacaga gttcatgttc    660

tttggtggaa tgagagtgca gatagtcgtg cagctgggag acataagtcc catgaggatc    720

ccagagttgt ggcggctgtt cgggaaagtg tcaactacct agtttctcag cagaatatgc    780

ttctgattcc tgcatcattt tcaccattga aatagttttc tactgaaata caaaacattt    840

cattaactgc tctaagatgt gtctgctaat ggtgcttaaa ttctcccaag aggttctcgc    900

ttttatttga aggaggtggt aagttaatta gttaatttgc tgtgcttctt gcatttttga    960

aagttacata ttctccactg ctttaagaaa taattcagtt cactttcacc ttggcatttc   1020

agtatctgtt acacattaga agtagttgtc actatttcat catcttggtt tttcatttgt   1080

tttagaatac ctcttctgta ttttgataac tcattgcttt atagcatttt cttttactca   1140

aataaggatt ttacatttcc ttgcctgaca gtatttttga attatttata taaaatatct   1200

atcttttcat catgtctata gttcctgaga ttttaaaaaa atttgcttag taaaggttat   1260

tttgtgatat aaaatgggat ttataaaaat attagattgt ttatttcttt actgtggaaa   1320

agtagaatgt catctgtatt aattattgct tttacattca ttgattatta gtcattctaa   1380

cttggaaaat aatgcaattg ggtcacagtg ttaaaaatct agaaaagact tgttggttta   1440

tatgctgaaa ttgttcattt ataattaatt ttactaattt ctccttagtt tggatcacta   1500

acagagatct tgggacattt atttgtttta aagaaatatt tatggttatg gaaacgcttg   1560

ccctaataaa aatcctgcat attcattgtt tttttaaatt cacattttat acttatatga   1620

tctctaaagc tcttgctatg ttgctataag acagtaatat agtgataatt taccaacttt   1680

attgaaaatg ttgttacatc aataaaatag catgctggga acctgagaag gaaggtttct   1740

ttagtactgc caaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       1781


<210>  2423
<211>  247
<212>  PRT
<213>  Homosapiens

<400>  2423

Met Leu Val Leu Arg Ser Gly Leu Thr Lys Ala Leu Ala Ser Arg Thr 
1               5                   10                  15      


Leu Ala Pro Gln Val Cys Ser Ser Phe Ala Thr Gly Pro Arg Gln Tyr 
            20                  25                  30          


Asp Gly Thr Phe Tyr Glu Phe Arg Thr Tyr Tyr Leu Lys Pro Ser Asn 
        35                  40                  45              


Met Asn Ala Phe Met Glu Asn Leu Lys Lys Asn Ile His Leu Arg Thr 
    50                  55                  60                  


Ser Tyr Ser Glu Leu Val Gly Phe Trp Ser Val Glu Phe Gly Gly Arg 
65                  70                  75                  80  


Thr Asn Lys Val Phe His Ile Trp Lys Tyr Asp Asn Phe Ala His Arg 
                85                  90                  95      


Ala Glu Val Arg Lys Ala Leu Ala Asn Cys Lys Glu Trp Gln Glu Gln 
            100                 105                 110         


Ser Ile Ile Pro Asn Leu Ala Arg Ile Asp Lys Gln Glu Thr Glu Ile 
        115                 120                 125             


Thr Tyr Leu Ile Pro Trp Ser Lys Leu Glu Lys Pro Pro Lys Glu Gly 
    130                 135                 140                 


Val Tyr Glu Leu Ala Val Phe Gln Met Lys Pro Gly Gly Pro Ala Leu 
145                 150                 155                 160 


Trp Gly Asp Ala Phe Glu Arg Ala Ile Asn Ala His Val Asn Leu Gly 
                165                 170                 175     


Tyr Thr Lys Val Val Gly Val Phe His Thr Glu Tyr Gly Glu Leu Asn 
            180                 185                 190         


Arg Val His Val Leu Trp Trp Asn Glu Ser Ala Asp Ser Arg Ala Ala 
        195                 200                 205             


Gly Arg His Lys Ser His Glu Asp Pro Arg Val Val Ala Ala Val Arg 
    210                 215                 220                 


Glu Ser Val Asn Tyr Leu Val Ser Gln Gln Asn Met Leu Leu Ile Pro 
225                 230                 235                 240 


Ala Ser Phe Ser Pro Leu Lys 
                245         


<210>  2424
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  2424
gtaattgcga gcgagagtga gtggggccgg gacccgcaga gccgagccga cccttctctc     60

ccgggctgcg gcagggcagg gcggggagct ccgcgcacca acagagccgg ttctcagggc    120

gctttgctcc ttgttttttc cccggttctg ttttctcccc ttctccggaa ggcttgtcaa    180

ggggtaggag aaagagacgc aaacacaaaa gtggaaaaca gttaatgacc agccacggcg    240

tccctgctgt gagctctggc cgctgccttc cagggctccc gagccacacg ctgggggtgc    300

tggctgaggg aacatggctt gttggcctca gctgaggttg ctgctgtgga agaacctcac    360

tttcagaaga agacaaacat gtcagctgct gctggaagtg gcctggcctc tatttatctt    420

cctgatcctg atctctgttc ggctgagcta cccaccctat gaacaacatg aatgccattt    480

tccaaataaa gccatgccct ctgcaggaac acttccttgg gttcagggga ttatctgtaa    540

tgccaacaac ccctgtttcc gttacccgac tcctggggag gctcccggag ttgttggaaa    600

ctttaacaaa tccattgtgg ctcgcctgtt ctcagatgct cggaggcttc ttttatacag    660

ccagaaagac accagcatga aggacatgcg caaagttctg agaacattac agcagatcaa    720

gaaatccagc tcaaacttga agcttcaaga tttcctggtg gacaatgaaa ccttctctgg    780

gttcctgtat cacaacctct ctctcccaaa gtctactgtg gacaagatgc tgagggctga    840

tgtcattctc cacaaggtat ttttgcaagg ctaccagtta catttgacaa gtctgtgcaa    900

tggatcaaaa tcagaagaga tgattcaact tggtgaccaa gaagtttctg agctttgtgg    960

cctaccaagg gagaaactgg ctgcagcaga gcgagtactt cgttccaaca tggacatcct   1020

gaagccaatc ctgagaacac taaactctac atctcccttc ccgagcaagg agctggctga   1080

agccacaaaa acattgctgc atagtcttgg gactctggcc caggagctgt tcagcatgag   1140

aagctggagt gacatgcgac aggaggtgat gtttctgacc aatgtgaaca gctccagctc   1200

ctccacccaa atctaccagg ctgtgtctcg tattgtctgc gggcatcccg agggaggggg   1260

gctgaagatc aagtctctca actggtatga ggacaacaac tacaaagccc tctttggagg   1320

caatggcact gaggaagatg ctgaaacctt ctatgacaac tctacaactc cttactgcaa   1380

tgatttgatg aagaatttgg agtctagtcc tctttcccgc attatctgga aagctctgaa   1440

gccgctgctc gttgggaaga tcctgtatac acctgacact ccagccacaa ggcaggtcat   1500

ggctgaggtg aacaagacct tccaggaact ggctgtgttc catgatctgg aaggcatgtg   1560

ggaggaactc agccccaaga tctggacctt catggagaac agccaagaaa tggaccttgt   1620

ccggatgctg ttggacagca gggacaatga ccacttttgg gaacagcagt tggatggctt   1680

agattggaca gcccaagaca tcgtggcgtt tttggccaag cacccagagg atgtccagtc   1740

cagtaatggt tctgtgtaca cctggagaga agctttcaac gagactaacc aggcaatccg   1800

gaccatatct cgcttcatgg agtgtgtcaa cctgaacaag ctagaaccca tagcaacaga   1860

agtctggctc atcaacaagt ccatggagct gctggatgag aggaagttct gggctggtat   1920

tgtgttcact ggaattactc caggcagcat tgagctgccc catcatgtca agtacaagat   1980

ccgaatggac attgacaatg tggagaggac aaataaaatc aaggatgggt actgggaccc   2040

tggtcctcga gctgacccct ttgaggacat gcggtacgtc tgggggggct tcgcctactt   2100

gcaggatgtg gtggagcagg caatcatcag ggtgctgacg ggcaccgaga agaaaactgg   2160

tgtctatatg caacagatgc cctatccctg ttacgttgat gacatctttc tgcgggtgat   2220

gagccggtca atgcccctct tcatgacgct ggcctggatt tactcagtgg ctgtgatcat   2280

caagggcatc gtgtatgaga aggaggcacg gctgaaagag accatgcgga tcatgggcct   2340

ggacaacagc atcctctggt ttagctggtt cattagtagc ctcattcctc ttcttgtgag   2400

cgctggcctg ctagtggtca tcctgaagtt aggaaacctg ctgccctaca gtgatcccag   2460

cgtggtgttt gtcttcctgt ccgtgtttgc tgtggtgaca atcctgcagt gcttcctgat   2520

tagcacactc ttctccagag ccaacctggc agcagcctgt gggggcatca tctacttcac   2580

gctgtacctg ccctacgtcc tgtgtgtggc atggcaggac tacgtgggct tcacactcaa   2640

gatcttcgct agcctgctgt ctcctgtggc ttttgggttt ggctgtgagt actttgccct   2700

ttttgaggag cagggcattg gagtgcagtg ggacaacctg tttgagagtc ctgtggagga   2760

agatggcttc aatctcacca cttcggtctc catgatgctg tttgacacct tcctctatgg   2820

ggtgatgacc tggtacattg aggctgtctt tccaggccag tacggaattc ccaggccctg   2880

gtattttcct tgcaccaagt cctactggtt tggcgaggaa agtgatgaga agagccaccc   2940

tggttccaac cagaagagaa tatcagaaat ctgcatggag gaggaaccca cccacttgaa   3000

gctgggcgtg tccattcaga acctggtaaa agtctaccga gatgggatga aggtggctgt   3060

cgatggcctg gcactgaatt tttatgaggg ccagatcacc tccttcctgg gccacaatgg   3120

agcggggaag acgaccacca tgtcaatcct gaccgggttg ttccccccga cctcgggcac   3180

cgcctacatc ctgggaaaag acattcgctc tgagatgagc accatccggc agaacctggg   3240

ggtctgtccc cagcataacg tgctgtttga catgctgact gtcgaagaac acatctggtt   3300

ctatgcccgc ttgaaagggc tctctgagaa gcacgtgaag gcggagatgg agcagatggc   3360

cctggatgtt ggtttgccat caagcaagct gaaaagcaaa acaagccagc tgtcaggtgg   3420

aatgcagaga aagctatctg tggccttggc ctttgtcggg ggatctaagg ttgtcattct   3480

ggatgaaccc acagctggtg tggaccctta ctcccgcagg ggaatatggg agctgctgct   3540

gaaataccga caaggccgca ccattattct ctctacacac cacatggatg aagcggacgt   3600

cctgggggac aggattgcca tcatctccca tgggaagctg tgctgtgtgg gctcctccct   3660

gtttctgaag aaccagctgg gaacaggcta ctacctgacc ttggtcaaga aagatgtgga   3720

atcctccctc agttcctgca gaaacagtag tagcactgtg tcatacctga aaaaggagga   3780

cagtgtttct cagagcagtt ctgatgctgg cctgggcagc gaccatgaga gtgacacgct   3840

gaccatcgat gtctctgcta tctccaacct catcaggaag catgtgtctg aagcccggct   3900

ggtggaagac atagggcatg agctgaccta tgtgctgcca tatgaagctg ctaaggaggg   3960

agcctttgtg gaactctttc atgagattga tgaccggctc tcagacctgg gcatttctag   4020

ttatggcatc tcagagacga ccctggaaga aatattcctc aaggtggccg aagagagtgg   4080

ggtggatgct gagacctcag atggtacctt gccagcaaga cgaaacaggc gggccttcgg   4140

ggacaagcag agctgtcttc gcccgttcac tgaagatgat gctgctgatc caaatgattc   4200

tgacatagac ccagaatcca gagagacaga cttgctcagt gggatggatg gcaaagggtc   4260

ctaccaggtg aaaggctgga aacttacaca gcaacagttt gtggcccttt tgtggaagag   4320

actgctaatt gccagacgga gtcggaaagg attttttgct cagattgtct tgccagctgt   4380

gtttgtctgc attgcccttg tgttcagcct gatcgtgcca ccctttggca agtaccccag   4440

cctggaactt cagccctgga tgtacaacga acagtacaca tttgtcagca atgatgctcc   4500

tgaggacacg ggaaccctgg aactcttaaa cgccctcacc aaagaccctg gcttcgggac   4560

ccgctgtatg gaaggaaacc caatcccaga cacgccctgc caggcagggg aggaagagtg   4620

gaccactgcc ccagttcccc agaccatcat ggacctcttc cagaatggga actggacaat   4680

gcagaaccct tcacctgcat gccagtgtag cagcgacaaa atcaagaaga tgctgcctgt   4740

gtgtccccca ggggcagggg ggctgcctcc tccacaaaga aaacaaaaca ctgcagatat   4800

ccttcaggac ctgacaggaa gaaacatttc ggattatctg gtgaagacgt atgtgcagat   4860

catagccaaa agcttaaaga acaagatctg ggtgaatgag tttaggtatg gcggcttttc   4920

cctgggtgtc agtaatactc aagcacttcc tccgagtcaa gaagttaatg atgccatcaa   4980

acaaatgaag aaacacctaa agctggccaa ggacagttct gcagatcgat ttctcaacag   5040

cttgggaaga tttatgacag gactggacac caaaaataat gtcaaggtgt ggttcaataa   5100

caagggctgg catgcaatca gctctttcct gaatgtcatc aacaatgcca ttctccgggc   5160

caacctgcaa aagggagaga accctagcca ttatggaatt actgctttca atcatcccct   5220

gaatctcacc aagcagcagc tctcagaggt ggctctgatg accacatcag tggatgtcct   5280

tgtgtccatc tgtgtcatct ttgcaatgtc cttcgtccca gccagctttg tcgtattcct   5340

gatccaggag cgggtcagca aagcaaaaca cctgcagttc atcagtggag tgaagcctgt   5400

catctactgg ctctctaatt ttgtctggga tatgtgcaat tacgttgtcc ctgccacact   5460

ggtcattatc atcttcatct gcttccagca gaagtcctat gtgtcctcca ccaatctgcc   5520

tgtgctagcc cttctacttt tgctgtatgg gtggtcaatc acacctctca tgtacccagc   5580

ctcctttgtg ttcaagatcc ccagcacagc ctatgtggtg ctcaccagcg tgaacctctt   5640

cattggcatt aatggcagcg tggccacctt tgtgctggag ctgttcaccg acaataagct   5700

gaataatatc aatgatatcc tgaagtccgt gttcttgatc ttcccacatt tttgcctggg   5760

acgagggctc atcgacatgg tgaaaaacca ggcaatggct gatgccctgg aaaggtttgg   5820

ggagaatcgc tttgtgtcac cattatcttg ggacttggtg ggacgaaacc tcttcgccat   5880

ggccgtggaa ggggtggtgt tcttcctcat tactgttctg atccagtaca gattcttcat   5940

caggcccaga cctgtaaatg caaagctatc tcctctgaat gatgaagatg aagatgtgag   6000

gcgggaaaga cagagaattc ttgatggtgg aggccagaat gacatcttag aaatcaagga   6060

gttgacgaag atatatagaa ggaagcggaa gcctgctgtt gacaggattt gcgtgggcat   6120

tcctcctggt gagtgctttg ggctcctggg agttaatggg gctggaaaat catcaacttt   6180

caagatgtta acaggagata ccactgttac cagaggagat gctttcctta acaaaaatag   6240

tatcttatca aacatccatg aagtacatca gaacatgggc tactgccctc agtttgatgc   6300

catcacagag ctgttgactg ggagagaaca cgtggagttc tttgcccttt tgagaggagt   6360

cccagagaaa gaagttggca aggttggtga gtgggcgatt cggaaactgg gcctcgtgaa   6420

gtatggagaa aaatatgctg gtaactatag tggaggcaac aaacgcaagc tctctacagc   6480

catggctttg atcggcgggc ctcctgtggt gtttctggat gaacccacca caggcatgga   6540

tcccaaagcc cggcggttct tgtggaattg tgccctaagt gttgtcaagg aggggagatc   6600

agtagtgctt acatctcata gtatggaaga atgtgaagct ctttgcacta ggatggcaat   6660

catggtcaat ggaaggttca ggtgccttgg cagtgtccag catctaaaaa ataggtttgg   6720

agatggttat acaatagttg tacgaatagc agggtccaac ccggacctga agcctgtcca   6780

ggatttcttt ggacttgcat ttcctggaag tgttctaaaa gagaaacacc ggaacatgct   6840

acaataccag cttccatctt cattatcttc tctggccagg atattcagca tcctctccca   6900

gagcaaaaag cgactccaca tagaagacta ctctgtttct cagacaacac ttgaccaagt   6960

atttgtgaac tttgccaagg accaaagtga tgatgaccac ttaaaagacc tctcattaca   7020

caaaaaccag acagtagtgg acgttgcagt tctcacatct tttctacagg atgagaaagt   7080

gaaagaaagc tatgtatgaa gaatcctgtt catacggggt ggctgaaagt aaagaggaac   7140

tagactttcc tttgcaccat gtgaagtgtt gtggagaaaa gagccagaag ttgatgtggg   7200

aagaagtaaa ctggatactg tactgatact attcaatgca atgcaattca atgcaatgaa   7260

aacaaaattc cattacaggg gcagtgcctt tgtagcctat gtcttgtatg gctctcaagt   7320

gaaagacttg aatttagttt tttacctata cctatgtgaa actctattat ggaacccaat   7380

ggacatatgg gtttgaactc acactttttt tttttttttt gttcctgtgt attctcattg   7440

gggttgcaac aataattcat caagtaatca tggccagcga ttattgatca aaatcaaaag   7500

gtaatgcaca tcctcattca ctaagccatg ccatgcccag gagactggtt tcccggtgac   7560

acatccattg ctggcaatga gtgtgccaga gttattagtg ccaagttttt cagaaagttt   7620

gaagcaccat ggtgtgtcat gctcactttt gtgaaagctg ctctgctcag agtctatcaa   7680

cattgaatat cagttgacag aatggtgcca tgcgtggcta acatcctgct ttgattccct   7740

ctgataagct gttctggtgg cagtaacatg caacaaaaat gtgggtgtct ccaggcacgg   7800

gaaacttggt tccattgtta tattgtccta tgcttcgagc catgggtcta cagggtcatc   7860

cttatgagac tcttaaatat acttagatcc tggtaagagg caaagaatca acagccaaac   7920

tgctggggct gcaagctgct gaagccaggg catgggatta aagagattgt gcgttcaaac   7980

ctagggaagc ctgtgcccat ttgtcctgac tgtctgctaa catggtacac tgcatctcaa   8040

gatgtttatc tgacacaagt gtattatttc tggctttttg aattaatcta gaaaatgaaa   8100

agatggagtt gtattttgac aaaaatgttt gtacttttta atgttatttg gaattttaag   8160

ttctatcagt gacttctgaa tccttagaat gg                                 8192


<210>  2425
<211>  2261
<212>  PRT
<213>  Homosapiens

<400>  2425

Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Thr 
1               5                   10                  15      


Phe Arg Arg Arg Gln Thr Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          


Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              


Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Thr Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Arg Tyr Pro Thr Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      


Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         


Leu Leu Tyr Ser Gln Lys Asp Thr Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             


Leu Arg Thr Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 


Gln Asp Phe Leu Val Asp Asn Glu Thr Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 


Asn Leu Ser Leu Pro Lys Ser Thr Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     


Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Thr 
            180                 185                 190         


Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             


Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 


Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 


Arg Thr Leu Asn Ser Thr Ser Pro Phe Pro Ser Lys Glu Leu Ala Glu 
                245                 250                 255     


Ala Thr Lys Thr Leu Leu His Ser Leu Gly Thr Leu Ala Gln Glu Leu 
            260                 265                 270         


Phe Ser Met Arg Ser Trp Ser Asp Met Arg Gln Glu Val Met Phe Leu 
        275                 280                 285             


Thr Asn Val Asn Ser Ser Ser Ser Ser Thr Gln Ile Tyr Gln Ala Val 
    290                 295                 300                 


Ser Arg Ile Val Cys Gly His Pro Glu Gly Gly Gly Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Leu Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Leu Phe Gly Gly 
                325                 330                 335     


Asn Gly Thr Glu Glu Asp Ala Glu Thr Phe Tyr Asp Asn Ser Thr Thr 
            340                 345                 350         


Pro Tyr Cys Asn Asp Leu Met Lys Asn Leu Glu Ser Ser Pro Leu Ser 
        355                 360                 365             


Arg Ile Ile Trp Lys Ala Leu Lys Pro Leu Leu Val Gly Lys Ile Leu 
    370                 375                 380                 


Tyr Thr Pro Asp Thr Pro Ala Thr Arg Gln Val Met Ala Glu Val Asn 
385                 390                 395                 400 


Lys Thr Phe Gln Glu Leu Ala Val Phe His Asp Leu Glu Gly Met Trp 
                405                 410                 415     


Glu Glu Leu Ser Pro Lys Ile Trp Thr Phe Met Glu Asn Ser Gln Glu 
            420                 425                 430         


Met Asp Leu Val Arg Met Leu Leu Asp Ser Arg Asp Asn Asp His Phe 
        435                 440                 445             


Trp Glu Gln Gln Leu Asp Gly Leu Asp Trp Thr Ala Gln Asp Ile Val 
    450                 455                 460                 


Ala Phe Leu Ala Lys His Pro Glu Asp Val Gln Ser Ser Asn Gly Ser 
465                 470                 475                 480 


Val Tyr Thr Trp Arg Glu Ala Phe Asn Glu Thr Asn Gln Ala Ile Arg 
                485                 490                 495     


Thr Ile Ser Arg Phe Met Glu Cys Val Asn Leu Asn Lys Leu Glu Pro 
            500                 505                 510         


Ile Ala Thr Glu Val Trp Leu Ile Asn Lys Ser Met Glu Leu Leu Asp 
        515                 520                 525             


Glu Arg Lys Phe Trp Ala Gly Ile Val Phe Thr Gly Ile Thr Pro Gly 
    530                 535                 540                 


Ser Ile Glu Leu Pro His His Val Lys Tyr Lys Ile Arg Met Asp Ile 
545                 550                 555                 560 


Asp Asn Val Glu Arg Thr Asn Lys Ile Lys Asp Gly Tyr Trp Asp Pro 
                565                 570                 575     


Gly Pro Arg Ala Asp Pro Phe Glu Asp Met Arg Tyr Val Trp Gly Gly 
            580                 585                 590         


Phe Ala Tyr Leu Gln Asp Val Val Glu Gln Ala Ile Ile Arg Val Leu 
        595                 600                 605             


Thr Gly Thr Glu Lys Lys Thr Gly Val Tyr Met Gln Gln Met Pro Tyr 
    610                 615                 620                 


Pro Cys Tyr Val Asp Asp Ile Phe Leu Arg Val Met Ser Arg Ser Met 
625                 630                 635                 640 


Pro Leu Phe Met Thr Leu Ala Trp Ile Tyr Ser Val Ala Val Ile Ile 
                645                 650                 655     


Lys Gly Ile Val Tyr Glu Lys Glu Ala Arg Leu Lys Glu Thr Met Arg 
            660                 665                 670         


Ile Met Gly Leu Asp Asn Ser Ile Leu Trp Phe Ser Trp Phe Ile Ser 
        675                 680                 685             


Ser Leu Ile Pro Leu Leu Val Ser Ala Gly Leu Leu Val Val Ile Leu 
    690                 695                 700                 


Lys Leu Gly Asn Leu Leu Pro Tyr Ser Asp Pro Ser Val Val Phe Val 
705                 710                 715                 720 


Phe Leu Ser Val Phe Ala Val Val Thr Ile Leu Gln Cys Phe Leu Ile 
                725                 730                 735     


Ser Thr Leu Phe Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Ile 
            740                 745                 750         


Ile Tyr Phe Thr Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Gln 
        755                 760                 765             


Asp Tyr Val Gly Phe Thr Leu Lys Ile Phe Ala Ser Leu Leu Ser Pro 
    770                 775                 780                 


Val Ala Phe Gly Phe Gly Cys Glu Tyr Phe Ala Leu Phe Glu Glu Gln 
785                 790                 795                 800 


Gly Ile Gly Val Gln Trp Asp Asn Leu Phe Glu Ser Pro Val Glu Glu 
                805                 810                 815     


Asp Gly Phe Asn Leu Thr Thr Ser Val Ser Met Met Leu Phe Asp Thr 
            820                 825                 830         


Phe Leu Tyr Gly Val Met Thr Trp Tyr Ile Glu Ala Val Phe Pro Gly 
        835                 840                 845             


Gln Tyr Gly Ile Pro Arg Pro Trp Tyr Phe Pro Cys Thr Lys Ser Tyr 
    850                 855                 860                 


Trp Phe Gly Glu Glu Ser Asp Glu Lys Ser His Pro Gly Ser Asn Gln 
865                 870                 875                 880 


Lys Arg Ile Ser Glu Ile Cys Met Glu Glu Glu Pro Thr His Leu Lys 
                885                 890                 895     


Leu Gly Val Ser Ile Gln Asn Leu Val Lys Val Tyr Arg Asp Gly Met 
            900                 905                 910         


Lys Val Ala Val Asp Gly Leu Ala Leu Asn Phe Tyr Glu Gly Gln Ile 
        915                 920                 925             


Thr Ser Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser 
    930                 935                 940                 


Ile Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Thr Ala Tyr Ile Leu 
945                 950                 955                 960 


Gly Lys Asp Ile Arg Ser Glu Met Ser Thr Ile Arg Gln Asn Leu Gly 
                965                 970                 975     


Val Cys Pro Gln His Asn Val Leu Phe Asp Met Leu Thr Val Glu Glu 
            980                 985                 990         


His Ile Trp Phe Tyr Ala Arg Leu  Lys Gly Leu Ser Glu  Lys His Val 
        995                 1000                 1005             


Lys Ala  Glu Met Glu Gln Met  Ala Leu Asp Val Gly  Leu Pro Ser 
    1010                 1015                 1020             


Ser Lys  Leu Lys Ser Lys Thr  Ser Gln Leu Ser Gly  Gly Met Gln 
    1025                 1030                 1035             


Arg Lys  Leu Ser Val Ala Leu  Ala Phe Val Gly Gly  Ser Lys Val 
    1040                 1045                 1050             


Val Ile  Leu Asp Glu Pro Thr  Ala Gly Val Asp Pro  Tyr Ser Arg 
    1055                 1060                 1065             


Arg Gly  Ile Trp Glu Leu Leu  Leu Lys Tyr Arg Gln  Gly Arg Thr 
    1070                 1075                 1080             


Ile Ile  Leu Ser Thr His His  Met Asp Glu Ala Asp  Val Leu Gly 
    1085                 1090                 1095             


Asp Arg  Ile Ala Ile Ile Ser  His Gly Lys Leu Cys  Cys Val Gly 
    1100                 1105                 1110             


Ser Ser  Leu Phe Leu Lys Asn  Gln Leu Gly Thr Gly  Tyr Tyr Leu 
    1115                 1120                 1125             


Thr Leu  Val Lys Lys Asp Val  Glu Ser Ser Leu Ser  Ser Cys Arg 
    1130                 1135                 1140             


Asn Ser  Ser Ser Thr Val Ser  Tyr Leu Lys Lys Glu  Asp Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser Ser Asp Ala  Gly Leu Gly Ser Asp  His Glu Ser 
    1160                 1165                 1170             


Asp Thr  Leu Thr Ile Asp Val  Ser Ala Ile Ser Asn  Leu Ile Arg 
    1175                 1180                 1185             


Lys His  Val Ser Glu Ala Arg  Leu Val Glu Asp Ile  Gly His Glu 
    1190                 1195                 1200             


Leu Thr  Tyr Val Leu Pro Tyr  Glu Ala Ala Lys Glu  Gly Ala Phe 
    1205                 1210                 1215             


Val Glu  Leu Phe His Glu Ile  Asp Asp Arg Leu Ser  Asp Leu Gly 
    1220                 1225                 1230             


Ile Ser  Ser Tyr Gly Ile Ser  Glu Thr Thr Leu Glu  Glu Ile Phe 
    1235                 1240                 1245             


Leu Lys  Val Ala Glu Glu Ser  Gly Val Asp Ala Glu  Thr Ser Asp 
    1250                 1255                 1260             


Gly Thr  Leu Pro Ala Arg Arg  Asn Arg Arg Ala Phe  Gly Asp Lys 
    1265                 1270                 1275             


Gln Ser  Cys Leu Arg Pro Phe  Thr Glu Asp Asp Ala  Ala Asp Pro 
    1280                 1285                 1290             


Asn Asp  Ser Asp Ile Asp Pro  Glu Ser Arg Glu Thr  Asp Leu Leu 
    1295                 1300                 1305             


Ser Gly  Met Asp Gly Lys Gly  Ser Tyr Gln Val Lys  Gly Trp Lys 
    1310                 1315                 1320             


Leu Thr  Gln Gln Gln Phe Val  Ala Leu Leu Trp Lys  Arg Leu Leu 
    1325                 1330                 1335             


Ile Ala  Arg Arg Ser Arg Lys  Gly Phe Phe Ala Gln  Ile Val Leu 
    1340                 1345                 1350             


Pro Ala  Val Phe Val Cys Ile  Ala Leu Val Phe Ser  Leu Ile Val 
    1355                 1360                 1365             


Pro Pro  Phe Gly Lys Tyr Pro  Ser Leu Glu Leu Gln  Pro Trp Met 
    1370                 1375                 1380             


Tyr Asn  Glu Gln Tyr Thr Phe  Val Ser Asn Asp Ala  Pro Glu Asp 
    1385                 1390                 1395             


Thr Gly  Thr Leu Glu Leu Leu  Asn Ala Leu Thr Lys  Asp Pro Gly 
    1400                 1405                 1410             


Phe Gly  Thr Arg Cys Met Glu  Gly Asn Pro Ile Pro  Asp Thr Pro 
    1415                 1420                 1425             


Cys Gln  Ala Gly Glu Glu Glu  Trp Thr Thr Ala Pro  Val Pro Gln 
    1430                 1435                 1440             


Thr Ile  Met Asp Leu Phe Gln  Asn Gly Asn Trp Thr  Met Gln Asn 
    1445                 1450                 1455             


Pro Ser  Pro Ala Cys Gln Cys  Ser Ser Asp Lys Ile  Lys Lys Met 
    1460                 1465                 1470             


Leu Pro  Val Cys Pro Pro Gly  Ala Gly Gly Leu Pro  Pro Pro Gln 
    1475                 1480                 1485             


Arg Lys  Gln Asn Thr Ala Asp  Ile Leu Gln Asp Leu  Thr Gly Arg 
    1490                 1495                 1500             


Asn Ile  Ser Asp Tyr Leu Val  Lys Thr Tyr Val Gln  Ile Ile Ala 
    1505                 1510                 1515             


Lys Ser  Leu Lys Asn Lys Ile  Trp Val Asn Glu Phe  Arg Tyr Gly 
    1520                 1525                 1530             


Gly Phe  Ser Leu Gly Val Ser  Asn Thr Gln Ala Leu  Pro Pro Ser 
    1535                 1540                 1545             


Gln Glu  Val Asn Asp Ala Ile  Lys Gln Met Lys Lys  His Leu Lys 
    1550                 1555                 1560             


Leu Ala  Lys Asp Ser Ser Ala  Asp Arg Phe Leu Asn  Ser Leu Gly 
    1565                 1570                 1575             


Arg Phe  Met Thr Gly Leu Asp  Thr Lys Asn Asn Val  Lys Val Trp 
    1580                 1585                 1590             


Phe Asn  Asn Lys Gly Trp His  Ala Ile Ser Ser Phe  Leu Asn Val 
    1595                 1600                 1605             


Ile Asn  Asn Ala Ile Leu Arg  Ala Asn Leu Gln Lys  Gly Glu Asn 
    1610                 1615                 1620             


Pro Ser  His Tyr Gly Ile Thr  Ala Phe Asn His Pro  Leu Asn Leu 
    1625                 1630                 1635             


Thr Lys  Gln Gln Leu Ser Glu  Val Ala Leu Met Thr  Thr Ser Val 
    1640                 1645                 1650             


Asp Val  Leu Val Ser Ile Cys  Val Ile Phe Ala Met  Ser Phe Val 
    1655                 1660                 1665             


Pro Ala  Ser Phe Val Val Phe  Leu Ile Gln Glu Arg  Val Ser Lys 
    1670                 1675                 1680             


Ala Lys  His Leu Gln Phe Ile  Ser Gly Val Lys Pro  Val Ile Tyr 
    1685                 1690                 1695             


Trp Leu  Ser Asn Phe Val Trp  Asp Met Cys Asn Tyr  Val Val Pro 
    1700                 1705                 1710             


Ala Thr  Leu Val Ile Ile Ile  Phe Ile Cys Phe Gln  Gln Lys Ser 
    1715                 1720                 1725             


Tyr Val  Ser Ser Thr Asn Leu  Pro Val Leu Ala Leu  Leu Leu Leu 
    1730                 1735                 1740             


Leu Tyr  Gly Trp Ser Ile Thr  Pro Leu Met Tyr Pro  Ala Ser Phe 
    1745                 1750                 1755             


Val Phe  Lys Ile Pro Ser Thr  Ala Tyr Val Val Leu  Thr Ser Val 
    1760                 1765                 1770             


Asn Leu  Phe Ile Gly Ile Asn  Gly Ser Val Ala Thr  Phe Val Leu 
    1775                 1780                 1785             


Glu Leu  Phe Thr Asp Asn Lys  Leu Asn Asn Ile Asn  Asp Ile Leu 
    1790                 1795                 1800             


Lys Ser  Val Phe Leu Ile Phe  Pro His Phe Cys Leu  Gly Arg Gly 
    1805                 1810                 1815             


Leu Ile  Asp Met Val Lys Asn  Gln Ala Met Ala Asp  Ala Leu Glu 
    1820                 1825                 1830             


Arg Phe  Gly Glu Asn Arg Phe  Val Ser Pro Leu Ser  Trp Asp Leu 
    1835                 1840                 1845             


Val Gly  Arg Asn Leu Phe Ala  Met Ala Val Glu Gly  Val Val Phe 
    1850                 1855                 1860             


Phe Leu  Ile Thr Val Leu Ile  Gln Tyr Arg Phe Phe  Ile Arg Pro 
    1865                 1870                 1875             


Arg Pro  Val Asn Ala Lys Leu  Ser Pro Leu Asn Asp  Glu Asp Glu 
    1880                 1885                 1890             


Asp Val  Arg Arg Glu Arg Gln  Arg Ile Leu Asp Gly  Gly Gly Gln 
    1895                 1900                 1905             


Asn Asp  Ile Leu Glu Ile Lys  Glu Leu Thr Lys Ile  Tyr Arg Arg 
    1910                 1915                 1920             


Lys Arg  Lys Pro Ala Val Asp  Arg Ile Cys Val Gly  Ile Pro Pro 
    1925                 1930                 1935             


Gly Glu  Cys Phe Gly Leu Leu  Gly Val Asn Gly Ala  Gly Lys Ser 
    1940                 1945                 1950             


Ser Thr  Phe Lys Met Leu Thr  Gly Asp Thr Thr Val  Thr Arg Gly 
    1955                 1960                 1965             


Asp Ala  Phe Leu Asn Lys Asn  Ser Ile Leu Ser Asn  Ile His Glu 
    1970                 1975                 1980             


Val His  Gln Asn Met Gly Tyr  Cys Pro Gln Phe Asp  Ala Ile Thr 
    1985                 1990                 1995             


Glu Leu  Leu Thr Gly Arg Glu  His Val Glu Phe Phe  Ala Leu Leu 
    2000                 2005                 2010             


Arg Gly  Val Pro Glu Lys Glu  Val Gly Lys Val Gly  Glu Trp Ala 
    2015                 2020                 2025             


Ile Arg  Lys Leu Gly Leu Val  Lys Tyr Gly Glu Lys  Tyr Ala Gly 
    2030                 2035                 2040             


Asn Tyr  Ser Gly Gly Asn Lys  Arg Lys Leu Ser Thr  Ala Met Ala 
    2045                 2050                 2055             


Leu Ile  Gly Gly Pro Pro Val  Val Phe Leu Asp Glu  Pro Thr Thr 
    2060                 2065                 2070             


Gly Met  Asp Pro Lys Ala Arg  Arg Phe Leu Trp Asn  Cys Ala Leu 
    2075                 2080                 2085             


Ser Val  Val Lys Glu Gly Arg  Ser Val Val Leu Thr  Ser His Ser 
    2090                 2095                 2100             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Met Ala  Ile Met Val 
    2105                 2110                 2115             


Asn Gly  Arg Phe Arg Cys Leu  Gly Ser Val Gln His  Leu Lys Asn 
    2120                 2125                 2130             


Arg Phe  Gly Asp Gly Tyr Thr  Ile Val Val Arg Ile  Ala Gly Ser 
    2135                 2140                 2145             


Asn Pro  Asp Leu Lys Pro Val  Gln Asp Phe Phe Gly  Leu Ala Phe 
    2150                 2155                 2160             


Pro Gly  Ser Val Leu Lys Glu  Lys His Arg Asn Met  Leu Gln Tyr 
    2165                 2170                 2175             


Gln Leu  Pro Ser Ser Leu Ser  Ser Leu Ala Arg Ile  Phe Ser Ile 
    2180                 2185                 2190             


Leu Ser  Gln Ser Lys Lys Arg  Leu His Ile Glu Asp  Tyr Ser Val 
    2195                 2200                 2205             


Ser Gln  Thr Thr Leu Asp Gln  Val Phe Val Asn Phe  Ala Lys Asp 
    2210                 2215                 2220             


Gln Ser  Asp Asp Asp His Leu  Lys Asp Leu Ser Leu  His Lys Asn 
    2225                 2230                 2235             


Gln Thr  Val Val Asp Val Ala  Val Leu Thr Ser Phe  Leu Gln Asp 
    2240                 2245                 2250             


Glu Lys  Val Lys Glu Ser Tyr  Val 
    2255                 2260     


<210>  2426
<211>  1965
<212>  DNA
<213>  Homosapiens

<400>  2426
atgggctgct gcagctccgc ttcctccgcc gcgcagagct ccaaacgaga atggaagccg     60

ctggaggacc gtagctgcac agacatacca tggctgctgc tcttcatcct cttctgcatt    120

gggatgggat ttatttgtgg cttttcaata gcaacaggtg cagcagcaag actagtgtca    180

ggatacgaca gctatggaaa tatctgtggg cagaaaaata caaagttgga agcaatacca    240

aacagtggca tggaccacac ccagcggaag tatgtattct ttttggatcc atgcaacctg    300

gacttgataa accggaagat taagtctgta gcactgtgtg tagcagcgtg tccaaggcaa    360

gaactgaaaa ctctgagtga tgttcagaag tttgcagaga taaatggttc agccctatgt    420

agctacaacc taaagccttc tgaatacact acatctccaa aatcttctgt tctctgcccc    480

aaactaccag ttccagcgag tgcacctatt ccattcttcc atcgctgtgc tcctgtgaac    540

atttcctgct atgccaagtt tgcagaggcc ctgatcacct ttgtcagtga caatagtgtc    600

ttacacaggc tgattagtgg agtaatgacc agcaaagaaa ttatattggg actttgcttg    660

ttatcactag ttctatccat gattttgatg gtgataatca ggtatatatc aagagtactt    720

gtgtggatct taacgattct ggtcatactc ggttcacttg gaggcacagg tgtactatgg    780

tggctgtatg caaagcaaag aaggtctccc aaagaaactg ttactcctga gcagcttcag    840

atagctgaag acaatcttcg ggccctcctc atttatgcca tttcagctac agtgttcaca    900

gtgatcttat tcctgataat gttggttatg cgcaaacgtg ttgctcttac catcgccttg    960

ttccacgtag ctggcaaggt cttcattcac ttgccactgc tagtcttcca acccttctgg   1020

actttctttg ctcttgtctt gttttgggtg tactggatca tgacacttct ttttcttggc   1080

actaccggca gtcctgttca gaatgagcaa ggctttgtgg agttcaaaat ttctgggcct   1140

ctgcagtaca tgtggtggta ccatgtggtg ggcctgattt ggatcagtga atttattcta   1200

gcatgtcagc agatgacagt ggcaggagct gtggtaacat actattttac tagggataaa   1260

aggaatttgc catttacacc tattttggca tcagtaaatc gccttattcg ttaccaccta   1320

ggtacggtgg caaaaggatc tttcattatc acattagtca aaattccgcg aatgatcctt   1380

atgtatattc acagtcagct caaaggaaag gaaaatgctt gtgcacgatg tgtgctgaaa   1440

tcttgcattt gttgcctttg gtgtcttgaa aagtgcctaa attatttaaa tcagaatgca   1500

tacacagcca cagctatcaa cagcaccaac ttctgcacct cagcaaagga tgcctttgtc   1560

attctggtgg agaatgcttt gcgagtggct accatcaaca cagtaggaga ttttatgtta   1620

ttccttggca aggtgctgat agtctgcagc acaggtttag ctgggattat gctgctcaac   1680

taccagcagg actacacagt atgggtgctg cctctgatca tcgtctgcct ctttgctttc   1740

ctagtcgctc attgcttcct gtctatttat gaaatggtag tggatgtatt attcttgtgt   1800

tttgccattg atacaaaata caatgatggg agccctggca gagaattcta tatggataaa   1860

gtgctgatgg agtttgtgga aaacagtagg aaagcaatga aagaagctgg taagggaggc   1920

gtcgctgatt ccagagagct aaagccgatg ctgaagaaaa ggtga                   1965


<210>  2427
<211>  654
<212>  PRT
<213>  Homosapiens

<400>  2427

Met Gly Cys Cys Ser Ser Ala Ser Ser Ala Ala Gln Ser Ser Lys Arg 
1               5                   10                  15      


Glu Trp Lys Pro Leu Glu Asp Arg Ser Cys Thr Asp Ile Pro Trp Leu 
            20                  25                  30          


Leu Leu Phe Ile Leu Phe Cys Ile Gly Met Gly Phe Ile Cys Gly Phe 
        35                  40                  45              


Ser Ile Ala Thr Gly Ala Ala Ala Arg Leu Val Ser Gly Tyr Asp Ser 
    50                  55                  60                  


Tyr Gly Asn Ile Cys Gly Gln Lys Asn Thr Lys Leu Glu Ala Ile Pro 
65                  70                  75                  80  


Asn Ser Gly Met Asp His Thr Gln Arg Lys Tyr Val Phe Phe Leu Asp 
                85                  90                  95      


Pro Cys Asn Leu Asp Leu Ile Asn Arg Lys Ile Lys Ser Val Ala Leu 
            100                 105                 110         


Cys Val Ala Ala Cys Pro Arg Gln Glu Leu Lys Thr Leu Ser Asp Val 
        115                 120                 125             


Gln Lys Phe Ala Glu Ile Asn Gly Ser Ala Leu Cys Ser Tyr Asn Leu 
    130                 135                 140                 


Lys Pro Ser Glu Tyr Thr Thr Ser Pro Lys Ser Ser Val Leu Cys Pro 
145                 150                 155                 160 


Lys Leu Pro Val Pro Ala Ser Ala Pro Ile Pro Phe Phe His Arg Cys 
                165                 170                 175     


Ala Pro Val Asn Ile Ser Cys Tyr Ala Lys Phe Ala Glu Ala Leu Ile 
            180                 185                 190         


Thr Phe Val Ser Asp Asn Ser Val Leu His Arg Leu Ile Ser Gly Val 
        195                 200                 205             


Met Thr Ser Lys Glu Ile Ile Leu Gly Leu Cys Leu Leu Ser Leu Val 
    210                 215                 220                 


Leu Ser Met Ile Leu Met Val Ile Ile Arg Tyr Ile Ser Arg Val Leu 
225                 230                 235                 240 


Val Trp Ile Leu Thr Ile Leu Val Ile Leu Gly Ser Leu Gly Gly Thr 
                245                 250                 255     


Gly Val Leu Trp Trp Leu Tyr Ala Lys Gln Arg Arg Ser Pro Lys Glu 
            260                 265                 270         


Thr Val Thr Pro Glu Gln Leu Gln Ile Ala Glu Asp Asn Leu Arg Ala 
        275                 280                 285             


Leu Leu Ile Tyr Ala Ile Ser Ala Thr Val Phe Thr Val Ile Leu Phe 
    290                 295                 300                 


Leu Ile Met Leu Val Met Arg Lys Arg Val Ala Leu Thr Ile Ala Leu 
305                 310                 315                 320 


Phe His Val Ala Gly Lys Val Phe Ile His Leu Pro Leu Leu Val Phe 
                325                 330                 335     


Gln Pro Phe Trp Thr Phe Phe Ala Leu Val Leu Phe Trp Val Tyr Trp 
            340                 345                 350         


Ile Met Thr Leu Leu Phe Leu Gly Thr Thr Gly Ser Pro Val Gln Asn 
        355                 360                 365             


Glu Gln Gly Phe Val Glu Phe Lys Ile Ser Gly Pro Leu Gln Tyr Met 
    370                 375                 380                 


Trp Trp Tyr His Val Val Gly Leu Ile Trp Ile Ser Glu Phe Ile Leu 
385                 390                 395                 400 


Ala Cys Gln Gln Met Thr Val Ala Gly Ala Val Val Thr Tyr Tyr Phe 
                405                 410                 415     


Thr Arg Asp Lys Arg Asn Leu Pro Phe Thr Pro Ile Leu Ala Ser Val 
            420                 425                 430         


Asn Arg Leu Ile Arg Tyr His Leu Gly Thr Val Ala Lys Gly Ser Phe 
        435                 440                 445             


Ile Ile Thr Leu Val Lys Ile Pro Arg Met Ile Leu Met Tyr Ile His 
    450                 455                 460                 


Ser Gln Leu Lys Gly Lys Glu Asn Ala Cys Ala Arg Cys Val Leu Lys 
465                 470                 475                 480 


Ser Cys Ile Cys Cys Leu Trp Cys Leu Glu Lys Cys Leu Asn Tyr Leu 
                485                 490                 495     


Asn Gln Asn Ala Tyr Thr Ala Thr Ala Ile Asn Ser Thr Asn Phe Cys 
            500                 505                 510         


Thr Ser Ala Lys Asp Ala Phe Val Ile Leu Val Glu Asn Ala Leu Arg 
        515                 520                 525             


Val Ala Thr Ile Asn Thr Val Gly Asp Phe Met Leu Phe Leu Gly Lys 
    530                 535                 540                 


Val Leu Ile Val Cys Ser Thr Gly Leu Ala Gly Ile Met Leu Leu Asn 
545                 550                 555                 560 


Tyr Gln Gln Asp Tyr Thr Val Trp Val Leu Pro Leu Ile Ile Val Cys 
                565                 570                 575     


Leu Phe Ala Phe Leu Val Ala His Cys Phe Leu Ser Ile Tyr Glu Met 
            580                 585                 590         


Val Val Asp Val Leu Phe Leu Cys Phe Ala Ile Asp Thr Lys Tyr Asn 
        595                 600                 605             


Asp Gly Ser Pro Gly Arg Glu Phe Tyr Met Asp Lys Val Leu Met Glu 
    610                 615                 620                 


Phe Val Glu Asn Ser Arg Lys Ala Met Lys Glu Ala Gly Lys Gly Gly 
625                 630                 635                 640 


Val Ala Asp Ser Arg Glu Leu Lys Pro Met Leu Lys Lys Arg 
                645                 650                 


<210>  2428
<211>  4301
<212>  DNA
<213>  Homosapiens

<400>  2428
gctgcgcgca cgcgaccgca tccgggctcc ttcggccccg ccatgggctg ctgcagctcc     60

gcttcctccg ccgcgcagag ctccaaacga gaatggaagc cgctggagga ccgtagctgc    120

acagacatac catggctgct gctcttcatc ctcttctgca ttgggatggg atttatttgt    180

ggcttttcaa tagcaacagg tgcagcagca agactagtgt caggatacga cagctatgga    240

aatatctgtg ggcagaaaaa tacaaagttg gaagcaatac caaacagtgg catggaccac    300

acccagcgga agtatgtatt ctttttggat ccatgcaacc tggacttgat aaaccggaag    360

attaagtctg tagcactgtg tgtagcagcg tgtccaaggc aagaactgaa aactctgagt    420

gatgttcaga agtttgcaga gataaatggt tcagccctat gtagctacaa cctaaagcct    480

tctgaataca ctacatctcc aaaatcttct gttctctgcc ccaaactacc agttccagcg    540

agtgcaccta ttccattctt ccatcgctgt gctcctgtga acatttcctg ctatgccaag    600

tttgcagagg ccctgatcac ctttgtcagt gacaatagtg tcttacacag gctgattagt    660

ggagtaatga ccagcaaaga aattatattg ggactttgct tgttatcact agttctatcc    720

atgattttga tggtgataat caggtatata tcaagagtac ttgtgtggat cttaacgatt    780

ctggtcatac tcggttcact tggaggcaca ggtgtactat ggtggctgta tgcaaagcaa    840

agaaggtctc ccaaagaaac tgttactcct gagcagcttc agatagctga agacaatctt    900

cgggccctcc tcatttatgc catttcagct acagtgttca cagtgatctt attcctgata    960

atgttggtta tgcgcaaacg tgttgctctt accatcgcct tgttccacgt agctggcaag   1020

gtcttcattc acttgccact gctagtcttc caacccttct ggactttctt tgctcttgtc   1080

ttgttttggg tgtactggat catgacactt ctttttcttg gcactaccgg cagtcctgtt   1140

cagaatgagc aaggctttgt ggagttcaaa atttctgggc ctctgcagta catgtggtgg   1200

taccatgtgg tgggcctgat ttggatcagt gaatttattc tagcatgtca gcagatgaca   1260

gtggcaggag ctgtggtaac atactatttt actagggata aaaggaattt gccatttaca   1320

cctattttgg catcagtaaa tcgccttatt cgttaccacc taggtacggt ggcaaaagga   1380

tctttcatta tcacattagt caaaattccg cgaatgatcc ttatgtatat tcacagtcag   1440

ctcaaaggaa aggaaaatgc ttgtgcacga tgtgtgctga aatcttgcat ttgttgcctt   1500

tggtgtcttg aaaagtgcct aaattattta aatcagaatg catacacagc cacagctatc   1560

aacagcacca acttctgcac ctcagcaaag gatgcctttg tcattctggt ggagaatgct   1620

ttgcgagtgg ctaccatcaa cacagtagga gattttatgt tattccttgg caaggtgctg   1680

atagtctgca gcacaggttt agctgggatt atgctgctca actaccagca ggactacaca   1740

gtatgggtgc tgcctctgat catcgtctgc ctctttgctt tcctagtcgc tcattgcttc   1800

ctgtctattt atgaaatggt agtggatgta ttattcttgt gttttgccat tgatacaaaa   1860

tacaatgatg ggagccctgg cagagaattc tatatggata aagtgctgat ggagtttgtg   1920

gaaaacagta ggaaagcaat gaaagaagct ggtaagggag gcgtcgctga ttccagagag   1980

ctaaagccga tggcttcggg agcaagttct gcttgaacct agccgacggt tatggaaacc   2040

cattgacatt ccaaaacaat atatacacac acacataaat cagccaaaat cagagaaaag   2100

gaacagggat ttaatacctt ttttatgctt atttttgtca aacatgtact cctttcatac   2160

gggtggcttt tacaaggcaa cttccgtcat ttaatgtttt caactgtaat tgtcttaatg   2220

gaaatgttaa aattcatatc tgattaacat ttttaataac ttagaggaga ttttaacttt   2280

atttaaaaat aggtaaaatt attgtaccta attatgtcta aagtttattc aggggtaatt   2340

tccctgatgt ctgtataaaa tcaagatctt attttactga tgcataagtc ctagtgggtc   2400

aagactaggc atatgctttc agataaataa ggaattactc caatcagttt tccccaatca   2460

aagaagccat gtcattttac ttttagaaac atacaattgg gcccaatatg ggaattttca   2520

taatagttca tacatttgtc agccaacatt aaaaggtaac caactcctca ggtatttgta   2580

gtttacccta acgcttcttt aaaagaaagt aggtaaaaaa agaaaagggt agataatctt   2640

tcgtatgcaa acttttccct tatattttgt ctttctttcc tttttgactt tagtagcatc   2700

ctccacacat ttgtgtgcct gatttgaaag gaagctgggg cacccagcga gtttagcctt   2760

taagtttctg tgtattgatt tgcagattaa gtaatgctga gaggaataaa gaagggacag   2820

aaacatggaa cataaagcat tgaaaattcc ggtgcttggg cttcggcttc agagtaacgt   2880

cagtggctta gggttaaacg gccattttat tcaaatgctt gctatacaat ctgaaaacac   2940

actggcaggt gctcctctcc ttggcaattc attgagtatc cagagttcta cgatgtttaa   3000

ctgaagaatt ggctaatgtt ttgatcctcc agtgtgactg ttgtttttgt ttgggggtgg   3060

gtttggggtt ttttgctttt ttattcctga agcttaccag atatgaatgg ctaatactcc   3120

attgttctgc ttgttgtaat ggtgaatgct ttaagaaaaa aaagtgtaat ttgctaagaa   3180

taattcatga tctgtttatg cgataactcc tttttgttac aattttttta aaaaaagcta   3240

tttttgttaa tgtaaagtaa atatttcaga gcaaattttt taaacttatt gcactaaata   3300

caggctctgt acaaaaaaaa aaaaaaaaaa gcctcagcat tttatcattc catggaagga   3360

gaatcttttg aaagaaagca ttgcctccta ccagaactag acagtgaatt agatcggtat   3420

tatggaaatg catacaagta atgtcactag ggcttaataa gcagccgttt gctaatgtgc   3480

ttcctttcaa agggttggac ctttaaattg ctgcaaaagg taaattgtat ttttttttaa   3540

gtattggtgt tctttactct agctaggcta aaatttgcta aatgccttgg tttcttttaa   3600

aagttcatgt aatatttctg atttttcaga atatttgcaa taagagtctg gattttaaaa   3660

aacacatgca tacacacaat taagagctca tgtcttagca agatctggga aaccaacatt   3720

gcgagagtag ctattttgaa agaataattc tccagaagtt aacatctaat atctagtatc   3780

accaaacagt atcgctgttc tcttttattc atttgaaatg aatataatta tataactaac   3840

aattgtccaa atagatgaga gagcaaatca tgtgagaaaa ttcagaatac catctgtttc   3900

atagccgcac agattttgga ctttcacaaa cattgggaac taaatttaga attggcaaaa   3960

gtctagaaga tgggtatcaa aacagaagac attccaggag ctagcaattt taagaggtgt   4020

ccctccaaag tgacctgatg gaagtcctga acttggaaat taggttctac tcacttggac   4080

atccctgcat catggactgt tgctgctccc tgttccatat gctcgcaatc tcagctattt   4140

ggaagctacc aggaatgctt tctaattatc atttgcaact agaactgtaa tcagaaagaa   4200

attttgtatt tttgtataac ttgattgtgt gccattttat ataacaggtc ctgttttaca   4260

aataaatttt gttttactaa aaaaaaaaaa aaaaaaaaaa a                       4301


<210>  2429
<211>  657
<212>  PRT
<213>  Homosapiens

<400>  2429

Met Gly Cys Cys Ser Ser Ala Ser Ser Ala Ala Gln Ser Ser Lys Arg 
1               5                   10                  15      


Glu Trp Lys Pro Leu Glu Asp Arg Ser Cys Thr Asp Ile Pro Trp Leu 
            20                  25                  30          


Leu Leu Phe Ile Leu Phe Cys Ile Gly Met Gly Phe Ile Cys Gly Phe 
        35                  40                  45              


Ser Ile Ala Thr Gly Ala Ala Ala Arg Leu Val Ser Gly Tyr Asp Ser 
    50                  55                  60                  


Tyr Gly Asn Ile Cys Gly Gln Lys Asn Thr Lys Leu Glu Ala Ile Pro 
65                  70                  75                  80  


Asn Ser Gly Met Asp His Thr Gln Arg Lys Tyr Val Phe Phe Leu Asp 
                85                  90                  95      


Pro Cys Asn Leu Asp Leu Ile Asn Arg Lys Ile Lys Ser Val Ala Leu 
            100                 105                 110         


Cys Val Ala Ala Cys Pro Arg Gln Glu Leu Lys Thr Leu Ser Asp Val 
        115                 120                 125             


Gln Lys Phe Ala Glu Ile Asn Gly Ser Ala Leu Cys Ser Tyr Asn Leu 
    130                 135                 140                 


Lys Pro Ser Glu Tyr Thr Thr Ser Pro Lys Ser Ser Val Leu Cys Pro 
145                 150                 155                 160 


Lys Leu Pro Val Pro Ala Ser Ala Pro Ile Pro Phe Phe His Arg Cys 
                165                 170                 175     


Ala Pro Val Asn Ile Ser Cys Tyr Ala Lys Phe Ala Glu Ala Leu Ile 
            180                 185                 190         


Thr Phe Val Ser Asp Asn Ser Val Leu His Arg Leu Ile Ser Gly Val 
        195                 200                 205             


Met Thr Ser Lys Glu Ile Ile Leu Gly Leu Cys Leu Leu Ser Leu Val 
    210                 215                 220                 


Leu Ser Met Ile Leu Met Val Ile Ile Arg Tyr Ile Ser Arg Val Leu 
225                 230                 235                 240 


Val Trp Ile Leu Thr Ile Leu Val Ile Leu Gly Ser Leu Gly Gly Thr 
                245                 250                 255     


Gly Val Leu Trp Trp Leu Tyr Ala Lys Gln Arg Arg Ser Pro Lys Glu 
            260                 265                 270         


Thr Val Thr Pro Glu Gln Leu Gln Ile Ala Glu Asp Asn Leu Arg Ala 
        275                 280                 285             


Leu Leu Ile Tyr Ala Ile Ser Ala Thr Val Phe Thr Val Ile Leu Phe 
    290                 295                 300                 


Leu Ile Met Leu Val Met Arg Lys Arg Val Ala Leu Thr Ile Ala Leu 
305                 310                 315                 320 


Phe His Val Ala Gly Lys Val Phe Ile His Leu Pro Leu Leu Val Phe 
                325                 330                 335     


Gln Pro Phe Trp Thr Phe Phe Ala Leu Val Leu Phe Trp Val Tyr Trp 
            340                 345                 350         


Ile Met Thr Leu Leu Phe Leu Gly Thr Thr Gly Ser Pro Val Gln Asn 
        355                 360                 365             


Glu Gln Gly Phe Val Glu Phe Lys Ile Ser Gly Pro Leu Gln Tyr Met 
    370                 375                 380                 


Trp Trp Tyr His Val Val Gly Leu Ile Trp Ile Ser Glu Phe Ile Leu 
385                 390                 395                 400 


Ala Cys Gln Gln Met Thr Val Ala Gly Ala Val Val Thr Tyr Tyr Phe 
                405                 410                 415     


Thr Arg Asp Lys Arg Asn Leu Pro Phe Thr Pro Ile Leu Ala Ser Val 
            420                 425                 430         


Asn Arg Leu Ile Arg Tyr His Leu Gly Thr Val Ala Lys Gly Ser Phe 
        435                 440                 445             


Ile Ile Thr Leu Val Lys Ile Pro Arg Met Ile Leu Met Tyr Ile His 
    450                 455                 460                 


Ser Gln Leu Lys Gly Lys Glu Asn Ala Cys Ala Arg Cys Val Leu Lys 
465                 470                 475                 480 


Ser Cys Ile Cys Cys Leu Trp Cys Leu Glu Lys Cys Leu Asn Tyr Leu 
                485                 490                 495     


Asn Gln Asn Ala Tyr Thr Ala Thr Ala Ile Asn Ser Thr Asn Phe Cys 
            500                 505                 510         


Thr Ser Ala Lys Asp Ala Phe Val Ile Leu Val Glu Asn Ala Leu Arg 
        515                 520                 525             


Val Ala Thr Ile Asn Thr Val Gly Asp Phe Met Leu Phe Leu Gly Lys 
    530                 535                 540                 


Val Leu Ile Val Cys Ser Thr Gly Leu Ala Gly Ile Met Leu Leu Asn 
545                 550                 555                 560 


Tyr Gln Gln Asp Tyr Thr Val Trp Val Leu Pro Leu Ile Ile Val Cys 
                565                 570                 575     


Leu Phe Ala Phe Leu Val Ala His Cys Phe Leu Ser Ile Tyr Glu Met 
            580                 585                 590         


Val Val Asp Val Leu Phe Leu Cys Phe Ala Ile Asp Thr Lys Tyr Asn 
        595                 600                 605             


Asp Gly Ser Pro Gly Arg Glu Phe Tyr Met Asp Lys Val Leu Met Glu 
    610                 615                 620                 


Phe Val Glu Asn Ser Arg Lys Ala Met Lys Glu Ala Gly Lys Gly Gly 
625                 630                 635                 640 


Val Ala Asp Ser Arg Glu Leu Lys Pro Met Ala Ser Gly Ala Ser Ser 
                645                 650                 655     


Ala 
    


<210>  2430
<211>  657
<212>  DNA
<213>  Homosapiens

<400>  2430
ggcaaccgcg gcgtgactac ggcgcgcgcg gtctgggcgc ggacgggtgg ggccgggcgg     60

tgccggtgcg ggctggggca gtgcagtgag tagcggtctt ggggtgtgcg atctcgctga    120

gcctcctcac acggttcgtc gtctcgggtt cgagcccagt gggcttagcc actcgccatg    180

gactcccaga aagaagctct acagaggatc atttcaactc tggcaaataa aaatgatgaa    240

attcagaact ttattgatac actacatcat acactaaaag gagttcagga aaattcgtcc    300

aacatactct cagagttaga tgaagaattt gatagtttat actctatact ggatgaagta    360

aaagaaagta tgattaactg tatcaagcag gaacaagctc gtaaatccca agagttacag    420

agtcagatta gtcaatgtaa taatgccctg gagaactctg aagaactatt agaatttgca    480

acaaggtcat tagatataaa ggaacctgaa gaattttcaa aggtacacaa aaactgcatt    540

aatacactta acaagggaag ttgtattttt aaaaaggcgt ttttgttttt ctttagtttt    600

ggatttcttt actgatttct aatactaata aagccttggg gtttcttgat aagtaaa       657


<210>  2431
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  2431

Met Asp Ser Gln Lys Glu Ala Leu Gln Arg Ile Ile Ser Thr Leu Ala 
1               5                   10                  15      


Asn Lys Asn Asp Glu Ile Gln Asn Phe Ile Asp Thr Leu His His Thr 
            20                  25                  30          


Leu Lys Gly Val Gln Glu Asn Ser Ser Asn Ile Leu Ser Glu Leu Asp 
        35                  40                  45              


Glu Glu Phe Asp Ser Leu Tyr Ser Ile Leu Asp Glu Val Lys Glu Ser 
    50                  55                  60                  


Met Ile Asn Cys Ile Lys Gln Glu Gln Ala Arg Lys Ser Gln Glu Leu 
65                  70                  75                  80  


Gln Ser Gln Ile Ser Gln Cys Asn Asn Ala Leu Glu Asn Ser Glu Glu 
                85                  90                  95      


Leu Leu Glu Phe Ala Thr Arg Ser Leu Asp Ile Lys Glu Pro Glu Glu 
            100                 105                 110         


Phe Ser Lys Val His Lys Asn Cys Ile Asn Thr Leu Asn Lys Gly Ser 
        115                 120                 125             


Cys Ile Phe Lys Lys Ala Phe Leu Phe Phe Phe Ser Phe Gly Phe Leu 
    130                 135                 140                 


Tyr 
145 


<210>  2432
<211>  4310
<212>  DNA
<213>  Homosapiens

<400>  2432
ggcaaccgcg gcgtgactac ggcgcgcgcg gtctgggcgc ggacgggtgg ggccgggcgg     60

tgccggtgcg ggctggggca gtgcagtgag tagcggtctt ggggtgtgcg atctcgctga    120

gcctcctcac acggttcgtc gtctcgggtt cgagcccagt gggcttagcc actcgccatg    180

gactcccaga aagaagctct acagaggatc atttcaactc tggcaaataa aaatgatgaa    240

attcagaact ttattgatac actacatcat acactaaaag gagttcagga aaattcgtcc    300

aacatactct cagagttaga tgaagaattt gatagtttat actctatact ggatgaagta    360

aaagaaagta tgattaactg tatcaagcag gaacaagctc gtaaatccca agagttacag    420

agtcagatta gtcaatgtaa taatgccctg gagaactctg aagaactatt agaatttgca    480

acaaggtcat tagatataaa ggaacctgaa gaattttcaa aggctgccag acagatcaag    540

gatagagtca caatggcttc agcctttcgc ctttctttga aaccaaaggt cagtgacaac    600

atgactcatt taatggtgga tttctcacag gaaagacaga tgctgcaaac tttgaagttt    660

ttgccagtcc ccaaagctcc agagatagat ccagtagagt gtttggtggc agataactct    720

gtaacagtgg cttggagaat gccagaagaa gataataaga ttgaccattt tatactggaa    780

cataggaaga ctaattttga tggacttcca cgtgtaaagg atgagcgatg ctgggagata    840

attgataata ttaagggtac tgaatataca ctatcaggct taaaatttga ttcaaagtat    900

atgaatttca gagtgcgagc ttgtaacaag gctgtggctg gagagtattc tgatccagtg    960

actctagaga ccaaagcact taacttcaat ttggataact cctcatccca tttgaacctg   1020

aaagttgaag atacatgtgt agagtgggat cctactggag gaaaaggtca agaaagtaaa   1080

attaaaggaa aagagaacaa gggcagaagt ggtacaccat ccccaaaacg aacatctgta   1140

ggctccaggc caccagcagt aagaggcagt agagatcgtt ttactggaga atcatacaca   1200

gtgctgggag acactgctat tgaaagtgga caacattatt gggaggtcaa ggcccagaag   1260

gattgtaaat cctacagtgt gggagtagca tacaaaacgt tggggaaatt tgaccaattg   1320

ggaaagacaa acactagttg gtgtatccat gtcaacaact ggctacaaaa cacatttgca   1380

gcaaagcata ataataaagt caaagctttg gatgttactg ttcctgaaaa aataggtgta   1440

ttttgtgatt ttgatggggg tcaactttca ttctatgatg caaattctaa acagttgcta   1500

tattccttta agacaaaatt tactcagcca gtactacctg gtttcatggt atggtgtggt   1560

ggactttctt tgagtactgg gatgcaggtt ccaagtgctg tgagaacact tcagaaaagt   1620

gaaaatggaa tgactggttc agctagcagc ctgaacaatg ttgttactca atagtgtcta   1680

ctcagaatac gtttaccctc cgtcttgatt aggtggcctt ttctgtgcag ttactaatca   1740

caggaatttg gtagtagtga aaatcaggtt tgctgtgttc tgctttgagg cctggaatct   1800

tttatcatta aacacctagt acgaagcatt tgcaggaacc tactgtgcag tatcatagaa   1860

gcaagcagat accaagcaaa aaactgatga ttgaagagta aatgggggaa aaggcagtgt   1920

ttaattaaca taaaaactca tttttgtatt tcttggatta ctttgactat tctaatgttt   1980

aattacatat ggtaacccta aggcctgggg agaaaagctt ttaaatcttg ccttctttct   2040

tctgtacttt gtctttttaa aatctcatta ctatctatta tttagttcta acacagaagc   2100

tttaaaaata catagtcatc caaggttttc taaaaattga aatcatatgt tgggaatggt   2160

aaaaaggttt tcaaatggtt tatttttcct cttttataaa taagttttac aaaattttcc   2220

tcttttgttt attgactaga ttgtatataa ttttcttttt tccaaaatat tgtgataaga   2280

aatttctaga cacaacagct taaaatcacc caaatttcag ttctttacct actgcactaa   2340

caatggcaag gggggtattc tttatatgtt gccttgttta actacagttc ttttcattcc   2400

atcactttag gtgatgggta agatttttga aagccttata ttttttgatt ttgttgtcta   2460

gtttaatcct acctttaata gttgtgtttg gtaaaattcc cacttgaatg tgacactgat   2520

aataattatg ctgattttta gcatctctta taggaatcaa agtttattaa agttacatag   2580

aggattgaaa aatgtatatc actcaatttt tatctaagaa ggataggtta taaagggagg   2640

tacctaaata ctcaaataat gtatatattc tttttcataa catatggaat gctttaagca   2700

attgttttga aaaaaatctg cgtatctttg acttaattgg cacatgactt tttcaagcag   2760

ccattcattc agaggtttgt tttctctcag tccttttgct acattcactt tcttttcaaa   2820

gaaatgttaa ttattacaaa aattgacata gatatctttc ccaaacttgg ggtaaaaccc   2880

atggttatgt ggaacataac tgttcttaaa aagtcaatta taatttgtaa ctcacatcct   2940

ttgagctaaa ctaaattaaa attacagtat ttaataattc tttgggcatt tttaagaggt   3000

ctgaatttgt atttttcttc atttttgaaa ctttacattt gttgactttt tttcattctc   3060

atttaaaata tattgtgcta tgataaccaa ccttcttcca aggagtgacc attactgcct   3120

acatttgcgt tgctttctac atagagactt gtataatagt attaatagta gctcattctc   3180

tctaaaaatt tactgcccac tgataggatg ttttgtttcc ttgataaaac aaatgtaaat   3240

gaggaatttt atttgaattg gaatattgtt tttctagagg acattcatat ctgcactatt   3300

atctgatgac atgttggtaa ttttaaagac tgcaaggcag tttagagaat gaagtaaacc   3360

aatagatact cttttgattc tccaaagaaa tataattttg gtttttgttc ctcagagaga   3420

gtttgaaaga aattttcaga tgttctgttc cctatagagg gcctattcca ggatctaaat   3480

gaatgggaat ttataattcc tttcatagac tcaaacctga aagcagaaat ttttagtagt   3540

tgagttgctt taagtgaatt ttaacaaata tgacacagaa aaggtcagat gctgttgtat   3600

aaaatttttt actagtgtgt cttatataat tctttcttct cattaattca gtgccttttt   3660

cctctaagca tactcttggt ccatgcccca tgcagtgtca actgatgttt aagctacaga   3720

gcattgttgt agtggtgagg gccctctgtt gcaggggcat ggggaaatgc atatattaat   3780

caggggctgg aggagtatac atgattcttg tgttcatgtt gtcatttgaa actcttcaca   3840

taaaattttc taatattcat ttggaaaacc tctccactgg agaggtttca tctctgagag   3900

gttttgtaat aatagtgtaa gttcagtaaa tccagtccaa attctcatca catgtattat   3960

ttgatactaa attttcaatt attacttcaa aataagagtc tgaggatttc ttcttactgg   4020

cgttcttaaa ggtctctaaa attaaagaac aagatgtggt tttttgttta agacgttttt   4080

agtttatttg ttgttaagtt aaactggaga aagtttgtca tcctcatttt caaactgaaa   4140

actaatcaaa tatagtgcct atttagtctc aaaataaggt aactattaac ttgattatac   4200

tatataatat tctcaattac atttgaattt aaaaatattg agctcttgat tacaatttaa   4260

tacattgtaa aaagtattaa atcctttgaa acatcaaaaa aaaaaaaaaa              4310


<210>  2433
<211>  498
<212>  PRT
<213>  Homosapiens

<400>  2433

Met Asp Ser Gln Lys Glu Ala Leu Gln Arg Ile Ile Ser Thr Leu Ala 
1               5                   10                  15      


Asn Lys Asn Asp Glu Ile Gln Asn Phe Ile Asp Thr Leu His His Thr 
            20                  25                  30          


Leu Lys Gly Val Gln Glu Asn Ser Ser Asn Ile Leu Ser Glu Leu Asp 
        35                  40                  45              


Glu Glu Phe Asp Ser Leu Tyr Ser Ile Leu Asp Glu Val Lys Glu Ser 
    50                  55                  60                  


Met Ile Asn Cys Ile Lys Gln Glu Gln Ala Arg Lys Ser Gln Glu Leu 
65                  70                  75                  80  


Gln Ser Gln Ile Ser Gln Cys Asn Asn Ala Leu Glu Asn Ser Glu Glu 
                85                  90                  95      


Leu Leu Glu Phe Ala Thr Arg Ser Leu Asp Ile Lys Glu Pro Glu Glu 
            100                 105                 110         


Phe Ser Lys Ala Ala Arg Gln Ile Lys Asp Arg Val Thr Met Ala Ser 
        115                 120                 125             


Ala Phe Arg Leu Ser Leu Lys Pro Lys Val Ser Asp Asn Met Thr His 
    130                 135                 140                 


Leu Met Val Asp Phe Ser Gln Glu Arg Gln Met Leu Gln Thr Leu Lys 
145                 150                 155                 160 


Phe Leu Pro Val Pro Lys Ala Pro Glu Ile Asp Pro Val Glu Cys Leu 
                165                 170                 175     


Val Ala Asp Asn Ser Val Thr Val Ala Trp Arg Met Pro Glu Glu Asp 
            180                 185                 190         


Asn Lys Ile Asp His Phe Ile Leu Glu His Arg Lys Thr Asn Phe Asp 
        195                 200                 205             


Gly Leu Pro Arg Val Lys Asp Glu Arg Cys Trp Glu Ile Ile Asp Asn 
    210                 215                 220                 


Ile Lys Gly Thr Glu Tyr Thr Leu Ser Gly Leu Lys Phe Asp Ser Lys 
225                 230                 235                 240 


Tyr Met Asn Phe Arg Val Arg Ala Cys Asn Lys Ala Val Ala Gly Glu 
                245                 250                 255     


Tyr Ser Asp Pro Val Thr Leu Glu Thr Lys Ala Leu Asn Phe Asn Leu 
            260                 265                 270         


Asp Asn Ser Ser Ser His Leu Asn Leu Lys Val Glu Asp Thr Cys Val 
        275                 280                 285             


Glu Trp Asp Pro Thr Gly Gly Lys Gly Gln Glu Ser Lys Ile Lys Gly 
    290                 295                 300                 


Lys Glu Asn Lys Gly Arg Ser Gly Thr Pro Ser Pro Lys Arg Thr Ser 
305                 310                 315                 320 


Val Gly Ser Arg Pro Pro Ala Val Arg Gly Ser Arg Asp Arg Phe Thr 
                325                 330                 335     


Gly Glu Ser Tyr Thr Val Leu Gly Asp Thr Ala Ile Glu Ser Gly Gln 
            340                 345                 350         


His Tyr Trp Glu Val Lys Ala Gln Lys Asp Cys Lys Ser Tyr Ser Val 
        355                 360                 365             


Gly Val Ala Tyr Lys Thr Leu Gly Lys Phe Asp Gln Leu Gly Lys Thr 
    370                 375                 380                 


Asn Thr Ser Trp Cys Ile His Val Asn Asn Trp Leu Gln Asn Thr Phe 
385                 390                 395                 400 


Ala Ala Lys His Asn Asn Lys Val Lys Ala Leu Asp Val Thr Val Pro 
                405                 410                 415     


Glu Lys Ile Gly Val Phe Cys Asp Phe Asp Gly Gly Gln Leu Ser Phe 
            420                 425                 430         


Tyr Asp Ala Asn Ser Lys Gln Leu Leu Tyr Ser Phe Lys Thr Lys Phe 
        435                 440                 445             


Thr Gln Pro Val Leu Pro Gly Phe Met Val Trp Cys Gly Gly Leu Ser 
    450                 455                 460                 


Leu Ser Thr Gly Met Gln Val Pro Ser Ala Val Arg Thr Leu Gln Lys 
465                 470                 475                 480 


Ser Glu Asn Gly Met Thr Gly Ser Ala Ser Ser Leu Asn Asn Val Val 
                485                 490                 495     


Thr Gln 
        


<210>  2434
<211>  7349
<212>  DNA
<213>  Homosapiens

<400>  2434
gctgcagcct gctgttgagt gagaaaacaa aattatcttc ctttccaaat ccaaaaagat     60

gaaaacgact gagatacttt caaaagacaa ccaagtgagc agcacagact aatgagtaga    120

atcaataaga acgtggtttt ggccctttta acgctgacaa gttctgcatt tctgctgttt    180

cagttgtact actacaagca ctatttatca acaaagaatg gagctggttt gtcaaaatcc    240

aaaggaagcc gaattggatt tgatagcaca cagtggcgtg cagttaaaaa atttattatg    300

ttaacatcca accaaaatgt accagtgttt cttattgatc ctttgatact ggaattgatt    360

aataagaact ttgaacaagt caaaaatact tctcatggct ctacttcaca atgcaagttt    420

ttctgtgttc caagagactt tactgcattt gcactgcagt atcacctatg gaagaatgag    480

gaaggctggt ttcggatagc tgagaatatg ggatttcagt gcctaaagat tgagagtaaa    540

gatccccggc tagacgggat agactcactc tctggaactg aaatccccct gcactatatc    600

tgcaaactgg ccactcatgc gatccacttg gtagtctttc atgagaggag tggcaactac    660

ctctggcacg gccacttgag acttaaagaa cacattgaca ggaaatttgt tcccttccaa    720

aagttacagt ttggtcgtta tccaggagct tttgacaggc cagagttaca gcaagttact    780

gttgatggac tggaagttct cattccaaag gatccaatgc actttgtaga agaagtacca    840

cactctaggt ttattgagtg taggtataaa gaagctcgag cattctttca gcagtacctt    900

gatgataaca ctgtggaagc tgtggccttt cggaagagtg caaaggaatt actgcaacta    960

gcagcgaaaa cattaaacaa attgggagta ccattctggc tgagcagtgg aacttgtcta   1020

ggatggtatc gacaatgcaa cattattcct tatagcaaag atgttgacct aggaattttt   1080

atacaagatt acaaatctga tattatttta gcatttcagg atgcaggact tccgctcaaa   1140

cacaaatttg ggaaggtaga agacagcttg gaactatcct tccagggaaa agatgatgta   1200

aaacttgatg tttttttctt ctatgaagaa actgatcaca tgtggaatgg aggcactcag   1260

gccaaaacag gaaaaaaatt caaatacctg tttccgaagt ttacactgtg ctggactgag   1320

tttgtagaca tgaaggtcca tgtaccctgt gaaaccctcg aatacattga agccaactat   1380

ggtaagacct ggaagattcc tgtaaagacg tgggactgga agcgctctcc tcccaatgtg   1440

caacccaatg gaatctggcc tatttctgag tgggatgagg ttatccagtt atattgagat   1500

agtaggttga aatgggagaa tttctctttt ggaaaaaaag gtagataact gtttaaaaaa   1560

tacatgtcta tttgtcaaac ataagtggga accaaagaaa aaatgtgaca agtttgaaga   1620

cacagaaaga gtcatctgat gtaattctct cacttagtac tgaggaattt tcatgtgcca   1680

catacaatgc taggttacag tggagaagcc aagatgaatg agacaaatac ctacttcttt   1740

tattcctcct tttggtaaac aactcaattt tcctttgagg gaaccctccc ccaccctttg   1800

aagagttcaa gttctgtaca ggtttttaaa acgtgaagta atgtttgaac tggaagatga   1860

gctcaccagg caaagctaag gaaggatata ctagttgaaa agaataaccc actcctcttc   1920

tgggcattta agctggtatg ttagtgctac ttttaagatt gtggagtctg agttaatatt   1980

caagtgatca gactttgagt gacatcaaga aaagatgata tcaggttcat ttttcaacta   2040

atcttatgtg gaattgaatt agagaacaag gcattattct tttagggaag gtgagagctt   2100

atttgtatca gagcttatta cttgtcagga taagtaaatt tctgtacatg tactgttttc   2160

atatgtgaag tgagaagaaa ctttatgctt gtttaatgct taaatttcca tccattgtga   2220

gaatattttc actgacctct gatggcactt gttgacaaat cattcaagtg agaccatgtt   2280

actagacatg atcttgaaag aggccatgat ttcacaaaac tcatttttat tttattctca   2340

gacagtctgt taggtaaaaa tatgagaaat tcatgtacat tttatatttt ctgaatttat   2400

aatctgtgca ctcccaattt taatgacact aaaatattaa tagaattttt taaatatact   2460

ctaattttta aaacatactc tttattatct tcatttatca attacagctt cgtatctcta   2520

atttatggtc tatataccaa tttaaatggc atgtaaacct gcctgtttct tctcctcttc   2580

taatatatca gatctccaaa atggaagcta aatggtggac ttgacaacta ttcaccctac   2640

ctcagatcat agagtttgta aagtttgtgt ccctccccag tttttcagtc tgttgaatgt   2700

cgatggggca agaactcaga cttctacttt accaagtacc acacactctg gaatgcttta   2760

gtttcctttt cccctcaaga tgtctgagtc agctaggatg ctgtttaccc catctctctc   2820

ttatatcact tgaatgatat attgtaagtg agaggtaaag gaaaatgtag gcacaataag   2880

cactgctatt tttctctttg tctaggaaag gaagctgaat cttatatctt atctatgcta   2940

tttaggacta ctttctggag cttggcagat tttcctctga caccagagaa caatagtagt   3000

ctcaagaatg gaaacctgaa tgtctgaggg aatgggctgg tagacttttt cgaaaacaaa   3060

ttagagaaag taacttacaa ccacccattc cggatttgta aagcaacatg aaaacctttg   3120

ataaatgata accaacagtc ttctgtccta atttgcattc tcaatgcaga attattgggt   3180

ctttcataaa caacatgagt ggtttctgga gacatttaag attgtcagca aacttgtccc   3240

aaaatggcac atcatcataa tccattttct ctttgctaga aaatcagccc atagagtgca   3300

ttcccaaatt ctaaatagct gaccctaaat tcatttttca tgcttaaaaa taatagaaca   3360

aataataata ctatttttgg gcaaaatcca ccctacttga tgaggaccat ttgcttgtgc   3420

tcagtattta gaaatgcata cactccacat ttctccccat ttccaattgg gactcccatt   3480

ctttgccagg agatcttacc catccctttt cagattaatc ttttatcctt tcctgaagta   3540

caaagtctta agagtgtctg aaatccaaga catcttggcc caattgacac aggttctata   3600

ttcttcccta catagaccac tggctgctga aatacttttc ttgtcttctg gtttcacagg   3660

cttcagctca tgggttccac cctaacttgg ggaaacaaaa gccttctcta gaatctgaag   3720

gccaggctta cctctgattc tgattcatcc atacttcatc ttatgtattt taacagttgg   3780

gttctgtgga gtgtccagag accttgggtt aggtatatcc atcttcagta cctcattgga   3840

tcacttttct ttcatcactt gagtattcta gcagtcattc tcctaatctg accactttca   3900

ggtttagttt acctggctta ccaggggaag ttgacaactt gttggtagtt aggcacccat   3960

gaatgtctcc agagacatcc tgagaggcaa gattcctctt aattgataac caggacaacc   4020

aggtagtcac ccagtcctct ctaagcaggg agcacttgtc cttctctcct ctgctgcagc   4080

tactgatatc tggcccctgg aataaaacca tagttcctaa aattgagcat ccctaagagt   4140

agctgcttgg tgggacagct gatttctttg attccctagc tgcaaaacct gaaattgacc   4200

actaggtgac agaatgtttg ccagtatccc cacaaaacaa gttaaaactt aagtgaaaat   4260

cattctgctt ttgaatctta aaagctagaa aaaccataat gtaatattct ttttaaaccc   4320

tcttatttta taactaaata aataatcaca gaaaagaatg atctgaacaa gaacagctga   4380

ggctaaaacc caagactgcc gtgactccta gtccaatgtc tgtttcgcat cacaacacag   4440

tatctttaac agtgcttgag atgcttaaca gagaaggcat ccagtgcttc attgaggcta   4500

agtctcaggg tgtttctgcc gcttagtatc tttttgttca gattgagaac ctaaggcgac   4560

agagaggtca aggggaagta ttttctagtt cagaattcag aattcttagg caaccttcat   4620

acctttatct ggaaaatgcc ttctctccag acaataagac agttcacatc tggagacatc   4680

agcctttggt acctaattct ctaagctcaa gatgcatccc attgccactt taccattcta   4740

tttcccaagg gaaccatcag caccaacctg ctaaatgcct gtatttgaag tctctcccct   4800

tcctgaagtg accttttatg aggctctttc cttcctaagg gacctttccc tggtagtagt   4860

ggtctcattc acaaaaaaga ataatagatg taactggagt cactttgcag ttttcaagat   4920

ttttttttta tctgcttggc tggaaaggag actagagtat ctagttttta gtatttaaac   4980

tacttttaat tatttatatt gatactctct gataaatgca ggtagttaag aatagattgt   5040

actcattcct ttttgagttt gtgacctcaa accattgttt ttattcttac acgactacag   5100

tacttcaaat ggcacataga taggcaggat attacatagg taagcaggaa tttatacatt   5160

gggtaccaga gctaaatctg gaaaacacat ttggaatgag cttccacact tcagtctaaa   5220

atctcaccca aacttatggc tacatatttt tctaagtttc ccccctagtt tcactttctg   5280

gaaagtgaac agttttttaa atcctaaatg ttataaatcc ttaggagaaa tattccctca   5340

aaacctagtc aagaaagtgc cacattccca ccttctaaca ggtaattatt agttgtaata   5400

gctttaatgc atggaaaaac ttcagttact gaccagtcaa gagaatttct caagaaaaat   5460

cccagcaacg ttccctcttt cctccttgtc ttccactatc attaagacct gggctagatc   5520

acctctaaca tctcactcag ggaaggcaat gtgttgccat aaaaagacca caagcttttg   5580

agttaggcct gaatttgaat ttcagcttaa tcatgtggga tttatggtgg gggccctttc   5640

agtctcaatt tccacattag tgaactgggg aaatgataca tacttctaag ggtttttagg   5700

gggattaaat gaagtataca gttcttagcc tcaggcctag gattaagtaa gtactcaaga   5760

aatgtgcaat tttctagttc catgtttctt ttctaatctt caaatggaat tatagaaacc   5820

atgggtcaga acatattcct ttactcaaaa gattgcatga ctgaatttgc ttaagaaaaa   5880

aaaaattgta tcaagtcatt aatacaatta tacattaatt atattacatt aatacaatat   5940

atggtttgtg aattcagaga cattaccagt ttgcctcctt ctctcaatag aacttgtatt   6000

ttcattttct tggttaagca gttgtctcct aatattatcc catatgctac ctagtttgct   6060

ggtcccaagc agtttactgt acttcactag atttggtacc tgctctcccc tggacttctt   6120

tttcaatatt ctagcctttc ctagatgtaa atctttacct ccttgttagt gaaattagat   6180

ataagccatg atttggagag ggaagaaatc tggaatactt aatttcattt aattatctat   6240

gctgatgaat gcctgtatca ttgttaataa aggagaattg aaaatactca tttctacttt   6300

ctgccctcaa atttctgttt ctatctcaac taggcaagaa tcagcagggt gcatgatgcc   6360

attttaagct gcttcacatc agactgaaat cctaattaca gttcataagt gaaacagact   6420

aattcaatgg caataccttt tgtataggtc ctgtgcttaa aggaggcaag tataaatttt   6480

ctaataagaa atccctgctt cttttgggtg cagtggctca cacctgtaat accagcagtt   6540

tgagaagcta aggcaggtgg atcacttgag gccaggagtt cgagaccagc ctggccaaca   6600

tagtgaaacc ccgtctcttc taaaaataca aaaaaattag ctgggcatgg tggtgcacgc   6660

ctatagtccc agctacacag gaggctgagg caggagaatc acttgaaccc gggaagcaga   6720

gtctgcagtg agccaagatc gcggcattgc acttcagcct gggcgataga gcaagactct   6780

gtctcagaaa aaaaaaaaag gaaagaaaga aatctctgct tccgtactat caaaacttct   6840

accctagaat accccctggc accttctaac ccaacctaat acagagattt tgtagggacc   6900

cattaacaag ctcctatata attataagca gctctcacag tagggttgaa agagaatata   6960

aggaaaatta gaagtactgt atttttgcta ttggaaatga aatattgttt catgcacctt   7020

tgaaaaaaat aacaggattt tacagccttc tgatgattca ttcaaagcat ggggaatagt   7080

tcatatgttt gttaaatgaa aatcttatgt agcaatttgt gtgtccctcc cacttcataa   7140

ctacaaaaac atatatatga atttctaaac aaagtgatat tttaaagatg aattgattca   7200

atgtgtactt accagtttac tgtgtggttt tatcttcagg tacagatagt ttgtggtact   7260

acttgaaaat acctttaata ttattttcat cagaatttgt aatatataat ccagtttggg   7320

atgatgaata aaatttttct aatctcttg                                     7349


<210>  2435
<211>  461
<212>  PRT
<213>  Homosapiens

<400>  2435

Met Ser Arg Ile Asn Lys Asn Val Val Leu Ala Leu Leu Thr Leu Thr 
1               5                   10                  15      


Ser Ser Ala Phe Leu Leu Phe Gln Leu Tyr Tyr Tyr Lys His Tyr Leu 
            20                  25                  30          


Ser Thr Lys Asn Gly Ala Gly Leu Ser Lys Ser Lys Gly Ser Arg Ile 
        35                  40                  45              


Gly Phe Asp Ser Thr Gln Trp Arg Ala Val Lys Lys Phe Ile Met Leu 
    50                  55                  60                  


Thr Ser Asn Gln Asn Val Pro Val Phe Leu Ile Asp Pro Leu Ile Leu 
65                  70                  75                  80  


Glu Leu Ile Asn Lys Asn Phe Glu Gln Val Lys Asn Thr Ser His Gly 
                85                  90                  95      


Ser Thr Ser Gln Cys Lys Phe Phe Cys Val Pro Arg Asp Phe Thr Ala 
            100                 105                 110         


Phe Ala Leu Gln Tyr His Leu Trp Lys Asn Glu Glu Gly Trp Phe Arg 
        115                 120                 125             


Ile Ala Glu Asn Met Gly Phe Gln Cys Leu Lys Ile Glu Ser Lys Asp 
    130                 135                 140                 


Pro Arg Leu Asp Gly Ile Asp Ser Leu Ser Gly Thr Glu Ile Pro Leu 
145                 150                 155                 160 


His Tyr Ile Cys Lys Leu Ala Thr His Ala Ile His Leu Val Val Phe 
                165                 170                 175     


His Glu Arg Ser Gly Asn Tyr Leu Trp His Gly His Leu Arg Leu Lys 
            180                 185                 190         


Glu His Ile Asp Arg Lys Phe Val Pro Phe Gln Lys Leu Gln Phe Gly 
        195                 200                 205             


Arg Tyr Pro Gly Ala Phe Asp Arg Pro Glu Leu Gln Gln Val Thr Val 
    210                 215                 220                 


Asp Gly Leu Glu Val Leu Ile Pro Lys Asp Pro Met His Phe Val Glu 
225                 230                 235                 240 


Glu Val Pro His Ser Arg Phe Ile Glu Cys Arg Tyr Lys Glu Ala Arg 
                245                 250                 255     


Ala Phe Phe Gln Gln Tyr Leu Asp Asp Asn Thr Val Glu Ala Val Ala 
            260                 265                 270         


Phe Arg Lys Ser Ala Lys Glu Leu Leu Gln Leu Ala Ala Lys Thr Leu 
        275                 280                 285             


Asn Lys Leu Gly Val Pro Phe Trp Leu Ser Ser Gly Thr Cys Leu Gly 
    290                 295                 300                 


Trp Tyr Arg Gln Cys Asn Ile Ile Pro Tyr Ser Lys Asp Val Asp Leu 
305                 310                 315                 320 


Gly Ile Phe Ile Gln Asp Tyr Lys Ser Asp Ile Ile Leu Ala Phe Gln 
                325                 330                 335     


Asp Ala Gly Leu Pro Leu Lys His Lys Phe Gly Lys Val Glu Asp Ser 
            340                 345                 350         


Leu Glu Leu Ser Phe Gln Gly Lys Asp Asp Val Lys Leu Asp Val Phe 
        355                 360                 365             


Phe Phe Tyr Glu Glu Thr Asp His Met Trp Asn Gly Gly Thr Gln Ala 
    370                 375                 380                 


Lys Thr Gly Lys Lys Phe Lys Tyr Leu Phe Pro Lys Phe Thr Leu Cys 
385                 390                 395                 400 


Trp Thr Glu Phe Val Asp Met Lys Val His Val Pro Cys Glu Thr Leu 
                405                 410                 415     


Glu Tyr Ile Glu Ala Asn Tyr Gly Lys Thr Trp Lys Ile Pro Val Lys 
            420                 425                 430         


Thr Trp Asp Trp Lys Arg Ser Pro Pro Asn Val Gln Pro Asn Gly Ile 
        435                 440                 445             


Trp Pro Ile Ser Glu Trp Asp Glu Val Ile Gln Leu Tyr 
    450                 455                 460     


<210>  2436
<211>  327
<212>  DNA
<213>  Homosapiens

<400>  2436
atgaccagga agatcttcac aaataccagg gagcggtgga ggcagcagaa tgtcaacagc     60

gcctttgcca agctgaggaa gctcatcccc actcaccctc cagacaaaaa gctgagcaaa    120

aatgaaacgc ttcgcctggc aatgaggtat atcaacttct tggtcaaggt cttgggggag    180

caaagcctgc aacaaacggg agtggctgct caggggaaca ttctggggct cttccctcaa    240

ggaccccacc tgccaggcct ggaggacaga actctgcttg agaactacca ggttccttca    300

cctggtccaa gccaccacat tccttag                                        327


<210>  2437
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  2437

Met Thr Arg Lys Ile Phe Thr Asn Thr Arg Glu Arg Trp Arg Gln Gln 
1               5                   10                  15      


Asn Val Asn Ser Ala Phe Ala Lys Leu Arg Lys Leu Ile Pro Thr His 
            20                  25                  30          


Pro Pro Asp Lys Lys Leu Ser Lys Asn Glu Thr Leu Arg Leu Ala Met 
        35                  40                  45              


Arg Tyr Ile Asn Phe Leu Val Lys Val Leu Gly Glu Gln Ser Leu Gln 
    50                  55                  60                  


Gln Thr Gly Val Ala Ala Gln Gly Asn Ile Leu Gly Leu Phe Pro Gln 
65                  70                  75                  80  


Gly Pro His Leu Pro Gly Leu Glu Asp Arg Thr Leu Leu Glu Asn Tyr 
                85                  90                  95      


Gln Val Pro Ser Pro Gly Pro Ser His His Ile Pro 
            100                 105             


<210>  2438
<211>  2076
<212>  DNA
<213>  Homosapiens

<400>  2438
gctggagccg gcgcggagga gcgggcggcc gcggctgtgc cctctcctac tcctcaccgc     60

gcgcgcgcgg ggaaccagta gccgcggctg cttcggttgc cgcggtcggt ggtcgttatg    120

gattctccat gggacgagtt ggctctggcc ttctcccgca cgtccatgtt tccctttttt    180

gacatcgcgc actatctagt gtcagtgatg gcggtgaaac gtcagccggg agcagctgca    240

ttggcatgga agaatcctat ttcaagctgg tttactgcta tgctccactg ttttggtgga    300

ggaattttat cctgtctact gcttgcagag cctccattga agtttcttgc aaaccacact    360

aacatattac tggcatcttc aatctggtat attacatttt tttgcccgca tgacctagtt    420

tcccagggct attcatatct acctgttcaa ctactggctt cgggaatgaa ggaagtgacc    480

agaacttgga aaatagtagg tggagtcaca catgctaata gctattacaa aaatggctgg    540

atagtcatga tagctattgg atgggcccga ggtgcaggtg gtaccattat aacgaatttt    600

gagaggttgg taaaaggaga ttggaaacca gaaggtgatg aatggctgaa gatgtcatac    660

cctgccaagg taaccctgct ggggtcagtt atcttcacat tccagcacac ccagcatctg    720

gcaatatcaa agcataatct tatgttcctt tataccatct ttattgtggc cacaaagata    780

accatgatga ctacacagac ttctactatg acatttgctc cttttgagga tacattgagt    840

tggatgctat ttggctggca gcagccgttt tcatcatgtg agaagaaaag tgaagcaaag    900

tcaccttcca atggcgttgg gtcattggcc tcaaagccgg tagatgttgc ctcagataat    960

gttaaaaaga aacatactaa gaagaatgaa taaatttacg tgatgagctc tacaaggcca   1020

aaaatttttt ttcttatcta cctgttatat tgtgctaatt tttctatgta tgtgatgtga   1080

aatgaagact atatatatgg aatggaggtg acagaaagaa agaaattctt tgtttgaggg   1140

agacttcccc tttctggatt gtatttgtag agtgttacga gtgtatcatg tgattatgct   1200

ttaccggtat aagagattct gttgtgatta tttgaatagt tttatattaa taaaagaaga   1260

caaaattttt taaatgttag aaaaagcaga tctgtcattg caaagtaaca aaaattttaa   1320

gcttttaaaa atgtagattt ttcatatttt taaaatttga atctatttga gctttagttc   1380

agcagaatta aatttttact tgacattatc attaaaattg ctaggtatgg agaacaattc   1440

ctattttatt ttgaacactg agaagagtaa acttttccta aaacacttta tattataaat   1500

gaaaataaat tgctagttta tattttagat ataaacatca tattttttat taatacctac   1560

atcaaatgga aaatatctga aatttttttt ccatagcagg tattttctac tagaagtagt   1620

tttactactt ttcatttaga acagagtatg agtcttaatc tgaagtcttt ttcatgccct   1680

tgttttaaaa aaactacttt ttttggcctc aaaaaaatca agggtgtaat ttttaataaa   1740

ttgttaatcc tatgttttgt aattttcatt ttaggagctt gacttatttt tttctctctc   1800

ataaaaacac atttgtttta attgtaggag aaattttctc agcattttgc atgttctttc   1860

taatctttgt tggtctgaat atattggtag taattactgt aattattcaa caaaaagcat   1920

atccgttcaa aaatttttcc actatgtctt ttttctagtg gctactgttt tagttttcta   1980

gttgaatatc tctgacaagc tttcgtatgg ttttgttata tcttcatcta catgtaatgt   2040

gttattaatt ttattaaatg aaaactaatc accttc                             2076


<210>  2439
<211>  291
<212>  PRT
<213>  Homosapiens

<400>  2439

Met Asp Ser Pro Trp Asp Glu Leu Ala Leu Ala Phe Ser Arg Thr Ser 
1               5                   10                  15      


Met Phe Pro Phe Phe Asp Ile Ala His Tyr Leu Val Ser Val Met Ala 
            20                  25                  30          


Val Lys Arg Gln Pro Gly Ala Ala Ala Leu Ala Trp Lys Asn Pro Ile 
        35                  40                  45              


Ser Ser Trp Phe Thr Ala Met Leu His Cys Phe Gly Gly Gly Ile Leu 
    50                  55                  60                  


Ser Cys Leu Leu Leu Ala Glu Pro Pro Leu Lys Phe Leu Ala Asn His 
65                  70                  75                  80  


Thr Asn Ile Leu Leu Ala Ser Ser Ile Trp Tyr Ile Thr Phe Phe Cys 
                85                  90                  95      


Pro His Asp Leu Val Ser Gln Gly Tyr Ser Tyr Leu Pro Val Gln Leu 
            100                 105                 110         


Leu Ala Ser Gly Met Lys Glu Val Thr Arg Thr Trp Lys Ile Val Gly 
        115                 120                 125             


Gly Val Thr His Ala Asn Ser Tyr Tyr Lys Asn Gly Trp Ile Val Met 
    130                 135                 140                 


Ile Ala Ile Gly Trp Ala Arg Gly Ala Gly Gly Thr Ile Ile Thr Asn 
145                 150                 155                 160 


Phe Glu Arg Leu Val Lys Gly Asp Trp Lys Pro Glu Gly Asp Glu Trp 
                165                 170                 175     


Leu Lys Met Ser Tyr Pro Ala Lys Val Thr Leu Leu Gly Ser Val Ile 
            180                 185                 190         


Phe Thr Phe Gln His Thr Gln His Leu Ala Ile Ser Lys His Asn Leu 
        195                 200                 205             


Met Phe Leu Tyr Thr Ile Phe Ile Val Ala Thr Lys Ile Thr Met Met 
    210                 215                 220                 


Thr Thr Gln Thr Ser Thr Met Thr Phe Ala Pro Phe Glu Asp Thr Leu 
225                 230                 235                 240 


Ser Trp Met Leu Phe Gly Trp Gln Gln Pro Phe Ser Ser Cys Glu Lys 
                245                 250                 255     


Lys Ser Glu Ala Lys Ser Pro Ser Asn Gly Val Gly Ser Leu Ala Ser 
            260                 265                 270         


Lys Pro Val Asp Val Ala Ser Asp Asn Val Lys Lys Lys His Thr Lys 
        275                 280                 285             


Lys Asn Glu 
    290     


<210>  2440
<211>  4104
<212>  DNA
<213>  Homosapiens

<400>  2440
ctgcaggtta ttcagcgata gttatgacct cccggttacg tgcgttgggt ggaagaatta     60

ataatatacg cacctcggag ttacccaaag agaaaactcg atcagaagtc atttgcagca    120

tccacttttt agatggcgtg gtacagacct ttaaagttac taaacaagac actggccagg    180

ttcttctgga tatggtgcac aaccacctgg gtgtgactga aaaggaatat tttggtttac    240

agcatgatga cgactccgtg gactctccta gatggctgga agcaagcaaa gccatcagga    300

agcagttaaa aggaggtttc ccctgtaccc tgcattttcg agtaagattt tttatacctg    360

atcccaacac actgcagcaa gaacaaacca ggcacttgta tttcttacaa ctgaagatgg    420

atatttgcga aggaaggtta acctgccctc ttaactcagc agtggttcta gcgtcctatg    480

ccgtacaatc tcattttgga gactataatt cttccataca tcatccaggc tatctttccg    540

atagtcactt tatacccgat caaaatgagg actttttaac aaaagtcgaa tctctgcatg    600

agcagcacag tgggctaaaa caatcagaag cagaatcctg ctatatcaac atagcgcgga    660

ccctcgactt ctatggagta gaactgcaca gtggtaggga tctgcacaat ttagacctaa    720

tgattggaat tgcttccgcg ggtgttgctg tgtaccgaaa atacatttgc acaagtttct    780

atccttgggt gaacattctc aaaatttctt tcaaaaggaa aaagttcttc atacatcagc    840

gacagaaaca ggctgaatcc agggaacata ttgtggcctt caacatgctg aattaccgat    900

cttgcaaaaa cttgtggaaa tcctgtgttg agcaccatac gttctttcag gcaaagaagc    960

tactacctca ggaaaagaat gttctgtctc agtactggac tatgggctct cggaacacca   1020

aaaagtcggt aaataaccaa tattgcaaaa aggtgattgg cgggatggtg tggaacccag   1080

ccatgcggag atccttatca gtggagcact tagaaaccaa gagtctgcct tctcgttccc   1140

ctcccattac tcccaactgg cgaagtcctc ggctccggca cgaaatccga aagccacgcc   1200

actcttctgc agataacctt gcaaatgaaa tgacctacat cacggaaacg gaagatgtat   1260

tttacacgta caagggctct ctggcccctc aagacagcga ttctgaagtt tctcagaacc   1320

gaagcccgca ccaagagagt ttatccgaga acaatccggc acaaagctac ctgacccaga   1380

agtcatccag ttctgtgtct ccatcttcaa atgctccagg ctcctgctca cctgacggcg   1440

ttgatcagca gctcttagat gacttccaca gggtgaccaa agggggctcc accgaggacg   1500

ccagccagta ctactgtgac aagaatgata atggtgacag ctacttagtc ttgatccgta   1560

tcacaccaga tgaagatgga aaatttggat ttaatcttaa gggaggagtg gatcaaaaga   1620

tgcctcttgt ggtatcaagg ataaacccag agtcacctgc ggacacctgc attcctaagc   1680

tgaacgaagg ggatcaaatc gtgttaatca atggccggga catctcagaa cacacgcatg   1740

accaagtggt gatgttcatc aaagccagcc gggagtccca ctcacgggag ctggccctgg   1800

tgatcaggag gagagctgtc cgctcatttg ctgacttcaa gtctgaagat gaactgaacc   1860

agcttttccc cgaagccatt ttccccatgt gtccggaggg tggggacact ttggagggat   1920

ccatggcaca gctaaagaag ggcctcgaaa gcgggacggt gctgatccag tttgagcaac   1980

tctacagaaa aaagccaggt ttggccatca cgtttgcaaa gctgcctcaa aatttggaca   2040

aaaaccgata taaagatgtg ctgccttatg acaccacccg ggtattattg cagggaaatg   2100

aagattatat taatgcaagt tacgtgaaca tggaaattcc tgctgctaac cttgtgaaca   2160

agtacatcgc cactcagggg cccctgccgc atacctgtgc acagttttgg caggttgtct   2220

gggatcagaa gttgtcactc attgtcatgt tgacgactct cacagaacga gggcggacca   2280

aatgtcacca gtactggcca gatccccccg acgtcatgaa ccacggcggc tttcacatcc   2340

agtgtcagtc agaggactgc accatcgcct atgtgtcccg agaaatgctg gtcacaaaca   2400

cccagaccgg ggaagaacac acagtgacac atctccagta cgtcgcatgg cctgaccacg   2460

gtgtgcccga tgactcctcc gactttctgg aatttgtaaa ctatgtgagg tctctgagag   2520

tggacagcga gcctctccta gttcactgca gtgctggaat aggtcgaacc ggtgtgttgg   2580

tcactatgga aacagccatg tgcctaactg agaggaacct gcccatttac ccactggata   2640

ttgtccgaaa aatgcgagac cagcgcgcca tgatggtgca gacatcaagc cagtacaagt   2700

ttgtgtgtga agcgattctt cgtgtgtatg aagaaggttt agtccaaatg ctggatccta   2760

gttaagacaa ctgtgaaaaa gttcattcct ctttcccaag ggcatcctcc ttgaaagagg   2820

aggacagacc tctctggaag cagcaagagg aaccagtagc tgtgggaaag gaatgggcac   2880

ctctgaaccc aggcacttta aacttctata gaaaagatat cgtgtacata ggaactggtg   2940

tagataagca tgcaattatg gcatcattta ggcctgtatt tctatggaaa gatacaaaaa   3000

ggatctcagt ttggggcctg tcctaatgcc ttcttcccta acatcaccac acacacccct   3060

gtcggcatcc tggagcaatt gagaccggac acccacagag ctgttgtcct cccagcaaca   3120

agatggtgtg gttatcttgg gtcatttgga tgttttgttt gtttctgtgt gtcagactgt   3180

aagggctgag ctttctgtgc ttctaggtgg agctggaaca attcagattc acccgccctg   3240

atgctaagga aaccctgacg tatgtactag atggcagggc actgggggtc aggctgaagg   3300

ctgagcaaca cctctctgcc ctccctccct ttgtcccatc tcccagcgac ttccaatatt   3360

catgtttctg agaattgtgt ccctcttcag gttccctctt ggtgcctaac ctggattagt   3420

aatgtgcatt caggtgaatt ttcagctgag gctctgagaa ctggtactct cagtgtgttc   3480

tggtcatctt gtggcttagt tgtagaagca ggtgtgtctc ttgcctctgc ttgcctccta   3540

ctgcacactc agcacccagg actggaatca ccgactactg aatctcctac atgtattgct   3600

gctacttcaa gctcctccac ttgaaacctt atgattttcc caaggggaga tgggacagtg   3660

tcatctaaat attccgaatg tttggccttc tgagaaaaga gcttctagta attgaaccat   3720

gggaaaccca gcttctggag ggttggccgt ggggctgtgt acatgtgtgt gcccaggggt   3780

gagtgtttct caggattcct aacgattcaa attaccgttg agtatatata aagaatgagt   3840

ctctgtatgg aagaacaaat gtgtgcattc acccccagtc acaatggtct ccattgcatt   3900

tcaaaggaga ggatcagact atctgaatat aaacacaatc tgatgttaat ttattctaag   3960

aacaccatca ttttgattgt cctaaagaat tctgcctttg tgaataccgt gttaaatttt   4020

tttaaatttg tgacaggatt gtagcaaatt attatttaag gaaaataaat tgtgtaaaca   4080

tttaaaaaaa aaaaaaaaaa aaaa                                          4104


<210>  2441
<211>  913
<212>  PRT
<213>  Homosapiens

<400>  2441

Met Thr Ser Arg Leu Arg Ala Leu Gly Gly Arg Ile Asn Asn Ile Arg 
1               5                   10                  15      


Thr Ser Glu Leu Pro Lys Glu Lys Thr Arg Ser Glu Val Ile Cys Ser 
            20                  25                  30          


Ile His Phe Leu Asp Gly Val Val Gln Thr Phe Lys Val Thr Lys Gln 
        35                  40                  45              


Asp Thr Gly Gln Val Leu Leu Asp Met Val His Asn His Leu Gly Val 
    50                  55                  60                  


Thr Glu Lys Glu Tyr Phe Gly Leu Gln His Asp Asp Asp Ser Val Asp 
65                  70                  75                  80  


Ser Pro Arg Trp Leu Glu Ala Ser Lys Ala Ile Arg Lys Gln Leu Lys 
                85                  90                  95      


Gly Gly Phe Pro Cys Thr Leu His Phe Arg Val Arg Phe Phe Ile Pro 
            100                 105                 110         


Asp Pro Asn Thr Leu Gln Gln Glu Gln Thr Arg His Leu Tyr Phe Leu 
        115                 120                 125             


Gln Leu Lys Met Asp Ile Cys Glu Gly Arg Leu Thr Cys Pro Leu Asn 
    130                 135                 140                 


Ser Ala Val Val Leu Ala Ser Tyr Ala Val Gln Ser His Phe Gly Asp 
145                 150                 155                 160 


Tyr Asn Ser Ser Ile His His Pro Gly Tyr Leu Ser Asp Ser His Phe 
                165                 170                 175     


Ile Pro Asp Gln Asn Glu Asp Phe Leu Thr Lys Val Glu Ser Leu His 
            180                 185                 190         


Glu Gln His Ser Gly Leu Lys Gln Ser Glu Ala Glu Ser Cys Tyr Ile 
        195                 200                 205             


Asn Ile Ala Arg Thr Leu Asp Phe Tyr Gly Val Glu Leu His Ser Gly 
    210                 215                 220                 


Arg Asp Leu His Asn Leu Asp Leu Met Ile Gly Ile Ala Ser Ala Gly 
225                 230                 235                 240 


Val Ala Val Tyr Arg Lys Tyr Ile Cys Thr Ser Phe Tyr Pro Trp Val 
                245                 250                 255     


Asn Ile Leu Lys Ile Ser Phe Lys Arg Lys Lys Phe Phe Ile His Gln 
            260                 265                 270         


Arg Gln Lys Gln Ala Glu Ser Arg Glu His Ile Val Ala Phe Asn Met 
        275                 280                 285             


Leu Asn Tyr Arg Ser Cys Lys Asn Leu Trp Lys Ser Cys Val Glu His 
    290                 295                 300                 


His Thr Phe Phe Gln Ala Lys Lys Leu Leu Pro Gln Glu Lys Asn Val 
305                 310                 315                 320 


Leu Ser Gln Tyr Trp Thr Met Gly Ser Arg Asn Thr Lys Lys Ser Val 
                325                 330                 335     


Asn Asn Gln Tyr Cys Lys Lys Val Ile Gly Gly Met Val Trp Asn Pro 
            340                 345                 350         


Ala Met Arg Arg Ser Leu Ser Val Glu His Leu Glu Thr Lys Ser Leu 
        355                 360                 365             


Pro Ser Arg Ser Pro Pro Ile Thr Pro Asn Trp Arg Ser Pro Arg Leu 
    370                 375                 380                 


Arg His Glu Ile Arg Lys Pro Arg His Ser Ser Ala Asp Asn Leu Ala 
385                 390                 395                 400 


Asn Glu Met Thr Tyr Ile Thr Glu Thr Glu Asp Val Phe Tyr Thr Tyr 
                405                 410                 415     


Lys Gly Ser Leu Ala Pro Gln Asp Ser Asp Ser Glu Val Ser Gln Asn 
            420                 425                 430         


Arg Ser Pro His Gln Glu Ser Leu Ser Glu Asn Asn Pro Ala Gln Ser 
        435                 440                 445             


Tyr Leu Thr Gln Lys Ser Ser Ser Ser Val Ser Pro Ser Ser Asn Ala 
    450                 455                 460                 


Pro Gly Ser Cys Ser Pro Asp Gly Val Asp Gln Gln Leu Leu Asp Asp 
465                 470                 475                 480 


Phe His Arg Val Thr Lys Gly Gly Ser Thr Glu Asp Ala Ser Gln Tyr 
                485                 490                 495     


Tyr Cys Asp Lys Asn Asp Asn Gly Asp Ser Tyr Leu Val Leu Ile Arg 
            500                 505                 510         


Ile Thr Pro Asp Glu Asp Gly Lys Phe Gly Phe Asn Leu Lys Gly Gly 
        515                 520                 525             


Val Asp Gln Lys Met Pro Leu Val Val Ser Arg Ile Asn Pro Glu Ser 
    530                 535                 540                 


Pro Ala Asp Thr Cys Ile Pro Lys Leu Asn Glu Gly Asp Gln Ile Val 
545                 550                 555                 560 


Leu Ile Asn Gly Arg Asp Ile Ser Glu His Thr His Asp Gln Val Val 
                565                 570                 575     


Met Phe Ile Lys Ala Ser Arg Glu Ser His Ser Arg Glu Leu Ala Leu 
            580                 585                 590         


Val Ile Arg Arg Arg Ala Val Arg Ser Phe Ala Asp Phe Lys Ser Glu 
        595                 600                 605             


Asp Glu Leu Asn Gln Leu Phe Pro Glu Ala Ile Phe Pro Met Cys Pro 
    610                 615                 620                 


Glu Gly Gly Asp Thr Leu Glu Gly Ser Met Ala Gln Leu Lys Lys Gly 
625                 630                 635                 640 


Leu Glu Ser Gly Thr Val Leu Ile Gln Phe Glu Gln Leu Tyr Arg Lys 
                645                 650                 655     


Lys Pro Gly Leu Ala Ile Thr Phe Ala Lys Leu Pro Gln Asn Leu Asp 
            660                 665                 670         


Lys Asn Arg Tyr Lys Asp Val Leu Pro Tyr Asp Thr Thr Arg Val Leu 
        675                 680                 685             


Leu Gln Gly Asn Glu Asp Tyr Ile Asn Ala Ser Tyr Val Asn Met Glu 
    690                 695                 700                 


Ile Pro Ala Ala Asn Leu Val Asn Lys Tyr Ile Ala Thr Gln Gly Pro 
705                 710                 715                 720 


Leu Pro His Thr Cys Ala Gln Phe Trp Gln Val Val Trp Asp Gln Lys 
                725                 730                 735     


Leu Ser Leu Ile Val Met Leu Thr Thr Leu Thr Glu Arg Gly Arg Thr 
            740                 745                 750         


Lys Cys His Gln Tyr Trp Pro Asp Pro Pro Asp Val Met Asn His Gly 
        755                 760                 765             


Gly Phe His Ile Gln Cys Gln Ser Glu Asp Cys Thr Ile Ala Tyr Val 
    770                 775                 780                 


Ser Arg Glu Met Leu Val Thr Asn Thr Gln Thr Gly Glu Glu His Thr 
785                 790                 795                 800 


Val Thr His Leu Gln Tyr Val Ala Trp Pro Asp His Gly Val Pro Asp 
                805                 810                 815     


Asp Ser Ser Asp Phe Leu Glu Phe Val Asn Tyr Val Arg Ser Leu Arg 
            820                 825                 830         


Val Asp Ser Glu Pro Leu Leu Val His Cys Ser Ala Gly Ile Gly Arg 
        835                 840                 845             


Thr Gly Val Leu Val Thr Met Glu Thr Ala Met Cys Leu Thr Glu Arg 
    850                 855                 860                 


Asn Leu Pro Ile Tyr Pro Leu Asp Ile Val Arg Lys Met Arg Asp Gln 
865                 870                 875                 880 


Arg Ala Met Met Val Gln Thr Ser Ser Gln Tyr Lys Phe Val Cys Glu 
                885                 890                 895     


Ala Ile Leu Arg Val Tyr Glu Glu Gly Leu Val Gln Met Leu Asp Pro 
            900                 905                 910         


Ser 
    


<210>  2442
<211>  6866
<212>  DNA
<213>  Homosapiens

<400>  2442
gcagatgcgc tggccccagc ccggggctgc cgctcgcctt cccccggagt ctcctggacc     60

cccggagtct cctggacccc cggagcggga ggcagcggcc gcgcggcgct ggactggagc    120

agaaccccag gactgcgccc ccgggagcgg gcgcccagag aagcctcccc agctttctga    180

ggatgatatc tggctaaaaa gcgagggaga caactatagt gccaccctcc tggagcctgc    240

tgccagctct ctttccccag atcacaaaaa catggaaatt gaggtgtctg ttgcagaatg    300

taaaagtgtt cctggaatca cctctacccc acatcccatg gaccatccct ccgctttcta    360

ttcacccccg cataatggcc tccttactga tcaccacgaa tccctggata atgatgttgc    420

cagagagatc cgctatctag atgaggtgct agaggccaac tgctgtgatt ctgctgtgga    480

tggaacgtac aatggaacat cctccccaga gcctggtgca gtggttctgg tgggcggcct    540

aagcccccct gtccacgagg cgacccagcc agaacccact gaaagaacag ctagccggca    600

ggcacctcct cacatcgagc tcagtaatag cagccctgac cccatggcag aggcagaaag    660

aacaaatggc cattccccca gccagcctag agatgcgctg ggggacagcc tgcaggtgcc    720

tgtcagcccc agctccacaa ccagctcacg gtgttcttcc cgagatggag agttcactct    780

caccacactg aaaaaggagg ccaagtttga gctgcgtgcc ttccatgagg acaagaagcc    840

ctccaagctc tttgaggatg acgagcatga gaaagaacaa tactgcatta gaaaagtgag    900

gccttcagag gagatgctgg agctggaaaa ggagaggaga gagctcatcc gcagccaggc    960

cgtcaagaag aatcctggca ttgcagcaaa atggtggaat cccccgcagg aaaaaaccat   1020

cgaggagcag ctggacgagg aacatctgga gtcgcacaaa aagtacaagg agcgcaaaga   1080

gagaagggca cagcaggaac agttgctgct gcagaagcag ttacagcagc agcagcagca   1140

gcccccatcg cagctctgca cagcccctgc ctcttctcat gaacgcgcaa gcatgattga   1200

caaagcaaag gaggacattg tcacagagca gatagatttc tctgctgctc gcaaacaatt   1260

tcagctgatg gagaattcca ggcaagcggt ggccaagggc cagagtacac ccaggctgtt   1320

ctccatcaag cctttctaca ggcctctggg gtcagtcaac tcagacaagc cactgactaa   1380

tccgagacca ccttctgtcg ggggacctcc agaagacagt ggtgcctcag ccgccaaggg   1440

acagaaatcc cccggtgccc tggagacccc atcggcagca ggaagccagg gcaacacagc   1500

ctctcagggg aaggaagggc cctacagcga gccttctaaa cgtgggccct tatctaaact   1560

gtgggctgag gatggagaat ttacgagcgc ccgggctgtc ctcactgtgg tcaaggatga   1620

tgaccatggg attttggatc agttctcaag atctgtcaat gtctccttga cccaagagga   1680

gcttgactct ggtctggacg aattgtcggt gaggtctcag gataccacag tcctggagac   1740

cctatccaat gatttcagca tggacaacat cagtgacagc ggggcatcca atgagacaac   1800

caatgccctc caggaaaatt cactggctga tttttctctg ccccagacac cacaaactga   1860

caacccctca gagggccgag gagaaggcgt ctccaagtca tttagtgatc atggtttcta   1920

ttccccttcc tccacgctgg gggactctcc gttggttgat gaccccttgg agtatcaggc   1980

tggcctcctg gtgcagaatg ccattcaaca agccatagcc gagcaggtgg ataaagctgt   2040

gtccaaaacc agcagggatg gagcagagca acagggacct gaagcgactg tagaggaagc   2100

tgaagctgcg gctttcggct cagaaaagcc tcagagcatg tttgagccac ctcaggtgtc   2160

ttctcctgtt caagagaaaa gggatgtatt accaaagatt ctgcctgctg aagacagggc   2220

gctcagggaa agggggcccc cccagccact gccagctgtg cagcccagtg gcccgattaa   2280

catggaggag accaggcccg aaggaagcta tttcagcaag tactcggagg cagctgagct   2340

gagaagcaca gcctccctcc tggccactca agaatctgac gtgatggttg ggcctttcaa   2400

gctgaggtcc aggaaacagc ggactttgtc catgattgag gaagagatcc gagcagctca   2460

ggaaagggaa gaggagctga agaggcagag acaagtcttg cagagtacgc agagccccag   2520

gacaaagaat gccccatcac tgccctccag aacatgctac aaaactgctc cagggaaaat   2580

agagaaagtc aaacctcctc catcccccac cactgaaggc cccagcttgc agcctgactt   2640

agcccctgaa gaggctgccg gaacccagcg gcccaagaat ctgatgcaga ccctcatgga   2700

agactatgag acacacaaat ctaaaaggcg cgagagaatg gatgatagta gtgtcctcga   2760

ggccacacgg gttaatcgaa gaaagagcgc actggctttg cgctgggaag cagggatcta   2820

tgccaaccag gaggaagaag acaacgaata aacttccttc aacccaggaa gcgtctttgg   2880

tgcttgggag accaagaaac caagaaatta acaactgaaa gcattttaat ggactattta   2940

ttaaagtgca aacaaactca gcaatcctta tgtagaccag aagctgcaat atacaatgat   3000

gaaaatgaaa cgaaaaggaa gtccccccat cagactctgg acacccagga atcaaaagag   3060

aaaggacttt tttggtgact caatcccagt gtctggtttg gggccaatct acaatggatc   3120

caaaaggaca aaacatgtta caagcaaatc aacatagttg ctgcaggcgg aactgagacc   3180

agcctctctg ggcgatgaag gacaatggtg gtagggccac ttagagagca gtagggccca   3240

ggctggtgca gcctacatgg cacaggatat ttccctgcac cagtttccca cctgtcactt   3300

gcagcatcag agggtgttgc attaactcca ttttctccag cagccataaa atgaatggcg   3360

tttctctcca tatttgccca gaagaggcag ttatgattcc acttctccta catttaatta   3420

tttttaattg agaacaactc atgatcacaa ttcataaaat ccatatttta agacaatagt   3480

tcttcatgtc acaaacacaa tctattctac atgaggaggc tgagaaaggg gaagagaaaa   3540

acaaaccaaa tggatgatgt tagctttagg atcgtgtctg cttataatat tcactgatct   3600

gcagtttatg agaacacatt ttcacagtta tgtttcttca taggaaaact atatttagtg   3660

ggcaacaact atttttatga tgggatgggg gagtatatac acgtatagaa tctgtacgcg   3720

ttgaacaact tggttcaaga tggtgggggc atttttagag cggcaataat tgaaaaaaaa   3780

ggcgaactct gccttggaga ggtagatgat aagaaataaa aaggtgttta taactatttt   3840

gtattataaa gtgggcctta gagataggaa gaagaatgat ggattccttt tggatcaatc   3900

agaaaggaaa cacgaaagaa aagtcaggaa ggtagagaga gaaaaaggga gggaaggaga   3960

aagaatggga ataaaataag gaggtaagag atactatttt tgctgagcaa ccagtgtgtt   4020

tcaggatgat acaaagaaaa atatagaata gaaataagtg caggcttgga atcagctaca   4080

aatcctaaag atggggtgtg tgtggatgtg tgtgtgtgtg tgtgtacacc attgtgtgtt   4140

tgtaaaatgt gtatgttcat gagtaagggt gtgtgtgtgt gtgtattaaa attccagagt   4200

gaccgtggca cttgggtgta caggtaattc ctccagagct gtttgctggc ttcaggagtg   4260

gagtgagaat ttctttttta tgaaaaggga tataaaggca ccgagctgat gcagtatttg   4320

taatattaag ttgacctaac aaggtatttg catgagtcac aattacaaag ttttgagcgg   4380

ttttgtaatt tgacatttag gagagtctcc tatttattct catactttac attcatgctt   4440

agtatactat agaggatgcc agctttaatc tttctgtcat ttaaagcaat atgataaggg   4500

tattcaataa ttgggtgccc taaatttctg gatgagaaaa ttttcaattc tggccatgag   4560

aaagaaaaaa aaataaacag ccttcttttt ttttcctttg ttttaaaact gtggtttttt   4620

aaaaaagcaa taattaactc agacctcact aaaaatcatt tttgttttta tattgttatg   4680

tcataagctc tattatgtta ttctaacaag tagcaatttc acaaaatttg tatgtagatg   4740

ttaacgcaca tttcctttgc ttcttttatt agactagtgt tgactttggg gggggacatt   4800

tattcacaaa tgagaagtag gcacaaagta aaaaatggaa ccatctacta acaaggatcc   4860

tttaaaactg ccaagggagc tctaacttga agccacatcc tacagatggc agcccaaata   4920

gcacatgggc aattggcacc atctttatat ggttgagtct cctgaatatt ttgaatgaat   4980

tctcaacaaa atgtgctagc cactggggac gcaaaacaag taagatccct gttgcaagaa   5040

attcatttta tagtgaggga ggttggcatg gagactaaaa ttctcaggaa aatgagatcc   5100

gtgttagatt agaagtcctg atgtgaaatg ggaggactca ggaaggagga tcgtctttac   5160

ctgaggattt ctagccagag gtcccagatg cctgggctga gaacccagcg ataagggggc   5220

gttcccaaag cagacacagg gataagaaca gaggaggcag cagcattgca cagccccagg   5280

cacagtggca gttaggatgg ctggagagta ggatagttct atgggttgcc caaaaaatgt   5340

gatgcgcttc atgttttctc tgactcatgg atctggtaga gaccatagac atgatataga   5400

ctaacttccc catttttcac aagaggaaac catccttatg acttacctta aagttttttg   5460

ttctgttttg aaggaaacca tgtgcttcat gaaacctaca gttgacaaga gaatgtacag   5520

ctaagagaaa agcttaagag gccacactat tcgcggaatg gctttagagg cagatgaagt   5580

ggtctttgac cacagttgat tgaaccagag cacttattgc ttaaagaata acagagttct   5640

agagctgggg gttcttgggc catgctccgt gtgtggataa ggaaagaaat actgtttctg   5700

ggactctccc acagtcacaa agctgttttc actgtggccc ctacatctct taacttttgc   5760

tattactcct atgctgcctt ccggattact gctgtctatc ttcttgctcc actcactgaa   5820

gatcctatta taatcccatg aaaatgtaaa ttacagttta cttgggagag ccagattttc   5880

tctgtgctct tgagtttttt attcattcaa gaaaccttgg gccaccgctt tgtacatagc   5940

accgtgctag gctctgggat cccaaatgga cccttttaac tttctgaaga tgggaccgtc   6000

ccctggagga aagtcattcc tgcctaatcc atcgagagaa agaggcttac gaaaaacttt   6060

gcctctgatg ctcagcccca cccccaaata gcacacaagc ttgttaaccc cacctcttac   6120

aaaatgttta gattctgtag gtgttaaaag cctttctgga agtattgcat tctgccgtgt   6180

ttataggtgt tcactttcct ccagagctga ttaactactg acatgacttg gctttctcat   6240

ccagaaatta tggaaacagg gtctgtcagt ggcaggaggc cgtgctgtgt tttacttgga   6300

tgacacaatg cagtttactt gcctcttcat acccatgcat gctgctcacc ctagacaatg   6360

acatataagc cgtatataga tcaatgtcca catatatata cacacacaca tatatatata   6420

taaagtgtaa caaggaacac taaaacagtg ttgattcttg tctctgaaga caaataatta   6480

aacctttttt ttcccaacta aagaatggat ttaattaaac tatgtattga aaaaaaagta   6540

gcctaagtgt tagagatggt gaatatattc cattttagtt aaagaacaaa tttcctgaat   6600

tttaagcatt cagtgagctg ccaattttga ttttgtgttg ctctttaccc aaattatttt   6660

ttctttgttt ttcttttttt gggggaggag gggaaaaaag cagcaatact gtgtttggaa   6720

attatactct gtatctggtt ttcctgtgta tgttaaccac ttaaatgtta ttatcctgct   6780

ttggttttag agtgattgtg aggcattcaa tgcaagtata cagttatttt ctcattaaaa   6840

tccaatgtgt gttgagtttt tataaa                                        6866


<210>  2443
<211>  948
<212>  PRT
<213>  Homosapiens

<400>  2443

Met Arg Trp Pro Gln Pro Gly Ala Ala Ala Arg Leu Pro Pro Glu Ser 
1               5                   10                  15      


Pro Gly Pro Pro Glu Ser Pro Gly Pro Pro Glu Arg Glu Ala Ala Ala 
            20                  25                  30          


Ala Arg Arg Trp Thr Gly Ala Glu Pro Gln Asp Cys Ala Pro Gly Ser 
        35                  40                  45              


Gly Arg Pro Glu Lys Pro Pro Gln Leu Ser Glu Asp Asp Ile Trp Leu 
    50                  55                  60                  


Lys Ser Glu Gly Asp Asn Tyr Ser Ala Thr Leu Leu Glu Pro Ala Ala 
65                  70                  75                  80  


Ser Ser Leu Ser Pro Asp His Lys Asn Met Glu Ile Glu Val Ser Val 
                85                  90                  95      


Ala Glu Cys Lys Ser Val Pro Gly Ile Thr Ser Thr Pro His Pro Met 
            100                 105                 110         


Asp His Pro Ser Ala Phe Tyr Ser Pro Pro His Asn Gly Leu Leu Thr 
        115                 120                 125             


Asp His His Glu Ser Leu Asp Asn Asp Val Ala Arg Glu Ile Arg Tyr 
    130                 135                 140                 


Leu Asp Glu Val Leu Glu Ala Asn Cys Cys Asp Ser Ala Val Asp Gly 
145                 150                 155                 160 


Thr Tyr Asn Gly Thr Ser Ser Pro Glu Pro Gly Ala Val Val Leu Val 
                165                 170                 175     


Gly Gly Leu Ser Pro Pro Val His Glu Ala Thr Gln Pro Glu Pro Thr 
            180                 185                 190         


Glu Arg Thr Ala Ser Arg Gln Ala Pro Pro His Ile Glu Leu Ser Asn 
        195                 200                 205             


Ser Ser Pro Asp Pro Met Ala Glu Ala Glu Arg Thr Asn Gly His Ser 
    210                 215                 220                 


Pro Ser Gln Pro Arg Asp Ala Leu Gly Asp Ser Leu Gln Val Pro Val 
225                 230                 235                 240 


Ser Pro Ser Ser Thr Thr Ser Ser Arg Cys Ser Ser Arg Asp Gly Glu 
                245                 250                 255     


Phe Thr Leu Thr Thr Leu Lys Lys Glu Ala Lys Phe Glu Leu Arg Ala 
            260                 265                 270         


Phe His Glu Asp Lys Lys Pro Ser Lys Leu Phe Glu Asp Asp Glu His 
        275                 280                 285             


Glu Lys Glu Gln Tyr Cys Ile Arg Lys Val Arg Pro Ser Glu Glu Met 
    290                 295                 300                 


Leu Glu Leu Glu Lys Glu Arg Arg Glu Leu Ile Arg Ser Gln Ala Val 
305                 310                 315                 320 


Lys Lys Asn Pro Gly Ile Ala Ala Lys Trp Trp Asn Pro Pro Gln Glu 
                325                 330                 335     


Lys Thr Ile Glu Glu Gln Leu Asp Glu Glu His Leu Glu Ser His Lys 
            340                 345                 350         


Lys Tyr Lys Glu Arg Lys Glu Arg Arg Ala Gln Gln Glu Gln Leu Leu 
        355                 360                 365             


Leu Gln Lys Gln Leu Gln Gln Gln Gln Gln Gln Pro Pro Ser Gln Leu 
    370                 375                 380                 


Cys Thr Ala Pro Ala Ser Ser His Glu Arg Ala Ser Met Ile Asp Lys 
385                 390                 395                 400 


Ala Lys Glu Asp Ile Val Thr Glu Gln Ile Asp Phe Ser Ala Ala Arg 
                405                 410                 415     


Lys Gln Phe Gln Leu Met Glu Asn Ser Arg Gln Ala Val Ala Lys Gly 
            420                 425                 430         


Gln Ser Thr Pro Arg Leu Phe Ser Ile Lys Pro Phe Tyr Arg Pro Leu 
        435                 440                 445             


Gly Ser Val Asn Ser Asp Lys Pro Leu Thr Asn Pro Arg Pro Pro Ser 
    450                 455                 460                 


Val Gly Gly Pro Pro Glu Asp Ser Gly Ala Ser Ala Ala Lys Gly Gln 
465                 470                 475                 480 


Lys Ser Pro Gly Ala Leu Glu Thr Pro Ser Ala Ala Gly Ser Gln Gly 
                485                 490                 495     


Asn Thr Ala Ser Gln Gly Lys Glu Gly Pro Tyr Ser Glu Pro Ser Lys 
            500                 505                 510         


Arg Gly Pro Leu Ser Lys Leu Trp Ala Glu Asp Gly Glu Phe Thr Ser 
        515                 520                 525             


Ala Arg Ala Val Leu Thr Val Val Lys Asp Asp Asp His Gly Ile Leu 
    530                 535                 540                 


Asp Gln Phe Ser Arg Ser Val Asn Val Ser Leu Thr Gln Glu Glu Leu 
545                 550                 555                 560 


Asp Ser Gly Leu Asp Glu Leu Ser Val Arg Ser Gln Asp Thr Thr Val 
                565                 570                 575     


Leu Glu Thr Leu Ser Asn Asp Phe Ser Met Asp Asn Ile Ser Asp Ser 
            580                 585                 590         


Gly Ala Ser Asn Glu Thr Thr Asn Ala Leu Gln Glu Asn Ser Leu Ala 
        595                 600                 605             


Asp Phe Ser Leu Pro Gln Thr Pro Gln Thr Asp Asn Pro Ser Glu Gly 
    610                 615                 620                 


Arg Gly Glu Gly Val Ser Lys Ser Phe Ser Asp His Gly Phe Tyr Ser 
625                 630                 635                 640 


Pro Ser Ser Thr Leu Gly Asp Ser Pro Leu Val Asp Asp Pro Leu Glu 
                645                 650                 655     


Tyr Gln Ala Gly Leu Leu Val Gln Asn Ala Ile Gln Gln Ala Ile Ala 
            660                 665                 670         


Glu Gln Val Asp Lys Ala Val Ser Lys Thr Ser Arg Asp Gly Ala Glu 
        675                 680                 685             


Gln Gln Gly Pro Glu Ala Thr Val Glu Glu Ala Glu Ala Ala Ala Phe 
    690                 695                 700                 


Gly Ser Glu Lys Pro Gln Ser Met Phe Glu Pro Pro Gln Val Ser Ser 
705                 710                 715                 720 


Pro Val Gln Glu Lys Arg Asp Val Leu Pro Lys Ile Leu Pro Ala Glu 
                725                 730                 735     


Asp Arg Ala Leu Arg Glu Arg Gly Pro Pro Gln Pro Leu Pro Ala Val 
            740                 745                 750         


Gln Pro Ser Gly Pro Ile Asn Met Glu Glu Thr Arg Pro Glu Gly Ser 
        755                 760                 765             


Tyr Phe Ser Lys Tyr Ser Glu Ala Ala Glu Leu Arg Ser Thr Ala Ser 
    770                 775                 780                 


Leu Leu Ala Thr Gln Glu Ser Asp Val Met Val Gly Pro Phe Lys Leu 
785                 790                 795                 800 


Arg Ser Arg Lys Gln Arg Thr Leu Ser Met Ile Glu Glu Glu Ile Arg 
                805                 810                 815     


Ala Ala Gln Glu Arg Glu Glu Glu Leu Lys Arg Gln Arg Gln Val Leu 
            820                 825                 830         


Gln Ser Thr Gln Ser Pro Arg Thr Lys Asn Ala Pro Ser Leu Pro Ser 
        835                 840                 845             


Arg Thr Cys Tyr Lys Thr Ala Pro Gly Lys Ile Glu Lys Val Lys Pro 
    850                 855                 860                 


Pro Pro Ser Pro Thr Thr Glu Gly Pro Ser Leu Gln Pro Asp Leu Ala 
865                 870                 875                 880 


Pro Glu Glu Ala Ala Gly Thr Gln Arg Pro Lys Asn Leu Met Gln Thr 
                885                 890                 895     


Leu Met Glu Asp Tyr Glu Thr His Lys Ser Lys Arg Arg Glu Arg Met 
            900                 905                 910         


Asp Asp Ser Ser Val Leu Glu Ala Thr Arg Val Asn Arg Arg Lys Ser 
        915                 920                 925             


Ala Leu Ala Leu Arg Trp Glu Ala Gly Ile Tyr Ala Asn Gln Glu Glu 
    930                 935                 940                 


Glu Asp Asn Glu 
945             


<210>  2444
<211>  2162
<212>  DNA
<213>  Homosapiens

<400>  2444
tcccctcccc aggtcctgcc ccacccagct gtgtttgctt ttctcccgga tccggatgga     60

ggggttgccc tgcccgtgcc cagccctgcc ccacttctgg cagcttaggt ctcacttaat    120

ggctgagggc tccaggactc aggcccctgg gaaagggccc ccactcagca tccagttcct    180

gcgagcccag tatgaaggct tgaagaggca gcagaggacc caggcccacc tcctggtgct    240

tccaaaagga ggaaacacac ctgctcctgc agaatcgatg gtcaatgctg tttggattaa    300

caaggagaga agaagctcac tgtccctgga agaggcagat tctgaggtgg aggggaggct    360

ggaggaggct gcccagggct gccttcaggc ccccaagtct ccatggcaca cgcacctgga    420

gatgcattgt ttggtccaaa cctcccccca ggacaccagt catcaagtac atcatagggg    480

caagcttgtg ggatctgatc aaaggctccc tcctgaagga gacacacact tgtttgaaac    540

caatcagatg actcagcaag gaaccggaat cccagaggct gcccagcttc catgccaggt    600

gggcaatacc caaacaaagg cagtggaatc tggcttaaaa ttcagcactc aatgtcctct    660

ttccataaag aacccacaca ggtctggcaa accagcttac tatccatttc cccagaggaa    720

aacacccagg atctcccaag ctgcccggaa cctgggctta tatggctcag cgtgaagctt    780

tctattctgc cagatgtctt gaccttgagg ccacctatgg ccttatagaa gaaccaagga    840

ggcagagcca caacgaggtc tctagctatg agcaagaact ggactaacct aattatagga    900

attgtgggag acgaacttca caatggtaac atggttttac ccttccaata agaagagact    960

tcccaggcca aattgcccac agtttaggat gaagaggact gtctggtcag tgcagcccca   1020

ttctgacatt actatgaggt cctggatatc cattccttgg ggaggaccag taagacatct   1080

gctccatccc tggaactgga taattttgga acataaacca gggacctagc caacagaatg   1140

ccttagcaat gcccaggggt caatgggcgt ggcattcttg ttttcaatgt cttctgatga   1200

tttctcatat attctggaga agacaagctc tgagaattca gatgcttttt ctggtggcta   1260

tgtctggggg gccatctcac ttagaagtca caacactcat tggcagtgat cacatcattt   1320

caatttgggc ttcccaaagt atggtcaccc agggtatgaa ggtgagatca atgctaccta   1380

ccattttgtg tctttaaggg gtctttagaa agggctaatc atctgtcact gctcactgag   1440

acatgtacat tccagcatca tcacagagtt atctccttcc ttccttcctt ccttccttcc   1500

ttccttcctt ctgtctctcc ctccctccct cccttcctcc cttctttcct tctttctttc   1560

ctctcttcct tcttgccttc tttcctgcct tcctgcctat cttttctctc tctctctctc   1620

tgcaaattaa gttcttatta aaaactgcca atcattgacg atatataatg atgagatcct   1680

gaacaaaaga ggcaaagaaa tgctcctact tgaaaaatac acattcccta tagactgcct   1740

cctgtttagt ccaacttaga tcactcagat ccttcctggg atcaaatata tttttaaacc   1800

taagacaaag cgaagcaggt gtcacttggg tgatagggaa aaaagcttgt atttcctggt   1860

taatgtttag cttttgtaat gctatttaaa cacacctaag gtgcctttcc ctcatctcag   1920

gtgctttctc tgtaaagttt cactcccacc tttcttttct ctgcatggcc gtccagtctt   1980

gcccatctac atccagagct gttaactagt agtgtcatta cctgtgaaaa acatgtagaa   2040

gcttccttga accacccaga aatccactca aatttgggga ttgtcattcc ttttgtgaat   2100

aattaataca attcagttgt tttttaaata ttctaataaa aaaggaaatt ttctcaaaaa   2160

aa                                                                  2162


<210>  2445
<211>  218
<212>  PRT
<213>  Homosapiens

<400>  2445

Met Ala Glu Gly Ser Arg Thr Gln Ala Pro Gly Lys Gly Pro Pro Leu 
1               5                   10                  15      


Ser Ile Gln Phe Leu Arg Ala Gln Tyr Glu Gly Leu Lys Arg Gln Gln 
            20                  25                  30          


Arg Thr Gln Ala His Leu Leu Val Leu Pro Lys Gly Gly Asn Thr Pro 
        35                  40                  45              


Ala Pro Ala Glu Ser Met Val Asn Ala Val Trp Ile Asn Lys Glu Arg 
    50                  55                  60                  


Arg Ser Ser Leu Ser Leu Glu Glu Ala Asp Ser Glu Val Glu Gly Arg 
65                  70                  75                  80  


Leu Glu Glu Ala Ala Gln Gly Cys Leu Gln Ala Pro Lys Ser Pro Trp 
                85                  90                  95      


His Thr His Leu Glu Met His Cys Leu Val Gln Thr Ser Pro Gln Asp 
            100                 105                 110         


Thr Ser His Gln Val His His Arg Gly Lys Leu Val Gly Ser Asp Gln 
        115                 120                 125             


Arg Leu Pro Pro Glu Gly Asp Thr His Leu Phe Glu Thr Asn Gln Met 
    130                 135                 140                 


Thr Gln Gln Gly Thr Gly Ile Pro Glu Ala Ala Gln Leu Pro Cys Gln 
145                 150                 155                 160 


Val Gly Asn Thr Gln Thr Lys Ala Val Glu Ser Gly Leu Lys Phe Ser 
                165                 170                 175     


Thr Gln Cys Pro Leu Ser Ile Lys Asn Pro His Arg Ser Gly Lys Pro 
            180                 185                 190         


Ala Tyr Tyr Pro Phe Pro Gln Arg Lys Thr Pro Arg Ile Ser Gln Ala 
        195                 200                 205             


Ala Arg Asn Leu Gly Leu Tyr Gly Ser Ala 
    210                 215             


<210>  2446
<211>  508
<212>  DNA
<213>  Homosapiens

<400>  2446
tttggtgctt tggatccatt tccatcggtc cttacagccg ctcgtcagac tccagcagcc     60

aagatggtga agcagatcga gagcaagact gcttttcagg aagccttgga cgctgcaggt    120

gataaacttg tagtagttga cttctcagcc acgtggtgtg ggccttgcaa aatgatcaag    180

cctttctttc attccctctc tgaaaagtat tccaacgtga tattccttga agtagatgtg    240

gatgactgtc aggatgttgc ttcagagtgt gaagtcaaat gcatgccaac attccagttt    300

tttaagaagg gacaaaaggt gggtgaattt tctggagcca ataaggaaaa gcttgaagcc    360

accattaatg aattagtcta atcatgtttt ctgaaaatat aaccagccat tggctattta    420

aaacttgtaa tttttttaat ttacaaaaat ataaaatatg aagacataaa cccagttgcc    480

atctgcgtga caataaaaca ttaatgct                                       508


<210>  2447
<211>  105
<212>  PRT
<213>  Homosapiens

<400>  2447

Met Val Lys Gln Ile Glu Ser Lys Thr Ala Phe Gln Glu Ala Leu Asp 
1               5                   10                  15      


Ala Ala Gly Asp Lys Leu Val Val Val Asp Phe Ser Ala Thr Trp Cys 
            20                  25                  30          


Gly Pro Cys Lys Met Ile Lys Pro Phe Phe His Ser Leu Ser Glu Lys 
        35                  40                  45              


Tyr Ser Asn Val Ile Phe Leu Glu Val Asp Val Asp Asp Cys Gln Asp 
    50                  55                  60                  


Val Ala Ser Glu Cys Glu Val Lys Cys Met Pro Thr Phe Gln Phe Phe 
65                  70                  75                  80  


Lys Lys Gly Gln Lys Val Gly Glu Phe Ser Gly Ala Asn Lys Glu Lys 
                85                  90                  95      


Leu Glu Ala Thr Ile Asn Glu Leu Val 
            100                 105 


<210>  2448
<211>  480
<212>  DNA
<213>  Homosapiens

<400>  2448
agaattcggc acgaggcctg gtgtaatcat ggtacagatt attaaagaca cgaatgaatt     60

taaaacattt ttgacagctg ccggacacaa actcgcagtg gttcaatttt cttcgaaacg    120

gtgtggtccc tgcaaaagga tgtttcctgt tttccatgct atgtctgtga aataccaaaa    180

tgtatttttt gctaatgtgg atgtgaacaa ttctccggag ctggctgaaa cttgtcacat    240

caaaacaata cccacatttc agatgttcaa gaaaagccag aaggtaaccc tattctcaag    300

aatcaaaaga ataatttgct gttatagaag tggattcatg agcaacctgt gtcttgcaga    360

tgatggaaat gagtaggatt taacttttca atcaggaata aaattcctta aagcctcaac    420

attttcgcag cacttgaatc aataaatgtt tcacctttgt gcatttgtga aaaaaaaaaa    480


<210>  2449
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  2449

Met Val Gln Ile Ile Lys Asp Thr Asn Glu Phe Lys Thr Phe Leu Thr 
1               5                   10                  15      


Ala Ala Gly His Lys Leu Ala Val Val Gln Phe Ser Ser Lys Arg Cys 
            20                  25                  30          


Gly Pro Cys Lys Arg Met Phe Pro Val Phe His Ala Met Ser Val Lys 
        35                  40                  45              


Tyr Gln Asn Val Phe Phe Ala Asn Val Asp Val Asn Asn Ser Pro Glu 
    50                  55                  60                  


Leu Ala Glu Thr Cys His Ile Lys Thr Ile Pro Thr Phe Gln Met Phe 
65                  70                  75                  80  


Lys Lys Ser Gln Lys Val Thr Leu Phe Ser Arg Ile Lys Arg Ile Ile 
                85                  90                  95      


Cys Cys Tyr Arg Ser Gly Phe Met Ser Asn Leu Cys Leu Ala Asp Asp 
            100                 105                 110         


Gly Asn Glu 
        115 


<210>  2450
<211>  2752
<212>  DNA
<213>  Homosapiens

<400>  2450
cgctaaggcc gccctccggg tagccgccat gtcggtctcc agcggcgtcc agattctgac     60

aaagccagag accgtggacc ggaggagaag tgcggaaacg accaaagagg ccgggcgacc    120

actggagatg gctgtgtccg agcccgaggc cagcgccgcg gaatggaagc aactggatcc    180

tgctcagagc aacctgtata atgatgtgat gctggagaac tactgcaacc aagcctcaat    240

ggggtgtcaa gctcccaaac cagacatgat ctccaagttg gaaaaaggag aagcaccatg    300

gttggggaag gggaaaagac ccagtcaagg ttgtccaagt aaaatagcaa gacccaagca    360

aaaagaaact gatggaaaag tccagaaaga tgatgaccag cttgaaaata tccagaaatc    420

tcaaaacaaa ctcctcaggg aagttgcagt caagaagaaa actcaagcta agaagaatgg    480

cagtgactgt ggttcactgg ggaaaaaaaa taatttgcat aaaaaacatg ttccttcaaa    540

gaaaaggctt cttaaatttg agtcatgtgg aaaaattttg aaacagaatt tagatttacc    600

tgatcactca agaaactgtg taaaaaggaa atctgatgca gctaaagaac acaagaagtc    660

attcaaccat agcttatctg atacaaggaa aggcaaaaag caaactggaa agaaacatga    720

gaaattatcc agccatagct catctgataa gtgtaacaaa actggcaaaa aacatgacaa    780

attatgctgt catagttcat cccatattaa acaggacaaa attcaaactg gagagaaaca    840

tgagaaatca cccagcctta gctcatctac taagcatgaa aaacctcaag cttgtgtgaa    900

accctatgaa tgtaatcaat gtggaaaggt tctcagccat aaacaaggac tcattgacca    960

tcagagagtt catactgggg agaaaccata tgaatgtaat gaatgtggga tagcctttag   1020

ccaaaagtca caccttgttg tacatcagag aactcacacc ggagaaaaac catatgaatg   1080

tattcagtgt ggcaaagccc atggtcataa acatgcactc actgaccatc taagaattca   1140

tactggagaa aagccctatg aatgtgctga atgtgggaaa accttcagac acagctcaaa   1200

ccttattcaa catgtgagat ctcacacagg tgagaagcca tatgaatgta aggaatgtgg   1260

gaagtctttt aggtataact catctcttac cgaacatgtg agaacacata caggtgaaat   1320

accatatgaa tgcaatgaat gtggaaaagc ctttaagtat agctcatccc ttactaaaca   1380

catgagaatt catacaggtg agaaaccctt tgaatgtaat gaatgtggga aagctttcag   1440

caagaagtca cacctcatta tacatcaaag aactcatact aaggagaaac cttataaatg   1500

taatgagtgt ggaaaagcct ttggacatag ctcatctctt acttaccata tgagaactca   1560

tacaggtgaa agtccctttg aatgtaatca atgtgggaaa ggctttaaac aaattgaagg   1620

ccttactcaa catcagagag ttcatactgg agagaaaccg tatgagtgta atgaatgtgg   1680

gaaagccttt agccaaaagt ctcacctcat tgtacatcag agaactcata ctggggagaa   1740

accttatgaa tgtaacgaat gtgaaaaagc ctttaatgca aaatcacagc ttgttataca   1800

tcagcgatcc cacactggag aaaaacccta tgaatgtaat gaatgtggga aaactttcaa   1860

acaaaatgca tccctaacca aacatgtgaa aactcattca gaagataaat ctcatgagtg   1920

aagttaatgt gggaaatttg ttaactaaat ttaaggtttt gttgaacctt ggaaatatgc   1980

tgattttaaa gagtgttaga aagcctttag caagatgtca caccttgttg tacatgagaa   2040

actttgaaaa tggatcttca tatagaatca gtggatggaa acaagggttt aaacttgata   2100

caaaaccttt tataaaaaat attgttttaa ctactcaatt attataaatg atctacatgt   2160

tcagattgaa attgaaagct ttaaaaattg tgaattattt gaatattcaa agcaatggag   2220

aaacaagtta tatatgctga cagttcctgt gtttcttctt gttttgtact taagcaccat   2280

atattagagt tgaatttgca tatctgttta ttgccttatg taaatgagtg tggccatctg   2340

tataagcctc tttgacattt tcacccagct ctttcttaat gtctgtgttg gcttctgcat   2400

cagcagaaat ctttttaaaa gggttgttat atatgtaaaa aatgttaaca ggaaaatgag   2460

agaaaataaa gcagctgagg atacaaatgt gctggtaggg agcgatattc aagatatatt   2520

gtgaagtgtg aaaaagtagg ttgctgaacc atgtatatag tatgttcccc tttgtgtaca   2580

aaagggtatg tttgtttaac ctctgtctct tatctctgta tgtgtatgta tctttgtatg   2640

catatataca tgtatctgta tgtgaataga ctttgaaaaa atacagaata aacttcatgg   2700

tggttgccat tgggcagagg agtataggac tggggtctag gataggagca ag           2752


<210>  2451
<211>  630
<212>  PRT
<213>  Homosapiens

<400>  2451

Met Ser Val Ser Ser Gly Val Gln Ile Leu Thr Lys Pro Glu Thr Val 
1               5                   10                  15      


Asp Arg Arg Arg Ser Ala Glu Thr Thr Lys Glu Ala Gly Arg Pro Leu 
            20                  25                  30          


Glu Met Ala Val Ser Glu Pro Glu Ala Ser Ala Ala Glu Trp Lys Gln 
        35                  40                  45              


Leu Asp Pro Ala Gln Ser Asn Leu Tyr Asn Asp Val Met Leu Glu Asn 
    50                  55                  60                  


Tyr Cys Asn Gln Ala Ser Met Gly Cys Gln Ala Pro Lys Pro Asp Met 
65                  70                  75                  80  


Ile Ser Lys Leu Glu Lys Gly Glu Ala Pro Trp Leu Gly Lys Gly Lys 
                85                  90                  95      


Arg Pro Ser Gln Gly Cys Pro Ser Lys Ile Ala Arg Pro Lys Gln Lys 
            100                 105                 110         


Glu Thr Asp Gly Lys Val Gln Lys Asp Asp Asp Gln Leu Glu Asn Ile 
        115                 120                 125             


Gln Lys Ser Gln Asn Lys Leu Leu Arg Glu Val Ala Val Lys Lys Lys 
    130                 135                 140                 


Thr Gln Ala Lys Lys Asn Gly Ser Asp Cys Gly Ser Leu Gly Lys Lys 
145                 150                 155                 160 


Asn Asn Leu His Lys Lys His Val Pro Ser Lys Lys Arg Leu Leu Lys 
                165                 170                 175     


Phe Glu Ser Cys Gly Lys Ile Leu Lys Gln Asn Leu Asp Leu Pro Asp 
            180                 185                 190         


His Ser Arg Asn Cys Val Lys Arg Lys Ser Asp Ala Ala Lys Glu His 
        195                 200                 205             


Lys Lys Ser Phe Asn His Ser Leu Ser Asp Thr Arg Lys Gly Lys Lys 
    210                 215                 220                 


Gln Thr Gly Lys Lys His Glu Lys Leu Ser Ser His Ser Ser Ser Asp 
225                 230                 235                 240 


Lys Cys Asn Lys Thr Gly Lys Lys His Asp Lys Leu Cys Cys His Ser 
                245                 250                 255     


Ser Ser His Ile Lys Gln Asp Lys Ile Gln Thr Gly Glu Lys His Glu 
            260                 265                 270         


Lys Ser Pro Ser Leu Ser Ser Ser Thr Lys His Glu Lys Pro Gln Ala 
        275                 280                 285             


Cys Val Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys Val Leu Ser His 
    290                 295                 300                 


Lys Gln Gly Leu Ile Asp His Gln Arg Val His Thr Gly Glu Lys Pro 
305                 310                 315                 320 


Tyr Glu Cys Asn Glu Cys Gly Ile Ala Phe Ser Gln Lys Ser His Leu 
                325                 330                 335     


Val Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Ile 
            340                 345                 350         


Gln Cys Gly Lys Ala His Gly His Lys His Ala Leu Thr Asp His Leu 
        355                 360                 365             


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ala Glu Cys Gly Lys 
    370                 375                 380                 


Thr Phe Arg His Ser Ser Asn Leu Ile Gln His Val Arg Ser His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ser Phe Arg Tyr 
                405                 410                 415     


Asn Ser Ser Leu Thr Glu His Val Arg Thr His Thr Gly Glu Ile Pro 
            420                 425                 430         


Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Lys Tyr Ser Ser Ser Leu 
        435                 440                 445             


Thr Lys His Met Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Asn 
    450                 455                 460                 


Glu Cys Gly Lys Ala Phe Ser Lys Lys Ser His Leu Ile Ile His Gln 
465                 470                 475                 480 


Arg Thr His Thr Lys Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys 
                485                 490                 495     


Ala Phe Gly His Ser Ser Ser Leu Thr Tyr His Met Arg Thr His Thr 
            500                 505                 510         


Gly Glu Ser Pro Phe Glu Cys Asn Gln Cys Gly Lys Gly Phe Lys Gln 
        515                 520                 525             


Ile Glu Gly Leu Thr Gln His Gln Arg Val His Thr Gly Glu Lys Pro 
    530                 535                 540                 


Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser His Leu 
545                 550                 555                 560 


Ile Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn 
                565                 570                 575     


Glu Cys Glu Lys Ala Phe Asn Ala Lys Ser Gln Leu Val Ile His Gln 
            580                 585                 590         


Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys 
        595                 600                 605             


Thr Phe Lys Gln Asn Ala Ser Leu Thr Lys His Val Lys Thr His Ser 
    610                 615                 620                 


Glu Asp Lys Ser His Glu 
625                 630 


<210>  2452
<211>  5770
<212>  DNA
<213>  Homosapiens

<400>  2452
atgtcagcga ttccgggaga gcccgcgagg gggcgagcga ccaccgctcg gccgcgagct     60

cagcgcttcc ctcgccgctt cccaacggcc agcagagggc gcgcgcctgg cgctgagccc    120

aaccgccgcc tccaacggga ctggaccaga ccgggtggga ccggaccgcg gtttgagtcc    180

aagcccagcg gtgtttgcgg cgggtccggg gcctggaagc gcgggggcgg cgccgagaac    240

gaaactggaa aatggccttc attggaaaag ccccagtcct cggggagcag atcccccatc    300

tctggcagtg cagtgtgcct gggagctgtc tggaacattc cgcaacggtc actcctctgc    360

cctgcattgg ccttgaccac atgacccaga ggtgcaggga gaagcctccc ttggatgctt    420

ggagtgactt cagctgctga gagtgtctaa ggagagccgg gaacaccgca cgcttcctgc    480

agatggcggg gcagacctgt gtgcaagagt gcctgaaggg gatctcccgt ggcgctacct    540

ggtccaggga ggtcacagag agctcctcca ccctgagcac agggggtccc accaaggaca    600

aggacaagat tcagcaccgt cgcacacaga acagctacct ggagccacag gtcactttcc    660

aaaaagggag tttccaggcc agaagccatc cctgcagcat tgtctttgtg ctccaagaga    720

agccctggca cacacttctg ctcagatgga accactgttc cctcagtgtc cttgtcagta    780

ccagctggtg actttcctac tcaaaccctt ccctcactct ctgcctcatt ttctcaaggt    840

gccgtgtttg cctgaaagga cattggcagc cagcaggggc ggcggctggt cctctagatg    900

ggcacgaatg ccattggcag gcaatggggc agactccatg gaaagatgct tctcttcctc    960

aaggtatgca ctcagcgggg agacctcatt gtcaagttca gagttacgct gcagactgca   1020

cagcacctcg cctgcttcta gggcctgctc cggtcagccc aggacccacc acagcaggac   1080

cccccatcct gtgctcaccc ggggcttgtc catggcactg gaaactcctt cctgttcctg   1140

atccccctct gggcgagggg tgggcaggga catgtggctc gtgccgaggt ctaatactgt   1200

gttcccagca tggaagcagg tggggacact tcctgtggca tgcaggattc cgtgtagaaa   1260

gctgtgactg tcacccctcc tccccactca gttttgttag tggacctttc cctggccctt   1320

ctctccttgg ccccctcttg gcaggagaga ggaggagagg atctcacttt ccccctgtac   1380

cagccacacc ctcggtctgc ggggttccca gcagctggcc agggatgctc cacacctgga   1440

ggtcaagtaa ccgtcccctc actctgggca tcggtgccct ctctggggtt ggaacaggaa   1500

agaaagccaa gacctgtatg tgggacttga gttgagactc aattctgtag agtcaggggt   1560

gaggaggagc caggcctcct gtgtgctctc cataccccag agccgggtgc ccagttccat   1620

gggtcctgat ggacagaagg gaagaacggg ggggctgctg caccgtgggt ggtaatgcag   1680

tgggagccac ctccagctga atgcccaggg actcctgggg ctgctggccc cgggtcccag   1740

cagtgggtcc tgtttcttct ttactcttgg aatgcaggat ctgccacacc aaaacgtccc   1800

ctccacattt ggtgaaatag gaagctccat ggcatgtctc catctttcaa ggtgactgag   1860

aggtttattt tcataggagc ctcagtggcc ttgtccgtac ccacctctgc acgtggttgc   1920

agaaagtgaa ggattgtcag ggagcagggc agacatttgg tttatctgtg tcattggtca   1980

aagttttgtt tttcctccag aagaaaaagg cttgtgaaca tgccaccgta ttcttcattc   2040

cttcttttgg aaatgtatga agaacgggtg gcattttgga gttattggcc tgtgaacagc   2100

tggcccagag gaagggttag atgtgggtgg gtgtggccgc ctctgcccct ccccagcgca   2160

ggtgtgcgtg ggcagcccag gcaggcgctc aggaagggtg aggtggagcc ctgcacgctc   2220

tgagcacaaa gtcctgggat cccttaaacc caagcactgc cttgacagca gccagcatgg   2280

ctgatagaag agacacagaa gtccagctga tgccagacag agggcgtcac tagagagccg   2340

tgctaggtgg gggtcattca agttgtcttg gcgtatgcag acgttgcttc tagagagtca   2400

gaagctctat atgcgtagtg ttggagcaga atttcgggat agtgatggca agcctcctcc   2460

caagccagct ggggagtatg gggagggggt ggccggagga acctggcatc cccgggttag   2520

gaccacagag gtggctctgc ctgcagctgg gcctctgcct catcctgact ccccctgctt   2580

tggccatggc tcttcttgtc cttcctcttc tcagtgcagg aggaccctga atcaaatgcc   2640

tcatcctggt ttgcatttta ccctcggatg aagcttgtgg cgaacccctg gactctgtgt   2700

ctcctgagtc tctgcagacc tcgggtcctg gacccagaga ctcttctccc tgggacagga   2760

ggcactgggg tgggtggaca ggggtggcct ggggcacagt agctgacggg gggacttcct   2820

agttttctgg gcctttccaa ctctgagtgt gaccttccta ttcttgatca cagcccccaa   2880

cttcggagcc tgctagagcc tgcagaatgt ggcttcatcc tcttcctctg tgggaaaagg   2940

cggggcctgg cagtcccgcc aatcttgtat atttgctccc cacctcggtg gtgaatacat   3000

tcttgggtgg tgaataggtt ctctccttgc cttcactcta gaaaagtccc ctgttttgtg   3060

atgtaggatg tggtcaatga ctgactcgtc cctttggacc atagacgcag ctctgatttc   3120

tggtgttcct gggctctgca cacagcagga gccactctgg gctctgagag gtgcatcttc   3180

tggctcactt tcttcttgtt ggctcttctc cctgcgtctt ctgccactgc cctgttctgg   3240

gtgggaggct gtcacactgt ggtggagggt cccctctcct gcctcccctc tttgatcctt   3300

ttctgtgagg gtctgctggg gtcctgtgtg tcgtgcattg ttgatagatt cctgtcgtgc   3360

ttgctgtcct ccccattcta agggacctct gattgcctgt gagcagttta cagggtcctc   3420

tcctggcccc ttcacccgag gaattcccgc aacgcatgag tttgtgaggg gcggatcctg   3480

ggaggatgtg acgtcaggtg agaagggagg gcccgtccta gtccggtggg ctcctctaac   3540

aaagtgcatt agcctgggga gttactgacg ctcgaaatat gtcgtcaaag ttctgaaggc   3600

tgagaagtcc gagatcaaga tgcctgagga ttcagtgcct ggtgaggacc cattccttag   3660

ggcagtgcct ctagctgtgt cctcatgtgg ccgaagggga caagggaggt tgctggagcc   3720

tgtttgatga gagcactacc ttccttcagg aggggattat tcagaaagtc tgtctggttt   3780

cagggcattc ccaaaggccc cacctgttca ttctacccca ttggtagaat tcccattggg   3840

aattaggctt caacatacaa atttgggaga cactgacatt taggccatag cgcgtcaaag   3900

gcaaagtgag gctgagtgtg gaaaccatcc cagaatctgg atgtggccca ggcagaagga   3960

aactcaaagt gatggggtga ccgatggtcc ctggtctgtg caggactcag cggtgcggat   4020

ggccctgggc acggtggcag tggctgttgg aggatgatag ggaacatgtt ggtgggggga   4080

gggtggagcc cactatgagt ggcaactccc tgggggcaca ggaaacaaag ctagaggtgg   4140

ctcccctctc ccctccctgc acacagtgtc acctctgtgg tggccctgtc gtccgcctca   4200

gttcacaggt gttgctgtaa caactcctga aattaccttc aaaaggaggc tcgtgcaggt   4260

gcctgcagga gccaggaggc cgaagtgcat cctgagtgtc cggggacagg ccagcctggc   4320

ggggtccacg gccccacagt cccaacgact gcctcagaaa tgggcagaga gcatgcctgg   4380

ttctagctgg caaggcccac atctcagagc tgtggacagt catgaagggt ccgtgagcat   4440

ggagaggggg caaaaatgac ccatgaacct caggccactg tgctgccatc cagccaagtg   4500

cggtaccagc ccttcgggcc tcgagatcct ctacccttct ctgggccttg ctgatttcct   4560

cctccagccc ctctgtttgt gtacgcacat acacacatgc acgcacgcac acgcacaccc   4620

agtgcaattt ctctctgctc cctgtactcc ccaaaattca atgggttcct ctttcctcct   4680

cagagatata gtcctgggcc ccatctcagc ctgcagaggc ctgaacgttt cccaggattg   4740

tcttctaatt ctcaggtccg gctttaaaac aaaacctaaa ctaaaactaa aatgctttct   4800

gcaaagaata atacaccaac ataaagtccg ggtatcctaa gcatgtggtg tgtatggtgt   4860

ctgaaattga atatgctgtg aaactgcctg tgtcgaaatg cagtgtttcc caagacctgg   4920

aggctctctc cagctgctga ttgtgatcac ctctcccgat caccgctgag ccctgcaggt   4980

caccttctcc tgacctatta caccactgat tgcttatgct gggcacaatt ttataccctt   5040

gctgttgttc agtctaatca tccctataac cctatcggat cattcccata tgacagagga   5100

gaaaacctgg ggacacaggg gctgtgtcct ggccaaggcc ttgcttgcag caaaaggcag   5160

agctggggtc tagccaggag ccccagcaca gtcctgttct tcccccacta aactgagctg   5220

tgaaatagat catggcagtt tggaaaacgg gctaactgta tgctgaggga ggtggtgacg   5280

gatacctact tcttttcatg ggaaggtgag gtgtctccct gcccccctca ggtctagcct   5340

ctctctgtag ctcagaacct tgggaaagtg ggaggctcag aggaggaaag agatttactt   5400

gcccaagggc cgcagctgct aagtggcagg taagggactg ttattctcct gtccctttca   5460

cagaggacag gaggaaagtg aggacaggtg gtgtacatgc atcttttctg cagcaggccc   5520

agatcagctt tgcacatggt gctgacctca aattcagccc tagaggggcc tgtctctgcc   5580

ctgagtgagt attgaagtgc aggcttcttc ccctttgttc tgtccatttc caaaaatgtg   5640

aacacacacc tccaacatgt ttctgtgtat attattgtgt gcatagatac taccattgtg   5700

aaatattatg cagattaata atgcactatg ccattgaaaa tttcaaaaga aatgtgtaat   5760

gaacatttaa                                                          5770


<210>  2453
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  2453

Met Ser Ala Ile Pro Gly Glu Pro Ala Arg Gly Arg Ala Thr Thr Ala 
1               5                   10                  15      


Arg Pro Arg Ala Gln Arg Phe Pro Arg Arg Phe Pro Thr Ala Ser Arg 
            20                  25                  30          


Gly Arg Ala Pro Gly Ala Glu Pro Asn Arg Arg Leu Gln Arg Asp Trp 
        35                  40                  45              


Thr Arg Pro Gly Gly Thr Gly Pro Arg Phe Glu Ser Lys Pro Ser Gly 
    50                  55                  60                  


Val Cys Gly Gly Ser Gly Ala Trp Lys Arg Gly Gly Gly Ala Glu Asn 
65                  70                  75                  80  


Glu Thr Gly Lys Trp Pro Ser Leu Glu Lys Pro Gln Ser Ser Gly Ser 
                85                  90                  95      


Arg Ser Pro Ile Ser Gly Ser Ala Val Cys Leu Gly Ala Val Trp Asn 
            100                 105                 110         


Ile Pro Gln Arg Ser Leu Leu Cys Pro Ala Leu Ala Leu Thr Thr 
        115                 120                 125         


<210>  2454
<211>  5768
<212>  DNA
<213>  Homosapiens

<400>  2454
atgtcagcga ttccgggaga gcccgcgagg gggcgagcga ccaccgctcg gccgcgagct     60

cagcgcttcc ctcgccgctt cccaacggcc agcagagggc gcgcgcctgg cgctgagccc    120

aaccgccgcc tccaacggga ctggaccaga ccgggtggga ccggaccgcg gtttgagtcc    180

aagcccagcg gtgtttgcgg cgggtccggg gcctggaagc gcgggggcgg cgccgagaac    240

gaaactggaa aatggccttc attggaaaag ccccagtcct cggggagcag atcccccatc    300

tctggcagtg cagtgtgcct gggagctgtc tggaacattc cgcaacggtc actcctctgc    360

cctgcattgg ccttgaccac atgacccaga ggtgcaggga gaagcctccc ttggatgctt    420

ggagtgactt cagctgctga gagtgtctaa ggagagccgg gaacaccgca cgcttcctgc    480

agatggcggg gcagacctgt gtgcaagagt gcctgaaggg gatctcccgt ggcgctacct    540

ggtccaggga ggtcacagag agctcctcca ccctgagcac agggggtccc accaaggaca    600

aggacaagat tcagcaccgt cgcacacaga acagctacct ggagccacag gtcactttcc    660

aaaaagggag tttccaggcc agaagccatc cctgcagcat tgtctttgtg ctccaagaga    720

agccctggca cacacttctg ctcagatgga accactgttc cctcagtgtc cttgtcagta    780

ccagctggtg actttcctac tcaaaccctt ccctcactct ctgcctcatt ttctcaaggt    840

gccgtgtttg cctgaaagga cattggcagc cagcaggggc ggcggctggt cctctagatg    900

ggcacgaatg ccattggcag gcaatggggc agactccatg gaaagatgct tctcttcctc    960

aaggtatgca ctcagcgggg agacctcatt gtcaagttca gagttacgct gcagactgca   1020

cagcacctcg cctgcttcta gggcctgctc cggtcagccc aggacccacc acagcaggac   1080

cccccatcct gtgctcaccc ggggcttgtc catggcactg gaaactcctt cctgttcctg   1140

atccccctct gggcgagggg tgggcaggga catgtggctc gtgccgaggt ctaatactgt   1200

gttcccagca tggaagcagg tggggacact tcctgtggca tgcaggattc cgtgtagaaa   1260

gctgtgactg tcacccctcc tccccactca gttttgttag tggacctttc cctggccctt   1320

ctctccttgg ccccctcttg gcaggagaga ggaggagagg atctcacttt ccccctgtac   1380

cagccacacc ctcggtctgc ggggttccca gcagctggcc agggatgctc cacacctgga   1440

ggtcaagtaa ccgtcccctc actctgggca tcggtgccct ctctggggtt ggaacaggaa   1500

agaaagccaa gacctgtatg tgggacttga gttgagactc aattctgtag agtcaggggt   1560

gaggaggagc caggcctcct gtgtgctctc cataccccag agccgggtgc ccagttccat   1620

gggtcctgat ggacagaagg gaagaacggg ggggctgctg caccgtgggt ggtaatgcag   1680

tgggagccac ctccagctga atgcccaggg actcctgggg ctgctggccc cgggtcccag   1740

cagtgggtcc tgtttcttct ttactcttgg aatgcaggat ctgccacacc aaaacgtccc   1800

ctccacattt ggtgaaatag gaagctccat ggcatgtctc catctttcaa ggtgactgag   1860

aggtttattt tcataggagc ctcagtggcc ttgtccgtac ccacctctgc acgtggttgc   1920

agaaagtgaa ggattgtcag ggagcagggc agacatttgg tttatctgtg tcattggtca   1980

aagttttgtt tttcctccag aagaaaaagg cttgtgaaca tgccaccgta ttcttcattc   2040

cttcttttgg aaatgtatga agaacgggtg gcattttgga gttattggcc tgtgaacagc   2100

tggcccagag gaagggttag atgtgggtgg gtgtggccgc ctctgcccct ccccagcgca   2160

ggtgtgcgtg ggcagcccag gcaggcgctc aggaagggtg aggtggagcc ctgcacgctc   2220

tgagcacaaa gtcctgggat cccttaaacc caagcactgc cttgacagca gccagcatgg   2280

ctgatagaag agacacagaa gtccagctga tgccagacag agggcgtcac tagagagccg   2340

tgctaggtgg gggtcattca agttgtcttg gcgtatgcag acgttgcttc tagagagtca   2400

gaagctctat atgcgtagtg ttggagcaga atttcgggat agtgatggca agcctcctcc   2460

caagccagct ggggagtatg gggagggggt ggccggagga acctggcatc cccgggttag   2520

gaccacagag gtggctctgc ctgcagctgg gcctctgcct catcctgact ccccctgctt   2580

tggccatggc tcttcttgtc cttcctcttc tcagtgcagg aggaccctga atcaaatgcc   2640

tcatcctggt ttgcatttta ccctcggatg aagcttgtgg cgaacccctg gactctgtgt   2700

ctcctgagtc tctgcagacc tcgggtcctg gacccagaga ctcttctccc tgggacagga   2760

ggcactgggg tgggtggaca ggggtggcct ggggcacagt agctgacggg gggacttcct   2820

agttttctgg gcctttccaa ctctgagtgt gaccttccta ttcttgatca cagcccccaa   2880

cttcggagcc tgctagagcc tgcagaatgt ggcttcatcc tcttcctctg tgggaaaagg   2940

cggggcctgg cagtcccgcc aatcttgtat atttgctccc cacctcggtg gtgaatacat   3000

tcttgggtgg tgaataggtt ctctccttgc cttcactcta gaaaagtccc ctgttttgtg   3060

atgtaggatg tggtcaatga ctgactcgtc cctttggacc atagacgcag ctctgatttc   3120

tggtgttcct gggctctgca cacagcagga gccactctgg gctctgagag gtgcatcttc   3180

tggctcactt tcttcttgtt ggctcttctc cctgcgtctt ctgccactgc cctgttctgg   3240

gtgggaggct gtcacactgt ggtggagggt cccctctcct gcctcccctc tttgatcctt   3300

ttctgtgagg gtctgctggg gtcctgtgtg tcgtgcattg ttgatagatt cctgtcgtgc   3360

ttgctgtcct ccccattcta agggacctct gattgcctgt gagcagttta cagggtcctc   3420

tcctggcccc ttcacccgag gaattcccgc aacgcatgag tttgtgaggg gcggatcctg   3480

ggaggatgtg acgtcaggtg agaagggagg gcccgtccta gtccggtggg ctcctctaac   3540

aaagtgcatt agcctgggga gttactgacg ctcgaaatat gtcgtcaaag ttctgaaggc   3600

tgagaagtcc gagatcaaga tgcctgagga ttcagtgcct ggtgaggacc cattccttag   3660

ggcagtgcct ctagctgtgt cctcatgtgg ccgaagggga caagggaggt tgctggagcc   3720

tgtttgatga gagcactacc ttccttcagg aggggattat tcagaaagtc tgtctggttt   3780

cagggcattc ccaaaggccc cacctgttca ttctacccca ttggtagaat tcccattggg   3840

aattaggctt caacatacaa atttgggaga cactgacatt taggccatag cgcgtcaaag   3900

gcaaagtgag gctgagtgtg gaaaccatcc cagaatctgg atgtggccca ggcagaagga   3960

aactcaaagt gatggggtga ccgatggtcc ctggtctgtg caggactcag cggtgcggat   4020

ggccctgggc acggtggcag tggctgttgg aggatgatag ggaacatgtt ggtgggggga   4080

gggtggagcc cactatgagt ggcaactccc tgggggcaca ggaaacaaag ctagaggtgg   4140

ctcccctctc ccctccctgc acacagtgtc acctctgtgg tggccctgtc gtccgcctca   4200

gttcacaggt gttgctgtaa caactcctga aattaccttc aaaaggaggc tcgtgcaggt   4260

gcctgcagga gccaggaggc cgaagtgcat cctgagtgtc cggggacagg ccagcctggc   4320

ggggtccacg gccccacagt cccaacgact gcctcagaaa tgggcagaga gcatgcctgg   4380

ttctagctgg caaggcccac atctcagagc tgtggacagt catgaagggt ccgtgagcat   4440

ggagaggggg caaaaatgac ccatgaacct caggccactg tgctgccatc cagccaagtg   4500

cggtaccagc ccttcgggcc tcgagatcct ctacccttct ctgggccttg ctgatttcct   4560

cctccagccc ctctgtttgt gtacgcacat acacacatgc acgcacgcac acgcacaccc   4620

agtgcaattt ctctctgctc cctgtactcc ccaaaattca atgggttcct ctttcctcct   4680

cagagatata gtcctgggcc ccatctcagc ctgcagaggc ctgaacgttt cccaggattg   4740

tcttctaatt ctcaggtccg gctttaaaac aaaacctaaa ctaaaactaa aatgctttct   4800

gcaaagaata atacaccaac ataaagtccg ggtatcctaa gcatgtggtg tgtatggtgt   4860

ctgaaattga atatgctgtg aaactgcctg tgtcgaaatg cagtgtttcc caagacctgg   4920

aggctctctc cagctgctga ttgtgatcac ctctcccgat caccgctgag ccctgcaggt   4980

caccttctcc tgacctatta caccactgat tgcttatgct gggcacaatt ttataccctt   5040

gctgttgttc agtctaatca tccctataac cctatcggat cattcccata tgacagagga   5100

gaaaacctgg ggacacaggg gctgtgtcct ggccaaggcc ttgcttgcag caaaaggcag   5160

agctggggtc tagccaggag ccccagcaca gtcctgttct tcccccacta aactgagctg   5220

tgaaatagat catggcggtc tggaaaacga gctaattccg tgccgatgga ggtgttgatg   5280

gatgtccacc actctccact tgggaggagg ccttaacatc cccctcaggt ctagcttctc   5340

tctgtgactg agtaccttgg gaaagtgggc tcagaggagg aaagggactt acttgcccaa   5400

gggccacagc tgccaagtgg caggtaaggg accgttattc tcctgtccct ttcacagagg   5460

acaggaggaa agtgaggaca ggtggggtac atgagtttag cctcttttct gcagcaggcc   5520

cagatcagct ttgcacacgg ttggtgctga cctcaaatgc agccctagag gggcctatct   5580

ctgccctgag tattgaggtg caggcttctt cccctttgtt ctgtccattt ccaaaaatgt   5640

gaacacacac ctcctacatg tttatattat tgtgtgcata gatactacca ttgtaacatt   5700

ttttgcggat taaaaatgca ctattgtatt gaaaatttca aaggaaatgt gtaataaaac   5760

atttaaaa                                                            5768


<210>  2455
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  2455

Met Ser Ala Ile Pro Gly Glu Pro Ala Arg Gly Arg Ala Thr Thr Ala 
1               5                   10                  15      


Arg Pro Arg Ala Gln Arg Phe Pro Arg Arg Phe Pro Thr Ala Ser Arg 
            20                  25                  30          


Gly Arg Ala Pro Gly Ala Glu Pro Asn Arg Arg Leu Gln Arg Asp Trp 
        35                  40                  45              


Thr Arg Pro Gly Gly Thr Gly Pro Arg Phe Glu Ser Lys Pro Ser Gly 
    50                  55                  60                  


Val Cys Gly Gly Ser Gly Ala Trp Lys Arg Gly Gly Gly Ala Glu Asn 
65                  70                  75                  80  


Glu Thr Gly Lys Trp Pro Ser Leu Glu Lys Pro Gln Ser Ser Gly Ser 
                85                  90                  95      


Arg Ser Pro Ile Ser Gly Ser Ala Val Cys Leu Gly Ala Val Trp Asn 
            100                 105                 110         


Ile Pro Gln Arg Ser Leu Leu Cys Pro Ala Leu Ala Leu Thr Thr 
        115                 120                 125         


<210>  2456
<211>  1698
<212>  DNA
<213>  Homosapiens

<400>  2456
tcggcacagg agcgaggaga cccgagagca gacgcgccct ggcgcccgcc ctgcgcagtc     60

accatggcga tgcatttcat cttctcagat acagcggtgc ttctgtttga tttctggagt    120

gtccacagtc ctgctggcat ggccctttcg gtgttggtgc tcctgcttct ggctgtactg    180

tatgaaggca tcaaggttgg caaagccaag ctgctcaacc aggtactggt gaacctgcca    240

acctccatca gccagcagac catcgcagag acagacgggg actctgcagg ctcagattca    300

ttccctgttg gcagaaccca ccacaggtgg tacttgtgtc actttggcca gtctctaatc    360

catgtcatcc aggtggtcat cggctacttc atcatgctgg ccgtaatgtc ctacaacacc    420

tggattttcc ttggtgtggt cttgggctct gctgtgggct actacctagc ttacccactt    480

ctcagcacag cttagatggt gaggaacgtg caggcactga ggctggaggg acatggagcc    540

ccctcttcca gacactatac ttccaactgc cctttcttct gatggctatt cctccacctt    600

attcccagcc cctggaaact ttgagctgaa gccagcactt gctccctgga gttcggaagc    660

cattgcagca accttccttc tcagccagcc tacgtagggc ccaggcatgg tcttgtgtct    720

taagacagct gctgtgacca aagggagaat ggagataaca ggggtggcag ggttactgag    780

cccatgacaa tgcttctctg tgactcaaac caggaatttc caaagatttc aagccaggga    840

gaagggttct tggtgatgca gggcatggaa cctggacacc ctcagctctc ctgctttgtg    900

ccttatctac aggagcatcg cccattggac ttcctgacct cttctgtctt tgagggacag    960

agaccaagct agatcctttt tctcaccttt ctgcctttgg aacacatgaa gatcatctcg   1020

tctatggatc atgttgacaa actaagtttt ttttattttt cccattgaac tcctagttgg   1080

caattttgca cattcataca aaaaaatttt taatgaaatg atttcattga ttcatgatgg   1140

atggcagaaa ctgctgagac ctatttccct ttcttgggga gagaataagt gacagctgat   1200

taaaggcaga gacacaggac tgctttcagg ctcctggttt attctctgat tgactgagct   1260

ccttccacca gaaggcactg cctgcaggaa gaagatgatc tgatggccgt gggtgtctgg   1320

gaagctcttc gtggcctcaa tgccctcctt tatcctcatc tttcttctat gcagaacaaa   1380

aagctgcatc taataatgtt caatacttaa tattctctat ttattactta ctgcttactc   1440

gtaatgatct agtggggaaa catgattcat tcacttaaaa tactgattaa gccatgggca   1500

ggtactgact gaagatgcaa tccaaccaaa gccattacat tttttgagtt agatgggact   1560

ctctggatag ttgaacctct tcactttata aaaaaggaaa gagagaaaat cactgctgta   1620

tactaaatac ctcacagatt agatgaaaag atggttgtaa gctttgggaa ttaaaaacaa   1680

atacatttta gtaaatat                                                 1698


<210>  2457
<211>  143
<212>  PRT
<213>  Homosapiens

<400>  2457

Met Ala Met His Phe Ile Phe Ser Asp Thr Ala Val Leu Leu Phe Asp 
1               5                   10                  15      


Phe Trp Ser Val His Ser Pro Ala Gly Met Ala Leu Ser Val Leu Val 
            20                  25                  30          


Leu Leu Leu Leu Ala Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala 
        35                  40                  45              


Lys Leu Leu Asn Gln Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln 
    50                  55                  60                  


Gln Thr Ile Ala Glu Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe 
65                  70                  75                  80  


Pro Val Gly Arg Thr His His Arg Trp Tyr Leu Cys His Phe Gly Gln 
                85                  90                  95      


Ser Leu Ile His Val Ile Gln Val Val Ile Gly Tyr Phe Ile Met Leu 
            100                 105                 110         


Ala Val Met Ser Tyr Asn Thr Trp Ile Phe Leu Gly Val Val Leu Gly 
        115                 120                 125             


Ser Ala Val Gly Tyr Tyr Leu Ala Tyr Pro Leu Leu Ser Thr Ala 
    130                 135                 140             


<210>  2458
<211>  4572
<212>  DNA
<213>  Homosapiens

<400>  2458
atggccggtt gcatacacgg ggaaactgag gcaccgagca ccccggccca aggtcactct     60

ggctatgcca ctgcaggggc cgggccgaag ccccagtctt taaccctcca gtcccgagct    120

ctttctcctt ccgcggagct gaggaaagcg gcgaggaagg tccttgtccc gctgggaaaa    180

ggacggtacc catgcacagg gagcccagtc tactttcggt ccagagaccg tgctggagtt    240

cgccctgccg gaaagcagca cgccgccgcg gcattttacg acgtcggcgg tgacaggccc    300

tgggactctg ggaataccca gcttcctccc cgcaacccgg tgaaagccaa cgcaatgttc    360

ggtgcggggg acgaggacga caccgatttc ctctcgccga gcggcggtgc cagattggcc    420

tcactttttg gactggatca ggcagctgct ggccatggaa atgaattttt ccagtacaca    480

gccccaaaac agcctaagaa aggccaggga acggcagcaa caggaaatca ggcaacacca    540

aaaacagcac cagccaccat gagcactccc acaatactgg tcgcaacagc agtccatgca    600

tatcgataca caaatggtca atatgtaaag cagggcaaat ttggtgctgc agttctgggg    660

aaccacacag ccagagagta taggattctt ctttatatca gtcaacaaca gccagttacg    720

gttgctagga ttcatgtgaa ctttgagcta atggttcggc ccaataacta tagcaccttt    780

tatgatgacc agagacagaa ctggtccatc atgtttgagt cggaaaaggc tgctgtggag    840

ttcaataagc aggtgtgcat tgctaagtgc aacagtacct cttccctgga tgcagtgctc    900

tcccaggacc tcattgtggc agacggccct gctgtagaag ttggagattc tttggaagtg    960

gcctataccg gctggctctt tcagaatcat gtgctgggcc aggttttcga ctccactgct   1020

aacaaagata agttgcttcg cttgaagtta ggatcaggaa aagtcatcaa gggctgggag   1080

gatggaatgc tgggcatgaa aaaaggagga aagcgattgc ttattgtccc tccagcctgt   1140

gctgttggct cagaaggggt aataggctgg actcaagcaa cggactcgat cctggtgttc   1200

gaggtggagg ttaggcgggt gaagtttgcc agagattctg gctctgatgg tcacagtgtt   1260

agttcccgcg attctgcagc tccgtctccc atccctggtg ctgacaacct ctctgctgat   1320

cctgttgtgt caccacccac atcaatacct ttcaaatcag gggagccagc tcttcgtacc   1380

aaatctaact ccctcagtga acaacttgca ataaatacaa gtcccgatgc agtcaaagcc   1440

aagttgatct ctcggatggc taaaatgggc cagcccatgc tgcccatcct tccaccacag   1500

ctggattcca atgattcaga aatcgaagat gtgaacactc tgcaaggagg tgggcagcct   1560

gtggtgactc cgtccgtcca gccctctctt catccggccc atccagcgtt accacagatg   1620

acctcacagg cacctcagcc atctgttact gggctccagg caccttctgc tgccttaatg   1680

caagtgtcat ctctcgattc ccactcagct gtatctggaa atgcccaatc ctttcagccc   1740

tatgcaggta tgcaagccta cgcttatccc caggcatctg ccgtcacctc ccagctgcag   1800

cccgttcggc ctttgtaccc agcaccgctc tctcagcctc cccatttcca aggatcaggt   1860

gatatggctt catttctcat gactgaagcc cggcaacata acactgaaat tcgaatggca   1920

gtcagcaaag tggctgataa aatggatcat ctcatgacta aggttgaaga gttacagaaa   1980

catagtgctg gcaattccat gcttattcct agcatgtcag ttacaatgga aacaagcatg   2040

attatgagca acatccagcg aatcattcag gaaaatgaaa gattgaagca agagatcctt   2100

gaaaagagca atcggataga agaacagaat gacaagatta gtgaactaat tgaacgaaat   2160

cagaggtatg ttgagcagag taacctgatg atggagaaga ggaacaactc acttcagaca   2220

gccacagaaa acacacaggc aagagtattg catgctgaac aagagaaggc caaggtgaca   2280

gaggagttag cagcggccac tgcacaggtc tctcatctgc agctgaaaat gactgctcac   2340

caaaaaaagg aaacagagct gcagatgcag ctgacagaaa gcctgaagga gacagatctt   2400

ctcaggggcc agctcaccaa agtgcaggca aagctctcag agctccaaga aacctctgag   2460

caagcacagt ccaaattcaa aagtgaaaag cagaaccgga aacaactgga actcaaggtg   2520

acatccctgg aggaggaact gactgacctt cgagttgaga aggagtcctt ggaaaagaac   2580

ctctcagaaa ggaaaaagaa gtcagctcaa gagcgttctc aggccgagga ggagatagat   2640

gaaattcgca agtcatacca ggaggaattg gacaaacttc gacagctctt gaaaaagact   2700

cgagtgtcca cagaccaagc agctgcagag cagctgtctt tagtacaggc tgagctacag   2760

acccagtggg aagcaaaatg tgaacatttg ttggcctccg ccaaggatga gcacctgcag   2820

cagtaccagg aggtgtgcgc acagagagat gcctaccagc agaagctggt acaacttcag   2880

gaaaagtgtt tagccctcca ggcccaaatc acagctctca ccaagcaaaa tgaacagcac   2940

atcaaggaac tagagaagaa caagtcccag atgtctgggg ttgaagctgc tgcatctgac   3000

ccctcagaga aggtcaagaa gatcatgaac caggtgttcc agtccttacg gagagagttt   3060

gagctggagg aatcttacaa tggcaggacc attctgggaa ccatcatgaa tacgatcaag   3120

atggtgactc ttcagctgtt aaaccaacag gagcaagaga aggaagagag cagcagtgaa   3180

gaagaagaag aaaaagcaga agagcggcca cgaagacctt cccaggagca gtcagcctca   3240

gccagttctg ggcagcctca agcacccctg aatagggaga ggccagagtc ccccatggtg   3300

ccctcagagc aggtggtcga ggaagctgtc ccgttgcctc ctcaggccct caccacttcc   3360

caggatggac acagaaggaa aggggactca gaagctgagg cactctcaga gataaaagat   3420

ggttcccttc cacccgaact gtcttgcatc ccatcccaca gagttctagg gcccccgact   3480

tcaattccac ctgagcccct aggccctgta tccatggact ctgagtgtga ggagtcactt   3540

gctgccagcc caatggcagc taagcccgac aacccatcag gaaaggtctg tgtcagggaa   3600

gtagcaccag atggcccact acaagaaagc tccacaagac tgtccctgac ttcagacccc   3660

gaggaggggg acccactggc cttagggcct gaaagcccag gagagcctca gcctccacag   3720

ctcaagaaag atgatgtcac tagctccacc ggtccccaca aggagctgtc aagcacagag   3780

gcaggttcca cagttgcagg agcagccctc agacccagcc atcattccca gcgttccagt   3840

ctctctgggg atgaagagga tgaactgttt aaaggggcaa ctctgaaagc tctgaggccc   3900

aaagcacagc ctgaggagga ggatgaagac gaggtgagca tgaagggacg cccgccccca   3960

acgccccttt ttggagatga tgatgatgac gatgacattg actggctggg atgaagaccc   4020

aggaaactgg tgcaaaggtt tctctgcaac ccttccctaa gcatgatttt gcacagccaa   4080

ccctgggtct aggcgaacca cagggtgagg tcaaggtgag cattctggga acaatatttg   4140

ggctcagagg gtgggttggc caccttctga gccccacccc cgccagacct ggtgaagagg   4200

atcataaccc tgtcttcaag aacactggga tttcagcagc aagttggaag aaggactggt   4260

aggttcccct ccaagccagt cacctgtaag agtcctgtcc tctgccagac tttttaatct   4320

cttcattaac tctcagactg acctgggagc cctcctctac ctgaatccag tgctcaactg   4380

tgccccggca acaagacctg ggctgaggtc tccctggtag aactaaggga gattacacca   4440

tctaaatccc agtgcagtca acagcctggc ctatagtcct gggacatgta tcttcttctt   4500

tgccttaaat ctgatacaag aggtcaatga ctttgaaaat aaaactaaaa taaatgtcta   4560

taatgaaact tg                                                       4572


<210>  2459
<211>  1337
<212>  PRT
<213>  Homosapiens

<400>  2459

Met Ala Gly Cys Ile His Gly Glu Thr Glu Ala Pro Ser Thr Pro Ala 
1               5                   10                  15      


Gln Gly His Ser Gly Tyr Ala Thr Ala Gly Ala Gly Pro Lys Pro Gln 
            20                  25                  30          


Ser Leu Thr Leu Gln Ser Arg Ala Leu Ser Pro Ser Ala Glu Leu Arg 
        35                  40                  45              


Lys Ala Ala Arg Lys Val Leu Val Pro Leu Gly Lys Gly Arg Tyr Pro 
    50                  55                  60                  


Cys Thr Gly Ser Pro Val Tyr Phe Arg Ser Arg Asp Arg Ala Gly Val 
65                  70                  75                  80  


Arg Pro Ala Gly Lys Gln His Ala Ala Ala Ala Phe Tyr Asp Val Gly 
                85                  90                  95      


Gly Asp Arg Pro Trp Asp Ser Gly Asn Thr Gln Leu Pro Pro Arg Asn 
            100                 105                 110         


Pro Val Lys Ala Asn Ala Met Phe Gly Ala Gly Asp Glu Asp Asp Thr 
        115                 120                 125             


Asp Phe Leu Ser Pro Ser Gly Gly Ala Arg Leu Ala Ser Leu Phe Gly 
    130                 135                 140                 


Leu Asp Gln Ala Ala Ala Gly His Gly Asn Glu Phe Phe Gln Tyr Thr 
145                 150                 155                 160 


Ala Pro Lys Gln Pro Lys Lys Gly Gln Gly Thr Ala Ala Thr Gly Asn 
                165                 170                 175     


Gln Ala Thr Pro Lys Thr Ala Pro Ala Thr Met Ser Thr Pro Thr Ile 
            180                 185                 190         


Leu Val Ala Thr Ala Val His Ala Tyr Arg Tyr Thr Asn Gly Gln Tyr 
        195                 200                 205             


Val Lys Gln Gly Lys Phe Gly Ala Ala Val Leu Gly Asn His Thr Ala 
    210                 215                 220                 


Arg Glu Tyr Arg Ile Leu Leu Tyr Ile Ser Gln Gln Gln Pro Val Thr 
225                 230                 235                 240 


Val Ala Arg Ile His Val Asn Phe Glu Leu Met Val Arg Pro Asn Asn 
                245                 250                 255     


Tyr Ser Thr Phe Tyr Asp Asp Gln Arg Gln Asn Trp Ser Ile Met Phe 
            260                 265                 270         


Glu Ser Glu Lys Ala Ala Val Glu Phe Asn Lys Gln Val Cys Ile Ala 
        275                 280                 285             


Lys Cys Asn Ser Thr Ser Ser Leu Asp Ala Val Leu Ser Gln Asp Leu 
    290                 295                 300                 


Ile Val Ala Asp Gly Pro Ala Val Glu Val Gly Asp Ser Leu Glu Val 
305                 310                 315                 320 


Ala Tyr Thr Gly Trp Leu Phe Gln Asn His Val Leu Gly Gln Val Phe 
                325                 330                 335     


Asp Ser Thr Ala Asn Lys Asp Lys Leu Leu Arg Leu Lys Leu Gly Ser 
            340                 345                 350         


Gly Lys Val Ile Lys Gly Trp Glu Asp Gly Met Leu Gly Met Lys Lys 
        355                 360                 365             


Gly Gly Lys Arg Leu Leu Ile Val Pro Pro Ala Cys Ala Val Gly Ser 
    370                 375                 380                 


Glu Gly Val Ile Gly Trp Thr Gln Ala Thr Asp Ser Ile Leu Val Phe 
385                 390                 395                 400 


Glu Val Glu Val Arg Arg Val Lys Phe Ala Arg Asp Ser Gly Ser Asp 
                405                 410                 415     


Gly His Ser Val Ser Ser Arg Asp Ser Ala Ala Pro Ser Pro Ile Pro 
            420                 425                 430         


Gly Ala Asp Asn Leu Ser Ala Asp Pro Val Val Ser Pro Pro Thr Ser 
        435                 440                 445             


Ile Pro Phe Lys Ser Gly Glu Pro Ala Leu Arg Thr Lys Ser Asn Ser 
    450                 455                 460                 


Leu Ser Glu Gln Leu Ala Ile Asn Thr Ser Pro Asp Ala Val Lys Ala 
465                 470                 475                 480 


Lys Leu Ile Ser Arg Met Ala Lys Met Gly Gln Pro Met Leu Pro Ile 
                485                 490                 495     


Leu Pro Pro Gln Leu Asp Ser Asn Asp Ser Glu Ile Glu Asp Val Asn 
            500                 505                 510         


Thr Leu Gln Gly Gly Gly Gln Pro Val Val Thr Pro Ser Val Gln Pro 
        515                 520                 525             


Ser Leu His Pro Ala His Pro Ala Leu Pro Gln Met Thr Ser Gln Ala 
    530                 535                 540                 


Pro Gln Pro Ser Val Thr Gly Leu Gln Ala Pro Ser Ala Ala Leu Met 
545                 550                 555                 560 


Gln Val Ser Ser Leu Asp Ser His Ser Ala Val Ser Gly Asn Ala Gln 
                565                 570                 575     


Ser Phe Gln Pro Tyr Ala Gly Met Gln Ala Tyr Ala Tyr Pro Gln Ala 
            580                 585                 590         


Ser Ala Val Thr Ser Gln Leu Gln Pro Val Arg Pro Leu Tyr Pro Ala 
        595                 600                 605             


Pro Leu Ser Gln Pro Pro His Phe Gln Gly Ser Gly Asp Met Ala Ser 
    610                 615                 620                 


Phe Leu Met Thr Glu Ala Arg Gln His Asn Thr Glu Ile Arg Met Ala 
625                 630                 635                 640 


Val Ser Lys Val Ala Asp Lys Met Asp His Leu Met Thr Lys Val Glu 
                645                 650                 655     


Glu Leu Gln Lys His Ser Ala Gly Asn Ser Met Leu Ile Pro Ser Met 
            660                 665                 670         


Ser Val Thr Met Glu Thr Ser Met Ile Met Ser Asn Ile Gln Arg Ile 
        675                 680                 685             


Ile Gln Glu Asn Glu Arg Leu Lys Gln Glu Ile Leu Glu Lys Ser Asn 
    690                 695                 700                 


Arg Ile Glu Glu Gln Asn Asp Lys Ile Ser Glu Leu Ile Glu Arg Asn 
705                 710                 715                 720 


Gln Arg Tyr Val Glu Gln Ser Asn Leu Met Met Glu Lys Arg Asn Asn 
                725                 730                 735     


Ser Leu Gln Thr Ala Thr Glu Asn Thr Gln Ala Arg Val Leu His Ala 
            740                 745                 750         


Glu Gln Glu Lys Ala Lys Val Thr Glu Glu Leu Ala Ala Ala Thr Ala 
        755                 760                 765             


Gln Val Ser His Leu Gln Leu Lys Met Thr Ala His Gln Lys Lys Glu 
    770                 775                 780                 


Thr Glu Leu Gln Met Gln Leu Thr Glu Ser Leu Lys Glu Thr Asp Leu 
785                 790                 795                 800 


Leu Arg Gly Gln Leu Thr Lys Val Gln Ala Lys Leu Ser Glu Leu Gln 
                805                 810                 815     


Glu Thr Ser Glu Gln Ala Gln Ser Lys Phe Lys Ser Glu Lys Gln Asn 
            820                 825                 830         


Arg Lys Gln Leu Glu Leu Lys Val Thr Ser Leu Glu Glu Glu Leu Thr 
        835                 840                 845             


Asp Leu Arg Val Glu Lys Glu Ser Leu Glu Lys Asn Leu Ser Glu Arg 
    850                 855                 860                 


Lys Lys Lys Ser Ala Gln Glu Arg Ser Gln Ala Glu Glu Glu Ile Asp 
865                 870                 875                 880 


Glu Ile Arg Lys Ser Tyr Gln Glu Glu Leu Asp Lys Leu Arg Gln Leu 
                885                 890                 895     


Leu Lys Lys Thr Arg Val Ser Thr Asp Gln Ala Ala Ala Glu Gln Leu 
            900                 905                 910         


Ser Leu Val Gln Ala Glu Leu Gln Thr Gln Trp Glu Ala Lys Cys Glu 
        915                 920                 925             


His Leu Leu Ala Ser Ala Lys Asp Glu His Leu Gln Gln Tyr Gln Glu 
    930                 935                 940                 


Val Cys Ala Gln Arg Asp Ala Tyr Gln Gln Lys Leu Val Gln Leu Gln 
945                 950                 955                 960 


Glu Lys Cys Leu Ala Leu Gln Ala Gln Ile Thr Ala Leu Thr Lys Gln 
                965                 970                 975     


Asn Glu Gln His Ile Lys Glu Leu Glu Lys Asn Lys Ser Gln Met Ser 
            980                 985                 990         


Gly Val Glu Ala Ala Ala Ser Asp  Pro Ser Glu Lys Val  Lys Lys Ile 
        995                 1000                 1005             


Met Asn  Gln Val Phe Gln Ser  Leu Arg Arg Glu Phe  Glu Leu Glu 
    1010                 1015                 1020             


Glu Ser  Tyr Asn Gly Arg Thr  Ile Leu Gly Thr Ile  Met Asn Thr 
    1025                 1030                 1035             


Ile Lys  Met Val Thr Leu Gln  Leu Leu Asn Gln Gln  Glu Gln Glu 
    1040                 1045                 1050             


Lys Glu  Glu Ser Ser Ser Glu  Glu Glu Glu Glu Lys  Ala Glu Glu 
    1055                 1060                 1065             


Arg Pro  Arg Arg Pro Ser Gln  Glu Gln Ser Ala Ser  Ala Ser Ser 
    1070                 1075                 1080             


Gly Gln  Pro Gln Ala Pro Leu  Asn Arg Glu Arg Pro  Glu Ser Pro 
    1085                 1090                 1095             


Met Val  Pro Ser Glu Gln Val  Val Glu Glu Ala Val  Pro Leu Pro 
    1100                 1105                 1110             


Pro Gln  Ala Leu Thr Thr Ser  Gln Asp Gly His Arg  Arg Lys Gly 
    1115                 1120                 1125             


Asp Ser  Glu Ala Glu Ala Leu  Ser Glu Ile Lys Asp  Gly Ser Leu 
    1130                 1135                 1140             


Pro Pro  Glu Leu Ser Cys Ile  Pro Ser His Arg Val  Leu Gly Pro 
    1145                 1150                 1155             


Pro Thr  Ser Ile Pro Pro Glu  Pro Leu Gly Pro Val  Ser Met Asp 
    1160                 1165                 1170             


Ser Glu  Cys Glu Glu Ser Leu  Ala Ala Ser Pro Met  Ala Ala Lys 
    1175                 1180                 1185             


Pro Asp  Asn Pro Ser Gly Lys  Val Cys Val Arg Glu  Val Ala Pro 
    1190                 1195                 1200             


Asp Gly  Pro Leu Gln Glu Ser  Ser Thr Arg Leu Ser  Leu Thr Ser 
    1205                 1210                 1215             


Asp Pro  Glu Glu Gly Asp Pro  Leu Ala Leu Gly Pro  Glu Ser Pro 
    1220                 1225                 1230             


Gly Glu  Pro Gln Pro Pro Gln  Leu Lys Lys Asp Asp  Val Thr Ser 
    1235                 1240                 1245             


Ser Thr  Gly Pro His Lys Glu  Leu Ser Ser Thr Glu  Ala Gly Ser 
    1250                 1255                 1260             


Thr Val  Ala Gly Ala Ala Leu  Arg Pro Ser His His  Ser Gln Arg 
    1265                 1270                 1275             


Ser Ser  Leu Ser Gly Asp Glu  Glu Asp Glu Leu Phe  Lys Gly Ala 
    1280                 1285                 1290             


Thr Leu  Lys Ala Leu Arg Pro  Lys Ala Gln Pro Glu  Glu Glu Asp 
    1295                 1300                 1305             


Glu Asp  Glu Val Ser Met Lys  Gly Arg Pro Pro Pro  Thr Pro Leu 
    1310                 1315                 1320             


Phe Gly  Asp Asp Asp Asp Asp  Asp Asp Ile Asp Trp  Leu Gly 
    1325                 1330                 1335         


<210>  2460
<211>  4735
<212>  DNA
<213>  Homosapiens

<400>  2460
agaagtggag gggccgttcg aagagtcgtg agggggtgac gggttaagat tcggagagag     60

aggtgctagt ggctggactt gacctggaag gaatcttctg ctgactctca acttttcctg    120

gaaaaaatgg atcattccca ccatatgggg atgagctata tggactccaa cagtaccatg    180

caaccttctc accatcaccc aaccacttca gcctcacact cccatggtgg aggagacagc    240

agcatgatga tgatgcctat gaccttctac tttggcttta agaatgtgga actactgttt    300

tccggtttgg tgatcaatac agctggagaa atggctggag cttttgtggc agtgttttta    360

ctagcaatgt tctatgaagg actcaagata gcccgagaga gcctgctgcg taagtcacaa    420

gtcagcattc gctacaattc catgcctgtc ccaggaccaa atggaaccat ccttatggag    480

acacacaaaa ctgttgggca acagatgctg agctttcctc acctcctgca aacagtgctg    540

cacatcatcc aggtggtcat aagctacttc ctcatgctca tcttcatgac ctacaacggg    600

tacctctgca ttgcagtagc agcaggggcc ggtacaggat acttcctctt cagctggaag    660

aaggcagtgg tagtggatat cacagagcat tgccattgac atcaaactct atggcgtggc    720

cttatcgatt gcagtgggaa gttgttgaag acttgaagac gtgattcctg ctccaatcat    780

cccttcttgc tcctctttgt gcacgtacac acacacacac acacacacac acacacaccc    840

ctgctcaaca gaggtttagt ttacagtctc tgaactaaag tagtaacctc ccaaattgtt    900

ttttctaata agctgagatt cccatttctc ttaaggagaa gccacccatg agatgtcttt    960

tccttctcca tcatcttaga gccaagttat atgttcttgt ctaatccatg tagctttttg   1020

ttcaatgact tgatcatctg cttccttttt gaatttttaa cagatagtaa gtaaatttgg   1080

tggttttttc ccctgggtca gtgatggaaa ggggttaact tcagccagga ttgatggcag   1140

ctgagggaaa ttcttgccca actaaaccca gaactcaaac ttaacattag aaaataaggt   1200

ccagggccgg acacagtggc ccatgcctgt aatcccagca ctttgggggg ccaaggcagg   1260

ctggatcacc tgaggacagg agttcgagac cagtctggcc aacatgggga aaccccgtct   1320

ctactaaaaa tacaaaaatt agccgggcat ggtggtgggc gcctgtaatc ccagctactc   1380

agaaggctga ggcaggagaa tcacttgaac ctaggaggcg gaggttgcag tgagccaaga   1440

tggcgccatt gcactccagc ctgggtgaca agagtgaaac tccatctcaa aaaaaaagaa   1500

aagaaggtcc agcttttgga ttcaatgagt gggaaataca ttgtgccttt ctctagatgt   1560

gatacgttat accaaaatct ttgtagtgtg cagagcggtg gtttgagact aaatacaggc   1620

ttagaacttg cagagtgtgt attcttggat ggctgatgca tcgacttgca ttcccactta   1680

acactctgat tagcatgaac ttgccaatca aaaaatgaca atcaatttga gaaaatagaa   1740

atagatattt ttaaataaaa ccattcacag tttactttgt cttgatacct tggtttgtcc   1800

cagctgaagt gaagcaagag agtttgaatt aatttttcca ttataatgtt ttcgcatgtc   1860

tgcctctaaa actgtgattt tcaagcttta gcgtgcatca gaaccacctg tagggcttgt   1920

taaaacacta attgctgggc ctcaacccaa aagcccccaa agtggcactt ctgagttcct   1980

gctgatgtta caagggacca cacttttgag aatctgtgct ttaagctaag gaaatattgc   2040

ctggtgggtt ggctgcctgg tattgggcat ggaaatttga attgctgatt ggtagatggt   2100

gtgtctggac ctaactcacg tagtaaatac tgctgatcaa tacctaatca ttccacattt   2160

attgagctcc acctgtgtgt atgtgtaccc aagcacacat gtgtgaaggg ctatagccaa   2220

agtattttta ctagcctgta tgaaatcact agtccttatt tttaaaggtc tatggtttct   2280

tggaagtagt ttgattgttg agagagacct ttgatctgca gtgtaaatct accagtcatg   2340

ggccagaagg gcaaaagccc agctttctct ttggaaagac tcaggctgtg gtttgttgat   2400

ggccaggttt tcctcaggct ccaacaactg tgcttatacc aagcagatcc tcatcctcca   2460

tataatcatc tttgttattc gtgggggttt aattacatta caagtggcca aaacccctgt   2520

tctcagtgaa gaaccacatt ggatttgtat tctgttcagt tgtagtctac actgcagtct   2580

tattcctggt tcaaactacc tctttaaatt gatttgtctt gtgctggtct gttaaatcct   2640

gccctccttg gtgctagatc cagttgtgcc tcagggcaga ggaaacaaaa cacagctatc   2700

ctgttggcct gtgttgtggt tttgaagttt gtactttctc tgtgggtgcc agttaaatat   2760

tggagagcaa ggaatgtgga cttgtatggc tttgaaccaa gagagggtta tgagcctact   2820

ggattgaggt taaaatccaa gaaccaacat ttagagcttt gtgcttttct ctcattccat   2880

cactttgtaa tgatgatact taacatgagc agggtgaatg acaggtactg acgaagtcca   2940

acacaaaggt ataatacagc ctgttgtcta aagccaagga gtcataaaac catgagaaat   3000

aaataggaat caatagttag tagtgacatt ggtgctctct agaaatctca gcatgagctg   3060

ctatagaata ccctcccagc aacaaaacct aatcagtaag gccagctaga cccaatggct   3120

catgcctgta atcccaacac tttgggaggc caaggtggga ggatggcttg tgtccagaag   3180

ttcgagacca gcctggacaa catagtgaga tcctatctct ataaaaaatc aaaaattagc   3240

caggcatggt ggtgcatacc tatagtcctg gctatttggg aggctgaggc aggaggattg   3300

ctttagccct ggaggtcgag gctgcagtaa gccatgattg cgccactgca ctcagcccgg   3360

gtgacaaagc aagaccctgt ctcagaaaaa aagaaaattc aaggccagtt aagacagaat   3420

gctatgactt tgaaattcac agaaagaaat aacagtttag attaggtctt caggtattca   3480

ggatagagat aatctcctga aaaacctgaa tttcagagat tcttagactg gctgccaaag   3540

gatgaagcta gtgaaggaga aaaagcttaa attccatctt gagctcttgg attgtgataa   3600

tacaatgatt tcattaactt ttcatttctg tatacctgtt catttggaat ttaatgcttg   3660

acttctttgt tcattttgga tctaaacttc tcttttcttc cttccccatt cacatctatt   3720

agaagactgc accaccattt ctttggcccc cttactctgt tgtcctttcc cttttctttc   3780

agttttttta atcgcatgtc tagtatatta agtctccata gccctcctga tgcagtagac   3840

agtgctatgc tgtggatata ataccaacca gaaattggca tttataaacc tgttaagaga   3900

ctttaagcat gtttcaagag gcagttgccc cactggaatt tctataaggc tggtaccctt   3960

cccagagtta cagaatcttg ggtgctatct ctagtctgtg agggaggaac tcccagcatc   4020

cccattgccc acaaatggga tcctcactgt atccactagg agattagaaa ttaaggtttc   4080

ttcactactt ctatggtagg gttgtctgaa attccctttc aggctgtggg tactggtctt   4140

gggttctagt cataaggggt tccttataag gagcaggcgg aggggagtac actttcatgt   4200

gatttaattt tgatcctgcc ctctccagct gctccttcaa aagaaacatc aaaagataga   4260

aactctgggc tgggcacagt ggctcacaca ctttgggagg ccaagcgggg gtgcagatca   4320

cctgaggtca ggagtttgag accagcctgg ccaatgtggt gaaaccccat ctctactaaa   4380

aatacaaaaa ttagctgggc gtggtggtgc atgcctgtaa tcccagctac tcgggaggct   4440

gaggcaggag aatcgcttga acccaggagg cggaggttgc agtgagccaa gatggcgcca   4500

ttgcactcca gcctgggcga caagagcaaa actccgtctc aaaaaaaaaa aagatacaaa   4560

gtctgcattt gatataatgc cttaattact gggtctacaa ttaatgttga ctgttttaga   4620

ttgtaagctc ctggagagca gtattgctgt agtaggaatg ttttaacagt gtcatatgaa   4680

aaagaacaaa ataaatattt tgattttgtg attctaaaaa aaaaaaaaaa aaaaa        4735


<210>  2461
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  2461

Met Asp His Ser His His Met Gly Met Ser Tyr Met Asp Ser Asn Ser 
1               5                   10                  15      


Thr Met Gln Pro Ser His His His Pro Thr Thr Ser Ala Ser His Ser 
            20                  25                  30          


His Gly Gly Gly Asp Ser Ser Met Met Met Met Pro Met Thr Phe Tyr 
        35                  40                  45              


Phe Gly Phe Lys Asn Val Glu Leu Leu Phe Ser Gly Leu Val Ile Asn 
    50                  55                  60                  


Thr Ala Gly Glu Met Ala Gly Ala Phe Val Ala Val Phe Leu Leu Ala 
65                  70                  75                  80  


Met Phe Tyr Glu Gly Leu Lys Ile Ala Arg Glu Ser Leu Leu Arg Lys 
                85                  90                  95      


Ser Gln Val Ser Ile Arg Tyr Asn Ser Met Pro Val Pro Gly Pro Asn 
            100                 105                 110         


Gly Thr Ile Leu Met Glu Thr His Lys Thr Val Gly Gln Gln Met Leu 
        115                 120                 125             


Ser Phe Pro His Leu Leu Gln Thr Val Leu His Ile Ile Gln Val Val 
    130                 135                 140                 


Ile Ser Tyr Phe Leu Met Leu Ile Phe Met Thr Tyr Asn Gly Tyr Leu 
145                 150                 155                 160 


Cys Ile Ala Val Ala Ala Gly Ala Gly Thr Gly Tyr Phe Leu Phe Ser 
                165                 170                 175     


Trp Lys Lys Ala Val Val Val Asp Ile Thr Glu His Cys His 
            180                 185                 190 


<210>  2462
<211>  885
<212>  DNA
<213>  Homosapiens

<400>  2462
ggagcatgat ggaagtcgta gtaggaaatg gcgtcgtggc attgaggggc atccctccta     60

gaacctccag gaaaagctcg cggaagacga ggttctgcgg agagagaggc tccaagcagt    120

ctgggaagtg tagtccagtt ggcttagcag tagtttcgtt gggggggagc cgaggttccg    180

ggaaggggct aggccggctt gaaaagagat tatgactgta ccttttaact ttgtagctgg    240

aacacaagaa gtgtttgttt aatgaatgac gtacacattt aagatctgtt tggacgcgga    300

ggataatcct gtgaattgct aatagttcac tgggtttggc ccttagtgtt gacttcagta    360

tgctgagacg gaaaccaaca cgcctagagc taaagcttga tgacattgaa gagtttgaga    420

acattcgaaa ggacctggag acccgtaaga aacagaagga agatgtggaa gttgtaggag    480

gcagtgatgg agaaggagcc attgggctta gcagtgatcc caagagccgg gaacaaatga    540

tcaatgatcg gattggttat aaaccccaac ccaagcccaa taatcgttca tctcaatttg    600

gaagtcttga attttagaga tggattatct tgcatgccag agcgctggaa tggaataaaa    660

tgatggcaga agtacaaacc agatttagag aattgagtgc ttgcagtcaa gcagaatgta    720

cctcctgcag agacaaatct tctgcatgag attactgatg cttcacttgc actctaagct    780

ggaatccaaa ctctggtttg tctcttgaaa atttgactct ataaaactga tctgattttc    840

tgtttttaaa aataaatata tttttggaaa aaaaaaaaaa aaaaa                    885


<210>  2463
<211>  85
<212>  PRT
<213>  Homosapiens

<400>  2463

Met Leu Arg Arg Lys Pro Thr Arg Leu Glu Leu Lys Leu Asp Asp Ile 
1               5                   10                  15      


Glu Glu Phe Glu Asn Ile Arg Lys Asp Leu Glu Thr Arg Lys Lys Gln 
            20                  25                  30          


Lys Glu Asp Val Glu Val Val Gly Gly Ser Asp Gly Glu Gly Ala Ile 
        35                  40                  45              


Gly Leu Ser Ser Asp Pro Lys Ser Arg Glu Gln Met Ile Asn Asp Arg 
    50                  55                  60                  


Ile Gly Tyr Lys Pro Gln Pro Lys Pro Asn Asn Arg Ser Ser Gln Phe 
65                  70                  75                  80  


Gly Ser Leu Glu Phe 
                85  


<210>  2464
<211>  2756
<212>  DNA
<213>  Homosapiens

<400>  2464
gaaagggagt gttcgggttt cgctggggcc tcgcggctcc agagcccagc atggcttcct     60

cgcgagcctc ttccacgcag gcaaccaaaa ctaaagcacc cgacgactta gttgctccgg    120

tcgtgaagaa accacacatc tattatggaa gtttggaaga gaaggagagg gagcgtctgg    180

ccaaaggaga gtctgggatt ttggggaaag acggacttaa agcagggatc gaagctggaa    240

atattaatat aacctctgga gaagtgtttg aaattgaaga gcatatcagc gagcgacagg    300

cagaagtatt ggctgagttt gagagaagga agcgagcccg gcagatcaat gtttccacag    360

atgactcaga ggtcaaagct tgccttagag ccttggggga acccatcaca ctttttggag    420

agggtcctgc tgaaagaaga gaaaggttaa gaaatatcct ctcagttgtc ggtactgatg    480

ccttgaaaaa gaccaaaaag gatgatgaga agtctaaaaa gtccaaagaa gagtatcagc    540

aaacctggta tcatgaagga ccaaatagct tgaaggtggc aagactatgg attgctaatt    600

attcgttgcc cagggcaatg aaacgcttgg aagaggcccg actccataag gagattcctg    660

agacaacaag gacctcccag atgcaagagc tgcacaagtc tctccggtct ttgaataatt    720

tttgcagtca gattggggat gatcggccta tctcctactg tcactttagt cccaattcca    780

agatgctggc cacagcttgt tggagtgggc tttgcaagct ctggtctgtt cctgattgca    840

acctccttca cactcttcga gggcataaca caaatgtagg agcaattgta ttccatccca    900

aatccactgt ctccttggac ccaaaagatg tcaacctggc ctcttgtgcg gctgatggct    960

ctgtgaagct ttggagtctc gacagtgatg aaccagtggc agatattgaa ggccatacag   1020

tgcgtgtggc gcgggtaatg tggcatcctt caggacgttt cctgggcacc acctgctatg   1080

accgttcatg gcgcttatgg gatttggagg ctcaagagga gatcctgcat caggaaggcc   1140

atagcatggg tgtgtatgac attgccttcc atcaagatgg ctctttggct ggcactgggg   1200

gactggatgc atttggtcga gtttgggacc tacgcacagg acgttgtatc atgttcttag   1260

aaggccacct gaaagaaatc tatggaataa atttctcccc caatggctat cacattgcaa   1320

ccggcagtgg tgacaacacc tgcaaagtgt gggacctccg acagcggcgt tgcgtctaca   1380

ccatccctgc tcatcagaac ttagtgactg gtgtcaagtt tgagcctatc catgggaact   1440

tcttgcttac tggtgcctat gataacacag ccaagatctg gacgcaccca ggctggtccc   1500

cgctgaagac tctggctggc cacgaaggca aagtgatggg cctagatatt tcttccgatg   1560

ggcagctcat agccacttgc tcatatgaca ggaccttcaa gctgtggatg gctgaataga   1620

tgacaatggg aaaaggactt gaacctcaag ctctctctaa ggagctgttt tcctcaaacg   1680

agaagaattg aagtgtttag ttctatcatg ttttctgcca attaccatgc atagaccctc   1740

agtagaattg gatttccatg tcagccccca ctccaggaag gcagcccaat ccctaggtga   1800

tggggaaccc ctctcacggt tgaaaattta ttaccttttt acgccctgcc acgaactgtg   1860

tagacattgt ttttattaat cttttgtttg gccgggcgtg gtggctcacg cctgtaatcc   1920

tagcactttg ggaggccgag gtgggtagat cgcttgagct caggagttca agacgagcct   1980

gggcaacatg gcaaatgccg tctctgcaaa aaaatactaa aattagctgg tcgcggtggc   2040

ttctgcctgt gattccggct acttgggagg ctgaggtggg agggattgct taagcctggg   2100

aggcagaggt tgcagtgagc cgagattgcg ccattgcact ctagcctgtg tgacagagca   2160

agaccctgtc tcaaaaaaaa aaaaaatttg ttcgaatgcc ttatagcctt cctcacagca   2220

cccaggattg tgactgactc tgcattttta attcttgaaa cttggctttc cataacatgg   2280

tacatgcttc aggactacat atgacccaga gagcaaggtg gctgaactat agtctggaag   2340

ccctcaggta aagaggcaca tctcaccact cattggttaa acaatgcatc atagcgagca   2400

cttttccttt ccctggagaa tgggatgtga agcagtagac cgcagccacg ccgatggtta   2460

tacagtgaag aagacttcac ctcttcctat tgagtttgct tggaatgctg acagcatcag   2520

gcaactctga actgaacatt tgctttgtca gaaaatatct ttttttttac tttgaagttt   2580

ggcaaccttc atgttacccc aaagcaaaac cattgtgtca ggagtcaaac aaatgtttag   2640

aaagcaaaca tgacgtctct attgtacaac ctcctttctc ttggctgttt aaaggatgta   2700

cttcgtgtat taaagggtac tttatgttga agtaaaaaaa aaaaaaaaaa aaaaaa       2756


<210>  2465
<211>  522
<212>  PRT
<213>  Homosapiens

<400>  2465

Met Ala Ser Ser Arg Ala Ser Ser Thr Gln Ala Thr Lys Thr Lys Ala 
1               5                   10                  15      


Pro Asp Asp Leu Val Ala Pro Val Val Lys Lys Pro His Ile Tyr Tyr 
            20                  25                  30          


Gly Ser Leu Glu Glu Lys Glu Arg Glu Arg Leu Ala Lys Gly Glu Ser 
        35                  40                  45              


Gly Ile Leu Gly Lys Asp Gly Leu Lys Ala Gly Ile Glu Ala Gly Asn 
    50                  55                  60                  


Ile Asn Ile Thr Ser Gly Glu Val Phe Glu Ile Glu Glu His Ile Ser 
65                  70                  75                  80  


Glu Arg Gln Ala Glu Val Leu Ala Glu Phe Glu Arg Arg Lys Arg Ala 
                85                  90                  95      


Arg Gln Ile Asn Val Ser Thr Asp Asp Ser Glu Val Lys Ala Cys Leu 
            100                 105                 110         


Arg Ala Leu Gly Glu Pro Ile Thr Leu Phe Gly Glu Gly Pro Ala Glu 
        115                 120                 125             


Arg Arg Glu Arg Leu Arg Asn Ile Leu Ser Val Val Gly Thr Asp Ala 
    130                 135                 140                 


Leu Lys Lys Thr Lys Lys Asp Asp Glu Lys Ser Lys Lys Ser Lys Glu 
145                 150                 155                 160 


Glu Tyr Gln Gln Thr Trp Tyr His Glu Gly Pro Asn Ser Leu Lys Val 
                165                 170                 175     


Ala Arg Leu Trp Ile Ala Asn Tyr Ser Leu Pro Arg Ala Met Lys Arg 
            180                 185                 190         


Leu Glu Glu Ala Arg Leu His Lys Glu Ile Pro Glu Thr Thr Arg Thr 
        195                 200                 205             


Ser Gln Met Gln Glu Leu His Lys Ser Leu Arg Ser Leu Asn Asn Phe 
    210                 215                 220                 


Cys Ser Gln Ile Gly Asp Asp Arg Pro Ile Ser Tyr Cys His Phe Ser 
225                 230                 235                 240 


Pro Asn Ser Lys Met Leu Ala Thr Ala Cys Trp Ser Gly Leu Cys Lys 
                245                 250                 255     


Leu Trp Ser Val Pro Asp Cys Asn Leu Leu His Thr Leu Arg Gly His 
            260                 265                 270         


Asn Thr Asn Val Gly Ala Ile Val Phe His Pro Lys Ser Thr Val Ser 
        275                 280                 285             


Leu Asp Pro Lys Asp Val Asn Leu Ala Ser Cys Ala Ala Asp Gly Ser 
    290                 295                 300                 


Val Lys Leu Trp Ser Leu Asp Ser Asp Glu Pro Val Ala Asp Ile Glu 
305                 310                 315                 320 


Gly His Thr Val Arg Val Ala Arg Val Met Trp His Pro Ser Gly Arg 
                325                 330                 335     


Phe Leu Gly Thr Thr Cys Tyr Asp Arg Ser Trp Arg Leu Trp Asp Leu 
            340                 345                 350         


Glu Ala Gln Glu Glu Ile Leu His Gln Glu Gly His Ser Met Gly Val 
        355                 360                 365             


Tyr Asp Ile Ala Phe His Gln Asp Gly Ser Leu Ala Gly Thr Gly Gly 
    370                 375                 380                 


Leu Asp Ala Phe Gly Arg Val Trp Asp Leu Arg Thr Gly Arg Cys Ile 
385                 390                 395                 400 


Met Phe Leu Glu Gly His Leu Lys Glu Ile Tyr Gly Ile Asn Phe Ser 
                405                 410                 415     


Pro Asn Gly Tyr His Ile Ala Thr Gly Ser Gly Asp Asn Thr Cys Lys 
            420                 425                 430         


Val Trp Asp Leu Arg Gln Arg Arg Cys Val Tyr Thr Ile Pro Ala His 
        435                 440                 445             


Gln Asn Leu Val Thr Gly Val Lys Phe Glu Pro Ile His Gly Asn Phe 
    450                 455                 460                 


Leu Leu Thr Gly Ala Tyr Asp Asn Thr Ala Lys Ile Trp Thr His Pro 
465                 470                 475                 480 


Gly Trp Ser Pro Leu Lys Thr Leu Ala Gly His Glu Gly Lys Val Met 
                485                 490                 495     


Gly Leu Asp Ile Ser Ser Asp Gly Gln Leu Ile Ala Thr Cys Ser Tyr 
            500                 505                 510         


Asp Arg Thr Phe Lys Leu Trp Met Ala Glu 
        515                 520         


<210>  2466
<211>  1265
<212>  DNA
<213>  Homosapiens

<400>  2466
cgattcaggg gagggagcaa ctggagcctc aggccctcca gagtagtctg cctgaccacc     60

ctggagccca cagaagccca ggacgtctcc cgcgaggcct ccccgtgtgt ggctgaggat    120

ggctgagcag cagggccggg agcttgaggc tgagtgcccc gtctgctgga accccttcaa    180

caacacgttc cataccccca aaatgctgga ttgctgccac tccttctgcg tggaatgtct    240

ggcccacctc agccttgtga ctccagcccg gcgccgcctg ctgtgcccac tctgtcgcca    300

gcccacagtg ctggcctcag ggcagcctgt cactgacttg cccacggaca ctgccatgct    360

caccctgctc cgcctggagc cccaccatgt catcctggaa ggccatcagc tgtgcctcaa    420

ggaccagccc aagagccgct acttcctgcg ccagcctcga gtctacacgc tggaccttgg    480

cccccagcct gggggccaga ctgggccgcc cccagacacg gcctctgcca ccgtgtctac    540

gcccatcctc atccccagcc accactcttt gagggagtgt ttccgcaacc ctcagttccg    600

catctttgcc tacctgatgg ccgtcatcct cagtgtcact ctgttgctca tattctccat    660

cttttggacc aagcagttcc tttggggtgt ggggtgagtg ctgttcccag acaagaaacc    720

aaaccttttt cggttgctgc tgggtatggt gactacggag cctcatttgg tattgtcttc    780

ctttgtagtg ttgtttattt tacaatccag ggattgttca ggccatgtgt ttgcttctgg    840

gaacaattta aaaaaaaaac aaaaaaacga aaagcttgaa ggactgggag atgtggagcg    900

acctccgggt gtgagtgtgg cgtcatggaa gggcagagaa gcggttctga ccacagagct    960

ccacagcaag ttgtgccaaa gggctgcaca gtggtatcca ggaacctgac tagcccaaat   1020

agcaagttgc atttctcact ggagctgctt caaaatcagt gcatattttt ttgagttgct   1080

cttttactat gggttgctaa aaaaaaaaaa aaaaaaattg ggaagtgagc ttcaattctg   1140

tgggtaaatg tgtgtttgtt tctctttgaa tgtcttgcca ctggttgcag taaaagtgtt   1200

ctgtattcat taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1260

aaaaa                                                               1265


<210>  2467
<211>  192
<212>  PRT
<213>  Homosapiens

<400>  2467

Met Ala Glu Gln Gln Gly Arg Glu Leu Glu Ala Glu Cys Pro Val Cys 
1               5                   10                  15      


Trp Asn Pro Phe Asn Asn Thr Phe His Thr Pro Lys Met Leu Asp Cys 
            20                  25                  30          


Cys His Ser Phe Cys Val Glu Cys Leu Ala His Leu Ser Leu Val Thr 
        35                  40                  45              


Pro Ala Arg Arg Arg Leu Leu Cys Pro Leu Cys Arg Gln Pro Thr Val 
    50                  55                  60                  


Leu Ala Ser Gly Gln Pro Val Thr Asp Leu Pro Thr Asp Thr Ala Met 
65                  70                  75                  80  


Leu Thr Leu Leu Arg Leu Glu Pro His His Val Ile Leu Glu Gly His 
                85                  90                  95      


Gln Leu Cys Leu Lys Asp Gln Pro Lys Ser Arg Tyr Phe Leu Arg Gln 
            100                 105                 110         


Pro Arg Val Tyr Thr Leu Asp Leu Gly Pro Gln Pro Gly Gly Gln Thr 
        115                 120                 125             


Gly Pro Pro Pro Asp Thr Ala Ser Ala Thr Val Ser Thr Pro Ile Leu 
    130                 135                 140                 


Ile Pro Ser His His Ser Leu Arg Glu Cys Phe Arg Asn Pro Gln Phe 
145                 150                 155                 160 


Arg Ile Phe Ala Tyr Leu Met Ala Val Ile Leu Ser Val Thr Leu Leu 
                165                 170                 175     


Leu Ile Phe Ser Ile Phe Trp Thr Lys Gln Phe Leu Trp Gly Val Gly 
            180                 185                 190         


<210>  2468
<211>  3105
<212>  DNA
<213>  Homosapiens

<400>  2468
gtcccgcagt ggctggagcc ctgggcgctg caaagcgtgt cccgccgggt ccccgagcgt     60

cccgcgccct cgccccgcca tgctcctgct gctggggctg tgcctggggc tgtccctgtg    120

tgtggggtcg caggaagagg cgcagagctg gggccactct tcggagcagg atggactcag    180

ggtcccgagg caagtcagac tgttgcagag gctgaaaacc aaacctttga tgacagaatt    240

ctcagtgaag tctaccatca tttcccgtta tgccttcact acggtttcct gcagaatgct    300

gaacagagct tctgaagacc aggacattga gttccagatg cagattccag ctgcagcttt    360

catcaccaac ttcactatgc ttattggaga caaggtgtat cagggcgaaa ttacagagag    420

agaaaagaag agtggtgata gggtaaaaga gaaaaggaat aaaaccacag aagaaaatgg    480

agagaagggg actgaaatat tcagagcttc tgcagtgatt cccagcaagg acaaagccgc    540

ctttttcctg agttatgagg agcttctgca gaggcgcctg ggcaagtacg agcacagcat    600

cagcgtgcgg ccccagcagc tgtccgggag gctgagcgtg gacgtgaata tcctggagag    660

cgcgggcatc gcatccctgg aggtgctgcc gcttcacaac agcaggcaga ggggcagtgg    720

gcgcggggaa gatgattctg ggcctccccc atctactgtc attaaccaaa atgaaacatt    780

tgccaacata atttttaaac ctactgtagt acaacaagcc aggattgccc agaatggaat    840

tttgggagac tttatcatta gatatgacgt caatagagaa cagagcattg gggacatcca    900

ggttctaaat ggctattttg tgcactactt tgctcctaaa gaccttcctc ctttacccaa    960

gaatgtggta ttcgtgcttg acagcagtgc ttctatggtg ggaaccaaac tccggcagac   1020

caaggatgcc ctcttcacaa ttctccatga cctccgaccc caggaccgtt tcagtatcat   1080

tggattttcc aaccggatca aagtatggaa ggaccacttg atatcagtca ctccagacag   1140

catcagggat gggaaagtgt acattcacca tatgtcaccc actggaggca cagacatcaa   1200

cggggccctg cagagggcca tcaggctcct caacaagtac gtggcccaca gtggcattgg   1260

agaccggagc gtgtccctca tcgtcttcct gacggatggg aagcccacgg tcggggagac   1320

gcacaccctc aagatcctca acaacacccg agaggccgcc cgaggccaag tctgcatctt   1380

caccattggc atcggcaacg acgtggactt caggctgctg gagaaactgt cgctggagaa   1440

ctgtggcctc acacggcgcg tgcacgagga ggaggacgca ggctcgcagc tcatcgggtt   1500

ctacgatgaa atcaggaccc cgctcctctc tgacatccgc atcgattatc cccccagctc   1560

agtggtgcag gccaccaaga ccctgttccc caactacttc aacggctcgg agatcatcat   1620

tgcggggaag ctggtggaca ggaagctgga tcacctgcac gtggaggtca ccgccagcaa   1680

cagtaagaaa ttcatcatcc tgaagacaga tgtgcctgtg cggcctcaga aggcagggaa   1740

agatgtcaca ggaagcccca ggcctggagg cgatggagag ggggacacca accacatcga   1800

gcgtctctgg agctacctca ccacaaagga gctgctgagc tcctggctgc aaagtgacga   1860

tgaaccggag aaggagcggc tgcggcagcg ggcccaggcc ctggctgtga gctaccgctt   1920

cctcactccc ttcacctcca tgaagctgag ggggccggtc ccacgcatgg atggcctgga   1980

ggaggcccac ggcatgtcgg ctgccatggg acccgaaccg gtggtgcaga gcgtgcgagg   2040

agctggcacg cagccaggac ctttgctcaa gaagccatac cagccaagaa ttaaaatctc   2100

taaaacatca gttcgtggct tcagaaggga agaacagatt ttttcaaatg tcatgaaatt   2160

tccttttgcc agcatcctgg aactataata aaaattcaga ggaaagaaca acctatgact   2220

gggttttgtt ctgctgtgtc cagatcatcc tctggaagtc ttgattgttg cctttctgct   2280

gctgtgctgt acgtgcaagt tcctaaagcc agggacatcc cggagatgag ctgtggatat   2340

agagtccgca cagcctgcgg gagacagaat gtaattcctt ccaacacaca cacacaggct   2400

ttatggaatg ccagaaaagc ttcctcttgg atgctgcctg gagtaatgac tttttgaccc   2460

tcccctcttt tttggagcaa gcactatctt tccttgtaaa gaaatttgga caatttgagt   2520

agaaatggtg tggtatgtgc acatagaaac tctcagaaaa ctgtcagatg agctagacag   2580

ttgtcctcta tctccatggg tcccgcatcc caaggatcga accaacaaca gatcaaaaat   2640

acgtgaaaaa ggaattgcat ctgtattgaa tgtgtacgga ctttttttct tgtctttgtt   2700

ccttaaacaa tgtagtgtaa caactattta catcgcatct cctttgcatt cattattata   2760

agtaaactag agatgattta aagtgtatag aaaggctgcg tgcagtggct aatgtctgta   2820

atcccagcac tttgagaggc cgaggcaggt ggatcacctg aggtcaggag ttcgagacca   2880

gcctggccaa cgtggtgaaa ccccatctct actaaaaata caataattag ctgggcatgg   2940

tggtgcacgc ctgtaatccc agctattcgg gaggctgagg caggagaatc gcttgaaccc   3000

aggaggcaga gattgcagtg aaccgagatt gcaccattgc actccagcct gggtgacaga   3060

gtgaacctcc gtctcaaaaa caaaataaat aaataagaat aaatt                   3105


<210>  2469
<211>  702
<212>  PRT
<213>  Homosapiens

<400>  2469

Met Leu Leu Leu Leu Gly Leu Cys Leu Gly Leu Ser Leu Cys Val Gly 
1               5                   10                  15      


Ser Gln Glu Glu Ala Gln Ser Trp Gly His Ser Ser Glu Gln Asp Gly 
            20                  25                  30          


Leu Arg Val Pro Arg Gln Val Arg Leu Leu Gln Arg Leu Lys Thr Lys 
        35                  40                  45              


Pro Leu Met Thr Glu Phe Ser Val Lys Ser Thr Ile Ile Ser Arg Tyr 
    50                  55                  60                  


Ala Phe Thr Thr Val Ser Cys Arg Met Leu Asn Arg Ala Ser Glu Asp 
65                  70                  75                  80  


Gln Asp Ile Glu Phe Gln Met Gln Ile Pro Ala Ala Ala Phe Ile Thr 
                85                  90                  95      


Asn Phe Thr Met Leu Ile Gly Asp Lys Val Tyr Gln Gly Glu Ile Thr 
            100                 105                 110         


Glu Arg Glu Lys Lys Ser Gly Asp Arg Val Lys Glu Lys Arg Asn Lys 
        115                 120                 125             


Thr Thr Glu Glu Asn Gly Glu Lys Gly Thr Glu Ile Phe Arg Ala Ser 
    130                 135                 140                 


Ala Val Ile Pro Ser Lys Asp Lys Ala Ala Phe Phe Leu Ser Tyr Glu 
145                 150                 155                 160 


Glu Leu Leu Gln Arg Arg Leu Gly Lys Tyr Glu His Ser Ile Ser Val 
                165                 170                 175     


Arg Pro Gln Gln Leu Ser Gly Arg Leu Ser Val Asp Val Asn Ile Leu 
            180                 185                 190         


Glu Ser Ala Gly Ile Ala Ser Leu Glu Val Leu Pro Leu His Asn Ser 
        195                 200                 205             


Arg Gln Arg Gly Ser Gly Arg Gly Glu Asp Asp Ser Gly Pro Pro Pro 
    210                 215                 220                 


Ser Thr Val Ile Asn Gln Asn Glu Thr Phe Ala Asn Ile Ile Phe Lys 
225                 230                 235                 240 


Pro Thr Val Val Gln Gln Ala Arg Ile Ala Gln Asn Gly Ile Leu Gly 
                245                 250                 255     


Asp Phe Ile Ile Arg Tyr Asp Val Asn Arg Glu Gln Ser Ile Gly Asp 
            260                 265                 270         


Ile Gln Val Leu Asn Gly Tyr Phe Val His Tyr Phe Ala Pro Lys Asp 
        275                 280                 285             


Leu Pro Pro Leu Pro Lys Asn Val Val Phe Val Leu Asp Ser Ser Ala 
    290                 295                 300                 


Ser Met Val Gly Thr Lys Leu Arg Gln Thr Lys Asp Ala Leu Phe Thr 
305                 310                 315                 320 


Ile Leu His Asp Leu Arg Pro Gln Asp Arg Phe Ser Ile Ile Gly Phe 
                325                 330                 335     


Ser Asn Arg Ile Lys Val Trp Lys Asp His Leu Ile Ser Val Thr Pro 
            340                 345                 350         


Asp Ser Ile Arg Asp Gly Lys Val Tyr Ile His His Met Ser Pro Thr 
        355                 360                 365             


Gly Gly Thr Asp Ile Asn Gly Ala Leu Gln Arg Ala Ile Arg Leu Leu 
    370                 375                 380                 


Asn Lys Tyr Val Ala His Ser Gly Ile Gly Asp Arg Ser Val Ser Leu 
385                 390                 395                 400 


Ile Val Phe Leu Thr Asp Gly Lys Pro Thr Val Gly Glu Thr His Thr 
                405                 410                 415     


Leu Lys Ile Leu Asn Asn Thr Arg Glu Ala Ala Arg Gly Gln Val Cys 
            420                 425                 430         


Ile Phe Thr Ile Gly Ile Gly Asn Asp Val Asp Phe Arg Leu Leu Glu 
        435                 440                 445             


Lys Leu Ser Leu Glu Asn Cys Gly Leu Thr Arg Arg Val His Glu Glu 
    450                 455                 460                 


Glu Asp Ala Gly Ser Gln Leu Ile Gly Phe Tyr Asp Glu Ile Arg Thr 
465                 470                 475                 480 


Pro Leu Leu Ser Asp Ile Arg Ile Asp Tyr Pro Pro Ser Ser Val Val 
                485                 490                 495     


Gln Ala Thr Lys Thr Leu Phe Pro Asn Tyr Phe Asn Gly Ser Glu Ile 
            500                 505                 510         


Ile Ile Ala Gly Lys Leu Val Asp Arg Lys Leu Asp His Leu His Val 
        515                 520                 525             


Glu Val Thr Ala Ser Asn Ser Lys Lys Phe Ile Ile Leu Lys Thr Asp 
    530                 535                 540                 


Val Pro Val Arg Pro Gln Lys Ala Gly Lys Asp Val Thr Gly Ser Pro 
545                 550                 555                 560 


Arg Pro Gly Gly Asp Gly Glu Gly Asp Thr Asn His Ile Glu Arg Leu 
                565                 570                 575     


Trp Ser Tyr Leu Thr Thr Lys Glu Leu Leu Ser Ser Trp Leu Gln Ser 
            580                 585                 590         


Asp Asp Glu Pro Glu Lys Glu Arg Leu Arg Gln Arg Ala Gln Ala Leu 
        595                 600                 605             


Ala Val Ser Tyr Arg Phe Leu Thr Pro Phe Thr Ser Met Lys Leu Arg 
    610                 615                 620                 


Gly Pro Val Pro Arg Met Asp Gly Leu Glu Glu Ala His Gly Met Ser 
625                 630                 635                 640 


Ala Ala Met Gly Pro Glu Pro Val Val Gln Ser Val Arg Gly Ala Gly 
                645                 650                 655     


Thr Gln Pro Gly Pro Leu Leu Lys Lys Pro Tyr Gln Pro Arg Ile Lys 
            660                 665                 670         


Ile Ser Lys Thr Ser Val Arg Gly Phe Arg Arg Glu Glu Gln Ile Phe 
        675                 680                 685             


Ser Asn Val Met Lys Phe Pro Phe Ala Ser Ile Leu Glu Leu 
    690                 695                 700         


<210>  2470
<211>  6331
<212>  DNA
<213>  Homosapiens

<400>  2470
gtcccgcagt ggctggagcc ctgggcgctg caaagcgtgt cccgccgggt ccccgagcgt     60

cccgcgccct cgccccgcca tgctcctgct gctggggctg tgcctggggc tgtccctgtg    120

tgtggggtcg caggaagagg cgcagagctg gggccactct tcggagcagg atggactcag    180

ggtcccgagg caagtcagac tgttgcagag gctgaaaacc aaacctttga tgacagaatt    240

ctcagtgaag tctaccatca tttcccgtta tgccttcact acggtttcct gcagaatgct    300

gaacagagct tctgaagacc aggacattga gttccagatg cagattccag ctgcagcttt    360

catcaccaac ttcactatgc ttattggaga caaggtgtat cagggcgaaa ttacagagag    420

agaaaagaag agtggtgata gggtaaaaga gaaaaggaat aaaaccacag aagaaaatgg    480

agagaagggg actgaaatat tcagagcttc tgcagtgatt cccagcaagg acaaagccgc    540

ctttttcctg agttatgagg agcttctgca gaggcgcctg ggcaagtacg agcacagcat    600

cagcgtgcgg ccccagcagc tgtccgggag gctgagcgtg gacgtgaata tcctggagag    660

cgcgggcatc gcatccctgg aggtgctgcc gcttcacaac agcaggcaga ggggcagtgg    720

gcgcggggaa gatgattctg ggcctccccc atctactgtc attaaccaaa atgaaacatt    780

tgccaacata atttttaaac ctactgtagt acaacaagcc aggattgccc agaatggaat    840

tttgggagac tttatcatta gatatgacgt caatagagaa cagagcattg gggacatcca    900

ggttctaaat ggctattttg tgcactactt tgctcctaaa gaccttcctc ctttacccaa    960

gaatgtggta ttcgtgcttg acagcagtgc ttctatggtg ggaaccaaac tccggcagac   1020

caaggatgcc ctcttcacaa ttctccatga cctccgaccc caggaccgtt tcagtatcat   1080

tggattttcc aaccggatca aagtatggaa ggaccacttg atatcagtca ctccagacag   1140

catcagggat gggaaagtgt acattcacca tatgtcaccc actggaggca cagacatcaa   1200

cggggccctg cagagggcca tcaggctcct caacaagtac gtggcccaca gtggcattgg   1260

agaccggagc gtgtccctca tcgtcttcct gacggatggg aagcccacgg tcggggagac   1320

gcacaccctc aagatcctca acaacacccg agaggccgcc cgaggccaag tctgcatctt   1380

caccattggc atcggcaacg acgtggactt caggctgctg gagaaactgt cgctggagaa   1440

ctgtggcctc acacggcgcg tgcacgagga ggaggacgca ggctcgcagc tcatcgggtt   1500

ctacgatgaa atcaggaccc cgctcctctc tgacatccgc atcgattatc cccccagctc   1560

agtggtgcag gccaccaaga ccctgttccc caactacttc aacggctcgg agatcatcat   1620

tgcggggaag ctggtggaca ggaagctgga tcacctgcac gtggaggtca ccgccagcaa   1680

cagtaagaaa ttcatcatcc tgaagacaga tgtgcctgtg cggcctcaga aggcagggaa   1740

agatgtcaca ggaagcccca ggcctggagg cgatggagag ggggacacca accacatcga   1800

gcgtctctgg agctacctca ccacaaagga gctgctgagc tcctggctgc aaagtgacga   1860

tgaaccggag aaggagcggc tgcggcagcg ggcccaggcc ctggctgtga gctaccgctt   1920

cctcactccc ttcacctcca tgaagctgag ggggccggtc ccacgcatgg atggcctgga   1980

ggaggcccac ggcatgtcgg ctgccatggg acccgaaccg gtggtgcaga gcgtgcgagg   2040

agctggcacg cagccaggac ctttgctcaa gaagccatac cagccaagaa ttaaaatctc   2100

taaaacatca gtggatggtg atccccactt tgttgtggat ttccccctga gcagactcac   2160

cgtgtgcttc aacattgatg ggcagcccgg ggacatcctc aggctggtct ctgatcacag   2220

ggactctggt gtcacagtga acggagagtt aattggggca cccgcccctc caaatggcca   2280

caagaaacag cgcacttact tgcgcactat caccatcctc atcaacaagc cagagagatc   2340

ttatctcgag atcacaccga gcagagtcat cttggatggt ggggacagac tggtgctccc   2400

ctgcaaccag agtgtggtgg tggggagctg ggggctggag gtgtccgtgt ctgccaacgc   2460

caatgtcacc gtcaccatcc agggctccat agcctttgtc atcctcatcc acctctacaa   2520

aaagccggcg cccttccagc gacaccacct gggtttctac attgccaaca gcgagggcct   2580

ttccagcaac tgccacggac tgctgggtca gttcctgaat caggatgcca gactcacaga   2640

agaccctgca gggcccagcc agaacctcac tcaccctctg ctccttcagg tgggagaggg   2700

gcctgaggcc gtcctaacag tgaaaggcca ccaagtccca gtggtctgga agcaaaggaa   2760

gatttacaac ggggaagagc agatagactg ctggtttgcc aggaacaatg ccgccaaact   2820

gattgacggg gagtacaagg attacctggc atcccatcca tttgacacag ggatggacac   2880

ttggccgggg aatgtccagg gagctctgaa gctggcagcc ttaaagatgc aagtgcatga   2940

aggacagtga tgtggggagg ccgtggggca gctcttttca tggcttgtac acgcctcagc   3000

tcctggcaat tagctggact ccatgaccca cccctggtgc agcatagatc cgacgtctgt   3060

ctgggcgaag ggtaggggtg ggtaggggcg ggaagcctga gtgcaaatgt catttccctc   3120

tactgcctct tcctgcctct ccccaccctg cccacatcca cagaggggag agaagggtca   3180

tagctaaatg caacaaagtc tgtatcttgt cccaacctgc ttttctgttc tgttagcata   3240

tcataaagta agcctttctg gtgaaggaag gttgctatga aacttttttt cttggtggaa   3300

atggacaagt ttaggcactc tgctttttgc cttacactaa tgcttagaaa gctgtctttt   3360

cagtggtgtt gcagccccca gatgtgtggc caacctctgc tgcaaaggaa tctcttgctg   3420

agtccaggcc accaatcagg caaatagccc atacatttga tcgttgtaaa ccatgaagtc   3480

ttttcttgca agacgttttt cttctgctgt ggtatcttgc ccttaaaaat tagttttcat   3540

taaaaagaaa tttgattgaa aatagaaaca tctacagctc agatactgat ctctttctag   3600

tgggctttgt aaaccacttg actttgctaa tggctattct ccaatttgtt ccaataagct   3660

aagggctttt catacacagg acaactccat gtggttgatt ttactggcat gtcttggtga   3720

cgaagagttg gccaagtgaa tgatgcatct tttacttgga gctctccagc ctttgtcata   3780

gttcccagac cttttttcct tgtggtcatc caggaggtga tcaattacat gtgcacagtg   3840

ctaggacggg aggcagagcc ggctcagagc aggtccacca gcccacctat agcaggaagc   3900

gtgtcggtgc ttaggaaatc taggacttcc agcttccctc atgtcagata gaaaaaaagt   3960

caggaaacca gctcgtggac aggggctttg gttccaaaac ttggacaaac ctgatgcctt   4020

aaggaaaagg ttaagatgag agggggcttc cagagtcaat gaacgtcacc cttcagccga   4080

cggataccgg gagcgcttgg gcaaaacagc agagaaagaa agactgtggt cggggaagtg   4140

gaatgcttcg atgcaggcca gagttcaagg ctctggggct ggcctcacaa gaggcttctt   4200

ccacggggct tgacaccaga gcagcccccg cgtgaaatga gaaggcatgc ttagcactgg   4260

gaggaaaagc tgagttaaga aaattcttta tcatgtttgc cttccctggg gaaacattca   4320

ggcagtaaaa tgacatccac gtgttcctgt cggacgcagc ggcttcggga acaagttagc   4380

gctgggggac tatctgggct cgtctctctc tgcttcgtga acccaccaca ccagggcctg   4440

tctgctgtgc tatttatttg ccttccgtct tcccaacctc agctgcctgt attcatgcca   4500

gaggtgcaaa ggctgccagc cagtgctgct gacagatgct ttcagactgt agagctcaga   4560

gaaagggagc ggcagctaga ggtagccagg gagctggcca ggctccccgg ggccttccta   4620

ttatgtaaat cccagctgga cagacagccc tggagccagg tggccctgtc ccctgtggag   4680

cacttggagc agtgatctgt tgttccaggt gtaagtctcg acactgcaga aatgaggacg   4740

ttattaggaa agaccagttc ctactgcctg tgttgctact ttaagagctg agaaaaacat   4800

tccaatgagc tatccatagc taacttgctt gctcagaaaa acataagtaa caaagttgag   4860

ctttcatttt taaaaattat attttacttt agaaaaatat cacctttttt cttcctcttc   4920

tttacgtgta gatctttttt tttttttcaa atggggtcag tacctgaaag cccgaaaccc   4980

cataccaagc ttatagttag gacctttgca tttgataaaa aaaaatatag tattttctgt   5040

tgtccagaaa atcttcccag atagggaaac tgaggcagag agtgccgtgg agtggttttt   5100

gccaagtcat acaacatact taatgcaggg ctacactgaa cctccagaat cattttgttt   5160

gctttgaccc tgtttcacca tctgggcaat catttatttt ccttgagcat ttataaacca   5220

gggcgagggt tgttccaaaa tgagtaattg aatgagatga agaaatatgt cataattaga   5280

ggagataaat ctccttgtta tcacaatagt taatgtgtca tgatcactga ctaactggga   5340

ccttgaacaa gtcagcatct ctgcctttca aaatgaagga acattgttct ctatcctccc   5400

ctgacccccc acggccccat gctaggtgca ccatcttcct ccatttgact ttttaatgct   5460

ttacaacttc aggctaaagg gaggggatgt tgggaggaga aaccatcaca agattccctc   5520

ggtgccacag ctgtgctgag gaggccgggg actgggaatc ggagtgggca cctctgtgtt   5580

tctctaggga gtaacattca acatttaatt gaatcgtgta tcctgatagg tggattagga   5640

acaggattca ttcctttaac tttaactttt ggctaaacga catgccttgg attgagtgta   5700

tatgtcttcc ccaaattcat atgttgaagc ttaaatcctg aatgtgatgg ttcttggaat   5760

tgggaccttt ggaaggttat tgggtcttga gggcagagcc ctcacgaatg ggattaaggc   5820

ccttataaga agagacatgg ggccaggtgc agtggctcac acctgtaatc ccaacatttt   5880

gggaggccga gaagggtgga tcatgaggtc aggagatgga gaccatcctg gccaacatgg   5940

tgaaacctcg tctctactaa aaatacaaaa attagctggg cgtggtggtg cgtgcctgta   6000

gttccagcta cttgggaggc tgaggcagga gaatcgcttg aaccaggcag tcggaacttg   6060

tagtgagcca agatcacgcc actgcactcc agctggagtg acagagccaa actccgtcaa   6120

aaaaaaacaa aacaaaacaa aaaaaagaca tgggagagat ggtgtttttc ctctccacca   6180

cctggggata cgatgagaag atggccacct gcaagccagg aagacggccc tcaccagaca   6240

ccatgtctgc tggcaccttg atcttggacc tcccagcctc cagaactgtg agaaataaat   6300

gtgttttgtt taagctaaaa aaaaaaaaaa a                                  6331


<210>  2471
<211>  956
<212>  PRT
<213>  Homosapiens

<400>  2471

Met Leu Leu Leu Leu Gly Leu Cys Leu Gly Leu Ser Leu Cys Val Gly 
1               5                   10                  15      


Ser Gln Glu Glu Ala Gln Ser Trp Gly His Ser Ser Glu Gln Asp Gly 
            20                  25                  30          


Leu Arg Val Pro Arg Gln Val Arg Leu Leu Gln Arg Leu Lys Thr Lys 
        35                  40                  45              


Pro Leu Met Thr Glu Phe Ser Val Lys Ser Thr Ile Ile Ser Arg Tyr 
    50                  55                  60                  


Ala Phe Thr Thr Val Ser Cys Arg Met Leu Asn Arg Ala Ser Glu Asp 
65                  70                  75                  80  


Gln Asp Ile Glu Phe Gln Met Gln Ile Pro Ala Ala Ala Phe Ile Thr 
                85                  90                  95      


Asn Phe Thr Met Leu Ile Gly Asp Lys Val Tyr Gln Gly Glu Ile Thr 
            100                 105                 110         


Glu Arg Glu Lys Lys Ser Gly Asp Arg Val Lys Glu Lys Arg Asn Lys 
        115                 120                 125             


Thr Thr Glu Glu Asn Gly Glu Lys Gly Thr Glu Ile Phe Arg Ala Ser 
    130                 135                 140                 


Ala Val Ile Pro Ser Lys Asp Lys Ala Ala Phe Phe Leu Ser Tyr Glu 
145                 150                 155                 160 


Glu Leu Leu Gln Arg Arg Leu Gly Lys Tyr Glu His Ser Ile Ser Val 
                165                 170                 175     


Arg Pro Gln Gln Leu Ser Gly Arg Leu Ser Val Asp Val Asn Ile Leu 
            180                 185                 190         


Glu Ser Ala Gly Ile Ala Ser Leu Glu Val Leu Pro Leu His Asn Ser 
        195                 200                 205             


Arg Gln Arg Gly Ser Gly Arg Gly Glu Asp Asp Ser Gly Pro Pro Pro 
    210                 215                 220                 


Ser Thr Val Ile Asn Gln Asn Glu Thr Phe Ala Asn Ile Ile Phe Lys 
225                 230                 235                 240 


Pro Thr Val Val Gln Gln Ala Arg Ile Ala Gln Asn Gly Ile Leu Gly 
                245                 250                 255     


Asp Phe Ile Ile Arg Tyr Asp Val Asn Arg Glu Gln Ser Ile Gly Asp 
            260                 265                 270         


Ile Gln Val Leu Asn Gly Tyr Phe Val His Tyr Phe Ala Pro Lys Asp 
        275                 280                 285             


Leu Pro Pro Leu Pro Lys Asn Val Val Phe Val Leu Asp Ser Ser Ala 
    290                 295                 300                 


Ser Met Val Gly Thr Lys Leu Arg Gln Thr Lys Asp Ala Leu Phe Thr 
305                 310                 315                 320 


Ile Leu His Asp Leu Arg Pro Gln Asp Arg Phe Ser Ile Ile Gly Phe 
                325                 330                 335     


Ser Asn Arg Ile Lys Val Trp Lys Asp His Leu Ile Ser Val Thr Pro 
            340                 345                 350         


Asp Ser Ile Arg Asp Gly Lys Val Tyr Ile His His Met Ser Pro Thr 
        355                 360                 365             


Gly Gly Thr Asp Ile Asn Gly Ala Leu Gln Arg Ala Ile Arg Leu Leu 
    370                 375                 380                 


Asn Lys Tyr Val Ala His Ser Gly Ile Gly Asp Arg Ser Val Ser Leu 
385                 390                 395                 400 


Ile Val Phe Leu Thr Asp Gly Lys Pro Thr Val Gly Glu Thr His Thr 
                405                 410                 415     


Leu Lys Ile Leu Asn Asn Thr Arg Glu Ala Ala Arg Gly Gln Val Cys 
            420                 425                 430         


Ile Phe Thr Ile Gly Ile Gly Asn Asp Val Asp Phe Arg Leu Leu Glu 
        435                 440                 445             


Lys Leu Ser Leu Glu Asn Cys Gly Leu Thr Arg Arg Val His Glu Glu 
    450                 455                 460                 


Glu Asp Ala Gly Ser Gln Leu Ile Gly Phe Tyr Asp Glu Ile Arg Thr 
465                 470                 475                 480 


Pro Leu Leu Ser Asp Ile Arg Ile Asp Tyr Pro Pro Ser Ser Val Val 
                485                 490                 495     


Gln Ala Thr Lys Thr Leu Phe Pro Asn Tyr Phe Asn Gly Ser Glu Ile 
            500                 505                 510         


Ile Ile Ala Gly Lys Leu Val Asp Arg Lys Leu Asp His Leu His Val 
        515                 520                 525             


Glu Val Thr Ala Ser Asn Ser Lys Lys Phe Ile Ile Leu Lys Thr Asp 
    530                 535                 540                 


Val Pro Val Arg Pro Gln Lys Ala Gly Lys Asp Val Thr Gly Ser Pro 
545                 550                 555                 560 


Arg Pro Gly Gly Asp Gly Glu Gly Asp Thr Asn His Ile Glu Arg Leu 
                565                 570                 575     


Trp Ser Tyr Leu Thr Thr Lys Glu Leu Leu Ser Ser Trp Leu Gln Ser 
            580                 585                 590         


Asp Asp Glu Pro Glu Lys Glu Arg Leu Arg Gln Arg Ala Gln Ala Leu 
        595                 600                 605             


Ala Val Ser Tyr Arg Phe Leu Thr Pro Phe Thr Ser Met Lys Leu Arg 
    610                 615                 620                 


Gly Pro Val Pro Arg Met Asp Gly Leu Glu Glu Ala His Gly Met Ser 
625                 630                 635                 640 


Ala Ala Met Gly Pro Glu Pro Val Val Gln Ser Val Arg Gly Ala Gly 
                645                 650                 655     


Thr Gln Pro Gly Pro Leu Leu Lys Lys Pro Tyr Gln Pro Arg Ile Lys 
            660                 665                 670         


Ile Ser Lys Thr Ser Val Asp Gly Asp Pro His Phe Val Val Asp Phe 
        675                 680                 685             


Pro Leu Ser Arg Leu Thr Val Cys Phe Asn Ile Asp Gly Gln Pro Gly 
    690                 695                 700                 


Asp Ile Leu Arg Leu Val Ser Asp His Arg Asp Ser Gly Val Thr Val 
705                 710                 715                 720 


Asn Gly Glu Leu Ile Gly Ala Pro Ala Pro Pro Asn Gly His Lys Lys 
                725                 730                 735     


Gln Arg Thr Tyr Leu Arg Thr Ile Thr Ile Leu Ile Asn Lys Pro Glu 
            740                 745                 750         


Arg Ser Tyr Leu Glu Ile Thr Pro Ser Arg Val Ile Leu Asp Gly Gly 
        755                 760                 765             


Asp Arg Leu Val Leu Pro Cys Asn Gln Ser Val Val Val Gly Ser Trp 
    770                 775                 780                 


Gly Leu Glu Val Ser Val Ser Ala Asn Ala Asn Val Thr Val Thr Ile 
785                 790                 795                 800 


Gln Gly Ser Ile Ala Phe Val Ile Leu Ile His Leu Tyr Lys Lys Pro 
                805                 810                 815     


Ala Pro Phe Gln Arg His His Leu Gly Phe Tyr Ile Ala Asn Ser Glu 
            820                 825                 830         


Gly Leu Ser Ser Asn Cys His Gly Leu Leu Gly Gln Phe Leu Asn Gln 
        835                 840                 845             


Asp Ala Arg Leu Thr Glu Asp Pro Ala Gly Pro Ser Gln Asn Leu Thr 
    850                 855                 860                 


His Pro Leu Leu Leu Gln Val Gly Glu Gly Pro Glu Ala Val Leu Thr 
865                 870                 875                 880 


Val Lys Gly His Gln Val Pro Val Val Trp Lys Gln Arg Lys Ile Tyr 
                885                 890                 895     


Asn Gly Glu Glu Gln Ile Asp Cys Trp Phe Ala Arg Asn Asn Ala Ala 
            900                 905                 910         


Lys Leu Ile Asp Gly Glu Tyr Lys Asp Tyr Leu Ala Ser His Pro Phe 
        915                 920                 925             


Asp Thr Gly Met Asp Thr Trp Pro Gly Asn Val Gln Gly Ala Leu Lys 
    930                 935                 940                 


Leu Ala Ala Leu Lys Met Gln Val His Glu Gly Gln 
945                 950                 955     


<210>  2472
<211>  5671
<212>  DNA
<213>  Homosapiens

<400>  2472
gacgtgttcg ctttgcgttt gccttctgcg tgattgtaag tttcccgagg cttccccagc     60

catgcggaac tatgattctg ggcctccccc atctactgtc attaaccaaa atgaaacatt    120

tgccaacata atttttaaac ctactgtagt acaacaagcc aggattgccc agaatggaat    180

tttgggagac tttatcatta gatatgacgt caatagagaa cagagcattg gggacatcca    240

ggttctaaat ggctattttg tgcactactt tgctcctaaa gaccttcctc ctttacccaa    300

gaatgtggta ttcgtgcttg acagcagtgc ttctatggtg ggaaccaaac tccggcagac    360

caaggatgcc ctcttcacaa ttctccatga cctccgaccc caggaccgtt tcagtatcat    420

tggattttcc aaccggatca aagtatggaa ggaccacttg atatcagtca ctccagacag    480

catcagggat gggaaagtgt acattcacca tatgtcaccc actggaggca cagacatcaa    540

cggggccctg cagagggcca tcaggctcct caacaagtac gtggcccaca gtggcattgg    600

agaccggagc gtgtccctca tcgtcttcct gacggatggg aagcccacgg tcggggagac    660

gcacaccctc aagatcctca acaacacccg agaggccgcc cgaggccaag tctgcatctt    720

caccattggc atcggcaacg acgtggactt caggctgctg gagaaactgt cgctggagaa    780

ctgtggcctc acacggcgcg tgcacgagga ggaggacgca ggctcgcagc tcatcgggtt    840

ctacgatgaa atcaggaccc cgctcctctc tgacatccgc atcgattatc cccccagctc    900

agtggtgcag gccaccaaga ccctgttccc caactacttc aacggctcgg agatcatcat    960

tgcggggaag ctggtggaca ggaagctgga tcacctgcac gtggaggtca ccgccagcaa   1020

cagtaagaaa ttcatcatcc tgaagacaga tgtgcctgtg cggcctcaga aggcagggaa   1080

agatgtcaca ggaagcccca ggcctggagg cgatggagag ggggacacca accacatcga   1140

gcgtctctgg agctacctca ccacaaagga gctgctgagc tcctggctgc aaagtgacga   1200

tgaaccggag aaggagcggc tgcggcagcg ggcccaggcc ctggctgtga gctaccgctt   1260

cctcactccc ttcacctcca tgaagctgag ggggccggtc ccacgcatgg atggcctgga   1320

ggaggcccac ggcatgtcgg ctgccatggg acccgaaccg gtggtgcaga gcgtgcgagg   1380

agctggcacg cagccaggac ctttgctcaa gaagccatac cagccaagaa ttaaaatctc   1440

taaaacatca gtggatggtg atccccactt tgttgtggat ttccccctga gcagactcac   1500

cgtgtgcttc aacattgatg ggcagcccgg ggacatcctc aggctggtct ctgatcacag   1560

ggactctggt gtcacagtga acggagagtt aattggggca cccgcccctc caaatggcca   1620

caagaaacag cgcacttact tgcgcactat caccatcctc atcaacaagc cagagagatc   1680

ttatctcgag atcacaccga gcagagtcat cttggatggt ggggacagac tggtgctccc   1740

ctgcaaccag agtgtggtgg tggggagctg ggggctggag gtgtccgtgt ctgccaacgc   1800

caatgtcacc gtcaccatcc agggctccat agcctttgtc atcctcatcc acctctacaa   1860

aaagccggcg cccttccagc gacaccacct gggtttctac attgccaaca gcgagggcct   1920

ttccagcaac tgccacggac tgctgggtca gttcctgaat caggatgcca gactcacaga   1980

agaccctgca gggcccagcc agaacctcac tcaccctctg ctccttcagg tgggagaggg   2040

gcctgaggcc gtcctaacag tgaaaggcca ccaagtccca gtggtctgga agcaaaggaa   2100

gatttacaac ggggaagagc agatagactg ctggtttgcc aggaacaatg ccgccaaact   2160

gattgacggg gagtacaagg attacctggc atcccatcca tttgacacag ggatggacac   2220

ttggccgggg aatgtccagg gagctctgaa gctggcagcc ttaaagatgc aagtgcatga   2280

aggacagtga tgtggggagg ccgtggggca gctcttttca tggcttgtac acgcctcagc   2340

tcctggcaat tagctggact ccatgaccca cccctggtgc agcatagatc cgacgtctgt   2400

ctgggcgaag ggtaggggtg ggtaggggcg ggaagcctga gtgcaaatgt catttccctc   2460

tactgcctct tcctgcctct ccccaccctg cccacatcca cagaggggag agaagggtca   2520

tagctaaatg caacaaagtc tgtatcttgt cccaacctgc ttttctgttc tgttagcata   2580

tcataaagta agcctttctg gtgaaggaag gttgctatga aacttttttt cttggtggaa   2640

atggacaagt ttaggcactc tgctttttgc cttacactaa tgcttagaaa gctgtctttt   2700

cagtggtgtt gcagccccca gatgtgtggc caacctctgc tgcaaaggaa tctcttgctg   2760

agtccaggcc accaatcagg caaatagccc atacatttga tcgttgtaaa ccatgaagtc   2820

ttttcttgca agacgttttt cttctgctgt ggtatcttgc ccttaaaaat tagttttcat   2880

taaaaagaaa tttgattgaa aatagaaaca tctacagctc agatactgat ctctttctag   2940

tgggctttgt aaaccacttg actttgctaa tggctattct ccaatttgtt ccaataagct   3000

aagggctttt catacacagg acaactccat gtggttgatt ttactggcat gtcttggtga   3060

cgaagagttg gccaagtgaa tgatgcatct tttacttgga gctctccagc ctttgtcata   3120

gttcccagac cttttttcct tgtggtcatc caggaggtga tcaattacat gtgcacagtg   3180

ctaggacggg aggcagagcc ggctcagagc aggtccacca gcccacctat agcaggaagc   3240

gtgtcggtgc ttaggaaatc taggacttcc agcttccctc atgtcagata gaaaaaaagt   3300

caggaaacca gctcgtggac aggggctttg gttccaaaac ttggacaaac ctgatgcctt   3360

aaggaaaagg ttaagatgag agggggcttc cagagtcaat gaacgtcacc cttcagccga   3420

cggataccgg gagcgcttgg gcaaaacagc agagaaagaa agactgtggt cggggaagtg   3480

gaatgcttcg atgcaggcca gagttcaagg ctctggggct ggcctcacaa gaggcttctt   3540

ccacggggct tgacaccaga gcagcccccg cgtgaaatga gaaggcatgc ttagcactgg   3600

gaggaaaagc tgagttaaga aaattcttta tcatgtttgc cttccctggg gaaacattca   3660

ggcagtaaaa tgacatccac gtgttcctgt cggacgcagc ggcttcggga acaagttagc   3720

gctgggggac tatctgggct cgtctctctc tgcttcgtga acccaccaca ccagggcctg   3780

tctgctgtgc tatttatttg ccttccgtct tcccaacctc agctgcctgt attcatgcca   3840

gaggtgcaaa ggctgccagc cagtgctgct gacagatgct ttcagactgt agagctcaga   3900

gaaagggagc ggcagctaga ggtagccagg gagctggcca ggctccccgg ggccttccta   3960

ttatgtaaat cccagctgga cagacagccc tggagccagg tggccctgtc ccctgtggag   4020

cacttggagc agtgatctgt tgttccaggt gtaagtctcg acactgcaga aatgaggacg   4080

ttattaggaa agaccagttc ctactgcctg tgttgctact ttaagagctg agaaaaacat   4140

tccaatgagc tatccatagc taacttgctt gctcagaaaa acataagtaa caaagttgag   4200

ctttcatttt taaaaattat attttacttt agaaaaatat cacctttttt cttcctcttc   4260

tttacgtgta gatctttttt tttttttcaa atggggtcag tacctgaaag cccgaaaccc   4320

cataccaagc ttatagttag gacctttgca tttgataaaa aaaaatatag tattttctgt   4380

tgtccagaaa atcttcccag atagggaaac tgaggcagag agtgccgtgg agtggttttt   4440

gccaagtcat acaacatact taatgcaggg ctacactgaa cctccagaat cattttgttt   4500

gctttgaccc tgtttcacca tctgggcaat catttatttt ccttgagcat ttataaacca   4560

gggcgagggt tgttccaaaa tgagtaattg aatgagatga agaaatatgt cataattaga   4620

ggagataaat ctccttgtta tcacaatagt taatgtgtca tgatcactga ctaactggga   4680

ccttgaacaa gtcagcatct ctgcctttca aaatgaagga acattgttct ctatcctccc   4740

ctgacccccc acggccccat gctaggtgca ccatcttcct ccatttgact ttttaatgct   4800

ttacaacttc aggctaaagg gaggggatgt tgggaggaga aaccatcaca agattccctc   4860

ggtgccacag ctgtgctgag gaggccgggg actgggaatc ggagtgggca cctctgtgtt   4920

tctctaggga gtaacattca acatttaatt gaatcgtgta tcctgatagg tggattagga   4980

acaggattca ttcctttaac tttaactttt ggctaaacga catgccttgg attgagtgta   5040

tatgtcttcc ccaaattcat atgttgaagc ttaaatcctg aatgtgatgg ttcttggaat   5100

tgggaccttt ggaaggttat tgggtcttga gggcagagcc ctcacgaatg ggattaaggc   5160

ccttataaga agagacatgg ggccaggtgc agtggctcac acctgtaatc ccaacatttt   5220

gggaggccga gaagggtgga tcatgaggtc aggagatgga gaccatcctg gccaacatgg   5280

tgaaacctcg tctctactaa aaatacaaaa attagctggg cgtggtggtg cgtgcctgta   5340

gttccagcta cttgggaggc tgaggcagga gaatcgcttg aaccaggcag tcggaacttg   5400

tagtgagcca agatcacgcc actgcactcc agctggagtg acagagccaa actccgtcaa   5460

aaaaaaacaa aacaaaacaa aaaaaagaca tgggagagat ggtgtttttc ctctccacca   5520

cctggggata cgatgagaag atggccacct gcaagccagg aagacggccc tcaccagaca   5580

ccatgtctgc tggcaccttg atcttggacc tcccagcctc cagaactgtg agaaataaat   5640

gtgttttgtt taagctaaaa aaaaaaaaaa a                                  5671


<210>  2473
<211>  742
<212>  PRT
<213>  Homosapiens

<400>  2473

Met Arg Asn Tyr Asp Ser Gly Pro Pro Pro Ser Thr Val Ile Asn Gln 
1               5                   10                  15      


Asn Glu Thr Phe Ala Asn Ile Ile Phe Lys Pro Thr Val Val Gln Gln 
            20                  25                  30          


Ala Arg Ile Ala Gln Asn Gly Ile Leu Gly Asp Phe Ile Ile Arg Tyr 
        35                  40                  45              


Asp Val Asn Arg Glu Gln Ser Ile Gly Asp Ile Gln Val Leu Asn Gly 
    50                  55                  60                  


Tyr Phe Val His Tyr Phe Ala Pro Lys Asp Leu Pro Pro Leu Pro Lys 
65                  70                  75                  80  


Asn Val Val Phe Val Leu Asp Ser Ser Ala Ser Met Val Gly Thr Lys 
                85                  90                  95      


Leu Arg Gln Thr Lys Asp Ala Leu Phe Thr Ile Leu His Asp Leu Arg 
            100                 105                 110         


Pro Gln Asp Arg Phe Ser Ile Ile Gly Phe Ser Asn Arg Ile Lys Val 
        115                 120                 125             


Trp Lys Asp His Leu Ile Ser Val Thr Pro Asp Ser Ile Arg Asp Gly 
    130                 135                 140                 


Lys Val Tyr Ile His His Met Ser Pro Thr Gly Gly Thr Asp Ile Asn 
145                 150                 155                 160 


Gly Ala Leu Gln Arg Ala Ile Arg Leu Leu Asn Lys Tyr Val Ala His 
                165                 170                 175     


Ser Gly Ile Gly Asp Arg Ser Val Ser Leu Ile Val Phe Leu Thr Asp 
            180                 185                 190         


Gly Lys Pro Thr Val Gly Glu Thr His Thr Leu Lys Ile Leu Asn Asn 
        195                 200                 205             


Thr Arg Glu Ala Ala Arg Gly Gln Val Cys Ile Phe Thr Ile Gly Ile 
    210                 215                 220                 


Gly Asn Asp Val Asp Phe Arg Leu Leu Glu Lys Leu Ser Leu Glu Asn 
225                 230                 235                 240 


Cys Gly Leu Thr Arg Arg Val His Glu Glu Glu Asp Ala Gly Ser Gln 
                245                 250                 255     


Leu Ile Gly Phe Tyr Asp Glu Ile Arg Thr Pro Leu Leu Ser Asp Ile 
            260                 265                 270         


Arg Ile Asp Tyr Pro Pro Ser Ser Val Val Gln Ala Thr Lys Thr Leu 
        275                 280                 285             


Phe Pro Asn Tyr Phe Asn Gly Ser Glu Ile Ile Ile Ala Gly Lys Leu 
    290                 295                 300                 


Val Asp Arg Lys Leu Asp His Leu His Val Glu Val Thr Ala Ser Asn 
305                 310                 315                 320 


Ser Lys Lys Phe Ile Ile Leu Lys Thr Asp Val Pro Val Arg Pro Gln 
                325                 330                 335     


Lys Ala Gly Lys Asp Val Thr Gly Ser Pro Arg Pro Gly Gly Asp Gly 
            340                 345                 350         


Glu Gly Asp Thr Asn His Ile Glu Arg Leu Trp Ser Tyr Leu Thr Thr 
        355                 360                 365             


Lys Glu Leu Leu Ser Ser Trp Leu Gln Ser Asp Asp Glu Pro Glu Lys 
    370                 375                 380                 


Glu Arg Leu Arg Gln Arg Ala Gln Ala Leu Ala Val Ser Tyr Arg Phe 
385                 390                 395                 400 


Leu Thr Pro Phe Thr Ser Met Lys Leu Arg Gly Pro Val Pro Arg Met 
                405                 410                 415     


Asp Gly Leu Glu Glu Ala His Gly Met Ser Ala Ala Met Gly Pro Glu 
            420                 425                 430         


Pro Val Val Gln Ser Val Arg Gly Ala Gly Thr Gln Pro Gly Pro Leu 
        435                 440                 445             


Leu Lys Lys Pro Tyr Gln Pro Arg Ile Lys Ile Ser Lys Thr Ser Val 
    450                 455                 460                 


Asp Gly Asp Pro His Phe Val Val Asp Phe Pro Leu Ser Arg Leu Thr 
465                 470                 475                 480 


Val Cys Phe Asn Ile Asp Gly Gln Pro Gly Asp Ile Leu Arg Leu Val 
                485                 490                 495     


Ser Asp His Arg Asp Ser Gly Val Thr Val Asn Gly Glu Leu Ile Gly 
            500                 505                 510         


Ala Pro Ala Pro Pro Asn Gly His Lys Lys Gln Arg Thr Tyr Leu Arg 
        515                 520                 525             


Thr Ile Thr Ile Leu Ile Asn Lys Pro Glu Arg Ser Tyr Leu Glu Ile 
    530                 535                 540                 


Thr Pro Ser Arg Val Ile Leu Asp Gly Gly Asp Arg Leu Val Leu Pro 
545                 550                 555                 560 


Cys Asn Gln Ser Val Val Val Gly Ser Trp Gly Leu Glu Val Ser Val 
                565                 570                 575     


Ser Ala Asn Ala Asn Val Thr Val Thr Ile Gln Gly Ser Ile Ala Phe 
            580                 585                 590         


Val Ile Leu Ile His Leu Tyr Lys Lys Pro Ala Pro Phe Gln Arg His 
        595                 600                 605             


His Leu Gly Phe Tyr Ile Ala Asn Ser Glu Gly Leu Ser Ser Asn Cys 
    610                 615                 620                 


His Gly Leu Leu Gly Gln Phe Leu Asn Gln Asp Ala Arg Leu Thr Glu 
625                 630                 635                 640 


Asp Pro Ala Gly Pro Ser Gln Asn Leu Thr His Pro Leu Leu Leu Gln 
                645                 650                 655     


Val Gly Glu Gly Pro Glu Ala Val Leu Thr Val Lys Gly His Gln Val 
            660                 665                 670         


Pro Val Val Trp Lys Gln Arg Lys Ile Tyr Asn Gly Glu Glu Gln Ile 
        675                 680                 685             


Asp Cys Trp Phe Ala Arg Asn Asn Ala Ala Lys Leu Ile Asp Gly Glu 
    690                 695                 700                 


Tyr Lys Asp Tyr Leu Ala Ser His Pro Phe Asp Thr Gly Met Asp Thr 
705                 710                 715                 720 


Trp Pro Gly Asn Val Gln Gly Ala Leu Lys Leu Ala Ala Leu Lys Met 
                725                 730                 735     


Gln Val His Glu Gly Gln 
            740         


<210>  2474
<211>  3198
<212>  DNA
<213>  Homosapiens

<400>  2474
gtcccaattt tgaacaaagt tagagagttt tttcttcttt tttcttcttt cttaaagcga     60

actgtactcc tctgctgttc ctttgaactt ggttcagtag gaagaagtga tatcctcccc    120

agaccatctg ctttggggag cttggcaaaa ctgtccagca aaatgaaaag actcacgtgc    180

tttttcatct gcttctttct ttctgaagta tcaggcttcg aaatccccat aaatggactt    240

tctgaatttg tagactatga agatcttgtg gaactggccc caggcaaatt tcaattggtg    300

gcagagaacc ggagatatca gagaagcctt ccaggagaat cggaagaaat gatggaagag    360

gttgatcaag taactcttta tagctataaa gtccagtcta ctattacttc tcggatggcc    420

accaccatga tccagagcaa agtggtgaac aattccccgc agcctcagaa tgtcgtgttt    480

gatgttcaga tccccaaagg agcattcatt tccaacttct ccatgactgt ggacggcaag    540

acatttagga gctctattaa ggagaaaact gtgggccgag ctctttatgc acaggccaga    600

gcaaaaggca agacggctgg cttggtgagg agcagcgctc ttgatatgga aaacttcaga    660

acggaagtaa atgtcctccc aggagcaaag gtgcagttcg aacttcacta ccaggaggtg    720

aagtggagga agctgggctc ctatgagcac aggatctatc tgcaacctgg acggctggcc    780

aaacacttag aggtagatgt gtgggttatc gaaccacagg gactgagatt tcttcatgtt    840

cccgacacat ttgaaggcca tttcgatggt gttccggtca tttctaaagg acaacagaag    900

gcgcacgtct ccttcaagcc cacggtagca cagcagagaa tatgccctaa ctgccgggag    960

actgcggtag atggggaact ggtggtgctg tatgacgtga aaagagaaga gaaggctggt   1020

gaactggagg tgtttaatgg atattttgtc cacttctttg ctcctgacaa cctggaccca   1080

attcccaaaa acatcctctt tgtcatcgat gtgagtggct ccatgtgggg agttaaaatg   1140

aaacaaactg tggaagcaat gaagaccata ttggatgacc tcagagcaga agaccatttc   1200

tctgtgattg atttcaacca gaacattcga acttggagaa atgatttaat ttcagctaca   1260

aaaacacagg ttgcagatgc caagaggtat attgagaaaa tccagcccag tggaggcaca   1320

aacatcaacg aagcactcct acgggcaatc ttcattttga atgaagccaa taacttggga   1380

ctgttagacc ccaactccgt ctcgctgatc attttggttt ctgatggaga tccaacagtg   1440

ggcgaactaa aactgtcaaa aattcagaaa aacgttaagg agaacatcca agacaatatc   1500

tccttgttca gtttgggcat gggatttgat gtggactatg attttttgaa gagactgtcc   1560

aatgaaaacc atggaattgc acaaaggatt tatggaaacc aggacacgtc ttcccagctt   1620

aagaaattct acaaccaggt ctccactcca ttgctccgga atgttcagtt caactatccc   1680

catacatcag tcacggacgt cactcaaaac aatttccata actactttgg aggctcagag   1740

attgtggtgg caggaaaatt tgaccctgct aaattggatc aaatagagag cgttatcacg   1800

gcgacttcgg ctaacacgca gttagtcttg gagaccctgg cccagatgga cgacttgcag   1860

gattttctat cgaaagacaa gcatgcagat cccgatttca ccaggaaact gtgggcctat   1920

ctaaccatca accaactgct agctgaacga agcctggctc ctacagctgc cgccaagaga   1980

agaattacaa gatcgatcct gcagatgtct ctagaccacc acattgtgac tccgctgacc   2040

tcgctggtga tcgagaacga ggctggggat gagcgcatgc tggcggatgc cccaccgcag   2100

gatccctcct gctgctcagg ggccctgtat tacggcagca aagtggttcc agattccacc   2160

ccgtcttggg ccaatccttc accaacgccc gtgatctcca tgctggcaca aggatctcag   2220

gtgctagagt ccacgccacc cccacatgtg atgagagttg aaaatgaccc acatttcatc   2280

atttatctac caaaaagcca aaagaacatt tgtttcaata ttgactcaga acctggaaaa   2340

atcctcaacc tggtttctga cccagaatca ggaattgtag tcaacggtca gcttgttggt   2400

gccaagaagc ccaacaatgg aaaactaagc acctattttg gaaaactggg attttatttc   2460

caaagtgaag acataaaaat agaaatcagc actgagacca tcaccctgag ccatggttct   2520

agcacattct ccttgtcctg gtccgacacg gctcaagtca cgaatcagag ggtgcagatc   2580

tcagtgaaga aagaaaaagt ggtaactatc accctggata aagagatgtc cttttctgtt   2640

ttacttcatc gtgtttggaa gaagcatccc gtcaatgttg actttctggg aatctacata   2700

ccccctacaa acaagttctc acctaaagcc cacggactaa taggccagtt catgcaggaa   2760

ccaaagatac acatcttcaa tgagagacca ggaaaggacc ctgagaagcc agaggccagc   2820

atggaagtga aggggcagaa gctgatcatc accaggggct tacagaaaga ctacagaacg   2880

gatctagtgt ttggaacgga cgttacctgc tggtttgtgc acaacagtgg aaaaggattc   2940

attgacgggc attacaagga ttacttcgtg cctcagctct acagctttct caaacggcct   3000

taaaggttta tagtttggga aattatatat attaatatac atctttcccc tgtcactttt   3060

gcagatattc ttcggtttga ataattaaaa tgaaccagat atcagggtgg ttaattaaaa   3120

tgaaccagat atcagggtgg tttataaagc ctgtaaacac acctaagaaa ataaacattt   3180

tacaaatgaa aaaaaaaa                                                 3198


<210>  2475
<211>  946
<212>  PRT
<213>  Homosapiens

<400>  2475

Met Lys Arg Leu Thr Cys Phe Phe Ile Cys Phe Phe Leu Ser Glu Val 
1               5                   10                  15      


Ser Gly Phe Glu Ile Pro Ile Asn Gly Leu Ser Glu Phe Val Asp Tyr 
            20                  25                  30          


Glu Asp Leu Val Glu Leu Ala Pro Gly Lys Phe Gln Leu Val Ala Glu 
        35                  40                  45              


Asn Arg Arg Tyr Gln Arg Ser Leu Pro Gly Glu Ser Glu Glu Met Met 
    50                  55                  60                  


Glu Glu Val Asp Gln Val Thr Leu Tyr Ser Tyr Lys Val Gln Ser Thr 
65                  70                  75                  80  


Ile Thr Ser Arg Met Ala Thr Thr Met Ile Gln Ser Lys Val Val Asn 
                85                  90                  95      


Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp Val Gln Ile Pro Lys 
            100                 105                 110         


Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val Asp Gly Lys Thr Phe 
        115                 120                 125             


Arg Ser Ser Ile Lys Glu Lys Thr Val Gly Arg Ala Leu Tyr Ala Gln 
    130                 135                 140                 


Ala Arg Ala Lys Gly Lys Thr Ala Gly Leu Val Arg Ser Ser Ala Leu 
145                 150                 155                 160 


Asp Met Glu Asn Phe Arg Thr Glu Val Asn Val Leu Pro Gly Ala Lys 
                165                 170                 175     


Val Gln Phe Glu Leu His Tyr Gln Glu Val Lys Trp Arg Lys Leu Gly 
            180                 185                 190         


Ser Tyr Glu His Arg Ile Tyr Leu Gln Pro Gly Arg Leu Ala Lys His 
        195                 200                 205             


Leu Glu Val Asp Val Trp Val Ile Glu Pro Gln Gly Leu Arg Phe Leu 
    210                 215                 220                 


His Val Pro Asp Thr Phe Glu Gly His Phe Asp Gly Val Pro Val Ile 
225                 230                 235                 240 


Ser Lys Gly Gln Gln Lys Ala His Val Ser Phe Lys Pro Thr Val Ala 
                245                 250                 255     


Gln Gln Arg Ile Cys Pro Asn Cys Arg Glu Thr Ala Val Asp Gly Glu 
            260                 265                 270         


Leu Val Val Leu Tyr Asp Val Lys Arg Glu Glu Lys Ala Gly Glu Leu 
        275                 280                 285             


Glu Val Phe Asn Gly Tyr Phe Val His Phe Phe Ala Pro Asp Asn Leu 
    290                 295                 300                 


Asp Pro Ile Pro Lys Asn Ile Leu Phe Val Ile Asp Val Ser Gly Ser 
305                 310                 315                 320 


Met Trp Gly Val Lys Met Lys Gln Thr Val Glu Ala Met Lys Thr Ile 
                325                 330                 335     


Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser Val Ile Asp Phe Asn 
            340                 345                 350         


Gln Asn Ile Arg Thr Trp Arg Asn Asp Leu Ile Ser Ala Thr Lys Thr 
        355                 360                 365             


Gln Val Ala Asp Ala Lys Arg Tyr Ile Glu Lys Ile Gln Pro Ser Gly 
    370                 375                 380                 


Gly Thr Asn Ile Asn Glu Ala Leu Leu Arg Ala Ile Phe Ile Leu Asn 
385                 390                 395                 400 


Glu Ala Asn Asn Leu Gly Leu Leu Asp Pro Asn Ser Val Ser Leu Ile 
                405                 410                 415     


Ile Leu Val Ser Asp Gly Asp Pro Thr Val Gly Glu Leu Lys Leu Ser 
            420                 425                 430         


Lys Ile Gln Lys Asn Val Lys Glu Asn Ile Gln Asp Asn Ile Ser Leu 
        435                 440                 445             


Phe Ser Leu Gly Met Gly Phe Asp Val Asp Tyr Asp Phe Leu Lys Arg 
    450                 455                 460                 


Leu Ser Asn Glu Asn His Gly Ile Ala Gln Arg Ile Tyr Gly Asn Gln 
465                 470                 475                 480 


Asp Thr Ser Ser Gln Leu Lys Lys Phe Tyr Asn Gln Val Ser Thr Pro 
                485                 490                 495     


Leu Leu Arg Asn Val Gln Phe Asn Tyr Pro His Thr Ser Val Thr Asp 
            500                 505                 510         


Val Thr Gln Asn Asn Phe His Asn Tyr Phe Gly Gly Ser Glu Ile Val 
        515                 520                 525             


Val Ala Gly Lys Phe Asp Pro Ala Lys Leu Asp Gln Ile Glu Ser Val 
    530                 535                 540                 


Ile Thr Ala Thr Ser Ala Asn Thr Gln Leu Val Leu Glu Thr Leu Ala 
545                 550                 555                 560 


Gln Met Asp Asp Leu Gln Asp Phe Leu Ser Lys Asp Lys His Ala Asp 
                565                 570                 575     


Pro Asp Phe Thr Arg Lys Leu Trp Ala Tyr Leu Thr Ile Asn Gln Leu 
            580                 585                 590         


Leu Ala Glu Arg Ser Leu Ala Pro Thr Ala Ala Ala Lys Arg Arg Ile 
        595                 600                 605             


Thr Arg Ser Ile Leu Gln Met Ser Leu Asp His His Ile Val Thr Pro 
    610                 615                 620                 


Leu Thr Ser Leu Val Ile Glu Asn Glu Ala Gly Asp Glu Arg Met Leu 
625                 630                 635                 640 


Ala Asp Ala Pro Pro Gln Asp Pro Ser Cys Cys Ser Gly Ala Leu Tyr 
                645                 650                 655     


Tyr Gly Ser Lys Val Val Pro Asp Ser Thr Pro Ser Trp Ala Asn Pro 
            660                 665                 670         


Ser Pro Thr Pro Val Ile Ser Met Leu Ala Gln Gly Ser Gln Val Leu 
        675                 680                 685             


Glu Ser Thr Pro Pro Pro His Val Met Arg Val Glu Asn Asp Pro His 
    690                 695                 700                 


Phe Ile Ile Tyr Leu Pro Lys Ser Gln Lys Asn Ile Cys Phe Asn Ile 
705                 710                 715                 720 


Asp Ser Glu Pro Gly Lys Ile Leu Asn Leu Val Ser Asp Pro Glu Ser 
                725                 730                 735     


Gly Ile Val Val Asn Gly Gln Leu Val Gly Ala Lys Lys Pro Asn Asn 
            740                 745                 750         


Gly Lys Leu Ser Thr Tyr Phe Gly Lys Leu Gly Phe Tyr Phe Gln Ser 
        755                 760                 765             


Glu Asp Ile Lys Ile Glu Ile Ser Thr Glu Thr Ile Thr Leu Ser His 
    770                 775                 780                 


Gly Ser Ser Thr Phe Ser Leu Ser Trp Ser Asp Thr Ala Gln Val Thr 
785                 790                 795                 800 


Asn Gln Arg Val Gln Ile Ser Val Lys Lys Glu Lys Val Val Thr Ile 
                805                 810                 815     


Thr Leu Asp Lys Glu Met Ser Phe Ser Val Leu Leu His Arg Val Trp 
            820                 825                 830         


Lys Lys His Pro Val Asn Val Asp Phe Leu Gly Ile Tyr Ile Pro Pro 
        835                 840                 845             


Thr Asn Lys Phe Ser Pro Lys Ala His Gly Leu Ile Gly Gln Phe Met 
    850                 855                 860                 


Gln Glu Pro Lys Ile His Ile Phe Asn Glu Arg Pro Gly Lys Asp Pro 
865                 870                 875                 880 


Glu Lys Pro Glu Ala Ser Met Glu Val Lys Gly Gln Lys Leu Ile Ile 
                885                 890                 895     


Thr Arg Gly Leu Gln Lys Asp Tyr Arg Thr Asp Leu Val Phe Gly Thr 
            900                 905                 910         


Asp Val Thr Cys Trp Phe Val His Asn Ser Gly Lys Gly Phe Ile Asp 
        915                 920                 925             


Gly His Tyr Lys Asp Tyr Phe Val Pro Gln Leu Tyr Ser Phe Leu Lys 
    930                 935                 940                 


Arg Pro 
945     


<210>  2476
<211>  1906
<212>  DNA
<213>  Homosapiens

<400>  2476
ggctggctga gtactggggt ccagaaagtg atcgctgccg tggtcgccat ggggaagtcg     60

gattttctta ctcccaaggc tatcgccaac aggatcaagt ccaaggggct gcagaagcta    120

cgctggtatt gccagatgtg ccagaagcag tgccgggacg agaatggctt taagtgtcat    180

tgtatgtccg aatctcatca gagacaacta ttgctggctt cagaaaatcc tcagcagttt    240

atggattatt tttcagagga attccgaaat gactttctag aacttctcag gagacgcttt    300

ggcactaaaa gggtccacaa caacattgtc tacaacgaat acatcagcca ccgagagcac    360

atccacatga atgccactca gtgggaaact ctgactgatt ttactaagtg gctgggcaga    420

gaaggcttgt gcaaagtgga cgagacacca aaaggctggt atattcagta catagacagg    480

gacccagaaa ctatccgccg gcaactggaa ctggagaaaa agaaaaagca ggaccttgat    540

gatgaagaaa aaactgccaa atttattgaa gagcaagtga gaagaggcct ggaagggaag    600

gaacaggagg tccctacttt tacggaatta agcagagaaa atgatgaaga gaaagtcacg    660

tttaatttga gtaaaggagc atgtagctca tccggagcaa catcttccaa gtcaagtact    720

ctgggaccga gtgcactgaa gacgatagga agttcagcat cagtgaaacg aaaagaatct    780

tcccagagct caactcagtc taaagaaaag aagaaaaaga aatctgcact ggatgaaatc    840

atggagattg aagaggaaaa gaaaagaact gcccgaacag actactggct acagcctgaa    900

attattgtga aaattataac caagaaactg ggagagaaat atcataagaa aaaggctatt    960

gttaaggaag taattgacaa atatacagct gttgtgaaga tgattgattc tggagacaag   1020

ctgaaacttg accagactca tttagagaca gtaattccag caccaggaaa aagaattcta   1080

gttttaaatg gaggctacag aggaaatgaa ggtaccctag aatccatcaa tgagaagact   1140

ttttcagcta ctatcgtcat tgaaactggc cctttaaaag gacgcagagt tgaaggaatt   1200

caatatgaag acatttctaa acttgcctga gtttgaaaat ttgttaacaa tacattaaaa   1260

tcttaaagca tcaaattggt gttcgccaag gcattatgag actctactgt gttagggtat   1320

attcttttgt ataaaacaaa caggtttttg aaaatattac tgtatagttg ttcagctaaa   1380

ctttgagaag aatttaatta tgtctcatga ggtatcaaac tatgtaattt tgtccttgtt   1440

atttttgttt cctttgtaat ttacttgatg agtttatatc ttcattaaag aatgttatta   1500

taaagtgttt tatctatgac aatttagaat catgtaattg gaggaaatcc ttcatacact   1560

ctatattttc agtagtagag tagtaaagtt gaactctaag tgtgactaaa ttttaaatgt   1620

caaactataa atatagaagc agctttattg tggtaataat tcatatacca tacagttcac   1680

tcatttaaaa tatacataca attcagtggt ttttagtatt tttgcagaat tgtgcagcca   1740

tcaccactgt ctgattttaa aacactttca taccccaaaa tgaaaccctt taatagtcaa   1800

tcgctatttt tcccctctgc cctagcccta gacagccact aatgtacttt ctgtctctat   1860

ggatttgccc tttctggaca tttcttataa atggaatcat ataata                  1906


<210>  2477
<211>  393
<212>  PRT
<213>  Homosapiens

<400>  2477

Met Gly Lys Ser Asp Phe Leu Thr Pro Lys Ala Ile Ala Asn Arg Ile 
1               5                   10                  15      


Lys Ser Lys Gly Leu Gln Lys Leu Arg Trp Tyr Cys Gln Met Cys Gln 
            20                  25                  30          


Lys Gln Cys Arg Asp Glu Asn Gly Phe Lys Cys His Cys Met Ser Glu 
        35                  40                  45              


Ser His Gln Arg Gln Leu Leu Leu Ala Ser Glu Asn Pro Gln Gln Phe 
    50                  55                  60                  


Met Asp Tyr Phe Ser Glu Glu Phe Arg Asn Asp Phe Leu Glu Leu Leu 
65                  70                  75                  80  


Arg Arg Arg Phe Gly Thr Lys Arg Val His Asn Asn Ile Val Tyr Asn 
                85                  90                  95      


Glu Tyr Ile Ser His Arg Glu His Ile His Met Asn Ala Thr Gln Trp 
            100                 105                 110         


Glu Thr Leu Thr Asp Phe Thr Lys Trp Leu Gly Arg Glu Gly Leu Cys 
        115                 120                 125             


Lys Val Asp Glu Thr Pro Lys Gly Trp Tyr Ile Gln Tyr Ile Asp Arg 
    130                 135                 140                 


Asp Pro Glu Thr Ile Arg Arg Gln Leu Glu Leu Glu Lys Lys Lys Lys 
145                 150                 155                 160 


Gln Asp Leu Asp Asp Glu Glu Lys Thr Ala Lys Phe Ile Glu Glu Gln 
                165                 170                 175     


Val Arg Arg Gly Leu Glu Gly Lys Glu Gln Glu Val Pro Thr Phe Thr 
            180                 185                 190         


Glu Leu Ser Arg Glu Asn Asp Glu Glu Lys Val Thr Phe Asn Leu Ser 
        195                 200                 205             


Lys Gly Ala Cys Ser Ser Ser Gly Ala Thr Ser Ser Lys Ser Ser Thr 
    210                 215                 220                 


Leu Gly Pro Ser Ala Leu Lys Thr Ile Gly Ser Ser Ala Ser Val Lys 
225                 230                 235                 240 


Arg Lys Glu Ser Ser Gln Ser Ser Thr Gln Ser Lys Glu Lys Lys Lys 
                245                 250                 255     


Lys Lys Ser Ala Leu Asp Glu Ile Met Glu Ile Glu Glu Glu Lys Lys 
            260                 265                 270         


Arg Thr Ala Arg Thr Asp Tyr Trp Leu Gln Pro Glu Ile Ile Val Lys 
        275                 280                 285             


Ile Ile Thr Lys Lys Leu Gly Glu Lys Tyr His Lys Lys Lys Ala Ile 
    290                 295                 300                 


Val Lys Glu Val Ile Asp Lys Tyr Thr Ala Val Val Lys Met Ile Asp 
305                 310                 315                 320 


Ser Gly Asp Lys Leu Lys Leu Asp Gln Thr His Leu Glu Thr Val Ile 
                325                 330                 335     


Pro Ala Pro Gly Lys Arg Ile Leu Val Leu Asn Gly Gly Tyr Arg Gly 
            340                 345                 350         


Asn Glu Gly Thr Leu Glu Ser Ile Asn Glu Lys Thr Phe Ser Ala Thr 
        355                 360                 365             


Ile Val Ile Glu Thr Gly Pro Leu Lys Gly Arg Arg Val Glu Gly Ile 
    370                 375                 380                 


Gln Tyr Glu Asp Ile Ser Lys Leu Ala 
385                 390             


<210>  2478
<211>  1162
<212>  DNA
<213>  Homosapiens

<400>  2478
gggaggggcg cgctggggag cttcggcgca tgcgcgctga ggcctgcctg accgaccttc     60

agcagggctg tggctaccat gttctctcgc gcgggtgtcg ctgggctgtc ggcctggacc    120

ttgcagccgc aatggattca agttcgaaat atggcaactt tgaaagatat caccaggaga    180

ctaaagtcca tcaaaaacat ccagaaaatt accaagtcta tgaaaatggt agcggcagca    240

aaatatgccc gagctgagag agagctgaaa ccagctcgaa tatatggatt gggatcttta    300

gctctgtatg aaaaagctga tatcaagggg cctgaagaca agaagaaaca cctccttatt    360

ggtgtgtcct cagatcgagg actgtgtggt gctattcatt cctccattgc taaacagatg    420

aaaagcgagg ttgctacact aacagcagct gggaaagaag ttatgcttgt tggaattggt    480

gacaaaatca gaggcatact ttataggact cattctgacc agtttctggt ggcattcaaa    540

gaagtgggaa gaaagccccc cacttttgga gatgcgtcag tcattgccct tgaattacta    600

aattctggat atgaatttga tgaaggctcc atcatcttta ataaattcag gtctgtcatc    660

tcctataaga cagaagaaaa gcccatcttt tcccttaata ccgttgcaag tgctgacagc    720

atgagtatct atgacgatat tgatgctgac gtgctgcaaa attaccaaga atacaatctg    780

gccaacatca tctactactc tctgaaggag tccaccacta gtgagcagag tgccaggatg    840

acagccatgg acaatgccag caagaatgct tctgagatga ttgacaaatt gacattgaca    900

ttcaaccgta cccgccaagc tgtcatcaca aaagagttga ttgaaattat ctctggtgct    960

gcagctctgg attaatgaaa atcaagttcc atcctcagac aagaggtaaa gaaggaaaat   1020

tcagccagtt gattttgttt ttagcttact gctgcctttg tccgaagaaa ctgttcctcc   1080

attatttgaa ttactgaaga cagcaagata tttgtaaatt atcttaaaat aaacaactta   1140

aaataaaaaa aaaaaaaaaa aa                                            1162


<210>  2479
<211>  298
<212>  PRT
<213>  Homosapiens

<400>  2479

Met Phe Ser Arg Ala Gly Val Ala Gly Leu Ser Ala Trp Thr Leu Gln 
1               5                   10                  15      


Pro Gln Trp Ile Gln Val Arg Asn Met Ala Thr Leu Lys Asp Ile Thr 
            20                  25                  30          


Arg Arg Leu Lys Ser Ile Lys Asn Ile Gln Lys Ile Thr Lys Ser Met 
        35                  40                  45              


Lys Met Val Ala Ala Ala Lys Tyr Ala Arg Ala Glu Arg Glu Leu Lys 
    50                  55                  60                  


Pro Ala Arg Ile Tyr Gly Leu Gly Ser Leu Ala Leu Tyr Glu Lys Ala 
65                  70                  75                  80  


Asp Ile Lys Gly Pro Glu Asp Lys Lys Lys His Leu Leu Ile Gly Val 
                85                  90                  95      


Ser Ser Asp Arg Gly Leu Cys Gly Ala Ile His Ser Ser Ile Ala Lys 
            100                 105                 110         


Gln Met Lys Ser Glu Val Ala Thr Leu Thr Ala Ala Gly Lys Glu Val 
        115                 120                 125             


Met Leu Val Gly Ile Gly Asp Lys Ile Arg Gly Ile Leu Tyr Arg Thr 
    130                 135                 140                 


His Ser Asp Gln Phe Leu Val Ala Phe Lys Glu Val Gly Arg Lys Pro 
145                 150                 155                 160 


Pro Thr Phe Gly Asp Ala Ser Val Ile Ala Leu Glu Leu Leu Asn Ser 
                165                 170                 175     


Gly Tyr Glu Phe Asp Glu Gly Ser Ile Ile Phe Asn Lys Phe Arg Ser 
            180                 185                 190         


Val Ile Ser Tyr Lys Thr Glu Glu Lys Pro Ile Phe Ser Leu Asn Thr 
        195                 200                 205             


Val Ala Ser Ala Asp Ser Met Ser Ile Tyr Asp Asp Ile Asp Ala Asp 
    210                 215                 220                 


Val Leu Gln Asn Tyr Gln Glu Tyr Asn Leu Ala Asn Ile Ile Tyr Tyr 
225                 230                 235                 240 


Ser Leu Lys Glu Ser Thr Thr Ser Glu Gln Ser Ala Arg Met Thr Ala 
                245                 250                 255     


Met Asp Asn Ala Ser Lys Asn Ala Ser Glu Met Ile Asp Lys Leu Thr 
            260                 265                 270         


Leu Thr Phe Asn Arg Thr Arg Gln Ala Val Ile Thr Lys Glu Leu Ile 
        275                 280                 285             


Glu Ile Ile Ser Gly Ala Ala Ala Leu Asp 
    290                 295             


<210>  2480
<211>  1125
<212>  DNA
<213>  Homosapiens

<400>  2480
gggaggggcg cgctggggag cttcggcgca tgcgcgctga ggcctgcctg accgaccttc     60

agcagggctg tggctaccat gttctctcgc gcgggtgtcg ctgggctgtc ggcctggacc    120

ttgcagccgc aatggattca agttcgaaat atggcaactt tgaaagatat caccaggaga    180

ctaaagtcca tcaaaaacat ccagaaaatt accaagtcta tgaaaatggt agcggcagca    240

aaatatgccc gagctgagag agagctgaaa ccagctcgaa tatatggatt gggatcttta    300

gctctgtatg aaaaagctga tatcaagggg cctgaagaca agaagaaaca cctccttatt    360

ggtgtgtcct cagatcgagg actgtgtggt gctattcatt cctccattgc taaacagatg    420

aaaagcgagg ttgctacact aacagcagct gggaaagaag ttatgcttgt tggaattggt    480

gacaaaatca gaggcatact ttataggact cattctgacc agtttctggt ggcattcaaa    540

gaagtgggaa gaaagccccc cacttttgga gatgcgtcag tcattgccct tgaattacta    600

aattctggat atgaatttga tgaaggctcc atcatcttta ataaattcag gtctgtcatc    660

tcctataaga cagaagaaaa gcccatcttt tcccttaata ccgttgcaag tgctgacagc    720

atgagtatct atgacgatat tgatgctgac gtgctgcaaa attaccaaga atacaatctg    780

gccaacatca tctactactc tctgaaggag tccaccacta gtgagcagag tgccaggatg    840

acagccatgg acaatgccag caagaatgct tctgagatga ttgacaaatt gacattgaca    900

ttcaaccgta cccgccaagc tgtcatcaca aaagagttga ttgaaattat ctctggtgct    960

gcagctctgt aaagaaggaa aattcagcca gttgattttg tttttagctt actgctgcct   1020

ttgtccgaag aaactgttcc tccattattt gaattactga agacagcaag atatttgtaa   1080

attatcttaa aataaacaac ttaaaataaa aaaaaaaaaa aaaaa                   1125


<210>  2481
<211>  297
<212>  PRT
<213>  Homosapiens

<400>  2481

Met Phe Ser Arg Ala Gly Val Ala Gly Leu Ser Ala Trp Thr Leu Gln 
1               5                   10                  15      


Pro Gln Trp Ile Gln Val Arg Asn Met Ala Thr Leu Lys Asp Ile Thr 
            20                  25                  30          


Arg Arg Leu Lys Ser Ile Lys Asn Ile Gln Lys Ile Thr Lys Ser Met 
        35                  40                  45              


Lys Met Val Ala Ala Ala Lys Tyr Ala Arg Ala Glu Arg Glu Leu Lys 
    50                  55                  60                  


Pro Ala Arg Ile Tyr Gly Leu Gly Ser Leu Ala Leu Tyr Glu Lys Ala 
65                  70                  75                  80  


Asp Ile Lys Gly Pro Glu Asp Lys Lys Lys His Leu Leu Ile Gly Val 
                85                  90                  95      


Ser Ser Asp Arg Gly Leu Cys Gly Ala Ile His Ser Ser Ile Ala Lys 
            100                 105                 110         


Gln Met Lys Ser Glu Val Ala Thr Leu Thr Ala Ala Gly Lys Glu Val 
        115                 120                 125             


Met Leu Val Gly Ile Gly Asp Lys Ile Arg Gly Ile Leu Tyr Arg Thr 
    130                 135                 140                 


His Ser Asp Gln Phe Leu Val Ala Phe Lys Glu Val Gly Arg Lys Pro 
145                 150                 155                 160 


Pro Thr Phe Gly Asp Ala Ser Val Ile Ala Leu Glu Leu Leu Asn Ser 
                165                 170                 175     


Gly Tyr Glu Phe Asp Glu Gly Ser Ile Ile Phe Asn Lys Phe Arg Ser 
            180                 185                 190         


Val Ile Ser Tyr Lys Thr Glu Glu Lys Pro Ile Phe Ser Leu Asn Thr 
        195                 200                 205             


Val Ala Ser Ala Asp Ser Met Ser Ile Tyr Asp Asp Ile Asp Ala Asp 
    210                 215                 220                 


Val Leu Gln Asn Tyr Gln Glu Tyr Asn Leu Ala Asn Ile Ile Tyr Tyr 
225                 230                 235                 240 


Ser Leu Lys Glu Ser Thr Thr Ser Glu Gln Ser Ala Arg Met Thr Ala 
                245                 250                 255     


Met Asp Asn Ala Ser Lys Asn Ala Ser Glu Met Ile Asp Lys Leu Thr 
            260                 265                 270         


Leu Thr Phe Asn Arg Thr Arg Gln Ala Val Ile Thr Lys Glu Leu Ile 
        275                 280                 285             


Glu Ile Ile Ser Gly Ala Ala Ala Leu 
    290                 295         


<210>  2482
<211>  7408
<212>  DNA
<213>  Homosapiens

<400>  2482
atgaatgatg gtgacacagt acaagaatac agtggccggc tggaaagggc tcccactggc     60

caaatacggg acaatttaag cagcaagaga atcacgaaga catactggga tgttggcaca    120

acccctacgc tggttctttg gcccatagtt ctgatggtac aaggacgagt tcagcagcca    180

cagtctgaaa agggcctgga aaccaggggc tcagacctgc acatgagggt ctgcatcatg    240

ccaccaaata agctactgag accagaagtg agagaaatgt ttgaaatttt ccgaaataaa    300

atcccctccc ctatacacag aaaggcaaat gaagaggaac aaacacccag ggtggcggcg    360

gtgagcgccc cagcacctgc cgccctgggc gcctcctcca cctgcgcgcc ccacgcccgc    420

ttccggccgg cttccaggcc tcagaggcga tcccgaggaa tcgttccgct cccaaggggc    480

ggagctttct catcgccgcg ctcggcattc ggcttatgct gcctcgcccc ggcggccgtc    540

cagcgggagg cggagcgagt ccaaaatggc ggctctcagg ctggcgcgct ccgtgctgct    600

ggggctttga ggtggtcgcc gggggtccgg gggacccttt ccccgccgcg gaagccctag    660

aggatgaatc ggggaccctg ctaaggtctg gcggcggggc tggagagcag tggcagcaag    720

ggctgcggtg gcgtccacgc agcgggatgt gcgagagtta ctccaggtcg ttgttgaggg    780

tctcggtggc gcagatctgc caggcgctgg gctgggactc ggtgcagctc agcgcctgcc    840

acctcctcac ggacgtgctg cagcgctatc tgcagcagct gggccggggc tgccatcggt    900

actctgagct ctatggccga acagacccaa ttttggatga tgttggtgaa gctttccagc    960

tgatgggggt tagtctacat gaactagaag actatattca caacattgag cctgtcacct   1020

tcccacacca aattccgtca tttcctgtta gcaagaacaa tgtacttcag tttcctcaac   1080

ctggaagtaa agatgcagag gaaagaaaag aatacattcc tgattacctg ccacccattg   1140

tgtcttctca agaagaagaa gaagaagagc aggtgcccac tgatggaggc acatcagcag   1200

aagccatgca ggttcccttg gaagaagatg atgaattgga ggaggaagaa attattaatg   1260

atgagaattt cctgggcaag agaccactgg atagtcctga agctgaagaa ctgccagcca   1320

tgaagcggcc tcggctatta agcactaaag gggacacgct agatgttgtg ttattggaag   1380

ctcgagagcc actcagctca ataaatactc aaaagatccc accaatgctt tctccagtcc   1440

atgtacagga cagtacagac ttggcacctc cctcacccga gccgccaatg ttggctccag   1500

ttgcaaaatc acaaatgcca actgcaaaac cattagaaac aaagtcattt acacctaaaa   1560

caaagactaa aactagctct ccaggacaga agactaaatc acctaaaacc gcccagtcac   1620

cagcaatggt cggaagtcct attcgatcac caaaaactgt atccaaagaa aagaaatcac   1680

ctggacgttc caagagcccc aagagtccca agagccccaa ggtcacgact cacattcccc   1740

aaacacctgt gagacctgaa acgcccaaca ggactccttc agctacactc agtgaaaaaa   1800

tcagtaaaga gactatccag gtaaaacaaa tacagacacc ccctgatgct gggaaactga   1860

acagtgagaa tcagccgaaa aaggctgtgg tagcagataa aacgattgag gcctctatcg   1920

atgctgtgat tgcacgagcc tgtgctgagc gagagccaga tcctttcgaa ttttcttctg   1980

gatcggaatc tgaaggagac atttttacta gccctaagag aatttcaggc ccggagtgta   2040

ctactcccaa agcttccact tccgcgaaca atttcacaaa gtcaggatcc actcctctgc   2100

ctctttccgg tggaacctca agttccgata actcatggac aatggatgcc tccattgatg   2160

aggttgtacg taaagcaaaa ctgggaacac cttcaaatat gccccccaac tttccttata   2220

tctcttctcc gtcagtgtct cctcccactc ccgaacctct ccacaaggtg tatgaggaga   2280

aaaccaagct gccttcctcc gtggaggtaa agaagaagtt gaaaaaggaa ctaaagacta   2340

aaatgaaaaa gaaagaaaag cagagagata gggagaggga aaaagacaag aacaaggaca   2400

aaagtaagga gaaggataaa gtgaaagaga aagagaaaga caaggaaact ggcagggaaa   2460

caaagtatcc ctggaaggaa tttcttaaag aggaagaggc agatccctac aagtttaaaa   2520

tcaaagaatt tgaagatgtt gatcccaaag tgaaattgaa agatggactt gtgaggaagg   2580

agaaagagaa gcataaagat aagaagaaag atagagagaa aggcaagaaa gataaagata   2640

agagagagaa agaaaaagtg aaagataaag gcagagaaga taagatgaaa gccccagcac   2700

ccccactggt gttgccccca aaagagttgg ccctgccctt gttcagccct gccacagcct   2760

ccagggtccc agccatgctg ccatctttgt tgccagtgct tccggaaaaa ctgtttgagg   2820

agaaagagaa ggtgaaggag aaagaaaaga aaaaggacaa aaaggagaag aagaaaaaga   2880

aggaaaaaga gaaggagaag aaggagaagg aaagagagaa agagaagaga gagcgagaga   2940

agagagaaaa agagaaggag aaacacaagc atgaaaaaat aaaagtggaa ccagtcgctc   3000

tggccccgag tccagttatc cccagattaa ctctccgagt cggtgctggc caagacaaga   3060

ttgtcatcag caaggtggtc cctgcccccg aggccaagcc ggcgccctcg cagaacaggc   3120

cgaagacccc accgccggcc cccgcgcccg cccccggccc catgctcgtc agccctgcgc   3180

ccgtgccgct gccgctgctc gcccaggccg ccgcgggccc tgccctgctg ccctccccgg   3240

gtcccgccgc ctccggggcc agtgccaaag cccccgtgcg cagcgtggtg actgagacgg   3300

tcagcaccta cgtgatccga gatgagtggg gcaatcagat ctggatctgc cctgggtgta   3360

acaagcctga cgatgggagt cccatgattg ggtgtgacga ctgcgatgac tggtaccact   3420

ggccctgtgt tggaatcatg actgcacccc cagaagagat gcagtggttc tgccccaagt   3480

gtgcgaacaa gaagaaggac aaaaagcaca agaagaggaa gcatcgagcc cactgacgac   3540

tcccgagggg ctggaccaag cggggtcagc ccgggcttct tccctggcgc ctctggaagg   3600

gagctggtgc aagtctgccg tcacatccac ccccagatgc ctgtggataa agaacccagg   3660

aggactgagg ctggaacaca ccgcgcacct ggattgttca ctcccgagcc gccttggcct   3720

gtggctccgt ggcagtgcga cagaaggaaa ctcaagcaga ggcgtggcct gggggctgcc   3780

cctcctccac ttctctaata ccagtgacaa gtattattaa taaagagcgt acatcttccc   3840

ttttgatttc ctttattctc tccagggcct tttcattgag gtattagatg agaagataat   3900

gtacaaactg cctcaactgt aatttaagga tgatagagtc tgtatacagt tttcagcccc   3960

tttccctcta tagtaagata atcagaataa cataaaagaa aactccagtt ggagtaccgg   4020

taaatatttt tgtgataaga atatatgaag cttccctcct tcccccgttt ttagtactaa   4080

catgtaaaat gttcaggctt ttgtgaaata ccttatattt tttaagaaaa aggtttctat   4140

catgtcctgt ttgcttttgt gcaaattatt tttgtttaat gtattttata tcttcgttgc   4200

attctaattt tgcccttctt taaactgctg gagtctcttc tcactgcttg tacatttcat   4260

caacttgtat aaaaactctt cagactaaaa gattgcccct aatgtaaata ataaatattt   4320

atgaagtagt tattttttaa atttttatcg tgtttaattc tggctttctc tgaaatccac   4380

tgtgatttca gccaggtctg taatgacgct ggacagaaac aaggctagag aaaaagccat   4440

cgttcaaaga aatttccctt gagctcagcc tgcgcagtgc ccggaaacat ggtggggaaa   4500

gggcccgagc agttggaagg aaaacaaggc aatttaaatt tagagtttat gacttgaagt   4560

tgttttgttt gttgtctatt ttgtttttgt aaatttcttt gacagacttt tactaaaagg   4620

acatgtagtt tccatgaaag taaaaaaaaa aaacaacaaa aaacccacat atactgtagc   4680

attttgtctt tatattgttt tatttctaca aatctgttca ttaatattgt gctttaaggc   4740

tgaaatgaag tatattatga atttttttaa gaaaactcat caaatttcag ggtatcacaa   4800

aactttatta tattattata ctgcccacta tttattatat gttatagatg tctgagaggt   4860

aaaccaaata ttttattttt aatgttaaaa aaacatcaaa tttaacttta ttagcatatt   4920

ttagcaactt tgggataaat acggactttt acttgatttt gaaataatcc cagtgtaggc   4980

ccatgtgctg gatctgttgg atgctagaat atgggctttg aacctaatac aaatatatta   5040

ctagaaaatg tgattttttt aaatgccaag taaattgata ttagtgtatg aattagtcat   5100

attttaaaac attatgtggt tagagaaatg cggttttctg ccatgaatgt taagttgcaa   5160

atcagtggaa atggagtcga cctcttcgga gcacagggtg tcattgccct cgttgttcaa   5220

gaggccagaa tttttctatc cccgctaaga aacaaagcat ctatgttgag atatgtgttt   5280

ttttgtttga ttaatttgag atcattctaa atactttata caatattttc acatgcacaa   5340

aaatgcgcgt tagtggtttt tggagagggg tgaggggtgg gggaagtgca aaataaagat   5400

tattggctat ttcatagttt gcttttccat tttctttatt taggatttag ttccttgagg   5460

cgtggtccat gatctgaagt tgccacgttt aagtgagcag gtcacgctac tgaaatcaga   5520

atggaggtgc ctatatataa ctttcccccc aatcttactg tctgagagac ttcagcccat   5580

gctacattta aggaatttca atcagtttgt tgtcccttgc tatttcatgg ttgctttcct   5640

aaatccagtt catgatttta taaatggtct ttgcaataat aaaaccaaag aatcattttc   5700

agggggctgg agagctcgag ggattagtaa tggaatacag agcctttcac ctctaggtca   5760

gtgagtcgga tccagtccag gtcactagag accaaaagtt gtcaccatct tatgactgtt   5820

cagtggcctg tgtgaaatga actggtggtc tcagtctcta ctgggtggct ggctgtgaca   5880

ccaaccaaag gaagttcaag aaactgcaaa gagaaatgtg gattagaaaa taaaacatcc   5940

acattacaaa gaaaaagtta gaaagttggg cgtagtcatt ctccagaaag taataccgaa   6000

gaaaaaagag caacttacaa ataccacaga caaacagaga ttaatttact ttccttaatg   6060

aagtcaagca aaaccggaaa agaaaagcct atattgggtg agaggggaga gggttaagtg   6120

gggaggatga tttgatcaga agaaaaagtt cagggaccca aacatcaggg aaaaatgggt   6180

tttgactttt gagggagaag gaaatcgcaa cagcagcaat ttgaggaact actgtagcag   6240

aattcgacac aaaggaatga gaagtatttc cctttagagg gcttgcagtg ttccagttgg   6300

aagcaaaacc ctgaccggct ttcatttagc ccagcactgt catttgaata gcatcaatac   6360

tttattaaga gaagtaatgc ggggggggcg gggattgtcc tgactagtga ttttattgag   6420

ggagatggta tttgagaaac agaccctcac ctcatgaaac cgagacgctc ttctggtgtg   6480

atgatctgcc gtcagagcca gatggaactg gcagagctta atttctgtgg ctgacaaggt   6540

gtttctcttc caaaggtgtc tacagtgagg cacagtgagg atctttatcc cctgactgat   6600

ttgtggttcc aaatgtcctg gagaaaacca gaggctatca gagtcttctg actttgtcgg   6660

gcttttttca gagataaaat atagtgcatt actctcctgt atcacctaaa ccgcctttgt   6720

tctcctttca atgggatgat taaacaaaga cctactaacc aaattaaagt ataaaatgaa   6780

cactgagata tggaaacctt gccactaaga atgctaatga aaaaagttca ctaaagccac   6840

gctggctatg ttttcaatac aaatagtttt atggccaatc tctttagatc atagcagttt   6900

tctttagaag tgtaagtcta aaagtagatg agttaccttg acggaagaat gaaacagata   6960

atgtcctgaa taatgtctct ttccacaatg gtatcagtca ttctgttagg aaactatttc   7020

tttgagaatc ttgcgttcgc tgcagcctaa aaagtataaa gtaactatta atccatgtgt   7080

gcaggcgagt agatgacatc gaaatgagat atttaggtgg acagcttgtt catttaatct   7140

acatatgagt tattaaaatg gctagtggtt atttttttcg ttctgggcaa ctcagtttta   7200

aatttagttt gaagaacatt gttacatggt ttcattcatt tcgtccacat ttgctacgca   7260

cgttttttgg aaatggcaat gatgtatcag aaccaagttc atttccagtt gcctggtttc   7320

tgagctgctc tagcccttcc gctggctcca tgattttgga attgttccca aagtatacta   7380

tgtattaaag tgtattgcat gaaattct                                      7408


<210>  2483
<211>  1178
<212>  PRT
<213>  Homosapiens


<220>
<221>  misc_feature
<222>  (220)..(220)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (228)..(228)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (259)..(259)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (321)..(321)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (329)..(329)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (441)..(441)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (447)..(447)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (454)..(454)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (468)..(468)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (512)..(512)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (584)..(584)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (608)..(608)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (620)..(620)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (631)..(631)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (643)..(643)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (770)..(770)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (774)..(774)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (778)..(778)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (782)..(782)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (808)..(808)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (851)..(851)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (853)..(853)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (858)..(858)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (887)..(887)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (896)..(896)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (945)..(945)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (994)..(994)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1010)..(1010)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1097)..(1097)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1105)..(1105)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1129)..(1129)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1147)..(1147)
<223>  Xaa can be any naturally occurring amino acid

<400>  2483

Met Asn Asp Gly Asp Thr Val Gln Glu Tyr Ser Gly Arg Leu Glu Arg 
1               5                   10                  15      


Ala Pro Thr Gly Gln Ile Arg Asp Asn Leu Ser Ser Lys Arg Ile Thr 
            20                  25                  30          


Lys Thr Tyr Trp Asp Val Gly Thr Thr Pro Thr Leu Val Leu Trp Pro 
        35                  40                  45              


Ile Val Leu Met Val Gln Gly Arg Val Gln Gln Pro Gln Ser Glu Lys 
    50                  55                  60                  


Gly Leu Glu Thr Arg Gly Ser Asp Leu His Met Arg Val Cys Ile Met 
65                  70                  75                  80  


Pro Pro Asn Lys Leu Leu Arg Pro Glu Val Arg Glu Met Phe Glu Ile 
                85                  90                  95      


Phe Arg Asn Lys Ile Pro Ser Pro Ile His Arg Lys Ala Asn Glu Glu 
            100                 105                 110         


Glu Gln Thr Pro Arg Val Ala Ala Val Ser Ala Pro Ala Pro Ala Ala 
        115                 120                 125             


Leu Gly Ala Ser Ser Thr Cys Ala Pro His Ala Arg Phe Arg Pro Ala 
    130                 135                 140                 


Ser Arg Pro Gln Arg Arg Ser Arg Gly Ile Val Pro Leu Pro Arg Gly 
145                 150                 155                 160 


Gly Ala Phe Ser Ser Pro Arg Ser Ala Phe Gly Leu Cys Cys Leu Ala 
                165                 170                 175     


Pro Ala Ala Val Gln Arg Glu Ala Glu Arg Val Gln Asn Gly Gly Ser 
            180                 185                 190         


Gln Ala Gly Ala Leu Arg Ala Ala Gly Ala Leu Arg Trp Ser Pro Gly 
        195                 200                 205             


Val Arg Gly Thr Leu Ser Pro Pro Arg Lys Pro Xaa Arg Met Asn Arg 
    210                 215                 220                 


Gly Pro Cys Xaa Gly Leu Ala Ala Gly Leu Glu Ser Ser Gly Ser Lys 
225                 230                 235                 240 


Gly Cys Gly Gly Val His Ala Ala Gly Cys Ala Arg Val Thr Pro Gly 
                245                 250                 255     


Arg Cys Xaa Gly Ser Arg Trp Arg Arg Ser Ala Arg Arg Trp Ala Gly 
            260                 265                 270         


Thr Arg Cys Ser Ser Ala Pro Ala Thr Ser Ser Arg Thr Cys Cys Ser 
        275                 280                 285             


Ala Ile Cys Ser Ser Trp Ala Gly Ala Ala Ile Gly Thr Leu Ser Ser 
    290                 295                 300                 


Met Ala Glu Gln Thr Gln Phe Trp Met Met Leu Val Lys Leu Ser Ser 
305                 310                 315                 320 


Xaa Trp Gly Leu Val Tyr Met Asn Xaa Lys Thr Ile Phe Thr Thr Leu 
                325                 330                 335     


Ser Leu Ser Pro Ser His Thr Lys Phe Arg His Phe Leu Leu Ala Arg 
            340                 345                 350         


Thr Met Tyr Phe Ser Phe Leu Asn Leu Glu Val Lys Met Gln Arg Lys 
        355                 360                 365             


Glu Lys Asn Thr Phe Leu Ile Thr Cys His Pro Leu Cys Leu Leu Lys 
    370                 375                 380                 


Lys Lys Lys Lys Lys Ser Arg Cys Pro Leu Met Glu Ala His Gln Gln 
385                 390                 395                 400 


Lys Pro Cys Arg Phe Pro Trp Lys Lys Met Met Asn Trp Arg Arg Lys 
                405                 410                 415     


Lys Leu Leu Met Met Arg Ile Ser Trp Ala Arg Asp His Trp Ile Val 
            420                 425                 430         


Leu Lys Leu Lys Asn Cys Gln Pro Xaa Ser Gly Leu Gly Tyr Xaa Ala 
        435                 440                 445             


Leu Lys Gly Thr Arg Xaa Met Leu Cys Tyr Trp Lys Leu Glu Ser His 
    450                 455                 460                 


Ser Ala Gln Xaa Ile Leu Lys Arg Ser His Gln Cys Phe Leu Gln Ser 
465                 470                 475                 480 


Met Tyr Arg Thr Val Gln Thr Trp His Leu Pro His Pro Ser Arg Gln 
                485                 490                 495     


Cys Trp Leu Gln Leu Gln Asn His Lys Cys Gln Leu Gln Asn His Xaa 
            500                 505                 510         


Lys Gln Ser His Leu His Leu Lys Gln Arg Leu Lys Leu Ala Leu Gln 
        515                 520                 525             


Asp Arg Arg Leu Asn His Leu Lys Pro Pro Ser His Gln Gln Trp Ser 
    530                 535                 540                 


Glu Val Leu Phe Asp His Gln Lys Leu Tyr Pro Lys Lys Arg Asn His 
545                 550                 555                 560 


Leu Asp Val Pro Arg Ala Pro Arg Val Pro Arg Ala Pro Arg Ser Arg 
                565                 570                 575     


Leu Thr Phe Pro Lys His Leu Xaa Asp Leu Lys Arg Pro Thr Gly Leu 
            580                 585                 590         


Leu Gln Leu His Ser Val Lys Lys Ser Val Lys Arg Leu Ser Arg Xaa 
        595                 600                 605             


Asn Lys Tyr Arg His Pro Leu Met Leu Gly Asn Xaa Thr Val Arg Ile 
    610                 615                 620                 


Ser Arg Lys Arg Leu Trp Xaa Gln Ile Lys Arg Leu Arg Pro Leu Ser 
625                 630                 635                 640 


Met Leu Xaa Leu His Glu Pro Val Leu Ser Glu Ser Gln Ile Leu Ser 
                645                 650                 655     


Asn Phe Leu Leu Asp Arg Asn Leu Lys Glu Thr Phe Leu Leu Ala Leu 
            660                 665                 670         


Arg Glu Phe Gln Ala Arg Ser Val Leu Leu Pro Lys Leu Pro Leu Pro 
        675                 680                 685             


Arg Thr Ile Ser Gln Ser Gln Asp Pro Leu Leu Cys Leu Phe Pro Val 
    690                 695                 700                 


Glu Pro Gln Val Pro Ile Thr His Gly Gln Trp Met Pro Pro Leu Met 
705                 710                 715                 720 


Arg Leu Tyr Val Lys Gln Asn Trp Glu His Leu Gln Ile Cys Pro Pro 
                725                 730                 735     


Thr Phe Leu Ile Ser Leu Leu Arg Gln Cys Leu Leu Pro Leu Pro Asn 
            740                 745                 750         


Leu Ser Thr Arg Cys Met Arg Arg Lys Pro Ser Cys Leu Pro Pro Trp 
        755                 760                 765             


Arg Xaa Arg Arg Ser Xaa Lys Arg Asn Xaa Arg Leu Lys Xaa Lys Arg 
    770                 775                 780                 


Lys Lys Ser Arg Glu Ile Gly Arg Gly Lys Lys Thr Arg Thr Arg Thr 
785                 790                 795                 800 


Lys Val Arg Arg Arg Ile Lys Xaa Lys Arg Lys Arg Lys Thr Arg Lys 
                805                 810                 815     


Leu Ala Gly Lys Gln Ser Ile Pro Gly Arg Asn Phe Leu Lys Arg Lys 
            820                 825                 830         


Arg Gln Ile Pro Thr Ser Leu Lys Ser Lys Asn Leu Lys Met Leu Ile 
        835                 840                 845             


Pro Lys Xaa Asn Xaa Lys Met Asp Leu Xaa Gly Arg Arg Lys Arg Ser 
    850                 855                 860                 


Ile Lys Ile Arg Arg Lys Ile Glu Arg Lys Ala Arg Lys Ile Lys Ile 
865                 870                 875                 880 


Arg Glu Arg Lys Lys Lys Xaa Lys Ile Lys Ala Glu Lys Ile Arg Xaa 
                885                 890                 895     


Lys Pro Gln His Pro His Trp Cys Cys Pro Gln Lys Ser Trp Pro Cys 
            900                 905                 910         


Pro Cys Ser Ala Leu Pro Gln Pro Pro Gly Ser Gln Pro Cys Cys His 
        915                 920                 925             


Leu Cys Cys Gln Cys Phe Arg Lys Asn Cys Leu Arg Arg Lys Arg Arg 
    930                 935                 940                 


Xaa Arg Arg Lys Lys Arg Lys Arg Thr Lys Arg Arg Arg Arg Lys Arg 
945                 950                 955                 960 


Arg Lys Lys Arg Arg Arg Arg Arg Arg Arg Lys Glu Arg Lys Arg Arg 
                965                 970                 975     


Glu Ser Glu Arg Arg Glu Lys Lys Arg Arg Arg Asn Thr Ser Met Lys 
            980                 985                 990         


Lys Xaa Lys Trp Asn Gln Ser Leu  Trp Pro Arg Val Gln  Leu Ser Pro 
        995                 1000                 1005             


Asp Xaa  Leu Ser Glu Ser Val  Leu Ala Lys Thr Arg  Leu Ser Ser 
    1010                 1015                 1020             


Ala Arg  Trp Ser Leu Pro Pro  Arg Pro Ser Arg Arg  Pro Arg Arg 
    1025                 1030                 1035             


Thr Gly  Arg Arg Pro His Arg  Arg Pro Pro Arg Pro  Pro Pro Ala 
    1040                 1045                 1050             


Pro Cys  Ser Ser Ala Leu Arg  Pro Cys Arg Cys Arg  Cys Ser Pro 
    1055                 1060                 1065             


Arg Pro  Pro Arg Ala Leu Pro  Cys Cys Pro Pro Arg  Val Pro Pro 
    1070                 1075                 1080             


Pro Pro  Gly Pro Val Pro Lys  Pro Pro Cys Ala Ala  Trp Xaa Leu 
    1085                 1090                 1095             


Arg Arg  Ser Ala Pro Thr Xaa  Ser Glu Met Ser Gly  Ala Ile Arg 
    1100                 1105                 1110             


Ser Gly  Ser Ala Leu Gly Val  Thr Ser Leu Thr Met  Gly Val Pro 
    1115                 1120                 1125             


Xaa Leu  Gly Val Thr Thr Ala  Met Thr Gly Thr Thr  Gly Pro Val 
    1130                 1135                 1140             


Leu Glu  Ser Xaa Leu His Pro  Gln Lys Arg Cys Ser  Gly Ser Ala 
    1145                 1150                 1155             


Pro Ser  Val Arg Thr Arg Arg  Arg Thr Lys Ser Thr  Arg Arg Gly 
    1160                 1165                 1170             


Ser Ile  Glu Pro Thr 
    1175             


<210>  2484
<211>  2232
<212>  DNA
<213>  Homosapiens

<400>  2484
ggaagaggaa caagtgtggg aaaagggaga ggaagccgga gctaaatgac aggatgcagg     60

cgacttgaga cacaaaaaga gaagcgttcc tctcggatcc aggcattgcc tcgctgcttt    120

cttttctcca agacgggctg aggattgtac agctctaggc ggagttgggg ctcttcggat    180

cgcttagatt ctcctctttg ctgcatttcc ccccacgtcc tcgttctccc gcgtctgcct    240

gcggacccgg agaagggaga atggagaggg ggctgccgct cctctgcgcc gtgctcgccc    300

tcgtcctcgc cccggccggc gcttttcgca acgataaatg tggcgatact ataaaaattg    360

aaagccccgg gtaccttaca tctcctggtt atcctcattc ttatcaccca agtgaaaaat    420

gcgaatggct gattcaggct ccggacccat accagagaat tatgatcaac ttcaaccctc    480

acttcgattt ggaggacaga gactgcaagt atgactacgt ggaagtcttc gatggagaaa    540

atgaaaatgg acattttagg ggaaagttct gtggaaagat agcccctcct cctgttgtgt    600

cttcagggcc atttcttttt atcaaatttg tctctgacta cgaaacacat ggtgcaggat    660

tttccatacg ttatgaaatt ttcaagagag gtcctgaatg ttcccagaac tacacaacac    720

ctagtggagt gataaagtcc cccggattcc ctgaaaaata tcccaacagc cttgaatgca    780

cttatattgt ctttgcgcca aagatgtcag agattatcct ggaatttgaa agctttgacc    840

tggagcctga ctcaaatcct ccagggggga tgttctgtcg ctacgaccgg ctagaaatct    900

gggatggatt ccctgatgtt ggccctcaca ttgggcgtta ctgtggacag aaaacaccag    960

gtcgaatccg atcctcatcg ggcattctct ccatggtttt ttacaccgac agcgcgatag   1020

caaaagaagg tttctcagca aactacagtg tcttgcagag cagtgtctca gaagatttca   1080

aatgtatgga agctctgggc atggaatcag gagaaattca ttctgaccag atcacagctt   1140

cttcccagta tagcaccaac tggtctgcag agcgctcccg cctgaactac cctgagaatg   1200

ggtggactcc cggagaggat tcctaccgag agtggataca ggtagacttg ggccttctgc   1260

gctttgtcac ggctgtcggg acacagggcg ccatttcaaa agaaaccaag aagaaatatt   1320

atgtcaagac ttacaagatc gacgttagct ccaacgggga agactggatc accataaaag   1380

aaggaaacaa acctgttctc tttcagggaa acaccaaccc cacagatgtt gtggttgcag   1440

tattccccaa accactgata actcgatttg tccgaatcaa gcctgcaact tgggaaactg   1500

gcatatctat gagatttgaa gtatacggtt gcaagataac agattatcct tgctctggaa   1560

tgttgggtat ggtgtctgga cttatttctg actcccagat cacatcatcc aaccaagggg   1620

acagaaactg gatgcctgaa aacatccgcc tggtaaccag tcgctctggc tgggcacttc   1680

cacccgcacc tcattcctac atcaatgagt ggctccaaat agacctgggg gaggagaaga   1740

tcgtgagggg catcatcatt cagggtggga agcaccgaga gaacaaggtg ttcatgagga   1800

agttcaagat cgggtacagc aacaacggct cggactggaa gatgatcatg gatgacagca   1860

aacgcaaggc gaagtctttt gagggcaaca acaactatga tacacctgag ctgcggactt   1920

ttccagctct ctccacgcga ttcatcagga tctaccccga gagagccact catggcggac   1980

tggggctcag aatggagctg ctgggctgtg aagtggaagc ccctacagct ggaccgacca   2040

ctcccaacgg gaacttggtg gatgaatgtg atgacgacca ggccaactgc cacagtggaa   2100

caggtgatga cttccagctc acaggtggca ccactgtgct ggccacagaa aagcccacgg   2160

tcatagacag caccatacaa tcaggtatca aataaaatac gaaatgtgac aaaaaaaaaa   2220

aaaaaaaaaa aa                                                       2232


<210>  2485
<211>  644
<212>  PRT
<213>  Homosapiens

<400>  2485

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Gly Ile Lys 
                


<210>  2486
<211>  2005
<212>  DNA
<213>  Homosapiens

<400>  2486
cttttcacca agacgggctg aggattgtac agctctaggc ggagttgggg ctcttcggat     60

cgcttagatt ctcctctttg ctgcatttcc ccccacgtcc tcgttctccc gcgtctgcct    120

gcggacccgg agaagggaga atggagaggg ggctgccgct cctctgcgcc gtgctcgccc    180

tcgtcctcgc cccggccggc gcttttcgca acgataaatg tggcgatact ataaaaattg    240

aaagccccgg gtaccttaca tctcctggtt atcctcattc ttatcaccca agtgaaaaat    300

gcgaatggct gattcaggct ccggacccat accagagaat tatgatcaac ttcaaccctc    360

acttcgattt ggaggacaga gactgcaagt atgactacgt ggaagtcttc gatggagaaa    420

atgaaaatgg acattttagg ggaaagttct gtggaaagat agcccctcct cctgttgtgt    480

cttcagggcc atttcttttt atcaaatttg tctctgacta cgaaacacat ggtgcaggat    540

tttccatacg ttatgaaatt ttcaagagag gtcctgaatg ttcccagaac tacacaacac    600

ctagtggagt gataaagtcc cccggattcc ctgaaaaata tcccaacagc cttgaatgca    660

cttatattgt ctttgcgcca aagatgtcag agattatcct ggaatttgaa agctttgacc    720

tggagcctga ctcaaatcct ccagggggga tgttctgtcg ctacgaccgg ctagaaatct    780

gggatggatt ccctgatgtt ggccctcaca ttgggcgtta ctgtggacag aaaacaccag    840

gtcgaatccg atcctcatcg ggcattctct ccatggtttt ttacaccgac agcgcgatag    900

caaaagaagg tttctcagca aactacagtg tcttgcagag cagtgtctca gaagatttca    960

aatgtatgga agctctgggc atggaatcag gagaaattca ttctgaccag atcacagctt   1020

cttcccagta tagcaccaac tggtctgcag agcgctcccg cctgaactac cctgagaatg   1080

ggtggactcc cggagaggat tcctaccgag agtggataca ggtagacttg ggccttctgc   1140

gctttgtcac ggctgtcggg acacagggcg ccatttcaaa agaaaccaag aagaaatatt   1200

atgtcaagac ttacaagatc gacgttagct ccaacgggga agactggatc accataaaag   1260

aaggaaacaa acctgttctc tttcagggaa acaccaaccc cacagatgtt gtggttgcag   1320

tattccccaa accactgata actcgatttg tccgaatcaa gcctgcaact tgggaaactg   1380

gcatatctat gagatttgaa gtatacggtt gcaagataac agattatcct tgctctggaa   1440

tgttgggtat ggtgtctgga cttatttctg actcccagat cacatcatcc aaccaagggg   1500

acagaaactg gatgcctgaa aacatccgcc tggtaaccag tcgctctggc tgggcacttc   1560

cacccgcacc tcattcctac atcaatgagt ggctccaaat agacctgggg gaggagaaga   1620

tcgtgagggg catcatcatt cagggtggga agcaccgaga gaacaaggtg ttcatgagga   1680

agttcaagat cgggtacagc aacaacggct cggactggaa gatgatcatg gatgacagca   1740

aacgcaaggc gaagtctttt gagggcaaca acaactatga tacacctgag ctgcggactt   1800

ttccagctct ctccacgcga ttcatcagga tctaccccga gagagccact catggcggac   1860

tggggctcag aatggagctg ctgggctgtg aagtggaagg tggcaccact gtgctggcca   1920

cagaaaagcc cacggtcata gacagcacca tacaatcagg tatcaaataa aatacgaaat   1980

gtgacagaaa aaaaaaaaaa aaaaa                                         2005


<210>  2487
<211>  609
<212>  PRT
<213>  Homosapiens

<400>  2487

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Gly Gly Thr Thr Val Leu 
            580                 585                 590         


Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Gly Ile 
        595                 600                 605             


Lys 
    


<210>  2488
<211>  5890
<212>  DNA
<213>  Homosapiens

<400>  2488
ggcagttggt gaaactcctc tgtctcccgc tcatcttttc attgctcgtt cccctccttc     60

ccgcagacac ccggacctcc cctgggcgcc agctccgcgg ctccaacggg tccagaaaca    120

agccggattt tttttttttt tcttcctgga aattggcttt ggtgtgtgtt gccctacctc    180

cctcctcccc ctcccaccca cagccccccc ccggcctttt tttttttttt ttttttttga    240

gacatggccc gggcagtggc tcctggaaga ggaacaagtg tgggaaaagg gagaggaagc    300

cggagctaaa tgacaggatg caggcgactt gagacacaaa aagagaagcg ttcctctcgg    360

atccaggcat tgcctcgctg ctttcttttc tccaagacgg gctgaggatt gtacagctct    420

aggcggagtt ggggctcttc ggatcgctta gattctcctc tttgctgcat ttccccccac    480

gtcctcgttc tcccgcgtct gcctgcggac ccggagaagg gagaatggag agggggctgc    540

cgctcctctg cgccgtgctc gccctcgtcc tcgccccggc cggcgctttt cgcaacgata    600

aatgtggcga tactataaaa attgaaagcc ccgggtacct tacatctcct ggttatcctc    660

attcttatca cccaagtgaa aaatgcgaat ggctgattca ggctccggac ccataccaga    720

gaattatgat caacttcaac cctcacttcg atttggagga cagagactgc aagtatgact    780

acgtggaagt cttcgatgga gaaaatgaaa atggacattt taggggaaag ttctgtggaa    840

agatagcccc tcctcctgtt gtgtcttcag ggccatttct ttttatcaaa tttgtctctg    900

actacgaaac acatggtgca ggattttcca tacgttatga agttttcaag agaggtcctg    960

aatgttccca gaactacaca acacctagtg gagtgataaa gtcccccgga ttccctgaaa   1020

aatatcccaa cagccttgaa tgcacttata ttgtctttgc gccaaagatg tcagagatta   1080

tcctggaatt tgaaagcttt gacctggagc ctgactcaaa tcctccaggg gggatgttct   1140

gtcgctacga ccggctagaa atctgggatg gattccctga tgttggccct cacattgggc   1200

gttactgtgg acagaaaaca ccaggtcgaa tccgatcctc atcgggcatt ctctccatgg   1260

ttttttacac cgacagcgcg atagcaaaag aaggtttctc agcaaactac agtgtcttgc   1320

agagcagtgt ctcagaagat ttcaaatgta tggaagctct gggcatggaa tcaggagaaa   1380

ttcattctga ccagatcaca gcttcttccc agtatagcac caactggtct gcagagcgct   1440

cccgcctgaa ctaccctgag aatgggtgga ctcccggaga ggattcctac cgagagtgga   1500

tacaggtaga cttgggcctt ctgcgctttg tcacggctgt cgggacacag ggcgccattt   1560

caaaagaaac caagaagaaa tattatgtca agacttacaa gatcgacgtt agctccaacg   1620

gggaagactg gatcaccata aaagaaggaa acaaacctgt tctctttcag ggaaacacca   1680

accccacaga tgttgtggtt gcagtattcc ccaaaccact gataactcga tttgtccgaa   1740

tcaagcctgc aacttgggaa actggcatat ctatgagatt tgaagtatac ggttgcaaga   1800

taacagatta tcctcgctct ggaatgttgg gtatggtgtc tggacttatt tctgactccc   1860

agatcacatc atccaaccaa ggggacagaa actggatgcc tgaaaacatc cgcctggtaa   1920

ccagtcgctc tggctgggca cttccacccg cacctcattc ctacatcaat gagtggctcc   1980

aaatagacct gggggaggag aagatcgtga ggggcatcat cattcagggt gggaagcacc   2040

gagagaacaa ggtgttcatg aggaagttca agatcgggta cagcaacaac ggctcggact   2100

ggaagatgat catggatgac agcaaacgca aggcgaagtc ttttgagggc aacaacaact   2160

atgatacacc tgagctgcgg acttttccag ctctctccac gcgattcatc aggatctacc   2220

ccgagagagc cactcatggc ggactggggc tcagaatgga gctgctgggc tgtgaagtgg   2280

aagcccctac agctggaccg accactccca acgggaactt ggtggatgaa tgtgatgacg   2340

accaggccaa ctgccacagt ggaacaggtg atgacttcca gctcgcaggt ggcaccactg   2400

tgctggccac agaaaagccc acggtcatag acagcaccat acaatcagag tttccaacat   2460

atggttttaa ctgtgaattt ggctggggct ctcacaagac cttctgccac tgggaacatg   2520

acaatcacgt gcagctcaag tggagtgtgt tgaccagcaa gacgggaccc attcaggatc   2580

acacaggaga tggcaacttc atctattccc aagctgacga aaatcagaag ggcaaagtgg   2640

ctcgcctggt gagccctgtg gtttattccc agaactctgc ccactgcatg accttctggt   2700

atcacatgtc tgggtcccac gtcggcacac tcagggtcaa actgcgctac cagaagccag   2760

aggagtacga tcagctggtc tggatggcca ttggacacca aggtgaccac tggaaggaag   2820

ggcgtgtctt gctccacaag tctctgaaac tttatcaggt gattttcgag ggcgaaatcg   2880

gaaaaggaaa ccttggtggg attgctgtgg atgacattag tattaataac cacatttcac   2940

aagaagattg tgcaaaacca gcagacctgg ataaaaagaa cccagaaatt aaaattgatg   3000

aaacagggag cgcgccagga tacgaaggtg aaggagaagg tgacaagaac atctccagga   3060

agccaggcaa tgtgttgaag accttagacc ccatcctcat caccatcata gccatgagtg   3120

ccctgggggt cctcctgggg gctgtctgtg gggtcgtgct gtactgtgcc tgttggcata   3180

atgggatgtc agaaagaaac ttgtctgccc tggagaacta taactttgaa cttgtggatg   3240

gtgtgaagtt gaaaaaagac aaactgaata cacagagtac ttattcggag gcatgaaggc   3300

agacagagat gaaaagacag tcaaaggacg gaagtggaag gacgggagtg agctggggag   3360

ctgttgatct ttcactatac aggctgggaa gtgtgttgat gaccactgag ccaggctttt   3420

ctcaggagct tcaatgagta tggccgacag acatggacaa ggagctgtgt tcaccatcgg   3480

actcatgtgc agtcagcttt tttcctgttg gtttcatttg aataatcaga tgctggtgtt   3540

gagaccaagt atgattgaca taatcattca tttcgacccc tcctgcccct ctctctctct   3600

ctcctctccc ctttgtggat tctttttgga aactgagcga aatccaagat gctggcacca   3660

agcgtattcc gtgtggccct ttggatggac atgctacctg aaacccagtg cccagaatat   3720

actagaatca ccgcatttca gtggactcct gaagttgtac ttgtgtataa ttgcccgcgt   3780

cgtgcatagg caaagaagga ttaggctgtt ttctttttaa agtactgtag cctcagtact   3840

ggtgtagtgt gtcagctctg tttacgaagc aatactgtcc agttttcttg ctgtttttcc   3900

ggtgttgtac taaacctcgt gcttgtgaac tccatacaga aaacggtgcc atccctgaac   3960

acggctggcc actgggtata ctgctgacaa ccgcaacaac aaaaacacaa atccttggca   4020

ctggctagtc tatgtcctct caagtgcctt tttgtttgta ctggttcatt gtgttacatt   4080

aacgacccac tctgcttctt gctggtgaaa gccctgctct ttaatcaaac tctggtggcc   4140

cactgactaa gaagaaagtt tattttcgtg tgagatgcca gcccctccgg gcaggcaagg   4200

gctctgaaga tttggcaacg tggcttaatt gttctgcttt ttctgtagtt caatttcatg   4260

tttcttgacc cttttgtata aagctacaat attctctctt attgttcttt catatggaat   4320

gtattttcaa atgtaaactc tcttctcttt ctctctccta tctctctgtc ttttttctct   4380

cttagaattg gaggatttgc cattgtccag gaaagaaact tgcagcttta acctgctggg   4440

aatggcaaac gattttacta gactttatgt ttaaaaataa ataaataagg gaaattccta   4500

actttgccct ccaaagtcta actttggttt tcttgttaac tggttaaagt gacagtatct   4560

tttttcctta tctattctat tcaaaatgac ctttgataga aatgttggca tttagtagaa   4620

atagtgataa gttgaggaaa gaaataatac aaattggctt tcaagtgaga cccaaaggaa   4680

gaactggata aaatcttcca aatccaaaag catgagattt ttctatccaa atatgcaaaa   4740

atgacccaag agaactttct tattttgcta ctgagtcaca caagggaagt ggaaggaaga   4800

acagttaatt taagaatgaa actataaatc ctgatgcctg ggggtcaagt attttaagat   4860

aagaggggga aaaacacata gagtcaaaca aatgttttaa aaattcataa cagcaacctt   4920

gaaaaaatag acttaaatga atgcttctag aaacttccag cggctcacaa agaataagcc   4980

tgccttaggg ctggcaacat ctaagcctct aacagcacag ggaagcaaat atcttaccag   5040

gcagcctatg aattaaccca aagaagcttt ggttggtttt ggtggatttt tatcatgcca   5100

tgttggacat gagatttttt agatcttcct tcccacattg ctagacgtct cactcaaaga   5160

catttgttgg gagtcacatt tgcatcatag acgagacagt ccattcatct tagttaaatt   5220

ggattgagaa tgccttttgt ttccaggaaa atattgatca ccatgaaaga agaatagttt   5280

tttgtcccca gagacattca tttagttgat ataatcctac cagaaggaaa gcactaagaa   5340

acactcgttt gttgttttta aaggcaacag acttaaagtt gtcctcagcc aaggaaaaat   5400

gatactgcaa ctttaaaatt taaagtatct tgcactgata aatatattta aaaattatat   5460

gtctataaag ttattaattt gtaaaggcag tgttacaaaa tgttcagttt atattgtttt   5520

agattgtttt gtaattttta aaggtgtaaa ataacatatt ttttctttat ggaaatctat   5580

aaaactttct gtagtaaaat gttttcattt tactggtata ttattgcttc atgttttgta   5640

ccatcataag attttgtgca gattttttta cagaaattat tattttctat gacaatatga   5700

cacttgtaaa ttgttgtttc aaaatgaaca gcgaagcctt aactttaaat gacatttgta   5760

ttctcagaca ctgagtagca taaaaaccac atagaactga actgtaactt aaattccaaa   5820

ctatgactac tacattccaa agaaacagtt gaattaaaca ttttcataaa ataaaaaaaa   5880

aaaaaaaaaa                                                          5890


<210>  2489
<211>  923
<212>  PRT
<213>  Homosapiens

<400>  2489

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Val Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Arg Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Ala Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Ala Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  2490
<211>  1546
<212>  DNA
<213>  Homosapiens

<400>  2490
gattgtggga aggcagctga actcggcgcc tggaaagatg gaggcagcgg agacagaggc     60

ggaagctgca gccctagagg tcctggctga ggtggcaggc atcttggaac ctgtaggcct    120

gcaggaggag gcagaactgc cagccaagat cctggttgag tttgtggtgg actctcagaa    180

gaaagacaag ctgctctgca gccagcttca ggtagcggat ttcctgcaga acatcctggc    240

tcaggaggac actgctaagg gtctcgaccc cttggcttct gaagacacga gccgacagaa    300

ggcaattgca gctaaggaac aatggaaaga gctgaaggcc acctacaggg agcacgtaga    360

ggccatcaaa attggcctca ccaaggccct gactcagatg gaggaagccc agaggaaacg    420

gacacaactc cgggaagcct ttgagcagct ccaggccaag aaacaaatgg ccatggagaa    480

acgcagagca gtccagaacc agtggcagct acaacaggag aagcatctgc agcatctggc    540

ggaggtttct gcagagggta agctgttgtt ccctgaggct gaggctgagg cagagaatct    600

tccagatgat aaaccccagc agccgactcg accccaggag cagagtacag gagacaccat    660

ggggagagac cctggtgtgt ccttcaaggc tgttggtcta caacctgctg gagatgtaaa    720

tttgccatga cttcctggag gacagcagca tggagaaaga tcctagaaaa ggcctctgac    780

ttccctcacc tcccaaccat cattacagga aagactgtga actcctgagt tcagcttgat    840

ttctgactac atcccagcaa gctctggcat ctgtggatta aaatccctgg atctctctca    900

gttgtgtatt tgttcatctt catatgctgg caggaacaac tattaataca gatactcaga    960

agccaataac atgacaggag ctgggactgg tttgaacaca gggtgtgcag atggggaggg   1020

ggtactggcc ttgggcctcc tatgatgcag acatggtgaa tttaattcaa ggaggaggag   1080

aatgttttag gcaggtggtt atatgtggga agataatttt attcatggat ccaaatgttt   1140

gttgagtcct ttctttgtgc taaggttctt gcggtgaacc agaattataa cagtgagctc   1200

atctgactgt tttaggatgt acagcctagt gttaacattc ttggtatctt tttgtgcctt   1260

atctaaaaca tttctcgatc actggtttca gatgttcatt tattatattc ttttcaaaga   1320

ttcagagatt ggcttttgtc atccactatt gtatgttttg tttcattgac ctctagtgat   1380

accttgatct ttcccacttt ctgttttcgg attggagaag atgtaccttt tttgtcaact   1440

cttactttta tcagatgatc aactcacgta tttggatctt tatttgtttt ctcaaataaa   1500

tatttaaggt tatacattta aaaaaaaaaa aaaaaaaaaa aaaaaa                  1546


<210>  2491
<211>  230
<212>  PRT
<213>  Homosapiens

<400>  2491

Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu 
1               5                   10                  15      


Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala 
            20                  25                  30          


Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys 
        35                  40                  45              


Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln 
    50                  55                  60                  


Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala 
65                  70                  75                  80  


Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp 
                85                  90                  95      


Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile 
            100                 105                 110         


Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg 
        115                 120                 125             


Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met 
    130                 135                 140                 


Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln 
145                 150                 155                 160 


Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Gly Lys Leu 
                165                 170                 175     


Leu Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys 
            180                 185                 190         


Pro Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met 
        195                 200                 205             


Gly Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala 
    210                 215                 220                 


Gly Asp Val Asn Leu Pro 
225                 230 


<210>  2492
<211>  2002
<212>  DNA
<213>  Homosapiens

<400>  2492
gattgtggga aggcagctga actcggcgcc tggaaagatg gaggcagcgg agacagaggc     60

ggaagctgca gccctagagg tcctggctga ggtggcaggc atcttggaac ctgtaggcct    120

gcaggaggag gcagaactgc cagccaagat cctggttgag tttgtggtgg tatgtacaag    180

atgagagcga gcctttcaga agccagggtc tggtcctggc tcctcttact gagatacagg    240

gcagcattgg cagagagcag acttaaggaa acctgtaagg aggtaaggat gttccctgtc    300

tctgccctcc ctctgagcag gactctcaga agaaagacaa gctgctctgc agccagcttc    360

aggtagcgga tttcctgcag aacatcctgg ctcaggagga cactgctaag ggtctcgacc    420

ccttggcttc tgaagacacg agccgtgagt aggcagggga ttgtagtagc agctgacctg    480

agtggggaag gaaggaggat ttcagttagg tctcccattt ggctgatggg aaggaggccc    540

agtgttgcag ggaggcaggc tagcaggcca ccctcactca tgtactcatt cctggtggct    600

catctcagga cagaaggcaa ttgcagctaa ggaacaatgg aaagagctga aggccaccta    660

cagggagcac gtagaggcca tcaaaattgg cctcaccaag gccctgactc agatggagga    720

agcccagagg aaacggacac aactccggga agcctttgag cagctccagg ccaagaaaca    780

aatggccatg gagaaacgca gagcagtcca gaaccagtgg cagctacaac aggagaagca    840

tctgcagcat ctggcggagg tttctgcaga ggtgagggag cgtaagacag ggactcagca    900

ggagcttgac agggtgtttc agaaacttgg aaacctgaag cagcaggcag aacaggagcg    960

ggacaagctg cagaggtatc agaccttcct ccagcttctg tataccctgc agggtaagct   1020

gttgttccct gaggctgagg ctgaggcaga gaatcttcca gatgataaac cccagcagcc   1080

gactcgaccc caggagcaga gtacaggaga caccatgggg agagaccctg gtgtgtcctt   1140

caaggctgtt ggtctacaac ctgctggaga tgtaaatttg ccatgacttc ctggaggaca   1200

gcagcatgga gaaagatcct agaaaaggcc tctgacttcc ctcacctccc aaccatcatt   1260

acaggaaaga ctgtgaactc ctgagttcag cttgatttct gactacatcc cagcaagctc   1320

tggcatctgt ggattaaaat ccctggatct ctctcagttg tgtatttgtt catcttcata   1380

tgctggcagg aacaactatt aatacagata ctcagaagcc aataacatga caggagctgg   1440

gactggtttg aacacagggt gtgcagatgg ggagggggta ctggccttgg gcctcctatg   1500

atgcagacat ggtgaattta attcaaggag gaggagaatg ttttaggcag gtggttatat   1560

gtgggaagat aattttattc atggatccaa atgtttgttg agtcctttct ttgtgctaag   1620

gttcttgcgg tgaaccagaa ttataacagt gagctcatct gactgtttta ggatgtacag   1680

cctagtgtta acattcttgg tatctttttg tgccttatct aaaacatttc tcgatcactg   1740

gtttcagatg ttcatttatt atattctttt caaagattca gagattggct tttgtcatcc   1800

actattgtat gttttgtttc attgacctct agtgatacct tgatctttcc cactttctgt   1860

tttcggattg gagaagatgt accttttttg tcaactctta cttttatcag atgatcaact   1920

cacgtatttg gatctttatt tgttttctca aataaatatt taaggttata catttaaaaa   1980

aaaaaaaaaa aaaaaaaaaa aa                                            2002


<210>  2493
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  2493

Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu 
1               5                   10                  15      


Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala 
            20                  25                  30          


Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Val Cys Thr Arg 
        35                  40                  45              


<210>  2494
<211>  1687
<212>  DNA
<213>  Homosapiens

<400>  2494
gattgtggga aggcagctga actcggcgcc tggaaagatg gaggcagcgg agacagaggc     60

ggaagctgca gccctagagg tcctggctga ggtggcaggc atcttggaac ctgtaggcct    120

gcaggaggag gcagaactgc cagccaagat cctggttgag tttgtggtgg actctcagaa    180

gaaagacaag ctgctctgca gccagcttca ggtagcggat ttcctgcaga acatcctggc    240

tcaggaggac actgctaagg gtctcgaccc cttggcttct gaagacacga gccgacagaa    300

ggcaattgca gctaaggaac aatggaaaga gctgaaggcc acctacaggg agcacgtaga    360

ggccatcaaa attggcctca ccaaggccct gactcagatg gaggaagccc agaggaaacg    420

gacacaactc cgggaagcct ttgagcagct ccaggccaag aaacaaatgg ccatggagaa    480

acgcagagca gtccagaacc agtggcagct acaacaggag aagcatctgc agcatctggc    540

ggaggtttct gcagaggtga gggagcgtaa gacagggact cagcaggagc ttgacagggt    600

gtttcagaaa cttggaaacc tgaagcagca ggcagaacag gagcgggaca agctgcagag    660

gtatcagacc ttcctccagc ttctgtatac cctgcagggt aagctgttgt tccctgaggc    720

tgaggctgag gcagagaatc ttccagatga taaaccccag cagccgactc gaccccagga    780

gcagagtaca ggagacacca tggggagaga ccctggtgtg tccttcaagg ctgttggtct    840

acaacctgct ggagatgtaa atttgccatg acttcctgga ggacagcagc atggagaaag    900

atcctagaaa aggcctctga cttccctcac ctcccaacca tcattacagg aaagactgtg    960

aactcctgag ttcagcttga tttctgacta catcccagca agctctggca tctgtggatt   1020

aaaatccctg gatctctctc agttgtgtat ttgttcatct tcatatgctg gcaggaacaa   1080

ctattaatac agatactcag aagccaataa catgacagga gctgggactg gtttgaacac   1140

agggtgtgca gatggggagg gggtactggc cttgggcctc ctatgatgca gacatggtga   1200

atttaattca aggaggagga gaatgtttta ggcaggtggt tatatgtggg aagataattt   1260

tattcatgga tccaaatgtt tgttgagtcc tttctttgtg ctaaggttct tgcggtgaac   1320

cagaattata acagtgagct catctgactg ttttaggatg tacagcctag tgttaacatt   1380

cttggtatct ttttgtgcct tatctaaaac atttctcgat cactggtttc agatgttcat   1440

ttattatatt cttttcaaag attcagagat tggcttttgt catccactat tgtatgtttt   1500

gtttcattga cctctagtga taccttgatc tttcccactt tctgttttcg gattggagaa   1560

gatgtacctt ttttgtcaac tcttactttt atcagatgat caactcacgt atttggatct   1620

ttatttgttt tctcaaataa atatttaagg ttatacattt aaaaaaaaaa aaaaaaaaaa   1680

aaaaaaa                                                             1687


<210>  2495
<211>  277
<212>  PRT
<213>  Homosapiens

<400>  2495

Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu 
1               5                   10                  15      


Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala 
            20                  25                  30          


Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys 
        35                  40                  45              


Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln 
    50                  55                  60                  


Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala 
65                  70                  75                  80  


Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp 
                85                  90                  95      


Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile 
            100                 105                 110         


Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg 
        115                 120                 125             


Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met 
    130                 135                 140                 


Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln 
145                 150                 155                 160 


Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu 
                165                 170                 175     


Arg Lys Thr Gly Thr Gln Gln Glu Leu Asp Arg Val Phe Gln Lys Leu 
            180                 185                 190         


Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg 
        195                 200                 205             


Tyr Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu 
    210                 215                 220                 


Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro 
225                 230                 235                 240 


Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met Gly 
                245                 250                 255     


Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala Gly 
            260                 265                 270         


Asp Val Asn Leu Pro 
        275         


<210>  2496
<211>  1878
<212>  DNA
<213>  Homosapiens

<400>  2496
gattgtggga aggcagctga actcggcgcc tggaaagatg gaggcagcgg agacagaggc     60

ggaagctgca gccctagagg tcctggctga ggtggcaggc atcttggaac ctgtaggcct    120

gcaggaggag gcagaactgc cagccaagat cctggttgag tttgtggtgg actctcagaa    180

gaaagacaag ctgctctgca gccagcttca ggtagcggat ttcctgcaga acatcctggc    240

tcaggaggac actgctaagg gtctcgaccc cttggcttct gaagacacga gccgacagaa    300

ggcaattgca gctaaggaac aatggaaaga gctgaaggcc acctacaggg agcacgtaga    360

ggccatcaaa attggcctca ccaaggccct gactcagatg gaggaagccc agaggaaacg    420

gacacaactc cgggaagcct ttgagcagct ccaggccaag aaacaaatgg ccatggagaa    480

acgcagagca gtccagaacc agtggcagct acaacaggag aagcatctgc agcatctggc    540

ggaggtttct gcagaggtga gggagcgtaa gacagggact cagcaggagc ttgacagggt    600

gtttcagaaa cttggaaacc tgaagcagca ggcagaacag gagcgggaca agctgcagag    660

gtatcagacc ttcctccagc ttctgtatac cctgcagggt aagctgttgt tccctgaggc    720

tgaggctgag gcagagaatc ttccagatga taaaccccag cagccgactc gaccccagga    780

gcagagtaca ggagacacca tggggagaga ccctggtgtg tccttcaagg ctgttggtct    840

acaacctgct ggagatgtaa atttgccatg acttcctgga ggacagcagc atggagaaag    900

atcctagaaa aggtcagacc caactcaggc cttggtgtcc ctggactgca agtgtggaag    960

gagggaaagc ctggtttacc tctctctgca tctgagctct gctacccatg gagcagatgg   1020

atggtgggaa caggaaagag cttatgttac acctcattcc catgcttagc ccacccagag   1080

ctaacccctg tcttcttccc caggcctctg acttccctca cctcccaacc atcattacag   1140

gaaagactgt gaactcctga gttcagcttg atttctgact acatcccagc aagctctggc   1200

atctgtggat taaaatccct ggatctctct cagttgtgta tttgttcatc ttcatatgct   1260

ggcaggaaca actattaata cagatactca gaagccaata acatgacagg agctgggact   1320

ggtttgaaca cagggtgtgc agatggggag ggggtactgg ccttgggcct cctatgatgc   1380

agacatggtg aatttaattc aaggaggagg agaatgtttt aggcaggtgg ttatatgtgg   1440

gaagataatt ttattcatgg atccaaatgt ttgttgagtc ctttctttgt gctaaggttc   1500

ttgcggtgaa ccagaattat aacagtgagc tcatctgact gttttaggat gtacagccta   1560

gtgttaacat tcttggtatc tttttgtgcc ttatctaaaa catttctcga tcactggttt   1620

cagatgttca tttattatat tcttttcaaa gattcagaga ttggcttttg tcatccacta   1680

ttgtatgttt tgtttcattg acctctagtg ataccttgat ctttcccact ttctgttttc   1740

ggattggaga agatgtacct tttttgtcaa ctcttacttt tatcagatga tcaactcacg   1800

tatttggatc tttatttgtt ttctcaaata aatatttaag gttatacatt taaaaaaaaa   1860

aaaaaaaaaa aaaaaaaa                                                 1878


<210>  2497
<211>  277
<212>  PRT
<213>  Homosapiens

<400>  2497

Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu 
1               5                   10                  15      


Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala 
            20                  25                  30          


Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys 
        35                  40                  45              


Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln 
    50                  55                  60                  


Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala 
65                  70                  75                  80  


Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp 
                85                  90                  95      


Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile 
            100                 105                 110         


Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg 
        115                 120                 125             


Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met 
    130                 135                 140                 


Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln 
145                 150                 155                 160 


Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu 
                165                 170                 175     


Arg Lys Thr Gly Thr Gln Gln Glu Leu Asp Arg Val Phe Gln Lys Leu 
            180                 185                 190         


Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg 
        195                 200                 205             


Tyr Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu 
    210                 215                 220                 


Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro 
225                 230                 235                 240 


Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met Gly 
                245                 250                 255     


Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala Gly 
            260                 265                 270         


Asp Val Asn Leu Pro 
        275         


<210>  2498
<211>  4158
<212>  DNA
<213>  Homosapiens

<400>  2498
gttccccgcg gaggtggcag ccctgggccg cggcgttccg gaacccccgc acccacggcg     60

cggtgcccca cggtgcccgc gagcgccgcc cccgctggct agccgcgcct cgctccgccc    120

tggacgccgc cggtcccggc gcggaggtgc ggcggggagt gggagccggc ccggctcagt    180

ctgatttacg gctctgctga aaaccgcttc gctcccgcag catcagcacc ggaggcggcg    240

gctgcagcag cagcaacaag tcgggacttt tagagtaatg caacagaagg cttttgagga    300

aagcagatat ccctggcagg agtcctttga gaatgttgct gtgtgcctgc cattacgctg    360

cccgaggtgt ggagaccata ccagatttag aagcttgtca tccttgaggg cccatctgga    420

gttcagtcac agctacgaag aaagaaccct cttgacaaaa tgcagtctct ttccatccct    480

caaagacaca gacctagtca cttcctcaga actcctgaaa ccgggaaaat tgcagagcag    540

tggcaacgtg gtaaagcaga aaccgagcta tgttaacttg tacagcattt cacatgaaca    600

ttccaaggac aggaagccat ttgaggtggt ggcagagagg cctgtgtcct atgtgcagac    660

ctacactgcc atggacctcc atgcagactc gctggatggg acacggtcgg gtcctggact    720

gcccacctca gacaccaaag cttctttcga ggcacatgtc agagaaaaat tcaatcgaat    780

ggttgaggct gtggatagga ccattgagaa gagaattgat aaactcacca aagagttggc    840

ccagaaaact gcggaactgt tggaagttcg ggcagctttt gtgcagctga ctcagaaaaa    900

gcaggaagtt cagagacgag agcgggcctt aaacagacag gtggacgtgg ccgtggaaat    960

gatagctgta ctgaggcaac gcctgacgga atctgaggag gagcttctta ggaaagaaga   1020

agaagttgtc acattcaacc atttcctgga agcggcagct gagaaggagg ttcaagggaa   1080

agcccggctc caggacttta ttgagaatct gttacagcgg gtagaactgg cggagaagca   1140

gcttgagtac tatcagagcc agcaggcctc tggctttgtc cgtgatctca gcgggcacgt   1200

gcttacagac atctcctcaa ataggaagcc caaatgccta agccgagggc acccgcattc   1260

ggtatgtaac caccctgatc tcaagtccca tttccaccca aagggaagga accacctgaa   1320

aaaggccaag gatgacagag ccagcatgca gcctgccaag gccattcacg aacaggctga   1380

gtcctcaaga gacctctgca gacctccaaa gaaaggggag ctcctggggt ttggccgcaa   1440

aggcaacatc aggcccaaaa tggctaaaaa aaagccaaca gccattgtga acatcatcta   1500

aaagggtggg tggtgctgga ccaatcatcg ctgggctttg gggaacgttg ttccaggagc   1560

caacagtaat gtctttctgg aaacattcca tagtaagaca cattggaaaa gccaagggca   1620

taacacaggc aagcacctca attaaccaga gcttagcaaa tgggaatctt agtgaaccag   1680

aattttatta taaccccctt ttagaagctt gcaaattaca gaaagaataa aaaaattaaa   1740

tcaatcttaa agctctaact tctaaagtaa ctggcccagt ctccagtaat cttggcatct   1800

gggcttctat gcagtggtca ctaattttca ggaccaaggc cacacaaaat gtcaggccta   1860

gggagaaaat tcatctgtgc ccactgctct ccaaagtgcg aggcaaggaa tggcagtgta   1920

aagttctgtt aatagcagta aaatgaaaat atttgtgttt gtgtataacc ttcccctcag   1980

ctaatttgaa agcctccaaa ataaggattc ccattccccg agtattctgg ttaatcaaga   2040

tttcaatttc tgggttgctc aagggactcg ttcagtcaga cttcagttct cattccgaca   2100

gggtgtcttt cagttcgttt gtttgattga ggttttttgg tggcctagat gcatgtttat   2160

tcagattttg gtacacctct gccgtcttct ttggctgagt attctgcacc cacagaccat   2220

gctgccagcc tctatcttaa tagctgcttc tgtggatatg gctggggagc gaagtaaaat   2280

cctcttttga ttagcaccca gcatgggctg ggtggctagg tggttggaat gacagtggac   2340

tgcacgcttg gtgcatcgtg catcgtgacc atcctggaag cactgcgggt gtcgccaagc   2400

cctttcctaa gacctgcttc ccggccagtg tcagtggccc tctctctctc tgctatgggc   2460

atgactttct cttcgctggc ttaacttttc cactgggtgg ttcactttgc ctcctgctgc   2520

ttctgtgccc tgttaaggct tcaggtatct ttcaaccaag tatctggagt gttcactcta   2580

tgttgcattc taaagtaatt tctgaaataa acaatgcatg taggagccag aatctgacac   2640

tgtcttcccc tccttccctc cctaaaatgg ctttagtttc cacaaagagc tgttaagaat   2700

ttcctgctgt atgattttcc tcaagaatga atttccatgt tattttttcc ttaaatttag   2760

caatatcatc aggtctcttg cagagtttac aagtgctgac attcttctga aaacaggaat   2820

aattttgtcc acaaatatat acatatatac atatatataa cacatacaaa atatatatgt   2880

taagtatatt aataatttat ttttaaatac tcatggagaa agtgtgtgtt tgtggtgggt   2940

ggtttttaaa ctatatatgt ttgttcatgt aaactgaatt ctcttattta aaaaatcaaa   3000

actgtaacgt aattaacatt ggcagaatta tgattgttac tgcaataagc atcaaattag   3060

cagcgcatta aaaataggaa ataaagcagt tgcttaaaat gccagtcaat tgaaaagtgt   3120

aacttatcat tatacaaaca ttctgaacct accataatga aaatgttctt gaatcttcac   3180

tttgactttc agtttatggg ggggtagatc attcatgtga tatataagca gctatcaagt   3240

gggcaaaaac attgctgtga atagcactgt ttaggctaac attgtaaaaa ttgtaatgtt   3300

ataattatta tttatttgga gaattaactt ccccctctaa agttatttat tattgatgct   3360

tataccatga ttgcacctta gccttttaca tactaaaaac atgacttgtt agttgtattg   3420

catgctcttt gtcctgtaat gtgtgtgcaa tgacaacttg tttctgtttt atttaaagta   3480

actgacattt tggattttca tctaacatag agggcatggc aactctcttt gacagtggta   3540

ccccatgatc ttcagaaagt accataatgt catcctactc tacatttcac aagacgaatt   3600

attttgagat ttgtttatta tattaaaatg tttttttacg ttcccactaa attttgaccc   3660

catataaaga aatgtgttat gtatgttgtg cctccttaga gacataaatt tagtgtcaaa   3720

acatgggaga tggcttactc agaagcatac tccacttaac ataccatggc ctgagctaag   3780

taccatgtcc tgtttgtgtc ttatttttaa atattttctt tgtccacatg ggccgttgac   3840

cttagagtta aggcggttgc ttttttgaag aaatcaccaa agtttctggg aaactatgtt   3900

caaggttgaa atggagagta gatttaattt tatttgtctt gtagggaaga aatcttcctt   3960

tgaaccgctt ttcttgcttt ttcccttttt cccaaactag gttacaggtt cttatctgca   4020

aggttcaagt tgcttagaca ttgttttcca gtattctgca gggccagtca gttgtacaga   4080

agttggaata ttctgttcca gaattaaaga agtttttaga ttatgaaata ttatgataat   4140

aaagctatat ttctgact                                                 4158


<210>  2499
<211>  407
<212>  PRT
<213>  Homosapiens

<400>  2499

Met Gln Gln Lys Ala Phe Glu Glu Ser Arg Tyr Pro Trp Gln Glu Ser 
1               5                   10                  15      


Phe Glu Asn Val Ala Val Cys Leu Pro Leu Arg Cys Pro Arg Cys Gly 
            20                  25                  30          


Asp His Thr Arg Phe Arg Ser Leu Ser Ser Leu Arg Ala His Leu Glu 
        35                  40                  45              


Phe Ser His Ser Tyr Glu Glu Arg Thr Leu Leu Thr Lys Cys Ser Leu 
    50                  55                  60                  


Phe Pro Ser Leu Lys Asp Thr Asp Leu Val Thr Ser Ser Glu Leu Leu 
65                  70                  75                  80  


Lys Pro Gly Lys Leu Gln Ser Ser Gly Asn Val Val Lys Gln Lys Pro 
                85                  90                  95      


Ser Tyr Val Asn Leu Tyr Ser Ile Ser His Glu His Ser Lys Asp Arg 
            100                 105                 110         


Lys Pro Phe Glu Val Val Ala Glu Arg Pro Val Ser Tyr Val Gln Thr 
        115                 120                 125             


Tyr Thr Ala Met Asp Leu His Ala Asp Ser Leu Asp Gly Thr Arg Ser 
    130                 135                 140                 


Gly Pro Gly Leu Pro Thr Ser Asp Thr Lys Ala Ser Phe Glu Ala His 
145                 150                 155                 160 


Val Arg Glu Lys Phe Asn Arg Met Val Glu Ala Val Asp Arg Thr Ile 
                165                 170                 175     


Glu Lys Arg Ile Asp Lys Leu Thr Lys Glu Leu Ala Gln Lys Thr Ala 
            180                 185                 190         


Glu Leu Leu Glu Val Arg Ala Ala Phe Val Gln Leu Thr Gln Lys Lys 
        195                 200                 205             


Gln Glu Val Gln Arg Arg Glu Arg Ala Leu Asn Arg Gln Val Asp Val 
    210                 215                 220                 


Ala Val Glu Met Ile Ala Val Leu Arg Gln Arg Leu Thr Glu Ser Glu 
225                 230                 235                 240 


Glu Glu Leu Leu Arg Lys Glu Glu Glu Val Val Thr Phe Asn His Phe 
                245                 250                 255     


Leu Glu Ala Ala Ala Glu Lys Glu Val Gln Gly Lys Ala Arg Leu Gln 
            260                 265                 270         


Asp Phe Ile Glu Asn Leu Leu Gln Arg Val Glu Leu Ala Glu Lys Gln 
        275                 280                 285             


Leu Glu Tyr Tyr Gln Ser Gln Gln Ala Ser Gly Phe Val Arg Asp Leu 
    290                 295                 300                 


Ser Gly His Val Leu Thr Asp Ile Ser Ser Asn Arg Lys Pro Lys Cys 
305                 310                 315                 320 


Leu Ser Arg Gly His Pro His Ser Val Cys Asn His Pro Asp Leu Lys 
                325                 330                 335     


Ser His Phe His Pro Lys Gly Arg Asn His Leu Lys Lys Ala Lys Asp 
            340                 345                 350         


Asp Arg Ala Ser Met Gln Pro Ala Lys Ala Ile His Glu Gln Ala Glu 
        355                 360                 365             


Ser Ser Arg Asp Leu Cys Arg Pro Pro Lys Lys Gly Glu Leu Leu Gly 
    370                 375                 380                 


Phe Gly Arg Lys Gly Asn Ile Arg Pro Lys Met Ala Lys Lys Lys Pro 
385                 390                 395                 400 


Thr Ala Ile Val Asn Ile Ile 
                405         


<210>  2500
<211>  1671
<212>  DNA
<213>  Homosapiens

<400>  2500
gttccccgcg gaggtggcag ccctgggccg cggcgttccg gaacccccgc acccacggcg     60

cggtgcccca cggtgcccgc gagcgccgcc cccgctggct agccgcgcct cgctccgccc    120

tggacgccgc cggtcccggc gcggaggtgc ggcggggagt gggagccggc ccggctcagt    180

ctgatttacg gctctgctga aaaccgcttc gctcccgcag catcagcacc ggaggcggcg    240

gctgcagcag cagcaacaag tcgggacttt tagagtaatg caacagaagg cttttgagga    300

aagcagatat ccctggcagg agtcctttga gaatgttgct gtgtgcctgc cattacgctg    360

cccgaggtgt ggagaccata ccagatttag aagcttgtca tccttgaggg cccatctgga    420

gttcagtcac agctacgaag aaagaaccct cttgacaaaa tgcagtctct ttccatccct    480

caaagacaca gacctagtca cttcctcaga actcctgaaa ccgggaaaat tgcagagcag    540

tggcaacgtg gtaaagcaga aaccgagcta tgttaacttg tacagcattt cacatgaaca    600

ttccaaggac aggaagccat ttgaggtggt ggcagagagg cctgtgtcct atgtgcagac    660

ctacactgcc atggacctcc atgcagactc gctggatggg acacggtcgg gtcctggact    720

gcccacctca gacaccaaag cttctttcga ggcacatgtc agagaaaaat tcaatcgaat    780

ggttgaggct gtggatagga ccattgagaa gagaattgat aaactcacca aagagttggc    840

ccagaaaact gcggaactgt tggaagttcg ggcagctttt gtgcagctga ctcagaaaaa    900

gcaggaagtt cagagacgag agcgggcctt aaacagacag gtggacgtgg ccgtggaaat    960

gatagctgta ctgaggcaac gcctgacgga atctgaggag gagcttctta ggaaagaaga   1020

agaagttgtc acattcaacc atttcctgga agcggcagct gagaaggagg ttcaagggaa   1080

agcccggctc caggacttta ttgagaatct gttacagcgg gtagaactgg cggagaagca   1140

gcttgagtac tatcagagcc agcaggcctc tggctttgtc cgtgatctca gcgggcacgt   1200

gagctggaaa ggtgctggcg aagctcgcct ggtgtgccaa aatgacctgg aattggagga   1260

gtctgcgatt gtggaataat gaacttcgaa tgatgtgatt ctggatgagg acttggatca   1320

agagaatcgc aaattaattg tgccagagaa gctttcattc attcaacaaa tatttattaa   1380

gcatgtttta cactccagga actttacaag aaacttgggc tacttggtga ctttactcac   1440

caggagtggg ttcagactcc tgatggatga gctccaggtc ctccctaaca agactgcaga   1500

cttcctgagg gcacagccca cccctcatgc tttgagtttc tcatataacc catcatagca   1560

agtagaagat gcttcagaac atttgtccct atgagataga gtcatattct atttagcttg   1620

ggacatggca ggtactcagt tgttaaataa aaaatagtta ttgagtaatt t            1671


<210>  2501
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  2501

Met Gln Gln Lys Ala Phe Glu Glu Ser Arg Tyr Pro Trp Gln Glu Ser 
1               5                   10                  15      


Phe Glu Asn Val Ala Val Cys Leu Pro Leu Arg Cys Pro Arg Cys Gly 
            20                  25                  30          


Asp His Thr Arg Phe Arg Ser Leu Ser Ser Leu Arg Ala His Leu Glu 
        35                  40                  45              


Phe Ser His Ser Tyr Glu Glu Arg Thr Leu Leu Thr Lys Cys Ser Leu 
    50                  55                  60                  


Phe Pro Ser Leu Lys Asp Thr Asp Leu Val Thr Ser Ser Glu Leu Leu 
65                  70                  75                  80  


Lys Pro Gly Lys Leu Gln Ser Ser Gly Asn Val Val Lys Gln Lys Pro 
                85                  90                  95      


Ser Tyr Val Asn Leu Tyr Ser Ile Ser His Glu His Ser Lys Asp Arg 
            100                 105                 110         


Lys Pro Phe Glu Val Val Ala Glu Arg Pro Val Ser Tyr Val Gln Thr 
        115                 120                 125             


Tyr Thr Ala Met Asp Leu His Ala Asp Ser Leu Asp Gly Thr Arg Ser 
    130                 135                 140                 


Gly Pro Gly Leu Pro Thr Ser Asp Thr Lys Ala Ser Phe Glu Ala His 
145                 150                 155                 160 


Val Arg Glu Lys Phe Asn Arg Met Val Glu Ala Val Asp Arg Thr Ile 
                165                 170                 175     


Glu Lys Arg Ile Asp Lys Leu Thr Lys Glu Leu Ala Gln Lys Thr Ala 
            180                 185                 190         


Glu Leu Leu Glu Val Arg Ala Ala Phe Val Gln Leu Thr Gln Lys Lys 
        195                 200                 205             


Gln Glu Val Gln Arg Arg Glu Arg Ala Leu Asn Arg Gln Val Asp Val 
    210                 215                 220                 


Ala Val Glu Met Ile Ala Val Leu Arg Gln Arg Leu Thr Glu Ser Glu 
225                 230                 235                 240 


Glu Glu Leu Leu Arg Lys Glu Glu Glu Val Val Thr Phe Asn His Phe 
                245                 250                 255     


Leu Glu Ala Ala Ala Glu Lys Glu Val Gln Gly Lys Ala Arg Leu Gln 
            260                 265                 270         


Asp Phe Ile Glu Asn Leu Leu Gln Arg Val Glu Leu Ala Glu Lys Gln 
        275                 280                 285             


Leu Glu Tyr Tyr Gln Ser Gln Gln Ala Ser Gly Phe Val Arg Asp Leu 
    290                 295                 300                 


Ser Gly His Val Ser Trp Lys Gly Ala Gly Glu Ala Arg Leu Val Cys 
305                 310                 315                 320 


Gln Asn Asp Leu Glu Leu Glu Glu Ser Ala Ile Val Glu 
                325                 330             


<210>  2502
<211>  3376
<212>  DNA
<213>  Homosapiens

<400>  2502
gttccccgcg gaggtggcag ccctgggccg cggcgttccg gaacccccgc acccacggcg     60

cggtgcccca cggtgcccgc gagcgccgcc cccgctggct agccgcgcct cgctccgccc    120

tggacgccgc cggtcccggc gcggaggtgc ggcggggagt gggagccggc ccggctcagt    180

ctgatttacg gctctgctga aaaccgcttc gctcccgcag catcagcacc ggaggcggcg    240

gctgcagcag cagcaacaag tcgggacttt tagagtaatg caacagaagg cttttgagga    300

aagcagatat ccctggcagg agtcctttga gaatgttgct gtgtgcctgc cattacgctg    360

cccgaggtgt ggagaccata ccagatttag aagcttgtca tccttgaggg cccatctgga    420

gttcagtcac agctacgaag aaagaaccct cttgacaaaa tgcagtctct ttccatccct    480

caaagacaca gacctagtca cttcctcaga actcctgaaa ccgggaaaat tgcagagcag    540

tggcaacgtg gtaaagcaga aaccgagcta tgttaacttg tacagcattt cacatgaaca    600

ttccaaggac aggaagccat ttgaggtggt ggcagagagg cctgtgtcct atgtgcagac    660

ctacactgcc atggacctcc atgcagactc gctggatggg acacggtcgg gtcctggact    720

gcccacctca gacaccaaag cttctttcga ggcacatgtc agagaaaaat tcaatcgaat    780

ggttgaggct gtggatagga ccattgagaa gagaattgat aaactcacca aagagttggc    840

ccagaaaact gcggaactgt tggaagttcg ggcagctttt gtgcagctga ctcagaaaaa    900

gcaggaagtt cagagacgag agcgggcctt aaacagacag gtggacgtgg ccgtggaaat    960

gatagctgta ctgaggcaac gcctgacgga atctgaggag gagcttctta ggaaagaaga   1020

agaagttgtc acattcaacc atttcctgga agcggcagct gagaaggagg ttcaagggaa   1080

agcccggctc caggacttta ttgagaatct gttacagcgg gtagaactgg cggagaagca   1140

gcttgagtac tatcagagcc agcaggcctc tggctttgtc cgtgatctca gcgggcacgt   1200

gagctggaaa ggtgctggcg aagctcgcct ggtgtgccaa aatgacctgg aattggagat   1260

ttttggccat ataaaccacc atctttcggg gttgaaagat tctcattgtc tagtttttct   1320

gcaagcccca cctgtgccct ggatcatttt agccagcttt ctctggattc tcggaaatcc   1380

ctggacgtct tccacggcta ctgcaggatt tagccaaatt tgggtgctat ttcccttttg   1440

tggagggact tttcatcaca atgagaagga cgtcttagga ctccaggact ttgagagaga   1500

aagtgtctct acaagtcaaa gcaggaatat cagccttctt acactaggac aactccaaaa   1560

ttgtgtgatt ggcaaattga caatcatcga tttgttgact gaacacctgt taggtgtaag   1620

gcacggtgtc atatgctttc cttggggctt gccttcaagc agctaacaga aataagaaga   1680

aaacaggtga aaaagacagt gtgataaggc catggtggtg gattgtggat gccctgccct   1740

gtatccactt gggagagagc ctctacaaca tgctggcaac ttccccctca ctgattcaaa   1800

tgttaatctc ctttggcaac accctcacag acacacccag gatcaatacg ttgtatcctt   1860

tgatccaatc aagttgccac tcagtattaa ccatgacacc ttctaagcca tcatctcctc   1920

ctaatcctcc cataacaatg ggtataagtt atgaaggtgg gttagaaact agtgcctatc   1980

cctcactaag ttgccagatg gatttaacag cacctcaaag tcaacatgcc ccaagtcaaa   2040

gtcttcttta cccatggaat aagctggctt gctacttccc tacatctctg aagggctcca   2100

ccattcctct agcaaccatg ctctcaaagc tcagagggag gaaaaggaaa tggatctaaa   2160

tggaattcca ggtcccacgc tggatatttt cacaccttac ctcatttaat acaacaagca   2220

aggaggtaga caatattgtc tacctttgca aatgaggaaa cagaggctta gagaagttaa   2280

ataatttgcc tgagaataaa gctaaaagta gctttaaaat actagagctg ggattgcaag   2340

tttgatgcaa agtttgtgct ctcttcatcc ttcaccaaga tctttcattt tccctttaaa   2400

tatctcttat gtctgcattt cccttccatt cccatcacta gcactgtcct ctaatgcccc   2460

acccagtggg gaagtctcca ataggtcccc ctgcttataa cagccaagag ggtagctata   2520

aactaggtcc aataacatgc ttcatgtgag ggaactgatg gacagctgtc taattcataa   2580

cctctggcct caacggaatt tacagttcag agtccaaaat agcaaggaag tggtgggaag   2640

aaggtgagag aaaagggtgg gagggtgaga gaggggaggg aggggaataa ggtgtgggca   2700

gtagagggaa tctgtcagtc tcatggtttg ccctaggaaa ccttctgctc agccccagcc   2760

tgcttctggg cactcctcct cacccctcct tgctgtccat atgggttcaa tgtgagtaac   2820

cacaattgta gagtgtggcc atcttcttct gacatggtcc taaataaacc taactgagta   2880

gccagaagaa tcacttctaa ggtaaacatc tgtaaacatt ggttatattt attttcaata   2940

ttactggtta acattgtgga gctattactg atgggccaga ctctgtgcta ggcacagact   3000

ttctagggat tatttcattt aattctcatg gcaaccacca tgcatttgca gataggcaag   3060

tcaggctcac aaaaatgtat gcagagcttc agggttgtga tgggtagagc caaacccatc   3120

tgcccaaccc aagggcccgt gcgctccaac cctgcatcga actgccaaca tagtacacct   3180

tttagaaaaa gattcttgtt gcaaaagtac cataggcagt gtgtgtgtaa ggtcattgta   3240

aaagtgtaga taagcaagaa agtgttatac caccactcag aagtaaccac tgttaacatg   3300

ttggcttatc tgctctcagg tgtttctgtg cctgtacata ctattcttct tgaataaaaa   3360

caggattaca cagtgt                                                   3376


<210>  2503
<211>  462
<212>  PRT
<213>  Homosapiens

<400>  2503

Met Gln Gln Lys Ala Phe Glu Glu Ser Arg Tyr Pro Trp Gln Glu Ser 
1               5                   10                  15      


Phe Glu Asn Val Ala Val Cys Leu Pro Leu Arg Cys Pro Arg Cys Gly 
            20                  25                  30          


Asp His Thr Arg Phe Arg Ser Leu Ser Ser Leu Arg Ala His Leu Glu 
        35                  40                  45              


Phe Ser His Ser Tyr Glu Glu Arg Thr Leu Leu Thr Lys Cys Ser Leu 
    50                  55                  60                  


Phe Pro Ser Leu Lys Asp Thr Asp Leu Val Thr Ser Ser Glu Leu Leu 
65                  70                  75                  80  


Lys Pro Gly Lys Leu Gln Ser Ser Gly Asn Val Val Lys Gln Lys Pro 
                85                  90                  95      


Ser Tyr Val Asn Leu Tyr Ser Ile Ser His Glu His Ser Lys Asp Arg 
            100                 105                 110         


Lys Pro Phe Glu Val Val Ala Glu Arg Pro Val Ser Tyr Val Gln Thr 
        115                 120                 125             


Tyr Thr Ala Met Asp Leu His Ala Asp Ser Leu Asp Gly Thr Arg Ser 
    130                 135                 140                 


Gly Pro Gly Leu Pro Thr Ser Asp Thr Lys Ala Ser Phe Glu Ala His 
145                 150                 155                 160 


Val Arg Glu Lys Phe Asn Arg Met Val Glu Ala Val Asp Arg Thr Ile 
                165                 170                 175     


Glu Lys Arg Ile Asp Lys Leu Thr Lys Glu Leu Ala Gln Lys Thr Ala 
            180                 185                 190         


Glu Leu Leu Glu Val Arg Ala Ala Phe Val Gln Leu Thr Gln Lys Lys 
        195                 200                 205             


Gln Glu Val Gln Arg Arg Glu Arg Ala Leu Asn Arg Gln Val Asp Val 
    210                 215                 220                 


Ala Val Glu Met Ile Ala Val Leu Arg Gln Arg Leu Thr Glu Ser Glu 
225                 230                 235                 240 


Glu Glu Leu Leu Arg Lys Glu Glu Glu Val Val Thr Phe Asn His Phe 
                245                 250                 255     


Leu Glu Ala Ala Ala Glu Lys Glu Val Gln Gly Lys Ala Arg Leu Gln 
            260                 265                 270         


Asp Phe Ile Glu Asn Leu Leu Gln Arg Val Glu Leu Ala Glu Lys Gln 
        275                 280                 285             


Leu Glu Tyr Tyr Gln Ser Gln Gln Ala Ser Gly Phe Val Arg Asp Leu 
    290                 295                 300                 


Ser Gly His Val Ser Trp Lys Gly Ala Gly Glu Ala Arg Leu Val Cys 
305                 310                 315                 320 


Gln Asn Asp Leu Glu Leu Glu Ile Phe Gly His Ile Asn His His Leu 
                325                 330                 335     


Ser Gly Leu Lys Asp Ser His Cys Leu Val Phe Leu Gln Ala Pro Pro 
            340                 345                 350         


Val Pro Trp Ile Ile Leu Ala Ser Phe Leu Trp Ile Leu Gly Asn Pro 
        355                 360                 365             


Trp Thr Ser Ser Thr Ala Thr Ala Gly Phe Ser Gln Ile Trp Val Leu 
    370                 375                 380                 


Phe Pro Phe Cys Gly Gly Thr Phe His His Asn Glu Lys Asp Val Leu 
385                 390                 395                 400 


Gly Leu Gln Asp Phe Glu Arg Glu Ser Val Ser Thr Ser Gln Ser Arg 
                405                 410                 415     


Asn Ile Ser Leu Leu Thr Leu Gly Gln Leu Gln Asn Cys Val Ile Gly 
            420                 425                 430         


Lys Leu Thr Ile Ile Asp Leu Leu Thr Glu His Leu Leu Gly Val Arg 
        435                 440                 445             


His Gly Val Ile Cys Phe Pro Trp Gly Leu Pro Ser Ser Ser 
    450                 455                 460         


<210>  2504
<211>  2695
<212>  DNA
<213>  Homosapiens

<400>  2504
gaagaggaag agagacccga gctagcacac tcagtcccct tgctatgtga tgttctttac     60

catctcagga ctctgcacag agtccccaac agcaagaagg ccctcaccag atacagcccc    120

ttgacctggg acttctcagc ctccataacc gaattggccc ctacaagtca agttgcaaac    180

cctgggtcaa agggtgaagt agaaggaagc tggaaacaca tagtatttta gaagtttttc    240

agagaaatca caaggcagga acttctgctc agtttggaag aaagagcatt ccatcatgac    300

ccttggactg ggtgagagca tcatccttta attaatgtct gcgctgggtc agataaccat    360

cactgtctcc aggtgctgga atacagagag gaaccaaaca gataaaaatc cttgcctgca    420

cggagcttac cttcagctaa gggagacagt caaaaacaag tcaacacatc taaagaagcc    480

actgatgaaa caggctcccc cttggaaaga ccatctcgcc ttccaacctc tccatcctgc    540

agagaggaaa acccaagttt ggcgttggca gtcaggtaat tcatcagatc tggaaaccac    600

ctcatcagca tccccctggc caactggaag caaccgtgac gttgtgctga atacacttgc    660

agagtcgtgc tgtggtctct ccgagctcat cacggcacct ccctatgcag gagtttcaat    720

tcaaggattt agccaaattt gggtgctatt tcccttttgt ggagggactt ttcatcacaa    780

tgagaaggac gtcttaggac tccaggactt tgagagagaa agtgtctcta caagtcaaag    840

caggaatatc agccttctta cactaggaca actccaaaat tgtgtgattg gcaaattgac    900

aatcatcgat ttgttgactg aacacctgtt aggtgtaagg cacggtgtca tatgctttcc    960

ttggggcttg ccttcaagca gctaacagaa ataagaagaa aacaggtgaa aaagacagtg   1020

tgataaggcc atggtggtgg attgtggatg ccctgccctg tatccacttg ggagagagcc   1080

tctacaacat gctggcaact tccccctcac tgattcaaat gttaatctcc tttggcaaca   1140

ccctcacaga cacacccagg atcaatacgt tgtatccttt gatccaatca agttgccact   1200

cagtattaac catgacacct tctaagccat catctcctcc taatcctccc ataacaatgg   1260

gtataagtta tgaaggtggg ttagaaacta gtgcctatcc ctcactaagt tgccagatgg   1320

atttaacagc acctcaaagt caacatgccc caagtcaaag tcttctttac ccatggaata   1380

agctggcttg ctacttccct acatctctga agggctccac cattcctcta gcaaccatgc   1440

tctcaaagct cagagggagg aaaaggaaat ggatctaaat ggaattccag gtcccacgct   1500

ggatattttc acaccttacc tcatttaata caacaagcaa ggaggtagac aatattgtct   1560

acctttgcaa atgaggaaac agaggcttag agaagttaaa taatttgcct gagaataaag   1620

ctaaaagtag ctttaaaata ctagagctgg gattgcaagt ttgatgcaaa gtttgtgctc   1680

tcttcatcct tcaccaagat ctttcatttt ccctttaaat atctcttatg tctgcatttc   1740

ccttccattc ccatcactag cactgtcctc taatgcccca cccagtgggg aagtctccaa   1800

taggtccccc tgcttataac agccaagagg gtagctataa actaggtcca ataacatgct   1860

tcatgtgagg gaactgatgg acagctgtct aattcataac ctctggcctc aacggaattt   1920

acagttcaga gtccaaaata gcaaggaagt ggtgggaaga aggtgagaga aaagggtggg   1980

agggtgagag aggggaggga ggggaataag gtgtgggcag tagagggaat ctgtcagtct   2040

catggtttgc cctaggaaac cttctgctca gccccagcct gcttctgggc actcctcctc   2100

acccctcctt gctgtccata tgggttcaat gtgagtaacc acaattgtag agtgtggcca   2160

tcttcttctg acatggtcct aaataaacct aactgagtag ccagaagaat cacttctaag   2220

gtaaacatct gtaaacattg gttatattta ttttcaatat tactggttaa cattgtggag   2280

ctattactga tgggccagac tctgtgctag gcacagactt tctagggatt atttcattta   2340

attctcatgg caaccaccat gcatttgcag ataggcaagt caggctcaca aaaatgtatg   2400

cagagcttca gggttgtgat gggtagagcc aaacccatct gcccaaccca agggcccgtg   2460

cgctccaacc ctgcatcgaa ctgccaacat agtacacctt ttagaaaaag attcttgttg   2520

caaaagtacc ataggcagtg tgtgtgtaag gtcattgtaa aagtgtagat aagcaagaaa   2580

gtgttatacc accactcaga agtaaccact gttaacatgt tggcttatct gctctcaggt   2640

gtttctgtgc ctgtacatac tattcttctt gaataaaaac aggattacac agtgt        2695


<210>  2505
<211>  216
<212>  PRT
<213>  Homosapiens

<400>  2505

Met Ser Ala Leu Gly Gln Ile Thr Ile Thr Val Ser Arg Cys Trp Asn 
1               5                   10                  15      


Thr Glu Arg Asn Gln Thr Asp Lys Asn Pro Cys Leu His Gly Ala Tyr 
            20                  25                  30          


Leu Gln Leu Arg Glu Thr Val Lys Asn Lys Ser Thr His Leu Lys Lys 
        35                  40                  45              


Pro Leu Met Lys Gln Ala Pro Pro Trp Lys Asp His Leu Ala Phe Gln 
    50                  55                  60                  


Pro Leu His Pro Ala Glu Arg Lys Thr Gln Val Trp Arg Trp Gln Ser 
65                  70                  75                  80  


Gly Asn Ser Ser Asp Leu Glu Thr Thr Ser Ser Ala Ser Pro Trp Pro 
                85                  90                  95      


Thr Gly Ser Asn Arg Asp Val Val Leu Asn Thr Leu Ala Glu Ser Cys 
            100                 105                 110         


Cys Gly Leu Ser Glu Leu Ile Thr Ala Pro Pro Tyr Ala Gly Val Ser 
        115                 120                 125             


Ile Gln Gly Phe Ser Gln Ile Trp Val Leu Phe Pro Phe Cys Gly Gly 
    130                 135                 140                 


Thr Phe His His Asn Glu Lys Asp Val Leu Gly Leu Gln Asp Phe Glu 
145                 150                 155                 160 


Arg Glu Ser Val Ser Thr Ser Gln Ser Arg Asn Ile Ser Leu Leu Thr 
                165                 170                 175     


Leu Gly Gln Leu Gln Asn Cys Val Ile Gly Lys Leu Thr Ile Ile Asp 
            180                 185                 190         


Leu Leu Thr Glu His Leu Leu Gly Val Arg His Gly Val Ile Cys Phe 
        195                 200                 205             


Pro Trp Gly Leu Pro Ser Ser Ser 
    210                 215     


<210>  2506
<211>  4701
<212>  DNA
<213>  Homosapiens

<400>  2506
ggcgaggccg gcggctgccg ggcctccaat ctcggcggcg gcggcggcaa caggggagcc     60

tgggtctcgc ggcctgcgag tccgtcgcgt gctgagggag acgcaggagg tggagccggc    120

cgggtgctcg agggaaggag actggaagct ggttccggcg tgaggagagt ctgaaaaagg    180

ggagcgcgga gaggaggctg gaagaggaag atgcctagca cagaccttct gatgttgaag    240

gcctttgagc cctacttaga gattttggaa gtatactcca caaaagccaa gaattatgta    300

aatggacatt gcaccaagta tgagccctgg cagctaattg catggagtgt cgtgtggacc    360

ctgctgatag tctggggata tgagtttgtc ttccagccag agagtttatg gtcaaggttt    420

aaaaagaaat gttttaagct caccaggaag atgcccatta ttggtcgtaa gattcaagac    480

aagttgaaca agaccaagga tgatattagc aagaacatgt cattcctgaa agtggacaaa    540

gagtatgtga aagctttacc ctcccagggt ctgagctcat ctgctgtttt ggagaaactt    600

aaggagtaca gctctatgga cgccttctgg caagagggga gagcctctgg aacagtgtac    660

agtggggagg agaagctcac tgagctcctt gtgaaggctt atggagattt tgcatggagt    720

aaccccctgc atccagatat cttcccagga ctacgcaaga tagaggcaga aattgtgagg    780

atagcttgtt ccctgttcaa tgggggacca gattcgtgtg gatgtgtgac ttctggggga    840

acagaaagca tactgatggc ctgcaaagca tatcgggatc tggcctttga gaaggggatc    900

aaaactccag aaattgtggc tccccaaagt gcccatgctg catttaacaa agcagccagt    960

tactttggga tgaagattgt gcgggtccca ttgacgaaga tgatggaggt ggatgtgcgg   1020

gcaatgagaa gagctatctc caggaacact gccatgctcg tctgttctac cccacagttt   1080

cctcatggtg taatagatcc tgtccctgaa gtggccaagc tggctgtcaa atacaaaata   1140

ccccttcatg tcgacgcttg tctgggaggc ttcctcatcg tctttatgga gaaagcagga   1200

tacccactgg agcacccatt tgatttccgg gtgaaaggtg taaccagcat ttcagctgac   1260

acccataagt atggctatgc cccaaaaggc tcatcattgg tgttgtatag tgacaagaag   1320

tacaggaact atcagttctt cgtcgataca gattggcagg gtggcatcta tgcttcccca   1380

accatcgcag gctcacggcc tggtggcatt agcgcagcct gttgggctgc cttgatgcac   1440

ttcggtgaga acggctatgt tgaagctacc aaacagatca tcaaaactgc tcgcttcctc   1500

aagtcagaac tggaaaatat caaaggcatc tttgtttttg ggaatcccca attgtcagtc   1560

attgctctgg gatcccgtga ttttgacatc taccgactat caaacctgat gactgctaag   1620

gggtggaact tgaaccagtt gcagttccca cccagtattc atttctgcat cacattacta   1680

cacgcccgga aacgagtagc tatacaattc ctaaaggaca ttcgagaatc tgtcactcaa   1740

atcatgaaga atcctaaagc gaagaccaca ggaatgggtg ccatctatgg catggcccag   1800

acaactgttg acaggaatat ggttgcagaa ttgtcctcag tcttcttgga cagcttgtac   1860

agcaccgaca ctgtcaccca gggcagccag atgaatggtt ctccaaaacc ccactgaact   1920

tggacccttt ctagtctcaa ggggattcca gccttcagaa ggttcttggg atatggaaca   1980

ggccgtgcac aactttgaca tctggtcttg ctccatagag cacaactcaa gatagaccat   2040

gagacagctt gagcctcagg attcttgttc ttcctcttat cttccttttg tggtttttaa   2100

tttgaagacc ccagagaatt ccattacata atgattttgc ccttgttata aatgttaccc   2160

taggaattgt tttaaccatt tccttttcta aactctctag ctttcaactt tacttaaaca   2220

ttgtgtggta gctctgacct gtcctgattc tttagagaag ctggggtaca gtttatgaga   2280

tagctagagc ttctttgtta tctcaggcag gaggcgttta cataacagat gtttcctcag   2340

ctgggtgtga ggtatactct aagcaggagg ctttttcagc cttctctctc tttttttttt   2400

tttttttttt ttgagatgga attttgctct tttgcccagt ctggagtgca gtggcatgat   2460

ctcagctcac tgcaacctcc acccactggg ttcaagcgat tcttctgcct cagcctcccg   2520

agtagctggg attaccggca cccaccacca cgcctggcta atttttcaat tttctttttc   2580

agtagagacg ggttcaccgt gttggccagg ctggtcttga actcctgacc tcaggtgata   2640

cccgcccccc cgcctcagcc tcccaaagtg ctgggattac aggcgtgagc caccgtgcct   2700

ggccctgtct ctcttaagag taggttcatt gtctgtctta gagtcacttc tattgcaact   2760

cattttcttt ttccagggca cagatcgacc aagctgccgt tccctattct gcaggacagg   2820

actattctag catacctgct tcgtccaccc aggcagggtt tggggtggtc tcttctgtgc   2880

ctgcagtccc catttgacac ttggttgcca ccatctttgg agattattgt ttggaatgat   2940

gcttccattg gctttttctt gttaccatgg actaggaaga aaacatggtt tccaaataat   3000

ctgggagctt ttggccatgg tgccgccttc ctgaattggc agtggtcaga gcacacctga   3060

accctatcct gggctggtga tgagcagaaa tcagaccttt ttctatgctt ttttgaatat   3120

cagagtagga tgaacaccca gattcaaata tgtcaccaaa gttggtggtg gtccttccct   3180

gcacccttgc gttaagccat tatgtaatga aaatgtgttt gcttgaagga acagctcaaa   3240

gcaccttcac aagttgcctt gacttaccct aggtgggtgt gaaagagcac ccgtagcaag   3300

gaaaattttc tctattagtg tgttcttctg cctcttcccc cttgattcag ctttcagagg   3360

tactatggca gttttgcctc aggtgctgaa catttctcag ccctggctaa aagggagcag   3420

cacagggaga gaaacaggat aggaaagcag aatggcgagc agcctatggc ccagggcctg   3480

taatcccttc ccaagactag ctgctcaggg tggtgcaggg acaggaccag accctgcgcc   3540

tatttcctgc cttctttccc ctatagggaa ctctgtaggc tgagccactg tcctgctctt   3600

atgacattat atcttgtgcc tttctcctca gcagtgagca gtgagctact cctggcccag   3660

gccctagggg aaatggatca gtctttgagg tttctatttg gggaggggag tacttaagat   3720

gagtcaaaag acactttcct ctgttccatt ccccatctca gggactcctg aatattcagc   3780

ctctccaggc tggtgtcttc tagtttcccc cactgggaat gctggctggg agagccatga   3840

ctaccagact tttcctcagg ctccttggca tgttagtctg aattgttctt gagcactgta   3900

ctactgaccc aacaactgtg actagctggc cacgccattc agggctggtg tggcatttat   3960

gtgtgtgtgt gtgtgtgtgt gtttttcctg tttgcccagc agtgcattgt gggttccaag   4020

agtgggtagt gtgtgtatgt gtgtgtgtca gagggagacc tggcaggcac ctctttgaga   4080

gtagctgtgg tcagagctgt ttggtcagtg cattatgttg aatgaggtcc aggaacccag   4140

agccacccag cagacaccac tgtggcttgc cagctgccaa gatggagaag catgtgcccc   4200

tgtagagcgt ctccccagaa ccagaccccg agccactcgc ttcctctgtg ctgtgacaac   4260

attggtgcca ggggagatgg tgtttttcaa agggacctac tgtagccact ttaatttaca   4320

attaagagcc ttagtttgac ttaacacttt tgtaggcttt tcattgtgta tttttgtgta   4380

tgtgtgcata tagcagctac tctgtagcag aggtgggtag agacacttaa tagtatcatg   4440

tcgcatgcag atgtcacatc ggcctctgca aaaactgtac tgtcttgttt ctgcattaga   4500

cttaagtagt catgtgaata tactgctatg tcacttttaa tattacgagt tttatacttg   4560

gaaaatggta cttgcttctt ttaaatctct gtcttctcta acctccccct tcccatttca   4620

atgctccctt cctaatttca gcaataatct caaaaagcaa ttaaatagtt aaatgaccct   4680

aattgtaaaa aaaaaaaaaa a                                             4701


<210>  2507
<211>  568
<212>  PRT
<213>  Homosapiens

<400>  2507

Met Pro Ser Thr Asp Leu Leu Met Leu Lys Ala Phe Glu Pro Tyr Leu 
1               5                   10                  15      


Glu Ile Leu Glu Val Tyr Ser Thr Lys Ala Lys Asn Tyr Val Asn Gly 
            20                  25                  30          


His Cys Thr Lys Tyr Glu Pro Trp Gln Leu Ile Ala Trp Ser Val Val 
        35                  40                  45              


Trp Thr Leu Leu Ile Val Trp Gly Tyr Glu Phe Val Phe Gln Pro Glu 
    50                  55                  60                  


Ser Leu Trp Ser Arg Phe Lys Lys Lys Cys Phe Lys Leu Thr Arg Lys 
65                  70                  75                  80  


Met Pro Ile Ile Gly Arg Lys Ile Gln Asp Lys Leu Asn Lys Thr Lys 
                85                  90                  95      


Asp Asp Ile Ser Lys Asn Met Ser Phe Leu Lys Val Asp Lys Glu Tyr 
            100                 105                 110         


Val Lys Ala Leu Pro Ser Gln Gly Leu Ser Ser Ser Ala Val Leu Glu 
        115                 120                 125             


Lys Leu Lys Glu Tyr Ser Ser Met Asp Ala Phe Trp Gln Glu Gly Arg 
    130                 135                 140                 


Ala Ser Gly Thr Val Tyr Ser Gly Glu Glu Lys Leu Thr Glu Leu Leu 
145                 150                 155                 160 


Val Lys Ala Tyr Gly Asp Phe Ala Trp Ser Asn Pro Leu His Pro Asp 
                165                 170                 175     


Ile Phe Pro Gly Leu Arg Lys Ile Glu Ala Glu Ile Val Arg Ile Ala 
            180                 185                 190         


Cys Ser Leu Phe Asn Gly Gly Pro Asp Ser Cys Gly Cys Val Thr Ser 
        195                 200                 205             


Gly Gly Thr Glu Ser Ile Leu Met Ala Cys Lys Ala Tyr Arg Asp Leu 
    210                 215                 220                 


Ala Phe Glu Lys Gly Ile Lys Thr Pro Glu Ile Val Ala Pro Gln Ser 
225                 230                 235                 240 


Ala His Ala Ala Phe Asn Lys Ala Ala Ser Tyr Phe Gly Met Lys Ile 
                245                 250                 255     


Val Arg Val Pro Leu Thr Lys Met Met Glu Val Asp Val Arg Ala Met 
            260                 265                 270         


Arg Arg Ala Ile Ser Arg Asn Thr Ala Met Leu Val Cys Ser Thr Pro 
        275                 280                 285             


Gln Phe Pro His Gly Val Ile Asp Pro Val Pro Glu Val Ala Lys Leu 
    290                 295                 300                 


Ala Val Lys Tyr Lys Ile Pro Leu His Val Asp Ala Cys Leu Gly Gly 
305                 310                 315                 320 


Phe Leu Ile Val Phe Met Glu Lys Ala Gly Tyr Pro Leu Glu His Pro 
                325                 330                 335     


Phe Asp Phe Arg Val Lys Gly Val Thr Ser Ile Ser Ala Asp Thr His 
            340                 345                 350         


Lys Tyr Gly Tyr Ala Pro Lys Gly Ser Ser Leu Val Leu Tyr Ser Asp 
        355                 360                 365             


Lys Lys Tyr Arg Asn Tyr Gln Phe Phe Val Asp Thr Asp Trp Gln Gly 
    370                 375                 380                 


Gly Ile Tyr Ala Ser Pro Thr Ile Ala Gly Ser Arg Pro Gly Gly Ile 
385                 390                 395                 400 


Ser Ala Ala Cys Trp Ala Ala Leu Met His Phe Gly Glu Asn Gly Tyr 
                405                 410                 415     


Val Glu Ala Thr Lys Gln Ile Ile Lys Thr Ala Arg Phe Leu Lys Ser 
            420                 425                 430         


Glu Leu Glu Asn Ile Lys Gly Ile Phe Val Phe Gly Asn Pro Gln Leu 
        435                 440                 445             


Ser Val Ile Ala Leu Gly Ser Arg Asp Phe Asp Ile Tyr Arg Leu Ser 
    450                 455                 460                 


Asn Leu Met Thr Ala Lys Gly Trp Asn Leu Asn Gln Leu Gln Phe Pro 
465                 470                 475                 480 


Pro Ser Ile His Phe Cys Ile Thr Leu Leu His Ala Arg Lys Arg Val 
                485                 490                 495     


Ala Ile Gln Phe Leu Lys Asp Ile Arg Glu Ser Val Thr Gln Ile Met 
            500                 505                 510         


Lys Asn Pro Lys Ala Lys Thr Thr Gly Met Gly Ala Ile Tyr Gly Met 
        515                 520                 525             


Ala Gln Thr Thr Val Asp Arg Asn Met Val Ala Glu Leu Ser Ser Val 
    530                 535                 540                 


Phe Leu Asp Ser Leu Tyr Ser Thr Asp Thr Val Thr Gln Gly Ser Gln 
545                 550                 555                 560 


Met Asn Gly Ser Pro Lys Pro His 
                565             


<210>  2508
<211>  1025
<212>  DNA
<213>  Homosapiens

<400>  2508
cggggtggga ttccaaccca gaagcgggca tttggagccc tcatgcttca ccctagctcc     60

ctgaaacaag cacggaggat ggctctgagc agcgaggaaa gtgctggaag caagcaggcc    120

gagcgcgtcc ctggctgggg acgttaatca ttaccggagg gcggcccgag cgcggccccg    180

ccccgggacg gcagcctgcg cgcccggccg ccgcctgccc tctccgctgg ccacctgctg    240

ccgcccgcgc catggctggc aaagcacaca ggctgagcgc tgaggagagg gaccagctgc    300

tgccaaacct gagggctgtg gggtggaatg agctggaagg ccgtgatgcc atcttcaagc    360

agtttcattt caaagacttc aacagggcct ttgggttcat gacaagagtg gccctgcagg    420

ctgagaaact ggaccaccat cctgaatggt ttaacgtgta caacaaggtc cacatcacgc    480

tgagcaccca tgagtgtgcc ggcctttcag aacgggacat aaacctggcc agcttcatcg    540

aacaagtagc agtgtccatg acatagaccc tgcccttcct ctttgaattc ttccggggga    600

aggggtgact gaactgggag tccagggagg gagctgagga gcccttaccc tcccaccact    660

cccctcccaa gacccagccg ccgccgttga gggctgagtc cttgctgtgg gatgtgccag    720

tgtccccacc aacaccagga atttagacct tttccctgca ccactctctt catcctgggg    780

gctctgttac actaatttga ataaactctc ccctttcttt gcaacttccc agcaacaata    840

atgattttct tgccaggccg tctcttgctc cctaattcat ttcccaggaa gctgtgatac    900

agggtgaaat aaagtcttgt cttagaaacc aggaccctaa accccacact atgtaataga    960

aacacatgtg tttttatgtc tcaaataaaa ctattatatc acttggaaaa aaaaaaaaaa   1020

aaaaa                                                               1025


<210>  2509
<211>  104
<212>  PRT
<213>  Homosapiens

<400>  2509

Met Ala Gly Lys Ala His Arg Leu Ser Ala Glu Glu Arg Asp Gln Leu 
1               5                   10                  15      


Leu Pro Asn Leu Arg Ala Val Gly Trp Asn Glu Leu Glu Gly Arg Asp 
            20                  25                  30          


Ala Ile Phe Lys Gln Phe His Phe Lys Asp Phe Asn Arg Ala Phe Gly 
        35                  40                  45              


Phe Met Thr Arg Val Ala Leu Gln Ala Glu Lys Leu Asp His His Pro 
    50                  55                  60                  


Glu Trp Phe Asn Val Tyr Asn Lys Val His Ile Thr Leu Ser Thr His 
65                  70                  75                  80  


Glu Cys Ala Gly Leu Ser Glu Arg Asp Ile Asn Leu Ala Ser Phe Ile 
                85                  90                  95      


Glu Gln Val Ala Val Ser Met Thr 
            100                 


<210>  2510
<211>  3935
<212>  DNA
<213>  Homosapiens

<400>  2510
cccacgcgtc cgggctaggg cgccggagcc gcacgcagcc gcggggctcc gagaggcgcg     60

cactggggct gggactgcgc ggcgccgccg ctgcgagcgc cactgagcgg tcgcgcaact    120

tcggaggcac agcgccggag ccaggcgagc gctcagagac ccggagccag aggggcgcgc    180

cggagcctcg ttcgagagcc ggcgccaggc acccaccgcg ctccgagtgc caggcggccc    240

tccgcgcagc gtggcttccg ctgcccccac ggaaggcacg ggctggcgct gccgggcgcc    300

ggggaggacg gcgaggagga ggcggcggcg gcggagacgg cggcggcgag actggggcca    360

gggagacagc cctgggggag aggcgcccga accaggccgc gggagcatgg gggcccggag    420

cggagctcgg ggcgcgctgc tgctggcact gctgctctgc tgggacccga ggctgagcca    480

agcaggcact gattctggca gcgaggtgct ccctgactcc ttcccgtcag cgccagcaga    540

gccgctgccc tacttcctgc aggagccaca ggacgcctac attgtgaaga acaagcctgt    600

ggagctccgc tgccgcgcct tccccgccac acagatctac ttcaagtgca acggcgagtg    660

ggtcagccag aacgaccacg tcacacagga aggcctggat gaggccaccg gcctgcgggt    720

gcgcgaggtg cagatcgagg tgtcgcggca gcaggtggag gagctctttg ggctggagga    780

ttactggtgc cagtgcgtgg cctggagctc cgcgggcacc accaagagtc gccgagccta    840

cgtccgcatc gcctacctgc gcaagaactt cgatcaggag cctctgggca aggaggtgcc    900

cctggaccat gaggttctcc tgcagtgccg cccgccggag ggggtgcctg tggccgaggt    960

ggaatggctc aagaatgagg atgtcatcga ccccacccag gacaccaact tcctgctcac   1020

catcgaccac aacctcatca tccgccaggc ccgcctgtcg gacactgcca actatacctg   1080

cgtggccaag aacatcgtgg ccaaacgccg gagcaccact gccaccgtca tcgtctacgt   1140

gaatggcggc tggtccagct gggcagagtg gtcaccctgc tccaaccgct gtggccgagg   1200

ctggcagaag cgcacccgga cctgcaccaa ccccgctcca ctcaacggag gggccttctg   1260

cgagggccag gcattccaga agaccgcctg caccaccatc tgcccagtcg atggggcgtg   1320

gacggagtgg agcaagtggt cagcctgcag cactgagtgt gcccactggc gtagccgcga   1380

gtgcatggcg cccccacccc agaacggagg ccgtgactgc agcgggacgc tgctcgactc   1440

taagaactgc acagatgggc tgtgcatgca aaataagaaa actctaagcg accccaacag   1500

ccacctgctg gaggcctcag gggatgcggc gctgtatgcg gggctcgtgg tggccatctt   1560

cgtggtcgtg gcaatcctca tggcggtggg ggtggtggtg taccgccgca actgccgtga   1620

cttcgacaca gacatcactg actcatctgc tgccctgact ggtggtttcc accccgtcaa   1680

ctttaagacg gcaaggccca gcaacccgca gctcctacac ccctctgtgc ctcctgacct   1740

gacagccagc gccggcatct accgcggacc cgtgtatgcc ctgcaggact ccaccgacaa   1800

aatccccatg accaactctc ctctgctgga ccccttaccc agccttaagg tcaaggtcta   1860

cagctccagc accacgggct ctgggccagg cctggcagac ggggctgacc tgctgggggt   1920

cttgccgcct ggcacatacc ctagcgattt cgcccgggac acccacttcc tgcacctgcg   1980

cagcgccagc ctcggttccc agcagctctt gggcctgccc cgagacccag ggagcagcgt   2040

cagcggcacc tttggctgcc tgggtgggag gctcagcatc cccggcacag gggtcagctt   2100

gctggtgccc aatggagcca ttccccaggg caagttctac gagatgtatc tactcatcaa   2160

caaggcagaa agtaccctcc cgctttcaga agggacccag acagtattga gcccctcggt   2220

gacctgtgga cccacaggcc tcctgctgtg ccgccccgtc atcctcacca tgccccactg   2280

tgccgaagtc agtgcccgtg actggatctt tcagctcaag acccaggccc accagggcca   2340

ctgggaggag gtggtgaccc tggatgagga gaccctgaac acaccctgct actgccagct   2400

ggagcccagg gcctgtcaca tcctgctgga ccagctgggc acctacgtgt tcacgggcga   2460

gtcctattcc cgctcagcag tcaagcggct ccagctggcc gtcttcgccc ccgccctctg   2520

cacctccctg gagtacagcc tccgggtcta ctgcctggag gacacgcctg tagcactgaa   2580

ggaggtgctg gagctggagc ggactctggg cggatacttg gtggaggagc cgaaaccgct   2640

aatgttcaag gacagttacc acaacctgcg cctctccctc catgacctcc cccatgccca   2700

ttggaggagc aagctgctgg ccaaatacca ggagatcccc ttctatcaca tttggagtgg   2760

cagccagaag gccctccact gcactttcac cctggagagg cacagcttgg cctccacaga   2820

gctcacctgc aagatctgcg tgcggcaagt ggaaggggag ggccagatat tccagctgca   2880

taccactctg gcagagacac ctgctggctc cctggacact ctctgctctg cccctggcag   2940

cactgtcacc acccagctgg gaccttatgc cttcaagatc ccactgtcca tccgccagaa   3000

gatatgcaac agcctagatg cccccaactc acggggcaat gactggcgga tgttagcaca   3060

gaagctctct atggaccggt acctgaatta ctttgccacc aaagcgagcc ccacgggtgt   3120

gatcctggac ctctgggaag ctctgcagca ggacgatggg gacctcaaca gcctggcgag   3180

tgccttggag gagatgggca agagtgagat gctggtggct gtggccaccg acggggactg   3240

ctgagcctcc tgggacagcg ggctggcagg gactggcagg aggcaggtgc agggaggcct   3300

ggggcagcct cctgatgggg atgtttggcc tctgcttcct cccagttcac agccagagtt   3360

gcctctcctc ctcctcttcc ccaaccccca gaccatgacc agccttagaa aatccatgta   3420

ctctgttgtt agagggccca gagttccttc tccacccccg ctctctctct cttggcctga   3480

gatctctgtg caggaaccaa gatggggctg aagcctctgg aggcagttgg ttgggggcgg   3540

gcaggcagga ggccctccct ccaccccccc accctcagcc cggcaacttc tgggttccat   3600

gggttttagt tccgttctcg ttttcttcct ccgttattga tttctccttt ctccctaagc   3660

ccccttctgc ttccacgccc ttttcctctt tgaagagtca agtacaattc agacaaactg   3720

ctttctcctg tccaaaagca aaaaggcaaa ggaaagaaag aaagcttcag accgctagta   3780

aggctcaaag aagaagaaaa acaccaaaac cacaagggaa aagaaaaacc cagtttctta   3840

ggaaacgcaa acgatttatt atccagatta tttggataag tcctttttaa gaaaaaaaaa   3900

agaaaatgaa aaacaacaca aaaaaaaaaa aaaaa                              3935


<210>  2511
<211>  945
<212>  PRT
<213>  Homosapiens

<400>  2511

Met Gly Ala Arg Ser Gly Ala Arg Gly Ala Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Leu Cys Trp Asp Pro Arg Leu Ser Gln Ala Gly Thr Asp Ser Gly Ser 
            20                  25                  30          


Glu Val Leu Pro Asp Ser Phe Pro Ser Ala Pro Ala Glu Pro Leu Pro 
        35                  40                  45              


Tyr Phe Leu Gln Glu Pro Gln Asp Ala Tyr Ile Val Lys Asn Lys Pro 
    50                  55                  60                  


Val Glu Leu Arg Cys Arg Ala Phe Pro Ala Thr Gln Ile Tyr Phe Lys 
65                  70                  75                  80  


Cys Asn Gly Glu Trp Val Ser Gln Asn Asp His Val Thr Gln Glu Gly 
                85                  90                  95      


Leu Asp Glu Ala Thr Gly Leu Arg Val Arg Glu Val Gln Ile Glu Val 
            100                 105                 110         


Ser Arg Gln Gln Val Glu Glu Leu Phe Gly Leu Glu Asp Tyr Trp Cys 
        115                 120                 125             


Gln Cys Val Ala Trp Ser Ser Ala Gly Thr Thr Lys Ser Arg Arg Ala 
    130                 135                 140                 


Tyr Val Arg Ile Ala Tyr Leu Arg Lys Asn Phe Asp Gln Glu Pro Leu 
145                 150                 155                 160 


Gly Lys Glu Val Pro Leu Asp His Glu Val Leu Leu Gln Cys Arg Pro 
                165                 170                 175     


Pro Glu Gly Val Pro Val Ala Glu Val Glu Trp Leu Lys Asn Glu Asp 
            180                 185                 190         


Val Ile Asp Pro Thr Gln Asp Thr Asn Phe Leu Leu Thr Ile Asp His 
        195                 200                 205             


Asn Leu Ile Ile Arg Gln Ala Arg Leu Ser Asp Thr Ala Asn Tyr Thr 
    210                 215                 220                 


Cys Val Ala Lys Asn Ile Val Ala Lys Arg Arg Ser Thr Thr Ala Thr 
225                 230                 235                 240 


Val Ile Val Tyr Val Asn Gly Gly Trp Ser Ser Trp Ala Glu Trp Ser 
                245                 250                 255     


Pro Cys Ser Asn Arg Cys Gly Arg Gly Trp Gln Lys Arg Thr Arg Thr 
            260                 265                 270         


Cys Thr Asn Pro Ala Pro Leu Asn Gly Gly Ala Phe Cys Glu Gly Gln 
        275                 280                 285             


Ala Phe Gln Lys Thr Ala Cys Thr Thr Ile Cys Pro Val Asp Gly Ala 
    290                 295                 300                 


Trp Thr Glu Trp Ser Lys Trp Ser Ala Cys Ser Thr Glu Cys Ala His 
305                 310                 315                 320 


Trp Arg Ser Arg Glu Cys Met Ala Pro Pro Pro Gln Asn Gly Gly Arg 
                325                 330                 335     


Asp Cys Ser Gly Thr Leu Leu Asp Ser Lys Asn Cys Thr Asp Gly Leu 
            340                 345                 350         


Cys Met Gln Asn Lys Lys Thr Leu Ser Asp Pro Asn Ser His Leu Leu 
        355                 360                 365             


Glu Ala Ser Gly Asp Ala Ala Leu Tyr Ala Gly Leu Val Val Ala Ile 
    370                 375                 380                 


Phe Val Val Val Ala Ile Leu Met Ala Val Gly Val Val Val Tyr Arg 
385                 390                 395                 400 


Arg Asn Cys Arg Asp Phe Asp Thr Asp Ile Thr Asp Ser Ser Ala Ala 
                405                 410                 415     


Leu Thr Gly Gly Phe His Pro Val Asn Phe Lys Thr Ala Arg Pro Ser 
            420                 425                 430         


Asn Pro Gln Leu Leu His Pro Ser Val Pro Pro Asp Leu Thr Ala Ser 
        435                 440                 445             


Ala Gly Ile Tyr Arg Gly Pro Val Tyr Ala Leu Gln Asp Ser Thr Asp 
    450                 455                 460                 


Lys Ile Pro Met Thr Asn Ser Pro Leu Leu Asp Pro Leu Pro Ser Leu 
465                 470                 475                 480 


Lys Val Lys Val Tyr Ser Ser Ser Thr Thr Gly Ser Gly Pro Gly Leu 
                485                 490                 495     


Ala Asp Gly Ala Asp Leu Leu Gly Val Leu Pro Pro Gly Thr Tyr Pro 
            500                 505                 510         


Ser Asp Phe Ala Arg Asp Thr His Phe Leu His Leu Arg Ser Ala Ser 
        515                 520                 525             


Leu Gly Ser Gln Gln Leu Leu Gly Leu Pro Arg Asp Pro Gly Ser Ser 
    530                 535                 540                 


Val Ser Gly Thr Phe Gly Cys Leu Gly Gly Arg Leu Ser Ile Pro Gly 
545                 550                 555                 560 


Thr Gly Val Ser Leu Leu Val Pro Asn Gly Ala Ile Pro Gln Gly Lys 
                565                 570                 575     


Phe Tyr Glu Met Tyr Leu Leu Ile Asn Lys Ala Glu Ser Thr Leu Pro 
            580                 585                 590         


Leu Ser Glu Gly Thr Gln Thr Val Leu Ser Pro Ser Val Thr Cys Gly 
        595                 600                 605             


Pro Thr Gly Leu Leu Leu Cys Arg Pro Val Ile Leu Thr Met Pro His 
    610                 615                 620                 


Cys Ala Glu Val Ser Ala Arg Asp Trp Ile Phe Gln Leu Lys Thr Gln 
625                 630                 635                 640 


Ala His Gln Gly His Trp Glu Glu Val Val Thr Leu Asp Glu Glu Thr 
                645                 650                 655     


Leu Asn Thr Pro Cys Tyr Cys Gln Leu Glu Pro Arg Ala Cys His Ile 
            660                 665                 670         


Leu Leu Asp Gln Leu Gly Thr Tyr Val Phe Thr Gly Glu Ser Tyr Ser 
        675                 680                 685             


Arg Ser Ala Val Lys Arg Leu Gln Leu Ala Val Phe Ala Pro Ala Leu 
    690                 695                 700                 


Cys Thr Ser Leu Glu Tyr Ser Leu Arg Val Tyr Cys Leu Glu Asp Thr 
705                 710                 715                 720 


Pro Val Ala Leu Lys Glu Val Leu Glu Leu Glu Arg Thr Leu Gly Gly 
                725                 730                 735     


Tyr Leu Val Glu Glu Pro Lys Pro Leu Met Phe Lys Asp Ser Tyr His 
            740                 745                 750         


Asn Leu Arg Leu Ser Leu His Asp Leu Pro His Ala His Trp Arg Ser 
        755                 760                 765             


Lys Leu Leu Ala Lys Tyr Gln Glu Ile Pro Phe Tyr His Ile Trp Ser 
    770                 775                 780                 


Gly Ser Gln Lys Ala Leu His Cys Thr Phe Thr Leu Glu Arg His Ser 
785                 790                 795                 800 


Leu Ala Ser Thr Glu Leu Thr Cys Lys Ile Cys Val Arg Gln Val Glu 
                805                 810                 815     


Gly Glu Gly Gln Ile Phe Gln Leu His Thr Thr Leu Ala Glu Thr Pro 
            820                 825                 830         


Ala Gly Ser Leu Asp Thr Leu Cys Ser Ala Pro Gly Ser Thr Val Thr 
        835                 840                 845             


Thr Gln Leu Gly Pro Tyr Ala Phe Lys Ile Pro Leu Ser Ile Arg Gln 
    850                 855                 860                 


Lys Ile Cys Asn Ser Leu Asp Ala Pro Asn Ser Arg Gly Asn Asp Trp 
865                 870                 875                 880 


Arg Met Leu Ala Gln Lys Leu Ser Met Asp Arg Tyr Leu Asn Tyr Phe 
                885                 890                 895     


Ala Thr Lys Ala Ser Pro Thr Gly Val Ile Leu Asp Leu Trp Glu Ala 
            900                 905                 910         


Leu Gln Gln Asp Asp Gly Asp Leu Asn Ser Leu Ala Ser Ala Leu Glu 
        915                 920                 925             


Glu Met Gly Lys Ser Glu Met Leu Val Ala Val Ala Thr Asp Gly Asp 
    930                 935                 940                 


Cys 
945 


<210>  2512
<211>  5316
<212>  DNA
<213>  Homosapiens

<400>  2512
cggacgcgtg ggaacgaagc cacccattac ggtatgatga tgtcaaacgt gatgctgatg     60

ctacagttac agcccctgct ggcgcagcct ctctgattct ctctccctct ccgcgtccag    120

tgctgggctt tttcagacaa gtgcatctcc taaccaggtc acatttcagc cgcgacccac    180

tctccgccag tcaccggagg cagaccgcgg gaggagagct gaggacagcc gcgtgcgctt    240

cgccagcagc ggggtgggag gaaggacatt aaaatactgc agaagtcaag accccccagg    300

tcgaacccag accacgatgc gcgccccggg ctgcgggcgg ctggtgctgc cgctgctgct    360

cctggccgcg gcagccctgg ccgaaggcga cgccaagggg ctcaaggagg gcgagacccc    420

cggcaatttc atggaggacg agcaatggct gtcgtccatc tcgcagtaca gcggcaagat    480

caagcactgg aaccgcttcc gagacgaagt ggaggatgac tatatcaaga gctgggagga    540

caatcagcaa ggagatgaag ccctggatac caccaaggac ccctgccaga aggtgaagtg    600

cagccgccac aaggtgtgca ttgcccaggg ctaccagcgg gccatgtgca tcagtcgcaa    660

gaagctggag cacaggatca agcagccgac cgtgaaactc catggaaaca aagactccat    720

ctgcaagccc tgccacatgg cccagcttgc ctctgtctgc ggctcagatg gccacactta    780

cagctctgtg tgtaagctgg agcaacaggc gtgcctgagc agcaagcagc tggcggtgcg    840

atgcgagggc ccctgcccct gccccacgga gcaggctgcc acctccaccg ccgatggcaa    900

accagagact tgcaccggtc aggacctggc tgacctggga gatcggctgc gggactggtt    960

ccagctcctt catgagaact ccaagcagaa tggctcagcc agcagtgtag ccggcccggc   1020

cagcgggctg gacaagagcc tgggggccag ctgcaaggac tccattggct ggatgttctc   1080

caagctggac accagtgctg acctcttcct ggaccagacg gagctggccg ccatcaacct   1140

ggacaagtac gaggtctgca tccgtccctt cttcaactcc tgtgacacct acaaggatgg   1200

ccgggtctct actgctgagt ggtgcttctg cttctggagg gagaagcccc cctgcctggc   1260

agagctggag cgcatccaga tccaggaggc cgccaagaag aagccaggca tcttcatccc   1320

gagctgcgac gaggatggct actaccggaa gatgcagtgt gaccagagca gcggtgactg   1380

ctggtgtgtg gaccagctgg gcctggagct gactggcacg cgcacgcatg ggagccccga   1440

ctgcgatgac atcgtgggct tctcggggga ctttggaagc ggtgtcggct gggaggatga   1500

ggaggagaag gagacggagg aagcaggcga ggaggccgag gaggaggagg gcgaggcagg   1560

cgaggctgac gacgggggct acatctggta gacgccctca gaagccggct gccggggggg   1620

actcaacagc agagctctga gcagcagcag gcaacttcga gaacggatcc agaaatgcag   1680

tcagaaggac cctgctccac ctggggggac tgggagtgtg agtgtgcatg gcatgtgtgt   1740

ggcacagatg gctgggacgg gtgacagtgt gagtgcatgt gtgcatgcat gtgtgtatgt   1800

gtgtgtgtgt gtggcatgcg ctgacaaatg tgtccttgat ccacactgct cctggcagag   1860

tgagtaaccc aaaggcccct tcggcctcct tgtagctgtt ttctttcctt ttgttgttgg   1920

ttttaaaata cattcacaca caaatacaaa ttgacaggtc aaaatccatg aaatgagatc   1980

ccccagccgt gtcctccagc ccagccctga ccccttggtt tctaccctgg ctccccttgg   2040

tttctaccct ggctcaaccg acccctgtct gcccttctcc ctcctgcttc tgaggtcaag   2100

ctctggcctg cgagcctgtc cccattgcaa aggggaggga ggggcaggga gctgtctacc   2160

agctgaggtc ctcccaaaac tgggccgatg tggtgtgaca tccccaccag cctcagatga   2220

gacgggccag gacgcccagc cacagcaagc cctgtccctt tgccggatcc ccaaacacta   2280

gagaagctct cctaacccaa ggcggagaat gaaggtggtg gcggcagagg aggagggcag   2340

cagctgagag gccagggaca gggtgcctcg ccaagctgtc tgaggtctgt cccaggtggc   2400

ccaggtggtg caggtagaac agggtgagga gagggggtcg gctcaacagg aggaggctgt   2460

ggctgcagag cctggaggag cttttaggtg ttgagatggg gcagctctga atcctagacc   2520

ctggaatagc ctgtcccttt tctctgggtc tcgtggtgga gccatgatct gggctgctct   2580

cttggggaca ctgggtggtg gttacacagt tgacctctgc ctggctcccc cttggtgcaa   2640

ctcctgcctc catccccctt gctggggtcc cctcatccac ttgagggcgc ctgagggcca   2700

ggagcagcag gcaaggagcc tgggtctagg ctaagggggt gtgtgcccac ctcctccctg   2760

acccttaaca ctcctgtcct gcccagacca acagagagag ctgtccctga gaccccggag   2820

agaagcagct gccgaaagct gcagcctttc cgcactctga gaccatgatc ttcctcctgc   2880

caggggagag ccacccacag gccatgtcca gccccacttc cctcagcccc cagggcttcc   2940

ttctggcccc tctgaggatt ccctagggct gccccgcaga ggggcttccc caagctctgt   3000

tttgaagcct gcaatgtgga aaagtgagaa gtcagaggga acaggacagg tgcagccggg   3060

ctctgaggcc acacctcaca cctcgctgtt ccccaacatc ccctgagcag tgtgagctca   3120

tctcaccaga tgagaagagg ccctgtgcat ttcttttgtt tgtttgttgc tgttttcccc   3180

cacccatcca gttctcctca gcaaagcaaa ttccttaaca cctttggtgg agaatttctt   3240

acccagactt ggggctgtga tgcccttcag tgcgtggtga gtgcagcgtg tgtgcgtgtg   3300

cctgtgtgtg aacctggggg ccatcctggt ggcctgggag cgtgaggaga ggccccctgt   3360

gtgctgggtg agtggtgggt gtggggtcaa tgcagtgagg ctctctgggt gaggctccca   3420

acctggcagt ccccagcctc ccagcatctg tgagcgtctg ttggacttta cagaagagcc   3480

tcatcccgtc tgcccctcac tctgccctgg aatcaacatc ttccgagtcc ttcttggggg   3540

aaatagcaga gccccactta actccataaa ctgcttccca ttccgcagcc cagttctgat   3600

tgttgaggtg tcgcgtcgtt ccaggtcccc cagtcccctc tttctcctgt cctctctctg   3660

tccttcacct ccccactcca gccccggctc agttcaggga aatgctgttc catatcagcc   3720

ctctgctctc tgaggcagcc gcgcctctga ctcggagcta cttgaaactt ctgctcttgc   3780

taggattgga gtctacctat ctcttccatt tgtcccagct ggagttctgg aactttcctc   3840

ctcggggtgg gggtgggggt tgttaaggat gctggggggc ctggggaagg aaggagttca   3900

gaggaagggt gtcccctgtc ctcttgatgt caccctccgc tcctgggaca cgtgctctct   3960

ctgtctctgg gtcttctggc tgtgcacgtt tgtgtgtcct tgtaaatatg ttttaggaag   4020

aaagcaaaag ggactgaact agcctctggt aggattgcag gggtccagcc ttgcctgttt   4080

ccgaagcccc cacactgcct ttcgccccac tgagactggt cccctcaaaa ggtagacaaa   4140

acagcagctc cctgtggagc tgaagggcgg cctcaaagtg gctttttgtt agacaaggtt   4200

aaggtttcct catgagcaag gttgcagatc ggtccttcct cagctccttg atttgtgacc   4260

ttgaccaagg ggcctgccac ccagcccctc cagtgccctc tcctcgatgc ctcgctcctt   4320

cctgccccca ctcccctggc ttaggcaggt aggggaatta gggccatgct ggaagaagct   4380

taaccatgtg ttcaaagaac ggtttcttgc ttgcttggtc ctggaactcc ccttggctgc   4440

cccaggcctc cttggcccat gggtgctggg ggaggtggat gtcagatctg gtaggttgca   4500

gcagagaaaa taaatgtgcc ttgagagacc actcagagag ggtccaaggg tgatggagaa   4560

ggaagcatgg cctgggagct tggaagggag gggtggtggg tggcggcatc ttgactgccc   4620

cctgttgtcc cacacgtggg gggtggtcac cccccttcac tccagcccgc ctgccttcag   4680

ccttccatga gcttcacctg cttccaactt cactttggag ggggtggggt ccgttggcat   4740

caacacgggg accctctgct tcaccaaagc ccgagccctc agcccctggg gagaacaaat   4800

ggctgagctt tgatacctgg ggtcgtcgag aggctgcggg ctggcggcag tcccagggga   4860

gagacaccac agaaggagac ccagacatcc cgaggaagtt cccagcagag caaactgctt   4920

tccagcctga agcctgctta aactgtgtga tgtgcaataa ctgagcttag agttaggaat   4980

tgtgttcaag tgcttggatt tccgtctgta gatttaactg ctgaaattgt atctctcagt   5040

aattttagat gtcttttaaa aaattgaaaa acaaagtgtt agactgtgtg cgtgtgcgtt   5100

gatgggcact caagagtccc gtgagtcatc cagccctgcc tttcccctgc gcccccatcc   5160

tctcacgtcc cgccctgcct ccacttgggg accctgcctc gtgtcgtctt tatctgccta   5220

ttactcagcc taaggaaaca agtacactcc acacatgcat aaaggaaatc aaatgttatt   5280

tttaagaaaa tggaaaataa aaactttata aacacc                             5316


<210>  2513
<211>  424
<212>  PRT
<213>  Homosapiens

<400>  2513

Met Arg Ala Pro Gly Cys Gly Arg Leu Val Leu Pro Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Leu Ala Glu Gly Asp Ala Lys Gly Leu Lys Glu Gly 
            20                  25                  30          


Glu Thr Pro Gly Asn Phe Met Glu Asp Glu Gln Trp Leu Ser Ser Ile 
        35                  40                  45              


Ser Gln Tyr Ser Gly Lys Ile Lys His Trp Asn Arg Phe Arg Asp Glu 
    50                  55                  60                  


Val Glu Asp Asp Tyr Ile Lys Ser Trp Glu Asp Asn Gln Gln Gly Asp 
65                  70                  75                  80  


Glu Ala Leu Asp Thr Thr Lys Asp Pro Cys Gln Lys Val Lys Cys Ser 
                85                  90                  95      


Arg His Lys Val Cys Ile Ala Gln Gly Tyr Gln Arg Ala Met Cys Ile 
            100                 105                 110         


Ser Arg Lys Lys Leu Glu His Arg Ile Lys Gln Pro Thr Val Lys Leu 
        115                 120                 125             


His Gly Asn Lys Asp Ser Ile Cys Lys Pro Cys His Met Ala Gln Leu 
    130                 135                 140                 


Ala Ser Val Cys Gly Ser Asp Gly His Thr Tyr Ser Ser Val Cys Lys 
145                 150                 155                 160 


Leu Glu Gln Gln Ala Cys Leu Ser Ser Lys Gln Leu Ala Val Arg Cys 
                165                 170                 175     


Glu Gly Pro Cys Pro Cys Pro Thr Glu Gln Ala Ala Thr Ser Thr Ala 
            180                 185                 190         


Asp Gly Lys Pro Glu Thr Cys Thr Gly Gln Asp Leu Ala Asp Leu Gly 
        195                 200                 205             


Asp Arg Leu Arg Asp Trp Phe Gln Leu Leu His Glu Asn Ser Lys Gln 
    210                 215                 220                 


Asn Gly Ser Ala Ser Ser Val Ala Gly Pro Ala Ser Gly Leu Asp Lys 
225                 230                 235                 240 


Ser Leu Gly Ala Ser Cys Lys Asp Ser Ile Gly Trp Met Phe Ser Lys 
                245                 250                 255     


Leu Asp Thr Ser Ala Asp Leu Phe Leu Asp Gln Thr Glu Leu Ala Ala 
            260                 265                 270         


Ile Asn Leu Asp Lys Tyr Glu Val Cys Ile Arg Pro Phe Phe Asn Ser 
        275                 280                 285             


Cys Asp Thr Tyr Lys Asp Gly Arg Val Ser Thr Ala Glu Trp Cys Phe 
    290                 295                 300                 


Cys Phe Trp Arg Glu Lys Pro Pro Cys Leu Ala Glu Leu Glu Arg Ile 
305                 310                 315                 320 


Gln Ile Gln Glu Ala Ala Lys Lys Lys Pro Gly Ile Phe Ile Pro Ser 
                325                 330                 335     


Cys Asp Glu Asp Gly Tyr Tyr Arg Lys Met Gln Cys Asp Gln Ser Ser 
            340                 345                 350         


Gly Asp Cys Trp Cys Val Asp Gln Leu Gly Leu Glu Leu Thr Gly Thr 
        355                 360                 365             


Arg Thr His Gly Ser Pro Asp Cys Asp Asp Ile Val Gly Phe Ser Gly 
    370                 375                 380                 


Asp Phe Gly Ser Gly Val Gly Trp Glu Asp Glu Glu Glu Lys Glu Thr 
385                 390                 395                 400 


Glu Glu Ala Gly Glu Glu Ala Glu Glu Glu Glu Gly Glu Ala Gly Glu 
                405                 410                 415     


Ala Asp Asp Gly Gly Tyr Ile Trp 
            420                 


<210>  2514
<211>  2090
<212>  DNA
<213>  Homosapiens

<400>  2514
ggaattccgg gtcctcctcc tcgccctacc ttggtttacc tgcagccgcc tagtcctctt     60

ctccttctct ttgatgattc agggcctcgg cttccctcac gatattgcag aaagacacag    120

ctttcctctt cctctccaaa ccacctcgaa gcaggggcat aattggaata tcatttggag    180

aaagtgtcat ggaagttctg cgtccacagc ttataagaat tgatggccgg aattacagga    240

agaatccagt ccaagaacag acctatcaac atgaagaaga tgaagaggac ttctatcaag    300

gctccatgga gtgtgctgat gagccctgtg atgcctacga ggtggagcag accccacaag    360

gattccggtc tactttgagg gcccccagct tgctctataa gcatatagtt ggaaagagag    420

gggacactag gaagaaaata gaaatggaga ccaaaacttc tattagcatt cctaaacctg    480

gacaagacgg ggaaattgta atcactggcc agcatcgaaa tggtgtaatt tcagcccgaa    540

cacggattga tgttcttttg gacacttttc gaagaaagca gcccttcact cacttccttg    600

cctttttcct caatgaagtt gaggttcagg aaggattcct gagattccag gaggaagtac    660

tggcgaagtg ctccatggat catggggttg acagcagcat tttccagaat cctaaaaagc    720

ttcatctaac tattgggatg ttggtgcttt tgagtgagga agagatccag cagacatgtg    780

agatgctaca gcagtgtaaa gaggaattca ttaatgatat ttctgggggt aaacccctag    840

aagtggagat ggcagggata gaatacatga atgatgatcc tggcatggtg gatgttcttt    900

acgccaaagt ccatatgaaa gatggctcca acaggctaca agaattagtt gatcgagtgc    960

tggaacgttt tcaggcatct ggactaatag tgaaagagtg gaatagtgtg aaactgcatg   1020

ctacagttat gaatacacta ttcaggaaag accccaatgc tgaaggcagg tacaatctct   1080

acacagcgga aggcaaatat atcttcaagg aaagagaatc atttgatggc cgaaatattt   1140

taaagttgtt tgagaacttc tactttggct ccctaaagct gaattcaatt cacatctctc   1200

agaggttcac cgtagacagc tttggaaact acgcttcctg tggacaaatt gacttctcct   1260

gaggtggatc ttggaaagca ctagaaacta aacatcttca ccaggtgctg aagaaaagtg   1320

tcttcgtttt aattgccaag cagggatgtg gacatttgga tggtgacttt cctgggtggt   1380

tccccataga ttcaccattg cctctaatgg tgtctacacc cgtcatacta ccagctgaga   1440

tggtggtggg cataaggaga atttgtgcct ataaccctta gtgtgttctg gttttttttc   1500

ttttaatttt taaattgtcg taaaatactc ataaaacata ctgtcttcac catttttaag   1560

tgcacagttc agtaacgtta actgttaata cattcataat gctgtgtggc cgtcaccgcc   1620

gtccatctcc ataggcttct cagcttgtaa aatggaaact gtacccatta aacagtaatt   1680

cccactcctc ccagcccccg cagccaccat tctgctttct gtctctctgg ttttgactat   1740

tctcagtatc tcatataagt ggaatcatac agtgacttgt ctttttgtga ctggcttatt   1800

tcacttagca taatgtcctc aaggttcatc catgttgtgt caggtgacag gatttccttc   1860

ctgtattata catataatgg aatgttccgt tacatgtgcg taccacactc tgttcctcca   1920

tcagtgaaca cttggcttgc ttcctcttga ctattgggag tagtgctaat acagacacgg   1980

gggtgcaaat atctctttga gactctgcct ttaattcctt taccacccag agttttatct   2040

ttagcaaaat aaccattaaa gttgtttgcc ttttacgaaa aaaaaaaaaa              2090


<210>  2515
<211>  357
<212>  PRT
<213>  Homosapiens

<400>  2515

Met Glu Val Leu Arg Pro Gln Leu Ile Arg Ile Asp Gly Arg Asn Tyr 
1               5                   10                  15      


Arg Lys Asn Pro Val Gln Glu Gln Thr Tyr Gln His Glu Glu Asp Glu 
            20                  25                  30          


Glu Asp Phe Tyr Gln Gly Ser Met Glu Cys Ala Asp Glu Pro Cys Asp 
        35                  40                  45              


Ala Tyr Glu Val Glu Gln Thr Pro Gln Gly Phe Arg Ser Thr Leu Arg 
    50                  55                  60                  


Ala Pro Ser Leu Leu Tyr Lys His Ile Val Gly Lys Arg Gly Asp Thr 
65                  70                  75                  80  


Arg Lys Lys Ile Glu Met Glu Thr Lys Thr Ser Ile Ser Ile Pro Lys 
                85                  90                  95      


Pro Gly Gln Asp Gly Glu Ile Val Ile Thr Gly Gln His Arg Asn Gly 
            100                 105                 110         


Val Ile Ser Ala Arg Thr Arg Ile Asp Val Leu Leu Asp Thr Phe Arg 
        115                 120                 125             


Arg Lys Gln Pro Phe Thr His Phe Leu Ala Phe Phe Leu Asn Glu Val 
    130                 135                 140                 


Glu Val Gln Glu Gly Phe Leu Arg Phe Gln Glu Glu Val Leu Ala Lys 
145                 150                 155                 160 


Cys Ser Met Asp His Gly Val Asp Ser Ser Ile Phe Gln Asn Pro Lys 
                165                 170                 175     


Lys Leu His Leu Thr Ile Gly Met Leu Val Leu Leu Ser Glu Glu Glu 
            180                 185                 190         


Ile Gln Gln Thr Cys Glu Met Leu Gln Gln Cys Lys Glu Glu Phe Ile 
        195                 200                 205             


Asn Asp Ile Ser Gly Gly Lys Pro Leu Glu Val Glu Met Ala Gly Ile 
    210                 215                 220                 


Glu Tyr Met Asn Asp Asp Pro Gly Met Val Asp Val Leu Tyr Ala Lys 
225                 230                 235                 240 


Val His Met Lys Asp Gly Ser Asn Arg Leu Gln Glu Leu Val Asp Arg 
                245                 250                 255     


Val Leu Glu Arg Phe Gln Ala Ser Gly Leu Ile Val Lys Glu Trp Asn 
            260                 265                 270         


Ser Val Lys Leu His Ala Thr Val Met Asn Thr Leu Phe Arg Lys Asp 
        275                 280                 285             


Pro Asn Ala Glu Gly Arg Tyr Asn Leu Tyr Thr Ala Glu Gly Lys Tyr 
    290                 295                 300                 


Ile Phe Lys Glu Arg Glu Ser Phe Asp Gly Arg Asn Ile Leu Lys Leu 
305                 310                 315                 320 


Phe Glu Asn Phe Tyr Phe Gly Ser Leu Lys Leu Asn Ser Ile His Ile 
                325                 330                 335     


Ser Gln Arg Phe Thr Val Asp Ser Phe Gly Asn Tyr Ala Ser Cys Gly 
            340                 345                 350         


Gln Ile Asp Phe Ser 
        355         


<210>  2516
<211>  3277
<212>  DNA
<213>  Homosapiens

<400>  2516
cgaacacgcc gcggtcctcg tcgtggtgag cgcagccact caggctggtc ctgggggtgg     60

ggctgtaggg gaaagtgcta aagccgctga gtgaagtaag aactctgcta gagaggaaat    120

ggctgcttca tcatcatcct cctcagctgg tggggtcagt ggaagttctg tcactggatc    180

tggtttcagt gtctcagacc ttgccccacc acggaaagcc cttttcacct accccaaagg    240

agctggagag atgttagaag atggctctga gagattcctc tgcgaatctg tttttagcta    300

tcaagtggca tccacgctta aacaggtgaa acatgatcag caagttgctc ggatggaaaa    360

actagctggt ttggtagaag agctggaggc tgacgagtgg cggtttaagc ccatcgagca    420

gctgctggga ttcaccccct cttcaggttg atactgcctg gatggtcacc tctggtgcgc    480

agcaagtgca aagccagtgg gggactttct cacagcttac atagccatcc agagatccac    540

agctacgtca ctgaattgtt aatgcacatt tgtacttggt ttctctgtat ctattcacag    600

gcaacaaata cttatatgtg tgatctttca gggaatgttt tgtttatttg tttttaaaag    660

tattgggaat cagattaaga caatcagttt cagagaacca ggaggtttgg ggttaagaga    720

tactcaaaaa ttttcacaag ccaagtaggg catatatcag atttggccaa ctgaatggcg    780

tctgtcctgt catccatatg gtgcctggaa atatttacca gtcaaggtca aggtcagcat    840

ctgtggttaa aaatatagca ttctgaccta aaaaagttat tttgcagatg aatgtgtttt    900

caactcagga cctatccaaa tgaggaattt ttaaatattc tttttttttt cctattttta    960

gacatcaatt ctatagattc tgactttttc taacctctta tagacatgcc aaatgctggc   1020

aaaaagaagt gctttttgga tatggcagca cttgtaaaaa taaagcagta agcaaaatcc   1080

ttttaaacac agaaatcctg agttcttctc attggtggac tcaagcaatt ctgtagcaaa   1140

taaatccttt gaaagagctc caaattggtg gcattatcct ttcaaaatct cagggatttg   1200

ggatgaagtg aagaggtcaa attacttttt agaagaaggg aatctaaaaa ccatctctcc   1260

taaacaaatg gtagactggc tttacttaag ggatatttgt ctttatagga gtacataaat   1320

ttatcttaat gatatttaag tagttttttt ttttttttgg gacgaagttt tgctcttgtt   1380

gcccaggctg tatcgcaatg gcgcggtctc tgctcactgc agcatccgcc tcccgggttc   1440

gggcggttct cctgcctcag cctcccgagt agctgggatt acaggcgccc gccaccacac   1500

ccagctaatt ttttgtatat ttggtagaga cggggtttca ccgtgttgac caggctggtc   1560

tcgagcttct ggcctcaggt gatccacctg cctcagcctc ccaaattgct gggattgcag   1620

gcgtgagcca ccttgcccag ccaatttttt tttaaagaga catggtcttg ctatgttgcc   1680

caggttggtc ttgaactcct ggcctcaaga gatcccccca accttggcct ccaaagtgct   1740

gggattacag gcatgagcca ccgcgcctgg cctcaagtaa gtttttatac catgataggg   1800

gaaaacctgg aaggctaaga gatgtgctgt tttccttcat gggaccccac tttccacagt   1860

aaacaactgg tataatcatt tattacgttg tatgcaaatt ttgccttaga caacatttgt   1920

ctggttcctt attaataact tgcatctgat ctgcttagag ttgcttaatt ataagtaaat   1980

ataatcccag tagcatttag ccttaatctc aagagttcaa aatgtttaac acattctacc   2040

tgacgggagg tggtgacctc attcagtcgg ttaagagcct gagccctgtg aagttaaaca   2100

cctgctcatg gtcacatagc ccaggcagaa gaaaatctcg gacttggaat agatcccagt   2160

tgcctgataa ttcatctcat tattgcctct aaagcaaatt ggagactggg cacagtggct   2220

cccaccttta atcccagcac ctggggaggc tgaggtgagt ggatcactag aggtcaggag   2280

ttcaagacca gtctggccga catggtgaaa ctcagtctct attgaaaata caaaaattag   2340

ctcagtgtgg tggcacacac ttgtaatccc agctactcag gaggctgagg catgagaatc   2400

gcttaaaccc aggaggcgga ggttgcagtg agctgagatc acaccattgc actctagtct   2460

gggtgacaga gcgagactct gtctcaaaaa aaaaaaaata aagccgggcg tggtggctca   2520

cgcctgtaat cccggcactt tgggaggctg aggcaggcgg attgcctgag atcgggagtt   2580

cgagaccagc ctggccaaca tggtgaaacc ttgtctctac taaaactaca aaaaaaattg   2640

gccaggcgtg gtggcgggcg cctgtaatcc cagctactcg ggaggctgag gcagcagaat   2700

cgtttgaacc cgggaggcgg aggttgcagt gagtggagat cgtgcctgtg tgctccagcc   2760

tgagcaacaa gagcgaaact gtctcaaaaa aaagaagaaa ataaataaat aaaaatcaga   2820

gcacaagaag taccagtcca ccaactcaca ttttctatat taataattct taactaaaag   2880

aagttccata ttcgacagca ttttagtttt ttaatagtac ttattagcat caaccatctt   2940

gataatcacc aagggaaaaa ttaaaaatac ctagactgca ataaaccttt aaattggatt   3000

ttcagtgaga atttagaagc aatcactacc tttctcgttt catttgtgta accatgcagc   3060

ataggcactg tgttacatca tctttacgct ttggtatttg aacttattac agaatttttt   3120

ctctaaattg gatgtttctt tatatgacct tggaaactga agtgatctta gcattaaaca   3180

aaaatgcttt ttgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                            3277


<210>  2517
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  2517

Met Ala Ala Ser Ser Ser Ser Ser Ser Ala Gly Gly Val Ser Gly Ser 
1               5                   10                  15      


Ser Val Thr Gly Ser Gly Phe Ser Val Ser Asp Leu Ala Pro Pro Arg 
            20                  25                  30          


Lys Ala Leu Phe Thr Tyr Pro Lys Gly Ala Gly Glu Met Leu Glu Asp 
        35                  40                  45              


Gly Ser Glu Arg Phe Leu Cys Glu Ser Val Phe Ser Tyr Gln Val Ala 
    50                  55                  60                  


Ser Thr Leu Lys Gln Val Lys His Asp Gln Gln Val Ala Arg Met Glu 
65                  70                  75                  80  


Lys Leu Ala Gly Leu Val Glu Glu Leu Glu Ala Asp Glu Trp Arg Phe 
                85                  90                  95      


Lys Pro Ile Glu Gln Leu Leu Gly Phe Thr Pro Ser Ser Gly 
            100                 105                 110 


<210>  2518
<211>  1752
<212>  DNA
<213>  Homosapiens

<400>  2518
agggcgcagc aggccaaggg ggaggtgcga gcgtggacct gggacgggtc tgggcggctc     60

tcggtggttg gcacgggttc gcacacccat tcaagcggca ggacgcactt gtcttagcag    120

ttctcgctga ccgcgctagc tgcggcttct acgctccggc actctgagtt catcagcaaa    180

cgccctggcg tctgtcctca ccatgcctag cctttgggac cgcttctcgt cgtcgtccac    240

ctcctcttcg ccctcgtcct tgccccgaac tcccacccca gatcggccgc cgcgctcagc    300

ctgggggtcg gcgacccggg aggaggggtt tgaccgctcc acgagcctgg agagctcgga    360

ctgcgagtcc ctggacagca gcaacagtgg cttcgggccg gaggaagaca cggcttacct    420

ggatggggtg tcgttgcccg acttcgagct gctcagtgac cctgaggatg aacacttgtg    480

tgccaacctg atgcagctgc tgcaggagag cctggcccag gcgcggctgg gctctcgacg    540

ccctgcgcgc ctgctgatgc ctagccagtt ggtaagccag gtgggcaaag aactactgcg    600

cctggcctac agcgagccgt gcggcctgcg gggggcgctg ctggacgtct gcgtggagca    660

gggcaagagc tgccacagcg tgggccagct ggcactcgac cccagcctgg tgcccacctt    720

ccagctgacc ctcgtgctgc gcctggactc acgactctgg cccaagatcc aggggctgtt    780

tagctccgcc aactctccct tcctccctgg cttcagccag tccctgacgc tgagcactgg    840

cttccgagtc atcaagaaga agctgtacag ctcggaacag ctgctcattg aggagtgttg    900

aacttcaacc tgagggggcc gacagtgccc tccaagacag agacgactga acttttgggg    960

tggagactag aggcaggagc tgagggactg attcctgtgg ttggaaaact gaggcagcca   1020

cctaaggtgg aggtggggga atagtgtttc ccaggaagct cattgagttg tgtgcgggtg   1080

gctgtgcatt ggggacacat acccctcagt actgtagcat gaaacaaagg cttaggggcc   1140

aacaaggctt ccagctggat gtgtgtgtag catgtacctt attatttttg ttactgacag   1200

ttaacagtgg tgtgacatcc agagagcagc tgggctgctc ccgccccagc ccggcccagg   1260

gtgaaggaag aggcacgtgc tcctcagagc agccggaggg aggggggagg tcggaggtcg   1320

tggaggtggt ttgtgtatct tactggtctg aagggaccaa gtgtgtttgt tgtttgtttt   1380

gtatcttgtt tttctgatcg gagcatcact actgacctgt tgtaggcagc tatcttacag   1440

acgcatgaat gtaagagtag gaaggggtgg gtgtcaggga tcacttggga tctttgacac   1500

ttgaaaaatt acacctggca gctgcgttta agccttcccc catcgtgtac tgcagagttg   1560

agctggcagg ggaggggctg agagggtggg ggctggaacc cctccccggg aggagtgcca   1620

tctgggtctt ccatctagaa ctgtttacat gaagataaga tactcactgt tcatgaatac   1680

acttgatgtt caagtattaa gacctatgca atatttttta cttttctaat aaacatgttt   1740

gttaaaacag tt                                                       1752


<210>  2519
<211>  232
<212>  PRT
<213>  Homosapiens

<400>  2519

Met Pro Ser Leu Trp Asp Arg Phe Ser Ser Ser Ser Thr Ser Ser Ser 
1               5                   10                  15      


Pro Ser Ser Leu Pro Arg Thr Pro Thr Pro Asp Arg Pro Pro Arg Ser 
            20                  25                  30          


Ala Trp Gly Ser Ala Thr Arg Glu Glu Gly Phe Asp Arg Ser Thr Ser 
        35                  40                  45              


Leu Glu Ser Ser Asp Cys Glu Ser Leu Asp Ser Ser Asn Ser Gly Phe 
    50                  55                  60                  


Gly Pro Glu Glu Asp Thr Ala Tyr Leu Asp Gly Val Ser Leu Pro Asp 
65                  70                  75                  80  


Phe Glu Leu Leu Ser Asp Pro Glu Asp Glu His Leu Cys Ala Asn Leu 
                85                  90                  95      


Met Gln Leu Leu Gln Glu Ser Leu Ala Gln Ala Arg Leu Gly Ser Arg 
            100                 105                 110         


Arg Pro Ala Arg Leu Leu Met Pro Ser Gln Leu Val Ser Gln Val Gly 
        115                 120                 125             


Lys Glu Leu Leu Arg Leu Ala Tyr Ser Glu Pro Cys Gly Leu Arg Gly 
    130                 135                 140                 


Ala Leu Leu Asp Val Cys Val Glu Gln Gly Lys Ser Cys His Ser Val 
145                 150                 155                 160 


Gly Gln Leu Ala Leu Asp Pro Ser Leu Val Pro Thr Phe Gln Leu Thr 
                165                 170                 175     


Leu Val Leu Arg Leu Asp Ser Arg Leu Trp Pro Lys Ile Gln Gly Leu 
            180                 185                 190         


Phe Ser Ser Ala Asn Ser Pro Phe Leu Pro Gly Phe Ser Gln Ser Leu 
        195                 200                 205             


Thr Leu Ser Thr Gly Phe Arg Val Ile Lys Lys Lys Leu Tyr Ser Ser 
    210                 215                 220                 


Glu Gln Leu Leu Ile Glu Glu Cys 
225                 230         


<210>  2520
<211>  4342
<212>  DNA
<213>  Homosapiens

<400>  2520
aatctgggcg tgcaccatta ttgacaccta caccagccgt ccctttctta gaagacatac     60

ggtagcactt ccaccctcgc tcaaaactcg ggaaaggagg ggcggagggt ggatgtcatc    120

actccgcgcc cggctgcccg cgacgcgccg gcgggtggcg cagcccttcg ctcgcccggc    180

ctccccctcc ctggttccgc gttctggttc cgccatggaa tccaacaagg atgaagctga    240

gcgctgtatc agcatcgccc tcaaggccat ccagagcaac cagcccgacc gggcgctccg    300

cttcctggag aaggcacagc ggctgtatcc gacgccgcga gttcgcgccc tgattgagtc    360

cctcaaccag aaaccacaga ctgccggtga ccaaccccca cccacagaca caacccatgc    420

cacccacagg aaagcaggtg ggaccgatgc cccctcggcc aacggtgaag ctggaggaga    480

gagcaccaaa ggctacactg cagaacaggt tgcagctgtg aaaagggtca agcaatgtaa    540

agattactat gagatcctgg gggtgagcag aggggcctcg gatgaggacc tgaagaaggc    600

ctaccgcaga ctggccctca aattccaccc agacaagaac cacgcacctg gtgccactga    660

agccttcaaa gccattggca cagcatatgc ggtactcagc aacccggaga agaggaagca    720

gtatgaccag ttcggcgatg acaagagcca ggcggcccgg cacggccatg ggcatgggga    780

tttccaccgt ggctttgagg ccgacatctc ccctgaagac ctcttcaaca tgttctttgg    840

cggcggcttc ccttctagta acgtccacgt ctacagcaac ggccgcatgc gctataccta    900

ccagcaaagg caggaccgca gggacaacca gggtgatggc gggctagggg tgtttgtgca    960

gctgatgcct atcctcatcc tgattctcgt gtcagctctc agccagctca tggtctccag   1020

tccaccctac agtctgagtc caagaccgtc cgtgggccac atccacaggc gagtcactga   1080

ccacctgggt gtcgtctact atgtgggaga cactttctcc gaagagtaca caggctccag   1140

cctcaaaaca gtcgagcgga atgtggaaga tgattatatc gccaacctcc ggaacaactg   1200

ctggaaggag aagcagcaga aggaaggctt gctgtaccgg gcacgctact ttggcgacac   1260

agatatgtac cacagagcac agaagatggg cacccccagc tgcagccgac tgtcagaggt   1320

gcaggcctcc ctgcatggat agtcctgggc cagccacacc accgaggtcc aagtatgagc   1380

cagggctgcc tccaccctgc aactcctggc agctttggcc ctggtcatga gcagaggagg   1440

gagggggaga aagggaggaa gcctggtgat tgtggcaaag actcctgtcc ccagcctgac   1500

ctccagcctc cagagaccga gcagctgtgg ggcctgctgg gaaaccaagg tcggtttccg   1560

ccctctagcg atgctgtcct ccccactcct ccgctctgct ccctggctcc aggggtgtgg   1620

gggaccccag aaccaggcag agtgggaact tgaaactgtt gctgagggcc acccggggct   1680

tcttggtcca ctccagccat cagtcagcac ggccctttct ccagcacagc agactattgt   1740

ccgtgccctg gtatttaggc catcacatat ggtggggccc aagagagccc catatgcaca   1800

ctgcctgcct gataccagga agaaccatgt gggaataggt gggccaagag ccctcccctt   1860

tctccatccc tccagctagg aggaaatgga gcaagatgaa caggcagcca cgaggtgggt   1920

gggagctggc agtcttggtg gcggcagggg ccgcgggccc tgaccacccc cctctggtgg   1980

gatctgaggc actctctcga atgccgtcac acctggcagc ctggaagcca caggcatccg   2040

gccttgccca ggcatctcgc ctgcggtctg aggaagggaa cagaaggtca tgagttcagg   2100

gtcagacgca gccgctcagc acaggagggg tggaggggaa atgagagttg ctggtagcag   2160

gctccctcct tctgcagccc ggcgaatggg ggcgctgggc tctgttccca gcgtttgcca   2220

gaggtggcca cttcagccaa gcccggagaa gtgtgggcag aagcagtgaa ggttcttctc   2280

tgtgtgggtg ccctgcccac cccctccttt gcctgtgtcc tcccggcctg gatccatggc   2340

tgactctgcc tggaggccat ttgtgcctgc ctctgtgctg ccgcaggagg gcaggccgca   2400

agtggggttg gtgggggtcg agcgggcagc acggtgcagc ggtgcagtgg caaggggggc   2460

tacttgtgtg gcataagcta gaggagccgg tgccgcctga atgccgagct aactgttgcc   2520

actctcctcc ccagactatg aaatccctgg agaatttttg gtgacatgca ctgagccaag   2580

gtgatggact gtatatttga ggaaagacaa acaaagaaac aaaattaaaa tggaattgga   2640

ggccgaacgc tgcacagctg ccctctctct cacccagtaa atgcagaaag ctcttaggac   2700

agacagaaaa cctgccatgg ggctgcttcc ctccctcgca gggctggcgg aggctccgca   2760

tcgcctctct cctaggatac agaaaccatg gcaacgaaag tagaatgtaa aactcgcagc   2820

agatatcagt gggaagggct gggggagggg gcacccagct gcctttcctc cctcacagga   2880

gccaccacca gccacctctc aggagaagcc agaggccctg gccaaagata ggaggaagaa   2940

agagaactct ccatagaatg taatttatag atgcgtgtat atgtatatat atctatttat   3000

atgtaaatag gcatatatga agatatatat atatatagtc tactttttaa actctgcagg   3060

gatttggtta agttgttgag ctgatttctt ccatgtttta gaaaatgagg cctgtttggg   3120

gaaggtaccc tggtgatgtt tttgctagac attagctgta gctgacagca taaggagagt   3180

cgcatcagag cttttcacag ccccccgaaa ccccagcctg gttttgatgg cagcagtaat   3240

catgatagtg tgaacccgcg aaggcctcag gattatggtt aacctggaga ggagcaggcc   3300

atggaggcag gtgccaggtc agtattgagt cacagtagag gccccacaag gacctgcttg   3360

ggtgagacca cctctcccct ctcagcagcg ctggtgggct ctttgtcctg gtgcccagga   3420

gccctccagc cccctgccca cagaagggaa ggcctgcaga gggggccagg atctacctaa   3480

ccatttcccc acccctaagt ccctcagtgg gctttgcctt ataggtgcca cagggcacag   3540

ctccatcatt gccactggtt tttcctaagt catgcaccaa ggacttcaga aagttcttcc   3600

tccgagtcag tcagtggtgc cgggacccca gggcagcctc ctcgactcct gaagaaaagg   3660

cagtgcccgt ggctgcctct gtcttcactc gctgttgatg tgaccgccag gcctcctctc   3720

gtaccttgga caaaggatac acctgaacca gaatagtttt cttaccctca cattgaaatg   3780

aggattttgc ttaaaacagc acttgccgcc agtgggagga gggaggtttt atttattccc   3840

acagtttctc ctgggccttc tggaatgacc atgttttcct gtggcggtgg gtgtgtcatt   3900

gcgcccgccg tcttccaaag ccttacttcc ccaagctgcc agccaggagg tgataaccac   3960

cctcccagag tttctctcgg ctcttttttt aaaagtcccc caacaaatag gattcttgct   4020

gggaaaggaa gttcggtaag gaaatgtcaa atctggtttt taaacaaggt ccaaccctgc   4080

aatgaagcag ccacttcagc ccagagagat tataagaact gatgtggcca gagtgcctac   4140

ccactgtggc cccggtgctc tgcccccacg ccccgaccat ctggtcttgg tagatgtccc   4200

tagacgggct gagccatgtg caataagaac atagatccta aaggatcctc tggaagctgt   4260

atttcttgaa ttagaattct caaattgtac atctgttaat atatgtttat tatgtgactg   4320

gcaaaaaaaa aaaaaaaaaa aa                                            4342


<210>  2521
<211>  375
<212>  PRT
<213>  Homosapiens

<400>  2521

Met Glu Ser Asn Lys Asp Glu Ala Glu Arg Cys Ile Ser Ile Ala Leu 
1               5                   10                  15      


Lys Ala Ile Gln Ser Asn Gln Pro Asp Arg Ala Leu Arg Phe Leu Glu 
            20                  25                  30          


Lys Ala Gln Arg Leu Tyr Pro Thr Pro Arg Val Arg Ala Leu Ile Glu 
        35                  40                  45              


Ser Leu Asn Gln Lys Pro Gln Thr Ala Gly Asp Gln Pro Pro Pro Thr 
    50                  55                  60                  


Asp Thr Thr His Ala Thr His Arg Lys Ala Gly Gly Thr Asp Ala Pro 
65                  70                  75                  80  


Ser Ala Asn Gly Glu Ala Gly Gly Glu Ser Thr Lys Gly Tyr Thr Ala 
                85                  90                  95      


Glu Gln Val Ala Ala Val Lys Arg Val Lys Gln Cys Lys Asp Tyr Tyr 
            100                 105                 110         


Glu Ile Leu Gly Val Ser Arg Gly Ala Ser Asp Glu Asp Leu Lys Lys 
        115                 120                 125             


Ala Tyr Arg Arg Leu Ala Leu Lys Phe His Pro Asp Lys Asn His Ala 
    130                 135                 140                 


Pro Gly Ala Thr Glu Ala Phe Lys Ala Ile Gly Thr Ala Tyr Ala Val 
145                 150                 155                 160 


Leu Ser Asn Pro Glu Lys Arg Lys Gln Tyr Asp Gln Phe Gly Asp Asp 
                165                 170                 175     


Lys Ser Gln Ala Ala Arg His Gly His Gly His Gly Asp Phe His Arg 
            180                 185                 190         


Gly Phe Glu Ala Asp Ile Ser Pro Glu Asp Leu Phe Asn Met Phe Phe 
        195                 200                 205             


Gly Gly Gly Phe Pro Ser Ser Asn Val His Val Tyr Ser Asn Gly Arg 
    210                 215                 220                 


Met Arg Tyr Thr Tyr Gln Gln Arg Gln Asp Arg Arg Asp Asn Gln Gly 
225                 230                 235                 240 


Asp Gly Gly Leu Gly Val Phe Val Gln Leu Met Pro Ile Leu Ile Leu 
                245                 250                 255     


Ile Leu Val Ser Ala Leu Ser Gln Leu Met Val Ser Ser Pro Pro Tyr 
            260                 265                 270         


Ser Leu Ser Pro Arg Pro Ser Val Gly His Ile His Arg Arg Val Thr 
        275                 280                 285             


Asp His Leu Gly Val Val Tyr Tyr Val Gly Asp Thr Phe Ser Glu Glu 
    290                 295                 300                 


Tyr Thr Gly Ser Ser Leu Lys Thr Val Glu Arg Asn Val Glu Asp Asp 
305                 310                 315                 320 


Tyr Ile Ala Asn Leu Arg Asn Asn Cys Trp Lys Glu Lys Gln Gln Lys 
                325                 330                 335     


Glu Gly Leu Leu Tyr Arg Ala Arg Tyr Phe Gly Asp Thr Asp Met Tyr 
            340                 345                 350         


His Arg Ala Gln Lys Met Gly Thr Pro Ser Cys Ser Arg Leu Ser Glu 
        355                 360                 365             


Val Gln Ala Ser Leu His Gly 
    370                 375 


<210>  2522
<211>  3180
<212>  DNA
<213>  Homosapiens

<400>  2522
aatctgggcg tgcaccatta ttgacaccta caccagccgt ccctttctta gaagacatac     60

ggtagcactt ccaccctcgc tcaaaactcg ggaaaggagg ggcggagggt ggatgtcatc    120

actccgcgcc cggctgcccg cgacgcgccg gcgggtggcg cagcccttcg ctcgcccggc    180

ctccccctcc ctggttccgc gttctggttc cgccatggaa tccaacaagg atgaagctga    240

gcgctgtatc agcatcgccc tcaaggccat ccagagcaac cagcccgacc gggcgctccg    300

cttcctggag aaggcacagc ggctgtatcc gacgccgcga gttcgcgccc tgattgagtc    360

cctcaaccag aaaccacaga ctgccggtga ccaaccccca cccacagaca caacccatgc    420

cacccacagg aaagcaggtg ggaccgatgc cccctcggcc aacggtgaag ctggaggaga    480

gagcaccaaa ggctacactg cagaacaggt tgcagctgtg aaaagggtca agcaatgtaa    540

agattactat gagatcctgg gggtgagcag aggggcctcg gatgaggacc tgaagaaggc    600

ctaccgcaga ctggccctca aattccaccc agacaagaac cacgcacctg gtgccactga    660

agccttcaaa gccattggca cagcatatgc ggtactcagc aacccggaga agaggaagca    720

gtatgaccag ttcggcgatg acaagagcca ggcggcccgg cacggccatg ggcatgggga    780

tttccaccgt ggctttgagg ccgacatctc ccctgaagac ctcttcaaca tgttctttgg    840

cggcggcttc ccttctagta acgtccacgt ctacagcaac ggccgcatgc gctataccta    900

ccagcaaagg caggaccgca gggacaacca gggtgatggc gggctagggg tgtttgtgca    960

gctgatgcct atcctcatcc tgattctcgt gtcagctctc agccagctca tggtctccag   1020

tccaccctac agtctgagtc caagaccgtc cgtgggccac atccacaggc gagtcactga   1080

ccacctgggt gtcgtctact atgtgggaga cactttctcc gaagagtaca caggctccag   1140

cctcaaaaca gtcgagcgga atgtggaaga tgattatatc gccaacctcc ggaacaactg   1200

ctggaaggag aagcagcaga aggaaggctt gctgtaccgg gcacgctact ttggcgacac   1260

agatatgtac cacagagcac agaagatggg cacccccagc tgcagccgac tgtcagaggt   1320

gcaggcctcc ctgcatggat agtcctgggc cagccacacc accgaggtcc aaactatgaa   1380

atccctggag aatttttggt gacatgcact gagccaaggt gatggactgt atatttgagg   1440

aaagacaaac aaagaaacaa aattaaaatg gaattggagg ccgaacgctg cacagctgcc   1500

ctctctctca cccagtaaat gcagaaagct cttaggacag acagaaaacc tgccatgggg   1560

ctgcttccct ccctcgcagg gctggcggag gctccgcatc gcctctctcc taggatacag   1620

aaaccatggc aacgaaagta gaatgtaaaa ctcgcagcag atatcagtgg gaagggctgg   1680

gggagggggc acccagctgc ctttcctccc tcacaggagc caccaccagc cacctctcag   1740

gagaagccag aggccctggc caaagatagg aggaagaaag agaactctcc atagaatgta   1800

atttatagat gcgtgtatat gtatatatat ctatttatat gtaaataggc atatatgaag   1860

atatatatat atatagtcta ctttttaaac tctgcaggga tttggttaag ttgttgagct   1920

gatttcttcc atgttttaga aaatgaggcc tgtttgggga aggtaccctg gtgatgtttt   1980

tgctagacat tagctgtagc tgacagcata aggagagtcg catcagagct tttcacagcc   2040

ccccgaaacc ccagcctggt tttgatggca gcagtaatca tgatagtgtg aacccgcgaa   2100

ggcctcagga ttatggttaa cctggagagg agcaggccat ggaggcaggt gccaggtcag   2160

tattgagtca cagtagaggc cccacaagga cctgcttggg tgagaccacc tctcccctct   2220

cagcagcgct ggtgggctct ttgtcctggt gcccaggagc cctccagccc cctgcccaca   2280

gaagggaagg cctgcagagg gggccaggat ctacctaacc atttccccac ccctaagtcc   2340

ctcagtgggc tttgccttat aggtgccaca gggcacagct ccatcattgc cactggtttt   2400

tcctaagtca tgcaccaagg acttcagaaa gttcttcctc cgagtcagtc agtggtgccg   2460

ggaccccagg gcagcctcct cgactcctga agaaaaggca gtgcccgtgg ctgcctctgt   2520

cttcactcgc tgttgatgtg accgccaggc ctcctctcgt accttggaca aaggatacac   2580

ctgaaccaga atagttttct taccctcaca ttgaaatgag gattttgctt aaaacagcac   2640

ttgccgccag tgggaggagg gaggttttat ttattcccac agtttctcct gggccttctg   2700

gaatgaccat gttttcctgt ggcggtgggt gtgtcattgc gcccgccgtc ttccaaagcc   2760

ttacttcccc aagctgccag ccaggaggtg ataaccaccc tcccagagtt tctctcggct   2820

ctttttttaa aagtccccca acaaatagga ttcttgctgg gaaaggaagt tcggtaagga   2880

aatgtcaaat ctggttttta aacaaggtcc aaccctgcaa tgaagcagcc acttcagccc   2940

agagagatta taagaactga tgtggccaga gtgcctaccc actgtggccc cggtgctctg   3000

cccccacgcc ccgaccatct ggtcttggta gatgtcccta gacgggctga gccatgtgca   3060

ataagaacat agatcctaaa ggatcctctg gaagctgtat ttcttgaatt agaattctca   3120

aattgtacat ctgttaatat atgtttatta tgtgactggc aaaaaaaaaa aaaaaaaaaa   3180


<210>  2523
<211>  375
<212>  PRT
<213>  Homosapiens

<400>  2523

Met Glu Ser Asn Lys Asp Glu Ala Glu Arg Cys Ile Ser Ile Ala Leu 
1               5                   10                  15      


Lys Ala Ile Gln Ser Asn Gln Pro Asp Arg Ala Leu Arg Phe Leu Glu 
            20                  25                  30          


Lys Ala Gln Arg Leu Tyr Pro Thr Pro Arg Val Arg Ala Leu Ile Glu 
        35                  40                  45              


Ser Leu Asn Gln Lys Pro Gln Thr Ala Gly Asp Gln Pro Pro Pro Thr 
    50                  55                  60                  


Asp Thr Thr His Ala Thr His Arg Lys Ala Gly Gly Thr Asp Ala Pro 
65                  70                  75                  80  


Ser Ala Asn Gly Glu Ala Gly Gly Glu Ser Thr Lys Gly Tyr Thr Ala 
                85                  90                  95      


Glu Gln Val Ala Ala Val Lys Arg Val Lys Gln Cys Lys Asp Tyr Tyr 
            100                 105                 110         


Glu Ile Leu Gly Val Ser Arg Gly Ala Ser Asp Glu Asp Leu Lys Lys 
        115                 120                 125             


Ala Tyr Arg Arg Leu Ala Leu Lys Phe His Pro Asp Lys Asn His Ala 
    130                 135                 140                 


Pro Gly Ala Thr Glu Ala Phe Lys Ala Ile Gly Thr Ala Tyr Ala Val 
145                 150                 155                 160 


Leu Ser Asn Pro Glu Lys Arg Lys Gln Tyr Asp Gln Phe Gly Asp Asp 
                165                 170                 175     


Lys Ser Gln Ala Ala Arg His Gly His Gly His Gly Asp Phe His Arg 
            180                 185                 190         


Gly Phe Glu Ala Asp Ile Ser Pro Glu Asp Leu Phe Asn Met Phe Phe 
        195                 200                 205             


Gly Gly Gly Phe Pro Ser Ser Asn Val His Val Tyr Ser Asn Gly Arg 
    210                 215                 220                 


Met Arg Tyr Thr Tyr Gln Gln Arg Gln Asp Arg Arg Asp Asn Gln Gly 
225                 230                 235                 240 


Asp Gly Gly Leu Gly Val Phe Val Gln Leu Met Pro Ile Leu Ile Leu 
                245                 250                 255     


Ile Leu Val Ser Ala Leu Ser Gln Leu Met Val Ser Ser Pro Pro Tyr 
            260                 265                 270         


Ser Leu Ser Pro Arg Pro Ser Val Gly His Ile His Arg Arg Val Thr 
        275                 280                 285             


Asp His Leu Gly Val Val Tyr Tyr Val Gly Asp Thr Phe Ser Glu Glu 
    290                 295                 300                 


Tyr Thr Gly Ser Ser Leu Lys Thr Val Glu Arg Asn Val Glu Asp Asp 
305                 310                 315                 320 


Tyr Ile Ala Asn Leu Arg Asn Asn Cys Trp Lys Glu Lys Gln Gln Lys 
                325                 330                 335     


Glu Gly Leu Leu Tyr Arg Ala Arg Tyr Phe Gly Asp Thr Asp Met Tyr 
            340                 345                 350         


His Arg Ala Gln Lys Met Gly Thr Pro Ser Cys Ser Arg Leu Ser Glu 
        355                 360                 365             


Val Gln Ala Ser Leu His Gly 
    370                 375 


<210>  2524
<211>  2387
<212>  DNA
<213>  Homosapiens

<400>  2524
ggggtttcat ctctatggct gtcagaggtg ggcggctttg accgagaggc tgctggagct     60

cgtgtttgga cgcgatgttt cgtctgaact cactttctgc tttggcagaa ctggctgtgg    120

gttctcgatg gtaccatgga ggatcacagc ccatccagat ccggcgaaga ctaatgatgg    180

tggctttcct gggagcatct gcagtaactg caagtactgg tcttttgtgg aagggggccc    240

atgcagaatc tccaccatgt gtagacaacc taaaaagtga catcggtgat aaagggaaga    300

ataaagatga aggggatgtt tgtaaccatg agaaaaagac tgcagatctt gcccctcacc    360

cagaagagaa aaagaagaaa cgttctggat tcagagacag aaaagtgatg gaatatgaga    420

ataggattcg agcctactcc acgccagaca aaatcttccg atattttgcc accttgaaag    480

tcatcagtga gcctggtgaa gcagaagtgt ttatgacacc agaagatttt gtgcgatcca    540

taacacccaa tgaaaaacaa ccagaacact tgggtctgga tcaatatata ataaaacgct    600

ttgatggaaa gacagagaaa atttcccagg aacgagaaaa atttgctgat gaaggcagta    660

tattttacac ccttggagaa tgtgggctca tatccttttc agattacatt ttcctcacaa    720

ctgttctttc cactcctcag agaaattttg aaattgcctt caagatgttt gatttgaatg    780

gagatggaga agtagatatg gaagaatttg aacaggttca gagcatcatt cgctcccaaa    840

ccagtatggg tatgcgccac agagatcgtc caactactgg caacaccctc aagtctggct    900

tgtgttcagc cctcacaacc tacttttttg gagctgatct gaagggaaag ctgacaatca    960

aaaacttcct cgaatttcag cgtaaactgc agcatgatgt tctgaagctt gagtttgaac   1020

gccatgaccc tgtggatggg agaattactg agaggcagtt tggtggcatg ctacttgcct   1080

acagtggggt gcagtccaag aagctgaccg ccatgcagag gcagctcaag aagcacttca   1140

aagaaggaaa gggtctgaca tttcaggagg tggagaactt ctttactttc ctaaagaaca   1200

ttaatgatgt ggacactgca ttgagttttt accatatggc tggagcatct cttgataaag   1260

tgaccatgca gcaggtggcc aggacagtgg ctaaagtgga gctctcagac cacgtgtgtg   1320

atgtggtgtt tgcactcttt gactgtgatg gcaatggcga actgagcaat aaggaatttg   1380

tttccatcat gaagcaacgg ctgatgagag gcctggaaaa gcccaaagac atgggtttca   1440

ctcgcctcat gcaggccatg tggaaatgtg cacaggaaac tgcctgggac ttcgctttac   1500

ccaaacagta accccacact gcaagagggg acccctccac ccccagtacc ctggaccccc   1560

tccgcagagt ctcggcagag ccctttgtgc tgctgcttct ggaagtagtc tcccttcctc   1620

ccgggatgac ctcaggactc tgtcggtttc ccctctttac ccttccccgt ccccgtgttc   1680

tgctgggctc tgattctgcc caatgagtat ccccataggt tctcaaaaac atgaacaagt   1740

ctgtaaagct cagacatttg tcagcctcaa cagcaccacc cattcaagca tcctgtggat   1800

aaagaattca gggaaccatc cacacacctg ccaaccctgg gaagcatcca gttctcaaat   1860

cgtttttgct atggatttat actaacaaga acattccttg acttccctcc tgctggtgtt   1920

ttaaagccac aagtagggaa gatatctggc aggcagaaag aagtctgtga tgataaacaa   1980

tgatgaggat gacctaggca ccctacgcta gtgtgagaag cctgcgcccc aggaaggatc   2040

tgtgttagtc cctgggatgg ctccaaggcc tgctctagga aggcagcatg ctcagtggga   2100

acacagcaag attcagaatt taaagtagtt gcttcatggc tctgtgcact cccttttctt   2160

cctcgcagcc tccctaagat gactccagtg tgaccctgtg cttagtgagc aatagtgatt   2220

gagctcatgt tccctgcaag tgccatttcc tctccaggat gggcctctaa agctgaggcc   2280

tggctcagag cctgtttgcc ctctgtctta aacaattgta aatatcactt aaattataac   2340

catttgcaat aaacatcccc aaagttaaaa aaaaaaaaaa aaaaaaa                 2387


<210>  2525
<211>  478
<212>  PRT
<213>  Homosapiens

<400>  2525

Met Phe Arg Leu Asn Ser Leu Ser Ala Leu Ala Glu Leu Ala Val Gly 
1               5                   10                  15      


Ser Arg Trp Tyr His Gly Gly Ser Gln Pro Ile Gln Ile Arg Arg Arg 
            20                  25                  30          


Leu Met Met Val Ala Phe Leu Gly Ala Ser Ala Val Thr Ala Ser Thr 
        35                  40                  45              


Gly Leu Leu Trp Lys Gly Ala His Ala Glu Ser Pro Pro Cys Val Asp 
    50                  55                  60                  


Asn Leu Lys Ser Asp Ile Gly Asp Lys Gly Lys Asn Lys Asp Glu Gly 
65                  70                  75                  80  


Asp Val Cys Asn His Glu Lys Lys Thr Ala Asp Leu Ala Pro His Pro 
                85                  90                  95      


Glu Glu Lys Lys Lys Lys Arg Ser Gly Phe Arg Asp Arg Lys Val Met 
            100                 105                 110         


Glu Tyr Glu Asn Arg Ile Arg Ala Tyr Ser Thr Pro Asp Lys Ile Phe 
        115                 120                 125             


Arg Tyr Phe Ala Thr Leu Lys Val Ile Ser Glu Pro Gly Glu Ala Glu 
    130                 135                 140                 


Val Phe Met Thr Pro Glu Asp Phe Val Arg Ser Ile Thr Pro Asn Glu 
145                 150                 155                 160 


Lys Gln Pro Glu His Leu Gly Leu Asp Gln Tyr Ile Ile Lys Arg Phe 
                165                 170                 175     


Asp Gly Lys Thr Glu Lys Ile Ser Gln Glu Arg Glu Lys Phe Ala Asp 
            180                 185                 190         


Glu Gly Ser Ile Phe Tyr Thr Leu Gly Glu Cys Gly Leu Ile Ser Phe 
        195                 200                 205             


Ser Asp Tyr Ile Phe Leu Thr Thr Val Leu Ser Thr Pro Gln Arg Asn 
    210                 215                 220                 


Phe Glu Ile Ala Phe Lys Met Phe Asp Leu Asn Gly Asp Gly Glu Val 
225                 230                 235                 240 


Asp Met Glu Glu Phe Glu Gln Val Gln Ser Ile Ile Arg Ser Gln Thr 
                245                 250                 255     


Ser Met Gly Met Arg His Arg Asp Arg Pro Thr Thr Gly Asn Thr Leu 
            260                 265                 270         


Lys Ser Gly Leu Cys Ser Ala Leu Thr Thr Tyr Phe Phe Gly Ala Asp 
        275                 280                 285             


Leu Lys Gly Lys Leu Thr Ile Lys Asn Phe Leu Glu Phe Gln Arg Lys 
    290                 295                 300                 


Leu Gln His Asp Val Leu Lys Leu Glu Phe Glu Arg His Asp Pro Val 
305                 310                 315                 320 


Asp Gly Arg Ile Thr Glu Arg Gln Phe Gly Gly Met Leu Leu Ala Tyr 
                325                 330                 335     


Ser Gly Val Gln Ser Lys Lys Leu Thr Ala Met Gln Arg Gln Leu Lys 
            340                 345                 350         


Lys His Phe Lys Glu Gly Lys Gly Leu Thr Phe Gln Glu Val Glu Asn 
        355                 360                 365             


Phe Phe Thr Phe Leu Lys Asn Ile Asn Asp Val Asp Thr Ala Leu Ser 
    370                 375                 380                 


Phe Tyr His Met Ala Gly Ala Ser Leu Asp Lys Val Thr Met Gln Gln 
385                 390                 395                 400 


Val Ala Arg Thr Val Ala Lys Val Glu Leu Ser Asp His Val Cys Asp 
                405                 410                 415     


Val Val Phe Ala Leu Phe Asp Cys Asp Gly Asn Gly Glu Leu Ser Asn 
            420                 425                 430         


Lys Glu Phe Val Ser Ile Met Lys Gln Arg Leu Met Arg Gly Leu Glu 
        435                 440                 445             


Lys Pro Lys Asp Met Gly Phe Thr Arg Leu Met Gln Ala Met Trp Lys 
    450                 455                 460                 


Cys Ala Gln Glu Thr Ala Trp Asp Phe Ala Leu Pro Lys Gln 
465                 470                 475             


<210>  2526
<211>  2978
<212>  DNA
<213>  Homosapiens

<400>  2526
ggcggcgttt ccagttgaga gatggcggcc gccgcaggta gatcgctcct gctgctcctc     60

tcctctcggg gcggcggcgg cgggggcgcc ggcggctgcg gggcgctgac tgccggctgc    120

ttccctgggc tgggcgtcag ccgccaccgg cagcagcagc accaccggac ggtacaccag    180

aggatcgctt cctggcagaa tttgggagct gtttattgca gcactgttgt gccctctgat    240

gatgttacag tggtttatca aaatgggtta cctgtgatat ctgtgaggct accatcccgg    300

cgtgaacgct gtcagttcac actcaagcct atctctgact ctgttggtgt atttttacga    360

caactgcaag aagaggatcg gggaattgac agagttgcta tctattcacc agatggtgtt    420

cgcgttgctg cttcaacagg aatagacctc ctcctccttg atgactttaa gctggtcatt    480

aatgacttaa cataccacgt acgaccacca aaaagagacc tcttaagtca tgaaaatgca    540

gcaacgctga atgatgtaaa gacattggtc cagcaactat acaccacact gtgcattgag    600

cagcaccagt taaacaagga aagggagctt attgaaagac tagaggatct caaagagcag    660

ctggctcccc tggaaaaggt acgaattgag attagcagaa aagctgagaa gaggaccact    720

ttggtgctat ggggtggcct tgcctacatg gccacacagt ttggcatttt ggcccggctt    780

acctggtggg aatattcctg ggacatcatg gagccagtaa catacttcat cacttatgga    840

agtgccatgg caatgtatgc atattttgta atgacacgcc aggaatatgt ttatccagaa    900

gccagagaca gacaatactt actatttttc cataaaggag ccaaaaagtc acgttttgac    960

ctagagaaat acaatcaact caaggatgca attgctcagg cagaaatgga ccttaagaga   1020

ctgagagacc cattacaagt acatctgcct ctccgacaaa ttggtgaaaa agattgatct   1080

gcaaaaagcc tctgaatcct ggcagaagga acacctgttt gcctttttaa ttaaagcatt   1140

gcaggtggaa gctgggagcc atgtgggggg tagagcgttt ttacctttaa ttataaaaca   1200

aaaacagaaa ggatctgagg gaagaaggga atgttaaaac ctgaggatca ggcattgtgg   1260

aatataagct caaagggctt agtgaatatt gtcttaacca agtatctcag tttctggatg   1320

aaaatgatgc agttatatag ttgagagatt cataaagaga aaacaatgct gggggtgttc   1380

gtttcttgca tcttctttgc agagtcagca aaagagtaac acaccagcac cccactcgac   1440

tctatttgtt tttaatttaa ctgtccctat ttttgacata ggagtaaata aatatactag   1500

aaaagcaaat tctcatgata tgctaaaata tcattagcat ttattttaaa ttggacccag   1560

tctctgcaga gttaccagga atctttcctt ccagcatccc tttactgtcc acctacctgt   1620

acctcttggt tacactcatt ttttccattt gataattgga accaacttat aactgtttaa   1680

taattgacac tttagattat ctcttaatac cttcttaaat gtctatatat cccagtgctc   1740

tggatcagtg tctaaaaatc actggcaaca ctgcatgagg ttgttggttt tgttttgttt   1800

tattaattag tctttcacag gaggaataat tgccctcctt tatatactta tctattgata   1860

atcccctctc cctccagaac acaaatcaga gggaaagggg gtgttcagct gtactaccaa   1920

atcaggaaga tgtaaggttt acaaattggc taagaatcat ggctctgtag ccatttcaac   1980

cagaataatt ttattgctaa tctgctttgt gtgacagcat tccaggccag ccagatggga   2040

ctgccttgtc tggaggcttt gttcatctcg aaggacacac acttccacac tgtttgtgag   2100

ccctcccacc tccacaactt cagttgtaaa tcaagtgtgt ggatctcaaa gggtgcaatt   2160

tatctttata taggaataca tttctagggc ttccttcaag cccactctct tcaccctatt   2220

ttttcttatc ttaaattgag agaaagagaa ttaatcttat actttgtcaa aacattttct   2280

accatatttc cagatgacat ctgcgcttga agagtcaaag gaatctgtgt ctaatatcct   2340

gtttttaact gctgtagggg caggatggaa aggatgatgg gggctgccac accactgatt   2400

ggccttttct ttcacgtgat tcatccttcc tcattgtggc aaggagtttc tttctctttt   2460

tcttcctcct ttgggatcat tgtgtatgaa aagaaaaact ttaaatgaca aacccagact   2520

ccaggtgcct tgcaaaggtt gaaggccagc caggattgct gctgctgctg ctactcctgc   2580

caacacccct ttcattggca tgacggaatg aaaggatgca tgtctccact tcctgaccct   2640

ccgcccactt ccttctccct ccaccacccc cagtcgtcag ctccttccct catttatttt   2700

tgttaagttg tgtgaattat ttttaaccca tttatcctgt ttgtgcatag ggtttttaag   2760

aagaaacagc acagtgcaac gagcaaatct ttttggggtg tgtgggaagc aagggaggga   2820

ggacatggag aaaagttctt taaacaaata gcaaactatt gaacatgtgt aaaatcctgt   2880

atcatttatg aaatatgtat aaaaagcaat gtaccttctg gaacaataaa tacttattca   2940

atttttgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                           2978


<210>  2527
<211>  351
<212>  PRT
<213>  Homosapiens

<400>  2527

Met Ala Ala Ala Ala Gly Arg Ser Leu Leu Leu Leu Leu Ser Ser Arg 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Ala Gly Gly Cys Gly Ala Leu Thr Ala Gly 
            20                  25                  30          


Cys Phe Pro Gly Leu Gly Val Ser Arg His Arg Gln Gln Gln His His 
        35                  40                  45              


Arg Thr Val His Gln Arg Ile Ala Ser Trp Gln Asn Leu Gly Ala Val 
    50                  55                  60                  


Tyr Cys Ser Thr Val Val Pro Ser Asp Asp Val Thr Val Val Tyr Gln 
65                  70                  75                  80  


Asn Gly Leu Pro Val Ile Ser Val Arg Leu Pro Ser Arg Arg Glu Arg 
                85                  90                  95      


Cys Gln Phe Thr Leu Lys Pro Ile Ser Asp Ser Val Gly Val Phe Leu 
            100                 105                 110         


Arg Gln Leu Gln Glu Glu Asp Arg Gly Ile Asp Arg Val Ala Ile Tyr 
        115                 120                 125             


Ser Pro Asp Gly Val Arg Val Ala Ala Ser Thr Gly Ile Asp Leu Leu 
    130                 135                 140                 


Leu Leu Asp Asp Phe Lys Leu Val Ile Asn Asp Leu Thr Tyr His Val 
145                 150                 155                 160 


Arg Pro Pro Lys Arg Asp Leu Leu Ser His Glu Asn Ala Ala Thr Leu 
                165                 170                 175     


Asn Asp Val Lys Thr Leu Val Gln Gln Leu Tyr Thr Thr Leu Cys Ile 
            180                 185                 190         


Glu Gln His Gln Leu Asn Lys Glu Arg Glu Leu Ile Glu Arg Leu Glu 
        195                 200                 205             


Asp Leu Lys Glu Gln Leu Ala Pro Leu Glu Lys Val Arg Ile Glu Ile 
    210                 215                 220                 


Ser Arg Lys Ala Glu Lys Arg Thr Thr Leu Val Leu Trp Gly Gly Leu 
225                 230                 235                 240 


Ala Tyr Met Ala Thr Gln Phe Gly Ile Leu Ala Arg Leu Thr Trp Trp 
                245                 250                 255     


Glu Tyr Ser Trp Asp Ile Met Glu Pro Val Thr Tyr Phe Ile Thr Tyr 
            260                 265                 270         


Gly Ser Ala Met Ala Met Tyr Ala Tyr Phe Val Met Thr Arg Gln Glu 
        275                 280                 285             


Tyr Val Tyr Pro Glu Ala Arg Asp Arg Gln Tyr Leu Leu Phe Phe His 
    290                 295                 300                 


Lys Gly Ala Lys Lys Ser Arg Phe Asp Leu Glu Lys Tyr Asn Gln Leu 
305                 310                 315                 320 


Lys Asp Ala Ile Ala Gln Ala Glu Met Asp Leu Lys Arg Leu Arg Asp 
                325                 330                 335     


Pro Leu Gln Val His Leu Pro Leu Arg Gln Ile Gly Glu Lys Asp 
            340                 345                 350     


<210>  2528
<211>  2361
<212>  DNA
<213>  Homosapiens

<400>  2528
aaagcagtgc ttctctctgg ggccaaggcc agagctgtgg acaccttatc ccactcatcc     60

tcatcctctt cctctgataa agcccctacc agtgctgata aagtctttct cgtgagagcc    120

tagaggcctt aaaaaaaaaa gtgcttgaaa gagaagggga caaaggaaca ccagtattaa    180

gaggattttc cagtgtttct ggcagttggt ccagaaggat gcctccattc ctgcttctca    240

cctgcctctt catcacaggc acctccgtgt cacccgtggc cctagatcct tgttctgctt    300

acatcagcct gaatgagccc tggaggaaca ctgaccacca gttggatgag tctcaaggtc    360

ctcctctatg tgacaaccat gtgaatgggg agtggtacca cttcacgggc atggcgggag    420

atgccatgcc taccttctgc ataccagaaa accactgtgg aacccacgca cctgtctggc    480

tcaatggcag ccacccccta gaaggcgacg gcattgtgca acgccaggct tgtgccagct    540

tcaatgggaa ctgctgtctc tggaacacca cggtggaagt caaggcttgc cctggaggct    600

actatgtgta tcgtctgacc aagcccagcg tctgcttcca cgtctactgt ggtcattttt    660

atgacatctg cgacgaggac tgccatggca gctgctcaga taccagcgag tgcacatgcg    720

ctccaggaac tgtgctaggc cctgacaggc agacatgctt tgatgaaaat gaatgtgagc    780

aaaacaacgg tggctgcagt gagatctgtg tgaacctcaa aaactcctac cgctgtgagt    840

gtggggttgg ccgtgtgcta agaagtgatg gcaagacttg tgaagacgtt gaaggatgcc    900

acaataacaa tggtggctgc agccactctt gccttggatc tgagaaaggc taccagtgtg    960

aatgtccccg gggcctggtg ctgtctgagg ataaccacac ttgccaagtc cctgtgttgt   1020

gcaaatcaaa tgccattgaa gtgaacatcc ccagggagct ggttggtggc ctggagctct   1080

tcctgaccaa cacctcctgc cgaggagtgt ccaacggcac ccatgtcaac atcctcttct   1140

ctctcaagac atgtggtaca gtggtcgatg tggtgaatga caagattgtg gccagcaacc   1200

tcgtgacagg tctacccaag cagaccccgg ggagcagcgg ggacttcatc atccgaacca   1260

gcaagctgct gatcccggtg acctgcgagt ttccacgcct gtacaccatt tctgaaggat   1320

acgttcccaa ccttcgaaac tccccactgg aaatcatgag ccgaaatcat gggatcttcc   1380

cattcactct ggagatcttc aaggacaatg agtttgaaga gccttaccgg gaagctctgc   1440

ccaccctcaa gcttcgtgac tccctctact ttggcattga gcccgtggtg cacgtgagcg   1500

gcttggaaag cttggtggag agctgctttg ccacccccac ctccaagatc gacgaggtcc   1560

tgaaatacta cctcatccgg gatggctgtg tttcagatga ctcggtaaag cagtacacgt   1620

cccgggatca cctagcaaag cacttccagg tccctgtctt caagtttgtg ggcaaagacc   1680

acaaggaagt gtttctgcac tgccgggttc ttgtctgtgg agtgttggac gagcgttccc   1740

gctgtgccca gggttgccac cggcgaatgc gtcgtggggc aggaggagag gactcagccg   1800

gtctacaggg ccagacgcta acaggcggcc cgatccgcat cgactgggag gactagttcg   1860

tagccatacc tcgagtccct gcattggacg gctctgctct ttggagcttc tccccccacc   1920

gccctctaag aacatctgcc aacagctggg ttcagacttc acactgtgag ttcagactcc   1980

cagcaccaac tcactctgat cctggtccat tcagtgggca caggtcacag cactgctgaa   2040

caatgtggcc tgggtggggt ttcatctttc tagggttgaa aactaaactg tccacccaga   2100

aagacactca ccccatttcc ctcatttctt tcctacactt aaatacctcg tgtatggtgc   2160

aatcagacca caaaatcaga agctgggtat aatatttcaa gttacaaacc ctagaaaaat   2220

taaacagtta ctgaaattat gacttaaata cccaatgact ccttaaatat gtaaattata   2280

gttatacctt gaaatttcaa ttcaaatgca gactaattat agggaatttg gaagtgtatc   2340

aataaaacag tatataattt t                                             2361


<210>  2529
<211>  545
<212>  PRT
<213>  Homosapiens

<400>  2529

Met Pro Pro Phe Leu Leu Leu Thr Cys Leu Phe Ile Thr Gly Thr Ser 
1               5                   10                  15      


Val Ser Pro Val Ala Leu Asp Pro Cys Ser Ala Tyr Ile Ser Leu Asn 
            20                  25                  30          


Glu Pro Trp Arg Asn Thr Asp His Gln Leu Asp Glu Ser Gln Gly Pro 
        35                  40                  45              


Pro Leu Cys Asp Asn His Val Asn Gly Glu Trp Tyr His Phe Thr Gly 
    50                  55                  60                  


Met Ala Gly Asp Ala Met Pro Thr Phe Cys Ile Pro Glu Asn His Cys 
65                  70                  75                  80  


Gly Thr His Ala Pro Val Trp Leu Asn Gly Ser His Pro Leu Glu Gly 
                85                  90                  95      


Asp Gly Ile Val Gln Arg Gln Ala Cys Ala Ser Phe Asn Gly Asn Cys 
            100                 105                 110         


Cys Leu Trp Asn Thr Thr Val Glu Val Lys Ala Cys Pro Gly Gly Tyr 
        115                 120                 125             


Tyr Val Tyr Arg Leu Thr Lys Pro Ser Val Cys Phe His Val Tyr Cys 
    130                 135                 140                 


Gly His Phe Tyr Asp Ile Cys Asp Glu Asp Cys His Gly Ser Cys Ser 
145                 150                 155                 160 


Asp Thr Ser Glu Cys Thr Cys Ala Pro Gly Thr Val Leu Gly Pro Asp 
                165                 170                 175     


Arg Gln Thr Cys Phe Asp Glu Asn Glu Cys Glu Gln Asn Asn Gly Gly 
            180                 185                 190         


Cys Ser Glu Ile Cys Val Asn Leu Lys Asn Ser Tyr Arg Cys Glu Cys 
        195                 200                 205             


Gly Val Gly Arg Val Leu Arg Ser Asp Gly Lys Thr Cys Glu Asp Val 
    210                 215                 220                 


Glu Gly Cys His Asn Asn Asn Gly Gly Cys Ser His Ser Cys Leu Gly 
225                 230                 235                 240 


Ser Glu Lys Gly Tyr Gln Cys Glu Cys Pro Arg Gly Leu Val Leu Ser 
                245                 250                 255     


Glu Asp Asn His Thr Cys Gln Val Pro Val Leu Cys Lys Ser Asn Ala 
            260                 265                 270         


Ile Glu Val Asn Ile Pro Arg Glu Leu Val Gly Gly Leu Glu Leu Phe 
        275                 280                 285             


Leu Thr Asn Thr Ser Cys Arg Gly Val Ser Asn Gly Thr His Val Asn 
    290                 295                 300                 


Ile Leu Phe Ser Leu Lys Thr Cys Gly Thr Val Val Asp Val Val Asn 
305                 310                 315                 320 


Asp Lys Ile Val Ala Ser Asn Leu Val Thr Gly Leu Pro Lys Gln Thr 
                325                 330                 335     


Pro Gly Ser Ser Gly Asp Phe Ile Ile Arg Thr Ser Lys Leu Leu Ile 
            340                 345                 350         


Pro Val Thr Cys Glu Phe Pro Arg Leu Tyr Thr Ile Ser Glu Gly Tyr 
        355                 360                 365             


Val Pro Asn Leu Arg Asn Ser Pro Leu Glu Ile Met Ser Arg Asn His 
    370                 375                 380                 


Gly Ile Phe Pro Phe Thr Leu Glu Ile Phe Lys Asp Asn Glu Phe Glu 
385                 390                 395                 400 


Glu Pro Tyr Arg Glu Ala Leu Pro Thr Leu Lys Leu Arg Asp Ser Leu 
                405                 410                 415     


Tyr Phe Gly Ile Glu Pro Val Val His Val Ser Gly Leu Glu Ser Leu 
            420                 425                 430         


Val Glu Ser Cys Phe Ala Thr Pro Thr Ser Lys Ile Asp Glu Val Leu 
        435                 440                 445             


Lys Tyr Tyr Leu Ile Arg Asp Gly Cys Val Ser Asp Asp Ser Val Lys 
    450                 455                 460                 


Gln Tyr Thr Ser Arg Asp His Leu Ala Lys His Phe Gln Val Pro Val 
465                 470                 475                 480 


Phe Lys Phe Val Gly Lys Asp His Lys Glu Val Phe Leu His Cys Arg 
                485                 490                 495     


Val Leu Val Cys Gly Val Leu Asp Glu Arg Ser Arg Cys Ala Gln Gly 
            500                 505                 510         


Cys His Arg Arg Met Arg Arg Gly Ala Gly Gly Glu Asp Ser Ala Gly 
        515                 520                 525             


Leu Gln Gly Gln Thr Leu Thr Gly Gly Pro Ile Arg Ile Asp Trp Glu 
    530                 535                 540                 


Asp 
545 


<210>  2530
<211>  1092
<212>  DNA
<213>  Homosapiens

<400>  2530
tgtccctgga attctgggac actggctggg gtttgaggag agaagccagt acctacctgg     60

ctgcaggatg aagctggcca gtggcttctt ggttttgtgg ctcagccttg ggggtggcct    120

ggctcagagc gacacgagcc ctgacacgga ggagtcctat tcagactggg gccttcggca    180

cctccgggga agctttgaat ccgtcaatag ctacttcgat tcttttctgg agctgctggg    240

agggaagaat ggagtctgtc agtacaggtg ccgatatgga aaggcaccaa tgcccagacc    300

tggctacaag ccccaagagc ccaatggctg cggctcctat ttcctgggtc tcaaggtacc    360

agaaagtatg gacttgggca ttccagcaat gacaaagtgc tgcaaccagc tggatgtctg    420

ttatgacact tgcggtgcca acaaatatcg ctgtgatgca aaattccgat ggtgtctcca    480

ctcgatctgc tctgacctta agcggagtct gggctttgtc tccaaagtgg aagcagcctg    540

tgattccctg gttgacactg tgttcaacac cgtgtggacc ttgggctgcc gcccctttat    600

gaatagtcag cgggcagctt gcatctgtgc agaggaggag aaggaagagt tatgaggaag    660

aagtgattcc ttcctggttt tgagtgacac cacagctgtc agccttcaag atgtcaagtc    720

ttcgagtcag cgtgactcat tcattcttcc aacagtttgg acaccacaaa gcaggagaaa    780

gggaacattt ttctacagct ggaaagtgag tcctatcctt tgaggaaatt tgaaaaaaga    840

catggagtgg tttgaaagct actcttcatt taagactgct ctccccaacc aagacacatt    900

tgcctggaaa ttcagttctt agcttaaaga ctaaaatgca agcaaaccct gcaattcctg    960

gacctgatag ttatattcat gagtgaaatt gtggggagtc cagccatttg ggaggcaatg   1020

actttctgct ggcccatgtt tcagttgcca gtaagcttct cacatttaat aaagtgtact   1080

ttttagaaca tt                                                       1092


<210>  2531
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  2531

Met Lys Leu Ala Ser Gly Phe Leu Val Leu Trp Leu Ser Leu Gly Gly 
1               5                   10                  15      


Gly Leu Ala Gln Ser Asp Thr Ser Pro Asp Thr Glu Glu Ser Tyr Ser 
            20                  25                  30          


Asp Trp Gly Leu Arg His Leu Arg Gly Ser Phe Glu Ser Val Asn Ser 
        35                  40                  45              


Tyr Phe Asp Ser Phe Leu Glu Leu Leu Gly Gly Lys Asn Gly Val Cys 
    50                  55                  60                  


Gln Tyr Arg Cys Arg Tyr Gly Lys Ala Pro Met Pro Arg Pro Gly Tyr 
65                  70                  75                  80  


Lys Pro Gln Glu Pro Asn Gly Cys Gly Ser Tyr Phe Leu Gly Leu Lys 
                85                  90                  95      


Val Pro Glu Ser Met Asp Leu Gly Ile Pro Ala Met Thr Lys Cys Cys 
            100                 105                 110         


Asn Gln Leu Asp Val Cys Tyr Asp Thr Cys Gly Ala Asn Lys Tyr Arg 
        115                 120                 125             


Cys Asp Ala Lys Phe Arg Trp Cys Leu His Ser Ile Cys Ser Asp Leu 
    130                 135                 140                 


Lys Arg Ser Leu Gly Phe Val Ser Lys Val Glu Ala Ala Cys Asp Ser 
145                 150                 155                 160 


Leu Val Asp Thr Val Phe Asn Thr Val Trp Thr Leu Gly Cys Arg Pro 
                165                 170                 175     


Phe Met Asn Ser Gln Arg Ala Ala Cys Ile Cys Ala Glu Glu Glu Lys 
            180                 185                 190         


Glu Glu Leu 
        195 


<210>  2532
<211>  2752
<212>  DNA
<213>  Homosapiens

<400>  2532
gcccagtcgc gccgccagcg ggctgagggt aggaagtagc cgctccgagt ggaggcgact     60

gggggctgaa gagcgcgccg ccctctcgtc ccactttcca ggtgtgtgat cctgtaaaat    120

taaatcttcc aagatgatct ggtatatatt aattatagga attctgcttc cccagtcttt    180

ggctcatcca ggctttttta cttcaattgg tcagatgact gatttgatcc atactgagaa    240

agatctggtg acttctctga aagattatat taaggcagaa gaggacaagt tagaacaaat    300

aaaaaaatgg gcagagaagt tagatcggct aactagtaca gcgacaaaag atccagaagg    360

atttgttggg catccagtaa atgcattcaa attaatgaaa cgtctgaata ctgagtggag    420

tgagttggag aatctggtcc ttaaggatat gtcagatggc tttatctcta acctaaccat    480

tcagagacag tactttccta atgatgaaga tcaggttggg gcagccaaag ctctgttacg    540

tctccaggat acctacaatt tggatacaga taccatctca aagggtaatc ttccaggagt    600

gaaacacaaa tcttttctaa cggctgagga ctgctttgag ttgggcaaag tggcctatac    660

agaagcagat tattaccata cggaactgtg gatggaacaa gccctaaggc aactggatga    720

aggcgagatt tctaccatag ataaagtctc tgttctagat tatttgagct atgcggtata    780

tcagcaggga gacctggata aggcactttt gctcacaaag aagcttcttg aactagatcc    840

tgaacatcag agagctaatg gtaacttaaa atattttgag tatataatgg ctaaagaaaa    900

agatgtcaat aagtctgctt cagatgacca atctgatcag aaaactacac caaagaaaaa    960

aggggttgct gtggattacc tgccagagag acagaagtac gaaatgctgt gccgtgggga   1020

gggtatcaaa atgacccctc ggagacagaa aaaactcttt tgccgctacc atgatggaaa   1080

ccgtaatcct aaatttattc tggctccagc taaacaggag gatgaatggg acaagcctcg   1140

tattattcgc ttccatgata ttatttctga tgcagaaatt gaaatcgtca aagacctagc   1200

aaaaccaagg ctgagccgag ctacagtaca tgaccctgag actggaaaat tgaccacagc   1260

acagtacaga gtatctaaga gtgcctggct ctctggctat gaaaatcctg tggtgtctcg   1320

aattaatatg agaatacaag atctaacagg actagatgtt tccacagcag aggaattaca   1380

ggtagcaaat tatggagttg gaggacagta tgaaccccat tttgactttg cacggaaaga   1440

tgagccagat gctttcaaag agctggggac aggaaataga attgctacat ggctgtttta   1500

tatgagtgat gtgtctgcag gaggagccac tgtttttcct gaagttggag ctagtgtttg   1560

gcccaaaaaa ggaactgctg ttttctggta taatctgttt gccagtggag aaggagatta   1620

tagtacacgg catgcagcct gtccagtgct agttggcaac aaatgggtat ccaataaatg   1680

gctccatgaa cgtggacaag aatttcgaag accttgtacg ttgtcagaat tggaatgaca   1740

aacaggcttc cctttttctc ctattgttgt actcttatgt gtctgatata cacatttcct   1800

agtcttaact ttcaggagtt tacaattgac taacactcca tgattgattc agtcatgaac   1860

ctcatcccat gtttcatctg tggacaattg cttactttgt gggttctttt aaaagtaaca   1920

cgaaatcatc atattgcata aaaccttaaa gttctgttgg tatcacagaa gacaaggcag   1980

agtttaaagt gaggaatttt atatttaaag aactttttgg ttggataaaa acataatttg   2040

agcatccagt tttagtattt cactacatct cagttggtgg gtgttaagct agaatgggct   2100

gtgtgatagg aaacaaatgc cttacagatg tgcctaggtg ttctgtttac ctagtgtctt   2160

actctgtttt ctggatctga agactagtaa taaactagga cactaactgg gttccatgtg   2220

attgcccttt catatgatct tctaagttga tttttttcct cccaagtctt ttttaaagaa   2280

agtatactgt attttaccaa ccccctctct tttcttttag ctcctctgtg gtgaattaaa   2340

cgtacttgag ttaaaatatt tcgatttttt tttttttttt aatggaaagt cctgcataac   2400

aacactgggc cttcttaact aaaatgctca ccacttagcc tgttttttta tccctttttt   2460

aaaatgacag atgattttgt tcaggaattt tgctgttttt cttagtgcta ataccttgcc   2520

tcttattcct gctacagcag ggtggtaata ttggcattct gattaaatac tgtgccttag   2580

gagactggaa gtttaaaaat gtacaagtcc tttcagtgat gagggaattg atttttttta   2640

aaagtctttt tcttagaaag ccaaaatgtt tgttttttta agattctgaa atgtgttgtg   2700

acaacaatga cctatttatg atcttaaatc ttttttaaaa aaaaaaaaaa aa           2752


<210>  2533
<211>  534
<212>  PRT
<213>  Homosapiens

<400>  2533

Met Ile Trp Tyr Ile Leu Ile Ile Gly Ile Leu Leu Pro Gln Ser Leu 
1               5                   10                  15      


Ala His Pro Gly Phe Phe Thr Ser Ile Gly Gln Met Thr Asp Leu Ile 
            20                  25                  30          


His Thr Glu Lys Asp Leu Val Thr Ser Leu Lys Asp Tyr Ile Lys Ala 
        35                  40                  45              


Glu Glu Asp Lys Leu Glu Gln Ile Lys Lys Trp Ala Glu Lys Leu Asp 
    50                  55                  60                  


Arg Leu Thr Ser Thr Ala Thr Lys Asp Pro Glu Gly Phe Val Gly His 
65                  70                  75                  80  


Pro Val Asn Ala Phe Lys Leu Met Lys Arg Leu Asn Thr Glu Trp Ser 
                85                  90                  95      


Glu Leu Glu Asn Leu Val Leu Lys Asp Met Ser Asp Gly Phe Ile Ser 
            100                 105                 110         


Asn Leu Thr Ile Gln Arg Gln Tyr Phe Pro Asn Asp Glu Asp Gln Val 
        115                 120                 125             


Gly Ala Ala Lys Ala Leu Leu Arg Leu Gln Asp Thr Tyr Asn Leu Asp 
    130                 135                 140                 


Thr Asp Thr Ile Ser Lys Gly Asn Leu Pro Gly Val Lys His Lys Ser 
145                 150                 155                 160 


Phe Leu Thr Ala Glu Asp Cys Phe Glu Leu Gly Lys Val Ala Tyr Thr 
                165                 170                 175     


Glu Ala Asp Tyr Tyr His Thr Glu Leu Trp Met Glu Gln Ala Leu Arg 
            180                 185                 190         


Gln Leu Asp Glu Gly Glu Ile Ser Thr Ile Asp Lys Val Ser Val Leu 
        195                 200                 205             


Asp Tyr Leu Ser Tyr Ala Val Tyr Gln Gln Gly Asp Leu Asp Lys Ala 
    210                 215                 220                 


Leu Leu Leu Thr Lys Lys Leu Leu Glu Leu Asp Pro Glu His Gln Arg 
225                 230                 235                 240 


Ala Asn Gly Asn Leu Lys Tyr Phe Glu Tyr Ile Met Ala Lys Glu Lys 
                245                 250                 255     


Asp Val Asn Lys Ser Ala Ser Asp Asp Gln Ser Asp Gln Lys Thr Thr 
            260                 265                 270         


Pro Lys Lys Lys Gly Val Ala Val Asp Tyr Leu Pro Glu Arg Gln Lys 
        275                 280                 285             


Tyr Glu Met Leu Cys Arg Gly Glu Gly Ile Lys Met Thr Pro Arg Arg 
    290                 295                 300                 


Gln Lys Lys Leu Phe Cys Arg Tyr His Asp Gly Asn Arg Asn Pro Lys 
305                 310                 315                 320 


Phe Ile Leu Ala Pro Ala Lys Gln Glu Asp Glu Trp Asp Lys Pro Arg 
                325                 330                 335     


Ile Ile Arg Phe His Asp Ile Ile Ser Asp Ala Glu Ile Glu Ile Val 
            340                 345                 350         


Lys Asp Leu Ala Lys Pro Arg Leu Ser Arg Ala Thr Val His Asp Pro 
        355                 360                 365             


Glu Thr Gly Lys Leu Thr Thr Ala Gln Tyr Arg Val Ser Lys Ser Ala 
    370                 375                 380                 


Trp Leu Ser Gly Tyr Glu Asn Pro Val Val Ser Arg Ile Asn Met Arg 
385                 390                 395                 400 


Ile Gln Asp Leu Thr Gly Leu Asp Val Ser Thr Ala Glu Glu Leu Gln 
                405                 410                 415     


Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp Phe 
            420                 425                 430         


Ala Arg Lys Asp Glu Pro Asp Ala Phe Lys Glu Leu Gly Thr Gly Asn 
        435                 440                 445             


Arg Ile Ala Thr Trp Leu Phe Tyr Met Ser Asp Val Ser Ala Gly Gly 
    450                 455                 460                 


Ala Thr Val Phe Pro Glu Val Gly Ala Ser Val Trp Pro Lys Lys Gly 
465                 470                 475                 480 


Thr Ala Val Phe Trp Tyr Asn Leu Phe Ala Ser Gly Glu Gly Asp Tyr 
                485                 490                 495     


Ser Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Asn Lys Trp Val 
            500                 505                 510         


Ser Asn Lys Trp Leu His Glu Arg Gly Gln Glu Phe Arg Arg Pro Cys 
        515                 520                 525             


Thr Leu Ser Glu Leu Glu 
    530                 


<210>  2534
<211>  2752
<212>  DNA
<213>  Homosapiens

<400>  2534
gcccagtcgc gccgccagcg ggctgagggt aggaagtagc cgctccgagt ggaggcgact     60

gggggctgaa gagcgcgccg ccctctcgtc ccactttcca ggtgtgtgat cctgtaaaat    120

taaatcttcc aagatgatct ggtatatatt aattatagga attctgcttc cccagtcttt    180

ggctcatcca ggctttttta cttcaattgg tcagatgact gatttgatcc atactgagaa    240

agatctggtg acttctctga aagattatat taaggcagaa gaggacaagt tagaacaaat    300

aaaaaaatgg gcagagaagt tagatcggct aactagtaca gcgacaaaag atccagaagg    360

atttgttggg catccagtaa atgcattcaa attaatgaaa cgtctgaata ctgagtggag    420

tgagttggag aatctggtcc ttaaggatat gtcagatggc tttatctcta acctaaccat    480

tcagagacag tactttccta atgatgaaga tcaggttggg gcagccaaag ctctgttacg    540

tctccaggat acctacaatt tggatacaga taccatctca aagggtaatc ttccaggagt    600

gaaacacaaa tcttttctaa cggctgagga ctgctttgag ttgggcaaag tggcctatac    660

agaagcagat tattaccata cggaactgtg gatggaacaa gccctaaggc aactggatga    720

aggcgagatt tctaccatag ataaagtctc tgttctagat tatttgagct atgcggtata    780

tcagcaggga gacctggata aggcactttt gctcacaaag aagcttcttg aactagatcc    840

tgaacatcag agagctaatg gtaacttaaa atattttgag tatataatgg ctaaagaaaa    900

agatgtcaat aagtctgctt cagatgacca atctgatcag aaaactacac caaagaaaaa    960

aggggttgct gtggattacc tgccagagag acagaagtac gaaatgctgt gccgtgggga   1020

gggtatcaaa atgacccctc ggagacagaa aaaactcttt tgccgctacc atgatggaaa   1080

ccgtaatcct aaatttattc tggctccagc taaacaggag gatgaatggg acaagcctcg   1140

tattattcgc ttccatgata ttatttctga tgcagaaatt gaaatcgtca aagacctagc   1200

aaaaccaagg ctgaggcgag ccaccatttc aaacccaata acaggagact tggagacggt   1260

acattacaga attagcaaaa gtgcctggct ctctggctat gaaaatcctg tggtgtctcg   1320

aattaatatg agaatacaag atctaacagg actagatgtt tccacagcag aggaattaca   1380

ggtagcaaat tatggagttg gaggacagta tgaaccccat tttgactttg cacggaaaga   1440

tgagccagat gctttcaaag agctggggac aggaaataga attgctacat ggctgtttta   1500

tatgagtgat gtgtctgcag gaggagccac tgtttttcct gaagttggag ctagtgtttg   1560

gcccaaaaaa ggaactgctg ttttctggta taatctgttt gccagtggag aaggagatta   1620

tagtacacgg catgcagcct gtccagtgct agttggcaac aaatgggtat ccaataaatg   1680

gctccatgaa cgtggacaag aatttcgaag accttgtacg ttgtcagaat tggaatgaca   1740

aacaggcttc cctttttctc ctattgttgt actcttatgt gtctgatata cacatttcct   1800

agtcttaact ttcaggagtt tacaattgac taacactcca tgattgattc agtcatgaac   1860

ctcatcccat gtttcatctg tggacaattg cttactttgt gggttctttt aaaagtaaca   1920

cgaaatcatc atattgcata aaaccttaaa gttctgttgg tatcacagaa gacaaggcag   1980

agtttaaagt gaggaatttt atatttaaag aactttttgg ttggataaaa acataatttg   2040

agcatccagt tttagtattt cactacatct cagttggtgg gtgttaagct agaatgggct   2100

gtgtgatagg aaacaaatgc cttacagatg tgcctaggtg ttctgtttac ctagtgtctt   2160

actctgtttt ctggatctga agactagtaa taaactagga cactaactgg gttccatgtg   2220

attgcccttt catatgatct tctaagttga tttttttcct cccaagtctt ttttaaagaa   2280

agtatactgt attttaccaa ccccctctct tttcttttag ctcctctgtg gtgaattaaa   2340

cgtacttgag ttaaaatatt tcgatttttt tttttttttt aatggaaagt cctgcataac   2400

aacactgggc cttcttaact aaaatgctca ccacttagcc tgttttttta tccctttttt   2460

aaaatgacag atgattttgt tcaggaattt tgctgttttt cttagtgcta ataccttgcc   2520

tcttattcct gctacagcag ggtggtaata ttggcattct gattaaatac tgtgccttag   2580

gagactggaa gtttaaaaat gtacaagtcc tttcagtgat gagggaattg atttttttta   2640

aaagtctttt tcttagaaag ccaaaatgtt tgttttttta agattctgaa atgtgttgtg   2700

acaacaatga cctatttatg atcttaaatc ttttttaaaa aaaaaaaaaa aa           2752


<210>  2535
<211>  534
<212>  PRT
<213>  Homosapiens

<400>  2535

Met Ile Trp Tyr Ile Leu Ile Ile Gly Ile Leu Leu Pro Gln Ser Leu 
1               5                   10                  15      


Ala His Pro Gly Phe Phe Thr Ser Ile Gly Gln Met Thr Asp Leu Ile 
            20                  25                  30          


His Thr Glu Lys Asp Leu Val Thr Ser Leu Lys Asp Tyr Ile Lys Ala 
        35                  40                  45              


Glu Glu Asp Lys Leu Glu Gln Ile Lys Lys Trp Ala Glu Lys Leu Asp 
    50                  55                  60                  


Arg Leu Thr Ser Thr Ala Thr Lys Asp Pro Glu Gly Phe Val Gly His 
65                  70                  75                  80  


Pro Val Asn Ala Phe Lys Leu Met Lys Arg Leu Asn Thr Glu Trp Ser 
                85                  90                  95      


Glu Leu Glu Asn Leu Val Leu Lys Asp Met Ser Asp Gly Phe Ile Ser 
            100                 105                 110         


Asn Leu Thr Ile Gln Arg Gln Tyr Phe Pro Asn Asp Glu Asp Gln Val 
        115                 120                 125             


Gly Ala Ala Lys Ala Leu Leu Arg Leu Gln Asp Thr Tyr Asn Leu Asp 
    130                 135                 140                 


Thr Asp Thr Ile Ser Lys Gly Asn Leu Pro Gly Val Lys His Lys Ser 
145                 150                 155                 160 


Phe Leu Thr Ala Glu Asp Cys Phe Glu Leu Gly Lys Val Ala Tyr Thr 
                165                 170                 175     


Glu Ala Asp Tyr Tyr His Thr Glu Leu Trp Met Glu Gln Ala Leu Arg 
            180                 185                 190         


Gln Leu Asp Glu Gly Glu Ile Ser Thr Ile Asp Lys Val Ser Val Leu 
        195                 200                 205             


Asp Tyr Leu Ser Tyr Ala Val Tyr Gln Gln Gly Asp Leu Asp Lys Ala 
    210                 215                 220                 


Leu Leu Leu Thr Lys Lys Leu Leu Glu Leu Asp Pro Glu His Gln Arg 
225                 230                 235                 240 


Ala Asn Gly Asn Leu Lys Tyr Phe Glu Tyr Ile Met Ala Lys Glu Lys 
                245                 250                 255     


Asp Val Asn Lys Ser Ala Ser Asp Asp Gln Ser Asp Gln Lys Thr Thr 
            260                 265                 270         


Pro Lys Lys Lys Gly Val Ala Val Asp Tyr Leu Pro Glu Arg Gln Lys 
        275                 280                 285             


Tyr Glu Met Leu Cys Arg Gly Glu Gly Ile Lys Met Thr Pro Arg Arg 
    290                 295                 300                 


Gln Lys Lys Leu Phe Cys Arg Tyr His Asp Gly Asn Arg Asn Pro Lys 
305                 310                 315                 320 


Phe Ile Leu Ala Pro Ala Lys Gln Glu Asp Glu Trp Asp Lys Pro Arg 
                325                 330                 335     


Ile Ile Arg Phe His Asp Ile Ile Ser Asp Ala Glu Ile Glu Ile Val 
            340                 345                 350         


Lys Asp Leu Ala Lys Pro Arg Leu Arg Arg Ala Thr Ile Ser Asn Pro 
        355                 360                 365             


Ile Thr Gly Asp Leu Glu Thr Val His Tyr Arg Ile Ser Lys Ser Ala 
    370                 375                 380                 


Trp Leu Ser Gly Tyr Glu Asn Pro Val Val Ser Arg Ile Asn Met Arg 
385                 390                 395                 400 


Ile Gln Asp Leu Thr Gly Leu Asp Val Ser Thr Ala Glu Glu Leu Gln 
                405                 410                 415     


Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp Phe 
            420                 425                 430         


Ala Arg Lys Asp Glu Pro Asp Ala Phe Lys Glu Leu Gly Thr Gly Asn 
        435                 440                 445             


Arg Ile Ala Thr Trp Leu Phe Tyr Met Ser Asp Val Ser Ala Gly Gly 
    450                 455                 460                 


Ala Thr Val Phe Pro Glu Val Gly Ala Ser Val Trp Pro Lys Lys Gly 
465                 470                 475                 480 


Thr Ala Val Phe Trp Tyr Asn Leu Phe Ala Ser Gly Glu Gly Asp Tyr 
                485                 490                 495     


Ser Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Asn Lys Trp Val 
            500                 505                 510         


Ser Asn Lys Trp Leu His Glu Arg Gly Gln Glu Phe Arg Arg Pro Cys 
        515                 520                 525             


Thr Leu Ser Glu Leu Glu 
    530                 


<210>  2536
<211>  2120
<212>  DNA
<213>  Homosapiens

<400>  2536
ggcagaagca gcaatggtcc ctccagggaa cggaagccgt tgaacgtgaa catttggagt     60

ttcctctttt gtgctgattc ctgaggacta ggaaggtgcc ccgaaaagaa ttcagagacc    120

tgacaatgtc cctgtattgt ggaatagctt gcaggagaaa atttttttgg tgctataggc    180

tgctgtcaac ctatgttact aagacacggt atttatttga actgaaggaa gatgatgatg    240

catgtaaaaa agcccagcaa acaggagcgt tttacctctt tcatagtctg gctcctctgc    300

ttcagacttc agcacatcaa tacctggccc cccggcacag cctgttagag ttggaaaggc    360

tcctgggtaa atttggacag gatgcacaaa gaatagaaga ttctgtgctg attggatgct    420

ctgagcagca ggaagcatgg tttgctctgg atctaggtct ggatagctcc ttttccataa    480

gtgcctcctt acacaaacct gaaatggaga cagagctcaa ggggtctttc attgagctga    540

gaaaggcact ctttcaactc aatgcaaggg atgcctcctt gctgtccacg gctcaagctc    600

ttctccgctg gcatgatgct catcagttct gcagcagaag tgggcagccc accaagaaga    660

acgtggctgg cagcaagcgt gtgtgccctt ccaataatat aatctattat ccacagatgg    720

ctcctgtggc gatcacgctg gtgtcagatg ggacccgatg cctgcttgcc cgccaaagct    780

cctttcccaa gggaatgtat tctgccttgg caggtttttg tgatataggt gaaagtgtgg    840

aagagaccat ccgccgagaa gttgcagaag aggtgggatt ggaggtggaa agcctgcagt    900

actatgcatc ccagcattgg cccttcccta gtggctcact catgattgct tgccatgcaa    960

ctgtgaaacc agggcagaca gaaatccagg tgaacttgag agaattagag acagctgcct   1020

ggttcagtca tgatgaggta gccacagccc tgaagagaaa gggcccctat actcagcaac   1080

agaatgggac tttcccattc tggctgcccc ctaagttagc catctcccac caactgatta   1140

aggagtgggt ggaaaaacag acctgttctt ccctgcctgc ttagcccgga tcaagtcact   1200

tagatcgctc cttggtattc ctgagggaca aactagagat cagttgacaa aggagaagtg   1260

acaaaagata agctgcagaa ggacctcaga agggcagagc aaagggtgag cctacagtaa   1320

gacacttcta tcagcagtgt taatggaaga aattcctacc aatgggcaat caaaaaagcc   1380

agtgtgagaa gaaaactgat gagctgtcaa ctgtcaaaaa tcagggggaa gggggaagca   1440

ttagtttgga tgtaggccct tgttcagtca ttttctctaa ggccttggaa gcaaacatct   1500

tctggcatat ggcttgttaa tgttgtgttt acactaactg ccaaaatgtg cctgttgtaa   1560

gtttggttaa aacttttatc ttagtattga aaatatatag caagttttaa gtcattactg   1620

agttacttgt tacccttaca gaattaagaa aaatagcaca gtatgacatt ttaaaattca   1680

tgtacaggtg cattctagtt acatgaacat gctagttaaa taaaagtcac aattaagtca   1740

ttatgactca gagtacttta taataaatca gatgccctga ggctctgttg aggaagtaga   1800

atcccaatgg gactccagac agtaaatctt tttcgctgtt ttcagctctg tcacatgctc   1860

agtttgtgac ccagggaaaa gactattgct ttgccatgcc tgttttccta aataaaacag   1920

ttgctggcat ttgcacatcc acaacgtgtt gattaacaaa gggattggtg gagataaaca   1980

gatgccaaac ctgacctatt tcttaaactt tatggaataa actaaattta ggatttctca   2040

tcattcatat atgatgccat aagggagaag agtttatttg gggaaaataa aagaaatttc   2100

cacaaaaaaa aaaaaaaaaa                                               2120


<210>  2537
<211>  352
<212>  PRT
<213>  Homosapiens

<400>  2537

Met Ser Leu Tyr Cys Gly Ile Ala Cys Arg Arg Lys Phe Phe Trp Cys 
1               5                   10                  15      


Tyr Arg Leu Leu Ser Thr Tyr Val Thr Lys Thr Arg Tyr Leu Phe Glu 
            20                  25                  30          


Leu Lys Glu Asp Asp Asp Ala Cys Lys Lys Ala Gln Gln Thr Gly Ala 
        35                  40                  45              


Phe Tyr Leu Phe His Ser Leu Ala Pro Leu Leu Gln Thr Ser Ala His 
    50                  55                  60                  


Gln Tyr Leu Ala Pro Arg His Ser Leu Leu Glu Leu Glu Arg Leu Leu 
65                  70                  75                  80  


Gly Lys Phe Gly Gln Asp Ala Gln Arg Ile Glu Asp Ser Val Leu Ile 
                85                  90                  95      


Gly Cys Ser Glu Gln Gln Glu Ala Trp Phe Ala Leu Asp Leu Gly Leu 
            100                 105                 110         


Asp Ser Ser Phe Ser Ile Ser Ala Ser Leu His Lys Pro Glu Met Glu 
        115                 120                 125             


Thr Glu Leu Lys Gly Ser Phe Ile Glu Leu Arg Lys Ala Leu Phe Gln 
    130                 135                 140                 


Leu Asn Ala Arg Asp Ala Ser Leu Leu Ser Thr Ala Gln Ala Leu Leu 
145                 150                 155                 160 


Arg Trp His Asp Ala His Gln Phe Cys Ser Arg Ser Gly Gln Pro Thr 
                165                 170                 175     


Lys Lys Asn Val Ala Gly Ser Lys Arg Val Cys Pro Ser Asn Asn Ile 
            180                 185                 190         


Ile Tyr Tyr Pro Gln Met Ala Pro Val Ala Ile Thr Leu Val Ser Asp 
        195                 200                 205             


Gly Thr Arg Cys Leu Leu Ala Arg Gln Ser Ser Phe Pro Lys Gly Met 
    210                 215                 220                 


Tyr Ser Ala Leu Ala Gly Phe Cys Asp Ile Gly Glu Ser Val Glu Glu 
225                 230                 235                 240 


Thr Ile Arg Arg Glu Val Ala Glu Glu Val Gly Leu Glu Val Glu Ser 
                245                 250                 255     


Leu Gln Tyr Tyr Ala Ser Gln His Trp Pro Phe Pro Ser Gly Ser Leu 
            260                 265                 270         


Met Ile Ala Cys His Ala Thr Val Lys Pro Gly Gln Thr Glu Ile Gln 
        275                 280                 285             


Val Asn Leu Arg Glu Leu Glu Thr Ala Ala Trp Phe Ser His Asp Glu 
    290                 295                 300                 


Val Ala Thr Ala Leu Lys Arg Lys Gly Pro Tyr Thr Gln Gln Gln Asn 
305                 310                 315                 320 


Gly Thr Phe Pro Phe Trp Leu Pro Pro Lys Leu Ala Ile Ser His Gln 
                325                 330                 335     


Leu Ile Lys Glu Trp Val Glu Lys Gln Thr Cys Ser Ser Leu Pro Ala 
            340                 345                 350         


<210>  2538
<211>  2200
<212>  DNA
<213>  Homosapiens

<400>  2538
caaggtttcg gggactgagt gggtttcaga ctttctctca ggatttccgc tggcttcagg     60

ttccggtcag gcgtcgggac agagcctgat ccaggcttcg gcggccggtg gcagctctcg    120

atcagctctc gcagtcggag aggcggctaa ggaaaggtgc cacagcagag acgcgaagga    180

gaggccctag aaccttttca aagaagaatg gaagaaacca tgaagcttgc tacgatggaa    240

gacacagtgg agtactgcct gttcctgata ccagatgagt caagggactc agataaacat    300

aaagagattc ttcagaagta cattgagaga ataatcactc ggtttgcacc tatgctggtc    360

ccctacatct ggcagaatca gcctttcaat cttaaatata aacctgggaa aggaggtgtt    420

cctgctcata tgtttggcgt gacaaagttt ggggataaca ttgaggatga atggtttatt    480

gtttatgtaa taaagcagat cacaaaggaa tttccagagt tagtagcaag gattgaagac    540

aatgatggtg aattcttgtt aatagaagct gctgactttc tccctaaatg gctggatcct    600

gaaaatagca ccaatagggt atttttctgc catggggaat tgtgtattat ccctgcacca    660

agaaaatctg gagcagaatc ttggttaccc accacacccc caacaattcc acaagcattg    720

aatataatca cagcacattc agaaaaaata cttgcttcag aatctatacg agctgctgtg    780

aataggcgca tcagagggta cccagaaaaa attcaggcct cacttcatcg agcacactgc    840

ttccttccag ctggcattgt ggcagtgcta aagcagcgcc ccagattggt ggctgcagca    900

gtccaggcat tttacctacg agaccctatt gacctgcgag cttgtcgtgt tttcaagaca    960

ttcttgcctg aaacacgaat aatgacatcg gtcacattca ctaaatgtct atatgcacaa   1020

ttggtgcaac aaaggtttgt gccagaccgg cggagtggat acaggctgcc tcctccatct   1080

gatccccagt accgagccca tgaattgggc atgaaattgg ctcatggatt tgagatctta   1140

tgctccaaat gtagcccaca tttttctgac tgcaagaaat cccttgtgac tgcctcacca   1200

ctctgggcca gtttccttga aagtctgaaa aagaatgatt actttaaggg actgatagaa   1260

ggttctgctc agtaccggga aaggctagaa atggcagaga attacttcca gctctcagta   1320

gactggccag aaagttctct tgctatgagc cctggtgaag aaatcttaac cttattacag   1380

acaataccat ttgatataga agaccttaag aaagaagcag ctaatcttcc cccagaggat   1440

gatgaccagt ggttagatct ctcaccagat cagctggacc agctgctgca ggaagctgtt   1500

ggcaaaaaag aatccgagtc tgtttccaag gaggagaagg agcagaacta tgacttaact   1560

gaagtctcag agagcatgaa agctttcata tccaaagtct caacccacaa gggagcagag   1620

ctgcctcgag aaccttctga ggctccaatc acttttgatg cagattcttt tcttaattat   1680

tttgataaga ttttagggcc aaggcctaat gagtcagatt ctgatgatct ggatgatgaa   1740

gactttgaat gtttagatag tgatgatgac ttggactttg aaacacacga acctggcgaa   1800

gaggcttccc tgaaaggaac acttgataat ctcaagtcat acatggccca gatggaccag   1860

gaactagcac acacctgcat cagcaaaagt ttcaccacta ggaaccaagt ggaacctgta   1920

tcccagacta ccgataacaa ttcagatgag gaagattctg gtacgggaga atctgttatg   1980

gcaccagtag atgtagacct gaacctggtt tcaaatatat tggaatccta tagctcccaa   2040

gctggactgg caggacctgc ttccaatctt ttacaaagca tgggagtgca gctgcctgac   2100

aacaccgatc acagaccaac aagtaagcca acaaaaaatt aaccagcaca tttagcttct   2160

cttttttctt tttaaataaa tattgaatat gattctgttc                         2200


<210>  2539
<211>  644
<212>  PRT
<213>  Homosapiens

<400>  2539

Met Glu Glu Thr Met Lys Leu Ala Thr Met Glu Asp Thr Val Glu Tyr 
1               5                   10                  15      


Cys Leu Phe Leu Ile Pro Asp Glu Ser Arg Asp Ser Asp Lys His Lys 
            20                  25                  30          


Glu Ile Leu Gln Lys Tyr Ile Glu Arg Ile Ile Thr Arg Phe Ala Pro 
        35                  40                  45              


Met Leu Val Pro Tyr Ile Trp Gln Asn Gln Pro Phe Asn Leu Lys Tyr 
    50                  55                  60                  


Lys Pro Gly Lys Gly Gly Val Pro Ala His Met Phe Gly Val Thr Lys 
65                  70                  75                  80  


Phe Gly Asp Asn Ile Glu Asp Glu Trp Phe Ile Val Tyr Val Ile Lys 
                85                  90                  95      


Gln Ile Thr Lys Glu Phe Pro Glu Leu Val Ala Arg Ile Glu Asp Asn 
            100                 105                 110         


Asp Gly Glu Phe Leu Leu Ile Glu Ala Ala Asp Phe Leu Pro Lys Trp 
        115                 120                 125             


Leu Asp Pro Glu Asn Ser Thr Asn Arg Val Phe Phe Cys His Gly Glu 
    130                 135                 140                 


Leu Cys Ile Ile Pro Ala Pro Arg Lys Ser Gly Ala Glu Ser Trp Leu 
145                 150                 155                 160 


Pro Thr Thr Pro Pro Thr Ile Pro Gln Ala Leu Asn Ile Ile Thr Ala 
                165                 170                 175     


His Ser Glu Lys Ile Leu Ala Ser Glu Ser Ile Arg Ala Ala Val Asn 
            180                 185                 190         


Arg Arg Ile Arg Gly Tyr Pro Glu Lys Ile Gln Ala Ser Leu His Arg 
        195                 200                 205             


Ala His Cys Phe Leu Pro Ala Gly Ile Val Ala Val Leu Lys Gln Arg 
    210                 215                 220                 


Pro Arg Leu Val Ala Ala Ala Val Gln Ala Phe Tyr Leu Arg Asp Pro 
225                 230                 235                 240 


Ile Asp Leu Arg Ala Cys Arg Val Phe Lys Thr Phe Leu Pro Glu Thr 
                245                 250                 255     


Arg Ile Met Thr Ser Val Thr Phe Thr Lys Cys Leu Tyr Ala Gln Leu 
            260                 265                 270         


Val Gln Gln Arg Phe Val Pro Asp Arg Arg Ser Gly Tyr Arg Leu Pro 
        275                 280                 285             


Pro Pro Ser Asp Pro Gln Tyr Arg Ala His Glu Leu Gly Met Lys Leu 
    290                 295                 300                 


Ala His Gly Phe Glu Ile Leu Cys Ser Lys Cys Ser Pro His Phe Ser 
305                 310                 315                 320 


Asp Cys Lys Lys Ser Leu Val Thr Ala Ser Pro Leu Trp Ala Ser Phe 
                325                 330                 335     


Leu Glu Ser Leu Lys Lys Asn Asp Tyr Phe Lys Gly Leu Ile Glu Gly 
            340                 345                 350         


Ser Ala Gln Tyr Arg Glu Arg Leu Glu Met Ala Glu Asn Tyr Phe Gln 
        355                 360                 365             


Leu Ser Val Asp Trp Pro Glu Ser Ser Leu Ala Met Ser Pro Gly Glu 
    370                 375                 380                 


Glu Ile Leu Thr Leu Leu Gln Thr Ile Pro Phe Asp Ile Glu Asp Leu 
385                 390                 395                 400 


Lys Lys Glu Ala Ala Asn Leu Pro Pro Glu Asp Asp Asp Gln Trp Leu 
                405                 410                 415     


Asp Leu Ser Pro Asp Gln Leu Asp Gln Leu Leu Gln Glu Ala Val Gly 
            420                 425                 430         


Lys Lys Glu Ser Glu Ser Val Ser Lys Glu Glu Lys Glu Gln Asn Tyr 
        435                 440                 445             


Asp Leu Thr Glu Val Ser Glu Ser Met Lys Ala Phe Ile Ser Lys Val 
    450                 455                 460                 


Ser Thr His Lys Gly Ala Glu Leu Pro Arg Glu Pro Ser Glu Ala Pro 
465                 470                 475                 480 


Ile Thr Phe Asp Ala Asp Ser Phe Leu Asn Tyr Phe Asp Lys Ile Leu 
                485                 490                 495     


Gly Pro Arg Pro Asn Glu Ser Asp Ser Asp Asp Leu Asp Asp Glu Asp 
            500                 505                 510         


Phe Glu Cys Leu Asp Ser Asp Asp Asp Leu Asp Phe Glu Thr His Glu 
        515                 520                 525             


Pro Gly Glu Glu Ala Ser Leu Lys Gly Thr Leu Asp Asn Leu Lys Ser 
    530                 535                 540                 


Tyr Met Ala Gln Met Asp Gln Glu Leu Ala His Thr Cys Ile Ser Lys 
545                 550                 555                 560 


Ser Phe Thr Thr Arg Asn Gln Val Glu Pro Val Ser Gln Thr Thr Asp 
                565                 570                 575     


Asn Asn Ser Asp Glu Glu Asp Ser Gly Thr Gly Glu Ser Val Met Ala 
            580                 585                 590         


Pro Val Asp Val Asp Leu Asn Leu Val Ser Asn Ile Leu Glu Ser Tyr 
        595                 600                 605             


Ser Ser Gln Ala Gly Leu Ala Gly Pro Ala Ser Asn Leu Leu Gln Ser 
    610                 615                 620                 


Met Gly Val Gln Leu Pro Asp Asn Thr Asp His Arg Pro Thr Ser Lys 
625                 630                 635                 640 


Pro Thr Lys Asn 
                


<210>  2540
<211>  1450
<212>  DNA
<213>  Homosapiens

<400>  2540
cgaaaaagaa gcagtcctgg gctgtacccg gcgcagctgg gagcggctgc ttcctccggg     60

gtcgtatctc cgcccggcat ggggctgctg gacctttgcg aggaagtgtt cggcaccgcc    120

gacctttacc gggtgctggg cgtgcgacgc gaggcctccg acggcgaggt ccgacgaggc    180

taccacaagg tgtccctgca ggtacacccg gaccgggtgg gcgagggcga caaggaggac    240

gccacccgcc gcttccagat cctgggaaaa gtctattccg ttctcagtga cagagaacag    300

agagcagtgt acgatgagca gggaacagtg gacgaggact ctcctgtgct cacccaagac    360

cgagactggg aggcgtattg gcggctactc tttaaaaaga tatctttaga ggacattcaa    420

gcttttgaaa agacatacaa aggttcggaa gaagagctgg ctgatattaa gcaggcctat    480

ctggacttca agggtgacat ggatcagatc atggagtctg tgctttgcgt gcagtacaca    540

gaggaaccca ggataaggaa tatcattcag caagctattg acgccggaga ggtcccatcc    600

tataatgcct ttgtcaaaga atcgaaacaa aagatgaatg caaggaaaag gagggctcag    660

gaagaggcca aagaagcaga aatgagcaga aaggagttgg ggcttgatga aggcgtggat    720

agcctgaagg cagccattca gagcagacaa aaggatcggc aaaaggaaat ggacaatttt    780

ctggctcaga tggaagcaaa gtactgcaaa tcttccaaag gaggagggaa aaaatctgct    840

ctcaagaaag aaaagaaata atggaatttt tctcttcaaa ggtccttagg tgtaaattga    900

tgccatcgta ggcaaggtgc aggcaagatt tgaaggcaaa agtcaattca gctcttgaga    960

aaaggtgtct ttccagcctg aatttttcag attgactaga ccaagcagaa tctctcaacc   1020

tgatcttagt atttcctaga aagcacttga cattgtgtga ggtctcacct gaaggaactt   1080

ggtggtgaca tttgggaggg tggagggagg cagtgtcctt cctgacagca cttgcctcca   1140

tggatcttct gtacacagaa ctcttatcta ggatgtggtt ctgttcatgc tgctttctgc   1200

gatgtgcgtg tctgttagaa taggctctct acccagctag aacaccttcc agacacttgc   1260

tggacagcta tcttccacat acttcccagt ttacatttgg tcttaatgat cttgaataga   1320

tcctctcttc attttactca gccaggtttt gtactgatgt acaggtgtta aattacttca   1380

agcatttttg taagaggtgt atataattca ataaaaaagg taagacatga tgattaaaaa   1440

aaaaaaaaaa                                                          1450


<210>  2541
<211>  260
<212>  PRT
<213>  Homosapiens

<400>  2541

Met Gly Leu Leu Asp Leu Cys Glu Glu Val Phe Gly Thr Ala Asp Leu 
1               5                   10                  15      


Tyr Arg Val Leu Gly Val Arg Arg Glu Ala Ser Asp Gly Glu Val Arg 
            20                  25                  30          


Arg Gly Tyr His Lys Val Ser Leu Gln Val His Pro Asp Arg Val Gly 
        35                  40                  45              


Glu Gly Asp Lys Glu Asp Ala Thr Arg Arg Phe Gln Ile Leu Gly Lys 
    50                  55                  60                  


Val Tyr Ser Val Leu Ser Asp Arg Glu Gln Arg Ala Val Tyr Asp Glu 
65                  70                  75                  80  


Gln Gly Thr Val Asp Glu Asp Ser Pro Val Leu Thr Gln Asp Arg Asp 
                85                  90                  95      


Trp Glu Ala Tyr Trp Arg Leu Leu Phe Lys Lys Ile Ser Leu Glu Asp 
            100                 105                 110         


Ile Gln Ala Phe Glu Lys Thr Tyr Lys Gly Ser Glu Glu Glu Leu Ala 
        115                 120                 125             


Asp Ile Lys Gln Ala Tyr Leu Asp Phe Lys Gly Asp Met Asp Gln Ile 
    130                 135                 140                 


Met Glu Ser Val Leu Cys Val Gln Tyr Thr Glu Glu Pro Arg Ile Arg 
145                 150                 155                 160 


Asn Ile Ile Gln Gln Ala Ile Asp Ala Gly Glu Val Pro Ser Tyr Asn 
                165                 170                 175     


Ala Phe Val Lys Glu Ser Lys Gln Lys Met Asn Ala Arg Lys Arg Arg 
            180                 185                 190         


Ala Gln Glu Glu Ala Lys Glu Ala Glu Met Ser Arg Lys Glu Leu Gly 
        195                 200                 205             


Leu Asp Glu Gly Val Asp Ser Leu Lys Ala Ala Ile Gln Ser Arg Gln 
    210                 215                 220                 


Lys Asp Arg Gln Lys Glu Met Asp Asn Phe Leu Ala Gln Met Glu Ala 
225                 230                 235                 240 


Lys Tyr Cys Lys Ser Ser Lys Gly Gly Gly Lys Lys Ser Ala Leu Lys 
                245                 250                 255     


Lys Glu Lys Lys 
            260 


<210>  2542
<211>  2651
<212>  DNA
<213>  Homosapiens

<400>  2542
attgtgggaa gtatagggcg gcaagcggag gaggcgtggc gagcggatca tccgcttccg     60

gagtcgaggt tttcgggctt gtaccgcttg gcggtgcggc ctggtgtcgg cttgcaggtt    120

ctttctgtgt ttgttctctg ccctgccaag gccgtagagc tggtgcgtgc gggtagcggg    180

gctctccgag gagccgcacg ccggcggcac catggtccac ctcactactc tcctctgcaa    240

ggcctaccgt gggggccact taaccatccg ccttgccctg ggtggctgca ccaatcggcc    300

gttctaccgc attgtggctg ctcacaacaa gtgtcccagg gatggccgtt tcgtagagca    360

gctgggctcc tatgatccat tgcccaacag tcatggagaa aaactcgttg ccctcaacct    420

agacaggatc cgtcattgga ttggctgcgg ggcccacctc tctaagccta tggaaaagct    480

tctgggtctt gctggctttt tccctctgca tcctatgatg atcacaaatg ctgagagact    540

gcgaaggaaa cgggcacgtg aagtcctgtt agcttctcag aaaacagatg cagaagctac    600

agatacagag gctacagaaa cataaatgag ctgactttag tgagcatagc agtgggaaca    660

aggtcaaggt ccttttgaaa cactgcagcg atcttaattt tgttagattt ggagttcaat    720

aaatggagta tcctgagttg cccttgctct tctggcctgg cctgcacagg gcccagggag    780

agatttgttc ttgtgtgact tagagctggg tgtgggtact aattagcttt tttcgacttt    840

gtcttgggat agacagtggc tatgggagga ttggactttt gagttgggct ctgggtctct    900

tggacaactt tacaatttac tggcttccaa gacttcctgc ttcaaaaccc ccagccagac    960

tattcatggc ccattcagat cttcatgttc atcccacaag tgcaagaaca gttaaccttt   1020

cttaattgat ttttgtaatt ggaggtttat attgtcttgc ctaatgcata ttctcttttt   1080

tttttttttt ttgagacgga gtcttgttct gttgccaggc tggagtgcgg tggtgcaatc   1140

tcagctcact gcaatctcca cctcctgggt tcaagaggtt ctcctgcctc agcctcctga   1200

gtagccgggg agctacaagc atgcaccacc acacccagct aatttttttt ttttttttga   1260

gaggagtctc gctctgtcgc ccaggcttga gtgcagtggc gcgatctcgg ctcactgcaa   1320

gctctgtctc ctgggttcat gccattctcc tgcttcagcc tcccgagtag tcccaggagt   1380

agctgggact acaggtgccc accaccacac ccagctaatt tttttgtatt tttagtagag   1440

atggggtttc accatgttat ccaggatggt tttgatctcc tgacctcgtg atccgcccgc   1500

cttggcctcc caaaagtgct gggattatag gcgtgagcca ccgcccgggc aaatttttgt   1560

atttttagta gagatggggt ttcaccgtgt tggccaggat ggtctcaatc tgaccttgtg   1620

atctgcccac ctcggcctcc caaagtgcta ggattactgg cgtgagccac cactcctagc   1680

cttaatgcat attcttaaat atacaaaggt agatttgtta tgaaaattgc tttggggctc   1740

taataaccta ccttttaaga atgagaaact gctgggctta agggagttca gtatgaatca   1800

agattgaacc attcaaatgt ggctgtgatt tctgcatata tcatagatgg gatccttctg   1860

agaatactgg aatagggaat taggacacca agccaattca gctgtgaacc ttattcttgt   1920

acttttcttt cttgctggta attttatgga gcaggttaag aaggctgctc tgtgttagga   1980

taaactgtat accaataatg ttgacaacct gtaatgagtg ttgcatttta cttcttgtat   2040

cttttccttc ctaccttgat gccagtaatc tataagggat ctttatagtt tgaatgtatt   2100

tgaataactt cagtatactt tagttctact tttttatttg actcacaacc attcttaggt   2160

ctcaagtatt cccatgtgtt ttaaaagcct gaagtcagtg agatgaaatt caacatcaag   2220

aatttgaagt aacttgtaag gaaaaataat ataaagatac cattggggca gtggctcaca   2280

cctgtaatct cagcactttg ggaggctgag gtggaaggat cacttgaagc cagagtttga   2340

gaccagcctg tgcaacacag caagaccccg tctctacaaa aacttaaaaa attagctggc   2400

tgtggtgttg ctcacccata gttccagcta ctcgggaagc tgaggcagta agatcacttg   2460

agcccaggag gccgatgctg cagtgaactg tgattgttcc actacagtcc agcctgggtg   2520

acagagaaaa gaaaaagaaa acattacata atttggctag agcataataa tttgattttc   2580

tggtttttga aaatttgagt tgcaataaaa ggatatttca gtgtgcgatt tcaaaaaaaa   2640

aaaaaaaaaa a                                                        2651


<210>  2543
<211>  137
<212>  PRT
<213>  Homosapiens

<400>  2543

Met Val His Leu Thr Thr Leu Leu Cys Lys Ala Tyr Arg Gly Gly His 
1               5                   10                  15      


Leu Thr Ile Arg Leu Ala Leu Gly Gly Cys Thr Asn Arg Pro Phe Tyr 
            20                  25                  30          


Arg Ile Val Ala Ala His Asn Lys Cys Pro Arg Asp Gly Arg Phe Val 
        35                  40                  45              


Glu Gln Leu Gly Ser Tyr Asp Pro Leu Pro Asn Ser His Gly Glu Lys 
    50                  55                  60                  


Leu Val Ala Leu Asn Leu Asp Arg Ile Arg His Trp Ile Gly Cys Gly 
65                  70                  75                  80  


Ala His Leu Ser Lys Pro Met Glu Lys Leu Leu Gly Leu Ala Gly Phe 
                85                  90                  95      


Phe Pro Leu His Pro Met Met Ile Thr Asn Ala Glu Arg Leu Arg Arg 
            100                 105                 110         


Lys Arg Ala Arg Glu Val Leu Leu Ala Ser Gln Lys Thr Asp Ala Glu 
        115                 120                 125             


Ala Thr Asp Thr Glu Ala Thr Glu Thr 
    130                 135         


<210>  2544
<211>  3707
<212>  DNA
<213>  Homosapiens

<400>  2544
agcgtctcgc tccctgctcc cggccccaga gggttatcgc gagtcttgga ataaacttgc     60

tcgtgcgatg gccaaaaaga ccaaagaaaa cagagggact tttcccagtt ggtgatatgg    120

agcaagtgcc atcagcaggc agactcgtgc agatcaccgt gacagaggga tatgatttga    180

aaggttttaa aggagatact ccagttacct ttattcgagc agaattcaat caagtggttc    240

tgggagactc tgcaaaaatt actgtttctc cagaaggaag tgcaaaatac aacttcacta    300

gcagttttga gtttaatcct gaaggaggaa tcacttcaga tgacctcgct cacaaacctg    360

tgttcttaac tgtgactgaa gttttaccaa aggaaaagaa acagaaagaa gagaagacct    420

taattcttgg tcaggctgtg gtggaccttc ttcccttact ggaaggacag agttcatttc    480

aaacaacagt tccattgcac cctgtgcaag gctcaccctt agaaactcct agatcaagtg    540

ctaagcagtg cagtcttgaa gttaaagtat tagtggcaga gcctttactg accacagccc    600

agatctcagg gggcaatcta ctgaaggtca cgttggaggc tgcttactct gtgcctgaat    660

ccttcattcc aacaggtcct gggcagaact acatggtcgg tctgcaagtt ccatcacttg    720

gagagaagga ctatcccatt ttatttaaga atggaactct gaagcttgga ggggaaaggg    780

aacctgttcc ccggcccaaa aagtggccaa ttgccaacat tctggctcca ggagctaata    840

acattcctga tgcattcatt gttggtggtc cctatgaaga agaagaagga gaactcaacc    900

atcctgagga cagcgaattt aggaatcaag cagagtgcat aaagaaaagg attatttggg    960

acttggaaag tcgctgctac cttgatcctt ctgcagtggt cagttttcag aagcgaattg   1020

ccgattgccg gctttggcct gtagagatca caagagttcc tctggtcact atacccaaag   1080

ggaaagctgg caaaactgaa aagactgatg aagaagctca gctttcgttt catggtgtgg   1140

cttatgttaa tatggtccca ttgttgtatc caggtgtgaa gagaattcgg ggagcttttc   1200

atgtttaccc ttacctagac agtgtagtcc atgaaaagac caaatgttta ttgagcttgt   1260

tccgggatat tggccatcac ttgattcata ataataaaat aggaggaatt aattctctgc   1320

tgtccaaaca agctgtttct aagaatctga aagaagataa accagtgaaa gaaaaggata   1380

tagatggaag gcctaggcct ggggatgtgc aggcacctag tataaaatct cagagctcag   1440

atactccttt ggaaggtgaa ccccctctaa gtcacaatcc tgaaggacag caatatgtag   1500

aagcagggac atacattgtg ttggaaattc agttggacaa agccttggtt ccaaagcgaa   1560

tgccagagga gctagccaga agggtcaagg aaatgattcc tccaaggcct cctcttaccc   1620

gtcggacagg aggagctcag aaggcagtga gtgactacca catacagatc aagaatattt   1680

ctagagccat tctagatgaa tactacagaa tgtttggaaa acaggtggcc aaactggaga   1740

gtgatatgga tagtgaaacc ttggaggagc agaagtgcca gctcagctat gaacttaatt   1800

gctctggaaa atactttgct ttcaaagaac aactcaagca tgctgtggta aagattgtga   1860

gagataaata cttgaagaca acatcatttg aaagccagga ggaacttcag acatttatca   1920

gtgagctcta tgtgttctta gtagatcaga tgcatgtagc cctaaaccag accatgccag   1980

atgatgtcca aggcactgtt gcaaccattt atacaagcag tgaacagctt caactctttg   2040

catttgaagc agaagtcaat gagaactttg agatggcagc agcatattat aaagagagat   2100

tggtccgtga gccccagaat ctggatcact ggttggacta tggtgccttc tgcctcctaa   2160

ctgaagacaa catcaaagca caagagtgtt ttcagaaagc cctttccctc aaccagagtc   2220

atatccacag cttgttgctg tgtggtgtcc tggctgtcct gttggagaac tatgagcaag   2280

cagaaatttt ctttgaggat gctacttgct tggaaccaac taatgttgta gcctggactt   2340

tacttggttt gtactatgaa attcaaaaca atgatattcg aatggaaatg gcatttcatg   2400

aggcctccaa acagcttcag gcacggatgc ttcaggcaca agtaacaaag caaaagagca   2460

ctggtgtaga agacactgag gaaagaggga agagagaatc tagtttaggc ccttggggaa   2520

tcacaaatgg ttctgcaaca gcaatcaagg tggaagcccc agcaggacca ggagctgcat   2580

tatctattct agacaaattt cttgaagaat cctccaaact gcagtctgat tcacaagaac   2640

ccattttgac tacacaaact tgggatccaa gtataagcca aaaaccatct aacacattta   2700

tcaaggagat accaacaaag aaagaagcat caaaatgtca agattcatca gctcttctgc   2760

atcccggcct tcattatggt gtttctcaaa ctaccaccat cttcatggag accatacatt   2820

tcttgatgaa agtcaaggct gtgcagtatg tgcacagagt gcttgcacat gagctgttat   2880

gccctcaagg aggccccagc tgtgaatatt acttggtgct ggcccaaaca cacattctta   2940

agaagaactt tgccaaggca gaggaatacc ttcaacaagc agcccagatg gactacctga   3000

accccaatgt ctggggcctg aagggccatc tctattttct gagtggaaat cattctgagg   3060

ccaaggcatg ctatgaacga accattagct ttgtagtgga tgcttctgag atgcacttca   3120

tcttcctgag actggggctc atctatctgg aagagaaaga gtatgaaaag gcaaagaaaa   3180

cctatatgca agcctgtaag agatcacctt catgccttac ctggctagga ctgggaatcg   3240

cctgctatcg gctggaggag ctcacagagg ctgaggatgc tctttctgaa gccaatgcat   3300

tgaacaacta caatgctgaa gtatgggcat atctggctct ggtctgcctg aaagttggac   3360

ggcaattaga agctgagcag gcctacaagt acatgatcaa gctgaaattg aaagatgagg   3420

ctctgcttgc agagatccac acactacagg aaacagttgg ctttggaaat ccatctttct   3480

gatacccctc cagctgaaca attttctgca tgggactctg agttcctttc cttcccagag   3540

agttttaccg tatgaagcct ggagctggag aacgaaagaa tcttcactat aaacagagac   3600

ccattcattt atttccattg gctgtgttac tggatgtttt actggttgac gagaaactgg   3660

gtcacaataa aaaaatggag atatgaaact caaaaaaaaa aaaaaaa                 3707


<210>  2545
<211>  1121
<212>  PRT
<213>  Homosapiens

<400>  2545

Met Glu Gln Val Pro Ser Ala Gly Arg Leu Val Gln Ile Thr Val Thr 
1               5                   10                  15      


Glu Gly Tyr Asp Leu Lys Gly Phe Lys Gly Asp Thr Pro Val Thr Phe 
            20                  25                  30          


Ile Arg Ala Glu Phe Asn Gln Val Val Leu Gly Asp Ser Ala Lys Ile 
        35                  40                  45              


Thr Val Ser Pro Glu Gly Ser Ala Lys Tyr Asn Phe Thr Ser Ser Phe 
    50                  55                  60                  


Glu Phe Asn Pro Glu Gly Gly Ile Thr Ser Asp Asp Leu Ala His Lys 
65                  70                  75                  80  


Pro Val Phe Leu Thr Val Thr Glu Val Leu Pro Lys Glu Lys Lys Gln 
                85                  90                  95      


Lys Glu Glu Lys Thr Leu Ile Leu Gly Gln Ala Val Val Asp Leu Leu 
            100                 105                 110         


Pro Leu Leu Glu Gly Gln Ser Ser Phe Gln Thr Thr Val Pro Leu His 
        115                 120                 125             


Pro Val Gln Gly Ser Pro Leu Glu Thr Pro Arg Ser Ser Ala Lys Gln 
    130                 135                 140                 


Cys Ser Leu Glu Val Lys Val Leu Val Ala Glu Pro Leu Leu Thr Thr 
145                 150                 155                 160 


Ala Gln Ile Ser Gly Gly Asn Leu Leu Lys Val Thr Leu Glu Ala Ala 
                165                 170                 175     


Tyr Ser Val Pro Glu Ser Phe Ile Pro Thr Gly Pro Gly Gln Asn Tyr 
            180                 185                 190         


Met Val Gly Leu Gln Val Pro Ser Leu Gly Glu Lys Asp Tyr Pro Ile 
        195                 200                 205             


Leu Phe Lys Asn Gly Thr Leu Lys Leu Gly Gly Glu Arg Glu Pro Val 
    210                 215                 220                 


Pro Arg Pro Lys Lys Trp Pro Ile Ala Asn Ile Leu Ala Pro Gly Ala 
225                 230                 235                 240 


Asn Asn Ile Pro Asp Ala Phe Ile Val Gly Gly Pro Tyr Glu Glu Glu 
                245                 250                 255     


Glu Gly Glu Leu Asn His Pro Glu Asp Ser Glu Phe Arg Asn Gln Ala 
            260                 265                 270         


Glu Cys Ile Lys Lys Arg Ile Ile Trp Asp Leu Glu Ser Arg Cys Tyr 
        275                 280                 285             


Leu Asp Pro Ser Ala Val Val Ser Phe Gln Lys Arg Ile Ala Asp Cys 
    290                 295                 300                 


Arg Leu Trp Pro Val Glu Ile Thr Arg Val Pro Leu Val Thr Ile Pro 
305                 310                 315                 320 


Lys Gly Lys Ala Gly Lys Thr Glu Lys Thr Asp Glu Glu Ala Gln Leu 
                325                 330                 335     


Ser Phe His Gly Val Ala Tyr Val Asn Met Val Pro Leu Leu Tyr Pro 
            340                 345                 350         


Gly Val Lys Arg Ile Arg Gly Ala Phe His Val Tyr Pro Tyr Leu Asp 
        355                 360                 365             


Ser Val Val His Glu Lys Thr Lys Cys Leu Leu Ser Leu Phe Arg Asp 
    370                 375                 380                 


Ile Gly His His Leu Ile His Asn Asn Lys Ile Gly Gly Ile Asn Ser 
385                 390                 395                 400 


Leu Leu Ser Lys Gln Ala Val Ser Lys Asn Leu Lys Glu Asp Lys Pro 
                405                 410                 415     


Val Lys Glu Lys Asp Ile Asp Gly Arg Pro Arg Pro Gly Asp Val Gln 
            420                 425                 430         


Ala Pro Ser Ile Lys Ser Gln Ser Ser Asp Thr Pro Leu Glu Gly Glu 
        435                 440                 445             


Pro Pro Leu Ser His Asn Pro Glu Gly Gln Gln Tyr Val Glu Ala Gly 
    450                 455                 460                 


Thr Tyr Ile Val Leu Glu Ile Gln Leu Asp Lys Ala Leu Val Pro Lys 
465                 470                 475                 480 


Arg Met Pro Glu Glu Leu Ala Arg Arg Val Lys Glu Met Ile Pro Pro 
                485                 490                 495     


Arg Pro Pro Leu Thr Arg Arg Thr Gly Gly Ala Gln Lys Ala Val Ser 
            500                 505                 510         


Asp Tyr His Ile Gln Ile Lys Asn Ile Ser Arg Ala Ile Leu Asp Glu 
        515                 520                 525             


Tyr Tyr Arg Met Phe Gly Lys Gln Val Ala Lys Leu Glu Ser Asp Met 
    530                 535                 540                 


Asp Ser Glu Thr Leu Glu Glu Gln Lys Cys Gln Leu Ser Tyr Glu Leu 
545                 550                 555                 560 


Asn Cys Ser Gly Lys Tyr Phe Ala Phe Lys Glu Gln Leu Lys His Ala 
                565                 570                 575     


Val Val Lys Ile Val Arg Asp Lys Tyr Leu Lys Thr Thr Ser Phe Glu 
            580                 585                 590         


Ser Gln Glu Glu Leu Gln Thr Phe Ile Ser Glu Leu Tyr Val Phe Leu 
        595                 600                 605             


Val Asp Gln Met His Val Ala Leu Asn Gln Thr Met Pro Asp Asp Val 
    610                 615                 620                 


Gln Gly Thr Val Ala Thr Ile Tyr Thr Ser Ser Glu Gln Leu Gln Leu 
625                 630                 635                 640 


Phe Ala Phe Glu Ala Glu Val Asn Glu Asn Phe Glu Met Ala Ala Ala 
                645                 650                 655     


Tyr Tyr Lys Glu Arg Leu Val Arg Glu Pro Gln Asn Leu Asp His Trp 
            660                 665                 670         


Leu Asp Tyr Gly Ala Phe Cys Leu Leu Thr Glu Asp Asn Ile Lys Ala 
        675                 680                 685             


Gln Glu Cys Phe Gln Lys Ala Leu Ser Leu Asn Gln Ser His Ile His 
    690                 695                 700                 


Ser Leu Leu Leu Cys Gly Val Leu Ala Val Leu Leu Glu Asn Tyr Glu 
705                 710                 715                 720 


Gln Ala Glu Ile Phe Phe Glu Asp Ala Thr Cys Leu Glu Pro Thr Asn 
                725                 730                 735     


Val Val Ala Trp Thr Leu Leu Gly Leu Tyr Tyr Glu Ile Gln Asn Asn 
            740                 745                 750         


Asp Ile Arg Met Glu Met Ala Phe His Glu Ala Ser Lys Gln Leu Gln 
        755                 760                 765             


Ala Arg Met Leu Gln Ala Gln Val Thr Lys Gln Lys Ser Thr Gly Val 
    770                 775                 780                 


Glu Asp Thr Glu Glu Arg Gly Lys Arg Glu Ser Ser Leu Gly Pro Trp 
785                 790                 795                 800 


Gly Ile Thr Asn Gly Ser Ala Thr Ala Ile Lys Val Glu Ala Pro Ala 
                805                 810                 815     


Gly Pro Gly Ala Ala Leu Ser Ile Leu Asp Lys Phe Leu Glu Glu Ser 
            820                 825                 830         


Ser Lys Leu Gln Ser Asp Ser Gln Glu Pro Ile Leu Thr Thr Gln Thr 
        835                 840                 845             


Trp Asp Pro Ser Ile Ser Gln Lys Pro Ser Asn Thr Phe Ile Lys Glu 
    850                 855                 860                 


Ile Pro Thr Lys Lys Glu Ala Ser Lys Cys Gln Asp Ser Ser Ala Leu 
865                 870                 875                 880 


Leu His Pro Gly Leu His Tyr Gly Val Ser Gln Thr Thr Thr Ile Phe 
                885                 890                 895     


Met Glu Thr Ile His Phe Leu Met Lys Val Lys Ala Val Gln Tyr Val 
            900                 905                 910         


His Arg Val Leu Ala His Glu Leu Leu Cys Pro Gln Gly Gly Pro Ser 
        915                 920                 925             


Cys Glu Tyr Tyr Leu Val Leu Ala Gln Thr His Ile Leu Lys Lys Asn 
    930                 935                 940                 


Phe Ala Lys Ala Glu Glu Tyr Leu Gln Gln Ala Ala Gln Met Asp Tyr 
945                 950                 955                 960 


Leu Asn Pro Asn Val Trp Gly Leu Lys Gly His Leu Tyr Phe Leu Ser 
                965                 970                 975     


Gly Asn His Ser Glu Ala Lys Ala Cys Tyr Glu Arg Thr Ile Ser Phe 
            980                 985                 990         


Val Val Asp Ala Ser Glu Met His  Phe Ile Phe Leu Arg  Leu Gly Leu 
        995                 1000                 1005             


Ile Tyr  Leu Glu Glu Lys Glu  Tyr Glu Lys Ala Lys  Lys Thr Tyr 
    1010                 1015                 1020             


Met Gln  Ala Cys Lys Arg Ser  Pro Ser Cys Leu Thr  Trp Leu Gly 
    1025                 1030                 1035             


Leu Gly  Ile Ala Cys Tyr Arg  Leu Glu Glu Leu Thr  Glu Ala Glu 
    1040                 1045                 1050             


Asp Ala  Leu Ser Glu Ala Asn  Ala Leu Asn Asn Tyr  Asn Ala Glu 
    1055                 1060                 1065             


Val Trp  Ala Tyr Leu Ala Leu  Val Cys Leu Lys Val  Gly Arg Gln 
    1070                 1075                 1080             


Leu Glu  Ala Glu Gln Ala Tyr  Lys Tyr Met Ile Lys  Leu Lys Leu 
    1085                 1090                 1095             


Lys Asp  Glu Ala Leu Leu Ala  Glu Ile His Thr Leu  Gln Glu Thr 
    1100                 1105                 1110             


Val Gly  Phe Gly Asn Pro Ser  Phe 
    1115                 1120     


<210>  2546
<211>  2110
<212>  DNA
<213>  Homosapiens

<400>  2546
gaacccggtc tcccgcaaga tggagccggg ttgggctgtg acgctgctgc tggggtcaga     60

atgtcatacc caggctatcc cccaacaggc tacccacctt tccctggata tcctcctgca    120

ggtcaggagt catcttttcc cccttctggt cagtatcctt atcctagtgg ctttcctcca    180

atgggaggag gtgcctaccc acaagtgcca agtagtggct acccaggagc tggaggctac    240

cctgcgcctg gaggttatcc agcccctgga ggctatcctg gtgccccaca gccaggggga    300

gctccatcct atcccggagt tcctccaggc caaggatttg gagtcccacc aggtggagca    360

ggcttttctg ggtatccaca gccaccttca cagtcttatg gaggtggtcc agcacaggtt    420

ccactacctg gtggctttcc tggaggacag atgccttctc agtatcctgg aggacaacct    480

acttacccta gtcagcctgc cacagtgact caggtcactc aaggaactat ccgaccagct    540

gccaacttcg atgctataag agatgcagaa attcttcgta aggcaatgaa gggttttggg    600

acagatgagc aggcaattgt ggatgtggtg gccaaccgtt ccaatgatca gaggcaaaaa    660

attaaagcag catttaagac ctcctatggc aaggatttaa tcaaagatct caaatcagag    720

ttaagtggaa atatggaaga actgatcctg gccctcttca tgcctcctac gtattacgat    780

gcctggagct tacggaaagc aatgcaggga gcaggaactc aggaacgtgt attgattgag    840

attttgtgca caagaacaaa tcaggaaatc cgagaaattg tcagatgtta tcagtcagaa    900

tttggacgag accttgaaaa ggacattagg tcagatacat caggacattt tgaacgttta    960

cttgtgtcca tgtgccaggg aaatcgtgat gagaaccaga gtataaacca ccaaatggct   1020

caggaagatg ctcagcgtct ctatcaagct ggtgagggga gactagggac cgatgaatct   1080

tgctttaaca tgatccttgc cacaagaagc tttcctcagc tgagagctac catggaggct   1140

tattctagga tggctaatcg agacttgtta agcagtgtga gccgtgagtt ttccggatat   1200

gtagaaagtg gtttgaagac catcttgcag tgtgccctga accgccctgc cttctttgct   1260

gagaggctct actatgctat gaaaggtgct ggcacagatg actccaccct ggtccggatt   1320

gtggtcactc gaagtgagat tgaccttgta caaataaaac agatgttcgc tcagatgtat   1380

cagaagactc tgggcacaat gattgcaggt gacacgagtg gagattaccg aagacttctt   1440

ctggctattg tgggccagta ggagggattt tttttttttt aatgaaaaaa aaatttctat   1500

tcatagctta tccttcagag caatgacctg catgcagcaa tatcaaacat cagctaaccg   1560

aaagagcttt ctgtcaagga ccgtatcagg gtaatgtgct tggtttgcac atgttgttat   1620

tgccttaatt ctaattttat tttgttctct acatacaatc aatgtaaagc catatcacaa   1680

tgatacagta atattgcaat gtttgtaaac cttcattctt actagtttca ttctaatcaa   1740

gatgtcaaat tgaataaaaa tcacagcaat ctctgattct gtgtaataat attgaataat   1800

tttttagaag gttactgaaa gctctgcctt ccggaatccc tctaagtctg cttgatagag   1860

tggatagtat gttaaaactg tgtactttaa aaaaaaattc aacctttaca tctagaataa   1920

tttgcatctc attttgccta aattggttct gtattcataa acactttcca catagaaaat   1980

agattagtat tacctgtggc accttttaag aaagggtcaa atgtttatat gcttaagata   2040

catagcctcc ctttttttcg cgttgtttcc tttttttaaa ttgagttatg acaaataaaa   2100

aattgcatat                                                          2110


<210>  2547
<211>  466
<212>  PRT
<213>  Homosapiens

<400>  2547

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln 
465     


<210>  2548
<211>  2176
<212>  DNA
<213>  Homosapiens

<400>  2548
gaacccggtc tcccgcaaga tggagccggg ttgggctgtg acgctgctgc tggggtcaga     60

atgtcatacc caggctatcc cccaacaggc tacccacctt tccctggata tcctcctgca    120

ggtcaggagt catcttttcc cccttctggt cagtatcctt atcctagtgg ctttcctcca    180

atgggaggag gtgcctaccc acaagtgcca agtagtggct acccaggagc tggaggctac    240

cctgcgcctg gaggttatcc agcccctgga ggctatcctg gtgccccaca gccaggggga    300

gctccatcct atcccggagt tcctccaggc caaggatttg gagtcccacc aggtggagca    360

ggcttttctg ggtatccaca gccaccttca cagtcttatg gaggtggtcc agcacaggtt    420

ccactacctg gtggctttcc tggaggacag atgccttctc agtatcctgg aggacaacct    480

acttacccta gtcagatcaa tacagattct ttttcttcct atcctgtttt ctctcctgtt    540

tctttggatt atagcagtga acctgccaca gtgactcagg tcactcaagg aactatccga    600

ccagctgcca acttcgatgc tataagagat gcagaaattc ttcgtaaggc aatgaagggt    660

tttgggacag atgagcaggc aattgtggat gtggtggcca accgttccaa tgatcagagg    720

caaaaaatta aagcagcatt taagacctcc tatggcaagg atttaatcaa agatctcaaa    780

tcagagttaa gtggaaatat ggaagaactg atcctggccc tcttcatgcc tcctacgtat    840

tacgatgcct ggagcttacg gaaagcaatg cagggagcag gaactcagga acgtgtattg    900

attgagattt tgtgcacaag aacaaatcag gaaatccgag aaattgtcag atgttatcag    960

tcagaatttg gacgagacct tgaaaaggac attaggtcag atacatcagg acattttgaa   1020

cgtttacttg tgtccatgtg ccagggaaat cgtgatgaga accagagtat aaaccaccaa   1080

atggctcagg aagatgctca gcgtctctat caagctggtg aggggagact agggaccgat   1140

gaatcttgct ttaacatgat ccttgccaca agaagctttc ctcagctgag agctaccatg   1200

gaggcttatt ctaggatggc taatcgagac ttgttaagca gtgtgagccg tgagttttcc   1260

ggatatgtag aaagtggttt gaagaccatc ttgcagtgtg ccctgaaccg ccctgccttc   1320

tttgctgaga ggctctacta tgctatgaaa ggtgctggca cagatgactc caccctggtc   1380

cggattgtgg tcactcgaag tgagattgac cttgtacaaa taaaacagat gttcgctcag   1440

atgtatcaga agactctggg cacaatgatt gcaggtgaca cgagtggaga ttaccgaaga   1500

cttcttctgg ctattgtggg ccagtaggag ggattttttt ttttttaatg aaaaaaaaat   1560

ttctattcat agcttatcct tcagagcaat gacctgcatg cagcaatatc aaacatcagc   1620

taaccgaaag agctttctgt caaggaccgt atcagggtaa tgtgcttggt ttgcacatgt   1680

tgttattgcc ttaattctaa ttttattttg ttctctacat acaatcaatg taaagccata   1740

tcacaatgat acagtaatat tgcaatgttt gtaaaccttc attcttacta gtttcattct   1800

aatcaagatg tcaaattgaa taaaaatcac agcaatctct gattctgtgt aataatattg   1860

aataattttt tagaaggtta ctgaaagctc tgccttccgg aatccctcta agtctgcttg   1920

atagagtgga tagtatgtta aaactgtgta ctttaaaaaa aaattcaacc tttacatcta   1980

gaataatttg catctcattt tgcctaaatt ggttctgtat tcataaacac tttccacata   2040

gaaaatagat tagtattacc tgtggcacct tttaagaaag ggtcaaatgt ttatatgctt   2100

aagatacata gcctcccttt ttttcgcgtt gtttcctttt tttaaattga gttatgacaa   2160

ataaaaaatt gcatat                                                   2176


<210>  2549
<211>  488
<212>  PRT
<213>  Homosapiens

<400>  2549

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Ile Asn Thr Asp Ser Phe Ser Ser Tyr Pro Val Phe Ser Pro Val 
145                 150                 155                 160 


Ser Leu Asp Tyr Ser Ser Glu Pro Ala Thr Val Thr Gln Val Thr Gln 
                165                 170                 175     


Gly Thr Ile Arg Pro Ala Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu 
            180                 185                 190         


Ile Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile 
        195                 200                 205             


Val Asp Val Val Ala Asn Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys 
    210                 215                 220                 


Ala Ala Phe Lys Thr Ser Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys 
225                 230                 235                 240 


Ser Glu Leu Ser Gly Asn Met Glu Glu Leu Ile Leu Ala Leu Phe Met 
                245                 250                 255     


Pro Pro Thr Tyr Tyr Asp Ala Trp Ser Leu Arg Lys Ala Met Gln Gly 
            260                 265                 270         


Ala Gly Thr Gln Glu Arg Val Leu Ile Glu Ile Leu Cys Thr Arg Thr 
        275                 280                 285             


Asn Gln Glu Ile Arg Glu Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly 
    290                 295                 300                 


Arg Asp Leu Glu Lys Asp Ile Arg Ser Asp Thr Ser Gly His Phe Glu 
305                 310                 315                 320 


Arg Leu Leu Val Ser Met Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser 
                325                 330                 335     


Ile Asn His Gln Met Ala Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala 
            340                 345                 350         


Gly Glu Gly Arg Leu Gly Thr Asp Glu Ser Cys Phe Asn Met Ile Leu 
        355                 360                 365             


Ala Thr Arg Ser Phe Pro Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser 
    370                 375                 380                 


Arg Met Ala Asn Arg Asp Leu Leu Ser Ser Val Ser Arg Glu Phe Ser 
385                 390                 395                 400 


Gly Tyr Val Glu Ser Gly Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn 
                405                 410                 415     


Arg Pro Ala Phe Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala 
            420                 425                 430         


Gly Thr Asp Asp Ser Thr Leu Val Arg Ile Val Val Thr Arg Ser Glu 
        435                 440                 445             


Ile Asp Leu Val Gln Ile Lys Gln Met Phe Ala Gln Met Tyr Gln Lys 
    450                 455                 460                 


Thr Leu Gly Thr Met Ile Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg 
465                 470                 475                 480 


Leu Leu Leu Ala Ile Val Gly Gln 
                485             


<210>  2550
<211>  2433
<212>  DNA
<213>  Homosapiens

<400>  2550
atttcacttg gaggaaagag agaaggaagg aagctgagga cttagcaggg tatcactgga     60

caggccatgg ctccacggtc ccggcgacga aggcacaaga aacctccctc atcagtggct    120

cccatcatca tggccccaac cacaattgtg acccctgtgc ctctgacccc ctcaaaacct    180

ggccctagca ttgacacact tggcttcttc tccttggatg ataatgttcc tggcctatcg    240

cagctgatcc ttcaaaagct gaacatgaaa agctatgaag aatataagtt ggtggtagat    300

gggggtaccc ccgtatcagg ctttggattt cgatgtcctc aagaaatgtt ccagaggatg    360

gaagacacat ttcgattctg tgctcactgt agagcactcc ctagtgggct ttcagactcc    420

aaggttctcc ggcactgtaa gaggtgcaga aatgtctatt actgtggtcc agagtgccag    480

aagtcagact ggcccgcaca caggagggtt tgtcaagagc ttcgtcttgt ggctgtggac    540

cgtctcatgg aatggcttct ggtcacaggt gattttgttc taccctcagg accttggcca    600

tggccacctg aagctgtaca ggactgggac tcctggtttt ctatgaaggg gttacaccta    660

gatgctacat tggatgctgt gctagttagt catgctgtga ccaccttatg ggccagtgta    720

ggacggccaa ggccagaccc ggatgtcctg cagggatctt tgaagcggct gctgacagat    780

gtcctgtcac ggcccttgac tctaggccta ggacttaggg ccttggggat agatgttagg    840

aggactgggg gaagcacagt gcatgtggtt ggtgcttccc atgtggagac atttcttact    900

cgcccagggg actatgatga gcttggttac atgtttcctg ggcaccttgg actccgtgtg    960

gtcatggtgg gtgtagatgt agctactggc ttttcacaga gcacctcaac ttcacccctg   1020

gaacctggca caattcagct tagtgcccac aggggcctct accatgactt ctgggaggag   1080

caagtagaga ccgggcagac acaccatcca gatttggtgg cggcattcca tccaggtttt   1140

cattcctccc cagacttgat ggaggcttgg ctgcccaccc tgctgctact tcgtgactat   1200

aagattccta cattgattac tgtttacagc catcaggagt tggtatcctc tttgcagatt   1260

ctggtggaac tggatacaca catcactgcc tttgggtcta atcctttcat gtccctcaaa   1320

cctgaacagg tctattccag tcccaacaag cagccagtat actgcagtgc atactatatc   1380

atgtttcttg gaagctcctg tcagctggat aataggcaat tagaagagaa agtggacggc   1440

gggatttaaa tagatcataa ctggacatct ggaaaacggg gagtttgtga tgaaattacc   1500

ctgctaatgc caggttcttg caaactttga aaaacattat attctaaacc tcatttactg   1560

tttgggtaaa aattctaagc tgaatgagag tttctgtata acataactgg tttctttctt   1620

tttttgagat ggagtcttgc tctgttgccc aggctggagt gcagcggcat gatctcgact   1680

cactgcagcc tccgcctcct gggttcaagt ggttctcctg cctcagcctc cctagtagct   1740

gggattacag gtgcacacca ccacacctgg ctaatttttg tatttttagc agacagggtt   1800

tcaccatgtt ggccaggctc gtatcaaacc cttgacccca ggtgatctgc ctgcctcagc   1860

ctcccaaagt tctgggatta caggcatgag ccaccatgcc cagccaatgt aactggtttc   1920

taagagttta gccacagtag cttctagaga taggaaatta gatttagtgg gtgggaagag   1980

gccctgatgc tggtctttcc agagcttata gttgctaaca cttttctttg taaagaagtt   2040

taccttttga ctggaaccag atggcactga gaaaaagaat gagaaccacc ttattcttct   2100

gaaaaagact ttcttctcat ccagtaattt gggctaaaaa atggaaagat gttgatgact   2160

tgaagtgatg caagaatgga caagtcaggg aagtcattgg gaacatggat gaggttgtaa   2220

gcattggtac agtgtcctgt ttcctgactt ttttgagaga aatgtctact tttcctgttt   2280

tctcttgggg acttttgacc ctagagtagc cctggtgtta tattttagat atcccaagct   2340

atatcagact ttacctgaat atactggagt tacttattat cccccattct ataccccaat   2400

aaactcagtt tggggcttct taaaaaaaaa aaa                                2433


<210>  2551
<211>  460
<212>  PRT
<213>  Homosapiens

<400>  2551

Met Ala Pro Arg Ser Arg Arg Arg Arg His Lys Lys Pro Pro Ser Ser 
1               5                   10                  15      


Val Ala Pro Ile Ile Met Ala Pro Thr Thr Ile Val Thr Pro Val Pro 
            20                  25                  30          


Leu Thr Pro Ser Lys Pro Gly Pro Ser Ile Asp Thr Leu Gly Phe Phe 
        35                  40                  45              


Ser Leu Asp Asp Asn Val Pro Gly Leu Ser Gln Leu Ile Leu Gln Lys 
    50                  55                  60                  


Leu Asn Met Lys Ser Tyr Glu Glu Tyr Lys Leu Val Val Asp Gly Gly 
65                  70                  75                  80  


Thr Pro Val Ser Gly Phe Gly Phe Arg Cys Pro Gln Glu Met Phe Gln 
                85                  90                  95      


Arg Met Glu Asp Thr Phe Arg Phe Cys Ala His Cys Arg Ala Leu Pro 
            100                 105                 110         


Ser Gly Leu Ser Asp Ser Lys Val Leu Arg His Cys Lys Arg Cys Arg 
        115                 120                 125             


Asn Val Tyr Tyr Cys Gly Pro Glu Cys Gln Lys Ser Asp Trp Pro Ala 
    130                 135                 140                 


His Arg Arg Val Cys Gln Glu Leu Arg Leu Val Ala Val Asp Arg Leu 
145                 150                 155                 160 


Met Glu Trp Leu Leu Val Thr Gly Asp Phe Val Leu Pro Ser Gly Pro 
                165                 170                 175     


Trp Pro Trp Pro Pro Glu Ala Val Gln Asp Trp Asp Ser Trp Phe Ser 
            180                 185                 190         


Met Lys Gly Leu His Leu Asp Ala Thr Leu Asp Ala Val Leu Val Ser 
        195                 200                 205             


His Ala Val Thr Thr Leu Trp Ala Ser Val Gly Arg Pro Arg Pro Asp 
    210                 215                 220                 


Pro Asp Val Leu Gln Gly Ser Leu Lys Arg Leu Leu Thr Asp Val Leu 
225                 230                 235                 240 


Ser Arg Pro Leu Thr Leu Gly Leu Gly Leu Arg Ala Leu Gly Ile Asp 
                245                 250                 255     


Val Arg Arg Thr Gly Gly Ser Thr Val His Val Val Gly Ala Ser His 
            260                 265                 270         


Val Glu Thr Phe Leu Thr Arg Pro Gly Asp Tyr Asp Glu Leu Gly Tyr 
        275                 280                 285             


Met Phe Pro Gly His Leu Gly Leu Arg Val Val Met Val Gly Val Asp 
    290                 295                 300                 


Val Ala Thr Gly Phe Ser Gln Ser Thr Ser Thr Ser Pro Leu Glu Pro 
305                 310                 315                 320 


Gly Thr Ile Gln Leu Ser Ala His Arg Gly Leu Tyr His Asp Phe Trp 
                325                 330                 335     


Glu Glu Gln Val Glu Thr Gly Gln Thr His His Pro Asp Leu Val Ala 
            340                 345                 350         


Ala Phe His Pro Gly Phe His Ser Ser Pro Asp Leu Met Glu Ala Trp 
        355                 360                 365             


Leu Pro Thr Leu Leu Leu Leu Arg Asp Tyr Lys Ile Pro Thr Leu Ile 
    370                 375                 380                 


Thr Val Tyr Ser His Gln Glu Leu Val Ser Ser Leu Gln Ile Leu Val 
385                 390                 395                 400 


Glu Leu Asp Thr His Ile Thr Ala Phe Gly Ser Asn Pro Phe Met Ser 
                405                 410                 415     


Leu Lys Pro Glu Gln Val Tyr Ser Ser Pro Asn Lys Gln Pro Val Tyr 
            420                 425                 430         


Cys Ser Ala Tyr Tyr Ile Met Phe Leu Gly Ser Ser Cys Gln Leu Asp 
        435                 440                 445             


Asn Arg Gln Leu Glu Glu Lys Val Asp Gly Gly Ile 
    450                 455                 460 


<210>  2552
<211>  3079
<212>  DNA
<213>  Homosapiens

<400>  2552
gggccctaca gagggtccgc catgttcccc ggcggcgccg ccgcttggct ctggtagccg     60

ccgcccccgc ccccaacccc gcccggccca gagcctagcc gagccccggg cccagcatgg    120

ccgccccgga gccggcccgg gctgcaccgc ccccaccccc gcccccgccg ccccctcccg    180

gggctgaccg cgtcgtcaaa gctgtccctt tccccccaac acatcgcttg acatctgaag    240

aagtatttga tttggatggg atacccaggg ttgatgttct gaagaaccac ttggtgaaag    300

aaggtcgagt agatgaagaa attgcgctta gaattatcaa tgagggtgct gccatccttc    360

ggagagagaa aaccatgata gaagtagaag ctccaatcac agtgtgtggt gacatccatg    420

gccaattttt tgatctgatg aaactttttg aagtaggagg atcacctgct aatacacgat    480

acctttttct tggcgattat gtggacagag gttattttag tatagagtgt gtcttatatt    540

tatgggttct gaagattcta tacccaagca cattatttct tctgagaggc aaccatgaat    600

gcagacacct tactgaatat tttaccttta agcaggaatg taaaattaag tattcggaaa    660

gagtctatga agcttgtatg gaagcttttg atagtttgcc tcttgctgca cttttaaacc    720

aacagtttct ttgtgttcat ggtggacttt caccagaaat acacacactg gatgatatta    780

ggagattaga tagattcaaa gagccacctg catttggacc aatgtgtgac ttgttatggt    840

ccgatccttc tgaagatttt ggaaatgaaa aatcacagga acattttagt cacaatacag    900

ttcgaggatg ttcttatttt tataactatc cagcagtgtg tgaatttttg caaaacaata    960

atttgttatc gattattaga gctcatgaag ctcaagatgc aggctataga atgtacagaa   1020

aaagtcaaac tacagggttc ccttcattaa taacaatttt ttcggcacct aattacttag   1080

atgtctacaa taataaagct gctgtattaa agtatgaaaa taatgtgatg aatattcgac   1140

agtttaactg ttctccacat ccttactggt tgcctaattt tatggatgtc ttcacgtggt   1200

ctttaccgtt tgttggagaa aaagtgacag aaatgttggt aaatgttctg agtatttgct   1260

ctgatgatga actaatgact gaaggtgaag accagtttga tggttcagct gcagcccgga   1320

aagaaatcat aagaaacaaa attcgagcaa ttggcaagat ggcaagagtc ttctctgttc   1380

tcagggagga gagtgaaagt gtgctgacac tcaagggcct gactcccaca gggatgttgc   1440

ctagtggagt gttagctgga ggacggcaga ccctgcaaag tgccacagtt gaggctattg   1500

aggctgaaaa agcaatacga ggattctctc caccacatag aatctgcagt tttgaagagg   1560

caaagggttt ggataggatc aatgagagaa tgccacctcg gaaagatgct gtacagcaag   1620

atggtttcaa ttctctgaac accgcacatg ccactgagaa ccacgggacg ggcaaccata   1680

ctgcccagtg acccactact tcccagggac tctcacatct cgggccccaa atggacagat   1740

cacccgagga gctggagggg tcggccaagc tgactgtaaa tttcacagtc tctctgaaga   1800

aaccattgtg cttctgagac cctagccccc ttcctggatg gaggcttgag ggccctggga   1860

catgtgctat ctgataagat tgggtcatcg ctgccaaggt ggagagcagt gagcaagggg   1920

cttggggcaa tttccagtgg agggcatcca cacctccatt ttatgcttgt ggttcacaca   1980

tttaagttta caaatcagat ttcttttccc cttcagtaga attagatttt gtttttcaat   2040

catgatttca aatgcaatcc taagagctaa tgtggacttt tctttttcca tgaaatgtct   2100

ttaaaggatg aattagcatg gtcttaaaat acatttctga ggttactagc tgtattttga   2160

attgtgagca aaatgccgag aaacccagtt ggcatttata caaaatgttg acctcaggtc   2220

tatagttctt aaatgtggct aattctgtaa catagtcttg gtatttttta attatgaatg   2280

catatcctat ttccaggcag gctctcttac ttgaacacaa atccaaaaac taatttagag   2340

tcttttttgc ccagatcttt taagacttac accccagaga tttaagaaga aaacctctaa   2400

atttcaaaat tatgaagaat tacagaatta ctcatttaag gtactttaaa agaagtttgt   2460

acattgtcaa agtaaatttt aattcaaatc atgtctgtaa aacttgacgt attttgtgta   2520

tgcatgtttt cattttgcaa atatttaata tatagaccta tgatgtacag gtacgacatg   2580

tataggttac ctagatgtta tgagaaattt tagtttattg tgagtactca agttgcttag   2640

agagccacca gggtgatttg ctgctggctt tctatcattt ttatgtttta atgcaaagga   2700

aattttaaaa tgttctggaa gtgtttttga ttaagcaatg cagcctagaa gcaatggttc   2760

tgttcaatca ttcagatgtt agtggaagca taaaagtcaa gactgcatgt tgaaaccttt   2820

cttttgatag ttactgaact gcttggttaa actaaatgga accatgtgct aatttttcac   2880

aattattgac ctgtattgat tgccactgta gtttggtatt tccctttact ttggtggcct   2940

gcttccctca tgccctggaa tacaactcag agctccaggc agcggaacca tctattgttt   3000

tgtttgccag aaagtgcacc ctgtatggtc tcctgtctaa gttggaaata ttatgcatgt   3060

gcaggactat tcgagtatt                                                3079


<210>  2553
<211>  524
<212>  PRT
<213>  Homosapiens

<400>  2553

Met Ala Ala Pro Glu Pro Ala Arg Ala Ala Pro Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Gly Ala Asp Arg Val Val Lys Ala Val Pro Phe 
            20                  25                  30          


Pro Pro Thr His Arg Leu Thr Ser Glu Glu Val Phe Asp Leu Asp Gly 
        35                  40                  45              


Ile Pro Arg Val Asp Val Leu Lys Asn His Leu Val Lys Glu Gly Arg 
    50                  55                  60                  


Val Asp Glu Glu Ile Ala Leu Arg Ile Ile Asn Glu Gly Ala Ala Ile 
65                  70                  75                  80  


Leu Arg Arg Glu Lys Thr Met Ile Glu Val Glu Ala Pro Ile Thr Val 
                85                  90                  95      


Cys Gly Asp Ile His Gly Gln Phe Phe Asp Leu Met Lys Leu Phe Glu 
            100                 105                 110         


Val Gly Gly Ser Pro Ala Asn Thr Arg Tyr Leu Phe Leu Gly Asp Tyr 
        115                 120                 125             


Val Asp Arg Gly Tyr Phe Ser Ile Glu Cys Val Leu Tyr Leu Trp Val 
    130                 135                 140                 


Leu Lys Ile Leu Tyr Pro Ser Thr Leu Phe Leu Leu Arg Gly Asn His 
145                 150                 155                 160 


Glu Cys Arg His Leu Thr Glu Tyr Phe Thr Phe Lys Gln Glu Cys Lys 
                165                 170                 175     


Ile Lys Tyr Ser Glu Arg Val Tyr Glu Ala Cys Met Glu Ala Phe Asp 
            180                 185                 190         


Ser Leu Pro Leu Ala Ala Leu Leu Asn Gln Gln Phe Leu Cys Val His 
        195                 200                 205             


Gly Gly Leu Ser Pro Glu Ile His Thr Leu Asp Asp Ile Arg Arg Leu 
    210                 215                 220                 


Asp Arg Phe Lys Glu Pro Pro Ala Phe Gly Pro Met Cys Asp Leu Leu 
225                 230                 235                 240 


Trp Ser Asp Pro Ser Glu Asp Phe Gly Asn Glu Lys Ser Gln Glu His 
                245                 250                 255     


Phe Ser His Asn Thr Val Arg Gly Cys Ser Tyr Phe Tyr Asn Tyr Pro 
            260                 265                 270         


Ala Val Cys Glu Phe Leu Gln Asn Asn Asn Leu Leu Ser Ile Ile Arg 
        275                 280                 285             


Ala His Glu Ala Gln Asp Ala Gly Tyr Arg Met Tyr Arg Lys Ser Gln 
    290                 295                 300                 


Thr Thr Gly Phe Pro Ser Leu Ile Thr Ile Phe Ser Ala Pro Asn Tyr 
305                 310                 315                 320 


Leu Asp Val Tyr Asn Asn Lys Ala Ala Val Leu Lys Tyr Glu Asn Asn 
                325                 330                 335     


Val Met Asn Ile Arg Gln Phe Asn Cys Ser Pro His Pro Tyr Trp Leu 
            340                 345                 350         


Pro Asn Phe Met Asp Val Phe Thr Trp Ser Leu Pro Phe Val Gly Glu 
        355                 360                 365             


Lys Val Thr Glu Met Leu Val Asn Val Leu Ser Ile Cys Ser Asp Asp 
    370                 375                 380                 


Glu Leu Met Thr Glu Gly Glu Asp Gln Phe Asp Gly Ser Ala Ala Ala 
385                 390                 395                 400 


Arg Lys Glu Ile Ile Arg Asn Lys Ile Arg Ala Ile Gly Lys Met Ala 
                405                 410                 415     


Arg Val Phe Ser Val Leu Arg Glu Glu Ser Glu Ser Val Leu Thr Leu 
            420                 425                 430         


Lys Gly Leu Thr Pro Thr Gly Met Leu Pro Ser Gly Val Leu Ala Gly 
        435                 440                 445             


Gly Arg Gln Thr Leu Gln Ser Ala Thr Val Glu Ala Ile Glu Ala Glu 
    450                 455                 460                 


Lys Ala Ile Arg Gly Phe Ser Pro Pro His Arg Ile Cys Ser Phe Glu 
465                 470                 475                 480 


Glu Ala Lys Gly Leu Asp Arg Ile Asn Glu Arg Met Pro Pro Arg Lys 
                485                 490                 495     


Asp Ala Val Gln Gln Asp Gly Phe Asn Ser Leu Asn Thr Ala His Ala 
            500                 505                 510         


Thr Glu Asn His Gly Thr Gly Asn His Thr Ala Gln 
        515                 520                 


<210>  2554
<211>  4773
<212>  DNA
<213>  Homosapiens

<400>  2554
taacaatagc agagcaagac tgacaacaat aattaaaata agagaataaa gaagatgtag     60

tcagaggcca ttctgaatgc attcagattc tcagtgtgta tgaggaaggc tgcctgtaat    120

taagagggaa tctttaacca gtttcagtgt agtagtgaaa aagtgcttcc atctgacact    180

ctccgcagtg ctctggcaaa gactttccag gatgaacaac gtttccagct gggaattatg    240

gatgatgctg cagagtgctt tgaaaacctc ctgatgagaa ttcacttcca cattgctgat    300

gaaaccaaag aggatatatg tactgcccaa cactgcattt cccatcagaa atttgcaatg    360

acattgtttg agcagtgtgt atgtactagc tgtggtgcca cttctgatcc gctgcctttc    420

atccagatgg tacattatat ctccaccact tccctttgca atcaggctat ttgtatgctg    480

gaaagacgag agaaaccttc accaagcatg tttggtgagc tgctgcagaa tgccagcacc    540

atgggggatc tgcggaactg tccaagcaac tgtggagaga ggatcaggat tcgccgtgtg    600

ttgatgaatg ctccacagat tatcacgatt gggctggtat gggactcaga ccactcagac    660

ttagcagaag atgttatcca cagcctggga acctgcctta agctgggtga tctgtttttc    720

agagtgacgg atgaccgggc caagcaatct gaactgtact tagttggaat gatctgttac    780

tatggcaaac attattctac attctttttt caaacaaaga ttcgcaaatg gatgtatttt    840

gatgatgctc atgtcaagga gattgggccc aaatggaagg atgtggtgac caaatgcatc    900

aaggggcatt atcagcccct gctgctgctt tatgcagatc cccagggtac cccagtttcc    960

acccaggacc tgcctcccca agctgagttc cagtcataca gcaggacatg ctacgacagt   1020

gaagattcag gacacctgac tgatagtgaa tgtaatcaga aacacacatc caagaaaggg   1080

tcactgatag agcgcaagag gagctctggt cgggttagga ggaaaggcga tgagccccag   1140

gcctcgggat accacagtga aggagaaaca ctgaaagaga agcaggctcc tagaaatgcc   1200

tccaaaccat ccagcagcac caacaggctg agagatttta aagagacagt cagcaatatg   1260

atccataaca gaccatccct ggcttctcag accaatgtag gctctcactg caggggcaga   1320

ggaggagacc agcctgacaa aaaacctcct aggaccctgc ctttacactc tcgtgactgg   1380

gaaatagaga gtaccagcag tgagtcaaaa tccagttctt ccagcaagta tcgtcccaca   1440

tggagaccca aacgagaatc tctgaatatt gacagtatct ttagtaagga caaaaggaag   1500

cactgtggct atacccagct tagccccttt tctgaggatt cagctaaaga atttatacca   1560

gatgaaccaa gcaagccacc ttcttacgac attaaatttg gtggaccaag cccccagtac   1620

aagcgctggg gcccagcacg gccaggctct caccttttag agcagcaccc ccgactaatc   1680

cagcgaatgg aatctggcta tgaaagcagt gagaggaaca gcagcagccc tgtcagcctg   1740

gatgcagccc tgcctgagag ctcaaatgtc tacagggatc caagtgctaa gagatcagct   1800

gggttggttc cttcctggcg tcatatccca aagtcgcaca gcagtagcat cctggaggta   1860

gactccacag catccatggg tggctggaca aagagtcagc ctttctctgg tgaggagata   1920

tcttctaaaa gtgaactgga tgaattgcag gaagaggtgg ccaggagggc gcaggaacag   1980

gaacttcgaa gaaaacggga gaaggagtta gaggcagcga aagggtttaa ccctcatcct   2040

agccgcttca tggacttgga tgaactgcag aatcaggtga gcagcctatc ccgctccaag   2100

tattgttaag ccaagaggcc caactggaat ccggcatgga tacagagttt ggggccagtt   2160

ctttcttcca ttcacctgct tcctgccatg agtcacactc atcactatct ccagagtcat   2220

ctgccccaca gcacagctcc cccagtagat ctgccttgaa gcttctgact tcggttgaag   2280

tagacaacat tgaaccctct gcattccaca ggcaaggttt acctaaagca ccagggtgga   2340

ctgagaagaa ttctcatcat agttgggagc cattggatgc cccagagggt aagctgcaag   2400

gctctaggtg tgacaacagc agttgcagca agctccctcc acaagaagga agaggcattg   2460

ctcaagaaca gctgttccaa gaaaagaagg atcctgctaa cccctccccg gtgatgcctg   2520

gaatagccac ctctgagagg ggtgatgaac acagcctagg ctgtagtcct tcaaattcat   2580

cagctcagcc cagccttccc ctgtatagaa cctgccaccc cataatgcct gttgcttctt   2640

catttgtgct tcactgtcct gatcctgtgc agaaaactaa ccaatgcctc caaggccaaa   2700

gcctcaaaac ttcattgact ttaaaagtgg acagaggcag tgaggagacc tataggccag   2760

agtttcccag cacaaagggg cttgtccgtt ctctggctga gcagttccag aggatgcagg   2820

gtgtctccat gagggatagt acaggtttca aggatagaag tttgtcaggt agtctaagga   2880

agaactcttc cccttctgat tctaagcctc ctttctcaca gggtcaagag aaaggccact   2940

ggccatgggc aaagcaacaa tcctctctgg agggtgggga tagaccactt tcctgggaag   3000

agtccactga acattcttct cttgccttaa actctgggct gcctaatggt gaaacttcta   3060

gcggaggaca gcccaggttg gcagagccag acatatacca agagaagctg tcccaagtga   3120

gagatgttag gtctaaggat ctgggcagca gtactgactt ggggacttcc ttgcctttgg   3180

attcctgggt gaatatcaca aggttctgtg attctcagct taagcatggg gcacctaggc   3240

caggaatgaa gtcctcccct catgattccc atacgtgtgt aacctatcca gagagaaatc   3300

acatcctttt gcatccacat tggaaccaag acacagagca ggagacctca gaattggagt   3360

ctctgtatca ggccagtctt caggcttctc aagctggctg ttctggatgg gggcagcagg   3420

ataccgcctg gcacccactt agccaaacag gctctgcaga tggcatgggg aggaggttgc   3480

actcagccca tgatcctggt ctctcaaaga cttcaacagc agaaatggag catggtctcc   3540

atgaagccag aacagctaca ccttgccgag gcctcagcag ggagtgtggg gaggatgagc   3600

agtacagtgc agagaattta cgtcgcatct cacgcagtct cagtggcacc gttgtctcag   3660

agagggagga agctccggtt tcttcccaca gttttgattc atcaaacgtg aggaagcctt   3720

tggaaaccgg gcaccgttgt tccagctcct cttccctccc tgtcatccat gacccttctg   3780

tgtttctcct cggtccccaa ctctaccttc cccaaccaca gttcctgtcc ccagatgtcc   3840

tgatgcccac catggcaggg gagcccaata gactcccagg aacttcaagg agtgtccagc   3900

agtttctggc tatgtgtgac aggggtgaaa cttcccaagg ggccaagtac acaggaagga   3960

ctttgaacta ccagagcctc ccccatcgct ccagaacaga caactcctgg gcaccctggt   4020

cagagaccaa ccagcatatt gggaccagat tcctgactac tccagggtgc aatcctcaac   4080

taacctacac tgccacacta ccagaaagaa gcaagggcct tcaggttcct cacactcagt   4140

cctggagtga tcttttccat tcaccctccc accctcccat tgttcatcct gtgtacccac   4200

catctagcag tcttcatgta cccctgaggt cagcttggaa ttcagatcct gttccagggt   4260

cccgaacccc tggtcctcga agagtagata tgcccccaga tgatgactgg aggcaaagca   4320

gttatgcctc ccactctgga cacaggagaa cagtgggaga ggggtttctg tttgttctat   4380

cagatgctcc cagaagagag cagatcaggg ctagagtcct gcagcacagt caatggtaaa   4440

ggttattcct ttcctttcct ggagctacac ctttctttgt aaaactgtac tgtgggccgg   4500

gcgcggtggc tcacacctgt aatcccagcg ctttgggagg ctgaggcggg tggatcacga   4560

ggtcaggaga ttgagaccat cctggccaac atggtgaaac cccgtctcta ccaaaataca   4620

aaaaattagc caggcgtgac ggtgcgtgcc tgtagtccca actactcgga aggctgaggc   4680

aggagaattg cttgaacccg ggaggcagag gttgcagtga gccgagatcg caccactgca   4740

ctccagcttg gcaatagagt gagactccat ctc                                4773


<210>  2555
<211>  767
<212>  PRT
<213>  Homosapiens

<400>  2555

Met Asp Thr Glu Phe Gly Ala Ser Ser Phe Phe His Ser Pro Ala Ser 
1               5                   10                  15      


Cys His Glu Ser His Ser Ser Leu Ser Pro Glu Ser Ser Ala Pro Gln 
            20                  25                  30          


His Ser Ser Pro Ser Arg Ser Ala Leu Lys Leu Leu Thr Ser Val Glu 
        35                  40                  45              


Val Asp Asn Ile Glu Pro Ser Ala Phe His Arg Gln Gly Leu Pro Lys 
    50                  55                  60                  


Ala Pro Gly Trp Thr Glu Lys Asn Ser His His Ser Trp Glu Pro Leu 
65                  70                  75                  80  


Asp Ala Pro Glu Gly Lys Leu Gln Gly Ser Arg Cys Asp Asn Ser Ser 
                85                  90                  95      


Cys Ser Lys Leu Pro Pro Gln Glu Gly Arg Gly Ile Ala Gln Glu Gln 
            100                 105                 110         


Leu Phe Gln Glu Lys Lys Asp Pro Ala Asn Pro Ser Pro Val Met Pro 
        115                 120                 125             


Gly Ile Ala Thr Ser Glu Arg Gly Asp Glu His Ser Leu Gly Cys Ser 
    130                 135                 140                 


Pro Ser Asn Ser Ser Ala Gln Pro Ser Leu Pro Leu Tyr Arg Thr Cys 
145                 150                 155                 160 


His Pro Ile Met Pro Val Ala Ser Ser Phe Val Leu His Cys Pro Asp 
                165                 170                 175     


Pro Val Gln Lys Thr Asn Gln Cys Leu Gln Gly Gln Ser Leu Lys Thr 
            180                 185                 190         


Ser Leu Thr Leu Lys Val Asp Arg Gly Ser Glu Glu Thr Tyr Arg Pro 
        195                 200                 205             


Glu Phe Pro Ser Thr Lys Gly Leu Val Arg Ser Leu Ala Glu Gln Phe 
    210                 215                 220                 


Gln Arg Met Gln Gly Val Ser Met Arg Asp Ser Thr Gly Phe Lys Asp 
225                 230                 235                 240 


Arg Ser Leu Ser Gly Ser Leu Arg Lys Asn Ser Ser Pro Ser Asp Ser 
                245                 250                 255     


Lys Pro Pro Phe Ser Gln Gly Gln Glu Lys Gly His Trp Pro Trp Ala 
            260                 265                 270         


Lys Gln Gln Ser Ser Leu Glu Gly Gly Asp Arg Pro Leu Ser Trp Glu 
        275                 280                 285             


Glu Ser Thr Glu His Ser Ser Leu Ala Leu Asn Ser Gly Leu Pro Asn 
    290                 295                 300                 


Gly Glu Thr Ser Ser Gly Gly Gln Pro Arg Leu Ala Glu Pro Asp Ile 
305                 310                 315                 320 


Tyr Gln Glu Lys Leu Ser Gln Val Arg Asp Val Arg Ser Lys Asp Leu 
                325                 330                 335     


Gly Ser Ser Thr Asp Leu Gly Thr Ser Leu Pro Leu Asp Ser Trp Val 
            340                 345                 350         


Asn Ile Thr Arg Phe Cys Asp Ser Gln Leu Lys His Gly Ala Pro Arg 
        355                 360                 365             


Pro Gly Met Lys Ser Ser Pro His Asp Ser His Thr Cys Val Thr Tyr 
    370                 375                 380                 


Pro Glu Arg Asn His Ile Leu Leu His Pro His Trp Asn Gln Asp Thr 
385                 390                 395                 400 


Glu Gln Glu Thr Ser Glu Leu Glu Ser Leu Tyr Gln Ala Ser Leu Gln 
                405                 410                 415     


Ala Ser Gln Ala Gly Cys Ser Gly Trp Gly Gln Gln Asp Thr Ala Trp 
            420                 425                 430         


His Pro Leu Ser Gln Thr Gly Ser Ala Asp Gly Met Gly Arg Arg Leu 
        435                 440                 445             


His Ser Ala His Asp Pro Gly Leu Ser Lys Thr Ser Thr Ala Glu Met 
    450                 455                 460                 


Glu His Gly Leu His Glu Ala Arg Thr Ala Thr Pro Cys Arg Gly Leu 
465                 470                 475                 480 


Ser Arg Glu Cys Gly Glu Asp Glu Gln Tyr Ser Ala Glu Asn Leu Arg 
                485                 490                 495     


Arg Ile Ser Arg Ser Leu Ser Gly Thr Val Val Ser Glu Arg Glu Glu 
            500                 505                 510         


Ala Pro Val Ser Ser His Ser Phe Asp Ser Ser Asn Val Arg Lys Pro 
        515                 520                 525             


Leu Glu Thr Gly His Arg Cys Ser Ser Ser Ser Ser Leu Pro Val Ile 
    530                 535                 540                 


His Asp Pro Ser Val Phe Leu Leu Gly Pro Gln Leu Tyr Leu Pro Gln 
545                 550                 555                 560 


Pro Gln Phe Leu Ser Pro Asp Val Leu Met Pro Thr Met Ala Gly Glu 
                565                 570                 575     


Pro Asn Arg Leu Pro Gly Thr Ser Arg Ser Val Gln Gln Phe Leu Ala 
            580                 585                 590         


Met Cys Asp Arg Gly Glu Thr Ser Gln Gly Ala Lys Tyr Thr Gly Arg 
        595                 600                 605             


Thr Leu Asn Tyr Gln Ser Leu Pro His Arg Ser Arg Thr Asp Asn Ser 
    610                 615                 620                 


Trp Ala Pro Trp Ser Glu Thr Asn Gln His Ile Gly Thr Arg Phe Leu 
625                 630                 635                 640 


Thr Thr Pro Gly Cys Asn Pro Gln Leu Thr Tyr Thr Ala Thr Leu Pro 
                645                 650                 655     


Glu Arg Ser Lys Gly Leu Gln Val Pro His Thr Gln Ser Trp Ser Asp 
            660                 665                 670         


Leu Phe His Ser Pro Ser His Pro Pro Ile Val His Pro Val Tyr Pro 
        675                 680                 685             


Pro Ser Ser Ser Leu His Val Pro Leu Arg Ser Ala Trp Asn Ser Asp 
    690                 695                 700                 


Pro Val Pro Gly Ser Arg Thr Pro Gly Pro Arg Arg Val Asp Met Pro 
705                 710                 715                 720 


Pro Asp Asp Asp Trp Arg Gln Ser Ser Tyr Ala Ser His Ser Gly His 
                725                 730                 735     


Arg Arg Thr Val Gly Glu Gly Phe Leu Phe Val Leu Ser Asp Ala Pro 
            740                 745                 750         


Arg Arg Glu Gln Ile Arg Ala Arg Val Leu Gln His Ser Gln Trp 
        755                 760                 765         


<210>  2556
<211>  1661
<212>  DNA
<213>  Homosapiens

<400>  2556
gtttctccct aagtgcttct ttggatctca ggctctaggt gcaatgtgaa ggggagtccc     60

tgggcagact gatccctggc tcagacagtt cagtgggaga atcccaaagg ccttttccct    120

ccttcctgag cctccgggca aggagggagg gatcttggtt ccagggtctc agtaccccct    180

gtgccatttg agctgcttgc gctcatcatc tctattaata accaacttcc ctcccccact    240

gccagtgctg cccccacgcc tgcccagctc gtgttctccg gtcacagcag ctcagtcctc    300

caaagctgct ggaccccagg gagagctgac cactgcccga gcagccggct gaatccacct    360

ccacaatgcc gctctcagga accccggccc ctaataagaa gaggaaatcc agcaagctga    420

tcatggaact cactggaggt ggacaggaga gctcaggctt gaacctgggc aaaaagatca    480

gtgtcccaag ggatgtgatg ttggaggaac tgtcgctgct taccaaccgg ggctccaaga    540

tgttcaaact gcggcagatg agggtggaga agtttattta tgagaaccac cctgatgttt    600

tctctgacag ctcaatggat cacttccaga agttccttcc aacagtgggg ggacagctgg    660

gcacagctgg tcagggattc tcatacagca agagcaacgg cagaggcggc agccaggcag    720

ggggcagtgg ctctgccgga cagtatggct ctgatcagca gcaccatctg ggctctgggt    780

ctggagctgg gggtacaggt ggtcccgcgg gccaggctgg cagaggagga gctgctggca    840

cagcaggggt tggtgagaca ggatcaggag accaggcagg cggagaagga aaacatatca    900

ctgtgttcaa gacctatatt tccccatggg agcgagccat gggggttgac ccccagcaaa    960

aaatggaact tggcattgac ctgctggcct atggggccaa agctgaactt cccaaatata   1020

agtccttcaa caggacggca atgccctatg gtggatatga gaaggcctcc aaacgcatga   1080

ccttccagat gcccaagttt gacctggggc ccttgctgag tgaacccctg gtcctctaca   1140

accaaaacct ctccaacagg ccttctttca atcgaacccc tattccctgg ctgagctctg   1200

gggagcctgt agactacaac gtggatattg gcatcccctt ggatggagaa acagaggagc   1260

tgtgaggtgt ttcctcctct gatttgcatc atttcccctc tctggctcca atttggagag   1320

ggaatgctga gcagatagcc cccattgtta atccagtatc cttatgggaa tggagggaaa   1380

aaggagagat ctacctttcc atcctttact ccaagtcccc actccacgca tccttcctca   1440

ccaactcaga gctccccttc tacttgctcc atatggaacc tgctcgttta tggaatttgc   1500

tctgccacca gtaacagtca ataaacttca aggaaaatga aaaaaaaaaa aaaaaaaaaa   1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       1661


<210>  2557
<211>  299
<212>  PRT
<213>  Homosapiens

<400>  2557

Met Pro Leu Ser Gly Thr Pro Ala Pro Asn Lys Lys Arg Lys Ser Ser 
1               5                   10                  15      


Lys Leu Ile Met Glu Leu Thr Gly Gly Gly Gln Glu Ser Ser Gly Leu 
            20                  25                  30          


Asn Leu Gly Lys Lys Ile Ser Val Pro Arg Asp Val Met Leu Glu Glu 
        35                  40                  45              


Leu Ser Leu Leu Thr Asn Arg Gly Ser Lys Met Phe Lys Leu Arg Gln 
    50                  55                  60                  


Met Arg Val Glu Lys Phe Ile Tyr Glu Asn His Pro Asp Val Phe Ser 
65                  70                  75                  80  


Asp Ser Ser Met Asp His Phe Gln Lys Phe Leu Pro Thr Val Gly Gly 
                85                  90                  95      


Gln Leu Gly Thr Ala Gly Gln Gly Phe Ser Tyr Ser Lys Ser Asn Gly 
            100                 105                 110         


Arg Gly Gly Ser Gln Ala Gly Gly Ser Gly Ser Ala Gly Gln Tyr Gly 
        115                 120                 125             


Ser Asp Gln Gln His His Leu Gly Ser Gly Ser Gly Ala Gly Gly Thr 
    130                 135                 140                 


Gly Gly Pro Ala Gly Gln Ala Gly Arg Gly Gly Ala Ala Gly Thr Ala 
145                 150                 155                 160 


Gly Val Gly Glu Thr Gly Ser Gly Asp Gln Ala Gly Gly Glu Gly Lys 
                165                 170                 175     


His Ile Thr Val Phe Lys Thr Tyr Ile Ser Pro Trp Glu Arg Ala Met 
            180                 185                 190         


Gly Val Asp Pro Gln Gln Lys Met Glu Leu Gly Ile Asp Leu Leu Ala 
        195                 200                 205             


Tyr Gly Ala Lys Ala Glu Leu Pro Lys Tyr Lys Ser Phe Asn Arg Thr 
    210                 215                 220                 


Ala Met Pro Tyr Gly Gly Tyr Glu Lys Ala Ser Lys Arg Met Thr Phe 
225                 230                 235                 240 


Gln Met Pro Lys Phe Asp Leu Gly Pro Leu Leu Ser Glu Pro Leu Val 
                245                 250                 255     


Leu Tyr Asn Gln Asn Leu Ser Asn Arg Pro Ser Phe Asn Arg Thr Pro 
            260                 265                 270         


Ile Pro Trp Leu Ser Ser Gly Glu Pro Val Asp Tyr Asn Val Asp Ile 
        275                 280                 285             


Gly Ile Pro Leu Asp Gly Glu Thr Glu Glu Leu 
    290                 295                 


<210>  2558
<211>  3470
<212>  DNA
<213>  Homosapiens

<400>  2558
agccaacacc gcctttctca gcatggagac ctttgagccc atcagccaag agcccctcag     60

ccaagccagc tatgacaaag ccccagaccc agttcctgag ctccaagact cgttctatgc    120

agaactgcaa cgtgcagaga gcctccaaga gaagagcata aaagaggcca agaccaaatg    180

caggacaatt gcatccctgc tcactgcagc ccccaacccc cactccaaag gggtacttat    240

gtttaagaaa cggcggcaga gagccaagaa gtacaccctg gtgagcttcg gggctgctgc    300

tgggacaggc gctgaggagg aggacggcgt tccccccacg agtgagtccg agctggacga    360

agaagccttc tctgacgccc gcagcctcac caatcaatct gactgggaca gtccctatct    420

ggacatggag cttgccaggg cgggctcaag agcatcagag ggccagggct ctgggctggg    480

agggcagctg agtgaggtct ctgggcgagg ggtgcagctc tttgaacagc agcgccagcg    540

cgcagactcc agcacccagg aactggcacg ggtcgaacca gcagccatgc tcaacgggga    600

aggcctgcag tcaccacctc gggcccagag tgctccccca gaggcagctg tgctcccacc    660

cagccccttg ccggcgcctg tagccagccc cagacccttc caaccaggtg gtggagcccc    720

gaccccagct ccaagcatct ttaaccggtc agccaggccc tttaccccgg gcctacaagg    780

gcagcggcca actaccacct cggttatttt ccggccttta gcccccaaaa gggcgaacga    840

cagcctgggg ggcctcagcc ccgccccacc ccccttcttg tcttcgcagg ggcccacccc    900

tctgcccagc ttcacttcag gggttcccag ccacgcgcca gtctctggtt cccccagcac    960

cccacgctcc tcgggccctg tgacagccac cagctccctg tacatcccag cccctagtcg   1020

gcctgtcacc ccaggtggag ctccagagcc ccccgctcct cctagcgcag ctgccatgac   1080

ctccaccgct tctatcttcc tatctgcgcc tttgcgaccc tctgcgcgcc cagaggcgcc   1140

tgccccaggc ccaggggctc ctgagccccc cagcgctcgc gagcagcgca tctctgtgcc   1200

agctgcccgc acgggtatcc tgcaggaggc ccggcgccgg gggacccgga agcagatgtt   1260

ccggccggga aaggaggaga cgaagaactc gcccaacccc gagctgctat cgctggtaca   1320

gaacctggat gaaaagcctc gggccggggg tgcagaatct ggtcctgaag aagatgctct   1380

gagcctcggg gctgaagcct gcaacttcat gcagccagta ggggccagga gttacaagac   1440

cctgcctcac gtgacaccta agaccccccc tccaatggct cccaagaccc cgccccctat   1500

gactcctaag actccacccc cagtggctcc taagccccca tctcgagggc tccttgatgg   1560

gctcgtgaat ggggcagcct cttcggctgg aatccctgag ccaccaaggc tgcagggcag   1620

gggtggggag ctgtttgcta agcggcagag ccgtgcggac aggtatgtgg tggaaggtac   1680

acctggtcct ggtcttggcc ctcggcctag aagtccttct cctaccccgt ctctgccccc   1740

ttcctggaaa tattcaccca acatccgtgc cccgcctcct attgcttaca acccactgct   1800

ctctcccttt ttcccccagg cggcccgaac tctccctaag gcccaatccc aggggcctcg   1860

ggcaacaccc aagcagggca tcaaggctct agattttatg cggcatcagc cctatcaact   1920

taaaactgcc atgttctgtt ttgatgaggt tcccccgact cctggcccta tcgcctcagg   1980

gtcccccaaa actgcccgag tccaggagat tcgccggttt tccactccgg caccccagcc   2040

cactgcagaa cccctggctc ccactgtgct tgccccccga gcagccacta cactggatga   2100

gcccatctgg agaacagaac tggcctcagc ccctgttcct agcccagccc ctcctccaga   2160

ggctcccagg ggccttgggg cttctcccag ctcctgcggt ttccaggtag ccaggccccg   2220

attttcagcc accagaacag gattgcaagc tcatgtgtgg aggcctgggg cagggcacca   2280

gtgaacaggc acaggtccca ggaccaagga gaggtggaac atccagttcc taaagttgct   2340

tctcctaccc tatcccatcc cctgtcacgc atctggaagc taaattgcct cctgccagag   2400

atggtttcca agttgatgtc cccttccccc accttcctcc tcactctcta cctccctgcc   2460

gctttccaac caagtatgtc tgctttggta tctttgcctc tctttgtctc tgcatttcct   2520

ttcctggatc tctgtcttta tttccaggct tctccaccca tattcctcca cagatctctc   2580

ttccttgaca tttgtgcttt tctccctggg cctcatttta atgttcagtg agaagtaaac   2640

agagcagaag tgaccactgg gacttcaggc aagaagctca ccaccaggca cacagcaaag   2700

ggactgaact gacccctgtt tgcactaagc cacccccacc ccccactctg ctttcccaag   2760

cttgactggc atatacctag gcctgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt   2820

gtgctcttcc gtctaaggca tgaataagag gggaggtcaa aataaagacc caatctgagg   2880

ccgggcacgg tggctcacgc cggtaatccc agcactttgg gaggccgagg cgggcggatc   2940

acgaggtcag gagatcgaga ccatcctggc taacacggtg aaaccccatt tccactaaaa   3000

atacaaaaaa ttagctgggc gtggtggcga gcgcctgtag tcccagctac tcgggaggct   3060

gaggcaggag aatggcatga acctggaagg cggagcttgc agtgagctga gattgcgcca   3120

ctgcactcca gcctgggcga cggagcgaga ctctgtctca aaacaaacaa acaaacaaaa   3180

gacccaatct gagtcttatc gttgtactga tagaagggtc agatatcccc acatggagtt   3240

gagtgggaga aagagattca ctagagaata actccttaga gaccaatgtc tgtagcaggt   3300

gtacagcatc ttgtgaaagt tatggagcat gaaaagactg aagggccagg acagtttgca   3360

tgggctgagt tataccagct agaccaggaa tagaacaaag aattctatac ctcaggattt   3420

caaaaagtta gcaacttgag aggccagtgc tgagcaaccc agtacccagg              3470


<210>  2559
<211>  753
<212>  PRT
<213>  Homosapiens

<400>  2559

Met Glu Thr Phe Glu Pro Ile Ser Gln Glu Pro Leu Ser Gln Ala Ser 
1               5                   10                  15      


Tyr Asp Lys Ala Pro Asp Pro Val Pro Glu Leu Gln Asp Ser Phe Tyr 
            20                  25                  30          


Ala Glu Leu Gln Arg Ala Glu Ser Leu Gln Glu Lys Ser Ile Lys Glu 
        35                  40                  45              


Ala Lys Thr Lys Cys Arg Thr Ile Ala Ser Leu Leu Thr Ala Ala Pro 
    50                  55                  60                  


Asn Pro His Ser Lys Gly Val Leu Met Phe Lys Lys Arg Arg Gln Arg 
65                  70                  75                  80  


Ala Lys Lys Tyr Thr Leu Val Ser Phe Gly Ala Ala Ala Gly Thr Gly 
                85                  90                  95      


Ala Glu Glu Glu Asp Gly Val Pro Pro Thr Ser Glu Ser Glu Leu Asp 
            100                 105                 110         


Glu Glu Ala Phe Ser Asp Ala Arg Ser Leu Thr Asn Gln Ser Asp Trp 
        115                 120                 125             


Asp Ser Pro Tyr Leu Asp Met Glu Leu Ala Arg Ala Gly Ser Arg Ala 
    130                 135                 140                 


Ser Glu Gly Gln Gly Ser Gly Leu Gly Gly Gln Leu Ser Glu Val Ser 
145                 150                 155                 160 


Gly Arg Gly Val Gln Leu Phe Glu Gln Gln Arg Gln Arg Ala Asp Ser 
                165                 170                 175     


Ser Thr Gln Glu Leu Ala Arg Val Glu Pro Ala Ala Met Leu Asn Gly 
            180                 185                 190         


Glu Gly Leu Gln Ser Pro Pro Arg Ala Gln Ser Ala Pro Pro Glu Ala 
        195                 200                 205             


Ala Val Leu Pro Pro Ser Pro Leu Pro Ala Pro Val Ala Ser Pro Arg 
    210                 215                 220                 


Pro Phe Gln Pro Gly Gly Gly Ala Pro Thr Pro Ala Pro Ser Ile Phe 
225                 230                 235                 240 


Asn Arg Ser Ala Arg Pro Phe Thr Pro Gly Leu Gln Gly Gln Arg Pro 
                245                 250                 255     


Thr Thr Thr Ser Val Ile Phe Arg Pro Leu Ala Pro Lys Arg Ala Asn 
            260                 265                 270         


Asp Ser Leu Gly Gly Leu Ser Pro Ala Pro Pro Pro Phe Leu Ser Ser 
        275                 280                 285             


Gln Gly Pro Thr Pro Leu Pro Ser Phe Thr Ser Gly Val Pro Ser His 
    290                 295                 300                 


Ala Pro Val Ser Gly Ser Pro Ser Thr Pro Arg Ser Ser Gly Pro Val 
305                 310                 315                 320 


Thr Ala Thr Ser Ser Leu Tyr Ile Pro Ala Pro Ser Arg Pro Val Thr 
                325                 330                 335     


Pro Gly Gly Ala Pro Glu Pro Pro Ala Pro Pro Ser Ala Ala Ala Met 
            340                 345                 350         


Thr Ser Thr Ala Ser Ile Phe Leu Ser Ala Pro Leu Arg Pro Ser Ala 
        355                 360                 365             


Arg Pro Glu Ala Pro Ala Pro Gly Pro Gly Ala Pro Glu Pro Pro Ser 
    370                 375                 380                 


Ala Arg Glu Gln Arg Ile Ser Val Pro Ala Ala Arg Thr Gly Ile Leu 
385                 390                 395                 400 


Gln Glu Ala Arg Arg Arg Gly Thr Arg Lys Gln Met Phe Arg Pro Gly 
                405                 410                 415     


Lys Glu Glu Thr Lys Asn Ser Pro Asn Pro Glu Leu Leu Ser Leu Val 
            420                 425                 430         


Gln Asn Leu Asp Glu Lys Pro Arg Ala Gly Gly Ala Glu Ser Gly Pro 
        435                 440                 445             


Glu Glu Asp Ala Leu Ser Leu Gly Ala Glu Ala Cys Asn Phe Met Gln 
    450                 455                 460                 


Pro Val Gly Ala Arg Ser Tyr Lys Thr Leu Pro His Val Thr Pro Lys 
465                 470                 475                 480 


Thr Pro Pro Pro Met Ala Pro Lys Thr Pro Pro Pro Met Thr Pro Lys 
                485                 490                 495     


Thr Pro Pro Pro Val Ala Pro Lys Pro Pro Ser Arg Gly Leu Leu Asp 
            500                 505                 510         


Gly Leu Val Asn Gly Ala Ala Ser Ser Ala Gly Ile Pro Glu Pro Pro 
        515                 520                 525             


Arg Leu Gln Gly Arg Gly Gly Glu Leu Phe Ala Lys Arg Gln Ser Arg 
    530                 535                 540                 


Ala Asp Arg Tyr Val Val Glu Gly Thr Pro Gly Pro Gly Leu Gly Pro 
545                 550                 555                 560 


Arg Pro Arg Ser Pro Ser Pro Thr Pro Ser Leu Pro Pro Ser Trp Lys 
                565                 570                 575     


Tyr Ser Pro Asn Ile Arg Ala Pro Pro Pro Ile Ala Tyr Asn Pro Leu 
            580                 585                 590         


Leu Ser Pro Phe Phe Pro Gln Ala Ala Arg Thr Leu Pro Lys Ala Gln 
        595                 600                 605             


Ser Gln Gly Pro Arg Ala Thr Pro Lys Gln Gly Ile Lys Ala Leu Asp 
    610                 615                 620                 


Phe Met Arg His Gln Pro Tyr Gln Leu Lys Thr Ala Met Phe Cys Phe 
625                 630                 635                 640 


Asp Glu Val Pro Pro Thr Pro Gly Pro Ile Ala Ser Gly Ser Pro Lys 
                645                 650                 655     


Thr Ala Arg Val Gln Glu Ile Arg Arg Phe Ser Thr Pro Ala Pro Gln 
            660                 665                 670         


Pro Thr Ala Glu Pro Leu Ala Pro Thr Val Leu Ala Pro Arg Ala Ala 
        675                 680                 685             


Thr Thr Leu Asp Glu Pro Ile Trp Arg Thr Glu Leu Ala Ser Ala Pro 
    690                 695                 700                 


Val Pro Ser Pro Ala Pro Pro Pro Glu Ala Pro Arg Gly Leu Gly Ala 
705                 710                 715                 720 


Ser Pro Ser Ser Cys Gly Phe Gln Val Ala Arg Pro Arg Phe Ser Ala 
                725                 730                 735     


Thr Arg Thr Gly Leu Gln Ala His Val Trp Arg Pro Gly Ala Gly His 
            740                 745                 750         


Gln 
    


<210>  2560
<211>  3263
<212>  DNA
<213>  Homosapiens

<400>  2560
gtcgggggcc gaagcgcctc ccgcagggag tccccgtgag gccgcgctgc cgcgttaccc     60

gcagcggccg ggggtccggg gagtgcgggg ctccgagaca gagccaggcg ccccccagcg    120

gtcggcgcgg gccccatggc tgggccgggc ggagcggaac cggtgaggtg aagccccggg    180

gccggcagcc ggaggcgcgt ggccggggcg ccggctccat gggcagcggc acacggcggc    240

gcgatgatgg acgttaacag cagcggccgc ccggacctct acgggcacct ccgctctttc    300

cttctgccag aagtggggcg cgggctgccc gacttgagcc ccgacggtgg cgccgacccg    360

gtcgcgggct cctgggcgcc gcacctgctg agcgaggtga cagccagccc ggcgcccacc    420

tgggacgcgc ccccggacaa tgcctccggc tgtggggaac agatcaacta cggcagagtc    480

gagaaagttg tgatcggctc catcctgacg ctcatcacgc tgctgacgat cgcgggcaac    540

tgcctggtgg tgatctccgt gtgcttcgtc aagaagctcc gccagccctc caactacctg    600

atcgtgtccc tggcgctggc cgacctctcg gtggctgtgg cggtcatgcc cttcgtcagc    660

gtcaccgacc tcatcggggg caagtggatc tttggacact ttttctgtaa tgtcttcatc    720

gccatggacg tcatgtgctg cacggcctcg atcatgaccc tgtgcgtgat cagcattgac    780

aggtaccttg ggatcacaag gcccctcaca taccctgtga ggcagaatgg gaaatgcatg    840

gcgaagatga ttctctccgt ctggcttctc tccgcctcca tcaccttacc tccactcttt    900

ggatgggctc agaatgtaaa tgatgataag gtgtgcttga tcagccagga ctttggctat    960

acgatttact ctaccgcagt ggcattttat atccccatgt ccgtcatgct tttcatgtac   1020

taccagattt acaaggctgc caggaagagt gctgccaaac acaagtttcc tggcttccct   1080

cgagtggagc cagacagcgt catcgccctg aatggcatag tgaagctcca gaaggaggtg   1140

gaagagtgtg caaacctttc gagactcctc aagcatgaaa ggaaaaacat ctccatcttt   1200

aagcgagaac agaaagcagc caccaccctg gggatcatcg tcggggcctt taccgtgtgc   1260

tggctgccat ttttcctcct ctcgacagcc agacccttca tctgtggcac ttcctgcagc   1320

tgcatcccac tgtgggtgga gaggacattt ctgtggctag gctatgcaaa ctctctcatt   1380

aaccctttta tatatgcctt cttcaaccgg gacctgagga ccacctatcg cagcctgctc   1440

cagtgccagt accggaatat caaccggaag ctctcagctg caggcatgca tgaagccctg   1500

aagcttgctg agaggccaga gagacctgag tttgtgctac aaaatgctga ctactgtaga   1560

aaaaaaggtc atgattcatg attgaaagca gaacaatgga gaaggaagtc atttgctgag   1620

tctgcagaat ggaatgcagc ttctgtcctt tcttgggatg tctaaaacat gacaaacagg   1680

gtgatctgtt gtacacacta tcttatgagg gagatggtga cttctccttt ttttctgtgg   1740

atcagtgcta ttgtgtgttc tcagtttaag atagcagatc atctcagcag taagcacacc   1800

aacagaactg agttccagaa aggaagcagt ttctggtgct ttgcatatgt ccaaatccat   1860

gcaagtggga gaaagttcca gtgcacactt cccatgcttc tgagtctagg cgttgtggtg   1920

aatatgcagg aatcattcat gagacagaat gtattttgtt gtatgacaga aggcttttcc   1980

aagcaaactg cggtgagcgt agtgttgaat atgttgcatg tccatgttag aaaacagaat   2040

ccagtcatca gctaatacaa atgatttccc agagcagtgt ttgtttcaag cttctgtcaa   2100

atagtttggc ttttctgcag ggtctctgtg atttccccac ctatgtactt ttctgtgtta   2160

actcacttat tatggtataa ctcaggaaca ggtctcagga tggagagaag catacaacat   2220

gagcaaagct ttttctcgtg ctctgaaggg tcttgagagg ggagtgggat gccttctgtg   2280

aggattttta tcgcagtgaa gctcaagtgg tacccaactg cgttgtaatt aacatgatta   2340

ttggcatgtt tttgactctc attttctaca aggctgcagt gggcccaccc atgggctggc   2400

ccataactgt atgttatgtg gaagaagtgt gggaatgatg ggttttccat gaaatgtgat   2460

gcttctggag atggggcata aacatgttca ttcttgttga gctgcattgt gttaaaccaa   2520

attgtgtgaa gcgaggtcac ctggaccact cttgggaaat gcttcagaac accagtctgt   2580

tccttctaga gaatttgttt ttgtgttcta tgtatcttaa atcaaatgtg tgcctaagca   2640

attctgtcct ctgattccca cccctaccca ccaaaaaatg gtagacatga aaggcaggtg   2700

aggaaacaga aaaggtctct ttgcagatat atatttttta aatggcacta tgtagtaatt   2760

aagagctaag gagacagaaa gacagtagat gagaatagaa gagtacctgt acctacaagg   2820

ggaaaaatga atgcaattct ttatttgata agagtgaact gaaagagaat attattttcc   2880

tacaataaag caagctgtcc tctcacagga taaagtggaa ttctgacatg gattatggac   2940

ttcttctaac tcccattgac attgcttctt accagacatg gggaaaagct acctttcctg   3000

aaaggggagg agggcactgt cctttcagac aaagcttgta caaattcctg aaccgcaaat   3060

ttgctgaagt gaccgtatat attatattca taatttaaat gattatttat ggtcagatac   3120

atattgttaa acttgaaaat gttttattac attacatcaa ataaagttta tttgtagctg   3180

aaataaagca acgtaagtaa caatttttaa ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3240

aaaaaaaaaa aaaaaaaaaa aaa                                           3263


<210>  2561
<211>  445
<212>  PRT
<213>  Homosapiens

<400>  2561

Met Met Asp Val Asn Ser Ser Gly Arg Pro Asp Leu Tyr Gly His Leu 
1               5                   10                  15      


Arg Ser Phe Leu Leu Pro Glu Val Gly Arg Gly Leu Pro Asp Leu Ser 
            20                  25                  30          


Pro Asp Gly Gly Ala Asp Pro Val Ala Gly Ser Trp Ala Pro His Leu 
        35                  40                  45              


Leu Ser Glu Val Thr Ala Ser Pro Ala Pro Thr Trp Asp Ala Pro Pro 
    50                  55                  60                  


Asp Asn Ala Ser Gly Cys Gly Glu Gln Ile Asn Tyr Gly Arg Val Glu 
65                  70                  75                  80  


Lys Val Val Ile Gly Ser Ile Leu Thr Leu Ile Thr Leu Leu Thr Ile 
                85                  90                  95      


Ala Gly Asn Cys Leu Val Val Ile Ser Val Cys Phe Val Lys Lys Leu 
            100                 105                 110         


Arg Gln Pro Ser Asn Tyr Leu Ile Val Ser Leu Ala Leu Ala Asp Leu 
        115                 120                 125             


Ser Val Ala Val Ala Val Met Pro Phe Val Ser Val Thr Asp Leu Ile 
    130                 135                 140                 


Gly Gly Lys Trp Ile Phe Gly His Phe Phe Cys Asn Val Phe Ile Ala 
145                 150                 155                 160 


Met Asp Val Met Cys Cys Thr Ala Ser Ile Met Thr Leu Cys Val Ile 
                165                 170                 175     


Ser Ile Asp Arg Tyr Leu Gly Ile Thr Arg Pro Leu Thr Tyr Pro Val 
            180                 185                 190         


Arg Gln Asn Gly Lys Cys Met Ala Lys Met Ile Leu Ser Val Trp Leu 
        195                 200                 205             


Leu Ser Ala Ser Ile Thr Leu Pro Pro Leu Phe Gly Trp Ala Gln Asn 
    210                 215                 220                 


Val Asn Asp Asp Lys Val Cys Leu Ile Ser Gln Asp Phe Gly Tyr Thr 
225                 230                 235                 240 


Ile Tyr Ser Thr Ala Val Ala Phe Tyr Ile Pro Met Ser Val Met Leu 
                245                 250                 255     


Phe Met Tyr Tyr Gln Ile Tyr Lys Ala Ala Arg Lys Ser Ala Ala Lys 
            260                 265                 270         


His Lys Phe Pro Gly Phe Pro Arg Val Glu Pro Asp Ser Val Ile Ala 
        275                 280                 285             


Leu Asn Gly Ile Val Lys Leu Gln Lys Glu Val Glu Glu Cys Ala Asn 
    290                 295                 300                 


Leu Ser Arg Leu Leu Lys His Glu Arg Lys Asn Ile Ser Ile Phe Lys 
305                 310                 315                 320 


Arg Glu Gln Lys Ala Ala Thr Thr Leu Gly Ile Ile Val Gly Ala Phe 
                325                 330                 335     


Thr Val Cys Trp Leu Pro Phe Phe Leu Leu Ser Thr Ala Arg Pro Phe 
            340                 345                 350         


Ile Cys Gly Thr Ser Cys Ser Cys Ile Pro Leu Trp Val Glu Arg Thr 
        355                 360                 365             


Phe Leu Trp Leu Gly Tyr Ala Asn Ser Leu Ile Asn Pro Phe Ile Tyr 
    370                 375                 380                 


Ala Phe Phe Asn Arg Asp Leu Arg Thr Thr Tyr Arg Ser Leu Leu Gln 
385                 390                 395                 400 


Cys Gln Tyr Arg Asn Ile Asn Arg Lys Leu Ser Ala Ala Gly Met His 
                405                 410                 415     


Glu Ala Leu Lys Leu Ala Glu Arg Pro Glu Arg Pro Glu Phe Val Leu 
            420                 425                 430         


Gln Asn Ala Asp Tyr Cys Arg Lys Lys Gly His Asp Ser 
        435                 440                 445 


<210>  2562
<211>  3396
<212>  DNA
<213>  Homosapiens

<400>  2562
gtcgggggcc gaagcgcctc ccgcagggag tccccgtgag gccgcgctgc cgcgttaccc     60

gcagcggccg ggggtccggg gagtgcgggg ctccgagaca gagccaggcg ccccccagcg    120

gtcggcgcgg gccccatggc tgggccgggc ggagcggaac cggtgaggtg aagccccggg    180

gccggcagcc ggaggcgcgt ggccggggcg ccggctccat gggcagcggc acacggcggc    240

gcgatgatgg acgttaacag cagcggccgc ccggacctct acgggcacct ccgctctttc    300

cttctgccag aagtggggcg cgggctgccc gacttgagcc ccgacggtgg cgccgacccg    360

gtcgcgggct cctgggcgcc gcacctgctg agcgaggtga cagccagccc ggcgcccacc    420

tgggacgcgc ccccggacaa tgcctccggc tgtggggaac agatcaacta cggcagagtc    480

gagaaagttg tgatcggctc catcctgacg ctcatcacgc tgctgacgat cgcgggcaac    540

tgcctggtgg tgatctccgt gtgcttcgtc aagaagctcc gccagccctc caactacctg    600

atcgtgtccc tggcgctggc cgacctctcg gtggctgtgg cggtcatgcc cttcgtcagc    660

gtcaccgacc tcatcggggg caagtggatc tttggacact ttttctgtaa tgtcttcatc    720

gccatggacg tcatgtgctg cacggcctcg atcatgaccc tgtgcgtgat cagcattgac    780

aggtaccttg ggatcacaag gcccctcaca taccctgtga ggcagaatgg gaaatgcatg    840

gcgaagatga ttctctccgt ctggcttctc tccgcctcca tcaccttacc tccactcttt    900

ggatgggctc agaatgtaaa tgatgataag gtgtgcttga tcagccagga ctttggctat    960

acgatttact ctaccgcagt ggcattttat atccccatgt ccgtcatgct tttcatgtac   1020

taccagattt acaaggctgc caggaagagt gctgccaaac acaagtttcc tggcttccct   1080

cgagtggagc cagacagcgt catcgccctg aatggcatag tgaagctcca gaaggaggtg   1140

gaagagtgtg caaacctttc gagactcctc aagcatgaaa ggaaaaacat ctccatcttt   1200

aagcgagaac agaaagcagc caccaccctg gggatcatcg tcggggcctt taccgtgtgc   1260

tggctgccat ttttcctcct ctcgacagcc agacccttca tctgtggcac ttcctgcagc   1320

tgcatcccac tgtgggtgga gaggacattt ctgtggctag gctatgcaaa ctctctcatt   1380

aaccctttta tatatgcctt cttcaaccgg gacctgagga ccacctatcg cagcctgctc   1440

cagtgccagt accggaatat caaccggaag ctctcagctg caggcatgca tgaagccctg   1500

aagcttgctg agaggccaga gagacctgag tttgtgctga gggcctgcac aaggagggtg   1560

ctgttgagac cagaaaagag gccaccggta tctgtgtggg tgctacaatc tccagaccat   1620

cacaattggt tagcagacaa aatgctgact actgtagaaa aaaaggtcat gattcatgat   1680

tgaaagcaga acaatggaga tgaaataaac aaggcaaaat agaggtggaa acagaaggaa   1740

gtcatttgct gagtctgcag aatggaatgc agcttctgtc ctttcttggg atgtctaaaa   1800

catgacaaac agggtgatct gttgtacaca ctatcttatg agggagatgg tgacttctcc   1860

tttttttctg tggatcagtg ctattgtgtg ttctcagttt aagatagcag atcatctcag   1920

cagtaagcac accaacagaa ctgagttcca gaaaggaagc agtttctggt gctttgcata   1980

tgtccaaatc catgcaagtg ggagaaagtt ccagtgcaca cttcccatgc ttctgagtct   2040

aggcgttgtg gtgaatatgc aggaatcatt catgagacag aatgtatttt gttgtatgac   2100

agaaggcttt tccaagcaaa ctgcggtgag cgtagtgttg aatatgttgc atgtccatgt   2160

tagaaaacag aatccagtca tcagctaata caaatgattt cccagagcag tgtttgtttc   2220

aagcttctgt caaatagttt ggcttttctg cagggtctct gtgatttccc cacctatgta   2280

cttttctgtg ttaactcact tattatggta taactcagga acaggtctca ggatggagag   2340

aagcatacaa catgagcaaa gctttttctc gtgctctgaa gggtcttgag aggggagtgg   2400

gatgccttct gtgaggattt ttatcgcagt gaagctcaag tggtacccaa ctgcgttgta   2460

attaacatga ttattggcat gtttttgact ctcattttct acaaggctgc agtgggccca   2520

cccatgggct ggcccataac tgtatgttat gtggaagaag tgtgggaatg atgggttttc   2580

catgaaatgt gatgcttctg gagatggggc ataaacatgt tcattcttgt tgagctgcat   2640

tgtgttaaac caaattgtgt gaagcgaggt cacctggacc actcttggga aatgcttcag   2700

aacaccagtc tgttccttct agagaatttg tttttgtgtt ctatgtatct taaatcaaat   2760

gtgtgcctaa gcaattctgt cctctgattc ccacccctac ccaccaaaaa atggtagaca   2820

tgaaaggcag gtgaggaaac agaaaaggtc tctttgcaga tatatatttt ttaaatggca   2880

ctatgtagta attaagagct aaggagacag aaagacagta gatgagaata gaagagtacc   2940

tgtacctaca aggggaaaaa tgaatgcaat tctttatttg ataagagtga actgaaagag   3000

aatattattt tcctacaata aagcaagctg tcctctcaca ggataaagtg gaattctgac   3060

atggattatg gacttcttct aactcccatt gacattgctt cttaccagac atggggaaaa   3120

gctacctttc ctgaaagggg aggagggcac tgtcctttca gacaaagctt gtacaaattc   3180

ctgaaccgca aatttgctga agtgaccgta tatattatat tcataattta aatgattatt   3240

tatggtcaga tacatattgt taaacttgaa aatgttttat tacattacat caaataaagt   3300

ttatttgtag ctgaaataaa gcaacgtaag taacaatttt taattaaaaa aaaaaaaaaa   3360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                             3396


<210>  2563
<211>  479
<212>  PRT
<213>  Homosapiens

<400>  2563

Met Met Asp Val Asn Ser Ser Gly Arg Pro Asp Leu Tyr Gly His Leu 
1               5                   10                  15      


Arg Ser Phe Leu Leu Pro Glu Val Gly Arg Gly Leu Pro Asp Leu Ser 
            20                  25                  30          


Pro Asp Gly Gly Ala Asp Pro Val Ala Gly Ser Trp Ala Pro His Leu 
        35                  40                  45              


Leu Ser Glu Val Thr Ala Ser Pro Ala Pro Thr Trp Asp Ala Pro Pro 
    50                  55                  60                  


Asp Asn Ala Ser Gly Cys Gly Glu Gln Ile Asn Tyr Gly Arg Val Glu 
65                  70                  75                  80  


Lys Val Val Ile Gly Ser Ile Leu Thr Leu Ile Thr Leu Leu Thr Ile 
                85                  90                  95      


Ala Gly Asn Cys Leu Val Val Ile Ser Val Cys Phe Val Lys Lys Leu 
            100                 105                 110         


Arg Gln Pro Ser Asn Tyr Leu Ile Val Ser Leu Ala Leu Ala Asp Leu 
        115                 120                 125             


Ser Val Ala Val Ala Val Met Pro Phe Val Ser Val Thr Asp Leu Ile 
    130                 135                 140                 


Gly Gly Lys Trp Ile Phe Gly His Phe Phe Cys Asn Val Phe Ile Ala 
145                 150                 155                 160 


Met Asp Val Met Cys Cys Thr Ala Ser Ile Met Thr Leu Cys Val Ile 
                165                 170                 175     


Ser Ile Asp Arg Tyr Leu Gly Ile Thr Arg Pro Leu Thr Tyr Pro Val 
            180                 185                 190         


Arg Gln Asn Gly Lys Cys Met Ala Lys Met Ile Leu Ser Val Trp Leu 
        195                 200                 205             


Leu Ser Ala Ser Ile Thr Leu Pro Pro Leu Phe Gly Trp Ala Gln Asn 
    210                 215                 220                 


Val Asn Asp Asp Lys Val Cys Leu Ile Ser Gln Asp Phe Gly Tyr Thr 
225                 230                 235                 240 


Ile Tyr Ser Thr Ala Val Ala Phe Tyr Ile Pro Met Ser Val Met Leu 
                245                 250                 255     


Phe Met Tyr Tyr Gln Ile Tyr Lys Ala Ala Arg Lys Ser Ala Ala Lys 
            260                 265                 270         


His Lys Phe Pro Gly Phe Pro Arg Val Glu Pro Asp Ser Val Ile Ala 
        275                 280                 285             


Leu Asn Gly Ile Val Lys Leu Gln Lys Glu Val Glu Glu Cys Ala Asn 
    290                 295                 300                 


Leu Ser Arg Leu Leu Lys His Glu Arg Lys Asn Ile Ser Ile Phe Lys 
305                 310                 315                 320 


Arg Glu Gln Lys Ala Ala Thr Thr Leu Gly Ile Ile Val Gly Ala Phe 
                325                 330                 335     


Thr Val Cys Trp Leu Pro Phe Phe Leu Leu Ser Thr Ala Arg Pro Phe 
            340                 345                 350         


Ile Cys Gly Thr Ser Cys Ser Cys Ile Pro Leu Trp Val Glu Arg Thr 
        355                 360                 365             


Phe Leu Trp Leu Gly Tyr Ala Asn Ser Leu Ile Asn Pro Phe Ile Tyr 
    370                 375                 380                 


Ala Phe Phe Asn Arg Asp Leu Arg Thr Thr Tyr Arg Ser Leu Leu Gln 
385                 390                 395                 400 


Cys Gln Tyr Arg Asn Ile Asn Arg Lys Leu Ser Ala Ala Gly Met His 
                405                 410                 415     


Glu Ala Leu Lys Leu Ala Glu Arg Pro Glu Arg Pro Glu Phe Val Leu 
            420                 425                 430         


Arg Ala Cys Thr Arg Arg Val Leu Leu Arg Pro Glu Lys Arg Pro Pro 
        435                 440                 445             


Val Ser Val Trp Val Leu Gln Ser Pro Asp His His Asn Trp Leu Ala 
    450                 455                 460                 


Asp Lys Met Leu Thr Thr Val Glu Lys Lys Val Met Ile His Asp 
465                 470                 475                 


<210>  2564
<211>  3303
<212>  DNA
<213>  Homosapiens

<400>  2564
gtcgggggcc gaagcgcctc ccgcagggag tccccgtgag gccgcgctgc cgcgttaccc     60

gcagcggccg ggggtccggg gagtgcgggg ctccgagaca gagccaggcg ccccccagcg    120

gtcggcgcgg gccccatggc tgggccgggc ggagcggaac cggtgaggtg aagccccggg    180

gccggcagcc ggaggcgcgt ggccggggcg ccggctccat gggcagcggc acacggcggc    240

gcgatgatgg acgttaacag cagcggccgc ccggacctct acgggcacct ccgctctttc    300

cttctgccag aagtggggcg cgggctgccc gacttgagcc ccgacggtgg cgccgacccg    360

gtcgcgggct cctgggcgcc gcacctgctg agcgaggtga cagccagccc ggcgcccacc    420

tgggacgcgc ccccggacaa tgcctccggc tgtggggaac agatcaacta cggcagagtc    480

gagaaagttg tgatcggctc catcctgacg ctcatcacgc tgctgacgat cgcgggcaac    540

tgcctggtgg tgatctccgt gtgcttcgtc aagaagctcc gccagccctc caactacctg    600

atcgtgtccc tggcgctggc cgacctctcg gtggctgtgg cggtcatgcc cttcgtcagc    660

gtcaccgacc tcatcggggg caagtggatc tttggacact ttttctgtaa tgtcttcatc    720

gccatggacg tcatgtgctg cacggcctcg atcatgaccc tgtgcgtgat cagcattgac    780

aggtaccttg ggatcacaag gcccctcaca taccctgtga ggcagaatgg gaaatgcatg    840

gcgaagatga ttctctccgt ctggcttctc tccgcctcca tcaccttacc tccactcttt    900

ggatgggctc agaatgtaaa tgatgataag gtgtgcttga tcagccagga ctttggctat    960

acgatttact ctaccgcagt ggcattttat atccccatgt ccgtcatgct tttcatgtac   1020

taccagattt acaaggctgc caggaagagt gctgccaaac acaagtttcc tggcttccct   1080

cgagtggagc cagacagcgt catcgccctg aatggcatag tgaagctcca gaaggaggtg   1140

gaagagtgtg caaacctttc gagactcctc aagcatgaaa ggaaaaacat ctccatcttt   1200

aagcgagaac agaaagcagc caccaccctg gggatcatcg tcggggcctt taccgtgtgc   1260

tggctgccat ttttcctcct ctcgacagcc agacccttca tctgtggcac ttcctgcagc   1320

tgcatcccac tgtgggtgga gaggacattt ctgtggctag gctatgcaaa ctctctcatt   1380

aaccctttta tatatgcctt cttcaaccgg gacctgagga ccacctatcg cagcctgctc   1440

cagtgccagt accggaatat caaccggaag ctctcagctg caggcatgca tgaagccctg   1500

aagcttgctg agaggccaga gagacctgag tttgtgctgt aagacaaaat gctgactact   1560

gtagaaaaaa aggtcatgat tcatgattga aagcagaaca atggagatga aataaacaag   1620

gcaaaataga ggtggaaaca gaaggaagtc atttgctgag tctgcagaat ggaatgcagc   1680

ttctgtcctt tcttgggatg tctaaaacat gacaaacagg gtgatctgtt gtacacacta   1740

tcttatgagg gagatggtga cttctccttt ttttctgtgg atcagtgcta ttgtgtgttc   1800

tcagtttaag atagcagatc atctcagcag taagcacacc aacagaactg agttccagaa   1860

aggaagcagt ttctggtgct ttgcatatgt ccaaatccat gcaagtggga gaaagttcca   1920

gtgcacactt cccatgcttc tgagtctagg cgttgtggtg aatatgcagg aatcattcat   1980

gagacagaat gtattttgtt gtatgacaga aggcttttcc aagcaaactg cggtgagcgt   2040

agtgttgaat atgttgcatg tccatgttag aaaacagaat ccagtcatca gctaatacaa   2100

atgatttccc agagcagtgt ttgtttcaag cttctgtcaa atagtttggc ttttctgcag   2160

ggtctctgtg atttccccac ctatgtactt ttctgtgtta actcacttat tatggtataa   2220

ctcaggaaca ggtctcagga tggagagaag catacaacat gagcaaagct ttttctcgtg   2280

ctctgaaggg tcttgagagg ggagtgggat gccttctgtg aggattttta tcgcagtgaa   2340

gctcaagtgg tacccaactg cgttgtaatt aacatgatta ttggcatgtt tttgactctc   2400

attttctaca aggctgcagt gggcccaccc atgggctggc ccataactgt atgttatgtg   2460

gaagaagtgt gggaatgatg ggttttccat gaaatgtgat gcttctggag atggggcata   2520

aacatgttca ttcttgttga gctgcattgt gttaaaccaa attgtgtgaa gcgaggtcac   2580

ctggaccact cttgggaaat gcttcagaac accagtctgt tccttctaga gaatttgttt   2640

ttgtgttcta tgtatcttaa atcaaatgtg tgcctaagca attctgtcct ctgattccca   2700

cccctaccca ccaaaaaatg gtagacatga aaggcaggtg aggaaacaga aaaggtctct   2760

ttgcagatat atatttttta aatggcacta tgtagtaatt aagagctaag gagacagaaa   2820

gacagtagat gagaatagaa gagtacctgt acctacaagg ggaaaaatga atgcaattct   2880

ttatttgata agagtgaact gaaagagaat attattttcc tacaataaag caagctgtcc   2940

tctcacagga taaagtggaa ttctgacatg gattatggac ttcttctaac tcccattgac   3000

attgcttctt accagacatg gggaaaagct acctttcctg aaaggggagg agggcactgt   3060

cctttcagac aaagcttgta caaattcctg aaccgcaaat ttgctgaagt gaccgtatat   3120

attatattca taatttaaat gattatttat ggtcagatac atattgttaa acttgaaaat   3180

gttttattac attacatcaa ataaagttta tttgtagctg aaataaagca acgtaagtaa   3240

caatttttaa ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3300

aaa                                                                 3303


<210>  2565
<211>  432
<212>  PRT
<213>  Homosapiens

<400>  2565

Met Met Asp Val Asn Ser Ser Gly Arg Pro Asp Leu Tyr Gly His Leu 
1               5                   10                  15      


Arg Ser Phe Leu Leu Pro Glu Val Gly Arg Gly Leu Pro Asp Leu Ser 
            20                  25                  30          


Pro Asp Gly Gly Ala Asp Pro Val Ala Gly Ser Trp Ala Pro His Leu 
        35                  40                  45              


Leu Ser Glu Val Thr Ala Ser Pro Ala Pro Thr Trp Asp Ala Pro Pro 
    50                  55                  60                  


Asp Asn Ala Ser Gly Cys Gly Glu Gln Ile Asn Tyr Gly Arg Val Glu 
65                  70                  75                  80  


Lys Val Val Ile Gly Ser Ile Leu Thr Leu Ile Thr Leu Leu Thr Ile 
                85                  90                  95      


Ala Gly Asn Cys Leu Val Val Ile Ser Val Cys Phe Val Lys Lys Leu 
            100                 105                 110         


Arg Gln Pro Ser Asn Tyr Leu Ile Val Ser Leu Ala Leu Ala Asp Leu 
        115                 120                 125             


Ser Val Ala Val Ala Val Met Pro Phe Val Ser Val Thr Asp Leu Ile 
    130                 135                 140                 


Gly Gly Lys Trp Ile Phe Gly His Phe Phe Cys Asn Val Phe Ile Ala 
145                 150                 155                 160 


Met Asp Val Met Cys Cys Thr Ala Ser Ile Met Thr Leu Cys Val Ile 
                165                 170                 175     


Ser Ile Asp Arg Tyr Leu Gly Ile Thr Arg Pro Leu Thr Tyr Pro Val 
            180                 185                 190         


Arg Gln Asn Gly Lys Cys Met Ala Lys Met Ile Leu Ser Val Trp Leu 
        195                 200                 205             


Leu Ser Ala Ser Ile Thr Leu Pro Pro Leu Phe Gly Trp Ala Gln Asn 
    210                 215                 220                 


Val Asn Asp Asp Lys Val Cys Leu Ile Ser Gln Asp Phe Gly Tyr Thr 
225                 230                 235                 240 


Ile Tyr Ser Thr Ala Val Ala Phe Tyr Ile Pro Met Ser Val Met Leu 
                245                 250                 255     


Phe Met Tyr Tyr Gln Ile Tyr Lys Ala Ala Arg Lys Ser Ala Ala Lys 
            260                 265                 270         


His Lys Phe Pro Gly Phe Pro Arg Val Glu Pro Asp Ser Val Ile Ala 
        275                 280                 285             


Leu Asn Gly Ile Val Lys Leu Gln Lys Glu Val Glu Glu Cys Ala Asn 
    290                 295                 300                 


Leu Ser Arg Leu Leu Lys His Glu Arg Lys Asn Ile Ser Ile Phe Lys 
305                 310                 315                 320 


Arg Glu Gln Lys Ala Ala Thr Thr Leu Gly Ile Ile Val Gly Ala Phe 
                325                 330                 335     


Thr Val Cys Trp Leu Pro Phe Phe Leu Leu Ser Thr Ala Arg Pro Phe 
            340                 345                 350         


Ile Cys Gly Thr Ser Cys Ser Cys Ile Pro Leu Trp Val Glu Arg Thr 
        355                 360                 365             


Phe Leu Trp Leu Gly Tyr Ala Asn Ser Leu Ile Asn Pro Phe Ile Tyr 
    370                 375                 380                 


Ala Phe Phe Asn Arg Asp Leu Arg Thr Thr Tyr Arg Ser Leu Leu Gln 
385                 390                 395                 400 


Cys Gln Tyr Arg Asn Ile Asn Arg Lys Leu Ser Ala Ala Gly Met His 
                405                 410                 415     


Glu Ala Leu Lys Leu Ala Glu Arg Pro Glu Arg Pro Glu Phe Val Leu 
            420                 425                 430         


<210>  2566
<211>  2643
<212>  DNA
<213>  Homosapiens

<400>  2566
acacacacaa acgccttctt cccggagtat tgaatagttg ggaattggaa cccctccagg     60

gggaaccaaa cattgtcgtt cagaagaaga caaagagaga ttgaaatgaa gctgttgatt    120

tcaacacaca aattctggtg gtagatgaaa gcaaagcaag taagtttctc cgaatcccta    180

gtcaactgga ggtagagacg gactgcgcag gttaactaca gctcccagca tgcctgaggg    240

gcgggctcag cggctgcgca gactggcgcg cgcggacggt catgggactt cagcatggcg    300

gtgtttgcag atttggacct gcgagcgggt tctgacctga aggctctgcg cggacttgtg    360

gagacagccg ctcaccttgg ctattcagtt gttgctatca atcatatcgt tgactttaag    420

gaaaagaaac aggaaattga aaaaccagta gctgtttctg aactcttcac aactttgcca    480

attgtacagg gaaaatcaag accaattaaa attttaacta gattaacaat tattgtctcg    540

gatccatctc actgcaatgt tttgagagca acttcttcaa gggcccggct ctatgatgtt    600

gttgcagttt ttccaaagac agaaaagctt tttcatattg cttgcacaca tttagatgtg    660

gatttagtct gcataactgt aacagagaaa ctaccatttt acttcaaaag acctcctatt    720

aatgtggcga ttgaccgagg cctggctttt gaacttgtct atagccctgc tatcaaagac    780

tccacaatga gaaggtatac aatttccagt gccctcaatt tgatgcaaat ctgcaaagga    840

aagaatgtaa ttatatctag tgctgcagaa aggcctttag aaataagagg gccatatgac    900

gtggcaaatc taggcttgct gtttgggctc tctgaaagtg acgccaaggc tgcggtgtcc    960

accaactgcc gagcagcgct tctccatgga gaaactagaa aaactgcttt tggaattatc   1020

tctacagtga agaaacctcg gccatcagaa ggagatgaag attgtcttcc agcttccaag   1080

aaagccaagt gtgagggctg aaaagaatgc cccagtctct gtcagcactc ccttcttccc   1140

ttttatagtt catcagccac aacaaaaata aaacctttgt gtgatttact gttttcattt   1200

ggagctagaa atcaatagtc tataaaaaca gttttacttg caatccatta aaacaacaaa   1260

cgaaacctag tgaagcatct ttttaaaagg ctgccagctt aatgaattta gatgtacttt   1320

aagagagaaa gactggttat ttctcctttg tgtaagtgat aaacaacagc aaatatactt   1380

gaataaaatg tttcaggtat ttttgtttca ttttgttttt gagatagggt ctttgttgct   1440

caggctggag tacagtggca taatcacagc tcactgcaac ctcaatcctg ggctcaagtg   1500

atcctcccgc ttcagcctct caagcagcgg gaactacagg tgtgcactac cacacctggc   1560

tatttttttt tttttttttt ttttcccttg tagagacatg gtctcactat gttgctgagg   1620

ctggtctcaa actcctagga tcaagccatc ctcccgcttt ggcctcctaa agtgctggga   1680

ttacatgagc caccacatgc agccagatgt ttgaatattt taagagcttc tttcgaaagt   1740

ttcttgttca tactcaaata gtagttattt tgaagatatt caaacttata ttgaagaagt   1800

gactttagtt cctcttgttt taagcttctt tcatgtattc aaatcagcat ttttttctaa   1860

gaaattgcta tagaatttgt ggaaggagag aggatacaca tgtaaaatta catctggtct   1920

cttccttcac tgcttcatgc ctacgtaagg tctttgaaat aggattcctt acttttagtt   1980

agaaacccct aaaacgctaa tattgatttt cctgatagct gtattaaaaa tagcaaagca   2040

tcggactgaa ccaactttgg aaataattta tttttataat gggatcatgt taagtagaag   2100

tagcttttta tgcaaataca tgcatttatg caatattaat gtaagggctc taaaacaatg   2160

gagtagagcc agaggtataa ctgaataaga aattttttta agcaagagaa agacaactgt   2220

tctgcgggtt ggagaaaata caattttttt tttttttttt tttgagacag tctcgctctg   2280

tcccccaggc tggagtgcag tggctcgatc tctgctcact gcaagctccg cctcctgggt   2340

tcatgccatt ctcctgcctc agcctcctga gtagctggga ctacaggcgc tcgccatgta   2400

tttagcagag acggggtttc accgtgttag ccaggatggt ctcaatctcc tgacctcata   2460

ttccacccgc ctcggcctcc caaagtgctg ggattacagg cgttagccac tgcgcccggc   2520

ccgagaaaat acagttttaa aaagagaaag ctttataacc tcaccaatga atacaaatgt   2580

ttaaataaaa tattgattaa aaaaacatta aaagcgaaaa aaaaaaaaaa aaaaaaaaaa   2640

aaa                                                                 2643


<210>  2567
<211>  268
<212>  PRT
<213>  Homosapiens

<400>  2567

Met Ala Val Phe Ala Asp Leu Asp Leu Arg Ala Gly Ser Asp Leu Lys 
1               5                   10                  15      


Ala Leu Arg Gly Leu Val Glu Thr Ala Ala His Leu Gly Tyr Ser Val 
            20                  25                  30          


Val Ala Ile Asn His Ile Val Asp Phe Lys Glu Lys Lys Gln Glu Ile 
        35                  40                  45              


Glu Lys Pro Val Ala Val Ser Glu Leu Phe Thr Thr Leu Pro Ile Val 
    50                  55                  60                  


Gln Gly Lys Ser Arg Pro Ile Lys Ile Leu Thr Arg Leu Thr Ile Ile 
65                  70                  75                  80  


Val Ser Asp Pro Ser His Cys Asn Val Leu Arg Ala Thr Ser Ser Arg 
                85                  90                  95      


Ala Arg Leu Tyr Asp Val Val Ala Val Phe Pro Lys Thr Glu Lys Leu 
            100                 105                 110         


Phe His Ile Ala Cys Thr His Leu Asp Val Asp Leu Val Cys Ile Thr 
        115                 120                 125             


Val Thr Glu Lys Leu Pro Phe Tyr Phe Lys Arg Pro Pro Ile Asn Val 
    130                 135                 140                 


Ala Ile Asp Arg Gly Leu Ala Phe Glu Leu Val Tyr Ser Pro Ala Ile 
145                 150                 155                 160 


Lys Asp Ser Thr Met Arg Arg Tyr Thr Ile Ser Ser Ala Leu Asn Leu 
                165                 170                 175     


Met Gln Ile Cys Lys Gly Lys Asn Val Ile Ile Ser Ser Ala Ala Glu 
            180                 185                 190         


Arg Pro Leu Glu Ile Arg Gly Pro Tyr Asp Val Ala Asn Leu Gly Leu 
        195                 200                 205             


Leu Phe Gly Leu Ser Glu Ser Asp Ala Lys Ala Ala Val Ser Thr Asn 
    210                 215                 220                 


Cys Arg Ala Ala Leu Leu His Gly Glu Thr Arg Lys Thr Ala Phe Gly 
225                 230                 235                 240 


Ile Ile Ser Thr Val Lys Lys Pro Arg Pro Ser Glu Gly Asp Glu Asp 
                245                 250                 255     


Cys Leu Pro Ala Ser Lys Lys Ala Lys Cys Glu Gly 
            260                 265             


<210>  2568
<211>  5840
<212>  DNA
<213>  Homosapiens

<400>  2568
gtctccacta gaggctgcac agcccgcccg gaccaacgcc tccgcgcctg ccgccgtctg     60

gccggcgccc tcccgtttcc ttcctccagg gggaaaaaat gtctttcggg ccgctttcca    120

ggaagcagca ggatgcgccg ctccactgtc ggtagcaaca agctgcgcaa accatgcagg    180

atgatttact gatggacaaa agcaaaaccc agccccagcc ccagcagcag cagcggcagc    240

agcagcagcc ccaacctgag tccagcgtat ccgaagcccc gtccacgccc ctctcctcag    300

agacccccaa gccggaggaa aacagcgcag tgccggccct cagcccagcc gctgcccccc    360

cggcccccaa cggcccggac aagatgcaga tggaatcacc gctcctgcca ggcttgagtt    420

tccatcagcc tcctcagcag ccgccgccgc ctcaggagcc cgcggcaccg ggcgcgtcgc    480

tgtcgccgtc cttcggcagc acctggtcca cgggcaccac caacgcggta gaggacagct    540

tcttccaggg gatcacccca gtcaacggga ccatgctctt ccagaacttc ccgcaccatg    600

tcaacccagt cttcggaggc actttctccc cgcagatcgg cctggcgcag acccagcacc    660

accagcagcc gccgccgcct gcgcccgcgc cgcagccggc acagccagcg cagccaccac    720

aggcgcagcc cccgcagcag cgccgctcac ccgccagccc cagccaggcg ccctacgcgc    780

agaggagcgc cgccgcggcg tacggccacc agcccatcat gaccagcaag ccgtcctcgt    840

cttcggcggt tgcagccgct gctgccgcag ccgccgcctc gtcggcctcg tccagctgga    900

acacgcacca aagcgtgaat gcagcctgga gcgcaccgtc caacccctgg ggcggcctgc    960

aggcgggccg ggaccctcgc cgggcggtcg gtgtgggcgt gggtgtgggt gtcggggtgc   1020

cttccccgct caaccccatc tcgccgctca aaaagccctt ctccagcaac gtgatcgcgc   1080

cgcccaagtt ccctcgcgcg gcccctctca cttccaagtc ctggatggag gataacgctt   1140

tccggaccga taatggtaac aatctgttgc catttcagga ccggagtagg ccctatgata   1200

cttttaactt gcactcgttg gagaactcct taatggatat gataaggact gatcatgaac   1260

ctctgaaagg taaacactac cctcccagtg gcccaccaat gagtttcgct gatataatgt   1320

ggaggaatca ttttgcagga cgcatgggga taaatttcca tcatccagga acagataata   1380

ttatggcact taacaatgcc ttcctggatg atagccatgg tgatcaagcc ttgtcatctg   1440

gcttaagttc tcccactcgc tgtcaaaatg gggaacgagt agaacgctac tctagaaagg   1500

tgtttgttgg aggacttcct cctgatattg atgaagatga gatcactgcc agctttcgca   1560

ggtttggacc tctcgtagta gactggcctc acaaagctga aagcaagtct tattttcctc   1620

ctaaaggcta tgcctttctg ctgttccaag aggaaagctc agtacaagct ttgatagatg   1680

cctgcctaga agaagatggg aaactctacc tgtgtgtgtc aagccccacc atcaaggaca   1740

agccagtgca aattcgacca tggaacctaa gtgacagtga ctttgtaatg gatggttctc   1800

agcctttgga ccccagaaaa actatctttg ttgggggagt tccacgaccc cttcgagctg   1860

ttgaactggc aatgatcatg gaccgtttgt acggtggtgt ctgctatgct ggcattgata   1920

cggacccaga gctgaagtac cccaaaggtg ctggccgcgt ggcattctcc aatcagcaga   1980

gttacattgc agccatcagc gctcgttttg tgcagcttca gcacaatgac attgacaaac   2040

gggttgaagt aaagccatat gtgctggatg atcagatgtg tgatgagtgc cagggcacac   2100

gctgtggtgg gaagtttgcc ccgttcttct gtgccaacgt cacctgtctg cagtattact   2160

gtgaatactg ctgggcgagc atacattccc gagccgggcg ggagttccac aaaccgctgg   2220

tgaaggaggg aggcgaccgc cctcgtcacg tcccgttccg ctggagctga gccacgggcc   2280

gacccagcca caagtactgg agtagataac aaggagggaa aagagagggc actgcctcag   2340

ggcttacagt gttctggaaa tctgtgcatt cgttctcgat ttttaaagaa gaattgggtc   2400

tttttattat tattattatt atttacagtc atattactga actcagtgtc cagtataatg   2460

cagaattgca gagtgtagaa tggtactgat ttgcactttg attcacacct ttgtctgctt   2520

ggtaccttaa ttttttatac ctgatttgtc actcgtgaca gtatgtagac tgccattctc   2580

atcagcggcc gtcaggctac tgtctgtgat tcttttgttt gttgttgtgg tgttgttctg   2640

attgttttga actggagcat gcacttattt tcagaaactt agagagttgc ccctaggaca   2700

agacttacca aaggtaatac tcgtgagtag gtggcagatg tagcaaaaac ttcacaacaa   2760

ttcagcaatc attagctcgg gtcacttaga gtaaggataa cccttcatga aaataagcct   2820

ttagttgctc tctattttga cttgtaagga tacctcataa gctggatctt ttatttttcc   2880

ttcatgtttg atttttgttt tgccgaggat tttggttaga tcttttagta ttatgtaaat   2940

ttatgctgca atagcttttg ctgctattaa aatggtatta ttaataccat aatactctat   3000

tcaggctagg atatcaatta aacacaaaaa cccaacaaca cacttttgtg attttaggga   3060

tagagtcagc tgccgaacgg agatcagaat agacttcaga aagcttcggt ggaaggtcac   3120

tatttctgac tgcatgttta cttaatcagg ttgctgcatg caataaattt tatatccaat   3180

gtctagtata aaacgttccc acaatgcaca aattaagaat ctatataagc tataaaaata   3240

ctcatttttt aaaaaaagtt tttttcattc aaagaattgg taattgaccg gaggaaggca   3300

tgcctcaata aatggaatgc tctgaatggg aagagcccat aacagaatga cctatattac   3360

aaccgatata aaacctaggt gtaggatatt cttcaagcaa atttgtggat ggtagatgaa   3420

gtactttgcg gtgctctgtt atatattgtg aaatttattt tatatagtaa agtgattatg   3480

tctaactgtg atcaaactta actgtttaaa gcctctgtca gacattaatg aacttgacag   3540

ttcataactg atatattata aactaacaca tgagctctta gttacaatct cttagtgctt   3600

gcaccatttt acatagcttc agaccttgtc cagaaaacca aagagctcat cttagcttac   3660

aaacactaag aatatataca ggatatagag ataagttgtc agattgacaa actaggcaca   3720

tttttaagaa agttgtgtaa tggtgatgct aaagaaatgt ctgtacaaaa taagatggcc   3780

tgggcagagt tggttgtctg agtgagaaac taactactta attccctgga tttatcctgt   3840

taagcttgag tagaatgaag gcctgctagc actagcgtgg tctagaatga aggcctgcta   3900

gcactagcgt ggacattttt ctagcattca cccttgggct gcagatagta atatataaac   3960

acacacaatg attgcaagac tatgtaaatc tttttttaat cttcttccta tgttttggaa   4020

ttctggggac aatctgactg gatatgacac tgcagaatag atttaagtcg ctgtgttttc   4080

tgtgctgtga tgtccttgta ctgtcttaag ttagtgttgc ttgtttttgt tttgttctcc   4140

catgtttagt tgcaattact ggctctcaag ctatagtttg ttttcaaaaa ggaaaaacaa   4200

aatagttttt tactggatta aaaatgctta ttttagaatc ctcccctttt tgaggctttt   4260

tggtaataat tgcttttttc cagcccaggt gtggttttgt ttgttttttt ctatgtttgt   4320

gggttttttt tcatctgtac aagaaatttt gttatgcact actacttttt gtattctaga   4380

cagttttcaa aagttggcag attttttttt ttgtttttaa ggaaaaaggc atgctttctg   4440

actgacatga tcttttgcaa tacctcaatt ttgaaatata ggaaagaaaa tgatattttc   4500

taagtaagtt tattcagaaa aatatatatt aatttaattc tgcaagaaaa tgatttaaca   4560

gatgggtaac tttatttttt tcatgcttat ttgtgttttt tgaaaatgaa gaagttagag   4620

ctttataact ataatattaa agatcatatc taacctacag aaatctacct aattatgtga   4680

aagaagcaaa actttttgaa gaagcacccc tctttcatgt attaaaataa cactgagatt   4740

tttttaaaag ctggaagatt gtacagcata aagctaaagt gaaggcaaaa aacattgtcc   4800

tgaagaatag gttacaaaaa ataaactcca tttggtgctg aaagttgtga atagatggtg   4860

gaaactactt tcccttaatt tgtatatttc taatcaagtg ttgattgtgc gcgactgacc   4920

aggattgtga aagagttctt ctgtttgtat ttttttaaag agaacttttt tagtttatta   4980

aattataaca tgttcccttt tgttttgtaa ataaatgtgc ccccaagttg ttaatgttat   5040

attaaaagag agggtccttc aaaaaaatta ttttttaaaa cacagaggtg ttctgacctg   5100

caacttgact gggaagcccc tgggtaacac aggtcctgct gtggcctttc cttggtgtga   5160

cacttgaact agtcgatttt ttgaaggcta taacctaacc tcgactattt gttgttatgt   5220

gcaatactgt ttgtactgtt tgtataaaaa atagaaaaaa aaaagaaaag aaaaaaggca   5280

taaatcttta ttgcagattt attttcattg caaactttag acattgtgat tcactgaaat   5340

catttttcta ctgtcaaata tgtacctttt cttcatgctg gtattttttc aatagtaatg   5400

tagcctttgt actgagacaa attttcattg ttatttttag aaagattttt tgctaagaaa   5460

aaaattaaac atatttacat atttttcatt ttatttcgta ttttctttaa ggagtgcttt   5520

ctcaatcatt aatagagttg tttctgggag ggactttcat atctggtcaa tgtcataata   5580

ttattttgta tttttattgg aataaattaa ttttatgatg ctaattcttt aaaagtttat   5640

ttttttcatt ttcagttatt tttgaagcta aaacctttgt aatattgtta ctaaagtgtc   5700

tagttttttg aaatgcaaag ctttatgtat taacttgctg atgtggttta caatagtgtg   5760

acaacgatga aaatgcttgg ttatgtaaag tgattggaaa tgtaatggat aattgggtaa   5820

taaaatgaca gaatgagcag                                               5840


<210>  2569
<211>  698
<212>  PRT
<213>  Homosapiens

<400>  2569

Met Gln Asp Asp Leu Leu Met Asp Lys Ser Lys Thr Gln Pro Gln Pro 
1               5                   10                  15      


Gln Gln Gln Gln Arg Gln Gln Gln Gln Pro Gln Pro Glu Ser Ser Val 
            20                  25                  30          


Ser Glu Ala Pro Ser Thr Pro Leu Ser Ser Glu Thr Pro Lys Pro Glu 
        35                  40                  45              


Glu Asn Ser Ala Val Pro Ala Leu Ser Pro Ala Ala Ala Pro Pro Ala 
    50                  55                  60                  


Pro Asn Gly Pro Asp Lys Met Gln Met Glu Ser Pro Leu Leu Pro Gly 
65                  70                  75                  80  


Leu Ser Phe His Gln Pro Pro Gln Gln Pro Pro Pro Pro Gln Glu Pro 
                85                  90                  95      


Ala Ala Pro Gly Ala Ser Leu Ser Pro Ser Phe Gly Ser Thr Trp Ser 
            100                 105                 110         


Thr Gly Thr Thr Asn Ala Val Glu Asp Ser Phe Phe Gln Gly Ile Thr 
        115                 120                 125             


Pro Val Asn Gly Thr Met Leu Phe Gln Asn Phe Pro His His Val Asn 
    130                 135                 140                 


Pro Val Phe Gly Gly Thr Phe Ser Pro Gln Ile Gly Leu Ala Gln Thr 
145                 150                 155                 160 


Gln His His Gln Gln Pro Pro Pro Pro Ala Pro Ala Pro Gln Pro Ala 
                165                 170                 175     


Gln Pro Ala Gln Pro Pro Gln Ala Gln Pro Pro Gln Gln Arg Arg Ser 
            180                 185                 190         


Pro Ala Ser Pro Ser Gln Ala Pro Tyr Ala Gln Arg Ser Ala Ala Ala 
        195                 200                 205             


Ala Tyr Gly His Gln Pro Ile Met Thr Ser Lys Pro Ser Ser Ser Ser 
    210                 215                 220                 


Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Ala Ser Ser 
225                 230                 235                 240 


Ser Trp Asn Thr His Gln Ser Val Asn Ala Ala Trp Ser Ala Pro Ser 
                245                 250                 255     


Asn Pro Trp Gly Gly Leu Gln Ala Gly Arg Asp Pro Arg Arg Ala Val 
            260                 265                 270         


Gly Val Gly Val Gly Val Gly Val Gly Val Pro Ser Pro Leu Asn Pro 
        275                 280                 285             


Ile Ser Pro Leu Lys Lys Pro Phe Ser Ser Asn Val Ile Ala Pro Pro 
    290                 295                 300                 


Lys Phe Pro Arg Ala Ala Pro Leu Thr Ser Lys Ser Trp Met Glu Asp 
305                 310                 315                 320 


Asn Ala Phe Arg Thr Asp Asn Gly Asn Asn Leu Leu Pro Phe Gln Asp 
                325                 330                 335     


Arg Ser Arg Pro Tyr Asp Thr Phe Asn Leu His Ser Leu Glu Asn Ser 
            340                 345                 350         


Leu Met Asp Met Ile Arg Thr Asp His Glu Pro Leu Lys Gly Lys His 
        355                 360                 365             


Tyr Pro Pro Ser Gly Pro Pro Met Ser Phe Ala Asp Ile Met Trp Arg 
    370                 375                 380                 


Asn His Phe Ala Gly Arg Met Gly Ile Asn Phe His His Pro Gly Thr 
385                 390                 395                 400 


Asp Asn Ile Met Ala Leu Asn Asn Ala Phe Leu Asp Asp Ser His Gly 
                405                 410                 415     


Asp Gln Ala Leu Ser Ser Gly Leu Ser Ser Pro Thr Arg Cys Gln Asn 
            420                 425                 430         


Gly Glu Arg Val Glu Arg Tyr Ser Arg Lys Val Phe Val Gly Gly Leu 
        435                 440                 445             


Pro Pro Asp Ile Asp Glu Asp Glu Ile Thr Ala Ser Phe Arg Arg Phe 
    450                 455                 460                 


Gly Pro Leu Val Val Asp Trp Pro His Lys Ala Glu Ser Lys Ser Tyr 
465                 470                 475                 480 


Phe Pro Pro Lys Gly Tyr Ala Phe Leu Leu Phe Gln Glu Glu Ser Ser 
                485                 490                 495     


Val Gln Ala Leu Ile Asp Ala Cys Leu Glu Glu Asp Gly Lys Leu Tyr 
            500                 505                 510         


Leu Cys Val Ser Ser Pro Thr Ile Lys Asp Lys Pro Val Gln Ile Arg 
        515                 520                 525             


Pro Trp Asn Leu Ser Asp Ser Asp Phe Val Met Asp Gly Ser Gln Pro 
    530                 535                 540                 


Leu Asp Pro Arg Lys Thr Ile Phe Val Gly Gly Val Pro Arg Pro Leu 
545                 550                 555                 560 


Arg Ala Val Glu Leu Ala Met Ile Met Asp Arg Leu Tyr Gly Gly Val 
                565                 570                 575     


Cys Tyr Ala Gly Ile Asp Thr Asp Pro Glu Leu Lys Tyr Pro Lys Gly 
            580                 585                 590         


Ala Gly Arg Val Ala Phe Ser Asn Gln Gln Ser Tyr Ile Ala Ala Ile 
        595                 600                 605             


Ser Ala Arg Phe Val Gln Leu Gln His Asn Asp Ile Asp Lys Arg Val 
    610                 615                 620                 


Glu Val Lys Pro Tyr Val Leu Asp Asp Gln Met Cys Asp Glu Cys Gln 
625                 630                 635                 640 


Gly Thr Arg Cys Gly Gly Lys Phe Ala Pro Phe Phe Cys Ala Asn Val 
                645                 650                 655     


Thr Cys Leu Gln Tyr Tyr Cys Glu Tyr Cys Trp Ala Ser Ile His Ser 
            660                 665                 670         


Arg Ala Gly Arg Glu Phe His Lys Pro Leu Val Lys Glu Gly Gly Asp 
        675                 680                 685             


Arg Pro Arg His Val Pro Phe Arg Trp Ser 
    690                 695             


<210>  2570
<211>  3941
<212>  DNA
<213>  Homosapiens

<400>  2570
tcttacctca caaaggtagc tcctccgccg gcagcaactc ggcgcccgcg gtccatggac     60

cggaacctcg ggccgacgga cgggaacccg ggccgcgatc gccgcctccc cgcctcaggc    120

tcctcctcct cgctctccgc cgcctccgcc ggactcccgc aggccctgca ccgccgccgc    180

caggctagcg gagctgcccc gggaagctgg gtgacgggtt cgcggctgcc gccggactgc    240

ggcctactcc gccgcctctc agtgctattg tccctgggcc tggccttgag cgggtccact    300

ggggaaggcc gtgtgcgccg gctccgcgga agatgccgga ccaagcccta cagcagatgc    360

tggacagaag ttgctgggtt tgttttgcta ctgatgaaga tgatagaaca gctgaatggg    420

tgagaccatg caggtgcaga ggatctacaa aatgggttca ccaggcctgt ctacaacgct    480

gggtggatga aaagcaaaga ggaaacagta cagccagagt ggcatgtcct cagtgcaatg    540

ctgaatacct aatagttttt ccaaaattgg gtccagtggt ttacgtcttg gatcttgcag    600

atagactgat ctcaaaagcc tgtccatttg ctgcagcagg aataatggtc ggctctatct    660

attggacagc tgtgacttat ggagcagtga cagtgatgca ggttgtaggt cataaagaag    720

gtctggatgt tatggagaga gctgatcctt tattcctttt aattggactt cctactattc    780

ctgtcatgct gatattaggc aagatgattc gctgggagga ctatgtgctt agactgtggc    840

gcaaatactc gaataaacta caaattttaa atagtatatt tccagggata ggttgtcctg    900

ttcctcgaat tccagctgag gccaatcctt tagcagatca tgtctctgct actcgaatct    960

tgtgtggagc ccttgtcttt cctactattg ctacaatagt tggtaaattg atgttcagta   1020

gtgttaactc taatttacaa aggacaatct tgggtggaat tgcgtttgtt gccataaaag   1080

gagcatttaa agtttacttc aaacagcagc aatatttacg acaggcacac cgcaaaattc   1140

tgaattatcc agaacaagaa gaagcataaa actgacttct ggttgttctg cagttctctc   1200

atccttatga atctgttgtg ttgttttgat tccatcatta atgcacttgt ggagacttgt   1260

gataagctgc tgctcctata ttttttaaga aatataataa agcacttagg gcaggggaaa   1320

tcatctcggt aatcatggaa cctaaggatg tgatttgttt tcattgtttg tatgtactac   1380

ttttatggca gtcatatgaa ccattatctt agcatggtaa acctgggttt tgttcatatt   1440

ttctccagac agaaatgcaa agatcaaact gtgcaaatat taaaaaaatg cacatgctgt   1500

tttattcaaa tgcctctttt gtacatgttc atgtttagtg ttttctcaga atcagcaact   1560

caaggtacta tgaggatttt tctcactgac ataatttgat tacatactaa ataagaggat   1620

atgttaatat gaggaaatgt aaattaaatt agttataaat aaataaccaa aaatgtatgt   1680

aaacattcaa atgattatct gaacaaatga gattttgtgg tgttttcttt aacccatgtg   1740

atgtcctcca aaatgtgtag ggtaaaaatt cacagggctt ccagatcact ttttcaatat   1800

taaattttat ttacataatg ttgacatctc atacttcatg aagtaatttt gactcatgca   1860

gtcgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tatttgtgtg tttcagtgtt   1920

tcatcaggtc cttccatctc tgggagtttt ttcaacccat atttctagaa attacagctg   1980

ccagtttata gtagtttgag cagaggatga tttgcaaaaa taaaaataaa gttattttac   2040

tctcctcttg cattgattca gttattgaga tattcgttga tcacctccta tttcccaggc   2100

actgtgcaga gtgctgtagg acatagtggt gaacaagaca gacttggtcc aagctcttac   2160

agagttgaca gtctagtttc agcacataga aaaccagcag tgaataaacc aaggtgaggc   2220

cttgagctct ttgtttttat attaatgagg agaaaagtat gaaaacaaga agtcttaagt   2280

aaatattgag gtcattgttt ttggcttaag tttattatag aaaatcaaca ctaatgtttt   2340

tagattttaa ttgtcctatt gatgaggcta gcaccttaat cactgtttag ttttgtattc   2400

atttttaaaa gcaattattg aagccatttt caatagattg gccattttaa tgttcagcaa   2460

cctgaatggt tatttttgtt aattaaaatt aaatttttaa gagatatttt caaaacccta   2520

tttattttct tgttcacagt aatgcatgtc aataataaat gtttcccctt actgataagc   2580

ggccacttta ggagtgtagc aaatatagat tgagctatgt tagtttgcaa taatatatgt   2640

taactttagt aattaaagac tggtttctat agtatgaatg tcttaatttt gagttatatg   2700

atgtttattt gaatgactgt tgaacattca aatttgtatt atttggagat gaagatttga   2760

ctaacagtga gccttattaa gaacactact acagttctga aggggaaata taacatctat   2820

ggttatatat tttaaaaact tagattatag gctgtaatta taaaatatat tggcttttgt   2880

tttcaatgtg aaagatacat taaatggaca catatcttgc aaaattttgt tgtatagaac   2940

agtttttagg cagcctttac taaagttatg caaacacaca gttccccatt tactacatta   3000

atgcccttga cagggagtag ctgcttggtt ttataggtat tagggctcat gaaggccggg   3060

gaacaactct aatccttttg gggcaggagg gagggttttt ttagggttgc ggggagggaa   3120

ctgcaagtgc ctgaggacca gagtggcctc tagccccgaa ttgaacactt ttaaacctaa   3180

agagccttat tattattagc tcgagaaata ccacatgcca gtcttcccag gaaggtgacc   3240

tgcctgacca tgaagcaaca aaagagcata ggcagactta aagttggata gacctgggtt   3300

caaatcatag ttcagctttc aataactgta tgtatgattt tggctaaagg atttgacttt   3360

ctctcaactg cagttttctt aatctttgaa atgcaaataa tgtttatctc agaagactat   3420

ttctaggatt aactgagaga ttaaaggaac agcagcactt aggctcaaaa tcgcccctac   3480

aaagcagtag ttgtttctta attgctaagt aatctgtttg cactctagga aaagtaaatg   3540

gagaggtaaa agaaaggcat tggggacaaa tgaaagagat gatgtagatt tttcggatgg   3600

gtgggtatat tttattttcc agtttatttt catatttctt tactgtgtta tttctggaaa   3660

ctttaatgtt ttaaacctct tttataaaat tcaatgacga ctactagaat tcttttcaaa   3720

agttaactta tctccaaagt ggctgaaaat attgtttacc attacatgat tatgaaatga   3780

ctgtgaagaa tataaaatta aacttagtga cttaattagt cactgccttg ctaactttgc   3840

tgtaattttt ttaaacgtct tgtttttaat atagcaaact atctcaatac tggctggatt   3900

aggttaaata aagaattttt atgttcaaaa aaaaaaaaaa a                       3941


<210>  2571
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  2571

Met Pro Asp Gln Ala Leu Gln Gln Met Leu Asp Arg Ser Cys Trp Val 
1               5                   10                  15      


Cys Phe Ala Thr Asp Glu Asp Asp Arg Thr Ala Glu Trp Val Arg Pro 
            20                  25                  30          


Cys Arg Cys Arg Gly Ser Thr Lys Trp Val His Gln Ala Cys Leu Gln 
        35                  40                  45              


Arg Trp Val Asp Glu Lys Gln Arg Gly Asn Ser Thr Ala Arg Val Ala 
    50                  55                  60                  


Cys Pro Gln Cys Asn Ala Glu Tyr Leu Ile Val Phe Pro Lys Leu Gly 
65                  70                  75                  80  


Pro Val Val Tyr Val Leu Asp Leu Ala Asp Arg Leu Ile Ser Lys Ala 
                85                  90                  95      


Cys Pro Phe Ala Ala Ala Gly Ile Met Val Gly Ser Ile Tyr Trp Thr 
            100                 105                 110         


Ala Val Thr Tyr Gly Ala Val Thr Val Met Gln Val Val Gly His Lys 
        115                 120                 125             


Glu Gly Leu Asp Val Met Glu Arg Ala Asp Pro Leu Phe Leu Leu Ile 
    130                 135                 140                 


Gly Leu Pro Thr Ile Pro Val Met Leu Ile Leu Gly Lys Met Ile Arg 
145                 150                 155                 160 


Trp Glu Asp Tyr Val Leu Arg Leu Trp Arg Lys Tyr Ser Asn Lys Leu 
                165                 170                 175     


Gln Ile Leu Asn Ser Ile Phe Pro Gly Ile Gly Cys Pro Val Pro Arg 
            180                 185                 190         


Ile Pro Ala Glu Ala Asn Pro Leu Ala Asp His Val Ser Ala Thr Arg 
        195                 200                 205             


Ile Leu Cys Gly Ala Leu Val Phe Pro Thr Ile Ala Thr Ile Val Gly 
    210                 215                 220                 


Lys Leu Met Phe Ser Ser Val Asn Ser Asn Leu Gln Arg Thr Ile Leu 
225                 230                 235                 240 


Gly Gly Ile Ala Phe Val Ala Ile Lys Gly Ala Phe Lys Val Tyr Phe 
                245                 250                 255     


Lys Gln Gln Gln Tyr Leu Arg Gln Ala His Arg Lys Ile Leu Asn Tyr 
            260                 265                 270         


Pro Glu Gln Glu Glu Ala 
        275             


<210>  2572
<211>  3279
<212>  DNA
<213>  Homosapiens

<400>  2572
ccggctcgaa gcgcaacgag gaagcgtttg cggtgatccc ggcgactgcg ctggctaatg     60

cggtaccggc tagcgtggct tctgcacccc gcactgccca gcaccttccg ctcagtcctc    120

ggcgcccgcc tgccgcctcc ggagcgcctg tgtggtttcc aaaaaaagac ttacagcaaa    180

atgaataatc cagccatcaa gagaatagga aatcacatta ccaagtctcc tgaagacaag    240

cgagaatatc gagggctaga gctggccaat ggtatcaaag tacttcttat gagtgatccc    300

accacggata agtcatcagc agcacttgat gtgcacatag gttcattgtc ggatcctcca    360

aatattgctg gcttaagtca tttttgtgaa catatgcttt ttttgggaac aaagaaatac    420

cctaaagaaa atgaatacag ccagtttctc agtgagcatg caggaagttc aaatgccttt    480

actagtggag agcataccaa ttactatttt gatgtttctc atgaacacct agaaggtgcc    540

ctagacaggt ttgcacagtt ttttctgtgc cccttgttcg atgaaagttg caaagacaga    600

gaggtgaatg cagttgattc agaacatgag aagaatgtga tgaatgatgc ctggagactc    660

tttcaattgg aaaaagctac agggaatcct aaacacccct tcagtaaatt tgggacaggt    720

aacaaatata ctctggagac tagaccaaac caagaaggca ttgatgtaag acaagagcta    780

ctgaaattcc attctgctta ctattcatcc aacttaatgg ctgtttgtgt tttaggtcga    840

gaatctttag atgacttgac taatctggtg gtaaagttat tttctgaagt agagaacaaa    900

aatgttccat tgccagaatt tcctgaacac cctttccaag aagaacatct taaacaactt    960

tacaaaatag tacccattaa agatattagg aatctctatg tgacatttcc catacctgac   1020

cttcagaaat actacaaatc aaatcctggt cattatcttg gtcatctcat tgggcatgaa   1080

ggtcctggaa gtctgttatc agaacttaag tcaaagggct gggttaatac tcttgttggt   1140

gggcagaagg aaggagcccg aggttttatg ttttttatca ttaatgtgga cttgaccgag   1200

gaaggattat tacatgttga agatataatt ttgcacatgt ttcaatacat tcagaagtta   1260

cgtgcagaag gacctcaaga atgggttttc caagagtgca aggacttgaa tgctgttgct   1320

tttaggttta aagacaaaga gaggccacgg ggctatacat ctaagattgc aggaatattg   1380

cattattatc ccctagaaga ggtgctcaca gcggaatatt tactggaaga atttagacct   1440

gacttaatag agatggttct cgataaactc agaccagaaa atgtccgggt tgccatagtt   1500

tctaaatctt ttgaaggaaa aactgatcgc acagaagagt ggtatggaac ccagtacaaa   1560

caagaagcta taccggatga agtcatcaag aaatggcaaa atgctgacct gaatgggaaa   1620

tttaaacttc ctacaaagaa tgaatttatt cctacgaatt ttgagatttt accgttagaa   1680

aaagaggcga caccataccc tgctcttatt aaggatacag tcatgagcaa actttggttc   1740

aaacaagatg ataagaaaaa aaagccgaag gcttgtctca actttgaatt tttcagccca   1800

tttgcttatg tggacccctt gcactgtaac atggcctatt tgtaccttga gctcctcaaa   1860

gactcactca acgagtatgc atatgcagca gagctagcag gcttgagcta tgatctccaa   1920

aataccatct atgggatgta tctttcagtg aaaggttaca atgacaagca gccaatttta   1980

ctaaagaaga ttattgagaa aatggctacc tttgagattg atgaaaaaag atttgaaatt   2040

atcaaagaag catatatgcg atctcttaac aatttccggg ctgaacagcc tcaccagcat   2100

gccatgtact acctccgctt gctgatgact gaagtggcct ggactaaaga tgagttaaaa   2160

gaagctctgg atgatgtaac ccttcctcgc cttaaggcct tcatacctca gctcctgtca   2220

cggctgcaca ttgaagccct tctccatgga aacataacaa agcaggctgc attaggaatt   2280

atgcagatgg ttgaagacac cctcattgaa catgctcata ccaaacctct ccttccaagt   2340

cagctggttc ggtatagaga agttcagctc cctgacagag gatggtttgt ttatcagcag   2400

agaaatgaag ttcacaataa ctgtggcatc gagatatact accaaacaga catgcaaagc   2460

acctcagaga atatgtttct ggagctcttc tgtcagatta tctcggaacc ttgcttcaac   2520

accctgcgca ccaaggagca gttgggctat atcgtcttca gcgggccacg tcgagctaat   2580

ggcatacaga gcttgagatt catcatccag tcagaaaagc cacctcacta cctagaaagc   2640

agagtggaag ctttcttaat taccatggaa aagtccatag aggacatgac agaagaggcc   2700

ttccaaaaac acattcaggc attagcaatt cgtcgactag acaaaccaaa gaagctatct   2760

gctgagtgtg ctaaatactg gggagaaatc atctcccagc aatataattt tgacagagat   2820

aacactgagg ttgcatattt aaagacactt accaaggaag atatcatcaa attctacaag   2880

gaaatgttgg cagtagatgc tccaaggaga cataaggtat ccgtccatgt tcttgccagg   2940

gaaatggatt cttgtcctgt tgttggagag ttcccatgtc aaaatgacat aaatttgtca   3000

caagcaccag ccttgccaca acctgaagtg attcagaaca tgaccgaatt caagcgtggt   3060

ctgccactgt ttccccttgt gaaaccacat attaacttca tggctgcaaa actctgaaga   3120

ttccccatgc atgggaaagt gcaagtggat gcattcctga gtcttccaga gcctaagaaa   3180

atcatcttgg ccactttaat agtttctgat tcactattag agaaacaaac aaaaaattgt   3240

caaatgtcat tatgtagaaa tattataaat ccaaagtaa                          3279


<210>  2573
<211>  1019
<212>  PRT
<213>  Homosapiens

<400>  2573

Met Arg Tyr Arg Leu Ala Trp Leu Leu His Pro Ala Leu Pro Ser Thr 
1               5                   10                  15      


Phe Arg Ser Val Leu Gly Ala Arg Leu Pro Pro Pro Glu Arg Leu Cys 
            20                  25                  30          


Gly Phe Gln Lys Lys Thr Tyr Ser Lys Met Asn Asn Pro Ala Ile Lys 
        35                  40                  45              


Arg Ile Gly Asn His Ile Thr Lys Ser Pro Glu Asp Lys Arg Glu Tyr 
    50                  55                  60                  


Arg Gly Leu Glu Leu Ala Asn Gly Ile Lys Val Leu Leu Met Ser Asp 
65                  70                  75                  80  


Pro Thr Thr Asp Lys Ser Ser Ala Ala Leu Asp Val His Ile Gly Ser 
                85                  90                  95      


Leu Ser Asp Pro Pro Asn Ile Ala Gly Leu Ser His Phe Cys Glu His 
            100                 105                 110         


Met Leu Phe Leu Gly Thr Lys Lys Tyr Pro Lys Glu Asn Glu Tyr Ser 
        115                 120                 125             


Gln Phe Leu Ser Glu His Ala Gly Ser Ser Asn Ala Phe Thr Ser Gly 
    130                 135                 140                 


Glu His Thr Asn Tyr Tyr Phe Asp Val Ser His Glu His Leu Glu Gly 
145                 150                 155                 160 


Ala Leu Asp Arg Phe Ala Gln Phe Phe Leu Cys Pro Leu Phe Asp Glu 
                165                 170                 175     


Ser Cys Lys Asp Arg Glu Val Asn Ala Val Asp Ser Glu His Glu Lys 
            180                 185                 190         


Asn Val Met Asn Asp Ala Trp Arg Leu Phe Gln Leu Glu Lys Ala Thr 
        195                 200                 205             


Gly Asn Pro Lys His Pro Phe Ser Lys Phe Gly Thr Gly Asn Lys Tyr 
    210                 215                 220                 


Thr Leu Glu Thr Arg Pro Asn Gln Glu Gly Ile Asp Val Arg Gln Glu 
225                 230                 235                 240 


Leu Leu Lys Phe His Ser Ala Tyr Tyr Ser Ser Asn Leu Met Ala Val 
                245                 250                 255     


Cys Val Leu Gly Arg Glu Ser Leu Asp Asp Leu Thr Asn Leu Val Val 
            260                 265                 270         


Lys Leu Phe Ser Glu Val Glu Asn Lys Asn Val Pro Leu Pro Glu Phe 
        275                 280                 285             


Pro Glu His Pro Phe Gln Glu Glu His Leu Lys Gln Leu Tyr Lys Ile 
    290                 295                 300                 


Val Pro Ile Lys Asp Ile Arg Asn Leu Tyr Val Thr Phe Pro Ile Pro 
305                 310                 315                 320 


Asp Leu Gln Lys Tyr Tyr Lys Ser Asn Pro Gly His Tyr Leu Gly His 
                325                 330                 335     


Leu Ile Gly His Glu Gly Pro Gly Ser Leu Leu Ser Glu Leu Lys Ser 
            340                 345                 350         


Lys Gly Trp Val Asn Thr Leu Val Gly Gly Gln Lys Glu Gly Ala Arg 
        355                 360                 365             


Gly Phe Met Phe Phe Ile Ile Asn Val Asp Leu Thr Glu Glu Gly Leu 
    370                 375                 380                 


Leu His Val Glu Asp Ile Ile Leu His Met Phe Gln Tyr Ile Gln Lys 
385                 390                 395                 400 


Leu Arg Ala Glu Gly Pro Gln Glu Trp Val Phe Gln Glu Cys Lys Asp 
                405                 410                 415     


Leu Asn Ala Val Ala Phe Arg Phe Lys Asp Lys Glu Arg Pro Arg Gly 
            420                 425                 430         


Tyr Thr Ser Lys Ile Ala Gly Ile Leu His Tyr Tyr Pro Leu Glu Glu 
        435                 440                 445             


Val Leu Thr Ala Glu Tyr Leu Leu Glu Glu Phe Arg Pro Asp Leu Ile 
    450                 455                 460                 


Glu Met Val Leu Asp Lys Leu Arg Pro Glu Asn Val Arg Val Ala Ile 
465                 470                 475                 480 


Val Ser Lys Ser Phe Glu Gly Lys Thr Asp Arg Thr Glu Glu Trp Tyr 
                485                 490                 495     


Gly Thr Gln Tyr Lys Gln Glu Ala Ile Pro Asp Glu Val Ile Lys Lys 
            500                 505                 510         


Trp Gln Asn Ala Asp Leu Asn Gly Lys Phe Lys Leu Pro Thr Lys Asn 
        515                 520                 525             


Glu Phe Ile Pro Thr Asn Phe Glu Ile Leu Pro Leu Glu Lys Glu Ala 
    530                 535                 540                 


Thr Pro Tyr Pro Ala Leu Ile Lys Asp Thr Val Met Ser Lys Leu Trp 
545                 550                 555                 560 


Phe Lys Gln Asp Asp Lys Lys Lys Lys Pro Lys Ala Cys Leu Asn Phe 
                565                 570                 575     


Glu Phe Phe Ser Pro Phe Ala Tyr Val Asp Pro Leu His Cys Asn Met 
            580                 585                 590         


Ala Tyr Leu Tyr Leu Glu Leu Leu Lys Asp Ser Leu Asn Glu Tyr Ala 
        595                 600                 605             


Tyr Ala Ala Glu Leu Ala Gly Leu Ser Tyr Asp Leu Gln Asn Thr Ile 
    610                 615                 620                 


Tyr Gly Met Tyr Leu Ser Val Lys Gly Tyr Asn Asp Lys Gln Pro Ile 
625                 630                 635                 640 


Leu Leu Lys Lys Ile Ile Glu Lys Met Ala Thr Phe Glu Ile Asp Glu 
                645                 650                 655     


Lys Arg Phe Glu Ile Ile Lys Glu Ala Tyr Met Arg Ser Leu Asn Asn 
            660                 665                 670         


Phe Arg Ala Glu Gln Pro His Gln His Ala Met Tyr Tyr Leu Arg Leu 
        675                 680                 685             


Leu Met Thr Glu Val Ala Trp Thr Lys Asp Glu Leu Lys Glu Ala Leu 
    690                 695                 700                 


Asp Asp Val Thr Leu Pro Arg Leu Lys Ala Phe Ile Pro Gln Leu Leu 
705                 710                 715                 720 


Ser Arg Leu His Ile Glu Ala Leu Leu His Gly Asn Ile Thr Lys Gln 
                725                 730                 735     


Ala Ala Leu Gly Ile Met Gln Met Val Glu Asp Thr Leu Ile Glu His 
            740                 745                 750         


Ala His Thr Lys Pro Leu Leu Pro Ser Gln Leu Val Arg Tyr Arg Glu 
        755                 760                 765             


Val Gln Leu Pro Asp Arg Gly Trp Phe Val Tyr Gln Gln Arg Asn Glu 
    770                 775                 780                 


Val His Asn Asn Cys Gly Ile Glu Ile Tyr Tyr Gln Thr Asp Met Gln 
785                 790                 795                 800 


Ser Thr Ser Glu Asn Met Phe Leu Glu Leu Phe Cys Gln Ile Ile Ser 
                805                 810                 815     


Glu Pro Cys Phe Asn Thr Leu Arg Thr Lys Glu Gln Leu Gly Tyr Ile 
            820                 825                 830         


Val Phe Ser Gly Pro Arg Arg Ala Asn Gly Ile Gln Ser Leu Arg Phe 
        835                 840                 845             


Ile Ile Gln Ser Glu Lys Pro Pro His Tyr Leu Glu Ser Arg Val Glu 
    850                 855                 860                 


Ala Phe Leu Ile Thr Met Glu Lys Ser Ile Glu Asp Met Thr Glu Glu 
865                 870                 875                 880 


Ala Phe Gln Lys His Ile Gln Ala Leu Ala Ile Arg Arg Leu Asp Lys 
                885                 890                 895     


Pro Lys Lys Leu Ser Ala Glu Cys Ala Lys Tyr Trp Gly Glu Ile Ile 
            900                 905                 910         


Ser Gln Gln Tyr Asn Phe Asp Arg Asp Asn Thr Glu Val Ala Tyr Leu 
        915                 920                 925             


Lys Thr Leu Thr Lys Glu Asp Ile Ile Lys Phe Tyr Lys Glu Met Leu 
    930                 935                 940                 


Ala Val Asp Ala Pro Arg Arg His Lys Val Ser Val His Val Leu Ala 
945                 950                 955                 960 


Arg Glu Met Asp Ser Cys Pro Val Val Gly Glu Phe Pro Cys Gln Asn 
                965                 970                 975     


Asp Ile Asn Leu Ser Gln Ala Pro Ala Leu Pro Gln Pro Glu Val Ile 
            980                 985                 990         


Gln Asn Met Thr Glu Phe Lys Arg  Gly Leu Pro Leu Phe  Pro Leu Val 
        995                 1000                 1005             


Lys Pro  His Ile Asn Phe Met  Ala Ala Lys Leu 
    1010                 1015                 


<210>  2574
<211>  4908
<212>  DNA
<213>  Homosapiens

<400>  2574
acctgcgtgc agtcggtcct ccaggccacg cagcgcccga gagtaccagg gagactccgg     60

cccctgtcgg cgccaagccc ctccgcccct cacagcgccc aggtccgcgg ccgggccttg    120

attttttggc ggggaccgtc atggcgtcgc agccaaattc gtctgcgaag aagaaagagg    180

agaaggggaa gaacatccag gtggtggtga gatgcagacc atttaatttg gcagagcgga    240

aagctagcgc ccattcaata gtagaatgtg atcctgtacg aaaagaagtt agtgtacgaa    300

ctggaggatt ggctgacaag agctcaagga aaacatacac ttttgatatg gtgtttggag    360

catctactaa acagattgat gtttaccgaa gtgttgtttg tccaattctg gatgaagtta    420

ttatgggcta taattgcact atctttgcgt atggccaaac tggcactgga aaaactttta    480

caatggaagg tgaaaggtca cctaatgaag agtatacctg ggaagaggat cccttggctg    540

gtataattcc acgtaccctt catcaaattt ttgagaaact tactgataat ggtactgaat    600

tttcagtcaa agtgtctctg ttggagatct ataatgaaga gctttttgat cttcttaatc    660

catcatctga tgtttctgag agactacaga tgtttgatga tccccgtaac aagagaggag    720

tgataattaa aggtttagaa gaaattacag tacacaacaa ggatgaagtc tatcaaattt    780

tagaaaaggg ggcagcaaaa aggacaactg cagctactct gatgaatgca tactctagtc    840

gttcccactc agttttctct gttacaatac atatgaaaga aactacgatt gatggagaag    900

agcttgttaa aatcggaaag ttgaacttgg ttgatcttgc aggaagtgaa aacattggcc    960

gttctggagc tgttgataag agagctcggg aagctggaaa tataaatcaa tccctgttga   1020

ctttgggaag ggtcattact gcccttgtag aaagaacacc tcatgttcct tatcgagaat   1080

ctaaactaac tagaatcctc caggattctc ttggagggcg tacaagaaca tctataattg   1140

caacaatttc tcctgcatct ctcaatcttg aggaaactct gagtacattg gaatatgctc   1200

atagagcaaa gaacatattg aataagcctg aagtgaatca gaaactcacc aaaaaagctc   1260

ttattaagga gtatacggag gagatagaac gtttaaaacg agatcttgct gcagcccgtg   1320

agaaaaatgg agtgtatatt tctgaagaaa attttagagt catgagtgga aaattaactg   1380

ttcaagaaga gcagattgta gaattgattg aaaaaattgg tgctgttgag gaggagctga   1440

atagggttac agagttgttt atggataata aaaatgaact tgaccagtgt aaatctgacc   1500

tgcaaaataa aacacaagaa cttgaaacca ctcaaaaaca tttgcaagaa actaaattac   1560

aacttgttaa agaagaatat atcacatcag ctttggaaag tactgaggag aaacttcatg   1620

atgctgccag caagctgctt aacacagttg aagaaactac aaaagatgta tctggtctcc   1680

attccaaact ggatcgtaag aaggcagttg accaacacaa tgcagaagct caggatattt   1740

ttggcaaaaa cctgaatagt ctgtttaata atatggaaga attaattaag gatggcagct   1800

caaagcaaaa ggccatgcta gaagtacata agaccttatt tggtaatctg ctgtcttcca   1860

gtgtctctgc attagatacc attactacag tagcacttgg atctctcaca tctattccag   1920

aaaatgtgtc tactcatgtt tctcagattt ttaatatgat actaaaagaa caatcattag   1980

cagcagaaag taaaactgta ctacaggaat tgattaatgt actcaagact gatcttctaa   2040

gttcactgga aatgatttta tccccaactg tggtgtctat actgaaaatc aatagtcaac   2100

taaagcatat tttcaagact tcattgacag tggccgataa gatagaagat caaaaaaagg   2160

aactagatgg ctttctcagt atactgtgta acaatctaca tgaactacaa gaaaatacca   2220

tttgttcctt ggttgagtca caaaagcaat gtggaaacct aactgaagac ctgaagacaa   2280

taaagcagac ccattcccag gaactttgca agttaatgaa tctttggaca gagagattct   2340

gtgctttgga ggaaaagtgt gaaaatatac agaaaccact tagtagtgtc caggaaaata   2400

tacagcagaa atctaaggat atagtcaaca aaatgacttt tcacagtcaa aaattttgtg   2460

ctgattctga tggcttctca caggaactca gaaattttaa ccaagaaggt acaaaattgg   2520

ttgaagaatc tgtgaaacac tctgataaac tcaatggcaa cctggaaaaa atatctcaag   2580

agactgaaca gagatgtgaa tctctgaaca caagaacagt ttatttttct gaacagtggg   2640

tatcttcctt aaatgaaagg gaacaggaac ttcacaactt attggaggtt gtaagccaat   2700

gttgtgaggc ttcaagttca gacatcactg agaaatcaga tggacgtaag gcagctcatg   2760

agaaacagca taacattttt cttgatcaga tgactattga tgaagataaa ttgatagcac   2820

aaaatctaga acttaatgaa accataaaaa ttggtttgac taagcttaat tgctttctgg   2880

aacaggatct gaaactggat atcccaacag gtacgacacc acagaggaaa agttatttat   2940

acccatcaac actggtaaga actgaaccac gtgaacatct ccttgatcag ctgaaaagga   3000

aacagcctga gctgttaatg atgctaaact gttcagaaaa caacaaagaa gagacaattc   3060

cggatgtgga tgtagaagag gcagttctgg ggcagtatac tgaagaacct ctaagtcaag   3120

agccatctgt agatgctggt gtggattgtt catcaattgg cggggttcca tttttccagc   3180

ataaaaaatc acatggaaaa gacaaagaaa acagaggcat taacacactg gagaggtcta   3240

aagtggaaga aactacagag cacttggtta caaagagcag attacctctg cgagcccaga   3300

tcaaccttta attcacttgg gggttggcaa ttttattttt aaagaaaact taaaaataaa   3360

acctgaaacc ccagaacttg agccttgtgt atagatttta aaagaatata tatatcagcc   3420

gggcgcggtg gctcatgcct gtaatcccag cactttggga ggctgaggcg ggtggattgc   3480

ttgagcccag gagtttgaga ccagcctggc caacgtggca aaacctcgtc tctgttaaaa   3540

attagccggg cgtggtggca cactcctgta atcccagcta ctggggaggc tgaggcacga   3600

gaatcacttg aacccaggaa gcggggttgc agtgagccaa aggtacacca ctacactcca   3660

gcctgggcaa cagagcaaga ctcggtctca aaaacaaaat ttaaaaaaga tataaggcag   3720

tactgtaaat tcagttgaat tttgatatct acccattttt ctgtcatccc tatagttcac   3780

tttgtattaa attgggtttc atttgggatt tgcaatgtaa atacgtattt ctagttttca   3840

tataaagtag ttcttttata acaaatgaaa agtatttttc ttgtatatta ttaagtaatg   3900

aatatataag aactgtactc ttctcagctt gagcttaaca taggtaaata tcaccaacat   3960

ctgtccttag aaaggaccat ctcatgtttt ttttcttgct atgacttgtg tattttcttg   4020

catcctccct agacttccct atttcgcttt ctcctcggct cactttctcc ctttttattt   4080

ttcaccaaac catttgtaga gctacaaaac ctatcctttc ttattttcag tagtcagaat   4140

tttatctaga aatcttttaa caccttttta gtggttattt ctaaaatcac tgtcaacaat   4200

aaatctaacc ctagttgtat ccctccttta agtatttaaa acttgttgcc ccaaatgtga   4260

aagcatttaa ttcctttaag aggcctaact cattcaccct gacagagttc acaaaaagcc   4320

cactttagag tatacattgc tattatggga gaccacccag acatctgact aatggctctg   4380

tgccacactc caagacctgt gccttttaga gaagctcaca atgatttaag gactgtttga   4440

aacttccaat tatgtctata atttatattc ttttgtttac atgatgaaac tttttgttgt   4500

tgcttgtttg tatataatac aatgtgtaca tgtatctttt tctcgattca aatcttaacc   4560

cttaggactc tggtattttt gatctggcaa ccatatttct ggaagttgag atgtttcagc   4620

ttgaagaacc aaaacagaag gaatatgtac aaagaataaa ttttctgctc acgatgagtt   4680

tagtgtgtaa agtttagaga catctgactt tgatagctaa attaaaccaa accctattga   4740

agaattgaat atatgctact tcaagaaact aaattgatct cgtagaatta tcttaataaa   4800

ataatggcta taatttctct gcaaaatcag atgtcagcat aagcgatgga taatacctaa   4860

taaactgccc tcagtaaatc catggttaat aaatgtggtt tctacatt                4908


<210>  2575
<211>  1056
<212>  PRT
<213>  Homosapiens

<400>  2575

Met Ala Ser Gln Pro Asn Ser Ser Ala Lys Lys Lys Glu Glu Lys Gly 
1               5                   10                  15      


Lys Asn Ile Gln Val Val Val Arg Cys Arg Pro Phe Asn Leu Ala Glu 
            20                  25                  30          


Arg Lys Ala Ser Ala His Ser Ile Val Glu Cys Asp Pro Val Arg Lys 
        35                  40                  45              


Glu Val Ser Val Arg Thr Gly Gly Leu Ala Asp Lys Ser Ser Arg Lys 
    50                  55                  60                  


Thr Tyr Thr Phe Asp Met Val Phe Gly Ala Ser Thr Lys Gln Ile Asp 
65                  70                  75                  80  


Val Tyr Arg Ser Val Val Cys Pro Ile Leu Asp Glu Val Ile Met Gly 
                85                  90                  95      


Tyr Asn Cys Thr Ile Phe Ala Tyr Gly Gln Thr Gly Thr Gly Lys Thr 
            100                 105                 110         


Phe Thr Met Glu Gly Glu Arg Ser Pro Asn Glu Glu Tyr Thr Trp Glu 
        115                 120                 125             


Glu Asp Pro Leu Ala Gly Ile Ile Pro Arg Thr Leu His Gln Ile Phe 
    130                 135                 140                 


Glu Lys Leu Thr Asp Asn Gly Thr Glu Phe Ser Val Lys Val Ser Leu 
145                 150                 155                 160 


Leu Glu Ile Tyr Asn Glu Glu Leu Phe Asp Leu Leu Asn Pro Ser Ser 
                165                 170                 175     


Asp Val Ser Glu Arg Leu Gln Met Phe Asp Asp Pro Arg Asn Lys Arg 
            180                 185                 190         


Gly Val Ile Ile Lys Gly Leu Glu Glu Ile Thr Val His Asn Lys Asp 
        195                 200                 205             


Glu Val Tyr Gln Ile Leu Glu Lys Gly Ala Ala Lys Arg Thr Thr Ala 
    210                 215                 220                 


Ala Thr Leu Met Asn Ala Tyr Ser Ser Arg Ser His Ser Val Phe Ser 
225                 230                 235                 240 


Val Thr Ile His Met Lys Glu Thr Thr Ile Asp Gly Glu Glu Leu Val 
                245                 250                 255     


Lys Ile Gly Lys Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Asn Ile 
            260                 265                 270         


Gly Arg Ser Gly Ala Val Asp Lys Arg Ala Arg Glu Ala Gly Asn Ile 
        275                 280                 285             


Asn Gln Ser Leu Leu Thr Leu Gly Arg Val Ile Thr Ala Leu Val Glu 
    290                 295                 300                 


Arg Thr Pro His Val Pro Tyr Arg Glu Ser Lys Leu Thr Arg Ile Leu 
305                 310                 315                 320 


Gln Asp Ser Leu Gly Gly Arg Thr Arg Thr Ser Ile Ile Ala Thr Ile 
                325                 330                 335     


Ser Pro Ala Ser Leu Asn Leu Glu Glu Thr Leu Ser Thr Leu Glu Tyr 
            340                 345                 350         


Ala His Arg Ala Lys Asn Ile Leu Asn Lys Pro Glu Val Asn Gln Lys 
        355                 360                 365             


Leu Thr Lys Lys Ala Leu Ile Lys Glu Tyr Thr Glu Glu Ile Glu Arg 
    370                 375                 380                 


Leu Lys Arg Asp Leu Ala Ala Ala Arg Glu Lys Asn Gly Val Tyr Ile 
385                 390                 395                 400 


Ser Glu Glu Asn Phe Arg Val Met Ser Gly Lys Leu Thr Val Gln Glu 
                405                 410                 415     


Glu Gln Ile Val Glu Leu Ile Glu Lys Ile Gly Ala Val Glu Glu Glu 
            420                 425                 430         


Leu Asn Arg Val Thr Glu Leu Phe Met Asp Asn Lys Asn Glu Leu Asp 
        435                 440                 445             


Gln Cys Lys Ser Asp Leu Gln Asn Lys Thr Gln Glu Leu Glu Thr Thr 
    450                 455                 460                 


Gln Lys His Leu Gln Glu Thr Lys Leu Gln Leu Val Lys Glu Glu Tyr 
465                 470                 475                 480 


Ile Thr Ser Ala Leu Glu Ser Thr Glu Glu Lys Leu His Asp Ala Ala 
                485                 490                 495     


Ser Lys Leu Leu Asn Thr Val Glu Glu Thr Thr Lys Asp Val Ser Gly 
            500                 505                 510         


Leu His Ser Lys Leu Asp Arg Lys Lys Ala Val Asp Gln His Asn Ala 
        515                 520                 525             


Glu Ala Gln Asp Ile Phe Gly Lys Asn Leu Asn Ser Leu Phe Asn Asn 
    530                 535                 540                 


Met Glu Glu Leu Ile Lys Asp Gly Ser Ser Lys Gln Lys Ala Met Leu 
545                 550                 555                 560 


Glu Val His Lys Thr Leu Phe Gly Asn Leu Leu Ser Ser Ser Val Ser 
                565                 570                 575     


Ala Leu Asp Thr Ile Thr Thr Val Ala Leu Gly Ser Leu Thr Ser Ile 
            580                 585                 590         


Pro Glu Asn Val Ser Thr His Val Ser Gln Ile Phe Asn Met Ile Leu 
        595                 600                 605             


Lys Glu Gln Ser Leu Ala Ala Glu Ser Lys Thr Val Leu Gln Glu Leu 
    610                 615                 620                 


Ile Asn Val Leu Lys Thr Asp Leu Leu Ser Ser Leu Glu Met Ile Leu 
625                 630                 635                 640 


Ser Pro Thr Val Val Ser Ile Leu Lys Ile Asn Ser Gln Leu Lys His 
                645                 650                 655     


Ile Phe Lys Thr Ser Leu Thr Val Ala Asp Lys Ile Glu Asp Gln Lys 
            660                 665                 670         


Lys Glu Leu Asp Gly Phe Leu Ser Ile Leu Cys Asn Asn Leu His Glu 
        675                 680                 685             


Leu Gln Glu Asn Thr Ile Cys Ser Leu Val Glu Ser Gln Lys Gln Cys 
    690                 695                 700                 


Gly Asn Leu Thr Glu Asp Leu Lys Thr Ile Lys Gln Thr His Ser Gln 
705                 710                 715                 720 


Glu Leu Cys Lys Leu Met Asn Leu Trp Thr Glu Arg Phe Cys Ala Leu 
                725                 730                 735     


Glu Glu Lys Cys Glu Asn Ile Gln Lys Pro Leu Ser Ser Val Gln Glu 
            740                 745                 750         


Asn Ile Gln Gln Lys Ser Lys Asp Ile Val Asn Lys Met Thr Phe His 
        755                 760                 765             


Ser Gln Lys Phe Cys Ala Asp Ser Asp Gly Phe Ser Gln Glu Leu Arg 
    770                 775                 780                 


Asn Phe Asn Gln Glu Gly Thr Lys Leu Val Glu Glu Ser Val Lys His 
785                 790                 795                 800 


Ser Asp Lys Leu Asn Gly Asn Leu Glu Lys Ile Ser Gln Glu Thr Glu 
                805                 810                 815     


Gln Arg Cys Glu Ser Leu Asn Thr Arg Thr Val Tyr Phe Ser Glu Gln 
            820                 825                 830         


Trp Val Ser Ser Leu Asn Glu Arg Glu Gln Glu Leu His Asn Leu Leu 
        835                 840                 845             


Glu Val Val Ser Gln Cys Cys Glu Ala Ser Ser Ser Asp Ile Thr Glu 
    850                 855                 860                 


Lys Ser Asp Gly Arg Lys Ala Ala His Glu Lys Gln His Asn Ile Phe 
865                 870                 875                 880 


Leu Asp Gln Met Thr Ile Asp Glu Asp Lys Leu Ile Ala Gln Asn Leu 
                885                 890                 895     


Glu Leu Asn Glu Thr Ile Lys Ile Gly Leu Thr Lys Leu Asn Cys Phe 
            900                 905                 910         


Leu Glu Gln Asp Leu Lys Leu Asp Ile Pro Thr Gly Thr Thr Pro Gln 
        915                 920                 925             


Arg Lys Ser Tyr Leu Tyr Pro Ser Thr Leu Val Arg Thr Glu Pro Arg 
    930                 935                 940                 


Glu His Leu Leu Asp Gln Leu Lys Arg Lys Gln Pro Glu Leu Leu Met 
945                 950                 955                 960 


Met Leu Asn Cys Ser Glu Asn Asn Lys Glu Glu Thr Ile Pro Asp Val 
                965                 970                 975     


Asp Val Glu Glu Ala Val Leu Gly Gln Tyr Thr Glu Glu Pro Leu Ser 
            980                 985                 990         


Gln Glu Pro Ser Val Asp Ala Gly  Val Asp Cys Ser Ser  Ile Gly Gly 
        995                 1000                 1005             


Val Pro  Phe Phe Gln His Lys  Lys Ser His Gly Lys  Asp Lys Glu 
    1010                 1015                 1020             


Asn Arg  Gly Ile Asn Thr Leu  Glu Arg Ser Lys Val  Glu Glu Thr 
    1025                 1030                 1035             


Thr Glu  His Leu Val Thr Lys  Ser Arg Leu Pro Leu  Arg Ala Gln 
    1040                 1045                 1050             


Ile Asn  Leu 
    1055     


<210>  2576
<211>  1753
<212>  DNA
<213>  Homosapiens

<400>  2576
gcgcgggcca gcagctctgc gaggggccgg agcgcggcgg agccatgcag tacccgcacc     60

ccgggccggc ggcgggcgcc gtgggggtgc cgctgtacgc gcccacgccg ctgctgcaac    120

ccgcacaccc gacgcccttt tacatcgagg acatcctggg ccgcgggccc gccgcgccca    180

cgcccgcccc cacgctgccg tcccccaact cctccttcac cagcctcgtg tccccctacc    240

ggaccccggt gtacgagccc acgccgatcc atccagcctt ctcgcaccac tccgccgccg    300

cgctggccgc tgcctacgga cccggcggct tcgggggccc tctgtacccc ttcccgcgga    360

cggtgaacga ctacacgcac gccctgctcc gccacgaccc cctgggcaaa cctctactct    420

ggagcccctt cttgcagagg cctctgcata aaaggaaagg cggccaggtg agattctcca    480

acgaccagac catcgagctg gagaagaaat tcgagacgca gaaatatctc tctccgcccg    540

agaggaagcg tctggccaag atgctgcagc tcagcgagag acaggtcaaa acctggtttc    600

agaatcgacg cgctaaatgg aggagactaa aacaggagaa ccctcaaagc aataaaaaag    660

aagaactgga aagtttggac agttcctgtg atcagaggca agatttgccc agtgaacaga    720

ataaaggtgc ttctttggat agctctcaat gttcgccctc ccctgcctcc caggaagacc    780

ttgaatcaga gatttcagag gattctgatc aggaagtgga cattgagggc gataaaagct    840

attttaatgc tggatgatga ccactggcat tggcatgttc agaaaactgg atttaggaat    900

aatgttttgc tacagaaaat cttcatagaa gaactggaag gctatataag aaagggaatc    960

aattctctgg tattctggaa acctaaaaat atttggtgca ctgctcaatt aacaaaccta   1020

catggagacc ttaattttga cttaacaaat agtttatgta ctgctcttag gttgttttga   1080

taaagtgaca ttatagtgat taaattcttc cccctttaaa aaaacagtta gtggttttca   1140

ctatttataa aaaattaatt ttgaactttt tgttaaattt ttaagttata gctttaaagg   1200

ttttaatagg accttcttga acgacttttc tgtaatctgt ttatctccca cttaatggaa   1260

aggcaaaggg gtaccccaaa tccagaggtg cctacatttc aggcagcctt ggagtatttt   1320

aaaaggaaaa cattctttac ttttatatga cattcttata ctgctgtctc aaatccaaaa   1380

acatttcaga gctcttgtct cagagatgtg tgttcttttt gtcagagata tggttgatga   1440

gaatcttaaa tgcttgtttt gcactatcac ttagtacctg tttgaccaag gtgttaaggg   1500

gatagtacct cccaattcaa gcagagaaac tgacctgact aaagttaatc gcagatgaac   1560

tagaagtcac aggttaatta aatgtaagta gattgtagat actgttttat atcaaacaat   1620

gtttataatg tgtatataga attgttcact gtaaaaaaaa tggccaaaat gtgttttttt   1680

tttaataagt aacttgacta taaaataaag ccgtccgtgg gacgactgac ctcgttgcaa   1740

aaaaaaaaaa aaa                                                      1753


<210>  2577
<211>  270
<212>  PRT
<213>  Homosapiens

<400>  2577

Met Gln Tyr Pro His Pro Gly Pro Ala Ala Gly Ala Val Gly Val Pro 
1               5                   10                  15      


Leu Tyr Ala Pro Thr Pro Leu Leu Gln Pro Ala His Pro Thr Pro Phe 
            20                  25                  30          


Tyr Ile Glu Asp Ile Leu Gly Arg Gly Pro Ala Ala Pro Thr Pro Ala 
        35                  40                  45              


Pro Thr Leu Pro Ser Pro Asn Ser Ser Phe Thr Ser Leu Val Ser Pro 
    50                  55                  60                  


Tyr Arg Thr Pro Val Tyr Glu Pro Thr Pro Ile His Pro Ala Phe Ser 
65                  70                  75                  80  


His His Ser Ala Ala Ala Leu Ala Ala Ala Tyr Gly Pro Gly Gly Phe 
                85                  90                  95      


Gly Gly Pro Leu Tyr Pro Phe Pro Arg Thr Val Asn Asp Tyr Thr His 
            100                 105                 110         


Ala Leu Leu Arg His Asp Pro Leu Gly Lys Pro Leu Leu Trp Ser Pro 
        115                 120                 125             


Phe Leu Gln Arg Pro Leu His Lys Arg Lys Gly Gly Gln Val Arg Phe 
    130                 135                 140                 


Ser Asn Asp Gln Thr Ile Glu Leu Glu Lys Lys Phe Glu Thr Gln Lys 
145                 150                 155                 160 


Tyr Leu Ser Pro Pro Glu Arg Lys Arg Leu Ala Lys Met Leu Gln Leu 
                165                 170                 175     


Ser Glu Arg Gln Val Lys Thr Trp Phe Gln Asn Arg Arg Ala Lys Trp 
            180                 185                 190         


Arg Arg Leu Lys Gln Glu Asn Pro Gln Ser Asn Lys Lys Glu Glu Leu 
        195                 200                 205             


Glu Ser Leu Asp Ser Ser Cys Asp Gln Arg Gln Asp Leu Pro Ser Glu 
    210                 215                 220                 


Gln Asn Lys Gly Ala Ser Leu Asp Ser Ser Gln Cys Ser Pro Ser Pro 
225                 230                 235                 240 


Ala Ser Gln Glu Asp Leu Glu Ser Glu Ile Ser Glu Asp Ser Asp Gln 
                245                 250                 255     


Glu Val Asp Ile Glu Gly Asp Lys Ser Tyr Phe Asn Ala Gly 
            260                 265                 270 


<210>  2578
<211>  3568
<212>  DNA
<213>  Homosapiens

<400>  2578
ctggaaaatt aggggcctgt cgagcgatgt tggaagaaga aacagatcaa acctatgaga     60

atgtcctggc tgagattcag tctttcgaac tgcctgttga agctacttta aggtctgtgt    120

atgatgacca accaaatgcg cacaagaagt ttatggaaaa gttagatgct tgtatccgta    180

atcatgacaa ggaaattgaa aagatgtgta attttcatca tcagggtttt gtagatgcta    240

ttacagaact ccttaaagta aggactgatg cagaaaaact gaaggtgcaa gttactgata    300

ccaaccgaag gtttcaagat gctggaaaag aggtgatagt ccacacagaa gatatcattc    360

gatgtagaat tcagcagaga aatattacaa ctgtagtaga aaaattgcag ttatgccttc    420

ctgtgctaga aatgtacagt aagctgaaag aacagatgag tgccaaaagg tactattctg    480

ccctaaaaac tatggaacaa ttagagaatg tgtactttcc ctgggttagt caataccggt    540

tttgtcagct catgatagaa aatcttccca aactccgtga ggatattaaa gaaatctcca    600

tgtctgatct caaagacttt ttggaaagta ttcgaaaaca ttctgacaaa ataggtgaaa    660

cagcaatgaa acaggcacag catcagaaaa ccttcagtgt ttctctgcag aaacaaaata    720

aaatgaaatt tgggaaaaat atgtatataa atcgtgatag aattccagag gaaaggaatg    780

aaactgtatt gaaacattca cttgaagaag aggatgagaa tgaagaagag atcttaactg    840

ttcaggatct tgttgatttt tcccctgttt atcgatgttt gcacatttat tctgttttgg    900

gtgacgagga aacatttgaa aactattatc gaaaacaaag aaagaaacaa gcaagactgg    960

tattgcaacc ccagtcgaat atgcatgaaa cagttgatgg ctatagaaga tatttcactc   1020

aaattgtagg gttctttgtg gtagaagatc acattttaca tgtgacccaa ggattagtaa   1080

ccagggcata cactgatgaa ctttggaaca tggccctctc aaagataatt gctgtcctta   1140

gagctcattc atcctattgc actgatcctg atcttgttct ggagctgaag aatcttactg   1200

taatatttgc agatacttta cagggttatg gttttccagt gaaccgactt tttgaccttt   1260

tatttgaaat aagagaccaa tacaatgaaa cactgcttaa gaaatgggct ggagttttca   1320

gggacatttt tgaagaagat aattacagcc ccatccctgt tgtcaatgaa gaagaatata   1380

aaattgtcat cagcaaattt ccctttcaag atccagacct tgaaaagcag tctttcccaa   1440

agaaattccc catgtctcag tcagtgcctc atatttacat tcaagttaaa gaatttattt   1500

atgccagcct taaattttca gagtcactac accggagctc aacagaaata gacgatatgc   1560

ttagaaaatc aacaaatctg ctgctgacca gaactttgag tagctgttta ctgaacctta   1620

ttagaaaacc tcatataggt ttgacagagc tggtacaaat catcataaac acaacacacc   1680

tggagcaagc ttgtaaatat cttgaggact ttataactaa cattacaaat atttcccaag   1740

aaactgttca tactacaaga ctttatggac tttctacttt caaggatgct cgacatgcag   1800

cagaaggaga aatatatacc aaactgaatc aaaaaattga tgaatttgtt cagcttgctg   1860

attatgactg gacaatgtct gagccagatg gaagagctag tggttattta atggacctta   1920

taaatttttt gagaagcatc tttcaagtgt ttactcattt gcctgggaaa gttgctcaga   1980

cagcttgcat gtcagcctgc cagcatctgt caacatcctt aatgcagatg ctactggaca   2040

gtgagttaaa acaaataagc atgggagctg ttcagcagtt taacttagat gtcatacagt   2100

gtgaattgtt tgccagctct gagcctgtgc caggattcca gggggatacc ctgcagctag   2160

cattcattga cctcagacaa ctccttgacc tgtttatggt ttgggattgg tctacttacc   2220

tagctgatta tgggcagcca gcttctaagt accttcgggt gaatccaaac acagccctta   2280

ctcttttgga gaagatgaag gatactagca aaaagaacaa tatatttgct cagttcagga   2340

agaatgatcg agacaaacag aagttgatag agacagtcgt gaaacagctg agaagtttgg   2400

tgaatggtat gtcccagcac atgtagacct cacatggctt gcactcagtg acaccaaatc   2460

catgattcaa tgttgatctt gagcaagtat tggtcatgat acagtaattt gtttacagaa   2520

tccaaaaata caatagagaa gatacatgag ggcttaaaca agaaatagta ataaatatca   2580

tttgtatgga tttttaaata atcgaatact attttatata tggaaaaaaa tgaccatttt   2640

ttcactttta ggggaaaatg caaaagtgta atacataaat tgtcacaaat tatacctgaa   2700

attgattaca aatacatttg aaaaacatat gcctctactc ataagtattt ttttctattt   2760

agacttgaat gataatctgt tttttgatca gtatatggct ttggaattca atcatgtctg   2820

atatggtagt atttcactac cattttctga cttttagctt ttattttcac ctcaatgtga   2880

tttaagcaga ccaaaatttc taattctgct aattctgaag gggaaataga caaatcttaa   2940

aagctgcctg aaatcaaact tgatttaact cagtaagaat gtgaattatt tgttctactt   3000

gggtggttta atttaatcgt tctgaatatg aacaaaaggt tttggatttt ctaaagatgc   3060

agtgttgttt ctgttcatca gggttaatat ttctaactat attgcttgta ggtgacccca   3120

ttctggattt gtttggtttg gtttggttcc agttaaaaga gaggacagga actaaatggg   3180

gctaaccact tcaggtgcag cttgtgcgag ggtagatggt tcctgcacac agaagttacc   3240

acaggggtca ggttactttc ttcaaatagc agatttcagt actttatcct cattgtggaa   3300

acaagccaaa ccaaatgaac tctggaaaac ctaaaacaaa tgtacatttt cctttgtgta   3360

tgtttccgtg gtccaaatgg caatataaat ccagtcttta ttctcccttt gttgtattta   3420

tgctgaatct tccctttgcc ttttcaggat ttaggcctgt aagaaactat gcctgattct   3480

gtaaaataag tgtaaagaat tatatgtaca tctctggatt ttgtgatgaa atattaaaaa   3540

tattgagcaa gttgttgaaa atgcaaaa                                      3568


<210>  2579
<211>  799
<212>  PRT
<213>  Homosapiens

<400>  2579

Met Leu Glu Glu Glu Thr Asp Gln Thr Tyr Glu Asn Val Leu Ala Glu 
1               5                   10                  15      


Ile Gln Ser Phe Glu Leu Pro Val Glu Ala Thr Leu Arg Ser Val Tyr 
            20                  25                  30          


Asp Asp Gln Pro Asn Ala His Lys Lys Phe Met Glu Lys Leu Asp Ala 
        35                  40                  45              


Cys Ile Arg Asn His Asp Lys Glu Ile Glu Lys Met Cys Asn Phe His 
    50                  55                  60                  


His Gln Gly Phe Val Asp Ala Ile Thr Glu Leu Leu Lys Val Arg Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Leu Lys Val Gln Val Thr Asp Thr Asn Arg Arg Phe 
                85                  90                  95      


Gln Asp Ala Gly Lys Glu Val Ile Val His Thr Glu Asp Ile Ile Arg 
            100                 105                 110         


Cys Arg Ile Gln Gln Arg Asn Ile Thr Thr Val Val Glu Lys Leu Gln 
        115                 120                 125             


Leu Cys Leu Pro Val Leu Glu Met Tyr Ser Lys Leu Lys Glu Gln Met 
    130                 135                 140                 


Ser Ala Lys Arg Tyr Tyr Ser Ala Leu Lys Thr Met Glu Gln Leu Glu 
145                 150                 155                 160 


Asn Val Tyr Phe Pro Trp Val Ser Gln Tyr Arg Phe Cys Gln Leu Met 
                165                 170                 175     


Ile Glu Asn Leu Pro Lys Leu Arg Glu Asp Ile Lys Glu Ile Ser Met 
            180                 185                 190         


Ser Asp Leu Lys Asp Phe Leu Glu Ser Ile Arg Lys His Ser Asp Lys 
        195                 200                 205             


Ile Gly Glu Thr Ala Met Lys Gln Ala Gln His Gln Lys Thr Phe Ser 
    210                 215                 220                 


Val Ser Leu Gln Lys Gln Asn Lys Met Lys Phe Gly Lys Asn Met Tyr 
225                 230                 235                 240 


Ile Asn Arg Asp Arg Ile Pro Glu Glu Arg Asn Glu Thr Val Leu Lys 
                245                 250                 255     


His Ser Leu Glu Glu Glu Asp Glu Asn Glu Glu Glu Ile Leu Thr Val 
            260                 265                 270         


Gln Asp Leu Val Asp Phe Ser Pro Val Tyr Arg Cys Leu His Ile Tyr 
        275                 280                 285             


Ser Val Leu Gly Asp Glu Glu Thr Phe Glu Asn Tyr Tyr Arg Lys Gln 
    290                 295                 300                 


Arg Lys Lys Gln Ala Arg Leu Val Leu Gln Pro Gln Ser Asn Met His 
305                 310                 315                 320 


Glu Thr Val Asp Gly Tyr Arg Arg Tyr Phe Thr Gln Ile Val Gly Phe 
                325                 330                 335     


Phe Val Val Glu Asp His Ile Leu His Val Thr Gln Gly Leu Val Thr 
            340                 345                 350         


Arg Ala Tyr Thr Asp Glu Leu Trp Asn Met Ala Leu Ser Lys Ile Ile 
        355                 360                 365             


Ala Val Leu Arg Ala His Ser Ser Tyr Cys Thr Asp Pro Asp Leu Val 
    370                 375                 380                 


Leu Glu Leu Lys Asn Leu Thr Val Ile Phe Ala Asp Thr Leu Gln Gly 
385                 390                 395                 400 


Tyr Gly Phe Pro Val Asn Arg Leu Phe Asp Leu Leu Phe Glu Ile Arg 
                405                 410                 415     


Asp Gln Tyr Asn Glu Thr Leu Leu Lys Lys Trp Ala Gly Val Phe Arg 
            420                 425                 430         


Asp Ile Phe Glu Glu Asp Asn Tyr Ser Pro Ile Pro Val Val Asn Glu 
        435                 440                 445             


Glu Glu Tyr Lys Ile Val Ile Ser Lys Phe Pro Phe Gln Asp Pro Asp 
    450                 455                 460                 


Leu Glu Lys Gln Ser Phe Pro Lys Lys Phe Pro Met Ser Gln Ser Val 
465                 470                 475                 480 


Pro His Ile Tyr Ile Gln Val Lys Glu Phe Ile Tyr Ala Ser Leu Lys 
                485                 490                 495     


Phe Ser Glu Ser Leu His Arg Ser Ser Thr Glu Ile Asp Asp Met Leu 
            500                 505                 510         


Arg Lys Ser Thr Asn Leu Leu Leu Thr Arg Thr Leu Ser Ser Cys Leu 
        515                 520                 525             


Leu Asn Leu Ile Arg Lys Pro His Ile Gly Leu Thr Glu Leu Val Gln 
    530                 535                 540                 


Ile Ile Ile Asn Thr Thr His Leu Glu Gln Ala Cys Lys Tyr Leu Glu 
545                 550                 555                 560 


Asp Phe Ile Thr Asn Ile Thr Asn Ile Ser Gln Glu Thr Val His Thr 
                565                 570                 575     


Thr Arg Leu Tyr Gly Leu Ser Thr Phe Lys Asp Ala Arg His Ala Ala 
            580                 585                 590         


Glu Gly Glu Ile Tyr Thr Lys Leu Asn Gln Lys Ile Asp Glu Phe Val 
        595                 600                 605             


Gln Leu Ala Asp Tyr Asp Trp Thr Met Ser Glu Pro Asp Gly Arg Ala 
    610                 615                 620                 


Ser Gly Tyr Leu Met Asp Leu Ile Asn Phe Leu Arg Ser Ile Phe Gln 
625                 630                 635                 640 


Val Phe Thr His Leu Pro Gly Lys Val Ala Gln Thr Ala Cys Met Ser 
                645                 650                 655     


Ala Cys Gln His Leu Ser Thr Ser Leu Met Gln Met Leu Leu Asp Ser 
            660                 665                 670         


Glu Leu Lys Gln Ile Ser Met Gly Ala Val Gln Gln Phe Asn Leu Asp 
        675                 680                 685             


Val Ile Gln Cys Glu Leu Phe Ala Ser Ser Glu Pro Val Pro Gly Phe 
    690                 695                 700                 


Gln Gly Asp Thr Leu Gln Leu Ala Phe Ile Asp Leu Arg Gln Leu Leu 
705                 710                 715                 720 


Asp Leu Phe Met Val Trp Asp Trp Ser Thr Tyr Leu Ala Asp Tyr Gly 
                725                 730                 735     


Gln Pro Ala Ser Lys Tyr Leu Arg Val Asn Pro Asn Thr Ala Leu Thr 
            740                 745                 750         


Leu Leu Glu Lys Met Lys Asp Thr Ser Lys Lys Asn Asn Ile Phe Ala 
        755                 760                 765             


Gln Phe Arg Lys Asn Asp Arg Asp Lys Gln Lys Leu Ile Glu Thr Val 
    770                 775                 780                 


Val Lys Gln Leu Arg Ser Leu Val Asn Gly Met Ser Gln His Met 
785                 790                 795                 


<210>  2580
<211>  3606
<212>  DNA
<213>  Homosapiens

<400>  2580
gtcgttcccg cggcgccgcg cctcgctggc tcctcagctt ccagccaaaa tggcggagaa     60

cagcgagagt ctgggcaccg tccccgagca cgagcggatc ttgcaggaga tcgagagcac    120

cgacaccgcc tgtgtggggc ccaccctccg gtctgtgtat gatgaccaac caaatgcgca    180

caagaagttt atggaaaagt tagatgcttg tatccgtaat catgacaagg aaattgaaaa    240

gatgtgtaat tttcatcatc agggttttgt agatgctatt acagaactcc ttaaagtaag    300

gactgatgca gaaaaactga aggtgcaagt tactgatacc aaccgaaggt ttcaagatgc    360

tggaaaagag gtgatagtcc acacagaaga tatcattcga tgtagaattc agcagagaaa    420

tattacaact gtagtagaaa aattgcagtt atgccttcct gtgctagaaa tgtacagtaa    480

gctgaaagaa cagatgagtg ccaaaaggta ctattctgcc ctaaaaacta tggaacaatt    540

agagaatgtg tactttccct gggttagtca ataccggttt tgtcagctca tgatagaaaa    600

tcttcccaaa ctccgtgagg atattaaaga aatctccatg tctgatctca aagacttttt    660

ggaaagtatt cgaaaacatt ctgacaaaat aggtgaaaca gcaatgaaac aggcacagca    720

tcagaaaacc ttcagtgttt ctctgcagaa acaaaataaa atgaaatttg ggaaaaatat    780

gtatataaat cgtgatagaa ttccagagga aaggaatgaa actgtattga aacattcact    840

tgaagaagag gatgagaatg aagaagagat cttaactgtt caggatcttg ttgatttttc    900

ccctgtttat cgatgtttgc acatttattc tgttttgggt gacgaggaaa catttgaaaa    960

ctattatcga aaacaaagaa agaaacaagc aagactggta ttgcaacccc agtcgaatat   1020

gcatgaaaca gttgatggct atagaagata tttcactcaa attgtagggt tctttgtggt   1080

agaagatcac attttacatg tgacccaagg attagtaacc agggcataca ctgatgaact   1140

ttggaacatg gccctctcaa agataattgc tgtccttaga gctcattcat cctattgcac   1200

tgatcctgat cttgttctgg agctgaagaa tcttactgta atatttgcag atactttaca   1260

gggttatggt tttccagtga accgactttt tgacctttta tttgaaataa gagaccaata   1320

caatgaaaca ctgcttaaga aatgggctgg agttttcagg gacatttttg aagaagataa   1380

ttacagcccc atccctgttg tcaatgaaga agaatataaa attgtcatca gcaaatttcc   1440

ctttcaagat ccagaccttg aaaagcagtc tttcccaaag aaattcccca tgtctcagtc   1500

agtgcctcat atttacattc aagttaaaga atttatttat gccagcctta aattttcaga   1560

gtcactacac cggagctcaa cagaaataga cgatatgctt agaaaatcaa caaatctgct   1620

gctgaccaga actttgagta gctgtttact gaaccttatt agaaaacctc atataggttt   1680

gacagagctg gtacaaatca tcataaacac aacacacctg gagcaagctt gtaaatatct   1740

tgaggacttt ataactaaca ttacaaatat ttcccaagaa actgttcata ctacaagact   1800

ttatggactt tctactttca aggatgctcg acatgcagca gaaggagaaa tatataccaa   1860

actgaatcaa aaaattgatg aatttgttca gcttgctgat tatgactgga caatgtctga   1920

gccagatgga agagctagtg gttatttaat ggaccttata aattttttga gaagcatctt   1980

tcaagtgttt actcatttgc ctgggaaagt tgctcagaca gcttgcatgt cagcctgcca   2040

gcatctgtca acatccttaa tgcagatgct actggacagt gagttaaaac aaataagcat   2100

gggagctgtt cagcagttta acttagatgt catacagtgt gaattgtttg ccagctctga   2160

gcctgtgcca ggattccagg gggataccct gcagctagca ttcattgacc tcagacaact   2220

ccttgacctg tttatggttt gggattggtc tacttaccta gctgattatg ggcagccagc   2280

ttctaagtac cttcgggtga atccaaacac agcccttact cttttggaga agatgaagga   2340

tactagcaaa aagaacaata tatttgctca gttcaggaag aatgatcgag acaaacagaa   2400

gttgatagag acagtcgtga aacagctgag aagtttggtg aatggtatgt cccagcacat   2460

gtagacctca catggcttgc actcagtgac accaaatcca tgattcaatg ttgatcttga   2520

gcaagtattg gtcatgatac agtaatttgt ttacagaatc caaaaataca atagagaaga   2580

tacatgaggg cttaaacaag aaatagtaat aaatatcatt tgtatggatt tttaaataat   2640

cgaatactat tttatatatg gaaaaaaatg accatttttt cacttttagg ggaaaatgca   2700

aaagtgtaat acataaattg tcacaaatta tacctgaaat tgattacaaa tacatttgaa   2760

aaacatatgc ctctactcat aagtattttt ttctatttag acttgaatga taatctgttt   2820

tttgatcagt atatggcttt ggaattcaat catgtctgat atggtagtat ttcactacca   2880

ttttctgact tttagctttt attttcacct caatgtgatt taagcagacc aaaatttcta   2940

attctgctaa ttctgaaggg gaaatagaca aatcttaaaa gctgcctgaa atcaaacttg   3000

atttaactca gtaagaatgt gaattatttg ttctacttgg gtggtttaat ttaatcgttc   3060

tgaatatgaa caaaaggttt tggattttct aaagatgcag tgttgtttct gttcatcagg   3120

gttaatattt ctaactatat tgcttgtagg tgaccccatt ctggatttgt ttggtttggt   3180

ttggttccag ttaaaagaga ggacaggaac taaatggggc taaccacttc aggtgcagct   3240

tgtgcgaggg tagatggttc ctgcacacag aagttaccac aggggtcagg ttactttctt   3300

caaatagcag atttcagtac tttatcctca ttgtggaaac aagccaaacc aaatgaactc   3360

tggaaaacct aaaacaaatg tacattttcc tttgtgtatg tttccgtggt ccaaatggca   3420

atataaatcc agtctttatt ctccctttgt tgtatttatg ctgaatcttc cctttgcctt   3480

ttcaggattt aggcctgtaa gaaactatgc ctgattctgt aaaataagtg taaagaatta   3540

tatgtacatc tctggatttt gtgatgaaat attaaaaata ttgagcaagt tgttgaaaat   3600

gcaaaa                                                              3606


<210>  2581
<211>  804
<212>  PRT
<213>  Homosapiens

<400>  2581

Met Ala Glu Asn Ser Glu Ser Leu Gly Thr Val Pro Glu His Glu Arg 
1               5                   10                  15      


Ile Leu Gln Glu Ile Glu Ser Thr Asp Thr Ala Cys Val Gly Pro Thr 
            20                  25                  30          


Leu Arg Ser Val Tyr Asp Asp Gln Pro Asn Ala His Lys Lys Phe Met 
        35                  40                  45              


Glu Lys Leu Asp Ala Cys Ile Arg Asn His Asp Lys Glu Ile Glu Lys 
    50                  55                  60                  


Met Cys Asn Phe His His Gln Gly Phe Val Asp Ala Ile Thr Glu Leu 
65                  70                  75                  80  


Leu Lys Val Arg Thr Asp Ala Glu Lys Leu Lys Val Gln Val Thr Asp 
                85                  90                  95      


Thr Asn Arg Arg Phe Gln Asp Ala Gly Lys Glu Val Ile Val His Thr 
            100                 105                 110         


Glu Asp Ile Ile Arg Cys Arg Ile Gln Gln Arg Asn Ile Thr Thr Val 
        115                 120                 125             


Val Glu Lys Leu Gln Leu Cys Leu Pro Val Leu Glu Met Tyr Ser Lys 
    130                 135                 140                 


Leu Lys Glu Gln Met Ser Ala Lys Arg Tyr Tyr Ser Ala Leu Lys Thr 
145                 150                 155                 160 


Met Glu Gln Leu Glu Asn Val Tyr Phe Pro Trp Val Ser Gln Tyr Arg 
                165                 170                 175     


Phe Cys Gln Leu Met Ile Glu Asn Leu Pro Lys Leu Arg Glu Asp Ile 
            180                 185                 190         


Lys Glu Ile Ser Met Ser Asp Leu Lys Asp Phe Leu Glu Ser Ile Arg 
        195                 200                 205             


Lys His Ser Asp Lys Ile Gly Glu Thr Ala Met Lys Gln Ala Gln His 
    210                 215                 220                 


Gln Lys Thr Phe Ser Val Ser Leu Gln Lys Gln Asn Lys Met Lys Phe 
225                 230                 235                 240 


Gly Lys Asn Met Tyr Ile Asn Arg Asp Arg Ile Pro Glu Glu Arg Asn 
                245                 250                 255     


Glu Thr Val Leu Lys His Ser Leu Glu Glu Glu Asp Glu Asn Glu Glu 
            260                 265                 270         


Glu Ile Leu Thr Val Gln Asp Leu Val Asp Phe Ser Pro Val Tyr Arg 
        275                 280                 285             


Cys Leu His Ile Tyr Ser Val Leu Gly Asp Glu Glu Thr Phe Glu Asn 
    290                 295                 300                 


Tyr Tyr Arg Lys Gln Arg Lys Lys Gln Ala Arg Leu Val Leu Gln Pro 
305                 310                 315                 320 


Gln Ser Asn Met His Glu Thr Val Asp Gly Tyr Arg Arg Tyr Phe Thr 
                325                 330                 335     


Gln Ile Val Gly Phe Phe Val Val Glu Asp His Ile Leu His Val Thr 
            340                 345                 350         


Gln Gly Leu Val Thr Arg Ala Tyr Thr Asp Glu Leu Trp Asn Met Ala 
        355                 360                 365             


Leu Ser Lys Ile Ile Ala Val Leu Arg Ala His Ser Ser Tyr Cys Thr 
    370                 375                 380                 


Asp Pro Asp Leu Val Leu Glu Leu Lys Asn Leu Thr Val Ile Phe Ala 
385                 390                 395                 400 


Asp Thr Leu Gln Gly Tyr Gly Phe Pro Val Asn Arg Leu Phe Asp Leu 
                405                 410                 415     


Leu Phe Glu Ile Arg Asp Gln Tyr Asn Glu Thr Leu Leu Lys Lys Trp 
            420                 425                 430         


Ala Gly Val Phe Arg Asp Ile Phe Glu Glu Asp Asn Tyr Ser Pro Ile 
        435                 440                 445             


Pro Val Val Asn Glu Glu Glu Tyr Lys Ile Val Ile Ser Lys Phe Pro 
    450                 455                 460                 


Phe Gln Asp Pro Asp Leu Glu Lys Gln Ser Phe Pro Lys Lys Phe Pro 
465                 470                 475                 480 


Met Ser Gln Ser Val Pro His Ile Tyr Ile Gln Val Lys Glu Phe Ile 
                485                 490                 495     


Tyr Ala Ser Leu Lys Phe Ser Glu Ser Leu His Arg Ser Ser Thr Glu 
            500                 505                 510         


Ile Asp Asp Met Leu Arg Lys Ser Thr Asn Leu Leu Leu Thr Arg Thr 
        515                 520                 525             


Leu Ser Ser Cys Leu Leu Asn Leu Ile Arg Lys Pro His Ile Gly Leu 
    530                 535                 540                 


Thr Glu Leu Val Gln Ile Ile Ile Asn Thr Thr His Leu Glu Gln Ala 
545                 550                 555                 560 


Cys Lys Tyr Leu Glu Asp Phe Ile Thr Asn Ile Thr Asn Ile Ser Gln 
                565                 570                 575     


Glu Thr Val His Thr Thr Arg Leu Tyr Gly Leu Ser Thr Phe Lys Asp 
            580                 585                 590         


Ala Arg His Ala Ala Glu Gly Glu Ile Tyr Thr Lys Leu Asn Gln Lys 
        595                 600                 605             


Ile Asp Glu Phe Val Gln Leu Ala Asp Tyr Asp Trp Thr Met Ser Glu 
    610                 615                 620                 


Pro Asp Gly Arg Ala Ser Gly Tyr Leu Met Asp Leu Ile Asn Phe Leu 
625                 630                 635                 640 


Arg Ser Ile Phe Gln Val Phe Thr His Leu Pro Gly Lys Val Ala Gln 
                645                 650                 655     


Thr Ala Cys Met Ser Ala Cys Gln His Leu Ser Thr Ser Leu Met Gln 
            660                 665                 670         


Met Leu Leu Asp Ser Glu Leu Lys Gln Ile Ser Met Gly Ala Val Gln 
        675                 680                 685             


Gln Phe Asn Leu Asp Val Ile Gln Cys Glu Leu Phe Ala Ser Ser Glu 
    690                 695                 700                 


Pro Val Pro Gly Phe Gln Gly Asp Thr Leu Gln Leu Ala Phe Ile Asp 
705                 710                 715                 720 


Leu Arg Gln Leu Leu Asp Leu Phe Met Val Trp Asp Trp Ser Thr Tyr 
                725                 730                 735     


Leu Ala Asp Tyr Gly Gln Pro Ala Ser Lys Tyr Leu Arg Val Asn Pro 
            740                 745                 750         


Asn Thr Ala Leu Thr Leu Leu Glu Lys Met Lys Asp Thr Ser Lys Lys 
        755                 760                 765             


Asn Asn Ile Phe Ala Gln Phe Arg Lys Asn Asp Arg Asp Lys Gln Lys 
    770                 775                 780                 


Leu Ile Glu Thr Val Val Lys Gln Leu Arg Ser Leu Val Asn Gly Met 
785                 790                 795                 800 


Ser Gln His Met 
                


<210>  2582
<211>  3997
<212>  DNA
<213>  Homosapiens

<400>  2582
gtgccaaggc ggctgggggc ggcgagcggg gccgcgggcg cgcaccgact caagagccga     60

ctgtcagcct cggcgggccg gagttctccg gcgctgggac aggggcgctg ggacaggggc    120

gctgggggcg agccctggcg ggggccaggt ccgaggaccc tgggcgcggc ggccccgcca    180

ggaggtccgg ccgcgagcgt gacctcacgg ggaggggcca gcgcggcggc ctgggcgctg    240

agccgagcgc cgggagagca gcgcagaagc cgagccgcga ggagcgcact ccgtggcccc    300

gatggagcgg tacaaagccc tggaacagct gctgacagag ttggatgact tcctcaagat    360

tcttgaccag gagaacctga gcagcacagc actggtgaag aagagctgcc tggcggagct    420

cctccggctt tacaccaaaa gcagcagctc tgatgaggag tacatttata tgaacaaagt    480

gaccatcaac aagcaacaga atgcagagtc tcaaggcaaa gcgcctgagg agcagggcct    540

gctacccaat ggggagccca gccagcactc ctcggcccct cagaagagcc ttccagacct    600

cccgccaccc aagatgattc cagaacggaa acagcttgcc atcccaaaga cggagtctcc    660

agagggctac tatgaagagg ctgagccata tgacacatcc ctcaatgagg acggagaggc    720

tgtgagcagc tcctacgagt cctacgatga agaggacggc agcaagggca agtcggcccc    780

ttaccagtgg ccctcgccgg aggccggcat cgagctgatg cgtgacgccc gcatctgcgc    840

cttcctgtgg cgcaagaagt ggctgggaca gtgggccaag cagctctgtg tcatcaagga    900

caacaggctt ctgtgctaca aatcctccaa ggaccacagc cctcagctgg acgtgaacct    960

actgggcagc agcgtcattc acaaggagaa gcaagtgcgg aagaaggagc acaagctgaa   1020

gatcacaccg atgaatgccg atgtgattgt gctgggcctg cagagcaagg accaggctga   1080

gcagtggctc agggtcatcc aggaagtgag cggcctgcct tccgaaggag catctgaagg   1140

aaaccagtac accccggatg cccagcgctt taactgccag aaaccagata tagctgagaa   1200

gtacctgtcg gcttcagagt atgggagctc cgtggatggc caccctgagg tcccagaaac   1260

caaagacgtc aagaagaaat gttctgctgg cctcaaactg agcaacctaa tgaatctggg   1320

caggaagaaa tccacctcac tggagcctgt ggagaggtcc ctcgagacat ccagttacct   1380

gaacgtgctg gtgaacagcc agtggaagtc tcgctggtgc tctgtcaggg acaatcacct   1440

gcacttctac caggaccgga accggagcaa ggtggcccag caacccctca gcctggtggg   1500

ctgcgaggtg gtcccagacc ccagccccga ccacctctac tccttccgca tcctccacaa   1560

gggcgaggag ctggccaagc ttgaggccaa gtcttccgag gaaatgggcc actggctggg   1620

tctcctgctc tctgagtcag gctccaagac agacccagaa gagttcacct acgactatgt   1680

ggatgccgat agggtctcct gtattgtgag tgcggccaaa aactctctct tactgatgca   1740

gagaaagttc tcagagccca acacttacat cgatggcctg cctagccagg accgccagga   1800

ggagctgtat gacgacgtgg acctgtcaga gctcacagct gcggtggagc ctaccgagga   1860

agccacccct gttgcagatg acccaaatga gagagaatct gaccgagtgt acctggacct   1920

cacacctgtc aagtcctttc tgcatggccc cagcagtgca caggcccagg cctcctcccc   1980

gacgttgtcc tgcctggaca atgcaactga ggccctcccg gcagactcag gcccaggtcc   2040

caccccagat gagccctgca taaagtgtcc agagaacctg ggagaacagc agctggagag   2100

tttggagcca gaggatcctt ccctgagaat caccaccgtc aaaatccaga cggaacagca   2160

gagaatctcc ttcccaccga gctgcccgga tgccgtggtg gccaccccac ctggtgccag   2220

cccacctgtg aaggacaggt tgcgcgtgac cagtgcagag atcaagcttg gcaagaatcg   2280

gacagaagct gaggtgaagc ggtacacaga ggagaaggag aggcttgaaa agaagaagga   2340

agaaatccgg gggcacctgg ctcagctccg gaaagagaaa cgggagctaa aggaaaccct   2400

actgaaatgc acagacaagg aagtcctggc gagcctggag cagaagctga aggaaattga   2460

cgaggagtgc cggggcgagg agagcaggcg cgtggacctg gagctcagca tcatggaggt   2520

gaaggacaac ctgaagaagg ctgaggcagg gcctgtgacg ttaggcacca ccgtggacac   2580

cacccacctg gagaatgtga gcccccgccc caaagctgtc acacctgcct ctgccccaga   2640

ctgtacccca gtcaactctg caaccacact caagaacagg cctctctcgg tcgtggtcac   2700

aggcaaaggc actgtactcc agaaagccaa ggaatgggag aagaaaggag caagttagaa   2760

aacaagcttc atctaaagac tctcatgtca atgtggacct tggtgacaat cctgctttgt   2820

taaagcaaaa actatgcgaa agggtgagtc tgtttagaag aaaaagcaaa gactgaggta   2880

ctgtgaatgg agagcttcag ctaagaggag gctctgtccc ttttcagagc caaaggaaat   2940

aatacaacaa aaaggaggct tctttggaga cctaagtcta ttggatgtaa acaagacgtt   3000

gtatttaggg atgttctgtg tttctttctt ttttgaagtt gtcatcaatt gctttactaa   3060

gatttttaaa tagtgaaaac ctcctgttta gactttggtg gaagatgaat caaggaagca   3120

gggccctgtc ttatgggtca cgtgtctttg gtgagtgaga agacctaaac tcctggccat   3180

catctcttat ccaatactta gcagttgggg attaaaccat ccttgccttc agttctctcc   3240

aatattacca ggcccaactc agtcttcagt gattttaaac agcattgaca tcatctgtaa   3300

aaccatcatc tgtaaaacca tctatgacat gagttttgag aaacaataat ggggaaaata   3360

tttgggacca agctgaagca ctaatcccac taagttaaag acttctttcc agtccaaggc   3420

aggcctgaat caactgtctt taaataaaat tttaagtgat gctgtattat atataggaaa   3480

aaatgcttaa aatcctgtca tttagaacag tgaaaagtat cttttgagat taaagtgact   3540

ctttactgta ggaaaaatat tactctgtgt ttacagattc attgctgtgg tcaggccatt   3600

tttaagggaa gagttattta atataaatag tctctgattt taagttctgt ttaatgttca   3660

ttctccttcc aagaacaaag tggtgatttt tggttagggt gatcgccctc ttaaaattgg   3720

cagtgctgtt ccttgtgctg cccctgtctt ttcctctgat ggcatttttt tttttttttt   3780

tttaacacag gttgaaacat ttcatctatt atctctgcct catttctgga gggttgtgta   3840

tcagttctct aacacttgtt cctgagaact aaatgtcttt tttattctta tttcctctct   3900

cataaacatt tggtgacctt ttaccaagtg gtgagttagt taggtttttt aaaataaaat   3960

gttcattgta tttgaaaaaa aaaaaaaaaa aaaaaaa                            3997


<210>  2583
<211>  818
<212>  PRT
<213>  Homosapiens

<400>  2583

Met Glu Arg Tyr Lys Ala Leu Glu Gln Leu Leu Thr Glu Leu Asp Asp 
1               5                   10                  15      


Phe Leu Lys Ile Leu Asp Gln Glu Asn Leu Ser Ser Thr Ala Leu Val 
            20                  25                  30          


Lys Lys Ser Cys Leu Ala Glu Leu Leu Arg Leu Tyr Thr Lys Ser Ser 
        35                  40                  45              


Ser Ser Asp Glu Glu Tyr Ile Tyr Met Asn Lys Val Thr Ile Asn Lys 
    50                  55                  60                  


Gln Gln Asn Ala Glu Ser Gln Gly Lys Ala Pro Glu Glu Gln Gly Leu 
65                  70                  75                  80  


Leu Pro Asn Gly Glu Pro Ser Gln His Ser Ser Ala Pro Gln Lys Ser 
                85                  90                  95      


Leu Pro Asp Leu Pro Pro Pro Lys Met Ile Pro Glu Arg Lys Gln Leu 
            100                 105                 110         


Ala Ile Pro Lys Thr Glu Ser Pro Glu Gly Tyr Tyr Glu Glu Ala Glu 
        115                 120                 125             


Pro Tyr Asp Thr Ser Leu Asn Glu Asp Gly Glu Ala Val Ser Ser Ser 
    130                 135                 140                 


Tyr Glu Ser Tyr Asp Glu Glu Asp Gly Ser Lys Gly Lys Ser Ala Pro 
145                 150                 155                 160 


Tyr Gln Trp Pro Ser Pro Glu Ala Gly Ile Glu Leu Met Arg Asp Ala 
                165                 170                 175     


Arg Ile Cys Ala Phe Leu Trp Arg Lys Lys Trp Leu Gly Gln Trp Ala 
            180                 185                 190         


Lys Gln Leu Cys Val Ile Lys Asp Asn Arg Leu Leu Cys Tyr Lys Ser 
        195                 200                 205             


Ser Lys Asp His Ser Pro Gln Leu Asp Val Asn Leu Leu Gly Ser Ser 
    210                 215                 220                 


Val Ile His Lys Glu Lys Gln Val Arg Lys Lys Glu His Lys Leu Lys 
225                 230                 235                 240 


Ile Thr Pro Met Asn Ala Asp Val Ile Val Leu Gly Leu Gln Ser Lys 
                245                 250                 255     


Asp Gln Ala Glu Gln Trp Leu Arg Val Ile Gln Glu Val Ser Gly Leu 
            260                 265                 270         


Pro Ser Glu Gly Ala Ser Glu Gly Asn Gln Tyr Thr Pro Asp Ala Gln 
        275                 280                 285             


Arg Phe Asn Cys Gln Lys Pro Asp Ile Ala Glu Lys Tyr Leu Ser Ala 
    290                 295                 300                 


Ser Glu Tyr Gly Ser Ser Val Asp Gly His Pro Glu Val Pro Glu Thr 
305                 310                 315                 320 


Lys Asp Val Lys Lys Lys Cys Ser Ala Gly Leu Lys Leu Ser Asn Leu 
                325                 330                 335     


Met Asn Leu Gly Arg Lys Lys Ser Thr Ser Leu Glu Pro Val Glu Arg 
            340                 345                 350         


Ser Leu Glu Thr Ser Ser Tyr Leu Asn Val Leu Val Asn Ser Gln Trp 
        355                 360                 365             


Lys Ser Arg Trp Cys Ser Val Arg Asp Asn His Leu His Phe Tyr Gln 
    370                 375                 380                 


Asp Arg Asn Arg Ser Lys Val Ala Gln Gln Pro Leu Ser Leu Val Gly 
385                 390                 395                 400 


Cys Glu Val Val Pro Asp Pro Ser Pro Asp His Leu Tyr Ser Phe Arg 
                405                 410                 415     


Ile Leu His Lys Gly Glu Glu Leu Ala Lys Leu Glu Ala Lys Ser Ser 
            420                 425                 430         


Glu Glu Met Gly His Trp Leu Gly Leu Leu Leu Ser Glu Ser Gly Ser 
        435                 440                 445             


Lys Thr Asp Pro Glu Glu Phe Thr Tyr Asp Tyr Val Asp Ala Asp Arg 
    450                 455                 460                 


Val Ser Cys Ile Val Ser Ala Ala Lys Asn Ser Leu Leu Leu Met Gln 
465                 470                 475                 480 


Arg Lys Phe Ser Glu Pro Asn Thr Tyr Ile Asp Gly Leu Pro Ser Gln 
                485                 490                 495     


Asp Arg Gln Glu Glu Leu Tyr Asp Asp Val Asp Leu Ser Glu Leu Thr 
            500                 505                 510         


Ala Ala Val Glu Pro Thr Glu Glu Ala Thr Pro Val Ala Asp Asp Pro 
        515                 520                 525             


Asn Glu Arg Glu Ser Asp Arg Val Tyr Leu Asp Leu Thr Pro Val Lys 
    530                 535                 540                 


Ser Phe Leu His Gly Pro Ser Ser Ala Gln Ala Gln Ala Ser Ser Pro 
545                 550                 555                 560 


Thr Leu Ser Cys Leu Asp Asn Ala Thr Glu Ala Leu Pro Ala Asp Ser 
                565                 570                 575     


Gly Pro Gly Pro Thr Pro Asp Glu Pro Cys Ile Lys Cys Pro Glu Asn 
            580                 585                 590         


Leu Gly Glu Gln Gln Leu Glu Ser Leu Glu Pro Glu Asp Pro Ser Leu 
        595                 600                 605             


Arg Ile Thr Thr Val Lys Ile Gln Thr Glu Gln Gln Arg Ile Ser Phe 
    610                 615                 620                 


Pro Pro Ser Cys Pro Asp Ala Val Val Ala Thr Pro Pro Gly Ala Ser 
625                 630                 635                 640 


Pro Pro Val Lys Asp Arg Leu Arg Val Thr Ser Ala Glu Ile Lys Leu 
                645                 650                 655     


Gly Lys Asn Arg Thr Glu Ala Glu Val Lys Arg Tyr Thr Glu Glu Lys 
            660                 665                 670         


Glu Arg Leu Glu Lys Lys Lys Glu Glu Ile Arg Gly His Leu Ala Gln 
        675                 680                 685             


Leu Arg Lys Glu Lys Arg Glu Leu Lys Glu Thr Leu Leu Lys Cys Thr 
    690                 695                 700                 


Asp Lys Glu Val Leu Ala Ser Leu Glu Gln Lys Leu Lys Glu Ile Asp 
705                 710                 715                 720 


Glu Glu Cys Arg Gly Glu Glu Ser Arg Arg Val Asp Leu Glu Leu Ser 
                725                 730                 735     


Ile Met Glu Val Lys Asp Asn Leu Lys Lys Ala Glu Ala Gly Pro Val 
            740                 745                 750         


Thr Leu Gly Thr Thr Val Asp Thr Thr His Leu Glu Asn Val Ser Pro 
        755                 760                 765             


Arg Pro Lys Ala Val Thr Pro Ala Ser Ala Pro Asp Cys Thr Pro Val 
    770                 775                 780                 


Asn Ser Ala Thr Thr Leu Lys Asn Arg Pro Leu Ser Val Val Val Thr 
785                 790                 795                 800 


Gly Lys Gly Thr Val Leu Gln Lys Ala Lys Glu Trp Glu Lys Lys Gly 
                805                 810                 815     


Ala Ser 
        


<210>  2584
<211>  3985
<212>  DNA
<213>  Homosapiens

<400>  2584
gtgccaaggc ggctgggggc ggcgagcggg gccgcgggcg cgcaccgact caagagccga     60

ctgtcagcct cggcgggccg gagttctccg gcgctgggac aggggcgctg ggacaggggc    120

gctgggggcg agccctggcg ggggccaggt ccgaggaccc tgggcgcggc ggccccgcca    180

ggaggtccgg ccgcgagcgt gacctcacgg ggaggggcca gcgcggcggc ctgggcgctg    240

agccgagcgc cgggagagca gcgcagaagc cgagccgcga ggagcgcact ccgtggcccc    300

gatggagcgg tacaaagccc tggaacagct gctgacagag ttggatgact tcctcaagat    360

tcttgaccag gagaacctga gcagcacagc actggtgaag aagagctgcc tggcggagct    420

cctccggctt tacaccaaaa gcagcagctc tgatgaggag tacatttata tgaacaaagt    480

gaccatcaac aagcaacaga atgcagagtc tcaaggcaaa gcgcctgagg agcagggcct    540

gctacccaat ggggagccca gccagcactc ctcggcccct cagaagagcc ttccagacct    600

cccgccaccc aagatgattc cagaacggaa acagcttgcc atcccaaaga cggagtctcc    660

agagggctac tatgaagagg ctgagccata tgacacatcc ctcaatgagg acggagaggc    720

tgtgagcagc tcctacgagt cctacgatga agaggacggc agcaagggca agtcggcccc    780

ttaccagtgg ccctcgccgg aggccggcat cgagctgatg cgtgacgccc gcatctgcgc    840

cttcctgtgg cgcaagaagt ggctgggaca gtgggccaag cagctctgtg tcatcaagga    900

caacaggctt ctgtgctaca aatcctccaa ggaccacagc cctcagctgg acgtgaacct    960

actgggcagc agcgtcattc acaaggagaa gcaagtgcgg aagaaggagc acaagctgaa   1020

gatcacaccg atgaatgccg atgtgattgt gctgggcctg cagagcaagg accaggctga   1080

gcagtggctc agggtcatcc aggaagtgag cggcctgcct tccgaaggag catctgaagg   1140

aaaccagtac accccggatg cccagcgctt taactgccag aaaccagata tagctgagaa   1200

gtacctgtcg gcttcagagt atgggagctc cgtggatggc caccctgagg tcccagaaac   1260

caaagacgtc aagaagaaat gttctgctgg cctcaaactg agcaacctaa tgaatctggg   1320

caggaagaaa tccacctcac tggagcctgt ggagaggtcc ctcgagacat ccagttacct   1380

gaacgtgctg gtgaacagcc agtggaagtc tcgctggtgc tctgtcaggg acaatcacct   1440

gcacttctac caggaccgga accggagcaa ggtggcccag caacccctca gcctggtggg   1500

ctgcgaggtg gtcccagacc ccagccccga ccacctctac tccttccgca tcctccacaa   1560

gggcgaggag ctggccaagc ttgaggccaa gtcttccgag gaaatgggcc actggctggg   1620

tctcctgctc tctgagtcag gctccaagac agacccagaa gagttcacct acgactatgt   1680

ggatgccgat agggtctcct gtattgtgag tgcggccaaa aactctctct tactgatgca   1740

gagaaagttc tcagagccca acacttacat cgatggcctg cctagccagg accgccagga   1800

ggagctgtat gacgacgtgg acctgtcaga gctcacagct gcggtggagc ctaccgagga   1860

agccacccct gttgcagatg acccaaatga gagagaatct gaccgagtgt acctggacct   1920

cacacctgtc aagtcctttc tgcatggccc cagcagtgca caggcccagg cctcctcccc   1980

gacgttgtcc tgcctggaca atgcaactga ggccctcccg gcagactcag gcccaggtcc   2040

caccccagat gagccctgca taaagtgtcc agagaacctg ggagaacagc agctggagag   2100

tttggagcca gaggatcctt ccctgagaat caccaccgtc aaaatccaga cggaacagca   2160

gagaatctcc ttcccaccga gctgcccgga tgccgtggtg gccaccccac ctggtgccag   2220

cccacctgtg aaggacaggt tgcgcgtgac cagtgcagag atcaagcttg gcaagaatcg   2280

gacagaagct gaggtgaagc ggtacacaga ggagaaggag aggcttgaaa agaagaagga   2340

agaaatccgg gggcacctgg ctcagctccg gaaagagaaa cgggagctaa aggaaaccct   2400

actgaaatgc acagacaagg aagtcctggc gagcctggag cagaagctga aggaaattga   2460

cgaggagtgc cggggcgagg agagcaggcg cgtggacctg gagctcagca tcatggaggt   2520

gaaggacaac ctgaagaagg ctgaggcagg gcctgtgacg ttaggcacca ccgtggacac   2580

cacccacctg gagaatccca aagctgtcac acctgcctct gccccagact gtaccccagt   2640

caactctgca accacactca agaacaggcc tctctcggtc gtggtcacag gcaaaggcac   2700

tgtactccag aaagccaagg aatgggagaa gaaaggagca agttagaaaa caagcttcat   2760

ctaaagactc tcatgtcaat gtggaccttg gtgacaatcc tgctttgtta aagcaaaaac   2820

tatgcgaaag ggtgagtctg tttagaagaa aaagcaaaga ctgaggtact gtgaatggag   2880

agcttcagct aagaggaggc tctgtccctt ttcagagcca aaggaaataa tacaacaaaa   2940

aggaggcttc tttggagacc taagtctatt ggatgtaaac aagacgttgt atttagggat   3000

gttctgtgtt tctttctttt ttgaagttgt catcaattgc tttactaaga tttttaaata   3060

gtgaaaacct cctgtttaga ctttggtgga agatgaatca aggaagcagg gccctgtctt   3120

atgggtcacg tgtctttggt gagtgagaag acctaaactc ctggccatca tctcttatcc   3180

aatacttagc agttggggat taaaccatcc ttgccttcag ttctctccaa tattaccagg   3240

cccaactcag tcttcagtga ttttaaacag cattgacatc atctgtaaaa ccatcatctg   3300

taaaaccatc tatgacatga gttttgagaa acaataatgg ggaaaatatt tgggaccaag   3360

ctgaagcact aatcccacta agttaaagac ttctttccag tccaaggcag gcctgaatca   3420

actgtcttta aataaaattt taagtgatgc tgtattatat ataggaaaaa atgcttaaaa   3480

tcctgtcatt tagaacagtg aaaagtatct tttgagatta aagtgactct ttactgtagg   3540

aaaaatatta ctctgtgttt acagattcat tgctgtggtc aggccatttt taagggaaga   3600

gttatttaat ataaatagtc tctgatttta agttctgttt aatgttcatt ctccttccaa   3660

gaacaaagtg gtgatttttg gttagggtga tcgccctctt aaaattggca gtgctgttcc   3720

ttgtgctgcc cctgtctttt cctctgatgg catttttttt tttttttttt taacacaggt   3780

tgaaacattt catctattat ctctgcctca tttctggagg gttgtgtatc agttctctaa   3840

cacttgttcc tgagaactaa atgtcttttt tattcttatt tcctctctca taaacatttg   3900

gtgacctttt accaagtggt gagttagtta ggttttttaa aataaaatgt tcattgtatt   3960

tgaaaaaaaa aaaaaaaaaa aaaaa                                         3985


<210>  2585
<211>  814
<212>  PRT
<213>  Homosapiens

<400>  2585

Met Glu Arg Tyr Lys Ala Leu Glu Gln Leu Leu Thr Glu Leu Asp Asp 
1               5                   10                  15      


Phe Leu Lys Ile Leu Asp Gln Glu Asn Leu Ser Ser Thr Ala Leu Val 
            20                  25                  30          


Lys Lys Ser Cys Leu Ala Glu Leu Leu Arg Leu Tyr Thr Lys Ser Ser 
        35                  40                  45              


Ser Ser Asp Glu Glu Tyr Ile Tyr Met Asn Lys Val Thr Ile Asn Lys 
    50                  55                  60                  


Gln Gln Asn Ala Glu Ser Gln Gly Lys Ala Pro Glu Glu Gln Gly Leu 
65                  70                  75                  80  


Leu Pro Asn Gly Glu Pro Ser Gln His Ser Ser Ala Pro Gln Lys Ser 
                85                  90                  95      


Leu Pro Asp Leu Pro Pro Pro Lys Met Ile Pro Glu Arg Lys Gln Leu 
            100                 105                 110         


Ala Ile Pro Lys Thr Glu Ser Pro Glu Gly Tyr Tyr Glu Glu Ala Glu 
        115                 120                 125             


Pro Tyr Asp Thr Ser Leu Asn Glu Asp Gly Glu Ala Val Ser Ser Ser 
    130                 135                 140                 


Tyr Glu Ser Tyr Asp Glu Glu Asp Gly Ser Lys Gly Lys Ser Ala Pro 
145                 150                 155                 160 


Tyr Gln Trp Pro Ser Pro Glu Ala Gly Ile Glu Leu Met Arg Asp Ala 
                165                 170                 175     


Arg Ile Cys Ala Phe Leu Trp Arg Lys Lys Trp Leu Gly Gln Trp Ala 
            180                 185                 190         


Lys Gln Leu Cys Val Ile Lys Asp Asn Arg Leu Leu Cys Tyr Lys Ser 
        195                 200                 205             


Ser Lys Asp His Ser Pro Gln Leu Asp Val Asn Leu Leu Gly Ser Ser 
    210                 215                 220                 


Val Ile His Lys Glu Lys Gln Val Arg Lys Lys Glu His Lys Leu Lys 
225                 230                 235                 240 


Ile Thr Pro Met Asn Ala Asp Val Ile Val Leu Gly Leu Gln Ser Lys 
                245                 250                 255     


Asp Gln Ala Glu Gln Trp Leu Arg Val Ile Gln Glu Val Ser Gly Leu 
            260                 265                 270         


Pro Ser Glu Gly Ala Ser Glu Gly Asn Gln Tyr Thr Pro Asp Ala Gln 
        275                 280                 285             


Arg Phe Asn Cys Gln Lys Pro Asp Ile Ala Glu Lys Tyr Leu Ser Ala 
    290                 295                 300                 


Ser Glu Tyr Gly Ser Ser Val Asp Gly His Pro Glu Val Pro Glu Thr 
305                 310                 315                 320 


Lys Asp Val Lys Lys Lys Cys Ser Ala Gly Leu Lys Leu Ser Asn Leu 
                325                 330                 335     


Met Asn Leu Gly Arg Lys Lys Ser Thr Ser Leu Glu Pro Val Glu Arg 
            340                 345                 350         


Ser Leu Glu Thr Ser Ser Tyr Leu Asn Val Leu Val Asn Ser Gln Trp 
        355                 360                 365             


Lys Ser Arg Trp Cys Ser Val Arg Asp Asn His Leu His Phe Tyr Gln 
    370                 375                 380                 


Asp Arg Asn Arg Ser Lys Val Ala Gln Gln Pro Leu Ser Leu Val Gly 
385                 390                 395                 400 


Cys Glu Val Val Pro Asp Pro Ser Pro Asp His Leu Tyr Ser Phe Arg 
                405                 410                 415     


Ile Leu His Lys Gly Glu Glu Leu Ala Lys Leu Glu Ala Lys Ser Ser 
            420                 425                 430         


Glu Glu Met Gly His Trp Leu Gly Leu Leu Leu Ser Glu Ser Gly Ser 
        435                 440                 445             


Lys Thr Asp Pro Glu Glu Phe Thr Tyr Asp Tyr Val Asp Ala Asp Arg 
    450                 455                 460                 


Val Ser Cys Ile Val Ser Ala Ala Lys Asn Ser Leu Leu Leu Met Gln 
465                 470                 475                 480 


Arg Lys Phe Ser Glu Pro Asn Thr Tyr Ile Asp Gly Leu Pro Ser Gln 
                485                 490                 495     


Asp Arg Gln Glu Glu Leu Tyr Asp Asp Val Asp Leu Ser Glu Leu Thr 
            500                 505                 510         


Ala Ala Val Glu Pro Thr Glu Glu Ala Thr Pro Val Ala Asp Asp Pro 
        515                 520                 525             


Asn Glu Arg Glu Ser Asp Arg Val Tyr Leu Asp Leu Thr Pro Val Lys 
    530                 535                 540                 


Ser Phe Leu His Gly Pro Ser Ser Ala Gln Ala Gln Ala Ser Ser Pro 
545                 550                 555                 560 


Thr Leu Ser Cys Leu Asp Asn Ala Thr Glu Ala Leu Pro Ala Asp Ser 
                565                 570                 575     


Gly Pro Gly Pro Thr Pro Asp Glu Pro Cys Ile Lys Cys Pro Glu Asn 
            580                 585                 590         


Leu Gly Glu Gln Gln Leu Glu Ser Leu Glu Pro Glu Asp Pro Ser Leu 
        595                 600                 605             


Arg Ile Thr Thr Val Lys Ile Gln Thr Glu Gln Gln Arg Ile Ser Phe 
    610                 615                 620                 


Pro Pro Ser Cys Pro Asp Ala Val Val Ala Thr Pro Pro Gly Ala Ser 
625                 630                 635                 640 


Pro Pro Val Lys Asp Arg Leu Arg Val Thr Ser Ala Glu Ile Lys Leu 
                645                 650                 655     


Gly Lys Asn Arg Thr Glu Ala Glu Val Lys Arg Tyr Thr Glu Glu Lys 
            660                 665                 670         


Glu Arg Leu Glu Lys Lys Lys Glu Glu Ile Arg Gly His Leu Ala Gln 
        675                 680                 685             


Leu Arg Lys Glu Lys Arg Glu Leu Lys Glu Thr Leu Leu Lys Cys Thr 
    690                 695                 700                 


Asp Lys Glu Val Leu Ala Ser Leu Glu Gln Lys Leu Lys Glu Ile Asp 
705                 710                 715                 720 


Glu Glu Cys Arg Gly Glu Glu Ser Arg Arg Val Asp Leu Glu Leu Ser 
                725                 730                 735     


Ile Met Glu Val Lys Asp Asn Leu Lys Lys Ala Glu Ala Gly Pro Val 
            740                 745                 750         


Thr Leu Gly Thr Thr Val Asp Thr Thr His Leu Glu Asn Pro Lys Ala 
        755                 760                 765             


Val Thr Pro Ala Ser Ala Pro Asp Cys Thr Pro Val Asn Ser Ala Thr 
    770                 775                 780                 


Thr Leu Lys Asn Arg Pro Leu Ser Val Val Val Thr Gly Lys Gly Thr 
785                 790                 795                 800 


Val Leu Gln Lys Ala Lys Glu Trp Glu Lys Lys Gly Ala Ser 
                805                 810                 


<210>  2586
<211>  7620
<212>  DNA
<213>  Homosapiens

<400>  2586
gtcattgagc tgatgtgctt ttgcaagggg tctctttaga agtggtaggg gcagggtcga     60

gagaagaagg ggatgcagaa tctgtacatg aggaaggagc cagagtcact caggaaactc    120

ctcattcttc ctgcgctggc tgtggcacac ccaccggtgg cacacccctc cctcgggtcc    180

agttcagccc acagactcct gggaggagag ccagggcccc agcctctcct ttgaggagtg    240

ttgcagcctt tctgtgtgcc agatgcctag tgaagaaaag ctgaaaccct ggagctttgt    300

gcatgttaat gaccttggaa atgactgagc tcacggaccc tcatcacacc atgggagact    360

acaaagtggc ccaccctcag gaccctcacc acccatcaga gaagcctgtc attcactgcc    420

ataaatgtgg ggagccttgc aagggtgaag tgcttcgggt ccagaccaaa catttccaca    480

tcaagtgttt cacctgcaaa gtgtgtggct gtgacctggc acaagggggc ttcttcataa    540

agaacggaga gtatctctgc accctggact accagcggat gtacgggaca cgctgccatg    600

gctgtgggga gttcgtggag ggcgaagtgg tgactgctct gggcaagacc taccatccca    660

attgctttgc ttgtactatc tgcaagcgcc cgtttccacc cggagaccga gtcacattca    720

atgggagaga ctgcctttgt caactctgtg cacagccgat gtcgtccagt ccgaaagaaa    780

ccaccttctc cagcaattgt gccggctgcg gaagagatat caagaatggg caggcgctgc    840

tggcgctgga taagcagtgg cacttggggt gctttaaatg caagtcctgc gggaaggtcc    900

tcaccgggga gtacatcagc aaggatggtg ctccgtactg tgaaaaggac taccagggac    960

tctttggggt gaaatgtgag gcgtgtcacc agtttatcac agggaaagtc ctggaggcag   1020

gtgacaaaca ttaccacccc agctgtgcac gatgcagcag atgcaaccag atgttcacag   1080

aaggagagga aatgtatctt caaggctcca ccgtttggca tcccgactgt aagcaatcta   1140

cgaagaccga ggaaaagctg cggcctacca ggacatcctc ggaaagtatt tattctaggc   1200

caggctccag tattcctggc tcaccaggtc atactatcta tgcaaaagta gacaatgaga   1260

tcctggatta caaggattta gcagccattc cgaaggtcaa ggcaatttat gacattgaac   1320

gtccagatct tattacctat gagcctttct acacttcggg ctatgatgac aaacaggaga   1380

gacagagcct tggagagtct ccgaggactt tgtctcctac tccatcagca gaagggtacc   1440

aggatgttcg ggatcggatg atccatcggt ccacgagcca gggctccatc aactcccctg   1500

tgtacagccg ccacagctac actccaacca cgtcccgctc tccccagcat ttccacagac   1560

ctggcaatga gccgtccagc ggccggaact cccctctccc ttaccggcca gacagccgcc   1620

ctctaactcc aacttacgct caggccccta aacatttcca tgttccagat caaggaatca   1680

acatttaccg aaagccaccc atctacaaac agcatgctgc cttggcagcc cagagcaagt   1740

cctcagaaga tatcatcaag ttttccaagt tcccagcagc ccaggcacca gaccccagcg   1800

agacaccaaa gattgagacg gaccactggc ctggtccccc ctcatttgct gtcgtaggac   1860

ctgacatgaa acgcagatct agtggcagag aggaagatga tgaggaactt ctgagacgtc   1920

ggcagcttca agaagagcaa ttaatgaagc ttaactcagg cctgggacag ttgatcttga   1980

aagaagagat ggagaaagag agccgggaaa ggtcatctct gttagccagt cgctacgatt   2040

ctcccatcaa ctcagcttca catattccat catctaaaac tgcatctctc cctggctatg   2100

gaagaaatgg gcttcaccgg cctgtttcta ccgacttcgc tcagtataac agctatgggg   2160

atgtcagcgg gggagtgcga gattaccaga cactcccaga tggccacatg cctgcaatga   2220

gaatggaccg aggagtgtct atgcccaaca tgttggaacc aaagatattt ccatatgaaa   2280

tgctcatggt gaccaacaga gggcgaaaca aaatcctcag agaggtggac agaaccaggc   2340

tggagcgcca cttagcccct gaagtgtttc gggaaatctt tggaatgtcc atacaggagt   2400

ttgacaggtt acctctttgg agacgcaacg acatgaagaa aaaagcaaaa ctcttctaag   2460

tcccactcgt gaatggcaat tagagaaagg actgacagtg gcggtgcccc ataggatgtc   2520

atattgaggc ccaaacttga ttggagaatt tgcaaactac cgtcgctcag caacaccaaa   2580

aagagaaagt ctggttaaaa caccatgagt caaatgtcgg gccagccaac agtaacactt   2640

gccaagaagc atggcgtaga aatttctatg ttccgaaaca cagagtagtg tccacatgtg   2700

agcttttcac attaccttat gtatacaaca ggagctgcgt tgttttcttc tttttctttt   2760

cctttatctg ttgtccaaca acagtgctga ctgtccggat aagagctggc aagtgccctt   2820

aggatgccgc atgggaaaaa tcggttatca taatttcaaa gtataaatat atttattaag   2880

tagcgctgcg gctaagaagg aagagtgagg ggtctgtcca tggggtggca gtgatttcac   2940

acccgccttt cttgaatggc ttcgtgttac tcagccgtgc cctggcagga atggaactcc   3000

atcagggaac agggcagctc tgtttgaatg gggtgaaaaa cagcaaaatt aattcttagc   3060

aagctccttg ttctctactg ttcaccggga cctggctggc aaatgactta gctattagta   3120

tatttaaaaa ctgttcaaaa gcaaaagaga aggaacagga atgaaaggaa accttccctt   3180

aactctttct gcttcccata gcaggtctgg ttcctgctcc ccgcctagga caggagctgt   3240

ctggagctcc acctttgcaa agaaaggaaa aacacaaatt gcccccagat tggcccagtg   3300

gcatgccatt aggtgatttt gcataggggc catatcattc atggccaaaa aaaaccaaaa   3360

agcaaaaaac aaaaacaagt cccatgtcct actgactcta gttcttccag tcgttatcct   3420

ctgctgtctc tctggcatcc tatgaatcag atcaagccca tgctgttgtt ggtttttaag   3480

gtttctttca ataataggct aaggaaagac atgtttttct cttttaaatc tctgcaactc   3540

caaagtagac tccttcgaac gtatttaatt tggccttttc agctttcttc ttgcccagct   3600

ctgtcgaatt catgggtgtg tgtgcacatg ttggtttcac tcacccagag taattttgtg   3660

agcatgcatg tgctttttaa tttctgcttg aatgtttgtc ctgctgtgtt gcagcttcta   3720

aagacattgt caccgagtgt gtgtgactca aagatcaaga gtgaggctaa actgcgaccc   3780

caacatcact tccttcatgg aaaggtgttg gcgctgatgt agctcatgga aggatcagac   3840

tgggaaccac agaggaagga tgaggtggga tgtggaggtc agagcatctc acgagagtcc   3900

ctcaggctct gcaacactag attcgaatat gagcctaggg tttccccaac acgtgcgtgc   3960

atatgaaacc acatcatgat tcccgacgtg agttagatga gggagagttt gtgtaactcc   4020

acacccagga gggtaagcca ctttattatc atgctttggg gctgtgctta agaatttaag   4080

ctctgtttta aagccgaaga agaaaacatt tgaatttacc ttcatatgcc actaagaaca   4140

aaagctctga agttcttcct gctggcacca aatattagga ttacaagctg tctctctgac   4200

accagtggta aaaaagcaag tagaatagtt tctgagtctg tgttgcagcc tctgacacgt   4260

ggctcaccgc tgtcatttgg gggatggaat gaacagtcac tgttctatag catcctcctg   4320

tgctcttacc taaggaatct aaattgtcct agccttccat tgctatgcac tgaatgagga   4380

ctactctcgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttg   4440

gatctactaa catgtttagc aaatggctct gacagggtgg ccatgagcag atgagaccag   4500

ctcttgcttg gttggaagcc acactgcagt ttgcagttta gcctttggtg tctcagtggc   4560

ttcttgctta ttccatgctt tttctatccc atcctctctc tgtgccctcc tgcaatggca   4620

gccttggcac aatgcctggg tgtcctcatc cttgctttac tctggaaagt gtggggatgg   4680

agaggatggt gcatttccag tgcttcctta cctgtcaata acaatggtgg ccacctgggt   4740

cccagcactt ggctggtgga gagatttttt tcattatgga gctaataaag ggtccctacg   4800

ttttacattg attaatgaat tatcacccag acatgtgcag atgaaatgtc aatataagaa   4860

aaatcaaggt atttgggaaa catgggcata atcaggtagt tttgctaaaa ttcctcttcc   4920

ttggtctaca taaagaagac atgggtctgt catagaatgg ggacattaga ctgaaaactg   4980

ggacaacccc cttccttatt ttatagagac taggagttaa ggggcctgcc taagattgca   5040

gtgataaaga actgaaccct aaatcagctc ccactaatga aaccctgctt tccttgtatc   5100

ttttaaactc agttctgcat ccaacttgag aagaaaaaaa gcttctttcc atatcaagta   5160

ccatatgagt tcatttaaac tgcaccttgc agaaatgcat tgccagaaag caccagtagc   5220

ctcctatctg caagcagagt agtgctctgc tctggggagg ggtcattgga aaccataatg   5280

cagagtgggc cccctactcc atttcccagc aaaaggctcc agctggaggg atgggttgtg   5340

gggcaacctg gttcctgcta actgccagat tgaatgtgtg ggctagaatg cctgcacatt   5400

tagttaaact gggctcagca tgcttgtcct caaaatgtcc atcctggtca cagcacacaa   5460

gatggctatt ggtctgcttt taccctaccc tgtactatac atgaaaattc cagttattaa   5520

cacactcaaa ctggtggagc ttgttcaccc taggaagggg attgtatata tggcaggctt   5580

ccctggtgcc gatgtaaagg gctacatttg ggaacatttg acttccttgg gactcttaag   5640

tgcataatga tggcatgaag taaaaggggc ctcaatgatg ataggaaaat cagttctttt   5700

aaaatttctt caagaaaatc caggctatca catagtcttt ctgtgtgact tattaggaga   5760

taggaagagc attgggaaac ttgcacagct agctatgcat ctacattttg gtttggggtt   5820

agttatgaaa tgttcttaat atgacgtgtt caataacttc acataaactt cctgttctcc   5880

aaaacctcaa agagatagag ttaatgagtt gttgtttttt tttaaatggg ggtagttttc   5940

tatctgtcat gggctctagc atctactccg ctacccaatt ctgtcatctc caagctgagt   6000

ttcctcttct gaggcagagg ctggagcagt tctttttcag ttctcatcct ctccatccca   6060

atccagtata tcaatcaact ctaactcgga gacgtctagc tggcaatgtt tctaaaactt   6120

tcactggatt tctttagaca ttgaagcaaa catttttttc taagaattgc ttctcagatg   6180

atgatatcaa atgtatatgc ttttgcaagt ttgaaaagtt caaattaacc acttttgact   6240

aggtaagtct ttctaaaaac catttaaagc taactgggtc ttagcatcct cctgtgtatg   6300

gaagagacag gtgaccgctc caggttgggt gctcacagaa cccttttcct gactctcatg   6360

gaagatggtg gaaggaaaat agactgtctc atcaaccctc ctgtgtcctc tgaagcaatc   6420

tcagttttta ttaaccacct cttctgtgtt tctggtagct atttaacctg tatttaatct   6480

gtacttccta tgccagcctc aattttattt gatttttaca attattctct tctaaccaat   6540

gaagtgtttg tcagtatgcc ccaaagcttg ctcttttgtg ctcccttttg aataactttc   6600

tatccagaaa aagagattat ttgggacttg agatttgcag tgataccaac ttatagcaat   6660

gatgtacttt aagggaacta cccaactatg ttgtgataga agaaagagaa accttcactt   6720

tggcattttt ttttaatcac tgtttatttt tctgtttgcg gcccaggaag cagtgggagg   6780

tggtggcaga tatgctttgc atatggattg ttatgttttt atttgggcaa gtttaatcat   6840

ggaaaactca aaaagaaggg gggaaatggt cagtttaagc caaaagaaac tttctaaaca   6900

atgtataggt acacagcaaa attaaacaaa tccaacaatt tctgaagctt agtgtaattg   6960

agtggtggtt gttattcaat aaaattattc ccaaaagtgt ttctcctaag agtgcagttc   7020

ccatgagtca cttcctgaac ccattgacca aaggtggaca gagacaatcc tgtagacctt   7080

gacattcaga aagatgtgag ctgcttactg atcatatatg catacgtttc tttacagcag   7140

aggaaaccat tgtccacaaa actgatgttc ttttggggtt ttatgtacag acttgtccaa   7200

tcatgtgtgt ggttcctgcg agttgctgat gactccgcat tgaagctctc tgagttcttt   7260

gattttaagt tgggtttatg gaattttttc aaatgttgga aggtgtgtgg ttcttcctgc   7320

cctccctccc cttttggaaa tatgaaagca aatgtttaga agaattcctt ttgaaaagct   7380

gtgtcgtgtt ccctgtgaaa ctgagcaggt gtgtgttggc gcgctaagtg ccacatgctt   7440

gtgtgtagag gaggaggtgg ccctgccggc tccgcgctgc tgtgcctgtg atccctacct   7500

gctccccgct cctgttgcca gcagcactca ctgcactcct ttgtcatata ctctgcatca   7560

ctgtcatact cacaacttcg tgaataaagt tgtgtgcttt attcgtagaa aaaaaaaaaa   7620


<210>  2587
<211>  718
<212>  PRT
<213>  Homosapiens

<400>  2587

Met Leu Met Thr Leu Glu Met Thr Glu Leu Thr Asp Pro His His Thr 
1               5                   10                  15      


Met Gly Asp Tyr Lys Val Ala His Pro Gln Asp Pro His His Pro Ser 
            20                  25                  30          


Glu Lys Pro Val Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly 
        35                  40                  45              


Glu Val Leu Arg Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr 
    50                  55                  60                  


Cys Lys Val Cys Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys 
65                  70                  75                  80  


Asn Gly Glu Tyr Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr 
                85                  90                  95      


Arg Cys His Gly Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala 
            100                 105                 110         


Leu Gly Lys Thr Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys 
        115                 120                 125             


Arg Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys 
    130                 135                 140                 


Leu Cys Gln Leu Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr 
145                 150                 155                 160 


Thr Phe Ser Ser Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly 
                165                 170                 175     


Gln Ala Leu Leu Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys 
            180                 185                 190         


Cys Lys Ser Cys Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp 
        195                 200                 205             


Gly Ala Pro Tyr Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys 
    210                 215                 220                 


Cys Glu Ala Cys His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly 
225                 230                 235                 240 


Asp Lys His Tyr His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln 
                245                 250                 255     


Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
            260                 265                 270         


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro 
        275                 280                 285             


Thr Arg Thr Ser Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile 
    290                 295                 300                 


Pro Gly Ser Pro Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile 
305                 310                 315                 320 


Leu Asp Tyr Lys Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr 
                325                 330                 335     


Asp Ile Glu Arg Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser 
            340                 345                 350         


Gly Tyr Asp Asp Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg 
        355                 360                 365             


Thr Leu Ser Pro Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp 
    370                 375                 380                 


Arg Met Ile His Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val 
385                 390                 395                 400 


Tyr Ser Arg His Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His 
                405                 410                 415     


Phe His Arg Pro Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu 
            420                 425                 430         


Pro Tyr Arg Pro Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala 
        435                 440                 445             


Pro Lys His Phe His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys 
    450                 455                 460                 


Pro Pro Ile Tyr Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser 
465                 470                 475                 480 


Ser Glu Asp Ile Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro 
                485                 490                 495     


Asp Pro Ser Glu Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro 
            500                 505                 510         


Pro Ser Phe Ala Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly 
        515                 520                 525             


Arg Glu Glu Asp Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu 
    530                 535                 540                 


Glu Gln Leu Met Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys 
545                 550                 555                 560 


Glu Glu Met Glu Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser 
                565                 570                 575     


Arg Tyr Asp Ser Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys 
            580                 585                 590         


Thr Ala Ser Leu Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val 
        595                 600                 605             


Ser Thr Asp Phe Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly 
    610                 615                 620                 


Val Arg Asp Tyr Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg 
625                 630                 635                 640 


Met Asp Arg Gly Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe 
                645                 650                 655     


Pro Tyr Glu Met Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu 
            660                 665                 670         


Arg Glu Val Asp Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val 
        675                 680                 685             


Phe Arg Glu Ile Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro 
    690                 695                 700                 


Leu Trp Arg Arg Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
705                 710                 715             


<210>  2588
<211>  7704
<212>  DNA
<213>  Homosapiens

<400>  2588
gtcattgagc tgatgtgctt ttgcaagggg tctctttaga agtggtaggg gcagggtcga     60

gagaagaagg ggatgcagaa tctgtacatg aggaaggagc cagagtcact caggaaactc    120

ctcattcttc ctgcgctggc tgtggcacac ccaccggtgg cacacccctc cctcgggtcc    180

agttcagccc acagactcct gggaggagag ccagggcccc agcctctcct ttgaggagtg    240

ttgcagcctt tctgtgtgcc agatgcctag tgaagaaaag ctgaaaccct ggagctttgt    300

gcatgttaat gaccttggaa atgactgagc tcacggaccc tcatcacacc atgggagact    360

acaaagtggc ccaccctcag gaccctcacc acccatcaga gaagcctgtc attcactgcc    420

ataaatgtgg ggagccttgc aagggtgaag tgcttcgggt ccagaccaaa catttccaca    480

tcaagtgttt cacctgcaaa gtgtgtggct gtgacctggc acaagggggc ttcttcataa    540

agaacggaga gtatctctgc accctggact accagcggat gtacgggaca cgctgccatg    600

gctgtgggga gttcgtggag ggcgaagtgg tgactgctct gggcaagacc taccatccca    660

attgctttgc ttgtactatc tgcaagcgcc cgtttccacc cggagaccga gtcacattca    720

atgggagaga ctgcctttgt caactctgtg cacagccgat gtcgtccagt ccgaaagaaa    780

ccaccttctc cagcaattgt gccggctgcg gaagagatat caagaatggg caggcgctgc    840

tggcgctgga taagcagtgg cacttggggt gctttaaatg caagtcctgc gggaaggtcc    900

tcaccgggga gtacatcagc aaggatggtg ctccgtactg tgaaaaggac taccagggac    960

tctttggggt gaaatgtgag gcgtgtcacc agtttatcac agggaaagtc ctggaggcag   1020

gtgacaaaca ttaccacccc agctgtgcac gatgcagcag atgcaaccag atgttcacag   1080

aaggagagga aatgtatctt caaggctcca ccgtttggca tcccgactgt aagcaatcta   1140

cgaagaccga ggaaaagctg cggctgccaa acattcggcg ttcttcatcc gatttctttt   1200

attccaaaag tctgattcga cgcacaggac ggtctccgtc tctgcagcct accaggacat   1260

cctcggaaag tatttattct aggccaggct ccagtattcc tggctcacca ggtcatacta   1320

tctatgcaaa agtagacaat gagatcctgg attacaagga tttagcagcc attccgaagg   1380

tcaaggcaat ttatgacatt gaacgtccag atcttattac ctatgagcct ttctacactt   1440

cgggctatga tgacaaacag gagagacaga gccttggaga gtctccgagg actttgtctc   1500

ctactccatc agcagaaggg taccaggatg ttcgggatcg gatgatccat cggtccacga   1560

gccagggctc catcaactcc cctgtgtaca gccgccacag ctacactcca accacgtccc   1620

gctctcccca gcatttccac agacctggca atgagccgtc cagcggccgg aactcccctc   1680

tcccttaccg gccagacagc cgccctctaa ctccaactta cgctcaggcc cctaaacatt   1740

tccatgttcc agatcaagga atcaacattt accgaaagcc acccatctac aaacagcatg   1800

ctgccttggc agcccagagc aagtcctcag aagatatcat caagttttcc aagttcccag   1860

cagcccaggc accagacccc agcgagacac caaagattga gacggaccac tggcctggtc   1920

ccccctcatt tgctgtcgta ggacctgaca tgaaacgcag atctagtggc agagaggaag   1980

atgatgagga acttctgaga cgtcggcagc ttcaagaaga gcaattaatg aagcttaact   2040

caggcctggg acagttgatc ttgaaagaag agatggagaa agagagccgg gaaaggtcat   2100

ctctgttagc cagtcgctac gattctccca tcaactcagc ttcacatatt ccatcatcta   2160

aaactgcatc tctccctggc tatggaagaa atgggcttca ccggcctgtt tctaccgact   2220

tcgctcagta taacagctat ggggatgtca gcgggggagt gcgagattac cagacactcc   2280

cagatggcca catgcctgca atgagaatgg accgaggagt gtctatgccc aacatgttgg   2340

aaccaaagat atttccatat gaaatgctca tggtgaccaa cagagggcga aacaaaatcc   2400

tcagagaggt ggacagaacc aggctggagc gccacttagc ccctgaagtg tttcgggaaa   2460

tctttggaat gtccatacag gagtttgaca ggttacctct ttggagacgc aacgacatga   2520

agaaaaaagc aaaactcttc taagtcccac tcgtgaatgg caattagaga aaggactgac   2580

agtggcggtg ccccatagga tgtcatattg aggcccaaac ttgattggag aatttgcaaa   2640

ctaccgtcgc tcagcaacac caaaaagaga aagtctggtt aaaacaccat gagtcaaatg   2700

tcgggccagc caacagtaac acttgccaag aagcatggcg tagaaatttc tatgttccga   2760

aacacagagt agtgtccaca tgtgagcttt tcacattacc ttatgtatac aacaggagct   2820

gcgttgtttt cttctttttc ttttccttta tctgttgtcc aacaacagtg ctgactgtcc   2880

ggataagagc tggcaagtgc ccttaggatg ccgcatggga aaaatcggtt atcataattt   2940

caaagtataa atatatttat taagtagcgc tgcggctaag aaggaagagt gaggggtctg   3000

tccatggggt ggcagtgatt tcacacccgc ctttcttgaa tggcttcgtg ttactcagcc   3060

gtgccctggc aggaatggaa ctccatcagg gaacagggca gctctgtttg aatggggtga   3120

aaaacagcaa aattaattct tagcaagctc cttgttctct actgttcacc gggacctggc   3180

tggcaaatga cttagctatt agtatattta aaaactgttc aaaagcaaaa gagaaggaac   3240

aggaatgaaa ggaaaccttc ccttaactct ttctgcttcc catagcaggt ctggttcctg   3300

ctccccgcct aggacaggag ctgtctggag ctccaccttt gcaaagaaag gaaaaacaca   3360

aattgccccc agattggccc agtggcatgc cattaggtga ttttgcatag gggccatatc   3420

attcatggcc aaaaaaaacc aaaaagcaaa aaacaaaaac aagtcccatg tcctactgac   3480

tctagttctt ccagtcgtta tcctctgctg tctctctggc atcctatgaa tcagatcaag   3540

cccatgctgt tgttggtttt taaggtttct ttcaataata ggctaaggaa agacatgttt   3600

ttctctttta aatctctgca actccaaagt agactccttc gaacgtattt aatttggcct   3660

tttcagcttt cttcttgccc agctctgtcg aattcatggg tgtgtgtgca catgttggtt   3720

tcactcaccc agagtaattt tgtgagcatg catgtgcttt ttaatttctg cttgaatgtt   3780

tgtcctgctg tgttgcagct tctaaagaca ttgtcaccga gtgtgtgtga ctcaaagatc   3840

aagagtgagg ctaaactgcg accccaacat cacttccttc atggaaaggt gttggcgctg   3900

atgtagctca tggaaggatc agactgggaa ccacagagga aggatgaggt gggatgtgga   3960

ggtcagagca tctcacgaga gtccctcagg ctctgcaaca ctagattcga atatgagcct   4020

agggtttccc caacacgtgc gtgcatatga aaccacatca tgattcccga cgtgagttag   4080

atgagggaga gtttgtgtaa ctccacaccc aggagggtaa gccactttat tatcatgctt   4140

tggggctgtg cttaagaatt taagctctgt tttaaagccg aagaagaaaa catttgaatt   4200

taccttcata tgccactaag aacaaaagct ctgaagttct tcctgctggc accaaatatt   4260

aggattacaa gctgtctctc tgacaccagt ggtaaaaaag caagtagaat agtttctgag   4320

tctgtgttgc agcctctgac acgtggctca ccgctgtcat ttgggggatg gaatgaacag   4380

tcactgttct atagcatcct cctgtgctct tacctaagga atctaaattg tcctagcctt   4440

ccattgctat gcactgaatg aggactactc tcgtgtgtgt gtgtgtgtgt gtgtgtgtgt   4500

gtgtgtgtgt gtgtgtgtgt gttggatcta ctaacatgtt tagcaaatgg ctctgacagg   4560

gtggccatga gcagatgaga ccagctcttg cttggttgga agccacactg cagtttgcag   4620

tttagccttt ggtgtctcag tggcttcttg cttattccat gctttttcta tcccatcctc   4680

tctctgtgcc ctcctgcaat ggcagccttg gcacaatgcc tgggtgtcct catccttgct   4740

ttactctgga aagtgtgggg atggagagga tggtgcattt ccagtgcttc cttacctgtc   4800

aataacaatg gtggccacct gggtcccagc acttggctgg tggagagatt tttttcatta   4860

tggagctaat aaagggtccc tacgttttac attgattaat gaattatcac ccagacatgt   4920

gcagatgaaa tgtcaatata agaaaaatca aggtatttgg gaaacatggg cataatcagg   4980

tagttttgct aaaattcctc ttccttggtc tacataaaga agacatgggt ctgtcataga   5040

atggggacat tagactgaaa actgggacaa cccccttcct tattttatag agactaggag   5100

ttaaggggcc tgcctaagat tgcagtgata aagaactgaa ccctaaatca gctcccacta   5160

atgaaaccct gctttccttg tatcttttaa actcagttct gcatccaact tgagaagaaa   5220

aaaagcttct ttccatatca agtaccatat gagttcattt aaactgcacc ttgcagaaat   5280

gcattgccag aaagcaccag tagcctccta tctgcaagca gagtagtgct ctgctctggg   5340

gaggggtcat tggaaaccat aatgcagagt gggcccccta ctccatttcc cagcaaaagg   5400

ctccagctgg agggatgggt tgtggggcaa cctggttcct gctaactgcc agattgaatg   5460

tgtgggctag aatgcctgca catttagtta aactgggctc agcatgcttg tcctcaaaat   5520

gtccatcctg gtcacagcac acaagatggc tattggtctg cttttaccct accctgtact   5580

atacatgaaa attccagtta ttaacacact caaactggtg gagcttgttc accctaggaa   5640

ggggattgta tatatggcag gcttccctgg tgccgatgta aagggctaca tttgggaaca   5700

tttgacttcc ttgggactct taagtgcata atgatggcat gaagtaaaag gggcctcaat   5760

gatgatagga aaatcagttc ttttaaaatt tcttcaagaa aatccaggct atcacatagt   5820

ctttctgtgt gacttattag gagataggaa gagcattggg aaacttgcac agctagctat   5880

gcatctacat tttggtttgg ggttagttat gaaatgttct taatatgacg tgttcaataa   5940

cttcacataa acttcctgtt ctccaaaacc tcaaagagat agagttaatg agttgttgtt   6000

tttttttaaa tgggggtagt tttctatctg tcatgggctc tagcatctac tccgctaccc   6060

aattctgtca tctccaagct gagtttcctc ttctgaggca gaggctggag cagttctttt   6120

tcagttctca tcctctccat cccaatccag tatatcaatc aactctaact cggagacgtc   6180

tagctggcaa tgtttctaaa actttcactg gatttcttta gacattgaag caaacatttt   6240

tttctaagaa ttgcttctca gatgatgata tcaaatgtat atgcttttgc aagtttgaaa   6300

agttcaaatt aaccactttt gactaggtaa gtctttctaa aaaccattta aagctaactg   6360

ggtcttagca tcctcctgtg tatggaagag acaggtgacc gctccaggtt gggtgctcac   6420

agaacccttt tcctgactct catggaagat ggtggaagga aaatagactg tctcatcaac   6480

cctcctgtgt cctctgaagc aatctcagtt tttattaacc acctcttctg tgtttctggt   6540

agctatttaa cctgtattta atctgtactt cctatgccag cctcaatttt atttgatttt   6600

tacaattatt ctcttctaac caatgaagtg tttgtcagta tgccccaaag cttgctcttt   6660

tgtgctccct tttgaataac tttctatcca gaaaaagaga ttatttggga cttgagattt   6720

gcagtgatac caacttatag caatgatgta ctttaaggga actacccaac tatgttgtga   6780

tagaagaaag agaaaccttc actttggcat ttttttttaa tcactgttta tttttctgtt   6840

tgcggcccag gaagcagtgg gaggtggtgg cagatatgct ttgcatatgg attgttatgt   6900

ttttatttgg gcaagtttaa tcatggaaaa ctcaaaaaga aggggggaaa tggtcagttt   6960

aagccaaaag aaactttcta aacaatgtat aggtacacag caaaattaaa caaatccaac   7020

aatttctgaa gcttagtgta attgagtggt ggttgttatt caataaaatt attcccaaaa   7080

gtgtttctcc taagagtgca gttcccatga gtcacttcct gaacccattg accaaaggtg   7140

gacagagaca atcctgtaga ccttgacatt cagaaagatg tgagctgctt actgatcata   7200

tatgcatacg tttctttaca gcagaggaaa ccattgtcca caaaactgat gttcttttgg   7260

ggttttatgt acagacttgt ccaatcatgt gtgtggttcc tgcgagttgc tgatgactcc   7320

gcattgaagc tctctgagtt ctttgatttt aagttgggtt tatggaattt tttcaaatgt   7380

tggaaggtgt gtggttcttc ctgccctccc tccccttttg gaaatatgaa agcaaatgtt   7440

tagaagaatt ccttttgaaa agctgtgtcg tgttccctgt gaaactgagc aggtgtgtgt   7500

tggcgcgcta agtgccacat gcttgtgtgt agaggaggag gtggccctgc cggctccgcg   7560

ctgctgtgcc tgtgatccct acctgctccc cgctcctgtt gccagcagca ctcactgcac   7620

tcctttgtca tatactctgc atcactgtca tactcacaac ttcgtgaata aagttgtgtg   7680

ctttattcgt agaaaaaaaa aaaa                                          7704


<210>  2589
<211>  746
<212>  PRT
<213>  Homosapiens

<400>  2589

Met Leu Met Thr Leu Glu Met Thr Glu Leu Thr Asp Pro His His Thr 
1               5                   10                  15      


Met Gly Asp Tyr Lys Val Ala His Pro Gln Asp Pro His His Pro Ser 
            20                  25                  30          


Glu Lys Pro Val Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly 
        35                  40                  45              


Glu Val Leu Arg Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr 
    50                  55                  60                  


Cys Lys Val Cys Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys 
65                  70                  75                  80  


Asn Gly Glu Tyr Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr 
                85                  90                  95      


Arg Cys His Gly Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala 
            100                 105                 110         


Leu Gly Lys Thr Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys 
        115                 120                 125             


Arg Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys 
    130                 135                 140                 


Leu Cys Gln Leu Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr 
145                 150                 155                 160 


Thr Phe Ser Ser Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly 
                165                 170                 175     


Gln Ala Leu Leu Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys 
            180                 185                 190         


Cys Lys Ser Cys Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp 
        195                 200                 205             


Gly Ala Pro Tyr Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys 
    210                 215                 220                 


Cys Glu Ala Cys His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly 
225                 230                 235                 240 


Asp Lys His Tyr His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln 
                245                 250                 255     


Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
            260                 265                 270         


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Leu 
        275                 280                 285             


Pro Asn Ile Arg Arg Ser Ser Ser Asp Phe Phe Tyr Ser Lys Ser Leu 
    290                 295                 300                 


Ile Arg Arg Thr Gly Arg Ser Pro Ser Leu Gln Pro Thr Arg Thr Ser 
305                 310                 315                 320 


Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser Pro 
                325                 330                 335     


Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys 
            340                 345                 350         


Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg 
        355                 360                 365             


Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp 
    370                 375                 380                 


Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro 
385                 390                 395                 400 


Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile His 
                405                 410                 415     


Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg His 
            420                 425                 430         


Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His Phe His Arg Pro 
        435                 440                 445             


Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu Pro Tyr Arg Pro 
    450                 455                 460                 


Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala Pro Lys His Phe 
465                 470                 475                 480 


His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys Pro Pro Ile Tyr 
                485                 490                 495     


Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser Ser Glu Asp Ile 
            500                 505                 510         


Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro Asp Pro Ser Glu 
        515                 520                 525             


Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro Pro Ser Phe Ala 
    530                 535                 540                 


Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly Arg Glu Glu Asp 
545                 550                 555                 560 


Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu Glu Gln Leu Met 
                565                 570                 575     


Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys Glu Glu Met Glu 
            580                 585                 590         


Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser Arg Tyr Asp Ser 
        595                 600                 605             


Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys Thr Ala Ser Leu 
    610                 615                 620                 


Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val Ser Thr Asp Phe 
625                 630                 635                 640 


Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly Val Arg Asp Tyr 
                645                 650                 655     


Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg Met Asp Arg Gly 
            660                 665                 670         


Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe Pro Tyr Glu Met 
        675                 680                 685             


Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu Arg Glu Val Asp 
    690                 695                 700                 


Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val Phe Arg Glu Ile 
705                 710                 715                 720 


Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro Leu Trp Arg Arg 
                725                 730                 735     


Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
            740                 745     


<210>  2590
<211>  7597
<212>  DNA
<213>  Homosapiens

<400>  2590
gagacagtaa ggagccaggg gaacagagag aattgtgggg cagcaccgct ccttgggtcc     60

ccactcccca tttctcattg cttggaaatc catgccaaga tgcctgcctt ccttggtcta    120

aagtgtctgg ggaaattgtg cagctctgag aaaagcaaag tcacctcatc tgagagaacc    180

agtgccaggg gctcgaacag aaagagactg attgttgagg accggagggt ctctgggacc    240

tccttcaccg ctcataggcg tgccactatc actcatttgc tgtatctctg tcccaaggac    300

tactgcccac gtgggcgtgt atgtaacagc gttgatcctt ttgtggccca ccctcaggac    360

cctcaccacc catcagagaa gcctgtcatt cactgccata aatgtgggga gccttgcaag    420

ggtgaagtgc ttcgggtcca gaccaaacat ttccacatca agtgtttcac ctgcaaagtg    480

tgtggctgtg acctggcaca agggggcttc ttcataaaga acggagagta tctctgcacc    540

ctggactacc agcggatgta cgggacacgc tgccatggct gtggggagtt cgtggagggc    600

gaagtggtga ctgctctggg caagacctac catcccaatt gctttgcttg tactatctgc    660

aagcgcccgt ttccacccgg agaccgagtc acattcaatg ggagagactg cctttgtcaa    720

ctctgtgcac agccgatgtc gtccagtccg aaagaaacca ccttctccag caattgtgcc    780

ggctgcggaa gagatatcaa gaatgggcag gcgctgctgg cgctggataa gcagtggcac    840

ttggggtgct ttaaatgcaa gtcctgcggg aaggtcctca ccggggagta catcagcaag    900

gatggtgctc cgtactgtga aaaggactac cagggactct ttggggtgaa atgtgaggcg    960

tgtcaccagt ttatcacagg gaaagtcctg gaggcaggtg acaaacatta ccaccccagc   1020

tgtgcacgat gcagcagatg caaccagatg ttcacagaag gagaggaaat gtatcttcaa   1080

ggctccaccg tttggcatcc cgactgtaag caatctacga agaccgagga aaagctgcgg   1140

cctaccagga catcctcgga aagtatttat tctaggccag gctccagtat tcctggctca   1200

ccaggtcata ctatctatgc aaaagtagac aatgagatcc tggattacaa ggatttagca   1260

gccattccga aggtcaaggc aatttatgac attgaacgtc cagatcttat tacctatgag   1320

cctttctaca cttcgggcta tgatgacaaa caggagagac agagccttgg agagtctccg   1380

aggactttgt ctcctactcc atcagcagaa gggtaccagg atgttcggga tcggatgatc   1440

catcggtcca cgagccaggg ctccatcaac tcccctgtgt acagccgcca cagctacact   1500

ccaaccacgt cccgctctcc ccagcatttc cacagacctg gcaatgagcc gtccagcggc   1560

cggaactccc ctctccctta ccggccagac agccgccctc taactccaac ttacgctcag   1620

gcccctaaac atttccatgt tccagatcaa ggaatcaaca tttaccgaaa gccacccatc   1680

tacaaacagc atgctgcctt ggcagcccag agcaagtcct cagaagatat catcaagttt   1740

tccaagttcc cagcagccca ggcaccagac cccagcgaga caccaaagat tgagacggac   1800

cactggcctg gtcccccctc atttgctgtc gtaggacctg acatgaaacg cagatctagt   1860

ggcagagagg aagatgatga ggaacttctg agacgtcggc agcttcaaga agagcaatta   1920

atgaagctta actcaggcct gggacagttg atcttgaaag aagagatgga gaaagagagc   1980

cgggaaaggt catctctgtt agccagtcgc tacgattctc ccatcaactc agcttcacat   2040

attccatcat ctaaaactgc atctctccct ggctatggaa gaaatgggct tcaccggcct   2100

gtttctaccg acttcgctca gtataacagc tatggggatg tcagcggggg agtgcgagat   2160

taccagacac tcccagatgg ccacatgcct gcaatgagaa tggaccgagg agtgtctatg   2220

cccaacatgt tggaaccaaa gatatttcca tatgaaatgc tcatggtgac caacagaggg   2280

cgaaacaaaa tcctcagaga ggtggacaga accaggctgg agcgccactt agcccctgaa   2340

gtgtttcggg aaatctttgg aatgtccata caggagtttg acaggttacc tctttggaga   2400

cgcaacgaca tgaagaaaaa agcaaaactc ttctaagtcc cactcgtgaa tggcaattag   2460

agaaaggact gacagtggcg gtgccccata ggatgtcata ttgaggccca aacttgattg   2520

gagaatttgc aaactaccgt cgctcagcaa caccaaaaag agaaagtctg gttaaaacac   2580

catgagtcaa atgtcgggcc agccaacagt aacacttgcc aagaagcatg gcgtagaaat   2640

ttctatgttc cgaaacacag agtagtgtcc acatgtgagc ttttcacatt accttatgta   2700

tacaacagga gctgcgttgt tttcttcttt ttcttttcct ttatctgttg tccaacaaca   2760

gtgctgactg tccggataag agctggcaag tgcccttagg atgccgcatg ggaaaaatcg   2820

gttatcataa tttcaaagta taaatatatt tattaagtag cgctgcggct aagaaggaag   2880

agtgaggggt ctgtccatgg ggtggcagtg atttcacacc cgcctttctt gaatggcttc   2940

gtgttactca gccgtgccct ggcaggaatg gaactccatc agggaacagg gcagctctgt   3000

ttgaatgggg tgaaaaacag caaaattaat tcttagcaag ctccttgttc tctactgttc   3060

accgggacct ggctggcaaa tgacttagct attagtatat ttaaaaactg ttcaaaagca   3120

aaagagaagg aacaggaatg aaaggaaacc ttcccttaac tctttctgct tcccatagca   3180

ggtctggttc ctgctccccg cctaggacag gagctgtctg gagctccacc tttgcaaaga   3240

aaggaaaaac acaaattgcc cccagattgg cccagtggca tgccattagg tgattttgca   3300

taggggccat atcattcatg gccaaaaaaa accaaaaagc aaaaaacaaa aacaagtccc   3360

atgtcctact gactctagtt cttccagtcg ttatcctctg ctgtctctct ggcatcctat   3420

gaatcagatc aagcccatgc tgttgttggt ttttaaggtt tctttcaata ataggctaag   3480

gaaagacatg tttttctctt ttaaatctct gcaactccaa agtagactcc ttcgaacgta   3540

tttaatttgg ccttttcagc tttcttcttg cccagctctg tcgaattcat gggtgtgtgt   3600

gcacatgttg gtttcactca cccagagtaa ttttgtgagc atgcatgtgc tttttaattt   3660

ctgcttgaat gtttgtcctg ctgtgttgca gcttctaaag acattgtcac cgagtgtgtg   3720

tgactcaaag atcaagagtg aggctaaact gcgaccccaa catcacttcc ttcatggaaa   3780

ggtgttggcg ctgatgtagc tcatggaagg atcagactgg gaaccacaga ggaaggatga   3840

ggtgggatgt ggaggtcaga gcatctcacg agagtccctc aggctctgca acactagatt   3900

cgaatatgag cctagggttt ccccaacacg tgcgtgcata tgaaaccaca tcatgattcc   3960

cgacgtgagt tagatgaggg agagtttgtg taactccaca cccaggaggg taagccactt   4020

tattatcatg ctttggggct gtgcttaaga atttaagctc tgttttaaag ccgaagaaga   4080

aaacatttga atttaccttc atatgccact aagaacaaaa gctctgaagt tcttcctgct   4140

ggcaccaaat attaggatta caagctgtct ctctgacacc agtggtaaaa aagcaagtag   4200

aatagtttct gagtctgtgt tgcagcctct gacacgtggc tcaccgctgt catttggggg   4260

atggaatgaa cagtcactgt tctatagcat cctcctgtgc tcttacctaa ggaatctaaa   4320

ttgtcctagc cttccattgc tatgcactga atgaggacta ctctcgtgtg tgtgtgtgtg   4380

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttggat ctactaacat gtttagcaaa   4440

tggctctgac agggtggcca tgagcagatg agaccagctc ttgcttggtt ggaagccaca   4500

ctgcagtttg cagtttagcc tttggtgtct cagtggcttc ttgcttattc catgcttttt   4560

ctatcccatc ctctctctgt gccctcctgc aatggcagcc ttggcacaat gcctgggtgt   4620

cctcatcctt gctttactct ggaaagtgtg gggatggaga ggatggtgca tttccagtgc   4680

ttccttacct gtcaataaca atggtggcca cctgggtccc agcacttggc tggtggagag   4740

atttttttca ttatggagct aataaagggt ccctacgttt tacattgatt aatgaattat   4800

cacccagaca tgtgcagatg aaatgtcaat ataagaaaaa tcaaggtatt tgggaaacat   4860

gggcataatc aggtagtttt gctaaaattc ctcttccttg gtctacataa agaagacatg   4920

ggtctgtcat agaatgggga cattagactg aaaactggga caaccccctt ccttatttta   4980

tagagactag gagttaaggg gcctgcctaa gattgcagtg ataaagaact gaaccctaaa   5040

tcagctccca ctaatgaaac cctgctttcc ttgtatcttt taaactcagt tctgcatcca   5100

acttgagaag aaaaaaagct tctttccata tcaagtacca tatgagttca tttaaactgc   5160

accttgcaga aatgcattgc cagaaagcac cagtagcctc ctatctgcaa gcagagtagt   5220

gctctgctct ggggaggggt cattggaaac cataatgcag agtgggcccc ctactccatt   5280

tcccagcaaa aggctccagc tggagggatg ggttgtgggg caacctggtt cctgctaact   5340

gccagattga atgtgtgggc tagaatgcct gcacatttag ttaaactggg ctcagcatgc   5400

ttgtcctcaa aatgtccatc ctggtcacag cacacaagat ggctattggt ctgcttttac   5460

cctaccctgt actatacatg aaaattccag ttattaacac actcaaactg gtggagcttg   5520

ttcaccctag gaaggggatt gtatatatgg caggcttccc tggtgccgat gtaaagggct   5580

acatttggga acatttgact tccttgggac tcttaagtgc ataatgatgg catgaagtaa   5640

aaggggcctc aatgatgata ggaaaatcag ttcttttaaa atttcttcaa gaaaatccag   5700

gctatcacat agtctttctg tgtgacttat taggagatag gaagagcatt gggaaacttg   5760

cacagctagc tatgcatcta cattttggtt tggggttagt tatgaaatgt tcttaatatg   5820

acgtgttcaa taacttcaca taaacttcct gttctccaaa acctcaaaga gatagagtta   5880

atgagttgtt gttttttttt aaatgggggt agttttctat ctgtcatggg ctctagcatc   5940

tactccgcta cccaattctg tcatctccaa gctgagtttc ctcttctgag gcagaggctg   6000

gagcagttct ttttcagttc tcatcctctc catcccaatc cagtatatca atcaactcta   6060

actcggagac gtctagctgg caatgtttct aaaactttca ctggatttct ttagacattg   6120

aagcaaacat ttttttctaa gaattgcttc tcagatgatg atatcaaatg tatatgcttt   6180

tgcaagtttg aaaagttcaa attaaccact tttgactagg taagtctttc taaaaaccat   6240

ttaaagctaa ctgggtctta gcatcctcct gtgtatggaa gagacaggtg accgctccag   6300

gttgggtgct cacagaaccc ttttcctgac tctcatggaa gatggtggaa ggaaaataga   6360

ctgtctcatc aaccctcctg tgtcctctga agcaatctca gtttttatta accacctctt   6420

ctgtgtttct ggtagctatt taacctgtat ttaatctgta cttcctatgc cagcctcaat   6480

tttatttgat ttttacaatt attctcttct aaccaatgaa gtgtttgtca gtatgcccca   6540

aagcttgctc ttttgtgctc ccttttgaat aactttctat ccagaaaaag agattatttg   6600

ggacttgaga tttgcagtga taccaactta tagcaatgat gtactttaag ggaactaccc   6660

aactatgttg tgatagaaga aagagaaacc ttcactttgg catttttttt taatcactgt   6720

ttatttttct gtttgcggcc caggaagcag tgggaggtgg tggcagatat gctttgcata   6780

tggattgtta tgtttttatt tgggcaagtt taatcatgga aaactcaaaa agaagggggg   6840

aaatggtcag tttaagccaa aagaaacttt ctaaacaatg tataggtaca cagcaaaatt   6900

aaacaaatcc aacaatttct gaagcttagt gtaattgagt ggtggttgtt attcaataaa   6960

attattccca aaagtgtttc tcctaagagt gcagttccca tgagtcactt cctgaaccca   7020

ttgaccaaag gtggacagag acaatcctgt agaccttgac attcagaaag atgtgagctg   7080

cttactgatc atatatgcat acgtttcttt acagcagagg aaaccattgt ccacaaaact   7140

gatgttcttt tggggtttta tgtacagact tgtccaatca tgtgtgtggt tcctgcgagt   7200

tgctgatgac tccgcattga agctctctga gttctttgat tttaagttgg gtttatggaa   7260

ttttttcaaa tgttggaagg tgtgtggttc ttcctgccct ccctcccctt ttggaaatat   7320

gaaagcaaat gtttagaaga attccttttg aaaagctgtg tcgtgttccc tgtgaaactg   7380

agcaggtgtg tgttggcgcg ctaagtgcca catgcttgtg tgtagaggag gaggtggccc   7440

tgccggctcc gcgctgctgt gcctgtgatc cctacctgct ccccgctcct gttgccagca   7500

gcactcactg cactcctttg tcatatactc tgcatcactg tcatactcac aacttcgtga   7560

ataaagttgt gtgctttatt cgtagaaaaa aaaaaaa                            7597


<210>  2591
<211>  778
<212>  PRT
<213>  Homosapiens

<400>  2591

Met Pro Ala Phe Leu Gly Leu Lys Cys Leu Gly Lys Leu Cys Ser Ser 
1               5                   10                  15      


Glu Lys Ser Lys Val Thr Ser Ser Glu Arg Thr Ser Ala Arg Gly Ser 
            20                  25                  30          


Asn Arg Lys Arg Leu Ile Val Glu Asp Arg Arg Val Ser Gly Thr Ser 
        35                  40                  45              


Phe Thr Ala His Arg Arg Ala Thr Ile Thr His Leu Leu Tyr Leu Cys 
    50                  55                  60                  


Pro Lys Asp Tyr Cys Pro Arg Gly Arg Val Cys Asn Ser Val Asp Pro 
65                  70                  75                  80  


Phe Val Ala His Pro Gln Asp Pro His His Pro Ser Glu Lys Pro Val 
                85                  90                  95      


Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly Glu Val Leu Arg 
            100                 105                 110         


Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr Cys Lys Val Cys 
        115                 120                 125             


Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys Asn Gly Glu Tyr 
    130                 135                 140                 


Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr Arg Cys His Gly 
145                 150                 155                 160 


Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala Leu Gly Lys Thr 
                165                 170                 175     


Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys Arg Pro Phe Pro 
            180                 185                 190         


Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys Leu Cys Gln Leu 
        195                 200                 205             


Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr Thr Phe Ser Ser 
    210                 215                 220                 


Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly Gln Ala Leu Leu 
225                 230                 235                 240 


Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys Cys Lys Ser Cys 
                245                 250                 255     


Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp Gly Ala Pro Tyr 
            260                 265                 270         


Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys Cys Glu Ala Cys 
        275                 280                 285             


His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly Asp Lys His Tyr 
    290                 295                 300                 


His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln Met Phe Thr Glu 
305                 310                 315                 320 


Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp His Pro Asp Cys 
                325                 330                 335     


Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro Thr Arg Thr Ser 
            340                 345                 350         


Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser Pro 
        355                 360                 365             


Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys 
    370                 375                 380                 


Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg 
385                 390                 395                 400 


Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp 
                405                 410                 415     


Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro 
            420                 425                 430         


Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile His 
        435                 440                 445             


Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg His 
    450                 455                 460                 


Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His Phe His Arg Pro 
465                 470                 475                 480 


Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu Pro Tyr Arg Pro 
                485                 490                 495     


Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala Pro Lys His Phe 
            500                 505                 510         


His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys Pro Pro Ile Tyr 
        515                 520                 525             


Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser Ser Glu Asp Ile 
    530                 535                 540                 


Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro Asp Pro Ser Glu 
545                 550                 555                 560 


Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro Pro Ser Phe Ala 
                565                 570                 575     


Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly Arg Glu Glu Asp 
            580                 585                 590         


Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu Glu Gln Leu Met 
        595                 600                 605             


Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys Glu Glu Met Glu 
    610                 615                 620                 


Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser Arg Tyr Asp Ser 
625                 630                 635                 640 


Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys Thr Ala Ser Leu 
                645                 650                 655     


Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val Ser Thr Asp Phe 
            660                 665                 670         


Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly Val Arg Asp Tyr 
        675                 680                 685             


Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg Met Asp Arg Gly 
    690                 695                 700                 


Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe Pro Tyr Glu Met 
705                 710                 715                 720 


Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu Arg Glu Val Asp 
                725                 730                 735     


Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val Phe Arg Glu Ile 
            740                 745                 750         


Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro Leu Trp Arg Arg 
        755                 760                 765             


Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
    770                 775             


<210>  2592
<211>  6850
<212>  DNA
<213>  Homosapiens

<400>  2592
gaggagagga ggcgtgagag agcgtgcctg cccgccgcac acggggctgg tttccggagt     60

gcgtctctag agggatgcac gttgccttag ccgagcttcg gagagaagcc tgatatgtaa    120

cccaggcagg tgggagcctc agtctgtcgg gctgaggtct ggcatctaca aagcctcttg    180

gccgtgttct gaacttgaag cctggaggag ttctctgctc agcacagcca aggaacagaa    240

ttagaagaaa aggaaccctg gcctgaggca ggtgacaaac attaccaccc cagctgtgca    300

cgatgcagca gatgcaacca gatgttcaca gaaggagagg aaatgtatct tcaaggctcc    360

accgtttggc atcccgactg taagcaatct acgaagaccg aggaaaagct gcggctgcca    420

aacattcggc gttcttcatc cgatttcttt tattccaaaa gtctgattcg acgcacagga    480

cggtctccgt ctctgcagcc taccaggaca tcctcggaaa gtatttattc taggccaggc    540

tccagtattc ctggctcacc aggtcatact atctatgcaa aagtagacaa tgagatcctg    600

gattacaagg atttagcagc cattccgaag gtcaaggcaa tttatgacat tgaacgtcca    660

gatcttatta cctatgagcc tttctacact tcgggctatg atgacaaaca ggagagacag    720

agccttggag agtctccgag gactttgtct cctactccat cagcagaagg gtaccaggat    780

gttcgggatc ggatgatcca tcggtccacg agccagggct ccatcaactc ccctgtgtac    840

agccgccaca gctacactcc aaccacgtcc cgctctcccc agcatttcca cagacctgat    900

caaggaatca acatttaccg aaagccaccc atctacaaac agcatgctgc cttggcagcc    960

cagagcaagt cctcagaaga tatcatcaag ttttccaagt tcccagcagc ccaggcacca   1020

gaccccagcg agacaccaaa gattgagacg gaccactggc ctggtccccc ctcatttgct   1080

gtcgtaggac ctgacatgaa acgcagatct agtggcagag aggaagatga tgaggaactt   1140

ctgagacgtc ggcagcttca agaagagcaa ttaatgaagc ttaactcagg cctgggacag   1200

ttgatcttga aagaagagat ggagaaagag agccgggaaa ggtcatctct gttagccagt   1260

cgctacgatt ctcccatcaa ctcagcttca catattccat catctaaaac tgcatctctc   1320

cctggctatg gaagaaatgg gcttcaccgg cctgtttcta ccgacttcgc tcagtataac   1380

agctatgggg atgtcagcgg gggagtgcga gattaccaga cactcccaga tggccacatg   1440

cctgcaatga gaatggaccg aggagtgtct atgcccaaca tgttggaacc aaagatattt   1500

ccatatgaaa tgctcatggt gaccaacaga gggcgaaaca aaatcctcag agaggtggac   1560

agaaccaggc tggagcgcca cttagcccct gaagtgtttc gggaaatctt tggaatgtcc   1620

atacaggagt ttgacaggtt acctctttgg agacgcaacg acatgaagaa aaaagcaaaa   1680

ctcttctaag tcccactcgt gaatggcaat tagagaaagg actgacagtg gcggtgcccc   1740

ataggatgtc atattgaggc ccaaacttga ttggagaatt tgcaaactac cgtcgctcag   1800

caacaccaaa aagagaaagt ctggttaaaa caccatgagt caaatgtcgg gccagccaac   1860

agtaacactt gccaagaagc atggcgtaga aatttctatg ttccgaaaca cagagtagtg   1920

tccacatgtg agcttttcac attaccttat gtatacaaca ggagctgcgt tgttttcttc   1980

tttttctttt cctttatctg ttgtccaaca acagtgctga ctgtccggat aagagctggc   2040

aagtgccctt aggatgccgc atgggaaaaa tcggttatca taatttcaaa gtataaatat   2100

atttattaag tagcgctgcg gctaagaagg aagagtgagg ggtctgtcca tggggtggca   2160

gtgatttcac acccgccttt cttgaatggc ttcgtgttac tcagccgtgc cctggcagga   2220

atggaactcc atcagggaac agggcagctc tgtttgaatg gggtgaaaaa cagcaaaatt   2280

aattcttagc aagctccttg ttctctactg ttcaccggga cctggctggc aaatgactta   2340

gctattagta tatttaaaaa ctgttcaaaa gcaaaagaga aggaacagga atgaaaggaa   2400

accttccctt aactctttct gcttcccata gcaggtctgg ttcctgctcc ccgcctagga   2460

caggagctgt ctggagctcc acctttgcaa agaaaggaaa aacacaaatt gcccccagat   2520

tggcccagtg gcatgccatt aggtgatttt gcataggggc catatcattc atggccaaaa   2580

aaaaccaaaa agcaaaaaac aaaaacaagt cccatgtcct actgactcta gttcttccag   2640

tcgttatcct ctgctgtctc tctggcatcc tatgaatcag atcaagccca tgctgttgtt   2700

ggtttttaag gtttctttca ataataggct aaggaaagac atgtttttct cttttaaatc   2760

tctgcaactc caaagtagac tccttcgaac gtatttaatt tggccttttc agctttcttc   2820

ttgcccagct ctgtcgaatt catgggtgtg tgtgcacatg ttggtttcac tcacccagag   2880

taattttgtg agcatgcatg tgctttttaa tttctgcttg aatgtttgtc ctgctgtgtt   2940

gcagcttcta aagacattgt caccgagtgt gtgtgactca aagatcaaga gtgaggctaa   3000

actgcgaccc caacatcact tccttcatgg aaaggtgttg gcgctgatgt agctcatgga   3060

aggatcagac tgggaaccac agaggaagga tgaggtggga tgtggaggtc agagcatctc   3120

acgagagtcc ctcaggctct gcaacactag attcgaatat gagcctaggg tttccccaac   3180

acgtgcgtgc atatgaaacc acatcatgat tcccgacgtg agttagatga gggagagttt   3240

gtgtaactcc acacccagga gggtaagcca ctttattatc atgctttggg gctgtgctta   3300

agaatttaag ctctgtttta aagccgaaga agaaaacatt tgaatttacc ttcatatgcc   3360

actaagaaca aaagctctga agttcttcct gctggcacca aatattagga ttacaagctg   3420

tctctctgac accagtggta aaaaagcaag tagaatagtt tctgagtctg tgttgcagcc   3480

tctgacacgt ggctcaccgc tgtcatttgg gggatggaat gaacagtcac tgttctatag   3540

catcctcctg tgctcttacc taaggaatct aaattgtcct agccttccat tgctatgcac   3600

tgaatgagga ctactctcgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt   3660

gtgtgtgttg gatctactaa catgtttagc aaatggctct gacagggtgg ccatgagcag   3720

atgagaccag ctcttgcttg gttggaagcc acactgcagt ttgcagttta gcctttggtg   3780

tctcagtggc ttcttgctta ttccatgctt tttctatccc atcctctctc tgtgccctcc   3840

tgcaatggca gccttggcac aatgcctggg tgtcctcatc cttgctttac tctggaaagt   3900

gtggggatgg agaggatggt gcatttccag tgcttcctta cctgtcaata acaatggtgg   3960

ccacctgggt cccagcactt ggctggtgga gagatttttt tcattatgga gctaataaag   4020

ggtccctacg ttttacattg attaatgaat tatcacccag acatgtgcag atgaaatgtc   4080

aatataagaa aaatcaaggt atttgggaaa catgggcata atcaggtagt tttgctaaaa   4140

ttcctcttcc ttggtctaca taaagaagac atgggtctgt catagaatgg ggacattaga   4200

ctgaaaactg ggacaacccc cttccttatt ttatagagac taggagttaa ggggcctgcc   4260

taagattgca gtgataaaga actgaaccct aaatcagctc ccactaatga aaccctgctt   4320

tccttgtatc ttttaaactc agttctgcat ccaacttgag aagaaaaaaa gcttctttcc   4380

atatcaagta ccatatgagt tcatttaaac tgcaccttgc agaaatgcat tgccagaaag   4440

caccagtagc ctcctatctg caagcagagt agtgctctgc tctggggagg ggtcattgga   4500

aaccataatg cagagtgggc cccctactcc atttcccagc aaaaggctcc agctggaggg   4560

atgggttgtg gggcaacctg gttcctgcta actgccagat tgaatgtgtg ggctagaatg   4620

cctgcacatt tagttaaact gggctcagca tgcttgtcct caaaatgtcc atcctggtca   4680

cagcacacaa gatggctatt ggtctgcttt taccctaccc tgtactatac atgaaaattc   4740

cagttattaa cacactcaaa ctggtggagc ttgttcaccc taggaagggg attgtatata   4800

tggcaggctt ccctggtgcc gatgtaaagg gctacatttg ggaacatttg acttccttgg   4860

gactcttaag tgcataatga tggcatgaag taaaaggggc ctcaatgatg ataggaaaat   4920

cagttctttt aaaatttctt caagaaaatc caggctatca catagtcttt ctgtgtgact   4980

tattaggaga taggaagagc attgggaaac ttgcacagct agctatgcat ctacattttg   5040

gtttggggtt agttatgaaa tgttcttaat atgacgtgtt caataacttc acataaactt   5100

cctgttctcc aaaacctcaa agagatagag ttaatgagtt gttgtttttt tttaaatggg   5160

ggtagttttc tatctgtcat gggctctagc atctactccg ctacccaatt ctgtcatctc   5220

caagctgagt ttcctcttct gaggcagagg ctggagcagt tctttttcag ttctcatcct   5280

ctccatccca atccagtata tcaatcaact ctaactcgga gacgtctagc tggcaatgtt   5340

tctaaaactt tcactggatt tctttagaca ttgaagcaaa catttttttc taagaattgc   5400

ttctcagatg atgatatcaa atgtatatgc ttttgcaagt ttgaaaagtt caaattaacc   5460

acttttgact aggtaagtct ttctaaaaac catttaaagc taactgggtc ttagcatcct   5520

cctgtgtatg gaagagacag gtgaccgctc caggttgggt gctcacagaa cccttttcct   5580

gactctcatg gaagatggtg gaaggaaaat agactgtctc atcaaccctc ctgtgtcctc   5640

tgaagcaatc tcagttttta ttaaccacct cttctgtgtt tctggtagct atttaacctg   5700

tatttaatct gtacttccta tgccagcctc aattttattt gatttttaca attattctct   5760

tctaaccaat gaagtgtttg tcagtatgcc ccaaagcttg ctcttttgtg ctcccttttg   5820

aataactttc tatccagaaa aagagattat ttgggacttg agatttgcag tgataccaac   5880

ttatagcaat gatgtacttt aagggaacta cccaactatg ttgtgataga agaaagagaa   5940

accttcactt tggcattttt ttttaatcac tgtttatttt tctgtttgcg gcccaggaag   6000

cagtgggagg tggtggcaga tatgctttgc atatggattg ttatgttttt atttgggcaa   6060

gtttaatcat ggaaaactca aaaagaaggg gggaaatggt cagtttaagc caaaagaaac   6120

tttctaaaca atgtataggt acacagcaaa attaaacaaa tccaacaatt tctgaagctt   6180

agtgtaattg agtggtggtt gttattcaat aaaattattc ccaaaagtgt ttctcctaag   6240

agtgcagttc ccatgagtca cttcctgaac ccattgacca aaggtggaca gagacaatcc   6300

tgtagacctt gacattcaga aagatgtgag ctgcttactg atcatatatg catacgtttc   6360

tttacagcag aggaaaccat tgtccacaaa actgatgttc ttttggggtt ttatgtacag   6420

acttgtccaa tcatgtgtgt ggttcctgcg agttgctgat gactccgcat tgaagctctc   6480

tgagttcttt gattttaagt tgggtttatg gaattttttc aaatgttgga aggtgtgtgg   6540

ttcttcctgc cctccctccc cttttggaaa tatgaaagca aatgtttaga agaattcctt   6600

ttgaaaagct gtgtcgtgtt ccctgtgaaa ctgagcaggt gtgtgttggc gcgctaagtg   6660

ccacatgctt gtgtgtagag gaggaggtgg ccctgccggc tccgcgctgc tgtgcctgtg   6720

atccctacct gctccccgct cctgttgcca gcagcactca ctgcactcct ttgtcatata   6780

ctctgcatca ctgtcatact cacaacttcg tgaataaagt tgtgtgcttt attcgtagaa   6840

aaaaaaaaaa                                                          6850


<210>  2593
<211>  455
<212>  PRT
<213>  Homosapiens

<400>  2593

Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
1               5                   10                  15      


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Leu 
            20                  25                  30          


Pro Asn Ile Arg Arg Ser Ser Ser Asp Phe Phe Tyr Ser Lys Ser Leu 
        35                  40                  45              


Ile Arg Arg Thr Gly Arg Ser Pro Ser Leu Gln Pro Thr Arg Thr Ser 
    50                  55                  60                  


Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser Pro 
65                  70                  75                  80  


Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys 
                85                  90                  95      


Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg 
            100                 105                 110         


Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp 
        115                 120                 125             


Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro 
    130                 135                 140                 


Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile His 
145                 150                 155                 160 


Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg His 
                165                 170                 175     


Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His Phe His Arg Pro 
            180                 185                 190         


Asp Gln Gly Ile Asn Ile Tyr Arg Lys Pro Pro Ile Tyr Lys Gln His 
        195                 200                 205             


Ala Ala Leu Ala Ala Gln Ser Lys Ser Ser Glu Asp Ile Ile Lys Phe 
    210                 215                 220                 


Ser Lys Phe Pro Ala Ala Gln Ala Pro Asp Pro Ser Glu Thr Pro Lys 
225                 230                 235                 240 


Ile Glu Thr Asp His Trp Pro Gly Pro Pro Ser Phe Ala Val Val Gly 
                245                 250                 255     


Pro Asp Met Lys Arg Arg Ser Ser Gly Arg Glu Glu Asp Asp Glu Glu 
            260                 265                 270         


Leu Leu Arg Arg Arg Gln Leu Gln Glu Glu Gln Leu Met Lys Leu Asn 
        275                 280                 285             


Ser Gly Leu Gly Gln Leu Ile Leu Lys Glu Glu Met Glu Lys Glu Ser 
    290                 295                 300                 


Arg Glu Arg Ser Ser Leu Leu Ala Ser Arg Tyr Asp Ser Pro Ile Asn 
305                 310                 315                 320 


Ser Ala Ser His Ile Pro Ser Ser Lys Thr Ala Ser Leu Pro Gly Tyr 
                325                 330                 335     


Gly Arg Asn Gly Leu His Arg Pro Val Ser Thr Asp Phe Ala Gln Tyr 
            340                 345                 350         


Asn Ser Tyr Gly Asp Val Ser Gly Gly Val Arg Asp Tyr Gln Thr Leu 
        355                 360                 365             


Pro Asp Gly His Met Pro Ala Met Arg Met Asp Arg Gly Val Ser Met 
    370                 375                 380                 


Pro Asn Met Leu Glu Pro Lys Ile Phe Pro Tyr Glu Met Leu Met Val 
385                 390                 395                 400 


Thr Asn Arg Gly Arg Asn Lys Ile Leu Arg Glu Val Asp Arg Thr Arg 
                405                 410                 415     


Leu Glu Arg His Leu Ala Pro Glu Val Phe Arg Glu Ile Phe Gly Met 
            420                 425                 430         


Ser Ile Gln Glu Phe Asp Arg Leu Pro Leu Trp Arg Arg Asn Asp Met 
        435                 440                 445             


Lys Lys Lys Ala Lys Leu Phe 
    450                 455 


<210>  2594
<211>  2374
<212>  DNA
<213>  Homosapiens

<400>  2594
gggtgggggg aataacatgt tcttttaaac gcagagttta aacattgagt tgcatcattg     60

tgaggaaaac cacttagtat ttttagtgag gtgactttac aagtaaagat cttcaagaag    120

atttttatgt gatttaaaaa atcagcttag atgcttggaa tttggattgt tgcattcttg    180

ttctttggca catcaagagg aaaagaagtt tgctatgaaa ggttagggtg tttcaaagat    240

ggtttaccat ggaccaggac tttctcaaca gagttggtag gtttaccctg gtctccagag    300

aagataaaca ctcgtttcct gctctacact atacacaatc ccaatgccta tcaggagatc    360

agtgcggtta attcttcaac tatccaagcc tcatattttg gaacagacaa gatcacccgt    420

atcaacatag ctggatggaa aacagatggc aaatggcaga gagacatgtg caatgtgttg    480

ctacagctgg aagatataaa ttgcattaat ttagattgga tcaacggttc acgggaatac    540

atccatgctg taaacaatct ccgtgttgtt ggtgctgagg tggcttattt tattgatgtt    600

ctcatgaaaa aatttgaata ttccccttct aaagtgcact tgattggcca cagcttggga    660

gcacacctgg ctggggaagc tgggtcaagg ataccaggcc ttggaagaat aactgggttg    720

gacccagctg ggccattttt ccacaacact ccaaaggaag tcaggctaga cccctcggat    780

gccaactttg ttgacgttat tcatacaaat gcagctcgca tcctctttga gcttggtgtt    840

ggaaccattg atgcttgtgg tcatcttgac ttttacccaa atggagggaa gcacatgcca    900

ggatgtgaag acttaattac acctttactg aaatttaact tcaatgctta caaaaaagaa    960

atggcttcct tctttgactg taaccatgcc cgaagttatc aattttatgc tgaaagcatt   1020

cttaatcctg atgcatttat tgcttatcct tgtagatcct acacatcttt taaagcagga   1080

aattgcttct tttgttccaa agaaggttgc ccaacaatgg gtcattttgc tgatagattt   1140

cacttcaaaa atatgaagac taatggatca cattattttt taaacacagg gtccctttcc   1200

ccatttgccc gttggaggca caaattgtct gttaaactca gtggaagcga agtcactcaa   1260

ggaactgtct ttcttcgtgt aggcggggca attgggaaaa ctggggagtt tgccattgtc   1320

agtggaaaac ttgagccagg catgacttac acaaaattaa tcgatgcaga tgttaacgtt   1380

ggaaacatta caagtgttca gttcatctgg aaaaaacatt tgtttgaaga ttctcagaat   1440

aagttgggag cagaaatggt gataaataca tctgggaaat atggatataa atctacctac   1500

tgtagccaag acattatggg acctaatatt ctccagaacc tgaaaccatg ctaatctcag   1560

atacagtctt gatggatttc tttagtagga gcaatgaaga aaagtgtctc cttccacctg   1620

gcatccagac caaatttgac ccttgtaaat gacttagtca tttacagggg tcttactcag   1680

agtcaagtac gggtttgctt tttttctgtg tagaatgttc atctaactgc accttaaaaa   1740

cacactgaac cctgggacaa aagataatta ctatgatctg taggaatctg gatatcattg   1800

acaaaataga gctgttttgg aattttcctg aataagagga ggtgatgcaa atgtatgttg   1860

agtgtataaa ctcactggac aaaagtaagc ctctggcttg ctgagttttt gaagtatatt   1920

ttcaggtata ataatcattg ttctaaaatt atataaaact atttgttatg ttgttaaatc   1980

ttgctgagac aaattatgac tatagtgcat gatatatagt agattataac cttgtgggtt   2040

gatgtgtcta tctagtaata ataaaaacta atgagatggc actagtattt ccaaggtgtt   2100

ccttggtgtt cagggtgtgc acaagagaga ttttggagct tatctgttat gtgttcatca   2160

gttagcaatg ggacctgaag ttcaacaacc cagggtatag cccccttcct ccaaagtccc   2220

tgccacagga gaattactcc tctctctggg tcttgaatgc tctatggtga atttgtattt   2280

agcctcaagg cagcatttca tttgtaaagc acttgggtaa ccctttgttc ttgcaataac   2340

aatattataa tatttaaaaa aaaaaaaaaa aaaa                               2374


<210>  2595
<211>  467
<212>  PRT
<213>  Homosapiens

<400>  2595

Met Leu Gly Ile Trp Ile Val Ala Phe Leu Phe Phe Gly Thr Ser Arg 
1               5                   10                  15      


Gly Lys Glu Val Cys Tyr Glu Arg Leu Gly Cys Phe Lys Asp Gly Leu 
            20                  25                  30          


Pro Trp Thr Arg Thr Phe Ser Thr Glu Leu Val Gly Leu Pro Trp Ser 
        35                  40                  45              


Pro Glu Lys Ile Asn Thr Arg Phe Leu Leu Tyr Thr Ile His Asn Pro 
    50                  55                  60                  


Asn Ala Tyr Gln Glu Ile Ser Ala Val Asn Ser Ser Thr Ile Gln Ala 
65                  70                  75                  80  


Ser Tyr Phe Gly Thr Asp Lys Ile Thr Arg Ile Asn Ile Ala Gly Trp 
                85                  90                  95      


Lys Thr Asp Gly Lys Trp Gln Arg Asp Met Cys Asn Val Leu Leu Gln 
            100                 105                 110         


Leu Glu Asp Ile Asn Cys Ile Asn Leu Asp Trp Ile Asn Gly Ser Arg 
        115                 120                 125             


Glu Tyr Ile His Ala Val Asn Asn Leu Arg Val Val Gly Ala Glu Val 
    130                 135                 140                 


Ala Tyr Phe Ile Asp Val Leu Met Lys Lys Phe Glu Tyr Ser Pro Ser 
145                 150                 155                 160 


Lys Val His Leu Ile Gly His Ser Leu Gly Ala His Leu Ala Gly Glu 
                165                 170                 175     


Ala Gly Ser Arg Ile Pro Gly Leu Gly Arg Ile Thr Gly Leu Asp Pro 
            180                 185                 190         


Ala Gly Pro Phe Phe His Asn Thr Pro Lys Glu Val Arg Leu Asp Pro 
        195                 200                 205             


Ser Asp Ala Asn Phe Val Asp Val Ile His Thr Asn Ala Ala Arg Ile 
    210                 215                 220                 


Leu Phe Glu Leu Gly Val Gly Thr Ile Asp Ala Cys Gly His Leu Asp 
225                 230                 235                 240 


Phe Tyr Pro Asn Gly Gly Lys His Met Pro Gly Cys Glu Asp Leu Ile 
                245                 250                 255     


Thr Pro Leu Leu Lys Phe Asn Phe Asn Ala Tyr Lys Lys Glu Met Ala 
            260                 265                 270         


Ser Phe Phe Asp Cys Asn His Ala Arg Ser Tyr Gln Phe Tyr Ala Glu 
        275                 280                 285             


Ser Ile Leu Asn Pro Asp Ala Phe Ile Ala Tyr Pro Cys Arg Ser Tyr 
    290                 295                 300                 


Thr Ser Phe Lys Ala Gly Asn Cys Phe Phe Cys Ser Lys Glu Gly Cys 
305                 310                 315                 320 


Pro Thr Met Gly His Phe Ala Asp Arg Phe His Phe Lys Asn Met Lys 
                325                 330                 335     


Thr Asn Gly Ser His Tyr Phe Leu Asn Thr Gly Ser Leu Ser Pro Phe 
            340                 345                 350         


Ala Arg Trp Arg His Lys Leu Ser Val Lys Leu Ser Gly Ser Glu Val 
        355                 360                 365             


Thr Gln Gly Thr Val Phe Leu Arg Val Gly Gly Ala Ile Gly Lys Thr 
    370                 375                 380                 


Gly Glu Phe Ala Ile Val Ser Gly Lys Leu Glu Pro Gly Met Thr Tyr 
385                 390                 395                 400 


Thr Lys Leu Ile Asp Ala Asp Val Asn Val Gly Asn Ile Thr Ser Val 
                405                 410                 415     


Gln Phe Ile Trp Lys Lys His Leu Phe Glu Asp Ser Gln Asn Lys Leu 
            420                 425                 430         


Gly Ala Glu Met Val Ile Asn Thr Ser Gly Lys Tyr Gly Tyr Lys Ser 
        435                 440                 445             


Thr Tyr Cys Ser Gln Asp Ile Met Gly Pro Asn Ile Leu Gln Asn Leu 
    450                 455                 460                 


Lys Pro Cys 
465         


<210>  2596
<211>  1502
<212>  DNA
<213>  Homosapiens

<400>  2596
tgttgctatc tggttgcgtg tggaacctga cggaactgcc acgatgctgc cactttggac     60

tctttcactg ctgctgggag cagtagcagg aaaagaagtt tgctacgaaa gactcggctg    120

cttcagtgat gactccccat ggtcaggaat tacggaaaga cccctccata tattgccttg    180

gtctccaaaa gatgtcaaca cccgcttcct cctatatact aatgagaacc caaacaactt    240

tcaagaagtt gccgcagatt catcaagcat cagtggctcc aatttcaaaa caaatagaaa    300

aactcgcttt attattcatg gattcataga caagggagaa gaaaactggc tggccaatgt    360

gtgcaagaat ctgttcaagg tggaaagtgt gaactgtatc tgtgtggact ggaaaggtgg    420

ctcccgaact ggatacacac aagcctcgca gaacatcagg atcgtgggag cagaagtggc    480

atattttgtt gaatttcttc agtcggcgtt cggttactca ccttccaacg tgcatgtcat    540

tggccacagc ctgggtgccc acgctgctgg ggaggctgga aggagaacca atgggaccat    600

tggacgcatc acagggttgg acccagcaga accttgcttt cagggcacac ctgaattagt    660

ccgattggac cccagcgatg ccaaatttgt ggatgtaatt cacacggatg gtgcccccat    720

agtccccaat ttggggtttg gaatgagcca agtcgtgggc cacctagatt tctttccaaa    780

tggaggagtg gaaatgcctg gatgtaaaaa gaacattctc tctcagattg tggacataga    840

cggaatctgg gaagggactc gagactttgc ggcctgtaat cacttaagaa gctacaaata    900

ttacactgat agcatcgtca accctgatgg ctttgctgga ttcccctgtg cctcttacaa    960

cgtcttcact gcaaacaagt gtttcccttg tccaagtgga ggctgcccac agatgggtca   1020

ctatgctgat agatatcctg ggaaaacaaa tgatgtgggc cagaaatttt atctagacac   1080

tggtgatgcc agtaattttg cacgttggag gtataaggta tctgtcacac tgtctggaaa   1140

aaaggttaca ggacacatac tagtttcttt gttcggaaat aaaggaaact ctaagcagta   1200

tgaaattttc aagggcactc tcaaaccaga tagtactcat tccaatgaat ttgactcaga   1260

tgtggatgtt ggggacttgc agatggttaa atttatttgg tataacaatg tgatcaaccc   1320

aactttacct agagtgggag catccaagat tatagtggag acaaatgttg gaaaacagtt   1380

caacttctgt agtccagaaa ccgtcaggga ggaagttctg ctcaccctca caccgtgtta   1440

ggagactact gttatttgac caatgaattg acttctaata aaatctagtg gtgatgcaaa   1500

aa                                                                  1502


<210>  2597
<211>  465
<212>  PRT
<213>  Homosapiens

<400>  2597

Met Leu Pro Leu Trp Thr Leu Ser Leu Leu Leu Gly Ala Val Ala Gly 
1               5                   10                  15      


Lys Glu Val Cys Tyr Glu Arg Leu Gly Cys Phe Ser Asp Asp Ser Pro 
            20                  25                  30          


Trp Ser Gly Ile Thr Glu Arg Pro Leu His Ile Leu Pro Trp Ser Pro 
        35                  40                  45              


Lys Asp Val Asn Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro Asn 
    50                  55                  60                  


Asn Phe Gln Glu Val Ala Ala Asp Ser Ser Ser Ile Ser Gly Ser Asn 
65                  70                  75                  80  


Phe Lys Thr Asn Arg Lys Thr Arg Phe Ile Ile His Gly Phe Ile Asp 
                85                  90                  95      


Lys Gly Glu Glu Asn Trp Leu Ala Asn Val Cys Lys Asn Leu Phe Lys 
            100                 105                 110         


Val Glu Ser Val Asn Cys Ile Cys Val Asp Trp Lys Gly Gly Ser Arg 
        115                 120                 125             


Thr Gly Tyr Thr Gln Ala Ser Gln Asn Ile Arg Ile Val Gly Ala Glu 
    130                 135                 140                 


Val Ala Tyr Phe Val Glu Phe Leu Gln Ser Ala Phe Gly Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Val His Val Ile Gly His Ser Leu Gly Ala His Ala Ala Gly 
                165                 170                 175     


Glu Ala Gly Arg Arg Thr Asn Gly Thr Ile Gly Arg Ile Thr Gly Leu 
            180                 185                 190         


Asp Pro Ala Glu Pro Cys Phe Gln Gly Thr Pro Glu Leu Val Arg Leu 
        195                 200                 205             


Asp Pro Ser Asp Ala Lys Phe Val Asp Val Ile His Thr Asp Gly Ala 
    210                 215                 220                 


Pro Ile Val Pro Asn Leu Gly Phe Gly Met Ser Gln Val Val Gly His 
225                 230                 235                 240 


Leu Asp Phe Phe Pro Asn Gly Gly Val Glu Met Pro Gly Cys Lys Lys 
                245                 250                 255     


Asn Ile Leu Ser Gln Ile Val Asp Ile Asp Gly Ile Trp Glu Gly Thr 
            260                 265                 270         


Arg Asp Phe Ala Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr Thr 
        275                 280                 285             


Asp Ser Ile Val Asn Pro Asp Gly Phe Ala Gly Phe Pro Cys Ala Ser 
    290                 295                 300                 


Tyr Asn Val Phe Thr Ala Asn Lys Cys Phe Pro Cys Pro Ser Gly Gly 
305                 310                 315                 320 


Cys Pro Gln Met Gly His Tyr Ala Asp Arg Tyr Pro Gly Lys Thr Asn 
                325                 330                 335     


Asp Val Gly Gln Lys Phe Tyr Leu Asp Thr Gly Asp Ala Ser Asn Phe 
            340                 345                 350         


Ala Arg Trp Arg Tyr Lys Val Ser Val Thr Leu Ser Gly Lys Lys Val 
        355                 360                 365             


Thr Gly His Ile Leu Val Ser Leu Phe Gly Asn Lys Gly Asn Ser Lys 
    370                 375                 380                 


Gln Tyr Glu Ile Phe Lys Gly Thr Leu Lys Pro Asp Ser Thr His Ser 
385                 390                 395                 400 


Asn Glu Phe Asp Ser Asp Val Asp Val Gly Asp Leu Gln Met Val Lys 
                405                 410                 415     


Phe Ile Trp Tyr Asn Asn Val Ile Asn Pro Thr Leu Pro Arg Val Gly 
            420                 425                 430         


Ala Ser Lys Ile Ile Val Glu Thr Asn Val Gly Lys Gln Phe Asn Phe 
        435                 440                 445             


Cys Ser Pro Glu Thr Val Arg Glu Glu Val Leu Leu Thr Leu Thr Pro 
    450                 455                 460                 


Cys 
465 


<210>  2598
<211>  1481
<212>  DNA
<213>  Homosapiens

<400>  2598
ctctggaaca ttagacagga tgctgatctt ctggacaatc acacttttcc tgctgggagc     60

agccaaagga aaagaagttt gctatgagga cctcgggtgc ttttctgaca ctgagccctg    120

gggcgggaca gcaatcaggc ccctgaaaat tctcccctgg agccctgaga agatcggcac    180

ccgcttcctg ctgtacacca atgaaaaccc aaacaacttt caaattctcc tcctctctga    240

tccatcaaca attgaggcat caaattttca aatggacaga aagacccggt tcatcatcca    300

tggcttcata gacaaaggag atgagagctg ggtgacagac atgtgcaaga aactgttcga    360

ggtggaggag gtgaactgca tctgcgtgga ctggaagaag ggctcccaag ccacctacac    420

acaggctgcc aacaacgtgc gagtggtggg cgcccaggtg gcccagatgc tcgacatcct    480

cttgacagag tatagctacc ccccttccaa agttcacctc attggccaca gcctgggagc    540

ccacgtggct ggagaggcag gaagcaagac tccaggcctg agcaggatta cagggttgga    600

tcctgtagaa gcaagtttcg agagtactcc tgaagaggtg cgacttgatc cctctgatgc    660

tgactttgtt gatgtgattc acacggatgc agctcccctg atcccattct tgggttttgg    720

aacgaaccaa cagatgggtc atcttgactt cttccccaat ggaggagaga gcatgccggg    780

atgcaagaag aatgccctgt ctcagatcgt ggatctagat ggcatctggg cgggaacccg    840

ggactttgtg gcttgcaatc acctaagaag ctacaagtat tacttggaaa gcatcctcaa    900

tcccgatggg tttgctgcat atccctgcac ttcctacaag tcctttgagt ctgacaagtg    960

cttcccgtgt ccagatcaag gatgcccaca gatgggtcac tatgctgata aatttgctgg   1020

caggacaagt gaagagcagc agaaattctt cttgaacaca ggagaggcta gcaatttcgc   1080

tcgctggaga tatggggttt ccatcacact gtctggaaga acagccactg gtcagatcaa   1140

agttgctttg tttggaaata agggaaacac tcaccagtac agcatcttca gggggattct   1200

caaaccaggc tcaacccatt cctatgagtt tgatgcaaag ctggatgttg gaacaattga   1260

gaaagtcaag tttctttgga ataacaatgt gataaatcca accctcccca aagtgggtgc   1320

caccaagatc actgtgcaaa agggagaaga gaagacagtg tacaacttct gtagcgaaga   1380

cacagtgcgg gaagacacgc tgctcaccct cacgccctgc taagctcccg gggcgacgag   1440

gctgctgcgt tcacactaat aaaatccact ggtgcatctg t                       1481


<210>  2599
<211>  467
<212>  PRT
<213>  Homosapiens

<400>  2599

Met Leu Ile Phe Trp Thr Ile Thr Leu Phe Leu Leu Gly Ala Ala Lys 
1               5                   10                  15      


Gly Lys Glu Val Cys Tyr Glu Asp Leu Gly Cys Phe Ser Asp Thr Glu 
            20                  25                  30          


Pro Trp Gly Gly Thr Ala Ile Arg Pro Leu Lys Ile Leu Pro Trp Ser 
        35                  40                  45              


Pro Glu Lys Ile Gly Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro 
    50                  55                  60                  


Asn Asn Phe Gln Ile Leu Leu Leu Ser Asp Pro Ser Thr Ile Glu Ala 
65                  70                  75                  80  


Ser Asn Phe Gln Met Asp Arg Lys Thr Arg Phe Ile Ile His Gly Phe 
                85                  90                  95      


Ile Asp Lys Gly Asp Glu Ser Trp Val Thr Asp Met Cys Lys Lys Leu 
            100                 105                 110         


Phe Glu Val Glu Glu Val Asn Cys Ile Cys Val Asp Trp Lys Lys Gly 
        115                 120                 125             


Ser Gln Ala Thr Tyr Thr Gln Ala Ala Asn Asn Val Arg Val Val Gly 
    130                 135                 140                 


Ala Gln Val Ala Gln Met Leu Asp Ile Leu Leu Thr Glu Tyr Ser Tyr 
145                 150                 155                 160 


Pro Pro Ser Lys Val His Leu Ile Gly His Ser Leu Gly Ala His Val 
                165                 170                 175     


Ala Gly Glu Ala Gly Ser Lys Thr Pro Gly Leu Ser Arg Ile Thr Gly 
            180                 185                 190         


Leu Asp Pro Val Glu Ala Ser Phe Glu Ser Thr Pro Glu Glu Val Arg 
        195                 200                 205             


Leu Asp Pro Ser Asp Ala Asp Phe Val Asp Val Ile His Thr Asp Ala 
    210                 215                 220                 


Ala Pro Leu Ile Pro Phe Leu Gly Phe Gly Thr Asn Gln Gln Met Gly 
225                 230                 235                 240 


His Leu Asp Phe Phe Pro Asn Gly Gly Glu Ser Met Pro Gly Cys Lys 
                245                 250                 255     


Lys Asn Ala Leu Ser Gln Ile Val Asp Leu Asp Gly Ile Trp Ala Gly 
            260                 265                 270         


Thr Arg Asp Phe Val Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr 
        275                 280                 285             


Leu Glu Ser Ile Leu Asn Pro Asp Gly Phe Ala Ala Tyr Pro Cys Thr 
    290                 295                 300                 


Ser Tyr Lys Ser Phe Glu Ser Asp Lys Cys Phe Pro Cys Pro Asp Gln 
305                 310                 315                 320 


Gly Cys Pro Gln Met Gly His Tyr Ala Asp Lys Phe Ala Gly Arg Thr 
                325                 330                 335     


Ser Glu Glu Gln Gln Lys Phe Phe Leu Asn Thr Gly Glu Ala Ser Asn 
            340                 345                 350         


Phe Ala Arg Trp Arg Tyr Gly Val Ser Ile Thr Leu Ser Gly Arg Thr 
        355                 360                 365             


Ala Thr Gly Gln Ile Lys Val Ala Leu Phe Gly Asn Lys Gly Asn Thr 
    370                 375                 380                 


His Gln Tyr Ser Ile Phe Arg Gly Ile Leu Lys Pro Gly Ser Thr His 
385                 390                 395                 400 


Ser Tyr Glu Phe Asp Ala Lys Leu Asp Val Gly Thr Ile Glu Lys Val 
                405                 410                 415     


Lys Phe Leu Trp Asn Asn Asn Val Ile Asn Pro Thr Leu Pro Lys Val 
            420                 425                 430         


Gly Ala Thr Lys Ile Thr Val Gln Lys Gly Glu Glu Lys Thr Val Tyr 
        435                 440                 445             


Asn Phe Cys Ser Glu Asp Thr Val Arg Glu Asp Thr Leu Leu Thr Leu 
    450                 455                 460                 


Thr Pro Cys 
465         


<210>  2600
<211>  1486
<212>  DNA
<213>  Homosapiens

<400>  2600
gtgagtggaa gctctggtgc agcatgatgc tgcccccttg gaccctcggc cttctcctgc     60

tggccacagt cagaggaaaa gaggtctgct acggacaact tggctgcttt tctgatgaaa    120

aaccatgggc aggaaccctt cagcgacctg taaaattact tccctggtcc cccgaggaca    180

ttgacacccg ctttcttctg tacacaaatg aaaatccaaa caacttccaa ctaatcactg    240

gcacggaacc agacaccatt gaggcttcaa acttccaact ggaccgcaag acacgcttca    300

tcatccatgg cttcttagac aaggcggagg acagctggcc atcggacatg tgcaagaaaa    360

tgtttgaagt ggagaaggtg aactgcatct gtgtggactg gaggcacggg tcccgggcaa    420

tgtacaccca agccgtgcaa aacattcggg ttgttggggc ggagacagct ttcttaatac    480

aagcactgtc gacgcagcta gggtacagcc ttgaggacgt gcatgtcatc ggccacagcc    540

tgggcgcgca cacggccgcg gaggcgggca ggaggctggg gggccgcgtg ggcaggatca    600

cagggctgga tccagcaggg ccgtgcttcc aggatgaacc tgaggaggtt cggttggatc    660

catctgacgc cgtgtttgtg gatgtgattc acacagattc ttctcccata gttccttccc    720

taggtttcgg aatgagccaa aaggtgggcc atctggattt ctttccaaat ggaggaaagg    780

aaatgcccgg atgtaagaaa aatgtccttt caaccattac tgatattgat ggaatatggg    840

aaggaattgg tggctttgtg tcttgcaatc acctaagaag cttcgagtat tactcaagca    900

gcgtcctcaa ccctgatggc ttcctgggct atccctgtgc ctcctacgat gagtttcagg    960

agagtaagtg tttcccttgt ccagctgaag gatgccccaa aatggggcac tatgctgacc   1020

aatttaaggg gaaaacaagt gctgtggaac aaaccttttt cctgaacaca ggagagagtg   1080

gtaactttac tagttggaga tataaggtat cagtcacact ttctggaaaa gagaaagtga   1140

atgggtacat caggattgct ttgtatggaa gtaatgaaaa ctcaaaacaa tatgagattt   1200

tcaaaggatc cctcaaacca gatgcaagtc acacgtgtgc tattgatgtg gattttaatg   1260

ttggaaaaat acagaaagtt aaattcctct ggaacaaacg tgggataaat ctatctgagc   1320

ccaaactggg ggcttcccaa atcacagtgc aaagtggtga agatgggact gagtataatt   1380

tttgtagcag cgacactgtg gaagaaaacg tcttgcaatc tctttaccct tgttaaaaac   1440

gtggtgcagc tattgcggta ataaaatctt taatgcactc ggaaaa                  1486


<210>  2601
<211>  470
<212>  PRT
<213>  Homosapiens

<400>  2601

Met Met Leu Pro Pro Trp Thr Leu Gly Leu Leu Leu Leu Ala Thr Val 
1               5                   10                  15      


Arg Gly Lys Glu Val Cys Tyr Gly Gln Leu Gly Cys Phe Ser Asp Glu 
            20                  25                  30          


Lys Pro Trp Ala Gly Thr Leu Gln Arg Pro Val Lys Leu Leu Pro Trp 
        35                  40                  45              


Ser Pro Glu Asp Ile Asp Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn 
    50                  55                  60                  


Pro Asn Asn Phe Gln Leu Ile Thr Gly Thr Glu Pro Asp Thr Ile Glu 
65                  70                  75                  80  


Ala Ser Asn Phe Gln Leu Asp Arg Lys Thr Arg Phe Ile Ile His Gly 
                85                  90                  95      


Phe Leu Asp Lys Ala Glu Asp Ser Trp Pro Ser Asp Met Cys Lys Lys 
            100                 105                 110         


Met Phe Glu Val Glu Lys Val Asn Cys Ile Cys Val Asp Trp Arg His 
        115                 120                 125             


Gly Ser Arg Ala Met Tyr Thr Gln Ala Val Gln Asn Ile Arg Val Val 
    130                 135                 140                 


Gly Ala Glu Thr Ala Phe Leu Ile Gln Ala Leu Ser Thr Gln Leu Gly 
145                 150                 155                 160 


Tyr Ser Leu Glu Asp Val His Val Ile Gly His Ser Leu Gly Ala His 
                165                 170                 175     


Thr Ala Ala Glu Ala Gly Arg Arg Leu Gly Gly Arg Val Gly Arg Ile 
            180                 185                 190         


Thr Gly Leu Asp Pro Ala Gly Pro Cys Phe Gln Asp Glu Pro Glu Glu 
        195                 200                 205             


Val Arg Leu Asp Pro Ser Asp Ala Val Phe Val Asp Val Ile His Thr 
    210                 215                 220                 


Asp Ser Ser Pro Ile Val Pro Ser Leu Gly Phe Gly Met Ser Gln Lys 
225                 230                 235                 240 


Val Gly His Leu Asp Phe Phe Pro Asn Gly Gly Lys Glu Met Pro Gly 
                245                 250                 255     


Cys Lys Lys Asn Val Leu Ser Thr Ile Thr Asp Ile Asp Gly Ile Trp 
            260                 265                 270         


Glu Gly Ile Gly Gly Phe Val Ser Cys Asn His Leu Arg Ser Phe Glu 
        275                 280                 285             


Tyr Tyr Ser Ser Ser Val Leu Asn Pro Asp Gly Phe Leu Gly Tyr Pro 
    290                 295                 300                 


Cys Ala Ser Tyr Asp Glu Phe Gln Glu Ser Lys Cys Phe Pro Cys Pro 
305                 310                 315                 320 


Ala Glu Gly Cys Pro Lys Met Gly His Tyr Ala Asp Gln Phe Lys Gly 
                325                 330                 335     


Lys Thr Ser Ala Val Glu Gln Thr Phe Phe Leu Asn Thr Gly Glu Ser 
            340                 345                 350         


Gly Asn Phe Thr Ser Trp Arg Tyr Lys Val Ser Val Thr Leu Ser Gly 
        355                 360                 365             


Lys Glu Lys Val Asn Gly Tyr Ile Arg Ile Ala Leu Tyr Gly Ser Asn 
    370                 375                 380                 


Glu Asn Ser Lys Gln Tyr Glu Ile Phe Lys Gly Ser Leu Lys Pro Asp 
385                 390                 395                 400 


Ala Ser His Thr Cys Ala Ile Asp Val Asp Phe Asn Val Gly Lys Ile 
                405                 410                 415     


Gln Lys Val Lys Phe Leu Trp Asn Lys Arg Gly Ile Asn Leu Ser Glu 
            420                 425                 430         


Pro Lys Leu Gly Ala Ser Gln Ile Thr Val Gln Ser Gly Glu Asp Gly 
        435                 440                 445             


Thr Glu Tyr Asn Phe Cys Ser Ser Asp Thr Val Glu Glu Asn Val Leu 
    450                 455                 460                 


Gln Ser Leu Tyr Pro Cys 
465                 470 


<210>  2602
<211>  1009
<212>  DNA
<213>  Homosapiens

<400>  2602
gggcagaggc caagtgggca ccggatagcg ccagccccgc ccagagagcg aaatcatgga     60

gccttccaag accttcatga gaaacctgcc aatcacacca ggctatagcg gctttgtgcc    120

attcctcagc tgccaaggaa tgtccaagga ggatgacatg aaccactgtg tgaaaacctt    180

ccaggagaaa acacagcgct ataaagaaca gctgcgggaa ttgtgctgcg cagtggccac    240

tgccccgaaa ctgaaacctg tcaactccga ggagacggtc ctgcaggccc tgcaccagta    300

caatctgcag taccaccccc tgatcctgga atgcaaatat gtaaagaaac ctctccagga    360

gcccccgatc cctggctggg caggctacct gccgagagcc aaggtcactg aatttggctg    420

tggcacgaga tacactgtca tggccaaaaa ctgctacaag gacttcctgg agatcacgga    480

gagggccaag aaggcacatc tgaaaccata tgaagagtga ggagaaatgt ctctttcctt    540

cctactaccg ttttaaaaag gggatgaaat gtttgcagtg gcctttctgc ttagctgggc    600

cagctccctg caactcacac ggacggttcc tctcctagat ggaagctgcc ctgcccttgg    660

aaggcccctg agagaggacc ccaaaactcc gctgacatgt ggctgtgctc agaggccaag    720

tataccatgc agtgggaaga tgtatctaga gccactgtcc tccgcaaagt atgcagaagg    780

ctagaagcgc agagtctccc aaggaggtga actttaagtg gggcttccaa aacctgccat    840

tctcatgttg gaatcacgcc cagtgagcaa taaagaaatt tagtaacaag aattttttaa    900

ctgccgcctg catcctgagt ggttgacggt tgcatgtcat taatgataaa gaccgttttt    960

tgtcatgtgg gaataaagag gctgcttctc cgcaaaaaaa aaaaaaaaa               1009


<210>  2603
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  2603

Met Glu Pro Ser Lys Thr Phe Met Arg Asn Leu Pro Ile Thr Pro Gly 
1               5                   10                  15      


Tyr Ser Gly Phe Val Pro Phe Leu Ser Cys Gln Gly Met Ser Lys Glu 
            20                  25                  30          


Asp Asp Met Asn His Cys Val Lys Thr Phe Gln Glu Lys Thr Gln Arg 
        35                  40                  45              


Tyr Lys Glu Gln Leu Arg Glu Leu Cys Cys Ala Val Ala Thr Ala Pro 
    50                  55                  60                  


Lys Leu Lys Pro Val Asn Ser Glu Glu Thr Val Leu Gln Ala Leu His 
65                  70                  75                  80  


Gln Tyr Asn Leu Gln Tyr His Pro Leu Ile Leu Glu Cys Lys Tyr Val 
                85                  90                  95      


Lys Lys Pro Leu Gln Glu Pro Pro Ile Pro Gly Trp Ala Gly Tyr Leu 
            100                 105                 110         


Pro Arg Ala Lys Val Thr Glu Phe Gly Cys Gly Thr Arg Tyr Thr Val 
        115                 120                 125             


Met Ala Lys Asn Cys Tyr Lys Asp Phe Leu Glu Ile Thr Glu Arg Ala 
    130                 135                 140                 


Lys Lys Ala His Leu Lys Pro Tyr Glu Glu 
145                 150                 


<210>  2604
<211>  6355
<212>  DNA
<213>  Homosapiens

<400>  2604
atgaatcatt cacaactgaa gccttgcatt attaatatcg ttattctcag acttctaagg     60

agggcccagc tggatcccat atatggaagg cgcgactcag cctccggggc aagcacctcc    120

ctgggtccgg agttgccatg gagtcccgca ggcggcctgg aggcggtgcc ccgggctcgg    180

cccccgcgca ggtccttggt ctgcggcctg ggtcctgccc gcgccggggt ccacccagcc    240

cgcctttgcg ccggcccagg gccgctcccc tgggaccctg ggggacagac agaagctggt    300

ggggactggc gcgggcgtcc tcgggagagc gccgggcgcg ctgggcttgc tgaagggctc    360

caggcctggc cattcggtga cttccaaaga ggggacgcgc cgcggggccc cgagggcctg    420

aaatccgctc ccgcagcgca gccccgggcg cgccactacc cccgccgcgg tcgactgcgg    480

ggcgaccgct cggtcccgaa gccgggagag gagaggccgg gcctcggcgg gccgctctgg    540

gcgggcgggg agcgcagctc cggagccagg cagttccccg cgcccgcctt ccccgacctt    600

tcccggccgg cccgagctcg gagggcgctc ccgctgcccg gcggctcaga cacggcccga    660

gcgccgccgc ggacgcggac agagacccgc acgggcacgg gcgctgcgct ggaggctccc    720

ctcgcggtcc ggggctgcgc gaccatggcg gacaaggagg ccggcggcag cgacgggccc    780

cgagaaacgg ctcccacatc tgcatattca tctccagccc ggagtcttgg ggacacagga    840

ataacgcctc tgtccccctc ccatattgtg aacgacactg actccaacgt ctcagaacag    900

cagtcatttc tcgtggtggt ggccgtcgac tttgggacca catccagtgg ctatgcctac    960

agcttcacca aggagccgga atgcatccat gtgatgaggc gatgggaggg aggtgaccct   1020

ggtgtgtcca atcagaagac tccaaccacc atcttgctga ctcccgagag gaagttccac   1080

agcttcgggt atgccgccag ggacttttac catgacctgg atcccaatga ggccaagcag   1140

tggctgtacc tggagaagtt caagatgaag ctgcacacca ctggggacct caccatggat   1200

acagacctga cggcagcaaa tggcaagaaa gtcaaagccc ttgaaatctt tgcttatgcc   1260

ctgcagtact ttaaggagca ggcgctgaag gagctgagtg accaggcggg ttcggagttc   1320

gagaactctg atgtcagatg ggtcatcacg gtgcctgcca tctggaagca gccggccaag   1380

cagttcatga gacaagctgc ctaccaggca ggcctggcct cccccgagaa ctcggagcag   1440

ctcatcattg ccttggagcc tgaggcagcc tctatctact gccgaaagct gcggctacac   1500

cagatgattg agctgagcag caaggcagcc gtcaatgggt acagcggcag tgacacagta   1560

ggagctgggt ttacacaggc taaggaacac atacggcgta atcggcagag tcggaccttt   1620

ttggtggaga atgtcatagg agaaatctgg tccgagctgg aggaaggtga taagtatgtg   1680

gttgtggaca gtggcggtgg caccgtagac ctgacagtcc atcagatccg gttaccggag   1740

ggacacctta aggaactgta taaagcaaca ggcggaccct atggatcttt aggagtagat   1800

tatgagttcg aaaaacttct gtataaaata tttggagagg attttattga acaattcaaa   1860

atcaaacgcc ctgcagcctg ggttgactta atgattgcgt ttgagtctcg caaaagggcg   1920

gctgccccag acagaactaa cccgctgaac atcaccctgc ccttctcctt cattgactac   1980

tacaagaagt tccgcgggca cagtgtggag cacgccttgc ggaaaagcaa tgtggatttt   2040

gtgaagtggt cctcgcaggg gatgctgcgg atgagtccag atgccatgaa cgcccttttt   2100

aagccgacca tcgatagcat cattgagcat ctccgggacc tgtttcagaa gcccgaggtg   2160

tccaccgtca agttcctctt tctggtgggc ggctttgccg aggcgcccct gctgcagcag   2220

gcggtgcagg ctgcttttgg ggaccagtgc cggatcatca tcccccagga cgtgggcctc   2280

accatcctca agggtgccgt cctctttggc ctggaccccg cggtcatcaa ggtgcgccgg   2340

tcgccgctca cctacggggt aggcgtgctg aaccgctacg tggagggcaa gcacccgcct   2400

gagaagctgc tggtgaagga tggcactcgg tggtgcaccg acgtctttga caagttcatc   2460

tctgccgacc agtctgtggc tctgggtgag ctggtcaagc gtagctacac cccggccaag   2520

ccctcccagc tggtcattgt catcaacatc tacagctctg agcacgacaa cgtcagcttc   2580

atcactgatc ccggggtgaa gaagtgtggc acgctccgcc tggatctcac agggaccagt   2640

ggcactgcgg tgcccgcccg gagggagatc cagaccctta tgcagttcgg ggacaccgag   2700

atcaaagcca cagccattga tatagccact tcgaagagtg tcaaagttgg gatcgacttc   2760

ttaaattact aaccctcccg ccccgctgcc tgtccccttg gactcaactt atctgcatct   2820

gctgacctca accttgactg ttctttccct aaccttgacc ctcaccattg cccatgtgaa   2880

tttcagcagg gaagatgaga acaatcaggg ctagaaataa ttagtgactt ttgagggcac   2940

actggagtca gaaaaacaga aattaagatt aaggtttagg catagaaaat taaaggatcc   3000

tggaggagca gctagttttc ataggtacaa aagtggtgaa atggccacgg agaagggaat   3060

cagtacattt ctgcagcagt ggttgcgctg ctttgaacag atctccgtta tgtagaattt   3120

aggatgccct attgctgtct ttctagattt aaaatgagat ctttgaacca ggaggagatc   3180

ttcatctgag acttgtcttt ctaaattttt tggatggcca tcaatataaa atgccaccca   3240

tctgcagtta atttcttttc ctcatcatgt gattaaaagt ggtgattcag tgggaactgg   3300

gaatgttttt agctggtggt agaaggctgc ctacactggg cactgtttta gattctcata   3360

tcatttaaac agcaaggagg ttcagggaag aataaccgta gccttgggta atccactagg   3420

gcttttgtga gtaggagagc tgatacctca cattcttagc aggtgaaaac ttgccatgat   3480

ggaaacagat agtgaagagt tactgacgta tcccaaatta tatgctgtga cataaattcc   3540

cagcatgccc agccctgatt tctgagttca taagtaattc tagtgaacct tagtaggaat   3600

tctgggtaag aaaatgaggt tgccattggt cttgtttgca tcaccaagac cagacatcca   3660

gaagagcccc tcaccttgaa aagcagacag attttaaatt aaccccctcc ttcccactca   3720

ccttcatctc cctaagagtt ttggccattt aattccacat tttgaaagga atacattggt   3780

gaaatttggg aagagaatct gtgctatgca atgtttcatt aaaatcttca gtttttcaag   3840

tctctctaaa aataatttgt agatctatac ttgatgtatt aagtcagttt tttttcacag   3900

cgggcctgtg gctcgcctgc atcagaattg cctgggtgcg tgttcagaac aggttcctgg   3960

atctgagccc tttttaactg aggccgactc ttggagaggg gcaccagaat ctgcatttgt   4020

agtgtatacc acatcgtggt tcaactgaaa ttggagaaat actaacctga gattttgttg   4080

aagttcacac acagatcaca gcccgccctc tgcaggtgtc ccctttgggc tcctttagga   4140

agagggcttc catgagaagg tgaccccata ccttgccctc ttggtcaatg ggattggggc   4200

tccacctggc ttggagatgg cccttttaac cctcacagga agggccaggg gaggaaaaaa   4260

attgcaagaa agcgacacca agaacggagc tgactgagga accaactgga gggtcttcac   4320

tctctccttc cccagtgtac aaaaccagtt ttctgcaaca ttcaggagcc aaatgaggaa   4380

aaagaatcaa gaatctgact cacagcccat ctgatctgtt caaagctgtc ttttccacct   4440

gctgaaattc attaaatcac tggaggcatg cataatgaat ggagaatgag tgaacttcca   4500

atgcaacttg gattcacaaa cccattatca tagccaatat gcagatttta aacagcattt   4560

cacatttcat ttgaccatgt cttctttttc gcatcgcctg ctgcagaatt ccctactaga   4620

atgtgaaaca acgaacaaac cacagaactt agagtgtgct ggttagtcac ataacttagt   4680

agcaggattg tgtatccagg cacaaaggtg tctttgctaa tgttctcttg ctacctgccc   4740

tgcttcaaac gctaaatggt atgggtcttt ctttgttgcc agccatattc tacaaataag   4800

acttttcaat atagttatga gtaatataat tttatgtaca tataatgtta gaatattgta   4860

cagaatcttg gtttctacga tgcgcttttc ttgtttcaaa aagaggaaaa tgcttgattt   4920

ttgttgatga tacttttgtt actgtcctta attttccata gtttggtttc ttaattgtgc   4980

tcactaagca tcgatctgtg ctgatgccaa gctatggact atgtacgcaa gaccgagcaa   5040

tagacagagg tgcctagggt ccaaacacac tgaacgcacg tggaccgcct ggatcaggag   5100

cctcatcaga cccttctcca tgcacatcct tcccaaacag tcacagattc cattgaaagg   5160

agcagattct atcagttctt ctgtgcagac tttaagagct gaacgttctg gttctggaag   5220

ccatgtgact gcgcagaaca acctaagaaa ccctttgtgt cctgaggggt cgttgacctc   5280

tccttccggg tcggagcagt cactctgagg gcaaagcgtg gtccactgtg tgtgatgttt   5340

tcaggatgct agggtcaaag aaagaaacca agtggtacat aagcccagct tttctgctgg   5400

gctaagtgta agtgtgagta acatggtcaa gcccctcttt tttgggctaa tgtaaagcct   5460

ttcctgcctt gcattaatgc tatctccctg tgtactgttt ctcttaaatg agcagataga   5520

aatctgcagt gttggcagat aggtgatgga gaggatgata attttatctt ctggccacag   5580

agctgcagcc ccagttgtca gagtccttaa atgaaacccc caaatccatc cctccttccc   5640

tacccccact ggaatattct agaataagag cactggataa gtacacttga acacattttt   5700

ctaaccttag aaaataccta caaggcctgt tgtcttgacc cattactcaa ttgtccctgg   5760

catattatct gatcttcacg tttcttggaa gcagaatcat caaggctttc ctttgtaact   5820

gccctttccg tacacagcag gcatgaataa atgctgagta acagacaagt tacagacagg   5880

aggggaaaga ggaggaacca tacaactgtt tttgcaaaat gatggctgag tccagattat   5940

agaggttgcc ttacccttag aatgttattt agaccaagtt tagcttttag agtccaggtc   6000

tggttaattg ccagggtagc aaagaatcgc atgcaccaat gtaaacagga gtcagaatgc   6060

attattagtc aaagatcgaa tttcacattg tagagatgta tagctgtgat taagctgcat   6120

atgtatgctg ggaaacggct tgagtggatg gctaatataa aagttgttgg ccataatgcc   6180

acacctctca tctgcttgaa atatggacca gtattctaaa atatcagcta ctggggtctc   6240

attcactaca agataaattc aaacttcaca gaactttgca gcagttcacc accagacggg   6300

actgtgtctg caaactctct tgtcttcaca gacgcctaat aaagcaaaac tctga        6355


<210>  2605
<211>  923
<212>  PRT
<213>  Homosapiens

<400>  2605

Met Asn His Ser Gln Leu Lys Pro Cys Ile Ile Asn Ile Val Ile Leu 
1               5                   10                  15      


Arg Leu Leu Arg Arg Ala Gln Leu Asp Pro Ile Tyr Gly Arg Arg Asp 
            20                  25                  30          


Ser Ala Ser Gly Ala Ser Thr Ser Leu Gly Pro Glu Leu Pro Trp Ser 
        35                  40                  45              


Pro Ala Gly Gly Leu Glu Ala Val Pro Arg Ala Arg Pro Pro Arg Arg 
    50                  55                  60                  


Ser Leu Val Cys Gly Leu Gly Pro Ala Arg Ala Gly Val His Pro Ala 
65                  70                  75                  80  


Arg Leu Cys Ala Gly Pro Gly Pro Leu Pro Trp Asp Pro Gly Gly Gln 
                85                  90                  95      


Thr Glu Ala Gly Gly Asp Trp Arg Gly Arg Pro Arg Glu Ser Ala Gly 
            100                 105                 110         


Arg Ala Gly Leu Ala Glu Gly Leu Gln Ala Trp Pro Phe Gly Asp Phe 
        115                 120                 125             


Gln Arg Gly Asp Ala Pro Arg Gly Pro Glu Gly Leu Lys Ser Ala Pro 
    130                 135                 140                 


Ala Ala Gln Pro Arg Ala Arg His Tyr Pro Arg Arg Gly Arg Leu Arg 
145                 150                 155                 160 


Gly Asp Arg Ser Val Pro Lys Pro Gly Glu Glu Arg Pro Gly Leu Gly 
                165                 170                 175     


Gly Pro Leu Trp Ala Gly Gly Glu Arg Ser Ser Gly Ala Arg Gln Phe 
            180                 185                 190         


Pro Ala Pro Ala Phe Pro Asp Leu Ser Arg Pro Ala Arg Ala Arg Arg 
        195                 200                 205             


Ala Leu Pro Leu Pro Gly Gly Ser Asp Thr Ala Arg Ala Pro Pro Arg 
    210                 215                 220                 


Thr Arg Thr Glu Thr Arg Thr Gly Thr Gly Ala Ala Leu Glu Ala Pro 
225                 230                 235                 240 


Leu Ala Val Arg Gly Cys Ala Thr Met Ala Asp Lys Glu Ala Gly Gly 
                245                 250                 255     


Ser Asp Gly Pro Arg Glu Thr Ala Pro Thr Ser Ala Tyr Ser Ser Pro 
            260                 265                 270         


Ala Arg Ser Leu Gly Asp Thr Gly Ile Thr Pro Leu Ser Pro Ser His 
        275                 280                 285             


Ile Val Asn Asp Thr Asp Ser Asn Val Ser Glu Gln Gln Ser Phe Leu 
    290                 295                 300                 


Val Val Val Ala Val Asp Phe Gly Thr Thr Ser Ser Gly Tyr Ala Tyr 
305                 310                 315                 320 


Ser Phe Thr Lys Glu Pro Glu Cys Ile His Val Met Arg Arg Trp Glu 
                325                 330                 335     


Gly Gly Asp Pro Gly Val Ser Asn Gln Lys Thr Pro Thr Thr Ile Leu 
            340                 345                 350         


Leu Thr Pro Glu Arg Lys Phe His Ser Phe Gly Tyr Ala Ala Arg Asp 
        355                 360                 365             


Phe Tyr His Asp Leu Asp Pro Asn Glu Ala Lys Gln Trp Leu Tyr Leu 
    370                 375                 380                 


Glu Lys Phe Lys Met Lys Leu His Thr Thr Gly Asp Leu Thr Met Asp 
385                 390                 395                 400 


Thr Asp Leu Thr Ala Ala Asn Gly Lys Lys Val Lys Ala Leu Glu Ile 
                405                 410                 415     


Phe Ala Tyr Ala Leu Gln Tyr Phe Lys Glu Gln Ala Leu Lys Glu Leu 
            420                 425                 430         


Ser Asp Gln Ala Gly Ser Glu Phe Glu Asn Ser Asp Val Arg Trp Val 
        435                 440                 445             


Ile Thr Val Pro Ala Ile Trp Lys Gln Pro Ala Lys Gln Phe Met Arg 
    450                 455                 460                 


Gln Ala Ala Tyr Gln Ala Gly Leu Ala Ser Pro Glu Asn Ser Glu Gln 
465                 470                 475                 480 


Leu Ile Ile Ala Leu Glu Pro Glu Ala Ala Ser Ile Tyr Cys Arg Lys 
                485                 490                 495     


Leu Arg Leu His Gln Met Ile Glu Leu Ser Ser Lys Ala Ala Val Asn 
            500                 505                 510         


Gly Tyr Ser Gly Ser Asp Thr Val Gly Ala Gly Phe Thr Gln Ala Lys 
        515                 520                 525             


Glu His Ile Arg Arg Asn Arg Gln Ser Arg Thr Phe Leu Val Glu Asn 
    530                 535                 540                 


Val Ile Gly Glu Ile Trp Ser Glu Leu Glu Glu Gly Asp Lys Tyr Val 
545                 550                 555                 560 


Val Val Asp Ser Gly Gly Gly Thr Val Asp Leu Thr Val His Gln Ile 
                565                 570                 575     


Arg Leu Pro Glu Gly His Leu Lys Glu Leu Tyr Lys Ala Thr Gly Gly 
            580                 585                 590         


Pro Tyr Gly Ser Leu Gly Val Asp Tyr Glu Phe Glu Lys Leu Leu Tyr 
        595                 600                 605             


Lys Ile Phe Gly Glu Asp Phe Ile Glu Gln Phe Lys Ile Lys Arg Pro 
    610                 615                 620                 


Ala Ala Trp Val Asp Leu Met Ile Ala Phe Glu Ser Arg Lys Arg Ala 
625                 630                 635                 640 


Ala Ala Pro Asp Arg Thr Asn Pro Leu Asn Ile Thr Leu Pro Phe Ser 
                645                 650                 655     


Phe Ile Asp Tyr Tyr Lys Lys Phe Arg Gly His Ser Val Glu His Ala 
            660                 665                 670         


Leu Arg Lys Ser Asn Val Asp Phe Val Lys Trp Ser Ser Gln Gly Met 
        675                 680                 685             


Leu Arg Met Ser Pro Asp Ala Met Asn Ala Leu Phe Lys Pro Thr Ile 
    690                 695                 700                 


Asp Ser Ile Ile Glu His Leu Arg Asp Leu Phe Gln Lys Pro Glu Val 
705                 710                 715                 720 


Ser Thr Val Lys Phe Leu Phe Leu Val Gly Gly Phe Ala Glu Ala Pro 
                725                 730                 735     


Leu Leu Gln Gln Ala Val Gln Ala Ala Phe Gly Asp Gln Cys Arg Ile 
            740                 745                 750         


Ile Ile Pro Gln Asp Val Gly Leu Thr Ile Leu Lys Gly Ala Val Leu 
        755                 760                 765             


Phe Gly Leu Asp Pro Ala Val Ile Lys Val Arg Arg Ser Pro Leu Thr 
    770                 775                 780                 


Tyr Gly Val Gly Val Leu Asn Arg Tyr Val Glu Gly Lys His Pro Pro 
785                 790                 795                 800 


Glu Lys Leu Leu Val Lys Asp Gly Thr Arg Trp Cys Thr Asp Val Phe 
                805                 810                 815     


Asp Lys Phe Ile Ser Ala Asp Gln Ser Val Ala Leu Gly Glu Leu Val 
            820                 825                 830         


Lys Arg Ser Tyr Thr Pro Ala Lys Pro Ser Gln Leu Val Ile Val Ile 
        835                 840                 845             


Asn Ile Tyr Ser Ser Glu His Asp Asn Val Ser Phe Ile Thr Asp Pro 
    850                 855                 860                 


Gly Val Lys Lys Cys Gly Thr Leu Arg Leu Asp Leu Thr Gly Thr Ser 
865                 870                 875                 880 


Gly Thr Ala Val Pro Ala Arg Arg Glu Ile Gln Thr Leu Met Gln Phe 
                885                 890                 895     


Gly Asp Thr Glu Ile Lys Ala Thr Ala Ile Asp Ile Ala Thr Ser Lys 
            900                 905                 910         


Ser Val Lys Val Gly Ile Asp Phe Leu Asn Tyr 
        915                 920             


<210>  2606
<211>  3917
<212>  DNA
<213>  Homosapiens

<400>  2606
atggagttgt ccagagagct cgcccttgct gcgagccact cccagccact gcctccacac     60

ctactacagc cgattggcac ctgtagccac tgtgatgctg ctgcatccac tttggaggtg    120

tcggtgctac ctctcctgct ggtacagaca ccgccagtgc tggtgccacc accaccacgt    180

gagtgtcacc aacactgcca gcgccaggct caccgccact gccatgtcac tggagccacc    240

aactcacaac accgcagggc cagcgcagtg gtggggaaga gtgaagctct gggtgttgtt    300

tgctcaagtc ccactcagtt tgaaggcaga tgtgggacaa actgggtgac aagacgtcat    360

gaagtgctcc gaactgcccc tcttctccaa ataaagcttc attctggact atttggggat    420

gtccaaggga caggacttag tccctcagga ttcgtctgtt cttacaactt tgaactctat    480

gtggatgttg tctatcagga tcttcagtcc tcccttttct ctgggatacc aatgctactc    540

aagctctaca catctaacac ccaatgcatc atatcgcctc catcaaaacc agatgacgca    600

ctgatcctat ttccgttaac tatcacagaa ttctacaagg gccccaggct ccgtggtgga    660

tgtgaaggta acacagactc agattctacc gtcaggggat ttccatctag caaggagaga    720

aggcaggttc atgatggtcc attacacaca gacagtgaga cgttccgtaa gagagcagag    780

agaacacgga ggaagtttgg aagagtgggc ctgcctggca cgggcggcct tagcaacccg    840

gaggagctca ctaacagcag agagcaaggg ggcgcgtggg gagggcgggg tggcccaaga    900

cgctgggcca ctgggacccg agcgcgcgac cccagccgga attcggagct aaggctgccg    960

cgctccggca aaacgcgctt gatgaggaag aacctaggcc tggaagccac gcgagatctg   1020

ggggtcggga tcacgttgcg ttgcctagcg acagcaggga cgctcgtggg accccaggct   1080

aaaccccgct gtagccttaa atctcctacc atggaggaag aaggcggcgg ccgcagctgt   1140

gggaccacta gggagctgca gaagctgaag cagcaggcga tggagtacta ccgggagaac   1200

gacgttccgc gcaggctgga agagctgctc aactccacct tctacctcca gcctgccgac   1260

gtctacgggc acctgaaagc aaactgcttt tctaaacttg caaagcctcc caccatatgc   1320

aaaatagtgg ggaaagacgt actagatgga ctggggcttc caaccctgca agtggacata   1380

ttctgcacca ttcaaaactt tcccaagaac gtatgttctg tggtgatctc gactcatttt   1440

gaagtccatg agaatgctct gcccgagctg gccaaggcgg aggaggcaga gagggccagc   1500

gcggtgagca ccgccgtgca gtgggtcaac agcaccatca cgcacgagct ccaggggatg   1560

gcaccctctg accaggcaga ggtggatcac ctactcagga tattcttcgc aagtaaagta   1620

caagaagata aggggagaaa agaattggaa aagagcctgg aatactcaac agtgcctaca   1680

cctctacctc cagtaccacc accaccaccc cctccacctc ctaccaaaaa aaaggggcaa   1740

aagccaggga ggaaggatac tattacagag aaacctattg cgcctgcaga gcctgttgag   1800

cctgtactca gtggcagtat ggccataggg gccgtgtcac tagctgttgc caaagcctgt   1860

gccatgctgc ttaataaacc tctgtactta aatatcgctc tactgaagca caatcaggaa   1920

cagccaacaa cgctatctat gcctttgctg atggtatcgc tggtcagctg tgggaagtca   1980

tcatctggga agctaaattt aatgaaagaa gtgatttgta taccccatcc tgaattaaca   2040

accaaacaag gtgtcgagat gcttatggaa atgcagaaac atatcaacaa aataattgaa   2100

atgccctctc ctccaaaagc agagacaaaa aaagggcacg atggaagcaa aagaggtcaa   2160

cagcagatca ctggcaagat gtctcatctt ggctgtttaa ccattaactg tgactccata   2220

gaacagccac tgcttctaat acaggaaatc tgtgccaacc tggggctaga actgggaaca   2280

aatctgcatc tagctatcaa ctgtgctgga catgagctga tggactacaa taaaggaaag   2340

tatgaagtga tcatgggcac atacaaaaat gcagcggaga tggttgacct gtatgtggat   2400

ctgatcaaca agtacccttc aattattgcc ttaattgatc ctttcaggaa ggaggactct   2460

gaacagtggg acagcatcta tcacgcactt ggttccaggt gttacataat tgcaggaact   2520

gcttccaaaa gcatttctaa acttctagag caaggaaaca tcagcatccc caaatccaat   2580

gggctgatca taaaacacac aaaccaaact acaatgtctg acttggtgga aataaccaat   2640

ctgattgaca gtaagaagca catcactgtc tttggaagta cagaaggaga atcatctgat   2700

gacagccttg tcgatttggc tgttgggctt ggtgtccggt tcatcaagtt ggggggtctt   2760

tcccgtggtg aacgagtgac taaatacaac cgccttctca ctatagagga agaacttgtc   2820

cagaatggaa cactgggttt caaagaagaa cacacttttt tttactttaa tgaggaagct   2880

gaaaaggctg cggaggcact tgaggctgct gcggctaggg agccgctggt gcccaccttc   2940

cccacacaag gtgtagagga atcagccgaa acaggagcat cctctggata gggctgtaca   3000

caccccaggt tccagccaca ccatcagtat tagtagaccg ggaggtctga agtacggcgc   3060

cgtgtctcca catggagttt cctcttcaac ttcaccaact cttgtggttt ttattcttct   3120

aattccactg tttggtaaat tacatatatg atgtttttgc ctgaaattct gtgaacttcg   3180

ttttgcagcc accacacttc catgtggatt ttgtttgtct attagctctc ctgtccattt   3240

ttcagggaca cgctccagta aaagaggcca atatttttgt tgccaactcc acactcagtc   3300

aaacacccca tcctttacca atcagaatat ctctgagaac aaaaacctaa tgaccctaga   3360

agctctctgt gctgggaaca gatgtccatc ttctgtgttt attctacatg tctgtgctga   3420

aaagcactga cacatttttg taaccaacct cacgtagaag tgtgagagca tcaccatttt   3480

ttgtaagagc caatttcatc tcactttcct acccttgatt ccttttttcc taattccctc   3540

tcctttttaa attttagttt ttcttgtatt atttttatct ttgcgagtct tcttagatcc   3600

tttttggagt aagaatgagt ataaatgaat aagcacatca gtaaatgaat taatattctc   3660

aaggttatta aatgcccagt tattcatacc acagcattta aaaagcaatc cgcaagtgat   3720

aaaaaaaaaa aaaaaaaatg atgtgacata tccattgcct gaattgctct tttgtaagcc   3780

agtgttggga ttatagcaga ggagtagcag aaataaatat attcagacac aaacatatag   3840

atataataat atccaaccac tttatatgat ttagggtctc gttaaaatgg ttaccatttg   3900

cttctcctaa aaattat                                                  3917


<210>  2607
<211>  996
<212>  PRT
<213>  Homosapiens

<400>  2607

Met Glu Leu Ser Arg Glu Leu Ala Leu Ala Ala Ser His Ser Gln Pro 
1               5                   10                  15      


Leu Pro Pro His Leu Leu Gln Pro Ile Gly Thr Cys Ser His Cys Asp 
            20                  25                  30          


Ala Ala Ala Ser Thr Leu Glu Val Ser Val Leu Pro Leu Leu Leu Val 
        35                  40                  45              


Gln Thr Pro Pro Val Leu Val Pro Pro Pro Pro Arg Glu Cys His Gln 
    50                  55                  60                  


His Cys Gln Arg Gln Ala His Arg His Cys His Val Thr Gly Ala Thr 
65                  70                  75                  80  


Asn Ser Gln His Arg Arg Ala Ser Ala Val Val Gly Lys Ser Glu Ala 
                85                  90                  95      


Leu Gly Val Val Cys Ser Ser Pro Thr Gln Phe Glu Gly Arg Cys Gly 
            100                 105                 110         


Thr Asn Trp Val Thr Arg Arg His Glu Val Leu Arg Thr Ala Pro Leu 
        115                 120                 125             


Leu Gln Ile Lys Leu His Ser Gly Leu Phe Gly Asp Val Gln Gly Thr 
    130                 135                 140                 


Gly Leu Ser Pro Ser Gly Phe Val Cys Ser Tyr Asn Phe Glu Leu Tyr 
145                 150                 155                 160 


Val Asp Val Val Tyr Gln Asp Leu Gln Ser Ser Leu Phe Ser Gly Ile 
                165                 170                 175     


Pro Met Leu Leu Lys Leu Tyr Thr Ser Asn Thr Gln Cys Ile Ile Ser 
            180                 185                 190         


Pro Pro Ser Lys Pro Asp Asp Ala Leu Ile Leu Phe Pro Leu Thr Ile 
        195                 200                 205             


Thr Glu Phe Tyr Lys Gly Pro Arg Leu Arg Gly Gly Cys Glu Gly Asn 
    210                 215                 220                 


Thr Asp Ser Asp Ser Thr Val Arg Gly Phe Pro Ser Ser Lys Glu Arg 
225                 230                 235                 240 


Arg Gln Val His Asp Gly Pro Leu His Thr Asp Ser Glu Thr Phe Arg 
                245                 250                 255     


Lys Arg Ala Glu Arg Thr Arg Arg Lys Phe Gly Arg Val Gly Leu Pro 
            260                 265                 270         


Gly Thr Gly Gly Leu Ser Asn Pro Glu Glu Leu Thr Asn Ser Arg Glu 
        275                 280                 285             


Gln Gly Gly Ala Trp Gly Gly Arg Gly Gly Pro Arg Arg Trp Ala Thr 
    290                 295                 300                 


Gly Thr Arg Ala Arg Asp Pro Ser Arg Asn Ser Glu Leu Arg Leu Pro 
305                 310                 315                 320 


Arg Ser Gly Lys Thr Arg Leu Met Arg Lys Asn Leu Gly Leu Glu Ala 
                325                 330                 335     


Thr Arg Asp Leu Gly Val Gly Ile Thr Leu Arg Cys Leu Ala Thr Ala 
            340                 345                 350         


Gly Thr Leu Val Gly Pro Gln Ala Lys Pro Arg Cys Ser Leu Lys Ser 
        355                 360                 365             


Pro Thr Met Glu Glu Glu Gly Gly Gly Arg Ser Cys Gly Thr Thr Arg 
    370                 375                 380                 


Glu Leu Gln Lys Leu Lys Gln Gln Ala Met Glu Tyr Tyr Arg Glu Asn 
385                 390                 395                 400 


Asp Val Pro Arg Arg Leu Glu Glu Leu Leu Asn Ser Thr Phe Tyr Leu 
                405                 410                 415     


Gln Pro Ala Asp Val Tyr Gly His Leu Lys Ala Asn Cys Phe Ser Lys 
            420                 425                 430         


Leu Ala Lys Pro Pro Thr Ile Cys Lys Ile Val Gly Lys Asp Val Leu 
        435                 440                 445             


Asp Gly Leu Gly Leu Pro Thr Leu Gln Val Asp Ile Phe Cys Thr Ile 
    450                 455                 460                 


Gln Asn Phe Pro Lys Asn Val Cys Ser Val Val Ile Ser Thr His Phe 
465                 470                 475                 480 


Glu Val His Glu Asn Ala Leu Pro Glu Leu Ala Lys Ala Glu Glu Ala 
                485                 490                 495     


Glu Arg Ala Ser Ala Val Ser Thr Ala Val Gln Trp Val Asn Ser Thr 
            500                 505                 510         


Ile Thr His Glu Leu Gln Gly Met Ala Pro Ser Asp Gln Ala Glu Val 
        515                 520                 525             


Asp His Leu Leu Arg Ile Phe Phe Ala Ser Lys Val Gln Glu Asp Lys 
    530                 535                 540                 


Gly Arg Lys Glu Leu Glu Lys Ser Leu Glu Tyr Ser Thr Val Pro Thr 
545                 550                 555                 560 


Pro Leu Pro Pro Val Pro Pro Pro Pro Pro Pro Pro Pro Pro Thr Lys 
                565                 570                 575     


Lys Lys Gly Gln Lys Pro Gly Arg Lys Asp Thr Ile Thr Glu Lys Pro 
            580                 585                 590         


Ile Ala Pro Ala Glu Pro Val Glu Pro Val Leu Ser Gly Ser Met Ala 
        595                 600                 605             


Ile Gly Ala Val Ser Leu Ala Val Ala Lys Ala Cys Ala Met Leu Leu 
    610                 615                 620                 


Asn Lys Pro Leu Tyr Leu Asn Ile Ala Leu Leu Lys His Asn Gln Glu 
625                 630                 635                 640 


Gln Pro Thr Thr Leu Ser Met Pro Leu Leu Met Val Ser Leu Val Ser 
                645                 650                 655     


Cys Gly Lys Ser Ser Ser Gly Lys Leu Asn Leu Met Lys Glu Val Ile 
            660                 665                 670         


Cys Ile Pro His Pro Glu Leu Thr Thr Lys Gln Gly Val Glu Met Leu 
        675                 680                 685             


Met Glu Met Gln Lys His Ile Asn Lys Ile Ile Glu Met Pro Ser Pro 
    690                 695                 700                 


Pro Lys Ala Glu Thr Lys Lys Gly His Asp Gly Ser Lys Arg Gly Gln 
705                 710                 715                 720 


Gln Gln Ile Thr Gly Lys Met Ser His Leu Gly Cys Leu Thr Ile Asn 
                725                 730                 735     


Cys Asp Ser Ile Glu Gln Pro Leu Leu Leu Ile Gln Glu Ile Cys Ala 
            740                 745                 750         


Asn Leu Gly Leu Glu Leu Gly Thr Asn Leu His Leu Ala Ile Asn Cys 
        755                 760                 765             


Ala Gly His Glu Leu Met Asp Tyr Asn Lys Gly Lys Tyr Glu Val Ile 
    770                 775                 780                 


Met Gly Thr Tyr Lys Asn Ala Ala Glu Met Val Asp Leu Tyr Val Asp 
785                 790                 795                 800 


Leu Ile Asn Lys Tyr Pro Ser Ile Ile Ala Leu Ile Asp Pro Phe Arg 
                805                 810                 815     


Lys Glu Asp Ser Glu Gln Trp Asp Ser Ile Tyr His Ala Leu Gly Ser 
            820                 825                 830         


Arg Cys Tyr Ile Ile Ala Gly Thr Ala Ser Lys Ser Ile Ser Lys Leu 
        835                 840                 845             


Leu Glu Gln Gly Asn Ile Ser Ile Pro Lys Ser Asn Gly Leu Ile Ile 
    850                 855                 860                 


Lys His Thr Asn Gln Thr Thr Met Ser Asp Leu Val Glu Ile Thr Asn 
865                 870                 875                 880 


Leu Ile Asp Ser Lys Lys His Ile Thr Val Phe Gly Ser Thr Glu Gly 
                885                 890                 895     


Glu Ser Ser Asp Asp Ser Leu Val Asp Leu Ala Val Gly Leu Gly Val 
            900                 905                 910         


Arg Phe Ile Lys Leu Gly Gly Leu Ser Arg Gly Glu Arg Val Thr Lys 
        915                 920                 925             


Tyr Asn Arg Leu Leu Thr Ile Glu Glu Glu Leu Val Gln Asn Gly Thr 
    930                 935                 940                 


Leu Gly Phe Lys Glu Glu His Thr Phe Phe Tyr Phe Asn Glu Glu Ala 
945                 950                 955                 960 


Glu Lys Ala Ala Glu Ala Leu Glu Ala Ala Ala Ala Arg Glu Pro Leu 
                965                 970                 975     


Val Pro Thr Phe Pro Thr Gln Gly Val Glu Glu Ser Ala Glu Thr Gly 
            980                 985                 990         


Ala Ser Ser Gly 
        995     


<210>  2608
<211>  3417
<212>  DNA
<213>  Homosapiens

<400>  2608
cgaggctggc atagcggctg ccgacccgcc ttcgttcctc caccccctgc acgggactgc     60

tgggcccgcc ccgccccgcc tgcaggtgaa gcggccgcag ccgccgagta ggtgcgtggg    120

gatgatctca ctcgcgcgct ccgcgccagg aggaggagga gcgggagcgg atccaacttc    180

cgggtagtgg agccgcaagc caccggcatc ttgctttttc ttccccctcc tcctgtgtgc    240

cccgcgccgc tccctctttc ccttttattc ccggccccac ccgccaaaat gaacagctcg    300

gacgaagaga agcagctgca gctcattacc agtctgaagg agcaagcaat aggcgaatat    360

gaagacctta gagcagagaa ccagaaaaca aaggagaagt gtgacaaaat taggcaagaa    420

cgagatgaag ccgttaaaaa actggaagaa tttcagaaaa tttctcacat ggtcatagag    480

gaagttaatt tcatgcagaa ccatcttgaa atagagaaga cttgtcgaga aagtgctgaa    540

gctttggcaa caaagctaaa taaagaaaat aaaacgttga aaagaatcag catgttgtac    600

atggccaagc tgggaccaga tgtaataact gaagagataa acattgatga tgaagattcg    660

actacagaca cagacggtgc cgccgagact tgtgtctcag tacagtgtca gaagcaaatt    720

aaagaacttc gagatcaaat tgtatctgtt caggaggaaa agaagatttt agccattgag    780

ctggaaaatc tcaagagcaa actcgtagaa gtaattgaag aagtaaataa agttaaacaa    840

gaaaagactg ttttaaattc agaagttctt gaacagagaa aagtcttaga aaaatgcaat    900

agagtgtcca tgttagctgt agaagagtat gaggagatgc aagtaaacct ggagctggag    960

aaggaccttc gaaagaaagc agagtcattt gcacaagaga tgttcattga gcaaaacaag   1020

ctaaagagac aaagccacct tctgctgcag agctccatcc ctgatcagca gcttttgaaa   1080

gctttagacg aaaatgcaaa actcacccag caacttgaag aagagagaat tcagcatcaa   1140

caaaaggtca aagaattaga agagcaacta gaaaatgaaa cactccacaa agaaatacac   1200

aacctcaaac agcaactgga gcttctagag gaagataaaa aggaattgga attgaaatat   1260

cagaattctg aagagaaagc cagaaattta aagcactctg ttgatgaact ccagaaacga   1320

gtgaaccagt ctgagaattc agtacctcca ccacctcctc ctccaccacc acttccccct   1380

ccacctccca atcctatccg atccctcatg tccatgatcc ggaaacgatc ccaccccagt   1440

ggcagtggtg ctaagaaaga aaaggcaact caaccagaaa caactgaaga agtcacagat   1500

ctaaagaggc aagcagttga agagatgatg gatagaatta aaaagggagt tcatcttaga   1560

cccgttaatc agacagccag accgaagaca aagccagaat cttcgaaagg ctgcgaaagt   1620

gcagtggatg aactaaaagg aatactggcc tcccagtagc attggatgca ggaaaaaata   1680

cattgacggt gaaaaacaag ccgaaccagt tgtagtttta gatcctgttt ctacacatga   1740

accccaaacc aaagaccagg ttgctgaaaa agatccaact caacacaagg aggatgaagg   1800

cgaaattcaa ccagaaaaca aagaagacag cattgaaaac gtgagagaga cagacagctc   1860

caactgctga tccataaacc agaagcctga tacgtttgga agtccttttc aataagcaca   1920

tgattagtgt tgttatattg gcaagggctg tagacattct gctctggtca ctgtattcag   1980

aatacaggtt cttttctggt gtcacttttg taagtagcaa ctataaacat aagtaagctg   2040

tttagcaaaa cacacattcc tagtaggttt tggttttttg atctttataa agatgaggtt   2100

tttttcctag ttactgtatt aagtatgact tcttttagaa ggttacaaaa aaattcagat   2160

gttgatacct ttttaggaaa tgtgcatacc actcatcaaa tggaatgctg aaagtttgag   2220

gtgcttgtat ataatcggat aaacaaaact gatcaaccca atgtgatttt aaaagccccc   2280

aaagaagctt ctgttttggg tctgatcctc ttgatggaga aactgcagca gcatggaaat   2340

tgttgggtac tgtggcatac aagttatttt ctacagtaga ctgagataaa ctgaaaactc   2400

aggagctggc atcaaactcg tagtcccata gtcagtgtta attacacaca ttgttaacta   2460

ttggatgaaa aatacatgct attgattgtg tccaaagcct cccgaggacc tccgtgggga   2520

tgctctggta gcctgaatac agaactgagg tgaaagtcca aaccttgaat tttacagtag   2580

taagttggta aaccatgtgc tctgtgctat gagttaatta tgttttccca aatactaatg   2640

tggcacaagt accatatttt atcagagttc ttatgtacag tatggtgaag ataagtgaca   2700

agcacacatt tttcttgctt cactgctgtt ctatattaca caggtttgtt gttgtttttt   2760

ttaaaaaaga aattaagcag tagttagtct ctaaaaatac aatgtttcag gctaccacag   2820

tgaataaata gaaatgtaat cagggattaa aaaaaaaact tatgcagctt ttcaaagttg   2880

attgtttcaa aattggtgtt tatttaaaat aagtggtaat gtacttgaat gcacttttta   2940

tgacaatgat tcagtaatgg taattttact attaaagaaa gtgaaaggtt tagttttgtt   3000

agcatggctc agcatgtagc tgtcaggtgt ttttcaccta agggcaaaag aaaatgatag   3060

taataattgc agtagttgta ttgtattgta tttttgcacg tgtggtaagc ataggcttga   3120

agaggtgggt aggcaggtac atgtacttcc taaattttga gataattatc tttctgtaag   3180

ttcgttatgc ttgactgttt ccatgttctc ccaataatga ttttatagtt acttatcact   3240

ttactcatgg agaattaaaa cgtaatgttt ttcaactgta tctttcttta actggataat   3300

actgctatat gatatgctta ctacagactg cattaattca cgaaacgaat tctgttatgc   3360

tgtaatttga actctcctca ccacaactta ttaaaaaggc accaatagtt tcccatt      3417


<210>  2609
<211>  456
<212>  PRT
<213>  Homosapiens

<400>  2609

Met Asn Ser Ser Asp Glu Glu Lys Gln Leu Gln Leu Ile Thr Ser Leu 
1               5                   10                  15      


Lys Glu Gln Ala Ile Gly Glu Tyr Glu Asp Leu Arg Ala Glu Asn Gln 
            20                  25                  30          


Lys Thr Lys Glu Lys Cys Asp Lys Ile Arg Gln Glu Arg Asp Glu Ala 
        35                  40                  45              


Val Lys Lys Leu Glu Glu Phe Gln Lys Ile Ser His Met Val Ile Glu 
    50                  55                  60                  


Glu Val Asn Phe Met Gln Asn His Leu Glu Ile Glu Lys Thr Cys Arg 
65                  70                  75                  80  


Glu Ser Ala Glu Ala Leu Ala Thr Lys Leu Asn Lys Glu Asn Lys Thr 
                85                  90                  95      


Leu Lys Arg Ile Ser Met Leu Tyr Met Ala Lys Leu Gly Pro Asp Val 
            100                 105                 110         


Ile Thr Glu Glu Ile Asn Ile Asp Asp Glu Asp Ser Thr Thr Asp Thr 
        115                 120                 125             


Asp Gly Ala Ala Glu Thr Cys Val Ser Val Gln Cys Gln Lys Gln Ile 
    130                 135                 140                 


Lys Glu Leu Arg Asp Gln Ile Val Ser Val Gln Glu Glu Lys Lys Ile 
145                 150                 155                 160 


Leu Ala Ile Glu Leu Glu Asn Leu Lys Ser Lys Leu Val Glu Val Ile 
                165                 170                 175     


Glu Glu Val Asn Lys Val Lys Gln Glu Lys Thr Val Leu Asn Ser Glu 
            180                 185                 190         


Val Leu Glu Gln Arg Lys Val Leu Glu Lys Cys Asn Arg Val Ser Met 
        195                 200                 205             


Leu Ala Val Glu Glu Tyr Glu Glu Met Gln Val Asn Leu Glu Leu Glu 
    210                 215                 220                 


Lys Asp Leu Arg Lys Lys Ala Glu Ser Phe Ala Gln Glu Met Phe Ile 
225                 230                 235                 240 


Glu Gln Asn Lys Leu Lys Arg Gln Ser His Leu Leu Leu Gln Ser Ser 
                245                 250                 255     


Ile Pro Asp Gln Gln Leu Leu Lys Ala Leu Asp Glu Asn Ala Lys Leu 
            260                 265                 270         


Thr Gln Gln Leu Glu Glu Glu Arg Ile Gln His Gln Gln Lys Val Lys 
        275                 280                 285             


Glu Leu Glu Glu Gln Leu Glu Asn Glu Thr Leu His Lys Glu Ile His 
    290                 295                 300                 


Asn Leu Lys Gln Gln Leu Glu Leu Leu Glu Glu Asp Lys Lys Glu Leu 
305                 310                 315                 320 


Glu Leu Lys Tyr Gln Asn Ser Glu Glu Lys Ala Arg Asn Leu Lys His 
                325                 330                 335     


Ser Val Asp Glu Leu Gln Lys Arg Val Asn Gln Ser Glu Asn Ser Val 
            340                 345                 350         


Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Asn 
        355                 360                 365             


Pro Ile Arg Ser Leu Met Ser Met Ile Arg Lys Arg Ser His Pro Ser 
    370                 375                 380                 


Gly Ser Gly Ala Lys Lys Glu Lys Ala Thr Gln Pro Glu Thr Thr Glu 
385                 390                 395                 400 


Glu Val Thr Asp Leu Lys Arg Gln Ala Val Glu Glu Met Met Asp Arg 
                405                 410                 415     


Ile Lys Lys Gly Val His Leu Arg Pro Val Asn Gln Thr Ala Arg Pro 
            420                 425                 430         


Lys Thr Lys Pro Glu Ser Ser Lys Gly Cys Glu Ser Ala Val Asp Glu 
        435                 440                 445             


Leu Lys Gly Ile Leu Ala Ser Gln 
    450                 455     


<210>  2610
<211>  5504
<212>  DNA
<213>  Homosapiens

<400>  2610
gactgctggc cgtggatcca tttcacaggc ctgccttctc tcactaacgc tcttcctagt     60

ccccgggcca actcggacag tttgctcatt tattgcaacg gtcaaggctg gcttgtgcca    120

gaacggcgcg cgcgcgcgca cgcacgcaca cacacggggg gaaacttttt taaaaatgaa    180

aggctagaag agctcagcgg cggcgcgggc gctgcgcgag ggctccggag ctgactcgcc    240

gaggcaggaa atccctccgg tcgcgacgcc cggccccggc tcggcgcccg cgtgggatgg    300

tgcagcgctc gccgccgggc ccgagagctg ctgcactgaa ggccggcgac gatggcagcg    360

cgcccgctgc ccgtgtcccc cgcccgcgcc ctcctgctcg ccctggccgg tgctctgctc    420

gcgccctgcg aggcccgagg ggtgagctta tggaaccaag gaagagctga tgaagttgtc    480

agtgcctctg ttgggagtgg ggacctctgg atcccagtga agagcttcga ctccaagaat    540

catccagaag tgctgaatat tcgactacaa cgggaaagca aagaactgat cataaatctg    600

gaaagaaatg aaggtctcat tgccagcagt ttcacggaaa cccactatct gcaagacggt    660

actgatgtct ccctcgctcg aaattacacg gtaattctgg gtcactgtta ctaccatgga    720

catgtacggg gatattctga ttcagcagtc agtctcagca cgtgttctgg tctcagggga    780

cttattgtgt ttgaaaatga aagctatgtc ttagaaccaa tgaaaagtgc aaccaacaga    840

tacaaactct tcccagcgaa gaagctgaaa agcgtccggg gatcatgtgg atcacatcac    900

aacacaccaa acctcgctgc aaagaatgtg tttccaccac cctctcagac atgggcaaga    960

aggcataaaa gagagaccct caaggcaact aagtatgtgg agctggtgat cgtggcagac   1020

aaccgagagt ttcagaggca aggaaaagat ctggaaaaag ttaagcagcg attaatagag   1080

attgctaatc acgttgacaa gttttacaga ccactgaaca ttcggatcgt gttggtaggc   1140

gtggaagtgt ggaatgacat ggacaaatgc tctgtaagtc aggacccatt caccagcctc   1200

catgaatttc tggactggag gaagatgaag cttctacctc gcaaatccca tgacaatgcg   1260

cagcttgtca gtggggttta tttccaaggg accaccatcg gcatggcccc aatcatgagc   1320

atgtgcacgg cagaccagtc tgggggaatt gtcatggacc attcagacaa tccccttggt   1380

gcagccgtga ccctggcaca tgagctgggc cacaatttcg ggatgaatca tgacacactg   1440

gacaggggct gtagctgtca aatggcggtt gagaaaggag gctgcatcat gaacgcttcc   1500

accgggtacc catttcccat ggtgttcagc agttgcagca ggaaggactt ggagaccagc   1560

ctggagaaag gaatgggggt gtgcctgttt aacctgccgg aagtcaggga gtctttcggg   1620

ggccagaagt gtgggaacag atttgtggaa gaaggagagg agtgtgactg tggggagcca   1680

gaggaatgta tgaatcgctg ctgcaatgcc accacctgta ccctgaagcc ggacgctgtg   1740

tgcgcacatg ggctgtgctg tgaagactgc cagctgaagc ctgcaggaac agcgtgcagg   1800

gactccagca actcctgtga cctcccagag ttctgcacag gggccagccc tcactgccca   1860

gccaacgtgt acctgcacga tgggcactca tgtcaggatg tggacggcta ctgctacaat   1920

ggcatctgcc agactcacga gcagcagtgt gtcacgctct ggggaccagg tgctaaacct   1980

gcccctggga tctgctttga gagagtcaat tctgcaggtg atccttatgg caactgtggc   2040

aaagtctcga agagttcctt tgccaaatgc gagatgagag atgctaaatg tggaaaaatc   2100

cagtgtcaag gaggtgccag ccggccagtc attggtacca atgccgtttc catagaaaca   2160

aacatccccc tgcagcaagg aggccggatt ctgtgccggg ggacccacgt gtacttgggc   2220

gatgacatgc cggacccagg gcttgtgctt gcaggcacaa agtgtgcaga tggaaaaatc   2280

tgcctgaatc gtcaatgtca aaatattagt gtctttgggg ttcacgagtg tgcaatgcag   2340

tgccacggca gaggggtgtg caacaacagg aagaactgcc actgcgaggc ccactgggca   2400

cctcccttct gtgacaagtt tggctttgga ggaagcacag acagcggccc catccggcaa   2460

gcagataacc aaggtttaac cataggaatt ctggtgacca tcctgtgtct tcttgctgcc   2520

ggatttgtgg tttatctcaa aaggaagacc ttgatacgac tgctgtttac aaataagaag   2580

accaccattg aaaaactaag gtgtgtgcgc ccttcccggc caccccgtgg cttccaaccc   2640

tgtcaggctc acctcggcca ccttggaaaa ggcctgatga ggaagccgcc agattcctac   2700

ccaccgaagg acaatcccag gagattgctg cagtgtcaga atgttgacat cagcagaccc   2760

ctcaacggcc tgaatgtccc tcagccccag tcaactcagc gagtgcttcc tcccctccac   2820

cgggccccac gtgcacctag cgtccctgcc agacccctgc cagccaagcc tgcacttagg   2880

caggcccagg ggacctgtaa gccaaacccc cctcagaagc ctctgcctgc agatcctctg   2940

gccagaacaa ctcggctcac tcatgccttg gccaggaccc caggacaatg ggagactggg   3000

ctccgcctgg cacccctcag acctgctcca caatatccac accaagtgcc cagatccacc   3060

cacaccgcct atattaagtg agaagccgac accttttttc aacagtgaag acagaagttt   3120

gcactatctt tcagctccag ttggagtttt ttgtaccaac ttttaggatt ttttttaatg   3180

tttaaaacat cattactata agaactttga gctactgccg tcagtgctgt gctgtgctat   3240

ggtgctctgt ctacttgctc aggtacttgt aaattattaa tttatgcaga atgttgatta   3300

cagtgcagtg cgctgtagta ggcattttta ccatcactga gttttccatg gcaggaaggc   3360

ttgttgtgct tttagtattt tagtgaactt gaaatatcct gcttgatggg attctggaca   3420

ggatgtgttt gctttctgat caaggcctta ttggaaagca gtcccccaac tacccccagc   3480

tgtgcttatg gtaccagatg cagctcaaga gatcccaagt agaatctcag ttgattttct   3540

ggattcccca tctcaggcca gagccaaggg gcttcaggtc caggctgtgt ttggctttca   3600

gggaggccct gtgccccttg acaactggca ggcaggctcc cagggacacc tgggagaaat   3660

ctggcttctg gccaggaagc tttggtgaga acctgggttg cagacaggaa tcttaaggtg   3720

tagccacacc aggatagaga ctggaacact agacaagcca gaacttgacc ctgagctgac   3780

cagccgtgag catgtttgga aggggtctgt agtgtcactc aaggcggtgc ttgatagaaa   3840

tgccaagcac ttctttttct cgctgtcctt tctagagcac tgccaccagt aggttattta   3900

gcttgggaaa ggtggtgttt ctgtaagaaa cctactgccc aggcactgca aaccgccacc   3960

tccctatact gcttggagct gagcaaatca ccacaaactg taatacaatg atcctgtatt   4020

cagacagatg aggctttcca tgggaccaca actattttca gatgtgaacc attaaccaga   4080

tctagtcaat caagtctgtt tactgcaagg ttcaacttat taacaattag gcagactctt   4140

tatgcttgca aaaactacaa ccaatggaat gtgatgttca tgggtatagt tcatgtctgc   4200

tatcattatt cgtagatatt ggacaaagaa ccttctctat ggggcatcct ctttttccaa   4260

cttggctgca ggaatcttta aaagatgctt ttaacagagt ctgaacctat ttcttaaaca   4320

cttgcaacct acctgttgag catcacagaa tgtgataagg aaatcaactt gcttatcaac   4380

ttcctaaata ttatgagatg ctggcttggg cagcatcccc ttgaactctt cactcttcaa   4440

atgcctgact agggagccat gtttcacaag gtctttaaag tgactaatgg catgagaaat   4500

acaaaaatac tcagataagg taaaatgcca tgatgcctct gtcttctgga ctggttttca   4560

cattagaaga caattgacaa cagttacata attcactctg agtgttttat gagaaagcct   4620

tcttttgggg gtcaacagtt ttcctatgct ttgaaacaga aaaatatgta ccaagaatct   4680

tggtttgcct tccagaaaac aaaactgcat ttcactttcc cggtgttccc cactgtatct   4740

aggcaacata gtattcatga ctatggataa actaaacacg tgacacaaac acacacaaaa   4800

gggaacccag ctctaataca ttccaactcg tatagcatgc atctgtttat tctatagtta   4860

ttaagttctt taaaatgtaa agccatgctg gaaaataata ctgctgagat acatacagaa   4920

ttactgtaac tgattacact tggtaattgt actaaagcca aacatatata tactattaaa   4980

aaggtttaca gaattttatg gtgcattacg tgggcattgt ctttttagat gcccaaatcc   5040

ttagatctgg catgttagcc cttcctccaa ttataagagg atatgaactg agtttttctt   5100

ttgttgtttg ttcttagctg taattcctat gcttctattt cagagagcca ggagagtttg   5160

atattaaagg aggttaaaac tgtgatctta tgccatgtca tcaatggcca cttaggggcc   5220

atggctgatg acacattctt atctctacag tactaatgtg ttattataga gccatgcatt   5280

ttatttctga ataagaacat atttaaacta atattccctt acaatatgga cagtattaat   5340

ccttccaaga tgcagtattt atcaagtgaa gcatatttag cagcaaattc cattttaaca   5400

taacttagga accaataacc agggtgtttt gtggttgggg gaggcacggg gtggagtatt   5460

cttttttata tcctcaaaac aaaaaaaatc aatacttata tttc                    5504


<210>  2611
<211>  909
<212>  PRT
<213>  Homosapiens

<400>  2611

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Asp Asn Gln Gly Leu Thr Ile Gly Ile Leu Val Thr Ile Leu Cys Leu 
705                 710                 715                 720 


Leu Ala Ala Gly Phe Val Val Tyr Leu Lys Arg Lys Thr Leu Ile Arg 
                725                 730                 735     


Leu Leu Phe Thr Asn Lys Lys Thr Thr Ile Glu Lys Leu Arg Cys Val 
            740                 745                 750         


Arg Pro Ser Arg Pro Pro Arg Gly Phe Gln Pro Cys Gln Ala His Leu 
        755                 760                 765             


Gly His Leu Gly Lys Gly Leu Met Arg Lys Pro Pro Asp Ser Tyr Pro 
    770                 775                 780                 


Pro Lys Asp Asn Pro Arg Arg Leu Leu Gln Cys Gln Asn Val Asp Ile 
785                 790                 795                 800 


Ser Arg Pro Leu Asn Gly Leu Asn Val Pro Gln Pro Gln Ser Thr Gln 
                805                 810                 815     


Arg Val Leu Pro Pro Leu His Arg Ala Pro Arg Ala Pro Ser Val Pro 
            820                 825                 830         


Ala Arg Pro Leu Pro Ala Lys Pro Ala Leu Arg Gln Ala Gln Gly Thr 
        835                 840                 845             


Cys Lys Pro Asn Pro Pro Gln Lys Pro Leu Pro Ala Asp Pro Leu Ala 
    850                 855                 860                 


Arg Thr Thr Arg Leu Thr His Ala Leu Ala Arg Thr Pro Gly Gln Trp 
865                 870                 875                 880 


Glu Thr Gly Leu Arg Leu Ala Pro Leu Arg Pro Ala Pro Gln Tyr Pro 
                885                 890                 895     


His Gln Val Pro Arg Ser Thr His Thr Ala Tyr Ile Lys 
            900                 905                 


<210>  2612
<211>  3355
<212>  DNA
<213>  Homosapiens

<400>  2612
gactgctggc cgtggatcca tttcacaggc ctgccttctc tcactaacgc tcttcctagt     60

ccccgggcca actcggacag tttgctcatt tattgcaacg gtcaaggctg gcttgtgcca    120

gaacggcgcg cgcgcgcgca cgcacgcaca cacacggggg gaaacttttt taaaaatgaa    180

aggctagaag agctcagcgg cggcgcgggc gctgcgcgag ggctccggag ctgactcgcc    240

gaggcaggaa atccctccgg tcgcgacgcc cggccccggc tcggcgcccg cgtgggatgg    300

tgcagcgctc gccgccgggc ccgagagctg ctgcactgaa ggccggcgac gatggcagcg    360

cgcccgctgc ccgtgtcccc cgcccgcgcc ctcctgctcg ccctggccgg tgctctgctc    420

gcgccctgcg aggcccgagg ggtgagctta tggaaccaag gaagagctga tgaagttgtc    480

agtgcctctg ttgggagtgg ggacctctgg atcccagtga agagcttcga ctccaagaat    540

catccagaag tgctgaatat tcgactacaa cgggaaagca aagaactgat cataaatctg    600

gaaagaaatg aaggtctcat tgccagcagt ttcacggaaa cccactatct gcaagacggt    660

actgatgtct ccctcgctcg aaattacacg gtaattctgg gtcactgtta ctaccatgga    720

catgtacggg gatattctga ttcagcagtc agtctcagca cgtgttctgg tctcagggga    780

cttattgtgt ttgaaaatga aagctatgtc ttagaaccaa tgaaaagtgc aaccaacaga    840

tacaaactct tcccagcgaa gaagctgaaa agcgtccggg gatcatgtgg atcacatcac    900

aacacaccaa acctcgctgc aaagaatgtg tttccaccac cctctcagac atgggcaaga    960

aggcataaaa gagagaccct caaggcaact aagtatgtgg agctggtgat cgtggcagac   1020

aaccgagagt ttcagaggca aggaaaagat ctggaaaaag ttaagcagcg attaatagag   1080

attgctaatc acgttgacaa gttttacaga ccactgaaca ttcggatcgt gttggtaggc   1140

gtggaagtgt ggaatgacat ggacaaatgc tctgtaagtc aggacccatt caccagcctc   1200

catgaatttc tggactggag gaagatgaag cttctacctc gcaaatccca tgacaatgcg   1260

cagcttgtca gtggggttta tttccaaggg accaccatcg gcatggcccc aatcatgagc   1320

atgtgcacgg cagaccagtc tgggggaatt gtcatggacc attcagacaa tccccttggt   1380

gcagccgtga ccctggcaca tgagctgggc cacaatttcg ggatgaatca tgacacactg   1440

gacaggggct gtagctgtca aatggcggtt gagaaaggag gctgcatcat gaacgcttcc   1500

accgggtacc catttcccat ggtgttcagc agttgcagca ggaaggactt ggagaccagc   1560

ctggagaaag gaatgggggt gtgcctgttt aacctgccgg aagtcaggga gtctttcggg   1620

ggccagaagt gtgggaacag atttgtggaa gaaggagagg agtgtgactg tggggagcca   1680

gaggaatgta tgaatcgctg ctgcaatgcc accacctgta ccctgaagcc ggacgctgtg   1740

tgcgcacatg ggctgtgctg tgaagactgc cagctgaagc ctgcaggaac agcgtgcagg   1800

gactccagca actcctgtga cctcccagag ttctgcacag gggccagccc tcactgccca   1860

gccaacgtgt acctgcacga tgggcactca tgtcaggatg tggacggcta ctgctacaat   1920

ggcatctgcc agactcacga gcagcagtgt gtcacgctct ggggaccagg tgctaaacct   1980

gcccctggga tctgctttga gagagtcaat tctgcaggtg atccttatgg caactgtggc   2040

aaagtctcga agagttcctt tgccaaatgc gagatgagag atgctaaatg tggaaaaatc   2100

cagtgtcaag gaggtgccag ccggccagtc attggtacca atgccgtttc catagaaaca   2160

aacatccccc tgcagcaagg aggccggatt ctgtgccggg ggacccacgt gtacttgggc   2220

gatgacatgc cggacccagg gcttgtgctt gcaggcacaa agtgtgcaga tggaaaaatc   2280

tgcctgaatc gtcaatgtca aaatattagt gtctttgggg ttcacgagtg tgcaatgcag   2340

tgccacggca gaggggtgtg caacaacagg aagaactgcc actgcgaggc ccactgggca   2400

cctcccttct gtgacaagtt tggctttgga ggaagcacag acagcggccc catccggcaa   2460

gcagaagcaa ggcaggaagc tgcagagtcc aacagggagc gcggccaggg ccaggagccc   2520

gtgggatcgc aggagcatgc gtctactgcc tcactgacac tcatctgagc cctcccatga   2580

catggagacc gtgaccagtg ctgctgcaga ggaggtcacg cgtccccaag gcctcctgtg   2640

actggcagca ttgactctgt ggctttgcca tcgtttccat gacaacagac acaacacagt   2700

tctcggggct caggagggga agtccagcct accaggcacg tctgcagaaa cagtgcaagg   2760

aagggcagcg acttcctggt tgagcttctg ctaaaacatg gacatgcttc agtgctgctc   2820

ctgagagagt agcaggttac cactctggca ggccccagcc ctgcagcaag gaggaagagg   2880

actcaaaagt ctggcctttc actgagcctc cacagcagtg ggggagaagc aagggttggg   2940

cccagtgtcc cctttcccca gtgacacctc agccttggca gccctgatga ctggtctctg   3000

gctgcaactt aatgctctga tatggctttt agcatttatt atatgaaaat agcagggttt   3060

tagtttttaa tttatcagag accctgccac ccattccatc tccatccaag caaactgaat   3120

ggcaatgaaa caaactggag aagaaggtag gagaaagggc ggtgaactct ggctctttgc   3180

tgtggacatg cgtgaccagc agtactcagg tttgagggtt tgcagaaagc cagggaaccc   3240

acagagtcac caacccttca tttaacaagt aagaatgtta aaaagtgaaa acaatgtaag   3300

agcctaactc catcccccgt ggccattact gcataaaata gagtgcattt gaaat        3355


<210>  2613
<211>  738
<212>  PRT
<213>  Homosapiens

<400>  2613

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Glu Ala Arg Gln Glu Ala Ala Glu Ser Asn Arg Glu Arg Gly Gln Gly 
705                 710                 715                 720 


Gln Glu Pro Val Gly Ser Gln Glu His Ala Ser Thr Ala Ser Leu Thr 
                725                 730                 735     


Leu Ile 
        


<210>  2614
<211>  3097
<212>  DNA
<213>  Homosapiens

<400>  2614
attctgagcc tagccacaga ggtaaactcc ggacattttt ttctttcatg tcgccaaata     60

catccttgtc attaaaagac ctttgaaact gagtaaaatg gctttgaaac ctcagtagaa    120

tatgctcaaa ctgtctggag aaggattacg ggacagctac cacagtagaa gagatcaaat    180

tgcccttaaa aatctccagt ctgatgtcac agaggcaaaa tctgacttca ccaaggagac    240

cctggcatca caaaacacaa aaatgatttc atccatagtc atctcccaga tgattgatga    300

gaataagtca agagaaaaca gggcctcctt gcccctaccg tgtgccattg ctcagtctcg    360

tgcacatcac gccaagcaat ctctggctaa ccgcagcgga gtcaacattc acagagcatt    420

tgcgttactt ccgggcagat taggaatccc ggcaccgtca gatgagcgag gacctgaggc    480

agagctgccg cccaaagagg agagaccctg tgggggcccc cgcagagggt ttgcatccat    540

caccatcacg gccagacgcg tgggcccccc agcccgcgcc ctggtgtggg ggactgctgg    600

ggactctctg tgccccaagt gcagggctga ggacacactg ttccaggcgc ccccggctct    660

ggccaatggc gcccatccag gtcggcatca gagatctttt gcctgcacag agttctccag    720

aaacagctcc gtggtgcggc tgaaggttcc cgaggcccac actgggttgt gtgagagacg    780

caagtactgg gtcacccatg cagacgacaa agagaccagt ttttctccag acaccccact    840

gtcaggaaag agcccgctgg tgttcagttc ctgtgtccac ctcagggtgt ctcagcagtg    900

tccagattca atctattacg tagacaagtc tctctccgtc cccattgagc cacctcaaat    960

tgccagcccc aaaatgcaca gatccgtcct gtcgctcaac ctcaattgta gttcccacag   1020

attaacagca gatggagtag atggcctagt gaacagagag ccaataagcg aagccctgaa   1080

gcaggagctc ctggagggag accaggacct cgtaggccag cgctggaacc caggtttaca   1140

agaaagtcac ttgaaggaaa ccccatcgtt gaggcgggtg catttgggga ccggcgcttg   1200

tccttggagt ggttcttttc cattggaaaa cacagaattg gcaaatgtgg gagctaacca   1260

agtcactgta agaaaagggg aaaaggacca tacaactcat tgtcacgcca gcgatcatgc   1320

caaccaactg tccattcaca ttcctggctg gagttacagg gcagtacaca caaaagtatt   1380

ttctggaagc agcaagaggc aacaaggaga agtatgtatg actgtgtctg ctcctccagt   1440

ggaacagaag cccactagac atttccttcc cattggggat agctctccaa gcgatgactg   1500

tctgtctaga gacctttctg agcccacaga gagacgacat caaagcttcc tgaaacccag   1560

aatccttttt cctgggtttc tttgcccctt acaagatgta tgtgcatctc tgcaggaaga   1620

caatggtgtt cagatagaaa gcaagttccc caaaggagat tacacatgct gtgacttggt   1680

tgtaaaaata aaggaatgta agaagagtga ggaccccacc acacctgagc cctccccagc   1740

agcaccctcg ccagcacccc gcgatggagc agggagccct ggcctgtccg aagactgttc   1800

tgagtctcag caaacgcctg caagatcttt gaccttgcaa gaagcactgg aagttcgtaa   1860

gcctcagttc atttctcgct cacaagaacg gctgaagaag cttgaacaca tggtccagca   1920

gaggaaagcc cagcggaagg aggacctgag gcagaagcag agcctccttc ccatccgcac   1980

cagcaagaag cagttcacga ttccccatcc tctgagtgat aacttgttca aacccaaaga   2040

acggtgcatt tcagagaagg agatgcatat gcgatctaag agaatctatg ataacttgcc   2100

ggaagttaaa aagaaaaaag aagaacaaag gaaaagggtg atcttacaaa gtaacagact   2160

ccgtgccgaa gtcttcaaaa agcaattact ggaccagctc cttcaaagga atgcggtcta   2220

accacaggct gccctgctga ccacactacc tggacctggg aggacttcga atgctggata   2280

agccattaaa cttagcatta tcttcatcat gggaaaacac ttattttact ttcgattttt   2340

tttttccata aaggaaaaca tcacttcctg aattactgac ccaagccaaa cagaaacaat   2400

aaccctcgag aaaataggtc aacaatctgt tgtggggaaa ccacctccat gtaacccact   2460

ggatacagtc cccttaatgt ttttgcttct aaattgtacc ttttgcttct gatttcttct   2520

cccctgctgt ttcctgccca tcagagaggc ctgatacaag caagtttgtt tacatccctg   2580

gggaatcttt tacatcaaac ttttgggatc caaatccatc tccttttaaa tttcaatctc   2640

agcacctgcc agttatgcaa atgccaaaat gtgggtcatc atatagtata tttgaaacct   2700

ttctgaacat gtacaccacc caatgctaga ggctgacttg gaaaccggtg ggtgcaatgc   2760

ccgaggctgt ggaacaatca gcccatctct ttgtgacctg gagcagtcag agggccctca   2820

gtcaccccgc cccattcctc accagagaaa agaatccatt tctatggaag ctctgacgta   2880

acttcagtgt tttctacaat actcctcctg ccccgcccca ttaaaacagt tcttttgtta   2940

agaaatagcc taatggtcca actttgctgt ctgttcttcc aaatgtttat aatacacatt   3000

atttataaat atgtctgttt gggaagctaa gaacaagcta gtttttacaa cacaaatgga   3060

aataaatgca attattataa aaaaaaaaaa aaaaaaa                            3097


<210>  2615
<211>  699
<212>  PRT
<213>  Homosapiens

<400>  2615

Met Leu Lys Leu Ser Gly Glu Gly Leu Arg Asp Ser Tyr His Ser Arg 
1               5                   10                  15      


Arg Asp Gln Ile Ala Leu Lys Asn Leu Gln Ser Asp Val Thr Glu Ala 
            20                  25                  30          


Lys Ser Asp Phe Thr Lys Glu Thr Leu Ala Ser Gln Asn Thr Lys Met 
        35                  40                  45              


Ile Ser Ser Ile Val Ile Ser Gln Met Ile Asp Glu Asn Lys Ser Arg 
    50                  55                  60                  


Glu Asn Arg Ala Ser Leu Pro Leu Pro Cys Ala Ile Ala Gln Ser Arg 
65                  70                  75                  80  


Ala His His Ala Lys Gln Ser Leu Ala Asn Arg Ser Gly Val Asn Ile 
                85                  90                  95      


His Arg Ala Phe Ala Leu Leu Pro Gly Arg Leu Gly Ile Pro Ala Pro 
            100                 105                 110         


Ser Asp Glu Arg Gly Pro Glu Ala Glu Leu Pro Pro Lys Glu Glu Arg 
        115                 120                 125             


Pro Cys Gly Gly Pro Arg Arg Gly Phe Ala Ser Ile Thr Ile Thr Ala 
    130                 135                 140                 


Arg Arg Val Gly Pro Pro Ala Arg Ala Leu Val Trp Gly Thr Ala Gly 
145                 150                 155                 160 


Asp Ser Leu Cys Pro Lys Cys Arg Ala Glu Asp Thr Leu Phe Gln Ala 
                165                 170                 175     


Pro Pro Ala Leu Ala Asn Gly Ala His Pro Gly Arg His Gln Arg Ser 
            180                 185                 190         


Phe Ala Cys Thr Glu Phe Ser Arg Asn Ser Ser Val Val Arg Leu Lys 
        195                 200                 205             


Val Pro Glu Ala His Thr Gly Leu Cys Glu Arg Arg Lys Tyr Trp Val 
    210                 215                 220                 


Thr His Ala Asp Asp Lys Glu Thr Ser Phe Ser Pro Asp Thr Pro Leu 
225                 230                 235                 240 


Ser Gly Lys Ser Pro Leu Val Phe Ser Ser Cys Val His Leu Arg Val 
                245                 250                 255     


Ser Gln Gln Cys Pro Asp Ser Ile Tyr Tyr Val Asp Lys Ser Leu Ser 
            260                 265                 270         


Val Pro Ile Glu Pro Pro Gln Ile Ala Ser Pro Lys Met His Arg Ser 
        275                 280                 285             


Val Leu Ser Leu Asn Leu Asn Cys Ser Ser His Arg Leu Thr Ala Asp 
    290                 295                 300                 


Gly Val Asp Gly Leu Val Asn Arg Glu Pro Ile Ser Glu Ala Leu Lys 
305                 310                 315                 320 


Gln Glu Leu Leu Glu Gly Asp Gln Asp Leu Val Gly Gln Arg Trp Asn 
                325                 330                 335     


Pro Gly Leu Gln Glu Ser His Leu Lys Glu Thr Pro Ser Leu Arg Arg 
            340                 345                 350         


Val His Leu Gly Thr Gly Ala Cys Pro Trp Ser Gly Ser Phe Pro Leu 
        355                 360                 365             


Glu Asn Thr Glu Leu Ala Asn Val Gly Ala Asn Gln Val Thr Val Arg 
    370                 375                 380                 


Lys Gly Glu Lys Asp His Thr Thr His Cys His Ala Ser Asp His Ala 
385                 390                 395                 400 


Asn Gln Leu Ser Ile His Ile Pro Gly Trp Ser Tyr Arg Ala Val His 
                405                 410                 415     


Thr Lys Val Phe Ser Gly Ser Ser Lys Arg Gln Gln Gly Glu Val Cys 
            420                 425                 430         


Met Thr Val Ser Ala Pro Pro Val Glu Gln Lys Pro Thr Arg His Phe 
        435                 440                 445             


Leu Pro Ile Gly Asp Ser Ser Pro Ser Asp Asp Cys Leu Ser Arg Asp 
    450                 455                 460                 


Leu Ser Glu Pro Thr Glu Arg Arg His Gln Ser Phe Leu Lys Pro Arg 
465                 470                 475                 480 


Ile Leu Phe Pro Gly Phe Leu Cys Pro Leu Gln Asp Val Cys Ala Ser 
                485                 490                 495     


Leu Gln Glu Asp Asn Gly Val Gln Ile Glu Ser Lys Phe Pro Lys Gly 
            500                 505                 510         


Asp Tyr Thr Cys Cys Asp Leu Val Val Lys Ile Lys Glu Cys Lys Lys 
        515                 520                 525             


Ser Glu Asp Pro Thr Thr Pro Glu Pro Ser Pro Ala Ala Pro Ser Pro 
    530                 535                 540                 


Ala Pro Arg Asp Gly Ala Gly Ser Pro Gly Leu Ser Glu Asp Cys Ser 
545                 550                 555                 560 


Glu Ser Gln Gln Thr Pro Ala Arg Ser Leu Thr Leu Gln Glu Ala Leu 
                565                 570                 575     


Glu Val Arg Lys Pro Gln Phe Ile Ser Arg Ser Gln Glu Arg Leu Lys 
            580                 585                 590         


Lys Leu Glu His Met Val Gln Gln Arg Lys Ala Gln Arg Lys Glu Asp 
        595                 600                 605             


Leu Arg Gln Lys Gln Ser Leu Leu Pro Ile Arg Thr Ser Lys Lys Gln 
    610                 615                 620                 


Phe Thr Ile Pro His Pro Leu Ser Asp Asn Leu Phe Lys Pro Lys Glu 
625                 630                 635                 640 


Arg Cys Ile Ser Glu Lys Glu Met His Met Arg Ser Lys Arg Ile Tyr 
                645                 650                 655     


Asp Asn Leu Pro Glu Val Lys Lys Lys Lys Glu Glu Gln Arg Lys Arg 
            660                 665                 670         


Val Ile Leu Gln Ser Asn Arg Leu Arg Ala Glu Val Phe Lys Lys Gln 
        675                 680                 685             


Leu Leu Asp Gln Leu Leu Gln Arg Asn Ala Val 
    690                 695                 


<210>  2616
<211>  2141
<212>  DNA
<213>  Homosapiens

<400>  2616
ctacggggcg ggttccaccg cccagaagag cgcacggcgg gcgctgccgg ccccgagcgc     60

tcccgctacc actgccgctc ccggccctgc cggccggcca tgccccgagt tccggctgcc    120

gcgcgcaccc agacccggcg atgaggagtg gcgccgagcg caggggcagc agcgccgcgg    180

cgtccccggg ctcgccgccc cccggccgcg cgcgccccgc cggctccgac gcgccctcgg    240

ccctgccgcc gcccgctgct ggccagcccc gggcccggga ctcgggcgat gtccgctcgc    300

agccgcgccc cctgtttcag tggagcaagt ggaagaagag gatgggctcg tccatgtcgg    360

cggccaccgc gcggaggccg gtgtttgacg acaaggagga cgtgaacttc gaccacttcc    420

agatccttcg ggccattggg aagggcagct ttggcaaggt gtgcattgtg cagaagcggg    480

acacggagaa gatgtacgcc atgaagtaca tgaacaagca gcagtgcatc gagcgcgacg    540

aggtccgcaa cgtcttccgg gagctggaga tcctgcagga gatcgagcac gtcttcctgg    600

tgaacctctg gtactccttc caggacgagg aggacatgtt catggtcgtg gacctgctac    660

tgggcgggga cctgcgctac cacctgcagc agaacgtgca gttctccgag gacacggtga    720

ggctgtacat ctgcgagatg gcactggctc tggactacct gcgcggccag cacatcatcc    780

acagagatgt caagcctgac aacattctcc tggatgagag aggacatgca cacctgaccg    840

acttcaacat tgccaccatc atcaaggacg gggagcgggc gacggcatta gcaggcacca    900

agccgtacat ggctccggag atcttccact cttttgtcaa cggcgggacc ggctactcct    960

tcgaggtgga ctggtggtcg gtgggggtga tggcctatga gctgctgcga ggatggaggc   1020

cctatgacat ccactccagc aacgccgtgg agtccctggt gcagctgttc agcaccgtga   1080

gcgtccagta tgtccccacg tggtccaagg agatggtggc cttgctgcgg aagctcctca   1140

ctgtgaaccc cgagcaccgg ctctccagcc tccaggacgt gcaggcagcc ccggcgctgg   1200

ccggcgtgct gtgggaccac ctgagcgaga agagggtgga gccgggcttc gtgcccaaca   1260

aaggccgtct gcactgcgac cccacctttg agctggagga gatgatcctg gagtccaggc   1320

ccctgcacaa gaagaagaag cgtctggcca agaacaagtc ccgggacaac agcagggaca   1380

gctcccagtc cgagaatgac tatcttcaag actgcctcga tgccatccag caagacttcg   1440

tgatttttaa cagagaaaag ctgaagagga gccaggacct cccgagggag cctctccccg   1500

cccctgagtc cagggatgct gcggagcctg tggaggacga ggcggaacgc tccgccctgc   1560

ccatgtgcgg ccccatttgc ccctcggccg ggagcggcta ggccgggacg cccgtggtcc   1620

tcaccccttg agctgctttg gagactcggc tgccagaggg agggccatgg gccgaggcct   1680

ggcattcacg ttcccaccca gcctggctgg cggtgcccac agtgccccgg acacatttca   1740

cacctcaggc tcgtggtggt gcaggggaca agaggctgtg ggtgcagggg acacctgtgg   1800

agggcatttc ccgtgggccc ccgagacccg cctagatgga ggaagcgctg ctgggcgccc   1860

tcttaccgct cacggggagc tggggccatg gatgggacag gagtctttgt ccctgctcag   1920

cccggaggct gtgcacggcc ctcgtcacaa ggtgaccctt gcagcacagg ccgcgggtgc   1980

cccaggctcg gctcaggtct tggaggtcaa gggcatgggt tggggtagtg ggtggggagg   2040

tgaatgtttt ctagagattc aaactgctcc agcaatttct gtagttttca cctctgagaa   2100

ttacaatgtg agaaccgcta aaaaaaaaaa aaaaaaaaaa a                       2141


<210>  2617
<211>  486
<212>  PRT
<213>  Homosapiens

<400>  2617

Met Arg Ser Gly Ala Glu Arg Arg Gly Ser Ser Ala Ala Ala Ser Pro 
1               5                   10                  15      


Gly Ser Pro Pro Pro Gly Arg Ala Arg Pro Ala Gly Ser Asp Ala Pro 
            20                  25                  30          


Ser Ala Leu Pro Pro Pro Ala Ala Gly Gln Pro Arg Ala Arg Asp Ser 
        35                  40                  45              


Gly Asp Val Arg Ser Gln Pro Arg Pro Leu Phe Gln Trp Ser Lys Trp 
    50                  55                  60                  


Lys Lys Arg Met Gly Ser Ser Met Ser Ala Ala Thr Ala Arg Arg Pro 
65                  70                  75                  80  


Val Phe Asp Asp Lys Glu Asp Val Asn Phe Asp His Phe Gln Ile Leu 
                85                  90                  95      


Arg Ala Ile Gly Lys Gly Ser Phe Gly Lys Val Cys Ile Val Gln Lys 
            100                 105                 110         


Arg Asp Thr Glu Lys Met Tyr Ala Met Lys Tyr Met Asn Lys Gln Gln 
        115                 120                 125             


Cys Ile Glu Arg Asp Glu Val Arg Asn Val Phe Arg Glu Leu Glu Ile 
    130                 135                 140                 


Leu Gln Glu Ile Glu His Val Phe Leu Val Asn Leu Trp Tyr Ser Phe 
145                 150                 155                 160 


Gln Asp Glu Glu Asp Met Phe Met Val Val Asp Leu Leu Leu Gly Gly 
                165                 170                 175     


Asp Leu Arg Tyr His Leu Gln Gln Asn Val Gln Phe Ser Glu Asp Thr 
            180                 185                 190         


Val Arg Leu Tyr Ile Cys Glu Met Ala Leu Ala Leu Asp Tyr Leu Arg 
        195                 200                 205             


Gly Gln His Ile Ile His Arg Asp Val Lys Pro Asp Asn Ile Leu Leu 
    210                 215                 220                 


Asp Glu Arg Gly His Ala His Leu Thr Asp Phe Asn Ile Ala Thr Ile 
225                 230                 235                 240 


Ile Lys Asp Gly Glu Arg Ala Thr Ala Leu Ala Gly Thr Lys Pro Tyr 
                245                 250                 255     


Met Ala Pro Glu Ile Phe His Ser Phe Val Asn Gly Gly Thr Gly Tyr 
            260                 265                 270         


Ser Phe Glu Val Asp Trp Trp Ser Val Gly Val Met Ala Tyr Glu Leu 
        275                 280                 285             


Leu Arg Gly Trp Arg Pro Tyr Asp Ile His Ser Ser Asn Ala Val Glu 
    290                 295                 300                 


Ser Leu Val Gln Leu Phe Ser Thr Val Ser Val Gln Tyr Val Pro Thr 
305                 310                 315                 320 


Trp Ser Lys Glu Met Val Ala Leu Leu Arg Lys Leu Leu Thr Val Asn 
                325                 330                 335     


Pro Glu His Arg Leu Ser Ser Leu Gln Asp Val Gln Ala Ala Pro Ala 
            340                 345                 350         


Leu Ala Gly Val Leu Trp Asp His Leu Ser Glu Lys Arg Val Glu Pro 
        355                 360                 365             


Gly Phe Val Pro Asn Lys Gly Arg Leu His Cys Asp Pro Thr Phe Glu 
    370                 375                 380                 


Leu Glu Glu Met Ile Leu Glu Ser Arg Pro Leu His Lys Lys Lys Lys 
385                 390                 395                 400 


Arg Leu Ala Lys Asn Lys Ser Arg Asp Asn Ser Arg Asp Ser Ser Gln 
                405                 410                 415     


Ser Glu Asn Asp Tyr Leu Gln Asp Cys Leu Asp Ala Ile Gln Gln Asp 
            420                 425                 430         


Phe Val Ile Phe Asn Arg Glu Lys Leu Lys Arg Ser Gln Asp Leu Pro 
        435                 440                 445             


Arg Glu Pro Leu Pro Ala Pro Glu Ser Arg Asp Ala Ala Glu Pro Val 
    450                 455                 460                 


Glu Asp Glu Ala Glu Arg Ser Ala Leu Pro Met Cys Gly Pro Ile Cys 
465                 470                 475                 480 


Pro Ser Ala Gly Ser Gly 
                485     


<210>  2618
<211>  6382
<212>  DNA
<213>  Homosapiens

<400>  2618
ggctgctgct ctcagcggcg gggctcgcca gcgcttcagt gggcggggac gcggcaggtg     60

actccagacc aaggaggatg agctgctgtc cctggaagag aacggatgga gggaagcagc    120

tcctacgaag ttccctctgt ggctgctgct gatctggagg agggtgctgg tcagactagg    180

agcttgcctg ccaccccctc caaagatgtt cacaagggtg ttggaggcat catcttttcc    240

tcctcaccga ttttagactt gagtgaaagt ggtctgtgcc gtttggagga ggtctttaga    300

atccccagcc ttcaacaatt gcatctgcaa aggaatgccc tgtgtgtgat tcctcaagat    360

ttctttcagt tgcttccgaa cctgacttgg ctggacctcc ggtacaatag aattaaagcg    420

cttccttctg ggattggagc tcaccagcat ttgaaaactt tgcttttaga aagaaatcct    480

atcaaaatgt tacctgtgga gctggggagc gtaaccacgc tgaaagcact gaacctaaga    540

cactgccctc tggaattccc tcctcagctc gttgtgcaga agggattggt ggctatccag    600

cgcttcctgc ggatgtgggc agtagaacac tctctcccca gaaatccaac ttctcaagag    660

gctccaccgg ttagagagat gaccctccgt gacctcccga gcccaggact ggagttgtct    720

ggagaccacg cgtctaacca aggagctgtg aacgctcagg acccagaggg ggctgtgatg    780

aaagagaagg ccagctttct cccacctgtg gaaaagccag acctgagtga actcaggaag    840

tctgcggact cctcagagaa ctggcccagc gaggaggaga tcaggcgctt ttggaagctg    900

aggcaggaga ttgttgagca cgtgaaggca gacgttctgg gagatcagct cttgacgagg    960

gaattacctc caaatctcaa ggcggccttg aacattgaga aagaactacc aaagccaaga   1020

cacgttttca gaaggaagac agcctcctcc aggagcatct tacccgacct cttgtcaccg   1080

taccaaatgg cgatccgagc aaaaagactg gaagagagcc gagcggcggc gctccgagag   1140

ctccaggaga agcaggctct gatggagcag cagagacgag agaaaagggc actgcaggag   1200

tggagagagc gagcccagag gatgaggaag aggaaggaag agctcagcaa actcctgcct   1260

ccgcggagga gcatggtggc atcaaagatt ccctctgcca cagatctgat agataacagg   1320

aaagtaccac tgaatccgcc tggaaaaatg aaaccaagca aagagaaatc gccacaagca   1380

agtaaagaaa tgagtgccct gcaggagaga aatttagaag agaagataaa acagcacgtc   1440

ctccaaatgc gtgagcaaag aagattccat ggccaggccc cactggagga gatgaggaag   1500

gctgccgagg atctggaaat tgccacagag ctacaggatg aagtattgaa gctaaaattg   1560

ggattaacct tgaacaaaga tcgtcgacgg gcggccctca ctggaaacct ttcgcttggc   1620

ctgccggcag cacagcctca aaatacattt tttaacacaa aatatggaga atcaggaaat   1680

gttcgcagat accagtgaca ccaggtggct ggactgatgg agacgtcttc agacaggagc   1740

cgctcagtct tctttcccgg gcgtcgcctc ctgtgtggtg ccggaagagc gccaggttca   1800

gtgttaccct gagggctgat ttcgcgcagc ctgttgtttt ccttagacag gtccacgtcc   1860

ctctcctgag gctgtggaag atttcagccg tattaaaaga aaggacactg tgagcacgtg   1920

gtctcgcctt cccttcttcc tgcaggttcc cgccaagcca tgtgacagag tgctcacact   1980

caggcacttg cctctctcct gtcctggagc ccttgttaca aaagtactca cagctttcct   2040

tcacttagtt atttgagtgt gggagaggag accaggtcac ccgattcccg ccaagccgga   2100

agtccctgca gcaccacctt tggctaggag ggaggggtga cagccaaaaa gggcttcggg   2160

ggagtggtta ccctgctccc tgcccagtga caagccctcc tttcccctgg gggccctcct   2220

ttcccctgct ccctgcccag ctacggggcc ctcctttcag ccttgacccc ttcctggttg   2280

ctaccactca ggctgccact cagtggactc caccccaggg acacggcagg gtctgcagac   2340

ctccccatgc tagatcagcc gtatttcatg ctctgtctgc ccaggctgtg tagattctgt   2400

gtgacttagt ctcttgtgct gagtgtttgc ttggatcttg aaaacatctt tggtttgatt   2460

tctttaacag aggtgagact attcagactt tgtttatttt tgtgttaatt ttggtaaata   2520

tggtttcagt gagtttcctc atttcatcca agttgtgcaa tgtatcagca taaagttcct   2580

cttattttca gtatctttag gatccgtaat aatgtcccct cttttattct tgacctggtg   2640

ttcttcatca ttcttgctat ggatttatca attttgttcc tcttttccaa aagccccagg   2700

ttttggcttc actggatttg ctgtttgtct tctgtctcat gggtctctgc gccctgcact   2760

tcgtactttc cgagagttta actggtgctt agagagaaat gcatcacttc caaacccatg   2820

tattagagaa gaagggcgtg aaatttatca cctaagcttt ccattcagga agctagaaaa   2880

ggtgtcagtg acctgttgcg gcccagcggc tggagcagca gacgtttgcc atttctcacg   2940

cctgagggca ggcgttggag cagctcagcc ggcgttgctg gtcagggtct cccgtgaggc   3000

tggagtcagc cgtgggttga gctgctctcc tctgaaggtt taactgggct tggggctcag   3060

cttccaaggt gctcacctgg ttgttgatca gagagcgtgt ccgttgtgat cccagtcctt   3120

tgaaactgtg aagcctcgcc ccgcggcctg ccgcaggata tgttttggta aatgtagact   3180

gtgcacttga gaagaatgta ttttgagttg ttgggtacat tgttttgtgt gtgtcaggtg   3240

acattgacta atcctgttgc tcagagctcc tgtaccctta ctgactgact taagcctggt   3300

ttctcagtta ctgagagagg cctgtgaaca gttctagcta tgatcatgaa catgtgtttt   3360

cttcttagtt atgtgagttt ttgctatacg tgttttgggg ctattttgtc agatgcctac   3420

aaatttagga ttgttttatc ttcctgtcga actgaccttg tcattattat gaactatttc   3480

tcttcgcctc tccttttcac ttcttgcctt ctgtggattt tgtctgatac taatccaggc   3540

acactgctgc tgttttggtc agcgttttca taatgcatct tcttccctcc ttctactgta   3600

ctggatttaa agcgcacctt atagagacat catatactcg ggactccttt tctttctcta   3660

gctgccagtt ctgtgtttca gttacagtgt ttggccctca catttaaggt gcgtgtgcgt   3720

acggcggatt ccgtgcccat ctcatgtttt tattcccttt attcttcttt tgctgctttc   3780

tgatagtgat caattttttt atttatatct cttgtattag agttttagta atatctttta   3840

atattattct cttgggtgtt gccttagaga tttcatacat gcccttgagt tcattagcat   3900

ttcctgaatg agccaatgac cctgagaagg tccctcccat ctgccagttc cctgcccttg   3960

atgctgttgc tctcgtccgc ctcccttcca caggtaagca cgcaagacac aggtaccgtg   4020

tgccccaacg gtgtcttgac tcgctgttcc tagacatcag tgtttgcttc actttaccca   4080

tcccgatgct cttccttcct gcagcttcat gctccaatga gggctgattt tcatttagct   4140

aaataacttt tttttaagta tttctttgta tcatggttat gctttgactg gccgtaagtt   4200

ctctcagctt ttgtttgtct gaaaataaat ttagttcgcc tttattctgc acaggacaga   4260

attctaggtg gatgattttt gccattccca gaactttaaa gatgggctcc actgtcttct   4320

ggctcccatg tgttttgtta aaaattcagt gttcaggccg ggtgctgtgg ctcacgcctg   4380

taatcccagc actttgggag gccgaggcga gtggatcacg aggtcaggag atcgagacca   4440

tcctggctaa cacggtgaaa ccccgtctct actaaaaaat acaaaaaatt agccgggcgt   4500

ggtggcaggc acctgtagtc gcagctactc aggaggctga ggcgggagaa tggcgtgaac   4560

ccaggagacg gagcttgcag tgagccgaga tcgcgccact gcactccagc ctgggcgaca   4620

gagcgagact ccgtctcaaa aaaaaaaaaa aaaagattca atgttcattg ttatttgttg   4680

ctcctttgaa ggtaatgtgt cttttttctt tgtcttaaaa ttgtttctcc ttatctttgg   4740

ttttcagcag tctgtgctgt gcctggatgt gattttcttt ttacgtattt ttcttggaat   4800

atacagaact caaatctggg agttagcatc tttcatcagt tttggaaaat tcttagccat   4860

tttttttttt tttactattt tttcccctgt tctccctctt ctccctgaga cttcagtttt   4920

gtgtgtgtgt gcacatgtat gtatgcattc gtgcgtacga gtgtgtgcat gtgtgcgccc   4980

gtgtgtatgt gcatatgtga gtgtgtgtgg ctgtaacctg cacgtctctt ctgtcatgtg   5040

ttctattttt cattcctctc tgtacatcag gctagatgcc tcctgtctac gtggttttag   5100

atttacgaat cctgtcttct gttgtgtccc acagaaaaac ccatgaggtt ttttaacatt   5160

aaaaacagca gctttatgat agagaaaaaa acacaaacat agacgattgt accattgcac   5220

tcagaagaaa catcccaggc cctgagcagc gtgtctttcc tcggccgagt caggcttcct   5280

ggtgagcctc agggagtgca tggtctcaga tgccatcctt ctcttctcca gcatttccac   5340

tcacctccgt gttcttgggg agtgcgtggt gtcagatccc atcctgctcc tctccagagt   5400

ttccggtcac ctccgtgttc tcagggagtg cgtggtcttg gatgccatcc tgctcatctc   5460

cagcatttcc tctcacctcc gtgttctcgg ggagtgcgtg gtgtcagatc ccatcctgct   5520

catctccagc atttcctctc acctctgtgt tctcggggag tgcgtggtgt cagatcccat   5580

cctgctcctc tccagcattt cctctcacct ccgtgttctc ggggagtgcg tggtgtcaga   5640

tcccatcctg ctcctctcca gagtttcctc tcacctccgt gttctcgggg agtgcgtggt   5700

ctcagatccc atcctgctcc tctccagagt ttcctctcac ctccgtgttc tcagggagtg   5760

cgtggtcttg gatgccatcc tgctcatctc cagcatttcc tctcacctcc gtgttctcgg   5820

ggagtgcgtg gtgtcagatc ccatcctgct cctctccagc atttcctctc acctccgagc   5880

tctcggggag tgcgtggtct cagatcccat cctgctcctc tccagagttt cctctcacct   5940

ccgtgttctc gttctcatct ctgccggaat tccacatctg ctcgtgcatg ccatccacct   6000

tttccactag atccttttac atcatcatta taatgatttt tttttaataa gtgttttctt   6060

tcagttttaa atttcagatg ttgtgttttt caggtctaag gtgtctggta attttttgtg   6120

gatgccgatt ctctgttgaa attctccatc ttttcatttc ctttatatct cttttcttct   6180

tttttctata atatattaca tttttctaat aagtttttag tgagtgtcca gcattgtata   6240

agttgaccct tgaacaagag tttgaattat aagggtccac ttataagtgg atttttaaaa   6300

aaatatatat tgcaaaaatt tttggaaatt tgcaacaatt tgaaaaactt tgcagatgag   6360

ccacatagcc tagaaatatc tg                                            6382


<210>  2619
<211>  530
<212>  PRT
<213>  Homosapiens

<400>  2619

Met Glu Gly Ser Ser Ser Tyr Glu Val Pro Ser Val Ala Ala Ala Asp 
1               5                   10                  15      


Leu Glu Glu Gly Ala Gly Gln Thr Arg Ser Leu Pro Ala Thr Pro Ser 
            20                  25                  30          


Lys Asp Val His Lys Gly Val Gly Gly Ile Ile Phe Ser Ser Ser Pro 
        35                  40                  45              


Ile Leu Asp Leu Ser Glu Ser Gly Leu Cys Arg Leu Glu Glu Val Phe 
    50                  55                  60                  


Arg Ile Pro Ser Leu Gln Gln Leu His Leu Gln Arg Asn Ala Leu Cys 
65                  70                  75                  80  


Val Ile Pro Gln Asp Phe Phe Gln Leu Leu Pro Asn Leu Thr Trp Leu 
                85                  90                  95      


Asp Leu Arg Tyr Asn Arg Ile Lys Ala Leu Pro Ser Gly Ile Gly Ala 
            100                 105                 110         


His Gln His Leu Lys Thr Leu Leu Leu Glu Arg Asn Pro Ile Lys Met 
        115                 120                 125             


Leu Pro Val Glu Leu Gly Ser Val Thr Thr Leu Lys Ala Leu Asn Leu 
    130                 135                 140                 


Arg His Cys Pro Leu Glu Phe Pro Pro Gln Leu Val Val Gln Lys Gly 
145                 150                 155                 160 


Leu Val Ala Ile Gln Arg Phe Leu Arg Met Trp Ala Val Glu His Ser 
                165                 170                 175     


Leu Pro Arg Asn Pro Thr Ser Gln Glu Ala Pro Pro Val Arg Glu Met 
            180                 185                 190         


Thr Leu Arg Asp Leu Pro Ser Pro Gly Leu Glu Leu Ser Gly Asp His 
        195                 200                 205             


Ala Ser Asn Gln Gly Ala Val Asn Ala Gln Asp Pro Glu Gly Ala Val 
    210                 215                 220                 


Met Lys Glu Lys Ala Ser Phe Leu Pro Pro Val Glu Lys Pro Asp Leu 
225                 230                 235                 240 


Ser Glu Leu Arg Lys Ser Ala Asp Ser Ser Glu Asn Trp Pro Ser Glu 
                245                 250                 255     


Glu Glu Ile Arg Arg Phe Trp Lys Leu Arg Gln Glu Ile Val Glu His 
            260                 265                 270         


Val Lys Ala Asp Val Leu Gly Asp Gln Leu Leu Thr Arg Glu Leu Pro 
        275                 280                 285             


Pro Asn Leu Lys Ala Ala Leu Asn Ile Glu Lys Glu Leu Pro Lys Pro 
    290                 295                 300                 


Arg His Val Phe Arg Arg Lys Thr Ala Ser Ser Arg Ser Ile Leu Pro 
305                 310                 315                 320 


Asp Leu Leu Ser Pro Tyr Gln Met Ala Ile Arg Ala Lys Arg Leu Glu 
                325                 330                 335     


Glu Ser Arg Ala Ala Ala Leu Arg Glu Leu Gln Glu Lys Gln Ala Leu 
            340                 345                 350         


Met Glu Gln Gln Arg Arg Glu Lys Arg Ala Leu Gln Glu Trp Arg Glu 
        355                 360                 365             


Arg Ala Gln Arg Met Arg Lys Arg Lys Glu Glu Leu Ser Lys Leu Leu 
    370                 375                 380                 


Pro Pro Arg Arg Ser Met Val Ala Ser Lys Ile Pro Ser Ala Thr Asp 
385                 390                 395                 400 


Leu Ile Asp Asn Arg Lys Val Pro Leu Asn Pro Pro Gly Lys Met Lys 
                405                 410                 415     


Pro Ser Lys Glu Lys Ser Pro Gln Ala Ser Lys Glu Met Ser Ala Leu 
            420                 425                 430         


Gln Glu Arg Asn Leu Glu Glu Lys Ile Lys Gln His Val Leu Gln Met 
        435                 440                 445             


Arg Glu Gln Arg Arg Phe His Gly Gln Ala Pro Leu Glu Glu Met Arg 
    450                 455                 460                 


Lys Ala Ala Glu Asp Leu Glu Ile Ala Thr Glu Leu Gln Asp Glu Val 
465                 470                 475                 480 


Leu Lys Leu Lys Leu Gly Leu Thr Leu Asn Lys Asp Arg Arg Arg Ala 
                485                 490                 495     


Ala Leu Thr Gly Asn Leu Ser Leu Gly Leu Pro Ala Ala Gln Pro Gln 
            500                 505                 510         


Asn Thr Phe Phe Asn Thr Lys Tyr Gly Glu Ser Gly Asn Val Arg Arg 
        515                 520                 525             


Tyr Gln 
    530 


<210>  2620
<211>  2624
<212>  DNA
<213>  Homosapiens

<400>  2620
ggggacggcc tgggacgcgg cgggagcatg gagccgcgcg ccggctgccg gctgccggtg     60

cgggtggagc aggtcgtcaa cggcgcgctg gtggtcacgg tgagctgcgg cgagcggagc    120

ttcgcgggga tcctgctgga ctgcacgaaa aagtccggcc tctttggcct acccccgttg    180

gctccgctgc cccaggtcga tgagtcccct gtcaacgaca gccatggccg ggctcccgag    240

gagggggatg cagaggtgat gcagctgggg tccagctccc cccctcctgc ctgcggggtt    300

cagccccccg agaccaccgg ccccgagcca cccccgcccc tcgtgccgcc gctgcccgcc    360

ggaagcctgc ccccgtaccc tccctacttc gaaggcgccc ccttccctca cccgctgtgg    420

ctccgggaca cgtacaagct gtgggtgccc cagccgccgc ccaggaccat caagcgcacg    480

cggcggcgtc tgtcccgcaa ccgcgacccg gggcgcctca tcctcagcac catccgcctg    540

cggccgcgcc aggtgctctg tgagaagtgc aagagcacgc tgagcccccc ggaggccagc    600

cccggacccc cagccgcgcc cagggcccgc aggaggctgg gcagcggccc ggacagggag    660

ctccgcaagc cggaggagcc ggagaacggc gagcccacgg ctgcggccac cgccaggagg    720

agcaagaggg agaggcgcga ggaggacagg gccccggcag agcaggtccc gcggagcccg    780

gtcatcaaga tctcctacag cacgccccag ggcaagggag aggtggtcaa gatcccctcc    840

cgcgtgcacg gctctctgga gcccttccgt ccccagcagg ccccgcagga cgacggcagc    900

caggaccccg aggtgctgga cagagagtcc cgggaccggc cgtcctgcgc gccctcggcc    960

tccatcccca agttgaaact gacacggcct gtgccggccg gcgcggacct gccgccccct   1020

aagatccgcc tgaagcccca ccgtctgggg gacagcgagc acgagcccgt gtaccgggcc   1080

gagctggtgg gggagctgaa cgggtacctg cgggacagct cgccggcgcc ctgtgcggac   1140

ggccctgccg gtgggctggc ggacttgtct tctggaagtt cgggtgagga cgatgacttc   1200

aagagctgtc cccagggtcc acagggacgc gagggcttgg cttttctcgt cagctgccct   1260

gaggggagag cggactgtgc cagtgagtcg gcgtgcagca gcgacagcct ggacgaggcc   1320

agatcgtccg gctcggaagg gacgccggca gacacgggtg acctctcgcc tggccacggc   1380

gcgtcagcgc cctcggtgtc cagagaggct cgccaaacgg tgccgcccct gacggtcagg   1440

ctgcacacac agagcgtgtc ggagtgcatc acggaggacg gcaggactgt ggccgtgggg   1500

gacatcgtct ggggtaagat ccatggtttt ccttggtggc cggcgcgtgt tcttgacatc   1560

agtctcggcc agaaggagga cggagagccg tcttggcgag aagcgaaggt ctcgtggttt   1620

ggttctccga ctacgtcgtt cttgtctatt tcaaaactct cccctttctc tgaatttttc   1680

aaactgagat ttaatcgtaa gaagaagggg atgtatcgga aagctataac cgaggctgca   1740

aatgccgcaa gacacgtggc cccggaaatc agggagctct taacccagtt tgaaacgtaa   1800

ctggttccct gaccaggtca ccgacgatga gggcgcacct gctgtcctgg agcttccgat   1860

ctctgttcgg ggaccctgtg agccttctgg ccggctgcgt gcagagccca ctgggcacgg   1920

tggtcggcct ggtgtgaggc cccccgggga ccggcagtgt gtccagggag gggatggccc   1980

tgagcccagc ggctcctccc gctgagtgta tttcttccca ccactcagcg catggctgcc   2040

ctggctcacg aggcagtcgg gactcgtgac ttgctggctg ctggctgctg ctgcctcgcg   2100

cgctggggtt ccatggagga actgggcctg ccgccccggc ctcacctgct gcccgcatgc   2160

tggggtccca tggaggaacc aggcctggcg ccccggcctc gcccagcggc tggtgtgggc   2220

agctgttccc tgcctcgcag tgtcctggag gcagctgtct cgcagactca gcttggtctc   2280

ccgcaggctt cagaaaaacc caattgcacg tgtgggattc ttccccagcc cttgggtgcg   2340

gggtctctgt gcacttgaga gctgggggac ccacccaccg tctcccactc caagttcatc   2400

ccagagcgtg gggcccgctg ggcacctggc acctggcctg cagatgctgc tacgagtgac   2460

cagtgctgtg tggaggaggc caagggcggc ccctgggaaa ccgggcttca acagtacaag   2520

gaaaagaaac ttgctctgtt ttgtaagagc gtgttccttt tcctcttttt tgtcacttta   2580

aagaccaaaa agaataaaga aagaaaagaa aaaaaaaaaa aaaa                    2624


<210>  2621
<211>  513
<212>  PRT
<213>  Homosapiens

<400>  2621

Met Gln Leu Gly Ser Ser Ser Pro Pro Pro Ala Cys Gly Val Gln Pro 
1               5                   10                  15      


Pro Glu Thr Thr Gly Pro Glu Pro Pro Pro Pro Leu Val Pro Pro Leu 
            20                  25                  30          


Pro Ala Gly Ser Leu Pro Pro Tyr Pro Pro Tyr Phe Glu Gly Ala Pro 
        35                  40                  45              


Phe Pro His Pro Leu Trp Leu Arg Asp Thr Tyr Lys Leu Trp Val Pro 
    50                  55                  60                  


Gln Pro Pro Pro Arg Thr Ile Lys Arg Thr Arg Arg Arg Leu Ser Arg 
65                  70                  75                  80  


Asn Arg Asp Pro Gly Arg Leu Ile Leu Ser Thr Ile Arg Leu Arg Pro 
                85                  90                  95      


Arg Gln Val Leu Cys Glu Lys Cys Lys Ser Thr Leu Ser Pro Pro Glu 
            100                 105                 110         


Ala Ser Pro Gly Pro Pro Ala Ala Pro Arg Ala Arg Arg Arg Leu Gly 
        115                 120                 125             


Ser Gly Pro Asp Arg Glu Leu Arg Lys Pro Glu Glu Pro Glu Asn Gly 
    130                 135                 140                 


Glu Pro Thr Ala Ala Ala Thr Ala Arg Arg Ser Lys Arg Glu Arg Arg 
145                 150                 155                 160 


Glu Glu Asp Arg Ala Pro Ala Glu Gln Val Pro Arg Ser Pro Val Ile 
                165                 170                 175     


Lys Ile Ser Tyr Ser Thr Pro Gln Gly Lys Gly Glu Val Val Lys Ile 
            180                 185                 190         


Pro Ser Arg Val His Gly Ser Leu Glu Pro Phe Arg Pro Gln Gln Ala 
        195                 200                 205             


Pro Gln Asp Asp Gly Ser Gln Asp Pro Glu Val Leu Asp Arg Glu Ser 
    210                 215                 220                 


Arg Asp Arg Pro Ser Cys Ala Pro Ser Ala Ser Ile Pro Lys Leu Lys 
225                 230                 235                 240 


Leu Thr Arg Pro Val Pro Ala Gly Ala Asp Leu Pro Pro Pro Lys Ile 
                245                 250                 255     


Arg Leu Lys Pro His Arg Leu Gly Asp Ser Glu His Glu Pro Val Tyr 
            260                 265                 270         


Arg Ala Glu Leu Val Gly Glu Leu Asn Gly Tyr Leu Arg Asp Ser Ser 
        275                 280                 285             


Pro Ala Pro Cys Ala Asp Gly Pro Ala Gly Gly Leu Ala Asp Leu Ser 
    290                 295                 300                 


Ser Gly Ser Ser Gly Glu Asp Asp Asp Phe Lys Ser Cys Pro Gln Gly 
305                 310                 315                 320 


Pro Gln Gly Arg Glu Gly Leu Ala Phe Leu Val Ser Cys Pro Glu Gly 
                325                 330                 335     


Arg Ala Asp Cys Ala Ser Glu Ser Ala Cys Ser Ser Asp Ser Leu Asp 
            340                 345                 350         


Glu Ala Arg Ser Ser Gly Ser Glu Gly Thr Pro Ala Asp Thr Gly Asp 
        355                 360                 365             


Leu Ser Pro Gly His Gly Ala Ser Ala Pro Ser Val Ser Arg Glu Ala 
    370                 375                 380                 


Arg Gln Thr Val Pro Pro Leu Thr Val Arg Leu His Thr Gln Ser Val 
385                 390                 395                 400 


Ser Glu Cys Ile Thr Glu Asp Gly Arg Thr Val Ala Val Gly Asp Ile 
                405                 410                 415     


Val Trp Gly Lys Ile His Gly Phe Pro Trp Trp Pro Ala Arg Val Leu 
            420                 425                 430         


Asp Ile Ser Leu Gly Gln Lys Glu Asp Gly Glu Pro Ser Trp Arg Glu 
        435                 440                 445             


Ala Lys Val Ser Trp Phe Gly Ser Pro Thr Thr Ser Phe Leu Ser Ile 
    450                 455                 460                 


Ser Lys Leu Ser Pro Phe Ser Glu Phe Phe Lys Leu Arg Phe Asn Arg 
465                 470                 475                 480 


Lys Lys Lys Gly Met Tyr Arg Lys Ala Ile Thr Glu Ala Ala Asn Ala 
                485                 490                 495     


Ala Arg His Val Ala Pro Glu Ile Arg Glu Leu Leu Thr Gln Phe Glu 
            500                 505                 510         


Thr 
    


<210>  2622
<211>  738
<212>  DNA
<213>  Homosapiens

<400>  2622
aagggaggca ggaggcttct ctgggtataa agcagctgaa atgtggagtt tcctcccagg     60

agctgagagc gtgtccatgg gcccagtgcc tggcgtgtcc tccctgggag cttgctggac    120

gcatgaccag gattctggga gggcagagga cagaccacag gcacccagga taactcagta    180

cacatgggtt ctcagcttcc tgttcacaga gaaacctcag acaagaagca cgtcgcccat    240

ttctcatcaa ggccaacccc agaccacgag agcgctttct ctgcgtcagc cccagcaccc    300

cagcgcccct gcctccgggc gcccgcggcc tccgcactcc agtggcccag acctggctga    360

ggcagctccc gtggtagatc aagcctcaca ggcggctgga agagccagtt ctgggctggg    420

cctgtgggaa caggcgtctg ttagtcaggg tttcaggaat gcggccttcg aagcctgaag    480

cggggaatgg cggctctggg ccctcaaggg gcaggcggtg agcctgggag gccaggccgg    540

gctgacccaa ggggagagga ccctctccgc ccactgccgc tggccctggg caggtctaga    600

gcctgggggt ctccagaggc acaatccctt atctccggga gaaggcagag ggcagaggca    660

ggaaacaaat ctcctgtcaa aattcctaat taaaatacta agtaagtgat ggctccaggc    720

tgaaacaccg gacactga                                                  738


<210>  2623
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  2623

Met Trp Ser Phe Leu Pro Gly Ala Glu Ser Val Ser Met Gly Pro Val 
1               5                   10                  15      


Pro Gly Val Ser Ser Leu Gly Ala Cys Trp Thr His Asp Gln Asp Ser 
            20                  25                  30          


Gly Arg Ala Glu Asp Arg Pro Gln Ala Pro Arg Ile Thr Gln Tyr Thr 
        35                  40                  45              


Trp Val Leu Ser Phe Leu Phe Thr Glu Lys Pro Gln Thr Arg Ser Thr 
    50                  55                  60                  


Ser Pro Ile Ser His Gln Gly Gln Pro Gln Thr Thr Arg Ala Leu Ser 
65                  70                  75                  80  


Leu Arg Gln Pro Gln His Pro Ser Ala Pro Ala Ser Gly Arg Pro Arg 
                85                  90                  95      


Pro Pro His Ser Ser Gly Pro Asp Leu Ala Glu Ala Ala Pro Val Val 
            100                 105                 110         


Asp Gln Ala Ser Gln Ala Ala Gly Arg Ala Ser Ser Gly Leu Gly Leu 
        115                 120                 125             


Trp Glu Gln Ala Ser Val Ser Gln Gly Phe Arg Asn Ala Ala Phe Glu 
    130                 135                 140                 


Ala 
145 


<210>  2624
<211>  2938
<212>  DNA
<213>  Homosapiens

<400>  2624
gcgcgggccg ctgtgaggcg cggcggcgag cgacgggcgc ggggccgcgg agcagcgagc     60

gagcgagcga gcgcgaggcc ggagccccgg ccaggcccgg ccgacccgcc gagcccgcga    120

tgcgccccgg ggccgccccc cggcgcagct gacgccccgc ggccccgcga agaccccggc    180

cggccggtcc cggaggaagc ggccgccgcc gccgccgccc agcccagcgc ccgcgccgcc    240

cgggcaccat ggcggggaag gcggccgccc cgggcaccgc ggtgctgctg gtcacggcca    300

acgtgggctc gctcttcgac gacccagaaa acctgcagaa gaactggctt cgggaatttt    360

accaggtcgt gcacacacac aagccgcact tcatggcctt gcactgtcag gagtttggag    420

ggaagaacta cgaggcctcc atgtcccacg tggacaagtt cgtcaaagaa ctattgtcga    480

gtgatgcgat gaaagaatat aacagggctc gagtctacct ggatgaaaac tacaaatccc    540

aggagcactt cacggcacta ggaagctttt attttcttca tgagtcctta aaaaacatct    600

accagtttga ctttaaagct aagaagtata gaaaggtcgc tggcaaagag atctactcgg    660

ataccttaga gagcacgccc atgctggaga aggagaagtt tccgcaggac tacttccccg    720

agtgcaaatg gtcaagaaaa ggcttcatcc ggacgaggtg gtgcattgca gactgtgcct    780

ttgacttggt gaatatccat cttttccatg atgcttccaa tctggtcgcc tgggaaacaa    840

gcccttccgt gtactcggga atccggcaca aggcactggg ctacgtgctg gacagaatca    900

ttgatcagcg attcgagaag gtttcctact ttgtatttgg tgatttcaac ttccggctgg    960

attccaagtc cgtcgtggag acgctctgca caaaagccac catgcagacg gtccgggccg   1020

ccgacaccaa tgaagtggtg aagctcatat ttcgtgagtc ggacaacgac cggaaggtta   1080

tgctccagtt agaaaagaaa ctcttcgact acttcaacca ggaggttttc cgagacaaca   1140

acggcaccgc gctcttggag tttgacaagg agttgtctgt ctttaaggac agactgtatg   1200

aactggacat ctcgttccct cccagctacc cgtacagtga ggacgcccgc cagggtgagc   1260

agtacatgaa cacccggtgc ccagcctggt gtgaccgcat cctcatgtcc ccgtctgcca   1320

aggagctggt gctgcggtcg gagagcgagg agaaggttgt cacctatgac cacattgggc   1380

ccaacgtctg catgggagac cacaagcccg tgttcctggc cttccgaatc atgcccgggg   1440

caggtaaacc tcatgcccat gtgcacaagt gttgtgtcgt gcagtgacgt ggtgggaaga   1500

gatgccagcg ccacgagagg acacttcgtg agcctccctg tagccgtgga ccgaatacgc   1560

actcttgaaa gctgcatcga gaacccgccc aagcgccacc tgctagacgg ccagccccac   1620

acttcgcttc agcctccgga ccattccgga gcagcctcac atacctcact gtctcgtctg   1680

tctatgtgac attaagtaga aatattggtt tttttttttt ttttttaaat aagtcacagt   1740

cctgttgtca aaactctaat agacagcaaa gagggtctgt accgtagact tcacagtttt   1800

cagtttttaa tgattgccag tggaggggct tcttcagcac agagaccccc cactgtgtcc   1860

agggaccccc tctgccaggt ggaggtgtgt ccaggggctg gggaagccga gacgggcact   1920

ccctctgccg gccggcagcg tggccctgag catggcaagg gggtctgtct ctgccgatgc   1980

tccttccgcg gcactgactc tgcgccgtgt cacatggttt ttgaatcaca ctgcagctgc   2040

tttccatttt tatatatata taaatatata taaatatata ctttttaaaa ataatttata   2100

aatcttacca aaacttatgc taaatatact ttccagtatg aacgcacagg agagtcccat   2160

cagcaggcgg cattggagtc taggagctca gctgtgtgtc catcaacaca caaattcgta   2220

aaaaacacac atggcctcgc catcgtgggt aaaatcggcc ccacagcacg tctgcaccag   2280

cgggccgtta ctcccatgcc gttcttctgt gtaatattaa gaactgaatg tgaagtttat   2340

agctagcctg ggtgtacctt ttaagaattt tgtaaaccgt ttgtctgtct tttgttactg   2400

ttttatggtg ccaagtatcc tacgttacaa caataatatc atgggagaaa tagaaatagc   2460

ctagtttgct tccaatagaa actgctttta acatgggctg tatataaaaa tattaaagag   2520

aaacaaaact gtacatttcc tcattgctcc gctacagaca acccatgtca taaccttgtt   2580

gcaaatattt ttctcctata gcagtaagta cagcattaga aggtgattag agagtctgtt   2640

gatgaaacac aaatgtatgt tttattgatt ttactttaga acactacaga gttcctggac   2700

cgggtgaagg cattagctgg gtgtttgtgt gggataaata ctaccactgc aagtgactgc   2760

tgtccgctgc ggaatctgtt cttggtggaa gcacaggtcc gtgtcgctgc tgtggttgcc   2820

gctgtccgcg gttcaacacg gagtccgccc cgcgggtttc agctgttggt cgttctgagg   2880

ggcctttgga agtgaccggt ctggttccta agcaataaaa ttgaccgtgg tgaaaata     2938


<210>  2625
<211>  412
<212>  PRT
<213>  Homosapiens

<400>  2625

Met Ala Gly Lys Ala Ala Ala Pro Gly Thr Ala Val Leu Leu Val Thr 
1               5                   10                  15      


Ala Asn Val Gly Ser Leu Phe Asp Asp Pro Glu Asn Leu Gln Lys Asn 
            20                  25                  30          


Trp Leu Arg Glu Phe Tyr Gln Val Val His Thr His Lys Pro His Phe 
        35                  40                  45              


Met Ala Leu His Cys Gln Glu Phe Gly Gly Lys Asn Tyr Glu Ala Ser 
    50                  55                  60                  


Met Ser His Val Asp Lys Phe Val Lys Glu Leu Leu Ser Ser Asp Ala 
65                  70                  75                  80  


Met Lys Glu Tyr Asn Arg Ala Arg Val Tyr Leu Asp Glu Asn Tyr Lys 
                85                  90                  95      


Ser Gln Glu His Phe Thr Ala Leu Gly Ser Phe Tyr Phe Leu His Glu 
            100                 105                 110         


Ser Leu Lys Asn Ile Tyr Gln Phe Asp Phe Lys Ala Lys Lys Tyr Arg 
        115                 120                 125             


Lys Val Ala Gly Lys Glu Ile Tyr Ser Asp Thr Leu Glu Ser Thr Pro 
    130                 135                 140                 


Met Leu Glu Lys Glu Lys Phe Pro Gln Asp Tyr Phe Pro Glu Cys Lys 
145                 150                 155                 160 


Trp Ser Arg Lys Gly Phe Ile Arg Thr Arg Trp Cys Ile Ala Asp Cys 
                165                 170                 175     


Ala Phe Asp Leu Val Asn Ile His Leu Phe His Asp Ala Ser Asn Leu 
            180                 185                 190         


Val Ala Trp Glu Thr Ser Pro Ser Val Tyr Ser Gly Ile Arg His Lys 
        195                 200                 205             


Ala Leu Gly Tyr Val Leu Asp Arg Ile Ile Asp Gln Arg Phe Glu Lys 
    210                 215                 220                 


Val Ser Tyr Phe Val Phe Gly Asp Phe Asn Phe Arg Leu Asp Ser Lys 
225                 230                 235                 240 


Ser Val Val Glu Thr Leu Cys Thr Lys Ala Thr Met Gln Thr Val Arg 
                245                 250                 255     


Ala Ala Asp Thr Asn Glu Val Val Lys Leu Ile Phe Arg Glu Ser Asp 
            260                 265                 270         


Asn Asp Arg Lys Val Met Leu Gln Leu Glu Lys Lys Leu Phe Asp Tyr 
        275                 280                 285             


Phe Asn Gln Glu Val Phe Arg Asp Asn Asn Gly Thr Ala Leu Leu Glu 
    290                 295                 300                 


Phe Asp Lys Glu Leu Ser Val Phe Lys Asp Arg Leu Tyr Glu Leu Asp 
305                 310                 315                 320 


Ile Ser Phe Pro Pro Ser Tyr Pro Tyr Ser Glu Asp Ala Arg Gln Gly 
                325                 330                 335     


Glu Gln Tyr Met Asn Thr Arg Cys Pro Ala Trp Cys Asp Arg Ile Leu 
            340                 345                 350         


Met Ser Pro Ser Ala Lys Glu Leu Val Leu Arg Ser Glu Ser Glu Glu 
        355                 360                 365             


Lys Val Val Thr Tyr Asp His Ile Gly Pro Asn Val Cys Met Gly Asp 
    370                 375                 380                 


His Lys Pro Val Phe Leu Ala Phe Arg Ile Met Pro Gly Ala Gly Lys 
385                 390                 395                 400 


Pro His Ala His Val His Lys Cys Cys Val Val Gln 
                405                 410         


<210>  2626
<211>  7777
<212>  DNA
<213>  Homosapiens

<400>  2626
agaggggaaa agaacgtcag gagagtgaac gggagcaaat aaaacgctgt ccattctgac     60

tggaagggcc agagccgtgt ctaagggcgg gggccgggag gtggcccgcg gtggtgtctc    120

taccaggacg aggcctgggg tatctgaaga ggggatgacg tccaggcgct ttgctaaagg    180

gaagccagaa gggtatgagt tgctagggtc agagatgggg ctttcggctc gagtctttcc    240

ctgcagggca gagagtccga agagcccgag aaggcaggga ggacagtggg cctggtcctt    300

ccccggccgg cagagggagt cccgagatgg aacgtccagc tctcctctaa cgaaaagcgt    360

ttgcatggct gtctcgccaa ttctgtacct cccggggctg aggaagagcc gaggtgacta    420

gaagctagcg acaagtgccg gccacctccg acgccaggcg ccgggcttgg agcccgacgg    480

gccgaattct cgcgagagcg gccgccgcca tttttccatt gattgcagcg ggctggggga    540

ggggccgacg acgaaggcgg ctgtggtagc ggcggcggcg gcggcggagc cctgggtcgg    600

tgtctgcgcg ctggtgtctg aggcccaggc tgaggcctcc gctattgctg gagcgcaggc    660

ggcggagagg atgactgccg ctgccattct ctcttgagct agcgagccgc cgccaccctc    720

caccctcccc cggcagggcg gagaggagcg gccggagtca gcgatggtgc ccggcgagga    780

gaaccaactg gtcccgaaag aggcaccact ggatcatacc agtgacaagt cacttctcga    840

cgctaatttt gagccaggaa agaagaactt tctgcatttg acagataaag atggtgaaca    900

acctcaaata ctgctggagg attccagtgc tggggaagac agtgttcatg acaggtttat    960

aggtccgctt ccaagagaag gttctggggg ttctaccagt gattatgtca gccaaagcta   1020

ctcctactca tctattttga ataaatcaga aactggatat gtgggactag taaaccaagc   1080

aatgacttgc tatttgaata gccttttgca aacacttttt atgactcctg aatttaggaa   1140

tgcattatat aagtgggaat ttgaagaatc tgaagaagat ccagtgacaa gtattccata   1200

ccaacttcaa aggctttttg ttttgttaca aaccagcaaa aagagagcaa ttgaaaccac   1260

agatgttaca aggagctttg gatgggatag tagtgaggct tggcagcagc atgatgtaca   1320

agaactatgc agagtcatgt ttgatgcttt ggaacagaaa tggaagcaaa cagaacaggc   1380

tgatcttata aatgagctat atcaaggcaa gctgaaggac tacgtgagat gtctggaatg   1440

tggttatgag ggctggcgaa tcgacacata tcttgatatt ccattggtca tccgacctta   1500

tgggtccagc caagcatttg ctagtgtgga agaagcattg catgcattta ttcagccaga   1560

gattctggat ggcccaaatc agtatttttg tgaacgttgt aagaagaagt gtgatgcacg   1620

gaagggcctt cggtttttgc attttcctta tctgctgacc ttacagctga aaagattcga   1680

ttttgattat acaaccatgc ataggattaa actgaatgat cgaatgacat ttcccgagga   1740

actagatatg agtactttta ttgatgttga agatgagaaa tctcctcaga ctgaaagttg   1800

cactgacagt ggagcagaaa atgaaggtag ttgtcacagt gatcagatga gcaacgattt   1860

ctccaatgat gatggtgttg atgaaggaat ctgtcttgaa accaatagtg gaactgaaaa   1920

gatctcaaaa tctggacttg aaaagaattc cttgatctat gaacttttct ctgttatggt   1980

tcattctggg agcgctgctg gtggtcatta ttatgcatgt ataaagtcat tcagtgatga   2040

gcagtggtac agcttcaatg atcaacatgt cagcaggata acacaagagg acattaagaa   2100

aacacatggt ggatcttcag gaagcagagg atattattct agtgctttcg caagttccac   2160

aaatgcatat atgctgatct atagactgaa ggatccagcc agaaatgcaa aatttctaga   2220

agtggatgaa tacccagaac atattaaaaa cttggtgcag aaagagagag agttggaaga   2280

acaagaaaag agacaacgag aaattgagcg caatacatgc aagataaaat tattctgttt   2340

gcatcctaca aaacaagtaa tgatggaaaa taaattggag gttcataagg ataagacatt   2400

aaaggaagca gtagaaatgg cttataagat gatggattta gaagaggtaa tacccctgga   2460

ttgctgtcgc cttgttaaat atgatgagtt tcatgattat ctagaacggt catatgaagg   2520

agaagaagat acaccaatgg ggcttctact aggtggcgtc aagtcaacat atatgtttga   2580

tctgctgttg gagacgagaa agcctgatca ggttttccaa tcttataaac ctggagaagt   2640

gatggtgaaa gttcatgttg ttgatctaaa ggcagaatct gtagctgctc ctataactgt   2700

tcgtgcttac ttaaatcaga cagttacaga attcaaacaa ctgatttcaa aggccatcca   2760

tttacctgct gaaacaatga gaatagtgct ggaacgctgc tacaatgatt tgcgtcttct   2820

cagtgtctcc agtaaaaccc tgaaagctga aggatttttt agaagtaaca aggtgtttgt   2880

tgaaagctcc gagactttgg attaccagat ggcctttgca gactctcatt tatggaaact   2940

cctggatcgg catgcaaata caatcagatt atttgttttg ctacctgaac aatccccagt   3000

atcttattcc aaaaggacag cataccagaa agctggaggc gattctggta atgtggatga   3060

tgactgtgaa agagtcaaag gacctgtagg aagcctaaag tctgtggaag ctattctaga   3120

agaaagcact gaaaaactca aaagcttgtc actgcagcaa cagcaggatg gagataatgg   3180

ggacagcagc aaaagtactg agacaagtga ctttgaaaac atcgaatcac ctctcaatga   3240

gagggactct tcagcatcag tggataatag agaacttgaa cagcatattc agacttctga   3300

tccagaaaat tttcagtctg aagaacgatc agactcagat gtgaataatg acaggagtac   3360

aagttcagtg gacagtgata ttcttagctc cagtcatagc agtgatactt tgtgcaatgc   3420

agacaatgct cagatccctt tggctaatgg acttgactct cacagtatca caagtagtag   3480

aagaacgaaa gcaaatgaag ggaaaaaaga aacatgggat acagcagaag aagactctgg   3540

aactgatagt gaatatgatg agagtggcaa gagtagggga gaaatgcagt acatgtattt   3600

caaagctgaa ccttatgctg cagatgaagg ttctggggaa ggacataaat ggttgatggt   3660

gcatgttgat aaaagaatta ctctggcagc tttcaaacaa catttagagc cctttgttgg   3720

agttttgtcc tctcacttca aggtctttcg agtgtatgcc agcaatcaag agtttgagag   3780

cgtccggctg aatgagacac tttcatcatt ttctgatgac aataagatta caattagact   3840

ggggagagca cttaaaaaag gagaatacag agttaaagta taccagcttt tggtcaatga   3900

acaagagcca tgcaagtttc tgctagatgc tgtgtttgct aaaggaatga ctgtacggca   3960

atcaaaagag gaattaattc ctcagctcag ggagcaatgt ggtttagagc tcagtattga   4020

caggtttcgt ctaaggaaaa aaacatggaa gaatcctggc actgtctttt tggattatca   4080

tatttatgaa gaagatatta atatttccag caactgggag gttttccttg aagttcttga   4140

tggggtagag aagatgaagt ccatgtcaca gcttgcagtt ttgtcaagac ggtggaagcc   4200

ttcagagatg aagttggatc ccttccagga ggttgtattg gaaagcagta gtgtggacga   4260

attgcgagag aagcttagtg aaatcagtgg gattcctttg gatgatattg aatttgctaa   4320

gggtagagga acatttccct gtgatatttc tgtccttgat attcatcagg atttagactg   4380

gaatcctaaa gtttctaccc tgaatgtctg gcctctttat atctgtgatg atggtgcggt   4440

catattttat agggataaaa cagaagaatt aatggaattg acagatgagc aaagaaatga   4500

actgatgaaa aaagaaagca gtcgactcca gaagactgga catcgtgtaa catactcacc   4560

tcgtaaagag aaagcactaa aaatatatct ggatggagca ccaaataaag atctgactca   4620

agactgactc tgatagtgta gcattttccc tgggggagtt ttggttttaa ttagatggtt   4680

cactaccact gggtagtgcc attttggccg gacatggttg gggtaaccca gtgacaccag   4740

cactgattgg actgccctac accaatcaga agctcagtgc ccaatgggcc actgttttga   4800

ctcggaatca tgttgtgcac tatagtcaaa tgtactgtaa agtgaaaagg gatgtgcaaa   4860

aaaataaaaa aaaacaacaa aaaaagctaa ccttctatta gaaaagggga caggggaatg   4920

agtaaacttc ttttattgcg gacaaatgtg cacatagccg ctagtaaaac tagcctcaaa   4980

caggatgctc atagcttaat aataaaagct gtgcaaaggc catgaatgaa tgaattttct   5040

gtttatttca ctgatgcaca cattacctca ttgacaattc agaagtaaat ccaacgtgtg   5100

ttgactcttg gaaagcagca aaaacaggag ctgaagaaaa gaaattcttg gaaccagccg   5160

taacccagta aggaattgtg aagttgtgtt tttattttgt ttcatttttt gcagagtatt   5220

aagaacatta ttctggaaca tcagaacgtt tcccttagac cgatcccagc aggtggcagc   5280

tcagattgct gcagtgttgt aattataact gattgtactt aagttatgga tgtagagaat   5340

atgtttcatt catttattca gcatgtaaat aaaattgatc ctgttgagtt atcataattg   5400

cagttcaact atctgccatg attattcttt tcacgtatca ttcattctgt acatttgtgt   5460

acattgagaa gtatagcaat ctatgtaaat gtaatcctca gtgaggttcc tcagtgctag   5520

gtcccatagg attgtcgttg cccttgttaa tgaggtttct ctgttcagcg gcttcaattt   5580

ttttctcttt gtacatctag ttttgaagat ttacttcaag tttgaatctt ctagaatgct   5640

tgtaagtcca gttttaattt ttagagtcaa tttgtagtta catgtagttt aacttttggg   5700

aaacgtctta acattgttct gaataaactt gctaatgagg tcaggtcatg gtacagactg   5760

atgcagtcaa catgatttca ttgcagagtt tattagtatc agcaagtttt tgctttgcta   5820

aataaaagta ctcaatgaac acaattctac ataaattttg acataccatc taatttataa   5880

aaatcaataa aaaaggtttt ggtaaaactt tttcatgcca gatgctgttt acaacaatga   5940

acatgccaat aaaacatttg ttcattctgt tgtgttattt tagtcattaa acttctgtgg   6000

atgaagaatc tgggttaaga atagatttgt catctttaaa tatgacattt tgtaatgtgt   6060

attggatatc tcatttctat gataaaggta tatttacagt aaagttctca taagagaaat   6120

gaaaagctgt gttaatatct aactttgggg aaccctgtca gtatttcaga tccgattttt   6180

accctttttt tcttataaga aagataaaat tagaaaatac tgttagcaaa tgtggctctg   6240

ccatttgaat ataatcaccg agaattccat gtcttaaaag tctcctggaa tccacaatga   6300

aaaaaaaaat cttttctaag gtatttttct ggctaatttt tatttgaaga aagctatagc   6360

atttagcgaa atttgactga agtaatgttc tgagtttgca ttagtgggat tggtgatgtt   6420

ctcagaagaa aattggaaac acttgtgatg aattgtcttt cagatcactt agattttctg   6480

atgtaagagg acagctgttt ggttctgata caggcctgct tacttgggat gtagggttag   6540

taaatggggt ttctgcttta aaggactgac ttgctatcac acaaaagagg cagacttgta   6600

aacacaatgg gctttggagt ttggtctgat tgggtttggt ttagtattcc tatgagcgta   6660

aatggtaaaa ttcttctgat acccactctt tagactgtgc cttctgctct gttctttgtt   6720

ttatgtttaa ctgctgtttc taattgcagg tgtattacag atacaaataa gagtaaagaa   6780

aatatatttc attatagaaa agaaaaaatt aaaagcttct tgcttttcag tgcctgatag   6840

agtgaaaaca caaagttgca ctttaataat ttcaataaaa gctaatctgt gtcagcctcc   6900

ctctgcttca gagagtcagg tgagcatcca taacctaaca ggcagagccc tagcgatgtg   6960

gatcaagttt cctgagcccg ggggcggtgg agcctcatga tctcttatct tttgaggctg   7020

aggcaggtca catgcaacaa attgtgaccc tgctccccac aagtcatgca aaggttttga   7080

agagctttta ccgtggggca gatgaacttg tgtcaaccat gcacaccctg tgagaaccaa   7140

gtacctgtgt ttctaaggcg ggcactcaag gtgaggggtg cattctggcc aaagaaacaa   7200

aagctgtggt ttcaggacca tgccgtgtgt agctgatctg tacgggacgt gtatgtaagg   7260

aagagcaatc atgatagata agaacagtgt gtgaagcagc cttcacacta gagtgtttgg   7320

tcatctctta taatgtaagg gaaggtactt taaaattctg ggaagatgcg atgaactcat   7380

gtcccagtca gaaaataatc caatgaaata agcattggtt gccaggccac agttaggaat   7440

tgtattgtga tacatctaga ggccaagaga gcaggagaga gctaccaact tacactgtgg   7500

tttaagctaa atgaccgcac agcatcatag cattgcagtg ttgttactaa atctggaagt   7560

gacctgtgaa tgtatggaat acaataaagt cttttattct ggttcatttg ctagtacttc   7620

ctttttgatt ggatactgta gttcttcctc tggattttat tttgttcagc gtcaaggccc   7680

taattttgca aatgtagtct aaaccacatt acgtggacta gaggatactc tgaattagca   7740

agttttttgt ttgctgaata aaactattcc atcttaa                            7777


<210>  2627
<211>  1287
<212>  PRT
<213>  Homosapiens

<400>  2627

Met Val Pro Gly Glu Glu Asn Gln Leu Val Pro Lys Glu Ala Pro Leu 
1               5                   10                  15      


Asp His Thr Ser Asp Lys Ser Leu Leu Asp Ala Asn Phe Glu Pro Gly 
            20                  25                  30          


Lys Lys Asn Phe Leu His Leu Thr Asp Lys Asp Gly Glu Gln Pro Gln 
        35                  40                  45              


Ile Leu Leu Glu Asp Ser Ser Ala Gly Glu Asp Ser Val His Asp Arg 
    50                  55                  60                  


Phe Ile Gly Pro Leu Pro Arg Glu Gly Ser Gly Gly Ser Thr Ser Asp 
65                  70                  75                  80  


Tyr Val Ser Gln Ser Tyr Ser Tyr Ser Ser Ile Leu Asn Lys Ser Glu 
                85                  90                  95      


Thr Gly Tyr Val Gly Leu Val Asn Gln Ala Met Thr Cys Tyr Leu Asn 
            100                 105                 110         


Ser Leu Leu Gln Thr Leu Phe Met Thr Pro Glu Phe Arg Asn Ala Leu 
        115                 120                 125             


Tyr Lys Trp Glu Phe Glu Glu Ser Glu Glu Asp Pro Val Thr Ser Ile 
    130                 135                 140                 


Pro Tyr Gln Leu Gln Arg Leu Phe Val Leu Leu Gln Thr Ser Lys Lys 
145                 150                 155                 160 


Arg Ala Ile Glu Thr Thr Asp Val Thr Arg Ser Phe Gly Trp Asp Ser 
                165                 170                 175     


Ser Glu Ala Trp Gln Gln His Asp Val Gln Glu Leu Cys Arg Val Met 
            180                 185                 190         


Phe Asp Ala Leu Glu Gln Lys Trp Lys Gln Thr Glu Gln Ala Asp Leu 
        195                 200                 205             


Ile Asn Glu Leu Tyr Gln Gly Lys Leu Lys Asp Tyr Val Arg Cys Leu 
    210                 215                 220                 


Glu Cys Gly Tyr Glu Gly Trp Arg Ile Asp Thr Tyr Leu Asp Ile Pro 
225                 230                 235                 240 


Leu Val Ile Arg Pro Tyr Gly Ser Ser Gln Ala Phe Ala Ser Val Glu 
                245                 250                 255     


Glu Ala Leu His Ala Phe Ile Gln Pro Glu Ile Leu Asp Gly Pro Asn 
            260                 265                 270         


Gln Tyr Phe Cys Glu Arg Cys Lys Lys Lys Cys Asp Ala Arg Lys Gly 
        275                 280                 285             


Leu Arg Phe Leu His Phe Pro Tyr Leu Leu Thr Leu Gln Leu Lys Arg 
    290                 295                 300                 


Phe Asp Phe Asp Tyr Thr Thr Met His Arg Ile Lys Leu Asn Asp Arg 
305                 310                 315                 320 


Met Thr Phe Pro Glu Glu Leu Asp Met Ser Thr Phe Ile Asp Val Glu 
                325                 330                 335     


Asp Glu Lys Ser Pro Gln Thr Glu Ser Cys Thr Asp Ser Gly Ala Glu 
            340                 345                 350         


Asn Glu Gly Ser Cys His Ser Asp Gln Met Ser Asn Asp Phe Ser Asn 
        355                 360                 365             


Asp Asp Gly Val Asp Glu Gly Ile Cys Leu Glu Thr Asn Ser Gly Thr 
    370                 375                 380                 


Glu Lys Ile Ser Lys Ser Gly Leu Glu Lys Asn Ser Leu Ile Tyr Glu 
385                 390                 395                 400 


Leu Phe Ser Val Met Val His Ser Gly Ser Ala Ala Gly Gly His Tyr 
                405                 410                 415     


Tyr Ala Cys Ile Lys Ser Phe Ser Asp Glu Gln Trp Tyr Ser Phe Asn 
            420                 425                 430         


Asp Gln His Val Ser Arg Ile Thr Gln Glu Asp Ile Lys Lys Thr His 
        435                 440                 445             


Gly Gly Ser Ser Gly Ser Arg Gly Tyr Tyr Ser Ser Ala Phe Ala Ser 
    450                 455                 460                 


Ser Thr Asn Ala Tyr Met Leu Ile Tyr Arg Leu Lys Asp Pro Ala Arg 
465                 470                 475                 480 


Asn Ala Lys Phe Leu Glu Val Asp Glu Tyr Pro Glu His Ile Lys Asn 
                485                 490                 495     


Leu Val Gln Lys Glu Arg Glu Leu Glu Glu Gln Glu Lys Arg Gln Arg 
            500                 505                 510         


Glu Ile Glu Arg Asn Thr Cys Lys Ile Lys Leu Phe Cys Leu His Pro 
        515                 520                 525             


Thr Lys Gln Val Met Met Glu Asn Lys Leu Glu Val His Lys Asp Lys 
    530                 535                 540                 


Thr Leu Lys Glu Ala Val Glu Met Ala Tyr Lys Met Met Asp Leu Glu 
545                 550                 555                 560 


Glu Val Ile Pro Leu Asp Cys Cys Arg Leu Val Lys Tyr Asp Glu Phe 
                565                 570                 575     


His Asp Tyr Leu Glu Arg Ser Tyr Glu Gly Glu Glu Asp Thr Pro Met 
            580                 585                 590         


Gly Leu Leu Leu Gly Gly Val Lys Ser Thr Tyr Met Phe Asp Leu Leu 
        595                 600                 605             


Leu Glu Thr Arg Lys Pro Asp Gln Val Phe Gln Ser Tyr Lys Pro Gly 
    610                 615                 620                 


Glu Val Met Val Lys Val His Val Val Asp Leu Lys Ala Glu Ser Val 
625                 630                 635                 640 


Ala Ala Pro Ile Thr Val Arg Ala Tyr Leu Asn Gln Thr Val Thr Glu 
                645                 650                 655     


Phe Lys Gln Leu Ile Ser Lys Ala Ile His Leu Pro Ala Glu Thr Met 
            660                 665                 670         


Arg Ile Val Leu Glu Arg Cys Tyr Asn Asp Leu Arg Leu Leu Ser Val 
        675                 680                 685             


Ser Ser Lys Thr Leu Lys Ala Glu Gly Phe Phe Arg Ser Asn Lys Val 
    690                 695                 700                 


Phe Val Glu Ser Ser Glu Thr Leu Asp Tyr Gln Met Ala Phe Ala Asp 
705                 710                 715                 720 


Ser His Leu Trp Lys Leu Leu Asp Arg His Ala Asn Thr Ile Arg Leu 
                725                 730                 735     


Phe Val Leu Leu Pro Glu Gln Ser Pro Val Ser Tyr Ser Lys Arg Thr 
            740                 745                 750         


Ala Tyr Gln Lys Ala Gly Gly Asp Ser Gly Asn Val Asp Asp Asp Cys 
        755                 760                 765             


Glu Arg Val Lys Gly Pro Val Gly Ser Leu Lys Ser Val Glu Ala Ile 
    770                 775                 780                 


Leu Glu Glu Ser Thr Glu Lys Leu Lys Ser Leu Ser Leu Gln Gln Gln 
785                 790                 795                 800 


Gln Asp Gly Asp Asn Gly Asp Ser Ser Lys Ser Thr Glu Thr Ser Asp 
                805                 810                 815     


Phe Glu Asn Ile Glu Ser Pro Leu Asn Glu Arg Asp Ser Ser Ala Ser 
            820                 825                 830         


Val Asp Asn Arg Glu Leu Glu Gln His Ile Gln Thr Ser Asp Pro Glu 
        835                 840                 845             


Asn Phe Gln Ser Glu Glu Arg Ser Asp Ser Asp Val Asn Asn Asp Arg 
    850                 855                 860                 


Ser Thr Ser Ser Val Asp Ser Asp Ile Leu Ser Ser Ser His Ser Ser 
865                 870                 875                 880 


Asp Thr Leu Cys Asn Ala Asp Asn Ala Gln Ile Pro Leu Ala Asn Gly 
                885                 890                 895     


Leu Asp Ser His Ser Ile Thr Ser Ser Arg Arg Thr Lys Ala Asn Glu 
            900                 905                 910         


Gly Lys Lys Glu Thr Trp Asp Thr Ala Glu Glu Asp Ser Gly Thr Asp 
        915                 920                 925             


Ser Glu Tyr Asp Glu Ser Gly Lys Ser Arg Gly Glu Met Gln Tyr Met 
    930                 935                 940                 


Tyr Phe Lys Ala Glu Pro Tyr Ala Ala Asp Glu Gly Ser Gly Glu Gly 
945                 950                 955                 960 


His Lys Trp Leu Met Val His Val Asp Lys Arg Ile Thr Leu Ala Ala 
                965                 970                 975     


Phe Lys Gln His Leu Glu Pro Phe Val Gly Val Leu Ser Ser His Phe 
            980                 985                 990         


Lys Val Phe Arg Val Tyr Ala Ser  Asn Gln Glu Phe Glu  Ser Val Arg 
        995                 1000                 1005             


Leu Asn  Glu Thr Leu Ser Ser  Phe Ser Asp Asp Asn  Lys Ile Thr 
    1010                 1015                 1020             


Ile Arg  Leu Gly Arg Ala Leu  Lys Lys Gly Glu Tyr  Arg Val Lys 
    1025                 1030                 1035             


Val Tyr  Gln Leu Leu Val Asn  Glu Gln Glu Pro Cys  Lys Phe Leu 
    1040                 1045                 1050             


Leu Asp  Ala Val Phe Ala Lys  Gly Met Thr Val Arg  Gln Ser Lys 
    1055                 1060                 1065             


Glu Glu  Leu Ile Pro Gln Leu  Arg Glu Gln Cys Gly  Leu Glu Leu 
    1070                 1075                 1080             


Ser Ile  Asp Arg Phe Arg Leu  Arg Lys Lys Thr Trp  Lys Asn Pro 
    1085                 1090                 1095             


Gly Thr  Val Phe Leu Asp Tyr  His Ile Tyr Glu Glu  Asp Ile Asn 
    1100                 1105                 1110             


Ile Ser  Ser Asn Trp Glu Val  Phe Leu Glu Val Leu  Asp Gly Val 
    1115                 1120                 1125             


Glu Lys  Met Lys Ser Met Ser  Gln Leu Ala Val Leu  Ser Arg Arg 
    1130                 1135                 1140             


Trp Lys  Pro Ser Glu Met Lys  Leu Asp Pro Phe Gln  Glu Val Val 
    1145                 1150                 1155             


Leu Glu  Ser Ser Ser Val Asp  Glu Leu Arg Glu Lys  Leu Ser Glu 
    1160                 1165                 1170             


Ile Ser  Gly Ile Pro Leu Asp  Asp Ile Glu Phe Ala  Lys Gly Arg 
    1175                 1180                 1185             


Gly Thr  Phe Pro Cys Asp Ile  Ser Val Leu Asp Ile  His Gln Asp 
    1190                 1195                 1200             


Leu Asp  Trp Asn Pro Lys Val  Ser Thr Leu Asn Val  Trp Pro Leu 
    1205                 1210                 1215             


Tyr Ile  Cys Asp Asp Gly Ala  Val Ile Phe Tyr Arg  Asp Lys Thr 
    1220                 1225                 1230             


Glu Glu  Leu Met Glu Leu Thr  Asp Glu Gln Arg Asn  Glu Leu Met 
    1235                 1240                 1245             


Lys Lys  Glu Ser Ser Arg Leu  Gln Lys Thr Gly His  Arg Val Thr 
    1250                 1255                 1260             


Tyr Ser  Pro Arg Lys Glu Lys  Ala Leu Lys Ile Tyr  Leu Asp Gly 
    1265                 1270                 1275             


Ala Pro  Asn Lys Asp Leu Thr  Gln Asp 
    1280                 1285         


<210>  2628
<211>  2587
<212>  DNA
<213>  Homosapiens

<400>  2628
cgcgcctctg atcgcgttcc gggacacaca ggcggcggct gcgggcgcag agcggagatg     60

cagcggcttg gggccaccct gctgtgcctg ctgctggcgg cggcggtccc cacggccccc    120

gcgcccgctc cgacggcgac ctcggctcca gtcaagcccg gcccggctct cagctacccg    180

caggaggagg ccaccctcaa tgagatgttc cgcgaggttg aggaactgat ggaggacacg    240

cagcacaaat tgcgcagcgc ggtggaagag atggaggcag aagaagctgc tgctaaagca    300

tcatcagaag tgaacctggc aaacttacct cccagctatc acaatgagac caacacagac    360

acgaaggttg gaaataatac catccatgtg caccgagaaa ttcacaagat aaccaacaac    420

cagactggac aaatggtctt ttcagagaca gttatcacat ctgtgggaga cgaagaaggc    480

agaaggagcc acgagtgcat catcgacgag gactgtgggc ccagcatgta ctgccagttt    540

gccagcttcc agtacacctg ccagccatgc cggggccaga ggatgctctg cacccgggac    600

agtgagtgct gtggagacca gctgtgtgtc tggggtcact gcaccaaaat ggccaccagg    660

ggcagcaatg ggaccatctg tgacaaccag agggactgcc agccggggct gtgctgtgcc    720

ttccagagag gcctgctgtt ccctgtgtgc acacccctgc ccgtggaggg cgagctttgc    780

catgaccccg ccagccggct tctggacctc atcacctggg agctagagcc tgatggagcc    840

ttggaccgat gcccttgtgc cagtggcctc ctctgccagc cccacagcca cagcctggtg    900

tatgtgtgca agccgacctt cgtggggagc cgtgaccaag atggggagat cctgctgccc    960

agagaggtcc ccgatgagta tgaagttggc agcttcatgg aggaggtgcg ccaggagctg   1020

gaggacctgg agaggagcct gactgaagag atggcgctga gggagcctgc ggctgccgcc   1080

gctgcactgc tgggagggga agagatttag atctggacca ggctgtgggt agatgtgcaa   1140

tagaaatagc taatttattt ccccaggtgt gtgctttagg cgtgggctga ccaggcttct   1200

tcctacatct tcttcccagt aagtttcccc tctggcttga cagcatgagg tgttgtgcat   1260

ttgttcagct cccccaggct gttctccagg cttcacagtc tggtgcttgg gagagtcagg   1320

cagggttaaa ctgcaggagc agtttgccac ccctgtccag attattggct gctttgcctc   1380

taccagttgg cagacagccg tttgttctac atggctttga taattgtttg aggggaggag   1440

atggaaacaa tgtggagtct ccctctgatt ggttttgggg aaatgtggag aagagtgccc   1500

tgctttgcaa acatcaacct ggcaaaaatg caacaaatga attttccacg cagttctttc   1560

catgggcata ggtaagctgt gccttcagct gttgcagatg aaatgttctg ttcaccctgc   1620

attacatgtg tttattcatc cagcagtgtt gctcagctcc tacctctgtg ccagggcagc   1680

attttcatat ccaagatcaa ttccctctct cagcacagcc tggggagggg gtcattgttc   1740

tcctcgtcca tcagggatct cagaggctca gagactgcaa gctgcttgcc caagtcacac   1800

agctagtgaa gaccagagca gtttcatctg gttgtgactc taagctcagt gctctctcca   1860

ctaccccaca ccagccttgg tgccaccaaa agtgctcccc aaaaggaagg agaatgggat   1920

ttttcttttg aggcatgcac atctggaatt aaggtcaaac taattctcac atccctctaa   1980

aagtaaacta ctgttaggaa cagcagtgtt ctcacagtgt ggggcagccg tccttctaat   2040

gaagacaatg atattgacac tgtccctctt tggcagttgc attagtaact ttgaaaggta   2100

tatgactgag cgtagcatac aggttaacct gcagaaacag tacttaggta attgtagggc   2160

gaggattata aatgaaattt gcaaaatcac ttagcagcaa ctgaagacaa ttatcaacca   2220

cgtggagaaa atcaaaccga gcagggctgt gtgaaacatg gttgtaatat gcgactgcga   2280

acactgaact ctacgccact ccacaaatga tgttttcagg tgtcatggac tgttgccacc   2340

atgtattcat ccagagttct taaagtttaa agttgcacat gattgtataa gcatgctttc   2400

tttgagtttt aaattatgta taaacataag ttgcatttag aaatcaagca taaatcactt   2460

caactgctct tctgtagttc ttggatttct tttccctttt gactttgaat aaatgtaaaa   2520

tcctttcagc cagaaaaagt aaaatagaaa caacctgtat taaaaatctt ccatagaaaa   2580

aaaaaaa                                                             2587


<210>  2629
<211>  350
<212>  PRT
<213>  Homosapiens

<400>  2629

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe 
        115                 120                 125             


Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 
    130                 135                 140                 


His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 
145                 150                 155                 160 


Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 
                165                 170                 175     


Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 
            180                 185                 190         


Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 
        195                 200                 205             


Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 
    210                 215                 220                 


Gly Leu Leu Phe Pro Val Cys Thr Pro Leu Pro Val Glu Gly Glu Leu 
225                 230                 235                 240 


Cys His Asp Pro Ala Ser Arg Leu Leu Asp Leu Ile Thr Trp Glu Leu 
                245                 250                 255     


Glu Pro Asp Gly Ala Leu Asp Arg Cys Pro Cys Ala Ser Gly Leu Leu 
            260                 265                 270         


Cys Gln Pro His Ser His Ser Leu Val Tyr Val Cys Lys Pro Thr Phe 
        275                 280                 285             


Val Gly Ser Arg Asp Gln Asp Gly Glu Ile Leu Leu Pro Arg Glu Val 
    290                 295                 300                 


Pro Asp Glu Tyr Glu Val Gly Ser Phe Met Glu Glu Val Arg Gln Glu 
305                 310                 315                 320 


Leu Glu Asp Leu Glu Arg Ser Leu Thr Glu Glu Met Ala Leu Arg Glu 
                325                 330                 335     


Pro Ala Ala Ala Ala Ala Ala Leu Leu Gly Gly Glu Glu Ile 
            340                 345                 350 


<210>  2630
<211>  2755
<212>  DNA
<213>  Homosapiens

<400>  2630
ggcggagagg gagcctggtg ggcgggcggg gcgcgtcttg cgggctccct cgggtaccgg     60

cgctgccgca ccccgccgcg ctcccgcacc cgcggcccgc ccaccgcgcc gctcccgcat    120

ctgcacccgc agcccggcgg cctcccggcg ggagcgagca gatccagtcc ggcccgcagc    180

gcaactcggt ccagtcgggg cggcggctgc gggcgcagag cggagatgca gcggcttggg    240

gccaccctgc tgtgcctgct gctggcggcg gcggtcccca cggcccccgc gcccgctccg    300

acggcgacct cggctccagt caagcccggc ccggctctca gctacccgca ggaggaggcc    360

accctcaatg agatgttccg cgaggttgag gaactgatgg aggacacgca gcacaaattg    420

cgcagcgcgg tggaagagat ggaggcagaa gaagctgctg ctaaagcatc atcagaagtg    480

aacctggcaa acttacctcc cagctatcac aatgagacca acacagacac gaaggttgga    540

aataatacca tccatgtgca ccgagaaatt cacaagataa ccaacaacca gactggacaa    600

atggtctttt cagagacagt tatcacatct gtgggagacg aagaaggcag aaggagccac    660

gagtgcatca tcgacgagga ctgtgggccc agcatgtact gccagtttgc cagcttccag    720

tacacctgcc agccatgccg gggccagagg atgctctgca cccgggacag tgagtgctgt    780

ggagaccagc tgtgtgtctg gggtcactgc accaaaatgg ccaccagggg cagcaatggg    840

accatctgtg acaaccagag ggactgccag ccggggctgt gctgtgcctt ccagagaggc    900

ctgctgttcc ctgtgtgcac acccctgccc gtggagggcg agctttgcca tgaccccgcc    960

agccggcttc tggacctcat cacctgggag ctagagcctg atggagcctt ggaccgatgc   1020

ccttgtgcca gtggcctcct ctgccagccc cacagccaca gcctggtgta tgtgtgcaag   1080

ccgaccttcg tggggagccg tgaccaagat ggggagatcc tgctgcccag agaggtcccc   1140

gatgagtatg aagttggcag cttcatggag gaggtgcgcc aggagctgga ggacctggag   1200

aggagcctga ctgaagagat ggcgctgagg gagcctgcgg ctgccgccgc tgcactgctg   1260

ggaggggaag agatttagat ctggaccagg ctgtgggtag atgtgcaata gaaatagcta   1320

atttatttcc ccaggtgtgt gctttaggcg tgggctgacc aggcttcttc ctacatcttc   1380

ttcccagtaa gtttcccctc tggcttgaca gcatgaggtg ttgtgcattt gttcagctcc   1440

cccaggctgt tctccaggct tcacagtctg gtgcttggga gagtcaggca gggttaaact   1500

gcaggagcag tttgccaccc ctgtccagat tattggctgc tttgcctcta ccagttggca   1560

gacagccgtt tgttctacat ggctttgata attgtttgag gggaggagat ggaaacaatg   1620

tggagtctcc ctctgattgg ttttggggaa atgtggagaa gagtgccctg ctttgcaaac   1680

atcaacctgg caaaaatgca acaaatgaat tttccacgca gttctttcca tgggcatagg   1740

taagctgtgc cttcagctgt tgcagatgaa atgttctgtt caccctgcat tacatgtgtt   1800

tattcatcca gcagtgttgc tcagctccta cctctgtgcc agggcagcat tttcatatcc   1860

aagatcaatt ccctctctca gcacagcctg gggagggggt cattgttctc ctcgtccatc   1920

agggatctca gaggctcaga gactgcaagc tgcttgccca agtcacacag ctagtgaaga   1980

ccagagcagt ttcatctggt tgtgactcta agctcagtgc tctctccact accccacacc   2040

agccttggtg ccaccaaaag tgctccccaa aaggaaggag aatgggattt ttcttttgag   2100

gcatgcacat ctggaattaa ggtcaaacta attctcacat ccctctaaaa gtaaactact   2160

gttaggaaca gcagtgttct cacagtgtgg ggcagccgtc cttctaatga agacaatgat   2220

attgacactg tccctctttg gcagttgcat tagtaacttt gaaaggtata tgactgagcg   2280

tagcatacag gttaacctgc agaaacagta cttaggtaat tgtagggcga ggattataaa   2340

tgaaatttgc aaaatcactt agcagcaact gaagacaatt atcaaccacg tggagaaaat   2400

caaaccgagc agggctgtgt gaaacatggt tgtaatatgc gactgcgaac actgaactct   2460

acgccactcc acaaatgatg ttttcaggtg tcatggactg ttgccaccat gtattcatcc   2520

agagttctta aagtttaaag ttgcacatga ttgtataagc atgctttctt tgagttttaa   2580

attatgtata aacataagtt gcatttagaa atcaagcata aatcacttca actgctcttc   2640

tgtagttctt ggatttcttt tcccttttga ctttgaataa atgtaaaatc ctttcagcca   2700

gaaaaagtaa aatagaaaca acctgtatta aaaatcttcc atagaaaaaa aaaaa        2755


<210>  2631
<211>  350
<212>  PRT
<213>  Homosapiens

<400>  2631

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe 
        115                 120                 125             


Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 
    130                 135                 140                 


His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 
145                 150                 155                 160 


Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 
                165                 170                 175     


Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 
            180                 185                 190         


Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 
        195                 200                 205             


Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 
    210                 215                 220                 


Gly Leu Leu Phe Pro Val Cys Thr Pro Leu Pro Val Glu Gly Glu Leu 
225                 230                 235                 240 


Cys His Asp Pro Ala Ser Arg Leu Leu Asp Leu Ile Thr Trp Glu Leu 
                245                 250                 255     


Glu Pro Asp Gly Ala Leu Asp Arg Cys Pro Cys Ala Ser Gly Leu Leu 
            260                 265                 270         


Cys Gln Pro His Ser His Ser Leu Val Tyr Val Cys Lys Pro Thr Phe 
        275                 280                 285             


Val Gly Ser Arg Asp Gln Asp Gly Glu Ile Leu Leu Pro Arg Glu Val 
    290                 295                 300                 


Pro Asp Glu Tyr Glu Val Gly Ser Phe Met Glu Glu Val Arg Gln Glu 
305                 310                 315                 320 


Leu Glu Asp Leu Glu Arg Ser Leu Thr Glu Glu Met Ala Leu Arg Glu 
                325                 330                 335     


Pro Ala Ala Ala Ala Ala Ala Leu Leu Gly Gly Glu Glu Ile 
            340                 345                 350 


<210>  2632
<211>  2769
<212>  DNA
<213>  Homosapiens

<400>  2632
cgacgccaag gggagggggc tgacctgtgc ttggtccacc ccaggtaggg gctgagagag     60

gcttgaggtg gaagtggggg tcgggcactc tgacctggtc gaggaggggc tagggtttga    120

accggggaca gagtctaggt gagctggggc ttgggagcta ttagcgtaga ggatccgggt    180

tcggttgctc tggcgagggc tccagcatca caggcggcgg ctgcgggcgc agagcggaga    240

tgcagcggct tggggccacc ctgctgtgcc tgctgctggc ggcggcggtc cccacggccc    300

ccgcgcccgc tccgacggcg acctcggctc cagtcaagcc cggcccggct ctcagctacc    360

cgcaggagga ggccaccctc aatgagatgt tccgcgaggt tgaggaactg atggaggaca    420

cgcagcacaa attgcgcagc gcggtggaag agatggaggc agaagaagct gctgctaaag    480

catcatcaga agtgaacctg gcaaacttac ctcccagcta tcacaatgag accaacacag    540

acacgaaggt tggaaataat accatccatg tgcaccgaga aattcacaag ataaccaaca    600

accagactgg acaaatggtc ttttcagaga cagttatcac atctgtggga gacgaagaag    660

gcagaaggag ccacgagtgc atcatcgacg aggactgtgg gcccagcatg tactgccagt    720

ttgccagctt ccagtacacc tgccagccat gccggggcca gaggatgctc tgcacccggg    780

acagtgagtg ctgtggagac cagctgtgtg tctggggtca ctgcaccaaa atggccacca    840

ggggcagcaa tgggaccatc tgtgacaacc agagggactg ccagccgggg ctgtgctgtg    900

ccttccagag aggcctgctg ttccctgtgt gcacacccct gcccgtggag ggcgagcttt    960

gccatgaccc cgccagccgg cttctggacc tcatcacctg ggagctagag cctgatggag   1020

ccttggaccg atgcccttgt gccagtggcc tcctctgcca gccccacagc cacagcctgg   1080

tgtatgtgtg caagccgacc ttcgtgggga gccgtgacca agatggggag atcctgctgc   1140

ccagagaggt ccccgatgag tatgaagttg gcagcttcat ggaggaggtg cgccaggagc   1200

tggaggacct ggagaggagc ctgactgaag agatggcgct gagggagcct gcggctgccg   1260

ccgctgcact gctgggaggg gaagagattt agatctggac caggctgtgg gtagatgtgc   1320

aatagaaata gctaatttat ttccccaggt gtgtgcttta ggcgtgggct gaccaggctt   1380

cttcctacat cttcttccca gtaagtttcc cctctggctt gacagcatga ggtgttgtgc   1440

atttgttcag ctcccccagg ctgttctcca ggcttcacag tctggtgctt gggagagtca   1500

ggcagggtta aactgcagga gcagtttgcc acccctgtcc agattattgg ctgctttgcc   1560

tctaccagtt ggcagacagc cgtttgttct acatggcttt gataattgtt tgaggggagg   1620

agatggaaac aatgtggagt ctccctctga ttggttttgg ggaaatgtgg agaagagtgc   1680

cctgctttgc aaacatcaac ctggcaaaaa tgcaacaaat gaattttcca cgcagttctt   1740

tccatgggca taggtaagct gtgccttcag ctgttgcaga tgaaatgttc tgttcaccct   1800

gcattacatg tgtttattca tccagcagtg ttgctcagct cctacctctg tgccagggca   1860

gcattttcat atccaagatc aattccctct ctcagcacag cctggggagg gggtcattgt   1920

tctcctcgtc catcagggat ctcagaggct cagagactgc aagctgcttg cccaagtcac   1980

acagctagtg aagaccagag cagtttcatc tggttgtgac tctaagctca gtgctctctc   2040

cactacccca caccagcctt ggtgccacca aaagtgctcc ccaaaaggaa ggagaatggg   2100

atttttcttt tgaggcatgc acatctggaa ttaaggtcaa actaattctc acatccctct   2160

aaaagtaaac tactgttagg aacagcagtg ttctcacagt gtggggcagc cgtccttcta   2220

atgaagacaa tgatattgac actgtccctc tttggcagtt gcattagtaa ctttgaaagg   2280

tatatgactg agcgtagcat acaggttaac ctgcagaaac agtacttagg taattgtagg   2340

gcgaggatta taaatgaaat ttgcaaaatc acttagcagc aactgaagac aattatcaac   2400

cacgtggaga aaatcaaacc gagcagggct gtgtgaaaca tggttgtaat atgcgactgc   2460

gaacactgaa ctctacgcca ctccacaaat gatgttttca ggtgtcatgg actgttgcca   2520

ccatgtattc atccagagtt cttaaagttt aaagttgcac atgattgtat aagcatgctt   2580

tctttgagtt ttaaattatg tataaacata agttgcattt agaaatcaag cataaatcac   2640

ttcaactgct cttctgtagt tcttggattt cttttccctt ttgactttga ataaatgtaa   2700

aatcctttca gccagaaaaa gtaaaataga aacaacctgt attaaaaatc ttccatagaa   2760

aaaaaaaaa                                                           2769


<210>  2633
<211>  350
<212>  PRT
<213>  Homosapiens

<400>  2633

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe 
        115                 120                 125             


Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 
    130                 135                 140                 


His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 
145                 150                 155                 160 


Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 
                165                 170                 175     


Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 
            180                 185                 190         


Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 
        195                 200                 205             


Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 
    210                 215                 220                 


Gly Leu Leu Phe Pro Val Cys Thr Pro Leu Pro Val Glu Gly Glu Leu 
225                 230                 235                 240 


Cys His Asp Pro Ala Ser Arg Leu Leu Asp Leu Ile Thr Trp Glu Leu 
                245                 250                 255     


Glu Pro Asp Gly Ala Leu Asp Arg Cys Pro Cys Ala Ser Gly Leu Leu 
            260                 265                 270         


Cys Gln Pro His Ser His Ser Leu Val Tyr Val Cys Lys Pro Thr Phe 
        275                 280                 285             


Val Gly Ser Arg Asp Gln Asp Gly Glu Ile Leu Leu Pro Arg Glu Val 
    290                 295                 300                 


Pro Asp Glu Tyr Glu Val Gly Ser Phe Met Glu Glu Val Arg Gln Glu 
305                 310                 315                 320 


Leu Glu Asp Leu Glu Arg Ser Leu Thr Glu Glu Met Ala Leu Arg Glu 
                325                 330                 335     


Pro Ala Ala Ala Ala Ala Ala Leu Leu Gly Gly Glu Glu Ile 
            340                 345                 350 


<210>  2634
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  2634
aggaggaaat ttgcaagagg cggcagcccc tgagcgccca gagctcttga aaggccaccc     60

aggagaggtg tgagacccgg cggcagcatc cgtccaggtg ggacccgctg agcgccgtgg    120

ccagtccccc attcccatcc cggcacccca aaggcgcgct cgcccgattg cttcgagttc    180

cccgacctgg ggattttttt tttagccgct ggtggtgggc gcctcgtggg ctaaggcccg    240

gcgcctgctc tgctacccgc gctgccttta gcggtcgccc ccgccgccgc tgccagggac    300

gtgctgggaa agcccaagcc ccgggagaag atgccggcca tcctggtcgc ctccaaaatg    360

aagtcgggac tgcccaaacc cgtgcacagc gccgcgccca tcctgcacgt gcccccggcc    420

cgggcgggcc cccagccctg ctacctgaag ttgggaagca aggtggaggt gagcaagacc    480

acctatccta gccagatccc cctgaaatcg caggtgctgc aggggctgca ggagccagcg    540

ggggaggggc tcccgctgcg gaagagcggc tcggtggaaa acgggttcga tacccagatc    600

tacacagact gggccaatca ttacctagcc aaatccggcc acaagcgtct catcagggat    660

ctccagcaag atgtgacaga tggcgtcctc ctggcccaga ttatccaggt tgtggcaaat    720

gaaaagattg aagacatcaa tggctgtccg aagaacagat cccaaatgat tgaaaacata    780

gatgcctgct tgaatttcct ggcagctaag ggaataaaca tccaggggct gtctgcagaa    840

gagatcagga atggaaacct caaggccatt ctaggcctct tcttcagcct ctcccgatac    900

aagcagcagc agcagcagcc ccagaagcag cacctctcct cacctctgcc gcccgccgta    960

tcccaggtgg ccggggcccc ctcccagtgc caggctggca cccctcagca gcaggtgcca   1020

gtcactcccc aagccccgtg ccagcctcac cagccagcgc cacatcagca gtcaaaagca   1080

caagctgaaa tgcagtccag acttccaggt cctaccgcga gggtatccgc tgcaggcagc   1140

gaggccaaaa cacgcggagg gtcaactact gctaacaacc gacgcagcca gagctttaac   1200

aactatgata aatccaaacc agtcacctcc ccacccccac cgccaagcag ccacgagaaa   1260

gagcctttgg caagttcagc ctcctcccac cccggaatga gtgacaatgc acctgcttcc   1320

ttggagagcg gcagcagctc cacccctact aattgcagta cctcctcggc catcccgcag   1380

cccggtgcag ccaccaagcc ttggcgcagc aaatccctca gcgtgaagca cagtgccacg   1440

gtatccatgc tctcggtcaa gcctcctggg cctgaggccc ccaggcccac acctgaagcc   1500

atgaagccgg cccccaacaa tcagaagtcc atgctggaaa agctgaaact tttcaacagt   1560

aaagggggct caaaggcagg tgaggggccg gggtcccggg acacaagctg tgagcggctg   1620

gagactctgc ccagcttcga agagagcgag gagctggagg ccgccagtcg catgctcacc   1680

accgtgggcc ctgcttccag cagccccaag attgcactca agggcattgc ccagaggact   1740

tttagccggg cactgaccaa caagaagagt tctctgaaag gcaatgagaa agagaaggag   1800

aaacaacagc gggagaagga taaggagaaa agcaaggacc ttgccaagag agcctctgtg   1860

acggagaggc tggacctcaa ggaggagcca aaagaagacc ccagtggagc agctgtgccc   1920

gagatgccaa aaaagtcctc caagattgcc agcttcatcc ccaaaggggg gaagctcaac   1980

agtgccaaga aggagcccat ggccccttcc cacagtggaa taccaaaacc aggaatgaag   2040

agcatgcccg ggaaatcccc aagtgcccca gcgccttcca aggaagggga gcggagccgg   2100

agtgggaagc tgagctcagg actcccccag cagaagcccc agctggacgg cagacactcc   2160

agttcctctt ccagcctggc gtcctcagaa ggaaaaggcc caggagggac caccctgaac   2220

cacagcatca gcagccagac tgtcagtggg tctgtcggga ccacccagac cacaggaagc   2280

aataccgtca gtgttcagct acctcagccc cagcagcaat acaaccatcc caacactgcc   2340

acggttgcac ctttcctgta caggtctcag acggacactg aagggaatgt tactgccgag   2400

tcaagctcaa caggtgtgag cgtggagccc agccacttca ccaagactgg acagcctgct   2460

ctggaagaac tcactgggga agatcctgag gctcggcggc tgcggacagt gaagaacatc   2520

gctgatctgc ggcagaattt ggaggaaacc atgtccagtt taaggggaac tcaggttaca   2580

cacagcacat tggaaaccac gtttgacacc aatgtcacca cggagatgag tggccgtagc   2640

atactcagct tgacagggag gcccacacct ctgtcctgga gactgggcca gtccagccct   2700

cggctccaag caggagacgc cccctcaatg ggcaatgggt atccccctcg agccaacgcc   2760

agcaggttca tcaacactga gtcaggtcgc tatgtgtact ccgcccctct gagaaggcag   2820

ctggcctccc ggggcagtag tgtctgccat gtggacgtct cagacaaggc aggagatgag   2880

atggacctgg aaggcatcag catggacgcc cccggctaca tgagcgatgg ggatgttctg   2940

agcaagaaca tccggaccga tgacattaca agcggataca tgactgatgg tggacttggc   3000

ctctataccc gtcgcctgaa ccggctccct gatgggatgg ctgtggtacg ggagaccctg   3060

caacgaaata cctccctggg cctcggagac gctgacagct gggacgacag cagctccgtc   3120

agcagcggca tcagcgacac catagacaac ctcagcactg atgacatcaa caccagctcc   3180

tccatcagct cttatgccaa cacacctgcc tcctctcgaa aaaacctgga tgtgcagact   3240

gatgctgaga agcactcaca ggtggagagg aattccctgt ggtctggtga tgatgtcaag   3300

aaatcagacg gaggctcaga cagcggcata aaaatggagc caggttccaa gtggaggcgg   3360

aatccttctg atgtgtctga cgagtccgac aaaagcacgt cgggcaagaa gaatcctgtc   3420

atctcccaga caggctcatg gcggcgaggc atgacagctc aggtgggcat caccatgcca   3480

aggacgaagc cttcagcccc ggcaggcgca ctgaagaccc caggaactgg aaaaacagac   3540

gacgcaaagg tgtctgagaa aggaaggctt tctcctaaag cctcccaggt gaagcgctcc   3600

ccatcagatg caggccggag cagtggtgac gaatccaaaa agcccctccc cagcagctct   3660

aggacaccta ctgccaatgc caacagcttt gggttcaaga agcagagtgg ttccgccgcc   3720

ggcctggcca tgatcacagc cagcggggtg actgtcacca gcaggtcagc cacactgggc   3780

aaaatcccaa agtcatctgc actcgtcagt cggtctgctg gtcggaagtc aagtatggat   3840

ggggctcaga atcaggatga cgggtatcta gccctaagct cccggacaaa ccttcagtac   3900

cggagtttgc cgaggcccag taagtccaac agccggaacg gggctgggaa caggtctagc   3960

accagcagca tagattccaa cattagcagc aagtccgcag gcctgccagt gcccaaactg   4020

agggagcctt ccaaaacagc cctaggcagc tctctaccag gtctggtcaa ccaaacagac   4080

aaggagaaag gcatctcatc agacaacgag agtgtggctt cctgtaactc ggtgaaagtg   4140

aatccggcag cccagcctgt gtccagtccg gctcagacca gtctccagcc tggagccaag   4200

tacccagatg tggcctctcc cacactccgc agactctttg gtgggaagcc taccaagcaa   4260

gtgcccatcg ccacagctga aaacatgaaa aattcggtgg tcatctccaa tcctcatgcc   4320

accatgactc agcaaggtaa cctagactcc ccgtcaggca gtggcgtcct gagcagtggg   4380

agcagcagtc ctctctacag caagaatgtg gacctcaacc agtctccgct agcctccagc   4440

cccagctcag cccactcggc cccttccaac agcctcacct ggggcaccaa cgccagcagc   4500

tcctccgcag ttagcaagga tggcctgggc tttcagtctg tcagcagcct ccacaccagc   4560

tgtgagtcca tcgacatctc cctcagcagt ggaggggtcc ccagccacaa ttcttccact   4620

ggcctcatcg cctcctccaa ggacgactcc ttgactccct ttgtcagaac taacagtgtg   4680

aagaccacac tgtcagaaag ccctctctct tcccctgctg ctagccctaa gttctgcaga   4740

agtactctgc ccaggaaaca ggacagtgac ccgcaccttg ataggaacac tttgcctaag   4800

aaaggactca ggtatactcc cacctcccag cttcgcacgc aagaagatgc aaaagaatgg   4860

ttacggtccc attctgcagg aggccttcag gacaccgctg ccaattcccc cttttcctct   4920

ggctccagcg tgacttctcc ctccggaaca agattcaact tttcccagct tgcgagtccc   4980

accactgtca cccagatgag cttgtccaac ccgaccatgc tgaggactca cagcctctcc   5040

aatgctgatg ggcagtatga tccatacact gacagccgct tccggaatag ctccatgtcc   5100

ctggatgaga agagcagaac catgagccgt tcaggctcat tccgggatgg gtttgaagaa   5160

gttcatggat cctcactctc cttggtttcc agcacatcgt cagtttattc tacaccagaa   5220

gaaaaatgcc agtcagagat tcgcaagctg cggcgggaac tggatgcctc ccaggagaaa   5280

gtttcagctt tgaccaccca gctgacagca aatgctcacc ttgtggcagc ctttgaacag   5340

agtcttggta acatgacaat caggctccag agtctgacca tgacagctga gcagaaggac   5400

tcagaactga atgagttaag aaaaaccatt gagctgctaa agaaacagaa cgcagctgcc   5460

caggctgcca ttaatggagt aattaacaca cctgagctca actgcaaagg aaacggcact   5520

gcccagtctg cagacctccg catccgcagg cagcactcct cagacagcgt ctccagcatc   5580

aacagtgcca ccagccactc cagcgtgggc agcaacatag agagtgactc aaagaagaag   5640

aagcggaaga actggttacg cagctccttc aagcaagctt tcgggaagaa gaagtcccca   5700

aaatctgcgt cctctcattc agatattgag gagatgacgg attcttcttt gccttcctca   5760

ccaaagttac cgcacaatgg gtccacaggt tccaccccac tgctgaggaa ttctcactcc   5820

aactctctaa tttcagaatg catggatagt gaagctgaga ccgtcatgca gctccgaaat   5880

gagttaagag acaaggagat gaagctgacg gatatccgct tagaagctct cagttctgcc   5940

caccagctgg accagctccg ggaggccatg aacaggatgc agagtgaaat agagaagctg   6000

aaagctgaga atgatcggct gaagtcagag tctcaaggca gtggctgcag ccgggctcct   6060

tcccaagtgt ccatctctgc ctccccgagg cagtccatgg gcctctccca gcacagcttg   6120

aacctcactg agtcaaccag cctggacatg ttgctggatg acactggtga atgctcggct   6180

cggaaggaag gaggcaggca tgttaagata gttgtcagct ttcaggagga aatgaagtgg   6240

aaggaggatt ccagaccaca tctctttctt attggctgca ttggagttag tggcaagacg   6300

aagtgggatg tgctcgatgg ggtggttaga cggctgttca aagaatacat cattcatgtc   6360

gacccagtga gtcagctagg gctgaattca gacagcgttc ttggctacag cattggagaa   6420

atcaagcgca gcaacacttc cgaaacaccg gagctgcttc cttgtggcta tctggttgga   6480

gagaacacga ccatctcagt gactgtgaaa gggctcgcag aaaacagcct ggactcactg   6540

gtgtttgagt ccttgattcc caagcccatc ctgcagcgct acgtctccct cctgatagag   6600

caccgtcgga tcattctctc tggccccagc ggcactggga aaacctacct ggccaaccgg   6660

ctgtctgagt atatagtgct tcgagaggga cgggagttga cagacggggt tatcgccacc   6720

tttaacgtgg accataagtc cagcaaggaa ttgcgccagt acctgtccaa ccttgctgac   6780

cagtgcaaca gtgagaacaa tgctgtggac atgcccctcg tcatcatcct ggacaaccta   6840

caccacgtga gctctctggg cgagatcttc aatgggctgc tcaactgcaa gtaccacaaa   6900

tgcccttaca taattggcac aatgaaccag gctacctctt cgactcccaa cctgcagctt   6960

caccataact tcagatgggt gctttgtgcc aaccacacgg agcctgtgaa gggtttcctt   7020

ggccgattcc tgaggaggaa gctcatggaa acagagatca gtgggcgggt gcgcaatatg   7080

gagctggtaa aaatcattga ctggattccc aaggtctggc atcacctcaa ccgcttcctg   7140

gaggctcaca gttcctcgga cgtcaccatc ggcccccggc tcttcctgtc atgccccatc   7200

gatgtggacg gctcgagagt gtggttcacc gacttgtgga actattccat tatcccctat   7260

ctcctggaag ccgtcagaga aggactccag ctctatggaa ggcgcgcccc ctgggaggat   7320

cctgccaagt gggtgatgga cacatatcca tgggcagcca gcccacaaca gcacgagtgg   7380

cctcccctgc tgcagttacg gcctgaggat gtcggcttcg acggctactc catgcctcgg   7440

gagggatcga caagcaagca gatgcccccc agtgatgctg aaggtgaccc gctgatgaac   7500

atgctgatga ggctgcagga ggcagccaac tactccagcc cccagagcta tgacagcgac   7560

tccaacagca acagccatca cgatgacatc ttggactcct ctttggagtc cactctgtga   7620

caggggcccg gagcccagcg ccctcctctt ctcctcaccg cattccacct gcatccccca   7680

catcaccctg aagatgactt cctgagccag cccccagcca cagccttaga gctgcgggaa   7740

caccgagacc ccccgtcctt cagcctcgac ctgggtgcag gcatcccggg ccagctgcct   7800

gcggaccgct tccttccaca gcgagaactg cactaccttc tgttgtactt taattattgt   7860

tttgccttgt tgctgtgacc tccctaagac actgaagata cttctcggga aaggatcatc   7920

gccgttgaaa tgaaaagaga gacagagaga aaaaaaaaaa gagaacccac atgaagctct   7980

gaaaccaaac agcatcctgc catgagcttc ccagagacag aagagactgg agcaaagtcg   8040

gaaacacaga gaagcacggc ttcccctcag cacagaccct ccagactggg tctcagagcc   8100

gtgccaccca ccctcccaca cagccggcca cagggagaac tggtgctaac cagggtgctt   8160

gctttggtca cgttcaacgc actacagagc ta                                 8192


<210>  2635
<211>  2429
<212>  PRT
<213>  Homosapiens

<400>  2635

Met Pro Ala Ile Leu Val Ala Ser Lys Met Lys Ser Gly Leu Pro Lys 
1               5                   10                  15      


Pro Val His Ser Ala Ala Pro Ile Leu His Val Pro Pro Ala Arg Ala 
            20                  25                  30          


Gly Pro Gln Pro Cys Tyr Leu Lys Leu Gly Ser Lys Val Glu Val Ser 
        35                  40                  45              


Lys Thr Thr Tyr Pro Ser Gln Ile Pro Leu Lys Ser Gln Val Leu Gln 
    50                  55                  60                  


Gly Leu Gln Glu Pro Ala Gly Glu Gly Leu Pro Leu Arg Lys Ser Gly 
65                  70                  75                  80  


Ser Val Glu Asn Gly Phe Asp Thr Gln Ile Tyr Thr Asp Trp Ala Asn 
                85                  90                  95      


His Tyr Leu Ala Lys Ser Gly His Lys Arg Leu Ile Arg Asp Leu Gln 
            100                 105                 110         


Gln Asp Val Thr Asp Gly Val Leu Leu Ala Gln Ile Ile Gln Val Val 
        115                 120                 125             


Ala Asn Glu Lys Ile Glu Asp Ile Asn Gly Cys Pro Lys Asn Arg Ser 
    130                 135                 140                 


Gln Met Ile Glu Asn Ile Asp Ala Cys Leu Asn Phe Leu Ala Ala Lys 
145                 150                 155                 160 


Gly Ile Asn Ile Gln Gly Leu Ser Ala Glu Glu Ile Arg Asn Gly Asn 
                165                 170                 175     


Leu Lys Ala Ile Leu Gly Leu Phe Phe Ser Leu Ser Arg Tyr Lys Gln 
            180                 185                 190         


Gln Gln Gln Gln Pro Gln Lys Gln His Leu Ser Ser Pro Leu Pro Pro 
        195                 200                 205             


Ala Val Ser Gln Val Ala Gly Ala Pro Ser Gln Cys Gln Ala Gly Thr 
    210                 215                 220                 


Pro Gln Gln Gln Val Pro Val Thr Pro Gln Ala Pro Cys Gln Pro His 
225                 230                 235                 240 


Gln Pro Ala Pro His Gln Gln Ser Lys Ala Gln Ala Glu Met Gln Ser 
                245                 250                 255     


Arg Leu Pro Gly Pro Thr Ala Arg Val Ser Ala Ala Gly Ser Glu Ala 
            260                 265                 270         


Lys Thr Arg Gly Gly Ser Thr Thr Ala Asn Asn Arg Arg Ser Gln Ser 
        275                 280                 285             


Phe Asn Asn Tyr Asp Lys Ser Lys Pro Val Thr Ser Pro Pro Pro Pro 
    290                 295                 300                 


Pro Ser Ser His Glu Lys Glu Pro Leu Ala Ser Ser Ala Ser Ser His 
305                 310                 315                 320 


Pro Gly Met Ser Asp Asn Ala Pro Ala Ser Leu Glu Ser Gly Ser Ser 
                325                 330                 335     


Ser Thr Pro Thr Asn Cys Ser Thr Ser Ser Ala Ile Pro Gln Pro Gly 
            340                 345                 350         


Ala Ala Thr Lys Pro Trp Arg Ser Lys Ser Leu Ser Val Lys His Ser 
        355                 360                 365             


Ala Thr Val Ser Met Leu Ser Val Lys Pro Pro Gly Pro Glu Ala Pro 
    370                 375                 380                 


Arg Pro Thr Pro Glu Ala Met Lys Pro Ala Pro Asn Asn Gln Lys Ser 
385                 390                 395                 400 


Met Leu Glu Lys Leu Lys Leu Phe Asn Ser Lys Gly Gly Ser Lys Ala 
                405                 410                 415     


Gly Glu Gly Pro Gly Ser Arg Asp Thr Ser Cys Glu Arg Leu Glu Thr 
            420                 425                 430         


Leu Pro Ser Phe Glu Glu Ser Glu Glu Leu Glu Ala Ala Ser Arg Met 
        435                 440                 445             


Leu Thr Thr Val Gly Pro Ala Ser Ser Ser Pro Lys Ile Ala Leu Lys 
    450                 455                 460                 


Gly Ile Ala Gln Arg Thr Phe Ser Arg Ala Leu Thr Asn Lys Lys Ser 
465                 470                 475                 480 


Ser Leu Lys Gly Asn Glu Lys Glu Lys Glu Lys Gln Gln Arg Glu Lys 
                485                 490                 495     


Asp Lys Glu Lys Ser Lys Asp Leu Ala Lys Arg Ala Ser Val Thr Glu 
            500                 505                 510         


Arg Leu Asp Leu Lys Glu Glu Pro Lys Glu Asp Pro Ser Gly Ala Ala 
        515                 520                 525             


Val Pro Glu Met Pro Lys Lys Ser Ser Lys Ile Ala Ser Phe Ile Pro 
    530                 535                 540                 


Lys Gly Gly Lys Leu Asn Ser Ala Lys Lys Glu Pro Met Ala Pro Ser 
545                 550                 555                 560 


His Ser Gly Ile Pro Lys Pro Gly Met Lys Ser Met Pro Gly Lys Ser 
                565                 570                 575     


Pro Ser Ala Pro Ala Pro Ser Lys Glu Gly Glu Arg Ser Arg Ser Gly 
            580                 585                 590         


Lys Leu Ser Ser Gly Leu Pro Gln Gln Lys Pro Gln Leu Asp Gly Arg 
        595                 600                 605             


His Ser Ser Ser Ser Ser Ser Leu Ala Ser Ser Glu Gly Lys Gly Pro 
    610                 615                 620                 


Gly Gly Thr Thr Leu Asn His Ser Ile Ser Ser Gln Thr Val Ser Gly 
625                 630                 635                 640 


Ser Val Gly Thr Thr Gln Thr Thr Gly Ser Asn Thr Val Ser Val Gln 
                645                 650                 655     


Leu Pro Gln Pro Gln Gln Gln Tyr Asn His Pro Asn Thr Ala Thr Val 
            660                 665                 670         


Ala Pro Phe Leu Tyr Arg Ser Gln Thr Asp Thr Glu Gly Asn Val Thr 
        675                 680                 685             


Ala Glu Ser Ser Ser Thr Gly Val Ser Val Glu Pro Ser His Phe Thr 
    690                 695                 700                 


Lys Thr Gly Gln Pro Ala Leu Glu Glu Leu Thr Gly Glu Asp Pro Glu 
705                 710                 715                 720 


Ala Arg Arg Leu Arg Thr Val Lys Asn Ile Ala Asp Leu Arg Gln Asn 
                725                 730                 735     


Leu Glu Glu Thr Met Ser Ser Leu Arg Gly Thr Gln Val Thr His Ser 
            740                 745                 750         


Thr Leu Glu Thr Thr Phe Asp Thr Asn Val Thr Thr Glu Met Ser Gly 
        755                 760                 765             


Arg Ser Ile Leu Ser Leu Thr Gly Arg Pro Thr Pro Leu Ser Trp Arg 
    770                 775                 780                 


Leu Gly Gln Ser Ser Pro Arg Leu Gln Ala Gly Asp Ala Pro Ser Met 
785                 790                 795                 800 


Gly Asn Gly Tyr Pro Pro Arg Ala Asn Ala Ser Arg Phe Ile Asn Thr 
                805                 810                 815     


Glu Ser Gly Arg Tyr Val Tyr Ser Ala Pro Leu Arg Arg Gln Leu Ala 
            820                 825                 830         


Ser Arg Gly Ser Ser Val Cys His Val Asp Val Ser Asp Lys Ala Gly 
        835                 840                 845             


Asp Glu Met Asp Leu Glu Gly Ile Ser Met Asp Ala Pro Gly Tyr Met 
    850                 855                 860                 


Ser Asp Gly Asp Val Leu Ser Lys Asn Ile Arg Thr Asp Asp Ile Thr 
865                 870                 875                 880 


Ser Gly Tyr Met Thr Asp Gly Gly Leu Gly Leu Tyr Thr Arg Arg Leu 
                885                 890                 895     


Asn Arg Leu Pro Asp Gly Met Ala Val Val Arg Glu Thr Leu Gln Arg 
            900                 905                 910         


Asn Thr Ser Leu Gly Leu Gly Asp Ala Asp Ser Trp Asp Asp Ser Ser 
        915                 920                 925             


Ser Val Ser Ser Gly Ile Ser Asp Thr Ile Asp Asn Leu Ser Thr Asp 
    930                 935                 940                 


Asp Ile Asn Thr Ser Ser Ser Ile Ser Ser Tyr Ala Asn Thr Pro Ala 
945                 950                 955                 960 


Ser Ser Arg Lys Asn Leu Asp Val Gln Thr Asp Ala Glu Lys His Ser 
                965                 970                 975     


Gln Val Glu Arg Asn Ser Leu Trp Ser Gly Asp Asp Val Lys Lys Ser 
            980                 985                 990         


Asp Gly Gly Ser Asp Ser Gly Ile  Lys Met Glu Pro Gly  Ser Lys Trp 
        995                 1000                 1005             


Arg Arg  Asn Pro Ser Asp Val  Ser Asp Glu Ser Asp  Lys Ser Thr 
    1010                 1015                 1020             


Ser Gly  Lys Lys Asn Pro Val  Ile Ser Gln Thr Gly  Ser Trp Arg 
    1025                 1030                 1035             


Arg Gly  Met Thr Ala Gln Val  Gly Ile Thr Met Pro  Arg Thr Lys 
    1040                 1045                 1050             


Pro Ser  Ala Pro Ala Gly Ala  Leu Lys Thr Pro Gly  Thr Gly Lys 
    1055                 1060                 1065             


Thr Asp  Asp Ala Lys Val Ser  Glu Lys Gly Arg Leu  Ser Pro Lys 
    1070                 1075                 1080             


Ala Ser  Gln Val Lys Arg Ser  Pro Ser Asp Ala Gly  Arg Ser Ser 
    1085                 1090                 1095             


Gly Asp  Glu Ser Lys Lys Pro  Leu Pro Ser Ser Ser  Arg Thr Pro 
    1100                 1105                 1110             


Thr Ala  Asn Ala Asn Ser Phe  Gly Phe Lys Lys Gln  Ser Gly Ser 
    1115                 1120                 1125             


Ala Ala  Gly Leu Ala Met Ile  Thr Ala Ser Gly Val  Thr Val Thr 
    1130                 1135                 1140             


Ser Arg  Ser Ala Thr Leu Gly  Lys Ile Pro Lys Ser  Ser Ala Leu 
    1145                 1150                 1155             


Val Ser  Arg Ser Ala Gly Arg  Lys Ser Ser Met Asp  Gly Ala Gln 
    1160                 1165                 1170             


Asn Gln  Asp Asp Gly Tyr Leu  Ala Leu Ser Ser Arg  Thr Asn Leu 
    1175                 1180                 1185             


Gln Tyr  Arg Ser Leu Pro Arg  Pro Ser Lys Ser Asn  Ser Arg Asn 
    1190                 1195                 1200             


Gly Ala  Gly Asn Arg Ser Ser  Thr Ser Ser Ile Asp  Ser Asn Ile 
    1205                 1210                 1215             


Ser Ser  Lys Ser Ala Gly Leu  Pro Val Pro Lys Leu  Arg Glu Pro 
    1220                 1225                 1230             


Ser Lys  Thr Ala Leu Gly Ser  Ser Leu Pro Gly Leu  Val Asn Gln 
    1235                 1240                 1245             


Thr Asp  Lys Glu Lys Gly Ile  Ser Ser Asp Asn Glu  Ser Val Ala 
    1250                 1255                 1260             


Ser Cys  Asn Ser Val Lys Val  Asn Pro Ala Ala Gln  Pro Val Ser 
    1265                 1270                 1275             


Ser Pro  Ala Gln Thr Ser Leu  Gln Pro Gly Ala Lys  Tyr Pro Asp 
    1280                 1285                 1290             


Val Ala  Ser Pro Thr Leu Arg  Arg Leu Phe Gly Gly  Lys Pro Thr 
    1295                 1300                 1305             


Lys Gln  Val Pro Ile Ala Thr  Ala Glu Asn Met Lys  Asn Ser Val 
    1310                 1315                 1320             


Val Ile  Ser Asn Pro His Ala  Thr Met Thr Gln Gln  Gly Asn Leu 
    1325                 1330                 1335             


Asp Ser  Pro Ser Gly Ser Gly  Val Leu Ser Ser Gly  Ser Ser Ser 
    1340                 1345                 1350             


Pro Leu  Tyr Ser Lys Asn Val  Asp Leu Asn Gln Ser  Pro Leu Ala 
    1355                 1360                 1365             


Ser Ser  Pro Ser Ser Ala His  Ser Ala Pro Ser Asn  Ser Leu Thr 
    1370                 1375                 1380             


Trp Gly  Thr Asn Ala Ser Ser  Ser Ser Ala Val Ser  Lys Asp Gly 
    1385                 1390                 1395             


Leu Gly  Phe Gln Ser Val Ser  Ser Leu His Thr Ser  Cys Glu Ser 
    1400                 1405                 1410             


Ile Asp  Ile Ser Leu Ser Ser  Gly Gly Val Pro Ser  His Asn Ser 
    1415                 1420                 1425             


Ser Thr  Gly Leu Ile Ala Ser  Ser Lys Asp Asp Ser  Leu Thr Pro 
    1430                 1435                 1440             


Phe Val  Arg Thr Asn Ser Val  Lys Thr Thr Leu Ser  Glu Ser Pro 
    1445                 1450                 1455             


Leu Ser  Ser Pro Ala Ala Ser  Pro Lys Phe Cys Arg  Ser Thr Leu 
    1460                 1465                 1470             


Pro Arg  Lys Gln Asp Ser Asp  Pro His Leu Asp Arg  Asn Thr Leu 
    1475                 1480                 1485             


Pro Lys  Lys Gly Leu Arg Tyr  Thr Pro Thr Ser Gln  Leu Arg Thr 
    1490                 1495                 1500             


Gln Glu  Asp Ala Lys Glu Trp  Leu Arg Ser His Ser  Ala Gly Gly 
    1505                 1510                 1515             


Leu Gln  Asp Thr Ala Ala Asn  Ser Pro Phe Ser Ser  Gly Ser Ser 
    1520                 1525                 1530             


Val Thr  Ser Pro Ser Gly Thr  Arg Phe Asn Phe Ser  Gln Leu Ala 
    1535                 1540                 1545             


Ser Pro  Thr Thr Val Thr Gln  Met Ser Leu Ser Asn  Pro Thr Met 
    1550                 1555                 1560             


Leu Arg  Thr His Ser Leu Ser  Asn Ala Asp Gly Gln  Tyr Asp Pro 
    1565                 1570                 1575             


Tyr Thr  Asp Ser Arg Phe Arg  Asn Ser Ser Met Ser  Leu Asp Glu 
    1580                 1585                 1590             


Lys Ser  Arg Thr Met Ser Arg  Ser Gly Ser Phe Arg  Asp Gly Phe 
    1595                 1600                 1605             


Glu Glu  Val His Gly Ser Ser  Leu Ser Leu Val Ser  Ser Thr Ser 
    1610                 1615                 1620             


Ser Val  Tyr Ser Thr Pro Glu  Glu Lys Cys Gln Ser  Glu Ile Arg 
    1625                 1630                 1635             


Lys Leu  Arg Arg Glu Leu Asp  Ala Ser Gln Glu Lys  Val Ser Ala 
    1640                 1645                 1650             


Leu Thr  Thr Gln Leu Thr Ala  Asn Ala His Leu Val  Ala Ala Phe 
    1655                 1660                 1665             


Glu Gln  Ser Leu Gly Asn Met  Thr Ile Arg Leu Gln  Ser Leu Thr 
    1670                 1675                 1680             


Met Thr  Ala Glu Gln Lys Asp  Ser Glu Leu Asn Glu  Leu Arg Lys 
    1685                 1690                 1695             


Thr Ile  Glu Leu Leu Lys Lys  Gln Asn Ala Ala Ala  Gln Ala Ala 
    1700                 1705                 1710             


Ile Asn  Gly Val Ile Asn Thr  Pro Glu Leu Asn Cys  Lys Gly Asn 
    1715                 1720                 1725             


Gly Thr  Ala Gln Ser Ala Asp  Leu Arg Ile Arg Arg  Gln His Ser 
    1730                 1735                 1740             


Ser Asp  Ser Val Ser Ser Ile  Asn Ser Ala Thr Ser  His Ser Ser 
    1745                 1750                 1755             


Val Gly  Ser Asn Ile Glu Ser  Asp Ser Lys Lys Lys  Lys Arg Lys 
    1760                 1765                 1770             


Asn Trp  Leu Arg Ser Ser Phe  Lys Gln Ala Phe Gly  Lys Lys Lys 
    1775                 1780                 1785             


Ser Pro  Lys Ser Ala Ser Ser  His Ser Asp Ile Glu  Glu Met Thr 
    1790                 1795                 1800             


Asp Ser  Ser Leu Pro Ser Ser  Pro Lys Leu Pro His  Asn Gly Ser 
    1805                 1810                 1815             


Thr Gly  Ser Thr Pro Leu Leu  Arg Asn Ser His Ser  Asn Ser Leu 
    1820                 1825                 1830             


Ile Ser  Glu Cys Met Asp Ser  Glu Ala Glu Thr Val  Met Gln Leu 
    1835                 1840                 1845             


Arg Asn  Glu Leu Arg Asp Lys  Glu Met Lys Leu Thr  Asp Ile Arg 
    1850                 1855                 1860             


Leu Glu  Ala Leu Ser Ser Ala  His Gln Leu Asp Gln  Leu Arg Glu 
    1865                 1870                 1875             


Ala Met  Asn Arg Met Gln Ser  Glu Ile Glu Lys Leu  Lys Ala Glu 
    1880                 1885                 1890             


Asn Asp  Arg Leu Lys Ser Glu  Ser Gln Gly Ser Gly  Cys Ser Arg 
    1895                 1900                 1905             


Ala Pro  Ser Gln Val Ser Ile  Ser Ala Ser Pro Arg  Gln Ser Met 
    1910                 1915                 1920             


Gly Leu  Ser Gln His Ser Leu  Asn Leu Thr Glu Ser  Thr Ser Leu 
    1925                 1930                 1935             


Asp Met  Leu Leu Asp Asp Thr  Gly Glu Cys Ser Ala  Arg Lys Glu 
    1940                 1945                 1950             


Gly Gly  Arg His Val Lys Ile  Val Val Ser Phe Gln  Glu Glu Met 
    1955                 1960                 1965             


Lys Trp  Lys Glu Asp Ser Arg  Pro His Leu Phe Leu  Ile Gly Cys 
    1970                 1975                 1980             


Ile Gly  Val Ser Gly Lys Thr  Lys Trp Asp Val Leu  Asp Gly Val 
    1985                 1990                 1995             


Val Arg  Arg Leu Phe Lys Glu  Tyr Ile Ile His Val  Asp Pro Val 
    2000                 2005                 2010             


Ser Gln  Leu Gly Leu Asn Ser  Asp Ser Val Leu Gly  Tyr Ser Ile 
    2015                 2020                 2025             


Gly Glu  Ile Lys Arg Ser Asn  Thr Ser Glu Thr Pro  Glu Leu Leu 
    2030                 2035                 2040             


Pro Cys  Gly Tyr Leu Val Gly  Glu Asn Thr Thr Ile  Ser Val Thr 
    2045                 2050                 2055             


Val Lys  Gly Leu Ala Glu Asn  Ser Leu Asp Ser Leu  Val Phe Glu 
    2060                 2065                 2070             


Ser Leu  Ile Pro Lys Pro Ile  Leu Gln Arg Tyr Val  Ser Leu Leu 
    2075                 2080                 2085             


Ile Glu  His Arg Arg Ile Ile  Leu Ser Gly Pro Ser  Gly Thr Gly 
    2090                 2095                 2100             


Lys Thr  Tyr Leu Ala Asn Arg  Leu Ser Glu Tyr Ile  Val Leu Arg 
    2105                 2110                 2115             


Glu Gly  Arg Glu Leu Thr Asp  Gly Val Ile Ala Thr  Phe Asn Val 
    2120                 2125                 2130             


Asp His  Lys Ser Ser Lys Glu  Leu Arg Gln Tyr Leu  Ser Asn Leu 
    2135                 2140                 2145             


Ala Asp  Gln Cys Asn Ser Glu  Asn Asn Ala Val Asp  Met Pro Leu 
    2150                 2155                 2160             


Val Ile  Ile Leu Asp Asn Leu  His His Val Ser Ser  Leu Gly Glu 
    2165                 2170                 2175             


Ile Phe  Asn Gly Leu Leu Asn  Cys Lys Tyr His Lys  Cys Pro Tyr 
    2180                 2185                 2190             


Ile Ile  Gly Thr Met Asn Gln  Ala Thr Ser Ser Thr  Pro Asn Leu 
    2195                 2200                 2205             


Gln Leu  His His Asn Phe Arg  Trp Val Leu Cys Ala  Asn His Thr 
    2210                 2215                 2220             


Glu Pro  Val Lys Gly Phe Leu  Gly Arg Phe Leu Arg  Arg Lys Leu 
    2225                 2230                 2235             


Met Glu  Thr Glu Ile Ser Gly  Arg Val Arg Asn Met  Glu Leu Val 
    2240                 2245                 2250             


Lys Ile  Ile Asp Trp Ile Pro  Lys Val Trp His His  Leu Asn Arg 
    2255                 2260                 2265             


Phe Leu  Glu Ala His Ser Ser  Ser Asp Val Thr Ile  Gly Pro Arg 
    2270                 2275                 2280             


Leu Phe  Leu Ser Cys Pro Ile  Asp Val Asp Gly Ser  Arg Val Trp 
    2285                 2290                 2295             


Phe Thr  Asp Leu Trp Asn Tyr  Ser Ile Ile Pro Tyr  Leu Leu Glu 
    2300                 2305                 2310             


Ala Val  Arg Glu Gly Leu Gln  Leu Tyr Gly Arg Arg  Ala Pro Trp 
    2315                 2320                 2325             


Glu Asp  Pro Ala Lys Trp Val  Met Asp Thr Tyr Pro  Trp Ala Ala 
    2330                 2335                 2340             


Ser Pro  Gln Gln His Glu Trp  Pro Pro Leu Leu Gln  Leu Arg Pro 
    2345                 2350                 2355             


Glu Asp  Val Gly Phe Asp Gly  Tyr Ser Met Pro Arg  Glu Gly Ser 
    2360                 2365                 2370             


Thr Ser  Lys Gln Met Pro Pro  Ser Asp Ala Glu Gly  Asp Pro Leu 
    2375                 2380                 2385             


Met Asn  Met Leu Met Arg Leu  Gln Glu Ala Ala Asn  Tyr Ser Ser 
    2390                 2395                 2400             


Pro Gln  Ser Tyr Asp Ser Asp  Ser Asn Ser Asn Ser  His His Asp 
    2405                 2410                 2415             


Asp Ile  Leu Asp Ser Ser Leu  Glu Ser Thr Leu 
    2420                 2425                 


<210>  2636
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  2636
aggaggaaat ttgcaagagg cggcagcccc tgagcgccca gagctcttga aaggccaccc     60

aggagaggtg tgagacccgg cggcagcatc cgtccaggtg ggacccgctg agcgccgtgg    120

ccagtccccc attcccatcc cggcacccca aaggcgcgct cgcccgattg cttcgagttc    180

cccgacctgg ggattttttt tttagccgct ggtggtgggc gcctcgtggg ctaaggcccg    240

gcgcctgctc tgctacccgc gctgccttta gcggtcgccc ccgccgccgc tgccagggac    300

gtgctgggaa agcccaagcc ccgggagaag atgccggcca tcctggtcgc ctccaaaatg    360

aagtcgggac tgcccaaacc cgtgcacagc gccgcgccca tcctgcacgt gcccccggcc    420

cgggcgggcc cccagccctg ctacctgaag ttgggaagca aggtggaggt gagcaagacc    480

acctatccta gccagatccc cctgaaatcg caggtgctgc aggggctgca ggagccagcg    540

ggggaggggc tcccgctgcg gaagagcggc tcggtggaaa acgggttcga tacccagatc    600

tacacagact gggccaatca ttacctagcc aaatccggcc acaagcgtct catcagggat    660

ctccagcaag atgtgacaga tggcgtcctc ctggcccaga ttatccaggt tgtggcaaat    720

gaaaagattg aagacatcaa tggctgtccg aagaacagat cccaaatgat tgaaaacata    780

gatgcctgct tgaatttcct ggcagctaag ggaataaaca tccaggggct gtctgcagaa    840

gagatcagga atggaaacct caaggccatt ctaggcctct tcttcagcct ctcccgatac    900

aagcagcagc agcagcagcc ccagaagcag cacctctcct cacctctgcc gcccgccgta    960

tcccaggtgg ccggggcccc ctcccagtgc caggctggca cccctcagca gcaggtgcca   1020

gtcactcccc aagccccgtg ccagcctcac cagccagcgc cacatcagca gtcaaaagca   1080

caagctgaaa tgcagtccag tgcatcatcc aaggactcat ctcaaagcaa aatcatccgc   1140

ttcactctgg gtcagaaaaa gatctctaga cttccaggtc ctaccgcgag ggtatccgct   1200

gcaggcagcg aggccaaaac acgcggaggg tcaactactg ctaacaaccg acgcagccag   1260

agctttaaca actatgataa atccaaacca gtcacctccc cacccccacc gccaagcagc   1320

cacgagaaag agcctttggc aagttcagcc tcctcccacc ccggaatgag tgacaatgca   1380

cctgcttcct tggagagcgg cagcagctcc acccctacta attgcagtac ctcctcggcc   1440

atcccgcagc ccggtgcagc caccaagcct tggcgcagca aatccctcag cgtgaagcac   1500

agtgccacgg tatccatgct ctcggtcaag cctcctgggc ctgaggcccc caggcccaca   1560

cctgaagcca tgaagccggc ccccaacaat cagaagtcca tgctggaaaa gctgaaactt   1620

ttcaacagta aagggggctc aaaggcaggt gaggggccgg ggtcccggga cacaagctgt   1680

gagcggctgg agactctgcc cagcttcgaa gagagcgagg agctggaggc cgccagtcgc   1740

atgctcacca ccgtgggccc tgcttccagc agccccaaga ttgcactcaa gggcattgcc   1800

cagaggactt ttagccgggc actgaccaac aagaagagtt ctctgaaagg caatgagaaa   1860

gagaaggaga aacaacagcg ggagaaggat aaggagaaaa gcaaggacct tgccaagaga   1920

gcctctgtga cggagaggct ggacctcaag gaggagccaa aagaagaccc cagtggagca   1980

gctgtgcccg agatgccaaa aaagtcctcc aagattgcca gcttcatccc caaagggggg   2040

aagctcaaca gtgccaagaa ggagcccatg gccccttccc acagtggaat accaaaacca   2100

ggaatgaaga gcatgcccgg gaaatcccca agtgccccag cgccttccaa ggaaggggag   2160

cggagccgga gtgggaagct gagctcagga ctcccccagc agaagcccca gctggacggc   2220

agacactcca gttcctcttc cagcctggcg tcctcagaag gaaaaggccc aggagggacc   2280

accctgaacc acagcatcag cagccagact gtcagtgggt ctgtcgggac cacccagacc   2340

acaggaagca ataccgtcag tgttcagcta cctcagcccc agcagcaata caaccatccc   2400

aacactgcca cggttgcacc tttcctgtac aggtctcaga cggacactga agggaatgtt   2460

actgccgagt caagctcaac aggtgtgagc gtggagccca gccacttcac caagactgga   2520

cagcctgctc tggaagaact cactggggaa gatcctgagg ctcggcggct gcggacagtg   2580

aagaacatcg ctgatctgcg gcagaatttg gaggaaacca tgtccagttt aaggggaact   2640

caggttacac acagcacatt ggaaaccacg tttgacacca atgtcaccac ggagatgagt   2700

ggccgtagca tactcagctt gacagggagg cccacacctc tgtcctggag actgggccag   2760

tccagccctc ggctccaagc aggagacgcc ccctcaatgg gcaatgggta tccccctcga   2820

gccaacgcca gcaggttcat caacactgag tcaggtcgct atgtgtactc cgcccctctg   2880

agaaggcagc tggcctcccg gggcagtagt gtctgccatg tggacgtctc agacaaggca   2940

ggagatgaga tggacctgga aggcatcagc atggacgccc ccggctacat gagcgatggg   3000

gatgttctga gcaagaacat ccggaccgat gacattacaa gcggatacat gactgatggt   3060

ggacttggcc tctatacccg tcgcctgaac cggctccctg atgggatggc tgtggtacgg   3120

gagaccctgc aacgaaatac ctccctgggc ctcggagacg ctgacagctg ggacgacagc   3180

agctccgtca gcagcggcat cagcgacacc atagacaacc tcagcactga tgacatcaac   3240

accagctcct ccatcagctc ttatgccaac acacctgcct cctctcgaaa aaacctggat   3300

gtgcagactg atgctgagaa gcactcacag gtggagagga attccctgtg gtctggtgat   3360

gatgtcaaga aatcagacgg aggctcagac agcggcataa aaatggagcc aggttccaag   3420

tggaggcgga atccttctga tgtgtctgac gagtccgaca aaagcacgtc gggcaagaag   3480

aatcctgtca tctcccagac aggctcatgg cggcgaggca tgacagctca ggtgggcatc   3540

accatgccaa ggacgaagcc ttcagccccg gcaggcgcac tgaagacccc aggaactgga   3600

aaaacagacg acgcaaaggt gtctgagaaa ggaaggcttt ctcctaaagc ctcccaggtg   3660

aagcgctccc catcagatgc aggccggagc agtggtgacg aatccaaaaa gcccctcccc   3720

agcagctcta ggacacctac tgccaatgcc aacagctttg ggttcaagaa gcagagtggt   3780

tccgccgccg gcctggccat gatcacagcc agcggggtga ctgtcaccag caggtcagcc   3840

acactgggca aaatcccaaa gtcatctgca ctcgtcagtc ggtctgctgg tcggaagtca   3900

agtatggatg gggctcagaa tcaggatgac gggtatctag ccctaagctc ccggacaaac   3960

cttcagtacc ggagtttgcc gaggcccagt aagtccaaca gccggaacgg ggctgggaac   4020

aggtctagca ccagcagcat agattccaac attagcagca agtccgcagg cctgccagtg   4080

cccaaactga gggagccttc caaaacagcc ctaggcagct ctctaccagg tctggtcaac   4140

caaacagaca aggagaaagg catctcatca gacaacgaga gtgtggcttc ctgtaactcg   4200

gtgaaagtga atccggcagc ccagcctgtg tccagtccgg ctcagaccag tctccagcct   4260

ggagccaagt acccagatgt ggcctctccc acactccgca gactctttgg tgggaagcct   4320

accaagcaag tgcccatcgc cacagctgaa aacatgaaaa attcggtggt catctccaat   4380

cctcatgcca ccatgactca gcaaggtaac ctagactccc cgtcaggcag tggcgtcctg   4440

agcagtggga gcagcagtcc tctctacagc aagaatgtgg acctcaacca gtctccgcta   4500

gcctccagcc ccagctcagc ccactcggcc ccttccaaca gcctcacctg gggcaccaac   4560

gccagcagct cctccgcagt tagcaaggat ggcctgggct ttcagtctgt cagcagcctc   4620

cacaccagct gtgagtccat cgacatctcc ctcagcagtg gaggggtccc cagccacaat   4680

tcttccactg gcctcatcgc ctcctccaag gacgactcct tgactccctt tgtcagaact   4740

aacagtgtga agaccacact gtcagaaagc cctctctctt cccctgctgc tagccctaag   4800

ttctgcagaa gtactctgcc caggaaacag gacagtgacc cgcaccttga taggaacact   4860

ttgcctaaga aaggactcag gtatactccc acctcccagc ttcgcacgca agaagatgca   4920

aaagaatggt tacggtccca ttctgcagga ggccttcagg acaccgctgc caattccccc   4980

ttttcctctg gctccagcgt gacttctccc tccggaacaa gattcaactt ttcccagctt   5040

gcgagtccca ccactgtcac ccagatgagc ttgtccaacc cgaccatgct gaggactcac   5100

agcctctcca atgctgatgg gcagtatgat ccatacactg acagccgctt ccggaatagc   5160

tccatgtccc tggatgagaa gagcagaacc atgagccgtt caggctcatt ccgggatggg   5220

tttgaagaag aatcatggga gaaaagttct gtggacaact ttgtcagccg tcttcacagc   5280

tcacttcatt tctctcttcc tttgttccat cacgcaaggt atgagttagt tcatggatcc   5340

tcactctcct tggtttccag cacatcgtca gtttattcta caccagaaga aaaatgccag   5400

tcagagattc gcaagctgcg gcgggaactg gatgcctccc aggagaaagt ttcagctttg   5460

accacccagc tgacagcaaa tgctcacctt gtggcagcct ttgaacagag tcttggtaac   5520

atgacaatca ggctccagag tctgaccatg acagctgagc agaaggactc agaactgaat   5580

gagttaagaa aaaccattga gctgctaaag aaacagaacg cagctgccca ggctgccatt   5640

aatggagtaa ttaacacacc tgagctcaac tgcaaaggaa acggcactgc ccagtctgca   5700

gacctccgca tccgcaggca gcactcctca gacagcgtct ccagcatcaa cagtgccacc   5760

agccactcca gcgtgggcag caacatagag agtgactcaa agaagaagaa gcggaagaac   5820

tgggtcaatg agttacgcag ctccttcaag caagctttcg ggaagaagaa gtccccaaaa   5880

tctgcgtcct ctcattcaga tattgaggag atgacggatt cttctttgcc ttcctcacca   5940

aagttaccgc acaatgggtc cacaggttcc accccactgc tgaggaattc tcactccaac   6000

tctctaattt cagaatgcat ggatagtgaa gctgagaccg tcatgcagct ccgaaatgag   6060

ttaagagaca aggagatgaa gctgacggat atccgcttag aagctctcag ttctgcccac   6120

cagctggacc agctccggga ggccatgaac aggatgcaga gtgaaataga gaagctgaaa   6180

gctgagaatg atcggctgaa gtcagagtct caaggcagtg gctgcagccg ggctccttcc   6240

caagtgtcca tctctgcctc cccgaggcag tccatgggcc tctcccagca cagcttgaac   6300

ctcactgagt caaccagcct ggacatgttg ctggatgaca ctggtgaatg ctcggctcgg   6360

aaggaaggag gcaggcatgt taagatagtt gtcagctttc aggaggaaat gaagtggaag   6420

gaggattcca gaccacatct ctttcttatt ggctgcattg gagttagtgg caagacgaag   6480

tgggatgtgc tcgatggggt ggttagacgg ctgttcaaag aatacatcat tcatgtcgac   6540

ccagtgagtc agctagggct gaattcagac agcgttcttg gctacagcat tggagaaatc   6600

aagcgcagca acacttccga aacaccggag ctgcttcctt gtggctatct ggttggagag   6660

aacacgacca tctcagtgac tgtgaaaggg ctcgcagaaa acagcctgga ctcactggtg   6720

tttgagtcct tgattcccaa gcccatcctg cagcgctacg tctccctcct gatagagcac   6780

cgtcggatca ttctctctgg ccccagcggc actgggaaaa cctacctggc caaccggctg   6840

tctgagtata tagtgcttcg agagggacgg gagttgacag acggggttat cgccaccttt   6900

aacgtggacc ataagtccag caaggaattg cgccagtacc tgtccaacct tgctgaccag   6960

tgcaacagtg agaacaatgc tgtggacatg cccctcgtca tcatcctgga caacctacac   7020

cacgtgagct ctctgggcga gatcttcaat gggctgctca actgcaagta ccacaaatgc   7080

ccttacataa ttggcacaat gaaccaggct acctcttcga ctcccaacct gcagcttcac   7140

cataacttca gatgggtgct ttgtgccaac cacacggagc ctgtgaaggg tttccttggc   7200

cgattcctga ggaggaagct catggaaaca gagatcagtg ggcgggtgcg caatatggag   7260

ctggtaaaaa tcattgactg gattcccaag gtctggcatc acctcaaccg cttcctggag   7320

gctcacagtt cctcggacgt caccatcggc ccccggctct tcctgtcatg ccccatcgat   7380

gtggacggct cgagagtgtg gttcaccgac ttgtggaact attccattat cccctatctc   7440

ctggaagccg tcagagaagg actccagctc tatggaaggc gcgccccctg ggaggatcct   7500

gccaagtggg tgatggacac atatccatgg gcagccagcc cacaacagca cgagtggcct   7560

cccctgctgc agttacggcc tgaggatgtc ggcttcgacg gctactccat gcctcgggag   7620

ggatcgacaa gcaagcagat gccccccagt gatgctgaag gtgacccgct gatgaacatg   7680

ctgatgaggc tgcaggaggc agccaactac tccagccccc agagctatga cagcgactcc   7740

aacagcaaca gccatcacga tgacatcttg gactcctctt tggagtccac tctgtgacag   7800

gggcccggag cccagcgccc tcctcttctc ctcaccgcat tccacctgca tcccccacat   7860

caccctgaag atgacttcct gagccagccc ccagccacag ccttagagct gcgggaacac   7920

cgagaccccc cgtccttcag cctcgacctg ggtgcaggca tcccgggcca gctgcctgcg   7980

gaccgcttcc ttccacagcg agaactgcac taccttctgt tgtactttaa ttattgtttt   8040

gccttgttgc tgtgacctcc ctaagacact gaagatactt ctcgggaaag gatcatcgcc   8100

gttgaaatga aaagagagac agagagaaaa aaaaaaagag aacccacatg aagctctgaa   8160

accaaacagc atcctgccat gagcttccca ga                                 8192


<210>  2637
<211>  2488
<212>  PRT
<213>  Homosapiens

<400>  2637

Met Pro Ala Ile Leu Val Ala Ser Lys Met Lys Ser Gly Leu Pro Lys 
1               5                   10                  15      


Pro Val His Ser Ala Ala Pro Ile Leu His Val Pro Pro Ala Arg Ala 
            20                  25                  30          


Gly Pro Gln Pro Cys Tyr Leu Lys Leu Gly Ser Lys Val Glu Val Ser 
        35                  40                  45              


Lys Thr Thr Tyr Pro Ser Gln Ile Pro Leu Lys Ser Gln Val Leu Gln 
    50                  55                  60                  


Gly Leu Gln Glu Pro Ala Gly Glu Gly Leu Pro Leu Arg Lys Ser Gly 
65                  70                  75                  80  


Ser Val Glu Asn Gly Phe Asp Thr Gln Ile Tyr Thr Asp Trp Ala Asn 
                85                  90                  95      


His Tyr Leu Ala Lys Ser Gly His Lys Arg Leu Ile Arg Asp Leu Gln 
            100                 105                 110         


Gln Asp Val Thr Asp Gly Val Leu Leu Ala Gln Ile Ile Gln Val Val 
        115                 120                 125             


Ala Asn Glu Lys Ile Glu Asp Ile Asn Gly Cys Pro Lys Asn Arg Ser 
    130                 135                 140                 


Gln Met Ile Glu Asn Ile Asp Ala Cys Leu Asn Phe Leu Ala Ala Lys 
145                 150                 155                 160 


Gly Ile Asn Ile Gln Gly Leu Ser Ala Glu Glu Ile Arg Asn Gly Asn 
                165                 170                 175     


Leu Lys Ala Ile Leu Gly Leu Phe Phe Ser Leu Ser Arg Tyr Lys Gln 
            180                 185                 190         


Gln Gln Gln Gln Pro Gln Lys Gln His Leu Ser Ser Pro Leu Pro Pro 
        195                 200                 205             


Ala Val Ser Gln Val Ala Gly Ala Pro Ser Gln Cys Gln Ala Gly Thr 
    210                 215                 220                 


Pro Gln Gln Gln Val Pro Val Thr Pro Gln Ala Pro Cys Gln Pro His 
225                 230                 235                 240 


Gln Pro Ala Pro His Gln Gln Ser Lys Ala Gln Ala Glu Met Gln Ser 
                245                 250                 255     


Ser Ala Ser Ser Lys Asp Ser Ser Gln Ser Lys Ile Ile Arg Phe Thr 
            260                 265                 270         


Leu Gly Gln Lys Lys Ile Ser Arg Leu Pro Gly Pro Thr Ala Arg Val 
        275                 280                 285             


Ser Ala Ala Gly Ser Glu Ala Lys Thr Arg Gly Gly Ser Thr Thr Ala 
    290                 295                 300                 


Asn Asn Arg Arg Ser Gln Ser Phe Asn Asn Tyr Asp Lys Ser Lys Pro 
305                 310                 315                 320 


Val Thr Ser Pro Pro Pro Pro Pro Ser Ser His Glu Lys Glu Pro Leu 
                325                 330                 335     


Ala Ser Ser Ala Ser Ser His Pro Gly Met Ser Asp Asn Ala Pro Ala 
            340                 345                 350         


Ser Leu Glu Ser Gly Ser Ser Ser Thr Pro Thr Asn Cys Ser Thr Ser 
        355                 360                 365             


Ser Ala Ile Pro Gln Pro Gly Ala Ala Thr Lys Pro Trp Arg Ser Lys 
    370                 375                 380                 


Ser Leu Ser Val Lys His Ser Ala Thr Val Ser Met Leu Ser Val Lys 
385                 390                 395                 400 


Pro Pro Gly Pro Glu Ala Pro Arg Pro Thr Pro Glu Ala Met Lys Pro 
                405                 410                 415     


Ala Pro Asn Asn Gln Lys Ser Met Leu Glu Lys Leu Lys Leu Phe Asn 
            420                 425                 430         


Ser Lys Gly Gly Ser Lys Ala Gly Glu Gly Pro Gly Ser Arg Asp Thr 
        435                 440                 445             


Ser Cys Glu Arg Leu Glu Thr Leu Pro Ser Phe Glu Glu Ser Glu Glu 
    450                 455                 460                 


Leu Glu Ala Ala Ser Arg Met Leu Thr Thr Val Gly Pro Ala Ser Ser 
465                 470                 475                 480 


Ser Pro Lys Ile Ala Leu Lys Gly Ile Ala Gln Arg Thr Phe Ser Arg 
                485                 490                 495     


Ala Leu Thr Asn Lys Lys Ser Ser Leu Lys Gly Asn Glu Lys Glu Lys 
            500                 505                 510         


Glu Lys Gln Gln Arg Glu Lys Asp Lys Glu Lys Ser Lys Asp Leu Ala 
        515                 520                 525             


Lys Arg Ala Ser Val Thr Glu Arg Leu Asp Leu Lys Glu Glu Pro Lys 
    530                 535                 540                 


Glu Asp Pro Ser Gly Ala Ala Val Pro Glu Met Pro Lys Lys Ser Ser 
545                 550                 555                 560 


Lys Ile Ala Ser Phe Ile Pro Lys Gly Gly Lys Leu Asn Ser Ala Lys 
                565                 570                 575     


Lys Glu Pro Met Ala Pro Ser His Ser Gly Ile Pro Lys Pro Gly Met 
            580                 585                 590         


Lys Ser Met Pro Gly Lys Ser Pro Ser Ala Pro Ala Pro Ser Lys Glu 
        595                 600                 605             


Gly Glu Arg Ser Arg Ser Gly Lys Leu Ser Ser Gly Leu Pro Gln Gln 
    610                 615                 620                 


Lys Pro Gln Leu Asp Gly Arg His Ser Ser Ser Ser Ser Ser Leu Ala 
625                 630                 635                 640 


Ser Ser Glu Gly Lys Gly Pro Gly Gly Thr Thr Leu Asn His Ser Ile 
                645                 650                 655     


Ser Ser Gln Thr Val Ser Gly Ser Val Gly Thr Thr Gln Thr Thr Gly 
            660                 665                 670         


Ser Asn Thr Val Ser Val Gln Leu Pro Gln Pro Gln Gln Gln Tyr Asn 
        675                 680                 685             


His Pro Asn Thr Ala Thr Val Ala Pro Phe Leu Tyr Arg Ser Gln Thr 
    690                 695                 700                 


Asp Thr Glu Gly Asn Val Thr Ala Glu Ser Ser Ser Thr Gly Val Ser 
705                 710                 715                 720 


Val Glu Pro Ser His Phe Thr Lys Thr Gly Gln Pro Ala Leu Glu Glu 
                725                 730                 735     


Leu Thr Gly Glu Asp Pro Glu Ala Arg Arg Leu Arg Thr Val Lys Asn 
            740                 745                 750         


Ile Ala Asp Leu Arg Gln Asn Leu Glu Glu Thr Met Ser Ser Leu Arg 
        755                 760                 765             


Gly Thr Gln Val Thr His Ser Thr Leu Glu Thr Thr Phe Asp Thr Asn 
    770                 775                 780                 


Val Thr Thr Glu Met Ser Gly Arg Ser Ile Leu Ser Leu Thr Gly Arg 
785                 790                 795                 800 


Pro Thr Pro Leu Ser Trp Arg Leu Gly Gln Ser Ser Pro Arg Leu Gln 
                805                 810                 815     


Ala Gly Asp Ala Pro Ser Met Gly Asn Gly Tyr Pro Pro Arg Ala Asn 
            820                 825                 830         


Ala Ser Arg Phe Ile Asn Thr Glu Ser Gly Arg Tyr Val Tyr Ser Ala 
        835                 840                 845             


Pro Leu Arg Arg Gln Leu Ala Ser Arg Gly Ser Ser Val Cys His Val 
    850                 855                 860                 


Asp Val Ser Asp Lys Ala Gly Asp Glu Met Asp Leu Glu Gly Ile Ser 
865                 870                 875                 880 


Met Asp Ala Pro Gly Tyr Met Ser Asp Gly Asp Val Leu Ser Lys Asn 
                885                 890                 895     


Ile Arg Thr Asp Asp Ile Thr Ser Gly Tyr Met Thr Asp Gly Gly Leu 
            900                 905                 910         


Gly Leu Tyr Thr Arg Arg Leu Asn Arg Leu Pro Asp Gly Met Ala Val 
        915                 920                 925             


Val Arg Glu Thr Leu Gln Arg Asn Thr Ser Leu Gly Leu Gly Asp Ala 
    930                 935                 940                 


Asp Ser Trp Asp Asp Ser Ser Ser Val Ser Ser Gly Ile Ser Asp Thr 
945                 950                 955                 960 


Ile Asp Asn Leu Ser Thr Asp Asp Ile Asn Thr Ser Ser Ser Ile Ser 
                965                 970                 975     


Ser Tyr Ala Asn Thr Pro Ala Ser Ser Arg Lys Asn Leu Asp Val Gln 
            980                 985                 990         


Thr Asp Ala Glu Lys His Ser Gln  Val Glu Arg Asn Ser  Leu Trp Ser 
        995                 1000                 1005             


Gly Asp  Asp Val Lys Lys Ser  Asp Gly Gly Ser Asp  Ser Gly Ile 
    1010                 1015                 1020             


Lys Met  Glu Pro Gly Ser Lys  Trp Arg Arg Asn Pro  Ser Asp Val 
    1025                 1030                 1035             


Ser Asp  Glu Ser Asp Lys Ser  Thr Ser Gly Lys Lys  Asn Pro Val 
    1040                 1045                 1050             


Ile Ser  Gln Thr Gly Ser Trp  Arg Arg Gly Met Thr  Ala Gln Val 
    1055                 1060                 1065             


Gly Ile  Thr Met Pro Arg Thr  Lys Pro Ser Ala Pro  Ala Gly Ala 
    1070                 1075                 1080             


Leu Lys  Thr Pro Gly Thr Gly  Lys Thr Asp Asp Ala  Lys Val Ser 
    1085                 1090                 1095             


Glu Lys  Gly Arg Leu Ser Pro  Lys Ala Ser Gln Val  Lys Arg Ser 
    1100                 1105                 1110             


Pro Ser  Asp Ala Gly Arg Ser  Ser Gly Asp Glu Ser  Lys Lys Pro 
    1115                 1120                 1125             


Leu Pro  Ser Ser Ser Arg Thr  Pro Thr Ala Asn Ala  Asn Ser Phe 
    1130                 1135                 1140             


Gly Phe  Lys Lys Gln Ser Gly  Ser Ala Ala Gly Leu  Ala Met Ile 
    1145                 1150                 1155             


Thr Ala  Ser Gly Val Thr Val  Thr Ser Arg Ser Ala  Thr Leu Gly 
    1160                 1165                 1170             


Lys Ile  Pro Lys Ser Ser Ala  Leu Val Ser Arg Ser  Ala Gly Arg 
    1175                 1180                 1185             


Lys Ser  Ser Met Asp Gly Ala  Gln Asn Gln Asp Asp  Gly Tyr Leu 
    1190                 1195                 1200             


Ala Leu  Ser Ser Arg Thr Asn  Leu Gln Tyr Arg Ser  Leu Pro Arg 
    1205                 1210                 1215             


Pro Ser  Lys Ser Asn Ser Arg  Asn Gly Ala Gly Asn  Arg Ser Ser 
    1220                 1225                 1230             


Thr Ser  Ser Ile Asp Ser Asn  Ile Ser Ser Lys Ser  Ala Gly Leu 
    1235                 1240                 1245             


Pro Val  Pro Lys Leu Arg Glu  Pro Ser Lys Thr Ala  Leu Gly Ser 
    1250                 1255                 1260             


Ser Leu  Pro Gly Leu Val Asn  Gln Thr Asp Lys Glu  Lys Gly Ile 
    1265                 1270                 1275             


Ser Ser  Asp Asn Glu Ser Val  Ala Ser Cys Asn Ser  Val Lys Val 
    1280                 1285                 1290             


Asn Pro  Ala Ala Gln Pro Val  Ser Ser Pro Ala Gln  Thr Ser Leu 
    1295                 1300                 1305             


Gln Pro  Gly Ala Lys Tyr Pro  Asp Val Ala Ser Pro  Thr Leu Arg 
    1310                 1315                 1320             


Arg Leu  Phe Gly Gly Lys Pro  Thr Lys Gln Val Pro  Ile Ala Thr 
    1325                 1330                 1335             


Ala Glu  Asn Met Lys Asn Ser  Val Val Ile Ser Asn  Pro His Ala 
    1340                 1345                 1350             


Thr Met  Thr Gln Gln Gly Asn  Leu Asp Ser Pro Ser  Gly Ser Gly 
    1355                 1360                 1365             


Val Leu  Ser Ser Gly Ser Ser  Ser Pro Leu Tyr Ser  Lys Asn Val 
    1370                 1375                 1380             


Asp Leu  Asn Gln Ser Pro Leu  Ala Ser Ser Pro Ser  Ser Ala His 
    1385                 1390                 1395             


Ser Ala  Pro Ser Asn Ser Leu  Thr Trp Gly Thr Asn  Ala Ser Ser 
    1400                 1405                 1410             


Ser Ser  Ala Val Ser Lys Asp  Gly Leu Gly Phe Gln  Ser Val Ser 
    1415                 1420                 1425             


Ser Leu  His Thr Ser Cys Glu  Ser Ile Asp Ile Ser  Leu Ser Ser 
    1430                 1435                 1440             


Gly Gly  Val Pro Ser His Asn  Ser Ser Thr Gly Leu  Ile Ala Ser 
    1445                 1450                 1455             


Ser Lys  Asp Asp Ser Leu Thr  Pro Phe Val Arg Thr  Asn Ser Val 
    1460                 1465                 1470             


Lys Thr  Thr Leu Ser Glu Ser  Pro Leu Ser Ser Pro  Ala Ala Ser 
    1475                 1480                 1485             


Pro Lys  Phe Cys Arg Ser Thr  Leu Pro Arg Lys Gln  Asp Ser Asp 
    1490                 1495                 1500             


Pro His  Leu Asp Arg Asn Thr  Leu Pro Lys Lys Gly  Leu Arg Tyr 
    1505                 1510                 1515             


Thr Pro  Thr Ser Gln Leu Arg  Thr Gln Glu Asp Ala  Lys Glu Trp 
    1520                 1525                 1530             


Leu Arg  Ser His Ser Ala Gly  Gly Leu Gln Asp Thr  Ala Ala Asn 
    1535                 1540                 1545             


Ser Pro  Phe Ser Ser Gly Ser  Ser Val Thr Ser Pro  Ser Gly Thr 
    1550                 1555                 1560             


Arg Phe  Asn Phe Ser Gln Leu  Ala Ser Pro Thr Thr  Val Thr Gln 
    1565                 1570                 1575             


Met Ser  Leu Ser Asn Pro Thr  Met Leu Arg Thr His  Ser Leu Ser 
    1580                 1585                 1590             


Asn Ala  Asp Gly Gln Tyr Asp  Pro Tyr Thr Asp Ser  Arg Phe Arg 
    1595                 1600                 1605             


Asn Ser  Ser Met Ser Leu Asp  Glu Lys Ser Arg Thr  Met Ser Arg 
    1610                 1615                 1620             


Ser Gly  Ser Phe Arg Asp Gly  Phe Glu Glu Glu Ser  Trp Glu Lys 
    1625                 1630                 1635             


Ser Ser  Val Asp Asn Phe Val  Ser Arg Leu His Ser  Ser Leu His 
    1640                 1645                 1650             


Phe Ser  Leu Pro Leu Phe His  His Ala Arg Tyr Glu  Leu Val His 
    1655                 1660                 1665             


Gly Ser  Ser Leu Ser Leu Val  Ser Ser Thr Ser Ser  Val Tyr Ser 
    1670                 1675                 1680             


Thr Pro  Glu Glu Lys Cys Gln  Ser Glu Ile Arg Lys  Leu Arg Arg 
    1685                 1690                 1695             


Glu Leu  Asp Ala Ser Gln Glu  Lys Val Ser Ala Leu  Thr Thr Gln 
    1700                 1705                 1710             


Leu Thr  Ala Asn Ala His Leu  Val Ala Ala Phe Glu  Gln Ser Leu 
    1715                 1720                 1725             


Gly Asn  Met Thr Ile Arg Leu  Gln Ser Leu Thr Met  Thr Ala Glu 
    1730                 1735                 1740             


Gln Lys  Asp Ser Glu Leu Asn  Glu Leu Arg Lys Thr  Ile Glu Leu 
    1745                 1750                 1755             


Leu Lys  Lys Gln Asn Ala Ala  Ala Gln Ala Ala Ile  Asn Gly Val 
    1760                 1765                 1770             


Ile Asn  Thr Pro Glu Leu Asn  Cys Lys Gly Asn Gly  Thr Ala Gln 
    1775                 1780                 1785             


Ser Ala  Asp Leu Arg Ile Arg  Arg Gln His Ser Ser  Asp Ser Val 
    1790                 1795                 1800             


Ser Ser  Ile Asn Ser Ala Thr  Ser His Ser Ser Val  Gly Ser Asn 
    1805                 1810                 1815             


Ile Glu  Ser Asp Ser Lys Lys  Lys Lys Arg Lys Asn  Trp Val Asn 
    1820                 1825                 1830             


Glu Leu  Arg Ser Ser Phe Lys  Gln Ala Phe Gly Lys  Lys Lys Ser 
    1835                 1840                 1845             


Pro Lys  Ser Ala Ser Ser His  Ser Asp Ile Glu Glu  Met Thr Asp 
    1850                 1855                 1860             


Ser Ser  Leu Pro Ser Ser Pro  Lys Leu Pro His Asn  Gly Ser Thr 
    1865                 1870                 1875             


Gly Ser  Thr Pro Leu Leu Arg  Asn Ser His Ser Asn  Ser Leu Ile 
    1880                 1885                 1890             


Ser Glu  Cys Met Asp Ser Glu  Ala Glu Thr Val Met  Gln Leu Arg 
    1895                 1900                 1905             


Asn Glu  Leu Arg Asp Lys Glu  Met Lys Leu Thr Asp  Ile Arg Leu 
    1910                 1915                 1920             


Glu Ala  Leu Ser Ser Ala His  Gln Leu Asp Gln Leu  Arg Glu Ala 
    1925                 1930                 1935             


Met Asn  Arg Met Gln Ser Glu  Ile Glu Lys Leu Lys  Ala Glu Asn 
    1940                 1945                 1950             


Asp Arg  Leu Lys Ser Glu Ser  Gln Gly Ser Gly Cys  Ser Arg Ala 
    1955                 1960                 1965             


Pro Ser  Gln Val Ser Ile Ser  Ala Ser Pro Arg Gln  Ser Met Gly 
    1970                 1975                 1980             


Leu Ser  Gln His Ser Leu Asn  Leu Thr Glu Ser Thr  Ser Leu Asp 
    1985                 1990                 1995             


Met Leu  Leu Asp Asp Thr Gly  Glu Cys Ser Ala Arg  Lys Glu Gly 
    2000                 2005                 2010             


Gly Arg  His Val Lys Ile Val  Val Ser Phe Gln Glu  Glu Met Lys 
    2015                 2020                 2025             


Trp Lys  Glu Asp Ser Arg Pro  His Leu Phe Leu Ile  Gly Cys Ile 
    2030                 2035                 2040             


Gly Val  Ser Gly Lys Thr Lys  Trp Asp Val Leu Asp  Gly Val Val 
    2045                 2050                 2055             


Arg Arg  Leu Phe Lys Glu Tyr  Ile Ile His Val Asp  Pro Val Ser 
    2060                 2065                 2070             


Gln Leu  Gly Leu Asn Ser Asp  Ser Val Leu Gly Tyr  Ser Ile Gly 
    2075                 2080                 2085             


Glu Ile  Lys Arg Ser Asn Thr  Ser Glu Thr Pro Glu  Leu Leu Pro 
    2090                 2095                 2100             


Cys Gly  Tyr Leu Val Gly Glu  Asn Thr Thr Ile Ser  Val Thr Val 
    2105                 2110                 2115             


Lys Gly  Leu Ala Glu Asn Ser  Leu Asp Ser Leu Val  Phe Glu Ser 
    2120                 2125                 2130             


Leu Ile  Pro Lys Pro Ile Leu  Gln Arg Tyr Val Ser  Leu Leu Ile 
    2135                 2140                 2145             


Glu His  Arg Arg Ile Ile Leu  Ser Gly Pro Ser Gly  Thr Gly Lys 
    2150                 2155                 2160             


Thr Tyr  Leu Ala Asn Arg Leu  Ser Glu Tyr Ile Val  Leu Arg Glu 
    2165                 2170                 2175             


Gly Arg  Glu Leu Thr Asp Gly  Val Ile Ala Thr Phe  Asn Val Asp 
    2180                 2185                 2190             


His Lys  Ser Ser Lys Glu Leu  Arg Gln Tyr Leu Ser  Asn Leu Ala 
    2195                 2200                 2205             


Asp Gln  Cys Asn Ser Glu Asn  Asn Ala Val Asp Met  Pro Leu Val 
    2210                 2215                 2220             


Ile Ile  Leu Asp Asn Leu His  His Val Ser Ser Leu  Gly Glu Ile 
    2225                 2230                 2235             


Phe Asn  Gly Leu Leu Asn Cys  Lys Tyr His Lys Cys  Pro Tyr Ile 
    2240                 2245                 2250             


Ile Gly  Thr Met Asn Gln Ala  Thr Ser Ser Thr Pro  Asn Leu Gln 
    2255                 2260                 2265             


Leu His  His Asn Phe Arg Trp  Val Leu Cys Ala Asn  His Thr Glu 
    2270                 2275                 2280             


Pro Val  Lys Gly Phe Leu Gly  Arg Phe Leu Arg Arg  Lys Leu Met 
    2285                 2290                 2295             


Glu Thr  Glu Ile Ser Gly Arg  Val Arg Asn Met Glu  Leu Val Lys 
    2300                 2305                 2310             


Ile Ile  Asp Trp Ile Pro Lys  Val Trp His His Leu  Asn Arg Phe 
    2315                 2320                 2325             


Leu Glu  Ala His Ser Ser Ser  Asp Val Thr Ile Gly  Pro Arg Leu 
    2330                 2335                 2340             


Phe Leu  Ser Cys Pro Ile Asp  Val Asp Gly Ser Arg  Val Trp Phe 
    2345                 2350                 2355             


Thr Asp  Leu Trp Asn Tyr Ser  Ile Ile Pro Tyr Leu  Leu Glu Ala 
    2360                 2365                 2370             


Val Arg  Glu Gly Leu Gln Leu  Tyr Gly Arg Arg Ala  Pro Trp Glu 
    2375                 2380                 2385             


Asp Pro  Ala Lys Trp Val Met  Asp Thr Tyr Pro Trp  Ala Ala Ser 
    2390                 2395                 2400             


Pro Gln  Gln His Glu Trp Pro  Pro Leu Leu Gln Leu  Arg Pro Glu 
    2405                 2410                 2415             


Asp Val  Gly Phe Asp Gly Tyr  Ser Met Pro Arg Glu  Gly Ser Thr 
    2420                 2425                 2430             


Ser Lys  Gln Met Pro Pro Ser  Asp Ala Glu Gly Asp  Pro Leu Met 
    2435                 2440                 2445             


Asn Met  Leu Met Arg Leu Gln  Glu Ala Ala Asn Tyr  Ser Ser Pro 
    2450                 2455                 2460             


Gln Ser  Tyr Asp Ser Asp Ser  Asn Ser Asn Ser His  His Asp Asp 
    2465                 2470                 2475             


Ile Leu  Asp Ser Ser Leu Glu  Ser Thr Leu 
    2480                 2485             


<210>  2638
<211>  1149
<212>  DNA
<213>  Homosapiens

<400>  2638
atgatgttcc ccggcctcct cgcgcccccc gccgggtacc ctagcctcct gcggcccacg     60

cccaccttga cgctgcccca gtccttgcag tcggcatttt ccggccactc cagcttcctg    120

gtggaggatc tgatccgcat cagccgaccc cccgcctacc tgccccgcag cgtgcccacc    180

gccagcatgt cgccgcccag gcagggggcc cccacggccc tcaccgacac gggggcctcg    240

gacctgggct ccccgggtcc cggcagccga cggggcggct ctccgccgac tgccttctcc    300

cctgccagcg agacgacgtt tctgaagttt ggagtgaacg ccatcctctc ctcggggccc    360

agaacagaaa catccccagc cttgctccag agcgtccctc ccaagacctt cgcctttccc    420

tacttcgaag ggtcttttca gcctttcatc agatcttctt atttcccagc ttcctccagc    480

gtggtgccca tccccgggac cttctcctgg ccgctggccg cgcgcgggaa gcctcggcgg    540

ggcatgctgc gtcgagcagt cttctccgac gtgcagcgga aggcgctgga gaagatgttc    600

cagaagcaga agtacatcag caagcccgac cgcaagaagc tggcggccaa gctgggcctg    660

aaagactcgc aggacacagc ccgaaggaca gagcctgcac ccgactccac tccccgcccc    720

cgtgcgtccc ccggagcccc tgatctgacc tctgcttctc ccttcttctc gccggccggg    780

acattccagg tgaaaatctg gttccagaac cgacgcatga aatggcggaa ctccaaggag    840

cgcgaactcc tgtctagcgg gggctgtcgc gagcagaccc tgcccaccaa gctcaatccg    900

cacccggacc tcagcgacgt gggccagaag ggccctggga acgaagagga ggaggagggc    960

ccgggcagcc ccagccaccg cctggcctac cacgcgtcct ccgaccccca gcacctgcgg   1020

gacccgcggc tgccagggcc gctgcccccc tcgcccgcgc actcgagcag tcccgggaaa   1080

ccttcggact tctcagattc cgaggaggaa gaggagggcg aggaacagga ggaaatcacc   1140

gtgtcctag                                                           1149


<210>  2639
<211>  382
<212>  PRT
<213>  Homosapiens

<400>  2639

Met Met Phe Pro Gly Leu Leu Ala Pro Pro Ala Gly Tyr Pro Ser Leu 
1               5                   10                  15      


Leu Arg Pro Thr Pro Thr Leu Thr Leu Pro Gln Ser Leu Gln Ser Ala 
            20                  25                  30          


Phe Ser Gly His Ser Ser Phe Leu Val Glu Asp Leu Ile Arg Ile Ser 
        35                  40                  45              


Arg Pro Pro Ala Tyr Leu Pro Arg Ser Val Pro Thr Ala Ser Met Ser 
    50                  55                  60                  


Pro Pro Arg Gln Gly Ala Pro Thr Ala Leu Thr Asp Thr Gly Ala Ser 
65                  70                  75                  80  


Asp Leu Gly Ser Pro Gly Pro Gly Ser Arg Arg Gly Gly Ser Pro Pro 
                85                  90                  95      


Thr Ala Phe Ser Pro Ala Ser Glu Thr Thr Phe Leu Lys Phe Gly Val 
            100                 105                 110         


Asn Ala Ile Leu Ser Ser Gly Pro Arg Thr Glu Thr Ser Pro Ala Leu 
        115                 120                 125             


Leu Gln Ser Val Pro Pro Lys Thr Phe Ala Phe Pro Tyr Phe Glu Gly 
    130                 135                 140                 


Ser Phe Gln Pro Phe Ile Arg Ser Ser Tyr Phe Pro Ala Ser Ser Ser 
145                 150                 155                 160 


Val Val Pro Ile Pro Gly Thr Phe Ser Trp Pro Leu Ala Ala Arg Gly 
                165                 170                 175     


Lys Pro Arg Arg Gly Met Leu Arg Arg Ala Val Phe Ser Asp Val Gln 
            180                 185                 190         


Arg Lys Ala Leu Glu Lys Met Phe Gln Lys Gln Lys Tyr Ile Ser Lys 
        195                 200                 205             


Pro Asp Arg Lys Lys Leu Ala Ala Lys Leu Gly Leu Lys Asp Ser Gln 
    210                 215                 220                 


Asp Thr Ala Arg Arg Thr Glu Pro Ala Pro Asp Ser Thr Pro Arg Pro 
225                 230                 235                 240 


Arg Ala Ser Pro Gly Ala Pro Asp Leu Thr Ser Ala Ser Pro Phe Phe 
                245                 250                 255     


Ser Pro Ala Gly Thr Phe Gln Val Lys Ile Trp Phe Gln Asn Arg Arg 
            260                 265                 270         


Met Lys Trp Arg Asn Ser Lys Glu Arg Glu Leu Leu Ser Ser Gly Gly 
        275                 280                 285             


Cys Arg Glu Gln Thr Leu Pro Thr Lys Leu Asn Pro His Pro Asp Leu 
    290                 295                 300                 


Ser Asp Val Gly Gln Lys Gly Pro Gly Asn Glu Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Pro Gly Ser Pro Ser His Arg Leu Ala Tyr His Ala Ser Ser Asp Pro 
                325                 330                 335     


Gln His Leu Arg Asp Pro Arg Leu Pro Gly Pro Leu Pro Pro Ser Pro 
            340                 345                 350         


Ala His Ser Ser Ser Pro Gly Lys Pro Ser Asp Phe Ser Asp Ser Glu 
        355                 360                 365             


Glu Glu Glu Glu Gly Glu Glu Gln Glu Glu Ile Thr Val Ser 
    370                 375                 380         


<210>  2640
<211>  1438
<212>  DNA
<213>  Homosapiens

<400>  2640
ggatgctctg atggccgggc ctgcggcgct gagcgcggcg gcggcggctg ctctggcggc     60

cgccctgctc ctgctgcgtc gtgaggaccc ggggccgggg gctggcccca gcatggccga    120

aacagaagcc ctgtcgaagc ttcgggaaga cttcaggatg cagaataaat ccgtctttat    180

tttgggcgcc agcggagaaa ccggcagagt gctcttaaag gaaatcctgg agcagggcct    240

gttttccaaa gtcacgctca ttggccggag gaagctcacc ttcgacgagg aagcttataa    300

aaatgtgaat caagaagtgg tggactttga aaagttggat gactacgcct ctgcctttca    360

aggtcatgat gttggattct gttgcctggg taccaccaga gggaaagctg gggcggaggg    420

atttgttcgt gttgaccgag attatgtgct gaagtctgca gagctggcaa aagctggagg    480

gtgcaaacat ttcaacttgc tatcctctaa aggagctgat aaatcaagca attttttata    540

tctacaagtt aagggagaag tagaagccaa ggttgaagaa ttaaaatttg atcgttactc    600

tgtatttagg cctggagttc tgttatgtga taggcaagaa tctcgcccag gtgaatggct    660

ggttagaaag ttctttggct ccttaccaga ctcttgggcc agggggcatt ctgtgcctgt    720

ggtgaccgtg gttagagcaa tgctgaacaa tgtggtgaga ccaagagaca agcagatgga    780

actgctggag aacaaggcca tccatgacct ggggaaagcg catggctctc tcaagccatg    840

accacactgg agaaatggtt tttattgtca accttaacac ccatcaccaa atcggtaatt    900

tcagggtcta aaaaaagtca gcatgtttta actttgttgt tttactatcc tcaggcatcc    960

attccaatca agaaatgatg gtgctctgca tcagtggttc agagcctggt tatacatata   1020

gatcactcag ggagctttgg aaaaataaag atttgtcagc cctatctcaa acttgaatca   1080

aaatttctgg ggtgtgggca caataatctg taattttctt tgtttatact tcccctgatg   1140

ccactggttc cgatgccact ggctgggggg cctgctttga aatgcttgtc tgcagagtca   1200

cagcagccat gaaaacctta tgaccgtgca aatgagctct gctctaaaat tgttgacatt   1260

catgtctctg agttacaaaa gtgctaattc actacatgta attgtgtaag taaacattgt   1320

gcctttacta cttctttatg taatagaagt tatataccta agcttatata atacatgggg   1380

aggattaaat aaaggaataa agatgaatgg acaactccaa aaaaaaaaaa aaaaaaaa     1438


<210>  2641
<211>  242
<212>  PRT
<213>  Homosapiens

<400>  2641

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Glu Gly Phe Val Arg Val Asp Arg Asp Tyr Val 
            100                 105                 110         


Leu Lys Ser Ala Glu Leu Ala Lys Ala Gly Gly Cys Lys His Phe Asn 
        115                 120                 125             


Leu Leu Ser Ser Lys Gly Ala Asp Lys Ser Ser Asn Phe Leu Tyr Leu 
    130                 135                 140                 


Gln Val Lys Gly Glu Val Glu Ala Lys Val Glu Glu Leu Lys Phe Asp 
145                 150                 155                 160 


Arg Tyr Ser Val Phe Arg Pro Gly Val Leu Leu Cys Asp Arg Gln Glu 
                165                 170                 175     


Ser Arg Pro Gly Glu Trp Leu Val Arg Lys Phe Phe Gly Ser Leu Pro 
            180                 185                 190         


Asp Ser Trp Ala Arg Gly His Ser Val Pro Val Val Thr Val Val Arg 
        195                 200                 205             


Ala Met Leu Asn Asn Val Val Arg Pro Arg Asp Lys Gln Met Glu Leu 
    210                 215                 220                 


Leu Glu Asn Lys Ala Ile His Asp Leu Gly Lys Ala His Gly Ser Leu 
225                 230                 235                 240 


Lys Pro 
        


<210>  2642
<211>  2632
<212>  DNA
<213>  Homosapiens

<400>  2642
ggggaagcga ttgcgagcca gcgcgcgcgc ttcggcgttc ccggcggtct gcgaagtttc     60

cggagccccg gtcccgccgc gggttcgcgc ttgtgctcgc gctcgttcct ggagtcggcg    120

gccgctgcgc gcgctcgttg cccaacccgg tccccgcccc cagacacgcc gggctctcgg    180

ggcaccacag ccatgtgctc gttagcgtca ggcgctaccg gcggccgggg cgctgtggag    240

aatgaggagg acctgccaga actgtcggac agcggggacg aggccgcctg ggaggatgag    300

gacgatgcag atctccccca cggcaagcag cagaccccct gcctgttctg taacaggtta    360

ttcacatctg ctgaagaaac attttcacac tgtaagtctg agcatcagtt taatattgac    420

agcatggttc ataaacatgg acttgaattt tatggataca ttaagctaat aaattttatt    480

agacttaaga atcctacagt tgagtacatg aattccatat acaacccagt gccttgggag    540

aaagaagagt atttgaagcc agtattagaa gatgaccttt tacttcaatt tgatgtagaa    600

gatctttatg aaccggtgtc agtacccttc tcatacccca atggactcag tgaaaataca    660

tctgttgttg aaaaattgaa acatatggaa gccagggcac tgtctgctga agccgcattg    720

gccagagcac gtgaggatct gcaaaaaatg aaacaatttg ctcaggattt tgtgatgcac    780

acagatgtca gaacctgctc gtcatctact agtgtcattg cggacctcca ggaggatgag    840

gatggtgttt atttcagctc atacgggcat tatgggatac atgaagaaat gctaaaggac    900

aaaatacgaa cagaaagcta ccgagatttc atataccaaa atccacatat cttcaaagac    960

aaggtagttt tggatgttgg gtgtggaact ggaattctct ctatgtttgc tgctaaagct   1020

ggggcgaaga aggttcttgg agttgatcaa tctgaaatac tttaccaggc aatggatatt   1080

ataagactaa ataaacttga agatactatt acactaatta aaggaaagat tgaagaagtt   1140

catcttcctg tagaaaaagt agatgttatc atatctgagt ggatgggcta ttttcttctg   1200

tttgagtcta tgttagattc tgtcctttat gcaaagaaca aatacttggc aaaaggaggc   1260

tcggtctacc ctgacatttg cactatcagc cttgtagcag tgagtgatgt gaataaacat   1320

gctgatagaa ttgctttttg ggatgatgtc tatggcttca agatgtcctg catgaagaaa   1380

gcagttattc cagaagctgt tgtggaagtt ttagatccga agactcttat ttcagaacct   1440

tgtggtatta agcatataga ttgccatacg acgtctatct cagatttgga attttcatca   1500

gattttaccc tgaaaatcac aaggacatcc atgtgcacgg caattgctgg ctactttgat   1560

atatattttg agaagaattg ccacaacagg gtcgtgttct ctacgggccc tcagagcacc   1620

aaaacacact ggaaacaaac agtatttcta ctggaaaaac cattttcagt taaagcaggt   1680

gaagccttga aaggaaaggt cacagttcac aagaataaga aagatccacg ttctctcacc   1740

gtgaccctca cgttgaataa ttcaactcaa acttatggtc tccagtgaaa cagccataaa   1800

agcacactac cttgtagttt ttaatgtggg ggtagagtgg gtcagcagga gggagctggt   1860

tttatgtgag cagatggatg gatgatggac cctttcctaa tgagcctcct caataagaga   1920

gaagttctca ttgtgggaat ctgacatagt tcagctgagg aagagaatca gctgatcctc   1980

atggtctgcc acgtaatcat tttcttagac gtttgctcca ccagatttaa ccaaatgtaa   2040

ctcccacatt gagtttatct atattgaaaa tcatttacat tggcctatat ttggaagaga   2100

gatagtcttt tgtttttaat aagtttctta ctataaattt taaacaaatt ggttagttat   2160

ttggatattt tattaaacta gtaacacagg tactacacat tttattatgg actcctctga   2220

ggaggagttt ttaattgtat ttgctagaaa atcaggatgt aataaagatt tgtataaaaa   2280

aactaaaata tggaaaagag cttcagcctt catatacaaa tcatatatgc agacagccta   2340

gttgattatc tagcatactt agggttctca ttttgtagtt tcttccctct ttgtgactat   2400

tccttagcct tatagatttc tagtactgcc caggaaatct aatttcaata catttatcct   2460

aggtttcatg aaagttttta aagattggga taaatatgta cttatttact aacgtattat   2520

ctttttcaaa ccagatttat gtgcaaaggt taaacatgta actgttacta agcagtctat   2580

aaagttgtca tttacaatta ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa           2632


<210>  2643
<211>  531
<212>  PRT
<213>  Homosapiens

<400>  2643

Met Cys Ser Leu Ala Ser Gly Ala Thr Gly Gly Arg Gly Ala Val Glu 
1               5                   10                  15      


Asn Glu Glu Asp Leu Pro Glu Leu Ser Asp Ser Gly Asp Glu Ala Ala 
            20                  25                  30          


Trp Glu Asp Glu Asp Asp Ala Asp Leu Pro His Gly Lys Gln Gln Thr 
        35                  40                  45              


Pro Cys Leu Phe Cys Asn Arg Leu Phe Thr Ser Ala Glu Glu Thr Phe 
    50                  55                  60                  


Ser His Cys Lys Ser Glu His Gln Phe Asn Ile Asp Ser Met Val His 
65                  70                  75                  80  


Lys His Gly Leu Glu Phe Tyr Gly Tyr Ile Lys Leu Ile Asn Phe Ile 
                85                  90                  95      


Arg Leu Lys Asn Pro Thr Val Glu Tyr Met Asn Ser Ile Tyr Asn Pro 
            100                 105                 110         


Val Pro Trp Glu Lys Glu Glu Tyr Leu Lys Pro Val Leu Glu Asp Asp 
        115                 120                 125             


Leu Leu Leu Gln Phe Asp Val Glu Asp Leu Tyr Glu Pro Val Ser Val 
    130                 135                 140                 


Pro Phe Ser Tyr Pro Asn Gly Leu Ser Glu Asn Thr Ser Val Val Glu 
145                 150                 155                 160 


Lys Leu Lys His Met Glu Ala Arg Ala Leu Ser Ala Glu Ala Ala Leu 
                165                 170                 175     


Ala Arg Ala Arg Glu Asp Leu Gln Lys Met Lys Gln Phe Ala Gln Asp 
            180                 185                 190         


Phe Val Met His Thr Asp Val Arg Thr Cys Ser Ser Ser Thr Ser Val 
        195                 200                 205             


Ile Ala Asp Leu Gln Glu Asp Glu Asp Gly Val Tyr Phe Ser Ser Tyr 
    210                 215                 220                 


Gly His Tyr Gly Ile His Glu Glu Met Leu Lys Asp Lys Ile Arg Thr 
225                 230                 235                 240 


Glu Ser Tyr Arg Asp Phe Ile Tyr Gln Asn Pro His Ile Phe Lys Asp 
                245                 250                 255     


Lys Val Val Leu Asp Val Gly Cys Gly Thr Gly Ile Leu Ser Met Phe 
            260                 265                 270         


Ala Ala Lys Ala Gly Ala Lys Lys Val Leu Gly Val Asp Gln Ser Glu 
        275                 280                 285             


Ile Leu Tyr Gln Ala Met Asp Ile Ile Arg Leu Asn Lys Leu Glu Asp 
    290                 295                 300                 


Thr Ile Thr Leu Ile Lys Gly Lys Ile Glu Glu Val His Leu Pro Val 
305                 310                 315                 320 


Glu Lys Val Asp Val Ile Ile Ser Glu Trp Met Gly Tyr Phe Leu Leu 
                325                 330                 335     


Phe Glu Ser Met Leu Asp Ser Val Leu Tyr Ala Lys Asn Lys Tyr Leu 
            340                 345                 350         


Ala Lys Gly Gly Ser Val Tyr Pro Asp Ile Cys Thr Ile Ser Leu Val 
        355                 360                 365             


Ala Val Ser Asp Val Asn Lys His Ala Asp Arg Ile Ala Phe Trp Asp 
    370                 375                 380                 


Asp Val Tyr Gly Phe Lys Met Ser Cys Met Lys Lys Ala Val Ile Pro 
385                 390                 395                 400 


Glu Ala Val Val Glu Val Leu Asp Pro Lys Thr Leu Ile Ser Glu Pro 
                405                 410                 415     


Cys Gly Ile Lys His Ile Asp Cys His Thr Thr Ser Ile Ser Asp Leu 
            420                 425                 430         


Glu Phe Ser Ser Asp Phe Thr Leu Lys Ile Thr Arg Thr Ser Met Cys 
        435                 440                 445             


Thr Ala Ile Ala Gly Tyr Phe Asp Ile Tyr Phe Glu Lys Asn Cys His 
    450                 455                 460                 


Asn Arg Val Val Phe Ser Thr Gly Pro Gln Ser Thr Lys Thr His Trp 
465                 470                 475                 480 


Lys Gln Thr Val Phe Leu Leu Glu Lys Pro Phe Ser Val Lys Ala Gly 
                485                 490                 495     


Glu Ala Leu Lys Gly Lys Val Thr Val His Lys Asn Lys Lys Asp Pro 
            500                 505                 510         


Arg Ser Leu Thr Val Thr Leu Thr Leu Asn Asn Ser Thr Gln Thr Tyr 
        515                 520                 525             


Gly Leu Gln 
    530     


<210>  2644
<211>  2863
<212>  DNA
<213>  Homosapiens

<400>  2644
cacgccaaac acgcagcccc ctcccgctgg agtgacaact ggccagcata ctctaggctg     60

ttgtcccttt aaaacttgaa tccaaggggg taatgattta tcaaacttgt attatcaaga    120

aaatgtcaaa ccaagggcac cttgctttgc actgacgcaa acccggcctt tcccaaggag    180

atatagaaag cgcctctcct gcctgagcca aacccagtct tgtcaatagc gggtttcacc    240

ctccaccagt tcagtctgtt gcctgtgtca gacatggatt gcagtgctcc caaggaaatg    300

aataaactgc cagccaacag cccggaggcg gcggcggcgc agggccaccc ggatggccca    360

tgcgctccca ggacgagccc ggagcaggag cttcccgcgg ctgccgcccc gccgccgcca    420

cgtgtgccca ggtccgcttc caccggcgcc caaactttcc agtcagcgga cgcgcgagcc    480

tgcgaggctg agcggccagg agtggggtct tgcaaactca gtagcccgcg ggcgcaggcg    540

gcctctgcag ctctgcggga cttgagagag gcgcaaggcg cgcaggcctc gccccctccc    600

gggagctccg ggcccggcaa cgcgctgcac tgtaagatcc cttttctgcg aggcccggag    660

ggggatgcga acgtgagtgt gggcaagggc accctggagc ggaacaatac ccctgttgtg    720

ggctgggtga acatgagcca gagcaccgtg gtgctggcca cggatggaat cacgtccgtg    780

ctcccgggca gcgtggccac cgttgccacc caggaggacg agcaagggga tgagaataag    840

gcccgaggga actggtccag caaactggac ttcatcctgt ccatggtggg gtacgcagtg    900

gggctgggca atgtctggag gtttccctac ctggccttcc agaacggggg aggtgctttc    960

ctcatccctt acctgatgat gctggctctg gctggattac ccatcttctt cttggaggtg   1020

tcgctgggcc agtttgccag ccagggacca gtgtctgtgt ggaaggccat cccagctcta   1080

caaggctgtg gcatcgcgat gctgatcatc tctgtcctaa tagccatata ctacaatgtg   1140

attatttgct atacactttt ctacctgttt gcctcctttg tgtctgtact accctggggc   1200

tcctgcaaca acccttggaa tacgccagaa tgcaaagata aaaccaaact tttattagat   1260

tcctgtgtta tcagtgacca tcccaaaata cagatcaaga actcgacttt ctgcatgacc   1320

gcttatccca acgtgacaat ggttaatttc accagccagg ccaataagac atttgtcagt   1380

ggaagtgaag agtacttcaa gtactttgtg ctgaagattt ctgcagggat tgaatatcct   1440

ggcgagatca ggtggccact agctctctgc ctcttcctgg cttgggtcat tgtgtatgca   1500

tcattggcta aaggaatcaa gacttcagga aaagtggtgt acttcacggc cacgttcccg   1560

tatgtcgtac tcgtgatcct cctcatccga ggagtcaccc tgcctggagc tggagctggg   1620

atctggtact tcatcacacc caagtgggag aaactcacgg atgccacggt gtggaaagat   1680

gctgccactc agattttctt ctctttatct gctgcatggg gaggcctgat cactctctct   1740

tcttacaaca aattccacaa caactgctac agggacactc taattgtcac ctgcaccaac   1800

agtgccacaa gcatctttgc cggcttcgtc atcttctccg ttatcggctt catggccaat   1860

gaacgcaaag tcaacattga gaatgtggca gaccaagggc caggcattgc atttgtggtt   1920

tacccggaag ccttaaccag gctgcctctc tctccgttct gggccatcat ctttttcctg   1980

atgctcctca ctcttggact tgacactatg tttgccacca tcgagaccat agtgacctcc   2040

atctcagacg agtttcccaa gtacctacgc acacacaagc cagtgtttac tctgggctgc   2100

tgcatttgtt tcttcatcat gggttttcca atgatcactc agggtggaat ttacatgttt   2160

cagcttgtgg acacctatgc tgcctcctat gcccttgtca tcattgccat ttttgagctc   2220

gtggggatct cttatgtgta tggcttgcaa agattctgtg aagatataga gatgatgatt   2280

ggattccagc ctaacatctt ctggaaagtc tgctgggcat ttgtaacccc aaccatttta   2340

acctttatcc tttgcttcag cttttaccag tgggagccca tgacctatgg ctcttaccgc   2400

tatcctaact ggtccatggt gctcggatgg ctaatgctcg cctgttccgt catctggatc   2460

ccaattatgt ttgtgataaa aatgcatctg gcccctggaa gatttattga gaggctgaag   2520

ttggtgtgct cgccacagcc ggactggggc ccattcttag ctcaacaccg cggggagcgt   2580

tacaagaaca tgatcgaccc cttgggaacc tcttccttgg gactcaaact gccagtgaag   2640

gatttggaac tgggcactca gtgctagtcc agtggtgtgg gatggtccag acttgatcct   2700

gtttttcctc tctgcctcct cctaatgttt tccatagctc tcctcccatt tttcttcatc   2760

tttcttccta catcttggtt cacatccacg catgagagtg attatgtaga aaagtaggca   2820

tagtgtcgca tgctgcagta aagagctaca tagaccacct gaa                     2863


<210>  2645
<211>  797
<212>  PRT
<213>  Homosapiens

<400>  2645

Met Asp Cys Ser Ala Pro Lys Glu Met Asn Lys Leu Pro Ala Asn Ser 
1               5                   10                  15      


Pro Glu Ala Ala Ala Ala Gln Gly His Pro Asp Gly Pro Cys Ala Pro 
            20                  25                  30          


Arg Thr Ser Pro Glu Gln Glu Leu Pro Ala Ala Ala Ala Pro Pro Pro 
        35                  40                  45              


Pro Arg Val Pro Arg Ser Ala Ser Thr Gly Ala Gln Thr Phe Gln Ser 
    50                  55                  60                  


Ala Asp Ala Arg Ala Cys Glu Ala Glu Arg Pro Gly Val Gly Ser Cys 
65                  70                  75                  80  


Lys Leu Ser Ser Pro Arg Ala Gln Ala Ala Ser Ala Ala Leu Arg Asp 
                85                  90                  95      


Leu Arg Glu Ala Gln Gly Ala Gln Ala Ser Pro Pro Pro Gly Ser Ser 
            100                 105                 110         


Gly Pro Gly Asn Ala Leu His Cys Lys Ile Pro Phe Leu Arg Gly Pro 
        115                 120                 125             


Glu Gly Asp Ala Asn Val Ser Val Gly Lys Gly Thr Leu Glu Arg Asn 
    130                 135                 140                 


Asn Thr Pro Val Val Gly Trp Val Asn Met Ser Gln Ser Thr Val Val 
145                 150                 155                 160 


Leu Ala Thr Asp Gly Ile Thr Ser Val Leu Pro Gly Ser Val Ala Thr 
                165                 170                 175     


Val Ala Thr Gln Glu Asp Glu Gln Gly Asp Glu Asn Lys Ala Arg Gly 
            180                 185                 190         


Asn Trp Ser Ser Lys Leu Asp Phe Ile Leu Ser Met Val Gly Tyr Ala 
        195                 200                 205             


Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Ala Phe Gln Asn 
    210                 215                 220                 


Gly Gly Gly Ala Phe Leu Ile Pro Tyr Leu Met Met Leu Ala Leu Ala 
225                 230                 235                 240 


Gly Leu Pro Ile Phe Phe Leu Glu Val Ser Leu Gly Gln Phe Ala Ser 
                245                 250                 255     


Gln Gly Pro Val Ser Val Trp Lys Ala Ile Pro Ala Leu Gln Gly Cys 
            260                 265                 270         


Gly Ile Ala Met Leu Ile Ile Ser Val Leu Ile Ala Ile Tyr Tyr Asn 
        275                 280                 285             


Val Ile Ile Cys Tyr Thr Leu Phe Tyr Leu Phe Ala Ser Phe Val Ser 
    290                 295                 300                 


Val Leu Pro Trp Gly Ser Cys Asn Asn Pro Trp Asn Thr Pro Glu Cys 
305                 310                 315                 320 


Lys Asp Lys Thr Lys Leu Leu Leu Asp Ser Cys Val Ile Ser Asp His 
                325                 330                 335     


Pro Lys Ile Gln Ile Lys Asn Ser Thr Phe Cys Met Thr Ala Tyr Pro 
            340                 345                 350         


Asn Val Thr Met Val Asn Phe Thr Ser Gln Ala Asn Lys Thr Phe Val 
        355                 360                 365             


Ser Gly Ser Glu Glu Tyr Phe Lys Tyr Phe Val Leu Lys Ile Ser Ala 
    370                 375                 380                 


Gly Ile Glu Tyr Pro Gly Glu Ile Arg Trp Pro Leu Ala Leu Cys Leu 
385                 390                 395                 400 


Phe Leu Ala Trp Val Ile Val Tyr Ala Ser Leu Ala Lys Gly Ile Lys 
                405                 410                 415     


Thr Ser Gly Lys Val Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val 
            420                 425                 430         


Leu Val Ile Leu Leu Ile Arg Gly Val Thr Leu Pro Gly Ala Gly Ala 
        435                 440                 445             


Gly Ile Trp Tyr Phe Ile Thr Pro Lys Trp Glu Lys Leu Thr Asp Ala 
    450                 455                 460                 


Thr Val Trp Lys Asp Ala Ala Thr Gln Ile Phe Phe Ser Leu Ser Ala 
465                 470                 475                 480 


Ala Trp Gly Gly Leu Ile Thr Leu Ser Ser Tyr Asn Lys Phe His Asn 
                485                 490                 495     


Asn Cys Tyr Arg Asp Thr Leu Ile Val Thr Cys Thr Asn Ser Ala Thr 
            500                 505                 510         


Ser Ile Phe Ala Gly Phe Val Ile Phe Ser Val Ile Gly Phe Met Ala 
        515                 520                 525             


Asn Glu Arg Lys Val Asn Ile Glu Asn Val Ala Asp Gln Gly Pro Gly 
    530                 535                 540                 


Ile Ala Phe Val Val Tyr Pro Glu Ala Leu Thr Arg Leu Pro Leu Ser 
545                 550                 555                 560 


Pro Phe Trp Ala Ile Ile Phe Phe Leu Met Leu Leu Thr Leu Gly Leu 
                565                 570                 575     


Asp Thr Met Phe Ala Thr Ile Glu Thr Ile Val Thr Ser Ile Ser Asp 
            580                 585                 590         


Glu Phe Pro Lys Tyr Leu Arg Thr His Lys Pro Val Phe Thr Leu Gly 
        595                 600                 605             


Cys Cys Ile Cys Phe Phe Ile Met Gly Phe Pro Met Ile Thr Gln Gly 
    610                 615                 620                 


Gly Ile Tyr Met Phe Gln Leu Val Asp Thr Tyr Ala Ala Ser Tyr Ala 
625                 630                 635                 640 


Leu Val Ile Ile Ala Ile Phe Glu Leu Val Gly Ile Ser Tyr Val Tyr 
                645                 650                 655     


Gly Leu Gln Arg Phe Cys Glu Asp Ile Glu Met Met Ile Gly Phe Gln 
            660                 665                 670         


Pro Asn Ile Phe Trp Lys Val Cys Trp Ala Phe Val Thr Pro Thr Ile 
        675                 680                 685             


Leu Thr Phe Ile Leu Cys Phe Ser Phe Tyr Gln Trp Glu Pro Met Thr 
    690                 695                 700                 


Tyr Gly Ser Tyr Arg Tyr Pro Asn Trp Ser Met Val Leu Gly Trp Leu 
705                 710                 715                 720 


Met Leu Ala Cys Ser Val Ile Trp Ile Pro Ile Met Phe Val Ile Lys 
                725                 730                 735     


Met His Leu Ala Pro Gly Arg Phe Ile Glu Arg Leu Lys Leu Val Cys 
            740                 745                 750         


Ser Pro Gln Pro Asp Trp Gly Pro Phe Leu Ala Gln His Arg Gly Glu 
        755                 760                 765             


Arg Tyr Lys Asn Met Ile Asp Pro Leu Gly Thr Ser Ser Leu Gly Leu 
    770                 775                 780                 


Lys Leu Pro Val Lys Asp Leu Glu Leu Gly Thr Gln Cys 
785                 790                 795         


<210>  2646
<211>  3147
<212>  DNA
<213>  Homosapiens

<400>  2646
agagcgccca ggagcgctac cggctgaggg tggggaagcg cagggccaag cgcgcgaagc     60

aggttgtggg ggaccgggtc gagtggaagt acccgccgga gaggaaggcc ggctggctgt    120

ggcgcccaga gacggtggag tccgaggagg aggagaagga ggcctgcaga aggaagagca    180

ggcccttaga agtccagcag cagcaactcc ggcggcccac agtcagattc agcacctgcc    240

tcagatctcc acgtctgtct cagctgcccc tctcctgctg cctctcaggc accagtgcca    300

ttaacgagct ggcgaagatg ggcgacccgg atctcctgga agtgttggcg gaggaagggg    360

aaaaagtcaa taagcatata gactactctt tccaaatgag tgagcagagc ctgagcagca    420

gagagaccag ctttctcatc aatgaagaaa caatgcctgc aaagcgattc aatttgttcc    480

tgaggcggcg gcttatgttt caaaaaaatc agcaaagcaa agattctatc ttcttccgag    540

atgggattag gcaaattgat tttgtgcttt cctacgttga tgacgtaaag aaagacgcag    600

agttaaaggc ggaaagaaga aaagagtttg aaactaatct cagaaaaaca ggtcttgagt    660

tggaaataga agacaaaagg gactcggaag atggaagaac ttattttgtc aagatccatg    720

ccccttggga ggtattagtt acctatgctg aagtcttggg aatcaaaatg cctattaagg    780

agagtgatat tccccgccct aagcacactc ctataagcta tgtgcttgga cctgtaagac    840

tcccactgag tgtgaagtat ccccatcctg aatattttac tgcacaattc agcagacatc    900

ggcaggagct cttcctcatc gaagatcagg caaccttctt tccatcctca tcaagaaaca    960

gaattgtgta ctatattctc tcaagatgtc cttttggcat agaagatggg aagaaaaggt   1020

ttgggattga aagactgcta aactctaaca cttactcatc tgcctatcca ctccatgatg   1080

gccaatattg gaagccatca gaacctccca atcctaccaa tgaaagatac acacttcacc   1140

agaattgggc tcgattttcc tatttctaca aggagcagcc tttagacttg attaagaatt   1200

attatggaga aaaaattggt atctattttg tctttcttgg attttacaca gaaatgctat   1260

tctttgcagc tgtagttggc ttagcttgtt ttatttatgg cttattatca atggaacata   1320

acacaagcag cactgaaatc tgtgaccctg agattggtgg tcagatgatc atgtgcccac   1380

tctgtgatca agtgtgtgat tattggagac taaatagtac gtgtttggct tcaaagttct   1440

cccatttgtt tgataatgag tcaacagtgt tctttgcaat attcatggga atttgggtca   1500

ccttattttt ggagttttgg aaacaacgac aagccagact ggaatatgaa tgggacctgg   1560

tggactttga agaggaacag cagcagcttc agctgagacc agaatttgaa gctatgtgta   1620

aacacaggaa attgaatgca gtgactaagg agatggaacc ttacatgcct ctatacacgc   1680

gtattccatg gtactttctt tcaggagcca cagtgacatt atggatgtct cttgtcgtca   1740

ccagtatggt agctgtaatt gtgtaccgcc tgtcagtctt tgctacattt gctagtttca   1800

tggaaagtga tgcatcctta aagcaggtca aaagcttcct tactcctcag ataaccacat   1860

cactcacagg atcatgcttg aactttattg tcatcttgat cttgaatttc ttttatgaaa   1920

agatatctgc ctggatcaca aaaatggaaa ttcctcgaac ataccaggag tatgagagca   1980

gtcttacctt gaaaatgttc ctgtttcagt ttgtaaattt ttactcatcc tgcttctacg   2040

tagctttctt taaagggaag ttcgtaggct atcctggaaa atacacatat ttatttaatg   2100

agtggagaag tgaagagtgt gatcctggag gctgtcttat agaattgaca acccaattga   2160

ccattataat gaccgggaaa cagatttttg gaaacattaa agaagccatt tatcccttgg   2220

ctttgaattg gtggagacgc cgaaaagctc ggacaaactc tgagaagctg tatagtcgat   2280

gggagcagga tcatgacctt gaaagttttg gaccccttgg gcttttctat gagtacttag   2340

aaacagttac tcaatttgga tttgttacac tatttgtggc ctcttttcct ttggctcctc   2400

ttcttgctct cataaataat attgtagaga ttcgagtgga tgcctggaaa cttaccactc   2460

aatacaggag aactgtagct tctaaagctc atagcatagg tgtttggcaa gacattcttt   2520

atggaatggc tgtcctttct gttgcaacta atgcctttat tgttgcattt acgtcagaca   2580

tcattccccg tctagtttac tactatgctt actcaacaaa tgccacacag cctatgacag   2640

gatatgtgaa taatagcctg tcagtattcc tgatagctga ttttccaaac cacactgcac   2700

cttcggaaaa acgagacttc atcacttgca ggtacagaga ttacagatat cctcctgatg   2760

acgagaataa atattttcat aatatgcaat tctggcatgt ccttgctgcc aagatgacct   2820

tcatcattgt tatggaacat gttgtgtttt tagttaaatt tttgctggcc tggatgatac   2880

ctgatgttcc aaaagatgtt gtggagagaa tcaagagaga aaagttaatg actatcaaga   2940

ttctccatga ttttgagctc aacaaattaa aagagaactt gggaattaat tctaatgaat   3000

ttgccaagca tgtcatgatt gaggaaaaca aagcacagct ggctaaatca acactctaat   3060

cagtatagtg aggaagcagc aggtgatctg ccttacttca ctttatcctc tggttttagg   3120

gccagacgcc agaagccatg tgtcaat                                       3147


<210>  2647
<211>  913
<212>  PRT
<213>  Homosapiens

<400>  2647

Met Gly Asp Pro Asp Leu Leu Glu Val Leu Ala Glu Glu Gly Glu Lys 
1               5                   10                  15      


Val Asn Lys His Ile Asp Tyr Ser Phe Gln Met Ser Glu Gln Ser Leu 
            20                  25                  30          


Ser Ser Arg Glu Thr Ser Phe Leu Ile Asn Glu Glu Thr Met Pro Ala 
        35                  40                  45              


Lys Arg Phe Asn Leu Phe Leu Arg Arg Arg Leu Met Phe Gln Lys Asn 
    50                  55                  60                  


Gln Gln Ser Lys Asp Ser Ile Phe Phe Arg Asp Gly Ile Arg Gln Ile 
65                  70                  75                  80  


Asp Phe Val Leu Ser Tyr Val Asp Asp Val Lys Lys Asp Ala Glu Leu 
                85                  90                  95      


Lys Ala Glu Arg Arg Lys Glu Phe Glu Thr Asn Leu Arg Lys Thr Gly 
            100                 105                 110         


Leu Glu Leu Glu Ile Glu Asp Lys Arg Asp Ser Glu Asp Gly Arg Thr 
        115                 120                 125             


Tyr Phe Val Lys Ile His Ala Pro Trp Glu Val Leu Val Thr Tyr Ala 
    130                 135                 140                 


Glu Val Leu Gly Ile Lys Met Pro Ile Lys Glu Ser Asp Ile Pro Arg 
145                 150                 155                 160 


Pro Lys His Thr Pro Ile Ser Tyr Val Leu Gly Pro Val Arg Leu Pro 
                165                 170                 175     


Leu Ser Val Lys Tyr Pro His Pro Glu Tyr Phe Thr Ala Gln Phe Ser 
            180                 185                 190         


Arg His Arg Gln Glu Leu Phe Leu Ile Glu Asp Gln Ala Thr Phe Phe 
        195                 200                 205             


Pro Ser Ser Ser Arg Asn Arg Ile Val Tyr Tyr Ile Leu Ser Arg Cys 
    210                 215                 220                 


Pro Phe Gly Ile Glu Asp Gly Lys Lys Arg Phe Gly Ile Glu Arg Leu 
225                 230                 235                 240 


Leu Asn Ser Asn Thr Tyr Ser Ser Ala Tyr Pro Leu His Asp Gly Gln 
                245                 250                 255     


Tyr Trp Lys Pro Ser Glu Pro Pro Asn Pro Thr Asn Glu Arg Tyr Thr 
            260                 265                 270         


Leu His Gln Asn Trp Ala Arg Phe Ser Tyr Phe Tyr Lys Glu Gln Pro 
        275                 280                 285             


Leu Asp Leu Ile Lys Asn Tyr Tyr Gly Glu Lys Ile Gly Ile Tyr Phe 
    290                 295                 300                 


Val Phe Leu Gly Phe Tyr Thr Glu Met Leu Phe Phe Ala Ala Val Val 
305                 310                 315                 320 


Gly Leu Ala Cys Phe Ile Tyr Gly Leu Leu Ser Met Glu His Asn Thr 
                325                 330                 335     


Ser Ser Thr Glu Ile Cys Asp Pro Glu Ile Gly Gly Gln Met Ile Met 
            340                 345                 350         


Cys Pro Leu Cys Asp Gln Val Cys Asp Tyr Trp Arg Leu Asn Ser Thr 
        355                 360                 365             


Cys Leu Ala Ser Lys Phe Ser His Leu Phe Asp Asn Glu Ser Thr Val 
    370                 375                 380                 


Phe Phe Ala Ile Phe Met Gly Ile Trp Val Thr Leu Phe Leu Glu Phe 
385                 390                 395                 400 


Trp Lys Gln Arg Gln Ala Arg Leu Glu Tyr Glu Trp Asp Leu Val Asp 
                405                 410                 415     


Phe Glu Glu Glu Gln Gln Gln Leu Gln Leu Arg Pro Glu Phe Glu Ala 
            420                 425                 430         


Met Cys Lys His Arg Lys Leu Asn Ala Val Thr Lys Glu Met Glu Pro 
        435                 440                 445             


Tyr Met Pro Leu Tyr Thr Arg Ile Pro Trp Tyr Phe Leu Ser Gly Ala 
    450                 455                 460                 


Thr Val Thr Leu Trp Met Ser Leu Val Val Thr Ser Met Val Ala Val 
465                 470                 475                 480 


Ile Val Tyr Arg Leu Ser Val Phe Ala Thr Phe Ala Ser Phe Met Glu 
                485                 490                 495     


Ser Asp Ala Ser Leu Lys Gln Val Lys Ser Phe Leu Thr Pro Gln Ile 
            500                 505                 510         


Thr Thr Ser Leu Thr Gly Ser Cys Leu Asn Phe Ile Val Ile Leu Ile 
        515                 520                 525             


Leu Asn Phe Phe Tyr Glu Lys Ile Ser Ala Trp Ile Thr Lys Met Glu 
    530                 535                 540                 


Ile Pro Arg Thr Tyr Gln Glu Tyr Glu Ser Ser Leu Thr Leu Lys Met 
545                 550                 555                 560 


Phe Leu Phe Gln Phe Val Asn Phe Tyr Ser Ser Cys Phe Tyr Val Ala 
                565                 570                 575     


Phe Phe Lys Gly Lys Phe Val Gly Tyr Pro Gly Lys Tyr Thr Tyr Leu 
            580                 585                 590         


Phe Asn Glu Trp Arg Ser Glu Glu Cys Asp Pro Gly Gly Cys Leu Ile 
        595                 600                 605             


Glu Leu Thr Thr Gln Leu Thr Ile Ile Met Thr Gly Lys Gln Ile Phe 
    610                 615                 620                 


Gly Asn Ile Lys Glu Ala Ile Tyr Pro Leu Ala Leu Asn Trp Trp Arg 
625                 630                 635                 640 


Arg Arg Lys Ala Arg Thr Asn Ser Glu Lys Leu Tyr Ser Arg Trp Glu 
                645                 650                 655     


Gln Asp His Asp Leu Glu Ser Phe Gly Pro Leu Gly Leu Phe Tyr Glu 
            660                 665                 670         


Tyr Leu Glu Thr Val Thr Gln Phe Gly Phe Val Thr Leu Phe Val Ala 
        675                 680                 685             


Ser Phe Pro Leu Ala Pro Leu Leu Ala Leu Ile Asn Asn Ile Val Glu 
    690                 695                 700                 


Ile Arg Val Asp Ala Trp Lys Leu Thr Thr Gln Tyr Arg Arg Thr Val 
705                 710                 715                 720 


Ala Ser Lys Ala His Ser Ile Gly Val Trp Gln Asp Ile Leu Tyr Gly 
                725                 730                 735     


Met Ala Val Leu Ser Val Ala Thr Asn Ala Phe Ile Val Ala Phe Thr 
            740                 745                 750         


Ser Asp Ile Ile Pro Arg Leu Val Tyr Tyr Tyr Ala Tyr Ser Thr Asn 
        755                 760                 765             


Ala Thr Gln Pro Met Thr Gly Tyr Val Asn Asn Ser Leu Ser Val Phe 
    770                 775                 780                 


Leu Ile Ala Asp Phe Pro Asn His Thr Ala Pro Ser Glu Lys Arg Asp 
785                 790                 795                 800 


Phe Ile Thr Cys Arg Tyr Arg Asp Tyr Arg Tyr Pro Pro Asp Asp Glu 
                805                 810                 815     


Asn Lys Tyr Phe His Asn Met Gln Phe Trp His Val Leu Ala Ala Lys 
            820                 825                 830         


Met Thr Phe Ile Ile Val Met Glu His Val Val Phe Leu Val Lys Phe 
        835                 840                 845             


Leu Leu Ala Trp Met Ile Pro Asp Val Pro Lys Asp Val Val Glu Arg 
    850                 855                 860                 


Ile Lys Arg Glu Lys Leu Met Thr Ile Lys Ile Leu His Asp Phe Glu 
865                 870                 875                 880 


Leu Asn Lys Leu Lys Glu Asn Leu Gly Ile Asn Ser Asn Glu Phe Ala 
                885                 890                 895     


Lys His Val Met Ile Glu Glu Asn Lys Ala Gln Leu Ala Lys Ser Thr 
            900                 905                 910         


Leu 
    


<210>  2648
<211>  3946
<212>  DNA
<213>  Homosapiens

<400>  2648
cgtttaaaag ccatcagatt tgagagcaat aagtcttcaa aaccgggaat ttacattgtt     60

tttcagctga ccgacttcca ggaaaaggac tcaaccgcat ctacccaaat accgtggcac    120

tgcttgcgct ctttgccacc ggatactccc cttccaatga gactttctga ttgtgtctac    180

caactctcct attaggaaac ccgtgggttg catgcagcta ttctgttgta ttctcattct    240

cactctccct cccttctctc actctcactc ttgctggagg cgagccacta ccattctgct    300

gagaaggaaa agcccgcaac tactttaaga gattaagaca atatgcgcaa tcctcgcctt    360

tcctagcaat cactatttaa atctggcaag aactgacaac agtctttgca agaatggaat    420

ccgtaaaaca aaggattttg gccccaggaa aagaggggct aaagaatttt gctggaaaat    480

cactcggcca gatctacagg gtgctggaga agaagcaaga caccggggag acaatcgagc    540

tgacggagga tgggaagccc ctagaggtgc ccgagaggaa ggcgccgctg tgcgactgca    600

cgtgcttcgg cctgccccgc cgctacatta tcgccatcat gagcggcctg ggcttctgca    660

tctccttcgg tatccgctgc aacctgggcg tggccattgt ggacatggtc aacaacagca    720

ccatccaccg cgggggcaag gtcatcaagg agaaagccaa attcaactgg gacccggaaa    780

ccgtggggat gatccacggt tccttctttt ggggctacat catcactcag attccgggag    840

gctacatcgc gtctcggctg gcagccaaca gggttttcgg agctgccata cttcttacct    900

ctaccctaaa tatgctaatt ccatcagcag ccagagtgca ttatggatgt gtcatctttg    960

tcagaatact gcagggactt gttgagggtg tgacctaccc agcatgtcat gggatatgga   1020

gcaaatgggc cccacctcta gagaggagta gactggcaac cacctccttt tgtggttcct   1080

atgccggagc tgtgattgca atgcctttag ctggcattct tgtgcagtac actggctggt   1140

cttcagtgtt ttatgtctac ggaagctttg gaatggtctg gtacatgttt tggcttttgg   1200

tgtcttatga aagtcctgca aagcatccta ctattacaga tgaagaacgt aggtacatag   1260

aagaaagcat tggagagagt gcaaatcttt taggtgcaat ggaaaaattc aagactccat   1320

ggaggaagtt ttttacatcc atgccagtct atgcaataat tgttgcaaac ttctgcagaa   1380

gctggacttt ttatttattg cttattagtc agccagcata ttttgaggaa gtctttggat   1440

ttgaaattag caaggttggt atgctatctg ctgtgccaca cttagtaatg acaattattg   1500

tgcctattgg gggacaaatt gcagattttc taagaagcaa gcagattctt tcaactacga   1560

cagtgagaaa gatcatgaat tgtggtggtt ttggcatgga agccacactg ctcctggtcg   1620

ttggctattc tcatactaga ggggtagcaa tctcattctt ggtacttgca gtgggattca   1680

gtggatttgc tatatctggt ttcaatgtta accacttgga tatcgctcca agatatgcca   1740

gtatcttaat gggcatttcg aatggtgttg gcacattgtc aggaatggtt tgtcctatca   1800

ttgttggtgc aatgacaaag aataagtcac gtgaagagtg gcagtatgtc ttcctgatcg   1860

ctgccctagt ccactatggt ggagttatat tttatgcaat atttgcctca ggagagaaac   1920

aaccctgggc agacccggag gaaacaagtg aagaaaaatg tggatttatt catgaagatg   1980

aactcgatga agaaacaggg gacattactc aaaattatat aaattatggt accaccaagt   2040

cttatggtgc cacaacacag gccaatggag gttggcctag tggttgggaa aagaaagagg   2100

aatttgtaca aggagaagta caagactcac atagctataa ggaccgagtt gattattcat   2160

aacaaaacta attactggat ttatttttag tgtttgtgat taaattcatt gtgattgcac   2220

aaaaatttta aaaacacgtg atgtaaactt gcaagcatat caaccaggca agtcttgctg   2280

taaaaatgaa aacaaaacaa acccatgagg ttaccatcaa gtgcaatctg taaaattgtg   2340

aagttccatc atttccattc aagtcatcca ttcttgcatt tgtgacttaa aggttgactg   2400

gtcaaaattg tagaaacaag tagttaccca ttggattcat atgagctaaa actcatcact   2460

atttactaaa gcacaacatc tcatcctaca aaagttaaga agccaaagct acttgatcat   2520

gcaaaatgca cttatatatt tgttacactg tattgcaaga tagcacacag aagttggctg   2580

cgtcaagtag aggcgacatt tattaagtga aaatcatgga gttgggatat ctctcaatta   2640

aagaaataca ttgtgaacta tcagctacaa agttgtactg aataactatt agaattgcat   2700

aatgtgagat attttgttag tcctcaaaag gaatatcttg cagtgttttc tatgaaatgc   2760

ttgggcacaa acacttattt ctgtgaaaga gaacatgtaa gttgaggggt atgcttcatg   2820

ttcttccatc catttaccta atagtatgaa acagttcaca tttcaataaa atcaaacttt   2880

tcatgtagcg tatcacataa cttttttgca aaaaatataa aaagaaataa acttcaatgt   2940

attttttatt acaactttgt actggttgta acttgcatta gaaaaaaaaa agagatatat   3000

aaaccacaaa gaatctaata agaaatttat tatggagata tagcccttaa aatgcaatat   3060

taagaacaaa gaaatagaaa atggtttaga tatctttctt ccttcataat taaatactat   3120

atgaaacttg tgccacagag ctatatgtaa tatgaaaaga ttaacttcat agagatattg   3180

taagtaggta attttattat ttaaagtcct attaagaaat atttgtctta aatatatagg   3240

acaatacatt atattaaaat ggtctctctc tatatatatc tgtatatctt atacatgtcc   3300

atacacagaa acataataaa caatcttcac acgaaaccaa aaatagcata cacctaatgt   3360

tgggttaggg aattgcaatt tctactttca tagagtcata gaattttagg tggggaagag   3420

gcattttgct tgtcatttct taatataact caacaagaat tgcaacattt gtgtaccaag   3480

caataagtgc aatgcataaa atttcctgtc tgtatattac cttcattttg cttgtagtag   3540

ctgtttgggt ggttggaata attttatttt tcttttaaaa aagctaacat cagacccctt   3600

tataatgtcc taaaattatg ataatacatt tcccaattca actcaaaata ttattggtgt   3660

attttgtcta ttctggatat ttgatctgtt taatgtactg tgctagtgac tggaggccct   3720

gctactgcaa atataaaacc taaagtttgt ttaaaaaaat gcaaatcatt ctttacctta   3780

agaaaaaaaa aatacccttt gctttgtgcc tcaaagtgat gtaatgtgat cacagctttt   3840

gttgtgttga atgaaaatat gtggactgtc attttgttgc agcaaaaaag tgttaataaa   3900

atgctctatt tatccttttt taaaaaaaaa aaaaaaaaaa aaaaaa                  3946


<210>  2649
<211>  582
<212>  PRT
<213>  Homosapiens

<400>  2649

Met Glu Ser Val Lys Gln Arg Ile Leu Ala Pro Gly Lys Glu Gly Leu 
1               5                   10                  15      


Lys Asn Phe Ala Gly Lys Ser Leu Gly Gln Ile Tyr Arg Val Leu Glu 
            20                  25                  30          


Lys Lys Gln Asp Thr Gly Glu Thr Ile Glu Leu Thr Glu Asp Gly Lys 
        35                  40                  45              


Pro Leu Glu Val Pro Glu Arg Lys Ala Pro Leu Cys Asp Cys Thr Cys 
    50                  55                  60                  


Phe Gly Leu Pro Arg Arg Tyr Ile Ile Ala Ile Met Ser Gly Leu Gly 
65                  70                  75                  80  


Phe Cys Ile Ser Phe Gly Ile Arg Cys Asn Leu Gly Val Ala Ile Val 
                85                  90                  95      


Asp Met Val Asn Asn Ser Thr Ile His Arg Gly Gly Lys Val Ile Lys 
            100                 105                 110         


Glu Lys Ala Lys Phe Asn Trp Asp Pro Glu Thr Val Gly Met Ile His 
        115                 120                 125             


Gly Ser Phe Phe Trp Gly Tyr Ile Ile Thr Gln Ile Pro Gly Gly Tyr 
    130                 135                 140                 


Ile Ala Ser Arg Leu Ala Ala Asn Arg Val Phe Gly Ala Ala Ile Leu 
145                 150                 155                 160 


Leu Thr Ser Thr Leu Asn Met Leu Ile Pro Ser Ala Ala Arg Val His 
                165                 170                 175     


Tyr Gly Cys Val Ile Phe Val Arg Ile Leu Gln Gly Leu Val Glu Gly 
            180                 185                 190         


Val Thr Tyr Pro Ala Cys His Gly Ile Trp Ser Lys Trp Ala Pro Pro 
        195                 200                 205             


Leu Glu Arg Ser Arg Leu Ala Thr Thr Ser Phe Cys Gly Ser Tyr Ala 
    210                 215                 220                 


Gly Ala Val Ile Ala Met Pro Leu Ala Gly Ile Leu Val Gln Tyr Thr 
225                 230                 235                 240 


Gly Trp Ser Ser Val Phe Tyr Val Tyr Gly Ser Phe Gly Met Val Trp 
                245                 250                 255     


Tyr Met Phe Trp Leu Leu Val Ser Tyr Glu Ser Pro Ala Lys His Pro 
            260                 265                 270         


Thr Ile Thr Asp Glu Glu Arg Arg Tyr Ile Glu Glu Ser Ile Gly Glu 
        275                 280                 285             


Ser Ala Asn Leu Leu Gly Ala Met Glu Lys Phe Lys Thr Pro Trp Arg 
    290                 295                 300                 


Lys Phe Phe Thr Ser Met Pro Val Tyr Ala Ile Ile Val Ala Asn Phe 
305                 310                 315                 320 


Cys Arg Ser Trp Thr Phe Tyr Leu Leu Leu Ile Ser Gln Pro Ala Tyr 
                325                 330                 335     


Phe Glu Glu Val Phe Gly Phe Glu Ile Ser Lys Val Gly Met Leu Ser 
            340                 345                 350         


Ala Val Pro His Leu Val Met Thr Ile Ile Val Pro Ile Gly Gly Gln 
        355                 360                 365             


Ile Ala Asp Phe Leu Arg Ser Lys Gln Ile Leu Ser Thr Thr Thr Val 
    370                 375                 380                 


Arg Lys Ile Met Asn Cys Gly Gly Phe Gly Met Glu Ala Thr Leu Leu 
385                 390                 395                 400 


Leu Val Val Gly Tyr Ser His Thr Arg Gly Val Ala Ile Ser Phe Leu 
                405                 410                 415     


Val Leu Ala Val Gly Phe Ser Gly Phe Ala Ile Ser Gly Phe Asn Val 
            420                 425                 430         


Asn His Leu Asp Ile Ala Pro Arg Tyr Ala Ser Ile Leu Met Gly Ile 
        435                 440                 445             


Ser Asn Gly Val Gly Thr Leu Ser Gly Met Val Cys Pro Ile Ile Val 
    450                 455                 460                 


Gly Ala Met Thr Lys Asn Lys Ser Arg Glu Glu Trp Gln Tyr Val Phe 
465                 470                 475                 480 


Leu Ile Ala Ala Leu Val His Tyr Gly Gly Val Ile Phe Tyr Ala Ile 
                485                 490                 495     


Phe Ala Ser Gly Glu Lys Gln Pro Trp Ala Asp Pro Glu Glu Thr Ser 
            500                 505                 510         


Glu Glu Lys Cys Gly Phe Ile His Glu Asp Glu Leu Asp Glu Glu Thr 
        515                 520                 525             


Gly Asp Ile Thr Gln Asn Tyr Ile Asn Tyr Gly Thr Thr Lys Ser Tyr 
    530                 535                 540                 


Gly Ala Thr Thr Gln Ala Asn Gly Gly Trp Pro Ser Gly Trp Glu Lys 
545                 550                 555                 560 


Lys Glu Glu Phe Val Gln Gly Glu Val Gln Asp Ser His Ser Tyr Lys 
                565                 570                 575     


Asp Arg Val Asp Tyr Ser 
            580         


<210>  2650
<211>  6641
<212>  DNA
<213>  Homosapiens

<400>  2650
ctttcaaata aggtgttgat ttatgtggtc ttgagaaatc tttgttgctc tgatcttaag     60

tttcttttta taatattaga atcatagttt acctacatta cagggctttt atgaagatta    120

aatcgagcat cgtgggtagt gttttttcag cccctgtgac taagtaggtt ataaatggtc    180

ctcagtcatc atcatcataa atgattcaag gcctgaatgg cagaagaaga agaggaaaac    240

tcaagtgaaa agtgctagac atagaacaca gcttacctaa taaaacatgc tactggctaa    300

ctaagctggg gtggctttct gccccctcta cttaaattta agaaagaaaa acagaaacgt    360

ctctgcatct gccactgcat accctctcag agcacagacc aactttgccc ttccttaaaa    420

gtcccagggt ttacctacca acttttagga aataaataac cagcctcaaa gcttggcaaa    480

gagggcatca gtatcagctc tagaggtttg ctccgattta tatctcctcc tccagtaaag    540

tcttctgctc ccactcccag ccaaccccgc tcaacgccca cccctcactg cggcactgga    600

cgcgcggggg atgcggggtt gttcccagag tagccgctaa ggggagccgg acgctagacc    660

gccctcccgc gttcccatga caacgacacc ggcgggcgcg tagcctggag agcgaagtgc    720

cggctacagc aggtgtcgga ttgcagtgcg ctcgctgagg ctccggacct tggagcgtct    780

agagtctggc tactgttcct ccgcctccct ctcgggcagc tccctaagcc ggctgggacg    840

cgcagagtga aaatggtcca ccattcaggc tccattcagt cctttaaaca gcaaaaaggt    900

atgaatataa gcaagagtga gataacaaaa gaaacttcgt taaaaccgtc tcggagatcc    960

ctgccttgcc tcgcccagag ctacgcttac tcaaagagct tgagccagtc tacttccctc   1020

ttccagtcaa ccgagagtga atctcaggct cccacatcta taaccttaat ctccactgac   1080

aaagcagagc aagttaatac tgaggagaat aaaaacgact ctgtgctgag atgttcattt   1140

gctgacctca gcgatttttg tttggcccta ggaaaagata aggattacac ggatgaatca   1200

gaacacgcta cttatgaccg atctcgtctc attaatgact ttgttatcaa agataaatct   1260

gaattcaaga caaaattatc taagaatgac atgaattaca tagcatccag tggacctctg   1320

ttcaaagatg gcaaaaggag aattgattac atcttggttt atagaaagac aaatatacca   1380

tatgataaaa gaaacacatt tgaaaagaac ctcagagcag aaggcttgat gttggagaag   1440

gagccagcta ttgcaagccc cgatatcatg tttattaaaa ttcacattcc atgggacacg   1500

ctgtgcaagt atgcagagag gctgaatatc aggatgccct tcaggaaaaa atgctattac   1560

actgacggga ggagcaaatc aatgggcagg atgcaaactt attttagaag aatcaaagac   1620

tggatggccc aaaacccaat ggttcttgac aagtcagctt ttccagacct agaggagtca   1680

gactgctata ctggcccctt cagccgtgca cggattcacc acttcataat aaataataaa   1740

gacaccttct tcagcaatgc tactcgaagc agaatagtct atcacatgct ggaacgcacc   1800

aaatatgaaa atggaatatc aaaagtgggt atccgtaaac ttataaacaa tggctcatac   1860

atagcagcgt ttccaccaca tgagggagcc tacaaaagta gccagcccat taaaacccat   1920

ggacctcaga ataacagaca tctattatat gagcgctggg cacgctgggg aatgtggtat   1980

aagcatcagc ctctggattt aatcaggctg tactttggtg agaagattgg actatacttt   2040

gcttggctgg gatggtatac tggaatgttg attcctgcag caattgttgg tttgtgcgtt   2100

ttcttctatg gattatttac aatgaataat agtcaagtaa gccaagaaat ttgtaaagcc   2160

actgaagtct ttatgtgccc tctctgtgac aagaactgct ccctgcagag actcaacgac   2220

agctgtatct atgccaaggt gacatatttg ttcgataatg gagggacagt cttctttgct   2280

atttttatgg caatatgggc cacagtcttc ctggagtttt ggaaaaggag aaggagtata   2340

ctgacctata cttgggacct tatcgaatgg gaagaagagg aggaaacact tcgtccccag   2400

tttgaagcca agtattacaa gatggagatt gtaaatccca tcacgggaaa acctgaacca   2460

catcagcctt cctcagacaa agtcactcgt cttcttgttt ctgtctcagg aatattcttc   2520

atgatatcct tggtgatcac tgcagtgttt ggagttgtgg tgtaccgcct ggttgtcatg   2580

gaacagtttg catcattcaa gtggaatttc atcaaacaat actggcagtt tgcaacatct   2640

gctgctgctg tctgtatcaa tttcataatc attatgttgc tgaatcttgc ttatgaaaaa   2700

attgcttacc tcctcaccaa tttagaatat cctcgaacag aatcagagtg ggaaaacagc   2760

ttcgccctga agatgttcct cttccagttt gtcaatttaa acagttccat cttctatatc   2820

gctttctttt tgggaagatt tgtaggccac ccaggaaaat acaataaact ttttgaccgg   2880

tggagactgg aggaatgtca tcctagtggc tgtttgatag acctctgcct ccagatgggt   2940

gtcatcatgt ttttgaagca aatatggaac aacttcatgg aactaggata cccgttgatc   3000

cagaactggt ggtcacgaca taaaatcaag cggggaatac atgatgcttc catacctcag   3060

tgggaaaatg attggaatct gcagcccatg aaccttcatg gactgatgga tgagtactta   3120

gaaatggttt tgcaatttgg ttttaccacc atctttgttg cggcttttcc tctagcccct   3180

cttttggctt tgttaaacaa tatcattgaa atcaggctgg atgcatacaa atttgtcact   3240

caatggcgga ggcctttgcc agcccgagca actgacatag gtatctggct tggaattctc   3300

gaaggaatcg gtatattggc tgtgatcacc aatgcatttg taattgctat tacttctgat   3360

tacatcccac gttttgttta tgaatacaaa tatggcccct gtgcaaatca tgtagaacca   3420

agtgaaaatt gcttgaaggg atatgtcaac aatagcctat ccttctttga cctgagtgag   3480

cttggtatgg gaaaatctgg ttattgcagg tacagagact acagaggccc gccttggagt   3540

tccaaaccct atgagtttac tttacaatac tggcatatcc ttgctgctag attggccttc   3600

attattgtgt ttgagcacct tgtttttggg attaagtcat tcatcgcata cctgattcca   3660

gacgtaccaa agggtctaca tgaccgaata cgacgagaga agtacttagt tcaagaaatg   3720

atgtatgagg ctgaactgga acatttgcaa caacaacgga gaaaaagtgg tcagcctgtt   3780

caccatgaat ggccttagtt gacacctgtt acccattagg ggtgataaca ttaatgggaa   3840

gaaatgatgg caactttgaa tgctaggtga aatctaggag gaaggcatac ttggcaaacc   3900

acatgtataa tatgctactt ggaaatgtat cacagccatc tctgggattt gaaatatcca   3960

gacttgtagg gaagaaaaca atgacttgac gaccttaaaa agggttagat tgacattgca   4020

ggaagccagg atgtaattct cagaaccagt ctcagggaga tatatgcttg gagaactctg   4080

ccttccatca actgcagtgt aatgggaaag agggtggtga ggttttgaaa gacagatttc   4140

catgtaaatg tgcacaagcc aggcatggct taaaatatca tgcagtcttc actcacatac   4200

taatttgact ttggaaagta tggttgagtt cagatactta taagaaatga cttaaacaaa   4260

tccttgcctt ggctgccaga actctacatc ccttcagttt acaggttggt aggaattgcc   4320

catgtctctt gctgagatta tggatctgtg ccacagggga tttatgctgc tttacattga   4380

ctatgcagtt gaagagttgc acatcacctt tagtggtcaa accaaaaatc taagattcca   4440

aaaagaacag cattcattga aataatattc cattgcattg gctacttcaa gtctctttta   4500

cccctggcag agccagttgc agtgcaattt tttgtactaa atgccaataa agccacatac   4560

ttataaacta tgaatggcta ttcttatata gtttagaaca caactaatcc atactttatt   4620

gtggaaggct gttttatagt atatttaatt ttttctctat gatttattac aactctcacg   4680

gaatattaac ttgaaatgct gtaaatacgt tggttttcct tgtccctttg caccttgaca   4740

gtacgtagta tacattgtgg tttatgcagc tctgacacca gtttttgcta ttgtaatatg   4800

tttattcggg aaaactgagg ccagatgctc tgcaacactt acgctttttc aacaatgtgc   4860

actcttactc atgaactaat gaaaataatg catgaatata aatctatatt atttgctaaa   4920

aaaagaaaaa acatttgtgt tttagtttct tttttcatga ctgaagggag ttttatgtta   4980

ttatttcttc catagttttg ttttggttta tttttaacaa cgctctagaa acaaagtcaa   5040

attaatcaca aaagacataa ttttgctttg ttgtggaatt tctatttcaa cgtcaactct   5100

gtatctatga gtatgtctgt tccacagaca gatgaggcag gagtgatggg gcactcaaga   5160

aagttcagag gaggcataag ctatggaggt tggaaaggaa gaaagagaag agctgaagta   5220

aatgtatggt agaaattaag acgtttcttt gcaaaacaag gaaatcacac atatgcacac   5280

atacatattt atggttacta tgattgttat tatttgtcca atcaagcaaa gcaccattat   5340

ttctaacata taaaagacca gatcaaacac aatggaaata aagctactac atatatatgc   5400

cagtatttct ctagtaagat tatgtttctc ttactagaaa actattttct aaatattaac   5460

actgaaaatg ttttgttagc ttttccttct ttctctccag aagaaacatg gatagatgat   5520

agctgtttca ttgtttgttt ttgtcaagca tattcacttt cctccttgtc ctctgattct   5580

gagcaaaggg cctcagactc tgaacttccc tcaagtgccg ttgttatgtg aactcttcca   5640

ttcagattcc agagaggttc tcatgctccc cccccctcct tatttgtagc aatcgtagca   5700

actaattcca ctaagtacaa gggagttttt tacactcctc catttttata gcatctgcat   5760

tttttttttt tgttaggtac atgtatacac ctgcctgagt ataaatactc tctctaccta   5820

ataataacat caaccaacat cttttccaaa ttagggccac agaacagcaa catttgtctg   5880

acagtagtat aaagaataat gatagctcta tccttaagaa gtatttcctt tcctttttat   5940

atagtcccgt tagggtttaa aaccatattg atcaactaga aagaaaaata tgaaaagaga   6000

aaaatatttt aatttaaaaa ttgtaataca ttgatttata aaatgccttc tctgatactt   6060

ttgaaacaga tgtgaaaaac agaaaaagaa aaaattgtct gaaatgttta ttttgcaaaa   6120

cagtgcaata gaatctagtt atgccttcat cactgttgac agtaaatact gacagcccct   6180

tgcagtgtgt tagttttaga tcactctgtt ttagttgaga gaaatgtttt atatcatggt   6240

ttttatatga atacaaatta tttctcaaag atttatagca cacactattc tcaggaattc   6300

tgtattacat gaatgctgct tatatatttt catattctaa cttgtctttt caagcaaata   6360

actaatatat atgtgcatgc agtctgcctt gacaagttgt tccaagctga agagctttca   6420

ctgtacaatg tgtggaaaat caccatagat catggctgaa atagtttgta attgtctgag   6480

tctgtgcacg tacttttaga taaaatgctg ctgagtgact gcatgatgag atacaacttc   6540

tgaatgctgc acattcttcc aaaatgatcc ttagcacaat ctattgtatg atggaatgaa   6600

tagaaaactt tttcactcaa taaattatta tttgatatgg t                       6641


<210>  2651
<211>  981
<212>  PRT
<213>  Homosapiens

<400>  2651

Met Val His His Ser Gly Ser Ile Gln Ser Phe Lys Gln Gln Lys Gly 
1               5                   10                  15      


Met Asn Ile Ser Lys Ser Glu Ile Thr Lys Glu Thr Ser Leu Lys Pro 
            20                  25                  30          


Ser Arg Arg Ser Leu Pro Cys Leu Ala Gln Ser Tyr Ala Tyr Ser Lys 
        35                  40                  45              


Ser Leu Ser Gln Ser Thr Ser Leu Phe Gln Ser Thr Glu Ser Glu Ser 
    50                  55                  60                  


Gln Ala Pro Thr Ser Ile Thr Leu Ile Ser Thr Asp Lys Ala Glu Gln 
65                  70                  75                  80  


Val Asn Thr Glu Glu Asn Lys Asn Asp Ser Val Leu Arg Cys Ser Phe 
                85                  90                  95      


Ala Asp Leu Ser Asp Phe Cys Leu Ala Leu Gly Lys Asp Lys Asp Tyr 
            100                 105                 110         


Thr Asp Glu Ser Glu His Ala Thr Tyr Asp Arg Ser Arg Leu Ile Asn 
        115                 120                 125             


Asp Phe Val Ile Lys Asp Lys Ser Glu Phe Lys Thr Lys Leu Ser Lys 
    130                 135                 140                 


Asn Asp Met Asn Tyr Ile Ala Ser Ser Gly Pro Leu Phe Lys Asp Gly 
145                 150                 155                 160 


Lys Arg Arg Ile Asp Tyr Ile Leu Val Tyr Arg Lys Thr Asn Ile Pro 
                165                 170                 175     


Tyr Asp Lys Arg Asn Thr Phe Glu Lys Asn Leu Arg Ala Glu Gly Leu 
            180                 185                 190         


Met Leu Glu Lys Glu Pro Ala Ile Ala Ser Pro Asp Ile Met Phe Ile 
        195                 200                 205             


Lys Ile His Ile Pro Trp Asp Thr Leu Cys Lys Tyr Ala Glu Arg Leu 
    210                 215                 220                 


Asn Ile Arg Met Pro Phe Arg Lys Lys Cys Tyr Tyr Thr Asp Gly Arg 
225                 230                 235                 240 


Ser Lys Ser Met Gly Arg Met Gln Thr Tyr Phe Arg Arg Ile Lys Asp 
                245                 250                 255     


Trp Met Ala Gln Asn Pro Met Val Leu Asp Lys Ser Ala Phe Pro Asp 
            260                 265                 270         


Leu Glu Glu Ser Asp Cys Tyr Thr Gly Pro Phe Ser Arg Ala Arg Ile 
        275                 280                 285             


His His Phe Ile Ile Asn Asn Lys Asp Thr Phe Phe Ser Asn Ala Thr 
    290                 295                 300                 


Arg Ser Arg Ile Val Tyr His Met Leu Glu Arg Thr Lys Tyr Glu Asn 
305                 310                 315                 320 


Gly Ile Ser Lys Val Gly Ile Arg Lys Leu Ile Asn Asn Gly Ser Tyr 
                325                 330                 335     


Ile Ala Ala Phe Pro Pro His Glu Gly Ala Tyr Lys Ser Ser Gln Pro 
            340                 345                 350         


Ile Lys Thr His Gly Pro Gln Asn Asn Arg His Leu Leu Tyr Glu Arg 
        355                 360                 365             


Trp Ala Arg Trp Gly Met Trp Tyr Lys His Gln Pro Leu Asp Leu Ile 
    370                 375                 380                 


Arg Leu Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe Ala Trp Leu Gly 
385                 390                 395                 400 


Trp Tyr Thr Gly Met Leu Ile Pro Ala Ala Ile Val Gly Leu Cys Val 
                405                 410                 415     


Phe Phe Tyr Gly Leu Phe Thr Met Asn Asn Ser Gln Val Ser Gln Glu 
            420                 425                 430         


Ile Cys Lys Ala Thr Glu Val Phe Met Cys Pro Leu Cys Asp Lys Asn 
        435                 440                 445             


Cys Ser Leu Gln Arg Leu Asn Asp Ser Cys Ile Tyr Ala Lys Val Thr 
    450                 455                 460                 


Tyr Leu Phe Asp Asn Gly Gly Thr Val Phe Phe Ala Ile Phe Met Ala 
465                 470                 475                 480 


Ile Trp Ala Thr Val Phe Leu Glu Phe Trp Lys Arg Arg Arg Ser Ile 
                485                 490                 495     


Leu Thr Tyr Thr Trp Asp Leu Ile Glu Trp Glu Glu Glu Glu Glu Thr 
            500                 505                 510         


Leu Arg Pro Gln Phe Glu Ala Lys Tyr Tyr Lys Met Glu Ile Val Asn 
        515                 520                 525             


Pro Ile Thr Gly Lys Pro Glu Pro His Gln Pro Ser Ser Asp Lys Val 
    530                 535                 540                 


Thr Arg Leu Leu Val Ser Val Ser Gly Ile Phe Phe Met Ile Ser Leu 
545                 550                 555                 560 


Val Ile Thr Ala Val Phe Gly Val Val Val Tyr Arg Leu Val Val Met 
                565                 570                 575     


Glu Gln Phe Ala Ser Phe Lys Trp Asn Phe Ile Lys Gln Tyr Trp Gln 
            580                 585                 590         


Phe Ala Thr Ser Ala Ala Ala Val Cys Ile Asn Phe Ile Ile Ile Met 
        595                 600                 605             


Leu Leu Asn Leu Ala Tyr Glu Lys Ile Ala Tyr Leu Leu Thr Asn Leu 
    610                 615                 620                 


Glu Tyr Pro Arg Thr Glu Ser Glu Trp Glu Asn Ser Phe Ala Leu Lys 
625                 630                 635                 640 


Met Phe Leu Phe Gln Phe Val Asn Leu Asn Ser Ser Ile Phe Tyr Ile 
                645                 650                 655     


Ala Phe Phe Leu Gly Arg Phe Val Gly His Pro Gly Lys Tyr Asn Lys 
            660                 665                 670         


Leu Phe Asp Arg Trp Arg Leu Glu Glu Cys His Pro Ser Gly Cys Leu 
        675                 680                 685             


Ile Asp Leu Cys Leu Gln Met Gly Val Ile Met Phe Leu Lys Gln Ile 
    690                 695                 700                 


Trp Asn Asn Phe Met Glu Leu Gly Tyr Pro Leu Ile Gln Asn Trp Trp 
705                 710                 715                 720 


Ser Arg His Lys Ile Lys Arg Gly Ile His Asp Ala Ser Ile Pro Gln 
                725                 730                 735     


Trp Glu Asn Asp Trp Asn Leu Gln Pro Met Asn Leu His Gly Leu Met 
            740                 745                 750         


Asp Glu Tyr Leu Glu Met Val Leu Gln Phe Gly Phe Thr Thr Ile Phe 
        755                 760                 765             


Val Ala Ala Phe Pro Leu Ala Pro Leu Leu Ala Leu Leu Asn Asn Ile 
    770                 775                 780                 


Ile Glu Ile Arg Leu Asp Ala Tyr Lys Phe Val Thr Gln Trp Arg Arg 
785                 790                 795                 800 


Pro Leu Pro Ala Arg Ala Thr Asp Ile Gly Ile Trp Leu Gly Ile Leu 
                805                 810                 815     


Glu Gly Ile Gly Ile Leu Ala Val Ile Thr Asn Ala Phe Val Ile Ala 
            820                 825                 830         


Ile Thr Ser Asp Tyr Ile Pro Arg Phe Val Tyr Glu Tyr Lys Tyr Gly 
        835                 840                 845             


Pro Cys Ala Asn His Val Glu Pro Ser Glu Asn Cys Leu Lys Gly Tyr 
    850                 855                 860                 


Val Asn Asn Ser Leu Ser Phe Phe Asp Leu Ser Glu Leu Gly Met Gly 
865                 870                 875                 880 


Lys Ser Gly Tyr Cys Arg Tyr Arg Asp Tyr Arg Gly Pro Pro Trp Ser 
                885                 890                 895     


Ser Lys Pro Tyr Glu Phe Thr Leu Gln Tyr Trp His Ile Leu Ala Ala 
            900                 905                 910         


Arg Leu Ala Phe Ile Ile Val Phe Glu His Leu Val Phe Gly Ile Lys 
        915                 920                 925             


Ser Phe Ile Ala Tyr Leu Ile Pro Asp Val Pro Lys Gly Leu His Asp 
    930                 935                 940                 


Arg Ile Arg Arg Glu Lys Tyr Leu Val Gln Glu Met Met Tyr Glu Ala 
945                 950                 955                 960 


Glu Leu Glu His Leu Gln Gln Gln Arg Arg Lys Ser Gly Gln Pro Val 
                965                 970                 975     


His His Glu Trp Pro 
            980     


<210>  2652
<211>  2084
<212>  DNA
<213>  Homosapiens

<400>  2652
ggttcctggg cgctctgtta cacaagcaag atacagccag ccccacctaa ttttgtttcc     60

ctggcaccct cctgctcagt gcgacattgt cacacttaac ccatctgttt tctctaatgc    120

acgacagatt cctttcagac aggacaactg tgatatttca gttcctgatt gtaaatacct    180

cctaagcctg aagcttctgt tactagccat tgtgagcttc agtttcttca tctgcaaaat    240

gggcataata caatctattc ttgccacatc aagggattgt tattccttta aaaaaaaacc    300

aataccaaag aagcctacaa tgttggcctt agccaaaatt ctgttgattt caacgttgtt    360

ttattcactt ctatcgggga gccatggaaa agaaaatcaa gacataaaca caacacagaa    420

cattgcagaa gtttttaaaa caatggaaaa taaacctatt tctttggaaa gtgaagcaaa    480

cttaaactca gataaagaaa atataaccac ctcaaatctc aaggcgagtc attcccctcc    540

tttgaatcta cccaacaaca gccacggaat aacagatttc tccagtaact catcagcaga    600

gcattctttg ggcagtctaa aacccacatc taccatttcc acaagccctc ccttgatcca    660

tagctttgtt tctaaagtgc cttggaatgc acctatagca gatgaagatc ttttgcccat    720

ctcagcacat cccaatgcta cacctgctct gtcttcagaa aacttcactt ggtctttggt    780

caatgacacc gtgaaaactc ctgataacag ttccattaca gttagcatcc tctcttcaga    840

accaacttct ccatctgtga cccccttgat agtggaacca agtggatggc ttaccacaaa    900

cagtgatagc ttcactgggt ttacccctta tcaagaaaaa acaactctac agcctacctt    960

aaaattcacc aataattcaa aactctttcc aaatacgtca gatccccaaa aagaaaatag   1020

aaatacagga atagtattcg gggccatttt aggtgctatt ctgggtgtct cattgcttac   1080

tcttgtgggc tacttgttgt gtggaaaaag gaaaacggat tcattttccc atcggcgact   1140

ttatgacgac agaaatgaac cagttctgcg attagacaat gcaccggaac cttatgatgt   1200

gagttttggg aattctagct actacaatcc aactttgaat gattcagcca tgccagaaag   1260

tgaagaaaat gcacgtgatg gcattcctat ggatgacata cctccacttc gtacttctgt   1320

atagaactaa cagcaaaaag gcgttaaaca gcaagtgtca tctacatcct agccttttga   1380

caaattcatc tttcaaaagg ttacacaaaa ttactgtcac gtggattttg tcaaggagaa   1440

tcataaaagc aggagaccag tagcagaaat gtagacagga tgtatcatcc aaaggttttc   1500

tttcttacaa tttttggcca tcctgaggca tttactaagt agccttaatt tgtattttag   1560

tagtattttc ttagtagaaa atatttgtgg aatcagataa aactaaaaga tttcaccatt   1620

acagccctgc ctcataacta aataataaaa attattccac caaaaaattc taaaacaatg   1680

aagatgactc tttactgctc tgcctgaagc cctagtacca taattcaaga ttgcattttc   1740

ttaaatgaaa attgaaaggg tgctttttaa agaaaatttg acttaaagct aaaaagagga   1800

catagcccag agtttctgtt attgggaaat tgaggcaata gaaatgacag acctgtattc   1860

tagtacgtta taattttcta gatcagcaca cacatgatca gcccactgag ttatgaagct   1920

gacaatgact gcattcaacg gggccatggc aggaaagctg accctaccca ggaaagtaat   1980

agcttcttta aaagtcttca aaggttttgg gaattttaac ttgtcttaat atatcttagg   2040

cttcaattat ttgggtgcct taaaaactca atgagaatca tggt                    2084


<210>  2653
<211>  334
<212>  PRT
<213>  Homosapiens

<400>  2653

Met Leu Ala Leu Ala Lys Ile Leu Leu Ile Ser Thr Leu Phe Tyr Ser 
1               5                   10                  15      


Leu Leu Ser Gly Ser His Gly Lys Glu Asn Gln Asp Ile Asn Thr Thr 
            20                  25                  30          


Gln Asn Ile Ala Glu Val Phe Lys Thr Met Glu Asn Lys Pro Ile Ser 
        35                  40                  45              


Leu Glu Ser Glu Ala Asn Leu Asn Ser Asp Lys Glu Asn Ile Thr Thr 
    50                  55                  60                  


Ser Asn Leu Lys Ala Ser His Ser Pro Pro Leu Asn Leu Pro Asn Asn 
65                  70                  75                  80  


Ser His Gly Ile Thr Asp Phe Ser Ser Asn Ser Ser Ala Glu His Ser 
                85                  90                  95      


Leu Gly Ser Leu Lys Pro Thr Ser Thr Ile Ser Thr Ser Pro Pro Leu 
            100                 105                 110         


Ile His Ser Phe Val Ser Lys Val Pro Trp Asn Ala Pro Ile Ala Asp 
        115                 120                 125             


Glu Asp Leu Leu Pro Ile Ser Ala His Pro Asn Ala Thr Pro Ala Leu 
    130                 135                 140                 


Ser Ser Glu Asn Phe Thr Trp Ser Leu Val Asn Asp Thr Val Lys Thr 
145                 150                 155                 160 


Pro Asp Asn Ser Ser Ile Thr Val Ser Ile Leu Ser Ser Glu Pro Thr 
                165                 170                 175     


Ser Pro Ser Val Thr Pro Leu Ile Val Glu Pro Ser Gly Trp Leu Thr 
            180                 185                 190         


Thr Asn Ser Asp Ser Phe Thr Gly Phe Thr Pro Tyr Gln Glu Lys Thr 
        195                 200                 205             


Thr Leu Gln Pro Thr Leu Lys Phe Thr Asn Asn Ser Lys Leu Phe Pro 
    210                 215                 220                 


Asn Thr Ser Asp Pro Gln Lys Glu Asn Arg Asn Thr Gly Ile Val Phe 
225                 230                 235                 240 


Gly Ala Ile Leu Gly Ala Ile Leu Gly Val Ser Leu Leu Thr Leu Val 
                245                 250                 255     


Gly Tyr Leu Leu Cys Gly Lys Arg Lys Thr Asp Ser Phe Ser His Arg 
            260                 265                 270         


Arg Leu Tyr Asp Asp Arg Asn Glu Pro Val Leu Arg Leu Asp Asn Ala 
        275                 280                 285             


Pro Glu Pro Tyr Asp Val Ser Phe Gly Asn Ser Ser Tyr Tyr Asn Pro 
    290                 295                 300                 


Thr Leu Asn Asp Ser Ala Met Pro Glu Ser Glu Glu Asn Ala Arg Asp 
305                 310                 315                 320 


Gly Ile Pro Met Asp Asp Ile Pro Pro Leu Arg Thr Ser Val 
                325                 330                 


<210>  2654
<211>  1896
<212>  DNA
<213>  Homosapiens

<400>  2654
ggcttgtgtc atactttcca atatggaggt gaagaacttt gcagtttggg attatgttgt     60

atttgcagcc ctctttttca tttcctctgg aattggggtg ttctttgcca ttaaggagag    120

aaaaaaggca acttcccgag agttcctggt tgggggaagg caaatgagct ttggccctgt    180

cggcttgtct ctgacagcca gcttcatgtc agctgtcacg gtcctgggga ccccttctga    240

agtctaccgc tttggggcat ccttcctagt cttcttcatt gcttacctat ttgtcatcct    300

cttaacatca gagctctttc tccctgtgtt ctacagatct ggtatcacca gcacttatga    360

gtacttacaa ctacgattca acaaaccagt tcgctatgct gccacagtca tctacattgt    420

acagacgatt ctctacacag gagtggtggt gtatgctcct gccctggcac tcaatcaagt    480

gactgggttt gatctctggg gctctgtgtt tgcaacagga attgtttgca cattctactg    540

taccctggga ggattaaaag cagtggtgtg gacagatgca tttcagatgg ttgtcatgat    600

tgtgggcttc ttaacggttc tcattcaagg atcaacccat gctgggggat tccacaatgt    660

attagagcaa tcaacaaatg gatctcgact acatatattt gactttgatg tagatcctct    720

caggcgacac actttttgga ctatcacagt gggaggaact tttacttggc tcggaatcta    780

tggggtcaat caatcaacta ttcagcgatg catctcttgc aaaacagaaa agcatgctaa    840

gcttgccttg tattttaact tgctgggtct ctgggtcatt ctggtgtgtg ctgtcttctc    900

tggcttaatc atgtactctc actttaaaga ctgtgaccct tggacttctg gcatcatctc    960

agcaccagac cagctgatgc cgtactttgt catggagata tttgccacaa tgccaggact   1020

gccaggactt tttgtggctt gtgccttcag tggaactctg agcaccgtgg cttccagcat   1080

caatgccttg gcaacagtga cctttgagga ttttgtcaag agctgttttc ctcatctctc   1140

cgacaagctg agcacctgga tcagtaaagg cttatgtctc ttatttggcg tgatgtgtac   1200

ctctatgtct gtggctgcat ctgtcatggg aggtgttgtg caggcttccc tcagcattca   1260

cggcatgtgt ggaggaccaa tgctgggctt attctccctg ggaatcgtgt tcccttttgt   1320

gaattggaag ggtgcactag gaggtcttct tactggaatc accttgtcat tttgggtggc   1380

cattggggcc ttcatttacc ctgcaccagc ctctaagaca tggcctttgc ctctatcaac   1440

agaccaatgt atcaaatcaa atgtgacagc aacagggcct ccagtactat ccagcagacc   1500

tggaatagct gatacctggt actcgatttc ctacctttac tacagtgcag tgggctgctt   1560

aggatgcatt gttgctggag taatcatcag cctcataaca ggtcgccaaa gaggtgagga   1620

tattcaacca ctgttaatta gaccagtttg taatttattt tgcttttggt ctaagaagta   1680

caaaacacta tgctggtgtg gagttcagca tgacagtggg acagagcagg aaaaccttga   1740

gaatggcagt gcccggaaac agggggctga atctgtctta cagaacggac tcagaagaga   1800

aagcctggta catgttccag gctatgatcc taaggacaaa agctacaaca atatggcatt   1860

tgagactacc catttctaag gcaatacctg taaagc                             1896


<210>  2655
<211>  618
<212>  PRT
<213>  Homosapiens

<400>  2655

Met Glu Val Lys Asn Phe Ala Val Trp Asp Tyr Val Val Phe Ala Ala 
1               5                   10                  15      


Leu Phe Phe Ile Ser Ser Gly Ile Gly Val Phe Phe Ala Ile Lys Glu 
            20                  25                  30          


Arg Lys Lys Ala Thr Ser Arg Glu Phe Leu Val Gly Gly Arg Gln Met 
        35                  40                  45              


Ser Phe Gly Pro Val Gly Leu Ser Leu Thr Ala Ser Phe Met Ser Ala 
    50                  55                  60                  


Val Thr Val Leu Gly Thr Pro Ser Glu Val Tyr Arg Phe Gly Ala Ser 
65                  70                  75                  80  


Phe Leu Val Phe Phe Ile Ala Tyr Leu Phe Val Ile Leu Leu Thr Ser 
                85                  90                  95      


Glu Leu Phe Leu Pro Val Phe Tyr Arg Ser Gly Ile Thr Ser Thr Tyr 
            100                 105                 110         


Glu Tyr Leu Gln Leu Arg Phe Asn Lys Pro Val Arg Tyr Ala Ala Thr 
        115                 120                 125             


Val Ile Tyr Ile Val Gln Thr Ile Leu Tyr Thr Gly Val Val Val Tyr 
    130                 135                 140                 


Ala Pro Ala Leu Ala Leu Asn Gln Val Thr Gly Phe Asp Leu Trp Gly 
145                 150                 155                 160 


Ser Val Phe Ala Thr Gly Ile Val Cys Thr Phe Tyr Cys Thr Leu Gly 
                165                 170                 175     


Gly Leu Lys Ala Val Val Trp Thr Asp Ala Phe Gln Met Val Val Met 
            180                 185                 190         


Ile Val Gly Phe Leu Thr Val Leu Ile Gln Gly Ser Thr His Ala Gly 
        195                 200                 205             


Gly Phe His Asn Val Leu Glu Gln Ser Thr Asn Gly Ser Arg Leu His 
    210                 215                 220                 


Ile Phe Asp Phe Asp Val Asp Pro Leu Arg Arg His Thr Phe Trp Thr 
225                 230                 235                 240 


Ile Thr Val Gly Gly Thr Phe Thr Trp Leu Gly Ile Tyr Gly Val Asn 
                245                 250                 255     


Gln Ser Thr Ile Gln Arg Cys Ile Ser Cys Lys Thr Glu Lys His Ala 
            260                 265                 270         


Lys Leu Ala Leu Tyr Phe Asn Leu Leu Gly Leu Trp Val Ile Leu Val 
        275                 280                 285             


Cys Ala Val Phe Ser Gly Leu Ile Met Tyr Ser His Phe Lys Asp Cys 
    290                 295                 300                 


Asp Pro Trp Thr Ser Gly Ile Ile Ser Ala Pro Asp Gln Leu Met Pro 
305                 310                 315                 320 


Tyr Phe Val Met Glu Ile Phe Ala Thr Met Pro Gly Leu Pro Gly Leu 
                325                 330                 335     


Phe Val Ala Cys Ala Phe Ser Gly Thr Leu Ser Thr Val Ala Ser Ser 
            340                 345                 350         


Ile Asn Ala Leu Ala Thr Val Thr Phe Glu Asp Phe Val Lys Ser Cys 
        355                 360                 365             


Phe Pro His Leu Ser Asp Lys Leu Ser Thr Trp Ile Ser Lys Gly Leu 
    370                 375                 380                 


Cys Leu Leu Phe Gly Val Met Cys Thr Ser Met Ser Val Ala Ala Ser 
385                 390                 395                 400 


Val Met Gly Gly Val Val Gln Ala Ser Leu Ser Ile His Gly Met Cys 
                405                 410                 415     


Gly Gly Pro Met Leu Gly Leu Phe Ser Leu Gly Ile Val Phe Pro Phe 
            420                 425                 430         


Val Asn Trp Lys Gly Ala Leu Gly Gly Leu Leu Thr Gly Ile Thr Leu 
        435                 440                 445             


Ser Phe Trp Val Ala Ile Gly Ala Phe Ile Tyr Pro Ala Pro Ala Ser 
    450                 455                 460                 


Lys Thr Trp Pro Leu Pro Leu Ser Thr Asp Gln Cys Ile Lys Ser Asn 
465                 470                 475                 480 


Val Thr Ala Thr Gly Pro Pro Val Leu Ser Ser Arg Pro Gly Ile Ala 
                485                 490                 495     


Asp Thr Trp Tyr Ser Ile Ser Tyr Leu Tyr Tyr Ser Ala Val Gly Cys 
            500                 505                 510         


Leu Gly Cys Ile Val Ala Gly Val Ile Ile Ser Leu Ile Thr Gly Arg 
        515                 520                 525             


Gln Arg Gly Glu Asp Ile Gln Pro Leu Leu Ile Arg Pro Val Cys Asn 
    530                 535                 540                 


Leu Phe Cys Phe Trp Ser Lys Lys Tyr Lys Thr Leu Cys Trp Cys Gly 
545                 550                 555                 560 


Val Gln His Asp Ser Gly Thr Glu Gln Glu Asn Leu Glu Asn Gly Ser 
                565                 570                 575     


Ala Arg Lys Gln Gly Ala Glu Ser Val Leu Gln Asn Gly Leu Arg Arg 
            580                 585                 590         


Glu Ser Leu Val His Val Pro Gly Tyr Asp Pro Lys Asp Lys Ser Tyr 
        595                 600                 605             


Asn Asn Met Ala Phe Glu Thr Thr His Phe 
    610                 615             


<210>  2656
<211>  2315
<212>  DNA
<213>  Homosapiens

<400>  2656
ctttaggaga ggagcagaca gctcttagct agggtcagat ttcaaattct catctcttgg     60

tgccaatacc accaccagat tcttctttga agtcaacttt tgagatcttc actaagtaca    120

cgttggtgtc tgaagattca cacgagtgcc tctggtaatc attttcttca gggaatcaca    180

gtctctcctc tcagcaaagc atccactgta ctgaactttg cttttggaaa catcttcttc    240

ctgagacctc gttgaaagaa actctctggt gtcatacttt ccaatatgga ggtgaagaac    300

tttgcagttt gggattatgt tgtatttgca gccctctttt tcatttcctc tggaattggg    360

gtgttctttg ccattaagga gagaaaaaag gcaacttccc gagagttcct ggttggggga    420

aggcaaatga gctttggccc tgtcggcttg tctctgacag ccagcttcat gtcagctgtc    480

acggtcctgg ggaccccttc tgaagtctac cgctttgggg catccttcct agtcttcttc    540

attgcttacc tatttgtcat cctcttaaca tcagagctct ttctccctgt gttctacaga    600

tctggtatca ccagcactta tgagtactta caactacgat tcaacaaacc agttcgctat    660

gctgccacag tcatctacat tgtacagacg attctctaca caggagtggt ggtgtatgct    720

cctgccctgg cactcaatca agtgactggg tttgatctct ggggctctgt gtttgcaaca    780

ggaattgttt gcacattcta ctgtaccctg ggaggattaa aagcagtggt gtggacagat    840

gcatttcaga tggttgtcat gattgtgggc ttcttaacgg ttctcattca aggatcaact    900

catgctgggg gattccacaa tgtattagag caatcaacaa atggatctcg actacatata    960

tttgactttg atgtagatcc tctcaggcga cacacttttt ggactatcac agtgggagga   1020

acttttactt ggctcggaat ctatggggtc aatcaatcaa ctattcagcg atgcatctct   1080

tgcaaaacag aaaagcatgc taagcttgcc ttgtatttta acttgctggg tctctggatc   1140

attctggtgt gtgctgtctt ctctggctta atcatgtact ctcactttaa agactgtgac   1200

ccttggactt ctggcatcat ctcagcacca gaccagctga tgccgtactt tgtcatggag   1260

atatttgcca caatgccagg actgccagga ctttttgtgg cttgtgcctt cagtggaact   1320

ctgagcaccg tggcttccag catcaatgcc ttggcaacag tgacctttga ggattttgtc   1380

aagagctgtt ttcctcatct ctccgacaag ctgagcacct ggatcagtaa aggcttatgt   1440

aggtacagct ggtggacttt ctattccata tcatgaaatg tacatgtggt agatgtcaaa   1500

atcctgcatg tgctattcag gacacactta taaacacaaa tgcactgtga gatatgtgaa   1560

gaatcccaca catagattct tacacttcca aagatccagc agggtatcag gaaagaatga   1620

ctagctagtt taccttaact gcctttattt tcagatactc ttctatactt accctacact   1680

ctagacgagg cttatccaac ccacggcctg tgggccgcat gcggcccagg atggctttga   1740

atgcagccca acacaaattc gtaaactttc ttaaaacatt ctggaatttt tttgtaattt   1800

tttaaatctt atcagctatc attagtgttt gtgtatttta tgtgtactcc aaggcaactc   1860

cttctttcaa cgtggcccag ggaggccaaa agattggaca cccctgcaaa ctaatcacat   1920

caatctctct tgattacact gtgtgatggt catattagtc tctctacatg ggaagatgtt   1980

gtgcttacta tggccagtca ctttgacaaa gaaaagccaa attcttttct aaagaattgt   2040

tccttattac caaactccca gtaaccccct caaagaataa ttgccccttg cttaatcatg   2100

caattgcata ttatgtttat actcacttca gcacttatca gagataattg cagtttcaca   2160

aggtttactt tttaaagtat aaacaaatta tgtatttact tactaataga aaatataggt   2220

aatttgggga aatttatgta cattgttaaa taaaattata tctatctaaa aaaaaaaaaa   2280

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                              2315


<210>  2657
<211>  396
<212>  PRT
<213>  Homosapiens

<400>  2657

Met Glu Val Lys Asn Phe Ala Val Trp Asp Tyr Val Val Phe Ala Ala 
1               5                   10                  15      


Leu Phe Phe Ile Ser Ser Gly Ile Gly Val Phe Phe Ala Ile Lys Glu 
            20                  25                  30          


Arg Lys Lys Ala Thr Ser Arg Glu Phe Leu Val Gly Gly Arg Gln Met 
        35                  40                  45              


Ser Phe Gly Pro Val Gly Leu Ser Leu Thr Ala Ser Phe Met Ser Ala 
    50                  55                  60                  


Val Thr Val Leu Gly Thr Pro Ser Glu Val Tyr Arg Phe Gly Ala Ser 
65                  70                  75                  80  


Phe Leu Val Phe Phe Ile Ala Tyr Leu Phe Val Ile Leu Leu Thr Ser 
                85                  90                  95      


Glu Leu Phe Leu Pro Val Phe Tyr Arg Ser Gly Ile Thr Ser Thr Tyr 
            100                 105                 110         


Glu Tyr Leu Gln Leu Arg Phe Asn Lys Pro Val Arg Tyr Ala Ala Thr 
        115                 120                 125             


Val Ile Tyr Ile Val Gln Thr Ile Leu Tyr Thr Gly Val Val Val Tyr 
    130                 135                 140                 


Ala Pro Ala Leu Ala Leu Asn Gln Val Thr Gly Phe Asp Leu Trp Gly 
145                 150                 155                 160 


Ser Val Phe Ala Thr Gly Ile Val Cys Thr Phe Tyr Cys Thr Leu Gly 
                165                 170                 175     


Gly Leu Lys Ala Val Val Trp Thr Asp Ala Phe Gln Met Val Val Met 
            180                 185                 190         


Ile Val Gly Phe Leu Thr Val Leu Ile Gln Gly Ser Thr His Ala Gly 
        195                 200                 205             


Gly Phe His Asn Val Leu Glu Gln Ser Thr Asn Gly Ser Arg Leu His 
    210                 215                 220                 


Ile Phe Asp Phe Asp Val Asp Pro Leu Arg Arg His Thr Phe Trp Thr 
225                 230                 235                 240 


Ile Thr Val Gly Gly Thr Phe Thr Trp Leu Gly Ile Tyr Gly Val Asn 
                245                 250                 255     


Gln Ser Thr Ile Gln Arg Cys Ile Ser Cys Lys Thr Glu Lys His Ala 
            260                 265                 270         


Lys Leu Ala Leu Tyr Phe Asn Leu Leu Gly Leu Trp Ile Ile Leu Val 
        275                 280                 285             


Cys Ala Val Phe Ser Gly Leu Ile Met Tyr Ser His Phe Lys Asp Cys 
    290                 295                 300                 


Asp Pro Trp Thr Ser Gly Ile Ile Ser Ala Pro Asp Gln Leu Met Pro 
305                 310                 315                 320 


Tyr Phe Val Met Glu Ile Phe Ala Thr Met Pro Gly Leu Pro Gly Leu 
                325                 330                 335     


Phe Val Ala Cys Ala Phe Ser Gly Thr Leu Ser Thr Val Ala Ser Ser 
            340                 345                 350         


Ile Asn Ala Leu Ala Thr Val Thr Phe Glu Asp Phe Val Lys Ser Cys 
        355                 360                 365             


Phe Pro His Leu Ser Asp Lys Leu Ser Thr Trp Ile Ser Lys Gly Leu 
    370                 375                 380                 


Cys Arg Tyr Ser Trp Trp Thr Phe Tyr Ser Ile Ser 
385                 390                 395     


<210>  2658
<211>  3218
<212>  DNA
<213>  Homosapiens

<400>  2658
aattaatttt gattacattt aaaattctat atggcaaaaa taccataatt aaagataaaa     60

ggcaaagaac aaattgggaa aaatattttt caacatatat aaccaagggc taatttctct    120

aacacctaaa aagttcttat aaatcaataa aaagaaaacc aacatctcaa tggaaaaaga    180

acaaagctca taaagagttc acagaaaaag gatatacaaa tggctttaaa catgtgaaag    240

aatgttcaac ttcactcaca ataagaaaaa atacaaatta tgagttgctt cagcatcctg    300

gtgttgctgt gccgtgggtc ctgtgcggtc acttagccaa gatgcctgag gaaacccaga    360

cccaagacca accgatggag gaggaggagg ttgagacatt cgcctttcag gcagaaattg    420

cccagttgat gtcattgatc atcaatactt tctactcgaa caaagagatc tttctgagag    480

agctcatttc aaattcatca gatgcattgg acaaaatctg gtatgaaagc ttgacagatc    540

ccagtaaatt agactctggg aaagagctgc atattaacct tataccaaac aaacaagatc    600

aaactctcac tattgtggat actggaattg gaatgaccaa ggctgacttg atcaataacc    660

ttggtactat cgccaagtct gggaccaaag cgttcatgga agctttgcag gctggtgcag    720

atatctctat gattggccag ttcggtgtta gtttttattc tgcttatttg gttgctgaga    780

aagtaactgt gatcaccaaa cataatgatg atgagcagta cgcctgggag tcctcagcag    840

ggggatcatt cacagtgagg acagacacag gtgaacgtat gggtcgtgga acaaaggtta    900

tcctacacct gaaagaagac caaactgagt acttggagga acaaagaata aaggagattg    960

tgaagaaaca ttctcagctt attggatatc ccattactct ttttgtggag aaggaatgtg   1020

ataaagaagt cagcgacgat gagactgaag aaaaggaaga caaagaagaa gaaaaagaaa   1080

aagaagagaa agagtccaaa gacaaacctg aaattgaaga tgttggttct gatgaggaag   1140

aagaaaagaa ggatggtgac aagaagaaga agaagactaa ggaaaagtac atcgaccaag   1200

aagaactcaa caaaacaaag cccatctgga ccagaaatcc cgacgatatt actaatgagg   1260

agtacggaga attctgcaag aacttgacca atgactggga agatcacttg gcagtgaagc   1320

atttttcagt tgaaggacag ttggaattca gagcccttct atttgtccca tgacgtgctc   1380

cttttgacct gtttgaaaac agaaagaaaa agaacaacat caaattgtat gtacgcagag   1440

atttcatcat ggataactgt gaggagctaa tccctgaata tctgaacttc attagagggg   1500

tggtagactc ggaggatctc cctctaaaca tttcccgtga gatgttgcaa caaagtaaaa   1560

ttttgaaagt tatcaggaaa aatttggtca aaaaatgctt agaactcttt acagaactgg   1620

cggaagataa agagaactgc aagaaattct atgagcagtt ctctaaaaac ataaagcttg   1680

gaatacaaga agactctcaa aatcggaaga agctttcaga gctgttaagg tactacacgt   1740

ctgcctctgg tgatgagatg gtttctctca aggactactg caccagaatg aaggaaaaac   1800

agaaacatat ctattatatc acaggtgaga ccaaggacca ggtagctaac tcagcctttg   1860

tggaacgtct tgggaaacat ggcttagaag tgatctatat gattgagccc attgatgagt   1920

actgtgtcca acagctgaag gaatttgagg ggaagacttt agtgccagtc accaaagaag   1980

gcctggaact tccagaggat gaagaaaaga aaaagaaata ggaagagaaa aaacaatgtt   2040

tgagaacctc tgcaaaacca tgaaagacat attggagaaa aaagttgaaa aggtggttgt   2100

gtcaaaccga ttggtgacgt ctccatgctg tattgtcaca agcacatatg gctggacaga   2160

aaacatggag agaatcatga aagctcaagc cctaagagac aactcaacaa tgggttatat   2220

ggcagccaag aaacacctgg agataaatcc tgatgattcc attattgaga ccttaaggca   2280

aaaggcagag gctgataaga atgacaagtc tgtgaaggat ctgctcatct tgctttacga   2340

aactgcactc ctgtcttctg gcttcagtct ggaagatccc cagacacatg ctaacaggac   2400

ctacaggatg atcaaacttg gtctgggtat tgatgaagat gatcctgctg ctgatgatac   2460

cagtgctgct gtaactgaag aaatgccgcc cctcgaagga gatgacgaca catcatgcat   2520

ggaagaagta gactaacctc tggctaaggg atgacttaac tgttcaatac tctacaattc   2580

ctccgataat atatattcaa ggatgttttt ctttattttt gttaatatta aaaagtctgt   2640

acggcatgac aacaactact ttaaggggaa gataagattt ctgtctacta agtgatgctg   2700

tgatacctta ggcactaaag cagagctagt aatgcttttt gagtttcacg tcggtttatt   2760

ttcacagatt ggggtaacgt gcgttgtaag atgtatgtaa catgatgtta actttgtggt   2820

ctaaagtgtt tagctgtcaa gccggattcc taagtagacc aaatcttgtt atcgaagtgt   2880

tcctgagcta taccttgatg tttagaaaag tatttgttac atcttgtagg atctactttt   2940

tgaacttttc atcccctata gttgacaatt ctgcatgtac tagtcctcta gaaataggtt   3000

aaactgaagc aacttgatgg aaggatctct ccacagggct tgttttccaa agaaaagtat   3060

tgtttggagg agcaaagtta taagcctacc taagcatatc ataaagctgt ttaaaaataa   3120

ctcagacccg gtcttgtgga tggaaatgta gtgctcgagt cacattcttc ttatagttgt   3180

aacaaataca gatgagttaa aagaaaaaaa aagaaaaa                           3218


<210>  2659
<211>  343
<212>  PRT
<213>  Homosapiens

<400>  2659

Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu 
1               5                   10                  15      


Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu 
            20                  25                  30          


Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu 
        35                  40                  45              


Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Trp Tyr Glu Ser Leu 
    50                  55                  60                  


Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu 
65                  70                  75                  80  


Ile Pro Asn Lys Gln Asp Gln Thr Leu Thr Ile Val Asp Thr Gly Ile 
                85                  90                  95      


Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys 
            100                 105                 110         


Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile 
        115                 120                 125             


Ser Met Ile Gly Gln Phe Gly Val Ser Phe Tyr Ser Ala Tyr Leu Val 
    130                 135                 140                 


Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr 
145                 150                 155                 160 


Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr 
                165                 170                 175     


Gly Glu Arg Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu 
            180                 185                 190         


Asp Gln Thr Glu Tyr Leu Glu Glu Gln Arg Ile Lys Glu Ile Val Lys 
        195                 200                 205             


Lys His Ser Gln Leu Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys 
    210                 215                 220                 


Glu Cys Asp Lys Glu Val Ser Asp Asp Glu Thr Glu Glu Lys Glu Asp 
225                 230                 235                 240 


Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Lys Asp Lys Pro 
                245                 250                 255     


Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly 
            260                 265                 270         


Asp Lys Lys Lys Lys Lys Thr Lys Glu Lys Tyr Ile Asp Gln Glu Glu 
        275                 280                 285             


Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile Thr 
    290                 295                 300                 


Asn Glu Glu Tyr Gly Glu Phe Cys Lys Asn Leu Thr Asn Asp Trp Glu 
305                 310                 315                 320 


Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu Phe 
                325                 330                 335     


Arg Ala Leu Leu Phe Val Pro 
            340             


<210>  2660
<211>  3379
<212>  DNA
<213>  Homosapiens

<400>  2660
ctggcctggg cctgaagtga gtgagaggca catgaagaga agtattcaag tatttataca     60

gataggaatc aagataatca acaatgtctg tcactgagga agacctgtgc caccatatga    120

aagtagtagt tcgtgtacgt ccggaaaaca ctaaagaaaa agcagctgga tttcataaag    180

tggttcatgt tgtggataaa catatcctag tttttgatcc caaacaagaa gaagtcagtt    240

ttttccatgg aaagaaaact acaaatcaaa atgttataaa gaaacaaaat aaggatctta    300

aatttgtatt tgatgctgtt tttgatgaaa cgtcaactca gtcagaagtt tttgaacaca    360

ctactaagcc aattcttcgt agttttttga atggatataa ttgcacagta cttgcctatg    420

gtgccactgg tgctgggaag acccacacta tgctaggatc agctgatgaa cctggagtga    480

tgtatctaac aatgttacac ctttacaaat gcatggatga gattaaagaa gagaaaatat    540

gtagtactgc agtttcatat ctggaggtat ataatgaaca gattcgtgat ctcttagtaa    600

attcagggcc acttgctgtc cgggaagata cccaaaaagg ggtggtcgtt catggactta    660

ctttacacca gcccaaatcc tcagaagaaa ttttacattt attggataat ggaaacaaaa    720

acaggacaca acatcccact gatatgaatg ccacatcttc tcgttctcat gctgttttcc    780

aaatttactt gcgacaacaa gacaaaacag caagtatcaa tcaaaatgtc cgtattgcca    840

agatgtcact cattgacctg gcaggatctg agcgagcaag tacttccggt gctaagggga    900

cccgatttgt agaaggcaca aatattaata gatcactttt agctcttggg aatgtcatca    960

atgccttagc agattcaaag agaaagaatc agcatatccc ttacagaaat agtaagctta   1020

ctcgcttgtt aaaggattct cttggaggaa actgtcaaac tataatgata gctgctgtta   1080

gtccttcctc tgtattctac gatgacacat ataacactct taagtatgct aaccgggcaa   1140

aggacattaa atcttctttg aagagcaatg ttcttaatgt caataatcat ataactcaat   1200

atgtaaagat ctgtaatgag cagaaggcag agattttatt gttaaaagaa aaactaaaag   1260

cctatgaaga acagaaagcc ttcactaatg aaaatgacca agcaaagtta atgatttcaa   1320

accctcagga aaaagaaatc gaaaggtttc aagaaatcct gaactgcttg ttccagaatc   1380

gagaagaaat tagacaagaa tatctgaagt tggaaatgtt acttaaagaa aatgaactta   1440

aatcattcta ccaacaacag tgccataaac aaatagaaat gatgtgttct gaagacaaag   1500

tagaaaaggc cactggaaaa cgagatcata gacttgcaat gttgaaaact cgtcgctcct   1560

acctggagaa aaggagggag gaggaattga agcaatttga tgagaatact aattggctcc   1620

atcgtgtcga aaaagaaatg ggactcttaa gtcaaaacgg tcatattcca aaggaactca   1680

agaaagatct tcattgtcac catttgcacc tccagaacaa agatttgaaa gcacaaatta   1740

gacatatgat ggatctagct tgtcttcagg aacagcaaca caggcagact gaagcagtat   1800

tgaatgcttt acttccaacc ctaagaaaac aatattgcac attaaaagaa gccggcctgt   1860

caaatgctgc ttttgaatct gacttcaaag agatcgaaca tttggtagag aggaaaaaag   1920

tggtagtttg ggctgaccaa actggcgaac aaccaaagca aaacgatcta cccgggattt   1980

ctgttcttat gaccttttca caacttggac cagttcagcc tattccttgt tgctcatctt   2040

caggtggaac taatctggtt aagattccta cagaaaaaag aactcggaga aaactaatgc   2100

catctccctt gaaaggacag catactctaa agtctccacc atctcaaagt gtgcagctca   2160

atgattctct tagcaaagaa cttcagccta ttgtatatac accagaagac tgtagaaaag   2220

cttttcaaaa tccgtctaca gtaaccttaa tgaaaccatc atcatttact acaagttttc   2280

aggctatcag ctcaaacata aacagtgata attgtctgaa aatgttgtgt gaagtagcta   2340

tccctcataa tagaagaaaa gaatgtggac aggaggactt ggactctaca tttactatat   2400

gtgaagacat caagagctcg aagtgtaaat tacccgaaca agaatcacta ccaaatgata   2460

acaaagacat tttacaacgg cttgatcctt cttcattctc aactaagcat tctatgcctg   2520

taccaagcat ggtgccatcc tacatggcaa tgactactgc tgccaaaagg aaacggaaat   2580

taacaagttc tacatcaaac agttcgttaa ctgcagacgt aaattctgga tttgccaaac   2640

gtgttcgaca agataattca agtgagaagc acttacaaga aaacaaacca acaatggaac   2700

ataaaagaaa catctgtaaa ataaatccaa gcatggttag aaaatttgga agaaatattt   2760

caaaaggaaa tctaagataa atcacttcaa aaccaagcaa aatgaagttg atcaaatctg   2820

cttttcaaag tttatccaat accctttcaa aaatatattt aaaatctttg aaagaagacc   2880

catcttaaag ctaagtttac ccaagtactt tcagcaagca gaaaaatgaa actctttgtt   2940

ttcttctttt gtgttctaaa aaaataaaat ttcaaaagaa aaggttgtct tttaagtttt   3000

ttaaatattt gttgcctttt aaaatccctg agtgtaagtt accatggtgg cagcttagtt   3060

ttactatgcc acaacaagtt gactaggaca ttttagtaaa tggtagtgag ttaaattatc   3120

tttattattt tttaaaaata agaatttaga agtggtaaaa ttatggccca agatgtattt   3180

ggttctctat tatgttttga tacattattt taatcatata tatgactttc cttttcaaaa   3240

atactttaat gtacaagtgt aaatatatgt gcccataaaa tcattgtaaa tattatttag   3300

tcatcacaaa taaaatattg tcccttgcta cttgatatat taaagatgta gattttaaag   3360

tgaaaaaaaa aaaaaaaaa                                                3379


<210>  2661
<211>  898
<212>  PRT
<213>  Homosapiens

<400>  2661

Met Ser Val Thr Glu Glu Asp Leu Cys His His Met Lys Val Val Val 
1               5                   10                  15      


Arg Val Arg Pro Glu Asn Thr Lys Glu Lys Ala Ala Gly Phe His Lys 
            20                  25                  30          


Val Val His Val Val Asp Lys His Ile Leu Val Phe Asp Pro Lys Gln 
        35                  40                  45              


Glu Glu Val Ser Phe Phe His Gly Lys Lys Thr Thr Asn Gln Asn Val 
    50                  55                  60                  


Ile Lys Lys Gln Asn Lys Asp Leu Lys Phe Val Phe Asp Ala Val Phe 
65                  70                  75                  80  


Asp Glu Thr Ser Thr Gln Ser Glu Val Phe Glu His Thr Thr Lys Pro 
                85                  90                  95      


Ile Leu Arg Ser Phe Leu Asn Gly Tyr Asn Cys Thr Val Leu Ala Tyr 
            100                 105                 110         


Gly Ala Thr Gly Ala Gly Lys Thr His Thr Met Leu Gly Ser Ala Asp 
        115                 120                 125             


Glu Pro Gly Val Met Tyr Leu Thr Met Leu His Leu Tyr Lys Cys Met 
    130                 135                 140                 


Asp Glu Ile Lys Glu Glu Lys Ile Cys Ser Thr Ala Val Ser Tyr Leu 
145                 150                 155                 160 


Glu Val Tyr Asn Glu Gln Ile Arg Asp Leu Leu Val Asn Ser Gly Pro 
                165                 170                 175     


Leu Ala Val Arg Glu Asp Thr Gln Lys Gly Val Val Val His Gly Leu 
            180                 185                 190         


Thr Leu His Gln Pro Lys Ser Ser Glu Glu Ile Leu His Leu Leu Asp 
        195                 200                 205             


Asn Gly Asn Lys Asn Arg Thr Gln His Pro Thr Asp Met Asn Ala Thr 
    210                 215                 220                 


Ser Ser Arg Ser His Ala Val Phe Gln Ile Tyr Leu Arg Gln Gln Asp 
225                 230                 235                 240 


Lys Thr Ala Ser Ile Asn Gln Asn Val Arg Ile Ala Lys Met Ser Leu 
                245                 250                 255     


Ile Asp Leu Ala Gly Ser Glu Arg Ala Ser Thr Ser Gly Ala Lys Gly 
            260                 265                 270         


Thr Arg Phe Val Glu Gly Thr Asn Ile Asn Arg Ser Leu Leu Ala Leu 
        275                 280                 285             


Gly Asn Val Ile Asn Ala Leu Ala Asp Ser Lys Arg Lys Asn Gln His 
    290                 295                 300                 


Ile Pro Tyr Arg Asn Ser Lys Leu Thr Arg Leu Leu Lys Asp Ser Leu 
305                 310                 315                 320 


Gly Gly Asn Cys Gln Thr Ile Met Ile Ala Ala Val Ser Pro Ser Ser 
                325                 330                 335     


Val Phe Tyr Asp Asp Thr Tyr Asn Thr Leu Lys Tyr Ala Asn Arg Ala 
            340                 345                 350         


Lys Asp Ile Lys Ser Ser Leu Lys Ser Asn Val Leu Asn Val Asn Asn 
        355                 360                 365             


His Ile Thr Gln Tyr Val Lys Ile Cys Asn Glu Gln Lys Ala Glu Ile 
    370                 375                 380                 


Leu Leu Leu Lys Glu Lys Leu Lys Ala Tyr Glu Glu Gln Lys Ala Phe 
385                 390                 395                 400 


Thr Asn Glu Asn Asp Gln Ala Lys Leu Met Ile Ser Asn Pro Gln Glu 
                405                 410                 415     


Lys Glu Ile Glu Arg Phe Gln Glu Ile Leu Asn Cys Leu Phe Gln Asn 
            420                 425                 430         


Arg Glu Glu Ile Arg Gln Glu Tyr Leu Lys Leu Glu Met Leu Leu Lys 
        435                 440                 445             


Glu Asn Glu Leu Lys Ser Phe Tyr Gln Gln Gln Cys His Lys Gln Ile 
    450                 455                 460                 


Glu Met Met Cys Ser Glu Asp Lys Val Glu Lys Ala Thr Gly Lys Arg 
465                 470                 475                 480 


Asp His Arg Leu Ala Met Leu Lys Thr Arg Arg Ser Tyr Leu Glu Lys 
                485                 490                 495     


Arg Arg Glu Glu Glu Leu Lys Gln Phe Asp Glu Asn Thr Asn Trp Leu 
            500                 505                 510         


His Arg Val Glu Lys Glu Met Gly Leu Leu Ser Gln Asn Gly His Ile 
        515                 520                 525             


Pro Lys Glu Leu Lys Lys Asp Leu His Cys His His Leu His Leu Gln 
    530                 535                 540                 


Asn Lys Asp Leu Lys Ala Gln Ile Arg His Met Met Asp Leu Ala Cys 
545                 550                 555                 560 


Leu Gln Glu Gln Gln His Arg Gln Thr Glu Ala Val Leu Asn Ala Leu 
                565                 570                 575     


Leu Pro Thr Leu Arg Lys Gln Tyr Cys Thr Leu Lys Glu Ala Gly Leu 
            580                 585                 590         


Ser Asn Ala Ala Phe Glu Ser Asp Phe Lys Glu Ile Glu His Leu Val 
        595                 600                 605             


Glu Arg Lys Lys Val Val Val Trp Ala Asp Gln Thr Gly Glu Gln Pro 
    610                 615                 620                 


Lys Gln Asn Asp Leu Pro Gly Ile Ser Val Leu Met Thr Phe Ser Gln 
625                 630                 635                 640 


Leu Gly Pro Val Gln Pro Ile Pro Cys Cys Ser Ser Ser Gly Gly Thr 
                645                 650                 655     


Asn Leu Val Lys Ile Pro Thr Glu Lys Arg Thr Arg Arg Lys Leu Met 
            660                 665                 670         


Pro Ser Pro Leu Lys Gly Gln His Thr Leu Lys Ser Pro Pro Ser Gln 
        675                 680                 685             


Ser Val Gln Leu Asn Asp Ser Leu Ser Lys Glu Leu Gln Pro Ile Val 
    690                 695                 700                 


Tyr Thr Pro Glu Asp Cys Arg Lys Ala Phe Gln Asn Pro Ser Thr Val 
705                 710                 715                 720 


Thr Leu Met Lys Pro Ser Ser Phe Thr Thr Ser Phe Gln Ala Ile Ser 
                725                 730                 735     


Ser Asn Ile Asn Ser Asp Asn Cys Leu Lys Met Leu Cys Glu Val Ala 
            740                 745                 750         


Ile Pro His Asn Arg Arg Lys Glu Cys Gly Gln Glu Asp Leu Asp Ser 
        755                 760                 765             


Thr Phe Thr Ile Cys Glu Asp Ile Lys Ser Ser Lys Cys Lys Leu Pro 
    770                 775                 780                 


Glu Gln Glu Ser Leu Pro Asn Asp Asn Lys Asp Ile Leu Gln Arg Leu 
785                 790                 795                 800 


Asp Pro Ser Ser Phe Ser Thr Lys His Ser Met Pro Val Pro Ser Met 
                805                 810                 815     


Val Pro Ser Tyr Met Ala Met Thr Thr Ala Ala Lys Arg Lys Arg Lys 
            820                 825                 830         


Leu Thr Ser Ser Thr Ser Asn Ser Ser Leu Thr Ala Asp Val Asn Ser 
        835                 840                 845             


Gly Phe Ala Lys Arg Val Arg Gln Asp Asn Ser Ser Glu Lys His Leu 
    850                 855                 860                 


Gln Glu Asn Lys Pro Thr Met Glu His Lys Arg Asn Ile Cys Lys Ile 
865                 870                 875                 880 


Asn Pro Ser Met Val Arg Lys Phe Gly Arg Asn Ile Ser Lys Gly Asn 
                885                 890                 895     


Leu Arg 
        


<210>  2662
<211>  3959
<212>  DNA
<213>  Homosapiens

<400>  2662
ctagacgcgc ggcgcattca ggttctcctg gaccgtagtg gtagtcgctg gcccgagtta     60

gaggccagct gagaagtctt cgtgcttcag atttgtttac ctacaaaatg cttcggtatc    120

catatttttg tagaatgtat aaagaatgcc tttcatgttg gttggaatct ggcataccta    180

atttaggtgt ctggccaaaa agaatacata ctacagcaga aaaatataga gaatatgaag    240

cccgggagca aacagatcaa actcaagccc aggagttaca cagatctcaa gatagagatt    300

ttgaaactat ggctaaatta catattccag taatggtgga tgaagttgtt cattgtttgt    360

caccacaaaa aggacagatt tttctagata tgacatttgg ttcgggaggg cacacaaaag    420

ccattctgca gaaggagtca gatattgttc tctatgcctt ggacagagac ccaacagctt    480

atgcattagc tgaacatctt tcagagttgt atcctaaaca aatccgagct atgctgggcc    540

agttcagcca ggcagaagcc ttattaatga aagctggagt gcagccagga acttttgatg    600

gagttcttat ggatcttggg tgttcctcca tgcaacttga tactcctgaa agaggttttt    660

cccttcggaa agatggccct ttggacgtga gaatggatgg tggcaggtac cctgacatgc    720

ccactgctgc tgatgttgtg aatgctttag atcaacaggc acttgcatct atcctaagaa    780

catacgggga ggagaagcat gccaagaaaa tcgcttcagc aattgttcag gcacgcagca    840

tctaccccat caccagaacc cagcagcttg ccagcatcgt tgcagaatac tctgaaacat    900

atttcccagt ggcccaaact ctttattagg aaaatggacg aattgaatag caaatggagc    960

atttcctccc tctgctattt atacacggaa agacttacta cagcgatcta cccatattgc   1020

caccaagact ttccaggctc ttcgcatatt tgtgaacaat gagctcaatg aactctacac   1080

gggactgaag acagctcaga agtttctgag acctggtggt cgtcttgttg ccctctcctt   1140

ccattcacta gaggatcgca tcgtcaaaag atttttgctt ggaataagca tgacagaaag   1200

atttaaccta agtgttagac aacaagtgat gaaaacatct caattgggtt cagatcacga   1260

aaacacggaa gaagtctcta tgagaagagc tcctttaatg tgggaattga tacacaagaa   1320

ggtacttagt ccacaagatc aggatgtaca agataacccc agagggcgct cagccaagct   1380

tagagcagct atcaaattat aagttatcat catcttattc ttcaaatttt tttctcacaa   1440

tttctctaat ctttactcat gttatgtccc tgaatgtctt ggtataggtt taagtgtggg   1500

acagtctgaa aattgatagc atttagcatt tcttttttct caaaaagaaa ctgtaggaaa   1560

tacatgacag agaaagttac actcagggag cagcagcacc tccagactgg aaaaatgtgt   1620

taatctttgc atcatattgg actcttgaag gcaatccttc ctctggccag gaaatttttt   1680

aaaaaataat actgtgttgt gtttatctaa atacgtaaac tcaagctacc aaagagaaag   1740

atgttgtaat catatctgca tgtcctaaat tttgaattta gatattccaa tttgcatcag   1800

tctttctgtg gctcaaataa tgatgattat ggaatgaatt ttaatgtccc tacttgtgaa   1860

taattagctt tctcaaatgt aggcttttta caaattttaa attttaaaat attagtttaa   1920

atgtgtgtta tactgataaa atttcatctt tcaaattata gtctattatt ttaaagggat   1980

ttttcagtat gatatgggcc attttgttca tctatcgcaa agtaaaaatg taaaatcctt   2040

acagagaatt gtttcacaaa acttatattt catgtcaatt gtatttattt taataatagc   2100

tcacaatgcc tttagtaagt aataaagtct cttattagaa tcttgtattt tttaattgag   2160

ctaatcaaaa taattcagcc aagtctattt gaaatagaaa actgtctatt taatatagta   2220

aaatcaatgc tcccttaatg ttgttacaaa gatatggtaa ctgtaatatg ggtaaaagtt   2280

tattcaagaa aagagtactt ggtagaagat tctttaacaa attgaggaga ttgattcata   2340

attcacatgt caatttttta tagtaatatg tacttctaat ttattattta tacttaaatt   2400

gtgacctgaa agatgagttg gagataatta gtcaaagggc acatggagta tggaaggggg   2460

catgttgatt aaccatacat agaaataaat attctcttag ttatccttga aatcatattt   2520

atactattaa tttgctcagt gcactttttt caaatacaga aaaaagattc tccattatag   2580

ttacaaattt taggttggtg aatccaagtg aatgaaatat cagcataact atgtgggcaa   2640

aatagataga attaaatgca tgaattttcc tcagacttat tttatctgcc tctgtaatat   2700

ttaactttag tacccaggct tgttcactac ttctgcttta caggctttat ttaaatctga   2760

acaatcctac agggaaatca gaattaggaa aaaaatctgg agaacaatat ggttgaaata   2820

gaaacaagag aatgcaccta ggttaattcc ctgaatccta cttgaacatt gtataaattt   2880

ctctttgcat ataatacata tttgtgaatg agacatattc ccaaaaaatt cttatctctg   2940

tatgtgattg gaaaagaaaa gatcacattt gtatattcaa caatctttca cctatttcat   3000

aagtcatttt ttcaccctgt atagtatggg aattattttt tatgttaaat agaaactgaa   3060

tgtactgggt tgaatggtgt cctctccaaa attcatgtac ttcctggagc ctcagtatgt   3120

gaccttattt ggaaatactg tggttgtggt tgtaagtagc taagatgagg tcatactgga   3180

gcagggcagg cccttaatcc aatatgactg gtgttcctta taagagaaga tagggcgggc   3240

atggtggctc acgcctgtaa tcccagcact gtgggaggcc aagccaggca aatcgcttga   3300

ggctgaggag ttcaagacca gcctggccaa catggcgaaa acccatctct actaaaaata   3360

aaattagcca tgcgtggtgc ttgtaatgtc agctacccag gagtctgagg cacaagaatc   3420

actcgaacct gggaggtgga ggttgcgaga tcacaccact gcactccagt gtgagcaaca   3480

gaacgagact ctgtctcaaa aaaaaaaaaa aaaaagggaa gaaagagaag atagagacac   3540

aggggagaat gccacatgaa gctggaggca gagattggag tgatacattg tgggaaccct   3600

cagaagatag gaaaaaagca tggaatagat tctccctcag agttccagta gttgccaacc   3660

ctgctaacat ggttttgcac atctagcatc cagaacagtg agaatgtatt tctgctgttt   3720

taaggtaccc agttcatggt aatttgttac agcaatccta ggaagctaat actctgacag   3780

aaaaaaatct tggataatat gcatgagaaa aatccttcaa taaacacaaa attggtttca   3840

aaatgttttc atgtaaaaat aaattaactt ttctgtaatt agattgtgtt ttatagtaat   3900

tcttgcctgc ttcttagtct ttgttgtagg atgcataata aaatacatga atgagtttt    3959


<210>  2663
<211>  273
<212>  PRT
<213>  Homosapiens

<400>  2663

Met Leu Arg Tyr Pro Tyr Phe Cys Arg Met Tyr Lys Glu Cys Leu Ser 
1               5                   10                  15      


Cys Trp Leu Glu Ser Gly Ile Pro Asn Leu Gly Val Trp Pro Lys Arg 
            20                  25                  30          


Ile His Thr Thr Ala Glu Lys Tyr Arg Glu Tyr Glu Ala Arg Glu Gln 
        35                  40                  45              


Thr Asp Gln Thr Gln Ala Gln Glu Leu His Arg Ser Gln Asp Arg Asp 
    50                  55                  60                  


Phe Glu Thr Met Ala Lys Leu His Ile Pro Val Met Val Asp Glu Val 
65                  70                  75                  80  


Val His Cys Leu Ser Pro Gln Lys Gly Gln Ile Phe Leu Asp Met Thr 
                85                  90                  95      


Phe Gly Ser Gly Gly His Thr Lys Ala Ile Leu Gln Lys Glu Ser Asp 
            100                 105                 110         


Ile Val Leu Tyr Ala Leu Asp Arg Asp Pro Thr Ala Tyr Ala Leu Ala 
        115                 120                 125             


Glu His Leu Ser Glu Leu Tyr Pro Lys Gln Ile Arg Ala Met Leu Gly 
    130                 135                 140                 


Gln Phe Ser Gln Ala Glu Ala Leu Leu Met Lys Ala Gly Val Gln Pro 
145                 150                 155                 160 


Gly Thr Phe Asp Gly Val Leu Met Asp Leu Gly Cys Ser Ser Met Gln 
                165                 170                 175     


Leu Asp Thr Pro Glu Arg Gly Phe Ser Leu Arg Lys Asp Gly Pro Leu 
            180                 185                 190         


Asp Val Arg Met Asp Gly Gly Arg Tyr Pro Asp Met Pro Thr Ala Ala 
        195                 200                 205             


Asp Val Val Asn Ala Leu Asp Gln Gln Ala Leu Ala Ser Ile Leu Arg 
    210                 215                 220                 


Thr Tyr Gly Glu Glu Lys His Ala Lys Lys Ile Ala Ser Ala Ile Val 
225                 230                 235                 240 


Gln Ala Arg Ser Ile Tyr Pro Ile Thr Arg Thr Gln Gln Leu Ala Ser 
                245                 250                 255     


Ile Val Ala Glu Tyr Ser Glu Thr Tyr Phe Pro Val Ala Gln Thr Leu 
            260                 265                 270         


Tyr 
    


<210>  2664
<211>  532
<212>  DNA
<213>  Homosapiens

<400>  2664
gatgatcaca cccactttgc ttcactttca tgtccagagc tgcttagact gatttctgca     60

aagtgcacag gcattttcat gctgaggata aaggaccatg atcgcttgtc tggacccaga    120

aaatatttcc catttgctac acagatgccg tctcatcctt ccagagttca agacttcagc    180

agaaaaaaaa atcacctcat taaaggaaaa ttgtgcctta tccccactac tcgaagatgc    240

aaccatctgc ctggtcacag ccactttttt cctttttttc tcactccatc gtatgtgtgt    300

gtggtggggc aggggataag gggaataatc tctctccagt ataagaaggg atcaagaagc    360

aacaggactg cgggatggga tagaaaataa ttttcatctt agcaatattg agtattccag    420

tacatgagta ttgtatgttt ctcaattcac ttagatcctt aatttccctt agtcatgttt    480

tgtgattttc agtatacaaa tcttgtactc tgtattaaac cattcttgca tt            532


<210>  2665
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  2665

Met Leu Arg Ile Lys Asp His Asp Arg Leu Ser Gly Pro Arg Lys Tyr 
1               5                   10                  15      


Phe Pro Phe Ala Thr Gln Met Pro Ser His Pro Ser Arg Val Gln Asp 
            20                  25                  30          


Phe Ser Arg Lys Lys Asn His Leu Ile Lys Gly Lys Leu Cys Leu Ile 
        35                  40                  45              


Pro Thr Thr Arg Arg Cys Asn His Leu Pro Gly His Ser His Phe Phe 
    50                  55                  60                  


Pro Phe Phe Leu Thr Pro Ser Tyr Val Cys Val Val Gly Gln Gly Ile 
65                  70                  75                  80  


Arg Gly Ile Ile Ser Leu Gln Tyr Lys Lys Gly Ser Arg Ser Asn Arg 
                85                  90                  95      


Thr Ala Gly Trp Asp Arg Lys 
            100             


<210>  2666
<211>  1693
<212>  DNA
<213>  Homosapiens

<400>  2666
acgggccaag gcggcgcgtc tcgggggtgg agcctggagg tgaccgcgcc gctgcaacgc     60

ccccaccccc cgcggtcgca gtggttcagc ccgagaactt ttcattcata aaaagaaaag    120

actccgcacg gcgcgggtga gtcagaaccc agcagccgtg taccccgcag agccgccagc    180

cccgggcatg ttccgagact tcggggaacc cggcccgagc tccgggaacg gcggcgggta    240

cggcggcccc gcgcagcccc cggccgcagc gcaggcagcc cagcagaagt tccacctggt    300

gccaagcatc aacaccatga gtggcagtca ggagctgcag tggatggtac agcctcattt    360

cctggggccc agcagttacc ccaggcctct gacctaccct cagtacagcc ccccacaacc    420

ccggccagga gtcatccggg ccctggggcc gcctccaggg gtacgtcgaa ggccttgtga    480

acagatcagc ccggaggaag aggagcgccg ccgagtaagg cgcgagcgga acaagctggc    540

tgcggccaag tgcaggaacc ggaggaagga actgaccgac ttcctgcagg cggagactga    600

caaactggaa gatgagaaat ctgggctgca gcgagagatt gaggagctgc agaagcagaa    660

ggagcgccta gagctggtgc tggaagccca ccgacccatc tgcaaaatcc cggaaggagc    720

caaggagggg gacacaggca gtaccagtgg caccagcagc ccaccagccc cctgccgccc    780

tgtaccttgt atctcccttt ccccagggcc tgtgcttgaa cctgaggcac tgcacacccc    840

cacactcatg accacaccct ccctaactcc tttcaccccc agcctggtct tcacctaccc    900

cagcactcct gagccttgtg cctcagctca tcgcaagagt agcagcagca gcggagaccc    960

atcctctgac ccccttggct ctccaaccct cctcgctttg tgaggcgcct gagccctact   1020

ccctgcagat gccaccctag ccaatgtctc ctccccttcc cccaccggtc cagctggcct   1080

ggacagtatc ccacatccaa ctccagcaac ttcttctcca tccctctaat gagactgacc   1140

atattgtgct tcacagtaga gccagcttgg ggccaccaaa gctgcccact gtttctcttg   1200

agctggcctc tctagcacaa tttgcactaa atcagagaca aaatatttcc catttgtgcc   1260

agaggaatcc tggcagccca gagactttgt agatccttag aggtcctctg gagccctaac   1320

cccttccaga tcactgccac actctccatc accctcttcc tgtgatccac ccaaccctat   1380

ctcctgacag aaggtgccac tttacccacc tagaacacta actcaccagc cccactgcca   1440

gcagcagcag gtgattggac caggccattc tgccgccccc tcctgaaccg cacagctcag   1500

gaggcgccct tggcttctgt gatgagctga tctgcggatc tcagctttga gaagccttca   1560

gctccaggga atccaagcct ccacagcgag ggcagctgct atttattttc ctaaagagag   1620

tatttttata caaacctacc aaaatggaat aaaaggcttg aagctgtgaa aaaaaaaaaa   1680

aaaaaaaaaa aaa                                                      1693


<210>  2667
<211>  271
<212>  PRT
<213>  Homosapiens

<400>  2667

Met Phe Arg Asp Phe Gly Glu Pro Gly Pro Ser Ser Gly Asn Gly Gly 
1               5                   10                  15      


Gly Tyr Gly Gly Pro Ala Gln Pro Pro Ala Ala Ala Gln Ala Ala Gln 
            20                  25                  30          


Gln Lys Phe His Leu Val Pro Ser Ile Asn Thr Met Ser Gly Ser Gln 
        35                  40                  45              


Glu Leu Gln Trp Met Val Gln Pro His Phe Leu Gly Pro Ser Ser Tyr 
    50                  55                  60                  


Pro Arg Pro Leu Thr Tyr Pro Gln Tyr Ser Pro Pro Gln Pro Arg Pro 
65                  70                  75                  80  


Gly Val Ile Arg Ala Leu Gly Pro Pro Pro Gly Val Arg Arg Arg Pro 
                85                  90                  95      


Cys Glu Gln Ile Ser Pro Glu Glu Glu Glu Arg Arg Arg Val Arg Arg 
            100                 105                 110         


Glu Arg Asn Lys Leu Ala Ala Ala Lys Cys Arg Asn Arg Arg Lys Glu 
        115                 120                 125             


Leu Thr Asp Phe Leu Gln Ala Glu Thr Asp Lys Leu Glu Asp Glu Lys 
    130                 135                 140                 


Ser Gly Leu Gln Arg Glu Ile Glu Glu Leu Gln Lys Gln Lys Glu Arg 
145                 150                 155                 160 


Leu Glu Leu Val Leu Glu Ala His Arg Pro Ile Cys Lys Ile Pro Glu 
                165                 170                 175     


Gly Ala Lys Glu Gly Asp Thr Gly Ser Thr Ser Gly Thr Ser Ser Pro 
            180                 185                 190         


Pro Ala Pro Cys Arg Pro Val Pro Cys Ile Ser Leu Ser Pro Gly Pro 
        195                 200                 205             


Val Leu Glu Pro Glu Ala Leu His Thr Pro Thr Leu Met Thr Thr Pro 
    210                 215                 220                 


Ser Leu Thr Pro Phe Thr Pro Ser Leu Val Phe Thr Tyr Pro Ser Thr 
225                 230                 235                 240 


Pro Glu Pro Cys Ala Ser Ala His Arg Lys Ser Ser Ser Ser Ser Gly 
                245                 250                 255     


Asp Pro Ser Ser Asp Pro Leu Gly Ser Pro Thr Leu Leu Ala Leu 
            260                 265                 270     


<210>  2668
<211>  1568
<212>  DNA
<213>  Homosapiens

<400>  2668
agttgttgtt gaggtggcgc ggcgctaaga tggcggcggc ggcggcggcg gccgtggcgg     60

gggtggggcg cggtggcggt ggcgcggagc cacggcagga gcggagccgg gcccggggct    120

gggccggcgt cgaacgcagc gaaggccgga ggatggaacc aggtgaggag ctggaagagg    180

agggctctcc aggtggccgt gaggatggct tcaccgccga gcacctggct gcagaggcca    240

tggcagctga catggacccc tggctagtgt ttgatgcccg cacaacgcct gccactgagc    300

tggatgcctg gctggccaag tacccaccat cccaagttac ccgctatggg gaccccggtt    360

cacccaactc agagcctgtg ggctggattg cagtgtatgg gcagggctac agccccaact    420

ccggggacgt gcagggcctg caggcagcct gggaagctct gcagaccagt gggcggccca    480

tcacaccggg taccctgcgc cagctcgcca tcacccacca cgtgctctcg ggcaagtggc    540

ttatgcatct ggcaccgggc ttcaagctgg accacgcctg ggctggcatt gcccgggccg    600

tggttgaagg ccggcttcag gtggccaagg tgagcccacg tgccaaggag ggtgggcgcc    660

aggtcatctg tgtttacacg gacgacttca cggaccgctt gggtgtactg gaggcggatt    720

cagccatccg tgcagcgggc attaagtgcc tgctcaccta caagcctgat gtctacacct    780

acctgggcat ctaccgggcc aatcgctggc acctctgccc cactctctat gagagccgtt    840

tccagcttgg gggtagtgcc cgtggctccc gagtgcttga ccgtgccaac aacgtggaac    900

tgacctagag gggccaaatt ggggagactg cccactcccc cctccatgct ggggttggat    960

cctcctgtct tcctccttgt cccatgaagg ccacaccccc cagctctggg gactcctagg   1020

tcacttggga actacctgca tcttcagtcc ccttgaactt ctgccctctg ttcagggctg   1080

acacaagccc cacaggctgg ggggctccgg ttccctgagg gatgagcctt cagcctccct   1140

ttgtaatgct gctcctctcc actgcccagc accatgagtt gggtgcagac acctagaagg   1200

agagacttct tggaacgctc atcccccgct atacctcccc ttcctcctgc atctcccctt   1260

ctttccttcc ccctcaggag agagaaaact tagtgcttcc agcccttctt ggagccttca   1320

tggtccaggg gtaggggccc cactggcctg agcatgccat tttgagggga gggtagttgt   1380

gcctacttat cccctggcag aggggatgcc aggaccatgg acatgaggct tgcccatccc   1440

tgccaactta cacagcctgt accactgtcc ccccttcctt ggctactttg acatgtgcct   1500

gctcctggca tttcaataaa acccggcttg ggtctgtgtc ttgagtgttt tttaaaaaaa   1560

aaaaaaaa                                                            1568


<210>  2669
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  2669

Met Glu Pro Gly Glu Glu Leu Glu Glu Glu Gly Ser Pro Gly Gly Arg 
1               5                   10                  15      


Glu Asp Gly Phe Thr Ala Glu His Leu Ala Ala Glu Ala Met Ala Ala 
            20                  25                  30          


Asp Met Asp Pro Trp Leu Val Phe Asp Ala Arg Thr Thr Pro Ala Thr 
        35                  40                  45              


Glu Leu Asp Ala Trp Leu Ala Lys Tyr Pro Pro Ser Gln Val Thr Arg 
    50                  55                  60                  


Tyr Gly Asp Pro Gly Ser Pro Asn Ser Glu Pro Val Gly Trp Ile Ala 
65                  70                  75                  80  


Val Tyr Gly Gln Gly Tyr Ser Pro Asn Ser Gly Asp Val Gln Gly Leu 
                85                  90                  95      


Gln Ala Ala Trp Glu Ala Leu Gln Thr Ser Gly Arg Pro Ile Thr Pro 
            100                 105                 110         


Gly Thr Leu Arg Gln Leu Ala Ile Thr His His Val Leu Ser Gly Lys 
        115                 120                 125             


Trp Leu Met His Leu Ala Pro Gly Phe Lys Leu Asp His Ala Trp Ala 
    130                 135                 140                 


Gly Ile Ala Arg Ala Val Val Glu Gly Arg Leu Gln Val Ala Lys Val 
145                 150                 155                 160 


Ser Pro Arg Ala Lys Glu Gly Gly Arg Gln Val Ile Cys Val Tyr Thr 
                165                 170                 175     


Asp Asp Phe Thr Asp Arg Leu Gly Val Leu Glu Ala Asp Ser Ala Ile 
            180                 185                 190         


Arg Ala Ala Gly Ile Lys Cys Leu Leu Thr Tyr Lys Pro Asp Val Tyr 
        195                 200                 205             


Thr Tyr Leu Gly Ile Tyr Arg Ala Asn Arg Trp His Leu Cys Pro Thr 
    210                 215                 220                 


Leu Tyr Glu Ser Arg Phe Gln Leu Gly Gly Ser Ala Arg Gly Ser Arg 
225                 230                 235                 240 


Val Leu Asp Arg Ala Asn Asn Val Glu Leu Thr 
                245                 250     


<210>  2670
<211>  988
<212>  DNA
<213>  Homosapiens

<400>  2670
gggcgggagc ggcggtccag actggggagg gacgcgcacc ggccaggagg cttcaagagg     60

agggcactag ggccctgcga gcggcgtctt aaccggcggc gctaggactc cgcgggaaac    120

ggcgggggcg gagcgggcgg caccaggacc caggggaacc gcgacgggcg ggcggcgagc    180

aggcccggga gccgggaggc tgcgggcggc ggcgctggac ccgacgcggc gagagaggcc    240

ccgagatgcc gagcaagaag aagaagtaca acgcgcggtt cccgccggcg cggatcaaga    300

agatcatgca gacggacgaa gagattggga aggtggcggc ggcggtgcct gtcatcatct    360

cccgggcgct cgagctcttc ctagagtcgc tgttgaagaa ggcctgccag gtgacccagt    420

cgcggaacgc gaagaccatg accacatccc acctgaagca gtgcatcgag ctggagcagc    480

agtttgactt cttgaaggac ctggtggcat ctgttcccga catgcagggg gacggggaag    540

acaaccacat ggatggggac aagggcgccc gcaggggccg gaagccaggc agcggcggcc    600

ggaagaacgg tgggatggga acgaaaagca aggacaagaa gctgtccggg acagactcgg    660

agcaggagga tgaatctgag gacacagata ctgatgggga agaggagaca tcacaacccc    720

caccccaggc cagccacccc tctgcccact ttcagagccc cccgacaccc ttcctgccct    780

tcgcctctac tctgcctttg cccccagcgc ccccgggccc ctcagcacct gatgaagagg    840

acgaagaaga ttacgactcc tagcgccttc tgccccccag accatagccc cttttagttg    900

gttttagttg ctctgggggg aggagagaag gtagagctgt tcttaaattt attaaaaaaa    960

aaaataaaag ggaatctcag tgtctgtt                                       988


<210>  2671
<211>  205
<212>  PRT
<213>  Homosapiens

<400>  2671

Met Pro Ser Lys Lys Lys Lys Tyr Asn Ala Arg Phe Pro Pro Ala Arg 
1               5                   10                  15      


Ile Lys Lys Ile Met Gln Thr Asp Glu Glu Ile Gly Lys Val Ala Ala 
            20                  25                  30          


Ala Val Pro Val Ile Ile Ser Arg Ala Leu Glu Leu Phe Leu Glu Ser 
        35                  40                  45              


Leu Leu Lys Lys Ala Cys Gln Val Thr Gln Ser Arg Asn Ala Lys Thr 
    50                  55                  60                  


Met Thr Thr Ser His Leu Lys Gln Cys Ile Glu Leu Glu Gln Gln Phe 
65                  70                  75                  80  


Asp Phe Leu Lys Asp Leu Val Ala Ser Val Pro Asp Met Gln Gly Asp 
                85                  90                  95      


Gly Glu Asp Asn His Met Asp Gly Asp Lys Gly Ala Arg Arg Gly Arg 
            100                 105                 110         


Lys Pro Gly Ser Gly Gly Arg Lys Asn Gly Gly Met Gly Thr Lys Ser 
        115                 120                 125             


Lys Asp Lys Lys Leu Ser Gly Thr Asp Ser Glu Gln Glu Asp Glu Ser 
    130                 135                 140                 


Glu Asp Thr Asp Thr Asp Gly Glu Glu Glu Thr Ser Gln Pro Pro Pro 
145                 150                 155                 160 


Gln Ala Ser His Pro Ser Ala His Phe Gln Ser Pro Pro Thr Pro Phe 
                165                 170                 175     


Leu Pro Phe Ala Ser Thr Leu Pro Leu Pro Pro Ala Pro Pro Gly Pro 
            180                 185                 190         


Ser Ala Pro Asp Glu Glu Asp Glu Glu Asp Tyr Asp Ser 
        195                 200                 205 


<210>  2672
<211>  1726
<212>  DNA
<213>  Homosapiens

<400>  2672
agttctacgg tgcggatggg ggatggggca ggatggggca ggacaccgat atgctaaata     60

cctaccaaca gttggttagg accccgtcgg tgcgaccagg gcaggacgtg cggctccagg    120

ctccaggaac cagaacgggg ctgctcaagc tgctgtcgac cgtctctcag gacaagcagg    180

gctgcctggg gagtggtgat ggtgtgccaa atcaagacct gcagcagagg cctcagagct    240

caaggcagac agcaaagaag gaccgcaagc ccaggggcca gagcaagaaa ggacagggct    300

ctgaagagtc tgaagatcac ttcccgcttc ttcctcggaa accctccttc cccttccagt    360

gggcctggga gagcatcgcc acagatgtcc gggctgtgct tcagccaagc tccccaaccc    420

ctggccacca agccctgccc atgccctcct cgttctccca gcgtcagtcc aggcgcaagt    480

ccacggccaa cctcccagag gcccatggct gctgctggaa gacagaggcg caaaacctga    540

aggcgagaca gcagctggga gcctggggcg gtgtctccat ccctactggc aaaggggagc    600

taggatcaga gccccccagt ggtctccagc tgcctgggag gaggccagga tcaggatcgg    660

cgtccgacaa gcaggtccag ctgcaaagcc tgggtgctga ggaggccgag aggggtctga    720

gttctggggt gctgccccag cgccccagga gggggtcgat ctcagaggag gagcaatttt    780

cagaggccac agaggaggct gaggagggag agcacaggac tccctgcaga aggagggctg    840

gttgtcagag aaaggggcag atttctggag aggaagcctc cgatgaggga gaagtgcagg    900

gccagagcca ggggagcagc cccagcttca acaacctccg aaggcgacaa tggaggaaga    960

caagggccaa ggagctgcag gggccatggg acctggagaa gctgcacagg cagctacaga   1020

gagacctgga ctgtggcccc caaaagctgc cctggaagac tttgagggct gccttccagg   1080

cctccaagcg gaatggaaag gcctatgcct cgggatacga tgaaactttc gtgtctgcca   1140

acctccctaa tcgcaccttc cacaaacgac aggaagccac caggagcctg ctgcaggcct   1200

gggagcggca gcggcaggag gagcggcagc aggccgagct gcggcgggcc cggacacagc   1260

atgtacagcg gcaggtggcc cactgcctgg cagcctacgc acccagaggg agccggggcc   1320

ctggggcggc ccagcgcaag ctggaggagc tgaggcgcca ggagcgacag cgctttgctg   1380

agtaccaggc ggagctgcaa ggcatccagc acagggtgca ggcccggccc ttcctgttcc   1440

agcaggctat gcaggccaat gcccggctca ccgtcactcg gcgcttctcc caggtgctgt   1500

cagcactggg gctggatgag gagcagctgc tgtctgaggc aggaaaggtg gacagagagg   1560

gcacccccag gaaacccagg agccacaggt caatgggggt gagaatggag cactctcctc   1620

agaggccccc aaggacagaa cccaccggca gccagcctga caggcactac aaccccagcc   1680

tggacccgga gtgcagtccc tgagataaaa ttaaaggctt tatggc                  1726


<210>  2673
<211>  556
<212>  PRT
<213>  Homosapiens

<400>  2673

Met Gly Gln Asp Thr Asp Met Leu Asn Thr Tyr Gln Gln Leu Val Arg 
1               5                   10                  15      


Thr Pro Ser Val Arg Pro Gly Gln Asp Val Arg Leu Gln Ala Pro Gly 
            20                  25                  30          


Thr Arg Thr Gly Leu Leu Lys Leu Leu Ser Thr Val Ser Gln Asp Lys 
        35                  40                  45              


Gln Gly Cys Leu Gly Ser Gly Asp Gly Val Pro Asn Gln Asp Leu Gln 
    50                  55                  60                  


Gln Arg Pro Gln Ser Ser Arg Gln Thr Ala Lys Lys Asp Arg Lys Pro 
65                  70                  75                  80  


Arg Gly Gln Ser Lys Lys Gly Gln Gly Ser Glu Glu Ser Glu Asp His 
                85                  90                  95      


Phe Pro Leu Leu Pro Arg Lys Pro Ser Phe Pro Phe Gln Trp Ala Trp 
            100                 105                 110         


Glu Ser Ile Ala Thr Asp Val Arg Ala Val Leu Gln Pro Ser Ser Pro 
        115                 120                 125             


Thr Pro Gly His Gln Ala Leu Pro Met Pro Ser Ser Phe Ser Gln Arg 
    130                 135                 140                 


Gln Ser Arg Arg Lys Ser Thr Ala Asn Leu Pro Glu Ala His Gly Cys 
145                 150                 155                 160 


Cys Trp Lys Thr Glu Ala Gln Asn Leu Lys Ala Arg Gln Gln Leu Gly 
                165                 170                 175     


Ala Trp Gly Gly Val Ser Ile Pro Thr Gly Lys Gly Glu Leu Gly Ser 
            180                 185                 190         


Glu Pro Pro Ser Gly Leu Gln Leu Pro Gly Arg Arg Pro Gly Ser Gly 
        195                 200                 205             


Ser Ala Ser Asp Lys Gln Val Gln Leu Gln Ser Leu Gly Ala Glu Glu 
    210                 215                 220                 


Ala Glu Arg Gly Leu Ser Ser Gly Val Leu Pro Gln Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ser Ile Ser Glu Glu Glu Gln Phe Ser Glu Ala Thr Glu Glu Ala 
                245                 250                 255     


Glu Glu Gly Glu His Arg Thr Pro Cys Arg Arg Arg Ala Gly Cys Gln 
            260                 265                 270         


Arg Lys Gly Gln Ile Ser Gly Glu Glu Ala Ser Asp Glu Gly Glu Val 
        275                 280                 285             


Gln Gly Gln Ser Gln Gly Ser Ser Pro Ser Phe Asn Asn Leu Arg Arg 
    290                 295                 300                 


Arg Gln Trp Arg Lys Thr Arg Ala Lys Glu Leu Gln Gly Pro Trp Asp 
305                 310                 315                 320 


Leu Glu Lys Leu His Arg Gln Leu Gln Arg Asp Leu Asp Cys Gly Pro 
                325                 330                 335     


Gln Lys Leu Pro Trp Lys Thr Leu Arg Ala Ala Phe Gln Ala Ser Lys 
            340                 345                 350         


Arg Asn Gly Lys Ala Tyr Ala Ser Gly Tyr Asp Glu Thr Phe Val Ser 
        355                 360                 365             


Ala Asn Leu Pro Asn Arg Thr Phe His Lys Arg Gln Glu Ala Thr Arg 
    370                 375                 380                 


Ser Leu Leu Gln Ala Trp Glu Arg Gln Arg Gln Glu Glu Arg Gln Gln 
385                 390                 395                 400 


Ala Glu Leu Arg Arg Ala Arg Thr Gln His Val Gln Arg Gln Val Ala 
                405                 410                 415     


His Cys Leu Ala Ala Tyr Ala Pro Arg Gly Ser Arg Gly Pro Gly Ala 
            420                 425                 430         


Ala Gln Arg Lys Leu Glu Glu Leu Arg Arg Gln Glu Arg Gln Arg Phe 
        435                 440                 445             


Ala Glu Tyr Gln Ala Glu Leu Gln Gly Ile Gln His Arg Val Gln Ala 
    450                 455                 460                 


Arg Pro Phe Leu Phe Gln Gln Ala Met Gln Ala Asn Ala Arg Leu Thr 
465                 470                 475                 480 


Val Thr Arg Arg Phe Ser Gln Val Leu Ser Ala Leu Gly Leu Asp Glu 
                485                 490                 495     


Glu Gln Leu Leu Ser Glu Ala Gly Lys Val Asp Arg Glu Gly Thr Pro 
            500                 505                 510         


Arg Lys Pro Arg Ser His Arg Ser Met Gly Val Arg Met Glu His Ser 
        515                 520                 525             


Pro Gln Arg Pro Pro Arg Thr Glu Pro Thr Gly Ser Gln Pro Asp Arg 
    530                 535                 540                 


His Tyr Asn Pro Ser Leu Asp Pro Glu Cys Ser Pro 
545                 550                 555     


<210>  2674
<211>  3561
<212>  DNA
<213>  Homosapiens

<400>  2674
ttttgcgttg tctgggctcg gcggcagccg ggctcggagt ggacgtgcca ctatggggtc     60

gtccaagaag catcgcggag agaaggaggc ggccgggacg acggcggcgg ccggcaccgg    120

gggtgccacc gagcagccgc cgcggcaccg ggaacacaaa aaacacaagc accggagtgg    180

cggcagtggc ggtagcggtg gcgaacgacg gaagcggagc cgggaacgtg ggggcgagcg    240

cgggagcggg cggcgcgggg ccgaagctga ggcccggagc agcacgcacg ggcgggagcg    300

cagccaggca gagccctccg agcggcgcgt gaagcgggag aagcgcgatg acggctacga    360

ggccgctgcc agctccaaaa ctagctcagg cgatgcctcc tcactcagca tcgaggagac    420

taacaaactc cgggcaaagt tggggctgaa acccttggag gttaatgcca tcaagaagga    480

ggcgggcacc aaggaggagc ccgtgacagc tgatgtcatc aaccctatgg ccttgcgaca    540

gcgagaggag ctgcgggaga agctggcggc tgccaaggag aagcgcctgc tgaaccaaaa    600

gctggggaag ataaagaccc taggagagga tgacccctgg ctggacgaca ctgcagcctg    660

gatcgagagg agccggcagc tgcagaagga gaaggacctg gcagagaaga gggccaagtt    720

actggaggag atggaccaag agtttggtgt cagcactctg gtggaggagg agttcgggca    780

gaggcggcag gacctgtaca gtgcccggga cctgcagggc ctcaccgtgg agcatgccat    840

tgattccttc cgagaagggg agacaatgat tcttaccctc aaggacaaag gcgtgctgca    900

ggaggaggag gacgtgctgg tgaacgtgaa cctggtggat aaggagcggg cagagaaaaa    960

tgtggagctg cggaagaaga agcctgacta cctgccctat gccgaggacg agagcgtgga   1020

cgacctggcg cagcaaaaac ctcgctctat cctgtccaag tatgacgaag agcttgaagg   1080

ggagcggcca cattccttcc gcttggagca gggcggcacg gctgatggcc tgcgggagcg   1140

ggagctggag gagatccggg ccaagctgcg gctgcaggct cagtccctga gcacagtggg   1200

gccccggctg gcctccgaat acctcacgcc tgaggagatg gtgaccttta aaaagaccaa   1260

gcggagggtg aagaaaatcc gcaagaagga gaaggaggta gtagtgcggg cagatgactt   1320

gctgcctctc ggggaccaga ctcaggatgg ggactttggt tccagactgc ggggacgggg   1380

tcgccgccga gtgtccgaag tggaggagga gaaggagcct gtgcctcagc ccctgccgtc   1440

ggacgacacc cgagtggaga acatggacat cagtgatgag gaggaaggtg gagctccacc   1500

gccggggtcc ccgcaggtgc tggaggagga cgaggcggag ctggagctgc agaagcagct   1560

ggagaaggga cgccggctgc gacagttaca gcagctacag cagctgcgag acagtggcga   1620

gaaggtggtg gagattgtga agaagctgga gtctcgccag cggggctggg aggaggatga   1680

ggatcccgag cggaaggggg ccatcgtgtt caacgccacg tccgagttct gccgcacctt   1740

gggggagatc cccacctacg ggctggctgg caatcgcgag gagcaggagg agctcatgga   1800

ctttgaacgg gatgaggagc gctcagccaa cggtggctcc gaatctgacg gggaggagaa   1860

catcggctgg agcacggtga acctggacga ggagaagcag cagcaggatt tctctgcttc   1920

ctccaccacc atcctggacg aggaaccgat cgtgaatagg gggctggcag ctgccctgct   1980

cctgtgtcag aacaaagggc tgctggagac cacagtgcag aaggtggccc gggtgaaggc   2040

ccccaacaag tcgctgccct cagccgtgta ctgcatcgag gataagatgg ccatcgatga   2100

caagtacagc cggagggagg aataccgagg cttcacacag gacttcaagg agaaggacgg   2160

ctacaaaccc gacgttaaga tcgaatacgt ggatgagacg ggccggaaac tcacacccaa   2220

ggaggctttc cggcagctgt cgcaccgctt ccatggcaag ggctcaggca agatgaagac   2280

agagcggcgg atgaagaagc tggacgagga ggcgctcctg aagaagatga gctccagcga   2340

cacgcccctg ggcaccgtgg ccctgctcca ggagaagcag aaggctcaga agacccccta   2400

catcgtgctc agcggcagcg gcaagagcat gaacgcgaac accatcacca agtgacagcg   2460

ccctcccgcc ccggccctgc ctcaaccttc atattaaata aagctccctc cttatttttt   2520

cctccctggt cgtggtacag attccagggt tggatctttg gttgggtgtg gcacagagtc   2580

tggctcctgc taggtgagac ctggccgtca aatgacacaa acaactaaac gatggaagag   2640

agagcgagcc cgggtcctct aaggctcctt ccttctcccc tggctgtcgg tcacacctct   2700

gcagggccgg ctctctgata gaaagtggaa ggcggtttta gaaactcatc accctgctct   2760

ctcctggcct cgggggctgc acaggtcact gtcctgtaat gtctcccggt cagggcagcc   2820

caggactgcc cagcctggtg ggctggggat tgggctttgg gtagggcaca ggtgccacct   2880

tctgtcctgg ctgtcctgtg ccaccctggt ctgtgtctag aggagtgaaa ctcccagggt   2940

tgggctggga gtatttggtg cacgcggtat ggggagggct gagctcagtg cctcctggga   3000

gacttgtccc gtgtacagtg acccagaaag atgagattcc ttggcctgaa ctctgtgata   3060

gagtgtgact gagctgctgg gggacatgtg agcctcaaat ccatagaaag acaaacggcc   3120

accttgggtg cccaggatac tggtgcccgg ccccacgtac acccacatac ttctcagatg   3180

gctcccacat tttaagattt taaaaatgaa accaaaaaat aaattgaaga aaactgtaaa   3240

ctttaaagaa taatcagctg ggcgcagtgg ctcatgcttg taatcacagc actttaggag   3300

gctgaggcag gaggactgtt tgagcccagg agtttgagac caacctgagt aaggtggcaa   3360

aaccccatct ctaccaaaaa tacaaagatt agccaggcgt ggtggtgagc gcctgtagtc   3420

ccagctactt gggatgctga ggtgggagga tcacttgaac ctgggagaca caggctgcag   3480

tgggccctga ttgagccacc acactgcagc ctaggtgaca gtcagaccct gtctcaaaaa   3540

aaataaaaaa aatttaaaat a                                             3561


<210>  2675
<211>  800
<212>  PRT
<213>  Homosapiens

<400>  2675

Met Gly Ser Ser Lys Lys His Arg Gly Glu Lys Glu Ala Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Ala Gly Thr Gly Gly Ala Thr Glu Gln Pro Pro Arg His 
            20                  25                  30          


Arg Glu His Lys Lys His Lys His Arg Ser Gly Gly Ser Gly Gly Ser 
        35                  40                  45              


Gly Gly Glu Arg Arg Lys Arg Ser Arg Glu Arg Gly Gly Glu Arg Gly 
    50                  55                  60                  


Ser Gly Arg Arg Gly Ala Glu Ala Glu Ala Arg Ser Ser Thr His Gly 
65                  70                  75                  80  


Arg Glu Arg Ser Gln Ala Glu Pro Ser Glu Arg Arg Val Lys Arg Glu 
                85                  90                  95      


Lys Arg Asp Asp Gly Tyr Glu Ala Ala Ala Ser Ser Lys Thr Ser Ser 
            100                 105                 110         


Gly Asp Ala Ser Ser Leu Ser Ile Glu Glu Thr Asn Lys Leu Arg Ala 
        115                 120                 125             


Lys Leu Gly Leu Lys Pro Leu Glu Val Asn Ala Ile Lys Lys Glu Ala 
    130                 135                 140                 


Gly Thr Lys Glu Glu Pro Val Thr Ala Asp Val Ile Asn Pro Met Ala 
145                 150                 155                 160 


Leu Arg Gln Arg Glu Glu Leu Arg Glu Lys Leu Ala Ala Ala Lys Glu 
                165                 170                 175     


Lys Arg Leu Leu Asn Gln Lys Leu Gly Lys Ile Lys Thr Leu Gly Glu 
            180                 185                 190         


Asp Asp Pro Trp Leu Asp Asp Thr Ala Ala Trp Ile Glu Arg Ser Arg 
        195                 200                 205             


Gln Leu Gln Lys Glu Lys Asp Leu Ala Glu Lys Arg Ala Lys Leu Leu 
    210                 215                 220                 


Glu Glu Met Asp Gln Glu Phe Gly Val Ser Thr Leu Val Glu Glu Glu 
225                 230                 235                 240 


Phe Gly Gln Arg Arg Gln Asp Leu Tyr Ser Ala Arg Asp Leu Gln Gly 
                245                 250                 255     


Leu Thr Val Glu His Ala Ile Asp Ser Phe Arg Glu Gly Glu Thr Met 
            260                 265                 270         


Ile Leu Thr Leu Lys Asp Lys Gly Val Leu Gln Glu Glu Glu Asp Val 
        275                 280                 285             


Leu Val Asn Val Asn Leu Val Asp Lys Glu Arg Ala Glu Lys Asn Val 
    290                 295                 300                 


Glu Leu Arg Lys Lys Lys Pro Asp Tyr Leu Pro Tyr Ala Glu Asp Glu 
305                 310                 315                 320 


Ser Val Asp Asp Leu Ala Gln Gln Lys Pro Arg Ser Ile Leu Ser Lys 
                325                 330                 335     


Tyr Asp Glu Glu Leu Glu Gly Glu Arg Pro His Ser Phe Arg Leu Glu 
            340                 345                 350         


Gln Gly Gly Thr Ala Asp Gly Leu Arg Glu Arg Glu Leu Glu Glu Ile 
        355                 360                 365             


Arg Ala Lys Leu Arg Leu Gln Ala Gln Ser Leu Ser Thr Val Gly Pro 
    370                 375                 380                 


Arg Leu Ala Ser Glu Tyr Leu Thr Pro Glu Glu Met Val Thr Phe Lys 
385                 390                 395                 400 


Lys Thr Lys Arg Arg Val Lys Lys Ile Arg Lys Lys Glu Lys Glu Val 
                405                 410                 415     


Val Val Arg Ala Asp Asp Leu Leu Pro Leu Gly Asp Gln Thr Gln Asp 
            420                 425                 430         


Gly Asp Phe Gly Ser Arg Leu Arg Gly Arg Gly Arg Arg Arg Val Ser 
        435                 440                 445             


Glu Val Glu Glu Glu Lys Glu Pro Val Pro Gln Pro Leu Pro Ser Asp 
    450                 455                 460                 


Asp Thr Arg Val Glu Asn Met Asp Ile Ser Asp Glu Glu Glu Gly Gly 
465                 470                 475                 480 


Ala Pro Pro Pro Gly Ser Pro Gln Val Leu Glu Glu Asp Glu Ala Glu 
                485                 490                 495     


Leu Glu Leu Gln Lys Gln Leu Glu Lys Gly Arg Arg Leu Arg Gln Leu 
            500                 505                 510         


Gln Gln Leu Gln Gln Leu Arg Asp Ser Gly Glu Lys Val Val Glu Ile 
        515                 520                 525             


Val Lys Lys Leu Glu Ser Arg Gln Arg Gly Trp Glu Glu Asp Glu Asp 
    530                 535                 540                 


Pro Glu Arg Lys Gly Ala Ile Val Phe Asn Ala Thr Ser Glu Phe Cys 
545                 550                 555                 560 


Arg Thr Leu Gly Glu Ile Pro Thr Tyr Gly Leu Ala Gly Asn Arg Glu 
                565                 570                 575     


Glu Gln Glu Glu Leu Met Asp Phe Glu Arg Asp Glu Glu Arg Ser Ala 
            580                 585                 590         


Asn Gly Gly Ser Glu Ser Asp Gly Glu Glu Asn Ile Gly Trp Ser Thr 
        595                 600                 605             


Val Asn Leu Asp Glu Glu Lys Gln Gln Gln Asp Phe Ser Ala Ser Ser 
    610                 615                 620                 


Thr Thr Ile Leu Asp Glu Glu Pro Ile Val Asn Arg Gly Leu Ala Ala 
625                 630                 635                 640 


Ala Leu Leu Leu Cys Gln Asn Lys Gly Leu Leu Glu Thr Thr Val Gln 
                645                 650                 655     


Lys Val Ala Arg Val Lys Ala Pro Asn Lys Ser Leu Pro Ser Ala Val 
            660                 665                 670         


Tyr Cys Ile Glu Asp Lys Met Ala Ile Asp Asp Lys Tyr Ser Arg Arg 
        675                 680                 685             


Glu Glu Tyr Arg Gly Phe Thr Gln Asp Phe Lys Glu Lys Asp Gly Tyr 
    690                 695                 700                 


Lys Pro Asp Val Lys Ile Glu Tyr Val Asp Glu Thr Gly Arg Lys Leu 
705                 710                 715                 720 


Thr Pro Lys Glu Ala Phe Arg Gln Leu Ser His Arg Phe His Gly Lys 
                725                 730                 735     


Gly Ser Gly Lys Met Lys Thr Glu Arg Arg Met Lys Lys Leu Asp Glu 
            740                 745                 750         


Glu Ala Leu Leu Lys Lys Met Ser Ser Ser Asp Thr Pro Leu Gly Thr 
        755                 760                 765             


Val Ala Leu Leu Gln Glu Lys Gln Lys Ala Gln Lys Thr Pro Tyr Ile 
    770                 775                 780                 


Val Leu Ser Gly Ser Gly Lys Ser Met Asn Ala Asn Thr Ile Thr Lys 
785                 790                 795                 800 


<210>  2676
<211>  2836
<212>  DNA
<213>  Homosapiens

<400>  2676
gttggactgg tgggaactgg gaacactgga gacctgattt ctaactgacg ctaccgtcgc     60

ggccgccggc aagttccttt actgtgtttt cttggttcag ccttgaagtg agtcgtggac    120

gatcctctct cagcgtccag cctagacggc ggtgttgctc cggcagcgtt cctgggagcc    180

gagggccaga gactaagttc ctgggttctg agcctgccat ccaaggaact caggaggagg    240

agttgacagt ctcttcgttc ctaaccagtg tgggacgact tcagcatgtc tcaggccacc    300

aagaggaagc atgtggtgaa ggaggtgcta ggggagcaca tagtgccctc cgaccagcag    360

cagattgtca gggtactcag gaccccaggg aacaatctgc atgaggtgga gacagcccaa    420

gggcagcgct tcctggtgag catgccctcc aaataccgca agaacatctg gatcaagaga    480

ggggactttc tcattgttga ccccattgaa gagggagaaa aggtgaaggc tgaaatctcg    540

tttgtgctct gcaaggacca cgtgcgctct ctgcagaagg aggggttttg gcctgaggcc    600

ttctctgaag tggctgagaa acacaacaac aggaacagac aaactcaacc agaactccca    660

gctgagccac agttatcagg agaggagtcc agctcagaag atgattctga cctgtttgtt    720

aacacaaacc gcagacagta tcatgagagt gaggaggaga gtgaagagga ggaggcagcc    780

tgagactcca ggacccaatt ctccacttgc tcagggactg gcccctggct cttctgggct    840

tggacattcc cagggtgctc tgcacatctt cacccctgca tgaggacaaa gcagggcacc    900

tctctgaact gatcttttga ttcagagaat taaacccctg gtgggttggt gacttgttct    960

ggtgtctgag tggctctctc gggggaggga gattgtgatg aagtgaaaaa ctgctcccta   1020

tttattagag accttgtggg tgggtgggct gaatggggag gaaatgggaa atggctggag   1080

tctttcccag gtggtttgtt ctttcttatt gggcacttag aaagtgccag gccgtgctct   1140

gggccttctt gcatgtgttt aacagctggg agcactcctg cttccttgcc tgcttgcagt   1200

tcataccaat ttaagcattc aggatgacag ccctaggacc taacacccac ctgcctctaa   1260

gagacgctca ggagcccatg gtgcctcgtg ctgctctccc cacctttcta gtcaccctgt   1320

gtacgggagt gctcacctcc agctactgtg tccatcccca catacgacct catctctccc   1380

actctgcacc atctatcact tccagaaggt ggctggcaaa tctctctatc cttaactttg   1440

ttttgaatgg tccatccatc tcctgacttt atttgaaacc tgattattcc ctgaggacat   1500

tgattgtctt ataacctttt aaatagaggc tgcttttcca ccctcaccct tcattcttct   1560

aaccagccct gacattctca tgagtaacct tctgccttca cttccctctt gtgtagcatc   1620

aattccgtag tccaccctac acccctctgt ctccctccat tctgttccgc tagtaaaacc   1680

ctaaccctgg gtaaacccaa tcattcacct ctgtgcccaa acccaagtca ccatcattag   1740

gtgagaaaac agccagcctg gccaccagtt gtaccttacg tttatcatta caaacctcag   1800

atggacacta agcactgccc agcagatcta ctctgggatg tctgtttcaa aacttctgtc   1860

ttatctatca attccccctt gtggtagtta ccacaacaca tgcctcatta agaaacagca   1920

accatcagag ggaatgcctg cctccctgtt accagctctg cagatgtgca catatcttcc   1980

tgtcgtaagc caatgggact taaaccttac ctcttgtgtt ttggagacta tctttttttt   2040

tttttttttt tttttgagag agtgtctccc tgtgttgctc aggctggagt gcagtggtgt   2100

gatctcggct cactgtaacc ttcacctact gggttcaagt aactctcctg cctcagcctc   2160

ccgagtagct tggactacag gcgtgcacca ccacacctgg ctaacttttt gtatttttag   2220

tagagacggg gttttgccat gttgcccggg ctggtctcga actcctgacc ttaaatgagc   2280

ctcctgcctc agcctcccaa actgctggga ttacaggcgt gtgccaccat gcctggctaa   2340

tttttatatt ttcagtagag acgaggtttt gccatgttgg ccaggctggt ctcgaactcc   2400

tgacctcaag tggtccaccc accttggcct cctagagtgc tgggattaca ggtgtgagcc   2460

actgtgccca gcctcttttg ctttcttaaa gactttggtc gggtatttgt gttgttgagt   2520

attgtgtctg ggtgtgggta tttgattctt tttttgtttt gtgtttttgg ctgtcctgtc   2580

tattggatgt gatatgttat ggatgtgatg tgttagtgtc gagcgtgctg tagaatctcc   2640

catctctgaa acaggcgtga aaacctgtac tgattcccac gtcctccagc taccacttca   2700

tttgtctgtt tctcatttac ttcctcttat agcgtggctt taaacatata tacatttgta   2760

tatatgtata tatgaatata atgtataaaa tgtatgtaga tgtatataca aaaaataaac   2820

gagatgggtt aaagat                                                   2836


<210>  2677
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  2677

Met Ser Gln Ala Thr Lys Arg Lys His Val Val Lys Glu Val Leu Gly 
1               5                   10                  15      


Glu His Ile Val Pro Ser Asp Gln Gln Gln Ile Val Arg Val Leu Arg 
            20                  25                  30          


Thr Pro Gly Asn Asn Leu His Glu Val Glu Thr Ala Gln Gly Gln Arg 
        35                  40                  45              


Phe Leu Val Ser Met Pro Ser Lys Tyr Arg Lys Asn Ile Trp Ile Lys 
    50                  55                  60                  


Arg Gly Asp Phe Leu Ile Val Asp Pro Ile Glu Glu Gly Glu Lys Val 
65                  70                  75                  80  


Lys Ala Glu Ile Ser Phe Val Leu Cys Lys Asp His Val Arg Ser Leu 
                85                  90                  95      


Gln Lys Glu Gly Phe Trp Pro Glu Ala Phe Ser Glu Val Ala Glu Lys 
            100                 105                 110         


His Asn Asn Arg Asn Arg Gln Thr Gln Pro Glu Leu Pro Ala Glu Pro 
        115                 120                 125             


Gln Leu Ser Gly Glu Glu Ser Ser Ser Glu Asp Asp Ser Asp Leu Phe 
    130                 135                 140                 


Val Asn Thr Asn Arg Arg Gln Tyr His Glu Ser Glu Glu Glu Ser Glu 
145                 150                 155                 160 


Glu Glu Glu Ala Ala 
                165 


<210>  2678
<211>  1192
<212>  DNA
<213>  Homosapiens

<400>  2678
ccagtgttcc cagttcccac cagtccaact gcgaggagtg cgacgtgagt ctgagtctga     60

tccctccgaa aaccgtactt ccggcgctgt ctcggaggcc tcccgtcccc tcccttgtcc    120

gtcttctaac tcttccccac gccaggtccg tcaagcctaa gtccttgagt tccgggtccg    180

ggcagcagag aaaggaagtc ctctccctgg aggcctatct ccctcagaac ggcgcgagaa    240

gcgagacctt agaaggcagc gcttcccgcg aaggaccgga aaggagcgcc tactaaggac    300

gccgtcgagg tccggggcgc ctcaactcta tagctctaac tggctagaag tgcccaacgt    360

ggaatgtttc ttttttaaag gcggctcttg aagcgacccg gaagcggaag tggaagaaag    420

ttctagtggc ttgaggtatc cgcagagcgg ccgggtggcg ggaggaaccg ttacgggaac    480

tgaagttgcg gattaagcct gatcaagatg acaacctccc aaaagcaccg agacttcgtg    540

gcagagccca tgggggagaa gccagtgggg agcctggctg ggattggtga agtcctgggc    600

aagaagctgg aggaaagggg ttttgacaag gcctatgttg tccttggcca gtttctggtg    660

ctaaagaaag atgaagacct cttccgggaa tggctgaaag acacttgtgg cgccaatgcc    720

aagcagtccc gggactgctt cggatgcctt cgagagtggt gcgacgcctt cttgtgatgc    780

tctctgggaa gctctcaatc cccagccctc atccagagtt tgcagccgag tagggactcc    840

tcccctgtcc tctacgaagg aaaagattgc tattgtcgta ctcacctccg acgtactccg    900

gggtcttttg ggagttttct cccctaacca tttcaacttt tttttggatt ctcgctcttg    960

catgcctccc ccgtcctttt tcccttgcca gttccctggt gacagttacc agctttcctg   1020

aatggattcc cggccccatc cctcaccccc accctcactt tcaatccgtt tgataccatt   1080

tggctccttt tttggcagaa cagtcactgt ccttgtaaag ttttttagat caataaagtc   1140

agtggctttc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa           1192


<210>  2679
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  2679

Met Thr Thr Ser Gln Lys His Arg Asp Phe Val Ala Glu Pro Met Gly 
1               5                   10                  15      


Glu Lys Pro Val Gly Ser Leu Ala Gly Ile Gly Glu Val Leu Gly Lys 
            20                  25                  30          


Lys Leu Glu Glu Arg Gly Phe Asp Lys Ala Tyr Val Val Leu Gly Gln 
        35                  40                  45              


Phe Leu Val Leu Lys Lys Asp Glu Asp Leu Phe Arg Glu Trp Leu Lys 
    50                  55                  60                  


Asp Thr Cys Gly Ala Asn Ala Lys Gln Ser Arg Asp Cys Phe Gly Cys 
65                  70                  75                  80  


Leu Arg Glu Trp Cys Asp Ala Phe Leu 
                85                  


<210>  2680
<211>  627
<212>  DNA
<213>  Homosapiens

<400>  2680
gcggccgcaa gctcggcact cacggctctg agggctccga cggcactgac ggccatggcg     60

cgttcgaacc tcccgctggc gctgggcctg gccctggtcg cattctgcct cctggcgctg    120

ccacgcgacg cccgggcccg gccgcaggag cgcatggtcg gagaactccg ggacctgtcg    180

cccgacgacc cgcaggtgca gaaggcggcg caggcggccg tggccagcta caacatgggc    240

agcaacagca tctactactt ccgagacacg cacatcatca aggcgcagag ccagctggtg    300

gccggcatca agtacttcct gacgatggag atggggagca cagactgccg caagaccagg    360

gtcactggag accacgtcga cctcaccact tgccccctgg cagcaggggc gcagcaggag    420

aagctgcgct gtgactttga ggtccttgtg gttccctggc agaactcctc tcagctccta    480

aagcacaact gtgtgcagat gtgataagtc cccgagggcg aaggccattg ggtttggggc    540

catggtggag ggcacttcag gtccgtgggc cgtatctgtc acaataaatg gccagtgctg    600

cttcttgcaa aaaaaaaaaa aaaaaaa                                        627


<210>  2681
<211>  149
<212>  PRT
<213>  Homosapiens

<400>  2681

Met Ala Arg Ser Asn Leu Pro Leu Ala Leu Gly Leu Ala Leu Val Ala 
1               5                   10                  15      


Phe Cys Leu Leu Ala Leu Pro Arg Asp Ala Arg Ala Arg Pro Gln Glu 
            20                  25                  30          


Arg Met Val Gly Glu Leu Arg Asp Leu Ser Pro Asp Asp Pro Gln Val 
        35                  40                  45              


Gln Lys Ala Ala Gln Ala Ala Val Ala Ser Tyr Asn Met Gly Ser Asn 
    50                  55                  60                  


Ser Ile Tyr Tyr Phe Arg Asp Thr His Ile Ile Lys Ala Gln Ser Gln 
65                  70                  75                  80  


Leu Val Ala Gly Ile Lys Tyr Phe Leu Thr Met Glu Met Gly Ser Thr 
                85                  90                  95      


Asp Cys Arg Lys Thr Arg Val Thr Gly Asp His Val Asp Leu Thr Thr 
            100                 105                 110         


Cys Pro Leu Ala Ala Gly Ala Gln Gln Glu Lys Leu Arg Cys Asp Phe 
        115                 120                 125             


Glu Val Leu Val Val Pro Trp Gln Asn Ser Ser Gln Leu Leu Lys His 
    130                 135                 140                 


Asn Cys Val Gln Met 
145                 


<210>  2682
<211>  2630
<212>  DNA
<213>  Homosapiens

<400>  2682
gaatagtcag gcctttctgg aagcccagtg ccacagtctg cactgagctt ggctcaggaa     60

agaagggaaa tccaggcggg gcctgttggg cccaggtctt gagctctttt ggctccagag    120

ttcccaacac agtcatggat caaaactcag tgcctgaaaa ggctcagaat gaggcagaca    180

ccaataacgc agataggttc tttcgctctc actcatcacc cccacaccac aggccaggcc    240

acagcagagc tctccaccat tacgagttgc accatcacgg cgtgccccac caacgtggtg    300

aatctcacca ccctccggag ttccaagact tccacgacca agccttgtcc tcccatgtcc    360

accaatctca ccaccacagc gaggcacgga atcacggcag agcccatggc cccacaggct    420

ttggtctggc tccctctcaa ggcgccgtcc cctcccaccg ttcctacggt gaggactacc    480

atgatgagct ccaacgtgat ggcaggaggc atcatgatgg gtcccaatac agtgggttcc    540

atcagcagag tgactcccat taccataggg ggtctcacca tggcagaccc caatatctcg    600

gtgagaattt atcccactat tcctctggcg tgccccacca cggtgaggct tcccaccatg    660

gtgggtccta cctcccccat ggacccaatc cctacagtga gtccttccac cacagcgagg    720

cttcccacct tagcgggctc caacacgatg agtcccagca tcaccaagtc ccccaccgtg    780

gctggcccca ccatcaccaa gtccaccacc atggcaggtc ccgtcatcat gaagcccacc    840

agcatggaaa gtctcctcat cacggagaga ccatttcccc tcattcctct gtggggtcct    900

accagcgtgg gatatctgac tatcacagcg agtaccacca aggtgatcac caccccagtg    960

agtaccacca tggcgaccat ccccaccaca cacagcacca ctaccaccag acccaccggc   1020

accgagacta ccatcagcac caagaccacc acggcgcgta tcattccagt tacctccatg   1080

gcgactacgt ccagagcact tcccaactct ctatcccaca cacatcccgg agcctgattc   1140

acgatgcccc cggccctgct gcttctcgta caggagtctt cccctatcac atagcacacc   1200

cacggggctc ggctcacagc atgactcggt cctccagcac aatccgctca cgtgtcaccc   1260

agatgtccaa aaaagtccat acccaggata tctccaccaa acattcagaa gactggggca   1320

aagaagaagg gcaatttcag aaacgcaaaa ccggccggct ccagcggacc cgcaagaagg   1380

gacactctac caatctcttc cagtggctgt gggaaaagct aaccttcctc attcagggct   1440

tccgggaaat gatccggaac ctgacccaat ccttggcctt tgaaactttc atcttcttcg   1500

ttgtctgcct caacaccgtc atgctggtgg cccagacctt cgctgaagtc gagatccggg   1560

gcgagtggta cttcatggcc ttggactcca tattcttctg catctacgtg gtggaagccc   1620

tgctcaagat catcgccctg ggcctctcgt acttctttga cttctggaac aatttggact   1680

tcttcattat ggccatggcc gtgctggact tcttgctgat gcagacccac tccttcgcca   1740

tctaccacca aagcctcttc cggatcctca aggtcttcaa gagcttgcgg gccctgaggg   1800

caatccgggt cctgcggagg ctcagcttcc tgaccagcgt ccaggaagtg acagggaccc   1860

tgggccagtc cttgccgtcc atcgcagcca tcctcatcct catgtttacc tgcctcttcc   1920

tcttctccgc ggtcctccgg gcactgttcc gcaaatctga ccccaagcgc ttccagaaca   1980

tcttcaccac catcttcacc ctcttcacct tgctcacgct ggatgactgg tccctcatct   2040

acatggacag ccgtgcccag ggcgcctggt acatcattcc catcctcata atttacatca   2100

tcatccagta cttcatcttc ctcaacctgg tgattactgt cctggtggat agcttccaga   2160

cggcgctgtt caaaggcctt gagaaagcga agcaggagag ggccgcccgg atccaagaga   2220

agctgctgga agactcactg acggagctca gagctgcaga gcccaaagag gtggcgagtg   2280

aaggcaccat gctgaagcgg ctcatcgaga aaaagtttgg gaccatgact gagaagcagc   2340

aggagctcct gttccattac ctgcagctgg tggcaagcgt ggagcaggag cagcagaagt   2400

tccgctccca ggcagccgtc atcgatgaga ttgtggacac cacatttgag gctggagaag   2460

aggacttcag gaattgaccc caggaggaca ccagatacag acttcagccc ctggcagtct   2520

gcccacctgg gtgcactggg acgggtcccc agatctgctg gaatgattgt ccgggccctg   2580

cagagcaggg gccccaacag agtttttaaa ccccaaaaaa aaaaaaaaaa              2630


<210>  2683
<211>  780
<212>  PRT
<213>  Homosapiens

<400>  2683

Met Asp Gln Asn Ser Val Pro Glu Lys Ala Gln Asn Glu Ala Asp Thr 
1               5                   10                  15      


Asn Asn Ala Asp Arg Phe Phe Arg Ser His Ser Ser Pro Pro His His 
            20                  25                  30          


Arg Pro Gly His Ser Arg Ala Leu His His Tyr Glu Leu His His His 
        35                  40                  45              


Gly Val Pro His Gln Arg Gly Glu Ser His His Pro Pro Glu Phe Gln 
    50                  55                  60                  


Asp Phe His Asp Gln Ala Leu Ser Ser His Val His Gln Ser His His 
65                  70                  75                  80  


His Ser Glu Ala Arg Asn His Gly Arg Ala His Gly Pro Thr Gly Phe 
                85                  90                  95      


Gly Leu Ala Pro Ser Gln Gly Ala Val Pro Ser His Arg Ser Tyr Gly 
            100                 105                 110         


Glu Asp Tyr His Asp Glu Leu Gln Arg Asp Gly Arg Arg His His Asp 
        115                 120                 125             


Gly Ser Gln Tyr Ser Gly Phe His Gln Gln Ser Asp Ser His Tyr His 
    130                 135                 140                 


Arg Gly Ser His His Gly Arg Pro Gln Tyr Leu Gly Glu Asn Leu Ser 
145                 150                 155                 160 


His Tyr Ser Ser Gly Val Pro His His Gly Glu Ala Ser His His Gly 
                165                 170                 175     


Gly Ser Tyr Leu Pro His Gly Pro Asn Pro Tyr Ser Glu Ser Phe His 
            180                 185                 190         


His Ser Glu Ala Ser His Leu Ser Gly Leu Gln His Asp Glu Ser Gln 
        195                 200                 205             


His His Gln Val Pro His Arg Gly Trp Pro His His His Gln Val His 
    210                 215                 220                 


His His Gly Arg Ser Arg His His Glu Ala His Gln His Gly Lys Ser 
225                 230                 235                 240 


Pro His His Gly Glu Thr Ile Ser Pro His Ser Ser Val Gly Ser Tyr 
                245                 250                 255     


Gln Arg Gly Ile Ser Asp Tyr His Ser Glu Tyr His Gln Gly Asp His 
            260                 265                 270         


His Pro Ser Glu Tyr His His Gly Asp His Pro His His Thr Gln His 
        275                 280                 285             


His Tyr His Gln Thr His Arg His Arg Asp Tyr His Gln His Gln Asp 
    290                 295                 300                 


His His Gly Ala Tyr His Ser Ser Tyr Leu His Gly Asp Tyr Val Gln 
305                 310                 315                 320 


Ser Thr Ser Gln Leu Ser Ile Pro His Thr Ser Arg Ser Leu Ile His 
                325                 330                 335     


Asp Ala Pro Gly Pro Ala Ala Ser Arg Thr Gly Val Phe Pro Tyr His 
            340                 345                 350         


Ile Ala His Pro Arg Gly Ser Ala His Ser Met Thr Arg Ser Ser Ser 
        355                 360                 365             


Thr Ile Arg Ser Arg Val Thr Gln Met Ser Lys Lys Val His Thr Gln 
    370                 375                 380                 


Asp Ile Ser Thr Lys His Ser Glu Asp Trp Gly Lys Glu Glu Gly Gln 
385                 390                 395                 400 


Phe Gln Lys Arg Lys Thr Gly Arg Leu Gln Arg Thr Arg Lys Lys Gly 
                405                 410                 415     


His Ser Thr Asn Leu Phe Gln Trp Leu Trp Glu Lys Leu Thr Phe Leu 
            420                 425                 430         


Ile Gln Gly Phe Arg Glu Met Ile Arg Asn Leu Thr Gln Ser Leu Ala 
        435                 440                 445             


Phe Glu Thr Phe Ile Phe Phe Val Val Cys Leu Asn Thr Val Met Leu 
    450                 455                 460                 


Val Ala Gln Thr Phe Ala Glu Val Glu Ile Arg Gly Glu Trp Tyr Phe 
465                 470                 475                 480 


Met Ala Leu Asp Ser Ile Phe Phe Cys Ile Tyr Val Val Glu Ala Leu 
                485                 490                 495     


Leu Lys Ile Ile Ala Leu Gly Leu Ser Tyr Phe Phe Asp Phe Trp Asn 
            500                 505                 510         


Asn Leu Asp Phe Phe Ile Met Ala Met Ala Val Leu Asp Phe Leu Leu 
        515                 520                 525             


Met Gln Thr His Ser Phe Ala Ile Tyr His Gln Ser Leu Phe Arg Ile 
    530                 535                 540                 


Leu Lys Val Phe Lys Ser Leu Arg Ala Leu Arg Ala Ile Arg Val Leu 
545                 550                 555                 560 


Arg Arg Leu Ser Phe Leu Thr Ser Val Gln Glu Val Thr Gly Thr Leu 
                565                 570                 575     


Gly Gln Ser Leu Pro Ser Ile Ala Ala Ile Leu Ile Leu Met Phe Thr 
            580                 585                 590         


Cys Leu Phe Leu Phe Ser Ala Val Leu Arg Ala Leu Phe Arg Lys Ser 
        595                 600                 605             


Asp Pro Lys Arg Phe Gln Asn Ile Phe Thr Thr Ile Phe Thr Leu Phe 
    610                 615                 620                 


Thr Leu Leu Thr Leu Asp Asp Trp Ser Leu Ile Tyr Met Asp Ser Arg 
625                 630                 635                 640 


Ala Gln Gly Ala Trp Tyr Ile Ile Pro Ile Leu Ile Ile Tyr Ile Ile 
                645                 650                 655     


Ile Gln Tyr Phe Ile Phe Leu Asn Leu Val Ile Thr Val Leu Val Asp 
            660                 665                 670         


Ser Phe Gln Thr Ala Leu Phe Lys Gly Leu Glu Lys Ala Lys Gln Glu 
        675                 680                 685             


Arg Ala Ala Arg Ile Gln Glu Lys Leu Leu Glu Asp Ser Leu Thr Glu 
    690                 695                 700                 


Leu Arg Ala Ala Glu Pro Lys Glu Val Ala Ser Glu Gly Thr Met Leu 
705                 710                 715                 720 


Lys Arg Leu Ile Glu Lys Lys Phe Gly Thr Met Thr Glu Lys Gln Gln 
                725                 730                 735     


Glu Leu Leu Phe His Tyr Leu Gln Leu Val Ala Ser Val Glu Gln Glu 
            740                 745                 750         


Gln Gln Lys Phe Arg Ser Gln Ala Ala Val Ile Asp Glu Ile Val Asp 
        755                 760                 765             


Thr Thr Phe Glu Ala Gly Glu Glu Asp Phe Arg Asn 
    770                 775                 780 


<210>  2684
<211>  2103
<212>  DNA
<213>  Homosapiens

<400>  2684
ctagcggacg ctgccacctg atcccatcca ggcgctgaga ggcaagccac cggcactcgg     60

cgcgcagggc cccgggcacc ctcggacccc gtgcggattt cgagacaagg gtccagagat    120

agcggcggcc gcccccaacc cgggccagag gcagagccca ggcgtgcggt gcttctcggg    180

aacactggcc ctgctaccag agccgcagga tcccccatga gtgcctgtga agggagtcct    240

ggatagtgag gccctggctg gtccaggggt gggtactccg ccatgccacc catcctccag    300

cgcctgcagc aggccaccaa gatgatgagc cgccggaaaa tcctgctgct ggtgctaggg    360

tgcagcaccg taagccttct catccaccag ggggcgcagc tcagctggta ccccaagctg    420

ttccccttga gctgccctcc tctgcggaac tcgccgccgc gccccaagca catgactgtg    480

gccttcctga agactcacaa gacggcaggc acgacggtgc agaacatcct gtttcgcttt    540

gccgagcgcc acaacctgac ggtggccctg ccgcacccga gctgcgagca ccagttctgc    600

tacccccgca acttctcggc gcacttcgtg cacccggcca cgcggccgcc gcacgtgctg    660

gccagccacc tgcgcttcga ccgtgcggag ctggagcgcc tcatgccgcc cagcaccgtc    720

tatgtcacca tcctgcgcga gccggccgcc atgttcgagt cgctcttcag ctactacaac    780

cagtactgcc cggccttccg gcgcgtgccc aacgcctcgc tcgaggcctt cctgcgcgcg    840

cccgaggcat actaccgcgc tggcgagcac ttcgccatgt tcgcacacaa cacgctggcc    900

tacgacctgg gcggcgacaa tgagcgcagc ccgcgcgacg acgccgccta cctggcgggc    960

ctcatccgcc aggtggagga ggttttctcg ctcgtcatga tcgccgagta cttcgacgag   1020

tcgctagtgc tgctgcggcg cctactggcc tgggacctgg acgacgtgct ctacgccaag   1080

ctcaacgcgc gcgccgccag ctcgcgcctg gccgccatcc ccgcggcgct ggcgcgggcg   1140

gcgcgcacct ggaacgccct ggacgccggc ctctacgacc acttcaacgc caccttctgg   1200

cgccacgtgg cgcgcgcggg ccgcgcgtgc gtggagcgcg aggcgcgcga gctgcgcgag   1260

gcccgccagc gcctactgcg gcgctgcttc ggggacgagc cactgctgcg gcctgccgcg   1320

cagatccgca ccaagcagct gcagccatgg cagcccagcc gcaaggtgga cattatgggc   1380

tatgacctgc ccggcggcgg cgccggcccg gccaccgagg cctgcctcaa gctggccatg   1440

cccgaggtcc agtactcgaa ctacctgttg cgcaagcaga agcgccgggg cggtgcgcgg   1500

gctcggcccg agcccgtcct ggacaatccc ccgcctcggc ccatccgagt gctgcctcgc   1560

ggccctcaag gtccctgagc tccgcaggcc tccaggagta tgggtcctgc cctgccctcc   1620

caggagtcca gccaggggct gcctccatgt cctgccccca tgagagccct ttcttttcaa   1680

tgggcttgag tccctcgctg aactttgggg tacgcctccc tatctgagcc cccgctcccg   1740

atcgtgggct gaaccttgcc ttcgggcacg gcgctgatag gctggatcca gcgctgggcc   1800

accctctcct tcccagctgg ttggtgattt tgacaagagg cctgagggct gtccagaact   1860

gctcaccctg cctttttctg ggggctgagc ccccacaacc tgtcttttcc aagtggataa   1920

gcccaggccc catggagaga ggctcagccc tagggaaagg ctgctcttgc tctccctccc   1980

agggcttgag gctccctata cttttctgtc ttccaggttc taccctcccc acagacctaa   2040

gctgctccca gtctcccaga accaagagtt cttgggttgg gatttttgtt tggttggttt   2100

ttc                                                                 2103


<210>  2685
<211>  431
<212>  PRT
<213>  Homosapiens

<400>  2685

Met Pro Pro Ile Leu Gln Arg Leu Gln Gln Ala Thr Lys Met Met Ser 
1               5                   10                  15      


Arg Arg Lys Ile Leu Leu Leu Val Leu Gly Cys Ser Thr Val Ser Leu 
            20                  25                  30          


Leu Ile His Gln Gly Ala Gln Leu Ser Trp Tyr Pro Lys Leu Phe Pro 
        35                  40                  45              


Leu Ser Cys Pro Pro Leu Arg Asn Ser Pro Pro Arg Pro Lys His Met 
    50                  55                  60                  


Thr Val Ala Phe Leu Lys Thr His Lys Thr Ala Gly Thr Thr Val Gln 
65                  70                  75                  80  


Asn Ile Leu Phe Arg Phe Ala Glu Arg His Asn Leu Thr Val Ala Leu 
                85                  90                  95      


Pro His Pro Ser Cys Glu His Gln Phe Cys Tyr Pro Arg Asn Phe Ser 
            100                 105                 110         


Ala His Phe Val His Pro Ala Thr Arg Pro Pro His Val Leu Ala Ser 
        115                 120                 125             


His Leu Arg Phe Asp Arg Ala Glu Leu Glu Arg Leu Met Pro Pro Ser 
    130                 135                 140                 


Thr Val Tyr Val Thr Ile Leu Arg Glu Pro Ala Ala Met Phe Glu Ser 
145                 150                 155                 160 


Leu Phe Ser Tyr Tyr Asn Gln Tyr Cys Pro Ala Phe Arg Arg Val Pro 
                165                 170                 175     


Asn Ala Ser Leu Glu Ala Phe Leu Arg Ala Pro Glu Ala Tyr Tyr Arg 
            180                 185                 190         


Ala Gly Glu His Phe Ala Met Phe Ala His Asn Thr Leu Ala Tyr Asp 
        195                 200                 205             


Leu Gly Gly Asp Asn Glu Arg Ser Pro Arg Asp Asp Ala Ala Tyr Leu 
    210                 215                 220                 


Ala Gly Leu Ile Arg Gln Val Glu Glu Val Phe Ser Leu Val Met Ile 
225                 230                 235                 240 


Ala Glu Tyr Phe Asp Glu Ser Leu Val Leu Leu Arg Arg Leu Leu Ala 
                245                 250                 255     


Trp Asp Leu Asp Asp Val Leu Tyr Ala Lys Leu Asn Ala Arg Ala Ala 
            260                 265                 270         


Ser Ser Arg Leu Ala Ala Ile Pro Ala Ala Leu Ala Arg Ala Ala Arg 
        275                 280                 285             


Thr Trp Asn Ala Leu Asp Ala Gly Leu Tyr Asp His Phe Asn Ala Thr 
    290                 295                 300                 


Phe Trp Arg His Val Ala Arg Ala Gly Arg Ala Cys Val Glu Arg Glu 
305                 310                 315                 320 


Ala Arg Glu Leu Arg Glu Ala Arg Gln Arg Leu Leu Arg Arg Cys Phe 
                325                 330                 335     


Gly Asp Glu Pro Leu Leu Arg Pro Ala Ala Gln Ile Arg Thr Lys Gln 
            340                 345                 350         


Leu Gln Pro Trp Gln Pro Ser Arg Lys Val Asp Ile Met Gly Tyr Asp 
        355                 360                 365             


Leu Pro Gly Gly Gly Ala Gly Pro Ala Thr Glu Ala Cys Leu Lys Leu 
    370                 375                 380                 


Ala Met Pro Glu Val Gln Tyr Ser Asn Tyr Leu Leu Arg Lys Gln Lys 
385                 390                 395                 400 


Arg Arg Gly Gly Ala Arg Ala Arg Pro Glu Pro Val Leu Asp Asn Pro 
                405                 410                 415     


Pro Pro Arg Pro Ile Arg Val Leu Pro Arg Gly Pro Gln Gly Pro 
            420                 425                 430     


<210>  2686
<211>  2902
<212>  DNA
<213>  Homosapiens

<400>  2686
cccagcttcc gggttggtcg cgcgccttcc tgcggctaag atggcgacgg agcatcccga     60

gcctcccaaa gcagaattgc agctgccgcc gccgccacct ccaggccact atggcgcctg    120

ggctgcccag gagcttcagg ccaagttggc agagatcgga gctccgatcc agggtaatcg    180

cgaggagctg gtggagcggc tgcagagcta cacccgccag actggcatcg tgctgaatcg    240

gccggttttg agaggggaag atggggacaa agccgctcca cctcccatgt cggcacagct    300

ccctggaatt cccatgccac caccaccttt gggactcccc cctctgcagc ctcctccgcc    360

acccccacca cctccaccag gccttggcct tggctttcct atggcccacc caccaaattt    420

ggggcccccg cctcctctcc gtgtgggtga gccagtggca ctgtcagagg aggagcggct    480

gaagttggct cagcagcagg cggcattgct gatgcagcag gaggagcgtg ccaagcagca    540

gggagatcat tcgctgaagg aacatgagct cttggagcag cagaagcggg cagctgtgtt    600

actggagcag gaacgacagc aggagattgc caagatgggc accccagtcc ctcggccccc    660

acaagacatg ggccagattg gtgtgcgcac tcctctgggt cctcgagtag ctgctccagt    720

gggcccagtg ggccccactc ctacagtttt gcccatggga gcccctgttc cccggcctcg    780

tggtccccca ccgccccctg gagatgagaa cagagagatg gatgacccct ctgtgggccc    840

caagatcccc caggctttgg agaagatcct gcagctgaag gagagccgcc aggaagagat    900

gaattctcag caggaggaag aggaaatgga aacagatgct cgctcgtccc tgggccagtc    960

agcgtcagag actgaggagg acacagtgtc cgtatctaaa aaggagaaaa accggaagcg   1020

taggaaccga aagaagaaga aaaagcccca gcgggtgcga ggggtgtcct ctgagagctc   1080

tggggaccgg gagaaagact caacccggtc ccgtggctct gattccccag cagctgatgt   1140

tgagattgag tatgtgactg aagaacctga aatttacgag cccaacttta tcttctttaa   1200

gaggatcttt gaggctttta agctcactga tgatgtgaag aaggagaaag agaaggagcc   1260

agagaaactt gacaaactgg agaactctgc agcccccaag aagaagggat ttgaagagga   1320

gcacaaggac agtgatgatg acagcagtga tgacgagcag gaaaagaagc cagaagcccc   1380

caagctgtcc aagaagaagt tgcgccgaat gaaccgcttc actgtggctg aactcaagca   1440

gctggtggct cggcccgatg tcgtggagat gcacgatgtg acagcgcagg accctaagct   1500

cttggttcac ctcaaggcca ctcggaactc tgtgcctgtg ccacgccact ggtgttttaa   1560

gcgcaaatac ctgcagggca aacggggcat tgagaagccc cccttcgagc tgccagactt   1620

catcaaacgc acaggcatcc aggagatgcg agaggccctg caggagaagg aagaacagaa   1680

gaccatgaag tcaaaaatgc gagagaaagt tcggcctaag atgggcaaaa ttgacatcga   1740

ctaccagaaa ctgcatgatg ccttcttcaa gtggcagacc aagccaaagc tgaccatcca   1800

tggggacctg tactatgagg ggaaggagtt cgagacacga ctgaaggaga agaagccagg   1860

agatctgtct gatgagctaa ggatttcctt ggggatgcca gtaggaccaa atgcccacaa   1920

ggtccctccc ccatggctga ttgccatgca gcgatatgga ccacccccat cgtatcccaa   1980

cctgaaaatc cctgggctga actcgcccat ccctgagagc tgttcctttg ggtaccatgc   2040

tggtggctgg ggcaaacctc cagtggatga gactgggaaa ccgctctatg gggacgtgtt   2100

tggaaccaat gctgctgaat ttcagaccaa gactgaggaa gaagagattg atcggacccc   2160

ttggggggaa ctggaaccat ctgatgaaga atcctcagaa gaagaggaag aggaagaaag   2220

tgatgaagac aaaccagatg agacaggctt tattacccct gcagacagtg gccttatcac   2280

tcctggaggc ttttcatcag tgcctgctgg aatggagacc cctgaactca ttgagctgag   2340

gaagaagaag attgaggagg cgatggacgg aagtgagaca cctcagctct tcactgtgtt   2400

gccagagaag agaacagcca ctgttggagg ggccatgatg ggatcaaccc acatttatga   2460

catgtccacg gttatgagcc ggaagggccc ggctcctgag ctgcaaggtg tggaagtggc   2520

gctggcgcct gaagagttgg agctggatcc tatggccatg acccagaagt atgaggagca   2580

tgtgcgggag cagcaggctc aagtagagaa ggaggacttc agtgacatgg tggctgagca   2640

cgctgccaaa cagaagcaaa aaaaacggaa agctcagccc caggacagcc gtgggggcag   2700

caagaaatat aaggagttca agttttaggt cccctcacac tagccctttt tttggcccta   2760

cgtctggatg cctgggcttc acacaagaac cacctctccc gcagttccca aggacttgtc   2820

atttcatgtt cttattttag acctgttttg taaataaagc tgtttcccaa ggaaagagat   2880

gaatatttaa cactaaaaaa aa                                            2902


<210>  2687
<211>  895
<212>  PRT
<213>  Homosapiens

<400>  2687

Met Ala Thr Glu His Pro Glu Pro Pro Lys Ala Glu Leu Gln Leu Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Gly His Tyr Gly Ala Trp Ala Ala Gln Glu Leu 
            20                  25                  30          


Gln Ala Lys Leu Ala Glu Ile Gly Ala Pro Ile Gln Gly Asn Arg Glu 
        35                  40                  45              


Glu Leu Val Glu Arg Leu Gln Ser Tyr Thr Arg Gln Thr Gly Ile Val 
    50                  55                  60                  


Leu Asn Arg Pro Val Leu Arg Gly Glu Asp Gly Asp Lys Ala Ala Pro 
65                  70                  75                  80  


Pro Pro Met Ser Ala Gln Leu Pro Gly Ile Pro Met Pro Pro Pro Pro 
                85                  90                  95      


Leu Gly Leu Pro Pro Leu Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            100                 105                 110         


Pro Gly Leu Gly Leu Gly Phe Pro Met Ala His Pro Pro Asn Leu Gly 
        115                 120                 125             


Pro Pro Pro Pro Leu Arg Val Gly Glu Pro Val Ala Leu Ser Glu Glu 
    130                 135                 140                 


Glu Arg Leu Lys Leu Ala Gln Gln Gln Ala Ala Leu Leu Met Gln Gln 
145                 150                 155                 160 


Glu Glu Arg Ala Lys Gln Gln Gly Asp His Ser Leu Lys Glu His Glu 
                165                 170                 175     


Leu Leu Glu Gln Gln Lys Arg Ala Ala Val Leu Leu Glu Gln Glu Arg 
            180                 185                 190         


Gln Gln Glu Ile Ala Lys Met Gly Thr Pro Val Pro Arg Pro Pro Gln 
        195                 200                 205             


Asp Met Gly Gln Ile Gly Val Arg Thr Pro Leu Gly Pro Arg Val Ala 
    210                 215                 220                 


Ala Pro Val Gly Pro Val Gly Pro Thr Pro Thr Val Leu Pro Met Gly 
225                 230                 235                 240 


Ala Pro Val Pro Arg Pro Arg Gly Pro Pro Pro Pro Pro Gly Asp Glu 
                245                 250                 255     


Asn Arg Glu Met Asp Asp Pro Ser Val Gly Pro Lys Ile Pro Gln Ala 
            260                 265                 270         


Leu Glu Lys Ile Leu Gln Leu Lys Glu Ser Arg Gln Glu Glu Met Asn 
        275                 280                 285             


Ser Gln Gln Glu Glu Glu Glu Met Glu Thr Asp Ala Arg Ser Ser Leu 
    290                 295                 300                 


Gly Gln Ser Ala Ser Glu Thr Glu Glu Asp Thr Val Ser Val Ser Lys 
305                 310                 315                 320 


Lys Glu Lys Asn Arg Lys Arg Arg Asn Arg Lys Lys Lys Lys Lys Pro 
                325                 330                 335     


Gln Arg Val Arg Gly Val Ser Ser Glu Ser Ser Gly Asp Arg Glu Lys 
            340                 345                 350         


Asp Ser Thr Arg Ser Arg Gly Ser Asp Ser Pro Ala Ala Asp Val Glu 
        355                 360                 365             


Ile Glu Tyr Val Thr Glu Glu Pro Glu Ile Tyr Glu Pro Asn Phe Ile 
    370                 375                 380                 


Phe Phe Lys Arg Ile Phe Glu Ala Phe Lys Leu Thr Asp Asp Val Lys 
385                 390                 395                 400 


Lys Glu Lys Glu Lys Glu Pro Glu Lys Leu Asp Lys Leu Glu Asn Ser 
                405                 410                 415     


Ala Ala Pro Lys Lys Lys Gly Phe Glu Glu Glu His Lys Asp Ser Asp 
            420                 425                 430         


Asp Asp Ser Ser Asp Asp Glu Gln Glu Lys Lys Pro Glu Ala Pro Lys 
        435                 440                 445             


Leu Ser Lys Lys Lys Leu Arg Arg Met Asn Arg Phe Thr Val Ala Glu 
    450                 455                 460                 


Leu Lys Gln Leu Val Ala Arg Pro Asp Val Val Glu Met His Asp Val 
465                 470                 475                 480 


Thr Ala Gln Asp Pro Lys Leu Leu Val His Leu Lys Ala Thr Arg Asn 
                485                 490                 495     


Ser Val Pro Val Pro Arg His Trp Cys Phe Lys Arg Lys Tyr Leu Gln 
            500                 505                 510         


Gly Lys Arg Gly Ile Glu Lys Pro Pro Phe Glu Leu Pro Asp Phe Ile 
        515                 520                 525             


Lys Arg Thr Gly Ile Gln Glu Met Arg Glu Ala Leu Gln Glu Lys Glu 
    530                 535                 540                 


Glu Gln Lys Thr Met Lys Ser Lys Met Arg Glu Lys Val Arg Pro Lys 
545                 550                 555                 560 


Met Gly Lys Ile Asp Ile Asp Tyr Gln Lys Leu His Asp Ala Phe Phe 
                565                 570                 575     


Lys Trp Gln Thr Lys Pro Lys Leu Thr Ile His Gly Asp Leu Tyr Tyr 
            580                 585                 590         


Glu Gly Lys Glu Phe Glu Thr Arg Leu Lys Glu Lys Lys Pro Gly Asp 
        595                 600                 605             


Leu Ser Asp Glu Leu Arg Ile Ser Leu Gly Met Pro Val Gly Pro Asn 
    610                 615                 620                 


Ala His Lys Val Pro Pro Pro Trp Leu Ile Ala Met Gln Arg Tyr Gly 
625                 630                 635                 640 


Pro Pro Pro Ser Tyr Pro Asn Leu Lys Ile Pro Gly Leu Asn Ser Pro 
                645                 650                 655     


Ile Pro Glu Ser Cys Ser Phe Gly Tyr His Ala Gly Gly Trp Gly Lys 
            660                 665                 670         


Pro Pro Val Asp Glu Thr Gly Lys Pro Leu Tyr Gly Asp Val Phe Gly 
        675                 680                 685             


Thr Asn Ala Ala Glu Phe Gln Thr Lys Thr Glu Glu Glu Glu Ile Asp 
    690                 695                 700                 


Arg Thr Pro Trp Gly Glu Leu Glu Pro Ser Asp Glu Glu Ser Ser Glu 
705                 710                 715                 720 


Glu Glu Glu Glu Glu Glu Ser Asp Glu Asp Lys Pro Asp Glu Thr Gly 
                725                 730                 735     


Phe Ile Thr Pro Ala Asp Ser Gly Leu Ile Thr Pro Gly Gly Phe Ser 
            740                 745                 750         


Ser Val Pro Ala Gly Met Glu Thr Pro Glu Leu Ile Glu Leu Arg Lys 
        755                 760                 765             


Lys Lys Ile Glu Glu Ala Met Asp Gly Ser Glu Thr Pro Gln Leu Phe 
    770                 775                 780                 


Thr Val Leu Pro Glu Lys Arg Thr Ala Thr Val Gly Gly Ala Met Met 
785                 790                 795                 800 


Gly Ser Thr His Ile Tyr Asp Met Ser Thr Val Met Ser Arg Lys Gly 
                805                 810                 815     


Pro Ala Pro Glu Leu Gln Gly Val Glu Val Ala Leu Ala Pro Glu Glu 
            820                 825                 830         


Leu Glu Leu Asp Pro Met Ala Met Thr Gln Lys Tyr Glu Glu His Val 
        835                 840                 845             


Arg Glu Gln Gln Ala Gln Val Glu Lys Glu Asp Phe Ser Asp Met Val 
    850                 855                 860                 


Ala Glu His Ala Ala Lys Gln Lys Gln Lys Lys Arg Lys Ala Gln Pro 
865                 870                 875                 880 


Gln Asp Ser Arg Gly Gly Ser Lys Lys Tyr Lys Glu Phe Lys Phe 
                885                 890                 895 


<210>  2688
<211>  4488
<212>  DNA
<213>  Homosapiens

<400>  2688
gcagctcgct ggctgctcgc gctcgggcag gcgggctgag gaggctgccg cgcccccgcc     60

gccgccgccg cgggggaagc ctgggagcca gatcggcgtc gcctcggcct ccgtaacccc    120

cgcctagccg ggccatggcg gaacgcggag gggcgggcgg tggtcccgga ggcgccgggg    180

gcggcagcgg ccagcgggga tccggggtcg cccagtcccc tcagcagccg ccgccgcagc    240

agcagcagca gcagccgccg cagcagccga cgccccccaa gctggcccag gccacctcgt    300

cgtcctcgtc cacctcggcg gcggctgcct cctcctcgtc ctcgtctacc tccacctcca    360

tggccgtggc ggtggcctcg ggctccgcgc ctcccggtgg cccggggcca ggccgcaccc    420

ccgccccggt gcagatgaac ctgtacgcca cctgggaggt ggaccggagc tcgtccagct    480

gcgtgcctag gctattcagc ttgaccctga agaaactcgt catgctaaaa gaaatggaca    540

aagatcttaa ctcagtggtc atcgctgtga agctgcaggg ttcaaaaaga attcttcgct    600

ccaacgagat cgtccttcca gctagtggac tggtggaaac agagctccaa ttaaccttct    660

cccttcagta ccctcatttc cttaagcgag atgccaacaa gctgcagatc atgctgcaaa    720

ggagaaaacg ttacaagaat cggaccatct tgggctataa gaccttggcc gtgggactca    780

tcaacatggc agaggtgatg cagcatccta atgaaggcgc actggtgctt ggcctacaca    840

gcaacgtgaa ggatgtctct gtgcctgtgg cagaaataaa gatctactcc ctgtccagcc    900

aacccattga ccatgaagga atcaaatcca agctttctga tcgttctcct gatattgaca    960

attattctga ggaagaggaa gagagtttct catcagaaca ggaaggcagt gatgatccat   1020

tgcatgggca ggacttgttc tacgaagacg aagatctccg gaaagtgaag aagacccgga   1080

ggaaactaac ctcaacctct gccatcacaa ggcaacctaa catcaaacag aagtttgtgg   1140

ccctcctgaa gcggtttaaa gtttcagatg aggtgggctt tgggctggag catgtgtccc   1200

gcgagcagat ccgggaagtg gaagaggact tggatgaatt gtatgacagt ctggagatgt   1260

acaaccccag cgacagtggc cctgagatgg aggagacaga aagcatcctc agcacgccaa   1320

agcccaagct caagcctttc tttgagggga tgtcgcagtc cagctcccag acggagattg   1380

gcagcctcaa cagcaaaggc agcctcggaa aagacaccac cagccctatg gaattggctg   1440

ctctagaaaa aattaaatct acttggatta aaaaccaaga tgacagcttg actgaaacag   1500

acactctgga aatcactgac caggacatgt ttggagatgc cagcacgagt ctggttgtgc   1560

cggagaaagt caaaactccc atgaagtcca gtaaaacgga tctccagggc tctgcctccc   1620

ccagcaaagt ggagggggtg cacacacccc ggcagaagag gagcacgccc ctgaaggagc   1680

ggcagctctc caagccccta agtgagagga ccaacagttc cgacagcgag cgctccccag   1740

atctgggcca cagcacgcag attccaagaa aggtggtgta tgaccagctc aatcagatcc   1800

tggtgtcaga tgcagccctc ccagaaaatg tcattctggt gaacaccact gactggcagg   1860

gccagtatgt ggctgagctg ctccaggacc agcggaagcc tgtggtgtgc acctgctcca   1920

ccgtggaggt ccaggccgtg ctgtccgccc tgctcacccg gatccagcgc tactgcaact   1980

gcaactcttc catgccgagg ccagtgaagg tggctgctgt gggaggccag agctacctga   2040

gctccatcct caggttcttt gtcaagtccc tggccaacaa gacctccgac tggcttggct   2100

acatgcgctt cctcatcatc cccctcggtt ctcaccctgt ggccaaatac ttggggtcag   2160

tcgacagtaa atacagtagt tccttcctgg attctggttg gagagatctg ttcagtcgct   2220

cggagccacc agtgtcagag caactggacg tggcagggcg ggtgatgcag tacgtcaacg   2280

gggcagccac gacacaccag cttcccgtgg ccgaagccat gctgacttgc cggcataagt   2340

tccctgatga agactcctat cagaagttta ttcccttcat tggcgtggtg aaggtgggtc   2400

tggttgaaga ctctccctcc acagcaggcg atggggacga ttctcctgtg gtcagcctta   2460

ctgtgccctc cacatcacca ccctccagct cgggcctgag ccgagacgcc acggccaccc   2520

ctccctcctc cccatctatg agcagcgccc tggccatcgt ggggagccct aatagcccat   2580

atggggacgt gattggcctc caggtggact actggctggg ccaccccggg gagcggagga   2640

gggaaggcga caagagggac gccagctcga agaacaccct caagagtgtc ttccgctcag   2700

tgcaggtgtc ccgcctgccc catagtgggg aggcccagct ttctggcacc atggccatga   2760

ctgtggtcac caaagaaaag aacaagaaag ttcccaccat cttcctgagc aagaaacccc   2820

gagaaaagga ggtggattct aagagccagg tcattgaagg catcagccgc ctcatctgct   2880

cagccaagca gcagcagact atgctgagag tgtccatcga tggggtcgag tggagtgaca   2940

tcaagttctt ccagctggca gcccagtggc ccacccatgt caagcacttt ccagtgggac   3000

tcttcagtgg cagcaaggcc acctgaggcc ctgtctccca gccactttcc ctcctggcac   3060

tgccaccagc ctcaccgcct gcgggcaggg ggaggccagc aggcccgggc ccagcacccc   3120

ttccctggca ccagggtctg cctctcactc gcccaggtcc cgaaggacac tgccacaggg   3180

acgccttccc tcccctcccc tccagcccac ccctgcacag cccctcctcc ttcccgcttt   3240

tccccttctc cctcctgctc caggcccaag gcgtgttggt tttgccttct ggtgcccata   3300

gtcccctgga ctgagtcccc caggccttcc ttcacccgac ttccaaactc ttccttgtgg   3360

tatcagtttc cttctcggaa atgagaaagc tggaatcctg gtccccagca ggagagccta   3420

gtcctccccc agcccctcca gccaccaggg tgtcctctag gatgcagctg ccagatccac   3480

tcactctgct gcctccagca ggacccaagg ccactttcaa ctcttatggg gttctccacc   3540

tgccccagag cttctcaagg gagggtaagg gggcaccctg agcccacagg acccctactt   3600

cacagctcac aggggcagga ggcagctccc ctgcctccag gaccctgttg ctatggtgac   3660

acagcgtttc taggacagag gggcctccca gtctcccccc accacccgtg cacgacttcc   3720

tcaccacccc caggttccct gcagatgtcg tgtgtgtcct gagtgtttct ttggttcttt   3780

gcacgccaag tctcttggtt gtaccatgtg acacaccctg tgcactggtc gctgtcttcg   3840

tggcttccac ccttgttaat gatgctcctg cctctgcctc ccagcccctc acccagcaca   3900

gctctgcctg gacttggaga gatgggaggc agacccccac caccatacat gctgtctgtg   3960

gcccctcaga cattctgttt catctcccat tcatctccct cctcccaccg tgtcagtttt   4020

tctgcctttc cctgctctgt tcttccccct ccttaggccc cagcctgggc ccagacccat   4080

cctcccagcc aggtttccct ccagcaggct ccttccctcc ctgtcacctc cctctcacca   4140

acccggggtc tgagcccctc attcctgacc gtccgtgttc tcaggagtgg ttgaggacac   4200

agggccccag cccagccctc tgcacccccc agcccggcca tctgcgcccc acagcccctt   4260

tggagctttt ctcttgtcct ctcactcctt cccagaagtt tttgcacaga acttcatttt   4320

gaaagtgttt ttctcattct ccatacctcc cccaagctct cctccagccc ttcccagggc   4380

tcagccctgc tgtcctgagc gtctcctggg ccagagagag gagatggggg tgggagggac   4440

tgagttgatg ttgggttttt cattcaataa attggtgatt tcttaccg                4488


<210>  2689
<211>  963
<212>  PRT
<213>  Homosapiens

<400>  2689

Met Ala Glu Arg Gly Gly Ala Gly Gly Gly Pro Gly Gly Ala Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gln Arg Gly Ser Gly Val Ala Gln Ser Pro Gln Gln Pro 
            20                  25                  30          


Pro Pro Gln Gln Gln Gln Gln Gln Pro Pro Gln Gln Pro Thr Pro Pro 
        35                  40                  45              


Lys Leu Ala Gln Ala Thr Ser Ser Ser Ser Ser Thr Ser Ala Ala Ala 
    50                  55                  60                  


Ala Ser Ser Ser Ser Ser Ser Thr Ser Thr Ser Met Ala Val Ala Val 
65                  70                  75                  80  


Ala Ser Gly Ser Ala Pro Pro Gly Gly Pro Gly Pro Gly Arg Thr Pro 
                85                  90                  95      


Ala Pro Val Gln Met Asn Leu Tyr Ala Thr Trp Glu Val Asp Arg Ser 
            100                 105                 110         


Ser Ser Ser Cys Val Pro Arg Leu Phe Ser Leu Thr Leu Lys Lys Leu 
        115                 120                 125             


Val Met Leu Lys Glu Met Asp Lys Asp Leu Asn Ser Val Val Ile Ala 
    130                 135                 140                 


Val Lys Leu Gln Gly Ser Lys Arg Ile Leu Arg Ser Asn Glu Ile Val 
145                 150                 155                 160 


Leu Pro Ala Ser Gly Leu Val Glu Thr Glu Leu Gln Leu Thr Phe Ser 
                165                 170                 175     


Leu Gln Tyr Pro His Phe Leu Lys Arg Asp Ala Asn Lys Leu Gln Ile 
            180                 185                 190         


Met Leu Gln Arg Arg Lys Arg Tyr Lys Asn Arg Thr Ile Leu Gly Tyr 
        195                 200                 205             


Lys Thr Leu Ala Val Gly Leu Ile Asn Met Ala Glu Val Met Gln His 
    210                 215                 220                 


Pro Asn Glu Gly Ala Leu Val Leu Gly Leu His Ser Asn Val Lys Asp 
225                 230                 235                 240 


Val Ser Val Pro Val Ala Glu Ile Lys Ile Tyr Ser Leu Ser Ser Gln 
                245                 250                 255     


Pro Ile Asp His Glu Gly Ile Lys Ser Lys Leu Ser Asp Arg Ser Pro 
            260                 265                 270         


Asp Ile Asp Asn Tyr Ser Glu Glu Glu Glu Glu Ser Phe Ser Ser Glu 
        275                 280                 285             


Gln Glu Gly Ser Asp Asp Pro Leu His Gly Gln Asp Leu Phe Tyr Glu 
    290                 295                 300                 


Asp Glu Asp Leu Arg Lys Val Lys Lys Thr Arg Arg Lys Leu Thr Ser 
305                 310                 315                 320 


Thr Ser Ala Ile Thr Arg Gln Pro Asn Ile Lys Gln Lys Phe Val Ala 
                325                 330                 335     


Leu Leu Lys Arg Phe Lys Val Ser Asp Glu Val Gly Phe Gly Leu Glu 
            340                 345                 350         


His Val Ser Arg Glu Gln Ile Arg Glu Val Glu Glu Asp Leu Asp Glu 
        355                 360                 365             


Leu Tyr Asp Ser Leu Glu Met Tyr Asn Pro Ser Asp Ser Gly Pro Glu 
    370                 375                 380                 


Met Glu Glu Thr Glu Ser Ile Leu Ser Thr Pro Lys Pro Lys Leu Lys 
385                 390                 395                 400 


Pro Phe Phe Glu Gly Met Ser Gln Ser Ser Ser Gln Thr Glu Ile Gly 
                405                 410                 415     


Ser Leu Asn Ser Lys Gly Ser Leu Gly Lys Asp Thr Thr Ser Pro Met 
            420                 425                 430         


Glu Leu Ala Ala Leu Glu Lys Ile Lys Ser Thr Trp Ile Lys Asn Gln 
        435                 440                 445             


Asp Asp Ser Leu Thr Glu Thr Asp Thr Leu Glu Ile Thr Asp Gln Asp 
    450                 455                 460                 


Met Phe Gly Asp Ala Ser Thr Ser Leu Val Val Pro Glu Lys Val Lys 
465                 470                 475                 480 


Thr Pro Met Lys Ser Ser Lys Thr Asp Leu Gln Gly Ser Ala Ser Pro 
                485                 490                 495     


Ser Lys Val Glu Gly Val His Thr Pro Arg Gln Lys Arg Ser Thr Pro 
            500                 505                 510         


Leu Lys Glu Arg Gln Leu Ser Lys Pro Leu Ser Glu Arg Thr Asn Ser 
        515                 520                 525             


Ser Asp Ser Glu Arg Ser Pro Asp Leu Gly His Ser Thr Gln Ile Pro 
    530                 535                 540                 


Arg Lys Val Val Tyr Asp Gln Leu Asn Gln Ile Leu Val Ser Asp Ala 
545                 550                 555                 560 


Ala Leu Pro Glu Asn Val Ile Leu Val Asn Thr Thr Asp Trp Gln Gly 
                565                 570                 575     


Gln Tyr Val Ala Glu Leu Leu Gln Asp Gln Arg Lys Pro Val Val Cys 
            580                 585                 590         


Thr Cys Ser Thr Val Glu Val Gln Ala Val Leu Ser Ala Leu Leu Thr 
        595                 600                 605             


Arg Ile Gln Arg Tyr Cys Asn Cys Asn Ser Ser Met Pro Arg Pro Val 
    610                 615                 620                 


Lys Val Ala Ala Val Gly Gly Gln Ser Tyr Leu Ser Ser Ile Leu Arg 
625                 630                 635                 640 


Phe Phe Val Lys Ser Leu Ala Asn Lys Thr Ser Asp Trp Leu Gly Tyr 
                645                 650                 655     


Met Arg Phe Leu Ile Ile Pro Leu Gly Ser His Pro Val Ala Lys Tyr 
            660                 665                 670         


Leu Gly Ser Val Asp Ser Lys Tyr Ser Ser Ser Phe Leu Asp Ser Gly 
        675                 680                 685             


Trp Arg Asp Leu Phe Ser Arg Ser Glu Pro Pro Val Ser Glu Gln Leu 
    690                 695                 700                 


Asp Val Ala Gly Arg Val Met Gln Tyr Val Asn Gly Ala Ala Thr Thr 
705                 710                 715                 720 


His Gln Leu Pro Val Ala Glu Ala Met Leu Thr Cys Arg His Lys Phe 
                725                 730                 735     


Pro Asp Glu Asp Ser Tyr Gln Lys Phe Ile Pro Phe Ile Gly Val Val 
            740                 745                 750         


Lys Val Gly Leu Val Glu Asp Ser Pro Ser Thr Ala Gly Asp Gly Asp 
        755                 760                 765             


Asp Ser Pro Val Val Ser Leu Thr Val Pro Ser Thr Ser Pro Pro Ser 
    770                 775                 780                 


Ser Ser Gly Leu Ser Arg Asp Ala Thr Ala Thr Pro Pro Ser Ser Pro 
785                 790                 795                 800 


Ser Met Ser Ser Ala Leu Ala Ile Val Gly Ser Pro Asn Ser Pro Tyr 
                805                 810                 815     


Gly Asp Val Ile Gly Leu Gln Val Asp Tyr Trp Leu Gly His Pro Gly 
            820                 825                 830         


Glu Arg Arg Arg Glu Gly Asp Lys Arg Asp Ala Ser Ser Lys Asn Thr 
        835                 840                 845             


Leu Lys Ser Val Phe Arg Ser Val Gln Val Ser Arg Leu Pro His Ser 
    850                 855                 860                 


Gly Glu Ala Gln Leu Ser Gly Thr Met Ala Met Thr Val Val Thr Lys 
865                 870                 875                 880 


Glu Lys Asn Lys Lys Val Pro Thr Ile Phe Leu Ser Lys Lys Pro Arg 
                885                 890                 895     


Glu Lys Glu Val Asp Ser Lys Ser Gln Val Ile Glu Gly Ile Ser Arg 
            900                 905                 910         


Leu Ile Cys Ser Ala Lys Gln Gln Gln Thr Met Leu Arg Val Ser Ile 
        915                 920                 925             


Asp Gly Val Glu Trp Ser Asp Ile Lys Phe Phe Gln Leu Ala Ala Gln 
    930                 935                 940                 


Trp Pro Thr His Val Lys His Phe Pro Val Gly Leu Phe Ser Gly Ser 
945                 950                 955                 960 


Lys Ala Thr 
            


<210>  2690
<211>  2992
<212>  DNA
<213>  Homosapiens

<400>  2690
ggcgggatgg aggcggcggg accggctcgc gggtgcgggt ccgggtgaag cgggaggcag     60

ccagagtcgg agccgggccc gagcaccagg cgcaggcccg gcgcccgcct gcccgcaccc    120

tcgtcctcac agacgccaca gccatggcca tgatggtgtt tccgcgggag gagaagctga    180

gccaggatga gatcgtgctg ggcaccaagg ctgtcatcca gggactggag actctgcgtg    240

gggagcatcg tgccctgctg gctcctctgg ttgcacctga ggccggcgaa gccgagcctg    300

gctcgcagga gcgctgcatc ctcctgcgtc gctccctgga agccattgag cttgggctgg    360

gggaggccca ggtgatcttg gcattgtcga gccacctggg ggctgtagaa tcagagaagc    420

agaagctgcg ggcgcaggtg cggcgtctgg tgcaggagaa ccagtggctg cgtgaggagc    480

tggcggggac acagcagaag ctgcagcgca gtgagcaggc cgtggcccag ctcgaggagg    540

agaagcagca cttgctgttc atgagccaga tccgcaagtt ggatgaagac gcctccccta    600

acgaggagaa gggggacgtc cccaaagaca cactggatga cctgttcccc aatgaggatg    660

agcagagccc agcccctagc ccaggaggag gggatgtgtc tggtcagcat gggggctacg    720

agatcccggc ccggctccgc accctgcaca acctggtgat ccaatacgcc tcacagggcc    780

gctacgaggt agctgtgcca ctctgcaagc aggcactcga agacctggag aagacgtcag    840

gccacgacca ccctgacgtt gccaccatgc tgaacatcct ggcactggtc tatcgggatc    900

agaacaagta caaggaggct gcccacctgc tcaatgatgc tctggccatc cgggagaaaa    960

cactgggcaa ggaccaccca gccgtggctg cgacactaaa caacctggca gtcctgtatg   1020

gcaagagggg caagtacaag gaggctgagc cattgtgcaa gcgggcactg gagatccggg   1080

agaaggtcct gggcaagttt cacccagatg tggccaagca gctcagcaac ctggccctgc   1140

tgtgccagaa ccagggcaaa gctgaggagg tggaatatta ctatcggcgg gcactggaga   1200

tctatgctac acgcctcggg cccgatgacc ccaatgtggc caagaccaag aacaacctgg   1260

cttcctgcta cctgaagcag ggcaagtacc aggatgcgga gaccttgtac aaggagatcc   1320

tcacccgcgc tcatgagaaa gagtttggct ctgtcaatgg ggacaacaag cccatctgga   1380

tgcacgcaga ggagcgggag gaaagcaagg ataagcgccg ggacagcgcc ccctatgggg   1440

aatacggcag ctggtacaag gcctgtaaag tagacagccc cacagtcaac accaccctgc   1500

gcagcttggg ggccctatac cggcgccagg gcaagctgga agccgcgcac acactagagg   1560

actgtgccag ccgtaaccgc aagcagggtt tggaccccgc aagccagacc aaggtggtag   1620

aactgctgaa agatggcagt ggcaggcggg gagaccgccg cagcagccga gacatggctg   1680

ggggtgccgg gcctcggtct gagtctgacc tcgaggacgt gggacctaca gctgagtgga   1740

atggggatgg cagtggctcc ttgaggcgca gcggttcctt tgggaaactc cgggatgccc   1800

tgaggcgcag cagtgagatg ctggtaaaga agctgcaggg gggcaccccc caggagcccc   1860

ctaaccccag gatgaagcgg gccagttccc tcaacttcct caacaagagc gtggaagagc   1920

cgacccagcc tggaggcaca ggtctctctg acagccgcac tctcagctcc agctccatgg   1980

acctctcccg acgaagctcc ctggtgggct aatgctgaag gggcagccag tcaccagagc   2040

gcccacctgg cacacccccc tcaccccagc cctgcgcatg ggcctgctgc ttgtcccgcc   2100

tgtctctccc acagcccctg tcttttctgt tcaatctcag ggtaaccttc tcccttgtca   2160

tctcagcctg agccctggag gctgggcctg cccactccag ctccatccct tatttattcc   2220

ttccagcagg gccctcttcc ctaggttcgg gccagcagga ggtgccggct ggagtctcca   2280

ccatagactc agtggcctgg cctccccaga ccccagagcc aagaacacta agcactcgcc   2340

ggcccttcgg caccctcgcc ctccctcccg actcaacccg gccgttgctt ctgtatatag   2400

agaaataagt tattggccgc gcgcctccct tcagtccacg gtactacccg ggcctcccct   2460

cgtccctctt ctagtggtac cgcccaggcc ttaatcaccc ccattccgtg cggtggtatc   2520

tcccaggctc tacattctcg ggagcggcgc ctcccaaggg ggtcctggga ccttctcgcg   2580

ctcctcctgg cctctgaggg atgcgtccta cccgcgccat cgccccgtgg cccaggacgg   2640

ggacctcccc ttagtccgtc ctcccaccgc cgggccctgc cccgcatccc ggccttatgc   2700

actgcccctc ccacccggcc ccgcccaggc acggccgacc ccgccccggg caccgcccac   2760

cgagccatcc tgcctcgcct ccccccacgc ctgcagcttc tcgcgagggg cggcgacggt   2820

cccctggtgg caggaggggc tccccctgtt gcgggtgagg cggctgctct ctattttcag   2880

atgttgctgt agaaataaag acggtttaaa tctgaaaaaa aaaaaaaaaa aaaaaaaaaa   2940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa           2992


<210>  2691
<211>  622
<212>  PRT
<213>  Homosapiens

<400>  2691

Met Ala Met Met Val Phe Pro Arg Glu Glu Lys Leu Ser Gln Asp Glu 
1               5                   10                  15      


Ile Val Leu Gly Thr Lys Ala Val Ile Gln Gly Leu Glu Thr Leu Arg 
            20                  25                  30          


Gly Glu His Arg Ala Leu Leu Ala Pro Leu Val Ala Pro Glu Ala Gly 
        35                  40                  45              


Glu Ala Glu Pro Gly Ser Gln Glu Arg Cys Ile Leu Leu Arg Arg Ser 
    50                  55                  60                  


Leu Glu Ala Ile Glu Leu Gly Leu Gly Glu Ala Gln Val Ile Leu Ala 
65                  70                  75                  80  


Leu Ser Ser His Leu Gly Ala Val Glu Ser Glu Lys Gln Lys Leu Arg 
                85                  90                  95      


Ala Gln Val Arg Arg Leu Val Gln Glu Asn Gln Trp Leu Arg Glu Glu 
            100                 105                 110         


Leu Ala Gly Thr Gln Gln Lys Leu Gln Arg Ser Glu Gln Ala Val Ala 
        115                 120                 125             


Gln Leu Glu Glu Glu Lys Gln His Leu Leu Phe Met Ser Gln Ile Arg 
    130                 135                 140                 


Lys Leu Asp Glu Asp Ala Ser Pro Asn Glu Glu Lys Gly Asp Val Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Asp Asp Leu Phe Pro Asn Glu Asp Glu Gln Ser Pro 
                165                 170                 175     


Ala Pro Ser Pro Gly Gly Gly Asp Val Ser Gly Gln His Gly Gly Tyr 
            180                 185                 190         


Glu Ile Pro Ala Arg Leu Arg Thr Leu His Asn Leu Val Ile Gln Tyr 
        195                 200                 205             


Ala Ser Gln Gly Arg Tyr Glu Val Ala Val Pro Leu Cys Lys Gln Ala 
    210                 215                 220                 


Leu Glu Asp Leu Glu Lys Thr Ser Gly His Asp His Pro Asp Val Ala 
225                 230                 235                 240 


Thr Met Leu Asn Ile Leu Ala Leu Val Tyr Arg Asp Gln Asn Lys Tyr 
                245                 250                 255     


Lys Glu Ala Ala His Leu Leu Asn Asp Ala Leu Ala Ile Arg Glu Lys 
            260                 265                 270         


Thr Leu Gly Lys Asp His Pro Ala Val Ala Ala Thr Leu Asn Asn Leu 
        275                 280                 285             


Ala Val Leu Tyr Gly Lys Arg Gly Lys Tyr Lys Glu Ala Glu Pro Leu 
    290                 295                 300                 


Cys Lys Arg Ala Leu Glu Ile Arg Glu Lys Val Leu Gly Lys Phe His 
305                 310                 315                 320 


Pro Asp Val Ala Lys Gln Leu Ser Asn Leu Ala Leu Leu Cys Gln Asn 
                325                 330                 335     


Gln Gly Lys Ala Glu Glu Val Glu Tyr Tyr Tyr Arg Arg Ala Leu Glu 
            340                 345                 350         


Ile Tyr Ala Thr Arg Leu Gly Pro Asp Asp Pro Asn Val Ala Lys Thr 
        355                 360                 365             


Lys Asn Asn Leu Ala Ser Cys Tyr Leu Lys Gln Gly Lys Tyr Gln Asp 
    370                 375                 380                 


Ala Glu Thr Leu Tyr Lys Glu Ile Leu Thr Arg Ala His Glu Lys Glu 
385                 390                 395                 400 


Phe Gly Ser Val Asn Gly Asp Asn Lys Pro Ile Trp Met His Ala Glu 
                405                 410                 415     


Glu Arg Glu Glu Ser Lys Asp Lys Arg Arg Asp Ser Ala Pro Tyr Gly 
            420                 425                 430         


Glu Tyr Gly Ser Trp Tyr Lys Ala Cys Lys Val Asp Ser Pro Thr Val 
        435                 440                 445             


Asn Thr Thr Leu Arg Ser Leu Gly Ala Leu Tyr Arg Arg Gln Gly Lys 
    450                 455                 460                 


Leu Glu Ala Ala His Thr Leu Glu Asp Cys Ala Ser Arg Asn Arg Lys 
465                 470                 475                 480 


Gln Gly Leu Asp Pro Ala Ser Gln Thr Lys Val Val Glu Leu Leu Lys 
                485                 490                 495     


Asp Gly Ser Gly Arg Arg Gly Asp Arg Arg Ser Ser Arg Asp Met Ala 
            500                 505                 510         


Gly Gly Ala Gly Pro Arg Ser Glu Ser Asp Leu Glu Asp Val Gly Pro 
        515                 520                 525             


Thr Ala Glu Trp Asn Gly Asp Gly Ser Gly Ser Leu Arg Arg Ser Gly 
    530                 535                 540                 


Ser Phe Gly Lys Leu Arg Asp Ala Leu Arg Arg Ser Ser Glu Met Leu 
545                 550                 555                 560 


Val Lys Lys Leu Gln Gly Gly Thr Pro Gln Glu Pro Pro Asn Pro Arg 
                565                 570                 575     


Met Lys Arg Ala Ser Ser Leu Asn Phe Leu Asn Lys Ser Val Glu Glu 
            580                 585                 590         


Pro Thr Gln Pro Gly Gly Thr Gly Leu Ser Asp Ser Arg Thr Leu Ser 
        595                 600                 605             


Ser Ser Ser Met Asp Leu Ser Arg Arg Ser Ser Leu Val Gly 
    610                 615                 620         


<210>  2692
<211>  1985
<212>  DNA
<213>  Homosapiens

<400>  2692
gggagcagag tcgactggga gcgaccgagc gggccgccgc cgccgccatg aaccccgaat     60

atgactacct gtttaagctg cttttgattg gcgactcagg cgtgggcaag tcatgcctgc    120

tcctgcggtt tgctgatgac acgtacacag agagctacat cagcaccatc ggggtggact    180

tcaagatccg aaccatcgag ctggatggca aaactatcaa acttcagatc tgggacacag    240

cgggccagga acggttccgg accatcactt ccagctacta ccggggggct catggcatca    300

tcgtggtgta tgacgtcact gaccaggaat cctacgccaa cgtgaagcag tggctgcagg    360

agattgaccg ctatgccagc gagaacgtca ataagctcct ggtgggcaac aagagcgacc    420

tcaccaccaa gaaggtggtg gacaacacca cagccaagga gtttgcagac tctctgggca    480

tccccttctt ggagacgagc gccaagaatg ccaccaatgt cgagcaggcg ttcatgacca    540

tggctgctga aatcaaaaag cggatggggc ctggagcagc ctctgggggc gagcggccca    600

atctcaagat cgacagcacc cctgtaaagc cggctggcgg tggctgttgc taggaggggc    660

acatggagtg ggacaggagg gggcaccttc tccagatgat gtccctggag gggggaggag    720

gtacctccct ctccctctcc tggggcattt gagtctgtgg ctttggggtg tcctgggctc    780

cccatctcct tctggcccat ctgcctgctg ccctgagccc cggttctgtc agggtcccta    840

agggaggaca ctcagggcct gtggccaggc agggcggagg cctgctgtgc agttgcctct    900

aggtgacttt ccaagatgcc cccctacaca cctttctttg gaacgagggc tcttctgtcg    960

gtgtccctcc cacccccatg tatgctgcac tgggttctct ccttcttctt cctgctgtcc   1020

tgcccaagaa ctgagggtct ccccggcctc tactgccctg gctgcagtca gtgcccaggg   1080

cgaggaatgt ggccagggga tccaggacct gggatccagg gccctgggct ggacctcagg   1140

acaggcatgg aggccacagg ggcccagcag cccacccttt cctctcccca ctgcctcctc   1200

tcccttccta cactcccagc tcgagccgtc cagctgcggt gggatctgag tatatctagg   1260

gcgggtgggc gggtagcagt gctgggcctg tgtcttgagc ctggagggag actgctcctg   1320

ccgccctctg ccctgccgga gacagaccca tgcgctgcct gcccaccgtg cccctttgtc   1380

cccatgtcag gcggaggcgg aaggcccacc gtgccagagg ctgggcacca gccttaaccc   1440

tcactctgct agcacctcct ccctttcccc aaggtagcac atctggctca ctccccactc   1500

cgtctctgga gcccaccagg gaaggccctc atcccctgcc gctacttctc tggggaatgt   1560

gggttccatc caggattggg ggcctctctg ctcacccact ctgcacccag gatcctagtc   1620

ccctgccctc tggcacagct gcttcctgca agaaagcaag tctttggtct ccctgagaag   1680

ccatgtccct cgtgctgtct cttgcctgtc ccacctgtgc cctgccctcc agcttgtatt   1740

taagtccctg ggctgccccc ttggggtgcc ccccgctccc aggttcccct ctggtgtcat   1800

gtcaggcatt ttgcaaggaa aagccacttg gggaaagatg gaaaaggaca aaaaaaatta   1860

ataaatttcc attggccctc gggtgagctg agggtttttg caaggaaaaa aaaaaaaaaa   1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaagaaaaa aaaaaaaaaa   1980

aaaaa                                                               1985


<210>  2693
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  2693

Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Thr 
            20                  25                  30          


Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Arg 
        35                  40                  45              


Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Ser Ser Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr 
                85                  90                  95      


Ala Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr Ala Ser Glu 
            100                 105                 110         


Asn Val Asn Lys Leu Leu Val Gly Asn Lys Ser Asp Leu Thr Thr Lys 
        115                 120                 125             


Lys Val Val Asp Asn Thr Thr Ala Lys Glu Phe Ala Asp Ser Leu Gly 
    130                 135                 140                 


Ile Pro Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn Val Glu Gln 
145                 150                 155                 160 


Ala Phe Met Thr Met Ala Ala Glu Ile Lys Lys Arg Met Gly Pro Gly 
                165                 170                 175     


Ala Ala Ser Gly Gly Glu Arg Pro Asn Leu Lys Ile Asp Ser Thr Pro 
            180                 185                 190         


Val Lys Pro Ala Gly Gly Gly Cys Cys 
        195                 200     


<210>  2694
<211>  1399
<212>  DNA
<213>  Homosapiens

<400>  2694
cgcaggatga gcgatcgggg cccgggcagc cggcagcgga cgcgcccccc gagcccaccg     60

gcccgcgccc cgcgcccccc acggccccgc ggtcccggtc ccggccgcat cacccacgtc    120

ccccgagccc cacgggccat gcccggccgg ccctaagcgc gggccggggg gcgtcccctt    180

gcgcccgggc cccgcgctgg cgccccccgg gccgccgccc ggcgcggggg ccatggcgtt    240

caccttcgcc gcgttctgct acatgctcac cctggtgctg tgcgcctccc tcatcttctt    300

tgtcatctgg cacatcatag cctttgatga gctgcggacc gacttcaaga accccatcga    360

ccaggggaac cctgcgcggg cacgcgagcg tttaaaaaac atcgaacgca tctgctgcct    420

cctgaggaag ctggtggtcc cagaatactc catccacggc ctcttctgtc tgatgtttct    480

gtgtgcagca gagtgggtga ccctgggcct caacatcccc ctcctcttct accacctctg    540

gaggtacttc caccgtcctg cagatggctc tgaggtcatg tatgatgcgg tctccatcat    600

gaatgctgac attctcaact actgccagaa ggagtcctgg tgcaaacttg ccttctacct    660

gctctccttc ttctattacc tgtacagtat ggtttatacg ttggtgagtt tctaaggggg    720

aagccggcca gggagcgagc ccagaacgga ccggacgcct gtgcaccccc agccctgccc    780

cttggccgca gaggcctcag ccctggggag ggagggggca ctggtgcccc cagcctctcc    840

aacccccaaa ctgctgctgc ggggaacccc ccccaccccg ccttcagagc cctccccctt    900

ggactagagc ggctgggcag agctctaaac aggggcaggg gctcctctgc cagcctgtgg    960

gcatggcagt cattcctgga aggggcagga cctccggcct tgtccatttc gggggaaact   1020

tgggccctgc caaggggcag agcttgaccc tggaaattct gggccatccc cctccacccc   1080

caccctgagg ctccccctgc aggtgggggg gtacccgcac cgggaatgag caggctcagc   1140

aggggggcag ccccacccct agtctgccct cccctctccc ccaggctctt tctccagccc   1200

tgtctccatc tgccccaacc tcagcccacc ttgtctcttg gacctatttt ctatgtcgcc   1260

tggaggagtc cggcaccccc tccccggcca tttgtgacaa aatatgaata aactactgca   1320

aatatgtggg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1380

aaaaaaaaaa aaaaaaaaa                                                1399


<210>  2695
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  2695

Met Ala Phe Thr Phe Ala Ala Phe Cys Tyr Met Leu Thr Leu Val Leu 
1               5                   10                  15      


Cys Ala Ser Leu Ile Phe Phe Val Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Arg Thr Asp Phe Lys Asn Pro Ile Asp Gln Gly Asn Pro Ala 
        35                  40                  45              


Arg Ala Arg Glu Arg Leu Lys Asn Ile Glu Arg Ile Cys Cys Leu Leu 
    50                  55                  60                  


Arg Lys Leu Val Val Pro Glu Tyr Ser Ile His Gly Leu Phe Cys Leu 
65                  70                  75                  80  


Met Phe Leu Cys Ala Ala Glu Trp Val Thr Leu Gly Leu Asn Ile Pro 
                85                  90                  95      


Leu Leu Phe Tyr His Leu Trp Arg Tyr Phe His Arg Pro Ala Asp Gly 
            100                 105                 110         


Ser Glu Val Met Tyr Asp Ala Val Ser Ile Met Asn Ala Asp Ile Leu 
        115                 120                 125             


Asn Tyr Cys Gln Lys Glu Ser Trp Cys Lys Leu Ala Phe Tyr Leu Leu 
    130                 135                 140                 


Ser Phe Phe Tyr Tyr Leu Tyr Ser Met Val Tyr Thr Leu Val Ser Phe 
145                 150                 155                 160 


<210>  2696
<211>  1078
<212>  DNA
<213>  Homosapiens

<400>  2696
gtgtcgcgcg gcgcggtggc ctcggtcggt accctgggcg cggacgagct gcctcattag     60

tattcgtacc cacgaggcgg cgcacggggc cctcggggac agcgagcgtc gcgccatggc    120

ttatcactcg ggctacggag cccacggctc caagcacagg gcccgggcag ccccggatcc    180

ccctcccctc ttcgatgaca caagcggtgg ttattccagc cagcccgggg gatacccagc    240

cacaggagca gacgtggcct tcagtgtcaa ccacttgctt ggggacccaa tggccaatgt    300

ggctatggcc tatggcagct ccatcgcatc ccatgggaag gacatggtgc acaaggagct    360

gcaccgtttt gtgtctgtga gcaaactcaa gtattttttt gctgtggaca cagcctacgt    420

ggccaagaag ctagggctgc tggtcttccc ctacacacac cagaactggg aagtgcagta    480

cagtcgtgat gctcctctgc ccccccggca agacctcaac gcccctgacc tctatatccc    540

cacgaaggcc ttcattactt acgtgctcct ggctgggatg gcactgggca ttcagaaaag    600

gttctccccg gaggtgctgg gcctgtgtgc aagcacagcg ctggtgtggg tggtgatgga    660

ggtgctggcc ctgctcctgg gcctctacct ggccaccgtg cgcagtgacc tgagcacctt    720

tcacctgctg gcctacagtg gctacaaata cgtgggaatg atcctcagtg tgctcacggg    780

gctgctgttc ggcagcgatg gctactacgt ggcgctggcc tggacctcat cggcgctcat    840

gtacttcatt gtgcgctctt tgcggacagc agccctgggc cccgacagca tggggggccc    900

cgtcccccgg cagcgtctcc agctctacct gactctggga gctgcagcct tccagcccct    960

catcatatac tggctgactt tccacctggt ccggtgaccc cctggcccca gatggcactg   1020

agtttttcat tcattgaaga tttgatttcc ttgaaaaaaa aaaaaaaaaa aaaaaaaa     1078


<210>  2697
<211>  293
<212>  PRT
<213>  Homosapiens

<400>  2697

Met Ala Tyr His Ser Gly Tyr Gly Ala His Gly Ser Lys His Arg Ala 
1               5                   10                  15      


Arg Ala Ala Pro Asp Pro Pro Pro Leu Phe Asp Asp Thr Ser Gly Gly 
            20                  25                  30          


Tyr Ser Ser Gln Pro Gly Gly Tyr Pro Ala Thr Gly Ala Asp Val Ala 
        35                  40                  45              


Phe Ser Val Asn His Leu Leu Gly Asp Pro Met Ala Asn Val Ala Met 
    50                  55                  60                  


Ala Tyr Gly Ser Ser Ile Ala Ser His Gly Lys Asp Met Val His Lys 
65                  70                  75                  80  


Glu Leu His Arg Phe Val Ser Val Ser Lys Leu Lys Tyr Phe Phe Ala 
                85                  90                  95      


Val Asp Thr Ala Tyr Val Ala Lys Lys Leu Gly Leu Leu Val Phe Pro 
            100                 105                 110         


Tyr Thr His Gln Asn Trp Glu Val Gln Tyr Ser Arg Asp Ala Pro Leu 
        115                 120                 125             


Pro Pro Arg Gln Asp Leu Asn Ala Pro Asp Leu Tyr Ile Pro Thr Lys 
    130                 135                 140                 


Ala Phe Ile Thr Tyr Val Leu Leu Ala Gly Met Ala Leu Gly Ile Gln 
145                 150                 155                 160 


Lys Arg Phe Ser Pro Glu Val Leu Gly Leu Cys Ala Ser Thr Ala Leu 
                165                 170                 175     


Val Trp Val Val Met Glu Val Leu Ala Leu Leu Leu Gly Leu Tyr Leu 
            180                 185                 190         


Ala Thr Val Arg Ser Asp Leu Ser Thr Phe His Leu Leu Ala Tyr Ser 
        195                 200                 205             


Gly Tyr Lys Tyr Val Gly Met Ile Leu Ser Val Leu Thr Gly Leu Leu 
    210                 215                 220                 


Phe Gly Ser Asp Gly Tyr Tyr Val Ala Leu Ala Trp Thr Ser Ser Ala 
225                 230                 235                 240 


Leu Met Tyr Phe Ile Val Arg Ser Leu Arg Thr Ala Ala Leu Gly Pro 
                245                 250                 255     


Asp Ser Met Gly Gly Pro Val Pro Arg Gln Arg Leu Gln Leu Tyr Leu 
            260                 265                 270         


Thr Leu Gly Ala Ala Ala Phe Gln Pro Leu Ile Ile Tyr Trp Leu Thr 
        275                 280                 285             


Phe His Leu Val Arg 
    290             


<210>  2698
<211>  2574
<212>  DNA
<213>  Homosapiens

<400>  2698
gccgcgctcg ggctcgagct ccgcgcactc cctccgcggc cgctgagccg agcggacgcc     60

cccgggggcc gcgtcgcagc cctccgtgct cccccctatc atgcccggtg cccaggctgg    120

ggccgccaag cagccaggac accatgcccg aggacggcgc tggcgacggc ggggaggtgc    180

ccgcgctcat cccggacggc gagccgctgc gggaagagca gcggcccctg aaacagtccc    240

tgggaagctc cctgtgccgc gagtcgcact ggaagtgcct gctcctcacg ctgctcatcc    300

acgcctgcgg ggccgtggtg gcctggtgtc gcctggccac agtgccgcgg ctggtcctgg    360

ggcccgaggc cgccttggcc cggggagccg ggggcccgcc accgacctac ccggccagcc    420

cctgctccga tggctacctg tacatcccgc tggccttcgt ctccctcctc tacctcctct    480

acctggctga gtgctggcac tgtcacgtgc ggtcctgcca ggcgccacgc accgacgccc    540

acacggtgct ggcgctgatc cgccggctgc agcaggcgcc gccgtgcgtc tggtggaagg    600

ccaccagcta tcactacgtg cggcgcacac gccagatcac gcgctaccgc aacggcgacg    660

cctacaccac cacgcaggtg taccatgagc gcgctgacag ccgcacggcc cgcggcgagt    720

ttgactactc ggcgcacggc gtccgcgacg tctccaagga gctggtgggg ctggcggagc    780

acgcggccac gcggctgcgc ttcaccaagt gcttcagctt cggcagcgcg gaggccgagg    840

cctcgtacct cacgcagcgg gcgcgcttct tcagcgccaa cgagggcctg gacgactatc    900

tggaggcgcg cgagggcatg cacctgaagg acgtagactt ccgcgagtcg ctcatggtct    960

tcgccgaccc ccgcagcccg ccctggtacg cgcgcgcctg ggtcttctgg ctcgtgtcgg   1020

cggccacgct gtcgtggccc ctgcgcgtcg tggccgccta tggcacggct cacgtgcact   1080

accaggtgga gaagctcttt ggcgccagct cgcccccgcc gggggccgtg cccagcgggc   1140

ccccgctgtc ccgcgtggcc acagtggact tcactgagct cgagtggcac atctgctcca   1200

accggcagct ggtgcccagc tactcggagg ccgtggtcat gggcgcgggc tcgggcgcct   1260

acctcagagg ctgccagcgc tgccgccgct ctgtcagcag caactcgctg ccccccgccc   1320

ggcccagcgg gccccgcctg cccttcagcc gcagccgcct ctcgctgggc gctggcggcc   1380

gggccacgcc aggggtcttc cgcagcctga gcggggggcc gctggggcgc cgtggagagg   1440

acacggaacc cctggagagc ccgccctgct atgaggacgc cctctacttc ccggtgctca   1500

ttgtccacgg agacagcggc tgccaggggg atgggcaggg tgctctctga gacccccacg   1560

gcccccagag tggccccctc cccaccattc caccatgggc ttagatgccc gagtgattgt   1620

tgtccaaaac aggcgggaaa acagaccagc cacacacaag gggcaggggt gagggtgggg   1680

gtgggggtcc ttaaacagac taaaatgcag ttacctgtgg tcattttgga ggaagtggaa   1740

gcctaagaat cgcccccagc atggcttcat cccccaagat ggccgatgat ctggcctgaa   1800

ggcctctcac aaagggcagg agaagaagct tccagaaagg ctgggatgga ggaggagtcc   1860

tgcggccagc tgttgcctgc agcagaggct gcctgtggac acttccctac cggggctgag   1920

gccatgctgg gagccccccc agtgacgcag aagcacaaat tggaggcttg gggccatgcc   1980

cagccaggtt ggcttccctg gggctgaaga gctggctgtg gtggcaccat ggccttggcc   2040

ctgctactca cccaacattc ccatcctccc ctgataggcc cctcctcctt gcctgccctc   2100

tctcccgctg ctcagggcca gtcactcccc ccacatgcag ctacccctac aacctggggt   2160

tccttctcag ggcctcacct ggtccccaca tcccctggcc tctgctcctg cctcccaaag   2220

tccatgtctg cctccatcag ccacacacac gcagggacgc ccgttccttg ccctcccgga   2280

cttatctact cttcactttc ctgatgatcc atggggccca ggcctagagg gcatccgagg   2340

ggctgggcct tggccacagc ctcttggatg atgtccttgc tccaccacgc aggcccttgc   2400

ttctcccatc aacgagtctt ggcccagggg acactgaccc tcccccaggg aggagagagg   2460

agttccttcc ctttcaacga gggcttccac gccctctaag gggtggcggg gaagggagga   2520

ggctgagaag atgcagatta aataaaggta tggaatagaa aaaaaaaaaa aaaa         2574


<210>  2699
<211>  468
<212>  PRT
<213>  Homosapiens

<400>  2699

Met Pro Glu Asp Gly Ala Gly Asp Gly Gly Glu Val Pro Ala Leu Ile 
1               5                   10                  15      


Pro Asp Gly Glu Pro Leu Arg Glu Glu Gln Arg Pro Leu Lys Gln Ser 
            20                  25                  30          


Leu Gly Ser Ser Leu Cys Arg Glu Ser His Trp Lys Cys Leu Leu Leu 
        35                  40                  45              


Thr Leu Leu Ile His Ala Cys Gly Ala Val Val Ala Trp Cys Arg Leu 
    50                  55                  60                  


Ala Thr Val Pro Arg Leu Val Leu Gly Pro Glu Ala Ala Leu Ala Arg 
65                  70                  75                  80  


Gly Ala Gly Gly Pro Pro Pro Thr Tyr Pro Ala Ser Pro Cys Ser Asp 
                85                  90                  95      


Gly Tyr Leu Tyr Ile Pro Leu Ala Phe Val Ser Leu Leu Tyr Leu Leu 
            100                 105                 110         


Tyr Leu Ala Glu Cys Trp His Cys His Val Arg Ser Cys Gln Ala Pro 
        115                 120                 125             


Arg Thr Asp Ala His Thr Val Leu Ala Leu Ile Arg Arg Leu Gln Gln 
    130                 135                 140                 


Ala Pro Pro Cys Val Trp Trp Lys Ala Thr Ser Tyr His Tyr Val Arg 
145                 150                 155                 160 


Arg Thr Arg Gln Ile Thr Arg Tyr Arg Asn Gly Asp Ala Tyr Thr Thr 
                165                 170                 175     


Thr Gln Val Tyr His Glu Arg Ala Asp Ser Arg Thr Ala Arg Gly Glu 
            180                 185                 190         


Phe Asp Tyr Ser Ala His Gly Val Arg Asp Val Ser Lys Glu Leu Val 
        195                 200                 205             


Gly Leu Ala Glu His Ala Ala Thr Arg Leu Arg Phe Thr Lys Cys Phe 
    210                 215                 220                 


Ser Phe Gly Ser Ala Glu Ala Glu Ala Ser Tyr Leu Thr Gln Arg Ala 
225                 230                 235                 240 


Arg Phe Phe Ser Ala Asn Glu Gly Leu Asp Asp Tyr Leu Glu Ala Arg 
                245                 250                 255     


Glu Gly Met His Leu Lys Asp Val Asp Phe Arg Glu Ser Leu Met Val 
            260                 265                 270         


Phe Ala Asp Pro Arg Ser Pro Pro Trp Tyr Ala Arg Ala Trp Val Phe 
        275                 280                 285             


Trp Leu Val Ser Ala Ala Thr Leu Ser Trp Pro Leu Arg Val Val Ala 
    290                 295                 300                 


Ala Tyr Gly Thr Ala His Val His Tyr Gln Val Glu Lys Leu Phe Gly 
305                 310                 315                 320 


Ala Ser Ser Pro Pro Pro Gly Ala Val Pro Ser Gly Pro Pro Leu Ser 
                325                 330                 335     


Arg Val Ala Thr Val Asp Phe Thr Glu Leu Glu Trp His Ile Cys Ser 
            340                 345                 350         


Asn Arg Gln Leu Val Pro Ser Tyr Ser Glu Ala Val Val Met Gly Ala 
        355                 360                 365             


Gly Ser Gly Ala Tyr Leu Arg Gly Cys Gln Arg Cys Arg Arg Ser Val 
    370                 375                 380                 


Ser Ser Asn Ser Leu Pro Pro Ala Arg Pro Ser Gly Pro Arg Leu Pro 
385                 390                 395                 400 


Phe Ser Arg Ser Arg Leu Ser Leu Gly Ala Gly Gly Arg Ala Thr Pro 
                405                 410                 415     


Gly Val Phe Arg Ser Leu Ser Gly Gly Pro Leu Gly Arg Arg Gly Glu 
            420                 425                 430         


Asp Thr Glu Pro Leu Glu Ser Pro Pro Cys Tyr Glu Asp Ala Leu Tyr 
        435                 440                 445             


Phe Pro Val Leu Ile Val His Gly Asp Ser Gly Cys Gln Gly Asp Gly 
    450                 455                 460                 


Gln Gly Ala Leu 
465             


<210>  2700
<211>  2576
<212>  DNA
<213>  Homosapiens

<400>  2700
agtccggggg catcgcgatg ctgctgcgcc tgttgctggc ctgggcggcc gcagggccca     60

cactgggcca ggacccctgg gctgctgagc cccgtgccgc ctgcggcccc agcagctgct    120

acgctctctt cccacggcgc cgcaccttcc tggaggcctg gcgggcctgc cgcgagctgg    180

ggggcgacct ggccactcct cggacccccg aggaggccca gcgtgtggac agcctggtgg    240

gtgcgggccc agccagccgg ctgctgtgga tcgggctgca gcggcaggcc cggcaatgcc    300

agctgcagcg cccactgcgc ggcttcacgt ggaccacagg ggaccaggac acggctttca    360

ccaactgggc ccagccagcc tctggaggcc cctgcccggc ccagcgctgt gtggccctgg    420

aggcaagtgg cgagcaccgc tggctggagg gctcgtgcac gctggctgtc gacggctacc    480

tgtgccagtt tggcttcgag ggcgcctgcc cggcgctgca agatgaggcg ggccaggccg    540

gcccagccgt gtataccacg cccttccacc tggtctccac agagtttgag tggctgccct    600

tcggctctgt ggccgctgtg cagtgccagg ctggcagggg agcctctctg ctctgcgtga    660

agcagcctga gggaggtgtg ggctggtcac gggctgggcc cctgtgcctg gggactggct    720

gcagccctga caacgggggc tgcgaacacg aatgtgtgga ggaggtggat ggtcacgtgt    780

cctgccgctg cactgagggc ttccggctgg cagcagacgg gcgcagttgc gaggacccct    840

gtgcccaggc tccgtgcgag cagcagtgtg agcccggtgg gccacaaggc tacagctgcc    900

actgtcgcct gggtttccgg ccagcggagg atgatccgca ccgctgtgtg gacacagatg    960

agtgccagat tgccggtgtg tgccagcaga tgtgtgtcaa ctacgttggt ggcttcgagt   1020

gttattgtag cgagggacat gagctggagg ctgatggcat cagctgcagc cctgcagggg   1080

ccatgggtgc ccaggcttcc caggacctcg gagatgagtt gctggatgac ggggaggatg   1140

aggaagatga agacgaggcc tggaaggcct tcaacggtgg ctggacggag atgcctggga   1200

tcctgtggat ggagcctacg cagccgcctg actttgccct ggcctataga ccgagcttcc   1260

cagaggacag agagccacag ataccctacc cggagcccac ctggccaccc ccgctcagtg   1320

cccccagggt cccctaccac tcctcagtgc tctccgtcac ccggcctgtg gtggtctctg   1380

ccacgcatcc cacactgcct tctgcccacc agcctcctgt gatccctgcc acacacccag   1440

ctttgtcccg tgaccaccag atccccgtga tcgcagccaa ctatccagat ctgccttctg   1500

cctaccaacc cggtattctc tctgtctctc attcagcaca gcctcctgcc caccagcccc   1560

ctatgatctc aaccaaatat ccggagctct tccctgccca ccagtccccc atgtttccag   1620

acacccgggt cgctggcacc cagaccacca ctcatttgcc tggaatccca cctaaccatg   1680

cccctctggt caccaccctc ggtgcccagc taccccctca agccccagat gcccttgtcc   1740

tcagaaccca ggccacccag cttcccatta tcccaactgc ccagccctct ctgaccacca   1800

cctccaggtc ccctgtgtct cctgcccatc aaatctctgt gcctgctgcc acccagcccg   1860

cagccctccc caccctcctg ccctctcaga gccccactaa ccagacctca cccatcagcc   1920

ctacacatcc ccattccaaa gccccccaaa tcccaaggga agatggcccc agtcccaagt   1980

tggccctgtg gctgccctca ccagctccca cagcagcccc aacagccctg ggggaggctg   2040

gtcttgccga gcacagccag agggatgacc ggtggctgct ggtggcactc ctggtgccaa   2100

cgtgtgtctt tttggtggtc ctgcttgcac tgggcatcgt gtactgcacc cgctgtggcc   2160

cccatgcacc caacaagcgc atcactgact gctatcgctg ggtcatccat gctgggagca   2220

agagcccaac agaacccatg ccccccaggg gcagcctcac aggggtgcag acctgcagaa   2280

ccagcgtgtg atggggtgca gacccccctc atggagtatg gggcgctgga cacatggccg   2340

gggctgcacc agggacccat gggggctgcc cagctggaca gatggcttcc tgctccccag   2400

gcccagccag ggtcctctct caaccactag acttggctct caggaactct gcttcctggc   2460

ccagcgctcg tgaccaagga tacaccaaag cccttaagac ctcagggggc gggtgctggg   2520

gtcttctcca ataaatgggg tgtcaacctt acccaaggaa aaaaaaaaaa aaaaaa       2576


<210>  2701
<211>  757
<212>  PRT
<213>  Homosapiens

<400>  2701

Met Leu Leu Arg Leu Leu Leu Ala Trp Ala Ala Ala Gly Pro Thr Leu 
1               5                   10                  15      


Gly Gln Asp Pro Trp Ala Ala Glu Pro Arg Ala Ala Cys Gly Pro Ser 
            20                  25                  30          


Ser Cys Tyr Ala Leu Phe Pro Arg Arg Arg Thr Phe Leu Glu Ala Trp 
        35                  40                  45              


Arg Ala Cys Arg Glu Leu Gly Gly Asp Leu Ala Thr Pro Arg Thr Pro 
    50                  55                  60                  


Glu Glu Ala Gln Arg Val Asp Ser Leu Val Gly Ala Gly Pro Ala Ser 
65                  70                  75                  80  


Arg Leu Leu Trp Ile Gly Leu Gln Arg Gln Ala Arg Gln Cys Gln Leu 
                85                  90                  95      


Gln Arg Pro Leu Arg Gly Phe Thr Trp Thr Thr Gly Asp Gln Asp Thr 
            100                 105                 110         


Ala Phe Thr Asn Trp Ala Gln Pro Ala Ser Gly Gly Pro Cys Pro Ala 
        115                 120                 125             


Gln Arg Cys Val Ala Leu Glu Ala Ser Gly Glu His Arg Trp Leu Glu 
    130                 135                 140                 


Gly Ser Cys Thr Leu Ala Val Asp Gly Tyr Leu Cys Gln Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Ala Cys Pro Ala Leu Gln Asp Glu Ala Gly Gln Ala Gly Pro 
                165                 170                 175     


Ala Val Tyr Thr Thr Pro Phe His Leu Val Ser Thr Glu Phe Glu Trp 
            180                 185                 190         


Leu Pro Phe Gly Ser Val Ala Ala Val Gln Cys Gln Ala Gly Arg Gly 
        195                 200                 205             


Ala Ser Leu Leu Cys Val Lys Gln Pro Glu Gly Gly Val Gly Trp Ser 
    210                 215                 220                 


Arg Ala Gly Pro Leu Cys Leu Gly Thr Gly Cys Ser Pro Asp Asn Gly 
225                 230                 235                 240 


Gly Cys Glu His Glu Cys Val Glu Glu Val Asp Gly His Val Ser Cys 
                245                 250                 255     


Arg Cys Thr Glu Gly Phe Arg Leu Ala Ala Asp Gly Arg Ser Cys Glu 
            260                 265                 270         


Asp Pro Cys Ala Gln Ala Pro Cys Glu Gln Gln Cys Glu Pro Gly Gly 
        275                 280                 285             


Pro Gln Gly Tyr Ser Cys His Cys Arg Leu Gly Phe Arg Pro Ala Glu 
    290                 295                 300                 


Asp Asp Pro His Arg Cys Val Asp Thr Asp Glu Cys Gln Ile Ala Gly 
305                 310                 315                 320 


Val Cys Gln Gln Met Cys Val Asn Tyr Val Gly Gly Phe Glu Cys Tyr 
                325                 330                 335     


Cys Ser Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser Cys Ser Pro 
            340                 345                 350         


Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu Gly Asp Glu Leu 
        355                 360                 365             


Leu Asp Asp Gly Glu Asp Glu Glu Asp Glu Asp Glu Ala Trp Lys Ala 
    370                 375                 380                 


Phe Asn Gly Gly Trp Thr Glu Met Pro Gly Ile Leu Trp Met Glu Pro 
385                 390                 395                 400 


Thr Gln Pro Pro Asp Phe Ala Leu Ala Tyr Arg Pro Ser Phe Pro Glu 
                405                 410                 415     


Asp Arg Glu Pro Gln Ile Pro Tyr Pro Glu Pro Thr Trp Pro Pro Pro 
            420                 425                 430         


Leu Ser Ala Pro Arg Val Pro Tyr His Ser Ser Val Leu Ser Val Thr 
        435                 440                 445             


Arg Pro Val Val Val Ser Ala Thr His Pro Thr Leu Pro Ser Ala His 
    450                 455                 460                 


Gln Pro Pro Val Ile Pro Ala Thr His Pro Ala Leu Ser Arg Asp His 
465                 470                 475                 480 


Gln Ile Pro Val Ile Ala Ala Asn Tyr Pro Asp Leu Pro Ser Ala Tyr 
                485                 490                 495     


Gln Pro Gly Ile Leu Ser Val Ser His Ser Ala Gln Pro Pro Ala His 
            500                 505                 510         


Gln Pro Pro Met Ile Ser Thr Lys Tyr Pro Glu Leu Phe Pro Ala His 
        515                 520                 525             


Gln Ser Pro Met Phe Pro Asp Thr Arg Val Ala Gly Thr Gln Thr Thr 
    530                 535                 540                 


Thr His Leu Pro Gly Ile Pro Pro Asn His Ala Pro Leu Val Thr Thr 
545                 550                 555                 560 


Leu Gly Ala Gln Leu Pro Pro Gln Ala Pro Asp Ala Leu Val Leu Arg 
                565                 570                 575     


Thr Gln Ala Thr Gln Leu Pro Ile Ile Pro Thr Ala Gln Pro Ser Leu 
            580                 585                 590         


Thr Thr Thr Ser Arg Ser Pro Val Ser Pro Ala His Gln Ile Ser Val 
        595                 600                 605             


Pro Ala Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln 
    610                 615                 620                 


Ser Pro Thr Asn Gln Thr Ser Pro Ile Ser Pro Thr His Pro His Ser 
625                 630                 635                 640 


Lys Ala Pro Gln Ile Pro Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala 
                645                 650                 655     


Leu Trp Leu Pro Ser Pro Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly 
            660                 665                 670         


Glu Ala Gly Leu Ala Glu His Ser Gln Arg Asp Asp Arg Trp Leu Leu 
        675                 680                 685             


Val Ala Leu Leu Val Pro Thr Cys Val Phe Leu Val Val Leu Leu Ala 
    690                 695                 700                 


Leu Gly Ile Val Tyr Cys Thr Arg Cys Gly Pro His Ala Pro Asn Lys 
705                 710                 715                 720 


Arg Ile Thr Asp Cys Tyr Arg Trp Val Ile His Ala Gly Ser Lys Ser 
                725                 730                 735     


Pro Thr Glu Pro Met Pro Pro Arg Gly Ser Leu Thr Gly Val Gln Thr 
            740                 745                 750         


Cys Arg Thr Ser Val 
        755         


<210>  2702
<211>  2698
<212>  DNA
<213>  Homosapiens

<400>  2702
gtggacacac aagagttaac tggcgggtgt gacaggcgga ccgccctcag gaagtgttac     60

tcactgggga tgtgcgtgcc ttgccttggg actggattct cttcctgaag cgaaggagct    120

cccagccatg gaaagccctg gagagtcagg cgcgggctct cctggagccc ccagcccgtc    180

cagcttcact actgggcacc tggcgagaga aaagccagcc caggacccac tgtatgacgt    240

gcccaatgcc agcggcgggc aggcaggcgg gccgcagcgg ccggggcgcg ttgtgagcct    300

gcgggagcgc ctgctgctca cccggcccgt gtggctgcag ctgcaagcca acgcagcggc    360

cgcactgcac atgctgagga ccgagccccc ggggacgttc ctcgtgcgga aatctaacac    420

ccgccagtgc caggccctgt gcatgcggtt gcctgaagcc agtggcccct ccttcgtctc    480

cagccactac atcctggaga gccctggcgg cgtctccttg gagggctcgg agctcatgtt    540

cccagaccta gtccagctca tctgtgccta ctgccacacc cgggacatcc ttctcctccc    600

gctgcagctc cccagagcca tccaccacgc agccactcac aaagagctgg aggccatctc    660

ccatctgggc attgagttct ggagctcctc cctcaacatc aaggctcagc ggggcccggc    720

tggaggccca gtgttgcccc agctgaaggc ccggtcccct caagagctgg accagggcac    780

cggagccgcc ttgtgcttct tcaaccccct gttcccgggg gacctagggc ccaccaagcg    840

ggagaaattc aagagaagct tcaaagtgcg cgtgtccaca gagacctcca gccccctgtc    900

tccacctgcc gtgccacctc cccccgtccc cgtgctgcca ggggcagtcc ccagccagac    960

agagcggctg cccccttgcc agctgctacg gagggagagc tcagtggggt accgcgtgcc   1020

agcaggcagt ggccctagcc ttccgcctat gccctccctc caagaggtgg actgcggctc   1080

ccccagcagc tccgaggagg agggggtgcc agggtcccgg gggagcccag cgacctcacc   1140

ccacctgggc cgccgacgac ctctgcttcg gtccatgagc gccgccttct gctccctact   1200

ggcaccggag cggcaggtgg gccgggctgc ggcagcactg atgcaggacc gacacacagc   1260

cgcgggccag ctggtgcagg acctactgac ccaggtgcgg gctgggcccg agccccagga   1320

gctgcagggc atccgtcagg cgctgagccg ggcccgggcc atgctgagtg cggagctggg   1380

ccctgagaag ctgctgtcgc ctaagaggct ggaacatgtc ctggagaagt cattgcattg   1440

ctctgtgctc aagcctctcc ggcccatcct ggcagcccgc ctgcggcgcc ggcttgccgc   1500

agacggctcc ctgggccgcc tagctgaggg cctccgcctg gcccgggccc agggccccgg   1560

agccttcggg tcccacctga gcctgccctc cccagtagag ttggagcaag tgcgccagaa   1620

gctgctgcag ctgctccgca cctactcacc cagcgcccag gtcaagcggc tcctgcaggc   1680

ctgcaagctg ctctacatgg ccctgaggac ccaggaaggg gagggcgcgg gtgccgacga   1740

gttcctgcct ctgctgagcc tcgtcttggc ccactgtgac cttcctgagc tgctgctgga   1800

ggccgagtac atgtcggagc tgctggagcc cagcctgctt actggagagg gtggctacta   1860

cctgaccagc ctctctgcca gcctggccct gctgagtggc ctgggtcagg cccacaccct   1920

cccactgagc cccgtgcagg agctacggcg ctccctcagc ctctgggagc agcgccgcct   1980

gcctgccacc cactgcttcc agcacctcct ccgagtagcc tatcaggatc ccagcagtgg   2040

ctgcacctcc aagaccctgg ccgtgccccc agaagcctcg attgccaccc tgaaccagct   2100

ctgtgccacc aagttccgag tgacccagcc caacactttt ggcctcttcc tgtacaagga   2160

gcagggctac caccgcctgc cccctggggc cctggcccac aggctgccca ccactggcta   2220

cctcgtctac cgccgggcgg agtggcctga gacccagggg gctgtgacag aggaggaggg   2280

cagtgggcag tcagaggcaa gaagcagagg ggaggagcaa gggtgccagg gagatgggga   2340

tgctggggtc aaagccagcc ccagggacat tcgggaacag tctgagacaa ctgctgaagg   2400

gggccagggt caagcccagg aaggccctgc tcagccaggg gaaccagagg cagagggaag   2460

ccgggcagca gaggagtagc ttgaagtggc cagaagggtc attcggggcg ggagaccctg   2520

agcctgctga gaaatccttt tagcgccagc aagccccacc cagggccctg tcctgtgtct   2580

gccaccacct ttgtctgata cttgtttcca gggaagctgg gggaactgcc acatctgagg   2640

aactggaata aagatgaggg ggcttcgggg gcccccagac tgtgaaaaaa aaaaaaaa     2698


<210>  2703
<211>  783
<212>  PRT
<213>  Homosapiens

<400>  2703

Met Glu Ser Pro Gly Glu Ser Gly Ala Gly Ser Pro Gly Ala Pro Ser 
1               5                   10                  15      


Pro Ser Ser Phe Thr Thr Gly His Leu Ala Arg Glu Lys Pro Ala Gln 
            20                  25                  30          


Asp Pro Leu Tyr Asp Val Pro Asn Ala Ser Gly Gly Gln Ala Gly Gly 
        35                  40                  45              


Pro Gln Arg Pro Gly Arg Val Val Ser Leu Arg Glu Arg Leu Leu Leu 
    50                  55                  60                  


Thr Arg Pro Val Trp Leu Gln Leu Gln Ala Asn Ala Ala Ala Ala Leu 
65                  70                  75                  80  


His Met Leu Arg Thr Glu Pro Pro Gly Thr Phe Leu Val Arg Lys Ser 
                85                  90                  95      


Asn Thr Arg Gln Cys Gln Ala Leu Cys Met Arg Leu Pro Glu Ala Ser 
            100                 105                 110         


Gly Pro Ser Phe Val Ser Ser His Tyr Ile Leu Glu Ser Pro Gly Gly 
        115                 120                 125             


Val Ser Leu Glu Gly Ser Glu Leu Met Phe Pro Asp Leu Val Gln Leu 
    130                 135                 140                 


Ile Cys Ala Tyr Cys His Thr Arg Asp Ile Leu Leu Leu Pro Leu Gln 
145                 150                 155                 160 


Leu Pro Arg Ala Ile His His Ala Ala Thr His Lys Glu Leu Glu Ala 
                165                 170                 175     


Ile Ser His Leu Gly Ile Glu Phe Trp Ser Ser Ser Leu Asn Ile Lys 
            180                 185                 190         


Ala Gln Arg Gly Pro Ala Gly Gly Pro Val Leu Pro Gln Leu Lys Ala 
        195                 200                 205             


Arg Ser Pro Gln Glu Leu Asp Gln Gly Thr Gly Ala Ala Leu Cys Phe 
    210                 215                 220                 


Phe Asn Pro Leu Phe Pro Gly Asp Leu Gly Pro Thr Lys Arg Glu Lys 
225                 230                 235                 240 


Phe Lys Arg Ser Phe Lys Val Arg Val Ser Thr Glu Thr Ser Ser Pro 
                245                 250                 255     


Leu Ser Pro Pro Ala Val Pro Pro Pro Pro Val Pro Val Leu Pro Gly 
            260                 265                 270         


Ala Val Pro Ser Gln Thr Glu Arg Leu Pro Pro Cys Gln Leu Leu Arg 
        275                 280                 285             


Arg Glu Ser Ser Val Gly Tyr Arg Val Pro Ala Gly Ser Gly Pro Ser 
    290                 295                 300                 


Leu Pro Pro Met Pro Ser Leu Gln Glu Val Asp Cys Gly Ser Pro Ser 
305                 310                 315                 320 


Ser Ser Glu Glu Glu Gly Val Pro Gly Ser Arg Gly Ser Pro Ala Thr 
                325                 330                 335     


Ser Pro His Leu Gly Arg Arg Arg Pro Leu Leu Arg Ser Met Ser Ala 
            340                 345                 350         


Ala Phe Cys Ser Leu Leu Ala Pro Glu Arg Gln Val Gly Arg Ala Ala 
        355                 360                 365             


Ala Ala Leu Met Gln Asp Arg His Thr Ala Ala Gly Gln Leu Val Gln 
    370                 375                 380                 


Asp Leu Leu Thr Gln Val Arg Ala Gly Pro Glu Pro Gln Glu Leu Gln 
385                 390                 395                 400 


Gly Ile Arg Gln Ala Leu Ser Arg Ala Arg Ala Met Leu Ser Ala Glu 
                405                 410                 415     


Leu Gly Pro Glu Lys Leu Leu Ser Pro Lys Arg Leu Glu His Val Leu 
            420                 425                 430         


Glu Lys Ser Leu His Cys Ser Val Leu Lys Pro Leu Arg Pro Ile Leu 
        435                 440                 445             


Ala Ala Arg Leu Arg Arg Arg Leu Ala Ala Asp Gly Ser Leu Gly Arg 
    450                 455                 460                 


Leu Ala Glu Gly Leu Arg Leu Ala Arg Ala Gln Gly Pro Gly Ala Phe 
465                 470                 475                 480 


Gly Ser His Leu Ser Leu Pro Ser Pro Val Glu Leu Glu Gln Val Arg 
                485                 490                 495     


Gln Lys Leu Leu Gln Leu Leu Arg Thr Tyr Ser Pro Ser Ala Gln Val 
            500                 505                 510         


Lys Arg Leu Leu Gln Ala Cys Lys Leu Leu Tyr Met Ala Leu Arg Thr 
        515                 520                 525             


Gln Glu Gly Glu Gly Ala Gly Ala Asp Glu Phe Leu Pro Leu Leu Ser 
    530                 535                 540                 


Leu Val Leu Ala His Cys Asp Leu Pro Glu Leu Leu Leu Glu Ala Glu 
545                 550                 555                 560 


Tyr Met Ser Glu Leu Leu Glu Pro Ser Leu Leu Thr Gly Glu Gly Gly 
                565                 570                 575     


Tyr Tyr Leu Thr Ser Leu Ser Ala Ser Leu Ala Leu Leu Ser Gly Leu 
            580                 585                 590         


Gly Gln Ala His Thr Leu Pro Leu Ser Pro Val Gln Glu Leu Arg Arg 
        595                 600                 605             


Ser Leu Ser Leu Trp Glu Gln Arg Arg Leu Pro Ala Thr His Cys Phe 
    610                 615                 620                 


Gln His Leu Leu Arg Val Ala Tyr Gln Asp Pro Ser Ser Gly Cys Thr 
625                 630                 635                 640 


Ser Lys Thr Leu Ala Val Pro Pro Glu Ala Ser Ile Ala Thr Leu Asn 
                645                 650                 655     


Gln Leu Cys Ala Thr Lys Phe Arg Val Thr Gln Pro Asn Thr Phe Gly 
            660                 665                 670         


Leu Phe Leu Tyr Lys Glu Gln Gly Tyr His Arg Leu Pro Pro Gly Ala 
        675                 680                 685             


Leu Ala His Arg Leu Pro Thr Thr Gly Tyr Leu Val Tyr Arg Arg Ala 
    690                 695                 700                 


Glu Trp Pro Glu Thr Gln Gly Ala Val Thr Glu Glu Glu Gly Ser Gly 
705                 710                 715                 720 


Gln Ser Glu Ala Arg Ser Arg Gly Glu Glu Gln Gly Cys Gln Gly Asp 
                725                 730                 735     


Gly Asp Ala Gly Val Lys Ala Ser Pro Arg Asp Ile Arg Glu Gln Ser 
            740                 745                 750         


Glu Thr Thr Ala Glu Gly Gly Gln Gly Gln Ala Gln Glu Gly Pro Ala 
        755                 760                 765             


Gln Pro Gly Glu Pro Glu Ala Glu Gly Ser Arg Ala Ala Glu Glu 
    770                 775                 780             


<210>  2704
<211>  1360
<212>  DNA
<213>  Homosapiens

<400>  2704
aagcaccgat aggctctgcc tcccgaagaa aagggagccg cgcagcgcct acgggagtcc     60

ggcggcagca gccggtaccg gcaaccacgg gcagctctca gggaatctcc gtcgtgaggc    120

cagaggctcc agtccccgcg agtccagatg cctgtccagc ctccaagcaa agacacagaa    180

gagatggaag cagagggtga ttctgctgct gagatgaatg gggaggagga agagagtgag    240

gaggagcgga gcggcagcca gacagagtca gaagaggaga gctccgagat ggatgatgag    300

gactatgagc gacgccgcag cgagtgtgtc agtgagatgc tggacctaga gaagcagttc    360

tcggagctaa aggagaagtt gttcagggaa cgactgagtc agctgcggtt gcggctggag    420

gaagtggggg ctgagagagc ccctgaatac acggagcccc ttggggggct gcagcggagc    480

ctcaagattc gcattcaggt ggcagggatc tacaagggct tctgtctgga tgtgatcagg    540

aataagtacg aatgtgagct gcagggagcc aaacagcacc tggagagtga gaagctgctg    600

ctctatgaca cgctgcaggg ggagctgcag gagcggatcc agaggctgga ggaggaccgc    660

cagagcctgg acctcagctc tgaatggtgg gatgacaaac tgcacgccag aggcagctcc    720

aggtcttggg actccctgcc gcccagcaag aggaagaagg cacctctggt ttctggccca    780

tacatcgtgt acatgcttca agagatcgac atcctggagg actggacagc catcaaaaag    840

gctagggcag ctgtgtcccc tcagaagaga aaatcggatg acaggcggac ccacaggccc    900

ctcagggtct gcccagccag gctcctgtgg tgctgctggg ccctcccact ccatctggca    960

ctggcctgga ctcctcctct gccctcctcg aggcctgcac agctgtggcc gtggagctga   1020

cctgaccagg caaggctgct gtctccatcc ctgagccgcc tgccacctcc cactcctgaa   1080

gatccatctc ttggggctcc cctgacagag aagacagccg aagtcaaagc cacatcctct   1140

tgctgatgtt ggatgcaggc tgtccggcct cagggccagg gagccagttt ccactgtgcg   1200

ggaactctga gtcagacgtg attatctggg ggtctgtcca ccctggctgg atctggaggc   1260

aagatgccag gccccccagg tgttctcagg gcagttcttg gtgtctgctt ctcagattcc   1320

aaggactgga attaaaacct ttcctgggac tctggaaaaa                         1360


<210>  2705
<211>  290
<212>  PRT
<213>  Homosapiens

<400>  2705

Met Pro Val Gln Pro Pro Ser Lys Asp Thr Glu Glu Met Glu Ala Glu 
1               5                   10                  15      


Gly Asp Ser Ala Ala Glu Met Asn Gly Glu Glu Glu Glu Ser Glu Glu 
            20                  25                  30          


Glu Arg Ser Gly Ser Gln Thr Glu Ser Glu Glu Glu Ser Ser Glu Met 
        35                  40                  45              


Asp Asp Glu Asp Tyr Glu Arg Arg Arg Ser Glu Cys Val Ser Glu Met 
    50                  55                  60                  


Leu Asp Leu Glu Lys Gln Phe Ser Glu Leu Lys Glu Lys Leu Phe Arg 
65                  70                  75                  80  


Glu Arg Leu Ser Gln Leu Arg Leu Arg Leu Glu Glu Val Gly Ala Glu 
                85                  90                  95      


Arg Ala Pro Glu Tyr Thr Glu Pro Leu Gly Gly Leu Gln Arg Ser Leu 
            100                 105                 110         


Lys Ile Arg Ile Gln Val Ala Gly Ile Tyr Lys Gly Phe Cys Leu Asp 
        115                 120                 125             


Val Ile Arg Asn Lys Tyr Glu Cys Glu Leu Gln Gly Ala Lys Gln His 
    130                 135                 140                 


Leu Glu Ser Glu Lys Leu Leu Leu Tyr Asp Thr Leu Gln Gly Glu Leu 
145                 150                 155                 160 


Gln Glu Arg Ile Gln Arg Leu Glu Glu Asp Arg Gln Ser Leu Asp Leu 
                165                 170                 175     


Ser Ser Glu Trp Trp Asp Asp Lys Leu His Ala Arg Gly Ser Ser Arg 
            180                 185                 190         


Ser Trp Asp Ser Leu Pro Pro Ser Lys Arg Lys Lys Ala Pro Leu Val 
        195                 200                 205             


Ser Gly Pro Tyr Ile Val Tyr Met Leu Gln Glu Ile Asp Ile Leu Glu 
    210                 215                 220                 


Asp Trp Thr Ala Ile Lys Lys Ala Arg Ala Ala Val Ser Pro Gln Lys 
225                 230                 235                 240 


Arg Lys Ser Asp Asp Arg Arg Thr His Arg Pro Leu Arg Val Cys Pro 
                245                 250                 255     


Ala Arg Leu Leu Trp Cys Cys Trp Ala Leu Pro Leu His Leu Ala Leu 
            260                 265                 270         


Ala Trp Thr Pro Pro Leu Pro Ser Ser Arg Pro Ala Gln Leu Trp Pro 
        275                 280                 285             


Trp Ser 
    290 


<210>  2706
<211>  758
<212>  DNA
<213>  Homosapiens

<400>  2706
aagcaccgat aggctctgcc tcccgaagaa aagggagccg cgcagcgcct acgggagtcc     60

ggcggcagca gccggtaccg gcaaccacgg gcagctctca gggaatctcc gtcgtgaggc    120

cagaggctcc agtccccgcg agtccagatg cctgtccagc ctccaagcaa agacacagaa    180

gagatggaag cagagggtga ttctgctgct gagatgaatg gggaggagga agagagtgag    240

gaggagcgga gcggcagcca gacagagtca gaagaggaga gctccgagat ggatgatgag    300

gactatgagc gacgccgcag cgagtgtgtc agtgagatgc tggacctaga gaagcagttc    360

tcggagctaa aggagaagtt gttcagggaa cgactgagtc agctgcggtt gcggctggag    420

gaagtggggg ctgagagagc ccctgaatac acggagcccc ttggggggct gcagcggagc    480

ctcaagattc gcattcaggt ggcagggatc tacaagggct tctgtctgga tgtgatcagg    540

aataagtacg aatgtgagct gcagggagcc aaacagcact gtgcgggaac tctgagtcag    600

acgtgattat ctgggggtct gtccaccctg gctggatctg gaggcaagat gccaggcccc    660

ccaggtgttc tcagggcagt tcttggtgtc tgcttctcag attccaagga ctggaattaa    720

aacctttcct gggactctgg aaaaaaaaaa aaaaaaaa                            758


<210>  2707
<211>  152
<212>  PRT
<213>  Homosapiens

<400>  2707

Met Pro Val Gln Pro Pro Ser Lys Asp Thr Glu Glu Met Glu Ala Glu 
1               5                   10                  15      


Gly Asp Ser Ala Ala Glu Met Asn Gly Glu Glu Glu Glu Ser Glu Glu 
            20                  25                  30          


Glu Arg Ser Gly Ser Gln Thr Glu Ser Glu Glu Glu Ser Ser Glu Met 
        35                  40                  45              


Asp Asp Glu Asp Tyr Glu Arg Arg Arg Ser Glu Cys Val Ser Glu Met 
    50                  55                  60                  


Leu Asp Leu Glu Lys Gln Phe Ser Glu Leu Lys Glu Lys Leu Phe Arg 
65                  70                  75                  80  


Glu Arg Leu Ser Gln Leu Arg Leu Arg Leu Glu Glu Val Gly Ala Glu 
                85                  90                  95      


Arg Ala Pro Glu Tyr Thr Glu Pro Leu Gly Gly Leu Gln Arg Ser Leu 
            100                 105                 110         


Lys Ile Arg Ile Gln Val Ala Gly Ile Tyr Lys Gly Phe Cys Leu Asp 
        115                 120                 125             


Val Ile Arg Asn Lys Tyr Glu Cys Glu Leu Gln Gly Ala Lys Gln His 
    130                 135                 140                 


Cys Ala Gly Thr Leu Ser Gln Thr 
145                 150         


<210>  2708
<211>  1455
<212>  DNA
<213>  Homosapiens

<400>  2708
aagcaccgat aggctctgcc tcccgaagaa aagggagccg cgcagcgcct acgggagtcc     60

ggcggcagca gccggtaccg gcaaccacgg gcagctctca gggaatctcc gtcgtgaggc    120

cagaggctcc agtccccgcg agtccagatg cctgtccagc ctccaagcaa agacacagaa    180

gagatggaag cagagggtga ttctgctgct gagatgaatg gggaggagga agagagtgag    240

gaggagcgga gcggcagcca gacagagtca gaagaggaga gctccgagat ggatgatgag    300

gactatgagc gacgccgcag cgagtgtgtc agtgagatgc tggacctaga gaagcagttc    360

tcggagctaa aggagaagtt gttcagggaa cgactgagtc agctgcggtt gcggctggag    420

gaagtggggg ctgagagagc ccctgaatac acggagcccc ttggggggct gcagcggagc    480

ctcaagattc gcattcaggt ggcagggatc tacaagggct tctgtctgga tgtgatcagg    540

aataagtacg aatgtgagct gcagggagcc aaacagcacc tggagagtga gaagctgctg    600

ctctatgaca cgctgcaggg ggagctgcag gagcggatcc agaggctgga ggaggaccgc    660

cagagcctgg acctcagctc tgaatggtgg gatgacaaac tgcacgccag aggcagctcc    720

aggtcttggg actccctgcc gcccagcaag aggaagaagg cacctctggt ttctggccca    780

tacatcgtgt acatgcttca agagatcgac atcctggagg actggacagc catcaaaaag    840

gctagggcag ctgtgtcccc tcagaagaga aaatcggatg gaccttgacc ctgctgttca    900

cagccagggg gaccctcaga gcagctggca ctgcacccag gattctcgtc ttcctcctgc    960

agacaggcgg acccacaggc ccctcagggt ctgcccagcc aggctcctgt ggtgctgctg   1020

ggccctccca ctccatctgg cactggcctg gactcctcct ctgccctcct cgaggcctgc   1080

acagctgtgg ccgtggagct gacctgacca ggcaaggctg ctgtctccat ccctgagccg   1140

cctgccacct cccactcctg aagatccatc tcttggggct cccctgacag agaagacagc   1200

cgaagtcaaa gccacatcct cttgctgatg ttggatgcag gctgtccggc ctcagggcca   1260

gggagccagt ttccactgtg cgggaactct gagtcagacg tgattatctg ggggtctgtc   1320

caccctggct ggatctggag gcaagatgcc aggcccccca ggtgttctca gggcagttct   1380

tggtgtctgc ttctcagatt ccaaggactg gaattaaaac ctttcctggg actctggaaa   1440

aaaaaaaaaa aaaaa                                                    1455


<210>  2709
<211>  246
<212>  PRT
<213>  Homosapiens

<400>  2709

Met Pro Val Gln Pro Pro Ser Lys Asp Thr Glu Glu Met Glu Ala Glu 
1               5                   10                  15      


Gly Asp Ser Ala Ala Glu Met Asn Gly Glu Glu Glu Glu Ser Glu Glu 
            20                  25                  30          


Glu Arg Ser Gly Ser Gln Thr Glu Ser Glu Glu Glu Ser Ser Glu Met 
        35                  40                  45              


Asp Asp Glu Asp Tyr Glu Arg Arg Arg Ser Glu Cys Val Ser Glu Met 
    50                  55                  60                  


Leu Asp Leu Glu Lys Gln Phe Ser Glu Leu Lys Glu Lys Leu Phe Arg 
65                  70                  75                  80  


Glu Arg Leu Ser Gln Leu Arg Leu Arg Leu Glu Glu Val Gly Ala Glu 
                85                  90                  95      


Arg Ala Pro Glu Tyr Thr Glu Pro Leu Gly Gly Leu Gln Arg Ser Leu 
            100                 105                 110         


Lys Ile Arg Ile Gln Val Ala Gly Ile Tyr Lys Gly Phe Cys Leu Asp 
        115                 120                 125             


Val Ile Arg Asn Lys Tyr Glu Cys Glu Leu Gln Gly Ala Lys Gln His 
    130                 135                 140                 


Leu Glu Ser Glu Lys Leu Leu Leu Tyr Asp Thr Leu Gln Gly Glu Leu 
145                 150                 155                 160 


Gln Glu Arg Ile Gln Arg Leu Glu Glu Asp Arg Gln Ser Leu Asp Leu 
                165                 170                 175     


Ser Ser Glu Trp Trp Asp Asp Lys Leu His Ala Arg Gly Ser Ser Arg 
            180                 185                 190         


Ser Trp Asp Ser Leu Pro Pro Ser Lys Arg Lys Lys Ala Pro Leu Val 
        195                 200                 205             


Ser Gly Pro Tyr Ile Val Tyr Met Leu Gln Glu Ile Asp Ile Leu Glu 
    210                 215                 220                 


Asp Trp Thr Ala Ile Lys Lys Ala Arg Ala Ala Val Ser Pro Gln Lys 
225                 230                 235                 240 


Arg Lys Ser Asp Gly Pro 
                245     


<210>  2710
<211>  2077
<212>  DNA
<213>  Homosapiens

<400>  2710
gcggcgggcg gggcggcgct cggggctcgg ctggcctcgg ctcgcctcgg ctgcgctcgg     60

caggctgcgg taaatccggg cttgcggccg ctggcgtagt ctgtggccgg gtggtcgttg    120

ctgcgcgccc cgagccccga gagccatgca gatgtcctac gccatccggt gcgccttcta    180

ccagctgctg ctggccgcgc tcatgctggt ggcgatgctg cagctgctct acctgtcgct    240

gctgtccgga ctgcacgggc aggaggagca agaccaatat tttgagttct ttcccccgtc    300

cccacggtcc gtggaccagg tcaaggcgca gctccgcacc gcgctggcct ctggaggcgt    360

cctggacgct agcggcgatt accgcgtcta caggggcctg ctgaagacca ccatggaccc    420

caacgatgtg atcctggcca cgcacgccag cgtggacaac ctgctgcacc tgtcgggtct    480

gctggagcgc tgggagggcc cgctgtccgt gtcggtgttc gcggccacca aggaggaggc    540

gcagctggcc acggtgctgg cctacgcgct gagcagccac tgccccgaca tgcgcgccag    600

ggtcgccatg cacctcgtgt gcccctcgcg ttacgaggca gccgtgcccg acccccggga    660

gccgggggag tttgccctgc tgcggtcctg ccaggaggtc tttgacaagc tagccagggt    720

ggcccagccc gggattaatt atgcgctggg caccaatgtc tcctacccca ataacctgct    780

gaggaatctg gctcgtgagg gggccaacta tgccctggtg atcgatgtgg acatggtgcc    840

cagcgagggg ctgtggagag gcctgcggga aatgctggat cagagcaacc agtggggagg    900

caccgcgctg gtggtgcctg ccttcgaaat ccgaagagcc cgccgcatgc ccatgaacaa    960

aaacgagctg gtgcagctct accaggttgg cgaggtgcgg cccttctatt atgggttgtg   1020

caccccctgc caggcaccca ccaactattc ccgctgggtc aacctgccgg aagagagctt   1080

gctgcggccc gcctacgtgg taccttggca ggacccctgg gagccattct acgtggcagg   1140

aggcaaggtg cccaccttcg acgagcgctt tcggcagtac ggcttcaacc gaatcagcca   1200

ggcctgcgag ctgcatgtgg cggggtttga ttttgaggtc ctgaacgaag gtttcttggt   1260

tcataagggc ttcaaagaag cgttgaagtt ccatccccaa aaggaggctg aaaatcagca   1320

caataagatc ctatatcgcc agttcaaaca ggagttgaag gccaagtacc ccaactctcc   1380

ccgacgctgc tgagcccttc cctcccctaa tctgagaagt cagcctcttg gctcctcagg   1440

ccaccattta ggcctgactg gggtaagaaa tgtcgctcca ctttacagag gtagctgtgg   1500

tgttgaaaca ctggacttgg atatggggtg ctgggatcga ttcctagctt taccactaac   1560

tagctgtgtg gccttgagta aatcccgtta cctctctgag cctcggttac cctgtctgta   1620

aaaagggagg tgagaatacc tacctcacgg aactgttggg aggctcagat gagatgctat   1680

atgtgaaaac attctgtaag cttcgtacaa atgtgaagta ttaatattat cgcagtatta   1740

ttgttgttat tattattgtt attattaaca atcttgggtg ggtagtagga gagcaaaaag   1800

tatgaatggg atggagctaa gaagtctgaa tacttaatga aatggacttt ttggaaagaa   1860

atcagatgaa ggcataaaat ttagttctta gctcttgaac agaagcctaa aattcctggt   1920

tctctcaggg cttcgccttc aagggttctg gaggagggaa gggtctgcag gttccatggg   1980

tgacagcctg agatctgtcc cttcaacggg ctgggctggg tatgtgccta ccgatgacaa   2040

tgtgtaaata aatgcgtgtt cacacccaca aaaaaaa                            2077


<210>  2711
<211>  415
<212>  PRT
<213>  Homosapiens

<400>  2711

Met Gln Met Ser Tyr Ala Ile Arg Cys Ala Phe Tyr Gln Leu Leu Leu 
1               5                   10                  15      


Ala Ala Leu Met Leu Val Ala Met Leu Gln Leu Leu Tyr Leu Ser Leu 
            20                  25                  30          


Leu Ser Gly Leu His Gly Gln Glu Glu Gln Asp Gln Tyr Phe Glu Phe 
        35                  40                  45              


Phe Pro Pro Ser Pro Arg Ser Val Asp Gln Val Lys Ala Gln Leu Arg 
    50                  55                  60                  


Thr Ala Leu Ala Ser Gly Gly Val Leu Asp Ala Ser Gly Asp Tyr Arg 
65                  70                  75                  80  


Val Tyr Arg Gly Leu Leu Lys Thr Thr Met Asp Pro Asn Asp Val Ile 
                85                  90                  95      


Leu Ala Thr His Ala Ser Val Asp Asn Leu Leu His Leu Ser Gly Leu 
            100                 105                 110         


Leu Glu Arg Trp Glu Gly Pro Leu Ser Val Ser Val Phe Ala Ala Thr 
        115                 120                 125             


Lys Glu Glu Ala Gln Leu Ala Thr Val Leu Ala Tyr Ala Leu Ser Ser 
    130                 135                 140                 


His Cys Pro Asp Met Arg Ala Arg Val Ala Met His Leu Val Cys Pro 
145                 150                 155                 160 


Ser Arg Tyr Glu Ala Ala Val Pro Asp Pro Arg Glu Pro Gly Glu Phe 
                165                 170                 175     


Ala Leu Leu Arg Ser Cys Gln Glu Val Phe Asp Lys Leu Ala Arg Val 
            180                 185                 190         


Ala Gln Pro Gly Ile Asn Tyr Ala Leu Gly Thr Asn Val Ser Tyr Pro 
        195                 200                 205             


Asn Asn Leu Leu Arg Asn Leu Ala Arg Glu Gly Ala Asn Tyr Ala Leu 
    210                 215                 220                 


Val Ile Asp Val Asp Met Val Pro Ser Glu Gly Leu Trp Arg Gly Leu 
225                 230                 235                 240 


Arg Glu Met Leu Asp Gln Ser Asn Gln Trp Gly Gly Thr Ala Leu Val 
                245                 250                 255     


Val Pro Ala Phe Glu Ile Arg Arg Ala Arg Arg Met Pro Met Asn Lys 
            260                 265                 270         


Asn Glu Leu Val Gln Leu Tyr Gln Val Gly Glu Val Arg Pro Phe Tyr 
        275                 280                 285             


Tyr Gly Leu Cys Thr Pro Cys Gln Ala Pro Thr Asn Tyr Ser Arg Trp 
    290                 295                 300                 


Val Asn Leu Pro Glu Glu Ser Leu Leu Arg Pro Ala Tyr Val Val Pro 
305                 310                 315                 320 


Trp Gln Asp Pro Trp Glu Pro Phe Tyr Val Ala Gly Gly Lys Val Pro 
                325                 330                 335     


Thr Phe Asp Glu Arg Phe Arg Gln Tyr Gly Phe Asn Arg Ile Ser Gln 
            340                 345                 350         


Ala Cys Glu Leu His Val Ala Gly Phe Asp Phe Glu Val Leu Asn Glu 
        355                 360                 365             


Gly Phe Leu Val His Lys Gly Phe Lys Glu Ala Leu Lys Phe His Pro 
    370                 375                 380                 


Gln Lys Glu Ala Glu Asn Gln His Asn Lys Ile Leu Tyr Arg Gln Phe 
385                 390                 395                 400 


Lys Gln Glu Leu Lys Ala Lys Tyr Pro Asn Ser Pro Arg Arg Cys 
                405                 410                 415 


<210>  2712
<211>  2529
<212>  DNA
<213>  Homosapiens

<400>  2712
ggtggcgcga ccctctgtcc ccgcctcggg gcggagccca ggtcccagcc tgcggagcgc     60

gagacacgcc gaaatccgcc cgaggctacc tgtgcgactc cagccgccct gcaccggaat    120

ctggggagac ccgccccccg ccccaccggt ctgcggccct ccgccccagc gcaggtgcag    180

gtgcggcttc tctgcccctt tcaccccagg cgcatccgcc gcggcggcca tggcgcgagg    240

agacgccccg cgggacagct accacctggt cgggatcagc ttcttcatcc tggggctggg    300

caccctcctt ccctggaact tcttcatcac cgccatcccg tacttccagg cgcgactggc    360

cggggccggc aacagcacag ccaggatcct gagcaccaac cacacgggtc ccgaggatgc    420

cttcaacttc aacaattggg tgacgctgct gtcccagctg cccctgctgc tcttcaccct    480

cctcaactcc ttcctgtacc agtgcgtccc ggagacggtg cgcattctgg gcagcctgct    540

ggccatactg ctgctctttg ccctgacagc agcgctggtc aaggtggaca tgagccccgg    600

acccttcttc tccatcacca tggcctccgt ctgcttcatc aactccttca gtgcagtcct    660

acagggcagc ctcttcgggc agctgggcac catgccctcc acctacagca ccctcttcct    720

cagcggccag ggcctggctg ggatctttgc tgcccttgcc atgctcctgt ccatggccag    780

tggcgtggac gccgagacct ctgccctggg gtactttatc acgccctgtg tgggcatcct    840

catgtccatc gtgtgttacc tgagcctgcc tcacctgaag tttgcccgct actacctggc    900

caataaatca tcccaggccc aagctcagga gctggagacc aaagctgagc tcctccagtc    960

tgatgagaac gggattccca gtagtcccca gaaagtagct ctgaccctgg atcttgacct   1020

ggagaaggag ccggaatcag agccagatga gccccagaag ccaggaaaac cttcagtctt   1080

cactgtcttc cagaagatct ggctgacagc gctgtgcctt gtgttggtct tcacagtcac   1140

cctgtccgtc ttccccgcca tcacagccat ggtgaccagc tccaccagtc ctgggaagtg   1200

gagtcagttc ttcaacccca tctgctgctt cctcctcttc aacatcatgg actggctggg   1260

acggagcctg acctcttact tcctgtggcc agacgaggac agccggctgc tgcccctgct   1320

ggtctgcctg cggttcctgt tcgtgcccct cttcatgctg tgccacgtgc cccagaggtc   1380

ccggctgccc atcctcttcc cacaggatgc ctacttcatc accttcatgc tgctctttgc   1440

cgtttctaat ggctacctgg tgtccctcac catgtgcctg gcgcccaggc aggtgctgcc   1500

acacgagagg gaggtggccg gcgccctcat gaccttcttc ctggccctgg gactttcctg   1560

tggagcctcc ctctccttcc tcttcaaggc gctgctctga agtggcccct ccaggctctt   1620

tggcagcctc ttctcgacgt ctccttccgg agctgagatc cagcccaggg cgaatggcga   1680

gcttggctca ggcctctgcg gggtggaggc ccctgggcct gaggctgcca gcagcgggca   1740

ggagctgctc ttcatccact tggagtgctg cggggaagaa atcaccaccg gtcattctaa   1800

ccctcaccca ggaatggggg tgactcgcac aagacctcat ggaaagggtg atgactaggg   1860

aaaagagggt gcagggcacg gctgctcccc accaccaggt ctgcatttgt tcatcatcat   1920

caggagcaga ggtgaccaga gggttcagag tgggaggcgg ggccagccca ggccaggagc   1980

gcctcatctt cccaggcctc agccacccag ggtaaaaggt gccagggaag ttgtgggcac   2040

ctgagaggag gaacagatgt ggaggacctg agggtgctca aagggccagg ctcagcctca   2100

agcagtgttt tcattgccaa cacttactgt acccactccg cagagcccag ctgggcctgg   2160

gccccagggc cacagctagc ctgcatgtgt gtactgcact ttacagtttg caaagctctt   2220

ccatacccac tctctcaccg aagcctaatt gaggctcttg gaaggagtca ggcaaggatt   2280

gtgcttcccc cattatacag gtgacaaaac tgagtcctgg ggaaagtgac tggtccgtgg   2340

tagagccggg acccaatccc ctctctctcc tccctgttgg tgctgttctt cctgcccaac   2400

acctgtttct cttttcctca aggggtttgg ggcaggagcc tgggcactta ctccccgttt   2460

ttgctgtttc tccttctgac cctgctcttg ggtctaataa ccccatttat ttgtaaaaaa   2520

aaaaaaaaa                                                           2529


<210>  2713
<211>  456
<212>  PRT
<213>  Homosapiens

<400>  2713

Met Ala Arg Gly Asp Ala Pro Arg Asp Ser Tyr His Leu Val Gly Ile 
1               5                   10                  15      


Ser Phe Phe Ile Leu Gly Leu Gly Thr Leu Leu Pro Trp Asn Phe Phe 
            20                  25                  30          


Ile Thr Ala Ile Pro Tyr Phe Gln Ala Arg Leu Ala Gly Ala Gly Asn 
        35                  40                  45              


Ser Thr Ala Arg Ile Leu Ser Thr Asn His Thr Gly Pro Glu Asp Ala 
    50                  55                  60                  


Phe Asn Phe Asn Asn Trp Val Thr Leu Leu Ser Gln Leu Pro Leu Leu 
65                  70                  75                  80  


Leu Phe Thr Leu Leu Asn Ser Phe Leu Tyr Gln Cys Val Pro Glu Thr 
                85                  90                  95      


Val Arg Ile Leu Gly Ser Leu Leu Ala Ile Leu Leu Leu Phe Ala Leu 
            100                 105                 110         


Thr Ala Ala Leu Val Lys Val Asp Met Ser Pro Gly Pro Phe Phe Ser 
        115                 120                 125             


Ile Thr Met Ala Ser Val Cys Phe Ile Asn Ser Phe Ser Ala Val Leu 
    130                 135                 140                 


Gln Gly Ser Leu Phe Gly Gln Leu Gly Thr Met Pro Ser Thr Tyr Ser 
145                 150                 155                 160 


Thr Leu Phe Leu Ser Gly Gln Gly Leu Ala Gly Ile Phe Ala Ala Leu 
                165                 170                 175     


Ala Met Leu Leu Ser Met Ala Ser Gly Val Asp Ala Glu Thr Ser Ala 
            180                 185                 190         


Leu Gly Tyr Phe Ile Thr Pro Cys Val Gly Ile Leu Met Ser Ile Val 
        195                 200                 205             


Cys Tyr Leu Ser Leu Pro His Leu Lys Phe Ala Arg Tyr Tyr Leu Ala 
    210                 215                 220                 


Asn Lys Ser Ser Gln Ala Gln Ala Gln Glu Leu Glu Thr Lys Ala Glu 
225                 230                 235                 240 


Leu Leu Gln Ser Asp Glu Asn Gly Ile Pro Ser Ser Pro Gln Lys Val 
                245                 250                 255     


Ala Leu Thr Leu Asp Leu Asp Leu Glu Lys Glu Pro Glu Ser Glu Pro 
            260                 265                 270         


Asp Glu Pro Gln Lys Pro Gly Lys Pro Ser Val Phe Thr Val Phe Gln 
        275                 280                 285             


Lys Ile Trp Leu Thr Ala Leu Cys Leu Val Leu Val Phe Thr Val Thr 
    290                 295                 300                 


Leu Ser Val Phe Pro Ala Ile Thr Ala Met Val Thr Ser Ser Thr Ser 
305                 310                 315                 320 


Pro Gly Lys Trp Ser Gln Phe Phe Asn Pro Ile Cys Cys Phe Leu Leu 
                325                 330                 335     


Phe Asn Ile Met Asp Trp Leu Gly Arg Ser Leu Thr Ser Tyr Phe Leu 
            340                 345                 350         


Trp Pro Asp Glu Asp Ser Arg Leu Leu Pro Leu Leu Val Cys Leu Arg 
        355                 360                 365             


Phe Leu Phe Val Pro Leu Phe Met Leu Cys His Val Pro Gln Arg Ser 
    370                 375                 380                 


Arg Leu Pro Ile Leu Phe Pro Gln Asp Ala Tyr Phe Ile Thr Phe Met 
385                 390                 395                 400 


Leu Leu Phe Ala Val Ser Asn Gly Tyr Leu Val Ser Leu Thr Met Cys 
                405                 410                 415     


Leu Ala Pro Arg Gln Val Leu Pro His Glu Arg Glu Val Ala Gly Ala 
            420                 425                 430         


Leu Met Thr Phe Phe Leu Ala Leu Gly Leu Ser Cys Gly Ala Ser Leu 
        435                 440                 445             


Ser Phe Leu Phe Lys Ala Leu Leu 
    450                 455     


<210>  2714
<211>  3302
<212>  DNA
<213>  Homosapiens

<400>  2714
gctatataag gcggcgtgag gcaggcgagg ggggcagcgc agccgagcgg agcccaggag     60

agcagagagc gagcctgagc gagagacggg gaagcacgga ggaggaagcc gccggtgcgt    120

cgggacggga gcgcaggtgc tcgggcaccc gagctggagc tccgcagccg ccggtcatgt    180

accgctccac caagggcgcc tccaaggcgc gccgggacca gatcaacgcc gagatccgga    240

acctcaagga gctgctgccg ctggccgaag cggacaaggt ccggctgtcc tacctgcaca    300

tcatgagcct cgcctgcatc tacactcgca agggcgtctt cttcgctggt ggcactcctc    360

tggcgggccc cacggggctt ctctcagctc gagagcttga ggacatcgta gcggcactac    420

ccggctttct gcttgtgttc acagccgagg ggaaattgct ctacctgtct aagagtgtga    480

gcgagcatct gggccactcc atggtggacc tggttgccca gggtgacagc atctacgaca    540

tcattgaccc agctgaccac ctcactgtgc gccagcaact caccctgccc tctgccctgg    600

acactgatcg cctcttccgc tgccgcttca acacctccaa gtccctcagg cgccagagtg    660

caggcaacaa actcgtgctt attcgaggcc gattccatgc tcacccacct ggagcctact    720

gggcaggaaa tcccgtgttc acagctttct gtgcccctct ggagccgaga ccccgcccag    780

gtcctggccc tggccctggc cctgcctcgc tcttcctggc catgttccag agccgccatg    840

ctaaagacct ggctctactg gacatctccg agagtgtcct aatctacctg ggctttgagc    900

gcagtgaact gctttgtaaa tcatggtatg gactgctgca ccccgaggac ctggcccacg    960

cttctgctca acactaccgc ctgttggctg agagtggaga tattcaggca gagatggtgg   1020

tgaggctaca ggccaagact ggaggctggg catggattta ctgcctgtta tactcagaag   1080

gtccagaggg acccattact gccaataact acccaatcag tgacatggaa gcctggagcc   1140

tccgccagca gttgaactct gaagacaccc aggcagctta tgtcctgggc actccgacca   1200

tgctgccctc attccctgaa aacattcttt cccaggaaga gtgctccagc actaacccac   1260

tcttcaccgc agcactgggg gctcccagaa gcaccagctt ccccagtgct cctgaactga   1320

gtgttgtctc tgcatcagaa gagcatcccc gaccctccaa agaactggac ttcagttacc   1380

tgacattccc ttctgggcct gagccttctc tccaagcaga actaagcaag gatcttgtgt   1440

gcactccacc ttacacgccc catcagccag gaggctgtgc cttcctcttc agcctccatg   1500

agcccttcca gacccatttg cccaccccat ccagcactct tcaagaacag ctgactccaa   1560

gcactgcgac cttctctgat cagttgacgc ccagcagtgc aaccttccca gatccactaa   1620

ctagcccact gcaaggccag ttgactgaaa cctcggtcag aagctatgaa gaccagttga   1680

ctccctgcac ctccaccttc ccagaccagc tgcttcccag cacagccacc ttcccagagc   1740

ctctgggcag ccctgcccat gaacagctga ctcctcccag cacagcattc caagcacacc   1800

tggacagccc cagccaaacc ttcccagagc aactgagccc caaccctacc aagacttact   1860

ttgcccagga gggatgcagt tttctctatg agaagttgcc cccaagtcct agcagccctg   1920

gtaatgggga ctgcacgctc ttggccctag cccagctccg gggccccctc tctgtggatg   1980

tccccctggt gcccgaaggc ctgctcacac ctgaggcctc tccagtcaag cagagtttct   2040

tccactactc tgaaaaggag cagaatgaga tagaccgtct catccagcag attagccaat   2100

tggctcaggg catggacaga cccttctcag ctgaggctgg cactggcgga ctagagccac   2160

ttggaggact ggagcccctg gactccaacc tgtccctgtc aggggcaggc ccccctgtgc   2220

tcagcctgga cctgaaaccc tggaaatgcc aggagctgga cttcctggct gaccctgata   2280

acatgttcct ggaagagacg cccgtggaag acatcttcat ggatctctct accccagatc   2340

ccagtgagga atggggctca ggggatcctg aggcagaggg cccaggaggg gccccatcgc   2400

cttgcaacaa cctgtcccca gaagaccaca gcttcctgga ggacctggcc acatatgaaa   2460

ccgcctttga gacaggtgtc tcagcattcc cctatgatgg gtttactgat gagttgcatc   2520

aactccagag ccaagttcaa gacagcttcc atgaagatgg aagtggaggg gaaccaacgt   2580

tttgaataag tctgtgactt aacgtcgtca agtatggcat attgtcatca agacgtggag   2640

ccgctctcca cccccccggg actgttgggg ggattctgag ggccagaggg ggatatatat   2700

gattccccag gccctgcagg attttggggg gggggaggtg ggagggcaag ggaggggagc   2760

ttctttttaa aatcaagaga cttcgagcga tcccagtttc catttcaatc tgtattcact   2820

cgtagtgagt ttccttgaat gggatttcaa gcggagaatg ggggagtctc acttccccgc   2880

cgccttgccc cattggcctg ggccagttct ccactcctag gggccaagcc acccctagcc   2940

ttggtggggg aaaggcaggg cccacccggg ccagcccgtg ccctgagggg ctcttgacac   3000

ccacgtagaa ttctctacac accagtaacg ggatttcaat tccgatggac tctgccgccc   3060

tggcggccct tcctgtgact tttgcgcccc tcgcctgggg tggggggtgc gaagagacgc   3120

tacgttcctt tccgatggag gaaggcagac ctgccgtcac acgtgtgctt gcacgagtgc   3180

gtgtacctgg tgcgggactc acccggccgc cagactgcct gggcctgccc agatggccac   3240

ctcgtggtgc tgcggtgact ttgtagccaa ctttataata aagtccagtt tgcctttttg   3300

gt                                                                  3302


<210>  2715
<211>  802
<212>  PRT
<213>  Homosapiens

<400>  2715

Met Tyr Arg Ser Thr Lys Gly Ala Ser Lys Ala Arg Arg Asp Gln Ile 
1               5                   10                  15      


Asn Ala Glu Ile Arg Asn Leu Lys Glu Leu Leu Pro Leu Ala Glu Ala 
            20                  25                  30          


Asp Lys Val Arg Leu Ser Tyr Leu His Ile Met Ser Leu Ala Cys Ile 
        35                  40                  45              


Tyr Thr Arg Lys Gly Val Phe Phe Ala Gly Gly Thr Pro Leu Ala Gly 
    50                  55                  60                  


Pro Thr Gly Leu Leu Ser Ala Arg Glu Leu Glu Asp Ile Val Ala Ala 
65                  70                  75                  80  


Leu Pro Gly Phe Leu Leu Val Phe Thr Ala Glu Gly Lys Leu Leu Tyr 
                85                  90                  95      


Leu Ser Lys Ser Val Ser Glu His Leu Gly His Ser Met Val Asp Leu 
            100                 105                 110         


Val Ala Gln Gly Asp Ser Ile Tyr Asp Ile Ile Asp Pro Ala Asp His 
        115                 120                 125             


Leu Thr Val Arg Gln Gln Leu Thr Leu Pro Ser Ala Leu Asp Thr Asp 
    130                 135                 140                 


Arg Leu Phe Arg Cys Arg Phe Asn Thr Ser Lys Ser Leu Arg Arg Gln 
145                 150                 155                 160 


Ser Ala Gly Asn Lys Leu Val Leu Ile Arg Gly Arg Phe His Ala His 
                165                 170                 175     


Pro Pro Gly Ala Tyr Trp Ala Gly Asn Pro Val Phe Thr Ala Phe Cys 
            180                 185                 190         


Ala Pro Leu Glu Pro Arg Pro Arg Pro Gly Pro Gly Pro Gly Pro Gly 
        195                 200                 205             


Pro Ala Ser Leu Phe Leu Ala Met Phe Gln Ser Arg His Ala Lys Asp 
    210                 215                 220                 


Leu Ala Leu Leu Asp Ile Ser Glu Ser Val Leu Ile Tyr Leu Gly Phe 
225                 230                 235                 240 


Glu Arg Ser Glu Leu Leu Cys Lys Ser Trp Tyr Gly Leu Leu His Pro 
                245                 250                 255     


Glu Asp Leu Ala His Ala Ser Ala Gln His Tyr Arg Leu Leu Ala Glu 
            260                 265                 270         


Ser Gly Asp Ile Gln Ala Glu Met Val Val Arg Leu Gln Ala Lys Thr 
        275                 280                 285             


Gly Gly Trp Ala Trp Ile Tyr Cys Leu Leu Tyr Ser Glu Gly Pro Glu 
    290                 295                 300                 


Gly Pro Ile Thr Ala Asn Asn Tyr Pro Ile Ser Asp Met Glu Ala Trp 
305                 310                 315                 320 


Ser Leu Arg Gln Gln Leu Asn Ser Glu Asp Thr Gln Ala Ala Tyr Val 
                325                 330                 335     


Leu Gly Thr Pro Thr Met Leu Pro Ser Phe Pro Glu Asn Ile Leu Ser 
            340                 345                 350         


Gln Glu Glu Cys Ser Ser Thr Asn Pro Leu Phe Thr Ala Ala Leu Gly 
        355                 360                 365             


Ala Pro Arg Ser Thr Ser Phe Pro Ser Ala Pro Glu Leu Ser Val Val 
    370                 375                 380                 


Ser Ala Ser Glu Glu His Pro Arg Pro Ser Lys Glu Leu Asp Phe Ser 
385                 390                 395                 400 


Tyr Leu Thr Phe Pro Ser Gly Pro Glu Pro Ser Leu Gln Ala Glu Leu 
                405                 410                 415     


Ser Lys Asp Leu Val Cys Thr Pro Pro Tyr Thr Pro His Gln Pro Gly 
            420                 425                 430         


Gly Cys Ala Phe Leu Phe Ser Leu His Glu Pro Phe Gln Thr His Leu 
        435                 440                 445             


Pro Thr Pro Ser Ser Thr Leu Gln Glu Gln Leu Thr Pro Ser Thr Ala 
    450                 455                 460                 


Thr Phe Ser Asp Gln Leu Thr Pro Ser Ser Ala Thr Phe Pro Asp Pro 
465                 470                 475                 480 


Leu Thr Ser Pro Leu Gln Gly Gln Leu Thr Glu Thr Ser Val Arg Ser 
                485                 490                 495     


Tyr Glu Asp Gln Leu Thr Pro Cys Thr Ser Thr Phe Pro Asp Gln Leu 
            500                 505                 510         


Leu Pro Ser Thr Ala Thr Phe Pro Glu Pro Leu Gly Ser Pro Ala His 
        515                 520                 525             


Glu Gln Leu Thr Pro Pro Ser Thr Ala Phe Gln Ala His Leu Asp Ser 
    530                 535                 540                 


Pro Ser Gln Thr Phe Pro Glu Gln Leu Ser Pro Asn Pro Thr Lys Thr 
545                 550                 555                 560 


Tyr Phe Ala Gln Glu Gly Cys Ser Phe Leu Tyr Glu Lys Leu Pro Pro 
                565                 570                 575     


Ser Pro Ser Ser Pro Gly Asn Gly Asp Cys Thr Leu Leu Ala Leu Ala 
            580                 585                 590         


Gln Leu Arg Gly Pro Leu Ser Val Asp Val Pro Leu Val Pro Glu Gly 
        595                 600                 605             


Leu Leu Thr Pro Glu Ala Ser Pro Val Lys Gln Ser Phe Phe His Tyr 
    610                 615                 620                 


Ser Glu Lys Glu Gln Asn Glu Ile Asp Arg Leu Ile Gln Gln Ile Ser 
625                 630                 635                 640 


Gln Leu Ala Gln Gly Met Asp Arg Pro Phe Ser Ala Glu Ala Gly Thr 
                645                 650                 655     


Gly Gly Leu Glu Pro Leu Gly Gly Leu Glu Pro Leu Asp Ser Asn Leu 
            660                 665                 670         


Ser Leu Ser Gly Ala Gly Pro Pro Val Leu Ser Leu Asp Leu Lys Pro 
        675                 680                 685             


Trp Lys Cys Gln Glu Leu Asp Phe Leu Ala Asp Pro Asp Asn Met Phe 
    690                 695                 700                 


Leu Glu Glu Thr Pro Val Glu Asp Ile Phe Met Asp Leu Ser Thr Pro 
705                 710                 715                 720 


Asp Pro Ser Glu Glu Trp Gly Ser Gly Asp Pro Glu Ala Glu Gly Pro 
                725                 730                 735     


Gly Gly Ala Pro Ser Pro Cys Asn Asn Leu Ser Pro Glu Asp His Ser 
            740                 745                 750         


Phe Leu Glu Asp Leu Ala Thr Tyr Glu Thr Ala Phe Glu Thr Gly Val 
        755                 760                 765             


Ser Ala Phe Pro Tyr Asp Gly Phe Thr Asp Glu Leu His Gln Leu Gln 
    770                 775                 780                 


Ser Gln Val Gln Asp Ser Phe His Glu Asp Gly Ser Gly Gly Glu Pro 
785                 790                 795                 800 


Thr Phe 
        


<210>  2716
<211>  840
<212>  DNA
<213>  Homosapiens

<400>  2716
ctctggccca agatggtggc gcccagagct tcgctcttgc tgctcccctg aggtgaactg     60

aagccagcag ccccgcatca tgtcaaagct cggccgggcc gcccggggcc tcaggaagcc    120

cgaggtcggc ggtgtgatcc gggcgatcgt gcgggcaggc ctggccatgc ccgggccccc    180

actaggccca gtgctgggtc agagaggcgt ttccatcaac cagttttgca aggagttcaa    240

tgagaggaca aaggacatca aggaaggcat tcctctgcct accaagattt tagtgaagcc    300

tgacaggaca tttgaaatta agattggaca gcccactgtt tcctacttcc tgaaggcagc    360

agctgggatt gaaaaggggg cccggcaaac agggaaagag gtggcaggcc tggtgacctt    420

gaagcatgtg tatgagattg cccgcatcaa agctcaggat gaggcatttg ccctgcagga    480

tgtacccctg tcgtctgttg tccgctccat catcgggtct gcccgttctc tgggcattcg    540

cgtggtgaag gacctcagtt cagaagagct tgcagctttc cagaaggaac gagccatctt    600

cctggctgct cagaaggagg cagatttggc tgcccaagaa gaagctgcca agaagtgacc    660

cttgccccac caactcccag atttcaaagg aggtagttgc aaaagctgtg cccaagggga    720

ggaaggaggt cacaccaata tgatgatggt tttcatgact ttgaatgata tatttttgta    780

catctagctg tatcgaggca tcaggcctga ataaacatcc tttcttaccc aaaaaaaaaa    840


<210>  2717
<211>  192
<212>  PRT
<213>  Homosapiens

<400>  2717

Met Ser Lys Leu Gly Arg Ala Ala Arg Gly Leu Arg Lys Pro Glu Val 
1               5                   10                  15      


Gly Gly Val Ile Arg Ala Ile Val Arg Ala Gly Leu Ala Met Pro Gly 
            20                  25                  30          


Pro Pro Leu Gly Pro Val Leu Gly Gln Arg Gly Val Ser Ile Asn Gln 
        35                  40                  45              


Phe Cys Lys Glu Phe Asn Glu Arg Thr Lys Asp Ile Lys Glu Gly Ile 
    50                  55                  60                  


Pro Leu Pro Thr Lys Ile Leu Val Lys Pro Asp Arg Thr Phe Glu Ile 
65                  70                  75                  80  


Lys Ile Gly Gln Pro Thr Val Ser Tyr Phe Leu Lys Ala Ala Ala Gly 
                85                  90                  95      


Ile Glu Lys Gly Ala Arg Gln Thr Gly Lys Glu Val Ala Gly Leu Val 
            100                 105                 110         


Thr Leu Lys His Val Tyr Glu Ile Ala Arg Ile Lys Ala Gln Asp Glu 
        115                 120                 125             


Ala Phe Ala Leu Gln Asp Val Pro Leu Ser Ser Val Val Arg Ser Ile 
    130                 135                 140                 


Ile Gly Ser Ala Arg Ser Leu Gly Ile Arg Val Val Lys Asp Leu Ser 
145                 150                 155                 160 


Ser Glu Glu Leu Ala Ala Phe Gln Lys Glu Arg Ala Ile Phe Leu Ala 
                165                 170                 175     


Ala Gln Lys Glu Ala Asp Leu Ala Ala Gln Glu Glu Ala Ala Lys Lys 
            180                 185                 190         


<210>  2718
<211>  762
<212>  DNA
<213>  Homosapiens

<400>  2718
ctctggccca agatggtggc gcccagagct tcgctcttgc tgctcccctg aggtgaactg     60

aagccagcag ccccgcatca tgtcaaagct cggccgggcc gcccggggcc tcaggaagcc    120

cgagagaggc gtttccatca accagttttg caaggagttc aatgagagga caaaggacat    180

caaggaaggc attcctctgc ctaccaagat tttagtgaag cctgacagga catttgaaat    240

taagattgga cagcccactg tttcctactt cctgaaggca gcagctggga ttgaaaaggg    300

ggcccggcaa acagggaaag aggtggcagg cctggtgacc ttgaagcatg tgtatgagat    360

tgcccgcatc aaagctcagg atgaggcatt tgccctgcag gatgtacccc tgtcgtctgt    420

tgtccgctcc atcatcgggt ctgcccgttc tctgggcatt cgcgtggtga aggacctcag    480

ttcagaagag cttgcagctt tccagaagga acgagccatc ttcctggctg ctcagaagga    540

ggcagatttg gctgcccaag aagaagctgc caagaagtga cccttgcccc accaactccc    600

agatttcaaa ggaggtagtt gcaaaagctg tgcccaaggg gaggaaggag gtcacaccaa    660

tatgatgatg gttttcatga ctttgaatga tatatttttg tacatctagc tgtatcgagg    720

catcaggcct gaataaacat cctttcttac ccaaaaaaaa aa                       762


<210>  2719
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  2719

Met Ser Lys Leu Gly Arg Ala Ala Arg Gly Leu Arg Lys Pro Glu Arg 
1               5                   10                  15      


Gly Val Ser Ile Asn Gln Phe Cys Lys Glu Phe Asn Glu Arg Thr Lys 
            20                  25                  30          


Asp Ile Lys Glu Gly Ile Pro Leu Pro Thr Lys Ile Leu Val Lys Pro 
        35                  40                  45              


Asp Arg Thr Phe Glu Ile Lys Ile Gly Gln Pro Thr Val Ser Tyr Phe 
    50                  55                  60                  


Leu Lys Ala Ala Ala Gly Ile Glu Lys Gly Ala Arg Gln Thr Gly Lys 
65                  70                  75                  80  


Glu Val Ala Gly Leu Val Thr Leu Lys His Val Tyr Glu Ile Ala Arg 
                85                  90                  95      


Ile Lys Ala Gln Asp Glu Ala Phe Ala Leu Gln Asp Val Pro Leu Ser 
            100                 105                 110         


Ser Val Val Arg Ser Ile Ile Gly Ser Ala Arg Ser Leu Gly Ile Arg 
        115                 120                 125             


Val Val Lys Asp Leu Ser Ser Glu Glu Leu Ala Ala Phe Gln Lys Glu 
    130                 135                 140                 


Arg Ala Ile Phe Leu Ala Ala Gln Lys Glu Ala Asp Leu Ala Ala Gln 
145                 150                 155                 160 


Glu Glu Ala Ala Lys Lys 
                165     


<210>  2720
<211>  934
<212>  DNA
<213>  Homosapiens

<400>  2720
ctctggccca agatggtggc gcccagagct tcgctcttgc tgctcccctg aggtgaactg     60

aagccagcag ccccgcatca tgtcaaagct cggccgggcc gcccggggcc tcaggaagcc    120

cgaggtcggc ggtgtgatcc gggcgatcgt gcgggcaggc ctggccatgc ccgggccccc    180

actaggccca gtgctgggtc agagaggcgt ttccatcaac cagttttgca aggagttcaa    240

tgagaggaca aaggacatca aggaaggcat tcctctgcct accaagattt tagtgaagcc    300

tgacaggaca tttgaaatta agattggaca gcccactgtt tcctacttcc tgaaggcagc    360

agctgggatt gaaaaggggg cccggcaaac agggaaagag gtggcaggcc tggtgacctt    420

gaagcatgtg tatgagattg cccgcatcaa agctcaggat gaggcatttg ccctgcagga    480

tgtacccctg tcgtctgttg tccgctccat catcgggtct gcccgttctc tgggcattcg    540

cgtggtgaag gaacgttgtt ctgcaaatgt tctaagaaat ggaaagatct ccatgaagga    600

tccaagtggg agaagttcag tgtgacctgg gtctgtcgtc ctagagcctc agttcagaag    660

agcttgcagc tttccagaag gaacgagcca tcttcctggc tgctcagaag gaggcagatt    720

tggctgccca agaagaagct gccaagaagt gacccttgcc ccaccaactc ccagatttca    780

aaggaggtag ttgcaaaagc tgtgcccaag gggaggaagg aggtcacacc aatatgatga    840

tggttttcat gactttgaat gatatatttt tgtacatcta gctgtatcga ggcatcaggc    900

ctgaataaac atcctttctt acccaaaaaa aaaa                                934


<210>  2721
<211>  181
<212>  PRT
<213>  Homosapiens

<400>  2721

Met Ser Lys Leu Gly Arg Ala Ala Arg Gly Leu Arg Lys Pro Glu Val 
1               5                   10                  15      


Gly Gly Val Ile Arg Ala Ile Val Arg Ala Gly Leu Ala Met Pro Gly 
            20                  25                  30          


Pro Pro Leu Gly Pro Val Leu Gly Gln Arg Gly Val Ser Ile Asn Gln 
        35                  40                  45              


Phe Cys Lys Glu Phe Asn Glu Arg Thr Lys Asp Ile Lys Glu Gly Ile 
    50                  55                  60                  


Pro Leu Pro Thr Lys Ile Leu Val Lys Pro Asp Arg Thr Phe Glu Ile 
65                  70                  75                  80  


Lys Ile Gly Gln Pro Thr Val Ser Tyr Phe Leu Lys Ala Ala Ala Gly 
                85                  90                  95      


Ile Glu Lys Gly Ala Arg Gln Thr Gly Lys Glu Val Ala Gly Leu Val 
            100                 105                 110         


Thr Leu Lys His Val Tyr Glu Ile Ala Arg Ile Lys Ala Gln Asp Glu 
        115                 120                 125             


Ala Phe Ala Leu Gln Asp Val Pro Leu Ser Ser Val Val Arg Ser Ile 
    130                 135                 140                 


Ile Gly Ser Ala Arg Ser Leu Gly Ile Arg Val Val Lys Glu Arg Cys 
145                 150                 155                 160 


Ser Ala Asn Val Leu Arg Asn Gly Lys Ile Ser Met Lys Asp Pro Ser 
                165                 170                 175     


Gly Arg Ser Ser Val 
            180     


<210>  2722
<211>  2697
<212>  DNA
<213>  Homosapiens

<400>  2722
gagccgccgc gggccgggcc catcccgccg cagcggcccg gggccgagca ggggctaggc     60

ggggagggag cggcgcccag cggggcccgg agcgtggcca gaatggtgct ggaaggaaac    120

cctgaagtgg ggtccccccg aacctcagac ctccagcacc gggggaacaa gggctcttgc    180

gttctctcct ctcccggtga agatgcgcag ccaggcgagg agcccatcaa gtatggtgaa    240

ctcatcgtcc tgggatgctg tgaggaagga ggtgaggaaa ccgaggctca gagaggggaa    300

gtgactggcc caagggcact cagctgctac aatggttgtc tggcaagtgg ggacaagggc    360

cgccggcgaa gccgcctggc actgagccgc cggtcgcacg ccaacggggt gaagccagac    420

gtcatgctcc acatctccac gccgctcgtc tccaaggcac tgagtaaccg tggtcagcac    480

agcatctcgt atacactgtc ccggagccac tcggtcatag tggagtatac acatgatagc    540

gacacagaca tgttccagat tggccgctcc acagagaaca tgattgactt cgtggtaaca    600

gacacgtccc ctggaggagg ggctgccgag ggcccttctg cccagagcac catctcccgc    660

tatgcctgcc gcatcctctg tgaccgccgg ccaccctata ctgcccgcat ctatgccgct    720

ggcttcgatg cctctagcaa catcttcctt ggagagcgag cggccaaatg gcggacccca    780

gatggcctga tggatggact gaccaccaat ggagtcctgg tgatgcaccc ggcaggcggc    840

ttctccgagg actcagcccc gggtgtctgg cgggagatct cggtctgtgg gaatgtgtac    900

acattgcggg acagccgctc agcccagcag cggggcaagc tggtggaaaa cgagtccaac    960

gtgctgcagg acggctctct catcgacctg tgtggggcca cactgctgtg gcgcacaccg   1020

gcggggctgc tgcgggctcc cacactgaag caactggagg cccagcggca ggaggcaaat   1080

gcagcgcggc cccagtgccc cgtgggcctc agcactctgg ccttccccag cccagcccgt   1140

ggccgcacag cgcccgacaa acagcagccc tgggtctacg tccgctgcgg gcacgtccat   1200

ggctaccacg gctggggctg ccggcgggag cggggccccc aggagcgcga atgtcctctc   1260

tgccgccttg tggggcctta tgtgcctcta tggcttggcc aggaggccgg cctctgcctg   1320

gaccctgggc cgcctagcca tgcctttgca ccttgcggcc acgtctgctc tgagaagact   1380

gcccgctact gggcccagac accactgccc cacggcaccc atgctttcca tgccgcctgc   1440

cccttttgcg gggcctggct taccggcgag catggctgcg tccgcctcat tttccagggc   1500

ccgctggatt aggctccctg gggccccctg ctgctgtgcc cacctgccca cccaggtccc   1560

cacctcctgc agcccagagg gagctctgca tgtgggacac tccctgctgg cacagccaca   1620

ccagatggac atgttggatg ggctgtgccc ttccccccaa ctgtggcccc ccaaggaggt   1680

ccccaagatc tccaccccag tcatgctgat ggggccttca gcaccagctc tgtcctgggt   1740

cgatggagga aagcccagcc ccatggcctt gcccttcctg gggcatccca catcgtgccg   1800

ccgacactgt gtgcccctgg gggagtgaag gggccagggg cctttgaccc ccagcttagg   1860

ctggctatgc cctgagcctg ccaacccagt ttcagacact catccttcat ccttcctgct   1920

gccgccctgg gttcctctat aaacctcgct gctcagctgc ccccacaagt cccacatgcc   1980

ccgcatgcgt gcaatgcctc cagcccccaa gtgagtggtg ggtgggtggc aggctgggcc   2040

tagcacttgc tgatagccac tatgggctcg actctgtgct aagtggtatc tggggacaca   2100

gaggcaatca gacctggttc cccccctggt ggagttcaca gtctagtgga ggacagactg   2160

ttaacaaatg gcaacacggc ttcatgcgtg ccaggatcag agtacaaatc aggttgtggc   2220

aggcctcact ggtaatggaa aagtgaggga ggcttcacgg aggaggtgtc ataggagctc   2280

agcctcaacg gctgctcgga accctccgag tccacaagat gggaagcaag tccacaagat   2340

gggaagcgtg ctctatacag aagggagggc ctgtgcacag gctcaggtgt cagtaagcca   2400

gaaatccagg gacagagtca ggatggctgg agcatggact gcggggggaa cagagaaggg   2460

ggtggagcaa aaggttggga ccatgtgacc agggaagatg ctggatggag gattctgaac   2520

ctcatttgtg gacggtcagg agtcaacaaa gggaggagag aggactcact ggtcaagagt   2580

gtcggctgtg acacaagggc catcatccct gaatgcccac catgtgcccc gcactgtgct   2640

gatgatgata ataataacta cgtccattga gcactctcca aaaaaaaaaa aaaaaaa      2697


<210>  2723
<211>  469
<212>  PRT
<213>  Homosapiens

<400>  2723

Met Val Leu Glu Gly Asn Pro Glu Val Gly Ser Pro Arg Thr Ser Asp 
1               5                   10                  15      


Leu Gln His Arg Gly Asn Lys Gly Ser Cys Val Leu Ser Ser Pro Gly 
            20                  25                  30          


Glu Asp Ala Gln Pro Gly Glu Glu Pro Ile Lys Tyr Gly Glu Leu Ile 
        35                  40                  45              


Val Leu Gly Cys Cys Glu Glu Gly Gly Glu Glu Thr Glu Ala Gln Arg 
    50                  55                  60                  


Gly Glu Val Thr Gly Pro Arg Ala Leu Ser Cys Tyr Asn Gly Cys Leu 
65                  70                  75                  80  


Ala Ser Gly Asp Lys Gly Arg Arg Arg Ser Arg Leu Ala Leu Ser Arg 
                85                  90                  95      


Arg Ser His Ala Asn Gly Val Lys Pro Asp Val Met Leu His Ile Ser 
            100                 105                 110         


Thr Pro Leu Val Ser Lys Ala Leu Ser Asn Arg Gly Gln His Ser Ile 
        115                 120                 125             


Ser Tyr Thr Leu Ser Arg Ser His Ser Val Ile Val Glu Tyr Thr His 
    130                 135                 140                 


Asp Ser Asp Thr Asp Met Phe Gln Ile Gly Arg Ser Thr Glu Asn Met 
145                 150                 155                 160 


Ile Asp Phe Val Val Thr Asp Thr Ser Pro Gly Gly Gly Ala Ala Glu 
                165                 170                 175     


Gly Pro Ser Ala Gln Ser Thr Ile Ser Arg Tyr Ala Cys Arg Ile Leu 
            180                 185                 190         


Cys Asp Arg Arg Pro Pro Tyr Thr Ala Arg Ile Tyr Ala Ala Gly Phe 
        195                 200                 205             


Asp Ala Ser Ser Asn Ile Phe Leu Gly Glu Arg Ala Ala Lys Trp Arg 
    210                 215                 220                 


Thr Pro Asp Gly Leu Met Asp Gly Leu Thr Thr Asn Gly Val Leu Val 
225                 230                 235                 240 


Met His Pro Ala Gly Gly Phe Ser Glu Asp Ser Ala Pro Gly Val Trp 
                245                 250                 255     


Arg Glu Ile Ser Val Cys Gly Asn Val Tyr Thr Leu Arg Asp Ser Arg 
            260                 265                 270         


Ser Ala Gln Gln Arg Gly Lys Leu Val Glu Asn Glu Ser Asn Val Leu 
        275                 280                 285             


Gln Asp Gly Ser Leu Ile Asp Leu Cys Gly Ala Thr Leu Leu Trp Arg 
    290                 295                 300                 


Thr Pro Ala Gly Leu Leu Arg Ala Pro Thr Leu Lys Gln Leu Glu Ala 
305                 310                 315                 320 


Gln Arg Gln Glu Ala Asn Ala Ala Arg Pro Gln Cys Pro Val Gly Leu 
                325                 330                 335     


Ser Thr Leu Ala Phe Pro Ser Pro Ala Arg Gly Arg Thr Ala Pro Asp 
            340                 345                 350         


Lys Gln Gln Pro Trp Val Tyr Val Arg Cys Gly His Val His Gly Tyr 
        355                 360                 365             


His Gly Trp Gly Cys Arg Arg Glu Arg Gly Pro Gln Glu Arg Glu Cys 
    370                 375                 380                 


Pro Leu Cys Arg Leu Val Gly Pro Tyr Val Pro Leu Trp Leu Gly Gln 
385                 390                 395                 400 


Glu Ala Gly Leu Cys Leu Asp Pro Gly Pro Pro Ser His Ala Phe Ala 
                405                 410                 415     


Pro Cys Gly His Val Cys Ser Glu Lys Thr Ala Arg Tyr Trp Ala Gln 
            420                 425                 430         


Thr Pro Leu Pro His Gly Thr His Ala Phe His Ala Ala Cys Pro Phe 
        435                 440                 445             


Cys Gly Ala Trp Leu Thr Gly Glu His Gly Cys Val Arg Leu Ile Phe 
    450                 455                 460                 


Gln Gly Pro Leu Asp 
465                 


<210>  2724
<211>  2694
<212>  DNA
<213>  Homosapiens

<400>  2724
aatgaatggg ggagccggaa gcaggaagtg agtttgcgaa cggagcagct gctgcagggc     60

ccatggcgga cacccagtac atcctgccca atgacatcgg cgtgtctagc ctggactgcc    120

gtgaggcctt ccgcctgctg tcacccacag agcgcctcta tgcctaccac ctgtcccgtg    180

ccgcctggta cggaggcctg gctgtgctgc ttcagacctc ccctgaggcc ccctacatct    240

atgctctgct cagccgcctc ttccgcgccc aggaccccga ccagctgcgc caacatgccc    300

tggctgaagg ccttaccgag gaggagtatc aggcgttcct ggtctatgcc gcgggtgttt    360

actccaacat gggcaactac aagtcctttg gtgacaccaa gtttgttccc aacttgccca    420

aggaaaagct ggaacgggtg atcctaggga gtgaggctgc tcagcagcac ccagaagaag    480

tcaggggcct ctggcagacc tgcggggagc ttatgttctc tctggagcca aggcttcgac    540

acctcggact ggggaaggag ggaatcacca cctatttctc tgggaattgt accatggaag    600

atgccaaatt ggcccaggac tttctggact cacagaacct cagtgcctac aacacccggc    660

tcttcaaaga ggtcgatgga gaagggaagc cctactacga ggtgcggctg gcttctgtgc    720

ttggctcaga gccttccctg gactctgagg tgacttccaa gctgaagagc tatgaattcc    780

ggggaagccc tttccaggtg acccgggggg actacgcgcc catcctccag aaggtggtgg    840

agcagctgga gaaagccaag gcctatgcag ccaacagcca ccaggggcag atgctggccc    900

agtatataga gagcttcacc cagggctcca tcgaggccca caagaggggc tcccgcttct    960

ggatccagga caaaggcccc atcgtggaga gttacatcgg gttcatcgag agctaccgcg   1020

acccctttgg ttcccgagga gaatttgaag gtttcgtagc tgtggtgaac aaggccatga   1080

gtgccaagtt tgagcggctg gtggcgagcg cagagcagct gctgaaggag ctgccctggc   1140

ccccaacctt tgagaaggac aagttcctca cccctgactt cacctccctg gatgttctca   1200

ccttcgctgg ctccggcatc cctgccggca tcaacatccc caactacgat gatctgaggc   1260

agacggaagg ctttaagaac gtgtcgctgg ggaatgtgct ggctgtggcc tacgccacgc   1320

agcgggagaa gcttaccttt ctggaggagg atgacaagga cctgtacatc ctctggaagg   1380

ggccctcctt cgatgtgcag gtgggcctgc acgagctgct gggccatggc agtggcaagc   1440

tcttcgtaca ggacgaaaaa ggagcattca actttgacca ggaaacagtg atcaacccag   1500

agacgggcga gcagattcag agctggtatc ggagcgggga gacctgggat agcaagttca   1560

gcaccatcgc ctccagctac gaagagtgcc gggctgagag cgtgggtctc tacctctgtc   1620

tccacccgca agtgctggag atctttggct ttgagggggc tgatgcggag gacgtgatct   1680

acgtgaactg gctcaacatg gttcgggccg ggctgctcgc tctggagttc tacacacctg   1740

aggccttcaa ctggcgacag gcccatatgc aggcccggtt tgtgatcctg agagtcttgc   1800

tggaggctgg cgagggactc gttaccatca ctcccaccac aggctccgat gggcgcccag   1860

atgcccgggt ccgcctcgac cgcagcaaga tccggtctgt gggcaagcct gctctagagc   1920

gcttcctgcg gagacttcag gtgctgaagt ccacagggga tgtggccgga gggcgggccc   1980

tgtacgaggg gtatgcaaca gtcactgatg cgccccccga gtgcttcctc accctcaggg   2040

acacggtgct gctgcgtaag gaatctcgga agctcattgt tcagcccaac actcgccttg   2100

aaggctcaga cgtgcagctt ctggaatacg aggcgtcagc tgctggcctc atccgatcct   2160

tctctgagcg tttcccagag gatggacccg agttggagga gatcctcaca cagctggcca   2220

cagccgatgc ccgattctgg aagggcccca gtgaggcccc atctggccaa gcttgaggaa   2280

gatgtgtggc cttgccccca attccatcag accaaggctg caagtggccc tccattcgtg   2340

tgtgtattta ggggctgggg agggggaggg gcaggagctt ggaccttggt actacctcag   2400

ctgagggtgg tgacacaacc ccttccattt gtcagcactt tccagcctgc caattgcttc   2460

ccctctgtga tctcatttca tctgcactgc catacgtgga gtgagcaaga cagggcttac   2520

catcctgtct accagatgag gaaatggcag ttctgagaag tcactggtct agatcccgca   2580

ggtggcacgt gacagctagg gttcaaaacg ttctcaccaa atccaatgct cctcacatat   2640

taattttata accagacaaa taaatattag agacaaccac catcaaaaaa aaaa         2694


<210>  2725
<211>  737
<212>  PRT
<213>  Homosapiens

<400>  2725

Met Ala Asp Thr Gln Tyr Ile Leu Pro Asn Asp Ile Gly Val Ser Ser 
1               5                   10                  15      


Leu Asp Cys Arg Glu Ala Phe Arg Leu Leu Ser Pro Thr Glu Arg Leu 
            20                  25                  30          


Tyr Ala Tyr His Leu Ser Arg Ala Ala Trp Tyr Gly Gly Leu Ala Val 
        35                  40                  45              


Leu Leu Gln Thr Ser Pro Glu Ala Pro Tyr Ile Tyr Ala Leu Leu Ser 
    50                  55                  60                  


Arg Leu Phe Arg Ala Gln Asp Pro Asp Gln Leu Arg Gln His Ala Leu 
65                  70                  75                  80  


Ala Glu Gly Leu Thr Glu Glu Glu Tyr Gln Ala Phe Leu Val Tyr Ala 
                85                  90                  95      


Ala Gly Val Tyr Ser Asn Met Gly Asn Tyr Lys Ser Phe Gly Asp Thr 
            100                 105                 110         


Lys Phe Val Pro Asn Leu Pro Lys Glu Lys Leu Glu Arg Val Ile Leu 
        115                 120                 125             


Gly Ser Glu Ala Ala Gln Gln His Pro Glu Glu Val Arg Gly Leu Trp 
    130                 135                 140                 


Gln Thr Cys Gly Glu Leu Met Phe Ser Leu Glu Pro Arg Leu Arg His 
145                 150                 155                 160 


Leu Gly Leu Gly Lys Glu Gly Ile Thr Thr Tyr Phe Ser Gly Asn Cys 
                165                 170                 175     


Thr Met Glu Asp Ala Lys Leu Ala Gln Asp Phe Leu Asp Ser Gln Asn 
            180                 185                 190         


Leu Ser Ala Tyr Asn Thr Arg Leu Phe Lys Glu Val Asp Gly Glu Gly 
        195                 200                 205             


Lys Pro Tyr Tyr Glu Val Arg Leu Ala Ser Val Leu Gly Ser Glu Pro 
    210                 215                 220                 


Ser Leu Asp Ser Glu Val Thr Ser Lys Leu Lys Ser Tyr Glu Phe Arg 
225                 230                 235                 240 


Gly Ser Pro Phe Gln Val Thr Arg Gly Asp Tyr Ala Pro Ile Leu Gln 
                245                 250                 255     


Lys Val Val Glu Gln Leu Glu Lys Ala Lys Ala Tyr Ala Ala Asn Ser 
            260                 265                 270         


His Gln Gly Gln Met Leu Ala Gln Tyr Ile Glu Ser Phe Thr Gln Gly 
        275                 280                 285             


Ser Ile Glu Ala His Lys Arg Gly Ser Arg Phe Trp Ile Gln Asp Lys 
    290                 295                 300                 


Gly Pro Ile Val Glu Ser Tyr Ile Gly Phe Ile Glu Ser Tyr Arg Asp 
305                 310                 315                 320 


Pro Phe Gly Ser Arg Gly Glu Phe Glu Gly Phe Val Ala Val Val Asn 
                325                 330                 335     


Lys Ala Met Ser Ala Lys Phe Glu Arg Leu Val Ala Ser Ala Glu Gln 
            340                 345                 350         


Leu Leu Lys Glu Leu Pro Trp Pro Pro Thr Phe Glu Lys Asp Lys Phe 
        355                 360                 365             


Leu Thr Pro Asp Phe Thr Ser Leu Asp Val Leu Thr Phe Ala Gly Ser 
    370                 375                 380                 


Gly Ile Pro Ala Gly Ile Asn Ile Pro Asn Tyr Asp Asp Leu Arg Gln 
385                 390                 395                 400 


Thr Glu Gly Phe Lys Asn Val Ser Leu Gly Asn Val Leu Ala Val Ala 
                405                 410                 415     


Tyr Ala Thr Gln Arg Glu Lys Leu Thr Phe Leu Glu Glu Asp Asp Lys 
            420                 425                 430         


Asp Leu Tyr Ile Leu Trp Lys Gly Pro Ser Phe Asp Val Gln Val Gly 
        435                 440                 445             


Leu His Glu Leu Leu Gly His Gly Ser Gly Lys Leu Phe Val Gln Asp 
    450                 455                 460                 


Glu Lys Gly Ala Phe Asn Phe Asp Gln Glu Thr Val Ile Asn Pro Glu 
465                 470                 475                 480 


Thr Gly Glu Gln Ile Gln Ser Trp Tyr Arg Ser Gly Glu Thr Trp Asp 
                485                 490                 495     


Ser Lys Phe Ser Thr Ile Ala Ser Ser Tyr Glu Glu Cys Arg Ala Glu 
            500                 505                 510         


Ser Val Gly Leu Tyr Leu Cys Leu His Pro Gln Val Leu Glu Ile Phe 
        515                 520                 525             


Gly Phe Glu Gly Ala Asp Ala Glu Asp Val Ile Tyr Val Asn Trp Leu 
    530                 535                 540                 


Asn Met Val Arg Ala Gly Leu Leu Ala Leu Glu Phe Tyr Thr Pro Glu 
545                 550                 555                 560 


Ala Phe Asn Trp Arg Gln Ala His Met Gln Ala Arg Phe Val Ile Leu 
                565                 570                 575     


Arg Val Leu Leu Glu Ala Gly Glu Gly Leu Val Thr Ile Thr Pro Thr 
            580                 585                 590         


Thr Gly Ser Asp Gly Arg Pro Asp Ala Arg Val Arg Leu Asp Arg Ser 
        595                 600                 605             


Lys Ile Arg Ser Val Gly Lys Pro Ala Leu Glu Arg Phe Leu Arg Arg 
    610                 615                 620                 


Leu Gln Val Leu Lys Ser Thr Gly Asp Val Ala Gly Gly Arg Ala Leu 
625                 630                 635                 640 


Tyr Glu Gly Tyr Ala Thr Val Thr Asp Ala Pro Pro Glu Cys Phe Leu 
                645                 650                 655     


Thr Leu Arg Asp Thr Val Leu Leu Arg Lys Glu Ser Arg Lys Leu Ile 
            660                 665                 670         


Val Gln Pro Asn Thr Arg Leu Glu Gly Ser Asp Val Gln Leu Leu Glu 
        675                 680                 685             


Tyr Glu Ala Ser Ala Ala Gly Leu Ile Arg Ser Phe Ser Glu Arg Phe 
    690                 695                 700                 


Pro Glu Asp Gly Pro Glu Leu Glu Glu Ile Leu Thr Gln Leu Ala Thr 
705                 710                 715                 720 


Ala Asp Ala Arg Phe Trp Lys Gly Pro Ser Glu Ala Pro Ser Gly Gln 
                725                 730                 735     


Ala 
    


<210>  2726
<211>  2697
<212>  DNA
<213>  Homosapiens

<400>  2726
aatgaatggg ggagccggaa gcaggaagtg agtttgcgaa cggagcagct gctgcagcag     60

ggcccatggc ggacacccag tacatcctgc ccaatgacat cggcgtgtct agcctggact    120

gccgtgaggc cttccgcctg ctgtcaccca cagagcgcct ctatgcctac cacctgtccc    180

gtgccgcctg gtacggaggc ctggctgtgc tgcttcagac ctcccctgag gccccctaca    240

tctatgctct gctcagccgc ctcttccgcg cccaggaccc cgaccagctg cgccaacatg    300

ccctggctga aggccttacc gaggaggagt atcaggcgtt cctggtctat gccgcgggtg    360

tttactccaa catgggcaac tacaagtcct ttggtgacac caagtttgtt cccaacttgc    420

ccaaggaaaa gctggaacgg gtgatcctag ggagtgaggc tgctcagcag cacccagaag    480

aagtcagggg cctctggcag acctgcgggg agcttatgtt ctctctggag ccaaggcttc    540

gacacctcgg actggggaag gagggaatca ccacctattt ctctgggaat tgtaccatgg    600

aagatgccaa attggcccag gactttctgg actcacagaa cctcagtgcc tacaacaccc    660

ggctcttcaa agaggtcgat ggagaaggga agccctacta cgaggtgcgg ctggcttctg    720

tgcttggctc agagccttcc ctggactctg aggtgacttc caagctgaag agctatgaat    780

tccggggaag ccctttccag gtgacccggg gggactacgc gcccatcctc cagaaggtgg    840

tggagcagct ggagaaagcc aaggcctatg cagccaacag ccaccagggg cagatgctgg    900

cccagtatat agagagcttc acccagggct ccatcgaggc ccacaagagg ggctcccgct    960

tctggatcca ggacaaaggc cccatcgtgg agagttacat cgggttcatc gagagctacc   1020

gcgacccctt tggttcccga ggagaatttg aaggtttcgt agctgtggtg aacaaggcca   1080

tgagtgccaa gtttgagcgg ctggtggcga gcgcagagca gctgctgaag gagctgccct   1140

ggcccccaac ctttgagaag gacaagttcc tcacccctga cttcacctcc ctggatgttc   1200

tcaccttcgc tggctccggc atccctgccg gcatcaacat ccccaactac gatgatctga   1260

ggcagacgga aggctttaag aacgtgtcgc tggggaatgt gctggctgtg gcctacgcca   1320

cgcagcggga gaagcttacc tttctggagg aggatgacaa ggacctgtac atcctctgga   1380

aggggccctc cttcgatgtg caggtgggcc tgcacgagct gctgggccat ggcagtggca   1440

agctcttcgt acaggacgaa aaaggagcat tcaactttga ccaggaaaca gtgatcaacc   1500

cagagacggg cgagcagatt cagagctggt atcggagcgg ggagacctgg gatagcaagt   1560

tcagcaccat cgcctccagc tacgaagagt gccgggctga gagcgtgggt ctctacctct   1620

gtctccaccc gcaagtgctg gagatctttg gctttgaggg ggctgatgcg gaggacgtga   1680

tctacgtgaa ctggctcaac atggttcggg ccgggctgct cgctctggag ttctacacac   1740

ctgaggcctt caactggcga caggcccata tgcaggcccg gtttgtgatc ctgagagtct   1800

tgctggaggc tggcgaggga ctcgttacca tcactcccac cacaggctcc gatgggcgcc   1860

cagatgcccg ggtccgcctc gaccgcagca agatccggtc tgtgggcaag cctgctctag   1920

agcgcttcct gcggagactt caggtgctga agtccacagg ggatgtggcc ggagggcggg   1980

ccctgtacga ggggtatgca acagtcactg atgcgccccc cgagtgcttc ctcaccctca   2040

gggacacggt gctgctgcgt aaggaatctc ggaagctcat tgttcagccc aacactcgcc   2100

ttgaaggctc agacgtgcag cttctggaat acgaggcgtc agctgctggc ctcatccgat   2160

ccttctctga gcgtttccca gaggatggac ccgagttgga ggagatcctc acacagctgg   2220

ccacagccga tgcccgattc tggaagggcc ccagtgaggc cccatctggc caagcttgag   2280

gaagatgtgt ggccttgccc ccaattccat cagaccaagg ctgcaagtgg ccctccattc   2340

gtgtgtgtat ttaggggctg gggaggggga ggggcaggag cttggacctt ggtactacct   2400

cagctgaggg tggtgacaca accccttcca tttgtcagca ctttccagcc tgccaattgc   2460

ttcccctctg tgatctcatt tcatctgcac tgccatacgt ggagtgagca agacagggct   2520

taccatcctg tctaccagat gaggaaatgg cagttctgag aagtcactgg tctagatccc   2580

gcaggtggca cgtgacagct agggttcaaa acgttctcac caaatccaat gctcctcaca   2640

tattaatttt ataaccagac aaataaatat tagagacaac caccatcaaa aaaaaaa      2697


<210>  2727
<211>  737
<212>  PRT
<213>  Homosapiens

<400>  2727

Met Ala Asp Thr Gln Tyr Ile Leu Pro Asn Asp Ile Gly Val Ser Ser 
1               5                   10                  15      


Leu Asp Cys Arg Glu Ala Phe Arg Leu Leu Ser Pro Thr Glu Arg Leu 
            20                  25                  30          


Tyr Ala Tyr His Leu Ser Arg Ala Ala Trp Tyr Gly Gly Leu Ala Val 
        35                  40                  45              


Leu Leu Gln Thr Ser Pro Glu Ala Pro Tyr Ile Tyr Ala Leu Leu Ser 
    50                  55                  60                  


Arg Leu Phe Arg Ala Gln Asp Pro Asp Gln Leu Arg Gln His Ala Leu 
65                  70                  75                  80  


Ala Glu Gly Leu Thr Glu Glu Glu Tyr Gln Ala Phe Leu Val Tyr Ala 
                85                  90                  95      


Ala Gly Val Tyr Ser Asn Met Gly Asn Tyr Lys Ser Phe Gly Asp Thr 
            100                 105                 110         


Lys Phe Val Pro Asn Leu Pro Lys Glu Lys Leu Glu Arg Val Ile Leu 
        115                 120                 125             


Gly Ser Glu Ala Ala Gln Gln His Pro Glu Glu Val Arg Gly Leu Trp 
    130                 135                 140                 


Gln Thr Cys Gly Glu Leu Met Phe Ser Leu Glu Pro Arg Leu Arg His 
145                 150                 155                 160 


Leu Gly Leu Gly Lys Glu Gly Ile Thr Thr Tyr Phe Ser Gly Asn Cys 
                165                 170                 175     


Thr Met Glu Asp Ala Lys Leu Ala Gln Asp Phe Leu Asp Ser Gln Asn 
            180                 185                 190         


Leu Ser Ala Tyr Asn Thr Arg Leu Phe Lys Glu Val Asp Gly Glu Gly 
        195                 200                 205             


Lys Pro Tyr Tyr Glu Val Arg Leu Ala Ser Val Leu Gly Ser Glu Pro 
    210                 215                 220                 


Ser Leu Asp Ser Glu Val Thr Ser Lys Leu Lys Ser Tyr Glu Phe Arg 
225                 230                 235                 240 


Gly Ser Pro Phe Gln Val Thr Arg Gly Asp Tyr Ala Pro Ile Leu Gln 
                245                 250                 255     


Lys Val Val Glu Gln Leu Glu Lys Ala Lys Ala Tyr Ala Ala Asn Ser 
            260                 265                 270         


His Gln Gly Gln Met Leu Ala Gln Tyr Ile Glu Ser Phe Thr Gln Gly 
        275                 280                 285             


Ser Ile Glu Ala His Lys Arg Gly Ser Arg Phe Trp Ile Gln Asp Lys 
    290                 295                 300                 


Gly Pro Ile Val Glu Ser Tyr Ile Gly Phe Ile Glu Ser Tyr Arg Asp 
305                 310                 315                 320 


Pro Phe Gly Ser Arg Gly Glu Phe Glu Gly Phe Val Ala Val Val Asn 
                325                 330                 335     


Lys Ala Met Ser Ala Lys Phe Glu Arg Leu Val Ala Ser Ala Glu Gln 
            340                 345                 350         


Leu Leu Lys Glu Leu Pro Trp Pro Pro Thr Phe Glu Lys Asp Lys Phe 
        355                 360                 365             


Leu Thr Pro Asp Phe Thr Ser Leu Asp Val Leu Thr Phe Ala Gly Ser 
    370                 375                 380                 


Gly Ile Pro Ala Gly Ile Asn Ile Pro Asn Tyr Asp Asp Leu Arg Gln 
385                 390                 395                 400 


Thr Glu Gly Phe Lys Asn Val Ser Leu Gly Asn Val Leu Ala Val Ala 
                405                 410                 415     


Tyr Ala Thr Gln Arg Glu Lys Leu Thr Phe Leu Glu Glu Asp Asp Lys 
            420                 425                 430         


Asp Leu Tyr Ile Leu Trp Lys Gly Pro Ser Phe Asp Val Gln Val Gly 
        435                 440                 445             


Leu His Glu Leu Leu Gly His Gly Ser Gly Lys Leu Phe Val Gln Asp 
    450                 455                 460                 


Glu Lys Gly Ala Phe Asn Phe Asp Gln Glu Thr Val Ile Asn Pro Glu 
465                 470                 475                 480 


Thr Gly Glu Gln Ile Gln Ser Trp Tyr Arg Ser Gly Glu Thr Trp Asp 
                485                 490                 495     


Ser Lys Phe Ser Thr Ile Ala Ser Ser Tyr Glu Glu Cys Arg Ala Glu 
            500                 505                 510         


Ser Val Gly Leu Tyr Leu Cys Leu His Pro Gln Val Leu Glu Ile Phe 
        515                 520                 525             


Gly Phe Glu Gly Ala Asp Ala Glu Asp Val Ile Tyr Val Asn Trp Leu 
    530                 535                 540                 


Asn Met Val Arg Ala Gly Leu Leu Ala Leu Glu Phe Tyr Thr Pro Glu 
545                 550                 555                 560 


Ala Phe Asn Trp Arg Gln Ala His Met Gln Ala Arg Phe Val Ile Leu 
                565                 570                 575     


Arg Val Leu Leu Glu Ala Gly Glu Gly Leu Val Thr Ile Thr Pro Thr 
            580                 585                 590         


Thr Gly Ser Asp Gly Arg Pro Asp Ala Arg Val Arg Leu Asp Arg Ser 
        595                 600                 605             


Lys Ile Arg Ser Val Gly Lys Pro Ala Leu Glu Arg Phe Leu Arg Arg 
    610                 615                 620                 


Leu Gln Val Leu Lys Ser Thr Gly Asp Val Ala Gly Gly Arg Ala Leu 
625                 630                 635                 640 


Tyr Glu Gly Tyr Ala Thr Val Thr Asp Ala Pro Pro Glu Cys Phe Leu 
                645                 650                 655     


Thr Leu Arg Asp Thr Val Leu Leu Arg Lys Glu Ser Arg Lys Leu Ile 
            660                 665                 670         


Val Gln Pro Asn Thr Arg Leu Glu Gly Ser Asp Val Gln Leu Leu Glu 
        675                 680                 685             


Tyr Glu Ala Ser Ala Ala Gly Leu Ile Arg Ser Phe Ser Glu Arg Phe 
    690                 695                 700                 


Pro Glu Asp Gly Pro Glu Leu Glu Glu Ile Leu Thr Gln Leu Ala Thr 
705                 710                 715                 720 


Ala Asp Ala Arg Phe Trp Lys Gly Pro Ser Glu Ala Pro Ser Gly Gln 
                725                 730                 735     


Ala 
    


<210>  2728
<211>  3370
<212>  DNA
<213>  Homosapiens

<400>  2728
acgcctgcga agatggccgc tgcgtcctca tcggattccg acgcctgcgg agctgagagc     60

aatgaggcca attcgaagtg gttggatgcg cactacgacc caatggccaa tatccacacc    120

ttttctgcct gcctagcgct ggcagattta catggggatg gggaatacaa gctggtggta    180

ggggaccttg gccctggtgg gcagcagccc cgcctgaagg tgctcaaagg accactggtg    240

atgaccgaaa gcccgctacc tgctctgcca gctgctgctg ccaccttcct catggagcaa    300

catgagcccc ggaccccagc tctggcactt gcttcaggcc cttgtgtcta tgtgtataag    360

aatctcagac cctacttcaa gttcagcctg ccccaattgc ctccaaatcc tctggaacaa    420

gacctttgga accaggccaa agaggaccga atcgacccct taaccctgaa ggagatgctg    480

gagagcatcc gggagacggc agaggagcct ttgtccatcc agtcactcag gtttctgcag    540

ctggagctaa gtgaaatgga ggcatttgta aaccaacaca agtccaactc catcaagcgg    600

cagacagtca tcaccaccat gaccaccttg aagaagaacc tggctgacga ggatgctgtg    660

tcttgcctgg tgctgggcac cgagaacaag gagctcctgg tgcttgaccc cgaggccttc    720

accattttag ccaagatgag ccttcccagc gtccccgtct tcctagaggt ttctggccag    780

tttgatgttg agttccggct tgccgcggcc tgccgcaatg gaaacatcta tattctgaga    840

agagactcca agcaccccaa gtactgcatc gagctgagcg cccagcctgt gggacttatc    900

cgggtacaca aggtcctagt ggtgggcagc acccaagaca gcctgcatgg cttcacccac    960

aaggggaaga agctgtggac agtgcagatg cccgcagcca tcctgaccat gaacctcctg   1020

gagcagcatt cccggggcct gcaggccgtc atggctgggc tggccaatgg agaggtccgc   1080

atttatcgtg acaaggccct gctcaatgtc atccacaccc cggatgcagt gaccagcctt   1140

tgctttggcc ggtacgggcg ggaggacaac accctcatca tgaccactcg aggtggtggc   1200

ctgatcatca agatcctgaa gcgtacagca gtgtttgtag agggaggaag tgaggtgggt   1260

cccccaccag cccaggccat gaaactcaat gtgccccgaa agacccggct ttacgtggat   1320

cagacactgc gagagcggga ggctggcacc gccatgcacc gggccttcca gacagaccta   1380

tacctgctgc gcctacgtgc tgcccgcgcc tacctgcagg ccctcgagtc cagcctgagc   1440

cccctgtcca cgacagcccg agagccactc aagctgcacg ccgtggttca gggccttggc   1500

cccaccttta agctcacact tcacctgcag aacacctcaa caacccgtcc tgtcctgggg   1560

ctgctggtct gcttcctgta caacgaggcg ctctattccc tgccccgggc cttcttcaag   1620

gtacccttgc tggtgccagg gctcaactac cccctggaga cctttgtgga gagtctcagt   1680

aacaagggca tctcagacat catcaaggtg ctggtgcttc gagaaggcca aagtgcaccc   1740

ctgctgagtg cccacgtcaa catgcctggg agcgaggggc tggcggccgc ctgagacctg   1800

agctgctgtg aaagcccctg cacaatcagc cagggagaac tgggcgggtt tagtggcccc   1860

aggcccactc ctcatgcagc agtgtgctgg ggcgacagct cgtctcccct ctcttaagca   1920

cccgcttcct caccaccccc actgttgggc ctatagtagc aggttagtga gtacctaggg   1980

cggctcaact cctcccacag caccaaccca gcatggtccc actgaagtcc tactacgccc   2040

tcccctcccc agccttttcc agaaaccata ctgggctcag atcagagctc cgaagcggtc   2100

aaagtgagct gagcaggaca ggcccagcct ttctccactg ccacgtccct catgcacatc   2160

actcatctcc tgctgcaggc caaggccaaa attgggctag tcctggccag ggaaatcaga   2220

agctcttctt gggtgagatt gagcctcctg ttgctccctg gagttccgga ggctgggctg   2280

cagcccactc agcttgcggg caaaatacgt gctctcctct ctccttgtca gctgagcaaa   2340

cccagggaat agccctcctc tccccaggaa acttctctga aatcttagac ttagccagtc   2400

ttaggcctac gatgccacac aaaggttgtt cagggagaag ggggtgcagg aggcagaggg   2460

tgccccgcag ggagctggtg gctccagccc cactagagct cctaaagatc acacagcagc   2520

tgctcctgac agggatgctc atgcccagaa agcaagccca ggagaggaag gcagagtgtg   2580

acagagcaga gccagggcca ggcgcaccag gagaggcgtt tctggggctc cagagaagtg   2640

ccacgggagg cagaagtcca gaactgccca tatagatgcc cttctacatc ctggagccca   2700

aatcagtcat gtgggtggga agttcccagg gcagtggtca catcgtgaga attagcagga   2760

aaggcggggc ctttcttgtc atagctattt ctgaggatga aatgggagac atatgcccag   2820

cacctgatgt aagtttatat aatgtaatat tatgtaccta ccactaagaa atacatgaac   2880

cgtgccatga ggacagtaag tgttcataaa gcaacatgaa gcaagaaaca gtgcagggtg   2940

cccagtgcac acactagaga gaaattgtga acattaagga caaggagaat tggtgtcttt   3000

ctaaaacata cttatttaaa aacacatacc cacttactaa tgtggaatta cacagtttgt   3060

aacaagaaaa cagtctctcc cattctctag tactgctccc ctacccagca gtcacttcca   3120

gttcattcag ctatttttaa aatgtgctta tatgactctt gcttgatata tcaatcttag   3180

acattacctg ttgactccct gttgtcatac atgaggcttt agctctcttt tgtcagcaac   3240

cctcccccat ccctagttat taggttaaaa aatactcaga ttactatttc tattactatg   3300

tgaaagttaa ctgcggagcc aagagttgga ctataattaa attaccttcc ttgtactttc   3360

tttttaatgg                                                          3370


<210>  2729
<211>  593
<212>  PRT
<213>  Homosapiens

<400>  2729

Met Ala Ala Ala Ser Ser Ser Asp Ser Asp Ala Cys Gly Ala Glu Ser 
1               5                   10                  15      


Asn Glu Ala Asn Ser Lys Trp Leu Asp Ala His Tyr Asp Pro Met Ala 
            20                  25                  30          


Asn Ile His Thr Phe Ser Ala Cys Leu Ala Leu Ala Asp Leu His Gly 
        35                  40                  45              


Asp Gly Glu Tyr Lys Leu Val Val Gly Asp Leu Gly Pro Gly Gly Gln 
    50                  55                  60                  


Gln Pro Arg Leu Lys Val Leu Lys Gly Pro Leu Val Met Thr Glu Ser 
65                  70                  75                  80  


Pro Leu Pro Ala Leu Pro Ala Ala Ala Ala Thr Phe Leu Met Glu Gln 
                85                  90                  95      


His Glu Pro Arg Thr Pro Ala Leu Ala Leu Ala Ser Gly Pro Cys Val 
            100                 105                 110         


Tyr Val Tyr Lys Asn Leu Arg Pro Tyr Phe Lys Phe Ser Leu Pro Gln 
        115                 120                 125             


Leu Pro Pro Asn Pro Leu Glu Gln Asp Leu Trp Asn Gln Ala Lys Glu 
    130                 135                 140                 


Asp Arg Ile Asp Pro Leu Thr Leu Lys Glu Met Leu Glu Ser Ile Arg 
145                 150                 155                 160 


Glu Thr Ala Glu Glu Pro Leu Ser Ile Gln Ser Leu Arg Phe Leu Gln 
                165                 170                 175     


Leu Glu Leu Ser Glu Met Glu Ala Phe Val Asn Gln His Lys Ser Asn 
            180                 185                 190         


Ser Ile Lys Arg Gln Thr Val Ile Thr Thr Met Thr Thr Leu Lys Lys 
        195                 200                 205             


Asn Leu Ala Asp Glu Asp Ala Val Ser Cys Leu Val Leu Gly Thr Glu 
    210                 215                 220                 


Asn Lys Glu Leu Leu Val Leu Asp Pro Glu Ala Phe Thr Ile Leu Ala 
225                 230                 235                 240 


Lys Met Ser Leu Pro Ser Val Pro Val Phe Leu Glu Val Ser Gly Gln 
                245                 250                 255     


Phe Asp Val Glu Phe Arg Leu Ala Ala Ala Cys Arg Asn Gly Asn Ile 
            260                 265                 270         


Tyr Ile Leu Arg Arg Asp Ser Lys His Pro Lys Tyr Cys Ile Glu Leu 
        275                 280                 285             


Ser Ala Gln Pro Val Gly Leu Ile Arg Val His Lys Val Leu Val Val 
    290                 295                 300                 


Gly Ser Thr Gln Asp Ser Leu His Gly Phe Thr His Lys Gly Lys Lys 
305                 310                 315                 320 


Leu Trp Thr Val Gln Met Pro Ala Ala Ile Leu Thr Met Asn Leu Leu 
                325                 330                 335     


Glu Gln His Ser Arg Gly Leu Gln Ala Val Met Ala Gly Leu Ala Asn 
            340                 345                 350         


Gly Glu Val Arg Ile Tyr Arg Asp Lys Ala Leu Leu Asn Val Ile His 
        355                 360                 365             


Thr Pro Asp Ala Val Thr Ser Leu Cys Phe Gly Arg Tyr Gly Arg Glu 
    370                 375                 380                 


Asp Asn Thr Leu Ile Met Thr Thr Arg Gly Gly Gly Leu Ile Ile Lys 
385                 390                 395                 400 


Ile Leu Lys Arg Thr Ala Val Phe Val Glu Gly Gly Ser Glu Val Gly 
                405                 410                 415     


Pro Pro Pro Ala Gln Ala Met Lys Leu Asn Val Pro Arg Lys Thr Arg 
            420                 425                 430         


Leu Tyr Val Asp Gln Thr Leu Arg Glu Arg Glu Ala Gly Thr Ala Met 
        435                 440                 445             


His Arg Ala Phe Gln Thr Asp Leu Tyr Leu Leu Arg Leu Arg Ala Ala 
    450                 455                 460                 


Arg Ala Tyr Leu Gln Ala Leu Glu Ser Ser Leu Ser Pro Leu Ser Thr 
465                 470                 475                 480 


Thr Ala Arg Glu Pro Leu Lys Leu His Ala Val Val Gln Gly Leu Gly 
                485                 490                 495     


Pro Thr Phe Lys Leu Thr Leu His Leu Gln Asn Thr Ser Thr Thr Arg 
            500                 505                 510         


Pro Val Leu Gly Leu Leu Val Cys Phe Leu Tyr Asn Glu Ala Leu Tyr 
        515                 520                 525             


Ser Leu Pro Arg Ala Phe Phe Lys Val Pro Leu Leu Val Pro Gly Leu 
    530                 535                 540                 


Asn Tyr Pro Leu Glu Thr Phe Val Glu Ser Leu Ser Asn Lys Gly Ile 
545                 550                 555                 560 


Ser Asp Ile Ile Lys Val Leu Val Leu Arg Glu Gly Gln Ser Ala Pro 
                565                 570                 575     


Leu Leu Ser Ala His Val Asn Met Pro Gly Ser Glu Gly Leu Ala Ala 
            580                 585                 590         


Ala 
    


<210>  2730
<211>  1319
<212>  DNA
<213>  Homosapiens

<400>  2730
gattccgagc gcctccactg ctggtccgtt ggccagatca actcgccgcg tgggccggcc     60

gttccctgag agtctgagcg ctcgccgcac ccccttccga gcttctattg gccgtagcag    120

acgtccgtct gccgctatct ccgccccaat acggaagcgg cctagtcctc cggctccgac    180

agctgggtgt ccaggccatg gggcagccct gggcggctgg gagcacggac ggggcgcccg    240

cgcagctgcc tctcgtgctc accgcgctgt gggccgcggc cgtgggcctg gagctggctt    300

acgtgctggt gctcggtccc gggccgccgc cgctgggacc cctggcccgg gccttgcagc    360

tggcgctggc cgccttccag ctgctcaacc tgctgggcaa cgtggggctc ttcctgcgct    420

cggatcccag catccgtggc gtgatgctgg ccggccgcgg tctgggccag ggctgggctt    480

actgctacca atgccaaagc caggtgccgc cacgcagcgg acactgctct gcctgccgcg    540

tctgcatcct gcgtcgggac caccactgcc gcctgctggg ccgctgcgtg ggcttcggca    600

actaccggcc cttcctgtgc ctgctgcttc atgccgccgg cgtcctgctc cacgtctctg    660

tgctgctggg ccctgcactg tcggccctgc tgcgagccca cacgcccctc cacatggctg    720

ccctcctcct gcttccctgg ctcatgttgc tcacaggcag agtgtctctg gcacagtttg    780

ccttggcctt cgtgacggac acgtgcgtgg cgggtgcgct gctgtgcggg gctgggctgc    840

tcttccatgg gatgctgctg ctgcggggcc agaccacatg ggagtgggct cggggccagc    900

actcctatga cctgggtccc tgccacaacc tgcaggcagc cctggggccc cgctgggccc    960

tcgtctggct ctggcccttc ctggcctccc cattgcctgg ggatgggatc accttccaga   1020

ccacagcaga tgtgggacac acagcctcct gactccagga agagccagag ctgtgcaggg   1080

aggaaggggt gagagggggg cccccacacc tagactcagt aaggaagtcg ggttggacct   1140

taacatctgc attggacaac tccacccctt ccttggcctt gcccctgccc gcctacactc   1200

ctacgtgtcc agggcttggg ccgtgactta ggcagaggag tgcagaggag ggtctggcag   1260

gggctgctca ggccgcctag ctgccccttt gccaggttaa taaagcactg acttgttaa    1319


<210>  2731
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  2731

Met Gly Gln Pro Trp Ala Ala Gly Ser Thr Asp Gly Ala Pro Ala Gln 
1               5                   10                  15      


Leu Pro Leu Val Leu Thr Ala Leu Trp Ala Ala Ala Val Gly Leu Glu 
            20                  25                  30          


Leu Ala Tyr Val Leu Val Leu Gly Pro Gly Pro Pro Pro Leu Gly Pro 
        35                  40                  45              


Leu Ala Arg Ala Leu Gln Leu Ala Leu Ala Ala Phe Gln Leu Leu Asn 
    50                  55                  60                  


Leu Leu Gly Asn Val Gly Leu Phe Leu Arg Ser Asp Pro Ser Ile Arg 
65                  70                  75                  80  


Gly Val Met Leu Ala Gly Arg Gly Leu Gly Gln Gly Trp Ala Tyr Cys 
                85                  90                  95      


Tyr Gln Cys Gln Ser Gln Val Pro Pro Arg Ser Gly His Cys Ser Ala 
            100                 105                 110         


Cys Arg Val Cys Ile Leu Arg Arg Asp His His Cys Arg Leu Leu Gly 
        115                 120                 125             


Arg Cys Val Gly Phe Gly Asn Tyr Arg Pro Phe Leu Cys Leu Leu Leu 
    130                 135                 140                 


His Ala Ala Gly Val Leu Leu His Val Ser Val Leu Leu Gly Pro Ala 
145                 150                 155                 160 


Leu Ser Ala Leu Leu Arg Ala His Thr Pro Leu His Met Ala Ala Leu 
                165                 170                 175     


Leu Leu Leu Pro Trp Leu Met Leu Leu Thr Gly Arg Val Ser Leu Ala 
            180                 185                 190         


Gln Phe Ala Leu Ala Phe Val Thr Asp Thr Cys Val Ala Gly Ala Leu 
        195                 200                 205             


Leu Cys Gly Ala Gly Leu Leu Phe His Gly Met Leu Leu Leu Arg Gly 
    210                 215                 220                 


Gln Thr Thr Trp Glu Trp Ala Arg Gly Gln His Ser Tyr Asp Leu Gly 
225                 230                 235                 240 


Pro Cys His Asn Leu Gln Ala Ala Leu Gly Pro Arg Trp Ala Leu Val 
                245                 250                 255     


Trp Leu Trp Pro Phe Leu Ala Ser Pro Leu Pro Gly Asp Gly Ile Thr 
            260                 265                 270         


Phe Gln Thr Thr Ala Asp Val Gly His Thr Ala Ser 
        275                 280                 


<210>  2732
<211>  2858
<212>  DNA
<213>  Homosapiens

<400>  2732
gccaggagcc cgatcgagat gatgatggtt atgcagcccg agggtctggg ggccggggag     60

gggcgctttg cgggcggcgg cgggggcggc gagtacatgg aacaggagga ggactgggac    120

cgcgacctgc tgctggaccc ggcctgggag aagcagcagc ggaaaacctt cactgcctgg    180

tgcaactcac acctgcgcaa ggcaggcacc cagatcgaga acatcgagga agatttccgc    240

aatggcctca aactcatgct gctcctggag gtcatttcag gtgagaggct gcctaggcca    300

gataaaggca agatgcgctt ccacaaaatc gccaacgtta acaaggccct ggacttcatt    360

gccagcaagg gggttaaact ggtgtccatt ggtgctgaag agattgttga cgggaacctg    420

aagatgaccc tgggcatgat ctggaccatc atccttcgct tcgccatcca ggacatctct    480

gtggaagaaa cctcagccaa ggaaggcttg cttctgtggt gccagaggaa gacagcaccg    540

taccgcaacg tcaacgtgca gaacttccac accagctgga aggatggcct ggccctctgt    600

gccctcatcc accgacaccg ccctgacctc atcgactacg ccaaactgcg aaaggatgac    660

cccatcggaa acctgaacac tgcctttgag gtggcagaga aatacctgga catccccaag    720

atgttggatg cagaagacat tgtgaacacc ccaaagccgg atgagaaggc catcatgacc    780

tatgtgtcct gcttctacca tgcctttgcc ggggctgagc aggcagagac agctgccaac    840

aggatctgca aggtgctggc agtgaaccag gaaaacgaga agctgatgga ggagtatgag    900

aagcttgcca gtgagctgct ggagtggatc cgccgcactg tcccatggct ggagaaccgt    960

gtgggtgagc ccagcatgag tgccatgcag cgcaaactag aggactttcg ggactaccgg   1020

cgtctgcaca agccgccccg cattcaggaa aagtgccagc tggagatcaa cttcaacaca   1080

ctgcagacca agttgcggct cagccaccgg cctgccttca tgccctccga gggcaagctg   1140

gtctcggaca tcgccaacgc ctggcggggg ctggagcagg tggaaaaggg ctatgaggac   1200

tggctgctct cggagatccg gcgcctgcag cgactccagc acctggctga gaagttccgg   1260

cagaaggcct ccctgcacga agcctggacc cggggaaagg aggagatgct gagccagcgc   1320

gactacgatt cggctttgct acaggaggtg cgggcgttgc tgcggcgcca cgaggccttt   1380

gagagcgacc tggcggcgca ccaggaccgc gtggagcaca ttgccgcgct ggcccaggag   1440

ctcaatgagc tggactacca cgaggcagcc tcagtgaata gccgctgcca ggccatctgc   1500

gatcagtggg acaacctggg caccctgacc cagaagaggc gggatgcgct agagcggatg   1560

gagaagctcc tggagaccat tgaccagctg caactggagt ttgcccggcg ggccgcgccc   1620

ttcaacaact ggctggatgg tgccgtggag gacctgcagg acgtgtggct ggtacactct   1680

gtggaggaga cccagagcct gctgacagcg cacgatcagt tcaaggcaac actgcccgag   1740

gctgaccgag agcgaggtgc catcatgggc atccagggtg agatccagaa gatctgccag   1800

acgtatgggc tgcggccctg ctccaccaat ccctacatca ccctcagccc gcaggacatc   1860

aacaccaagt gggatatggt ccgaaagctg gtgcccagcc gtgaccagac actgcaggag   1920

gagctggcac ggcagcaggt aaacgagagg ctccggcgac agtttgcggc ccaggccaat   1980

gccattggac cctggatcca ggcgaaggtg gaggaagtgg ggcggctggc agcagggcta   2040

gctggctctc tggaggagca gatggctggg ctacggcagc aggagcagaa cattatcaac   2100

tacaagacta acattgaccg gctggagggt gaccaccagc tgctgcagga gagcctggtg   2160

ttcgacaata agcacaccgt ctacagcatg gagcacatcc gcgtgggctg ggagcagctg   2220

ctcacctcca ttgcccgcac catcaatgaa gtggagaacc aggtactgac ccgagacgcc   2280

aagggactga gccaggagca gctcaacgag ttccgagcat ccttcaacca ctttgacagg   2340

aagcggaatg ggatgatgga gcctgatgac ttccgagctt gcctcatctc catgggctat   2400

gacctggggg aagtggagtt tgctcgcatc atgaccatgg tggaccccaa cgcagctggg   2460

gtggtgacct tccaggcctt catagacttc atgacccgag agacagccga gactgacacg   2520

actgagcaag ttgtagcttc cttcaagatc ttggcaggag acaagaacta catcaccccc   2580

gaggagctgc ggcgcgagct ccctgccaag caggccgagt actgcatccg ccgtatggtg   2640

ccctacaagg gatccggggc cccggctgga gccctggact acgtggcctt ctccagtgcc   2700

ctctatgggg agagcgacct ttgaccccaa ccactgaggt tctctatgca agatggagag   2760

aggatgcacc ctgtggctga tcccatccgt ccctcggagc aagggcctaa gagaaaagcc   2820

agccaagtgc ttctgaataa agatccctct ctgggtca                           2858


<210>  2733
<211>  901
<212>  PRT
<213>  Homosapiens

<400>  2733

Met Met Met Val Met Gln Pro Glu Gly Leu Gly Ala Gly Glu Gly Arg 
1               5                   10                  15      


Phe Ala Gly Gly Gly Gly Gly Gly Glu Tyr Met Glu Gln Glu Glu Asp 
            20                  25                  30          


Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp Glu Lys Gln Gln Arg 
        35                  40                  45              


Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu Arg Lys Ala Gly Thr 
    50                  55                  60                  


Gln Ile Glu Asn Ile Glu Glu Asp Phe Arg Asn Gly Leu Lys Leu Met 
65                  70                  75                  80  


Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu Pro Arg Pro Asp Lys 
                85                  90                  95      


Gly Lys Met Arg Phe His Lys Ile Ala Asn Val Asn Lys Ala Leu Asp 
            100                 105                 110         


Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser Ile Gly Ala Glu Glu 
        115                 120                 125             


Ile Val Asp Gly Asn Leu Lys Met Thr Leu Gly Met Ile Trp Thr Ile 
    130                 135                 140                 


Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val Glu Glu Thr Ser Ala 
145                 150                 155                 160 


Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys Thr Ala Pro Tyr Arg 
                165                 170                 175     


Asn Val Asn Val Gln Asn Phe His Thr Ser Trp Lys Asp Gly Leu Ala 
            180                 185                 190         


Leu Cys Ala Leu Ile His Arg His Arg Pro Asp Leu Ile Asp Tyr Ala 
        195                 200                 205             


Lys Leu Arg Lys Asp Asp Pro Ile Gly Asn Leu Asn Thr Ala Phe Glu 
    210                 215                 220                 


Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met Leu Asp Ala Glu Asp 
225                 230                 235                 240 


Ile Val Asn Thr Pro Lys Pro Asp Glu Lys Ala Ile Met Thr Tyr Val 
                245                 250                 255     


Ser Cys Phe Tyr His Ala Phe Ala Gly Ala Glu Gln Ala Glu Thr Ala 
            260                 265                 270         


Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn Gln Glu Asn Glu Lys 
        275                 280                 285             


Leu Met Glu Glu Tyr Glu Lys Leu Ala Ser Glu Leu Leu Glu Trp Ile 
    290                 295                 300                 


Arg Arg Thr Val Pro Trp Leu Glu Asn Arg Val Gly Glu Pro Ser Met 
305                 310                 315                 320 


Ser Ala Met Gln Arg Lys Leu Glu Asp Phe Arg Asp Tyr Arg Arg Leu 
                325                 330                 335     


His Lys Pro Pro Arg Ile Gln Glu Lys Cys Gln Leu Glu Ile Asn Phe 
            340                 345                 350         


Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser His Arg Pro Ala Phe Met 
        355                 360                 365             


Pro Ser Glu Gly Lys Leu Val Ser Asp Ile Ala Asn Ala Trp Arg Gly 
    370                 375                 380                 


Leu Glu Gln Val Glu Lys Gly Tyr Glu Asp Trp Leu Leu Ser Glu Ile 
385                 390                 395                 400 


Arg Arg Leu Gln Arg Leu Gln His Leu Ala Glu Lys Phe Arg Gln Lys 
                405                 410                 415     


Ala Ser Leu His Glu Ala Trp Thr Arg Gly Lys Glu Glu Met Leu Ser 
            420                 425                 430         


Gln Arg Asp Tyr Asp Ser Ala Leu Leu Gln Glu Val Arg Ala Leu Leu 
        435                 440                 445             


Arg Arg His Glu Ala Phe Glu Ser Asp Leu Ala Ala His Gln Asp Arg 
    450                 455                 460                 


Val Glu His Ile Ala Ala Leu Ala Gln Glu Leu Asn Glu Leu Asp Tyr 
465                 470                 475                 480 


His Glu Ala Ala Ser Val Asn Ser Arg Cys Gln Ala Ile Cys Asp Gln 
                485                 490                 495     


Trp Asp Asn Leu Gly Thr Leu Thr Gln Lys Arg Arg Asp Ala Leu Glu 
            500                 505                 510         


Arg Met Glu Lys Leu Leu Glu Thr Ile Asp Gln Leu Gln Leu Glu Phe 
        515                 520                 525             


Ala Arg Arg Ala Ala Pro Phe Asn Asn Trp Leu Asp Gly Ala Val Glu 
    530                 535                 540                 


Asp Leu Gln Asp Val Trp Leu Val His Ser Val Glu Glu Thr Gln Ser 
545                 550                 555                 560 


Leu Leu Thr Ala His Asp Gln Phe Lys Ala Thr Leu Pro Glu Ala Asp 
                565                 570                 575     


Arg Glu Arg Gly Ala Ile Met Gly Ile Gln Gly Glu Ile Gln Lys Ile 
            580                 585                 590         


Cys Gln Thr Tyr Gly Leu Arg Pro Cys Ser Thr Asn Pro Tyr Ile Thr 
        595                 600                 605             


Leu Ser Pro Gln Asp Ile Asn Thr Lys Trp Asp Met Val Arg Lys Leu 
    610                 615                 620                 


Val Pro Ser Arg Asp Gln Thr Leu Gln Glu Glu Leu Ala Arg Gln Gln 
625                 630                 635                 640 


Val Asn Glu Arg Leu Arg Arg Gln Phe Ala Ala Gln Ala Asn Ala Ile 
                645                 650                 655     


Gly Pro Trp Ile Gln Ala Lys Val Glu Glu Val Gly Arg Leu Ala Ala 
            660                 665                 670         


Gly Leu Ala Gly Ser Leu Glu Glu Gln Met Ala Gly Leu Arg Gln Gln 
        675                 680                 685             


Glu Gln Asn Ile Ile Asn Tyr Lys Thr Asn Ile Asp Arg Leu Glu Gly 
    690                 695                 700                 


Asp His Gln Leu Leu Gln Glu Ser Leu Val Phe Asp Asn Lys His Thr 
705                 710                 715                 720 


Val Tyr Ser Met Glu His Ile Arg Val Gly Trp Glu Gln Leu Leu Thr 
                725                 730                 735     


Ser Ile Ala Arg Thr Ile Asn Glu Val Glu Asn Gln Val Leu Thr Arg 
            740                 745                 750         


Asp Ala Lys Gly Leu Ser Gln Glu Gln Leu Asn Glu Phe Arg Ala Ser 
        755                 760                 765             


Phe Asn His Phe Asp Arg Lys Arg Asn Gly Met Met Glu Pro Asp Asp 
    770                 775                 780                 


Phe Arg Ala Cys Leu Ile Ser Met Gly Tyr Asp Leu Gly Glu Val Glu 
785                 790                 795                 800 


Phe Ala Arg Ile Met Thr Met Val Asp Pro Asn Ala Ala Gly Val Val 
                805                 810                 815     


Thr Phe Gln Ala Phe Ile Asp Phe Met Thr Arg Glu Thr Ala Glu Thr 
            820                 825                 830         


Asp Thr Thr Glu Gln Val Val Ala Ser Phe Lys Ile Leu Ala Gly Asp 
        835                 840                 845             


Lys Asn Tyr Ile Thr Pro Glu Glu Leu Arg Arg Glu Leu Pro Ala Lys 
    850                 855                 860                 


Gln Ala Glu Tyr Cys Ile Arg Arg Met Val Pro Tyr Lys Gly Ser Gly 
865                 870                 875                 880 


Ala Pro Ala Gly Ala Leu Asp Tyr Val Ala Phe Ser Ser Ala Leu Tyr 
                885                 890                 895     


Gly Glu Ser Asp Leu 
            900     


<210>  2734
<211>  2168
<212>  DNA
<213>  Homosapiens

<400>  2734
ggaagggatg ggctcgcgct gccgggcgtg ggcgtggact cgggcgtggg cactggcgga     60

gttccaagcc cgggctgagg agggggcggc ggcggcggcg gcggcggcgg cgggcgggta    120

cccttcgact gggcgttgcc gctgttccct gcgcggcatg gaggggacgg ccgtggccgt    180

gttcgagatt ttgagatttt taataattca ctggaagtgt gacatagatg tatcaaaggg    240

agcattgcta gaagggcagc tagtgatttc catagaagga ttaaattcta agcaccaggc    300

aaatgctctt cattgtgtaa caactagatg gagtctcact ctgttaccca ggccggagtg    360

cagtggcgca gtctcggctc actgcaacct ccacctccca ggttcaagtg attctcatgc    420

ctcagtcccc cgagtagctg ggattacaga tgcccaccac catgcctggc taattatggt    480

tgcttctgca ggaagccttt ttggtggcat ggtcctcaag aagttcctaa aagaaataca    540

gtccatactg cccggaatct ctgcaaagct gacttggact tcagaggaag gcagctattc    600

tcaggatatg acaggggtaa cacccttcca gatgattttt gaggttgatg aaaagcccag    660

aaccttgatg acagattgtc tggttataaa gcatttttta cgtaaaatca tcatggtgca    720

ccctaaggtc agatttcatt tcagtgtaaa ggtaaatgga atcctctcca cagagatctt    780

tggggtggag aatgaaccca ctttgaacct tgggaatgga attgctcttt tggtcgactc    840

ccagcattat gtgagaccaa attttggtac aattgaatca cactgcagca gaattcaccc    900

tgtgctagga catccagtaa tgcttttcat ccctgaagac gtggctggca tggacttgtt    960

gggagaactg atactgactc cagcagctgc actgtgcccc agcccaaagg tttcttccaa   1020

ccagcttaac aggatttctt cagtttccat atttctatat ggacctttgg gtctgcctct   1080

gatattgtca acttgggagc agccgatgac tactttcttc aaagatacct cttctttagt   1140

tgactggaaa aaataccatt tgtgtatgat acccaatttg gatctcaatt tggatagaga   1200

tttggtgctt ccagatgtga gttatcaggt ggaatccagt gaggaggatc agtctcagac   1260

tatggatcct caaggacaaa ctctgctgct ttttctcttt gtggatttcc acagtgcatt   1320

tccagtccag caaatggaaa tctggggagt ctatactttg ctcacaactc atctcaatgc   1380

catccttgtg gagagccaca gtgtagtgca aggttccatc caattcactg tggacaaggt   1440

cttggagcaa catcaccagg ctgccaaggc tcagcagaaa ctacaggcct cactctcagt   1500

ggctgtgaac tccatcatga gtattctgac tggaagcact aggagcagct tccgaaagat   1560

gtgtctccag acccttcaag cagctgacac acaagagttc aggaccaaac tgcacaaagt   1620

atttcgtgag atcacccaac accaatttct tcaccactgc tcatgtgagg tgaagcagca   1680

gctaacccta gaaaaaaagg actcagccca gggcactgag gacgcacctg ataacagcag   1740

cctggagctc ctagcagata ccagcgggca agcagaaaac aagaggctca agaggggcag   1800

cccccgcata gaggagatgc gagctctgcg ctctgccagg gccccgagcc cgtcagaggc   1860

cgccccgcgc cgcccggaag ccaccgcggc ccccctcact cctagaggaa gggagcaccg   1920

cgaggctcac ggcagggccc tggcgccggg cagggcgagc ctcggaagcc gcctggagga   1980

cgtgctgtgg ctgcaggagg tctccaacct gtcagagtgg ctgagtccca gccctgggcc   2040

ctgagccggg tccccttccg caagcgccca ccgatccgga ggctgcgggc agccgttatc   2100

ccgtggttta ataaagctgc cgcgcgctca ccaagtccaa aaaaaaaaaa aaaaaaaaaa   2160

aaaaaaaa                                                            2168


<210>  2735
<211>  522
<212>  PRT
<213>  Homosapiens

<400>  2735

Met Val Ala Ser Ala Gly Ser Leu Phe Gly Gly Met Val Leu Lys Lys 
1               5                   10                  15      


Phe Leu Lys Glu Ile Gln Ser Ile Leu Pro Gly Ile Ser Ala Lys Leu 
            20                  25                  30          


Thr Trp Thr Ser Glu Glu Gly Ser Tyr Ser Gln Asp Met Thr Gly Val 
        35                  40                  45              


Thr Pro Phe Gln Met Ile Phe Glu Val Asp Glu Lys Pro Arg Thr Leu 
    50                  55                  60                  


Met Thr Asp Cys Leu Val Ile Lys His Phe Leu Arg Lys Ile Ile Met 
65                  70                  75                  80  


Val His Pro Lys Val Arg Phe His Phe Ser Val Lys Val Asn Gly Ile 
                85                  90                  95      


Leu Ser Thr Glu Ile Phe Gly Val Glu Asn Glu Pro Thr Leu Asn Leu 
            100                 105                 110         


Gly Asn Gly Ile Ala Leu Leu Val Asp Ser Gln His Tyr Val Arg Pro 
        115                 120                 125             


Asn Phe Gly Thr Ile Glu Ser His Cys Ser Arg Ile His Pro Val Leu 
    130                 135                 140                 


Gly His Pro Val Met Leu Phe Ile Pro Glu Asp Val Ala Gly Met Asp 
145                 150                 155                 160 


Leu Leu Gly Glu Leu Ile Leu Thr Pro Ala Ala Ala Leu Cys Pro Ser 
                165                 170                 175     


Pro Lys Val Ser Ser Asn Gln Leu Asn Arg Ile Ser Ser Val Ser Ile 
            180                 185                 190         


Phe Leu Tyr Gly Pro Leu Gly Leu Pro Leu Ile Leu Ser Thr Trp Glu 
        195                 200                 205             


Gln Pro Met Thr Thr Phe Phe Lys Asp Thr Ser Ser Leu Val Asp Trp 
    210                 215                 220                 


Lys Lys Tyr His Leu Cys Met Ile Pro Asn Leu Asp Leu Asn Leu Asp 
225                 230                 235                 240 


Arg Asp Leu Val Leu Pro Asp Val Ser Tyr Gln Val Glu Ser Ser Glu 
                245                 250                 255     


Glu Asp Gln Ser Gln Thr Met Asp Pro Gln Gly Gln Thr Leu Leu Leu 
            260                 265                 270         


Phe Leu Phe Val Asp Phe His Ser Ala Phe Pro Val Gln Gln Met Glu 
        275                 280                 285             


Ile Trp Gly Val Tyr Thr Leu Leu Thr Thr His Leu Asn Ala Ile Leu 
    290                 295                 300                 


Val Glu Ser His Ser Val Val Gln Gly Ser Ile Gln Phe Thr Val Asp 
305                 310                 315                 320 


Lys Val Leu Glu Gln His His Gln Ala Ala Lys Ala Gln Gln Lys Leu 
                325                 330                 335     


Gln Ala Ser Leu Ser Val Ala Val Asn Ser Ile Met Ser Ile Leu Thr 
            340                 345                 350         


Gly Ser Thr Arg Ser Ser Phe Arg Lys Met Cys Leu Gln Thr Leu Gln 
        355                 360                 365             


Ala Ala Asp Thr Gln Glu Phe Arg Thr Lys Leu His Lys Val Phe Arg 
    370                 375                 380                 


Glu Ile Thr Gln His Gln Phe Leu His His Cys Ser Cys Glu Val Lys 
385                 390                 395                 400 


Gln Gln Leu Thr Leu Glu Lys Lys Asp Ser Ala Gln Gly Thr Glu Asp 
                405                 410                 415     


Ala Pro Asp Asn Ser Ser Leu Glu Leu Leu Ala Asp Thr Ser Gly Gln 
            420                 425                 430         


Ala Glu Asn Lys Arg Leu Lys Arg Gly Ser Pro Arg Ile Glu Glu Met 
        435                 440                 445             


Arg Ala Leu Arg Ser Ala Arg Ala Pro Ser Pro Ser Glu Ala Ala Pro 
    450                 455                 460                 


Arg Arg Pro Glu Ala Thr Ala Ala Pro Leu Thr Pro Arg Gly Arg Glu 
465                 470                 475                 480 


His Arg Glu Ala His Gly Arg Ala Leu Ala Pro Gly Arg Ala Ser Leu 
                485                 490                 495     


Gly Ser Arg Leu Glu Asp Val Leu Trp Leu Gln Glu Val Ser Asn Leu 
            500                 505                 510         


Ser Glu Trp Leu Ser Pro Ser Pro Gly Pro 
        515                 520         


<210>  2736
<211>  1485
<212>  DNA
<213>  Homosapiens

<400>  2736
tccctgggac tgcgtcactg gtgcgcgccg cgggtcaggg cgcaatggcg gcgctgggcg     60

gggatgggct gcgactgctg tcggtgtcgc ggccggagcg gccgcccgag tcggcggcgc    120

tgggcggcct gggccccggg ctgtgctgct gggtgtcagt gttctcctgc ctcagcctcg    180

cctgctccta cgtgggcagc ctctacgtct ggaagagcga actgcccagg gaccatcccg    240

cggtcatcaa gcgacgcttc accagcgtcc tggtggtgtc cagtctctca cccctgtgcg    300

tgctgctctg gagggaactc acaggcatcc aggcacatcc ctgctcaccc tgatgggctt    360

caggctggag ggcattttcc cagcggcgct gctgcccctg ttgctgacca tgattctttt    420

cctgggccca ctgatgcagc tctctatgga ttgcccttgt gacctggcag atgggctgaa    480

ggttgtcctg gccccccgct cctgggcccg ctgcctcaca gacatgcgtt ggctgcggaa    540

ccaagtgatc gccccgctga cagaggagct ggtgttccgg gcctgtatgc tgcccatgtt    600

agcaccgtgc atgggcctgg gccctgctgt gttcacctgc ccgctctttt ttggagttgc    660

ccattttcac catattattg agcagctgcg tttccgccag agcagcgtgg ggaacatctt    720

cttgtctgct gcgttccagt tctcctacac agctgtcttc ggtgcctaca ctgctttcct    780

cttcatccgc acaggacacc tgattgggcc ggttctctgc cattccttct gcaattacat    840

gggtttccca gctgtttgcg cggccttgga gcacccacag aggcggcccc tgctggcagg    900

ctatgccctg ggtgtgggac tcttcctgct tctgctccag cccctcacgg accccaagct    960

ctacggcagc cttccccttt gtgtgctttt ggagcgggca ggggactcag aggctcccct   1020

gtgctcctga cctatgctcc tggatacgct atgaactctc accggctccc cagccctccc   1080

caccaagggg tactgcaggg gaagggctgg ctggggtccc cgagatctca ggaatttttg   1140

taggggattg aagccagagc tagttgcgtc ccagggacca agagaaagaa gcagatatcc   1200

aaagggtgca gccccttttg aaaggggtgt ttacgagcag ctgtgagtga ggggacaagg   1260

ggcaggtccc aggagccaca cactcccttc ctcactttgg actgctgctt ctcttagctc   1320

ctctgcctct gaaaagctgc tcggggtttt ttatttataa aacctctccc caccccccac   1380

cccccaactt cctgggtttt ctcattgtct ttttgcatca gtactttgta ttgggatatt   1440

aaagagattt aacttgggta acatggcaaa aaaaaaaaaa aaaaa                   1485


<210>  2737
<211>  225
<212>  PRT
<213>  Homosapiens

<400>  2737

Met Gly Phe Arg Leu Glu Gly Ile Phe Pro Ala Ala Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Thr Met Ile Leu Phe Leu Gly Pro Leu Met Gln Leu Ser Met 
            20                  25                  30          


Asp Cys Pro Cys Asp Leu Ala Asp Gly Leu Lys Val Val Leu Ala Pro 
        35                  40                  45              


Arg Ser Trp Ala Arg Cys Leu Thr Asp Met Arg Trp Leu Arg Asn Gln 
    50                  55                  60                  


Val Ile Ala Pro Leu Thr Glu Glu Leu Val Phe Arg Ala Cys Met Leu 
65                  70                  75                  80  


Pro Met Leu Ala Pro Cys Met Gly Leu Gly Pro Ala Val Phe Thr Cys 
                85                  90                  95      


Pro Leu Phe Phe Gly Val Ala His Phe His His Ile Ile Glu Gln Leu 
            100                 105                 110         


Arg Phe Arg Gln Ser Ser Val Gly Asn Ile Phe Leu Ser Ala Ala Phe 
        115                 120                 125             


Gln Phe Ser Tyr Thr Ala Val Phe Gly Ala Tyr Thr Ala Phe Leu Phe 
    130                 135                 140                 


Ile Arg Thr Gly His Leu Ile Gly Pro Val Leu Cys His Ser Phe Cys 
145                 150                 155                 160 


Asn Tyr Met Gly Phe Pro Ala Val Cys Ala Ala Leu Glu His Pro Gln 
                165                 170                 175     


Arg Arg Pro Leu Leu Ala Gly Tyr Ala Leu Gly Val Gly Leu Phe Leu 
            180                 185                 190         


Leu Leu Leu Gln Pro Leu Thr Asp Pro Lys Leu Tyr Gly Ser Leu Pro 
        195                 200                 205             


Leu Cys Val Leu Leu Glu Arg Ala Gly Asp Ser Glu Ala Pro Leu Cys 
    210                 215                 220                 


Ser 
225 


<210>  2738
<211>  1489
<212>  DNA
<213>  Homosapiens

<400>  2738
tccctgggac tgcgtcactg gtgcgcgccg cgggtcaggg cgcaatggcg gcgctgggcg     60

gggatgggct gcgactgctg tcggtgtcgc ggccggagcg gccgcccgag tcggcggcgc    120

tgggcggcct gggccccggg ctgtgctgct gggtgtcagt gttctcctgc ctcagcctcg    180

cctgctccta cgtgggcagc ctctacgtct ggaagagcga actgcccagg gaccatcccg    240

cggtcatcaa gcgacgcttc accagcgtcc tggtggtgtc cagtctctca cccctgtgcg    300

tgctgctctg gagggaactc acaggcatcc agccaggcac atccctgctc accctgatgg    360

gcttcaggct ggagggcatt ttcccagcgg cgctgctgcc cctgttgctg accatgattc    420

ttttcctggg cccactgatg cagctctcta tggattgccc ttgtgacctg gcagatgggc    480

tgaaggttgt cctggccccc cgctcctggg cccgctgcct cacagacatg cgttggctgc    540

ggaaccaagt gatcgccccg ctgacagagg agctggtgtt ccgggcctgt atgctgccca    600

tgttagcacc gtgcatgggc ctgggccctg ctgtgttcac ctgcccgctc ttttttggag    660

ttgcccattt tcaccatatt attgagcagc tgcgtttccg ccagagcagc gtggggaaca    720

tcttcttgtc tgctgcgttc cagttctcct acacagctgt cttcggtgcc tacactgctt    780

tcctcttcat ccgcacagga cacctgattg ggccggttct ctgccattcc ttctgcaatt    840

acatgggttt cccagctgtt tgcgcggcct tggagcaccc acagaggcgg cccctgctgg    900

caggctatgc cctgggtgtg ggactcttcc tgcttctgct ccagcccctc acggacccca    960

agctctacgg cagccttccc ctttgtgtgc ttttggagcg ggcaggggac tcagaggctc   1020

ccctgtgctc ctgacctatg ctcctggata cgctatgaac tctcaccggc tccccagccc   1080

tccccaccaa ggggtactgc aggggaaggg ctggctgggg tccccgagat ctcaggaatt   1140

tttgtagggg attgaagcca gagctagttg cgtcccaggg accaagagaa agaagcagat   1200

atccaaaggg tgcagcccct tttgaaaggg gtgtttacga gcagctgtga gtgaggggac   1260

aaggggcagg tcccaggagc cacacactcc cttcctcact ttggactgct gcttctctta   1320

gctcctctgc ctctgaaaag ctgctcgggg ttttttattt ataaaacctc tccccacccc   1380

ccacccccca acttcctggg ttttctcatt gtctttttgc atcagtactt tgtattggga   1440

tattaaagag atttaacttg ggtaacatgg caaaaaaaaa aaaaaaaaa               1489


<210>  2739
<211>  329
<212>  PRT
<213>  Homosapiens

<400>  2739

Met Ala Ala Leu Gly Gly Asp Gly Leu Arg Leu Leu Ser Val Ser Arg 
1               5                   10                  15      


Pro Glu Arg Pro Pro Glu Ser Ala Ala Leu Gly Gly Leu Gly Pro Gly 
            20                  25                  30          


Leu Cys Cys Trp Val Ser Val Phe Ser Cys Leu Ser Leu Ala Cys Ser 
        35                  40                  45              


Tyr Val Gly Ser Leu Tyr Val Trp Lys Ser Glu Leu Pro Arg Asp His 
    50                  55                  60                  


Pro Ala Val Ile Lys Arg Arg Phe Thr Ser Val Leu Val Val Ser Ser 
65                  70                  75                  80  


Leu Ser Pro Leu Cys Val Leu Leu Trp Arg Glu Leu Thr Gly Ile Gln 
                85                  90                  95      


Pro Gly Thr Ser Leu Leu Thr Leu Met Gly Phe Arg Leu Glu Gly Ile 
            100                 105                 110         


Phe Pro Ala Ala Leu Leu Pro Leu Leu Leu Thr Met Ile Leu Phe Leu 
        115                 120                 125             


Gly Pro Leu Met Gln Leu Ser Met Asp Cys Pro Cys Asp Leu Ala Asp 
    130                 135                 140                 


Gly Leu Lys Val Val Leu Ala Pro Arg Ser Trp Ala Arg Cys Leu Thr 
145                 150                 155                 160 


Asp Met Arg Trp Leu Arg Asn Gln Val Ile Ala Pro Leu Thr Glu Glu 
                165                 170                 175     


Leu Val Phe Arg Ala Cys Met Leu Pro Met Leu Ala Pro Cys Met Gly 
            180                 185                 190         


Leu Gly Pro Ala Val Phe Thr Cys Pro Leu Phe Phe Gly Val Ala His 
        195                 200                 205             


Phe His His Ile Ile Glu Gln Leu Arg Phe Arg Gln Ser Ser Val Gly 
    210                 215                 220                 


Asn Ile Phe Leu Ser Ala Ala Phe Gln Phe Ser Tyr Thr Ala Val Phe 
225                 230                 235                 240 


Gly Ala Tyr Thr Ala Phe Leu Phe Ile Arg Thr Gly His Leu Ile Gly 
                245                 250                 255     


Pro Val Leu Cys His Ser Phe Cys Asn Tyr Met Gly Phe Pro Ala Val 
            260                 265                 270         


Cys Ala Ala Leu Glu His Pro Gln Arg Arg Pro Leu Leu Ala Gly Tyr 
        275                 280                 285             


Ala Leu Gly Val Gly Leu Phe Leu Leu Leu Leu Gln Pro Leu Thr Asp 
    290                 295                 300                 


Pro Lys Leu Tyr Gly Ser Leu Pro Leu Cys Val Leu Leu Glu Arg Ala 
305                 310                 315                 320 


Gly Asp Ser Glu Ala Pro Leu Cys Ser 
                325                 


<210>  2740
<211>  4004
<212>  DNA
<213>  Homosapiens

<400>  2740
gtcagtggag gcagcagcgg tagaggcggc ggcgaggact ggcgacggcg aggagatagt     60

gtctgccttc tggagagctg accaaacact aaggatgctg aagttccgaa cagtccatgg    120

gggcctgagg ctcctgggaa tccgccgaac ctccaccgcc cccgctgcct ccccaaatgt    180

ccggcgcctg gagtataagc ccatcaagaa agtcatggtg gccaacagag gtgagattgc    240

catccgtgtg ttccgggcct gcacggagct gggcatccgc accgtagcca tctactctga    300

gcaggacacg ggccagatgc accggcagaa agcagatgaa gcctatctca tcggccgcgg    360

cctggccccc gtgcaggcct acctgcacat cccagacatc atcaaggtgg ccaaggagaa    420

caacgtagat gcagtgcacc ctggctacgg gttcctctct gagcgagcgg acttcgccca    480

ggcctgccag gatgcagggg tccggtttat tgggccaagc ccagaagtgg tccgcaagat    540

gggagacaag gtggaggccc gggccatcgc cattgctgcg ggtgttcccg ttgtccctgg    600

cacagatgcc cccatcacgt ccctgcatga ggcccacgag ttctccaaca cctacggctt    660

ccccatcatc ttcaaggcgg cctatggggg tggagggcgt ggcatgaggg tggtgcacag    720

ctacgaggag ctggaggaga attacacccg ggcctactca gaggctctgg ccgcctttgg    780

gaatggggcg ctgtttgtgg agaagttcat cgagaagcca cggcacatcg aggtgcagat    840

cttgggggac cagtatggga acatcctgca cctgtacgag cgagactgct ccatccagcg    900

gcggcaccag aaggtggtcg agattgcccc cgccgcccac ctggacccgc agcttcggac    960

tcggctcacc agcgactctg tgaaactcgc taaacaggtg ggctacgaga acgcaggcac   1020

cgtggagttc ctggtggaca ggcacggcaa gcactacttc atcgaggtca actcccgcct   1080

gcaggtggag cacacggtca cagaggagat caccgacgta gacctggtcc atgctcagat   1140

ccacgtggct gagggcagga gcctacccga cctgggcctg cggcaggaga acatccgcat   1200

caacgggtgt gccatccagt gccgggtcac caccgaggac cccgcgcgca gcttccagcc   1260

ggacaccggc cgcattgagg tgttccggag cggagagggc atgggcatcc gcctggataa   1320

tgcttccgcc ttccaaggag ccgtcatctc gccccactac gactccctgc tggtcaaagt   1380

cattgcccac ggcaaagacc accccacggc cgccaccaag atgagcaggg cccttgcgga   1440

gttccgcgtc cgaggtgtga agaccaacat cgccttcctg cagaatgtgc tcaacaacca   1500

gcagttcctg gcaggcactg tggacaccca gttcatcgac gagaacccag agctgttcca   1560

gctgcggcct gcacagaacc gggcccaaaa gctgttgcac tacctcggcc atgtcatggt   1620

aaacggtcca accaccccga ttcccgtcaa ggccagcccc agccccacgg accccgttgt   1680

ccctgcagtg cccataggcc cgcccccggc tggtttcaga gacatcctgc tgcgagaggg   1740

gcctgagggc tttgctcgag ctgtgcggaa ccacccgggg ctgctgctga tggacacgac   1800

cttcagggac gcccaccagt cactgctggc cactcgtgtg cgcacccacg atctcaaaaa   1860

gatcgccccc tatgttgccc acaacttcag caagctcttc agcatggaga actggggagg   1920

agccacgttt gacgtcgcca tgcgcttcct gtatgagtgc ccctggcggc ggctgcagga   1980

gctccgggag ctcatcccca acatcccttt ccagatgctg ctgcgggggg ccaatgctgt   2040

gggctacacc aactacccag acaacgtggt cttcaagttc tgtgaagtgg ccaaagagaa   2100

tggcatggat gtcttccgtg tgtttgactc cctcaactac ttgcccaaca tgctgctggg   2160

catggaggcg gcaggaagtg ccggaggcgt ggtggaggct gccatctcat acacgggcga   2220

cgtggccgac cccagccgca ccaagtactc actgcagtac tacatgggct tggccgaaga   2280

gctggtgcga gctggcaccc acatcctgtg catcaaggac atggccgggc tgctgaagcc   2340

cacggcctgc accatgctgg tcagctccct ccgggaccgc ttccccgacc tcccactgca   2400

catccacacc cacgacacgt caggggcagg cgtggcagcc atgctggcct gtgcccaggc   2460

tggagctgat gtggtggatg tggcagctga ttccatgtct gggatgactt cacagcccag   2520

catgggggcc ctggtggcct gtaccagagg gactcccctg gacacagagg tgcccatgga   2580

gcgcgtgttt gactacagtg agtactggga gggggctcgg ggactgtacg cggccttcga   2640

ctgcacggcc accatgaagt ctggcaactc ggacgtgtat gaaaatgaga tcccaggggg   2700

ccagtacacc aacctgcact tccaggccca cagcatgggg cttggctcca agttcaagga   2760

ggtcaagaag gcctatgtgg aggccaacca gatgctgggc gatctcatca aggtgacgcc   2820

ctcctccaag atcgtggggg acctggccca gtttatggtg cagaatggat tgagccgggc   2880

agaggccgaa gctcaggcgg aagagctgtc ctttccccgc tccgtggtgg agttcctgca   2940

gggctacatc ggtgtccccc atggggggtt ccccgaaccc tttcgctcta aggtactgaa   3000

ggacctgcca agggtggagg ggcggcctgg agcctccctc cctcccctgg atctgcaggc   3060

actggagaag gagctggtag accggcatgg ggaggaggtg acgccggaag atgtgctctc   3120

agcagctatg taccccgatg tgtttgccca cttcaaggac ttcactgcca cctttggccc   3180

cctggatagc ctgaatactc gcctcttcct gcagggaccc aagatcgcag aggagtttga   3240

ggtggagctg gagcggggca agacgctgca catcaaagcc ctggccgtga gcgacctgaa   3300

ccgggccggc cagaggcagg tcttctttga gctcaatggg cagctgcggt ccatcttggt   3360

caaggacacc caggccatga aggagatgca cttccacccc aaggccctaa aggacgtgaa   3420

gggccagatc ggggcgccca tgcctgggaa ggtgatagac atcaaagtgg tggcaggggc   3480

caaggtggcc aagggccagc ccctgtgtgt gctcagtgcc atgaagatgg agactgtggt   3540

gacctcaccc atggagggta ctgtccgcaa ggttcatgtg accaaggaca tgacactgga   3600

aggtgacgac ctcatcctgg agatcgagtg atcttgcccc agaccggcag cctggccatc   3660

cccaagcctt caacagaagc tgtgctgcca cggcaggccc aggccagcca gtgcccgagg   3720

ccaggaaggc cgggccgtgg aggtcctgtc cacagctgga caggagagac accgcctgcg   3780

gtggttcatt cctttcagcc atcgtccttt cctccggcgg acagctgctt acatgttcat   3840

ctcttgccaa ataagggtcc cctcctcact ggagactaca agtggtgggt caggtggtcc   3900

taggacccag gggaggttta ggggtcctat ctcctggggg aaggggagat ctaagatgtc   3960

ccaggtcctg ggaagtttac tcaataaagc tggctttccc ctgc                    4004


<210>  2741
<211>  1178
<212>  PRT
<213>  Homosapiens

<400>  2741

Met Leu Lys Phe Arg Thr Val His Gly Gly Leu Arg Leu Leu Gly Ile 
1               5                   10                  15      


Arg Arg Thr Ser Thr Ala Pro Ala Ala Ser Pro Asn Val Arg Arg Leu 
            20                  25                  30          


Glu Tyr Lys Pro Ile Lys Lys Val Met Val Ala Asn Arg Gly Glu Ile 
        35                  40                  45              


Ala Ile Arg Val Phe Arg Ala Cys Thr Glu Leu Gly Ile Arg Thr Val 
    50                  55                  60                  


Ala Ile Tyr Ser Glu Gln Asp Thr Gly Gln Met His Arg Gln Lys Ala 
65                  70                  75                  80  


Asp Glu Ala Tyr Leu Ile Gly Arg Gly Leu Ala Pro Val Gln Ala Tyr 
                85                  90                  95      


Leu His Ile Pro Asp Ile Ile Lys Val Ala Lys Glu Asn Asn Val Asp 
            100                 105                 110         


Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Arg Ala Asp Phe Ala 
        115                 120                 125             


Gln Ala Cys Gln Asp Ala Gly Val Arg Phe Ile Gly Pro Ser Pro Glu 
    130                 135                 140                 


Val Val Arg Lys Met Gly Asp Lys Val Glu Ala Arg Ala Ile Ala Ile 
145                 150                 155                 160 


Ala Ala Gly Val Pro Val Val Pro Gly Thr Asp Ala Pro Ile Thr Ser 
                165                 170                 175     


Leu His Glu Ala His Glu Phe Ser Asn Thr Tyr Gly Phe Pro Ile Ile 
            180                 185                 190         


Phe Lys Ala Ala Tyr Gly Gly Gly Gly Arg Gly Met Arg Val Val His 
        195                 200                 205             


Ser Tyr Glu Glu Leu Glu Glu Asn Tyr Thr Arg Ala Tyr Ser Glu Ala 
    210                 215                 220                 


Leu Ala Ala Phe Gly Asn Gly Ala Leu Phe Val Glu Lys Phe Ile Glu 
225                 230                 235                 240 


Lys Pro Arg His Ile Glu Val Gln Ile Leu Gly Asp Gln Tyr Gly Asn 
                245                 250                 255     


Ile Leu His Leu Tyr Glu Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
            260                 265                 270         


Lys Val Val Glu Ile Ala Pro Ala Ala His Leu Asp Pro Gln Leu Arg 
        275                 280                 285             


Thr Arg Leu Thr Ser Asp Ser Val Lys Leu Ala Lys Gln Val Gly Tyr 
    290                 295                 300                 


Glu Asn Ala Gly Thr Val Glu Phe Leu Val Asp Arg His Gly Lys His 
305                 310                 315                 320 


Tyr Phe Ile Glu Val Asn Ser Arg Leu Gln Val Glu His Thr Val Thr 
                325                 330                 335     


Glu Glu Ile Thr Asp Val Asp Leu Val His Ala Gln Ile His Val Ala 
            340                 345                 350         


Glu Gly Arg Ser Leu Pro Asp Leu Gly Leu Arg Gln Glu Asn Ile Arg 
        355                 360                 365             


Ile Asn Gly Cys Ala Ile Gln Cys Arg Val Thr Thr Glu Asp Pro Ala 
    370                 375                 380                 


Arg Ser Phe Gln Pro Asp Thr Gly Arg Ile Glu Val Phe Arg Ser Gly 
385                 390                 395                 400 


Glu Gly Met Gly Ile Arg Leu Asp Asn Ala Ser Ala Phe Gln Gly Ala 
                405                 410                 415     


Val Ile Ser Pro His Tyr Asp Ser Leu Leu Val Lys Val Ile Ala His 
            420                 425                 430         


Gly Lys Asp His Pro Thr Ala Ala Thr Lys Met Ser Arg Ala Leu Ala 
        435                 440                 445             


Glu Phe Arg Val Arg Gly Val Lys Thr Asn Ile Ala Phe Leu Gln Asn 
    450                 455                 460                 


Val Leu Asn Asn Gln Gln Phe Leu Ala Gly Thr Val Asp Thr Gln Phe 
465                 470                 475                 480 


Ile Asp Glu Asn Pro Glu Leu Phe Gln Leu Arg Pro Ala Gln Asn Arg 
                485                 490                 495     


Ala Gln Lys Leu Leu His Tyr Leu Gly His Val Met Val Asn Gly Pro 
            500                 505                 510         


Thr Thr Pro Ile Pro Val Lys Ala Ser Pro Ser Pro Thr Asp Pro Val 
        515                 520                 525             


Val Pro Ala Val Pro Ile Gly Pro Pro Pro Ala Gly Phe Arg Asp Ile 
    530                 535                 540                 


Leu Leu Arg Glu Gly Pro Glu Gly Phe Ala Arg Ala Val Arg Asn His 
545                 550                 555                 560 


Pro Gly Leu Leu Leu Met Asp Thr Thr Phe Arg Asp Ala His Gln Ser 
                565                 570                 575     


Leu Leu Ala Thr Arg Val Arg Thr His Asp Leu Lys Lys Ile Ala Pro 
            580                 585                 590         


Tyr Val Ala His Asn Phe Ser Lys Leu Phe Ser Met Glu Asn Trp Gly 
        595                 600                 605             


Gly Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Cys Pro Trp 
    610                 615                 620                 


Arg Arg Leu Gln Glu Leu Arg Glu Leu Ile Pro Asn Ile Pro Phe Gln 
625                 630                 635                 640 


Met Leu Leu Arg Gly Ala Asn Ala Val Gly Tyr Thr Asn Tyr Pro Asp 
                645                 650                 655     


Asn Val Val Phe Lys Phe Cys Glu Val Ala Lys Glu Asn Gly Met Asp 
            660                 665                 670         


Val Phe Arg Val Phe Asp Ser Leu Asn Tyr Leu Pro Asn Met Leu Leu 
        675                 680                 685             


Gly Met Glu Ala Ala Gly Ser Ala Gly Gly Val Val Glu Ala Ala Ile 
    690                 695                 700                 


Ser Tyr Thr Gly Asp Val Ala Asp Pro Ser Arg Thr Lys Tyr Ser Leu 
705                 710                 715                 720 


Gln Tyr Tyr Met Gly Leu Ala Glu Glu Leu Val Arg Ala Gly Thr His 
                725                 730                 735     


Ile Leu Cys Ile Lys Asp Met Ala Gly Leu Leu Lys Pro Thr Ala Cys 
            740                 745                 750         


Thr Met Leu Val Ser Ser Leu Arg Asp Arg Phe Pro Asp Leu Pro Leu 
        755                 760                 765             


His Ile His Thr His Asp Thr Ser Gly Ala Gly Val Ala Ala Met Leu 
    770                 775                 780                 


Ala Cys Ala Gln Ala Gly Ala Asp Val Val Asp Val Ala Ala Asp Ser 
785                 790                 795                 800 


Met Ser Gly Met Thr Ser Gln Pro Ser Met Gly Ala Leu Val Ala Cys 
                805                 810                 815     


Thr Arg Gly Thr Pro Leu Asp Thr Glu Val Pro Met Glu Arg Val Phe 
            820                 825                 830         


Asp Tyr Ser Glu Tyr Trp Glu Gly Ala Arg Gly Leu Tyr Ala Ala Phe 
        835                 840                 845             


Asp Cys Thr Ala Thr Met Lys Ser Gly Asn Ser Asp Val Tyr Glu Asn 
    850                 855                 860                 


Glu Ile Pro Gly Gly Gln Tyr Thr Asn Leu His Phe Gln Ala His Ser 
865                 870                 875                 880 


Met Gly Leu Gly Ser Lys Phe Lys Glu Val Lys Lys Ala Tyr Val Glu 
                885                 890                 895     


Ala Asn Gln Met Leu Gly Asp Leu Ile Lys Val Thr Pro Ser Ser Lys 
            900                 905                 910         


Ile Val Gly Asp Leu Ala Gln Phe Met Val Gln Asn Gly Leu Ser Arg 
        915                 920                 925             


Ala Glu Ala Glu Ala Gln Ala Glu Glu Leu Ser Phe Pro Arg Ser Val 
    930                 935                 940                 


Val Glu Phe Leu Gln Gly Tyr Ile Gly Val Pro His Gly Gly Phe Pro 
945                 950                 955                 960 


Glu Pro Phe Arg Ser Lys Val Leu Lys Asp Leu Pro Arg Val Glu Gly 
                965                 970                 975     


Arg Pro Gly Ala Ser Leu Pro Pro Leu Asp Leu Gln Ala Leu Glu Lys 
            980                 985                 990         


Glu Leu Val Asp Arg His Gly Glu  Glu Val Thr Pro Glu  Asp Val Leu 
        995                 1000                 1005             


Ser Ala  Ala Met Tyr Pro Asp  Val Phe Ala His Phe  Lys Asp Phe 
    1010                 1015                 1020             


Thr Ala  Thr Phe Gly Pro Leu  Asp Ser Leu Asn Thr  Arg Leu Phe 
    1025                 1030                 1035             


Leu Gln  Gly Pro Lys Ile Ala  Glu Glu Phe Glu Val  Glu Leu Glu 
    1040                 1045                 1050             


Arg Gly  Lys Thr Leu His Ile  Lys Ala Leu Ala Val  Ser Asp Leu 
    1055                 1060                 1065             


Asn Arg  Ala Gly Gln Arg Gln  Val Phe Phe Glu Leu  Asn Gly Gln 
    1070                 1075                 1080             


Leu Arg  Ser Ile Leu Val Lys  Asp Thr Gln Ala Met  Lys Glu Met 
    1085                 1090                 1095             


His Phe  His Pro Lys Ala Leu  Lys Asp Val Lys Gly  Gln Ile Gly 
    1100                 1105                 1110             


Ala Pro  Met Pro Gly Lys Val  Ile Asp Ile Lys Val  Val Ala Gly 
    1115                 1120                 1125             


Ala Lys  Val Ala Lys Gly Gln  Pro Leu Cys Val Leu  Ser Ala Met 
    1130                 1135                 1140             


Lys Met  Glu Thr Val Val Thr  Ser Pro Met Glu Gly  Thr Val Arg 
    1145                 1150                 1155             


Lys Val  His Val Thr Lys Asp  Met Thr Leu Glu Gly  Asp Asp Leu 
    1160                 1165                 1170             


Ile Leu  Glu Ile Glu 
    1175             


<210>  2742
<211>  4192
<212>  DNA
<213>  Homosapiens

<400>  2742
gtcagtggag gcagcagcgg tagaggcggc ggcgaggact ggcgacggcg aggagctgcc     60

ttctagtctc acctgtggac actttgccaa aggagtcggg cctgacggtg gaagatggga    120

aatggccaaa agaataaacc atttcctctt acttaccgaa tgaaaagctt gcttcatctt    180

ggcgttcaag actctctaat atgattccac ctgttgggct ctttcttcca tttgcctccg    240

cagatagtgt ctgccttctg gagagctgac caaacactaa ggatgctgaa gttccgaaca    300

gtccatgggg gcctgaggct cctgggaatc cgccgaacct ccaccgcccc cgctgcctcc    360

ccaaatgtcc ggcgcctgga gtataagccc atcaagaaag tcatggtggc caacagaggt    420

gagattgcca tccgtgtgtt ccgggcctgc acggagctgg gcatccgcac cgtagccatc    480

tactctgagc aggacacggg ccagatgcac cggcagaaag cagatgaagc ctatctcatc    540

ggccgcggcc tggcccccgt gcaggcctac ctgcacatcc cagacatcat caaggtggcc    600

aaggagaaca acgtagatgc agtgcaccct ggctacgggt tcctctctga gcgagcggac    660

ttcgcccagg cctgccagga tgcaggggtc cggtttattg ggccaagccc agaagtggtc    720

cgcaagatgg gagacaaggt ggaggcccgg gccatcgcca ttgctgcggg tgttcccgtt    780

gtccctggca cagatgcccc catcacgtcc ctgcatgagg cccacgagtt ctccaacacc    840

tacggcttcc ccatcatctt caaggcggcc tatgggggtg gagggcgtgg catgagggtg    900

gtgcacagct acgaggagct ggaggagaat tacacccggg cctactcaga ggctctggcc    960

gcctttggga atggggcgct gtttgtggag aagttcatcg agaagccacg gcacatcgag   1020

gtgcagatct tgggggacca gtatgggaac atcctgcacc tgtacgagcg agactgctcc   1080

atccagcggc ggcaccagaa ggtggtcgag attgcccccg ccgcccacct ggacccgcag   1140

cttcggactc ggctcaccag cgactctgtg aaactcgcta aacaggtggg ctacgagaac   1200

gcaggcaccg tggagttcct ggtggacagg cacggcaagc actacttcat cgaggtcaac   1260

tcccgcctgc aggtggagca cacggtcaca gaggagatca ccgacgtaga cctggtccat   1320

gctcagatcc acgtggctga gggcaggagc ctacccgacc tgggcctgcg gcaggagaac   1380

atccgcatca acgggtgtgc catccagtgc cgggtcacca ccgaggaccc cgcgcgcagc   1440

ttccagccgg acaccggccg cattgaggtg ttccggagcg gagagggcat gggcatccgc   1500

ctggataatg cttccgcctt ccaaggagcc gtcatctcgc cccactacga ctccctgctg   1560

gtcaaagtca ttgcccacgg caaagaccac cccacggccg ccaccaagat gagcagggcc   1620

cttgcggagt tccgcgtccg aggtgtgaag accaacatcg ccttcctgca gaatgtgctc   1680

aacaaccagc agttcctggc aggcactgtg gacacccagt tcatcgacga gaacccagag   1740

ctgttccagc tgcggcctgc acagaaccgg gcccaaaagc tgttgcacta cctcggccat   1800

gtcatggtaa acggtccaac caccccgatt cccgtcaagg ccagccccag ccccacggac   1860

cccgttgtcc ctgcagtgcc cataggcccg cccccggctg gtttcagaga catcctgctg   1920

cgagaggggc ctgagggctt tgctcgagct gtgcggaacc acccggggct gctgctgatg   1980

gacacgacct tcagggacgc ccaccagtca ctgctggcca ctcgtgtgcg cacccacgat   2040

ctcaaaaaga tcgcccccta tgttgcccac aacttcagca agctcttcag catggagaac   2100

tggggaggag ccacgtttga cgtcgccatg cgcttcctgt atgagtgccc ctggcggcgg   2160

ctgcaggagc tccgggagct catccccaac atccctttcc agatgctgct gcggggggcc   2220

aatgctgtgg gctacaccaa ctacccagac aacgtggtct tcaagttctg tgaagtggcc   2280

aaagagaatg gcatggatgt cttccgtgtg tttgactccc tcaactactt gcccaacatg   2340

ctgctgggca tggaggcggc aggaagtgcc ggaggcgtgg tggaggctgc catctcatac   2400

acgggcgacg tggccgaccc cagccgcacc aagtactcac tgcagtacta catgggcttg   2460

gccgaagagc tggtgcgagc tggcacccac atcctgtgca tcaaggacat ggccgggctg   2520

ctgaagccca cggcctgcac catgctggtc agctccctcc gggaccgctt ccccgacctc   2580

ccactgcaca tccacaccca cgacacgtca ggggcaggcg tggcagccat gctggcctgt   2640

gcccaggctg gagctgatgt ggtggatgtg gcagctgatt ccatgtctgg gatgacttca   2700

cagcccagca tgggggccct ggtggcctgt accagaggga ctcccctgga cacagaggtg   2760

cccatggagc gcgtgtttga ctacagtgag tactgggagg gggctcgggg actgtacgcg   2820

gccttcgact gcacggccac catgaagtct ggcaactcgg acgtgtatga aaatgagatc   2880

ccagggggcc agtacaccaa cctgcacttc caggcccaca gcatggggct tggctccaag   2940

ttcaaggagg tcaagaaggc ctatgtggag gccaaccaga tgctgggcga tctcatcaag   3000

gtgacgccct cctccaagat cgtgggggac ctggcccagt ttatggtgca gaatggattg   3060

agccgggcag aggccgaagc tcaggcggaa gagctgtcct ttccccgctc cgtggtggag   3120

ttcctgcagg gctacatcgg tgtcccccat ggggggttcc ccgaaccctt tcgctctaag   3180

gtactgaagg acctgccaag ggtggagggg cggcctggag cctccctccc tcccctggat   3240

ctgcaggcac tggagaagga gctggtagac cggcatgggg aggaggtgac gccggaagat   3300

gtgctctcag cagctatgta ccccgatgtg tttgcccact tcaaggactt cactgccacc   3360

tttggccccc tggatagcct gaatactcgc ctcttcctgc agggacccaa gatcgcagag   3420

gagtttgagg tggagctgga gcggggcaag acgctgcaca tcaaagccct ggccgtgagc   3480

gacctgaacc gggccggcca gaggcaggtc ttctttgagc tcaatgggca gctgcggtcc   3540

atcttggtca aggacaccca ggccatgaag gagatgcact tccaccccaa ggccctaaag   3600

gacgtgaagg gccagatcgg ggcgcccatg cctgggaagg tgatagacat caaagtggtg   3660

gcaggggcca aggtggccaa gggccagccc ctgtgtgtgc tcagtgccat gaagatggag   3720

actgtggtga cctcacccat ggagggtact gtccgcaagg ttcatgtgac caaggacatg   3780

acactggaag gtgacgacct catcctggag atcgagtgat cttgccccag accggcagcc   3840

tggccatccc caagccttca acagaagctg tgctgccacg gcaggcccag gccagccagt   3900

gcccgaggcc aggaaggccg ggccgtggag gtcctgtcca cagctggaca ggagagacac   3960

cgcctgcggt ggttcattcc tttcagccat cgtcctttcc tccggcggac agctgcttac   4020

atgttcatct cttgccaaat aagggtcccc tcctcactgg agactacaag tggtgggtca   4080

ggtggtccta ggacccaggg gaggtttagg ggtcctatct cctgggggaa ggggagatct   4140

aagatgtccc aggtcctggg aagtttactc aataaagctg gctttcccct gc           4192


<210>  2743
<211>  1178
<212>  PRT
<213>  Homosapiens

<400>  2743

Met Leu Lys Phe Arg Thr Val His Gly Gly Leu Arg Leu Leu Gly Ile 
1               5                   10                  15      


Arg Arg Thr Ser Thr Ala Pro Ala Ala Ser Pro Asn Val Arg Arg Leu 
            20                  25                  30          


Glu Tyr Lys Pro Ile Lys Lys Val Met Val Ala Asn Arg Gly Glu Ile 
        35                  40                  45              


Ala Ile Arg Val Phe Arg Ala Cys Thr Glu Leu Gly Ile Arg Thr Val 
    50                  55                  60                  


Ala Ile Tyr Ser Glu Gln Asp Thr Gly Gln Met His Arg Gln Lys Ala 
65                  70                  75                  80  


Asp Glu Ala Tyr Leu Ile Gly Arg Gly Leu Ala Pro Val Gln Ala Tyr 
                85                  90                  95      


Leu His Ile Pro Asp Ile Ile Lys Val Ala Lys Glu Asn Asn Val Asp 
            100                 105                 110         


Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Arg Ala Asp Phe Ala 
        115                 120                 125             


Gln Ala Cys Gln Asp Ala Gly Val Arg Phe Ile Gly Pro Ser Pro Glu 
    130                 135                 140                 


Val Val Arg Lys Met Gly Asp Lys Val Glu Ala Arg Ala Ile Ala Ile 
145                 150                 155                 160 


Ala Ala Gly Val Pro Val Val Pro Gly Thr Asp Ala Pro Ile Thr Ser 
                165                 170                 175     


Leu His Glu Ala His Glu Phe Ser Asn Thr Tyr Gly Phe Pro Ile Ile 
            180                 185                 190         


Phe Lys Ala Ala Tyr Gly Gly Gly Gly Arg Gly Met Arg Val Val His 
        195                 200                 205             


Ser Tyr Glu Glu Leu Glu Glu Asn Tyr Thr Arg Ala Tyr Ser Glu Ala 
    210                 215                 220                 


Leu Ala Ala Phe Gly Asn Gly Ala Leu Phe Val Glu Lys Phe Ile Glu 
225                 230                 235                 240 


Lys Pro Arg His Ile Glu Val Gln Ile Leu Gly Asp Gln Tyr Gly Asn 
                245                 250                 255     


Ile Leu His Leu Tyr Glu Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
            260                 265                 270         


Lys Val Val Glu Ile Ala Pro Ala Ala His Leu Asp Pro Gln Leu Arg 
        275                 280                 285             


Thr Arg Leu Thr Ser Asp Ser Val Lys Leu Ala Lys Gln Val Gly Tyr 
    290                 295                 300                 


Glu Asn Ala Gly Thr Val Glu Phe Leu Val Asp Arg His Gly Lys His 
305                 310                 315                 320 


Tyr Phe Ile Glu Val Asn Ser Arg Leu Gln Val Glu His Thr Val Thr 
                325                 330                 335     


Glu Glu Ile Thr Asp Val Asp Leu Val His Ala Gln Ile His Val Ala 
            340                 345                 350         


Glu Gly Arg Ser Leu Pro Asp Leu Gly Leu Arg Gln Glu Asn Ile Arg 
        355                 360                 365             


Ile Asn Gly Cys Ala Ile Gln Cys Arg Val Thr Thr Glu Asp Pro Ala 
    370                 375                 380                 


Arg Ser Phe Gln Pro Asp Thr Gly Arg Ile Glu Val Phe Arg Ser Gly 
385                 390                 395                 400 


Glu Gly Met Gly Ile Arg Leu Asp Asn Ala Ser Ala Phe Gln Gly Ala 
                405                 410                 415     


Val Ile Ser Pro His Tyr Asp Ser Leu Leu Val Lys Val Ile Ala His 
            420                 425                 430         


Gly Lys Asp His Pro Thr Ala Ala Thr Lys Met Ser Arg Ala Leu Ala 
        435                 440                 445             


Glu Phe Arg Val Arg Gly Val Lys Thr Asn Ile Ala Phe Leu Gln Asn 
    450                 455                 460                 


Val Leu Asn Asn Gln Gln Phe Leu Ala Gly Thr Val Asp Thr Gln Phe 
465                 470                 475                 480 


Ile Asp Glu Asn Pro Glu Leu Phe Gln Leu Arg Pro Ala Gln Asn Arg 
                485                 490                 495     


Ala Gln Lys Leu Leu His Tyr Leu Gly His Val Met Val Asn Gly Pro 
            500                 505                 510         


Thr Thr Pro Ile Pro Val Lys Ala Ser Pro Ser Pro Thr Asp Pro Val 
        515                 520                 525             


Val Pro Ala Val Pro Ile Gly Pro Pro Pro Ala Gly Phe Arg Asp Ile 
    530                 535                 540                 


Leu Leu Arg Glu Gly Pro Glu Gly Phe Ala Arg Ala Val Arg Asn His 
545                 550                 555                 560 


Pro Gly Leu Leu Leu Met Asp Thr Thr Phe Arg Asp Ala His Gln Ser 
                565                 570                 575     


Leu Leu Ala Thr Arg Val Arg Thr His Asp Leu Lys Lys Ile Ala Pro 
            580                 585                 590         


Tyr Val Ala His Asn Phe Ser Lys Leu Phe Ser Met Glu Asn Trp Gly 
        595                 600                 605             


Gly Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Cys Pro Trp 
    610                 615                 620                 


Arg Arg Leu Gln Glu Leu Arg Glu Leu Ile Pro Asn Ile Pro Phe Gln 
625                 630                 635                 640 


Met Leu Leu Arg Gly Ala Asn Ala Val Gly Tyr Thr Asn Tyr Pro Asp 
                645                 650                 655     


Asn Val Val Phe Lys Phe Cys Glu Val Ala Lys Glu Asn Gly Met Asp 
            660                 665                 670         


Val Phe Arg Val Phe Asp Ser Leu Asn Tyr Leu Pro Asn Met Leu Leu 
        675                 680                 685             


Gly Met Glu Ala Ala Gly Ser Ala Gly Gly Val Val Glu Ala Ala Ile 
    690                 695                 700                 


Ser Tyr Thr Gly Asp Val Ala Asp Pro Ser Arg Thr Lys Tyr Ser Leu 
705                 710                 715                 720 


Gln Tyr Tyr Met Gly Leu Ala Glu Glu Leu Val Arg Ala Gly Thr His 
                725                 730                 735     


Ile Leu Cys Ile Lys Asp Met Ala Gly Leu Leu Lys Pro Thr Ala Cys 
            740                 745                 750         


Thr Met Leu Val Ser Ser Leu Arg Asp Arg Phe Pro Asp Leu Pro Leu 
        755                 760                 765             


His Ile His Thr His Asp Thr Ser Gly Ala Gly Val Ala Ala Met Leu 
    770                 775                 780                 


Ala Cys Ala Gln Ala Gly Ala Asp Val Val Asp Val Ala Ala Asp Ser 
785                 790                 795                 800 


Met Ser Gly Met Thr Ser Gln Pro Ser Met Gly Ala Leu Val Ala Cys 
                805                 810                 815     


Thr Arg Gly Thr Pro Leu Asp Thr Glu Val Pro Met Glu Arg Val Phe 
            820                 825                 830         


Asp Tyr Ser Glu Tyr Trp Glu Gly Ala Arg Gly Leu Tyr Ala Ala Phe 
        835                 840                 845             


Asp Cys Thr Ala Thr Met Lys Ser Gly Asn Ser Asp Val Tyr Glu Asn 
    850                 855                 860                 


Glu Ile Pro Gly Gly Gln Tyr Thr Asn Leu His Phe Gln Ala His Ser 
865                 870                 875                 880 


Met Gly Leu Gly Ser Lys Phe Lys Glu Val Lys Lys Ala Tyr Val Glu 
                885                 890                 895     


Ala Asn Gln Met Leu Gly Asp Leu Ile Lys Val Thr Pro Ser Ser Lys 
            900                 905                 910         


Ile Val Gly Asp Leu Ala Gln Phe Met Val Gln Asn Gly Leu Ser Arg 
        915                 920                 925             


Ala Glu Ala Glu Ala Gln Ala Glu Glu Leu Ser Phe Pro Arg Ser Val 
    930                 935                 940                 


Val Glu Phe Leu Gln Gly Tyr Ile Gly Val Pro His Gly Gly Phe Pro 
945                 950                 955                 960 


Glu Pro Phe Arg Ser Lys Val Leu Lys Asp Leu Pro Arg Val Glu Gly 
                965                 970                 975     


Arg Pro Gly Ala Ser Leu Pro Pro Leu Asp Leu Gln Ala Leu Glu Lys 
            980                 985                 990         


Glu Leu Val Asp Arg His Gly Glu  Glu Val Thr Pro Glu  Asp Val Leu 
        995                 1000                 1005             


Ser Ala  Ala Met Tyr Pro Asp  Val Phe Ala His Phe  Lys Asp Phe 
    1010                 1015                 1020             


Thr Ala  Thr Phe Gly Pro Leu  Asp Ser Leu Asn Thr  Arg Leu Phe 
    1025                 1030                 1035             


Leu Gln  Gly Pro Lys Ile Ala  Glu Glu Phe Glu Val  Glu Leu Glu 
    1040                 1045                 1050             


Arg Gly  Lys Thr Leu His Ile  Lys Ala Leu Ala Val  Ser Asp Leu 
    1055                 1060                 1065             


Asn Arg  Ala Gly Gln Arg Gln  Val Phe Phe Glu Leu  Asn Gly Gln 
    1070                 1075                 1080             


Leu Arg  Ser Ile Leu Val Lys  Asp Thr Gln Ala Met  Lys Glu Met 
    1085                 1090                 1095             


His Phe  His Pro Lys Ala Leu  Lys Asp Val Lys Gly  Gln Ile Gly 
    1100                 1105                 1110             


Ala Pro  Met Pro Gly Lys Val  Ile Asp Ile Lys Val  Val Ala Gly 
    1115                 1120                 1125             


Ala Lys  Val Ala Lys Gly Gln  Pro Leu Cys Val Leu  Ser Ala Met 
    1130                 1135                 1140             


Lys Met  Glu Thr Val Val Thr  Ser Pro Met Glu Gly  Thr Val Arg 
    1145                 1150                 1155             


Lys Val  His Val Thr Lys Asp  Met Thr Leu Glu Gly  Asp Asp Leu 
    1160                 1165                 1170             


Ile Leu  Glu Ile Glu 
    1175             


<210>  2744
<211>  3959
<212>  DNA
<213>  Homosapiens

<400>  2744
ttacaggaac agtgtggcct ctctggaact ctgcagacca actgccgtga tgctgaagtt     60

ccgaacagtc catgggggcc tgaggctcct gggaatccgc cgaacctcca ccgcccccgc    120

tgcctcccca aatgtccggc gcctggagta taagcccatc aagaaagtca tggtggccaa    180

cagaggtgag attgccatcc gtgtgttccg ggcctgcacg gagctgggca tccgcaccgt    240

agccatctac tctgagcagg acacgggcca gatgcaccgg cagaaagcag atgaagccta    300

tctcatcggc cgcggcctgg cccccgtgca ggcctacctg cacatcccag acatcatcaa    360

ggtggccaag gagaacaacg tagatgcagt gcaccctggc tacgggttcc tctctgagcg    420

agcggacttc gcccaggcct gccaggatgc aggggtccgg tttattgggc caagcccaga    480

agtggtccgc aagatgggag acaaggtgga ggcccgggcc atcgccattg ctgcgggtgt    540

tcccgttgtc cctggcacag atgcccccat cacgtccctg catgaggccc acgagttctc    600

caacacctac ggcttcccca tcatcttcaa ggcggcctat gggggtggag ggcgtggcat    660

gagggtggtg cacagctacg aggagctgga ggagaattac acccgggcct actcagaggc    720

tctggccgcc tttgggaatg gggcgctgtt tgtggagaag ttcatcgaga agccacggca    780

catcgaggtg cagatcttgg gggaccagta tgggaacatc ctgcacctgt acgagcgaga    840

ctgctccatc cagcggcggc accagaaggt ggtcgagatt gcccccgccg cccacctgga    900

cccgcagctt cggactcggc tcaccagcga ctctgtgaaa ctcgctaaac aggtgggcta    960

cgagaacgca ggcaccgtgg agttcctggt ggacaggcac ggcaagcact acttcatcga   1020

ggtcaactcc cgcctgcagg tggagcacac ggtcacagag gagatcaccg acgtagacct   1080

ggtccatgct cagatccacg tggctgaggg caggagccta cccgacctgg gcctgcggca   1140

ggagaacatc cgcatcaacg ggtgtgccat ccagtgccgg gtcaccaccg aggaccccgc   1200

gcgcagcttc cagccggaca ccggccgcat tgaggtgttc cggagcggag agggcatggg   1260

catccgcctg gataatgctt ccgccttcca aggagccgtc atctcgcccc actacgactc   1320

cctgctggtc aaagtcattg cccacggcaa agaccacccc acggccgcca ccaagatgag   1380

cagggccctt gcggagttcc gcgtccgagg tgtgaagacc aacatcgcct tcctgcagaa   1440

tgtgctcaac aaccagcagt tcctggcagg cactgtggac acccagttca tcgacgagaa   1500

cccagagctg ttccagctgc ggcctgcaca gaaccgggcc caaaagctgt tgcactacct   1560

cggccatgtc atggtaaacg gtccaaccac cccgattccc gtcaaggcca gccccagccc   1620

cacggacccc gttgtccctg cagtgcccat aggcccgccc ccggctggtt tcagagacat   1680

cctgctgcga gaggggcctg agggctttgc tcgagctgtg cggaaccacc cggggctgct   1740

gctgatggac acgaccttca gggacgccca ccagtcactg ctggccactc gtgtgcgcac   1800

ccacgatctc aaaaagatcg ccccctatgt tgcccacaac ttcagcaagc tcttcagcat   1860

ggagaactgg ggaggagcca cgtttgacgt cgccatgcgc ttcctgtatg agtgcccctg   1920

gcggcggctg caggagctcc gggagctcat ccccaacatc cctttccaga tgctgctgcg   1980

gggggccaat gctgtgggct acaccaacta cccagacaac gtggtcttca agttctgtga   2040

agtggccaaa gagaatggca tggatgtctt ccgtgtgttt gactccctca actacttgcc   2100

caacatgctg ctgggcatgg aggcggcagg aagtgccgga ggcgtggtgg aggctgccat   2160

ctcatacacg ggcgacgtgg ccgaccccag ccgcaccaag tactcactgc agtactacat   2220

gggcttggcc gaagagctgg tgcgagctgg cacccacatc ctgtgcatca aggacatggc   2280

cgggctgctg aagcccacgg cctgcaccat gctggtcagc tccctccggg accgcttccc   2340

cgacctccca ctgcacatcc acacccacga cacgtcaggg gcaggcgtgg cagccatgct   2400

ggcctgtgcc caggctggag ctgatgtggt ggatgtggca gctgattcca tgtctgggat   2460

gacttcacag cccagcatgg gggccctggt ggcctgtacc agagggactc ccctggacac   2520

agaggtgccc atggagcgcg tgtttgacta cagtgagtac tgggaggggg ctcggggact   2580

gtacgcggcc ttcgactgca cggccaccat gaagtctggc aactcggacg tgtatgaaaa   2640

tgagatccca gggggccagt acaccaacct gcacttccag gcccacagca tggggcttgg   2700

ctccaagttc aaggaggtca agaaggccta tgtggaggcc aaccagatgc tgggcgatct   2760

catcaaggtg acgccctcct ccaagatcgt gggggacctg gcccagttta tggtgcagaa   2820

tggattgagc cgggcagagg ccgaagctca ggcggaagag ctgtcctttc cccgctccgt   2880

ggtggagttc ctgcagggct acatcggtgt cccccatggg gggttccccg aaccctttcg   2940

ctctaaggta ctgaaggacc tgccaagggt ggaggggcgg cctggagcct ccctccctcc   3000

cctggatctg caggcactgg agaaggagct ggtagaccgg catggggagg aggtgacgcc   3060

ggaagatgtg ctctcagcag ctatgtaccc cgatgtgttt gcccacttca aggacttcac   3120

tgccaccttt ggccccctgg atagcctgaa tactcgcctc ttcctgcagg gacccaagat   3180

cgcagaggag tttgaggtgg agctggagcg gggcaagacg ctgcacatca aagccctggc   3240

cgtgagcgac ctgaaccggg ccggccagag gcaggtcttc tttgagctca atgggcagct   3300

gcggtccatc ttggtcaagg acacccaggc catgaaggag atgcacttcc accccaaggc   3360

cctaaaggac gtgaagggcc agatcggggc gcccatgcct gggaaggtga tagacatcaa   3420

agtggtggca ggggccaagg tggccaaggg ccagcccctg tgtgtgctca gtgccatgaa   3480

gatggagact gtggtgacct cacccatgga gggtactgtc cgcaaggttc atgtgaccaa   3540

ggacatgaca ctggaaggtg acgacctcat cctggagatc gagtgatctt gccccagacc   3600

ggcagcctgg ccatccccaa gccttcaaca gaagctgtgc tgccacggca ggcccaggcc   3660

agccagtgcc cgaggccagg aaggccgggc cgtggaggtc ctgtccacag ctggacagga   3720

gagacaccgc ctgcggtggt tcattccttt cagccatcgt cctttcctcc ggcggacagc   3780

tgcttacatg ttcatctctt gccaaataag ggtcccctcc tcactggaga ctacaagtgg   3840

tgggtcaggt ggtcctagga cccaggggag gtttaggggt cctatctcct gggggaaggg   3900

gagatctaag atgtcccagg tcctgggaag tttactcaat aaagctggct ttcccctgc    3959


<210>  2745
<211>  1178
<212>  PRT
<213>  Homosapiens

<400>  2745

Met Leu Lys Phe Arg Thr Val His Gly Gly Leu Arg Leu Leu Gly Ile 
1               5                   10                  15      


Arg Arg Thr Ser Thr Ala Pro Ala Ala Ser Pro Asn Val Arg Arg Leu 
            20                  25                  30          


Glu Tyr Lys Pro Ile Lys Lys Val Met Val Ala Asn Arg Gly Glu Ile 
        35                  40                  45              


Ala Ile Arg Val Phe Arg Ala Cys Thr Glu Leu Gly Ile Arg Thr Val 
    50                  55                  60                  


Ala Ile Tyr Ser Glu Gln Asp Thr Gly Gln Met His Arg Gln Lys Ala 
65                  70                  75                  80  


Asp Glu Ala Tyr Leu Ile Gly Arg Gly Leu Ala Pro Val Gln Ala Tyr 
                85                  90                  95      


Leu His Ile Pro Asp Ile Ile Lys Val Ala Lys Glu Asn Asn Val Asp 
            100                 105                 110         


Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Arg Ala Asp Phe Ala 
        115                 120                 125             


Gln Ala Cys Gln Asp Ala Gly Val Arg Phe Ile Gly Pro Ser Pro Glu 
    130                 135                 140                 


Val Val Arg Lys Met Gly Asp Lys Val Glu Ala Arg Ala Ile Ala Ile 
145                 150                 155                 160 


Ala Ala Gly Val Pro Val Val Pro Gly Thr Asp Ala Pro Ile Thr Ser 
                165                 170                 175     


Leu His Glu Ala His Glu Phe Ser Asn Thr Tyr Gly Phe Pro Ile Ile 
            180                 185                 190         


Phe Lys Ala Ala Tyr Gly Gly Gly Gly Arg Gly Met Arg Val Val His 
        195                 200                 205             


Ser Tyr Glu Glu Leu Glu Glu Asn Tyr Thr Arg Ala Tyr Ser Glu Ala 
    210                 215                 220                 


Leu Ala Ala Phe Gly Asn Gly Ala Leu Phe Val Glu Lys Phe Ile Glu 
225                 230                 235                 240 


Lys Pro Arg His Ile Glu Val Gln Ile Leu Gly Asp Gln Tyr Gly Asn 
                245                 250                 255     


Ile Leu His Leu Tyr Glu Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
            260                 265                 270         


Lys Val Val Glu Ile Ala Pro Ala Ala His Leu Asp Pro Gln Leu Arg 
        275                 280                 285             


Thr Arg Leu Thr Ser Asp Ser Val Lys Leu Ala Lys Gln Val Gly Tyr 
    290                 295                 300                 


Glu Asn Ala Gly Thr Val Glu Phe Leu Val Asp Arg His Gly Lys His 
305                 310                 315                 320 


Tyr Phe Ile Glu Val Asn Ser Arg Leu Gln Val Glu His Thr Val Thr 
                325                 330                 335     


Glu Glu Ile Thr Asp Val Asp Leu Val His Ala Gln Ile His Val Ala 
            340                 345                 350         


Glu Gly Arg Ser Leu Pro Asp Leu Gly Leu Arg Gln Glu Asn Ile Arg 
        355                 360                 365             


Ile Asn Gly Cys Ala Ile Gln Cys Arg Val Thr Thr Glu Asp Pro Ala 
    370                 375                 380                 


Arg Ser Phe Gln Pro Asp Thr Gly Arg Ile Glu Val Phe Arg Ser Gly 
385                 390                 395                 400 


Glu Gly Met Gly Ile Arg Leu Asp Asn Ala Ser Ala Phe Gln Gly Ala 
                405                 410                 415     


Val Ile Ser Pro His Tyr Asp Ser Leu Leu Val Lys Val Ile Ala His 
            420                 425                 430         


Gly Lys Asp His Pro Thr Ala Ala Thr Lys Met Ser Arg Ala Leu Ala 
        435                 440                 445             


Glu Phe Arg Val Arg Gly Val Lys Thr Asn Ile Ala Phe Leu Gln Asn 
    450                 455                 460                 


Val Leu Asn Asn Gln Gln Phe Leu Ala Gly Thr Val Asp Thr Gln Phe 
465                 470                 475                 480 


Ile Asp Glu Asn Pro Glu Leu Phe Gln Leu Arg Pro Ala Gln Asn Arg 
                485                 490                 495     


Ala Gln Lys Leu Leu His Tyr Leu Gly His Val Met Val Asn Gly Pro 
            500                 505                 510         


Thr Thr Pro Ile Pro Val Lys Ala Ser Pro Ser Pro Thr Asp Pro Val 
        515                 520                 525             


Val Pro Ala Val Pro Ile Gly Pro Pro Pro Ala Gly Phe Arg Asp Ile 
    530                 535                 540                 


Leu Leu Arg Glu Gly Pro Glu Gly Phe Ala Arg Ala Val Arg Asn His 
545                 550                 555                 560 


Pro Gly Leu Leu Leu Met Asp Thr Thr Phe Arg Asp Ala His Gln Ser 
                565                 570                 575     


Leu Leu Ala Thr Arg Val Arg Thr His Asp Leu Lys Lys Ile Ala Pro 
            580                 585                 590         


Tyr Val Ala His Asn Phe Ser Lys Leu Phe Ser Met Glu Asn Trp Gly 
        595                 600                 605             


Gly Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Cys Pro Trp 
    610                 615                 620                 


Arg Arg Leu Gln Glu Leu Arg Glu Leu Ile Pro Asn Ile Pro Phe Gln 
625                 630                 635                 640 


Met Leu Leu Arg Gly Ala Asn Ala Val Gly Tyr Thr Asn Tyr Pro Asp 
                645                 650                 655     


Asn Val Val Phe Lys Phe Cys Glu Val Ala Lys Glu Asn Gly Met Asp 
            660                 665                 670         


Val Phe Arg Val Phe Asp Ser Leu Asn Tyr Leu Pro Asn Met Leu Leu 
        675                 680                 685             


Gly Met Glu Ala Ala Gly Ser Ala Gly Gly Val Val Glu Ala Ala Ile 
    690                 695                 700                 


Ser Tyr Thr Gly Asp Val Ala Asp Pro Ser Arg Thr Lys Tyr Ser Leu 
705                 710                 715                 720 


Gln Tyr Tyr Met Gly Leu Ala Glu Glu Leu Val Arg Ala Gly Thr His 
                725                 730                 735     


Ile Leu Cys Ile Lys Asp Met Ala Gly Leu Leu Lys Pro Thr Ala Cys 
            740                 745                 750         


Thr Met Leu Val Ser Ser Leu Arg Asp Arg Phe Pro Asp Leu Pro Leu 
        755                 760                 765             


His Ile His Thr His Asp Thr Ser Gly Ala Gly Val Ala Ala Met Leu 
    770                 775                 780                 


Ala Cys Ala Gln Ala Gly Ala Asp Val Val Asp Val Ala Ala Asp Ser 
785                 790                 795                 800 


Met Ser Gly Met Thr Ser Gln Pro Ser Met Gly Ala Leu Val Ala Cys 
                805                 810                 815     


Thr Arg Gly Thr Pro Leu Asp Thr Glu Val Pro Met Glu Arg Val Phe 
            820                 825                 830         


Asp Tyr Ser Glu Tyr Trp Glu Gly Ala Arg Gly Leu Tyr Ala Ala Phe 
        835                 840                 845             


Asp Cys Thr Ala Thr Met Lys Ser Gly Asn Ser Asp Val Tyr Glu Asn 
    850                 855                 860                 


Glu Ile Pro Gly Gly Gln Tyr Thr Asn Leu His Phe Gln Ala His Ser 
865                 870                 875                 880 


Met Gly Leu Gly Ser Lys Phe Lys Glu Val Lys Lys Ala Tyr Val Glu 
                885                 890                 895     


Ala Asn Gln Met Leu Gly Asp Leu Ile Lys Val Thr Pro Ser Ser Lys 
            900                 905                 910         


Ile Val Gly Asp Leu Ala Gln Phe Met Val Gln Asn Gly Leu Ser Arg 
        915                 920                 925             


Ala Glu Ala Glu Ala Gln Ala Glu Glu Leu Ser Phe Pro Arg Ser Val 
    930                 935                 940                 


Val Glu Phe Leu Gln Gly Tyr Ile Gly Val Pro His Gly Gly Phe Pro 
945                 950                 955                 960 


Glu Pro Phe Arg Ser Lys Val Leu Lys Asp Leu Pro Arg Val Glu Gly 
                965                 970                 975     


Arg Pro Gly Ala Ser Leu Pro Pro Leu Asp Leu Gln Ala Leu Glu Lys 
            980                 985                 990         


Glu Leu Val Asp Arg His Gly Glu  Glu Val Thr Pro Glu  Asp Val Leu 
        995                 1000                 1005             


Ser Ala  Ala Met Tyr Pro Asp  Val Phe Ala His Phe  Lys Asp Phe 
    1010                 1015                 1020             


Thr Ala  Thr Phe Gly Pro Leu  Asp Ser Leu Asn Thr  Arg Leu Phe 
    1025                 1030                 1035             


Leu Gln  Gly Pro Lys Ile Ala  Glu Glu Phe Glu Val  Glu Leu Glu 
    1040                 1045                 1050             


Arg Gly  Lys Thr Leu His Ile  Lys Ala Leu Ala Val  Ser Asp Leu 
    1055                 1060                 1065             


Asn Arg  Ala Gly Gln Arg Gln  Val Phe Phe Glu Leu  Asn Gly Gln 
    1070                 1075                 1080             


Leu Arg  Ser Ile Leu Val Lys  Asp Thr Gln Ala Met  Lys Glu Met 
    1085                 1090                 1095             


His Phe  His Pro Lys Ala Leu  Lys Asp Val Lys Gly  Gln Ile Gly 
    1100                 1105                 1110             


Ala Pro  Met Pro Gly Lys Val  Ile Asp Ile Lys Val  Val Ala Gly 
    1115                 1120                 1125             


Ala Lys  Val Ala Lys Gly Gln  Pro Leu Cys Val Leu  Ser Ala Met 
    1130                 1135                 1140             


Lys Met  Glu Thr Val Val Thr  Ser Pro Met Glu Gly  Thr Val Arg 
    1145                 1150                 1155             


Lys Val  His Val Thr Lys Asp  Met Thr Leu Glu Gly  Asp Asp Leu 
    1160                 1165                 1170             


Ile Leu  Glu Ile Glu 
    1175             


<210>  2746
<211>  2449
<212>  DNA
<213>  Homosapiens

<400>  2746
cttgtcccca gcgcctggac tcccccttaa ctgcttggga aatgtgacct ttgctctggg     60

gggcctggcc ctgcaggccc caaccttccc tcatctctgg cggccctctt gggcctctga    120

cccagcccct ccccgggcca ggctcacaga agctggcttc tgggactgtc ctgggcccaa    180

gtgggcacct gcgccagccc cacctgtgcc tgggctgtgg ccccttccta cagggcgctc    240

accatggccc cgccgctcct gctgctgctg ctggccagtg gagcggccgc ctgcccgctg    300

ccctgcgtct gccagaacct gtccgagtcg ctcagcaccc tctgtgccca ccgaggcctg    360

ctgtttgtgc cgcccaacgt ggaccggcgc acagtggagc tgcggctggc tgacaacttc    420

atccaggccc tggggccccc tgacttccgc aacatgacgg gactggtgga cctgacactg    480

tctcgcaatg ccatcacccg cattggggcc cgcgcctttg gggacctcga gagcctgcgt    540

tccctccacc ttgacggcaa caggctggtg gagctgggca ccgggagcct ccggggcccc    600

gtcaatctgc agcacctcat cctcagcggc aaccagctgg gccgcatcgc gccgggagcc    660

ttcgacgact tcctagagag cctggaggac ctggacctgt cctacaacaa cctccggcag    720

gtgccctggg ccggcatcgg cgccatgcct gccctgcaca ccctcaacct ggaccataac    780

cttattgacg cactgccccc aggcgccttc gcccagctcg gtcagctctc ccgcctggac    840

ctcacctcca accgcctggc cacgctggct ccggacccgc ttttctctcg tgggcgtgat    900

gcagaggcct ctcccgcccc cctggtgctg agctttagcg ggaaccccct gcactgcaac    960

tgtgagctgc tgtggctgcg gcggctggcg cggccggacg acctggaaac gtgcgcctcc   1020

ccgcccggcc tggccggccg ctacttctgg gcagtgcccg agggcgagtt ctcctgtgag   1080

ccgcccctca ttgcccgcca cacgcagcgc ctctgggtgc tggaaggcca gcgggccacg   1140

ctgcggtgcc gggccctggg tgaccccgcg cctaccatgc actgggtcgg tcctgacgac   1200

cggttggttg gcaactcctc ccgagcccgg gctttcccca acgggacctt agagattggg   1260

gtgaccggcg ctggggacgc tgggggctac acctgcatcg ccaccaaccc tgctggtgag   1320

gccacagccc gagtagaact gcgggtgctg gccttgcccc atggtgggaa cagcagtgcc   1380

gaggggggcc gccccgggcc ctcggacatc gccgcctccg ctcgcactgc tgccgagggt   1440

gaggggacgc tggagtctga gccagccgtg caggtgacgg aggtgaccgc cacctcaggg   1500

ctggtgagct ggggtcccgg gcggccagcc gacccagtgt ggatgttcca aatccagtac   1560

aacagcagcg aagatgagac cctcatctac cggattgtcc cagcctccag ccaccacttc   1620

ctgctgaagc acctcgtccc cggcgctgac tatgacctct gcctgctggc cttgtcaccg   1680

gccgctgggc cctctgacct cacggccacc aggctgctgg gctgtgccca tttctccacg   1740

ctgccggcct cgcccctgtg ccacgccctg caggcccacg tgctgggcgg gaccctgacc   1800

gtggccgtgg ggggtgtgct ggtggctgcc ttactggtct tcactgtggc cttgctggtt   1860

cggggccggg gggccggaaa tggccgcctc cccctcaagc tcagccacgt ccagtcccag   1920

accaatggag gccccagccc cacacccaag gcccacccgc cgcggagccc cccgccccgg   1980

ccgcagcgca gctgctctct ggacctggga gatgccgggt gctacggtta tgccaggcgc   2040

ctgggaggag cttgggcccg acggagccac tctgtgcatg gggggctgct cggggcaggg   2100

tgccgggggg taggaggcag cgccgagcgg ctggaagaga gtgtggtgtg atggacgggc   2160

agcttcctgt gtgctccaag ggatgagcct cgtggggcag agggcccggg gccgccgcct   2220

ggcctgggag tccctccctg gtttttattc tcagtacctc aggctcccct gtgtacttgg   2280

aggggcaggg agccctttcc tcggttctgg cctccagacc agggtaaggg caggcccctc   2340

caacaggtgc tcacagccac cgaggcaggg gctgcagcca cccactggga gtcttgtttt   2400

tatttataat aaaattgttg gggacacctc aaaaaaaaaa aaaaaaaaa               2449


<210>  2747
<211>  635
<212>  PRT
<213>  Homosapiens

<400>  2747

Met Ala Pro Pro Leu Leu Leu Leu Leu Leu Ala Ser Gly Ala Ala Ala 
1               5                   10                  15      


Cys Pro Leu Pro Cys Val Cys Gln Asn Leu Ser Glu Ser Leu Ser Thr 
            20                  25                  30          


Leu Cys Ala His Arg Gly Leu Leu Phe Val Pro Pro Asn Val Asp Arg 
        35                  40                  45              


Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Ile Gln Ala Leu Gly 
    50                  55                  60                  


Pro Pro Asp Phe Arg Asn Met Thr Gly Leu Val Asp Leu Thr Leu Ser 
65                  70                  75                  80  


Arg Asn Ala Ile Thr Arg Ile Gly Ala Arg Ala Phe Gly Asp Leu Glu 
                85                  90                  95      


Ser Leu Arg Ser Leu His Leu Asp Gly Asn Arg Leu Val Glu Leu Gly 
            100                 105                 110         


Thr Gly Ser Leu Arg Gly Pro Val Asn Leu Gln His Leu Ile Leu Ser 
        115                 120                 125             


Gly Asn Gln Leu Gly Arg Ile Ala Pro Gly Ala Phe Asp Asp Phe Leu 
    130                 135                 140                 


Glu Ser Leu Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Arg Gln Val 
145                 150                 155                 160 


Pro Trp Ala Gly Ile Gly Ala Met Pro Ala Leu His Thr Leu Asn Leu 
                165                 170                 175     


Asp His Asn Leu Ile Asp Ala Leu Pro Pro Gly Ala Phe Ala Gln Leu 
            180                 185                 190         


Gly Gln Leu Ser Arg Leu Asp Leu Thr Ser Asn Arg Leu Ala Thr Leu 
        195                 200                 205             


Ala Pro Asp Pro Leu Phe Ser Arg Gly Arg Asp Ala Glu Ala Ser Pro 
    210                 215                 220                 


Ala Pro Leu Val Leu Ser Phe Ser Gly Asn Pro Leu His Cys Asn Cys 
225                 230                 235                 240 


Glu Leu Leu Trp Leu Arg Arg Leu Ala Arg Pro Asp Asp Leu Glu Thr 
                245                 250                 255     


Cys Ala Ser Pro Pro Gly Leu Ala Gly Arg Tyr Phe Trp Ala Val Pro 
            260                 265                 270         


Glu Gly Glu Phe Ser Cys Glu Pro Pro Leu Ile Ala Arg His Thr Gln 
        275                 280                 285             


Arg Leu Trp Val Leu Glu Gly Gln Arg Ala Thr Leu Arg Cys Arg Ala 
    290                 295                 300                 


Leu Gly Asp Pro Ala Pro Thr Met His Trp Val Gly Pro Asp Asp Arg 
305                 310                 315                 320 


Leu Val Gly Asn Ser Ser Arg Ala Arg Ala Phe Pro Asn Gly Thr Leu 
                325                 330                 335     


Glu Ile Gly Val Thr Gly Ala Gly Asp Ala Gly Gly Tyr Thr Cys Ile 
            340                 345                 350         


Ala Thr Asn Pro Ala Gly Glu Ala Thr Ala Arg Val Glu Leu Arg Val 
        355                 360                 365             


Leu Ala Leu Pro His Gly Gly Asn Ser Ser Ala Glu Gly Gly Arg Pro 
    370                 375                 380                 


Gly Pro Ser Asp Ile Ala Ala Ser Ala Arg Thr Ala Ala Glu Gly Glu 
385                 390                 395                 400 


Gly Thr Leu Glu Ser Glu Pro Ala Val Gln Val Thr Glu Val Thr Ala 
                405                 410                 415     


Thr Ser Gly Leu Val Ser Trp Gly Pro Gly Arg Pro Ala Asp Pro Val 
            420                 425                 430         


Trp Met Phe Gln Ile Gln Tyr Asn Ser Ser Glu Asp Glu Thr Leu Ile 
        435                 440                 445             


Tyr Arg Ile Val Pro Ala Ser Ser His His Phe Leu Leu Lys His Leu 
    450                 455                 460                 


Val Pro Gly Ala Asp Tyr Asp Leu Cys Leu Leu Ala Leu Ser Pro Ala 
465                 470                 475                 480 


Ala Gly Pro Ser Asp Leu Thr Ala Thr Arg Leu Leu Gly Cys Ala His 
                485                 490                 495     


Phe Ser Thr Leu Pro Ala Ser Pro Leu Cys His Ala Leu Gln Ala His 
            500                 505                 510         


Val Leu Gly Gly Thr Leu Thr Val Ala Val Gly Gly Val Leu Val Ala 
        515                 520                 525             


Ala Leu Leu Val Phe Thr Val Ala Leu Leu Val Arg Gly Arg Gly Ala 
    530                 535                 540                 


Gly Asn Gly Arg Leu Pro Leu Lys Leu Ser His Val Gln Ser Gln Thr 
545                 550                 555                 560 


Asn Gly Gly Pro Ser Pro Thr Pro Lys Ala His Pro Pro Arg Ser Pro 
                565                 570                 575     


Pro Pro Arg Pro Gln Arg Ser Cys Ser Leu Asp Leu Gly Asp Ala Gly 
            580                 585                 590         


Cys Tyr Gly Tyr Ala Arg Arg Leu Gly Gly Ala Trp Ala Arg Arg Ser 
        595                 600                 605             


His Ser Val His Gly Gly Leu Leu Gly Ala Gly Cys Arg Gly Val Gly 
    610                 615                 620                 


Gly Ser Ala Glu Arg Leu Glu Glu Ser Val Val 
625                 630                 635 


<210>  2748
<211>  3520
<212>  DNA
<213>  Homosapiens

<400>  2748
ctggagccca gccggagcgg cggcccctcc gcggagcccg gtcacagtca ctgcagcaga     60

catcatggct gtggatgtgg cagaatacca tctgagcgtc atcaagagcc cccctggctg    120

ggaggtgggt gtctatgctg caggggccct ggccctgctg ggaatcgcag ctgtgagcct    180

gtggaagctc tggacgtcgg ggagcttccc cagcccctct ccgttcccca attacgacta    240

caggtacctt cagcagaagt acggcgagag ctgcgcagag gccagggaga agagagtgcc    300

tgcctggaat gcccagcggg ccagcacgcg gggaccaccc agccgcaaag gcagtctcag    360

cattgaggac acctttgaga gcatcagtga actggggcct ctggagctga tgggccggga    420

gttggacctg gccccctatg ggaccctccg gaagtcccag tcggccgact ccctgaactc    480

catctcctcc gtgagcaaca cctttgggca ggacttcaca ctgggccagg tggaggtgag    540

catggagtac gacactgcct cccacacgct gaacgtggcg gtgatgcagg gcaaggacct    600

cctggagcgg gaggaggcca gcttcgagtc ctgcttcatg cgcgtcagcc tgctgccgga    660

cgagcagatc gtgggcattt ctcggatcca gagaaatgcc tactccatct tctttgatga    720

gaagttctcc atccccctgg atcccacagc cctggaggag aagagcctgc ggttttctgt    780

atttggcatc gatgaggatg agcgcaacgt cagcacgggg gtggtggagc tgaagctttc    840

tgtgcttgac ctcccgctgc agcccttcag tggctggctc tatttacagg accagaacaa    900

ggccgccgat gctgtggggg agatcctgct ctccctcagc tacctcccca cagccgagcg    960

cctcaccgtg gtcgtggtta aggccaagaa cctcatctgg accaacgaca agaccacagc   1020

ggaccccttc gtcaaggtgt acctgctgca ggatgggagg aagatgagca aaaagaagac   1080

agccgtgaag agggatgacc ccaacccggt gttcaacgaa gccatgatct tctcggtgcc   1140

agccattgtg ctccaggacc tgtctctccg cgtgacggtg gctgagagca gcagcgacgg   1200

ccgtggggac aacgtgggcc atgtcatcat tgggccgtca gccagtggca tgggaaccac   1260

acattggaac cagatgttgg ccacgctgcg caggcccgtg tccatgtggc acgctgtccg   1320

gcgaaactag caaccagggc gggccagttg ggcaatggag ctgctggagc ccggtaccca   1380

ctcagctctg tctgatgccc tctccatagc ccagctggag ccgtgaacac tggggtcccc   1440

tggcagagtc ctcatgaccc atcctggtct ctctgtccag attgcagcag aggagtgggc   1500

gtggctctgt gtccagggcc ccagggtctg ctcctgctga ggaccagctg tggctgggcc   1560

aggacagagg actcaaccct gctcctcccg gtaggccagc tgccgagctg ggctatgttc   1620

tggaacccag tgaatcttgg gggccaggca ctgtgctagg caccagcagg ggtaacacga   1680

agaagacccg gcccttaggg catcaggaag actagctccc ctgccccgga ggatctgctc   1740

agtgctgatg gcagcccagc tgtgtggact cagggggctc tgagggctag ggaaacagga   1800

agggcctctt tgacaaggta ggagctgtgc ttggaggggc aggaaaagaa ctgagcatgt   1860

cgcaggcagc gggcccagcc tgagcaatgg caggatgtga acttccccat cgcaaatgca   1920

gttctcagcc cactgcagtg gatacaagga agggcctttc tcggggccgg agaagagacc   1980

aagagaccag gcccgggcag cagcctaccg gccacgtgga acactggctc cggagttatt   2040

ctctgtcaaa tctactcccc ggacctcaac catggcaaga accagaggtc caaagaggcc   2100

cagacccagg tccttgtgct cagtcctgcg caaaccaggc ccagaccctg caagcatttg   2160

ttgatgccct tgcaggccca ctgggagaaa gatgcctcag gcaggtctca gcctgggggt   2220

ggcaggggtg gggcagagag aatactgaca gcagaggtct tggtgggctg cacgtgcctg   2280

cgaagatgtg gtggacaagg aggctctcgg gctgggcctt ggaggggtgg cagcggaagg   2340

acagcccagg tggctgaggc ctgatgggaa gccggggaag gccagggtgg aagggcggct   2400

tgagggacgc caggagaaga ctgaatgcca ggctaggaag gaggcggctc tcgatcacgg   2460

ggtgggtgcc cccgacaccg ggtctcctag cttgagttcc ctagaagcga aatctgagag   2520

ggggattctg gggcaagtag tttcttgcgg gtgagtgttc tcagagaaac ttaccagatc   2580

aagaaaggga gctcaggctg gatggaggaa gccacgcaag tgtggcttca agatccatcg   2640

ccttggcctg atcgctgtgg gggcaggggc ctggagtacg aggggcaccc tgggggctcc   2700

cacccagaag cagaggggct gggctgttgc acctctactg gcatcagtct ttggttaccc   2760

cccagcccca gtaggaggag agcaggcaga gcttgtcatc cccagcctgg tgtcccgcag   2820

tcccaggaag ccgcttcttg ccttcatggc tgagtgctgg gaagggctga gctcacccag   2880

gccagcaggt ggggtatcat ctgctcggtg gggccaccca caggtgacag catggaccct   2940

caggctggct gcccctgttc cttggtccat aactggtgag ctatggagac ccaggccaac   3000

aaattatccc cagtgatatg gggggaggag gggctagaac aagggcccag gggactggag   3060

gcaggatggt ggctttccct acctgacaca gccatggccc agccccaagg ccaggctgtc   3120

taccctatgg ccacagcagg aggtcagccc agggccagga gacacatggc tggacaaggc   3180

tttgcagcct gggagacccc gactttctct aacccagtgg ctgtgcggtg caggccactg   3240

actccccccc tgccctctcc cctctctccc tccccctaac tgcatgacat gttaactgtg   3300

tgcccaggac agccgtggtg gggaccgggt atgccaactg gaatgattct agaaccaaaa   3360

taaagttggg gcaggaagag ggggcttcca gggagccctg ctcggccctg aatcaccttc   3420

gtctcttctc taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3480

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                         3520


<210>  2749
<211>  421
<212>  PRT
<213>  Homosapiens

<400>  2749

Met Ala Val Asp Val Ala Glu Tyr His Leu Ser Val Ile Lys Ser Pro 
1               5                   10                  15      


Pro Gly Trp Glu Val Gly Val Tyr Ala Ala Gly Ala Leu Ala Leu Leu 
            20                  25                  30          


Gly Ile Ala Ala Val Ser Leu Trp Lys Leu Trp Thr Ser Gly Ser Phe 
        35                  40                  45              


Pro Ser Pro Ser Pro Phe Pro Asn Tyr Asp Tyr Arg Tyr Leu Gln Gln 
    50                  55                  60                  


Lys Tyr Gly Glu Ser Cys Ala Glu Ala Arg Glu Lys Arg Val Pro Ala 
65                  70                  75                  80  


Trp Asn Ala Gln Arg Ala Ser Thr Arg Gly Pro Pro Ser Arg Lys Gly 
                85                  90                  95      


Ser Leu Ser Ile Glu Asp Thr Phe Glu Ser Ile Ser Glu Leu Gly Pro 
            100                 105                 110         


Leu Glu Leu Met Gly Arg Glu Leu Asp Leu Ala Pro Tyr Gly Thr Leu 
        115                 120                 125             


Arg Lys Ser Gln Ser Ala Asp Ser Leu Asn Ser Ile Ser Ser Val Ser 
    130                 135                 140                 


Asn Thr Phe Gly Gln Asp Phe Thr Leu Gly Gln Val Glu Val Ser Met 
145                 150                 155                 160 


Glu Tyr Asp Thr Ala Ser His Thr Leu Asn Val Ala Val Met Gln Gly 
                165                 170                 175     


Lys Asp Leu Leu Glu Arg Glu Glu Ala Ser Phe Glu Ser Cys Phe Met 
            180                 185                 190         


Arg Val Ser Leu Leu Pro Asp Glu Gln Ile Val Gly Ile Ser Arg Ile 
        195                 200                 205             


Gln Arg Asn Ala Tyr Ser Ile Phe Phe Asp Glu Lys Phe Ser Ile Pro 
    210                 215                 220                 


Leu Asp Pro Thr Ala Leu Glu Glu Lys Ser Leu Arg Phe Ser Val Phe 
225                 230                 235                 240 


Gly Ile Asp Glu Asp Glu Arg Asn Val Ser Thr Gly Val Val Glu Leu 
                245                 250                 255     


Lys Leu Ser Val Leu Asp Leu Pro Leu Gln Pro Phe Ser Gly Trp Leu 
            260                 265                 270         


Tyr Leu Gln Asp Gln Asn Lys Ala Ala Asp Ala Val Gly Glu Ile Leu 
        275                 280                 285             


Leu Ser Leu Ser Tyr Leu Pro Thr Ala Glu Arg Leu Thr Val Val Val 
    290                 295                 300                 


Val Lys Ala Lys Asn Leu Ile Trp Thr Asn Asp Lys Thr Thr Ala Asp 
305                 310                 315                 320 


Pro Phe Val Lys Val Tyr Leu Leu Gln Asp Gly Arg Lys Met Ser Lys 
                325                 330                 335     


Lys Lys Thr Ala Val Lys Arg Asp Asp Pro Asn Pro Val Phe Asn Glu 
            340                 345                 350         


Ala Met Ile Phe Ser Val Pro Ala Ile Val Leu Gln Asp Leu Ser Leu 
        355                 360                 365             


Arg Val Thr Val Ala Glu Ser Ser Ser Asp Gly Arg Gly Asp Asn Val 
    370                 375                 380                 


Gly His Val Ile Ile Gly Pro Ser Ala Ser Gly Met Gly Thr Thr His 
385                 390                 395                 400 


Trp Asn Gln Met Leu Ala Thr Leu Arg Arg Pro Val Ser Met Trp His 
                405                 410                 415     


Ala Val Arg Arg Asn 
            420     


<210>  2750
<211>  1111
<212>  DNA
<213>  Homosapiens

<400>  2750
ctgggtctct gcgccgcagc cgcccgcccg cccgctcagc gcccggcccc gggatgacgg     60

cggcccaggc cgcgggtgag gaggcgccac caggcgtgcg gtccgtcaag gtggtcctgg    120

tgggcgacgg cggctgcggg aagacgtcgc tgctgatggt cttcgccgat ggggccttcc    180

ccgagagcta cacccccacg gtgtttgagc ggtacatggt caacctgcaa gtgaaaggca    240

aacctgtgca cctccacatc tgggacacag cagggcaaga tgactatgac cgcctgcggc    300

ccctgttcta ccctgacgcc agcgtcctgc tgctttgctt cgatgtcacc agcccgaaca    360

gctttgacaa catctttaac cggtggtacc cagaagtgaa tcatttctgc aagaaggtac    420

ccatcatcgt cgtgggctgc aagactgacc tgcgcaagga caaatcactg gtgaacaagc    480

tccgaagaaa cggattggag cctgtgacct accacagggg ccaggagatg gcgaggtccg    540

tgggcgcggt ggcctacctc gagtgctcgg ctcggctcca tgacaacgtc cacgccgtct    600

tccaggaggc cgccgaggtg gccctcagca gccgcggtcg caacttctgg cggcggatta    660

cccagggctt ttgcgtggtg acctgagcgg ctcggggcgt cccagcgacg cgggaagggg    720

cagggcgctg acctgctgct gagctggctg ggctggaccc ggtccctagg ctgtgaccgc    780

cgaactccac tgcaacagac gggcgccacc aaagccaggc cctgaggcct gggagtcctg    840

gactgagaaa gggggttcct gggcccacct gctctgtgta gggctcgtcc tgcggtgccc    900

gagaatcact cgctaacccc tatgcccggt cccggaccga catcctggag ccgcctgtgc    960

agcctgatgc cccctcgtgg ctgctcccag ggctgcacct gccaggacct aatgttctta   1020

ggtccctctg gccagaaccc acacccggcc ccttcccacc tgtcatactg gtaactgtaa   1080

caagaaaaac gacatcaaaa aaaaaaaaaa a                                  1111


<210>  2751
<211>  210
<212>  PRT
<213>  Homosapiens

<400>  2751

Met Thr Ala Ala Gln Ala Ala Gly Glu Glu Ala Pro Pro Gly Val Arg 
1               5                   10                  15      


Ser Val Lys Val Val Leu Val Gly Asp Gly Gly Cys Gly Lys Thr Ser 
            20                  25                  30          


Leu Leu Met Val Phe Ala Asp Gly Ala Phe Pro Glu Ser Tyr Thr Pro 
        35                  40                  45              


Thr Val Phe Glu Arg Tyr Met Val Asn Leu Gln Val Lys Gly Lys Pro 
    50                  55                  60                  


Val His Leu His Ile Trp Asp Thr Ala Gly Gln Asp Asp Tyr Asp Arg 
65                  70                  75                  80  


Leu Arg Pro Leu Phe Tyr Pro Asp Ala Ser Val Leu Leu Leu Cys Phe 
                85                  90                  95      


Asp Val Thr Ser Pro Asn Ser Phe Asp Asn Ile Phe Asn Arg Trp Tyr 
            100                 105                 110         


Pro Glu Val Asn His Phe Cys Lys Lys Val Pro Ile Ile Val Val Gly 
        115                 120                 125             


Cys Lys Thr Asp Leu Arg Lys Asp Lys Ser Leu Val Asn Lys Leu Arg 
    130                 135                 140                 


Arg Asn Gly Leu Glu Pro Val Thr Tyr His Arg Gly Gln Glu Met Ala 
145                 150                 155                 160 


Arg Ser Val Gly Ala Val Ala Tyr Leu Glu Cys Ser Ala Arg Leu His 
                165                 170                 175     


Asp Asn Val His Ala Val Phe Gln Glu Ala Ala Glu Val Ala Leu Ser 
            180                 185                 190         


Ser Arg Gly Arg Asn Phe Trp Arg Arg Ile Thr Gln Gly Phe Cys Val 
        195                 200                 205             


Val Thr 
    210 


<210>  2752
<211>  6210
<212>  DNA
<213>  Homosapiens

<400>  2752
agaactcaag agcagaatct ccgtgttgca atctggttcc taaggaggaa gaggaaggca     60

gccctggagt ggtttcttta cagtaatttc aacagaagag tgagagatgg aacccgaaga    120

agaaaggatt cgttacagcc agagattgcg tggtaccatg cgacgacgct atgaagatga    180

tggcatttca gatgatgaaa ttgaaggaaa aagaactttt gacttggaag agaaactgca    240

caccaacaaa tataatgcca attttgttac ttttatggaa ggaaaagatt ttaatgtaga    300

gtatattcag cggggtggct tgagagatcc tctgattttc aagaattctg atggactcgg    360

aataaaaatg ccggatccag acttcactgt gaatgatgtc aaaatgtgtg tggggagtcg    420

tcgcatggtg gatgtcatgg acgtgaacac acagaaaggc attgaaatga ccatggctca    480

gtggacacgc tactatgaga ccccagagga ggagcgagag aaactctata atgtcatcag    540

cctcgagttt agccacacca ggctggagaa tatggtgcag aggccctcca cggtggattt    600

cattgactgg gtagacaaca tgtggccaag gcacttgaag gaaagccaga ctgaatcaac    660

aaatgccatc ttggagatgc agtaccctaa agtgcagaag tactgtctaa tgagtgttcg    720

aggctgctat actgacttcc atgtggactt tggtggtacc tctgtttggt atcacatcca    780

tcaaggggga aaggtcttct ggctcatccc ccctacagcc cacaacctgg agctgtacga    840

gaattggctg ctgtcaggga aacagggaga catctttctg ggtgaccggg tatcagattg    900

tcagcgcatt gagctcaagc agggctatac cttcgtcatt ccctcaggct ggattcatgc    960

tgtgtatact cctacagaca cattagtgtt tgggggcaat tttttgcata gcttcaacat   1020

ccctatgcag ttaaaaatat acaacattga agatcggaca cgggttccaa ataagtttcg   1080

ctatccattc tactatgaga tgtgttggta tgtgttggag cgctatgtgt actgcataac   1140

caaccgttcc cacctaacta aggaatttca gaaagagtcc ctcagcatgg atttggagtt   1200

aaatgggttg gagtctggga atggggatga ggaagcagtg gatcgagaac cccgacgctt   1260

gagcagcagg cgttctgtcc tcactagccc tgtagcgaat ggagtcaacc tggattatga   1320

tggactgggc aaaacctgcc gaagtcttcc aagtctgaag aaaactttgg ctggggactc   1380

atcttctgac tgtagccggg gctcccacaa tggacaagtg tgggatcccc agtgtgctcc   1440

ccgaaaggac aggcaagtgc atctgaccca ttttgagctt gaaggccttc gctgccttgt   1500

agataagttg gagtctctgc cactgcacaa gaaatgtgtc cccacaggga tagaagatga   1560

agatgctctc attgctgatg taaagatttt gctggaggag cttgccaaca gcgatcccaa   1620

gttagccctc actggagttc ctatagtaca gtggccaaaa agggataagc ttaaattccc   1680

cactcggcca aaggtgcggg ttcctaccat ccccattacg aagcctcaca ctatgaaacc   1740

agctccacgg ttaacacctg tgaggccagc tgctgcctcc ccgattgtgt caggagccag   1800

acggagacga gtgcgatgtc gaaaatgcaa agcctgtgtg caaggagagt gtggtgtttg   1860

ccactactgc agagacatga agaagtttgg ggggcctgga cgcatgaagc agtcctgtgt   1920

cctccgacag tgcttggcac ccagactgcc tcactcagtc acatgttccc tctgtggaga   1980

ggtggatcag aatgaagaga cacaagactt tgagaagaaa ctcatggaat gctgtatctg   2040

caatgagatt gttcatcctg gctgcctcca gatggacgga gaggggttgc ttaacgaaga   2100

attgccaaat tgctgggaat gtccaaagtg ctaccaggag gacagctcgg agaaagccca   2160

gaagcggaaa atggaagaga gtgacgaaga agctgtgcaa gccaaagtcc tgcggcccct   2220

gcggagctgc gatgagcctc tcacgccccc gcctcattca cccacttcca tgctgcagct   2280

catccatgac ccggtttccc cccggggtat ggtgactcgg tcatcccctg gggctggccc   2340

cagcgaccac cacagtgcca gccgcgatga gcgcttcaaa cggcggcagt tgctgcggct   2400

gcaggccaca gagcgcacca tggtacggga aaaggagaac aatcccagcg gcaaaaagga   2460

gctgtctgaa gttgagaaag ccaagatccg gggatcgtac ctcactgtca cgctacagag   2520

gcccaccaaa gagctccacg ggacatccat tgtgcccaag ctgcaggcca tcacggcctc   2580

ctctgccaac cttcgccatt ccccccgtgt gctagtgcag cactgcccag cccgaacccc   2640

ccagcgtggg gatgaggagg ggctgggggg agaggaggag gaagaggagg aggaggagga   2700

ggaagatgac agtgcagagg aggggggtgc agccaggctg aatggccggg gcagttgggc   2760

tcaggatgga gacgaaagct ggatgcagcg ggaggtctgg atgtctgtct tccgctacct   2820

cagccgcaga gaactttgtg aatgtatgcg agtgtgcaag acgtggtata aatggtgctg   2880

cgacaagaga ctttggacaa aaattgactt gagtaggtgt aaggccattg tgccccaggc   2940

cctcagtggc atcatcaaga ggcagccagt cagccttgac ctcagttgga ccaacatctc   3000

taaaaagcaa ctgacatggc tcgtcaatag gctgccagga ctgaaagacc tcctcctagc   3060

aggctgctcc tggtctgcag tctctgccct cagcacctcc agctgccccc ttctcaggac   3120

ccttgatctt cggtgggcag taggaatcaa ggaccctcaa attcgggact tgcttactcc   3180

accggctgat aaaccaggtc aggacaatcg cagcaagctc cggaacatga ccgacttccg   3240

gctggcaggc cttgacatca cagatgccac gcttcgcctc ataattcgcc acatgcccct   3300

cctgtctcga ctcgacctca gtcactgcag ccaccttaca gatcagtcct ccaatctact   3360

cactgctgtc gggtcttcca ctcgctactc tctcacagag ctcaatatgg caggttgcaa   3420

taaattgaca gaccagaccc tgatctacct acggcgcatt gccaacgtca ccttgatcga   3480

ccttcgagga tgcaagcaga tcactcgaaa agcctgcgag cacttcatct cagacttgtc   3540

catcaacagc ctctactgcc tgtctgacga gaagctgata cagaagatca gctaagacac   3600

acccagccca gattcaacag gaaaccgatc ttcccctgac tccccaccga ggagagcctc   3660

tcctcgaccc tgcacgggct ctgaggccag cgtcacactc cctctctgct ctcctgtccc   3720

ttgagccctt cctctacagg tggggcagag agggtggtgg acaccaggct tatctgcctg   3780

ctcctctccc tcctaaggaa aagggagtag cagattgatc tgaggggaaa gcacaggctg   3840

tgctgtcgag gcgcctgctc gcttactcgc ctgccaggag gccgggctct cagtttgggg   3900

tgtttgtgca accttcatct gcactgggcc ctgtgcccct cctccccatc catggtcccc   3960

agcagtgcct ggttctgagc aaactcccag ggaagaaaac ggccctgtct ccatggccag   4020

gttcttgtgg tgtccagtgc gcgtctctcc tccatcacac tctcccggct tgcgcaggag   4080

gggccagcag ccccaggagt cccagacccg tgccgatcac actggtgctg ttgagatctc   4140

ccaaacctca cgtccttaac tgtgctctcc ctcctttcct ctcccttgag cttggttctg   4200

cccagcactc gtgcttgttc acataattag gtttcccacc ccagcctacc cgacttactt   4260

gctagtctct atgaggtcct tattgcactt attggggttg aagctcttca gaggagctgg   4320

aactgtctac cccagggaca cacccatttc gttgctaccc aagtggattc tgagacaggc   4380

accatctcct tgttccccct ctctcttttg cctcccactg actgcccttt tccatgtgtc   4440

ttcattctgc ctgaagaagg ctttcccagg atgcacgtcc tcagagggag cagcctatct   4500

cccccaagct ggaggcggca gaggactggg ccaagcccca acctgcctcc cagccaggct   4560

cctccaggcc tctggtttag cggagccccc tgagcccagg cctgtgtcta gccccagtgg   4620

ctcactgaac tttcagggca gtcagggggt cctgcttaga agccagtcac cagccctctg   4680

cctgcagcca tggaaggggg tgtgcacgtg cctctgtgtg tgtggctgag tgtattctgc   4740

gcgtgtgtgt ggagggaggg agggagggga gcatggtgtc tcccgctcca ccgccctttg   4800

ttgagcccca tcagctgccc ccttttactt tgcattgaac ggcctgtcca aagatcctct   4860

ctctagggca gcagagagct ttttgcactt taaaaaaaaa aagaaagaaa gaaaggtcgg   4920

aatttctttt gggtcaatat ttttaagtgt gtgaggagat gctcagtagc agcagcctat   4980

ggcaagagct tataaatgat tgatgcaaat ttgcactctg ctccccctct gtaaggatac   5040

tgatagcaca acctcttccc cccaccccgc cccgcctttt ggtcgtccat ccctgtccct   5100

ttctggccct cttcctgtag cccagtctca ggctttcctc ttcctgaagc cctacagagt   5160

tagggaatgg agcccaggca ccaggggtct aaagtgtgag ccactgagaa gagagacgcc   5220

aactgcaccc ttgccacttc caaagcaata gaggcagagt ggtcccctct ttgccaccta   5280

ggccagtttt gaccctggca ttaactggcc ttagaagaaa ctggatcctg gtagggggtg   5340

gcattttgtt tgtttcttcc aatctgctga atcttttgac tgcaccttac aaacagcagt   5400

ctgctcccat gaccctctgc ccacttccat tggtctccag gccccaataa tctggggttg   5460

aaactttgag gaaatgccag tgacttattc cagagtgcct cagttagggg aacttctctg   5520

taaagaaccc tgggtattga gcaaaaacct tattatcgtt aatgacctat aattggaagc   5580

ttcctgcctt tttctttggt tgctcctgtg gaaaatactg aaaagattac tttgttttat   5640

tttgttgtct ttttataaaa ggggaggtgg agagacccct tcagagcagg gattgtgccg   5700

ggagagtgcc tctgactttg ggacatttca tccacagaaa tttccaagcc aatggtttct   5760

tttgggtttt ggtttttatg tttgtttttt ggggtttgga aaaacatgca tttttaccgt   5820

gcacgtaaat tggtcagcag aaaagggagc ccagaaaagg cagcagatgg accatgccct   5880

tgctgggttt tccttttctt tgggactgtg aggggaaatg gtttttagag gtgagggttg   5940

gtccatgtgg aggaaagaag tgtctctgtt gggggacaga ggaacctggg gagtccatcg   6000

catgtcctac aatctgctct tagacacggc cttgccagga gagcctgccc tcagactgca   6060

ggaccagaac ccctgcctcc atctttccaa gcaccggggc gaaaaaccac aaaggaaagg   6120

aagaaaattt atatatatat aatataaaat cacttggtga ttaaaaaaat aactgctcca   6180

taaataaaac tcctaaagtc acttatgttt                                    6210


<210>  2753
<211>  1162
<212>  PRT
<213>  Homosapiens

<400>  2753

Met Glu Pro Glu Glu Glu Arg Ile Arg Tyr Ser Gln Arg Leu Arg Gly 
1               5                   10                  15      


Thr Met Arg Arg Arg Tyr Glu Asp Asp Gly Ile Ser Asp Asp Glu Ile 
            20                  25                  30          


Glu Gly Lys Arg Thr Phe Asp Leu Glu Glu Lys Leu His Thr Asn Lys 
        35                  40                  45              


Tyr Asn Ala Asn Phe Val Thr Phe Met Glu Gly Lys Asp Phe Asn Val 
    50                  55                  60                  


Glu Tyr Ile Gln Arg Gly Gly Leu Arg Asp Pro Leu Ile Phe Lys Asn 
65                  70                  75                  80  


Ser Asp Gly Leu Gly Ile Lys Met Pro Asp Pro Asp Phe Thr Val Asn 
                85                  90                  95      


Asp Val Lys Met Cys Val Gly Ser Arg Arg Met Val Asp Val Met Asp 
            100                 105                 110         


Val Asn Thr Gln Lys Gly Ile Glu Met Thr Met Ala Gln Trp Thr Arg 
        115                 120                 125             


Tyr Tyr Glu Thr Pro Glu Glu Glu Arg Glu Lys Leu Tyr Asn Val Ile 
    130                 135                 140                 


Ser Leu Glu Phe Ser His Thr Arg Leu Glu Asn Met Val Gln Arg Pro 
145                 150                 155                 160 


Ser Thr Val Asp Phe Ile Asp Trp Val Asp Asn Met Trp Pro Arg His 
                165                 170                 175     


Leu Lys Glu Ser Gln Thr Glu Ser Thr Asn Ala Ile Leu Glu Met Gln 
            180                 185                 190         


Tyr Pro Lys Val Gln Lys Tyr Cys Leu Met Ser Val Arg Gly Cys Tyr 
        195                 200                 205             


Thr Asp Phe His Val Asp Phe Gly Gly Thr Ser Val Trp Tyr His Ile 
    210                 215                 220                 


His Gln Gly Gly Lys Val Phe Trp Leu Ile Pro Pro Thr Ala His Asn 
225                 230                 235                 240 


Leu Glu Leu Tyr Glu Asn Trp Leu Leu Ser Gly Lys Gln Gly Asp Ile 
                245                 250                 255     


Phe Leu Gly Asp Arg Val Ser Asp Cys Gln Arg Ile Glu Leu Lys Gln 
            260                 265                 270         


Gly Tyr Thr Phe Val Ile Pro Ser Gly Trp Ile His Ala Val Tyr Thr 
        275                 280                 285             


Pro Thr Asp Thr Leu Val Phe Gly Gly Asn Phe Leu His Ser Phe Asn 
    290                 295                 300                 


Ile Pro Met Gln Leu Lys Ile Tyr Asn Ile Glu Asp Arg Thr Arg Val 
305                 310                 315                 320 


Pro Asn Lys Phe Arg Tyr Pro Phe Tyr Tyr Glu Met Cys Trp Tyr Val 
                325                 330                 335     


Leu Glu Arg Tyr Val Tyr Cys Ile Thr Asn Arg Ser His Leu Thr Lys 
            340                 345                 350         


Glu Phe Gln Lys Glu Ser Leu Ser Met Asp Leu Glu Leu Asn Gly Leu 
        355                 360                 365             


Glu Ser Gly Asn Gly Asp Glu Glu Ala Val Asp Arg Glu Pro Arg Arg 
    370                 375                 380                 


Leu Ser Ser Arg Arg Ser Val Leu Thr Ser Pro Val Ala Asn Gly Val 
385                 390                 395                 400 


Asn Leu Asp Tyr Asp Gly Leu Gly Lys Thr Cys Arg Ser Leu Pro Ser 
                405                 410                 415     


Leu Lys Lys Thr Leu Ala Gly Asp Ser Ser Ser Asp Cys Ser Arg Gly 
            420                 425                 430         


Ser His Asn Gly Gln Val Trp Asp Pro Gln Cys Ala Pro Arg Lys Asp 
        435                 440                 445             


Arg Gln Val His Leu Thr His Phe Glu Leu Glu Gly Leu Arg Cys Leu 
    450                 455                 460                 


Val Asp Lys Leu Glu Ser Leu Pro Leu His Lys Lys Cys Val Pro Thr 
465                 470                 475                 480 


Gly Ile Glu Asp Glu Asp Ala Leu Ile Ala Asp Val Lys Ile Leu Leu 
                485                 490                 495     


Glu Glu Leu Ala Asn Ser Asp Pro Lys Leu Ala Leu Thr Gly Val Pro 
            500                 505                 510         


Ile Val Gln Trp Pro Lys Arg Asp Lys Leu Lys Phe Pro Thr Arg Pro 
        515                 520                 525             


Lys Val Arg Val Pro Thr Ile Pro Ile Thr Lys Pro His Thr Met Lys 
    530                 535                 540                 


Pro Ala Pro Arg Leu Thr Pro Val Arg Pro Ala Ala Ala Ser Pro Ile 
545                 550                 555                 560 


Val Ser Gly Ala Arg Arg Arg Arg Val Arg Cys Arg Lys Cys Lys Ala 
                565                 570                 575     


Cys Val Gln Gly Glu Cys Gly Val Cys His Tyr Cys Arg Asp Met Lys 
            580                 585                 590         


Lys Phe Gly Gly Pro Gly Arg Met Lys Gln Ser Cys Val Leu Arg Gln 
        595                 600                 605             


Cys Leu Ala Pro Arg Leu Pro His Ser Val Thr Cys Ser Leu Cys Gly 
    610                 615                 620                 


Glu Val Asp Gln Asn Glu Glu Thr Gln Asp Phe Glu Lys Lys Leu Met 
625                 630                 635                 640 


Glu Cys Cys Ile Cys Asn Glu Ile Val His Pro Gly Cys Leu Gln Met 
                645                 650                 655     


Asp Gly Glu Gly Leu Leu Asn Glu Glu Leu Pro Asn Cys Trp Glu Cys 
            660                 665                 670         


Pro Lys Cys Tyr Gln Glu Asp Ser Ser Glu Lys Ala Gln Lys Arg Lys 
        675                 680                 685             


Met Glu Glu Ser Asp Glu Glu Ala Val Gln Ala Lys Val Leu Arg Pro 
    690                 695                 700                 


Leu Arg Ser Cys Asp Glu Pro Leu Thr Pro Pro Pro His Ser Pro Thr 
705                 710                 715                 720 


Ser Met Leu Gln Leu Ile His Asp Pro Val Ser Pro Arg Gly Met Val 
                725                 730                 735     


Thr Arg Ser Ser Pro Gly Ala Gly Pro Ser Asp His His Ser Ala Ser 
            740                 745                 750         


Arg Asp Glu Arg Phe Lys Arg Arg Gln Leu Leu Arg Leu Gln Ala Thr 
        755                 760                 765             


Glu Arg Thr Met Val Arg Glu Lys Glu Asn Asn Pro Ser Gly Lys Lys 
    770                 775                 780                 


Glu Leu Ser Glu Val Glu Lys Ala Lys Ile Arg Gly Ser Tyr Leu Thr 
785                 790                 795                 800 


Val Thr Leu Gln Arg Pro Thr Lys Glu Leu His Gly Thr Ser Ile Val 
                805                 810                 815     


Pro Lys Leu Gln Ala Ile Thr Ala Ser Ser Ala Asn Leu Arg His Ser 
            820                 825                 830         


Pro Arg Val Leu Val Gln His Cys Pro Ala Arg Thr Pro Gln Arg Gly 
        835                 840                 845             


Asp Glu Glu Gly Leu Gly Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    850                 855                 860                 


Glu Glu Asp Asp Ser Ala Glu Glu Gly Gly Ala Ala Arg Leu Asn Gly 
865                 870                 875                 880 


Arg Gly Ser Trp Ala Gln Asp Gly Asp Glu Ser Trp Met Gln Arg Glu 
                885                 890                 895     


Val Trp Met Ser Val Phe Arg Tyr Leu Ser Arg Arg Glu Leu Cys Glu 
            900                 905                 910         


Cys Met Arg Val Cys Lys Thr Trp Tyr Lys Trp Cys Cys Asp Lys Arg 
        915                 920                 925             


Leu Trp Thr Lys Ile Asp Leu Ser Arg Cys Lys Ala Ile Val Pro Gln 
    930                 935                 940                 


Ala Leu Ser Gly Ile Ile Lys Arg Gln Pro Val Ser Leu Asp Leu Ser 
945                 950                 955                 960 


Trp Thr Asn Ile Ser Lys Lys Gln Leu Thr Trp Leu Val Asn Arg Leu 
                965                 970                 975     


Pro Gly Leu Lys Asp Leu Leu Leu Ala Gly Cys Ser Trp Ser Ala Val 
            980                 985                 990         


Ser Ala Leu Ser Thr Ser Ser Cys  Pro Leu Leu Arg Thr  Leu Asp Leu 
        995                 1000                 1005             


Arg Trp  Ala Val Gly Ile Lys  Asp Pro Gln Ile Arg  Asp Leu Leu 
    1010                 1015                 1020             


Thr Pro  Pro Ala Asp Lys Pro  Gly Gln Asp Asn Arg  Ser Lys Leu 
    1025                 1030                 1035             


Arg Asn  Met Thr Asp Phe Arg  Leu Ala Gly Leu Asp  Ile Thr Asp 
    1040                 1045                 1050             


Ala Thr  Leu Arg Leu Ile Ile  Arg His Met Pro Leu  Leu Ser Arg 
    1055                 1060                 1065             


Leu Asp  Leu Ser His Cys Ser  His Leu Thr Asp Gln  Ser Ser Asn 
    1070                 1075                 1080             


Leu Leu  Thr Ala Val Gly Ser  Ser Thr Arg Tyr Ser  Leu Thr Glu 
    1085                 1090                 1095             


Leu Asn  Met Ala Gly Cys Asn  Lys Leu Thr Asp Gln  Thr Leu Ile 
    1100                 1105                 1110             


Tyr Leu  Arg Arg Ile Ala Asn  Val Thr Leu Ile Asp  Leu Arg Gly 
    1115                 1120                 1125             


Cys Lys  Gln Ile Thr Arg Lys  Ala Cys Glu His Phe  Ile Ser Asp 
    1130                 1135                 1140             


Leu Ser  Ile Asn Ser Leu Tyr  Cys Leu Ser Asp Glu  Lys Leu Ile 
    1145                 1150                 1155             


Gln Lys  Ile Ser 
    1160         


<210>  2754
<211>  3603
<212>  DNA
<213>  Homosapiens

<400>  2754
ctcggcctcg ggcgcggccg agcgccgcgc gagcaggagc ggcggcggcg gcggcggcgg     60

cgggaggagg cagcgccggc ccaagatggc ggacctggag gcggtgctgg ccgacgtgag    120

ctacctgatg gccatggaga agagcaaggc cacgccggcc gcgcgcgcca gcaagaagat    180

actgctgccc gagcccagca tccgcagtgt catgcagaag tacctggagg accggggcga    240

ggtgaccttt gagaagatct tttcccagaa gctggggtac ctgctcttcc gagacttctg    300

cctgaaccac ctggaggagg ccaggccctt ggtggaattc tatgaggaga tcaagaagta    360

cgagaagctg gagacggagg aggagcgtgt ggcccgcagc cgggagatct tcgactcata    420

catcatgaag gagctgctgg cctgctcgca tcccttctcg aagagtgcca ctgagcatgt    480

ccaaggccac ctggggaaga agcaggtgcc tccggatctc ttccagccat acatcgaaga    540

gatttgtcaa aacctccgag gggacgtgtt ccagaaattc attgagagcg ataagttcac    600

acggttttgc cagtggaaga atgtggagct caacatccac ctgaccatga atgacttcag    660

cgtgcatcgc atcattgggc gcgggggctt tggcgaggtc tatgggtgcc ggaagcgtga    720

cacaggcaag atgtacgcca tgaagtgcct ggacaaaaag cgcatcaaga tgaagcaggg    780

ggagaccctg gccctgaacg agcgcatcat gctctcgctc gtcagcactg gggactgccc    840

attcattgtc tgcatgtcat acgcgttcca cacgccagac aagctcagct tcatcctgga    900

cctcatgaac ggtggggacc tgcactacca cctctcccag cacggggtct tctcagaggc    960

tgacatgcgc ttctatgcgg ccgagatcat cctgggcctg gagcacatgc acaaccgctt   1020

cgtggtctac cgggacctga agccagccaa catccttctg gacgagcatg gccacgtgcg   1080

gatctcggac ctgggcctgg cctgtgactt ctccaagaag aagccccatg ccagcgtggg   1140

cacccacggg tacatggctc cggaggtcct gcagaagggc gtggcctacg acagcagtgc   1200

cgactggttc tctctggggt gcatgctctt caagttgctg cgggggcaca gccccttccg   1260

gcagcacaag accaaagaca agcatgagat cgaccgcatg acgctgacga tggccgtgga   1320

gctgcccgac tccttctccc ctgaactaca ctccctgctg gaggggttgc tgcagaggga   1380

tgtcaaccgg agattgggct gcctgggccg aggggctcag gaggtgaaag agagcccctt   1440

tttccgctcc ctggactggc agatggtctt cttgcagagg taccctcccc cgctgatccc   1500

cccacgaggg gaggtgaacg cggccgacgc cttcgacatt ggctccttcg atgaggagga   1560

cacaaaagga atcaagttac tggacagtga tcaggagctc taccgcaact tccccctcac   1620

catctcggag cggtggcagc aggaggtggc agagactgtc ttcgacacca tcaacgctga   1680

gacagaccgg ctggaggctc gcaagaaagc caagaacaag cagctgggcc atgaggaaga   1740

ctacgccctg ggcaaggact gcatcatgca tggctacatg tccaagatgg gcaacccctt   1800

tctgacccag tggcagcggc ggtacttcta cctgttcccc aaccgcctcg agtggcgggg   1860

cgagggcgag gccccgcaga gcctgctgac catggaggag atccagtcgg tggaggagac   1920

gcagatcaag gagcgcaagt gcctgctcct caagatccgc ggtgggaaac agttcatttt   1980

gcagtgcgat agcgaccctg agctggtgca gtggaagaag gagctgcgcg acgcctaccg   2040

cgaggcccag cagctggtgc agcgggtgcc caagatgaag aacaagccgc gctcgcccgt   2100

ggtggagctg agcaaggtgc cgctggtcca gcgcggcagt gccaacggcc tctgacccgc   2160

ccacccgcct tttataaacc tctaatttat tttgtcgaat ttttattatt tgttttcccg   2220

ccaagcgaaa aggttttatt ttgtaattat tgtgatttcc cgtggcccca gcctggccca   2280

gctcccccgg gaggccccgc ttgcctcggc tcctgctgca ccaacccagc cgctgcccgg   2340

cgccctctgt cctgacttca ggggctgccc gctcccagtg tcttcctgtg ggggaagagc   2400

acagccctcc cgccccttcc ccgagggatg atgccacacc aagctgtgcc accctgggct   2460

ctgtgggctg cacttgtgcc atgggactgt gggtggccca tcccccctca ccaggggcag   2520

gcacagcaca gggatccgac ttgaattttc ccactgcacc ccctcctgct gcagaggggc   2580

aggccctgca ctgtcctgct ccacagtgtt ggcgagagga ggggcccgtt gtctccctgg   2640

ccctcaaggc tcccacagtg actcgggctc ctgtgccctt attcaggaaa agcctctgtg   2700

tcactggctg cctccactcc cacttccctg acactgcggg gcttggctga gagagtggca   2760

ttggcagcag gtgctgctac cctccctgct gtcccctctt gccccaaccc ccagcacccg   2820

ggctcaggga ccacagcaag gcacctgcag gttgggccat actggcctcg cctggcctga   2880

ggtctcgctg atgctgggct gggtgcgacc ccatctgccc aggacggggc cggccaggtg   2940

ggcgggcagc acagcaagga ggctggctgg ggcctatcag tgtgcccccc atcctggccc   3000

atcagtgtac ccccgcccag actggccagc cccacagccc acgtcctgtc agtgccgccg   3060

cctcgcccac cgcatgcccc ctgtgccagt gctctgcctg tgtgtgtgca ctcgtgtcgc   3120

gccttctccc ccccggggct gggttggcgc accctcccct cccgtctact cattccccgg   3180

ggcgtttctt tgccgatttt tgaatgtgat tttaaagagt gaaaaatgag actatgcgtt   3240

tttataaaaa atggtgcctg attcggctgt ctcagactct ttttgtacct ggtgacccct   3300

tttcagcttc tgctgggctg gggcctgatg gggagggtct cggtggtacc aggtctcctc   3360

caccgccatg gcttccaagg tggtctgctc gggcccaggc catcttccag gtggggtgag   3420

gcagtgggtc ccacttcccc tcctacccct cccagctgac agtcctctcc acctagtggc   3480

tgtccagtgc ccattcctca ccttttcccg gggaggagag agcagcttct gccacttccc   3540

aggtaagcag gaggaggtgc caacagtgtt aggcctggca cagtgtctgg gtgatcggga   3600

cct                                                                 3603


<210>  2755
<211>  689
<212>  PRT
<213>  Homosapiens

<400>  2755

Met Ala Asp Leu Glu Ala Val Leu Ala Asp Val Ser Tyr Leu Met Ala 
1               5                   10                  15      


Met Glu Lys Ser Lys Ala Thr Pro Ala Ala Arg Ala Ser Lys Lys Ile 
            20                  25                  30          


Leu Leu Pro Glu Pro Ser Ile Arg Ser Val Met Gln Lys Tyr Leu Glu 
        35                  40                  45              


Asp Arg Gly Glu Val Thr Phe Glu Lys Ile Phe Ser Gln Lys Leu Gly 
    50                  55                  60                  


Tyr Leu Leu Phe Arg Asp Phe Cys Leu Asn His Leu Glu Glu Ala Arg 
65                  70                  75                  80  


Pro Leu Val Glu Phe Tyr Glu Glu Ile Lys Lys Tyr Glu Lys Leu Glu 
                85                  90                  95      


Thr Glu Glu Glu Arg Val Ala Arg Ser Arg Glu Ile Phe Asp Ser Tyr 
            100                 105                 110         


Ile Met Lys Glu Leu Leu Ala Cys Ser His Pro Phe Ser Lys Ser Ala 
        115                 120                 125             


Thr Glu His Val Gln Gly His Leu Gly Lys Lys Gln Val Pro Pro Asp 
    130                 135                 140                 


Leu Phe Gln Pro Tyr Ile Glu Glu Ile Cys Gln Asn Leu Arg Gly Asp 
145                 150                 155                 160 


Val Phe Gln Lys Phe Ile Glu Ser Asp Lys Phe Thr Arg Phe Cys Gln 
                165                 170                 175     


Trp Lys Asn Val Glu Leu Asn Ile His Leu Thr Met Asn Asp Phe Ser 
            180                 185                 190         


Val His Arg Ile Ile Gly Arg Gly Gly Phe Gly Glu Val Tyr Gly Cys 
        195                 200                 205             


Arg Lys Arg Asp Thr Gly Lys Met Tyr Ala Met Lys Cys Leu Asp Lys 
    210                 215                 220                 


Lys Arg Ile Lys Met Lys Gln Gly Glu Thr Leu Ala Leu Asn Glu Arg 
225                 230                 235                 240 


Ile Met Leu Ser Leu Val Ser Thr Gly Asp Cys Pro Phe Ile Val Cys 
                245                 250                 255     


Met Ser Tyr Ala Phe His Thr Pro Asp Lys Leu Ser Phe Ile Leu Asp 
            260                 265                 270         


Leu Met Asn Gly Gly Asp Leu His Tyr His Leu Ser Gln His Gly Val 
        275                 280                 285             


Phe Ser Glu Ala Asp Met Arg Phe Tyr Ala Ala Glu Ile Ile Leu Gly 
    290                 295                 300                 


Leu Glu His Met His Asn Arg Phe Val Val Tyr Arg Asp Leu Lys Pro 
305                 310                 315                 320 


Ala Asn Ile Leu Leu Asp Glu His Gly His Val Arg Ile Ser Asp Leu 
                325                 330                 335     


Gly Leu Ala Cys Asp Phe Ser Lys Lys Lys Pro His Ala Ser Val Gly 
            340                 345                 350         


Thr His Gly Tyr Met Ala Pro Glu Val Leu Gln Lys Gly Val Ala Tyr 
        355                 360                 365             


Asp Ser Ser Ala Asp Trp Phe Ser Leu Gly Cys Met Leu Phe Lys Leu 
    370                 375                 380                 


Leu Arg Gly His Ser Pro Phe Arg Gln His Lys Thr Lys Asp Lys His 
385                 390                 395                 400 


Glu Ile Asp Arg Met Thr Leu Thr Met Ala Val Glu Leu Pro Asp Ser 
                405                 410                 415     


Phe Ser Pro Glu Leu His Ser Leu Leu Glu Gly Leu Leu Gln Arg Asp 
            420                 425                 430         


Val Asn Arg Arg Leu Gly Cys Leu Gly Arg Gly Ala Gln Glu Val Lys 
        435                 440                 445             


Glu Ser Pro Phe Phe Arg Ser Leu Asp Trp Gln Met Val Phe Leu Gln 
    450                 455                 460                 


Arg Tyr Pro Pro Pro Leu Ile Pro Pro Arg Gly Glu Val Asn Ala Ala 
465                 470                 475                 480 


Asp Ala Phe Asp Ile Gly Ser Phe Asp Glu Glu Asp Thr Lys Gly Ile 
                485                 490                 495     


Lys Leu Leu Asp Ser Asp Gln Glu Leu Tyr Arg Asn Phe Pro Leu Thr 
            500                 505                 510         


Ile Ser Glu Arg Trp Gln Gln Glu Val Ala Glu Thr Val Phe Asp Thr 
        515                 520                 525             


Ile Asn Ala Glu Thr Asp Arg Leu Glu Ala Arg Lys Lys Ala Lys Asn 
    530                 535                 540                 


Lys Gln Leu Gly His Glu Glu Asp Tyr Ala Leu Gly Lys Asp Cys Ile 
545                 550                 555                 560 


Met His Gly Tyr Met Ser Lys Met Gly Asn Pro Phe Leu Thr Gln Trp 
                565                 570                 575     


Gln Arg Arg Tyr Phe Tyr Leu Phe Pro Asn Arg Leu Glu Trp Arg Gly 
            580                 585                 590         


Glu Gly Glu Ala Pro Gln Ser Leu Leu Thr Met Glu Glu Ile Gln Ser 
        595                 600                 605             


Val Glu Glu Thr Gln Ile Lys Glu Arg Lys Cys Leu Leu Leu Lys Ile 
    610                 615                 620                 


Arg Gly Gly Lys Gln Phe Ile Leu Gln Cys Asp Ser Asp Pro Glu Leu 
625                 630                 635                 640 


Val Gln Trp Lys Lys Glu Leu Arg Asp Ala Tyr Arg Glu Ala Gln Gln 
                645                 650                 655     


Leu Val Gln Arg Val Pro Lys Met Lys Asn Lys Pro Arg Ser Pro Val 
            660                 665                 670         


Val Glu Leu Ser Lys Val Pro Leu Val Gln Arg Gly Ser Ala Asn Gly 
        675                 680                 685             


Leu 
    


<210>  2756
<211>  2219
<212>  DNA
<213>  Homosapiens

<400>  2756
actgctgcgg gggccgcggg gggcgcagct ggggcgcggc tcggagggga ggctaggggg     60

ccgtgccagg cccgaagccg aggcggggcc gggatgcggc gctgaggccc agcatggccg    120

gcccgggccc caccttcccg ctgcaccggc tcgtctgggc gaaccggcat cgcgaactgg    180

aggccgcact gcacagccac caggttccgc caaactcctg acaacctgca gctctgcctg    240

accaggcccc gccgccagac cccggctctg cccctgcctt ccctcctgcc ccctcctctc    300

ccctgccagg acacgcaggc caccctctgc catctccctg cacgacattg aacaggagga    360

cccccgcggg cggaccccac tggagctggc cgtgtctctg ggaaacctgg agtctgtgag    420

agtgctcctt cgacacaatg ccaacgtggg caaagagaac cgccagggct gggcagtcct    480

gcaggaggca gtcagcactg gagaccccga gatggtgcag ctggtgctcc agtatcggga    540

ctaccagagg gccacgcaga ggctggcggg cattccggaa ctgctcaaca aacttcgcca    600

ggcccccgat ttctacgttg agatgaagtg ggagttcacc agctgggtgc cccttgtgtc    660

taagatgtgc ccaagcgatg tgtaccgcgt gtggaagcgg ggtgagagcc tgcgagtaga    720

caccagtctc ctgggcttcg agcacgtgac ctggcagcgg ggccggagga gcttcatctt    780

caagggccag gaggcaggag ccctggtgat ggaagtggac catgaccggc aggtggtgca    840

tgtggagaca ctggggctca ctctgcagga gcccgaaaca ctgctggccg ccatgcggcc    900

cagcgaggag catgtggcca gtcgcctcac ctctcctatc gtctccaccc acctggacac    960

tcgtaatgtg gcctttgaga ggaacaaatg tggtatctgg ggctggcggt ctgagaagat   1020

ggaaactgtt agcggctacg aggccaaggt gtacagtgcc accaacgtgg agctggtgac   1080

acgcacacgc acggagcacc tctctgatca ggacaagtcg aggagcaaag cggggaagac   1140

tccattccag tccttcctgg ggatggcgca gcagcattcc tcccacaccg gggcccccgt   1200

gcagcaggca gccagcccca ccaaccccac agccatctcc cctgaggagt acttcgaccc   1260

caacttcagc ctggagtcac ggaacattgg ccgccccatc gagatgtcca gcaaagtaca   1320

gaggttcaag gcaacactgt ggctgagtga agagcacccg ctctccctgg gtgaccaggt   1380

gacccccatc atcgacctaa tggccatcag caacgctcac tttgccaagc tgcgcgactt   1440

catcactctg cgccttccac ctggcttccc cgtcaaaatt gagattcccc ttttccacgt   1500

gctcaatgcc cgcatcacct tcagcaacct gtgtggctgt gatgagcccc tgagctccgt   1560

gtgggtgccg gcccccagct ctgctgtcgc cgcatcaggg aaccctttcc cgtgcgaggt   1620

ggaccccacc gtgtttgaag tgcccaacgg gtacagcgtg ctgggcatgg agcgcaacga   1680

gcccctccgg gacgaggacg atgacctcct gcagttcgcc atccagcaga gcctgcttga   1740

agcgggcact gaggcggagc aggtgaccgt ctgggaagcc ctgaccaaca cccggcccgg   1800

tgcccgccct cctccccagg ccacggttta tgaggaacag cttcagctgg agcgggccct   1860

ccaggaaagc ctgcagctgt ccacagagcc caggggccca ggatcccctc ccaggacacc   1920

cccagccccc ggtccaccca gctttgaaga gcagctgcgc ctggccctgg agttgtcttc   1980

acgggagcag gaggagcggg agcggcgcgg gcagcaggag gaggaggact tacagcggat   2040

cctgcagctg tcactcactg agcactgagc catagccccg ggagggctgg ccaggccact   2100

ccctgcccac ttttgtaatt tatttattta taaactctct gctgctgagc ttggggcctg   2160

gagccccagg aatgagcagg caggggagac tgagatggaa ataaagagac tgtcgcagc    2219


<210>  2757
<211>  518
<212>  PRT
<213>  Homosapiens

<400>  2757

Met Val Gln Leu Val Leu Gln Tyr Arg Asp Tyr Gln Arg Ala Thr Gln 
1               5                   10                  15      


Arg Leu Ala Gly Ile Pro Glu Leu Leu Asn Lys Leu Arg Gln Ala Pro 
            20                  25                  30          


Asp Phe Tyr Val Glu Met Lys Trp Glu Phe Thr Ser Trp Val Pro Leu 
        35                  40                  45              


Val Ser Lys Met Cys Pro Ser Asp Val Tyr Arg Val Trp Lys Arg Gly 
    50                  55                  60                  


Glu Ser Leu Arg Val Asp Thr Ser Leu Leu Gly Phe Glu His Val Thr 
65                  70                  75                  80  


Trp Gln Arg Gly Arg Arg Ser Phe Ile Phe Lys Gly Gln Glu Ala Gly 
                85                  90                  95      


Ala Leu Val Met Glu Val Asp His Asp Arg Gln Val Val His Val Glu 
            100                 105                 110         


Thr Leu Gly Leu Thr Leu Gln Glu Pro Glu Thr Leu Leu Ala Ala Met 
        115                 120                 125             


Arg Pro Ser Glu Glu His Val Ala Ser Arg Leu Thr Ser Pro Ile Val 
    130                 135                 140                 


Ser Thr His Leu Asp Thr Arg Asn Val Ala Phe Glu Arg Asn Lys Cys 
145                 150                 155                 160 


Gly Ile Trp Gly Trp Arg Ser Glu Lys Met Glu Thr Val Ser Gly Tyr 
                165                 170                 175     


Glu Ala Lys Val Tyr Ser Ala Thr Asn Val Glu Leu Val Thr Arg Thr 
            180                 185                 190         


Arg Thr Glu His Leu Ser Asp Gln Asp Lys Ser Arg Ser Lys Ala Gly 
        195                 200                 205             


Lys Thr Pro Phe Gln Ser Phe Leu Gly Met Ala Gln Gln His Ser Ser 
    210                 215                 220                 


His Thr Gly Ala Pro Val Gln Gln Ala Ala Ser Pro Thr Asn Pro Thr 
225                 230                 235                 240 


Ala Ile Ser Pro Glu Glu Tyr Phe Asp Pro Asn Phe Ser Leu Glu Ser 
                245                 250                 255     


Arg Asn Ile Gly Arg Pro Ile Glu Met Ser Ser Lys Val Gln Arg Phe 
            260                 265                 270         


Lys Ala Thr Leu Trp Leu Ser Glu Glu His Pro Leu Ser Leu Gly Asp 
        275                 280                 285             


Gln Val Thr Pro Ile Ile Asp Leu Met Ala Ile Ser Asn Ala His Phe 
    290                 295                 300                 


Ala Lys Leu Arg Asp Phe Ile Thr Leu Arg Leu Pro Pro Gly Phe Pro 
305                 310                 315                 320 


Val Lys Ile Glu Ile Pro Leu Phe His Val Leu Asn Ala Arg Ile Thr 
                325                 330                 335     


Phe Ser Asn Leu Cys Gly Cys Asp Glu Pro Leu Ser Ser Val Trp Val 
            340                 345                 350         


Pro Ala Pro Ser Ser Ala Val Ala Ala Ser Gly Asn Pro Phe Pro Cys 
        355                 360                 365             


Glu Val Asp Pro Thr Val Phe Glu Val Pro Asn Gly Tyr Ser Val Leu 
    370                 375                 380                 


Gly Met Glu Arg Asn Glu Pro Leu Arg Asp Glu Asp Asp Asp Leu Leu 
385                 390                 395                 400 


Gln Phe Ala Ile Gln Gln Ser Leu Leu Glu Ala Gly Thr Glu Ala Glu 
                405                 410                 415     


Gln Val Thr Val Trp Glu Ala Leu Thr Asn Thr Arg Pro Gly Ala Arg 
            420                 425                 430         


Pro Pro Pro Gln Ala Thr Val Tyr Glu Glu Gln Leu Gln Leu Glu Arg 
        435                 440                 445             


Ala Leu Gln Glu Ser Leu Gln Leu Ser Thr Glu Pro Arg Gly Pro Gly 
    450                 455                 460                 


Ser Pro Pro Arg Thr Pro Pro Ala Pro Gly Pro Pro Ser Phe Glu Glu 
465                 470                 475                 480 


Gln Leu Arg Leu Ala Leu Glu Leu Ser Ser Arg Glu Gln Glu Glu Arg 
                485                 490                 495     


Glu Arg Arg Gly Gln Gln Glu Glu Glu Asp Leu Gln Arg Ile Leu Gln 
            500                 505                 510         


Leu Ser Leu Thr Glu His 
        515             


<210>  2758
<211>  2808
<212>  DNA
<213>  Homosapiens

<400>  2758
gtccgtcctt cctggtcctg cgggtccagg actgtccgcg gggttgaggg aaggggccgt     60

gcccggtgcc agcccaggtg ctcgcggcct ggctccatgg ccctggtcac agtgagccgt    120

tcgcccccgg gcagcggcgc ctccacgccc gtggggccct gggaccaggc ggtccagcga    180

aggagtcgac tccagcgaag gcagagcttt gcggtgctcc gtggggctgt cctgggactg    240

caggatggag gggacaatga tgatgcagca gaggccagtt ctgagccaac agagaaggcc    300

ccgagtgagg aggagctcca cggggaccag acagacttcg ggcaaggatc ccagagtccc    360

cagaagcagg aggagcagag gcagcacctg cacctcatgg tacagctgct gaggccgcag    420

gatgacatcc gcctggcagc ccagctggag gcaccccggc ctccccggct ccgctacctg    480

ctggtagttt ctacacgaga aggagaaggt ctgagccagg atgagacggt cctcctgggc    540

gtggatttcc ctgacagcag ctcccccagc tgcaccctgg gcctggtctt gcccctctgg    600

agtgacaccc aggtgtactt agatggagac gggggcttca gcgtgacgtc tggtgggcaa    660

agccggatct tcaagcccat ctccatccag accatgtggg ccacactcca ggtattgcac    720

caagcatgtg aggcagctct aggcagcggc cttgtaccgg gtggcagtgc cctcacctgg    780

gccagccact accaggagag actgaactcc gaacagagct gcctcaatga gtggacggct    840

atggccgacc tggagtctct gcggcctccc agcgccgagc ctggcgggtc ctcagaacag    900

gagcagatgg agcaggcgat ccgtgctgag ctgtggaaag tgttggatgt cagtgacctg    960

gagagtgtca cttccaaaga gatccgccag gctctggagc tgcgcctggg gctccccctc   1020

cagcagtacc gtgacttcat cgacaaccag atgctgctgc tggtggcaca gcgggaccga   1080

gcctcccgca tcttccccca cctctacctg ggctcagagt ggaacgcagc aaacctggag   1140

gagctgcaga ggaacagggt cacccacatc ttgaacatgg cccgggagat tgacaacttc   1200

taccctgagc gcttcaccta ccacaatgtg cgcctctggg atgaggagtc ggcccagctg   1260

ctgccgcact ggaaggagac gcaccgcttc attgaggctg caagagcaca gggcacccac   1320

gtgctggtcc actgcaagat gggcgtcagc cgctcagcgg ccacagtgct ggcctatgcc   1380

atgaagcagt acgaatgcag cctggagcag gccctgcgcc acgtgcagga gctccggccc   1440

atcgcccgcc ccaaccctgg cttcctgcgc cagctgcaga tctaccaggg catcctgacg   1500

gccagccgcc agagccatgt ctgggagcag aaagtgggtg gggtctcccc agaggagcac   1560

ccagcccctg aagtctctac accattccca cctcttccgc cagaacctga gggtggtggg   1620

gaggagaagg ttgtaggcat ggaagagagc caggcagccc cgaaagaaga gcctgggcca   1680

cggccacgta taaacctccg aggggtcatg aggtccatca gtcttctgga gccctccttg   1740

gagctggaga gcacctcaga gaccagtgac atgccagagg tcttctcttc ccacgagtct   1800

tcacatgaag agcctctgca gcccttccca cagcttgcaa ggaccaaggg aggccagcag   1860

gtggacaggg ggcctcagcc tgccctgaag tcccgccagt cagtggttac cctccagggc   1920

agtgccgtgg tggccaaccg gacccaggcc ttccaggagc aggagcaggg gcaggggcag   1980

gggcagggag agccctgcat ttcctctacg cccaggtccc ggaaggtggt gagacaggcc   2040

agcgtgcatg acagtggaga ggagggcgag gcctgagccc tcacacatgc ccacgctccc   2100

ctgacactga agaggatcca caactccttg gagaaacacc ctcacgtctg ttgccgcaca   2160

cattcctctc agctccgccc catacccgtc actacagcct cacctcccac ccctgtcact   2220

acggcctcac ctcccacccc tgtcactaca gcctcacctc ctacagcctt aagtcccagg   2280

cccatgtctg cctgtccaag ggctcaagac tttctaactg ggatgtggta gagggactga   2340

aggtaccttt gggggcaaca gcaccctagt ttcattctca actctagccc tgcacactca   2400

cctgtggcac ggaatgaaaa cagagcttcc cgtgcaaaaa gggtcacgcc tcccaccccc   2460

gccccctccc tgcacctcct gtcctctccc agttcattcc tggaaccagc caggccaggc   2520

aaccagtggc ccccaaaggc aggcaggatc ctcaggcccc agccgcggga ggctggaagg   2580

gctggcagat cgcttccctc atccacctcc accggtccag gtctttgctg ctgtccccag   2640

acctcctgtg acaccacgcc agatcacagg gcaccaggcc agagatagtc ttctttttgt   2700

cctttctggc ctctggctag tcagtttttc atagccttac agtatctggc tttgtactga   2760

gaaataaaac acattttcat atttggttaa aaaaaaaaaa aaaaaaaa                2808


<210>  2759
<211>  659
<212>  PRT
<213>  Homosapiens

<400>  2759

Met Ala Leu Val Thr Val Ser Arg Ser Pro Pro Gly Ser Gly Ala Ser 
1               5                   10                  15      


Thr Pro Val Gly Pro Trp Asp Gln Ala Val Gln Arg Arg Ser Arg Leu 
            20                  25                  30          


Gln Arg Arg Gln Ser Phe Ala Val Leu Arg Gly Ala Val Leu Gly Leu 
        35                  40                  45              


Gln Asp Gly Gly Asp Asn Asp Asp Ala Ala Glu Ala Ser Ser Glu Pro 
    50                  55                  60                  


Thr Glu Lys Ala Pro Ser Glu Glu Glu Leu His Gly Asp Gln Thr Asp 
65                  70                  75                  80  


Phe Gly Gln Gly Ser Gln Ser Pro Gln Lys Gln Glu Glu Gln Arg Gln 
                85                  90                  95      


His Leu His Leu Met Val Gln Leu Leu Arg Pro Gln Asp Asp Ile Arg 
            100                 105                 110         


Leu Ala Ala Gln Leu Glu Ala Pro Arg Pro Pro Arg Leu Arg Tyr Leu 
        115                 120                 125             


Leu Val Val Ser Thr Arg Glu Gly Glu Gly Leu Ser Gln Asp Glu Thr 
    130                 135                 140                 


Val Leu Leu Gly Val Asp Phe Pro Asp Ser Ser Ser Pro Ser Cys Thr 
145                 150                 155                 160 


Leu Gly Leu Val Leu Pro Leu Trp Ser Asp Thr Gln Val Tyr Leu Asp 
                165                 170                 175     


Gly Asp Gly Gly Phe Ser Val Thr Ser Gly Gly Gln Ser Arg Ile Phe 
            180                 185                 190         


Lys Pro Ile Ser Ile Gln Thr Met Trp Ala Thr Leu Gln Val Leu His 
        195                 200                 205             


Gln Ala Cys Glu Ala Ala Leu Gly Ser Gly Leu Val Pro Gly Gly Ser 
    210                 215                 220                 


Ala Leu Thr Trp Ala Ser His Tyr Gln Glu Arg Leu Asn Ser Glu Gln 
225                 230                 235                 240 


Ser Cys Leu Asn Glu Trp Thr Ala Met Ala Asp Leu Glu Ser Leu Arg 
                245                 250                 255     


Pro Pro Ser Ala Glu Pro Gly Gly Ser Ser Glu Gln Glu Gln Met Glu 
            260                 265                 270         


Gln Ala Ile Arg Ala Glu Leu Trp Lys Val Leu Asp Val Ser Asp Leu 
        275                 280                 285             


Glu Ser Val Thr Ser Lys Glu Ile Arg Gln Ala Leu Glu Leu Arg Leu 
    290                 295                 300                 


Gly Leu Pro Leu Gln Gln Tyr Arg Asp Phe Ile Asp Asn Gln Met Leu 
305                 310                 315                 320 


Leu Leu Val Ala Gln Arg Asp Arg Ala Ser Arg Ile Phe Pro His Leu 
                325                 330                 335     


Tyr Leu Gly Ser Glu Trp Asn Ala Ala Asn Leu Glu Glu Leu Gln Arg 
            340                 345                 350         


Asn Arg Val Thr His Ile Leu Asn Met Ala Arg Glu Ile Asp Asn Phe 
        355                 360                 365             


Tyr Pro Glu Arg Phe Thr Tyr His Asn Val Arg Leu Trp Asp Glu Glu 
    370                 375                 380                 


Ser Ala Gln Leu Leu Pro His Trp Lys Glu Thr His Arg Phe Ile Glu 
385                 390                 395                 400 


Ala Ala Arg Ala Gln Gly Thr His Val Leu Val His Cys Lys Met Gly 
                405                 410                 415     


Val Ser Arg Ser Ala Ala Thr Val Leu Ala Tyr Ala Met Lys Gln Tyr 
            420                 425                 430         


Glu Cys Ser Leu Glu Gln Ala Leu Arg His Val Gln Glu Leu Arg Pro 
        435                 440                 445             


Ile Ala Arg Pro Asn Pro Gly Phe Leu Arg Gln Leu Gln Ile Tyr Gln 
    450                 455                 460                 


Gly Ile Leu Thr Ala Ser Arg Gln Ser His Val Trp Glu Gln Lys Val 
465                 470                 475                 480 


Gly Gly Val Ser Pro Glu Glu His Pro Ala Pro Glu Val Ser Thr Pro 
                485                 490                 495     


Phe Pro Pro Leu Pro Pro Glu Pro Glu Gly Gly Gly Glu Glu Lys Val 
            500                 505                 510         


Val Gly Met Glu Glu Ser Gln Ala Ala Pro Lys Glu Glu Pro Gly Pro 
        515                 520                 525             


Arg Pro Arg Ile Asn Leu Arg Gly Val Met Arg Ser Ile Ser Leu Leu 
    530                 535                 540                 


Glu Pro Ser Leu Glu Leu Glu Ser Thr Ser Glu Thr Ser Asp Met Pro 
545                 550                 555                 560 


Glu Val Phe Ser Ser His Glu Ser Ser His Glu Glu Pro Leu Gln Pro 
                565                 570                 575     


Phe Pro Gln Leu Ala Arg Thr Lys Gly Gly Gln Gln Val Asp Arg Gly 
            580                 585                 590         


Pro Gln Pro Ala Leu Lys Ser Arg Gln Ser Val Val Thr Leu Gln Gly 
        595                 600                 605             


Ser Ala Val Val Ala Asn Arg Thr Gln Ala Phe Gln Glu Gln Glu Gln 
    610                 615                 620                 


Gly Gln Gly Gln Gly Gln Gly Glu Pro Cys Ile Ser Ser Thr Pro Arg 
625                 630                 635                 640 


Ser Arg Lys Val Val Arg Gln Ala Ser Val His Asp Ser Gly Glu Glu 
                645                 650                 655     


Gly Glu Ala 
            


<210>  2760
<211>  2604
<212>  DNA
<213>  Homosapiens

<400>  2760
atggccctgg tcacagtgag ccgttcgccc ccgggcagcg gcgcctccac gcccgtgggg     60

ccctgggacc aggcggtcca gcgaaggagt cgactccagc gaaggcagag ctttgcggtg    120

ctccgtgggg ctgtcctggg actgcaggat ggaggggaca atgatgatgc agtagaggcc    180

agttctgagc caacagagaa ggccccgagt gaggaggagc tccacgggga ccagacagac    240

ttcgggcaag gatcccagag tccccagaag caggaggagc agaggcagca cctgcacctc    300

atggtacagc tgctgaggcc gcaggatgac atccgcctgg cagcccagct ggaggcaccc    360

cggcctcccc ggctccgcta cctgctggta gtttctacac gagaaggaga aggtctgagc    420

caggatgaga cggtcctcct gggcgtggat ttccctgaca gcagctcccc cagctgcacc    480

ctgggcctgg tcttgcccct ctggagtgac acccaggtgt acttagatgg agacgggggc    540

ttcagcgtga cgtctggtgg gcaaagccgg atcttcaagc ccatctccat ccagaccatg    600

tgggccacac tccaggtatt gcaccaagca tgtgaggcag ctctaggcag cggccttgta    660

ccgggtggca gtgccctcac ctgggccagc cactaccagg agagactgaa ctccgaacag    720

agctgcctca atgagtggac ggctatggcc gacctggagt ctctgcggcc tcccagcgcc    780

gagcctggcg ggtcctcaga acaggagcag atggagcagg cgatccgtgc tgagctgtgg    840

aaagtgttgg atgtcagtga cctggagagt gtcacttcca aagagatccg ccaggctctg    900

gagctgcgcc tggggctccc cctccagcag taccgtgact tcatcgacaa ccagatgctg    960

ctgctggtgg cacagcggga ccgagcctcc cgcatcttcc cccacctcta cctgggctca   1020

gagtggaacg cagcaaacct ggaggagctg cagaggaaca gggtcaccca catcttgaac   1080

atggcccggg agattgacaa cttctaccct gagcgcttca cctaccacaa tgtgcgcctc   1140

tgggatgagg agtcggccca gctgctgccg cactggaagg agacgcaccg cttcattgag   1200

gctgcaagag cacagggcac ccacgtgctg gtccactgca agatgggcgt cagccgctca   1260

gcggccacag tgctggccta tgccatgaag cagtacgaat gcagcctgga gcaggccctg   1320

cgccacgtgc aggagctccg gcccatcgcc cgccccaacc ctggcttcct gcgccagctg   1380

cagatctacc agggcatcct gacggccaga acctgagggt ggtggggagg agaaggttgt   1440

aggcatggaa gagagccagg cagccccgaa agaagagcct gggccacggc cacgtataaa   1500

cctccgaggg gtcatgaggt ccatcagtct tctggagccc tccttggagc tggagagcac   1560

ctcagagacc agtgacatgc cagaggtctt ctcttcccac gagtcttcac atgaagagcc   1620

tctgcagccc ttcccacagc ttgcaaggac caagggaggc cagcaggtgg acagggggcc   1680

tcagcctgcc ctgaagtccc gccagtcagt ggttaccctc cagggcagtg ccgtggtggc   1740

caaccggacc caggccttcc aggagcagga gcaggggcag gggcaggggc agggagagcc   1800

ctgcatttcc tctacgccca ggttccggaa ggtggtgaga caggccagcg tgcatgacag   1860

tggagaggag ggcgaggcct gagccctcac acatgcccac gctcccctga cactgaagag   1920

gatccacaac tccttggaga aacaccctca cgtctgttgc cgcacacatt cctctcagct   1980

ccgccccata cccgtcacta cagcctcacc tcccacccct gtcactacgg cctcacctcc   2040

cacccctgtc actacagcct cacctcctac agccttaagt cccaggccca tgtctgcctg   2100

tccaagggct caagactttc taactgggat gtggtagagg gactgaaggt acctttgggg   2160

gcaacagcac cctagtttca ttctcaactc tagccctgca cactcacctg tggcacggaa   2220

tgaaaacaga gcttcccgtg caaaaagggt cacgcctccc acccccgccc cctccctgca   2280

cctcctgtcc tctcccagtt cattcctgga accagccagg ccaggcaacc agtggccccc   2340

aaaggcaggc aggatcctca ggccccagcc gcgggaggct ggaagggctg gcagatcgct   2400

tccctcatcc acctccaccg gtccaggtct ttgctgctgt ccccagacct cctgtgacac   2460

cacgccagat cacagggcac caggccagag atagtcttct ttttgtcctt tctggcctct   2520

ggctagtcag tttttcatag ccttacagta tctggctttg tactgagaaa taaaacacat   2580

tttcataaaa aaaaaaaaaa aaaa                                          2604


<210>  2761
<211>  471
<212>  PRT
<213>  Homosapiens

<400>  2761

Met Ala Leu Val Thr Val Ser Arg Ser Pro Pro Gly Ser Gly Ala Ser 
1               5                   10                  15      


Thr Pro Val Gly Pro Trp Asp Gln Ala Val Gln Arg Arg Ser Arg Leu 
            20                  25                  30          


Gln Arg Arg Gln Ser Phe Ala Val Leu Arg Gly Ala Val Leu Gly Leu 
        35                  40                  45              


Gln Asp Gly Gly Asp Asn Asp Asp Ala Val Glu Ala Ser Ser Glu Pro 
    50                  55                  60                  


Thr Glu Lys Ala Pro Ser Glu Glu Glu Leu His Gly Asp Gln Thr Asp 
65                  70                  75                  80  


Phe Gly Gln Gly Ser Gln Ser Pro Gln Lys Gln Glu Glu Gln Arg Gln 
                85                  90                  95      


His Leu His Leu Met Val Gln Leu Leu Arg Pro Gln Asp Asp Ile Arg 
            100                 105                 110         


Leu Ala Ala Gln Leu Glu Ala Pro Arg Pro Pro Arg Leu Arg Tyr Leu 
        115                 120                 125             


Leu Val Val Ser Thr Arg Glu Gly Glu Gly Leu Ser Gln Asp Glu Thr 
    130                 135                 140                 


Val Leu Leu Gly Val Asp Phe Pro Asp Ser Ser Ser Pro Ser Cys Thr 
145                 150                 155                 160 


Leu Gly Leu Val Leu Pro Leu Trp Ser Asp Thr Gln Val Tyr Leu Asp 
                165                 170                 175     


Gly Asp Gly Gly Phe Ser Val Thr Ser Gly Gly Gln Ser Arg Ile Phe 
            180                 185                 190         


Lys Pro Ile Ser Ile Gln Thr Met Trp Ala Thr Leu Gln Val Leu His 
        195                 200                 205             


Gln Ala Cys Glu Ala Ala Leu Gly Ser Gly Leu Val Pro Gly Gly Ser 
    210                 215                 220                 


Ala Leu Thr Trp Ala Ser His Tyr Gln Glu Arg Leu Asn Ser Glu Gln 
225                 230                 235                 240 


Ser Cys Leu Asn Glu Trp Thr Ala Met Ala Asp Leu Glu Ser Leu Arg 
                245                 250                 255     


Pro Pro Ser Ala Glu Pro Gly Gly Ser Ser Glu Gln Glu Gln Met Glu 
            260                 265                 270         


Gln Ala Ile Arg Ala Glu Leu Trp Lys Val Leu Asp Val Ser Asp Leu 
        275                 280                 285             


Glu Ser Val Thr Ser Lys Glu Ile Arg Gln Ala Leu Glu Leu Arg Leu 
    290                 295                 300                 


Gly Leu Pro Leu Gln Gln Tyr Arg Asp Phe Ile Asp Asn Gln Met Leu 
305                 310                 315                 320 


Leu Leu Val Ala Gln Arg Asp Arg Ala Ser Arg Ile Phe Pro His Leu 
                325                 330                 335     


Tyr Leu Gly Ser Glu Trp Asn Ala Ala Asn Leu Glu Glu Leu Gln Arg 
            340                 345                 350         


Asn Arg Val Thr His Ile Leu Asn Met Ala Arg Glu Ile Asp Asn Phe 
        355                 360                 365             


Tyr Pro Glu Arg Phe Thr Tyr His Asn Val Arg Leu Trp Asp Glu Glu 
    370                 375                 380                 


Ser Ala Gln Leu Leu Pro His Trp Lys Glu Thr His Arg Phe Ile Glu 
385                 390                 395                 400 


Ala Ala Arg Ala Gln Gly Thr His Val Leu Val His Cys Lys Met Gly 
                405                 410                 415     


Val Ser Arg Ser Ala Ala Thr Val Leu Ala Tyr Ala Met Lys Gln Tyr 
            420                 425                 430         


Glu Cys Ser Leu Glu Gln Ala Leu Arg His Val Gln Glu Leu Arg Pro 
        435                 440                 445             


Ile Ala Arg Pro Asn Pro Gly Phe Leu Arg Gln Leu Gln Ile Tyr Gln 
    450                 455                 460                 


Gly Ile Leu Thr Ala Arg Thr 
465                 470     


<210>  2762
<211>  946
<212>  DNA
<213>  Homosapiens

<400>  2762
ctctctcggt ttgtctgggt catcttgtct gcccgccgct ggcctggccc cgtctgtctc     60

tctcagcagc tgtctttctc gcgcccactg gccggtctct cctcttcccc gcagttgcct    120

ccttctctgc ctgcctgggt ggccgccatg ggccggaagc ggctcatcac tgattcctac    180

ccggttgtga agaggaggga ggggcccgct gggcacagca agggggagct ggcacccgag    240

ctaggggagg agccccagcc ccgcgacgag gaggaagcgg agctggagct gctgaggcag    300

tttgacctgg cctggcagta cgggccctgc accgggatca cacggctgca gcgctggtgt    360

cgggccaagc atatgggctt ggagcctccc ccagaggtgt ggcaggtgct gaagacccac    420

cccggagacc cccgcttcca gtgcagtctc tggcatctct atcccctatg aggcaccacg    480

taagacctcc tgcccttagc tctcttgctc accacccaag aacctcagga cagaagcgag    540

agcccattgc tcctgctcag ctcagcccgg ctgcggagga acccttggca ggcagaacct    600

ggaggtgtca gaggctcaac tcctccatct aaccagcagg ctcccagagt ccccggaaga    660

gcctgcgcag ctgaagcaga gtgcttctag atggagagtg gtcactgggg aaaaggacct    720

ggccatcacc ttccaatacc tgctgcctgt ctccctgacc catgatctgg caagttaggc    780

acagtcagac atggacagtt gatccatgag gaaaagatgc tctcccacct aaggccagga    840

atctgagagc aggactggct gagctcccag ggcaaggggt tcactaatgc ttatcaataa    900

agaatattga gcctggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                   946


<210>  2763
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  2763

Met Gly Arg Lys Arg Leu Ile Thr Asp Ser Tyr Pro Val Val Lys Arg 
1               5                   10                  15      


Arg Glu Gly Pro Ala Gly His Ser Lys Gly Glu Leu Ala Pro Glu Leu 
            20                  25                  30          


Gly Glu Glu Pro Gln Pro Arg Asp Glu Glu Glu Ala Glu Leu Glu Leu 
        35                  40                  45              


Leu Arg Gln Phe Asp Leu Ala Trp Gln Tyr Gly Pro Cys Thr Gly Ile 
    50                  55                  60                  


Thr Arg Leu Gln Arg Trp Cys Arg Ala Lys His Met Gly Leu Glu Pro 
65                  70                  75                  80  


Pro Pro Glu Val Trp Gln Val Leu Lys Thr His Pro Gly Asp Pro Arg 
                85                  90                  95      


Phe Gln Cys Ser Leu Trp His Leu Tyr Pro Leu 
            100                 105         


<210>  2764
<211>  1860
<212>  DNA
<213>  Homosapiens

<400>  2764
acgtcagaaa aaaaaaaaaa aagtttgcag aatgtcccac accgaaaaaa aaaaaaaatc     60

cgaaaccgag cgaaaaaaac ctgcgagtgg gcctggcgga tgggattatt aaagcttcgc    120

cggagccgcg gctcgccctc ccactccgcc agcctccggg agaggagccg cacccggccg    180

gcccggcccc agccccatgg acctccgagc aggggactcg tgggggatgt tagcgtgcct    240

gtgcacggtg ctctggcacc tccctgcagt gccagctctc aatcgcacag gggacccagg    300

gcctggcccc tccatccaga aaacctatga cctcacccgc tacctggagc accaactccg    360

cagcttggct gggacctatc tgaactacct gggcccccct ttcaacgagc cagacttcaa    420

ccctccccgc ctgggggcag agactctgcc cagggccact gttgacttgg aggtgtggcg    480

aagcctcaat gacaaactgc ggctgaccca gaactacgag gcctacagcc accttctgtg    540

ttacttgcgt ggcctcaacc gtcaggctgc cactgctgag ctgcgccgca gcctggccca    600

cttctgcacc agcctccagg gcctgctggg cagcattgcg ggcgtcatgg cagctctggg    660

ctacccactg ccccagccgc tgcctgggac tgaacccact tggactcctg gccctgccca    720

cagtgacttc ctccagaaga tggacgactt ctggctgctg aaggagctgc agacctggct    780

gtggcgctcg gccaaggact tcaaccggct caagaagaag atgcagcctc cagcagctgc    840

agtcaccctg cacctggggg ctcatggctt ctgacttctg accttctcct cttcgctccc    900

ccttcaaacc ctgctcccac tttgtgagag ccagccctgt atgccaacac ctgttgagcc    960

aggagacaga agctgtgagc ctctggccct ttcctggacc ggctgggcgt gtgatgcgat   1020

cagccctgtc tcctccccac ctcccaaagg tctaccgagc tggggaggag gtacagtagg   1080

ccctgtcctg tcctgtttct acaggaagtc atgctcgagg gagtgtgaag tggttcaggt   1140

tggtgcagag gcgctcatgg cctcctgctt cttgcctacc acttggccag tgcccaccca   1200

gcccctcagg tggcacatct ggagggcagg ggttgagggg ccaccaccac acatgccttt   1260

ctggggtgaa gccctttggc tgccccactc tccttggatg ggtgttgctc ccttatcccc   1320

aaatcactct atacatccaa ttcaggaaac aaacatggtg gcaattctac acaaaaagag   1380

atgagattaa cagtgcaggg ttggggtctg cattggaggt gccctataaa ccagaagaga   1440

aaatactgaa agcacagggg cagggacaga ccagaccaga cccaggagtc tccaaagcac   1500

agagtggcaa acaaaacccg agctgagcat caggaccttg cctcgaattg tcttccagta   1560

ttacggtgcc tcttctctgc cccctttccc agggtatctg tgggttgcca ggctggggag   1620

ggcaaccata gccacaccac aggatttcct gaaagtttac aatgcagtag cattttgggg   1680

tgtagggtgg cagctcccca aggccctgcc ccccagcccc acccactcat gactctaagt   1740

gtgttgtatt aatatttatt tatttggaga tgttatttat tagatgatat ttattgcaga   1800

atttctattc ttgtattaac aaataaaatg cttgccccag aaaaaaaaaa aaaaaaaaaa   1860


<210>  2765
<211>  225
<212>  PRT
<213>  Homosapiens

<400>  2765

Met Asp Leu Arg Ala Gly Asp Ser Trp Gly Met Leu Ala Cys Leu Cys 
1               5                   10                  15      


Thr Val Leu Trp His Leu Pro Ala Val Pro Ala Leu Asn Arg Thr Gly 
            20                  25                  30          


Asp Pro Gly Pro Gly Pro Ser Ile Gln Lys Thr Tyr Asp Leu Thr Arg 
        35                  40                  45              


Tyr Leu Glu His Gln Leu Arg Ser Leu Ala Gly Thr Tyr Leu Asn Tyr 
    50                  55                  60                  


Leu Gly Pro Pro Phe Asn Glu Pro Asp Phe Asn Pro Pro Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Thr Leu Pro Arg Ala Thr Val Asp Leu Glu Val Trp Arg Ser 
                85                  90                  95      


Leu Asn Asp Lys Leu Arg Leu Thr Gln Asn Tyr Glu Ala Tyr Ser His 
            100                 105                 110         


Leu Leu Cys Tyr Leu Arg Gly Leu Asn Arg Gln Ala Ala Thr Ala Glu 
        115                 120                 125             


Leu Arg Arg Ser Leu Ala His Phe Cys Thr Ser Leu Gln Gly Leu Leu 
    130                 135                 140                 


Gly Ser Ile Ala Gly Val Met Ala Ala Leu Gly Tyr Pro Leu Pro Gln 
145                 150                 155                 160 


Pro Leu Pro Gly Thr Glu Pro Thr Trp Thr Pro Gly Pro Ala His Ser 
                165                 170                 175     


Asp Phe Leu Gln Lys Met Asp Asp Phe Trp Leu Leu Lys Glu Leu Gln 
            180                 185                 190         


Thr Trp Leu Trp Arg Ser Ala Lys Asp Phe Asn Arg Leu Lys Lys Lys 
        195                 200                 205             


Met Gln Pro Pro Ala Ala Ala Val Thr Leu His Leu Gly Ala His Gly 
    210                 215                 220                 


Phe 
225 


<210>  2766
<211>  2128
<212>  DNA
<213>  Homosapiens

<400>  2766
gggccggcag gggcggtgcg cgggaaggga ccccggaccc ggaggtcgcg gagagctggg     60

cagtgttggc cgctggcgga gcgctggggc agcatgaagt gcctggtcac gggcggcaac    120

gtgaaggtgc tcggcaaggc cgtccactcc ctgtcccgca tcggggacga gctctacctg    180

gaacccttgg aggacgggct ctccctccgg acggtgaact cctcccgctc tgcctatgcc    240

tgctttctct ttgccccgct cttcttccag caataccagg cagccacccc tggtcaggac    300

ctgctgcgct gtaagatcct gatgaagtct ttcctgtctg tcttccgctc actggcgatg    360

ctggagaaga cggtggaaaa atgctgcatc tccctgaatg gccggagcag ccgcctggtg    420

gtccagctgc attgcaagtt cggggtgcgg aagactcaca acctgtcctt ccaggactgt    480

gagtccctgc aggccgtctt cgacccagcc tcgtgccccc acatgctccg cgccccagca    540

cgggttctgg gggaggctgt tctgcccttc tctcctgcac tggctgaagt gacgctgggc    600

attggccgtg gccgcagggt catcctgcgc agctaccacg aggaggaggc agacagcact    660

gccaaagcca tggtgactga gatgtgcctt ggagaggagg atttccagca gctgcaggcc    720

caggaagggg tggccatcac tttctgcctc aaggaattcc gggggctcct gagctttgca    780

gagtcagcaa acttgaatct tagcattcat tttgatgctc caggcaggcc cgccatcttc    840

accatcaagg actctttgct ggacggccac tttgtcttgg ccacactctc agacaccgac    900

tcgcactccc aggacctggg ctccccagag cgtcaccagc cagtgcctca gctccaggct    960

cacagcacac cccacccgga cgactttgcc aatgacgaca ttgactctta catgatcgcc   1020

atggaaacca ctataggcaa tgagggctcg cgggtgctgc cctccatttc cctttcacct   1080

ggcccccagc cccccaagag ccccggtccc cactccgagg aggaagatga ggctgagccc   1140

agtacagtgc ctgggactcc cccacccaag aagttccgct cactgttctt cggctccatc   1200

ctggcccctg tacgctcccc ccagggcccc agccctgtgc tggcggaaga cagtgagggt   1260

gaaggctgaa ccaagaacct gaagcctgta cccagaggcc ttggactaga cgaagcccca   1320

gccagtggca gaactgggtc tctcagccct ggggatcaga aaggtgggct tgctggagct   1380

gagctgtttc actgcctctc gcaggcccca gctggctgtc actgtaaagc tgtcccacag   1440

cggtcgggcc tgggccgtta tctccccaca acccccagcc aatcaggact ttccagactt   1500

ggccctgaac tactgacgtt cctacctctt atttctcatt gagcctcagg ctatactcca   1560

gctggccaag gctggaaacc tgtctccctc aggctcacct tcctaaggaa aatgtcatag   1620

taggtgctgc tggcccctgg tgatccagct tctctgccaa tcatgacctg ttccttcctg   1680

aagtcctggg catgcatctg ggacccccgt ggagctgaca agttttcctt gctttcctga   1740

tactctttgg cgctgacttg gaattctaag agccttggac ccgagtgtgt ggctagggtt   1800

gccctggctg gggcccggtg ccgagactcc caagcggctc tgtgcagaag agctgccagg   1860

cagtgtctta gatgtgagac ggaggccatg gcgagaatcc agctttgacc tttattcaag   1920

agaccagatg ggttgcccca ggatccggct gccagccctg aggccaagca cggctggaga   1980

cccacgacct ggcctgccgt tgccctgagc tgcagcctcg gccccaggat cctgctcaca   2040

gtcaccgcag gtgcaggcag gaagcagccc tgggggactg gacgctgcta ttgattcatt   2100

aaaaaaagaa aagaaaaata caaaaaaa                                      2128


<210>  2767
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  2767

Met Lys Cys Leu Val Thr Gly Gly Asn Val Lys Val Leu Gly Lys Ala 
1               5                   10                  15      


Val His Ser Leu Ser Arg Ile Gly Asp Glu Leu Tyr Leu Glu Pro Leu 
            20                  25                  30          


Glu Asp Gly Leu Ser Leu Arg Thr Val Asn Ser Ser Arg Ser Ala Tyr 
        35                  40                  45              


Ala Cys Phe Leu Phe Ala Pro Leu Phe Phe Gln Gln Tyr Gln Ala Ala 
    50                  55                  60                  


Thr Pro Gly Gln Asp Leu Leu Arg Cys Lys Ile Leu Met Lys Ser Phe 
65                  70                  75                  80  


Leu Ser Val Phe Arg Ser Leu Ala Met Leu Glu Lys Thr Val Glu Lys 
                85                  90                  95      


Cys Cys Ile Ser Leu Asn Gly Arg Ser Ser Arg Leu Val Val Gln Leu 
            100                 105                 110         


His Cys Lys Phe Gly Val Arg Lys Thr His Asn Leu Ser Phe Gln Asp 
        115                 120                 125             


Cys Glu Ser Leu Gln Ala Val Phe Asp Pro Ala Ser Cys Pro His Met 
    130                 135                 140                 


Leu Arg Ala Pro Ala Arg Val Leu Gly Glu Ala Val Leu Pro Phe Ser 
145                 150                 155                 160 


Pro Ala Leu Ala Glu Val Thr Leu Gly Ile Gly Arg Gly Arg Arg Val 
                165                 170                 175     


Ile Leu Arg Ser Tyr His Glu Glu Glu Ala Asp Ser Thr Ala Lys Ala 
            180                 185                 190         


Met Val Thr Glu Met Cys Leu Gly Glu Glu Asp Phe Gln Gln Leu Gln 
        195                 200                 205             


Ala Gln Glu Gly Val Ala Ile Thr Phe Cys Leu Lys Glu Phe Arg Gly 
    210                 215                 220                 


Leu Leu Ser Phe Ala Glu Ser Ala Asn Leu Asn Leu Ser Ile His Phe 
225                 230                 235                 240 


Asp Ala Pro Gly Arg Pro Ala Ile Phe Thr Ile Lys Asp Ser Leu Leu 
                245                 250                 255     


Asp Gly His Phe Val Leu Ala Thr Leu Ser Asp Thr Asp Ser His Ser 
            260                 265                 270         


Gln Asp Leu Gly Ser Pro Glu Arg His Gln Pro Val Pro Gln Leu Gln 
        275                 280                 285             


Ala His Ser Thr Pro His Pro Asp Asp Phe Ala Asn Asp Asp Ile Asp 
    290                 295                 300                 


Ser Tyr Met Ile Ala Met Glu Thr Thr Ile Gly Asn Glu Gly Ser Arg 
305                 310                 315                 320 


Val Leu Pro Ser Ile Ser Leu Ser Pro Gly Pro Gln Pro Pro Lys Ser 
                325                 330                 335     


Pro Gly Pro His Ser Glu Glu Glu Asp Glu Ala Glu Pro Ser Thr Val 
            340                 345                 350         


Pro Gly Thr Pro Pro Pro Lys Lys Phe Arg Ser Leu Phe Phe Gly Ser 
        355                 360                 365             


Ile Leu Ala Pro Val Arg Ser Pro Gln Gly Pro Ser Pro Val Leu Ala 
    370                 375                 380                 


Glu Asp Ser Glu Gly Glu Gly 
385                 390     


<210>  2768
<211>  1521
<212>  DNA
<213>  Homosapiens

<400>  2768
gcggggccgc gggccggggg cggactgggg cgggcggaag gagagccagg ccggaaggag     60

gctgccggag ggcgggaggc aggagcgggc caggagctgc tgggctggag cggcggcgcc    120

gccatgtccg acagcgagaa gctcaacctg gactcgatca tcgggcgcct gctggaaggg    180

tccagggtcc tgacacccca ttgcgcccca gtgcagggct cgcggcctgg caagaatgta    240

cagctgacag agaacgagat ccgcggtctg tgcctgaaat cccgggagat ttttctgagc    300

cagcccattc ttctggagct ggaggcaccc ctcaagatct gcggtgacat acacggccag    360

tactacgacc ttctgcgact atttgagtat ggcggtttcc ctcccgagag caactacctc    420

tttctggggg actatgtgga caggggcaag cagtccttgg agaccatctg cctgctgctg    480

gcctataaga tcaagtaccc cgagaacttc ttcctgctcc gtgggaacca cgagtgtgcc    540

agcatcaacc gcatctatgg tttctacgat gagtgcaaga gacgctacaa catcaaactg    600

tggaaaacct tcactgactg cttcaactgc ctgcccatcg cggccatagt ggacgaaaag    660

atcttctgct gccacggagg cctgtccccg gacctgcagt ctatggagca gattcggcgg    720

atcatgcggc ccacagatgt gcctgaccag ggcctgctgt gtgacctgct gtggtctgac    780

cctgacaagg acgtgcaggg ctggggcgag aacgaccgtg gcgtctcttt tacctttgga    840

gccgaggtgg tggccaagtt cctccacaag cacgacttgg acctcatctg ccgagcacac    900

caggtggtag aagacggcta cgagttcttt gccaagcggc agctggtgac acttttctca    960

gctcccaact actgtggcga gtttgacaat gctggcgcca tgatgagtgt ggacgagacc   1020

ctcatgtgct ctttccagat cctcaagccc gccgacaaga acaaggggaa gtacgggcag   1080

ttcagtggcc tgaaccctgg aggccgaccc atcaccccac cccgcaattc cgccaaagcc   1140

aagaaatagc ccccgcacac caccctgtgc cccagatgat ggattgattg tacagaaatc   1200

atgctgccat gctggggggg ggtcaccccg acccctcagg cccacctgtc acggggaaca   1260

tggagccttg gtgtattttt cttttctttt tttaatgaat caatagcagc gtccagtccc   1320

ccagggctgc ttcctgcctg cacctgcggt gactgtgagc aggatcctgg ggccgaggct   1380

gcagctcagg gcaacggcag gccaggtcgt gggtctccag ccgtgcttgg cctcagggct   1440

ggcagccgga tcctggggca acccatctgg tctcttgaat aaaggtcaaa gctggattct   1500

cgcaaaaaaa aaaaaaaaaa a                                             1521


<210>  2769
<211>  341
<212>  PRT
<213>  Homosapiens

<400>  2769

Met Ser Asp Ser Glu Lys Leu Asn Leu Asp Ser Ile Ile Gly Arg Leu 
1               5                   10                  15      


Leu Glu Gly Ser Arg Val Leu Thr Pro His Cys Ala Pro Val Gln Gly 
            20                  25                  30          


Ser Arg Pro Gly Lys Asn Val Gln Leu Thr Glu Asn Glu Ile Arg Gly 
        35                  40                  45              


Leu Cys Leu Lys Ser Arg Glu Ile Phe Leu Ser Gln Pro Ile Leu Leu 
    50                  55                  60                  


Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile His Gly Gln Tyr 
65                  70                  75                  80  


Tyr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe Pro Pro Glu Ser 
                85                  90                  95      


Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly Lys Gln Ser Leu 
            100                 105                 110         


Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys Tyr Pro Glu Asn 
        115                 120                 125             


Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser Ile Asn Arg Ile 
    130                 135                 140                 


Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Tyr Asn Ile Lys Leu Trp 
145                 150                 155                 160 


Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile Ala Ala Ile Val 
                165                 170                 175     


Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser Pro Asp Leu Gln 
            180                 185                 190         


Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr Asp Val Pro Asp 
        195                 200                 205             


Gln Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro Asp Lys Asp Val 
    210                 215                 220                 


Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe Thr Phe Gly Ala 
225                 230                 235                 240 


Glu Val Val Ala Lys Phe Leu His Lys His Asp Leu Asp Leu Ile Cys 
                245                 250                 255     


Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe Phe Ala Lys Arg 
            260                 265                 270         


Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys Gly Glu Phe Asp 
        275                 280                 285             


Asn Ala Gly Ala Met Met Ser Val Asp Glu Thr Leu Met Cys Ser Phe 
    290                 295                 300                 


Gln Ile Leu Lys Pro Ala Asp Lys Asn Lys Gly Lys Tyr Gly Gln Phe 
305                 310                 315                 320 


Ser Gly Leu Asn Pro Gly Gly Arg Pro Ile Thr Pro Pro Arg Asn Ser 
                325                 330                 335     


Ala Lys Ala Lys Lys 
            340     


<210>  2770
<211>  1488
<212>  DNA
<213>  Homosapiens

<400>  2770
gcggggccgc gggccggggg cggactgggg cgggcggaag gagagccagg ccggaaggag     60

gctgccggag ggcgggaggc aggagcgggc caggagctgc tgggctggag cggcggcgcc    120

gccatgtccg acagcgagaa gctcaacctg gactcgatca tcgggcgcct gctggaagtg    180

cagggctcgc ggcctggcaa gaatgtacag ctgacagaga acgagatccg cggtctgtgc    240

ctgaaatccc gggagatttt tctgagccag cccattcttc tggagctgga ggcacccctc    300

aagatctgcg gtgacataca cggccagtac tacgaccttc tgcgactatt tgagtatggc    360

ggtttccctc ccgagagcaa ctacctcttt ctgggggact atgtggacag gggcaagcag    420

tccttggaga ccatctgcct gctgctggcc tataagatca agtaccccga gaacttcttc    480

ctgctccgtg ggaaccacga gtgtgccagc atcaaccgca tctatggttt ctacgatgag    540

tgcaagagac gctacaacat caaactgtgg aaaaccttca ctgactgctt caactgcctg    600

cccatcgcgg ccatagtgga cgaaaagatc ttctgctgcc acggaggcct gtccccggac    660

ctgcagtcta tggagcagat tcggcggatc atgcggccca cagatgtgcc tgaccagggc    720

ctgctgtgtg acctgctgtg gtctgaccct gacaaggacg tgcagggctg gggcgagaac    780

gaccgtggcg tctcttttac ctttggagcc gaggtggtgg ccaagttcct ccacaagcac    840

gacttggacc tcatctgccg agcacaccag gtggtagaag acggctacga gttctttgcc    900

aagcggcagc tggtgacact tttctcagct cccaactact gtggcgagtt tgacaatgct    960

ggcgccatga tgagtgtgga cgagaccctc atgtgctctt tccagatcct caagcccgcc   1020

gacaagaaca aggggaagta cgggcagttc agtggcctga accctggagg ccgacccatc   1080

accccacccc gcaattccgc caaagccaag aaatagcccc cgcacaccac cctgtgcccc   1140

agatgatgga ttgattgtac agaaatcatg ctgccatgct gggggggggt caccccgacc   1200

cctcaggccc acctgtcacg gggaacatgg agccttggtg tatttttctt ttcttttttt   1260

aatgaatcaa tagcagcgtc cagtccccca gggctgcttc ctgcctgcac ctgcggtgac   1320

tgtgagcagg atcctggggc cgaggctgca gctcagggca acggcaggcc aggtcgtggg   1380

tctccagccg tgcttggcct cagggctggc agccggatcc tggggcaacc catctggtct   1440

cttgaataaa ggtcaaagct ggattctcgc aaaaaaaaaa aaaaaaaa                1488


<210>  2771
<211>  330
<212>  PRT
<213>  Homosapiens

<400>  2771

Met Ser Asp Ser Glu Lys Leu Asn Leu Asp Ser Ile Ile Gly Arg Leu 
1               5                   10                  15      


Leu Glu Val Gln Gly Ser Arg Pro Gly Lys Asn Val Gln Leu Thr Glu 
            20                  25                  30          


Asn Glu Ile Arg Gly Leu Cys Leu Lys Ser Arg Glu Ile Phe Leu Ser 
        35                  40                  45              


Gln Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp 
    50                  55                  60                  


Ile His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly 
65                  70                  75                  80  


Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg 
                85                  90                  95      


Gly Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile 
            100                 105                 110         


Lys Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala 
        115                 120                 125             


Ser Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Tyr 
    130                 135                 140                 


Asn Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro 
145                 150                 155                 160 


Ile Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu 
                165                 170                 175     


Ser Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro 
            180                 185                 190         


Thr Asp Val Pro Asp Gln Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp 
        195                 200                 205             


Pro Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser 
    210                 215                 220                 


Phe Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu His Lys His Asp 
225                 230                 235                 240 


Leu Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu 
                245                 250                 255     


Phe Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr 
            260                 265                 270         


Cys Gly Glu Phe Asp Asn Ala Gly Ala Met Met Ser Val Asp Glu Thr 
        275                 280                 285             


Leu Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Asp Lys Asn Lys Gly 
    290                 295                 300                 


Lys Tyr Gly Gln Phe Ser Gly Leu Asn Pro Gly Gly Arg Pro Ile Thr 
305                 310                 315                 320 


Pro Pro Arg Asn Ser Ala Lys Ala Lys Lys 
                325                 330 


<210>  2772
<211>  1356
<212>  DNA
<213>  Homosapiens

<400>  2772
gcggggccgc gggccggggg cggactgggg cgggcggaag gagagccagg ccggaaggag     60

gctgccggag ggcgggaggc aggagcgggc caggagctgc tgggctggag cggcggcgcc    120

gccatgtccg acagcgagaa gctcaacctg gactcgatca tcgggcgcct gctggaaggt    180

gacatacacg gccagtacta cgaccttctg cgactatttg agtatggcgg tttccctccc    240

gagagcaact acctctttct gggggactat gtggacaggg gcaagcagtc cttggagacc    300

atctgcctgc tgctggccta taagatcaag taccccgaga acttcttcct gctccgtggg    360

aaccacgagt gtgccagcat caaccgcatc tatggtttct acgatgagtg caagagacgc    420

tacaacatca aactgtggaa aaccttcact gactgcttca actgcctgcc catcgcggcc    480

atagtggacg aaaagatctt ctgctgccac ggaggcctgt ccccggacct gcagtctatg    540

gagcagattc ggcggatcat gcggcccaca gatgtgcctg accagggcct gctgtgtgac    600

ctgctgtggt ctgaccctga caaggacgtg cagggctggg gcgagaacga ccgtggcgtc    660

tcttttacct ttggagccga ggtggtggcc aagttcctcc acaagcacga cttggacctc    720

atctgccgag cacaccaggt ggtagaagac ggctacgagt tctttgccaa gcggcagctg    780

gtgacacttt tctcagctcc caactactgt ggcgagtttg acaatgctgg cgccatgatg    840

agtgtggacg agaccctcat gtgctctttc cagatcctca agcccgccga caagaacaag    900

gggaagtacg ggcagttcag tggcctgaac cctggaggcc gacccatcac cccaccccgc    960

aattccgcca aagccaagaa atagcccccg cacaccaccc tgtgccccag atgatggatt   1020

gattgtacag aaatcatgct gccatgctgg gggggggtca ccccgacccc tcaggcccac   1080

ctgtcacggg gaacatggag ccttggtgta tttttctttt ctttttttaa tgaatcaata   1140

gcagcgtcca gtcccccagg gctgcttcct gcctgcacct gcggtgactg tgagcaggat   1200

cctggggccg aggctgcagc tcagggcaac ggcaggccag gtcgtgggtc tccagccgtg   1260

cttggcctca gggctggcag ccggatcctg gggcaaccca tctggtctct tgaataaagg   1320

tcaaagctgg attctcgcaa aaaaaaaaaa aaaaaa                             1356


<210>  2773
<211>  286
<212>  PRT
<213>  Homosapiens

<400>  2773

Met Ser Asp Ser Glu Lys Leu Asn Leu Asp Ser Ile Ile Gly Arg Leu 
1               5                   10                  15      


Leu Glu Gly Asp Ile His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe 
            20                  25                  30          


Glu Tyr Gly Gly Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp 
        35                  40                  45              


Tyr Val Asp Arg Gly Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu 
    50                  55                  60                  


Ala Tyr Lys Ile Lys Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn 
65                  70                  75                  80  


His Glu Cys Ala Ser Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys 
                85                  90                  95      


Lys Arg Arg Tyr Asn Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe 
            100                 105                 110         


Asn Cys Leu Pro Ile Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys 
        115                 120                 125             


His Gly Gly Leu Ser Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg 
    130                 135                 140                 


Ile Met Arg Pro Thr Asp Val Pro Asp Gln Gly Leu Leu Cys Asp Leu 
145                 150                 155                 160 


Leu Trp Ser Asp Pro Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp 
                165                 170                 175     


Arg Gly Val Ser Phe Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu 
            180                 185                 190         


His Lys His Asp Leu Asp Leu Ile Cys Arg Ala His Gln Val Val Glu 
        195                 200                 205             


Asp Gly Tyr Glu Phe Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser 
    210                 215                 220                 


Ala Pro Asn Tyr Cys Gly Glu Phe Asp Asn Ala Gly Ala Met Met Ser 
225                 230                 235                 240 


Val Asp Glu Thr Leu Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Asp 
                245                 250                 255     


Lys Asn Lys Gly Lys Tyr Gly Gln Phe Ser Gly Leu Asn Pro Gly Gly 
            260                 265                 270         


Arg Pro Ile Thr Pro Pro Arg Asn Ser Ala Lys Ala Lys Lys 
        275                 280                 285     


<210>  2774
<211>  1766
<212>  DNA
<213>  Homosapiens

<400>  2774
gtgaggtgct gcgggaggcc ccgggcacca tggcccaggc cctgggggag gacctggtgc     60

agcctcccga gctgcaggat gactccagct ccttggggtc cgactcagag ctcagcgggc    120

ctggcccata tcgccaggcc gaccgctatg gattcattgg gggcagctca gcagagccag    180

ggccgggcca cccacctgca gacctcatcc gccaacggga gatgaagtgg gtggagatga    240

cctcgcactg ggagaaaacc atgtcccggc ggtacaagaa ggtaaagatg cagtgccgga    300

aaggcatccc gtctgccctg cgcgcccgat gctggcccct gttgtgtggg gcccatgtgt    360

gccagaagaa cagccctggc acctatcagg agctggcaga ggcccctgga gacccacagt    420

ggatggagac cattggcagg gacctgcacc gtcaattccc tctgcacgag atgtttgtgt    480

cgcctcaggg ccacgggcag caggggctcc tgcaggtgct caaggcctac accctgtatc    540

gaccggagca gggctactgc caggcccagg ggcccgtggc tgctgtgctg ctcatgcacc    600

tgcccccaga ggaggccttc tggtgcctgg tgcagatctg tgaggtctac ctccctgggt    660

actacgggcc ccacatggag gctgtgcggc tggacgccga ggtgttcatg gccctgctgc    720

ggcggctgct tccgcacgtg cacaagcacc tgcagcaggt gggcgtcgga cccctgctgt    780

acctgcccga gtggttcctg tgcctcttcg cccgctccct gcccttcccc acagtgctgc    840

gtgtctggga tgccttcctc agtgagggtg ccagagtact gttccgtgtg gggctgacac    900

tggtgcgcct ggcgctgggc actgcagagc agcgaggggc ctgccctggc ctcctggaga    960

cactgggagc ccttcgagcc atcccccccg cgcagctgca ggaggaggcc ttcatgtcac   1020

aggtgcacag cgtggtgctg tcagagcggg acctgcagcg ggagatcaag gcccagctgg   1080

cccagctgcc cgattccgcg ccgggacccc cgccccggcc acaggtccgc ctcgccgggg   1140

cccaagccat ctttgaggcc cagcagctgg caggagtgcg acgaggcgcc aagcctgagg   1200

tgcctcggat tgtggtgcag cccccggagg agcccagacc accgcggcgg aaaccccaga   1260

cccgcggcaa gactttccat gggctcctga ctcgggcccg gggccccccc atcgaggggc   1320

cccccaggcc ccaacgaggc tccacctcct tcctggacac ccgcttctga gaggaccatg   1380

gacttagtgt cccccagtct caattgcctg atggctgatg ccagcccggc aaataggcac   1440

cgcactttac tcttgggact cggggacttg gcttccttcc tggcaaggac caggcagtgg   1500

ggaaggagga ggtcctccgt ggtacatact gggtcaggca ctagcatgga ggagggtcac   1560

agagtggggc acgtgaggac ccatggaacc gtcctggtgc ccaggccctc acaagtacca   1620

aagccagcac caaaggagtc agggaagggg ttggctgagt caagggaccc cagagggcac   1680

caggaataaa atcttcttga acagaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1740

aaaaaaaaaa aaaaaaaaaa aaaaaa                                        1766


<210>  2775
<211>  446
<212>  PRT
<213>  Homosapiens

<400>  2775

Met Ala Gln Ala Leu Gly Glu Asp Leu Val Gln Pro Pro Glu Leu Gln 
1               5                   10                  15      


Asp Asp Ser Ser Ser Leu Gly Ser Asp Ser Glu Leu Ser Gly Pro Gly 
            20                  25                  30          


Pro Tyr Arg Gln Ala Asp Arg Tyr Gly Phe Ile Gly Gly Ser Ser Ala 
        35                  40                  45              


Glu Pro Gly Pro Gly His Pro Pro Ala Asp Leu Ile Arg Gln Arg Glu 
    50                  55                  60                  


Met Lys Trp Val Glu Met Thr Ser His Trp Glu Lys Thr Met Ser Arg 
65                  70                  75                  80  


Arg Tyr Lys Lys Val Lys Met Gln Cys Arg Lys Gly Ile Pro Ser Ala 
                85                  90                  95      


Leu Arg Ala Arg Cys Trp Pro Leu Leu Cys Gly Ala His Val Cys Gln 
            100                 105                 110         


Lys Asn Ser Pro Gly Thr Tyr Gln Glu Leu Ala Glu Ala Pro Gly Asp 
        115                 120                 125             


Pro Gln Trp Met Glu Thr Ile Gly Arg Asp Leu His Arg Gln Phe Pro 
    130                 135                 140                 


Leu His Glu Met Phe Val Ser Pro Gln Gly His Gly Gln Gln Gly Leu 
145                 150                 155                 160 


Leu Gln Val Leu Lys Ala Tyr Thr Leu Tyr Arg Pro Glu Gln Gly Tyr 
                165                 170                 175     


Cys Gln Ala Gln Gly Pro Val Ala Ala Val Leu Leu Met His Leu Pro 
            180                 185                 190         


Pro Glu Glu Ala Phe Trp Cys Leu Val Gln Ile Cys Glu Val Tyr Leu 
        195                 200                 205             


Pro Gly Tyr Tyr Gly Pro His Met Glu Ala Val Arg Leu Asp Ala Glu 
    210                 215                 220                 


Val Phe Met Ala Leu Leu Arg Arg Leu Leu Pro His Val His Lys His 
225                 230                 235                 240 


Leu Gln Gln Val Gly Val Gly Pro Leu Leu Tyr Leu Pro Glu Trp Phe 
                245                 250                 255     


Leu Cys Leu Phe Ala Arg Ser Leu Pro Phe Pro Thr Val Leu Arg Val 
            260                 265                 270         


Trp Asp Ala Phe Leu Ser Glu Gly Ala Arg Val Leu Phe Arg Val Gly 
        275                 280                 285             


Leu Thr Leu Val Arg Leu Ala Leu Gly Thr Ala Glu Gln Arg Gly Ala 
    290                 295                 300                 


Cys Pro Gly Leu Leu Glu Thr Leu Gly Ala Leu Arg Ala Ile Pro Pro 
305                 310                 315                 320 


Ala Gln Leu Gln Glu Glu Ala Phe Met Ser Gln Val His Ser Val Val 
                325                 330                 335     


Leu Ser Glu Arg Asp Leu Gln Arg Glu Ile Lys Ala Gln Leu Ala Gln 
            340                 345                 350         


Leu Pro Asp Ser Ala Pro Gly Pro Pro Pro Arg Pro Gln Val Arg Leu 
        355                 360                 365             


Ala Gly Ala Gln Ala Ile Phe Glu Ala Gln Gln Leu Ala Gly Val Arg 
    370                 375                 380                 


Arg Gly Ala Lys Pro Glu Val Pro Arg Ile Val Val Gln Pro Pro Glu 
385                 390                 395                 400 


Glu Pro Arg Pro Pro Arg Arg Lys Pro Gln Thr Arg Gly Lys Thr Phe 
                405                 410                 415     


His Gly Leu Leu Thr Arg Ala Arg Gly Pro Pro Ile Glu Gly Pro Pro 
            420                 425                 430         


Arg Pro Gln Arg Gly Ser Thr Ser Phe Leu Asp Thr Arg Phe 
        435                 440                 445     


<210>  2776
<211>  5055
<212>  DNA
<213>  Homosapiens

<400>  2776
ggtgagtctt ctgtggtccc tcccccacaa ggcccaagtc cctgggcaga gagtgggccc     60

agaggacagc aggcagcacc taggacctaa gcctgggagt tgccccctgc agacagctta    120

gacccacgac cagctccccc acccccaccc tgcggctgca tcctgggagg tgggcactct    180

tagtgccctg tgacattcat tcattccatg gcccctcagg gagctcacct tctaggagac    240

ggcacagagg ctctggccct ggcaaactgg gattcgagcc caggcatgag gcccagtcct    300

ctgccgtctg ggccacagca caccatctcc caacaaccaa gagattctct tcgtcccagc    360

ctcatcagcc cccaggggat gggagagggc aggcaccagg caacaaggtc caaagagacc    420

tcacgacttg ctcaaggtgg ccgagcctgt cccctggagg acagactcag ctgccaggcc    480

tgtccaggcc tggggactgc aaagaacaag aattccattc acacgaagcc tcccagcagc    540

cccatattgg gggggcgcca gcctcagaga ggggagggac gttaggtttc atccaaagaa    600

agcatttccg tgactcaaaa tatctgcagg ggggatactg tctagcctcc taatgtttag    660

cccagggctg ggcacacagt agggcttcaa gacctacgtg gggatgacag tggaatcaca    720

tttaggtgtc agcacactcc atgccgggtc atgagacaga aataagccac ctcagagtga    780

tggctgggtt cgttcattca tctactcttc agtcaacaaa cacttactga gaagtggctg    840

tgtgccaggc acgctttagg tgctggggtt gcctccatga acaaaacaag cagaaaactc    900

tgctgctgtg aagcaagcta aggcggagcc cagcatggca ggggcgggag gggctggctg    960

gcaagacatt gcttcctgcc ctccccccag gggcaccaca cagaacagtt tacaaagcac   1020

tcccacggtt gcgttcccat taacaagcct tcgcccccaa cacaagcctt tcctctccta   1080

gtccccggga cggtgtcagc cctgaacata gcccaggctg ggagagtggg gggcttacac   1140

ccttgggtga cttaatgtgc ccactggccc accctgccca agacctacca cttctgccct   1200

ctcagctctc cctggatcca tcgggtcccg agtgggattg cccactgggc tccaaggacc   1260

tggaggaaga gggcccctgg ggagggggct ctggcctgcc gcccacaggc tgcttccctg   1320

gctcctggcg ccaggacgtg ggcctggact gcaagggatc ccccgagggg gccgaggccc   1380

gggcttggac tgtctactac tacagcctcc tgcagagctg tctgcagcaa gctggccttc   1440

cggagactca ggaccgcggc caggtgcccc gcacaggctg tcctggggcg gaggtgacct   1500

tgtgcgttct gggctccccc agcacctttc tgcctgtgct gctggagggt ggggtccaga   1560

gcccgggaaa catgctcctt tgcctgtccc ctgcttggct gatgaaggtg ccagcacccg   1620

ggcagccggg tgaggcagcc ctgctagtct ccaaggctgt gagcttccac cctgggggcc   1680

tgacattcct ggatgacttt gtccccccgc gccgtgccac ctactttttg gcaggcctgg   1740

gcctggggcc tggccggggc cgagaggcag cagaactcgc ccgtgacctg acctgcccca   1800

caggagcttc ggctgagctg gcccggctgc tggaggaccg gctgctgaca aggcagttgc   1860

tggcccagca gggtggtgtg gctgtgccag caaccctggc tttcacctac aagccgccgg   1920

ggctgctgcg gggaggggat gccagcctag ggctacggct ggtggagctg agtggcaaag   1980

agggccagga gacgctggtg aaagaggaag tggaggcttt tctgcgctcc gaggccctgg   2040

gtgatatcct gcaggtagct gtgaagctca gtggctggcg ctggcggggg cggcaggcat   2100

ggcgtctgca cccgcgggca gagctgggtg cagtggtgga cacagtgctg gcgctgctgg   2160

agaagctgga ggaggaggag agtgtcctgg tggaggctgt gtacccacct gcccagctgc   2220

cctgctcaga tggtccttca cccggccccg gcctggccgt gcgaatctgt gctgtggtgt   2280

gtcggacaca gggtgatagg ccactgctga gcaaggtggt gtgcggcgtg ggccgcgggg   2340

accgccctct acggcaccac aactccctgc cgaggacgct ggaggtggcg ctggcccagt   2400

gcggcctggg cgaggaggcg caggtggcgg ctgtgcggca gcgcgtcaag gcggcggccg   2460

aggccgcgct ggccgccgtg ctggctctgg aggccggcct gagtgccgag cagcgcggcg   2520

ggcgccgggc gcacacggac ttcctgggcg tggatttcgc gctgacagcg gccggcggcg   2580

tgctgacccc agtggccctg gagctgaacg gcggcctgtg tctggaggcg tgcggcgcgc   2640

tggaggggct gtgggccgcg ccgcggctgg ggccggcggc cgacgaggcg gtggcggcgc   2700

cgctggtgga gaccatgctt cggcggtcgg cgcgctgcct catggaggga aaacagctgc   2760

tggtggtcgg cgctggcggc gtcagcaaga agttcgtgtg ggaggcggcg cgcgactacg   2820

ggctccagct gcacctcgtg gagtcagacc ccaaccactt tgcatcccag ttggtacaga   2880

ccttcatcca ctttgacatg acagagcacc ggagggatga ggagaacgca cggctgctgg   2940

cagagttggt gcgggctcgc ggcctcaagc tagatggctg cttctcctac tgggatgact   3000

gcctggtgct cacagccctg ctctgccagg agctaggtct gccctgcagc tccccagctg   3060

ccatgcgcct ggctaagcag aagagcctca cccagctgca cctgttgcac caccatggcc   3120

caccctggcc tgcgccctcc ctccatgctg tgccctgctg cccactggag agtgaggctg   3180

atgtggagag ggccgtgcac caggtacccc tgccaggtgt catgaagctg gagttcgggg   3240

caggtgcagt gggtgtccgg ctggtagagg atgcgccaca gtgccatgag cacttttccc   3300

ggattacccg agacttgcag ggcgaggccg accacccagg cattgggctg ggctggggca   3360

atgccatgct gctgatggag tttgtggagg gcaccgagca cgacgtggac ctggtgttgt   3420

ttggtgggcg gttgctggct gcctttgtct ccgacaatgg ccctacgagg ctgcctggct   3480

tcactgagac ggcggcctgc atgcccaccg ggctggcacc agagcaggag gcacagatgg   3540

ttcaggcagc cttccgctgt tgcctgggct gcgggttgct cgatggagtc ttcaacgtgg   3600

agctcaagct gaccggggct gggcctcggc ttatcgagat caacccccgc atgggtggct   3660

tctacctgcg tgattggatc ctggagctct atggtgttga cctgctgctg gctgctgtta   3720

tggtggcctg tggcttgcgt cctgccctgc ccacccgccc acgtgctcgt ggccatctgg   3780

tgggcgtcat gtgccttgtg tcccagcacc tgcaggccct gagttccacc gccagccgtg   3840

agaccctgca ggccctgcac gaccgtggac tgctacgcct caatctgctg gaggaggccc   3900

tggtgcctgg cgagtatgag gagccctact gcagtgtggc ctgtgccgga cccagcccca   3960

ccgaggcccg tctccgcctg ctgggcctct gccagggcct gggcatcgat gggcccagct   4020

accctgttgc ccacttcctg tctcacttca aatagcactg gggtcagggg gcagggaagc   4080

agtgctgggt ggaggcactg tggtgccctc tgctccctgg agctcttcct gcttctctcc   4140

ccatcaccat gccccagccc cagcctggcc cgctgcaatg cctaggtctg ttccagagca   4200

gcagggcaat ttagacacca aggcatcctg gactcaaggg cctcttgccc tcccgaaggc   4260

cccagtccag cctacagctt ccccagcatt ctagccttgg agaaatgaca atggccacac   4320

acacacacac acacacacac acacacctct gacgccagct ccccaggtgg gagtgggccc   4380

aaacccagcc cctcctgtcc acctctccag gtctcactct cttcctgcca tctacaagag   4440

gagaggacct ggctgggccc caagccttgg acaaatcctg ggaaaacctg agactagaac   4500

ccttgtcttc ctcttaccca aattctagga tagctctgaa gcctgctgga aacttggtgg   4560

catccaacct gcctcattcg gcctgaccgg tagaggcagg tggcctgtgg acagaagtaa   4620

tcctctttct gctcacccca ggcagacaca actgcctatg ttcccccgat gagaggaaac   4680

aggctgagag aagaaaaatg actgctccag gattatacca cagtggagag cgggtcacag   4740

gacatgatgc agggtccagg tttctgtttt gatcaagtct tacatgccca ttcagcttct   4800

aggcccccct cacctccctg ccctcattca caagtggccc tgagacacgt gaacacctcc   4860

ctcctatgca tcacaaacct tctccaccga gctttggtgc tttggcctct ggcacaccta   4920

actagcattg gcagaggaga gtctacactc tcttcctcat tcagggaaga tgctttaaga   4980

aatcctgcct ctgtgcagca gaggagctgg aggcagctcc ccaggcatcc ctccccaaat   5040

aaaggcttat gtact                                                    5055


<210>  2777
<211>  966
<212>  PRT
<213>  Homosapiens

<400>  2777

Met Cys Pro Leu Ala His Pro Ala Gln Asp Leu Pro Leu Leu Pro Ser 
1               5                   10                  15      


Gln Leu Ser Leu Asp Pro Ser Gly Pro Glu Trp Asp Cys Pro Leu Gly 
            20                  25                  30          


Ser Lys Asp Leu Glu Glu Glu Gly Pro Trp Gly Gly Gly Ser Gly Leu 
        35                  40                  45              


Pro Pro Thr Gly Cys Phe Pro Gly Ser Trp Arg Gln Asp Val Gly Leu 
    50                  55                  60                  


Asp Cys Lys Gly Ser Pro Glu Gly Ala Glu Ala Arg Ala Trp Thr Val 
65                  70                  75                  80  


Tyr Tyr Tyr Ser Leu Leu Gln Ser Cys Leu Gln Gln Ala Gly Leu Pro 
                85                  90                  95      


Glu Thr Gln Asp Arg Gly Gln Val Pro Arg Thr Gly Cys Pro Gly Ala 
            100                 105                 110         


Glu Val Thr Leu Cys Val Leu Gly Ser Pro Ser Thr Phe Leu Pro Val 
        115                 120                 125             


Leu Leu Glu Gly Gly Val Gln Ser Pro Gly Asn Met Leu Leu Cys Leu 
    130                 135                 140                 


Ser Pro Ala Trp Leu Met Lys Val Pro Ala Pro Gly Gln Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Leu Leu Val Ser Lys Ala Val Ser Phe His Pro Gly Gly Leu 
                165                 170                 175     


Thr Phe Leu Asp Asp Phe Val Pro Pro Arg Arg Ala Thr Tyr Phe Leu 
            180                 185                 190         


Ala Gly Leu Gly Leu Gly Pro Gly Arg Gly Arg Glu Ala Ala Glu Leu 
        195                 200                 205             


Ala Arg Asp Leu Thr Cys Pro Thr Gly Ala Ser Ala Glu Leu Ala Arg 
    210                 215                 220                 


Leu Leu Glu Asp Arg Leu Leu Thr Arg Gln Leu Leu Ala Gln Gln Gly 
225                 230                 235                 240 


Gly Val Ala Val Pro Ala Thr Leu Ala Phe Thr Tyr Lys Pro Pro Gly 
                245                 250                 255     


Leu Leu Arg Gly Gly Asp Ala Ser Leu Gly Leu Arg Leu Val Glu Leu 
            260                 265                 270         


Ser Gly Lys Glu Gly Gln Glu Thr Leu Val Lys Glu Glu Val Glu Ala 
        275                 280                 285             


Phe Leu Arg Ser Glu Ala Leu Gly Asp Ile Leu Gln Val Ala Val Lys 
    290                 295                 300                 


Leu Ser Gly Trp Arg Trp Arg Gly Arg Gln Ala Trp Arg Leu His Pro 
305                 310                 315                 320 


Arg Ala Glu Leu Gly Ala Val Val Asp Thr Val Leu Ala Leu Leu Glu 
                325                 330                 335     


Lys Leu Glu Glu Glu Glu Ser Val Leu Val Glu Ala Val Tyr Pro Pro 
            340                 345                 350         


Ala Gln Leu Pro Cys Ser Asp Gly Pro Ser Pro Gly Pro Gly Leu Ala 
        355                 360                 365             


Val Arg Ile Cys Ala Val Val Cys Arg Thr Gln Gly Asp Arg Pro Leu 
    370                 375                 380                 


Leu Ser Lys Val Val Cys Gly Val Gly Arg Gly Asp Arg Pro Leu Arg 
385                 390                 395                 400 


His His Asn Ser Leu Pro Arg Thr Leu Glu Val Ala Leu Ala Gln Cys 
                405                 410                 415     


Gly Leu Gly Glu Glu Ala Gln Val Ala Ala Val Arg Gln Arg Val Lys 
            420                 425                 430         


Ala Ala Ala Glu Ala Ala Leu Ala Ala Val Leu Ala Leu Glu Ala Gly 
        435                 440                 445             


Leu Ser Ala Glu Gln Arg Gly Gly Arg Arg Ala His Thr Asp Phe Leu 
    450                 455                 460                 


Gly Val Asp Phe Ala Leu Thr Ala Ala Gly Gly Val Leu Thr Pro Val 
465                 470                 475                 480 


Ala Leu Glu Leu Asn Gly Gly Leu Cys Leu Glu Ala Cys Gly Ala Leu 
                485                 490                 495     


Glu Gly Leu Trp Ala Ala Pro Arg Leu Gly Pro Ala Ala Asp Glu Ala 
            500                 505                 510         


Val Ala Ala Pro Leu Val Glu Thr Met Leu Arg Arg Ser Ala Arg Cys 
        515                 520                 525             


Leu Met Glu Gly Lys Gln Leu Leu Val Val Gly Ala Gly Gly Val Ser 
    530                 535                 540                 


Lys Lys Phe Val Trp Glu Ala Ala Arg Asp Tyr Gly Leu Gln Leu His 
545                 550                 555                 560 


Leu Val Glu Ser Asp Pro Asn His Phe Ala Ser Gln Leu Val Gln Thr 
                565                 570                 575     


Phe Ile His Phe Asp Met Thr Glu His Arg Arg Asp Glu Glu Asn Ala 
            580                 585                 590         


Arg Leu Leu Ala Glu Leu Val Arg Ala Arg Gly Leu Lys Leu Asp Gly 
        595                 600                 605             


Cys Phe Ser Tyr Trp Asp Asp Cys Leu Val Leu Thr Ala Leu Leu Cys 
    610                 615                 620                 


Gln Glu Leu Gly Leu Pro Cys Ser Ser Pro Ala Ala Met Arg Leu Ala 
625                 630                 635                 640 


Lys Gln Lys Ser Leu Thr Gln Leu His Leu Leu His His His Gly Pro 
                645                 650                 655     


Pro Trp Pro Ala Pro Ser Leu His Ala Val Pro Cys Cys Pro Leu Glu 
            660                 665                 670         


Ser Glu Ala Asp Val Glu Arg Ala Val His Gln Val Pro Leu Pro Gly 
        675                 680                 685             


Val Met Lys Leu Glu Phe Gly Ala Gly Ala Val Gly Val Arg Leu Val 
    690                 695                 700                 


Glu Asp Ala Pro Gln Cys His Glu His Phe Ser Arg Ile Thr Arg Asp 
705                 710                 715                 720 


Leu Gln Gly Glu Ala Asp His Pro Gly Ile Gly Leu Gly Trp Gly Asn 
                725                 730                 735     


Ala Met Leu Leu Met Glu Phe Val Glu Gly Thr Glu His Asp Val Asp 
            740                 745                 750         


Leu Val Leu Phe Gly Gly Arg Leu Leu Ala Ala Phe Val Ser Asp Asn 
        755                 760                 765             


Gly Pro Thr Arg Leu Pro Gly Phe Thr Glu Thr Ala Ala Cys Met Pro 
    770                 775                 780                 


Thr Gly Leu Ala Pro Glu Gln Glu Ala Gln Met Val Gln Ala Ala Phe 
785                 790                 795                 800 


Arg Cys Cys Leu Gly Cys Gly Leu Leu Asp Gly Val Phe Asn Val Glu 
                805                 810                 815     


Leu Lys Leu Thr Gly Ala Gly Pro Arg Leu Ile Glu Ile Asn Pro Arg 
            820                 825                 830         


Met Gly Gly Phe Tyr Leu Arg Asp Trp Ile Leu Glu Leu Tyr Gly Val 
        835                 840                 845             


Asp Leu Leu Leu Ala Ala Val Met Val Ala Cys Gly Leu Arg Pro Ala 
    850                 855                 860                 


Leu Pro Thr Arg Pro Arg Ala Arg Gly His Leu Val Gly Val Met Cys 
865                 870                 875                 880 


Leu Val Ser Gln His Leu Gln Ala Leu Ser Ser Thr Ala Ser Arg Glu 
                885                 890                 895     


Thr Leu Gln Ala Leu His Asp Arg Gly Leu Leu Arg Leu Asn Leu Leu 
            900                 905                 910         


Glu Glu Ala Leu Val Pro Gly Glu Tyr Glu Glu Pro Tyr Cys Ser Val 
        915                 920                 925             


Ala Cys Ala Gly Pro Ser Pro Thr Glu Ala Arg Leu Arg Leu Leu Gly 
    930                 935                 940                 


Leu Cys Gln Gly Leu Gly Ile Asp Gly Pro Ser Tyr Pro Val Ala His 
945                 950                 955                 960 


Phe Leu Ser His Phe Lys 
                965     


<210>  2778
<211>  2328
<212>  DNA
<213>  Homosapiens

<400>  2778
tgtactcgta tcccctgaag gggccatcct aggccccatc ctatccccct agcacccagt     60

actagctgac ctggatatgc cccaccctgt ggcttctgca gctgcacctc gtggagtcag    120

accccaacca ctttgcatcc cagttggtac agaccttcat ccactttgac atgacagagc    180

accggaggga tgaggagaac gcacggctgc tggcagagtt ggtgcgggct cgcggcctca    240

agctagatgg ctgcttctcc tactgggatg actgcctggt gctcacagcc ctgctctgcc    300

aggagctagg tctgccctgc agctccccag ctgccatgcg cctggctaag cagaagagcc    360

tcacccagct gcacctgttg caccaccatg gcccaccctg gcctgcgccc tccctccatg    420

ctgtgccctg ctgcccactg gagagtgagg ctgatgtgga gagggccgtg caccaggtac    480

ccctgccagg tgtcatgaag ctggagttcg gggcaggtgc agtgggtgtc cggctggtag    540

aggatgcgcc acagtgccat gagcactttt cccggattac ccgagacttg cagggcgagg    600

ccgaccaccc aggcattggg ctgggctggg gcaatgccat gctgctgatg gagtttgtgg    660

agggcaccga gcacgacgtg gacctggtgt tgtttggtgg gcggttgctg gctgcctttg    720

tctccgacaa tggccctacg aggctgcctg gcttcactga gacggcggcc tgcatgccca    780

ccgggctggc accagagcag gaggcacaga tggttcaggc agccttccgc tgttgcctgg    840

gctgcgggtt gctcgatgga gtcttcaacg tggagctcaa gctgaccggg gctgggcctc    900

ggcttatcga gatcaacccc cgcatgggtg gcttctacct gcgtgattgg atcctggagc    960

tctatggtgt tgacctgctg ctggctgctg ttatggtggc ctgtggcttg cgtcctgccc   1020

tgcccacccg cccacgtgct cgtggccatc tggtgggcgt catgtgcctt gtgtcccagc   1080

acctgcaggc cctgagttcc accgccagcc gtgagaccct gcaggccctg cacgaccgtg   1140

gactgctacg cctcaatctg ctggaggagg ccctggtgcc tggcgagtat gaggagccct   1200

actgcagtgt ggcctgtgcc ggacccagcc ccaccgaggc ccgtctccgc ctgctgggcc   1260

tctgccaggg cctgggcatc gatgggccca gctaccctgt tgcccacttc ctgtctcact   1320

tcaaatagca ctggggtcag ggggcaggga agcagtgctg ggtggaggca ctgtggtgcc   1380

ctctgctccc tggagctctt cctgcttctc tccccatcac catgccccag ccccagcctg   1440

gcccgctgca atgcctaggt ctgttccaga gcagcagggc aatttagaca ccaaggcatc   1500

ctggactcaa gggcctcttg ccctcccgaa ggccccagtc cagcctacag cttccccagc   1560

attctagcct tggagaaatg acaatggcca cacacacaca cacacacaca cacacacacc   1620

tctgacgcca gctccccagg tgggagtggg cccaaaccca gcccctcctg tccacctctc   1680

caggtctcac tctcttcctg ccatctacaa gaggagagga cctggctggg ccccaagcct   1740

tggacaaatc ctgggaaaac ctgagactag aacccttgtc ttcctcttac ccaaattcta   1800

ggatagctct gaagcctgct ggaaacttgg tggcatccaa cctgcctcat tcggcctgac   1860

cggtagaggc aggtggcctg tggacagaag taatcctctt tctgctcacc ccaggcagac   1920

acaactgcct atgttccccc gatgagagga aacaggctga gagaagaaaa atgactgctc   1980

caggattata ccacagtgga gagcgggtca caggacatga tgcagggtcc aggtttctgt   2040

tttgatcaag tcttacatgc ccattcagct tctaggcccc cctcacctcc ctgccctcat   2100

tcacaagtgg ccctgagaca cgtgaacacc tccctcctat gcatcacaaa ccttctccac   2160

cgagctttgg tgctttggcc tctggcacac ctaactagca ttggcagagg agagtctaca   2220

ctctcttcct cattcaggga agatgcttta agaaatcctg cctctgtgca gcagaggagc   2280

tggaggcagc tccccaggca tccctcccca aataaaggct tatgtact                2328


<210>  2779
<211>  385
<212>  PRT
<213>  Homosapiens

<400>  2779

Met Thr Glu His Arg Arg Asp Glu Glu Asn Ala Arg Leu Leu Ala Glu 
1               5                   10                  15      


Leu Val Arg Ala Arg Gly Leu Lys Leu Asp Gly Cys Phe Ser Tyr Trp 
            20                  25                  30          


Asp Asp Cys Leu Val Leu Thr Ala Leu Leu Cys Gln Glu Leu Gly Leu 
        35                  40                  45              


Pro Cys Ser Ser Pro Ala Ala Met Arg Leu Ala Lys Gln Lys Ser Leu 
    50                  55                  60                  


Thr Gln Leu His Leu Leu His His His Gly Pro Pro Trp Pro Ala Pro 
65                  70                  75                  80  


Ser Leu His Ala Val Pro Cys Cys Pro Leu Glu Ser Glu Ala Asp Val 
                85                  90                  95      


Glu Arg Ala Val His Gln Val Pro Leu Pro Gly Val Met Lys Leu Glu 
            100                 105                 110         


Phe Gly Ala Gly Ala Val Gly Val Arg Leu Val Glu Asp Ala Pro Gln 
        115                 120                 125             


Cys His Glu His Phe Ser Arg Ile Thr Arg Asp Leu Gln Gly Glu Ala 
    130                 135                 140                 


Asp His Pro Gly Ile Gly Leu Gly Trp Gly Asn Ala Met Leu Leu Met 
145                 150                 155                 160 


Glu Phe Val Glu Gly Thr Glu His Asp Val Asp Leu Val Leu Phe Gly 
                165                 170                 175     


Gly Arg Leu Leu Ala Ala Phe Val Ser Asp Asn Gly Pro Thr Arg Leu 
            180                 185                 190         


Pro Gly Phe Thr Glu Thr Ala Ala Cys Met Pro Thr Gly Leu Ala Pro 
        195                 200                 205             


Glu Gln Glu Ala Gln Met Val Gln Ala Ala Phe Arg Cys Cys Leu Gly 
    210                 215                 220                 


Cys Gly Leu Leu Asp Gly Val Phe Asn Val Glu Leu Lys Leu Thr Gly 
225                 230                 235                 240 


Ala Gly Pro Arg Leu Ile Glu Ile Asn Pro Arg Met Gly Gly Phe Tyr 
                245                 250                 255     


Leu Arg Asp Trp Ile Leu Glu Leu Tyr Gly Val Asp Leu Leu Leu Ala 
            260                 265                 270         


Ala Val Met Val Ala Cys Gly Leu Arg Pro Ala Leu Pro Thr Arg Pro 
        275                 280                 285             


Arg Ala Arg Gly His Leu Val Gly Val Met Cys Leu Val Ser Gln His 
    290                 295                 300                 


Leu Gln Ala Leu Ser Ser Thr Ala Ser Arg Glu Thr Leu Gln Ala Leu 
305                 310                 315                 320 


His Asp Arg Gly Leu Leu Arg Leu Asn Leu Leu Glu Glu Ala Leu Val 
                325                 330                 335     


Pro Gly Glu Tyr Glu Glu Pro Tyr Cys Ser Val Ala Cys Ala Gly Pro 
            340                 345                 350         


Ser Pro Thr Glu Ala Arg Leu Arg Leu Leu Gly Leu Cys Gln Gly Leu 
        355                 360                 365             


Gly Ile Asp Gly Pro Ser Tyr Pro Val Ala His Phe Leu Ser His Phe 
    370                 375                 380                 


Lys 
385 


<210>  2780
<211>  1760
<212>  DNA
<213>  Homosapiens

<400>  2780
ggagagatga tgtttaggtc cgggactgtc agtcagtgcg cggccaggta cgggccgacg     60

ggcccgcggg gccggcgccg ccatggcggc cgtgtttgat ttggatttgg agacggagga    120

aggcagcgag ggcgagggcg agccagagct cagccccgcg gacgcatgtc cccttgccga    180

gttgagggca gctggcctag agcctgtggg acactatgaa gaggtggagc tgactgagac    240

cagcgtgaac gttggcccag agcgcatcgg gccccactgc tttgagctgc tgcgtgtgct    300

gggcaagggg ggctatggca aggtgttcca ggtgcgaaag gtgcaaggca ccaacttggg    360

caaaatatat gccatgaaag tcctaaggaa ggccaaaatt gtgcgcaatg ccaaggacac    420

agcacacaca cgggctgagc ggaacattct agagtcagtg aagcacccct ttattgtgga    480

actggcctat gccttccaga ctggtggcaa actctacctc atccttgagt gcctcagtgg    540

tggcgagctc ttcacgcatc tggagcgaga gggcatcttc ctggaagata cggcctgctt    600

ctacctggct gagatcacgc tggccctggg ccatctccac tcccagggca tcatctaccg    660

ggacctcaag cccgagaaca tcatgctcag cagccagggc cacatcaaac tgaccgactt    720

tggactctgc aaggagtcta tccatgaggg cgccgtcact cacaccttct gcggcaccat    780

tgagtacatg gcccctgaga ttctggtgcg cagtggccac aaccgggctg tggactggtg    840

gagcctgggg gccctgatcc gcccttcacc gcagagaacc ggaagaaaac catggataag    900

atcatcaggg gcaagctggc actgcccccc tacctcaccc cagatgcccg ggaccttgtc    960

aaaaagtttc tgaaacggaa tcccagccag cggattgggg gtggcccagg ggatgctgct   1020

gatgtgcaga gacatccctt tttccggcac atgaattggg acgaccttct ggcctggcgt   1080

gtggaccccc ctttcaggcc ctgtctgcag tcagaggagg acgtgagcca gtttgatacc   1140

cgcttcacac ggcagacgcc ggtggacagt cctgatgaca cagccctcag cgagagtgcc   1200

aaccaggcct tcctgggctt cacatacgtg gcgccgtctg tcctggacag catcaaggag   1260

ggcttctcct tccagcccaa gctgcgctca cccaggcgcc tcaacagtag cccccgggcc   1320

cccgtcagcc ccctcaagtt ctcccctttt gaggggtttc ggcccagccc cagcctgccg   1380

gagcccacgg agctacctct acctccactc ctgccaccgc cgccgccctc gaccaccgcc   1440

cctctcccca tccgtccccc ctcagggacc aagaagtcca agaggggccg tgggcgtcca   1500

gggcgctagg aagccgggtg ggggtgaggg tagcccttga gccctgtccc tgcggctgtg   1560

agagcagcag gaccctgggc cagttccaga gacctggggg tgtgtctggg ggtggggtgt   1620

gagtgcgtat gaaagtgtgt gtctgctggg gcagctgtgc ccctgaatca tgggcacgga   1680

gggccgcccg ccacgccccg cgctcaactg ctcccgtgga agattaaagg gctgaatcat   1740

ggtgctgaaa aaaaaaaaaa                                               1760


<210>  2781
<211>  296
<212>  PRT
<213>  Homosapiens

<400>  2781

Met Ala Ala Val Phe Asp Leu Asp Leu Glu Thr Glu Glu Gly Ser Glu 
1               5                   10                  15      


Gly Glu Gly Glu Pro Glu Leu Ser Pro Ala Asp Ala Cys Pro Leu Ala 
            20                  25                  30          


Glu Leu Arg Ala Ala Gly Leu Glu Pro Val Gly His Tyr Glu Glu Val 
        35                  40                  45              


Glu Leu Thr Glu Thr Ser Val Asn Val Gly Pro Glu Arg Ile Gly Pro 
    50                  55                  60                  


His Cys Phe Glu Leu Leu Arg Val Leu Gly Lys Gly Gly Tyr Gly Lys 
65                  70                  75                  80  


Val Phe Gln Val Arg Lys Val Gln Gly Thr Asn Leu Gly Lys Ile Tyr 
                85                  90                  95      


Ala Met Lys Val Leu Arg Lys Ala Lys Ile Val Arg Asn Ala Lys Asp 
            100                 105                 110         


Thr Ala His Thr Arg Ala Glu Arg Asn Ile Leu Glu Ser Val Lys His 
        115                 120                 125             


Pro Phe Ile Val Glu Leu Ala Tyr Ala Phe Gln Thr Gly Gly Lys Leu 
    130                 135                 140                 


Tyr Leu Ile Leu Glu Cys Leu Ser Gly Gly Glu Leu Phe Thr His Leu 
145                 150                 155                 160 


Glu Arg Glu Gly Ile Phe Leu Glu Asp Thr Ala Cys Phe Tyr Leu Ala 
                165                 170                 175     


Glu Ile Thr Leu Ala Leu Gly His Leu His Ser Gln Gly Ile Ile Tyr 
            180                 185                 190         


Arg Asp Leu Lys Pro Glu Asn Ile Met Leu Ser Ser Gln Gly His Ile 
        195                 200                 205             


Lys Leu Thr Asp Phe Gly Leu Cys Lys Glu Ser Ile His Glu Gly Ala 
    210                 215                 220                 


Val Thr His Thr Phe Cys Gly Thr Ile Glu Tyr Met Ala Pro Glu Ile 
225                 230                 235                 240 


Leu Val Arg Ser Gly His Asn Arg Ala Val Asp Trp Trp Ser Leu Gly 
                245                 250                 255     


Ala Leu Ile Arg Pro Ser Pro Gln Arg Thr Gly Arg Lys Pro Trp Ile 
            260                 265                 270         


Arg Ser Ser Gly Ala Ser Trp His Cys Pro Pro Thr Ser Pro Gln Met 
        275                 280                 285             


Pro Gly Thr Leu Ser Lys Ser Phe 
    290                 295     


<210>  2782
<211>  1782
<212>  DNA
<213>  Homosapiens

<400>  2782
ggagagatga tgtttaggtc cgggactgtc agtcagtgcg cggccaggta cgggccgacg     60

ggcccgcggg gccggcgccg ccatggcggc cgtgtttgat ttggatttgg agacggagga    120

aggcagcgag ggcgagggcg agccagagct cagccccgcg gacgcatgtc cccttgccga    180

gttgagggca gctggcctag agcctgtggg acactatgaa gaggtggagc tgactgagac    240

cagcgtgaac gttggcccag agcgcatcgg gccccactgc tttgagctgc tgcgtgtgct    300

gggcaagggg ggctatggca aggtgttcca ggtgcgaaag gtgcaaggca ccaacttggg    360

caaaatatat gccatgaaag tcctaaggaa ggccaaaatt gtgcgcaatg ccaaggacac    420

agcacacaca cgggctgagc ggaacattct agagtcagtg aagcacccct ttattgtgga    480

actggcctat gccttccaga ctggtggcaa actctacctc atccttgagt gcctcagtgg    540

tggcgagctc ttcacgcatc tggagcgaga gggcatcttc ctggaagata cggcctgctt    600

ctacctggct gagatcacgc tggccctggg ccatctccac tcccagggca tcatctaccg    660

ggacctcaag cccgagaaca tcatgctcag cagccagggc cacatcaaac tgaccgactt    720

tggactctgc aaggagtcta tccatgaggg cgccgtcact cacaccttct gcggcaccat    780

tgagtacatg gcccctgaga ttctggtgcg cagtggccac aaccgggctg tggactggtg    840

gagcctgggg gccctgatgt acgacatgct cactggatcg ccgcccttca ccgcagagaa    900

ccggaagaaa accatggata agatcatcag gggcaagctg gcactgcccc cctacctcac    960

cccagatgcc cgggaccttg tcaaaaagtt tctgaaacgg aatcccagcc agcggattgg   1020

gggtggccca ggggatgctg ctgatgtgca gagacatccc tttttccggc acatgaattg   1080

ggacgacctt ctggcctggc gtgtggaccc ccctttcagg ccctgtctgc agtcagagga   1140

ggacgtgagc cagtttgata cccgcttcac acggcagacg ccggtggaca gtcctgatga   1200

cacagccctc agcgagagtg ccaaccaggc cttcctgggc ttcacatacg tggcgccgtc   1260

tgtcctggac agcatcaagg agggcttctc cttccagccc aagctgcgct cacccaggcg   1320

cctcaacagt agcccccggg cccccgtcag ccccctcaag ttctcccctt ttgaggggtt   1380

tcggcccagc cccagcctgc cggagcccac ggagctacct ctacctccac tcctgccacc   1440

gccgccgccc tcgaccaccg cccctctccc catccgtccc ccctcaggga ccaagaagtc   1500

caagaggggc cgtgggcgtc cagggcgcta ggaagccggg tgggggtgag ggtagccctt   1560

gagccctgtc cctgcggctg tgagagcagc aggaccctgg gccagttcca gagacctggg   1620

ggtgtgtctg ggggtggggt gtgagtgcgt atgaaagtgt gtgtctgctg gggcagctgt   1680

gcccctgaat catgggcacg gagggccgcc cgccacgccc cgcgctcaac tgctcccgtg   1740

gaagattaaa gggctgaatc atggtgctga aaaaaaaaaa aa                      1782


<210>  2783
<211>  482
<212>  PRT
<213>  Homosapiens

<400>  2783

Met Ala Ala Val Phe Asp Leu Asp Leu Glu Thr Glu Glu Gly Ser Glu 
1               5                   10                  15      


Gly Glu Gly Glu Pro Glu Leu Ser Pro Ala Asp Ala Cys Pro Leu Ala 
            20                  25                  30          


Glu Leu Arg Ala Ala Gly Leu Glu Pro Val Gly His Tyr Glu Glu Val 
        35                  40                  45              


Glu Leu Thr Glu Thr Ser Val Asn Val Gly Pro Glu Arg Ile Gly Pro 
    50                  55                  60                  


His Cys Phe Glu Leu Leu Arg Val Leu Gly Lys Gly Gly Tyr Gly Lys 
65                  70                  75                  80  


Val Phe Gln Val Arg Lys Val Gln Gly Thr Asn Leu Gly Lys Ile Tyr 
                85                  90                  95      


Ala Met Lys Val Leu Arg Lys Ala Lys Ile Val Arg Asn Ala Lys Asp 
            100                 105                 110         


Thr Ala His Thr Arg Ala Glu Arg Asn Ile Leu Glu Ser Val Lys His 
        115                 120                 125             


Pro Phe Ile Val Glu Leu Ala Tyr Ala Phe Gln Thr Gly Gly Lys Leu 
    130                 135                 140                 


Tyr Leu Ile Leu Glu Cys Leu Ser Gly Gly Glu Leu Phe Thr His Leu 
145                 150                 155                 160 


Glu Arg Glu Gly Ile Phe Leu Glu Asp Thr Ala Cys Phe Tyr Leu Ala 
                165                 170                 175     


Glu Ile Thr Leu Ala Leu Gly His Leu His Ser Gln Gly Ile Ile Tyr 
            180                 185                 190         


Arg Asp Leu Lys Pro Glu Asn Ile Met Leu Ser Ser Gln Gly His Ile 
        195                 200                 205             


Lys Leu Thr Asp Phe Gly Leu Cys Lys Glu Ser Ile His Glu Gly Ala 
    210                 215                 220                 


Val Thr His Thr Phe Cys Gly Thr Ile Glu Tyr Met Ala Pro Glu Ile 
225                 230                 235                 240 


Leu Val Arg Ser Gly His Asn Arg Ala Val Asp Trp Trp Ser Leu Gly 
                245                 250                 255     


Ala Leu Met Tyr Asp Met Leu Thr Gly Ser Pro Pro Phe Thr Ala Glu 
            260                 265                 270         


Asn Arg Lys Lys Thr Met Asp Lys Ile Ile Arg Gly Lys Leu Ala Leu 
        275                 280                 285             


Pro Pro Tyr Leu Thr Pro Asp Ala Arg Asp Leu Val Lys Lys Phe Leu 
    290                 295                 300                 


Lys Arg Asn Pro Ser Gln Arg Ile Gly Gly Gly Pro Gly Asp Ala Ala 
305                 310                 315                 320 


Asp Val Gln Arg His Pro Phe Phe Arg His Met Asn Trp Asp Asp Leu 
                325                 330                 335     


Leu Ala Trp Arg Val Asp Pro Pro Phe Arg Pro Cys Leu Gln Ser Glu 
            340                 345                 350         


Glu Asp Val Ser Gln Phe Asp Thr Arg Phe Thr Arg Gln Thr Pro Val 
        355                 360                 365             


Asp Ser Pro Asp Asp Thr Ala Leu Ser Glu Ser Ala Asn Gln Ala Phe 
    370                 375                 380                 


Leu Gly Phe Thr Tyr Val Ala Pro Ser Val Leu Asp Ser Ile Lys Glu 
385                 390                 395                 400 


Gly Phe Ser Phe Gln Pro Lys Leu Arg Ser Pro Arg Arg Leu Asn Ser 
                405                 410                 415     


Ser Pro Arg Ala Pro Val Ser Pro Leu Lys Phe Ser Pro Phe Glu Gly 
            420                 425                 430         


Phe Arg Pro Ser Pro Ser Leu Pro Glu Pro Thr Glu Leu Pro Leu Pro 
        435                 440                 445             


Pro Leu Leu Pro Pro Pro Pro Pro Ser Thr Thr Ala Pro Leu Pro Ile 
    450                 455                 460                 


Arg Pro Pro Ser Gly Thr Lys Lys Ser Lys Arg Gly Arg Gly Arg Pro 
465                 470                 475                 480 


Gly Arg 
        


<210>  2784
<211>  917
<212>  DNA
<213>  Homosapiens

<400>  2784
acttctcgct cgacacagcc agagctggag gtgggtgccc ggcacggagg ggcctgcgga     60

ccaatggctc tgccctgcac cttagggctc gggatgctgc tggccctgcc aggggccttg    120

ggctcgggtg gcagcgcgga ggacagcgtg ggctccagct ctgtcaccgt tgtcctgctg    180

ctgctgctgc tcctactgct ggccactggc ctagcactgg cctggcgccg cctcagccgt    240

gactcagggg gctactacca cccggcccgc ctaggtgccg cgctgtgggg ccgcacgcgg    300

cgcctgctct gggccagccc cccaggtcgc tggctgcagg cccgagctga gctggggtcc    360

acagacaatg accttgagcg acaggaggat gagcaggaca cagactatga ccacgtcgcg    420

gatggtggcc tgcaggctga ccctggggaa ggcgagcagc aatgtggaga ggcgtccagc    480

ccagagcagg tccccgtgcg ggctgaggaa gccagagaca gtgacacgga gggcgacctg    540

gtcctcggct ccccaggacc agcgagcgca gggggcagtg ctgaggccct gctgagtgac    600

ctgcacgcct ttgctggcag cgcagcctgg gatgacagcg ccagggcagc tgggggccag    660

ggcctccatg tcaccgcact gtagaggccg gtcttggtgt cccatccctg tcacagccgc    720

tcactccccg tgcctctgct tcccaagatg ccatggctgg actggacccc cagcccacat    780

gaccatgcct cagactgtca ccccctacca gttcccaagt ccatgtgtac cccgctcacc    840

acgggaacgg ccccccccaa ccacaggcat caggcaacca tttgaaataa aactccttca    900

gcctgtgaaa aaaaaaa                                                   917


<210>  2785
<211>  206
<212>  PRT
<213>  Homosapiens

<400>  2785

Met Ala Leu Pro Cys Thr Leu Gly Leu Gly Met Leu Leu Ala Leu Pro 
1               5                   10                  15      


Gly Ala Leu Gly Ser Gly Gly Ser Ala Glu Asp Ser Val Gly Ser Ser 
            20                  25                  30          


Ser Val Thr Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Ala Thr 
        35                  40                  45              


Gly Leu Ala Leu Ala Trp Arg Arg Leu Ser Arg Asp Ser Gly Gly Tyr 
    50                  55                  60                  


Tyr His Pro Ala Arg Leu Gly Ala Ala Leu Trp Gly Arg Thr Arg Arg 
65                  70                  75                  80  


Leu Leu Trp Ala Ser Pro Pro Gly Arg Trp Leu Gln Ala Arg Ala Glu 
                85                  90                  95      


Leu Gly Ser Thr Asp Asn Asp Leu Glu Arg Gln Glu Asp Glu Gln Asp 
            100                 105                 110         


Thr Asp Tyr Asp His Val Ala Asp Gly Gly Leu Gln Ala Asp Pro Gly 
        115                 120                 125             


Glu Gly Glu Gln Gln Cys Gly Glu Ala Ser Ser Pro Glu Gln Val Pro 
    130                 135                 140                 


Val Arg Ala Glu Glu Ala Arg Asp Ser Asp Thr Glu Gly Asp Leu Val 
145                 150                 155                 160 


Leu Gly Ser Pro Gly Pro Ala Ser Ala Gly Gly Ser Ala Glu Ala Leu 
                165                 170                 175     


Leu Ser Asp Leu His Ala Phe Ala Gly Ser Ala Ala Trp Asp Asp Ser 
            180                 185                 190         


Ala Arg Ala Ala Gly Gly Gln Gly Leu His Val Thr Ala Leu 
        195                 200                 205     


<210>  2786
<211>  1920
<212>  DNA
<213>  Homosapiens

<400>  2786
attatgagga gcaagaacgc gaaggggcct cgggtccgct aggccgggat ccggagccgc     60

ccgaagccgg tgccgcagcc ccctgcgccc ccggtgcccc cgacatgtcc ttccgcaaag    120

tggtccggca gagcaaattc cggcatgtgt tcgggcagcc ggtcaagaac gaccagtgct    180

atgaggacat tcgcgtgtcc cgtgttacct gggacagcac cttctgcgcc gtcaacccca    240

agttcctggc ggtgattgtg gaggccagtg gagggggtgc ctttctggtg ctccccctaa    300

gcaagacggg ccgcattgac aaggcctacc cgacggtgtg tgggcacacg ggacctgtcc    360

tggacatcga ctggtgtcct cacaacgacg aagtcatagc cagcggctcg gaggactgca    420

cggtcatggt gtggcagatc ccagagaacg ggctgacctc cccgctgaca gagccggtgg    480

tggtactgga ggggcacacc aagcgagtgg gcatcatcgc ctggcacccc acggcccgaa    540

acgtgctgct cagtgcaggc tgcgacaacg tggtactcat ctggaatgtg ggcacagcgg    600

aggagctgta ccgcctggac agcctgcacc ctgacctcat ctacaatgtc agctggaacc    660

acaatggcag cctgttttgc tcagcatgca aggacaagag cgtgcgcatc atcgaccccc    720

gtcggggcac cctggtggca gagcgggaga aggctcatga gggggcccgg cccatgcggg    780

ccatcttcct ggcagatggc aaggtgttca ccacaggctt cagccgaatg agcgagcggc    840

agctggcgct ctgggaccca gaaaacctcg aggaacccat ggccctgcag gaactggact    900

cgagcaacgg ggccctgctg cccttctacg accccgacac cagtgtggtc tacgtctgcg    960

gcaagggtga ctccagcatc cggtactttg agatcacaga ggagcctccc tacatccact   1020

tcctgaacac gttcaccagc aaggagccgc agcggggtat gggcagcatg cccaagcggg   1080

gcctggaggt cagcaagtgc gagatcgccc ggttctacaa actgcatgag cgcaagtgtg   1140

agcccatcgt catgactgtg ccaagaaagt cggacctctt ccaggatgat ctgtaccccg   1200

acacagccgg gcccgaggca gccctggagg ctgaggagtg ggtgagcggg cgggatgccg   1260

acccgatcct catctcactg cgggaggcct acgtgcccag caagcagcgg gacctgaaga   1320

tcagccggcg caacgtgttg tctgacagcc ggcccgccat ggccccgggc tcctcccacc   1380

taggggcccc cgcctccacc accactgctg ctgatgccac ccccagcggc agcctggcca   1440

gagccgggga ggctgggaag ctggaggagg tgatgcagga gctgcgggcc ctgagggcgc   1500

tggtcaagga gcagggcgac cgcatctgcc gcctggagga gcagctgggc cgcatggaga   1560

acggggatgc gtagggccac agccacacgc caccttcatc tcctccgccg cccccttccc   1620

actcagcttc tgccagcggg tcgcaccggg ctagctggct gcccagagcc tctgaggcag   1680

cgcaggggtc agttcccacc cccacccgtc ccaggcccag gccgaagcca gcgcccagct   1740

ttcctcactg ttcctgtgga ggatgtctac gcccaggcga gctcctcgac ctctgaggga   1800

ccatctcccc gaccactgcc cagccctctg ctccctcccc agaggaggcg ggagggtggg   1860

ctctatattt tcattccaaa taaaattctc tttctaaaag ccaaaaaaaa aaaaaaaaaa   1920


<210>  2787
<211>  489
<212>  PRT
<213>  Homosapiens

<400>  2787

Met Ser Phe Arg Lys Val Val Arg Gln Ser Lys Phe Arg His Val Phe 
1               5                   10                  15      


Gly Gln Pro Val Lys Asn Asp Gln Cys Tyr Glu Asp Ile Arg Val Ser 
            20                  25                  30          


Arg Val Thr Trp Asp Ser Thr Phe Cys Ala Val Asn Pro Lys Phe Leu 
        35                  40                  45              


Ala Val Ile Val Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro 
    50                  55                  60                  


Leu Ser Lys Thr Gly Arg Ile Asp Lys Ala Tyr Pro Thr Val Cys Gly 
65                  70                  75                  80  


His Thr Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Glu 
                85                  90                  95      


Val Ile Ala Ser Gly Ser Glu Asp Cys Thr Val Met Val Trp Gln Ile 
            100                 105                 110         


Pro Glu Asn Gly Leu Thr Ser Pro Leu Thr Glu Pro Val Val Val Leu 
        115                 120                 125             


Glu Gly His Thr Lys Arg Val Gly Ile Ile Ala Trp His Pro Thr Ala 
    130                 135                 140                 


Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Val Leu Ile Trp 
145                 150                 155                 160 


Asn Val Gly Thr Ala Glu Glu Leu Tyr Arg Leu Asp Ser Leu His Pro 
                165                 170                 175     


Asp Leu Ile Tyr Asn Val Ser Trp Asn His Asn Gly Ser Leu Phe Cys 
            180                 185                 190         


Ser Ala Cys Lys Asp Lys Ser Val Arg Ile Ile Asp Pro Arg Arg Gly 
        195                 200                 205             


Thr Leu Val Ala Glu Arg Glu Lys Ala His Glu Gly Ala Arg Pro Met 
    210                 215                 220                 


Arg Ala Ile Phe Leu Ala Asp Gly Lys Val Phe Thr Thr Gly Phe Ser 
225                 230                 235                 240 


Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asp Pro Glu Asn Leu Glu 
                245                 250                 255     


Glu Pro Met Ala Leu Gln Glu Leu Asp Ser Ser Asn Gly Ala Leu Leu 
            260                 265                 270         


Pro Phe Tyr Asp Pro Asp Thr Ser Val Val Tyr Val Cys Gly Lys Gly 
        275                 280                 285             


Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Glu Glu Pro Pro Tyr Ile 
    290                 295                 300                 


His Phe Leu Asn Thr Phe Thr Ser Lys Glu Pro Gln Arg Gly Met Gly 
305                 310                 315                 320 


Ser Met Pro Lys Arg Gly Leu Glu Val Ser Lys Cys Glu Ile Ala Arg 
                325                 330                 335     


Phe Tyr Lys Leu His Glu Arg Lys Cys Glu Pro Ile Val Met Thr Val 
            340                 345                 350         


Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro Asp Thr Ala 
        355                 360                 365             


Gly Pro Glu Ala Ala Leu Glu Ala Glu Glu Trp Val Ser Gly Arg Asp 
    370                 375                 380                 


Ala Asp Pro Ile Leu Ile Ser Leu Arg Glu Ala Tyr Val Pro Ser Lys 
385                 390                 395                 400 


Gln Arg Asp Leu Lys Ile Ser Arg Arg Asn Val Leu Ser Asp Ser Arg 
                405                 410                 415     


Pro Ala Met Ala Pro Gly Ser Ser His Leu Gly Ala Pro Ala Ser Thr 
            420                 425                 430         


Thr Thr Ala Ala Asp Ala Thr Pro Ser Gly Ser Leu Ala Arg Ala Gly 
        435                 440                 445             


Glu Ala Gly Lys Leu Glu Glu Val Met Gln Glu Leu Arg Ala Leu Arg 
    450                 455                 460                 


Ala Leu Val Lys Glu Gln Gly Asp Arg Ile Cys Arg Leu Glu Glu Gln 
465                 470                 475                 480 


Leu Gly Arg Met Glu Asn Gly Asp Ala 
                485                 


<210>  2788
<211>  1927
<212>  DNA
<213>  Homosapiens

<400>  2788
ctccgggtcc ctctgtcact tcctgaatcc tgcttcctgc ttcccagagg ccgggatccg     60

gagccgcccg aagccggtgc cgcagccccc tgcgcccccg gtgcccccga catgtccttc    120

cgcaaagtgg tccggcagag caaattccgg catgtgttcg ggcagccggt caagaacgac    180

cagtgctatg aggacattcg cgtgtcccgt gttacctggg acagcacctt ctgcgccgtc    240

aaccccaagt tcctggcggt gattgtggag gccagtggag ggggtgcctt tctggtgctc    300

cccctaagca agacgggccg cattgacaag gcctacccga cggtgtgtgg gcacacggga    360

cctgtcctgg acatcgactg gtgtcctcac aacgacgaag tcatagccag cggctcggag    420

gactgcacgg tcatggtgtg gcagatccca gagaacgggc tgacctcccc gctgacagag    480

ccggtggtgg tactggaggg gcacaccaag cgagtgggca tcatcgcctg gcaccccacg    540

gcccgaaacg tgctgctcag tgcaggctgc gacaacgtgg tactcatctg gaatgtgggc    600

acagcggagg agctgtaccg cctggacagc ctgcaccctg acctcatcta caatgtcagc    660

tggaaccaca atggcagcct gttttgctca gcatgcaagg acaagagcgt gcgcatcatc    720

gacccccgtc ggggcaccct ggtggcagag cgggagaagg ctcatgaggg ggcccggccc    780

atgcgggcca tcttcctggc agatggcaag gtgttcacca caggcttcag ccgaatgagc    840

gagcggcagc tggcgctctg ggacccagaa aacctcgagg aacccatggc cctgcaggaa    900

ctggactcga gcaacggggc cctgctgccc ttctacgacc ccgacaccag tgtggtctac    960

gtctgcggca agggtgactc cagcatccgg tactttgaga tcacagagga gcctccctac   1020

atccacttcc tgaacacgtt caccagcaag gagccgcagc ggggtatggg cagcatgccc   1080

aagcggggcc tggaggtcag caagtgcgag atcgcccggt tctacaaact gcatgagcgc   1140

aagtgtgagc ccatcgtcat gactgtgcca agaaagtcgg acctcttcca ggatgatctg   1200

taccccgaca cagccgggcc cgaggcagcc ctggaggctg aggagtgggt gagcgggcgg   1260

gatgccgacc cgatcctcat ctcactgcgg gaggcctacg tgcccagcaa gcagcgggac   1320

ctgaagatca gccggcgcaa cgtgttgtct gacagccggc ccgccatggc cccgggctcc   1380

tcccacctag gggcccccgc ctccaccacc actgctgctg atgccacccc cagcggcagc   1440

ctggccagag ccggggaggc tgggaagctg gaggaggtga tgcaggagct gcgggccctg   1500

agggcgctgg tcaaggagca gggcgaccgc atctgccgcc tggaggagca gctgggccgc   1560

atggagaacg gggatgcgta gggccacagc cacacgccac cttcatctcc tccgccgccc   1620

ccttcccact cagcttctgc cagcgggtcg caccgggcta gctggctgcc cagagcctct   1680

gaggcagcgc aggggtcagt tcccaccccc acccgtccca ggcccaggcc gaagccagcg   1740

cccagctttc ctcactgttc ctgtggagga tgtctacgcc caggcgagct cctcgacctc   1800

tgagggacca tctccccgac cactgcccag ccctctgctc cctccccaga ggaggcggga   1860

gggtgggctc tatattttca ttccaaataa aattctcttt ctaaaagcca aaaaaaaaaa   1920

aaaaaaa                                                             1927


<210>  2789
<211>  489
<212>  PRT
<213>  Homosapiens

<400>  2789

Met Ser Phe Arg Lys Val Val Arg Gln Ser Lys Phe Arg His Val Phe 
1               5                   10                  15      


Gly Gln Pro Val Lys Asn Asp Gln Cys Tyr Glu Asp Ile Arg Val Ser 
            20                  25                  30          


Arg Val Thr Trp Asp Ser Thr Phe Cys Ala Val Asn Pro Lys Phe Leu 
        35                  40                  45              


Ala Val Ile Val Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro 
    50                  55                  60                  


Leu Ser Lys Thr Gly Arg Ile Asp Lys Ala Tyr Pro Thr Val Cys Gly 
65                  70                  75                  80  


His Thr Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Glu 
                85                  90                  95      


Val Ile Ala Ser Gly Ser Glu Asp Cys Thr Val Met Val Trp Gln Ile 
            100                 105                 110         


Pro Glu Asn Gly Leu Thr Ser Pro Leu Thr Glu Pro Val Val Val Leu 
        115                 120                 125             


Glu Gly His Thr Lys Arg Val Gly Ile Ile Ala Trp His Pro Thr Ala 
    130                 135                 140                 


Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Val Leu Ile Trp 
145                 150                 155                 160 


Asn Val Gly Thr Ala Glu Glu Leu Tyr Arg Leu Asp Ser Leu His Pro 
                165                 170                 175     


Asp Leu Ile Tyr Asn Val Ser Trp Asn His Asn Gly Ser Leu Phe Cys 
            180                 185                 190         


Ser Ala Cys Lys Asp Lys Ser Val Arg Ile Ile Asp Pro Arg Arg Gly 
        195                 200                 205             


Thr Leu Val Ala Glu Arg Glu Lys Ala His Glu Gly Ala Arg Pro Met 
    210                 215                 220                 


Arg Ala Ile Phe Leu Ala Asp Gly Lys Val Phe Thr Thr Gly Phe Ser 
225                 230                 235                 240 


Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asp Pro Glu Asn Leu Glu 
                245                 250                 255     


Glu Pro Met Ala Leu Gln Glu Leu Asp Ser Ser Asn Gly Ala Leu Leu 
            260                 265                 270         


Pro Phe Tyr Asp Pro Asp Thr Ser Val Val Tyr Val Cys Gly Lys Gly 
        275                 280                 285             


Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Glu Glu Pro Pro Tyr Ile 
    290                 295                 300                 


His Phe Leu Asn Thr Phe Thr Ser Lys Glu Pro Gln Arg Gly Met Gly 
305                 310                 315                 320 


Ser Met Pro Lys Arg Gly Leu Glu Val Ser Lys Cys Glu Ile Ala Arg 
                325                 330                 335     


Phe Tyr Lys Leu His Glu Arg Lys Cys Glu Pro Ile Val Met Thr Val 
            340                 345                 350         


Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro Asp Thr Ala 
        355                 360                 365             


Gly Pro Glu Ala Ala Leu Glu Ala Glu Glu Trp Val Ser Gly Arg Asp 
    370                 375                 380                 


Ala Asp Pro Ile Leu Ile Ser Leu Arg Glu Ala Tyr Val Pro Ser Lys 
385                 390                 395                 400 


Gln Arg Asp Leu Lys Ile Ser Arg Arg Asn Val Leu Ser Asp Ser Arg 
                405                 410                 415     


Pro Ala Met Ala Pro Gly Ser Ser His Leu Gly Ala Pro Ala Ser Thr 
            420                 425                 430         


Thr Thr Ala Ala Asp Ala Thr Pro Ser Gly Ser Leu Ala Arg Ala Gly 
        435                 440                 445             


Glu Ala Gly Lys Leu Glu Glu Val Met Gln Glu Leu Arg Ala Leu Arg 
    450                 455                 460                 


Ala Leu Val Lys Glu Gln Gly Asp Arg Ile Cys Arg Leu Glu Glu Gln 
465                 470                 475                 480 


Leu Gly Arg Met Glu Asn Gly Asp Ala 
                485                 


<210>  2790
<211>  1429
<212>  DNA
<213>  Homosapiens

<400>  2790
cccaaatgga cactaccatg gaagctgacc tgggtgccac tggccacagg ccccgcacag     60

agcttgatga tgaggactcc tacccccaag gtggctggga cacggtcttc ctggtggccc    120

tgctgctcct tgggctgcca gccaatgggt tgatggcgtg gctggccggc tcccaggccc    180

ggcatggagc tggcacgcgt ctggcgctgc tcctgctcag cctggccctc tctgacttct    240

tgttcctggc agcagcggcc ttccagatcc tagagatccg gcatggggga cactggccgc    300

tggggacagc tgcctgccgc ttctactact tcctatgggg cgtgtcctac tcctccggcc    360

tcttcctgct ggccgccctc agcctcgacc gctgcctgct ggcgctgtgc ccacactggt    420

accctgggca ccgcccagtc cgcctgcccc tctgggtctg cgccggtgtc tgggtgctgg    480

ccacactctt cagcgtgccc tggctggtct tccccgaggc tgccgtctgg tggtacgacc    540

tggtcatctg cctggacttc tgggacagcg aggagctgtc gctgaggatg ctggaggtcc    600

tggggggctt cctgcctttc ctcctgctgc tcgtctgcca cgtgctcacc caggccacag    660

cctgtcgcac ctgccaccgc caacagcagc ccgcagcctg ccggggcttc gcccgtgtgg    720

ccaggaccat tctgtcagcc tatgtggtcc tgaggctgcc ctaccagctg gcccagctgc    780

tctacctggc cttcctgtgg gacgtctact ctggctacct gctctgggag gccctggtct    840

actccgacta cctgatccta ctcaacagct gcctcagccc cttcctctgc ctcatggcca    900

gtgccgacct ccggaccctg ctgcgctccg tgctctcgtc cttcgcggca gctctctgcg    960

aggagcggcc gggcagcttc acgcccactg agccacagac ccagctagat tctgagggtc   1020

caactctgcc agagccgatg gcagaggccc agtcacagat ggatcctgtg gcccagcctc   1080

aggtgaaccc cacactccag ccacgatcgg atcccacagc tcagccacag ctgaacccta   1140

cggcccagcc acagtcggat cccacagccc agccacagct gaacctcatg gcccagccac   1200

agtcagattc tgtggcccag ccacaggcag acactaacgt ccagacccct gcacctgctg   1260

ccagttctgt gcccagtccc tgtgatgaag cttccccaac cccatcctcg catcctaccc   1320

caggggccct tgaggaccca gccacacctc ctgcctctga aggagaaagc cccagcagca   1380

ccccgccaga ggcggccccg ggcgcaggcc ccacgtgagg gtccaggaa               1429


<210>  2791
<211>  470
<212>  PRT
<213>  Homosapiens

<400>  2791

Met Asp Thr Thr Met Glu Ala Asp Leu Gly Ala Thr Gly His Arg Pro 
1               5                   10                  15      


Arg Thr Glu Leu Asp Asp Glu Asp Ser Tyr Pro Gln Gly Gly Trp Asp 
            20                  25                  30          


Thr Val Phe Leu Val Ala Leu Leu Leu Leu Gly Leu Pro Ala Asn Gly 
        35                  40                  45              


Leu Met Ala Trp Leu Ala Gly Ser Gln Ala Arg His Gly Ala Gly Thr 
    50                  55                  60                  


Arg Leu Ala Leu Leu Leu Leu Ser Leu Ala Leu Ser Asp Phe Leu Phe 
65                  70                  75                  80  


Leu Ala Ala Ala Ala Phe Gln Ile Leu Glu Ile Arg His Gly Gly His 
                85                  90                  95      


Trp Pro Leu Gly Thr Ala Ala Cys Arg Phe Tyr Tyr Phe Leu Trp Gly 
            100                 105                 110         


Val Ser Tyr Ser Ser Gly Leu Phe Leu Leu Ala Ala Leu Ser Leu Asp 
        115                 120                 125             


Arg Cys Leu Leu Ala Leu Cys Pro His Trp Tyr Pro Gly His Arg Pro 
    130                 135                 140                 


Val Arg Leu Pro Leu Trp Val Cys Ala Gly Val Trp Val Leu Ala Thr 
145                 150                 155                 160 


Leu Phe Ser Val Pro Trp Leu Val Phe Pro Glu Ala Ala Val Trp Trp 
                165                 170                 175     


Tyr Asp Leu Val Ile Cys Leu Asp Phe Trp Asp Ser Glu Glu Leu Ser 
            180                 185                 190         


Leu Arg Met Leu Glu Val Leu Gly Gly Phe Leu Pro Phe Leu Leu Leu 
        195                 200                 205             


Leu Val Cys His Val Leu Thr Gln Ala Thr Ala Cys Arg Thr Cys His 
    210                 215                 220                 


Arg Gln Gln Gln Pro Ala Ala Cys Arg Gly Phe Ala Arg Val Ala Arg 
225                 230                 235                 240 


Thr Ile Leu Ser Ala Tyr Val Val Leu Arg Leu Pro Tyr Gln Leu Ala 
                245                 250                 255     


Gln Leu Leu Tyr Leu Ala Phe Leu Trp Asp Val Tyr Ser Gly Tyr Leu 
            260                 265                 270         


Leu Trp Glu Ala Leu Val Tyr Ser Asp Tyr Leu Ile Leu Leu Asn Ser 
        275                 280                 285             


Cys Leu Ser Pro Phe Leu Cys Leu Met Ala Ser Ala Asp Leu Arg Thr 
    290                 295                 300                 


Leu Leu Arg Ser Val Leu Ser Ser Phe Ala Ala Ala Leu Cys Glu Glu 
305                 310                 315                 320 


Arg Pro Gly Ser Phe Thr Pro Thr Glu Pro Gln Thr Gln Leu Asp Ser 
                325                 330                 335     


Glu Gly Pro Thr Leu Pro Glu Pro Met Ala Glu Ala Gln Ser Gln Met 
            340                 345                 350         


Asp Pro Val Ala Gln Pro Gln Val Asn Pro Thr Leu Gln Pro Arg Ser 
        355                 360                 365             


Asp Pro Thr Ala Gln Pro Gln Leu Asn Pro Thr Ala Gln Pro Gln Ser 
    370                 375                 380                 


Asp Pro Thr Ala Gln Pro Gln Leu Asn Leu Met Ala Gln Pro Gln Ser 
385                 390                 395                 400 


Asp Ser Val Ala Gln Pro Gln Ala Asp Thr Asn Val Gln Thr Pro Ala 
                405                 410                 415     


Pro Ala Ala Ser Ser Val Pro Ser Pro Cys Asp Glu Ala Ser Pro Thr 
            420                 425                 430         


Pro Ser Ser His Pro Thr Pro Gly Ala Leu Glu Asp Pro Ala Thr Pro 
        435                 440                 445             


Pro Ala Ser Glu Gly Glu Ser Pro Ser Ser Thr Pro Pro Glu Ala Ala 
    450                 455                 460                 


Pro Gly Ala Gly Pro Thr 
465                 470 


<210>  2792
<211>  1466
<212>  DNA
<213>  Homosapiens

<400>  2792
cataagcagc tttatgggtc ctgaaagcca agggtgccca ggggtgtggt gtctctgagc     60

cctgttatcc ctcccccatg accacagagc aggcaagggg gcagcagggc ccaaatctgg    120

ccattggccg tcagaagccc cctgcggggg ttgtgactcc caagagtgat gcagaggagc    180

ccccgttgac caggaagagg agcaagaagg agagggggct ccgagggtct cgaaagcgca    240

ctggcagctc tggggagcag acaggccccg aggccccggg gagcagcaat aaccctccca    300

gcactggaga ggggccggcg ggcgcacccc ctgcatcccc tgggccggcc tcttctcgcc    360

agtcccaccg acatcgtcct gactccctgc acgacgctgc tcagaggaca tacgggcccc    420

tgctcaatcg agtcttcggg aaggaccgcg aactgggccc cgaggagcta gacgagcttc    480

aggccgcctt cgaggagttt gacactgacc gtgacggcta catcagccac cgggagctgg    540

gtgactgcat gcggaccctg ggctacatgc ccaccgagat ggagctcctg gaggtctcgc    600

agcacatcaa gatgcgcatg ggcggccgtg tggactttga ggagtttgta gaactgatag    660

gcccaaagct gagggaggag acggcgcaca tgctgggggt gcgagagctg cgcatcgcct    720

tccgagagtt tgacagggac agggatggac gaattacggt ggcggagctg cgggaggcgg    780

taccggctct gctcggggag ccgctggcgg gtcctgagct ggacgagatg ctccgagaag    840

tggacctcaa tggggatggc accgtagact ttgacgagtt tgtgatgatg ctctcccgcc    900

actgaggctc caggagggaa tatctgttgc ccctgcggcc ccagacacca gccagaccca    960

ggctgcaggc ctcccccagg agcctccagg atggagatgg agacccagca gcccccagac   1020

tacttctatc cctgaaaaca cctggcctca atgttggctt gttatgttac ctgcccaccc   1080

tcatccttac ctcctcctac tcaagctgcc tggagaagac ctgctctcag ctgcccaccg   1140

ttcctcagtg tgagcaagat ttgggtctct ccagacctct gggaggtagg gagttccctg   1200

gcactggcag cattcagtgg ggacccccca gtggcatgat gaatggagag gatggctgga   1260

ccccttccac tacttatgtt tataattttt ttttttttta atgaacttga gccgggtgca   1320

gtggctcaca cctgtaagcc cagctgtcag ggggcagaag cgggaggata gcttgagccc   1380

aggagtgcaa gacctgcctg ggcaatatac tgagacccca ttctccacaa aaaggaaaaa   1440

taaaagacaa aaaaacaaac aaaaaa                                        1466


<210>  2793
<211>  275
<212>  PRT
<213>  Homosapiens

<400>  2793

Met Thr Thr Glu Gln Ala Arg Gly Gln Gln Gly Pro Asn Leu Ala Ile 
1               5                   10                  15      


Gly Arg Gln Lys Pro Pro Ala Gly Val Val Thr Pro Lys Ser Asp Ala 
            20                  25                  30          


Glu Glu Pro Pro Leu Thr Arg Lys Arg Ser Lys Lys Glu Arg Gly Leu 
        35                  40                  45              


Arg Gly Ser Arg Lys Arg Thr Gly Ser Ser Gly Glu Gln Thr Gly Pro 
    50                  55                  60                  


Glu Ala Pro Gly Ser Ser Asn Asn Pro Pro Ser Thr Gly Glu Gly Pro 
65                  70                  75                  80  


Ala Gly Ala Pro Pro Ala Ser Pro Gly Pro Ala Ser Ser Arg Gln Ser 
                85                  90                  95      


His Arg His Arg Pro Asp Ser Leu His Asp Ala Ala Gln Arg Thr Tyr 
            100                 105                 110         


Gly Pro Leu Leu Asn Arg Val Phe Gly Lys Asp Arg Glu Leu Gly Pro 
        115                 120                 125             


Glu Glu Leu Asp Glu Leu Gln Ala Ala Phe Glu Glu Phe Asp Thr Asp 
    130                 135                 140                 


Arg Asp Gly Tyr Ile Ser His Arg Glu Leu Gly Asp Cys Met Arg Thr 
145                 150                 155                 160 


Leu Gly Tyr Met Pro Thr Glu Met Glu Leu Leu Glu Val Ser Gln His 
                165                 170                 175     


Ile Lys Met Arg Met Gly Gly Arg Val Asp Phe Glu Glu Phe Val Glu 
            180                 185                 190         


Leu Ile Gly Pro Lys Leu Arg Glu Glu Thr Ala His Met Leu Gly Val 
        195                 200                 205             


Arg Glu Leu Arg Ile Ala Phe Arg Glu Phe Asp Arg Asp Arg Asp Gly 
    210                 215                 220                 


Arg Ile Thr Val Ala Glu Leu Arg Glu Ala Val Pro Ala Leu Leu Gly 
225                 230                 235                 240 


Glu Pro Leu Ala Gly Pro Glu Leu Asp Glu Met Leu Arg Glu Val Asp 
                245                 250                 255     


Leu Asn Gly Asp Gly Thr Val Asp Phe Asp Glu Phe Val Met Met Leu 
            260                 265                 270         


Ser Arg His 
        275 


<210>  2794
<211>  961
<212>  DNA
<213>  Homosapiens

<400>  2794
aaaaaaaaaa aaaaaaaaac aatgcggggg cggggcagcg gcgacgctgg gtgtgtgggc     60

gcaaatggcg gcggcgcacg gcgcctgagc gggccggggc catgagcgcc gcccggcccc    120

agttcagcat tgatgatgcc ttcgagctgt ccctggagga cgggggccct gggcccgagt    180

ccagcggggt cgcgcgcttt gggccgctgc acttcgagcg tcgggcccgg ttcgaggtgg    240

ctgacgagga caagcagtcc cggctgcgct accagaacct ggagaacgat gaggatggag    300

cccaggcctc tccggagccg gatgggggag tcggcaccag ggattccagc cgaacttcca    360

tccgcagctc ccagtggtcc ttcagcacca tcagcagcag cacccagcgc tcctacaaca    420

cctgctgcag ctggacccaa caccctttga tccagaagaa ccgccgagtg gtgctggcct    480

ccttcctgct cctgctgctg gggctggtgc tgatcctggt cggcgtggga ctggaggcga    540

ccccctctcc aggtgtctcc agcgccatct tcttcgtgcc gggcttcctg ttgttggtgc    600

ctggagtcta tcacgtgatc ttcatctact gcgcggtcaa gggccaccgg ggcttccagt    660

tcttctacct gccctacttc gagaagtgat cgcggcgcag cgtggacccc ttgcgcccat    720

gggggcgccc ctcttgccct gttccgttcc cctcatctca agggaagagg ccctccagga    780

ccctcgaaac cccagcccct agggagtttg ctcaggaagt tcggggcatg caggcctggc    840

cctgggaaag ccgcccgtcg cctgctctgt gccttaactt attctcgggc cgtgcggctg    900

ctaggttgct gttattttgt gctaataaaa gagtaattaa ttccaaaaaa aaaaaaaaaa    960

a                                                                    961


<210>  2795
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  2795

Met Ser Ala Ala Arg Pro Gln Phe Ser Ile Asp Asp Ala Phe Glu Leu 
1               5                   10                  15      


Ser Leu Glu Asp Gly Gly Pro Gly Pro Glu Ser Ser Gly Val Ala Arg 
            20                  25                  30          


Phe Gly Pro Leu His Phe Glu Arg Arg Ala Arg Phe Glu Val Ala Asp 
        35                  40                  45              


Glu Asp Lys Gln Ser Arg Leu Arg Tyr Gln Asn Leu Glu Asn Asp Glu 
    50                  55                  60                  


Asp Gly Ala Gln Ala Ser Pro Glu Pro Asp Gly Gly Val Gly Thr Arg 
65                  70                  75                  80  


Asp Ser Ser Arg Thr Ser Ile Arg Ser Ser Gln Trp Ser Phe Ser Thr 
                85                  90                  95      


Ile Ser Ser Ser Thr Gln Arg Ser Tyr Asn Thr Cys Cys Ser Trp Thr 
            100                 105                 110         


Gln His Pro Leu Ile Gln Lys Asn Arg Arg Val Val Leu Ala Ser Phe 
        115                 120                 125             


Leu Leu Leu Leu Leu Gly Leu Val Leu Ile Leu Val Gly Val Gly Leu 
    130                 135                 140                 


Glu Ala Thr Pro Ser Pro Gly Val Ser Ser Ala Ile Phe Phe Val Pro 
145                 150                 155                 160 


Gly Phe Leu Leu Leu Val Pro Gly Val Tyr His Val Ile Phe Ile Tyr 
                165                 170                 175     


Cys Ala Val Lys Gly His Arg Gly Phe Gln Phe Phe Tyr Leu Pro Tyr 
            180                 185                 190         


Phe Glu Lys 
        195 


<210>  2796
<211>  1244
<212>  DNA
<213>  Homosapiens

<400>  2796
gcacgaggaa aatggcgcta gctcggaagc taccgaggtg ctaggagttg ccgaagcaag     60

tccggaagct accgagcgag tccggaagtt gccgaaaggg agcagcgggg aaggaggatg    120

gcggatatca tcgcaagact ccgggaggac gggatccaaa aacgtgtgat acaggaaggc    180

cgaggagagc tcccggactt tcaagatggg accaaggcca cgttccacta ccggacgctg    240

cacagtgacg acgagggcac cgtgctggac gacagccggg ctcgtggcaa gcccatggag    300

ctcatcattg gcaagaagtt caagctgcct gtgtgggaga ccatcgtgtg caccatgcga    360

gaaggggaga ttgcccagtt cctctgtgac atcaagcatg tggtcctgta cccgctggtg    420

gccaagagtc tccgcaacat cgcggtgggc aaggaccccc tggagggcca gcggcactgc    480

tgcggtgttg cacagatgcg tgaacacagc tccctgggcc atgctgacct ggacgccctg    540

cagcagaacc cccagcccct catcttccac atggagatgc tgaaggtgga gagccctggc    600

acgtaccagc aggacccatg ggccatgaca gacgaagaga aggcaaaggc agtgccactt    660

atccaccagg agggcaaccg gttgtaccgc gaggggcatg tgaaggaggc tgctgccaag    720

tactacgatg ccattgcctg cctcaagaac ctgcagatga aggaacagcc tgggtcccct    780

gaatggatcc agctggacaa gcagatcacg ccgctgctgc tcaactactg ccagtgcaag    840

ctggtggtcg aggagtacta cgaggtgctg gaccactgct cttccatcct caacaagtac    900

gacgacaacg tcaaggccta cttcaagcgg ggcaaggccc acgcggccgt gtggaatgcc    960

caggaggccc aggctgactt tgccaaagtg ctggagctgg acccagccct ggcgcctgtg   1020

gtgagccgag agctgcgggc cctggaggca cggatccggc agaaggacga agaggacaaa   1080

gcccggttcc gggggatctt ctcccattga caggagcact tggccctgcc ttacctgcca   1140

agcccactgc tgcagctgcc agcccccctg cccgtgctgc gtcatgcttc tgtgtatata   1200

aaggccttta tttatctctc aaaaaaaaaa aaaaaaaaaa aaaa                    1244


<210>  2797
<211>  330
<212>  PRT
<213>  Homosapiens

<400>  2797

Met Ala Asp Ile Ile Ala Arg Leu Arg Glu Asp Gly Ile Gln Lys Arg 
1               5                   10                  15      


Val Ile Gln Glu Gly Arg Gly Glu Leu Pro Asp Phe Gln Asp Gly Thr 
            20                  25                  30          


Lys Ala Thr Phe His Tyr Arg Thr Leu His Ser Asp Asp Glu Gly Thr 
        35                  40                  45              


Val Leu Asp Asp Ser Arg Ala Arg Gly Lys Pro Met Glu Leu Ile Ile 
    50                  55                  60                  


Gly Lys Lys Phe Lys Leu Pro Val Trp Glu Thr Ile Val Cys Thr Met 
65                  70                  75                  80  


Arg Glu Gly Glu Ile Ala Gln Phe Leu Cys Asp Ile Lys His Val Val 
                85                  90                  95      


Leu Tyr Pro Leu Val Ala Lys Ser Leu Arg Asn Ile Ala Val Gly Lys 
            100                 105                 110         


Asp Pro Leu Glu Gly Gln Arg His Cys Cys Gly Val Ala Gln Met Arg 
        115                 120                 125             


Glu His Ser Ser Leu Gly His Ala Asp Leu Asp Ala Leu Gln Gln Asn 
    130                 135                 140                 


Pro Gln Pro Leu Ile Phe His Met Glu Met Leu Lys Val Glu Ser Pro 
145                 150                 155                 160 


Gly Thr Tyr Gln Gln Asp Pro Trp Ala Met Thr Asp Glu Glu Lys Ala 
                165                 170                 175     


Lys Ala Val Pro Leu Ile His Gln Glu Gly Asn Arg Leu Tyr Arg Glu 
            180                 185                 190         


Gly His Val Lys Glu Ala Ala Ala Lys Tyr Tyr Asp Ala Ile Ala Cys 
        195                 200                 205             


Leu Lys Asn Leu Gln Met Lys Glu Gln Pro Gly Ser Pro Glu Trp Ile 
    210                 215                 220                 


Gln Leu Asp Lys Gln Ile Thr Pro Leu Leu Leu Asn Tyr Cys Gln Cys 
225                 230                 235                 240 


Lys Leu Val Val Glu Glu Tyr Tyr Glu Val Leu Asp His Cys Ser Ser 
                245                 250                 255     


Ile Leu Asn Lys Tyr Asp Asp Asn Val Lys Ala Tyr Phe Lys Arg Gly 
            260                 265                 270         


Lys Ala His Ala Ala Val Trp Asn Ala Gln Glu Ala Gln Ala Asp Phe 
        275                 280                 285             


Ala Lys Val Leu Glu Leu Asp Pro Ala Leu Ala Pro Val Val Ser Arg 
    290                 295                 300                 


Glu Leu Arg Ala Leu Glu Ala Arg Ile Arg Gln Lys Asp Glu Glu Asp 
305                 310                 315                 320 


Lys Ala Arg Phe Arg Gly Ile Phe Ser His 
                325                 330 


<210>  2798
<211>  4211
<212>  DNA
<213>  Homosapiens

<400>  2798
cgcgggcggc ggtgctaggc tcgcctctgc ctccctcgtg gcgggcccgg acatggggtc     60

ccgtggcctg agtccctcgg ccggcgcgca gggctcgggg ccgcgcgcac cttccccgca    120

ctgactgtcg cgccgtgccc tgcgccagga ggagcggagg ccgcgcgcgg cccgccgagc    180

gccttcagga tgctcatcaa ggaataccac attctgctgc ccatgagcct ggacgagtac    240

caggtggccc agctctacat gatccagaaa aagagccggg aggagtctag tggtgagggc    300

agcggcgtgg agatcctggc caaccggccc tacacggatg ggcccggggg cagcgggcaa    360

tacacacaca aggtgtacca cgtgggctcc cacatcccag gctggttccg ggcactgctg    420

cccaaggctg ccctgcaggt agaagaggaa tcctggaatg cctaccccta cacccgaacc    480

cggtacacct gccctttcgt ggagaaattc tccattgaaa ttgagaccta ttacctgcct    540

gatggggggc agcagccaaa cgtcttcaac ctgagcgggg ccgagaggag acagcgcatc    600

ctggacacca tcgacatcgt gcgggatgca gtggccccag gcgagtacaa agcagaagag    660

gacccccggc tttatcactc ggtcaagacg ggccgagggc cactgtctga tgactgggca    720

cggacggcgg cacagacggg gccccttatg tgtgcctata agctgtgcaa ggttgagttc    780

cgctactggg gcatgcaagc caagatcgag cagttcatcc atgatgtagg tctgcgtcgg    840

gtgatgctgc gggcccaccg ccaggcctgg tgctggcagg atgagtggac agagctgagc    900

atggctgaca tccgggcact ggaagaggag actgctcgca tgctggccca gcgcatggcc    960

aagtgcaaca caggcagtga ggggtccgag gcccagcccc ccgggaaacc gagcaccgag   1020

gcccggtctg cggccagcaa cactggcacc cccgatgggc ctgaggcccc cccaggccca   1080

gatgcctccc ccgatgccag ctttgggaag cagtggtcct catcctcccg ttcctcctac   1140

tcatcccaac atggaggggc tgtgtctccc cagagcttgt ctgagtggcg catgcagaac   1200

attgcccgag actctgagaa cagctccgag gaagagttct ttgatgccca cgaaggcttc   1260

tcggacagtg aggaggtctt ccccaaggag atgaccaagt ggaactccaa tgacttcatt   1320

gatgcctttg cctccccagt ggaggcagag ggaacgccag agcctggagc cgaggcagct   1380

aaaggcattg aggatggggc ccaagcaccc agggactcag agggcctgga tggagccggg   1440

gagctggggg ctgaggcatg cgcagtccac gccctcttcc ttatcctgca cagcggcaac   1500

atcctggact caggccctgg agacgccaac tccaagcagg cggatgtgca gacgctgagc   1560

tccgccttcg aggccgtcac ccgcatccac ttccctgagg ccttgggcca cgtggcgctg   1620

cgactggtgc cctgtccacc catctgcgcc gccgcctatg cccttgtctc caacctgagc   1680

ccttacagcc acgatgggga cagcctgtct cgctcccaag accacattcc actggctgcc   1740

ctgccactgc tggccacctc atcctcccgc taccagggcg ccgtggccac cgtcattgcc   1800

cgcaccaacc aggcctactc agccttcctg cgctcacctg agggtgccgg cttctgtggg   1860

caggtcgcac tgattggaga tggtgttggt ggcatcctgg gctttgatgc actctgccac   1920

agtgctaacg cgggcaccgg gagtcggggc agcagccgcc gtgggagcat gaacaatgag   1980

ctgctctctc cggagtttgg cccagtgcgg gaccccctgg cagatggtgt ggaaggcctg   2040

ggtcggggca gcccagaacc ctcggccttg cctccccagc gcatccccag cgacatggcc   2100

agtcctgagc ccgagggctc tcagaacagc cttcaggcag cccccgcaac cacctcctcc   2160

tgggagcccc ggcgggcaag cacggccttc tgcccacccg ctgccagttc cgaggcacct   2220

gacggcccca gcagcactgc ccgccttgac ttcaaggtct ctggcttctt cctcttcggc   2280

tccccactgg gcctggtgct ggctctgcgc aaaactgtga tgcccgccct ggaggcagcc   2340

cagatgcgcc cagcctgtga acagatctac aacctcttcc acgcggccga cccctgcgcc   2400

tcacgcctcg agcccctgct ggccccgaag ttccaggcca tcgccccact gaccgtgccc   2460

cgctaccaga agttccccct gggagatggc tcatccctgc tgctggccga cactctgcag   2520

acgcactcca gcctctttct ggaggagctg gagatgctgg tgccctcaac acccacctct   2580

actagcggtg ccttctggaa gggcagtgag ttggccactg accccccggc ccagccagcc   2640

gcccccagca ccaccagtga ggtggttaag atcctggagc gctggtgggg gaccaagcgg   2700

atcgactact cgctgtactg ccccgaggcg ctcaccgcct ttcccaccgt cacgctgccc   2760

cacctcttcc acgccagcta ctgggagtcc gccgacgtgg tggcgttcat cctgcgccag   2820

gtgatcgaga aggagcggcc acagctggcg gaatgcgagg agccgtccat ctacagcccg   2880

gccttcccca gggagaagtg gcagcgaaaa cgcacgcagg tcaagatccg gaacgtcact   2940

tccaaccacc gggcgagcga cacggtggtg tgcgagggcc gcccccaggt gctaagcggg   3000

cgcttcatgt acgggcccct ggacgtcgtc acgctcactg gagagaaggt ggatgtctac   3060

atcatgacgc agccgctgtc gggcaagtgg atccactttg gcaccgaagt caccaatagc   3120

tcgggccgcc tcaccttccc agttccccca gaacgcgcgc tgggcattgg tgtctacccc   3180

gtgcgcatgg tggtcagggg cgaccacacc tatgccgaat gctgcctgac tgtggtggcc   3240

cgcggcacgg aggctgtggt cttcagcatc gacggctcct tcaccgccag cgtctccatc   3300

atgggcagcg accccaaggt gcgagctggc gccgtggacg tggtcaggca ctggcaggac   3360

tccggctacc tgatcgtgta tgtcacaggc cggccggata tgcagaagca ccgcgtggtg   3420

gcatggctgt cgcagcacaa cttcccccac ggcgtcgtct ccttctgcga cggcctcacc   3480

cacgacccac tacgccagaa ggcaatgttt ctccagagcc tggttcagga ggtaggactg   3540

aacatcgtgg ccggttatgg gtctcccaaa gatgtggctg tatacacggc gctggggctg   3600

tccccgagcc agacctacat cgtgggccgt gccgtgcgga agctacaggc gcagtgccag   3660

ttcctgtcag acggctatgt ggcccacctg ggccagctgg aagcgggctc gcactcgcat   3720

gcctcctcgg gacccccgag agctgccttg ggcaagagca gctatggtgt ggctgccccc   3780

gtggacttcc tgcgcaaaca gagccagctg cttcgctcga ggggccccag ccaggcggag   3840

cgtgagggcc cgggaacacc acccaccacc ctggcacggg gcaaagcacg gagcatcagc   3900

ctgaagctgg acagcgagga gtgaggccca caccagcctg gacctgggtt atttattgac   3960

acacccaagg ggcccgaggg gctgcgtgtg ggaggctggg gacccagact tttggcccca   4020

gcgctggccc ccccagcccc acaccctata tctccgtgtg ctcctcggtg ttacttccct   4080

ttcatatgag gggacccagc gccgggggga gggaggaggg cgtgggcatg ggcgcagagg   4140

cttttccagt gtgtataaat ccatgaaaat aaacgccacc tgcaccccaa aaaaaaaaaa   4200

aaaaaaaaaa a                                                        4211


<210>  2799
<211>  1244
<212>  PRT
<213>  Homosapiens

<400>  2799

Met Leu Ile Lys Glu Tyr His Ile Leu Leu Pro Met Ser Leu Asp Glu 
1               5                   10                  15      


Tyr Gln Val Ala Gln Leu Tyr Met Ile Gln Lys Lys Ser Arg Glu Glu 
            20                  25                  30          


Ser Ser Gly Glu Gly Ser Gly Val Glu Ile Leu Ala Asn Arg Pro Tyr 
        35                  40                  45              


Thr Asp Gly Pro Gly Gly Ser Gly Gln Tyr Thr His Lys Val Tyr His 
    50                  55                  60                  


Val Gly Ser His Ile Pro Gly Trp Phe Arg Ala Leu Leu Pro Lys Ala 
65                  70                  75                  80  


Ala Leu Gln Val Glu Glu Glu Ser Trp Asn Ala Tyr Pro Tyr Thr Arg 
                85                  90                  95      


Thr Arg Tyr Thr Cys Pro Phe Val Glu Lys Phe Ser Ile Glu Ile Glu 
            100                 105                 110         


Thr Tyr Tyr Leu Pro Asp Gly Gly Gln Gln Pro Asn Val Phe Asn Leu 
        115                 120                 125             


Ser Gly Ala Glu Arg Arg Gln Arg Ile Leu Asp Thr Ile Asp Ile Val 
    130                 135                 140                 


Arg Asp Ala Val Ala Pro Gly Glu Tyr Lys Ala Glu Glu Asp Pro Arg 
145                 150                 155                 160 


Leu Tyr His Ser Val Lys Thr Gly Arg Gly Pro Leu Ser Asp Asp Trp 
                165                 170                 175     


Ala Arg Thr Ala Ala Gln Thr Gly Pro Leu Met Cys Ala Tyr Lys Leu 
            180                 185                 190         


Cys Lys Val Glu Phe Arg Tyr Trp Gly Met Gln Ala Lys Ile Glu Gln 
        195                 200                 205             


Phe Ile His Asp Val Gly Leu Arg Arg Val Met Leu Arg Ala His Arg 
    210                 215                 220                 


Gln Ala Trp Cys Trp Gln Asp Glu Trp Thr Glu Leu Ser Met Ala Asp 
225                 230                 235                 240 


Ile Arg Ala Leu Glu Glu Glu Thr Ala Arg Met Leu Ala Gln Arg Met 
                245                 250                 255     


Ala Lys Cys Asn Thr Gly Ser Glu Gly Ser Glu Ala Gln Pro Pro Gly 
            260                 265                 270         


Lys Pro Ser Thr Glu Ala Arg Ser Ala Ala Ser Asn Thr Gly Thr Pro 
        275                 280                 285             


Asp Gly Pro Glu Ala Pro Pro Gly Pro Asp Ala Ser Pro Asp Ala Ser 
    290                 295                 300                 


Phe Gly Lys Gln Trp Ser Ser Ser Ser Arg Ser Ser Tyr Ser Ser Gln 
305                 310                 315                 320 


His Gly Gly Ala Val Ser Pro Gln Ser Leu Ser Glu Trp Arg Met Gln 
                325                 330                 335     


Asn Ile Ala Arg Asp Ser Glu Asn Ser Ser Glu Glu Glu Phe Phe Asp 
            340                 345                 350         


Ala His Glu Gly Phe Ser Asp Ser Glu Glu Val Phe Pro Lys Glu Met 
        355                 360                 365             


Thr Lys Trp Asn Ser Asn Asp Phe Ile Asp Ala Phe Ala Ser Pro Val 
    370                 375                 380                 


Glu Ala Glu Gly Thr Pro Glu Pro Gly Ala Glu Ala Ala Lys Gly Ile 
385                 390                 395                 400 


Glu Asp Gly Ala Gln Ala Pro Arg Asp Ser Glu Gly Leu Asp Gly Ala 
                405                 410                 415     


Gly Glu Leu Gly Ala Glu Ala Cys Ala Val His Ala Leu Phe Leu Ile 
            420                 425                 430         


Leu His Ser Gly Asn Ile Leu Asp Ser Gly Pro Gly Asp Ala Asn Ser 
        435                 440                 445             


Lys Gln Ala Asp Val Gln Thr Leu Ser Ser Ala Phe Glu Ala Val Thr 
    450                 455                 460                 


Arg Ile His Phe Pro Glu Ala Leu Gly His Val Ala Leu Arg Leu Val 
465                 470                 475                 480 


Pro Cys Pro Pro Ile Cys Ala Ala Ala Tyr Ala Leu Val Ser Asn Leu 
                485                 490                 495     


Ser Pro Tyr Ser His Asp Gly Asp Ser Leu Ser Arg Ser Gln Asp His 
            500                 505                 510         


Ile Pro Leu Ala Ala Leu Pro Leu Leu Ala Thr Ser Ser Ser Arg Tyr 
        515                 520                 525             


Gln Gly Ala Val Ala Thr Val Ile Ala Arg Thr Asn Gln Ala Tyr Ser 
    530                 535                 540                 


Ala Phe Leu Arg Ser Pro Glu Gly Ala Gly Phe Cys Gly Gln Val Ala 
545                 550                 555                 560 


Leu Ile Gly Asp Gly Val Gly Gly Ile Leu Gly Phe Asp Ala Leu Cys 
                565                 570                 575     


His Ser Ala Asn Ala Gly Thr Gly Ser Arg Gly Ser Ser Arg Arg Gly 
            580                 585                 590         


Ser Met Asn Asn Glu Leu Leu Ser Pro Glu Phe Gly Pro Val Arg Asp 
        595                 600                 605             


Pro Leu Ala Asp Gly Val Glu Gly Leu Gly Arg Gly Ser Pro Glu Pro 
    610                 615                 620                 


Ser Ala Leu Pro Pro Gln Arg Ile Pro Ser Asp Met Ala Ser Pro Glu 
625                 630                 635                 640 


Pro Glu Gly Ser Gln Asn Ser Leu Gln Ala Ala Pro Ala Thr Thr Ser 
                645                 650                 655     


Ser Trp Glu Pro Arg Arg Ala Ser Thr Ala Phe Cys Pro Pro Ala Ala 
            660                 665                 670         


Ser Ser Glu Ala Pro Asp Gly Pro Ser Ser Thr Ala Arg Leu Asp Phe 
        675                 680                 685             


Lys Val Ser Gly Phe Phe Leu Phe Gly Ser Pro Leu Gly Leu Val Leu 
    690                 695                 700                 


Ala Leu Arg Lys Thr Val Met Pro Ala Leu Glu Ala Ala Gln Met Arg 
705                 710                 715                 720 


Pro Ala Cys Glu Gln Ile Tyr Asn Leu Phe His Ala Ala Asp Pro Cys 
                725                 730                 735     


Ala Ser Arg Leu Glu Pro Leu Leu Ala Pro Lys Phe Gln Ala Ile Ala 
            740                 745                 750         


Pro Leu Thr Val Pro Arg Tyr Gln Lys Phe Pro Leu Gly Asp Gly Ser 
        755                 760                 765             


Ser Leu Leu Leu Ala Asp Thr Leu Gln Thr His Ser Ser Leu Phe Leu 
    770                 775                 780                 


Glu Glu Leu Glu Met Leu Val Pro Ser Thr Pro Thr Ser Thr Ser Gly 
785                 790                 795                 800 


Ala Phe Trp Lys Gly Ser Glu Leu Ala Thr Asp Pro Pro Ala Gln Pro 
                805                 810                 815     


Ala Ala Pro Ser Thr Thr Ser Glu Val Val Lys Ile Leu Glu Arg Trp 
            820                 825                 830         


Trp Gly Thr Lys Arg Ile Asp Tyr Ser Leu Tyr Cys Pro Glu Ala Leu 
        835                 840                 845             


Thr Ala Phe Pro Thr Val Thr Leu Pro His Leu Phe His Ala Ser Tyr 
    850                 855                 860                 


Trp Glu Ser Ala Asp Val Val Ala Phe Ile Leu Arg Gln Val Ile Glu 
865                 870                 875                 880 


Lys Glu Arg Pro Gln Leu Ala Glu Cys Glu Glu Pro Ser Ile Tyr Ser 
                885                 890                 895     


Pro Ala Phe Pro Arg Glu Lys Trp Gln Arg Lys Arg Thr Gln Val Lys 
            900                 905                 910         


Ile Arg Asn Val Thr Ser Asn His Arg Ala Ser Asp Thr Val Val Cys 
        915                 920                 925             


Glu Gly Arg Pro Gln Val Leu Ser Gly Arg Phe Met Tyr Gly Pro Leu 
    930                 935                 940                 


Asp Val Val Thr Leu Thr Gly Glu Lys Val Asp Val Tyr Ile Met Thr 
945                 950                 955                 960 


Gln Pro Leu Ser Gly Lys Trp Ile His Phe Gly Thr Glu Val Thr Asn 
                965                 970                 975     


Ser Ser Gly Arg Leu Thr Phe Pro Val Pro Pro Glu Arg Ala Leu Gly 
            980                 985                 990         


Ile Gly Val Tyr Pro Val Arg Met  Val Val Arg Gly Asp  His Thr Tyr 
        995                 1000                 1005             


Ala Glu  Cys Cys Leu Thr Val  Val Ala Arg Gly Thr  Glu Ala Val 
    1010                 1015                 1020             


Val Phe  Ser Ile Asp Gly Ser  Phe Thr Ala Ser Val  Ser Ile Met 
    1025                 1030                 1035             


Gly Ser  Asp Pro Lys Val Arg  Ala Gly Ala Val Asp  Val Val Arg 
    1040                 1045                 1050             


His Trp  Gln Asp Ser Gly Tyr  Leu Ile Val Tyr Val  Thr Gly Arg 
    1055                 1060                 1065             


Pro Asp  Met Gln Lys His Arg  Val Val Ala Trp Leu  Ser Gln His 
    1070                 1075                 1080             


Asn Phe  Pro His Gly Val Val  Ser Phe Cys Asp Gly  Leu Thr His 
    1085                 1090                 1095             


Asp Pro  Leu Arg Gln Lys Ala  Met Phe Leu Gln Ser  Leu Val Gln 
    1100                 1105                 1110             


Glu Val  Gly Leu Asn Ile Val  Ala Gly Tyr Gly Ser  Pro Lys Asp 
    1115                 1120                 1125             


Val Ala  Val Tyr Thr Ala Leu  Gly Leu Ser Pro Ser  Gln Thr Tyr 
    1130                 1135                 1140             


Ile Val  Gly Arg Ala Val Arg  Lys Leu Gln Ala Gln  Cys Gln Phe 
    1145                 1150                 1155             


Leu Ser  Asp Gly Tyr Val Ala  His Leu Gly Gln Leu  Glu Ala Gly 
    1160                 1165                 1170             


Ser His  Ser His Ala Ser Ser  Gly Pro Pro Arg Ala  Ala Leu Gly 
    1175                 1180                 1185             


Lys Ser  Ser Tyr Gly Val Ala  Ala Pro Val Asp Phe  Leu Arg Lys 
    1190                 1195                 1200             


Gln Ser  Gln Leu Leu Arg Ser  Arg Gly Pro Ser Gln  Ala Glu Arg 
    1205                 1210                 1215             


Glu Gly  Pro Gly Thr Pro Pro  Thr Thr Leu Ala Arg  Gly Lys Ala 
    1220                 1225                 1230             


Arg Ser  Ile Ser Leu Lys Leu  Asp Ser Glu Glu 
    1235                 1240                 


<210>  2800
<211>  1397
<212>  DNA
<213>  Homosapiens

<400>  2800
gcgcgcaagg caccggtggc agcggcgacg gcagctgcga cagcaacccc tgctgggccg     60

aaactgggca gagcggagca gacgtctgaa gcagcgcgag tgaggcgcga gggtagcgcc    120

cgcgcccggg aagacccctc ggcgcgaacc ggcagcccag ccccgggtcc cggttcccaa    180

ggccccgcct ctagggcctg gggactaatc ggattgagag cgcgccggcc cgggccgcga    240

actcgccaat tgcggagggc ggtggccacc gcccaatccg gagcagacag gtgcgaggtc    300

cggaaggcgg aggccaatcg gcggcggttg cgacctgctg gggcaggtct cggccaataa    360

ggaggctcga gtgacatctt cgcgcaccaa tcgggagtga gggagcattc gtgcccgctc    420

gcccttccgg ccagacctct atttaccagg ggcgtgcagc ccgcttgcca atcagagcgc    480

ggctgagcgg ccccgcagcc aacccccgag gagcggccgg ctggcgtccg ccgcgcccag    540

gagttgggga tgtcctacaa acccatcgcc cctgctccca gcagcacccc tggctccagc    600

acccctgggc cgggcacccc ggtccctaca ggaagcgtcc cgtcgccgtc gggctcagtg    660

ccaggagccg gcgctccttt cagaccgctg tttaacgact ttggaccgcc ttccatgggc    720

tacgtgcagg cgatgaagcc acccggcgcc cagggctccc agagcaccta cacggacctg    780

ctgtcagtca tagaggagat gggcaaagag atccggccta cctatgctgg cagcaagagc    840

gccatggagc gcctgaagag aggtatcatc catgcccggg ccctagtcag agagtgcctg    900

gcagagacag agcggaacgc ccgcacgtaa caggaagcgc ctcggcctca gcgtctggac    960

ctatccggcc actgcagagc acccgcttct ccctggcctt catcccgagt tgcactaacc   1020

atcctgggct tcctgtcctg tgtcccttgg tgggtcccct ccaggaacca aggagtggcc   1080

ctccaggtgg cagcactaag gacacccccc cacaacaaga gttagcagcg aggtccccat   1140

gagtcccacc catgacctgc cgacagtgtt gcccaccgga acttttgtgg cccctaccgc   1200

tcagcccttc ccagcacttc tcccactttg tcccgagcct ccttctcccc cagcaggggc   1260

acaggcctgg cacctccctg ccttgtgtcc tgagccatag tgactctttt atctgtgtgt   1320

cttttgctaa atatgccctt tttatattaa taaaagatga tttggagttg tgctctcaaa   1380

aaaaaaaaaa aaaaaaa                                                  1397


<210>  2801
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  2801

Met Ser Tyr Lys Pro Ile Ala Pro Ala Pro Ser Ser Thr Pro Gly Ser 
1               5                   10                  15      


Ser Thr Pro Gly Pro Gly Thr Pro Val Pro Thr Gly Ser Val Pro Ser 
            20                  25                  30          


Pro Ser Gly Ser Val Pro Gly Ala Gly Ala Pro Phe Arg Pro Leu Phe 
        35                  40                  45              


Asn Asp Phe Gly Pro Pro Ser Met Gly Tyr Val Gln Ala Met Lys Pro 
    50                  55                  60                  


Pro Gly Ala Gln Gly Ser Gln Ser Thr Tyr Thr Asp Leu Leu Ser Val 
65                  70                  75                  80  


Ile Glu Glu Met Gly Lys Glu Ile Arg Pro Thr Tyr Ala Gly Ser Lys 
                85                  90                  95      


Ser Ala Met Glu Arg Leu Lys Arg Gly Ile Ile His Ala Arg Ala Leu 
            100                 105                 110         


Val Arg Glu Cys Leu Ala Glu Thr Glu Arg Asn Ala Arg Thr 
        115                 120                 125     


<210>  2802
<211>  986
<212>  DNA
<213>  Homosapiens

<400>  2802
aggcagcagc atccgccgag gcccacccgg gccacccccg gggttccagg cctggcatgg     60

ttcagggccc atggggaact gtgccaagcg gccctggcgc cggggcccta aggacccctt    120

gcagtggctc ggctccccac caaggggctc ctgccccagc cccagctcca gccccaagga    180

gcagggggac cccgcgccag gcgtccaggg ctactcggtg ctcaacagcc tggtggggcc    240

tgcctgcatc ttcctgcggc ccagcattgc cgccacccaa ctcgaccggg agctgcggcc    300

cgaggagatt gaagagctgc aggtcgcctt ccaggagttt gaccgagacc aggacggcta    360

cattggctgc cgggagctgg gtgcctgcat gcggaccctg ggctacatgc ccaccgagat    420

ggagctcatc gagatctcac agcaaatcag tggcggaaag gtggactttg aagacttcgt    480

ggagctgatg ggccccaagc tgctggcaga gacggcagac atgatcggtg tccgggagct    540

acgggacgcc ttccgggagt tcgacaccaa tggggacggc cgcatcagcg tgggcgagct    600

ccgggcggcc ctcaaggccc tgctggggga gcgcctcagc cagcgggagg tggacgagat    660

cctccaggac gtggacctca atggggacgg tctggtcgac ttcgaagagt ttgtgcgaat    720

gatgtctcgg tgagcctgta cagaagctgg aggcagcata aaggactcaa ggaccacagc    780

ctctgcccac cagcatgttc cttgaagccc atcgcctcta gcggggaccc tccttttctc    840

cccatcccac ctgtgtgcag tgcccttgcc tgccttaccc ccaccaccac tttttcaata    900

aagccgcctg gccttgtctc tgtcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    960

aaaaaaaaaa aaaaaaaaaa aaaaaa                                         986


<210>  2803
<211>  220
<212>  PRT
<213>  Homosapiens

<400>  2803

Met Gly Asn Cys Ala Lys Arg Pro Trp Arg Arg Gly Pro Lys Asp Pro 
1               5                   10                  15      


Leu Gln Trp Leu Gly Ser Pro Pro Arg Gly Ser Cys Pro Ser Pro Ser 
            20                  25                  30          


Ser Ser Pro Lys Glu Gln Gly Asp Pro Ala Pro Gly Val Gln Gly Tyr 
        35                  40                  45              


Ser Val Leu Asn Ser Leu Val Gly Pro Ala Cys Ile Phe Leu Arg Pro 
    50                  55                  60                  


Ser Ile Ala Ala Thr Gln Leu Asp Arg Glu Leu Arg Pro Glu Glu Ile 
65                  70                  75                  80  


Glu Glu Leu Gln Val Ala Phe Gln Glu Phe Asp Arg Asp Gln Asp Gly 
                85                  90                  95      


Tyr Ile Gly Cys Arg Glu Leu Gly Ala Cys Met Arg Thr Leu Gly Tyr 
            100                 105                 110         


Met Pro Thr Glu Met Glu Leu Ile Glu Ile Ser Gln Gln Ile Ser Gly 
        115                 120                 125             


Gly Lys Val Asp Phe Glu Asp Phe Val Glu Leu Met Gly Pro Lys Leu 
    130                 135                 140                 


Leu Ala Glu Thr Ala Asp Met Ile Gly Val Arg Glu Leu Arg Asp Ala 
145                 150                 155                 160 


Phe Arg Glu Phe Asp Thr Asn Gly Asp Gly Arg Ile Ser Val Gly Glu 
                165                 170                 175     


Leu Arg Ala Ala Leu Lys Ala Leu Leu Gly Glu Arg Leu Ser Gln Arg 
            180                 185                 190         


Glu Val Asp Glu Ile Leu Gln Asp Val Asp Leu Asn Gly Asp Gly Leu 
        195                 200                 205             


Val Asp Phe Glu Glu Phe Val Arg Met Met Ser Arg 
    210                 215                 220 


<210>  2804
<211>  815
<212>  DNA
<213>  Homosapiens

<400>  2804
aggcagcagc atccgccgag gcccacccgg gccacccccg gggttccagg cctggcatgg     60

ttcagggccc atggggaact gtgccaagcg gccctggcgc cggggcccta aggaccggga    120

gctgcggccc gaggagattg aagagctgca ggtcgccttc caggagtttg accgagacca    180

ggacggctac attggctgcc gggagctggg tgcctgcatg cggaccctgg gctacatgcc    240

caccgagatg gagctcatcg agatctcaca gcaaatcagt ggcggaaagg tggactttga    300

agacttcgtg gagctgatgg gccccaagct gctggcagag acggcagaca tgatcggtgt    360

ccgggagcta cgggacgcct tccgggagtt cgacaccaat ggggacggcc gcatcagcgt    420

gggcgagctc cgggcggccc tcaaggccct gctgggggag cgcctcagcc agcgggaggt    480

ggacgagatc ctccaggacg tggacctcaa tggggacggt ctggtcgact tcgaagagtt    540

tgtgcgaatg atgtctcggt gagcctgtac agaagctgga ggcagcataa aggactcaag    600

gaccacagcc tctgcccacc agcatgttcc ttgaagccca tcgcctctag cggggaccct    660

ccttttctcc ccatcccacc tgtgtgcagt gcccttgcct gccttacccc caccaccact    720

ttttcaataa agccgcctgg ccttgtctct gtcaaaaaaa aaaaaaaaaa aaaaaaaaaa    780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                               815


<210>  2805
<211>  163
<212>  PRT
<213>  Homosapiens

<400>  2805

Met Gly Asn Cys Ala Lys Arg Pro Trp Arg Arg Gly Pro Lys Asp Arg 
1               5                   10                  15      


Glu Leu Arg Pro Glu Glu Ile Glu Glu Leu Gln Val Ala Phe Gln Glu 
            20                  25                  30          


Phe Asp Arg Asp Gln Asp Gly Tyr Ile Gly Cys Arg Glu Leu Gly Ala 
        35                  40                  45              


Cys Met Arg Thr Leu Gly Tyr Met Pro Thr Glu Met Glu Leu Ile Glu 
    50                  55                  60                  


Ile Ser Gln Gln Ile Ser Gly Gly Lys Val Asp Phe Glu Asp Phe Val 
65                  70                  75                  80  


Glu Leu Met Gly Pro Lys Leu Leu Ala Glu Thr Ala Asp Met Ile Gly 
                85                  90                  95      


Val Arg Glu Leu Arg Asp Ala Phe Arg Glu Phe Asp Thr Asn Gly Asp 
            100                 105                 110         


Gly Arg Ile Ser Val Gly Glu Leu Arg Ala Ala Leu Lys Ala Leu Leu 
        115                 120                 125             


Gly Glu Arg Leu Ser Gln Arg Glu Val Asp Glu Ile Leu Gln Asp Val 
    130                 135                 140                 


Asp Leu Asn Gly Asp Gly Leu Val Asp Phe Glu Glu Phe Val Arg Met 
145                 150                 155                 160 


Met Ser Arg 
            


<210>  2806
<211>  737
<212>  DNA
<213>  Homosapiens

<400>  2806
ggagtttcgc cgccgcagtc ttcgccacca tgccgcccta caccgtggtc tatttcccag     60

ttcgaggccg ctgcgcggcc ctgcgcatgc tgctggcaga tcagggccag agctggaagg    120

aggaggtggt gaccgtggag acgtggcagg agggctcact caaagcctcc tgcctatacg    180

ggcagctccc caagttccag gacggagacc tcaccctgta ccagtccaat accatcctgc    240

gtcacctggg ccgcaccctt gggctctatg ggaaggacca gcaggaggca gccctggtgg    300

acatggtgaa tgacggcgtg gaggacctcc gctgcaaata catctccctc atctacacca    360

actatgaggc gggcaaggat gactatgtga aggcactgcc cgggcaactg aagccttttg    420

agaccctgct gtcccagaac cagggaggca agaccttcat tgtgggagac cagatctcct    480

tcgctgacta caacctgctg gacttgctgc tgatccatga ggtcctagcc cctggctgcc    540

tggatgcgtt ccccctgctc tcagcatatg tggggcgcct cagcgcccgg cccaagctca    600

aggccttcct ggcctcccct gagtacgtga acctccccat caatggcaac gggaaacagt    660

gagggttggg gggactctga gcgggaggca gagtttgcct tcctttctcc aggaccaata    720

aaatttctaa gagagct                                                   737


<210>  2807
<211>  210
<212>  PRT
<213>  Homosapiens

<400>  2807

Met Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala 
1               5                   10                  15      


Ala Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu 
            20                  25                  30          


Val Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys 
        35                  40                  45              


Leu Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr 
    50                  55                  60                  


Gln Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr 
65                  70                  75                  80  


Gly Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly 
                85                  90                  95      


Val Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr 
            100                 105                 110         


Glu Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys 
        115                 120                 125             


Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile 
    130                 135                 140                 


Val Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu 
145                 150                 155                 160 


Leu Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu 
                165                 170                 175     


Leu Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala 
            180                 185                 190         


Phe Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 
        195                 200                 205             


Lys Gln 
    210 


<210>  2808
<211>  2431
<212>  DNA
<213>  Homosapiens

<400>  2808
ctctttcgct ccctccttag cccgccggct cccagccttt gatgccacaa gtaaacaaac     60

ctcgcatgtc gccttctgct gggtcctgga ggtcttggaa gcctgatgaa ctcgtctttt    120

tcagtttcct ggaaccctct gctgtggtcc tcgtgataag agtgaccttt ttggcctgct    180

ctccccagct cttttccagt cctcatgcag ggtatcagca ttgctgagtg gcctgcccag    240

gatgacacaa ctgccagaac tcggcctgag gtctcctaac aacaaatccc ccactggtcc    300

ccacccactg gagcacctac ttgccaggct tctcaagcga agaaggagat ccactctgat    360

gtcgtctccc aggagccttc tctgcagcat ctcaggtcct ggctctcacc tcctcagcac    420

ccatcccatc ctgtgtcact ctgtatatca gcctccccag ccagcctcca ggccacaagc    480

caagaggtat caagggctcc tccctgtccc actggcccca catccactgt gtctatctgg    540

tcaactttac cttccaaaca ttccctgcac agtgatagat ggctgtggcc ctgtcatctc    600

tcacctgaaa ttaacaatgt atccttgggg cctcccaccc tcacatcttg gctcctccag    660

ccccttctct gcaaacatgg aacagtggga ttattataaa tctcagaccc gttttgcccc    720

tttcctgcct gagagttttt gtggttcccc actgccctca gaacaaagct caagaccctt    780

tggcctggca ttcaaggtcc tttgtgctgc cacctgtcaa cctccccagt tccagctcct    840

ttggctttgc ccatacaagc tggatctgca ccagaggatc tgtcttcctc ccaacttggc    900

cctagtcctc ctaggagccc tttggacgtc acctccccca ggaagctttc tgcaaccacc    960

ctacaaccgt ccctataaac tttataaaac caattagtgt ggggaaaagc aagagagatc   1020

agattgttac tgtgtctgtg tagaaagaag tagacatagg agactccatt ttgttatgta   1080

ctaagaaaaa ttcttctgcc ttgagattct gtgaccttac ccccaacccc gtgctctctg   1140

aaacatgtgc tgtgtcaact cagagttgaa tggattaagg gcggtgcaag atgtgctttg   1200

ttaaacagat gcttgaaggc agcatgctcg ttaagactca tcaccactcc ctaatctcaa   1260

gtacccaggg acacaaaaac tgcggaaggc cgcagggacc tctgcctagg aaagccaggt   1320

attgtccaag gtttctcccc atgtgatagt ctgaaatatg gcctcgtggg aagggaaaga   1380

cctgaccgtc ccccagcccg acacccgtaa agggtctgtg ctgaggagga ttagtaaaag   1440

aggaaggaat gcctcttgca gttgagacaa gaggaaggca tctgtctcct gcctgtccct   1500

gggcaatgga atgtctcggt ataaaacccg attgtatgct ccatctactg agatagggaa   1560

aaaccgcctt agggctggag gtgggacctg cgggcagcaa tactgctttg taaagcattg   1620

agatgtttat gtgtatgcat atctaaaagc acagcactta atcctttaca ttgtctatga   1680

tgcaaagacc tttgttcacg tgtttgtctg ctgaccctct tcccacaatt gtcttgtgac   1740

cctgacacat ccccctcttc gagaaacacc cacagatgat caataaatac taagggaact   1800

cagaggctgg cgggatcctc catatgctga acgctggttc cccgggtccc cttatttctt   1860

tctctatact ttgtctctgt gtctttttct tttccaaatc tctcgtccca ccttacgaga   1920

aacacccaca ggtgtgtagg ggcaacccac ccctacaaat tagggaagaa gtagggggaa   1980

aagatgaaaa taaaccaagc ctgcagcata ctcagtattc atcatgaggt cagctgctct   2040

ctgacctgct tcctcatggc tggttggtgc ctgttgtccc ggagtgacaa agaccctaga   2100

ttatagctgc ccttaactgc tgtataaata acaacttgaa catgaaatgc taaattttcc   2160

ttttgaagta ttccttcaga tcctgcatgc tgataaaact actgactcaa ctggtcccca   2220

tgaggagctg gctcaccaaa gaatgcggtt tccaatccca attatttcat gccccttgct   2280

taggcaatca acaatcccaa atttccagcc ccttgccctc cacaatctcc ttaaaaaatt   2340

cagtccaaaa ctccttgggg agatggattt gaaggtctcc tcccatctcc aaacttggtg   2400

ccctgcaatc attaaactct ttctctgctg c                                  2431


<210>  2809
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  2809

Met Thr Gln Leu Pro Glu Leu Gly Leu Arg Ser Pro Asn Asn Lys Ser 
1               5                   10                  15      


Pro Thr Gly Pro His Pro Leu Glu His Leu Leu Ala Arg Leu Leu Lys 
            20                  25                  30          


Arg Arg Arg Arg Ser Thr Leu Met Ser Ser Pro Arg Ser Leu Leu Cys 
        35                  40                  45              


Ser Ile Ser Gly Pro Gly Ser His Leu Leu Ser Thr His Pro Ile Leu 
    50                  55                  60                  


Cys His Ser Val Tyr Gln Pro Pro Gln Pro Ala Ser Arg Pro Gln Ala 
65                  70                  75                  80  


Lys Arg Tyr Gln Gly Leu Leu Pro Val Pro Leu Ala Pro His Pro Leu 
                85                  90                  95      


Cys Leu Ser Gly Gln Leu Tyr Leu Pro Asn Ile Pro Cys Thr Val Ile 
            100                 105                 110         


Asp Gly Cys Gly Pro Val Ile Ser His Leu Lys Leu Thr Met Tyr Pro 
        115                 120                 125             


Trp Gly Leu Pro Pro Ser His Leu Gly Ser Ser Ser Pro Phe Ser Ala 
    130                 135                 140                 


Asn Met Glu Gln Trp Asp Tyr Tyr Lys Ser Gln Thr Arg Phe Ala Pro 
145                 150                 155                 160 


Phe Leu Pro Glu Ser Phe Cys Gly Ser Pro Leu Pro Ser Glu Gln Ser 
                165                 170                 175     


Ser Arg Pro Phe Gly Leu Ala Phe Lys Val Leu Cys Ala Ala Thr Cys 
            180                 185                 190         


Gln Pro Pro Gln Phe Gln Leu Leu Trp Leu Cys Pro Tyr Lys Leu Asp 
        195                 200                 205             


Leu His Gln Arg Ile Cys Leu Pro Pro Asn Leu Ala Leu Val Leu Leu 
    210                 215                 220                 


Gly Ala Leu Trp Thr Ser Pro Pro Pro Gly Ser Phe Leu Gln Pro Pro 
225                 230                 235                 240 


Tyr Asn Arg Pro Tyr Lys Leu Tyr Lys Thr Asn 
                245                 250     


<210>  2810
<211>  1566
<212>  DNA
<213>  Homosapiens

<400>  2810
atcgcgccag ttcctcagcc tcagtgctat gaaggtgaca gcgtgaggtg acccatctgg     60

cccgccgcga tgctggcaac acggcggctg ctcggctggt cgcttcccgc gcgggtatct    120

gtgcgtttca gcggcgacac gacagcaccc aagaaaacct catttggctc gctgaaggat    180

gaagaccgga ttttcaccaa cctgtacggc cgccatgact ggaggctgaa aggttccctg    240

agtcgaggtg actggtacaa gacaaaggag atcctgctga aggggcccga ctggatcctg    300

ggcgagatca agacatcggg tttgaggggc cgtggaggcg ctggcttccc cactggcctc    360

aagtggagct tcatgaataa gccctcagat ggcaggccca agtatctggt ggtgaacgca    420

gacgaggggg agccgggcac ctgcaaggac cgggagatct tacgccatga tcctcacaag    480

ctgctggaag gctgcctggt ggggggccgg gccatgggcg cccgcgctgc ctatatctac    540

atccgagggg aattctacaa tgaggcctcc aatctgcagg tggccatccg agaggcctat    600

gaggcaggtc tgattggcaa gaatgcttgt ggctctggct atgattttga cgtgtttgtg    660

gtgcgcgggg ctggggccta catctgtgga gaggagacag cgctcatcga gtccattgag    720

ggcaagcagg gcaagccccg cctgaagccc cccttccccg cagacgtggg agtgtttggc    780

tgccccacaa ctgtggccaa cgtggagaca gtggcagtgt cccccacaat ctgccgccgt    840

ggaggtacct ggtttgctgg ctttggcaga gaacgcaact caggcaccaa actattcaac    900

atctctggcc atgtcaacca cccttgcact gtggaggagg agatgtctgt gcccttgaaa    960

gaactgattg agaagcatgc tgggggtgtc acgggcggct gggacaacct ccttgctgtg   1020

atccctggcg gctcgtctac cccactgatc cccaagtctg tgtgtgagac ggtgctgatg   1080

gacttcgatg cgctggtgca ggcacagaca ggcctgggca cagctgcggt gatcgtcatg   1140

gaccgctcga cggacatcgt gaaagccatc gcccgcctca ttgagttcta taagcacgag   1200

agctgtggcc agtgtacccc atgccgtgag ggtgtggact ggatgaacaa ggtgatggca   1260

cgtttcgtga ggggggatgc ccggccggcc gagatcgact ccctgtggga gatcagcaag   1320

cagatagaag gccatacgat ttgtgctctg ggtgacgggg ccgcctggcc tgtgcagggt   1380

ctgatccgcc actttcggcc ggagctcgag gagcggatgc agcggtttgc ccagcagcat   1440

caggcccggc aggctgcctc ttagcccacc accctggcct gctgtcctgc gtctatccat   1500

gtggaatgct ggacaataaa gcgagtgctg cccaccctcc aaaaaaaaaa aaaaaaaaaa   1560

aaaaaa                                                              1566


<210>  2811
<211>  464
<212>  PRT
<213>  Homosapiens

<400>  2811

Met Leu Ala Thr Arg Arg Leu Leu Gly Trp Ser Leu Pro Ala Arg Val 
1               5                   10                  15      


Ser Val Arg Phe Ser Gly Asp Thr Thr Ala Pro Lys Lys Thr Ser Phe 
            20                  25                  30          


Gly Ser Leu Lys Asp Glu Asp Arg Ile Phe Thr Asn Leu Tyr Gly Arg 
        35                  40                  45              


His Asp Trp Arg Leu Lys Gly Ser Leu Ser Arg Gly Asp Trp Tyr Lys 
    50                  55                  60                  


Thr Lys Glu Ile Leu Leu Lys Gly Pro Asp Trp Ile Leu Gly Glu Ile 
65                  70                  75                  80  


Lys Thr Ser Gly Leu Arg Gly Arg Gly Gly Ala Gly Phe Pro Thr Gly 
                85                  90                  95      


Leu Lys Trp Ser Phe Met Asn Lys Pro Ser Asp Gly Arg Pro Lys Tyr 
            100                 105                 110         


Leu Val Val Asn Ala Asp Glu Gly Glu Pro Gly Thr Cys Lys Asp Arg 
        115                 120                 125             


Glu Ile Leu Arg His Asp Pro His Lys Leu Leu Glu Gly Cys Leu Val 
    130                 135                 140                 


Gly Gly Arg Ala Met Gly Ala Arg Ala Ala Tyr Ile Tyr Ile Arg Gly 
145                 150                 155                 160 


Glu Phe Tyr Asn Glu Ala Ser Asn Leu Gln Val Ala Ile Arg Glu Ala 
                165                 170                 175     


Tyr Glu Ala Gly Leu Ile Gly Lys Asn Ala Cys Gly Ser Gly Tyr Asp 
            180                 185                 190         


Phe Asp Val Phe Val Val Arg Gly Ala Gly Ala Tyr Ile Cys Gly Glu 
        195                 200                 205             


Glu Thr Ala Leu Ile Glu Ser Ile Glu Gly Lys Gln Gly Lys Pro Arg 
    210                 215                 220                 


Leu Lys Pro Pro Phe Pro Ala Asp Val Gly Val Phe Gly Cys Pro Thr 
225                 230                 235                 240 


Thr Val Ala Asn Val Glu Thr Val Ala Val Ser Pro Thr Ile Cys Arg 
                245                 250                 255     


Arg Gly Gly Thr Trp Phe Ala Gly Phe Gly Arg Glu Arg Asn Ser Gly 
            260                 265                 270         


Thr Lys Leu Phe Asn Ile Ser Gly His Val Asn His Pro Cys Thr Val 
        275                 280                 285             


Glu Glu Glu Met Ser Val Pro Leu Lys Glu Leu Ile Glu Lys His Ala 
    290                 295                 300                 


Gly Gly Val Thr Gly Gly Trp Asp Asn Leu Leu Ala Val Ile Pro Gly 
305                 310                 315                 320 


Gly Ser Ser Thr Pro Leu Ile Pro Lys Ser Val Cys Glu Thr Val Leu 
                325                 330                 335     


Met Asp Phe Asp Ala Leu Val Gln Ala Gln Thr Gly Leu Gly Thr Ala 
            340                 345                 350         


Ala Val Ile Val Met Asp Arg Ser Thr Asp Ile Val Lys Ala Ile Ala 
        355                 360                 365             


Arg Leu Ile Glu Phe Tyr Lys His Glu Ser Cys Gly Gln Cys Thr Pro 
    370                 375                 380                 


Cys Arg Glu Gly Val Asp Trp Met Asn Lys Val Met Ala Arg Phe Val 
385                 390                 395                 400 


Arg Gly Asp Ala Arg Pro Ala Glu Ile Asp Ser Leu Trp Glu Ile Ser 
                405                 410                 415     


Lys Gln Ile Glu Gly His Thr Ile Cys Ala Leu Gly Asp Gly Ala Ala 
            420                 425                 430         


Trp Pro Val Gln Gly Leu Ile Arg His Phe Arg Pro Glu Leu Glu Glu 
        435                 440                 445             


Arg Met Gln Arg Phe Ala Gln Gln His Gln Ala Arg Gln Ala Ala Ser 
    450                 455                 460                 


<210>  2812
<211>  834
<212>  DNA
<213>  Homosapiens

<400>  2812
cggccgcgca ggacttgaca tgctgcccga ctgcctgtcg gccgagggcg agctgcgctg     60

ccgccggctg ctggcagggg ccacggcccg gctccgcgcg cggcccgcgt cggccgcggt    120

gctcgtgccg ctctgctcag tgcgtggggt gccggcgctg ctgtacacgc tgcggtccag    180

ccgcctgacc gggaggcaca agggcgacgt cagtttccca ggcggcaagt gcgacccggc    240

tgaccaagat gtggtgcaca cggccctgcg ggaaacccgg gaggagctgg gcctggcagt    300

gcccgaggag cacgtgtggg gcctgctgcg gcctgtgtat gatccgcaaa aggccaccgt    360

ggtgccagtg cttgctggtg taggcccact ggatccccag agcctcaggc ccaactcgga    420

ggaggtgagc tgggggatat gagggggttg ggctgttcca gtcctctgtc taccctctct    480

gcctcctgcc tgcaggtaga tgaggtgttt gcactgccgc tggcccacct gctgcagacg    540

cagaatcagg gctataccca cttctgccgg ggtggccact tccgctacac actacccgtc    600

ttcctgcatg gaccacaccg ggtctggggc ctcacagctg tcatcactga gtttgccctg    660

cagctgctgg cacctggtac ctaccagccc cgcctggccg gcctgacctg ctcaggggct    720

gagggtctgg cccgccctaa gcagcccctg gcttcaccct gtcaggccag ctccactcca    780

ggactgaata aaggtctttg acagctctaa aaaaaaaaaa aaaaaaaaaa aaaa          834


<210>  2813
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  2813

Met Leu Pro Asp Cys Leu Ser Ala Glu Gly Glu Leu Arg Cys Arg Arg 
1               5                   10                  15      


Leu Leu Ala Gly Ala Thr Ala Arg Leu Arg Ala Arg Pro Ala Ser Ala 
            20                  25                  30          


Ala Val Leu Val Pro Leu Cys Ser Val Arg Gly Val Pro Ala Leu Leu 
        35                  40                  45              


Tyr Thr Leu Arg Ser Ser Arg Leu Thr Gly Arg His Lys Gly Asp Val 
    50                  55                  60                  


Ser Phe Pro Gly Gly Lys Cys Asp Pro Ala Asp Gln Asp Val Val His 
65                  70                  75                  80  


Thr Ala Leu Arg Glu Thr Arg Glu Glu Leu Gly Leu Ala Val Pro Glu 
                85                  90                  95      


Glu His Val Trp Gly Leu Leu Arg Pro Val Tyr Asp Pro Gln Lys Ala 
            100                 105                 110         


Thr Val Val Pro Val Leu Ala Gly Val Gly Pro Leu Asp Pro Gln Ser 
        115                 120                 125             


Leu Arg Pro Asn Ser Glu Glu Val Ser Trp Gly Ile 
    130                 135                 140 


<210>  2814
<211>  1558
<212>  DNA
<213>  Homosapiens

<400>  2814
cacgaggggt gaccacccct tccagcaggc aggttcccag ccccagccaa gcagtgtttc     60

tccaggagcc ggacagcctc tctgtctcca tggcagcctt cctatctgct ggcctcggca    120

tacttgcacc ctcagagacc taccccctac ctacaaccag ctctggctgg gagccccggc    180

tggggtcacc attcccatca ggcccttgca ccagctctac tggggcccaa gctgtggccg    240

agcccactgg gcagggcccc aagaacccac gtgtgtccag agtgacagtt cagctggaga    300

tgaagcctct gtgggaggaa ttcaaccagc tgggcactga gatgatcgtc accaaggcag    360

gcaggaggat gttccccccc ttccaggtga agatcctggg catggactcc ctggccgact    420

acgccctgct catggacttc atccccctgg acgacaagag atacaggtat gccttccaca    480

gctcggcctg gctggtggcg ggcaaggcag acccagccac acctggccgc gtgcacttcc    540

accccgactc gccagccaag ggtgcccagt ggatgcgcca gattgtgtcc tttgacaagc    600

tcaagctgac caacaacctg ctggatgaca atggccacat cattctcaac tctatgcacc    660

gctaccagcc ccgtttccac gtggtcttcg tggacccacg caaggacagt gagcgctatg    720

cccaggagaa cttcaagtcc ttcatcttca cagagaccca gttcacagca gtgacagcct    780

atcagaacca caggatcacc cagctgaaaa tcgccagcaa cccttttgcc aaaggcttta    840

gagagagtga cctggactcc tggcctgtgg ccccacggcc cctgctcagt gtcccagccc    900

ggagtcacag cagcctcagt ccctgtgtgc tgaagggtgc cacagacagg gagaaagacc    960

ccaacaaagc ttcagcttcc acctccaaga cccctgcttg gctccatcat cagctgctgc   1020

ccccacctga ggtcctgctg gccccggcca cctacaggcc tgtcacgtat cagagcctgt   1080

actctggagc cccgagccac ctagggatcc caaggacccg accagcacca taccccctcc   1140

ccaacatccg ggctgatagg gatcaaggag gcctgcctct cccagctggg ctggggctcc   1200

tgtcccccac tgtggtgtgc ctggggcctg gccaggactc ccagtgatgc cagaagccct   1260

ggggggaagc cctgctaccc tggaccttac accgggtgtg ggaatcagcc tctgccccgc   1320

cccctccagc cccatctctg tctcaaggag agcagggtag gtgaaagtct agagaaagag   1380

gctacctgcc cagggtcaca gcaaggctgg gaccatggca agcttggaac caggacttct   1440

acctcccaac cccagcagcc tgaatactgt gccctcttgc tttgggggta actcccgaaa   1500

accctgcctt acctctccct tccccctaac attaaactat ttggcatgaa aaaaaaaa     1558


<210>  2815
<211>  385
<212>  PRT
<213>  Homosapiens

<400>  2815

Met Ala Ala Phe Leu Ser Ala Gly Leu Gly Ile Leu Ala Pro Ser Glu 
1               5                   10                  15      


Thr Tyr Pro Leu Pro Thr Thr Ser Ser Gly Trp Glu Pro Arg Leu Gly 
            20                  25                  30          


Ser Pro Phe Pro Ser Gly Pro Cys Thr Ser Ser Thr Gly Ala Gln Ala 
        35                  40                  45              


Val Ala Glu Pro Thr Gly Gln Gly Pro Lys Asn Pro Arg Val Ser Arg 
    50                  55                  60                  


Val Thr Val Gln Leu Glu Met Lys Pro Leu Trp Glu Glu Phe Asn Gln 
65                  70                  75                  80  


Leu Gly Thr Glu Met Ile Val Thr Lys Ala Gly Arg Arg Met Phe Pro 
                85                  90                  95      


Pro Phe Gln Val Lys Ile Leu Gly Met Asp Ser Leu Ala Asp Tyr Ala 
            100                 105                 110         


Leu Leu Met Asp Phe Ile Pro Leu Asp Asp Lys Arg Tyr Arg Tyr Ala 
        115                 120                 125             


Phe His Ser Ser Ala Trp Leu Val Ala Gly Lys Ala Asp Pro Ala Thr 
    130                 135                 140                 


Pro Gly Arg Val His Phe His Pro Asp Ser Pro Ala Lys Gly Ala Gln 
145                 150                 155                 160 


Trp Met Arg Gln Ile Val Ser Phe Asp Lys Leu Lys Leu Thr Asn Asn 
                165                 170                 175     


Leu Leu Asp Asp Asn Gly His Ile Ile Leu Asn Ser Met His Arg Tyr 
            180                 185                 190         


Gln Pro Arg Phe His Val Val Phe Val Asp Pro Arg Lys Asp Ser Glu 
        195                 200                 205             


Arg Tyr Ala Gln Glu Asn Phe Lys Ser Phe Ile Phe Thr Glu Thr Gln 
    210                 215                 220                 


Phe Thr Ala Val Thr Ala Tyr Gln Asn His Arg Ile Thr Gln Leu Lys 
225                 230                 235                 240 


Ile Ala Ser Asn Pro Phe Ala Lys Gly Phe Arg Glu Ser Asp Leu Asp 
                245                 250                 255     


Ser Trp Pro Val Ala Pro Arg Pro Leu Leu Ser Val Pro Ala Arg Ser 
            260                 265                 270         


His Ser Ser Leu Ser Pro Cys Val Leu Lys Gly Ala Thr Asp Arg Glu 
        275                 280                 285             


Lys Asp Pro Asn Lys Ala Ser Ala Ser Thr Ser Lys Thr Pro Ala Trp 
    290                 295                 300                 


Leu His His Gln Leu Leu Pro Pro Pro Glu Val Leu Leu Ala Pro Ala 
305                 310                 315                 320 


Thr Tyr Arg Pro Val Thr Tyr Gln Ser Leu Tyr Ser Gly Ala Pro Ser 
                325                 330                 335     


His Leu Gly Ile Pro Arg Thr Arg Pro Ala Pro Tyr Pro Leu Pro Asn 
            340                 345                 350         


Ile Arg Ala Asp Arg Asp Gln Gly Gly Leu Pro Leu Pro Ala Gly Leu 
        355                 360                 365             


Gly Leu Leu Ser Pro Thr Val Val Cys Leu Gly Pro Gly Gln Asp Ser 
    370                 375                 380                 


Gln 
385 


<210>  2816
<211>  1317
<212>  DNA
<213>  Homosapiens

<400>  2816
cggagtgaca gccccacggg ccacgcagca agcagaagat ccccgggagt caccctcaac     60

cctctggggc cacgtgggcc catgaatacc agcctgtctg cgagttagac gccagtcctg    120

gtggcccggg aagcccagat ccgcatcagc ggttctgcac cccacaccag catgtgctca    180

ctgcctgtgc cccgggagcc cctgcgtcgc gtggctgtga ctgggggcac gcatggcaac    240

gagatgtcgg gcgtctacct ggcccggcac tggctgcatg cccccgcaga gctgcagaga    300

gccagcttct ccgctgtgcc tgtgctggcc aacccggcag ccacatccgg ctgccgccgc    360

tacgtggacc atgacctcaa ccgcaccttc accagcagct tcctcaattc caggcccacc    420

ccggacgacc catatgaggt gacaagagcc cgagagctga accagctgct ggggcccaag    480

gcctcgggcc aggcctttga ctttgtcctt gacctgcaca acaccacggc caacatgggc    540

acctgcttaa tcgcgaagtc ctcccacgaa gtctttgcca tgcacctgtg ccgccatctg    600

cagctgcagt accccgagct gtcctgccag gtcttcctgt accagcggtc tggggaggag    660

agctacaacc tggactctgt ggccaaaaat ggactgggtc tggagctggg cccccagcca    720

cagggtgtgc tgcgggctga cattttctca aggatgagga ccctggtggc cacagttctg    780

gacttcatcg aactcttcaa ccagggtacg gcctttcctg cctttgagat ggaagcctat    840

agacccgtgg gcgtcgtgga cttcccccgc accgaggccg ggcacctggc aggcactgtg    900

catcctcagc tgcaggaccg agacttccag ccactgcagc ctggtgctcc catcttccag    960

atgttcagtg gggaggacct gctctatgag ggagagtcca cggtgtaccc cgtgttcatt   1020

aacgaggctg cctactatga gaagggcgtt gcctttgtcc agactgagaa gttcacattc   1080

accgtgcctg ccatgcccgc gctgacccct gccccgagcc cagcttccta acccaagaca   1140

cacctcccca acctcagtct tcccatctga acgatgggtc ctgaggcaca gctctgagca   1200

cagaggtccc ttctgccacc taccatgcac catgttcctt gccaggcctc cccaacccct   1260

ggcctcaatt tccctttcta taaaatggaa gatgtccaga aaaaaaaaaa aaaaaaa      1317


<210>  2817
<211>  319
<212>  PRT
<213>  Homosapiens

<400>  2817

Met Cys Ser Leu Pro Val Pro Arg Glu Pro Leu Arg Arg Val Ala Val 
1               5                   10                  15      


Thr Gly Gly Thr His Gly Asn Glu Met Ser Gly Val Tyr Leu Ala Arg 
            20                  25                  30          


His Trp Leu His Ala Pro Ala Glu Leu Gln Arg Ala Ser Phe Ser Ala 
        35                  40                  45              


Val Pro Val Leu Ala Asn Pro Ala Ala Thr Ser Gly Cys Arg Arg Tyr 
    50                  55                  60                  


Val Asp His Asp Leu Asn Arg Thr Phe Thr Ser Ser Phe Leu Asn Ser 
65                  70                  75                  80  


Arg Pro Thr Pro Asp Asp Pro Tyr Glu Val Thr Arg Ala Arg Glu Leu 
                85                  90                  95      


Asn Gln Leu Leu Gly Pro Lys Ala Ser Gly Gln Ala Phe Asp Phe Val 
            100                 105                 110         


Leu Asp Leu His Asn Thr Thr Ala Asn Met Gly Thr Cys Leu Ile Ala 
        115                 120                 125             


Lys Ser Ser His Glu Val Phe Ala Met His Leu Cys Arg His Leu Gln 
    130                 135                 140                 


Leu Gln Tyr Pro Glu Leu Ser Cys Gln Val Phe Leu Tyr Gln Arg Ser 
145                 150                 155                 160 


Gly Glu Glu Ser Tyr Asn Leu Asp Ser Val Ala Lys Asn Gly Leu Gly 
                165                 170                 175     


Leu Glu Leu Gly Pro Gln Pro Gln Gly Val Leu Arg Ala Asp Ile Phe 
            180                 185                 190         


Ser Arg Met Arg Thr Leu Val Ala Thr Val Leu Asp Phe Ile Glu Leu 
        195                 200                 205             


Phe Asn Gln Gly Thr Ala Phe Pro Ala Phe Glu Met Glu Ala Tyr Arg 
    210                 215                 220                 


Pro Val Gly Val Val Asp Phe Pro Arg Thr Glu Ala Gly His Leu Ala 
225                 230                 235                 240 


Gly Thr Val His Pro Gln Leu Gln Asp Arg Asp Phe Gln Pro Leu Gln 
                245                 250                 255     


Pro Gly Ala Pro Ile Phe Gln Met Phe Ser Gly Glu Asp Leu Leu Tyr 
            260                 265                 270         


Glu Gly Glu Ser Thr Val Tyr Pro Val Phe Ile Asn Glu Ala Ala Tyr 
        275                 280                 285             


Tyr Glu Lys Gly Val Ala Phe Val Gln Thr Glu Lys Phe Thr Phe Thr 
    290                 295                 300                 


Val Pro Ala Met Pro Ala Leu Thr Pro Ala Pro Ser Pro Ala Ser 
305                 310                 315                 


<210>  2818
<211>  2660
<212>  DNA
<213>  Homosapiens

<400>  2818
accccattga ttaccccatt gccaggcgtg ggcacgggag ttggtttggg agctgccagt     60

ctcctgggag gatcgcagtc agcagagcag ggctgaggcc tgggggtagg agcagagcct    120

gcgcatctgg aggcagcatg tccaagaaag ggagtggagg tgcagcgaag gacccagggg    180

cagagcccac gctgggatgg accccttcga ggacacgctg cggcggctgc gtgaggcctt    240

caactgaggg cgcacgcggc cggccgagtt ccgggctgcg cagctccagg gcctgggcca    300

cttccttcaa gaaaacaagc agcttctgcg cgacgtgctg gcccaggacc tgcataagcc    360

agctttcgag gcagacatat ctgagctcat cctttgccag aacgaggttg actacgctct    420

caagaacctg caggcctgga tgaaggatga accacggtcc acgaacctgt tcatgaagct    480

ggactcggtc ttcatctgga aggaaccctt tggcctggtc ctcatcatcg caccctggaa    540

ctacccactg aacctgaccc tggtgctcct ggtgggcgcc ctcgccgcag ggagttgcgt    600

ggtgctgaag ccgtcagaaa tcagccaggg cacagagaag gtcctggctg aggtgctgcc    660

ccagtacctg gaccagagct gctttgccgt ggtgctgggc ggaccccagg agacagggca    720

gctgctagag cacaagttgg actacatctt cttcacaggg agccctcgtg tgggcaagat    780

tgtcatgact gctgccacca agcacctgac gcctgtcacc ctggagctgg ggggcaagaa    840

cccctgctac gtggacgaca actgcgaccc ccagaccgtg gccaaccgcg tggcctggtt    900

ctgctacttc aatgccggcc agacctgcgt ggcccctgac tacgtcctgt gcagccccga    960

gatgcaggag aggctgctgc ccgccctgca gagcaccatc acccgtttct atggcgacga   1020

cccccagagc tccccaaacc tgggccgcat catcaaccag aaacagttcc agcggctgcg   1080

ggcattgctg ggctgcggcc gcgtggccat tgggggccag agcaacgaga gcgatcgcta   1140

catcgccccc acggtgctgg tggacgtgca ggagacggag cctgtgatgc aggaggagat   1200

cttcgggccc atcctgccca tcgtgaacgt gcagagcgtg gacgaggcca tcaagttcat   1260

caaccggcag gagaagcccc tggccctgta cgccttctcc aacagcagcc aggttgtgaa   1320

ccagatgctg gagcggacca gcagcggcag ctttggaggc aatgagggct tcacctacat   1380

atctctgctg tccgtgccat tcgggggagt cggccacagt gggatgggcc ggtaccacgg   1440

caagttcacc ttcgacacct tctcccacca ccgcacctgc ctgctcgccc cctccggcct   1500

ggagaaatta aaggagatcc actacccacc ctataccgac tggaaccagc agctgttacg   1560

ctggggcatg ggctcccaga gctgcaccct cctgtgagcg tcccacccgc ctccaacggg   1620

tcacacagag aaacctgagt ctagccatga ggggcttatg ctcccaactc acattgttcc   1680

tccagaccgc aggttccccc agcctcaggt tgctggagct gtcacatgac tgcatcctgc   1740

ctgccagggc tgcaaagcaa ggtcttgctt ctatctgggg gacgctgctc gagagaggcc   1800

aagaggccgc agaacatgcc aggtgtcctc actcacccca ccctccccaa ttccagccct   1860

ttgccctctc ggtcagggtt ggccaggccc agtcacaggg gcagtgtcac cctggaaaat   1920

acagtgccct gccttcttag gggcatcagc cctgaacggt tgagagcgtg gagccctcca   1980

ggcctttgct ctcccctcta ggcacacgcg cacttccatc tctgccccat cccaactgca   2040

ccagcactgc ctcccccagg gatcctctca catcccacac tggtctctgc accacccctc   2100

tggttcacac cgcaccctgc actcacccac agcagctcca tccactggga aaactggggt   2160

ttgcatcact ccactgcaca gtgttagtgg gacctggggg caagtccctt gacttctctg   2220

agcctcagtt tccttatgtg aaagttgctg gaaccaaaat ggagtcactt atgccaaact   2280

ctaataaaat ggagtcgggg ggccacatag aagccctcac acacacatgc ccgtaacagg   2340

atttatcaca agacacgcct gcatgtagac cagacacagg gcgtatggaa agcacgtcct   2400

caagactgta gtattccaga tgagctgcag atgcttacct accacggccg tctccaccag   2460

aaaaccatcg ccaactcctg cgatcagctt gtgacttaca aaccttgttt aaaagctgct   2520

tacatggact tctgtccttt aaaagcttcc ccttggctgt ggccctctgt gtatgcctgg   2580

gatccttcca agcactcata gcccagatag gaatcctctg ctcctcccaa ataaattcat   2640

ctgttctgga aaaaaaaaaa                                               2660


<210>  2819
<211>  385
<212>  PRT
<213>  Homosapiens

<400>  2819

Met Lys Asp Glu Pro Arg Ser Thr Asn Leu Phe Met Lys Leu Asp Ser 
1               5                   10                  15      


Val Phe Ile Trp Lys Glu Pro Phe Gly Leu Val Leu Ile Ile Ala Pro 
            20                  25                  30          


Trp Asn Tyr Pro Leu Asn Leu Thr Leu Val Leu Leu Val Gly Ala Leu 
        35                  40                  45              


Ala Ala Gly Ser Cys Val Val Leu Lys Pro Ser Glu Ile Ser Gln Gly 
    50                  55                  60                  


Thr Glu Lys Val Leu Ala Glu Val Leu Pro Gln Tyr Leu Asp Gln Ser 
65                  70                  75                  80  


Cys Phe Ala Val Val Leu Gly Gly Pro Gln Glu Thr Gly Gln Leu Leu 
                85                  90                  95      


Glu His Lys Leu Asp Tyr Ile Phe Phe Thr Gly Ser Pro Arg Val Gly 
            100                 105                 110         


Lys Ile Val Met Thr Ala Ala Thr Lys His Leu Thr Pro Val Thr Leu 
        115                 120                 125             


Glu Leu Gly Gly Lys Asn Pro Cys Tyr Val Asp Asp Asn Cys Asp Pro 
    130                 135                 140                 


Gln Thr Val Ala Asn Arg Val Ala Trp Phe Cys Tyr Phe Asn Ala Gly 
145                 150                 155                 160 


Gln Thr Cys Val Ala Pro Asp Tyr Val Leu Cys Ser Pro Glu Met Gln 
                165                 170                 175     


Glu Arg Leu Leu Pro Ala Leu Gln Ser Thr Ile Thr Arg Phe Tyr Gly 
            180                 185                 190         


Asp Asp Pro Gln Ser Ser Pro Asn Leu Gly Arg Ile Ile Asn Gln Lys 
        195                 200                 205             


Gln Phe Gln Arg Leu Arg Ala Leu Leu Gly Cys Gly Arg Val Ala Ile 
    210                 215                 220                 


Gly Gly Gln Ser Asn Glu Ser Asp Arg Tyr Ile Ala Pro Thr Val Leu 
225                 230                 235                 240 


Val Asp Val Gln Glu Thr Glu Pro Val Met Gln Glu Glu Ile Phe Gly 
                245                 250                 255     


Pro Ile Leu Pro Ile Val Asn Val Gln Ser Val Asp Glu Ala Ile Lys 
            260                 265                 270         


Phe Ile Asn Arg Gln Glu Lys Pro Leu Ala Leu Tyr Ala Phe Ser Asn 
        275                 280                 285             


Ser Ser Gln Val Val Asn Gln Met Leu Glu Arg Thr Ser Ser Gly Ser 
    290                 295                 300                 


Phe Gly Gly Asn Glu Gly Phe Thr Tyr Ile Ser Leu Leu Ser Val Pro 
305                 310                 315                 320 


Phe Gly Gly Val Gly His Ser Gly Met Gly Arg Tyr His Gly Lys Phe 
                325                 330                 335     


Thr Phe Asp Thr Phe Ser His His Arg Thr Cys Leu Leu Ala Pro Ser 
            340                 345                 350         


Gly Leu Glu Lys Leu Lys Glu Ile His Tyr Pro Pro Tyr Thr Asp Trp 
        355                 360                 365             


Asn Gln Gln Leu Leu Arg Trp Gly Met Gly Ser Gln Ser Cys Thr Leu 
    370                 375                 380                 


Leu 
385 


<210>  2820
<211>  2504
<212>  DNA
<213>  Homosapiens

<400>  2820
gtgaagaagg atgtggttgc ttccccttcc accataactg atggacccct tcgaggacac     60

gctgcggcgg ctgcgtgagg ccttcaactg agggcgcacg cggccggccg agttccgggc    120

tgcgcagctc cagggcctgg gccacttcct tcaagaaaac aagcagcttc tgcgcgacgt    180

gctggcccag gacctgcata agccagcttt cgaggcagac atatctgagc tcatcctttg    240

ccagaacgag gttgactacg ctctcaagaa cctgcaggcc tggatgaagg atgaaccacg    300

gtccacgaac ctgttcatga agctggactc ggtcttcatc tggaaggaac cctttggcct    360

ggtcctcatc atcgcaccct ggaactaccc actgaacctg accctggtgc tcctggtggg    420

cgccctcgcc gcagggagtt gcgtggtgct gaagccgtca gaaatcagcc agggcacaga    480

gaaggtcctg gctgaggtgc tgccccagta cctggaccag agctgctttg ccgtggtgct    540

gggcggaccc caggagacag ggcagctgct agagcacaag ttggactaca tcttcttcac    600

agggagccct cgtgtgggca agattgtcat gactgctgcc accaagcacc tgacgcctgt    660

caccctggag ctggggggca agaacccctg ctacgtggac gacaactgcg acccccagac    720

cgtggccaac cgcgtggcct ggttctgcta cttcaatgcc ggccagacct gcgtggcccc    780

tgactacgtc ctgtgcagcc ccgagatgca ggagaggctg ctgcccgccc tgcagagcac    840

catcacccgt ttctatggcg acgaccccca gagctcccca aacctgggcc gcatcatcaa    900

ccagaaacag ttccagcggc tgcgggcatt gctgggctgc ggccgcgtgg ccattggggg    960

ccagagcaac gagagcgatc gctacatcgc ccccacggtg ctggtggacg tgcaggagac   1020

ggagcctgtg atgcaggagg agatcttcgg gcccatcctg cccatcgtga acgtgcagag   1080

cgtggacgag gccatcaagt tcatcaaccg gcaggagaag cccctggccc tgtacgcctt   1140

ctccaacagc agccaggttg tgaaccagat gctggagcgg accagcagcg gcagctttgg   1200

aggcaatgag ggcttcacct acatatctct gctgtccgtg ccattcgggg gagtcggcca   1260

cagtgggatg ggccggtacc acggcaagtt caccttcgac accttctccc accaccgcac   1320

ctgcctgctc gccccctccg gcctggagaa attaaaggag atccactacc caccctatac   1380

cgactggaac cagcagctgt tacgctgggg catgggctcc cagagctgca ccctcctgtg   1440

agcgtcccac ccgcctccaa cgggtcacac agagaaacct gagtctagcc atgaggggct   1500

tatgctccca actcacattg ttcctccaga ccgcaggttc ccccagcctc aggttgctgg   1560

agctgtcaca tgactgcatc ctgcctgcca gggctgcaaa gcaaggtctt gcttctatct   1620

gggggacgct gctcgagaga ggccaagagg ccgcagaaca tgccaggtgt cctcactcac   1680

cccaccctcc ccaattccag ccctttgccc tctcggtcag ggttggccag gcccagtcac   1740

aggggcagtg tcaccctgga aaatacagtg ccctgccttc ttaggggcat cagccctgaa   1800

cggttgagag cgtggagccc tccaggcctt tgctctcccc tctaggcaca cgcgcacttc   1860

catctctgcc ccatcccaac tgcaccagca ctgcctcccc cagggatcct ctcacatccc   1920

acactggtct ctgcaccacc cctctggttc acaccgcacc ctgcactcac ccacagcagc   1980

tccatccact gggaaaactg gggtttgcat cactccactg cacagtgtta gtgggacctg   2040

ggggcaagtc ccttgacttc tctgagcctc agtttcctta tgtgaaagtt gctggaacca   2100

aaatggagtc acttatgcca aactctaata aaatggagtc ggggggccac atagaagccc   2160

tcacacacac atgcccgtaa caggatttat cacaagacac gcctgcatgt agaccagaca   2220

cagggcgtat ggaaagcacg tcctcaagac tgtagtattc cagatgagct gcagatgctt   2280

acctaccacg gccgtctcca ccagaaaacc atcgccaact cctgcgatca gcttgtgact   2340

tacaaacctt gtttaaaagc tgcttacatg gacttctgtc ctttaaaagc ttccccttgg   2400

ctgtggccct ctgtgtatgc ctgggatcct tccaagcact catagcccag ataggaatcc   2460

tctgctcctc ccaaataaat tcatctgttc tggaaaaaaa aaaa                    2504


<210>  2821
<211>  385
<212>  PRT
<213>  Homosapiens

<400>  2821

Met Lys Asp Glu Pro Arg Ser Thr Asn Leu Phe Met Lys Leu Asp Ser 
1               5                   10                  15      


Val Phe Ile Trp Lys Glu Pro Phe Gly Leu Val Leu Ile Ile Ala Pro 
            20                  25                  30          


Trp Asn Tyr Pro Leu Asn Leu Thr Leu Val Leu Leu Val Gly Ala Leu 
        35                  40                  45              


Ala Ala Gly Ser Cys Val Val Leu Lys Pro Ser Glu Ile Ser Gln Gly 
    50                  55                  60                  


Thr Glu Lys Val Leu Ala Glu Val Leu Pro Gln Tyr Leu Asp Gln Ser 
65                  70                  75                  80  


Cys Phe Ala Val Val Leu Gly Gly Pro Gln Glu Thr Gly Gln Leu Leu 
                85                  90                  95      


Glu His Lys Leu Asp Tyr Ile Phe Phe Thr Gly Ser Pro Arg Val Gly 
            100                 105                 110         


Lys Ile Val Met Thr Ala Ala Thr Lys His Leu Thr Pro Val Thr Leu 
        115                 120                 125             


Glu Leu Gly Gly Lys Asn Pro Cys Tyr Val Asp Asp Asn Cys Asp Pro 
    130                 135                 140                 


Gln Thr Val Ala Asn Arg Val Ala Trp Phe Cys Tyr Phe Asn Ala Gly 
145                 150                 155                 160 


Gln Thr Cys Val Ala Pro Asp Tyr Val Leu Cys Ser Pro Glu Met Gln 
                165                 170                 175     


Glu Arg Leu Leu Pro Ala Leu Gln Ser Thr Ile Thr Arg Phe Tyr Gly 
            180                 185                 190         


Asp Asp Pro Gln Ser Ser Pro Asn Leu Gly Arg Ile Ile Asn Gln Lys 
        195                 200                 205             


Gln Phe Gln Arg Leu Arg Ala Leu Leu Gly Cys Gly Arg Val Ala Ile 
    210                 215                 220                 


Gly Gly Gln Ser Asn Glu Ser Asp Arg Tyr Ile Ala Pro Thr Val Leu 
225                 230                 235                 240 


Val Asp Val Gln Glu Thr Glu Pro Val Met Gln Glu Glu Ile Phe Gly 
                245                 250                 255     


Pro Ile Leu Pro Ile Val Asn Val Gln Ser Val Asp Glu Ala Ile Lys 
            260                 265                 270         


Phe Ile Asn Arg Gln Glu Lys Pro Leu Ala Leu Tyr Ala Phe Ser Asn 
        275                 280                 285             


Ser Ser Gln Val Val Asn Gln Met Leu Glu Arg Thr Ser Ser Gly Ser 
    290                 295                 300                 


Phe Gly Gly Asn Glu Gly Phe Thr Tyr Ile Ser Leu Leu Ser Val Pro 
305                 310                 315                 320 


Phe Gly Gly Val Gly His Ser Gly Met Gly Arg Tyr His Gly Lys Phe 
                325                 330                 335     


Thr Phe Asp Thr Phe Ser His His Arg Thr Cys Leu Leu Ala Pro Ser 
            340                 345                 350         


Gly Leu Glu Lys Leu Lys Glu Ile His Tyr Pro Pro Tyr Thr Asp Trp 
        355                 360                 365             


Asn Gln Gln Leu Leu Arg Trp Gly Met Gly Ser Gln Ser Cys Thr Leu 
    370                 375                 380                 


Leu 
385 


<210>  2822
<211>  2334
<212>  DNA
<213>  Homosapiens

<400>  2822
gtcccggccg ccgggaggaa gtggccgggc ggtcgcaggg actccggggc gaccgccgcg     60

agtccgcagt agttcgggcc atggaggcgg agccgccgct ctacccgatg gcgggggctg    120

cggggccgca gggcgacgag gacctgctcg gggtcccgga cgggcccgag gccccgctgg    180

acgagctggt gggcgcgtac cccaactaca acgaggagga ggaggagcgc cgctactacc    240

gccgcaagcg cctgggcgtg ctcaagaacg tgctggctgc cagcgccggg ggcatgctca    300

cctacggcgt ctacctgggc ctcctgcaga tgcagctgat cctgcactac gacgagacct    360

accgcgaggt gaagtatggc aacatggggc tgcccgacat cgacagcaaa atgctgatgg    420

gcatcaacgt gactcccatc gccgccctgc tctacacacc tgtgctcatc aggttttttg    480

gaacgaagtg gatgatgttc ctcgctgtgg gcatctacgc cctctttgtc tccaccaact    540

actgggagcg ctactacacg cttgtgccct cggctgtggc cctgggcatg gccatcgtgc    600

ctctttgggc ttccatgggc aactacatca ccaggatggc gcagaagtac catgagtact    660

cccactacaa ggagcaggat gggcagggga tgaagcagcg gcctccgcgg ggctcccacg    720

cgccctatct cctggtcttc caagccatct tctacagctt cttccatctg agcttcgcct    780

gcgcccagct gcccatgatt tatttcctga accactacct gtatgacctg aaccacacgc    840

tgtacaatgt gcagagctgc ggcaccaaca gccacgggat cctcagcggc ttcaacaaga    900

cggttctgcg gacgctcccg cggagcggaa acctcattgt ggtggagagc gtgctcatgg    960

cagtggcctt cctggccatg ctgctggtgc tgggtttgtg cggagccgct taccggccca   1020

cggaggagat cgatctgcgc agcgtgggct ggggcaacat cttccagctg cccttcaagc   1080

acgtgcgtga ctaccgcctg cgccacctcg tgcctttctt tatctacagc ggcttcgagg   1140

tgctctttgc ctgcactggt atcgccttgg gctatggcgt gtgctcggtg gggctggagc   1200

ggctggctta cctcctcgtg gcttacagcc tgggcgcctc agccgcctca ctcctgggcc   1260

tgctgggcct gtggctgcca cgcccggtgc ccctggtggc cggagcaggg gtgcacctgc   1320

tgctcacctt catcctcttt ttctgggccc ctgtgcctcg ggtcctgcaa cacagctgga   1380

tcctctatgt ggcagctgcc ctttggggtg tgggcagtgc cctgaacaag actggactca   1440

gcacactcct gggaatcttg tacgaagaca aggagagaca ggacttcatc ttcaccatct   1500

accactggtg gcaggctgtg gccatcttca ccgtgtacct gggctcgagc ctgcacatga   1560

aggctaagct ggcggtgctg ctggtgacgc tggtggcggc cgcggtctcc tacctgcgga   1620

tggagcagaa gctgcgccgg ggcgtggccc cgcgccagcc ccgcatcccg cggccccagc   1680

acaaggtgcg cggttaccgc tacttggagg aggacaactc ggacgagagc gacgcggagg   1740

gcgagcatgg ggacggcgcg gaggaggagg cgccgcccgc agggcccagg cctggccccg   1800

agcccgctgg actcggccgc cggccctgcc cgtacgaaca ggcgcagggg ggagacgggc   1860

cggaggagca gtgaggggcc gcctggtccc cggactcagc ctccctcctc gccggcctca   1920

gtttaccacg tctgaggtcg gggggacccc ctccgagtcc cgcgctgtct tcaaaggccc   1980

ctgtctcccc tcccccacgt tggggacgcc cctcccagag cccaggtcac ctccgggctt   2040

ccgcagcccc ctccaaggcg gagtggagcc ttgggaaccc ctcggccaag cacaggggtt   2100

cgaaaataca gctgaaaccc cgcgggccct tagcacgcgc cccagcgccg gagcacggtc   2160

agggtcttct tgcgacccgg cccgctccag atccccacag ctctcggccg cggacccggg   2220

ccgcgtgtga gcgcactttg cacctcctat ccccagggtc cgccgagagc cacgattttt   2280

tacagaaaat gagcaataaa gagattttgt actgtcaaaa aaaaaaaaaa aaaa         2334


<210>  2823
<211>  597
<212>  PRT
<213>  Homosapiens

<400>  2823

Met Glu Ala Glu Pro Pro Leu Tyr Pro Met Ala Gly Ala Ala Gly Pro 
1               5                   10                  15      


Gln Gly Asp Glu Asp Leu Leu Gly Val Pro Asp Gly Pro Glu Ala Pro 
            20                  25                  30          


Leu Asp Glu Leu Val Gly Ala Tyr Pro Asn Tyr Asn Glu Glu Glu Glu 
        35                  40                  45              


Glu Arg Arg Tyr Tyr Arg Arg Lys Arg Leu Gly Val Leu Lys Asn Val 
    50                  55                  60                  


Leu Ala Ala Ser Ala Gly Gly Met Leu Thr Tyr Gly Val Tyr Leu Gly 
65                  70                  75                  80  


Leu Leu Gln Met Gln Leu Ile Leu His Tyr Asp Glu Thr Tyr Arg Glu 
                85                  90                  95      


Val Lys Tyr Gly Asn Met Gly Leu Pro Asp Ile Asp Ser Lys Met Leu 
            100                 105                 110         


Met Gly Ile Asn Val Thr Pro Ile Ala Ala Leu Leu Tyr Thr Pro Val 
        115                 120                 125             


Leu Ile Arg Phe Phe Gly Thr Lys Trp Met Met Phe Leu Ala Val Gly 
    130                 135                 140                 


Ile Tyr Ala Leu Phe Val Ser Thr Asn Tyr Trp Glu Arg Tyr Tyr Thr 
145                 150                 155                 160 


Leu Val Pro Ser Ala Val Ala Leu Gly Met Ala Ile Val Pro Leu Trp 
                165                 170                 175     


Ala Ser Met Gly Asn Tyr Ile Thr Arg Met Ala Gln Lys Tyr His Glu 
            180                 185                 190         


Tyr Ser His Tyr Lys Glu Gln Asp Gly Gln Gly Met Lys Gln Arg Pro 
        195                 200                 205             


Pro Arg Gly Ser His Ala Pro Tyr Leu Leu Val Phe Gln Ala Ile Phe 
    210                 215                 220                 


Tyr Ser Phe Phe His Leu Ser Phe Ala Cys Ala Gln Leu Pro Met Ile 
225                 230                 235                 240 


Tyr Phe Leu Asn His Tyr Leu Tyr Asp Leu Asn His Thr Leu Tyr Asn 
                245                 250                 255     


Val Gln Ser Cys Gly Thr Asn Ser His Gly Ile Leu Ser Gly Phe Asn 
            260                 265                 270         


Lys Thr Val Leu Arg Thr Leu Pro Arg Ser Gly Asn Leu Ile Val Val 
        275                 280                 285             


Glu Ser Val Leu Met Ala Val Ala Phe Leu Ala Met Leu Leu Val Leu 
    290                 295                 300                 


Gly Leu Cys Gly Ala Ala Tyr Arg Pro Thr Glu Glu Ile Asp Leu Arg 
305                 310                 315                 320 


Ser Val Gly Trp Gly Asn Ile Phe Gln Leu Pro Phe Lys His Val Arg 
                325                 330                 335     


Asp Tyr Arg Leu Arg His Leu Val Pro Phe Phe Ile Tyr Ser Gly Phe 
            340                 345                 350         


Glu Val Leu Phe Ala Cys Thr Gly Ile Ala Leu Gly Tyr Gly Val Cys 
        355                 360                 365             


Ser Val Gly Leu Glu Arg Leu Ala Tyr Leu Leu Val Ala Tyr Ser Leu 
    370                 375                 380                 


Gly Ala Ser Ala Ala Ser Leu Leu Gly Leu Leu Gly Leu Trp Leu Pro 
385                 390                 395                 400 


Arg Pro Val Pro Leu Val Ala Gly Ala Gly Val His Leu Leu Leu Thr 
                405                 410                 415     


Phe Ile Leu Phe Phe Trp Ala Pro Val Pro Arg Val Leu Gln His Ser 
            420                 425                 430         


Trp Ile Leu Tyr Val Ala Ala Ala Leu Trp Gly Val Gly Ser Ala Leu 
        435                 440                 445             


Asn Lys Thr Gly Leu Ser Thr Leu Leu Gly Ile Leu Tyr Glu Asp Lys 
    450                 455                 460                 


Glu Arg Gln Asp Phe Ile Phe Thr Ile Tyr His Trp Trp Gln Ala Val 
465                 470                 475                 480 


Ala Ile Phe Thr Val Tyr Leu Gly Ser Ser Leu His Met Lys Ala Lys 
                485                 490                 495     


Leu Ala Val Leu Leu Val Thr Leu Val Ala Ala Ala Val Ser Tyr Leu 
            500                 505                 510         


Arg Met Glu Gln Lys Leu Arg Arg Gly Val Ala Pro Arg Gln Pro Arg 
        515                 520                 525             


Ile Pro Arg Pro Gln His Lys Val Arg Gly Tyr Arg Tyr Leu Glu Glu 
    530                 535                 540                 


Asp Asn Ser Asp Glu Ser Asp Ala Glu Gly Glu His Gly Asp Gly Ala 
545                 550                 555                 560 


Glu Glu Glu Ala Pro Pro Ala Gly Pro Arg Pro Gly Pro Glu Pro Ala 
                565                 570                 575     


Gly Leu Gly Arg Arg Pro Cys Pro Tyr Glu Gln Ala Gln Gly Gly Asp 
            580                 585                 590         


Gly Pro Glu Glu Gln 
        595         


<210>  2824
<211>  2857
<212>  DNA
<213>  Homosapiens

<400>  2824
gacatttctt aacagcaggg ccaccaggca gagcgggaca gccaggagga agggcagctt     60

ggcagagcct caggatggac ccccttgggg acacgctgcg gcgactgcgg gaggccttcc    120

acgcggggcg cacgcggcca gctgagttcc gggctgcgca gctccaaggc ctgggccgct    180

tcctgcaaga aaacaagcag cttctgcacg acgcactggc ccaggacctg cacaagtcag    240

ccttcgagtc ggaggtgtct gaggttgcca tcagccaggg cgaggtcacc ctggccctca    300

ggaacctccg ggcctggatg aaggacgagc gtgtgcccaa gaacctggcc acgcagctgg    360

actccgcctt catccggaag gagccctttg gcctggtcct catcattgcg ccctggaact    420

atccgctgaa cctgacgctg gtgcccctcg tgggagccct cgctgcaggg aactgtgtgg    480

tgctgaagcc atcggagatt agcaagaacg tcgagaagat cctggccgag gtgctgcccc    540

aatacgtgga ccagagctgc tttgctgtgg tgctgggcgg gccccaggag acggggcagc    600

tgctagagca caggttcgac tacatcttct tcacagggag ccctcgtgtg ggcaagattg    660

ttatgactgc tgccgccaag cacctgacac ctgtcaccct ggagctgggg ggcaagaacc    720

cttgctacgt ggacgacaac tgcgaccccc agaccgtggc caaccgcgtg gcctggttcc    780

gctacttcaa cgccggccag acctgcgtgg cccccgacta cgtcctatgc agccctgaga    840

tgcaggagag gctgctgcct gccctgcaga gcaccatcac ccgtttctat ggcgacgacc    900

cccagagctc cccaaacctg ggccgcatca tcaaccagaa acagttccag cggctgcggg    960

cattgctggg ctgcggccgt gtggccattg ggggccagag cgatgagagc gatcgctaca   1020

tcgcccccac ggtgctggtg gatgtgcagg agatggagcc tgtgatgcag gaggagatct   1080

tcgggcccat cctgcccatc gtgaacgtgc agagcttgga cgaggccatc gagttcatca   1140

accggcggga gaagcccctg gccctgtacg ccttctccaa cagcagccag gtggtcaagc   1200

gggtgctgac ccagaccagc agcgggggct tctgtgggaa cgacggcttc atgcacatga   1260

ccctggccag cctgcctttt ggaggagtgg gtgccagtgg gatgggccgg taccatggca   1320

agttctcctt cgacaccttc tcccaccatc gcgcctgcct cctgcgcagc ccggggatgg   1380

agaagctcaa cgccctccgc tacccgccgc aatcgccgcg ccgcctgagg atgctgctgg   1440

tggccatgga ggcccaaggc tgcagctgca cactgctctg agcccttccc caggcccagg   1500

ctgtagacca ccatgacagc tgtcgcctgc ggctggtgga gacggggcct gggctcccgg   1560

gcccgaggag gaaaaggatt gccaaggctc cagggcaccc ctcaaagcag cgcctgcctc   1620

ctccctcctg ggtcttccct ctccctgcct cagcctcctc cctcagccgc tcccaaccat   1680

gagagccgag gtgggaggca tgggaaacag tgcagtgact caccccctgc ccccgcacca   1740

accacccata ttcaggagaa gaggacagac acggcacctc tgagtcaccc ctctcctgtg   1800

gagcgggcgt ccgaggggcc ctggcatctg actcaggcca caccatggaa tcactgcatc   1860

caaggccatt cctgccctct ctgagtctca gtttttccat ttgttcagtg gagagaatta   1920

accattgata cctcctggct gggtgaggcg gctcacacct gtaatcccag cactttggga   1980

ggccgaggca ggcggatcac ctgaaatcag gagttcaaga tcagcctggc taacatggcg   2040

aaaccccgtc tctactaaaa atacaaaaat tagcctggcg tggtggcgca tgcctgtaat   2100

cccagctact caggaggcta aggcaggaga atcgcttgaa cccgggaggt ggaggttgcc   2160

gtgagctgag attgcgtcac tgaactccgg cctgggtgac agaaggaggc tctgccttaa   2220

aaaaaaaaaa aaaaaaaacc tcctgggact gttgcaagga tgaaatgaag gattgaggga   2280

ttgagggatt gctgagctgg agctccaggt gtcctatctt tctcagtggg gtggcacgga   2340

gcggggccgc ctccctcttc tctccaggca ggtggggctg tggttatgcg atagggtctc   2400

ccttccctcc agcccatgcc agaggagctt gtaactcttt atcctcatgg tgcccactac   2460

gagtcatact cttccccatg ctgctcatcc tcctgggccc catccactca gccaaagcag   2520

aatgcagggt ttcctgcctg acaacccttc tcacctccca agtcccactt ttgaacaagc   2580

tgatgattct gaaactggcc caatttccta acaagccgga tgcttgagaa acctacattt   2640

ggacaatgag aggctgctcc tgcggcctgc gggccacctc ctcttccttg gctcctgctt   2700

tctttttaga ctatatcaac ctacaacttt agtcgggaag agggacaggg gtggacctga   2760

gtttcgtctc ctgtctctct ggctgatgtc acctgaataa agccttcttc cctggcaaaa   2820

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                            2857


<210>  2825
<211>  468
<212>  PRT
<213>  Homosapiens

<400>  2825

Met Asp Pro Leu Gly Asp Thr Leu Arg Arg Leu Arg Glu Ala Phe His 
1               5                   10                  15      


Ala Gly Arg Thr Arg Pro Ala Glu Phe Arg Ala Ala Gln Leu Gln Gly 
            20                  25                  30          


Leu Gly Arg Phe Leu Gln Glu Asn Lys Gln Leu Leu His Asp Ala Leu 
        35                  40                  45              


Ala Gln Asp Leu His Lys Ser Ala Phe Glu Ser Glu Val Ser Glu Val 
    50                  55                  60                  


Ala Ile Ser Gln Gly Glu Val Thr Leu Ala Leu Arg Asn Leu Arg Ala 
65                  70                  75                  80  


Trp Met Lys Asp Glu Arg Val Pro Lys Asn Leu Ala Thr Gln Leu Asp 
                85                  90                  95      


Ser Ala Phe Ile Arg Lys Glu Pro Phe Gly Leu Val Leu Ile Ile Ala 
            100                 105                 110         


Pro Trp Asn Tyr Pro Leu Asn Leu Thr Leu Val Pro Leu Val Gly Ala 
        115                 120                 125             


Leu Ala Ala Gly Asn Cys Val Val Leu Lys Pro Ser Glu Ile Ser Lys 
    130                 135                 140                 


Asn Val Glu Lys Ile Leu Ala Glu Val Leu Pro Gln Tyr Val Asp Gln 
145                 150                 155                 160 


Ser Cys Phe Ala Val Val Leu Gly Gly Pro Gln Glu Thr Gly Gln Leu 
                165                 170                 175     


Leu Glu His Arg Phe Asp Tyr Ile Phe Phe Thr Gly Ser Pro Arg Val 
            180                 185                 190         


Gly Lys Ile Val Met Thr Ala Ala Ala Lys His Leu Thr Pro Val Thr 
        195                 200                 205             


Leu Glu Leu Gly Gly Lys Asn Pro Cys Tyr Val Asp Asp Asn Cys Asp 
    210                 215                 220                 


Pro Gln Thr Val Ala Asn Arg Val Ala Trp Phe Arg Tyr Phe Asn Ala 
225                 230                 235                 240 


Gly Gln Thr Cys Val Ala Pro Asp Tyr Val Leu Cys Ser Pro Glu Met 
                245                 250                 255     


Gln Glu Arg Leu Leu Pro Ala Leu Gln Ser Thr Ile Thr Arg Phe Tyr 
            260                 265                 270         


Gly Asp Asp Pro Gln Ser Ser Pro Asn Leu Gly Arg Ile Ile Asn Gln 
        275                 280                 285             


Lys Gln Phe Gln Arg Leu Arg Ala Leu Leu Gly Cys Gly Arg Val Ala 
    290                 295                 300                 


Ile Gly Gly Gln Ser Asp Glu Ser Asp Arg Tyr Ile Ala Pro Thr Val 
305                 310                 315                 320 


Leu Val Asp Val Gln Glu Met Glu Pro Val Met Gln Glu Glu Ile Phe 
                325                 330                 335     


Gly Pro Ile Leu Pro Ile Val Asn Val Gln Ser Leu Asp Glu Ala Ile 
            340                 345                 350         


Glu Phe Ile Asn Arg Arg Glu Lys Pro Leu Ala Leu Tyr Ala Phe Ser 
        355                 360                 365             


Asn Ser Ser Gln Val Val Lys Arg Val Leu Thr Gln Thr Ser Ser Gly 
    370                 375                 380                 


Gly Phe Cys Gly Asn Asp Gly Phe Met His Met Thr Leu Ala Ser Leu 
385                 390                 395                 400 


Pro Phe Gly Gly Val Gly Ala Ser Gly Met Gly Arg Tyr His Gly Lys 
                405                 410                 415     


Phe Ser Phe Asp Thr Phe Ser His His Arg Ala Cys Leu Leu Arg Ser 
            420                 425                 430         


Pro Gly Met Glu Lys Leu Asn Ala Leu Arg Tyr Pro Pro Gln Ser Pro 
        435                 440                 445             


Arg Arg Leu Arg Met Leu Leu Val Ala Met Glu Ala Gln Gly Cys Ser 
    450                 455                 460                 


Cys Thr Leu Leu 
465             


<210>  2826
<211>  2746
<212>  DNA
<213>  Homosapiens

<400>  2826
gacatttctt aacagcaggg ccaccaggca gagcgggaca gccaggagga agggcagctt     60

ggcagagcct caggatggac ccccttgggg acacgctgcg gcgactgcgg gaggccttcc    120

acgcggggcg cacgcggcca gctgagttcc gggctgcgca gctccaaggc ctgggccgct    180

tcctgcaaga aaacaagcag cttctgcacg acgcactggc ccaggacctg cacaaggcca    240

cgcagctgga ctccgccttc atccggaagg agccctttgg cctggtcctc atcattgcgc    300

cctggaacta tccgctgaac ctgacgctgg tgcccctcgt gggagccctc gctgcaggga    360

actgtgtggt gctgaagcca tcggagatta gcaagaacgt cgagaagatc ctggccgagg    420

tgctgcccca atacgtggac cagagctgct ttgctgtggt gctgggcggg ccccaggaga    480

cggggcagct gctagagcac aggttcgact acatcttctt cacagggagc cctcgtgtgg    540

gcaagattgt tatgactgct gccgccaagc acctgacacc tgtcaccctg gagctggggg    600

gcaagaaccc ttgctacgtg gacgacaact gcgaccccca gaccgtggcc aaccgcgtgg    660

cctggttccg ctacttcaac gccggccaga cctgcgtggc ccccgactac gtcctatgca    720

gccctgagat gcaggagagg ctgctgcctg ccctgcagag caccatcacc cgtttctatg    780

gcgacgaccc ccagagctcc ccaaacctgg gccgcatcat caaccagaaa cagttccagc    840

ggctgcgggc attgctgggc tgcggccgtg tggccattgg gggccagagc gatgagagcg    900

atcgctacat cgcccccacg gtgctggtgg atgtgcagga gatggagcct gtgatgcagg    960

aggagatctt cgggcccatc ctgcccatcg tgaacgtgca gagcttggac gaggccatcg   1020

agttcatcaa ccggcgggag aagcccctgg ccctgtacgc cttctccaac agcagccagg   1080

tggtcaagcg ggtgctgacc cagaccagca gcgggggctt ctgtgggaac gacggcttca   1140

tgcacatgac cctggccagc ctgccttttg gaggagtggg tgccagtggg atgggccggt   1200

accatggcaa gttctccttc gacaccttct cccaccatcg cgcctgcctc ctgcgcagcc   1260

cggggatgga gaagctcaac gccctccgct acccgccgca atcgccgcgc cgcctgagga   1320

tgctgctggt ggccatggag gcccaaggct gcagctgcac actgctctga gcccttcccc   1380

aggcccaggc tgtagaccac catgacagct gtcgcctgcg gctggtggag acggggcctg   1440

ggctcccggg cccgaggagg aaaaggattg ccaaggctcc agggcacccc tcaaagcagc   1500

gcctgcctcc tccctcctgg gtcttccctc tccctgcctc agcctcctcc ctcagccgct   1560

cccaaccatg agagccgagg tgggaggcat gggaaacagt gcagtgactc accccctgcc   1620

cccgcaccaa ccacccatat tcaggagaag aggacagaca cggcacctct gagtcacccc   1680

tctcctgtgg agcgggcgtc cgaggggccc tggcatctga ctcaggccac accatggaat   1740

cactgcatcc aaggccattc ctgccctctc tgagtctcag tttttccatt tgttcagtgg   1800

agagaattaa ccattgatac ctcctggctg ggtgaggcgg ctcacacctg taatcccagc   1860

actttgggag gccgaggcag gcggatcacc tgaaatcagg agttcaagat cagcctggct   1920

aacatggcga aaccccgtct ctactaaaaa tacaaaaatt agcctggcgt ggtggcgcat   1980

gcctgtaatc ccagctactc aggaggctaa ggcaggagaa tcgcttgaac ccgggaggtg   2040

gaggttgccg tgagctgaga ttgcgtcact gaactccggc ctgggtgaca gaaggaggct   2100

ctgccttaaa aaaaaaaaaa aaaaaaacct cctgggactg ttgcaaggat gaaatgaagg   2160

attgagggat tgagggattg ctgagctgga gctccaggtg tcctatcttt ctcagtgggg   2220

tggcacggag cggggccgcc tccctcttct ctccaggcag gtggggctgt ggttatgcga   2280

tagggtctcc cttccctcca gcccatgcca gaggagcttg taactcttta tcctcatggt   2340

gcccactacg agtcatactc ttccccatgc tgctcatcct cctgggcccc atccactcag   2400

ccaaagcaga atgcagggtt tcctgcctga caacccttct cacctcccaa gtcccacttt   2460

tgaacaagct gatgattctg aaactggccc aatttcctaa caagccggat gcttgagaaa   2520

cctacatttg gacaatgaga ggctgctcct gcggcctgcg ggccacctcc tcttccttgg   2580

ctcctgcttt ctttttagac tatatcaacc tacaacttta gtcgggaaga gggacagggg   2640

tggacctgag tttcgtctcc tgtctctctg gctgatgtca cctgaataaa gccttcttcc   2700

ctggcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                  2746


<210>  2827
<211>  431
<212>  PRT
<213>  Homosapiens

<400>  2827

Met Asp Pro Leu Gly Asp Thr Leu Arg Arg Leu Arg Glu Ala Phe His 
1               5                   10                  15      


Ala Gly Arg Thr Arg Pro Ala Glu Phe Arg Ala Ala Gln Leu Gln Gly 
            20                  25                  30          


Leu Gly Arg Phe Leu Gln Glu Asn Lys Gln Leu Leu His Asp Ala Leu 
        35                  40                  45              


Ala Gln Asp Leu His Lys Ala Thr Gln Leu Asp Ser Ala Phe Ile Arg 
    50                  55                  60                  


Lys Glu Pro Phe Gly Leu Val Leu Ile Ile Ala Pro Trp Asn Tyr Pro 
65                  70                  75                  80  


Leu Asn Leu Thr Leu Val Pro Leu Val Gly Ala Leu Ala Ala Gly Asn 
                85                  90                  95      


Cys Val Val Leu Lys Pro Ser Glu Ile Ser Lys Asn Val Glu Lys Ile 
            100                 105                 110         


Leu Ala Glu Val Leu Pro Gln Tyr Val Asp Gln Ser Cys Phe Ala Val 
        115                 120                 125             


Val Leu Gly Gly Pro Gln Glu Thr Gly Gln Leu Leu Glu His Arg Phe 
    130                 135                 140                 


Asp Tyr Ile Phe Phe Thr Gly Ser Pro Arg Val Gly Lys Ile Val Met 
145                 150                 155                 160 


Thr Ala Ala Ala Lys His Leu Thr Pro Val Thr Leu Glu Leu Gly Gly 
                165                 170                 175     


Lys Asn Pro Cys Tyr Val Asp Asp Asn Cys Asp Pro Gln Thr Val Ala 
            180                 185                 190         


Asn Arg Val Ala Trp Phe Arg Tyr Phe Asn Ala Gly Gln Thr Cys Val 
        195                 200                 205             


Ala Pro Asp Tyr Val Leu Cys Ser Pro Glu Met Gln Glu Arg Leu Leu 
    210                 215                 220                 


Pro Ala Leu Gln Ser Thr Ile Thr Arg Phe Tyr Gly Asp Asp Pro Gln 
225                 230                 235                 240 


Ser Ser Pro Asn Leu Gly Arg Ile Ile Asn Gln Lys Gln Phe Gln Arg 
                245                 250                 255     


Leu Arg Ala Leu Leu Gly Cys Gly Arg Val Ala Ile Gly Gly Gln Ser 
            260                 265                 270         


Asp Glu Ser Asp Arg Tyr Ile Ala Pro Thr Val Leu Val Asp Val Gln 
        275                 280                 285             


Glu Met Glu Pro Val Met Gln Glu Glu Ile Phe Gly Pro Ile Leu Pro 
    290                 295                 300                 


Ile Val Asn Val Gln Ser Leu Asp Glu Ala Ile Glu Phe Ile Asn Arg 
305                 310                 315                 320 


Arg Glu Lys Pro Leu Ala Leu Tyr Ala Phe Ser Asn Ser Ser Gln Val 
                325                 330                 335     


Val Lys Arg Val Leu Thr Gln Thr Ser Ser Gly Gly Phe Cys Gly Asn 
            340                 345                 350         


Asp Gly Phe Met His Met Thr Leu Ala Ser Leu Pro Phe Gly Gly Val 
        355                 360                 365             


Gly Ala Ser Gly Met Gly Arg Tyr His Gly Lys Phe Ser Phe Asp Thr 
    370                 375                 380                 


Phe Ser His His Arg Ala Cys Leu Leu Arg Ser Pro Gly Met Glu Lys 
385                 390                 395                 400 


Leu Asn Ala Leu Arg Tyr Pro Pro Gln Ser Pro Arg Arg Leu Arg Met 
                405                 410                 415     


Leu Leu Val Ala Met Glu Ala Gln Gly Cys Ser Cys Thr Leu Leu 
            420                 425                 430     


<210>  2828
<211>  779
<212>  DNA
<213>  Homosapiens

<400>  2828
cccgctggcc caatggcagc gtcctacagt gtagcctccg cctcccgatt gactggcctg     60

cttggcaagg caagtagcgg cggcgcttca agatgcgctg cctgaccacg cctatgctgc    120

tgcgggccct ggcccaggct gcacgtgcag gacctcctgg tggccggagc ctccacagca    180

gtgcagtggc agccacctac aagtatgtga acatgcagga tcccgagatg gacatgaagt    240

cagtgactga ccgggcagcc cgcaccctgc tgtggactga gctcttccga ggcctgggca    300

tgaccctgag ctacctgttc cgggaaccgg ccaccatcaa ctacccgttc gagaagggcc    360

cgctgagccc tcgcttccgt ggggagcatg cgctgcgccg gtacccatcc ggggaggagc    420

gttgcattgc ctgcaagctc tgcgaggcca tctgccccgc ccaggccatc accatcgagg    480

ctgagccaag agctgatggc agccgccgga ccacccgcta tgacatcgac atgaccaagt    540

gcatctactg cggcttctgc caggaggcct gtcccgtgga tgccatcgtc gagggcccca    600

actttgagtt ctccacggag acccatgagg agctgctgta caacaaggag aagttgctca    660

acaacgggga caagtgggag gccgagatcg ccgccaacat ccaggctgac tacttgtatc    720

ggtgacgccc caccggcctg cagcccctgc tgcccaataa aaccactccg accccacgg     779


<210>  2829
<211>  210
<212>  PRT
<213>  Homosapiens

<400>  2829

Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala 
1               5                   10                  15      


Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val 
            20                  25                  30          


Ala Ala Thr Tyr Lys Tyr Val Asn Met Gln Asp Pro Glu Met Asp Met 
        35                  40                  45              


Lys Ser Val Thr Asp Arg Ala Ala Arg Thr Leu Leu Trp Thr Glu Leu 
    50                  55                  60                  


Phe Arg Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu Pro Ala 
65                  70                  75                  80  


Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg Phe Arg 
                85                  90                  95      


Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg Cys Ile 
            100                 105                 110         


Ala Cys Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln Ala Ile Thr Ile 
        115                 120                 125             


Glu Ala Glu Pro Arg Ala Asp Gly Ser Arg Arg Thr Thr Arg Tyr Asp 
    130                 135                 140                 


Ile Asp Met Thr Lys Cys Ile Tyr Cys Gly Phe Cys Gln Glu Ala Cys 
145                 150                 155                 160 


Pro Val Asp Ala Ile Val Glu Gly Pro Asn Phe Glu Phe Ser Thr Glu 
                165                 170                 175     


Thr His Glu Glu Leu Leu Tyr Asn Lys Glu Lys Leu Leu Asn Asn Gly 
            180                 185                 190         


Asp Lys Trp Glu Ala Glu Ile Ala Ala Asn Ile Gln Ala Asp Tyr Leu 
        195                 200                 205             


Tyr Arg 
    210 


<210>  2830
<211>  2700
<212>  DNA
<213>  Homosapiens

<400>  2830
gcggcgccta gtcccgggct ggcgggagtg cagttctgag tcccgcccgg cgtgcgcgga     60

gcggggcagc cagcagcgga ggcgcggcgc gcagcacacc cggggaccat gggctccatg    120

ttccggagcg aggaggtggc cctggtccag ctctttctgc ccacagcggc tgcctacacc    180

tgcgtgagtc ggctgggcga gctgggcctc gtggagttca gagacctcaa cgcctcggtg    240

agcgccttcc agagacgctt tgtggttgat gttcggcgct gtgaggagct ggagaagacc    300

ttcaccttcc tgcaggagga ggtgcggcgg gctgggctgg tcctgccccc gccaaagggg    360

aggctgccgg cacccccacc ccgggacctg ctgcgcatcc aggaggagac ggagcgcctg    420

gcccaggagc tgcgggatgt gcggggcaac cagcaggccc tgcgggccca gctgcaccag    480

ctgcagctcc acgccgccgt gctacgccag ggccatgaac ctcagctggc agccgcccac    540

acagatgggg cctcagagag gacgcccctg ctccaggccc ccggggggcc gcaccaggac    600

ctgagggtca actttgtggc aggtgccgtg gagccccaca aggcccctgc cctagagcgc    660

ctgctctgga gggcctgccg cggcttcctc attgccagct tcagggagct ggagcagccg    720

ctggagcacc ccgtgacggg cgagccagcc acgtggatga ccttcctcat ctcctactgg    780

ggtgagcaga tcggacagaa gatccgcaag atcacggact gcttccactg ccacgtcttc    840

ccgtttctgc agcaggagga ggcccgcctc ggggccctgc agcagctgca acagcagagc    900

caggagctgc aggaggtcct cggggagaca gagcggttcc tgagccaggt gctaggccgg    960

gtgctgcagc tgctgccgcc agggcaggtg caggtccaca agatgaaggc cgtgtacctg   1020

gccctgaacc agtgcagcgt gagcaccacg cacaagtgcc tcattgccga ggcctggtgc   1080

tctgtgcgag acctgcccgc cctgcaggag gccctgcggg acagctcgat ggaggaggga   1140

gtgagtgccg tggctcaccg catcccctgc cgggacatgc cccccacact catccgcacc   1200

aaccgcttca cggccagctt ccagggcatc gtggatgcct acggcgtggg ccgctaccag   1260

gaggtcaacc ccgctcccta caccatcatc accttcccct tcctgtttgc tgtgatgttc   1320

ggggatgtgg gccacgggct gctcatgttc ctcttcgccc tggccatggt ccttgcggag   1380

aaccgaccgg ctgtgaaggc cgcgcagaac gagatctggc agactttctt caggggccgc   1440

tacctgctcc tgcttatggg cctgttctcc atctacaccg gcttcatcta caacgagtgc   1500

ttcagtcgcg ccaccagcat cttcccctcg ggctggagtg tggccgccat ggccaaccag   1560

tctggctgga gtgatgcatt cctggcccag cacacgatgc ttaccctgga tcccaacgtc   1620

accggtgtct tcctgggacc ctaccccttt ggcatcgatc ctatttggag cctggctgcc   1680

aaccacttga gcttcctcaa ctccttcaag atgaagatgt ccgtcatcct gggcgtcgtg   1740

cacatggcct ttggggtggt cctcggagtc ttcaaccacg tgcactttgg ccagaggcac   1800

cggctgctgc tggagacgct gccggagctc accttcctgc tgggactctt cggttacctc   1860

gtgttcctag tcatctacaa gtggctgtgt gtctgggctg ccagggccgc ctcggccccc   1920

agcatcctca tccacttcat caacatgttc ctcttctccc acagccccag caacaggctg   1980

ctctaccccc ggcaggaggt ggtccaggcc acgctggtgg tcctggcctt ggccatggtg   2040

cccatcctgc tgcttggcac acccctgcac ctgctgcacc gccaccgccg ccgcctgcgg   2100

aggaggcccg ctgaccgaca ggaggaaaac aaggccgggt tgctggacct gcctgacgca   2160

tctgtgaatg gctggagctc cgatgaggaa aaggcagggg gcctggatga tgaagaggag   2220

gccgagctcg tcccctccga ggtgctcatg caccaggcca tccacaccat cgagttctgc   2280

ctgggctgcg tctccaacac cgcctcctac ctgcgcctgt gggccctgag cctggcccac   2340

gcccagctgt ccgaggttct gtgggccatg gtgatgcgca taggcctggg cctgggccgg   2400

gaggtgggcg tggcggctgt ggtgctggtc cccatctttg ccgcctttgc cgtgatgacc   2460

gtggctatcc tgctggtgat ggagggactc tcagccttcc tgcacgccct gcggctgcac   2520

tgggtggaat tccagaacaa gttctactca ggcacgggct acaagctgag tcccttcacc   2580

ttcgctgcca cagatgacta gggcccactg caggtcctgc cagacctcct tcctgacctc   2640

tgaggcagga gaggaataaa gacggtccgc cctggcagtg aaaaaaaaaa aaaaaaaaaa   2700


<210>  2831
<211>  830
<212>  PRT
<213>  Homosapiens

<400>  2831

Met Gly Ser Met Phe Arg Ser Glu Glu Val Ala Leu Val Gln Leu Phe 
1               5                   10                  15      


Leu Pro Thr Ala Ala Ala Tyr Thr Cys Val Ser Arg Leu Gly Glu Leu 
            20                  25                  30          


Gly Leu Val Glu Phe Arg Asp Leu Asn Ala Ser Val Ser Ala Phe Gln 
        35                  40                  45              


Arg Arg Phe Val Val Asp Val Arg Arg Cys Glu Glu Leu Glu Lys Thr 
    50                  55                  60                  


Phe Thr Phe Leu Gln Glu Glu Val Arg Arg Ala Gly Leu Val Leu Pro 
65                  70                  75                  80  


Pro Pro Lys Gly Arg Leu Pro Ala Pro Pro Pro Arg Asp Leu Leu Arg 
                85                  90                  95      


Ile Gln Glu Glu Thr Glu Arg Leu Ala Gln Glu Leu Arg Asp Val Arg 
            100                 105                 110         


Gly Asn Gln Gln Ala Leu Arg Ala Gln Leu His Gln Leu Gln Leu His 
        115                 120                 125             


Ala Ala Val Leu Arg Gln Gly His Glu Pro Gln Leu Ala Ala Ala His 
    130                 135                 140                 


Thr Asp Gly Ala Ser Glu Arg Thr Pro Leu Leu Gln Ala Pro Gly Gly 
145                 150                 155                 160 


Pro His Gln Asp Leu Arg Val Asn Phe Val Ala Gly Ala Val Glu Pro 
                165                 170                 175     


His Lys Ala Pro Ala Leu Glu Arg Leu Leu Trp Arg Ala Cys Arg Gly 
            180                 185                 190         


Phe Leu Ile Ala Ser Phe Arg Glu Leu Glu Gln Pro Leu Glu His Pro 
        195                 200                 205             


Val Thr Gly Glu Pro Ala Thr Trp Met Thr Phe Leu Ile Ser Tyr Trp 
    210                 215                 220                 


Gly Glu Gln Ile Gly Gln Lys Ile Arg Lys Ile Thr Asp Cys Phe His 
225                 230                 235                 240 


Cys His Val Phe Pro Phe Leu Gln Gln Glu Glu Ala Arg Leu Gly Ala 
                245                 250                 255     


Leu Gln Gln Leu Gln Gln Gln Ser Gln Glu Leu Gln Glu Val Leu Gly 
            260                 265                 270         


Glu Thr Glu Arg Phe Leu Ser Gln Val Leu Gly Arg Val Leu Gln Leu 
        275                 280                 285             


Leu Pro Pro Gly Gln Val Gln Val His Lys Met Lys Ala Val Tyr Leu 
    290                 295                 300                 


Ala Leu Asn Gln Cys Ser Val Ser Thr Thr His Lys Cys Leu Ile Ala 
305                 310                 315                 320 


Glu Ala Trp Cys Ser Val Arg Asp Leu Pro Ala Leu Gln Glu Ala Leu 
                325                 330                 335     


Arg Asp Ser Ser Met Glu Glu Gly Val Ser Ala Val Ala His Arg Ile 
            340                 345                 350         


Pro Cys Arg Asp Met Pro Pro Thr Leu Ile Arg Thr Asn Arg Phe Thr 
        355                 360                 365             


Ala Ser Phe Gln Gly Ile Val Asp Ala Tyr Gly Val Gly Arg Tyr Gln 
    370                 375                 380                 


Glu Val Asn Pro Ala Pro Tyr Thr Ile Ile Thr Phe Pro Phe Leu Phe 
385                 390                 395                 400 


Ala Val Met Phe Gly Asp Val Gly His Gly Leu Leu Met Phe Leu Phe 
                405                 410                 415     


Ala Leu Ala Met Val Leu Ala Glu Asn Arg Pro Ala Val Lys Ala Ala 
            420                 425                 430         


Gln Asn Glu Ile Trp Gln Thr Phe Phe Arg Gly Arg Tyr Leu Leu Leu 
        435                 440                 445             


Leu Met Gly Leu Phe Ser Ile Tyr Thr Gly Phe Ile Tyr Asn Glu Cys 
    450                 455                 460                 


Phe Ser Arg Ala Thr Ser Ile Phe Pro Ser Gly Trp Ser Val Ala Ala 
465                 470                 475                 480 


Met Ala Asn Gln Ser Gly Trp Ser Asp Ala Phe Leu Ala Gln His Thr 
                485                 490                 495     


Met Leu Thr Leu Asp Pro Asn Val Thr Gly Val Phe Leu Gly Pro Tyr 
            500                 505                 510         


Pro Phe Gly Ile Asp Pro Ile Trp Ser Leu Ala Ala Asn His Leu Ser 
        515                 520                 525             


Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly Val Val 
    530                 535                 540                 


His Met Ala Phe Gly Val Val Leu Gly Val Phe Asn His Val His Phe 
545                 550                 555                 560 


Gly Gln Arg His Arg Leu Leu Leu Glu Thr Leu Pro Glu Leu Thr Phe 
                565                 570                 575     


Leu Leu Gly Leu Phe Gly Tyr Leu Val Phe Leu Val Ile Tyr Lys Trp 
            580                 585                 590         


Leu Cys Val Trp Ala Ala Arg Ala Ala Ser Ala Pro Ser Ile Leu Ile 
        595                 600                 605             


His Phe Ile Asn Met Phe Leu Phe Ser His Ser Pro Ser Asn Arg Leu 
    610                 615                 620                 


Leu Tyr Pro Arg Gln Glu Val Val Gln Ala Thr Leu Val Val Leu Ala 
625                 630                 635                 640 


Leu Ala Met Val Pro Ile Leu Leu Leu Gly Thr Pro Leu His Leu Leu 
                645                 650                 655     


His Arg His Arg Arg Arg Leu Arg Arg Arg Pro Ala Asp Arg Gln Glu 
            660                 665                 670         


Glu Asn Lys Ala Gly Leu Leu Asp Leu Pro Asp Ala Ser Val Asn Gly 
        675                 680                 685             


Trp Ser Ser Asp Glu Glu Lys Ala Gly Gly Leu Asp Asp Glu Glu Glu 
    690                 695                 700                 


Ala Glu Leu Val Pro Ser Glu Val Leu Met His Gln Ala Ile His Thr 
705                 710                 715                 720 


Ile Glu Phe Cys Leu Gly Cys Val Ser Asn Thr Ala Ser Tyr Leu Arg 
                725                 730                 735     


Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu Ser Glu Val Leu Trp 
            740                 745                 750         


Ala Met Val Met Arg Ile Gly Leu Gly Leu Gly Arg Glu Val Gly Val 
        755                 760                 765             


Ala Ala Val Val Leu Val Pro Ile Phe Ala Ala Phe Ala Val Met Thr 
    770                 775                 780                 


Val Ala Ile Leu Leu Val Met Glu Gly Leu Ser Ala Phe Leu His Ala 
785                 790                 795                 800 


Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr Ser Gly Thr 
                805                 810                 815     


Gly Tyr Lys Leu Ser Pro Phe Thr Phe Ala Ala Thr Asp Asp 
            820                 825                 830 


<210>  2832
<211>  2480
<212>  DNA
<213>  Homosapiens

<400>  2832
ggacgcccct gctccaggcc cccggggggc cgcaccagga cctgagggtc aagtgagtga     60

gggatgacct catgcccttt ctggccagcc cagaacccct ggccagtcgc tgggctgggc    120

caggctgagc tccgactcct tgtccagtgc tctccccagg ctggccccgc ctcctccttc    180

aggcccggaa cttcccacag tcccaagccc tagccctagg gggttctcct cttctggtcc    240

tgcccgggag gcctcctgcc ttcccctgtg ggcagggcca gtgtgcccaa ttgcccgatt    300

gcccgtgctg ggcagggtcc tgcccggggg gcctggtggg ggaggcaggg caggaggttg    360

gagcagccct gcccagcccc gtggccgcca gctttgtggc aggtgccgtg gagccccaca    420

aggcccctgc cctagagcgc ctgctctgga gggcctgccg cggcttcctc attgccagct    480

tcagggagct ggagcagccg ctggagcacc ccgtgacggg cgagccagcc acgtggatga    540

ccttcctcat ctcctactgg ggtgagcaga tcggacagaa gatccgcaag atcacggact    600

gcttccactg ccacgtcttc ccgtttctgc agcaggagga ggcccgcctc ggggccctgc    660

agcagctgca acagcagagc caggagctgc aggaggtcct cggggagaca gagcggttcc    720

tgagccaggt gctaggccgg gtgctgcagc tgctgccgcc agggcaggtg caggtccaca    780

agatgaaggc cgtgtacctg gccctgaacc agtgcagcgt gagcaccacg cacaagtgcc    840

tcattgccga ggcctggtgc tctgtgcgag acctgcccgc cctgcaggag gccctgcggg    900

acagctcgat ggaggaggga gtgagtgccg tggctcaccg catcccctgc cgggacatgc    960

cccccacact catccgcacc aaccgcttca cggccagctt ccagggcatc gtggatgcct   1020

acggcgtggg ccgctaccag gaggtcaacc ccgctcccta caccatcatc accttcccct   1080

tcctgtttgc tgtgatgttc ggggatgtgg gccacgggct gctcatgttc ctcttcgccc   1140

tggccatggt ccttgcggag aaccgaccgg ctgtgaaggc cgcgcagaac gagatctggc   1200

agactttctt caggggccgc tacctgctcc tgcttatggg cctgttctcc atctacaccg   1260

gcttcatcta caacgagtgc ttcagtcgcg ccaccagcat cttcccctcg ggctggagtg   1320

tggccgccat ggccaaccag tctggctgga gtgatgcatt cctggcccag cacacgatgc   1380

ttaccctgga tcccaacgtc accggtgtct tcctgggacc ctaccccttt ggcatcgatc   1440

ctatttggag cctggctgcc aaccacttga gcttcctcaa ctccttcaag atgaagatgt   1500

ccgtcatcct gggcgtcgtg cacatggcct ttggggtggt cctcggagtc ttcaaccacg   1560

tgcactttgg ccagaggcac cggctgctgc tggagacgct gccggagctc accttcctgc   1620

tgggactctt cggttacctc gtgttcctag tcatctacaa gtggctgtgt gtctgggctg   1680

ccagggccgc ctcggccccc agcatcctca tccacttcat caacatgttc ctcttctccc   1740

acagccccag caacaggctg ctctaccccc ggcaggaggt ggtccaggcc acgctggtgg   1800

tcctggcctt ggccatggtg cccatcctgc tgcttggcac acccctgcac ctgctgcacc   1860

gccaccgccg ccgcctgcgg aggaggcccg ctgaccgaca ggaggaaaac aaggccgggt   1920

tgctggacct gcctgacgca tctgtgaatg gctggagctc cgatgaggaa aaggcagggg   1980

gcctggatga tgaagaggag gccgagctcg tcccctccga ggtgctcatg caccaggcca   2040

tccacaccat cgagttctgc ctgggctgcg tctccaacac cgcctcctac ctgcgcctgt   2100

gggccctgag cctggcccac gcccagctgt ccgaggttct gtgggccatg gtgatgcgca   2160

taggcctggg cctgggccgg gaggtgggcg tggcggctgt ggtgctggtc cccatctttg   2220

ccgcctttgc cgtgatgacc gtggctatcc tgctggtgat ggagggactc tcagccttcc   2280

tgcacgccct gcggctgcac tgggtggaat tccagaacaa gttctactca ggcacgggct   2340

acaagctgag tcccttcacc ttcgctgcca cagatgacta gggcccactg caggtcctgc   2400

cagacctcct tcctgacctc tgaggcagga gaggaataaa gacggtccgc cctggcagtg   2460

aaaaaaaaaa aaaaaaaaaa                                               2480


<210>  2833
<211>  614
<212>  PRT
<213>  Homosapiens

<400>  2833

Met Thr Phe Leu Ile Ser Tyr Trp Gly Glu Gln Ile Gly Gln Lys Ile 
1               5                   10                  15      


Arg Lys Ile Thr Asp Cys Phe His Cys His Val Phe Pro Phe Leu Gln 
            20                  25                  30          


Gln Glu Glu Ala Arg Leu Gly Ala Leu Gln Gln Leu Gln Gln Gln Ser 
        35                  40                  45              


Gln Glu Leu Gln Glu Val Leu Gly Glu Thr Glu Arg Phe Leu Ser Gln 
    50                  55                  60                  


Val Leu Gly Arg Val Leu Gln Leu Leu Pro Pro Gly Gln Val Gln Val 
65                  70                  75                  80  


His Lys Met Lys Ala Val Tyr Leu Ala Leu Asn Gln Cys Ser Val Ser 
                85                  90                  95      


Thr Thr His Lys Cys Leu Ile Ala Glu Ala Trp Cys Ser Val Arg Asp 
            100                 105                 110         


Leu Pro Ala Leu Gln Glu Ala Leu Arg Asp Ser Ser Met Glu Glu Gly 
        115                 120                 125             


Val Ser Ala Val Ala His Arg Ile Pro Cys Arg Asp Met Pro Pro Thr 
    130                 135                 140                 


Leu Ile Arg Thr Asn Arg Phe Thr Ala Ser Phe Gln Gly Ile Val Asp 
145                 150                 155                 160 


Ala Tyr Gly Val Gly Arg Tyr Gln Glu Val Asn Pro Ala Pro Tyr Thr 
                165                 170                 175     


Ile Ile Thr Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Val Gly 
            180                 185                 190         


His Gly Leu Leu Met Phe Leu Phe Ala Leu Ala Met Val Leu Ala Glu 
        195                 200                 205             


Asn Arg Pro Ala Val Lys Ala Ala Gln Asn Glu Ile Trp Gln Thr Phe 
    210                 215                 220                 


Phe Arg Gly Arg Tyr Leu Leu Leu Leu Met Gly Leu Phe Ser Ile Tyr 
225                 230                 235                 240 


Thr Gly Phe Ile Tyr Asn Glu Cys Phe Ser Arg Ala Thr Ser Ile Phe 
                245                 250                 255     


Pro Ser Gly Trp Ser Val Ala Ala Met Ala Asn Gln Ser Gly Trp Ser 
            260                 265                 270         


Asp Ala Phe Leu Ala Gln His Thr Met Leu Thr Leu Asp Pro Asn Val 
        275                 280                 285             


Thr Gly Val Phe Leu Gly Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp 
    290                 295                 300                 


Ser Leu Ala Ala Asn His Leu Ser Phe Leu Asn Ser Phe Lys Met Lys 
305                 310                 315                 320 


Met Ser Val Ile Leu Gly Val Val His Met Ala Phe Gly Val Val Leu 
                325                 330                 335     


Gly Val Phe Asn His Val His Phe Gly Gln Arg His Arg Leu Leu Leu 
            340                 345                 350         


Glu Thr Leu Pro Glu Leu Thr Phe Leu Leu Gly Leu Phe Gly Tyr Leu 
        355                 360                 365             


Val Phe Leu Val Ile Tyr Lys Trp Leu Cys Val Trp Ala Ala Arg Ala 
    370                 375                 380                 


Ala Ser Ala Pro Ser Ile Leu Ile His Phe Ile Asn Met Phe Leu Phe 
385                 390                 395                 400 


Ser His Ser Pro Ser Asn Arg Leu Leu Tyr Pro Arg Gln Glu Val Val 
                405                 410                 415     


Gln Ala Thr Leu Val Val Leu Ala Leu Ala Met Val Pro Ile Leu Leu 
            420                 425                 430         


Leu Gly Thr Pro Leu His Leu Leu His Arg His Arg Arg Arg Leu Arg 
        435                 440                 445             


Arg Arg Pro Ala Asp Arg Gln Glu Glu Asn Lys Ala Gly Leu Leu Asp 
    450                 455                 460                 


Leu Pro Asp Ala Ser Val Asn Gly Trp Ser Ser Asp Glu Glu Lys Ala 
465                 470                 475                 480 


Gly Gly Leu Asp Asp Glu Glu Glu Ala Glu Leu Val Pro Ser Glu Val 
                485                 490                 495     


Leu Met His Gln Ala Ile His Thr Ile Glu Phe Cys Leu Gly Cys Val 
            500                 505                 510         


Ser Asn Thr Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His 
        515                 520                 525             


Ala Gln Leu Ser Glu Val Leu Trp Ala Met Val Met Arg Ile Gly Leu 
    530                 535                 540                 


Gly Leu Gly Arg Glu Val Gly Val Ala Ala Val Val Leu Val Pro Ile 
545                 550                 555                 560 


Phe Ala Ala Phe Ala Val Met Thr Val Ala Ile Leu Leu Val Met Glu 
                565                 570                 575     


Gly Leu Ser Ala Phe Leu His Ala Leu Arg Leu His Trp Val Glu Phe 
            580                 585                 590         


Gln Asn Lys Phe Tyr Ser Gly Thr Gly Tyr Lys Leu Ser Pro Phe Thr 
        595                 600                 605             


Phe Ala Ala Thr Asp Asp 
    610                 


<210>  2834
<211>  2733
<212>  DNA
<213>  Homosapiens

<400>  2834
ggcagaggag cgagtgcagc ggccagcagc acatccccgc tccacagtcg ccgcagtcgc     60

cgcagccgcc gccgccgccc cgcgcgccca accgccgcgg ccccctgccc cgccggcctg    120

ccagtgagag agcggcgagg gggcgcccgg ccggactctg agcctagtcc tctcgcgctg    180

cggccgcccg cgcctcctcg gccgcctgtc gggcatgaaa accaaattct gcaccggggg    240

cgaggcggag ccctcgccgc tcgggctgct gctgagctgc ggtagcggca gcgcggcccc    300

ggcgcccggc gtggggcagc agcgcgacgc cgccagcgac ctcgagtcca agcagctggg    360

cggccaacag ccgccgctcg cgctgccccc tccgccgccg ctgccgctgc cgctgccgct    420

gccccagccc ccgccgccgc agccgcccgc agacgagcag ccggagcccc ggacgcggcg    480

cagggcctat ctgtggtgca aggagttcct gcccggcgcc tggcggggcc tccgcgagga    540

cgagttccac atcagtgtca tcagaggcgg ccttagcaac atgctgttcc agtgctccct    600

acctgacacc acagccaccc ttggtgatga gcctcggaaa gtgctcctgc ggctgtatgg    660

agcgattttg cagatgaggt cctgtaataa agagggatcc gaacaagctc agaaagaaaa    720

tgaatttcaa ggggctgagg ccatggttct ggagagcgtt atgtttgcca ttctcgcaga    780

gaggtcactt gggccaaaac tctatggcat ctttccccaa ggccgactgg agcagttcat    840

cccgagccgg cgattagata ctgaagaatt aagtttgcca gatatttctg cagaaatcgc    900

cgagaaaatg gctacatttc atggtatgaa aatgccattc aataaggaac caaaatggct    960

ttttggcaca atggaaaagt atctaaagga agtgctgaga attaaattta ctgaggaatc   1020

cagaattaaa aagctccaca aattgctcag ttacaatctg cccttggaac tggaaaacct   1080

gagatcattg cttgaatcta ctccatctcc agttgtattt tgtcataatg actgtcaaga   1140

aggtaatatc ttgttgctgg aaggccgaga gaattctgaa aaacagaaac tgatgctcat   1200

tgatttcgaa tacagcagtt acaattacag gggattcgac attggaaatc acttctgtga   1260

gtggatgtat gattatagct atgaaaaata cccttttttc agagcaaaca tccggaagta   1320

tcccaccaag aaacaacagc tccattttat ttccagttac ttgcctgcat tccaaaatga   1380

ctttgaaaac ctcagtactg aagaaaaatc cattataaaa gaagaaatgt tgcttgaagt   1440

taataggttt gcccttgcat ctcatttcct ctggggactg tggtccattg tacaagccaa   1500

gatttcatct attgaatttg ggtacatgga ctacgcccaa gcaaggtttg atgcctattt   1560

ccaccagaag aggaagcttg gggtgtgact gtggggagga ctccatccac ctcatcactg   1620

gactgcatgg ggaggcagca gagcggggtc ccctctgtgc ttcgactact gctcctgtgg   1680

caggaggctt tgggtggctc actactgaac acatgtgtat gatactaaag acggtattaa   1740

aatggagcga cgtttatttc atctcttgtt tacgatttca ctaggactca gaaacgagat   1800

cgggaagcag aaatatagtg caatagtgca acatctctga atccttttaa tctagagaag   1860

gcatttcata tttgggggct aaggtttcca gtcagatgag gcaaacagca agagtaagca   1920

gtgttacttg caggtacttt ggttaatgtt gatttaaatt ttcatgaatg tgctggtgaa   1980

cactgtgacc aggcttttgt agatggcgat gtgttataga cggtgctcac tcccaaggga   2040

cagcaagtga gcagagatgt actgcaaagt cgccagtcac tgctgcaagg tggcctctgc   2100

ctggggcctc cagaagctgc tcctttaccc tcttggtccc atggctgaag ctggagcagc   2160

ggattgctct ggagcagcca aggccgccag cgtgtggagc agagctctcc cctcctgctg   2220

ggcgtgtgtg acactgatga gtttcactgt actgcatgtg acttctcccc tgcccttcct   2280

cctgatggag tgtgcagaca gccatgcgtg gccacggggg cagtgtgagg acctccctgt   2340

ctcccggctc ccctcccagg ggagccagct gcttgaccta gctctttggg cctctcctgc   2400

cctctgctct gcctggagtg tcggatcctg tgagtaggct gggcctcccc tgggcagggt   2460

tctccaaggg cccggtttcc cggcccttac ctttcctgat gcccctgaca tcatcattct   2520

tgtgggagac agcagcctgt atgtggtgtg gggcgtggat cgagtgtagc tgtgaaatcc   2580

atatatatga aatgtcctgc gggatacagt cttagctgac ttttttttac tctgaactct   2640

tatttgaatt gttttttgtg catatatttc tgctaccaca gagattgtac tatacaaata   2700

aaaaaataaa aacccaaaaa aaaaaaaaaa aaa                                2733


<210>  2835
<211>  457
<212>  PRT
<213>  Homosapiens

<400>  2835

Met Lys Thr Lys Phe Cys Thr Gly Gly Glu Ala Glu Pro Ser Pro Leu 
1               5                   10                  15      


Gly Leu Leu Leu Ser Cys Gly Ser Gly Ser Ala Ala Pro Ala Pro Gly 
            20                  25                  30          


Val Gly Gln Gln Arg Asp Ala Ala Ser Asp Leu Glu Ser Lys Gln Leu 
        35                  40                  45              


Gly Gly Gln Gln Pro Pro Leu Ala Leu Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Leu Pro Leu Pro Leu Pro Gln Pro Pro Pro Pro Gln Pro Pro Ala Asp 
65                  70                  75                  80  


Glu Gln Pro Glu Pro Arg Thr Arg Arg Arg Ala Tyr Leu Trp Cys Lys 
                85                  90                  95      


Glu Phe Leu Pro Gly Ala Trp Arg Gly Leu Arg Glu Asp Glu Phe His 
            100                 105                 110         


Ile Ser Val Ile Arg Gly Gly Leu Ser Asn Met Leu Phe Gln Cys Ser 
        115                 120                 125             


Leu Pro Asp Thr Thr Ala Thr Leu Gly Asp Glu Pro Arg Lys Val Leu 
    130                 135                 140                 


Leu Arg Leu Tyr Gly Ala Ile Leu Gln Met Arg Ser Cys Asn Lys Glu 
145                 150                 155                 160 


Gly Ser Glu Gln Ala Gln Lys Glu Asn Glu Phe Gln Gly Ala Glu Ala 
                165                 170                 175     


Met Val Leu Glu Ser Val Met Phe Ala Ile Leu Ala Glu Arg Ser Leu 
            180                 185                 190         


Gly Pro Lys Leu Tyr Gly Ile Phe Pro Gln Gly Arg Leu Glu Gln Phe 
        195                 200                 205             


Ile Pro Ser Arg Arg Leu Asp Thr Glu Glu Leu Ser Leu Pro Asp Ile 
    210                 215                 220                 


Ser Ala Glu Ile Ala Glu Lys Met Ala Thr Phe His Gly Met Lys Met 
225                 230                 235                 240 


Pro Phe Asn Lys Glu Pro Lys Trp Leu Phe Gly Thr Met Glu Lys Tyr 
                245                 250                 255     


Leu Lys Glu Val Leu Arg Ile Lys Phe Thr Glu Glu Ser Arg Ile Lys 
            260                 265                 270         


Lys Leu His Lys Leu Leu Ser Tyr Asn Leu Pro Leu Glu Leu Glu Asn 
        275                 280                 285             


Leu Arg Ser Leu Leu Glu Ser Thr Pro Ser Pro Val Val Phe Cys His 
    290                 295                 300                 


Asn Asp Cys Gln Glu Gly Asn Ile Leu Leu Leu Glu Gly Arg Glu Asn 
305                 310                 315                 320 


Ser Glu Lys Gln Lys Leu Met Leu Ile Asp Phe Glu Tyr Ser Ser Tyr 
                325                 330                 335     


Asn Tyr Arg Gly Phe Asp Ile Gly Asn His Phe Cys Glu Trp Met Tyr 
            340                 345                 350         


Asp Tyr Ser Tyr Glu Lys Tyr Pro Phe Phe Arg Ala Asn Ile Arg Lys 
        355                 360                 365             


Tyr Pro Thr Lys Lys Gln Gln Leu His Phe Ile Ser Ser Tyr Leu Pro 
    370                 375                 380                 


Ala Phe Gln Asn Asp Phe Glu Asn Leu Ser Thr Glu Glu Lys Ser Ile 
385                 390                 395                 400 


Ile Lys Glu Glu Met Leu Leu Glu Val Asn Arg Phe Ala Leu Ala Ser 
                405                 410                 415     


His Phe Leu Trp Gly Leu Trp Ser Ile Val Gln Ala Lys Ile Ser Ser 
            420                 425                 430         


Ile Glu Phe Gly Tyr Met Asp Tyr Ala Gln Ala Arg Phe Asp Ala Tyr 
        435                 440                 445             


Phe His Gln Lys Arg Lys Leu Gly Val 
    450                 455         


<210>  2836
<211>  2679
<212>  DNA
<213>  Homosapiens

<400>  2836
ggcagaggag cgagtgcagc ggccagcagc acatccccgc tccacagtcg ccgcagtcgc     60

cgcagccgcc gccgccgccc cgcgcgccca accgccgcgg ccccctgccc cgccggcctg    120

ccagtgagag agcggcgagg gggcgcccgg ccggactctg agcctagtcc tctcgcgctg    180

cggccgcccg cgcctcctcg gccgcctgtc gggcatgaaa accaaattct gcaccggggg    240

cgaggcggag ccctcgccgc tcgggctgct gctgagctgc ggtagcggca gcgcggcccc    300

ggcgcccggc gtggggcagc agcgcgacgc cgccagcgac ctcgagtcca agcagctggg    360

cggccaacag ccgccgctcg cgctgccccc tccgccgccg ctgccgctgc cgctgccgct    420

gccccagccc ccgccgccgc agccgcccgc agacgagcag ccggagcccc ggacgcggcg    480

cagggcctat ctgtggtgca aggagttcct gcccggcgcc tggcggggcc tccgcgagga    540

cgagttccac atcagtgtca tcagaggcgg ccttagcaac atgctgttcc agtgctccct    600

acctgacacc acagccaccc ttggtgatga gcctcggaaa gtgctcctgc ggctgtatgg    660

agcgattttg cagatggggg ctgaggccat ggttctggag agcgttatgt ttgccattct    720

cgcagagagg tcacttgggc caaaactcta tggcatcttt ccccaaggcc gactggagca    780

gttcatcccg agccggcgat tagatactga agaattaagt ttgccagata tttctgcaga    840

aatcgccgag aaaatggcta catttcatgg tatgaaaatg ccattcaata aggaaccaaa    900

atggcttttt ggcacaatgg aaaagtatct aaaggaagtg ctgagaatta aatttactga    960

ggaatccaga attaaaaagc tccacaaatt gctcagttac aatctgccct tggaactgga   1020

aaacctgaga tcattgcttg aatctactcc atctccagtt gtattttgtc ataatgactg   1080

tcaagaaggt aatatcttgt tgctggaagg ccgagagaat tctgaaaaac agaaactgat   1140

gctcattgat ttcgaataca gcagttacaa ttacagggga ttcgacattg gaaatcactt   1200

ctgtgagtgg atgtatgatt atagctatga aaaataccct tttttcagag caaacatccg   1260

gaagtatccc accaagaaac aacagctcca ttttatttcc agttacttgc ctgcattcca   1320

aaatgacttt gaaaacctca gtactgaaga aaaatccatt ataaaagaag aaatgttgct   1380

tgaagttaat aggtttgccc ttgcatctca tttcctctgg ggactgtggt ccattgtaca   1440

agccaagatt tcatctattg aatttgggta catggactac gcccaagcaa ggtttgatgc   1500

ctatttccac cagaagagga agcttggggt gtgactgtgg ggaggactcc atccacctca   1560

tcactggact gcatggggag gcagcagagc ggggtcccct ctgtgcttcg actactgctc   1620

ctgtggcagg aggctttggg tggctcacta ctgaacacat gtgtatgata ctaaagacgg   1680

tattaaaatg gagcgacgtt tatttcatct cttgtttacg atttcactag gactcagaaa   1740

cgagatcggg aagcagaaat atagtgcaat agtgcaacat ctctgaatcc ttttaatcta   1800

gagaaggcat ttcatatttg ggggctaagg tttccagtca gatgaggcaa acagcaagag   1860

taagcagtgt tacttgcagg tactttggtt aatgttgatt taaattttca tgaatgtgct   1920

ggtgaacact gtgaccaggc ttttgtagat ggcgatgtgt tatagacggt gctcactccc   1980

aagggacagc aagtgagcag agatgtactg caaagtcgcc agtcactgct gcaaggtggc   2040

ctctgcctgg ggcctccaga agctgctcct ttaccctctt ggtcccatgg ctgaagctgg   2100

agcagcggat tgctctggag cagccaaggc cgccagcgtg tggagcagag ctctcccctc   2160

ctgctgggcg tgtgtgacac tgatgagttt cactgtactg catgtgactt ctcccctgcc   2220

cttcctcctg atggagtgtg cagacagcca tgcgtggcca cgggggcagt gtgaggacct   2280

ccctgtctcc cggctcccct cccaggggag ccagctgctt gacctagctc tttgggcctc   2340

tcctgccctc tgctctgcct ggagtgtcgg atcctgtgag taggctgggc ctcccctggg   2400

cagggttctc caagggcccg gtttcccggc ccttaccttt cctgatgccc ctgacatcat   2460

cattcttgtg ggagacagca gcctgtatgt ggtgtggggc gtggatcgag tgtagctgtg   2520

aaatccatat atatgaaatg tcctgcggga tacagtctta gctgactttt ttttactctg   2580

aactcttatt tgaattgttt tttgtgcata tatttctgct accacagaga ttgtactata   2640

caaataaaaa aataaaaacc caaaaaaaaa aaaaaaaaa                          2679


<210>  2837
<211>  439
<212>  PRT
<213>  Homosapiens

<400>  2837

Met Lys Thr Lys Phe Cys Thr Gly Gly Glu Ala Glu Pro Ser Pro Leu 
1               5                   10                  15      


Gly Leu Leu Leu Ser Cys Gly Ser Gly Ser Ala Ala Pro Ala Pro Gly 
            20                  25                  30          


Val Gly Gln Gln Arg Asp Ala Ala Ser Asp Leu Glu Ser Lys Gln Leu 
        35                  40                  45              


Gly Gly Gln Gln Pro Pro Leu Ala Leu Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Leu Pro Leu Pro Leu Pro Gln Pro Pro Pro Pro Gln Pro Pro Ala Asp 
65                  70                  75                  80  


Glu Gln Pro Glu Pro Arg Thr Arg Arg Arg Ala Tyr Leu Trp Cys Lys 
                85                  90                  95      


Glu Phe Leu Pro Gly Ala Trp Arg Gly Leu Arg Glu Asp Glu Phe His 
            100                 105                 110         


Ile Ser Val Ile Arg Gly Gly Leu Ser Asn Met Leu Phe Gln Cys Ser 
        115                 120                 125             


Leu Pro Asp Thr Thr Ala Thr Leu Gly Asp Glu Pro Arg Lys Val Leu 
    130                 135                 140                 


Leu Arg Leu Tyr Gly Ala Ile Leu Gln Met Gly Ala Glu Ala Met Val 
145                 150                 155                 160 


Leu Glu Ser Val Met Phe Ala Ile Leu Ala Glu Arg Ser Leu Gly Pro 
                165                 170                 175     


Lys Leu Tyr Gly Ile Phe Pro Gln Gly Arg Leu Glu Gln Phe Ile Pro 
            180                 185                 190         


Ser Arg Arg Leu Asp Thr Glu Glu Leu Ser Leu Pro Asp Ile Ser Ala 
        195                 200                 205             


Glu Ile Ala Glu Lys Met Ala Thr Phe His Gly Met Lys Met Pro Phe 
    210                 215                 220                 


Asn Lys Glu Pro Lys Trp Leu Phe Gly Thr Met Glu Lys Tyr Leu Lys 
225                 230                 235                 240 


Glu Val Leu Arg Ile Lys Phe Thr Glu Glu Ser Arg Ile Lys Lys Leu 
                245                 250                 255     


His Lys Leu Leu Ser Tyr Asn Leu Pro Leu Glu Leu Glu Asn Leu Arg 
            260                 265                 270         


Ser Leu Leu Glu Ser Thr Pro Ser Pro Val Val Phe Cys His Asn Asp 
        275                 280                 285             


Cys Gln Glu Gly Asn Ile Leu Leu Leu Glu Gly Arg Glu Asn Ser Glu 
    290                 295                 300                 


Lys Gln Lys Leu Met Leu Ile Asp Phe Glu Tyr Ser Ser Tyr Asn Tyr 
305                 310                 315                 320 


Arg Gly Phe Asp Ile Gly Asn His Phe Cys Glu Trp Met Tyr Asp Tyr 
                325                 330                 335     


Ser Tyr Glu Lys Tyr Pro Phe Phe Arg Ala Asn Ile Arg Lys Tyr Pro 
            340                 345                 350         


Thr Lys Lys Gln Gln Leu His Phe Ile Ser Ser Tyr Leu Pro Ala Phe 
        355                 360                 365             


Gln Asn Asp Phe Glu Asn Leu Ser Thr Glu Glu Lys Ser Ile Ile Lys 
    370                 375                 380                 


Glu Glu Met Leu Leu Glu Val Asn Arg Phe Ala Leu Ala Ser His Phe 
385                 390                 395                 400 


Leu Trp Gly Leu Trp Ser Ile Val Gln Ala Lys Ile Ser Ser Ile Glu 
                405                 410                 415     


Phe Gly Tyr Met Asp Tyr Ala Gln Ala Arg Phe Asp Ala Tyr Phe His 
            420                 425                 430         


Gln Lys Arg Lys Leu Gly Val 
        435                 


<210>  2838
<211>  2711
<212>  DNA
<213>  Homosapiens

<400>  2838
ggtgctgcgg cccgcgccgc catcttggat tttactctcc atttttctct ggaattattt     60

ttggtgatta attttctggg ggggactggg acgcggggcc cggcggcgcg gccccgcatc    120

gcagcggccg ggcagcgggg cctgggacgc gccccgagga ggagcggggc ggcgcaggcg    180

gagagaacat tgaaagtatt ctctaagcta tttgaagaga gtgactaaat gcacctgggt    240

caggctgtct gtgggtatga agtggttggg agaatccaag aacatggtgg tgaatggcag    300

gagaaatgga ggcaagttgt ctaatgacca tcagcagaat caatcaaaat tacagcacac    360

ggggaaggac accctgaagg ctggcaaaaa tgcagtcgag aggaggtcga acagatgtaa    420

tggtaactcg ggatttgaag gacagagtcg ctatgtacca tcctctggaa tgtccgccaa    480

ggaactctgt gaaaatgatg acctagcaac cagtttggtt cttgatccct atttaggttt    540

tcaaacacac aaaatgaata ctagcgcctt tccttcgagg agctcaaggc atttttcaaa    600

atctgacagt ttttctcaca acaaccctgt gagatttagg cctattaaag gaaggcagga    660

agaactaaag gaagtaattg aacgttttaa gaaagatgaa cacttggaga aagccttcaa    720

atgtttgact tcaggcgaat gggcacggca ctattttctc aacaagaata aaatgcagga    780

gaaattattc aaagaacatg tatttattta tttgcgaatg tttgcaactg acagtggatt    840

tgaaatattg ccatgtaata gatactcatc agaacaaaat ggagccaaaa tagttgcaac    900

aaaagagtgg aaacgaaatg acaaaataga attactggtg ggttgtattg ccgaactttc    960

agaaattgag gagaacatgc tacttagaca tggagaaaac gacttcagtg tcatgtactc   1020

cacaaggaaa aactgtgctc aactctggct gggtcctgct gcgtttataa accatgattg   1080

cagacctaat tgtaagtttg tgtcaactgg tcgagataca gcatgtgtga aggctctaag   1140

agacattgaa cctggagaag aaatttcttg ttattatgga gatgggttct ttggagaaaa   1200

taatgagttc tgcgagtgtt acacttgcga aagacggggc actggtgctt ttaaatccag   1260

agtgggactg cctgcgcctg ctcctgttat caatagcaaa tatggactca gagaaacaga   1320

taaacgttta aataggctta aaaagttagg tgacagcagc aaaaattcag acagtcaatc   1380

tgtcagctct aacactgatg cagataccac tcaggaaaaa aacaatgcaa gtaagtaagg   1440

gagatttgat aagcatatct tttaaaagta ttttcacaca atttgcttta taaagtgtgc   1500

ttcagtagtt ttaaactttt aaatactcag agagactggg acttgtgagc tttggctgca   1560

cttcaaggct ctagacgtga tttgagtaga ggcacagtct gtatcccatc tctaacttca   1620

gtaccgtcct ctagactatt tttcttgaat accttggtaa ctggatatga gttcttcatc   1680

atatgttcca aggtcatcat atgttttaaa cattttcaag gtgttagaga ctgtgatgat   1740

gtcgctaagt cctgcaagaa gacaaaagga ctgagtagaa ttaaattaga ctctatacat   1800

tccagtgcct agccagtttg ttagaaaaga tgatggactt ggggaattca tagcttctgg   1860

ccttaaggct tccacctttt cattgcttgc tgaccttttt caaaacgaac tgactcagtt   1920

cagcagacca ccagtaccag actcagaatt gtgatagagg agcattttga acagtgccgt   1980

attgtgacat gctgtattgg ctactccaga aagtaggagt aaagatggaa aggagaaaga   2040

agcaacctct gagattccag tggtgtgtgg gggcaagatc tgatggaaac tgaaaaagag   2100

aacgaagact aaacaaagag aaaggaaaga gaagaaaccc taaatgggca aaggaaagca   2160

catcctgttt gcggagcttt gaaatattgg aaccatttct aattgctcct gtttttctgg   2220

gtaacaccag ttttctgtag ttgccactaa agcagtagac tcttgagtct cacttgtctc   2280

tgagagagac agaagttaga aagttttgac ttggcgattc cgaaagtatg cctttgttgg   2340

cacttaaatg tccagtgaga cttcttggca ccttagagcc ctctgagata ctgattattt   2400

taggttcttc tccctacttt cagatgtttt cagcccaaca ctgggtgctc tcttccacta   2460

cagagaatcc tgaagaaaag ggaaggtgtt tcccatgatg gtgaatgtca ctgccatgaa   2520

ttcctgaatc tacctgctgc tgggagtcag agtccaagca taacccgtgt agcataaaag   2580

cagcgctgta gccctattcc agtctttttc gttaatgtcc agagtgaaca acaagagtta   2640

gtcaatcatt aactgttgac tgttgattct cataataaat gcagcataac gacaaaaaaa   2700

aaaaaaaaaa a                                                        2711


<210>  2839
<211>  393
<212>  PRT
<213>  Homosapiens

<400>  2839

Met Lys Trp Leu Gly Glu Ser Lys Asn Met Val Val Asn Gly Arg Arg 
1               5                   10                  15      


Asn Gly Gly Lys Leu Ser Asn Asp His Gln Gln Asn Gln Ser Lys Leu 
            20                  25                  30          


Gln His Thr Gly Lys Asp Thr Leu Lys Ala Gly Lys Asn Ala Val Glu 
        35                  40                  45              


Arg Arg Ser Asn Arg Cys Asn Gly Asn Ser Gly Phe Glu Gly Gln Ser 
    50                  55                  60                  


Arg Tyr Val Pro Ser Ser Gly Met Ser Ala Lys Glu Leu Cys Glu Asn 
65                  70                  75                  80  


Asp Asp Leu Ala Thr Ser Leu Val Leu Asp Pro Tyr Leu Gly Phe Gln 
                85                  90                  95      


Thr His Lys Met Asn Thr Ser Ala Phe Pro Ser Arg Ser Ser Arg His 
            100                 105                 110         


Phe Ser Lys Ser Asp Ser Phe Ser His Asn Asn Pro Val Arg Phe Arg 
        115                 120                 125             


Pro Ile Lys Gly Arg Gln Glu Glu Leu Lys Glu Val Ile Glu Arg Phe 
    130                 135                 140                 


Lys Lys Asp Glu His Leu Glu Lys Ala Phe Lys Cys Leu Thr Ser Gly 
145                 150                 155                 160 


Glu Trp Ala Arg His Tyr Phe Leu Asn Lys Asn Lys Met Gln Glu Lys 
                165                 170                 175     


Leu Phe Lys Glu His Val Phe Ile Tyr Leu Arg Met Phe Ala Thr Asp 
            180                 185                 190         


Ser Gly Phe Glu Ile Leu Pro Cys Asn Arg Tyr Ser Ser Glu Gln Asn 
        195                 200                 205             


Gly Ala Lys Ile Val Ala Thr Lys Glu Trp Lys Arg Asn Asp Lys Ile 
    210                 215                 220                 


Glu Leu Leu Val Gly Cys Ile Ala Glu Leu Ser Glu Ile Glu Glu Asn 
225                 230                 235                 240 


Met Leu Leu Arg His Gly Glu Asn Asp Phe Ser Val Met Tyr Ser Thr 
                245                 250                 255     


Arg Lys Asn Cys Ala Gln Leu Trp Leu Gly Pro Ala Ala Phe Ile Asn 
            260                 265                 270         


His Asp Cys Arg Pro Asn Cys Lys Phe Val Ser Thr Gly Arg Asp Thr 
        275                 280                 285             


Ala Cys Val Lys Ala Leu Arg Asp Ile Glu Pro Gly Glu Glu Ile Ser 
    290                 295                 300                 


Cys Tyr Tyr Gly Asp Gly Phe Phe Gly Glu Asn Asn Glu Phe Cys Glu 
305                 310                 315                 320 


Cys Tyr Thr Cys Glu Arg Arg Gly Thr Gly Ala Phe Lys Ser Arg Val 
                325                 330                 335     


Gly Leu Pro Ala Pro Ala Pro Val Ile Asn Ser Lys Tyr Gly Leu Arg 
            340                 345                 350         


Glu Thr Asp Lys Arg Leu Asn Arg Leu Lys Lys Leu Gly Asp Ser Ser 
        355                 360                 365             


Lys Asn Ser Asp Ser Gln Ser Val Ser Ser Asn Thr Asp Ala Asp Thr 
    370                 375                 380                 


Thr Gln Glu Lys Asn Asn Ala Ser Lys 
385                 390             


<210>  2840
<211>  4562
<212>  DNA
<213>  Homosapiens

<400>  2840
ggtgctgcgg cccgcgccgc catcttggat tttactctcc atttttctct ggaattattt     60

ttggtgatta attttctggg ggggactggg acgcggggcc cggcggcgcg gccccgcatc    120

gcagcggccg ggcagcgggg cctgggacgc gccccgagga ggagcggggc ggcgcaggcg    180

gagagaacat tgaaagtatt ctctaagcta tttgaagaga gtgactaaat gcacctgggt    240

caggctgtct gtgggtatga agtggttggg agaatccaag aacatggtgg tgaatggcag    300

gagaaatgga ggcaagttgt ctaatgacca tcagcagaat caatcaaaat tacagcacac    360

ggggaaggac accctgaagg ctggcaaaaa tgcagtcgag aggaggtcga acagatgtaa    420

tggtaactcg ggatttgaag gacagagtcg ctatgtacca tcctctggaa tgtccgccaa    480

ggaactctgt gaaaatgatg acctagcaac cagtttggtt cttgatccct atttaggttt    540

tcaaacacac aaaatgaata ctagcgcctt tccttcgagg agctcaaggc atttttcaaa    600

atctgacagt ttttctcaca acaaccctgt gagatttagg cctattaaag gaaggcagga    660

agaactaaag gaagtaattg aacgttttaa gaaagatgaa cacttggaga aagccttcaa    720

atgtttgact tcaggcgaat gggcacggca ctattttctc aacaagaata aaatgcagga    780

gaaattattc aaagaacatg tatttattta tttgcgaatg tttgcaactg acagtggatt    840

tgaaatattg ccatgtaata gatactcatc agaacaaaat ggagccaaaa tagttgcaac    900

aaaagagtgg aaacgaaatg acaaaataga attactggtg ggttgtattg ccgaactttc    960

agaaattgag gagaacatgc tacttagaca tggagaaaac gacttcagtg tcatgtactc   1020

cacaaggaaa aactgtgctc aactctggct gggtcctgct gcgtttataa accatgattg   1080

cagacctaat tgtaagtttg tgtcaactgg tcgagataca gcatgtgtga aggctctaag   1140

agacattgaa cctggagaag aaatttcttg ttattatgga gatgggttct ttggagaaaa   1200

taatgagttc tgcgagtgtt acacttgcga aagacggggc actggtgctt ttaaatccag   1260

agtgggactg cctgcgcctg ctcctgttat caatagcaaa tatggactca gagaaacaga   1320

taaacgttta aataggctta aaaagttagg tgacagcagc aaaaattcag acagtcaatc   1380

tgtcagctct aacactgatg cagataccac tcaggaaaaa aacaatgcaa cttctaaccg   1440

aaaatcttca gttggcgtaa aaaagaatag caagagcaga acgttaacga ggcaatctat   1500

gtcaagaatt ccagcttctt ccaactctac ctcatctaag ctaactcata taaataattc   1560

cagggtacca aagaaactga agaagcctgc aaagccttta ctttcaaaga taaaattgag   1620

aaatcattgc aagcggctgg agcaaaagaa tgcttcaaga aaactcgaaa tgggaaactt   1680

agtactgaaa gagcctaaag tagttctgta taaaaatttg cccattaaaa aagataagga   1740

gccagaggga ccagcccaag ccgcagttgc cagcgggtgc ttgactagac acgcggcgag   1800

agaacacaga cagaatcctg tgagaggtgc tcattcgcag ggggagagct cgccctgcac   1860

ctacataact cggcggtcag tgaggacaag aacaaatctg aaggaggcct ctgacatcaa   1920

gcttgaacca aatacgttga atggctataa aagcagtgtg acggaacctt gccccgacag   1980

tggtgaacag ctgcagccag ctcctgtgct gcaggaggaa gaactggctc atgagactgc   2040

acaaaaaggg gaggcaaagt gtcataagag tgacacaggc atgtccaaaa agaagtcacg   2100

acaaggaaaa cttgtgaaac agtttgcaaa aatagaggaa tctactccag tgcacgattc   2160

tcctggaaaa gacgacgcgg taccagattt gatgggtccc cattctgacc agggtgagca   2220

cagtggcact gtgggcgtgc ctgtgagcta cacagactgt gctccttcac ccgtcggttg   2280

ttcagttgtg acatcagata gcttcaaaac aaaagacagc tttagaactg caaaaagtaa   2340

aaagaagagg cgaatcacaa ggtatgatgc acagttaatc ctagaaaata actctgggat   2400

tcccaaattg actcttcgta ggcgtcatga tagcagcagc aaaacaaatg accaagagaa   2460

tgatggaatg aactcttcca aaataagcat caagttaagc aaagaccatg acaacgataa   2520

caatctctat gtagcaaagc ttaataatgg atttaactca ggatcaggca gtagttctac   2580

aaaattaaaa atccagctaa aacgagatga ggaaaatagg gggtcttata cagaggggct   2640

tcatgaaaat ggggtgtgct gcagtgatcc tctttctctc ttggagtctc gaatggaggt   2700

ggatgactat agtcagtatg aggaagaaag tacagatgat tcctcctctt ctgagggcga   2760

tgaagaggag gatgactatg atgatgactt tgaagacgat tttattcctc ttcctccagc   2820

taagcgcttg aggttaatag ttggaaaaga ctctatagat attgacattt cttcaaggag   2880

aagagaagat cagtctttaa ggcttaatgc ctaagctctt ggtcttaact tgacctggga   2940

taactacttt aaagaaataa aaaattccag tcaattattc ctcaactgaa agtttagtgg   3000

cagcacttct attgtccctt cacttatcag catactattg tagaaagtgt acagcatact   3060

gactcaattc ttaagtctga tttgtgcaaa tttttatcgt actttttaaa tagccttctt   3120

acgtgcaatt ctgagttaga ggtaaagccc tgttgtaaaa taaaggctca agcaaaattg   3180

tacagtgata gcaactttcc acacaggacg ttgaaaacag taatgtggct acacagtttt   3240

tttaactgta agagcatcag ctggctcttt aatatatgac taaacaataa tttaaaacaa   3300

atcatagtag cagcatatta agggtttcta gtatgctaat atcaccagca atgatctttg   3360

gctttttgat ttatttgcta gatgtttccc ccttggagtt ttgtcagttt cacactgttt   3420

gctggcccag gtgtactgtt tgtggccttt gttaatatcg caaaccattg gttgggagtc   3480

agattggttt cttaaaaaaa aaaaaaaaat gacatacgtg acagctcact tttcagttca   3540

ttatatgtac gagggtagca gtgtgtggga tgaggttcga tacagcgtat ttattgcttg   3600

tcatgtaaat taaaaacctt gtatttaact cttttcaatc cttttagata aaattgttct   3660

ttgcaagaat gattggtgct tattttttca aaaatttgct gtgaacaacg tgatgacaac   3720

aagcaacatt tatctaatga actacagcta tcttaatttg gttcttcaag ttttctgttg   3780

cacttgtaaa atgctacaag gaatattaaa aaaatctatt cactttaact tataatagtt   3840

tatgaaataa aaacatgagt cacagctttt gttctgtggt aacctataaa aaaagtttgt   3900

ctttgagatt caatgtaaag aactgaaaac aatgtatatg ttgtaaatat ttgtgtgttg   3960

tgagaaattt ttgtcataag aaattaaaag aacttaccag gaaggttttt aagtttagaa   4020

atattcatgc caataaaata ggaaattata aatatatagt tttaagcact gcatcagtgg   4080

gagttcttgg cttatgttag tttatgttag tttattatga aaacatcaaa gatttttttg   4140

actatattat cagttaaaca aaaaggagtc agatttaatt tgttttttga agcactttga   4200

gaaattaatt ttaattaact taatgagcaa atttttatta ctactttatg ttcaatacca   4260

ggttcttttc atttctctgg attattttgc aaatcattgg acagagaatt tgggaatata   4320

aatctgtaac aggtgtttga caccagtagg tctctttatt tctgggaaat gtgtacctgt   4380

actttctgat atacagtgtt cctaagtaaa aatcaattca ggggatttgt atagtgtcta   4440

taggaaagta gcccatgtct tgaaatatga aaaggaatct gaaggtcatg aaaagtccag   4500

tggagaaaat ctcaatgctt actgttacta ctaattgatt cctactagtt tccaggtttg   4560

gg                                                                  4562


<210>  2841
<211>  885
<212>  PRT
<213>  Homosapiens

<400>  2841

Met Lys Trp Leu Gly Glu Ser Lys Asn Met Val Val Asn Gly Arg Arg 
1               5                   10                  15      


Asn Gly Gly Lys Leu Ser Asn Asp His Gln Gln Asn Gln Ser Lys Leu 
            20                  25                  30          


Gln His Thr Gly Lys Asp Thr Leu Lys Ala Gly Lys Asn Ala Val Glu 
        35                  40                  45              


Arg Arg Ser Asn Arg Cys Asn Gly Asn Ser Gly Phe Glu Gly Gln Ser 
    50                  55                  60                  


Arg Tyr Val Pro Ser Ser Gly Met Ser Ala Lys Glu Leu Cys Glu Asn 
65                  70                  75                  80  


Asp Asp Leu Ala Thr Ser Leu Val Leu Asp Pro Tyr Leu Gly Phe Gln 
                85                  90                  95      


Thr His Lys Met Asn Thr Ser Ala Phe Pro Ser Arg Ser Ser Arg His 
            100                 105                 110         


Phe Ser Lys Ser Asp Ser Phe Ser His Asn Asn Pro Val Arg Phe Arg 
        115                 120                 125             


Pro Ile Lys Gly Arg Gln Glu Glu Leu Lys Glu Val Ile Glu Arg Phe 
    130                 135                 140                 


Lys Lys Asp Glu His Leu Glu Lys Ala Phe Lys Cys Leu Thr Ser Gly 
145                 150                 155                 160 


Glu Trp Ala Arg His Tyr Phe Leu Asn Lys Asn Lys Met Gln Glu Lys 
                165                 170                 175     


Leu Phe Lys Glu His Val Phe Ile Tyr Leu Arg Met Phe Ala Thr Asp 
            180                 185                 190         


Ser Gly Phe Glu Ile Leu Pro Cys Asn Arg Tyr Ser Ser Glu Gln Asn 
        195                 200                 205             


Gly Ala Lys Ile Val Ala Thr Lys Glu Trp Lys Arg Asn Asp Lys Ile 
    210                 215                 220                 


Glu Leu Leu Val Gly Cys Ile Ala Glu Leu Ser Glu Ile Glu Glu Asn 
225                 230                 235                 240 


Met Leu Leu Arg His Gly Glu Asn Asp Phe Ser Val Met Tyr Ser Thr 
                245                 250                 255     


Arg Lys Asn Cys Ala Gln Leu Trp Leu Gly Pro Ala Ala Phe Ile Asn 
            260                 265                 270         


His Asp Cys Arg Pro Asn Cys Lys Phe Val Ser Thr Gly Arg Asp Thr 
        275                 280                 285             


Ala Cys Val Lys Ala Leu Arg Asp Ile Glu Pro Gly Glu Glu Ile Ser 
    290                 295                 300                 


Cys Tyr Tyr Gly Asp Gly Phe Phe Gly Glu Asn Asn Glu Phe Cys Glu 
305                 310                 315                 320 


Cys Tyr Thr Cys Glu Arg Arg Gly Thr Gly Ala Phe Lys Ser Arg Val 
                325                 330                 335     


Gly Leu Pro Ala Pro Ala Pro Val Ile Asn Ser Lys Tyr Gly Leu Arg 
            340                 345                 350         


Glu Thr Asp Lys Arg Leu Asn Arg Leu Lys Lys Leu Gly Asp Ser Ser 
        355                 360                 365             


Lys Asn Ser Asp Ser Gln Ser Val Ser Ser Asn Thr Asp Ala Asp Thr 
    370                 375                 380                 


Thr Gln Glu Lys Asn Asn Ala Thr Ser Asn Arg Lys Ser Ser Val Gly 
385                 390                 395                 400 


Val Lys Lys Asn Ser Lys Ser Arg Thr Leu Thr Arg Gln Ser Met Ser 
                405                 410                 415     


Arg Ile Pro Ala Ser Ser Asn Ser Thr Ser Ser Lys Leu Thr His Ile 
            420                 425                 430         


Asn Asn Ser Arg Val Pro Lys Lys Leu Lys Lys Pro Ala Lys Pro Leu 
        435                 440                 445             


Leu Ser Lys Ile Lys Leu Arg Asn His Cys Lys Arg Leu Glu Gln Lys 
    450                 455                 460                 


Asn Ala Ser Arg Lys Leu Glu Met Gly Asn Leu Val Leu Lys Glu Pro 
465                 470                 475                 480 


Lys Val Val Leu Tyr Lys Asn Leu Pro Ile Lys Lys Asp Lys Glu Pro 
                485                 490                 495     


Glu Gly Pro Ala Gln Ala Ala Val Ala Ser Gly Cys Leu Thr Arg His 
            500                 505                 510         


Ala Ala Arg Glu His Arg Gln Asn Pro Val Arg Gly Ala His Ser Gln 
        515                 520                 525             


Gly Glu Ser Ser Pro Cys Thr Tyr Ile Thr Arg Arg Ser Val Arg Thr 
    530                 535                 540                 


Arg Thr Asn Leu Lys Glu Ala Ser Asp Ile Lys Leu Glu Pro Asn Thr 
545                 550                 555                 560 


Leu Asn Gly Tyr Lys Ser Ser Val Thr Glu Pro Cys Pro Asp Ser Gly 
                565                 570                 575     


Glu Gln Leu Gln Pro Ala Pro Val Leu Gln Glu Glu Glu Leu Ala His 
            580                 585                 590         


Glu Thr Ala Gln Lys Gly Glu Ala Lys Cys His Lys Ser Asp Thr Gly 
        595                 600                 605             


Met Ser Lys Lys Lys Ser Arg Gln Gly Lys Leu Val Lys Gln Phe Ala 
    610                 615                 620                 


Lys Ile Glu Glu Ser Thr Pro Val His Asp Ser Pro Gly Lys Asp Asp 
625                 630                 635                 640 


Ala Val Pro Asp Leu Met Gly Pro His Ser Asp Gln Gly Glu His Ser 
                645                 650                 655     


Gly Thr Val Gly Val Pro Val Ser Tyr Thr Asp Cys Ala Pro Ser Pro 
            660                 665                 670         


Val Gly Cys Ser Val Val Thr Ser Asp Ser Phe Lys Thr Lys Asp Ser 
        675                 680                 685             


Phe Arg Thr Ala Lys Ser Lys Lys Lys Arg Arg Ile Thr Arg Tyr Asp 
    690                 695                 700                 


Ala Gln Leu Ile Leu Glu Asn Asn Ser Gly Ile Pro Lys Leu Thr Leu 
705                 710                 715                 720 


Arg Arg Arg His Asp Ser Ser Ser Lys Thr Asn Asp Gln Glu Asn Asp 
                725                 730                 735     


Gly Met Asn Ser Ser Lys Ile Ser Ile Lys Leu Ser Lys Asp His Asp 
            740                 745                 750         


Asn Asp Asn Asn Leu Tyr Val Ala Lys Leu Asn Asn Gly Phe Asn Ser 
        755                 760                 765             


Gly Ser Gly Ser Ser Ser Thr Lys Leu Lys Ile Gln Leu Lys Arg Asp 
    770                 775                 780                 


Glu Glu Asn Arg Gly Ser Tyr Thr Glu Gly Leu His Glu Asn Gly Val 
785                 790                 795                 800 


Cys Cys Ser Asp Pro Leu Ser Leu Leu Glu Ser Arg Met Glu Val Asp 
                805                 810                 815     


Asp Tyr Ser Gln Tyr Glu Glu Glu Ser Thr Asp Asp Ser Ser Ser Ser 
            820                 825                 830         


Glu Gly Asp Glu Glu Glu Asp Asp Tyr Asp Asp Asp Phe Glu Asp Asp 
        835                 840                 845             


Phe Ile Pro Leu Pro Pro Ala Lys Arg Leu Arg Leu Ile Val Gly Lys 
    850                 855                 860                 


Asp Ser Ile Asp Ile Asp Ile Ser Ser Arg Arg Arg Glu Asp Gln Ser 
865                 870                 875                 880 


Leu Arg Leu Asn Ala 
                885 


<210>  2842
<211>  2050
<212>  DNA
<213>  Homosapiens

<400>  2842
gcctgggttg cgctgccggc cacgtccccg cgccgggcct caggctcctt cctactgtcc     60

gagggccacc aggccgccgg gggcctgctg cgcccggatg cgtctgttac tagagtggag    120

agtctacctt cgtctcacat gtgccacaaa ggatggcatg gcccgggagt gccccaccac    180

gtggctttca ccccctgcaa agccagactt cgcccagcga cacagtgtca agcccacagc    240

tctccaagga ggaagatggt ccaggctggg agcatcccct tagcagcagc ctctgatccc    300

ttggccaagc aggagggaac cattagcagc ctgaggagct ggctggctgg gagcctcggg    360

gaccgcccag ccttgctccc agctcaccca caagatgtgg acagctcttg tgctcatttg    420

gattttctcc ttgtccttat ctgaaagcca tgcggcatcc aacgatccac gcaactttgt    480

ccctaacaaa atgtggaagg gattagtcaa gaggaatgca tctgtggaaa cagttgataa    540

taaaacgtct gaggatgtaa ccatggcagc agcttctcct gtcacattga ccaaagggac    600

ttcggcagcc cacctcaact ctatggaagt cacaacagag gacacaagca ggacagatgt    660

gagtgaacca gcaacttcag gaggtgcagc tgatggtgtg acctccattg ctcccacggc    720

tgtggcctcc agtacgactg cggcctccat tacgactgcg gcctccagta tgactgtggc    780

ctccagtgct cccacgactg cagcctccag tacaactgtg gcctccattg ctcccacgac    840

tgcagcctcc agtatgactg cggcctccag cactcccatg acacttgcac tccccgcgcc    900

cacgtccact tccacagggc ggaccccgtc cactaccgcc actgggcatc catctctcag    960

cacagccctc gcacaagtgc caaagagcag cgcgttgcca agaacagcaa ccctggccac   1020

attggccaca cgtgctcaga ctgtagcgac cacagcaaac acaagcagcc ccatgagcac   1080

tcgtccaagt ccttccaagc acatgcccag tgacaccgcg gcaagccctg taccccctat   1140

gcgtccccaa gcacaaggtc ccattagcca ggtgtcagtg gaccagcctg tggttaacac   1200

aacaaataaa tccacaccca tgccctcaaa cacaacccca gagcccgccc ccacccccac   1260

agtggtgacc accaccaagg cacaagccag ggagccaact gccagcccag tgccagtacc   1320

tcacaccagc ccaatccctg agatggaggc catgtccccc acgacacagc caagccccat   1380

gccatatacc cagagggccg ctgggccagg cacatcccag gcaccggagc aggtagagac   1440

tgaagccaca ccaggtactg attccactgg gccaacaccc aggagctcag ggggcactaa   1500

gatgccagcc acggactcgt gccagcccag cacccaaggc cagtacatgg tggtcaccac   1560

tgagcccctc acccaggccg tggtagacaa aactctcctt ctggtggtgc tgttactcgg   1620

ggtgaccctt ttcatcacag tcttggtttt gtttgccctg caggcctatg agagctacaa   1680

gaagaaggac tacacccagg tggactactt aatcaacggg atgtatgcgg actcagaaat   1740

gtgagggggg cgggggcctg gcgggaggcc tggccccttc ctcgtccttt ccttttgcct   1800

ttgagaccaa accaagtgct tccaaattct tttggtgcaa ttgaggagat atgccagatg   1860

cttaaacaca tttaattgct gtcagattaa ttccatgatc actaaagagt tgctgctttt   1920

ttcatattta tttttgtaaa tgattctgtg cccaggagca gctgggggtt ccacctcagg   1980

gtggggcggg caggaccccg tctccccagg tgtcggagcc tgacctgaat taaagtactg   2040

actgctcgcc                                                          2050


<210>  2843
<211>  449
<212>  PRT
<213>  Homosapiens

<400>  2843

Met Trp Thr Ala Leu Val Leu Ile Trp Ile Phe Ser Leu Ser Leu Ser 
1               5                   10                  15      


Glu Ser His Ala Ala Ser Asn Asp Pro Arg Asn Phe Val Pro Asn Lys 
            20                  25                  30          


Met Trp Lys Gly Leu Val Lys Arg Asn Ala Ser Val Glu Thr Val Asp 
        35                  40                  45              


Asn Lys Thr Ser Glu Asp Val Thr Met Ala Ala Ala Ser Pro Val Thr 
    50                  55                  60                  


Leu Thr Lys Gly Thr Ser Ala Ala His Leu Asn Ser Met Glu Val Thr 
65                  70                  75                  80  


Thr Glu Asp Thr Ser Arg Thr Asp Val Ser Glu Pro Ala Thr Ser Gly 
                85                  90                  95      


Gly Ala Ala Asp Gly Val Thr Ser Ile Ala Pro Thr Ala Val Ala Ser 
            100                 105                 110         


Ser Thr Thr Ala Ala Ser Ile Thr Thr Ala Ala Ser Ser Met Thr Val 
        115                 120                 125             


Ala Ser Ser Ala Pro Thr Thr Ala Ala Ser Ser Thr Thr Val Ala Ser 
    130                 135                 140                 


Ile Ala Pro Thr Thr Ala Ala Ser Ser Met Thr Ala Ala Ser Ser Thr 
145                 150                 155                 160 


Pro Met Thr Leu Ala Leu Pro Ala Pro Thr Ser Thr Ser Thr Gly Arg 
                165                 170                 175     


Thr Pro Ser Thr Thr Ala Thr Gly His Pro Ser Leu Ser Thr Ala Leu 
            180                 185                 190         


Ala Gln Val Pro Lys Ser Ser Ala Leu Pro Arg Thr Ala Thr Leu Ala 
        195                 200                 205             


Thr Leu Ala Thr Arg Ala Gln Thr Val Ala Thr Thr Ala Asn Thr Ser 
    210                 215                 220                 


Ser Pro Met Ser Thr Arg Pro Ser Pro Ser Lys His Met Pro Ser Asp 
225                 230                 235                 240 


Thr Ala Ala Ser Pro Val Pro Pro Met Arg Pro Gln Ala Gln Gly Pro 
                245                 250                 255     


Ile Ser Gln Val Ser Val Asp Gln Pro Val Val Asn Thr Thr Asn Lys 
            260                 265                 270         


Ser Thr Pro Met Pro Ser Asn Thr Thr Pro Glu Pro Ala Pro Thr Pro 
        275                 280                 285             


Thr Val Val Thr Thr Thr Lys Ala Gln Ala Arg Glu Pro Thr Ala Ser 
    290                 295                 300                 


Pro Val Pro Val Pro His Thr Ser Pro Ile Pro Glu Met Glu Ala Met 
305                 310                 315                 320 


Ser Pro Thr Thr Gln Pro Ser Pro Met Pro Tyr Thr Gln Arg Ala Ala 
                325                 330                 335     


Gly Pro Gly Thr Ser Gln Ala Pro Glu Gln Val Glu Thr Glu Ala Thr 
            340                 345                 350         


Pro Gly Thr Asp Ser Thr Gly Pro Thr Pro Arg Ser Ser Gly Gly Thr 
        355                 360                 365             


Lys Met Pro Ala Thr Asp Ser Cys Gln Pro Ser Thr Gln Gly Gln Tyr 
    370                 375                 380                 


Met Val Val Thr Thr Glu Pro Leu Thr Gln Ala Val Val Asp Lys Thr 
385                 390                 395                 400 


Leu Leu Leu Val Val Leu Leu Leu Gly Val Thr Leu Phe Ile Thr Val 
                405                 410                 415     


Leu Val Leu Phe Ala Leu Gln Ala Tyr Glu Ser Tyr Lys Lys Lys Asp 
            420                 425                 430         


Tyr Thr Gln Val Asp Tyr Leu Ile Asn Gly Met Tyr Ala Asp Ser Glu 
        435                 440                 445             


Met 
    


<210>  2844
<211>  855
<212>  DNA
<213>  Homosapiens

<400>  2844
cctttccttt cagcggagcg cggcggcaag atggcagtgc aaatatccaa gaagaggaag     60

tttgtcgctg atggcatctt caaagctgaa ctgaatgagt ttcttactcg ggagctggct    120

gaagatggct actctggagt tgaggtgcga gttacaccaa ccaggacaga aatcattatc    180

ttagccacca gaacacagaa tgttcttggt gagaagggcc ggcggattcg ggaactgact    240

gctgtagttc agaagaggtt tggctttcca gagggcagtg tagagcttta tgctgaaaag    300

gtggccacta gaggtctgtg tgccattgcc caggcagagt ctctgcgtta caaactccta    360

ggagggcttg ctgtgcggag ggcctgctat ggtgtgctgc ggttcatcat ggagagtggg    420

gccaaaggct gcgaggttgt ggtgtctggg aaactccgag gacagagggc taaatccatg    480

aagtttgtgg atggcctgat gatccacagc ggagaccctg ttaactacta cgttgacact    540

gctgtgcgcc acgtgttgct cagacagggt gtgctgggca tcaaggtgaa gatcatgctg    600

ccctgggacc caactggtaa gattggccct aagaagcccc tgcctgacca cgtgagcatt    660

gtggaaccca aagatgagat actgcccacc acccccatct cagaacagaa gggtgggaag    720

ccagagccgc ctgccatgcc ccagccagtc cccacagcat aacagggtct ccttggcagc    780

tgtattctgg agtctggatg ttgctctcta aagaccttta ataaaatttt gtacaaagac    840

aaaaaaaaaa aaaaa                                                     855


<210>  2845
<211>  243
<212>  PRT
<213>  Homosapiens

<400>  2845

Met Ala Val Gln Ile Ser Lys Lys Arg Lys Phe Val Ala Asp Gly Ile 
1               5                   10                  15      


Phe Lys Ala Glu Leu Asn Glu Phe Leu Thr Arg Glu Leu Ala Glu Asp 
            20                  25                  30          


Gly Tyr Ser Gly Val Glu Val Arg Val Thr Pro Thr Arg Thr Glu Ile 
        35                  40                  45              


Ile Ile Leu Ala Thr Arg Thr Gln Asn Val Leu Gly Glu Lys Gly Arg 
    50                  55                  60                  


Arg Ile Arg Glu Leu Thr Ala Val Val Gln Lys Arg Phe Gly Phe Pro 
65                  70                  75                  80  


Glu Gly Ser Val Glu Leu Tyr Ala Glu Lys Val Ala Thr Arg Gly Leu 
                85                  90                  95      


Cys Ala Ile Ala Gln Ala Glu Ser Leu Arg Tyr Lys Leu Leu Gly Gly 
            100                 105                 110         


Leu Ala Val Arg Arg Ala Cys Tyr Gly Val Leu Arg Phe Ile Met Glu 
        115                 120                 125             


Ser Gly Ala Lys Gly Cys Glu Val Val Val Ser Gly Lys Leu Arg Gly 
    130                 135                 140                 


Gln Arg Ala Lys Ser Met Lys Phe Val Asp Gly Leu Met Ile His Ser 
145                 150                 155                 160 


Gly Asp Pro Val Asn Tyr Tyr Val Asp Thr Ala Val Arg His Val Leu 
                165                 170                 175     


Leu Arg Gln Gly Val Leu Gly Ile Lys Val Lys Ile Met Leu Pro Trp 
            180                 185                 190         


Asp Pro Thr Gly Lys Ile Gly Pro Lys Lys Pro Leu Pro Asp His Val 
        195                 200                 205             


Ser Ile Val Glu Pro Lys Asp Glu Ile Leu Pro Thr Thr Pro Ile Ser 
    210                 215                 220                 


Glu Gln Lys Gly Gly Lys Pro Glu Pro Pro Ala Met Pro Gln Pro Val 
225                 230                 235                 240 


Pro Thr Ala 
            


<210>  2846
<211>  148
<212>  DNA
<213>  Homosapiens

<400>  2846
cttcgatgaa gagatgatga cgagtctgac ttggggatgt tctctttgcc caggtggcct     60

actctgtgct gcgttctgtg gcacagttta aagagccctg gttgaagtaa tttcctaaag    120

atgacttaga ggcatttgtc tgagaagg                                       148


<210>  2847
<211>  146
<212>  DNA
<213>  Homosapiens

<400>  2847
cttcagtgat gacacgatga cgagtcagaa aggtcacgtc ctgctcttgg tccttgtcag     60

tgccatgttc tgtggtgctg tgcacgagtt cctttggcag aagtgtccta tttattgatc    120

gatttagagg catttgtctg agaagg                                         146


<210>  2848
<211>  1511
<212>  DNA
<213>  Homosapiens

<400>  2848
ggccgcctgc gcgccgccaa cagcctagcg ctgcgccgcg tggccgccgc cttctcgctg     60

gccccgctgg ccgagcgctg cggccgcgtc ctgcgtcagg ccttcgccga ggtggcgcgc    120

cacgccgact tcctggagct ggcgcctgac gaggtggtgg cgctgctggc ggaccccgcg    180

ctgggcgtgg cgcgcgagga ggccgtgttt gaagcggcca tgcgctgggt gcgccacgac    240

gcgccggccc gccgcggcca gctgcgacgc ctgctggagc acgtgcgcct gccgctactg    300

gcgcccgctt acttcctgga gaaggtggag gcggacgagc tgctgcaggc ctgcggcgag    360

tgccgcccgc tgctgctcga ggctcgcgcc tgcttcatcc tgggccgcga ggccggtgcg    420

ctgcggaccc ggccgcggag attcatggac ctagctgaag tgatcgtggt catcggcggt    480

tgcgaccgca aaggtctcct gaagctgccc ttcgccgatg cctaccatcc agagagccag    540

cggtggaccc cactgcccag cctgcccggc tacactcgct cagaattcgc cgcctgtgct    600

ctccgcaatg acgtctacgt ctccggaggc cacatcaaca gtcatgatgt gtggatgttt    660

agctcccatc tgcacacctg gatcaaggta gcctctctgc acaagggcag gtggaggcac    720

aagatggcag ttgtgcaggg gcagctgttc gcggtgggtg gcttcgacgg cctgaggcgc    780

ctgcacagcg tggagcgcta cgaccccttc tccaacacct gggcggccgc cgcgcccctc    840

ccggaggccg tgagctcggc ggcggtggcg tcctgcgcgg gcaagctctt cgtgattggg    900

ggcgccaggc agggcggcgt caacacggac aaggtgcagt gctttgaccc caaggaggac    960

cggtggagcc tgcggtcacc agcacccttc tcacagcggt gtctcgaggc tgtctccctt   1020

gaggacacca tctatgtcat ggggggtctc atgagcaaaa tcttcaccta tgatccaggc   1080

acagatgtgt ggggggaggc agctgtcctc cccagccctg tggaaagctg tggagtcact   1140

gtgtgtgacg ggaaggtcca catccttggc gggcgggatg atcgcggaga aagcaccgat   1200

aaggtcttca cctttgaccc cagcagtggg caggtggagg tccagccatc cctgcagcgc   1260

tgcaccagct cccacggctg tgtcaccatc atccagagct tgggcaggtg attcagattt   1320

ggacagcctg agccaggagg cggagaggca ggcggagctc agatgcacac tctgctccct   1380

catggcacct ccacgcaaac agcccttaac ttaatggtcc cttttcttgt ataaataaaa   1440

tcttgttggg tctgtgttcc agctgcagtc tgccctgcct ggagatggaa tgtctaaaaa   1500

aaaaaaaaaa a                                                        1511


<210>  2849
<211>  363
<212>  PRT
<213>  Homosapiens

<400>  2849

Met Arg Trp Val Arg His Asp Ala Pro Ala Arg Arg Gly Gln Leu Arg 
1               5                   10                  15      


Arg Leu Leu Glu His Val Arg Leu Pro Leu Leu Ala Pro Ala Tyr Phe 
            20                  25                  30          


Leu Glu Lys Val Glu Ala Asp Glu Leu Leu Gln Ala Cys Gly Glu Cys 
        35                  40                  45              


Arg Pro Leu Leu Leu Glu Ala Arg Ala Cys Phe Ile Leu Gly Arg Glu 
    50                  55                  60                  


Ala Gly Ala Leu Arg Thr Arg Pro Arg Arg Phe Met Asp Leu Ala Glu 
65                  70                  75                  80  


Val Ile Val Val Ile Gly Gly Cys Asp Arg Lys Gly Leu Leu Lys Leu 
                85                  90                  95      


Pro Phe Ala Asp Ala Tyr His Pro Glu Ser Gln Arg Trp Thr Pro Leu 
            100                 105                 110         


Pro Ser Leu Pro Gly Tyr Thr Arg Ser Glu Phe Ala Ala Cys Ala Leu 
        115                 120                 125             


Arg Asn Asp Val Tyr Val Ser Gly Gly His Ile Asn Ser His Asp Val 
    130                 135                 140                 


Trp Met Phe Ser Ser His Leu His Thr Trp Ile Lys Val Ala Ser Leu 
145                 150                 155                 160 


His Lys Gly Arg Trp Arg His Lys Met Ala Val Val Gln Gly Gln Leu 
                165                 170                 175     


Phe Ala Val Gly Gly Phe Asp Gly Leu Arg Arg Leu His Ser Val Glu 
            180                 185                 190         


Arg Tyr Asp Pro Phe Ser Asn Thr Trp Ala Ala Ala Ala Pro Leu Pro 
        195                 200                 205             


Glu Ala Val Ser Ser Ala Ala Val Ala Ser Cys Ala Gly Lys Leu Phe 
    210                 215                 220                 


Val Ile Gly Gly Ala Arg Gln Gly Gly Val Asn Thr Asp Lys Val Gln 
225                 230                 235                 240 


Cys Phe Asp Pro Lys Glu Asp Arg Trp Ser Leu Arg Ser Pro Ala Pro 
                245                 250                 255     


Phe Ser Gln Arg Cys Leu Glu Ala Val Ser Leu Glu Asp Thr Ile Tyr 
            260                 265                 270         


Val Met Gly Gly Leu Met Ser Lys Ile Phe Thr Tyr Asp Pro Gly Thr 
        275                 280                 285             


Asp Val Trp Gly Glu Ala Ala Val Leu Pro Ser Pro Val Glu Ser Cys 
    290                 295                 300                 


Gly Val Thr Val Cys Asp Gly Lys Val His Ile Leu Gly Gly Arg Asp 
305                 310                 315                 320 


Asp Arg Gly Glu Ser Thr Asp Lys Val Phe Thr Phe Asp Pro Ser Ser 
                325                 330                 335     


Gly Gln Val Glu Val Gln Pro Ser Leu Gln Arg Cys Thr Ser Ser His 
            340                 345                 350         


Gly Cys Val Thr Ile Ile Gln Ser Leu Gly Arg 
        355                 360             


<210>  2850
<211>  3503
<212>  DNA
<213>  Homosapiens

<400>  2850
ggccgggagc tcgggagtcg gccgccgcgc cgaggttcgc cccgttttgc agagagagcc     60

gagtcgggac ctggaaagac gtccccgcgg ggctccggcc gccgcgcctc cccgccggcg    120

cctgccctgc cctgcccgtc ccagccccgc ggttcggggc gtgcggccgg gacgcgcgga    180

gccccggccc tgacccgctg cgccgggacg ggacgctcct aacgccgccg taccggtccg    240

tggttgcagg gtcgctccgc gcctttccgt cagtgagggt cggaacccca gctccagggc    300

tagcgcagtg tggccccagg ccctcgcctc cggtgcacgg gaccccggac ccccccaagc    360

ctctggcttc acgagacccc aaccttcagt tggaacagct tggaacagcg cgagcgcccg    420

ggaagccctg gccgggtcgt gcgctccgtg aggggtccta ggcgggcagg acagtcggac    480

cgaaccgccg ggctggtgcc gcgagcccag gctgtcacct tcgtcccgcc tcaggcgagg    540

ggttcagcgc ctgccccgaa gataacacag gggtcccctt ctgtcccggc ggcccgcgag    600

agccaaggct gcagctctcc cagtgaagtg atatcactgc ctctgtggac aagacacctc    660

caggagccca gctcacagcc accggtacct tcttccagga caagctgggg gcctccatgg    720

gcgcctgagg gccaggcgcc agggccgtgg gcacgagtat ggtgagacac cagcccctgc    780

agtactacga gccacagctg tgcctctcct gcctcacggg catctacggc tgccgttgga    840

agcgctacca gcgctcccat gatgatacca caccgtggga gcgcctctgg ttcctgctcc    900

tcaccttcac ctttggcctc acgctcacct ggctttactt ctggtgggaa gtccacaatg    960

actatgatga attcaactgg tacctctaca accgcatggg ctactggagc gactggcccg   1020

tacccatcct tgtgaccaca gctgctgcct tcgcatacat cgctggcctc ctggtcctgg   1080

cactatgtca cattgccgtg gggcagcaga tgaacctgca ctggctgcac aagatcgggc   1140

tggtggtcat cctggcttcc acggtggtgg ccatgtcggc cgtggcccag ctgtgggagg   1200

acgagtggga ggtgctgctg atctccctgc agggcacagc gccattcctg catgtggggg   1260

ctgtggcagc agtcaccatg ctctcctgga tcgtggcagg acagttcgcc cgtgcagagc   1320

ggacctcctc ccaggtgacc attctctgta ccttcttcac cgtggtgttt gccctctacc   1380

tggcccctct caccatctcc tctccctgca tcatggagaa gaaagacctc ggccccaagc   1440

ctgctctcat tggccaccgc ggggccccca tgctggctcc agagcacacg ctcatgtcct   1500

tccggaaggc cctcgagcag aagctgtacg ggctccaggc tgacattacc atcagcctgg   1560

acggcgtgcc cttcctcatg catgacacca ccctgcggcg caccaccaac gtggaggagg   1620

agttcccgga gctggcccgc aggcctgcct ccatgcttaa ctggaccacc ctgcagagac   1680

tcaacgctgg ccagtggttc ctgaagactg accccttctg gacagccagc tccctgtcac   1740

cctccgacca cagagaggcc cagaaccagt ccatctgcag cctggcagag ctcctggagc   1800

tggccaaggg caatgccaca ctgctgctca acctgcgtga cccgccccgg gagcacccct   1860

accgcagcag ttttatcaac gtgactctgg aggccgtgct gcactccggc ttcccccagc   1920

accaggtcat gtggctgcct agcaggcaga ggcccctggt gcggaaggtg gctcccggct   1980

tccaacagac atcaggctcc aaggaggcag tcgccagcct gcggagaggc cacatccagc   2040

ggctgaacct gcgctacact caggtgtccc gccaggagct cagggactac gcgtcctgga   2100

acctgagtgt gaacctctac acagtcaacg caccgtggct cttctccctg ctgtggtgtg   2160

cgggggtccc atccgtcacc tctgacaact cccacaccct gtcccaggtg ccttcccccc   2220

tctggatcat gcccccggac gagtactgtc tcatgtgggt cactgccgac ctggtctcct   2280

tcaccctcat cgtgggcatc ttcgtgctcc agaagtggcg cctgggtggc atacggagct   2340

acaaccctga gcagatcatg ctgagtgctg cggtgcgccg gaccagccgg gacgtcagca   2400

tcatgaagga gaagcttatt ttctcagaga tcagcgatgg tgtagaggtc tccgatgtgc   2460

tctccgtatg ttcagacaac agttatgaca catatgccaa cagcaccgcc acccctgtgg   2520

gcccccgagg gggtggcagc cacaccaaga ccctcataga gcggagtggg cgttagctga   2580

agacatgtct gtcccacctg tacctgacac agaagctggg gagcctagga gagctggtgg   2640

aagtgtgtct gaactcggag tgctctggga gcgggctcca cagcctcctt gtgggctcca   2700

gccccttgtc agccgcagcc tctcttgagg gggactccct gtctcctgag gcccagctgg   2760

gccaggactc catcctttca gatgcccctg caggcctggg gctccttctg ggaagtatgg   2820

ggcctagggc ttggtccccc tcttctgagg ccctctcctg tatcccgacc tggaagcttt   2880

gatgggtcat gggccatgcc ataccccctg tggcaatgga gtgtgtggat gctcacctgt   2940

gccatctgtc ctcctgtctg tgccaggagg cacctgagtt ctctgctgtt atcctgcccc   3000

aagggcctgg gccgagcctc tacctgaagc aactctgctc ttcctgtcag tctcaaagca   3060

caaggaggtt cagcccagga ggaagccagc tgcaatgtgg agacacgtcc tcctccccaa   3120

cccacctcat gccaccgcca accccctgcc ccaggagcgg gcctgagcca cgtcccctag   3180

gagcagctgg agatggccaa aagagtgagc tcaggactac tggatcccat gcccaggtgt   3240

ccagcagacc tcaaggcaga agggtcacct aacccaggag tccacagact gatgtgacct   3300

caggttccca catcagtggc cacagggcag ggcccacctg gtagaagtgt tctggatatg   3360

gccagggtgg gtgtgtggct aagtgggcct gaacagaggg aacctagggc ccttggcaat   3420

gtgatttaaa gctgccatct tgcggaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3480

aaaaaaaaaa aaaaaaaaaa aaa                                           3503


<210>  2851
<211>  605
<212>  PRT
<213>  Homosapiens

<400>  2851

Met Val Arg His Gln Pro Leu Gln Tyr Tyr Glu Pro Gln Leu Cys Leu 
1               5                   10                  15      


Ser Cys Leu Thr Gly Ile Tyr Gly Cys Arg Trp Lys Arg Tyr Gln Arg 
            20                  25                  30          


Ser His Asp Asp Thr Thr Pro Trp Glu Arg Leu Trp Phe Leu Leu Leu 
        35                  40                  45              


Thr Phe Thr Phe Gly Leu Thr Leu Thr Trp Leu Tyr Phe Trp Trp Glu 
    50                  55                  60                  


Val His Asn Asp Tyr Asp Glu Phe Asn Trp Tyr Leu Tyr Asn Arg Met 
65                  70                  75                  80  


Gly Tyr Trp Ser Asp Trp Pro Val Pro Ile Leu Val Thr Thr Ala Ala 
                85                  90                  95      


Ala Phe Ala Tyr Ile Ala Gly Leu Leu Val Leu Ala Leu Cys His Ile 
            100                 105                 110         


Ala Val Gly Gln Gln Met Asn Leu His Trp Leu His Lys Ile Gly Leu 
        115                 120                 125             


Val Val Ile Leu Ala Ser Thr Val Val Ala Met Ser Ala Val Ala Gln 
    130                 135                 140                 


Leu Trp Glu Asp Glu Trp Glu Val Leu Leu Ile Ser Leu Gln Gly Thr 
145                 150                 155                 160 


Ala Pro Phe Leu His Val Gly Ala Val Ala Ala Val Thr Met Leu Ser 
                165                 170                 175     


Trp Ile Val Ala Gly Gln Phe Ala Arg Ala Glu Arg Thr Ser Ser Gln 
            180                 185                 190         


Val Thr Ile Leu Cys Thr Phe Phe Thr Val Val Phe Ala Leu Tyr Leu 
        195                 200                 205             


Ala Pro Leu Thr Ile Ser Ser Pro Cys Ile Met Glu Lys Lys Asp Leu 
    210                 215                 220                 


Gly Pro Lys Pro Ala Leu Ile Gly His Arg Gly Ala Pro Met Leu Ala 
225                 230                 235                 240 


Pro Glu His Thr Leu Met Ser Phe Arg Lys Ala Leu Glu Gln Lys Leu 
                245                 250                 255     


Tyr Gly Leu Gln Ala Asp Ile Thr Ile Ser Leu Asp Gly Val Pro Phe 
            260                 265                 270         


Leu Met His Asp Thr Thr Leu Arg Arg Thr Thr Asn Val Glu Glu Glu 
        275                 280                 285             


Phe Pro Glu Leu Ala Arg Arg Pro Ala Ser Met Leu Asn Trp Thr Thr 
    290                 295                 300                 


Leu Gln Arg Leu Asn Ala Gly Gln Trp Phe Leu Lys Thr Asp Pro Phe 
305                 310                 315                 320 


Trp Thr Ala Ser Ser Leu Ser Pro Ser Asp His Arg Glu Ala Gln Asn 
                325                 330                 335     


Gln Ser Ile Cys Ser Leu Ala Glu Leu Leu Glu Leu Ala Lys Gly Asn 
            340                 345                 350         


Ala Thr Leu Leu Leu Asn Leu Arg Asp Pro Pro Arg Glu His Pro Tyr 
        355                 360                 365             


Arg Ser Ser Phe Ile Asn Val Thr Leu Glu Ala Val Leu His Ser Gly 
    370                 375                 380                 


Phe Pro Gln His Gln Val Met Trp Leu Pro Ser Arg Gln Arg Pro Leu 
385                 390                 395                 400 


Val Arg Lys Val Ala Pro Gly Phe Gln Gln Thr Ser Gly Ser Lys Glu 
                405                 410                 415     


Ala Val Ala Ser Leu Arg Arg Gly His Ile Gln Arg Leu Asn Leu Arg 
            420                 425                 430         


Tyr Thr Gln Val Ser Arg Gln Glu Leu Arg Asp Tyr Ala Ser Trp Asn 
        435                 440                 445             


Leu Ser Val Asn Leu Tyr Thr Val Asn Ala Pro Trp Leu Phe Ser Leu 
    450                 455                 460                 


Leu Trp Cys Ala Gly Val Pro Ser Val Thr Ser Asp Asn Ser His Thr 
465                 470                 475                 480 


Leu Ser Gln Val Pro Ser Pro Leu Trp Ile Met Pro Pro Asp Glu Tyr 
                485                 490                 495     


Cys Leu Met Trp Val Thr Ala Asp Leu Val Ser Phe Thr Leu Ile Val 
            500                 505                 510         


Gly Ile Phe Val Leu Gln Lys Trp Arg Leu Gly Gly Ile Arg Ser Tyr 
        515                 520                 525             


Asn Pro Glu Gln Ile Met Leu Ser Ala Ala Val Arg Arg Thr Ser Arg 
    530                 535                 540                 


Asp Val Ser Ile Met Lys Glu Lys Leu Ile Phe Ser Glu Ile Ser Asp 
545                 550                 555                 560 


Gly Val Glu Val Ser Asp Val Leu Ser Val Cys Ser Asp Asn Ser Tyr 
                565                 570                 575     


Asp Thr Tyr Ala Asn Ser Thr Ala Thr Pro Val Gly Pro Arg Gly Gly 
            580                 585                 590         


Gly Ser His Thr Lys Thr Leu Ile Glu Arg Ser Gly Arg 
        595                 600                 605 


<210>  2852
<211>  2242
<212>  DNA
<213>  Homosapiens

<400>  2852
caccggatct gcttccaggg cttggtttcg ctttgcctgg ctcttggcta ggcctggcgc     60

cccgcgcgga gccgagcagg tggcagccga ggagtggcgg gggctggaac atttaaccct    120

ttgggagcac ctgccctctc ccagagggcg cgtccccgga tcaggcccgg tgccccgcag    180

cgcgcgtggg tcctggctgg ctggaaggag gccctgacct tgctttctct cccgtgccag    240

gtctgccaag gaccatgggt gccgcgctgg ggacaggcac gcggctggct ccctggccgg    300

gccgggcctg cggcgccctc ccgcgctgga cacccaccgc gcccgcccaa ggctgccact    360

ccaagcctgg cccggcgcgc cctgtgcccc tgaagaagcg cggatacgat gtcaccagga    420

accctcatct caacaagggg atggccttta cccttgaaga aaggctgcag cttggaatcc    480

acggcctaat cccgccctgc tttctgagcc aggacgtcca gctcctccga atcatgagat    540

attacgagcg gcagcagagt gacctggaca agtacatcat tctcatgaca ctccaagacc    600

ggaacgagaa gctcttctac cgagtgctga cttcggacgt ggagaagttc atgccaatcg    660

tgtacacgcc taccgtgggg ctggcctgtc agcactatgg cctgactttc cgcaggcccc    720

gtggactgtt catcaccatt catgacaaag gtcatcttgc aacaatgctg aattcttggc    780

cagaagacaa tattaaggcc gtggtggtga ctgatgggga gcgcatcctg ggcctgggag    840

acctgggctg ctacggcatg ggcatccctg tgggcaagct ggccctgtac acggcatgcg    900

gaggggtgaa cccgcagcag tgcctccctg tgctgctgga cgtcggcacc aacaatgagg    960

agctgctcag agaccctctg tacatcggcc tgaaacacca gcgcgtgcac gggaaggcat   1020

acgatgactt gctggatgag ttcatgcagg ctgtgacaga caagtttgga ataaattgcc   1080

tcatccaatt tgaagacttc gccaatgcca atgccttccg cctgctcaac aaataccgta   1140

acaagtactg catgttcaat gatgacatcc aaggcacagc ctccgttgct gtggcaggga   1200

tcttggctgc tctgcgaatc accaagaaca agctttccaa tcacgtgttt gttttccaag   1260

gtgcaggcga ggcagctatg ggcattgccc acctccttgt catggcccta gagaaagaag   1320

gtgtaccgaa ggcagaggcc acaagaaaga tctggatggt ggactctaaa gggctcattg   1380

tcaaggggag gagccacctg aaccatgaaa aggagatgtt tgcccaagac catcctgaag   1440

tcaactccct ggaggaggtg gtgaggctgg tgaagcccac agccatcata ggtgttgctg   1500

ccatcgcagg agccttcacg gagcagattc tgagggacat ggcctccttc cacgagcgcc   1560

ctatcatctt tgccctgagc aaccccacca gcaaggccga gtgcacggct gagaagtgct   1620

accgggtcac cgagggccga gggatttttg ccagtggaag tccttttaag agtgtgactc   1680

tggaagatgg caagaccttc attcctgggc agggaaacaa tgcttacgtg ttccccgggg   1740

tggcactggg agtcatcgcc ggcgggatcc ggcacatccc agatgagatc ttcctcctga   1800

cagcagagca aattgcccag gaagtctctg agcagcatct gtcccagggg agactctacc   1860

caccactcag caccatccga gacgtgtctt tgagaattgc catcaaagtt ctcgactacg   1920

cgtacaaaca caacctggct tcctactacc cagagcctaa ggacaaggag gcttttgtaa   1980

gatccctggt ctacactcca gactatgact cctttacact ggacagctac acttggccca   2040

aggaagccat gaatgttcag acggtctgag gcagtctcag aggctagtat ggggctagat   2100

gaagcccaga gtaacaccca caatataaat gggttccaaa atggcccaag tgaatccttg   2160

tcgctgtgtt ttttctttta aactttctgg tgtgagagga gatgccaagg catacagtga   2220

ataaaagcct tgtctctgaa aa                                            2242


<210>  2853
<211>  604
<212>  PRT
<213>  Homosapiens

<400>  2853

Met Gly Ala Ala Leu Gly Thr Gly Thr Arg Leu Ala Pro Trp Pro Gly 
1               5                   10                  15      


Arg Ala Cys Gly Ala Leu Pro Arg Trp Thr Pro Thr Ala Pro Ala Gln 
            20                  25                  30          


Gly Cys His Ser Lys Pro Gly Pro Ala Arg Pro Val Pro Leu Lys Lys 
        35                  40                  45              


Arg Gly Tyr Asp Val Thr Arg Asn Pro His Leu Asn Lys Gly Met Ala 
    50                  55                  60                  


Phe Thr Leu Glu Glu Arg Leu Gln Leu Gly Ile His Gly Leu Ile Pro 
65                  70                  75                  80  


Pro Cys Phe Leu Ser Gln Asp Val Gln Leu Leu Arg Ile Met Arg Tyr 
                85                  90                  95      


Tyr Glu Arg Gln Gln Ser Asp Leu Asp Lys Tyr Ile Ile Leu Met Thr 
            100                 105                 110         


Leu Gln Asp Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp 
        115                 120                 125             


Val Glu Lys Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala 
    130                 135                 140                 


Cys Gln His Tyr Gly Leu Thr Phe Arg Arg Pro Arg Gly Leu Phe Ile 
145                 150                 155                 160 


Thr Ile His Asp Lys Gly His Leu Ala Thr Met Leu Asn Ser Trp Pro 
                165                 170                 175     


Glu Asp Asn Ile Lys Ala Val Val Val Thr Asp Gly Glu Arg Ile Leu 
            180                 185                 190         


Gly Leu Gly Asp Leu Gly Cys Tyr Gly Met Gly Ile Pro Val Gly Lys 
        195                 200                 205             


Leu Ala Leu Tyr Thr Ala Cys Gly Gly Val Asn Pro Gln Gln Cys Leu 
    210                 215                 220                 


Pro Val Leu Leu Asp Val Gly Thr Asn Asn Glu Glu Leu Leu Arg Asp 
225                 230                 235                 240 


Pro Leu Tyr Ile Gly Leu Lys His Gln Arg Val His Gly Lys Ala Tyr 
                245                 250                 255     


Asp Asp Leu Leu Asp Glu Phe Met Gln Ala Val Thr Asp Lys Phe Gly 
            260                 265                 270         


Ile Asn Cys Leu Ile Gln Phe Glu Asp Phe Ala Asn Ala Asn Ala Phe 
        275                 280                 285             


Arg Leu Leu Asn Lys Tyr Arg Asn Lys Tyr Cys Met Phe Asn Asp Asp 
    290                 295                 300                 


Ile Gln Gly Thr Ala Ser Val Ala Val Ala Gly Ile Leu Ala Ala Leu 
305                 310                 315                 320 


Arg Ile Thr Lys Asn Lys Leu Ser Asn His Val Phe Val Phe Gln Gly 
                325                 330                 335     


Ala Gly Glu Ala Ala Met Gly Ile Ala His Leu Leu Val Met Ala Leu 
            340                 345                 350         


Glu Lys Glu Gly Val Pro Lys Ala Glu Ala Thr Arg Lys Ile Trp Met 
        355                 360                 365             


Val Asp Ser Lys Gly Leu Ile Val Lys Gly Arg Ser His Leu Asn His 
    370                 375                 380                 


Glu Lys Glu Met Phe Ala Gln Asp His Pro Glu Val Asn Ser Leu Glu 
385                 390                 395                 400 


Glu Val Val Arg Leu Val Lys Pro Thr Ala Ile Ile Gly Val Ala Ala 
                405                 410                 415     


Ile Ala Gly Ala Phe Thr Glu Gln Ile Leu Arg Asp Met Ala Ser Phe 
            420                 425                 430         


His Glu Arg Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala 
        435                 440                 445             


Glu Cys Thr Ala Glu Lys Cys Tyr Arg Val Thr Glu Gly Arg Gly Ile 
    450                 455                 460                 


Phe Ala Ser Gly Ser Pro Phe Lys Ser Val Thr Leu Glu Asp Gly Lys 
465                 470                 475                 480 


Thr Phe Ile Pro Gly Gln Gly Asn Asn Ala Tyr Val Phe Pro Gly Val 
                485                 490                 495     


Ala Leu Gly Val Ile Ala Gly Gly Ile Arg His Ile Pro Asp Glu Ile 
            500                 505                 510         


Phe Leu Leu Thr Ala Glu Gln Ile Ala Gln Glu Val Ser Glu Gln His 
        515                 520                 525             


Leu Ser Gln Gly Arg Leu Tyr Pro Pro Leu Ser Thr Ile Arg Asp Val 
    530                 535                 540                 


Ser Leu Arg Ile Ala Ile Lys Val Leu Asp Tyr Ala Tyr Lys His Asn 
545                 550                 555                 560 


Leu Ala Ser Tyr Tyr Pro Glu Pro Lys Asp Lys Glu Ala Phe Val Arg 
                565                 570                 575     


Ser Leu Val Tyr Thr Pro Asp Tyr Asp Ser Phe Thr Leu Asp Ser Tyr 
            580                 585                 590         


Thr Trp Pro Lys Glu Ala Met Asn Val Gln Thr Val 
        595                 600                 


<210>  2854
<211>  2090
<212>  DNA
<213>  Homosapiens

<400>  2854
gctcctcacc ccgcctgctc cgcagcggga ccgcgtagac ctcagctccc cgagcagcgc     60

aggtgggcca gggaaggaga ggaccgaggt ctgccaagga ccatgggtgc cgcgctgggg    120

acaggcacgc ggctggctcc ctggccgggc cgggcctgcg gcgccctccc gcgctggaca    180

cccaccgcgc ccgcccaagg ctgccactcc aagcctggcc cggcgcgccc tgtgcccctg    240

aagaagcgcg gatacgatgt caccaggaac cctcatctca acaaggggat ggcctttacc    300

cttgaagaaa ggctgcagct tggaatccac ggcctaatcc cgccctgctt tctgagccag    360

gacgtccagc tcctccgaat catgagatat tacgagcggc agcagagtga cctggacaag    420

tacatcattc tcatgacact ccaagaccgg aacgagaagc tcttctaccg agtgctgact    480

tcggacgtgg agaagttcat gccaatcgtg tacacgccta ccgtggggct ggcctgtcag    540

cactatggcc tgactttccg caggccccgt ggactgttca tcaccattca tgacaaaggt    600

catcttgcaa caatgctgaa ttcttggcca gaagacaata ttaaggccgt ggtggtgact    660

gatggggagc gcatcctggg cctgggagac ctgggctgct acggcatggg catccctgtg    720

ggcaagctgg ccctgtacac ggcatgcgga ggggtgaacc cgcagcagtg cctccctgtg    780

ctgctggacg tcggcaccaa caatgaggag ctgctcagag accctctgta catcggcctg    840

aaacaccagc gcgtgcacgg gaaggcatac gatgacttgc tggatgagtt catgcaggct    900

gtgacagaca agtttggaat aaattgcctc atccaatttg aagacttcgc caatgccaat    960

gccttccgcc tgctcaacaa ataccgtaac aagtactgca tgttcaatga tgacatccaa   1020

ggcacagcct ccgttgctgt ggcagggatc ttggctgctc tgcgaatcac caagaacaag   1080

ctttccaatc acgtgtttgt tttccaaggt gcaggcgagg cagctatggg cattgcccac   1140

ctccttgtca tggccctaga gaaagaaggt gtaccgaagg cagaggccac aagaaagatc   1200

tggatggtgg actctaaagg gctcattgtc aaggggagga gccacctgaa ccatgaaaag   1260

gagatgtttg cccaagacca tcctgaagtc aactccctgg aggaggtggt gaggctggtg   1320

aagcccacag ccatcatagg tgttgctgcc atcgcaggag ccttcacgga gcagattctg   1380

agggacatgg cctccttcca cgagcgccct atcatctttg ccctgagcaa ccccaccagc   1440

aaggccgagt gcacggctga gaagtgctac cgggtcaccg agggccgagg gatttttgcc   1500

agtggaagtc cttttaagag tgtgactctg gaagatggca agaccttcat tcctgggcag   1560

ggaaacaatg cttacgtgtt ccccggggtg gcactgggag tcatcgccgg cgggatccgg   1620

cacatcccag atgagatctt cctcctgaca gcagagcaaa ttgcccagga agtctctgag   1680

cagcatctgt cccaggggag actctaccca ccactcagca ccatccgaga cgtgtctttg   1740

agaattgcca tcaaagttct cgactacgcg tacaaacaca acctggcttc ctactaccca   1800

gagcctaagg acaaggaggc ttttgtaaga tccctggtct acactccaga ctatgactcc   1860

tttacactgg acagctacac ttggcccaag gaagccatga atgttcagac ggtctgaggc   1920

agtctcagag gctagtatgg ggctagatga agcccagagt aacacccaca atataaatgg   1980

gttccaaaat ggcccaagtg aatccttgtc gctgtgtttt ttcttttaaa ctttctggtg   2040

tgagaggaga tgccaaggca tacagtgaat aaaagccttg tctctgaaaa              2090


<210>  2855
<211>  604
<212>  PRT
<213>  Homosapiens

<400>  2855

Met Gly Ala Ala Leu Gly Thr Gly Thr Arg Leu Ala Pro Trp Pro Gly 
1               5                   10                  15      


Arg Ala Cys Gly Ala Leu Pro Arg Trp Thr Pro Thr Ala Pro Ala Gln 
            20                  25                  30          


Gly Cys His Ser Lys Pro Gly Pro Ala Arg Pro Val Pro Leu Lys Lys 
        35                  40                  45              


Arg Gly Tyr Asp Val Thr Arg Asn Pro His Leu Asn Lys Gly Met Ala 
    50                  55                  60                  


Phe Thr Leu Glu Glu Arg Leu Gln Leu Gly Ile His Gly Leu Ile Pro 
65                  70                  75                  80  


Pro Cys Phe Leu Ser Gln Asp Val Gln Leu Leu Arg Ile Met Arg Tyr 
                85                  90                  95      


Tyr Glu Arg Gln Gln Ser Asp Leu Asp Lys Tyr Ile Ile Leu Met Thr 
            100                 105                 110         


Leu Gln Asp Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp 
        115                 120                 125             


Val Glu Lys Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala 
    130                 135                 140                 


Cys Gln His Tyr Gly Leu Thr Phe Arg Arg Pro Arg Gly Leu Phe Ile 
145                 150                 155                 160 


Thr Ile His Asp Lys Gly His Leu Ala Thr Met Leu Asn Ser Trp Pro 
                165                 170                 175     


Glu Asp Asn Ile Lys Ala Val Val Val Thr Asp Gly Glu Arg Ile Leu 
            180                 185                 190         


Gly Leu Gly Asp Leu Gly Cys Tyr Gly Met Gly Ile Pro Val Gly Lys 
        195                 200                 205             


Leu Ala Leu Tyr Thr Ala Cys Gly Gly Val Asn Pro Gln Gln Cys Leu 
    210                 215                 220                 


Pro Val Leu Leu Asp Val Gly Thr Asn Asn Glu Glu Leu Leu Arg Asp 
225                 230                 235                 240 


Pro Leu Tyr Ile Gly Leu Lys His Gln Arg Val His Gly Lys Ala Tyr 
                245                 250                 255     


Asp Asp Leu Leu Asp Glu Phe Met Gln Ala Val Thr Asp Lys Phe Gly 
            260                 265                 270         


Ile Asn Cys Leu Ile Gln Phe Glu Asp Phe Ala Asn Ala Asn Ala Phe 
        275                 280                 285             


Arg Leu Leu Asn Lys Tyr Arg Asn Lys Tyr Cys Met Phe Asn Asp Asp 
    290                 295                 300                 


Ile Gln Gly Thr Ala Ser Val Ala Val Ala Gly Ile Leu Ala Ala Leu 
305                 310                 315                 320 


Arg Ile Thr Lys Asn Lys Leu Ser Asn His Val Phe Val Phe Gln Gly 
                325                 330                 335     


Ala Gly Glu Ala Ala Met Gly Ile Ala His Leu Leu Val Met Ala Leu 
            340                 345                 350         


Glu Lys Glu Gly Val Pro Lys Ala Glu Ala Thr Arg Lys Ile Trp Met 
        355                 360                 365             


Val Asp Ser Lys Gly Leu Ile Val Lys Gly Arg Ser His Leu Asn His 
    370                 375                 380                 


Glu Lys Glu Met Phe Ala Gln Asp His Pro Glu Val Asn Ser Leu Glu 
385                 390                 395                 400 


Glu Val Val Arg Leu Val Lys Pro Thr Ala Ile Ile Gly Val Ala Ala 
                405                 410                 415     


Ile Ala Gly Ala Phe Thr Glu Gln Ile Leu Arg Asp Met Ala Ser Phe 
            420                 425                 430         


His Glu Arg Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala 
        435                 440                 445             


Glu Cys Thr Ala Glu Lys Cys Tyr Arg Val Thr Glu Gly Arg Gly Ile 
    450                 455                 460                 


Phe Ala Ser Gly Ser Pro Phe Lys Ser Val Thr Leu Glu Asp Gly Lys 
465                 470                 475                 480 


Thr Phe Ile Pro Gly Gln Gly Asn Asn Ala Tyr Val Phe Pro Gly Val 
                485                 490                 495     


Ala Leu Gly Val Ile Ala Gly Gly Ile Arg His Ile Pro Asp Glu Ile 
            500                 505                 510         


Phe Leu Leu Thr Ala Glu Gln Ile Ala Gln Glu Val Ser Glu Gln His 
        515                 520                 525             


Leu Ser Gln Gly Arg Leu Tyr Pro Pro Leu Ser Thr Ile Arg Asp Val 
    530                 535                 540                 


Ser Leu Arg Ile Ala Ile Lys Val Leu Asp Tyr Ala Tyr Lys His Asn 
545                 550                 555                 560 


Leu Ala Ser Tyr Tyr Pro Glu Pro Lys Asp Lys Glu Ala Phe Val Arg 
                565                 570                 575     


Ser Leu Val Tyr Thr Pro Asp Tyr Asp Ser Phe Thr Leu Asp Ser Tyr 
            580                 585                 590         


Thr Trp Pro Lys Glu Ala Met Asn Val Gln Thr Val 
        595                 600                 


<210>  2856
<211>  3750
<212>  DNA
<213>  Homosapiens

<400>  2856
gcgctgctcg ccagcttgct cgcactcggc tgtgcggcgg ggcaggcatg ggagccgcgc     60

gctctctccc ggcgcccaca cctgtctgag cggcgcagcg agccgcggcc cgggcgggct    120

gctcggcgcg gaacagtgct cggcatggca gggattccag ggctcctctt ccttctcttc    180

tttctgctct gtgctgttgg gcaagtgagc ccttacagtg ccccctggaa acccacttgg    240

cctgcatacc gcctccctgt cgtcttgccc cagtctaccc tcaatttagc caagccagac    300

tttggagccg aagccaaatt agaagtatct tcttcatgtg gaccccagtg tcataaggga    360

actccactgc ccacttacga agaggccaag caatatctgt cttatgaaac gctctatgcc    420

aatggcagcc gcacagagac gcaggtgggc atctacatcc tcagcagtag tggagatggg    480

gcccaacacc gagactcagg gtcttcagga aagtctcgaa ggaagcggca gatttatggc    540

tatgacagca ggttcagcat ttttgggaag gacttcctgc tcaactaccc tttctcaaca    600

tcagtgaagt tatccacggg ctgcaccggc accctggtgg cagagaagca tgtcctcaca    660

gctgcccact gcatacacga tggaaaaacc tatgtgaaag gaacccagaa gcttcgagtg    720

ggcttcctaa agcccaagtt taaagatggt ggtcgagggg ccaacgactc cacttcagcc    780

atgcccgagc agatgaaatt tcagtggatc cgggtgaaac gcacccatgt gcccaagggt    840

tggatcaagg gcaatgccaa tgacatcggc atggattatg attatgccct cctggaactc    900

aaaaagcccc acaagagaaa atttatgaag attggggtga gccctcctgc taagcagctg    960

ccagggggca gaattcactt ctctggttat gacaatgacc gaccaggcaa tttggtgtat   1020

cgcttctgtg acgtcaaaga cgagacctat gacttgctct accagcaatg cgatgcccag   1080

ccaggggcca gcgggtctgg ggtctatgtg aggatgtgga agagacagca gcagaagtgg   1140

gagcgaaaaa ttattggcat tttttcaggg caccagtggg tggacatgaa tggttcccca   1200

caggatttca acgtggctgt cagaatcact cctctcaaat atgcccagat ttgctattgg   1260

attaaaggaa actacctgga ttgtagggag gggtgacaca gtgttccctc ctggcagcaa   1320

ttaagggtct tcatgttctt attttaggag aggccaaatt gttttttgtc attggcgtgc   1380

acacgtgtgt gtgtgtgtgt gtgtgtgtgt aaggtgtctt ataatctttt acctatttct   1440

tacaattgca agatgactgg ctttactatt tgaaaactgg tttgtgtatc atatcatata   1500

tcatttaagc agtttgaagg catacttttg catagaaata aaaaaaatac tgatttgggg   1560

caatgaggaa tatttgacaa ttaagttaat cttcacgttt ttgcaaactt tgatttttat   1620

ttcatctgaa cttgtttcaa agatttatat taaatatttg gcatacaaga gatatgaatt   1680

cttatatgtg tgcatgtgtg ttttcttctg agattcatct tggtggtggg tttttttgtt   1740

tttttaattc agtgcctgat ctttaatgct tccataaggc agtgttccca tttaggaact   1800

ttgacagcat ttgttaggca gaatattttg gatttggagg catttgcatg gtagtctttg   1860

aacagtaaaa tgatgtgttg actatactga tacacatatt aaactatacc ttatagtaaa   1920

ccagtatccc aagctgcttt tagttccaaa aatagtttct tttccaaagg ttgttgctct   1980

actttgtagg aagtctttgc atatggccct cccaacttta aagtcatacc agagtggcca   2040

agagtgttta tcccaaccct tccatttaac aggatttcac tcacatttct ggaactagct   2100

atttttcaga agacaataat cagggcttaa ttagaacagg ctgtatttcc tcccagcaaa   2160

cagttgtggc cacactaaaa acaatcatag cattttaccc ctggattata gcacatctca   2220

tgttttatca tttggatgga gtaatttaaa atgaattaaa ttccagagaa caatggaagc   2280

attgcctggc agatgtcaca acagaataac cacttgtttg gagcctggca cagtcctcca   2340

gcctgatcaa aaattattct gcatagtttt cagtgtgctt tctgggagct atgtacttct   2400

tcaatttgga aacttttctc tctcatttat agtgaaaata cttggaagtt actttaagaa   2460

aaccagtgtg gcctttttcc ctctagcttt aaaagggccg cttttgctgg aatgctctag   2520

gttatagata aacaattagg tataatagca aaaatgaaaa ttggaagaat gcaaaatgga   2580

tcagaatcat gccttccaat aaaggccttt acacatgttt tatcaatatg attatcaaat   2640

cacagcatat acagaaaaga cttggactta ttgtatgttt ttattttatg gctctcggcc   2700

taagcacttc tttctaaatg tatcggagaa aaaatcaaat ggactacaag cacgtgtttg   2760

ctgtgcttgc accccaggta aacctgcatt gtagcaattt gtaaggatat tcagatggag   2820

cactgtcact tagacattct ctgggggatt ttctgcttgt ctttcttgag ctttttggaa   2880

ggataattct gataaggcac tcaagaaacg tacaaccaca gtgctttctt caaatcatat   2940

gagaaatact atgcatagca aggagatgca gagccgccag gaaaattctg agttccagca   3000

caattttctt tggaatctaa caggaatcta gcctgaggaa gaagggaggt ctccatttct   3060

atgtctggta tttgggggtt ttgtttgttt ttgctttagc ttggtgaaaa aaagttcact   3120

gaacaccaag accagaatgg atttttttaa aaaaatagat gttccttttg tgaagcacct   3180

tgattccttg attttgattt tttgcaaagt tagacaatgg cacaaagtca aaatgaaatc   3240

aatgtttagt tcacaagtag atgtaattta ctaaagaatg atacacccat atgctatata   3300

cagcttaact cacagaactg taaaagaaaa ttataaaata attcaacatg tccatctttt   3360

tagtgataat aaaagaaagc atggtattaa actatcatag aagtagacag aaaaagaaaa   3420

aaggactcat ggcattatta atataattag tgctttacat gtgttagtta tacatattag   3480

aagcatattt gcctagtaag gctagtagaa ccacatttcc caaagtgtgc tccttaaaca   3540

ctcatgcctt atgattttct accaaaagta aaaagggttg tattaagtca gaggaagatg   3600

cctctccatt ttccctctct ttatcagagg ttcacatgcc tgtctgcaca ttaaaagctc   3660

tgggaagacc tgttgtaaag ggacaagttg aggttgtaaa atctgcattt aaataaacat   3720

ctttgatcac aaaaaaaaaa aaaaaaaaaa                                    3750


<210>  2857
<211>  383
<212>  PRT
<213>  Homosapiens

<400>  2857

Met Ala Gly Ile Pro Gly Leu Leu Phe Leu Leu Phe Phe Leu Leu Cys 
1               5                   10                  15      


Ala Val Gly Gln Val Ser Pro Tyr Ser Ala Pro Trp Lys Pro Thr Trp 
            20                  25                  30          


Pro Ala Tyr Arg Leu Pro Val Val Leu Pro Gln Ser Thr Leu Asn Leu 
        35                  40                  45              


Ala Lys Pro Asp Phe Gly Ala Glu Ala Lys Leu Glu Val Ser Ser Ser 
    50                  55                  60                  


Cys Gly Pro Gln Cys His Lys Gly Thr Pro Leu Pro Thr Tyr Glu Glu 
65                  70                  75                  80  


Ala Lys Gln Tyr Leu Ser Tyr Glu Thr Leu Tyr Ala Asn Gly Ser Arg 
                85                  90                  95      


Thr Glu Thr Gln Val Gly Ile Tyr Ile Leu Ser Ser Ser Gly Asp Gly 
            100                 105                 110         


Ala Gln His Arg Asp Ser Gly Ser Ser Gly Lys Ser Arg Arg Lys Arg 
        115                 120                 125             


Gln Ile Tyr Gly Tyr Asp Ser Arg Phe Ser Ile Phe Gly Lys Asp Phe 
    130                 135                 140                 


Leu Leu Asn Tyr Pro Phe Ser Thr Ser Val Lys Leu Ser Thr Gly Cys 
145                 150                 155                 160 


Thr Gly Thr Leu Val Ala Glu Lys His Val Leu Thr Ala Ala His Cys 
                165                 170                 175     


Ile His Asp Gly Lys Thr Tyr Val Lys Gly Thr Gln Lys Leu Arg Val 
            180                 185                 190         


Gly Phe Leu Lys Pro Lys Phe Lys Asp Gly Gly Arg Gly Ala Asn Asp 
        195                 200                 205             


Ser Thr Ser Ala Met Pro Glu Gln Met Lys Phe Gln Trp Ile Arg Val 
    210                 215                 220                 


Lys Arg Thr His Val Pro Lys Gly Trp Ile Lys Gly Asn Ala Asn Asp 
225                 230                 235                 240 


Ile Gly Met Asp Tyr Asp Tyr Ala Leu Leu Glu Leu Lys Lys Pro His 
                245                 250                 255     


Lys Arg Lys Phe Met Lys Ile Gly Val Ser Pro Pro Ala Lys Gln Leu 
            260                 265                 270         


Pro Gly Gly Arg Ile His Phe Ser Gly Tyr Asp Asn Asp Arg Pro Gly 
        275                 280                 285             


Asn Leu Val Tyr Arg Phe Cys Asp Val Lys Asp Glu Thr Tyr Asp Leu 
    290                 295                 300                 


Leu Tyr Gln Gln Cys Asp Ala Gln Pro Gly Ala Ser Gly Ser Gly Val 
305                 310                 315                 320 


Tyr Val Arg Met Trp Lys Arg Gln Gln Gln Lys Trp Glu Arg Lys Ile 
                325                 330                 335     


Ile Gly Ile Phe Ser Gly His Gln Trp Val Asp Met Asn Gly Ser Pro 
            340                 345                 350         


Gln Asp Phe Asn Val Ala Val Arg Ile Thr Pro Leu Lys Tyr Ala Gln 
        355                 360                 365             


Ile Cys Tyr Trp Ile Lys Gly Asn Tyr Leu Asp Cys Arg Glu Gly 
    370                 375                 380             


<210>  2858
<211>  4518
<212>  DNA
<213>  Homosapiens

<400>  2858
acaaaatggt cctttagaaa atacatctga attgctggct aatttcttga tttgcgactc     60

aacgtaggac atcgcttgtt cgtagctatc agaaccctcc tgaattttcc ccaccatgct    120

atctttattg gcttgaactc ctttcctaaa atggtccttc tgttgatcct gtcagtctta    180

cttttgaaag aagatgtccg tgggagtgca cagtccagtg agaggagggt ggtggctcac    240

atgccgggtg acatcattat tggagctctc ttttctgttc atcaccagcc tactgtggac    300

aaagttcatg agaggaagtg tggggcggtc cgtgaacagt atggcattca gagagtggag    360

gccatgctgc ataccctgga aaggatcaat tcagacccca cactcttgcc caacatcaca    420

ctgggctgtg agataaggga ctcctgctgg cattcggctg tggccctaga gcagagcatt    480

gagttcataa gagattccct catttcttca gaagaggaag aaggcttggt acgctgtgtg    540

gatggctcct cctcttcctt ccgctccaag aagcccatag taggggtcat tgggcctggc    600

tccagttctg tagccattca ggtccagaat ttgctccagc ttttcaacat acctcagatt    660

gcttactcag caaccagcat ggatctgagt gacaagactc tgttcaaata tttcatgagg    720

gttgtgcctt cagatgctca gcaggcaagg gccatggtgg acatagtgaa gaggtacaac    780

tggacctatg tatcagccgt gcacacagaa ggcaactatg gagaaagtgg gatggaagcc    840

ttcaaagata tgtcagcgaa ggaagggatt tgcatcgccc actcttacaa aatctacagt    900

aatgcagggg agcagagctt tgataagctg ctgaagaagc tcacaagtca cttgcccaag    960

gcccgggtgg tggcctgctt ctgtgagggc atgacggtga gaggtctgct gatggccatg   1020

aggcgcctgg gtctagcggg agaatttctg cttctgggca gtgatggctg ggctgacagg   1080

tatgatgtga cagatggata tcagcgagaa gctgttggtg gcatcacaat caagctccaa   1140

tctcccgatg tcaagtggtt tgatgattat tatctgaagc tccggccaga aacaaaccac   1200

cgaaaccctt ggtttcaaga attttggcag catcgttttc agtgccgact ggaagggttt   1260

ccacaggaga acagcaaata caacaagact tgcaatagtt ctctgactct gaaaacacat   1320

catgttcagg attccaaaat gggatttgtg atcaacgcca tctattcgat ggcctatggg   1380

ctccacaaca tgcagatgtc cctctgccca ggctatgcag gactctgtga tgccatgaag   1440

ccaattgatg gacggaaact tttggagtcc ctgatgaaaa ccaattttac tggggtttct   1500

ggagatacga tcctattcga tgagaatgga gactctccag gaaggtatga aataatgaat   1560

ttcaaggaaa tgggaaaaga ttactttgat tatatcaacg ttggaagttg ggacaatgga   1620

gaattaaaaa tggatgatga tgaagtatgg tccaagaaaa gcaacatcat cagatctgtg   1680

tgcagtgaac catgtgagaa aggccagatc aaggtgatcc gaaagggaga agtcagctgt   1740

tgttggacct gtacaccttg taaggagaat gagtatgtct ttgatgagta cacatgcaag   1800

gcatgccaac tggggtcttg gcccactgat gatctcacag gttgtgactt gatcccagta   1860

cagtatcttc gatggggtga ccctgaaccc attgcagctg tggtgtttgc ctgccttggc   1920

ctcctggcca ccctgtttgt tactgtagtc ttcatcattt accgtgatac accagtagtc   1980

aagtcctcaa gcagggaact ctgctacatt atccttgctg gcatctgcct gggctactta   2040

tgtaccttct gcctcattgc gaagcccaaa cagatttact gctaccttca gagaattggc   2100

attggtctct ccccagccat gagctactca gcccttgtaa caaagaccaa ccgtattgca   2160

aggatcctgg ctggcagcaa gaagaagatc tgtaccaaaa agcccagatt catgagtgcc   2220

tgtgcccagc tagtgattgc tttcattctc atatgcatcc agttgggcat catcgttgcc   2280

ctctttataa tggagcctcc tgacataatg catgactacc caagcattcg agaagtctac   2340

ctgatctgta acaccaccaa cctaggagtt gtcactccac ttggatacaa tggattgttg   2400

attttgagct gcaccttcta tgcgttcaag accagaaatg ttccagctaa cttcaacgag   2460

gccaagtata tcgccttcac aatgtacacg acctgcatta tatggctagc ttttgtgcca   2520

atctactttg gcagcaacta caaaatcatc accatgtgtt tctcggtcag cctcagtgcc   2580

acagtggccc taggctgcat gtttgtgccg aaggtgtaca tcatcctggc caaaccagag   2640

agaaacgtgc gcagcgcctt caccacatct accgtggtgc gcatgcatgt aggggatggc   2700

aagtcatcct ccgcagccag cagatccagc agcctagtca acctgtggaa gagaaggggc   2760

tcctctgggg aaaccttaag ttccaatgga aaatccgtca cgtgggccca gaatgagaag   2820

agcagccggg ggcagcacct gtggcagcgc ctgtccatcc acatcaacaa gaaagaaaac   2880

cccaaccaaa cggccgtcat caagcccttc cccaagagca cggagagccg tggcctgggc   2940

gctggcgctg gcgcaggcgg gagcgctggg ggcgtggggg ccacgggcgg tgcgggctgc   3000

gcaggcgccg gcccaggcgg gcccgagtcc ccagacgccg gccccaaggc gctgtatgat   3060

gtggccgagg ctgaggagca cttcccggcg cccgcgcggc cgcgctcacc gtcgcccatc   3120

agcacgctga gccaccgcgc gggctcggcc agccgcacgg acgacgatgt gccgtcgctg   3180

cactcggagc ctgtggcgcg cagcagctcc tcgcagggct ccctcatgga gcagatcagc   3240

agtgtggtca cccgcttcac ggccaacatc agcgagctca actccatgat gctgtccacc   3300

gcggccccca gccccggcgt cggcgccccg ctctgctcgt cctacctgat ccccaaagag   3360

atccagttgc ccacgaccat gacgaccttt gccgaaatcc agcctctgcc ggccatcgaa   3420

gtcacgggcg gcgcgcagcc cgcggcaggg gcgcaggcgg ctggggacgc ggcccgggag   3480

agccccgcgg ccggtcccga ggctgcggcc gccaagccag acctggagga gctggtggct   3540

ctcaccccgc cgtccccctt cagagactcg gtggactcgg ggagcacaac ccccaactcg   3600

ccagtgtccg agtcggccct ctgtatcccg tcgtctccca aatatgacac tcttatcata   3660

agagattaca ctcagagctc ctcgtcgttg tgaatgtccc tggaaagcac gccggcctgc   3720

gcgtgcggag cggagccccc cgtgttcaca cacacacaat ggcaagcata gtcgcctggt   3780

tacggcccag ggggaatatg ccaagggacc ccttaatgga aacacagatc agtagtgcta   3840

tctcatgaca accacaagaa accgacgaca aatcttttgc gagattttct tctagtggct   3900

tagaaacatg gcttttaaga aacacggtga tatctttgag ggtgacaagg cgtctcttca   3960

aacagttcca taccaactgc tttgctctag ggaagcagtg cgtgtgaaac agcgtaacgg   4020

agggtgaaga gcatagttaa taagcaactg taaaaagttt tatttgttta ctttaattct   4080

tttcccctgt aaaaagtttt atttgtttac tttaattctt ttcccagaaa agagtctttg   4140

attcaccaaa catgaatgta cattttctaa caaactcaaa atctgggacc aaaacatcaa   4200

cttttttctt tcttttttct ttctttttgt tttttctttc ctgtaaagac cttgaaaaga   4260

ccttgaaaag cagtaacttg ggtccagtat ttacggaggc gttgtgaatg tgtcccatgc   4320

ataacacact actggatagt gagtcgtgcg ctaatgtact acgtagggct tctaccagag   4380

attttcctct ccaattgggt tgtgaaatac tcttccaaaa gcctgcatcg gggattccac   4440

ctacttattt cagattcacc tccattaacc aagaaaacca gtggaagatt tcttgactat   4500

ttcaccatgt tgccaatc                                                 4518


<210>  2859
<211>  1180
<212>  PRT
<213>  Homosapiens

<400>  2859

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Ser Ser Asn Gly 
865                 870                 875                 880 


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
                885                 890                 895     


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
            900                 905                 910         


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
        915                 920                 925             


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Val Gly Ala 
    930                 935                 940                 


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Ser 
945                 950                 955                 960 


Pro Asp Ala Gly Pro Lys Ala Leu Tyr Asp Val Ala Glu Ala Glu Glu 
                965                 970                 975     


His Phe Pro Ala Pro Ala Arg Pro Arg Ser Pro Ser Pro Ile Ser Thr 
            980                 985                 990         


Leu Ser His Arg Ala Gly Ser Ala  Ser Arg Thr Asp Asp  Asp Val Pro 
        995                 1000                 1005             


Ser Leu  His Ser Glu Pro Val  Ala Arg Ser Ser Ser  Ser Gln Gly 
    1010                 1015                 1020             


Ser Leu  Met Glu Gln Ile Ser  Ser Val Val Thr Arg  Phe Thr Ala 
    1025                 1030                 1035             


Asn Ile  Ser Glu Leu Asn Ser  Met Met Leu Ser Thr  Ala Ala Pro 
    1040                 1045                 1050             


Ser Pro  Gly Val Gly Ala Pro  Leu Cys Ser Ser Tyr  Leu Ile Pro 
    1055                 1060                 1065             


Lys Glu  Ile Gln Leu Pro Thr  Thr Met Thr Thr Phe  Ala Glu Ile 
    1070                 1075                 1080             


Gln Pro  Leu Pro Ala Ile Glu  Val Thr Gly Gly Ala  Gln Pro Ala 
    1085                 1090                 1095             


Ala Gly  Ala Gln Ala Ala Gly  Asp Ala Ala Arg Glu  Ser Pro Ala 
    1100                 1105                 1110             


Ala Gly  Pro Glu Ala Ala Ala  Ala Lys Pro Asp Leu  Glu Glu Leu 
    1115                 1120                 1125             


Val Ala  Leu Thr Pro Pro Ser  Pro Phe Arg Asp Ser  Val Asp Ser 
    1130                 1135                 1140             


Gly Ser  Thr Thr Pro Asn Ser  Pro Val Ser Glu Ser  Ala Leu Cys 
    1145                 1150                 1155             


Ile Pro  Ser Ser Pro Lys Tyr  Asp Thr Leu Ile Ile  Arg Asp Tyr 
    1160                 1165                 1170             


Thr Gln  Ser Ser Ser Ser Leu  
    1175                 1180 


<210>  2860
<211>  1964
<212>  DNA
<213>  Homosapiens

<400>  2860
atcactgtag tagtagctgg aaagagaaat ctgtgactcc aattagccag ttcctgcaga     60

ccttgtgagg actagaggaa gaatgctcct ggctgttttg tactgcctgc tgtggagttt    120

ccagacctcc gctggccatt tccctagagc ctgtgtctcc tctaagaacc tgatggagaa    180

ggaatgctgt ccaccgtgga gcggggacag gagtccctgt ggccagcttt caggcagagg    240

ttcctgtcag aatatccttc tgtccaatgc accacttggg cctcaatttc ccttcacagg    300

ggtggatgac cgggagtcgt ggccttccgt cttttataat aggacctgcc agtgctctgg    360

caacttcatg ggattcaact gtggaaactg caagtttggc ttttggggac caaactgcac    420

agagagacga ctcttggtga gaagaaacat cttcgatttg agtgccccag agaaggacaa    480

attttttgcc tacctcactt tagcaaagca taccatcagc tcagactatg tcatccccat    540

agggacctat ggccaaatga aaaatggatc aacacccatg tttaacgaca tcaatattta    600

tgacctcttt gtctggatgc attattatgt gtcaatggat gcactgcttg ggggatctga    660

aatctggaga gacattgatt ttgcccatga agcaccagct tttctgcctt ggcatagact    720

cttcttgttg cggtgggaac aagaaatcca gaagctgaca ggagatgaaa acttcactat    780

tccatattgg gactggcggg atgcagaaaa gtgtgacatt tgcacagatg agtacatggg    840

aggtcagcac cccacaaatc ctaacttact cagcccagca tcattcttct cctcttggca    900

gattgtctgt agccgattgg aggagtacaa cagccatcag tctttatgca atggaacgcc    960

cgagggacct ttacggcgta atcctggaaa ccatgacaaa tccagaaccc caaggctccc   1020

ctcttcagct gatgtagaat tttgcctgag tttgacccaa tatgaatctg gttccatgga   1080

taaagctgcc aatttcagct ttagaaatac actggaagga tttgctagtc cacttactgg   1140

gatagcggat gcctctcaaa gcagcatgca caatgccttg cacatctata tgaatggaac   1200

aatgtcccag gtacagggat ctgccaacga tcctatcttc cttcttcacc atgcatttgt   1260

tgacagtatt tttgagcagt ggctccgaag gcaccgtcct cttcaagaag tttatccaga   1320

agccaatgca cccattggac ataaccggga atcctacatg gttcctttta taccactgta   1380

cagaaatggt gatttcttta tttcatccaa agatctgggc tatgactata gctatctaca   1440

agattcagac ccagactctt ttcaagacta cattaagtcc tatttggaac aagcgagtcg   1500

gatctggtca tggctccttg gggcggcgat ggtaggggcc gtcctcactg ccctgctggc   1560

agggcttgtg agcttgctgt gtcgtcacaa gagaaagcag cttcctgaag aaaagcagcc   1620

actcctcatg gagaaagagg attaccacag cttgtatcag agccatttat aaaaggctta   1680

ggcaatagag tagggccaaa aagcctgacc tcactctaac tcaaagtaat gtccaggttc   1740

ccagagaata tctgctggta tttttctgta aagaccattt gcaaaattgt aacctaatac   1800

aaagtgtagc cttcttccaa ctcaggtaga acacacctgt ctttgtcttg ctgttttcac   1860

tcagcccttt taacattttc ccctaagccc atatgtctaa ggaaaggatg ctatttggta   1920

atgaggaact gttatttgta tgtgaattaa agtgctctta tttt                    1964


<210>  2861
<211>  529
<212>  PRT
<213>  Homosapiens

<400>  2861

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  2862
<211>  4164
<212>  DNA
<213>  Homosapiens

<400>  2862
aattcgcctc tgccacaggc tgcaaaggac ccgaggaacc gctctctctg aactgtgctg     60

atgggcagga ggatgggaga caggaattga gagtcacaga ggaaggacag tggagtctgg    120

catcttattg gtgtctttaa aggattgcca tttaatgcca ttcaagatct actaagcatc    180

atttttgcat gactactgca aaaggattac tttacagata ccagttcctt tgtcaagagc    240

atactttgga ccctgttttc agaaagcagg gcactcttta atgaagaaac accagagctg    300

ttaaacacat tgagacacag aagattctag tgactgagga tggcttcctc ttggaaacta    360

atgctgtttc tgtcagtcac catgtgtctt tcagagtatt caaaatctct tcctggtctc    420

tccacttcat atgctgcttt gttaagaatt aagaagagtt catcttcatc tctctttggt    480

tccaaaacca gaccacgata cagcagccct tcattaggaa cactgagtgc ttcttcaccc    540

agctggctag gggcagctca gaattattat tcccccatca atctttatca ttcctcagat    600

gccttcaaac aagatgaaag tgtggactat gggccagttt ttgtgcaaga accagatgat    660

attatttttc caactgattc tgatgaaaag aaggtagcat tgaattgtga agttcgtggc    720

aatccagttc ccagttacag atggcttcga aatggaacag aaatagatct ggaaagtgat    780

tatcgctaca gtttgataga tggcaccttc attataagca atccaagtga agcaaaggat    840

tctggtcatt atcagtgttt agcaaccaac actgtgggga gtattcttag tagagaagct    900

acactgcagt ttgcctatct gggaaatttt agtggccgga caagaagtgc agtctctgtg    960

agggaaggcc agggtgtcgt tctgatgtgc tctcctccgc cacattcacc agagatcatc   1020

tatagctggg tatttaatga gttcccttcc tttgtggcgg aagacagccg gcggttcatc   1080

tcccaggaga caggcaacct ttatatttct aaagtccaaa catcagatgt tggcagctat   1140

atttgtctgg tgaaaaacac agtgacgaat gctagagtcc ttagtcctcc aacgccactc   1200

actctgcgta atgatggtgt gatgggagaa tatgagccga aaattgaggt ccattttcct   1260

ttcacggtta cagctgctaa aggaacaact gttaagatgg aatgctttgc acttggcaac   1320

cccgttccaa caatcacatg gatgaaggtt aatggttata ttcctagtaa ggcacgtctg   1380

cggaaatctc aggcggtgct ggaaataccg aatgtacagc tggatgatgc aggcatttat   1440

gagtgcagag ctgaaaactc acgtggaaaa aattcctttc gtggacaatt acaagtatac   1500

acctacccac actgggtaga aaaactgaat gatactcagt tagacagtgg gagccctctc   1560

cgatgggaat gtaaggctac tggaaaaccc agacccacgt atcgttggct gaagaatgga   1620

gtacccctct cacctcagag tagggttgag atggttaatg gagtattgat gatccacaat   1680

gtgaatcaat cagatgctgg aatgtatcag tgtttggctg aaaataagta tggagccatt   1740

tacgctagtg ctgagctgaa gattctagct tcagctccca cttttgcact gaatcaactg   1800

aagaaaacaa taattgttac caaagaccaa gaagttgtca tagagtgcaa accccaaggc   1860

tctccaaaac caaccatctc ttggaagaaa ggagacagag cagttagaga aaacaaaaga   1920

atagctattc ttccagacgg gagtctacgg atcctaaatg cttccaaatc agacgaggga   1980

aagtacgttt gccgagggga aaacgtcttt ggttctgctg aaattatagc ttcgctatct   2040

gtaaaagaac ctacaaggat agaacttact cctaaaagaa cagaattgac agtgggagaa   2100

agcattgtcc ttaattgcaa agcaattcac gatgctagtt tggatgtcac tttctactgg   2160

actctgaaag gacagcctat tgatttcgag gaagagggtg gacattttga aagcatcagg   2220

gcccaagcat cctctgcaga tttaatgatc aggaacatcc ttctgatgca tgctgggaga   2280

tatggctgca gggtacagac cacagcagac agtgtgtcag atgaggcaga acttcttgtt   2340

aggggacccc caggcccacc tgggatagta attgttgagg aaataaccga aagtacggcc   2400

acactgtcct ggagcccagc agctgacaac cacagcccaa tctcctccta caaccttcaa   2460

gctcgcagcc cattttccct gggctggcaa acagtaaaga cagtcccaga aatcataaca   2520

ggggacatgg agtcagccat ggctgtggac ctaaatccct gggtggaata tgaatttcga   2580

gtggtagcca ccaaccctat tgggacagga gatccaagca ccccatctcg aatgatccgc   2640

acaaatgaag cagttccgaa gacagcaccc accaatgtaa gcggaagaag tggaagaagg   2700

catgagttag tcattgcctg ggagccagta tctgaagagt ttcagaatgg ggaaggcttc   2760

ggctatattg tggctttcag acccaatgga acacgtggct ggaaggaaaa aatggtgaca   2820

tcctctgaag cttccaaatt catttatcga gatgaaagtg tccctcctct tactcccttt   2880

gaagtgaaag ttggcgttta taacaataaa ggagatgggc cttttagtca aattgtggtc   2940

atctgttcag ctgaaggaga acccagtgct gctcccacag atgtcaaggc gacaagtgtg   3000

tctgtgtcag agattcttgt tgcatggaaa cacattaaag agagtctagg aagaccacag   3060

ggatttgagg ttggttactg gaaagacatg gaacaggaag atacagcaga aacagtcaaa   3120

actagaggga atgagtcttt cgtcatccta acaggattag aaggaaatac gttatatcac   3180

ttcacagtga gggcttacaa tggagctgga tatgggccac ctagcagtga agtgagtgca   3240

accaccaaga aatcccctcc tagtcaagca cctagcaacc tcaggtggga gcagcaaggc   3300

tctcaggttt ctctgggctg ggaacccgtc ataccattag ccaacgaatc tgaagttgtg   3360

ggttacaagg ttttttatag gcaagagggt cacagcaaca gccaagttat tgaaacacag   3420

aaacttcaag cagtagtacc actcccagat gctggagtct atattattga agttcgagca   3480

tatagtgaag gaggagatgg aacagctagt tctcaaatta gggtaccatc atattcaggt   3540

ggaaaaatca caagtgcaca gtcgaccctt cactctctct ccacatcttc gtcatcagtc   3600

accttgctct tggcattgat gattccttca acttcctggt gaaaactgct gacttaattt   3660

gcttttgttt gctttagctt ggtaacagcg gtgaatagag tgtagtgtaa gtggagaacc   3720

aggatcctga gatgagcttg agctttaaaa acttgggact atacatggtg aacttacagg   3780

aggttagggg ggaaatatta cttatccatc aggtttctct ttggtttttg taaacggaga   3840

ggacagttct tagtccagta aaaatatgca gattgtatgt aatgaatttt tgtaaacaaa   3900

ggtaatttct gtcaaatgta ttctttactt ttttaatatg ttgggatttt attttatatc   3960

tgatgactcc gagtgtgtgc catccatttg ttaagtaact ggcctttagc agatctgttt   4020

caaaaacaaa tacaaaaatg agaatgaaaa gtttgcttaa gactaagtcc agtgtttttc   4080

attttccctt tggctgaata tttcaattga caaaccagca ggacatatga aaaatgcttc   4140

agtgatgtgg tccattataa gata                                          4164


<210>  2863
<211>  1100
<212>  PRT
<213>  Homosapiens

<400>  2863

Met Ala Ser Ser Trp Lys Leu Met Leu Phe Leu Ser Val Thr Met Cys 
1               5                   10                  15      


Leu Ser Glu Tyr Ser Lys Ser Leu Pro Gly Leu Ser Thr Ser Tyr Ala 
            20                  25                  30          


Ala Leu Leu Arg Ile Lys Lys Ser Ser Ser Ser Ser Leu Phe Gly Ser 
        35                  40                  45              


Lys Thr Arg Pro Arg Tyr Ser Ser Pro Ser Leu Gly Thr Leu Ser Ala 
    50                  55                  60                  


Ser Ser Pro Ser Trp Leu Gly Ala Ala Gln Asn Tyr Tyr Ser Pro Ile 
65                  70                  75                  80  


Asn Leu Tyr His Ser Ser Asp Ala Phe Lys Gln Asp Glu Ser Val Asp 
                85                  90                  95      


Tyr Gly Pro Val Phe Val Gln Glu Pro Asp Asp Ile Ile Phe Pro Thr 
            100                 105                 110         


Asp Ser Asp Glu Lys Lys Val Ala Leu Asn Cys Glu Val Arg Gly Asn 
        115                 120                 125             


Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn Gly Thr Glu Ile Asp Leu 
    130                 135                 140                 


Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp Gly Thr Phe Ile Ile Ser 
145                 150                 155                 160 


Asn Pro Ser Glu Ala Lys Asp Ser Gly His Tyr Gln Cys Leu Ala Thr 
                165                 170                 175     


Asn Thr Val Gly Ser Ile Leu Ser Arg Glu Ala Thr Leu Gln Phe Ala 
            180                 185                 190         


Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg Ser Ala Val Ser Val Arg 
        195                 200                 205             


Glu Gly Gln Gly Val Val Leu Met Cys Ser Pro Pro Pro His Ser Pro 
    210                 215                 220                 


Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu Phe Pro Ser Phe Val Ala 
225                 230                 235                 240 


Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu Thr Gly Asn Leu Tyr Ile 
                245                 250                 255     


Ser Lys Val Gln Thr Ser Asp Val Gly Ser Tyr Ile Cys Leu Val Lys 
            260                 265                 270         


Asn Thr Val Thr Asn Ala Arg Val Leu Ser Pro Pro Thr Pro Leu Thr 
        275                 280                 285             


Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu Pro Lys Ile Glu Val 
    290                 295                 300                 


His Phe Pro Phe Thr Val Thr Ala Ala Lys Gly Thr Thr Val Lys Met 
305                 310                 315                 320 


Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr Ile Thr Trp Met Lys 
                325                 330                 335     


Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg Leu Arg Lys Ser Gln Ala 
            340                 345                 350         


Val Leu Glu Ile Pro Asn Val Gln Leu Asp Asp Ala Gly Ile Tyr Glu 
        355                 360                 365             


Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn Ser Phe Arg Gly Gln Leu 
    370                 375                 380                 


Gln Val Tyr Thr Tyr Pro His Trp Val Glu Lys Leu Asn Asp Thr Gln 
385                 390                 395                 400 


Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu Cys Lys Ala Thr Gly Lys 
                405                 410                 415     


Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn Gly Val Pro Leu Ser Pro 
            420                 425                 430         


Gln Ser Arg Val Glu Met Val Asn Gly Val Leu Met Ile His Asn Val 
        435                 440                 445             


Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys Leu Ala Glu Asn Lys Tyr 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys Ile Leu Ala Ser Ala Pro 
465                 470                 475                 480 


Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr Ile Ile Val Thr Lys Asp 
                485                 490                 495     


Gln Glu Val Val Ile Glu Cys Lys Pro Gln Gly Ser Pro Lys Pro Thr 
            500                 505                 510         


Ile Ser Trp Lys Lys Gly Asp Arg Ala Val Arg Glu Asn Lys Arg Ile 
        515                 520                 525             


Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile Leu Asn Ala Ser Lys Ser 
    530                 535                 540                 


Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu Asn Val Phe Gly Ser Ala 
545                 550                 555                 560 


Glu Ile Ile Ala Ser Leu Ser Val Lys Glu Pro Thr Arg Ile Glu Leu 
                565                 570                 575     


Thr Pro Lys Arg Thr Glu Leu Thr Val Gly Glu Ser Ile Val Leu Asn 
            580                 585                 590         


Cys Lys Ala Ile His Asp Ala Ser Leu Asp Val Thr Phe Tyr Trp Thr 
        595                 600                 605             


Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu Glu Gly Gly His Phe Glu 
    610                 615                 620                 


Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp Leu Met Ile Arg Asn Ile 
625                 630                 635                 640 


Leu Leu Met His Ala Gly Arg Tyr Gly Cys Arg Val Gln Thr Thr Ala 
                645                 650                 655     


Asp Ser Val Ser Asp Glu Ala Glu Leu Leu Val Arg Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Ile Val Ile Val Glu Glu Ile Thr Glu Ser Thr Ala Thr 
        675                 680                 685             


Leu Ser Trp Ser Pro Ala Ala Asp Asn His Ser Pro Ile Ser Ser Tyr 
    690                 695                 700                 


Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu Gly Trp Gln Thr Val Lys 
705                 710                 715                 720 


Thr Val Pro Glu Ile Ile Thr Gly Asp Met Glu Ser Ala Met Ala Val 
                725                 730                 735     


Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg Val Val Ala Thr Asn 
            740                 745                 750         


Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro Ser Arg Met Ile Arg Thr 
        755                 760                 765             


Asn Glu Ala Val Pro Lys Thr Ala Pro Thr Asn Val Ser Gly Arg Ser 
    770                 775                 780                 


Gly Arg Arg His Glu Leu Val Ile Ala Trp Glu Pro Val Ser Glu Glu 
785                 790                 795                 800 


Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile Val Ala Phe Arg Pro Asn 
                805                 810                 815     


Gly Thr Arg Gly Trp Lys Glu Lys Met Val Thr Ser Ser Glu Ala Ser 
            820                 825                 830         


Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro Pro Leu Thr Pro Phe Glu 
        835                 840                 845             


Val Lys Val Gly Val Tyr Asn Asn Lys Gly Asp Gly Pro Phe Ser Gln 
    850                 855                 860                 


Ile Val Val Ile Cys Ser Ala Glu Gly Glu Pro Ser Ala Ala Pro Thr 
865                 870                 875                 880 


Asp Val Lys Ala Thr Ser Val Ser Val Ser Glu Ile Leu Val Ala Trp 
                885                 890                 895     


Lys His Ile Lys Glu Ser Leu Gly Arg Pro Gln Gly Phe Glu Val Gly 
            900                 905                 910         


Tyr Trp Lys Asp Met Glu Gln Glu Asp Thr Ala Glu Thr Val Lys Thr 
        915                 920                 925             


Arg Gly Asn Glu Ser Phe Val Ile Leu Thr Gly Leu Glu Gly Asn Thr 
    930                 935                 940                 


Leu Tyr His Phe Thr Val Arg Ala Tyr Asn Gly Ala Gly Tyr Gly Pro 
945                 950                 955                 960 


Pro Ser Ser Glu Val Ser Ala Thr Thr Lys Lys Ser Pro Pro Ser Gln 
                965                 970                 975     


Ala Pro Ser Asn Leu Arg Trp Glu Gln Gln Gly Ser Gln Val Ser Leu 
            980                 985                 990         


Gly Trp Glu Pro Val Ile Pro Leu  Ala Asn Glu Ser Glu  Val Val Gly 
        995                 1000                 1005             


Tyr Lys  Val Phe Tyr Arg Gln  Glu Gly His Ser Asn  Ser Gln Val 
    1010                 1015                 1020             


Ile Glu  Thr Gln Lys Leu Gln  Ala Val Val Pro Leu  Pro Asp Ala 
    1025                 1030                 1035             


Gly Val  Tyr Ile Ile Glu Val  Arg Ala Tyr Ser Glu  Gly Gly Asp 
    1040                 1045                 1050             


Gly Thr  Ala Ser Ser Gln Ile  Arg Val Pro Ser Tyr  Ser Gly Gly 
    1055                 1060                 1065             


Lys Ile  Thr Ser Ala Gln Ser  Thr Leu His Ser Leu  Ser Thr Ser 
    1070                 1075                 1080             


Ser Ser  Ser Val Thr Leu Leu  Leu Ala Leu Met Ile  Pro Ser Thr 
    1085                 1090                 1095             


Ser Trp  
    1100 


<210>  2864
<211>  3942
<212>  DNA
<213>  Homosapiens

<400>  2864
aattcgcctc tgccacaggc tgcaaaggac ccgaggaacc gctctctctg aactgtgctg     60

atgggcagga ggatgggaga caggaattga gagtcacaga ggaaggacag tggagtctgg    120

catcttattg gtgtctttaa aggattgcca tttaatgcca ttcaagatct actaagcatc    180

atttttgcat gactactgca aaaggattac tttacagata ccagttcctt tgtcaagagc    240

atactttgga ccctgttttc agaaagcagg gcactcttta atgaagaaac accagagctg    300

ttaaacacat tgagacacag aagattctag tgactgagga tggcttcctc ttggaaacta    360

atgctgtttc tgtcagtcac catgtgtctt tcagaaagtg tggactatgg gccagttttt    420

gtgcaagaac cagatgatat tatttttcca actgattctg atgaaaagaa ggtagcattg    480

aattgtgaag ttcgtggcaa tccagttccc agttacagat ggcttcgaaa tggaacagaa    540

atagatctgg aaagtgatta tcgctacagt ttgatagatg gcaccttcat tataagcaat    600

ccaagtgaag caaaggattc tggtcattat cagtgtttag caaccaacac tgtggggagt    660

attcttagta gagaagctac actgcagttt gcctatctgg gaaattttag tggccggaca    720

agaagtgcag tctctgtgag ggaaggccag ggtgtcgttc tgatgtgctc tcctccgcca    780

cattcaccag agatcatcta tagctgggta tttaatgagt tcccttcctt tgtggcggaa    840

gacagccggc ggttcatctc ccaggagaca ggcaaccttt atatttctaa agtccaaaca    900

tcagatgttg gcagctatat ttgtctggtg aaaaacacag tgacgaatgc tagagtcctt    960

agtcctccaa cgccactcac tctgcgtaat gatggtgtga tgggagaata tgagccgaaa   1020

attgaggtcc attttccttt cacggttaca gctgctaaag gaacaactgt taagatggaa   1080

tgctttgcac ttggcaaccc cgttccaaca atcacatgga tgaaggttaa tggttatatt   1140

cctagtaagg cacgtctgcg gaaatctcag gcggtgctgg aaataccgaa tgtacagctg   1200

gatgatgcag gcatttatga gtgcagagct gaaaactcac gtggaaaaaa ttcctttcgt   1260

ggacaattac aagtatacac ctacccacac tgggtagaaa aactgaatga tactcagtta   1320

gacagtggga gccctctccg atgggaatgt aaggctactg gaaaacccag acccacgtat   1380

cgttggctga agaatggagt acccctctca cctcagagta gggttgagat ggttaatgga   1440

gtattgatga tccacaatgt gaatcaatca gatgctggaa tgtatcagtg tttggctgaa   1500

aataagtatg gagccattta cgctagtgct gagctgaaga ttctagcttc agctcccact   1560

tttgcactga atcaactgaa gaaaacaata attgttacca aagaccaaga agttgtcata   1620

gagtgcaaac cccaaggctc tccaaaacca accatctctt ggaagaaagg agacagagca   1680

gttagagaaa acaaaagaat agctattctt ccagacggga gtctacggat cctaaatgct   1740

tccaaatcag acgagggaaa gtacgtttgc cgaggggaaa acgtctttgg ttctgctgaa   1800

attatagctt cgctatctgt aaaagaacct acaaggatag aacttactcc taaaagaaca   1860

gaattgacag tgggagaaag cattgtcctt aattgcaaag caattcacga tgctagtttg   1920

gatgtcactt tctactggac tctgaaagga cagcctattg atttcgagga agagggtgga   1980

cattttgaaa gcatcagggc ccaagcatcc tctgcagatt taatgatcag gaacatcctt   2040

ctgatgcatg ctgggagata tggctgcagg gtacagacca cagcagacag tgtgtcagat   2100

gaggcagaac ttcttgttag gggaccccca ggcccacctg ggatagtaat tgttgaggaa   2160

ataaccgaaa gtacggccac actgtcctgg agcccagcag ctgacaacca cagcccaatc   2220

tcctcctaca accttcaagc tcgcagccca ttttccctgg gctggcaaac agtaaagaca   2280

gtcccagaaa tcataacagg ggacatggag tcagccatgg ctgtggacct aaatccctgg   2340

gtggaatatg aatttcgagt ggtagccacc aaccctattg ggacaggaga tccaagcacc   2400

ccatctcgaa tgatccgcac aaatgaagca gttccgaaga cagcacccac caatgtaagc   2460

ggaagaagtg gaagaaggca tgagttagtc attgcctggg agccagtatc tgaagagttt   2520

cagaatgggg aaggcttcgg ctatattgtg gctttcagac ccaatggaac acgtggctgg   2580

aaggaaaaaa tggtgacatc ctctgaagct tccaaattca tttatcgaga tgaaagtgtc   2640

cctcctctta ctccctttga agtgaaagtt ggcgtttata acaataaagg agatgggcct   2700

tttagtcaaa ttgtggtcat ctgttcagct gaaggagaac ccagtgctgc tcccacagat   2760

gtcaaggcga caagtgtgtc tgtgtcagag attcttgttg catggaaaca cattaaagag   2820

agtctaggaa gaccacaggg atttgaggtt ggttactgga aagacatgga acaggaagat   2880

acagcagaaa cagtcaaaac tagagggaat gagtctttcg tcatcctaac aggattagaa   2940

ggaaatacgt tatatcactt cacagtgagg gcttacaatg gagctggata tgggccacct   3000

agcagtgaag tgagtgcaac caccaagaaa tcccctccta gtcaagcacc tagcaacctc   3060

aggtgggagc agcaaggctc tcaggtttct ctgggctggg aacccgtcat accattagcc   3120

aacgaatctg aagttgtggg ttacaaggtt ttttataggc aagagggtca cagcaacagc   3180

caagttattg aaacacagaa acttcaagca gtagtaccac tcccagatgc tggagtctat   3240

attattgaag ttcgagcata tagtgaagga ggagatggaa cagctagttc tcaaattagg   3300

gtaccatcat attcaggtgg aaaaatcaca agtgcacagt cgacccttca ctctctctcc   3360

acatcttcgt catcagtcac cttgctcttg gcattgatga ttccttcaac ttcctggtga   3420

aaactgctga cttaatttgc ttttgtttgc tttagcttgg taacagcggt gaatagagtg   3480

tagtgtaagt ggagaaccag gatcctgaga tgagcttgag ctttaaaaac ttgggactat   3540

acatggtgaa cttacaggag gttagggggg aaatattact tatccatcag gtttctcttt   3600

ggtttttgta aacggagagg acagttctta gtccagtaaa aatatgcaga ttgtatgtaa   3660

tgaatttttg taaacaaagg taatttctgt caaatgtatt ctttactttt ttaatatgtt   3720

gggattttat tttatatctg atgactccga gtgtgtgcca tccatttgtt aagtaactgg   3780

cctttagcag atctgtttca aaaacaaata caaaaatgag aatgaaaagt ttgcttaaga   3840

ctaagtccag tgtttttcat tttccctttg gctgaatatt tcaattgaca aaccagcagg   3900

acatatgaaa aatgcttcag tgatgtggtc cattataaga ta                      3942


<210>  2865
<211>  1026
<212>  PRT
<213>  Homosapiens

<400>  2865

Met Ala Ser Ser Trp Lys Leu Met Leu Phe Leu Ser Val Thr Met Cys 
1               5                   10                  15      


Leu Ser Glu Ser Val Asp Tyr Gly Pro Val Phe Val Gln Glu Pro Asp 
            20                  25                  30          


Asp Ile Ile Phe Pro Thr Asp Ser Asp Glu Lys Lys Val Ala Leu Asn 
        35                  40                  45              


Cys Glu Val Arg Gly Asn Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn 
    50                  55                  60                  


Gly Thr Glu Ile Asp Leu Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp 
65                  70                  75                  80  


Gly Thr Phe Ile Ile Ser Asn Pro Ser Glu Ala Lys Asp Ser Gly His 
                85                  90                  95      


Tyr Gln Cys Leu Ala Thr Asn Thr Val Gly Ser Ile Leu Ser Arg Glu 
            100                 105                 110         


Ala Thr Leu Gln Phe Ala Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg 
        115                 120                 125             


Ser Ala Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Met Cys Ser 
    130                 135                 140                 


Pro Pro Pro His Ser Pro Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu 
145                 150                 155                 160 


Phe Pro Ser Phe Val Ala Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu 
                165                 170                 175     


Thr Gly Asn Leu Tyr Ile Ser Lys Val Gln Thr Ser Asp Val Gly Ser 
            180                 185                 190         


Tyr Ile Cys Leu Val Lys Asn Thr Val Thr Asn Ala Arg Val Leu Ser 
        195                 200                 205             


Pro Pro Thr Pro Leu Thr Leu Arg Asn Asp Gly Val Met Gly Glu Tyr 
    210                 215                 220                 


Glu Pro Lys Ile Glu Val His Phe Pro Phe Thr Val Thr Ala Ala Lys 
225                 230                 235                 240 


Gly Thr Thr Val Lys Met Glu Cys Phe Ala Leu Gly Asn Pro Val Pro 
                245                 250                 255     


Thr Ile Thr Trp Met Lys Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg 
            260                 265                 270         


Leu Arg Lys Ser Gln Ala Val Leu Glu Ile Pro Asn Val Gln Leu Asp 
        275                 280                 285             


Asp Ala Gly Ile Tyr Glu Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn 
    290                 295                 300                 


Ser Phe Arg Gly Gln Leu Gln Val Tyr Thr Tyr Pro His Trp Val Glu 
305                 310                 315                 320 


Lys Leu Asn Asp Thr Gln Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu 
                325                 330                 335     


Cys Lys Ala Thr Gly Lys Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn 
            340                 345                 350         


Gly Val Pro Leu Ser Pro Gln Ser Arg Val Glu Met Val Asn Gly Val 
        355                 360                 365             


Leu Met Ile His Asn Val Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys 
    370                 375                 380                 


Leu Ala Glu Asn Lys Tyr Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys 
385                 390                 395                 400 


Ile Leu Ala Ser Ala Pro Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr 
                405                 410                 415     


Ile Ile Val Thr Lys Asp Gln Glu Val Val Ile Glu Cys Lys Pro Gln 
            420                 425                 430         


Gly Ser Pro Lys Pro Thr Ile Ser Trp Lys Lys Gly Asp Arg Ala Val 
        435                 440                 445             


Arg Glu Asn Lys Arg Ile Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile 
    450                 455                 460                 


Leu Asn Ala Ser Lys Ser Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu 
465                 470                 475                 480 


Asn Val Phe Gly Ser Ala Glu Ile Ile Ala Ser Leu Ser Val Lys Glu 
                485                 490                 495     


Pro Thr Arg Ile Glu Leu Thr Pro Lys Arg Thr Glu Leu Thr Val Gly 
            500                 505                 510         


Glu Ser Ile Val Leu Asn Cys Lys Ala Ile His Asp Ala Ser Leu Asp 
        515                 520                 525             


Val Thr Phe Tyr Trp Thr Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu 
    530                 535                 540                 


Glu Gly Gly His Phe Glu Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp 
545                 550                 555                 560 


Leu Met Ile Arg Asn Ile Leu Leu Met His Ala Gly Arg Tyr Gly Cys 
                565                 570                 575     


Arg Val Gln Thr Thr Ala Asp Ser Val Ser Asp Glu Ala Glu Leu Leu 
            580                 585                 590         


Val Arg Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Val Glu Glu Ile 
        595                 600                 605             


Thr Glu Ser Thr Ala Thr Leu Ser Trp Ser Pro Ala Ala Asp Asn His 
    610                 615                 620                 


Ser Pro Ile Ser Ser Tyr Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu 
625                 630                 635                 640 


Gly Trp Gln Thr Val Lys Thr Val Pro Glu Ile Ile Thr Gly Asp Met 
                645                 650                 655     


Glu Ser Ala Met Ala Val Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe 
            660                 665                 670         


Arg Val Val Ala Thr Asn Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro 
        675                 680                 685             


Ser Arg Met Ile Arg Thr Asn Glu Ala Val Pro Lys Thr Ala Pro Thr 
    690                 695                 700                 


Asn Val Ser Gly Arg Ser Gly Arg Arg His Glu Leu Val Ile Ala Trp 
705                 710                 715                 720 


Glu Pro Val Ser Glu Glu Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile 
                725                 730                 735     


Val Ala Phe Arg Pro Asn Gly Thr Arg Gly Trp Lys Glu Lys Met Val 
            740                 745                 750         


Thr Ser Ser Glu Ala Ser Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro 
        755                 760                 765             


Pro Leu Thr Pro Phe Glu Val Lys Val Gly Val Tyr Asn Asn Lys Gly 
    770                 775                 780                 


Asp Gly Pro Phe Ser Gln Ile Val Val Ile Cys Ser Ala Glu Gly Glu 
785                 790                 795                 800 


Pro Ser Ala Ala Pro Thr Asp Val Lys Ala Thr Ser Val Ser Val Ser 
                805                 810                 815     


Glu Ile Leu Val Ala Trp Lys His Ile Lys Glu Ser Leu Gly Arg Pro 
            820                 825                 830         


Gln Gly Phe Glu Val Gly Tyr Trp Lys Asp Met Glu Gln Glu Asp Thr 
        835                 840                 845             


Ala Glu Thr Val Lys Thr Arg Gly Asn Glu Ser Phe Val Ile Leu Thr 
    850                 855                 860                 


Gly Leu Glu Gly Asn Thr Leu Tyr His Phe Thr Val Arg Ala Tyr Asn 
865                 870                 875                 880 


Gly Ala Gly Tyr Gly Pro Pro Ser Ser Glu Val Ser Ala Thr Thr Lys 
                885                 890                 895     


Lys Ser Pro Pro Ser Gln Ala Pro Ser Asn Leu Arg Trp Glu Gln Gln 
            900                 905                 910         


Gly Ser Gln Val Ser Leu Gly Trp Glu Pro Val Ile Pro Leu Ala Asn 
        915                 920                 925             


Glu Ser Glu Val Val Gly Tyr Lys Val Phe Tyr Arg Gln Glu Gly His 
    930                 935                 940                 


Ser Asn Ser Gln Val Ile Glu Thr Gln Lys Leu Gln Ala Val Val Pro 
945                 950                 955                 960 


Leu Pro Asp Ala Gly Val Tyr Ile Ile Glu Val Arg Ala Tyr Ser Glu 
                965                 970                 975     


Gly Gly Asp Gly Thr Ala Ser Ser Gln Ile Arg Val Pro Ser Tyr Ser 
            980                 985                 990         


Gly Gly Lys Ile Thr Ser Ala Gln  Ser Thr Leu His Ser  Leu Ser Thr 
        995                 1000                 1005             


Ser Ser  Ser Ser Val Thr Leu  Leu Leu Ala Leu Met  Ile Pro Ser 
    1010                 1015                 1020             


Thr Ser  Trp 
    1025     


<210>  2866
<211>  2920
<212>  DNA
<213>  Homosapiens

<400>  2866
gagtcatctg atagctcatc aagctctgaa gatgagtggg ttgaggctgt tccatcccag     60

actcctgaca aggaaaaagc ctggaaagtg aaagatgaaa agtcaggaaa agatgacacc    120

caaattatca agagggatga gtggatgact gttgatttta tgtctgttaa aactgtgtca    180

tcatcatcac tcaaagctga aaaggaaact atgaggaaaa tagagcaaga gaaaaaccaa    240

gcgcttgaac agtccaaact gatggaaaga gaattgaatc cgtactggaa ggatggtggg    300

acaggtcttc cacctgaaga ctgtagtgtg tcatcgatta ctaaagtttc agtggtagaa    360

gatggtggat taagctggct aaggaaatct tatctaagaa tgaaggaaca agctgagaaa    420

caaagtagaa actttgagga cattgtagcc gaaagatatg ggtcaatgga aatatttcag    480

tcaaaattag aagatgctga aaaagctgca tccacgaaag aagattatag acgggaacgg    540

tggaggaaac ccacatattc agataaagca caaaattgtc aagaaagtag agaatcagac    600

ttagtaaaat atggtaacag ttcaagggat agatatgcta caacagatac tgcaaaaaat    660

agcaataatg aaaaatttat tggtgatgaa aaagataaga gacctgggtc tttagaaacg    720

tgtagaagag aatctaaccc aaggcaaaat caagagtttt cttttggcaa tttgagagct    780

aaattcttga gaccctctga tgatgaagaa ctgtcatttc acagcaaggg cagaaaattt    840

gaaccactta gttcatcttc agcattggta gctcagggct ctttgtgtag tggttttaga    900

aaacccacca agaacagtga agaaagatta acatcatgga gtcgctctga tgggagagga    960

gacaagaaac attcaaatca aaagccatcg gaaaccagta ctgatgaaca ccaacatgtt   1020

ccagaagacc caagagaaaa atcacaagat gaagtcttga gagatgaccc tccaaaaaaa   1080

gaacatctac gggatacaaa gtctacattt gctggcagtc cagagcgtga gtccattcac   1140

atcctgagtg ttgatgagaa gaacaagttg ggagccaaga ttatcaaagc agagatgatg   1200

gggaatatgg aattagctga acaacttaaa gttcaacttg aaaaggcaaa taaattcaaa   1260

gaaactataa cacagatacc aaaaaaatct ggggtagaga atgaagacca gcaagaagta   1320

atccttgtca gaacagatca gtctggaaga gtatggcctg tgaacacacc cggaaagtct   1380

ctggaatcac aaggaggaag aagaaagaga cagatggttt caacccatga ggaaagagaa   1440

agggtcagat actttcatga tgatgataat ctaagcctaa atgatttagt caaaaatgaa   1500

aagatgggaa cagcagaaaa tcaaaacaag ctctttatga gaatggcatc taagtttatg   1560

ggaaaaacag atggagacta ttacaccctg gatgacatgt ttgtctccaa agcagctgag   1620

agagaacgtc ttggtgaaga ggaagagaac caaaggaaaa aagctattgc tgagcatcgg   1680

agtcttgctg cacaaatgga aaaatgtctg tattgttttg acagctctca atttcccaag   1740

catcttattg ttgcaatagg tgttaaggtt tatttatgtt tacccaacgt acggtctctt   1800

actgaggggc actgcctgat agtccctttg cagcaccata gagcagctac tttgttggat   1860

gaagacatct gggaggagat ccagatgttc agaaaatcat tggtaaagat gtttgaagat   1920

aaaggattag actgcatttt tttggaaact aatatgagca tgaagaaaca gtatcacatg   1980

gtttatgaat gtattcctct tcccaaggaa gtgggtgaca tggctcccat ctattttaag   2040

aaagccataa tggaatctga tgaagagtgg tccatgaaca agaagttgat agatctctct   2100

tcaaaagata tcagaaagtc tgtacccaga gggttacctt acttctctgt ggattttggc   2160

cttcacggag ggtttgccca tgtcattgaa gatcagcaca aattccctca ttactttgga   2220

aaggaaatca taggtgggat gctggatata gaaccaagac tttggaggaa aggcatccga   2280

gaaagctttg aggatcagag gaaaaaagca ctgcagtttg ctcagtggtg gaaaccatat   2340

gacttcacca aaagtaaaaa ctattgaggt gtaccttcca ttttaaaatt tttcttcaga   2400

tcccgttcag ttttatttcc attgcatcta atgaagcaac tgaccctcag gtcacaggca   2460

gagagaatca cagcagcaga ctgctctggg tcagtgacaa ctgtacatca ggagattgtg   2520

ttgttttctt cttcacctgc tcctatctat ggacttcatt ttagtcacca tggagtaaaa   2580

acatatattc gatgatctgc tcacattcct gctctctacc tacttcttgg tattccgaat   2640

tgttcagtta atttagagaa ggccttttct gaagggatat ctagaaagca taggaaatcc   2700

ttggttcaga gggaagtggg tctgcttcat ggttgttaag tctactgtct ggcttctttt   2760

gcatttttaa aaataagacg atttaatttt aatttcatag gattttatag aaaagctctt   2820

aattttctac tagcagtata tagtatcact tctattcttt ttgttaaagg aaaaggaaat   2880

gtccccaaag tattaaagaa ttaaatgata ctgaaaattt                         2920


<210>  2867
<211>  740
<212>  PRT
<213>  Homosapiens

<400>  2867

Met Thr Val Asp Phe Met Ser Val Lys Thr Val Ser Ser Ser Ser Leu 
1               5                   10                  15      


Lys Ala Glu Lys Glu Thr Met Arg Lys Ile Glu Gln Glu Lys Asn Gln 
            20                  25                  30          


Ala Leu Glu Gln Ser Lys Leu Met Glu Arg Glu Leu Asn Pro Tyr Trp 
        35                  40                  45              


Lys Asp Gly Gly Thr Gly Leu Pro Pro Glu Asp Cys Ser Val Ser Ser 
    50                  55                  60                  


Ile Thr Lys Val Ser Val Val Glu Asp Gly Gly Leu Ser Trp Leu Arg 
65                  70                  75                  80  


Lys Ser Tyr Leu Arg Met Lys Glu Gln Ala Glu Lys Gln Ser Arg Asn 
                85                  90                  95      


Phe Glu Asp Ile Val Ala Glu Arg Tyr Gly Ser Met Glu Ile Phe Gln 
            100                 105                 110         


Ser Lys Leu Glu Asp Ala Glu Lys Ala Ala Ser Thr Lys Glu Asp Tyr 
        115                 120                 125             


Arg Arg Glu Arg Trp Arg Lys Pro Thr Tyr Ser Asp Lys Ala Gln Asn 
    130                 135                 140                 


Cys Gln Glu Ser Arg Glu Ser Asp Leu Val Lys Tyr Gly Asn Ser Ser 
145                 150                 155                 160 


Arg Asp Arg Tyr Ala Thr Thr Asp Thr Ala Lys Asn Ser Asn Asn Glu 
                165                 170                 175     


Lys Phe Ile Gly Asp Glu Lys Asp Lys Arg Pro Gly Ser Leu Glu Thr 
            180                 185                 190         


Cys Arg Arg Glu Ser Asn Pro Arg Gln Asn Gln Glu Phe Ser Phe Gly 
        195                 200                 205             


Asn Leu Arg Ala Lys Phe Leu Arg Pro Ser Asp Asp Glu Glu Leu Ser 
    210                 215                 220                 


Phe His Ser Lys Gly Arg Lys Phe Glu Pro Leu Ser Ser Ser Ser Ala 
225                 230                 235                 240 


Leu Val Ala Gln Gly Ser Leu Cys Ser Gly Phe Arg Lys Pro Thr Lys 
                245                 250                 255     


Asn Ser Glu Glu Arg Leu Thr Ser Trp Ser Arg Ser Asp Gly Arg Gly 
            260                 265                 270         


Asp Lys Lys His Ser Asn Gln Lys Pro Ser Glu Thr Ser Thr Asp Glu 
        275                 280                 285             


His Gln His Val Pro Glu Asp Pro Arg Glu Lys Ser Gln Asp Glu Val 
    290                 295                 300                 


Leu Arg Asp Asp Pro Pro Lys Lys Glu His Leu Arg Asp Thr Lys Ser 
305                 310                 315                 320 


Thr Phe Ala Gly Ser Pro Glu Arg Glu Ser Ile His Ile Leu Ser Val 
                325                 330                 335     


Asp Glu Lys Asn Lys Leu Gly Ala Lys Ile Ile Lys Ala Glu Met Met 
            340                 345                 350         


Gly Asn Met Glu Leu Ala Glu Gln Leu Lys Val Gln Leu Glu Lys Ala 
        355                 360                 365             


Asn Lys Phe Lys Glu Thr Ile Thr Gln Ile Pro Lys Lys Ser Gly Val 
    370                 375                 380                 


Glu Asn Glu Asp Gln Gln Glu Val Ile Leu Val Arg Thr Asp Gln Ser 
385                 390                 395                 400 


Gly Arg Val Trp Pro Val Asn Thr Pro Gly Lys Ser Leu Glu Ser Gln 
                405                 410                 415     


Gly Gly Arg Arg Lys Arg Gln Met Val Ser Thr His Glu Glu Arg Glu 
            420                 425                 430         


Arg Val Arg Tyr Phe His Asp Asp Asp Asn Leu Ser Leu Asn Asp Leu 
        435                 440                 445             


Val Lys Asn Glu Lys Met Gly Thr Ala Glu Asn Gln Asn Lys Leu Phe 
    450                 455                 460                 


Met Arg Met Ala Ser Lys Phe Met Gly Lys Thr Asp Gly Asp Tyr Tyr 
465                 470                 475                 480 


Thr Leu Asp Asp Met Phe Val Ser Lys Ala Ala Glu Arg Glu Arg Leu 
                485                 490                 495     


Gly Glu Glu Glu Glu Asn Gln Arg Lys Lys Ala Ile Ala Glu His Arg 
            500                 505                 510         


Ser Leu Ala Ala Gln Met Glu Lys Cys Leu Tyr Cys Phe Asp Ser Ser 
        515                 520                 525             


Gln Phe Pro Lys His Leu Ile Val Ala Ile Gly Val Lys Val Tyr Leu 
    530                 535                 540                 


Cys Leu Pro Asn Val Arg Ser Leu Thr Glu Gly His Cys Leu Ile Val 
545                 550                 555                 560 


Pro Leu Gln His His Arg Ala Ala Thr Leu Leu Asp Glu Asp Ile Trp 
                565                 570                 575     


Glu Glu Ile Gln Met Phe Arg Lys Ser Leu Val Lys Met Phe Glu Asp 
            580                 585                 590         


Lys Gly Leu Asp Cys Ile Phe Leu Glu Thr Asn Met Ser Met Lys Lys 
        595                 600                 605             


Gln Tyr His Met Val Tyr Glu Cys Ile Pro Leu Pro Lys Glu Val Gly 
    610                 615                 620                 


Asp Met Ala Pro Ile Tyr Phe Lys Lys Ala Ile Met Glu Ser Asp Glu 
625                 630                 635                 640 


Glu Trp Ser Met Asn Lys Lys Leu Ile Asp Leu Ser Ser Lys Asp Ile 
                645                 650                 655     


Arg Lys Ser Val Pro Arg Gly Leu Pro Tyr Phe Ser Val Asp Phe Gly 
            660                 665                 670         


Leu His Gly Gly Phe Ala His Val Ile Glu Asp Gln His Lys Phe Pro 
        675                 680                 685             


His Tyr Phe Gly Lys Glu Ile Ile Gly Gly Met Leu Asp Ile Glu Pro 
    690                 695                 700                 


Arg Leu Trp Arg Lys Gly Ile Arg Glu Ser Phe Glu Asp Gln Arg Lys 
705                 710                 715                 720 


Lys Ala Leu Gln Phe Ala Gln Trp Trp Lys Pro Tyr Asp Phe Thr Lys 
                725                 730                 735     


Ser Lys Asn Tyr 
            740 


<210>  2868
<211>  1685
<212>  DNA
<213>  Homosapiens

<400>  2868
ggcgtgcaag tatccgctgc ggtgttctgg tgctagagtg gagaggctgg caaagaagaa     60

ggcacacgca tggtgagaat ccggcctgag ccgaagcgga gtttgctatg gacagcaacc    120

atcaaagtaa ttacaaactc agtaaaactg agaagaagtt cttaaggaaa cagattaaag    180

ccaagcatac tttgctgaga catgaaggca ttgagacagt atcctatgcc actcagagcc    240

tggttgttgc caatggtggt ttgggtaatg gtgtgagtcg gaaccagctg ctcccggttt    300

tagagaaatg tggactggtg gatgctctct taatgccacc taacaagccg tactcatttg    360

caagatacag aactacagaa gaatctaaga gagcctatgt taccctcaat ggaaaagaag    420

tagtggatga tttaggacaa aagatcactc tgtatttgaa ttttgtggaa aaagtgcagt    480

ggaaggagtt gaggcctcaa gccttaccac caggactcat ggtagtagaa gaaataattt    540

cttctgagga ggagaaaatg cttttggaaa gtgttgattg gacagaagat acagacaatc    600

aaaactctca aaaatcctta aaacacagaa gagtaaagca ttttggttat gagttccact    660

atgagaacaa caatgtagat aaagataagc cattatctgg gggtcttcct gacatttgtg    720

aaagcttttt ggagaaatgg ttgaggaaag gttacattaa acataaacct gatcaaatga    780

ccataaatca gtatgaacct gggcaagatt gtcatggatt ttaagcaccc agatggcatt    840

gcagtgccag ttatgttgcc tcgtcggagt ttgctggtga tgacaggaga atctagatac    900

ctttggaccc atggaatcac gtgcagaaaa tttgatactg ttcaagcatc tgagagtctt    960

aaaagtggaa ttatcaccag tgatgttgga gacttaactt taagcaagag gggactacga   1020

acatcattta catttaggaa agtgaggcaa acaccttgta actgtagagc gtagagtggc   1080

agctctccaa gaaattgttc gactcctgag accaggtggg aaggcactca tttatgtctg   1140

ggcaatggaa caagaatata ataagcagaa gtccaagtat cttagaggaa acagaaatag   1200

ccaaggaaag aaagaggaga tgaacagtga tacctcagtg cagaggtcac ttgtggagca   1260

aatgcgtgac atgggcagtc gagactcggc atcttctgtc ccccgcatta atgactctca   1320

ggaaggagga tgtaattcaa ggcaagtttc taattccaag ctgcctgttc atgttaacag   1380

gacttctttt tattctcaag atgtactggt tccctggcac cttaagggaa atcctgataa   1440

aggcaaacct gttgagccat ttggtcccat aggatcccag gacccaagtc ctgtgtttca   1500

tcgttactac catgtgttcc gtgagggaga actggaaggt gcctgcagga ctgtgagtga   1560

tgtcagaatt ctgcaaagct actacgatca aggaaactgg tgtgtgattc ttcaaaaggc   1620

ctgattattt acctgaacac atcatatata aagaagaaat gctcacttaa aaaaaaaaaa   1680

aaaaa                                                               1685


<210>  2869
<211>  238
<212>  PRT
<213>  Homosapiens

<400>  2869

Met Asp Ser Asn His Gln Ser Asn Tyr Lys Leu Ser Lys Thr Glu Lys 
1               5                   10                  15      


Lys Phe Leu Arg Lys Gln Ile Lys Ala Lys His Thr Leu Leu Arg His 
            20                  25                  30          


Glu Gly Ile Glu Thr Val Ser Tyr Ala Thr Gln Ser Leu Val Val Ala 
        35                  40                  45              


Asn Gly Gly Leu Gly Asn Gly Val Ser Arg Asn Gln Leu Leu Pro Val 
    50                  55                  60                  


Leu Glu Lys Cys Gly Leu Val Asp Ala Leu Leu Met Pro Pro Asn Lys 
65                  70                  75                  80  


Pro Tyr Ser Phe Ala Arg Tyr Arg Thr Thr Glu Glu Ser Lys Arg Ala 
                85                  90                  95      


Tyr Val Thr Leu Asn Gly Lys Glu Val Val Asp Asp Leu Gly Gln Lys 
            100                 105                 110         


Ile Thr Leu Tyr Leu Asn Phe Val Glu Lys Val Gln Trp Lys Glu Leu 
        115                 120                 125             


Arg Pro Gln Ala Leu Pro Pro Gly Leu Met Val Val Glu Glu Ile Ile 
    130                 135                 140                 


Ser Ser Glu Glu Glu Lys Met Leu Leu Glu Ser Val Asp Trp Thr Glu 
145                 150                 155                 160 


Asp Thr Asp Asn Gln Asn Ser Gln Lys Ser Leu Lys His Arg Arg Val 
                165                 170                 175     


Lys His Phe Gly Tyr Glu Phe His Tyr Glu Asn Asn Asn Val Asp Lys 
            180                 185                 190         


Asp Lys Pro Leu Ser Gly Gly Leu Pro Asp Ile Cys Glu Ser Phe Leu 
        195                 200                 205             


Glu Lys Trp Leu Arg Lys Gly Tyr Ile Lys His Lys Pro Asp Gln Met 
    210                 215                 220                 


Thr Ile Asn Gln Tyr Glu Pro Gly Gln Asp Cys His Gly Phe 
225                 230                 235             


<210>  2870
<211>  2741
<212>  DNA
<213>  Homosapiens

<400>  2870
ggggatgaag accacgccgc cgcgcgccgg gagctgctga gcctaccgcc gccagagtcc     60

agttgacact tactttgaca aaggcaaatt tggaagcaat tacttgagga cagttcatat    120

agcatctgga cagtcaacac gggcaccatg aagcacttcc tgagaatgtt gatccaggta    180

tgcctgtatt tttactgtaa atttctgtgg cgctgcctga aatttgtaat gaggaagcta    240

actggaagat gtgaactaca acggatctgt tataatacca agccgggagc ttctagaacc    300

atgaaaatcg aaacatcact gagggattct aaaagtaagc tgttgcagac ttctgtgagt    360

gttcaccccg acgctattga aaaaactata gaagatatca tggaactgaa aaaaattaat    420

cctgacgtaa atccacagct gggaatctct cttcaggctt gccttctgca aatcgttggg    480

tacaggaacc ttattgcaga tgtggaaaaa ctgcgtagag aggcctatga ttctgataat    540

ccccaacatg aagaaatgct tttgaagtta tggaaattct tgaagcccaa tactccactg    600

gaatctcgga tttctaagca gtggtgtgaa attggtttcc aaggtgatga tcctaaaaca    660

gactttcgag gaatgggact tctgggactg tacaatttgc agtatttcgc ggaaagggat    720

gccacagcag ctcagcaggt cctgtctgac tctcttcatc cgaaatgcag ggatatcact    780

aaagaagaaa taagcaaatt cagcaaagca gaatgggaga agaaaaggat ggataaggca    840

attgggtact catttgcaat tgtgggcatc aatataactg acctggcata taatctactg    900

gtcagcggag ctctaaaaac ccatttctac aatatcgccc cagaagctcc aacattgtct    960

cactttcagc aaacattctg ctatttgatg catgaatttc ataagttttg gatcgaagag   1020

gaccccatgg acataatgga atttaatcgt gtgagggaga aattccgcaa gaggatcatc   1080

aaacagctgc agaacccaga catggcgctg tgcccacatt ttgctgcctc ggaaggttta   1140

atcaacatgt agttgcccac gccggtttta atggataccc tggaacactg cctcattgtc   1200

ttgttagatc tctgcttagg tcgcagctca cgcattgaat gcacacagtg attgtatgca   1260

tgccttttgg tacagtgttt tcatctcttg gtcataattc cgagatcccc agagaccact   1320

gtttctggag tatctgtcat ccagtgactg ctcatattgt ggcattatgc agtgttacat   1380

cttgccttga tacccaggta tggagagagt tttctatttt tttagacttt ttttcctctc   1440

cctcgtaatt cagcattaaa gaattgtatt tctctagctg tattttgtat gtaagaggtt   1500

tagctgaatc tcattctgtg aaagcctttt aatttattga aatgtttcat gactactgct   1560

gctagctctt caagccaggt tcatgcttgg acctcattct gataaagtat aagactttaa   1620

aataatacaa aacagggccg ggcgcagtgg ctcacacctg taatcccagc actttgggga   1680

gctgaggcgg gcggatcacg aggtcaagag atcgagacca tcctggccaa catggtgaaa   1740

ccccgtctct actaaaaata acaaaaatta gctgggcgtg gtggtgggtg cctgtaatcc   1800

cagctactcg ggaggctgag gcaggagaat cgcttgaacc cgggaggtgg aggttgcagt   1860

gagccgagat cataccactg cactccagcc tggcgacaga gcaagactcc atctcaaaaa   1920

taattaaata aataaataaa taaataaata aataaataaa taaaatagta cagacagaca   1980

catgataagc caaactgttc ctgcaaacat agctatgctt catgaggctt acaagaagta   2040

actttaggta ggagctgttt ttgtttgaag tactgcagaa ttatattgta acttcccctc   2100

accccagttg caattgtgtc atagtcatct gtatatcaaa ctattttatt cccataactt   2160

cattggcttg gatgcctaag tgtatgatgc ttgaagcctc agaaaagaaa taagcatatt   2220

tcaaaagctg caaaaggttt ttcactgcct gcctcttgcg gaactgggtt acaccctggc   2280

actgttctga tccaagcata tttgcttggg gaactaagtg ctgactagtt tgttttctat   2340

gtcaaggggc aatattaaaa aacaatttgc aagaaaatgt gtttcaagag agcaacctaa   2400

gctaagtcac tctgcgatat ttcttgaaaa taacgacctt gtcttgtatc agtggaagaa   2460

gtaagttgct tagaaaggga aaagtcaaat tgttccagaa ctgctaaaaa tcattttaaa   2520

aaccatgatt tagtttggaa ttatgattgt agtctgttga atagtattta ccatggcatt   2580

tcatacccat ggtattttat accttctgac tatcaatttt agtattatta gatgtttgtg   2640

taaccacttg cttatttaaa tgaattttga gtactgccta attgtcagtt atatgaataa   2700

attacatgtc attctactgt aacgtaaaaa aaaaaaaaaa a                       2741


<210>  2871
<211>  283
<212>  PRT
<213>  Homosapiens

<400>  2871

Met Lys Ile Glu Thr Ser Leu Arg Asp Ser Lys Ser Lys Leu Leu Gln 
1               5                   10                  15      


Thr Ser Val Ser Val His Pro Asp Ala Ile Glu Lys Thr Ile Glu Asp 
            20                  25                  30          


Ile Met Glu Leu Lys Lys Ile Asn Pro Asp Val Asn Pro Gln Leu Gly 
        35                  40                  45              


Ile Ser Leu Gln Ala Cys Leu Leu Gln Ile Val Gly Tyr Arg Asn Leu 
    50                  55                  60                  


Ile Ala Asp Val Glu Lys Leu Arg Arg Glu Ala Tyr Asp Ser Asp Asn 
65                  70                  75                  80  


Pro Gln His Glu Glu Met Leu Leu Lys Leu Trp Lys Phe Leu Lys Pro 
                85                  90                  95      


Asn Thr Pro Leu Glu Ser Arg Ile Ser Lys Gln Trp Cys Glu Ile Gly 
            100                 105                 110         


Phe Gln Gly Asp Asp Pro Lys Thr Asp Phe Arg Gly Met Gly Leu Leu 
        115                 120                 125             


Gly Leu Tyr Asn Leu Gln Tyr Phe Ala Glu Arg Asp Ala Thr Ala Ala 
    130                 135                 140                 


Gln Gln Val Leu Ser Asp Ser Leu His Pro Lys Cys Arg Asp Ile Thr 
145                 150                 155                 160 


Lys Glu Glu Ile Ser Lys Phe Ser Lys Ala Glu Trp Glu Lys Lys Arg 
                165                 170                 175     


Met Asp Lys Ala Ile Gly Tyr Ser Phe Ala Ile Val Gly Ile Asn Ile 
            180                 185                 190         


Thr Asp Leu Ala Tyr Asn Leu Leu Val Ser Gly Ala Leu Lys Thr His 
        195                 200                 205             


Phe Tyr Asn Ile Ala Pro Glu Ala Pro Thr Leu Ser His Phe Gln Gln 
    210                 215                 220                 


Thr Phe Cys Tyr Leu Met His Glu Phe His Lys Phe Trp Ile Glu Glu 
225                 230                 235                 240 


Asp Pro Met Asp Ile Met Glu Phe Asn Arg Val Arg Glu Lys Phe Arg 
                245                 250                 255     


Lys Arg Ile Ile Lys Gln Leu Gln Asn Pro Asp Met Ala Leu Cys Pro 
            260                 265                 270         


His Phe Ala Ala Ser Glu Gly Leu Ile Asn Met 
        275                 280             


<210>  2872
<211>  716
<212>  DNA
<213>  Homosapiens

<400>  2872
agacagcctg ggagggagaa ggagttggag ctcaagttgg agacagcgag gagaaacctg     60

ccatagccag ggtgtgtctt tgatcctctt caggaggtga ggacaagcca gaggtccttg    120

gtgtgccctc agaaatctgc ctgcagttct caccaagccg ctgtgaaaat ggggataaac    180

acccgggagc tgtttctcaa cttcactatt gtcttgatta cggttattct tatgtggctc    240

cttgtgaggt cctatcagta ctgagaggcc atgccatggt cctgggattg actgagatgc    300

tccggagctg cctgctctat gccctgagac cccactgctg tcattgtcac aggatgccat    360

tctccatccg agggcacctg tgacctgcac tcacaatatc tgctatgctg tagtgctagg    420

attgattatg tgttctccaa agatgctgct cccaagggct gccaagtgtt tgccagggaa    480

cggtagattt attccccaac tcttaactga aaatgtgtta gacaagccac aaagttaaaa    540

ttaaactgga ttcatgatga tgtaggattg ttacaagccc ctgatctgtc tcaccacaca    600

tcccttcaac ccacacggtc tgcaaccaaa ctctaattca acctgccaga aggaatgtta    660

gaggaagtct ttgtcagccc ttatagctat catgtgaata aagttaagtc aacttc        716


<210>  2873
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  2873

Met Gly Ile Asn Thr Arg Glu Leu Phe Leu Asn Phe Thr Ile Val Leu 
1               5                   10                  15      


Ile Thr Val Ile Leu Met Trp Leu Leu Val Arg Ser Tyr Gln Tyr 
            20                  25                  30      


<210>  2874
<211>  2960
<212>  DNA
<213>  Homosapiens

<400>  2874
gaattcgagg atccgggtac catggcgcgt gaacgcagct cggctgccgc tggcaggaaa     60

caattctgca aaaataatca tactcagcct ggcaattgtc tgcccctagg tctgtcgctc    120

agccgccgtc cacactcgct gcaggggggg gggcacagaa tttaccgcgg caagaacatc    180

cctcccagcc agcagattac aatgctgcaa actaaggatc tcatctggac tttgtttttc    240

ctgggaactg cagtttctct gcaggtggat attgttccca gccaggggga gatcagcgtt    300

ggagagtcca aattcttctt atgccaagtg gcaggagatg ccaaagataa agacatctcc    360

tggttctccc ccaatggaga aaagctcacc ccaaaccagc agcggatctc agtggtgtgg    420

aatgatgatt cctcctccac cctcaccatc tataacgcca acatcgacga cgccggcatt    480

tacaagtgtg tggttacagg cgaggatggc agtgagtcag aggccaccgt caacgtgaag    540

atctttcaga agctcatgtt caagaatgcg ccaaccccac aggagttccg ggagggggaa    600

gatgccgtga ttgtgtgtga tgtggtcagc tccctcccac caaccatcat ctggaaacac    660

aaaggccgag atgtcatcct gaaaaaagat gtccgattca tagtcctgtc caacaactac    720

ctgcagatcc ggggcatcaa gaaaacagat gagggcactt atcgctgtga gggcagaatc    780

ctggcacggg gggagatcaa cttcaaggac attcaggtca ttgtgaatgt gccacctacc    840

atccaggcca ggcagaatat tgtgaatgcc accgccaacc tcggccagtc cgtcaccctg    900

gtgtgcgatg ccgaaggctt cccagagccc accatgagct ggacaaagga tggggaacag    960

atagagcaag aggaagacga tgagaagtac atcttcagcg acgatagttc ccagctgacc   1020

atcaaaaagg tggataagaa cgacgaggct gagtacatct gcattgctga gaacaaggct   1080

ggcgagcagg atgcgaccat ccacctcaaa gtctttgcaa aacccaaaat cacatatgta   1140

gagaaccaga ctgccatgga attagaggag caggtcactc ttacctgtga agcctccgga   1200

gaccccattc cctccatcac ctggaggact tctacccgga acatcagcag cgaagaaaag   1260

actctggatg ggcacatggt ggtgcgtagc catgcccgtg tgtcgtcgct gaccctgaag   1320

agcatccagt acactgatgc cggagagtac atctgcaccg ccagcaacac catcggccag   1380

gactcccagt ccatgtacct tgaagtgcaa tatgccccaa agctacaggg ccctgtggct   1440

gtgtacactt gggaggggaa ccaggtgaac atcacctgcg aggtatttgc ctatcccagt   1500

gccacgatct catggtttcg ggatggccag ctgctgccaa gctccaatta cagcaatatc   1560

aagatctaca acaccccctc tgccagctat ctggaggtga ccccagactc tgagaatgat   1620

tttgggaact acaactgtac tgcagtgaac cgcattgggc aggagtcctt ggaattcatc   1680

cttgttcaag cagacacccc ctcttcacca tccatcgacc aggtggagcc atactccagc   1740

acagcccagg tgcagtttga tgaaccagag gccacaggtg gggtgcccat cctcaaatac   1800

aaagctgagt ggagagcagt tggtgaagaa gtatggcatt ccaagtggta tgatgccaag   1860

gaagccagca tggagggcat cgtcaccatc gtgggcctga agcccgaaac aacgtacgcc   1920

gtaaggctgg cggcgctcaa tggcaaaggg ctgggtgaga tcagcgcggc ctccgagttc   1980

aagacgcagc cagtccaagg ggaacccagt gcacctaagc tcgaagggca gatgggagag   2040

gatggaaact ctattaaagt gaacctgatc aagcaggatg acggcggctc ccccatcaga   2100

cactatctgg tcaggtaccg agcgctctcc tccgagtgga aaccagagat caggctcccg   2160

tctggcagtg accacgtcat gctgaagtcc ctggactgga atgctgagta tgaggtctac   2220

gtggtggctg agaaccagca aggaaaatcc aaggcggctc attttgtgtt caggacctcg   2280

gcccagccca cagccatccc agccaacggc agccccacct caggcctgag caccggggcc   2340

atcgtgggca tcctcatcgt catcttcgtc ctgctcctgg tggttgtgga catcacctgc   2400

tacttcctga acaagtgtgg cctgttcatg tgcattgcgg tcaacctgtg tggaaaagcc   2460

gggcccgggg ccaagggcaa ggacatggag gagggcaagg ccgccttctc gaaagatgag   2520

tccaaggagc ccatcgtgga ggttcgaacg gaggaggaga ggaccccaaa ccatgatgga   2580

gggaaacaca cagagcccaa cgagaccacg ccactgacgg agcccgagaa gggccccgta   2640

gaagcaaagc cagagtgcca ggagacagaa acgaagccag cgccagccga agtcaagacg   2700

gtccccaatg acgccacaca gacaaaggag aacgagagca aagcatgatg ggtgaagaga   2760

accgagcaaa gatcaaaata aaaagtgaca cagcagcttc accagagcat ttccaacacc   2820

acagacacac acacgcacac acacacacaa ttctaggcta gtttctggtc ttatcattga   2880

gttacagctt agtgatgatt ttaagacaaa acaaacaaac aaaaaaaaaa aaaaaccatg   2940

gtacccggat cctcgaattc                                               2960


<210>  2875
<211>  848
<212>  PRT
<213>  Homosapiens

<400>  2875

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu 
        595                 600                 605             


Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys 
    610                 615                 620                 


Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg 
625                 630                 635                 640 


Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser 
                645                 650                 655     


Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val 
            660                 665                 670         


Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe 
        675                 680                 685             


Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser 
    690                 695                 700                 


Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly Ile Leu Ile Val 
705                 710                 715                 720 


Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr Cys Tyr Phe Leu 
                725                 730                 735     


Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn Leu Cys Gly Lys 
            740                 745                 750         


Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu Gly Lys Ala Ala 
        755                 760                 765             


Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu Val Arg Thr Glu 
    770                 775                 780                 


Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His Thr Glu Pro Asn 
785                 790                 795                 800 


Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro Val Glu Ala Lys 
                805                 810                 815     


Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro Ala Glu Val Lys 
            820                 825                 830         


Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
        835                 840                 845             


<210>  2876
<211>  4050
<212>  DNA
<213>  Homosapiens

<400>  2876
gcgcgtgaac gcagctcggc tgccgctggc aggaaacaat tctgcaaaaa taatcatact     60

cagcctggca attgtctgcc cctaggtctg tcgctcagcc gccgtccaca ctcgctgcag    120

gggggggggg cacagaattt accgcggcaa gaacatccct cccagccagc agattacaat    180

gctgcaaact aaggatctca tctggacttt gtttttcctg ggaactgcag tttctctgca    240

ggtggatatt gttcccagcc agggggagat cagcgttgga gagtccaaat tcttcttatg    300

ccaagtggca ggagatgcca aagataaaga catctcctgg ttctccccca atggagaaaa    360

gctcacccca aaccagcagc ggatctcagt ggtgtggaat gatgattcct cctccaccct    420

caccatctat aacgccaaca tcgacgacgc cggcatttac aagtgtgtgg ttacaggcga    480

ggatggcagt gagtcagagg ccaccgtcaa cgtgaagatc tttcagaagc tcatgttcaa    540

gaatgcgcca accccacagg agttccggga gggggaagat gccgtgattg tgtgtgatgt    600

ggtcagctcc ctcccaccaa ccatcatctg gaaacacaaa ggccgagatg tcatcctgaa    660

aaaagatgtc cgattcatag tcctgtccaa caactacctg cagatccggg gcatcaagaa    720

aacagatgag ggcacttatc gctgtgaggg cagaatcctg gcacgggggg agatcaactt    780

caaggacatt caggtcattg tgaatgtgcc acctaccatc caggccaggc agaatattgt    840

gaatgccacc gccaacctcg gccagtccgt caccctggtg tgcgatgccg aaggcttccc    900

agagcccacc atgagctgga caaaggatgg ggaacagata gagcaagagg aagacgatga    960

gaagtacatc ttcagcgacg atagttccca gctgaccatc aaaaaggtgg ataagaacga   1020

cgaggctgag tacatctgca ttgctgagaa caaggctggc gagcaggatg cgaccatcca   1080

cctcaaagtc tttgcaaaac ccaaaatcac atatgtagag aaccagactg ccatggaatt   1140

agaggagcag gtcactctta cctgtgaagc ctccggagac cccattccct ccatcacctg   1200

gaggacttct acccggaaca tcagcagcga agaaaaggct tcgtggactc gaccagagaa   1260

gcaagagact ctggatgggc acatggtggt gcgtagccat gcccgtgtgt cgtcgctgac   1320

cctgaagagc atccagtaca ctgatgccgg agagtacatc tgcaccgcca gcaacaccat   1380

cggccaggac tcccagtcca tgtaccttga agtgcaatat gccccaaagc tacagggccc   1440

tgtggctgtg tacacttggg aggggaacca ggtgaacatc acctgcgagg tatttgccta   1500

tcccagtgcc acgatctcat ggtttcggga tggccagctg ctgccaagct ccaattacag   1560

caatatcaag atctacaaca ccccctctgc cagctatctg gaggtgaccc cagactctga   1620

gaatgatttt gggaactaca actgtactgc agtgaaccgc attgggcagg agtccttgga   1680

attcatcctt gttcaagcag acaccccctc ttcaccatcc atcgaccagg tggagccata   1740

ctccagcaca gcccaggtgc agtttgatga accagaggcc acaggtgggg tgcccatcct   1800

caaatacaaa gctgagtgga gagcagtggg tgaagaagta tggcattcca agtggtatga   1860

tgccaaggaa gccagcatgg agggcatcgt caccatcgtg ggcctgaagc ccgaaacaac   1920

gtacgccgta aggctggcgg cgctcaatgg caaagggctg ggtgagatca gcgcggcctc   1980

cgagttcaag acgcagccag tccaagggga acccagtgca cctaagctcg aagggcagat   2040

gggagaggat ggaaactcta ttaaagtgaa cctgatcaag caggatgacg gcggctcccc   2100

catcagacac tatctggtca ggtaccgagc gctctcctcc gagtggaaac cagagatcag   2160

gctcccgtct ggcagtgacc acgtcatgct gaagtccctg gactggaatg ctgagtatga   2220

ggtctacgtg gtggctgaga accagcaagg aaaatccaag gcggctcatt ttgtgttcag   2280

gacctcggcc cagcccacag ccatcccagc caacggcagc cccacctcag gcctgagcac   2340

cggggccatc gtgggcatcc tcatcgtcat cttcgtcctg ctcctggtgg ttgtggacat   2400

cacctgctac ttcctgaaca agtgtggcct gttcatgtgc attgcggtca acctgtgtgg   2460

aaaagccggg cccggggcca agggcaagga catggaggag ggcaaggccg ccttctcgaa   2520

agatgagtcc aaggagccca tcgtggaggt tcgaacggag gaggagagga ccccaaacca   2580

tgatggaggg aaacacacag agcccaacga gaccacgcca ctgacggagc ccgagaaggg   2640

ccccgtagaa gcaaagccag agtgccagga gacagaaacg aagccagcgc cagccgaagt   2700

caagacggtc cccaatgacg ccacacagac aaaggagaac gagaacaaag catgatgggt   2760

gaagagaacc gagcaaagat caaaataaaa agtgacacag cagcttcacc agagcatttc   2820

caacaccaca gacacacaca cgcacgcaca cacacaaaca cacatgcaca cacacacatc   2880

tcatttctct agtgtctttt gcctttaaaa aaaactaaac agataaaaca tgggaatctc   2940

ctttttgtag gtttatagaa agggtccctt tgttgcacac tcacttgtaa gaaaatgaga   3000

caaaaaggtt aaacccacag ccaaactagg acactccgtt ccctgaaacc gttaaaaaat   3060

caaacaaaag gaccccaaat taagaatcta ggaagctcag aaacgaaatc taggttcagg   3120

aagaccacac ttggtgttac ccgattggca cagaccagtt tcagagaaat actttcaggc   3180

actaagacta atcgaatgaa caaagtccac agtttatttt tatactttca gtcaagtttg   3240

aactctgtaa aacctcataa ataagttata atttctgttc actttgtatt tgttcagtat   3300

gcaaagtgtg tcaccctttc tagctgaatt caattcccac gtagactctt attttatagg   3360

acgaatgcca aattgcagct tctgggggta gatctcaatt tgcagtattc agacttcttt   3420

ttctttcttt tacattcttt tttctttctt tctttctgcc aactttgttt tccagtgttt   3480

acaaggtgac aaatgtttga ctttggttgt gtttaaatgt ccgtgtaaaa tagctgcctt   3540

ttatttttta aggtaacaaa taccacctag aggtaggtag gatcatccca cgcttgcttt   3600

agcacaggac aactttacaa aacatgattg tttacagctg ctcttcccct cttttctgat   3660

ctgcagtttt tgcctgggtc ccactcaggt gaaaatccat ctcattctgg aatggttttg   3720

cttttgaatt tttggttatt tttgtgtttc tttgggggtt agaccacttt ctgattagcc   3780

gccacctgcc tgcatctgtg aaaagggatc tgctcccagg cgttctcacc cttcttttga   3840

aggactcctt aggctttgtt gaatgaagca gagaagattg tatagttggg gctggtcttg   3900

gtgaacacac attattaccc cacacatccc ctttgtgtag aaagccaaat aaaatctata   3960

cataccaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                    4050


<210>  2877
<211>  858
<212>  PRT
<213>  Homosapiens

<400>  2877

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His 
        355                 360                 365             


Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser 
    370                 375                 380                 


Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr 
385                 390                 395                 400 


Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro 
                405                 410                 415     


Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val 
            420                 425                 430         


Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp 
        435                 440                 445             


Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys 
    450                 455                 460                 


Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser 
465                 470                 475                 480 


Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly 
                485                 490                 495     


Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser 
            500                 505                 510         


Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln 
        515                 520                 525             


Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys 
    530                 535                 540                 


Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr 
545                 550                 555                 560 


Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu 
                565                 570                 575     


Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys 
            580                 585                 590         


Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val 
        595                 600                 605             


Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
    610                 615                 620                 


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
625                 630                 635                 640 


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
                645                 650                 655     


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
            660                 665                 670         


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
        675                 680                 685             


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
    690                 695                 700                 


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
705                 710                 715                 720 


Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 
                725                 730                 735     


Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe 
            740                 745                 750         


Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 
        755                 760                 765             


Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 
    770                 775                 780                 


Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 
785                 790                 795                 800 


His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 
                805                 810                 815     


Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr 
            820                 825                 830         


Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala 
        835                 840                 845             


Thr Gln Thr Lys Glu Asn Glu Asn Lys Ala 
    850                 855             


<210>  2878
<211>  2330
<212>  DNA
<213>  Homosapiens

<400>  2878
cttggtcccg ccccgggccc ctggctcctg gccccgcccc agcccaggca ggtcactgcg     60

ccatttcctg tccaaagctg ggcgaatcag ggattccggt tcacaatgga tgctgataaa    120

gagaaagatt tgcagaaatt tcttaaaaat gtggatgaaa tctccaattt aattcaggag    180

atgaattctg atgacccagt tgtgcaacag aaagctgtcc tggagacaga aaagagacta    240

ctgcttatgg aggaagacca ggaggaggat gaatgcagga ccaccttgaa caagactatg    300

atcagtcctc cacaaactgc tatgaagagt gcagaagaaa taaactcaga ggccttcttg    360

gcatctgtgg agaaggatgc aaaggaacga gccaagagaa gaagggaaaa caaagtcttg    420

gcggatgccc taaaagaaaa agggaatgaa gcatttgctg aaggcaatta tgaaacagct    480

atcctgcgct acagtgaggg tttggagaag ctgaaggaca tgaaagtgct gtacaccaac    540

cgagcccagg cttatatgaa acttgaggac tatgagaagg cactggtgga ttgtgagtgg    600

gctctcaagt gtgatgaaaa atgcacaaaa gcatattttc acatgggaaa agccaacctg    660

gccctgaaga actacagtgt gtctagagag tgttataaga agatcttaga aataaacccc    720

aagctgcaaa cccaggtgaa aggttacctg aatcaagtag atcttcagga aaaagcagac    780

cttcaagaaa aggaagccca cgaactgctg gattcaggaa agaacacagc cgtgaccacc    840

aagaacctcc tggagaccct ttccaagcct gaccagatcc ccttgttcta tgctgggggg    900

attgagatcc tgactgaaat gataaatgag tgcacagaac aaactttatt cagaatgcac    960

aatggattta gtatcatcag tgacaacgag gtcataagaa ggtgtttttc cacagcagga   1020

aatgatgcag ttgaagaaat ggtctgtgtg tctgttctca agctctggca agcagtgtgc   1080

agcaggaacg aggaaaacca gcgtgtgcta gtgatacacc atgacagggc caggctgttg   1140

gccgccctct tgtcctccaa ggtcctggcc atccggcagc agagctttgc cctgctgctg   1200

catctcgccc agactgagag cggacggagc ctgatcatca accaccttga cctgaccaga   1260

ttattggaag cgctggtgtc atttcttgat ttctcggata aggaggccaa cactgctatg   1320

ggactgttca cagacttggc tctggaagaa agattccaag tctggttcca ggccaacctt   1380

ccaggtgttc tccctgcact cacaggcgtt ctgaagacag atcccaaggt aagcagctcc   1440

tcggctctgt gccagtgcat tgccatcatg ggaaacctca gtgctgagcc cactacccga   1500

agacacatgg cggcctgtga ggaatttggg gatggctgct tgagcctcct ggccaggtgt   1560

gaggaggatg tggacctgtt cagagaggtt atctacacac tcctgggact catgatgaac   1620

ctgtgtcttc aggctccctt tgtctctgag gtttgggctg tggaggtgag cagaaggtgc   1680

ctgtctttac taaacagcca ggatggagga atcctgacaa gagctgctgg tgttctgagc   1740

cggacccttt cttcctctct gaaaattgtt gaggaggcct tgcgagcagg agtggtaaag   1800

aaaatgatga aattcctgaa gacaggaggt gagactgcat cacgttatgc tataaagata   1860

ctagctatct gcacgaatag ttatcatgaa gctcgggaag aagtaataag actggataaa   1920

aagttgagcg ttatgatgaa gctgctcagc tcggaggatg aggttctggt gggcaacgct   1980

gccctctgcc ttggtaactg catggaggtg cccaacgttg cgtcttccct gctaaagacg   2040

gaccttttgc aggtcttgtt aaagcttgca ggcagtgaca cacagaagac ggccgtgcag   2100

gtgaacgcag gcattgctct ggggaagctg tgcacagctg agcccagatt tgctgctcaa   2160

ctgagaaagc ttcatggcct agaaattctc aactctacga tgaaatacat cagtgattct   2220

tgagagagac agggtttgtg tgcatttggg gaacacacag atgcacaccg tgtgttgttc   2280

ctatgctaat aaagaccttt gatgtatcca cttcaaaaaa aaaaaaaaaa              2330


<210>  2879
<211>  705
<212>  PRT
<213>  Homosapiens

<400>  2879

Met Asp Ala Asp Lys Glu Lys Asp Leu Gln Lys Phe Leu Lys Asn Val 
1               5                   10                  15      


Asp Glu Ile Ser Asn Leu Ile Gln Glu Met Asn Ser Asp Asp Pro Val 
            20                  25                  30          


Val Gln Gln Lys Ala Val Leu Glu Thr Glu Lys Arg Leu Leu Leu Met 
        35                  40                  45              


Glu Glu Asp Gln Glu Glu Asp Glu Cys Arg Thr Thr Leu Asn Lys Thr 
    50                  55                  60                  


Met Ile Ser Pro Pro Gln Thr Ala Met Lys Ser Ala Glu Glu Ile Asn 
65                  70                  75                  80  


Ser Glu Ala Phe Leu Ala Ser Val Glu Lys Asp Ala Lys Glu Arg Ala 
                85                  90                  95      


Lys Arg Arg Arg Glu Asn Lys Val Leu Ala Asp Ala Leu Lys Glu Lys 
            100                 105                 110         


Gly Asn Glu Ala Phe Ala Glu Gly Asn Tyr Glu Thr Ala Ile Leu Arg 
        115                 120                 125             


Tyr Ser Glu Gly Leu Glu Lys Leu Lys Asp Met Lys Val Leu Tyr Thr 
    130                 135                 140                 


Asn Arg Ala Gln Ala Tyr Met Lys Leu Glu Asp Tyr Glu Lys Ala Leu 
145                 150                 155                 160 


Val Asp Cys Glu Trp Ala Leu Lys Cys Asp Glu Lys Cys Thr Lys Ala 
                165                 170                 175     


Tyr Phe His Met Gly Lys Ala Asn Leu Ala Leu Lys Asn Tyr Ser Val 
            180                 185                 190         


Ser Arg Glu Cys Tyr Lys Lys Ile Leu Glu Ile Asn Pro Lys Leu Gln 
        195                 200                 205             


Thr Gln Val Lys Gly Tyr Leu Asn Gln Val Asp Leu Gln Glu Lys Ala 
    210                 215                 220                 


Asp Leu Gln Glu Lys Glu Ala His Glu Leu Leu Asp Ser Gly Lys Asn 
225                 230                 235                 240 


Thr Ala Val Thr Thr Lys Asn Leu Leu Glu Thr Leu Ser Lys Pro Asp 
                245                 250                 255     


Gln Ile Pro Leu Phe Tyr Ala Gly Gly Ile Glu Ile Leu Thr Glu Met 
            260                 265                 270         


Ile Asn Glu Cys Thr Glu Gln Thr Leu Phe Arg Met His Asn Gly Phe 
        275                 280                 285             


Ser Ile Ile Ser Asp Asn Glu Val Ile Arg Arg Cys Phe Ser Thr Ala 
    290                 295                 300                 


Gly Asn Asp Ala Val Glu Glu Met Val Cys Val Ser Val Leu Lys Leu 
305                 310                 315                 320 


Trp Gln Ala Val Cys Ser Arg Asn Glu Glu Asn Gln Arg Val Leu Val 
                325                 330                 335     


Ile His His Asp Arg Ala Arg Leu Leu Ala Ala Leu Leu Ser Ser Lys 
            340                 345                 350         


Val Leu Ala Ile Arg Gln Gln Ser Phe Ala Leu Leu Leu His Leu Ala 
        355                 360                 365             


Gln Thr Glu Ser Gly Arg Ser Leu Ile Ile Asn His Leu Asp Leu Thr 
    370                 375                 380                 


Arg Leu Leu Glu Ala Leu Val Ser Phe Leu Asp Phe Ser Asp Lys Glu 
385                 390                 395                 400 


Ala Asn Thr Ala Met Gly Leu Phe Thr Asp Leu Ala Leu Glu Glu Arg 
                405                 410                 415     


Phe Gln Val Trp Phe Gln Ala Asn Leu Pro Gly Val Leu Pro Ala Leu 
            420                 425                 430         


Thr Gly Val Leu Lys Thr Asp Pro Lys Val Ser Ser Ser Ser Ala Leu 
        435                 440                 445             


Cys Gln Cys Ile Ala Ile Met Gly Asn Leu Ser Ala Glu Pro Thr Thr 
    450                 455                 460                 


Arg Arg His Met Ala Ala Cys Glu Glu Phe Gly Asp Gly Cys Leu Ser 
465                 470                 475                 480 


Leu Leu Ala Arg Cys Glu Glu Asp Val Asp Leu Phe Arg Glu Val Ile 
                485                 490                 495     


Tyr Thr Leu Leu Gly Leu Met Met Asn Leu Cys Leu Gln Ala Pro Phe 
            500                 505                 510         


Val Ser Glu Val Trp Ala Val Glu Val Ser Arg Arg Cys Leu Ser Leu 
        515                 520                 525             


Leu Asn Ser Gln Asp Gly Gly Ile Leu Thr Arg Ala Ala Gly Val Leu 
    530                 535                 540                 


Ser Arg Thr Leu Ser Ser Ser Leu Lys Ile Val Glu Glu Ala Leu Arg 
545                 550                 555                 560 


Ala Gly Val Val Lys Lys Met Met Lys Phe Leu Lys Thr Gly Gly Glu 
                565                 570                 575     


Thr Ala Ser Arg Tyr Ala Ile Lys Ile Leu Ala Ile Cys Thr Asn Ser 
            580                 585                 590         


Tyr His Glu Ala Arg Glu Glu Val Ile Arg Leu Asp Lys Lys Leu Ser 
        595                 600                 605             


Val Met Met Lys Leu Leu Ser Ser Glu Asp Glu Val Leu Val Gly Asn 
    610                 615                 620                 


Ala Ala Leu Cys Leu Gly Asn Cys Met Glu Val Pro Asn Val Ala Ser 
625                 630                 635                 640 


Ser Leu Leu Lys Thr Asp Leu Leu Gln Val Leu Leu Lys Leu Ala Gly 
                645                 650                 655     


Ser Asp Thr Gln Lys Thr Ala Val Gln Val Asn Ala Gly Ile Ala Leu 
            660                 665                 670         


Gly Lys Leu Cys Thr Ala Glu Pro Arg Phe Ala Ala Gln Leu Arg Lys 
        675                 680                 685             


Leu His Gly Leu Glu Ile Leu Asn Ser Thr Met Lys Tyr Ile Ser Asp 
    690                 695                 700                 


Ser 
705 


<210>  2880
<211>  2543
<212>  DNA
<213>  Homosapiens

<400>  2880
cggacccgag gagcaggaag cggcggctcc ttcggccacc caggcagcag ccacagcggg     60

gagtgcgcgg cgcggggaca ggaagagagg ggcaatggct gccgacccca ccgagctgcg    120

gctgggcagc ctccccgtct tcacccgcga cgacttcgag ggcgactggc gcctagtggc    180

cagcggcggc ttcagccagg tgttccaggc gcggcacagg cgctggcgga cggagtacgc    240

catcaagtgc gccccctgcc ttccacccga cgccgccagc tctgatgtga attacctcat    300

tgaagaagct gccaaaatga agaagatcaa gtttcagcac atcgtgtcta tctacggggt    360

gtgcaagcag cccctgggta ttgtgatgga gtttatggcc aacggctccc tggagaaggt    420

gctgtccacc cacagcctct gctggaagct caggttccgc atcatccatg agaccagctt    480

ggccatgaac ttcctgcaca gcattaagcc gcctctgctc cacctggacc tcaagccggg    540

caacatactc ctggacagca acatgcatgt caaaatttca gacttcggcc tgtccaagtg    600

gatggaacag tccacccgga tgcagtacat cgagaggtcg gctctgcggg gcatgctcag    660

ctacatcccc cctgagatgt tcctggagag taacaaggcc ccaggaccta aatatgatgt    720

gtacagcttt gcaattgtca tctgggagct actcactcag aagaaaccat actcagggtt    780

caacatgatg atgattatta tccgagtggc ggcaggcatg cggccctccc tacagcctgt    840

ctctgaccaa tggccaagcg aggcccagca gatggtggac ctgatgaaac gctgctggga    900

ccaggacccc aagaagaggc catgctttct agacattacc atcgagacag acatactgct    960

gtcactgctg cagagtcgtg tggcagtccc agagagcaag gccctggcca ggaaggtgtc   1020

ctgcaagctg tcgctgcgcc agcccgggga ggttaatgag gacatcagcc aggaactgat   1080

ggacagtgac tcaggaaact acctgaagcg ggcccttcag ctctccgacc gtaagaattt   1140

ggtcccgaga gatgaggaac tgtgtatcta tgagaacaag gtcacccccc tccacttcct   1200

ggtggcccag ggcagtgtgg agcaggtgag gttgctgctg gcccacgagg tagacgtgga   1260

ctgccagacg gcctctggat acacgcccct cctgatcgcc gcccaggacc agcaacccga   1320

cctctgtgcc ctgcttttgg cacatggtgc tgatgccaac cgagtggatg aggatggctg   1380

ggccccactg cactttgcag cccagaatgg ggatgacggc actgcgcgcc tgctcctgga   1440

ccacggggcc tgtgtggatg cccaggaacg tgaagggtgg acccctcttc acctggctgc   1500

acagaataac tttgagaatg tggcacggct tctggtctcc cgtcaggctg accccaacct   1560

gcatgaggct gagggcaaga cccccctcca tgtggccgcc tactttggcc atgttagcct   1620

ggtcaagctg ctgaccagcc agggggctga gttggatgct cagcagagaa acctgagaac   1680

accactgcac ctggcagtag agcggggcaa agtgagggcc atccaacacc tgctgaagag   1740

tggagcggtc cctgatgccc ttgaccagag cggctacggc ccactgcaca ctgcagctgc   1800

caggggcaaa tacctgatct gcaagatgct gctcaggtac ggagccagcc ttgagctgcc   1860

cacccaccag ggctggacac ccctgcatct agcagcctac aagggccacc tggagatcat   1920

ccatctgctg gcagagagcc acgcaaacat gggtgctctt ggagctgtga actggactcc   1980

cctgcaccta gctgcacgcc acggggagga ggcggtggtg tcagcactgc tgcagtgtgg   2040

ggctgacccc aatgctgcag agcagtcagg ctggacaccc ctccacctgg cggtccagag   2100

gagcaccttc ctgagtgtca tcaacctcct agaacatcac gcaaatgtcc acgcccgcaa   2160

caaggtgggc tggacacccg cccacctggc cgccctcaag ggcaacacag ccatcctcaa   2220

agtgctggtc gaggcaggcg cccagctgga cgtccaggat ggagtgagct gcacacccct   2280

gcaactggcc ctccgcagcc gaaagcaggg catcatgtcc ttcctagagg gcaaggagcc   2340

gtcagtggcc actctgggtg gttctaagcc aggagccgag atggaaattt agacaacttg   2400

gccagccgtg gtggctcacg tctgtaatcc cagcactttg ggaggctgag gcaggcagat   2460

cacctgatat caagagtttg aggccagcct ggccaacatg gcaaaaccct gtctctgcta   2520

aaaatacaaa atttagctgg gta                                           2543


<210>  2881
<211>  765
<212>  PRT
<213>  Homosapiens

<400>  2881

Met Ala Ala Asp Pro Thr Glu Leu Arg Leu Gly Ser Leu Pro Val Phe 
1               5                   10                  15      


Thr Arg Asp Asp Phe Glu Gly Asp Trp Arg Leu Val Ala Ser Gly Gly 
            20                  25                  30          


Phe Ser Gln Val Phe Gln Ala Arg His Arg Arg Trp Arg Thr Glu Tyr 
        35                  40                  45              


Ala Ile Lys Cys Ala Pro Cys Leu Pro Pro Asp Ala Ala Ser Ser Asp 
    50                  55                  60                  


Val Asn Tyr Leu Ile Glu Glu Ala Ala Lys Met Lys Lys Ile Lys Phe 
65                  70                  75                  80  


Gln His Ile Val Ser Ile Tyr Gly Val Cys Lys Gln Pro Leu Gly Ile 
                85                  90                  95      


Val Met Glu Phe Met Ala Asn Gly Ser Leu Glu Lys Val Leu Ser Thr 
            100                 105                 110         


His Ser Leu Cys Trp Lys Leu Arg Phe Arg Ile Ile His Glu Thr Ser 
        115                 120                 125             


Leu Ala Met Asn Phe Leu His Ser Ile Lys Pro Pro Leu Leu His Leu 
    130                 135                 140                 


Asp Leu Lys Pro Gly Asn Ile Leu Leu Asp Ser Asn Met His Val Lys 
145                 150                 155                 160 


Ile Ser Asp Phe Gly Leu Ser Lys Trp Met Glu Gln Ser Thr Arg Met 
                165                 170                 175     


Gln Tyr Ile Glu Arg Ser Ala Leu Arg Gly Met Leu Ser Tyr Ile Pro 
            180                 185                 190         


Pro Glu Met Phe Leu Glu Ser Asn Lys Ala Pro Gly Pro Lys Tyr Asp 
        195                 200                 205             


Val Tyr Ser Phe Ala Ile Val Ile Trp Glu Leu Leu Thr Gln Lys Lys 
    210                 215                 220                 


Pro Tyr Ser Gly Phe Asn Met Met Met Ile Ile Ile Arg Val Ala Ala 
225                 230                 235                 240 


Gly Met Arg Pro Ser Leu Gln Pro Val Ser Asp Gln Trp Pro Ser Glu 
                245                 250                 255     


Ala Gln Gln Met Val Asp Leu Met Lys Arg Cys Trp Asp Gln Asp Pro 
            260                 265                 270         


Lys Lys Arg Pro Cys Phe Leu Asp Ile Thr Ile Glu Thr Asp Ile Leu 
        275                 280                 285             


Leu Ser Leu Leu Gln Ser Arg Val Ala Val Pro Glu Ser Lys Ala Leu 
    290                 295                 300                 


Ala Arg Lys Val Ser Cys Lys Leu Ser Leu Arg Gln Pro Gly Glu Val 
305                 310                 315                 320 


Asn Glu Asp Ile Ser Gln Glu Leu Met Asp Ser Asp Ser Gly Asn Tyr 
                325                 330                 335     


Leu Lys Arg Ala Leu Gln Leu Ser Asp Arg Lys Asn Leu Val Pro Arg 
            340                 345                 350         


Asp Glu Glu Leu Cys Ile Tyr Glu Asn Lys Val Thr Pro Leu His Phe 
        355                 360                 365             


Leu Val Ala Gln Gly Ser Val Glu Gln Val Arg Leu Leu Leu Ala His 
    370                 375                 380                 


Glu Val Asp Val Asp Cys Gln Thr Ala Ser Gly Tyr Thr Pro Leu Leu 
385                 390                 395                 400 


Ile Ala Ala Gln Asp Gln Gln Pro Asp Leu Cys Ala Leu Leu Leu Ala 
                405                 410                 415     


His Gly Ala Asp Ala Asn Arg Val Asp Glu Asp Gly Trp Ala Pro Leu 
            420                 425                 430         


His Phe Ala Ala Gln Asn Gly Asp Asp Gly Thr Ala Arg Leu Leu Leu 
        435                 440                 445             


Asp His Gly Ala Cys Val Asp Ala Gln Glu Arg Glu Gly Trp Thr Pro 
    450                 455                 460                 


Leu His Leu Ala Ala Gln Asn Asn Phe Glu Asn Val Ala Arg Leu Leu 
465                 470                 475                 480 


Val Ser Arg Gln Ala Asp Pro Asn Leu His Glu Ala Glu Gly Lys Thr 
                485                 490                 495     


Pro Leu His Val Ala Ala Tyr Phe Gly His Val Ser Leu Val Lys Leu 
            500                 505                 510         


Leu Thr Ser Gln Gly Ala Glu Leu Asp Ala Gln Gln Arg Asn Leu Arg 
        515                 520                 525             


Thr Pro Leu His Leu Ala Val Glu Arg Gly Lys Val Arg Ala Ile Gln 
    530                 535                 540                 


His Leu Leu Lys Ser Gly Ala Val Pro Asp Ala Leu Asp Gln Ser Gly 
545                 550                 555                 560 


Tyr Gly Pro Leu His Thr Ala Ala Ala Arg Gly Lys Tyr Leu Ile Cys 
                565                 570                 575     


Lys Met Leu Leu Arg Tyr Gly Ala Ser Leu Glu Leu Pro Thr His Gln 
            580                 585                 590         


Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Lys Gly His Leu Glu Ile 
        595                 600                 605             


Ile His Leu Leu Ala Glu Ser His Ala Asn Met Gly Ala Leu Gly Ala 
    610                 615                 620                 


Val Asn Trp Thr Pro Leu His Leu Ala Ala Arg His Gly Glu Glu Ala 
625                 630                 635                 640 


Val Val Ser Ala Leu Leu Gln Cys Gly Ala Asp Pro Asn Ala Ala Glu 
                645                 650                 655     


Gln Ser Gly Trp Thr Pro Leu His Leu Ala Val Gln Arg Ser Thr Phe 
            660                 665                 670         


Leu Ser Val Ile Asn Leu Leu Glu His His Ala Asn Val His Ala Arg 
        675                 680                 685             


Asn Lys Val Gly Trp Thr Pro Ala His Leu Ala Ala Leu Lys Gly Asn 
    690                 695                 700                 


Thr Ala Ile Leu Lys Val Leu Val Glu Ala Gly Ala Gln Leu Asp Val 
705                 710                 715                 720 


Gln Asp Gly Val Ser Cys Thr Pro Leu Gln Leu Ala Leu Arg Ser Arg 
                725                 730                 735     


Lys Gln Gly Ile Met Ser Phe Leu Glu Gly Lys Glu Pro Ser Val Ala 
            740                 745                 750         


Thr Leu Gly Gly Ser Lys Pro Gly Ala Glu Met Glu Ile 
        755                 760                 765 


<210>  2882
<211>  2643
<212>  DNA
<213>  Homosapiens

<400>  2882
ggcagccgtc cggggccgcc actctcctcg gccggtccct ggctcccgga ggcggccgcg     60

cgtggatgcg gcgggagctg gaagcctcaa gcagccggcg ccgtctctgc cccggggcgc    120

cctatggctt gaagagcctg gccacccagt ggctccaccg ccctgatgga tccactgaat    180

ctgtcctggt atgatgatga tctggagagg cagaactgga gccggccctt caacgggtca    240

gacgggaagg cggacagacc ccactacaac tactatgcca cactgctcac cctgctcatc    300

gctgtcatcg tcttcggcaa cgtgctggtg tgcatggctg tgtcccgcga gaaggcgctg    360

cagaccacca ccaactacct gatcgtcagc ctcgcagtgg ccgacctcct cgtcgccaca    420

ctggtcatgc cctgggttgt ctacctggag gtggtaggtg agtggaaatt cagcaggatt    480

cactgtgaca tcttcgtcac tctggacgtc atgatgtgca cggcgagcat cctgaacttg    540

tgtgccatca gcatcgacag gtacacagct gtggccatgc ccatgctgta caatacgcgc    600

tacagctcca agcgccgggt caccgtcatg atctccatcg tctgggtcct gtccttcacc    660

atctcctgcc cactcctctt cggactcaat aacgcagacc agaacgagtg catcattgcc    720

aacccggcct tcgtggtcta ctcctccatc gtctccttct acgtgccctt cattgtcacc    780

ctgctggtct acatcaagat ctacattgtc ctccgcagac gccgcaagcg agtcaacacc    840

aaacgcagca gccgagcttt cagggcccac ctgagggctc cactaaaggg caactgtact    900

caccccgagg acatgaaact ctgcaccgtt atcatgaagt ctaatgggag tttcccagtg    960

aacaggcgga gagtggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc   1020

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg   1080

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca   1140

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1200

atgcccaatg gcaaaacccg gacctccctc aagaccatga gccgtaggaa gctctcccag   1260

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1320

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1380

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1440

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgctgactc   1500

tgctgcctgc ccgcacagca gcctgcttcc cacctccctg cccaggccgg ccagcctcac   1560

ccttgcgaac cgtgagcagg aaggcctggg tggatcggcc tcctcttcac cccggcaggc   1620

cctgcagtgt tcgcttggct ccatgctcct cactgcccgc acaccctcac tctgccaggg   1680

cagtgctagt gagctgggca tggtaccagc cctggggctg ggccccccag ctcaggggca   1740

gctcatagag tcccccctcc cacctccagt ccccctatcc ttggcaccaa agatgcagcc   1800

gccttccttg accttcctct ggggctctag ggttgctgga gcctgagtca gggcccagag   1860

gctgagtttt ctctttgtgg ggcttggcgt ggagcaggcg gtggggagag atggacagtt   1920

cacaccctgc aaggcccaca ggaggcaagc aagctctctt gccgaggagc caggcaactt   1980

cagtcctggg agacccatgt aaataccaga ctgcaggttg gaccccagag attcccaagc   2040

caaaaacctt agctccctcc cgcaccccga tgtggacctc tactttccag gctagtccgg   2100

acccacctca ccccgttaca gctccccaag tggtttccac atgctctgag aagaggagcc   2160

ctcatcttga agggcccagg agggtctatg gggagaggaa ctccttggcc tagcccaccc   2220

tgctgccttc tgacggccct gcaatgtatc ccttctcaca gcacatgctg gccagcctgg   2280

ggcctggcag ggaggtcagg ccctggaact ctatctgggc ctgggctagg ggacatcaga   2340

ggttctttga gggactgcct ctgccacact ctgacgcaaa accactttcc ttttctattc   2400

cttctggcct ttcctctctc ctgtttccct tcccttccac tgcctctgcc ttagaggagc   2460

ccacggctaa gaggctgctg aaaaccatct ggcctggcct ggccctgccc tgaggaagga   2520

ggggaagctg cagcttggga gagcccctgg ggcctagact ctgtaacatc actatccatg   2580

caccaaacta ataaaacttt gacgagtcac cttccaggac ccctgggtaa aaaaaaaaaa   2640

aaa                                                                 2643


<210>  2883
<211>  443
<212>  PRT
<213>  Homosapiens

<400>  2883

Met Asp Pro Leu Asn Leu Ser Trp Tyr Asp Asp Asp Leu Glu Arg Gln 
1               5                   10                  15      


Asn Trp Ser Arg Pro Phe Asn Gly Ser Asp Gly Lys Ala Asp Arg Pro 
            20                  25                  30          


His Tyr Asn Tyr Tyr Ala Thr Leu Leu Thr Leu Leu Ile Ala Val Ile 
        35                  40                  45              


Val Phe Gly Asn Val Leu Val Cys Met Ala Val Ser Arg Glu Lys Ala 
    50                  55                  60                  


Leu Gln Thr Thr Thr Asn Tyr Leu Ile Val Ser Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Val Ala Thr Leu Val Met Pro Trp Val Val Tyr Leu Glu Val 
                85                  90                  95      


Val Gly Glu Trp Lys Phe Ser Arg Ile His Cys Asp Ile Phe Val Thr 
            100                 105                 110         


Leu Asp Val Met Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile 
        115                 120                 125             


Ser Ile Asp Arg Tyr Thr Ala Val Ala Met Pro Met Leu Tyr Asn Thr 
    130                 135                 140                 


Arg Tyr Ser Ser Lys Arg Arg Val Thr Val Met Ile Ser Ile Val Trp 
145                 150                 155                 160 


Val Leu Ser Phe Thr Ile Ser Cys Pro Leu Leu Phe Gly Leu Asn Asn 
                165                 170                 175     


Ala Asp Gln Asn Glu Cys Ile Ile Ala Asn Pro Ala Phe Val Val Tyr 
            180                 185                 190         


Ser Ser Ile Val Ser Phe Tyr Val Pro Phe Ile Val Thr Leu Leu Val 
        195                 200                 205             


Tyr Ile Lys Ile Tyr Ile Val Leu Arg Arg Arg Arg Lys Arg Val Asn 
    210                 215                 220                 


Thr Lys Arg Ser Ser Arg Ala Phe Arg Ala His Leu Arg Ala Pro Leu 
225                 230                 235                 240 


Lys Gly Asn Cys Thr His Pro Glu Asp Met Lys Leu Cys Thr Val Ile 
                245                 250                 255     


Met Lys Ser Asn Gly Ser Phe Pro Val Asn Arg Arg Arg Val Glu Ala 
            260                 265                 270         


Ala Arg Arg Ala Gln Glu Leu Glu Met Glu Met Leu Ser Ser Thr Ser 
        275                 280                 285             


Pro Pro Glu Arg Thr Arg Tyr Ser Pro Ile Pro Pro Ser His His Gln 
    290                 295                 300                 


Leu Thr Leu Pro Asp Pro Ser His His Gly Leu His Ser Thr Pro Asp 
305                 310                 315                 320 


Ser Pro Ala Lys Pro Glu Lys Asn Gly His Ala Lys Asp His Pro Lys 
                325                 330                 335     


Ile Ala Lys Ile Phe Glu Ile Gln Thr Met Pro Asn Gly Lys Thr Arg 
            340                 345                 350         


Thr Ser Leu Lys Thr Met Ser Arg Arg Lys Leu Ser Gln Gln Lys Glu 
        355                 360                 365             


Lys Lys Ala Thr Gln Met Leu Ala Ile Val Leu Gly Val Phe Ile Ile 
    370                 375                 380                 


Cys Trp Leu Pro Phe Phe Ile Thr His Ile Leu Asn Ile His Cys Asp 
385                 390                 395                 400 


Cys Asn Ile Pro Pro Val Leu Tyr Ser Ala Phe Thr Trp Leu Gly Tyr 
                405                 410                 415     


Val Asn Ser Ala Val Asn Pro Ile Ile Tyr Thr Thr Phe Asn Ile Glu 
            420                 425                 430         


Phe Arg Lys Ala Phe Leu Lys Ile Leu His Cys 
        435                 440             


<210>  2884
<211>  2556
<212>  DNA
<213>  Homosapiens

<400>  2884
ggcagccgtc cggggccgcc actctcctcg gccggtccct ggctcccgga ggcggccgcg     60

cgtggatgcg gcgggagctg gaagcctcaa gcagccggcg ccgtctctgc cccggggcgc    120

cctatggctt gaagagcctg gccacccagt ggctccaccg ccctgatgga tccactgaat    180

ctgtcctggt atgatgatga tctggagagg cagaactgga gccggccctt caacgggtca    240

gacgggaagg cggacagacc ccactacaac tactatgcca cactgctcac cctgctcatc    300

gctgtcatcg tcttcggcaa cgtgctggtg tgcatggctg tgtcccgcga gaaggcgctg    360

cagaccacca ccaactacct gatcgtcagc ctcgcagtgg ccgacctcct cgtcgccaca    420

ctggtcatgc cctgggttgt ctacctggag gtggtaggtg agtggaaatt cagcaggatt    480

cactgtgaca tcttcgtcac tctggacgtc atgatgtgca cggcgagcat cctgaacttg    540

tgtgccatca gcatcgacag gtacacagct gtggccatgc ccatgctgta caatacgcgc    600

tacagctcca agcgccgggt caccgtcatg atctccatcg tctgggtcct gtccttcacc    660

atctcctgcc cactcctctt cggactcaat aacgcagacc agaacgagtg catcattgcc    720

aacccggcct tcgtggtcta ctcctccatc gtctccttct acgtgccctt cattgtcacc    780

ctgctggtct acatcaagat ctacattgtc ctccgcagac gccgcaagcg agtcaacacc    840

aaacgcagca gccgagcttt cagggcccac ctgagggctc cactaaagga ggctgcccgg    900

cgagcccagg agctggagat ggagatgctc tccagcacca gcccacccga gaggacccgg    960

tacagcccca tcccacccag ccaccaccag ctgactctcc ccgacccgtc ccaccatggt   1020

ctccacagca ctcccgacag ccccgccaaa ccagagaaga atgggcatgc caaagaccac   1080

cccaagattg ccaagatctt tgagatccag accatgccca atggcaaaac ccggacctcc   1140

ctcaagacca tgagccgtag gaagctctcc cagcagaagg agaagaaagc cactcagatg   1200

ctcgccattg ttctcggcgt gttcatcatc tgctggctgc ccttcttcat cacacacatc   1260

ctgaacatac actgtgactg caacatcccg cctgtcctgt acagcgcctt cacgtggctg   1320

ggctatgtca acagcgccgt gaaccccatc atctacacca ccttcaacat tgagttccgc   1380

aaggccttcc tgaagatcct ccactgctga ctctgctgcc tgcccgcaca gcagcctgct   1440

tcccacctcc ctgcccaggc cggccagcct cacccttgcg aaccgtgagc aggaaggcct   1500

gggtggatcg gcctcctctt caccccggca ggccctgcag tgttcgcttg gctccatgct   1560

cctcactgcc cgcacaccct cactctgcca gggcagtgct agtgagctgg gcatggtacc   1620

agccctgggg ctgggccccc cagctcaggg gcagctcata gagtcccccc tcccacctcc   1680

agtcccccta tccttggcac caaagatgca gccgccttcc ttgaccttcc tctggggctc   1740

tagggttgct ggagcctgag tcagggccca gaggctgagt tttctctttg tggggcttgg   1800

cgtggagcag gcggtgggga gagatggaca gttcacaccc tgcaaggccc acaggaggca   1860

agcaagctct cttgccgagg agccaggcaa cttcagtcct gggagaccca tgtaaatacc   1920

agactgcagg ttggacccca gagattccca agccaaaaac cttagctccc tcccgcaccc   1980

cgatgtggac ctctactttc caggctagtc cggacccacc tcaccccgtt acagctcccc   2040

aagtggtttc cacatgctct gagaagagga gccctcatct tgaagggccc aggagggtct   2100

atggggagag gaactccttg gcctagccca ccctgctgcc ttctgacggc cctgcaatgt   2160

atcccttctc acagcacatg ctggccagcc tggggcctgg cagggaggtc aggccctgga   2220

actctatctg ggcctgggct aggggacatc agaggttctt tgagggactg cctctgccac   2280

actctgacgc aaaaccactt tccttttcta ttccttctgg cctttcctct ctcctgtttc   2340

ccttcccttc cactgcctct gccttagagg agcccacggc taagaggctg ctgaaaacca   2400

tctggcctgg cctggccctg ccctgaggaa ggaggggaag ctgcagcttg ggagagcccc   2460

tggggcctag actctgtaac atcactatcc atgcaccaaa ctaataaaac tttgacgagt   2520

caccttccag gacccctggg taaaaaaaaa aaaaaa                             2556


<210>  2885
<211>  414
<212>  PRT
<213>  Homosapiens

<400>  2885

Met Asp Pro Leu Asn Leu Ser Trp Tyr Asp Asp Asp Leu Glu Arg Gln 
1               5                   10                  15      


Asn Trp Ser Arg Pro Phe Asn Gly Ser Asp Gly Lys Ala Asp Arg Pro 
            20                  25                  30          


His Tyr Asn Tyr Tyr Ala Thr Leu Leu Thr Leu Leu Ile Ala Val Ile 
        35                  40                  45              


Val Phe Gly Asn Val Leu Val Cys Met Ala Val Ser Arg Glu Lys Ala 
    50                  55                  60                  


Leu Gln Thr Thr Thr Asn Tyr Leu Ile Val Ser Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Val Ala Thr Leu Val Met Pro Trp Val Val Tyr Leu Glu Val 
                85                  90                  95      


Val Gly Glu Trp Lys Phe Ser Arg Ile His Cys Asp Ile Phe Val Thr 
            100                 105                 110         


Leu Asp Val Met Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile 
        115                 120                 125             


Ser Ile Asp Arg Tyr Thr Ala Val Ala Met Pro Met Leu Tyr Asn Thr 
    130                 135                 140                 


Arg Tyr Ser Ser Lys Arg Arg Val Thr Val Met Ile Ser Ile Val Trp 
145                 150                 155                 160 


Val Leu Ser Phe Thr Ile Ser Cys Pro Leu Leu Phe Gly Leu Asn Asn 
                165                 170                 175     


Ala Asp Gln Asn Glu Cys Ile Ile Ala Asn Pro Ala Phe Val Val Tyr 
            180                 185                 190         


Ser Ser Ile Val Ser Phe Tyr Val Pro Phe Ile Val Thr Leu Leu Val 
        195                 200                 205             


Tyr Ile Lys Ile Tyr Ile Val Leu Arg Arg Arg Arg Lys Arg Val Asn 
    210                 215                 220                 


Thr Lys Arg Ser Ser Arg Ala Phe Arg Ala His Leu Arg Ala Pro Leu 
225                 230                 235                 240 


Lys Glu Ala Ala Arg Arg Ala Gln Glu Leu Glu Met Glu Met Leu Ser 
                245                 250                 255     


Ser Thr Ser Pro Pro Glu Arg Thr Arg Tyr Ser Pro Ile Pro Pro Ser 
            260                 265                 270         


His His Gln Leu Thr Leu Pro Asp Pro Ser His His Gly Leu His Ser 
        275                 280                 285             


Thr Pro Asp Ser Pro Ala Lys Pro Glu Lys Asn Gly His Ala Lys Asp 
    290                 295                 300                 


His Pro Lys Ile Ala Lys Ile Phe Glu Ile Gln Thr Met Pro Asn Gly 
305                 310                 315                 320 


Lys Thr Arg Thr Ser Leu Lys Thr Met Ser Arg Arg Lys Leu Ser Gln 
                325                 330                 335     


Gln Lys Glu Lys Lys Ala Thr Gln Met Leu Ala Ile Val Leu Gly Val 
            340                 345                 350         


Phe Ile Ile Cys Trp Leu Pro Phe Phe Ile Thr His Ile Leu Asn Ile 
        355                 360                 365             


His Cys Asp Cys Asn Ile Pro Pro Val Leu Tyr Ser Ala Phe Thr Trp 
    370                 375                 380                 


Leu Gly Tyr Val Asn Ser Ala Val Asn Pro Ile Ile Tyr Thr Thr Phe 
385                 390                 395                 400 


Asn Ile Glu Phe Arg Lys Ala Phe Leu Lys Ile Leu His Cys 
                405                 410                 


<210>  2886
<211>  2265
<212>  DNA
<213>  Homosapiens

<400>  2886
acgcgggata cagggagggg ccatgtgcga accagggaga cctcatcttc caaccaagct     60

tgctgggctt gcatttaatc aatgcatggc cagagaacag gagcggaaca ttgcctagta    120

gaccctgagg ctttacaaca gtgctactga cccctatgag cctgatgctg gatgaccaac    180

cccctatgga ggcccagtat gcagaggagg gcccaggacc tgggatcttc agagcagagc    240

ctggagacca gcagcatccc atttctcagg cggtgtgctg gcgttccatg cgacgtggct    300

gtgcagtgct gggagccctg gggctgctgg ccggtgcagg tgttggctca tggctcctag    360

tgctgtatct gtgtcctgct gcctctcagc ccatttccgg gaccttgcag gatgaggaga    420

taactttgag ctgctcagag gccagcgctg aggaagctct gctccctgca ctccccaaaa    480

cagtatcttt cagaataaac agcgaagact tcttgctgga agcgcaagtg agggatcagc    540

cacgctggct cctggtctgc catgagggct ggagccccgc cctggggctg cagatctgct    600

ggagccttgg gcatctcaga ctcactcacc acaagggagt aaacctcact gacatcaaac    660

tcaacagttc ccaggagttt gctcagctct ctcctagact gggaggcttc ctggaggagg    720

cgtggcagcc caggaacaac tgcacttctg gtcaagttgt ttccctcaga tgctctgagt    780

gtggagcgag gcccctggct tcccggatag ttggtgggca gtctgtggct cctgggcgct    840

ggccgtggca ggccagcgtg gccctgggct tccggcacac gtgtgggggc tctgtgctag    900

cgccacgctg ggtggtgact gctgcacatt gtatgcacag tttcaggctg gcccgcctgt    960

ccagctggcg ggttcatgcg gggctggtca gccacagtgc cgtcaggccc caccaagggg   1020

ctctggtgga gaggattatc ccacaccccc tctacagtgc ccagaatcat gactacgacg   1080

tcgccctcct gaggctccag accgctctca acttctcaga cactgtgggc gctgtgtgcc   1140

tgccggccaa ggaacagcat tttccgaagg gctcgcggtg ctgggtgtct ggctggggcc   1200

acacccaccc tagccatact tacagctcgg atatgctcca ggacacggtg gtgcccttgt   1260

tcagcactca gctctgcaac agctcttgcg tgtacagcgg agccctcacc ccccgcatgc   1320

tttgcgctgg ctacctggac ggaagggctg atgcatgcca gggagatagc gggggccccc   1380

tagtgtgccc agatggggac acatggcgcc tagtgggggt ggtcagctgg gggcgtgcgt   1440

gcgcagagcc caatcaccca ggtgtctacg ccaaggtagc tgagtttctg gactggatcc   1500

atgacactgc tcaggactcc ctcctctgag tcctgctgtt tcctccagtc tcactgcaca   1560

ccactgcctc atgcttcctg gggcctccag cagctccact aatggaggag aggcagtagc   1620

ctccgacaca gaacgcatgg acctcctact actgtgtgtg aggaacagtc actacccact   1680

ggccagccac ccagccaaca ggtctctcct cttgggccct gatttcagag tcctctttct   1740

cactagagac tcaatgacag aagagaggct gggacttggt tgggcatgct gtggttgctg   1800

agggatgagg gggaggagag aggtaggagc tggagatgaa gagactgcta gaagcagcag   1860

gaagcctgcc cttctgccct ctcccctccc tgcccctgtg tgagtctttt agggagggtg   1920

actgggaggt gccccccgtc ccaccttttt cctgtgctct aggtgggcta agtgcctccc   1980

tagaggactc catggctgag aggctcctgg gcagatgggg tcaaggctgg gccagtccca   2040

gatgaagcct atgggagtca ggaccctctc cactctccct ctccactccc cttcctgttc   2100

tcacctggct gtggctggcc ctgtgtgggg tgggtacact ggaaaacaag aaggttggag   2160

ttggtctagg acattggttt taaatgacag ttctgtgaac tggtccaagg aggttctgtt   2220

attaaagtga tatatggtct tgaaaaaaaa aaaaaaaaaa aaaaa                   2265


<210>  2887
<211>  457
<212>  PRT
<213>  Homosapiens

<400>  2887

Met Ser Leu Met Leu Asp Asp Gln Pro Pro Met Glu Ala Gln Tyr Ala 
1               5                   10                  15      


Glu Glu Gly Pro Gly Pro Gly Ile Phe Arg Ala Glu Pro Gly Asp Gln 
            20                  25                  30          


Gln His Pro Ile Ser Gln Ala Val Cys Trp Arg Ser Met Arg Arg Gly 
        35                  40                  45              


Cys Ala Val Leu Gly Ala Leu Gly Leu Leu Ala Gly Ala Gly Val Gly 
    50                  55                  60                  


Ser Trp Leu Leu Val Leu Tyr Leu Cys Pro Ala Ala Ser Gln Pro Ile 
65                  70                  75                  80  


Ser Gly Thr Leu Gln Asp Glu Glu Ile Thr Leu Ser Cys Ser Glu Ala 
                85                  90                  95      


Ser Ala Glu Glu Ala Leu Leu Pro Ala Leu Pro Lys Thr Val Ser Phe 
            100                 105                 110         


Arg Ile Asn Ser Glu Asp Phe Leu Leu Glu Ala Gln Val Arg Asp Gln 
        115                 120                 125             


Pro Arg Trp Leu Leu Val Cys His Glu Gly Trp Ser Pro Ala Leu Gly 
    130                 135                 140                 


Leu Gln Ile Cys Trp Ser Leu Gly His Leu Arg Leu Thr His His Lys 
145                 150                 155                 160 


Gly Val Asn Leu Thr Asp Ile Lys Leu Asn Ser Ser Gln Glu Phe Ala 
                165                 170                 175     


Gln Leu Ser Pro Arg Leu Gly Gly Phe Leu Glu Glu Ala Trp Gln Pro 
            180                 185                 190         


Arg Asn Asn Cys Thr Ser Gly Gln Val Val Ser Leu Arg Cys Ser Glu 
        195                 200                 205             


Cys Gly Ala Arg Pro Leu Ala Ser Arg Ile Val Gly Gly Gln Ser Val 
    210                 215                 220                 


Ala Pro Gly Arg Trp Pro Trp Gln Ala Ser Val Ala Leu Gly Phe Arg 
225                 230                 235                 240 


His Thr Cys Gly Gly Ser Val Leu Ala Pro Arg Trp Val Val Thr Ala 
                245                 250                 255     


Ala His Cys Met His Ser Phe Arg Leu Ala Arg Leu Ser Ser Trp Arg 
            260                 265                 270         


Val His Ala Gly Leu Val Ser His Ser Ala Val Arg Pro His Gln Gly 
        275                 280                 285             


Ala Leu Val Glu Arg Ile Ile Pro His Pro Leu Tyr Ser Ala Gln Asn 
    290                 295                 300                 


His Asp Tyr Asp Val Ala Leu Leu Arg Leu Gln Thr Ala Leu Asn Phe 
305                 310                 315                 320 


Ser Asp Thr Val Gly Ala Val Cys Leu Pro Ala Lys Glu Gln His Phe 
                325                 330                 335     


Pro Lys Gly Ser Arg Cys Trp Val Ser Gly Trp Gly His Thr His Pro 
            340                 345                 350         


Ser His Thr Tyr Ser Ser Asp Met Leu Gln Asp Thr Val Val Pro Leu 
        355                 360                 365             


Phe Ser Thr Gln Leu Cys Asn Ser Ser Cys Val Tyr Ser Gly Ala Leu 
    370                 375                 380                 


Thr Pro Arg Met Leu Cys Ala Gly Tyr Leu Asp Gly Arg Ala Asp Ala 
385                 390                 395                 400 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Pro Asp Gly Asp Thr 
                405                 410                 415     


Trp Arg Leu Val Gly Val Val Ser Trp Gly Arg Ala Cys Ala Glu Pro 
            420                 425                 430         


Asn His Pro Gly Val Tyr Ala Lys Val Ala Glu Phe Leu Asp Trp Ile 
        435                 440                 445             


His Asp Thr Ala Gln Asp Ser Leu Leu 
    450                 455         


<210>  2888
<211>  2900
<212>  DNA
<213>  Homosapiens

<400>  2888
gagagtgacc cagtcagcgt tggttcccgt cttggccatg gcctcgttcg tgacagaagt     60

tttggcacac tccgggaggc tggaaaagga ggatctgggg acccggatca gccgcctgac    120

ccggcgggtg gaggagatca agggtgaggt gtgcaatatg attagcaaga agtacagtga    180

attcctgcct agcatgcaga gcgcgcaggg cctgattacc caggtggata agctatctga    240

agacattgac ctgctgaaat ccaggataga gagtgaggtc cgccgggatc ttcacgtatc    300

aaccggtgaa tttacagact taaagcagca gttggaaaga gactcagttg tcctaagttt    360

gcttaaacag ttgcaggagt tttccactgc tattgaagaa tataattgtg cattaacaga    420

gaagaagtat gtcactggtg ctcagcgtct ggaagaggca cagaaatgct tgaagttatt    480

aaaatccaga aaatgctttg atttaaaaat attgaaatct ctcagcatgg agctcacaat    540

acagaaacag aacatacttt atcaccttgg agaagagtgg cagaagctga ttgtatggaa    600

gttcccacca tcaaaagata ccagcagttt ggaatcttac ctacaaactg aacttcattt    660

atacactgaa caatcgcaca aagaggagaa gacccctatg ccacccatca gttctgtcct    720

cttggcattt tctgttcttg gagaactaca cagcaagctt aaatcatttg gtcagatgct    780

gctgaagtat atccttaggc cgctggcatc ttgcccatcc cttcatgctg tgatagaaag    840

ccagcctaac atagttatta ttcgttttga atctataatg actaacttgg aatatccatc    900

accatctgaa gtttttacaa agatcagact ggtactagaa gtgctccaga aacagcttct    960

agatttgcca cttgacactg acctggaaaa tgaaaaaaca tctactgtcc cattggctga   1020

gatgcttgga gacatgatct gggaggactt gtctgagtgc ctcatcaaaa actgtttggt   1080

ttattcgatt ccaacaaata gcagcaaatt acagcaatat gaagagatca tacagtccac   1140

tgaagaattt gaaaatgccc taaaggaaat gagattttta aaaggagata ctacagattt   1200

gctgaaatac gctcgtaaca tcaattctca ttttgcaaac aaaaagtgcc aggatgtgat   1260

tgtggcagcc agaaatctaa tgacctcaga aattcataac actgtgaaga ttattcctga   1320

ttctaagata aatgtgccag agttacccac tcctgatgag gataacaaac tggaagtaca   1380

gaaagtatcc aatactcagt accacgaagt gatgaattta gagcctgaaa atacattgga   1440

ccaacattcc ttttccttgc ccacatgccg tatcagtgag tctgtgaaga aattaatgga   1500

actcgcctat cagactttac tagaggcaac aaccagtagt gatcaatgtg ctgttcaact   1560

tttctactca gtgaggaata tcttccattt gttccatgat gttgtaccaa catatcacaa   1620

ggagaacctt caaaaacttc cccagttggc tgctattcat cacaacaact gtatgtacat   1680

tgctcaccac ttgctgaccc tcgggcatca gttcagattg cgtcttgccc ccattctttg   1740

tgatggcact gctacttttg tggatcttgt acctggcttc aggagacttg ggacagaatg   1800

ctttttggcc caaatgcggg cacagaaagg tgaacttctg gaaagattat caagtgctag   1860

gaacttttca aatatggacg atgaagagaa ttattctgca gcaagtaaag cagtccggca   1920

ggtactgcac caactaaaga gacttggaat tgtgtggcag gatgtcctgc cagtgaatat   1980

atattgcaag gctatgggga ctttactcaa tacagcaatt tctgaggtca ttggcaaaat   2040

tactgcccta gaggacatat ctactgaaga tggtgatagg ttatattcct tatgcaaaac   2100

agtgatggat gaaggacccc aagtatttgc acctttatct gaagaaagca agaacaagaa   2160

atatcaagaa gaggttccag tctatgtgcc aaaatggatg ccattcaagg aattgatgat   2220

gatgctacaa gccagcttgc aagaaattgg ggatcggtgg gcagatggaa aaggacccct   2280

ggcagctgcg ttctcttcca gtgaagtaaa agctttaatt cgtgccttgt ttcagaacac   2340

agaaagaaga gcagctgccc ttgctaaaat taaatagctc catcttctta agaaagctat   2400

gtcttgaata tgtggattct tcccttggca taattactcc cttaaagact tctttgaatc   2460

gcccattggt tttggtgaac cagtacatct tggaagtttg actttacaga agaacgtctt   2520

acctcctggc ctgtacgagg ctttgtttaa gaactgttta ttaagataaa ttgtcaagta   2580

aagcacctca attcattgac tttctagcca tcttcctttg attagctaac aaactgtcag   2640

gcagcattat ttcatgctgc ttccagagcc ctctgggagc tatatacatt gtaaatgcag   2700

gccctagctt tggaacgagg aattgggaga ttccaggagt cagggtagag aatttctgag   2760

caaatcggag atattttagg ggtgtggagg aggggaaggg aggaatgggc caccatattt   2820

ggccttacag gaattaagga gacttcctgt aatatttctt tccaataaat attgcttttt   2880

acaaaaaaaa aaaaaaaaaa                                               2900


<210>  2889
<211>  779
<212>  PRT
<213>  Homosapiens

<400>  2889

Met Ala Ser Phe Val Thr Glu Val Leu Ala His Ser Gly Arg Leu Glu 
1               5                   10                  15      


Lys Glu Asp Leu Gly Thr Arg Ile Ser Arg Leu Thr Arg Arg Val Glu 
            20                  25                  30          


Glu Ile Lys Gly Glu Val Cys Asn Met Ile Ser Lys Lys Tyr Ser Glu 
        35                  40                  45              


Phe Leu Pro Ser Met Gln Ser Ala Gln Gly Leu Ile Thr Gln Val Asp 
    50                  55                  60                  


Lys Leu Ser Glu Asp Ile Asp Leu Leu Lys Ser Arg Ile Glu Ser Glu 
65                  70                  75                  80  


Val Arg Arg Asp Leu His Val Ser Thr Gly Glu Phe Thr Asp Leu Lys 
                85                  90                  95      


Gln Gln Leu Glu Arg Asp Ser Val Val Leu Ser Leu Leu Lys Gln Leu 
            100                 105                 110         


Gln Glu Phe Ser Thr Ala Ile Glu Glu Tyr Asn Cys Ala Leu Thr Glu 
        115                 120                 125             


Lys Lys Tyr Val Thr Gly Ala Gln Arg Leu Glu Glu Ala Gln Lys Cys 
    130                 135                 140                 


Leu Lys Leu Leu Lys Ser Arg Lys Cys Phe Asp Leu Lys Ile Leu Lys 
145                 150                 155                 160 


Ser Leu Ser Met Glu Leu Thr Ile Gln Lys Gln Asn Ile Leu Tyr His 
                165                 170                 175     


Leu Gly Glu Glu Trp Gln Lys Leu Ile Val Trp Lys Phe Pro Pro Ser 
            180                 185                 190         


Lys Asp Thr Ser Ser Leu Glu Ser Tyr Leu Gln Thr Glu Leu His Leu 
        195                 200                 205             


Tyr Thr Glu Gln Ser His Lys Glu Glu Lys Thr Pro Met Pro Pro Ile 
    210                 215                 220                 


Ser Ser Val Leu Leu Ala Phe Ser Val Leu Gly Glu Leu His Ser Lys 
225                 230                 235                 240 


Leu Lys Ser Phe Gly Gln Met Leu Leu Lys Tyr Ile Leu Arg Pro Leu 
                245                 250                 255     


Ala Ser Cys Pro Ser Leu His Ala Val Ile Glu Ser Gln Pro Asn Ile 
            260                 265                 270         


Val Ile Ile Arg Phe Glu Ser Ile Met Thr Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Pro Ser Glu Val Phe Thr Lys Ile Arg Leu Val Leu Glu Val Leu Gln 
    290                 295                 300                 


Lys Gln Leu Leu Asp Leu Pro Leu Asp Thr Asp Leu Glu Asn Glu Lys 
305                 310                 315                 320 


Thr Ser Thr Val Pro Leu Ala Glu Met Leu Gly Asp Met Ile Trp Glu 
                325                 330                 335     


Asp Leu Ser Glu Cys Leu Ile Lys Asn Cys Leu Val Tyr Ser Ile Pro 
            340                 345                 350         


Thr Asn Ser Ser Lys Leu Gln Gln Tyr Glu Glu Ile Ile Gln Ser Thr 
        355                 360                 365             


Glu Glu Phe Glu Asn Ala Leu Lys Glu Met Arg Phe Leu Lys Gly Asp 
    370                 375                 380                 


Thr Thr Asp Leu Leu Lys Tyr Ala Arg Asn Ile Asn Ser His Phe Ala 
385                 390                 395                 400 


Asn Lys Lys Cys Gln Asp Val Ile Val Ala Ala Arg Asn Leu Met Thr 
                405                 410                 415     


Ser Glu Ile His Asn Thr Val Lys Ile Ile Pro Asp Ser Lys Ile Asn 
            420                 425                 430         


Val Pro Glu Leu Pro Thr Pro Asp Glu Asp Asn Lys Leu Glu Val Gln 
        435                 440                 445             


Lys Val Ser Asn Thr Gln Tyr His Glu Val Met Asn Leu Glu Pro Glu 
    450                 455                 460                 


Asn Thr Leu Asp Gln His Ser Phe Ser Leu Pro Thr Cys Arg Ile Ser 
465                 470                 475                 480 


Glu Ser Val Lys Lys Leu Met Glu Leu Ala Tyr Gln Thr Leu Leu Glu 
                485                 490                 495     


Ala Thr Thr Ser Ser Asp Gln Cys Ala Val Gln Leu Phe Tyr Ser Val 
            500                 505                 510         


Arg Asn Ile Phe His Leu Phe His Asp Val Val Pro Thr Tyr His Lys 
        515                 520                 525             


Glu Asn Leu Gln Lys Leu Pro Gln Leu Ala Ala Ile His His Asn Asn 
    530                 535                 540                 


Cys Met Tyr Ile Ala His His Leu Leu Thr Leu Gly His Gln Phe Arg 
545                 550                 555                 560 


Leu Arg Leu Ala Pro Ile Leu Cys Asp Gly Thr Ala Thr Phe Val Asp 
                565                 570                 575     


Leu Val Pro Gly Phe Arg Arg Leu Gly Thr Glu Cys Phe Leu Ala Gln 
            580                 585                 590         


Met Arg Ala Gln Lys Gly Glu Leu Leu Glu Arg Leu Ser Ser Ala Arg 
        595                 600                 605             


Asn Phe Ser Asn Met Asp Asp Glu Glu Asn Tyr Ser Ala Ala Ser Lys 
    610                 615                 620                 


Ala Val Arg Gln Val Leu His Gln Leu Lys Arg Leu Gly Ile Val Trp 
625                 630                 635                 640 


Gln Asp Val Leu Pro Val Asn Ile Tyr Cys Lys Ala Met Gly Thr Leu 
                645                 650                 655     


Leu Asn Thr Ala Ile Ser Glu Val Ile Gly Lys Ile Thr Ala Leu Glu 
            660                 665                 670         


Asp Ile Ser Thr Glu Asp Gly Asp Arg Leu Tyr Ser Leu Cys Lys Thr 
        675                 680                 685             


Val Met Asp Glu Gly Pro Gln Val Phe Ala Pro Leu Ser Glu Glu Ser 
    690                 695                 700                 


Lys Asn Lys Lys Tyr Gln Glu Glu Val Pro Val Tyr Val Pro Lys Trp 
705                 710                 715                 720 


Met Pro Phe Lys Glu Leu Met Met Met Leu Gln Ala Ser Leu Gln Glu 
                725                 730                 735     


Ile Gly Asp Arg Trp Ala Asp Gly Lys Gly Pro Leu Ala Ala Ala Phe 
            740                 745                 750         


Ser Ser Ser Glu Val Lys Ala Leu Ile Arg Ala Leu Phe Gln Asn Thr 
        755                 760                 765             


Glu Arg Arg Ala Ala Ala Leu Ala Lys Ile Lys 
    770                 775                 


<210>  2890
<211>  4642
<212>  DNA
<213>  Homosapiens

<400>  2890
gagaccggtg acccgcggct gggcgcctcg gccatgactg cggagctgca gcaggacgac     60

gcggccggcg cggcagacgg ccacggctcg agctgccaaa tgctgttaaa tcaactgaga    120

gaaatcacag gcattcagga cccttccttt ctccatgaag ctctgaaggc cagtaatggt    180

gacattactc aggcagtcag ccttctcact gatgagagag ttaaggagcc cagtcaagac    240

actgttgcta cagaaccatc tgaagtagag gggagtgctg ccaacaagga agtattagca    300

aaagttatag accttactca tgataacaaa gatgatcttc aggctgccat tgctttgagt    360

ctactggagt ctcccaaaat tcaagctgat ggaagagatc ttaacaggat gcatgaagca    420

acctctgcag aaactaaacg ctcaaagaga aaacgctgtg aagtctgggg agaaaacccc    480

aatcccaatg actggaggag agttgatggt tggccagttg ggctgaaaaa tgttggcaat    540

acatgttggt ttagtgctgt tattcagtct ctctttcaat tgcctgaatt tcgaagactt    600

gttctcagtt atagtctgcc acaaaatgta cttgaaaatt gtcgaagtca tacagaaaag    660

agaaatatca tgtttatgca agagcttcag tatttgtttg ctctaatgat gggatcaaat    720

agaaaatttg tagacccgtc tgcagccctg gatctattaa agggagcatt ccgatcatct    780

gaggaacagc agcaagatgt gagtgaattc acacacaagc tcctggattg gctagaggac    840

gcattccagc tagctgttaa tgttaacagt cccaggaaca aatctgaaaa tccaatggtg    900

cagctgttct atggtacttt cctgactgaa ggggttcgtg aaggaaaacc cttttgtaac    960

aatgagacct tcggccagta tcctcttcag gtaaacggtt atcgcaactt agacgagtgt   1020

ttggaagggg ccatggtgga gggtgatgtt gagcttcttc cctccgatca ctcggtgaag   1080

tatggacaag agcgttggtt tacaaagcta cctccagtgt tgacctttga actctcaaga   1140

tttgagttta atcagtccct tgggcagcca gagaaaattc acaataagct ggaatttcct   1200

cagattattt atatggacag gtacatgtac aggagcaagg agcttattcg aaataagaga   1260

gagtgtattc gaaagttgaa ggaggaaata aaaattctgc agcaaaaatt ggaaaggtat   1320

gtgaaatatg gctcaggccc agctcggttc ccgctcccgg acatgctgaa atatgttatt   1380

gaatttgcta gtacaaaacc tgcctcagaa agctgtccac ctgaaagtga cacacatatg   1440

acattaccac tttcttcagt gcactgctcg gtttctgacc agacatccaa ggaaagtaca   1500

agtacagaaa gctcttctca ggatgttgaa agtacctttt cttctcctga agattcttta   1560

cccaagtcta aaccactgac atcttctcgg tcttccatgg aaatgccttc acagccagct   1620

ccacgaacag tcacagatga ggagataaat tttgttaaga cctgtcttca gagatggagg   1680

agtgagattg aacaagatat acaagattta aagacttgta ttgcaagtac tactcagact   1740

attgaacaga tgtactgcga tcctctcctt cgtcaggtgc cttatcgctt gcatgcagtt   1800

cttgttcatg aaggacaagc aaatgctgga cactattggg cctatatcta taatcaaccc   1860

cgacagagct ggctcaagta caatgacatc tctgttactg aatcttcctg ggaagaagtt   1920

gaaagagatt cctatggagg cctgagaaat gttagtgctt actgtctgat gtacattaat   1980

gacaaactac cctacttcaa tgcagaggca gccccaactg aatcagatca aatgtcagaa   2040

gtggaagccc tatctgtgga actcaagcat tacattcagg aggataactg gcggtttgag   2100

caggaagtag aggagtggga agaagagcag tcttgcaaaa tccctcaaat ggagtcctcc   2160

accaactcct catcacagga ctactctaca tcacaagagc cttcagtagc ctcttctcat   2220

ggggttcgct gcttgtcgtc tgagcatgct gtgattgtaa aggagcaaac tgcccaggct   2280

attgcaaaca cagcccgtgc ctatgagaag agcggtgtag aagcggcact gagtgaggtg   2340

atgctgagcc ctgccatgca aggggtcatc ctggccatag ctaaagcccg tcagaccttt   2400

gaccgagatg ggtctgaagc agggctgatt aaggcattcc atgaagaata ctccaggctc   2460

tatcagcttg ccaaagagac ccccacctct cacagtgatc ctcgacttca gcatgtcctt   2520

gtctactttt tccaaaatga agcacccaaa agggtagtag aacgaaccct tctggaacag   2580

tttgcagata aaaatcttag ctatgatgaa agatcaatca gcattatgaa ggtggctcaa   2640

gcgaaactga aggaaattgg tccagatgac atgaatatgg aagagtacaa gaagtggcat   2700

gaagattata gtttgttccg aaaagtgtct gtgtatctcc taacaggcct agaactctat   2760

caaaaaggaa agtaccaaga ggcactttcc tacctggtat atgcctacca gagcaatgct   2820

gccctgctga tgaaggggcc ccgccggggg gtcaaagaat ccgtgattgc tttataccga   2880

agaaaatgcc ttctggagct gaatgccaaa gcagcttctc tttttgaaac aaatgatgat   2940

cactccgtaa ctgagggcat taatgtgatg aatgaactga tcatcccctg cattcacctt   3000

atcattaata atgacatttc caaggatgat ctggatgcca ttgaggtcat gagaaaccat   3060

tggtgctctt accttgggca agatattgca gaaaatctgc agctgtgcct aggggagttt   3120

ctacccagac ttctagatcc ttctgcagaa atcatcgtct tgaaagagcc tccaactatt   3180

cgacccaatt ctccctatga cctatgtagc cgatttgcag ctgtcatgga gtcaattcag   3240

ggagtttcaa ctgtgacagt gaaataagct cccacatgtt caaggcccat tctggttcct   3300

ggctgcctgc ctcttgcaca gaagttcgtt gtcatagtgc tcaccttggg aaaaggatta   3360

ggtgggcaca taagattccg atcagacccc aaccatgctg catgtgtaaa gaaggattga   3420

aaataaaatt gcacttttta ggtacaaaat cataaaagct gtttcactag aaaaggcaga   3480

aagcagtgta ttaaggtgtt gaattacgcc agaagacctg aaatgccttg tacctacaac   3540

aatgcttagg cttttctaag cctcttgcca cttttaaaat tatccttcag gcataaatat   3600

ttttgacagc agaatagaag aatgattcat gagaacctga accagatgaa cagctactag   3660

ttattttatc aaatacagat gacatttaaa aattcttaac tacaagagat tagaaatata   3720

aaccttgcct ggctcttgcc aggagataac aaaatgggtt gctgatgaac tgcacccttt   3780

tacatgtggg tagaatataa gctcacatgg cagtgagatg ttgaaaagtc aaaagagacc   3840

tgtctctctc ctttcttttc tatctttaaa ccagaaaacc tcatactcag tcctcagtga   3900

aagaaagtaa agtattaagg actttagaca gaagagcatt gtgtaacttg actgaagatc   3960

atccattaat agttattagg catttaggta aaattttcta atacctaaaa attgtcaaaa   4020

acagtcaata gggctactgc tggcccaaag accatttagg tccacctcct cttttttgct   4080

cttttttttt ttctgtgaca gtttcactgt gtcgcccagg ctggcgttca gtggtgcaat   4140

ctcagctcac tgcaaactct gtctcctggg ctcaagtgat tctcgtgcct cagcctcccg   4200

aatagctgga attacgggca tgcaccacca cacctggcta atttttgtat ttttaataga   4260

gatggggttt caccatattg gccaggctga tctctaactc ctggcctcaa gtgatctatc   4320

tgcctccctc agcctcccaa agtctgggat tgcagacaag tcatcgtacc cggccttctt   4380

ttttgccctt aaaagtaagg gatgtgggtt tgtacaaaaa aaaaaaaaaa aaaaaaaaaa   4440

ccagcataca tatgcaaaac tatatatata tgtatatgta gagaaaaata cttcccattg   4500

atcattttta aaaggcttct gattggatat tgtgttttaa ccaaatttta aagattaatg   4560

gaatcatgaa agggaaaaaa attgatacaa ctatgcagat tttataaatg tgcaataaaa   4620

gtatttgttt taaaaaaaaa aa                                            4642


<210>  2891
<211>  1077
<212>  PRT
<213>  Homosapiens

<400>  2891

Met Thr Ala Glu Leu Gln Gln Asp Asp Ala Ala Gly Ala Ala Asp Gly 
1               5                   10                  15      


His Gly Ser Ser Cys Gln Met Leu Leu Asn Gln Leu Arg Glu Ile Thr 
            20                  25                  30          


Gly Ile Gln Asp Pro Ser Phe Leu His Glu Ala Leu Lys Ala Ser Asn 
        35                  40                  45              


Gly Asp Ile Thr Gln Ala Val Ser Leu Leu Thr Asp Glu Arg Val Lys 
    50                  55                  60                  


Glu Pro Ser Gln Asp Thr Val Ala Thr Glu Pro Ser Glu Val Glu Gly 
65                  70                  75                  80  


Ser Ala Ala Asn Lys Glu Val Leu Ala Lys Val Ile Asp Leu Thr His 
                85                  90                  95      


Asp Asn Lys Asp Asp Leu Gln Ala Ala Ile Ala Leu Ser Leu Leu Glu 
            100                 105                 110         


Ser Pro Lys Ile Gln Ala Asp Gly Arg Asp Leu Asn Arg Met His Glu 
        115                 120                 125             


Ala Thr Ser Ala Glu Thr Lys Arg Ser Lys Arg Lys Arg Cys Glu Val 
    130                 135                 140                 


Trp Gly Glu Asn Pro Asn Pro Asn Asp Trp Arg Arg Val Asp Gly Trp 
145                 150                 155                 160 


Pro Val Gly Leu Lys Asn Val Gly Asn Thr Cys Trp Phe Ser Ala Val 
                165                 170                 175     


Ile Gln Ser Leu Phe Gln Leu Pro Glu Phe Arg Arg Leu Val Leu Ser 
            180                 185                 190         


Tyr Ser Leu Pro Gln Asn Val Leu Glu Asn Cys Arg Ser His Thr Glu 
        195                 200                 205             


Lys Arg Asn Ile Met Phe Met Gln Glu Leu Gln Tyr Leu Phe Ala Leu 
    210                 215                 220                 


Met Met Gly Ser Asn Arg Lys Phe Val Asp Pro Ser Ala Ala Leu Asp 
225                 230                 235                 240 


Leu Leu Lys Gly Ala Phe Arg Ser Ser Glu Glu Gln Gln Gln Asp Val 
                245                 250                 255     


Ser Glu Phe Thr His Lys Leu Leu Asp Trp Leu Glu Asp Ala Phe Gln 
            260                 265                 270         


Leu Ala Val Asn Val Asn Ser Pro Arg Asn Lys Ser Glu Asn Pro Met 
        275                 280                 285             


Val Gln Leu Phe Tyr Gly Thr Phe Leu Thr Glu Gly Val Arg Glu Gly 
    290                 295                 300                 


Lys Pro Phe Cys Asn Asn Glu Thr Phe Gly Gln Tyr Pro Leu Gln Val 
305                 310                 315                 320 


Asn Gly Tyr Arg Asn Leu Asp Glu Cys Leu Glu Gly Ala Met Val Glu 
                325                 330                 335     


Gly Asp Val Glu Leu Leu Pro Ser Asp His Ser Val Lys Tyr Gly Gln 
            340                 345                 350         


Glu Arg Trp Phe Thr Lys Leu Pro Pro Val Leu Thr Phe Glu Leu Ser 
        355                 360                 365             


Arg Phe Glu Phe Asn Gln Ser Leu Gly Gln Pro Glu Lys Ile His Asn 
    370                 375                 380                 


Lys Leu Glu Phe Pro Gln Ile Ile Tyr Met Asp Arg Tyr Met Tyr Arg 
385                 390                 395                 400 


Ser Lys Glu Leu Ile Arg Asn Lys Arg Glu Cys Ile Arg Lys Leu Lys 
                405                 410                 415     


Glu Glu Ile Lys Ile Leu Gln Gln Lys Leu Glu Arg Tyr Val Lys Tyr 
            420                 425                 430         


Gly Ser Gly Pro Ala Arg Phe Pro Leu Pro Asp Met Leu Lys Tyr Val 
        435                 440                 445             


Ile Glu Phe Ala Ser Thr Lys Pro Ala Ser Glu Ser Cys Pro Pro Glu 
    450                 455                 460                 


Ser Asp Thr His Met Thr Leu Pro Leu Ser Ser Val His Cys Ser Val 
465                 470                 475                 480 


Ser Asp Gln Thr Ser Lys Glu Ser Thr Ser Thr Glu Ser Ser Ser Gln 
                485                 490                 495     


Asp Val Glu Ser Thr Phe Ser Ser Pro Glu Asp Ser Leu Pro Lys Ser 
            500                 505                 510         


Lys Pro Leu Thr Ser Ser Arg Ser Ser Met Glu Met Pro Ser Gln Pro 
        515                 520                 525             


Ala Pro Arg Thr Val Thr Asp Glu Glu Ile Asn Phe Val Lys Thr Cys 
    530                 535                 540                 


Leu Gln Arg Trp Arg Ser Glu Ile Glu Gln Asp Ile Gln Asp Leu Lys 
545                 550                 555                 560 


Thr Cys Ile Ala Ser Thr Thr Gln Thr Ile Glu Gln Met Tyr Cys Asp 
                565                 570                 575     


Pro Leu Leu Arg Gln Val Pro Tyr Arg Leu His Ala Val Leu Val His 
            580                 585                 590         


Glu Gly Gln Ala Asn Ala Gly His Tyr Trp Ala Tyr Ile Tyr Asn Gln 
        595                 600                 605             


Pro Arg Gln Ser Trp Leu Lys Tyr Asn Asp Ile Ser Val Thr Glu Ser 
    610                 615                 620                 


Ser Trp Glu Glu Val Glu Arg Asp Ser Tyr Gly Gly Leu Arg Asn Val 
625                 630                 635                 640 


Ser Ala Tyr Cys Leu Met Tyr Ile Asn Asp Lys Leu Pro Tyr Phe Asn 
                645                 650                 655     


Ala Glu Ala Ala Pro Thr Glu Ser Asp Gln Met Ser Glu Val Glu Ala 
            660                 665                 670         


Leu Ser Val Glu Leu Lys His Tyr Ile Gln Glu Asp Asn Trp Arg Phe 
        675                 680                 685             


Glu Gln Glu Val Glu Glu Trp Glu Glu Glu Gln Ser Cys Lys Ile Pro 
    690                 695                 700                 


Gln Met Glu Ser Ser Thr Asn Ser Ser Ser Gln Asp Tyr Ser Thr Ser 
705                 710                 715                 720 


Gln Glu Pro Ser Val Ala Ser Ser His Gly Val Arg Cys Leu Ser Ser 
                725                 730                 735     


Glu His Ala Val Ile Val Lys Glu Gln Thr Ala Gln Ala Ile Ala Asn 
            740                 745                 750         


Thr Ala Arg Ala Tyr Glu Lys Ser Gly Val Glu Ala Ala Leu Ser Glu 
        755                 760                 765             


Val Met Leu Ser Pro Ala Met Gln Gly Val Ile Leu Ala Ile Ala Lys 
    770                 775                 780                 


Ala Arg Gln Thr Phe Asp Arg Asp Gly Ser Glu Ala Gly Leu Ile Lys 
785                 790                 795                 800 


Ala Phe His Glu Glu Tyr Ser Arg Leu Tyr Gln Leu Ala Lys Glu Thr 
                805                 810                 815     


Pro Thr Ser His Ser Asp Pro Arg Leu Gln His Val Leu Val Tyr Phe 
            820                 825                 830         


Phe Gln Asn Glu Ala Pro Lys Arg Val Val Glu Arg Thr Leu Leu Glu 
        835                 840                 845             


Gln Phe Ala Asp Lys Asn Leu Ser Tyr Asp Glu Arg Ser Ile Ser Ile 
    850                 855                 860                 


Met Lys Val Ala Gln Ala Lys Leu Lys Glu Ile Gly Pro Asp Asp Met 
865                 870                 875                 880 


Asn Met Glu Glu Tyr Lys Lys Trp His Glu Asp Tyr Ser Leu Phe Arg 
                885                 890                 895     


Lys Val Ser Val Tyr Leu Leu Thr Gly Leu Glu Leu Tyr Gln Lys Gly 
            900                 905                 910         


Lys Tyr Gln Glu Ala Leu Ser Tyr Leu Val Tyr Ala Tyr Gln Ser Asn 
        915                 920                 925             


Ala Ala Leu Leu Met Lys Gly Pro Arg Arg Gly Val Lys Glu Ser Val 
    930                 935                 940                 


Ile Ala Leu Tyr Arg Arg Lys Cys Leu Leu Glu Leu Asn Ala Lys Ala 
945                 950                 955                 960 


Ala Ser Leu Phe Glu Thr Asn Asp Asp His Ser Val Thr Glu Gly Ile 
                965                 970                 975     


Asn Val Met Asn Glu Leu Ile Ile Pro Cys Ile His Leu Ile Ile Asn 
            980                 985                 990         


Asn Asp Ile Ser Lys Asp Asp Leu  Asp Ala Ile Glu Val  Met Arg Asn 
        995                 1000                 1005             


His Trp  Cys Ser Tyr Leu Gly  Gln Asp Ile Ala Glu  Asn Leu Gln 
    1010                 1015                 1020             


Leu Cys  Leu Gly Glu Phe Leu  Pro Arg Leu Leu Asp  Pro Ser Ala 
    1025                 1030                 1035             


Glu Ile  Ile Val Leu Lys Glu  Pro Pro Thr Ile Arg  Pro Asn Ser 
    1040                 1045                 1050             


Pro Tyr  Asp Leu Cys Ser Arg  Phe Ala Ala Val Met  Glu Ser Ile 
    1055                 1060                 1065             


Gln Gly  Val Ser Thr Val Thr  Val Lys 
    1070                 1075         


<210>  2892
<211>  1847
<212>  DNA
<213>  Homosapiens

<400>  2892
gagaaattga gcggcattcc atctggtagg caagtttgca tttctccttt ttgggatctg     60

cccaggaatg ttgtcaagtg taatggctcc cctgtgggcc tgcatcctgg tggctgcagg    120

aattctagcc acagatacac atcatcccca ggattctgct ctgtatcatc tcagcaagca    180

gctattacag aaatatcata aagaagtgag acctgtttac aactggacca aggccaccac    240

agtctacctg gacctgttcg tccatgctat attggatgtg gatgcagaga atcaaatatt    300

aaagacaagt gtatggtacc aagaggtctg gaatgatgaa tttttatcct ggaactccag    360

catgtttgat gagattagag agatctccct acctctaagt gccatctggg cccccgatat    420

catcatcaat gagtttgtgg acattgaaag ataccctgac cttccctatg tttatgtgaa    480

ctcatctggg accattgaga actataagcc catccaggtg gtctctgcgt gcagtttaga    540

gacatatgct tttccatttg atgtccagaa ttgcagcctg accttcaaga gcattctgca    600

tacagtggaa gacgtagacc tggcctttct gaggagccca gaagacattc agcatgacaa    660

aaaggcgttt ttgaatgaca gtgagtggga acttctatct gtgtcctcca catacagcat    720

cctgcagagc agcgctggag gatttgcaca gattcagttt aatgtggtga tgcgcaggca    780

ccccctggtc tatgtcgtga gtctgctgat tcctagcatc tttctcatgc tggtggacct    840

ggggagcttc tacctgccac ccaactgccg agccaggatt gtgttcaaga ccagtgtgct    900

ggtgggctac accgtcttca gggtcaacat gtccaaccag gtgccacgga gtgtagggag    960

cacccctctg attgggcact tcttcaccat ctgcatggcc ttcttggttc tcagcttagc   1020

taagtccatc gtgttggtca aattcctcca tgatgagcag cgtggtggac aggagcagcc   1080

cttcttgtgc cttcgagggg acaccgatgc tgacaggcct agagtggaac ccagggccca   1140

acgtgctgtg gtaacagagt cctcgctgta tggagagcac ctggcccagc caggaaccct   1200

gaaggaagtc tggtcgcagc ttcaatctat cagcaactac ctccaaactc aggaccagac   1260

agaccaacag gaggcagagt ggctggtcct cctgtcccgc tttgaccgac tgctcttcca   1320

aagctacctt ttcatgctgg ggatctacac catcactctg tgctccctct gggcactgtg   1380

gggcggcgtg tgaagactga agtgttcttc agtaattgtg ctggcactta ggagagagag   1440

gagggggaat aatagtgggt taaaaagctt tctgggtcgg gtgtggtggt tcttgcctat   1500

agtcccagtg ctttgggagg ccatagcagg aggattgctt gagcccagga gttcgagacc   1560

agccagagca acatagtgag accacatctc taccagtaaa taaataaata aataaataaa   1620

taaataaata aataaatagc tgggcatagt ggctcatgcc tgtactctca gctacttggg   1680

aggttgaggt gggaggattg cttgagccca ggatttcaag gctgcagtga gccatgattg   1740

caccactgca ccccagcctg ggtgacagag caagaccctg tctcaaaaaa aataaaataa   1800

aaggctttct gccttcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 1847


<210>  2893
<211>  441
<212>  PRT
<213>  Homosapiens

<400>  2893

Met Leu Ser Ser Val Met Ala Pro Leu Trp Ala Cys Ile Leu Val Ala 
1               5                   10                  15      


Ala Gly Ile Leu Ala Thr Asp Thr His His Pro Gln Asp Ser Ala Leu 
            20                  25                  30          


Tyr His Leu Ser Lys Gln Leu Leu Gln Lys Tyr His Lys Glu Val Arg 
        35                  40                  45              


Pro Val Tyr Asn Trp Thr Lys Ala Thr Thr Val Tyr Leu Asp Leu Phe 
    50                  55                  60                  


Val His Ala Ile Leu Asp Val Asp Ala Glu Asn Gln Ile Leu Lys Thr 
65                  70                  75                  80  


Ser Val Trp Tyr Gln Glu Val Trp Asn Asp Glu Phe Leu Ser Trp Asn 
                85                  90                  95      


Ser Ser Met Phe Asp Glu Ile Arg Glu Ile Ser Leu Pro Leu Ser Ala 
            100                 105                 110         


Ile Trp Ala Pro Asp Ile Ile Ile Asn Glu Phe Val Asp Ile Glu Arg 
        115                 120                 125             


Tyr Pro Asp Leu Pro Tyr Val Tyr Val Asn Ser Ser Gly Thr Ile Glu 
    130                 135                 140                 


Asn Tyr Lys Pro Ile Gln Val Val Ser Ala Cys Ser Leu Glu Thr Tyr 
145                 150                 155                 160 


Ala Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Lys Ser Ile 
                165                 170                 175     


Leu His Thr Val Glu Asp Val Asp Leu Ala Phe Leu Arg Ser Pro Glu 
            180                 185                 190         


Asp Ile Gln His Asp Lys Lys Ala Phe Leu Asn Asp Ser Glu Trp Glu 
        195                 200                 205             


Leu Leu Ser Val Ser Ser Thr Tyr Ser Ile Leu Gln Ser Ser Ala Gly 
    210                 215                 220                 


Gly Phe Ala Gln Ile Gln Phe Asn Val Val Met Arg Arg His Pro Leu 
225                 230                 235                 240 


Val Tyr Val Val Ser Leu Leu Ile Pro Ser Ile Phe Leu Met Leu Val 
                245                 250                 255     


Asp Leu Gly Ser Phe Tyr Leu Pro Pro Asn Cys Arg Ala Arg Ile Val 
            260                 265                 270         


Phe Lys Thr Ser Val Leu Val Gly Tyr Thr Val Phe Arg Val Asn Met 
        275                 280                 285             


Ser Asn Gln Val Pro Arg Ser Val Gly Ser Thr Pro Leu Ile Gly His 
    290                 295                 300                 


Phe Phe Thr Ile Cys Met Ala Phe Leu Val Leu Ser Leu Ala Lys Ser 
305                 310                 315                 320 


Ile Val Leu Val Lys Phe Leu His Asp Glu Gln Arg Gly Gly Gln Glu 
                325                 330                 335     


Gln Pro Phe Leu Cys Leu Arg Gly Asp Thr Asp Ala Asp Arg Pro Arg 
            340                 345                 350         


Val Glu Pro Arg Ala Gln Arg Ala Val Val Thr Glu Ser Ser Leu Tyr 
        355                 360                 365             


Gly Glu His Leu Ala Gln Pro Gly Thr Leu Lys Glu Val Trp Ser Gln 
    370                 375                 380                 


Leu Gln Ser Ile Ser Asn Tyr Leu Gln Thr Gln Asp Gln Thr Asp Gln 
385                 390                 395                 400 


Gln Glu Ala Glu Trp Leu Val Leu Leu Ser Arg Phe Asp Arg Leu Leu 
                405                 410                 415     


Phe Gln Ser Tyr Leu Phe Met Leu Gly Ile Tyr Thr Ile Thr Leu Cys 
            420                 425                 430         


Ser Leu Trp Ala Leu Trp Gly Gly Val 
        435                 440     


<210>  2894
<211>  2147
<212>  DNA
<213>  Homosapiens

<400>  2894
gcagcctcag aaggtgtgag cagtggccac gagaggcagg ctggctggga catgaggttg     60

gcagagggca ggcaagctgg cccttggtgg gcctcgtcct gagcactcgg aggcactcct    120

atgcttggaa agctcgctat gctgctgtgg gtccagcagg cgctgctcgc cttgctcctc    180

cccacactcc tggcacaggg agaagccagg aggagccgaa acaccaccag gcccgctctg    240

ctgaggctgt cggattacct tttgaccaac tacaggaagg gtgtgcgccc cgtgagggac    300

tggaggaagc caaccaccgt atccattgac gtcattgtct atgccatcct caacgtggat    360

gagaagaatc aggtgctgac cacctacatc tggtaccggc agtactggac tgatgagttt    420

ctccagtgga accctgagga ctttgacaac atcaccaagt tgtccatccc cacggacagc    480

atctgggtcc cggacattct catcaatgag ttcgtggatg tggggaagtc tccaaatatc    540

ccgtacgtgt atattcggca tcaaggcgaa gttcagaact acaagcccct tcaggtggtg    600

actgcctgta gcctcgacat ctacaacttc cccttcgatg tccagaactg ctcgctgacc    660

ttcaccagtt ggctgcacac catccaggac atcaacatct ctttgtggcg cttgccagaa    720

aaggtgaaat ccgacaggag tgtcttcatg aaccagggag agtgggagtt gctgggggtg    780

ctgccctact ttcgggagtt cagcatggaa agcagtaact actatgcaga aatgaagttc    840

tatgtggtca tccgccggcg gcccctcttc tatgtggtca gcctgctact gcccagcatc    900

ttcctcatgg tcatggacat cgtgggcttc tacctgcccc ccaacagtgg cgagagggtc    960

tctttcaaga ttacactcct cctgggctac tcggtcttcc tgatcatcgt ttctgacacg   1020

ctgccggcca ctgccatcgg cactcctctc attggtgtct actttgtggt gtgcatggct   1080

ctgctggtga taagtttggc cgagaccatc ttcattgtgc ggctggtgca caagcaagac   1140

ctgcagcagc ccgtgcctgc ttggctgcgt cacctggttc tggagagaat cgcctggcta   1200

ctttgcctga gggagcagtc aacttcccag aggcccccag ccacctccca agccaccaag   1260

actgatgact gctcagccat gggaaaccac tgcagccaca tgggaggacc ccaggacttc   1320

gagaagagcc cgagggacag atgtagccct cccccaccac ctcgggaggc ctcgctggcg   1380

gtgtgtgggc tgctgcagga gctgtcctcc atccggcaat tcctggaaaa gcgggatgag   1440

atccgagagg tggcccgaga ctggctgcgc gtgggctccg tgctggacaa gctgctattc   1500

cacatttacc tgctagcggt gctggcctac agcatcaccc tggttatgct ctggtccatc   1560

tggcagtacg cttgagtggg tacagcccag tggaggaggg ggtacagtcc tggttaggtg   1620

gggacagagg atttctgctt aggcccctca ggacccaggg aatgccaggg acattttcaa   1680

gacacagaca aagtcccgtg ccctgtttcc aatgccaatt catctcagca atcacaagcc   1740

aaggtctgaa cccttccacc aaaaactggg tgttcaaggc ccttacaccc ttgtcccacc   1800

cccagcagct caccatggct ttaaaacatg ctctcttaga tcaggagaaa ctcgggcact   1860

ccctaagtcc actctagttg tggacttttc cccattgacc ctcacctgaa taagggactt   1920

tggaattctg cttctctttc acaactttgc ttttaggttg aaggcaaaac caactctcta   1980

ctacacaggc ctgataactc tgtacgaggc ttctctaacc cctagtgtct tttttttctt   2040

cacctcactt gtggcagctt ccctgaacac tcatccccca tcagatgatg ggagtgggaa   2100

gaataaaatg cagtgaaacc ctaaaaaaaa aaaaaaaaaa aaaaaaa                 2147


<210>  2895
<211>  478
<212>  PRT
<213>  Homosapiens

<400>  2895

Met Leu Leu Trp Val Gln Gln Ala Leu Leu Ala Leu Leu Leu Pro Thr 
1               5                   10                  15      


Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser Arg Asn Thr Thr Arg Pro 
            20                  25                  30          


Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu Thr Asn Tyr Arg Lys Gly 
        35                  40                  45              


Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr Thr Val Ser Ile Asp 
    50                  55                  60                  


Val Ile Val Tyr Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val Leu 
65                  70                  75                  80  


Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp Thr Asp Glu Phe Leu Gln 
                85                  90                  95      


Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr Lys Leu Ser Ile Pro Thr 
            100                 105                 110         


Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn Glu Phe Val Asp Val 
        115                 120                 125             


Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr Ile Arg His Gln Gly Glu 
    130                 135                 140                 


Val Gln Asn Tyr Lys Pro Leu Gln Val Val Thr Ala Cys Ser Leu Asp 
145                 150                 155                 160 


Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Thr 
                165                 170                 175     


Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile Ser Leu Trp Arg Leu 
            180                 185                 190         


Pro Glu Lys Val Lys Ser Asp Arg Ser Val Phe Met Asn Gln Gly Glu 
        195                 200                 205             


Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe Arg Glu Phe Ser Met Glu 
    210                 215                 220                 


Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe Tyr Val Val Ile Arg Arg 
225                 230                 235                 240 


Arg Pro Leu Phe Tyr Val Val Ser Leu Leu Leu Pro Ser Ile Phe Leu 
                245                 250                 255     


Met Val Met Asp Ile Val Gly Phe Tyr Leu Pro Pro Asn Ser Gly Glu 
            260                 265                 270         


Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly Tyr Ser Val Phe Leu 
        275                 280                 285             


Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala Ile Gly Thr Pro Leu 
    290                 295                 300                 


Ile Gly Val Tyr Phe Val Val Cys Met Ala Leu Leu Val Ile Ser Leu 
305                 310                 315                 320 


Ala Glu Thr Ile Phe Ile Val Arg Leu Val His Lys Gln Asp Leu Gln 
                325                 330                 335     


Gln Pro Val Pro Ala Trp Leu Arg His Leu Val Leu Glu Arg Ile Ala 
            340                 345                 350         


Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr Ser Gln Arg Pro Pro Ala 
        355                 360                 365             


Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys Ser Ala Met Gly Asn His 
    370                 375                 380                 


Cys Ser His Met Gly Gly Pro Gln Asp Phe Glu Lys Ser Pro Arg Asp 
385                 390                 395                 400 


Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu Ala Ser Leu Ala Val Cys 
                405                 410                 415     


Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg Gln Phe Leu Glu Lys Arg 
            420                 425                 430         


Asp Glu Ile Arg Glu Val Ala Arg Asp Trp Leu Arg Val Gly Ser Val 
        435                 440                 445             


Leu Asp Lys Leu Leu Phe His Ile Tyr Leu Leu Ala Val Leu Ala Tyr 
    450                 455                 460                 


Ser Ile Thr Leu Val Met Leu Trp Ser Ile Trp Gln Tyr Ala 
465                 470                 475             


<210>  2896
<211>  2243
<212>  DNA
<213>  Homosapiens

<400>  2896
gcagcctcag aaggtgtgag cagtggccac gagaggcagg ctggctggga catgaggttg     60

gcagagggca ggcaagctgg cccttggtgg gcctcgtcct gagcactcgg aggcactcct    120

atgcttggaa agctcgctat gctgctgtgg gtccagcagg cgctgctcgc cttgctcctc    180

cccacactcc tggcacaggg agaagccagg aggagccgaa acaccaccag gcccgctctg    240

ctgaggctgt cggattacct tttgaccaac tacaggaagg gtgtgcgccc cgtgagggac    300

tggaggaagc caaccaccgt atccattgac gtcattgtct atgccatcct caacgtggat    360

gagaagaatc aggtgctgac cacctacatc tggtaccggc agtactggac tgatgagttt    420

ctccagtgga accctgagga ctttgacaac atcaccaagt tgtccatccc cacggacagc    480

atctgggtcc cggacattct catcaatgag ttcgtggatg tggggaagtc tccaaatatc    540

ccgtacgtgt atattcggca tcaaggcgaa gttcagaact acaagcccct tcaggtggtg    600

actgcctgta gcctcgacat ctacaacttc cccttcgatg tccagaactg ctcgctgacc    660

ttcaccagtt ggctgcacac catccaggac atcaacatct ctttgtggcg cttgccagaa    720

aaggtgaaat ccgacaggag tgtcttcatg aaccagggag agtgggagtt gctgggggtg    780

ctgccctact ttcgggagtt cagcatggaa agcagtaact actatgcaga aatgaagttc    840

tatgtggtca tccgccggcg gcccctcttc tatgtggtca gcctgctact gcccagcatc    900

ttcctcatgg tcatggacat cgtgggcttc tacctgcccc ccaacagtgg cgagagggtc    960

tctttcaaga ttacactcct cctgggctac tcggtcttcc tgatcatcgt ttctgacacg   1020

ctgccggcca ctgccatcgg cactcctctc attggtaagg cccctcctgg cagcagagct   1080

cagtctggtg agaaacccgc cccctcccac ctcctgcatg tgtctcttgc ctctgccctg   1140

ggctgcacag gtgtctactt tgtggtgtgc atggctctgc tggtgataag tttggccgag   1200

accatcttca ttgtgcggct ggtgcacaag caagacctgc agcagcccgt gcctgcttgg   1260

ctgcgtcacc tggttctgga gagaatcgcc tggctacttt gcctgaggga gcagtcaact   1320

tcccagaggc ccccagccac ctcccaagcc accaagactg atgactgctc agccatggga   1380

aaccactgca gccacatggg aggaccccag gacttcgaga agagcccgag ggacagatgt   1440

agccctcccc caccacctcg ggaggcctcg ctggcggtgt gtgggctgct gcaggagctg   1500

tcctccatcc ggcaattcct ggaaaagcgg gatgagatcc gagaggtggc ccgagactgg   1560

ctgcgcgtgg gctccgtgct ggacaagctg ctattccaca tttacctgct agcggtgctg   1620

gcctacagca tcaccctggt tatgctctgg tccatctggc agtacgcttg agtgggtaca   1680

gcccagtgga ggagggggta cagtcctggt taggtgggga cagaggattt ctgcttaggc   1740

ccctcaggac ccagggaatg ccagggacat tttcaagaca cagacaaagt cccgtgccct   1800

gtttccaatg ccaattcatc tcagcaatca caagccaagg tctgaaccct tccaccaaaa   1860

actgggtgtt caaggccctt acacccttgt cccaccccca gcagctcacc atggctttaa   1920

aacatgctct cttagatcag gagaaactcg ggcactccct aagtccactc tagttgtgga   1980

cttttcccca ttgaccctca cctgaataag ggactttgga attctgcttc tctttcacaa   2040

ctttgctttt aggttgaagg caaaaccaac tctctactac acaggcctga taactctgta   2100

cgaggcttct ctaaccccta gtgtcttttt tttcttcacc tcacttgtgg cagcttccct   2160

gaacactcat cccccatcag atgatgggag tgggaagaat aaaatgcagt gaaaccctaa   2220

aaaaaaaaaa aaaaaaaaaa aaa                                           2243


<210>  2897
<211>  510
<212>  PRT
<213>  Homosapiens

<400>  2897

Met Leu Leu Trp Val Gln Gln Ala Leu Leu Ala Leu Leu Leu Pro Thr 
1               5                   10                  15      


Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser Arg Asn Thr Thr Arg Pro 
            20                  25                  30          


Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu Thr Asn Tyr Arg Lys Gly 
        35                  40                  45              


Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr Thr Val Ser Ile Asp 
    50                  55                  60                  


Val Ile Val Tyr Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val Leu 
65                  70                  75                  80  


Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp Thr Asp Glu Phe Leu Gln 
                85                  90                  95      


Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr Lys Leu Ser Ile Pro Thr 
            100                 105                 110         


Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn Glu Phe Val Asp Val 
        115                 120                 125             


Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr Ile Arg His Gln Gly Glu 
    130                 135                 140                 


Val Gln Asn Tyr Lys Pro Leu Gln Val Val Thr Ala Cys Ser Leu Asp 
145                 150                 155                 160 


Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Thr 
                165                 170                 175     


Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile Ser Leu Trp Arg Leu 
            180                 185                 190         


Pro Glu Lys Val Lys Ser Asp Arg Ser Val Phe Met Asn Gln Gly Glu 
        195                 200                 205             


Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe Arg Glu Phe Ser Met Glu 
    210                 215                 220                 


Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe Tyr Val Val Ile Arg Arg 
225                 230                 235                 240 


Arg Pro Leu Phe Tyr Val Val Ser Leu Leu Leu Pro Ser Ile Phe Leu 
                245                 250                 255     


Met Val Met Asp Ile Val Gly Phe Tyr Leu Pro Pro Asn Ser Gly Glu 
            260                 265                 270         


Arg Val Ser Phe Lys Ile Thr Leu Leu Leu Gly Tyr Ser Val Phe Leu 
        275                 280                 285             


Ile Ile Val Ser Asp Thr Leu Pro Ala Thr Ala Ile Gly Thr Pro Leu 
    290                 295                 300                 


Ile Gly Lys Ala Pro Pro Gly Ser Arg Ala Gln Ser Gly Glu Lys Pro 
305                 310                 315                 320 


Ala Pro Ser His Leu Leu His Val Ser Leu Ala Ser Ala Leu Gly Cys 
                325                 330                 335     


Thr Gly Val Tyr Phe Val Val Cys Met Ala Leu Leu Val Ile Ser Leu 
            340                 345                 350         


Ala Glu Thr Ile Phe Ile Val Arg Leu Val His Lys Gln Asp Leu Gln 
        355                 360                 365             


Gln Pro Val Pro Ala Trp Leu Arg His Leu Val Leu Glu Arg Ile Ala 
    370                 375                 380                 


Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr Ser Gln Arg Pro Pro Ala 
385                 390                 395                 400 


Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys Ser Ala Met Gly Asn His 
                405                 410                 415     


Cys Ser His Met Gly Gly Pro Gln Asp Phe Glu Lys Ser Pro Arg Asp 
            420                 425                 430         


Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu Ala Ser Leu Ala Val Cys 
        435                 440                 445             


Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg Gln Phe Leu Glu Lys Arg 
    450                 455                 460                 


Asp Glu Ile Arg Glu Val Ala Arg Asp Trp Leu Arg Val Gly Ser Val 
465                 470                 475                 480 


Leu Asp Lys Leu Leu Phe His Ile Tyr Leu Leu Ala Val Leu Ala Tyr 
                485                 490                 495     


Ser Ile Thr Leu Val Met Leu Trp Ser Ile Trp Gln Tyr Ala 
            500                 505                 510 


<210>  2898
<211>  2645
<212>  DNA
<213>  Homosapiens

<400>  2898
aggcaaccat gtggttccag ctgaattttt tttttccctc tctctttctt cactcctttt     60

tctttccaaa cagggaaaag tgttccacga agcggtagcg cctttccgcc tcgcgttttc    120

ctccctgacc ctggtcccgg ctcccgtccg ggcgccagct ggtggggcga gcgccgggag    180

cccatctgcc cccaggggca cggggcgcgg ggccggctcc cgcccggcac atggctgcag    240

ccacctcgcg cgcaccccga ggcgccgcgc ccagctcgcc cgaggtccgt cggaggcgcc    300

cggccgcccc ggagccaagc agcagctgag cggggaagcg cccgcgtccg gggatcggga    360

tgtccctcct ccttctcctc ttgctagttt cctactatgt tggaaccttg gggactcaca    420

ctgagatcaa gagagtggca gaggaaaagg tcactttgcc ctgccaccat caactggggc    480

ttccagaaaa agacactctg gatattgaat ggctgctcac cgataatgaa gggaaccaaa    540

aagtggtgat cacttactcc agtcgtcatg tctacaataa cttgactgag gaacagaagg    600

gccgagtggc ctttgcttcc aatttcctgg caggagatgc ctccttgcag attgaacctc    660

tgaagcccag tgatgagggc cggtacacct gtaaggttaa gaattcaggg cgctacgtgt    720

ggagccatgt catcttaaaa gtcttagtga gaccatccaa gcccaagtgt gagttggaag    780

gagagctgac agaaggaagt gacctgactt tgcagtgtga gtcatcctct ggcacagagc    840

ccattgtgta ttactggcag cgaatccgag agaaagaggg agaggatgaa cgtctgcctc    900

ccaaatctag gattgactac aaccaccctg gacgagttct gctgcagaat cttaccatgt    960

cctactctgg actgtaccag tgcacagcag gcaacgaagc tgggaaggaa agctgtgtgg   1020

tgcgagtaac tgtacagtat gtacaaagca tcggcatggt tgcaggagca gtgacaggca   1080

tagtggctgg agccctgctg attttcctct tggtgtggct gctaatccga aggaaagaca   1140

aagaaagata tgaggaagaa gagagaccta atgaaattcg agaagatgct gaagctccaa   1200

aagcccgtct tgtgaaaccc agctcctctt cctcaggctc tcggagctca cgctctggtt   1260

cttcctccac tcgctccaca gcaaatagtg cctcacgcag ccagcggaca ctgtcaactg   1320

acgcagcacc ccagccaggg ctggccaccc aggcatacag cctagtgggg ccagaggtga   1380

gaggttctga accaaagaaa gtccaccatg ctaatctgac caaagcagaa accacaccca   1440

gcatgatccc cagccagagc agagccttcc aaacggtctg aattacaatg gacttgactc   1500

ccacgctttc ctaggagtca gggtctttgg actcttctcg tcattggagc tcaagtcacc   1560

agccacacaa ccagatgaga ggtcatctaa gtagcagtga gcattgcacg gaacagattc   1620

agatgagcat tttccttata caataccaaa caagcaaaag gatgtaagct gattcatctg   1680

taaaaaggca tcttattgtg cctttagacc agagtaaggg aaagcaggag tccaaatcta   1740

tttgttgacc aggacctgtg gtgagaaggt tggggaaagg tgaggtgaat atacctaaaa   1800

cttttaatgt gggatatttt gtatcagtgc tttgattcac aattttcaag aggaaatggg   1860

atgctgtttg taaattttct atgcatttct gcaaacttat tggattatta gttattcaga   1920

cagtcaagca gaacccacag ccttattaca cctgtctaca ccatgtactg agctaaccac   1980

ttctaagaaa ctccaaaaaa ggaaacatgt gtcttctatt ctgacttaac ttcatttgtc   2040

ataaggtttg gatattaatt tcaaggggag ttgaaatagt gggagatgga gaagagtgaa   2100

tgagtttctc ccactctata ctaatctcac tatttgtatt gagcccaaaa taactatgaa   2160

aggagacaaa aatttgtgac aaaggattgt gaagagcttt ccatcttcat gatgttatga   2220

ggattgttga caaacattag aaatatataa tggagcaatt gtggatttcc cctcaaatca   2280

gatgcctcta aggactttcc tgctagatat ttctggaagg agaaaataca acatgtcatt   2340

tatcaacgtc cttagaaaga attcttctag agaaaaaggg atctaggaat gctgaaagat   2400

tacccaacat accattatag tctcttcttt ctgagaaaat gtgaaaccag aattgcaaga   2460

ctgggtggac tagaaaggga gattagatca gttttctctt aatatgtcaa ggaaggtagc   2520

cgggcatggt gccaggcacc tgtaggaaaa tccagcaggt ggaggttgca gtgagccaag   2580

attatgccat tgcactccag cctgggtgac aaagcaagac tccatctcaa aaaaaaaaaa   2640

aaaaa                                                               2645


<210>  2899
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  2899

Met Ser Leu Leu Leu Leu Leu Leu Leu Val Ser Tyr Tyr Val Gly Thr 
1               5                   10                  15      


Leu Gly Thr His Thr Glu Ile Lys Arg Val Ala Glu Glu Lys Val Thr 
            20                  25                  30          


Leu Pro Cys His His Gln Leu Gly Leu Pro Glu Lys Asp Thr Leu Asp 
        35                  40                  45              


Ile Glu Trp Leu Leu Thr Asp Asn Glu Gly Asn Gln Lys Val Val Ile 
    50                  55                  60                  


Thr Tyr Ser Ser Arg His Val Tyr Asn Asn Leu Thr Glu Glu Gln Lys 
65                  70                  75                  80  


Gly Arg Val Ala Phe Ala Ser Asn Phe Leu Ala Gly Asp Ala Ser Leu 
                85                  90                  95      


Gln Ile Glu Pro Leu Lys Pro Ser Asp Glu Gly Arg Tyr Thr Cys Lys 
            100                 105                 110         


Val Lys Asn Ser Gly Arg Tyr Val Trp Ser His Val Ile Leu Lys Val 
        115                 120                 125             


Leu Val Arg Pro Ser Lys Pro Lys Cys Glu Leu Glu Gly Glu Leu Thr 
    130                 135                 140                 


Glu Gly Ser Asp Leu Thr Leu Gln Cys Glu Ser Ser Ser Gly Thr Glu 
145                 150                 155                 160 


Pro Ile Val Tyr Tyr Trp Gln Arg Ile Arg Glu Lys Glu Gly Glu Asp 
                165                 170                 175     


Glu Arg Leu Pro Pro Lys Ser Arg Ile Asp Tyr Asn His Pro Gly Arg 
            180                 185                 190         


Val Leu Leu Gln Asn Leu Thr Met Ser Tyr Ser Gly Leu Tyr Gln Cys 
        195                 200                 205             


Thr Ala Gly Asn Glu Ala Gly Lys Glu Ser Cys Val Val Arg Val Thr 
    210                 215                 220                 


Val Gln Tyr Val Gln Ser Ile Gly Met Val Ala Gly Ala Val Thr Gly 
225                 230                 235                 240 


Ile Val Ala Gly Ala Leu Leu Ile Phe Leu Leu Val Trp Leu Leu Ile 
                245                 250                 255     


Arg Arg Lys Asp Lys Glu Arg Tyr Glu Glu Glu Glu Arg Pro Asn Glu 
            260                 265                 270         


Ile Arg Glu Asp Ala Glu Ala Pro Lys Ala Arg Leu Val Lys Pro Ser 
        275                 280                 285             


Ser Ser Ser Ser Gly Ser Arg Ser Ser Arg Ser Gly Ser Ser Ser Thr 
    290                 295                 300                 


Arg Ser Thr Ala Asn Ser Ala Ser Arg Ser Gln Arg Thr Leu Ser Thr 
305                 310                 315                 320 


Asp Ala Ala Pro Gln Pro Gly Leu Ala Thr Gln Ala Tyr Ser Leu Val 
                325                 330                 335     


Gly Pro Glu Val Arg Gly Ser Glu Pro Lys Lys Val His His Ala Asn 
            340                 345                 350         


Leu Thr Lys Ala Glu Thr Thr Pro Ser Met Ile Pro Ser Gln Ser Arg 
        355                 360                 365             


Ala Phe Gln Thr Val 
    370             


<210>  2900
<211>  5228
<212>  DNA
<213>  Homosapiens

<400>  2900
cgggcgaggg ccgggcagga ggagcgggcg cggcgcgggc gaggctggga cccgagcgcg     60

ctcacttcgc cgcaaagtgc caacttcccc tggagtgccg ggcgcgcacc gtccgggcgc    120

gggggaaaga aaggcagcgg gaatttgaga tttttgggaa gaaagtcgga tttcccccgt    180

ccccttcccc ctgttactaa tcctcattaa aaagaaaaac aacagtaact gcaaacttgc    240

taccatcccg tacgtccccc actcctggca ccatgaaggc ggccgtcgat ctcaagccga    300

ctctcaccat catcaagacg gaaaaagtcg atctggagct tttcccctcc ccggatatgg    360

aatgtgcaga tgtcccacta ttaactccaa gcagcaaaga aatgatgtct caagcattaa    420

aagctacttt cagtggtttc actaaagaac agcaacgact ggggatccca aaagaccccc    480

ggcagtggac agaaacccat gttcgggact gggtgatgtg ggctgtgaat gaattcagcc    540

tgaaaggtgt agacttccag aagttctgta tgaatggagc agccctctgc gccctgggta    600

aagactgctt tctcgagctg gccccagact ttgttgggga catcttatgg gaacatctag    660

agatcctgca gaaagaggat gtgaaaccat atcaagttaa tggagtcaac ccagcctatc    720

cagaatcccg ctatacctcg gattacttca ttagctatgg tattgagcat gcccagtgtg    780

ttccaccatc ggagttctca gagcccagct tcatcacaga gtcctatcag acgctccatc    840

ccatcagctc ggaagagctc ctctccctca agtatgagaa tgactacccc tcggtcattc    900

tccgagaccc tctccagaca gacaccttgc agaatgacta ctttgctatc aaacaagaag    960

tcgtcacccc agacaacatg tgcatgggga ggaccagtcg tggtaaactc gggggccagg   1020

actcttttga aagcatagag agctacgata gttgtgatcg cctcacccag tcctggagca   1080

gccagtcatc tttcaacagc ctgcagcgtg ttccctccta tgacagcttc gactcagagg   1140

actatccggc tgccctgccc aaccacaagc ccaagggcac cttcaaggac tatgtgcggg   1200

accgtgctga cctcaataag gacaagcctg tcattcctgc tgctgcccta gctggctaca   1260

caggcagtgg accaatccag ctatggcagt ttcttctgga attactcact gataaatcct   1320

gtcagtcttt tatcagctgg acaggagatg gctgggaatt caaactttct gacccagatg   1380

aggtggccag gagatgggga aagaggaaaa acaaacctaa gatgaattat gagaaactga   1440

gccgtggcct acgctactat tacgacaaaa acatcatcca caagacagcg gggaaacgct   1500

acgtgtaccg ctttgtgtgt gacctgcaga gcctgctggg gtacacccct gaggagctgc   1560

acgccatgct ggacgtcaag ccagatgccg acgagtgatg gcactgaagg ggctggggaa   1620

accctgctga gaccttccaa ggacagccgt gttggttgga ctctgaattt tgaattgtta   1680

ttctattttt tattttccag aactcatttt ttaccttcag gggtgggagc taagtcagtt   1740

gcagctgtaa tcaattgtgc gcagttggga aaggaaagcc aggacttgtg gggtgggtgg   1800

gaccagaaat tcttgagcaa attttcagga gagggagaag ggccttctca gaagcttgaa   1860

ggctctggct taacagagaa agagactaat gtgtccaatc atttttaaaa atcatccatg   1920

aaaaagtgtc ttgagttgtg gacccattag caagtgacat tgtcacatca gaactcatga   1980

aactgatgta aggcaattaa tttgcttctg tttttaggtc tgggagggca aaaaagaggt   2040

gggtgggatg aaacatgttt tgggggggga tgcactgaaa atctgagaac tatttaccta   2100

tcactctagt tttgaagcaa agatggactt cagtggggag gggccaaaac cgttgttgtg   2160

ttaaaattta ttttattaaa ttttgtgcca gtattttttt tcttaaaaat cgtcttaagc   2220

tctaaggtgg tctcagtatt gcaatatcat gtaagtttgt ttttatttgc cggctgagga   2280

ttctgtcaca atgaaagaaa actgtttata tagaccccat tggaaaagca aaacgctctc   2340

actgagatca gggatcccaa attcatggga cttatataag aaggacaatt aatgctgatt   2400

tgggtacagg ggaattatgt gtgtgaatgt catctacaat taaaaaaaat tagcacatcc   2460

ctttacttac ttgttatcag tggattctcg gggtttggac ttaatgttga gctaagaagc   2520

attaagtctt tgaactgaat gtattttgca tccctggttt tggacgacag taaacgtagg   2580

agcactgttg aagtcctgga agggagatcg aaggaggaag attgacttgg ttctttctta   2640

gtcctatatc tgtagcatag atgacttgga ataaaagctg tatgcatggg cattacccct   2700

caggtcctaa gaaataagtc ctgaatgcat gtcgttccaa actaacactc tgtaattttt   2760

cttttatgtc ttattttcca agagtcctcc attttttgca ccccctcacc gccaactctg   2820

ttattcagta gagagaagtg tacggctttc tgattggtga gtgaaaaagt aacttgagac   2880

acgacctaag ttgaagagtt tagacttgct gagttttaga agtgatggaa attaagagag   2940

catttcaata aaatgtgact tggctgtctt tggaagagaa gtgcaaggct ttcctttgaa   3000

gaatttaaat tagtccggta ggatgtcagg tgagactgtg tatgcaaaat gaatggcaca   3060

ggtgatgcca gggcctcttg cttgggtctg atgtcttggc acagggtaag tgaaggttaa   3120

ttccagaaga gaggaatgac ttgaaggcaa aggaaactaa ggaaggaggt tcagtgagga   3180

aaataaggtt gtccatgaga tttgaataga tttttagttc ccccaaggtt taaatacaaa   3240

catagtcaag caaggtagtc atctttctgc tggttgtgag ggggaatctg aaaatggagt   3300

tttagaggaa aagtcaacat ctaactagtg aggaaaagtg cctaatacaa ttagaatctc   3360

cctcactcta tagttgccca gttgaaagga taaggaggag gggtggcttt tatggacttc   3420

catgagagaa ggaaagaaat atttcaggta agcttctcag ggctggccct ttttgggatt   3480

tggatgagaa attggaagta ctaactactt tctagcatat ctttaagaaa attgattgtt   3540

atttactccc agatcctctt gcagacccag aattatcagg aacatagctc tgtgattcat   3600

gagtgtcccc atactgatga attggagcat ccatatggaa agcaaaggca gaattatccc   3660

agctgtatta ttttgatctt ttggatgcag gtgccttaat gaagctctca aaatatttta   3720

ggagctgctc agggagtgtt gggtggaact gtttggacta cattgttttc tcttagatta   3780

tgtgattttt gttgggcact ggcaaaaggt gtgtgtgtga atgtgtgcat gtgtgtgaat   3840

gttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tttgcagaca tgcaaaactg   3900

cagctgaaat aataccttag atttctaggt aagtctttcc acatttcaat aatgggtaag   3960

agtagaacca gggccgggta tcaattattg cttgctgttt gcaaccaggc ataaaatcac   4020

tttctcaaat catccaccgt tcctattaaa tttatgccgg aaactctcct tctgtgagta   4080

taactcctgc agttcctata gcagataaga tataagaaag tgcctcctag tgctcctccg   4140

cccgcttgtt tgctaaaatt ccctttctct ctaagtccac cattttcaag atttgtagat   4200

agtgtattag ttaagacagc tttgtcgatc tggccagatg ttttttctcc tttgtccaaa   4260

ggccagagac catcccagga agagtggtgg gtggtttata cactggaaat gttgcgttta   4320

tgctttttaa aaacacacgt taacttcaga ggaaggatgg gcaaatctgg tctagctggg   4380

tgaaaccctt attttcccag agatgcctta acctttgttg gttttggctt tagggttcag   4440

agtcactttt gttcccttct ccattctgga gagggacttc ccctacatag agccctgatt   4500

tttgtggctg tggggattgg aggtagcatt caaagatcag atgtgctttt cctcactttg   4560

gagatgaaca ctctgggttt tacagcatta acctgcctaa ccttcatggt gagaaataca   4620

ccatctctct tctagtcatg ctgtgcatgc cgcttactct gttggggtct atataaattt   4680

gttgaactct tacctacatt ccaaagaagt ttcaaggaac cataaatata tgtatacata   4740

tacatatata aaatatatat attaaaataa aattatcagg aatactgcct cagttattga   4800

actttttttt ttaagaatac ttttttttta agctgagaag tatagggatg aaaaagatgt   4860

tatattgtgt ttgactattt tccaacttgt attttcatat aatttatatt ttttaaaagc   4920

tgaaaattta gaagcaagat gaaaaaaagg aaaagcaggt gctttttaaa aatcagaact   4980

gaggtagctt agagatgtag cgatgtaagt gtcgatgttt ttttaaaaaa aaatgcaaaa   5040

aaattcttat ggcggagttt tttgtttgtt tattttagta gctgatgctg gcacatcatt   5100

ttgctggaga gttttttata tactgtagcc tgatttcata ttgtatttta aactgtgtga   5160

aattaaaaac aaagaatttc attcataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   5220

aaaaaaaa                                                            5228


<210>  2901
<211>  441
<212>  PRT
<213>  Homosapiens

<400>  2901

Met Lys Ala Ala Val Asp Leu Lys Pro Thr Leu Thr Ile Ile Lys Thr 
1               5                   10                  15      


Glu Lys Val Asp Leu Glu Leu Phe Pro Ser Pro Asp Met Glu Cys Ala 
            20                  25                  30          


Asp Val Pro Leu Leu Thr Pro Ser Ser Lys Glu Met Met Ser Gln Ala 
        35                  40                  45              


Leu Lys Ala Thr Phe Ser Gly Phe Thr Lys Glu Gln Gln Arg Leu Gly 
    50                  55                  60                  


Ile Pro Lys Asp Pro Arg Gln Trp Thr Glu Thr His Val Arg Asp Trp 
65                  70                  75                  80  


Val Met Trp Ala Val Asn Glu Phe Ser Leu Lys Gly Val Asp Phe Gln 
                85                  90                  95      


Lys Phe Cys Met Asn Gly Ala Ala Leu Cys Ala Leu Gly Lys Asp Cys 
            100                 105                 110         


Phe Leu Glu Leu Ala Pro Asp Phe Val Gly Asp Ile Leu Trp Glu His 
        115                 120                 125             


Leu Glu Ile Leu Gln Lys Glu Asp Val Lys Pro Tyr Gln Val Asn Gly 
    130                 135                 140                 


Val Asn Pro Ala Tyr Pro Glu Ser Arg Tyr Thr Ser Asp Tyr Phe Ile 
145                 150                 155                 160 


Ser Tyr Gly Ile Glu His Ala Gln Cys Val Pro Pro Ser Glu Phe Ser 
                165                 170                 175     


Glu Pro Ser Phe Ile Thr Glu Ser Tyr Gln Thr Leu His Pro Ile Ser 
            180                 185                 190         


Ser Glu Glu Leu Leu Ser Leu Lys Tyr Glu Asn Asp Tyr Pro Ser Val 
        195                 200                 205             


Ile Leu Arg Asp Pro Leu Gln Thr Asp Thr Leu Gln Asn Asp Tyr Phe 
    210                 215                 220                 


Ala Ile Lys Gln Glu Val Val Thr Pro Asp Asn Met Cys Met Gly Arg 
225                 230                 235                 240 


Thr Ser Arg Gly Lys Leu Gly Gly Gln Asp Ser Phe Glu Ser Ile Glu 
                245                 250                 255     


Ser Tyr Asp Ser Cys Asp Arg Leu Thr Gln Ser Trp Ser Ser Gln Ser 
            260                 265                 270         


Ser Phe Asn Ser Leu Gln Arg Val Pro Ser Tyr Asp Ser Phe Asp Ser 
        275                 280                 285             


Glu Asp Tyr Pro Ala Ala Leu Pro Asn His Lys Pro Lys Gly Thr Phe 
    290                 295                 300                 


Lys Asp Tyr Val Arg Asp Arg Ala Asp Leu Asn Lys Asp Lys Pro Val 
305                 310                 315                 320 


Ile Pro Ala Ala Ala Leu Ala Gly Tyr Thr Gly Ser Gly Pro Ile Gln 
                325                 330                 335     


Leu Trp Gln Phe Leu Leu Glu Leu Leu Thr Asp Lys Ser Cys Gln Ser 
            340                 345                 350         


Phe Ile Ser Trp Thr Gly Asp Gly Trp Glu Phe Lys Leu Ser Asp Pro 
        355                 360                 365             


Asp Glu Val Ala Arg Arg Trp Gly Lys Arg Lys Asn Lys Pro Lys Met 
    370                 375                 380                 


Asn Tyr Glu Lys Leu Ser Arg Gly Leu Arg Tyr Tyr Tyr Asp Lys Asn 
385                 390                 395                 400 


Ile Ile His Lys Thr Ala Gly Lys Arg Tyr Val Tyr Arg Phe Val Cys 
                405                 410                 415     


Asp Leu Gln Ser Leu Leu Gly Tyr Thr Pro Glu Glu Leu His Ala Met 
            420                 425                 430         


Leu Asp Val Lys Pro Asp Ala Asp Glu 
        435                 440     


<210>  2902
<211>  3748
<212>  DNA
<213>  Homosapiens

<400>  2902
cgtctgtaaa cacccagaga ctgtcatgga gggggaggag gaggcggcgg cggcgaaggg     60

aggcgtttgg ggccgcctcc agggtccgct ctgccattcc tgaactggtc cctcgtcccc    120

gtgactctgg catcagggaa gcgaactgtt aggcgagagg aggaggcagc cagaaccata    180

tccccttctt cctcggggcg ggggccgggc caggccggct gagccggggg agggctccgg    240

gagggagtgc ctggccaggc cggcctgtct gccgcgatgg atgacagtaa ggtggttgga    300

ggcaaagtaa agaagcccgg taaacgtggt cggaagccag ccaaaattga cttgaaagca    360

aaacttgaga ggagccggca gagtgcaaga gaatgccgag cccgaaaaaa gctgagatat    420

cagtatttgg aagagttggt atccagtcga gaaagagcta tatgtgccct cagagaggaa    480

ctggaaatgt acaagcagtg gtgcatggca atggaccaag gaaaaatccc ttctgaaata    540

aaggccctac tcactggaga agagcagaac aaatctcagc agaactcaag caggcatacc    600

aaggctggga agacagatgc taatagcaat tcctggtgaa gattatataa agatgagtca    660

gtgattgaag ccaatattct gattcccatg gaagatggat gggcaagagt gtacttcttg    720

gctccattta ctacctactg ctcagtagtc atctctgtaa atctgcaatt tctaccaaaa    780

tgtgtgatcg tagatctcaa aggatcttgc tttaactttc aacacttaga aaatctacaa    840

acattcagac ctgtctgggt tggtattgcc acccatgaca tttaacatgt tgtgatgctt    900

gaaaacacag gagtagagaa aatcgatgaa gattgtattt ttgcacctta actccacatt    960

gctttattgg ttaatttata ttctttccat gtaattcatg taattgtatg tctgtgtgtg   1020

ttttatgtgt caccaccttt catgtttttg attgccctac aaagagaaac caaatgagct   1080

gattactgac tataagttct cagcctttat ggacctaatc ttatttttat ttacttgagt   1140

aatgtttatt ctctgcatga accatgattt ctcctgtgag ccattccagc ataagctgtg   1200

aatatgtatt aacaaatata tacatttcta tttttataat ccataaggat atgcctgttt   1260

taaataacat acatattaac aatatctatc aggaaaaccc tcaagacagc ttctagttaa   1320

aacctttgtt gctgtcctct caaactatat ttataaaaat ttgctagggc caaatccata   1380

cttgcagaat aattcatcaa attttatttt taagtgaaaa gtaacctttc aggcatttca   1440

gcagcataca ttgacaatct agggtatata tgtatgtatg tttcttattg tatgtctata   1500

tatgtatgtg gggaggacag gagtgaatgt tcacacactt ttcttgcgta ctcaactaaa   1560

ttggagaatg tttctgaaga aaattggatg aaattagctg ctgagattga gtttctgcct   1620

taaaatctga aacaaaaaaa gggacaaatt gctggtagat ctactgactg tagccatcac   1680

cagaacactt agtttcttcc cagacatgaa tttcctgaca ggctctgagc cagaaacaca   1740

ctgtgggcgt gcatctggtt cagccctgga tatgcctcca ctgtggaggg aagcattgga   1800

actggagttg tgcacagcac cgcagctagt gggcctggct gggggtgcag aagggcaggg   1860

tagttctttc catttcccct tgcagctaca cttactttct ccctgactac caaatggagt   1920

gacggttgaa gaatcaagct cataatatga tacacccaga cagacccaga aatcttttga   1980

tttccccagc gagatactta ccactctctc ttctctttcc catggttaaa acaggagttg   2040

tgttctctgt cgctgctaaa ttattcttca cttgagtgaa gcaaatattt agcttccaaa   2100

taaagtatat tttgttctga actggcagtt taagaggaga taccgtagtc tagattgtct   2160

ttgaggtaga atatatgatg gaccacatag tttaagatta caaggtactt tccctcttct   2220

ctcaggccat gcatttgaat aaagtgcctc ccttagcctg agctcctaaa gacctcttgt   2280

acttggttgc aaactcagat ctctagtcta gtctagtcta gtctagtcta gtcatgtgtg   2340

actgtgtact gagataccac tagcccagtt tgctgggtct ctatgttttg gaagttgggg   2400

gtttaataat atttaatgtc tttttaggat cataaacata aataggtttg ttgatattca   2460

ggccttcaga atttaagggt tttaaatata gcattcagat tgtaattggt atgtttttgc   2520

catctggtcc actcaattgt atatttttat tttgcaaaac aacccaaaac ttactttatg   2580

ttgctttgtt cagtaccttt tgaattcccc cagaagagtt gttttcaaaa caaacattcc   2640

agaatgaatg tcgctcttca atggaacgtc tttattgtgc ttgaagtatt tcttctctgg   2700

ttgtaattct aaattacaga gtcatttgag ctttctcccc tcccgctagt atctttacag   2760

gagcagggaa gagcagtaga ggatgtataa ttttgggcga agttaaatta caatttattt   2820

gaggttattc ctaaacctat ttatttggtg ttttggagga gatcacacac taagagaacg   2880

ttgattgcct cggctattgt gctggctgga cactttggtc acttttgaag catgttaata   2940

aatgtcactg attaaaacag ctggagcatt tccttccctt tccagtgaag gagcagcata   3000

gtgaaatcct ggcacccctc acctttttgt gatgacaaga tggctgacag tcacggagtc   3060

caggagaagg tgctgctctc cttgctttct gagtaaacag agtaatgttt tttttcttat   3120

tttcccaaag aaagaaaagg gggaaaatat atttgtatgt ttagaccagc caaattctgt   3180

cattatttta gtatcaacct gctgtatatt agagcaactg aatataatat ggaataagtt   3240

tgaccaggtc aagttttagg atatagttga atttctttaa aaagttttct attttatcta   3300

aaatctttct attatatcta aattagaatg atcatcctgc gcaaattcag attactgttt   3360

gctggctaat tgacagtatt tctcagcatc actatgtagc attctgtttt agcatctttg   3420

aattatgatc atttgatttg gctaattaca aaaagtacag gtttaaactg gacttacctt   3480

gagttaaagg caaagaaaat ctaaaaacat aaatgttata tttcacaaga aatcagttgc   3540

atattatcca ttacatattt agttttaaaa ggaggagtca ccttgaatta ttttctgagt   3600

caccttgagt tatttgatct ctcagcctgc tttctcatct gtaaaaaagg ggggaggata   3660

actttcacag ggtaattggt aggctaaata ggagttacag aaaactgtta aatagggaag   3720

aactacatta aatttaaata ttcacatt                                      3748


<210>  2903
<211>  120
<212>  PRT
<213>  Homosapiens

<400>  2903

Met Asp Asp Ser Lys Val Val Gly Gly Lys Val Lys Lys Pro Gly Lys 
1               5                   10                  15      


Arg Gly Arg Lys Pro Ala Lys Ile Asp Leu Lys Ala Lys Leu Glu Arg 
            20                  25                  30          


Ser Arg Gln Ser Ala Arg Glu Cys Arg Ala Arg Lys Lys Leu Arg Tyr 
        35                  40                  45              


Gln Tyr Leu Glu Glu Leu Val Ser Ser Arg Glu Arg Ala Ile Cys Ala 
    50                  55                  60                  


Leu Arg Glu Glu Leu Glu Met Tyr Lys Gln Trp Cys Met Ala Met Asp 
65                  70                  75                  80  


Gln Gly Lys Ile Pro Ser Glu Ile Lys Ala Leu Leu Thr Gly Glu Glu 
                85                  90                  95      


Gln Asn Lys Ser Gln Gln Asn Ser Ser Arg His Thr Lys Ala Gly Lys 
            100                 105                 110         


Thr Asp Ala Asn Ser Asn Ser Trp 
        115                 120 


<210>  2904
<211>  1409
<212>  DNA
<213>  Homosapiens

<400>  2904
aattaagaga aaaaaagtga atatggtttt tgctcacaga atggataaca gcaagccaca     60

tttgattatt cctacacttc tggtgcccct ccaaaaccgc agctgcactg aaacagccac    120

acctctgcca agccaatacc tgatggaatt aagtgaggag cacagttgga tgagcaacca    180

aacagacctt cactatgtgc tgaaacccgg ggaagtggcc acagccagca tcttctttgg    240

gattctgtgg ttgttttcta tcttcggcaa ttccctggtt tgtttggtca tccataggag    300

taggaggact cagtctacca ccaactactt tgtggtctcc atggcatgtg ctgaccttct    360

catcagcgtt gccagcacgc ctttcgtcct gctccagttc accactggaa ggtggacgct    420

gggtagtgca acgtgcaagg ttgtgcgata ttttcaatat ctcactccag gtgtccagat    480

ctacgttctc ctctccatct gcatagaccg gttctacacc atcgtctatc ctctgagctt    540

caaggtgtcc agagaaaaag ccaagaaaat gattgcggca tcgtggatct ttgatgcagg    600

ctttgtgacc cctgtgctct ttttctatgg ctccaactgg gacagtcatt gtaactattt    660

cctcccctcc tcttgggaag gcactgccta cactgtcatc cacttcttgg tgggctttgt    720

gattccatct gtcctcataa ttttatttta ccaaaaggtc ataaaatata tttggagaat    780

aggcacagat ggccgaacgg tgaggaggac aatgaacatt gtccctcgga caaaagtgaa    840

aactatcaag atgttcctca ttttaaatct gttgtttttg ctctcctggc tgccttttca    900

tgtagctcag ctatggcacc cccatgaaca agactataag aaaagttccc ttgttttcac    960

agctatcaca tggatatcct ttagttcttc agcctctaaa cctactctgt attcaattta   1020

taatgccaat tttcggagag ggatgaaaga gactttttgc atgtcctcta tgaaatgtta   1080

ccgaagcaat gcctatacta tcacaacaag ttcaaggatg gccaaaaaaa actacgttgg   1140

catttcagaa atcccttcca tggccaaaac tattaccaaa gactcgatct atgactcatt   1200

tgacagagaa gccaaggaaa aaaagcttgc ttggcccatt aactcaaatc caccaaatac   1260

ttttgtctaa gttctcattc tttcaattgt tatgcaccag agattaaaaa gctttaacta   1320

taaaaacaga agctatttac atatttgttt tcactcaact ttccaaggga aatgttttat   1380

tttgtaaaat gcattcattt gtttactgt                                     1409


<210>  2905
<211>  415
<212>  PRT
<213>  Homosapiens

<400>  2905

Met Val Phe Ala His Arg Met Asp Asn Ser Lys Pro His Leu Ile Ile 
1               5                   10                  15      


Pro Thr Leu Leu Val Pro Leu Gln Asn Arg Ser Cys Thr Glu Thr Ala 
            20                  25                  30          


Thr Pro Leu Pro Ser Gln Tyr Leu Met Glu Leu Ser Glu Glu His Ser 
        35                  40                  45              


Trp Met Ser Asn Gln Thr Asp Leu His Tyr Val Leu Lys Pro Gly Glu 
    50                  55                  60                  


Val Ala Thr Ala Ser Ile Phe Phe Gly Ile Leu Trp Leu Phe Ser Ile 
65                  70                  75                  80  


Phe Gly Asn Ser Leu Val Cys Leu Val Ile His Arg Ser Arg Arg Thr 
                85                  90                  95      


Gln Ser Thr Thr Asn Tyr Phe Val Val Ser Met Ala Cys Ala Asp Leu 
            100                 105                 110         


Leu Ile Ser Val Ala Ser Thr Pro Phe Val Leu Leu Gln Phe Thr Thr 
        115                 120                 125             


Gly Arg Trp Thr Leu Gly Ser Ala Thr Cys Lys Val Val Arg Tyr Phe 
    130                 135                 140                 


Gln Tyr Leu Thr Pro Gly Val Gln Ile Tyr Val Leu Leu Ser Ile Cys 
145                 150                 155                 160 


Ile Asp Arg Phe Tyr Thr Ile Val Tyr Pro Leu Ser Phe Lys Val Ser 
                165                 170                 175     


Arg Glu Lys Ala Lys Lys Met Ile Ala Ala Ser Trp Ile Phe Asp Ala 
            180                 185                 190         


Gly Phe Val Thr Pro Val Leu Phe Phe Tyr Gly Ser Asn Trp Asp Ser 
        195                 200                 205             


His Cys Asn Tyr Phe Leu Pro Ser Ser Trp Glu Gly Thr Ala Tyr Thr 
    210                 215                 220                 


Val Ile His Phe Leu Val Gly Phe Val Ile Pro Ser Val Leu Ile Ile 
225                 230                 235                 240 


Leu Phe Tyr Gln Lys Val Ile Lys Tyr Ile Trp Arg Ile Gly Thr Asp 
                245                 250                 255     


Gly Arg Thr Val Arg Arg Thr Met Asn Ile Val Pro Arg Thr Lys Val 
            260                 265                 270         


Lys Thr Ile Lys Met Phe Leu Ile Leu Asn Leu Leu Phe Leu Leu Ser 
        275                 280                 285             


Trp Leu Pro Phe His Val Ala Gln Leu Trp His Pro His Glu Gln Asp 
    290                 295                 300                 


Tyr Lys Lys Ser Ser Leu Val Phe Thr Ala Ile Thr Trp Ile Ser Phe 
305                 310                 315                 320 


Ser Ser Ser Ala Ser Lys Pro Thr Leu Tyr Ser Ile Tyr Asn Ala Asn 
                325                 330                 335     


Phe Arg Arg Gly Met Lys Glu Thr Phe Cys Met Ser Ser Met Lys Cys 
            340                 345                 350         


Tyr Arg Ser Asn Ala Tyr Thr Ile Thr Thr Ser Ser Arg Met Ala Lys 
        355                 360                 365             


Lys Asn Tyr Val Gly Ile Ser Glu Ile Pro Ser Met Ala Lys Thr Ile 
    370                 375                 380                 


Thr Lys Asp Ser Ile Tyr Asp Ser Phe Asp Arg Glu Ala Lys Glu Lys 
385                 390                 395                 400 


Lys Leu Ala Trp Pro Ile Asn Ser Asn Pro Pro Asn Thr Phe Val 
                405                 410                 415 


<210>  2906
<211>  2422
<212>  DNA
<213>  Homosapiens

<400>  2906
gtcagcctcc cttccaccgc catattgggc cactaaaaaa agggggctcg tcttttcggg     60

gtgtttttct ccccctcccc tgtccccgct tgctcacggc tctgcgactc cgacgccggc    120

aaggtttgga gagcggctgg gttcgcggga cccgcgggct tgcacccgcc cagactcgga    180

cgggctttgc caccctctcc gcttgcctgg tcccctctcc tctccgccct cccgctcgcc    240

agtccatttg atcagcggag actcggcggc cgggccgggg cttccccgca gcccctgcgc    300

gctcctagag ctcgggccgt ggctcgtcgg ggtctgtgtc ttttggctcc gagggcagtc    360

gctgggcttc cgagaggggt tcgggccgcg taggggcgct ttgttttgtt cggttttgtt    420

tttttgagag tgcgagagag gcggtcgtgc agacccggga gaaagatgtc aaacgtgcga    480

gtgtctaacg ggagccctag cctggagcgg atggacgcca ggcaggcgga gcaccccaag    540

ccctcggcct gcaggaacct cttcggcccg gtggaccacg aagagttaac ccgggacttg    600

gagaagcact gcagagacat ggaagaggcg agccagcgca agtggaattt cgattttcag    660

aatcacaaac ccctagaggg caagtacgag tggcaagagg tggagaaggg cagcttgccc    720

gagttctact acagaccccc gcggcccccc aaaggtgcct gcaaggtgcc ggcgcaggag    780

agccaggatg tcagcgggag ccgcccggcg gcgcctttaa ttggggctcc ggctaactct    840

gaggacacgc atttggtgga cccaaagact gatccgtcgg acagccagac ggggttagcg    900

gagcaatgcg caggaataag gaagcgacct gcaaccgacg attcttctac tcaaaacaaa    960

agagccaaca gaacagaaga aaatgtttca gacggttccc caaatgccgg ttctgtggag   1020

cagacgccca agaagcctgg cctcagaaga cgtcaaacgt aaacagctcg aattaagaat   1080

atgtttcctt gtttatcaga tacatcactg cttgatgaag caaggaagat atacatgaaa   1140

attttaaaaa tacatatcgc tgacttcatg gaatggacat cctgtataag cactgaaaaa   1200

caacaacaca ataacactaa aattttaggc actcttaaat gatctgcctc taaaagcgtt   1260

ggatgtagca ttatgcaatt aggtttttcc ttatttgctt cattgtacta cctgtgtata   1320

tagtttttac cttttatgta gcacataaac tttggggaag ggagggcagg gtggggctga   1380

ggaactgacg tggagcgggg tatgaagagc ttgctttgat ttacagcaag tagataaata   1440

tttgacttgc atgaagagaa gcaattttgg ggaagggttt gaattgtttt ctttaaagat   1500

gtaatgtccc tttcagagac agctgatact tcatttaaaa aaatcacaaa aatttgaaca   1560

ctggctaaag ataattgcta tttattttta caagaagttt attctcattt gggagatctg   1620

gtgatctccc aagctatcta aagtttgtta gatagctgca tgtggctttt ttaaaaaagc   1680

aacagaaacc tatcctcact gccctcccca gtctctctta aagttggaat ttaccagtta   1740

attactcagc agaatggtga tcactccagg tagtttgggg caaaaatccg aggtgcttgg   1800

gagttttgaa tgttaagaat tgaccatctg cttttattaa atttgttgac aaaattttct   1860

cattttcttt tcacttcggg ctgtgtaaac acagtcaaaa taattctaaa tccctcgata   1920

tttttaaaga tctgtaagta acttcacatt aaaaaatgaa atatttttta atttaaagct   1980

tactctgtcc atttatccac aggaaagtgt tatttttaaa ggaaggttca tgtagagaaa   2040

agcacacttg taggataagt gaaatggata ctacatcttt aaacagtatt tcattgcctg   2100

tgtatggaaa aaccatttga agtgtacctg tgtacataac tctgtaaaaa cactgaaaaa   2160

ttatactaac ttatttatgt taaaagattt tttttaatct agacaatata caagccaaag   2220

tggcatgttt tgtgcatttg taaatgctgt gttgggtaga ataggttttc ccctcttttg   2280

ttaaataata tggctatgct taaaaggttg catactgagc caagtataat tttttgtaat   2340

gtgtgaaaaa gatgccaatt attgttacac attaagtaat caataaagaa aacttccata   2400

gctaaaaaaa aaaaaaaaaa aa                                            2422


<210>  2907
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  2907

Met Ser Asn Val Arg Val Ser Asn Gly Ser Pro Ser Leu Glu Arg Met 
1               5                   10                  15      


Asp Ala Arg Gln Ala Glu His Pro Lys Pro Ser Ala Cys Arg Asn Leu 
            20                  25                  30          


Phe Gly Pro Val Asp His Glu Glu Leu Thr Arg Asp Leu Glu Lys His 
        35                  40                  45              


Cys Arg Asp Met Glu Glu Ala Ser Gln Arg Lys Trp Asn Phe Asp Phe 
    50                  55                  60                  


Gln Asn His Lys Pro Leu Glu Gly Lys Tyr Glu Trp Gln Glu Val Glu 
65                  70                  75                  80  


Lys Gly Ser Leu Pro Glu Phe Tyr Tyr Arg Pro Pro Arg Pro Pro Lys 
                85                  90                  95      


Gly Ala Cys Lys Val Pro Ala Gln Glu Ser Gln Asp Val Ser Gly Ser 
            100                 105                 110         


Arg Pro Ala Ala Pro Leu Ile Gly Ala Pro Ala Asn Ser Glu Asp Thr 
        115                 120                 125             


His Leu Val Asp Pro Lys Thr Asp Pro Ser Asp Ser Gln Thr Gly Leu 
    130                 135                 140                 


Ala Glu Gln Cys Ala Gly Ile Arg Lys Arg Pro Ala Thr Asp Asp Ser 
145                 150                 155                 160 


Ser Thr Gln Asn Lys Arg Ala Asn Arg Thr Glu Glu Asn Val Ser Asp 
                165                 170                 175     


Gly Ser Pro Asn Ala Gly Ser Val Glu Gln Thr Pro Lys Lys Pro Gly 
            180                 185                 190         


Leu Arg Arg Arg Gln Thr 
        195             


<210>  2908
<211>  4608
<212>  DNA
<213>  Homosapiens

<400>  2908
gacagaagtg aatgggaatg gagaggccgg cggcccggga gccgcatggg cccgacgcgc     60

tgcggcgctt ccagggactg ctgctggacc gccgaggccg gctgcaccgc caggtgctgc    120

gcctgcgcga ggtggcccgg cgcctggagc gcctgcgcag gcgctccctc gtagccaacg    180

tggccggcag ctcgctgagc gcaacgggcg ccctcgccgc catcgtgggg ctctcgctca    240

gcccggtcac cctggggacc tcgctgctgg tgtcggccgt ggggctgggg gtggccacag    300

ccggaggggc cgtcaccatc acgtccgatc tctcgctgat cttctgcaac tcccgggagc    360

tgcggagggt gcaggagatc gcggccacct gccaggacca gatgcgagag atcctgagct    420

gcctcgagtt tttctgccgc tggcagggct gcggggaccg ccagctgctg cagtgcggga    480

ggaacgcctc catcgccctg tacaattctg tctacttcat cgtcttcttt ggctcacgtg    540

gcttcctcat ccccaggcgg gcggaggggg acaccaaggt tagccaggcc gtgctgaagg    600

ccaagattca gaaactggcc gagagcctgg agtcctgcac cggggctctg gacgaactca    660

gcgagcagct ggagtctcgg gttcagctct gcaccaagtc cagtcgtggc cacgacctca    720

agatctctgc tgaccagcgt gcagggctgt ttttctgaga acatcctttc cccctaatga    780

ccgaggccag caaatcatcc tcatgggatg ctccagaatt tgtagctccc ttaggaaaac    840

accaagctgg gttaggagcc gaaggcaaag gatgagaaaa actgtttttg aagtgggcag    900

gtccccaaag cccttctttt cccatcactg tgacatctgc ctgggcttga gtgctacgga    960

cttttcagtc ttcctagtgg aaaaatgtga cccaaaaact ccttttcctt tatcaaaaac   1020

tttctgtcta aacacagctg ggcaggcact cctgttttaa agttatttcg gggtccctga   1080

ccctgccctg gtggcttggc ctgagactgg agagagtgcc atcctctggg tcctctccaa   1140

gtcctactag tctttgaagt cctcaaaatg tgcgtgagga aggcatttgc ctctattcca   1200

gaatttctga tacaaagaac tccagaatcc agagcaaatc agcccttctc tgaacgttgt   1260

aggatggttc agaacccaga gaggaccctg gtgctgatat ctcctcctct tccctttccc   1320

ctcagcttac ttactcccag atgcggcctg ggtatgaagt aggcctttcc tgagtggctc   1380

ccaatccagt cctccaagta ctcagagggg aagcccgtga agccgtcatc taagtcctgc   1440

tccctcacat gaagctgagg gccagataga tggagcgact gccaacttca tttcccgaca   1500

tcattgtgtt cagaagagag tgatgggttt tgagttagac agtcctgggc ttgagacagg   1560

ctttgtcact actgtgtgag tgtagccacc taatctctct gagactgtgt aaaacaaaga   1620

tgataaaatc tcaccctgtt gtgagatatt aaatgagcca aagtgcctag catgatggtg   1680

ctggctcata tagtgtagtc cctggaatgg caaattaaca tcacccagga acttgttaga   1740

aaggcaaatt cttggacaca accctcctga tttatggaat cagaaactct ggctgtgggg   1800

cccagcaacc tgagtttaaa caatttctct gggtggttct gcggcacact aaggtttgaa   1860

aatcactaca acaaatgcta acttctaatc cccttgatga gctttcacga agtctcacgg   1920

cttctctagg gactccatgg tcttcagagt cgttcacaga tgaccaagga cagactgtgt   1980

cccagaagcc aaaatgagag agagagagag agcacgcgta cgtgcaccct ggggcagtgt   2040

ctcaccgtat gaataaggga tgtaacacta aaagcccatt agggggcagt gtttcccgcc   2100

tgttgtagaa actggtacag aaaggatcct atatgaagtt cctgaaactg acctttgtct   2160

attattacct tctctgaaaa gtgccagtcc atgtattttt tatttatttt aagtttgtaa   2220

tttaattttt aattattgtt tagtgtttgc atttaatttt atttaatcac cacatttaga   2280

aaataataag agcaagtttc taaatgggag actgctgagg ctctttgcaa gagatgagat   2340

taagtttgag tttctaaggc agggcatgag ctggaaatag cattgctttc cttgattgtc   2400

tctctccttc agggagattc tttttctcta gtgttttaag tgatcctttg aagtaagtgt   2460

ggagagtctt gaatggcaag accaggagct gagtttaagc ttgtaatgga agcttgcatt   2520

gtgggatata taactgagga agcatattta tcctgaaggt attttgccag aaggtatcac   2580

ttgacctgga aaaggaatct atttagttca ggaaagataa aaagtttaga ggtatgtgaa   2640

ggaagcactt agaacttgca agcctgatgt cctatcaagt tatgtcttct gggtgacaga   2700

caaaatagct tgtcttatgg tggtgatgtg ttgcattttc actttggggt ctgtaagaaa   2760

ctgtcagtga aaatatgtac aattccttca atttccattc ttaacaactg taatgttgaa   2820

aaataagttg aaaagtcttt gggaccatac atgcaaaaac ggtgcctctg ttacttaatt   2880

atttaatatt ctataaatgt acccaatctg tccgcaccct tcccagtgat ggggcagtat   2940

gtctgaggaa gtataatttc agtactgggg tcggggagag gaggtgatgt ttctacattt   3000

ttattttttc tataaattgc aattggtctg tatgctggtt tattttgaaa tttatattgg   3060

tttcttttca agctggtgtc atctcctaga ctgtttcacc cagatgctag catttttttt   3120

ttttttgaga cagagtctca ctctgtcacc taggctggag ttgcagtggt ttgatctcgg   3180

ctcactgcaa cctccgactc ctgggttcaa gcaattcttc tgcctcagcc tcctgagtag   3240

ctgggattac agatgtgcac cagcacaccc ggctaatttt ttgtattttt agtagagaca   3300

gggtttcgcc atgttggcca ggctggtctt gaactcctgg ccttatgtga tccgcccacc   3360

ttggcttccc aaagtgctgg gattacaggc atgagccacc tcgcctggcc agatgctagc   3420

attttagatc aaacaattca ttttagatga attgttttgt ttcacaatca ttttaaatca   3480

ttttagaatg tacttcacat tattagttgt gttatggcat aaaggtacaa ccattcccta   3540

actccatctt ttattaatgc ttaagtttaa attatattct tccaatgcct aagctattcc   3600

ctagaattaa actgggcact tttggaagca gcaacagtaa cagcagcagc aaacttttcc   3660

tctcatattt tgggtgtatc aaaagttcta gacttttgaa gttatgattt cagtggccca   3720

ctttatttct aaggaagagt gtctactttg gaacgatact ttgcacatag taggaactca   3780

agaaatacat ttgaataatt ataattaact gtttagctat cttaatgaga atttgttgac   3840

aacaaaagat catccatcgc cttatgtgtg agtaagattg gagcctctat caagatttag   3900

tcaagttcag ttagattgat tctagaaaca aatatttatt tctttctttt acggggatgt   3960

gaataaggct tttccttaag gccttcattc tttaaacaaa caggttgaaa tggtatgttg   4020

taaaagagaa gacgggagag aggtatttag atgataagtg tacttcacaa aaatgccaaa   4080

gtttgaaaaa taggtatgtt tgttctaaat gtttaagtgc ttctctgtta ggttctgggg   4140

cttgcaatca tttgaattgt tctgtttcac aataaaggag attcactggg ttctgcattt   4200

tcaggattca atagaactgc tccattaaaa aaataatcct tagcaagcat tcgaatccta   4260

actgctttga tgcacttgcc ctcgggcacc tgtcatttcc aatatggtag gtgtcaaagt   4320

caaaagtatt tactgggaga aaaaagagag gagtggttgt agaagtctcc ctaaatcaga   4380

catgtcaagc aatcagccaa cgtggtgtat ttctcattca atattttagt gtgaattgag   4440

acactgagat aaagacatcg tgcagagata aatggggata cagttaaatg tagcaactct   4500

tgagttcatt ttttcccact gtagcaaaat taatgctttc tctttattga aataaattgc   4560

tcattcctcc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaagg                4608


<210>  2909
<211>  248
<212>  PRT
<213>  Homosapiens

<400>  2909

Met Gly Met Glu Arg Pro Ala Ala Arg Glu Pro His Gly Pro Asp Ala 
1               5                   10                  15      


Leu Arg Arg Phe Gln Gly Leu Leu Leu Asp Arg Arg Gly Arg Leu His 
            20                  25                  30          


Arg Gln Val Leu Arg Leu Arg Glu Val Ala Arg Arg Leu Glu Arg Leu 
        35                  40                  45              


Arg Arg Arg Ser Leu Val Ala Asn Val Ala Gly Ser Ser Leu Ser Ala 
    50                  55                  60                  


Thr Gly Ala Leu Ala Ala Ile Val Gly Leu Ser Leu Ser Pro Val Thr 
65                  70                  75                  80  


Leu Gly Thr Ser Leu Leu Val Ser Ala Val Gly Leu Gly Val Ala Thr 
                85                  90                  95      


Ala Gly Gly Ala Val Thr Ile Thr Ser Asp Leu Ser Leu Ile Phe Cys 
            100                 105                 110         


Asn Ser Arg Glu Leu Arg Arg Val Gln Glu Ile Ala Ala Thr Cys Gln 
        115                 120                 125             


Asp Gln Met Arg Glu Ile Leu Ser Cys Leu Glu Phe Phe Cys Arg Trp 
    130                 135                 140                 


Gln Gly Cys Gly Asp Arg Gln Leu Leu Gln Cys Gly Arg Asn Ala Ser 
145                 150                 155                 160 


Ile Ala Leu Tyr Asn Ser Val Tyr Phe Ile Val Phe Phe Gly Ser Arg 
                165                 170                 175     


Gly Phe Leu Ile Pro Arg Arg Ala Glu Gly Asp Thr Lys Val Ser Gln 
            180                 185                 190         


Ala Val Leu Lys Ala Lys Ile Gln Lys Leu Ala Glu Ser Leu Glu Ser 
        195                 200                 205             


Cys Thr Gly Ala Leu Asp Glu Leu Ser Glu Gln Leu Glu Ser Arg Val 
    210                 215                 220                 


Gln Leu Cys Thr Lys Ser Ser Arg Gly His Asp Leu Lys Ile Ser Ala 
225                 230                 235                 240 


Asp Gln Arg Ala Gly Leu Phe Phe 
                245             


<210>  2910
<211>  1836
<212>  DNA
<213>  Homosapiens

<400>  2910
acttccggag acctcacaca agatggcggc acccgaggaa cacgattctc cgaccgaagc     60

gtcccagccg attgtggaag aggaggaaac taaaacattt aaagacctgg gtgtgacaga    120

tgtgttgtgt gaagcttgtg accagttggg atggacaaaa cccaccaaga tccagattga    180

agctattcct ttggccttac aaggtcgtga tatcattggg cttgcagaaa ctggctctgg    240

aaagacaggc gcctttgctt tgcccattct aaacgcactg ctggagaccc cgcagcgttt    300

gtttgcccta gttcttaccc cgactcggga gctggccttt cagatctcag agcagtttga    360

agccctgggg tcctctattg gagtgcagag tgctgtgatt gtaggtggaa ttgattcaat    420

gtctcaatct ttggcccttg caaaaaaacc acatataata atagcaactc ctggtcgact    480

gattgaccac ttggaaaata cgaaaggttt caacttgaga gctctcaaat acttggtcat    540

ggatgaagcc gaccgaatac tgaatatgga ttttgagaca gaggttgaca agatcctcaa    600

agtgattcct cgagatcgga aaacattcct cttctctgcc accatgacca agaaggttca    660

aaaacttcag cgagcagctc tgaagaatcc tgtgaaatgt gccgtttcct ctaaatacca    720

gacagttgaa aaattacagc aatattatat ttttattccc tctaaattca aggataccta    780

cctggtttat attctaaatg aattggctgg aaactccttt atgatattct gcagcacctg    840

taataatacc cagagaacag ctttgctact gcgaaatctt ggcttcactg ccatccccct    900

ccatggacaa atgagtcaga gtaagcgcct aggatccctt aataagttta aggccaaggc    960

ccgttccatt cttctagcaa ctgacgttgc cagccgaggt ttggacatac ctcatgtaga   1020

tgtggttgtc aactttgaca ttcctaccca ttccaaggat tacatccatc gagtaggtcg   1080

aacagctaga gctgggcgct ccggaaaggc tattactttt gtcacacagt atgatgtgga   1140

actcttccag cgcatagaac acttaattgg gaagaaacta ccaggttttc caacacagga   1200

tgatgaggtt atgatgctga cagaacgcgt cgctgaagcc caaaggtttg cccgaatgga   1260

gttaagggag catggagaaa agaagaaacg ctcgcgagag gatgctggag ataatgatga   1320

cacagagggt gctattggtg tcaggaacaa ggtggctgga ggaaaaatga agaagcggaa   1380

aggccgttaa tcacttttat gaaggctcga gttctgctgt tctgtaaaag agaattggag   1440

aatgaaacct gctccaacag agatcatgag actgaaattg gtcagaattg tgtccagaat   1500

gtgctcagct aattcagtat tcttccccat tctgggttgg agtttactgc agagtaattc   1560

ttacagtgct gatgtcaaga ctgttactgt tcttcgactt tgattccttg ctcatgacat   1620

gagtagggtg tgctcttctg tcacttcaca cagacctttt gcctttttta gctgcaagtc   1680

aaggactagg ttgatgatgc ccatgacctg taattgtaaa gaagcttgga catctgcaaa   1740

tgatatttaa accatcttgg cttgtgcttt attcaaacta atgtgaaaca ataaatttaa   1800

atattatttt taaaagaaaa aaaaaaaaaa aaaaaa                             1836


<210>  2911
<211>  455
<212>  PRT
<213>  Homosapiens

<400>  2911

Met Ala Ala Pro Glu Glu His Asp Ser Pro Thr Glu Ala Ser Gln Pro 
1               5                   10                  15      


Ile Val Glu Glu Glu Glu Thr Lys Thr Phe Lys Asp Leu Gly Val Thr 
            20                  25                  30          


Asp Val Leu Cys Glu Ala Cys Asp Gln Leu Gly Trp Thr Lys Pro Thr 
        35                  40                  45              


Lys Ile Gln Ile Glu Ala Ile Pro Leu Ala Leu Gln Gly Arg Asp Ile 
    50                  55                  60                  


Ile Gly Leu Ala Glu Thr Gly Ser Gly Lys Thr Gly Ala Phe Ala Leu 
65                  70                  75                  80  


Pro Ile Leu Asn Ala Leu Leu Glu Thr Pro Gln Arg Leu Phe Ala Leu 
                85                  90                  95      


Val Leu Thr Pro Thr Arg Glu Leu Ala Phe Gln Ile Ser Glu Gln Phe 
            100                 105                 110         


Glu Ala Leu Gly Ser Ser Ile Gly Val Gln Ser Ala Val Ile Val Gly 
        115                 120                 125             


Gly Ile Asp Ser Met Ser Gln Ser Leu Ala Leu Ala Lys Lys Pro His 
    130                 135                 140                 


Ile Ile Ile Ala Thr Pro Gly Arg Leu Ile Asp His Leu Glu Asn Thr 
145                 150                 155                 160 


Lys Gly Phe Asn Leu Arg Ala Leu Lys Tyr Leu Val Met Asp Glu Ala 
                165                 170                 175     


Asp Arg Ile Leu Asn Met Asp Phe Glu Thr Glu Val Asp Lys Ile Leu 
            180                 185                 190         


Lys Val Ile Pro Arg Asp Arg Lys Thr Phe Leu Phe Ser Ala Thr Met 
        195                 200                 205             


Thr Lys Lys Val Gln Lys Leu Gln Arg Ala Ala Leu Lys Asn Pro Val 
    210                 215                 220                 


Lys Cys Ala Val Ser Ser Lys Tyr Gln Thr Val Glu Lys Leu Gln Gln 
225                 230                 235                 240 


Tyr Tyr Ile Phe Ile Pro Ser Lys Phe Lys Asp Thr Tyr Leu Val Tyr 
                245                 250                 255     


Ile Leu Asn Glu Leu Ala Gly Asn Ser Phe Met Ile Phe Cys Ser Thr 
            260                 265                 270         


Cys Asn Asn Thr Gln Arg Thr Ala Leu Leu Leu Arg Asn Leu Gly Phe 
        275                 280                 285             


Thr Ala Ile Pro Leu His Gly Gln Met Ser Gln Ser Lys Arg Leu Gly 
    290                 295                 300                 


Ser Leu Asn Lys Phe Lys Ala Lys Ala Arg Ser Ile Leu Leu Ala Thr 
305                 310                 315                 320 


Asp Val Ala Ser Arg Gly Leu Asp Ile Pro His Val Asp Val Val Val 
                325                 330                 335     


Asn Phe Asp Ile Pro Thr His Ser Lys Asp Tyr Ile His Arg Val Gly 
            340                 345                 350         


Arg Thr Ala Arg Ala Gly Arg Ser Gly Lys Ala Ile Thr Phe Val Thr 
        355                 360                 365             


Gln Tyr Asp Val Glu Leu Phe Gln Arg Ile Glu His Leu Ile Gly Lys 
    370                 375                 380                 


Lys Leu Pro Gly Phe Pro Thr Gln Asp Asp Glu Val Met Met Leu Thr 
385                 390                 395                 400 


Glu Arg Val Ala Glu Ala Gln Arg Phe Ala Arg Met Glu Leu Arg Glu 
                405                 410                 415     


His Gly Glu Lys Lys Lys Arg Ser Arg Glu Asp Ala Gly Asp Asn Asp 
            420                 425                 430         


Asp Thr Glu Gly Ala Ile Gly Val Arg Asn Lys Val Ala Gly Gly Lys 
        435                 440                 445             


Met Lys Lys Arg Lys Gly Arg 
    450                 455 


<210>  2912
<211>  1689
<212>  DNA
<213>  Homosapiens

<400>  2912
acttccggag acctcacaca agatggcggc acccgaggaa cacgattctc cgaccgaagc     60

gtcccagccg attgtggaag aggaggaaac taaaacattt aaagacctgg gtgtgacaga    120

tgtgttgtgt gaagcttgtg accagttggg atggacaaaa cccaccaaga tccagattga    180

agctattcct ttggccttac aaggtcgtga tatcattggg cttgcagaaa ctggctctgg    240

aaagacaggc gcctttgctt tgcccattct aaacgcactg ctggagaccc cgcagcgttt    300

gtttgcccta gttcttaccc cgactcggga gctggccttt cagatctcag agcagtttga    360

agccctgggg tcctctattg gagtgcagag tgctgtgatt gtaggtggaa ttgattcaat    420

gtctcaatct ttggcccttg caaaaaaacc acatataata atagcaactc ctggtcgact    480

gattgaccac ttggaaaata cgaaaggttt caacttgaga gctctcaaat acttggtcat    540

ggatgaagcc gaccgaatac tgaatatgga ttttgagaca gaggttgaca agatcctcaa    600

agtgattcct cgagatcgga aaacattcct cttctctgcc accatgacca agaaggttca    660

aaaacttcag cgagcagctc tgaagaatcc tgtgaaatgt gccgtttcct ctaaatacca    720

gacagttgaa aaattacagc aatattatat ttttattccc tctaaattca agagtaagcg    780

cctaggatcc cttaataagt ttaaggccaa ggcccgttcc attcttctag caactgacgt    840

tgccagccga ggtttggaca tacctcatgt agatgtggtt gtcaactttg acattcctac    900

ccattccaag gattacatcc atcgagtagg tcgaacagct agagctgggc gctccggaaa    960

ggctattact tttgtcacac agtatgatgt ggaactcttc cagcgcatag aacacttaat   1020

tgggaagaaa ctaccaggtt ttccaacaca ggatgatgag gttatgatgc tgacagaacg   1080

cgtcgctgaa gcccaaaggt ttgcccgaat ggagttaagg gagcatggag aaaagaagaa   1140

acgctcgcga gaggatgctg gagataatga tgacacagag ggtgctattg gtgtcaggaa   1200

caaggtggct ggaggaaaaa tgaagaagcg gaaaggccgt taatcacttt tatgaaggct   1260

cgagttctgc tgttctgtaa aagagaattg gagaatgaaa cctgctccaa cagagatcat   1320

gagactgaaa ttggtcagaa ttgtgtccag aatgtgctca gctaattcag tattcttccc   1380

cattctgggt tggagtttac tgcagagtaa ttcttacagt gctgatgtca agactgttac   1440

tgttcttcga ctttgattcc ttgctcatga catgagtagg gtgtgctctt ctgtcacttc   1500

acacagacct tttgcctttt ttagctgcaa gtcaaggact aggttgatga tgcccatgac   1560

ctgtaattgt aaagaagctt ggacatctgc aaatgatatt taaaccatct tggcttgtgc   1620

tttattcaaa ctaatgtgaa acaataaatt taaatattat ttttaaaaga aaaaaaaaaa   1680

aaaaaaaaa                                                           1689


<210>  2913
<211>  406
<212>  PRT
<213>  Homosapiens

<400>  2913

Met Ala Ala Pro Glu Glu His Asp Ser Pro Thr Glu Ala Ser Gln Pro 
1               5                   10                  15      


Ile Val Glu Glu Glu Glu Thr Lys Thr Phe Lys Asp Leu Gly Val Thr 
            20                  25                  30          


Asp Val Leu Cys Glu Ala Cys Asp Gln Leu Gly Trp Thr Lys Pro Thr 
        35                  40                  45              


Lys Ile Gln Ile Glu Ala Ile Pro Leu Ala Leu Gln Gly Arg Asp Ile 
    50                  55                  60                  


Ile Gly Leu Ala Glu Thr Gly Ser Gly Lys Thr Gly Ala Phe Ala Leu 
65                  70                  75                  80  


Pro Ile Leu Asn Ala Leu Leu Glu Thr Pro Gln Arg Leu Phe Ala Leu 
                85                  90                  95      


Val Leu Thr Pro Thr Arg Glu Leu Ala Phe Gln Ile Ser Glu Gln Phe 
            100                 105                 110         


Glu Ala Leu Gly Ser Ser Ile Gly Val Gln Ser Ala Val Ile Val Gly 
        115                 120                 125             


Gly Ile Asp Ser Met Ser Gln Ser Leu Ala Leu Ala Lys Lys Pro His 
    130                 135                 140                 


Ile Ile Ile Ala Thr Pro Gly Arg Leu Ile Asp His Leu Glu Asn Thr 
145                 150                 155                 160 


Lys Gly Phe Asn Leu Arg Ala Leu Lys Tyr Leu Val Met Asp Glu Ala 
                165                 170                 175     


Asp Arg Ile Leu Asn Met Asp Phe Glu Thr Glu Val Asp Lys Ile Leu 
            180                 185                 190         


Lys Val Ile Pro Arg Asp Arg Lys Thr Phe Leu Phe Ser Ala Thr Met 
        195                 200                 205             


Thr Lys Lys Val Gln Lys Leu Gln Arg Ala Ala Leu Lys Asn Pro Val 
    210                 215                 220                 


Lys Cys Ala Val Ser Ser Lys Tyr Gln Thr Val Glu Lys Leu Gln Gln 
225                 230                 235                 240 


Tyr Tyr Ile Phe Ile Pro Ser Lys Phe Lys Ser Lys Arg Leu Gly Ser 
                245                 250                 255     


Leu Asn Lys Phe Lys Ala Lys Ala Arg Ser Ile Leu Leu Ala Thr Asp 
            260                 265                 270         


Val Ala Ser Arg Gly Leu Asp Ile Pro His Val Asp Val Val Val Asn 
        275                 280                 285             


Phe Asp Ile Pro Thr His Ser Lys Asp Tyr Ile His Arg Val Gly Arg 
    290                 295                 300                 


Thr Ala Arg Ala Gly Arg Ser Gly Lys Ala Ile Thr Phe Val Thr Gln 
305                 310                 315                 320 


Tyr Asp Val Glu Leu Phe Gln Arg Ile Glu His Leu Ile Gly Lys Lys 
                325                 330                 335     


Leu Pro Gly Phe Pro Thr Gln Asp Asp Glu Val Met Met Leu Thr Glu 
            340                 345                 350         


Arg Val Ala Glu Ala Gln Arg Phe Ala Arg Met Glu Leu Arg Glu His 
        355                 360                 365             


Gly Glu Lys Lys Lys Arg Ser Arg Glu Asp Ala Gly Asp Asn Asp Asp 
    370                 375                 380                 


Thr Glu Gly Ala Ile Gly Val Arg Asn Lys Val Ala Gly Gly Lys Met 
385                 390                 395                 400 


Lys Lys Arg Lys Gly Arg 
                405     


<210>  2914
<211>  1899
<212>  DNA
<213>  Homosapiens

<400>  2914
ttccattact aatgcctgca attgctgata atagacgtgc cccaggaatc gctgcaaggg     60

aaatggagca agtcagggtc tccttctgtg gcccagtctg gaatgttagt ggtgcaatct    120

cgactcactg caacctccgc ctcccggatt caagtgattc tcctgcctca gcctcccaag    180

tagctgggat tacacgtacg caccaccatg cccggcaaat ttttgtattt ttagtagaga    240

tagggtttca acatattggc caggctggtc tcaaactcgt gacctcaagt gatctgcccg    300

cctcagcctc ccaaaatgct gggattatag gcgtgaacca tcacaccggg ccattccaat    360

cactcttcat ttcctgcatc tcaaagcaac gctgtcaaac agttggagtt gattttctag    420

gcctttctgt tttccccctc ctgcttgcca ttgcagggcc tcctctggtc actcgtacca    480

gtgagagatc aggctccttt aggaagtact cacagcggaa aatcagcttg aaactgcctt    540

tggaaaagta tgactgagac agtgaaggag atcaaactta actgactccc tcttgctcct    600

aacctccaga ctgtccttat tcattcctgg gtgtaggccg aactaacttt gggagaaact    660

tagtttatag tttaaacaaa gacggtaaca accctttctt aaagcagacc tccttcttgc    720

ctggggacta gattgccttt gtaggatgaa cattaaccac aagattagaa attatggttt    780

aggagtcatg cagctggagc tacaagattc caaccctccc ctaaactgct cctaagatca    840

gtgcttcttt cccaagcggc tgccgaagat ggcggaggta caggtcctgg tgcttgatgg    900

tcgaggccat ctcctgggcc acctggcggc catcgtggct aaacaggtac tgctgggccg    960

gaaggtggtg gttgtatgct gtgaaggcat caacatttct ggcaatttct acagaaacaa   1020

gttgaagtac ctggctttcc tccgcaagcg gatgaacagc aacccttccc gaggccccta   1080

ccccctccag gcccccagcc gcatcttctg gcagaccatg cgaggtatgc cgccccacaa   1140

gaccaagcca ggccaggccg ctctggactg cctcaaggtg tttgacggca tcccaccgcc   1200

ctacgacaag aaaaagcgga tggtggttcc tgctgccctc aaggttgtgc gtctgaagcc   1260

tgcaagaaag tttgcctatc tggggcgcct ggctcacgag gttggctgga agtaccaggc   1320

agtgacagcc accctggagg agaagaggaa agagaaagcc aagatccact accggaagaa   1380

gaaacagttc atgaggctat ggaaacaggc cgagaagaac gtggagaaga aaattgacaa   1440

atacacagaa gtcctcaaga cccacggact cctggtctga gcccaataaa gactgttaat   1500

tcctcaaaaa aaaaaaaaaa aaaaaaagat cagtggttga gatattctgc agaccctgca   1560

cttgatggat cagctggcac cacccagatc aataaactgg ctcatctgat cttgtggccc   1620

ccacccagaa ctgactctga aagaagacgg ctccgacttc ctacgatttc atctctaacc   1680

aatcagcact cctggctcac tggcttcccc tcatctgcca aattatcctt aaaaattctg   1740

ctccccaaat gctcagggag gctgatttga gtaagaataa aactccagtc tcctgcacag   1800

ctggctctgt gtgatttact ctttctctat tgcaatttcc ctgtcttgat gaattggtct   1860

gtctatgtag cgggcaaggt gaaccccttg agtggttac                          1899


<210>  2915
<211>  203
<212>  PRT
<213>  Homosapiens

<400>  2915

Met Ala Glu Val Gln Val Leu Val Leu Asp Gly Arg Gly His Leu Leu 
1               5                   10                  15      


Gly His Leu Ala Ala Ile Val Ala Lys Gln Val Leu Leu Gly Arg Lys 
            20                  25                  30          


Val Val Val Val Cys Cys Glu Gly Ile Asn Ile Ser Gly Asn Phe Tyr 
        35                  40                  45              


Arg Asn Lys Leu Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Ser 
    50                  55                  60                  


Asn Pro Ser Arg Gly Pro Tyr Pro Leu Gln Ala Pro Ser Arg Ile Phe 
65                  70                  75                  80  


Trp Gln Thr Met Arg Gly Met Pro Pro His Lys Thr Lys Pro Gly Gln 
                85                  90                  95      


Ala Ala Leu Asp Cys Leu Lys Val Phe Asp Gly Ile Pro Pro Pro Tyr 
            100                 105                 110         


Asp Lys Lys Lys Arg Met Val Val Pro Ala Ala Leu Lys Val Val Arg 
        115                 120                 125             


Leu Lys Pro Ala Arg Lys Phe Ala Tyr Leu Gly Arg Leu Ala His Glu 
    130                 135                 140                 


Val Gly Trp Lys Tyr Gln Ala Val Thr Ala Thr Leu Glu Glu Lys Arg 
145                 150                 155                 160 


Lys Glu Lys Ala Lys Ile His Tyr Arg Lys Lys Lys Gln Phe Met Arg 
                165                 170                 175     


Leu Trp Lys Gln Ala Glu Lys Asn Val Glu Lys Lys Ile Asp Lys Tyr 
            180                 185                 190         


Thr Glu Val Leu Lys Thr His Gly Leu Leu Val 
        195                 200             


<210>  2916
<211>  694
<212>  DNA
<213>  Homosapiens

<400>  2916
ttcagaaaaa gcggatggtg gttcctgctg ccctcaaggt tgtgcgtctg aagcctgcaa     60

gaaagtttgc ctatctgggg cgcctggctc acgaggttgg ctggaagtac caggcagtga    120

cagccaccct ggaggagaag aggaaagaga aagccaagat ccactaccgg aagaagaaac    180

agttcatgag gctatggaaa caggccgaga agaacgtgga gaagaaaatt gacaaataca    240

cagaagtcct caagacccac ggactcctgg tctgagccca ataaagactg ttaattcctc    300

aaaaaaaaaa aaaaaaaaaa aagatcagtg gttgagatat tctgcagacc ctgcacttga    360

tggatcagct ggcaccaccc agatcaataa actggctcat ctgatcttgt ggcccccacc    420

cagaactgac tctgaaagaa gacggctccg acttcctacg atttcatctc taaccaatca    480

gcactcctgg ctcactggct tcccctcatc tgccaaatta tccttaaaaa ttctgctccc    540

caaatgctca gggaggctga tttgagtaag aataaaactc cagtctcctg cacagctggc    600

tctgtgtgat ttactctttc tctattgcaa tttccctgtc ttgatgaatt ggtctgtcta    660

tgtagcgggc aaggtgaacc ccttgagtgg ttac                                694


<210>  2917
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  2917

Met Val Val Pro Ala Ala Leu Lys Val Val Arg Leu Lys Pro Ala Arg 
1               5                   10                  15      


Lys Phe Ala Tyr Leu Gly Arg Leu Ala His Glu Val Gly Trp Lys Tyr 
            20                  25                  30          


Gln Ala Val Thr Ala Thr Leu Glu Glu Lys Arg Lys Glu Lys Ala Lys 
        35                  40                  45              


Ile His Tyr Arg Lys Lys Lys Gln Phe Met Arg Leu Trp Lys Gln Ala 
    50                  55                  60                  


Glu Lys Asn Val Glu Lys Lys Ile Asp Lys Tyr Thr Glu Val Leu Lys 
65                  70                  75                  80  


Thr His Gly Leu Leu Val 
                85      


<210>  2918
<211>  1833
<212>  DNA
<213>  Homosapiens

<400>  2918
ttccattact aatgcctgca attgctgata atagacgtgc cccaggaatc gctgcaaggg     60

aaatggagca agtcagggtc tccttctgtg gcccagtctg gaatgttagt ggtgcaatct    120

cgactcactg caacctccgc ctcccggatt caagtgattc tcctgcctca gcctcccaag    180

tagctgggat tacacgtacg caccaccatg cccggcaaat ttttgtattt ttagtagaga    240

tagggtttca acatattggc caggctggtc tcaaactcgt gacctcaagt gatctgcccg    300

cctcagcctc ccaaaatgct gggattatag gcgtgaacca tcacaccggg ccattccaat    360

cactcttcat ttcctgcatc tcaaagcaac gctgtcaaac agttggagtt gattttctag    420

gcctttctgt tttccccctc ctgcttgcca ttgcagggcc tcctctggtc actcgtacca    480

gtgagagatc aggctccttt aggaagtact cacagcggaa aatcagcttg aaactgcctt    540

tggaaaagta tgactgagac agtgaaggag atcaaactta actgactccc tcttgctcct    600

aacctccaga ctgtccttat tcattcctgg gtgtaggccg aactaacttt gggagaaact    660

tagtttatag tttaaacaaa gacggtaaca accctttctt aaagcagacc tccttcttgc    720

ctggggacta gattgccttt gtaggatgaa cattaaccac aagattagaa attatggttt    780

aggagtcatg cagctggagc tacaagattc caaccctccc ctaaactgct cctaagatca    840

gtgcttcttt cccaagcggc tgccgaagat ggcggaggta caggtcctgg tgcttgatgg    900

tcgaggccat ctcctgggcc acctggcggc catcgtggct aaacaggtac tgctgggccg    960

gaaggtggtg gttgtatgct gtgaaggcat caacatttct ggcaatttct acagaaacaa   1020

gttgaagtac ctggctttcc tccgcaagcg gatgaacagc aacccttccc gaggccccta   1080

ccccctccag gcccccagcc gcatcttctg gcagaccatg cgaggtatgc cgccccacaa   1140

gaccaagcca ggccaggccg ctctggactg cctcaaggtt gtgcgtctga agcctgcaag   1200

aaagtttgcc tatctggggc gcctggctca cgaggttggc tggaagtacc aggcagtgac   1260

agccaccctg gaggagaaga ggaaagagaa agccaagatc cactaccgga agaagaaaca   1320

gttcatgagg ctatggaaac aggccgagaa gaacgtggag aagaaaattg acaaatacac   1380

agaagtcctc aagacccacg gactcctggt ctgagcccaa taaagactgt taattcctca   1440

aaaaaaaaaa aaaaaaaaaa agatcagtgg ttgagatatt ctgcagaccc tgcacttgat   1500

ggatcagctg gcaccaccca gatcaataaa ctggctcatc tgatcttgtg gcccccaccc   1560

agaactgact ctgaaagaag acggctccga cttcctacga tttcatctct aaccaatcag   1620

cactcctggc tcactggctt cccctcatct gccaaattat ccttaaaaat tctgctcccc   1680

aaatgctcag ggaggctgat ttgagtaaga ataaaactcc agtctcctgc acagctggct   1740

ctgtgtgatt tactctttct ctattgcaat ttccctgtct tgatgaattg gtctgtctat   1800

gtagcgggca aggtgaaccc cttgagtggt tac                                1833


<210>  2919
<211>  181
<212>  PRT
<213>  Homosapiens

<400>  2919

Met Ala Glu Val Gln Val Leu Val Leu Asp Gly Arg Gly His Leu Leu 
1               5                   10                  15      


Gly His Leu Ala Ala Ile Val Ala Lys Gln Val Leu Leu Gly Arg Lys 
            20                  25                  30          


Val Val Val Val Cys Cys Glu Gly Ile Asn Ile Ser Gly Asn Phe Tyr 
        35                  40                  45              


Arg Asn Lys Leu Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Ser 
    50                  55                  60                  


Asn Pro Ser Arg Gly Pro Tyr Pro Leu Gln Ala Pro Ser Arg Ile Phe 
65                  70                  75                  80  


Trp Gln Thr Met Arg Gly Met Pro Pro His Lys Thr Lys Pro Gly Gln 
                85                  90                  95      


Ala Ala Leu Asp Cys Leu Lys Val Val Arg Leu Lys Pro Ala Arg Lys 
            100                 105                 110         


Phe Ala Tyr Leu Gly Arg Leu Ala His Glu Val Gly Trp Lys Tyr Gln 
        115                 120                 125             


Ala Val Thr Ala Thr Leu Glu Glu Lys Arg Lys Glu Lys Ala Lys Ile 
    130                 135                 140                 


His Tyr Arg Lys Lys Lys Gln Phe Met Arg Leu Trp Lys Gln Ala Glu 
145                 150                 155                 160 


Lys Asn Val Glu Lys Lys Ile Asp Lys Tyr Thr Glu Val Leu Lys Thr 
                165                 170                 175     


His Gly Leu Leu Val 
            180     


<210>  2920
<211>  1831
<212>  DNA
<213>  Homosapiens

<400>  2920
ttccattact aatgcctgca attgctgata atagacgtgc cccaggaatc gctgcaaggg     60

aaatggagca agtcagggtc tccttctgtg gcccagtctg gaatgttagt ggtgcaatct    120

cgactcactg caacctccgc ctcccggatt caagtgattc tcctgcctca gcctcccaag    180

tagctgggat tacacgtacg caccaccatg cccggcaaat ttttgtattt ttagtagaga    240

tagggtttca acatattggc caggctggtc tcaaactcgt gacctcaagt gatctgcccg    300

cctcagcctc ccaaaatgct gggattatag gcgtgaacca tcacaccggg ccattccaat    360

cactcttcat ttcctgcatc tcaaagcaac gctgtcaaac agttggagtt gattttctag    420

gcctttctgt tttccccctc ctgcttgcca ttgcagggcc tcctctggtc actcgtacca    480

gtgagagatc aggctccttt aggaagtact cacagcggaa aatcagcttg aaactgcctt    540

tggaaaagta tgactgagac agtgaaggag atcaaactta actgactccc tcttgctcct    600

aacctccaga ctgtccttat tcattcctgg gtgtaggccg aactaacttt gggagaaact    660

tagtttatag tttaaacaaa gacggtaaca accctttctt aaagcagacc tccttcttgc    720

ctggggacta gattgccttt gtaggatgaa cattaaccac aagattagaa attatggttt    780

aggagtcatg cagctggagc tacaagattc caaccctccc ctaaactgct cctaagatca    840

gtgcttcttt cccaagcggc tgccgaagat ggcggaggta caggtcctgg tgcttgatgg    900

tcgaggccat ctcctgggcc acctggcggc catcgtggct aaacagaaac aagttgaagt    960

acctggcttt cctccgcaag cggatgaaca gcaacccttc ccgaggcccc taccccctcc   1020

aggcccccag ccgcatcttc tggcagacca tgcgaggtat gccgccccac aagaccaagc   1080

caggccaggc cgctctggac tgcctcaagg tgtttgacgg catcccaccg ccctacgaca   1140

agaaaaagcg gatggtggtt cctgctgccc tcaaggttgt gcgtctgaag cctgcaagaa   1200

agtttgccta tctggggcgc ctggctcacg aggttggctg gaagtaccag gcagtgacag   1260

ccaccctgga ggagaagagg aaagagaaag ccaagatcca ctaccggaag aagaaacagt   1320

tcatgaggct atggaaacag gccgagaaga acgtggagaa gaaaattgac aaatacacag   1380

aagtcctcaa gacccacgga ctcctggtct gagcccaata aagactgtta attcctcaaa   1440

aaaaaaaaaa aaaaaaaaag atcagtggtt gagatattct gcagaccctg cacttgatgg   1500

atcagctggc accacccaga tcaataaact ggctcatctg atcttgtggc ccccacccag   1560

aactgactct gaaagaagac ggctccgact tcctacgatt tcatctctaa ccaatcagca   1620

ctcctggctc actggcttcc cctcatctgc caaattatcc ttaaaaattc tgctccccaa   1680

atgctcaggg aggctgattt gagtaagaat aaaactccag tctcctgcac agctggctct   1740

gtgtgattta ctctttctct attgcaattt ccctgtcttg atgaattggt ctgtctatgt   1800

agcgggcaag gtgaacccct tgagtggtta c                                  1831


<210>  2921
<211>  171
<212>  PRT
<213>  Homosapiens

<400>  2921

Met Val Glu Ala Ile Ser Trp Ala Thr Trp Arg Pro Ser Trp Leu Asn 
1               5                   10                  15      


Arg Asn Lys Leu Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Ser 
            20                  25                  30          


Asn Pro Ser Arg Gly Pro Tyr Pro Leu Gln Ala Pro Ser Arg Ile Phe 
        35                  40                  45              


Trp Gln Thr Met Arg Gly Met Pro Pro His Lys Thr Lys Pro Gly Gln 
    50                  55                  60                  


Ala Ala Leu Asp Cys Leu Lys Val Phe Asp Gly Ile Pro Pro Pro Tyr 
65                  70                  75                  80  


Asp Lys Lys Lys Arg Met Val Val Pro Ala Ala Leu Lys Val Val Arg 
                85                  90                  95      


Leu Lys Pro Ala Arg Lys Phe Ala Tyr Leu Gly Arg Leu Ala His Glu 
            100                 105                 110         


Val Gly Trp Lys Tyr Gln Ala Val Thr Ala Thr Leu Glu Glu Lys Arg 
        115                 120                 125             


Lys Glu Lys Ala Lys Ile His Tyr Arg Lys Lys Lys Gln Phe Met Arg 
    130                 135                 140                 


Leu Trp Lys Gln Ala Glu Lys Asn Val Glu Lys Lys Ile Asp Lys Tyr 
145                 150                 155                 160 


Thr Glu Val Leu Lys Thr His Gly Leu Leu Val 
                165                 170     


<210>  2922
<211>  1054
<212>  DNA
<213>  Homosapiens

<400>  2922
gaaaccttct cagaggagga gatatggcgg aggtacaggt cctggtgctt gatggtcgag     60

gccatctcct gggccacctg gcggccatcg tggctaaaca ggtactgctg ggccggaagg    120

tggtggttgt atgctgtgaa ggcatcaaca tttctggcaa tttctacaga aacaagttga    180

agtacctggc tttcctccgc aagcggatga acagcaaccc ttcccgaggc ccctaccccc    240

tccaggcccc cagccgcatc ttctggcaga ccatgcgagg tatgccgccc cacaagacca    300

agccaggcca ggccgctctg gactgcctca aggtgtttga cggcatccca ccgccctacg    360

acaagaaaaa gcggatggtg gttcctgctg ccctcaaggt tgtgcgtctg aagcctgcaa    420

gaaagtttgc ctatctgggg cgcctggctc acgaggttgg ctggaagtac caggcagtga    480

cagccaccct ggaggagaag aggaaagaga aagccaagat ccactaccgg aagaagaaac    540

agttcatgag gctatggaaa caggccgaga agaacgtgga gaagaaaatt gacaaataca    600

cagaagtcct caagacccac ggactcctgg tctgagccca ataaagactg ttaattcctc    660

aaaaaaaaaa aaaaaaaaaa aagatcagtg gttgagatat tctgcagacc ctgcacttga    720

tggatcagct ggcaccaccc agatcaataa actggctcat ctgatcttgt ggcccccacc    780

cagaactgac tctgaaagaa gacggctccg acttcctacg atttcatctc taaccaatca    840

gcactcctgg ctcactggct tcccctcatc tgccaaatta tccttaaaaa ttctgctccc    900

caaatgctca gggaggctga tttgagtaag aataaaactc cagtctcctg cacagctggc    960

tctgtgtgat ttactctttc tctattgcaa tttccctgtc ttgatgaatt ggtctgtcta   1020

tgtagcgggc aaggtgaacc ccttgagtgg ttac                               1054


<210>  2923
<211>  203
<212>  PRT
<213>  Homosapiens

<400>  2923

Met Ala Glu Val Gln Val Leu Val Leu Asp Gly Arg Gly His Leu Leu 
1               5                   10                  15      


Gly His Leu Ala Ala Ile Val Ala Lys Gln Val Leu Leu Gly Arg Lys 
            20                  25                  30          


Val Val Val Val Cys Cys Glu Gly Ile Asn Ile Ser Gly Asn Phe Tyr 
        35                  40                  45              


Arg Asn Lys Leu Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Ser 
    50                  55                  60                  


Asn Pro Ser Arg Gly Pro Tyr Pro Leu Gln Ala Pro Ser Arg Ile Phe 
65                  70                  75                  80  


Trp Gln Thr Met Arg Gly Met Pro Pro His Lys Thr Lys Pro Gly Gln 
                85                  90                  95      


Ala Ala Leu Asp Cys Leu Lys Val Phe Asp Gly Ile Pro Pro Pro Tyr 
            100                 105                 110         


Asp Lys Lys Lys Arg Met Val Val Pro Ala Ala Leu Lys Val Val Arg 
        115                 120                 125             


Leu Lys Pro Ala Arg Lys Phe Ala Tyr Leu Gly Arg Leu Ala His Glu 
    130                 135                 140                 


Val Gly Trp Lys Tyr Gln Ala Val Thr Ala Thr Leu Glu Glu Lys Arg 
145                 150                 155                 160 


Lys Glu Lys Ala Lys Ile His Tyr Arg Lys Lys Lys Gln Phe Met Arg 
                165                 170                 175     


Leu Trp Lys Gln Ala Glu Lys Asn Val Glu Lys Lys Ile Asp Lys Tyr 
            180                 185                 190         


Thr Glu Val Leu Lys Thr His Gly Leu Leu Val 
        195                 200             


<210>  2924
<211>  1053
<212>  DNA
<213>  Homosapiens

<400>  2924
ttttttccag cggctgccga agatggcgga ggtacaggtc ctggtgcttg atggtcgagg     60

ccatctcctg ggccacctgg cggccatcgt ggctaaacag gtactgctgg gccggaaggt    120

ggtggttgta tgctgtgaag gcatcaacat ttctggcaat ttctacagaa acaagttgaa    180

gtacctggct ttcctccgca agcggatgaa cagcaaccct tcccgaggcc cctaccccct    240

ccaggccccc agccgcatct tctggcagac catgcgaggt atgccgcccc acaagaccaa    300

gccaggccag gccgctctgg actgcctcaa ggtgtttgac ggcatcccac cgccctacga    360

caagaaaaag cggatggtgg ttcctgctgc cctcaaggtt gtgcgtctga agcctgcaag    420

aaagtttgcc tatctggggc gcctggctca cgaggttggc tggaagtacc aggcagtgac    480

agccaccctg gaggagaaga ggaaagagaa agccaagatc cactaccgga agaagaaaca    540

gttcatgagg ctatggaaac aggccgagaa gaacgtggag aagaaaattg acaaatacac    600

agaagtcctc aagacccacg gactcctggt ctgagcccaa taaagactgt taattcctca    660

aaaaaaaaaa aaaaaaaaaa agatcagtgg ttgagatatt ctgcagaccc tgcacttgat    720

ggatcagctg gcaccaccca gatcaataaa ctggctcatc tgatcttgtg gcccccaccc    780

agaactgact ctgaaagaag acggctccga cttcctacga tttcatctct aaccaatcag    840

cactcctggc tcactggctt cccctcatct gccaaattat ccttaaaaat tctgctcccc    900

aaatgctcag ggaggctgat ttgagtaaga ataaaactcc agtctcctgc acagctggct    960

ctgtgtgatt tactctttct ctattgcaat ttccctgtct tgatgaattg gtctgtctat   1020

gtagcgggca aggtgaaccc cttgagtggt tac                                1053


<210>  2925
<211>  203
<212>  PRT
<213>  Homosapiens

<400>  2925

Met Ala Glu Val Gln Val Leu Val Leu Asp Gly Arg Gly His Leu Leu 
1               5                   10                  15      


Gly His Leu Ala Ala Ile Val Ala Lys Gln Val Leu Leu Gly Arg Lys 
            20                  25                  30          


Val Val Val Val Cys Cys Glu Gly Ile Asn Ile Ser Gly Asn Phe Tyr 
        35                  40                  45              


Arg Asn Lys Leu Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Ser 
    50                  55                  60                  


Asn Pro Ser Arg Gly Pro Tyr Pro Leu Gln Ala Pro Ser Arg Ile Phe 
65                  70                  75                  80  


Trp Gln Thr Met Arg Gly Met Pro Pro His Lys Thr Lys Pro Gly Gln 
                85                  90                  95      


Ala Ala Leu Asp Cys Leu Lys Val Phe Asp Gly Ile Pro Pro Pro Tyr 
            100                 105                 110         


Asp Lys Lys Lys Arg Met Val Val Pro Ala Ala Leu Lys Val Val Arg 
        115                 120                 125             


Leu Lys Pro Ala Arg Lys Phe Ala Tyr Leu Gly Arg Leu Ala His Glu 
    130                 135                 140                 


Val Gly Trp Lys Tyr Gln Ala Val Thr Ala Thr Leu Glu Glu Lys Arg 
145                 150                 155                 160 


Lys Glu Lys Ala Lys Ile His Tyr Arg Lys Lys Lys Gln Phe Met Arg 
                165                 170                 175     


Leu Trp Lys Gln Ala Glu Lys Asn Val Glu Lys Lys Ile Asp Lys Tyr 
            180                 185                 190         


Thr Glu Val Leu Lys Thr His Gly Leu Leu Val 
        195                 200             


<210>  2926
<211>  1047
<212>  DNA
<213>  Homosapiens

<400>  2926
ggcacggctg ccgaagatgg cggaggtaca ggtcctggtg cttgatggtc gaggccatct     60

cctgggccac ctggcggcca tcgtggctaa acaggtactg ctgggccgga aggtggtggt    120

tgtatgctgt gaaggcatca acatttctgg caatttctac agaaacaagt tgaagtacct    180

ggctttcctc cgcaagcgga tgaacagcaa cccttcccga ggcccctacc ccctccaggc    240

ccccagccgc atcttctggc agaccatgcg aggtatgccg ccccacaaga ccaagccagg    300

ccaggccgct ctggactgcc tcaaggtgtt tgacggcatc ccaccgccct acgacaagaa    360

aaagcggatg gtggttcctg ctgccctcaa ggttgtgcgt ctgaagcctg caagaaagtt    420

tgcctatctg gggcgcctgg ctcacgaggt tggctggaag taccaggcag tgacagccac    480

cctggaggag aagaggaaag agaaagccaa gatccactac cggaagaaga aacagttcat    540

gaggctatgg aaacaggccg agaagaacgt ggagaagaaa attgacaaat acacagaagt    600

cctcaagacc cacggactcc tggtctgagc ccaataaaga ctgttaattc ctcaaaaaaa    660

aaaaaaaaaa aaaaagatca gtggttgaga tattctgcag accctgcact tgatggatca    720

gctggcacca cccagatcaa taaactggct catctgatct tgtggccccc acccagaact    780

gactctgaaa gaagacggct ccgacttcct acgatttcat ctctaaccaa tcagcactcc    840

tggctcactg gcttcccctc atctgccaaa ttatccttaa aaattctgct ccccaaatgc    900

tcagggaggc tgatttgagt aagaataaaa ctccagtctc ctgcacagct ggctctgtgt    960

gatttactct ttctctattg caatttccct gtcttgatga attggtctgt ctatgtagcg   1020

ggcaaggtga accccttgag tggttac                                       1047


<210>  2927
<211>  203
<212>  PRT
<213>  Homosapiens

<400>  2927

Met Ala Glu Val Gln Val Leu Val Leu Asp Gly Arg Gly His Leu Leu 
1               5                   10                  15      


Gly His Leu Ala Ala Ile Val Ala Lys Gln Val Leu Leu Gly Arg Lys 
            20                  25                  30          


Val Val Val Val Cys Cys Glu Gly Ile Asn Ile Ser Gly Asn Phe Tyr 
        35                  40                  45              


Arg Asn Lys Leu Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Ser 
    50                  55                  60                  


Asn Pro Ser Arg Gly Pro Tyr Pro Leu Gln Ala Pro Ser Arg Ile Phe 
65                  70                  75                  80  


Trp Gln Thr Met Arg Gly Met Pro Pro His Lys Thr Lys Pro Gly Gln 
                85                  90                  95      


Ala Ala Leu Asp Cys Leu Lys Val Phe Asp Gly Ile Pro Pro Pro Tyr 
            100                 105                 110         


Asp Lys Lys Lys Arg Met Val Val Pro Ala Ala Leu Lys Val Val Arg 
        115                 120                 125             


Leu Lys Pro Ala Arg Lys Phe Ala Tyr Leu Gly Arg Leu Ala His Glu 
    130                 135                 140                 


Val Gly Trp Lys Tyr Gln Ala Val Thr Ala Thr Leu Glu Glu Lys Arg 
145                 150                 155                 160 


Lys Glu Lys Ala Lys Ile His Tyr Arg Lys Lys Lys Gln Phe Met Arg 
                165                 170                 175     


Leu Trp Lys Gln Ala Glu Lys Asn Val Glu Lys Lys Ile Asp Lys Tyr 
            180                 185                 190         


Thr Glu Val Leu Lys Thr His Gly Leu Leu Val 
        195                 200             


<210>  2928
<211>  2856
<212>  DNA
<213>  Homosapiens

<400>  2928
gcttcccata cggcagtggc tgggggagag tgatggagag aaaggctaag ctaaggtcaa     60

agaaagtgga ggaaggctgg cttgtcccgc tggacttgac ggcggagctg ctgcaatctc    120

gcgggctggg cccttgcccc gggtggaccc gagtgcctgc ggggaggcgg gtgtggctcc    180

cccgggaggt gacagctggc ggggcccgta aggagctggt ctgctccggc tcccctctcg    240

tagccggcgc cctgggacca gcgcgtgagc acgtctcgga ggagtccgat gcgctgggca    300

gggccgggtg gtcacccccg cccagcttcc aggggtgact gtgcctctga cgtcagacgg    360

tttttgggtc attccctggc acggggactt tattttcata acagcatgaa gtgccgtgga    420

actggaatag gcgtgtcctc tccctcgacc ctccccctcc ttgtccctct gctcacccct    480

cgctcgttcc ctccctccgg cgagggccgc ctttataaca actgctcaga gtgcgagggc    540

gggatagctg tccaaggtct cccccagcac tgaggagctc gcctgctgcc ctcttgcgcg    600

cgggaagcag caccaagttc acggccaacg ccttggcact agggtccaga atggctacaa    660

cagtccctga tggttgccgc aatggcctga aatccaagta ctacagactt tgtgataagg    720

ctgaagcttg gggcatcgtc ctagaaacgg tggccacagc cggggttgtg acctcggtgg    780

ccttcatgct cactctcccg atcctcgtct gcaaggtgca ggactccaac aggcgaaaaa    840

tgctgcctac tcagtttctc ttcctcctgg gtgtgttggg catctttggc ctcaccttcg    900

ccttcatcat cggactggac gggagcacag ggcccacacg cttcttcctc tttgggatcc    960

tcttttccat ctgcttctcc tgcctgctgg ctcatgctgt cagtctgacc aagctcgtcc   1020

gggggaggaa gcccctttcc ctgttggtga ttctgggtct ggccgtgggc ttcagcctag   1080

tccaggatgt tatcgctatt gaatatattg tcctgaccat gaataggacc aacgtcaatg   1140

tcttttctga gctttccgct cctcgtcgca atgaagactt tgtcctcctg ctcacctacg   1200

tcctcttctt gatggcgctg accttcctca tgtcctcctt caccttctgt ggttccttca   1260

cgggctggaa gagacatggg gcccacatct acctcacgat gctcctctcc attgccatct   1320

gggtggcctg gatcaccctg ctcatgcttc ctgactttga ccgcaggtgg gatgacacca   1380

tcctcagctc cgccttggct gccaatggct gggtgttcct gttggcttat gttagtcccg   1440

agttttggct gctcacaaag caacgaaacc ccatggatta tcctgttgag gatgctttct   1500

gtaaacctca actcgtgaag aagagctatg gtgtggagaa cagagcctac tctcaagagg   1560

aaatcactca aggttttgaa gagacagggg acacgctcta tgccccctat tccacacatt   1620

ttcagctgca gaaccagcct ccccaaaagg aattctccat cccacgggcc cacgcttggc   1680

cgagccctta caaagactat gaagtaaaga aagagggcag ctaactctgt cctgaagagt   1740

gggacaaatg cagccgggcg gcagatctag cgggagctca aagggatgtg ggcgaaatct   1800

tgagtcttct gagaaaactg tacaagacac tacgggaaca gtttgcctcc ctcccagcct   1860

caaccacaat tcttccatgc tggggctgat gtgggctagt aagactccag ttcttagagg   1920

cgctgtagta tttttttttt tttgtctcat cctttggata cttcttttaa gtgggagtct   1980

caggcaactc aagtttagac ccttactctt tttgtttgtt ttttgaaaca ggatcttgct   2040

ctgtcaccca ggcttgagtg cagtggtgcg atcacagccc agtgcagcct cgaccacctg   2100

tgctcaagca atcctcccat ctccatctcc caaagtgctg ggatgacagg cgtgagccac   2160

agctcccagc ctaggccctt aatcttgctg ttattttcca tggactaaag gtctggtcat   2220

ctgagctcac gctggctcac acagctctag gggcctgctc ctctaactca cagtgggttt   2280

tgtgaggctc tgtggcccag agcagacctg catatctgag caaaaatagc aaaagcctct   2340

ctcagcccac tggcctgaat ctacactgga agccaacttg ctggcacccc cgctccccaa   2400

cccttcttgc ctgggtagga gaggctaaag atcaccctaa atttactcat ctctctagtg   2460

ctgcctcaca ttgggcctca gcagctcccc agcaccaatt cacaggtcac ccctctcttc   2520

ttgcactgtc cccaaacttg ctgtcaattc cgagatctaa tctcccccta cgctctgcca   2580

ggaattcttt cagacctcac tagcacaagc ccggttgctc cttgtcagga gaatttgtag   2640

atcattctca cttcaaattc ctggggctga tacttctctc atcttgcacc ccaacctctg   2700

taaatagatt taccgcattt acggctgcat tctgtaagtg ggcatggtct cctaatggag   2760

gagtgttcat tgtataataa gttattcacc tgagtatgca ataaagatgt ggtggccact   2820

ctttcatggt ggtggcagca gttaccagta aaaaaa                             2856


<210>  2929
<211>  357
<212>  PRT
<213>  Homosapiens

<400>  2929

Met Ala Thr Thr Val Pro Asp Gly Cys Arg Asn Gly Leu Lys Ser Lys 
1               5                   10                  15      


Tyr Tyr Arg Leu Cys Asp Lys Ala Glu Ala Trp Gly Ile Val Leu Glu 
            20                  25                  30          


Thr Val Ala Thr Ala Gly Val Val Thr Ser Val Ala Phe Met Leu Thr 
        35                  40                  45              


Leu Pro Ile Leu Val Cys Lys Val Gln Asp Ser Asn Arg Arg Lys Met 
    50                  55                  60                  


Leu Pro Thr Gln Phe Leu Phe Leu Leu Gly Val Leu Gly Ile Phe Gly 
65                  70                  75                  80  


Leu Thr Phe Ala Phe Ile Ile Gly Leu Asp Gly Ser Thr Gly Pro Thr 
                85                  90                  95      


Arg Phe Phe Leu Phe Gly Ile Leu Phe Ser Ile Cys Phe Ser Cys Leu 
            100                 105                 110         


Leu Ala His Ala Val Ser Leu Thr Lys Leu Val Arg Gly Arg Lys Pro 
        115                 120                 125             


Leu Ser Leu Leu Val Ile Leu Gly Leu Ala Val Gly Phe Ser Leu Val 
    130                 135                 140                 


Gln Asp Val Ile Ala Ile Glu Tyr Ile Val Leu Thr Met Asn Arg Thr 
145                 150                 155                 160 


Asn Val Asn Val Phe Ser Glu Leu Ser Ala Pro Arg Arg Asn Glu Asp 
                165                 170                 175     


Phe Val Leu Leu Leu Thr Tyr Val Leu Phe Leu Met Ala Leu Thr Phe 
            180                 185                 190         


Leu Met Ser Ser Phe Thr Phe Cys Gly Ser Phe Thr Gly Trp Lys Arg 
        195                 200                 205             


His Gly Ala His Ile Tyr Leu Thr Met Leu Leu Ser Ile Ala Ile Trp 
    210                 215                 220                 


Val Ala Trp Ile Thr Leu Leu Met Leu Pro Asp Phe Asp Arg Arg Trp 
225                 230                 235                 240 


Asp Asp Thr Ile Leu Ser Ser Ala Leu Ala Ala Asn Gly Trp Val Phe 
                245                 250                 255     


Leu Leu Ala Tyr Val Ser Pro Glu Phe Trp Leu Leu Thr Lys Gln Arg 
            260                 265                 270         


Asn Pro Met Asp Tyr Pro Val Glu Asp Ala Phe Cys Lys Pro Gln Leu 
        275                 280                 285             


Val Lys Lys Ser Tyr Gly Val Glu Asn Arg Ala Tyr Ser Gln Glu Glu 
    290                 295                 300                 


Ile Thr Gln Gly Phe Glu Glu Thr Gly Asp Thr Leu Tyr Ala Pro Tyr 
305                 310                 315                 320 


Ser Thr His Phe Gln Leu Gln Asn Gln Pro Pro Gln Lys Glu Phe Ser 
                325                 330                 335     


Ile Pro Arg Ala His Ala Trp Pro Ser Pro Tyr Lys Asp Tyr Glu Val 
            340                 345                 350         


Lys Lys Glu Gly Ser 
        355         


<210>  2930
<211>  1038
<212>  DNA
<213>  Homosapiens

<400>  2930
atgtacaagg actgcatcga gtccactgga gactattttc ttctctgtga cgccgagggg     60

ccatggggca tcattctgga gtccctggcc atacttggca tcgtggtcac aattctgcta    120

ctcttagcat ttctcttcct catgcgaaag atccaagact gcagccagtg gaatgtcctc    180

cccacccagc tcctcttcct cctgagtgtc ctggggctct tcggactcgc ttttgccttc    240

atcatcgagc tcaatcaaca aactgccccc gtacgctact ttctctttgg ggttctcttt    300

gctctctgtt tctcatgcct cttagctcat gcctccaatc tagtgaagct ggttcggggt    360

tgtgtctcct tctcctggac gacaattctg tgcattgcta ttggttgcag tctgttgcaa    420

atcattattg ccactgagta tgtgactctc atcatgacca gaggtatgat gtttgtgaat    480

atgacaccct gccagctcaa tgtggacttt gttgtactcc tggtctatgt cctcttcctg    540

atggccctca cattcttcgt ctccaaagcc accttctgtg gcccgtgtga gaactggaag    600

cagcatggaa ggctcatctt tatcactgtg ctcttctcca tcatcatctg ggtggtgtgg    660

atctccatgc tcctgagagg caacccgcag ttccagcgac agccccagtg ggacgacccg    720

gtcgtctgca ttgctctggt caccaacgca tgggttttcc tgctgctgta catcgtccct    780

gagctctgca ttctctacag atcgtgtaga caggagtgcc ctttacaagg caatgcctgc    840

cccgtcacag cctaccaaca cagcttccaa gtggagaacc aggagctctc cagagcccga    900

gacagtgatg gagctgagga ggatgtagca ttaacttcat atggtactcc cattcagccg    960

cagactgttg atcccacaca agagtgtttc atcccacagg ctaaactaag cccccagcaa   1020

gatgcaggag gagtataa                                                 1038


<210>  2931
<211>  345
<212>  PRT
<213>  Homosapiens

<400>  2931

Met Tyr Lys Asp Cys Ile Glu Ser Thr Gly Asp Tyr Phe Leu Leu Cys 
1               5                   10                  15      


Asp Ala Glu Gly Pro Trp Gly Ile Ile Leu Glu Ser Leu Ala Ile Leu 
            20                  25                  30          


Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe Leu Phe Leu Met 
        35                  40                  45              


Arg Lys Ile Gln Asp Cys Ser Gln Trp Asn Val Leu Pro Thr Gln Leu 
    50                  55                  60                  


Leu Phe Leu Leu Ser Val Leu Gly Leu Phe Gly Leu Ala Phe Ala Phe 
65                  70                  75                  80  


Ile Ile Glu Leu Asn Gln Gln Thr Ala Pro Val Arg Tyr Phe Leu Phe 
                85                  90                  95      


Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ala His Ala Ser 
            100                 105                 110         


Asn Leu Val Lys Leu Val Arg Gly Cys Val Ser Phe Ser Trp Thr Thr 
        115                 120                 125             


Ile Leu Cys Ile Ala Ile Gly Cys Ser Leu Leu Gln Ile Ile Ile Ala 
    130                 135                 140                 


Thr Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Met Met Phe Val Asn 
145                 150                 155                 160 


Met Thr Pro Cys Gln Leu Asn Val Asp Phe Val Val Leu Leu Val Tyr 
                165                 170                 175     


Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser Lys Ala Thr Phe 
            180                 185                 190         


Cys Gly Pro Cys Glu Asn Trp Lys Gln His Gly Arg Leu Ile Phe Ile 
        195                 200                 205             


Thr Val Leu Phe Ser Ile Ile Ile Trp Val Val Trp Ile Ser Met Leu 
    210                 215                 220                 


Leu Arg Gly Asn Pro Gln Phe Gln Arg Gln Pro Gln Trp Asp Asp Pro 
225                 230                 235                 240 


Val Val Cys Ile Ala Leu Val Thr Asn Ala Trp Val Phe Leu Leu Leu 
                245                 250                 255     


Tyr Ile Val Pro Glu Leu Cys Ile Leu Tyr Arg Ser Cys Arg Gln Glu 
            260                 265                 270         


Cys Pro Leu Gln Gly Asn Ala Cys Pro Val Thr Ala Tyr Gln His Ser 
        275                 280                 285             


Phe Gln Val Glu Asn Gln Glu Leu Ser Arg Ala Arg Asp Ser Asp Gly 
    290                 295                 300                 


Ala Glu Glu Asp Val Ala Leu Thr Ser Tyr Gly Thr Pro Ile Gln Pro 
305                 310                 315                 320 


Gln Thr Val Asp Pro Thr Gln Glu Cys Phe Ile Pro Gln Ala Lys Leu 
                325                 330                 335     


Ser Pro Gln Gln Asp Ala Gly Gly Val 
            340                 345 


<210>  2932
<211>  6240
<212>  DNA
<213>  Homosapiens

<400>  2932
ttgaatttgc atctcttcaa gacacaagat taaaacaaaa tttacgctaa attggatttt     60

aaattatctt ccgttcattt atccttcgtc tttcttatgt ggatatgcaa gcgagaagaa    120

gggactggac attcccaaca tgctcactcc cttaatctgt ccgtctagag gtttggcttc    180

tacaaaccaa gggagtcgac gagttgaaga tgaagcccag agcggagtgc tgttctccca    240

agttctggtt ggtgttggcc gtcctggccg tgtcaggcag cagagctcgt tctcagaaga    300

gcccccccag cattggcatt gctgtcatcc tcgtgggcac ttccgacgag gtggccatca    360

aggatgccca cgagaaagat gatttccacc atctctccgt ggtaccccgg gtggaactgg    420

tagccatgaa tgagaccgac ccaaagagca tcatcacccg catctgtgat ctcatgtctg    480

accggaagat ccagggggtg gtgtttgctg atgacacaga ccaggaagcc atcgcccaga    540

tcctcgattt catttcagca cagactctca ccccgatcct gggcatccac gggggctcct    600

ctatgataat ggcagataag gatgaatcct ccatgttctt ccagtttggc ccatcaattg    660

aacagcaagc ttccgtaatg ctcaacatca tggaagaata tgactggtac atcttttcta    720

tcgtcaccac ctatttccct ggctaccagg actttgtaaa caagatccgc agcaccattg    780

agaatagctt tgtgggctgg gagctagagg aggtcctcct actggacatg tccctggacg    840

atggagattc taagatccag aatcagctca agaaacttca aagccccatc attcttcttt    900

actgtaccaa ggaagaagcc acctacatct ttgaagtggc caactcagta gggctgactg    960

gctatggcta cacgtggatc gtgcccagtc tggtggcagg ggatacagac acagtgcctg   1020

cggagttccc cactgggctc atctctgtat catatgatga atgggactat ggcctccccg   1080

ccagagtgag agatggaatt gccataatca ccactgctgc ttctgacatg ctgtctgagc   1140

acagcttcat ccctgagccc aaaagcagtt gttacaacac ccacgagaag agaatctacc   1200

agtccaatat gctaaatagg tatctgatca atgtcacttt tgaggggagg aatttgtcct   1260

tcagtgaaga tggctaccag atgcacccga aactggtgat aattcttctg aacaaggaga   1320

ggaagtggga aagggtgggg aagtggaaag acaagtccct gcagatgaag tactatgtgt   1380

ggccccgaat gtgtccagag actgaagagc aggaggatga ccatctgagc attgtgaccc   1440

tggaggaggc accatttgtc attgtggaaa gtgtggaccc tctgagtgga acctgcatga   1500

ggaacacagt cccctgccaa aaacgcatag tcactgagaa taaaacagac gaggagccgg   1560

gttacatcaa aaaatgctgc aaggggttct gtattgacat ccttaagaaa atttctaaat   1620

ctgtgaagtt cacctatgac ctttacctgg ttaccaatgg caagcatggg aagaaaatca   1680

atggaacctg gaatggtatg attggagagg tggtcatgaa gagggcctac atggcagtgg   1740

gctcactcac catcaatgag gaacgatcgg aggtggtcga cttctctgtg cccttcatag   1800

agacaggcat cagtgtcatg gtgtcacgca gcaatgggac tgtctcacct tctgccttct   1860

tagagccatt cagcgctgac gtatgggtga tgatgtttgt gatgctgctc atcgtctcag   1920

ccgtggctgt ctttgtcttt gagtacttca gccctgtggg ttataacagg tgcctcgctg   1980

atggcagaga gcctggtgga ccctctttca ccatcggcaa agctatttgg ttgctctggg   2040

gtctggtgtt taacaactcc gtacctgtgc agaacccaaa ggggaccacc tccaagatca   2100

tggtgtcagt gtgggccttc tttgctgtca tcttcctggc cagctacact gccaacttag   2160

ctgccttcat gatccaagag gaatatgtgg accaggtttc tggcctgagc gacaaaaagt   2220

tccagagacc taatgacttc tcaccccctt tccgctttgg gaccgtgccc aacggcagca   2280

cagagagaaa tattcgcaat aactatgcag aaatgcatgc ctacatggga aagttcaacc   2340

agaggggtgt agatgatgca ttgctctccc tgaaaacagg gaaactggat gccttcatct   2400

atgatgcagc agtgctgaac tatatggcag gcagagatga aggctgcaag ctggtgacca   2460

ttggcagtgg gaaggtcttt gcttccactg gctatggcat tgccatccaa aaagattctg   2520

ggtggaagcg ccaggtggac cttgctatcc tgcagctctt tggagatggg gagatggaag   2580

aactggaagc tctctggctc actggcattt gtcacaatga gaagaatgag gtcatgagca   2640

gccagctgga cattgacaac atggcagggg tcttctacat gttgggggcg gccatggctc   2700

tcagcctcat caccttcatc tgcgaacacc ttttctattg gcagttccga cattgcttta   2760

tgggtgtctg ttctggcaag cctggcatgg tcttctccat cagcagaggt atctacagct   2820

gcatccatgg ggtggcgatc gaggagcgcc agtctgtaat gaactccccc accgcaacca   2880

tgaacaacac acactccaac atcctgcgcc tgctgcgcac ggccaagaac atggctaacc   2940

tgtctggtgt gaatggctca ccgcagagcg ccctggactt catccgacgg gagtcatccg   3000

tctatgacat ctcagagcac cgccgcagct tcacgcattc tgactgcaaa tcctacaaca   3060

acccgccctg tgaggagaac ctcttcagtg actacatcag tgaggtagag agaacgttcg   3120

ggaacctgca gctgaaggac agcaacgtgt accaagatca ctaccaccat caccaccggc   3180

cccatagtat tggcagtgcc agctccatcg atgggctcta cgactgtgac aacccaccct   3240

tcaccaccca gtccaggtcc atcagcaaga agcccctgga catcggcctc ccctcctcca   3300

agcacagcca gctcagtgac ctgtacggca aattctcctt caagagcgac cgctacagtg   3360

gccacgacga cttgatccgc tccgatgtct ctgacatctc aacccacacc gtcacctatg   3420

ggaacatcga gggcaatgcc gccaagaggc gtaagcagca atataaggac agcctgaaga   3480

agcggcctgc ctcggccaag tcccgcaggg agtttgacga gatcgagctg gcctaccgtc   3540

gccgaccgcc ccgctcccct gaccacaagc gctacttcag ggacaaggaa gggctacggg   3600

acttctacct ggaccagttc cgaacaaagg agaactcacc ccactgggag cacgtagacc   3660

tgaccgacat ctacaaggag cggagtgatg actttaagcg cgactccatc agcggaggag   3720

ggccctgtac caacaggtct cacatcaagc acgggacggg cgacaaacac ggcgtggtca   3780

gcggggtacc tgcaccttgg gagaagaacc tgaccaacgt ggagtgggag gaccggtccg   3840

ggggcaactt ctgccgcagc tgtccctcca agctgcacaa ctactccacg acggtgacgg   3900

gtcagaactc gggcaggcag gcgtgcatcc ggtgtgaggc ttgcaagaaa gcaggcaacc   3960

tgtatgacat cagtgaggac aactccctgc aggaactgga ccagccggct gccccagtgg   4020

cggtgacgtc aaacgcctcc accactaagt accctcagag cccgactaat tccaaggccc   4080

agaagaagaa ccggaacaaa ctgcgccggc agcactccta cgacaccttc gtggacctgc   4140

agaaggaaga agccgccctg gccccgcgca gcgtaagcct gaaagacaag ggccgattca   4200

tggatgggag cccctacgcc cacatgtttg agatgtcagc tggcgagagc acctttgcca   4260

acaacaagtc ctcagtgccc actgccggac atcaccacca caacaacccc ggcggcgggt   4320

acatgctcag caagtcgctc taccctgacc gggtcacgca aaaccctttc atccccactt   4380

ttggggacga ccagtgcttg ctccatggca gcaaatccta cttcttcagg cagcccacgg   4440

tggcgggggc gtcgaaagcc aggccggact tccgggccct tgtcaccaac aagccggtgg   4500

tctcggccct tcatggggcc gtgccagccc gtttccagaa ggacatctgt atagggaacc   4560

agtccaaccc ctgtgtgcct aacaacaaaa accccagggc tttcaatggc tccagcaatg   4620

ggcatgttta tgagaaactt tctagtattg agtctgatgt ctgagtgagg gaacagagag   4680

gttaaggtgg gtacgggagg gtaaggctgt gggtcgcgtg atgcgcatgt cacggagggt   4740

gacgggggtg aacttggttc ccatttgctc ctttcttgtt ttaatttatt tatgggatcc   4800

tggagttctg gttcctactg ggggcaaccc tggtgaccag caccatctct cctccttttc   4860

acagttctct ccttcttccc cccgctgtca gccattcctg ttcccatgag atgatgccat   4920

gggccctctc agcaggggag ggtagagcgg agaaaggaag ggctgcatgc gggcttcctc   4980

ctggtgtgga agagctcctt gatatcctct ttgagtgaag ctgggagaac caaaaagagg   5040

ctatgtgagc acaaaggtag cttttcccaa actgatcttt tcatttaggt gaggaagcaa   5100

aagcatctat gtgagaccat ttagcacact gcttgtgaaa ggaaagaggc tctggctaaa   5160

ttcatgctgc ttagatgaca tctgtctagg aatcatgtgc caagcagagg ttgggaggcc   5220

atttgtgttt atatataagc ccaaaaatgc ttgcttcaac cccatgagac tcgatagtgg   5280

tggtgaacag aacccaaggt cattggtggc agagtggatt cttgaacaaa ctggaaagta   5340

cgttatgata gtgtcccccg gtgccttggg gacaagagca ggtggattgt gcgtgcatgt   5400

gtgttcatgc acacttgcac ccatgtgtag tcaggtgcct caagagaagg caaccttgac   5460

tcttttattg tttctttcaa tatccccaag cagtgtgatt gtttggctta tatacagaca   5520

gagatggcca tgtattacct gaattttggc tgtgtctccc ttcatccttc tggaataagg   5580

agaatgaaaa ttcttgataa agaagattct gtggtctaaa caaaaaaagg cggtgagcaa   5640

tcctgcaaga gcaaggtaca taaacaagtc ctcagtggtt ggcaactgtt tcaacttgtt   5700

tgaaccaaga accttccagg aaggctaaag ggaaaccgaa tttcacagcc atgattcttt   5760

tgcccacact tgggacgaaa agattctaca aagctctttt gagcatttag actctcgact   5820

ggccaaggtt tggggaagaa cgaacggacc tttgaagaag taaggagtcg tgtatggtag   5880

ggtaagtgag agagggggat gtttcctatg ctttgatccc ttctcactta acctgaagct   5940

agacgagcag gcttcttccc cccaaaactg attacaactg ctacagagca gacagttaag   6000

agaaatgagc ttgacattta agagaaatga gctgcactcc atgagtgcag ctctggaggt   6060

acgaaaagag gggaagagac ttggaaatgg gagacggggg cagagaggga ccctccacca   6120

cctctttggg cctggctggg tgggaatgtg acttgagccc agagtgaaca ctcttggtag   6180

aagcccttct accttcctgc aacacctgtt ccctctcaga ttgtaccatt gagccggaac   6240


<210>  2933
<211>  1484
<212>  PRT
<213>  Homosapiens

<400>  2933

Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      


Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          


Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              


Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  


Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  


Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      


Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         


Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             


Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 


Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 


Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     


Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         


Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             


Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 


Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 


Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     


Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         


Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             


Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 


Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 


Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     


Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         


Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             


Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 


Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 


Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu 
        435                 440                 445             


Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
    450                 455                 460                 


Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
465                 470                 475                 480 


Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                485                 490                 495     


Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
            500                 505                 510         


Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
        515                 520                 525             


Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr 
    530                 535                 540                 


Val Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Asp Val Trp Val 
545                 550                 555                 560 


Met Met Phe Val Met Leu Leu Ile Val Ser Ala Val Ala Val Phe Val 
                565                 570                 575     


Phe Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Cys Leu Ala Asp Gly 
            580                 585                 590         


Arg Glu Pro Gly Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu 
        595                 600                 605             


Leu Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys 
    610                 615                 620                 


Gly Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val 
625                 630                 635                 640 


Ile Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln 
                645                 650                 655     


Glu Glu Tyr Val Asp Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln 
            660                 665                 670         


Arg Pro Asn Asp Phe Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn 
        675                 680                 685             


Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala 
    690                 695                 700                 


Tyr Met Gly Lys Phe Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser 
705                 710                 715                 720 


Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu 
                725                 730                 735     


Asn Tyr Met Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly 
            740                 745                 750         


Ser Gly Lys Val Phe Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys 
        755                 760                 765             


Asp Ser Gly Trp Lys Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe 
    770                 775                 780                 


Gly Asp Gly Glu Met Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile 
785                 790                 795                 800 


Cys His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp 
                805                 810                 815     


Asn Met Ala Gly Val Phe Tyr Met Leu Gly Ala Ala Met Ala Leu Ser 
            820                 825                 830         


Leu Ile Thr Phe Ile Cys Glu His Leu Phe Tyr Trp Gln Phe Arg His 
        835                 840                 845             


Cys Phe Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile 
    850                 855                 860                 


Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile Glu Glu Arg 
865                 870                 875                 880 


Gln Ser Val Met Asn Ser Pro Thr Ala Thr Met Asn Asn Thr His Ser 
                885                 890                 895     


Asn Ile Leu Arg Leu Leu Arg Thr Ala Lys Asn Met Ala Asn Leu Ser 
            900                 905                 910         


Gly Val Asn Gly Ser Pro Gln Ser Ala Leu Asp Phe Ile Arg Arg Glu 
        915                 920                 925             


Ser Ser Val Tyr Asp Ile Ser Glu His Arg Arg Ser Phe Thr His Ser 
    930                 935                 940                 


Asp Cys Lys Ser Tyr Asn Asn Pro Pro Cys Glu Glu Asn Leu Phe Ser 
945                 950                 955                 960 


Asp Tyr Ile Ser Glu Val Glu Arg Thr Phe Gly Asn Leu Gln Leu Lys 
                965                 970                 975     


Asp Ser Asn Val Tyr Gln Asp His Tyr His His His His Arg Pro His 
            980                 985                 990         


Ser Ile Gly Ser Ala Ser Ser Ile  Asp Gly Leu Tyr Asp  Cys Asp Asn 
        995                 1000                 1005             


Pro Pro  Phe Thr Thr Gln Ser  Arg Ser Ile Ser Lys  Lys Pro Leu 
    1010                 1015                 1020             


Asp Ile  Gly Leu Pro Ser Ser  Lys His Ser Gln Leu  Ser Asp Leu 
    1025                 1030                 1035             


Tyr Gly  Lys Phe Ser Phe Lys  Ser Asp Arg Tyr Ser  Gly His Asp 
    1040                 1045                 1050             


Asp Leu  Ile Arg Ser Asp Val  Ser Asp Ile Ser Thr  His Thr Val 
    1055                 1060                 1065             


Thr Tyr  Gly Asn Ile Glu Gly  Asn Ala Ala Lys Arg  Arg Lys Gln 
    1070                 1075                 1080             


Gln Tyr  Lys Asp Ser Leu Lys  Lys Arg Pro Ala Ser  Ala Lys Ser 
    1085                 1090                 1095             


Arg Arg  Glu Phe Asp Glu Ile  Glu Leu Ala Tyr Arg  Arg Arg Pro 
    1100                 1105                 1110             


Pro Arg  Ser Pro Asp His Lys  Arg Tyr Phe Arg Asp  Lys Glu Gly 
    1115                 1120                 1125             


Leu Arg  Asp Phe Tyr Leu Asp  Gln Phe Arg Thr Lys  Glu Asn Ser 
    1130                 1135                 1140             


Pro His  Trp Glu His Val Asp  Leu Thr Asp Ile Tyr  Lys Glu Arg 
    1145                 1150                 1155             


Ser Asp  Asp Phe Lys Arg Asp  Ser Ile Ser Gly Gly  Gly Pro Cys 
    1160                 1165                 1170             


Thr Asn  Arg Ser His Ile Lys  His Gly Thr Gly Asp  Lys His Gly 
    1175                 1180                 1185             


Val Val  Ser Gly Val Pro Ala  Pro Trp Glu Lys Asn  Leu Thr Asn 
    1190                 1195                 1200             


Val Glu  Trp Glu Asp Arg Ser  Gly Gly Asn Phe Cys  Arg Ser Cys 
    1205                 1210                 1215             


Pro Ser  Lys Leu His Asn Tyr  Ser Thr Thr Val Thr  Gly Gln Asn 
    1220                 1225                 1230             


Ser Gly  Arg Gln Ala Cys Ile  Arg Cys Glu Ala Cys  Lys Lys Ala 
    1235                 1240                 1245             


Gly Asn  Leu Tyr Asp Ile Ser  Glu Asp Asn Ser Leu  Gln Glu Leu 
    1250                 1255                 1260             


Asp Gln  Pro Ala Ala Pro Val  Ala Val Thr Ser Asn  Ala Ser Thr 
    1265                 1270                 1275             


Thr Lys  Tyr Pro Gln Ser Pro  Thr Asn Ser Lys Ala  Gln Lys Lys 
    1280                 1285                 1290             


Asn Arg  Asn Lys Leu Arg Arg  Gln His Ser Tyr Asp  Thr Phe Val 
    1295                 1300                 1305             


Asp Leu  Gln Lys Glu Glu Ala  Ala Leu Ala Pro Arg  Ser Val Ser 
    1310                 1315                 1320             


Leu Lys  Asp Lys Gly Arg Phe  Met Asp Gly Ser Pro  Tyr Ala His 
    1325                 1330                 1335             


Met Phe  Glu Met Ser Ala Gly  Glu Ser Thr Phe Ala  Asn Asn Lys 
    1340                 1345                 1350             


Ser Ser  Val Pro Thr Ala Gly  His His His His Asn  Asn Pro Gly 
    1355                 1360                 1365             


Gly Gly  Tyr Met Leu Ser Lys  Ser Leu Tyr Pro Asp  Arg Val Thr 
    1370                 1375                 1380             


Gln Asn  Pro Phe Ile Pro Thr  Phe Gly Asp Asp Gln  Cys Leu Leu 
    1385                 1390                 1395             


His Gly  Ser Lys Ser Tyr Phe  Phe Arg Gln Pro Thr  Val Ala Gly 
    1400                 1405                 1410             


Ala Ser  Lys Ala Arg Pro Asp  Phe Arg Ala Leu Val  Thr Asn Lys 
    1415                 1420                 1425             


Pro Val  Val Ser Ala Leu His  Gly Ala Val Pro Ala  Arg Phe Gln 
    1430                 1435                 1440             


Lys Asp  Ile Cys Ile Gly Asn  Gln Ser Asn Pro Cys  Val Pro Asn 
    1445                 1450                 1455             


Asn Lys  Asn Pro Arg Ala Phe  Asn Gly Ser Ser Asn  Gly His Val 
    1460                 1465                 1470             


Tyr Glu  Lys Leu Ser Ser Ile  Glu Ser Asp Val 
    1475                 1480                 


<210>  2934
<211>  4661
<212>  DNA
<213>  Homosapiens

<400>  2934
tttttgaatc tgcggaggcg gcggcggtgg cagcggcggc gcggcgactg aagcgcgcga     60

aaagctgagg cggcaacgtc ggggacggct gcgcgggacg gctctgtagg aaggaacttg    120

gttccccctc cctcagcttc cgccccaaaa gattcagaat ggacagttta gaagaacctc    180

agaaaaaagt ctttaaggct cgaaaaacga tgagagtgag tgatcgtcag caacttgaag    240

cagtgtacaa ggtcaaagaa gaactgttga aaactgatgt caagctgtta aatggcaacc    300

atgaaaatgg agatttggac ccaacctcac ctttggaaaa catggattac attaaagaca    360

aggaagaggt gaatggcatt gaagagattt gttttgatcc tgaaggaagt aaagcagaat    420

ggaaggaaac accctgtatc ctaagtgtta atgtaaaaaa caagcaggat gatgatttaa    480

attgtgaacc tttgtctccc cataatataa ctccagaacc agtctctaaa ctgcctgctg    540

aaccagtttc tggtgatcca gcccctggtg atctggatgc cggagatcca gcctccggag    600

tactggcctc tggtgattcc acctctggtg atcccacctc tagcgagccc tcctctagtg    660

atgctgcctc tggtgatgca acctctggtg atgccccttc tggtgatgtg tcccctggtg    720

atgccacctc tggtgatgcc actgctgatg atctctcctc tggtgatccc acctctagtg    780

atcccatccc aggtgaaccg gtccctgttg aacccatttc tggtgattgt gccgctgatg    840

atatagcctc tagtgaaata acttctgttg atctggcttc tggagcacca gcttccactg    900

atccagcctc tgatgatctg gcctctggtg atctatcctc tagtgaactg gcctctgatg    960

atctggccac tggtgaactg gcctctgatg agctgacttc tgaatcaacc tttgatcgta   1020

cctttgaacc aaagtctgta ccagtttgtg aaccagttcc tgaaattgac aatatagaac   1080

caagtagcaa taaagatgat gattttcttg aaaaaaatgg agctgatgaa aaattagagc   1140

aaattcagag taaagactca ttggatgaga aaaataaagc tgataataat attgatgcta   1200

atgaagaaac tctagaaaca gatgatacaa ctatttgttc agatcgacct cctgaaaatg   1260

aaaagaaggt agaggaagat attatcacag agcttgctct tggagaagat gctatatcta   1320

gcagtatgga aattgaccaa ggtgaaaaga atgaagatga aacttctgca gatcttgtag   1380

aaacgattaa tgaaaatgtt attgaagata acaaaagtga gaatatctta gaaaatacag   1440

actctatgga gacagatgaa atcattccta ttttggaaaa gcttgcacct tctgaggatg   1500

aacttacttg cttttctaaa acatctctcc ttccaatcga tgagacaaat ccagatttgg   1560

aagagaaaat ggaaagttct tttggttcac catctaaaca agaaagtagt gagagtttgc   1620

caaaagaagc ctttctggtc ctctctgatg aagaggatat ttcgggtgaa aaagatgagt   1680

ctgaagttat atcgcaaaat gaaacgtgct ctccagcaga agtagaaagt aatgaaaagg   1740

acaacaaacc tgaggaagaa gagcaagtaa tacatgaaga tgatgaaaga ccttctgaga   1800

aaaatgaatt ttctagacga aaacgttcta aatcagaaga catggacaat gtacagtcta   1860

aacgtcgtcg atatatggaa gaagaatatg aggcagaatt tcaagtaaag attacagcca   1920

aaggagacat taaccagaaa cttcaaaagg ttatacagtg gttgctggaa gaaaaattgt   1980

gtgcgctgca gtgtgctgta tttgataaga ctttggcaga attgaaaaca cgagtggaaa   2040

agattgaatg taacaagagg cataaaacag ttctcactga actacaggcc aagatagcca   2100

ggttaaccaa acgctttgaa gcagccaaag aagatcttaa gaaaagacat gaacatccac   2160

ccaacccacc agtatcacca ggaaaaactg taaatgatgt caacagcaat aataacatgt   2220

cttacagaaa tgcaggcaca gtgagacaga tgctggagtc caaaagaaat gtaagcgaga   2280

gtgcaccacc atcctttcaa actcctgtga atacagtatc ttcaaccaat cttgtcactc   2340

ctccagcagt tgtcagtagt caacctaaat tgcagactcc agtgacttcg ggttccctca   2400

cagcaacgtc agttcttcct gcacccaata cagctactgt agttgctact actcaggtgc   2460

ctagtggaaa tccccagcct acaatctctt tacagccttt gccagtgatt ttgcatgtac   2520

ctgttgcagt atcctcccag cctcagcttc tacagagcca tccagggact ttggtgacta   2580

atcaaccatc tggcaatgtt gaattcattt ctgtgcaaag cccacctaca gtgagtggtc   2640

ttaccaaaaa tccagtatcc ttgccatcct tgccaaatcc cactaaacca aacaacgttc   2700

cttctgtgcc cagtcctagt attcaaagga accctactgc cagtgctgca ccattgggaa   2760

caacacttgc tgtgcaggct gttccaacag cacactctat tgtacaagcc acaaggactt   2820

ctttacccac agtgggccca tcaggactct atagtccatc aactaatcga ggtcctatac   2880

agatgaaaat tccaatttct gcatttagta cttcgtctgc tgcagaacag aacagcaata   2940

ccaccccaag aattgaaaac cagacaaaca aaacaataga tgcttctgtc agtaagaaag   3000

cagctgatag cacatcacag tgtggaaaag ccactggcag tgattcaagt ggtgtcattg   3060

atctcacaat ggatgatgaa gagagtggag cttcacaaga ccccaaaaaa ctaaatcaca   3120

ctcctgtatc aaccatgagt tcttctcagc ctgtgtcacg accattgcaa cccatacaac   3180

cagcaccgcc tcttcaacca tctggggtgc caacaagtgg accatctcag accaccatac   3240

acttactacc tacagctcca actaccgtga atgtaacaca tcgtccagta actcaggtga   3300

ccacaagact ccctgtacca agagctcctg caaaccacca ggtggtttat acaactcttc   3360

ctgcaccacc agctcaggct cccttgcgag gaactgttat gcaggctcct gctgttcggc   3420

aggtcaatcc ccaaaatagt gttacagttc gagtgcctca aacaaccaca tatgttgtaa   3480

acaatggact aaccctggga tcaacaggac ctcagctcac agtgcatcac cgaccaccac   3540

aagtgcatac tgagccccca cgccccgtgc acccagcacc cttaccagaa gctccacaac   3600

cacagcgtct gcccccagaa gctgccagca catctctgcc tcagaagcca cacttgaagt   3660

tagcacgcgt tcagagtcaa aatggcatag tactgtcatg gagtgtcctg gaggtggatc   3720

gaagctgtgc cactgttgat agctaccatc tctatgctta ccatgaggaa cccagtgcca   3780

ctgtgccctc acaatggaaa aagattgggg aagtcaaggc acttcccttg cccatggcat   3840

gtactctcac ccagtttgta tctggtagca aatactactt tgcagtacga gccaaggata   3900

tttatggacg ttttgggcct ttctgtgatc ctcagtcaac agatgtgatc tcttctaccc   3960

agagcagtta aaccttggag cctttatatt ttcctctttt aaaatttcca ccttttggtc   4020

ttgtttttaa tcttgtgcat gataccccat gtaaaatcca ccttgtgcaa gatttcttgg   4080

acagatgtgt gtatacacta catttgttta taaccagaag caaaataaac tcagcccaca   4140

aagctagaat cttttcctgg acagtttagg ctttggggtt tggaaatgta aatgtgtacc   4200

ttgctttagt tttgaggctg gggaatatgt gtgggtgttt atgtgtgttt ttccttatgt   4260

aggtgttatt gcattggagt ctcccatttt cattctcaaa tttacctctt aaagtacgaa   4320

gtaagtagat caaaggattt gagatgtgta actggcatga ttctgctttt gaaggatcta   4380

tagtatcatt ttagttaagt gggtcaaaca gaatcaaaac aaaacccaaa gaaataaata   4440

aaaaacaaaa tggctaaata gtttaaaata ggttaattcg aacacaggaa aggatctatt   4500

tgttgtttct tttgtctggt ctcctgagtt gttaattagg tgaaaaaaga tctgcaatgg   4560

ccccctccct ttcctaatct ggcttttaca tttattttgt gccttaaaga ttaactacaa   4620

agataaacat ggccaaaaat aaataaataa atatggccat a                       4661


<210>  2935
<211>  1270
<212>  PRT
<213>  Homosapiens

<400>  2935

Met Asp Ser Leu Glu Glu Pro Gln Lys Lys Val Phe Lys Ala Arg Lys 
1               5                   10                  15      


Thr Met Arg Val Ser Asp Arg Gln Gln Leu Glu Ala Val Tyr Lys Val 
            20                  25                  30          


Lys Glu Glu Leu Leu Lys Thr Asp Val Lys Leu Leu Asn Gly Asn His 
        35                  40                  45              


Glu Asn Gly Asp Leu Asp Pro Thr Ser Pro Leu Glu Asn Met Asp Tyr 
    50                  55                  60                  


Ile Lys Asp Lys Glu Glu Val Asn Gly Ile Glu Glu Ile Cys Phe Asp 
65                  70                  75                  80  


Pro Glu Gly Ser Lys Ala Glu Trp Lys Glu Thr Pro Cys Ile Leu Ser 
                85                  90                  95      


Val Asn Val Lys Asn Lys Gln Asp Asp Asp Leu Asn Cys Glu Pro Leu 
            100                 105                 110         


Ser Pro His Asn Ile Thr Pro Glu Pro Val Ser Lys Leu Pro Ala Glu 
        115                 120                 125             


Pro Val Ser Gly Asp Pro Ala Pro Gly Asp Leu Asp Ala Gly Asp Pro 
    130                 135                 140                 


Ala Ser Gly Val Leu Ala Ser Gly Asp Ser Thr Ser Gly Asp Pro Thr 
145                 150                 155                 160 


Ser Ser Glu Pro Ser Ser Ser Asp Ala Ala Ser Gly Asp Ala Thr Ser 
                165                 170                 175     


Gly Asp Ala Pro Ser Gly Asp Val Ser Pro Gly Asp Ala Thr Ser Gly 
            180                 185                 190         


Asp Ala Thr Ala Asp Asp Leu Ser Ser Gly Asp Pro Thr Ser Ser Asp 
        195                 200                 205             


Pro Ile Pro Gly Glu Pro Val Pro Val Glu Pro Ile Ser Gly Asp Cys 
    210                 215                 220                 


Ala Ala Asp Asp Ile Ala Ser Ser Glu Ile Thr Ser Val Asp Leu Ala 
225                 230                 235                 240 


Ser Gly Ala Pro Ala Ser Thr Asp Pro Ala Ser Asp Asp Leu Ala Ser 
                245                 250                 255     


Gly Asp Leu Ser Ser Ser Glu Leu Ala Ser Asp Asp Leu Ala Thr Gly 
            260                 265                 270         


Glu Leu Ala Ser Asp Glu Leu Thr Ser Glu Ser Thr Phe Asp Arg Thr 
        275                 280                 285             


Phe Glu Pro Lys Ser Val Pro Val Cys Glu Pro Val Pro Glu Ile Asp 
    290                 295                 300                 


Asn Ile Glu Pro Ser Ser Asn Lys Asp Asp Asp Phe Leu Glu Lys Asn 
305                 310                 315                 320 


Gly Ala Asp Glu Lys Leu Glu Gln Ile Gln Ser Lys Asp Ser Leu Asp 
                325                 330                 335     


Glu Lys Asn Lys Ala Asp Asn Asn Ile Asp Ala Asn Glu Glu Thr Leu 
            340                 345                 350         


Glu Thr Asp Asp Thr Thr Ile Cys Ser Asp Arg Pro Pro Glu Asn Glu 
        355                 360                 365             


Lys Lys Val Glu Glu Asp Ile Ile Thr Glu Leu Ala Leu Gly Glu Asp 
    370                 375                 380                 


Ala Ile Ser Ser Ser Met Glu Ile Asp Gln Gly Glu Lys Asn Glu Asp 
385                 390                 395                 400 


Glu Thr Ser Ala Asp Leu Val Glu Thr Ile Asn Glu Asn Val Ile Glu 
                405                 410                 415     


Asp Asn Lys Ser Glu Asn Ile Leu Glu Asn Thr Asp Ser Met Glu Thr 
            420                 425                 430         


Asp Glu Ile Ile Pro Ile Leu Glu Lys Leu Ala Pro Ser Glu Asp Glu 
        435                 440                 445             


Leu Thr Cys Phe Ser Lys Thr Ser Leu Leu Pro Ile Asp Glu Thr Asn 
    450                 455                 460                 


Pro Asp Leu Glu Glu Lys Met Glu Ser Ser Phe Gly Ser Pro Ser Lys 
465                 470                 475                 480 


Gln Glu Ser Ser Glu Ser Leu Pro Lys Glu Ala Phe Leu Val Leu Ser 
                485                 490                 495     


Asp Glu Glu Asp Ile Ser Gly Glu Lys Asp Glu Ser Glu Val Ile Ser 
            500                 505                 510         


Gln Asn Glu Thr Cys Ser Pro Ala Glu Val Glu Ser Asn Glu Lys Asp 
        515                 520                 525             


Asn Lys Pro Glu Glu Glu Glu Gln Val Ile His Glu Asp Asp Glu Arg 
    530                 535                 540                 


Pro Ser Glu Lys Asn Glu Phe Ser Arg Arg Lys Arg Ser Lys Ser Glu 
545                 550                 555                 560 


Asp Met Asp Asn Val Gln Ser Lys Arg Arg Arg Tyr Met Glu Glu Glu 
                565                 570                 575     


Tyr Glu Ala Glu Phe Gln Val Lys Ile Thr Ala Lys Gly Asp Ile Asn 
            580                 585                 590         


Gln Lys Leu Gln Lys Val Ile Gln Trp Leu Leu Glu Glu Lys Leu Cys 
        595                 600                 605             


Ala Leu Gln Cys Ala Val Phe Asp Lys Thr Leu Ala Glu Leu Lys Thr 
    610                 615                 620                 


Arg Val Glu Lys Ile Glu Cys Asn Lys Arg His Lys Thr Val Leu Thr 
625                 630                 635                 640 


Glu Leu Gln Ala Lys Ile Ala Arg Leu Thr Lys Arg Phe Glu Ala Ala 
                645                 650                 655     


Lys Glu Asp Leu Lys Lys Arg His Glu His Pro Pro Asn Pro Pro Val 
            660                 665                 670         


Ser Pro Gly Lys Thr Val Asn Asp Val Asn Ser Asn Asn Asn Met Ser 
        675                 680                 685             


Tyr Arg Asn Ala Gly Thr Val Arg Gln Met Leu Glu Ser Lys Arg Asn 
    690                 695                 700                 


Val Ser Glu Ser Ala Pro Pro Ser Phe Gln Thr Pro Val Asn Thr Val 
705                 710                 715                 720 


Ser Ser Thr Asn Leu Val Thr Pro Pro Ala Val Val Ser Ser Gln Pro 
                725                 730                 735     


Lys Leu Gln Thr Pro Val Thr Ser Gly Ser Leu Thr Ala Thr Ser Val 
            740                 745                 750         


Leu Pro Ala Pro Asn Thr Ala Thr Val Val Ala Thr Thr Gln Val Pro 
        755                 760                 765             


Ser Gly Asn Pro Gln Pro Thr Ile Ser Leu Gln Pro Leu Pro Val Ile 
    770                 775                 780                 


Leu His Val Pro Val Ala Val Ser Ser Gln Pro Gln Leu Leu Gln Ser 
785                 790                 795                 800 


His Pro Gly Thr Leu Val Thr Asn Gln Pro Ser Gly Asn Val Glu Phe 
                805                 810                 815     


Ile Ser Val Gln Ser Pro Pro Thr Val Ser Gly Leu Thr Lys Asn Pro 
            820                 825                 830         


Val Ser Leu Pro Ser Leu Pro Asn Pro Thr Lys Pro Asn Asn Val Pro 
        835                 840                 845             


Ser Val Pro Ser Pro Ser Ile Gln Arg Asn Pro Thr Ala Ser Ala Ala 
    850                 855                 860                 


Pro Leu Gly Thr Thr Leu Ala Val Gln Ala Val Pro Thr Ala His Ser 
865                 870                 875                 880 


Ile Val Gln Ala Thr Arg Thr Ser Leu Pro Thr Val Gly Pro Ser Gly 
                885                 890                 895     


Leu Tyr Ser Pro Ser Thr Asn Arg Gly Pro Ile Gln Met Lys Ile Pro 
            900                 905                 910         


Ile Ser Ala Phe Ser Thr Ser Ser Ala Ala Glu Gln Asn Ser Asn Thr 
        915                 920                 925             


Thr Pro Arg Ile Glu Asn Gln Thr Asn Lys Thr Ile Asp Ala Ser Val 
    930                 935                 940                 


Ser Lys Lys Ala Ala Asp Ser Thr Ser Gln Cys Gly Lys Ala Thr Gly 
945                 950                 955                 960 


Ser Asp Ser Ser Gly Val Ile Asp Leu Thr Met Asp Asp Glu Glu Ser 
                965                 970                 975     


Gly Ala Ser Gln Asp Pro Lys Lys Leu Asn His Thr Pro Val Ser Thr 
            980                 985                 990         


Met Ser Ser Ser Gln Pro Val Ser  Arg Pro Leu Gln Pro  Ile Gln Pro 
        995                 1000                 1005             


Ala Pro  Pro Leu Gln Pro Ser  Gly Val Pro Thr Ser  Gly Pro Ser 
    1010                 1015                 1020             


Gln Thr  Thr Ile His Leu Leu  Pro Thr Ala Pro Thr  Thr Val Asn 
    1025                 1030                 1035             


Val Thr  His Arg Pro Val Thr  Gln Val Thr Thr Arg  Leu Pro Val 
    1040                 1045                 1050             


Pro Arg  Ala Pro Ala Asn His  Gln Val Val Tyr Thr  Thr Leu Pro 
    1055                 1060                 1065             


Ala Pro  Pro Ala Gln Ala Pro  Leu Arg Gly Thr Val  Met Gln Ala 
    1070                 1075                 1080             


Pro Ala  Val Arg Gln Val Asn  Pro Gln Asn Ser Val  Thr Val Arg 
    1085                 1090                 1095             


Val Pro  Gln Thr Thr Thr Tyr  Val Val Asn Asn Gly  Leu Thr Leu 
    1100                 1105                 1110             


Gly Ser  Thr Gly Pro Gln Leu  Thr Val His His Arg  Pro Pro Gln 
    1115                 1120                 1125             


Val His  Thr Glu Pro Pro Arg  Pro Val His Pro Ala  Pro Leu Pro 
    1130                 1135                 1140             


Glu Ala  Pro Gln Pro Gln Arg  Leu Pro Pro Glu Ala  Ala Ser Thr 
    1145                 1150                 1155             


Ser Leu  Pro Gln Lys Pro His  Leu Lys Leu Ala Arg  Val Gln Ser 
    1160                 1165                 1170             


Gln Asn  Gly Ile Val Leu Ser  Trp Ser Val Leu Glu  Val Asp Arg 
    1175                 1180                 1185             


Ser Cys  Ala Thr Val Asp Ser  Tyr His Leu Tyr Ala  Tyr His Glu 
    1190                 1195                 1200             


Glu Pro  Ser Ala Thr Val Pro  Ser Gln Trp Lys Lys  Ile Gly Glu 
    1205                 1210                 1215             


Val Lys  Ala Leu Pro Leu Pro  Met Ala Cys Thr Leu  Thr Gln Phe 
    1220                 1225                 1230             


Val Ser  Gly Ser Lys Tyr Tyr  Phe Ala Val Arg Ala  Lys Asp Ile 
    1235                 1240                 1245             


Tyr Gly  Arg Phe Gly Pro Phe  Cys Asp Pro Gln Ser  Thr Asp Val 
    1250                 1255                 1260             


Ile Ser  Ser Thr Gln Ser Ser  
    1265                 1270 


<210>  2936
<211>  3745
<212>  DNA
<213>  Homosapiens

<400>  2936
cgcaaagcaa gtgggcacaa ggagtatggt tctaacgtga ttggggtcat gaagacgttg     60

ctgttggact tggctttgtg gtcactgctc ttccagcccg ggtggctgtc ctttagttcc    120

caggtgagtc agaactgcca caatggcagc tatgaaatca gcgtcctgat gatgggcaac    180

tcagcctttg cagagcccct gaaaaacttg gaagatgcgg tgaatgaggg gctggaaata    240

gtgagaggac gtctgcaaaa tgctggccta aatgtgactg tgaacgctac tttcatgtat    300

tcggatggtc tgattcataa ctcaggcgac tgccggagta gcacctgtga aggcctcgac    360

ctactcagga aaatttcaaa tgcacaacgg atgggctgtg tcctcatagg gccctcatgt    420

acatactcca ccttccagat gtaccttgac acagaattga gctaccccat gatctcagct    480

ggaagttttg gattgtcatg tgactataaa gaaaccttaa ccaggctgat gtctccagct    540

agaaagttga tgtacttctt ggttaacttt tggaaaacca acgatctgcc cttcaaaact    600

tattcctgga gcacttcgta tgtttacaag aatggtacag aaactgagga ctgtttctgg    660

taccttaatg ctctggaggc tagcgtttcc tatttctccc acgaactcgg ctttaaggtg    720

gtgttaagac aagataagga gtttcaggat atcttaatgg accacaacag gaaaagcaat    780

gtgattatta tgtgtggtgg tccagagttc ctctacaagc tgaagggtga ccgagcagtg    840

gctgaagaca ttgtcattat tctagtggat cttttcaatg accagtactt ggaggacaat    900

gtcacagccc ctgactatat gaaaaatgtc cttgttctga cgctgtctcc tgggaattcc    960

cttctaaata gctctttctc caggaatcta tcaccaacaa aacgagactt tgctcttgcc   1020

tatttgaatg gaatcctgct ctttggacat atgctgaaga tatttcttga aaatggagaa   1080

aatattacca cccccaaatt tgctcatgct ttcaggaatc tcacttttga agggtatgac   1140

ggtccagtga ccttggatga ctggggggat gttgacagta ccatggtgct tctgtatacc   1200

tctgtggaca ccaagaaata caaggttctt ttgacctatg atacccacgt aaataagacc   1260

tatcctgtgg atatgagccc cacattcact tggaagaact ctaaacttcc taatgatatt   1320

acaggccggg gccctcagat cctgatgatt gcagtcttca ccctcactgg agctgtggtg   1380

ctgctcctgc tcgtcgctct cctgatgctc agaaaatata gaaaagatta tgaacttcgt   1440

cagaaaaaat ggtcccacat tcctcctgaa aatatctttc ctctggagac caatgagacc   1500

aatcatgtta gcctcaagat cgatgatgac aaaagacgag atacaatcca gagactacga   1560

cagtgcaaat acgacaaaaa gcgagtgatt ctcaaagatc tcaagcacaa tgatggtaat   1620

ttcactgaaa aacagaagat agaattgaac aagttgcttc agattgacta ttacaacctg   1680

accaagttct acggcacagt gaaacttgat accatgatct tcggggtgat agaatactgt   1740

gagagaggat ccctccggga agttttaaat gacacaattt cctaccctga tggcacattc   1800

atggattggg agtttaagat ctctgtcttg tatgacattg ctaagggaat gtcatatctg   1860

cactccagta agacagaagt ccatggtcgt ctgaaatcta ccaactgcgt agtggacagt   1920

agaatggtgg tgaagatcac tgattttggc tgcaattcca ttttacctcc aaaaaaggac   1980

ctgtggacag ctccagagca cctccgccaa gccaacatct ctcagaaagg agatgtgtac   2040

agctatggga tcatcgcaca ggagatcatt ctgcggaaag aaaccttcta cactttgagc   2100

tgtcgggacc ggaatgagaa gattttcaga gtggaaaatt ccaatggaat gaaacccttc   2160

cgcccagatt tattcttgga aacagcagag gaaaaagagc tagaagtgta cctacttgta   2220

aaaaactgtt gggaggaaga tccagaaaag agaccagatt tcaaaaaaat tgagactaca   2280

cttgccaaga tatttggact ttttcatgac caaaaaaatg aaagctatat ggataccttg   2340

atccgacgtc tacagctata ttctcgaaac ctggaacatc tggtagagga aaggacacag   2400

ctgtacaagg cagagaggga cagggctgac agacttaact ttatgttgct tccaaggcta   2460

gtggtaaagt ctctgaagga gaaaggcttt gtggagccgg aactatatga ggaagttaca   2520

atctacttca gtgacattgt aggtttcact actatctgca aatacagcac ccccatggaa   2580

gtggtggaca tgcttaatga catctataag agttttgacc acattgttga tcatcatgat   2640

gtctacaagg tggaaaccat cggtgatgcg tacatggtgg ctagtggttt gcctaagaga   2700

aatggcaatc ggcatgcaat agacattgcc aagatggcct tggaaatcct cagcttcatg   2760

gggacctttg agctggagca tcttcctggc ctcccaatat ggattcgcat tggagttcac   2820

tctggtccct gtgctgctgg agttgtggga atcaagatgc ctcgttattg tctatttgga   2880

gatacggtca acacagcctc taggatggaa tccactggcc tccctttgag aattcacgtg   2940

agtggctcca ccatagccat cctgaagaga actgagtgcc agttccttta tgaagtgaga   3000

ggagaaacat acttaaaggg aagaggaaat gagactacct actggctgac tgggatgaag   3060

gaccagaaat tcaacctgcc aacccctcct actgtggaga atcaacagcg tttgcaagca   3120

gaattttcag acatgattgc caactcttta cagaaaagac aggcagcagg gataagaagc   3180

caaaaaccca gacgggtagc cagctataaa aaaggcactc tggaatactt gcagctgaat   3240

accacagaca aggagagcac ctatttttaa acctaaatga ggtataagga ctcacacaaa   3300

ttaaaataca gctgcactga ggcagcgacc tcaagtgtcc tgaaagctta cattttcctg   3360

agacctcaat gaagcagaaa tgtacttagg cttggctgcc ctgtctggaa catggacttt   3420

cttgcatgaa tcagatgtgt gttctcagtg aaataactac cttccactct ggaaccttat   3480

tccagcagtt gttccaggga gcttctacct ggaaaagaaa agaaatgaat agactatcta   3540

gaacttgaga agattttatt cttatttcat ttattttttg tttgtttatt tttatcgttt   3600

ttgtttactg gctttccttc tgtattcata agatttttta aattgtcata attatatttt   3660

aaatacccat cttcattaaa gtatatttaa ctcataattt ttgcagaaaa tatgctatat   3720

attaggcaag aataaaagct aaagg                                         3745


<210>  2937
<211>  1073
<212>  PRT
<213>  Homosapiens

<400>  2937

Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln 
1               5                   10                  15      


Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn 
            20                  25                  30          


Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala 
        35                  40                  45              


Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile 
    50                  55                  60                  


Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala 
65                  70                  75                  80  


Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg 
                85                  90                  95      


Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala 
            100                 105                 110         


Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr 
        115                 120                 125             


Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala 
    130                 135                 140                 


Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu 
145                 150                 155                 160 


Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys 
                165                 170                 175     


Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val 
            180                 185                 190         


Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala 
        195                 200                 205             


Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val 
    210                 215                 220                 


Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn 
225                 230                 235                 240 


Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr 
                245                 250                 255     


Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu 
            260                 265                 270         


Val Asp Leu Phe Asn Asp Gln Tyr Leu Glu Asp Asn Val Thr Ala Pro 
        275                 280                 285             


Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser 
    290                 295                 300                 


Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp 
305                 310                 315                 320 


Phe Ala Leu Ala Tyr Leu Asn Gly Ile Leu Leu Phe Gly His Met Leu 
                325                 330                 335     


Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala 
            340                 345                 350         


His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr 
        355                 360                 365             


Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr 
    370                 375                 380                 


Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His 
385                 390                 395                 400 


Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys 
                405                 410                 415     


Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro Gln Ile Leu 
            420                 425                 430         


Met Ile Ala Val Phe Thr Leu Thr Gly Ala Val Val Leu Leu Leu Leu 
        435                 440                 445             


Val Ala Leu Leu Met Leu Arg Lys Tyr Arg Lys Asp Tyr Glu Leu Arg 
    450                 455                 460                 


Gln Lys Lys Trp Ser His Ile Pro Pro Glu Asn Ile Phe Pro Leu Glu 
465                 470                 475                 480 


Thr Asn Glu Thr Asn His Val Ser Leu Lys Ile Asp Asp Asp Lys Arg 
                485                 490                 495     


Arg Asp Thr Ile Gln Arg Leu Arg Gln Cys Lys Tyr Asp Lys Lys Arg 
            500                 505                 510         


Val Ile Leu Lys Asp Leu Lys His Asn Asp Gly Asn Phe Thr Glu Lys 
        515                 520                 525             


Gln Lys Ile Glu Leu Asn Lys Leu Leu Gln Ile Asp Tyr Tyr Asn Leu 
    530                 535                 540                 


Thr Lys Phe Tyr Gly Thr Val Lys Leu Asp Thr Met Ile Phe Gly Val 
545                 550                 555                 560 


Ile Glu Tyr Cys Glu Arg Gly Ser Leu Arg Glu Val Leu Asn Asp Thr 
                565                 570                 575     


Ile Ser Tyr Pro Asp Gly Thr Phe Met Asp Trp Glu Phe Lys Ile Ser 
            580                 585                 590         


Val Leu Tyr Asp Ile Ala Lys Gly Met Ser Tyr Leu His Ser Ser Lys 
        595                 600                 605             


Thr Glu Val His Gly Arg Leu Lys Ser Thr Asn Cys Val Val Asp Ser 
    610                 615                 620                 


Arg Met Val Val Lys Ile Thr Asp Phe Gly Cys Asn Ser Ile Leu Pro 
625                 630                 635                 640 


Pro Lys Lys Asp Leu Trp Thr Ala Pro Glu His Leu Arg Gln Ala Asn 
                645                 650                 655     


Ile Ser Gln Lys Gly Asp Val Tyr Ser Tyr Gly Ile Ile Ala Gln Glu 
            660                 665                 670         


Ile Ile Leu Arg Lys Glu Thr Phe Tyr Thr Leu Ser Cys Arg Asp Arg 
        675                 680                 685             


Asn Glu Lys Ile Phe Arg Val Glu Asn Ser Asn Gly Met Lys Pro Phe 
    690                 695                 700                 


Arg Pro Asp Leu Phe Leu Glu Thr Ala Glu Glu Lys Glu Leu Glu Val 
705                 710                 715                 720 


Tyr Leu Leu Val Lys Asn Cys Trp Glu Glu Asp Pro Glu Lys Arg Pro 
                725                 730                 735     


Asp Phe Lys Lys Ile Glu Thr Thr Leu Ala Lys Ile Phe Gly Leu Phe 
            740                 745                 750         


His Asp Gln Lys Asn Glu Ser Tyr Met Asp Thr Leu Ile Arg Arg Leu 
        755                 760                 765             


Gln Leu Tyr Ser Arg Asn Leu Glu His Leu Val Glu Glu Arg Thr Gln 
    770                 775                 780                 


Leu Tyr Lys Ala Glu Arg Asp Arg Ala Asp Arg Leu Asn Phe Met Leu 
785                 790                 795                 800 


Leu Pro Arg Leu Val Val Lys Ser Leu Lys Glu Lys Gly Phe Val Glu 
                805                 810                 815     


Pro Glu Leu Tyr Glu Glu Val Thr Ile Tyr Phe Ser Asp Ile Val Gly 
            820                 825                 830         


Phe Thr Thr Ile Cys Lys Tyr Ser Thr Pro Met Glu Val Val Asp Met 
        835                 840                 845             


Leu Asn Asp Ile Tyr Lys Ser Phe Asp His Ile Val Asp His His Asp 
    850                 855                 860                 


Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Ala Ser Gly 
865                 870                 875                 880 


Leu Pro Lys Arg Asn Gly Asn Arg His Ala Ile Asp Ile Ala Lys Met 
                885                 890                 895     


Ala Leu Glu Ile Leu Ser Phe Met Gly Thr Phe Glu Leu Glu His Leu 
            900                 905                 910         


Pro Gly Leu Pro Ile Trp Ile Arg Ile Gly Val His Ser Gly Pro Cys 
        915                 920                 925             


Ala Ala Gly Val Val Gly Ile Lys Met Pro Arg Tyr Cys Leu Phe Gly 
    930                 935                 940                 


Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser Thr Gly Leu Pro Leu 
945                 950                 955                 960 


Arg Ile His Val Ser Gly Ser Thr Ile Ala Ile Leu Lys Arg Thr Glu 
                965                 970                 975     


Cys Gln Phe Leu Tyr Glu Val Arg Gly Glu Thr Tyr Leu Lys Gly Arg 
            980                 985                 990         


Gly Asn Glu Thr Thr Tyr Trp Leu  Thr Gly Met Lys Asp  Gln Lys Phe 
        995                 1000                 1005             


Asn Leu  Pro Thr Pro Pro Thr  Val Glu Asn Gln Gln  Arg Leu Gln 
    1010                 1015                 1020             


Ala Glu  Phe Ser Asp Met Ile  Ala Asn Ser Leu Gln  Lys Arg Gln 
    1025                 1030                 1035             


Ala Ala  Gly Ile Arg Ser Gln  Lys Pro Arg Arg Val  Ala Ser Tyr 
    1040                 1045                 1050             


Lys Lys  Gly Thr Leu Glu Tyr  Leu Gln Leu Asn Thr  Thr Asp Lys 
    1055                 1060                 1065             


Glu Ser  Thr Tyr Phe 
    1070             


<210>  2938
<211>  2240
<212>  DNA
<213>  Homosapiens

<400>  2938
cgccgggcca ctggcacttg cttctgcggc gagtcccacc cacgaccgca gcccagcaac     60

tcgcaaacgc aacctgaagc ctgggctgcg cagtgtggga gggcttcgcg atcttggggg    120

acccattccg aacttgcaga ggaccgtagc tctcctggcc tggagagtgt gaacaggatt    180

gtggactctt ccaagattca caatgatatg gtgaatccaa agactggaac caaaaagatt    240

tactcagtgc tttagtttta acaacagtaa attgtctacc aacacccatc atggctaaaa    300

gtgcggaggt caaactggca atatttggga gagcaggcgt gggcaagtca gctcttgtag    360

tgagatttct gaccaaacgg ttcatctggg aatatgatcc caccctcgaa tcaacctacc    420

gacaccaagc aaccatcgat gatgaagttg tttccatgga gatactagac actgctggtc    480

aggaagatac cattcagagg gaggggcaca tgcgatgggg ggaaggcttt gtgctggtct    540

acgacattac tgaccgagga agttttgagg aagtgctgcc acttaagaac atcctagatg    600

agatcaaaaa gcccaagaat gtgactctca tcttggttgg aaacaaagct gacttggacc    660

actccaggca ggttagcaca gaagaaggag agaagctggc cacagaattg gcttgtgctt    720

tttacgagtg ctctgcctgc actggagaag ggaacatcac agagatattc tatgaattgt    780

gtcgagaggt gcgtcgccgg aggatggtgc agggcaagac gaggcgacgc agctccacca    840

cgcatgtcaa gcaagccatt aacaagatgc tcaccaaaat cagtagttag gcagcccagc    900

tgaggtggac caactaattg gaaacactct tccccttctg ttcccctttc aaaaataaaa    960

caaaatattg cattctttgt ttggattctg agaaatgtct gggcttccca ttgtttctgg   1020

cctctaatag gttgggaagt tttagcgtgt tttatgcaat ttcagtgcta acaatttctt   1080

cctttcctgc ttgaataaga tacactctaa tggcatttga acatgtaatc accagagatt   1140

ctgaaatgac tggtttatgt taagctattt ttaggcatct tcaccttgct ttaagtaggt   1200

tgaagttttt gcaaaggcat ttaaaaattc aatttcttgt cagatactac aaataatttt   1260

cttaaaagtc taagatagca gaaaatacag taaaaacaca ggagaagaag ctgagctatt   1320

ggaacaggaa atagaaggaa ctctagtttc tgtttgaagt gaggattttc tgaattatct   1380

aatatcatct aggttttctt taaaatttta ttttgttctt cagttcaagc atcttctcac   1440

taatgttttt cactataaca gagaattcat ttcaatttga gttggttctc tcaatgatct   1500

attgatcatt acaccctaac tctccttcct tggctcaaac aatattttcc ctataacaaa   1560

ggcaatagga cacaaaattc acatcctgct gggccttttt tcatcaagtc agggtgatat   1620

aaaaacattg gaagtctttt caccaaaccc tgactttatt gaatgctagt agaagatgta   1680

gaattagaga catctgattt gtttatcacc ttagcagaaa aaccacagtc caaaagacaa   1740

gcaaattaag aatggagctt aaccatgcct ccattgggaa gtctagactt tgagccaggt   1800

acagtaagaa aaattagcct ctgattcatt aagtttgcca catgacttat tttgatattt   1860

tggatacatt aactcactta ggagaattca gaaaagaatg ggtgattaaa gttcattaca   1920

gctgaataaa tgtgtctaaa acagactctt gtattctgaa agtacagtct acaactgata   1980

aaaccttatg attcttttct cccccattat gcccctatat atatcaagat ttgggtactt   2040

tattttagta gaaaatatat atcttttaca tatgtatgta tttataaatg catagatata   2100

tgtataaaaa tttgtaagcg ttagcggcat taattcacca atgcatttgg acaacttgat   2160

gtaactgact ttattttatg tgactataat aaaaagcata attttctcat tctgtcaaaa   2220

aaaaaaaaaa aaaaaaaaaa                                               2240


<210>  2939
<211>  199
<212>  PRT
<213>  Homosapiens

<400>  2939

Met Ala Lys Ser Ala Glu Val Lys Leu Ala Ile Phe Gly Arg Ala Gly 
1               5                   10                  15      


Val Gly Lys Ser Ala Leu Val Val Arg Phe Leu Thr Lys Arg Phe Ile 
            20                  25                  30          


Trp Glu Tyr Asp Pro Thr Leu Glu Ser Thr Tyr Arg His Gln Ala Thr 
        35                  40                  45              


Ile Asp Asp Glu Val Val Ser Met Glu Ile Leu Asp Thr Ala Gly Gln 
    50                  55                  60                  


Glu Asp Thr Ile Gln Arg Glu Gly His Met Arg Trp Gly Glu Gly Phe 
65                  70                  75                  80  


Val Leu Val Tyr Asp Ile Thr Asp Arg Gly Ser Phe Glu Glu Val Leu 
                85                  90                  95      


Pro Leu Lys Asn Ile Leu Asp Glu Ile Lys Lys Pro Lys Asn Val Thr 
            100                 105                 110         


Leu Ile Leu Val Gly Asn Lys Ala Asp Leu Asp His Ser Arg Gln Val 
        115                 120                 125             


Ser Thr Glu Glu Gly Glu Lys Leu Ala Thr Glu Leu Ala Cys Ala Phe 
    130                 135                 140                 


Tyr Glu Cys Ser Ala Cys Thr Gly Glu Gly Asn Ile Thr Glu Ile Phe 
145                 150                 155                 160 


Tyr Glu Leu Cys Arg Glu Val Arg Arg Arg Arg Met Val Gln Gly Lys 
                165                 170                 175     


Thr Arg Arg Arg Ser Ser Thr Thr His Val Lys Gln Ala Ile Asn Lys 
            180                 185                 190         


Met Leu Thr Lys Ile Ser Ser 
        195                 


<210>  2940
<211>  5069
<212>  DNA
<213>  Homosapiens

<400>  2940
gggcgcagag gaggaaaggg agcaggcgca gggggactgg aaaggcagca tgcgctcgcc     60

aggagcaacc tcggcgccca gggtctgagg ctgcagcccc agttcgccat tgtgagccgc    120

cgccggggga gtccgctagc gcagccgtgc ccccgagtcc ccgtccgcgc agcgatgggg    180

cacctgccca cggggataca cggcgcccgc cgcctcctgc ctctgctctg gctctttgtg    240

ctgttcaaga atgctacagc tttccatgta actgtccaag atgataataa catcgttgtc    300

tcattagaag cttcagacgt catcagtcca gcatctgtgt atgttgtgaa gataactggt    360

gaatccaaaa attatttctt cgaatttgag gaattcaaca gcactttgcc tcctcctgtt    420

attttcaagg ccagttatca tggcctttat tatataatca ctctggtagt ggtaaatgga    480

aatgtggtga ccaagccatc cagatcaatc actgtgttaa caaaacctct acctgtaacc    540

agtgtttcca tatatgacta taaaccttct cctgaaacag gagtcctgtt tgaaatacat    600

tatccagaaa aatataacgt tttcacaaga gtgaacatta gctactggga aggtaaagac    660

ttccggacaa tgctatataa agatttcttt aagggaaaaa cagtatttaa tcactggctg    720

ccaggaatgt gttatagtaa tatcaccttt cagctggtat ctgaggcaac ttttaataaa    780

agtacccttg ttgagtacag tggtgtcagt cacgaaccca aacagcacag aactgcccct    840

tatccacctc aaaatatttc cgttcgtatc gtaaacttga acaaaaacaa ctgggaagaa    900

cagagtggca atttcccaga agaatccttc atgagatcac aagatacaat aggaaaagaa    960

aaactcttcc attttacaga agaaacccct gaaattccct cgggcaacat ttcttccggt   1020

tggcctgatt ttaatagcag tgactatgaa actacgtctc agccatattg gtgggacagt   1080

gcatctgcag ctcctgaaag tgaagatgaa tttgtcagcg tacttcccat ggaatacgaa   1140

aataacagta cactcagtga gacagagaag tcaacatcag gctctttctc ctttttccct   1200

gtgcaaatga tattgacctg gttaccaccc aaaccaccca ctgcttttga tgggttccat   1260

atccatattg aacgagaaga gaactttact gaatatttga tggtggatga agaagcacat   1320

gaatttgttg cagaactgaa ggaacctggg aaatataagt tatctgtgac aacctttagt   1380

tcctcaggat cttgtgaaac tcgaaaaagt cagtcagcaa aatcactcag cttttatatc   1440

agtccttcag gagagtggat tgaagaactg accgagaagc cgcagcacgt gagtgtccac   1500

gttttaagct caaccactgc cttgatgtcc tggacatctt cccaagagaa ctacaacagc   1560

accattgtgt ctgtggtgtc gctgacctgc cagaaacaaa aggagagcca gaggcttgaa   1620

aagcagtact gcactcaggt gaactcaagc aaacctatta ttgaaaatct ggttcctggt   1680

gcccagtacc aggttgtaat atacctaagg aaaggccctt tgattggacc accttcagat   1740

cctgtgacat ttgctattgt tcccacagga ataaaggatt taatgctcta tcctttgggt   1800

cctacggccg tggttctgag ctggaccaga ccttatttag gcgtgttcag aaaatacgtg   1860

gttgaaatgt tttatttcaa ccctgctaca atgacatcag agtggaccac ctactatgaa   1920

atagcagcaa ctgtttcctt aactgcatcc gtgagaatag ctaatctgct gccagcatgg   1980

tactacaact tccgggttac catggtgacg tggggagatc cagaattgag ctgctgtgac   2040

agctctacca tcagcttcat aacagcccca gtggctccgg aaatcacttc tgtggaatat   2100

ttcaacagtc tgttatatat cagttggaca tatggggatg atacaacgga cttgtcccat   2160

tctagaatgc ttcactggat ggtggttgca gaaggaaaaa agaaaattaa aaagagtgta   2220

acacgcaatg tcatgactgc aattctcagc ttgcctccag gcgacatcta taacctctca   2280

gtaactgctt gtactgaaag aggaagtaat acctccatgc tccgccttgt caagctagaa   2340

ccagctccac ccaaatcact cttcgcagtg aacaaaaccc agacttcagt gactttgctg   2400

tgggtggaag agggagtagc tgatttcttt gaagttttct gtcaacaagt tggctccagt   2460

cagaaaacca aacttcagga accagttgct gtttcttccc atgtcgtgac catctccagc   2520

cttcttcctg ccactgccta caattgtagt gtcaccagct ttagccatga cagccccagt   2580

gtccctacgt tcatagccgt ctcaacaatg gttacagaga tgaatcccaa tgtggtagtg   2640

atctccgtgc tggccatcct tagcacactt ttaattggac tgttgcttgt taccctcatt   2700

attcttagga aaaagcatct gcagatggct agggagtgtg gagctggtac atttgtcaat   2760

tttgcatcct tagagaggga tggaaagctt ccatacaact ggagtaaaaa tggtttaaag   2820

aagaggaaac tgacaaaccc ggttcaactg gatgactttg atgcctatat taaggatatg   2880

gccaaagact ctgactataa attttctctt cagtttgagg agttgaaatt gattggactg   2940

gatatcccac actttgctgc agatcttcca ctgaatcgat gtaaaaaccg ttacacaaac   3000

atcctaccat atgacttcag ccgtgtgaga ttagtctcca tgaatgaaga ggaaggtgca   3060

gactacatca atgccaacta tattcctgga tacaactcac cccaggagta tattgccacc   3120

caggggccac tgcctgaaac cagaaatgac ttctggaaga tggtcctgca acaaaagtct   3180

cagattattg tcatgctcac tcagtgtaat gagaaaagga gggtgaaatg tgaccattac   3240

tggccattca cggaagaacc tatagcctat ggagacatca ctgtggagat gatttcagag   3300

gaagagcagg acgactgggc ctgtagacac ttccggatca actatgctga cgagatgcag   3360

gatgtgatgc attttaacta cactgcatgg cctgatcatg gtgtgcccac agcaaatgct   3420

gcagaaagta tcctgcagtt tgtacacatg gtccgacagc aagctaccaa gagcaaaggt   3480

cccatgatca ttcactgcag tgctggcgtg ggacggacag gaacattcat tgccctggac   3540

aggctcttgc agcacattcg ggatcatgag tttgttgaca tcttagggct ggtgtcagaa   3600

atgaggtcat accggatgtc tatggtacag acagaggagc agtacatttt tatccatcag   3660

tgtgtgcaac tgatgtggat gaagaagaag cagcagttct gcatcagtga tgtcatatac   3720

gagaatgtta gcaagtccta gttcagaatc cggagcagag aggacatgat gtgcgcccat   3780

cctcccttgc ttccagattg ttttagtggg ccctgatggt catttttcta aacagaggcc   3840

ctgctttgta atatgtggcc aaggagataa tttatctcac agaagcaccg ggaagactta   3900

gccttaaaga gcctacagtg tccttttgga ctctttcact tcgggacatt taataatgga   3960

ccaaattcaa cagaacacca ggaaggtcaa gacgctctcc aaagggcagg aagtacagca   4020

cttccgaaga gtttagttgg ccctttgctg gttgggctga gttttttatt tttaagtgtt   4080

tgtttttcag tgcaataatt tttgtgtgtg tgtgattctt atcagaaagt tgaattgttt   4140

tctgcctaca ccgttcatca gccccataac ccaggaagga acaggcattg ttagcatcag   4200

attatacctc attattaaaa ggaggcatgg ccacacatga agaaatggtc attctacttc   4260

aaagaaattg agccagcact atctgtactc caacattacc ggatctggat tggggaggtt   4320

ggtcagggaa gagaggggtt ctacccacag atcaactgtg taatctttta ctattcaagc   4380

tataattcag cttcaaagta gagtagaaaa aaaattgtct taactgttct agttcttgat   4440

ggttttcttc cttattaaca gttggtgttt cttccttggc ccttttggac taatgttact   4500

gtccaagttc tttctcaaga aaccacatct ggttcagaag agtgtcaagt tggactcttt   4560

gaactctgtt gctgtctgag caatcgtggt gcctagactt tgcattcctt gttctgttga   4620

cctgcataca tgtgagagct atttctttaa gaactatata ggctgtgaaa acgcactttc   4680

tttcccccaa agagctggga atttatgaag ttatggcaat gaactgcagc atgctgggac   4740

aattatttga ctactttttt ttgtaatatt gtcaaatgtc tctatggatt ctgacagaga   4800

tttctttttg ttttgttatt cttttggttg tcagtttcat tttaacgagt gtaactagta   4860

acattttatt ctttggattt tgtataatta cagtacatga ttgtgtattg tgacatgaat   4920

gctgtcaaaa tgacattgat ggcattgtga agcctgttac tttgtgtcac ttcctgataa   4980

ataagaggtg atgacatgga tatacaacag aaaacacttt gagttgaaag taaacacaag   5040

ctggctgctt ccctgtggca actgtggct                                     5069


<210>  2941
<211>  1188
<212>  PRT
<213>  Homosapiens

<400>  2941

Met Gly His Leu Pro Thr Gly Ile His Gly Ala Arg Arg Leu Leu Pro 
1               5                   10                  15      


Leu Leu Trp Leu Phe Val Leu Phe Lys Asn Ala Thr Ala Phe His Val 
            20                  25                  30          


Thr Val Gln Asp Asp Asn Asn Ile Val Val Ser Leu Glu Ala Ser Asp 
        35                  40                  45              


Val Ile Ser Pro Ala Ser Val Tyr Val Val Lys Ile Thr Gly Glu Ser 
    50                  55                  60                  


Lys Asn Tyr Phe Phe Glu Phe Glu Glu Phe Asn Ser Thr Leu Pro Pro 
65                  70                  75                  80  


Pro Val Ile Phe Lys Ala Ser Tyr His Gly Leu Tyr Tyr Ile Ile Thr 
                85                  90                  95      


Leu Val Val Val Asn Gly Asn Val Val Thr Lys Pro Ser Arg Ser Ile 
            100                 105                 110         


Thr Val Leu Thr Lys Pro Leu Pro Val Thr Ser Val Ser Ile Tyr Asp 
        115                 120                 125             


Tyr Lys Pro Ser Pro Glu Thr Gly Val Leu Phe Glu Ile His Tyr Pro 
    130                 135                 140                 


Glu Lys Tyr Asn Val Phe Thr Arg Val Asn Ile Ser Tyr Trp Glu Gly 
145                 150                 155                 160 


Lys Asp Phe Arg Thr Met Leu Tyr Lys Asp Phe Phe Lys Gly Lys Thr 
                165                 170                 175     


Val Phe Asn His Trp Leu Pro Gly Met Cys Tyr Ser Asn Ile Thr Phe 
            180                 185                 190         


Gln Leu Val Ser Glu Ala Thr Phe Asn Lys Ser Thr Leu Val Glu Tyr 
        195                 200                 205             


Ser Gly Val Ser His Glu Pro Lys Gln His Arg Thr Ala Pro Tyr Pro 
    210                 215                 220                 


Pro Gln Asn Ile Ser Val Arg Ile Val Asn Leu Asn Lys Asn Asn Trp 
225                 230                 235                 240 


Glu Glu Gln Ser Gly Asn Phe Pro Glu Glu Ser Phe Met Arg Ser Gln 
                245                 250                 255     


Asp Thr Ile Gly Lys Glu Lys Leu Phe His Phe Thr Glu Glu Thr Pro 
            260                 265                 270         


Glu Ile Pro Ser Gly Asn Ile Ser Ser Gly Trp Pro Asp Phe Asn Ser 
        275                 280                 285             


Ser Asp Tyr Glu Thr Thr Ser Gln Pro Tyr Trp Trp Asp Ser Ala Ser 
    290                 295                 300                 


Ala Ala Pro Glu Ser Glu Asp Glu Phe Val Ser Val Leu Pro Met Glu 
305                 310                 315                 320 


Tyr Glu Asn Asn Ser Thr Leu Ser Glu Thr Glu Lys Ser Thr Ser Gly 
                325                 330                 335     


Ser Phe Ser Phe Phe Pro Val Gln Met Ile Leu Thr Trp Leu Pro Pro 
            340                 345                 350         


Lys Pro Pro Thr Ala Phe Asp Gly Phe His Ile His Ile Glu Arg Glu 
        355                 360                 365             


Glu Asn Phe Thr Glu Tyr Leu Met Val Asp Glu Glu Ala His Glu Phe 
    370                 375                 380                 


Val Ala Glu Leu Lys Glu Pro Gly Lys Tyr Lys Leu Ser Val Thr Thr 
385                 390                 395                 400 


Phe Ser Ser Ser Gly Ser Cys Glu Thr Arg Lys Ser Gln Ser Ala Lys 
                405                 410                 415     


Ser Leu Ser Phe Tyr Ile Ser Pro Ser Gly Glu Trp Ile Glu Glu Leu 
            420                 425                 430         


Thr Glu Lys Pro Gln His Val Ser Val His Val Leu Ser Ser Thr Thr 
        435                 440                 445             


Ala Leu Met Ser Trp Thr Ser Ser Gln Glu Asn Tyr Asn Ser Thr Ile 
    450                 455                 460                 


Val Ser Val Val Ser Leu Thr Cys Gln Lys Gln Lys Glu Ser Gln Arg 
465                 470                 475                 480 


Leu Glu Lys Gln Tyr Cys Thr Gln Val Asn Ser Ser Lys Pro Ile Ile 
                485                 490                 495     


Glu Asn Leu Val Pro Gly Ala Gln Tyr Gln Val Val Ile Tyr Leu Arg 
            500                 505                 510         


Lys Gly Pro Leu Ile Gly Pro Pro Ser Asp Pro Val Thr Phe Ala Ile 
        515                 520                 525             


Val Pro Thr Gly Ile Lys Asp Leu Met Leu Tyr Pro Leu Gly Pro Thr 
    530                 535                 540                 


Ala Val Val Leu Ser Trp Thr Arg Pro Tyr Leu Gly Val Phe Arg Lys 
545                 550                 555                 560 


Tyr Val Val Glu Met Phe Tyr Phe Asn Pro Ala Thr Met Thr Ser Glu 
                565                 570                 575     


Trp Thr Thr Tyr Tyr Glu Ile Ala Ala Thr Val Ser Leu Thr Ala Ser 
            580                 585                 590         


Val Arg Ile Ala Asn Leu Leu Pro Ala Trp Tyr Tyr Asn Phe Arg Val 
        595                 600                 605             


Thr Met Val Thr Trp Gly Asp Pro Glu Leu Ser Cys Cys Asp Ser Ser 
    610                 615                 620                 


Thr Ile Ser Phe Ile Thr Ala Pro Val Ala Pro Glu Ile Thr Ser Val 
625                 630                 635                 640 


Glu Tyr Phe Asn Ser Leu Leu Tyr Ile Ser Trp Thr Tyr Gly Asp Asp 
                645                 650                 655     


Thr Thr Asp Leu Ser His Ser Arg Met Leu His Trp Met Val Val Ala 
            660                 665                 670         


Glu Gly Lys Lys Lys Ile Lys Lys Ser Val Thr Arg Asn Val Met Thr 
        675                 680                 685             


Ala Ile Leu Ser Leu Pro Pro Gly Asp Ile Tyr Asn Leu Ser Val Thr 
    690                 695                 700                 


Ala Cys Thr Glu Arg Gly Ser Asn Thr Ser Met Leu Arg Leu Val Lys 
705                 710                 715                 720 


Leu Glu Pro Ala Pro Pro Lys Ser Leu Phe Ala Val Asn Lys Thr Gln 
                725                 730                 735     


Thr Ser Val Thr Leu Leu Trp Val Glu Glu Gly Val Ala Asp Phe Phe 
            740                 745                 750         


Glu Val Phe Cys Gln Gln Val Gly Ser Ser Gln Lys Thr Lys Leu Gln 
        755                 760                 765             


Glu Pro Val Ala Val Ser Ser His Val Val Thr Ile Ser Ser Leu Leu 
    770                 775                 780                 


Pro Ala Thr Ala Tyr Asn Cys Ser Val Thr Ser Phe Ser His Asp Ser 
785                 790                 795                 800 


Pro Ser Val Pro Thr Phe Ile Ala Val Ser Thr Met Val Thr Glu Met 
                805                 810                 815     


Asn Pro Asn Val Val Val Ile Ser Val Leu Ala Ile Leu Ser Thr Leu 
            820                 825                 830         


Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile Leu Arg Lys Lys His 
        835                 840                 845             


Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr Phe Val Asn Phe Ala 
    850                 855                 860                 


Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn Trp Ser Lys Asn Gly 
865                 870                 875                 880 


Leu Lys Lys Arg Lys Leu Thr Asn Pro Val Gln Leu Asp Asp Phe Asp 
                885                 890                 895     


Ala Tyr Ile Lys Asp Met Ala Lys Asp Ser Asp Tyr Lys Phe Ser Leu 
            900                 905                 910         


Gln Phe Glu Glu Leu Lys Leu Ile Gly Leu Asp Ile Pro His Phe Ala 
        915                 920                 925             


Ala Asp Leu Pro Leu Asn Arg Cys Lys Asn Arg Tyr Thr Asn Ile Leu 
    930                 935                 940                 


Pro Tyr Asp Phe Ser Arg Val Arg Leu Val Ser Met Asn Glu Glu Glu 
945                 950                 955                 960 


Gly Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Pro Gly Tyr Asn Ser Pro 
                965                 970                 975     


Gln Glu Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Arg Asn Asp 
            980                 985                 990         


Phe Trp Lys Met Val Leu Gln Gln  Lys Ser Gln Ile Ile  Val Met Leu 
        995                 1000                 1005             


Thr Gln  Cys Asn Glu Lys Arg  Arg Val Lys Cys Asp  His Tyr Trp 
    1010                 1015                 1020             


Pro Phe  Thr Glu Glu Pro Ile  Ala Tyr Gly Asp Ile  Thr Val Glu 
    1025                 1030                 1035             


Met Ile  Ser Glu Glu Glu Gln  Asp Asp Trp Ala Cys  Arg His Phe 
    1040                 1045                 1050             


Arg Ile  Asn Tyr Ala Asp Glu  Met Gln Asp Val Met  His Phe Asn 
    1055                 1060                 1065             


Tyr Thr  Ala Trp Pro Asp His  Gly Val Pro Thr Ala  Asn Ala Ala 
    1070                 1075                 1080             


Glu Ser  Ile Leu Gln Phe Val  His Met Val Arg Gln  Gln Ala Thr 
    1085                 1090                 1095             


Lys Ser  Lys Gly Pro Met Ile  Ile His Cys Ser Ala  Gly Val Gly 
    1100                 1105                 1110             


Arg Thr  Gly Thr Phe Ile Ala  Leu Asp Arg Leu Leu  Gln His Ile 
    1115                 1120                 1125             


Arg Asp  His Glu Phe Val Asp  Ile Leu Gly Leu Val  Ser Glu Met 
    1130                 1135                 1140             


Arg Ser  Tyr Arg Met Ser Met  Val Gln Thr Glu Glu  Gln Tyr Ile 
    1145                 1150                 1155             


Phe Ile  His Gln Cys Val Gln  Leu Met Trp Met Lys  Lys Lys Gln 
    1160                 1165                 1170             


Gln Phe  Cys Ile Ser Asp Val  Ile Tyr Glu Asn Val  Ser Lys Ser 
    1175                 1180                 1185             


<210>  2942
<211>  5153
<212>  DNA
<213>  Homosapiens

<400>  2942
gggcgcagag gaggaaaggg agcaggcgca gggggactgg aaaggcagca tgcgctcgcc     60

aggagcaacc tcggcgccca gggtctgagg ctgcagcccc agttcgccat tgtgagccgc    120

cgccggggga gtccgctagc gcagccgtgc ccccgagtcc ccgtccgcgc agcgatgggg    180

cacctgccca cggggataca cggcgcccgc cgcctcctgc ctctgctctg gctctttgtg    240

ctgttcaaga atgctacagc tttccatgta actgtccaag atgataataa catcgttgtc    300

tcattagaag cttcagacgt catcagtcca gcatctgtgt atgttgtgaa gataactggt    360

gaatccaaaa attatttctt cgaatttgag gaattcaaca gcactttgcc tcctcctgtt    420

attttcaagg ccagttatca tggcctttat tatataatca ctctggtagt ggtaaatgga    480

aatgtggtga ccaagccatc cagatcaatc actgtgttaa caaaacctct acctgtaacc    540

agtgtttcca tatatgacta taaaccttct cctgaaacag gagtcctgtt tgaaatacat    600

tatccagaaa aatataacgt tttcacaaga gtgaacatta gctactggga aggtaaagac    660

ttccggacaa tgctatataa agatttcttt aagggaaaaa cagtatttaa tcactggctg    720

ccaggaatgt gttatagtaa tatcaccttt cagctggtat ctgaggcaac ttttaataaa    780

agtacccttg ttgagtacag tggtgtcagt cacgaaccca aacagcacag aactgcccct    840

tatccacctc aaaatatttc cgttcgtatc gtaaacttga acaaaaacaa ctgggaagaa    900

cagagtggca atttcccaga agaatccttc atgagatcac aagatacaat aggaaaagaa    960

aaactcttcc attttacaga agaaacccct gaaattccct cgggcaacat ttcttccggt   1020

tggcctgatt ttaatagcag tgactatgaa actacgtctc agccatattg gtgggacagt   1080

gcatctgcag ctcctgaaag tgaagatgaa tttgtcagcg tacttcccat ggaatacgaa   1140

aataacagta cactcagtga gacagagaag tcaacatcag gctctttctc ctttttccct   1200

gtgcaaatga tattgacctg gttaccaccc aaaccaccca ctgcttttga tgggttccat   1260

atccatattg aacgagaaga gaactttact gaatatttga tggtggatga agaagcacat   1320

gaatttgttg cagaactgaa ggaacctggg aaatataagt tatctgtgac aacctttagt   1380

tcctcaggat cttgtgaaac tcgaaaaagt cagtcagcaa aatcactcag cttttatatc   1440

agtccttcag gagagtggat tgaagaactg accgagaagc cgcagcacgt gagtgtccac   1500

gttttaagct caaccactgc cttgatgtcc tggacatctt cccaagagaa ctacaacagc   1560

accattgtgt ctgtggtgtc gctgacctgc cagaaacaaa aggagagcca gaggcttgaa   1620

aagcagtact gcactcaggt gaactcaagc aaacctatta ttgaaaatct ggttcctggt   1680

gcccagtacc aggttgtaat atacctaagg aaaggccctt tgattggacc accttcagat   1740

cctgtgacat ttgctattgt tcccacagga ataaaggatt taatgctcta tcctttgggt   1800

cctacggccg tggttctgag ctggaccaga ccttatttag gcgtgttcag aaaatacgtg   1860

gttgaaatgt tttatttcaa ccctgctaca atgacatcag agtggaccac ctactatgaa   1920

atagcagcaa ctgtttcctt aactgcatcc gtgagaatag ctaatctgct gccagcatgg   1980

tactacaact tccgggttac catggtgacg tggggagatc cagaattgag ctgctgtgac   2040

agctctacca tcagcttcat aacagcccca gtggctccgg aaatcacttc tgtggaatat   2100

ttcaacagtc tgttatatat cagttggaca tatggggatg atacaacgga cttgtcccat   2160

tctagaatgc ttcactggat ggtggttgca gaaggaaaaa agaaaattaa aaagagtgta   2220

acacgcaatg tcatgactgc aattctcagc ttgcctccag gcgacatcta taacctctca   2280

gtaactgctt gtactgaaag aggaagtaat acctccatgc tccgccttgt caagctagaa   2340

ccagctccac ccaaatcact cttcgcagtg aacaaaaccc agacttcagt gactttgctg   2400

tgggtggaag agggagtagc tgatttcttt gaagttttct gtcaacaagt tggctccagt   2460

cagaaaacca aacttcagga accagttgct gtttcttccc atgtcgtgac catctccagc   2520

cttcttcctg ccactgccta caattgtagt gtcaccagct ttagccatga cagccccagt   2580

gtccctacgt tcatagccgt ctcaacaatg gttacagaga tgaatcccaa tgtggtagtg   2640

atctccgtgc tggccatcct tagcacactt ttaattggac tgttgcttgt taccctcatt   2700

attcttagga aaaagcatct gcagatggct agggagtgtg gagctggtac atttgtcaat   2760

tttgcatcct tagagaggga tggaaagctt ccatacaact ggcgtaggag tatatttgct   2820

ttcttaaccc tgctaccctc atgtctttgg actgattatc ttttggcatt ttatattaat   2880

ccttggagta aaaatggttt aaagaagagg aaactgacaa acccggttca actggatgac   2940

tttgatgcct atattaagga tatggccaaa gactctgact ataaattttc tcttcagttt   3000

gaggagttga aattgattgg actggatatc ccacactttg ctgcagatct tccactgaat   3060

cgatgtaaaa accgttacac aaacatccta ccatatgact tcagccgtgt gagattagtc   3120

tccatgaatg aagaggaagg tgcagactac atcaatgcca actatattcc tggatacaac   3180

tcaccccagg agtatattgc cacccagggg ccactgcctg aaaccagaaa tgacttctgg   3240

aagatggtcc tgcaacaaaa gtctcagatt attgtcatgc tcactcagtg taatgagaaa   3300

aggagggtga aatgtgacca ttactggcca ttcacggaag aacctatagc ctatggagac   3360

atcactgtgg agatgatttc agaggaagag caggacgact gggcctgtag acacttccgg   3420

atcaactatg ctgacgagat gcaggatgtg atgcatttta actacactgc atggcctgat   3480

catggtgtgc ccacagcaaa tgctgcagaa agtatcctgc agtttgtaca catggtccga   3540

cagcaagcta ccaagagcaa aggtcccatg atcattcact gcagtgctgg cgtgggacgg   3600

acaggaacat tcattgccct ggacaggctc ttgcagcaca ttcgggatca tgagtttgtt   3660

gacatcttag ggctggtgtc agaaatgagg tcataccgga tgtctatggt acagacagag   3720

gagcagtaca tttttatcca tcagtgtgtg caactgatgt ggatgaagaa gaagcagcag   3780

ttctgcatca gtgatgtcat atacgagaat gttagcaagt cctagttcag aatccggagc   3840

agagaggaca tgatgtgcgc ccatcctccc ttgcttccag attgttttag tgggccctga   3900

tggtcatttt tctaaacaga ggccctgctt tgtaatatgt ggccaaggag ataatttatc   3960

tcacagaagc accgggaaga cttagcctta aagagcctac agtgtccttt tggactcttt   4020

cacttcggga catttaataa tggaccaaat tcaacagaac accaggaagg tcaagacgct   4080

ctccaaaggg caggaagtac agcacttccg aagagtttag ttggcccttt gctggttggg   4140

ctgagttttt tatttttaag tgtttgtttt tcagtgcaat aatttttgtg tgtgtgtgat   4200

tcttatcaga aagttgaatt gttttctgcc tacaccgttc atcagcccca taacccagga   4260

aggaacaggc attgttagca tcagattata cctcattatt aaaaggaggc atggccacac   4320

atgaagaaat ggtcattcta cttcaaagaa attgagccag cactatctgt actccaacat   4380

taccggatct ggattgggga ggttggtcag ggaagagagg ggttctaccc acagatcaac   4440

tgtgtaatct tttactattc aagctataat tcagcttcaa agtagagtag aaaaaaaatt   4500

gtcttaactg ttctagttct tgatggtttt cttccttatt aacagttggt gtttcttcct   4560

tggccctttt ggactaatgt tactgtccaa gttctttctc aagaaaccac atctggttca   4620

gaagagtgtc aagttggact ctttgaactc tgttgctgtc tgagcaatcg tggtgcctag   4680

actttgcatt ccttgttctg ttgacctgca tacatgtgag agctatttct ttaagaacta   4740

tataggctgt gaaaacgcac tttctttccc ccaaagagct gggaatttat gaagttatgg   4800

caatgaactg cagcatgctg ggacaattat ttgactactt ttttttgtaa tattgtcaaa   4860

tgtctctatg gattctgaca gagatttctt tttgttttgt tattcttttg gttgtcagtt   4920

tcattttaac gagtgtaact agtaacattt tattctttgg attttgtata attacagtac   4980

atgattgtgt attgtgacat gaatgctgtc aaaatgacat tgatggcatt gtgaagcctg   5040

ttactttgtg tcacttcctg ataaataaga ggtgatgaca tggatataca acagaaaaca   5100

ctttgagttg aaagtaaaca caagctggct gcttccctgt ggcaactgtg gct          5153


<210>  2943
<211>  1216
<212>  PRT
<213>  Homosapiens

<400>  2943

Met Gly His Leu Pro Thr Gly Ile His Gly Ala Arg Arg Leu Leu Pro 
1               5                   10                  15      


Leu Leu Trp Leu Phe Val Leu Phe Lys Asn Ala Thr Ala Phe His Val 
            20                  25                  30          


Thr Val Gln Asp Asp Asn Asn Ile Val Val Ser Leu Glu Ala Ser Asp 
        35                  40                  45              


Val Ile Ser Pro Ala Ser Val Tyr Val Val Lys Ile Thr Gly Glu Ser 
    50                  55                  60                  


Lys Asn Tyr Phe Phe Glu Phe Glu Glu Phe Asn Ser Thr Leu Pro Pro 
65                  70                  75                  80  


Pro Val Ile Phe Lys Ala Ser Tyr His Gly Leu Tyr Tyr Ile Ile Thr 
                85                  90                  95      


Leu Val Val Val Asn Gly Asn Val Val Thr Lys Pro Ser Arg Ser Ile 
            100                 105                 110         


Thr Val Leu Thr Lys Pro Leu Pro Val Thr Ser Val Ser Ile Tyr Asp 
        115                 120                 125             


Tyr Lys Pro Ser Pro Glu Thr Gly Val Leu Phe Glu Ile His Tyr Pro 
    130                 135                 140                 


Glu Lys Tyr Asn Val Phe Thr Arg Val Asn Ile Ser Tyr Trp Glu Gly 
145                 150                 155                 160 


Lys Asp Phe Arg Thr Met Leu Tyr Lys Asp Phe Phe Lys Gly Lys Thr 
                165                 170                 175     


Val Phe Asn His Trp Leu Pro Gly Met Cys Tyr Ser Asn Ile Thr Phe 
            180                 185                 190         


Gln Leu Val Ser Glu Ala Thr Phe Asn Lys Ser Thr Leu Val Glu Tyr 
        195                 200                 205             


Ser Gly Val Ser His Glu Pro Lys Gln His Arg Thr Ala Pro Tyr Pro 
    210                 215                 220                 


Pro Gln Asn Ile Ser Val Arg Ile Val Asn Leu Asn Lys Asn Asn Trp 
225                 230                 235                 240 


Glu Glu Gln Ser Gly Asn Phe Pro Glu Glu Ser Phe Met Arg Ser Gln 
                245                 250                 255     


Asp Thr Ile Gly Lys Glu Lys Leu Phe His Phe Thr Glu Glu Thr Pro 
            260                 265                 270         


Glu Ile Pro Ser Gly Asn Ile Ser Ser Gly Trp Pro Asp Phe Asn Ser 
        275                 280                 285             


Ser Asp Tyr Glu Thr Thr Ser Gln Pro Tyr Trp Trp Asp Ser Ala Ser 
    290                 295                 300                 


Ala Ala Pro Glu Ser Glu Asp Glu Phe Val Ser Val Leu Pro Met Glu 
305                 310                 315                 320 


Tyr Glu Asn Asn Ser Thr Leu Ser Glu Thr Glu Lys Ser Thr Ser Gly 
                325                 330                 335     


Ser Phe Ser Phe Phe Pro Val Gln Met Ile Leu Thr Trp Leu Pro Pro 
            340                 345                 350         


Lys Pro Pro Thr Ala Phe Asp Gly Phe His Ile His Ile Glu Arg Glu 
        355                 360                 365             


Glu Asn Phe Thr Glu Tyr Leu Met Val Asp Glu Glu Ala His Glu Phe 
    370                 375                 380                 


Val Ala Glu Leu Lys Glu Pro Gly Lys Tyr Lys Leu Ser Val Thr Thr 
385                 390                 395                 400 


Phe Ser Ser Ser Gly Ser Cys Glu Thr Arg Lys Ser Gln Ser Ala Lys 
                405                 410                 415     


Ser Leu Ser Phe Tyr Ile Ser Pro Ser Gly Glu Trp Ile Glu Glu Leu 
            420                 425                 430         


Thr Glu Lys Pro Gln His Val Ser Val His Val Leu Ser Ser Thr Thr 
        435                 440                 445             


Ala Leu Met Ser Trp Thr Ser Ser Gln Glu Asn Tyr Asn Ser Thr Ile 
    450                 455                 460                 


Val Ser Val Val Ser Leu Thr Cys Gln Lys Gln Lys Glu Ser Gln Arg 
465                 470                 475                 480 


Leu Glu Lys Gln Tyr Cys Thr Gln Val Asn Ser Ser Lys Pro Ile Ile 
                485                 490                 495     


Glu Asn Leu Val Pro Gly Ala Gln Tyr Gln Val Val Ile Tyr Leu Arg 
            500                 505                 510         


Lys Gly Pro Leu Ile Gly Pro Pro Ser Asp Pro Val Thr Phe Ala Ile 
        515                 520                 525             


Val Pro Thr Gly Ile Lys Asp Leu Met Leu Tyr Pro Leu Gly Pro Thr 
    530                 535                 540                 


Ala Val Val Leu Ser Trp Thr Arg Pro Tyr Leu Gly Val Phe Arg Lys 
545                 550                 555                 560 


Tyr Val Val Glu Met Phe Tyr Phe Asn Pro Ala Thr Met Thr Ser Glu 
                565                 570                 575     


Trp Thr Thr Tyr Tyr Glu Ile Ala Ala Thr Val Ser Leu Thr Ala Ser 
            580                 585                 590         


Val Arg Ile Ala Asn Leu Leu Pro Ala Trp Tyr Tyr Asn Phe Arg Val 
        595                 600                 605             


Thr Met Val Thr Trp Gly Asp Pro Glu Leu Ser Cys Cys Asp Ser Ser 
    610                 615                 620                 


Thr Ile Ser Phe Ile Thr Ala Pro Val Ala Pro Glu Ile Thr Ser Val 
625                 630                 635                 640 


Glu Tyr Phe Asn Ser Leu Leu Tyr Ile Ser Trp Thr Tyr Gly Asp Asp 
                645                 650                 655     


Thr Thr Asp Leu Ser His Ser Arg Met Leu His Trp Met Val Val Ala 
            660                 665                 670         


Glu Gly Lys Lys Lys Ile Lys Lys Ser Val Thr Arg Asn Val Met Thr 
        675                 680                 685             


Ala Ile Leu Ser Leu Pro Pro Gly Asp Ile Tyr Asn Leu Ser Val Thr 
    690                 695                 700                 


Ala Cys Thr Glu Arg Gly Ser Asn Thr Ser Met Leu Arg Leu Val Lys 
705                 710                 715                 720 


Leu Glu Pro Ala Pro Pro Lys Ser Leu Phe Ala Val Asn Lys Thr Gln 
                725                 730                 735     


Thr Ser Val Thr Leu Leu Trp Val Glu Glu Gly Val Ala Asp Phe Phe 
            740                 745                 750         


Glu Val Phe Cys Gln Gln Val Gly Ser Ser Gln Lys Thr Lys Leu Gln 
        755                 760                 765             


Glu Pro Val Ala Val Ser Ser His Val Val Thr Ile Ser Ser Leu Leu 
    770                 775                 780                 


Pro Ala Thr Ala Tyr Asn Cys Ser Val Thr Ser Phe Ser His Asp Ser 
785                 790                 795                 800 


Pro Ser Val Pro Thr Phe Ile Ala Val Ser Thr Met Val Thr Glu Met 
                805                 810                 815     


Asn Pro Asn Val Val Val Ile Ser Val Leu Ala Ile Leu Ser Thr Leu 
            820                 825                 830         


Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile Leu Arg Lys Lys His 
        835                 840                 845             


Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr Phe Val Asn Phe Ala 
    850                 855                 860                 


Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn Trp Arg Arg Ser Ile 
865                 870                 875                 880 


Phe Ala Phe Leu Thr Leu Leu Pro Ser Cys Leu Trp Thr Asp Tyr Leu 
                885                 890                 895     


Leu Ala Phe Tyr Ile Asn Pro Trp Ser Lys Asn Gly Leu Lys Lys Arg 
            900                 905                 910         


Lys Leu Thr Asn Pro Val Gln Leu Asp Asp Phe Asp Ala Tyr Ile Lys 
        915                 920                 925             


Asp Met Ala Lys Asp Ser Asp Tyr Lys Phe Ser Leu Gln Phe Glu Glu 
    930                 935                 940                 


Leu Lys Leu Ile Gly Leu Asp Ile Pro His Phe Ala Ala Asp Leu Pro 
945                 950                 955                 960 


Leu Asn Arg Cys Lys Asn Arg Tyr Thr Asn Ile Leu Pro Tyr Asp Phe 
                965                 970                 975     


Ser Arg Val Arg Leu Val Ser Met Asn Glu Glu Glu Gly Ala Asp Tyr 
            980                 985                 990         


Ile Asn Ala Asn Tyr Ile Pro Gly  Tyr Asn Ser Pro Gln  Glu Tyr Ile 
        995                 1000                 1005             


Ala Thr  Gln Gly Pro Leu Pro  Glu Thr Arg Asn Asp  Phe Trp Lys 
    1010                 1015                 1020             


Met Val  Leu Gln Gln Lys Ser  Gln Ile Ile Val Met  Leu Thr Gln 
    1025                 1030                 1035             


Cys Asn  Glu Lys Arg Arg Val  Lys Cys Asp His Tyr  Trp Pro Phe 
    1040                 1045                 1050             


Thr Glu  Glu Pro Ile Ala Tyr  Gly Asp Ile Thr Val  Glu Met Ile 
    1055                 1060                 1065             


Ser Glu  Glu Glu Gln Asp Asp  Trp Ala Cys Arg His  Phe Arg Ile 
    1070                 1075                 1080             


Asn Tyr  Ala Asp Glu Met Gln  Asp Val Met His Phe  Asn Tyr Thr 
    1085                 1090                 1095             


Ala Trp  Pro Asp His Gly Val  Pro Thr Ala Asn Ala  Ala Glu Ser 
    1100                 1105                 1110             


Ile Leu  Gln Phe Val His Met  Val Arg Gln Gln Ala  Thr Lys Ser 
    1115                 1120                 1125             


Lys Gly  Pro Met Ile Ile His  Cys Ser Ala Gly Val  Gly Arg Thr 
    1130                 1135                 1140             


Gly Thr  Phe Ile Ala Leu Asp  Arg Leu Leu Gln His  Ile Arg Asp 
    1145                 1150                 1155             


His Glu  Phe Val Asp Ile Leu  Gly Leu Val Ser Glu  Met Arg Ser 
    1160                 1165                 1170             


Tyr Arg  Met Ser Met Val Gln  Thr Glu Glu Gln Tyr  Ile Phe Ile 
    1175                 1180                 1185             


His Gln  Cys Val Gln Leu Met  Trp Met Lys Lys Lys  Gln Gln Phe 
    1190                 1195                 1200             


Cys Ile  Ser Asp Val Ile Tyr  Glu Asn Val Ser Lys  Ser 
    1205                 1210                 1215     


<210>  2944
<211>  2948
<212>  DNA
<213>  Homosapiens

<400>  2944
aagtaaaaaa atggaagggg gaaaaggcaa agtattctgc cttccaagtt agatagctat     60

ctttatgaaa ggacatattt caaaggcaat ataaagtctt tatggtgctc ttacctacct    120

atatttgaat tgggggatgc ttcacctgct tattagtgaa agaagaaaga atacacttag    180

taaattaaat tttttttaaa actttgtctt tgctcagaac cagctccacc caaatcactc    240

ttcgcagtga acaaaaccca gacttcagtg actttgctgt gggtggaaga gggagtagct    300

gatttctttg aagttttctg tcaacaagtt ggctccagtc agaaaaccaa acttcaggaa    360

ccagttgctg tttcttccca tgtcgtgacc atctccagcc ttcttcctgc cactgcctac    420

aattgtagtg tcaccagctt tagccatgac agccccagtg tccctacgtt catagccgtc    480

tcaacaatgg ttacagagat gaatcccaat gtggtagtga tctccgtgct ggccatcctt    540

agcacacttt taattggact gttgcttgtt accctcatta ttcttaggaa aaagcatctg    600

cagatggcta gggagtgtgg agctggtaca tttgtcaatt ttgcatcctt agagagggat    660

ggaaagcttc catacaactg gagtaaaaat ggtttaaaga agaggaaact gacaaacccg    720

gttcaactgg atgactttga tgcctatatt aaggatatgg ccaaagactc tgactataaa    780

ttttctcttc agtttgagga gttgaaattg attggactgg atatcccaca ctttgctgca    840

gatcttccac tgaatcgatg taaaaaccgt tacacaaaca tcctaccata tgacttcagc    900

cgtgtgagat tagtctccat gaatgaagag gaaggtgcag actacatcaa tgccaactat    960

attcctggat acaactcacc ccaggagtat attgccaccc aggggccact gcctgaaacc   1020

agaaatgact tctggaagat ggtcctgcaa caaaagtctc agattattgt catgctcact   1080

cagtgtaatg agaaaaggag ggtgaaatgt gaccattact ggccattcac ggaagaacct   1140

atagcctatg gagacatcac tgtggagatg atttcagagg aagagcagga cgactgggcc   1200

tgtagacact tccggatcaa ctatgctgac gagatgcagg atgtgatgca ttttaactac   1260

actgcatggc ctgatcatgg tgtgcccaca gcaaatgctg cagaaagtat cctgcagttt   1320

gtacacatgg tccgacagca agctaccaag agcaaaggtc ccatgatcat tcactgcagt   1380

gctggcgtgg gacggacagg aacattcatt gccctggaca ggctcttgca gcacattcgg   1440

gatcatgagt ttgttgacat cttagggctg gtgtcagaaa tgaggtcata ccggatgtct   1500

atggtacaga cagaggagca gtacattttt atccatcagt gtgtgcaact gatgtggatg   1560

aagaagaagc agcagttctg catcagtgat gtcatatacg agaatgttag caagtcctag   1620

ttcagaatcc ggagcagaga ggacatgatg tgcgcccatc ctcccttgct tccagattgt   1680

tttagtgggc cctgatggtc atttttctaa acagaggccc tgctttgtaa tatgtggcca   1740

aggagataat ttatctcaca gaagcaccgg gaagacttag ccttaaagag cctacagtgt   1800

ccttttggac tctttcactt cgggacattt aataatggac caaattcaac agaacaccag   1860

gaaggtcaag acgctctcca aagggcagga agtacagcac ttccgaagag tttagttggc   1920

cctttgctgg ttgggctgag ttttttattt ttaagtgttt gtttttcagt gcaataattt   1980

ttgtgtgtgt gtgattctta tcagaaagtt gaattgtttt ctgcctacac cgttcatcag   2040

ccccataacc caggaaggaa caggcattgt tagcatcaga ttatacctca ttattaaaag   2100

gaggcatggc cacacatgaa gaaatggtca ttctacttca aagaaattga gccagcacta   2160

tctgtactcc aacattaccg gatctggatt ggggaggttg gtcagggaag agaggggttc   2220

tacccacaga tcaactgtgt aatcttttac tattcaagct ataattcagc ttcaaagtag   2280

agtagaaaaa aaattgtctt aactgttcta gttcttgatg gttttcttcc ttattaacag   2340

ttggtgtttc ttccttggcc cttttggact aatgttactg tccaagttct ttctcaagaa   2400

accacatctg gttcagaaga gtgtcaagtt ggactctttg aactctgttg ctgtctgagc   2460

aatcgtggtg cctagacttt gcattccttg ttctgttgac ctgcatacat gtgagagcta   2520

tttctttaag aactatatag gctgtgaaaa cgcactttct ttcccccaaa gagctgggaa   2580

tttatgaagt tatggcaatg aactgcagca tgctgggaca attatttgac tacttttttt   2640

tgtaatattg tcaaatgtct ctatggattc tgacagagat ttctttttgt tttgttattc   2700

ttttggttgt cagtttcatt ttaacgagtg taactagtaa cattttattc tttggatttt   2760

gtataattac agtacatgat tgtgtattgt gacatgaatg ctgtcaaaat gacattgatg   2820

gcattgtgaa gcctgttact ttgtgtcact tcctgataaa taagaggtga tgacatggat   2880

atacaacaga aaacactttg agttgaaagt aaacacaagc tggctgcttc cctgtggcaa   2940

ctgtggct                                                            2948


<210>  2945
<211>  377
<212>  PRT
<213>  Homosapiens

<400>  2945

Met Val Thr Glu Met Asn Pro Asn Val Val Val Ile Ser Val Leu Ala 
1               5                   10                  15      


Ile Leu Ser Thr Leu Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile 
            20                  25                  30          


Leu Arg Lys Lys His Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr 
        35                  40                  45              


Phe Val Asn Phe Ala Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn 
    50                  55                  60                  


Trp Ser Lys Asn Gly Leu Lys Lys Arg Lys Leu Thr Asn Pro Val Gln 
65                  70                  75                  80  


Leu Asp Asp Phe Asp Ala Tyr Ile Lys Asp Met Ala Lys Asp Ser Asp 
                85                  90                  95      


Tyr Lys Phe Ser Leu Gln Phe Glu Glu Leu Lys Leu Ile Gly Leu Asp 
            100                 105                 110         


Ile Pro His Phe Ala Ala Asp Leu Pro Leu Asn Arg Cys Lys Asn Arg 
        115                 120                 125             


Tyr Thr Asn Ile Leu Pro Tyr Asp Phe Ser Arg Val Arg Leu Val Ser 
    130                 135                 140                 


Met Asn Glu Glu Glu Gly Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Pro 
145                 150                 155                 160 


Gly Tyr Asn Ser Pro Gln Glu Tyr Ile Ala Thr Gln Gly Pro Leu Pro 
                165                 170                 175     


Glu Thr Arg Asn Asp Phe Trp Lys Met Val Leu Gln Gln Lys Ser Gln 
            180                 185                 190         


Ile Ile Val Met Leu Thr Gln Cys Asn Glu Lys Arg Arg Val Lys Cys 
        195                 200                 205             


Asp His Tyr Trp Pro Phe Thr Glu Glu Pro Ile Ala Tyr Gly Asp Ile 
    210                 215                 220                 


Thr Val Glu Met Ile Ser Glu Glu Glu Gln Asp Asp Trp Ala Cys Arg 
225                 230                 235                 240 


His Phe Arg Ile Asn Tyr Ala Asp Glu Met Gln Asp Val Met His Phe 
                245                 250                 255     


Asn Tyr Thr Ala Trp Pro Asp His Gly Val Pro Thr Ala Asn Ala Ala 
            260                 265                 270         


Glu Ser Ile Leu Gln Phe Val His Met Val Arg Gln Gln Ala Thr Lys 
        275                 280                 285             


Ser Lys Gly Pro Met Ile Ile His Cys Ser Ala Gly Val Gly Arg Thr 
    290                 295                 300                 


Gly Thr Phe Ile Ala Leu Asp Arg Leu Leu Gln His Ile Arg Asp His 
305                 310                 315                 320 


Glu Phe Val Asp Ile Leu Gly Leu Val Ser Glu Met Arg Ser Tyr Arg 
                325                 330                 335     


Met Ser Met Val Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Gln Cys 
            340                 345                 350         


Val Gln Leu Met Trp Met Lys Lys Lys Gln Gln Phe Cys Ile Ser Asp 
        355                 360                 365             


Val Ile Tyr Glu Asn Val Ser Lys Ser 
    370                 375         


<210>  2946
<211>  3032
<212>  DNA
<213>  Homosapiens

<400>  2946
aagtaaaaaa atggaagggg gaaaaggcaa agtattctgc cttccaagtt agatagctat     60

ctttatgaaa ggacatattt caaaggcaat ataaagtctt tatggtgctc ttacctacct    120

atatttgaat tgggggatgc ttcacctgct tattagtgaa agaagaaaga atacacttag    180

taaattaaat tttttttaaa actttgtctt tgctcagaac cagctccacc caaatcactc    240

ttcgcagtga acaaaaccca gacttcagtg actttgctgt gggtggaaga gggagtagct    300

gatttctttg aagttttctg tcaacaagtt ggctccagtc agaaaaccaa acttcaggaa    360

ccagttgctg tttcttccca tgtcgtgacc atctccagcc ttcttcctgc cactgcctac    420

aattgtagtg tcaccagctt tagccatgac agccccagtg tccctacgtt catagccgtc    480

tcaacaatgg ttacagagat gaatcccaat gtggtagtga tctccgtgct ggccatcctt    540

agcacacttt taattggact gttgcttgtt accctcatta ttcttaggaa aaagcatctg    600

cagatggcta gggagtgtgg agctggtaca tttgtcaatt ttgcatcctt agagagggat    660

ggaaagcttc catacaactg gcgtaggagt atatttgctt tcttaaccct gctaccctca    720

tgtctttgga ctgattatct tttggcattt tatattaatc cttggagtaa aaatggttta    780

aagaagagga aactgacaaa cccggttcaa ctggatgact ttgatgccta tattaaggat    840

atggccaaag actctgacta taaattttct cttcagtttg aggagttgaa attgattgga    900

ctggatatcc cacactttgc tgcagatctt ccactgaatc gatgtaaaaa ccgttacaca    960

aacatcctac catatgactt cagccgtgtg agattagtct ccatgaatga agaggaaggt   1020

gcagactaca tcaatgccaa ctatattcct ggatacaact caccccagga gtatattgcc   1080

acccaggggc cactgcctga aaccagaaat gacttctgga agatggtcct gcaacaaaag   1140

tctcagatta ttgtcatgct cactcagtgt aatgagaaaa ggagggtgaa atgtgaccat   1200

tactggccat tcacggaaga acctatagcc tatggagaca tcactgtgga gatgatttca   1260

gaggaagagc aggacgactg ggcctgtaga cacttccgga tcaactatgc tgacgagatg   1320

caggatgtga tgcattttaa ctacactgca tggcctgatc atggtgtgcc cacagcaaat   1380

gctgcagaaa gtatcctgca gtttgtacac atggtccgac agcaagctac caagagcaaa   1440

ggtcccatga tcattcactg cagtgctggc gtgggacgga caggaacatt cattgccctg   1500

gacaggctct tgcagcacat tcgggatcat gagtttgttg acatcttagg gctggtgtca   1560

gaaatgaggt cataccggat gtctatggta cagacagagg agcagtacat ttttatccat   1620

cagtgtgtgc aactgatgtg gatgaagaag aagcagcagt tctgcatcag tgatgtcata   1680

tacgagaatg ttagcaagtc ctagttcaga atccggagca gagaggacat gatgtgcgcc   1740

catcctccct tgcttccaga ttgttttagt gggccctgat ggtcattttt ctaaacagag   1800

gccctgcttt gtaatatgtg gccaaggaga taatttatct cacagaagca ccgggaagac   1860

ttagccttaa agagcctaca gtgtcctttt ggactctttc acttcgggac atttaataat   1920

ggaccaaatt caacagaaca ccaggaaggt caagacgctc tccaaagggc aggaagtaca   1980

gcacttccga agagtttagt tggccctttg ctggttgggc tgagtttttt atttttaagt   2040

gtttgttttt cagtgcaata atttttgtgt gtgtgtgatt cttatcagaa agttgaattg   2100

ttttctgcct acaccgttca tcagccccat aacccaggaa ggaacaggca ttgttagcat   2160

cagattatac ctcattatta aaaggaggca tggccacaca tgaagaaatg gtcattctac   2220

ttcaaagaaa ttgagccagc actatctgta ctccaacatt accggatctg gattggggag   2280

gttggtcagg gaagagaggg gttctaccca cagatcaact gtgtaatctt ttactattca   2340

agctataatt cagcttcaaa gtagagtaga aaaaaaattg tcttaactgt tctagttctt   2400

gatggttttc ttccttatta acagttggtg tttcttcctt ggcccttttg gactaatgtt   2460

actgtccaag ttctttctca agaaaccaca tctggttcag aagagtgtca agttggactc   2520

tttgaactct gttgctgtct gagcaatcgt ggtgcctaga ctttgcattc cttgttctgt   2580

tgacctgcat acatgtgaga gctatttctt taagaactat ataggctgtg aaaacgcact   2640

ttctttcccc caaagagctg ggaatttatg aagttatggc aatgaactgc agcatgctgg   2700

gacaattatt tgactacttt tttttgtaat attgtcaaat gtctctatgg attctgacag   2760

agatttcttt ttgttttgtt attcttttgg ttgtcagttt cattttaacg agtgtaacta   2820

gtaacatttt attctttgga ttttgtataa ttacagtaca tgattgtgta ttgtgacatg   2880

aatgctgtca aaatgacatt gatggcattg tgaagcctgt tactttgtgt cacttcctga   2940

taaataagag gtgatgacat ggatatacaa cagaaaacac tttgagttga aagtaaacac   3000

aagctggctg cttccctgtg gcaactgtgg ct                                 3032


<210>  2947
<211>  405
<212>  PRT
<213>  Homosapiens

<400>  2947

Met Val Thr Glu Met Asn Pro Asn Val Val Val Ile Ser Val Leu Ala 
1               5                   10                  15      


Ile Leu Ser Thr Leu Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile 
            20                  25                  30          


Leu Arg Lys Lys His Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr 
        35                  40                  45              


Phe Val Asn Phe Ala Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn 
    50                  55                  60                  


Trp Arg Arg Ser Ile Phe Ala Phe Leu Thr Leu Leu Pro Ser Cys Leu 
65                  70                  75                  80  


Trp Thr Asp Tyr Leu Leu Ala Phe Tyr Ile Asn Pro Trp Ser Lys Asn 
                85                  90                  95      


Gly Leu Lys Lys Arg Lys Leu Thr Asn Pro Val Gln Leu Asp Asp Phe 
            100                 105                 110         


Asp Ala Tyr Ile Lys Asp Met Ala Lys Asp Ser Asp Tyr Lys Phe Ser 
        115                 120                 125             


Leu Gln Phe Glu Glu Leu Lys Leu Ile Gly Leu Asp Ile Pro His Phe 
    130                 135                 140                 


Ala Ala Asp Leu Pro Leu Asn Arg Cys Lys Asn Arg Tyr Thr Asn Ile 
145                 150                 155                 160 


Leu Pro Tyr Asp Phe Ser Arg Val Arg Leu Val Ser Met Asn Glu Glu 
                165                 170                 175     


Glu Gly Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Pro Gly Tyr Asn Ser 
            180                 185                 190         


Pro Gln Glu Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Arg Asn 
        195                 200                 205             


Asp Phe Trp Lys Met Val Leu Gln Gln Lys Ser Gln Ile Ile Val Met 
    210                 215                 220                 


Leu Thr Gln Cys Asn Glu Lys Arg Arg Val Lys Cys Asp His Tyr Trp 
225                 230                 235                 240 


Pro Phe Thr Glu Glu Pro Ile Ala Tyr Gly Asp Ile Thr Val Glu Met 
                245                 250                 255     


Ile Ser Glu Glu Glu Gln Asp Asp Trp Ala Cys Arg His Phe Arg Ile 
            260                 265                 270         


Asn Tyr Ala Asp Glu Met Gln Asp Val Met His Phe Asn Tyr Thr Ala 
        275                 280                 285             


Trp Pro Asp His Gly Val Pro Thr Ala Asn Ala Ala Glu Ser Ile Leu 
    290                 295                 300                 


Gln Phe Val His Met Val Arg Gln Gln Ala Thr Lys Ser Lys Gly Pro 
305                 310                 315                 320 


Met Ile Ile His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile 
                325                 330                 335     


Ala Leu Asp Arg Leu Leu Gln His Ile Arg Asp His Glu Phe Val Asp 
            340                 345                 350         


Ile Leu Gly Leu Val Ser Glu Met Arg Ser Tyr Arg Met Ser Met Val 
        355                 360                 365             


Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Gln Cys Val Gln Leu Met 
    370                 375                 380                 


Trp Met Lys Lys Lys Gln Gln Phe Cys Ile Ser Asp Val Ile Tyr Glu 
385                 390                 395                 400 


Asn Val Ser Lys Ser 
                405 


<210>  2948
<211>  3980
<212>  DNA
<213>  Homosapiens

<400>  2948
aagtaaaaaa atggaagggg gaaaaggcaa agtattctgc cttccaagtt agatagctat     60

ctttatgaaa ggacatattt caaaggcaat ataaagtctt tatggtgctc ttacctacct    120

atatttgaat tgggggatgc ttcacctgct tattagtgaa agaagaaaga atacacttag    180

taaattaaat tttttttaaa actttgtctt tgctcagaac cagctccacc caaatcactc    240

ttcgcagtga acaaaaccca gacttcagtg actttgctgt gggtggaaga gggagtagct    300

gatttctttg aagttttctg tcaacaagtt ggctccagtc agaaaaccaa acttcaggaa    360

ccagttgctg tttcttccca tgtcgtgacc atctccagcc ttcttcctgc cactgcctac    420

aattgtagtg tcaccagctt tagccatgac agccccagtg tccctacgtt catagccgtc    480

tcaacaatgg ttacagagat gaatcccaat gtggtagtga tctccgtgct ggccatcctt    540

agcacacttt taattggact gttgcttgtt accctcatta ttcttaggaa aaagcatctg    600

cagatggcta gggagtgtgg agctggtaca tttgtcaatt ttgcatcctt agagagggat    660

ggaaagcttc catacaactg gagtaaaaat ggtttaaaga agaggaaact gacaaacccg    720

gttcaactgg atgactttga tgcctatatt aaggatatgg ccaaagactc tgactataaa    780

ttttctcttc agtttgagga gttgaaattg attggactgg atatcccaca ctttgctgca    840

gatcttccac tgaatcgatg taaaaaccgt tacacaaaca tcctaccata tgacttcagc    900

cgtgtgagat tagtctccat gaatgaagag gaaggtgcag actacatcaa tgccaactat    960

attcctggat acaactcacc ccaggagtat attgccaccc aggggccact gcctgaaacc   1020

agaaatgact tctggaagat ggtcctgcaa caaaagtctc agattattgt catgctcact   1080

cagtgtaatg agaaaaggag ggtgaaatgt gaccattact ggccattcac ggaagaacct   1140

atagcctatg gagacatcac tgtggagatg atttcagagg aagagcagga cgactgggcc   1200

tgtagacact tccggatcaa ctatgctgac gagatgcagg atgtgatgca ttttaactac   1260

actgcatggc ctgatcatgg tgtgcccaca gcaaatgctg cagaaagtat cctgcagttt   1320

gtacacatgg tccgacagca agctaccaag agcaaaggtc ccatgatcat tcactgcagt   1380

gctggcgtgg gacggacagg aacattcatt gccctggaca ggctcttgca gcacattcgg   1440

gatcatgagt ttgttgacat cttagggctg gtgtcagaaa tgaggtcata ccggatgtct   1500

atggtacaga cagaggagca gtacattttt atccatcagt gtgtgcaact gatgtggatg   1560

aagaagaagc agcagttctg catcagtgat gtcatatacg agaatgttag caagtcctag   1620

ttcagaatcc ggagcagtaa gtggagaaga gctctccacg agtgttcagt cttagaacta   1680

ttagaggggg atgtgatgga tgggacaaaa gacagcagta gccatttgta ttgactctga   1740

cttcacatga gtatttcttc ccagctcctg gcctcacatg ggtggtcaca gggagaaaca   1800

agtactgtag cagatctttg agtttcaatg caccttggtt ggtgttggca acaaacagga   1860

gcttctgcac atcatgatga ctttacctcc attccctcta cccagaaccc taaattattc   1920

tgttattgga tctgtgcctg taatatcagg atactaccat ccaaatctat ctagatatct   1980

tgtgcaaata ttttattgat tacaagggct gtatacgggg ttacaaaaag acatgagctg   2040

gattggacac tcctaaaacc aaaaacaaca gtgacaatag agtctcagga tagcagagtc   2100

tgaaaatacc ttggtctccc ccattatgtg agcccttatt tgagagcttc atgaagacac   2160

ttgtaacata ttcaacgtcc tgtactccag ttttgactac gagatcagat tttggaggtg   2220

taagtaatct tggctgaggt aacagtaatc tgcccattta gttcagtaaa cagactgtag   2280

agtgtctgac tatactgggg gaagaggagc caatgacagg gtagggagat gacagtggtg   2340

catgatggga gaatcatgaa agtctgggaa gcatatggac cagtgggaag gataggatta   2400

gcactgcacc tctacatcca tcaagagaga cagagcgcac aatggagcag gaaggataaa   2460

aaataaagaa agacagagac aaacaaattt gctgggagag ggaaagacat tcagacccac   2520

agaaaggagg cagcacacag agaaagatgc acagatcaac ccacatctgc atgggttgtg   2580

agactgagca tagtgagagc agtggtggag caatagaaga ttgctgtgac accaggctgc   2640

ttactgtctt tctttgtctc attcacagga gaggacatga tgtgcgccca tcctcccttg   2700

cttccagatt gttttagtgg gccctgatgg tcatttttct aaacagaggc cctgctttgt   2760

aatatgtggc caaggagata atttatctca cagaagcacc gggaagactt agccttaaag   2820

agcctacagt gtccttttgg actctttcac ttcgggacat ttaataatgg accaaattca   2880

acagaacacc aggaaggtca agacgctctc caaagggcag gaagtacagc acttccgaag   2940

agtttagttg gccctttgct ggttgggctg agttttttat ttttaagtgt ttgtttttca   3000

gtgcaataat ttttgtgtgt gtgtgattct tatcagaaag ttgaattgtt ttctgcctac   3060

accgttcatc agccccataa cccaggaagg aacaggcatt gttagcatca gattatacct   3120

cattattaaa aggaggcatg gccacacatg aagaaatggt cattctactt caaagaaatt   3180

gagccagcac tatctgtact ccaacattac cggatctgga ttggggaggt tggtcaggga   3240

agagaggggt tctacccaca gatcaactgt gtaatctttt actattcaag ctataattca   3300

gcttcaaagt agagtagaaa aaaaattgtc ttaactgttc tagttcttga tggttttctt   3360

ccttattaac agttggtgtt tcttccttgg cccttttgga ctaatgttac tgtccaagtt   3420

ctttctcaag aaaccacatc tggttcagaa gagtgtcaag ttggactctt tgaactctgt   3480

tgctgtctga gcaatcgtgg tgcctagact ttgcattcct tgttctgttg acctgcatac   3540

atgtgagagc tatttcttta agaactatat aggctgtgaa aacgcacttt ctttccccca   3600

aagagctggg aatttatgaa gttatggcaa tgaactgcag catgctggga caattatttg   3660

actacttttt tttgtaatat tgtcaaatgt ctctatggat tctgacagag atttcttttt   3720

gttttgttat tcttttggtt gtcagtttca ttttaacgag tgtaactagt aacattttat   3780

tctttggatt ttgtataatt acagtacatg attgtgtatt gtgacatgaa tgctgtcaaa   3840

atgacattga tggcattgtg aagcctgtta ctttgtgtca cttcctgata aataagaggt   3900

gatgacatgg atatacaaca gaaaacactt tgagttgaaa gtaaacacaa gctggctgct   3960

tccctgtggc aactgtggct                                               3980


<210>  2949
<211>  377
<212>  PRT
<213>  Homosapiens

<400>  2949

Met Val Thr Glu Met Asn Pro Asn Val Val Val Ile Ser Val Leu Ala 
1               5                   10                  15      


Ile Leu Ser Thr Leu Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile 
            20                  25                  30          


Leu Arg Lys Lys His Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr 
        35                  40                  45              


Phe Val Asn Phe Ala Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn 
    50                  55                  60                  


Trp Ser Lys Asn Gly Leu Lys Lys Arg Lys Leu Thr Asn Pro Val Gln 
65                  70                  75                  80  


Leu Asp Asp Phe Asp Ala Tyr Ile Lys Asp Met Ala Lys Asp Ser Asp 
                85                  90                  95      


Tyr Lys Phe Ser Leu Gln Phe Glu Glu Leu Lys Leu Ile Gly Leu Asp 
            100                 105                 110         


Ile Pro His Phe Ala Ala Asp Leu Pro Leu Asn Arg Cys Lys Asn Arg 
        115                 120                 125             


Tyr Thr Asn Ile Leu Pro Tyr Asp Phe Ser Arg Val Arg Leu Val Ser 
    130                 135                 140                 


Met Asn Glu Glu Glu Gly Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Pro 
145                 150                 155                 160 


Gly Tyr Asn Ser Pro Gln Glu Tyr Ile Ala Thr Gln Gly Pro Leu Pro 
                165                 170                 175     


Glu Thr Arg Asn Asp Phe Trp Lys Met Val Leu Gln Gln Lys Ser Gln 
            180                 185                 190         


Ile Ile Val Met Leu Thr Gln Cys Asn Glu Lys Arg Arg Val Lys Cys 
        195                 200                 205             


Asp His Tyr Trp Pro Phe Thr Glu Glu Pro Ile Ala Tyr Gly Asp Ile 
    210                 215                 220                 


Thr Val Glu Met Ile Ser Glu Glu Glu Gln Asp Asp Trp Ala Cys Arg 
225                 230                 235                 240 


His Phe Arg Ile Asn Tyr Ala Asp Glu Met Gln Asp Val Met His Phe 
                245                 250                 255     


Asn Tyr Thr Ala Trp Pro Asp His Gly Val Pro Thr Ala Asn Ala Ala 
            260                 265                 270         


Glu Ser Ile Leu Gln Phe Val His Met Val Arg Gln Gln Ala Thr Lys 
        275                 280                 285             


Ser Lys Gly Pro Met Ile Ile His Cys Ser Ala Gly Val Gly Arg Thr 
    290                 295                 300                 


Gly Thr Phe Ile Ala Leu Asp Arg Leu Leu Gln His Ile Arg Asp His 
305                 310                 315                 320 


Glu Phe Val Asp Ile Leu Gly Leu Val Ser Glu Met Arg Ser Tyr Arg 
                325                 330                 335     


Met Ser Met Val Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Gln Cys 
            340                 345                 350         


Val Gln Leu Met Trp Met Lys Lys Lys Gln Gln Phe Cys Ile Ser Asp 
        355                 360                 365             


Val Ile Tyr Glu Asn Val Ser Lys Ser 
    370                 375         


<210>  2950
<211>  4064
<212>  DNA
<213>  Homosapiens

<400>  2950
aagtaaaaaa atggaagggg gaaaaggcaa agtattctgc cttccaagtt agatagctat     60

ctttatgaaa ggacatattt caaaggcaat ataaagtctt tatggtgctc ttacctacct    120

atatttgaat tgggggatgc ttcacctgct tattagtgaa agaagaaaga atacacttag    180

taaattaaat tttttttaaa actttgtctt tgctcagaac cagctccacc caaatcactc    240

ttcgcagtga acaaaaccca gacttcagtg actttgctgt gggtggaaga gggagtagct    300

gatttctttg aagttttctg tcaacaagtt ggctccagtc agaaaaccaa acttcaggaa    360

ccagttgctg tttcttccca tgtcgtgacc atctccagcc ttcttcctgc cactgcctac    420

aattgtagtg tcaccagctt tagccatgac agccccagtg tccctacgtt catagccgtc    480

tcaacaatgg ttacagagat gaatcccaat gtggtagtga tctccgtgct ggccatcctt    540

agcacacttt taattggact gttgcttgtt accctcatta ttcttaggaa aaagcatctg    600

cagatggcta gggagtgtgg agctggtaca tttgtcaatt ttgcatcctt agagagggat    660

ggaaagcttc catacaactg gcgtaggagt atatttgctt tcttaaccct gctaccctca    720

tgtctttgga ctgattatct tttggcattt tatattaatc cttggagtaa aaatggttta    780

aagaagagga aactgacaaa cccggttcaa ctggatgact ttgatgccta tattaaggat    840

atggccaaag actctgacta taaattttct cttcagtttg aggagttgaa attgattgga    900

ctggatatcc cacactttgc tgcagatctt ccactgaatc gatgtaaaaa ccgttacaca    960

aacatcctac catatgactt cagccgtgtg agattagtct ccatgaatga agaggaaggt   1020

gcagactaca tcaatgccaa ctatattcct ggatacaact caccccagga gtatattgcc   1080

acccaggggc cactgcctga aaccagaaat gacttctgga agatggtcct gcaacaaaag   1140

tctcagatta ttgtcatgct cactcagtgt aatgagaaaa ggagggtgaa atgtgaccat   1200

tactggccat tcacggaaga acctatagcc tatggagaca tcactgtgga gatgatttca   1260

gaggaagagc aggacgactg ggcctgtaga cacttccgga tcaactatgc tgacgagatg   1320

caggatgtga tgcattttaa ctacactgca tggcctgatc atggtgtgcc cacagcaaat   1380

gctgcagaaa gtatcctgca gtttgtacac atggtccgac agcaagctac caagagcaaa   1440

ggtcccatga tcattcactg cagtgctggc gtgggacgga caggaacatt cattgccctg   1500

gacaggctct tgcagcacat tcgggatcat gagtttgttg acatcttagg gctggtgtca   1560

gaaatgaggt cataccggat gtctatggta cagacagagg agcagtacat ttttatccat   1620

cagtgtgtgc aactgatgtg gatgaagaag aagcagcagt tctgcatcag tgatgtcata   1680

tacgagaatg ttagcaagtc ctagttcaga atccggagca gtaagtggag aagagctctc   1740

cacgagtgtt cagtcttaga actattagag ggggatgtga tggatgggac aaaagacagc   1800

agtagccatt tgtattgact ctgacttcac atgagtattt cttcccagct cctggcctca   1860

catgggtggt cacagggaga aacaagtact gtagcagatc tttgagtttc aatgcacctt   1920

ggttggtgtt ggcaacaaac aggagcttct gcacatcatg atgactttac ctccattccc   1980

tctacccaga accctaaatt attctgttat tggatctgtg cctgtaatat caggatacta   2040

ccatccaaat ctatctagat atcttgtgca aatattttat tgattacaag ggctgtatac   2100

ggggttacaa aaagacatga gctggattgg acactcctaa aaccaaaaac aacagtgaca   2160

atagagtctc aggatagcag agtctgaaaa taccttggtc tcccccatta tgtgagccct   2220

tatttgagag cttcatgaag acacttgtaa catattcaac gtcctgtact ccagttttga   2280

ctacgagatc agattttgga ggtgtaagta atcttggctg aggtaacagt aatctgccca   2340

tttagttcag taaacagact gtagagtgtc tgactatact gggggaagag gagccaatga   2400

cagggtaggg agatgacagt ggtgcatgat gggagaatca tgaaagtctg ggaagcatat   2460

ggaccagtgg gaaggatagg attagcactg cacctctaca tccatcaaga gagacagagc   2520

gcacaatgga gcaggaagga taaaaaataa agaaagacag agacaaacaa atttgctggg   2580

agagggaaag acattcagac ccacagaaag gaggcagcac acagagaaag atgcacagat   2640

caacccacat ctgcatgggt tgtgagactg agcatagtga gagcagtggt ggagcaatag   2700

aagattgctg tgacaccagg ctgcttactg tctttctttg tctcattcac aggagaggac   2760

atgatgtgcg cccatcctcc cttgcttcca gattgtttta gtgggccctg atggtcattt   2820

ttctaaacag aggccctgct ttgtaatatg tggccaagga gataatttat ctcacagaag   2880

caccgggaag acttagcctt aaagagccta cagtgtcctt ttggactctt tcacttcggg   2940

acatttaata atggaccaaa ttcaacagaa caccaggaag gtcaagacgc tctccaaagg   3000

gcaggaagta cagcacttcc gaagagttta gttggccctt tgctggttgg gctgagtttt   3060

ttatttttaa gtgtttgttt ttcagtgcaa taatttttgt gtgtgtgtga ttcttatcag   3120

aaagttgaat tgttttctgc ctacaccgtt catcagcccc ataacccagg aaggaacagg   3180

cattgttagc atcagattat acctcattat taaaaggagg catggccaca catgaagaaa   3240

tggtcattct acttcaaaga aattgagcca gcactatctg tactccaaca ttaccggatc   3300

tggattgggg aggttggtca gggaagagag gggttctacc cacagatcaa ctgtgtaatc   3360

ttttactatt caagctataa ttcagcttca aagtagagta gaaaaaaaat tgtcttaact   3420

gttctagttc ttgatggttt tcttccttat taacagttgg tgtttcttcc ttggcccttt   3480

tggactaatg ttactgtcca agttctttct caagaaacca catctggttc agaagagtgt   3540

caagttggac tctttgaact ctgttgctgt ctgagcaatc gtggtgccta gactttgcat   3600

tccttgttct gttgacctgc atacatgtga gagctatttc tttaagaact atataggctg   3660

tgaaaacgca ctttctttcc cccaaagagc tgggaattta tgaagttatg gcaatgaact   3720

gcagcatgct gggacaatta tttgactact tttttttgta atattgtcaa atgtctctat   3780

ggattctgac agagatttct ttttgttttg ttattctttt ggttgtcagt ttcattttaa   3840

cgagtgtaac tagtaacatt ttattctttg gattttgtat aattacagta catgattgtg   3900

tattgtgaca tgaatgctgt caaaatgaca ttgatggcat tgtgaagcct gttactttgt   3960

gtcacttcct gataaataag aggtgatgac atggatatac aacagaaaac actttgagtt   4020

gaaagtaaac acaagctggc tgcttccctg tggcaactgt ggct                    4064


<210>  2951
<211>  405
<212>  PRT
<213>  Homosapiens

<400>  2951

Met Val Thr Glu Met Asn Pro Asn Val Val Val Ile Ser Val Leu Ala 
1               5                   10                  15      


Ile Leu Ser Thr Leu Leu Ile Gly Leu Leu Leu Val Thr Leu Ile Ile 
            20                  25                  30          


Leu Arg Lys Lys His Leu Gln Met Ala Arg Glu Cys Gly Ala Gly Thr 
        35                  40                  45              


Phe Val Asn Phe Ala Ser Leu Glu Arg Asp Gly Lys Leu Pro Tyr Asn 
    50                  55                  60                  


Trp Arg Arg Ser Ile Phe Ala Phe Leu Thr Leu Leu Pro Ser Cys Leu 
65                  70                  75                  80  


Trp Thr Asp Tyr Leu Leu Ala Phe Tyr Ile Asn Pro Trp Ser Lys Asn 
                85                  90                  95      


Gly Leu Lys Lys Arg Lys Leu Thr Asn Pro Val Gln Leu Asp Asp Phe 
            100                 105                 110         


Asp Ala Tyr Ile Lys Asp Met Ala Lys Asp Ser Asp Tyr Lys Phe Ser 
        115                 120                 125             


Leu Gln Phe Glu Glu Leu Lys Leu Ile Gly Leu Asp Ile Pro His Phe 
    130                 135                 140                 


Ala Ala Asp Leu Pro Leu Asn Arg Cys Lys Asn Arg Tyr Thr Asn Ile 
145                 150                 155                 160 


Leu Pro Tyr Asp Phe Ser Arg Val Arg Leu Val Ser Met Asn Glu Glu 
                165                 170                 175     


Glu Gly Ala Asp Tyr Ile Asn Ala Asn Tyr Ile Pro Gly Tyr Asn Ser 
            180                 185                 190         


Pro Gln Glu Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Arg Asn 
        195                 200                 205             


Asp Phe Trp Lys Met Val Leu Gln Gln Lys Ser Gln Ile Ile Val Met 
    210                 215                 220                 


Leu Thr Gln Cys Asn Glu Lys Arg Arg Val Lys Cys Asp His Tyr Trp 
225                 230                 235                 240 


Pro Phe Thr Glu Glu Pro Ile Ala Tyr Gly Asp Ile Thr Val Glu Met 
                245                 250                 255     


Ile Ser Glu Glu Glu Gln Asp Asp Trp Ala Cys Arg His Phe Arg Ile 
            260                 265                 270         


Asn Tyr Ala Asp Glu Met Gln Asp Val Met His Phe Asn Tyr Thr Ala 
        275                 280                 285             


Trp Pro Asp His Gly Val Pro Thr Ala Asn Ala Ala Glu Ser Ile Leu 
    290                 295                 300                 


Gln Phe Val His Met Val Arg Gln Gln Ala Thr Lys Ser Lys Gly Pro 
305                 310                 315                 320 


Met Ile Ile His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile 
                325                 330                 335     


Ala Leu Asp Arg Leu Leu Gln His Ile Arg Asp His Glu Phe Val Asp 
            340                 345                 350         


Ile Leu Gly Leu Val Ser Glu Met Arg Ser Tyr Arg Met Ser Met Val 
        355                 360                 365             


Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Gln Cys Val Gln Leu Met 
    370                 375                 380                 


Trp Met Lys Lys Lys Gln Gln Phe Cys Ile Ser Asp Val Ile Tyr Glu 
385                 390                 395                 400 


Asn Val Ser Lys Ser 
                405 


<210>  2952
<211>  4333
<212>  DNA
<213>  Homosapiens

<400>  2952
gagaaaatca attggtttag aaggtttgga ctcacttgac aggttcagtt ggagacgatc     60

ataggtggct gctgtgacaa agggaaattg tgcttttcca gcatgcttac tgaccctgat    120

ttacctcagg agtttgaaag gatgtcttcc aagcgaccag cctctccgta tggggaagca    180

gatggagagg tagccatggt gacaagcaga cagaaagtgg aagaagagga gagtgacggg    240

ctcccagcct ttcaccttcc cttgcatgtg agttttccca acaagcctca ctctgaggaa    300

tttcagccag tttctctgct gacgcaagag acttgtggcc ataggactcc cacttctcag    360

cacaatacaa tggaagttga tggcaataaa gttatgtctt catttgcccc acacaactca    420

tctacctcac ctcagaaggc agaagaaggt gggcgacaga gtggcgagtc cttgtctagt    480

acagccctgg gaactcctga acggcgcaag ggcagtttag ctgatgttgt tgacaccttg    540

aagcagagga aaatggaaga gctcatcaaa aacgagccgg aagaaacccc cagtattgaa    600

aaactactct caaaggactg gaaagacaag cttcttgcaa tgggatcggg gaactttggc    660

gaaataaaag ggactcccga gagcttagct gagaaagaaa ggcaactcat gggtatgatc    720

aaccagctga ccagcctccg agagcagctg ttggctgccc acgatgagca gaagaaacta    780

gctgcctctc agattgagaa acagcgtcag caaatggagc tggccaagca gcaacaagaa    840

caaattgcaa gacagcagca gcagcttcta cagcaacaac acaaaatcaa tttgctccag    900

caacagatcc aggttcaagg tcagctgccg ccattaatga ttcccgtatt ccctcctgat    960

caacggacac tggctgcagc tgcccagcaa ggattcctcc tccctccagg cttcagctat   1020

aaggctggat gtagtgaccc ttaccctgtt cagctgatcc caactaccat ggcagctgct   1080

gccgcagcaa caccaggctt aggcccactc caactgcagc agttatatgc tgcccagcta   1140

gctgcaatgc aggtatctcc aggagggaag ctgccaggca taccccaagg caaccttggt   1200

gctgctgtat ctcctaccag cattcacaca gacaagagca caaacagccc accacccaaa   1260

agcaaggatg aagtggcaca gccactgaac ctatcagcta aacccaagac ctctgatggc   1320

aaatcaccca catcacccac ctctccccat atgccagctc tgagaataaa cagtggggca   1380

ggccccctca aagcctctgt cccagcagcg ttagctagtc cttcagccag agttagcaca   1440

ataggttact taaatgacca tgatgctgtc accaaggcaa tccaagaagc tcggcaaatg   1500

aaggagcaac tccgacggga acaacaggtg cttgatggga aggtggctgt tgtgaatagt   1560

ctgggtctca ataactgccg aacagaaaag gaaaaaacaa cactggagag tctgactcag   1620

caactggcag ttaaacagaa tgaagaagga aaatttagcc atgcaatgat ggatttcaat   1680

ctgagtggag attctgatgg aagtgctgga gtctcagagt caagaattta tagggaatcc   1740

cgagggcgtg gtagcaatga accccacata aagcgtccaa tgaatgcctt catggtgtgg   1800

gctaaagatg aacggagaaa gatccttcaa gcctttcctg acatgcacaa ctccaacatc   1860

agcaagatat tgggatctcg ctggaaagct atgacaaacc tagagaaaca gccatattat   1920

gaggagcaag cccgtctcag caagcagcac ctggagaagt accctgacta taagtacaag   1980

cccaggccaa agcgcacctg cctggtggat ggcaaaaagc tgcgcattgg tgaatacaag   2040

gcaatcatgc gcaacaggcg gcaggaaatg cggcagtact tcaatgttgg gcaacaagca   2100

cagatcccca ttgccactgc tggtgttgtg taccctggag ccatcgccat ggctgggatg   2160

ccctcccctc acctgccctc ggagcactca agcgtgtcta gcagcccaga gcctgggatg   2220

cctgttatcc agagcactta cggtgtgaaa ggagaggagc cacatatcaa agaagagata   2280

caggccgagg acatcaatgg agaaatttat gatgagtacg acgaggaaga ggatgatcca   2340

gatgtagatt atgggagtga cagtgaaaac catattgcag gacaagccaa ctgataaggg   2400

tcaaaagatt gttgtgacct taggacttaa agaagcccta actggttcat ccttaccagt   2460

ggccaagcac attaactttc tcatacactg actgttactt taactgttag tcttaaatag   2520

ttgggacatc agctgactaa tagacctcag cctcaaaagg cttggaaaga aaaaacaaat   2580

acaacaagca aacaacaata tcaacaacaa gagattgaaa taagctatgg gtaaaataat   2640

gccagtaatt cagctgctac atccaagcac tgaagtctta cccgtcaact tttttttttt   2700

tttaaataaa ctttatggct gtttgttcta caatgttcta gaaattctca ctcaggtaca   2760

cagtgccaac aagtggcttg tgaatgtgtt ttgttgtttt gtgctacaat ttttaaaaag   2820

aaaaaagttt tgttttgttt tttggggttt ctgggttttt tccttttctt tttctttcct   2880

ttcatttttt ttctttgtaa tgcacctgac agaaaaaaaa gaaaaatgaa tttctcttta   2940

cttctctcca ccttctccat ctctctactt taaagatgga agtctgtgca tgaggggaaa   3000

gagggaaaaa gagcctgttt ttaacttcct tgctatccac cacaaaataa gcaattattt   3060

tctttagagg actttatcta ttgcacacca cactacatct ttgagcaagt gccaaatttg   3120

tactgaagtg ttgaccaagt tcattttttc tctttacttt ttccttttcc ttcttaagtt   3180

aggacagtgt taaatcttag acaatccctt gaaaaacctg aaataccagc agctggtgag   3240

atttgacttt tttttttaat ggaaactgta ggtgctgttc tcaggtgaaa agagagagag   3300

agagagagac ataagaaatt tagagaaaaa tattttctga tcttggattt ttgtgtgtat   3360

gtatgtatgt gattatggta ctaataatag gaataacgtt ggaccattgt gagttaaacc   3420

cacatctggg gatgaaatcc cacatcctcc caagtgactg gtctagaaat aatcttgacc   3480

ttgactttgc acttcaaatg acaacttaac caagtatagg gctcagaaat tatattttta   3540

aatgtctgat tattattgga tggatcaggt ggccctgtgt aatagaggtg tgcatgtata   3600

acatggaagc tactagcaaa ctgctcccag atgtcctttc tccctggtca gttggttcca   3660

ttaacgtttg ctacttagtg atttttgttt ttcctgttga tattttgagc aaaacaatca   3720

ttgttttcat tgaatatatt tggccatttt ttcagacaaa tagaattagc ttatttcttc   3780

aacattccat cctttcccga tcaggaaatg aaactgatga ttttataagg tatttttcac   3840

ccctccatga agtgaggtgg aggcctttag catttcagaa gtgtgggcca tatgtagttc   3900

atgccataaa aagtaggatt taattaaaag tcattgcagc ccaataaaat ggagcctggc   3960

tgcacccagg gatccttgcc actgctcttc ccttgctgtc agattaatcc actgaagtcc   4020

aactttggtt caagcagagt atttgcaaag agcaacaact gaatgtgatg ggactgctta   4080

tgtagatttt gccagccaaa tgccaaggca gttgtagggc ctgtacaaat aaatgcaaaa   4140

tcatttcaag tcaattgcca ttatttgtat tgaagtatca gatagatagt aaatactgca   4200

actagtagct tgatgtgcta tagttttcac tccagtcatc attttcctat ctcacccccc   4260

gaaacaccac cctaaagttg gatttttaca tataaataaa aaaagaatcc cttttaaaaa   4320

aaaaaaaaaa aaa                                                      4333


<210>  2953
<211>  763
<212>  PRT
<213>  Homosapiens

<400>  2953

Met Leu Thr Asp Pro Asp Leu Pro Gln Glu Phe Glu Arg Met Ser Ser 
1               5                   10                  15      


Lys Arg Pro Ala Ser Pro Tyr Gly Glu Ala Asp Gly Glu Val Ala Met 
            20                  25                  30          


Val Thr Ser Arg Gln Lys Val Glu Glu Glu Glu Ser Asp Gly Leu Pro 
        35                  40                  45              


Ala Phe His Leu Pro Leu His Val Ser Phe Pro Asn Lys Pro His Ser 
    50                  55                  60                  


Glu Glu Phe Gln Pro Val Ser Leu Leu Thr Gln Glu Thr Cys Gly His 
65                  70                  75                  80  


Arg Thr Pro Thr Ser Gln His Asn Thr Met Glu Val Asp Gly Asn Lys 
                85                  90                  95      


Val Met Ser Ser Phe Ala Pro His Asn Ser Ser Thr Ser Pro Gln Lys 
            100                 105                 110         


Ala Glu Glu Gly Gly Arg Gln Ser Gly Glu Ser Leu Ser Ser Thr Ala 
        115                 120                 125             


Leu Gly Thr Pro Glu Arg Arg Lys Gly Ser Leu Ala Asp Val Val Asp 
    130                 135                 140                 


Thr Leu Lys Gln Arg Lys Met Glu Glu Leu Ile Lys Asn Glu Pro Glu 
145                 150                 155                 160 


Glu Thr Pro Ser Ile Glu Lys Leu Leu Ser Lys Asp Trp Lys Asp Lys 
                165                 170                 175     


Leu Leu Ala Met Gly Ser Gly Asn Phe Gly Glu Ile Lys Gly Thr Pro 
            180                 185                 190         


Glu Ser Leu Ala Glu Lys Glu Arg Gln Leu Met Gly Met Ile Asn Gln 
        195                 200                 205             


Leu Thr Ser Leu Arg Glu Gln Leu Leu Ala Ala His Asp Glu Gln Lys 
    210                 215                 220                 


Lys Leu Ala Ala Ser Gln Ile Glu Lys Gln Arg Gln Gln Met Glu Leu 
225                 230                 235                 240 


Ala Lys Gln Gln Gln Glu Gln Ile Ala Arg Gln Gln Gln Gln Leu Leu 
                245                 250                 255     


Gln Gln Gln His Lys Ile Asn Leu Leu Gln Gln Gln Ile Gln Val Gln 
            260                 265                 270         


Gly Gln Leu Pro Pro Leu Met Ile Pro Val Phe Pro Pro Asp Gln Arg 
        275                 280                 285             


Thr Leu Ala Ala Ala Ala Gln Gln Gly Phe Leu Leu Pro Pro Gly Phe 
    290                 295                 300                 


Ser Tyr Lys Ala Gly Cys Ser Asp Pro Tyr Pro Val Gln Leu Ile Pro 
305                 310                 315                 320 


Thr Thr Met Ala Ala Ala Ala Ala Ala Thr Pro Gly Leu Gly Pro Leu 
                325                 330                 335     


Gln Leu Gln Gln Leu Tyr Ala Ala Gln Leu Ala Ala Met Gln Val Ser 
            340                 345                 350         


Pro Gly Gly Lys Leu Pro Gly Ile Pro Gln Gly Asn Leu Gly Ala Ala 
        355                 360                 365             


Val Ser Pro Thr Ser Ile His Thr Asp Lys Ser Thr Asn Ser Pro Pro 
    370                 375                 380                 


Pro Lys Ser Lys Asp Glu Val Ala Gln Pro Leu Asn Leu Ser Ala Lys 
385                 390                 395                 400 


Pro Lys Thr Ser Asp Gly Lys Ser Pro Thr Ser Pro Thr Ser Pro His 
                405                 410                 415     


Met Pro Ala Leu Arg Ile Asn Ser Gly Ala Gly Pro Leu Lys Ala Ser 
            420                 425                 430         


Val Pro Ala Ala Leu Ala Ser Pro Ser Ala Arg Val Ser Thr Ile Gly 
        435                 440                 445             


Tyr Leu Asn Asp His Asp Ala Val Thr Lys Ala Ile Gln Glu Ala Arg 
    450                 455                 460                 


Gln Met Lys Glu Gln Leu Arg Arg Glu Gln Gln Val Leu Asp Gly Lys 
465                 470                 475                 480 


Val Ala Val Val Asn Ser Leu Gly Leu Asn Asn Cys Arg Thr Glu Lys 
                485                 490                 495     


Glu Lys Thr Thr Leu Glu Ser Leu Thr Gln Gln Leu Ala Val Lys Gln 
            500                 505                 510         


Asn Glu Glu Gly Lys Phe Ser His Ala Met Met Asp Phe Asn Leu Ser 
        515                 520                 525             


Gly Asp Ser Asp Gly Ser Ala Gly Val Ser Glu Ser Arg Ile Tyr Arg 
    530                 535                 540                 


Glu Ser Arg Gly Arg Gly Ser Asn Glu Pro His Ile Lys Arg Pro Met 
545                 550                 555                 560 


Asn Ala Phe Met Val Trp Ala Lys Asp Glu Arg Arg Lys Ile Leu Gln 
                565                 570                 575     


Ala Phe Pro Asp Met His Asn Ser Asn Ile Ser Lys Ile Leu Gly Ser 
            580                 585                 590         


Arg Trp Lys Ala Met Thr Asn Leu Glu Lys Gln Pro Tyr Tyr Glu Glu 
        595                 600                 605             


Gln Ala Arg Leu Ser Lys Gln His Leu Glu Lys Tyr Pro Asp Tyr Lys 
    610                 615                 620                 


Tyr Lys Pro Arg Pro Lys Arg Thr Cys Leu Val Asp Gly Lys Lys Leu 
625                 630                 635                 640 


Arg Ile Gly Glu Tyr Lys Ala Ile Met Arg Asn Arg Arg Gln Glu Met 
                645                 650                 655     


Arg Gln Tyr Phe Asn Val Gly Gln Gln Ala Gln Ile Pro Ile Ala Thr 
            660                 665                 670         


Ala Gly Val Val Tyr Pro Gly Ala Ile Ala Met Ala Gly Met Pro Ser 
        675                 680                 685             


Pro His Leu Pro Ser Glu His Ser Ser Val Ser Ser Ser Pro Glu Pro 
    690                 695                 700                 


Gly Met Pro Val Ile Gln Ser Thr Tyr Gly Val Lys Gly Glu Glu Pro 
705                 710                 715                 720 


His Ile Lys Glu Glu Ile Gln Ala Glu Asp Ile Asn Gly Glu Ile Tyr 
                725                 730                 735     


Asp Glu Tyr Asp Glu Glu Glu Asp Asp Pro Asp Val Asp Tyr Gly Ser 
            740                 745                 750         


Asp Ser Glu Asn His Ile Ala Gly Gln Ala Asn 
        755                 760             


<210>  2954
<211>  4563
<212>  DNA
<213>  Homosapiens

<400>  2954
gtgaaaaagg cgagccacca aaacccatct ccagtctcct cccgggggcc cccagcccgc     60

ctctgtgcca ctttgcatcc cacgccggag gaggcattaa cgagaccggg taaggctttt    120

taaacggtcc aaggtgtaga gccatacttc aggaggatcc tcagaagttt tggacaagcc    180

tccccaaatg tggcaggtgc tgtgctggcc attggtgacc caaagatgat gaaaaatatg    240

ttcctgccca caaggagtta gcgacctact gggctttcct cttgctgatg acatgattcc    300

tgtttgaatc tgttgacaag attctgaaag ctgaacagag aattctggca ctgcactggg    360

taggaaaaag gatgtcttcc aagcgaccag cctctccgta tggggaagca gatggagagg    420

tagccatggt gacaagcaga cagaaagtgg aagaagagga gagtgacggg ctcccagcct    480

ttcaccttcc cttgcatgtg agttttccca acaagcctca ctctgaggaa tttcagccag    540

tttctctgct gacgcaagag acttgtggcc ataggactcc cacttctcag cacaatacaa    600

tggaagttga tggcaataaa gttatgtctt catttgcccc acacaactca tctacctcac    660

ctcagaaggc agaagaaggt gggcgacaga gtggcgagtc cttgtctagt acagccctgg    720

gaactcctga acggcgcaag ggcagtttag ctgatgttgt tgacaccttg aagcagagga    780

aaatggaaga gctcatcaaa aacgagccgg aagaaacccc cagtattgaa aaactactct    840

caaaggactg gaaagacaag cttcttgcaa tgggatcggg gaactttggc gaaataaaag    900

ggactcccga gagcttagct gagaaagaaa ggcaactcat gggtatgatc aaccagctga    960

ccagcctccg agagcagctg ttggctgccc acgatgagca gaagaaacta gctgcctctc   1020

agattgagaa acagcgtcag caaatggagc tggccaagca gcaacaagaa caaattgcaa   1080

gacagcagca gcagcttcta cagcaacaac acaaaatcaa tttgctccag caacagatcc   1140

aggttcaagg tcagctgccg ccattaatga ttcccgtatt ccctcctgat caacggacac   1200

tggctgcagc tgcccagcaa ggattcctcc tccctccagg cttcagctat aaggctggat   1260

gtagtgaccc ttaccctgtt cagctgatcc caactaccat ggcagctgct gccgcagcaa   1320

caccaggctt aggcccactc caactgcagc agttatatgc tgcccagcta gctgcaatgc   1380

aggtatctcc aggagggaag ctgccaggca taccccaagg caaccttggt gctgctgtat   1440

ctcctaccag cattcacaca gacaagagca caaacagccc accacccaaa agcaaggatg   1500

aagtggcaca gccactgaac ctatcagcta aacccaagac ctctgatggc aaatcaccca   1560

catcacccac ctctccccat atgccagctc tgagaataaa cagtggggca ggccccctca   1620

aagcctctgt cccagcagcg ttagctagtc cttcagccag agttagcaca ataggttact   1680

taaatgacca tgatgctgtc accaaggcaa tccaagaagc tcggcaaatg aaggagcaac   1740

tccgacggga acaacaggtg cttgatggga aggtggctgt tgtgaatagt ctgggtctca   1800

ataactgccg aacagaaaag gaaaaaacaa cactggagag tctgactcag caactggcag   1860

ttaaacagaa tgaagaagga aaatttagcc atgcaatgat ggatttcaat ctgagtggag   1920

attctgatgg aagtgctgga gtctcagagt caagaattta tagggaatcc cgagggcgtg   1980

gtagcaatga accccacata aagcgtccaa tgaatgcctt catggtgtgg gctaaagatg   2040

aacggagaaa gatccttcaa gcctttcctg acatgcacaa ctccaacatc agcaagatat   2100

tgggatctcg ctggaaagct atgacaaacc tagagaaaca gccatattat gaggagcaag   2160

cccgtctcag caagcagcac ctggagaagt accctgacta taagtacaag cccaggccaa   2220

agcgcacctg cctggtggat ggcaaaaagc tgcgcattgg tgaatacaag gcaatcatgc   2280

gcaacaggcg gcaggaaatg cggcagtact tcaatgttgg gcaacaagca cagatcccca   2340

ttgccactgc tggtgttgtg taccctggag ccatcgccat ggctgggatg ccctcccctc   2400

acctgccctc ggagcactca agcgtgtcta gcagcccaga gcctgggatg cctgttatcc   2460

agagcactta cggtgtgaaa ggagaggagc cacatatcaa agaagagata caggccgagg   2520

acatcaatgg agaaatttat gatgagtacg acgaggaaga ggatgatcca gatgtagatt   2580

atgggagtga cagtgaaaac catattgcag gacaagccaa ctgataaggg tcaaaagatt   2640

gttgtgacct taggacttaa agaagcccta actggttcat ccttaccagt ggccaagcac   2700

attaactttc tcatacactg actgttactt taactgttag tcttaaatag ttgggacatc   2760

agctgactaa tagacctcag cctcaaaagg cttggaaaga aaaaacaaat acaacaagca   2820

aacaacaata tcaacaacaa gagattgaaa taagctatgg gtaaaataat gccagtaatt   2880

cagctgctac atccaagcac tgaagtctta cccgtcaact tttttttttt tttaaataaa   2940

ctttatggct gtttgttcta caatgttcta gaaattctca ctcaggtaca cagtgccaac   3000

aagtggcttg tgaatgtgtt ttgttgtttt gtgctacaat ttttaaaaag aaaaaagttt   3060

tgttttgttt tttggggttt ctgggttttt tccttttctt tttctttcct ttcatttttt   3120

ttctttgtaa tgcacctgac agaaaaaaaa gaaaaatgaa tttctcttta cttctctcca   3180

ccttctccat ctctctactt taaagatgga agtctgtgca tgaggggaaa gagggaaaaa   3240

gagcctgttt ttaacttcct tgctatccac cacaaaataa gcaattattt tctttagagg   3300

actttatcta ttgcacacca cactacatct ttgagcaagt gccaaatttg tactgaagtg   3360

ttgaccaagt tcattttttc tctttacttt ttccttttcc ttcttaagtt aggacagtgt   3420

taaatcttag acaatccctt gaaaaacctg aaataccagc agctggtgag atttgacttt   3480

tttttttaat ggaaactgta ggtgctgttc tcaggtgaaa agagagagag agagagagac   3540

ataagaaatt tagagaaaaa tattttctga tcttggattt ttgtgtgtat gtatgtatgt   3600

gattatggta ctaataatag gaataacgtt ggaccattgt gagttaaacc cacatctggg   3660

gatgaaatcc cacatcctcc caagtgactg gtctagaaat aatcttgacc ttgactttgc   3720

acttcaaatg acaacttaac caagtatagg gctcagaaat tatattttta aatgtctgat   3780

tattattgga tggatcaggt ggccctgtgt aatagaggtg tgcatgtata acatggaagc   3840

tactagcaaa ctgctcccag atgtcctttc tccctggtca gttggttcca ttaacgtttg   3900

ctacttagtg atttttgttt ttcctgttga tattttgagc aaaacaatca ttgttttcat   3960

tgaatatatt tggccatttt ttcagacaaa tagaattagc ttatttcttc aacattccat   4020

cctttcccga tcaggaaatg aaactgatga ttttataagg tatttttcac ccctccatga   4080

agtgaggtgg aggcctttag catttcagaa gtgtgggcca tatgtagttc atgccataaa   4140

aagtaggatt taattaaaag tcattgcagc ccaataaaat ggagcctggc tgcacccagg   4200

gatccttgcc actgctcttc ccttgctgtc agattaatcc actgaagtcc aactttggtt   4260

caagcagagt atttgcaaag agcaacaact gaatgtgatg ggactgctta tgtagatttt   4320

gccagccaaa tgccaaggca gttgtagggc ctgtacaaat aaatgcaaaa tcatttcaag   4380

tcaattgcca ttatttgtat tgaagtatca gatagatagt aaatactgca actagtagct   4440

tgatgtgcta tagttttcac tccagtcatc attttcctat ctcacccccc gaaacaccac   4500

cctaaagttg gatttttaca tataaataaa aaaagaatcc cttttaaaaa aaaaaaaaaa   4560

aaa                                                                 4563


<210>  2955
<211>  750
<212>  PRT
<213>  Homosapiens

<400>  2955

Met Ser Ser Lys Arg Pro Ala Ser Pro Tyr Gly Glu Ala Asp Gly Glu 
1               5                   10                  15      


Val Ala Met Val Thr Ser Arg Gln Lys Val Glu Glu Glu Glu Ser Asp 
            20                  25                  30          


Gly Leu Pro Ala Phe His Leu Pro Leu His Val Ser Phe Pro Asn Lys 
        35                  40                  45              


Pro His Ser Glu Glu Phe Gln Pro Val Ser Leu Leu Thr Gln Glu Thr 
    50                  55                  60                  


Cys Gly His Arg Thr Pro Thr Ser Gln His Asn Thr Met Glu Val Asp 
65                  70                  75                  80  


Gly Asn Lys Val Met Ser Ser Phe Ala Pro His Asn Ser Ser Thr Ser 
                85                  90                  95      


Pro Gln Lys Ala Glu Glu Gly Gly Arg Gln Ser Gly Glu Ser Leu Ser 
            100                 105                 110         


Ser Thr Ala Leu Gly Thr Pro Glu Arg Arg Lys Gly Ser Leu Ala Asp 
        115                 120                 125             


Val Val Asp Thr Leu Lys Gln Arg Lys Met Glu Glu Leu Ile Lys Asn 
    130                 135                 140                 


Glu Pro Glu Glu Thr Pro Ser Ile Glu Lys Leu Leu Ser Lys Asp Trp 
145                 150                 155                 160 


Lys Asp Lys Leu Leu Ala Met Gly Ser Gly Asn Phe Gly Glu Ile Lys 
                165                 170                 175     


Gly Thr Pro Glu Ser Leu Ala Glu Lys Glu Arg Gln Leu Met Gly Met 
            180                 185                 190         


Ile Asn Gln Leu Thr Ser Leu Arg Glu Gln Leu Leu Ala Ala His Asp 
        195                 200                 205             


Glu Gln Lys Lys Leu Ala Ala Ser Gln Ile Glu Lys Gln Arg Gln Gln 
    210                 215                 220                 


Met Glu Leu Ala Lys Gln Gln Gln Glu Gln Ile Ala Arg Gln Gln Gln 
225                 230                 235                 240 


Gln Leu Leu Gln Gln Gln His Lys Ile Asn Leu Leu Gln Gln Gln Ile 
                245                 250                 255     


Gln Val Gln Gly Gln Leu Pro Pro Leu Met Ile Pro Val Phe Pro Pro 
            260                 265                 270         


Asp Gln Arg Thr Leu Ala Ala Ala Ala Gln Gln Gly Phe Leu Leu Pro 
        275                 280                 285             


Pro Gly Phe Ser Tyr Lys Ala Gly Cys Ser Asp Pro Tyr Pro Val Gln 
    290                 295                 300                 


Leu Ile Pro Thr Thr Met Ala Ala Ala Ala Ala Ala Thr Pro Gly Leu 
305                 310                 315                 320 


Gly Pro Leu Gln Leu Gln Gln Leu Tyr Ala Ala Gln Leu Ala Ala Met 
                325                 330                 335     


Gln Val Ser Pro Gly Gly Lys Leu Pro Gly Ile Pro Gln Gly Asn Leu 
            340                 345                 350         


Gly Ala Ala Val Ser Pro Thr Ser Ile His Thr Asp Lys Ser Thr Asn 
        355                 360                 365             


Ser Pro Pro Pro Lys Ser Lys Asp Glu Val Ala Gln Pro Leu Asn Leu 
    370                 375                 380                 


Ser Ala Lys Pro Lys Thr Ser Asp Gly Lys Ser Pro Thr Ser Pro Thr 
385                 390                 395                 400 


Ser Pro His Met Pro Ala Leu Arg Ile Asn Ser Gly Ala Gly Pro Leu 
                405                 410                 415     


Lys Ala Ser Val Pro Ala Ala Leu Ala Ser Pro Ser Ala Arg Val Ser 
            420                 425                 430         


Thr Ile Gly Tyr Leu Asn Asp His Asp Ala Val Thr Lys Ala Ile Gln 
        435                 440                 445             


Glu Ala Arg Gln Met Lys Glu Gln Leu Arg Arg Glu Gln Gln Val Leu 
    450                 455                 460                 


Asp Gly Lys Val Ala Val Val Asn Ser Leu Gly Leu Asn Asn Cys Arg 
465                 470                 475                 480 


Thr Glu Lys Glu Lys Thr Thr Leu Glu Ser Leu Thr Gln Gln Leu Ala 
                485                 490                 495     


Val Lys Gln Asn Glu Glu Gly Lys Phe Ser His Ala Met Met Asp Phe 
            500                 505                 510         


Asn Leu Ser Gly Asp Ser Asp Gly Ser Ala Gly Val Ser Glu Ser Arg 
        515                 520                 525             


Ile Tyr Arg Glu Ser Arg Gly Arg Gly Ser Asn Glu Pro His Ile Lys 
    530                 535                 540                 


Arg Pro Met Asn Ala Phe Met Val Trp Ala Lys Asp Glu Arg Arg Lys 
545                 550                 555                 560 


Ile Leu Gln Ala Phe Pro Asp Met His Asn Ser Asn Ile Ser Lys Ile 
                565                 570                 575     


Leu Gly Ser Arg Trp Lys Ala Met Thr Asn Leu Glu Lys Gln Pro Tyr 
            580                 585                 590         


Tyr Glu Glu Gln Ala Arg Leu Ser Lys Gln His Leu Glu Lys Tyr Pro 
        595                 600                 605             


Asp Tyr Lys Tyr Lys Pro Arg Pro Lys Arg Thr Cys Leu Val Asp Gly 
    610                 615                 620                 


Lys Lys Leu Arg Ile Gly Glu Tyr Lys Ala Ile Met Arg Asn Arg Arg 
625                 630                 635                 640 


Gln Glu Met Arg Gln Tyr Phe Asn Val Gly Gln Gln Ala Gln Ile Pro 
                645                 650                 655     


Ile Ala Thr Ala Gly Val Val Tyr Pro Gly Ala Ile Ala Met Ala Gly 
            660                 665                 670         


Met Pro Ser Pro His Leu Pro Ser Glu His Ser Ser Val Ser Ser Ser 
        675                 680                 685             


Pro Glu Pro Gly Met Pro Val Ile Gln Ser Thr Tyr Gly Val Lys Gly 
    690                 695                 700                 


Glu Glu Pro His Ile Lys Glu Glu Ile Gln Ala Glu Asp Ile Asn Gly 
705                 710                 715                 720 


Glu Ile Tyr Asp Glu Tyr Asp Glu Glu Glu Asp Asp Pro Asp Val Asp 
                725                 730                 735     


Tyr Gly Ser Asp Ser Glu Asn His Ile Ala Gly Gln Ala Asn 
            740                 745                 750 


<210>  2956
<211>  3095
<212>  DNA
<213>  Homosapiens

<400>  2956
atttgtgcca taggagctgt gcatgcatga tgaagtggca cagccactga acctatcagc     60

taaacccaag acctctgatg gcaaatcacc cacatcaccc acctctcccc atatgccagc    120

tctgagaata aacagtgggg caggccccct caaagcctct gtcccagcag cgttagctag    180

tccttcagcc agagttagca caataggtta cttaaatgac catgatgctg tcaccaaggc    240

aatccaagaa gctcggcaaa tgaaggagca actccgacgg gaacaacagg tgcttgatgg    300

gaaggtggct gttgtgaata gtctgggtct caataactgc cgaacagaaa aggaaaaaac    360

aacactggag agtctgactc agcaactggc agttaaacag aatgaagaag gaaaatttag    420

ccatgcaatg atggatttca atctgagtgg agattctgat ggaagtgctg gagtctcaga    480

gtcaagaatt tatagggaat cccgagggcg tggtagcaat gaaccccaca taaagcgtcc    540

aatgaatgcc ttcatggtgt gggctaaaga tgaacggaga aagatccttc aagcctttcc    600

tgacatgcac aactccaaca tcagcaagat attgggatct cgctggaaag ctatgacaaa    660

cctagagaaa cagccatatt atgaggagca agcccgtctc agcaagcagc acctggagaa    720

gtaccctgac tataagtaca agcccaggcc aaagcgcacc tgcctggtgg atggcaaaaa    780

gctgcgcatt ggtgaataca aggcaatcat gcgcaacagg cggcaggaaa tgcggcagta    840

cttcaatgtt gggcaacaag cacagatccc cattgccact gctggtgttg tgtaccctgg    900

agccatcgcc atggctggga tgccctcccc tcacctgccc tcggagcact caagcgtgtc    960

tagcagccca gagcctggga tgcctgttat ccagagcact tacggtgtga aaggagagga   1020

gccacatatc aaagaagaga tacaggccga ggacatcaat ggagaaattt atgatgagta   1080

cgacgaggaa gaggatgatc cagatgtaga ttatgggagt gacagtgaaa accatattgc   1140

aggacaagcc aactgataag ggtcaaaaga ttgttgtgac cttaggactt aaagaagccc   1200

taactggttc atccttacca gtggccaagc acattaactt tctcatacac tgactgttac   1260

tttaactgtt agtcttaaat agttgggaca tcagctgact aatagacctc agcctcaaaa   1320

ggcttggaaa gaaaaaacaa atacaacaag caaacaacaa tatcaacaac aagagattga   1380

aataagctat gggtaaaata atgccagtaa ttcagctgct acatccaagc actgaagtct   1440

tacccgtcaa cttttttttt tttttaaata aactttatgg ctgtttgttc tacaatgttc   1500

tagaaattct cactcaggta cacagtgcca acaagtggct tgtgaatgtg ttttgttgtt   1560

ttgtgctaca atttttaaaa agaaaaaagt tttgttttgt tttttggggt ttctgggttt   1620

tttccttttc tttttctttc ctttcatttt ttttctttgt aatgcacctg acagaaaaaa   1680

aagaaaaatg aatttctctt tacttctctc caccttctcc atctctctac tttaaagatg   1740

gaagtctgtg catgagggga aagagggaaa aagagcctgt ttttaacttc cttgctatcc   1800

accacaaaat aagcaattat tttctttaga ggactttatc tattgcacac cacactacat   1860

ctttgagcaa gtgccaaatt tgtactgaag tgttgaccaa gttcattttt tctctttact   1920

ttttcctttt ccttcttaag ttaggacagt gttaaatctt agacaatccc ttgaaaaacc   1980

tgaaatacca gcagctggtg agatttgact ttttttttta atggaaactg taggtgctgt   2040

tctcaggtga aaagagagag agagagagag acataagaaa tttagagaaa aatattttct   2100

gatcttggat ttttgtgtgt atgtatgtat gtgattatgg tactaataat aggaataacg   2160

ttggaccatt gtgagttaaa cccacatctg gggatgaaat cccacatcct cccaagtgac   2220

tggtctagaa ataatcttga ccttgacttt gcacttcaaa tgacaactta accaagtata   2280

gggctcagaa attatatttt taaatgtctg attattattg gatggatcag gtggccctgt   2340

gtaatagagg tgtgcatgta taacatggaa gctactagca aactgctccc agatgtcctt   2400

tctccctggt cagttggttc cattaacgtt tgctacttag tgatttttgt ttttcctgtt   2460

gatattttga gcaaaacaat cattgttttc attgaatata tttggccatt ttttcagaca   2520

aatagaatta gcttatttct tcaacattcc atcctttccc gatcaggaaa tgaaactgat   2580

gattttataa ggtatttttc acccctccat gaagtgaggt ggaggccttt agcatttcag   2640

aagtgtgggc catatgtagt tcatgccata aaaagtagga tttaattaaa agtcattgca   2700

gcccaataaa atggagcctg gctgcaccca gggatccttg ccactgctct tcccttgctg   2760

tcagattaat ccactgaagt ccaactttgg ttcaagcaga gtatttgcaa agagcaacaa   2820

ctgaatgtga tgggactgct tatgtagatt ttgccagcca aatgccaagg cagttgtagg   2880

gcctgtacaa ataaatgcaa aatcatttca agtcaattgc cattatttgt attgaagtat   2940

cagatagata gtaaatactg caactagtag cttgatgtgc tatagttttc actccagtca   3000

tcattttcct atctcacccc ccgaaacacc accctaaagt tggattttta catataaata   3060

aaaaaagaat cccttttaaa aaaaaaaaaa aaaaa                              3095


<210>  2957
<211>  377
<212>  PRT
<213>  Homosapiens

<400>  2957

Met His Asp Glu Val Ala Gln Pro Leu Asn Leu Ser Ala Lys Pro Lys 
1               5                   10                  15      


Thr Ser Asp Gly Lys Ser Pro Thr Ser Pro Thr Ser Pro His Met Pro 
            20                  25                  30          


Ala Leu Arg Ile Asn Ser Gly Ala Gly Pro Leu Lys Ala Ser Val Pro 
        35                  40                  45              


Ala Ala Leu Ala Ser Pro Ser Ala Arg Val Ser Thr Ile Gly Tyr Leu 
    50                  55                  60                  


Asn Asp His Asp Ala Val Thr Lys Ala Ile Gln Glu Ala Arg Gln Met 
65                  70                  75                  80  


Lys Glu Gln Leu Arg Arg Glu Gln Gln Val Leu Asp Gly Lys Val Ala 
                85                  90                  95      


Val Val Asn Ser Leu Gly Leu Asn Asn Cys Arg Thr Glu Lys Glu Lys 
            100                 105                 110         


Thr Thr Leu Glu Ser Leu Thr Gln Gln Leu Ala Val Lys Gln Asn Glu 
        115                 120                 125             


Glu Gly Lys Phe Ser His Ala Met Met Asp Phe Asn Leu Ser Gly Asp 
    130                 135                 140                 


Ser Asp Gly Ser Ala Gly Val Ser Glu Ser Arg Ile Tyr Arg Glu Ser 
145                 150                 155                 160 


Arg Gly Arg Gly Ser Asn Glu Pro His Ile Lys Arg Pro Met Asn Ala 
                165                 170                 175     


Phe Met Val Trp Ala Lys Asp Glu Arg Arg Lys Ile Leu Gln Ala Phe 
            180                 185                 190         


Pro Asp Met His Asn Ser Asn Ile Ser Lys Ile Leu Gly Ser Arg Trp 
        195                 200                 205             


Lys Ala Met Thr Asn Leu Glu Lys Gln Pro Tyr Tyr Glu Glu Gln Ala 
    210                 215                 220                 


Arg Leu Ser Lys Gln His Leu Glu Lys Tyr Pro Asp Tyr Lys Tyr Lys 
225                 230                 235                 240 


Pro Arg Pro Lys Arg Thr Cys Leu Val Asp Gly Lys Lys Leu Arg Ile 
                245                 250                 255     


Gly Glu Tyr Lys Ala Ile Met Arg Asn Arg Arg Gln Glu Met Arg Gln 
            260                 265                 270         


Tyr Phe Asn Val Gly Gln Gln Ala Gln Ile Pro Ile Ala Thr Ala Gly 
        275                 280                 285             


Val Val Tyr Pro Gly Ala Ile Ala Met Ala Gly Met Pro Ser Pro His 
    290                 295                 300                 


Leu Pro Ser Glu His Ser Ser Val Ser Ser Ser Pro Glu Pro Gly Met 
305                 310                 315                 320 


Pro Val Ile Gln Ser Thr Tyr Gly Val Lys Gly Glu Glu Pro His Ile 
                325                 330                 335     


Lys Glu Glu Ile Gln Ala Glu Asp Ile Asn Gly Glu Ile Tyr Asp Glu 
            340                 345                 350         


Tyr Asp Glu Glu Glu Asp Asp Pro Asp Val Asp Tyr Gly Ser Asp Ser 
        355                 360                 365             


Glu Asn His Ile Ala Gly Gln Ala Asn 
    370                 375         


<210>  2958
<211>  3476
<212>  DNA
<213>  Homosapiens

<400>  2958
atccccgcct gacgggagct agccctcagt ccgcccgagc tgtggttgtg ggcgccggac     60

aagtccaagg cgcctcctcc caatatggac agccgctaca acagcactgc gggcatcggg    120

gacttgaacc agctgagcgc tgccatcccg gccacgcggg tggaggtgtc cgtgtcctgc    180

agaaatcttc ttgacagaga cacattttct aaatctgatc caatttgtgt cttatatgta    240

caaggagttg gaaataaaga atggagagag tttggaagaa ctgaagtaat tgataatact    300

ttaaatcctg attttgtaag aaagtttatt ctggactact tttttgaaga aagagagaat    360

cttcgttttg acttgtatga tgttgattca aagagcccca acttatccaa acatgacttt    420

ctgggacaag tgttttgtac attgggagag atcgttggtt cacagggaag tcgcctggaa    480

aaaccaatag taggaattcc agggaagaaa tgtggtacaa tcatacttac agcagaggaa    540

ttaaactgtt gcagggatgc cgttttgatg caattttgtg cgaacaaatt ggacaagaag    600

gacttctttg gaaaatcaga tcctttcctt gtattttatc gaagtaatga agatggcagt    660

tttacaattt gtcacaagac agaagttgtc aaaaacactc taaatccagt atggcaagca    720

ttcaagatct cagtcagagc attatgtaat ggagactatg acagaacaat caaagtagag    780

gtgtatgact gggaccgaga tggaagtcat gatttcattg gagaatttac aacaagctat    840

agggaacttt ctagagggca gtcacaattc aacgtatatg aggtggtgaa tcccaaaaag    900

aaaggaaaaa agaaaaaata tactaattct ggaacagtaa ctttactctc tttcttggta    960

gaaacagaag tttcattcct tgactacatt aagggaggga cgcaaatcaa tttcacagtg   1020

gctattgatt ttacagcatc aaacggcaac cctgctcagc ccacttccct ccactacatg   1080

aatccttacc aactgaatgc ctatggtatg gcactaaaag cagtgggaga aattgttcaa   1140

gattatgaca gtgataaaat gtttccagct ctaggatttg gtgcaaaact gcctccagat   1200

ggaaggatat ctcacgaatt tgctttgaat gggaatcctc aaaaccccta ctgtgatggc   1260

attgaggggg tcatggaggc ttattacagg agtctgaaat ctgtacaact atatgggccc   1320

accaactttg ctcctgtaat taatcatgta gcaagatatg cttcttctgt aaaggatggc   1380

tcccagtatt ttgtgcttct gattgttaca gatggtgtta tctcagatat ggcccagact   1440

aaggagtcca tagttaatgc ctcaaaactt ccaatgtcaa taattatagt aggtgttgga   1500

ccagcagaat ttgatgcaat ggtcgaattg gatggagatg atgtaagagt ctcctctaga   1560

ggaaaatatg ctgaaagaga cattgtgcag tttgtgccat tcagggatta tattgacaga   1620

agtggaaacc acatactgag catggctaga ttggctaaag atgtcctagc tgagatccct   1680

gagcagtttc tctcctatat gagagcccga ggaatcaagc catcacctgc gcctccccca   1740

tacaccccac ctacacatgt gttacagact caaatatgac tgtgctctga aatgctaatg   1800

tcaactacaa atcaaaagtg ctgagttaat gctttgtgcc tggtgctctg taatgaacca   1860

ggcaatgaga tagttttctc agtttggttt cagcagttaa tgtgctttct tggatccaaa   1920

tttaaatatc ttcctaaacc aaaactgtaa atatggttgt tgcatgagca acagaaaaaa   1980

ttgtttaaat gcttgaagca aagtatggat gtcttctcta aatctttctt tctttttttt   2040

tttaacagaa acagctaatt tccaatgtat tgttgggaaa aagcacaaac tgtgttttta   2100

actcaaatat tgtcttcgac tgctatgtgt ataggaaagc agtctctgta tcaatgttta   2160

catgttacta ctttttaaat ttcaatactt ttataactgt tcttaaaaat aagagtttta   2220

aatactgaat cctttgtctt ctaaattgca atagctataa tcacaagagc aatatctctt   2280

tgaatgactg tctggacaaa cacaattgca aataagggaa gggaaaaatg cttttctatt   2340

tttcagtaac tggattgtct taagaaacta catctgctta ataaacaatt tctcagcaat   2400

gtttgctggg tatgggagtt taagcccggc agatgtgtct cctggttgaa catgcatttt   2460

tcatggagtt tgggttctaa atttagactg cagttggttt gtattttgta acactaagta   2520

gaaattataa aaagtcaaac attgtgatct ataaatgcac agaaaatact ttgtaaaaag   2580

tagcatcctt atataataat gctatttaga aagactgaaa ccaagactat ttaactgtga   2640

actatgtagc agatgtttta aactttttat tccattatat cttgtctaga tattttaatt   2700

caaagggata ctggctctct tgatcggaat ttcttgttat caccattcca cgttgccaca   2760

caaggtgcac aggctggaag tcttttgtga aattcccagt taaatatata caactatgtg   2820

acttagtgca caacacattt gtgaaataac ctactcctat atactgacct gcctgtccac   2880

gaataattgt aaagggtttt tgcatgtaca gtttttacaa gaattacagt tttgtgaagt   2940

tgtgtctaaa ttaaagcatt tctttagaac aaatggcctt aaattctcac ggaattcctg   3000

gaaatgattg tgaattgcct tcaaataata gaaaagtgta tttatttgtg tgtgtgtgtg   3060

tgtcaaaaat gtaactgctt tataatattt tttccttacc tatatattct atttaatact   3120

tggtttattt ctactgtaca ttgttttctt tgtcccaagt tgacctaggg tgacttttat   3180

aagcatgaaa ctattttact ggaaagaaaa atatatacat ccacatatct aacagtatca   3240

atgttatata actatgtaat aattgttgat ttttaattat gtattaaaat ctttaaatca   3300

taactatttg ctttgtacgt ttcatgtatg aatgacaata gtttgatgat ttcctttact   3360

gatcttaaat atttatgcca ctacagtgta ttacctacag atttttaaat ttagctttat   3420

ttatcaaccc aaaaaacaaa taaataagat caatattctt taaaaaaaaa aaaaaa       3476


<210>  2959
<211>  564
<212>  PRT
<213>  Homosapiens

<400>  2959

Met Asp Ser Arg Tyr Asn Ser Thr Ala Gly Ile Gly Asp Leu Asn Gln 
1               5                   10                  15      


Leu Ser Ala Ala Ile Pro Ala Thr Arg Val Glu Val Ser Val Ser Cys 
            20                  25                  30          


Arg Asn Leu Leu Asp Arg Asp Thr Phe Ser Lys Ser Asp Pro Ile Cys 
        35                  40                  45              


Val Leu Tyr Val Gln Gly Val Gly Asn Lys Glu Trp Arg Glu Phe Gly 
    50                  55                  60                  


Arg Thr Glu Val Ile Asp Asn Thr Leu Asn Pro Asp Phe Val Arg Lys 
65                  70                  75                  80  


Phe Ile Leu Asp Tyr Phe Phe Glu Glu Arg Glu Asn Leu Arg Phe Asp 
                85                  90                  95      


Leu Tyr Asp Val Asp Ser Lys Ser Pro Asn Leu Ser Lys His Asp Phe 
            100                 105                 110         


Leu Gly Gln Val Phe Cys Thr Leu Gly Glu Ile Val Gly Ser Gln Gly 
        115                 120                 125             


Ser Arg Leu Glu Lys Pro Ile Val Gly Ile Pro Gly Lys Lys Cys Gly 
    130                 135                 140                 


Thr Ile Ile Leu Thr Ala Glu Glu Leu Asn Cys Cys Arg Asp Ala Val 
145                 150                 155                 160 


Leu Met Gln Phe Cys Ala Asn Lys Leu Asp Lys Lys Asp Phe Phe Gly 
                165                 170                 175     


Lys Ser Asp Pro Phe Leu Val Phe Tyr Arg Ser Asn Glu Asp Gly Ser 
            180                 185                 190         


Phe Thr Ile Cys His Lys Thr Glu Val Val Lys Asn Thr Leu Asn Pro 
        195                 200                 205             


Val Trp Gln Ala Phe Lys Ile Ser Val Arg Ala Leu Cys Asn Gly Asp 
    210                 215                 220                 


Tyr Asp Arg Thr Ile Lys Val Glu Val Tyr Asp Trp Asp Arg Asp Gly 
225                 230                 235                 240 


Ser His Asp Phe Ile Gly Glu Phe Thr Thr Ser Tyr Arg Glu Leu Ser 
                245                 250                 255     


Arg Gly Gln Ser Gln Phe Asn Val Tyr Glu Val Val Asn Pro Lys Lys 
            260                 265                 270         


Lys Gly Lys Lys Lys Lys Tyr Thr Asn Ser Gly Thr Val Thr Leu Leu 
        275                 280                 285             


Ser Phe Leu Val Glu Thr Glu Val Ser Phe Leu Asp Tyr Ile Lys Gly 
    290                 295                 300                 


Gly Thr Gln Ile Asn Phe Thr Val Ala Ile Asp Phe Thr Ala Ser Asn 
305                 310                 315                 320 


Gly Asn Pro Ala Gln Pro Thr Ser Leu His Tyr Met Asn Pro Tyr Gln 
                325                 330                 335     


Leu Asn Ala Tyr Gly Met Ala Leu Lys Ala Val Gly Glu Ile Val Gln 
            340                 345                 350         


Asp Tyr Asp Ser Asp Lys Met Phe Pro Ala Leu Gly Phe Gly Ala Lys 
        355                 360                 365             


Leu Pro Pro Asp Gly Arg Ile Ser His Glu Phe Ala Leu Asn Gly Asn 
    370                 375                 380                 


Pro Gln Asn Pro Tyr Cys Asp Gly Ile Glu Gly Val Met Glu Ala Tyr 
385                 390                 395                 400 


Tyr Arg Ser Leu Lys Ser Val Gln Leu Tyr Gly Pro Thr Asn Phe Ala 
                405                 410                 415     


Pro Val Ile Asn His Val Ala Arg Tyr Ala Ser Ser Val Lys Asp Gly 
            420                 425                 430         


Ser Gln Tyr Phe Val Leu Leu Ile Val Thr Asp Gly Val Ile Ser Asp 
        435                 440                 445             


Met Ala Gln Thr Lys Glu Ser Ile Val Asn Ala Ser Lys Leu Pro Met 
    450                 455                 460                 


Ser Ile Ile Ile Val Gly Val Gly Pro Ala Glu Phe Asp Ala Met Val 
465                 470                 475                 480 


Glu Leu Asp Gly Asp Asp Val Arg Val Ser Ser Arg Gly Lys Tyr Ala 
                485                 490                 495     


Glu Arg Asp Ile Val Gln Phe Val Pro Phe Arg Asp Tyr Ile Asp Arg 
            500                 505                 510         


Ser Gly Asn His Ile Leu Ser Met Ala Arg Leu Ala Lys Asp Val Leu 
        515                 520                 525             


Ala Glu Ile Pro Glu Gln Phe Leu Ser Tyr Met Arg Ala Arg Gly Ile 
    530                 535                 540                 


Lys Pro Ser Pro Ala Pro Pro Pro Tyr Thr Pro Pro Thr His Val Leu 
545                 550                 555                 560 


Gln Thr Gln Ile 
                


<210>  2960
<211>  2279
<212>  DNA
<213>  Homosapiens

<400>  2960
gctgacgggg tggcagtgcg gcgggttacg gcctggtcag accataatga cttcagcaaa     60

taaagcaatc gaattacaac tacaagtgaa acaaaatgca gaagaattac aagactttat    120

gcgggattta gaaaactggg aaaaagacat taaacaaaag gatatggaac taagaagaca    180

gaatggtgtt cctgaagaga atttacctcc tattcgaaat gggaatttta ggaaaaagaa    240

gaaaggcaaa gctaaagagt cttccaaaaa aaccagagag gaaaacacaa aaaacaggat    300

aaaatcttat gattatgagg catgggcaaa acttgatgtg gaccgtatcc ttgatgagct    360

tgacaaagac gatagtaccc atgagtctct gtctcaagaa tcagagtcgg aagaagatgg    420

gattcatgta gattcacaaa aggctcttgt tttaaaagaa aagggcaata aatacttcaa    480

acaaggaaaa tatgatgaag caattgactg ctacacaaaa ggcatggatg ccgatccata    540

taatcccgtg ttgccaacga acagagcgtc agcatatttt agactgaaaa aatttgctgt    600

tgctgagtct gattgtaatt tagcagttgc cttgaataga agttatacaa aggcttattc    660

cagacgaggt gctgctcgat ttgctttgca aaaattagaa gaggccaaaa aagattatga    720

aagagtatta gaactagaac caaataactt tgaagcaaca aatgaactca ggaaaatcag    780

tcaggcttta gcatccaaag aaaactcata tccaaaggaa gctgacatag tgattaagtc    840

aacagaagga gagcgaaagc aaattgaagc acaacagaat aagcagcagg ccatttcaga    900

gaaagatcgg gggaatggat ttttcaaaga ggggaaatat gaaagagcaa ttgaatgcta    960

tactcgaggg atagcagcag atggtgctaa tgcccttctt ccagctaaca gagctatggc   1020

ctatctgaag attcagaaat atgaagaagc tgaaaaagac tgcacacaag ccattttatt   1080

agatggctca tattctaaag cttttgccag aagaggaact gcaagaacat ttttgggaaa   1140

gctaaatgag gcaaaacaag attttgaaac tgttttactt ctggaacctg gaaataagca   1200

agcagtaact gaactctcca aaattaaaaa ggaattaatt gagaaaggac actgggatga   1260

tgtctttctt gattccacac aaagacaaaa tgtggtaaaa cccattgata atccaccgca   1320

tcctggatca actaaaccac tcaagaaggt tattattgaa gaaactggta atttgataca   1380

gactattgat gtgccagata gcactactgc tgctgctcca gagaataatc ctattaatct   1440

agcaaatgta atagcagcca caggcaccac aagtaagaag aattcaagcc aagatgtcct   1500

ttttcccaca agtgatactc caagagcaaa agtattgaaa atagaagaag tcagtgatac   1560

ttcatccctg caacctcaag ccagtttgaa gcaggatgta tgtcagtctt acagcgagaa   1620

aatgcccata gagatagaac aaaaacctgc tcagtttgcc acaactgttc ttcctccaat   1680

tcctgcaaac tcgttccagc tcgaatctga tttcagacaa ttgaaaagtt ctccagatat   1740

gttgtatcag tatttaaagc aaattgaacc atctttgtat cctaagttgt ttcagaaaaa   1800

tctggatcca gatgtattca accagatcgt taaaattctg catgactttt acattgagaa   1860

agaaaagcca ttactcatct ttgaaatctt acaaagactt tctgaactaa aaaggtttga   1920

tatggcagtg atgtttatgt cagaaacaga gaaaaagatt gcacgtgcat tatttaatca   1980

catagacaag tcaggattga aggatagttc tgtcgaagaa ctcaagaaaa gatacggtgg   2040

ttgatttcca tttttgctga aataattgtt tttgactttc atatgtaaat tttttctact   2100

gaaagtgttt tgctttttaa gaaaatgaaa ttatatagca ggaaaggact atctttgaac   2160

ataagttaat taactataag gtgaattgtg atttaactag tgagaattgt attcaagtga   2220

actctgtttt tctgaaaata aaaatataaa caatgagaaa aaaaaaaaaa aaaaaaaaa    2279


<210>  2961
<211>  665
<212>  PRT
<213>  Homosapiens

<400>  2961

Met Thr Ser Ala Asn Lys Ala Ile Glu Leu Gln Leu Gln Val Lys Gln 
1               5                   10                  15      


Asn Ala Glu Glu Leu Gln Asp Phe Met Arg Asp Leu Glu Asn Trp Glu 
            20                  25                  30          


Lys Asp Ile Lys Gln Lys Asp Met Glu Leu Arg Arg Gln Asn Gly Val 
        35                  40                  45              


Pro Glu Glu Asn Leu Pro Pro Ile Arg Asn Gly Asn Phe Arg Lys Lys 
    50                  55                  60                  


Lys Lys Gly Lys Ala Lys Glu Ser Ser Lys Lys Thr Arg Glu Glu Asn 
65                  70                  75                  80  


Thr Lys Asn Arg Ile Lys Ser Tyr Asp Tyr Glu Ala Trp Ala Lys Leu 
                85                  90                  95      


Asp Val Asp Arg Ile Leu Asp Glu Leu Asp Lys Asp Asp Ser Thr His 
            100                 105                 110         


Glu Ser Leu Ser Gln Glu Ser Glu Ser Glu Glu Asp Gly Ile His Val 
        115                 120                 125             


Asp Ser Gln Lys Ala Leu Val Leu Lys Glu Lys Gly Asn Lys Tyr Phe 
    130                 135                 140                 


Lys Gln Gly Lys Tyr Asp Glu Ala Ile Asp Cys Tyr Thr Lys Gly Met 
145                 150                 155                 160 


Asp Ala Asp Pro Tyr Asn Pro Val Leu Pro Thr Asn Arg Ala Ser Ala 
                165                 170                 175     


Tyr Phe Arg Leu Lys Lys Phe Ala Val Ala Glu Ser Asp Cys Asn Leu 
            180                 185                 190         


Ala Val Ala Leu Asn Arg Ser Tyr Thr Lys Ala Tyr Ser Arg Arg Gly 
        195                 200                 205             


Ala Ala Arg Phe Ala Leu Gln Lys Leu Glu Glu Ala Lys Lys Asp Tyr 
    210                 215                 220                 


Glu Arg Val Leu Glu Leu Glu Pro Asn Asn Phe Glu Ala Thr Asn Glu 
225                 230                 235                 240 


Leu Arg Lys Ile Ser Gln Ala Leu Ala Ser Lys Glu Asn Ser Tyr Pro 
                245                 250                 255     


Lys Glu Ala Asp Ile Val Ile Lys Ser Thr Glu Gly Glu Arg Lys Gln 
            260                 265                 270         


Ile Glu Ala Gln Gln Asn Lys Gln Gln Ala Ile Ser Glu Lys Asp Arg 
        275                 280                 285             


Gly Asn Gly Phe Phe Lys Glu Gly Lys Tyr Glu Arg Ala Ile Glu Cys 
    290                 295                 300                 


Tyr Thr Arg Gly Ile Ala Ala Asp Gly Ala Asn Ala Leu Leu Pro Ala 
305                 310                 315                 320 


Asn Arg Ala Met Ala Tyr Leu Lys Ile Gln Lys Tyr Glu Glu Ala Glu 
                325                 330                 335     


Lys Asp Cys Thr Gln Ala Ile Leu Leu Asp Gly Ser Tyr Ser Lys Ala 
            340                 345                 350         


Phe Ala Arg Arg Gly Thr Ala Arg Thr Phe Leu Gly Lys Leu Asn Glu 
        355                 360                 365             


Ala Lys Gln Asp Phe Glu Thr Val Leu Leu Leu Glu Pro Gly Asn Lys 
    370                 375                 380                 


Gln Ala Val Thr Glu Leu Ser Lys Ile Lys Lys Glu Leu Ile Glu Lys 
385                 390                 395                 400 


Gly His Trp Asp Asp Val Phe Leu Asp Ser Thr Gln Arg Gln Asn Val 
                405                 410                 415     


Val Lys Pro Ile Asp Asn Pro Pro His Pro Gly Ser Thr Lys Pro Leu 
            420                 425                 430         


Lys Lys Val Ile Ile Glu Glu Thr Gly Asn Leu Ile Gln Thr Ile Asp 
        435                 440                 445             


Val Pro Asp Ser Thr Thr Ala Ala Ala Pro Glu Asn Asn Pro Ile Asn 
    450                 455                 460                 


Leu Ala Asn Val Ile Ala Ala Thr Gly Thr Thr Ser Lys Lys Asn Ser 
465                 470                 475                 480 


Ser Gln Asp Val Leu Phe Pro Thr Ser Asp Thr Pro Arg Ala Lys Val 
                485                 490                 495     


Leu Lys Ile Glu Glu Val Ser Asp Thr Ser Ser Leu Gln Pro Gln Ala 
            500                 505                 510         


Ser Leu Lys Gln Asp Val Cys Gln Ser Tyr Ser Glu Lys Met Pro Ile 
        515                 520                 525             


Glu Ile Glu Gln Lys Pro Ala Gln Phe Ala Thr Thr Val Leu Pro Pro 
    530                 535                 540                 


Ile Pro Ala Asn Ser Phe Gln Leu Glu Ser Asp Phe Arg Gln Leu Lys 
545                 550                 555                 560 


Ser Ser Pro Asp Met Leu Tyr Gln Tyr Leu Lys Gln Ile Glu Pro Ser 
                565                 570                 575     


Leu Tyr Pro Lys Leu Phe Gln Lys Asn Leu Asp Pro Asp Val Phe Asn 
            580                 585                 590         


Gln Ile Val Lys Ile Leu His Asp Phe Tyr Ile Glu Lys Glu Lys Pro 
        595                 600                 605             


Leu Leu Ile Phe Glu Ile Leu Gln Arg Leu Ser Glu Leu Lys Arg Phe 
    610                 615                 620                 


Asp Met Ala Val Met Phe Met Ser Glu Thr Glu Lys Lys Ile Ala Arg 
625                 630                 635                 640 


Ala Leu Phe Asn His Ile Asp Lys Ser Gly Leu Lys Asp Ser Ser Val 
                645                 650                 655     


Glu Glu Leu Lys Lys Arg Tyr Gly Gly 
            660                 665 


<210>  2962
<211>  2321
<212>  DNA
<213>  Homosapiens

<400>  2962
cttcctgaaa ggatctggag acaccagctc cacaagtcct ggtgtcttta aaaggatcag     60

cttgaggaat aaggctcgtc tgagagctgt gacattcatc tgactctagt gaaagtccaa    120

cagccactcc ctttttggcc tccaactggg caccatgagg gcctgcatct ccctggtatt    180

ggccgtgctg tgtggcctgg cctgggctga ggaccacaaa gagtcagagc cattgccaca    240

gctggaggaa gagacagaag aggccctcgc cagcaacttg tactcggcac ccacctcctg    300

ccagggccgc tgctacgaag cctttgacaa gcaccaccaa tgtcactgca atgcccgctg    360

ccaagagttt gggaactgct gcaaggattt tgagagcctg tgtagtgacc acgaggtctc    420

ccacagcagt gatgccataa caaaagagga gattcagagc atctctgaga agatctacag    480

ggcagacacc aacaaagccc agaaggaaga catcgttctc aatagccaaa actgcatctc    540

cccgtcagag accagaaacc aagtggatcg ctgcccaaag ccactcttca cttatgtcaa    600

tgagaagctg ttctccaagc ccacctatgc agccttcatc aacctcctca acaactacca    660

gcgggcaaca ggccatgggg agcacttcag tgcccaggag ctggccgagc aggacgcctt    720

cctcagagag atcatgaaga cagcagtcat gaaggagctc tacagcttcc tccatcacca    780

gaatcgctat ggctcagagc aagagtttgt cgatgacttg aagaacatgt ggtttgggct    840

ctattcaaga ggcaatgaag agggggactc gagtggcttt gaacatgtct tctcaggtga    900

ggtaaaaaaa ggcaaggtta ctggcttcca taactggatc cgcttctacc tggaggagaa    960

ggagggtctg gttgactatt acagtcacat ctacgatggg ccttgggatt cttaccccga   1020

tgtgctggca atgcagttca actgggacgg ctactataag gaagtgggct ctgctttcat   1080

cggcagcagc cctgagtttg agtttgcact ctactccctg tgcttcatcg ccaggccagg   1140

caaagtgtgc cagttaagcc tgggaggata tcccttagct gtccggacat atacctggga   1200

caagtccacc tatgggaatg gcaagaagta catcgccaca gcctacatag tgtcttccac   1260

ctaatagaac ttcgagccag aaaggggcat gagggctctt gcgagactga agtgctatct   1320

tctctggact agagagaaga gggagaggac tggaagggat caccaaatct caaagcaatg   1380

agaagcattc ctaaatccca aagtgcccac atgggaaaga gataaaatgt acaaattaga   1440

aaaatgtgga taaacagtca aacctttatc ctctagaatt ttggcaatgt tgactaagaa   1500

acagagtcca agcagagaag gtaggaaccc tccatagctc tctgccctga tgtgtggggg   1560

aactaggaag aagtcctttg acctcaccag gcctcatgct tccctttaat gtaaagggaa   1620

ggggtttgcc cactttcctc tttttggggt tggtgagagg gcaaaccctg atatttttac   1680

tgtgaaggtg ttttcagttg ttcttaggaa gaacagctga tagaaattca agattactat   1740

aatggctgtt attatacaca gctctgtaaa ctaccactca gccctgtgtt ggggtcctca   1800

aagaagtaag gccacagtaa tcaagcaagg gcctttggtt ttttccagag ttagatcctc   1860

tcagaacaga gtctgggaga actccaatgc tgaatggaga agggtaatag gttggtgcag   1920

tgaatgggct gggggtgggg tggccttctc caggcctgag tgtttttgtg tccagctcag   1980

tatctgcaac aagaagtttc ccacttgtgg atgtttagtg cagccacaga cttgtatttt   2040

gatccccaat ttttttttga aagagttctc ctcataggag gatgattcag catcagaaga   2100

agaaggaacc catagcttgg tgtcattaac ataattattt taagccttat ccagcagcca   2160

taatttgaat aactctacga gaccagagag actgtagttc cctattttaa cctcaattat   2220

gcatttgtcc cccaacccca ctgagaacta aatgctgtac cacagagccg ggtgtgaact   2280

atggtttaga aggttcaagt ttccaattaa agtcattgaa g                       2321


<210>  2963
<211>  369
<212>  PRT
<213>  Homosapiens

<400>  2963

Met Arg Ala Cys Ile Ser Leu Val Leu Ala Val Leu Cys Gly Leu Ala 
1               5                   10                  15      


Trp Ala Glu Asp His Lys Glu Ser Glu Pro Leu Pro Gln Leu Glu Glu 
            20                  25                  30          


Glu Thr Glu Glu Ala Leu Ala Ser Asn Leu Tyr Ser Ala Pro Thr Ser 
        35                  40                  45              


Cys Gln Gly Arg Cys Tyr Glu Ala Phe Asp Lys His His Gln Cys His 
    50                  55                  60                  


Cys Asn Ala Arg Cys Gln Glu Phe Gly Asn Cys Cys Lys Asp Phe Glu 
65                  70                  75                  80  


Ser Leu Cys Ser Asp His Glu Val Ser His Ser Ser Asp Ala Ile Thr 
                85                  90                  95      


Lys Glu Glu Ile Gln Ser Ile Ser Glu Lys Ile Tyr Arg Ala Asp Thr 
            100                 105                 110         


Asn Lys Ala Gln Lys Glu Asp Ile Val Leu Asn Ser Gln Asn Cys Ile 
        115                 120                 125             


Ser Pro Ser Glu Thr Arg Asn Gln Val Asp Arg Cys Pro Lys Pro Leu 
    130                 135                 140                 


Phe Thr Tyr Val Asn Glu Lys Leu Phe Ser Lys Pro Thr Tyr Ala Ala 
145                 150                 155                 160 


Phe Ile Asn Leu Leu Asn Asn Tyr Gln Arg Ala Thr Gly His Gly Glu 
                165                 170                 175     


His Phe Ser Ala Gln Glu Leu Ala Glu Gln Asp Ala Phe Leu Arg Glu 
            180                 185                 190         


Ile Met Lys Thr Ala Val Met Lys Glu Leu Tyr Ser Phe Leu His His 
        195                 200                 205             


Gln Asn Arg Tyr Gly Ser Glu Gln Glu Phe Val Asp Asp Leu Lys Asn 
    210                 215                 220                 


Met Trp Phe Gly Leu Tyr Ser Arg Gly Asn Glu Glu Gly Asp Ser Ser 
225                 230                 235                 240 


Gly Phe Glu His Val Phe Ser Gly Glu Val Lys Lys Gly Lys Val Thr 
                245                 250                 255     


Gly Phe His Asn Trp Ile Arg Phe Tyr Leu Glu Glu Lys Glu Gly Leu 
            260                 265                 270         


Val Asp Tyr Tyr Ser His Ile Tyr Asp Gly Pro Trp Asp Ser Tyr Pro 
        275                 280                 285             


Asp Val Leu Ala Met Gln Phe Asn Trp Asp Gly Tyr Tyr Lys Glu Val 
    290                 295                 300                 


Gly Ser Ala Phe Ile Gly Ser Ser Pro Glu Phe Glu Phe Ala Leu Tyr 
305                 310                 315                 320 


Ser Leu Cys Phe Ile Ala Arg Pro Gly Lys Val Cys Gln Leu Ser Leu 
                325                 330                 335     


Gly Gly Tyr Pro Leu Ala Val Arg Thr Tyr Thr Trp Asp Lys Ser Thr 
            340                 345                 350         


Tyr Gly Asn Gly Lys Lys Tyr Ile Ala Thr Ala Tyr Ile Val Ser Ser 
        355                 360                 365             


Thr 
    


<210>  2964
<211>  3327
<212>  DNA
<213>  Homosapiens

<400>  2964
gcccccaccc ctctactcac ccaagaggag cctctccacc gagccctgca tcctgctgcc     60

ctggcagcca gtccagctag gcactggccc agttcactgt acctggactt acccactggc    120

accctccgga tccccttatc aaagctgatg ggggtcgctg gggacccccc agccttttgc    180

tagagcctgc acggctgtgc gagcttgaaa agaaacatga aggtgggctg gccaggtgag    240

agctgctggc aggtgggcct ggctgtggag gatagcccag ctctgggagc accgcgggtg    300

ggagccctcc ctgacgtggt gccggagggg acactactca acatggtgtt gagaaggatg    360

caccggcccc gaagctgctc ctaccagctg ctgctggagc accagcgtcc gagctgcatc    420

caggggctgc gctggacacc actcaccaac agcgaggagt ccctggattt cagcgagagc    480

ctggagcagg cctccacaga gcgggtgctc agggctggga ggcagctgca tcggcatctg    540

ctggccacct gcccaaacct catccgagac cggaagtacc accttaggct ctatcggcag    600

tgctgctctg gccgggagct ggtggatggg atcttggccc tgggacttgg ggtccattcc    660

cggagccaag ttgtgggaat ctgccaggtg ctgctggatg aaggtgccct ctgccatgtg    720

aaacacgact gggccttcca ggaccgagat gcccaattct accggttccc cgggcccgag    780

cccgagcccg tgggaactca tgagatggag gaggagttgg ccgaagctgt ggccctgctc    840

tcccagcggg ggcctgacgc cctgctcact gtggcacttc gaaagccccc aggtcagcgc    900

acggatgaag agctggacct catctttgag gagctgctgc acatcaaggc tgtggcccac    960

ctctccaact cggtgaagcg agaattagcg gctgttctgc tctttgaacc acacagcaag   1020

gcagggaccg tgttgttcag ccagggggac aagggcactt cgtggtacat tatctggaag   1080

ggatctgtca acgtggtgac ccatggcaag gggctggtga ccaccctgca tgagggagat   1140

gattttggac agctggctct ggtgaatgat gcaccccggg cagccaccat catcctgcga   1200

gaagacaact gtcatttcct gcgtgtggac aagcaggact tcaaccgtat catcaaggat   1260

gtggaggcaa agaccatgcg gctggaagaa catggcaaag tggtgctggt gctggagaga   1320

gcctctcagg gcgccggccc ttcccgaccc ccaaccccag gcaggaaccg gtatacagtg   1380

atgtctggca ccccagagaa gatcctagag cttctgttgg aggccatggg accagattcc   1440

agtgctcatg acccaacaga gacattcctc agcgacttcc tcctgaccca cagggtcttc   1500

atgcccagcg cccaactctg cgctgccctt ctgcaccact tccatgtgga gcctgcgggt   1560

ggcagcgagc aggagcgcag cacctacgtc tgcaacaaga ggcagcagat cttgcggctg   1620

gtcagccagt gggtggccct gtatggctcc atgctccaca ctgaccctgt ggccaccagc   1680

ttcctccaga aactctcaga cctggtgggc agggacaccc gactcagcaa cctgctgagg   1740

gagcagtggc cagagaggcg gcgatgccac aggttggaga atggctgtgg gaatgcatct   1800

cctcagatga aggcccggaa cttgcctgtt tggctcccca accaggacga gccccttcct   1860

ggcagcagct gtgccatcca agttggggat aaagtcccct atgacatctg ccggccagac   1920

cactcagtgt tgaccctgca gctgcctgtg acagcctccg tgagagaggt gatggcagcg   1980

ttggcccagg aggatggctg gaccaagggg caggtgctgg tgaaggtcaa ttctgcaggt   2040

gatgccattg gcctgcagcc agatgcccgt ggtgtggcca catctctggg gctcaatgag   2100

cgtctctttg ttgtcaaccc acaggaagtg catgagctga tcccacaccc tgaccagctg   2160

gggcccactg tgggctctgc tgaggggctg gacctggtga gtgccaagga cctggcaggc   2220

cagctgacgg accacgactg gagcctcttc aacagtatcc accaggtgga gctgatccac   2280

tatgtgctgg gcccccagca tctgcgggat gtcaccaccg ccaacctgga gcgcttcatg   2340

cgccgcttca atgagctgca gtactgggtg gccaccgagc tgtgtctctg ccccgtgccc   2400

ggcccccggg cccagctgct caggaagttc attaagctgg cggcccacct caaggagcag   2460

aagaatctca attccttctt tgccgtcatg tttggcctca gcaactcggc catcagccgc   2520

ctagcccaca cctgggagcg gctgcctcac aaagtccgga agctgtactc cgccctcgag   2580

aggctgctgg atccctcatg gaaccaccgg gtataccgac tggccctcgc caagctctcc   2640

cctcctgtca tccccttcat gccccttctt ctcaaagaca tgaccttcat tcatgaggga   2700

aaccacacac tagtggagaa tctcatcaac tttgagaaga tgagaatgat ggccagagcc   2760

gcgcggatgc tgcaccactg ccgaagccac aaccctgtgc ctctctcacc actcagaagc   2820

cgagtttccc acctccacga ggacagccag gtggcgagga tttccacatg ctcggagcag   2880

tccctgagca cccggagtcc agccagcacc tgggcttatg tccagcagct gaaggtcatt   2940

gacaaccagc gggaactctc ccgcctctcc cgagagctgg agccatgagg aggggctggg   3000

actggagctg gagcaggcac ttgcagccgg gaaagccagg gtgtgccggg ccaagatact   3060

cacaggctgg ccacagctgg gcaaggctct ccgtggagtg gactcgagtc cctggagcag   3120

gcagtgtgga ggcagccatc ccctgtgatg actggcagct aaggaggacc tcggagtgga   3180

cccgagccag gaataacgaa tgacccaagg ccaaggaagg gaggacagag aggccccagg   3240

agtgggtgga gagtggagtg cgctgggacg ttgtgtgcaa tagagaggtc tccacaccag   3300

atgtcttcca gaaaaaaaaa aaaaaaa                                       3327


<210>  2965
<211>  881
<212>  PRT
<213>  Homosapiens

<400>  2965

Met Val Leu Arg Arg Met His Arg Pro Arg Ser Cys Ser Tyr Gln Leu 
1               5                   10                  15      


Leu Leu Glu His Gln Arg Pro Ser Cys Ile Gln Gly Leu Arg Trp Thr 
            20                  25                  30          


Pro Leu Thr Asn Ser Glu Glu Ser Leu Asp Phe Ser Glu Ser Leu Glu 
        35                  40                  45              


Gln Ala Ser Thr Glu Arg Val Leu Arg Ala Gly Arg Gln Leu His Arg 
    50                  55                  60                  


His Leu Leu Ala Thr Cys Pro Asn Leu Ile Arg Asp Arg Lys Tyr His 
65                  70                  75                  80  


Leu Arg Leu Tyr Arg Gln Cys Cys Ser Gly Arg Glu Leu Val Asp Gly 
                85                  90                  95      


Ile Leu Ala Leu Gly Leu Gly Val His Ser Arg Ser Gln Val Val Gly 
            100                 105                 110         


Ile Cys Gln Val Leu Leu Asp Glu Gly Ala Leu Cys His Val Lys His 
        115                 120                 125             


Asp Trp Ala Phe Gln Asp Arg Asp Ala Gln Phe Tyr Arg Phe Pro Gly 
    130                 135                 140                 


Pro Glu Pro Glu Pro Val Gly Thr His Glu Met Glu Glu Glu Leu Ala 
145                 150                 155                 160 


Glu Ala Val Ala Leu Leu Ser Gln Arg Gly Pro Asp Ala Leu Leu Thr 
                165                 170                 175     


Val Ala Leu Arg Lys Pro Pro Gly Gln Arg Thr Asp Glu Glu Leu Asp 
            180                 185                 190         


Leu Ile Phe Glu Glu Leu Leu His Ile Lys Ala Val Ala His Leu Ser 
        195                 200                 205             


Asn Ser Val Lys Arg Glu Leu Ala Ala Val Leu Leu Phe Glu Pro His 
    210                 215                 220                 


Ser Lys Ala Gly Thr Val Leu Phe Ser Gln Gly Asp Lys Gly Thr Ser 
225                 230                 235                 240 


Trp Tyr Ile Ile Trp Lys Gly Ser Val Asn Val Val Thr His Gly Lys 
                245                 250                 255     


Gly Leu Val Thr Thr Leu His Glu Gly Asp Asp Phe Gly Gln Leu Ala 
            260                 265                 270         


Leu Val Asn Asp Ala Pro Arg Ala Ala Thr Ile Ile Leu Arg Glu Asp 
        275                 280                 285             


Asn Cys His Phe Leu Arg Val Asp Lys Gln Asp Phe Asn Arg Ile Ile 
    290                 295                 300                 


Lys Asp Val Glu Ala Lys Thr Met Arg Leu Glu Glu His Gly Lys Val 
305                 310                 315                 320 


Val Leu Val Leu Glu Arg Ala Ser Gln Gly Ala Gly Pro Ser Arg Pro 
                325                 330                 335     


Pro Thr Pro Gly Arg Asn Arg Tyr Thr Val Met Ser Gly Thr Pro Glu 
            340                 345                 350         


Lys Ile Leu Glu Leu Leu Leu Glu Ala Met Gly Pro Asp Ser Ser Ala 
        355                 360                 365             


His Asp Pro Thr Glu Thr Phe Leu Ser Asp Phe Leu Leu Thr His Arg 
    370                 375                 380                 


Val Phe Met Pro Ser Ala Gln Leu Cys Ala Ala Leu Leu His His Phe 
385                 390                 395                 400 


His Val Glu Pro Ala Gly Gly Ser Glu Gln Glu Arg Ser Thr Tyr Val 
                405                 410                 415     


Cys Asn Lys Arg Gln Gln Ile Leu Arg Leu Val Ser Gln Trp Val Ala 
            420                 425                 430         


Leu Tyr Gly Ser Met Leu His Thr Asp Pro Val Ala Thr Ser Phe Leu 
        435                 440                 445             


Gln Lys Leu Ser Asp Leu Val Gly Arg Asp Thr Arg Leu Ser Asn Leu 
    450                 455                 460                 


Leu Arg Glu Gln Trp Pro Glu Arg Arg Arg Cys His Arg Leu Glu Asn 
465                 470                 475                 480 


Gly Cys Gly Asn Ala Ser Pro Gln Met Lys Ala Arg Asn Leu Pro Val 
                485                 490                 495     


Trp Leu Pro Asn Gln Asp Glu Pro Leu Pro Gly Ser Ser Cys Ala Ile 
            500                 505                 510         


Gln Val Gly Asp Lys Val Pro Tyr Asp Ile Cys Arg Pro Asp His Ser 
        515                 520                 525             


Val Leu Thr Leu Gln Leu Pro Val Thr Ala Ser Val Arg Glu Val Met 
    530                 535                 540                 


Ala Ala Leu Ala Gln Glu Asp Gly Trp Thr Lys Gly Gln Val Leu Val 
545                 550                 555                 560 


Lys Val Asn Ser Ala Gly Asp Ala Ile Gly Leu Gln Pro Asp Ala Arg 
                565                 570                 575     


Gly Val Ala Thr Ser Leu Gly Leu Asn Glu Arg Leu Phe Val Val Asn 
            580                 585                 590         


Pro Gln Glu Val His Glu Leu Ile Pro His Pro Asp Gln Leu Gly Pro 
        595                 600                 605             


Thr Val Gly Ser Ala Glu Gly Leu Asp Leu Val Ser Ala Lys Asp Leu 
    610                 615                 620                 


Ala Gly Gln Leu Thr Asp His Asp Trp Ser Leu Phe Asn Ser Ile His 
625                 630                 635                 640 


Gln Val Glu Leu Ile His Tyr Val Leu Gly Pro Gln His Leu Arg Asp 
                645                 650                 655     


Val Thr Thr Ala Asn Leu Glu Arg Phe Met Arg Arg Phe Asn Glu Leu 
            660                 665                 670         


Gln Tyr Trp Val Ala Thr Glu Leu Cys Leu Cys Pro Val Pro Gly Pro 
        675                 680                 685             


Arg Ala Gln Leu Leu Arg Lys Phe Ile Lys Leu Ala Ala His Leu Lys 
    690                 695                 700                 


Glu Gln Lys Asn Leu Asn Ser Phe Phe Ala Val Met Phe Gly Leu Ser 
705                 710                 715                 720 


Asn Ser Ala Ile Ser Arg Leu Ala His Thr Trp Glu Arg Leu Pro His 
                725                 730                 735     


Lys Val Arg Lys Leu Tyr Ser Ala Leu Glu Arg Leu Leu Asp Pro Ser 
            740                 745                 750         


Trp Asn His Arg Val Tyr Arg Leu Ala Leu Ala Lys Leu Ser Pro Pro 
        755                 760                 765             


Val Ile Pro Phe Met Pro Leu Leu Leu Lys Asp Met Thr Phe Ile His 
    770                 775                 780                 


Glu Gly Asn His Thr Leu Val Glu Asn Leu Ile Asn Phe Glu Lys Met 
785                 790                 795                 800 


Arg Met Met Ala Arg Ala Ala Arg Met Leu His His Cys Arg Ser His 
                805                 810                 815     


Asn Pro Val Pro Leu Ser Pro Leu Arg Ser Arg Val Ser His Leu His 
            820                 825                 830         


Glu Asp Ser Gln Val Ala Arg Ile Ser Thr Cys Ser Glu Gln Ser Leu 
        835                 840                 845             


Ser Thr Arg Ser Pro Ala Ser Thr Trp Ala Tyr Val Gln Gln Leu Lys 
    850                 855                 860                 


Val Ile Asp Asn Gln Arg Glu Leu Ser Arg Leu Ser Arg Glu Leu Glu 
865                 870                 875                 880 


Pro 
    


<210>  2966
<211>  1950
<212>  DNA
<213>  Homosapiens

<400>  2966
gctctggcgg ctcccgcggc tccggctggc ggcttcgggc cctgcacctg tgactctcgg     60

ccgcgctcgc cctcggcccg cccggcgccg cagccccatg gccccgtcca ggctgcagct    120

cggcctccgc gccgcctact ccggcatcag ctccgtggcc ggcttctcca tcttcctcgt    180

ctggacggtg gtctaccgac agccggggac cgcggccatg ggagggctcg caggggtgct    240

ggcactgtgg gtcctggtga cgcacgtgat gtacatgcaa gattattgga ggacctggct    300

caaggggctg cgcggcttct tcttcgtggg ggtcctcttc tcggccgtct ccatcgctgc    360

cttctgcacc ttcctcgtgc tggccatcac ccggcatcag agcctcacag accccaccag    420

ctactacctc tccagcgtct ggagcttcat ttccttcaag tgggccttcc tgctcagcct    480

ctatgcccac cgctaccggg ctgactttgc tgacatcagc atcctcagcg atttctgacc    540

cagggggtga ggtctctgca ccctgggggg gccttaggac ctggactcag cctctgagat    600

gttgggagag gctactccca ccccctggtg accccagaac tgtggcagaa aatacacagc    660

aggacgagtg tggtctccca ggaagctgtc ctgcccgtcc cctttcgagg aaacctgagt    720

gtggtagaga ggggatcctg ccatgttgct cctcatcagc ctggccagag ggcagcttta    780

gaccttttca aatgaatctg ttttcttttc tttctttttt ttttcttttt tttttttttt    840

tgagatggag tcttactctg tcacccaggc tggagtgcag tagtgcgatc tcagctcact    900

gcaacctccg cctcccaggt tcaagcaatt ctcctgcctt ggcctctcaa gtagctggga    960

ttacaggcat ctgccaccat gcccggcaaa tttttgtgtt tttagtagag acagggtttt   1020

gccatgttgg ccaggctggt ctcgaactcc tgatctcagg tgattcaccc gcctcagcct   1080

tccaaagtgc tgggattata ggtgtgagcc accgtgcccg gcctggatct gttttcttag   1140

cacgcagtga ggaatctttg tacttaaggc cagggcaaca aagtcaagag gtcaaggtgt   1200

agggccatga ggcctggacc tatgctgcag gcaagggttt ccatccccgc tgccctaggc   1260

actctcttcc caaggccagg ttgggcacct ggggaggtca gttcagaaat atctagcaga   1320

gacctcttaa acccccatcc cagcacccca tcctgttgtt cccagagctg gtctcccatg   1380

agtgtgctag agccagatag ccgtggcccc ccacccatct cactcacaca cacaggcatc   1440

catacacccc agaagacttc ccaaatgagg ccagactcag ggtcacgggg aatgtgcttc   1500

tgcccctgta agggctttgg ggaagggggc aacatagtag aggctggaaa gagcccccaa   1560

acctgtgccc atgcccctcc agccctgcgt ttccattctg ccttctcaga gtgcccttgc   1620

tgcacccaga ccaccggcca ggagagacct tctctcccac tccagcccct ctcactgccc   1680

ttcaactaga gctttcacct ttttacattt cccttctgaa ggacacaaat ctgcttttct   1740

gcccatacac tggcccaagg gctcacctaa cttgggaggg aaggggctgt tggtacaagg   1800

atgattttct gttaggctgc cattttgcac ggtctccccc tccccatctg atgtgtcctg   1860

cccctcagct ctttgcctta tctgtgtcac tgtcacttta gcaaaaatac agcggccatt   1920

tgtatcaaaa aaaaaaaaaa aaaaaaaaaa                                    1950


<210>  2967
<211>  239
<212>  PRT
<213>  Homosapiens

<400>  2967

Met Pro Thr Ala Thr Gly Leu Thr Leu Leu Thr Ser Ala Ser Ser Ala 
1               5                   10                  15      


Ile Ser Asp Pro Gly Gly Glu Val Ser Ala Pro Trp Gly Gly Leu Arg 
            20                  25                  30          


Thr Trp Thr Gln Pro Leu Arg Cys Trp Glu Arg Leu Leu Pro Pro Pro 
        35                  40                  45              


Gly Asp Pro Arg Thr Val Ala Glu Asn Thr Gln Gln Asp Glu Cys Gly 
    50                  55                  60                  


Leu Pro Gly Ser Cys Pro Ala Arg Pro Leu Ser Arg Lys Pro Glu Cys 
65                  70                  75                  80  


Gly Arg Glu Gly Ile Leu Pro Cys Cys Ser Ser Ser Ala Trp Pro Glu 
                85                  90                  95      


Gly Ser Phe Arg Pro Phe Gln Met Asn Leu Phe Ser Phe Leu Ser Phe 
            100                 105                 110         


Phe Phe Leu Phe Phe Phe Phe Leu Arg Trp Ser Leu Thr Leu Ser Pro 
        115                 120                 125             


Arg Leu Glu Cys Ser Ser Ala Ile Ser Ala His Cys Asn Leu Arg Leu 
    130                 135                 140                 


Pro Gly Ser Ser Asn Ser Pro Ala Leu Ala Ser Gln Val Ala Gly Ile 
145                 150                 155                 160 


Thr Gly Ile Cys His His Ala Arg Gln Ile Phe Val Phe Leu Val Glu 
                165                 170                 175     


Thr Gly Phe Cys His Val Gly Gln Ala Gly Leu Glu Leu Leu Ile Ser 
            180                 185                 190         


Gly Asp Ser Pro Ala Ser Ala Phe Gln Ser Ala Gly Ile Ile Gly Val 
        195                 200                 205             


Ser His Arg Ala Arg Pro Gly Ser Val Phe Leu Ala Arg Ser Glu Glu 
    210                 215                 220                 


Ser Leu Tyr Leu Arg Pro Gly Gln Gln Ser Gln Glu Val Lys Val 
225                 230                 235                 


<210>  2968
<211>  4206
<212>  DNA
<213>  Homosapiens

<400>  2968
ataataccta ccttgcagga ccacgacagg attaagtgag gaaaaacccc catgagagtg     60

ttttgccatt gtcaagtgag cctgagggag gctgaggggg gatcaggctg tatcatgccc    120

ccgaggacaa actttccagt ttaccctgct ccctctctct gtccctaggc tgccccaggc    180

cctgtgcaga cacaccaggc cctcagccgc agcccatgga cctgcgggtg ggccagcggc    240

ccccagtgga gcccccacca gagcccacat tgctggccct gcagcgtccc cagcgcctgc    300

accaccacct cttcctagca ggcctgcagc agcagcgctc ggtggagccc atgaggctct    360

ccatggacac gccgatgccc gagttgcagg tgggacccca ggaacaagag ctgcggcagc    420

ttctccacaa ggacaagagc aagcgaagtg ctgtagccag cagcgtggtc aagcagaagc    480

tagcggaggt gattctgaaa aaacagcagg cggccctaga aagaacagtc catcccaaca    540

gccccggcat tccctacaga accctggagc ccctggagac ggaaggagcc acccgctcca    600

tgctcagcag ctttttgcct cctgttccca gcctgcccag tgacccccca gagcacttcc    660

ctctgcgcaa gacagtctct gagcccaacc tgaagctgcg ctataagccc aagaagtccc    720

tggagcggag gaagaatcca ctgctccgaa aggagagtgc gccccccagc ctccggcggc    780

ggcccgcaga gaccctcgga gactcctccc caagtagtag cagcacgccc gcatcagggt    840

gcagctcccc caatgacagc gagcacggcc ccaatcccat cctgggctcg gaggcgctct    900

tgggccagcg gctgcggctg caggagactt ctgtggcccc gttcgccttg ccgacagtgt    960

ccttgctgcc cgcaatcact ctggggctgc ccgcccctgc cagggctgac agtgaccgca   1020

ggacccatcc gactctgggc cctcgggggc caatcctggg gagcccccac actcccctct   1080

tcctgcccca tggcttggag cccgaggctg ggggcacctt gccctctcgc ctgcagccca   1140

ttctcctcct ggacccctca ggctctcatg ccccgctgct gactgtgccc gggcttgggc   1200

ccttgccctt ccactttgcc cagtccttaa tgaccaccga gcggctctct gggtcaggcc   1260

tccactggcc actgagccgg actcgctcag agcccctgcc ccccagtgcc accgctcccc   1320

caccgccggg ccccatgcag ccccgcctgg agcagctcaa aactcacgtc caggtgatca   1380

agaggtcagc caagccgagt gagaagcccc ggctgcggca gataccctcg gctgaagacc   1440

tggagacaga tggcggggga ccgggccagg tggtggacga tggcctggag cacagggagc   1500

tgggccatgg gcagcctgag gccagaggcc ccgctcctct ccagcagcac cctcaggtgt   1560

tgctctggga acagcagcga ctggctgggc ggctcccccg gggcagcacc ggggacactg   1620

tgctgcttcc tctggcccag ggtgggcacc ggcctctgtc ccgggctcag tcttccccag   1680

ccgcacctgc ctcactgtca gccccagagc ctgccagcca ggcccgagtc ctctccagct   1740

cagagacccc tgccaggacc ctgcccttca ccacagggct gatctatgac tcggtcatgc   1800

tgaagcacca gtgctcctgc ggtgacaaca gcaggcaccc ggagcacgcc ggccgcatcc   1860

agagcatctg gtcccggctg caggagcggg ggctccggag ccagtgtgag tgtctccgag   1920

gccggaaggc ctccctggaa gagctgcagt cggtccactc tgagcggcac gtgctcctct   1980

acggcaccaa cccgctcagc cgcctcaaac tggacaacgg gaagctggca gggctcctgg   2040

cacagcggat gtttgtgatg ctgccctgtg gtggggttgg ggtggacact gacaccatct   2100

ggaatgagct tcattcctcc aatgcagccc gctgggccgc tggcagtgtc actgacctcg   2160

ccttcaaagt ggcttctcgt gagctaaaga atggtttcgc tgtggtgcgg cccccaggac   2220

accatgcaga tcattcaaca gccatgggct tctgcttctt caactcagtg gccatcgcct   2280

gccggcagct gcaacagcag agcaaggcca gcaagatcct cattgtagac tgggacgtgc   2340

accatggcaa cggcacccag caaaccttct accaagaccc cagtgtgctc tacatctccc   2400

tgcatcgcca tgacgacggc aacttcttcc cggggagtgg ggctgtggat gaggtagggg   2460

ctggcagcgg tgagggcttc aatgtcaatg tggcctgggc tggaggtctg gaccccccca   2520

tgggggatcc tgagtacctg gctgctttca ggatagtcgt gatgcccatc gcccgagagt   2580

tctctccaga cctagtcctg gtgtctgctg gatttgatgc tgctgagggt cacccggccc   2640

cactgggtgg ctaccatgtt tctgccaaat gttttggata catgacgcag caactgatga   2700

acctggcagg aggcgcagtg gtgctggcct tggagggtgg ccatgacctc acagccatct   2760

gtgacgcctc tgaggcctgt gtggctgctc ttctgggtaa cagggtggat cccctttcag   2820

aagaaggctg gaaacagaaa cccaacctca atgccatccg ctctctggag gccgtgatcc   2880

gggtgcacag taaatactgg ggctgcatgc agcgcctggc ctcctgtcca gactcctggg   2940

tgcctagagt gccaggggct gacaaagaag aagtggaggc agtgaccgca ctggcgtccc   3000

tctctgtggg catcctggct gaagataggc cctcggagca gctggtggag gaggaagaac   3060

ctatgaatct ctaaggctct ggaaccatct gcccgcccac catgcccttg ggacctggtt   3120

ctcttctaac ccctggcaat agcccccatt cctgggtctt tagagatcct gtgggcaagt   3180

agttggaacc agagaacagc ctgcctgctt tgacagttat cccagggagc gtgagaaaat   3240

ccctgggtct agaatgggaa ctggagagga ccctgagagg agacgggctg ggcggcgacc   3300

cccacagggc tctcgagaac agattctccc ctccagtatg ggccctggct gtggccccca   3360

ttcctcagga ctgcacagag gaggactggc tccggctccg tcgggctcac ccttaaccac   3420

tattcctggc tctgcaaacc ccagactttg cacacagccc caggctccac acagaaatgt   3480

gaacttggcc tcagacaggc tggcccttcc taggctctag gggctagggg ggagtgggga   3540

gccaagaggt cccatattcc tgagtgcagg ggtagtccct ctcacctgct tcctcagacg   3600

actctggaag cttccctcta ccaccgggca ctgagacgaa gctccctgac agccgagact   3660

ggcagccctc catctggtcc gtaccctcgc cagaggcccc cctacatcaa cctcctggcg   3720

atgccctggt ggagcagatg ggtgctctgg gagtcctgtg cttcctgatc caatggtgcc   3780

aaacccttca tctcccccag aagcgcagca tacccctggg acccctcggc cactgcccac   3840

tcggggagcc ttctctgttt ctggggcctc ccccaccata gctctgattc ccaccccaca   3900

taggaatagc ctgactgagg gggaaggggt gggagagaag atacagacat ggaggagggg   3960

aggctgctct ggcaaagtct tcaaggcttt tgggggtcca ggcctggggt caagaaggaa   4020

aatgtgtgtg agcatgtgtg tgagtgaggc gtgtgtgtga gcgtgtgtgt gagtgaggcg   4080

tgtgtgtgtg tctttcctag gacccaccat accctgtgta tgtatgcatg tttttgtaaa   4140

aaggaagaaa atggaaaaaa atctgaacaa taaatgtttt atttgcttta aaaaaaaaaa   4200

aaaaaa                                                              4206


<210>  2969
<211>  952
<212>  PRT
<213>  Homosapiens

<400>  2969

Met Asp Leu Arg Val Gly Gln Arg Pro Pro Val Glu Pro Pro Pro Glu 
1               5                   10                  15      


Pro Thr Leu Leu Ala Leu Gln Arg Pro Gln Arg Leu His His His Leu 
            20                  25                  30          


Phe Leu Ala Gly Leu Gln Gln Gln Arg Ser Val Glu Pro Met Arg Leu 
        35                  40                  45              


Ser Met Asp Thr Pro Met Pro Glu Leu Gln Val Gly Pro Gln Glu Gln 
    50                  55                  60                  


Glu Leu Arg Gln Leu Leu His Lys Asp Lys Ser Lys Arg Ser Ala Val 
65                  70                  75                  80  


Ala Ser Ser Val Val Lys Gln Lys Leu Ala Glu Val Ile Leu Lys Lys 
                85                  90                  95      


Gln Gln Ala Ala Leu Glu Arg Thr Val His Pro Asn Ser Pro Gly Ile 
            100                 105                 110         


Pro Tyr Arg Thr Leu Glu Pro Leu Glu Thr Glu Gly Ala Thr Arg Ser 
        115                 120                 125             


Met Leu Ser Ser Phe Leu Pro Pro Val Pro Ser Leu Pro Ser Asp Pro 
    130                 135                 140                 


Pro Glu His Phe Pro Leu Arg Lys Thr Val Ser Glu Pro Asn Leu Lys 
145                 150                 155                 160 


Leu Arg Tyr Lys Pro Lys Lys Ser Leu Glu Arg Arg Lys Asn Pro Leu 
                165                 170                 175     


Leu Arg Lys Glu Ser Ala Pro Pro Ser Leu Arg Arg Arg Pro Ala Glu 
            180                 185                 190         


Thr Leu Gly Asp Ser Ser Pro Ser Ser Ser Ser Thr Pro Ala Ser Gly 
        195                 200                 205             


Cys Ser Ser Pro Asn Asp Ser Glu His Gly Pro Asn Pro Ile Leu Gly 
    210                 215                 220                 


Ser Glu Ala Leu Leu Gly Gln Arg Leu Arg Leu Gln Glu Thr Ser Val 
225                 230                 235                 240 


Ala Pro Phe Ala Leu Pro Thr Val Ser Leu Leu Pro Ala Ile Thr Leu 
                245                 250                 255     


Gly Leu Pro Ala Pro Ala Arg Ala Asp Ser Asp Arg Arg Thr His Pro 
            260                 265                 270         


Thr Leu Gly Pro Arg Gly Pro Ile Leu Gly Ser Pro His Thr Pro Leu 
        275                 280                 285             


Phe Leu Pro His Gly Leu Glu Pro Glu Ala Gly Gly Thr Leu Pro Ser 
    290                 295                 300                 


Arg Leu Gln Pro Ile Leu Leu Leu Asp Pro Ser Gly Ser His Ala Pro 
305                 310                 315                 320 


Leu Leu Thr Val Pro Gly Leu Gly Pro Leu Pro Phe His Phe Ala Gln 
                325                 330                 335     


Ser Leu Met Thr Thr Glu Arg Leu Ser Gly Ser Gly Leu His Trp Pro 
            340                 345                 350         


Leu Ser Arg Thr Arg Ser Glu Pro Leu Pro Pro Ser Ala Thr Ala Pro 
        355                 360                 365             


Pro Pro Pro Gly Pro Met Gln Pro Arg Leu Glu Gln Leu Lys Thr His 
    370                 375                 380                 


Val Gln Val Ile Lys Arg Ser Ala Lys Pro Ser Glu Lys Pro Arg Leu 
385                 390                 395                 400 


Arg Gln Ile Pro Ser Ala Glu Asp Leu Glu Thr Asp Gly Gly Gly Pro 
                405                 410                 415     


Gly Gln Val Val Asp Asp Gly Leu Glu His Arg Glu Leu Gly His Gly 
            420                 425                 430         


Gln Pro Glu Ala Arg Gly Pro Ala Pro Leu Gln Gln His Pro Gln Val 
        435                 440                 445             


Leu Leu Trp Glu Gln Gln Arg Leu Ala Gly Arg Leu Pro Arg Gly Ser 
    450                 455                 460                 


Thr Gly Asp Thr Val Leu Leu Pro Leu Ala Gln Gly Gly His Arg Pro 
465                 470                 475                 480 


Leu Ser Arg Ala Gln Ser Ser Pro Ala Ala Pro Ala Ser Leu Ser Ala 
                485                 490                 495     


Pro Glu Pro Ala Ser Gln Ala Arg Val Leu Ser Ser Ser Glu Thr Pro 
            500                 505                 510         


Ala Arg Thr Leu Pro Phe Thr Thr Gly Leu Ile Tyr Asp Ser Val Met 
        515                 520                 525             


Leu Lys His Gln Cys Ser Cys Gly Asp Asn Ser Arg His Pro Glu His 
    530                 535                 540                 


Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Arg Gly Leu 
545                 550                 555                 560 


Arg Ser Gln Cys Glu Cys Leu Arg Gly Arg Lys Ala Ser Leu Glu Glu 
                565                 570                 575     


Leu Gln Ser Val His Ser Glu Arg His Val Leu Leu Tyr Gly Thr Asn 
            580                 585                 590         


Pro Leu Ser Arg Leu Lys Leu Asp Asn Gly Lys Leu Ala Gly Leu Leu 
        595                 600                 605             


Ala Gln Arg Met Phe Val Met Leu Pro Cys Gly Gly Val Gly Val Asp 
    610                 615                 620                 


Thr Asp Thr Ile Trp Asn Glu Leu His Ser Ser Asn Ala Ala Arg Trp 
625                 630                 635                 640 


Ala Ala Gly Ser Val Thr Asp Leu Ala Phe Lys Val Ala Ser Arg Glu 
                645                 650                 655     


Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His Ala Asp 
            660                 665                 670         


His Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala Ile Ala 
        675                 680                 685             


Cys Arg Gln Leu Gln Gln Gln Ser Lys Ala Ser Lys Ile Leu Ile Val 
    690                 695                 700                 


Asp Trp Asp Val His His Gly Asn Gly Thr Gln Gln Thr Phe Tyr Gln 
705                 710                 715                 720 


Asp Pro Ser Val Leu Tyr Ile Ser Leu His Arg His Asp Asp Gly Asn 
                725                 730                 735     


Phe Phe Pro Gly Ser Gly Ala Val Asp Glu Val Gly Ala Gly Ser Gly 
            740                 745                 750         


Glu Gly Phe Asn Val Asn Val Ala Trp Ala Gly Gly Leu Asp Pro Pro 
        755                 760                 765             


Met Gly Asp Pro Glu Tyr Leu Ala Ala Phe Arg Ile Val Val Met Pro 
    770                 775                 780                 


Ile Ala Arg Glu Phe Ser Pro Asp Leu Val Leu Val Ser Ala Gly Phe 
785                 790                 795                 800 


Asp Ala Ala Glu Gly His Pro Ala Pro Leu Gly Gly Tyr His Val Ser 
                805                 810                 815     


Ala Lys Cys Phe Gly Tyr Met Thr Gln Gln Leu Met Asn Leu Ala Gly 
            820                 825                 830         


Gly Ala Val Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr Ala Ile 
        835                 840                 845             


Cys Asp Ala Ser Glu Ala Cys Val Ala Ala Leu Leu Gly Asn Arg Val 
    850                 855                 860                 


Asp Pro Leu Ser Glu Glu Gly Trp Lys Gln Lys Pro Asn Leu Asn Ala 
865                 870                 875                 880 


Ile Arg Ser Leu Glu Ala Val Ile Arg Val His Ser Lys Tyr Trp Gly 
                885                 890                 895     


Cys Met Gln Arg Leu Ala Ser Cys Pro Asp Ser Trp Val Pro Arg Val 
            900                 905                 910         


Pro Gly Ala Asp Lys Glu Glu Val Glu Ala Val Thr Ala Leu Ala Ser 
        915                 920                 925             


Leu Ser Val Gly Ile Leu Ala Glu Asp Arg Pro Ser Glu Gln Leu Val 
    930                 935                 940                 


Glu Glu Glu Glu Pro Met Asn Leu 
945                 950         


<210>  2970
<211>  4086
<212>  DNA
<213>  Homosapiens

<400>  2970
ataataccta ccttgcagga ccacgacagg attaagtgag gaaaaacccc catgagagtg     60

ttttgccatt gtcaagtgag cctgagggag gctgaggggg gatcaggctg tatcatgccc    120

ccgaggacaa actttccagt ttaccctgct ccctctctct gtccctaggc tgccccaggc    180

cctgtgcaga cacaccaggc cctcagccgc agcccatgga cctgcgggtg ggccagcggc    240

ccccagtgga gcccccacca gagcccacat tgctggccct gcagcgtccc cagcgcctgc    300

accaccacct cttcctagca ggcctgcagc agcagcgctc ggtggagccc atgaggctct    360

ccatggacac gccgatgccc gagttgcagg tgggacccca ggaacaagag ctgcggcagc    420

ttctccacaa ggacaagagc aagcgaagtg ctgtagccag cagcgtggtc aagcagaagc    480

tagcggaggt gattctgaaa aaacagcagg cggccctaga aagaacagtc catcccaaca    540

gccccggcat tccctacaga accctggagc ccctggagac ggaaggagcc acccgctcca    600

tgctcagcag ctttttgcct cctgttccca gcctgcccag tgacccccca gagcacttcc    660

ctctgcgcaa gacagtctct gagcccaacc tgaagctgcg ctataagccc aagaagtccc    720

tggagcggag gaagaatcca ctgctccgaa aggagagtgc gccccccagc ctccggcggc    780

ggcccgcaga gaccctcgga gactcctccc caagtagtag cagcacgccc gcatcagggt    840

gcagctcccc caatgacagc gagcacggcc ccaatcccat cctgggcgac agtgaccgca    900

ggacccatcc gactctgggc cctcgggggc caatcctggg gagcccccac actcccctct    960

tcctgcccca tggcttggag cccgaggctg ggggcacctt gccctctcgc ctgcagccca   1020

ttctcctcct ggacccctca ggctctcatg ccccgctgct gactgtgccc gggcttgggc   1080

ccttgccctt ccactttgcc cagtccttaa tgaccaccga gcggctctct gggtcaggcc   1140

tccactggcc actgagccgg actcgctcag agcccctgcc ccccagtgcc accgctcccc   1200

caccgccggg ccccatgcag ccccgcctgg agcagctcaa aactcacgtc caggtgatca   1260

agaggtcagc caagccgagt gagaagcccc ggctgcggca gataccctcg gctgaagacc   1320

tggagacaga tggcggggga ccgggccagg tggtggacga tggcctggag cacagggagc   1380

tgggccatgg gcagcctgag gccagaggcc ccgctcctct ccagcagcac cctcaggtgt   1440

tgctctggga acagcagcga ctggctgggc ggctcccccg gggcagcacc ggggacactg   1500

tgctgcttcc tctggcccag ggtgggcacc ggcctctgtc ccgggctcag tcttccccag   1560

ccgcacctgc ctcactgtca gccccagagc ctgccagcca ggcccgagtc ctctccagct   1620

cagagacccc tgccaggacc ctgcccttca ccacagggct gatctatgac tcggtcatgc   1680

tgaagcacca gtgctcctgc ggtgacaaca gcaggcaccc ggagcacgcc ggccgcatcc   1740

agagcatctg gtcccggctg caggagcggg ggctccggag ccagtgtgag tgtctccgag   1800

gccggaaggc ctccctggaa gagctgcagt cggtccactc tgagcggcac gtgctcctct   1860

acggcaccaa cccgctcagc cgcctcaaac tggacaacgg gaagctggca gggctcctgg   1920

cacagcggat gtttgtgatg ctgccctgtg gtggggttgg ggtggacact gacaccatct   1980

ggaatgagct tcattcctcc aatgcagccc gctgggccgc tggcagtgtc actgacctcg   2040

ccttcaaagt ggcttctcgt gagctaaaga atggtttcgc tgtggtgcgg cccccaggac   2100

accatgcaga tcattcaaca gccatgggct tctgcttctt caactcagtg gccatcgcct   2160

gccggcagct gcaacagcag agcaaggcca gcaagatcct cattgtagac tgggacgtgc   2220

accatggcaa cggcacccag caaaccttct accaagaccc cagtgtgctc tacatctccc   2280

tgcatcgcca tgacgacggc aacttcttcc cggggagtgg ggctgtggat gaggtagggg   2340

ctggcagcgg tgagggcttc aatgtcaatg tggcctgggc tggaggtctg gaccccccca   2400

tgggggatcc tgagtacctg gctgctttca ggatagtcgt gatgcccatc gcccgagagt   2460

tctctccaga cctagtcctg gtgtctgctg gatttgatgc tgctgagggt cacccggccc   2520

cactgggtgg ctaccatgtt tctgccaaat gttttggata catgacgcag caactgatga   2580

acctggcagg aggcgcagtg gtgctggcct tggagggtgg ccatgacctc acagccatct   2640

gtgacgcctc tgaggcctgt gtggctgctc ttctgggtaa cagggtggat cccctttcag   2700

aagaaggctg gaaacagaaa cccaacctca atgccatccg ctctctggag gccgtgatcc   2760

gggtgcacag taaatactgg ggctgcatgc agcgcctggc ctcctgtcca gactcctggg   2820

tgcctagagt gccaggggct gacaaagaag aagtggaggc agtgaccgca ctggcgtccc   2880

tctctgtggg catcctggct gaagataggc cctcggagca gctggtggag gaggaagaac   2940

ctatgaatct ctaaggctct ggaaccatct gcccgcccac catgcccttg ggacctggtt   3000

ctcttctaac ccctggcaat agcccccatt cctgggtctt tagagatcct gtgggcaagt   3060

agttggaacc agagaacagc ctgcctgctt tgacagttat cccagggagc gtgagaaaat   3120

ccctgggtct agaatgggaa ctggagagga ccctgagagg agacgggctg ggcggcgacc   3180

cccacagggc tctcgagaac agattctccc ctccagtatg ggccctggct gtggccccca   3240

ttcctcagga ctgcacagag gaggactggc tccggctccg tcgggctcac ccttaaccac   3300

tattcctggc tctgcaaacc ccagactttg cacacagccc caggctccac acagaaatgt   3360

gaacttggcc tcagacaggc tggcccttcc taggctctag gggctagggg ggagtgggga   3420

gccaagaggt cccatattcc tgagtgcagg ggtagtccct ctcacctgct tcctcagacg   3480

actctggaag cttccctcta ccaccgggca ctgagacgaa gctccctgac agccgagact   3540

ggcagccctc catctggtcc gtaccctcgc cagaggcccc cctacatcaa cctcctggcg   3600

atgccctggt ggagcagatg ggtgctctgg gagtcctgtg cttcctgatc caatggtgcc   3660

aaacccttca tctcccccag aagcgcagca tacccctggg acccctcggc cactgcccac   3720

tcggggagcc ttctctgttt ctggggcctc ccccaccata gctctgattc ccaccccaca   3780

taggaatagc ctgactgagg gggaaggggt gggagagaag atacagacat ggaggagggg   3840

aggctgctct ggcaaagtct tcaaggcttt tgggggtcca ggcctggggt caagaaggaa   3900

aatgtgtgtg agcatgtgtg tgagtgaggc gtgtgtgtga gcgtgtgtgt gagtgaggcg   3960

tgtgtgtgtg tctttcctag gacccaccat accctgtgta tgtatgcatg tttttgtaaa   4020

aaggaagaaa atggaaaaaa atctgaacaa taaatgtttt atttgcttta aaaaaaaaaa   4080

aaaaaa                                                              4086


<210>  2971
<211>  912
<212>  PRT
<213>  Homosapiens

<400>  2971

Met Asp Leu Arg Val Gly Gln Arg Pro Pro Val Glu Pro Pro Pro Glu 
1               5                   10                  15      


Pro Thr Leu Leu Ala Leu Gln Arg Pro Gln Arg Leu His His His Leu 
            20                  25                  30          


Phe Leu Ala Gly Leu Gln Gln Gln Arg Ser Val Glu Pro Met Arg Leu 
        35                  40                  45              


Ser Met Asp Thr Pro Met Pro Glu Leu Gln Val Gly Pro Gln Glu Gln 
    50                  55                  60                  


Glu Leu Arg Gln Leu Leu His Lys Asp Lys Ser Lys Arg Ser Ala Val 
65                  70                  75                  80  


Ala Ser Ser Val Val Lys Gln Lys Leu Ala Glu Val Ile Leu Lys Lys 
                85                  90                  95      


Gln Gln Ala Ala Leu Glu Arg Thr Val His Pro Asn Ser Pro Gly Ile 
            100                 105                 110         


Pro Tyr Arg Thr Leu Glu Pro Leu Glu Thr Glu Gly Ala Thr Arg Ser 
        115                 120                 125             


Met Leu Ser Ser Phe Leu Pro Pro Val Pro Ser Leu Pro Ser Asp Pro 
    130                 135                 140                 


Pro Glu His Phe Pro Leu Arg Lys Thr Val Ser Glu Pro Asn Leu Lys 
145                 150                 155                 160 


Leu Arg Tyr Lys Pro Lys Lys Ser Leu Glu Arg Arg Lys Asn Pro Leu 
                165                 170                 175     


Leu Arg Lys Glu Ser Ala Pro Pro Ser Leu Arg Arg Arg Pro Ala Glu 
            180                 185                 190         


Thr Leu Gly Asp Ser Ser Pro Ser Ser Ser Ser Thr Pro Ala Ser Gly 
        195                 200                 205             


Cys Ser Ser Pro Asn Asp Ser Glu His Gly Pro Asn Pro Ile Leu Gly 
    210                 215                 220                 


Asp Ser Asp Arg Arg Thr His Pro Thr Leu Gly Pro Arg Gly Pro Ile 
225                 230                 235                 240 


Leu Gly Ser Pro His Thr Pro Leu Phe Leu Pro His Gly Leu Glu Pro 
                245                 250                 255     


Glu Ala Gly Gly Thr Leu Pro Ser Arg Leu Gln Pro Ile Leu Leu Leu 
            260                 265                 270         


Asp Pro Ser Gly Ser His Ala Pro Leu Leu Thr Val Pro Gly Leu Gly 
        275                 280                 285             


Pro Leu Pro Phe His Phe Ala Gln Ser Leu Met Thr Thr Glu Arg Leu 
    290                 295                 300                 


Ser Gly Ser Gly Leu His Trp Pro Leu Ser Arg Thr Arg Ser Glu Pro 
305                 310                 315                 320 


Leu Pro Pro Ser Ala Thr Ala Pro Pro Pro Pro Gly Pro Met Gln Pro 
                325                 330                 335     


Arg Leu Glu Gln Leu Lys Thr His Val Gln Val Ile Lys Arg Ser Ala 
            340                 345                 350         


Lys Pro Ser Glu Lys Pro Arg Leu Arg Gln Ile Pro Ser Ala Glu Asp 
        355                 360                 365             


Leu Glu Thr Asp Gly Gly Gly Pro Gly Gln Val Val Asp Asp Gly Leu 
    370                 375                 380                 


Glu His Arg Glu Leu Gly His Gly Gln Pro Glu Ala Arg Gly Pro Ala 
385                 390                 395                 400 


Pro Leu Gln Gln His Pro Gln Val Leu Leu Trp Glu Gln Gln Arg Leu 
                405                 410                 415     


Ala Gly Arg Leu Pro Arg Gly Ser Thr Gly Asp Thr Val Leu Leu Pro 
            420                 425                 430         


Leu Ala Gln Gly Gly His Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro 
        435                 440                 445             


Ala Ala Pro Ala Ser Leu Ser Ala Pro Glu Pro Ala Ser Gln Ala Arg 
    450                 455                 460                 


Val Leu Ser Ser Ser Glu Thr Pro Ala Arg Thr Leu Pro Phe Thr Thr 
465                 470                 475                 480 


Gly Leu Ile Tyr Asp Ser Val Met Leu Lys His Gln Cys Ser Cys Gly 
                485                 490                 495     


Asp Asn Ser Arg His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp 
            500                 505                 510         


Ser Arg Leu Gln Glu Arg Gly Leu Arg Ser Gln Cys Glu Cys Leu Arg 
        515                 520                 525             


Gly Arg Lys Ala Ser Leu Glu Glu Leu Gln Ser Val His Ser Glu Arg 
    530                 535                 540                 


His Val Leu Leu Tyr Gly Thr Asn Pro Leu Ser Arg Leu Lys Leu Asp 
545                 550                 555                 560 


Asn Gly Lys Leu Ala Gly Leu Leu Ala Gln Arg Met Phe Val Met Leu 
                565                 570                 575     


Pro Cys Gly Gly Val Gly Val Asp Thr Asp Thr Ile Trp Asn Glu Leu 
            580                 585                 590         


His Ser Ser Asn Ala Ala Arg Trp Ala Ala Gly Ser Val Thr Asp Leu 
        595                 600                 605             


Ala Phe Lys Val Ala Ser Arg Glu Leu Lys Asn Gly Phe Ala Val Val 
    610                 615                 620                 


Arg Pro Pro Gly His His Ala Asp His Ser Thr Ala Met Gly Phe Cys 
625                 630                 635                 640 


Phe Phe Asn Ser Val Ala Ile Ala Cys Arg Gln Leu Gln Gln Gln Ser 
                645                 650                 655     


Lys Ala Ser Lys Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn 
            660                 665                 670         


Gly Thr Gln Gln Thr Phe Tyr Gln Asp Pro Ser Val Leu Tyr Ile Ser 
        675                 680                 685             


Leu His Arg His Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala Val 
    690                 695                 700                 


Asp Glu Val Gly Ala Gly Ser Gly Glu Gly Phe Asn Val Asn Val Ala 
705                 710                 715                 720 


Trp Ala Gly Gly Leu Asp Pro Pro Met Gly Asp Pro Glu Tyr Leu Ala 
                725                 730                 735     


Ala Phe Arg Ile Val Val Met Pro Ile Ala Arg Glu Phe Ser Pro Asp 
            740                 745                 750         


Leu Val Leu Val Ser Ala Gly Phe Asp Ala Ala Glu Gly His Pro Ala 
        755                 760                 765             


Pro Leu Gly Gly Tyr His Val Ser Ala Lys Cys Phe Gly Tyr Met Thr 
    770                 775                 780                 


Gln Gln Leu Met Asn Leu Ala Gly Gly Ala Val Val Leu Ala Leu Glu 
785                 790                 795                 800 


Gly Gly His Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val 
                805                 810                 815     


Ala Ala Leu Leu Gly Asn Arg Val Asp Pro Leu Ser Glu Glu Gly Trp 
            820                 825                 830         


Lys Gln Lys Pro Asn Leu Asn Ala Ile Arg Ser Leu Glu Ala Val Ile 
        835                 840                 845             


Arg Val His Ser Lys Tyr Trp Gly Cys Met Gln Arg Leu Ala Ser Cys 
    850                 855                 860                 


Pro Asp Ser Trp Val Pro Arg Val Pro Gly Ala Asp Lys Glu Glu Val 
865                 870                 875                 880 


Glu Ala Val Thr Ala Leu Ala Ser Leu Ser Val Gly Ile Leu Ala Glu 
                885                 890                 895     


Asp Arg Pro Ser Glu Gln Leu Val Glu Glu Glu Glu Pro Met Asn Leu 
            900                 905                 910         


<210>  2972
<211>  4669
<212>  DNA
<213>  Homosapiens

<400>  2972
ctgcttgtca aaaggcggca gcggagccgt gtgcgccggg agcgcggaac agcttgtcca     60

cccgccggcc ggaccagaag cctttgggtc tgaagtgtct gtgagacctc acagaagagc    120

acccctgggc tccacttacc tgccccctgc tccttcaggg atggaggcaa tggcggccag    180

cacttccctg cctgaccctg gagactttga ccggaacgtg ccccggatct gtggggtgtg    240

tggagaccga gccactggct ttcacttcaa tgctatgacc tgtgaaggct gcaaaggctt    300

cttcaggcga agcatgaagc ggaaggcact attcacctgc cccttcaacg gggactgccg    360

catcaccaag gacaaccgac gccactgcca ggcctgccgg ctcaaacgct gtgtggacat    420

cggcatgatg aaggagttca ttctgacaga tgaggaagtg cagaggaagc gggagatgat    480

cctgaagcgg aaggaggagg aggccttgaa ggacagtctg cggcccaagc tgtctgagga    540

gcagcagcgc atcattgcca tactgctgga cgcccaccat aagacctacg accccaccta    600

ctccgacttc tgccagttcc ggcctccagt tcgtgtgaat gatggtggag ggagccatcc    660

ttccaggccc aactccagac acactcccag cttctctggg gactcctcct cctcctgctc    720

agatcactgt atcacctctt cagacatgat ggactcgtcc agcttctcca atctggatct    780

gagtgaagaa gattcagatg acccttctgt gaccctagag ctgtcccagc tctccatgct    840

gccccacctg gctgacctgg tcagttacag catccaaaag gtcattggct ttgctaagat    900

gataccagga ttcagagacc tcacctctga ggaccagatc gtactgctga agtcaagtgc    960

cattgaggtc atcatgttgc gctccaatga gtccttcacc atggacgaca tgtcctggac   1020

ctgtggcaac caagactaca agtaccgcgt cagtgacgtg accaaagccg gacacagcct   1080

ggagctgatt gagcccctca tcaagttcca ggtgggactg aagaagctga acttgcatga   1140

ggaggagcat gtcctgctca tggccatctg catcgtctcc ccagatcgtc ctggggtgca   1200

ggacgccgcg ctgattgagg ccatccagga ccgcctgtcc aacacactgc agacgtacat   1260

ccgctgccgc cacccgcccc cgggcagcca cctgctctat gccaagatga tccagaagct   1320

agccgacctg cgcagcctca atgaggagca ctccaagcag taccgctgcc tctccttcca   1380

gcctgagtgc agcatgaagc taacgcccct tgtgctcgaa gtgtttggca atgagatctc   1440

ctgactagga cagcctgtgg cggtgcctgg gtggggctgc tcctccaggg ccacgtgcca   1500

ggcccggggc tggcggctac tcagcagccc tcctcacccc gtctggggtt cagcccctcc   1560

tctgccacct cccctatcca cccagcccat tctctctcct gtccaaccta acccctttcc   1620

tgcgggcttt tccccggtcc cttgagacct cagccatgag gagttgctgt ttgtttgaca   1680

aagaaaccca agtgggggca gagggcagag gctggaggca gggccttgcc cagagatgcc   1740

tccaccgctg cctaagtggc tgctgactga tgttgaggga acagacagga gaaatgcatc   1800

cattcctcag ggacagagac acctgcacct ccccccactg caggccccgc ttgtccagcg   1860

cctagtgggg tctccctctc ctgcctactc acgataaata atcggcccac agctcccacc   1920

ccaccccctt cagtgcccac caacatccca ttgccctggt tatattctca cgggcagtag   1980

ctgtggtgag gtgggttttc ttcccatcac tggagcacca ggcacgaacc cacctgctga   2040

gagacccaag gaggaaaaac agacaaaaac agcctcacag aagaatatga cagctgtccc   2100

tgtcaccaag ctcacagttc ctcgccctgg gtctaagggg ttggttgagg tggaagccct   2160

ccttccacgg atccatgtag caggactgaa ttgtccccag tttgcagaaa agcacctgcc   2220

gacctcgtcc tccccctgcc agtgccttac ctcctgccca ggagagccag ccctccctgt   2280

cctcctcgga tcaccgagag tagccgagag cctgctcccc caccccctcc ccaggggaga   2340

gggtctggag aagcagtgag ccgcatcttc tccatctggc agggtgggat ggaggagaag   2400

aattttcaga ccccagcggc tgagtcatga tctccctgcc gcctcaatgt ggttgcaagg   2460

ccgctgttca cccacagggc taagagctag cgctgccgca ccccagagtg tgggaaggga   2520

gagcggggca gtctcgggtg gctagtcaga gagagtgttt gggggttccg tgatgtaggg   2580

taaggtgcct tcttattctc actccaccac ccaaaagtca aaaggtgcct gtgaggcagg   2640

ggcggagtga tacaacttca agtgcatgct ctctgcagcc agcccagccc agctggtggg   2700

aagcgtctgt ccgtttactc caaggtgggg tctttgtgag agtgagctgt aggtgtgcgg   2760

gaccggtaca gaaaggcgtt cttcgaggtg gatcacagag gcttcttcag atcagtgctt   2820

gagtttgggg aatgcggccg cattccctga gtcaccagga atgttaaagt cagtgggaac   2880

gtgactgccc caactcctgg aagctgtgtc cttgcacctg catccgtagt tccctgaaaa   2940

cccagagagg aatcagactt cacactgcaa gagccttggt gtccacctgg ccccatgtct   3000

ctcagaattc ttcaggtgga aaaacatctg aaagccacgt tccttactgc agaatagcat   3060

atatatcgct taatcttaaa tttattagat atgagttgtt ttcagactca gactccattt   3120

gtattatagt ctaatataca gggtagcagg taccactgat ttggagatat ttatgggggg   3180

agaacttaca ttgtgaaact tctgtacatt aattattatt gctgttgtta ttttacaagg   3240

gtctagggag agacccttgt ttgattttag ctgcagaacg tattggtcca gcttgctctt   3300

cagtgggaga aaacacttgt aagttgctaa acgagtcaat cccctcattc aggaaaactg   3360

acagaggagg gcgtgactca cccaagcata tataactagc tagaagtggg ccaggacagg   3420

cccggcgcgg tggctcacgc ctgtaatccc agcagtttgg gaggtcgagg taggtggatc   3480

acctgaggtc gggagttcga gaccaacctg accaacatgg agaaaccctg tctctattaa   3540

aaatacaaaa aaaaaaaaaa aaaaaatagc cgggcatggt ggcgcaagcc tgtaatccca   3600

gctactcagg aggctgaggc agaagaattg aacccaggag gtggaggttg cagtgagctg   3660

agatcgtgcc gttactctcc aacctggaca acaagagcga aactccgtct tagaagtgga   3720

ccaggacagg accagatttt ggagtcatgg tccggtgtcc ttttcactac accatgtttg   3780

agctcagacc cccactctca ttccccaggt ggctgaccca gtccctgggg gaagccctgg   3840

atttcagaaa gagcaagtct ggatctggga ccctttcctt ccttccctgg cttgtaactc   3900

caccaaccca tcagaaggag aaggaaggag actcacctct gcctcaatgt gaatcagacc   3960

ctaccccacc acgatgtggc cctggcctgc tgggctctcc acctcagcct tggataatgc   4020

tgttgcctca tctataacat gcatttgtct ttgtaatgtc accaccttcc cagctctccc   4080

tctggccctg ccttcttcgg ggaactcctg gaaatatcag ttactcagcc ctgggcccca   4140

ccacctaggc cactcctcca aaggaagtct aggagctggg aggaaaagaa aagaggggaa   4200

aatgagtttt tatggggctg aacggggaga aaaggtcatc atcgattcta ctttagaatg   4260

agagtgtgaa atagacattt gtaaatgtaa aacttttaag gtatatcatt ataactgaag   4320

gagaaggtgc cccaaaatgc aagattttcc acaagattcc cagagacagg aaaatcctct   4380

ggctggctaa ctggaagcat gtaggagaat ccaagcgagg tcaacagaga aggcaggaat   4440

gtgtggcaga tttagtgaaa gctagagata tggcagcgaa aggatgtaaa cagtgcctgc   4500

tgaatgattt ccaaagagaa aaaaagtttg ccagaagttt gtcaagtcaa ccaatgtaga   4560

aagctttgct tatggtaata aaaatggctc atacttatat agcacttact ttgttgcaag   4620

tactgctgta aataaatgct ttatgcaaac caaaaaaaaa aaaaaaaaa               4669


<210>  2973
<211>  427
<212>  PRT
<213>  Homosapiens

<400>  2973

Met Glu Ala Met Ala Ala Ser Thr Ser Leu Pro Asp Pro Gly Asp Phe 
1               5                   10                  15      


Asp Arg Asn Val Pro Arg Ile Cys Gly Val Cys Gly Asp Arg Ala Thr 
            20                  25                  30          


Gly Phe His Phe Asn Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe 
        35                  40                  45              


Arg Arg Ser Met Lys Arg Lys Ala Leu Phe Thr Cys Pro Phe Asn Gly 
    50                  55                  60                  


Asp Cys Arg Ile Thr Lys Asp Asn Arg Arg His Cys Gln Ala Cys Arg 
65                  70                  75                  80  


Leu Lys Arg Cys Val Asp Ile Gly Met Met Lys Glu Phe Ile Leu Thr 
                85                  90                  95      


Asp Glu Glu Val Gln Arg Lys Arg Glu Met Ile Leu Lys Arg Lys Glu 
            100                 105                 110         


Glu Glu Ala Leu Lys Asp Ser Leu Arg Pro Lys Leu Ser Glu Glu Gln 
        115                 120                 125             


Gln Arg Ile Ile Ala Ile Leu Leu Asp Ala His His Lys Thr Tyr Asp 
    130                 135                 140                 


Pro Thr Tyr Ser Asp Phe Cys Gln Phe Arg Pro Pro Val Arg Val Asn 
145                 150                 155                 160 


Asp Gly Gly Gly Ser His Pro Ser Arg Pro Asn Ser Arg His Thr Pro 
                165                 170                 175     


Ser Phe Ser Gly Asp Ser Ser Ser Ser Cys Ser Asp His Cys Ile Thr 
            180                 185                 190         


Ser Ser Asp Met Met Asp Ser Ser Ser Phe Ser Asn Leu Asp Leu Ser 
        195                 200                 205             


Glu Glu Asp Ser Asp Asp Pro Ser Val Thr Leu Glu Leu Ser Gln Leu 
    210                 215                 220                 


Ser Met Leu Pro His Leu Ala Asp Leu Val Ser Tyr Ser Ile Gln Lys 
225                 230                 235                 240 


Val Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Arg Asp Leu Thr Ser 
                245                 250                 255     


Glu Asp Gln Ile Val Leu Leu Lys Ser Ser Ala Ile Glu Val Ile Met 
            260                 265                 270         


Leu Arg Ser Asn Glu Ser Phe Thr Met Asp Asp Met Ser Trp Thr Cys 
        275                 280                 285             


Gly Asn Gln Asp Tyr Lys Tyr Arg Val Ser Asp Val Thr Lys Ala Gly 
    290                 295                 300                 


His Ser Leu Glu Leu Ile Glu Pro Leu Ile Lys Phe Gln Val Gly Leu 
305                 310                 315                 320 


Lys Lys Leu Asn Leu His Glu Glu Glu His Val Leu Leu Met Ala Ile 
                325                 330                 335     


Cys Ile Val Ser Pro Asp Arg Pro Gly Val Gln Asp Ala Ala Leu Ile 
            340                 345                 350         


Glu Ala Ile Gln Asp Arg Leu Ser Asn Thr Leu Gln Thr Tyr Ile Arg 
        355                 360                 365             


Cys Arg His Pro Pro Pro Gly Ser His Leu Leu Tyr Ala Lys Met Ile 
    370                 375                 380                 


Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn Glu Glu His Ser Lys Gln 
385                 390                 395                 400 


Tyr Arg Cys Leu Ser Phe Gln Pro Glu Cys Ser Met Lys Leu Thr Pro 
                405                 410                 415     


Leu Val Leu Glu Val Phe Gly Asn Glu Ile Ser 
            420                 425         


<210>  2974
<211>  4791
<212>  DNA
<213>  Homosapiens

<400>  2974
ctgcttgtca aaaggcggca gcggagccgt gtgcgccggg agcgcggaac agcttgtcca     60

cccgccggcc ggaccagggc tcctgaacct agcccagctg gacggagaaa tggactctag    120

cctcctctga tagcctcatg ccaggccccg tgcacattgc tttgcttgcc tccctcaatc    180

ctcatagctt ctctttggga agcctttggg tctgaagtgt ctgtgagacc tcacagaaga    240

gcacccctgg gctccactta cctgccccct gctccttcag ggatggaggc aatggcggcc    300

agcacttccc tgcctgaccc tggagacttt gaccggaacg tgccccggat ctgtggggtg    360

tgtggagacc gagccactgg ctttcacttc aatgctatga cctgtgaagg ctgcaaaggc    420

ttcttcaggc gaagcatgaa gcggaaggca ctattcacct gccccttcaa cggggactgc    480

cgcatcacca aggacaaccg acgccactgc caggcctgcc ggctcaaacg ctgtgtggac    540

atcggcatga tgaaggagtt cattctgaca gatgaggaag tgcagaggaa gcgggagatg    600

atcctgaagc ggaaggagga ggaggccttg aaggacagtc tgcggcccaa gctgtctgag    660

gagcagcagc gcatcattgc catactgctg gacgcccacc ataagaccta cgaccccacc    720

tactccgact tctgccagtt ccggcctcca gttcgtgtga atgatggtgg agggagccat    780

ccttccaggc ccaactccag acacactccc agcttctctg gggactcctc ctcctcctgc    840

tcagatcact gtatcacctc ttcagacatg atggactcgt ccagcttctc caatctggat    900

ctgagtgaag aagattcaga tgacccttct gtgaccctag agctgtccca gctctccatg    960

ctgccccacc tggctgacct ggtcagttac agcatccaaa aggtcattgg ctttgctaag   1020

atgataccag gattcagaga cctcacctct gaggaccaga tcgtactgct gaagtcaagt   1080

gccattgagg tcatcatgtt gcgctccaat gagtccttca ccatggacga catgtcctgg   1140

acctgtggca accaagacta caagtaccgc gtcagtgacg tgaccaaagc cggacacagc   1200

ctggagctga ttgagcccct catcaagttc caggtgggac tgaagaagct gaacttgcat   1260

gaggaggagc atgtcctgct catggccatc tgcatcgtct ccccagatcg tcctggggtg   1320

caggacgccg cgctgattga ggccatccag gaccgcctgt ccaacacact gcagacgtac   1380

atccgctgcc gccacccgcc cccgggcagc cacctgctct atgccaagat gatccagaag   1440

ctagccgacc tgcgcagcct caatgaggag cactccaagc agtaccgctg cctctccttc   1500

cagcctgagt gcagcatgaa gctaacgccc cttgtgctcg aagtgtttgg caatgagatc   1560

tcctgactag gacagcctgt ggcggtgcct gggtggggct gctcctccag ggccacgtgc   1620

caggcccggg gctggcggct actcagcagc cctcctcacc ccgtctgggg ttcagcccct   1680

cctctgccac ctcccctatc cacccagccc attctctctc ctgtccaacc taaccccttt   1740

cctgcgggct tttccccggt cccttgagac ctcagccatg aggagttgct gtttgtttga   1800

caaagaaacc caagtggggg cagagggcag aggctggagg cagggccttg cccagagatg   1860

cctccaccgc tgcctaagtg gctgctgact gatgttgagg gaacagacag gagaaatgca   1920

tccattcctc agggacagag acacctgcac ctccccccac tgcaggcccc gcttgtccag   1980

cgcctagtgg ggtctccctc tcctgcctac tcacgataaa taatcggccc acagctccca   2040

ccccaccccc ttcagtgccc accaacatcc cattgccctg gttatattct cacgggcagt   2100

agctgtggtg aggtgggttt tcttcccatc actggagcac caggcacgaa cccacctgct   2160

gagagaccca aggaggaaaa acagacaaaa acagcctcac agaagaatat gacagctgtc   2220

cctgtcacca agctcacagt tcctcgccct gggtctaagg ggttggttga ggtggaagcc   2280

ctccttccac ggatccatgt agcaggactg aattgtcccc agtttgcaga aaagcacctg   2340

ccgacctcgt cctccccctg ccagtgcctt acctcctgcc caggagagcc agccctccct   2400

gtcctcctcg gatcaccgag agtagccgag agcctgctcc cccaccccct ccccagggga   2460

gagggtctgg agaagcagtg agccgcatct tctccatctg gcagggtggg atggaggaga   2520

agaattttca gaccccagcg gctgagtcat gatctccctg ccgcctcaat gtggttgcaa   2580

ggccgctgtt cacccacagg gctaagagct agcgctgccg caccccagag tgtgggaagg   2640

gagagcgggg cagtctcggg tggctagtca gagagagtgt ttgggggttc cgtgatgtag   2700

ggtaaggtgc cttcttattc tcactccacc acccaaaagt caaaaggtgc ctgtgaggca   2760

ggggcggagt gatacaactt caagtgcatg ctctctgcag ccagcccagc ccagctggtg   2820

ggaagcgtct gtccgtttac tccaaggtgg ggtctttgtg agagtgagct gtaggtgtgc   2880

gggaccggta cagaaaggcg ttcttcgagg tggatcacag aggcttcttc agatcagtgc   2940

ttgagtttgg ggaatgcggc cgcattccct gagtcaccag gaatgttaaa gtcagtggga   3000

acgtgactgc cccaactcct ggaagctgtg tccttgcacc tgcatccgta gttccctgaa   3060

aacccagaga ggaatcagac ttcacactgc aagagccttg gtgtccacct ggccccatgt   3120

ctctcagaat tcttcaggtg gaaaaacatc tgaaagccac gttccttact gcagaatagc   3180

atatatatcg cttaatctta aatttattag atatgagttg ttttcagact cagactccat   3240

ttgtattata gtctaatata cagggtagca ggtaccactg atttggagat atttatgggg   3300

ggagaactta cattgtgaaa cttctgtaca ttaattatta ttgctgttgt tattttacaa   3360

gggtctaggg agagaccctt gtttgatttt agctgcagaa cgtattggtc cagcttgctc   3420

ttcagtggga gaaaacactt gtaagttgct aaacgagtca atcccctcat tcaggaaaac   3480

tgacagagga gggcgtgact cacccaagca tatataacta gctagaagtg ggccaggaca   3540

ggcccggcgc ggtggctcac gcctgtaatc ccagcagttt gggaggtcga ggtaggtgga   3600

tcacctgagg tcgggagttc gagaccaacc tgaccaacat ggagaaaccc tgtctctatt   3660

aaaaatacaa aaaaaaaaaa aaaaaaaata gccgggcatg gtggcgcaag cctgtaatcc   3720

cagctactca ggaggctgag gcagaagaat tgaacccagg aggtggaggt tgcagtgagc   3780

tgagatcgtg ccgttactct ccaacctgga caacaagagc gaaactccgt cttagaagtg   3840

gaccaggaca ggaccagatt ttggagtcat ggtccggtgt ccttttcact acaccatgtt   3900

tgagctcaga cccccactct cattccccag gtggctgacc cagtccctgg gggaagccct   3960

ggatttcaga aagagcaagt ctggatctgg gaccctttcc ttccttccct ggcttgtaac   4020

tccaccaacc catcagaagg agaaggaagg agactcacct ctgcctcaat gtgaatcaga   4080

ccctacccca ccacgatgtg gccctggcct gctgggctct ccacctcagc cttggataat   4140

gctgttgcct catctataac atgcatttgt ctttgtaatg tcaccacctt cccagctctc   4200

cctctggccc tgccttcttc ggggaactcc tggaaatatc agttactcag ccctgggccc   4260

caccacctag gccactcctc caaaggaagt ctaggagctg ggaggaaaag aaaagagggg   4320

aaaatgagtt tttatggggc tgaacgggga gaaaaggtca tcatcgattc tactttagaa   4380

tgagagtgtg aaatagacat ttgtaaatgt aaaactttta aggtatatca ttataactga   4440

aggagaaggt gccccaaaat gcaagatttt ccacaagatt cccagagaca ggaaaatcct   4500

ctggctggct aactggaagc atgtaggaga atccaagcga ggtcaacaga gaaggcagga   4560

atgtgtggca gatttagtga aagctagaga tatggcagcg aaaggatgta aacagtgcct   4620

gctgaatgat ttccaaagag aaaaaaagtt tgccagaagt ttgtcaagtc aaccaatgta   4680

gaaagctttg cttatggtaa taaaaatggc tcatacttat atagcactta ctttgttgca   4740

agtactgctg taaataaatg ctttatgcaa accaaaaaaa aaaaaaaaaa a            4791


<210>  2975
<211>  427
<212>  PRT
<213>  Homosapiens

<400>  2975

Met Glu Ala Met Ala Ala Ser Thr Ser Leu Pro Asp Pro Gly Asp Phe 
1               5                   10                  15      


Asp Arg Asn Val Pro Arg Ile Cys Gly Val Cys Gly Asp Arg Ala Thr 
            20                  25                  30          


Gly Phe His Phe Asn Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe 
        35                  40                  45              


Arg Arg Ser Met Lys Arg Lys Ala Leu Phe Thr Cys Pro Phe Asn Gly 
    50                  55                  60                  


Asp Cys Arg Ile Thr Lys Asp Asn Arg Arg His Cys Gln Ala Cys Arg 
65                  70                  75                  80  


Leu Lys Arg Cys Val Asp Ile Gly Met Met Lys Glu Phe Ile Leu Thr 
                85                  90                  95      


Asp Glu Glu Val Gln Arg Lys Arg Glu Met Ile Leu Lys Arg Lys Glu 
            100                 105                 110         


Glu Glu Ala Leu Lys Asp Ser Leu Arg Pro Lys Leu Ser Glu Glu Gln 
        115                 120                 125             


Gln Arg Ile Ile Ala Ile Leu Leu Asp Ala His His Lys Thr Tyr Asp 
    130                 135                 140                 


Pro Thr Tyr Ser Asp Phe Cys Gln Phe Arg Pro Pro Val Arg Val Asn 
145                 150                 155                 160 


Asp Gly Gly Gly Ser His Pro Ser Arg Pro Asn Ser Arg His Thr Pro 
                165                 170                 175     


Ser Phe Ser Gly Asp Ser Ser Ser Ser Cys Ser Asp His Cys Ile Thr 
            180                 185                 190         


Ser Ser Asp Met Met Asp Ser Ser Ser Phe Ser Asn Leu Asp Leu Ser 
        195                 200                 205             


Glu Glu Asp Ser Asp Asp Pro Ser Val Thr Leu Glu Leu Ser Gln Leu 
    210                 215                 220                 


Ser Met Leu Pro His Leu Ala Asp Leu Val Ser Tyr Ser Ile Gln Lys 
225                 230                 235                 240 


Val Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Arg Asp Leu Thr Ser 
                245                 250                 255     


Glu Asp Gln Ile Val Leu Leu Lys Ser Ser Ala Ile Glu Val Ile Met 
            260                 265                 270         


Leu Arg Ser Asn Glu Ser Phe Thr Met Asp Asp Met Ser Trp Thr Cys 
        275                 280                 285             


Gly Asn Gln Asp Tyr Lys Tyr Arg Val Ser Asp Val Thr Lys Ala Gly 
    290                 295                 300                 


His Ser Leu Glu Leu Ile Glu Pro Leu Ile Lys Phe Gln Val Gly Leu 
305                 310                 315                 320 


Lys Lys Leu Asn Leu His Glu Glu Glu His Val Leu Leu Met Ala Ile 
                325                 330                 335     


Cys Ile Val Ser Pro Asp Arg Pro Gly Val Gln Asp Ala Ala Leu Ile 
            340                 345                 350         


Glu Ala Ile Gln Asp Arg Leu Ser Asn Thr Leu Gln Thr Tyr Ile Arg 
        355                 360                 365             


Cys Arg His Pro Pro Pro Gly Ser His Leu Leu Tyr Ala Lys Met Ile 
    370                 375                 380                 


Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn Glu Glu His Ser Lys Gln 
385                 390                 395                 400 


Tyr Arg Cys Leu Ser Phe Gln Pro Glu Cys Ser Met Lys Leu Thr Pro 
                405                 410                 415     


Leu Val Leu Glu Val Phe Gly Asn Glu Ile Ser 
            420                 425         


<210>  2976
<211>  1449
<212>  DNA
<213>  Homosapiens

<400>  2976
gacatgacac cagtggcata tcacggccat ggggtctcag cattccgctg ctgctcgccc     60

ctcctcctgc aggcgaaagc aagaagatga cagggacggt ttgctggctg aacgagagca    120

ggaagaagcc attgctcagt tcccatatgt ggaattcacc gggagagata gcatcacctg    180

tctcacgtgc caggggacag gctacattcc aacagagcaa gtaaatgagt tggtggcttt    240

gatcccacac agtgatcaga gattgcgccc tcagcgaact aagcaatatg tcctcctgtc    300

catcctgctt tgtctcctgg catctggttt ggtggttttc ttcctgtttc cgcattcagt    360

ccttgtggat gatgacggca tcaaagtggt gaaagtcaca tttaataagc aagactccct    420

tgtaattctc accatcatgg ccaccctgaa aatcaggaac tccaacttct acacggtggc    480

agtgaccagc ctgtccagcc agattcagta catgaacaca gtggtcagta catatgtgac    540

tactaacgtc tcccttattc cacctcggag tgagcaactg gtgaatttta ccgggaaggc    600

cgagatggga ggaccgtttt cctatgtgta cttcttctgc acggtacctg agatcctggt    660

gcacaacata gtgatcttca tgcgaacttc agtgaagatt tcatacattg gcctcatgac    720

ccagagctcc ttggagacac atcactatgt ggattgtgga ggaaattcca cagctattta    780

acaactgcta ttggttcttc cacacagcgc ctgtagaaga gagcacagca tatgttccca    840

aggcctgagt tctggaccta cccccacgtg gtgtaagcag aggaggaatt ggttcactta    900

actcccagca aacatcctcc tgccacttag gaggaaacac ctccctatgg taccatttat    960

gtttctcaga accagcagaa tcagtgccta gcctgtgccc agcaaatagt tggcactcaa   1020

taaagatttg cagaatttaa tacagatctt ttcagctgtt cttagggcat tataaatgga   1080

aatcataacg tggttctagg ttatcaaacc atggagtgat gtggagctag gattgtgagt   1140

gacctgcagg ccattatcag tgcctcatct gtgcagaagt ggcagcagag agggaccatc   1200

caaataccta agagaaaaca gacctagtca ggatatgaat ttgtttcagc tgttcccaaa   1260

ggcctgggag ctttttgaaa agaaagaaaa aagtgtgttg gctttttttt ttttttagaa   1320

agttagaatt gtttttacca agagtctatg tggggcttga ttcacccttc atccattggc   1380

tggaacatgg attggggatt tgatagaaaa ataaaccctg cttttgattc aaaaaaaaaa   1440

aaaaaaaaa                                                           1449


<210>  2977
<211>  250
<212>  PRT
<213>  Homosapiens

<400>  2977

Met Gly Ser Gln His Ser Ala Ala Ala Arg Pro Ser Ser Cys Arg Arg 
1               5                   10                  15      


Lys Gln Glu Asp Asp Arg Asp Gly Leu Leu Ala Glu Arg Glu Gln Glu 
            20                  25                  30          


Glu Ala Ile Ala Gln Phe Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser 
        35                  40                  45              


Ile Thr Cys Leu Thr Cys Gln Gly Thr Gly Tyr Ile Pro Thr Glu Gln 
    50                  55                  60                  


Val Asn Glu Leu Val Ala Leu Ile Pro His Ser Asp Gln Arg Leu Arg 
65                  70                  75                  80  


Pro Gln Arg Thr Lys Gln Tyr Val Leu Leu Ser Ile Leu Leu Cys Leu 
                85                  90                  95      


Leu Ala Ser Gly Leu Val Val Phe Phe Leu Phe Pro His Ser Val Leu 
            100                 105                 110         


Val Asp Asp Asp Gly Ile Lys Val Val Lys Val Thr Phe Asn Lys Gln 
        115                 120                 125             


Asp Ser Leu Val Ile Leu Thr Ile Met Ala Thr Leu Lys Ile Arg Asn 
    130                 135                 140                 


Ser Asn Phe Tyr Thr Val Ala Val Thr Ser Leu Ser Ser Gln Ile Gln 
145                 150                 155                 160 


Tyr Met Asn Thr Val Val Ser Thr Tyr Val Thr Thr Asn Val Ser Leu 
                165                 170                 175     


Ile Pro Pro Arg Ser Glu Gln Leu Val Asn Phe Thr Gly Lys Ala Glu 
            180                 185                 190         


Met Gly Gly Pro Phe Ser Tyr Val Tyr Phe Phe Cys Thr Val Pro Glu 
        195                 200                 205             


Ile Leu Val His Asn Ile Val Ile Phe Met Arg Thr Ser Val Lys Ile 
    210                 215                 220                 


Ser Tyr Ile Gly Leu Met Thr Gln Ser Ser Leu Glu Thr His His Tyr 
225                 230                 235                 240 


Val Asp Cys Gly Gly Asn Ser Thr Ala Ile 
                245                 250 


<210>  2978
<211>  3300
<212>  DNA
<213>  Homosapiens

<400>  2978
ctgctgctgc tgcagccacc agagcagaga gccttgagta cactttgcca cagaaagcag     60

tgagcaagaa tgatagctgt ctcttttaaa tgccgttgtc aaattctgag gcgacttact    120

aaagatgaga gtccctacac taaatccgcc agccagacaa agccgcctga tggagcgttg    180

gctgtgagga gacagagcat cccagaggaa ttcaagggct ccacagtcgt cgagctgatg    240

aagaaggaag gcactaccct gggtctgacg gtatcgggag gaattgataa ggatggcaag    300

ccaagagtat ctaatctgcg gcaaggagga attgctgcta gaagtgacca gctggatgtg    360

ggtgactaca tcaaagcagt gaatggaatc aacctggcca aattccgcca tgacgagatc    420

atcagcttgc tgaagaatgt gggagaaaga gtggttcttg aagtagagta cgagcttcca    480

ccggtctctg tgcaaggatc aagtgttatt ttccgaacag tggaggtcac attacataaa    540

gaaggcaata cctttggttt tgtaattcga gggggagcac atgatgatag aaataaatct    600

cgtccagttg tgataacatg tgttcgtcct ggagggcctg ctgacagaga gggcacgatc    660

aaacccggtg acaggttgct cagtgtggat ggaattcggc ttcttggaac tacgcatgct    720

gaagccatga gtattcttaa acaatgtgga caagaagcag cactgctgat agaatatgat    780

gtctcagtaa tggactctgt ggcaacagca tccgggccac tactagtcga agttgccaaa    840

actcctggtg ccagccttgg ggttgcccta actacctcga tgtgctgtaa caaacaagtc    900

attgtcatag acaaaatcaa atctgcaagt attgcagaca gatgtggcgc attgcatgtg    960

ggagatcaca tcctctccat cgatggaacc agcatggagt actgtacact tgcagaagca   1020

acccagttcc tggccaacac cactgaccag gtcaagcttg agatccttcc ccatcatcag   1080

acccggctgg ccctaaaggg gcccgaccat gcagctttgg tgtcttcatc cttctctcct   1140

acctccatga gtgcatacag cctgagttcc ctgaacatgg ggactctacc tcgaagcctc   1200

tactccacca gcccacgtgg aaccatgatg aggaggagac tgaaaaagaa agacttcaaa   1260

agctcattgt ccttagcctc cagcacagta ggattggctg ggcaggttgt tcacacagaa   1320

accacagagg ttgtgctgac ggcagatcct gtcacaggat ttgggatcca actgcagggc   1380

agtgtgtttg ccacagaaac tctctcttct ccacctctga tttcctatat cgaagctgac   1440

agcccagcag agagatgtgg ggtgctacag attggagaca gagtgatggc catcaatgga   1500

attccaacag aagacagcac cttcgaagaa gccagtcagc tcctccgaga ctcttcaatc   1560

acgagcaagg tcacactgga aatcgagttt gatgttgcag agtctgtcat cccaagtagt   1620

ggaacatttc atgtaaagct gcctaagaag cacaatgtgg aacttggaat aaccataagt   1680

tcaccatcca gtagaaaacc aggagacccc ctcgtcattt cagatatcaa gaaagggagt   1740

gtggcacaca gaactgggac cctggaactt ggggataaat tgctcgcaat agataatatc   1800

cggctggaca actgttccat ggaagatgca gttcagatcc tccagcaatg tgaagacctg   1860

gtgaagctca aaatccgcaa agatgaagat aattcagatg agcaagaaag ttccggagca   1920

attatttaca ccgtggagct taaacgctac ggggggcccc ttggcatcac aatttcagga   1980

actgaagagc cgtttgatcc tataatcatt tcaagcctca ctaaaggggg attagctgaa   2040

agaactggcg caatccacat aggagaccga atcctagcca tcaatagcag cagcttgaaa   2100

gggaagcctc tgagtgaagc catccatttg ttacagatgg caggagagac tgtcaccttg   2160

aaaattaaga aacagacaga tgcccagtca gcatcgagcc ccaagaagtt ccctatttct   2220

agccatttga gtgacctggg ggatgtggag gaggactcct caccagcaca gaagccaggc   2280

aagctctccg acatgtaccc ctccacggtg cccagtgtgg acagtgctgt ggattcatgg   2340

gatgggtctg caatagacac cagctatgga actgaaggca ctagttttca ggcctcagga   2400

tacaatttca acacctatga ctggaggagt ccaaaacaga gaggcagctt gtccccagtc   2460

actaagcctc gaagccagac ttacccagat gtggggctga gttatgaaga ctgggaccgg   2520

tccacagcca gtggttttgc aggggctgcc gatagtgcag agacagaaca agaggagaac   2580

ttctggtctc aagcgctgga ggatttggaa acctgcggac agtcaggaat tctgagagaa   2640

ctggaggaga aagctgacag gcgtgtgtct ttgagaaaca tgactctctt ggcaacaatc   2700

atgtcgggga gcacgatgag tttgaatcat gaggctccaa cacctcgcag tcagctgggg   2760

cgacaggcca gcttccagga gcgcagcagc tcgcggccgc actacagcca aacaactcgg   2820

agcaacaccc tgccttcaga tgtgggtagg aagtcagtaa ccctgagaaa aatgaaacaa   2880

gaaataaagg agatcatgtc tccaactcct gtggagctgc acaaggtgac cttgtacaag   2940

gactctgaca tggaggactt tgggttcagt gtagcagatg gcttactgga gaaaggagtg   3000

tatgtcaaaa atattcgccc agctgggcca ggagatcttg gtggcttaaa gccctatgac   3060

aggctcttac aggtgaatca tgtccgaacc agagactttg actgctgcct tgttgtgccc   3120

ctcatagcag aatccgggaa taagctggac ctggttatta gtagaaaccc actggcttca   3180

cagaagtcta tagaccaaca gagtctacca ggagattgga gtgaacagaa cagtgctttt   3240

ttccagcagc ctagccacgg tggtaatttg gagacacgag aacccactaa tacattatag   3300


<210>  2979
<211>  1076
<212>  PRT
<213>  Homosapiens

<400>  2979

Met Ile Ala Val Ser Phe Lys Cys Arg Cys Gln Ile Leu Arg Arg Leu 
1               5                   10                  15      


Thr Lys Asp Glu Ser Pro Tyr Thr Lys Ser Ala Ser Gln Thr Lys Pro 
            20                  25                  30          


Pro Asp Gly Ala Leu Ala Val Arg Arg Gln Ser Ile Pro Glu Glu Phe 
        35                  40                  45              


Lys Gly Ser Thr Val Val Glu Leu Met Lys Lys Glu Gly Thr Thr Leu 
    50                  55                  60                  


Gly Leu Thr Val Ser Gly Gly Ile Asp Lys Asp Gly Lys Pro Arg Val 
65                  70                  75                  80  


Ser Asn Leu Arg Gln Gly Gly Ile Ala Ala Arg Ser Asp Gln Leu Asp 
                85                  90                  95      


Val Gly Asp Tyr Ile Lys Ala Val Asn Gly Ile Asn Leu Ala Lys Phe 
            100                 105                 110         


Arg His Asp Glu Ile Ile Ser Leu Leu Lys Asn Val Gly Glu Arg Val 
        115                 120                 125             


Val Leu Glu Val Glu Tyr Glu Leu Pro Pro Val Ser Val Gln Gly Ser 
    130                 135                 140                 


Ser Val Ile Phe Arg Thr Val Glu Val Thr Leu His Lys Glu Gly Asn 
145                 150                 155                 160 


Thr Phe Gly Phe Val Ile Arg Gly Gly Ala His Asp Asp Arg Asn Lys 
                165                 170                 175     


Ser Arg Pro Val Val Ile Thr Cys Val Arg Pro Gly Gly Pro Ala Asp 
            180                 185                 190         


Arg Glu Gly Thr Ile Lys Pro Gly Asp Arg Leu Leu Ser Val Asp Gly 
        195                 200                 205             


Ile Arg Leu Leu Gly Thr Thr His Ala Glu Ala Met Ser Ile Leu Lys 
    210                 215                 220                 


Gln Cys Gly Gln Glu Ala Ala Leu Leu Ile Glu Tyr Asp Val Ser Val 
225                 230                 235                 240 


Met Asp Ser Val Ala Thr Ala Ser Gly Pro Leu Leu Val Glu Val Ala 
                245                 250                 255     


Lys Thr Pro Gly Ala Ser Leu Gly Val Ala Leu Thr Thr Ser Met Cys 
            260                 265                 270         


Cys Asn Lys Gln Val Ile Val Ile Asp Lys Ile Lys Ser Ala Ser Ile 
        275                 280                 285             


Ala Asp Arg Cys Gly Ala Leu His Val Gly Asp His Ile Leu Ser Ile 
    290                 295                 300                 


Asp Gly Thr Ser Met Glu Tyr Cys Thr Leu Ala Glu Ala Thr Gln Phe 
305                 310                 315                 320 


Leu Ala Asn Thr Thr Asp Gln Val Lys Leu Glu Ile Leu Pro His His 
                325                 330                 335     


Gln Thr Arg Leu Ala Leu Lys Gly Pro Asp His Ala Ala Leu Val Ser 
            340                 345                 350         


Ser Ser Phe Ser Pro Thr Ser Met Ser Ala Tyr Ser Leu Ser Ser Leu 
        355                 360                 365             


Asn Met Gly Thr Leu Pro Arg Ser Leu Tyr Ser Thr Ser Pro Arg Gly 
    370                 375                 380                 


Thr Met Met Arg Arg Arg Leu Lys Lys Lys Asp Phe Lys Ser Ser Leu 
385                 390                 395                 400 


Ser Leu Ala Ser Ser Thr Val Gly Leu Ala Gly Gln Val Val His Thr 
                405                 410                 415     


Glu Thr Thr Glu Val Val Leu Thr Ala Asp Pro Val Thr Gly Phe Gly 
            420                 425                 430         


Ile Gln Leu Gln Gly Ser Val Phe Ala Thr Glu Thr Leu Ser Ser Pro 
        435                 440                 445             


Pro Leu Ile Ser Tyr Ile Glu Ala Asp Ser Pro Ala Glu Arg Cys Gly 
    450                 455                 460                 


Val Leu Gln Ile Gly Asp Arg Val Met Ala Ile Asn Gly Ile Pro Thr 
465                 470                 475                 480 


Glu Asp Ser Thr Phe Glu Glu Ala Ser Gln Leu Leu Arg Asp Ser Ser 
                485                 490                 495     


Ile Thr Ser Lys Val Thr Leu Glu Ile Glu Phe Asp Val Ala Glu Ser 
            500                 505                 510         


Val Ile Pro Ser Ser Gly Thr Phe His Val Lys Leu Pro Lys Lys His 
        515                 520                 525             


Asn Val Glu Leu Gly Ile Thr Ile Ser Ser Pro Ser Ser Arg Lys Pro 
    530                 535                 540                 


Gly Asp Pro Leu Val Ile Ser Asp Ile Lys Lys Gly Ser Val Ala His 
545                 550                 555                 560 


Arg Thr Gly Thr Leu Glu Leu Gly Asp Lys Leu Leu Ala Ile Asp Asn 
                565                 570                 575     


Ile Arg Leu Asp Asn Cys Ser Met Glu Asp Ala Val Gln Ile Leu Gln 
            580                 585                 590         


Gln Cys Glu Asp Leu Val Lys Leu Lys Ile Arg Lys Asp Glu Asp Asn 
        595                 600                 605             


Ser Asp Glu Gln Glu Ser Ser Gly Ala Ile Ile Tyr Thr Val Glu Leu 
    610                 615                 620                 


Lys Arg Tyr Gly Gly Pro Leu Gly Ile Thr Ile Ser Gly Thr Glu Glu 
625                 630                 635                 640 


Pro Phe Asp Pro Ile Ile Ile Ser Ser Leu Thr Lys Gly Gly Leu Ala 
                645                 650                 655     


Glu Arg Thr Gly Ala Ile His Ile Gly Asp Arg Ile Leu Ala Ile Asn 
            660                 665                 670         


Ser Ser Ser Leu Lys Gly Lys Pro Leu Ser Glu Ala Ile His Leu Leu 
        675                 680                 685             


Gln Met Ala Gly Glu Thr Val Thr Leu Lys Ile Lys Lys Gln Thr Asp 
    690                 695                 700                 


Ala Gln Ser Ala Ser Ser Pro Lys Lys Phe Pro Ile Ser Ser His Leu 
705                 710                 715                 720 


Ser Asp Leu Gly Asp Val Glu Glu Asp Ser Ser Pro Ala Gln Lys Pro 
                725                 730                 735     


Gly Lys Leu Ser Asp Met Tyr Pro Ser Thr Val Pro Ser Val Asp Ser 
            740                 745                 750         


Ala Val Asp Ser Trp Asp Gly Ser Ala Ile Asp Thr Ser Tyr Gly Thr 
        755                 760                 765             


Glu Gly Thr Ser Phe Gln Ala Ser Gly Tyr Asn Phe Asn Thr Tyr Asp 
    770                 775                 780                 


Trp Arg Ser Pro Lys Gln Arg Gly Ser Leu Ser Pro Val Thr Lys Pro 
785                 790                 795                 800 


Arg Ser Gln Thr Tyr Pro Asp Val Gly Leu Ser Tyr Glu Asp Trp Asp 
                805                 810                 815     


Arg Ser Thr Ala Ser Gly Phe Ala Gly Ala Ala Asp Ser Ala Glu Thr 
            820                 825                 830         


Glu Gln Glu Glu Asn Phe Trp Ser Gln Ala Leu Glu Asp Leu Glu Thr 
        835                 840                 845             


Cys Gly Gln Ser Gly Ile Leu Arg Glu Leu Glu Glu Lys Ala Asp Arg 
    850                 855                 860                 


Arg Val Ser Leu Arg Asn Met Thr Leu Leu Ala Thr Ile Met Ser Gly 
865                 870                 875                 880 


Ser Thr Met Ser Leu Asn His Glu Ala Pro Thr Pro Arg Ser Gln Leu 
                885                 890                 895     


Gly Arg Gln Ala Ser Phe Gln Glu Arg Ser Ser Ser Arg Pro His Tyr 
            900                 905                 910         


Ser Gln Thr Thr Arg Ser Asn Thr Leu Pro Ser Asp Val Gly Arg Lys 
        915                 920                 925             


Ser Val Thr Leu Arg Lys Met Lys Gln Glu Ile Lys Glu Ile Met Ser 
    930                 935                 940                 


Pro Thr Pro Val Glu Leu His Lys Val Thr Leu Tyr Lys Asp Ser Asp 
945                 950                 955                 960 


Met Glu Asp Phe Gly Phe Ser Val Ala Asp Gly Leu Leu Glu Lys Gly 
                965                 970                 975     


Val Tyr Val Lys Asn Ile Arg Pro Ala Gly Pro Gly Asp Leu Gly Gly 
            980                 985                 990         


Leu Lys Pro Tyr Asp Arg Leu Leu  Gln Val Asn His Val  Arg Thr Arg 
        995                 1000                 1005             


Asp Phe  Asp Cys Cys Leu Val  Val Pro Leu Ile Ala  Glu Ser Gly 
    1010                 1015                 1020             


Asn Lys  Leu Asp Leu Val Ile  Ser Arg Asn Pro Leu  Ala Ser Gln 
    1025                 1030                 1035             


Lys Ser  Ile Asp Gln Gln Ser  Leu Pro Gly Asp Trp  Ser Glu Gln 
    1040                 1045                 1050             


Asn Ser  Ala Phe Phe Gln Gln  Pro Ser His Gly Gly  Asn Leu Glu 
    1055                 1060                 1065             


Thr Arg  Glu Pro Thr Asn Thr  Leu 
    1070                 1075     


<210>  2980
<211>  5913
<212>  DNA
<213>  Homosapiens

<400>  2980
gtggacgcag cgggctttgg aaaggcccca agttaatgag gcgtgcgccg gctgccgagc     60

gcctcttgga gctgggcttt cccccgcggt gcgggcgcca ggagccgcct tttccgctgg    120

gtgtcactcg ggggtgggga agatggccca ttcaaaagcg ccgcgagggg gcccggccag    180

tgcccttcag tgagcgctcg caagaggacg gcagaggccc ggcagctcgg agctccggga    240

ccttgtggcg catcaggacg cggctgtccc tctgccggga cccagagccg ccgccgccgc    300

tctgcctcct gcgtgttagc ctcctctgcg cgctccgggc aggcggccgt gggagccgct    360

ggggcgagga cggcgcgagg ctgctgctgc tgcccccggc ccgcgcggct ggaaacggag    420

aggccgagcc aagcggcggc ccctcttatg ctgggaggat gctggagagt agcggctgca    480

aagcgctgaa ggagggcgtg ctggagaagc gcagcgacgg gttgttgcag ctctggaaga    540

aaaagtgttg catcctcacc gaggaagggc tgctgcttat cccgcccaag cagctgcaac    600

accagcagca gcagcagcaa cagcagcagc agcagcagca acaacagccc gggcaggggc    660

cggccgagcc gtcccaaccc agtggccccg ctgtcgccag cctcgagccg ccggtcaagc    720

tcaaggaact gcacttctcc aacatgaaga ccgtggactg tgtggagcgc aagggcaagt    780

acatgtactt cactgtggtg atggcagagg gcaaggagat cgactttcgg tgcccgcaag    840

accagggctg gaacgccgag atcacgctgc agatggtgca gtacaagaat cgtcaggcca    900

tcctggcggt caaatccacg cggcagaagc agcagcacct ggtccagcag cagcccccct    960

cgcagccgca gccgcagccg cagctccagc cccaacccca gcctcagcct cagccgcaac   1020

cccagcccca atcacaaccc cagcctcagc cccaacccaa gcctcagccc cagcagctcc   1080

acccgtatcc gcatccacat ccacatccac actctcatcc tcactcgcac ccacaccctc   1140

acccgcaccc gcatccgcac caaataccgc acccacaccc acagccgcac tcgcagccgc   1200

acgggcaccg gcttctccgc agcacctcca actctgcctg aaaggggcag ctcccgggca   1260

agacaaggtt ttgaggactt gaggaagtgg gacgagcaca tttctattgt cttcacttgg   1320

atcaaaagca aaacagtctc tccgccccgc accagatcaa gtagtttgga catcacccta   1380

ctgaaaactt gcgattcttc ttagttttct gcatactttt catcacgatg caggaaacga   1440

tttcgagtca agaagacttt tatttatgaa cctttgaaag gatcgtcttg tatggtgaat   1500

tttctaggag cgatgatgta ctgtaatttt attttaatgt attttgattt atgattattt   1560

attagttttt ttttaaatgc ttgttctaag acatttctga atgtagacca ttttccaaaa   1620

aggaaacttt attttcaaaa acctaatccg tagtaattcc taatcttgga gaataaaaaa   1680

gggcggtgga ggggaaaaca ttaagaattt attcattatt tctcgagtac tttcagaaag   1740

tctgacactt tcattgttgt gccagctggt tgaaattaaa actctgatat tacttttttt   1800

gaggattttt atttttgttt ttgcttaaac atatagtttg tctagaagtt taaaaagcta   1860

aaagttaaaa atggtgtaat tatgaaaatc taacactcaa gatagtttct aaaaggaaat   1920

cagtagttaa ggatacctga tttcaaaata tttaaagcat aacctaactg atggtaggat   1980

gattgtatct tgaatatgtg gtagggccac atctattgta ggaaaacctt gcttttatca   2040

tctgtgtgta aagggcttaa taaggagaag aggccttttg actgatttgt gagtataaat   2100

gcatttgctg tttcatttca aaaatgttgt ggaggaaaag agtacattta acttgtataa   2160

gagaatattt gtactcctgt ccaggctgca ggacctttct tcgagagctt tgcacacttg   2220

acttgaacca cattttctga tccctttact ttgttttaga agcacactga aaaatctcgt   2280

tgtttaaagt acaatttgta aatatttcaa aggtctagga gtcataactt ttgttttcat   2340

actgaaaatg atgttgatca gagaaaccaa ctgttttgct tttcattgct ctgtgagaaa   2400

tttgaggatt ctgttttgct gttaggtaag ctaaactcag aaattgaaaa ggaaaagact   2460

ggataaacac aggattttca gtaagaaaac aaccccagtc ttgtcttaga agccacttgt   2520

tgaggagtct gttgggggaa aaaagaggat atgcttttaa aggtagaaca aaccttcttc   2580

tgtgttaaat caaaaggatg ttcaaaatcc accaggacag atgctacttg ggtttaaatg   2640

gagccataga tgatacaaag tcctcttggg gctgaaaatc acttcctatt tgcatggctt   2700

tactaactgg tttctgtttt ccattatctt tttcacagaa agtcttggtc agtatttttc   2760

cagcatttaa attgaaacgg tcagtattag accactgcta ggttatgtag tcaagaaata   2820

aaaatagaat tacatgctac agatgtcttt attctccttc catctagaaa ggagttccaa   2880

ggtcaaatta ctttttagtg caatagttaa atgacatttt gagatcataa ctcatatcca   2940

aaaagttgca gggaaaatta aaatagcttt cccctattaa gctaatggca aacaaaactt   3000

aagtggaccc ccacttccag tggttgttta ggttgcagtt gtgaaaatat gctgccaaca   3060

tttaaaaact tgtttcatat gtatatatgt atacacatat atgaatatgt atgtatatat   3120

acatatatga gaacatgtgt gtacacatat atgaatatgt atatatgtgt atgtatgtat   3180

atatgtatat gaaatgagag ccacatctaa agatttctta aatcaagttt ggttcagctt   3240

ccttagaact gtggctgtac tttttgagga gtacctcata gtactatatt tttaatgcat   3300

gcaaatcata atagctccaa atgaaccaca gttttttccc aatggaggat ttttttttaa   3360

ttcttgtact aaaaaaaaaa aatccatacc aaatattttt acaaattaag attgatgtag   3420

gttttaaaaa aggcatttgt atgttgttag cttacatatg gggctaggta atttcattgc   3480

ttaaaaagat gcgcctaggc tccctcttgg tggctggatt tctttttctt cgcccgtggt   3540

ggccatggtt cttaataggg ccaccggaat catggtttct tttttttttt ttttttttga   3600

gatggagtct cgccctgtga cccaggctgg agtgcagtgg cacgatctcg gctcactgca   3660

acctctgcct cctgggttca cgccattctc ctgtctcagc ctcctgagta gctgggacta   3720

caggtgaatg ccaccacgcc cggctgattt ttgtattttt agtagagatg gggtttcacc   3780

atagtggtca ggctgttctc gaactcctga cctcaggtga tccacctgcc ttggcctccc   3840

aaagtgctag gattacaggt gtgagccacc acacccggcc ccagaataat ggtttcttga   3900

ctttctgtag cccttgttcc ttagtctgct gtgatattta tgttgacctt tatcattttc   3960

tattctgaac ccctcttagc atttaatgtg aaatctaaga aattagaagt agaatggctt   4020

ttattgtttt gacacctttg aaattattat taataatttt tccagagcaa aaaagcaaac   4080

acgctcaata agactaaaca aaacaaaata taaatgtaca tcatttaatg tcccagtggc   4140

tctattctac ctgtaagaaa atgatacaaa accacctaag atattttgaa gcctgacaaa   4200

tcagcttcat ggaaaaaggt aaaaaatgca tttttcaacc gaaagggcag atccaataga   4260

agacccgctc cttaaataaa cataaaatgt aaaaagttgg aaaattaaga gtaatgttcc   4320

atctggaaac tgaacttttg tccttgaact tgtgttggca ccaagcctca tacacagtga   4380

gctcaataac tgttgggaca aaggaaggaa ggacaaaatg tgtaacttcc cagcatctgg   4440

gagatgctgt ctcttgcctc actgagtgtt ccttttcttt gctctcatgt cattccctga   4500

gaacaatgaa ttctgggaca ggctaaacat catgatgaag tttcttaaac agactttctt   4560

agtggaaatc catttagatc tgggtgtgct ctatggggag tgctgacgtc aaagagcaaa   4620

tgtctataag gggccctttt aaaatgaaca ttttcctcat tgagcaagct gggattctct   4680

aatgtagaaa tcaagccatc tttataattt cacttcagat gtttatgttt ttgttttttt   4740

tgtctccaat gatggtaaaa ataaaaacta cgcattactt aaaggagttt ccctcacatg   4800

taaacactgt taggaagtct ggattaagtt gaaagtcctg ttttaacttt ttttctctca   4860

tataccaaac actctgtatt tctcttaaag aagcccttta agagaaagcc ctaattttat   4920

atctgacagt aaagtttgct gcaagtgtat gagttcaaac acatcccttg ttttctgtcc   4980

ctaggggaaa agtcatgtag ttttagcttg gctccagtgt taatattata ttcagtagca   5040

gccttagaag agtggtctaa gacttgaacc tggagcaatt ttatagcaca gaatcctacg   5100

aagataggac tgtgaacatt tgttttcttt ttcgtgtgtg tcaaactaac tggtttttgc   5160

tttaccaata aaatgtcctc ggcagagtaa attttaaacg tgaaaattat agatcttgat   5220

attgaatcca tcagtgattc aagagataca cctatttgcc taaaacaacc taagatgtat   5280

tggttatgga atcatgtgtt ggataggttc ttaagacctg tttcctcaaa tcttgacaca   5340

gttttcaagg gtggcttatt gacttgcacg gttgggcaga taatccagat ttacctaaga   5400

ttgggtaaaa aagtcatctg tgactttgct ggcagggcat ttgctaagtg gagtacagga   5460

tctaaaaggg ttttcttaga aagggcaata ttgtccaatg aagtaagcag aaggactctg   5520

ggttagaagc atctgcacaa aaactggtga gacctactct ccactgctct gcagctggat   5580

ggctgatggc aggctgagca gtggggaagc aggttttaac aacagggagt ccttccaggt   5640

cactgtatat tgagaagaaa cataaaacta ttgtctgtta cattccgagg tcagccttct   5700

tcttaacgtt ttataatatg caaatgccag cttctggaaa gcaagtatca tcatgtacca   5760

aatgctttat acaccatcac attcatgaat tttttagcat ggtcagaact tgtgtaaata   5820

tgtctcttag atgattttgg ggagatgtga tttatttttc atattttcaa aatgcatttc   5880

atttcaaata aagttatcta ttgagacaac cga                                5913


<210>  2981
<211>  401
<212>  PRT
<213>  Homosapiens

<400>  2981

Met Arg Arg Ala Pro Ala Ala Glu Arg Leu Leu Glu Leu Gly Phe Pro 
1               5                   10                  15      


Pro Arg Cys Gly Arg Gln Glu Pro Pro Phe Pro Leu Gly Val Thr Arg 
            20                  25                  30          


Gly Trp Gly Arg Trp Pro Ile Gln Lys Arg Arg Glu Gly Ala Arg Pro 
        35                  40                  45              


Val Pro Phe Ser Glu Arg Ser Gln Glu Asp Gly Arg Gly Pro Ala Ala 
    50                  55                  60                  


Arg Ser Ser Gly Thr Leu Trp Arg Ile Arg Thr Arg Leu Ser Leu Cys 
65                  70                  75                  80  


Arg Asp Pro Glu Pro Pro Pro Pro Leu Cys Leu Leu Arg Val Ser Leu 
                85                  90                  95      


Leu Cys Ala Leu Arg Ala Gly Gly Arg Gly Ser Arg Trp Gly Glu Asp 
            100                 105                 110         


Gly Ala Arg Leu Leu Leu Leu Pro Pro Ala Arg Ala Ala Gly Asn Gly 
        115                 120                 125             


Glu Ala Glu Pro Ser Gly Gly Pro Ser Tyr Ala Gly Arg Met Leu Glu 
    130                 135                 140                 


Ser Ser Gly Cys Lys Ala Leu Lys Glu Gly Val Leu Glu Lys Arg Ser 
145                 150                 155                 160 


Asp Gly Leu Leu Gln Leu Trp Lys Lys Lys Cys Cys Ile Leu Thr Glu 
                165                 170                 175     


Glu Gly Leu Leu Leu Ile Pro Pro Lys Gln Leu Gln His Gln Gln Gln 
            180                 185                 190         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gly Gln Gly 
        195                 200                 205             


Pro Ala Glu Pro Ser Gln Pro Ser Gly Pro Ala Val Ala Ser Leu Glu 
    210                 215                 220                 


Pro Pro Val Lys Leu Lys Glu Leu His Phe Ser Asn Met Lys Thr Val 
225                 230                 235                 240 


Asp Cys Val Glu Arg Lys Gly Lys Tyr Met Tyr Phe Thr Val Val Met 
                245                 250                 255     


Ala Glu Gly Lys Glu Ile Asp Phe Arg Cys Pro Gln Asp Gln Gly Trp 
            260                 265                 270         


Asn Ala Glu Ile Thr Leu Gln Met Val Gln Tyr Lys Asn Arg Gln Ala 
        275                 280                 285             


Ile Leu Ala Val Lys Ser Thr Arg Gln Lys Gln Gln His Leu Val Gln 
    290                 295                 300                 


Gln Gln Pro Pro Ser Gln Pro Gln Pro Gln Pro Gln Leu Gln Pro Gln 
305                 310                 315                 320 


Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Ser Gln Pro Gln 
                325                 330                 335     


Pro Gln Pro Gln Pro Lys Pro Gln Pro Gln Gln Leu His Pro Tyr Pro 
            340                 345                 350         


His Pro His Pro His Pro His Ser His Pro His Ser His Pro His Pro 
        355                 360                 365             


His Pro His Pro His Pro His Gln Ile Pro His Pro His Pro Gln Pro 
    370                 375                 380                 


His Ser Gln Pro His Gly His Arg Leu Leu Arg Ser Thr Ser Asn Ser 
385                 390                 395                 400 


Ala 
    


<210>  2982
<211>  2908
<212>  DNA
<213>  Homosapiens

<400>  2982
ctgctcgcgg cgccgcctcc tgctcctccc gctgctgctg ccgctgccgc cctgagtcac     60

tgcctgcgca gctccggccg cctggctccc catactagtc gccgatattt ggagttctta    120

caacatggca gacattgaca acaaagaaca gtctgaactt gatcaagatt tggatgatgt    180

tgaagaagta gaagaagagg aaactggtga agaaacaaaa ctcaaagcac gtcagctaac    240

tgttcagatg atgcaaaatc ctcagattct tgcagccctt caagaaagac ttgatggtct    300

ggtagaaaca ccaacaggat acattgaaag cctgcctagg gtagttaaaa gacgagtgaa    360

tgctctcaaa aacctgcaag ttaaatgtgc acagatagaa gccaaattct atgaggaagt    420

tcacgatctt gaaaggaagt atgctgttct ctatcagcct ctatttgata agcgatttga    480

aattattaat gcaatttatg aacctacgga agaagaatgt gaatggaaac cagatgaaga    540

agatgagatt tcggaggaat tgaaagaaaa ggccaagatt gaagatgaga aaaaggatga    600

agaaaaagaa gaccccaaag gaattcctga attttggtta actgttttta agaatgttga    660

cttgctcagt gatatggttc aggaacacga tgaacctatt ctgaagcact tgaaagatat    720

taaagtgaag ttctcagatg ctggccagcc tatgagtttt gtcttagaat ttcactttga    780

acccaatgaa tattttacaa atgaagtgct gacaaagaca tacaggatga ggtcagaacc    840

agatgattct gatccctttt cttttgatgg accagaaatt atgggttgta cagggtgcca    900

gatagattgg aaaaaaggaa agaatgtcac tttgaaaact attaagaaga agcagaaaca    960

caagggacgt gggacagttc gtactgtgac taaaacagtt tccaatgact ctttctttaa   1020

cttttttgcc cctcctgaag ttcctgagag tggagatctg gatgatgatg ctgaagctat   1080

ccttgctgca gacttcgaaa ttggtcactt tttacgtgag cgtataatcc caagatcagt   1140

gttatatttt actggagaag ctattgaaga tgatgatgat gattatgatg aagaaggtga   1200

agaagcggat gaggaagggg aagaagaagg agatgaggaa aatgatccag actatgaccc   1260

aaagaaggat caaaacccag cagagtgcaa gcagcagtga agcaggatgt atgtggcctt   1320

gaggataacc tgcactggtc taccttctgc ttccctggaa aggatgaatt tacatcattt   1380

gacaagccta ttttcaagtt atttgttgtt tgtttgcttg tttttgtttt tgcagctaaa   1440

ataaaaattt caaatacaat tttagttctt acaagataat gtcttaattt tgtaccaatt   1500

caggtagaag tagaggccta ccttgaatta agggttatac tcagttttta acacattgtt   1560

gaagaaaagg taccagcttt ggaacgagat gctatactaa taagcaagtg taaaaaaaaa   1620

aaaaaaagag gaagaaaatc ttaagtgatt gatgctgttt tcttttaaaa aaaaaaaaaa   1680

aaattcattt tctttgggtt agagctagag agaaggcccc aagcttctat ggtttcttct   1740

aattcttatt gcttaaagta tgagtatgtc acttacccgt gcttctgttt actgtgtaat   1800

taaaatgggt agtactgttt acctaactac ctcatggatg tgttaaggca tattgagtta   1860

aatctcatat aatgtttctc aatcttgtta aaagctcaaa attttgggcc tatttgtaat   1920

gccagtgtga cactaagcat tttgttcaca ccacgctttg ataactaaac tggaaaacaa   1980

aggtgttaag tacctctgtt ctggatctgg gcagtcagca ctctttttag atctttgtgt   2040

ggctcctatt tttatagaag tggagggatg cactatttca caaggtccaa gatttgtttt   2100

cagatatttt tgatgactgt attgtaaata ctacagggat agcactatag tattgtagtc   2160

atgagactta aagtggaaat aagactattt ttgacaaaag atgccattaa atttcagact   2220

gtagagccac atttacaata cctcaggcta attactgtta attttggggt tgaacttttt   2280

ttgacagtga gggtggatta ttggattgtc attagaggaa ggtctagatt tcctgctctt   2340

aataaaatta cattgaattg atttttagag gtaatgaaaa cttcctttct gagaagttag   2400

tgttaaggtc ttggaatgtg aacacattgt ttgtagtgct atccattcct ctcctgagat   2460

tttaacttac tactggaaat ccttaaccaa ttataatagc tttttttctt tattttcaaa   2520

atgatttcct ttgctttgat tagacactat gtgctttttt tttttaacca tagttcatcg   2580

aaatgcagct ttttctgaac ttcaaagata gaatcccatt tttaatgaac tgaagtagca   2640

aaatcatctt tttcattctt taggaaatag ctattgccaa agtgaaggtg tagataatac   2700

ctagtcttgt tacataaagg ggatgtggtt tgcagaagaa ttttctttat aaaattgaag   2760

ttttaaggga cgtcagtgtt tatgccattt ttccagttcc aaaatgattc cattccattc   2820

tagaaatttg aagtatgtaa cctgaaatcc ttaataaaat ttggatttaa ttttataaaa   2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                      2908


<210>  2983
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  2983

Met Ala Asp Ile Asp Asn Lys Glu Gln Ser Glu Leu Asp Gln Asp Leu 
1               5                   10                  15      


Asp Asp Val Glu Glu Val Glu Glu Glu Glu Thr Gly Glu Glu Thr Lys 
            20                  25                  30          


Leu Lys Ala Arg Gln Leu Thr Val Gln Met Met Gln Asn Pro Gln Ile 
        35                  40                  45              


Leu Ala Ala Leu Gln Glu Arg Leu Asp Gly Leu Val Glu Thr Pro Thr 
    50                  55                  60                  


Gly Tyr Ile Glu Ser Leu Pro Arg Val Val Lys Arg Arg Val Asn Ala 
65                  70                  75                  80  


Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe Tyr 
                85                  90                  95      


Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln Pro 
            100                 105                 110         


Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro Thr 
        115                 120                 125             


Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Ile Ser Glu 
    130                 135                 140                 


Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu Glu 
145                 150                 155                 160 


Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe Lys 
                165                 170                 175     


Asn Val Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro Ile 
            180                 185                 190         


Leu Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly Gln 
        195                 200                 205             


Pro Met Ser Phe Val Leu Glu Phe His Phe Glu Pro Asn Glu Tyr Phe 
    210                 215                 220                 


Thr Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro Asp 
225                 230                 235                 240 


Asp Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys Thr 
                245                 250                 255     


Gly Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys Thr 
            260                 265                 270         


Ile Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr Val 
        275                 280                 285             


Thr Lys Thr Val Ser Asn Asp Ser Phe Phe Asn Phe Phe Ala Pro Pro 
    290                 295                 300                 


Glu Val Pro Glu Ser Gly Asp Leu Asp Asp Asp Ala Glu Ala Ile Leu 
305                 310                 315                 320 


Ala Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile Pro 
                325                 330                 335     


Arg Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp Asp 
            340                 345                 350         


Asp Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu Glu 
        355                 360                 365             


Gly Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln Asn 
    370                 375                 380                 


Pro Ala Glu Cys Lys Gln Gln 
385                 390     


<210>  2984
<211>  3582
<212>  DNA
<213>  Homosapiens

<400>  2984
ctgctcgcgg cgccgcctcc tgctcctccc gctgctgctg ccgctgccgc cctgagtcac     60

tgcctgcgca gctccggccg cctggctccc catactagtc gccgatattt ggagttctta    120

caacatggca gacattgaca acaaagaaca gtctgaactt gatcaagatt tggatgatgt    180

tgaagaagta gaagaagagg aaactggtga agaaacaaaa ctcaaagcac gtcagctaac    240

tgttcagatg atgcaaaatc ctcagattct tgcagccctt caagaaagac ttgatggtct    300

ggtagaaaca ccaacaggat acattgaaag cctgcctagg gtagttaaaa gacgagtgaa    360

tgctctcaaa aacctgcaag ttaaatgtgc acagatagaa gccaaattct atgaggaagt    420

tcacgatctt gaaaggaagt atgctgttct ctatcagcct ctatttgata agcgatttga    480

aattattaat gcaatttatg aacctacgga agaagaatgt gaatggaaac cagatgaaga    540

agatgagatt tcggaggaat tgaaagaaaa ggccaagatt gaagatgaga aaaaggatga    600

agaaaaagaa gaccccaaag gaattcctga attttggtta actgttttta agaatgttga    660

cttgctcagt gatatggttc aggaacacga tgaacctatt ctgaagcact tgaaagatat    720

taaagtgaag ttctcagatg ctggccagcc tatgagtttt gtcttagaat ttcactttga    780

acccaatgaa tattttacaa atgaagtgct gacaaagaca tacaggatga ggtcagaacc    840

agatgattct gatccctttt cttttgatgg accagaaatt atgggttgta cagggtgcca    900

gatagattgg aaaaaaggaa agaatgtcac tttgaaaact attaagaaga agcagaaaca    960

caagggacgt gggacagttc gtactgtgac taaaacagtt tccaatgact ctttctttaa   1020

cttttttgcc cctcctgaag ttcctgagag tggagatctg gatgatgatg ctgaagctat   1080

ccttgctgca gacttcgaaa ttggtcactt tttacgtgag cgtataatcc caagatcagt   1140

gttatatttt actggagaag ctattgaaga tgatgatgat gattatgatg aagaaggtga   1200

agaagcggat gaggaagggg aagaagaagg agatgaggaa aatgatccag actatgaccc   1260

aaagaaggat caaaacccag cagagtgcaa gcagcagtga agcaggatgt atgtggcctt   1320

gaggataacc tgcactgtaa tagcctaaac acaactctta tttacttaca gccttatgtt   1380

tttgtatttt cttggtagac taggtaattt ttttttaaag gacaggaaac tgatatttta   1440

aagaccaatt tgttctacct agcattttaa ctagtttttc tgccagctat gttgaatgca   1500

caaattctgt cacgcatgtt cattcattgc tacataattt ggttcttctg gaatattttt   1560

atgtagctct tggagtacag ctatgaaaat taacaactgt taaaggaaat accttttttt   1620

tttttttgta attttttcct tgaagaacca aagtattttt tcagctggtt gttgaatagg   1680

gttaagtccg cttggattag ctgtgccttt cattactttg ttacagaaat gcagtgactt   1740

atactaagac aatttattgt ttaaaaaaaa aattggcaag acaactatat ggttaagaat   1800

ttccagtatg accacaccca ataactgtta ttagagtgtt aatggattat tgtgttttag   1860

gtgacatagt taactgtaaa gtaacctgac tcagtatagt tactggtacc acagtgaggt   1920

gaataaaacg ggattttcag aagttagcct gaatttaact gtatttttaa atttaacctc   1980

cattaactaa gcatcttttc tttgtggtag ggtctacctt ctgcttccct ggaaaggatg   2040

aatttacatc atttgacaag cctattttca agttatttgt tgtttgtttg cttgtttttg   2100

tttttgcagc taaaataaaa atttcaaata caattttagt tcttacaaga taatgtctta   2160

attttgtacc aattcaggta gaagtagagg cctaccttga attaagggtt atactcagtt   2220

tttaacacat tgttgaagaa aaggtaccag ctttggaacg agatgctata ctaataagca   2280

agtgtaaaaa aaaaaaaaaa agaggaagaa aatcttaagt gattgatgct gttttctttt   2340

aaaaaaaaaa aaaaaaattc attttctttg ggttagagct agagagaagg ccccaagctt   2400

ctatggtttc ttctaattct tattgcttaa agtatgagta tgtcacttac ccgtgcttct   2460

gtttactgtg taattaaaat gggtagtact gtttacctaa ctacctcatg gatgtgttaa   2520

ggcatattga gttaaatctc atataatgtt tctcaatctt gttaaaagct caaaattttg   2580

ggcctatttg taatgccagt gtgacactaa gcattttgtt cacaccacgc tttgataact   2640

aaactggaaa acaaaggtgt taagtacctc tgttctggat ctgggcagtc agcactcttt   2700

ttagatcttt gtgtggctcc tatttttata gaagtggagg gatgcactat ttcacaaggt   2760

ccaagatttg ttttcagata tttttgatga ctgtattgta aatactacag ggatagcact   2820

atagtattgt agtcatgaga cttaaagtgg aaataagact atttttgaca aaagatgcca   2880

ttaaatttca gactgtagag ccacatttac aatacctcag gctaattact gttaattttg   2940

gggttgaact ttttttgaca gtgagggtgg attattggat tgtcattaga ggaaggtcta   3000

gatttcctgc tcttaataaa attacattga attgattttt agaggtaatg aaaacttcct   3060

ttctgagaag ttagtgttaa ggtcttggaa tgtgaacaca ttgtttgtag tgctatccat   3120

tcctctcctg agattttaac ttactactgg aaatccttaa ccaattataa tagctttttt   3180

tctttatttt caaaatgatt tcctttgctt tgattagaca ctatgtgctt ttttttttta   3240

accatagttc atcgaaatgc agctttttct gaacttcaaa gatagaatcc catttttaat   3300

gaactgaagt agcaaaatca tctttttcat tctttaggaa atagctattg ccaaagtgaa   3360

ggtgtagata atacctagtc ttgttacata aaggggatgt ggtttgcaga agaattttct   3420

ttataaaatt gaagttttaa gggacgtcag tgtttatgcc atttttccag ttccaaaatg   3480

attccattcc attctagaaa tttgaagtat gtaacctgaa atccttaata aaatttggat   3540

ttaattttat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                      3582


<210>  2985
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  2985

Met Ala Asp Ile Asp Asn Lys Glu Gln Ser Glu Leu Asp Gln Asp Leu 
1               5                   10                  15      


Asp Asp Val Glu Glu Val Glu Glu Glu Glu Thr Gly Glu Glu Thr Lys 
            20                  25                  30          


Leu Lys Ala Arg Gln Leu Thr Val Gln Met Met Gln Asn Pro Gln Ile 
        35                  40                  45              


Leu Ala Ala Leu Gln Glu Arg Leu Asp Gly Leu Val Glu Thr Pro Thr 
    50                  55                  60                  


Gly Tyr Ile Glu Ser Leu Pro Arg Val Val Lys Arg Arg Val Asn Ala 
65                  70                  75                  80  


Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe Tyr 
                85                  90                  95      


Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln Pro 
            100                 105                 110         


Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro Thr 
        115                 120                 125             


Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Ile Ser Glu 
    130                 135                 140                 


Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu Glu 
145                 150                 155                 160 


Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe Lys 
                165                 170                 175     


Asn Val Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro Ile 
            180                 185                 190         


Leu Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly Gln 
        195                 200                 205             


Pro Met Ser Phe Val Leu Glu Phe His Phe Glu Pro Asn Glu Tyr Phe 
    210                 215                 220                 


Thr Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro Asp 
225                 230                 235                 240 


Asp Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys Thr 
                245                 250                 255     


Gly Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys Thr 
            260                 265                 270         


Ile Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr Val 
        275                 280                 285             


Thr Lys Thr Val Ser Asn Asp Ser Phe Phe Asn Phe Phe Ala Pro Pro 
    290                 295                 300                 


Glu Val Pro Glu Ser Gly Asp Leu Asp Asp Asp Ala Glu Ala Ile Leu 
305                 310                 315                 320 


Ala Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile Pro 
                325                 330                 335     


Arg Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp Asp 
            340                 345                 350         


Asp Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu Glu 
        355                 360                 365             


Gly Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln Asn 
    370                 375                 380                 


Pro Ala Glu Cys Lys Gln Gln 
385                 390     


<210>  2986
<211>  1071
<212>  DNA
<213>  Homosapiens

<400>  2986
ctgtaattgc acagattgtt cctcttacaa gagaaatatc cagagctcta agaaaacaac     60

tgatgaaaac gacatgcgtg acatttggtg ctgaagaccc aggtcagaga gactcctttg    120

ggggaccagt ccgctgtcct tgccctcact ctgtgaggag acccacctac gacctcgggt    180

cctcagacca accagctcaa ggaacatctc accaatttca aatcgggacc ccactggaaa    240

atggactgtc caactcaccc ggcagccact cccagagccc ctggaactct ggcccaaggc    300

tctctgactg actccttccc agatcttctc ggctcagcag ctgaagactg acactgcttg    360

attgcctggg aagcctatag gaccatcaca gacactttgg ataactctta cagtgaagga    420

caaaaaagcg ccactgcagg gaggaatgcc agggtcccat agagggagac cgacagtgaa    480

gtggagcctg ccatgaattc accaaaggcc attctccctt tcttccagaa gaacagcatt    540

tagctgggcc tatggctacc tacctaaaga ctgcacctct tagtcaccct tgtggccagg    600

tgtggccacg tgacagtgga atgtaagtgg aagtgatgta tgcacttggg ttcattggtt    660

taaaaaaaaa tatgaccgcc ctccatttcc actctttgtc ttatctgtga atgggaacat    720

ggctgtgtct gcagcccgac tttgtgcagc aaaggacaag gccctagggg aaggtggaga    780

aacaagatgg aacaacttgg acccaacaac ttggatccct atgtggccat gtggagtcat    840

ctcacccacc tgggccactc accccgaaga ctgttgtgtg agggtgaaat aaacttctgt    900

atcactagcc cctgcatttc agaaattctt tgttatggca gttttgcctt tatcctaaca    960

cagacagcaa agtatcttct gtggccccat gactaatttc gttgtttaaa ctcattataa   1020

aaactatata aataaaatat taaaaatcaa ataaaatagc aagataacac t            1071


<210>  2987
<211>  82
<212>  PRT
<213>  Homosapiens

<400>  2987

Met Lys Thr Thr Cys Val Thr Phe Gly Ala Glu Asp Pro Gly Gln Arg 
1               5                   10                  15      


Asp Ser Phe Gly Gly Pro Val Arg Cys Pro Cys Pro His Ser Val Arg 
            20                  25                  30          


Arg Pro Thr Tyr Asp Leu Gly Ser Ser Asp Gln Pro Ala Gln Gly Thr 
        35                  40                  45              


Ser His Gln Phe Gln Ile Gly Thr Pro Leu Glu Asn Gly Leu Ser Asn 
    50                  55                  60                  


Ser Pro Gly Ser His Ser Gln Ser Pro Trp Asn Ser Gly Pro Arg Leu 
65                  70                  75                  80  


Ser Asp 
        


<210>  2988
<211>  3583
<212>  DNA
<213>  Homosapiens

<400>  2988
attccgtttc cggccgttcc cacccctgtt ttcggtcggc ccgggtgttc tgcaagctgg     60

tcaaaaaggg gaagcggccc agatatgtta agttctatgg ccgctgcagg gtctgtgaag    120

gcggcgttgc aggtggccga ggtgctggaa gccatcgtga gctgctgcgt ggggcccgag    180

ggacggcaag ttttgtgtac gaagcccact ggcgaggtgc ttctcagccg gaatggaggc    240

cgcctcctgg aggcgctaca cttagagcat cccatagcca ggatgatagt ggactgtgtt    300

tccagtcatc tcaaaaaaac aggagatggt gcaaaaacat ttattatctt tctttgccat    360

ttgcttagag gacttcatgc aatcacagac agagaaaagg atcctttgat gtgtgaaaac    420

attcaaaccc atggaaggca ttggaaaaat tgttctcggt ggaaatttat ttcccaggct    480

ctcctaacgt ttcagacaca aatattagac ggtattatgg accagtacct aagtagacac    540

tttttgtcta tcttttcgtc tgctaaagag agaacattgt gtaggagctc tttagagttg    600

ctcttagaag catacttttg tggaagagtg ggaagaaata atcataaatt tatttcacag    660

ttgatgtgtg actacttttt caagtgtatg acttgtaaaa gtgggattgg tgtatttgag    720

ttagtggatg accattttgt agagttgaat gttggtgtca ctggccttcc tgtttcagat    780

tccaggatca tagctggtct tgtgcttcag aaagattttt ctgtgtaccg cccagcagat    840

ggtgacatgc gaatggtgat agtaacagaa accattcagc ctcttttttc cacttctgga    900

tcagagttta ttctaaattc agaagcacag tttcagacat ctcaattttg gattatggaa    960

aagacaaaag caataatgaa acatctacat agtcagaatg taaaattgct catatctagt   1020

gtgaaacaac cagatttagt tagttattat gcaggggtga atggcatatc agtggttgag   1080

tgtttatcat cagaagaagt ttctcttatc cggaggatca ttggtctttc tccatttgta   1140

ccaccacagg ccttttcgca gtgtgaaata cctaacactg ctttggtgaa attttgtaaa   1200

cctcttatcc ttagatccaa aagatatgtt catctaggct tgataagcac atgtgcattt   1260

ataccacact ctatagttct ttgtggacca gtgcatggtc tcattgaaca acatgaggat   1320

gctttacatg gagcacttaa aatgcttcgg caattattta aagaccttga tctaaattac   1380

atgacacaaa ccaatgacca aaatggcact tcaagtcttt ttatttataa gaacagtgga   1440

gaaagttatc aagcaccaga tcctggtaat ggctcaatac aaaggcctta tcaggacaca   1500

gttgcagaga acaaagatgc attggaaaaa actcaaacat atttaaaagt acattctaat   1560

ttggtaattc cagatgtaga attagaaaca tatattccgt attcaacccc cacactgaca   1620

ccaacagata cattccaaac agttgaaacg ctgacatgtt tgtctttgga aagaaacagg   1680

ctaactgatt attatgaacc attactcaag aacaattcca ctgcttattc aacaagggga   1740

aatagaatag aaatttctta cgaaaattta caggtcacaa atattactag aaagggaagc   1800

atgttaccag tgagctgtaa gttaccgaat atgggtactt cccagagtta cctttcctca   1860

tctatgccag ctggttgtgt tttgccagta ggtggtaatt ttgagatctt gttacattac   1920

tatcttctca attatgccaa aaaatgccat caatcagaag aaaccatggt tagtatgata   1980

atagctaatg cacttttagg cattcccaaa gtcctttata aatctaaaac aggaaagtac   2040

agctttccac atacatatat aagagctgtc catgcactgc aaaccaatca acccttggta   2100

agcagtcaga caggtttgga atcagtaatg ggtaaatacc agctactaac ttcagttctt   2160

cagtgtttga caaaaatatt aaccattgac atggtaatca ctgttaagag acaccctcag   2220

aaagttcaca atcaagattc agaagatgaa ctataacatc agaagttttt aattaaccaa   2280

acttttcatc taactcaagc caagtaaagc agtcatgtga ccactggttc taaagtcagt   2340

tcagtctact taggaaaata gcgtaacttt aaaagtcttt agaagaagca cactaaggtc   2400

accagaccag atacaaatat taaattactt tatggaacaa atctagaggg gaagccaaga   2460

tttggctaag tgtgtctgtt ttttccctat tttatgcctc tgtgtctcag ctctgtgtta   2520

gcctatgtgt ttaggggagg gtttttcttt atagctcctt tttactctcc tgtatctttt   2580

tcactccagc cctccttcat cgttacatgt ttagttcata gaatcattta atctctgatt   2640

tgggtgggct tattctaatt gtttttaata ttgaatacat tatttgcatt aattttccct   2700

actcatactt tgtaaagctg agtaaaaggc tcaaattatt tttttcaaaa agcataaaat   2760

taaattagca gtgagtaaaa ggctcaaatt ttttttcaaa aagcataaaa ttaattttta   2820

cttttatgtg gtcattggtt tactgccact tcatttggaa aacttggata gattttcacc   2880

tttgatatac ctttgaatat atgttacctg aaatataact gtgcattgtt aactctttca   2940

tttctgtagt aaaaggttaa tactagaaag gatatgcaat taatactttg attttctcct   3000

gaccccaaga gcttgtaagg atatgtcatg tatttactgg tttttcttgt atctggtgca   3060

tagccagagt tccacagtaa caaataattt gacaattttt atttctaatg tttatttctg   3120

ttttattttt aatttttatt tctaatttat ttcatttaca aatgttcata ttttaaaaac   3180

ttgtcaatgt aaataatatg atgcatctta tcatggacaa ggacagtgtt ttctaccttt   3240

atcagttctc tgtaataccc aaaacagtgc tgtatttact ccaagtattc agaagtgctt   3300

gttgaacaaa acagtgttat ctttaattca ttcctttaaa tacatgtttc cagtttactt   3360

attcaacaga ttcttacttg ggattgactg aagaaaaaaa actttaatta tagttgaata   3420

agtgttgact aatgtatttt aaaaactata atatcaaaat tttttatatt aaatgtaatt   3480

ctgatttttt aaacatttat gctatatgat gcattatttt gtttctgtga atatggagag   3540

aataaattag ctcttttgct gaattcatgg atgaatgaac ttt                     3583


<210>  2989
<211>  723
<212>  PRT
<213>  Homosapiens

<400>  2989

Met Leu Ser Ser Met Ala Ala Ala Gly Ser Val Lys Ala Ala Leu Gln 
1               5                   10                  15      


Val Ala Glu Val Leu Glu Ala Ile Val Ser Cys Cys Val Gly Pro Glu 
            20                  25                  30          


Gly Arg Gln Val Leu Cys Thr Lys Pro Thr Gly Glu Val Leu Leu Ser 
        35                  40                  45              


Arg Asn Gly Gly Arg Leu Leu Glu Ala Leu His Leu Glu His Pro Ile 
    50                  55                  60                  


Ala Arg Met Ile Val Asp Cys Val Ser Ser His Leu Lys Lys Thr Gly 
65                  70                  75                  80  


Asp Gly Ala Lys Thr Phe Ile Ile Phe Leu Cys His Leu Leu Arg Gly 
                85                  90                  95      


Leu His Ala Ile Thr Asp Arg Glu Lys Asp Pro Leu Met Cys Glu Asn 
            100                 105                 110         


Ile Gln Thr His Gly Arg His Trp Lys Asn Cys Ser Arg Trp Lys Phe 
        115                 120                 125             


Ile Ser Gln Ala Leu Leu Thr Phe Gln Thr Gln Ile Leu Asp Gly Ile 
    130                 135                 140                 


Met Asp Gln Tyr Leu Ser Arg His Phe Leu Ser Ile Phe Ser Ser Ala 
145                 150                 155                 160 


Lys Glu Arg Thr Leu Cys Arg Ser Ser Leu Glu Leu Leu Leu Glu Ala 
                165                 170                 175     


Tyr Phe Cys Gly Arg Val Gly Arg Asn Asn His Lys Phe Ile Ser Gln 
            180                 185                 190         


Leu Met Cys Asp Tyr Phe Phe Lys Cys Met Thr Cys Lys Ser Gly Ile 
        195                 200                 205             


Gly Val Phe Glu Leu Val Asp Asp His Phe Val Glu Leu Asn Val Gly 
    210                 215                 220                 


Val Thr Gly Leu Pro Val Ser Asp Ser Arg Ile Ile Ala Gly Leu Val 
225                 230                 235                 240 


Leu Gln Lys Asp Phe Ser Val Tyr Arg Pro Ala Asp Gly Asp Met Arg 
                245                 250                 255     


Met Val Ile Val Thr Glu Thr Ile Gln Pro Leu Phe Ser Thr Ser Gly 
            260                 265                 270         


Ser Glu Phe Ile Leu Asn Ser Glu Ala Gln Phe Gln Thr Ser Gln Phe 
        275                 280                 285             


Trp Ile Met Glu Lys Thr Lys Ala Ile Met Lys His Leu His Ser Gln 
    290                 295                 300                 


Asn Val Lys Leu Leu Ile Ser Ser Val Lys Gln Pro Asp Leu Val Ser 
305                 310                 315                 320 


Tyr Tyr Ala Gly Val Asn Gly Ile Ser Val Val Glu Cys Leu Ser Ser 
                325                 330                 335     


Glu Glu Val Ser Leu Ile Arg Arg Ile Ile Gly Leu Ser Pro Phe Val 
            340                 345                 350         


Pro Pro Gln Ala Phe Ser Gln Cys Glu Ile Pro Asn Thr Ala Leu Val 
        355                 360                 365             


Lys Phe Cys Lys Pro Leu Ile Leu Arg Ser Lys Arg Tyr Val His Leu 
    370                 375                 380                 


Gly Leu Ile Ser Thr Cys Ala Phe Ile Pro His Ser Ile Val Leu Cys 
385                 390                 395                 400 


Gly Pro Val His Gly Leu Ile Glu Gln His Glu Asp Ala Leu His Gly 
                405                 410                 415     


Ala Leu Lys Met Leu Arg Gln Leu Phe Lys Asp Leu Asp Leu Asn Tyr 
            420                 425                 430         


Met Thr Gln Thr Asn Asp Gln Asn Gly Thr Ser Ser Leu Phe Ile Tyr 
        435                 440                 445             


Lys Asn Ser Gly Glu Ser Tyr Gln Ala Pro Asp Pro Gly Asn Gly Ser 
    450                 455                 460                 


Ile Gln Arg Pro Tyr Gln Asp Thr Val Ala Glu Asn Lys Asp Ala Leu 
465                 470                 475                 480 


Glu Lys Thr Gln Thr Tyr Leu Lys Val His Ser Asn Leu Val Ile Pro 
                485                 490                 495     


Asp Val Glu Leu Glu Thr Tyr Ile Pro Tyr Ser Thr Pro Thr Leu Thr 
            500                 505                 510         


Pro Thr Asp Thr Phe Gln Thr Val Glu Thr Leu Thr Cys Leu Ser Leu 
        515                 520                 525             


Glu Arg Asn Arg Leu Thr Asp Tyr Tyr Glu Pro Leu Leu Lys Asn Asn 
    530                 535                 540                 


Ser Thr Ala Tyr Ser Thr Arg Gly Asn Arg Ile Glu Ile Ser Tyr Glu 
545                 550                 555                 560 


Asn Leu Gln Val Thr Asn Ile Thr Arg Lys Gly Ser Met Leu Pro Val 
                565                 570                 575     


Ser Cys Lys Leu Pro Asn Met Gly Thr Ser Gln Ser Tyr Leu Ser Ser 
            580                 585                 590         


Ser Met Pro Ala Gly Cys Val Leu Pro Val Gly Gly Asn Phe Glu Ile 
        595                 600                 605             


Leu Leu His Tyr Tyr Leu Leu Asn Tyr Ala Lys Lys Cys His Gln Ser 
    610                 615                 620                 


Glu Glu Thr Met Val Ser Met Ile Ile Ala Asn Ala Leu Leu Gly Ile 
625                 630                 635                 640 


Pro Lys Val Leu Tyr Lys Ser Lys Thr Gly Lys Tyr Ser Phe Pro His 
                645                 650                 655     


Thr Tyr Ile Arg Ala Val His Ala Leu Gln Thr Asn Gln Pro Leu Val 
            660                 665                 670         


Ser Ser Gln Thr Gly Leu Glu Ser Val Met Gly Lys Tyr Gln Leu Leu 
        675                 680                 685             


Thr Ser Val Leu Gln Cys Leu Thr Lys Ile Leu Thr Ile Asp Met Val 
    690                 695                 700                 


Ile Thr Val Lys Arg His Pro Gln Lys Val His Asn Gln Asp Ser Glu 
705                 710                 715                 720 


Asp Glu Leu 
            


<210>  2990
<211>  7213
<212>  DNA
<213>  Homosapiens

<400>  2990
cactagaatg tgaaggatct tcgcggttct gggtgcccag aaaggcggcg acgcggcgga     60

tgacaacatt aggccgcgac gcgctcctgg ccaggcggcg gctgtagtgt tagctttgga    120

cgccgcagta gccgctgccg gtagcaagcc gactgaggga aggtgggggt ccgcccgggc    180

tggtggacct cggggccgaa agttcccgcc ccgctcgggg gctgagccgg cagtgcctcc    240

gcggccgctg ggcagcgccc ttcgtccagg ctcgcgcccc agctgccgcc gacgacagcg    300

gccgagagaa gttggggtct gactagacgc ttacggggcc tcggaccccg gcgccgcggc    360

gacctcggag gaaccggctc cttgcgtccc gcctccctgg gagctccgca cgggatttgc    420

agatttacag aatggctgca cattaatgga aagagaagca taaacctatc ttctttcatt    480

atggagggag gtttggcaga tggagaacct gatcgaactt cgcaaacagt gacgaatctc    540

agcttctgac accaggaaag atgagtcagc gccaaggaaa agaagcttat ccaacgccaa    600

ccaaagattt gcatcagcca tctcttagtc cagcaagtcc tcatagccag ggttttgaaa    660

gagggaagga agatatttct caaaataaag atgaatcttc actttctatg tcaaagagca    720

agtctgaatc taaactttat aatggctcag agaaggacag ttcaacttca agcaaactca    780

caaaaaaaga atctcttaag gtacaaaaga aaaattaccg agaagaaaag aaaagagcca    840

caaaggagct gctcagtaca atcacagatc cttctgttat tgttatggct gattggttaa    900

agattcgtgg tactctaaag agctggacca agttatggtg tgtgttgaaa cctggggtgc    960

tactgatcta taaaacccaa aaaaatggtc agtgggtagg aacagttctt ctgaatgcct   1020

gtgaaatcat tgaacgtcca tcaaaaaagg atggcttttg tttcaaactt ttccatcctt   1080

tggagcaatc tatttgggca gtgaagggtc caaaaggtga agcggttgga tccattactc   1140

aacccttacc tagcagttat ttgatcatcc gagctacttc agagtcagat ggaaggtgct   1200

ggatggatgc tttggagttg gctttgaaat gttctagtct tcttaaacgt acaatgatca   1260

gagaaggaaa ggaacatgac ctgagcgttt catcagatag cacacatgtg actttctatg   1320

gcttactacg tgctaacaat ctccacagtg gtgataactt ccagttaaat gatagtgaaa   1380

ttgaacgaca acattttaag gaccaagata tgtattctga taaatctgat aaagaaaatg   1440

atcaagaaca tgatgagtct gataatgagg tgatggggaa aagtgaagaa agtgacacag   1500

atacatcaga aagacaagat gactcatata tcgaacctga gcctgttgag cctttaaagg   1560

agactaccta cactgaacag agccatgaag aacttggaga ggcaggtgag gcttctcaaa   1620

cagaaactgt atctgaagaa aacaaaagcc ttatctggac actattgaaa caagtccgtc   1680

ctggcatgga cctatccaag gtggttctgc ctacatttat tttggaaccc cgttctttcc   1740

tggataaact ttcagattac tactatcatg cagatttcct atctgaggca gctcttgaag   1800

aaaatcctta tttccgtttg aagaaagtag tgaaatggta tttgtcagga ttctataaaa   1860

agccaaaggg actgaagaaa ccttataatc ctatacttgg cgagactttc cgttgtttat   1920

ggattcatcc cagaacaaac agcaaaactt tttatattgc tgaacaggtg tcccatcatc   1980

caccaatatc tgccttttat gttagtaatc gaaaagatgg attttgcctt agcggtagta   2040

tcctggctaa gtctaagttt tatggaaact cattatctgc aatattagag ggagaagcac   2100

ggttaacttt cttgaataga ggtgaagatt atgtaatgac aatgccatac gctcattgta   2160

aaggaattct ttatggtaca atgacactgg agcttggtgg aacagtcaat attacatgtc   2220

aaaaaactgg atacagtgca atacttgaat ttaaactaaa gccattccta gggagtagtg   2280

actgtgttaa tcaaatatca gggaaactta aactgggaaa agaagtccta gctactttgg   2340

aaggtcattg ggatagtgaa gtttttatta ctgataaaaa gactgataat tcagaggttt   2400

tctggaatcc aacacctgac attaagcaat ggagattaat aaggcacact gtaaaatttg   2460

aagaacaggg agattttgaa tcagagaaac tctggcaacg ggtaactcga gccataaatg   2520

ccaaagacca aactgaagct acccaagaga agtatgtttt ggaagaagct caaagacaag   2580

ctgccaggga tcggaaaaca aaaaatgaag agtggtcttg caaattattt gaacttgatc   2640

cactcacagg agaatggcat tacaagtttg cagatacccg accatgggac ccacttaatg   2700

atatgataca gtttgaaaaa gatggtgtta ttcagaccaa agtgaaacat cgtactccaa   2760

tggttagcgt ccccaaaatg aaacataagc caaccaggca acagaagaaa gtagcaaaag   2820

gctattcctc cccagaacct gacattcaag actcctctgg aagtgaagct caatcagtaa   2880

aaccaagtac aagaagaaag aaaggaatag aactgggaga cattcagagt tccatcgaat   2940

ctataaaaca aacacaggaa gaaattaaaa gaaatattat ggctcttcga aatcatttag   3000

tttcaagcac accggccacg gattattttc tgcaacaaaa agactacttc atcattttcc   3060

tcctgatttt gcttcaagtc ataataaact tcatgttcaa gtagaagttc tctaccattg   3120

aatcagtgaa ctagaaagat ctgatttggc ctgggaccag tgttcaagtt ggtttggtct   3180

ttattaaaaa tcacaatatt ccgaaaacaa aaaaacctag gagataaatg tagaggtatt   3240

gacttttcgt atcttttatc ttcacactga aacaagagct atcctatttg attattaaag   3300

tgagctatgt gttaagtgcc aggacatttc tagcttttgt gagaatgtgt ctacatatga   3360

gtataataaa cccacatgta tacacaattg tctcttatgt actcctacct gacagtagtc   3420

tttgtattct atagtatgtt ctgagatata atgttaacat tgttcataac aaaaaatgct   3480

atcaatctta taaatatatg taatctattt tcttcataaa acaggcacaa aagttttatc   3540

agtaaggaat tacagattga gaaatgatgg aataatagac ataattaatt caatacacta   3600

ctgttaaaat catttgcaaa gcactcagct caattatctt cttagaaaga aagaaaaagt   3660

atgaatggtc aaaatgaata catcgagaga gataaatggc aaattgcttt tttaaaagtt   3720

tacataagtt ttttttaacc cctagaattt aatatttgta gatgcaggta aatatatata   3780

cttacgtgta tatcagtata aaaacactgg tgtgcaatta attggattga ttataatacc   3840

accttaagca cttgctgaaa aaagtgtggt caaaattgat tgctgtcctt ttgtcttatt   3900

tttgtttttc ttaagtcagc tggttcataa cataggccaa attctagaga tgtttataga   3960

gcatttgaag tgctgataat ttatgttttt tcattatgaa aacttatttt agctttagac   4020

tccagtgtgt tcagtgaata agtagaatat aaaaaaatat aaccagtatt ttacttcaaa   4080

agccaaaaag aggcaataag aaaagacact ttgtggtggc ctttatgtgt gcattaaaat   4140

tggtttctgt aaaacgtgta ataagttgag tatctacgaa gagtatcaag ttctgaagtt   4200

taattttttt attatcctcc tctcttctta gtaacttctt tctgtggcaa aaccacaatt   4260

ctttaagatt cctattgttc aggctaaggc aaattttttt gtttgtttct tcagtttaat   4320

attttgattt tgtgttttta cgtaaatatt tatattcctt gaaagcaatt tttgccaagg   4380

tagttcagtt taggaatatg ttgttctaaa atatgtctta gaatcctgaa agcatagatt   4440

ttgaaatgtt tttttaatga aaatgaaggt cagagagaat aattgccctg accacatttg   4500

cctttcagta ggaggaggct gtgaaatagt aaaattataa tcgtttatgc catgataaat   4560

acaagattgg taaataaata cattgattgg taaattatga gaatcaaaat gataaaaaga   4620

gcctgctttt ttccctaacc aatatagcta tcttaagtat ccttaggttt ctgtgaagaa   4680

ccatttccca tgttttcttg gcaaaataat gctgtattcc atatgtacat gtgaaatgat   4740

gttttaaatt gataaaagct taaataagat ctacctatac ccagtatttt catgatatta   4800

gaacaaatgg gtttttggtt atattttata tttgtcaata taatttttgt attcacattc   4860

tgttacactc tgcctattca ttgatatatg atattctgta aatattgtac aatttgatct   4920

tttttatggt ttaaattagt taattacata caaattgatt ggcttatcac aaaaatcatt   4980

tcatcagtaa accttgttaa cattttgtac tggtgaccca cctcttagga ctttggtctt   5040

atccacgtgt atgttgtttt catttggtcc aaataatatt ttatttgtat gggtatcttc   5100

taagactaaa taggtagttg tgttctttat ttttaaaatt tctttttaga gcaaatgtta   5160

tgggttctta cccaaagagt caaaaactat ttcttaagaa agagcagagt tattcatgac   5220

tgttctttat acactaaaag catgcatcta atctaatagt cctcttatta tgcttttagt   5280

tgtatgagtc tctttctatg aactgaacac aaaactcagg aattggtggc ttaattttag   5340

atcagtgctt gtactaggct tagttatatg aatctttata acacataatt actaactttg   5400

tagccatata tgtaattgac tttgaatgtt atttacctga aattaatctt ccttcacaca   5460

tggaccgtaa acggttccca gttgtctgag agcctcatga gggtttctag gatttatgac   5520

cttatgacca gtttttttca tttaccaaga ttttattttc ctacatgaaa atttaattga   5580

gtaataatta ttcacatgtg cattttcttt ttagctgtta aatgtactat gccatcatcc   5640

accatttagt aaaatgtagc tggcccagga catgtaaaaa aaaaaaaaaa acaacaacaa   5700

taaatagggc atgtgaaatg ttaagttaca gcaatagata ttttatttgt atttcatgtt   5760

agtacttttt tgttttatat cacttataaa ggtacagtgt actctttgtc acagctcagt   5820

tggtaaccgc attccattga aaagttggcc ttgtaaaata caactctcat ttaatattca   5880

tgcttttgtg cctttaagaa aatatttttt gtcatttttt gtgttacaga actataatgt   5940

gattcaaggt gtttataggc ttgtcataaa agggtcattt ctgtgtgtta ctttcttttt   6000

atatagctat agtatattta aacaataata ctatctttta taggggtttg tctatttacc   6060

tattctttac tcagacattg atgtagactt gtcagattat tctgagtatt gttaacagtg   6120

ccttttcgat ggaatcacac tttttggctg tcaccttgtg ccatatacac acaaaatttt   6180

gtggaaggca gttttaactt tctgaagaat atctgtcaaa atttaagaaa acaaatgtat   6240

aaaattccat tttttccagt gtttagcatt tctagtaagc agtgaggttg tttgacatac   6300

agtgatgatg gcattattga taagccatac atgagactgc agattatatt gaatcatatt   6360

aaatgtacag aaataaaata ttagatttat atcaaatttt ccaatttgaa ccagtgggga   6420

aaatcccaca gaaatcagta agtttacatt tcaatttcta tcttatttga ctaagtggaa   6480

agagattctt taaaatgtat aacctgccat tatgtaattt ggtttcattt tattctacct   6540

gttgtgtgag tttagtatat ttaatttact ttttgttact ctttacatac tgtttatttt   6600

tgttagtttt taattgaaga tggactgttg aaattgtata ggaccagtgt cttattaata   6660

tgattaatat atttagaaga gccacgtgaa acccatgaca aaatgaatgt gaatattctt   6720

tctaaaaatt tagaaaatgt tatctttttg catttattat gtaaaactgt tttacagtat   6780

caaaattttt cacttaaaga aaaaaaatgc catgaaacat ttgaactgat gagccacaga   6840

acttcagttg aaattttttt cactttttag catgctaaat atacatctga gtttaaatgt   6900

tctgtttaat ggccattcat aaattcaagc actaccactg gtcagttttg tgtgatagaa   6960

taaaaatatg ttacctgcag tgtaagtaca gcacactgtc aaattctttt ccttaaggtg   7020

cacagtaaat gtacagatag ttataggcca ctgttttgta atgtagtaca tttctaatct   7080

attattccta acctattata actgtttgca gaaagaaaag aatttttcta ataatctgta   7140

aaattatgct aacttctaca agtaggcttc taaataaaat ttttaaaaag agcaaaaaaa   7200

aaaaaaaaaa aaa                                                      7213


<210>  2991
<211>  847
<212>  PRT
<213>  Homosapiens

<400>  2991

Met Ser Gln Arg Gln Gly Lys Glu Ala Tyr Pro Thr Pro Thr Lys Asp 
1               5                   10                  15      


Leu His Gln Pro Ser Leu Ser Pro Ala Ser Pro His Ser Gln Gly Phe 
            20                  25                  30          


Glu Arg Gly Lys Glu Asp Ile Ser Gln Asn Lys Asp Glu Ser Ser Leu 
        35                  40                  45              


Ser Met Ser Lys Ser Lys Ser Glu Ser Lys Leu Tyr Asn Gly Ser Glu 
    50                  55                  60                  


Lys Asp Ser Ser Thr Ser Ser Lys Leu Thr Lys Lys Glu Ser Leu Lys 
65                  70                  75                  80  


Val Gln Lys Lys Asn Tyr Arg Glu Glu Lys Lys Arg Ala Thr Lys Glu 
                85                  90                  95      


Leu Leu Ser Thr Ile Thr Asp Pro Ser Val Ile Val Met Ala Asp Trp 
            100                 105                 110         


Leu Lys Ile Arg Gly Thr Leu Lys Ser Trp Thr Lys Leu Trp Cys Val 
        115                 120                 125             


Leu Lys Pro Gly Val Leu Leu Ile Tyr Lys Thr Gln Lys Asn Gly Gln 
    130                 135                 140                 


Trp Val Gly Thr Val Leu Leu Asn Ala Cys Glu Ile Ile Glu Arg Pro 
145                 150                 155                 160 


Ser Lys Lys Asp Gly Phe Cys Phe Lys Leu Phe His Pro Leu Glu Gln 
                165                 170                 175     


Ser Ile Trp Ala Val Lys Gly Pro Lys Gly Glu Ala Val Gly Ser Ile 
            180                 185                 190         


Thr Gln Pro Leu Pro Ser Ser Tyr Leu Ile Ile Arg Ala Thr Ser Glu 
        195                 200                 205             


Ser Asp Gly Arg Cys Trp Met Asp Ala Leu Glu Leu Ala Leu Lys Cys 
    210                 215                 220                 


Ser Ser Leu Leu Lys Arg Thr Met Ile Arg Glu Gly Lys Glu His Asp 
225                 230                 235                 240 


Leu Ser Val Ser Ser Asp Ser Thr His Val Thr Phe Tyr Gly Leu Leu 
                245                 250                 255     


Arg Ala Asn Asn Leu His Ser Gly Asp Asn Phe Gln Leu Asn Asp Ser 
            260                 265                 270         


Glu Ile Glu Arg Gln His Phe Lys Asp Gln Asp Met Tyr Ser Asp Lys 
        275                 280                 285             


Ser Asp Lys Glu Asn Asp Gln Glu His Asp Glu Ser Asp Asn Glu Val 
    290                 295                 300                 


Met Gly Lys Ser Glu Glu Ser Asp Thr Asp Thr Ser Glu Arg Gln Asp 
305                 310                 315                 320 


Asp Ser Tyr Ile Glu Pro Glu Pro Val Glu Pro Leu Lys Glu Thr Thr 
                325                 330                 335     


Tyr Thr Glu Gln Ser His Glu Glu Leu Gly Glu Ala Gly Glu Ala Ser 
            340                 345                 350         


Gln Thr Glu Thr Val Ser Glu Glu Asn Lys Ser Leu Ile Trp Thr Leu 
        355                 360                 365             


Leu Lys Gln Val Arg Pro Gly Met Asp Leu Ser Lys Val Val Leu Pro 
    370                 375                 380                 


Thr Phe Ile Leu Glu Pro Arg Ser Phe Leu Asp Lys Leu Ser Asp Tyr 
385                 390                 395                 400 


Tyr Tyr His Ala Asp Phe Leu Ser Glu Ala Ala Leu Glu Glu Asn Pro 
                405                 410                 415     


Tyr Phe Arg Leu Lys Lys Val Val Lys Trp Tyr Leu Ser Gly Phe Tyr 
            420                 425                 430         


Lys Lys Pro Lys Gly Leu Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu 
        435                 440                 445             


Thr Phe Arg Cys Leu Trp Ile His Pro Arg Thr Asn Ser Lys Thr Phe 
    450                 455                 460                 


Tyr Ile Ala Glu Gln Val Ser His His Pro Pro Ile Ser Ala Phe Tyr 
465                 470                 475                 480 


Val Ser Asn Arg Lys Asp Gly Phe Cys Leu Ser Gly Ser Ile Leu Ala 
                485                 490                 495     


Lys Ser Lys Phe Tyr Gly Asn Ser Leu Ser Ala Ile Leu Glu Gly Glu 
            500                 505                 510         


Ala Arg Leu Thr Phe Leu Asn Arg Gly Glu Asp Tyr Val Met Thr Met 
        515                 520                 525             


Pro Tyr Ala His Cys Lys Gly Ile Leu Tyr Gly Thr Met Thr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Thr Val Asn Ile Thr Cys Gln Lys Thr Gly Tyr Ser Ala 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Lys Pro Phe Leu Gly Ser Ser Asp Cys Val 
                565                 570                 575     


Asn Gln Ile Ser Gly Lys Leu Lys Leu Gly Lys Glu Val Leu Ala Thr 
            580                 585                 590         


Leu Glu Gly His Trp Asp Ser Glu Val Phe Ile Thr Asp Lys Lys Thr 
        595                 600                 605             


Asp Asn Ser Glu Val Phe Trp Asn Pro Thr Pro Asp Ile Lys Gln Trp 
    610                 615                 620                 


Arg Leu Ile Arg His Thr Val Lys Phe Glu Glu Gln Gly Asp Phe Glu 
625                 630                 635                 640 


Ser Glu Lys Leu Trp Gln Arg Val Thr Arg Ala Ile Asn Ala Lys Asp 
                645                 650                 655     


Gln Thr Glu Ala Thr Gln Glu Lys Tyr Val Leu Glu Glu Ala Gln Arg 
            660                 665                 670         


Gln Ala Ala Arg Asp Arg Lys Thr Lys Asn Glu Glu Trp Ser Cys Lys 
        675                 680                 685             


Leu Phe Glu Leu Asp Pro Leu Thr Gly Glu Trp His Tyr Lys Phe Ala 
    690                 695                 700                 


Asp Thr Arg Pro Trp Asp Pro Leu Asn Asp Met Ile Gln Phe Glu Lys 
705                 710                 715                 720 


Asp Gly Val Ile Gln Thr Lys Val Lys His Arg Thr Pro Met Val Ser 
                725                 730                 735     


Val Pro Lys Met Lys His Lys Pro Thr Arg Gln Gln Lys Lys Val Ala 
            740                 745                 750         


Lys Gly Tyr Ser Ser Pro Glu Pro Asp Ile Gln Asp Ser Ser Gly Ser 
        755                 760                 765             


Glu Ala Gln Ser Val Lys Pro Ser Thr Arg Arg Lys Lys Gly Ile Glu 
    770                 775                 780                 


Leu Gly Asp Ile Gln Ser Ser Ile Glu Ser Ile Lys Gln Thr Gln Glu 
785                 790                 795                 800 


Glu Ile Lys Arg Asn Ile Met Ala Leu Arg Asn His Leu Val Ser Ser 
                805                 810                 815     


Thr Pro Ala Thr Asp Tyr Phe Leu Gln Gln Lys Asp Tyr Phe Ile Ile 
            820                 825                 830         


Phe Leu Leu Ile Leu Leu Gln Val Ile Ile Asn Phe Met Phe Lys 
        835                 840                 845         


<210>  2992
<211>  7259
<212>  DNA
<213>  Homosapiens

<400>  2992
cactagaatg tgaaggatct tcgcggttct gggtgcccag aaaggcggcg acgcggcgga     60

tgacaacatt aggccgcgac gcgctcctgg ccaggcggcg gctgtagtgt tagctttgga    120

cgccgcagta gccgctgccg gtagcaagcc gactgaggga aggtgggggt ccgcccgggc    180

tggtggacct cggggccgaa agttcccgcc ccgctcgggg gctgagccgg cagtgcctcc    240

gcggccgctg ggcagcgccc ttcgtccagg ctcgcgcccc agctgccgcc gacgacagcg    300

gccgagagaa gttggggtct gactagacgc ttacggggcc tcggaccccg gcgccgcggc    360

gacctcggag gaaccggctc cttgcgtccc gcctccctgg gagctccgca cgggatttgc    420

agatttacag aatggctgca cattaatgga aagagaagca taaacctatc ttctttcatt    480

atggagggag gtttggcaga tggagaacct gatcgaactt cgcttcttgg tgatagcaaa    540

gatgtccttg ggccatcaac tgttgtagca aacagtgacg aatctcagct tctgacacca    600

ggaaagatga gtcagcgcca aggaaaagaa gcttatccaa cgccaaccaa agatttgcat    660

cagccatctc ttagtccagc aagtcctcat agccagggtt ttgaaagagg gaaggaagat    720

atttctcaaa ataaagatga atcttcactt tctatgtcaa agagcaagtc tgaatctaaa    780

ctttataatg gctcagagaa ggacagttca acttcaagca aactcacaaa aaaagaatct    840

cttaaggtac aaaagaaaaa ttaccgagaa gaaaagaaaa gagccacaaa ggagctgctc    900

agtacaatca cagatccttc tgttattgtt atggctgatt ggttaaagat tcgtggtact    960

ctaaagagct ggaccaagtt atggtgtgtg ttgaaacctg gggtgctact gatctataaa   1020

acccaaaaaa atggtcagtg ggtaggaaca gttcttctga atgcctgtga aatcattgaa   1080

cgtccatcaa aaaaggatgg cttttgtttc aaacttttcc atcctttgga gcaatctatt   1140

tgggcagtga agggtccaaa aggtgaagcg gttggatcca ttactcaacc cttacctagc   1200

agttatttga tcatccgagc tacttcagag tcagatggaa ggtgctggat ggatgctttg   1260

gagttggctt tgaaatgttc tagtcttctt aaacgtacaa tgatcagaga aggaaaggaa   1320

catgacctga gcgtttcatc agatagcaca catgtgactt tctatggctt actacgtgct   1380

aacaatctcc acagtggtga taacttccag ttaaatgata gtgaaattga acgacaacat   1440

tttaaggacc aagatatgta ttctgataaa tctgataaag aaaatgatca agaacatgat   1500

gagtctgata atgaggtgat ggggaaaagt gaagaaagtg acacagatac atcagaaaga   1560

caagatgact catatatcga acctgagcct gttgagcctt taaaggagac tacctacact   1620

gaacagagcc atgaagaact tggagaggca ggtgaggctt ctcaaacaga aactgtatct   1680

gaagaaaaca aaagccttat ctggacacta ttgaaacaag tccgtcctgg catggaccta   1740

tccaaggtgg ttctgcctac atttattttg gaaccccgtt ctttcctgga taaactttca   1800

gattactact atcatgcaga tttcctatct gaggcagctc ttgaagaaaa tccttatttc   1860

cgtttgaaga aagtagtgaa atggtatttg tcaggattct ataaaaagcc aaagggactg   1920

aagaaacctt ataatcctat acttggcgag actttccgtt gtttatggat tcatcccaga   1980

acaaacagca aaacttttta tattgctgaa caggtgtccc atcatccacc aatatctgcc   2040

ttttatgtta gtaatcgaaa agatggattt tgccttagcg gtagtatcct ggctaagtct   2100

aagttttatg gaaactcatt atctgcaata ttagagggag aagcacggtt aactttcttg   2160

aatagaggtg aagattatgt aatgacaatg ccatacgctc attgtaaagg aattctttat   2220

ggtacaatga cactggagct tggtggaaca gtcaatatta catgtcaaaa aactggatac   2280

agtgcaatac ttgaatttaa actaaagcca ttcctaggga gtagtgactg tgttaatcaa   2340

atatcaggga aacttaaact gggaaaagaa gtcctagcta ctttggaagg tcattgggat   2400

agtgaagttt ttattactga taaaaagact gataattcag aggttttctg gaatccaaca   2460

cctgacatta agcaatggag attaataagg cacactgtaa aatttgaaga acagggagat   2520

tttgaatcag agaaactctg gcaacgggta actcgagcca taaatgccaa agaccaaact   2580

gaagctaccc aagagaagta tgttttggaa gaagctcaaa gacaagctgc cagggatcgg   2640

aaaacaaaaa atgaagagtg gtcttgcaaa ttatttgaac ttgatccact cacaggagaa   2700

tggcattaca agtttgcaga tacccgacca tgggacccac ttaatgatat gatacagttt   2760

gaaaaagatg gtgttattca gaccaaagtg aaacatcgta ctccaatggt tagcgtcccc   2820

aaaatgaaac ataagccaac caggcaacag aagaaagtag caaaaggcta ttcctcccca   2880

gaacctgaca ttcaagactc ctctggaagt gaagctcaat cagtaaaacc aagtacaaga   2940

agaaagaaag gaatagaact gggagacatt cagagttcca tcgaatctat aaaacaaaca   3000

caggaagaaa ttaaaagaaa tattatggct cttcgaaatc atttagtttc aagcacaccg   3060

gccacggatt attttctgca acaaaaagac tacttcatca ttttcctcct gattttgctt   3120

caagtcataa taaacttcat gttcaagtag aagttctcta ccattgaatc agtgaactag   3180

aaagatctga tttggcctgg gaccagtgtt caagttggtt tggtctttat taaaaatcac   3240

aatattccga aaacaaaaaa acctaggaga taaatgtaga ggtattgact tttcgtatct   3300

tttatcttca cactgaaaca agagctatcc tatttgatta ttaaagtgag ctatgtgtta   3360

agtgccagga catttctagc ttttgtgaga atgtgtctac atatgagtat aataaaccca   3420

catgtataca caattgtctc ttatgtactc ctacctgaca gtagtctttg tattctatag   3480

tatgttctga gatataatgt taacattgtt cataacaaaa aatgctatca atcttataaa   3540

tatatgtaat ctattttctt cataaaacag gcacaaaagt tttatcagta aggaattaca   3600

gattgagaaa tgatggaata atagacataa ttaattcaat acactactgt taaaatcatt   3660

tgcaaagcac tcagctcaat tatcttctta gaaagaaaga aaaagtatga atggtcaaaa   3720

tgaatacatc gagagagata aatggcaaat tgctttttta aaagtttaca taagtttttt   3780

ttaaccccta gaatttaata tttgtagatg caggtaaata tatatactta cgtgtatatc   3840

agtataaaaa cactggtgtg caattaattg gattgattat aataccacct taagcacttg   3900

ctgaaaaaag tgtggtcaaa attgattgct gtccttttgt cttatttttg tttttcttaa   3960

gtcagctggt tcataacata ggccaaattc tagagatgtt tatagagcat ttgaagtgct   4020

gataatttat gttttttcat tatgaaaact tattttagct ttagactcca gtgtgttcag   4080

tgaataagta gaatataaaa aaatataacc agtattttac ttcaaaagcc aaaaagaggc   4140

aataagaaaa gacactttgt ggtggccttt atgtgtgcat taaaattggt ttctgtaaaa   4200

cgtgtaataa gttgagtatc tacgaagagt atcaagttct gaagtttaat ttttttatta   4260

tcctcctctc ttcttagtaa cttctttctg tggcaaaacc acaattcttt aagattccta   4320

ttgttcaggc taaggcaaat ttttttgttt gtttcttcag tttaatattt tgattttgtg   4380

tttttacgta aatatttata ttccttgaaa gcaatttttg ccaaggtagt tcagtttagg   4440

aatatgttgt tctaaaatat gtcttagaat cctgaaagca tagattttga aatgtttttt   4500

taatgaaaat gaaggtcaga gagaataatt gccctgacca catttgcctt tcagtaggag   4560

gaggctgtga aatagtaaaa ttataatcgt ttatgccatg ataaatacaa gattggtaaa   4620

taaatacatt gattggtaaa ttatgagaat caaaatgata aaaagagcct gcttttttcc   4680

ctaaccaata tagctatctt aagtatcctt aggtttctgt gaagaaccat ttcccatgtt   4740

ttcttggcaa aataatgctg tattccatat gtacatgtga aatgatgttt taaattgata   4800

aaagcttaaa taagatctac ctatacccag tattttcatg atattagaac aaatgggttt   4860

ttggttatat tttatatttg tcaatataat ttttgtattc acattctgtt acactctgcc   4920

tattcattga tatatgatat tctgtaaata ttgtacaatt tgatcttttt tatggtttaa   4980

attagttaat tacatacaaa ttgattggct tatcacaaaa atcatttcat cagtaaacct   5040

tgttaacatt ttgtactggt gacccacctc ttaggacttt ggtcttatcc acgtgtatgt   5100

tgttttcatt tggtccaaat aatattttat ttgtatgggt atcttctaag actaaatagg   5160

tagttgtgtt ctttattttt aaaatttctt tttagagcaa atgttatggg ttcttaccca   5220

aagagtcaaa aactatttct taagaaagag cagagttatt catgactgtt ctttatacac   5280

taaaagcatg catctaatct aatagtcctc ttattatgct tttagttgta tgagtctctt   5340

tctatgaact gaacacaaaa ctcaggaatt ggtggcttaa ttttagatca gtgcttgtac   5400

taggcttagt tatatgaatc tttataacac ataattacta actttgtagc catatatgta   5460

attgactttg aatgttattt acctgaaatt aatcttcctt cacacatgga ccgtaaacgg   5520

ttcccagttg tctgagagcc tcatgagggt ttctaggatt tatgacctta tgaccagttt   5580

ttttcattta ccaagatttt attttcctac atgaaaattt aattgagtaa taattattca   5640

catgtgcatt ttctttttag ctgttaaatg tactatgcca tcatccacca tttagtaaaa   5700

tgtagctggc ccaggacatg taaaaaaaaa aaaaaaacaa caacaataaa tagggcatgt   5760

gaaatgttaa gttacagcaa tagatatttt atttgtattt catgttagta cttttttgtt   5820

ttatatcact tataaaggta cagtgtactc tttgtcacag ctcagttggt aaccgcattc   5880

cattgaaaag ttggccttgt aaaatacaac tctcatttaa tattcatgct tttgtgcctt   5940

taagaaaata ttttttgtca ttttttgtgt tacagaacta taatgtgatt caaggtgttt   6000

ataggcttgt cataaaaggg tcatttctgt gtgttacttt ctttttatat agctatagta   6060

tatttaaaca ataatactat cttttatagg ggtttgtcta tttacctatt ctttactcag   6120

acattgatgt agacttgtca gattattctg agtattgtta acagtgcctt ttcgatggaa   6180

tcacactttt tggctgtcac cttgtgccat atacacacaa aattttgtgg aaggcagttt   6240

taactttctg aagaatatct gtcaaaattt aagaaaacaa atgtataaaa ttccattttt   6300

tccagtgttt agcatttcta gtaagcagtg aggttgtttg acatacagtg atgatggcat   6360

tattgataag ccatacatga gactgcagat tatattgaat catattaaat gtacagaaat   6420

aaaatattag atttatatca aattttccaa tttgaaccag tggggaaaat cccacagaaa   6480

tcagtaagtt tacatttcaa tttctatctt atttgactaa gtggaaagag attctttaaa   6540

atgtataacc tgccattatg taatttggtt tcattttatt ctacctgttg tgtgagttta   6600

gtatatttaa tttacttttt gttactcttt acatactgtt tatttttgtt agtttttaat   6660

tgaagatgga ctgttgaaat tgtataggac cagtgtctta ttaatatgat taatatattt   6720

agaagagcca cgtgaaaccc atgacaaaat gaatgtgaat attctttcta aaaatttaga   6780

aaatgttatc tttttgcatt tattatgtaa aactgtttta cagtatcaaa atttttcact   6840

taaagaaaaa aaatgccatg aaacatttga actgatgagc cacagaactt cagttgaaat   6900

ttttttcact ttttagcatg ctaaatatac atctgagttt aaatgttctg tttaatggcc   6960

attcataaat tcaagcacta ccactggtca gttttgtgtg atagaataaa aatatgttac   7020

ctgcagtgta agtacagcac actgtcaaat tcttttcctt aaggtgcaca gtaaatgtac   7080

agatagttat aggccactgt tttgtaatgt agtacatttc taatctatta ttcctaacct   7140

attataactg tttgcagaaa gaaaagaatt tttctaataa tctgtaaaat tatgctaact   7200

tctacaagta ggcttctaaa taaaattttt aaaaagagca aaaaaaaaaa aaaaaaaaa    7259


<210>  2993
<211>  889
<212>  PRT
<213>  Homosapiens

<400>  2993

Met Glu Gly Gly Leu Ala Asp Gly Glu Pro Asp Arg Thr Ser Leu Leu 
1               5                   10                  15      


Gly Asp Ser Lys Asp Val Leu Gly Pro Ser Thr Val Val Ala Asn Ser 
            20                  25                  30          


Asp Glu Ser Gln Leu Leu Thr Pro Gly Lys Met Ser Gln Arg Gln Gly 
        35                  40                  45              


Lys Glu Ala Tyr Pro Thr Pro Thr Lys Asp Leu His Gln Pro Ser Leu 
    50                  55                  60                  


Ser Pro Ala Ser Pro His Ser Gln Gly Phe Glu Arg Gly Lys Glu Asp 
65                  70                  75                  80  


Ile Ser Gln Asn Lys Asp Glu Ser Ser Leu Ser Met Ser Lys Ser Lys 
                85                  90                  95      


Ser Glu Ser Lys Leu Tyr Asn Gly Ser Glu Lys Asp Ser Ser Thr Ser 
            100                 105                 110         


Ser Lys Leu Thr Lys Lys Glu Ser Leu Lys Val Gln Lys Lys Asn Tyr 
        115                 120                 125             


Arg Glu Glu Lys Lys Arg Ala Thr Lys Glu Leu Leu Ser Thr Ile Thr 
    130                 135                 140                 


Asp Pro Ser Val Ile Val Met Ala Asp Trp Leu Lys Ile Arg Gly Thr 
145                 150                 155                 160 


Leu Lys Ser Trp Thr Lys Leu Trp Cys Val Leu Lys Pro Gly Val Leu 
                165                 170                 175     


Leu Ile Tyr Lys Thr Gln Lys Asn Gly Gln Trp Val Gly Thr Val Leu 
            180                 185                 190         


Leu Asn Ala Cys Glu Ile Ile Glu Arg Pro Ser Lys Lys Asp Gly Phe 
        195                 200                 205             


Cys Phe Lys Leu Phe His Pro Leu Glu Gln Ser Ile Trp Ala Val Lys 
    210                 215                 220                 


Gly Pro Lys Gly Glu Ala Val Gly Ser Ile Thr Gln Pro Leu Pro Ser 
225                 230                 235                 240 


Ser Tyr Leu Ile Ile Arg Ala Thr Ser Glu Ser Asp Gly Arg Cys Trp 
                245                 250                 255     


Met Asp Ala Leu Glu Leu Ala Leu Lys Cys Ser Ser Leu Leu Lys Arg 
            260                 265                 270         


Thr Met Ile Arg Glu Gly Lys Glu His Asp Leu Ser Val Ser Ser Asp 
        275                 280                 285             


Ser Thr His Val Thr Phe Tyr Gly Leu Leu Arg Ala Asn Asn Leu His 
    290                 295                 300                 


Ser Gly Asp Asn Phe Gln Leu Asn Asp Ser Glu Ile Glu Arg Gln His 
305                 310                 315                 320 


Phe Lys Asp Gln Asp Met Tyr Ser Asp Lys Ser Asp Lys Glu Asn Asp 
                325                 330                 335     


Gln Glu His Asp Glu Ser Asp Asn Glu Val Met Gly Lys Ser Glu Glu 
            340                 345                 350         


Ser Asp Thr Asp Thr Ser Glu Arg Gln Asp Asp Ser Tyr Ile Glu Pro 
        355                 360                 365             


Glu Pro Val Glu Pro Leu Lys Glu Thr Thr Tyr Thr Glu Gln Ser His 
    370                 375                 380                 


Glu Glu Leu Gly Glu Ala Gly Glu Ala Ser Gln Thr Glu Thr Val Ser 
385                 390                 395                 400 


Glu Glu Asn Lys Ser Leu Ile Trp Thr Leu Leu Lys Gln Val Arg Pro 
                405                 410                 415     


Gly Met Asp Leu Ser Lys Val Val Leu Pro Thr Phe Ile Leu Glu Pro 
            420                 425                 430         


Arg Ser Phe Leu Asp Lys Leu Ser Asp Tyr Tyr Tyr His Ala Asp Phe 
        435                 440                 445             


Leu Ser Glu Ala Ala Leu Glu Glu Asn Pro Tyr Phe Arg Leu Lys Lys 
    450                 455                 460                 


Val Val Lys Trp Tyr Leu Ser Gly Phe Tyr Lys Lys Pro Lys Gly Leu 
465                 470                 475                 480 


Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Thr Phe Arg Cys Leu Trp 
                485                 490                 495     


Ile His Pro Arg Thr Asn Ser Lys Thr Phe Tyr Ile Ala Glu Gln Val 
            500                 505                 510         


Ser His His Pro Pro Ile Ser Ala Phe Tyr Val Ser Asn Arg Lys Asp 
        515                 520                 525             


Gly Phe Cys Leu Ser Gly Ser Ile Leu Ala Lys Ser Lys Phe Tyr Gly 
    530                 535                 540                 


Asn Ser Leu Ser Ala Ile Leu Glu Gly Glu Ala Arg Leu Thr Phe Leu 
545                 550                 555                 560 


Asn Arg Gly Glu Asp Tyr Val Met Thr Met Pro Tyr Ala His Cys Lys 
                565                 570                 575     


Gly Ile Leu Tyr Gly Thr Met Thr Leu Glu Leu Gly Gly Thr Val Asn 
            580                 585                 590         


Ile Thr Cys Gln Lys Thr Gly Tyr Ser Ala Ile Leu Glu Phe Lys Leu 
        595                 600                 605             


Lys Pro Phe Leu Gly Ser Ser Asp Cys Val Asn Gln Ile Ser Gly Lys 
    610                 615                 620                 


Leu Lys Leu Gly Lys Glu Val Leu Ala Thr Leu Glu Gly His Trp Asp 
625                 630                 635                 640 


Ser Glu Val Phe Ile Thr Asp Lys Lys Thr Asp Asn Ser Glu Val Phe 
                645                 650                 655     


Trp Asn Pro Thr Pro Asp Ile Lys Gln Trp Arg Leu Ile Arg His Thr 
            660                 665                 670         


Val Lys Phe Glu Glu Gln Gly Asp Phe Glu Ser Glu Lys Leu Trp Gln 
        675                 680                 685             


Arg Val Thr Arg Ala Ile Asn Ala Lys Asp Gln Thr Glu Ala Thr Gln 
    690                 695                 700                 


Glu Lys Tyr Val Leu Glu Glu Ala Gln Arg Gln Ala Ala Arg Asp Arg 
705                 710                 715                 720 


Lys Thr Lys Asn Glu Glu Trp Ser Cys Lys Leu Phe Glu Leu Asp Pro 
                725                 730                 735     


Leu Thr Gly Glu Trp His Tyr Lys Phe Ala Asp Thr Arg Pro Trp Asp 
            740                 745                 750         


Pro Leu Asn Asp Met Ile Gln Phe Glu Lys Asp Gly Val Ile Gln Thr 
        755                 760                 765             


Lys Val Lys His Arg Thr Pro Met Val Ser Val Pro Lys Met Lys His 
    770                 775                 780                 


Lys Pro Thr Arg Gln Gln Lys Lys Val Ala Lys Gly Tyr Ser Ser Pro 
785                 790                 795                 800 


Glu Pro Asp Ile Gln Asp Ser Ser Gly Ser Glu Ala Gln Ser Val Lys 
                805                 810                 815     


Pro Ser Thr Arg Arg Lys Lys Gly Ile Glu Leu Gly Asp Ile Gln Ser 
            820                 825                 830         


Ser Ile Glu Ser Ile Lys Gln Thr Gln Glu Glu Ile Lys Arg Asn Ile 
        835                 840                 845             


Met Ala Leu Arg Asn His Leu Val Ser Ser Thr Pro Ala Thr Asp Tyr 
    850                 855                 860                 


Phe Leu Gln Gln Lys Asp Tyr Phe Ile Ile Phe Leu Leu Ile Leu Leu 
865                 870                 875                 880 


Gln Val Ile Ile Asn Phe Met Phe Lys 
                885                 


<210>  2994
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  2994
tagaagcatt ttctttggca gcaagaagat aattttatag aagccatgcc tgttcttggg     60

gttgcctcaa aactgaggca gccagctgtt gggtcaaagc ctgtgcatac tgctcttccg    120

ataccaaatc ttggcactac tgggtcacag cactgttctt caagaccttt ggaacttgct    180

gaaacagaga gctccatgct ttcttgtcag cttgcgttaa aatcaacctg tgaatttgga    240

gagaagaaac ccctccaagg aaaagccaag gagaaagaag acagcaagat ttacactgac    300

tgggccaacc actacctagc aaaatcaggc cacaagcggc tgatcaagga cttgcaacaa    360

gacattgcag atggagtact cctagcagaa atcatccaga ttattgcaaa tgaaaaagtt    420

gaagatatca atggatgtcc tagaagtcag tctcagatga ttgaaaatgt tgatgtctgc    480

cttagttttc tagcagccag aggggtaaat gttcaaggtc tatctgctga agaaataaga    540

aatggaaact taaaagccat tctagggctg tttttcagtt tatctcgcta caagcagcaa    600

caacaccatc aacaacagta ctatcagtcc ttggtggaac ttcagcagcg agttactcac    660

gcttcccctc catcggaagc cagccaggcc aaaacccagc aagatatgca gtccagtctg    720

gcagccagat atgcaactca gtctaatcac agtggaattg caaccagtca aaaaaagcct    780

actaggcttc cagggccctc tagggtgcct gctgcaggaa gcagcagcaa ggtccaggga    840

gcctctaatt taaataggag aagtcagagc tttaacagca ttgacaaaaa caagcctcca    900

aattatgcaa atggaaacga aaaagattcc tccaaaggac ctcaatcgtc ttcaggtgta    960

aatggtaacg tgcagcctcc cagtactgct gggcagcctc ctgcctctgc catcccttct   1020

ccaagtgcca gcaagccctg gcgcagcaag tccatgaatg tcaaacacag tgccacctcc   1080

accatgttga ctgtaaagca gtcaagtaca gccacctccc ccacaccatc ttcagacaga   1140

ctgaagccac ctgtctcaga aggggtcaaa actgctccct caggacagaa atccatgctt   1200

gagaaattca agctagtcaa tgcccggact gctttacgcc ccccgcagcc tcccagttca   1260

ggacctagtg atggtgggaa ggatgatgat gccttttctg aatctggtga aatggaaggt   1320

tttaacagtg gtctgaatag tggtggctca acaaatagca gtcccaaagt gtcacctaag   1380

ttggcccctc caaaagctgg aagcaaaaat ctcagcaata aaaagtcttt gctacagcca   1440

aaggaaaaag aagaaaagaa cagggacaaa aataaagttt gcactgaaaa accagtcaaa   1500

gaagagaagg atcaggtgac agagatggct ccaaaaaaga cctccaaaat tgcaagcttg   1560

atccctaagg gcagcaagac aacagcagct aagaaggaaa gcttaattcc gtcttccagt   1620

ggtattccaa aaccaggctc taaagttcca acagtaaagc aaaccatttc acctggcagc   1680

acagcaagca aagagtctga gaaattcagg actaccaagg ggagcccttc ccagtcctta   1740

tctaagccta taaccatgga gaaagcaagt gcttctagtt gtcctgcccc tttggaagga   1800

agggaagctg gccaagcttc tccttctggt tcctgtacca tgacagtggc acaaagcagt   1860

gggcagagca caggaaatgg tgctgtccaa ctccctcaac agcagcaaca tagccacccg   1920

aataccgcga cagtggcacc attcatttac agggcacatt cagaaaatga aggtaccgct   1980

ttaccatcgg ctgactcctg taccagtcct acaaagatgg acttatcata tagtaagact   2040

gctaagcagt gcctggagga gatatctggt gaagaccctg aaacaagaag aatgagaaca   2100

gttaaaaaca tagcagactt gaggcagaat ttagaagaga ctatgtccag tcttcgtggg   2160

actcagataa gccacagcac cctggagaca acatttgaca gcactgtgac aacagaagtt   2220

aatggaagga ccatacccaa cttgacaagt cgacccaccc ccatgacctg gaggttgggc   2280

caggcatgtc cgcgacttca ggcgggagat gctccctccc tgggtgctgg ctatcctcgc   2340

agtggtacca gtcgattcat ccacacagac ccctcgaggt tcatgtatac cacgcctctc   2400

cgtcgagctg ctgtctctag gctgggaaac atgtcacaga ttgacatgag tgagaaagca   2460

agcagtgacc tggacatgtc ttctgaggtc gatgtgggtg gatatatgag tgatggtgat   2520

atccttggga aaagtctcag gactgatgac atcaacagtg ggtacatgac agatggagga   2580

cttaacctat atactagaag tctgaaccga ataccagaca cagcaacttc ccgggacatc   2640

atccagagag gggttcacga tgtgacagtg gatgcagaca gctgggatga cagcagttca   2700

gtgagcagtg gtctcagtga cacccttgat aacatcagca ctgatgacct gaacaccaca   2760

tcctctgtca gctcttactc caacatcacc gtcccctcta ggaagaatac tcagctgagg   2820

acagattcag agaaacgctc caccacagac gagacctggg atagtcctga ggaactgaaa   2880

aaaccagaag aagattttga cagccatggg gatgctggtg gcaagtggaa gactgtgtcc   2940

tctggacttc ctgaagaccc cgagaaggca gggcagaaag cttccctgtc tgtttcacag   3000

acaggttcct ggagaagagg catgtctgcc caaggagggg cgccatctag gcagaaagct   3060

ggaacaagtg cactcaaaac acccgggaaa accgatgatg ccaaagcttc tgagaaagga   3120

aaagctcccc taaaaggatc atctctacaa agatctcctt cagatgcagg aaaaagcagt   3180

ggagatgaag ggaaaaagcc cccctcaggc attggaagat cgactgccac cagctccttt   3240

ggctttaaga aaccaagtgg agtagggtca tctgccatga tcaccagcag tggagcaacc   3300

ataacaagtg gctctgcaac actgggtaaa attccaaaat ctgctgccat tggcgggaag   3360

tcaaatgcag ggagaaaaac cagtttggac ggttcacaga atcaggatga tgttgtgctg   3420

catgttagct caaagactac cctacaatat cgcagcttgc cccgcccttc aaaatccagc   3480

accagtggca ttcctggccg aggaggccac agatccagta ccagcagtat tgattccaac   3540

gtcagcagca agtctgctgg ggccaccacc tcgaaactga gagaaccaac taaaattggg   3600

tcagggcgct cgagtcctgt caccgtcaac caaacagaca aggaaaagga aaaagtagca   3660

gtctcagatt cagaaagtgt ttctttgtca ggttccccca aatccagccc cacctctgcc   3720

agcgcctgtg gtgcacaagg tctcaggcag ccaggatcca agtatccaga tattgcctca   3780

cccacatttc gaaggttgtt tggtgccaag gcaggtggca aatctgcctc tgcacctaat   3840

actgagggtg tgaaatcttc ctcagtaatg cccagcccta gtaccacatt agcgcggcaa   3900

ggcagtctgg agtcaccgtc gtccggtacg ggcagcatgg gcagtgctgg tgggctaagc   3960

ggcagcagca gccctctctt caataaaccc tcagacttaa ctacagatgt tataagctta   4020

agtcactcgt tggcctccag cccagcatcg gttcactctt tcacatcagg tggtctcgtg   4080

tgggctgcca atatgagcag ttcctctgca ggcagcaagg atactccgag ctaccagtcc   4140

atgactagcc tccacacgag ctctgagtcc attgacctcc ccctcagcca tcatggctcc   4200

ttgtctggac tgaccacagg cactcacgag gtccagagcc tgctcatgag aacgggtagt   4260

gtgagatcta ctctctcaga aagcatgcag cttgacagaa atacactacc caaaaaggga   4320

ctaagatata ccccatcatc tcggcaggcc aaccaagaag agggcaaaga gtggttgcgt   4380

tctcattcta ctggagggct tcaggacact ggcaaccagt cacctctggt ttccccttct   4440

gccatgtcat cttctgcagc tggaaaatac cacttttcta acttggtgag cccaacaaat   4500

ttgtctcagt ttaaccttcc cgggcccagc atgatgcgct caaacagcat cccagcccaa   4560

gactcttcct tcgatctcta tgatgactcc cagctttgtg ggagtgccac ttctctggag   4620

gaaagacctc gtgccatcag tcattcgggc tcattcagag acagcatgga agaagttcat   4680

ggctcttcat tatcactggt gtccagcact tcttctcttt actctacagc tgaagaaaag   4740

gctcattcag agcaaatcca taaactgcgg agagagctgg ttgcatcaca agaaaaagtt   4800

gctaccctca catctcagct ttcagcaaat gctcaccttg tagcagcttt tgaaaagagc   4860

ttagggaata tgactggccg attgcaaagt ctaactatga cagcggaaca aaaggaatct   4920

gaacttatag aactaagaga aaccattgaa atgctgaagg ctcagaattc tgctgcccag   4980

gcggctattc agggagcact gaatggtcca gaccatcctc ccaaagatct tcgcatcaga   5040

agacagcatt cctctgaaag tgtttctagt atcaacagtg ccacaagcca ttccagtatt   5100

ggcagtggta atgatgccga ctccaagaag aagaaaaaga aaaactgggt gaactctaga   5160

ggaagtgagc tgagaagttc tttcaaacaa gcctttggga agaaaaagtc caccaagcct   5220

ccttcatcac attctgacat tgaagagctt actgattcat cccttccggc atcccccaag   5280

ttaccccata atgctggtga ctgtggctca gcatccatga agccctcaca atctgcttca   5340

gcgatctgtg aatgcacaga agctgaggca gagataattc tgcagctgaa gagcgagctc   5400

agagaaaagg aattaaaatt aacggatatt cggctggagg ccctcagctc tgctcatcat   5460

cttgatcaga tccgggaagc catgaaccgg atgcagaatg aaattgaaat actgaaagct   5520

gaaaatgacc ggttgaaggc agaaactggt aacacagcta agcctactcg gccaccgtca   5580

gaatcctcaa gcagcacctc ctcttcatct tccaggcagt cattaggact ttctctaaac   5640

aatttgaaca tcacagaggc tgttagctca gatattttgc tagatgatgc tggtgatgca   5700

actggacata aagatggccg cagtgtgaaa attatagtct ccataagcaa gggctatggt   5760

cgagcaaagg accaaaaatc tcaggcatat ttgataggat ccattggtgt tagtggaaaa   5820

accaagtggg atgtcttaga tggtgtaata agacgtctct ttaaggaata tgtattccga   5880

attgatacat ccactagcct tggtctgagc tctgactgca ttgctagcta ctgtatagga   5940

gacttaatta gatcccataa cctagaagtg cctgaattgc tgccttgtgg ataccttgtt   6000

ggagataata acatcatcac tgtgaacctc aaaggggtag aagaaaatag tttggacagt   6060

tttgtttttg atacgctgat tcctaaacca attacccaaa ggtactttaa cttgttgatg   6120

gagcatcaca gaattatact ctcaggaccg agtggtactg gaaagaccta tttggcaaac   6180

aaacttgctg aatatgtaat aaccaaatct ggaaggaaaa aaacagagga tgcaattgcc   6240

acttttaatg tggaccacaa gtcaagtaag gaattgcaac aatatctagc taacctggct   6300

gaacagtgca gtgctgataa taatggagtg gagctcccag ttgtaataat tcttgataat   6360

cttcatcatg tgggctctct gagtgatatc ttcaatggtt ttctcaattg taaatacaac   6420

aaatgtccat atattattgg aacaatgaat cagggagttt cttcatcacc aaatctagag   6480

ctgcatcaca atttcaggtg ggtattatgt gcaaatcata cagaaccagt gaaaggcttt   6540

ttaggcagat atcttcgaag aaaactcata gagatagaaa ttgaaaggaa cattcgcaat   6600

aatgacctag tcaaaattat agattggatt ccgaagacgt ggcatcatct caacagtttt   6660

ttggaaacac acagttcttc tgacgttacc attggtcccc gactattcct tccttgcccc   6720

atggatgtag aaggttctag agtatggttc atggatctct ggaactattc tttagtacct   6780

tatattctgg aggcagtgag agagggtctt cagatgtatg ggaaacgcac accatgggaa   6840

gatccttcaa agtgggtgct tgacacatat ccatggagct cagcaactct gcctcaggag   6900

agcccagcct tacttcagct gcgaccagaa gatgttgggt atgaaagctg cacatccact   6960

aaggaagcca caacctcaaa gcacattccg caaactgaca cagaaggaga tcccctgatg   7020

aatatgctaa tgaaactcca agaagcagcc aattactcga gcacacaaag ctgcgacagc   7080

gaaagcacca gccaccatga agacattttg gattcatctc ttgaatctac cctctagagg   7140

gtgaaaaaag ttaagggaaa agactttgct tttaaaaaaa tgtttcaaaa gaaaggtatt   7200

ttcactaaac cactgccagt ataaaagcac cctgtcaagg gccctgaccc agagttgtgg   7260

tctccaagga ggcagcagaa ctaagtctga accgccaaga tgctaaattg caatggaagc   7320

ttaactttag tttatttcta agcatttttt atatctgtgg agtaatagaa agctccatta   7380

ctcaactgga aaggacccta atgacagggc aactgaacag attgcacatg ggatagccaa   7440

actggacttt ctttgtttcc tctttaaaag tttacaatgc agaccatttt ttgtcccttc   7500

cttttgtttc ctctgagggg ctgttcgccc caggcagggt ccatctttct gatctgtcca   7560

acctcctttg tgccacacgg tgctggtcac agggcttcag tagtgtttgt gttgtgcgct   7620

caccccattc cagaacaaat ccaagaggcc agtcctccat aagcacaaat ggaattgtgc   7680

aaccaccaga aaaacactac tgtggcaaac tggagaagtg ccaatttaat tctaactgcc   7740

acgttctcat gatgtgctcc accaactttt tagtatatga gtcactggtt ttataaggtt   7800

gtttttacca cagtggtctt tttaaaccac ctgcccactc ccttaacaag agttttatac   7860

caattattag tcaacactga taaaaggctt ttttagggct ttatttgttt gagccttttc   7920

agtgaaagaa ggaacatttc ctatggtgct gtctcactgc cttaaaacag atttctatga   7980

cagtttaaca gttggtttaa atcctaaacc attggtaatt tccactgtct tttcatttac   8040

aaccaagcaa caccagttaa catagtagcc tcatctctat atatctttct cttttttttt   8100

tttttgaaga aatggatagg agaaagatca gtatttttag ccttgtgaat agatcgcttt   8160

gcctatcctc caaaatatta aaataaccca ga                                 8192


<210>  2995
<211>  2363
<212>  PRT
<213>  Homosapiens

<400>  2995

Met Pro Val Leu Gly Val Ala Ser Lys Leu Arg Gln Pro Ala Val Gly 
1               5                   10                  15      


Ser Lys Pro Val His Thr Ala Leu Pro Ile Pro Asn Leu Gly Thr Thr 
            20                  25                  30          


Gly Ser Gln His Cys Ser Ser Arg Pro Leu Glu Leu Ala Glu Thr Glu 
        35                  40                  45              


Ser Ser Met Leu Ser Cys Gln Leu Ala Leu Lys Ser Thr Cys Glu Phe 
    50                  55                  60                  


Gly Glu Lys Lys Pro Leu Gln Gly Lys Ala Lys Glu Lys Glu Asp Ser 
65                  70                  75                  80  


Lys Ile Tyr Thr Asp Trp Ala Asn His Tyr Leu Ala Lys Ser Gly His 
                85                  90                  95      


Lys Arg Leu Ile Lys Asp Leu Gln Gln Asp Ile Ala Asp Gly Val Leu 
            100                 105                 110         


Leu Ala Glu Ile Ile Gln Ile Ile Ala Asn Glu Lys Val Glu Asp Ile 
        115                 120                 125             


Asn Gly Cys Pro Arg Ser Gln Ser Gln Met Ile Glu Asn Val Asp Val 
    130                 135                 140                 


Cys Leu Ser Phe Leu Ala Ala Arg Gly Val Asn Val Gln Gly Leu Ser 
145                 150                 155                 160 


Ala Glu Glu Ile Arg Asn Gly Asn Leu Lys Ala Ile Leu Gly Leu Phe 
                165                 170                 175     


Phe Ser Leu Ser Arg Tyr Lys Gln Gln Gln His His Gln Gln Gln Tyr 
            180                 185                 190         


Tyr Gln Ser Leu Val Glu Leu Gln Gln Arg Val Thr His Ala Ser Pro 
        195                 200                 205             


Pro Ser Glu Ala Ser Gln Ala Lys Thr Gln Gln Asp Met Gln Ser Ser 
    210                 215                 220                 


Leu Ala Ala Arg Tyr Ala Thr Gln Ser Asn His Ser Gly Ile Ala Thr 
225                 230                 235                 240 


Ser Gln Lys Lys Pro Thr Arg Leu Pro Gly Pro Ser Arg Val Pro Ala 
                245                 250                 255     


Ala Gly Ser Ser Ser Lys Val Gln Gly Ala Ser Asn Leu Asn Arg Arg 
            260                 265                 270         


Ser Gln Ser Phe Asn Ser Ile Asp Lys Asn Lys Pro Pro Asn Tyr Ala 
        275                 280                 285             


Asn Gly Asn Glu Lys Asp Ser Ser Lys Gly Pro Gln Ser Ser Ser Gly 
    290                 295                 300                 


Val Asn Gly Asn Val Gln Pro Pro Ser Thr Ala Gly Gln Pro Pro Ala 
305                 310                 315                 320 


Ser Ala Ile Pro Ser Pro Ser Ala Ser Lys Pro Trp Arg Ser Lys Ser 
                325                 330                 335     


Met Asn Val Lys His Ser Ala Thr Ser Thr Met Leu Thr Val Lys Gln 
            340                 345                 350         


Ser Ser Thr Ala Thr Ser Pro Thr Pro Ser Ser Asp Arg Leu Lys Pro 
        355                 360                 365             


Pro Val Ser Glu Gly Val Lys Thr Ala Pro Ser Gly Gln Lys Ser Met 
    370                 375                 380                 


Leu Glu Lys Phe Lys Leu Val Asn Ala Arg Thr Ala Leu Arg Pro Pro 
385                 390                 395                 400 


Gln Pro Pro Ser Ser Gly Pro Ser Asp Gly Gly Lys Asp Asp Asp Ala 
                405                 410                 415     


Phe Ser Glu Ser Gly Glu Met Glu Gly Phe Asn Ser Gly Leu Asn Ser 
            420                 425                 430         


Gly Gly Ser Thr Asn Ser Ser Pro Lys Val Ser Pro Lys Leu Ala Pro 
        435                 440                 445             


Pro Lys Ala Gly Ser Lys Asn Leu Ser Asn Lys Lys Ser Leu Leu Gln 
    450                 455                 460                 


Pro Lys Glu Lys Glu Glu Lys Asn Arg Asp Lys Asn Lys Val Cys Thr 
465                 470                 475                 480 


Glu Lys Pro Val Lys Glu Glu Lys Asp Gln Val Thr Glu Met Ala Pro 
                485                 490                 495     


Lys Lys Thr Ser Lys Ile Ala Ser Leu Ile Pro Lys Gly Ser Lys Thr 
            500                 505                 510         


Thr Ala Ala Lys Lys Glu Ser Leu Ile Pro Ser Ser Ser Gly Ile Pro 
        515                 520                 525             


Lys Pro Gly Ser Lys Val Pro Thr Val Lys Gln Thr Ile Ser Pro Gly 
    530                 535                 540                 


Ser Thr Ala Ser Lys Glu Ser Glu Lys Phe Arg Thr Thr Lys Gly Ser 
545                 550                 555                 560 


Pro Ser Gln Ser Leu Ser Lys Pro Ile Thr Met Glu Lys Ala Ser Ala 
                565                 570                 575     


Ser Ser Cys Pro Ala Pro Leu Glu Gly Arg Glu Ala Gly Gln Ala Ser 
            580                 585                 590         


Pro Ser Gly Ser Cys Thr Met Thr Val Ala Gln Ser Ser Gly Gln Ser 
        595                 600                 605             


Thr Gly Asn Gly Ala Val Gln Leu Pro Gln Gln Gln Gln His Ser His 
    610                 615                 620                 


Pro Asn Thr Ala Thr Val Ala Pro Phe Ile Tyr Arg Ala His Ser Glu 
625                 630                 635                 640 


Asn Glu Gly Thr Ala Leu Pro Ser Ala Asp Ser Cys Thr Ser Pro Thr 
                645                 650                 655     


Lys Met Asp Leu Ser Tyr Ser Lys Thr Ala Lys Gln Cys Leu Glu Glu 
            660                 665                 670         


Ile Ser Gly Glu Asp Pro Glu Thr Arg Arg Met Arg Thr Val Lys Asn 
        675                 680                 685             


Ile Ala Asp Leu Arg Gln Asn Leu Glu Glu Thr Met Ser Ser Leu Arg 
    690                 695                 700                 


Gly Thr Gln Ile Ser His Ser Thr Leu Glu Thr Thr Phe Asp Ser Thr 
705                 710                 715                 720 


Val Thr Thr Glu Val Asn Gly Arg Thr Ile Pro Asn Leu Thr Ser Arg 
                725                 730                 735     


Pro Thr Pro Met Thr Trp Arg Leu Gly Gln Ala Cys Pro Arg Leu Gln 
            740                 745                 750         


Ala Gly Asp Ala Pro Ser Leu Gly Ala Gly Tyr Pro Arg Ser Gly Thr 
        755                 760                 765             


Ser Arg Phe Ile His Thr Asp Pro Ser Arg Phe Met Tyr Thr Thr Pro 
    770                 775                 780                 


Leu Arg Arg Ala Ala Val Ser Arg Leu Gly Asn Met Ser Gln Ile Asp 
785                 790                 795                 800 


Met Ser Glu Lys Ala Ser Ser Asp Leu Asp Met Ser Ser Glu Val Asp 
                805                 810                 815     


Val Gly Gly Tyr Met Ser Asp Gly Asp Ile Leu Gly Lys Ser Leu Arg 
            820                 825                 830         


Thr Asp Asp Ile Asn Ser Gly Tyr Met Thr Asp Gly Gly Leu Asn Leu 
        835                 840                 845             


Tyr Thr Arg Ser Leu Asn Arg Ile Pro Asp Thr Ala Thr Ser Arg Asp 
    850                 855                 860                 


Ile Ile Gln Arg Gly Val His Asp Val Thr Val Asp Ala Asp Ser Trp 
865                 870                 875                 880 


Asp Asp Ser Ser Ser Val Ser Ser Gly Leu Ser Asp Thr Leu Asp Asn 
                885                 890                 895     


Ile Ser Thr Asp Asp Leu Asn Thr Thr Ser Ser Val Ser Ser Tyr Ser 
            900                 905                 910         


Asn Ile Thr Val Pro Ser Arg Lys Asn Thr Gln Leu Arg Thr Asp Ser 
        915                 920                 925             


Glu Lys Arg Ser Thr Thr Asp Glu Thr Trp Asp Ser Pro Glu Glu Leu 
    930                 935                 940                 


Lys Lys Pro Glu Glu Asp Phe Asp Ser His Gly Asp Ala Gly Gly Lys 
945                 950                 955                 960 


Trp Lys Thr Val Ser Ser Gly Leu Pro Glu Asp Pro Glu Lys Ala Gly 
                965                 970                 975     


Gln Lys Ala Ser Leu Ser Val Ser Gln Thr Gly Ser Trp Arg Arg Gly 
            980                 985                 990         


Met Ser Ala Gln Gly Gly Ala Pro  Ser Arg Gln Lys Ala  Gly Thr Ser 
        995                 1000                 1005             


Ala Leu  Lys Thr Pro Gly Lys  Thr Asp Asp Ala Lys  Ala Ser Glu 
    1010                 1015                 1020             


Lys Gly  Lys Ala Pro Leu Lys  Gly Ser Ser Leu Gln  Arg Ser Pro 
    1025                 1030                 1035             


Ser Asp  Ala Gly Lys Ser Ser  Gly Asp Glu Gly Lys  Lys Pro Pro 
    1040                 1045                 1050             


Ser Gly  Ile Gly Arg Ser Thr  Ala Thr Ser Ser Phe  Gly Phe Lys 
    1055                 1060                 1065             


Lys Pro  Ser Gly Val Gly Ser  Ser Ala Met Ile Thr  Ser Ser Gly 
    1070                 1075                 1080             


Ala Thr  Ile Thr Ser Gly Ser  Ala Thr Leu Gly Lys  Ile Pro Lys 
    1085                 1090                 1095             


Ser Ala  Ala Ile Gly Gly Lys  Ser Asn Ala Gly Arg  Lys Thr Ser 
    1100                 1105                 1110             


Leu Asp  Gly Ser Gln Asn Gln  Asp Asp Val Val Leu  His Val Ser 
    1115                 1120                 1125             


Ser Lys  Thr Thr Leu Gln Tyr  Arg Ser Leu Pro Arg  Pro Ser Lys 
    1130                 1135                 1140             


Ser Ser  Thr Ser Gly Ile Pro  Gly Arg Gly Gly His  Arg Ser Ser 
    1145                 1150                 1155             


Thr Ser  Ser Ile Asp Ser Asn  Val Ser Ser Lys Ser  Ala Gly Ala 
    1160                 1165                 1170             


Thr Thr  Ser Lys Leu Arg Glu  Pro Thr Lys Ile Gly  Ser Gly Arg 
    1175                 1180                 1185             


Ser Ser  Pro Val Thr Val Asn  Gln Thr Asp Lys Glu  Lys Glu Lys 
    1190                 1195                 1200             


Val Ala  Val Ser Asp Ser Glu  Ser Val Ser Leu Ser  Gly Ser Pro 
    1205                 1210                 1215             


Lys Ser  Ser Pro Thr Ser Ala  Ser Ala Cys Gly Ala  Gln Gly Leu 
    1220                 1225                 1230             


Arg Gln  Pro Gly Ser Lys Tyr  Pro Asp Ile Ala Ser  Pro Thr Phe 
    1235                 1240                 1245             


Arg Arg  Leu Phe Gly Ala Lys  Ala Gly Gly Lys Ser  Ala Ser Ala 
    1250                 1255                 1260             


Pro Asn  Thr Glu Gly Val Lys  Ser Ser Ser Val Met  Pro Ser Pro 
    1265                 1270                 1275             


Ser Thr  Thr Leu Ala Arg Gln  Gly Ser Leu Glu Ser  Pro Ser Ser 
    1280                 1285                 1290             


Gly Thr  Gly Ser Met Gly Ser  Ala Gly Gly Leu Ser  Gly Ser Ser 
    1295                 1300                 1305             


Ser Pro  Leu Phe Asn Lys Pro  Ser Asp Leu Thr Thr  Asp Val Ile 
    1310                 1315                 1320             


Ser Leu  Ser His Ser Leu Ala  Ser Ser Pro Ala Ser  Val His Ser 
    1325                 1330                 1335             


Phe Thr  Ser Gly Gly Leu Val  Trp Ala Ala Asn Met  Ser Ser Ser 
    1340                 1345                 1350             


Ser Ala  Gly Ser Lys Asp Thr  Pro Ser Tyr Gln Ser  Met Thr Ser 
    1355                 1360                 1365             


Leu His  Thr Ser Ser Glu Ser  Ile Asp Leu Pro Leu  Ser His His 
    1370                 1375                 1380             


Gly Ser  Leu Ser Gly Leu Thr  Thr Gly Thr His Glu  Val Gln Ser 
    1385                 1390                 1395             


Leu Leu  Met Arg Thr Gly Ser  Val Arg Ser Thr Leu  Ser Glu Ser 
    1400                 1405                 1410             


Met Gln  Leu Asp Arg Asn Thr  Leu Pro Lys Lys Gly  Leu Arg Tyr 
    1415                 1420                 1425             


Thr Pro  Ser Ser Arg Gln Ala  Asn Gln Glu Glu Gly  Lys Glu Trp 
    1430                 1435                 1440             


Leu Arg  Ser His Ser Thr Gly  Gly Leu Gln Asp Thr  Gly Asn Gln 
    1445                 1450                 1455             


Ser Pro  Leu Val Ser Pro Ser  Ala Met Ser Ser Ser  Ala Ala Gly 
    1460                 1465                 1470             


Lys Tyr  His Phe Ser Asn Leu  Val Ser Pro Thr Asn  Leu Ser Gln 
    1475                 1480                 1485             


Phe Asn  Leu Pro Gly Pro Ser  Met Met Arg Ser Asn  Ser Ile Pro 
    1490                 1495                 1500             


Ala Gln  Asp Ser Ser Phe Asp  Leu Tyr Asp Asp Ser  Gln Leu Cys 
    1505                 1510                 1515             


Gly Ser  Ala Thr Ser Leu Glu  Glu Arg Pro Arg Ala  Ile Ser His 
    1520                 1525                 1530             


Ser Gly  Ser Phe Arg Asp Ser  Met Glu Glu Val His  Gly Ser Ser 
    1535                 1540                 1545             


Leu Ser  Leu Val Ser Ser Thr  Ser Ser Leu Tyr Ser  Thr Ala Glu 
    1550                 1555                 1560             


Glu Lys  Ala His Ser Glu Gln  Ile His Lys Leu Arg  Arg Glu Leu 
    1565                 1570                 1575             


Val Ala  Ser Gln Glu Lys Val  Ala Thr Leu Thr Ser  Gln Leu Ser 
    1580                 1585                 1590             


Ala Asn  Ala His Leu Val Ala  Ala Phe Glu Lys Ser  Leu Gly Asn 
    1595                 1600                 1605             


Met Thr  Gly Arg Leu Gln Ser  Leu Thr Met Thr Ala  Glu Gln Lys 
    1610                 1615                 1620             


Glu Ser  Glu Leu Ile Glu Leu  Arg Glu Thr Ile Glu  Met Leu Lys 
    1625                 1630                 1635             


Ala Gln  Asn Ser Ala Ala Gln  Ala Ala Ile Gln Gly  Ala Leu Asn 
    1640                 1645                 1650             


Gly Pro  Asp His Pro Pro Lys  Asp Leu Arg Ile Arg  Arg Gln His 
    1655                 1660                 1665             


Ser Ser  Glu Ser Val Ser Ser  Ile Asn Ser Ala Thr  Ser His Ser 
    1670                 1675                 1680             


Ser Ile  Gly Ser Gly Asn Asp  Ala Asp Ser Lys Lys  Lys Lys Lys 
    1685                 1690                 1695             


Lys Asn  Trp Val Asn Ser Arg  Gly Ser Glu Leu Arg  Ser Ser Phe 
    1700                 1705                 1710             


Lys Gln  Ala Phe Gly Lys Lys  Lys Ser Thr Lys Pro  Pro Ser Ser 
    1715                 1720                 1725             


His Ser  Asp Ile Glu Glu Leu  Thr Asp Ser Ser Leu  Pro Ala Ser 
    1730                 1735                 1740             


Pro Lys  Leu Pro His Asn Ala  Gly Asp Cys Gly Ser  Ala Ser Met 
    1745                 1750                 1755             


Lys Pro  Ser Gln Ser Ala Ser  Ala Ile Cys Glu Cys  Thr Glu Ala 
    1760                 1765                 1770             


Glu Ala  Glu Ile Ile Leu Gln  Leu Lys Ser Glu Leu  Arg Glu Lys 
    1775                 1780                 1785             


Glu Leu  Lys Leu Thr Asp Ile  Arg Leu Glu Ala Leu  Ser Ser Ala 
    1790                 1795                 1800             


His His  Leu Asp Gln Ile Arg  Glu Ala Met Asn Arg  Met Gln Asn 
    1805                 1810                 1815             


Glu Ile  Glu Ile Leu Lys Ala  Glu Asn Asp Arg Leu  Lys Ala Glu 
    1820                 1825                 1830             


Thr Gly  Asn Thr Ala Lys Pro  Thr Arg Pro Pro Ser  Glu Ser Ser 
    1835                 1840                 1845             


Ser Ser  Thr Ser Ser Ser Ser  Ser Arg Gln Ser Leu  Gly Leu Ser 
    1850                 1855                 1860             


Leu Asn  Asn Leu Asn Ile Thr  Glu Ala Val Ser Ser  Asp Ile Leu 
    1865                 1870                 1875             


Leu Asp  Asp Ala Gly Asp Ala  Thr Gly His Lys Asp  Gly Arg Ser 
    1880                 1885                 1890             


Val Lys  Ile Ile Val Ser Ile  Ser Lys Gly Tyr Gly  Arg Ala Lys 
    1895                 1900                 1905             


Asp Gln  Lys Ser Gln Ala Tyr  Leu Ile Gly Ser Ile  Gly Val Ser 
    1910                 1915                 1920             


Gly Lys  Thr Lys Trp Asp Val  Leu Asp Gly Val Ile  Arg Arg Leu 
    1925                 1930                 1935             


Phe Lys  Glu Tyr Val Phe Arg  Ile Asp Thr Ser Thr  Ser Leu Gly 
    1940                 1945                 1950             


Leu Ser  Ser Asp Cys Ile Ala  Ser Tyr Cys Ile Gly  Asp Leu Ile 
    1955                 1960                 1965             


Arg Ser  His Asn Leu Glu Val  Pro Glu Leu Leu Pro  Cys Gly Tyr 
    1970                 1975                 1980             


Leu Val  Gly Asp Asn Asn Ile  Ile Thr Val Asn Leu  Lys Gly Val 
    1985                 1990                 1995             


Glu Glu  Asn Ser Leu Asp Ser  Phe Val Phe Asp Thr  Leu Ile Pro 
    2000                 2005                 2010             


Lys Pro  Ile Thr Gln Arg Tyr  Phe Asn Leu Leu Met  Glu His His 
    2015                 2020                 2025             


Arg Ile  Ile Leu Ser Gly Pro  Ser Gly Thr Gly Lys  Thr Tyr Leu 
    2030                 2035                 2040             


Ala Asn  Lys Leu Ala Glu Tyr  Val Ile Thr Lys Ser  Gly Arg Lys 
    2045                 2050                 2055             


Lys Thr  Glu Asp Ala Ile Ala  Thr Phe Asn Val Asp  His Lys Ser 
    2060                 2065                 2070             


Ser Lys  Glu Leu Gln Gln Tyr  Leu Ala Asn Leu Ala  Glu Gln Cys 
    2075                 2080                 2085             


Ser Ala  Asp Asn Asn Gly Val  Glu Leu Pro Val Val  Ile Ile Leu 
    2090                 2095                 2100             


Asp Asn  Leu His His Val Gly  Ser Leu Ser Asp Ile  Phe Asn Gly 
    2105                 2110                 2115             


Phe Leu  Asn Cys Lys Tyr Asn  Lys Cys Pro Tyr Ile  Ile Gly Thr 
    2120                 2125                 2130             


Met Asn  Gln Gly Val Ser Ser  Ser Pro Asn Leu Glu  Leu His His 
    2135                 2140                 2145             


Asn Phe  Arg Trp Val Leu Cys  Ala Asn His Thr Glu  Pro Val Lys 
    2150                 2155                 2160             


Gly Phe  Leu Gly Arg Tyr Leu  Arg Arg Lys Leu Ile  Glu Ile Glu 
    2165                 2170                 2175             


Ile Glu  Arg Asn Ile Arg Asn  Asn Asp Leu Val Lys  Ile Ile Asp 
    2180                 2185                 2190             


Trp Ile  Pro Lys Thr Trp His  His Leu Asn Ser Phe  Leu Glu Thr 
    2195                 2200                 2205             


His Ser  Ser Ser Asp Val Thr  Ile Gly Pro Arg Leu  Phe Leu Pro 
    2210                 2215                 2220             


Cys Pro  Met Asp Val Glu Gly  Ser Arg Val Trp Phe  Met Asp Leu 
    2225                 2230                 2235             


Trp Asn  Tyr Ser Leu Val Pro  Tyr Ile Leu Glu Ala  Val Arg Glu 
    2240                 2245                 2250             


Gly Leu  Gln Met Tyr Gly Lys  Arg Thr Pro Trp Glu  Asp Pro Ser 
    2255                 2260                 2265             


Lys Trp  Val Leu Asp Thr Tyr  Pro Trp Ser Ser Ala  Thr Leu Pro 
    2270                 2275                 2280             


Gln Glu  Ser Pro Ala Leu Leu  Gln Leu Arg Pro Glu  Asp Val Gly 
    2285                 2290                 2295             


Tyr Glu  Ser Cys Thr Ser Thr  Lys Glu Ala Thr Thr  Ser Lys His 
    2300                 2305                 2310             


Ile Pro  Gln Thr Asp Thr Glu  Gly Asp Pro Leu Met  Asn Met Leu 
    2315                 2320                 2325             


Met Lys  Leu Gln Glu Ala Ala  Asn Tyr Ser Ser Thr  Gln Ser Cys 
    2330                 2335                 2340             


Asp Ser  Glu Ser Thr Ser His  His Glu Asp Ile Leu  Asp Ser Ser 
    2345                 2350                 2355             


Leu Glu  Ser Thr Leu 
    2360             


<210>  2996
<211>  4052
<212>  DNA
<213>  Homosapiens

<400>  2996
gaggcaagtg aggagagaag atgctgtagc gtcctcaccg gctgccagca gggaaatggt     60

ccaggagtgc tgggtgtgag cctcccttct cctcaagccg gagactgcgg ttgtcattga    120

tcaattgaag aagcaaggac ccgaaatcac agacattagc aatgatgtgt gaagtgatgc    180

ccacgattaa tgaggacacc ccaatgagcc aaagggggtc ccaaagcagt ggctcggact    240

cagactccca ttttgagcag ctgatggtga atatgctaga tgaaagggat cgtcttctag    300

acacccttcg ggagacccag gaaagcctct cacttgccca gcaaagactt caggatgtca    360

tctatgaccg agactcactc cagagacagc tcaattcagc cctgccacag gatatcgaat    420

ccctaacagg agggctggct ggttctaagg gggctgatcc accggaattt gctgcactga    480

caaaagaatt aaatgcctgc agggaacaac ttctagaaaa ggaagaagaa atctctgaac    540

ttaaagctga aagaaacaac acaagactat tactggagca tttggagtgc cttgtgtcac    600

gacatgaaag atcactaaga atgacggtgg taaaacggca agcccagtct ccctcaggag    660

tatccagtga agttgaagtt ctcaaggcac tgaaatcttt gtttgagcac cacaaggcct    720

tggatgaaaa ggtaagggag cgactgaggg tttctttaga aagagtctct gcactggaag    780

aagaactagc tgctgctaat caggagattg ttgccttgcg tgaacaaaat gttcatatac    840

aaagaaaaat ggcatcaagc gagggatcca cagagtcaga acatcttgaa gggatggaac    900

ctggacagaa agtccatgag aagcgtttgt ccaatggttc tatagactca accgatgaaa    960

ctagtcaaat agttgaacta caagaattgc ttgaaaagca aaactatgaa atggcccaga   1020

tgaaagaacg tttagcagcc ctttcttccc gagtgggaga ggtggaacag gaagcagaga   1080

cagcaagaaa ggatctcatt aaaacagaag aaatgaacac caagtatcaa agggacatta   1140

gggaggccat ggcacaaaag gaagatatgg aagaaagaat tacaaccctt gaaaagcgtt   1200

acctcagtgc tcagagagaa tctacctcca tacatgacat gaatgataaa ctagaaaatg   1260

agttagcaaa taaagaagct atcctgcggc agatggaaga gaaaaacaga cagttacaag   1320

aacgtcttga gctagctgaa caaaagttgc agcagaccat gagaaaggct gaaaccttgc   1380

ctgaagtaga ggctgaactg gctcagagaa ttgcagccct aaccaaggct gaagagagac   1440

atggaaatat tgaagaacgt atgagacatt tagagggtca acttgaagag aagaatcaag   1500

aacttcaaag agctaggcaa agagagaaaa tgaatgagga gcataacaag agattatcgg   1560

atacggttga tagacttctg actgaatcca atgaacgcct acaactacac ttaaaggaaa   1620

gaatggctgc tctagaagaa aagaatgttt taattcaaga atcagaaact ttcagaaaga   1680

atcttgaaga atctttacat gataaggaaa gattagcaga agaaattgaa aagctgagat   1740

ctgaacttga ccaattgaaa atgagaactg gctctttaat tgaacccaca ataccaagaa   1800

ctcatctaga cacctcagct gagttgcggt actcagtggg atccctagtg gacagccagt   1860

ctgattacag aacaactaaa gtaataagaa gaccaaggag aggccgcatg ggtgtgcgaa   1920

gagatgagcc aaaggtgaaa tctcttgggg atcacgagtg gaatagaact caacagattg   1980

gagtactaag cagccaccct tttgaaagtg acactgaaat gtctgatatt gatgatgatg   2040

acagagaaac aatttttagc tcaatggatc ttctctctcc aagtggtcat tccgatgccc   2100

agacgctagc catgatgctt caggaacaat tggatgccat caacaaagaa atcaggctaa   2160

ttcaggaaga aaaagaatct acagagttgc gtgctgaaga aattgaaaat agagtggcta   2220

gtgtgagcct cgaaggcctg aatttggcaa gggtccaccc aggtacctcc attactgcct   2280

ctgttacagc ttcatcgctg gccagttcat ctccccccag tggacactca actccaaagc   2340

tcacccctcg aagccctgcc agggaaatgg atcggatggg agtcatgaca ctgccaagtg   2400

atctgaggaa acatcggaga aagattgcag ttgtggaaga agatggtcga gaggacaaag   2460

caacaattaa atgtgaaact tctcctcctc ctacccctag agccctcaga atgactcaca   2520

ctctcccttc ttcctaccac aatgatgctc gaagtagttt atctgtctct cttgagccag   2580

aaagcctcgg gcttggtagt gccaacagca gccaagactc tcttcacaaa gcccccaaga   2640

agaaaggaat caagtcttca ataggacgtt tgtttggtaa aaaagaaaaa gctcgacttg   2700

ggcagctccg aggctttatg gagactgaag ctgcagctca ggagtccctg gggttaggca   2760

aactcggaac tcaagctgag aaggatcgaa gactaaagaa aaagcatgaa cttcttgaag   2820

aagctcggag aaagggatta ccttttgccc agtgggatgg gccaactgtg gtcgcatggc   2880

tagagctttg gttgggaatg cctgcgtggt acgtggcagc ctgccgagcc aacgtgaaga   2940

gtggtgccat catgtctgct ttatctgaca ctgagatcca gagagaaatt ggaatcagca   3000

atccactgca tcgcttaaaa cttcgattag caatccagga gatggtttcc ctaacaagtc   3060

cttcagctcc tccaacatct cgaactcctt caggcaacgt ttgggtgact catgaagaaa   3120

tggaaaatct tgcagctcca gcaaaaacga aagaatctga ggaaggaagc tgggcccagt   3180

gtccggtttt tctacagacc ctggcttatg gagatatgaa tcatgagtgg attggaaatg   3240

aatggcttcc cagcttgggg ttacctcagt acagaagtta ctttatggaa tgcttggtag   3300

atgcaagaat gttagatcac ctaacaaaaa aagatctccg tgtccattta aaaatggtgg   3360

atagtttcca tcgaacaagt ttacaatatg gaattatgtg cttaaagagg ttgaattatg   3420

acagaaaaga actagaaaga agacgggaag caagccaaca tgaaataaaa gacgtgttgg   3480

tgtggagcaa tgaccgagtt attcgctgga tacaagcaat tggacttcga gaatatgcaa   3540

ataatatact tgagagcggt gtgcatggct cacttatagc cctggatgaa aactttgact   3600

acagcagctt agctttatta ttacagattc caacacagaa cacccaggca aggcagattc   3660

ttgaaagaga atacaataac ctcttggccc tgggaactga aaggcgactg gatgaaagtg   3720

atgacaagaa cttcagacgt ggatcaacct ggagaaggca gtttcctcct cgtgaagtac   3780

atggaatcag catgatgcct gggtcctcag aaacattacc agctggattt aggttaacca   3840

caacctctgg gcagtcaaga aaaatgacaa cagatgttgc ttcatcaaga ctgcagaggt   3900

tagacaactc cactgttcgc acatactcat gttgaccagc cactcaaagg aggcagcact   3960

gacctgctat ggcgtctttt cagtctactc tacctaaagt gcactaccat ctaagaagac   4020

gagcagtgaa aacctttgtg aaaactgaat tc                                 4052


<210>  2997
<211>  1257
<212>  PRT
<213>  Homosapiens

<400>  2997

Met Met Cys Glu Val Met Pro Thr Ile Asn Glu Asp Thr Pro Met Ser 
1               5                   10                  15      


Gln Arg Gly Ser Gln Ser Ser Gly Ser Asp Ser Asp Ser His Phe Glu 
            20                  25                  30          


Gln Leu Met Val Asn Met Leu Asp Glu Arg Asp Arg Leu Leu Asp Thr 
        35                  40                  45              


Leu Arg Glu Thr Gln Glu Ser Leu Ser Leu Ala Gln Gln Arg Leu Gln 
    50                  55                  60                  


Asp Val Ile Tyr Asp Arg Asp Ser Leu Gln Arg Gln Leu Asn Ser Ala 
65                  70                  75                  80  


Leu Pro Gln Asp Ile Glu Ser Leu Thr Gly Gly Leu Ala Gly Ser Lys 
                85                  90                  95      


Gly Ala Asp Pro Pro Glu Phe Ala Ala Leu Thr Lys Glu Leu Asn Ala 
            100                 105                 110         


Cys Arg Glu Gln Leu Leu Glu Lys Glu Glu Glu Ile Ser Glu Leu Lys 
        115                 120                 125             


Ala Glu Arg Asn Asn Thr Arg Leu Leu Leu Glu His Leu Glu Cys Leu 
    130                 135                 140                 


Val Ser Arg His Glu Arg Ser Leu Arg Met Thr Val Val Lys Arg Gln 
145                 150                 155                 160 


Ala Gln Ser Pro Ser Gly Val Ser Ser Glu Val Glu Val Leu Lys Ala 
                165                 170                 175     


Leu Lys Ser Leu Phe Glu His His Lys Ala Leu Asp Glu Lys Val Arg 
            180                 185                 190         


Glu Arg Leu Arg Val Ser Leu Glu Arg Val Ser Ala Leu Glu Glu Glu 
        195                 200                 205             


Leu Ala Ala Ala Asn Gln Glu Ile Val Ala Leu Arg Glu Gln Asn Val 
    210                 215                 220                 


His Ile Gln Arg Lys Met Ala Ser Ser Glu Gly Ser Thr Glu Ser Glu 
225                 230                 235                 240 


His Leu Glu Gly Met Glu Pro Gly Gln Lys Val His Glu Lys Arg Leu 
                245                 250                 255     


Ser Asn Gly Ser Ile Asp Ser Thr Asp Glu Thr Ser Gln Ile Val Glu 
            260                 265                 270         


Leu Gln Glu Leu Leu Glu Lys Gln Asn Tyr Glu Met Ala Gln Met Lys 
        275                 280                 285             


Glu Arg Leu Ala Ala Leu Ser Ser Arg Val Gly Glu Val Glu Gln Glu 
    290                 295                 300                 


Ala Glu Thr Ala Arg Lys Asp Leu Ile Lys Thr Glu Glu Met Asn Thr 
305                 310                 315                 320 


Lys Tyr Gln Arg Asp Ile Arg Glu Ala Met Ala Gln Lys Glu Asp Met 
                325                 330                 335     


Glu Glu Arg Ile Thr Thr Leu Glu Lys Arg Tyr Leu Ser Ala Gln Arg 
            340                 345                 350         


Glu Ser Thr Ser Ile His Asp Met Asn Asp Lys Leu Glu Asn Glu Leu 
        355                 360                 365             


Ala Asn Lys Glu Ala Ile Leu Arg Gln Met Glu Glu Lys Asn Arg Gln 
    370                 375                 380                 


Leu Gln Glu Arg Leu Glu Leu Ala Glu Gln Lys Leu Gln Gln Thr Met 
385                 390                 395                 400 


Arg Lys Ala Glu Thr Leu Pro Glu Val Glu Ala Glu Leu Ala Gln Arg 
                405                 410                 415     


Ile Ala Ala Leu Thr Lys Ala Glu Glu Arg His Gly Asn Ile Glu Glu 
            420                 425                 430         


Arg Met Arg His Leu Glu Gly Gln Leu Glu Glu Lys Asn Gln Glu Leu 
        435                 440                 445             


Gln Arg Ala Arg Gln Arg Glu Lys Met Asn Glu Glu His Asn Lys Arg 
    450                 455                 460                 


Leu Ser Asp Thr Val Asp Arg Leu Leu Thr Glu Ser Asn Glu Arg Leu 
465                 470                 475                 480 


Gln Leu His Leu Lys Glu Arg Met Ala Ala Leu Glu Glu Lys Asn Val 
                485                 490                 495     


Leu Ile Gln Glu Ser Glu Thr Phe Arg Lys Asn Leu Glu Glu Ser Leu 
            500                 505                 510         


His Asp Lys Glu Arg Leu Ala Glu Glu Ile Glu Lys Leu Arg Ser Glu 
        515                 520                 525             


Leu Asp Gln Leu Lys Met Arg Thr Gly Ser Leu Ile Glu Pro Thr Ile 
    530                 535                 540                 


Pro Arg Thr His Leu Asp Thr Ser Ala Glu Leu Arg Tyr Ser Val Gly 
545                 550                 555                 560 


Ser Leu Val Asp Ser Gln Ser Asp Tyr Arg Thr Thr Lys Val Ile Arg 
                565                 570                 575     


Arg Pro Arg Arg Gly Arg Met Gly Val Arg Arg Asp Glu Pro Lys Val 
            580                 585                 590         


Lys Ser Leu Gly Asp His Glu Trp Asn Arg Thr Gln Gln Ile Gly Val 
        595                 600                 605             


Leu Ser Ser His Pro Phe Glu Ser Asp Thr Glu Met Ser Asp Ile Asp 
    610                 615                 620                 


Asp Asp Asp Arg Glu Thr Ile Phe Ser Ser Met Asp Leu Leu Ser Pro 
625                 630                 635                 640 


Ser Gly His Ser Asp Ala Gln Thr Leu Ala Met Met Leu Gln Glu Gln 
                645                 650                 655     


Leu Asp Ala Ile Asn Lys Glu Ile Arg Leu Ile Gln Glu Glu Lys Glu 
            660                 665                 670         


Ser Thr Glu Leu Arg Ala Glu Glu Ile Glu Asn Arg Val Ala Ser Val 
        675                 680                 685             


Ser Leu Glu Gly Leu Asn Leu Ala Arg Val His Pro Gly Thr Ser Ile 
    690                 695                 700                 


Thr Ala Ser Val Thr Ala Ser Ser Leu Ala Ser Ser Ser Pro Pro Ser 
705                 710                 715                 720 


Gly His Ser Thr Pro Lys Leu Thr Pro Arg Ser Pro Ala Arg Glu Met 
                725                 730                 735     


Asp Arg Met Gly Val Met Thr Leu Pro Ser Asp Leu Arg Lys His Arg 
            740                 745                 750         


Arg Lys Ile Ala Val Val Glu Glu Asp Gly Arg Glu Asp Lys Ala Thr 
        755                 760                 765             


Ile Lys Cys Glu Thr Ser Pro Pro Pro Thr Pro Arg Ala Leu Arg Met 
    770                 775                 780                 


Thr His Thr Leu Pro Ser Ser Tyr His Asn Asp Ala Arg Ser Ser Leu 
785                 790                 795                 800 


Ser Val Ser Leu Glu Pro Glu Ser Leu Gly Leu Gly Ser Ala Asn Ser 
                805                 810                 815     


Ser Gln Asp Ser Leu His Lys Ala Pro Lys Lys Lys Gly Ile Lys Ser 
            820                 825                 830         


Ser Ile Gly Arg Leu Phe Gly Lys Lys Glu Lys Ala Arg Leu Gly Gln 
        835                 840                 845             


Leu Arg Gly Phe Met Glu Thr Glu Ala Ala Ala Gln Glu Ser Leu Gly 
    850                 855                 860                 


Leu Gly Lys Leu Gly Thr Gln Ala Glu Lys Asp Arg Arg Leu Lys Lys 
865                 870                 875                 880 


Lys His Glu Leu Leu Glu Glu Ala Arg Arg Lys Gly Leu Pro Phe Ala 
                885                 890                 895     


Gln Trp Asp Gly Pro Thr Val Val Ala Trp Leu Glu Leu Trp Leu Gly 
            900                 905                 910         


Met Pro Ala Trp Tyr Val Ala Ala Cys Arg Ala Asn Val Lys Ser Gly 
        915                 920                 925             


Ala Ile Met Ser Ala Leu Ser Asp Thr Glu Ile Gln Arg Glu Ile Gly 
    930                 935                 940                 


Ile Ser Asn Pro Leu His Arg Leu Lys Leu Arg Leu Ala Ile Gln Glu 
945                 950                 955                 960 


Met Val Ser Leu Thr Ser Pro Ser Ala Pro Pro Thr Ser Arg Thr Pro 
                965                 970                 975     


Ser Gly Asn Val Trp Val Thr His Glu Glu Met Glu Asn Leu Ala Ala 
            980                 985                 990         


Pro Ala Lys Thr Lys Glu Ser Glu  Glu Gly Ser Trp Ala  Gln Cys Pro 
        995                 1000                 1005             


Val Phe  Leu Gln Thr Leu Ala  Tyr Gly Asp Met Asn  His Glu Trp 
    1010                 1015                 1020             


Ile Gly  Asn Glu Trp Leu Pro  Ser Leu Gly Leu Pro  Gln Tyr Arg 
    1025                 1030                 1035             


Ser Tyr  Phe Met Glu Cys Leu  Val Asp Ala Arg Met  Leu Asp His 
    1040                 1045                 1050             


Leu Thr  Lys Lys Asp Leu Arg  Val His Leu Lys Met  Val Asp Ser 
    1055                 1060                 1065             


Phe His  Arg Thr Ser Leu Gln  Tyr Gly Ile Met Cys  Leu Lys Arg 
    1070                 1075                 1080             


Leu Asn  Tyr Asp Arg Lys Glu  Leu Glu Arg Arg Arg  Glu Ala Ser 
    1085                 1090                 1095             


Gln His  Glu Ile Lys Asp Val  Leu Val Trp Ser Asn  Asp Arg Val 
    1100                 1105                 1110             


Ile Arg  Trp Ile Gln Ala Ile  Gly Leu Arg Glu Tyr  Ala Asn Asn 
    1115                 1120                 1125             


Ile Leu  Glu Ser Gly Val His  Gly Ser Leu Ile Ala  Leu Asp Glu 
    1130                 1135                 1140             


Asn Phe  Asp Tyr Ser Ser Leu  Ala Leu Leu Leu Gln  Ile Pro Thr 
    1145                 1150                 1155             


Gln Asn  Thr Gln Ala Arg Gln  Ile Leu Glu Arg Glu  Tyr Asn Asn 
    1160                 1165                 1170             


Leu Leu  Ala Leu Gly Thr Glu  Arg Arg Leu Asp Glu  Ser Asp Asp 
    1175                 1180                 1185             


Lys Asn  Phe Arg Arg Gly Ser  Thr Trp Arg Arg Gln  Phe Pro Pro 
    1190                 1195                 1200             


Arg Glu  Val His Gly Ile Ser  Met Met Pro Gly Ser  Ser Glu Thr 
    1205                 1210                 1215             


Leu Pro  Ala Gly Phe Arg Leu  Thr Thr Thr Ser Gly  Gln Ser Arg 
    1220                 1225                 1230             


Lys Met  Thr Thr Asp Val Ala  Ser Ser Arg Leu Gln  Arg Leu Asp 
    1235                 1240                 1245             


Asn Ser  Thr Val Arg Thr Tyr  Ser Cys 
    1250                 1255         


<210>  2998
<211>  4855
<212>  DNA
<213>  Homosapiens

<400>  2998
ccagagcccg gcttggtccg gtccctctgc ccccatcccg cacccttcca cctcctccga     60

gtcccactcc tcacctagga cgccccaaac tgccatgggt tagggtgggg atcgcgaccc    120

gcgcgaaaga ccagccctgc gcttccgccg ggggacgcgg agcccaaacg ccgctcaccg    180

cttgcgggcg ccgggcatgg ggagtgtggt gtgagcccgc acccggggag gacgcaggag    240

ctgcggagac gggcgcgagg aggaggagag gagtcgtgga ttggaaggac ccgagggagg    300

gagggtgggg aagcgaggga aaagtgaagc tgggaggaga aggcggcgga aggtggagat    360

tgatgcttct gttttttgtt gccgctgctg ccctcgcgct gggagccgag ccggagggaa    420

ggcggtggag agatgattgc agagttggtg agcagcgctc tggggctcgc cttgtatctc    480

aacaccctga gtgcggattt ctgctatgat gacagccgtg ctatcaagac taatcaggac    540

cttctcccag aaactccatg gacgcacatt ttctacaatg atttttgggg gactcttcta    600

acccacagtg gcagccacaa gtcctaccgg ccactctgca ctctttcttt tcgcctgaac    660

catgccattg gagggttgaa tccctggagc taccatcttg tcaatgtcct gttgcatgca    720

gcagtcactg gtctcttcac aagcttctcc aagatcctcc ttggtgatgg atactggaca    780

ttcatggctg gcttgatgtt tgcttctcac cccattcaca cggaggcagt ggcaggaatc    840

gtgggacgag ccgatgtcgg ggccagtctc ttctttctcc tctccttgct ctgctacatt    900

aaacactgtt ctacaagagg ctactcagcc agaacctggg gctggttcct ggggtcagga    960

ctgtgcgcag gatgcagcat gttgtggaag gaacaaggag tgactgttct cgcagtttca   1020

gcagtttatg atgtctttgt ctttcacagg ctgaaaataa aacagatatt acctaccatt   1080

tacaaaagga agaacttgtc gcttttccta agcattagtt tgttaatttt ctggggttcc   1140

tcccttttgg gtgcccggtt atactggatg ggaaacaaac caccaagctt ttccaactcg   1200

gacaaccccg ctgctgattc ggacagcctc ctcacccgca ctctcacctt cttctacttg   1260

ccaaccaaga acctctggct gttgctatgt ccagataccc tcagttttga ttggtcaatg   1320

gatgctgtgc ctctgctcaa aacagtttgt gactggagaa acctacacac tgtggccttc   1380

tatactggac tccttctcct tgcctactat ggtttgaaga gcccgagcgt agacagagaa   1440

tgcaatggga aaactgtaac aaatggcaag cagaatgcaa atggacatag ctgcctttca   1500

gatgtggagt accagaactc agagactaag tccagctttg catccaaagt agaaaatggc   1560

attaaaaacg atgtatcaca gagaacccag cttccttcta cggagaacat tgttgttctg   1620

tctttatctt tgttaatcat accctttgtt cctgccacga acctgttttt ctatgtcggc   1680

tttgtaattg cagagcgagt attatatatt cctagtatgg gcttctgcct actgattaca   1740

gtgggtgcta gagcccttta tgtcaaagtc caaaagcggt tcctcaagag cttgattttt   1800

tatgctacag ctacactaat tgttttttat ggactcaaga ctgcgatcag gaatggagac   1860

tggcagaatg aggaaatgct ttatagatca gggataaaag taaacccagc taaagcatgg   1920

ggtaaccttg gaaatgttct gaagagtcag agcaaaattt ctgaagctga aagcgcctat   1980

agaaatgctt tgtactaccg cagcaacatg gctgacatgc tttataattt agggctactt   2040

ctccaggaga acagcaggtt tgcagaagca ctacattatt ataaattggc cattgggagc   2100

aggcctaccc tggcttctgc atatttaaat accggtatta ttctaatgaa ccaaggaagg   2160

acggaagaag cccgacggac attcttaaag tgttcggaga tcccagatga aaacctaaag   2220

gaccctcatg cacacaagag ctctgttacc agttgtttgt acaacctagg aaagctgtat   2280

catgagcagg gacactatga ggaagccctt agtgtataca aggaagcaat tcagaaaatg   2340

ccaaggcagt ttgccccaca gagcttgtac aacatgatgg gtgaagcata tatgcgttta   2400

agcaaactcc ccgaagcaga gcattggtat atggaatcac tgagatccaa gactgaccac   2460

atccctgctc atctcaccta tgggaagctg ctagctctaa caggtcgtaa gagtgaggct   2520

gaaaagctct tcttgaaggc tattgagctg gatcccacca aaggaaactg ttacatgcat   2580

tatggtcagt ttcttctgga agaagctcgt ctcatagaag cagctgagat ggcaaaaaaa   2640

gcagctgaac tagacagcac agagtttgat gttgtcttca atgctgccca catgctcaga   2700

caggctagcc tcaatgaagc agctgagaag tattatgatc tggcagccag gctgaggcct   2760

aattatccgg ctgctttgat gaacctggga gccattctgc acctcaatgg cagactccag   2820

aaggccgagg ccaactacct gcgggccctg cagctcaagc cagacgatgt catcacacag   2880

tccaatctcc gcaaactgtg gaacatcatg gaaaaacaag gcttaaagac ttctaagacc   2940

tgacacagga ggcagaagcc catcctcctc catttttaaa agctggcttc cttagcagac   3000

agaacttccc agcagtgcta tgacaagagc tggtgttaga cttcaagacc agggcagagg   3060

tcattgaggt cactaccgct tctggaagaa tccactttgc tgtaggcaca gctgttaaca   3120

ccaaaaaggg gaaagccgga aacctcctgg aggatgtcat tgttacccat agactgtaaa   3180

ccagagcact taaaacagaa ccttttggca ttcttaaaaa gggaggggtg ggtgtgtaag   3240

tcacagattt tgttcatttt ctgaaagcta atttcaaaat tatgttgttc cttaaacact   3300

gtgagaggaa gtcagagtgt ccattcaggc atggcaaaca attagggtta agtgttacga   3360

gggagtgata aacacgtagt gtgagtccca gtgagccgcc ggttgtccta acgctgctgt   3420

cttccctgtt tgggacagcc tgcttatcaa tttctgaagc ttagaacact ttttttaata   3480

ctgtgtcaag atctgtcaga atctgctatg tttcttgacc agtgcacata atgttttatg   3540

atttggatgt cagaggcttc attcttttgg acatcatttg ctttttatgt tctgaaaagg   3600

atatggagag tagagctaac catacttcac actcgagttg tatgagggac tggggaggcc   3660

ttatatgtgt caggcaggca ttttttaaat tttaatatcg tcaatatttt cccccaaact   3720

gcccagtaga attcattgta ttaattcttt tgaaattacc tttgaaaata gctattcctg   3780

gagaatgtgc aagcttacat aaggataaag gacaggggag gagtttgtaa gccttgcagt   3840

tccaataact aaccaacagg ttattagaca aaagggaagg tgttttgtgc ttctcagatg   3900

ttgctggttt aggagtgtgt gatgatgctt gccagtgatt ttgtgttttg gaaagggtag   3960

gtatcgaatg ttaatcactt tctaatgggt acctaaacag caatgctgat aaatgttcaa   4020

ggaattattt tcatcttagt ttgttcttct caaaaggcat caaaaacaac ttatttgaag   4080

ctgcaataga gtgtagcatt agcctgcatg tttctaggtc ttctgccaag tgcttttctc   4140

agttgaaaac tatttttcac tagcaaaatt ggtattttat ttcattacct gttagtaact   4200

acttcaatga tcatttcaca agaaaaagac tataaattaa gtagagaaca acatttttat   4260

tgaacatttt tggcttgcaa tcaaactttg ccactaaaaa ttaacttcat aaaacactag   4320

tccgttatca acttcttcac agagaaagta gctatactat accctacata tttatttatt   4380

tattattcta ctatagcaga ataacaaaac ttgatgcatt aagccagttc tttgcaactg   4440

aaaattacct gtttctcctt ccctttcaca ctccatgtat atatgatcag cctctccatt   4500

aaaaagaagc tggacatgca aatacatcat attatgtttt ctccatattt tatgtttttc   4560

tatgtatctg aatacagtgg gataaataat tgaaagtagt gttcctatgg cattagtgtt   4620

tttgtgagaa gggtaaatgt agtgagaaag gttttttcat ggcattaata agaaagccct   4680

tctgtaatat atatattatt ttgtaaacat ttcactgaag ggccaaaagt taaattataa   4740

ctaaatcact gtgttttcag aatgatattt aacaacaaac ccgtggtcaa accaaaatag   4800

tgggttgaag tgtattattc atcttttagt gcattggcaa aaaaaaaaaa aaaaa        4855


<210>  2999
<211>  836
<212>  PRT
<213>  Homosapiens

<400>  2999

Met Ile Ala Glu Leu Val Ser Ser Ala Leu Gly Leu Ala Leu Tyr Leu 
1               5                   10                  15      


Asn Thr Leu Ser Ala Asp Phe Cys Tyr Asp Asp Ser Arg Ala Ile Lys 
            20                  25                  30          


Thr Asn Gln Asp Leu Leu Pro Glu Thr Pro Trp Thr His Ile Phe Tyr 
        35                  40                  45              


Asn Asp Phe Trp Gly Thr Leu Leu Thr His Ser Gly Ser His Lys Ser 
    50                  55                  60                  


Tyr Arg Pro Leu Cys Thr Leu Ser Phe Arg Leu Asn His Ala Ile Gly 
65                  70                  75                  80  


Gly Leu Asn Pro Trp Ser Tyr His Leu Val Asn Val Leu Leu His Ala 
                85                  90                  95      


Ala Val Thr Gly Leu Phe Thr Ser Phe Ser Lys Ile Leu Leu Gly Asp 
            100                 105                 110         


Gly Tyr Trp Thr Phe Met Ala Gly Leu Met Phe Ala Ser His Pro Ile 
        115                 120                 125             


His Thr Glu Ala Val Ala Gly Ile Val Gly Arg Ala Asp Val Gly Ala 
    130                 135                 140                 


Ser Leu Phe Phe Leu Leu Ser Leu Leu Cys Tyr Ile Lys His Cys Ser 
145                 150                 155                 160 


Thr Arg Gly Tyr Ser Ala Arg Thr Trp Gly Trp Phe Leu Gly Ser Gly 
                165                 170                 175     


Leu Cys Ala Gly Cys Ser Met Leu Trp Lys Glu Gln Gly Val Thr Val 
            180                 185                 190         


Leu Ala Val Ser Ala Val Tyr Asp Val Phe Val Phe His Arg Leu Lys 
        195                 200                 205             


Ile Lys Gln Ile Leu Pro Thr Ile Tyr Lys Arg Lys Asn Leu Ser Leu 
    210                 215                 220                 


Phe Leu Ser Ile Ser Leu Leu Ile Phe Trp Gly Ser Ser Leu Leu Gly 
225                 230                 235                 240 


Ala Arg Leu Tyr Trp Met Gly Asn Lys Pro Pro Ser Phe Ser Asn Ser 
                245                 250                 255     


Asp Asn Pro Ala Ala Asp Ser Asp Ser Leu Leu Thr Arg Thr Leu Thr 
            260                 265                 270         


Phe Phe Tyr Leu Pro Thr Lys Asn Leu Trp Leu Leu Leu Cys Pro Asp 
        275                 280                 285             


Thr Leu Ser Phe Asp Trp Ser Met Asp Ala Val Pro Leu Leu Lys Thr 
    290                 295                 300                 


Val Cys Asp Trp Arg Asn Leu His Thr Val Ala Phe Tyr Thr Gly Leu 
305                 310                 315                 320 


Leu Leu Leu Ala Tyr Tyr Gly Leu Lys Ser Pro Ser Val Asp Arg Glu 
                325                 330                 335     


Cys Asn Gly Lys Thr Val Thr Asn Gly Lys Gln Asn Ala Asn Gly His 
            340                 345                 350         


Ser Cys Leu Ser Asp Val Glu Tyr Gln Asn Ser Glu Thr Lys Ser Ser 
        355                 360                 365             


Phe Ala Ser Lys Val Glu Asn Gly Ile Lys Asn Asp Val Ser Gln Arg 
    370                 375                 380                 


Thr Gln Leu Pro Ser Thr Glu Asn Ile Val Val Leu Ser Leu Ser Leu 
385                 390                 395                 400 


Leu Ile Ile Pro Phe Val Pro Ala Thr Asn Leu Phe Phe Tyr Val Gly 
                405                 410                 415     


Phe Val Ile Ala Glu Arg Val Leu Tyr Ile Pro Ser Met Gly Phe Cys 
            420                 425                 430         


Leu Leu Ile Thr Val Gly Ala Arg Ala Leu Tyr Val Lys Val Gln Lys 
        435                 440                 445             


Arg Phe Leu Lys Ser Leu Ile Phe Tyr Ala Thr Ala Thr Leu Ile Val 
    450                 455                 460                 


Phe Tyr Gly Leu Lys Thr Ala Ile Arg Asn Gly Asp Trp Gln Asn Glu 
465                 470                 475                 480 


Glu Met Leu Tyr Arg Ser Gly Ile Lys Val Asn Pro Ala Lys Ala Trp 
                485                 490                 495     


Gly Asn Leu Gly Asn Val Leu Lys Ser Gln Ser Lys Ile Ser Glu Ala 
            500                 505                 510         


Glu Ser Ala Tyr Arg Asn Ala Leu Tyr Tyr Arg Ser Asn Met Ala Asp 
        515                 520                 525             


Met Leu Tyr Asn Leu Gly Leu Leu Leu Gln Glu Asn Ser Arg Phe Ala 
    530                 535                 540                 


Glu Ala Leu His Tyr Tyr Lys Leu Ala Ile Gly Ser Arg Pro Thr Leu 
545                 550                 555                 560 


Ala Ser Ala Tyr Leu Asn Thr Gly Ile Ile Leu Met Asn Gln Gly Arg 
                565                 570                 575     


Thr Glu Glu Ala Arg Arg Thr Phe Leu Lys Cys Ser Glu Ile Pro Asp 
            580                 585                 590         


Glu Asn Leu Lys Asp Pro His Ala His Lys Ser Ser Val Thr Ser Cys 
        595                 600                 605             


Leu Tyr Asn Leu Gly Lys Leu Tyr His Glu Gln Gly His Tyr Glu Glu 
    610                 615                 620                 


Ala Leu Ser Val Tyr Lys Glu Ala Ile Gln Lys Met Pro Arg Gln Phe 
625                 630                 635                 640 


Ala Pro Gln Ser Leu Tyr Asn Met Met Gly Glu Ala Tyr Met Arg Leu 
                645                 650                 655     


Ser Lys Leu Pro Glu Ala Glu His Trp Tyr Met Glu Ser Leu Arg Ser 
            660                 665                 670         


Lys Thr Asp His Ile Pro Ala His Leu Thr Tyr Gly Lys Leu Leu Ala 
        675                 680                 685             


Leu Thr Gly Arg Lys Ser Glu Ala Glu Lys Leu Phe Leu Lys Ala Ile 
    690                 695                 700                 


Glu Leu Asp Pro Thr Lys Gly Asn Cys Tyr Met His Tyr Gly Gln Phe 
705                 710                 715                 720 


Leu Leu Glu Glu Ala Arg Leu Ile Glu Ala Ala Glu Met Ala Lys Lys 
                725                 730                 735     


Ala Ala Glu Leu Asp Ser Thr Glu Phe Asp Val Val Phe Asn Ala Ala 
            740                 745                 750         


His Met Leu Arg Gln Ala Ser Leu Asn Glu Ala Ala Glu Lys Tyr Tyr 
        755                 760                 765             


Asp Leu Ala Ala Arg Leu Arg Pro Asn Tyr Pro Ala Ala Leu Met Asn 
    770                 775                 780                 


Leu Gly Ala Ile Leu His Leu Asn Gly Arg Leu Gln Lys Ala Glu Ala 
785                 790                 795                 800 


Asn Tyr Leu Arg Ala Leu Gln Leu Lys Pro Asp Asp Val Ile Thr Gln 
                805                 810                 815     


Ser Asn Leu Arg Lys Leu Trp Asn Ile Met Glu Lys Gln Gly Leu Lys 
            820                 825                 830         


Thr Ser Lys Thr 
        835     


<210>  3000
<211>  3898
<212>  DNA
<213>  Homosapiens

<400>  3000
ctgttccaga cttctcaggg tttttacagc acaaacaact gcatacggcc cgaggggagg     60

ctgaaaagga cttgtgtgtg gtggttttat tgcctgtcat cactttgctg gcctcctccc    120

gactggagcc tggaggttca cagtggattt ctttctgccg aagacaccaa ggcactgagg    180

aaggatccct tctccttctg ttgactcttt ctatttttat ggtttaagtt tatctattca    240

tggggctgaa aagcgtttgc aaatccatca acggcgaagt gtggcaagcc gcccagcgtc    300

acgtcgtcgc ctgcctgtgg tcaggcattc ctcactccca ccaggcagaa ggtcaataaa    360

aatggaggca agctcttctg gaatcactaa tggaaaaacc aaagtcttcc acccagtggc    420

caaggatgtc aatattcttt ttgatgaatt agaagctgtc agcagtcctt gcaaagatga    480

cgattctctt cttcaccctg gaaacctgac tagtacttca gatgatgcca gcagattgga    540

agccggggga gagacagtgc cagaaagaaa caaatcaaat ggactttact ttcgagatgg    600

aaagtgtcga attgactaca tccttgtgta cagaaaatcc aacccccaga ctgaaaagag    660

agaagtattt gaaagaaaca ttagagcaga aggattgcaa atggagaaag agtcctctct    720

aataaatagt gacattatct ttgtgaagtt gcatgcccca tgggaagtcc ttggaagata    780

tgcagaacaa atgaatgtaa gaatgccttt caggagaaaa atctattacc tgccccgccg    840

ttacaagttc atgagcagga tcgataaaca aataagcagg cttcggagat ggttacctaa    900

gaagccaatg aggctggaca aggagacact gccggacctg gaggagaatg actgctacac    960

tgcccctttc agccagcaaa ggatccatca cttcatcata cacaacaaag aaacgttctt   1020

caacaatgcc acaagaagta gaatcgtgca tcacatttta caaagaataa aatatgaaga   1080

aggaaaaaac aagattggtc tgaatcgttt gcttaccaat ggctcctatg aagctgcgtt   1140

tcccctgcat gagggaagtt atagaagtaa aaactccatt cgaacccatg gagcagaaaa   1200

ccaccgacat ctactctatg agtgctgggc ctcctggggc gtgtggtata aataccaacc   1260

tttggatctt gtaaggcggt actttggaga gaagattggg ttatattttg cctggttggg   1320

ctggtacacc ggcatgctct tcccagctgc cttcattgga ttgtttgtct ttttgtatgg   1380

cgtcaccact ctggatcaca gccaagtcag taaagaagtc tgccaagcta cagatatcat   1440

catgtgtcct gtgtgtgata aatactgtcc attcatgagg ctgtcagaca gctgtgtata   1500

tgccaaggta acccaccttt ttgacaatgg agccactgtc ttctttgctg ttttcatggc   1560

agtctgggca acagttttcc tggagttttg gaaaagacgg cgagcagtaa ttgcttatga   1620

ctgggatttg atagactggg aagaagagga ggaagaaata cgaccccagt ttgaagccaa   1680

gtattccaag aaagagcgga tgaatccaat ttctggaaag ccagaacctt atcaagcatt   1740

tacagataaa tgcagcagac ttatcgtttc tgcatctgga atatttttta tgatctgcgt   1800

ggtgattgct gccgtgttcg ggatcgtcat ttaccgggtg gtgactgtca gcactttcgc   1860

tgcctttaag tgggcgttaa tcaggaataa ctctcaggtt gcaaccacag ggactgctgt   1920

gtgcatcaac ttctgtatca ttatgttgct gaatgtgctc tatgaaaaag ttgccctgct   1980

tctgacgaat ttagaacagc ctcgcacaga gtctgagtgg gagaacagct tcaccctgaa   2040

aatgtttctt tttcagtttg tcaatctgaa cagctccaca ttttacatcg cattcttcct   2100

cggaagattt acaggacacc caggtgccta cttgaggctg ataaacaggt ggagactaga   2160

agagtgccac cctagtggat gccttattga tctgtgtatg caaatgggta ttataatggt   2220

gctaaagcag acctggaata atttcatgga acttggctac ccgttaattc agaattggtg   2280

gactagaaga aaagtacgac aagaacatgg acctgaaagg aaaataagtt tcccacaatg   2340

ggaaaaggac tataaccttc agccgatgaa tgcctatgga ctcttcgatg aatacttaga   2400

aatgattctt cagtttggat tcacaactat ctttgtggca gcttttcccc tagcaccact   2460

tctggcctta ctgaataaca taattgaaat tcgacttgat gcttacaaat ttgtcacaca   2520

gtggaggaga cctttagctt caagggccaa agacatagga atttggtatg gaattcttga   2580

aggcattgga attctctctg ttatcacaaa tgcatttgtc atagcgataa catctgactt   2640

tatccctcgc ttggtgtatg cttataagta tggaccttgt gcaggccaag gagaagctgg   2700

gcaaaagtgc atggttggct atgtgaatgc cagcttgtct gtatttcgaa tttctgactt   2760

tgagaaccga tctgagcctg aatctgatgg cagtgagttc tcggggactc ctcttaagta   2820

ctgcagatac cgggactacc gtgacccgcc tcattcactg gtgccctatg gctacacact   2880

gcagttttgg catgtcctag ctgctcgatt agcttttatc attgtctttg agcacctcgt   2940

gttttgtata aagcacctca tttcatatct gatcccagac ctcccaaaag acctaaggga   3000

tcgaatgaga agagagaagt acttgattca ggagatgatg tatgaagcag aactggaacg   3060

tctccagaag gaacgaaagg agaggaagaa gaatggaaaa gcacaccaca acgagtggcc   3120

gtgaccataa aatagtccct ttccaggcca aggacctgaa ttctgtttac ttcttctggc   3180

tgtgcaaaag cacactcaag tgaatgacta aaaatgcaac cacagtgcat gttgcagata   3240

ccggcggccg caggaggggc agcatccagt agaggactgg cgttggagtc acactgctgt   3300

gaaatcacgt tgcagtccag cgcacaattg ctatctatcc atagaccatt cttgaccaag   3360

caagcatgca cattatgggc agttacattc tcaagttttt aaaatcaagg ggaacttgta   3420

tactgggcct gtttttcagc ctgtttgcta ccttttttgc attctatccc atgtgaattt   3480

tacagacact gggctaaaaa gggtattcag acacatggac acacattcct agaatgtcat   3540

catatggtcc taattccatg tcaccaacaa cacagacaag accctgttta caactttttc   3600

tttccttttt tttaatttta gacctttctg agaagattat tatatatgac atatctatag   3660

ctatgtgtat ggccatagat gtatttctgt gtgtacatat gtatagtcat gtattcctgc   3720

atatgtacat acaaatacag agatatataa agtacataga aattccttac ttgtaaatag   3780

ccaaaaagta ctgacatgag tgaattttca catttaaata gtcatcaata tgaagccatg   3840

attaatgctt gtataatgtg atgcaataaa atttaaaata aatttctgca catggaat     3898


<210>  3001
<211>  920
<212>  PRT
<213>  Homosapiens

<400>  3001

Met Glu Ala Ser Ser Ser Gly Ile Thr Asn Gly Lys Thr Lys Val Phe 
1               5                   10                  15      


His Pro Val Ala Lys Asp Val Asn Ile Leu Phe Asp Glu Leu Glu Ala 
            20                  25                  30          


Val Ser Ser Pro Cys Lys Asp Asp Asp Ser Leu Leu His Pro Gly Asn 
        35                  40                  45              


Leu Thr Ser Thr Ser Asp Asp Ala Ser Arg Leu Glu Ala Gly Gly Glu 
    50                  55                  60                  


Thr Val Pro Glu Arg Asn Lys Ser Asn Gly Leu Tyr Phe Arg Asp Gly 
65                  70                  75                  80  


Lys Cys Arg Ile Asp Tyr Ile Leu Val Tyr Arg Lys Ser Asn Pro Gln 
                85                  90                  95      


Thr Glu Lys Arg Glu Val Phe Glu Arg Asn Ile Arg Ala Glu Gly Leu 
            100                 105                 110         


Gln Met Glu Lys Glu Ser Ser Leu Ile Asn Ser Asp Ile Ile Phe Val 
        115                 120                 125             


Lys Leu His Ala Pro Trp Glu Val Leu Gly Arg Tyr Ala Glu Gln Met 
    130                 135                 140                 


Asn Val Arg Met Pro Phe Arg Arg Lys Ile Tyr Tyr Leu Pro Arg Arg 
145                 150                 155                 160 


Tyr Lys Phe Met Ser Arg Ile Asp Lys Gln Ile Ser Arg Leu Arg Arg 
                165                 170                 175     


Trp Leu Pro Lys Lys Pro Met Arg Leu Asp Lys Glu Thr Leu Pro Asp 
            180                 185                 190         


Leu Glu Glu Asn Asp Cys Tyr Thr Ala Pro Phe Ser Gln Gln Arg Ile 
        195                 200                 205             


His His Phe Ile Ile His Asn Lys Glu Thr Phe Phe Asn Asn Ala Thr 
    210                 215                 220                 


Arg Ser Arg Ile Val His His Ile Leu Gln Arg Ile Lys Tyr Glu Glu 
225                 230                 235                 240 


Gly Lys Asn Lys Ile Gly Leu Asn Arg Leu Leu Thr Asn Gly Ser Tyr 
                245                 250                 255     


Glu Ala Ala Phe Pro Leu His Glu Gly Ser Tyr Arg Ser Lys Asn Ser 
            260                 265                 270         


Ile Arg Thr His Gly Ala Glu Asn His Arg His Leu Leu Tyr Glu Cys 
        275                 280                 285             


Trp Ala Ser Trp Gly Val Trp Tyr Lys Tyr Gln Pro Leu Asp Leu Val 
    290                 295                 300                 


Arg Arg Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe Ala Trp Leu Gly 
305                 310                 315                 320 


Trp Tyr Thr Gly Met Leu Phe Pro Ala Ala Phe Ile Gly Leu Phe Val 
                325                 330                 335     


Phe Leu Tyr Gly Val Thr Thr Leu Asp His Ser Gln Val Ser Lys Glu 
            340                 345                 350         


Val Cys Gln Ala Thr Asp Ile Ile Met Cys Pro Val Cys Asp Lys Tyr 
        355                 360                 365             


Cys Pro Phe Met Arg Leu Ser Asp Ser Cys Val Tyr Ala Lys Val Thr 
    370                 375                 380                 


His Leu Phe Asp Asn Gly Ala Thr Val Phe Phe Ala Val Phe Met Ala 
385                 390                 395                 400 


Val Trp Ala Thr Val Phe Leu Glu Phe Trp Lys Arg Arg Arg Ala Val 
                405                 410                 415     


Ile Ala Tyr Asp Trp Asp Leu Ile Asp Trp Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Ile Arg Pro Gln Phe Glu Ala Lys Tyr Ser Lys Lys Glu Arg Met Asn 
        435                 440                 445             


Pro Ile Ser Gly Lys Pro Glu Pro Tyr Gln Ala Phe Thr Asp Lys Cys 
    450                 455                 460                 


Ser Arg Leu Ile Val Ser Ala Ser Gly Ile Phe Phe Met Ile Cys Val 
465                 470                 475                 480 


Val Ile Ala Ala Val Phe Gly Ile Val Ile Tyr Arg Val Val Thr Val 
                485                 490                 495     


Ser Thr Phe Ala Ala Phe Lys Trp Ala Leu Ile Arg Asn Asn Ser Gln 
            500                 505                 510         


Val Ala Thr Thr Gly Thr Ala Val Cys Ile Asn Phe Cys Ile Ile Met 
        515                 520                 525             


Leu Leu Asn Val Leu Tyr Glu Lys Val Ala Leu Leu Leu Thr Asn Leu 
    530                 535                 540                 


Glu Gln Pro Arg Thr Glu Ser Glu Trp Glu Asn Ser Phe Thr Leu Lys 
545                 550                 555                 560 


Met Phe Leu Phe Gln Phe Val Asn Leu Asn Ser Ser Thr Phe Tyr Ile 
                565                 570                 575     


Ala Phe Phe Leu Gly Arg Phe Thr Gly His Pro Gly Ala Tyr Leu Arg 
            580                 585                 590         


Leu Ile Asn Arg Trp Arg Leu Glu Glu Cys His Pro Ser Gly Cys Leu 
        595                 600                 605             


Ile Asp Leu Cys Met Gln Met Gly Ile Ile Met Val Leu Lys Gln Thr 
    610                 615                 620                 


Trp Asn Asn Phe Met Glu Leu Gly Tyr Pro Leu Ile Gln Asn Trp Trp 
625                 630                 635                 640 


Thr Arg Arg Lys Val Arg Gln Glu His Gly Pro Glu Arg Lys Ile Ser 
                645                 650                 655     


Phe Pro Gln Trp Glu Lys Asp Tyr Asn Leu Gln Pro Met Asn Ala Tyr 
            660                 665                 670         


Gly Leu Phe Asp Glu Tyr Leu Glu Met Ile Leu Gln Phe Gly Phe Thr 
        675                 680                 685             


Thr Ile Phe Val Ala Ala Phe Pro Leu Ala Pro Leu Leu Ala Leu Leu 
    690                 695                 700                 


Asn Asn Ile Ile Glu Ile Arg Leu Asp Ala Tyr Lys Phe Val Thr Gln 
705                 710                 715                 720 


Trp Arg Arg Pro Leu Ala Ser Arg Ala Lys Asp Ile Gly Ile Trp Tyr 
                725                 730                 735     


Gly Ile Leu Glu Gly Ile Gly Ile Leu Ser Val Ile Thr Asn Ala Phe 
            740                 745                 750         


Val Ile Ala Ile Thr Ser Asp Phe Ile Pro Arg Leu Val Tyr Ala Tyr 
        755                 760                 765             


Lys Tyr Gly Pro Cys Ala Gly Gln Gly Glu Ala Gly Gln Lys Cys Met 
    770                 775                 780                 


Val Gly Tyr Val Asn Ala Ser Leu Ser Val Phe Arg Ile Ser Asp Phe 
785                 790                 795                 800 


Glu Asn Arg Ser Glu Pro Glu Ser Asp Gly Ser Glu Phe Ser Gly Thr 
                805                 810                 815     


Pro Leu Lys Tyr Cys Arg Tyr Arg Asp Tyr Arg Asp Pro Pro His Ser 
            820                 825                 830         


Leu Val Pro Tyr Gly Tyr Thr Leu Gln Phe Trp His Val Leu Ala Ala 
        835                 840                 845             


Arg Leu Ala Phe Ile Ile Val Phe Glu His Leu Val Phe Cys Ile Lys 
    850                 855                 860                 


His Leu Ile Ser Tyr Leu Ile Pro Asp Leu Pro Lys Asp Leu Arg Asp 
865                 870                 875                 880 


Arg Met Arg Arg Glu Lys Tyr Leu Ile Gln Glu Met Met Tyr Glu Ala 
                885                 890                 895     


Glu Leu Glu Arg Leu Gln Lys Glu Arg Lys Glu Arg Lys Lys Asn Gly 
            900                 905                 910         


Lys Ala His His Asn Glu Trp Pro 
        915                 920 


<210>  3002
<211>  3983
<212>  DNA
<213>  Homosapiens

<400>  3002
gtgtagattc gctggaagca gctggaggct ccagttctca tctgctcagg tgtccccggc     60

gccttggcga actcggccac tccagttcct cacgtggtga gcactcaggg cagcgggtcg    120

attttccgag gtcccatacc tgggtttgag gggcgcggct cgcagcggcg ggtgcagggg    180

cgactgccag ccctcacccc gcctcggggt gcgttcggag gccgacacct ggaggacgcc    240

tccagtcccc gcgggacgcc acgcctgcgc gccagggatc cgggataaga agtgcgcgcc    300

gggctccggc tgcgcgccgc ggggccacca gtttgcgcgc agggctcagg cgaccgtgcg    360

gccatggaca cgccacgggg catcggcacc ttcgtggtgt gggactacgt ggtgttcgcg    420

ggcatgctgg tcatctcggc cgccatcggc atctactacg ccttcgctgg gggcggccag    480

cagacctcca aggacttcct gatgggcggc cgcagaatga ccgcagtgcc cgtggcgctg    540

tccctcaccg ctagcttcat gtcagccgtc actgtcctgg gcaccccctc cgaggtctac    600

cgttttgggg ccatttttag catctttgcc ttcacctact tctttgtggt ggtcatcagc    660

gcggaggtct tcctcccggt gttctacaaa ctgggaatta ccagcaccta cgagtattta    720

gaacttcgat ttaacaaatg tgttcgtctc tgtggaacag tcctcttcat tgttcaaaca    780

attctgtata ctggaattgt tatttatgcc cctgccctgg ctttgaatca agtcacagga    840

tttgatctgt ggggcgcggt agtggcaacg ggggtggtct gcacattcta ctgcacactg    900

ggtggtctta aagcagttat ctggacagat gtttttcaaa ttgggatcat ggtggctgga    960

tttgcatccg tgattataca ggctgtggtg atgcaaggtg gaatcagcac tattttaaat   1020

gatgcctatg atggtggaag attaaatttc tggaatttta atcctaaccc tttgcaaaga   1080

cacaccttct ggacaattat tataggaggg accttcacat ggaccagcat ctacggtgtc   1140

aaccaatccc aggtgcagag atatatttct tgtaaaagca gattccaggc aaaactgtct   1200

ctctacatca atcttgtggg actctgggca atcctcacat gctcagtgtt ttgtgggctc   1260

gccctatatt ccaggtacca tgactgtgat ccttggacag ccaagaaagt gtctgcacca   1320

gaccagctca tgccttattt ggtactggac attctgcaag attatccagg acttcctgga   1380

ctttttgtgg cctgtgctta cagtgggaca ttaagcacag tgtcctccag tattaatgcc   1440

ttagcagcag taactgtgga agatctaatc aaaccttact tcagatcgct ctcagaaagg   1500

tctctgtctt ggatttccca aggaatgagt gtggtgtatg gagccctgtg tattggaatg   1560

gctgcgctgg cgtcacttat gggagctttg ttgcaggcag cactcagcgt atttggtatg   1620

gttggtggac cacttatggg cctgttcgct ttgggcattt tggttccctt tgccaactca   1680

attggagcac ttgttggtct gatggctgga tttgccattt ctctatgggt tggaattgga   1740

gctcaaatat atcctccact tcctgagaga acattgccat tgcaccttga tatccaaggc   1800

tgtaacagca cctacaatga gacaaatttg attacaacca cagaaatgcc atttactact   1860

agtgtttttc aaatatacaa tgttcaaagg actccactga tggataactg gtattcttta   1920

tcatatctgt acttcagcac tgttggaact ttggtaacat tattagtggg gatacttgtc   1980

agtttatcaa caggaggaag aaaacagaac ttagacccca gatatatact aaccaaagag   2040

gactttttat ccaattttga tatttttaag aaaaagaagc atgttttgag ctataaatca   2100

catccagtgg aagatggtgg aactgataat cctgctttca accacattga attgaactca   2160

gatcagagtg gcaagagcaa tgggactcgt ttgtgaagct gctctgatac tagatatcct   2220

taaatgatgt ttcaatttta tatgttttct aagataattg gatcaggttt tctttgtgtg   2280

tgtgtgtgtg tgttgtatca tgagtgtttg ggggataagt ttttgttaaa acaaagtctg   2340

gactatcttc atttactaca tcattaattg atgttactct ggagtttaga attctggcat   2400

tgacatttcc ctctctttcc tttatttcga tgaagctata attgtgaaaa ttgtaactac   2460

atagatgctg aaaggctaat acacacatat gcacatgtat ttgattgtca aaggtatatt   2520

cttaaatttg ggtattattg aaaatatttt ccatgccttg gtgctagcat ataagtttgg   2580

aagtttgcca acatcacaat tcatcttgaa aagagctttt ttccctccta ccacatacac   2640

cattcttagg gagcaatgag gtaacaggtc tgtgttgtct agatctttgc tttttatccc   2700

cctatcagtc cagggcatat actaacctgc aaactgattc tgaatcagga aggtggtaat   2760

caataagtat tctggctggg aaagaccgtg ggcccaatga tcaaagtctt cttggtgctg   2820

ttcattaatt cttgtgcctt ttggcttgtt ttctagagtt tctgggcttt ggctgctgat   2880

actgcctttc ttagactgta atttttatct gcatgcccag tttctgacct atcaacttgg   2940

gttttattgt gcactctaac tgagcttgtc ttcataattt tctgtttatt gccctgggct   3000

tggatatgtc tcaagacact catgtgaatc atgccacccc aaatcctggc ttatcaagtc   3060

ccagactata aattatgaac tcccattagc ttggtactaa catatacttg atgtaggtat   3120

ttatggactt gatgatccaa gaatattata ttcttcaaaa tggttaagct ccatggagtt   3180

agatgactac acttaatgct attaagttga acttttgaat gtcaactaat ttgcaatcaa   3240

ttaaagatac atatgcctag aaattttgaa atttcggtat atttatccag ttaaagggct   3300

aaattatata agcaaacact acttttttta aaacgtctgg actcaaaaaa tgctttgttc   3360

catgttttaa aatttttaag tagcagtctc aaagttgctt agctgtttat tttgctatgt   3420

tcctagctaa gagtttggtt ataggagttc atcaataact tattttttgt acagttccca   3480

cattagatac tgtttaaaag ttctttttta aactcaattt tttttagaaa cataagagaa   3540

atatttagat acatacaaat gtttttatga ttaaataatt ttatgcttat tttctgatac   3600

gtgttattta ggtaatcatg ccctgtacat ttagaggttg ctaactgaca atgttaagaa   3660

atttaaaaaa aaaaaaagcc tgggcatgat ggctcatgct tgtaatctga acatttggga   3720

ggctgaggca ggaagatcgc ttgaggtcca gagtttaagt ccagcctgga aacatagtta   3780

gacctcatct ctacaaaaat aaaaaataaa aataaaaaaa acttagctag gcatgttgcc   3840

acatacttgt agtcccagtt attagggaag ctgaggtggg aggatagctt aagcccagga   3900

tttcaaggct gcattgagct atgattacac cactgcactc cagcctgggt aacagagtga   3960

aatcttgtct ctgggaaaaa aaa                                           3983


<210>  3003
<211>  610
<212>  PRT
<213>  Homosapiens

<400>  3003

Met Asp Thr Pro Arg Gly Ile Gly Thr Phe Val Val Trp Asp Tyr Val 
1               5                   10                  15      


Val Phe Ala Gly Met Leu Val Ile Ser Ala Ala Ile Gly Ile Tyr Tyr 
            20                  25                  30          


Ala Phe Ala Gly Gly Gly Gln Gln Thr Ser Lys Asp Phe Leu Met Gly 
        35                  40                  45              


Gly Arg Arg Met Thr Ala Val Pro Val Ala Leu Ser Leu Thr Ala Ser 
    50                  55                  60                  


Phe Met Ser Ala Val Thr Val Leu Gly Thr Pro Ser Glu Val Tyr Arg 
65                  70                  75                  80  


Phe Gly Ala Ile Phe Ser Ile Phe Ala Phe Thr Tyr Phe Phe Val Val 
                85                  90                  95      


Val Ile Ser Ala Glu Val Phe Leu Pro Val Phe Tyr Lys Leu Gly Ile 
            100                 105                 110         


Thr Ser Thr Tyr Glu Tyr Leu Glu Leu Arg Phe Asn Lys Cys Val Arg 
        115                 120                 125             


Leu Cys Gly Thr Val Leu Phe Ile Val Gln Thr Ile Leu Tyr Thr Gly 
    130                 135                 140                 


Ile Val Ile Tyr Ala Pro Ala Leu Ala Leu Asn Gln Val Thr Gly Phe 
145                 150                 155                 160 


Asp Leu Trp Gly Ala Val Val Ala Thr Gly Val Val Cys Thr Phe Tyr 
                165                 170                 175     


Cys Thr Leu Gly Gly Leu Lys Ala Val Ile Trp Thr Asp Val Phe Gln 
            180                 185                 190         


Ile Gly Ile Met Val Ala Gly Phe Ala Ser Val Ile Ile Gln Ala Val 
        195                 200                 205             


Val Met Gln Gly Gly Ile Ser Thr Ile Leu Asn Asp Ala Tyr Asp Gly 
    210                 215                 220                 


Gly Arg Leu Asn Phe Trp Asn Phe Asn Pro Asn Pro Leu Gln Arg His 
225                 230                 235                 240 


Thr Phe Trp Thr Ile Ile Ile Gly Gly Thr Phe Thr Trp Thr Ser Ile 
                245                 250                 255     


Tyr Gly Val Asn Gln Ser Gln Val Gln Arg Tyr Ile Ser Cys Lys Ser 
            260                 265                 270         


Arg Phe Gln Ala Lys Leu Ser Leu Tyr Ile Asn Leu Val Gly Leu Trp 
        275                 280                 285             


Ala Ile Leu Thr Cys Ser Val Phe Cys Gly Leu Ala Leu Tyr Ser Arg 
    290                 295                 300                 


Tyr His Asp Cys Asp Pro Trp Thr Ala Lys Lys Val Ser Ala Pro Asp 
305                 310                 315                 320 


Gln Leu Met Pro Tyr Leu Val Leu Asp Ile Leu Gln Asp Tyr Pro Gly 
                325                 330                 335     


Leu Pro Gly Leu Phe Val Ala Cys Ala Tyr Ser Gly Thr Leu Ser Thr 
            340                 345                 350         


Val Ser Ser Ser Ile Asn Ala Leu Ala Ala Val Thr Val Glu Asp Leu 
        355                 360                 365             


Ile Lys Pro Tyr Phe Arg Ser Leu Ser Glu Arg Ser Leu Ser Trp Ile 
    370                 375                 380                 


Ser Gln Gly Met Ser Val Val Tyr Gly Ala Leu Cys Ile Gly Met Ala 
385                 390                 395                 400 


Ala Leu Ala Ser Leu Met Gly Ala Leu Leu Gln Ala Ala Leu Ser Val 
                405                 410                 415     


Phe Gly Met Val Gly Gly Pro Leu Met Gly Leu Phe Ala Leu Gly Ile 
            420                 425                 430         


Leu Val Pro Phe Ala Asn Ser Ile Gly Ala Leu Val Gly Leu Met Ala 
        435                 440                 445             


Gly Phe Ala Ile Ser Leu Trp Val Gly Ile Gly Ala Gln Ile Tyr Pro 
    450                 455                 460                 


Pro Leu Pro Glu Arg Thr Leu Pro Leu His Leu Asp Ile Gln Gly Cys 
465                 470                 475                 480 


Asn Ser Thr Tyr Asn Glu Thr Asn Leu Ile Thr Thr Thr Glu Met Pro 
                485                 490                 495     


Phe Thr Thr Ser Val Phe Gln Ile Tyr Asn Val Gln Arg Thr Pro Leu 
            500                 505                 510         


Met Asp Asn Trp Tyr Ser Leu Ser Tyr Leu Tyr Phe Ser Thr Val Gly 
        515                 520                 525             


Thr Leu Val Thr Leu Leu Val Gly Ile Leu Val Ser Leu Ser Thr Gly 
    530                 535                 540                 


Gly Arg Lys Gln Asn Leu Asp Pro Arg Tyr Ile Leu Thr Lys Glu Asp 
545                 550                 555                 560 


Phe Leu Ser Asn Phe Asp Ile Phe Lys Lys Lys Lys His Val Leu Ser 
                565                 570                 575     


Tyr Lys Ser His Pro Val Glu Asp Gly Gly Thr Asp Asn Pro Ala Phe 
            580                 585                 590         


Asn His Ile Glu Leu Asn Ser Asp Gln Ser Gly Lys Ser Asn Gly Thr 
        595                 600                 605             


Arg Leu 
    610 


<210>  3004
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3004
cccaggggct caagccgcac gtgagaaagt ctgggcatct gggattcgga gagtatagcc     60

tgtgagccgc tttcccctcc ttactgtcgg ttgcatccct tcgacactcc cgaggccgtc    120

gcgggccact ggccctctgc agccatgaag acaaagcccg tttcccacaa gaccgagaac    180

acctaccggt ttcttacatt tgctgaacga ctggggaatg ttaatattga tattattcac    240

cggattgata gaactgcaag ctatgaggag gaggttgaaa cctacttttt tgagggtctg    300

ctgaaatgga gagaattaaa cctcacagaa cacttcggaa aattttacaa agaagttatt    360

gacaaatgcc aatcattcaa tcagttggtg tatcaccaaa acgagatagt tcagagtttg    420

aagactcacc tgcaagttaa gaacagtttt gcctatcaac cccttttgga tttggttgta    480

cagttggcac gagatctgca gatggatttc tacccacact ttccagagtt ttttttgact    540

atcacctcga tcctggagac tcaggacaca gagttgttag aatgggcttt cacctcgtta    600

tcatatcttt ataagtacct gtggagactg atggtgaagg acatgtccag tatatacagc    660

atgtacagca cactcctggc tcataaaaaa ctacatataa gaaattttgc tgctgaaagt    720

tttacttttt tgatgagaaa ggtctctgat aaaaacgcac ttttcaattt aatgtttctt    780

gatcttgata aacatccaga aaaagttgaa ggtgttggac agttgctctt tgaaatgtgc    840

aaaggagtta gaaatatgtt tcactcctgt acaggccagg cagtgaagct aattttgcga    900

aagctaggac cagtcactga aacagaaact caactaccat ggatgttaat tggagaaaca    960

ctcaaaaaca tggtcaaatc cactgtatcc tacatctcca aggaacattt tggtacattt   1020

tttgaatgtt tgcaagaatc gctcttggat ctacacacaa aagtaacaaa aactaactgt   1080

tgtgaaagtt ctgaacagat taaaaggttg ttggaaacat accttatact tgtaaaacat   1140

ggaagtggga caaagatacc cacgcctgct gatgtctgta aggtgttatc tcaaacactg   1200

caagtagcca gtctctccac atcttgctgg gagaccctct tggatgtaat ttctgctttg   1260

atcctgggtg aaaatgtttc cttgccggag accctcatca aagaaaccat agaaaaaata   1320

tttgagagca gatttgaaaa acgtttaatt ttcagttttt ctgaagtcat gtttgccatg   1380

aagcagtttg agcagctttt tctaccaagc tttctgtcat atattgtgaa ttgcttctta   1440

attgatgatg ctgtagtcaa agatgaagct ctggccattc tggccaagct cattctgaac   1500

aaagcagcac ctcccactgc tggctcgatg gcaattgaaa agtaccctct ggttttctca   1560

ccgcagatgg tgggattcta tataaagcag aagaagacta gatccaaggg aagaaacgaa   1620

cagtttccag tattggacca tcttttatct ataattaagt tacccccaaa taaagatact   1680

acttaccttt cacaatcttg ggcagccctc gtggtgttac ctcatattag acctcttgag   1740

aaagagaagg tgataccact cgtcaccggc ttcatagagg cactcttcat gactgttgac   1800

aaaggaagct ttgggaaagg aaacttattt gttctttgtc aagctgtaaa tactctacta   1860

agtttggaag aatcttctga acttcttcat ttggttcctg tggaacgtgt gaagaattta   1920

gtattaacct ttcccctgga gccatctgtg ttgctgttga ctgatctcta ttatcagaga   1980

ttagccttgt gtggctgcaa agggccactt tcccaggagg ctttaatgga attatttccc   2040

aagttacaag caaacatttc aactggtgta tccaagattc ggcttttgac aataaggatc   2100

ctaaaccatt ttgatgtcca gcttccagaa tcaatggagg atgatgggct ctcagagcgg   2160

cagtctgtct ttgctatatt acgccaggca gaacttgttc cagcaactgt gaatgattat   2220

agagagaagc ttcttcattt gagaaaacta agacatgatg tggtacagac tgctgtccct   2280

gatgggccgt tacaggaggt gccgcttcgt tatttgttag gcatgctata tattaatttc   2340

agtgcactct gggatcctgt tattgaactc ataagttctc atgcacacga aatggaaaat   2400

aagcaatttt ggaaagtcta ctatgagcat ctagaaaaag cagctacgca tgctgagaag   2460

gaactacaga atgatatgac agatgagaag tccgttggag atgaaagttg ggagcagacc   2520

caggaaggag atgttggagc tctttatcat gagcagttag cattgaaaac tgactgtcag   2580

gaaagacttg accacaccaa cttcagattc ctgctctgga gagctctgac caaattccca   2640

gaaagagtag agccacggtc cagggagctt tccccgcttt tcttgagatt tatcaacaat   2700

gagtattacc cagcagatct gcaagttgct ccaacccagg atctacggag aaaaggcaaa   2760

gggatggtgg cagaggaaat cgaagaggaa cctgccgcag gagatgatga agagttggag   2820

gaagaggcag tgccccaaga tgaatcctca cagaagaaaa agacgaggag agctgcagca   2880

aagcaattaa ttgctcattt gcaagttttc tctaaatttt caaatccacg ggccttatat   2940

ctggaatcca aactatatga gttatatctt cagttgttgc tacaccaaga tcaaatggtg   3000

caaaaaataa ccttggattg cataatgaca tataaacatc ctcatgtcct cccttacagg   3060

gaaaacttac aaaggttgct tgaagacaga agctttaagg aagagatagt gcattttagc   3120

atttcagaag ataatgctgt agtgaaaaca gcccaccgag cagatctatt tcctattctg   3180

atgagaattt tgtatgggcg aatgaagaat aagactggga gtaaaactca ggggaaatct   3240

gcttcaggca cccgcatggc cattgtcctg cggttcctgg ccgggaccca acctgaggag   3300

atccagatat tcttagacct gctgtttgaa cctgtgaggc atttcaagaa tggagagtgc   3360

cattctgcag tcattcaagc agtagaagac ttggatttgt ctaaagttct tcctttaggt   3420

cgtcagcacg gtatcttaaa cagccttgag atagtattga aaaacattag tcatctgatc   3480

agcgcatacc tgccgaagat tttgcagata ctgctctgta tgacagcaac cgtatcacac   3540

atccttgacc aacgagaaaa gatacagctg agatttatta atccattgaa aaatttaaga   3600

cgtcttggaa tcaaaatggt aactgatatc tttttggact gggaatcata tcagtttaga   3660

acagaagaaa ttgatgctgt gtttcatggt gcagtttggc cccagatcag caggcttgga   3720

tctgagagtc aatattctcc tactcctctg ctgaaactga tcagtatctg gagcagaaac   3780

gcaagatatt tccctttgct ggctaaacag aagcctgggc acccagaatg tgatatcctg   3840

accaatgttt ttgcaattct ctcagcgaag aatctttctg atgccacagc cagtattgta   3900

atggacatag ttgatgacct tcttaacctt ccagatttcg agcctacaga aacagttttg   3960

aacttgctgg taactggatg tgtataccct ggcatagcag aaaacatcgg tgagtctatc   4020

acaataggag gaagattaat tctacctcat gtacctgcaa ttcttcagta tctcagcaaa   4080

accacaataa gcgcagaaaa ggtgaaaaag aaaaagaata gagcacaagt cagtaaagag   4140

cttggcattc tttcaaagat cagcaagttt atgaaagaca aagaacaaag ttctgtactc   4200

attacgcttc tccttccatt cctccaccgt ggcaatattg ctgaggatac agaggttgat   4260

attctggtga cagtacaaaa cttgttaaag cattgtgtgg accctacaag cttcctcaag   4320

cctatagcaa aacttttctc agttattaag aacaaattgt caagaaaatt gctttgtacg   4380

gtttttgaga ctctttctga ttttgagagt gggttaaaat atattactga tgttgtcaag   4440

cttaacgcct tcgatcaaag acatcttgat gatatcaact tcgacgttcg ctttgagact   4500

ttccagacca tcacctctta cattaaagaa atgcaaattg tggatgttaa ctacctaatt   4560

ccagttatgc ataattgttt ctataatcta gagttaggag atatgagttt aagtgataat   4620

gccagcatgt gcctgatgag tatcatcaaa aagctacctg ccttgaatgt cacagagaaa   4680

gactatagag aaatcatcca ccgttcactc ctggagaaat tgagaaaagg tctgaagagc   4740

cagacagaga gtattcagca ggattatacc acaatacttt cctgtttaat tcaaaccttt   4800

ccaaaccaac tggaattcaa agacttggta caacttactc attaccatga cccagaaatg   4860

gacttctttg agaacatgaa gcacattcag atccacagaa gagcaagagc cttgaagaaa   4920

cttgcaaaac aactaatgga aggcaaagtt gttctgtctt ctaaatctct tcagaattac   4980

atcatgcctt atgccatgac tccaattttt gatgagaaaa tgctcaagca tgaaaatata   5040

accactgctg ccacagagat tattggagcc atttgcaaac atctctcttg gtcagcgtat   5100

atgtattact tgaaacattt cattcatgtc ttacaaacgg gacagatcaa tcaaaaactg   5160

ggtgtcagtt tgctagtaat agtgttagaa gcattccact ttgaccacaa aactcttgaa   5220

gaacaaatgg gaaaaattga gaatgaagaa aacgcaattg aagcaattga gttaccagag   5280

cctgaggcca tggaattaga gcgtgtggat gaggaagaga aggaatatac atgcaagagt   5340

ttgtcagaca acggacaacc gggaacccct gatccagctg actctggagg aacatcagct   5400

aaagaatccg agtgtatcac aaagcctgtc tctttccttc ctcaaaacaa ggaagaaata   5460

gagagaacaa ttaaaaatat ccaaggaacc ataaccgggg atattctccc caggctacat   5520

aaatgccttg catctacgac taaaagggaa gaagaacaca agcttgtcaa gtcaaaggtt   5580

gtgaatgatg aggaagtcgt tcgagttcca ttagcttttg ccatggttaa actaatgcag   5640

tcccttccac aagaagttat ggaagctaat ctgccaagta ttttgctgaa agtgtgtgcc   5700

ctactcaaga acagagccca agaaatcaga gacattgcac gcagcactct tgcgaaaata   5760

atagaggatc ttggtgtgca cttcctccaa tatgttttaa aagaattaca gactactctt   5820

gtccgtggat accaggtcca tgtgctgact ttcaccgttc acatgctgct gcaaggcctc   5880

accaataagc tgcaggtcgg agatctggac tcttgtttag atataatgat tgagattttt   5940

aaccatgagt tgtttggtgc tgttgctgaa gagaaggaag taaagcagat cctctccaaa   6000

gtcatggaag cacgaagaag caaaagttac gactcttatg aaatcctcgg caagtttgta   6060

ggaaaagatc aggttacaaa actcatcctt ccattaaaag agatcttaca aaataccacg   6120

agtttgaaac tggcccggaa agttcatgaa actttacgcc gaatcacagt gggattaatt   6180

gtaaatcagg aaatgacagc tgaatccatt ctattactca gttatggttt gatcagtgaa   6240

aatcttcccc tgttaacaga gaaagaaaaa aatccagtag ccccagcacc agatccacgt   6300

ctaccacccc agagctgcct tctgcttccc ccaactccag ttcgaggtgg acagaaagct   6360

gttgtgagca ggaaaaccaa catgcacata tttattgagt ccgggcttcg gctgctgcat   6420

ctgagtctga agacttccaa gatcaagtct tcaggtgaat gtgtcctgga aatgctggat   6480

ccttttgtgt ctctcctcat agactgcctg ggctccatgg atgtgaaggt gatcacaggt   6540

gctttacagt gcctcatctg ggtcttgagg ttcccgctac cttccataga aacaaaagca   6600

gagcagctga caaaacacct cttccttctg ctgaaggact atgcaaagct cggggccgcc   6660

aggggccaga acttccacct tgtggtcaat tgtttcaagt gtgtgaccat acttgtcaag   6720

aaagtcaagt cttaccagat aactgaaaaa cagctccaag ttctactggc ctatgctgag   6780

gaggacattt atgatacttc aagacaagcc actgcctttg gtcttctgaa ggcaatttta   6840

tcaagaaagc tgttggtccc agaaatcgat gaggtcatgc ggaaagtatc caagttggca   6900

gtctctgcac aaagcgaacc tgccagggtc cagtgtagac aggtttttct gaaatatatt   6960

cttgactatc ccctgggtga caaattgaga ccaaacttgg aattcatgct cgctcaactg   7020

aattacgaac atgagaccgg gagagagtcc accttggaaa tgatcgccta tctctttgac   7080

acgttccctc aggggctgct ccatgagaac tgcggaatgt tctttatccc tctttgtcta   7140

atgacgatca atgatgactc tgccacgtgc aaaaagatgg catccatgac aatcaagtcc   7200

ctacttggta aaatcagcct cgagaaaaaa gattggctgt ttgatatggt taccacttgg   7260

tttggagcaa aaaagcgctt aaatagacaa cttgctgccc tgatctgtgg cttgtttgtg   7320

gaaagtgaag gagttgattt tgagaaaaga cttggaactg tccttcctgt gattgaaaag   7380

gaaattgatc ctgaaaactt taaagatatc atggaagaaa ctgaagaaaa agctgcagat   7440

cgccttctgt ttagttttct tacactgata actaaactta tcaaggaatg taatattatt   7500

cagtttacca aacccgctga gactttgagt aaaatctgga gtcatgtgca ttctcacctg   7560

agacatccac acaactgggt gtggctcaca gcagcccaga tttttggatt actctttgcc   7620

tcttgccagc cagaggagct tattcaaaaa tggaatacca aaaagaccaa aaaacacctc   7680

ccagaacctg tagcaatcaa gttcctagcc agtgaccttg accaaaagat gaaaagtatc   7740

tctctcgcct cttgccatca attgcattcc aaattcttgg atcagtctct aggagaacag   7800

gttgttaaga atttgttgtt cgcagccaaa gtcttgtatt tactggaact ttattgtgag   7860

gataagcaaa gtaagataaa agaagacctg gaagaacaag aagctttaga agatggtgtg   7920

gcctgtgcag atgagaaggc ggagtctgac ggagaagaga aggaagaggt gaaggaagag   7980

ctcggcaggc cggccacgct gctgtggttg atccagaagc tgtcccggat tgcaaaactg   8040

gaagctgctt attcgccgag aaacccctta aagagaacat gcatctttaa gttcctcggc   8100

gccgtagcaa tggatcttgg gatagacaag gtaaagccgt atctcccaat gatcatagct   8160

cctttgtttc gggaactcaa cagcacctat tc                                 8192


<210>  3005
<211>  2785
<212>  PRT
<213>  Homosapiens

<400>  3005

Met Lys Thr Lys Pro Val Ser His Lys Thr Glu Asn Thr Tyr Arg Phe 
1               5                   10                  15      


Leu Thr Phe Ala Glu Arg Leu Gly Asn Val Asn Ile Asp Ile Ile His 
            20                  25                  30          


Arg Ile Asp Arg Thr Ala Ser Tyr Glu Glu Glu Val Glu Thr Tyr Phe 
        35                  40                  45              


Phe Glu Gly Leu Leu Lys Trp Arg Glu Leu Asn Leu Thr Glu His Phe 
    50                  55                  60                  


Gly Lys Phe Tyr Lys Glu Val Ile Asp Lys Cys Gln Ser Phe Asn Gln 
65                  70                  75                  80  


Leu Val Tyr His Gln Asn Glu Ile Val Gln Ser Leu Lys Thr His Leu 
                85                  90                  95      


Gln Val Lys Asn Ser Phe Ala Tyr Gln Pro Leu Leu Asp Leu Val Val 
            100                 105                 110         


Gln Leu Ala Arg Asp Leu Gln Met Asp Phe Tyr Pro His Phe Pro Glu 
        115                 120                 125             


Phe Phe Leu Thr Ile Thr Ser Ile Leu Glu Thr Gln Asp Thr Glu Leu 
    130                 135                 140                 


Leu Glu Trp Ala Phe Thr Ser Leu Ser Tyr Leu Tyr Lys Tyr Leu Trp 
145                 150                 155                 160 


Arg Leu Met Val Lys Asp Met Ser Ser Ile Tyr Ser Met Tyr Ser Thr 
                165                 170                 175     


Leu Leu Ala His Lys Lys Leu His Ile Arg Asn Phe Ala Ala Glu Ser 
            180                 185                 190         


Phe Thr Phe Leu Met Arg Lys Val Ser Asp Lys Asn Ala Leu Phe Asn 
        195                 200                 205             


Leu Met Phe Leu Asp Leu Asp Lys His Pro Glu Lys Val Glu Gly Val 
    210                 215                 220                 


Gly Gln Leu Leu Phe Glu Met Cys Lys Gly Val Arg Asn Met Phe His 
225                 230                 235                 240 


Ser Cys Thr Gly Gln Ala Val Lys Leu Ile Leu Arg Lys Leu Gly Pro 
                245                 250                 255     


Val Thr Glu Thr Glu Thr Gln Leu Pro Trp Met Leu Ile Gly Glu Thr 
            260                 265                 270         


Leu Lys Asn Met Val Lys Ser Thr Val Ser Tyr Ile Ser Lys Glu His 
        275                 280                 285             


Phe Gly Thr Phe Phe Glu Cys Leu Gln Glu Ser Leu Leu Asp Leu His 
    290                 295                 300                 


Thr Lys Val Thr Lys Thr Asn Cys Cys Glu Ser Ser Glu Gln Ile Lys 
305                 310                 315                 320 


Arg Leu Leu Glu Thr Tyr Leu Ile Leu Val Lys His Gly Ser Gly Thr 
                325                 330                 335     


Lys Ile Pro Thr Pro Ala Asp Val Cys Lys Val Leu Ser Gln Thr Leu 
            340                 345                 350         


Gln Val Ala Ser Leu Ser Thr Ser Cys Trp Glu Thr Leu Leu Asp Val 
        355                 360                 365             


Ile Ser Ala Leu Ile Leu Gly Glu Asn Val Ser Leu Pro Glu Thr Leu 
    370                 375                 380                 


Ile Lys Glu Thr Ile Glu Lys Ile Phe Glu Ser Arg Phe Glu Lys Arg 
385                 390                 395                 400 


Leu Ile Phe Ser Phe Ser Glu Val Met Phe Ala Met Lys Gln Phe Glu 
                405                 410                 415     


Gln Leu Phe Leu Pro Ser Phe Leu Ser Tyr Ile Val Asn Cys Phe Leu 
            420                 425                 430         


Ile Asp Asp Ala Val Val Lys Asp Glu Ala Leu Ala Ile Leu Ala Lys 
        435                 440                 445             


Leu Ile Leu Asn Lys Ala Ala Pro Pro Thr Ala Gly Ser Met Ala Ile 
    450                 455                 460                 


Glu Lys Tyr Pro Leu Val Phe Ser Pro Gln Met Val Gly Phe Tyr Ile 
465                 470                 475                 480 


Lys Gln Lys Lys Thr Arg Ser Lys Gly Arg Asn Glu Gln Phe Pro Val 
                485                 490                 495     


Leu Asp His Leu Leu Ser Ile Ile Lys Leu Pro Pro Asn Lys Asp Thr 
            500                 505                 510         


Thr Tyr Leu Ser Gln Ser Trp Ala Ala Leu Val Val Leu Pro His Ile 
        515                 520                 525             


Arg Pro Leu Glu Lys Glu Lys Val Ile Pro Leu Val Thr Gly Phe Ile 
    530                 535                 540                 


Glu Ala Leu Phe Met Thr Val Asp Lys Gly Ser Phe Gly Lys Gly Asn 
545                 550                 555                 560 


Leu Phe Val Leu Cys Gln Ala Val Asn Thr Leu Leu Ser Leu Glu Glu 
                565                 570                 575     


Ser Ser Glu Leu Leu His Leu Val Pro Val Glu Arg Val Lys Asn Leu 
            580                 585                 590         


Val Leu Thr Phe Pro Leu Glu Pro Ser Val Leu Leu Leu Thr Asp Leu 
        595                 600                 605             


Tyr Tyr Gln Arg Leu Ala Leu Cys Gly Cys Lys Gly Pro Leu Ser Gln 
    610                 615                 620                 


Glu Ala Leu Met Glu Leu Phe Pro Lys Leu Gln Ala Asn Ile Ser Thr 
625                 630                 635                 640 


Gly Val Ser Lys Ile Arg Leu Leu Thr Ile Arg Ile Leu Asn His Phe 
                645                 650                 655     


Asp Val Gln Leu Pro Glu Ser Met Glu Asp Asp Gly Leu Ser Glu Arg 
            660                 665                 670         


Gln Ser Val Phe Ala Ile Leu Arg Gln Ala Glu Leu Val Pro Ala Thr 
        675                 680                 685             


Val Asn Asp Tyr Arg Glu Lys Leu Leu His Leu Arg Lys Leu Arg His 
    690                 695                 700                 


Asp Val Val Gln Thr Ala Val Pro Asp Gly Pro Leu Gln Glu Val Pro 
705                 710                 715                 720 


Leu Arg Tyr Leu Leu Gly Met Leu Tyr Ile Asn Phe Ser Ala Leu Trp 
                725                 730                 735     


Asp Pro Val Ile Glu Leu Ile Ser Ser His Ala His Glu Met Glu Asn 
            740                 745                 750         


Lys Gln Phe Trp Lys Val Tyr Tyr Glu His Leu Glu Lys Ala Ala Thr 
        755                 760                 765             


His Ala Glu Lys Glu Leu Gln Asn Asp Met Thr Asp Glu Lys Ser Val 
    770                 775                 780                 


Gly Asp Glu Ser Trp Glu Gln Thr Gln Glu Gly Asp Val Gly Ala Leu 
785                 790                 795                 800 


Tyr His Glu Gln Leu Ala Leu Lys Thr Asp Cys Gln Glu Arg Leu Asp 
                805                 810                 815     


His Thr Asn Phe Arg Phe Leu Leu Trp Arg Ala Leu Thr Lys Phe Pro 
            820                 825                 830         


Glu Arg Val Glu Pro Arg Ser Arg Glu Leu Ser Pro Leu Phe Leu Arg 
        835                 840                 845             


Phe Ile Asn Asn Glu Tyr Tyr Pro Ala Asp Leu Gln Val Ala Pro Thr 
    850                 855                 860                 


Gln Asp Leu Arg Arg Lys Gly Lys Gly Met Val Ala Glu Glu Ile Glu 
865                 870                 875                 880 


Glu Glu Pro Ala Ala Gly Asp Asp Glu Glu Leu Glu Glu Glu Ala Val 
                885                 890                 895     


Pro Gln Asp Glu Ser Ser Gln Lys Lys Lys Thr Arg Arg Ala Ala Ala 
            900                 905                 910         


Lys Gln Leu Ile Ala His Leu Gln Val Phe Ser Lys Phe Ser Asn Pro 
        915                 920                 925             


Arg Ala Leu Tyr Leu Glu Ser Lys Leu Tyr Glu Leu Tyr Leu Gln Leu 
    930                 935                 940                 


Leu Leu His Gln Asp Gln Met Val Gln Lys Ile Thr Leu Asp Cys Ile 
945                 950                 955                 960 


Met Thr Tyr Lys His Pro His Val Leu Pro Tyr Arg Glu Asn Leu Gln 
                965                 970                 975     


Arg Leu Leu Glu Asp Arg Ser Phe Lys Glu Glu Ile Val His Phe Ser 
            980                 985                 990         


Ile Ser Glu Asp Asn Ala Val Val  Lys Thr Ala His Arg  Ala Asp Leu 
        995                 1000                 1005             


Phe Pro  Ile Leu Met Arg Ile  Leu Tyr Gly Arg Met  Lys Asn Lys 
    1010                 1015                 1020             


Thr Gly  Ser Lys Thr Gln Gly  Lys Ser Ala Ser Gly  Thr Arg Met 
    1025                 1030                 1035             


Ala Ile  Val Leu Arg Phe Leu  Ala Gly Thr Gln Pro  Glu Glu Ile 
    1040                 1045                 1050             


Gln Ile  Phe Leu Asp Leu Leu  Phe Glu Pro Val Arg  His Phe Lys 
    1055                 1060                 1065             


Asn Gly  Glu Cys His Ser Ala  Val Ile Gln Ala Val  Glu Asp Leu 
    1070                 1075                 1080             


Asp Leu  Ser Lys Val Leu Pro  Leu Gly Arg Gln His  Gly Ile Leu 
    1085                 1090                 1095             


Asn Ser  Leu Glu Ile Val Leu  Lys Asn Ile Ser His  Leu Ile Ser 
    1100                 1105                 1110             


Ala Tyr  Leu Pro Lys Ile Leu  Gln Ile Leu Leu Cys  Met Thr Ala 
    1115                 1120                 1125             


Thr Val  Ser His Ile Leu Asp  Gln Arg Glu Lys Ile  Gln Leu Arg 
    1130                 1135                 1140             


Phe Ile  Asn Pro Leu Lys Asn  Leu Arg Arg Leu Gly  Ile Lys Met 
    1145                 1150                 1155             


Val Thr  Asp Ile Phe Leu Asp  Trp Glu Ser Tyr Gln  Phe Arg Thr 
    1160                 1165                 1170             


Glu Glu  Ile Asp Ala Val Phe  His Gly Ala Val Trp  Pro Gln Ile 
    1175                 1180                 1185             


Ser Arg  Leu Gly Ser Glu Ser  Gln Tyr Ser Pro Thr  Pro Leu Leu 
    1190                 1195                 1200             


Lys Leu  Ile Ser Ile Trp Ser  Arg Asn Ala Arg Tyr  Phe Pro Leu 
    1205                 1210                 1215             


Leu Ala  Lys Gln Lys Pro Gly  His Pro Glu Cys Asp  Ile Leu Thr 
    1220                 1225                 1230             


Asn Val  Phe Ala Ile Leu Ser  Ala Lys Asn Leu Ser  Asp Ala Thr 
    1235                 1240                 1245             


Ala Ser  Ile Val Met Asp Ile  Val Asp Asp Leu Leu  Asn Leu Pro 
    1250                 1255                 1260             


Asp Phe  Glu Pro Thr Glu Thr  Val Leu Asn Leu Leu  Val Thr Gly 
    1265                 1270                 1275             


Cys Val  Tyr Pro Gly Ile Ala  Glu Asn Ile Gly Glu  Ser Ile Thr 
    1280                 1285                 1290             


Ile Gly  Gly Arg Leu Ile Leu  Pro His Val Pro Ala  Ile Leu Gln 
    1295                 1300                 1305             


Tyr Leu  Ser Lys Thr Thr Ile  Ser Ala Glu Lys Val  Lys Lys Lys 
    1310                 1315                 1320             


Lys Asn  Arg Ala Gln Val Ser  Lys Glu Leu Gly Ile  Leu Ser Lys 
    1325                 1330                 1335             


Ile Ser  Lys Phe Met Lys Asp  Lys Glu Gln Ser Ser  Val Leu Ile 
    1340                 1345                 1350             


Thr Leu  Leu Leu Pro Phe Leu  His Arg Gly Asn Ile  Ala Glu Asp 
    1355                 1360                 1365             


Thr Glu  Val Asp Ile Leu Val  Thr Val Gln Asn Leu  Leu Lys His 
    1370                 1375                 1380             


Cys Val  Asp Pro Thr Ser Phe  Leu Lys Pro Ile Ala  Lys Leu Phe 
    1385                 1390                 1395             


Ser Val  Ile Lys Asn Lys Leu  Ser Arg Lys Leu Leu  Cys Thr Val 
    1400                 1405                 1410             


Phe Glu  Thr Leu Ser Asp Phe  Glu Ser Gly Leu Lys  Tyr Ile Thr 
    1415                 1420                 1425             


Asp Val  Val Lys Leu Asn Ala  Phe Asp Gln Arg His  Leu Asp Asp 
    1430                 1435                 1440             


Ile Asn  Phe Asp Val Arg Phe  Glu Thr Phe Gln Thr  Ile Thr Ser 
    1445                 1450                 1455             


Tyr Ile  Lys Glu Met Gln Ile  Val Asp Val Asn Tyr  Leu Ile Pro 
    1460                 1465                 1470             


Val Met  His Asn Cys Phe Tyr  Asn Leu Glu Leu Gly  Asp Met Ser 
    1475                 1480                 1485             


Leu Ser  Asp Asn Ala Ser Met  Cys Leu Met Ser Ile  Ile Lys Lys 
    1490                 1495                 1500             


Leu Pro  Ala Leu Asn Val Thr  Glu Lys Asp Tyr Arg  Glu Ile Ile 
    1505                 1510                 1515             


His Arg  Ser Leu Leu Glu Lys  Leu Arg Lys Gly Leu  Lys Ser Gln 
    1520                 1525                 1530             


Thr Glu  Ser Ile Gln Gln Asp  Tyr Thr Thr Ile Leu  Ser Cys Leu 
    1535                 1540                 1545             


Ile Gln  Thr Phe Pro Asn Gln  Leu Glu Phe Lys Asp  Leu Val Gln 
    1550                 1555                 1560             


Leu Thr  His Tyr His Asp Pro  Glu Met Asp Phe Phe  Glu Asn Met 
    1565                 1570                 1575             


Lys His  Ile Gln Ile His Arg  Arg Ala Arg Ala Leu  Lys Lys Leu 
    1580                 1585                 1590             


Ala Lys  Gln Leu Met Glu Gly  Lys Val Val Leu Ser  Ser Lys Ser 
    1595                 1600                 1605             


Leu Gln  Asn Tyr Ile Met Pro  Tyr Ala Met Thr Pro  Ile Phe Asp 
    1610                 1615                 1620             


Glu Lys  Met Leu Lys His Glu  Asn Ile Thr Thr Ala  Ala Thr Glu 
    1625                 1630                 1635             


Ile Ile  Gly Ala Ile Cys Lys  His Leu Ser Trp Ser  Ala Tyr Met 
    1640                 1645                 1650             


Tyr Tyr  Leu Lys His Phe Ile  His Val Leu Gln Thr  Gly Gln Ile 
    1655                 1660                 1665             


Asn Gln  Lys Leu Gly Val Ser  Leu Leu Val Ile Val  Leu Glu Ala 
    1670                 1675                 1680             


Phe His  Phe Asp His Lys Thr  Leu Glu Glu Gln Met  Gly Lys Ile 
    1685                 1690                 1695             


Glu Asn  Glu Glu Asn Ala Ile  Glu Ala Ile Glu Leu  Pro Glu Pro 
    1700                 1705                 1710             


Glu Ala  Met Glu Leu Glu Arg  Val Asp Glu Glu Glu  Lys Glu Tyr 
    1715                 1720                 1725             


Thr Cys  Lys Ser Leu Ser Asp  Asn Gly Gln Pro Gly  Thr Pro Asp 
    1730                 1735                 1740             


Pro Ala  Asp Ser Gly Gly Thr  Ser Ala Lys Glu Ser  Glu Cys Ile 
    1745                 1750                 1755             


Thr Lys  Pro Val Ser Phe Leu  Pro Gln Asn Lys Glu  Glu Ile Glu 
    1760                 1765                 1770             


Arg Thr  Ile Lys Asn Ile Gln  Gly Thr Ile Thr Gly  Asp Ile Leu 
    1775                 1780                 1785             


Pro Arg  Leu His Lys Cys Leu  Ala Ser Thr Thr Lys  Arg Glu Glu 
    1790                 1795                 1800             


Glu His  Lys Leu Val Lys Ser  Lys Val Val Asn Asp  Glu Glu Val 
    1805                 1810                 1815             


Val Arg  Val Pro Leu Ala Phe  Ala Met Val Lys Leu  Met Gln Ser 
    1820                 1825                 1830             


Leu Pro  Gln Glu Val Met Glu  Ala Asn Leu Pro Ser  Ile Leu Leu 
    1835                 1840                 1845             


Lys Val  Cys Ala Leu Leu Lys  Asn Arg Ala Gln Glu  Ile Arg Asp 
    1850                 1855                 1860             


Ile Ala  Arg Ser Thr Leu Ala  Lys Ile Ile Glu Asp  Leu Gly Val 
    1865                 1870                 1875             


His Phe  Leu Gln Tyr Val Leu  Lys Glu Leu Gln Thr  Thr Leu Val 
    1880                 1885                 1890             


Arg Gly  Tyr Gln Val His Val  Leu Thr Phe Thr Val  His Met Leu 
    1895                 1900                 1905             


Leu Gln  Gly Leu Thr Asn Lys  Leu Gln Val Gly Asp  Leu Asp Ser 
    1910                 1915                 1920             


Cys Leu  Asp Ile Met Ile Glu  Ile Phe Asn His Glu  Leu Phe Gly 
    1925                 1930                 1935             


Ala Val  Ala Glu Glu Lys Glu  Val Lys Gln Ile Leu  Ser Lys Val 
    1940                 1945                 1950             


Met Glu  Ala Arg Arg Ser Lys  Ser Tyr Asp Ser Tyr  Glu Ile Leu 
    1955                 1960                 1965             


Gly Lys  Phe Val Gly Lys Asp  Gln Val Thr Lys Leu  Ile Leu Pro 
    1970                 1975                 1980             


Leu Lys  Glu Ile Leu Gln Asn  Thr Thr Ser Leu Lys  Leu Ala Arg 
    1985                 1990                 1995             


Lys Val  His Glu Thr Leu Arg  Arg Ile Thr Val Gly  Leu Ile Val 
    2000                 2005                 2010             


Asn Gln  Glu Met Thr Ala Glu  Ser Ile Leu Leu Leu  Ser Tyr Gly 
    2015                 2020                 2025             


Leu Ile  Ser Glu Asn Leu Pro  Leu Leu Thr Glu Lys  Glu Lys Asn 
    2030                 2035                 2040             


Pro Val  Ala Pro Ala Pro Asp  Pro Arg Leu Pro Pro  Gln Ser Cys 
    2045                 2050                 2055             


Leu Leu  Leu Pro Pro Thr Pro  Val Arg Gly Gly Gln  Lys Ala Val 
    2060                 2065                 2070             


Val Ser  Arg Lys Thr Asn Met  His Ile Phe Ile Glu  Ser Gly Leu 
    2075                 2080                 2085             


Arg Leu  Leu His Leu Ser Leu  Lys Thr Ser Lys Ile  Lys Ser Ser 
    2090                 2095                 2100             


Gly Glu  Cys Val Leu Glu Met  Leu Asp Pro Phe Val  Ser Leu Leu 
    2105                 2110                 2115             


Ile Asp  Cys Leu Gly Ser Met  Asp Val Lys Val Ile  Thr Gly Ala 
    2120                 2125                 2130             


Leu Gln  Cys Leu Ile Trp Val  Leu Arg Phe Pro Leu  Pro Ser Ile 
    2135                 2140                 2145             


Glu Thr  Lys Ala Glu Gln Leu  Thr Lys His Leu Phe  Leu Leu Leu 
    2150                 2155                 2160             


Lys Asp  Tyr Ala Lys Leu Gly  Ala Ala Arg Gly Gln  Asn Phe His 
    2165                 2170                 2175             


Leu Val  Val Asn Cys Phe Lys  Cys Val Thr Ile Leu  Val Lys Lys 
    2180                 2185                 2190             


Val Lys  Ser Tyr Gln Ile Thr  Glu Lys Gln Leu Gln  Val Leu Leu 
    2195                 2200                 2205             


Ala Tyr  Ala Glu Glu Asp Ile  Tyr Asp Thr Ser Arg  Gln Ala Thr 
    2210                 2215                 2220             


Ala Phe  Gly Leu Leu Lys Ala  Ile Leu Ser Arg Lys  Leu Leu Val 
    2225                 2230                 2235             


Pro Glu  Ile Asp Glu Val Met  Arg Lys Val Ser Lys  Leu Ala Val 
    2240                 2245                 2250             


Ser Ala  Gln Ser Glu Pro Ala  Arg Val Gln Cys Arg  Gln Val Phe 
    2255                 2260                 2265             


Leu Lys  Tyr Ile Leu Asp Tyr  Pro Leu Gly Asp Lys  Leu Arg Pro 
    2270                 2275                 2280             


Asn Leu  Glu Phe Met Leu Ala  Gln Leu Asn Tyr Glu  His Glu Thr 
    2285                 2290                 2295             


Gly Arg  Glu Ser Thr Leu Glu  Met Ile Ala Tyr Leu  Phe Asp Thr 
    2300                 2305                 2310             


Phe Pro  Gln Gly Leu Leu His  Glu Asn Cys Gly Met  Phe Phe Ile 
    2315                 2320                 2325             


Pro Leu  Cys Leu Met Thr Ile  Asn Asp Asp Ser Ala  Thr Cys Lys 
    2330                 2335                 2340             


Lys Met  Ala Ser Met Thr Ile  Lys Ser Leu Leu Gly  Lys Ile Ser 
    2345                 2350                 2355             


Leu Glu  Lys Lys Asp Trp Leu  Phe Asp Met Val Thr  Thr Trp Phe 
    2360                 2365                 2370             


Gly Ala  Lys Lys Arg Leu Asn  Arg Gln Leu Ala Ala  Leu Ile Cys 
    2375                 2380                 2385             


Gly Leu  Phe Val Glu Ser Glu  Gly Val Asp Phe Glu  Lys Arg Leu 
    2390                 2395                 2400             


Gly Thr  Val Leu Pro Val Ile  Glu Lys Glu Ile Asp  Pro Glu Asn 
    2405                 2410                 2415             


Phe Lys  Asp Ile Met Glu Glu  Thr Glu Glu Lys Ala  Ala Asp Arg 
    2420                 2425                 2430             


Leu Leu  Phe Ser Phe Leu Thr  Leu Ile Thr Lys Leu  Ile Lys Glu 
    2435                 2440                 2445             


Cys Asn  Ile Ile Gln Phe Thr  Lys Pro Ala Glu Thr  Leu Ser Lys 
    2450                 2455                 2460             


Ile Trp  Ser His Val His Ser  His Leu Arg His Pro  His Asn Trp 
    2465                 2470                 2475             


Val Trp  Leu Thr Ala Ala Gln  Ile Phe Gly Leu Leu  Phe Ala Ser 
    2480                 2485                 2490             


Cys Gln  Pro Glu Glu Leu Ile  Gln Lys Trp Asn Thr  Lys Lys Thr 
    2495                 2500                 2505             


Lys Lys  His Leu Pro Glu Pro  Val Ala Ile Lys Phe  Leu Ala Ser 
    2510                 2515                 2520             


Asp Leu  Asp Gln Lys Met Lys  Ser Ile Ser Leu Ala  Ser Cys His 
    2525                 2530                 2535             


Gln Leu  His Ser Lys Phe Leu  Asp Gln Ser Leu Gly  Glu Gln Val 
    2540                 2545                 2550             


Val Lys  Asn Leu Leu Phe Ala  Ala Lys Val Leu Tyr  Leu Leu Glu 
    2555                 2560                 2565             


Leu Tyr  Cys Glu Asp Lys Gln  Ser Lys Ile Lys Glu  Asp Leu Glu 
    2570                 2575                 2580             


Glu Gln  Glu Ala Leu Glu Asp  Gly Val Ala Cys Ala  Asp Glu Lys 
    2585                 2590                 2595             


Ala Glu  Ser Asp Gly Glu Glu  Lys Glu Glu Val Lys  Glu Glu Leu 
    2600                 2605                 2610             


Gly Arg  Pro Ala Thr Leu Leu  Trp Leu Ile Gln Lys  Leu Ser Arg 
    2615                 2620                 2625             


Ile Ala  Lys Leu Glu Ala Ala  Tyr Ser Pro Arg Asn  Pro Leu Lys 
    2630                 2635                 2640             


Arg Thr  Cys Ile Phe Lys Phe  Leu Gly Ala Val Ala  Met Asp Leu 
    2645                 2650                 2655             


Gly Ile  Asp Lys Val Lys Pro  Tyr Leu Pro Met Ile  Ile Ala Pro 
    2660                 2665                 2670             


Leu Phe  Arg Glu Leu Asn Ser  Thr Tyr Ser Glu Gln  Asp Pro Leu 
    2675                 2680                 2685             


Leu Lys  Asn Leu Ser Gln Glu  Ile Ile Glu Leu Leu  Lys Lys Leu 
    2690                 2695                 2700             


Val Gly  Leu Glu Ser Phe Ser  Leu Ala Phe Ala Ser  Val Gln Lys 
    2705                 2710                 2715             


Gln Ala  Asn Glu Lys Arg Ala  Leu Arg Lys Lys Arg  Lys Ala Leu 
    2720                 2725                 2730             


Glu Phe  Val Thr Asn Pro Asp  Ile Ala Ala Lys Lys  Lys Met Lys 
    2735                 2740                 2745             


Lys His  Lys Asn Lys Ser Glu  Ala Lys Lys Arg Lys  Ile Glu Phe 
    2750                 2755                 2760             


Leu Arg  Pro Gly Tyr Lys Ala  Lys Arg Gln Lys Ser  His Ser Leu 
    2765                 2770                 2775             


Lys Asp  Leu Ala Met Val Glu  
    2780                 2785 


<210>  3006
<211>  1575
<212>  DNA
<213>  Homosapiens

<400>  3006
tcccttctga ggaaacgaaa ccaacagcag tccaagctca gtcagcagaa gagataaaag     60

caaacaggtc tgggaggcag ttctgttgcc actctctctc ctgtcaatga tggatctcag    120

aaatacccca gccaaatctc tggacaagtt cattgaagac tatctcttgc cagacacgtg    180

tttccgcatg caaatcaacc atgccattga catcatctgt gggttcctga aggaaaggtg    240

cttccgaggt agctcctacc ctgtgtgtgt gtccaaggtg gtaaagggtg gctcctcagg    300

caagggcacc accctcagag gccgatctga cgctgacctg gttgtcttcc tcagtcctct    360

caccactttt caggatcagt taaatcgccg gggagagttc atccaggaaa ttaggagaca    420

gctggaagcc tgtcaaagag agagagcatt ttccgtgaag tttgaggtcc aggctccacg    480

ctggggcaac ccccgtgcgc tcagcttcgt actgagttcg ctccagctcg gggagggggt    540

ggagttcgat gtgctgcctg cctttgatgc cctgggtcag ttgactggcg gctataaacc    600

taacccccaa atctatgtca agctcatcga ggagtgcacc gacctgcaga aagagggcga    660

gttctccacc tgcttcacag aactacagag agacttcctg aagcagcgcc ccaccaagct    720

caagagcctc atccgcctag tcaagcactg gtaccaaaat tgtaagaaga agcttgggaa    780

gctgccacct cagtatgccc tggagctcct gacggtctat gcttgggagc gagggagcat    840

gaaaacacat ttcaacacag cccagggatt tcggacggtc ttggaattag tcataaacta    900

ccagcaactc tgcatctact ggacaaagta ttatgacttt aaaaacccca ttattgaaaa    960

gtacctgaga aggcagctca cgaaacccag gcctgtgatc ctggacccgg cggaccctac   1020

aggaaacttg ggtggtggag acccaaaggg ttggaggcag ctggcacaag aggctgaggc   1080

ctggctgaat tacccatgct ttaagaattg ggatgggtcc ccagtgagct cctggattct   1140

gctgacccag cacactccag gcagcatcca ccccacaggc agaagaggac tggacctgca   1200

ccatcctctg aatgccagtg catcttgggg gaaagggctc cagtgttatc tggaccagtt   1260

ccttcatttt caggtgggac tcttgatcca gagaggacaa agctcctcag tgagctggtg   1320

tataatccag gacagaaccc aggtctcctg actcctggcc ttctatgccc tctatcctat   1380

catagataac attctccaca gcctcacttc attccaccta ttctctgaaa atattccctg   1440

agagagaaca gagagattta gataagagaa tgaaattcca gccttgactt tcttctgtgc   1500

acctgatggg agggtaatgt ctaatgtatt atcaataaca ataaaaataa agcaaatacc   1560

atttaaaaaa aaaaa                                                    1575


<210>  3007
<211>  414
<212>  PRT
<213>  Homosapiens

<400>  3007

Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile 
1               5                   10                  15      


Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His 
            20                  25                  30          


Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly 
        35                  40                  45              


Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser 
    50                  55                  60                  


Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val 
65                  70                  75                  80  


Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly 
                85                  90                  95      


Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu 
            100                 105                 110         


Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn 
        115                 120                 125             


Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly 
    130                 135                 140                 


Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr 
145                 150                 155                 160 


Gly Gly Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu 
                165                 170                 175     


Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu 
            180                 185                 190         


Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu 
        195                 200                 205             


Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly 
    210                 215                 220                 


Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp 
225                 230                 235                 240 


Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg 
                245                 250                 255     


Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp 
            260                 265                 270         


Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg 
        275                 280                 285             


Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro 
    290                 295                 300                 


Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala 
305                 310                 315                 320 


Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp 
                325                 330                 335     


Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Thr Gln His Thr Pro Gly 
            340                 345                 350         


Ser Ile His Pro Thr Gly Arg Arg Gly Leu Asp Leu His His Pro Leu 
        355                 360                 365             


Asn Ala Ser Ala Ser Trp Gly Lys Gly Leu Gln Cys Tyr Leu Asp Gln 
    370                 375                 380                 


Phe Leu His Phe Gln Val Gly Leu Leu Ile Gln Arg Gly Gln Ser Ser 
385                 390                 395                 400 


Ser Val Ser Trp Cys Ile Ile Gln Asp Arg Thr Gln Val Ser 
                405                 410                 


<210>  3008
<211>  1470
<212>  DNA
<213>  Homosapiens

<400>  3008
tcccttctga ggaaacgaaa ccaacagcag tccaagctca gtcagcagaa gagataaaag     60

caaacaggtc tgggaggcag ttctgttgcc actctctctc ctgtcaatga tggatctcag    120

aaatacccca gccaaatctc tggacaagtt cattgaagac tatctcttgc cagacacgtg    180

tttccgcatg caaatcaacc atgccattga catcatctgt gggttcctga aggaaaggtg    240

cttccgaggt agctcctacc ctgtgtgtgt gtccaaggtg gtaaagggtg gctcctcagg    300

caagggcacc accctcagag gccgatctga cgctgacctg gttgtcttcc tcagtcctct    360

caccactttt caggatcagt taaatcgccg gggagagttc atccaggaaa ttaggagaca    420

gctggaagcc tgtcaaagag agagagcatt ttccgtgaag tttgaggtcc aggctccacg    480

ctggggcaac ccccgtgcgc tcagcttcgt actgagttcg ctccagctcg gggagggggt    540

ggagttcgat gtgctgcctg cctttgatgc cctgggtcag ttgactggcg gctataaacc    600

taacccccaa atctatgtca agctcatcga ggagtgcacc gacctgcaga aagagggcga    660

gttctccacc tgcttcacag aactacagag agacttcctg aagcagcgcc ccaccaagct    720

caagagcctc atccgcctag tcaagcactg gtaccaaaat tgtaagaaga agcttgggaa    780

gctgccacct cagtatgccc tggagctcct gacggtctat gcttgggagc gagggagcat    840

gaaaacacat ttcaacacag cccagggatt tcggacggtc ttggaattag tcataaacta    900

ccagcaactc tgcatctact ggacaaagta ttatgacttt aaaaacccca ttattgaaaa    960

gtacctgaga aggcagctca cgaaacccag gcctgtgatc ctggacccgg cggaccctac   1020

aggaaacttg ggtggtggag acccaaaggg ttggaggcag ctggcacaag aggctgaggc   1080

ctggctgaat tacccatgct ttaagaattg ggatgggtcc ccagtgagct cctggattct   1140

gctggtgaga cctcctgctt cctccctgcc attcatccct gcccctctcc atgaagcttg   1200

agacatatag ctggagacca ttctttccaa agaacttacc tcttgccaaa ggccatttat   1260

attcatatag tgacaggctg tgctccatat tttacagtca ttttggtcac aatcgagggt   1320

ttctggaatt ttcacatccc ttgtccagaa ttcattcccc taagagtaat aataaataat   1380

ctctaacacc atttattgac tgtctgcttc gggctcaggt tctgtcctaa gccctttaat   1440

atgcactctc tcattaaata gtcacaacaa                                    1470


<210>  3009
<211>  364
<212>  PRT
<213>  Homosapiens

<400>  3009

Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile 
1               5                   10                  15      


Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His 
            20                  25                  30          


Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly 
        35                  40                  45              


Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser 
    50                  55                  60                  


Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val 
65                  70                  75                  80  


Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly 
                85                  90                  95      


Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu 
            100                 105                 110         


Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn 
        115                 120                 125             


Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly 
    130                 135                 140                 


Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr 
145                 150                 155                 160 


Gly Gly Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu 
                165                 170                 175     


Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu 
            180                 185                 190         


Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu 
        195                 200                 205             


Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly 
    210                 215                 220                 


Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp 
225                 230                 235                 240 


Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg 
                245                 250                 255     


Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp 
            260                 265                 270         


Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg 
        275                 280                 285             


Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro 
    290                 295                 300                 


Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala 
305                 310                 315                 320 


Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp 
                325                 330                 335     


Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Val Arg Pro Pro Ala Ser 
            340                 345                 350         


Ser Leu Pro Phe Ile Pro Ala Pro Leu His Glu Ala 
        355                 360                 


<210>  3010
<211>  1673
<212>  DNA
<213>  Homosapiens

<400>  3010
tcccttctga ggaaacgaaa ccaacagcag tccaagctca gtcagcagaa gagataaaag     60

caaacaggtc tgggaggcag ttctgttgcc actctctctc ctgtcaatga tggatctcag    120

aaatacccca gccaaatctc tggacaagtt cattgaagac tatctcttgc cagacacgtg    180

tttccgcatg caaatcaacc atgccattga catcatctgt gggttcctga aggaaaggtg    240

cttccgaggt agctcctacc ctgtgtgtgt gtccaaggtg gtaaagggtg gctcctcagg    300

caagggcacc accctcagag gccgatctga cgctgacctg gttgtcttcc tcagtcctct    360

caccactttt caggatcagt taaatcgccg gggagagttc atccaggaaa ttaggagaca    420

gctggaagcc tgtcaaagag agagagcatt ttccgtgaag tttgaggtcc aggctccacg    480

ctggggcaac ccccgtgcgc tcagcttcgt actgagttcg ctccagctcg gggagggggt    540

ggagttcgat gtgctgcctg cctttgatgc cctgggtcag ttgactggcg gctataaacc    600

taacccccaa atctatgtca agctcatcga ggagtgcacc gacctgcaga aagagggcga    660

gttctccacc tgcttcacag aactacagag agacttcctg aagcagcgcc ccaccaagct    720

caagagcctc atccgcctag tcaagcactg gtaccaaaat tgtaagaaga agcttgggaa    780

gctgccacct cagtatgccc tggagctcct gacggtctat gcttgggagc gagggagcat    840

gaaaacacat ttcaacacag cccagggatt tcggacggtc ttggaattag tcataaacta    900

ccagcaactc tgcatctact ggacaaagta ttatgacttt aaaaacccca ttattgaaaa    960

gtacctgaga aggcagctca cgaaacccag gcctgtgatc ctggacccgg cggaccctac   1020

aggaaacttg ggtggtggag acccaaaggg ttggaggcag ctggcacaag aggctgaggc   1080

ctggctgaat tacccatgct ttaagaattg ggatgggtcc ccagtgagct cctggattct   1140

gctggctgaa agcaacagtg cagacgatga gaccgacgat cccaggaggt atcagaaata   1200

tggttacatt ggaacacatg agtaccctca tttctctcat agacccagca cactccaggc   1260

agcatccacc ccacaggcag aagaggactg gacctgcacc atcctctgaa tgccagtgca   1320

tcttggggga aagggctcca gtgttatctg gaccagttcc ttcattttca ggtgggactc   1380

ttgatccaga gaggacaaag ctcctcagtg agctggtgta taatccagga cagaacccag   1440

gtctcctgac tcctggcctt ctatgccctc tatcctatca tagataacat tctccacagc   1500

ctcacttcat tccacctatt ctctgaaaat attccctgag agagaacaga gagatttaga   1560

taagagaatg aaattccagc cttgactttc ttctgtgcac ctgatgggag ggtaatgtct   1620

aatgtattat caataacaat aaaaataaag caaataccat ttaaaaaaaa aaa          1673


<210>  3011
<211>  400
<212>  PRT
<213>  Homosapiens

<400>  3011

Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile 
1               5                   10                  15      


Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His 
            20                  25                  30          


Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly 
        35                  40                  45              


Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser 
    50                  55                  60                  


Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val 
65                  70                  75                  80  


Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly 
                85                  90                  95      


Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu 
            100                 105                 110         


Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn 
        115                 120                 125             


Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly 
    130                 135                 140                 


Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr 
145                 150                 155                 160 


Gly Gly Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu 
                165                 170                 175     


Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu 
            180                 185                 190         


Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu 
        195                 200                 205             


Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly 
    210                 215                 220                 


Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp 
225                 230                 235                 240 


Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg 
                245                 250                 255     


Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp 
            260                 265                 270         


Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg 
        275                 280                 285             


Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro 
    290                 295                 300                 


Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala 
305                 310                 315                 320 


Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp 
                325                 330                 335     


Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Ala Glu Ser Asn Ser Ala 
            340                 345                 350         


Asp Asp Glu Thr Asp Asp Pro Arg Arg Tyr Gln Lys Tyr Gly Tyr Ile 
        355                 360                 365             


Gly Thr His Glu Tyr Pro His Phe Ser His Arg Pro Ser Thr Leu Gln 
    370                 375                 380                 


Ala Ala Ser Thr Pro Gln Ala Glu Glu Asp Trp Thr Cys Thr Ile Leu 
385                 390                 395                 400 


<210>  3012
<211>  6646
<212>  DNA
<213>  Homosapiens

<400>  3012
gttcggagag ccgggcggga aaacgaaacc agaaatccga aggccgcgcc agagccctgc     60

ttccccttgc acctgcgccg ggcggccatg gacttgtaca gcaccccggc cgctgcgctg    120

gacaggttcg tggccagaag gctgcagccg cggaaggagt tcgtagagaa ggcgcggcgc    180

gctctgggcg ccctggccgc tgccctgagg gagcgcgggg gccgcctcgg tgctgctgcc    240

ccgcgggtgc tgaaaactgt caagggaggc tcctcgggcc ggggcacagc tctcaagggt    300

ggctgtgatt ctgaacttgt catcttcctc gactgcttca agagctatgt ggaccagagg    360

gcccgccgtg cagagatcct cagtgagatg cgggcatcgc tggaatcctg gtggcagaac    420

ccagtccctg gtctgagact cacgtttcct gagcagagcg tgcctggggc cctgcagttc    480

cgcctgacat ccgtagatct tgaggactgg atggatgtta gcctggtgcc tgccttcaat    540

gtcctgggtc aggccggctc cggcgtcaaa cccaagccac aagtctactc taccctcctc    600

aacagtggct gccaaggggg cgagcatgcg gcctgcttca cagagctgcg gaggaacttt    660

gtgaacattc gcccagccaa gttgaagaac ctaatcttgc tggtgaagca ctggtaccac    720

caggtgtgcc tacaggggtt gtggaaggag acgctgcccc cggtctatgc cctggaattg    780

ctgaccatct tcgcctggga gcagggctgt aagaaggatg ctttcagcct agccgaaggc    840

ctccgaactg tcctgggcct gatccaacag catcagcacc tgtgtgtttt ctggactgtc    900

aactatggct tcgaggaccc tgcagttggg cagttcttgc agcggcagct taagagaccc    960

aggcctgtga tcctggaccc agctgacccc acatgggacc tggggaatgg ggcagcctgg   1020

cactgggatt tgctagccca ggaggcagca tcctgctatg accacccatg ctttctgagg   1080

gggatggggg acccagtgca gtcttggaag gggccgggcc ttccacgtgc tggatgctca   1140

ggtttgggcc accccatcca gctagaccct aaccagaaga cccctgaaaa cagcaagagc   1200

ctcaatgctg tgtacccaag agcagggagc aaacctccct catgcccagc tcctggcccc   1260

actggggcag ccagcatcgt cccctctgtg ccgggaatgg ccttggacct gtctcagatc   1320

cccaccaagg agctggaccg cttcatccag gaccacctga agccgagccc ccagttccag   1380

gagcaggtga aaaaggccat cgacatcatc ttgcgctgcc tccatgagaa ctgtgttcac   1440

aaggcctcaa gagtcagtaa agggggctca tttggccggg gcacagacct aagggatggc   1500

tgtgatgttg aactcatcat cttcctcaac tgcttcacgg actacaagga ccaggggccc   1560

cgccgcgcag agatccttga tgagatgcga gcgcagctag aatcctggtg gcaggaccag   1620

gtgcccagcc tgagccttca gtttcctgag cagaatgtgc ctgaggctct gcagttccag   1680

ctggtgtcca cagccctgaa gagctggacg gatgttagcc tgctgcctgc cttcgatgct   1740

gtggggcagc tcagttctgg caccaaacca aatccccagg tctactcgag gctcctcacc   1800

agtggctgcc aggagggcga gcataaggcc tgcttcgcag agctgcggag gaacttcatg   1860

aacattcgcc ctgtcaagct gaagaacctg attctgctgg tgaagcactg gtaccgccag   1920

gttgcggctc agaacaaagg aaaaggacca gcccctgcct ctctgccccc agcctatgcc   1980

ctggagctcc tcaccatctt tgcctgggag cagggctgca ggcaggattg tttcaacatg   2040

gcccaaggct tccggacggt gctggggctc gtgcaacagc atcagcagct ctgtgtctac   2100

tggacggtca actatagcac tgaggaccca gccatgagaa tgcaccttct tggccagctt   2160

cgaaaaccca gacccctggt cctggacccc gctgatccca cctggaacgt gggccacggt   2220

agctgggagc tgttggccca ggaagcagca gcgctgggga tgcaggcctg ctttctgagt   2280

agagacggga catctgtgca gccctgggat gtgatgccag ccctccttta ccaaacccca   2340

gctggggacc ttgacaagtt catcagtgaa tttctccagc ccaaccgcca gttcctggcc   2400

caggtgaaca aggccgttga taccatctgt tcatttttga aggaaaactg cttccggaat   2460

tctcccatca aagtgatcaa ggtggtcaag ggtggctctt cagccaaagg cacagctctg   2520

cgaggccgct cagatgccga cctcgtggtg ttcctcagct gcttcagcca gttcactgag   2580

cagggcaaca agcgggccga gatcatctcc gagatccgag cccagctgga ggcatgtcaa   2640

caggagcggc agttcgaggt caagtttgaa gtctccaaat gggagaatcc ccgcgtgctg   2700

agcttctcac tgacatccca gacgatgctg gaccagagtg tggactttga tgtgctgcca   2760

gcctttgacg ccctaggcca gctggtctct ggctccaggc ccagctctca agtctacgtc   2820

gacctcatcc acagctacag caatgcgggc gagtactcca cctgcttcac agagctacaa   2880

cgggacttca tcatctctcg ccctaccaag ctgaagagcc tgatccggct ggtgaagcac   2940

tggtaccagc agtgtaccaa gatctccaag gggagaggct ccctaccccc acagcacggg   3000

ctggaactcc tgactgtgta tgcctgggag cagggcggga aggactccca gttcaacatg   3060

gctgagggct tccgcacggt cctggagctg gtcacccagt accgccagct ctgtatctac   3120

tggaccatca actacaacgc caaggacaag actgttggag acttcctgaa acagcagctt   3180

cagaagccca ggcctatcat cctggatccg gctgacccga caggcaacct gggccacaat   3240

gcccgctggg acctgctggc caaggaagct gcagcctgca catctgccct gtgctgcatg   3300

ggacggaatg gcatccccat ccagccatgg ccagtgaagg ctgctgtgtg aagttgagaa   3360

aatcagcggt cctactggat gaagagaaga tggacaccag ccctcagcat gaggaaattc   3420

agggtcccct accagatgag agagattgtg tacatgtgtg tgtgagcaca tgtgtgcatg   3480

tgtgtgcaca cgtgtgcatg tgtgtgtttt agtgaatctg ctctcccagc tcacacactc   3540

ccctgcctcc catggcttac acactaggat ccagactcca tggtttgaca ccagcctgcg   3600

tttgcagctt ctctgtcact tccatgactc tatcctcata ccaccactgc tgcttcccac   3660

ccagctgaga atgccccctc ctccctgact cctctctgcc catgcaaatt agctcacatc   3720

tttcctcctg ctgcaatcca tcccttcctc ccattggcct ctccttgcca aatctaaata   3780

gtttatatag ggatggcaga gagttcccat ctcatctgtc agccacagtc atttggtact   3840

ggctacctgg agccttatct tctgaagggt tttaaagaat ggccaattag ctgagaagaa   3900

ttatctaatc aattagtgat gtctgccatg gatgcagtag aggaaagtgg tggtacaagt   3960

gccatgattg attagcaatg tctgcactgg atacggaaaa aagaaggtgc ttgcaggttt   4020

acagtgtata tgtgggctat tgaagagccc tctgagctcg gttgctagca ggagagcatg   4080

cccatattgg cttactttgt ctgccacaga cacagacaga gggagttggg acatgcatgc   4140

tatggggacc ctcttgttgg acacctaatt ggatgcctct tcatgagagg cctccttttc   4200

ttcacctttt atgctgcact cctcccctag tttacacatc ttgatgctgt ggctcagttt   4260

gccttcctga atttttattg ggtccctgtt ttctctccta acatgctgag attctgcatc   4320

cccacagcct aaactgagcc agtggccaaa caaccgtgct cagcctgttt ctctctgccc   4380

tctagagcaa ggcccaccag gtccatccag gaggctctcc tgacctcaag tccaacaaca   4440

gtgtccacac tagtcaaggt tcagcccaga aaacagaaag cactctagga atcttaggca   4500

gaaagggatt ttatctaaat cactggaaag gctggaggag cagaaggcag aggccaccac   4560

tggactattg gtttcaatat tagaccactg tagccgaatc agaggccaga gagcagccac   4620

tgctactgct aatgccacca ctacccctgc catcactgcc ccacatggac aaaactggag   4680

tcgagaccta ggttagattc ctgcaaccac aaacatccat cagggatggc cagctgccag   4740

agctgcggga agacggatcc cacctccctt tcttagcaga atctaaatta cagccagacc   4800

tctggctgca gaggagtctg agacatgtat gattgaatgg gtgccaagtg ccagggggcg   4860

gagtccccag cagatgcatc ctggccatct gttgcgtgga tgagggagtg ggtctatctc   4920

agaggaagga acaggaaaca aagaaaggaa gccactgaac atcccttctc tgctccacag   4980

gagtgcctta gacagcctga ctctccacaa accactgtta aaacttacct gctaggaatg   5040

ctagattgaa tgggatggga agagccttcc ctcattattg tcattcttgg agagaggtga   5100

gcaaccaagg gaagctcctc tgattcacct agaacctgtt ctctgccgtc tttggctcag   5160

cctacagaga ctagagtagg tgaagggaca gaggacaggg cttctaatac ctgtgccata   5220

ttgacagcct ccatccctgt cccccatctt ggtgctgaac caacgctaag ggcaccttct   5280

tagactcacc tcatcgatac tgcctggtaa tccaaagcta gaactctcag gaccccaaac   5340

tccacctctt ggattggccc tggctgctgc cacacacata tccaagagct cagggccagt   5400

tctggtgggc agcagagacc tgctctgcca agttgtccag cagcagagtg gccctggcct   5460

gggcatcaca agccagtgat gctcctggga agaccaggtg gcaggtcgca gttgggtacc   5520

ttccattccc accacacaga ctctgggcct ccccgcaaaa tggctccaga attagagtaa   5580

ttatgagatg gtgggaacca gagcaactca ggtgcatgat acaaggagag gttgtcatct   5640

gggtagggca gagaggaggg cttgctcatc tgaacagggg tgtatttcat tccaggccct   5700

cagtctttgg caatggccac cctggtgttg gcatattggc cccactgtaa cttttggggg   5760

cttcccggtc tagccacacc ctcggatgga aagacttgac tgcataaaga tgtcagttct   5820

ccctgagttg attgataggc ttaatggtca ccctaaaaac acccacatat gcttttcgat   5880

ggaaccaggt aagttgacgc taaagttctt atggaaaaat acacacgcaa tagctaggaa   5940

aacacaggga aagaagagtt ctgagcaggg cctagtctta gccaatatta aaacatacta   6000

tgaagcctct gatacttaaa cagcatggcg ctggtacgta aatagaccaa tgcagttagg   6060

tggctctttc caagactctg gggaaaaaag tagtaaaaag ctaaatgcaa tcaatcagca   6120

attgaaagct aagtgagaga gccagagggc ctccttggtg gtaaaagagg gttgcatttc   6180

ttgcagccag aaggcagaga aagtgaagac caagtccaga actgaatcct aagaaatgca   6240

ggactgcaaa gaaattggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tttaattttt   6300

aaaaagtttt tattgagata caagtcaata ccataaagct ctcacccttc taaagtgtac   6360

aattcagtgg tgtgagtata ttcataagat ttatacttgg tgtctattca taagacttat   6420

atccagcata ttcataacta gagccatatc acagatgcat tcatcataat aattccagac   6480

attttcatca ccctaaaagg aaaccctgaa acccattagc agtcattccc cattcctcca   6540

acccattctc tccctaatcc ctagaaacca ccaatctgct gtgtatttca tctattgcca   6600

acatttcata taaatggcat catacaaaaa aaaaaaaaaa aaaaaa                  6646


<210>  3013
<211>  1087
<212>  PRT
<213>  Homosapiens

<400>  3013

Met Asp Leu Tyr Ser Thr Pro Ala Ala Ala Leu Asp Arg Phe Val Ala 
1               5                   10                  15      


Arg Arg Leu Gln Pro Arg Lys Glu Phe Val Glu Lys Ala Arg Arg Ala 
            20                  25                  30          


Leu Gly Ala Leu Ala Ala Ala Leu Arg Glu Arg Gly Gly Arg Leu Gly 
        35                  40                  45              


Ala Ala Ala Pro Arg Val Leu Lys Thr Val Lys Gly Gly Ser Ser Gly 
    50                  55                  60                  


Arg Gly Thr Ala Leu Lys Gly Gly Cys Asp Ser Glu Leu Val Ile Phe 
65                  70                  75                  80  


Leu Asp Cys Phe Lys Ser Tyr Val Asp Gln Arg Ala Arg Arg Ala Glu 
                85                  90                  95      


Ile Leu Ser Glu Met Arg Ala Ser Leu Glu Ser Trp Trp Gln Asn Pro 
            100                 105                 110         


Val Pro Gly Leu Arg Leu Thr Phe Pro Glu Gln Ser Val Pro Gly Ala 
        115                 120                 125             


Leu Gln Phe Arg Leu Thr Ser Val Asp Leu Glu Asp Trp Met Asp Val 
    130                 135                 140                 


Ser Leu Val Pro Ala Phe Asn Val Leu Gly Gln Ala Gly Ser Gly Val 
145                 150                 155                 160 


Lys Pro Lys Pro Gln Val Tyr Ser Thr Leu Leu Asn Ser Gly Cys Gln 
                165                 170                 175     


Gly Gly Glu His Ala Ala Cys Phe Thr Glu Leu Arg Arg Asn Phe Val 
            180                 185                 190         


Asn Ile Arg Pro Ala Lys Leu Lys Asn Leu Ile Leu Leu Val Lys His 
        195                 200                 205             


Trp Tyr His Gln Val Cys Leu Gln Gly Leu Trp Lys Glu Thr Leu Pro 
    210                 215                 220                 


Pro Val Tyr Ala Leu Glu Leu Leu Thr Ile Phe Ala Trp Glu Gln Gly 
225                 230                 235                 240 


Cys Lys Lys Asp Ala Phe Ser Leu Ala Glu Gly Leu Arg Thr Val Leu 
                245                 250                 255     


Gly Leu Ile Gln Gln His Gln His Leu Cys Val Phe Trp Thr Val Asn 
            260                 265                 270         


Tyr Gly Phe Glu Asp Pro Ala Val Gly Gln Phe Leu Gln Arg Gln Leu 
        275                 280                 285             


Lys Arg Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro Thr Trp Asp 
    290                 295                 300                 


Leu Gly Asn Gly Ala Ala Trp His Trp Asp Leu Leu Ala Gln Glu Ala 
305                 310                 315                 320 


Ala Ser Cys Tyr Asp His Pro Cys Phe Leu Arg Gly Met Gly Asp Pro 
                325                 330                 335     


Val Gln Ser Trp Lys Gly Pro Gly Leu Pro Arg Ala Gly Cys Ser Gly 
            340                 345                 350         


Leu Gly His Pro Ile Gln Leu Asp Pro Asn Gln Lys Thr Pro Glu Asn 
        355                 360                 365             


Ser Lys Ser Leu Asn Ala Val Tyr Pro Arg Ala Gly Ser Lys Pro Pro 
    370                 375                 380                 


Ser Cys Pro Ala Pro Gly Pro Thr Gly Ala Ala Ser Ile Val Pro Ser 
385                 390                 395                 400 


Val Pro Gly Met Ala Leu Asp Leu Ser Gln Ile Pro Thr Lys Glu Leu 
                405                 410                 415     


Asp Arg Phe Ile Gln Asp His Leu Lys Pro Ser Pro Gln Phe Gln Glu 
            420                 425                 430         


Gln Val Lys Lys Ala Ile Asp Ile Ile Leu Arg Cys Leu His Glu Asn 
        435                 440                 445             


Cys Val His Lys Ala Ser Arg Val Ser Lys Gly Gly Ser Phe Gly Arg 
    450                 455                 460                 


Gly Thr Asp Leu Arg Asp Gly Cys Asp Val Glu Leu Ile Ile Phe Leu 
465                 470                 475                 480 


Asn Cys Phe Thr Asp Tyr Lys Asp Gln Gly Pro Arg Arg Ala Glu Ile 
                485                 490                 495     


Leu Asp Glu Met Arg Ala Gln Leu Glu Ser Trp Trp Gln Asp Gln Val 
            500                 505                 510         


Pro Ser Leu Ser Leu Gln Phe Pro Glu Gln Asn Val Pro Glu Ala Leu 
        515                 520                 525             


Gln Phe Gln Leu Val Ser Thr Ala Leu Lys Ser Trp Thr Asp Val Ser 
    530                 535                 540                 


Leu Leu Pro Ala Phe Asp Ala Val Gly Gln Leu Ser Ser Gly Thr Lys 
545                 550                 555                 560 


Pro Asn Pro Gln Val Tyr Ser Arg Leu Leu Thr Ser Gly Cys Gln Glu 
                565                 570                 575     


Gly Glu His Lys Ala Cys Phe Ala Glu Leu Arg Arg Asn Phe Met Asn 
            580                 585                 590         


Ile Arg Pro Val Lys Leu Lys Asn Leu Ile Leu Leu Val Lys His Trp 
        595                 600                 605             


Tyr Arg Gln Val Ala Ala Gln Asn Lys Gly Lys Gly Pro Ala Pro Ala 
    610                 615                 620                 


Ser Leu Pro Pro Ala Tyr Ala Leu Glu Leu Leu Thr Ile Phe Ala Trp 
625                 630                 635                 640 


Glu Gln Gly Cys Arg Gln Asp Cys Phe Asn Met Ala Gln Gly Phe Arg 
                645                 650                 655     


Thr Val Leu Gly Leu Val Gln Gln His Gln Gln Leu Cys Val Tyr Trp 
            660                 665                 670         


Thr Val Asn Tyr Ser Thr Glu Asp Pro Ala Met Arg Met His Leu Leu 
        675                 680                 685             


Gly Gln Leu Arg Lys Pro Arg Pro Leu Val Leu Asp Pro Ala Asp Pro 
    690                 695                 700                 


Thr Trp Asn Val Gly His Gly Ser Trp Glu Leu Leu Ala Gln Glu Ala 
705                 710                 715                 720 


Ala Ala Leu Gly Met Gln Ala Cys Phe Leu Ser Arg Asp Gly Thr Ser 
                725                 730                 735     


Val Gln Pro Trp Asp Val Met Pro Ala Leu Leu Tyr Gln Thr Pro Ala 
            740                 745                 750         


Gly Asp Leu Asp Lys Phe Ile Ser Glu Phe Leu Gln Pro Asn Arg Gln 
        755                 760                 765             


Phe Leu Ala Gln Val Asn Lys Ala Val Asp Thr Ile Cys Ser Phe Leu 
    770                 775                 780                 


Lys Glu Asn Cys Phe Arg Asn Ser Pro Ile Lys Val Ile Lys Val Val 
785                 790                 795                 800 


Lys Gly Gly Ser Ser Ala Lys Gly Thr Ala Leu Arg Gly Arg Ser Asp 
                805                 810                 815     


Ala Asp Leu Val Val Phe Leu Ser Cys Phe Ser Gln Phe Thr Glu Gln 
            820                 825                 830         


Gly Asn Lys Arg Ala Glu Ile Ile Ser Glu Ile Arg Ala Gln Leu Glu 
        835                 840                 845             


Ala Cys Gln Gln Glu Arg Gln Phe Glu Val Lys Phe Glu Val Ser Lys 
    850                 855                 860                 


Trp Glu Asn Pro Arg Val Leu Ser Phe Ser Leu Thr Ser Gln Thr Met 
865                 870                 875                 880 


Leu Asp Gln Ser Val Asp Phe Asp Val Leu Pro Ala Phe Asp Ala Leu 
                885                 890                 895     


Gly Gln Leu Val Ser Gly Ser Arg Pro Ser Ser Gln Val Tyr Val Asp 
            900                 905                 910         


Leu Ile His Ser Tyr Ser Asn Ala Gly Glu Tyr Ser Thr Cys Phe Thr 
        915                 920                 925             


Glu Leu Gln Arg Asp Phe Ile Ile Ser Arg Pro Thr Lys Leu Lys Ser 
    930                 935                 940                 


Leu Ile Arg Leu Val Lys His Trp Tyr Gln Gln Cys Thr Lys Ile Ser 
945                 950                 955                 960 


Lys Gly Arg Gly Ser Leu Pro Pro Gln His Gly Leu Glu Leu Leu Thr 
                965                 970                 975     


Val Tyr Ala Trp Glu Gln Gly Gly Lys Asp Ser Gln Phe Asn Met Ala 
            980                 985                 990         


Glu Gly Phe Arg Thr Val Leu Glu  Leu Val Thr Gln Tyr  Arg Gln Leu 
        995                 1000                 1005             


Cys Ile  Tyr Trp Thr Ile Asn  Tyr Asn Ala Lys Asp  Lys Thr Val 
    1010                 1015                 1020             


Gly Asp  Phe Leu Lys Gln Gln  Leu Gln Lys Pro Arg  Pro Ile Ile 
    1025                 1030                 1035             


Leu Asp  Pro Ala Asp Pro Thr  Gly Asn Leu Gly His  Asn Ala Arg 
    1040                 1045                 1050             


Trp Asp  Leu Leu Ala Lys Glu  Ala Ala Ala Cys Thr  Ser Ala Leu 
    1055                 1060                 1065             


Cys Cys  Met Gly Arg Asn Gly  Ile Pro Ile Gln Pro  Trp Pro Val 
    1070                 1075                 1080             


Lys Ala  Ala Val 
    1085         


<210>  3014
<211>  2123
<212>  DNA
<213>  Homosapiens

<400>  3014
caagagttgg taagctcgct gcagtgggtg gagagaggcc tctagacttc agtttcagtt     60

tcctggctct gggcagcagc aagaattcct ctgcctccca tcctaccatt cactgtcttg    120

ccggcagcca gctgagagca atgggaaatg gggagtccca gctgtcctcg gtgcctgctc    180

agaagctggg ttggtttatc caggaatacc tgaagcccta cgaagaatgt cagacactga    240

tcgacgagat ggtgaacacc atctgtgacg tcctgcagga acccgaacag ttccccctgg    300

tgcagggagt ggccataggt ggctcctatg gacggaaaac agtcttaaga ggcaactccg    360

atggtaccct tgtcctcttc ttcagtgact taaaacaatt ccaggatcag aagagaagcc    420

aacgtgacat cctcgataaa actggggata agctgaagtt ctgtctgttc acgaagtggt    480

tgaaaaacaa tttcgagatc cagaagtccc ttgatgggtt caccatccag gtgttcacaa    540

aaaatcagag aatctctttc gaggtgctgg ccgccttcaa cgctctgagt aagcattgct    600

gggtgtcagg agagaaaagc caaagaagcg ggtgccagac agctctgtgc aacctctagg    660

ccatgagtgg gatagatacc actgctgctt taaaaaatgg gagaccatag accctcagga    720

gagaagaatc ccttctaccc tggactcgct ctcttctctg gaactaactt ctcccccata    780

ccctgattgt ctttggagaa aatgttctgg attctagaat ctaaggcaga gccttttaag    840

ccatactgta cacataaatc acctggaacc ttgttaaaat gcagatcctg actcaggagg    900

tctgagttag agcccaggat ttcatatttc tagccagctc catgatgagc tgctggtccg    960

cagatcatgc ttgcaggttt tgaccagagt cagtgttggt tagagtaaga ggatgaggca   1020

gacatctggg aaaagtccag ctggggcaag catttgaagt ctgccttcct accaggtcaa   1080

aatcaaggca acgaccttcc atagataact atcaaagctt gagggggtgc cttgaaccca   1140

actcctaaat ccctaagacc tgcccacctc ttgtgtctcc tgtctcagca aacattccca   1200

cactcttgca tattgttaaa gtaacctctg cttaccaggc ttctggttta ataaaagatg   1260

gctagagtga ctccatctta aagcaagtag ctaggcactc aaaaggaacc tacaggctta   1320

atacttgggt ctgaaaatag ccacagtcta agctgaccac caattataat tgcagaatat   1380

ttaaggccat acaaaacatc tcccactaag cctacaaaat gtccaggtgt cctaaaagtt   1440

cagcccactt aaaggcagca ttaatgagca ggtttaggtt gaaggattaa tggtcatcaa   1500

taccactgtt aagaagaaaa ttcttggcca aattgaattt aatggagttt aactgagcag   1560

acaattcaca aatctagaag cctcctgagc cagagtaggt tcagagagtc ttgaacacag   1620

ccacgtggtg gaagaagatt tatggacagg aaaaggaaaa tgatgtactg aaaatgaaag   1680

tgaggtacag aaacagccag actggttata gctcagcatt ggccttattt gaacgagatt   1740

tgaacagttg gccacctttg attggccgaa actcagtgat tggcacaaga gtaggttgca   1800

gtctgtttac acatcctttt aggttatagt tcaccatgta cagagaaatt ttaggccaaa   1860

cttaaaatat gtaaggaggc agctttaggc taaacttgat ttaacagcac caataccccc   1920

tacctttagt gagcacatct gcacattcca attttaatga cagctcctta gaatttctta   1980

tcaacgaaga cactaacaaa gaatggcgca ttcctccttc tcctttctga ggatgcccta   2040

ccctgtaaca aagtcgtttc taataaattt gcttctttca ccataaaaaa aaaaaaaaaa   2100

aaaaaaaaaa aaaaaaaaaa aaa                                           2123


<210>  3015
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  3015

Met Gly Asn Gly Glu Ser Gln Leu Ser Ser Val Pro Ala Gln Lys Leu 
1               5                   10                  15      


Gly Trp Phe Ile Gln Glu Tyr Leu Lys Pro Tyr Glu Glu Cys Gln Thr 
            20                  25                  30          


Leu Ile Asp Glu Met Val Asn Thr Ile Cys Asp Val Leu Gln Glu Pro 
        35                  40                  45              


Glu Gln Phe Pro Leu Val Gln Gly Val Ala Ile Gly Gly Ser Tyr Gly 
    50                  55                  60                  


Arg Lys Thr Val Leu Arg Gly Asn Ser Asp Gly Thr Leu Val Leu Phe 
65                  70                  75                  80  


Phe Ser Asp Leu Lys Gln Phe Gln Asp Gln Lys Arg Ser Gln Arg Asp 
                85                  90                  95      


Ile Leu Asp Lys Thr Gly Asp Lys Leu Lys Phe Cys Leu Phe Thr Lys 
            100                 105                 110         


Trp Leu Lys Asn Asn Phe Glu Ile Gln Lys Ser Leu Asp Gly Phe Thr 
        115                 120                 125             


Ile Gln Val Phe Thr Lys Asn Gln Arg Ile Ser Phe Glu Val Leu Ala 
    130                 135                 140                 


Ala Phe Asn Ala Leu Ser Lys His Cys Trp Val Ser Gly Glu Lys Ser 
145                 150                 155                 160 


Gln Arg Ser Gly Cys Gln Thr Ala Leu Cys Asn Leu 
                165                 170         


<210>  3016
<211>  3647
<212>  DNA
<213>  Homosapiens

<400>  3016
caagagttgg taagctcgct gcagtgggtg gagagaggcc tctagacttc agtttcagtt     60

tcctggctct gggcagcagc aagaattcct ctgcctccca tcctaccatt cactgtcttg    120

ccggcagcca gctgagagca atgggaaatg gggagtccca gctgtcctcg gtgcctgctc    180

agaagctggg ttggtttatc caggaatacc tgaagcccta cgaagaatgt cagacactga    240

tcgacgagat ggtgaacacc atctgtgacg tcctgcagga acccgaacag ttccccctgg    300

tgcagggagt ggccataggt ggctcctatg gacggaaaac agtcttaaga ggcaactccg    360

atggtaccct tgtcctcttc ttcagtgact taaaacaatt ccaggatcag aagagaagcc    420

aacgtgacat cctcgataaa actggggata agctgaagtt ctgtctgttc acgaagtggt    480

tgaaaaacaa tttcgagatc cagaagtccc ttgatgggtt caccatccag gtgttcacaa    540

aaaatcagag aatctctttc gaggtgctgg ccgccttcaa cgctctgagc ttaaatgata    600

atcccagccc ctggatctat cgagagctca aaagatcctt ggataagaca aatgccagtc    660

ctggtgagtt tgcagtctgc ttcactgaac tccagcagaa gttttttgac aaccgtcctg    720

gaaaactaaa ggatttgatc ctcttgataa agcactggca tcaacagtgc cagaaaaaaa    780

tcaaggattt accctcgctg tctccgtatg ccctggagct gcttacggtg tatgcctggg    840

aacaggggtg cagaaaagac aactttgaca ttgctgaagg cgtcagaacc gtactggagc    900

tgatcaaatg ccaggagaag ctgtgtatct attggatggt caactacaac tttgaagatg    960

agaccatcag gaacatcctg ctgcaccagc tccaatcagc gaggccagta atcttggatc   1020

cagttgaccc aaccaataat gtgagtggag ataaaatatg ctggcaatgg ctgaaaaaag   1080

aagctcaaac ctggttgact tctcccaacc tggataatga gttacctgca ccatcttgga   1140

atgttctgcc tgcaccactc ttcacgaccc caggccacct tctggataag ttcatcaagg   1200

agtttctcca gcccaacaaa tgcttcctag agcagattga cagtgctgtt aacatcatcc   1260

gtacattcct taaagaaaac tgcttccgac aatcaacagc caagatccag attgtccggg   1320

gaggatcaac cgccaaaggc acagctctga agactggctc tgatgccgat ctcgtcgtgt   1380

tccataactc acttaaaagc tacacctccc aaaaaaacga gcggcacaaa atcgtcaagg   1440

aaatccatga acagctgaaa gccttttgga gggagaagga ggaggagctt gaagtcagct   1500

ttgagcctcc caagtggaag gctcccaggg tgctgagctt ctctctgaaa tccaaagtcc   1560

tcaacgaaag tgtcagcttt gatgtgcttc ctgcctttaa tgcactgggt cagctgagtt   1620

ctggctccac acccagcccc gaggtttatg cagggctcat tgatctgtat aaatcctcgg   1680

acctcccggg aggagagttt tctacctgtt tcacagtcct gcagcgaaac ttcattcgct   1740

cccggcccac caaactaaag gatttaattc gcctggtgaa gcactggtac aaagagtgtg   1800

aaaggaaact gaagccaaag gggtctttgc ccccaaagta tgccttggag ctgctcacca   1860

tctatgcctg ggagcagggg agtggagtgc cggattttga cactgcagaa ggtttccgga   1920

cagtcctgga gctggtcaca caatatcagc agctctgcat cttctggaag gtcaattaca   1980

actttgaaga tgagaccgtg aggaagtttc tactgagcca gttgcagaaa accaggcctg   2040

tgatcttgga cccagccgaa cccacaggtg acgtgggtgg aggggaccgt tggtgttggc   2100

atcttctggc aaaagaagca aaggaatggt tatcctctcc ctgcttcaag gatgggactg   2160

gaaacccaat accaccttgg aaagtgccgg taaaagtcat ctaaaggagg cgttgtctgg   2220

aaatagccct gtaacaggct tgaatcaaag aacttctcct actgtagcaa cctgaaatta   2280

actcagacac aaataaagga aacccagctc acaggagctt aaacagctgg tcagccccct   2340

aagcccccac tacaagtgat cctcaggcag gtaaccccag attcatgcac tgtagggtgc   2400

tgcgcagcat ccctagtctc tacccagtag atgccactag ccctcctctc ccagtgacaa   2460

ccaaaagtct tcagacattg tcaaacgttc ccctgggttc acagatcttt ctgcctttgg   2520

cttttggctc caccctcttt agctgttaat ttgagtactt atggccctga aagcggccac   2580

ggtgcctcca gatggcaggt ttgcaatcca agcaggaaga aggaaaagat acccaaaggt   2640

caagaacaca gtgattttat tagaagtttc atccgcaaat tttcttccat ttcattgctc   2700

agaaatgtca tgtggctacc tgtaacttga aggtggctac aaagatgact gtggacgtgg   2760

gttgcactgg ccacccaagg atgtctgcca cacctctcca aagccctccc tacctaccaa   2820

gatatacctg atatattcca ccaggatatc ctccctccag atatacttgg ttctctccac   2880

caggttcttt ctttaaagca ggatttctca actttgatac ttactcacat ttggggctag   2940

acagttcttt gtttggaggc tctcttgtgc attgtaggat gttgagcagc atctctggcc   3000

tgtacccagt agatgccacc cagttgtgac aattaaaagt gtcttgagac tttatcatgt   3060

gtcttctgcc ctaggtgaga acccttgcac tagaggaacc ctacacccca accctggggg   3120

gaatgtaggg aagaggtggc caagccaacc gtggggttag ctctaattat taagatatgc   3180

attataaata aataccaaaa aattgtctct ggcaatagtt accttcccag atacaggtcc   3240

cccctttttt cccctaactc ttttaagcaa tgattgtaac tattaggaga cattgctctc   3300

ccacgtatgt ttttcttttt agacaatgca gacaccagga agttgtggag ctaggatcca   3360

tcctattgtc aatgagatgt tctcatccag aagccataga atcctgaata ataattctaa   3420

aagaaacttc tagagatcat ctggcaatcg cttttaaaga ctcggctcac cgtgagaaag   3480

agtcactcac atccattctt cccttgatgg tccctattcc tccttccctt gcttcttgga   3540

cttcttgaaa tcaatcaaga ctgcaaaccc tttcataaag tcttgccttg ctgaactccc   3600

tctctgcagg cagcctgcct ttaaaaatag ttgctgtcat ccacttt                 3647


<210>  3017
<211>  687
<212>  PRT
<213>  Homosapiens

<400>  3017

Met Gly Asn Gly Glu Ser Gln Leu Ser Ser Val Pro Ala Gln Lys Leu 
1               5                   10                  15      


Gly Trp Phe Ile Gln Glu Tyr Leu Lys Pro Tyr Glu Glu Cys Gln Thr 
            20                  25                  30          


Leu Ile Asp Glu Met Val Asn Thr Ile Cys Asp Val Leu Gln Glu Pro 
        35                  40                  45              


Glu Gln Phe Pro Leu Val Gln Gly Val Ala Ile Gly Gly Ser Tyr Gly 
    50                  55                  60                  


Arg Lys Thr Val Leu Arg Gly Asn Ser Asp Gly Thr Leu Val Leu Phe 
65                  70                  75                  80  


Phe Ser Asp Leu Lys Gln Phe Gln Asp Gln Lys Arg Ser Gln Arg Asp 
                85                  90                  95      


Ile Leu Asp Lys Thr Gly Asp Lys Leu Lys Phe Cys Leu Phe Thr Lys 
            100                 105                 110         


Trp Leu Lys Asn Asn Phe Glu Ile Gln Lys Ser Leu Asp Gly Phe Thr 
        115                 120                 125             


Ile Gln Val Phe Thr Lys Asn Gln Arg Ile Ser Phe Glu Val Leu Ala 
    130                 135                 140                 


Ala Phe Asn Ala Leu Ser Leu Asn Asp Asn Pro Ser Pro Trp Ile Tyr 
145                 150                 155                 160 


Arg Glu Leu Lys Arg Ser Leu Asp Lys Thr Asn Ala Ser Pro Gly Glu 
                165                 170                 175     


Phe Ala Val Cys Phe Thr Glu Leu Gln Gln Lys Phe Phe Asp Asn Arg 
            180                 185                 190         


Pro Gly Lys Leu Lys Asp Leu Ile Leu Leu Ile Lys His Trp His Gln 
        195                 200                 205             


Gln Cys Gln Lys Lys Ile Lys Asp Leu Pro Ser Leu Ser Pro Tyr Ala 
    210                 215                 220                 


Leu Glu Leu Leu Thr Val Tyr Ala Trp Glu Gln Gly Cys Arg Lys Asp 
225                 230                 235                 240 


Asn Phe Asp Ile Ala Glu Gly Val Arg Thr Val Leu Glu Leu Ile Lys 
                245                 250                 255     


Cys Gln Glu Lys Leu Cys Ile Tyr Trp Met Val Asn Tyr Asn Phe Glu 
            260                 265                 270         


Asp Glu Thr Ile Arg Asn Ile Leu Leu His Gln Leu Gln Ser Ala Arg 
        275                 280                 285             


Pro Val Ile Leu Asp Pro Val Asp Pro Thr Asn Asn Val Ser Gly Asp 
    290                 295                 300                 


Lys Ile Cys Trp Gln Trp Leu Lys Lys Glu Ala Gln Thr Trp Leu Thr 
305                 310                 315                 320 


Ser Pro Asn Leu Asp Asn Glu Leu Pro Ala Pro Ser Trp Asn Val Leu 
                325                 330                 335     


Pro Ala Pro Leu Phe Thr Thr Pro Gly His Leu Leu Asp Lys Phe Ile 
            340                 345                 350         


Lys Glu Phe Leu Gln Pro Asn Lys Cys Phe Leu Glu Gln Ile Asp Ser 
        355                 360                 365             


Ala Val Asn Ile Ile Arg Thr Phe Leu Lys Glu Asn Cys Phe Arg Gln 
    370                 375                 380                 


Ser Thr Ala Lys Ile Gln Ile Val Arg Gly Gly Ser Thr Ala Lys Gly 
385                 390                 395                 400 


Thr Ala Leu Lys Thr Gly Ser Asp Ala Asp Leu Val Val Phe His Asn 
                405                 410                 415     


Ser Leu Lys Ser Tyr Thr Ser Gln Lys Asn Glu Arg His Lys Ile Val 
            420                 425                 430         


Lys Glu Ile His Glu Gln Leu Lys Ala Phe Trp Arg Glu Lys Glu Glu 
        435                 440                 445             


Glu Leu Glu Val Ser Phe Glu Pro Pro Lys Trp Lys Ala Pro Arg Val 
    450                 455                 460                 


Leu Ser Phe Ser Leu Lys Ser Lys Val Leu Asn Glu Ser Val Ser Phe 
465                 470                 475                 480 


Asp Val Leu Pro Ala Phe Asn Ala Leu Gly Gln Leu Ser Ser Gly Ser 
                485                 490                 495     


Thr Pro Ser Pro Glu Val Tyr Ala Gly Leu Ile Asp Leu Tyr Lys Ser 
            500                 505                 510         


Ser Asp Leu Pro Gly Gly Glu Phe Ser Thr Cys Phe Thr Val Leu Gln 
        515                 520                 525             


Arg Asn Phe Ile Arg Ser Arg Pro Thr Lys Leu Lys Asp Leu Ile Arg 
    530                 535                 540                 


Leu Val Lys His Trp Tyr Lys Glu Cys Glu Arg Lys Leu Lys Pro Lys 
545                 550                 555                 560 


Gly Ser Leu Pro Pro Lys Tyr Ala Leu Glu Leu Leu Thr Ile Tyr Ala 
                565                 570                 575     


Trp Glu Gln Gly Ser Gly Val Pro Asp Phe Asp Thr Ala Glu Gly Phe 
            580                 585                 590         


Arg Thr Val Leu Glu Leu Val Thr Gln Tyr Gln Gln Leu Cys Ile Phe 
        595                 600                 605             


Trp Lys Val Asn Tyr Asn Phe Glu Asp Glu Thr Val Arg Lys Phe Leu 
    610                 615                 620                 


Leu Ser Gln Leu Gln Lys Thr Arg Pro Val Ile Leu Asp Pro Ala Glu 
625                 630                 635                 640 


Pro Thr Gly Asp Val Gly Gly Gly Asp Arg Trp Cys Trp His Leu Leu 
                645                 650                 655     


Ala Lys Glu Ala Lys Glu Trp Leu Ser Ser Pro Cys Phe Lys Asp Gly 
            660                 665                 670         


Thr Gly Asn Pro Ile Pro Pro Trp Lys Val Pro Val Lys Val Ile 
        675                 680                 685         


<210>  3018
<211>  3539
<212>  DNA
<213>  Homosapiens

<400>  3018
caagagttgg taagctcgct gcagtgggtg gagagaggcc tctagacttc agtttcagtt     60

tcctggctct gggcagcagc aagaattcct ctgcctccca tcctaccatt cactgtcttg    120

ccggcagcca gctgagagca atgggaaatg gggagtccca gctgtcctcg gtgcctgctc    180

agaagctggg ttggtttatc caggaatacc tgaagcccta cgaagaatgt cagacactga    240

tcgacgagat ggtgaacacc atctgtgacg tcctgcagga acccgaacag ttccccctgg    300

tgcagggagt ggccataggt ggctcctatg gacggaaaac agtcttaaga ggcaactccg    360

atggtaccct tgtcctcttc ttcagtgact taaaacaatt ccaggatcag aagagaagcc    420

aacgtgacat cctcgataaa actggggata agctgaagtt ctgtctgttc acgaagtggt    480

tgaaaaacaa tttcgagatc cagaagtccc ttgatgggtt caccatccag gtgttcacaa    540

aaaatcagag aatctctttc gaggtgctgg ccgccttcaa cgctctgagc ttaaatgata    600

atcccagccc ctggatctat cgagagctca aaagatcctt ggataagaca aatgccagtc    660

ctggtgagtt tgcagtctgc ttcactgaac tccagcagaa gttttttgac aaccgtcctg    720

gaaaactaaa ggatttgatc ctcttgataa agcactggca tcaacagtgc cagaaaaaaa    780

tcaaggattt accctcgctg tctccgtatg ccctggagct gcttacggtg tatgcctggg    840

aacaggggtg cagaaaagac aactttgaca ttgctgaagg cgtcagaacc gtactggagc    900

tgatcaaatg ccaggagaag ctgtgtatct attggatggt caactacaac tttgaagatg    960

agaccatcag gaacatcctg ctgcaccagc tccaatcagc gaggccagta atcttggatc   1020

cagttgaccc aaccaataat gtgagtggag ataaaatatg ctggcaatgg ctgaaaaaag   1080

aagctcaaac ctggttgact tctcccaacc tggataatga gttacctgca ccatcttgga   1140

atgttctgcc tgcaccactc ttcacgaccc caggccacct tctggataag ttcatcaagg   1200

agtttctcca gcccaacaaa tgcttcctag agcagattga cagtgctgtt aacatcatcc   1260

gtacattcct taaagaaaac tgcttccgac aatcaacagc caagatccag attgtccggg   1320

gaggatcaac cgccaaaggc acagctctga agactggctc tgatgccgat ctcgtcgtgt   1380

tccataactc acttaaaagc tacacctccc aaaaaaacga gcggcacaaa atcgtcaagg   1440

aaatccatga acagctgaaa gccttttgga gggagaagga ggaggagctt gaagtcagct   1500

ttgagcctcc caagtggaag gctcccaggg tgctgagctt ctctctgaaa tccaaagtcc   1560

tcaacgaaag tgtcagcttt gatgtgcttc ctgcctttaa tgcactgggt cagctgagtt   1620

ctggctccac acccagcccc gaggtttatg cagggctcat tgatctgtat aaatcctcgg   1680

acctcccggg aggagagttt tctacctgtt tcacagtcct gcagcgaaac ttcattcgct   1740

cccggcccac caaactaaag gatttaattc gcctggtgaa gcactggtac aaagagtgtg   1800

aaaggaaact gaagccaaag gggtctttgc ccccaaagta tgccttggag ctgctcacca   1860

tctatgcctg ggagcagggg agtggagtgc cggattttga cactgcagaa ggtttccgga   1920

cagtcctgga gctggtcaca caatatcagc agctctgcat cttctggaag gtcaattaca   1980

actttgaaga tgagaccgtg aggaagtttc tactgagcca gttgcagaaa accaggcctg   2040

tgatcttgga cccagccgaa cccacaggtg acgtgggtgg aggggaccgt tggtgttggc   2100

atcttctggc aaaagaagca aaggaatggt tatcctctcc ctgcttcaag gatgggactg   2160

gaaacccaat accaccttgg aaagtgccga caatgcagac accaggaagt tgtggagcta   2220

ggatccatcc tattgtcaat gagatgttct catccagaag ccatagaatc ctgaataata   2280

attctaaaag aaacttctag agatcatctg gcaatcgctt ttaaagactc ggctcaccgt   2340

gagaaagagt cactcacatc cattcttccc ttgatggtcc ctattcctcc ttcccttgct   2400

tcttggactt cttgaaatca atcaagactg caaacccttt cataaagtct tgccttgctg   2460

aactccctct ctgcaggcag cctgccttta aaaatagttg ctgtcatcca ctttatgtgc   2520

atcttatttc tgtcaacttg tatttttttt cttgtatttt tccaattagc tcctcctttt   2580

tccttccagt ctaaaaaagg aatcctctgt gtcttcaaag caaagctctt tactttcccc   2640

ttggttctca taactctgtg atcttgctct cggtgcttcc aactcatcca cgtcctgtct   2700

gtttcctctg tatacaaaac cctttctgcc cctgctgaca cagacatcct ctatgccagc   2760

agccagccaa ccctttcatt agaacttcaa gctctccaaa ggctcagatt ataactgttg   2820

tcatatttat atgaggctgt tgtcttttcc ttctgagcct gcctttctcc cccccaccca   2880

ggagtatcct cttgccaaat caaaagactt tttccttggg ctttagcctt aaagatactt   2940

gaaggtctag gtgctttaac ctcacatacc ctcacttaaa cttttatcac tgttgcatat   3000

accagttgtg atacaataaa gaatgtatct ggattttgtg cctagttcct agcacacagc   3060

ttcaaaaatt ctagagtttc ctgataggag tgtcttttgt attcataaca agcccttttc   3120

acccatgcct gggtttatgc taacaaggtt acccatggtg ggcccttagt ttcaaggaag   3180

gagttggcca agccagaaag accaagcatg tggttaaagc attggaattt tcagccccat   3240

cccaccccca atctccaagg aggtgatggg gctggaaatt gagttcaatt ttaacatggc   3300

cagtgattta agcaatgctg cctatgtaaa gaaaccccaa taaaaactct ggacagtgag   3360

gcttggggag cttcctgatt ggcagacatt ccaatgtact aggaaggtag cgcatcttga   3420

ttccacaggg acaaaggctc ctgagctctg ggcccttcca gtgcttgcca ccctacatac   3480

tctttgtctg gctcttcatt tgtattcttt ataataaaat ggtgattgta agtagagca    3539


<210>  3019
<211>  719
<212>  PRT
<213>  Homosapiens

<400>  3019

Met Gly Asn Gly Glu Ser Gln Leu Ser Ser Val Pro Ala Gln Lys Leu 
1               5                   10                  15      


Gly Trp Phe Ile Gln Glu Tyr Leu Lys Pro Tyr Glu Glu Cys Gln Thr 
            20                  25                  30          


Leu Ile Asp Glu Met Val Asn Thr Ile Cys Asp Val Leu Gln Glu Pro 
        35                  40                  45              


Glu Gln Phe Pro Leu Val Gln Gly Val Ala Ile Gly Gly Ser Tyr Gly 
    50                  55                  60                  


Arg Lys Thr Val Leu Arg Gly Asn Ser Asp Gly Thr Leu Val Leu Phe 
65                  70                  75                  80  


Phe Ser Asp Leu Lys Gln Phe Gln Asp Gln Lys Arg Ser Gln Arg Asp 
                85                  90                  95      


Ile Leu Asp Lys Thr Gly Asp Lys Leu Lys Phe Cys Leu Phe Thr Lys 
            100                 105                 110         


Trp Leu Lys Asn Asn Phe Glu Ile Gln Lys Ser Leu Asp Gly Phe Thr 
        115                 120                 125             


Ile Gln Val Phe Thr Lys Asn Gln Arg Ile Ser Phe Glu Val Leu Ala 
    130                 135                 140                 


Ala Phe Asn Ala Leu Ser Leu Asn Asp Asn Pro Ser Pro Trp Ile Tyr 
145                 150                 155                 160 


Arg Glu Leu Lys Arg Ser Leu Asp Lys Thr Asn Ala Ser Pro Gly Glu 
                165                 170                 175     


Phe Ala Val Cys Phe Thr Glu Leu Gln Gln Lys Phe Phe Asp Asn Arg 
            180                 185                 190         


Pro Gly Lys Leu Lys Asp Leu Ile Leu Leu Ile Lys His Trp His Gln 
        195                 200                 205             


Gln Cys Gln Lys Lys Ile Lys Asp Leu Pro Ser Leu Ser Pro Tyr Ala 
    210                 215                 220                 


Leu Glu Leu Leu Thr Val Tyr Ala Trp Glu Gln Gly Cys Arg Lys Asp 
225                 230                 235                 240 


Asn Phe Asp Ile Ala Glu Gly Val Arg Thr Val Leu Glu Leu Ile Lys 
                245                 250                 255     


Cys Gln Glu Lys Leu Cys Ile Tyr Trp Met Val Asn Tyr Asn Phe Glu 
            260                 265                 270         


Asp Glu Thr Ile Arg Asn Ile Leu Leu His Gln Leu Gln Ser Ala Arg 
        275                 280                 285             


Pro Val Ile Leu Asp Pro Val Asp Pro Thr Asn Asn Val Ser Gly Asp 
    290                 295                 300                 


Lys Ile Cys Trp Gln Trp Leu Lys Lys Glu Ala Gln Thr Trp Leu Thr 
305                 310                 315                 320 


Ser Pro Asn Leu Asp Asn Glu Leu Pro Ala Pro Ser Trp Asn Val Leu 
                325                 330                 335     


Pro Ala Pro Leu Phe Thr Thr Pro Gly His Leu Leu Asp Lys Phe Ile 
            340                 345                 350         


Lys Glu Phe Leu Gln Pro Asn Lys Cys Phe Leu Glu Gln Ile Asp Ser 
        355                 360                 365             


Ala Val Asn Ile Ile Arg Thr Phe Leu Lys Glu Asn Cys Phe Arg Gln 
    370                 375                 380                 


Ser Thr Ala Lys Ile Gln Ile Val Arg Gly Gly Ser Thr Ala Lys Gly 
385                 390                 395                 400 


Thr Ala Leu Lys Thr Gly Ser Asp Ala Asp Leu Val Val Phe His Asn 
                405                 410                 415     


Ser Leu Lys Ser Tyr Thr Ser Gln Lys Asn Glu Arg His Lys Ile Val 
            420                 425                 430         


Lys Glu Ile His Glu Gln Leu Lys Ala Phe Trp Arg Glu Lys Glu Glu 
        435                 440                 445             


Glu Leu Glu Val Ser Phe Glu Pro Pro Lys Trp Lys Ala Pro Arg Val 
    450                 455                 460                 


Leu Ser Phe Ser Leu Lys Ser Lys Val Leu Asn Glu Ser Val Ser Phe 
465                 470                 475                 480 


Asp Val Leu Pro Ala Phe Asn Ala Leu Gly Gln Leu Ser Ser Gly Ser 
                485                 490                 495     


Thr Pro Ser Pro Glu Val Tyr Ala Gly Leu Ile Asp Leu Tyr Lys Ser 
            500                 505                 510         


Ser Asp Leu Pro Gly Gly Glu Phe Ser Thr Cys Phe Thr Val Leu Gln 
        515                 520                 525             


Arg Asn Phe Ile Arg Ser Arg Pro Thr Lys Leu Lys Asp Leu Ile Arg 
    530                 535                 540                 


Leu Val Lys His Trp Tyr Lys Glu Cys Glu Arg Lys Leu Lys Pro Lys 
545                 550                 555                 560 


Gly Ser Leu Pro Pro Lys Tyr Ala Leu Glu Leu Leu Thr Ile Tyr Ala 
                565                 570                 575     


Trp Glu Gln Gly Ser Gly Val Pro Asp Phe Asp Thr Ala Glu Gly Phe 
            580                 585                 590         


Arg Thr Val Leu Glu Leu Val Thr Gln Tyr Gln Gln Leu Cys Ile Phe 
        595                 600                 605             


Trp Lys Val Asn Tyr Asn Phe Glu Asp Glu Thr Val Arg Lys Phe Leu 
    610                 615                 620                 


Leu Ser Gln Leu Gln Lys Thr Arg Pro Val Ile Leu Asp Pro Ala Glu 
625                 630                 635                 640 


Pro Thr Gly Asp Val Gly Gly Gly Asp Arg Trp Cys Trp His Leu Leu 
                645                 650                 655     


Ala Lys Glu Ala Lys Glu Trp Leu Ser Ser Pro Cys Phe Lys Asp Gly 
            660                 665                 670         


Thr Gly Asn Pro Ile Pro Pro Trp Lys Val Pro Thr Met Gln Thr Pro 
        675                 680                 685             


Gly Ser Cys Gly Ala Arg Ile His Pro Ile Val Asn Glu Met Phe Ser 
    690                 695                 700                 


Ser Arg Ser His Arg Ile Leu Asn Asn Asn Ser Lys Arg Asn Phe 
705                 710                 715                 


<210>  3020
<211>  3317
<212>  DNA
<213>  Homosapiens

<400>  3020
cgaacagggg cggctgcctc actccctacc tgagccagcc gagggggcca aggactttag     60

agctgtttcc tccggcataa gagagacact tgctttccag ggcagcaccc tttatcggag    120

aaggctctac agggaagggg tctttgcagc ctggatggcc atcccacatt cctttaacgg    180

aggtctctag gcctcagaga gaacccagag ttagaaagga ggccagacgg tccttgctgt    240

ccccctgggg agagaggaag ttgccgcctg ctgccaggcc caggaggagc tgggcctgca    300

atagtggggg acctggcccc tgaggcagtg gcggccatgt cacggccagg ccacggtggg    360

ctgatgcctg tgaatggtct gggcttccca ccgcagaacg tggcccgggt ggtggtgtgg    420

gagtggctga atgagcacag ccgctggcgg ccctacacgg ccaccgtgtg ccaccacatt    480

gagaacgtgc tgaaggagga cgctcgcggt tccgtggtcc tggggcaggt ggacgcccag    540

cttgtgccct acatcatcga cctgcagtcc atgcaccagt ttcgccagga cacaggcacc    600

atgcggcccg tgcggcgcaa cttctacgac ccgtcgtcgg cgccgggcaa gggcatcgtg    660

tgggagtggg agaacgacgg cggcgcatgg acggcctacg atatggacat ctgcatcacc    720

atccagaacg cctacgagaa gcagcacccg tggctcgacc tctcatcgct aggcttctgc    780

tacctcatct acttcaacag catgtcgcag atgaaccgcc agacgcgccg gcgccgccgc    840

ctgcgccgcc gcctggacct cgcctacccg ctcaccgtgg gctccatccc taagtcgcag    900

tcgtggcccg tgggcgccag ctcgggccag ccctgctcct gccagcagtg cctgctggtc    960

aacagcacgc gcgccgcctc caacgccatc ctggcctcgc agcgccgcaa ggcgcccccc   1020

gcgcccccgc tgccgccgcc gccgccacct ggagggcctc caggcgcgct tgccgtgcgc   1080

cccagcgcca ccttcacagg cgccgcgctc tgggcagcgc ccgccgccgg ccccgccgag   1140

cccgcgccgc ctcccggggc gcccccacgg agcccgggcg cccccggcgg agcgcgcacc   1200

ccggggcaga acaacctcaa ccggcccggg ccccagcgca ccaccagcgt gagcgcgcgc   1260

gcctccatcc cgccgggggt ccccgcactc ccggtgaaga acttgaatgg tactgggccg   1320

gtccatccgg ccctggcagg gatgaccggg atactgctgt gcgcggccgg gctgcccgtg   1380

tgcctgacgc gggcccccaa gcccatcctg cacccgccgc ccgtgagcaa gagcgacgtg   1440

aagcccgtgc ctggcgtgcc cggggtgtgc cgcaagacca agaagaagca ccttaaaaag   1500

agtaagaatc ccgaggatgt ggttcgaaga tacatgcaga aggtgaaaaa cccacctgat   1560

gaggactgca ccatctgcat ggagcgactg gtcacagcat caggctacga gggcgtgctt   1620

cggcacaagg gcgtgcggcc tgagctcgtg ggccgcctgg gccgctgtgg ccacatgtac   1680

cacctgctgt gcctcgtggc catgtactcc aatggcaaca aggatggcag cctgcagtgc   1740

cccacctgca aggccatcta cggggagaag acgggtacgc agccgcctgg gaagatggag   1800

ttccacctca tcccccactc gctgcccggc ttccctgata cccagaccat ccgcatcgtc   1860

tatgacatcc ccacaggcat ccagggccct gagcacccca accccgggaa gaagttcacc   1920

gcaagaggat tccctcgcca ctgctatcta cccaacaacg agaaaggccg gaaggtgctg   1980

cggctgctca tcacggcctg ggagagaaga ctcatcttca ctatcggcac gtccaacacc   2040

acgggcgagt cggacaccgt ggtgtggaac gagatccacc acaagaccga gtttggatcc   2100

aacctcacgg gccacggcta cccggacgct agctacctag acaacgtgct ggctgagctc   2160

acagcccagg gcgtatccga ggctgcagcc aaggcttgag gcccaaggct gcccaccttc   2220

cctcctgctt tgcccctggt ccggcaaatg cctccttcgc caggtgtgtc ctggtagccc   2280

aggttcaggg ctggggagga gcctgcggaa ggggccgcag ccattcaggg gacctgcctg   2340

gtggcagctg ggatgaagag agatggcatg tcaggctggc cccgaatcat agctccctga   2400

gagggccaag cagagagtac tggaaacctc cctaccaaaa agacagagac ccgccccctc   2460

acacacaaac acacatgtcc tgttgaactc atgcacgcac acccacgtgc ctgtacttgc   2520

ccccaggctg gaagagaaga gacagaaaga ccccatgacc cccccatgtg gatccccatc   2580

tgtgtctcag ttgcatctgt acagccttgt ctgcaaactg gaggatgcgg ggcaagccct   2640

taggggcctg ccagggctcg gggggcaaag agggactcgg gaaactcagt gtaccccaga   2700

tgcctcaccc attccgtgtc atcacccatg tctgccaccc actgattggg caattgtggg   2760

cccatggggt ggaagccccc agatgactga gcagttctac aaaagaatgg ccagcacgag   2820

cggggactag agggtcctga ttttgtgtct gtgcctcttc atctctctgg actctgatct   2880

ccttctccct tcccatctcc aggccttctg tctgtcccag ataaaggcgc tgttctccca   2940

tcctccctac cccatcctct ccaccaaatc gctcccaatt ttgagagcca aaggctggcg   3000

cttctgactt caggagcgaa aggaggaggc ctagtttggg ccgatgtatt ttaaagcaga   3060

gtggacagca gagagtcaat ttccctttcg ttgggagtgg gcagtggggt ggctaattgt   3120

cttcggccaa ccaggggcct gttgcccagg caactcacca gctccgcctc tgctgattgg   3180

ctgccacggt gggagtcagc caagatttaa agggatgcca gcgattgctc ttttcaaaac   3240

ctaccagtcc cactgtgggt ggagaaataa atggtctttc tcctcctcaa aaaaaaaaaa   3300

aaaaaaaaaa aaaaaaa                                                  3317


<210>  3021
<211>  620
<212>  PRT
<213>  Homosapiens

<400>  3021

Met Ser Arg Pro Gly His Gly Gly Leu Met Pro Val Asn Gly Leu Gly 
1               5                   10                  15      


Phe Pro Pro Gln Asn Val Ala Arg Val Val Val Trp Glu Trp Leu Asn 
            20                  25                  30          


Glu His Ser Arg Trp Arg Pro Tyr Thr Ala Thr Val Cys His His Ile 
        35                  40                  45              


Glu Asn Val Leu Lys Glu Asp Ala Arg Gly Ser Val Val Leu Gly Gln 
    50                  55                  60                  


Val Asp Ala Gln Leu Val Pro Tyr Ile Ile Asp Leu Gln Ser Met His 
65                  70                  75                  80  


Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Pro Val Arg Arg Asn Phe 
                85                  90                  95      


Tyr Asp Pro Ser Ser Ala Pro Gly Lys Gly Ile Val Trp Glu Trp Glu 
            100                 105                 110         


Asn Asp Gly Gly Ala Trp Thr Ala Tyr Asp Met Asp Ile Cys Ile Thr 
        115                 120                 125             


Ile Gln Asn Ala Tyr Glu Lys Gln His Pro Trp Leu Asp Leu Ser Ser 
    130                 135                 140                 


Leu Gly Phe Cys Tyr Leu Ile Tyr Phe Asn Ser Met Ser Gln Met Asn 
145                 150                 155                 160 


Arg Gln Thr Arg Arg Arg Arg Arg Leu Arg Arg Arg Leu Asp Leu Ala 
                165                 170                 175     


Tyr Pro Leu Thr Val Gly Ser Ile Pro Lys Ser Gln Ser Trp Pro Val 
            180                 185                 190         


Gly Ala Ser Ser Gly Gln Pro Cys Ser Cys Gln Gln Cys Leu Leu Val 
        195                 200                 205             


Asn Ser Thr Arg Ala Ala Ser Asn Ala Ile Leu Ala Ser Gln Arg Arg 
    210                 215                 220                 


Lys Ala Pro Pro Ala Pro Pro Leu Pro Pro Pro Pro Pro Pro Gly Gly 
225                 230                 235                 240 


Pro Pro Gly Ala Leu Ala Val Arg Pro Ser Ala Thr Phe Thr Gly Ala 
                245                 250                 255     


Ala Leu Trp Ala Ala Pro Ala Ala Gly Pro Ala Glu Pro Ala Pro Pro 
            260                 265                 270         


Pro Gly Ala Pro Pro Arg Ser Pro Gly Ala Pro Gly Gly Ala Arg Thr 
        275                 280                 285             


Pro Gly Gln Asn Asn Leu Asn Arg Pro Gly Pro Gln Arg Thr Thr Ser 
    290                 295                 300                 


Val Ser Ala Arg Ala Ser Ile Pro Pro Gly Val Pro Ala Leu Pro Val 
305                 310                 315                 320 


Lys Asn Leu Asn Gly Thr Gly Pro Val His Pro Ala Leu Ala Gly Met 
                325                 330                 335     


Thr Gly Ile Leu Leu Cys Ala Ala Gly Leu Pro Val Cys Leu Thr Arg 
            340                 345                 350         


Ala Pro Lys Pro Ile Leu His Pro Pro Pro Val Ser Lys Ser Asp Val 
        355                 360                 365             


Lys Pro Val Pro Gly Val Pro Gly Val Cys Arg Lys Thr Lys Lys Lys 
    370                 375                 380                 


His Leu Lys Lys Ser Lys Asn Pro Glu Asp Val Val Arg Arg Tyr Met 
385                 390                 395                 400 


Gln Lys Val Lys Asn Pro Pro Asp Glu Asp Cys Thr Ile Cys Met Glu 
                405                 410                 415     


Arg Leu Val Thr Ala Ser Gly Tyr Glu Gly Val Leu Arg His Lys Gly 
            420                 425                 430         


Val Arg Pro Glu Leu Val Gly Arg Leu Gly Arg Cys Gly His Met Tyr 
        435                 440                 445             


His Leu Leu Cys Leu Val Ala Met Tyr Ser Asn Gly Asn Lys Asp Gly 
    450                 455                 460                 


Ser Leu Gln Cys Pro Thr Cys Lys Ala Ile Tyr Gly Glu Lys Thr Gly 
465                 470                 475                 480 


Thr Gln Pro Pro Gly Lys Met Glu Phe His Leu Ile Pro His Ser Leu 
                485                 490                 495     


Pro Gly Phe Pro Asp Thr Gln Thr Ile Arg Ile Val Tyr Asp Ile Pro 
            500                 505                 510         


Thr Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Lys Phe Thr 
        515                 520                 525             


Ala Arg Gly Phe Pro Arg His Cys Tyr Leu Pro Asn Asn Glu Lys Gly 
    530                 535                 540                 


Arg Lys Val Leu Arg Leu Leu Ile Thr Ala Trp Glu Arg Arg Leu Ile 
545                 550                 555                 560 


Phe Thr Ile Gly Thr Ser Asn Thr Thr Gly Glu Ser Asp Thr Val Val 
                565                 570                 575     


Trp Asn Glu Ile His His Lys Thr Glu Phe Gly Ser Asn Leu Thr Gly 
            580                 585                 590         


His Gly Tyr Pro Asp Ala Ser Tyr Leu Asp Asn Val Leu Ala Glu Leu 
        595                 600                 605             


Thr Ala Gln Gly Val Ser Glu Ala Ala Ala Lys Ala 
    610                 615                 620 


<210>  3022
<211>  3148
<212>  DNA
<213>  Homosapiens

<400>  3022
agatggaagg ggatgttcaa agcccctccc ttgactctga acggaccccc agggaacatg     60

cgaccctctc tctggcgacg cctcccaccc accactaata cttgctcctg gaccgggggg    120

cgcggaggtt ggagagagga ggcaggtgtc tgcatgctac ccgggtctcg gacaggcggc    180

actgggacca cgaggcaggg agccaggctt gaagcaggtg acatgtagac gtcccctggt    240

ccagcctcgg aacctgagcg cccttctgcc tggaaagttt gtggctaggc gccatggcca    300

agagcagctc cctgaatgtt cgcgtggtgg agggccgcgc gctgcctgcc aaggacgtgt    360

ctgggagcag cgacccctac tgcctagtga aagtggacga cgaggtggtg gccaggacag    420

ctactgtctg gaggagcctg ggccccttct ggggggagga gtacacggtg cacctgcctc    480

tggatttcca ccagctggcc ttctacgtgc tggatgagga cactgtcggg cacgacgaca    540

tcatcggcaa gatctcgctg agcagggagg cgattacagc cgacccccga gggattgaca    600

gctggattaa cttgagccga gtggacccag atgcagaagt gcagggtgag atctgcctgt    660

cagtgcagat gctggaggat gggcagggcc gctgccttcg ctgccatgtg cttcacgcca    720

gggacctggc tcccagagac atctctggca catctgaccc atttgcacgt gtgttttggg    780

gcagccagag cttggagacc tcaaccatca agaagactcg cttcccgcac tgggatgaag    840

tgctggagct gcgggagatg ccaggtgccc cgtccccact gcgggtggag ctctgggact    900

gggacatggt gggcaagaat gacttcttgg gcatggtgga gttctctcca aagaccctcc    960

agcagaagcc acctaaaggc tggttccgcc tcctgccctt tcccagagcc gaggaggatt   1020

ctggggggaa cctgggtgcc ctgcgagtga aggtacgcct gattgaggac cgcgtcctgc   1080

cctcccagtg ctaccagcct ctcatggagc tgctcatgga gtctgtgcag gggccagcag   1140

aggaggacac tgctagcccc ttggctttgc tggaagagct gaccttgggg gactgccgcc   1200

aggaccttgc caccaagctg gtgaaactct ttcttggccg gggactggct gggcactttc   1260

tggactatct cacccggcgt gaggtggctc ggaccatgga ccccaacacc ctcttccgtt   1320

ctaactccct ggcatccaag tcgatggaac agtttatgaa gctcgtgggc atgccctacc   1380

tgcacgaggt cctgaagcct gtgattagcc gtgtctttga ggagaagaag tacatggagc   1440

tggatccctg caagatggac ctgggccgca cccggaggat ctccttcaaa ggcgcactct   1500

cggaggagca gatgcgggag accagcctgg ggctgctgac gggctacctg gggcccatcg   1560

tggacgccat cgtgggctcc gtggggcgct gcccgcccgc catgcgcctc gccttcaagc   1620

agctgcaccg gcgagtggag gagcgcttcc cccaggccga gcaccaggat gtgaagtacc   1680

tggccatcag tggatttctc ttcttgcgat tcttcgcacc tgccatcctt accccaaagc   1740

tgtttgacct tcgggaccaa cacgcggacc cccagactag ccgctcactg ctgttgcttg   1800

ccaaggctgt gcagagcatt ggaaacctgg gccagcagct gggccaaggc aaggaactgt   1860

ggatggcccc cctgcacccc ttcctgctgc agtgtgtctc acgtgtgaga gacttcctgg   1920

accggctggt ggatgtggat ggggatgaag ctggtgtccc agccagggcc ctgttcccgc   1980

cctcggccat tgttcgagaa ggctatctgc tgaagcgcaa ggaggagcct gccggcctgg   2040

ccacgcgctt tgccttcaag aagcgctacg tctggctcag cggggagacc ctctccttct   2100

ccaagagtcc tgagtggcag atgtgtcact ccatccccgt gtctcacatc cgcgccgtgg   2160

agcgcgtaga cgagggcgcc ttccaactgc cccacgtgat gcaggtggtg acgcaggacg   2220

gcacgggggc gctgcacacc acctacctcc agtgcaagaa tgtgaatgag ctcaaccagt   2280

ggctctcggc cttgcgcaag gccagcgccc ccaacccgaa caagctggcc gcctgccacc   2340

ccggtgcctt ccgcagcgcg cgctggacct gctgcctcca ggctgagcgc tcagccgccg   2400

gctgcagccg tacacactca gctgtcaccc tgggggactg gagtgaccca ctggatcctg   2460

atgctgaggc ccagacagtg tatcggcagc tgctcctggg gcgggaccag ctcaggctga   2520

aattactgga ggattctaac atggatacaa ctctggaggc agacacaggg gcctgtcctg   2580

aggtcctggc ccggcaaaga gcagcaactg cccgcctgct ggaggtgctc gcagacctgg   2640

atcgtgccca cgaggagttc cagcagcagg agcgagggaa ggcggccctg ggcccccttg   2700

gcccctaagg aaatgccaga gctagcccgg aaggaggagc aagagccagg gggccctctt   2760

cagcgcatcc tgccccggga gtctcctgtc tccttggacc tctttgattc tgtggtttgg   2820

aggctcccag agacgtgcct agtcctgtgt gccttgagtc cagaactcag ggcatggaag   2880

ccctttggca ggggccagcc ttgcactgag tgaaacttgc cctctggctt gattcagact   2940

ggagtggata ggataaggaa cctgacttat ttgactgaga ctggggtctc tacttcacca   3000

aactggcctc tatccatacc aaggaggcca gcctggccct gagctgctgg atacagctgg   3060

acctgaattc ctgatgccca tgtgatgttg ttgccccaga tgggcactaa atggcctcac   3120

tcctaaaaaa aaaaaaaaaa aaaaaaaa                                      3148


<210>  3023
<211>  804
<212>  PRT
<213>  Homosapiens

<400>  3023

Met Ala Lys Ser Ser Ser Leu Asn Val Arg Val Val Glu Gly Arg Ala 
1               5                   10                  15      


Leu Pro Ala Lys Asp Val Ser Gly Ser Ser Asp Pro Tyr Cys Leu Val 
            20                  25                  30          


Lys Val Asp Asp Glu Val Val Ala Arg Thr Ala Thr Val Trp Arg Ser 
        35                  40                  45              


Leu Gly Pro Phe Trp Gly Glu Glu Tyr Thr Val His Leu Pro Leu Asp 
    50                  55                  60                  


Phe His Gln Leu Ala Phe Tyr Val Leu Asp Glu Asp Thr Val Gly His 
65                  70                  75                  80  


Asp Asp Ile Ile Gly Lys Ile Ser Leu Ser Arg Glu Ala Ile Thr Ala 
                85                  90                  95      


Asp Pro Arg Gly Ile Asp Ser Trp Ile Asn Leu Ser Arg Val Asp Pro 
            100                 105                 110         


Asp Ala Glu Val Gln Gly Glu Ile Cys Leu Ser Val Gln Met Leu Glu 
        115                 120                 125             


Asp Gly Gln Gly Arg Cys Leu Arg Cys His Val Leu His Ala Arg Asp 
    130                 135                 140                 


Leu Ala Pro Arg Asp Ile Ser Gly Thr Ser Asp Pro Phe Ala Arg Val 
145                 150                 155                 160 


Phe Trp Gly Ser Gln Ser Leu Glu Thr Ser Thr Ile Lys Lys Thr Arg 
                165                 170                 175     


Phe Pro His Trp Asp Glu Val Leu Glu Leu Arg Glu Met Pro Gly Ala 
            180                 185                 190         


Pro Ser Pro Leu Arg Val Glu Leu Trp Asp Trp Asp Met Val Gly Lys 
        195                 200                 205             


Asn Asp Phe Leu Gly Met Val Glu Phe Ser Pro Lys Thr Leu Gln Gln 
    210                 215                 220                 


Lys Pro Pro Lys Gly Trp Phe Arg Leu Leu Pro Phe Pro Arg Ala Glu 
225                 230                 235                 240 


Glu Asp Ser Gly Gly Asn Leu Gly Ala Leu Arg Val Lys Val Arg Leu 
                245                 250                 255     


Ile Glu Asp Arg Val Leu Pro Ser Gln Cys Tyr Gln Pro Leu Met Glu 
            260                 265                 270         


Leu Leu Met Glu Ser Val Gln Gly Pro Ala Glu Glu Asp Thr Ala Ser 
        275                 280                 285             


Pro Leu Ala Leu Leu Glu Glu Leu Thr Leu Gly Asp Cys Arg Gln Asp 
    290                 295                 300                 


Leu Ala Thr Lys Leu Val Lys Leu Phe Leu Gly Arg Gly Leu Ala Gly 
305                 310                 315                 320 


His Phe Leu Asp Tyr Leu Thr Arg Arg Glu Val Ala Arg Thr Met Asp 
                325                 330                 335     


Pro Asn Thr Leu Phe Arg Ser Asn Ser Leu Ala Ser Lys Ser Met Glu 
            340                 345                 350         


Gln Phe Met Lys Leu Val Gly Met Pro Tyr Leu His Glu Val Leu Lys 
        355                 360                 365             


Pro Val Ile Ser Arg Val Phe Glu Glu Lys Lys Tyr Met Glu Leu Asp 
    370                 375                 380                 


Pro Cys Lys Met Asp Leu Gly Arg Thr Arg Arg Ile Ser Phe Lys Gly 
385                 390                 395                 400 


Ala Leu Ser Glu Glu Gln Met Arg Glu Thr Ser Leu Gly Leu Leu Thr 
                405                 410                 415     


Gly Tyr Leu Gly Pro Ile Val Asp Ala Ile Val Gly Ser Val Gly Arg 
            420                 425                 430         


Cys Pro Pro Ala Met Arg Leu Ala Phe Lys Gln Leu His Arg Arg Val 
        435                 440                 445             


Glu Glu Arg Phe Pro Gln Ala Glu His Gln Asp Val Lys Tyr Leu Ala 
    450                 455                 460                 


Ile Ser Gly Phe Leu Phe Leu Arg Phe Phe Ala Pro Ala Ile Leu Thr 
465                 470                 475                 480 


Pro Lys Leu Phe Asp Leu Arg Asp Gln His Ala Asp Pro Gln Thr Ser 
                485                 490                 495     


Arg Ser Leu Leu Leu Leu Ala Lys Ala Val Gln Ser Ile Gly Asn Leu 
            500                 505                 510         


Gly Gln Gln Leu Gly Gln Gly Lys Glu Leu Trp Met Ala Pro Leu His 
        515                 520                 525             


Pro Phe Leu Leu Gln Cys Val Ser Arg Val Arg Asp Phe Leu Asp Arg 
    530                 535                 540                 


Leu Val Asp Val Asp Gly Asp Glu Ala Gly Val Pro Ala Arg Ala Leu 
545                 550                 555                 560 


Phe Pro Pro Ser Ala Ile Val Arg Glu Gly Tyr Leu Leu Lys Arg Lys 
                565                 570                 575     


Glu Glu Pro Ala Gly Leu Ala Thr Arg Phe Ala Phe Lys Lys Arg Tyr 
            580                 585                 590         


Val Trp Leu Ser Gly Glu Thr Leu Ser Phe Ser Lys Ser Pro Glu Trp 
        595                 600                 605             


Gln Met Cys His Ser Ile Pro Val Ser His Ile Arg Ala Val Glu Arg 
    610                 615                 620                 


Val Asp Glu Gly Ala Phe Gln Leu Pro His Val Met Gln Val Val Thr 
625                 630                 635                 640 


Gln Asp Gly Thr Gly Ala Leu His Thr Thr Tyr Leu Gln Cys Lys Asn 
                645                 650                 655     


Val Asn Glu Leu Asn Gln Trp Leu Ser Ala Leu Arg Lys Ala Ser Ala 
            660                 665                 670         


Pro Asn Pro Asn Lys Leu Ala Ala Cys His Pro Gly Ala Phe Arg Ser 
        675                 680                 685             


Ala Arg Trp Thr Cys Cys Leu Gln Ala Glu Arg Ser Ala Ala Gly Cys 
    690                 695                 700                 


Ser Arg Thr His Ser Ala Val Thr Leu Gly Asp Trp Ser Asp Pro Leu 
705                 710                 715                 720 


Asp Pro Asp Ala Glu Ala Gln Thr Val Tyr Arg Gln Leu Leu Leu Gly 
                725                 730                 735     


Arg Asp Gln Leu Arg Leu Lys Leu Leu Glu Asp Ser Asn Met Asp Thr 
            740                 745                 750         


Thr Leu Glu Ala Asp Thr Gly Ala Cys Pro Glu Val Leu Ala Arg Gln 
        755                 760                 765             


Arg Ala Ala Thr Ala Arg Leu Leu Glu Val Leu Ala Asp Leu Asp Arg 
    770                 775                 780                 


Ala His Glu Glu Phe Gln Gln Gln Glu Arg Gly Lys Ala Ala Leu Gly 
785                 790                 795                 800 


Pro Leu Gly Pro 
                


<210>  3024
<211>  918
<212>  DNA
<213>  Homosapiens

<400>  3024
atggcggtgc cctgggagga atatttccga ctggctttgc aagagaaact gtctacaaag     60

ctgccagagc aggctgagga tcatgtccca ccagtactgc gtctcctgga gaagaggcaa    120

gagctggtag atgcagacca ggccctgcag gcccagaagg aggtgttccg caccaagacg    180

gcagccctga aacagcgttg ggaacagctg gaacaaaagg agcgggagct aaagggatcg    240

ttcatccgct ttgacaagtt tttgcaggac tccgaggccc ggcgcaatcg cgcgctgcgg    300

agggcggcgg aggagaggca ccaggcgggc cgtcgggagg tggaggcgct gcgtctgtgg    360

acccagctcc aggagctacg gcgggaacac gcgcggctgc agcgccggct taagcgcctg    420

gagccctgcg cgcgcctgct ggagcaagcg ctggagctgc tgcccgggtt ccaagaggtt    480

ccggagctgg tggcgcgctt cgacggcctg gccgagacgc aggcggcgct gaggctcagg    540

gagcgcgagc agctcgcgga gctggaggcg gcgcgagcgc ggctgcagca gctgcgggac    600

gcctggccgg acgaggtgct cgcacagggc cagcggcggg cacagctgca ggagcgcctg    660

gaggctgcca gggagcgtac gctgcagtgg gaatccaagt ggattcagat tcagaacaca    720

gcagcggaga agactctgct cctgggacgc agcaggatgg ctgtgctcaa cctgttccag    780

ctagtgtgcc agcatcaggg gcagcctccc accctggaca tcgaggacac ggagggacag    840

ctagagcacg accagaccat ctcttttcaa aatcaactct ctgcccgtca aggagaaagg    900

ctccacggag ggacatga                                                  918


<210>  3025
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  3025

Met Ala Val Pro Trp Glu Glu Tyr Phe Arg Leu Ala Leu Gln Glu Lys 
1               5                   10                  15      


Leu Ser Thr Lys Leu Pro Glu Gln Ala Glu Asp His Val Pro Pro Val 
            20                  25                  30          


Leu Arg Leu Leu Glu Lys Arg Gln Glu Leu Val Asp Ala Asp Gln Ala 
        35                  40                  45              


Leu Gln Ala Gln Lys Glu Val Phe Arg Thr Lys Thr Ala Ala Leu Lys 
    50                  55                  60                  


Gln Arg Trp Glu Gln Leu Glu Gln Lys Glu Arg Glu Leu Lys Gly Ser 
65                  70                  75                  80  


Phe Ile Arg Phe Asp Lys Phe Leu Gln Asp Ser Glu Ala Arg Arg Asn 
                85                  90                  95      


Arg Ala Leu Arg Arg Ala Ala Glu Glu Arg His Gln Ala Gly Arg Arg 
            100                 105                 110         


Glu Val Glu Ala Leu Arg Leu Trp Thr Gln Leu Gln Glu Leu Arg Arg 
        115                 120                 125             


Glu His Ala Arg Leu Gln Arg Arg Leu Lys Arg Leu Glu Pro Cys Ala 
    130                 135                 140                 


Arg Leu Leu Glu Gln Ala Leu Glu Leu Leu Pro Gly Phe Gln Glu Val 
145                 150                 155                 160 


Pro Glu Leu Val Ala Arg Phe Asp Gly Leu Ala Glu Thr Gln Ala Ala 
                165                 170                 175     


Leu Arg Leu Arg Glu Arg Glu Gln Leu Ala Glu Leu Glu Ala Ala Arg 
            180                 185                 190         


Ala Arg Leu Gln Gln Leu Arg Asp Ala Trp Pro Asp Glu Val Leu Ala 
        195                 200                 205             


Gln Gly Gln Arg Arg Ala Gln Leu Gln Glu Arg Leu Glu Ala Ala Arg 
    210                 215                 220                 


Glu Arg Thr Leu Gln Trp Glu Ser Lys Trp Ile Gln Ile Gln Asn Thr 
225                 230                 235                 240 


Ala Ala Glu Lys Thr Leu Leu Leu Gly Arg Ser Arg Met Ala Val Leu 
                245                 250                 255     


Asn Leu Phe Gln Leu Val Cys Gln His Gln Gly Gln Pro Pro Thr Leu 
            260                 265                 270         


Asp Ile Glu Asp Thr Glu Gly Gln Leu Glu His Asp Gln Thr Ile Ser 
        275                 280                 285             


Phe Gln Asn Gln Leu Ser Ala Arg Gln Gly Glu Arg Leu His Gly Gly 
    290                 295                 300                 


Thr 
305 


<210>  3026
<211>  4401
<212>  DNA
<213>  Homosapiens

<400>  3026
ccttctgcgt tcccagcgcg cggcccgaat ggcggccgac aagggcccgg cggctggacc     60

tcggtcgcga gctgccatgg cccagtggag gaagaagaaa gggctccgga agcgccgagg    120

cgcggcctcc caggcccgcg gcagcgactc ggaggacggc gagtttgaga tccaggcgga    180

agatgacgcc cgggcccgga agctgggacc tggaagaccc ctgcccacct tccccacctc    240

ggaatgcacc tcggatgtgg agccggacac ccgggagatg gtgcgtgccc agaacaagaa    300

gaagaagaag tctggaggct tccagtccat gggcctgagc tacccggtgt tcaaaggcat    360

catgaagaag gggtacaagg tgccaacacc catccagagg aagaccatcc cggtgatctt    420

ggatggcaag gacgtggtgg ccatggcccg gacgggcagt ggcaagacag cctgcttcct    480

cctcccaatg ttcgagcggc tcaagaccca cagtgcccag accggggccc gcgccctcat    540

cctctcgccg acccgagagc tggccctgca gaccctgaag ttcactaagg agctaggcaa    600

gttcactggc ctcaagactg ccctgatcct gggtggagac aggatggaag accagtttgc    660

agccctgcac gaaaatcccg acataattat tgccacgccc ggacggttgg tgcatgtggc    720

tgtggaaatg agcctgaagc tgcagagtgt ggaatacgtg gtgttcgatg aagctgaccg    780

gctttttgaa atgggtttcg cagagcagct gcaggagatc atcgcccgcc tccccggggg    840

ccaccagacg gtgctgttct ccgccacgct gcccaaactg ctggtggaat ttgcccgggc    900

tggcctcacg gagcccgtgc tcatccggct tgacgtggat accaagctca acgagcagct    960

gaagacctcc ttcttcctcg tgcgggagga caccaaggct gccgtgctgc tccacctgct   1020

gcacaacgtg gtgcggcccc aggaccagac cgtggtgttt gtggccacga agcaccacgc   1080

cgagtacctc actgagctgc tgacgaccca gcgggtgagc tgcgcccaca tctacagtgc   1140

cctagacccg acagcccgca agatcaatct cgccaaattc acgcttggca agtgctccac   1200

tctcattgtg actgacctgg ccgcccgagg cctggacatc ccgctgctgg acaatgtcat   1260

caactacagc ttccccgcca agggcaaact cttcctgcac cgcgtgggcc gtgtggctcg   1320

ggctggccga agtggcacag cctactcctt ggtggcccct gatgaaatcc cctacctgct   1380

ggatctgcac ctgttcctgg gccgctccct caccctcgcc cgacccctca aggagccctc   1440

aggtgtggcc ggtgtggatg gcatgctggg tcgggtgcca cagagtgtgg tggacgagga   1500

ggacagtggt ctgcagagca ccctggaggc atcgctggag ctacggggcc tggcccgcgt   1560

tgctgataac gcccagcagc agtatgtgcg ctcacgcccg gcgccctcgc ctgagtccat   1620

caagagggcc aaggagatgg accttgtggg gctgggcctg caccccctct tcagctcgcg   1680

ttttgaggag gaggagctgc agcggctgag gctggtggac agcataaaga actaccgctc   1740

ccgggcgact atctttgaga tcaacgcctc cagccgagac ctgtgcagcc aggtgatgcg   1800

cgccaagcgg cagaaggacc gcaaggccat cgcccgcttc cagcagggac agcaggggcg   1860

gcaggagcag caggagggcc cagtgggccc agccccgagc cgcccagcac tgcaggagaa   1920

gcagcctgag aaggaggagg aggaggaggc gggagagagt gtggaggaca ttttctcaga   1980

ggtcgtgggc cggaagcggc agcggtcagg acccaacagg ggagccaaga ggcggaggga   2040

ggaggcccgg cagcgggacc aggaattcta catcccctac cggcccaagg actttgacag   2100

cgagcggggc ctgagcatca gcggggaagg gggagccttt gagcagcagg cagctggcgc   2160

tgtcctggac ttgatggggg atgaagccca gaacctgacg aggggccggc agcagctcaa   2220

gtgggaccgt aagaagaagc ggtttgtggg acagtcagga caggaagaca agaagaagat   2280

taagacagag agcggccgct acatcagcag ctcctacaag cgagacctct atcagaagtg   2340

gaaacagaaa cagaaaattg atgatcgtga ctcggacgaa gaaggggcat ctgaccggcg   2400

aggcccagag cgaagaggtg ggaagcgaga ccgtggccaa ggtgcatccc ggccccacgc   2460

cccaggcacc cctgcaggcc gagtccgccc ggaactcaag accaagcagc agatcctgaa   2520

gcagcggcgc cgggcccaga agctgcactt cctgcagcgt ggtggcctca agcagctctc   2580

tgcccgcaac cgccgccgcg tccaggagct gcagcagggc gccttcggcc ggggtgcccg   2640

ctccaagaag ggcaagatgc ggaagaggat gtgaggacca ggacccagcc ccgtggctcc   2700

ttgattggcc ttagggtggg catcagcaga cgttcccgtg caccactgtg tgcctggccc   2760

tgtgctgggc actgggggca ctccctgcag gagccatcat ctgtgaaaag gagcactgta   2820

tggccacaga agggcagcag ctgcgtcagc ctaagacaga gacatttgaa cagggccttg   2880

aagggtgtgc aggagttcgc cagcaaagcc aggcaggcca agacttgagt tggcaactca   2940

gctgctgctg cttccatgtg ttctgggttc agaggtcatg gctgcaccgg tcagagccct   3000

gagtgcctca gggtttggca atggaatttt taatgtaata aatctttatt gagcactgct   3060

ggtggccagg agtgcggtct acttggggaa ctggaatgga gagacccagg tactaaaatc   3120

ccagctaacg tggcagagga gttgcgggtc tcctgagggt gagttctgct gccttgtcca   3180

tttagcgatg aggaaagtga agctcagagc acaaaccagg tgccagaggc gggagttggt   3240

cccccttcct cccactggac atggttgcag ctgggagtgg gctgggggag gggaacagga   3300

tgcccagccc agggggcaag gacacagctg ctcccctctg gctatgaaga ggttaacgcg   3360

gcccctccac acctggaggt cagaacctgg cctgtcctct gtcttcttgc cacccacccc   3420

ctgtttgagg ttctgagaag gtcaagggca gccccagcag ctggattctc aggctgggcc   3480

cctcacctgg cagagtccat agtggagggg gccttggtga tctctcatct agcatggacc   3540

ctgttctgag acctgacaaa gagttttttt tcatgcccca accaccctgg cagggagggc   3600

ctggtctgat ctcattttag aggcagttgc cccacacata gccccttgac cttcccatca   3660

cctcctcatc agggcctgca tttatggagt gcttgctatg tgcccctcat ggcaggccca   3720

cagcactctg aacaggcaca gccctcccat cttcccaatg aggaaacgga ttcaggaaga   3780

gccactcagt ccacacccca ttggaaatgt gggccctcct atctcagggt ctctcagggg   3840

ttccctctcc cgctgctcac ctgtgtcagg gctaggaggc aggggctgca ggctcagcct   3900

gacccaggcc ggccagcatg gcagagaggt cctgcatgaa cagcttcacc tgggggggcc   3960

cagcacgaag tcacatccca gccccagagt cactgtccag cccccacccc tcaacacgcg   4020

ggggaggccg aaaggtaggg cggggactgg agatcccctc attaaaagaa cagtgatgat   4080

ggtggttccc agaggtggtg actgagatcc taaaccgttc tgggttttga aagcctcagg   4140

ccaaccttcc caactgctgc gtgagcagac accttcacag cttcctcgct gctgtcacct   4200

gcactatcca attagtattt tcatttacat caatcagctt tattttcttg taactggatc   4260

agtcatattc attggtttgt gacctactct tatctccgtg ggtggctctc cttttgtttt   4320

aattaacttc tttatgaata tgaacttaat aaataccatg gatccattgt aaaaactaaa   4380

aaaaaaaaaa aaaaaaaaaa a                                             4401


<210>  3027
<211>  881
<212>  PRT
<213>  Homosapiens

<400>  3027

Met Ala Ala Asp Lys Gly Pro Ala Ala Gly Pro Arg Ser Arg Ala Ala 
1               5                   10                  15      


Met Ala Gln Trp Arg Lys Lys Lys Gly Leu Arg Lys Arg Arg Gly Ala 
            20                  25                  30          


Ala Ser Gln Ala Arg Gly Ser Asp Ser Glu Asp Gly Glu Phe Glu Ile 
        35                  40                  45              


Gln Ala Glu Asp Asp Ala Arg Ala Arg Lys Leu Gly Pro Gly Arg Pro 
    50                  55                  60                  


Leu Pro Thr Phe Pro Thr Ser Glu Cys Thr Ser Asp Val Glu Pro Asp 
65                  70                  75                  80  


Thr Arg Glu Met Val Arg Ala Gln Asn Lys Lys Lys Lys Lys Ser Gly 
                85                  90                  95      


Gly Phe Gln Ser Met Gly Leu Ser Tyr Pro Val Phe Lys Gly Ile Met 
            100                 105                 110         


Lys Lys Gly Tyr Lys Val Pro Thr Pro Ile Gln Arg Lys Thr Ile Pro 
        115                 120                 125             


Val Ile Leu Asp Gly Lys Asp Val Val Ala Met Ala Arg Thr Gly Ser 
    130                 135                 140                 


Gly Lys Thr Ala Cys Phe Leu Leu Pro Met Phe Glu Arg Leu Lys Thr 
145                 150                 155                 160 


His Ser Ala Gln Thr Gly Ala Arg Ala Leu Ile Leu Ser Pro Thr Arg 
                165                 170                 175     


Glu Leu Ala Leu Gln Thr Leu Lys Phe Thr Lys Glu Leu Gly Lys Phe 
            180                 185                 190         


Thr Gly Leu Lys Thr Ala Leu Ile Leu Gly Gly Asp Arg Met Glu Asp 
        195                 200                 205             


Gln Phe Ala Ala Leu His Glu Asn Pro Asp Ile Ile Ile Ala Thr Pro 
    210                 215                 220                 


Gly Arg Leu Val His Val Ala Val Glu Met Ser Leu Lys Leu Gln Ser 
225                 230                 235                 240 


Val Glu Tyr Val Val Phe Asp Glu Ala Asp Arg Leu Phe Glu Met Gly 
                245                 250                 255     


Phe Ala Glu Gln Leu Gln Glu Ile Ile Ala Arg Leu Pro Gly Gly His 
            260                 265                 270         


Gln Thr Val Leu Phe Ser Ala Thr Leu Pro Lys Leu Leu Val Glu Phe 
        275                 280                 285             


Ala Arg Ala Gly Leu Thr Glu Pro Val Leu Ile Arg Leu Asp Val Asp 
    290                 295                 300                 


Thr Lys Leu Asn Glu Gln Leu Lys Thr Ser Phe Phe Leu Val Arg Glu 
305                 310                 315                 320 


Asp Thr Lys Ala Ala Val Leu Leu His Leu Leu His Asn Val Val Arg 
                325                 330                 335     


Pro Gln Asp Gln Thr Val Val Phe Val Ala Thr Lys His His Ala Glu 
            340                 345                 350         


Tyr Leu Thr Glu Leu Leu Thr Thr Gln Arg Val Ser Cys Ala His Ile 
        355                 360                 365             


Tyr Ser Ala Leu Asp Pro Thr Ala Arg Lys Ile Asn Leu Ala Lys Phe 
    370                 375                 380                 


Thr Leu Gly Lys Cys Ser Thr Leu Ile Val Thr Asp Leu Ala Ala Arg 
385                 390                 395                 400 


Gly Leu Asp Ile Pro Leu Leu Asp Asn Val Ile Asn Tyr Ser Phe Pro 
                405                 410                 415     


Ala Lys Gly Lys Leu Phe Leu His Arg Val Gly Arg Val Ala Arg Ala 
            420                 425                 430         


Gly Arg Ser Gly Thr Ala Tyr Ser Leu Val Ala Pro Asp Glu Ile Pro 
        435                 440                 445             


Tyr Leu Leu Asp Leu His Leu Phe Leu Gly Arg Ser Leu Thr Leu Ala 
    450                 455                 460                 


Arg Pro Leu Lys Glu Pro Ser Gly Val Ala Gly Val Asp Gly Met Leu 
465                 470                 475                 480 


Gly Arg Val Pro Gln Ser Val Val Asp Glu Glu Asp Ser Gly Leu Gln 
                485                 490                 495     


Ser Thr Leu Glu Ala Ser Leu Glu Leu Arg Gly Leu Ala Arg Val Ala 
            500                 505                 510         


Asp Asn Ala Gln Gln Gln Tyr Val Arg Ser Arg Pro Ala Pro Ser Pro 
        515                 520                 525             


Glu Ser Ile Lys Arg Ala Lys Glu Met Asp Leu Val Gly Leu Gly Leu 
    530                 535                 540                 


His Pro Leu Phe Ser Ser Arg Phe Glu Glu Glu Glu Leu Gln Arg Leu 
545                 550                 555                 560 


Arg Leu Val Asp Ser Ile Lys Asn Tyr Arg Ser Arg Ala Thr Ile Phe 
                565                 570                 575     


Glu Ile Asn Ala Ser Ser Arg Asp Leu Cys Ser Gln Val Met Arg Ala 
            580                 585                 590         


Lys Arg Gln Lys Asp Arg Lys Ala Ile Ala Arg Phe Gln Gln Gly Gln 
        595                 600                 605             


Gln Gly Arg Gln Glu Gln Gln Glu Gly Pro Val Gly Pro Ala Pro Ser 
    610                 615                 620                 


Arg Pro Ala Leu Gln Glu Lys Gln Pro Glu Lys Glu Glu Glu Glu Glu 
625                 630                 635                 640 


Ala Gly Glu Ser Val Glu Asp Ile Phe Ser Glu Val Val Gly Arg Lys 
                645                 650                 655     


Arg Gln Arg Ser Gly Pro Asn Arg Gly Ala Lys Arg Arg Arg Glu Glu 
            660                 665                 670         


Ala Arg Gln Arg Asp Gln Glu Phe Tyr Ile Pro Tyr Arg Pro Lys Asp 
        675                 680                 685             


Phe Asp Ser Glu Arg Gly Leu Ser Ile Ser Gly Glu Gly Gly Ala Phe 
    690                 695                 700                 


Glu Gln Gln Ala Ala Gly Ala Val Leu Asp Leu Met Gly Asp Glu Ala 
705                 710                 715                 720 


Gln Asn Leu Thr Arg Gly Arg Gln Gln Leu Lys Trp Asp Arg Lys Lys 
                725                 730                 735     


Lys Arg Phe Val Gly Gln Ser Gly Gln Glu Asp Lys Lys Lys Ile Lys 
            740                 745                 750         


Thr Glu Ser Gly Arg Tyr Ile Ser Ser Ser Tyr Lys Arg Asp Leu Tyr 
        755                 760                 765             


Gln Lys Trp Lys Gln Lys Gln Lys Ile Asp Asp Arg Asp Ser Asp Glu 
    770                 775                 780                 


Glu Gly Ala Ser Asp Arg Arg Gly Pro Glu Arg Arg Gly Gly Lys Arg 
785                 790                 795                 800 


Asp Arg Gly Gln Gly Ala Ser Arg Pro His Ala Pro Gly Thr Pro Ala 
                805                 810                 815     


Gly Arg Val Arg Pro Glu Leu Lys Thr Lys Gln Gln Ile Leu Lys Gln 
            820                 825                 830         


Arg Arg Arg Ala Gln Lys Leu His Phe Leu Gln Arg Gly Gly Leu Lys 
        835                 840                 845             


Gln Leu Ser Ala Arg Asn Arg Arg Arg Val Gln Glu Leu Gln Gln Gly 
    850                 855                 860                 


Ala Phe Gly Arg Gly Ala Arg Ser Lys Lys Gly Lys Met Arg Lys Arg 
865                 870                 875                 880 


Met 
    


<210>  3028
<211>  1775
<212>  DNA
<213>  Homosapiens

<400>  3028
gtgcaaagtg ctgggttctg ggtttctgga ttcgcgggcc gttcacacgt agcctgtgcc     60

ggctcctcgg gtgagtccgt ccgcgcgcgg tgccccggga cggcctaggc tgccgggggt    120

ccggggcccc aggcattccg ggctgcagat tgacggggat cccggatgca ccgcgcgccc    180

ccgcgccctc accgacgggt ccagacctgg tgggaagaag gtgcggggac gggtccctga    240

ggatcccgat gcctacgagc caagatgctc agctttatag gtgtgaccta cacatgtgac    300

ttcacctcag ttttgtgatc cgtaaaatgg acaaattcga agctacttca cagtgctgtt    360

gagaggatta aatgaaacaa tgcttgtaaa gctctttgca ggagggagcc tcggaagcag    420

ggcctggccg gcagagcaca cctgctgtca ccagggacca caggcagcat gaagaccccc    480

gtggagctgg ccgtcagtgg gatgcagacc ctcggccttc agcaccgctg ccgaggtggc    540

taccgggtca aggccaggac gtcatatgtg gatgagactc tgtttggcag cccagcaggc    600

acccggccta ccccaccgga cttcgatccg ccctgggtgg agaaggctaa cagaaccaga    660

ggcgtgggca aggaggcatc gaaggccttg ggggcaaagg ggagctgtga gaccaccccc    720

tcaaggggca gcacccccac cctcacacca aggaagaaga acaaatacag acccatcagc    780

cacaccccgt cttactgtga tgagtcgctg tttggctccc gatctgaagg cgccagcttc    840

ggggccccgc ggatggcgaa gggggatgcc gcaaagctcc gtgctctctt gtggacgcca    900

ccacctaccc ccaggggtag ccactcgccc cgccccaggg aggcaccact gcgagccatt    960

cacccagctg gtccctccaa gacagagccg gggccagcgg cagactccca gaagttatct   1020

atgggtgggt tacactcttc acgccccctg aagcggggac tttcccattc cctcacccac   1080

ctgaatgtcc ccagcactgg tcatccagcc accagtgccc cccacacaaa tgggcctcag   1140

gatctcaggc cttccacgtc aggggtgacc ttccggagcc ccctggtgac ttccagggct   1200

cgctcagtta gcatttcagt gccatctacc ccacgacgag gtggggccac ccagaaacca   1260

aagccccctt ggaaatgata ctctttcatc agggttgcct atggggccac ggcgacaggt   1320

atggcccctt gccagggtag gaggacattc atcacccagg gaaccccagg tattaaagaa   1380

gcccctgtgg gggcagacag acatagcagg ggtgggcagt gcctcccttt atcctgacaa   1440

tctctagtcg attcttgcct ttttctcccg attgcggatt tgggggccac ctctaagatg   1500

cctctctcca gccctgtctc aaccatactc caaattagtg ccaacccagg ggcctggcac   1560

ctcccacatc atccattgtc ttgctgccaa gtgcgaataa acggcgtgat tgccaacctg   1620

gagggtcccc tcttatccct tcaagccaag cttcctgctc aggattagtt tccagctaag   1680

tctgcaagcc ctagaggagt ttttccaggc tgtctgtgaa gcctggggaa cacaacggca   1740

actgggagat ttgtgagtga acactgtttc atctt                              1775


<210>  3029
<211>  269
<212>  PRT
<213>  Homosapiens

<400>  3029

Met Lys Thr Pro Val Glu Leu Ala Val Ser Gly Met Gln Thr Leu Gly 
1               5                   10                  15      


Leu Gln His Arg Cys Arg Gly Gly Tyr Arg Val Lys Ala Arg Thr Ser 
            20                  25                  30          


Tyr Val Asp Glu Thr Leu Phe Gly Ser Pro Ala Gly Thr Arg Pro Thr 
        35                  40                  45              


Pro Pro Asp Phe Asp Pro Pro Trp Val Glu Lys Ala Asn Arg Thr Arg 
    50                  55                  60                  


Gly Val Gly Lys Glu Ala Ser Lys Ala Leu Gly Ala Lys Gly Ser Cys 
65                  70                  75                  80  


Glu Thr Thr Pro Ser Arg Gly Ser Thr Pro Thr Leu Thr Pro Arg Lys 
                85                  90                  95      


Lys Asn Lys Tyr Arg Pro Ile Ser His Thr Pro Ser Tyr Cys Asp Glu 
            100                 105                 110         


Ser Leu Phe Gly Ser Arg Ser Glu Gly Ala Ser Phe Gly Ala Pro Arg 
        115                 120                 125             


Met Ala Lys Gly Asp Ala Ala Lys Leu Arg Ala Leu Leu Trp Thr Pro 
    130                 135                 140                 


Pro Pro Thr Pro Arg Gly Ser His Ser Pro Arg Pro Arg Glu Ala Pro 
145                 150                 155                 160 


Leu Arg Ala Ile His Pro Ala Gly Pro Ser Lys Thr Glu Pro Gly Pro 
                165                 170                 175     


Ala Ala Asp Ser Gln Lys Leu Ser Met Gly Gly Leu His Ser Ser Arg 
            180                 185                 190         


Pro Leu Lys Arg Gly Leu Ser His Ser Leu Thr His Leu Asn Val Pro 
        195                 200                 205             


Ser Thr Gly His Pro Ala Thr Ser Ala Pro His Thr Asn Gly Pro Gln 
    210                 215                 220                 


Asp Leu Arg Pro Ser Thr Ser Gly Val Thr Phe Arg Ser Pro Leu Val 
225                 230                 235                 240 


Thr Ser Arg Ala Arg Ser Val Ser Ile Ser Val Pro Ser Thr Pro Arg 
                245                 250                 255     


Arg Gly Gly Ala Thr Gln Lys Pro Lys Pro Pro Trp Lys 
            260                 265                 


<210>  3030
<211>  1363
<212>  DNA
<213>  Homosapiens

<400>  3030
ctgagattgg cgggtaacct agcaacgcag ggaccgcggc ggtaactgtg gctagggaaa     60

cctggagcgg tcagagcagg atggccagag acaataaaag cacgagaccc aagtagtcta    120

ccgaagtctc catctctgtg gacctacaga ggcacagagg gctgctcaca agatggcttt    180

agacattctc gccatggccc ctttgtatca ggcccctgcc atcaacagaa tagggccaaa    240

gacagaccca tctaaaaggc cagctgatcc actaaaaccc ttggttctct ctaggaccaa    300

actcaccacc attgaggcca aaaggatcat gtccatcctg gatgaggcga tctacaaggt    360

ggagctggtg accttgctgt cgtatgtggc atccaacaga gaggatatgg aggggatgct    420

gggggaggac gtcatgaggg cagtgagaga gcatgaggat ctctgccagg tcctccttga    480

aaacgtcagg tgcctgaaag agaaagaaag gcaattgcag gagcagaaag aggctgagga    540

ggaagggtgg ctcagagacc gcctcctttc catagagctg cagaaatcca gcctctcacc    600

acttatgcag cagatcaaag actccaccaa gaacgtcctt agactcttgc tcagcaaccc    660

ccaggctgct aggctcctgc agatgcagac acagggtaga agtgcagaag cccagaattt    720

tattgacagc ctgatagagc tccgtggttt cctgtttgaa aaactactca ctagtcccat    780

ggaagcgagg gataaggccc agttcttaca ggatatcagt agacagaata gtaataacca    840

acaaatcatt gatactcttg aaaaggaatt ggcggagaga atgaagaaca ggaatgcaga    900

ggaggagttg gaggatctgg acgctgttca cagggaggag aagatctcgc tggaggagct    960

caggcggagg cacaaagtgc tggtgggaga gtttgcgcag atccgggaag agcgggagat   1020

caactccaag aaaaggatgg aggcagagca ggagatggtg cgcatggtac gggcggccac   1080

gctcatccag gccctatgga agggctatct ggtgcgctcc ctgctcagat ccaagaagaa   1140

gcggggcaag ggcaaagcaa aggacaagga gaagggcaag cagaaaggca aggagaaggg   1200

caagggcaag aaatgagctc tccacccagc ccgctcctga cccttatctt cccagagacc   1260

aggccaggaa ggcccgagat ggagagcact aaattcacgg ctttcatgtt tttatttaat   1320

aaattaaaaa gtatttgaag ccacattgaa aaaaaaaaaa aaa                     1363


<210>  3031
<211>  347
<212>  PRT
<213>  Homosapiens

<400>  3031

Met Ala Leu Asp Ile Leu Ala Met Ala Pro Leu Tyr Gln Ala Pro Ala 
1               5                   10                  15      


Ile Asn Arg Ile Gly Pro Lys Thr Asp Pro Ser Lys Arg Pro Ala Asp 
            20                  25                  30          


Pro Leu Lys Pro Leu Val Leu Ser Arg Thr Lys Leu Thr Thr Ile Glu 
        35                  40                  45              


Ala Lys Arg Ile Met Ser Ile Leu Asp Glu Ala Ile Tyr Lys Val Glu 
    50                  55                  60                  


Leu Val Thr Leu Leu Ser Tyr Val Ala Ser Asn Arg Glu Asp Met Glu 
65                  70                  75                  80  


Gly Met Leu Gly Glu Asp Val Met Arg Ala Val Arg Glu His Glu Asp 
                85                  90                  95      


Leu Cys Gln Val Leu Leu Glu Asn Val Arg Cys Leu Lys Glu Lys Glu 
            100                 105                 110         


Arg Gln Leu Gln Glu Gln Lys Glu Ala Glu Glu Glu Gly Trp Leu Arg 
        115                 120                 125             


Asp Arg Leu Leu Ser Ile Glu Leu Gln Lys Ser Ser Leu Ser Pro Leu 
    130                 135                 140                 


Met Gln Gln Ile Lys Asp Ser Thr Lys Asn Val Leu Arg Leu Leu Leu 
145                 150                 155                 160 


Ser Asn Pro Gln Ala Ala Arg Leu Leu Gln Met Gln Thr Gln Gly Arg 
                165                 170                 175     


Ser Ala Glu Ala Gln Asn Phe Ile Asp Ser Leu Ile Glu Leu Arg Gly 
            180                 185                 190         


Phe Leu Phe Glu Lys Leu Leu Thr Ser Pro Met Glu Ala Arg Asp Lys 
        195                 200                 205             


Ala Gln Phe Leu Gln Asp Ile Ser Arg Gln Asn Ser Asn Asn Gln Gln 
    210                 215                 220                 


Ile Ile Asp Thr Leu Glu Lys Glu Leu Ala Glu Arg Met Lys Asn Arg 
225                 230                 235                 240 


Asn Ala Glu Glu Glu Leu Glu Asp Leu Asp Ala Val His Arg Glu Glu 
                245                 250                 255     


Lys Ile Ser Leu Glu Glu Leu Arg Arg Arg His Lys Val Leu Val Gly 
            260                 265                 270         


Glu Phe Ala Gln Ile Arg Glu Glu Arg Glu Ile Asn Ser Lys Lys Arg 
        275                 280                 285             


Met Glu Ala Glu Gln Glu Met Val Arg Met Val Arg Ala Ala Thr Leu 
    290                 295                 300                 


Ile Gln Ala Leu Trp Lys Gly Tyr Leu Val Arg Ser Leu Leu Arg Ser 
305                 310                 315                 320 


Lys Lys Lys Arg Gly Lys Gly Lys Ala Lys Asp Lys Glu Lys Gly Lys 
                325                 330                 335     


Gln Lys Gly Lys Glu Lys Gly Lys Gly Lys Lys 
            340                 345         


<210>  3032
<211>  2810
<212>  DNA
<213>  Homosapiens

<400>  3032
gagctggcgc agtgccctgg tggcagtggc tgaagtggcg gcggcttcgg cggctgcggc     60

gtctgcaaca gcttcgggct cggggttttg gcggcggcgc cggcgggcta ggctgcgcgg    120

tgcggacccc ggcgcgcggt ccgggttgct ggggcggcgc gtaagatgcc tctaatggag    180

gagtttctga gcagcacccc tggcccagtg gctttgaaag ggagctcaaa ccagagacta    240

tttcaagccc tggatatcat atcctgaggg ccacaggaga agagaacatg gctgtgagtt    300

tggatgacga cgtgccgctc atcctgacct tggatgaggg tggcagtgcc ccactggctc    360

cctccaacgg cctgggccaa gaagagctac ctagcaaaaa tggcggcagc tatgccatcc    420

acgactccca ggcccccagt ctcagctctg ggggtgagag ttccccctcc agccccgcac    480

acaactggga gatgaattac caagaggcag caatctacct ccaggaaggc gagaacaacg    540

acaagttctt cacccacccc aaggatgcca aggcgctggc ggcctacctc tttgcacaca    600

atcacctctt ctacctgatg gagctggcca cggccctgct gctgctgctg ctctccctgt    660

gcgaggcccc cgccgtcccc gcactccggc ttggcatcta tgtccacgcc accctggagc    720

tgtttgccct gatggtggta gtgtttgaac tctgcatgaa gttacgctgg ctgggcctcc    780

acaccttcat ccggcacaag cggaccatgg tcaagacctc ggtgctggtg gtgcagtttg    840

tcgaggccat cgtggtgttg gtacggcaga tgtcccatgt gcgggtgacc cgagcactgc    900

gctgcatttt cctggtggac tgtcggtatt gcggtggcgt ccggcgcaac ctgcggcaga    960

tcttccagtc cctgccgccc ttcatggaca tcctcctgct gctgctgttc ttcatgatca   1020

tctttgccat cctcggtttc tacttgttct cccctaaccc ttcagacccc tacttcagca   1080

ccctggagaa cagcatcgtc agtctgtttg tccttctgac cacagccaat ttcccagatg   1140

tgatgatgcc ctcctactcc cggaacccct ggtcctgcgt cttcttcatc gtgtacctct   1200

ccatcgagct gtatttcatc atgaacctgc ttctggctgt ggtgttcgac accttcaatg   1260

acattgagaa acgcaagttc aagtctttgc tactgcacaa gcgaaccgct atccagcatg   1320

cctaccgcct gctcatcagc cagaggaggc ctgccggcat ctcctacagg cagtttgaag   1380

gcctcatgcg cttctacaag ccccggatga gtgccaggga gcgctatctt accttcaagg   1440

ccctgaatca gaacaacaca cccctgctca gcctaaagga cttttacgat atctacgaag   1500

ttgctgcttt gaagtggaag gccaagaaaa acagagagca ctggtttgat gagcttccca   1560

ggacggcgct cctcatcttc aaaggtatta atatccttgt gaagtccaag gccttccagt   1620

atttcatgta cttggtggtg gcagtcaacg gggtctggat cctcgtggag acatttatgc   1680

tgaaaggtgg gaacttcttc tccaagcacg tgccctggag ttacctcgtc tttctaacta   1740

tctatggggt ggagctgttc ctgaaggttg ccggcctggg ccctgtggag tacttgtctt   1800

ccggatggaa cttgtttgac ttctccgtga cagtgttcgc cttcctggga ctgctggcgc   1860

tggccctcaa catggagccc ttctatttca tcgtggtcct gcgccccctc cagctgctga   1920

ggttgtttaa gttgaaggag cgctaccgca acgtgctgga caccatgttc gagctgctgc   1980

cccggatggc cagcctgggc ctcaccctgc tcatctttta ctactccttc gccatcgtgg   2040

gcatggagtt cttctgcggg atcgtcttcc ccaactgctg caacacgagt acagtggcag   2100

atgcctaccg ctggcgcaac cacaccgtgg gcaacaggac cgtggtggag gaaggctact   2160

attatctcaa taattttgac aacatcctca acagctttgt gaccctgttt gagctcacag   2220

ttgtcaacaa ctggtacatc atcatggaag gcgtcacctc tcagacctcc cactggagcc   2280

gcctctactt catgaccttt tacattgtga ccatggtggt gatgacgatc attgtcgcct   2340

ttatcctcga ggccttcgtc ttccgaatga actacagccg caagaaccag gactcggaag   2400

ttgatggtgg catcaccctt gagaaggaaa tctccaaaga agagctggtt gccgtcctgg   2460

agctctaccg ggaggcacgg ggggcctcct cggatgtcac caggctgctg gagaccctct   2520

cccagatgga gagataccag caacattcca tggtgtttct gggacggcga tcaaggacca   2580

agagcgacct gagcctgaag atgtaccagg aggagatcca ggagtggtat gaggagcatg   2640

ccagggagca agagcagcag cgacaactca gcagcagtgc agcccccgcc gcccagcagc   2700

ccccaggcag ccgccagcgc tcccagaccg ttacctagcc cagcgcccga aagccgtctc   2760

ttctatgcaa taacacaata gtattactct aaaaaaaaaa aaaaaaaaaa              2810


<210>  3033
<211>  816
<212>  PRT
<213>  Homosapiens

<400>  3033

Met Ala Val Ser Leu Asp Asp Asp Val Pro Leu Ile Leu Thr Leu Asp 
1               5                   10                  15      


Glu Gly Gly Ser Ala Pro Leu Ala Pro Ser Asn Gly Leu Gly Gln Glu 
            20                  25                  30          


Glu Leu Pro Ser Lys Asn Gly Gly Ser Tyr Ala Ile His Asp Ser Gln 
        35                  40                  45              


Ala Pro Ser Leu Ser Ser Gly Gly Glu Ser Ser Pro Ser Ser Pro Ala 
    50                  55                  60                  


His Asn Trp Glu Met Asn Tyr Gln Glu Ala Ala Ile Tyr Leu Gln Glu 
65                  70                  75                  80  


Gly Glu Asn Asn Asp Lys Phe Phe Thr His Pro Lys Asp Ala Lys Ala 
                85                  90                  95      


Leu Ala Ala Tyr Leu Phe Ala His Asn His Leu Phe Tyr Leu Met Glu 
            100                 105                 110         


Leu Ala Thr Ala Leu Leu Leu Leu Leu Leu Ser Leu Cys Glu Ala Pro 
        115                 120                 125             


Ala Val Pro Ala Leu Arg Leu Gly Ile Tyr Val His Ala Thr Leu Glu 
    130                 135                 140                 


Leu Phe Ala Leu Met Val Val Val Phe Glu Leu Cys Met Lys Leu Arg 
145                 150                 155                 160 


Trp Leu Gly Leu His Thr Phe Ile Arg His Lys Arg Thr Met Val Lys 
                165                 170                 175     


Thr Ser Val Leu Val Val Gln Phe Val Glu Ala Ile Val Val Leu Val 
            180                 185                 190         


Arg Gln Met Ser His Val Arg Val Thr Arg Ala Leu Arg Cys Ile Phe 
        195                 200                 205             


Leu Val Asp Cys Arg Tyr Cys Gly Gly Val Arg Arg Asn Leu Arg Gln 
    210                 215                 220                 


Ile Phe Gln Ser Leu Pro Pro Phe Met Asp Ile Leu Leu Leu Leu Leu 
225                 230                 235                 240 


Phe Phe Met Ile Ile Phe Ala Ile Leu Gly Phe Tyr Leu Phe Ser Pro 
                245                 250                 255     


Asn Pro Ser Asp Pro Tyr Phe Ser Thr Leu Glu Asn Ser Ile Val Ser 
            260                 265                 270         


Leu Phe Val Leu Leu Thr Thr Ala Asn Phe Pro Asp Val Met Met Pro 
        275                 280                 285             


Ser Tyr Ser Arg Asn Pro Trp Ser Cys Val Phe Phe Ile Val Tyr Leu 
    290                 295                 300                 


Ser Ile Glu Leu Tyr Phe Ile Met Asn Leu Leu Leu Ala Val Val Phe 
305                 310                 315                 320 


Asp Thr Phe Asn Asp Ile Glu Lys Arg Lys Phe Lys Ser Leu Leu Leu 
                325                 330                 335     


His Lys Arg Thr Ala Ile Gln His Ala Tyr Arg Leu Leu Ile Ser Gln 
            340                 345                 350         


Arg Arg Pro Ala Gly Ile Ser Tyr Arg Gln Phe Glu Gly Leu Met Arg 
        355                 360                 365             


Phe Tyr Lys Pro Arg Met Ser Ala Arg Glu Arg Tyr Leu Thr Phe Lys 
    370                 375                 380                 


Ala Leu Asn Gln Asn Asn Thr Pro Leu Leu Ser Leu Lys Asp Phe Tyr 
385                 390                 395                 400 


Asp Ile Tyr Glu Val Ala Ala Leu Lys Trp Lys Ala Lys Lys Asn Arg 
                405                 410                 415     


Glu His Trp Phe Asp Glu Leu Pro Arg Thr Ala Leu Leu Ile Phe Lys 
            420                 425                 430         


Gly Ile Asn Ile Leu Val Lys Ser Lys Ala Phe Gln Tyr Phe Met Tyr 
        435                 440                 445             


Leu Val Val Ala Val Asn Gly Val Trp Ile Leu Val Glu Thr Phe Met 
    450                 455                 460                 


Leu Lys Gly Gly Asn Phe Phe Ser Lys His Val Pro Trp Ser Tyr Leu 
465                 470                 475                 480 


Val Phe Leu Thr Ile Tyr Gly Val Glu Leu Phe Leu Lys Val Ala Gly 
                485                 490                 495     


Leu Gly Pro Val Glu Tyr Leu Ser Ser Gly Trp Asn Leu Phe Asp Phe 
            500                 505                 510         


Ser Val Thr Val Phe Ala Phe Leu Gly Leu Leu Ala Leu Ala Leu Asn 
        515                 520                 525             


Met Glu Pro Phe Tyr Phe Ile Val Val Leu Arg Pro Leu Gln Leu Leu 
    530                 535                 540                 


Arg Leu Phe Lys Leu Lys Glu Arg Tyr Arg Asn Val Leu Asp Thr Met 
545                 550                 555                 560 


Phe Glu Leu Leu Pro Arg Met Ala Ser Leu Gly Leu Thr Leu Leu Ile 
                565                 570                 575     


Phe Tyr Tyr Ser Phe Ala Ile Val Gly Met Glu Phe Phe Cys Gly Ile 
            580                 585                 590         


Val Phe Pro Asn Cys Cys Asn Thr Ser Thr Val Ala Asp Ala Tyr Arg 
        595                 600                 605             


Trp Arg Asn His Thr Val Gly Asn Arg Thr Val Val Glu Glu Gly Tyr 
    610                 615                 620                 


Tyr Tyr Leu Asn Asn Phe Asp Asn Ile Leu Asn Ser Phe Val Thr Leu 
625                 630                 635                 640 


Phe Glu Leu Thr Val Val Asn Asn Trp Tyr Ile Ile Met Glu Gly Val 
                645                 650                 655     


Thr Ser Gln Thr Ser His Trp Ser Arg Leu Tyr Phe Met Thr Phe Tyr 
            660                 665                 670         


Ile Val Thr Met Val Val Met Thr Ile Ile Val Ala Phe Ile Leu Glu 
        675                 680                 685             


Ala Phe Val Phe Arg Met Asn Tyr Ser Arg Lys Asn Gln Asp Ser Glu 
    690                 695                 700                 


Val Asp Gly Gly Ile Thr Leu Glu Lys Glu Ile Ser Lys Glu Glu Leu 
705                 710                 715                 720 


Val Ala Val Leu Glu Leu Tyr Arg Glu Ala Arg Gly Ala Ser Ser Asp 
                725                 730                 735     


Val Thr Arg Leu Leu Glu Thr Leu Ser Gln Met Glu Arg Tyr Gln Gln 
            740                 745                 750         


His Ser Met Val Phe Leu Gly Arg Arg Ser Arg Thr Lys Ser Asp Leu 
        755                 760                 765             


Ser Leu Lys Met Tyr Gln Glu Glu Ile Gln Glu Trp Tyr Glu Glu His 
    770                 775                 780                 


Ala Arg Glu Gln Glu Gln Gln Arg Gln Leu Ser Ser Ser Ala Ala Pro 
785                 790                 795                 800 


Ala Ala Gln Gln Pro Pro Gly Ser Arg Gln Arg Ser Gln Thr Val Thr 
                805                 810                 815     


<210>  3034
<211>  1597
<212>  DNA
<213>  Homosapiens

<400>  3034
agccttctgg gtccgaggct cccacctgct ctaagcgctt gacacccttt aaaaaaatgt     60

atttaaagag gctggttcct atccatccga ctggaggcat ctcagtgcaa gagcaaagct    120

aagtcctgca cacgctcctc ccctcctcct cctccttctc cccccaggtt ttcccgaatg    180

tatctactcc ggttacaact agacgcggcc cctcccccac ctgcctcccc ccttccttcc    240

ctcgatcgtg gagggagcgt tctctgtgcc ttcccaagtc cccgtggggg accttctatg    300

ttggagtggg gggagggggg gagggtcata taacgaaggc cagaaagaac aaattagata    360

atcaaaagaa ttatagtaat tgctttcact ttcccccgcc cgctcagcgg attccctccc    420

ccgcccctcc cctggttttt ctgtctgtcg ggaatactcg gtctttccga ccccctcccc    480

tcccccaggt tcctcctctc ctctcccctt gctcgcgcgt tccctctctt cctccgtttt    540

ctggtgtgct ggaacgttca gcggaatatg atgaatgatc acctgtcaca gcttgtttat    600

tataatgcag gcaatcaatt acacatcccc aatgctggcc ggcccgcagg aaatttatat    660

gctcagcaca aaccaatgtg aaaatggaat ctcatttgcc aaatgtcttt ctccccgtac    720

agcacgatga ttacagtctg tgtttgtttc aacagtcgtg tacaactgac agtgccatca    780

tttactgcct ggctcaggtc acgttactct aaggctttat ttatggtgtt acgaagggca    840

gcacaggaaa aggacaaggg tgtctgtcag ggatggcact gtgttaaaaa gtgggcgtgc    900

aagggccgca ttcccgggca gccgctgcaa cctcagcccc tgggccctta cctccgcagc    960

ctctcccagc atccagctac ccagactcca aggccccagg cgagagccag ctctcggtac   1020

ctggagctcc acaggtccca gaatcggggt gggtcagagt tcaaattctg gttctgctac   1080

tgtctaattg cgtgctgcag ggactcaatc tcttcatctg ggaaatggga gtaataaccc   1140

ttggcaggaa tgttgcgatc ctctgggatg tcagaggtgt tgatgaatgt tagttcccgg   1200

gacttcggaa agaggtcccg ttggaagaga tgtgaattgg aattcacacc ctatattaaa   1260

atctcctcca atcttcacct ctgagacatg gctgtctcaa gactgttttg tttcccttcc   1320

tggtggaatt ttgcactttt atgtcctgtg tagcagcagg tagtgtggct ttgagaaaat   1380

aaaatggcca ccttgctccg ctgttctttc tttgtaaaaa aaaaaaaaaa aaaaaaaaaa   1440

cggcatagca atcttggcct ttctagctgt gtgaccccag gccggtcaat ccctcctcct   1500

ctccaagcct cggattcctc ccctgagaag taaagaaaat aactcctaaa ctgcctcccg   1560

aggcttgctg gcaggatcca aggtgtccag agatgtt                            1597


<210>  3035
<211>  143
<212>  PRT
<213>  Homosapiens

<400>  3035

Met Ser Phe Ser Pro Tyr Ser Thr Met Ile Thr Val Cys Val Cys Phe 
1               5                   10                  15      


Asn Ser Arg Val Gln Leu Thr Val Pro Ser Phe Thr Ala Trp Leu Arg 
            20                  25                  30          


Ser Arg Tyr Ser Lys Ala Leu Phe Met Val Leu Arg Arg Ala Ala Gln 
        35                  40                  45              


Glu Lys Asp Lys Gly Val Cys Gln Gly Trp His Cys Val Lys Lys Trp 
    50                  55                  60                  


Ala Cys Lys Gly Arg Ile Pro Gly Gln Pro Leu Gln Pro Gln Pro Leu 
65                  70                  75                  80  


Gly Pro Tyr Leu Arg Ser Leu Ser Gln His Pro Ala Thr Gln Thr Pro 
                85                  90                  95      


Arg Pro Gln Ala Arg Ala Ser Ser Arg Tyr Leu Glu Leu His Arg Ser 
            100                 105                 110         


Gln Asn Arg Gly Gly Ser Glu Phe Lys Phe Trp Phe Cys Tyr Cys Leu 
        115                 120                 125             


Ile Ala Cys Cys Arg Asp Ser Ile Ser Ser Ser Gly Lys Trp Glu 
    130                 135                 140             


<210>  3036
<211>  2490
<212>  DNA
<213>  Homosapiens

<400>  3036
atgacggatg aacaggtgtg cgagactgtg gagaaatacg gagccaaccg ggaggagtgt     60

gcccgcctca acgcctccct ctcctgcctc aggaatgtcc acatgtcagg aggcaacctt    120

tccaaacaag actggaccat ccagtggccc accacagaga cggggaagga gaacaatccc    180

gtgtgccccc cggagcccac cccgtggatc cgcacccatc tctcccagag ccccagggtc    240

ccgtccaagt gcgtccagca ctattgtcac accagcccca ctcccggggc ccctgtgtac    300

acccacgtgg acaggcttac cgtggacgcc tacccgggct tgtgcccgcc cccgccactg    360

gagtcgggcc accgttccct gcccccatcg ccccggcagc ggcacgcggt ccgcaccccg    420

ccgcgcaccc ccaacatcgt caccaccgtg accccgccgg gcacgccgcc catgaggaag    480

aagaacaagc tgaagccccc ggggacccca ccgccctcct cccgaaaact gatacacttg    540

atcccgggat tcaccgcgct gcatcggagc aaatcccacg agttccagct ggggcaccgc    600

gtggacgagg cccacacgcc caaagccaag aagaagagca aacccttgaa cctcaagatc    660

cacagcagcg taggcagctg cgagaacatc ccctctcagc agcgctcccc gctgctgtcc    720

gagcgctccc tccgctcctt ctttgtggga cacgcacctt tcctgccttc cacccctcct    780

gttcacactg aggccaactt ctctgcaaac acactgtcag tgccacgctg gtccccgcag    840

atccctcgca gagatctcgg caactccatc aagcacaggt tttccaccaa gtactggatg    900

tctcagacgt gcacagtctg tgggaaaggg atgctttttg gcctcaagtg taaaaactgc    960

aagttaaagt gccacaacaa atgcaccaaa gaagccccac cctgtcatct tctgatcatc   1020

caccgaggag atccagcaag gttagtccgg acagagtccg ttccgtgtga catcaacaac   1080

cctctacgga agccacctcg ctattcagac ctgcacatca gtcagacgct ccccaaaacc   1140

aacaaaatca acaaggacca catccctgtc ccttaccagc cagactccag cagcaacccc   1200

tcctccacga cgtcctccac gccctcctcg ccagcacccc ccctccctcc tagtgccacg   1260

ccgccttctc ccctacaccc ttccccacag tgcacacggc agcagaagaa cttcaacctg   1320

ccagcatccc actactacaa atacaagcag cagttcatct tcccagatgt ggtgccggtg   1380

ccggagacgc cgacccgggc gccccaggtc atcctgcatc cggtgacctc gaatccaatc   1440

ttggaaggaa atccattact tcaaattgaa gtggagccaa cgtcggagaa tgaagaggtc   1500

catgatgagg ccgaagagtc agaggatgac ttcgaggaga tgaacctgtc cctcctctcg   1560

gcccggagct tcccacgcaa ggccagccag accagcatct tccttcagga gtgggacatc   1620

ccctttgagc agctggagat cggcgagctc attggaaagg gccgctttgg gcaagtgtac   1680

cacggccgct ggcatggcga ggtggccatc cggctgattg acattgagag ggacaacgag   1740

gaccagctca aggccttcaa gcgggaggtg atggcctaca ggcagacacg gcatgagaac   1800

gtggtgcttt tcatgggtgc ctgcatgagc ccgcctcacc tggccatcat caccagcctc   1860

tgtaagggac ggacgctcta ttccgttgtg agggatgcca aaatcgtttt ggatgtcaac   1920

aaaaccaggc agattgctca agaaattgtg aagggcatgg gctacctcca cgccaaggga   1980

atcctacaca aggacctcaa gtcaaagaac gtcttctatg acaacggcaa agtggtcatc   2040

acggactttg gactcttcag catttctggg gtgctgcagg ctggcaggcg ggaggacaaa   2100

ctgcgcatcc agaatggctg gctatgccac ctggcaccag agatcatccg ccagctgtcc   2160

cccgacacag aggaggataa gctccccttc tccaagcact ctgacgtctt tgcccttggc   2220

acaatctggt atgaactcca cgccagggaa tggcctttca agacccaacc agcagaggca   2280

ataatctggc aaatgggcac aggcatgaaa cccaacctca gccagattgg catgggaaaa   2340

gaaatctcgg acattcttct cttctgctgg gcctttgaac aagaagagag acctaccttc   2400

accaagctca tggacatgct ggagaaactg ccaaagcgaa accgtcgcct gtctcaccct   2460

ggacatttct ggaagtctgc agagctgtga                                    2490


<210>  3037
<211>  829
<212>  PRT
<213>  Homosapiens

<400>  3037

Met Thr Asp Glu Gln Val Cys Glu Thr Val Glu Lys Tyr Gly Ala Asn 
1               5                   10                  15      


Arg Glu Glu Cys Ala Arg Leu Asn Ala Ser Leu Ser Cys Leu Arg Asn 
            20                  25                  30          


Val His Met Ser Gly Gly Asn Leu Ser Lys Gln Asp Trp Thr Ile Gln 
        35                  40                  45              


Trp Pro Thr Thr Glu Thr Gly Lys Glu Asn Asn Pro Val Cys Pro Pro 
    50                  55                  60                  


Glu Pro Thr Pro Trp Ile Arg Thr His Leu Ser Gln Ser Pro Arg Val 
65                  70                  75                  80  


Pro Ser Lys Cys Val Gln His Tyr Cys His Thr Ser Pro Thr Pro Gly 
                85                  90                  95      


Ala Pro Val Tyr Thr His Val Asp Arg Leu Thr Val Asp Ala Tyr Pro 
            100                 105                 110         


Gly Leu Cys Pro Pro Pro Pro Leu Glu Ser Gly His Arg Ser Leu Pro 
        115                 120                 125             


Pro Ser Pro Arg Gln Arg His Ala Val Arg Thr Pro Pro Arg Thr Pro 
    130                 135                 140                 


Asn Ile Val Thr Thr Val Thr Pro Pro Gly Thr Pro Pro Met Arg Lys 
145                 150                 155                 160 


Lys Asn Lys Leu Lys Pro Pro Gly Thr Pro Pro Pro Ser Ser Arg Lys 
                165                 170                 175     


Leu Ile His Leu Ile Pro Gly Phe Thr Ala Leu His Arg Ser Lys Ser 
            180                 185                 190         


His Glu Phe Gln Leu Gly His Arg Val Asp Glu Ala His Thr Pro Lys 
        195                 200                 205             


Ala Lys Lys Lys Ser Lys Pro Leu Asn Leu Lys Ile His Ser Ser Val 
    210                 215                 220                 


Gly Ser Cys Glu Asn Ile Pro Ser Gln Gln Arg Ser Pro Leu Leu Ser 
225                 230                 235                 240 


Glu Arg Ser Leu Arg Ser Phe Phe Val Gly His Ala Pro Phe Leu Pro 
                245                 250                 255     


Ser Thr Pro Pro Val His Thr Glu Ala Asn Phe Ser Ala Asn Thr Leu 
            260                 265                 270         


Ser Val Pro Arg Trp Ser Pro Gln Ile Pro Arg Arg Asp Leu Gly Asn 
        275                 280                 285             


Ser Ile Lys His Arg Phe Ser Thr Lys Tyr Trp Met Ser Gln Thr Cys 
    290                 295                 300                 


Thr Val Cys Gly Lys Gly Met Leu Phe Gly Leu Lys Cys Lys Asn Cys 
305                 310                 315                 320 


Lys Leu Lys Cys His Asn Lys Cys Thr Lys Glu Ala Pro Pro Cys His 
                325                 330                 335     


Leu Leu Ile Ile His Arg Gly Asp Pro Ala Arg Leu Val Arg Thr Glu 
            340                 345                 350         


Ser Val Pro Cys Asp Ile Asn Asn Pro Leu Arg Lys Pro Pro Arg Tyr 
        355                 360                 365             


Ser Asp Leu His Ile Ser Gln Thr Leu Pro Lys Thr Asn Lys Ile Asn 
    370                 375                 380                 


Lys Asp His Ile Pro Val Pro Tyr Gln Pro Asp Ser Ser Ser Asn Pro 
385                 390                 395                 400 


Ser Ser Thr Thr Ser Ser Thr Pro Ser Ser Pro Ala Pro Pro Leu Pro 
                405                 410                 415     


Pro Ser Ala Thr Pro Pro Ser Pro Leu His Pro Ser Pro Gln Cys Thr 
            420                 425                 430         


Arg Gln Gln Lys Asn Phe Asn Leu Pro Ala Ser His Tyr Tyr Lys Tyr 
        435                 440                 445             


Lys Gln Gln Phe Ile Phe Pro Asp Val Val Pro Val Pro Glu Thr Pro 
    450                 455                 460                 


Thr Arg Ala Pro Gln Val Ile Leu His Pro Val Thr Ser Asn Pro Ile 
465                 470                 475                 480 


Leu Glu Gly Asn Pro Leu Leu Gln Ile Glu Val Glu Pro Thr Ser Glu 
                485                 490                 495     


Asn Glu Glu Val His Asp Glu Ala Glu Glu Ser Glu Asp Asp Phe Glu 
            500                 505                 510         


Glu Met Asn Leu Ser Leu Leu Ser Ala Arg Ser Phe Pro Arg Lys Ala 
        515                 520                 525             


Ser Gln Thr Ser Ile Phe Leu Gln Glu Trp Asp Ile Pro Phe Glu Gln 
    530                 535                 540                 


Leu Glu Ile Gly Glu Leu Ile Gly Lys Gly Arg Phe Gly Gln Val Tyr 
545                 550                 555                 560 


His Gly Arg Trp His Gly Glu Val Ala Ile Arg Leu Ile Asp Ile Glu 
                565                 570                 575     


Arg Asp Asn Glu Asp Gln Leu Lys Ala Phe Lys Arg Glu Val Met Ala 
            580                 585                 590         


Tyr Arg Gln Thr Arg His Glu Asn Val Val Leu Phe Met Gly Ala Cys 
        595                 600                 605             


Met Ser Pro Pro His Leu Ala Ile Ile Thr Ser Leu Cys Lys Gly Arg 
    610                 615                 620                 


Thr Leu Tyr Ser Val Val Arg Asp Ala Lys Ile Val Leu Asp Val Asn 
625                 630                 635                 640 


Lys Thr Arg Gln Ile Ala Gln Glu Ile Val Lys Gly Met Gly Tyr Leu 
                645                 650                 655     


His Ala Lys Gly Ile Leu His Lys Asp Leu Lys Ser Lys Asn Val Phe 
            660                 665                 670         


Tyr Asp Asn Gly Lys Val Val Ile Thr Asp Phe Gly Leu Phe Ser Ile 
        675                 680                 685             


Ser Gly Val Leu Gln Ala Gly Arg Arg Glu Asp Lys Leu Arg Ile Gln 
    690                 695                 700                 


Asn Gly Trp Leu Cys His Leu Ala Pro Glu Ile Ile Arg Gln Leu Ser 
705                 710                 715                 720 


Pro Asp Thr Glu Glu Asp Lys Leu Pro Phe Ser Lys His Ser Asp Val 
                725                 730                 735     


Phe Ala Leu Gly Thr Ile Trp Tyr Glu Leu His Ala Arg Glu Trp Pro 
            740                 745                 750         


Phe Lys Thr Gln Pro Ala Glu Ala Ile Ile Trp Gln Met Gly Thr Gly 
        755                 760                 765             


Met Lys Pro Asn Leu Ser Gln Ile Gly Met Gly Lys Glu Ile Ser Asp 
    770                 775                 780                 


Ile Leu Leu Phe Cys Trp Ala Phe Glu Gln Glu Glu Arg Pro Thr Phe 
785                 790                 795                 800 


Thr Lys Leu Met Asp Met Leu Glu Lys Leu Pro Lys Arg Asn Arg Arg 
                805                 810                 815     


Leu Ser His Pro Gly His Phe Trp Lys Ser Ala Glu Leu 
            820                 825                 


<210>  3038
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3038
cagaaagcca gccctccctt cccttcttgg ggcgcagagg ctcagccagc tcagagcgca     60

gcctggagcc gacccagaag ggcgaagaaa gcccagcgga cgagcctcct ttctctgctg    120

cctgcccggg ctggggcgtc ccatcccccg ccctgaactc cgatctctcc caccccaccc    180

ctctctgggt ttcacccgga cagagccggg agctgggtgt cgcccccgtt tggaatccac    240

gtttcagcac tttggacagc gccccggacg ccccggcccc tttgggttgg cgatggcgag    300

cgttcagcaa ggcgagaagc agctttttga gaagttctgg cgaggaacct tcaaagcggt    360

ggccaccccc cgtcccgaga gcatcattgt cgccagtatc acggcccgca agccgctgcc    420

aaggacagag ccccagaata accccgttgt cccagctcag gatggaccct cagaaaagct    480

gggtcagcat ctggccaccg agcccttggg caccaacagt tgggagagag acaagacctg    540

tcgggaactg ggtgccacca gaggacacag tgcctctcat gacaaagact tgacaccacc    600

accttcctcc aggggaaaga agaaaaagaa gaaatccact cggaagaaga gaaggaggtc    660

ctcatcctat agcccatcgc ctgtcaagaa aaagaagaag aaaagttcca agaaacacaa    720

gcgacgcagg tcattctcca agaagagaag gcacagctcc tctagcccaa aaagcaaaag    780

aagagatgag aagaggcaca agaaacaatc tcgaagccgg ccccgaaagt ctcaccgcca    840

ccgccatcac cgctgcccct cgcggtccca gagctcggag tcccgcccct caagctgtga    900

gagcaggcac cgcggccggt cccctgagga agggcagaag tcccgccgaa ggcactcccg    960

ccgctgctcc aagaccctct gcaaggacag ccctgaggcc cagtccagtc gcccgcccag   1020

tcaacccctc cagatgcttg gctacctgtc agccaggggt gtaatcactg ggtcggggtc   1080

tgctgctgac ctctttacca aaacagccag cccgctcacc acctcgcgag gacgttccca   1140

ggagtacgac tcaggaaatg acacgtcctc gccaccctcc acgcaaacca gctcagccag   1200

gtctcggggc caggagaagg ggagccccag tgggggcttg agcaagagcc gggagctcaa   1260

cagtggcaac acctctgatt cagggaactc cttcaccacc tcctcacccc agaacaaggg   1320

ggccatgttg gagaatctct cccccaccag caggggcaga gagtcaaggg gatttcagtc   1380

accgtgtctg gaatgtgccg aagtgaagaa gtccagtttg gtcccatcca cagcccggag   1440

ctcacccatg aaagggtgtt cccgcagctc ctcctatgcc agcacccgat cctccagtca   1500

ctcgtcccga tccccaaatc ccagggcttc ccccaggtac acccaaagcc gatccacctc   1560

ttctgaaaaa aggtcctact cccgctctcc cagctattcc tccaagtctg gcaagaggag   1620

cccgcccagc agaagctcta ggtcccgccg cagccctagc tactcccgct acagccccag   1680

cagggagcgg gatcccaaat acagtgagaa ggactcgcag cagcgggagc gcgagcgagc   1740

gcgtcggaga cgtcggtcct actcgcctat gagaaagcgc cggagagact ccccgagcca   1800

cctggaggcc cggaggataa ccagtgcccg gaaacgcccc atcccctact atcggcccag   1860

cccctcctca tccggcagcc tcagcagcac ctcctcctgg tacagcagca gcagtagccg   1920

ctcggccagc cgcagctact cccggagccg gagtcggagc cggagccgga gacggagccg   1980

gacccgcacg agcagcagct ctagctcccg cagccctagt ccgggctccc gcagccggag   2040

ccggagcagg agccggagcc ggagccggag caggagccag agccggagct acagctcagc   2100

agacagctac tccagcacga ggcgctaagt gcccctgagc cagctgcccg tgggggcccc   2160

ttcgcgctgc cagcctcccc caaccacctg ccctccccgc cttcttggtg acaaatagtg   2220

agggctccta taccttgtcc ttcctgcttg cctaggggaa gaggagaaga gggtaagggg   2280

gcttcactct ctagatcagc ctgctaggag cctctaccag catcatcctg gggcccagct   2340

caggcctggg catatggaaa gaaccatcat cttgtggcac aaaaaaagaa gaaagaaaag   2400

aaaacttcaa ggttttgtga gaagcaatgg gtctgtgact caaaaattga gccctggcca   2460

ggaaaatgtg gagacagttc ttctcctcca ctgctcacag gaggcccgtg gtaattctcc   2520

ccacctcccc ggatgcccca ctagtccaac ttcatggctg cacgtggatg gacccccatg   2580

tctgagaggg gtgaaagagg agaccaatgg cagttcaggt tcaagataac ggggtcaggc   2640

ctttaacttc ctcaaacagg cccaagcaaa ggctggaaga catttgggtc ctagaagaag   2700

ggatatcctt gaataccaga tggggacgtt tgacttggtg ggaggtgtca ggagatagga   2760

gttggttaag atgatagata gaaaaacgga agggttcagc tgctgctccc aatacctcag   2820

catggtaagg ggacagagcc cagcagatcc cagctgtgaa gaggccactg catggctgac   2880

acaaaacacc tcttggccat tcacaggggc cctgcaacct cacgagaaag gagatagtgg   2940

aagagtcagg acaggttggt ctccagcccc acttcccaaa tatgcctcag ccccactagc   3000

tggcaccaac ttaattccac gggaccatct gctgaacatt ccccagtgcc atggccagtt   3060

gccaggcccc agcgccagcc agtctggcct taccctccgg ttggcgcctg ccagccccct   3120

cccctctgcc caggctgcca cgccctggat gccacccagt gcagcctggc acctacccac   3180

ccacccttca gcttaagcca ctccccttgc ctctcaggaa ttttgccagg atggggcaca   3240

gcagctcagg tttgggggaa aagacccgaa tccagagtgc aggggagagg ggcttggata   3300

tgccatgtct tgggctcctg ctggcttctg aggtttcttg tcagcttggg aaagacccac   3360

ctttattttt gccctcaccc caagtccccc ctggctgggg ctgggcagag agggtaagct   3420

gatctccgat ccacaaatac caccagctgc ttcatccaca gaaggcgcta agaacgggga   3480

ggtgaggaat aagatcctta aaataaactc ttgggcatcc ccctcaccag ctgactggct   3540

ttccggaggc ttgtgggtga gtttcaagtt tgtggtggca acagcagcag gacagggcac   3600

ggagggagcg agggagagag gaccggtccc agcttttgga tattttgggt tatggggaag   3660

caagggccaa acattcttta tccctcccac cccagggaaa acatttggaa aatagtcctt   3720

tttcttggaa gcagtgacgt ctccctaccc aatctttccc atcctatcaa cccatggggc   3780

tagagactgc catgcaacca ccaccacgac agcccttcct ccatcagaag acaggagtga   3840

gggccccggg cagcagtgga cgacccagcc tccccatacc gggcctctgg cccagaccta   3900

agccctgccc acaaagacta atggatgcca gtgctgtcac tgcagaaggc cagatggcag   3960

gtgcctggga caggggcagg tgccccgggg agggcaagta cagccactgt aaataaccct   4020

cgtccctgcc caggaaccca gactggactt cagtctccct ccatggagac aaaggcttcc   4080

cagagccacc aaaaaccttc ttagcaggac agctgtgaga ggcatcagaa cctcacgttc   4140

ggactgcctt catcaagaca actctagggg accattttgc ctggggctcc tagcaaacct   4200

ttttatttat tttatttatt tatctattta tttatttgat gactgtctct ctttctcgcc   4260

attagcagta ttgaattatt tatttataca gaggttttgt gtgtgtgtgt gtgtgtgtgt   4320

gtgtgtgtgt gtgtgtgtgt gtgtgtgttg gggggatctc ctaaattatt tctgtgcatc   4380

tccttttttt ttctgctgtt ttttatggat gggatttgag aggccaaagg tgagtgggct   4440

attggccttc tccctgaagg ctctaagcct ggaacaccct ggggttggcc cagaaggagg   4500

cacatcagtc ccaaaattca tcacttaacc cagcgtccag gagggtcagg cctgtacccc   4560

agcctcctgt cccccaggaa cctcacaggg gtatcaaaaa gatgtaaaca gcccagaggc   4620

ttatgagcta cagtgatgaa ttgacacagt ggagttgcaa cttaggtggg ggttggagtc   4680

gaaagttggc aaatggggcc aaggctgcac aaagtcgaaa tcccttgtga atgtccctta   4740

gggaggcacc agattggaga cagatgtgct atctcctaac agagtgatga ggcttcagtt   4800

gagtacttgc tgaagtagtt gccttgtatt ttgagggcca tggtggatga aaatgatgtc   4860

tggtttagta ctggaattgc acttggggtt gacaaggtgc tcacaccatg agaatggagg   4920

caggaattga gctgactgag ggaagatgca ccttgatctc accctcactc caaggcacat   4980

agcaggatca ctccctagct tctctgagca cacctagttg gtttcatgta tgttacacat   5040

gcttccactc cacagtacct aatttctctc tgtcccctga gatctgaagg ctaccttggg   5100

aagaggcatc agccatcttg cttgagaacc accaagccaa aagcaaaagc ttttatctat   5160

gatctcttgc tgtttcatca ggggaaagca caaagctatt tctgaaatta ggaaaaaaaa   5220

aaaaaaggtg gaaggagcag ccagatgttc cacaggaccc caccaagaag gtcatttcca   5280

aacccatcct ggaagggccc aggatccaaa ggtcatcagt cctgcttatc tgaccaactg   5340

gcagtgtctt ctggctgctg gccggagaca gctcttgccc tttccaaagt cactgtccac   5400

tgccttgcaa ttgccagctt gtctggtcca gctttgggtt tggtgagact tttgcaacat   5460

ccctggttgt ttccctggca atgtgactat ccagccctaa cccaaagcaa gggagtgccc   5520

ctttcctggg tgaagtttac aagaaggctg cttaaatgcc tgcttcgggg aaatctctgc   5580

ctctctctct ctctgtctct ctctctgtct ctctctctgt ctctctctct ctctctctct   5640

ctctctctct ctcagtgtat ttctctactt tcttttacat ttcctttttt tctatccaaa   5700

aacaatgtgc ttgttgaggc actggtaacc ctgattaacc agaacctccc attcccagta   5760

tcgctgttcc tacgcccatt tcaccctcat taccttctgc ttccaaggaa tatgacagat   5820

caccaggatg ctgctcgtcg tgaggattta tctcaaaaac caacatccaa aatgggaggg   5880

agatgtggct tgaggtcaag cgccatgcat cccaagcctt tgaccttccc gctatggaag   5940

tgcactggat gacagaaact gaatacattg ctccctttcc ctagggcaaa gttcgacctc   6000

tgttaagtgg agggatttgt gagataaaaa ttcaaaatgt tggcctgagg cctgagagtg   6060

tcaccaaaga cagagggagc ttcactgaga ctcagaggga aaaggaaaag agcctcaaac   6120

atttttagga ggttgtccat catgaaagta aaaacgaaaa gcaagatttg atctcccttc   6180

agttaattag gcaaggctaa gtaactcaaa gccccctatt agtaacattc tggttcactg   6240

aggtttgatc atattcctat ctgcattcct tcccttcttt gaaggacagc tgatctttca   6300

gaagcagaat aaaattaaga tgttagaaca aaggtctcag tctcagagaa ccgcatcact   6360

tcatttgctc agacccatcc tcttttgcaa aagggtctgc ttggagaggc caaaattcag   6420

ggtgctctca aaggcaaaga aagcacattg ttttccttct ccagtccaac tttcatcttt   6480

tcttctgctg ttttcttttc ccctcttctt tttcacaaat gttcaaaatg gtctcatgcg   6540

catgtgtctt gccccacttt cccctttagc tgaacagaaa attttgtctc agtaaaacga   6600

agtcaaaaaa caggattcct ccaaacatgc ctcctcccgc actggccagc cgagtccagc   6660

tgagaaactt atgctagatt caatgtcatt gagcaatgct ttattgaagt ctcgttcttc   6720

tcacttctgc accagtgagc caatgatact gacagaaatg tcatctctct tctatctgtg   6780

gttgctgttt ttggagtaaa agtttctgtg tgtgtttttt tagttctttt gatggctgtt   6840

gttttgcatt gtaaatacca tgatggggga cccccatcag aacatggctt atttaataat   6900

ttatttcgta tttattgagt aatattggga aaagagaagg accacctctt tccctgaatt   6960

gctattgaga attggtccat ctcccagctc caggtgctgc tgtctgcagc aagggcatta   7020

ctgcccaggt aaggagtgct agaatcacca agcaaattga aattggcaga aatggaggct   7080

tcagtcacac aaattagact caaatggaac taaaacactg gttatctcca ggaaaacctc   7140

atttagatgg aaattaatgg aagaataaaa tgcctacaca tgaaccaact tctattaaaa   7200

agtcacaact ccttgaaaaa aaaaataaag aaaaattgta aactcttttt tttttctggc   7260

caaggaaagc tatgcctcat cttctaacga gccaagccaa aaagactgca atggtattcc   7320

tatgtgtttc tttggcctgt gtatcagtct gaatgaaatg gaatgggtct ctagcctcag   7380

tcttgtcatc tgtaaaatgg ggcttgtcct atatattatc tgcaagacgt gggaaatggg   7440

ggctcaagcc ctgatgctat ggactccata ctgttggata tattgtctct tgtgtcttct   7500

gctgactgca gattaaaggg tgtcaaccaa ggaaggaaac aaaaaagtag ggcctggact   7560

tcatttgcag aatgaggtca tagtcgttga gtcccacagt catatatggg agacctcaag   7620

ttgctgtcac cttgataact cttgtatcct gggttaaagc cctctgtatt tagtttgaac   7680

ttctctctaa gccccgtggt ccaaagtcat cacgggagag accaagatgg gcttaccttg   7740

ccctgctctg gatttaacca ttgttcattg tcaggctata tttttgtaca atcattcaaa   7800

taacccagtg acataggtca tattgccact tttcagagga gaaaactgag gctcaggagg   7860

gggagttgac atgcccaagc tcccttgagc tcagatcagc ttgactcaat gtccaacatt   7920

cccttggtag ctttttctcc ggggtcctgt gctataagaa cttctctctg cactgtattt   7980

ttttttctcc caattcttag ctatttcctc aagcaatgat tggccaagga cctagcataa   8040

tccaccacat tggccaaggg gacgtggtgc accccaaggc catttctctg cattggaggc   8100

tgcgaatctc ctctggaaaa ttcccaaccc gaggacccac catgagccca gctcagcctg   8160

accagacagc ctctgcctgg agcattcaca tc                                 8192


<210>  3039
<211>  611
<212>  PRT
<213>  Homosapiens

<400>  3039

Met Ala Ser Val Gln Gln Gly Glu Lys Gln Leu Phe Glu Lys Phe Trp 
1               5                   10                  15      


Arg Gly Thr Phe Lys Ala Val Ala Thr Pro Arg Pro Glu Ser Ile Ile 
            20                  25                  30          


Val Ala Ser Ile Thr Ala Arg Lys Pro Leu Pro Arg Thr Glu Pro Gln 
        35                  40                  45              


Asn Asn Pro Val Val Pro Ala Gln Asp Gly Pro Ser Glu Lys Leu Gly 
    50                  55                  60                  


Gln His Leu Ala Thr Glu Pro Leu Gly Thr Asn Ser Trp Glu Arg Asp 
65                  70                  75                  80  


Lys Thr Cys Arg Glu Leu Gly Ala Thr Arg Gly His Ser Ala Ser His 
                85                  90                  95      


Asp Lys Asp Leu Thr Pro Pro Pro Ser Ser Arg Gly Lys Lys Lys Lys 
            100                 105                 110         


Lys Lys Ser Thr Arg Lys Lys Arg Arg Arg Ser Ser Ser Tyr Ser Pro 
        115                 120                 125             


Ser Pro Val Lys Lys Lys Lys Lys Lys Ser Ser Lys Lys His Lys Arg 
    130                 135                 140                 


Arg Arg Ser Phe Ser Lys Lys Arg Arg His Ser Ser Ser Ser Pro Lys 
145                 150                 155                 160 


Ser Lys Arg Arg Asp Glu Lys Arg His Lys Lys Gln Ser Arg Ser Arg 
                165                 170                 175     


Pro Arg Lys Ser His Arg His Arg His His Arg Cys Pro Ser Arg Ser 
            180                 185                 190         


Gln Ser Ser Glu Ser Arg Pro Ser Ser Cys Glu Ser Arg His Arg Gly 
        195                 200                 205             


Arg Ser Pro Glu Glu Gly Gln Lys Ser Arg Arg Arg His Ser Arg Arg 
    210                 215                 220                 


Cys Ser Lys Thr Leu Cys Lys Asp Ser Pro Glu Ala Gln Ser Ser Arg 
225                 230                 235                 240 


Pro Pro Ser Gln Pro Leu Gln Met Leu Gly Tyr Leu Ser Ala Arg Gly 
                245                 250                 255     


Val Ile Thr Gly Ser Gly Ser Ala Ala Asp Leu Phe Thr Lys Thr Ala 
            260                 265                 270         


Ser Pro Leu Thr Thr Ser Arg Gly Arg Ser Gln Glu Tyr Asp Ser Gly 
        275                 280                 285             


Asn Asp Thr Ser Ser Pro Pro Ser Thr Gln Thr Ser Ser Ala Arg Ser 
    290                 295                 300                 


Arg Gly Gln Glu Lys Gly Ser Pro Ser Gly Gly Leu Ser Lys Ser Arg 
305                 310                 315                 320 


Glu Leu Asn Ser Gly Asn Thr Ser Asp Ser Gly Asn Ser Phe Thr Thr 
                325                 330                 335     


Ser Ser Pro Gln Asn Lys Gly Ala Met Leu Glu Asn Leu Ser Pro Thr 
            340                 345                 350         


Ser Arg Gly Arg Glu Ser Arg Gly Phe Gln Ser Pro Cys Leu Glu Cys 
        355                 360                 365             


Ala Glu Val Lys Lys Ser Ser Leu Val Pro Ser Thr Ala Arg Ser Ser 
    370                 375                 380                 


Pro Met Lys Gly Cys Ser Arg Ser Ser Ser Tyr Ala Ser Thr Arg Ser 
385                 390                 395                 400 


Ser Ser His Ser Ser Arg Ser Pro Asn Pro Arg Ala Ser Pro Arg Tyr 
                405                 410                 415     


Thr Gln Ser Arg Ser Thr Ser Ser Glu Lys Arg Ser Tyr Ser Arg Ser 
            420                 425                 430         


Pro Ser Tyr Ser Ser Lys Ser Gly Lys Arg Ser Pro Pro Ser Arg Ser 
        435                 440                 445             


Ser Arg Ser Arg Arg Ser Pro Ser Tyr Ser Arg Tyr Ser Pro Ser Arg 
    450                 455                 460                 


Glu Arg Asp Pro Lys Tyr Ser Glu Lys Asp Ser Gln Gln Arg Glu Arg 
465                 470                 475                 480 


Glu Arg Ala Arg Arg Arg Arg Arg Ser Tyr Ser Pro Met Arg Lys Arg 
                485                 490                 495     


Arg Arg Asp Ser Pro Ser His Leu Glu Ala Arg Arg Ile Thr Ser Ala 
            500                 505                 510         


Arg Lys Arg Pro Ile Pro Tyr Tyr Arg Pro Ser Pro Ser Ser Ser Gly 
        515                 520                 525             


Ser Leu Ser Ser Thr Ser Ser Trp Tyr Ser Ser Ser Ser Ser Arg Ser 
    530                 535                 540                 


Ala Ser Arg Ser Tyr Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Arg 
545                 550                 555                 560 


Arg Ser Arg Thr Arg Thr Ser Ser Ser Ser Ser Ser Arg Ser Pro Ser 
                565                 570                 575     


Pro Gly Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg 
            580                 585                 590         


Ser Arg Ser Gln Ser Arg Ser Tyr Ser Ser Ala Asp Ser Tyr Ser Ser 
        595                 600                 605             


Thr Arg Arg 
    610     


<210>  3040
<211>  2056
<212>  DNA
<213>  Homosapiens

<400>  3040
ccacagccca gctgttccct ccgcggattc tccggggctg gttcatcacc tccgaatatt     60

cctgtgacag gagacgcttg caaaacccgc ctccagcctc cagcagcaaa taaatagaag    120

gcttgcagcc cagaaggagc cagaagaagt ttctaggcgc gcgtgccctg ggtttattaa    180

gctcctggct ccgctctaga cctcagcggt tctggctgcc agcctgggca gcctgggaag    240

cctgggagga cggtggcttg ccggtctgtc gtgaggcagt gcggacgggg accctctggg    300

attctgctgg atctgccccg ggggttacct ttgggggctg ggaccccagt cgaggggaca    360

caaccgtccc tggcagtggt tggttctgct tctccctgca gaaaagcagc attttcggaa    420

gctgaagaat aagctagccc agccacacca ccttgttgtg tgaccttggg caggtggttc    480

tgtctctctg agcctctgtt tctctctgag ctgagcagcc accatggctg acggtcagat    540

gcccttctcc tgccactacc caagccgcct gcgccgagac cccttccggg actctcccct    600

ctcctctcgc ctgctggatg atggctttgg catggacccc ttcccagacg acttgacagc    660

ctcttggccc gactgggctc tgcctcgtct ctcctccgcc tggccaggca ccctaaggtc    720

gggcatggtg ccccggggcc ccactgccac cgccaggttt ggggtgcctg ccgagggcag    780

gaccccccca cccttccctg gggagccctg gaaagtgtgt gtgaatgtgc acagcttcaa    840

gccagaggag ttgatggtga agaccaaaga tggatacgtg gaggtgtctg gcaaacatga    900

agagaaacag caagaaggtg gcattgtttc taagaacttc acaaagaaaa tccagcttcc    960

tgcagaggtg gatcctgtga cagtatttgc ctcactttcc ccagagggtc tgctgatcat   1020

cgaagctccc caggtccctc cttactcaac atttggagag agcagtttca acaacgagct   1080

tccccaggac agccaggaag tcacctgtac ctgagatgcc agtactggcc catccttgtt   1140

ttgtccccaa ccctagggct tctctgattc caggatacat tactttagct gaactcagat   1200

ttagtgcaag taaaatgtta gagggtgcgg gggtgaggac tgaccacaga ttccctggat   1260

agtgtagtgg tagatttctc cacaggatag cgcaattggc aaatcatgct tggttgtgtt   1320

aggccaaaat actagttttg ctttctttac cttttctatc ttgatgaaaa tgttgcacat   1380

tctatagttg caaaacacat aaaaggggac ttaacatttc acgttgtatc ttacttgcag   1440

tgaatgcaag ggttactttt ctctggggac ctcccccatc acccaggttc ctactctggg   1500

ctcccgattc ccatggctcc caaaccatgc cgcatggttt ggttaatgaa acccagtagc   1560

taaccccact gtgcttccac atgcctggcc taaaatgggt gatatacagg tcttatatcc   1620

ccatatggaa tttatccatc aaccacataa aaacaaacag tgccttctgc cctctgccca   1680

gatgtgtcca gcacgttctc aaagtttcca cattagcact ccctaaggac gctgggagcc   1740

tgtcagttta tgatctgacc taggtccccc ctttcttctg tcccctgtgt ttaagtcggg   1800

atttttacag agggagctgt ctccagacag ctccatcagg aaccaagcaa aggccagata   1860

gcctgacaga taggctagtg gtattgtgta tatgggcggg acgtgtgtgt cattattatt   1920

tgagttatgc tgttgtttag gggtaaataa cagtaaataa ttaataataa taataataat   1980

aataaaggag ctgacgttct taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2040

aaaaaaaaaa aaaaaa                                                   2056


<210>  3041
<211>  196
<212>  PRT
<213>  Homosapiens

<400>  3041

Met Ala Asp Gly Gln Met Pro Phe Ser Cys His Tyr Pro Ser Arg Leu 
1               5                   10                  15      


Arg Arg Asp Pro Phe Arg Asp Ser Pro Leu Ser Ser Arg Leu Leu Asp 
            20                  25                  30          


Asp Gly Phe Gly Met Asp Pro Phe Pro Asp Asp Leu Thr Ala Ser Trp 
        35                  40                  45              


Pro Asp Trp Ala Leu Pro Arg Leu Ser Ser Ala Trp Pro Gly Thr Leu 
    50                  55                  60                  


Arg Ser Gly Met Val Pro Arg Gly Pro Thr Ala Thr Ala Arg Phe Gly 
65                  70                  75                  80  


Val Pro Ala Glu Gly Arg Thr Pro Pro Pro Phe Pro Gly Glu Pro Trp 
                85                  90                  95      


Lys Val Cys Val Asn Val His Ser Phe Lys Pro Glu Glu Leu Met Val 
            100                 105                 110         


Lys Thr Lys Asp Gly Tyr Val Glu Val Ser Gly Lys His Glu Glu Lys 
        115                 120                 125             


Gln Gln Glu Gly Gly Ile Val Ser Lys Asn Phe Thr Lys Lys Ile Gln 
    130                 135                 140                 


Leu Pro Ala Glu Val Asp Pro Val Thr Val Phe Ala Ser Leu Ser Pro 
145                 150                 155                 160 


Glu Gly Leu Leu Ile Ile Glu Ala Pro Gln Val Pro Pro Tyr Ser Thr 
                165                 170                 175     


Phe Gly Glu Ser Ser Phe Asn Asn Glu Leu Pro Gln Asp Ser Gln Glu 
            180                 185                 190         


Val Thr Cys Thr 
        195     


<210>  3042
<211>  2060
<212>  DNA
<213>  Homosapiens

<400>  3042
ctggcttcgg cctcagcccc accatggtga cgcttgctga actgctggtg ctcctggccg     60

ctctcctggc cacggtctcg ggctatttcg ttagcatcga cgcccatgct gaagagtgct    120

tctttgagcg ggtcacctcg ggcaccaaga tgggcctcat cttcgaggtg gcggagggcg    180

gcttcctgga catcgacgtg gagattacag gaccagataa caaaggaatt tacaaaggag    240

acagagaatc cagtgggaaa tacacatttg ctgctcacat ggatggaaca tacaaatttt    300

gttttagtaa ccggatgtcc accatgactc caaaaatagt gatgttcacc attgatattg    360

gggaggctcc aaaaggacaa gatatggaaa cagaagctca ccagaacaag ctagaagaaa    420

tgatcaatga gctagcagtg gcgatgacag ctgtaaagca cgaacaggaa tacatggaag    480

tccgggagag aatacacaga gccatcaacg acaacacaaa cagcagagtg gtcctttggt    540

ccttctttga agctcttgtt ctagttgcca tgacattggg acagatctac tacctgaaga    600

gattttttga agtccggaga gttgtttaaa aagcctcttc ctgatgatcc caactcagaa    660

ttcactgttt accaaacacc ttggtcataa taatgtcatt agtttctcca tttttatttt    720

ctgaactgta cattcacaac ttatgtttct ttgagattaa tagatattgg gggaaaaacg    780

cctttttagg aaaattatag tgaaaatttg acagttgatt ggcataattt cttgtttgaa    840

tgctgcctcc attatatagg tccttccagg aactcaaaca ctgtaagtga aatatgggag    900

tatagttttt attatttctt cttttccttt tgttttcata atataatgca gtttgttcag    960

gaaatcagca caaagcctga tagtacttta ctaaaatgac tgcattcttt ggattccttc   1020

agtctatggt tcaagtcact aaagattcat ttttgttgag tccttatgag aaacagcagt   1080

atgaatcttg acggtttctg cccgtcctaa tggcagagct ctctgacttg ggtgtatgct   1140

gccaggctgg gtactttcat actttgtttt cttgttttgc tttaaaacta cgactcagca   1200

tacattttcc cacatacatt tttacattgt accttaggac tcagtcatct ccacttaaat   1260

tgatgacaca agcagctaat aaccatttct gggtttctgc ctaaccccct aattgtctgt   1320

taaagccaat tctctgggtg tcccagtgag tggtggcttt ttttctttcc acattggcac   1380

attcacttct cccactcttg gcatgtaaga aataagcatt tacataattg gaaaaatctg   1440

gatttctgat gccaaagggt taaagcttct tggatttcat ttcattgata tacagccact   1500

attttatttt tgatcagtgg cctttgggcc actgttcagg gtactgacca tcagtgtcag   1560

cattagggtt ttggtttttg tttcttttgg gtatttcttt tttggcacat gtgaatcttg   1620

ttttgtgtaa aatgaaatta ctttctcttg ttctctgatg atgggtttaa aattaaaaga   1680

gcatccggtt ttggtatggg gatgatccag gattatgttg tgactgatac atattagtta   1740

cttgtgcttt tttttttttt ttttggatct ttgcaagggc aaaactacaa gtaacgagtt   1800

ttatataatt aatttaaatt tgttacaggt tttcatgttc aggataaacc atacttccac   1860

cttgggtgag aacacttgca acagtttatt aatgaggtga ctttcacctt aggacaactg   1920

ttgcatgcca agttttttgt gtgtgtgaaa cacttcaaaa ctgatttaaa agatgtaaat   1980

ttaaaattgg ttgtatctaa tatgccccag gttcggtaaa taaacaattc tttttaaaaa   2040

aaaaaaaaaa aaaaaaaaaa                                               2060


<210>  3043
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  3043

Met Val Thr Leu Ala Glu Leu Leu Val Leu Leu Ala Ala Leu Leu Ala 
1               5                   10                  15      


Thr Val Ser Gly Tyr Phe Val Ser Ile Asp Ala His Ala Glu Glu Cys 
            20                  25                  30          


Phe Phe Glu Arg Val Thr Ser Gly Thr Lys Met Gly Leu Ile Phe Glu 
        35                  40                  45              


Val Ala Glu Gly Gly Phe Leu Asp Ile Asp Val Glu Ile Thr Gly Pro 
    50                  55                  60                  


Asp Asn Lys Gly Ile Tyr Lys Gly Asp Arg Glu Ser Ser Gly Lys Tyr 
65                  70                  75                  80  


Thr Phe Ala Ala His Met Asp Gly Thr Tyr Lys Phe Cys Phe Ser Asn 
                85                  90                  95      


Arg Met Ser Thr Met Thr Pro Lys Ile Val Met Phe Thr Ile Asp Ile 
            100                 105                 110         


Gly Glu Ala Pro Lys Gly Gln Asp Met Glu Thr Glu Ala His Gln Asn 
        115                 120                 125             


Lys Leu Glu Glu Met Ile Asn Glu Leu Ala Val Ala Met Thr Ala Val 
    130                 135                 140                 


Lys His Glu Gln Glu Tyr Met Glu Val Arg Glu Arg Ile His Arg Ala 
145                 150                 155                 160 


Ile Asn Asp Asn Thr Asn Ser Arg Val Val Leu Trp Ser Phe Phe Glu 
                165                 170                 175     


Ala Leu Val Leu Val Ala Met Thr Leu Gly Gln Ile Tyr Tyr Leu Lys 
            180                 185                 190         


Arg Phe Phe Glu Val Arg Arg Val Val 
        195                 200     


<210>  3044
<211>  2638
<212>  DNA
<213>  Homosapiens

<400>  3044
accgacgcgg cgaaggagcg cgccatggag catgtgacag agggctcctg ggagtcgctg     60

cctgtgccgc tgcacccgca ggtgctgggc gcgctgcggg agctgggctt cccgtacatg    120

acgccggtgc agtccgcaac catccctctg ttcatgcgaa acaaagatgt cgctgcagaa    180

gcggtcacag gtagtggcaa aacactcgct tttgtcatcc ccatcctgga aattcttctg    240

agaagagaag agaagttaaa aaagagtcag gttggagcca taatcatcac ccccactcga    300

gagctggcca ttcaaataga cgaggtcctg tcgcatttca cgaagcactt ccccgagttc    360

agccagattc tttggatcgg aggcaggaat cctggagaag atgttgagag gtttaagcaa    420

caaggtggga acatcattgt ggccactcca ggccgcttgg aggacatgtt ccggaggaag    480

gccgaaggct tggatctggc cagctgtgtg cgatccctgg atgtcctggt gttggatgag    540

gcagacagac ttctggacat ggggtttgag gcaagcatca acaccattct ggagtttttg    600

ccaaagcaga ggagaacagg ccttttctct gccactcaga cgcaggaagt ggagaacctg    660

gtgagagcgg gcctccggaa ccctgtccgg gtctcagtga aggagaaggg cgtggcagcc    720

agcagtgccc agaagacccc ctcccgcctg gaaaactact acatggtatg caaggcagat    780

gagaaattta atcagctggt ccattttctt cgcaatcata agcaggagaa acacctggtc    840

ttcttcagca cctgtgcctg tgtggaatac tatgggaagg ctctggaagt gctggtgaag    900

ggcgtgaaga ttatgtgcat tcacggaaag atgaaatata aacgcaataa gatcttcatg    960

gagttccgca aattgcaaag tgggatttta gtgtgcactg atgtgatggc ccggggaatt   1020

gatattcctg aagtcaactg ggttttgcag tatgaccctc ccagcaatgc aagtgccttc   1080

gtgcatcgct gcggtcgcac agctcgcatt ggccacgggg gcagcgctct ggtgttcctc   1140

ctgcccatgg aagagtcata catcaatttc cttgcaatta accaaaaatg ccccctgcag   1200

gagatgaagc cccagagaaa cacagcggac cttctgccaa aactcaagtc catggccctg   1260

gctgacagag ctgtgtttga aaagggcatg aaagcttttg tgtcatatgt ccaagcttat   1320

gcaaagcatg aatgcaacct gattttcaga ttaaaggatc ttgattttgc cagccttgct   1380

cgaggttttg ccctgctgag gatgcccaag atgccagaat tgagaggaaa gcagtttcca   1440

gattttgtgc ccgtggacgt taataccgac acgattccat ttaaagataa aatcagagaa   1500

aagcagaggc agaaactcct ggagcaacaa agaagagaga aaacagaaaa tgaagggaga   1560

agaaaattca taaaaaataa agcttggtca aagcagaagg ccaaaaaaga aaagaagaaa   1620

aaaatgaatg agaaaaggaa aagggaagag ggttctgata ttgaagatga ggacatggaa   1680

gaacttctta atgacacaag actcttgaaa aaacttaaga aaggcaaaat aactgaagaa   1740

gaatttgaga agggcttgtt gacaactggc aaaagaacaa tcaagacagt ggatttaggg   1800

atctcagatt tggaagatga ctgctgattc cagtgccaca gatgaaccca caaggacata   1860

gctgttccct aacttggtgg atggctccag tttgctttta acgaaaatca caacttcagg   1920

agacatctga aaagaatgat gtctctgaaa gctgtccttt cagatgaggg agaaatgaag   1980

gatttcacac ttcagaatat tttactaaaa acattccagt cttggccggg tgcggtggct   2040

cctgcctata atcccagcac tttgggaggc tgaggcagga ggatcacttg agcccaggag   2100

ttcaagacca gcctgggaac acagcgagac cctctcatta aaaacaacaa aacaaaacaa   2160

ttccagtctt ggagtagtct aacagaagaa aatgtaaaat tatttgagtg taaataatag   2220

atgtcagtat ttatcatgat gggtcacata tagacatatg tacatattat atatatatat   2280

atatatatat atatatatat atatatatat atataagctc ttttttctga ggctatttta   2340

tagttatttt taaacataaa gatacagaag tcttcttgac ttctgatttt caaaaccatt   2400

cctcagtatc ttcaggcatt tgacctcctg aatgtgcttg gccctgggct tcagttatcc   2460

tttgatgtcc tgcaggggtg gctaatgtgc tggggttttt ctgtgttaat agtcacagta   2520

ttgttttatt ggtgaatagc tgaaaaacag agggattaag tcatattccg ggaaagagaa   2580

ttatagtttt tatgcctcct gttgaataaa tggtgtcctg ataaaaaaaa aaaaaaaa     2638


<210>  3045
<211>  600
<212>  PRT
<213>  Homosapiens

<400>  3045

Met Glu His Val Thr Glu Gly Ser Trp Glu Ser Leu Pro Val Pro Leu 
1               5                   10                  15      


His Pro Gln Val Leu Gly Ala Leu Arg Glu Leu Gly Phe Pro Tyr Met 
            20                  25                  30          


Thr Pro Val Gln Ser Ala Thr Ile Pro Leu Phe Met Arg Asn Lys Asp 
        35                  40                  45              


Val Ala Ala Glu Ala Val Thr Gly Ser Gly Lys Thr Leu Ala Phe Val 
    50                  55                  60                  


Ile Pro Ile Leu Glu Ile Leu Leu Arg Arg Glu Glu Lys Leu Lys Lys 
65                  70                  75                  80  


Ser Gln Val Gly Ala Ile Ile Ile Thr Pro Thr Arg Glu Leu Ala Ile 
                85                  90                  95      


Gln Ile Asp Glu Val Leu Ser His Phe Thr Lys His Phe Pro Glu Phe 
            100                 105                 110         


Ser Gln Ile Leu Trp Ile Gly Gly Arg Asn Pro Gly Glu Asp Val Glu 
        115                 120                 125             


Arg Phe Lys Gln Gln Gly Gly Asn Ile Ile Val Ala Thr Pro Gly Arg 
    130                 135                 140                 


Leu Glu Asp Met Phe Arg Arg Lys Ala Glu Gly Leu Asp Leu Ala Ser 
145                 150                 155                 160 


Cys Val Arg Ser Leu Asp Val Leu Val Leu Asp Glu Ala Asp Arg Leu 
                165                 170                 175     


Leu Asp Met Gly Phe Glu Ala Ser Ile Asn Thr Ile Leu Glu Phe Leu 
            180                 185                 190         


Pro Lys Gln Arg Arg Thr Gly Leu Phe Ser Ala Thr Gln Thr Gln Glu 
        195                 200                 205             


Val Glu Asn Leu Val Arg Ala Gly Leu Arg Asn Pro Val Arg Val Ser 
    210                 215                 220                 


Val Lys Glu Lys Gly Val Ala Ala Ser Ser Ala Gln Lys Thr Pro Ser 
225                 230                 235                 240 


Arg Leu Glu Asn Tyr Tyr Met Val Cys Lys Ala Asp Glu Lys Phe Asn 
                245                 250                 255     


Gln Leu Val His Phe Leu Arg Asn His Lys Gln Glu Lys His Leu Val 
            260                 265                 270         


Phe Phe Ser Thr Cys Ala Cys Val Glu Tyr Tyr Gly Lys Ala Leu Glu 
        275                 280                 285             


Val Leu Val Lys Gly Val Lys Ile Met Cys Ile His Gly Lys Met Lys 
    290                 295                 300                 


Tyr Lys Arg Asn Lys Ile Phe Met Glu Phe Arg Lys Leu Gln Ser Gly 
305                 310                 315                 320 


Ile Leu Val Cys Thr Asp Val Met Ala Arg Gly Ile Asp Ile Pro Glu 
                325                 330                 335     


Val Asn Trp Val Leu Gln Tyr Asp Pro Pro Ser Asn Ala Ser Ala Phe 
            340                 345                 350         


Val His Arg Cys Gly Arg Thr Ala Arg Ile Gly His Gly Gly Ser Ala 
        355                 360                 365             


Leu Val Phe Leu Leu Pro Met Glu Glu Ser Tyr Ile Asn Phe Leu Ala 
    370                 375                 380                 


Ile Asn Gln Lys Cys Pro Leu Gln Glu Met Lys Pro Gln Arg Asn Thr 
385                 390                 395                 400 


Ala Asp Leu Leu Pro Lys Leu Lys Ser Met Ala Leu Ala Asp Arg Ala 
                405                 410                 415     


Val Phe Glu Lys Gly Met Lys Ala Phe Val Ser Tyr Val Gln Ala Tyr 
            420                 425                 430         


Ala Lys His Glu Cys Asn Leu Ile Phe Arg Leu Lys Asp Leu Asp Phe 
        435                 440                 445             


Ala Ser Leu Ala Arg Gly Phe Ala Leu Leu Arg Met Pro Lys Met Pro 
    450                 455                 460                 


Glu Leu Arg Gly Lys Gln Phe Pro Asp Phe Val Pro Val Asp Val Asn 
465                 470                 475                 480 


Thr Asp Thr Ile Pro Phe Lys Asp Lys Ile Arg Glu Lys Gln Arg Gln 
                485                 490                 495     


Lys Leu Leu Glu Gln Gln Arg Arg Glu Lys Thr Glu Asn Glu Gly Arg 
            500                 505                 510         


Arg Lys Phe Ile Lys Asn Lys Ala Trp Ser Lys Gln Lys Ala Lys Lys 
        515                 520                 525             


Glu Lys Lys Lys Lys Met Asn Glu Lys Arg Lys Arg Glu Glu Gly Ser 
    530                 535                 540                 


Asp Ile Glu Asp Glu Asp Met Glu Glu Leu Leu Asn Asp Thr Arg Leu 
545                 550                 555                 560 


Leu Lys Lys Leu Lys Lys Gly Lys Ile Thr Glu Glu Glu Phe Glu Lys 
                565                 570                 575     


Gly Leu Leu Thr Thr Gly Lys Arg Thr Ile Lys Thr Val Asp Leu Gly 
            580                 585                 590         


Ile Ser Asp Leu Glu Asp Asp Cys 
        595                 600 


<210>  3046
<211>  1794
<212>  DNA
<213>  Homosapiens

<400>  3046
aggggtacgg aagtgcgccg gaagtggggt gcggaggtgt gcagcgcgct gtcagactgg     60

ctcgcaggcg gcgcggccgg cggacccgtt cgagacagcg cgggcggctc gggtcccctg    120

gggctccgca gcaggaggac gccatggacg acaaggagtt aattgaatac tttaagtctc    180

agatgaaaga agatcctgac atggcctcag cagtggctgc catccggacg ttgctggagt    240

tcttgaagag agataaaggg gagacaatcc agggtctgag ggcgaatctc accagtgcca    300

tagaaaccct gtgtggtgtg gactcctctg tggcagtgtc ctctggcggg gagctcttcc    360

tccgcttcat cagtcttgcc tccctggaat actccgatta ctccaaatgt aaaaagatca    420

tgattgagcg gggagaactt tttctcagga gaatatcact gtcaagaaac aaaattgcag    480

atctgtgcca tactttcatc aaagatggag cgacaatatt gactcacgcc tactccagag    540

tggtcctgag agtcctggaa gcagccgtgg cggccaagaa gcgatttagt gtatacgtca    600

cagagtcaca gcctgatttg tcaggtaaga aaatggccaa agccctctgc cacctcaacg    660

tccctgtcac tgtggtgcta gatgctgctg tcggctacat catggagaaa gcagatcttg    720

tcatagttgg tgctgaagga gttgttgaaa acggaggaat tattaacaag attggaacca    780

accagatggc tgtgtgtgcc aaagcacaga acaaaccttt ctatgtggtt gcagaaagtt    840

tcaagtttgt ccggctcttt ccactaaacc agcaagacgt cccagataag tttaagtata    900

aggcagacac tctcaaggtc gcgcagactg gacaagacct caaagaggag catccgtggg    960

tcgactacac tgccccttcc ttaatcactc tgctgtttac agacctgggc gtgctgacac   1020

cctcagcagt cagcgatgag ctcatcaagc tctatctgta acctgtgagc cctttcctgc   1080

caaggtgcag cttacgtagt tgaggcaggg tgagtagctg cttgacaccc cagtgagtca   1140

ggccaaaact gagatgtgtt taatgaagat ttatggagta aggacttaaa atcatacatc   1200

ttggagaacc tttcttactc atttcagtcc catctaaaaa tgtgtcagct attctaaatc   1260

ccaacttaaa ttgttcttac ggtttctaga aactttcctt ttcagtttcc agaaatacaa   1320

gttagataat tggctactta actgatgaaa gatgagccca agtccacctg tcttcatcct   1380

cccctgcact ccagactgat ctgcctaaag cacgcgagat gcaggcgaaa agcagccaca   1440

cccctctgcc acaaatgacc aacagctggt caggacgtta cacgcggtgc cttgtaagag   1500

gcaagaaaca cttgctgaat ctgcatctgg cttccagtgg taagcacatt cctcagcagg   1560

atcaagccaa acagtaaaaa ctaccaagag aacacgagga aggcagaaac gatgtttagc   1620

aacagtattc tgcatggttc actgcttaag aaaatgcctt ctggaatatt tgtaaactga   1680

aattctgtat gtgtaagaga tgtttaaata tgtttgggtc ctaaacagct ttttaaaatt   1740

atacttggga ataaattcag catcttttca aataaactct atgaaagacg ctga         1794


<210>  3047
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  3047

Met Asp Asp Lys Glu Leu Ile Glu Tyr Phe Lys Ser Gln Met Lys Glu 
1               5                   10                  15      


Asp Pro Asp Met Ala Ser Ala Val Ala Ala Ile Arg Thr Leu Leu Glu 
            20                  25                  30          


Phe Leu Lys Arg Asp Lys Gly Glu Thr Ile Gln Gly Leu Arg Ala Asn 
        35                  40                  45              


Leu Thr Ser Ala Ile Glu Thr Leu Cys Gly Val Asp Ser Ser Val Ala 
    50                  55                  60                  


Val Ser Ser Gly Gly Glu Leu Phe Leu Arg Phe Ile Ser Leu Ala Ser 
65                  70                  75                  80  


Leu Glu Tyr Ser Asp Tyr Ser Lys Cys Lys Lys Ile Met Ile Glu Arg 
                85                  90                  95      


Gly Glu Leu Phe Leu Arg Arg Ile Ser Leu Ser Arg Asn Lys Ile Ala 
            100                 105                 110         


Asp Leu Cys His Thr Phe Ile Lys Asp Gly Ala Thr Ile Leu Thr His 
        115                 120                 125             


Ala Tyr Ser Arg Val Val Leu Arg Val Leu Glu Ala Ala Val Ala Ala 
    130                 135                 140                 


Lys Lys Arg Phe Ser Val Tyr Val Thr Glu Ser Gln Pro Asp Leu Ser 
145                 150                 155                 160 


Gly Lys Lys Met Ala Lys Ala Leu Cys His Leu Asn Val Pro Val Thr 
                165                 170                 175     


Val Val Leu Asp Ala Ala Val Gly Tyr Ile Met Glu Lys Ala Asp Leu 
            180                 185                 190         


Val Ile Val Gly Ala Glu Gly Val Val Glu Asn Gly Gly Ile Ile Asn 
        195                 200                 205             


Lys Ile Gly Thr Asn Gln Met Ala Val Cys Ala Lys Ala Gln Asn Lys 
    210                 215                 220                 


Pro Phe Tyr Val Val Ala Glu Ser Phe Lys Phe Val Arg Leu Phe Pro 
225                 230                 235                 240 


Leu Asn Gln Gln Asp Val Pro Asp Lys Phe Lys Tyr Lys Ala Asp Thr 
                245                 250                 255     


Leu Lys Val Ala Gln Thr Gly Gln Asp Leu Lys Glu Glu His Pro Trp 
            260                 265                 270         


Val Asp Tyr Thr Ala Pro Ser Leu Ile Thr Leu Leu Phe Thr Asp Leu 
        275                 280                 285             


Gly Val Leu Thr Pro Ser Ala Val Ser Asp Glu Leu Ile Lys Leu Tyr 
    290                 295                 300                 


Leu 
305 


<210>  3048
<211>  1505
<212>  DNA
<213>  Homosapiens

<400>  3048
ctctgcgctg aggtgctggg acagccatgg tttcagacga agatgaattg aatcttctgg     60

ttattgtagt tgatgccaac ccaatttggt ggggaaagca agcattaaag gaatctcagt    120

tcactttatc caaatgcata gatgccgtga tggtgctggg aaattcgcat ttattcatga    180

atcgttccaa caaacttgct gtgatagcaa gtcacattca agaaagccga ttcttatatc    240

ctggaaagaa tggcagactt ggagacttct tcggagaccc tggcaaccct cctgaattta    300

atccctctgg gagtaaagat ggaaaatacg aacttttaac ctcagcaaat gaagttattg    360

ttgaagagat taaagatcta atgaccaaaa gtgacataaa gggtcaacat acagaaactt    420

tgctggcagg atccctggcc aaagcccttt gctacattca tagaatgaac aaggaagtta    480

aagacaatca ggaaatgaaa tcaaggatat tggtgattaa ggctgcagaa gacagtgcgt    540

tgcagtatat gaacttcatg aatgtcatct ttgcagcaca gaaacagaat attttgattg    600

atgcctgtgt tttagactcc gactcagggc tcctccaaca ggcttgtgac atcacgggag    660

gactgtacct gaaggtgcct cagatgcctt ctcttctgca gtatttgctg tgggtgtttc    720

ttcccgatca agatcagaga tctcagttaa tcctcccacc cccagttcat gttgactaca    780

gggctgcttg cttctgtcat cgaaatctca ttgaaattgg ttatgtctgt tctgtgtgtt    840

tgtcaatatt ctgcaatttc agccccattt gtactacgtg cgagacagcc tttaaaattt    900

ctctgcctcc agtgctgaaa gccaagaaaa agaaactgaa agtgtctgcc tgaggataaa    960

atattttccc catcttttag agctgttaat agaaattata tagcagattc tttgttggga   1020

agactgaaaa aaataaagat aggtatagga taatttttaa tatggtgacc ttacagaaaa   1080

tatttcccaa acatcctttt catcctgtgc ttctggagga ctgatttgtt tgagggaatc   1140

attctatgca ttatatccta aaatattcta tgactggttt ctgtccatgt ttgtggcttt   1200

cattttttta atgggatgac tattagtcaa agtcagcttg tcatgactca tcataggctt   1260

tctaacctac tccctgaatc cgggtcctca ttgtgaaatg catgccatac gaaatttgaa   1320

cgtagctttg gaaaaaggga ctatttgtgg agtaatggca ttaatcaaca tagaacatct   1380

tatttgaatc aacagttaac ttcagtagtc atgtgaataa aattcttatt gtctaaattg   1440

agacagcctc agatatttgc agatatttac tttttgtctg atatcagtac atatttggac   1500

aaagt                                                               1505


<210>  3049
<211>  308
<212>  PRT
<213>  Homosapiens

<400>  3049

Met Val Ser Asp Glu Asp Glu Leu Asn Leu Leu Val Ile Val Val Asp 
1               5                   10                  15      


Ala Asn Pro Ile Trp Trp Gly Lys Gln Ala Leu Lys Glu Ser Gln Phe 
            20                  25                  30          


Thr Leu Ser Lys Cys Ile Asp Ala Val Met Val Leu Gly Asn Ser His 
        35                  40                  45              


Leu Phe Met Asn Arg Ser Asn Lys Leu Ala Val Ile Ala Ser His Ile 
    50                  55                  60                  


Gln Glu Ser Arg Phe Leu Tyr Pro Gly Lys Asn Gly Arg Leu Gly Asp 
65                  70                  75                  80  


Phe Phe Gly Asp Pro Gly Asn Pro Pro Glu Phe Asn Pro Ser Gly Ser 
                85                  90                  95      


Lys Asp Gly Lys Tyr Glu Leu Leu Thr Ser Ala Asn Glu Val Ile Val 
            100                 105                 110         


Glu Glu Ile Lys Asp Leu Met Thr Lys Ser Asp Ile Lys Gly Gln His 
        115                 120                 125             


Thr Glu Thr Leu Leu Ala Gly Ser Leu Ala Lys Ala Leu Cys Tyr Ile 
    130                 135                 140                 


His Arg Met Asn Lys Glu Val Lys Asp Asn Gln Glu Met Lys Ser Arg 
145                 150                 155                 160 


Ile Leu Val Ile Lys Ala Ala Glu Asp Ser Ala Leu Gln Tyr Met Asn 
                165                 170                 175     


Phe Met Asn Val Ile Phe Ala Ala Gln Lys Gln Asn Ile Leu Ile Asp 
            180                 185                 190         


Ala Cys Val Leu Asp Ser Asp Ser Gly Leu Leu Gln Gln Ala Cys Asp 
        195                 200                 205             


Ile Thr Gly Gly Leu Tyr Leu Lys Val Pro Gln Met Pro Ser Leu Leu 
    210                 215                 220                 


Gln Tyr Leu Leu Trp Val Phe Leu Pro Asp Gln Asp Gln Arg Ser Gln 
225                 230                 235                 240 


Leu Ile Leu Pro Pro Pro Val His Val Asp Tyr Arg Ala Ala Cys Phe 
                245                 250                 255     


Cys His Arg Asn Leu Ile Glu Ile Gly Tyr Val Cys Ser Val Cys Leu 
            260                 265                 270         


Ser Ile Phe Cys Asn Phe Ser Pro Ile Cys Thr Thr Cys Glu Thr Ala 
        275                 280                 285             


Phe Lys Ile Ser Leu Pro Pro Val Leu Lys Ala Lys Lys Lys Lys Leu 
    290                 295                 300                 


Lys Val Ser Ala 
305             


<210>  3050
<211>  2902
<212>  DNA
<213>  Homosapiens

<400>  3050
gcggcggggc agtggctgct gcgttttcgt gtctgagtcc ttcctgggtt ctaatgaggg     60

cgcggttctg ctgtgcccgg cccgcgaggt ctaaggcatg ggcttccagc ctccggccgc    120

tcttcttttg aggcttttcc ttctgcaggg catcctgagg cttctgtggg gggacctggc    180

tttcatccct ccttttatcc gaatgtccgg ccctgcggtc agcgcgtccc tggtcggaga    240

caccgagggt gtgaccgtgt ccctggcagt gctgcaggac gaggcgggaa tattgccaat    300

tccgacgtgt ggagtgctga acaatgagac ggaagactgg agcgtgactg tgatccccgg    360

tgcgaaggtg ttggaagtga cagtgaggtg gaagagaggt ctggactggt gttcctccaa    420

tgagacagat tccttctcag agtccccctg tatcctccag acccttctgg tttcagcatc    480

tcataattca tcctgttcag cacatctact cattcaagtg gaaatttatg ccaactcttc    540

tctgacccat aatgcctcag agaacgtgac tgtcattcct aaccaggtgt atcagcccct    600

tggcccttgt ccttgtaatt taacagctgg agcctgtgat gttcgctgct gctgtgacca    660

ggaatgctca tcaaatttaa caacgctgtt cagacggtcc tgcttcaccg gcgtgtttgg    720

aggagacgtc aatcctcctt ttgatcagct ctgctctgct gggacgacga cacgtggtgt    780

ccccgattgg tttccctttc tgtgtgtgca gtcccccctt gccaacacac ccttccttgg    840

ttacttctat catggtgctg tttcccccaa acaggactct tcctttgaag tatatgtgga    900

tactgacgca aaagactttg cagactttgg ttacaaacaa ggagatccca ttatgactgt    960

aaagaaggca tattttacta ttccgcaggt gtccctggct gggcagtgta tgcagaacgc   1020

cccagtggca tttcttcaca attttgatgt taaatgcgtt actaatttgg aactatacca   1080

agaacgagat ggtattatca atgcgaagat aaagaatgtt gccttaggag gcatagttac   1140

accaaaagtg atctatgagg aagcaactga cctagacaaa ttcatcacca atacagaaac   1200

tcctttaaat aacggatcaa cccctagaat tgtgaatgtg gaagaacatt atattttcaa   1260

atggaataat aataccatca gtgaaataaa tgttaaaatt tttagggcag agattaatgc   1320

ccaccagaaa gggataatga cacagagatt tgtagtaaaa tttttaagct ataatagtgg   1380

taatgaagaa gaattatctg gaaatccagg ttaccaactt ggcaagcctg tccgagctct   1440

aaatatcaac aggatgaata atgtcacgac tttacatctt tggcaatcgg ctggaagggg   1500

tctgtgtaca tcagcaactt tcaaacccat tttatttgga gaaaatgtac tctctggatg   1560

cctgttagaa gtcgggatta atgaaaattg tactcagctc agggagaatg ctgttgaaag   1620

acttgattca ttaatacaag cgactcacgt tgcaatgaga ggcaactccg attacgctga   1680

tcttagtgat ggctggctcg aaataatacg tgtagatgcc cctgatccag gtgcagaccc   1740

gctggctagc agtgtgaacg gcatgtgcct ggatattcct gctcacctga gcatccgcat   1800

cctcatctcg gatgctggcg cggtggaagg gattactcag caggagatac tcggtgtaga   1860

gacaaggttc tcctcagtga actggcagta ccagtgtggg cttacctgtg agcacaaggc   1920

cgaccttctc cctatcagtg catccgtcca gtttattaaa attcctgcac agttacccca   1980

ccccctgaca agattccaga tcaattatac agagtatgac tgcaacagaa atgaggtgtg   2040

ttggccgcag cttctatatc catggactca gtattatcaa ggggagctgc attctcagtg   2100

tgttgctaag ggcttactgt tgctgttgtt cctcacattg gccttgttcc tcagcaaccc   2160

ctggaccaga atatgcaaag cctatagtta gacaaccacc tggcttttat ttttttgaga   2220

tggagttttg ctcttgttgc ccaggctgaa gtgatctcgg ctcaccacaa cctcctcctc   2280

ttgggttcaa gcgattctcc tgcctcagcc tccggagaac tgggattaca ggcatgcacc   2340

accacgcccg gctaattttg tatttttagt agagacaggg ttccaccgta ttggccaggc   2400

tgctctcgaa ctcctgacct catgatccgc ccatcttggc ctcccaaagt gctgagatta   2460

caggcatgag ccaccgcacc cggccttttt tttttttttt tttttttgag gcggggtctc   2520

tgtcacccag gctggagtgc agtgcacaat ctcggctcac tgcaatctct gcctcccaag   2580

caatcctccc acctcagcct ctggtgtagc tgggaccaca gatgctccac catgcctggc   2640

tgtatttttg gtaaagacgg ggtttcgcct tgttgcccag ggtggtctgt aactcctgag   2700

ctcagatgat ctgcccacct cggcctccca aagtgctggg atcacagacg tgagccactg   2760

cgtccggtcc atctgacttc tcaaagactt tagaccttga cttcagtgat ttgttgtagt   2820

cttgtatgct tctctataaa attttaataa atgaaatgtc ttatttttgt agaaaattaa   2880

aaaaaaaaaa aaaaaaaaaa aa                                            2902


<210>  3051
<211>  697
<212>  PRT
<213>  Homosapiens

<400>  3051

Met Gly Phe Gln Pro Pro Ala Ala Leu Leu Leu Arg Leu Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ile Leu Arg Leu Leu Trp Gly Asp Leu Ala Phe Ile Pro Pro 
            20                  25                  30          


Phe Ile Arg Met Ser Gly Pro Ala Val Ser Ala Ser Leu Val Gly Asp 
        35                  40                  45              


Thr Glu Gly Val Thr Val Ser Leu Ala Val Leu Gln Asp Glu Ala Gly 
    50                  55                  60                  


Ile Leu Pro Ile Pro Thr Cys Gly Val Leu Asn Asn Glu Thr Glu Asp 
65                  70                  75                  80  


Trp Ser Val Thr Val Ile Pro Gly Ala Lys Val Leu Glu Val Thr Val 
                85                  90                  95      


Arg Trp Lys Arg Gly Leu Asp Trp Cys Ser Ser Asn Glu Thr Asp Ser 
            100                 105                 110         


Phe Ser Glu Ser Pro Cys Ile Leu Gln Thr Leu Leu Val Ser Ala Ser 
        115                 120                 125             


His Asn Ser Ser Cys Ser Ala His Leu Leu Ile Gln Val Glu Ile Tyr 
    130                 135                 140                 


Ala Asn Ser Ser Leu Thr His Asn Ala Ser Glu Asn Val Thr Val Ile 
145                 150                 155                 160 


Pro Asn Gln Val Tyr Gln Pro Leu Gly Pro Cys Pro Cys Asn Leu Thr 
                165                 170                 175     


Ala Gly Ala Cys Asp Val Arg Cys Cys Cys Asp Gln Glu Cys Ser Ser 
            180                 185                 190         


Asn Leu Thr Thr Leu Phe Arg Arg Ser Cys Phe Thr Gly Val Phe Gly 
        195                 200                 205             


Gly Asp Val Asn Pro Pro Phe Asp Gln Leu Cys Ser Ala Gly Thr Thr 
    210                 215                 220                 


Thr Arg Gly Val Pro Asp Trp Phe Pro Phe Leu Cys Val Gln Ser Pro 
225                 230                 235                 240 


Leu Ala Asn Thr Pro Phe Leu Gly Tyr Phe Tyr His Gly Ala Val Ser 
                245                 250                 255     


Pro Lys Gln Asp Ser Ser Phe Glu Val Tyr Val Asp Thr Asp Ala Lys 
            260                 265                 270         


Asp Phe Ala Asp Phe Gly Tyr Lys Gln Gly Asp Pro Ile Met Thr Val 
        275                 280                 285             


Lys Lys Ala Tyr Phe Thr Ile Pro Gln Val Ser Leu Ala Gly Gln Cys 
    290                 295                 300                 


Met Gln Asn Ala Pro Val Ala Phe Leu His Asn Phe Asp Val Lys Cys 
305                 310                 315                 320 


Val Thr Asn Leu Glu Leu Tyr Gln Glu Arg Asp Gly Ile Ile Asn Ala 
                325                 330                 335     


Lys Ile Lys Asn Val Ala Leu Gly Gly Ile Val Thr Pro Lys Val Ile 
            340                 345                 350         


Tyr Glu Glu Ala Thr Asp Leu Asp Lys Phe Ile Thr Asn Thr Glu Thr 
        355                 360                 365             


Pro Leu Asn Asn Gly Ser Thr Pro Arg Ile Val Asn Val Glu Glu His 
    370                 375                 380                 


Tyr Ile Phe Lys Trp Asn Asn Asn Thr Ile Ser Glu Ile Asn Val Lys 
385                 390                 395                 400 


Ile Phe Arg Ala Glu Ile Asn Ala His Gln Lys Gly Ile Met Thr Gln 
                405                 410                 415     


Arg Phe Val Val Lys Phe Leu Ser Tyr Asn Ser Gly Asn Glu Glu Glu 
            420                 425                 430         


Leu Ser Gly Asn Pro Gly Tyr Gln Leu Gly Lys Pro Val Arg Ala Leu 
        435                 440                 445             


Asn Ile Asn Arg Met Asn Asn Val Thr Thr Leu His Leu Trp Gln Ser 
    450                 455                 460                 


Ala Gly Arg Gly Leu Cys Thr Ser Ala Thr Phe Lys Pro Ile Leu Phe 
465                 470                 475                 480 


Gly Glu Asn Val Leu Ser Gly Cys Leu Leu Glu Val Gly Ile Asn Glu 
                485                 490                 495     


Asn Cys Thr Gln Leu Arg Glu Asn Ala Val Glu Arg Leu Asp Ser Leu 
            500                 505                 510         


Ile Gln Ala Thr His Val Ala Met Arg Gly Asn Ser Asp Tyr Ala Asp 
        515                 520                 525             


Leu Ser Asp Gly Trp Leu Glu Ile Ile Arg Val Asp Ala Pro Asp Pro 
    530                 535                 540                 


Gly Ala Asp Pro Leu Ala Ser Ser Val Asn Gly Met Cys Leu Asp Ile 
545                 550                 555                 560 


Pro Ala His Leu Ser Ile Arg Ile Leu Ile Ser Asp Ala Gly Ala Val 
                565                 570                 575     


Glu Gly Ile Thr Gln Gln Glu Ile Leu Gly Val Glu Thr Arg Phe Ser 
            580                 585                 590         


Ser Val Asn Trp Gln Tyr Gln Cys Gly Leu Thr Cys Glu His Lys Ala 
        595                 600                 605             


Asp Leu Leu Pro Ile Ser Ala Ser Val Gln Phe Ile Lys Ile Pro Ala 
    610                 615                 620                 


Gln Leu Pro His Pro Leu Thr Arg Phe Gln Ile Asn Tyr Thr Glu Tyr 
625                 630                 635                 640 


Asp Cys Asn Arg Asn Glu Val Cys Trp Pro Gln Leu Leu Tyr Pro Trp 
                645                 650                 655     


Thr Gln Tyr Tyr Gln Gly Glu Leu His Ser Gln Cys Val Ala Lys Gly 
            660                 665                 670         


Leu Leu Leu Leu Leu Phe Leu Thr Leu Ala Leu Phe Leu Ser Asn Pro 
        675                 680                 685             


Trp Thr Arg Ile Cys Lys Ala Tyr Ser 
    690                 695         


<210>  3052
<211>  4681
<212>  DNA
<213>  Homosapiens

<400>  3052
gggggcggaa ccggaaccgg cagtggcttg ggggcgggac ctcgcggact gctgtggcgg     60

cagctggagc ggcggccgcg gtggcagaac cgggggcggc cgctgcagtc tggagcccca    120

tagtgcgggg ccgcggccag gccacaggaa gagctcgagg cccgggccgc accggctgag    180

tgtgcgggcc cgcgcggctc ggagccgccg ccgcccatcg agcccctccg ggcgcgggtc    240

ggcccgccat ggggtccctg ttccggagcg agaccatgtg cctggcgcag ctcttcctgc    300

agtcgggcac ggcctacgag tgcctcagcg ccctgggcga gaaaggcctg gtccagttcc    360

gagacctcaa ccagaacgta agttctttcc aaagaaaatt tgttggtgag gtgaagaggt    420

gtgaagagct agagcgaata ttggtgtatt tggtacagga aattaataga gctgatattc    480

cccttcctga aggagaggcc agccctcctg cgccacccct gaaacaggtt ctagaaatgc    540

aggagcagtt gcagaagctc gaggttgaac tgagagaagt cactaagaac aaggagaaac    600

tgaggaaaaa cttgctggaa ctgatagagt acactcacat gctgagagtg acaaagacct    660

ttgtgaaacg caatgttgag tttgaaccca cttatgaaga attcccttcc ttagagagtg    720

attctttgtt ggattacagc tgtatgcaga ggctgggagc aaaactggga tttgtgtctg    780

gcctaattaa ccaaggaaaa gtggaagcat ttgaaaaaat gttgtggaga gtctgcaaag    840

ggtacaccat cgtgtcctat gcagaactgg atgaatccct tgaagaccct gaaacagggg    900

aagtcataaa atggtatgtc tttttaatat ccttttgggg agagcagatt ggccacaagg    960

ttaagaagat atgtgattgc taccactgcc acgtgtaccc ctatccaaac acagccgagg   1020

agcggaggga gatccaggag gggctgaaca cccgcatcca ggatctctac actgtactgc   1080

acaaaaccga ggactatttg aggcaagtgc tatgtaaagc cgccgagtct gtctacagcc   1140

gtgtgatcca ggtgaagaaa atgaaggcca tctatcacat gctgaacatg tgcagctttg   1200

acgtgaccaa caagtgcctc attgctgagg tctggtgtcc cgaggcggat ctgcaggacc   1260

tgcgccgggc actggaggag ggctcgagag agagtggtgc tacaatcccc tcattcatga   1320

atataatccc cacaaaagaa acacccccca ctcggatccg caccaacaaa ttcaccgagg   1380

gatttcagaa catcgtggat gcttatggag tcggaagcta cagagaagtc aatccagctc   1440

tctttaccat catcaccttc ccgtttttat ttgctgtgat gtttggagac ttcggacatg   1500

gctttgtgat gtttttattt gccctcttgt tggtgttaaa tgaaaatcat cccagactaa   1560

atcagtcaca agagatcatg aggatgtttt ttaatggccg gtacatcctc ctgctgatgg   1620

ggctgttctc agtgtacact ggcctcatct acaacgactg cttttcaaag tcagtcaacc   1680

tgttcggctc tgggtggaac gtgtcggcca tgtacagctc cagccaccca cccgcagagc   1740

ataagaagat ggtgctttgg aatgacagcg tcgttagaca caacagcatt ttgcagctgg   1800

atccaagcat tcctggagtg ttccgaggcc cttatcccct tggcattgat cctatttgga   1860

acttggccac aaatcgcctc acttttctaa actctttcaa aatgaaaatg tccgtgattt   1920

taggaatcat tcatatgact tttggagtca ttctgggaat atttaaccac ttgcacttca   1980

ggaagaagtt caacatttac ctggtttcca tcccggaact tctcttcatg ctctgtatct   2040

ttggatacct tatatttatg attttctaca agtggctggt tttttcagca gaaacctcca   2100

gagttgctcc cagcattctg attgaattta ttaacatgtt tttattccca gccagtaaaa   2160

caagtggcct ttacacaggg caggagtatg tccagagagt gctgctggtt gtcacagcat   2220

tgtctgtccc tgtcctcttc ttgggaaagc cactgttttt gttgtggctt cacaatgggc   2280

gtagttgctt cggggtgaac cggagtggct acacacttat aaggaaagat agtgaggaag   2340

aagtttcatt gctgggaagc caagatatag aagagggaaa tcaccaggtg gaagatggat   2400

gtagagaaat ggcgtgtgaa gagtttaatt ttggagaaat attaatgacc caagtaatcc   2460

attccatcga gtactgtctg ggatgcatct ccaacaccgc ctcctacctg aggctctggg   2520

cgcttagcct ggctcacgca cagttgtctg atgtcctgtg ggccatgctg atgcgcgtgg   2580

gcctccgcgt tgacaccacc tatggcgtct tgctactgct cccggttatc gcgctctttg   2640

cagttttgac cattttcatc cttctgatca tggaagggct ttctgcgttt cttcacgcca   2700

tacgcctcca ctgggtagaa tttcagaaca aattctacgt tggtgcaggc accaaatttg   2760

ttcctttctc attcagtcta ctttcatcaa agttcaataa cgacgacagt gtggcatgat   2820

catattgctg taaccaacaa gctttcagat ttatggagaa tgaccatgtt atagactttc   2880

acttatgtca gatttatgat aggaaaaatt ccatcttcat tactgcctta tgacatagcc   2940

aaataattct gtaagatata cctcttcctc atatgttaaa tattttgtaa agtttaccaa   3000

tttgagatat aaaaatttct tttggttttt tatgatgagc aaatataagt taatgccaaa   3060

cgttatgtta aagttatttt ttcaaataca ggatttgggg agagaagcca attttgcatg   3120

gctagttgaa aatggtatta gatacttatt tcctttaaac tttatttaaa acaaacaaca   3180

gagttaatct gtcacctgaa gttgccagat aatattttcc aacagctgaa gtagggatag   3240

ttttttaaaa aatttaatga tgggtaatca aaacattcac atttattctg ctggatttaa   3300

aaatatgtac tttttttttt tttttgagat gaagtcttgc tgtgtcacgt aggctggagt   3360

gcaatggcac gatcgtgtct cattgcaact tccgcctcct ggattcaggt gattctcctg   3420

tctcagcctc ccgagtaact gggattacag gcatgcgcca ccgtgaccag ctaatttttt   3480

tgtatttttg tagagatggg gtttcaccat gttggccagg ctggtctcga acttctgacc   3540

tcaagtgatc cacctgcctc ggcctcccta agtgctggga ttacaggcgt gagccaccat   3600

gcctggccaa aatatgcaaa tattttttat cctgtgctac ctagaattac aagtagagga   3660

ttgtttttac aattttgtct tgttttagta attggggaca atgggataaa atgacataca   3720

acaaatggtt atcccacttg tatatttttt taaagactct tatcctgtta cccttacata   3780

aaaccagtta tgataattgt atgtttggaa gataaattgt atgctgagcc ttaaaaccca   3840

gtgtgactgt agaagatata atgcggacat gatttgaatt tagtgacagc ttggctgatg   3900

tcactgaacc agaagggttt atactgagtg aaggaaaggt aaaaagtagt attttgtata   3960

tttttgtaac aaaatataaa tgaagatatt ttaccatgaa gagattgcac ttatccttga   4020

gaacagtcta aatataaatg aagatatttt accatgaaga gattgcactt atccttgaga   4080

acagtctaat gatacttttt ttactttcag actgtttcta gctaaagttc tgataaaagt   4140

attgagttaa tttaaacttt caaacactgt ttagatcagt tgaaaactaa ttcttaatag   4200

ccattgtttt ataatcttta gtttaaattc atctgtttga catttggttt tttgtgaact   4260

tgagtcagtc ctattgaaca ttttgaccta tattcttgca aattatgtta atttttcata   4320

ttttagtttg attttagaca attattttca aaaagaaacc tgactttttt tcaccttctt   4380

gacattgtga gtgatacacg ttaaaaggct atttgcccgc atcctcctct atcctgtttc   4440

gaggtagaga gcttggcact tctgttacaa gctgagagtc tggaggtgct gagtttaacg   4500

tggctgtgca gctgatttca aggcatgagc tgaacagcgt tgacacagcc gtgacttaca   4560

attaaaccct ttcaattaca gtacagattc tgtgtgctac ttgatgagat gttacccaag   4620

gccagtttgg acttactgct ttttgtccct catattaaat tatcaaatga tgccgatgaa   4680

a                                                                   4681


<210>  3053
<211>  856
<212>  PRT
<213>  Homosapiens

<400>  3053

Met Gly Ser Leu Phe Arg Ser Glu Thr Met Cys Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Gly Thr Ala Tyr Glu Cys Leu Ser Ala Leu Gly Glu Lys 
            20                  25                  30          


Gly Leu Val Gln Phe Arg Asp Leu Asn Gln Asn Val Ser Ser Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Gly Glu Val Lys Arg Cys Glu Glu Leu Glu Arg Ile 
    50                  55                  60                  


Leu Val Tyr Leu Val Gln Glu Ile Asn Arg Ala Asp Ile Pro Leu Pro 
65                  70                  75                  80  


Glu Gly Glu Ala Ser Pro Pro Ala Pro Pro Leu Lys Gln Val Leu Glu 
                85                  90                  95      


Met Gln Glu Gln Leu Gln Lys Leu Glu Val Glu Leu Arg Glu Val Thr 
            100                 105                 110         


Lys Asn Lys Glu Lys Leu Arg Lys Asn Leu Leu Glu Leu Ile Glu Tyr 
        115                 120                 125             


Thr His Met Leu Arg Val Thr Lys Thr Phe Val Lys Arg Asn Val Glu 
    130                 135                 140                 


Phe Glu Pro Thr Tyr Glu Glu Phe Pro Ser Leu Glu Ser Asp Ser Leu 
145                 150                 155                 160 


Leu Asp Tyr Ser Cys Met Gln Arg Leu Gly Ala Lys Leu Gly Phe Val 
                165                 170                 175     


Ser Gly Leu Ile Asn Gln Gly Lys Val Glu Ala Phe Glu Lys Met Leu 
            180                 185                 190         


Trp Arg Val Cys Lys Gly Tyr Thr Ile Val Ser Tyr Ala Glu Leu Asp 
        195                 200                 205             


Glu Ser Leu Glu Asp Pro Glu Thr Gly Glu Val Ile Lys Trp Tyr Val 
    210                 215                 220                 


Phe Leu Ile Ser Phe Trp Gly Glu Gln Ile Gly His Lys Val Lys Lys 
225                 230                 235                 240 


Ile Cys Asp Cys Tyr His Cys His Val Tyr Pro Tyr Pro Asn Thr Ala 
                245                 250                 255     


Glu Glu Arg Arg Glu Ile Gln Glu Gly Leu Asn Thr Arg Ile Gln Asp 
            260                 265                 270         


Leu Tyr Thr Val Leu His Lys Thr Glu Asp Tyr Leu Arg Gln Val Leu 
        275                 280                 285             


Cys Lys Ala Ala Glu Ser Val Tyr Ser Arg Val Ile Gln Val Lys Lys 
    290                 295                 300                 


Met Lys Ala Ile Tyr His Met Leu Asn Met Cys Ser Phe Asp Val Thr 
305                 310                 315                 320 


Asn Lys Cys Leu Ile Ala Glu Val Trp Cys Pro Glu Ala Asp Leu Gln 
                325                 330                 335     


Asp Leu Arg Arg Ala Leu Glu Glu Gly Ser Arg Glu Ser Gly Ala Thr 
            340                 345                 350         


Ile Pro Ser Phe Met Asn Ile Ile Pro Thr Lys Glu Thr Pro Pro Thr 
        355                 360                 365             


Arg Ile Arg Thr Asn Lys Phe Thr Glu Gly Phe Gln Asn Ile Val Asp 
    370                 375                 380                 


Ala Tyr Gly Val Gly Ser Tyr Arg Glu Val Asn Pro Ala Leu Phe Thr 
385                 390                 395                 400 


Ile Ile Thr Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly 
                405                 410                 415     


His Gly Phe Val Met Phe Leu Phe Ala Leu Leu Leu Val Leu Asn Glu 
            420                 425                 430         


Asn His Pro Arg Leu Asn Gln Ser Gln Glu Ile Met Arg Met Phe Phe 
        435                 440                 445             


Asn Gly Arg Tyr Ile Leu Leu Leu Met Gly Leu Phe Ser Val Tyr Thr 
    450                 455                 460                 


Gly Leu Ile Tyr Asn Asp Cys Phe Ser Lys Ser Val Asn Leu Phe Gly 
465                 470                 475                 480 


Ser Gly Trp Asn Val Ser Ala Met Tyr Ser Ser Ser His Pro Pro Ala 
                485                 490                 495     


Glu His Lys Lys Met Val Leu Trp Asn Asp Ser Val Val Arg His Asn 
            500                 505                 510         


Ser Ile Leu Gln Leu Asp Pro Ser Ile Pro Gly Val Phe Arg Gly Pro 
        515                 520                 525             


Tyr Pro Leu Gly Ile Asp Pro Ile Trp Asn Leu Ala Thr Asn Arg Leu 
    530                 535                 540                 


Thr Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly Ile 
545                 550                 555                 560 


Ile His Met Thr Phe Gly Val Ile Leu Gly Ile Phe Asn His Leu His 
                565                 570                 575     


Phe Arg Lys Lys Phe Asn Ile Tyr Leu Val Ser Ile Pro Glu Leu Leu 
            580                 585                 590         


Phe Met Leu Cys Ile Phe Gly Tyr Leu Ile Phe Met Ile Phe Tyr Lys 
        595                 600                 605             


Trp Leu Val Phe Ser Ala Glu Thr Ser Arg Val Ala Pro Ser Ile Leu 
    610                 615                 620                 


Ile Glu Phe Ile Asn Met Phe Leu Phe Pro Ala Ser Lys Thr Ser Gly 
625                 630                 635                 640 


Leu Tyr Thr Gly Gln Glu Tyr Val Gln Arg Val Leu Leu Val Val Thr 
                645                 650                 655     


Ala Leu Ser Val Pro Val Leu Phe Leu Gly Lys Pro Leu Phe Leu Leu 
            660                 665                 670         


Trp Leu His Asn Gly Arg Ser Cys Phe Gly Val Asn Arg Ser Gly Tyr 
        675                 680                 685             


Thr Leu Ile Arg Lys Asp Ser Glu Glu Glu Val Ser Leu Leu Gly Ser 
    690                 695                 700                 


Gln Asp Ile Glu Glu Gly Asn His Gln Val Glu Asp Gly Cys Arg Glu 
705                 710                 715                 720 


Met Ala Cys Glu Glu Phe Asn Phe Gly Glu Ile Leu Met Thr Gln Val 
                725                 730                 735     


Ile His Ser Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Thr Ala Ser 
            740                 745                 750         


Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu Ser Asp 
        755                 760                 765             


Val Leu Trp Ala Met Leu Met Arg Val Gly Leu Arg Val Asp Thr Thr 
    770                 775                 780                 


Tyr Gly Val Leu Leu Leu Leu Pro Val Ile Ala Leu Phe Ala Val Leu 
785                 790                 795                 800 


Thr Ile Phe Ile Leu Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His 
                805                 810                 815     


Ala Ile Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr Val Gly 
            820                 825                 830         


Ala Gly Thr Lys Phe Val Pro Phe Ser Phe Ser Leu Leu Ser Ser Lys 
        835                 840                 845             


Phe Asn Asn Asp Asp Ser Val Ala 
    850                 855     


<210>  3054
<211>  1814
<212>  DNA
<213>  Homosapiens

<400>  3054
atgggccacg ggcccccacc gccgcccgcc gggaggaccg agcctaagag ggcagccgcc     60

tgaaggaacg cgacggcggc gcccgcagta tttttcagtg ctgtacaagc gtcttgaatt    120

actctggtag cttttccaga aagacccatg acttcaccac atttctcgag ttacgatgaa    180

ggtcctctgg atgtcagcat ggcagccaca aacctggaga accagctgca cagcgcacag    240

aagaacctcc tgttccttca gcgggagcat gccagcacgc tcaaggggct gcactccgag    300

atcaggcggc tgcagcagca ctgcacagat ttaacatatg agctgacagt caaaagttcg    360

gaacagacag gagacgggac ttctaaaagc agtgaattaa agaaaagatg tgaagagctg    420

gaagcccaac tgaaagtgaa agagaacgaa aatgctgagt tgttgaaaga actggagcag    480

aaaaacgcga tgatcacagt gctggagaac accatcaagg agcgagagaa gaagtacctg    540

gaggagctga aggccaagag tcacaagctg accctgctgt ctagcgagct ggagcagcgg    600

gccagcacca tcgcctacct gacctcccag ctgcacgccg ccaagaagaa gctcatgagc    660

tccagcggga cctcagatgc cagcccgtca gggagccccg tgctggccag ctacaagcca    720

gcgcccccca aagacaagct acccgaaacg cctcgccgcc gcatgaaaaa gagcctctca    780

gcccccttgc acccggaatt tgaagaggtc tacagattcg gggcagagag caggaaactc    840

cttttgcggg aaccagtgga tgctatgccc gaccccaccc catttctgct ggctagggag    900

tccgccgagg tccacctcat caaagagagg cccctcgtca tcccccccat cgcctccgac    960

cgaagcggcg agcagcacag cccggcccgc gaaaagccgc acaaggccca cgtcggggtg   1020

gcacatcgga tccaccacgc caccccgccg caggcccagc ccgaggtgaa gaccctggcg   1080

gtcgaccagg tgaacggagg caaggtggtg aggaagcact cagggacgga cagaactgtg   1140

tgaagcccgc cgtgccccac cccgcgctgt ccatgcactg tgagcaccac tgggaaatct   1200

cagccacacc ttttctgttt aatcccatgc atgccaaaca cttttcacac ctaccgaccc   1260

attctccttc tgcttctctt gccctcttct tcacaccaaa atatgatcgt gtccctgccg   1320

cagaatatgt atttcctaat tgctgtggcc aagcgcctgt gtgccgaatc gcttgcttct   1380

gatcccgctc cgtgtaacct aagtgcgctg caggcaaagc ccaggccacg gctgcgtcac   1440

tactgatgtt cacgatgcca cacagtcaca cacctaattc attctcaagt cggagcaaca   1500

cataccaacc ttgaccttat cctcaagctc cagggcagcc tggccgagca gcccctgctc   1560

cctcctggag acccttgtca cctcccgagc tcctcctgga gacccctgtc acctcctgac   1620

caacctttcc cagggcggca ccgatcaccg agcagccgtg cgtgtatctc aaggaactaa   1680

ataagatgac gctactcctc atagcaccac aacctgaatg tgtgttcata tttttttgtt   1740

agttttatcc aaaatgttta agatcccaac aaactttatt ttctaaacct gccaaaaaaa   1800

aaaaaaaaaa aaaa                                                     1814


<210>  3055
<211>  331
<212>  PRT
<213>  Homosapiens

<400>  3055

Met Thr Ser Pro His Phe Ser Ser Tyr Asp Glu Gly Pro Leu Asp Val 
1               5                   10                  15      


Ser Met Ala Ala Thr Asn Leu Glu Asn Gln Leu His Ser Ala Gln Lys 
            20                  25                  30          


Asn Leu Leu Phe Leu Gln Arg Glu His Ala Ser Thr Leu Lys Gly Leu 
        35                  40                  45              


His Ser Glu Ile Arg Arg Leu Gln Gln His Cys Thr Asp Leu Thr Tyr 
    50                  55                  60                  


Glu Leu Thr Val Lys Ser Ser Glu Gln Thr Gly Asp Gly Thr Ser Lys 
65                  70                  75                  80  


Ser Ser Glu Leu Lys Lys Arg Cys Glu Glu Leu Glu Ala Gln Leu Lys 
                85                  90                  95      


Val Lys Glu Asn Glu Asn Ala Glu Leu Leu Lys Glu Leu Glu Gln Lys 
            100                 105                 110         


Asn Ala Met Ile Thr Val Leu Glu Asn Thr Ile Lys Glu Arg Glu Lys 
        115                 120                 125             


Lys Tyr Leu Glu Glu Leu Lys Ala Lys Ser His Lys Leu Thr Leu Leu 
    130                 135                 140                 


Ser Ser Glu Leu Glu Gln Arg Ala Ser Thr Ile Ala Tyr Leu Thr Ser 
145                 150                 155                 160 


Gln Leu His Ala Ala Lys Lys Lys Leu Met Ser Ser Ser Gly Thr Ser 
                165                 170                 175     


Asp Ala Ser Pro Ser Gly Ser Pro Val Leu Ala Ser Tyr Lys Pro Ala 
            180                 185                 190         


Pro Pro Lys Asp Lys Leu Pro Glu Thr Pro Arg Arg Arg Met Lys Lys 
        195                 200                 205             


Ser Leu Ser Ala Pro Leu His Pro Glu Phe Glu Glu Val Tyr Arg Phe 
    210                 215                 220                 


Gly Ala Glu Ser Arg Lys Leu Leu Leu Arg Glu Pro Val Asp Ala Met 
225                 230                 235                 240 


Pro Asp Pro Thr Pro Phe Leu Leu Ala Arg Glu Ser Ala Glu Val His 
                245                 250                 255     


Leu Ile Lys Glu Arg Pro Leu Val Ile Pro Pro Ile Ala Ser Asp Arg 
            260                 265                 270         


Ser Gly Glu Gln His Ser Pro Ala Arg Glu Lys Pro His Lys Ala His 
        275                 280                 285             


Val Gly Val Ala His Arg Ile His His Ala Thr Pro Pro Gln Ala Gln 
    290                 295                 300                 


Pro Glu Val Lys Thr Leu Ala Val Asp Gln Val Asn Gly Gly Lys Val 
305                 310                 315                 320 


Val Arg Lys His Ser Gly Thr Asp Arg Thr Val 
                325                 330     


<210>  3056
<211>  5125
<212>  DNA
<213>  Homosapiens

<400>  3056
ggaggcgggc ggtgggggcg cgggccgggt ggccgcgcat gcgtgcggcc cccgctcccc     60

cggggcttcc ccggcctcgt gcgtgcgcac gcgcgctgtc ccccggaggc gtctgggtgt    120

gcggagcgcg cgcgcgcgcg gctcggaggc gcacctgtga ggtgtccctg aggagaggga    180

ggtgggtgcg cggcgcccgc ggcctggggc gctgactccc ctcacttgga gtgagttctc    240

ggcggccggg ctgcagtctt tctttctttc ccggagggag gcgggggccg ggggccaggg    300

agcgggctgg gggtgggaag gaggtggagt ggcttaaaga aaagaaaaac aacccatccc    360

ggaggatggg cctcgggatg gcggggaagg tcagagcggc tccgcgcagc ctggcgggtc    420

ccgggctgag aagccgcccc tcgggcctcg ggcggtcggc cgcgggcccg cagtgcgggg    480

gagcggggcc ggggggcgca gatggcggcc ggtgcgagcg agggctgggc agcgggcagg    540

gcgaggccgg gcgaggcccc tcgggagccg gactcccgag ccaggctcca ttgttgttgg    600

agccgaggga agggggagcg ctgccgccct cgtcgcccgt ggagccgcgt cttggagccc    660

ttccaggcgg gtcccgggag aggcggtcat ggccgcgcca ggggaccggg gagccgggcg    720

gctgcggagg agccggctgc atggggtgct gtgtgttttt cagggcgccc tgcgtccggc    780

agaggaggcg agcatcccgc tcaggtgatg aggaacccct cgcgcaccca gcgcagaagg    840

ctgctgccgc cggacgcctc cattgtttga ccacaacaag ggccggattc tcacccagca    900

ggatcctaag gcctttgtag tccttcagcc actgtgggcc ctgcctctgc ctgttcttct    960

ggaatgtctt gggggttttg atcctgtcac tgtgagtctt gctctgtcgc ccaggctgga   1020

gtgcagtggc acgatctcag ctcattgcaa cctctgtctc ccaggttcaa gcgattctcc   1080

tgcctcagcc tctggagtag ctgggattac agatgggacc acctagttgc aggaaaacaa   1140

gctcagggct cccactgatt ctacattatg acctgcaaat ccaagagaca catctttgga   1200

agataagaga gcttcttcaa gaccaaaaaa ggagacggca tgatacccat gtagggaatt   1260

ccccaaagca gggcttgcca tacctggacc ccgaggagcc tgcttgctgg aaaggctttc   1320

ctgtctgatg tgcaggaggc agaatgccaa actgactctt caaggggcaa ctgcaggggc   1380

tcgagaccag ccagcagtat ctcatccttc gatacagggg atatactgta cagtcctttt   1440

tctagaagtg agacatacaa gattactcta caagaggaag attccagggg ctcaaaaacg   1500

caaaggtttg cactttgaga gccccttgga atgttgacaa ctcaggatct aaaacaaagt   1560

tctgtgttaa tgagttacag aattcacgtg gaagtcaatg tcactttata atcgataata   1620

atactgagtg aggaacacta tgcaggaaga aaccttccgt agaaagacag gcagggaaaa   1680

gcttaggctg accttaaact tacctaatag agcaagcctg agatagactg ccaaaatggc   1740

caaataagag actctatgaa ataacagtct tgtaactgta gtaatcataa ggaaattttc   1800

tccttgaaat cacgatacca aataggaaaa atgatctaca agtgccccat gtgtagggaa   1860

tttttctctg agagagcaga tctttttatg catcagaaaa ttcacacagc tgagaagccc   1920

cataaatgtg acaagtgtga taagggtttc tttcatatat cagaacttca tattcattgg   1980

agagaccata caggagagaa ggtctataaa tgtgatgatt gtggtaagga ttttagcact   2040

acaacaaaac ttaatagaca taagaaaatc cacacagtgg agaagcccta taaatgttac   2100

gagtgtggca aagccttcaa ttggagctcc catcttcaaa ttcatatgag agttcataca   2160

ggtgagaaac cgtatgtctg tagtgagtgt ggaaggggct ttagtaatag ttcaaacctt   2220

tgcatgcatc agagagtcca caccggagag aagcccttta aatgtgaaga gtgtgggaag   2280

gccttcaggc acacctccag cctctgcatg catcaaagag tccacacagg agagaaaccc   2340

tataaatgtt atgagtgtgg gaaggcgttc agtcagagtt cgagcctctg catccaccag   2400

agagtccaca ctggagagaa accctataga tgttgtggat gtgggaaggc cttcagtcag   2460

agttcgagcc tgtgcatcca ccagagagtc cacacaggag agaaaccttt caaatgtgat   2520

gagtgcggaa aggccttcag tcagagtacg agcctctgca tccaccagag agtccacaca   2580

aaggagagaa accatctcaa aatatcagtt atataaaacg ttttgctaag agtttaaaat   2640

cttaaaaccc ataagtgcca ctaggaagga aaccctgtat atacctacat tgactcaaga   2700

aatatttacg caatccctag cagaacattg tttctgagga ggcatatgtg agattgattt   2760

gttggttcat gccaagtgtg ttccacaggt tgactttgaa tgtggacctc tgagcatcca   2820

cgcaggatgg ctctcaggtc ccagtcacag acgtcgcttc ctgggattcc agcacgatgc   2880

ctccatagtt gaaagactac acaaaaagcc acaatcattg cccggcctcc tgagtcacct   2940

tctatctata ctttgcttaa aagctatccc agatactccc ccttgaggag ctcatgccct   3000

tccttcctct ttattcgagc atactggcaa tgcattggaa aacagacagc tcccactaag   3060

atcacgttct ggtatttctg aggttaacac ttgatttagc ccctacatat ctttccatat   3120

atcctattat ttctgaatat atgtcctcaa aatccccata aatatccatc ccttcctaga   3180

tggcattaac tttcatttta gattttaggt gactcataat tcccattcac ttagcctatc   3240

agaaaagtca ttggcagaca tatatgtcct tgaacctttt ttatttgtgt ggattctgct   3300

catcactgtc tctgttagac ttattttgta gtggctgcat cacatatttt tcacttgaat   3360

ttttttggaa atagctgaat gtaaatagca gggaggaaga agcaagcaaa gtgagagctt   3420

ttcttcatcc agaattgccc tctgggctcc tttggtaaca gatggagctc cttcctagct   3480

agggagacct tatgagaagt ggatggtagg aggagtcact aatgtttcaa tctctatttc   3540

tgtaatcttg ggcaataatg cataggagtt cttgataccc cttcattgat tactgtgtat   3600

cagttctttg ttaggcatga acgtctttat taatccatca ttcttttctt cattcaacaa   3660

atatgtattg aacacctcct atatgccagg cactgtgcta ggtgctggga ataccactga   3720

tgagacagac aaggtcccta ctcttgtgga gtttacttct ggtggaggag acagatgata   3780

agtaaacaaa taaataatgt agtttgagat agtgattaag tgctatgaag aaaataaact   3840

agggtgatga ttttagtggt ggggtggggt gggggtgggg tgacattagc tagtggtcag   3900

ggaggccttt ccgcggtggg atgttgagct gaggccggag gagaagtagc agtcgctggc   3960

agagcacaca ggctgctctg ggggatgagc tggtgcgttt aaggaacagg ccagcactgg   4020

cattcgcaag cagtggggaa ggggagagat gccgaggtgg tcagtatcct gactttcaga   4080

ggcctttttt tgtttgtttt aatttttgct agattgatat taaaaactca tgtggaggaa   4140

ctcaaggaat gtttagaaga ccaaaagtcc ccaatgacag gaacaaaagc aaccaatttt   4200

taactttctc ttctcattcc tgttttcatt gatttcccac atgtagtcct tttgctcagg   4260

aagtctttgg ggaaattaag gatctttgaa gctctgaaat aggtgatcag gttagtggtg   4320

tctgtcagct gtctaagagg ttggaaaatg aactactcaa gatagtcacg aaaatactga   4380

aagtttgatt tttctttcca tatttgaatt aattttttct gtttgactgg aaggggtttt   4440

tgtataacta aaacctcagc gcataaagga gatttaaaag gagcacatga tttagtgggt   4500

gggccatgaa actagagatg ggatttgggg gtgaatttgt caatatctgg attttaatcc   4560

agacatctct gctaacaagc ctttggtaag tcacttcaga tacttttcct cctttttaca   4620

aagagagggc tggcttagtt atttgccaaa gccccttcca ggcctgaatt ccacaagtac   4680

gatttactgt agtgtcttat cactctttca tgtcacaata gcgtggagca ttagagaaaa   4740

gcctagactt ttagttgata gccagttgaa atatcattga tagaatttta gttttaggaa   4800

aaattggttt gatttctagc tttattacta ttaggtatgt gagcttgggc aaatcgctta   4860

atctttgagt ctagttttct ctcaaaatga gaacattagg ctaaatgatt tccgagtttc   4920

cagctagtcc tagagttcta tatttctaca tagttgaatt attttatcat gctgttgctg   4980

gggaatatga ctaacccttt tgaagctact aattttatgt cgagctttaa agtccataat   5040

tgttatcttc agaaaatatt atttgaccta cagtatgtcc aaatcaattt aataaaatcg   5100

ctttataaaa aaaaaaaaaa aaaaa                                         5125


<210>  3057
<211>  261
<212>  PRT
<213>  Homosapiens

<400>  3057

Met Ile Tyr Lys Cys Pro Met Cys Arg Glu Phe Phe Ser Glu Arg Ala 
1               5                   10                  15      


Asp Leu Phe Met His Gln Lys Ile His Thr Ala Glu Lys Pro His Lys 
            20                  25                  30          


Cys Asp Lys Cys Asp Lys Gly Phe Phe His Ile Ser Glu Leu His Ile 
        35                  40                  45              


His Trp Arg Asp His Thr Gly Glu Lys Val Tyr Lys Cys Asp Asp Cys 
    50                  55                  60                  


Gly Lys Asp Phe Ser Thr Thr Thr Lys Leu Asn Arg His Lys Lys Ile 
65                  70                  75                  80  


His Thr Val Glu Lys Pro Tyr Lys Cys Tyr Glu Cys Gly Lys Ala Phe 
                85                  90                  95      


Asn Trp Ser Ser His Leu Gln Ile His Met Arg Val His Thr Gly Glu 
            100                 105                 110         


Lys Pro Tyr Val Cys Ser Glu Cys Gly Arg Gly Phe Ser Asn Ser Ser 
        115                 120                 125             


Asn Leu Cys Met His Gln Arg Val His Thr Gly Glu Lys Pro Phe Lys 
    130                 135                 140                 


Cys Glu Glu Cys Gly Lys Ala Phe Arg His Thr Ser Ser Leu Cys Met 
145                 150                 155                 160 


His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys Tyr Glu Cys 
                165                 170                 175     


Gly Lys Ala Phe Ser Gln Ser Ser Ser Leu Cys Ile His Gln Arg Val 
            180                 185                 190         


His Thr Gly Glu Lys Pro Tyr Arg Cys Cys Gly Cys Gly Lys Ala Phe 
        195                 200                 205             


Ser Gln Ser Ser Ser Leu Cys Ile His Gln Arg Val His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Phe Lys Cys Asp Glu Cys Gly Lys Ala Phe Ser Gln Ser Thr 
225                 230                 235                 240 


Ser Leu Cys Ile His Gln Arg Val His Thr Lys Glu Arg Asn His Leu 
                245                 250                 255     


Lys Ile Ser Val Ile 
            260     


<210>  3058
<211>  2566
<212>  DNA
<213>  Homosapiens

<400>  3058
cgtcgccgtc cccgtctcct gccaggcgcg gagccctgcg agccgcgggt gggccccagg     60

cgcgcagaca tgggctgctc cgccaaagcg cgctgggctg ccggggcgct gggcgtcgcg    120

gggctactgt gcgctgtgct gggcgctgtc atgatcgtga tggtgccgtc gctcatcaag    180

cagcaggtcc ttaagaacgt gcgcatcgac cccagtagcc tgtccttcaa catgtggaag    240

gagatcccta tccccttcta tctctccgtc tacttctttg acgtcatgaa ccccagcgag    300

atcctgaagg gcgagaagcc gcaggtgcgg gagcgcgggc cctacgtgta cagggagtcc    360

aggcacaaaa gcaacatcac cttcaacaac aacgacaccg tgtccttcct cgagtaccgc    420

accttccagt tccagccctc caagtcccac ggctcggaga gcgactacat cgtcatgccc    480

aacatcctgg tcttgggtgc ggcggtgatg atggagaata agcccatgac cctgaagctc    540

atcatgacct tggcattcac caccctcggc gaacgtgcct tcatgaaccg cactgtgggt    600

gagatcatgt ggggctacaa ggaccccctt gtgaatctca tcaacaagta ctttccaggc    660

atgttcccct tcaaggacaa gttcggatta tttgctgagc tcaacaactc cgactctggg    720

ctcttcacgg tgttcacggg ggtccagaac atcagcagga tccacctcgt ggacaagtgg    780

aacgggctga gcaaggttga cttctggcat tccgatcagt gcaacatgat caatggaact    840

tctgggcaaa tgtggccgcc cttcatgact cctgagtcct cgctggagtt ctacagcccg    900

gaggcctgcc gatccatgaa gctaatgtac aaggagtcag gggtgtttga aggcatcccc    960

acctatcgct tcgtggctcc caaaaccctg tttgccaacg ggtccatcta cccacccaac   1020

gaaggcttct gcccgtgcct ggagtctgga attcagaacg tcagcacctg caggttcagt   1080

gcccccttgt ttctctccca tcctcacttc ctcaacgccg acccggttct ggcagaagcg   1140

gtgactggcc tgcaccctaa ccaggaggca cactccttgt tcctggacat ccacccggtc   1200

acgggaatcc ccatgaactg ctctgtgaaa ctgcagctga gcctctacat gaaatctgtc   1260

gcaggcattg gacaaactgg gaagattgag cctgtggtcc tgccgctgct ctggtttgca   1320

gagagcgggg ccatggaggg ggagactctt cacacattct acactcagct ggtgttgatg   1380

cccaaggtga tgcactatgc ccagtacgtc ctcctggcgc tgggctgcgt cctgctgctg   1440

gtccctgtca tctgccaaat ccggagccaa gagaaatgct atttattttg gagtagtagt   1500

aaaaagggct caaaggataa ggaggccatt caggcctatt ctgaatccct gatgacatca   1560

gctcccaagg gctctgtgct gcaggaagca aaactgtagg gtcctgagga caccgtgagc   1620

cagccaggcc tggccgctgg gcctgaccgg ccccccagcc cctacacccc gcttctcccg   1680

gactctccca gcagacagcc ccccagcccc acagcctgag cctcccagct gccatgtgcc   1740

tgttgcacac ctgcacacac gccctggcac acatacacac atgcgtgcag gcttgtgcag   1800

acactcaggg atggagctgc tgctgaaggg acttgtaggg agaggctcgt caacaagcac   1860

tgttctggaa ccttctctcc acgtggccca caggctgacc acaggggctg tgggtcctgc   1920

gtccccttcc tcgggtgagc ctggcctgtc ccgttcagcc gttgggccag gcttcctccc   1980

ctccaaggtg aaacactgca gtcccggtgt ggtggctccc catgcaggac gggccaggct   2040

gggagtgccg ccttcctgtg ccaaattcag tggggactca gtgcccaggc cctggcacga   2100

gctttggcct tggtctacct gccaggccag gcaaagcgcc tttacacagg cctcggaaaa   2160

caatggagtg agcacaagat gccctgtgca gctgcccgag ggtctccgcc caccccggcc   2220

ggactttgat ccccccgaag tcttcacagg cactgcatcg ggttgtctgg cgcccttttc   2280

ctccagccta aactgacatc atcctatgga ctgagccggc cactctctgg ccgaagtggc   2340

gcaggctgtg cccccgagct gcccccaccc cctcacaggg tccctcagat tataggtgcc   2400

caggctgagg tgaagaggcc tgggggccct gccttccggg cgctcctgga ccctggggca   2460

aacctgtgac ccttttctac tggaatagaa atgagtttta tcatctttga aaaataattc   2520

actcttgaag taataaacgt ttaaaaaaat ggaaaaaaaa aaaaaa                  2566


<210>  3059
<211>  509
<212>  PRT
<213>  Homosapiens

<400>  3059

Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala Leu Gly Val 
1               5                   10                  15      


Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile Val Met Val 
            20                  25                  30          


Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
        35                  40                  45              


Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr 
    50                  55                  60                  


Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys 
65                  70                  75                  80  


Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                85                  90                  95      


Ser Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser 
            100                 105                 110         


Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly 
        115                 120                 125             


Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala 
    130                 135                 140                 


Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr 
145                 150                 155                 160 


Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val 
                165                 170                 175     


Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn 
            180                 185                 190         


Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe 
        195                 200                 205             


Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly 
    210                 215                 220                 


Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
225                 230                 235                 240 


Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly 
                245                 250                 255     


Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu 
            260                 265                 270         


Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys 
        275                 280                 285             


Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro 
    290                 295                 300                 


Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe 
305                 310                 315                 320 


Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                325                 330                 335     


Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro 
            340                 345                 350         


Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His 
        355                 360                 365             


Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
    370                 375                 380                 


Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                405                 410                 415     


Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr 
            420                 425                 430         


Gln Leu Val Leu Met Pro Lys Val Met His Tyr Ala Gln Tyr Val Leu 
        435                 440                 445             


Leu Ala Leu Gly Cys Val Leu Leu Leu Val Pro Val Ile Cys Gln Ile 
    450                 455                 460                 


Arg Ser Gln Glu Lys Cys Tyr Leu Phe Trp Ser Ser Ser Lys Lys Gly 
465                 470                 475                 480 


Ser Lys Asp Lys Glu Ala Ile Gln Ala Tyr Ser Glu Ser Leu Met Thr 
                485                 490                 495     


Ser Ala Pro Lys Gly Ser Val Leu Gln Glu Ala Lys Leu 
            500                 505                 


<210>  3060
<211>  2443
<212>  DNA
<213>  Homosapiens

<400>  3060
ataccagggg tgggcactgt caagagaccc agctttgact tcaaatgcca cccagaggga     60

caactgctca ctttcagagc aggagcagga ggccagagga gagtgggtcc ctatgatcca    120

gacctcaaga gagggttcct ggacctccca cagaaaggga ttcaagacca gctgaaactg    180

attagagcca agatagccaa ccaaatgact tcaggaagac ctcaggcttc attatcatct    240

catttccatg ctaaaaaaac ccagctccct agaacaatgg gaaatattgg gcacttcatc    300

aggcgagttc aggtgcattt ctagagattg tccaggtgct ggtaacaata atagagaacc    360

atccatatcc acaagaggca gaacctcttc cagcaaaatg gtgctgcctc acccaaaggt    420

ggccgaggag gccgtcggag gaccacaaag ctgcaagtgg ctttcctgcg gcctgcaggg    480

aacaggtgga ggacacttgg aagggcaccc accccgggtc tcacaggagt ctgcacccgc    540

aggtcacact ggcattagcc cctcatcctc tggagttcat ctcatccagg cgaagacagc    600

tggctggcct cagagggtga gacgcaactc gagggtaaaa acatttttac agggcatgga    660

cacaaaagtg gcctttacct ctggataagc ttttaaaact tcccatttac atgtaaaggt    720

gtactttcta tgtgccacca agaaacctaa agtgagtaaa aggtgtttca ctttaatcaa    780

gttccccaat gagggggcac agctctgaaa agcactgtca caacaggaga ttcgagggtg    840

catgcaaagc aatgtttcta gaaaatgcca aaggaaacag acacaactcc agtgtggact    900

cccgcttccc tgcactgctg ctccatcctc agggcggagg ccacatcgtc cagctagctg    960

tgagaacctc atcatgctcc ttgattgtgt gcagcaggtg tctgctgaag tcctccacac   1020

tctgcctgtc tcatccgctg agcagtgcct cctcccgatt cagcacgtcc ctggtgccga   1080

ctttctgcac gtgttcactt tgaggctgca ttgtgggcct gcaagaaatg caaagctggt   1140

tgaggcttta ttcaattcaa attcaagctg ttaaatcgag gctctcagac tcctgctgcc   1200

tggccagtgg agaaattaac tttcacatat ggctttggga tttctctctg tcatcctggt   1260

cgacgtgttc tctcattttt ctgaagtctg ggacctcaac acagacatct gggtgaaggc   1320

cttgacagca gcgctggtgc aaaatgaatt gtcacatcac acccaacgtt ctcaaccttt   1380

agaatctgaa agtaagaaaa acacctcaaa caaaacatta aagattgaat aattgaaggc   1440

actatgcttg gtgctgaaga aggtctaagg aggtctacac cacagaggct gcacccactc   1500

ctcagccttg ctgagccaca ccattctcat ctctacagca tccacctctc ttggctcttg   1560

taaggattga gacatgccac caggcttact attgattctg agtaatcagc acagatttct   1620

aaaagaaact ttatgggatg ctgagacatg aataaaaaca actttattcc tttggaaagg   1680

acaacccaca tgctaagaag atgacactac acgttgttat agcccgaaag gccctctttc   1740

cacaggggag cagtgaaaag tagaggttgc ccatgtggat tcccaagtca gatagatgtg   1800

gattcagatc ccagctctgc tgcttgctac ccaagagacc atggactgtg gactctttag   1860

gtctcagggt ttttgtttgt tgtctgtttt tcacttccaa aaccagaaaa tgagaagata   1920

ttttccataa gatggcggtg gagaagagaa cttgatggac cttgcttgga caaaatgcct   1980

tcaccgctaa ctcagtcagc tatggcgatg ggtcaaggac ctggtggttt tacagagaag   2040

acccttggtc aaatctttgt gaatgaagca accattctga tgttcaataa caggaatgca   2100

ccagtttata ccaaactatc tgtactattg agaacagcaa aaatatctga ccaaaaacac   2160

caaagagtga cattttaaaa gacatcaaag aactctcaag gcttccagag ttggaaagat   2220

caagaaagag agaatgcaac ttcattaagt gactcaactc caaataggag catttcaaga   2280

gtatgtattt caacaaagaa gtattagaag atgacagtgt ccttgcagta tcttttaggg   2340

gctatcagaa catgatttct gctatattct atcatcggag ccttaataat gttaactata   2400

attcaaggga agatcaaata aacttcacct ttcaaggaaa gga                     2443


<210>  3061
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  3061

Met Leu Lys Lys Pro Ser Ser Leu Glu Gln Trp Glu Ile Leu Gly Thr 
1               5                   10                  15      


Ser Ser Gly Glu Phe Arg Cys Ile Ser Arg Asp Cys Pro Gly Ala Gly 
            20                  25                  30          


Asn Asn Asn Arg Glu Pro Ser Ile Ser Thr Arg Gly Arg Thr Ser Ser 
        35                  40                  45              


Ser Lys Met Val Leu Pro His Pro Lys Val Ala Glu Glu Ala Val Gly 
    50                  55                  60                  


Gly Pro Gln Ser Cys Lys Trp Leu Ser Cys Gly Leu Gln Gly Thr Gly 
65                  70                  75                  80  


Gly Gly His Leu Glu Gly His Pro Pro Arg Val Ser Gln Glu Ser Ala 
                85                  90                  95      


Pro Ala Gly His Thr Gly Ile Ser Pro Ser Ser Ser Gly Val His Leu 
            100                 105                 110         


Ile Gln Ala Lys Thr Ala Gly Trp Pro Gln Arg Val Arg Arg Asn Ser 
        115                 120                 125             


Arg Val Lys Thr Phe Leu Gln Gly Met Asp Thr Lys Val Ala Phe Thr 
    130                 135                 140                 


Ser Gly 
145     


<210>  3062
<211>  2807
<212>  DNA
<213>  Homosapiens

<400>  3062
caggttgggt tctgggacag gtgacccggc ggcggggcga ggcagctggc ggcgtcgcat     60

ggagggctct gggggcggtg cgggcgagcg ggcgccgctg ctgggcgcgc ggcgggcggc    120

ggcggccgcg gcggcggctg gggcgttcgc gggccggcgc gcggcgtgcg gggccgtgct    180

gctgacggag ctgctggagc gcgccgcttt ctacggcatc acgtccaacc tggtgctatt    240

cctgaacggg gcgccgttct gctgggaggg cgcgcaggcc agcgaggcgc tgctgctctt    300

catgggcctc acctacctgg gctcgccgtt cggaggctgg ctggccgacg cgcggctggg    360

ccgggcgcgc gccatcctgc tgagcctggc gctctacctg ctgggcatgc tggccttccc    420

gctgctggcc gcgcccgcca cgcgagccgc gctctgcggt tccgcgcgcc tgctcaactg    480

cacggcgcct ggtcccgacg ccgccgcccg ctgctgctca ccggccacct tcgcggggct    540

ggtgctggtg ggcctgggcg tggccaccgt caaggccaac atcacgccct tcggcgccga    600

ccaggttaaa gatcgaggtc cggaagccac taggagattt tttaattggt tttattggag    660

cattaacctg ggagcgatcc tgtcgttagg tggcattgcc tatattcagc agaacgtcag    720

ctttgtcact ggttatgcga tccccactgt ctgcgtcggc cttgcttttg tggtcttcct    780

ctgtggccag agcgttttca tcaccaagcc tcctgatggc agtgccttca ccgacatgtt    840

caagatactg acgtattcct gctgttccca gaagcgaagt ggagagcgcc agagtaatgg    900

tgaaggcatt ggagtctttc agcaatcttc taaacaaagt ctgtttgatt catgtaagat    960

gtctcatggt gggccattta cagaagagaa agtggaagat gtgaaagctc tggtcaagat   1020

tgtccctgtt ttcttggctt tgatacctta ctggacagtg tatttccaaa tgcagacaac   1080

atatgtttta cagagtcttc atttgaggat tccagaaatt tcaaatatta caaccactcc   1140

tcacacgctc cctgcagcct ggctgaccat gtttgatgct gtgctcatcc tcctgctcat   1200

ccctctgaag gacaaactgg tcgatcccat tttgagaaga catggcctgc tcccatcctc   1260

cctgaagagg atcgccgtgg gcatgttctt tgtcatgtgc tcggcctttg ctgcaggaat   1320

tttggagagt aaaaggctga accttgttaa agagaaaacc attaatcaga ccatcggcaa   1380

cgtcgtctac catgctgccg atctgtcgct gtggtggcag gtgccgcagt acttgctgat   1440

tgggatcagc gagatctttg caagtatcgc aggcctggaa tttgcatact cagctgcccc   1500

caagtccatg cagagtgcca taatgggctt gttctttttc ttctctggcg tcgggtcgtt   1560

cgtgggttct ggactgctgg cactggtgtc tatcaaagcc atcggatgga tgagcagtca   1620

cacagacttt ggtaatatta acggctgcta tttgaactat tacttttttc ttctggctgc   1680

tattcaagga gctaccctcc tgcttttcct cattatttct gtgaaatatg accatcatcg   1740

agaccatcag cgatcaagag ccaatggcgt gcccaccagc aggagggcct gaccttcctg   1800

aggccatgtg cggtttctga ggctgacatg tcagtaactg actggggtgc actgagaaca   1860

ggcaagactt taaattccca taaaatgtct gacttcactg aaacttgcat gttgcctgga   1920

ttgatttctt ctttccctct atccaaagga gcttggtaag tgccttactg cagcgtgtct   1980

cctggcacgc tgggccctcc gggaggagag ctgcagattt cgagtatgtc gcttgtcatt   2040

caaggtctct gtgaatcctc tagctgggtt ccctttttta cagaaactca caaatggaga   2100

ttgcaaagtc ttggggaact ccacgtgtta gttggcatcc cagtttctta aacaaatagt   2160

atcacctgct tcccatagcc atatctcact gtaaaaaaaa aaaattaata aactgttact   2220

tatatttaag aaagtgagga tttttttttt ttaaagataa aagcatggtc agatgctgca   2280

aggattttac ataaatgcca tatttatggt ttccttcctg agaacagtct tgctcttgcc   2340

atgttctttg atttaggctg gtagtaaaca catttcatct gctgcttcaa aaagtactta   2400

ctttttaaac catcaacatt acttttcttt cttaaggcaa ggcatgcata agagtcattt   2460

gagaccatgt gtcccatctc aagccacaga gcaactcaca gggtacttca caccttacct   2520

agtcagagtg cttatatata gctttatttt ggtacgattg agactaaaga ctgatcatgg   2580

ttgtatgtaa ggaaaacatt cttttgaaca gaaatagtgt aattaaaaat aattgaaagt   2640

gttaaatgtg aacttgagct gtttgaccag ccacattttt gtattgttac tgtacgtgta   2700

tctggggctt ctccgtttgt taatactttt tctgtatttg ttgctgtatt tttggcataa   2760

ctttattata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 2807


<210>  3063
<211>  577
<212>  PRT
<213>  Homosapiens

<400>  3063

Met Glu Gly Ser Gly Gly Gly Ala Gly Glu Arg Ala Pro Leu Leu Gly 
1               5                   10                  15      


Ala Arg Arg Ala Ala Ala Ala Ala Ala Ala Ala Gly Ala Phe Ala Gly 
            20                  25                  30          


Arg Arg Ala Ala Cys Gly Ala Val Leu Leu Thr Glu Leu Leu Glu Arg 
        35                  40                  45              


Ala Ala Phe Tyr Gly Ile Thr Ser Asn Leu Val Leu Phe Leu Asn Gly 
    50                  55                  60                  


Ala Pro Phe Cys Trp Glu Gly Ala Gln Ala Ser Glu Ala Leu Leu Leu 
65                  70                  75                  80  


Phe Met Gly Leu Thr Tyr Leu Gly Ser Pro Phe Gly Gly Trp Leu Ala 
                85                  90                  95      


Asp Ala Arg Leu Gly Arg Ala Arg Ala Ile Leu Leu Ser Leu Ala Leu 
            100                 105                 110         


Tyr Leu Leu Gly Met Leu Ala Phe Pro Leu Leu Ala Ala Pro Ala Thr 
        115                 120                 125             


Arg Ala Ala Leu Cys Gly Ser Ala Arg Leu Leu Asn Cys Thr Ala Pro 
    130                 135                 140                 


Gly Pro Asp Ala Ala Ala Arg Cys Cys Ser Pro Ala Thr Phe Ala Gly 
145                 150                 155                 160 


Leu Val Leu Val Gly Leu Gly Val Ala Thr Val Lys Ala Asn Ile Thr 
                165                 170                 175     


Pro Phe Gly Ala Asp Gln Val Lys Asp Arg Gly Pro Glu Ala Thr Arg 
            180                 185                 190         


Arg Phe Phe Asn Trp Phe Tyr Trp Ser Ile Asn Leu Gly Ala Ile Leu 
        195                 200                 205             


Ser Leu Gly Gly Ile Ala Tyr Ile Gln Gln Asn Val Ser Phe Val Thr 
    210                 215                 220                 


Gly Tyr Ala Ile Pro Thr Val Cys Val Gly Leu Ala Phe Val Val Phe 
225                 230                 235                 240 


Leu Cys Gly Gln Ser Val Phe Ile Thr Lys Pro Pro Asp Gly Ser Ala 
                245                 250                 255     


Phe Thr Asp Met Phe Lys Ile Leu Thr Tyr Ser Cys Cys Ser Gln Lys 
            260                 265                 270         


Arg Ser Gly Glu Arg Gln Ser Asn Gly Glu Gly Ile Gly Val Phe Gln 
        275                 280                 285             


Gln Ser Ser Lys Gln Ser Leu Phe Asp Ser Cys Lys Met Ser His Gly 
    290                 295                 300                 


Gly Pro Phe Thr Glu Glu Lys Val Glu Asp Val Lys Ala Leu Val Lys 
305                 310                 315                 320 


Ile Val Pro Val Phe Leu Ala Leu Ile Pro Tyr Trp Thr Val Tyr Phe 
                325                 330                 335     


Gln Met Gln Thr Thr Tyr Val Leu Gln Ser Leu His Leu Arg Ile Pro 
            340                 345                 350         


Glu Ile Ser Asn Ile Thr Thr Thr Pro His Thr Leu Pro Ala Ala Trp 
        355                 360                 365             


Leu Thr Met Phe Asp Ala Val Leu Ile Leu Leu Leu Ile Pro Leu Lys 
    370                 375                 380                 


Asp Lys Leu Val Asp Pro Ile Leu Arg Arg His Gly Leu Leu Pro Ser 
385                 390                 395                 400 


Ser Leu Lys Arg Ile Ala Val Gly Met Phe Phe Val Met Cys Ser Ala 
                405                 410                 415     


Phe Ala Ala Gly Ile Leu Glu Ser Lys Arg Leu Asn Leu Val Lys Glu 
            420                 425                 430         


Lys Thr Ile Asn Gln Thr Ile Gly Asn Val Val Tyr His Ala Ala Asp 
        435                 440                 445             


Leu Ser Leu Trp Trp Gln Val Pro Gln Tyr Leu Leu Ile Gly Ile Ser 
    450                 455                 460                 


Glu Ile Phe Ala Ser Ile Ala Gly Leu Glu Phe Ala Tyr Ser Ala Ala 
465                 470                 475                 480 


Pro Lys Ser Met Gln Ser Ala Ile Met Gly Leu Phe Phe Phe Phe Ser 
                485                 490                 495     


Gly Val Gly Ser Phe Val Gly Ser Gly Leu Leu Ala Leu Val Ser Ile 
            500                 505                 510         


Lys Ala Ile Gly Trp Met Ser Ser His Thr Asp Phe Gly Asn Ile Asn 
        515                 520                 525             


Gly Cys Tyr Leu Asn Tyr Tyr Phe Phe Leu Leu Ala Ala Ile Gln Gly 
    530                 535                 540                 


Ala Thr Leu Leu Leu Phe Leu Ile Ile Ser Val Lys Tyr Asp His His 
545                 550                 555                 560 


Arg Asp His Gln Arg Ser Arg Ala Asn Gly Val Pro Thr Ser Arg Arg 
                565                 570                 575     


Ala 
    


<210>  3064
<211>  2721
<212>  DNA
<213>  Homosapiens

<400>  3064
gtcggcggcg gcggggccgg tcgatggccc gggcggcggc ggcggcatgc ggctcctgtt     60

cctggcggtg ctgcggccac acaccggcaa cgcggtcacg gcccagcgcg ttcgggccca    120

tctagaggct gcagggcacg tgtgcgtttt gaaggatgcc tttgactttg aaagccgatc    180

tgagattgca aacctcatct tggctgagaa ctgcgaggct gccctggctc ttcatctcta    240

taggggaggc aggcttttgc aaggccaccg aatccctttt ggagtcatct ttggtggaac    300

tgatgtaaat gaagatgcca accaggcgga aaaaaacaca gtcatgggca gagttcttga    360

ggaagccaga tttgctgtcg ctttcacaga gtcaatgaag gaaatggcac aagcgcagtg    420

ggtcgatcca gtgtttacaa gggaagtgaa agccaaagtg aaaagagccg ctggggtacg    480

attgattgga gagatgcctc aagaagatct gcacgcggtg gtgaagaatt gcttcgcggt    540

ggtgaatagc tctgtctctg aaggcatgtc agctgcaatt ttggaggcaa tggatttaga    600

agtaccggta ttggccagga acatccccgg gaatgctgcc gtggtgaagc atgaagtcac    660

agggctactg ttttccaatc ctcaggagtt tgttcatctg gcaaagagac tggttagtga    720

tcctgcatta gaaaaggaaa tcgtagtgaa cggaagggaa tacgtgagaa tgtatcattc    780

atggcaggtg gaaagagaca cctaccaaca gctcatcagg aagctggaag gaagcactga    840

agattgaggg ccccgcctca tcagacacct gctctctgac acacagctct gggtgcacac    900

tcagagacag agttctggat cacgtgggcc cagtgcagtt caaataaaac cagcctcagc    960

ggaatcctag aaaatgttag tcgtgagtcc ccagagccac tgcattcatc ccatatcctt   1020

ctgtgcgttc agatgctgtc ccaggcgtgt tcaccagcca gtcctgatgg aggtgcatga   1080

gtgactgggt tgactgggac agggaaaggg gaactggttt tcagggaatt tgggagagaa   1140

tttgattacc tgccttaggg ctttggtgtg gacaatagag gcttattttc aagcagtcat   1200

ggttcagact cctcccgcct gccttctgac caacctctcc ccatcgttgc cagtttgaaa   1260

ggcaaaagca aaacagacgt gtcagctgag ccgagtcctc gcaggatttt tgttgtgatc   1320

tcaggactct gacaggcacg tgggtgaccc gaggcttctc tgaacactag aaagcgctgt   1380

gagtgagctc acgcccggca cagctcactt ttcaatggtg gaattgaaag ttgtgctttt   1440

tagaaaagtg gccaggctgc ccgcaggccc cgcccacctc ttggctgaat ttgagtggaa   1500

aaccaggaag gaacaagcgc cacgtcacgc atagcctgca aatcgcccgc gtgaccctga   1560

gatggaggcc tgaggctttg ggtccagggt gggctcttcc ccttcccaca tcagggaccc   1620

ggggatggat gtcggaaggg tcaccagcct ccagcctttg gcaggatgga gcttgggtct   1680

gcagggcttt gcagccacac agcgaggtca gtccggggcc agccgcgcca tcatggtaat   1740

ggtggcctcg ccccatccat gtcatccatg tcacatgagg acgtgcagtc ttccttgtcc   1800

tctcctagtg gaatttgcct gggagaacct ccactgaata ctgaaattgt tgcatgcctg   1860

tggattcctt acgacaatgg ggaacgcggt gtttcccacc tcttgtgggt agaaagcagt   1920

ctgctttgag gaggcgagaa ggcaaagcca gggcagggcg ttgctgtggg aagcgttcgg   1980

tgaaagcggg tttcgacgct taggagggcc gagggagaag attccaccag cattgtcctt   2040

gcttcaagtt ttaggatgtc tgaactttca gctttcatgt tttcaaccat cattttttta   2100

atggcacaac ctacatcttg tttttaaaag aagtagcctc aaattaaact ccttaaactc   2160

tgatgccctg gggatgagaa caactagctt ggatctcgtg ccgtgtaatt caatgtttca   2220

ttccgctgcc tccatcatgt aatagaatcg ctttccagaa aggcagttaa ctggaagcag   2280

cagaggctcc cagccgtgag aggactgctc aacaatgccc cccatcgccg cccccccacc   2340

cctcgcaccc cttgtgtttt ccctctgagg ggcccaaggg ttatggcttt catgtctagg   2400

tgtggggaca gaggagggag aggcagatcc tgggccggga gaggatggcc tggtctgaat   2460

ctggagtaat taatgccacc caaagaaaag gccctgccag gtccaatgtt gtcttagatc   2520

tgatgatgct gctatttaca aaacactgat cgtccgaaag cttgaatctg ttcctcctcg   2580

aatgaccctg tagatgcctg acctccaccg tacctccaca tcactattca tgtccttcta   2640

ggaaaatgtg cacatgcctc acgcactatg tgggaagggc gtgtttttaa attaataaag   2700

tgtgtcacca ttagccatac g                                             2721


<210>  3065
<211>  266
<212>  PRT
<213>  Homosapiens

<400>  3065

Met Arg Leu Leu Phe Leu Ala Val Leu Arg Pro His Thr Gly Asn Ala 
1               5                   10                  15      


Val Thr Ala Gln Arg Val Arg Ala His Leu Glu Ala Ala Gly His Val 
            20                  25                  30          


Cys Val Leu Lys Asp Ala Phe Asp Phe Glu Ser Arg Ser Glu Ile Ala 
        35                  40                  45              


Asn Leu Ile Leu Ala Glu Asn Cys Glu Ala Ala Leu Ala Leu His Leu 
    50                  55                  60                  


Tyr Arg Gly Gly Arg Leu Leu Gln Gly His Arg Ile Pro Phe Gly Val 
65                  70                  75                  80  


Ile Phe Gly Gly Thr Asp Val Asn Glu Asp Ala Asn Gln Ala Glu Lys 
                85                  90                  95      


Asn Thr Val Met Gly Arg Val Leu Glu Glu Ala Arg Phe Ala Val Ala 
            100                 105                 110         


Phe Thr Glu Ser Met Lys Glu Met Ala Gln Ala Gln Trp Val Asp Pro 
        115                 120                 125             


Val Phe Thr Arg Glu Val Lys Ala Lys Val Lys Arg Ala Ala Gly Val 
    130                 135                 140                 


Arg Leu Ile Gly Glu Met Pro Gln Glu Asp Leu His Ala Val Val Lys 
145                 150                 155                 160 


Asn Cys Phe Ala Val Val Asn Ser Ser Val Ser Glu Gly Met Ser Ala 
                165                 170                 175     


Ala Ile Leu Glu Ala Met Asp Leu Glu Val Pro Val Leu Ala Arg Asn 
            180                 185                 190         


Ile Pro Gly Asn Ala Ala Val Val Lys His Glu Val Thr Gly Leu Leu 
        195                 200                 205             


Phe Ser Asn Pro Gln Glu Phe Val His Leu Ala Lys Arg Leu Val Ser 
    210                 215                 220                 


Asp Pro Ala Leu Glu Lys Glu Ile Val Val Asn Gly Arg Glu Tyr Val 
225                 230                 235                 240 


Arg Met Tyr His Ser Trp Gln Val Glu Arg Asp Thr Tyr Gln Gln Leu 
                245                 250                 255     


Ile Arg Lys Leu Glu Gly Ser Thr Glu Asp 
            260                 265     


<210>  3066
<211>  5815
<212>  DNA
<213>  Homosapiens

<400>  3066
ggccactctt cgctcgggta aacaggaaag gaaatacccc ttgtggatta aaatttaaaa     60

aaaattctgt tggggtcgaa ggagggaggt ggggtttgcc tgcgcgcgtg ttggactccg    120

gagagcaact caggagcccg cgcggtcgtc gcctcccggc ctggccatgg actggcggga    180

agagggagca gggcgcccgg gctgctcggg cccctagccg ggcgctccct cgccaccggc    240

cccgctgcgg gcctctaggg gactgagacg gtctcttgtt cgcctggacg gcgccgggga    300

gcggaggatc tgcgctccgg gtctccagga tgtgcccgtc tgagatgggg acgctgtggc    360

accactggtc gccggtactc atcagcctgg ccgccctgtt ttccaaagtg acggaaggtc    420

gagggatcct tgagagcatc cagaggtttt ccttgctgcc cacctacctc cccgtgacct    480

accacatcaa caacgcggac gtctccttct tcctgaagga ggccaaccag gatatcatga    540

ggaactccag cctgcagtcc cgggtggagt catttctgat ttacaaatcc aggaggctgc    600

ctgtcctcaa tgccagctac gggcctttct ccatcgagca agtggtgccc caggatttaa    660

tgctaccttc caacccattt ggattcacca acaaattttc tcttaactgg aaactaaaag    720

cccacatcct gcgggacaaa gtctacctga gccggcccaa agtgcaggtt ctgttccaca    780

tcatgggcag agactgggac gaccgcagcg ccggggagaa gctgccgtgc ctgagggtct    840

ttgctttccg agagacccga gaggtgcggg gcagctgccg gctgcagggg gacctggggc    900

tgtgcgtggc cgagctggag ctcctgtcca gctggttcag cccccccacg gtggttgccg    960

ggaggaggaa gtccgtggac cagccggagg ggacccccgt ggagctctac tacaccgtgc   1020

acccaggggg tgagagaggg gactgcgtca gggaagacgc gaggagaagc aatgggatcc   1080

ggacaggcca cagtgacatc gatgagtccg ggcccccctt gcagaggatc gggagcatct   1140

tcctttatca gacacacagg aaaccctccc tgagagaact gcgtctggac aacagcgtgg   1200

ccatccacta tataccaaag accgtgagga aaggagacgt gctgactttt cctgtttcca   1260

tctccagaaa ttccactgaa gatcgcttca cgttgagggc aaaggtgaag aaaggcgtga   1320

acatcatcgg cgtgcgagcc agcagccctt ccatttggga tgtcaaggag cgcacggatt   1380

atactggaaa gtatgcacca gctgtcatcg tttgtcagaa gaaagcagct ggctcagaaa   1440

acagtgcgga tggcgcctcc tacgaggtca tgcagatcga tgtggaggtg gaagagcctg   1500

gtgacctgcc agccacacag ctggtcacgt ggcaggtcga gtaccccgga gagatcacgt   1560

ctgacttggg agtgtccaag atctatgtga gcccaaagga cttgattgga gttgtgccgc   1620

tggctatgga ggcagaaatc ctgaacacag ccatcctcac ggggaagacg gtggccgtcc   1680

cggtgaaagt ggtctccgtg gaggacgacg gcacagtgac agagctgctg gagtctgtgg   1740

agtgtagatc gtctgatgaa gacgtgatta aggtttctga cagatgtgac tacgtctttg   1800

tcaatgggaa agaaatgaaa ggcaaggtca acgtggtggt gaacttcacc taccagcacc   1860

tgagcagccc cctggagatg acggtgtggg tgccccggct tccgctgcag atcgaggtct   1920

ccgacaccga gctcaatcag atcaagggtt ggagagtgcc catcgtctcc agcaggaggc   1980

ctgccgggga cagtgaagag gaggaggatg atgagcggag gggccgcggc tgcaccctgc   2040

agtaccagca cgccatggtg cgggtcctga cgcagtttgt ggctgaagcg gccggccctg   2100

ggggacacct ggcccacctg ctgggctcag actggcaagt ggacatcacg gagctgataa   2160

atgacttcat gcaggtggag gagcccagga tcgccaagct gcaaggcgga cagattctga   2220

tggggcagga gcttgggatg accaccattc agatcctgtc tcctctgtca gacaccatcc   2280

tcgctgaaaa gaccatcact gtgctggacg agaaggtgac catcacagac ctcggggtgc   2340

agctggtgac agggctgtca ctctccttgc agctcagccc aggaagcaac agggccatct   2400

ttgccactgc agtgactcag gaacttctgc agaggccaaa acaggaagca gccatcagtt   2460

gctgggtcca gttcagtgat ggctcagtca cgcccttgga tatttacgat gggaaagact   2520

tctccttgat ggccacatct ttggatgaga aggtagtctc catccaccaa gaccccaaat   2580

tcaagtggcc tatcattgct gcggaaacag aaggacaagg caccctggtc aaggtggaaa   2640

tggttattag tgaatcctgc cagaaatcca agcggaagag tgtgttagct gttggaacgg   2700

caaacatcaa agttaaattt ggccaaaacg atgctaaccc caacaccagt gacagcagac   2760

acacaggggc aggggttcac atggaaaaca atgtcagtga cagaaggccc aaaaaaccct   2820

cgcaggaatg ggggagtcag gaaggacagt actatggcag ttcttctatg ggactcatgg   2880

agggacgggg caccacgaca gacaggtcca tcctgcagaa gaagaaaggc caggaaagcc   2940

ttttagatga caacagccac ttgcagacca tccccagcga cctcaccagc ttcccagccc   3000

aggtggacct ccccagaagc aatggggaaa tggatgggaa tgaccttatg caggcatcca   3060

aagggctgag cgacttagaa attgggatgt atgctttgtt gggagtcttc tgtttggcca   3120

ttttggtctt cttgataaac tgtgtgacct ttgcattaaa atacagacac aaacaggttc   3180

ccttcgagga gcaggaaggg atgagtcact ctcatgactg ggttgggtta agcaaccgga   3240

cagagctgtt ggagaatcac atcaactttg cctcctcgca agatgagcaa atcactgcca   3300

ttgacagggg catggatttc gaggaaagta aatatctcct cagcacaaac tcccaaaaaa   3360

gcatcaatgg gcagctgttc aaacctttgg gacccatcat cattgatggg aaagatcaga   3420

aaagtgagcc cccaacatcc cctacctcaa aaaggaaaag ggtaaaattt accaccttca   3480

ccgccgtctc ctcagacgac gagtacccca ccaggaactc catcgtgatg agtagcgagg   3540

atgacattaa gtgggtctgc caggatctgg accctgggga ctgcaaagag ctgcacaact   3600

acatggagag gttacatgaa aatgtgtaag ccagacacac acagacattg gttctcactc   3660

acctttcagc ctttaattcc aggatgtgta gcaacggtgc ccccggaaga gaaacaaagc   3720

agcaggacaa aataaggatg acactatcca tacagcctca gccaatgacc ccggctcggc   3780

ggcgaggcct ggagtccgca tcgacgcaca cattccagag tacagtgtct tgcttaagag   3840

gtttatcatg catggcaaga tttttaagac ttgaaacaaa aacgagttct gaatcactga   3900

gcgtctgaga gcgtccagga aagaacagcc tctctctctc gaatcaaagc aatttggata   3960

ttgtaaaatc cacatggctc caatattcaa tattgcagac tatggaagaa aagtacaact   4020

caggtggagc atccatggat cgcatccatg gatcgcatcc atggatcaat gggaggaagc   4080

gtgtcatcga aactggagca gcacatcttg ctgtgagcgc gatcacaggc agtccagtgc   4140

cgccgtcagc tgtgggaggc atgattgtga gtcactgtct ctcaaaggct gggccagagc   4200

tgtctcagat catggacagg ccaaggaagt ggctgacaag gactgaaagg gaacatgtgg   4260

gctaacaggc cacaaatacc tttgtaacta catgccaagg acaaacacat ggacgcaaat   4320

cctctgagcc cttcagggta cttctttatt tgtaaactaa ggatactggg catagaattt   4380

gaatcaggtt caaagaacca cgctcttttg attcatatca agttcacaat gtatccattt   4440

ctattcctcc actgcattgc catcctcccc aaagccgttg gtcacctgtg ggtgggggag   4500

ggagagggca gtttgtagta tttgctgggt cttttttctc cccctgggtt ttgtgtcaac   4560

tcccaagtga cattctgtag agaagctccc cccgcaacct gggcatatgc cccacgccgt   4620

ccgtctttga agaggctggt ctctaggcat gggcggtagt cacggtgaat tccataccag   4680

gggatataca ttcccttgct ttactagaaa gaaaacaggg ccacttggga tgggtctttc   4740

actgttcatg gcagatctcc tgtccaaaga tgtggcctcg aggctgttga gacaaatcgg   4800

ggtgcctgtg tggaacgtgc agggcgtgtg gagttggggg ggttctgggt gtgaaagtgg   4860

tggatccagc aggaagccca gcctcacaca caccggacag cacagaaacc ttcttcatct   4920

tggaggtgcg aagggataag gggcatcagt gcatgtggtg aagatgcagg tttgcaagca   4980

cttggtcctg cagtcagccc cgaaaggttc agcattgctt aagaccagcc atgactctgg   5040

atatccctga atcccttcac ttatgaagcc tatgaagatg ggggcaagga tacatcagag   5100

aattcctgcc tcatctcacg ctcactccaa ggtagagaat ggtgtgttgg gtgattgcca   5160

gccagatagg atcctgcgaa agatggtcgg gggcagcggg tggtgggcag aagaggccgt   5220

gctgttgaat tgatcttcta tttttccctc tggtcatttt ctctctctct ctgctcttca   5280

gttgtctgtt ttccagtctc tctgtgtgtc tgtctctgta tctctctcct cctttgaacc   5340

tatcttctcc ctgcttcctc tccatctcat ctctgtaatt ttgagtgtgt gtctttactc   5400

cttcttcctc tccatagaat tgaattctct ttagatcatg tgtgtgtaaa tttcaccagt   5460

ttaccctccc aaccttagcc ctctcccctg caactgtggt gctcttgaga ctgaggtttc   5520

tgcagccagt aagtcacctg ctcctgtccg caagcttacc taccttgttt ggttgggtga   5580

ttaagctgtc accccttttc aatgagaatc ctttgctttc agtaacgtcc tcatatttct   5640

ttccattctt acctgtgtca tgttctgttg aatactgcag ccgctgcccg cttccaaatc   5700

catctgcgtg tagaatgtac tgtagattgt aagaatgtaa tatatattta taaacttact   5760

gactgtaaat ataaagtttg cattcagtga caaaaaaaaa aaaaaaaaaa aaaaa        5815


<210>  3067
<211>  1099
<212>  PRT
<213>  Homosapiens

<400>  3067

Met Cys Pro Ser Glu Met Gly Thr Leu Trp His His Trp Ser Pro Val 
1               5                   10                  15      


Leu Ile Ser Leu Ala Ala Leu Phe Ser Lys Val Thr Glu Gly Arg Gly 
            20                  25                  30          


Ile Leu Glu Ser Ile Gln Arg Phe Ser Leu Leu Pro Thr Tyr Leu Pro 
        35                  40                  45              


Val Thr Tyr His Ile Asn Asn Ala Asp Val Ser Phe Phe Leu Lys Glu 
    50                  55                  60                  


Ala Asn Gln Asp Ile Met Arg Asn Ser Ser Leu Gln Ser Arg Val Glu 
65                  70                  75                  80  


Ser Phe Leu Ile Tyr Lys Ser Arg Arg Leu Pro Val Leu Asn Ala Ser 
                85                  90                  95      


Tyr Gly Pro Phe Ser Ile Glu Gln Val Val Pro Gln Asp Leu Met Leu 
            100                 105                 110         


Pro Ser Asn Pro Phe Gly Phe Thr Asn Lys Phe Ser Leu Asn Trp Lys 
        115                 120                 125             


Leu Lys Ala His Ile Leu Arg Asp Lys Val Tyr Leu Ser Arg Pro Lys 
    130                 135                 140                 


Val Gln Val Leu Phe His Ile Met Gly Arg Asp Trp Asp Asp Arg Ser 
145                 150                 155                 160 


Ala Gly Glu Lys Leu Pro Cys Leu Arg Val Phe Ala Phe Arg Glu Thr 
                165                 170                 175     


Arg Glu Val Arg Gly Ser Cys Arg Leu Gln Gly Asp Leu Gly Leu Cys 
            180                 185                 190         


Val Ala Glu Leu Glu Leu Leu Ser Ser Trp Phe Ser Pro Pro Thr Val 
        195                 200                 205             


Val Ala Gly Arg Arg Lys Ser Val Asp Gln Pro Glu Gly Thr Pro Val 
    210                 215                 220                 


Glu Leu Tyr Tyr Thr Val His Pro Gly Gly Glu Arg Gly Asp Cys Val 
225                 230                 235                 240 


Arg Glu Asp Ala Arg Arg Ser Asn Gly Ile Arg Thr Gly His Ser Asp 
                245                 250                 255     


Ile Asp Glu Ser Gly Pro Pro Leu Gln Arg Ile Gly Ser Ile Phe Leu 
            260                 265                 270         


Tyr Gln Thr His Arg Lys Pro Ser Leu Arg Glu Leu Arg Leu Asp Asn 
        275                 280                 285             


Ser Val Ala Ile His Tyr Ile Pro Lys Thr Val Arg Lys Gly Asp Val 
    290                 295                 300                 


Leu Thr Phe Pro Val Ser Ile Ser Arg Asn Ser Thr Glu Asp Arg Phe 
305                 310                 315                 320 


Thr Leu Arg Ala Lys Val Lys Lys Gly Val Asn Ile Ile Gly Val Arg 
                325                 330                 335     


Ala Ser Ser Pro Ser Ile Trp Asp Val Lys Glu Arg Thr Asp Tyr Thr 
            340                 345                 350         


Gly Lys Tyr Ala Pro Ala Val Ile Val Cys Gln Lys Lys Ala Ala Gly 
        355                 360                 365             


Ser Glu Asn Ser Ala Asp Gly Ala Ser Tyr Glu Val Met Gln Ile Asp 
    370                 375                 380                 


Val Glu Val Glu Glu Pro Gly Asp Leu Pro Ala Thr Gln Leu Val Thr 
385                 390                 395                 400 


Trp Gln Val Glu Tyr Pro Gly Glu Ile Thr Ser Asp Leu Gly Val Ser 
                405                 410                 415     


Lys Ile Tyr Val Ser Pro Lys Asp Leu Ile Gly Val Val Pro Leu Ala 
            420                 425                 430         


Met Glu Ala Glu Ile Leu Asn Thr Ala Ile Leu Thr Gly Lys Thr Val 
        435                 440                 445             


Ala Val Pro Val Lys Val Val Ser Val Glu Asp Asp Gly Thr Val Thr 
    450                 455                 460                 


Glu Leu Leu Glu Ser Val Glu Cys Arg Ser Ser Asp Glu Asp Val Ile 
465                 470                 475                 480 


Lys Val Ser Asp Arg Cys Asp Tyr Val Phe Val Asn Gly Lys Glu Met 
                485                 490                 495     


Lys Gly Lys Val Asn Val Val Val Asn Phe Thr Tyr Gln His Leu Ser 
            500                 505                 510         


Ser Pro Leu Glu Met Thr Val Trp Val Pro Arg Leu Pro Leu Gln Ile 
        515                 520                 525             


Glu Val Ser Asp Thr Glu Leu Asn Gln Ile Lys Gly Trp Arg Val Pro 
    530                 535                 540                 


Ile Val Ser Ser Arg Arg Pro Ala Gly Asp Ser Glu Glu Glu Glu Asp 
545                 550                 555                 560 


Asp Glu Arg Arg Gly Arg Gly Cys Thr Leu Gln Tyr Gln His Ala Met 
                565                 570                 575     


Val Arg Val Leu Thr Gln Phe Val Ala Glu Ala Ala Gly Pro Gly Gly 
            580                 585                 590         


His Leu Ala His Leu Leu Gly Ser Asp Trp Gln Val Asp Ile Thr Glu 
        595                 600                 605             


Leu Ile Asn Asp Phe Met Gln Val Glu Glu Pro Arg Ile Ala Lys Leu 
    610                 615                 620                 


Gln Gly Gly Gln Ile Leu Met Gly Gln Glu Leu Gly Met Thr Thr Ile 
625                 630                 635                 640 


Gln Ile Leu Ser Pro Leu Ser Asp Thr Ile Leu Ala Glu Lys Thr Ile 
                645                 650                 655     


Thr Val Leu Asp Glu Lys Val Thr Ile Thr Asp Leu Gly Val Gln Leu 
            660                 665                 670         


Val Thr Gly Leu Ser Leu Ser Leu Gln Leu Ser Pro Gly Ser Asn Arg 
        675                 680                 685             


Ala Ile Phe Ala Thr Ala Val Thr Gln Glu Leu Leu Gln Arg Pro Lys 
    690                 695                 700                 


Gln Glu Ala Ala Ile Ser Cys Trp Val Gln Phe Ser Asp Gly Ser Val 
705                 710                 715                 720 


Thr Pro Leu Asp Ile Tyr Asp Gly Lys Asp Phe Ser Leu Met Ala Thr 
                725                 730                 735     


Ser Leu Asp Glu Lys Val Val Ser Ile His Gln Asp Pro Lys Phe Lys 
            740                 745                 750         


Trp Pro Ile Ile Ala Ala Glu Thr Glu Gly Gln Gly Thr Leu Val Lys 
        755                 760                 765             


Val Glu Met Val Ile Ser Glu Ser Cys Gln Lys Ser Lys Arg Lys Ser 
    770                 775                 780                 


Val Leu Ala Val Gly Thr Ala Asn Ile Lys Val Lys Phe Gly Gln Asn 
785                 790                 795                 800 


Asp Ala Asn Pro Asn Thr Ser Asp Ser Arg His Thr Gly Ala Gly Val 
                805                 810                 815     


His Met Glu Asn Asn Val Ser Asp Arg Arg Pro Lys Lys Pro Ser Gln 
            820                 825                 830         


Glu Trp Gly Ser Gln Glu Gly Gln Tyr Tyr Gly Ser Ser Ser Met Gly 
        835                 840                 845             


Leu Met Glu Gly Arg Gly Thr Thr Thr Asp Arg Ser Ile Leu Gln Lys 
    850                 855                 860                 


Lys Lys Gly Gln Glu Ser Leu Leu Asp Asp Asn Ser His Leu Gln Thr 
865                 870                 875                 880 


Ile Pro Ser Asp Leu Thr Ser Phe Pro Ala Gln Val Asp Leu Pro Arg 
                885                 890                 895     


Ser Asn Gly Glu Met Asp Gly Asn Asp Leu Met Gln Ala Ser Lys Gly 
            900                 905                 910         


Leu Ser Asp Leu Glu Ile Gly Met Tyr Ala Leu Leu Gly Val Phe Cys 
        915                 920                 925             


Leu Ala Ile Leu Val Phe Leu Ile Asn Cys Val Thr Phe Ala Leu Lys 
    930                 935                 940                 


Tyr Arg His Lys Gln Val Pro Phe Glu Glu Gln Glu Gly Met Ser His 
945                 950                 955                 960 


Ser His Asp Trp Val Gly Leu Ser Asn Arg Thr Glu Leu Leu Glu Asn 
                965                 970                 975     


His Ile Asn Phe Ala Ser Ser Gln Asp Glu Gln Ile Thr Ala Ile Asp 
            980                 985                 990         


Arg Gly Met Asp Phe Glu Glu Ser  Lys Tyr Leu Leu Ser  Thr Asn Ser 
        995                 1000                 1005             


Gln Lys  Ser Ile Asn Gly Gln  Leu Phe Lys Pro Leu  Gly Pro Ile 
    1010                 1015                 1020             


Ile Ile  Asp Gly Lys Asp Gln  Lys Ser Glu Pro Pro  Thr Ser Pro 
    1025                 1030                 1035             


Thr Ser  Lys Arg Lys Arg Val  Lys Phe Thr Thr Phe  Thr Ala Val 
    1040                 1045                 1050             


Ser Ser  Asp Asp Glu Tyr Pro  Thr Arg Asn Ser Ile  Val Met Ser 
    1055                 1060                 1065             


Ser Glu  Asp Asp Ile Lys Trp  Val Cys Gln Asp Leu  Asp Pro Gly 
    1070                 1075                 1080             


Asp Cys  Lys Glu Leu His Asn  Tyr Met Glu Arg Leu  His Glu Asn 
    1085                 1090                 1095             


Val 
    


<210>  3068
<211>  501
<212>  DNA
<213>  Homosapiens

<400>  3068
cccaccgcct ccttctggat ggcaggtgtc cctctcggct gagcaggtgt ctgggaccat     60

gacatccaac ctgggctctc ctggccccca gagaagagct gcccagtgca tgtgctggct    120

gcaccgtgac gtcccctatg aacgaggccc acaggcagtg gctggctggg gggatgcccc    180

tgccctgagc tggagtctcc ccaggtggct gcttcttccc caccccgagg gtcacagccc    240

agcccaagct ccaagggaat ggagcagctg cctgcaccaa gcttccctcc tctggagaaa    300

gcacctcctc ttctccctca cgtgctccct gatgaccgcc aggctccttg acatggttcc    360

caggaccagc ctctcccagg gtccctactc ccagtacccc agtcctcacc atttgtgacc    420

cttcagcccc tgctgaaccc tgccagcccc aggacaggcc acagctgtca tgccacctcc    480

cagccatgat gaatggggaa c                                              501


<210>  3069
<211>  119
<212>  PRT
<213>  Homosapiens

<400>  3069

Met Thr Ser Asn Leu Gly Ser Pro Gly Pro Gln Arg Arg Ala Ala Gln 
1               5                   10                  15      


Cys Met Cys Trp Leu His Arg Asp Val Pro Tyr Glu Arg Gly Pro Gln 
            20                  25                  30          


Ala Val Ala Gly Trp Gly Asp Ala Pro Ala Leu Ser Trp Ser Leu Pro 
        35                  40                  45              


Arg Trp Leu Leu Leu Pro His Pro Glu Gly His Ser Pro Ala Gln Ala 
    50                  55                  60                  


Pro Arg Glu Trp Ser Ser Cys Leu His Gln Ala Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Lys His Leu Leu Phe Ser Leu Thr Cys Ser Leu Met Thr Ala Arg Leu 
                85                  90                  95      


Leu Asp Met Val Pro Arg Thr Ser Leu Ser Gln Gly Pro Tyr Ser Gln 
            100                 105                 110         


Tyr Pro Ser Pro His His Leu 
        115                 


<210>  3070
<211>  1630
<212>  DNA
<213>  Homosapiens

<400>  3070
gttgctgaag cttcatcctt tgctctcatt ctgtaagtca tagaaaagtt tgaaacattc     60

tgtctgtggt agagctcggg ccagctgtag ttcattcgcc agtgtgcttt tcttaatatc    120

taagatggtg cgtgagcagt acactacagc cacagaaggc atctgcatag agaggccaga    180

gaatcagtat gtctacaaaa ttggcattta tggctggaga aagcgctgtc tctacttgtt    240

tgttcttctt ttactcatca tcctcgttgt gaatttagct cttacaattt ggattcttaa    300

agtgatgtgg ttttctccag caggaatggg ccacttgtgt gtaacaaaag atggactgcg    360

cttggaaggg gaatcagaat ttttattccc attgtatgcc aaagaaatac actccagagt    420

ggactcatct ctgctgctac aatcaaccca gaatgtgact gtaaatgcgc gcaactcaga    480

aggggaggtc acaggcaggt taaaagtcgg tcccaaaatg gtagaagtcc agaatcaaca    540

gtttcagatc aactccaacg acggcaagcc actatttact gtagatgaga aggaagttgt    600

ggttggtaca gataaacttc gagtaactgg gcctgaaggg gctctttttg aacattcagt    660

ggagacaccc cttgtcagag ccgacccgtt tcaagacctt agattagaat cccccactcg    720

gagtctaagc atggatgccc caaggggtgt gcatattcaa gctcacgctg ggaaaattga    780

ggcgctttct caaatggata ttctttttca tagtagtgat ggaatgcttg tgcttgatgc    840

tgaaactgtg tgcttaccca agctggtgca ggggacgtgg ggtccctctg gcagctcaca    900

gagcctctac gaaatctgtg tgtgtccaga tgggaagctg tacctgtctg tggccggtgt    960

gagcaccacg tgccaggagc acagccacat ctgcctctga gctgcctgcg tcctctcggt   1020

gagctgtgca gtgccggccc cagatcctca cacccaggga gcagctgcac atcgtgaaag   1080

actgaggcag cgtggatggg aagtaaacgc ttccagagga actcagaaaa aattatgtgc   1140

cagtgaaagt gtttggacaa aaactacatg atctcaaaat gcacgtggat gtgagacaca   1200

aaagttgaca aaatggaaaa gcaatgtgtt tttccactgg attaattttc accggaacaa   1260

ttgcgaattc tctctgcctc gcctccccct atcttgtccg tgtgggcaca cactgagtgt   1320

tgagttgccg tgtggagtta atgtatgacg ctccactgtg gatatctaat gccctgttga   1380

gagtagcctt gctcagtact aaaatgcccc aaagttctat acagcatttc ctttatagca   1440

ttcaaacctc acatcctccc ttcagtttaa tgcaagtaag tcaggtttca caagaaaatt   1500

ttcaagtttt gaagggaatt tgaggttgat ctggttttca agatgtagtt aaaggaataa   1560

atcactcaaa attaaacttt ctgtatatag tcaataagca ataaaaacct catttttcag   1620

agttaaaaaa                                                          1630


<210>  3071
<211>  291
<212>  PRT
<213>  Homosapiens

<400>  3071

Met Val Arg Glu Gln Tyr Thr Thr Ala Thr Glu Gly Ile Cys Ile Glu 
1               5                   10                  15      


Arg Pro Glu Asn Gln Tyr Val Tyr Lys Ile Gly Ile Tyr Gly Trp Arg 
            20                  25                  30          


Lys Arg Cys Leu Tyr Leu Phe Val Leu Leu Leu Leu Ile Ile Leu Val 
        35                  40                  45              


Val Asn Leu Ala Leu Thr Ile Trp Ile Leu Lys Val Met Trp Phe Ser 
    50                  55                  60                  


Pro Ala Gly Met Gly His Leu Cys Val Thr Lys Asp Gly Leu Arg Leu 
65                  70                  75                  80  


Glu Gly Glu Ser Glu Phe Leu Phe Pro Leu Tyr Ala Lys Glu Ile His 
                85                  90                  95      


Ser Arg Val Asp Ser Ser Leu Leu Leu Gln Ser Thr Gln Asn Val Thr 
            100                 105                 110         


Val Asn Ala Arg Asn Ser Glu Gly Glu Val Thr Gly Arg Leu Lys Val 
        115                 120                 125             


Gly Pro Lys Met Val Glu Val Gln Asn Gln Gln Phe Gln Ile Asn Ser 
    130                 135                 140                 


Asn Asp Gly Lys Pro Leu Phe Thr Val Asp Glu Lys Glu Val Val Val 
145                 150                 155                 160 


Gly Thr Asp Lys Leu Arg Val Thr Gly Pro Glu Gly Ala Leu Phe Glu 
                165                 170                 175     


His Ser Val Glu Thr Pro Leu Val Arg Ala Asp Pro Phe Gln Asp Leu 
            180                 185                 190         


Arg Leu Glu Ser Pro Thr Arg Ser Leu Ser Met Asp Ala Pro Arg Gly 
        195                 200                 205             


Val His Ile Gln Ala His Ala Gly Lys Ile Glu Ala Leu Ser Gln Met 
    210                 215                 220                 


Asp Ile Leu Phe His Ser Ser Asp Gly Met Leu Val Leu Asp Ala Glu 
225                 230                 235                 240 


Thr Val Cys Leu Pro Lys Leu Val Gln Gly Thr Trp Gly Pro Ser Gly 
                245                 250                 255     


Ser Ser Gln Ser Leu Tyr Glu Ile Cys Val Cys Pro Asp Gly Lys Leu 
            260                 265                 270         


Tyr Leu Ser Val Ala Gly Val Ser Thr Thr Cys Gln Glu His Ser His 
        275                 280                 285             


Ile Cys Leu 
    290     


<210>  3072
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3072
gtcgatttgg tcagacaacg ccaccacttg ttgattttct caaggacatt ttgagaagat     60

atccagaagg aggacagatt cttaaggaat taattcagaa tgcagaagat gctggggcga    120

cagaagttaa atttttatat gatgaaactc aatacggaac agagactctt tggtcaaaag    180

atatggcgcc atatcagggg ccagctctct atgtgtacaa caacgcggtt ttcaccccag    240

aggactggca cggcattcaa gaaatagcaa gaagcaggaa aaaggatgat cctctgaagg    300

tcggaagatt tggaattggg tttaattctg tctatcatat aacagatgtt ccttgtatct    360

ttagtggtga ccaaatcggg atgctagatc ctcatcaaac actttttggc ccacatgaat    420

caggccaatg ttggaatctc aaagatgaca gcaaagaaat tagtgaactt tcagaccagt    480

ttgcaccatt tgttggcatt tttggaagca ccaaggaaac atttataaac ggcaattttc    540

caggaacatt tttccgtttc cctcttcgcc tacaaccttc acaacttagt agtaacctct    600

acaataagca gaaggttctt gagttgtttg agtcttttag ggcagatgca gacacagtgc    660

tgctctttct gaaaagtgtg caggatgttt ccttatatgt ccgagaggct gacggaacag    720

agaaactggt gtttagagtg acttcgagtg agagtaaggc actgaaacat gagcggccga    780

attctataaa gattctggga actgctataa gtaactattg taaaaagact ccaagcaata    840

acatcacctg tgtaacatat cacgtaaata ttgttttaga agaggagagt actaaggatg    900

cacagaaaac atcttggttg gtgtgtaaca gtgtgggtgg gcgagggatc agtagtaagc    960

ttgactcttt agctgatgaa ctgaaatttg tcccaatcat tggaatagcc atgcctttat   1020

caagcagaga tgatgaagca aaaggagcaa cgtctgattt ctcaggaaaa gcattttgtt   1080

tccttccttt accacctggt gaggaaagca gcacaggcct cccagttcac atcagtgggt   1140

tctttggcct tactgataac cgcaggagca taaaatggag agagctggac cagtggagag   1200

acccggcagc cttatggaat gagtttcttg tcatgaatgt tgtccccaaa gcttatgcta   1260

ctctgatctt agattcaata aaacgtctgg agatggaaaa gagctctgat ttccccttgt   1320

cagttgatgt tatctataag ctttggccgg aggcgagcaa agtcaaggtg cactggcaac   1380

cggtgttaga gcctctattc agcgagctgt tgcagaatgc agtgatttat tcaattagct   1440

gtgactgggt caggttggag caggtgtact tctcagaact tgatgaaaat ttagaataca   1500

caaaaactgt gctcaactac ctccagagct cagggaagca gattgccaag gtaccaggga   1560

atgtggatgc tgctgttcag ctcacagctg cctctggcac aacacctgtg aggaaggtga   1620

cgcccgcgtg ggtgcggcag gtgctgcgga agtgtgcaca cctgggctgt gctgaagaaa   1680

agcttcacct tctagaattt gtgctttctg accaagccta cagtgagctg cttgggctgg   1740

agctgctccc tttacaaaat ggcaattttg tccccttctc ctcatctgta tcagaccaag   1800

atgtcattta tattacctca gcagaatatc caaggtccct tttcccaagt cttgaaggaa   1860

gatttatttt ggataacttg aaacctcacc ttgtggctgc tttaaaggaa gctgcccaaa   1920

cccgaggaag accatgtact cagctgcagc ttctaaatcc agaacgattt gcacgtctta   1980

tcaaggaagt aatgaataca ttctggcctg gcagagaatt gattgttcaa tggtatccat   2040

ttgatgaaaa cagaaatcac ccatctgttt catggcttaa gatggtttgg aaaaatcttt   2100

atatacattt ttcagaggat ttgactttat ttgatgagat gccacttatc cccagaacta   2160

tactagagga aggtcagaca tgtgtggaac tcattagact caggattcca tcgttagtca   2220

ttttagacga tgaatctgaa gcacagcttc cagaattttt agcagacatt gtacaaaaac   2280

ttggagggtt tgtccttaaa aaattagatg catctataca acatccgctt attaaaaaat   2340

atattcattc accattacca agtgctgttt tgcagataat ggagaagatg ccattgcaga   2400

aattgtgtaa tcaaataact tcgctacttc caacacacaa agatgccctg aggaagttct   2460

tggctagttt aaccgatagc agtgagaaag agaaaagaat tattcaagaa ttggcaatat   2520

tcaagcgcat taaccattct tctgatcagg gaatttcctc ttatacaaaa ttgaaaggtt   2580

gtaaagtctt acaccatact gccaaactcc cagcagatct gcgactttct atttcagtaa   2640

tagacagtag tgatgaagct actattcgtc tggcaaacat gttgaaaata gaacagttaa   2700

agaccactag ctgcttaaag cttgttttaa aagatattga aaatgcattt tattcacatg   2760

aagaggtaac acagcttatg ttatgggtcc ttgagaatct atcttctctt aaaaatgaga   2820

atccaaatgt gcttgagtgg ttaacaccat taaaattcat ccagatatca caggaacaga   2880

tggtatcagc tggtgaactc tttgaccctg atatagaagt actaaaggat ctcttttgta   2940

atgaagaagg aacctatttc ccaccctcag tttttacctc accagatatt cttcactcct   3000

taagacagat tggtttaaaa aacgaagcca gtctcaaaga aaaggatgtt gtgcaagtgg   3060

caaaaaaaat tgaagcctta caggtcggtg cttgtcctga tcaagatgtt cttctgaaga   3120

aagccaaaac cctcttactg gttttaaata agaatcacac actgttgcaa tcatctgaag   3180

gaaagatgac attgaagaaa ataaaatggg ttccagcctg caaggaaagg cctccaaatt   3240

atccaggctc tttggtctgg aaaggagatc tctgtaatct ctgtgcacca ccagatatgt   3300

gtgatgtagg ccatgcaatt ctcattggct cctcacttcc tcttgttgaa agtatccatg   3360

taaacctgga aaaagcatta gggatcttca caaaacctag ccttagtgct gtcttaaaac   3420

actttaaaat tgttgttgat tggtattctt caaaaacctt tagtgatgaa gactactatc   3480

aattccagca tattttgctt gagatttacg gattcatgca tgatcatcta aatgaaggga   3540

aagattcttt tagagcctta aaatttccat gggtttggac tggcaaaaag ttttgtccac   3600

ttgcccaggc tgtgattaaa ccaatccatg atcttgacct tcagccttat ttgcataatg   3660

tacctaaaac catggcaaaa ttccaccaac tatttaaggt ctgtggttca atagaggagt   3720

tgacatcaga tcatatttcc atggttattc agaagatata tctcaaaagt gaccaagatc   3780

tcagtgaaca agaaagcaaa caaaatcttc atcttatgtt gaatattatc agatggctgt   3840

atagcaatca gattccagca agccccaaca caccagttcc tatacatcat agcaaaaatc   3900

cttctaaact tatcatgaag ccaattcacg aatgctgtta ttgtgacatt aaagttgatg   3960

accttaatga cttacttgaa gattctgtgg aaccaatcat tttggtgcat gaggacatac   4020

ccatgaaaac tgcagaatgg ctaaaagttc catgccttag tacaagactg ataaatcctg   4080

aaaacatggg atttgagcag tcaggacaaa gagagccact tactgtaaga attaaaaata   4140

ttctggaaga atacccttca gtgtcagata tttttaaaga actacttcaa aacgctgatg   4200

atgcaaatgc aacagaatgc agtttcttga ttgatatgag aagaaatatg gacataagag   4260

agaatctcct agacccaggg atggcagctt gtcatggacc tgctttgtgg tcattcaaca   4320

attctcaatt ctcagattca gattttgtga acataactag gttaggagaa tctttaaaaa   4380

ggggagaagt tgacaaagtt ggaaaatttg gtcttggatt taattctgtg taccatatca   4440

ctgacattcc catcattatg agtcgggaat tcatgataat gttcgatcca aacataaatc   4500

atatcagtaa acacattaaa gacaaatcca atcctgggat caaaattaat tggagtaaac   4560

aacagaaaag acttagaaaa tttcctaatc agttcaaacc atttatagat gtatttggct   4620

gtcagttacc tttgactgta gaagcacctt acagctataa tggaaccctt ttccgactgt   4680

cctttagaac tcaacaggaa gcaaaagtga gtgaagttag tagtacgtgc tacaatacag   4740

cagatattta ttctcttgtg gatgaattta gtctctgtgg acacaggctt atcattttca   4800

ctcagagtgt aaagtcaatg tatttgaagt acttgaaaat tgaggaaacc aaccccagtt   4860

tagcacaaga tacagtaata attaaaaaaa aatcctgctc ttccaaagca ttgaacacac   4920

ctgtcttaag tgttttaaaa gaggctgcta agctcatgaa gacttgcagc agcagtaata   4980

aaaagcttcc cagtgatgaa ccaaagtcat cttgcattct tcagatcaca gtggaagaat   5040

ttcaccatgt gttcagaagg attgctgatt tacagtcgcc actttttaga ggtccagatg   5100

atgacccagc tgctctcttt gaaatggcta agtctggcca atcaaaaaag ccatcagatg   5160

agttgtcaca gaaaacagta gagtgtacca cgtggcttct gtgtacttgc atggacacag   5220

gagaggctct gaagttttcc ctgagtgaga gtggaagaag actaggactg gttccatgtg   5280

gggcagtagg agttcagctg tcagaaatcc aggaccagaa gtggacagtg aaaccacaca   5340

ttggagaggt gttttgctat ttacctttac gaataaaaac aggcttgcca gttcatatca   5400

atgggtgctt tgctgttaca tcaaatagga aagaaatctg gaaaacagat acaaaaggac   5460

gatggaatac cacgttcatg agacatgtta ttgtgaaagc ttacttacag gtactgagtg   5520

tcttacggga cctggccact agtggggagc taatggatta tacttactat gcagtatggc   5580

ccgatcctga tttagttcat gatgattttt ctgtaatttg ccaaggattt tatgaagata   5640

tagctcatgg aaaagggaaa gaactgacca aagtcttctc tgatggatct acttgggttt   5700

ccatgaagaa cgtaagattt ctagatgact ctatacttaa aagaagagat gttggttcag   5760

cagccttcaa gatatttttg aaatacctca agaagactgg gtccaaaaac ctttgtgctg   5820

ttgaacttcc ttcttcggta aaattaggat ttgaagaagc tggctgcaaa cagatactac   5880

ttgaaaacac attttcagag aaacagtttt tttctgaagt gttttttcca aatattcaag   5940

aaattgaagc agaacttaga gatcctttaa tgatctttgt tctaaatgaa aaagttgatg   6000

agttctcggg agttcttcgt gttactccat gtattccttg ttccttggag gggcatcctt   6060

tggttttgcc atcaagattg atccaccccg aaggacgagt tgcaaagtta tttgatatta   6120

aagatgggag attcccttat ggttctactc aggattatct caatcctatt attttgatta   6180

aactagttca gttaggtatg gcaaaagatg atattttatg ggatgatatg ctagaacgtg   6240

cagtgtcagt agctgaaatt aataaaagtg atcatgttgc tgcatgccta agaagtagta   6300

tcttattgag tcttatcgat gagaaactaa aaataaggga tcctagagca aaggattttg   6360

ctgcaaaata tcaaacaatc cgcttccttc catttctgac aaaaccagca ggtttttctt   6420

tggactggaa aggcaacagt tttaagcctg aaaccatgtt tgcagcaact gacctttata   6480

cagctgaaca tcaagatata gtttgtcttt tgcaaccaat tctaaatgaa aattcccatt   6540

cttttagagg ttgtggttca gtgtcattgg ctgttaaaga gtttttggga ttactcaaga   6600

agccaacagt tgatctggtt ataaaccaat tgaaagaagt agcaaaatca gttgatgatg   6660

gaattacact gtaccaggag aatatcacca atgcttgcta caaatacctt catgaagcct   6720

tgatgcaaaa tgaaatcact aagatgtcaa ttattgataa gttaaaaccc tttagcttca   6780

ttctagttga gaatgcatat gttgactcag aaaaggtttc ttttcattta aattttgagg   6840

cggcaccata cctttatcag ttgcctaata agtataaaaa taatttccgc gaactttttg   6900

aaaccgtggg tgtgaggcag tcatgcactg ttgaagattt tgctcttgtt ttggaatcta   6960

ttgatcaaga aagaggaaca aagcaaataa cagaagagaa ttttcagctt tgccgacgaa   7020

taatcagtga aggaatatgg agtctcatta gagaaaagaa acaagaattt tgtgagaaaa   7080

attatggcaa gatattattg ccagatacta atcttatgct tctccctgct aaatcgttat   7140

gctacaatga ttgcccttgg ataaaagtaa aggataccac tgtaaaatat tgtcatgctg   7200

acatacccag ggaagtagca gtaaaactag gagcagtccc aaagcgacac aaagccttag   7260

aaagatatgc atccaatgtc tgttttacaa cacttggcac agaatttggg cagaaagaaa   7320

aattgaccag cagaattaag agcatcctta atgcatatcc ttctgaaaag gaaatgttga   7380

aagagcttct tcaaaatgct gatgatgcaa aggcgacaga aatctgtttt gtgtttgatc   7440

ctagacagca tccagttgat agaatatttg atgataagtg ggccccattg caagggccag   7500

cactttgtgt gtacaacaac cagccattta cagaagatga tgttagagga attcagaatc   7560

ttggaaaagg cacgaaagag ggaaatcctt ataaaactgg acagtatgga ataggattca   7620

attctgtgta tcatatcaca gactgcccat cttttatttc tggcaatgac atcctgtgta   7680

tttttgatcc tcatgccaga tatgcaccag gggccacatc cattagtccc ggacgcatgt   7740

ttagagattt ggatgcagat tttaggacac agttctcaga tgttctggat ctttatctgg   7800

gaacccattt taaactggat aattgcacaa tgttcagatt tcctcttcgt aatgcagaaa   7860

tggcaaaagt ttcggaaatt tcgtctgttc cagcatcaga cagaatggtc cagaatcttt   7920

tggacaaact gcgctcagat ggggcagaac ttctaatgtt tcttaatcac atggaaaaaa   7980

tttctatttg tgaaatagat aagagtactg gagctctaaa tgtgctgtat tcagtaaagg   8040

gcaaaatcac agatggagac agattgaaaa ggaaacaatt tcatgcatct gtaattgata   8100

gtgttactaa aaagaggcag ctcaaagaca taccagttca acaaataacc tatactatgg   8160

atactgagga ctctgaagga aatcttacta cg                                 8192


<210>  3073
<211>  4432
<212>  PRT
<213>  Homosapiens

<400>  3073

Met Ala Pro Tyr Gln Gly Pro Ala Leu Tyr Val Tyr Asn Asn Ala Val 
1               5                   10                  15      


Phe Thr Pro Glu Asp Trp His Gly Ile Gln Glu Ile Ala Arg Ser Arg 
            20                  25                  30          


Lys Lys Asp Asp Pro Leu Lys Val Gly Arg Phe Gly Ile Gly Phe Asn 
        35                  40                  45              


Ser Val Tyr His Ile Thr Asp Val Pro Cys Ile Phe Ser Gly Asp Gln 
    50                  55                  60                  


Ile Gly Met Leu Asp Pro His Gln Thr Leu Phe Gly Pro His Glu Ser 
65                  70                  75                  80  


Gly Gln Cys Trp Asn Leu Lys Asp Asp Ser Lys Glu Ile Ser Glu Leu 
                85                  90                  95      


Ser Asp Gln Phe Ala Pro Phe Val Gly Ile Phe Gly Ser Thr Lys Glu 
            100                 105                 110         


Thr Phe Ile Asn Gly Asn Phe Pro Gly Thr Phe Phe Arg Phe Pro Leu 
        115                 120                 125             


Arg Leu Gln Pro Ser Gln Leu Ser Ser Asn Leu Tyr Asn Lys Gln Lys 
    130                 135                 140                 


Val Leu Glu Leu Phe Glu Ser Phe Arg Ala Asp Ala Asp Thr Val Leu 
145                 150                 155                 160 


Leu Phe Leu Lys Ser Val Gln Asp Val Ser Leu Tyr Val Arg Glu Ala 
                165                 170                 175     


Asp Gly Thr Glu Lys Leu Val Phe Arg Val Thr Ser Ser Glu Ser Lys 
            180                 185                 190         


Ala Leu Lys His Glu Arg Pro Asn Ser Ile Lys Ile Leu Gly Thr Ala 
        195                 200                 205             


Ile Ser Asn Tyr Cys Lys Lys Thr Pro Ser Asn Asn Ile Thr Cys Val 
    210                 215                 220                 


Thr Tyr His Val Asn Ile Val Leu Glu Glu Glu Ser Thr Lys Asp Ala 
225                 230                 235                 240 


Gln Lys Thr Ser Trp Leu Val Cys Asn Ser Val Gly Gly Arg Gly Ile 
                245                 250                 255     


Ser Ser Lys Leu Asp Ser Leu Ala Asp Glu Leu Lys Phe Val Pro Ile 
            260                 265                 270         


Ile Gly Ile Ala Met Pro Leu Ser Ser Arg Asp Asp Glu Ala Lys Gly 
        275                 280                 285             


Ala Thr Ser Asp Phe Ser Gly Lys Ala Phe Cys Phe Leu Pro Leu Pro 
    290                 295                 300                 


Pro Gly Glu Glu Ser Ser Thr Gly Leu Pro Val His Ile Ser Gly Phe 
305                 310                 315                 320 


Phe Gly Leu Thr Asp Asn Arg Arg Ser Ile Lys Trp Arg Glu Leu Asp 
                325                 330                 335     


Gln Trp Arg Asp Pro Ala Ala Leu Trp Asn Glu Phe Leu Val Met Asn 
            340                 345                 350         


Val Val Pro Lys Ala Tyr Ala Thr Leu Ile Leu Asp Ser Ile Lys Arg 
        355                 360                 365             


Leu Glu Met Glu Lys Ser Ser Asp Phe Pro Leu Ser Val Asp Val Ile 
    370                 375                 380                 


Tyr Lys Leu Trp Pro Glu Ala Ser Lys Val Lys Val His Trp Gln Pro 
385                 390                 395                 400 


Val Leu Glu Pro Leu Phe Ser Glu Leu Leu Gln Asn Ala Val Ile Tyr 
                405                 410                 415     


Ser Ile Ser Cys Asp Trp Val Arg Leu Glu Gln Val Tyr Phe Ser Glu 
            420                 425                 430         


Leu Asp Glu Asn Leu Glu Tyr Thr Lys Thr Val Leu Asn Tyr Leu Gln 
        435                 440                 445             


Ser Ser Gly Lys Gln Ile Ala Lys Val Pro Gly Asn Val Asp Ala Ala 
    450                 455                 460                 


Val Gln Leu Thr Ala Ala Ser Gly Thr Thr Pro Val Arg Lys Val Thr 
465                 470                 475                 480 


Pro Ala Trp Val Arg Gln Val Leu Arg Lys Cys Ala His Leu Gly Cys 
                485                 490                 495     


Ala Glu Glu Lys Leu His Leu Leu Glu Phe Val Leu Ser Asp Gln Ala 
            500                 505                 510         


Tyr Ser Glu Leu Leu Gly Leu Glu Leu Leu Pro Leu Gln Asn Gly Asn 
        515                 520                 525             


Phe Val Pro Phe Ser Ser Ser Val Ser Asp Gln Asp Val Ile Tyr Ile 
    530                 535                 540                 


Thr Ser Ala Glu Tyr Pro Arg Ser Leu Phe Pro Ser Leu Glu Gly Arg 
545                 550                 555                 560 


Phe Ile Leu Asp Asn Leu Lys Pro His Leu Val Ala Ala Leu Lys Glu 
                565                 570                 575     


Ala Ala Gln Thr Arg Gly Arg Pro Cys Thr Gln Leu Gln Leu Leu Asn 
            580                 585                 590         


Pro Glu Arg Phe Ala Arg Leu Ile Lys Glu Val Met Asn Thr Phe Trp 
        595                 600                 605             


Pro Gly Arg Glu Leu Ile Val Gln Trp Tyr Pro Phe Asp Glu Asn Arg 
    610                 615                 620                 


Asn His Pro Ser Val Ser Trp Leu Lys Met Val Trp Lys Asn Leu Tyr 
625                 630                 635                 640 


Ile His Phe Ser Glu Asp Leu Thr Leu Phe Asp Glu Met Pro Leu Ile 
                645                 650                 655     


Pro Arg Thr Ile Leu Glu Glu Gly Gln Thr Cys Val Glu Leu Ile Arg 
            660                 665                 670         


Leu Arg Ile Pro Ser Leu Val Ile Leu Asp Asp Glu Ser Glu Ala Gln 
        675                 680                 685             


Leu Pro Glu Phe Leu Ala Asp Ile Val Gln Lys Leu Gly Gly Phe Val 
    690                 695                 700                 


Leu Lys Lys Leu Asp Ala Ser Ile Gln His Pro Leu Ile Lys Lys Tyr 
705                 710                 715                 720 


Ile His Ser Pro Leu Pro Ser Ala Val Leu Gln Ile Met Glu Lys Met 
                725                 730                 735     


Pro Leu Gln Lys Leu Cys Asn Gln Ile Thr Ser Leu Leu Pro Thr His 
            740                 745                 750         


Lys Asp Ala Leu Arg Lys Phe Leu Ala Ser Leu Thr Asp Ser Ser Glu 
        755                 760                 765             


Lys Glu Lys Arg Ile Ile Gln Glu Leu Ala Ile Phe Lys Arg Ile Asn 
    770                 775                 780                 


His Ser Ser Asp Gln Gly Ile Ser Ser Tyr Thr Lys Leu Lys Gly Cys 
785                 790                 795                 800 


Lys Val Leu His His Thr Ala Lys Leu Pro Ala Asp Leu Arg Leu Ser 
                805                 810                 815     


Ile Ser Val Ile Asp Ser Ser Asp Glu Ala Thr Ile Arg Leu Ala Asn 
            820                 825                 830         


Met Leu Lys Ile Glu Gln Leu Lys Thr Thr Ser Cys Leu Lys Leu Val 
        835                 840                 845             


Leu Lys Asp Ile Glu Asn Ala Phe Tyr Ser His Glu Glu Val Thr Gln 
    850                 855                 860                 


Leu Met Leu Trp Val Leu Glu Asn Leu Ser Ser Leu Lys Asn Glu Asn 
865                 870                 875                 880 


Pro Asn Val Leu Glu Trp Leu Thr Pro Leu Lys Phe Ile Gln Ile Ser 
                885                 890                 895     


Gln Glu Gln Met Val Ser Ala Gly Glu Leu Phe Asp Pro Asp Ile Glu 
            900                 905                 910         


Val Leu Lys Asp Leu Phe Cys Asn Glu Glu Gly Thr Tyr Phe Pro Pro 
        915                 920                 925             


Ser Val Phe Thr Ser Pro Asp Ile Leu His Ser Leu Arg Gln Ile Gly 
    930                 935                 940                 


Leu Lys Asn Glu Ala Ser Leu Lys Glu Lys Asp Val Val Gln Val Ala 
945                 950                 955                 960 


Lys Lys Ile Glu Ala Leu Gln Val Gly Ala Cys Pro Asp Gln Asp Val 
                965                 970                 975     


Leu Leu Lys Lys Ala Lys Thr Leu Leu Leu Val Leu Asn Lys Asn His 
            980                 985                 990         


Thr Leu Leu Gln Ser Ser Glu Gly  Lys Met Thr Leu Lys  Lys Ile Lys 
        995                 1000                 1005             


Trp Val  Pro Ala Cys Lys Glu  Arg Pro Pro Asn Tyr  Pro Gly Ser 
    1010                 1015                 1020             


Leu Val  Trp Lys Gly Asp Leu  Cys Asn Leu Cys Ala  Pro Pro Asp 
    1025                 1030                 1035             


Met Cys  Asp Val Gly His Ala  Ile Leu Ile Gly Ser  Ser Leu Pro 
    1040                 1045                 1050             


Leu Val  Glu Ser Ile His Val  Asn Leu Glu Lys Ala  Leu Gly Ile 
    1055                 1060                 1065             


Phe Thr  Lys Pro Ser Leu Ser  Ala Val Leu Lys His  Phe Lys Ile 
    1070                 1075                 1080             


Val Val  Asp Trp Tyr Ser Ser  Lys Thr Phe Ser Asp  Glu Asp Tyr 
    1085                 1090                 1095             


Tyr Gln  Phe Gln His Ile Leu  Leu Glu Ile Tyr Gly  Phe Met His 
    1100                 1105                 1110             


Asp His  Leu Asn Glu Gly Lys  Asp Ser Phe Arg Ala  Leu Lys Phe 
    1115                 1120                 1125             


Pro Trp  Val Trp Thr Gly Lys  Lys Phe Cys Pro Leu  Ala Gln Ala 
    1130                 1135                 1140             


Val Ile  Lys Pro Ile His Asp  Leu Asp Leu Gln Pro  Tyr Leu His 
    1145                 1150                 1155             


Asn Val  Pro Lys Thr Met Ala  Lys Phe His Gln Leu  Phe Lys Val 
    1160                 1165                 1170             


Cys Gly  Ser Ile Glu Glu Leu  Thr Ser Asp His Ile  Ser Met Val 
    1175                 1180                 1185             


Ile Gln  Lys Ile Tyr Leu Lys  Ser Asp Gln Asp Leu  Ser Glu Gln 
    1190                 1195                 1200             


Glu Ser  Lys Gln Asn Leu His  Leu Met Leu Asn Ile  Ile Arg Trp 
    1205                 1210                 1215             


Leu Tyr  Ser Asn Gln Ile Pro  Ala Ser Pro Asn Thr  Pro Val Pro 
    1220                 1225                 1230             


Ile His  His Ser Lys Asn Pro  Ser Lys Leu Ile Met  Lys Pro Ile 
    1235                 1240                 1245             


His Glu  Cys Cys Tyr Cys Asp  Ile Lys Val Asp Asp  Leu Asn Asp 
    1250                 1255                 1260             


Leu Leu  Glu Asp Ser Val Glu  Pro Ile Ile Leu Val  His Glu Asp 
    1265                 1270                 1275             


Ile Pro  Met Lys Thr Ala Glu  Trp Leu Lys Val Pro  Cys Leu Ser 
    1280                 1285                 1290             


Thr Arg  Leu Ile Asn Pro Glu  Asn Met Gly Phe Glu  Gln Ser Gly 
    1295                 1300                 1305             


Gln Arg  Glu Pro Leu Thr Val  Arg Ile Lys Asn Ile  Leu Glu Glu 
    1310                 1315                 1320             


Tyr Pro  Ser Val Ser Asp Ile  Phe Lys Glu Leu Leu  Gln Asn Ala 
    1325                 1330                 1335             


Asp Asp  Ala Asn Ala Thr Glu  Cys Ser Phe Leu Ile  Asp Met Arg 
    1340                 1345                 1350             


Arg Asn  Met Asp Ile Arg Glu  Asn Leu Leu Asp Pro  Gly Met Ala 
    1355                 1360                 1365             


Ala Cys  His Gly Pro Ala Leu  Trp Ser Phe Asn Asn  Ser Gln Phe 
    1370                 1375                 1380             


Ser Asp  Ser Asp Phe Val Asn  Ile Thr Arg Leu Gly  Glu Ser Leu 
    1385                 1390                 1395             


Lys Arg  Gly Glu Val Asp Lys  Val Gly Lys Phe Gly  Leu Gly Phe 
    1400                 1405                 1410             


Asn Ser  Val Tyr His Ile Thr  Asp Ile Pro Ile Ile  Met Ser Arg 
    1415                 1420                 1425             


Glu Phe  Met Ile Met Phe Asp  Pro Asn Ile Asn His  Ile Ser Lys 
    1430                 1435                 1440             


His Ile  Lys Asp Lys Ser Asn  Pro Gly Ile Lys Ile  Asn Trp Ser 
    1445                 1450                 1455             


Lys Gln  Gln Lys Arg Leu Arg  Lys Phe Pro Asn Gln  Phe Lys Pro 
    1460                 1465                 1470             


Phe Ile  Asp Val Phe Gly Cys  Gln Leu Pro Leu Thr  Val Glu Ala 
    1475                 1480                 1485             


Pro Tyr  Ser Tyr Asn Gly Thr  Leu Phe Arg Leu Ser  Phe Arg Thr 
    1490                 1495                 1500             


Gln Gln  Glu Ala Lys Val Ser  Glu Val Ser Ser Thr  Cys Tyr Asn 
    1505                 1510                 1515             


Thr Ala  Asp Ile Tyr Ser Leu  Val Asp Glu Phe Ser  Leu Cys Gly 
    1520                 1525                 1530             


His Arg  Leu Ile Ile Phe Thr  Gln Ser Val Lys Ser  Met Tyr Leu 
    1535                 1540                 1545             


Lys Tyr  Leu Lys Ile Glu Glu  Thr Asn Pro Ser Leu  Ala Gln Asp 
    1550                 1555                 1560             


Thr Val  Ile Ile Lys Lys Lys  Ser Cys Ser Ser Lys  Ala Leu Asn 
    1565                 1570                 1575             


Thr Pro  Val Leu Ser Val Leu  Lys Glu Ala Ala Lys  Leu Met Lys 
    1580                 1585                 1590             


Thr Cys  Ser Ser Ser Asn Lys  Lys Leu Pro Ser Asp  Glu Pro Lys 
    1595                 1600                 1605             


Ser Ser  Cys Ile Leu Gln Ile  Thr Val Glu Glu Phe  His His Val 
    1610                 1615                 1620             


Phe Arg  Arg Ile Ala Asp Leu  Gln Ser Pro Leu Phe  Arg Gly Pro 
    1625                 1630                 1635             


Asp Asp  Asp Pro Ala Ala Leu  Phe Glu Met Ala Lys  Ser Gly Gln 
    1640                 1645                 1650             


Ser Lys  Lys Pro Ser Asp Glu  Leu Ser Gln Lys Thr  Val Glu Cys 
    1655                 1660                 1665             


Thr Thr  Trp Leu Leu Cys Thr  Cys Met Asp Thr Gly  Glu Ala Leu 
    1670                 1675                 1680             


Lys Phe  Ser Leu Ser Glu Ser  Gly Arg Arg Leu Gly  Leu Val Pro 
    1685                 1690                 1695             


Cys Gly  Ala Val Gly Val Gln  Leu Ser Glu Ile Gln  Asp Gln Lys 
    1700                 1705                 1710             


Trp Thr  Val Lys Pro His Ile  Gly Glu Val Phe Cys  Tyr Leu Pro 
    1715                 1720                 1725             


Leu Arg  Ile Lys Thr Gly Leu  Pro Val His Ile Asn  Gly Cys Phe 
    1730                 1735                 1740             


Ala Val  Thr Ser Asn Arg Lys  Glu Ile Trp Lys Thr  Asp Thr Lys 
    1745                 1750                 1755             


Gly Arg  Trp Asn Thr Thr Phe  Met Arg His Val Ile  Val Lys Ala 
    1760                 1765                 1770             


Tyr Leu  Gln Val Leu Ser Val  Leu Arg Asp Leu Ala  Thr Ser Gly 
    1775                 1780                 1785             


Glu Leu  Met Asp Tyr Thr Tyr  Tyr Ala Val Trp Pro  Asp Pro Asp 
    1790                 1795                 1800             


Leu Val  His Asp Asp Phe Ser  Val Ile Cys Gln Gly  Phe Tyr Glu 
    1805                 1810                 1815             


Asp Ile  Ala His Gly Lys Gly  Lys Glu Leu Thr Lys  Val Phe Ser 
    1820                 1825                 1830             


Asp Gly  Ser Thr Trp Val Ser  Met Lys Asn Val Arg  Phe Leu Asp 
    1835                 1840                 1845             


Asp Ser  Ile Leu Lys Arg Arg  Asp Val Gly Ser Ala  Ala Phe Lys 
    1850                 1855                 1860             


Ile Phe  Leu Lys Tyr Leu Lys  Lys Thr Gly Ser Lys  Asn Leu Cys 
    1865                 1870                 1875             


Ala Val  Glu Leu Pro Ser Ser  Val Lys Leu Gly Phe  Glu Glu Ala 
    1880                 1885                 1890             


Gly Cys  Lys Gln Ile Leu Leu  Glu Asn Thr Phe Ser  Glu Lys Gln 
    1895                 1900                 1905             


Phe Phe  Ser Glu Val Phe Phe  Pro Asn Ile Gln Glu  Ile Glu Ala 
    1910                 1915                 1920             


Glu Leu  Arg Asp Pro Leu Met  Ile Phe Val Leu Asn  Glu Lys Val 
    1925                 1930                 1935             


Asp Glu  Phe Ser Gly Val Leu  Arg Val Thr Pro Cys  Ile Pro Cys 
    1940                 1945                 1950             


Ser Leu  Glu Gly His Pro Leu  Val Leu Pro Ser Arg  Leu Ile His 
    1955                 1960                 1965             


Pro Glu  Gly Arg Val Ala Lys  Leu Phe Asp Ile Lys  Asp Gly Arg 
    1970                 1975                 1980             


Phe Pro  Tyr Gly Ser Thr Gln  Asp Tyr Leu Asn Pro  Ile Ile Leu 
    1985                 1990                 1995             


Ile Lys  Leu Val Gln Leu Gly  Met Ala Lys Asp Asp  Ile Leu Trp 
    2000                 2005                 2010             


Asp Asp  Met Leu Glu Arg Ala  Val Ser Val Ala Glu  Ile Asn Lys 
    2015                 2020                 2025             


Ser Asp  His Val Ala Ala Cys  Leu Arg Ser Ser Ile  Leu Leu Ser 
    2030                 2035                 2040             


Leu Ile  Asp Glu Lys Leu Lys  Ile Arg Asp Pro Arg  Ala Lys Asp 
    2045                 2050                 2055             


Phe Ala  Ala Lys Tyr Gln Thr  Ile Arg Phe Leu Pro  Phe Leu Thr 
    2060                 2065                 2070             


Lys Pro  Ala Gly Phe Ser Leu  Asp Trp Lys Gly Asn  Ser Phe Lys 
    2075                 2080                 2085             


Pro Glu  Thr Met Phe Ala Ala  Thr Asp Leu Tyr Thr  Ala Glu His 
    2090                 2095                 2100             


Gln Asp  Ile Val Cys Leu Leu  Gln Pro Ile Leu Asn  Glu Asn Ser 
    2105                 2110                 2115             


His Ser  Phe Arg Gly Cys Gly  Ser Val Ser Leu Ala  Val Lys Glu 
    2120                 2125                 2130             


Phe Leu  Gly Leu Leu Lys Lys  Pro Thr Val Asp Leu  Val Ile Asn 
    2135                 2140                 2145             


Gln Leu  Lys Glu Val Ala Lys  Ser Val Asp Asp Gly  Ile Thr Leu 
    2150                 2155                 2160             


Tyr Gln  Glu Asn Ile Thr Asn  Ala Cys Tyr Lys Tyr  Leu His Glu 
    2165                 2170                 2175             


Ala Leu  Met Gln Asn Glu Ile  Thr Lys Met Ser Ile  Ile Asp Lys 
    2180                 2185                 2190             


Leu Lys  Pro Phe Ser Phe Ile  Leu Val Glu Asn Ala  Tyr Val Asp 
    2195                 2200                 2205             


Ser Glu  Lys Val Ser Phe His  Leu Asn Phe Glu Ala  Ala Pro Tyr 
    2210                 2215                 2220             


Leu Tyr  Gln Leu Pro Asn Lys  Tyr Lys Asn Asn Phe  Arg Glu Leu 
    2225                 2230                 2235             


Phe Glu  Thr Val Gly Val Arg  Gln Ser Cys Thr Val  Glu Asp Phe 
    2240                 2245                 2250             


Ala Leu  Val Leu Glu Ser Ile  Asp Gln Glu Arg Gly  Thr Lys Gln 
    2255                 2260                 2265             


Ile Thr  Glu Glu Asn Phe Gln  Leu Cys Arg Arg Ile  Ile Ser Glu 
    2270                 2275                 2280             


Gly Ile  Trp Ser Leu Ile Arg  Glu Lys Lys Gln Glu  Phe Cys Glu 
    2285                 2290                 2295             


Lys Asn  Tyr Gly Lys Ile Leu  Leu Pro Asp Thr Asn  Leu Met Leu 
    2300                 2305                 2310             


Leu Pro  Ala Lys Ser Leu Cys  Tyr Asn Asp Cys Pro  Trp Ile Lys 
    2315                 2320                 2325             


Val Lys  Asp Thr Thr Val Lys  Tyr Cys His Ala Asp  Ile Pro Arg 
    2330                 2335                 2340             


Glu Val  Ala Val Lys Leu Gly  Ala Val Pro Lys Arg  His Lys Ala 
    2345                 2350                 2355             


Leu Glu  Arg Tyr Ala Ser Asn  Val Cys Phe Thr Thr  Leu Gly Thr 
    2360                 2365                 2370             


Glu Phe  Gly Gln Lys Glu Lys  Leu Thr Ser Arg Ile  Lys Ser Ile 
    2375                 2380                 2385             


Leu Asn  Ala Tyr Pro Ser Glu  Lys Glu Met Leu Lys  Glu Leu Leu 
    2390                 2395                 2400             


Gln Asn  Ala Asp Asp Ala Lys  Ala Thr Glu Ile Cys  Phe Val Phe 
    2405                 2410                 2415             


Asp Pro  Arg Gln His Pro Val  Asp Arg Ile Phe Asp  Asp Lys Trp 
    2420                 2425                 2430             


Ala Pro  Leu Gln Gly Pro Ala  Leu Cys Val Tyr Asn  Asn Gln Pro 
    2435                 2440                 2445             


Phe Thr  Glu Asp Asp Val Arg  Gly Ile Gln Asn Leu  Gly Lys Gly 
    2450                 2455                 2460             


Thr Lys  Glu Gly Asn Pro Tyr  Lys Thr Gly Gln Tyr  Gly Ile Gly 
    2465                 2470                 2475             


Phe Asn  Ser Val Tyr His Ile  Thr Asp Cys Pro Ser  Phe Ile Ser 
    2480                 2485                 2490             


Gly Asn  Asp Ile Leu Cys Ile  Phe Asp Pro His Ala  Arg Tyr Ala 
    2495                 2500                 2505             


Pro Gly  Ala Thr Ser Ile Ser  Pro Gly Arg Met Phe  Arg Asp Leu 
    2510                 2515                 2520             


Asp Ala  Asp Phe Arg Thr Gln  Phe Ser Asp Val Leu  Asp Leu Tyr 
    2525                 2530                 2535             


Leu Gly  Thr His Phe Lys Leu  Asp Asn Cys Thr Met  Phe Arg Phe 
    2540                 2545                 2550             


Pro Leu  Arg Asn Ala Glu Met  Ala Lys Val Ser Glu  Ile Ser Ser 
    2555                 2560                 2565             


Val Pro  Ala Ser Asp Arg Met  Val Gln Asn Leu Leu  Asp Lys Leu 
    2570                 2575                 2580             


Arg Ser  Asp Gly Ala Glu Leu  Leu Met Phe Leu Asn  His Met Glu 
    2585                 2590                 2595             


Lys Ile  Ser Ile Cys Glu Ile  Asp Lys Ser Thr Gly  Ala Leu Asn 
    2600                 2605                 2610             


Val Leu  Tyr Ser Val Lys Gly  Lys Ile Thr Asp Gly  Asp Arg Leu 
    2615                 2620                 2625             


Lys Arg  Lys Gln Phe His Ala  Ser Val Ile Asp Ser  Val Thr Lys 
    2630                 2635                 2640             


Lys Arg  Gln Leu Lys Asp Ile  Pro Val Gln Gln Ile  Thr Tyr Thr 
    2645                 2650                 2655             


Met Asp  Thr Glu Asp Ser Glu  Gly Asn Leu Thr Thr  Trp Leu Ile 
    2660                 2665                 2670             


Cys Asn  Arg Ser Gly Phe Ser  Ser Met Glu Lys Val  Ser Lys Ser 
    2675                 2680                 2685             


Val Ile  Ser Ala His Lys Asn  Gln Asp Ile Thr Leu  Phe Pro Arg 
    2690                 2695                 2700             


Gly Gly  Val Ala Ala Cys Ile  Thr His Asn Tyr Lys  Lys Pro His 
    2705                 2710                 2715             


Arg Ala  Phe Cys Phe Leu Pro  Leu Ser Leu Glu Thr  Gly Leu Pro 
    2720                 2725                 2730             


Phe His  Val Asn Gly His Phe  Ala Leu Asp Ser Ala  Arg Arg Asn 
    2735                 2740                 2745             


Leu Trp  Arg Asp Asp Asn Gly  Val Gly Val Arg Ser  Asp Trp Asn 
    2750                 2755                 2760             


Asn Ser  Leu Met Thr Ala Leu  Ile Ala Pro Ala Tyr  Val Glu Leu 
    2765                 2770                 2775             


Leu Ile  Gln Leu Lys Lys Arg  Tyr Phe Pro Gly Ser  Asp Pro Thr 
    2780                 2785                 2790             


Leu Ser  Val Leu Gln Asn Thr  Pro Ile His Val Val  Lys Asp Thr 
    2795                 2800                 2805             


Leu Lys  Lys Phe Leu Ser Phe  Phe Pro Val Asn Arg  Leu Asp Leu 
    2810                 2815                 2820             


Gln Pro  Asp Leu Tyr Cys Leu  Val Lys Ala Leu Tyr  Asn Cys Ile 
    2825                 2830                 2835             


His Glu  Asp Met Lys Arg Leu  Leu Pro Val Val Arg  Ala Pro Asn 
    2840                 2845                 2850             


Ile Asp  Gly Ser Asp Leu His  Ser Ala Val Ile Ile  Thr Trp Ile 
    2855                 2860                 2865             


Asn Met  Ser Thr Ser Asn Lys  Thr Arg Pro Phe Phe  Asp Asn Leu 
    2870                 2875                 2880             


Leu Gln  Asp Glu Leu Gln His  Leu Lys Asn Ala Asp  Tyr Asn Ile 
    2885                 2890                 2895             


Thr Thr  Arg Lys Thr Val Ala  Glu Asn Val Tyr Arg  Leu Lys His 
    2900                 2905                 2910             


Leu Leu  Leu Glu Ile Gly Phe  Asn Leu Val Tyr Asn  Cys Asp Glu 
    2915                 2920                 2925             


Thr Ala  Asn Leu Tyr His Cys  Leu Ile Asp Ala Asp  Ile Pro Val 
    2930                 2935                 2940             


Ser Tyr  Val Thr Pro Ala Asp  Ile Arg Ser Phe Leu  Met Thr Phe 
    2945                 2950                 2955             


Ser Ser  Pro Asp Thr Asn Cys  His Ile Gly Lys Leu  Pro Cys Arg 
    2960                 2965                 2970             


Leu Gln  Gln Thr Asn Leu Lys  Leu Phe His Ser Leu  Lys Leu Leu 
    2975                 2980                 2985             


Val Asp  Tyr Cys Phe Lys Asp  Ala Glu Glu Asn Glu  Ile Glu Val 
    2990                 2995                 3000             


Glu Gly  Leu Pro Leu Leu Ile  Thr Leu Asp Ser Val  Leu Gln Thr 
    3005                 3010                 3015             


Phe Asp  Ala Lys Arg Pro Lys  Phe Leu Thr Thr Tyr  His Glu Leu 
    3020                 3025                 3030             


Ile Pro  Ser Arg Lys Asp Leu  Phe Met Asn Thr Leu  Tyr Leu Lys 
    3035                 3040                 3045             


Tyr Ser  Asn Ile Leu Leu Asn  Cys Lys Val Ala Lys  Val Phe Asp 
    3050                 3055                 3060             


Ile Ser  Ser Phe Ala Asp Leu  Leu Ser Ser Val Leu  Pro Arg Glu 
    3065                 3070                 3075             


Tyr Lys  Thr Lys Ser Cys Thr  Lys Trp Lys Asp Asn  Phe Ala Ser 
    3080                 3085                 3090             


Glu Ser  Trp Leu Lys Asn Ala  Trp His Phe Ile Ser  Glu Ser Val 
    3095                 3100                 3105             


Ser Val  Lys Glu Asp Gln Glu  Glu Thr Lys Pro Thr  Phe Asp Ile 
    3110                 3115                 3120             


Val Val  Asp Thr Leu Lys Asp  Trp Ala Leu Leu Pro  Gly Thr Lys 
    3125                 3130                 3135             


Phe Thr  Val Ser Ala Asn Gln  Leu Val Val Pro Glu  Gly Asp Val 
    3140                 3145                 3150             


Leu Leu  Pro Leu Ser Leu Met  His Ile Ala Val Phe  Pro Asn Ala 
    3155                 3160                 3165             


Gln Ser  Asp Lys Val Phe His  Ala Leu Met Lys Ala  Gly Cys Ile 
    3170                 3175                 3180             


Gln Leu  Ala Leu Asn Lys Ile  Cys Ser Lys Asp Ser  Ala Phe Val 
    3185                 3190                 3195             


Pro Leu  Leu Ser Cys His Thr  Ala Asn Ile Glu Ser  Pro Thr Ser 
    3200                 3205                 3210             


Ile Leu  Lys Ala Leu His Tyr  Met Val Gln Thr Ser  Thr Phe Arg 
    3215                 3220                 3225             


Ala Glu  Lys Leu Val Glu Asn  Asp Phe Glu Ala Leu  Leu Met Tyr 
    3230                 3235                 3240             


Phe Asn  Cys Asn Leu Asn His  Leu Met Ser Gln Asp  Asp Ile Lys 
    3245                 3250                 3255             


Ile Leu  Lys Ser Leu Pro Cys  Tyr Lys Ser Ile Ser  Gly Arg Tyr 
    3260                 3265                 3270             


Val Ser  Ile Gly Lys Phe Gly  Thr Cys Tyr Val Leu  Thr Lys Ser 
    3275                 3280                 3285             


Ile Pro  Ser Ala Glu Val Glu  Lys Trp Thr Gln Ser  Ser Ser Ser 
    3290                 3295                 3300             


Ala Phe  Leu Glu Glu Lys Ile  His Leu Lys Glu Leu  Tyr Glu Val 
    3305                 3310                 3315             


Ile Gly  Cys Val Pro Val Asp  Asp Leu Glu Val Tyr  Leu Lys His 
    3320                 3325                 3330             


Leu Leu  Pro Lys Ile Glu Asn  Leu Ser Tyr Asp Ala  Lys Leu Glu 
    3335                 3340                 3345             


His Leu  Ile Tyr Leu Lys Asn  Arg Leu Ser Ser Ala  Glu Glu Leu 
    3350                 3355                 3360             


Ser Glu  Ile Lys Glu Gln Leu  Phe Glu Lys Leu Glu  Ser Leu Leu 
    3365                 3370                 3375             


Ile Ile  His Asp Ala Asn Ser  Arg Leu Lys Gln Ala  Lys His Phe 
    3380                 3385                 3390             


Tyr Asp  Arg Thr Val Arg Val  Phe Glu Val Met Leu  Pro Glu Lys 
    3395                 3400                 3405             


Leu Phe  Ile Pro Asn Asp Phe  Phe Lys Lys Leu Glu  Gln Leu Ile 
    3410                 3415                 3420             


Lys Pro  Lys Asn His Val Thr  Phe Met Thr Ser Trp  Val Glu Phe 
    3425                 3430                 3435             


Leu Arg  Asn Ile Gly Leu Lys  Tyr Ile Leu Ser Gln  Gln Gln Leu 
    3440                 3445                 3450             


Leu Gln  Phe Ala Lys Glu Ile  Ser Val Arg Ala Asn  Thr Glu Asn 
    3455                 3460                 3465             


Trp Ser  Lys Glu Thr Leu Gln  Asn Thr Val Asp Ile  Leu Leu His 
    3470                 3475                 3480             


His Ile  Phe Gln Glu Arg Met  Asp Leu Leu Ser Gly  Asn Phe Leu 
    3485                 3490                 3495             


Lys Glu  Leu Ser Leu Ile Pro  Phe Leu Cys Pro Glu  Arg Ala Pro 
    3500                 3505                 3510             


Ala Glu  Phe Ile Arg Phe His  Pro Gln Tyr Gln Glu  Val Asn Gly 
    3515                 3520                 3525             


Thr Leu  Pro Leu Ile Lys Phe  Asn Gly Ala Gln Val  Asn Pro Lys 
    3530                 3535                 3540             


Phe Lys  Gln Cys Asp Val Leu  Gln Leu Leu Trp Thr  Ser Cys Pro 
    3545                 3550                 3555             


Ile Leu  Pro Glu Lys Ala Thr  Pro Leu Ser Ile Lys  Glu Gln Glu 
    3560                 3565                 3570             


Gly Ser  Asp Leu Gly Pro Gln  Glu Gln Leu Glu Gln  Val Leu Asn 
    3575                 3580                 3585             


Met Leu  Asn Val Asn Leu Asp  Pro Pro Leu Asp Lys  Val Ile Asn 
    3590                 3595                 3600             


Asn Cys  Arg Asn Ile Cys Asn  Ile Thr Thr Leu Asp  Glu Glu Met 
    3605                 3610                 3615             


Val Lys  Thr Arg Ala Lys Val  Leu Arg Ser Ile Tyr  Glu Phe Leu 
    3620                 3625                 3630             


Ser Ala  Glu Lys Arg Glu Phe  Arg Phe Gln Leu Arg  Gly Val Ala 
    3635                 3640                 3645             


Phe Val  Met Val Glu Asp Gly  Trp Lys Leu Leu Lys  Pro Glu Glu 
    3650                 3655                 3660             


Val Val  Ile Asn Leu Glu Tyr  Glu Ser Asp Phe Lys  Pro Tyr Leu 
    3665                 3670                 3675             


Tyr Lys  Leu Pro Leu Glu Leu  Gly Thr Phe His Gln  Leu Phe Lys 
    3680                 3685                 3690             


His Leu  Gly Thr Glu Asp Ile  Ile Ser Thr Lys Gln  Tyr Val Glu 
    3695                 3700                 3705             


Val Leu  Ser Arg Ile Phe Lys  Asn Ser Glu Gly Lys  Gln Leu Asp 
    3710                 3715                 3720             


Pro Asn  Glu Met Arg Thr Val  Lys Arg Val Val Ser  Gly Leu Phe 
    3725                 3730                 3735             


Arg Ser  Leu Gln Asn Asp Ser  Val Lys Val Arg Ser  Asp Leu Glu 
    3740                 3745                 3750             


Asn Val  Arg Asp Leu Ala Leu  Tyr Leu Pro Ser Gln  Asp Gly Arg 
    3755                 3760                 3765             


Leu Val  Lys Ser Ser Ile Leu  Val Phe Asp Asp Ala  Pro His Tyr 
    3770                 3775                 3780             


Lys Ser  Arg Ile Gln Gly Asn  Ile Gly Val Gln Met  Leu Val Asp 
    3785                 3790                 3795             


Leu Ser  Gln Cys Tyr Leu Gly  Lys Asp His Gly Phe  His Thr Lys 
    3800                 3805                 3810             


Leu Ile  Met Leu Phe Pro Gln  Lys Leu Arg Pro Arg  Leu Leu Ser 
    3815                 3820                 3825             


Ser Ile  Leu Glu Glu Gln Leu  Asp Glu Glu Thr Pro  Lys Val Cys 
    3830                 3835                 3840             


Gln Phe  Gly Ala Leu Cys Ser  Leu Gln Gly Arg Leu  Gln Leu Leu 
    3845                 3850                 3855             


Leu Ser  Ser Glu Gln Phe Ile  Thr Gly Leu Ile Arg  Ile Met Lys 
    3860                 3865                 3870             


His Glu  Asn Asp Asn Ala Phe  Leu Ala Asn Glu Glu  Lys Ala Ile 
    3875                 3880                 3885             


Arg Leu  Cys Lys Ala Leu Arg  Glu Gly Leu Lys Val  Ser Cys Phe 
    3890                 3895                 3900             


Glu Lys  Leu Gln Thr Thr Leu  Arg Val Lys Gly Phe  Asn Pro Ile 
    3905                 3910                 3915             


Pro His  Ser Arg Ser Glu Thr  Phe Ala Phe Leu Lys  Arg Phe Gly 
    3920                 3925                 3930             


Asn Ala  Val Ile Leu Leu Tyr  Ile Gln His Ser Asp  Ser Lys Asp 
    3935                 3940                 3945             


Ile Asn  Phe Leu Leu Ala Leu  Ala Met Thr Leu Lys  Ser Ala Thr 
    3950                 3955                 3960             


Asp Asn  Leu Ile Ser Asp Thr  Ser Tyr Leu Ile Ala  Met Leu Gly 
    3965                 3970                 3975             


Cys Asn  Asp Ile Tyr Arg Ile  Gly Glu Lys Leu Asp  Ser Leu Gly 
    3980                 3985                 3990             


Val Lys  Tyr Asp Ser Ser Glu  Pro Ser Lys Leu Glu  Leu Pro Met 
    3995                 4000                 4005             


Pro Gly  Thr Pro Ile Pro Ala  Glu Ile His Tyr Thr  Leu Leu Met 
    4010                 4015                 4020             


Asp Pro  Met Asn Val Phe Tyr  Pro Gly Glu Tyr Val  Gly Tyr Leu 
    4025                 4030                 4035             


Val Asp  Ala Glu Gly Gly Asp  Ile Tyr Gly Ser Tyr  Gln Pro Thr 
    4040                 4045                 4050             


Tyr Thr  Tyr Ala Ile Ile Val  Gln Glu Val Glu Arg  Glu Asp Ala 
    4055                 4060                 4065             


Asp Asn  Ser Ser Phe Leu Gly  Lys Ile Tyr Gln Ile  Asp Ile Gly 
    4070                 4075                 4080             


Tyr Ser  Glu Tyr Lys Ile Val  Ser Ser Leu Asp Leu  Tyr Lys Phe 
    4085                 4090                 4095             


Ser Arg  Pro Glu Glu Ser Ser  Gln Ser Arg Asp Ser  Ala Pro Ser 
    4100                 4105                 4110             


Thr Pro  Thr Ser Pro Thr Glu  Phe Leu Thr Pro Gly  Leu Arg Ser 
    4115                 4120                 4125             


Ile Pro  Pro Leu Phe Ser Gly  Arg Glu Ser His Lys  Thr Ser Ser 
    4130                 4135                 4140             


Lys His  Gln Ser Pro Lys Lys  Leu Lys Val Asn Ser  Leu Pro Glu 
    4145                 4150                 4155             


Ile Leu  Lys Glu Val Thr Ser  Val Val Glu Gln Ala  Trp Lys Leu 
    4160                 4165                 4170             


Pro Glu  Ser Glu Arg Lys Lys  Ile Ile Arg Arg Leu  Tyr Leu Lys 
    4175                 4180                 4185             


Trp His  Pro Asp Lys Asn Pro  Glu Asn His Asp Ile  Ala Asn Glu 
    4190                 4195                 4200             


Val Phe  Lys His Leu Gln Asn  Glu Ile Asn Arg Leu  Glu Lys Gln 
    4205                 4210                 4215             


Ala Phe  Leu Asp Gln Asn Ala  Asp Arg Ala Ser Arg  Arg Thr Phe 
    4220                 4225                 4230             


Ser Thr  Ser Ala Ser Arg Phe  Gln Ser Asp Lys Tyr  Ser Phe Gln 
    4235                 4240                 4245             


Arg Phe  Tyr Thr Ser Trp Asn  Gln Glu Ala Thr Ser  His Lys Ser 
    4250                 4255                 4260             


Glu Arg  Gln Gln Gln Asn Lys  Glu Lys Cys Pro Pro  Ser Ala Gly 
    4265                 4270                 4275             


Gln Thr  Tyr Ser Gln Arg Phe  Phe Val Pro Pro Thr  Phe Lys Ser 
    4280                 4285                 4290             


Val Gly  Asn Pro Val Glu Ala  Arg Arg Trp Leu Arg  Gln Ala Arg 
    4295                 4300                 4305             


Ala Asn  Phe Ser Ala Ala Arg  Asn Asp Leu His Lys  Asn Ala Asn 
    4310                 4315                 4320             


Glu Trp  Val Cys Phe Lys Cys  Tyr Leu Ser Thr Lys  Leu Ala Leu 
    4325                 4330                 4335             


Ile Ala  Ala Asp Tyr Ala Val  Arg Gly Lys Ser Asp  Lys Asp Val 
    4340                 4345                 4350             


Lys Pro  Thr Ala Leu Ala Gln  Lys Ile Glu Glu Tyr  Ser Gln Gln 
    4355                 4360                 4365             


Leu Glu  Gly Leu Thr Asn Asp  Val His Thr Leu Glu  Ala Tyr Gly 
    4370                 4375                 4380             


Val Asp  Ser Leu Lys Thr Arg  Tyr Pro Asp Leu Leu  Pro Phe Pro 
    4385                 4390                 4395             


Gln Ile  Pro Asn Asp Arg Phe  Thr Ser Glu Val Ala  Met Arg Val 
    4400                 4405                 4410             


Met Glu  Cys Thr Ala Cys Ile  Ile Ile Lys Leu Glu  Asn Phe Met 
    4415                 4420                 4425             


Gln Gln  Lys Val 
    4430         


<210>  3074
<211>  1485
<212>  DNA
<213>  Homosapiens

<400>  3074
ggacctgcag cctcccaggt ggctgggaag aactctccaa caataaatac atttgataag     60

aaagatggct ttaaaagtgc tactagaaca agagaaaacg tttttcactc ttttagtatt    120

actaggctat ttgtcatgta aagtgacttg tgaatcagga gactgtagac agcaagaatt    180

cagggatcgg tctggaaact gtgttccctg caaccagtgt gggccaggca tggagttgtc    240

taaggaatgt ggcttcggct atggggagga tgcacagtgt gtgacgtgcc ggctgcacag    300

gttcaaggag gactggggct tccagaaatg caagccctgt ctggactgcg cagtggtgaa    360

ccgctttcag aaggcaaatt gttcagccac cagtgatgcc atctgcgggg actgcttgcc    420

aggattttat aggaagacga aacttgtcgg ctttcaagac atggagtgtg tgccttgtgg    480

agaccctcct cctccttacg aaccgcactg tgccagcaag gtcaacctcg tgaagatcgc    540

gtccacggcc tccagcccac gggacacggc gctggctgcc gttatctgca gcgctctggc    600

caccgtcctg ctggccctgc tcatcctctg tgtcatctat tgtaagagac agtttatgga    660

gaagaaaccc agctggtctc tgcggtcaca ggacattcag tacaacggct ctgagctgtc    720

gtgttttgac agacctcagc tccacgaata tgcccacaga gcctgctgcc agtgccgccg    780

tgactcagtg cagacctgcg ggccggtgcg cttgctccca tccatgtgct gtgaggaggc    840

ctgcagcccc aacccggcga ctcttggttg tggggtgcat tctgcagcca gtcttcaggc    900

aagaaacgca ggcccagccg gggagatggt gccgactttc ttcggatccc tcacgcagtc    960

catctgtggc gagttttcag atgcctggcc tctgatgcag aatcccatgg gtggtgacaa   1020

catctctttt tgtgactctt atcctgaact cactggagaa gacattcatt ctctcaatcc   1080

agaacttgaa agctcaacgt ctttggattc aaatagcagt caagatttgg ttggtggggc   1140

tgttccagtc cagtctcatt ctgaaaactt tacagcagct actgatttat ctagatataa   1200

caacacactg gtagaatcag catcaactca ggatgcacta actatgagaa gccagctaga   1260

tcaggagagt ggtgctgtca tccacccagc cactcagacg tccctccagg taaggcagcg   1320

actgggttcc ctgtgaacac agcactgact tacagtagat cagaactctg ttcccagcat   1380

aagatttggg ggaacctgat gagttttttt tttgcatctt taataatttc ttgtatgttg   1440

tagagtatgt tttaaaataa atttcaagta tttttttaaa aaact                   1485


<210>  3075
<211>  423
<212>  PRT
<213>  Homosapiens

<400>  3075

Met Ala Leu Lys Val Leu Leu Glu Gln Glu Lys Thr Phe Phe Thr Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Tyr Leu Ser Cys Lys Val Thr Cys Glu Ser Gly 
            20                  25                  30          


Asp Cys Arg Gln Gln Glu Phe Arg Asp Arg Ser Gly Asn Cys Val Pro 
        35                  40                  45              


Cys Asn Gln Cys Gly Pro Gly Met Glu Leu Ser Lys Glu Cys Gly Phe 
    50                  55                  60                  


Gly Tyr Gly Glu Asp Ala Gln Cys Val Thr Cys Arg Leu His Arg Phe 
65                  70                  75                  80  


Lys Glu Asp Trp Gly Phe Gln Lys Cys Lys Pro Cys Leu Asp Cys Ala 
                85                  90                  95      


Val Val Asn Arg Phe Gln Lys Ala Asn Cys Ser Ala Thr Ser Asp Ala 
            100                 105                 110         


Ile Cys Gly Asp Cys Leu Pro Gly Phe Tyr Arg Lys Thr Lys Leu Val 
        115                 120                 125             


Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp Pro Pro Pro Pro 
    130                 135                 140                 


Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val Lys Ile Ala Ser 
145                 150                 155                 160 


Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu Ala Ala Val Ile Cys Ser 
                165                 170                 175     


Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu Cys Val Ile Tyr 
            180                 185                 190         


Cys Lys Arg Gln Phe Met Glu Lys Lys Pro Ser Trp Ser Leu Arg Ser 
        195                 200                 205             


Gln Asp Ile Gln Tyr Asn Gly Ser Glu Leu Ser Cys Phe Asp Arg Pro 
    210                 215                 220                 


Gln Leu His Glu Tyr Ala His Arg Ala Cys Cys Gln Cys Arg Arg Asp 
225                 230                 235                 240 


Ser Val Gln Thr Cys Gly Pro Val Arg Leu Leu Pro Ser Met Cys Cys 
                245                 250                 255     


Glu Glu Ala Cys Ser Pro Asn Pro Ala Thr Leu Gly Cys Gly Val His 
            260                 265                 270         


Ser Ala Ala Ser Leu Gln Ala Arg Asn Ala Gly Pro Ala Gly Glu Met 
        275                 280                 285             


Val Pro Thr Phe Phe Gly Ser Leu Thr Gln Ser Ile Cys Gly Glu Phe 
    290                 295                 300                 


Ser Asp Ala Trp Pro Leu Met Gln Asn Pro Met Gly Gly Asp Asn Ile 
305                 310                 315                 320 


Ser Phe Cys Asp Ser Tyr Pro Glu Leu Thr Gly Glu Asp Ile His Ser 
                325                 330                 335     


Leu Asn Pro Glu Leu Glu Ser Ser Thr Ser Leu Asp Ser Asn Ser Ser 
            340                 345                 350         


Gln Asp Leu Val Gly Gly Ala Val Pro Val Gln Ser His Ser Glu Asn 
        355                 360                 365             


Phe Thr Ala Ala Thr Asp Leu Ser Arg Tyr Asn Asn Thr Leu Val Glu 
    370                 375                 380                 


Ser Ala Ser Thr Gln Asp Ala Leu Thr Met Arg Ser Gln Leu Asp Gln 
385                 390                 395                 400 


Glu Ser Gly Ala Val Ile His Pro Ala Thr Gln Thr Ser Leu Gln Val 
                405                 410                 415     


Arg Gln Arg Leu Gly Ser Leu 
            420             


<210>  3076
<211>  4283
<212>  DNA
<213>  Homosapiens

<400>  3076
gggagggtaa ctacctgctg aaagtgaact ttctttgata tccatgcata tatataaact     60

cagccctgcc tttgatgttc agcaactgat tcactgatca gattacaggc atttcatctc    120

cctgctcgtc tgcctttgat ctgcatggtt aattttattt tcctggattt gaagtttcgt    180

ctgggcttgt gctgacatac atttttggga aggtagaagc atttggcaca gaagtgctgc    240

caggagaaac taagttgctg aacggaactc tccaacaata aatacatttg ataagaaaga    300

tggctttaaa agtgctacta gaacaagaga aaacgttttt cactctttta gtattactag    360

gctatttgtc atgtaaagtg acttgtgaat caggagactg tagacagcaa gaattcaggg    420

atcggtctgg aaactgtgtt ccctgcaacc agtgtgggcc aggcatggag ttgtctaagg    480

aatgtggctt cggctatggg gaggatgcac agtgtgtgac gtgccggctg cacaggttca    540

aggaggactg gggcttccag aaatgcaagc cctgtctgga ctgcgcagtg gtgaaccgct    600

ttcagaaggc aaattgttca gccaccagtg atgccatctg cggggactgc ttgccaggat    660

tttataggaa gacgaaactt gtcggctttc aagacatgga gtgtgtgcct tgtggagacc    720

ctcctcctcc ttacgaaccg cactgtgcca gcaaggtcaa cctcgtgaag atcgcgtcca    780

cggcctccag cccacgggac acggcgctgg ctgccgttat ctgcagcgct ctggccaccg    840

tcctgctggc cctgctcatc ctctgtgtca tctattgtaa gagacagttt atggagaaga    900

aacccagctg gtctctgcgg tcacaggaca ttcagtacaa cggctctgag ctgtcgtgtt    960

ttgacagacc tcagctccac gaatatgccc acagagcctg ctgccagtgc cgccgtgact   1020

cagtgcagac ctgcgggccg gtgcgcttgc tcccatccat gtgctgtgag gaggcctgca   1080

gccccaaccc ggcgactctt ggttgtgggg tgcattctgc agccagtctt caggcaagaa   1140

acgcaggccc agccggggag atggtgccga ctttcttcgg atccctcacg cagtccatct   1200

gtggcgagtt ttcagatgcc tggcctctga tgcagaatcc catgggtggt gacaacatct   1260

ctttttgtga ctcttatcct gaactcactg gagaagacat tcattctctc aatccagaac   1320

ttgaaagctc aacgtctttg gattcaaata gcagtcaaga tttggttggt ggggctgttc   1380

cagtccagtc tcattctgaa aactttacag cagctactga tttatctaga tataacaaca   1440

cactggtaga atcagcatca actcaggatg cactaactat gagaagccag ctagatcagg   1500

agagtggtgc tgtcatccac ccagccactc agacgtccct ccaggaagct taaagaacct   1560

gcttctttct gcagtagaag cgtgtgctgg aacccaaaga gtactccttt gttaggctta   1620

tggactgagc agtctggacc ttgcatggct tctggggcaa aaataaatct gaaccaaact   1680

gacggcattt gaagcctttc agccagttgc ttctgagcca gaccagctgt aagctgaaac   1740

ctcaatgaat aacaagaaaa gactccaggc cgactcatga tactctgcat ctttcctaca   1800

tgagaagctt ctctgccaca aaagtgactt caaagacgga tgggttgagc tggcagccta   1860

tgagattgtg gacatataac aagaaacaga aatgccctca tgcttatttt catggtgatt   1920

gtggttttac aagactgaag acccagagta tactttttct ttccagaaat aatttcatac   1980

cgcctatgaa atatcagata aattacctta gcttttatgt agaatgggtt caaaagtgag   2040

tgtttctatt tgagaaggac actttttcat catctaaact gattcgcata ggtggttaga   2100

atggccctca tattgcctgc ctaaatcttg ggtttattag atgaagttta ctgaatcaga   2160

ggaatcagac agaggaggat agctctttcc agaatccaca cttctgacct cagcctcggt   2220

ctcatgaaca cccgctgatc tcaggagaac acctgggcta gggaatgtgg tcgagaaagg   2280

gcagcccatt gcccagaatt aacacatatt gtagagactt gtatgcaaag gttggcatat   2340

ttatatgaaa attagttgct atagaaacat ttgttgcatc tgtccctctg cctgagctta   2400

gaaggttata gaaaaagggt atttataaac ataaatgacc ttttacttgc attgtatctt   2460

atactaaagg ctttagaaat tacaacatat caggttcccc tactactgaa gtagccttcc   2520

gtgagaacac accacatgtt aggactagaa gaaaatgcac aatttgtagg ggtttggatg   2580

aagcagctgt aactgcccta gtgtagtttg accaggacat tgtcgtgctc cttccaattg   2640

tgtaagatta gttagcacat catctcctac tttagccatc cggtgttgga tttaagagga   2700

cggtgcttct ttctattaaa gtgctccatc ccctaccatc tacacattag cattgtctct   2760

agagctaaga cagaaattaa ccccgttcag tcacaaagca gggaatggtt catttactct   2820

taatctttat gccctggaga agacctactt gaacagggca tattttttag acttctgaac   2880

atcagtatgt tcgagggtac tatgatattt tggtttggaa ttgccctgcc caagtcactg   2940

tcttttaact tttaaactga atattaaaat gtatctgtct ttcctagtat gtttttatct   3000

tctcatgtat tatccatggt tttctctgtt tgtgacagat tagtaaaatt taatgagccc   3060

tctttcttgt ggccgtttct ccatagtttt aggttttgat atgtgtttac tagcttgcct   3120

gtgtctggta catctcatga cctcaattcc ctcacctgaa ataggaaatg agaatgtttc   3180

attgtagccc caagcggtca tgtcaaccta gtgcctagtc ataattaatt gacttttcct   3240

gtattacttc tttttttaag tataaaccaa tgatcctttg gtagtcaaga actcttagga   3300

acattgcctt ttggacatgt aaaatattta ggatttgacc acacaatggc tatgaaaatg   3360

caagtagttt cctcgcgtga cctcaccatg attcacatac gtgccactgt ttgaaatctg   3420

gtctgtttgc atttctgtta tgacagagag atgatgtttg catttctgtt atgacagaga   3480

gatgatgaaa gtaggcaggg ctgtgttcct ttgtgtagcc tgtatatatt ttccatatgt   3540

agagccctga ttaacttcaa ggacaaacac tggctggaga aagccagact gatgggaatg   3600

agactttggc caaaaatccc aaaacatcat tttcaatcag tagagaagtg cttagggttg   3660

aaaattgatt tcatttgcta ctgaatttgg taaatcctgg gtaactttta tcaagatgaa   3720

gacattttac cctacctact ctagaaatat acaacaatgt tatattttac actccttgga   3780

aacatttgag gaaaaaaatg caatttgcac ttcactttgt tggaatatcc catagcactc   3840

aataaactca gctgctagag tgccgatgtc aggagggctg tgtcgggtaa tgcgtgtggc   3900

tgaatgggca taaccactgt ggcttcttgt gctgcagaag ctcgttgaca agactgagga   3960

ggatttcaag agcaaccaag taaagtcatg aattttctaa ttttgtgtat atggaatata   4020

tttttaaata gagatttttc tactttagat aatgtgttaa tattgctatt acctaggtta   4080

agcactattg tctgtgctag taagaaaaag aaaggaaaac catcattgct ttatagtagc   4140

ttatatcaat ttagatttca tcattactat tttgcatact ggaatttata aatgtgtaaa   4200

ttatcatttt cttagttttg taataccttt tttatttgtg aataaaatta tcacctggta   4260

ttcttaaaaa aaaaaaaaaa aaa                                           4283


<210>  3077
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  3077

Met Ala Leu Lys Val Leu Leu Glu Gln Glu Lys Thr Phe Phe Thr Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Tyr Leu Ser Cys Lys Val Thr Cys Glu Ser Gly 
            20                  25                  30          


Asp Cys Arg Gln Gln Glu Phe Arg Asp Arg Ser Gly Asn Cys Val Pro 
        35                  40                  45              


Cys Asn Gln Cys Gly Pro Gly Met Glu Leu Ser Lys Glu Cys Gly Phe 
    50                  55                  60                  


Gly Tyr Gly Glu Asp Ala Gln Cys Val Thr Cys Arg Leu His Arg Phe 
65                  70                  75                  80  


Lys Glu Asp Trp Gly Phe Gln Lys Cys Lys Pro Cys Leu Asp Cys Ala 
                85                  90                  95      


Val Val Asn Arg Phe Gln Lys Ala Asn Cys Ser Ala Thr Ser Asp Ala 
            100                 105                 110         


Ile Cys Gly Asp Cys Leu Pro Gly Phe Tyr Arg Lys Thr Lys Leu Val 
        115                 120                 125             


Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp Pro Pro Pro Pro 
    130                 135                 140                 


Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val Lys Ile Ala Ser 
145                 150                 155                 160 


Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu Ala Ala Val Ile Cys Ser 
                165                 170                 175     


Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu Cys Val Ile Tyr 
            180                 185                 190         


Cys Lys Arg Gln Phe Met Glu Lys Lys Pro Ser Trp Ser Leu Arg Ser 
        195                 200                 205             


Gln Asp Ile Gln Tyr Asn Gly Ser Glu Leu Ser Cys Phe Asp Arg Pro 
    210                 215                 220                 


Gln Leu His Glu Tyr Ala His Arg Ala Cys Cys Gln Cys Arg Arg Asp 
225                 230                 235                 240 


Ser Val Gln Thr Cys Gly Pro Val Arg Leu Leu Pro Ser Met Cys Cys 
                245                 250                 255     


Glu Glu Ala Cys Ser Pro Asn Pro Ala Thr Leu Gly Cys Gly Val His 
            260                 265                 270         


Ser Ala Ala Ser Leu Gln Ala Arg Asn Ala Gly Pro Ala Gly Glu Met 
        275                 280                 285             


Val Pro Thr Phe Phe Gly Ser Leu Thr Gln Ser Ile Cys Gly Glu Phe 
    290                 295                 300                 


Ser Asp Ala Trp Pro Leu Met Gln Asn Pro Met Gly Gly Asp Asn Ile 
305                 310                 315                 320 


Ser Phe Cys Asp Ser Tyr Pro Glu Leu Thr Gly Glu Asp Ile His Ser 
                325                 330                 335     


Leu Asn Pro Glu Leu Glu Ser Ser Thr Ser Leu Asp Ser Asn Ser Ser 
            340                 345                 350         


Gln Asp Leu Val Gly Gly Ala Val Pro Val Gln Ser His Ser Glu Asn 
        355                 360                 365             


Phe Thr Ala Ala Thr Asp Leu Ser Arg Tyr Asn Asn Thr Leu Val Glu 
    370                 375                 380                 


Ser Ala Ser Thr Gln Asp Ala Leu Thr Met Arg Ser Gln Leu Asp Gln 
385                 390                 395                 400 


Glu Ser Gly Ala Val Ile His Pro Ala Thr Gln Thr Ser Leu Gln Glu 
                405                 410                 415     


Ala 
    


<210>  3078
<211>  2727
<212>  DNA
<213>  Homosapiens

<400>  3078
cattgccaga gagctagtgt gatcctttgg tagtgtcact acattcagat ttctcatggt     60

gctagaattc ttgtgtgggt ccttctcatc tggagatgct agcacttcta atttgtgtaa    120

ttatttttgt ttgggtagga ttttttcttt ttctttcctt ttctataata ttattgttat    180

ttttttcttc tttccctttc cctcctccct aggggtgtgg ctgtagagca tgctgggtag    240

ggtcttttgg ctttgcttct gtagccctaa tgcacttctg ccagcaggtt ttatattggg    300

tgtgtggttt gacctacaag ccagtagatg gcgccatggg taagagctgg ctgttgccag    360

tgctgctggc tgtgtacttg atccttgttt attgggagga gctttctgct gccccaggaa    420

tgggctgatt tcctgagtac acattaatct gagctccctc agccctaggg gtagggggat    480

tgggggcaca agatgggtgg agccagatag ggaagattcc cccagtgttg tcctgctccc    540

agtccaggtt tgggacaatg ccagcagcgt ttccctgtgt ctttccccca caaagtctcc    600

aagtctctcc tcaaatgagc tccaaggctt gggagaaaca atctcttcct ctgcccgggt    660

tgcgtggatc tccagtggaa aggtgagaca gagggatgct gtctgcctct ctcacttact    720

gaggcttcac tcacttctat cagtcgaatg ctgtcctgag ggctgcttgc ctgcaatgtc    780

ctccgcaaga tctgggatgt ccttcataat tccggggaat tgccatttcc tttcttgaat    840

taaagctcac agagttggtc tttatgtact tgcttgctat ttccaaatga ctgaggcatg    900

ctaaaagcct gtaatctgcc atcttggaaa aaacatcctt gcatccttaa gagaaatggc    960

acttggtgtt gatacatggt gtttctacat tgctgaattc actttgaaaa tatatgtata   1020

ttttaaaatc tacatttata tgtgagactg gtgtaaaaat atcttttatt ctactgtatt   1080

tgtgcaattt tggaatcagt tatattaata tactaaatga gttggcaatt tttctttttt   1140

actattatcc aaaaaaatta taaaagacat aattgttgct ttcttataga tttagtaaaa   1200

acctcatcgt gtccttttgt ggagcgatgg tgagagatat ttttactgta aatgtaactt   1260

gcgtattttt cacctgtgag gcagaggttg caatgagcca agattgtgcc actgcactcc   1320

agcctgcgtg acacagcaag accctgtctc aaaaaaaaga aagaaaatca acttaaaatg   1380

cactccttga atatttctga gtgtattttt ataccacgta tgttccttga actaacttct   1440

tttcttttct aggaagaacc ggaactatga tttgtgcctt ccttattgcc tccgaaatat   1500

ttttaactgc agaggaaagc ctgtattatt ttggagaaag gcgaacagat aaaacgcaca   1560

gcagtaaatt tcagggacta gaaactcctt ctcagtagag acaaggtttc accctgttgg   1620

cgaggctggt ctcaaactcc tgacgcccag tgatctgccc acctcggcct cccaatgtgc   1680

tgggattaca ggcgggagcc accatgatgg ccaacttttg aattctgaac cagttgattg   1740

agtaccagag ctcttcaata ccttgaagaa agattcaggg gagagccgtt gtgaacagct   1800

tgccccaggg aaaggacaag gctgagagaa ttccagggct tccttgagaa aacagaattg   1860

aggaaatgca aagtgaagaa ttctagcatc aggaacaaga gaagaatgat ggaaaacctg   1920

ctactgagat atgttggata ttttgcacaa gtgaaacatc tctacaactg gaatctccct   1980

ccaagacgga tactctttat aataagattc attatttatt cgattcgtgg tgttggaaca   2040

ggcgatgtat gtgatctaaa attccaaata gtaatggaga aaaagatact gcatgacatt   2100

gaaacagctg gtgtattaac taatgtatat gacagtccat ctctgtacga tgatgtgaaa   2160

gtgcagtttt tctcttcaaa tcttcctaaa tactatgaca attgttcatt tttcttctgg   2220

ttcaacacat cttttattca aaataacaga gagaaattta gatattttat taaacttgga   2280

agtcattaat gccatataaa gcaatgctaa gagagtcagc atgtgttact gatgtgttgc   2340

tgaagattaa agtattttta agtctcacca aaaaggtgga aggagccaac tgagacacaa   2400

aaaaggggct gaggttctat tcacggcttt atctaccaag aaatgaattg gataatccac   2460

atcaacaaaa agcatggaaa atttatccac cagaatttgc cgtggagata ctttttggcg   2520

agaaatgact tccaatgacg tagctggatc cgattaagta tagtttcccc ttccccttct   2580

gggaaagaat taatgttctt tccaacccct gccatgtgca tgttcatatg tcctaagtct   2640

tccttgatga tgtatctata tttatatatg tttatatatg ttcttcataa atctattaaa   2700

tatatataga taaaaaaaaa aaaaaaa                                       2727


<210>  3079
<211>  3565
<212>  DNA
<213>  Homosapiens

<400>  3079
ccggtgcagc ggctggcgat cggccgcgga ggtgcgtgca gggcccgcgc cgccgccggt     60

atctccaccg ccaacacctc agccactgcc actgccacag ccacacgagg ccccccaccg    120

tgcgctccgc cgctgcggtc ccggatccgc gctccacgcc cgcagcccgc ggcgccacca    180

gcccagcatg caccagaaaa ccccagaaat ttactccgtg gagctcagcg gaactaagga    240

catcgtgaaa acagacaagg gggatggcaa ggagaagtat aggggtctga agaacaactg    300

cctggaactc aaaaagaaaa atcacaaaga ggagtttcag aaagaactcc atctggatga    360

ccacaaactc agcaataggg aattggaaga gaaatatggc acagacatca ttatgggtct    420

ctccagcacc agagctgccg agctcctggc ccgggatggg cccaactccc tcacccctcc    480

caagcagacg cctgagatcg tcaagttcct caagcagatg gtgggggggt tctctatcct    540

cctgtgggtg ggcgcctttc tctgttggat tgcatatggg attcagtact ccagcgacaa    600

gtctgcatcc ctgaacaacg tgtacttggg ctgtgtgctt ggtctggtgg tcattttaac    660

ggggatcttt gcttattacc aagaggcaaa aagcaccaac atcatgtcca gcttcaataa    720

gatgatccct cagcaagctc tcgtcatccg agattccgag aagaagacca tcccttcaga    780

gcagctggtg gtgggggaca ttgtggaggt caaaggagga gaccagatcc ctgcagacat    840

cagggtgctg tcttctcagg ggtgtcgggt ggataactca tctctcacgg gggagtctga    900

gccccagccc cgctcctctg agtttaccca tgaaaacccc ctggaaacaa agaacatctg    960

cttctattcc acaacgtgtc tggaaggcac tgtcaccggc atggttatca acacgggtga   1020

ccgcaccatc attggccata ttgcctcatt ggcctcagga gttggaaatg agaagacgcc   1080

cattgccatt gagatcgagc actttgttca cattgtggca ggagtggctg tctccatcgg   1140

catccttttc ttcatcatcg ctgtgtccct gaagtatcaa gtcctggact ccatcatctt   1200

cctcattggc atcattgtgg ccaatgtgcc cgagggcctc ctggccactg tcactgtgac   1260

cctgtcgctg acagcaaaac ggatggccaa gaagaactgc ctggtgaaga acctggaggc   1320

tgtggagacc ctcggctcca cctccatcat ctgctcggac aagactggga cactgaccca   1380

gaacaggatg acagtggccc atctgtggtt cgacaatcag atctttgtgg ctgacaccag   1440

tgaggaccat tcaaaccaag tctttgacca aagctctagg acttgggcct ccttatccaa   1500

gataataaca ttgtgtaacc gagcagagtt caagccagga caggaaaatg tccccatcat   1560

gaagaaagct gtgattggag atgcctcaga aactgctctt ttaaaattct cagaggtcat   1620

tttgggtgat gtgatggaaa ttagaaaaag aaaccgcaaa gtagctgaaa tcccttttaa   1680

ctctactaat aaatttcagc tctccatcca cgagatggat gacccccacg gcaagcgctt   1740

cctcatggtg atgaaggggg cccctgagcg cattctagag aaatgcagca ccatcatgat   1800

caacggcgag gagcacccac tggacaagag cactgccaag accttccaca cagcctacat   1860

ggagctgggc gggttgggcg agcgtgtgct gggtttctgt catctctacc tgccagcaga   1920

cgagtttcca gaaacctact catttgacat agacgctatg aactttccga cctccaacct   1980

ctgttttgtg ggactcttgt caatgatcga tccccctcgg tccaccgtgc cagatgcagt   2040

caccaaatgc cggagtgcag ggatcaaggt tattatggtt actggtgatc atcccatcac   2100

agccaaagct attgccaaga gtgtggggat catttcagcc aacagtgaaa cagtggaaga   2160

cattgcacat cgcctcaaca ttgctgtgga gcaagttaac aaacgggatg ccaaggccgc   2220

tgtggtgact ggcatggagc tgaaggacat gagctcagaa cagctggatg agatcttagc   2280

caactaccag gagattgtct ttgcccggac atccccccag cagaagctga tcattgtgga   2340

gggctgtcag aggcaggatg ctgttgttgc tgtgaccggg gatggagtta atgactctcc   2400

ggctctaaag aaggcagaca ttgggattgc catggggata gcaggttctg atgcagccaa   2460

aaatgcagcc gacatggtct tgctggacga caacttcgca tccatcgtca caggggtgga   2520

ggaaggtcgc ctgatctttg acaacctcaa gaagactatt gcttattccc tgaccaagaa   2580

cattgccgag ctgtgcccct ttctgatcta catcattgtc gggctccccc tgcccattgg   2640

caccatcacc attctgttca ttgacttggg gacagacatt atcccctcca ttgccttggc   2700

gtacgagaaa gctgaaagtg acatcatgaa caggaagcct cgccacaaga ataaggacag   2760

gctggtgaac cagccgctcg ctgtgtactc atacctgcac attggcctca tgcaagccct   2820

gggagctttc cttgtgtatt tcaccgtcta tgcacaagag ggctttctgc cccgcactct   2880

cattaacctg cgggtagaat gggagaagga ctacgtgaat gacttgaaag acagctatgg   2940

gcaggaatgg acaaggtacc agagggaata cctagaatgg acgggctaca cggctttctt   3000

tgttggcatc ctagtccagc aaatagcaga tctgatcatc aggaaaaccc ggaggaattc   3060

catcttccag cagggtctct tcagaaataa agtcatctgg gtggggatca cctcacagat   3120

catcattggt ctgatcctct cctatggcct cggaagtgtc acagccttga gtttcaccat   3180

gcttagggct cagtactggt ttgtggctgt gccgcacgcc atcctgatct gggtgtatga   3240

tgaggtgcgg aagctcttca tcaggctcta ccctggaagc tggtgggata agaacatgta   3300

ttattaagac cacctccctt cctatgtctc tcagcagcac gttggggcac acttgttcat   3360

cttctgaccg tttgctgggc tattcccctg cagtgcagac atcgtcaaaa ttcagacaag   3420

aggaaatttt catgcagaaa gctgtatgca ggatgctcac tgatgttttg cactttaaaa   3480

ctgaaattca actctttata taggattttc ttttctatct ccatctcctc attaaaaaat   3540

acgtacattt cgaggtaatg gtata                                         3565


<210>  3080
<211>  1039
<212>  PRT
<213>  Homosapiens

<400>  3080

Met His Gln Lys Thr Pro Glu Ile Tyr Ser Val Glu Leu Ser Gly Thr 
1               5                   10                  15      


Lys Asp Ile Val Lys Thr Asp Lys Gly Asp Gly Lys Glu Lys Tyr Arg 
            20                  25                  30          


Gly Leu Lys Asn Asn Cys Leu Glu Leu Lys Lys Lys Asn His Lys Glu 
        35                  40                  45              


Glu Phe Gln Lys Glu Leu His Leu Asp Asp His Lys Leu Ser Asn Arg 
    50                  55                  60                  


Glu Leu Glu Glu Lys Tyr Gly Thr Asp Ile Ile Met Gly Leu Ser Ser 
65                  70                  75                  80  


Thr Arg Ala Ala Glu Leu Leu Ala Arg Asp Gly Pro Asn Ser Leu Thr 
                85                  90                  95      


Pro Pro Lys Gln Thr Pro Glu Ile Val Lys Phe Leu Lys Gln Met Val 
            100                 105                 110         


Gly Gly Phe Ser Ile Leu Leu Trp Val Gly Ala Phe Leu Cys Trp Ile 
        115                 120                 125             


Ala Tyr Gly Ile Gln Tyr Ser Ser Asp Lys Ser Ala Ser Leu Asn Asn 
    130                 135                 140                 


Val Tyr Leu Gly Cys Val Leu Gly Leu Val Val Ile Leu Thr Gly Ile 
145                 150                 155                 160 


Phe Ala Tyr Tyr Gln Glu Ala Lys Ser Thr Asn Ile Met Ser Ser Phe 
                165                 170                 175     


Asn Lys Met Ile Pro Gln Gln Ala Leu Val Ile Arg Asp Ser Glu Lys 
            180                 185                 190         


Lys Thr Ile Pro Ser Glu Gln Leu Val Val Gly Asp Ile Val Glu Val 
        195                 200                 205             


Lys Gly Gly Asp Gln Ile Pro Ala Asp Ile Arg Val Leu Ser Ser Gln 
    210                 215                 220                 


Gly Cys Arg Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln 
225                 230                 235                 240 


Pro Arg Ser Ser Glu Phe Thr His Glu Asn Pro Leu Glu Thr Lys Asn 
                245                 250                 255     


Ile Cys Phe Tyr Ser Thr Thr Cys Leu Glu Gly Thr Val Thr Gly Met 
            260                 265                 270         


Val Ile Asn Thr Gly Asp Arg Thr Ile Ile Gly His Ile Ala Ser Leu 
        275                 280                 285             


Ala Ser Gly Val Gly Asn Glu Lys Thr Pro Ile Ala Ile Glu Ile Glu 
    290                 295                 300                 


His Phe Val His Ile Val Ala Gly Val Ala Val Ser Ile Gly Ile Leu 
305                 310                 315                 320 


Phe Phe Ile Ile Ala Val Ser Leu Lys Tyr Gln Val Leu Asp Ser Ile 
                325                 330                 335     


Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu 
            340                 345                 350         


Ala Thr Val Thr Val Thr Leu Ser Leu Thr Ala Lys Arg Met Ala Lys 
        355                 360                 365             


Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser 
    370                 375                 380                 


Thr Ser Ile Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg 
385                 390                 395                 400 


Met Thr Val Ala His Leu Trp Phe Asp Asn Gln Ile Phe Val Ala Asp 
                405                 410                 415     


Thr Ser Glu Asp His Ser Asn Gln Val Phe Asp Gln Ser Ser Arg Thr 
            420                 425                 430         


Trp Ala Ser Leu Ser Lys Ile Ile Thr Leu Cys Asn Arg Ala Glu Phe 
        435                 440                 445             


Lys Pro Gly Gln Glu Asn Val Pro Ile Met Lys Lys Ala Val Ile Gly 
    450                 455                 460                 


Asp Ala Ser Glu Thr Ala Leu Leu Lys Phe Ser Glu Val Ile Leu Gly 
465                 470                 475                 480 


Asp Val Met Glu Ile Arg Lys Arg Asn Arg Lys Val Ala Glu Ile Pro 
                485                 490                 495     


Phe Asn Ser Thr Asn Lys Phe Gln Leu Ser Ile His Glu Met Asp Asp 
            500                 505                 510         


Pro His Gly Lys Arg Phe Leu Met Val Met Lys Gly Ala Pro Glu Arg 
        515                 520                 525             


Ile Leu Glu Lys Cys Ser Thr Ile Met Ile Asn Gly Glu Glu His Pro 
    530                 535                 540                 


Leu Asp Lys Ser Thr Ala Lys Thr Phe His Thr Ala Tyr Met Glu Leu 
545                 550                 555                 560 


Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Tyr Leu Pro 
                565                 570                 575     


Ala Asp Glu Phe Pro Glu Thr Tyr Ser Phe Asp Ile Asp Ala Met Asn 
            580                 585                 590         


Phe Pro Thr Ser Asn Leu Cys Phe Val Gly Leu Leu Ser Met Ile Asp 
        595                 600                 605             


Pro Pro Arg Ser Thr Val Pro Asp Ala Val Thr Lys Cys Arg Ser Ala 
    610                 615                 620                 


Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys 
625                 630                 635                 640 


Ala Ile Ala Lys Ser Val Gly Ile Ile Ser Ala Asn Ser Glu Thr Val 
                645                 650                 655     


Glu Asp Ile Ala His Arg Leu Asn Ile Ala Val Glu Gln Val Asn Lys 
            660                 665                 670         


Arg Asp Ala Lys Ala Ala Val Val Thr Gly Met Glu Leu Lys Asp Met 
        675                 680                 685             


Ser Ser Glu Gln Leu Asp Glu Ile Leu Ala Asn Tyr Gln Glu Ile Val 
    690                 695                 700                 


Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys 
705                 710                 715                 720 


Gln Arg Gln Asp Ala Val Val Ala Val Thr Gly Asp Gly Val Asn Asp 
                725                 730                 735     


Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Met Gly Ile Ala 
            740                 745                 750         


Gly Ser Asp Ala Ala Lys Asn Ala Ala Asp Met Val Leu Leu Asp Asp 
        755                 760                 765             


Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe 
    770                 775                 780                 


Asp Asn Leu Lys Lys Thr Ile Ala Tyr Ser Leu Thr Lys Asn Ile Ala 
785                 790                 795                 800 


Glu Leu Cys Pro Phe Leu Ile Tyr Ile Ile Val Gly Leu Pro Leu Pro 
                805                 810                 815     


Ile Gly Thr Ile Thr Ile Leu Phe Ile Asp Leu Gly Thr Asp Ile Ile 
            820                 825                 830         


Pro Ser Ile Ala Leu Ala Tyr Glu Lys Ala Glu Ser Asp Ile Met Asn 
        835                 840                 845             


Arg Lys Pro Arg His Lys Asn Lys Asp Arg Leu Val Asn Gln Pro Leu 
    850                 855                 860                 


Ala Val Tyr Ser Tyr Leu His Ile Gly Leu Met Gln Ala Leu Gly Ala 
865                 870                 875                 880 


Phe Leu Val Tyr Phe Thr Val Tyr Ala Gln Glu Gly Phe Leu Pro Arg 
                885                 890                 895     


Thr Leu Ile Asn Leu Arg Val Glu Trp Glu Lys Asp Tyr Val Asn Asp 
            900                 905                 910         


Leu Lys Asp Ser Tyr Gly Gln Glu Trp Thr Arg Tyr Gln Arg Glu Tyr 
        915                 920                 925             


Leu Glu Trp Thr Gly Tyr Thr Ala Phe Phe Val Gly Ile Leu Val Gln 
    930                 935                 940                 


Gln Ile Ala Asp Leu Ile Ile Arg Lys Thr Arg Arg Asn Ser Ile Phe 
945                 950                 955                 960 


Gln Gln Gly Leu Phe Arg Asn Lys Val Ile Trp Val Gly Ile Thr Ser 
                965                 970                 975     


Gln Ile Ile Ile Gly Leu Ile Leu Ser Tyr Gly Leu Gly Ser Val Thr 
            980                 985                 990         


Ala Leu Ser Phe Thr Met Leu Arg  Ala Gln Tyr Trp Phe  Val Ala Val 
        995                 1000                 1005             


Pro His  Ala Ile Leu Ile Trp  Val Tyr Asp Glu Val  Arg Lys Leu 
    1010                 1015                 1020             


Phe Ile  Arg Leu Tyr Pro Gly  Ser Trp Trp Asp Lys  Asn Met Tyr 
    1025                 1030                 1035             


Tyr 
    


<210>  3081
<211>  1206
<212>  DNA
<213>  Homosapiens

<400>  3081
atgcgtttac cgcagcataa acgcgcactg cgagctggcc atacccagcg agaggcgcag     60

agtgcgctga aggggggcgg gagcggcgcc gcgggcgcgg tccagcatgc ccccaagccc    120

gttccctccc cggggcgaaa gccaacagca cccactggtc gcctgcgggc tgcgagggcg    180

gctttcaccg ctgcgcggcg catccagcct tgggacgagg cccctctcgg caaggaatct    240

gaagaggtcc agtgttggga cgggggacac gtggtagggg cgcccagggg ctcaggtctc    300

ctgtccccgc ctccccgctc tccccacgcg caggcaggcc cgcgggtgga gcgcagctct    360

ctgggagagc acgagggcct tcgcctggct ttgcaaattc aggaaggaga agacccaggg    420

ctcgaggcca ctgccgcgcg cccttccctg cccatgatga tcctcacgac agtccccacc    480

accttcgcca acgcccgccg gcccctcaag gagaacgcgg tgacgtgggg agcgcacagc    540

aaggaccagg aggacggagg ccttttcagc agcgacactg agggcgaccc cgagaaggca    600

gagattgacc cggaggagca tccatctcca caagaccaac acgcaccatg gcgaccacag    660

cccattctcc ctgcgcaccc ccacacctcg ccaggcctct ctaatctcag ccggggtcca    720

agtgaacttg gcatcaggag ctgcgcctgg gaacgcgcgg agctgcgggc cggggcctgg    780

tctcggtctc cgcggagcgc ccctgaccac cgcgacgggc ggctgcggtg gtggtggcgc    840

aggaagggga ggcctcggga agccacacag tgggacaggg atcccggagc gaggaaggcc    900

ccctccgtcc agctggagcc cttgccggcg tggcggcagt gcagtccgtg gctgcgcggg    960

aaagccggct gtggcggagg cgcgggctgg ggaccctgcg cgccggggtg gcccacgggc   1020

agcggcgtaa gcaaagcggt gggcgggccc tgcgggcgcg aggctgccct aggcagccac   1080

cagatcttgg acttccccgc gtggctcacc ctgcaggccg cccgctgcag cgctggggct   1140

aaccggcgcc tgcagccagg ctctgggacc tccttggcca gacccaagag cgagccttgg   1200

ggttga                                                              1206


<210>  3082
<211>  401
<212>  PRT
<213>  Homosapiens

<400>  3082

Met Arg Leu Pro Gln His Lys Arg Ala Leu Arg Ala Gly His Thr Gln 
1               5                   10                  15      


Arg Glu Ala Gln Ser Ala Leu Lys Gly Gly Gly Ser Gly Ala Ala Gly 
            20                  25                  30          


Ala Val Gln His Ala Pro Lys Pro Val Pro Ser Pro Gly Arg Lys Pro 
        35                  40                  45              


Thr Ala Pro Thr Gly Arg Leu Arg Ala Ala Arg Ala Ala Phe Thr Ala 
    50                  55                  60                  


Ala Arg Arg Ile Gln Pro Trp Asp Glu Ala Pro Leu Gly Lys Glu Ser 
65                  70                  75                  80  


Glu Glu Val Gln Cys Trp Asp Gly Gly His Val Val Gly Ala Pro Arg 
                85                  90                  95      


Gly Ser Gly Leu Leu Ser Pro Pro Pro Arg Ser Pro His Ala Gln Ala 
            100                 105                 110         


Gly Pro Arg Val Glu Arg Ser Ser Leu Gly Glu His Glu Gly Leu Arg 
        115                 120                 125             


Leu Ala Leu Gln Ile Gln Glu Gly Glu Asp Pro Gly Leu Glu Ala Thr 
    130                 135                 140                 


Ala Ala Arg Pro Ser Leu Pro Met Met Ile Leu Thr Thr Val Pro Thr 
145                 150                 155                 160 


Thr Phe Ala Asn Ala Arg Arg Pro Leu Lys Glu Asn Ala Val Thr Trp 
                165                 170                 175     


Gly Ala His Ser Lys Asp Gln Glu Asp Gly Gly Leu Phe Ser Ser Asp 
            180                 185                 190         


Thr Glu Gly Asp Pro Glu Lys Ala Glu Ile Asp Pro Glu Glu His Pro 
        195                 200                 205             


Ser Pro Gln Asp Gln His Ala Pro Trp Arg Pro Gln Pro Ile Leu Pro 
    210                 215                 220                 


Ala His Pro His Thr Ser Pro Gly Leu Ser Asn Leu Ser Arg Gly Pro 
225                 230                 235                 240 


Ser Glu Leu Gly Ile Arg Ser Cys Ala Trp Glu Arg Ala Glu Leu Arg 
                245                 250                 255     


Ala Gly Ala Trp Ser Arg Ser Pro Arg Ser Ala Pro Asp His Arg Asp 
            260                 265                 270         


Gly Arg Leu Arg Trp Trp Trp Arg Arg Lys Gly Arg Pro Arg Glu Ala 
        275                 280                 285             


Thr Gln Trp Asp Arg Asp Pro Gly Ala Arg Lys Ala Pro Ser Val Gln 
    290                 295                 300                 


Leu Glu Pro Leu Pro Ala Trp Arg Gln Cys Ser Pro Trp Leu Arg Gly 
305                 310                 315                 320 


Lys Ala Gly Cys Gly Gly Gly Ala Gly Trp Gly Pro Cys Ala Pro Gly 
                325                 330                 335     


Trp Pro Thr Gly Ser Gly Val Ser Lys Ala Val Gly Gly Pro Cys Gly 
            340                 345                 350         


Arg Glu Ala Ala Leu Gly Ser His Gln Ile Leu Asp Phe Pro Ala Trp 
        355                 360                 365             


Leu Thr Leu Gln Ala Ala Arg Cys Ser Ala Gly Ala Asn Arg Arg Leu 
    370                 375                 380                 


Gln Pro Gly Ser Gly Thr Ser Leu Ala Arg Pro Lys Ser Glu Pro Trp 
385                 390                 395                 400 


Gly 
    


<210>  3083
<211>  1206
<212>  DNA
<213>  Homosapiens

<400>  3083
atgcgtttac cgcagcataa acgcgcactg cgagctggcc atacccagcg agaggcgcag     60

agtgcgctga aggggggcgg gagcggcgcc gcgggcgcgg tccagcatgc ccccaagccc    120

gttccctccc cggggcgaaa gccaacagca cccactggtc gcctgcgggc tgcgagggcg    180

gctttcaccg ctgcgcggcg catccagcct tgggacgagg cccctctcgg caaggaatct    240

gaagaggtcc agtgttggga cgggggacac gtggtagggg cgcccagggg ctcaggtctc    300

ctgtccccgc ctccccgctc tccccacgcg caggcaggcc cgcgggtgga gcgcagctct    360

ctgggagagc acgagggcct tcgcctggct ttgcaaattc aggaaggaga agacccaggg    420

ctcgaggcca ctgccgcgcg cccttccctg cccatgatga tcctcacgac agtccccacc    480

accttcgcca acgcccgccg gcccctcaag gagaacgcgg tgacgtgggg agcgcacagc    540

aaggaccagg aggacggagg ccttttcagc agcgacactg agggcgaccc cgagaaggca    600

gagattgacc cggaggagca tccatctcca caagaccaac acgcaccatg gcgaccacag    660

cccattctcc ctgcgcaccc ccacacctcg ccaggcctct ctaatctcag ccggggtcca    720

agtgaacttg gcatcaggag ctgcgcctgg gaacgcgcgg agctgcgggc cggggcctgg    780

tctcggtctc cgcggagcgc ccctgaccac cgcgacgggc ggctgcggtg gtggtggcgc    840

aggaagggga ggcctcggga agccacacag tgggagaggg atcccggagc gaggaaggcc    900

ccctccgtcc agctggagcc cttgccggcg tggcggcagt gcagtccgtg gctgcgcggg    960

aaagccggct gtggcggagg cgcgggctgg ggaccctgcg cgccggggtg gcccacgggc   1020

agcggcgtaa gcaaagcggt gggcgggccc tgcgggcgcg aggctgccct aggcagccac   1080

cagatcttgg acttccccgc gtggctcacc ctgcaggccg cccgctgcag cgctggggct   1140

aaccggcgcc tgcagccagg ctctgggacc tccttggcca gacccaagag cgagccttgg   1200

ggttga                                                              1206


<210>  3084
<211>  401
<212>  PRT
<213>  Homosapiens

<400>  3084

Met Arg Leu Pro Gln His Lys Arg Ala Leu Arg Ala Gly His Thr Gln 
1               5                   10                  15      


Arg Glu Ala Gln Ser Ala Leu Lys Gly Gly Gly Ser Gly Ala Ala Gly 
            20                  25                  30          


Ala Val Gln His Ala Pro Lys Pro Val Pro Ser Pro Gly Arg Lys Pro 
        35                  40                  45              


Thr Ala Pro Thr Gly Arg Leu Arg Ala Ala Arg Ala Ala Phe Thr Ala 
    50                  55                  60                  


Ala Arg Arg Ile Gln Pro Trp Asp Glu Ala Pro Leu Gly Lys Glu Ser 
65                  70                  75                  80  


Glu Glu Val Gln Cys Trp Asp Gly Gly His Val Val Gly Ala Pro Arg 
                85                  90                  95      


Gly Ser Gly Leu Leu Ser Pro Pro Pro Arg Ser Pro His Ala Gln Ala 
            100                 105                 110         


Gly Pro Arg Val Glu Arg Ser Ser Leu Gly Glu His Glu Gly Leu Arg 
        115                 120                 125             


Leu Ala Leu Gln Ile Gln Glu Gly Glu Asp Pro Gly Leu Glu Ala Thr 
    130                 135                 140                 


Ala Ala Arg Pro Ser Leu Pro Met Met Ile Leu Thr Thr Val Pro Thr 
145                 150                 155                 160 


Thr Phe Ala Asn Ala Arg Arg Pro Leu Lys Glu Asn Ala Val Thr Trp 
                165                 170                 175     


Gly Ala His Ser Lys Asp Gln Glu Asp Gly Gly Leu Phe Ser Ser Asp 
            180                 185                 190         


Thr Glu Gly Asp Pro Glu Lys Ala Glu Ile Asp Pro Glu Glu His Pro 
        195                 200                 205             


Ser Pro Gln Asp Gln His Ala Pro Trp Arg Pro Gln Pro Ile Leu Pro 
    210                 215                 220                 


Ala His Pro His Thr Ser Pro Gly Leu Ser Asn Leu Ser Arg Gly Pro 
225                 230                 235                 240 


Ser Glu Leu Gly Ile Arg Ser Cys Ala Trp Glu Arg Ala Glu Leu Arg 
                245                 250                 255     


Ala Gly Ala Trp Ser Arg Ser Pro Arg Ser Ala Pro Asp His Arg Asp 
            260                 265                 270         


Gly Arg Leu Arg Trp Trp Trp Arg Arg Lys Gly Arg Pro Arg Glu Ala 
        275                 280                 285             


Thr Gln Trp Glu Arg Asp Pro Gly Ala Arg Lys Ala Pro Ser Val Gln 
    290                 295                 300                 


Leu Glu Pro Leu Pro Ala Trp Arg Gln Cys Ser Pro Trp Leu Arg Gly 
305                 310                 315                 320 


Lys Ala Gly Cys Gly Gly Gly Ala Gly Trp Gly Pro Cys Ala Pro Gly 
                325                 330                 335     


Trp Pro Thr Gly Ser Gly Val Ser Lys Ala Val Gly Gly Pro Cys Gly 
            340                 345                 350         


Arg Glu Ala Ala Leu Gly Ser His Gln Ile Leu Asp Phe Pro Ala Trp 
        355                 360                 365             


Leu Thr Leu Gln Ala Ala Arg Cys Ser Ala Gly Ala Asn Arg Arg Leu 
    370                 375                 380                 


Gln Pro Gly Ser Gly Thr Ser Leu Ala Arg Pro Lys Ser Glu Pro Trp 
385                 390                 395                 400 


Gly 
    


<210>  3085
<211>  5120
<212>  DNA
<213>  Homosapiens

<400>  3085
ggactcgcac tcggcggttg ttccagaaga aagagacagc gatggcggca gaggcttcga     60

agactgggcc ttctaggtct tcctaccagc gaatggggag gaagagtcag ccctggggtg    120

ccgctgaaat ccagtgcacc aggtgtggaa ggagggtatc cagatcatcc ggtcaccatt    180

gtgaacttca atgtggacat gctttttgtg aactatgctt gttaatgact gaagaatgca    240

ccacaattat atgccctgat tgtgaggttg ctacagctgt aaatactaga caacgctact    300

acccaatggc tggatatatt aaggaagact ccataatgga aaaactgcag cctaagacga    360

taaagaattg ttctcaggac tttaagaaga ctgctgatca gctaactact ggtttagaac    420

gttcagcctc cacagacaag actcttttga actcatcagc tgtaatgttg gacactaata    480

ctgcagaaga aattgatgaa gcattgaata cagcacacca tagtttcgaa cagttaagca    540

ttgctggaaa agcacttgaa cacatgcaga agcaaacgat agaggaaaga gaaagagtta    600

tagaagttgt ggagaaacag tttgaccaac ttttggcttt ttttgattcc aggaaaaaga    660

acctgtgtga agaatttgca agaactactg atgattatct atcaaattta ataaaggcta    720

aaagctacat tgaagagaaa aaaaataatt tgaatgcagc tatgaacata gcaagagcat    780

tacaattatc gccttctcta agaacatact gtgacctgaa tcagattatc cggactttgc    840

agttaacttc agatagtgaa ttagcacaag ttagttctcc acaactaagg aaccctccca    900

ggttgagtgt gaattgcagt gagatcatct gtatgttcaa caatatggga aagattgaat    960

ttagggactc aacaaaatgt tatccccaag aaaatgaaat tagacagaat gttcaaaaga   1020

aatataataa caaaaaggaa ctttcttgtt acgatacata cccaccgcta gaaaagaaaa   1080

aggttgacat gtctgtccta accagtgaag caccaccacc tcctttgcaa cctgagacaa   1140

atgatgtaca tttagaagca aaaaacttcc agccacagaa agacgttgca acagcatccc   1200

ctaaaaccat tgctgtgtta cctcagatgg gatctagccc tgatgtgata attgaagaaa   1260

ttattgaaga caacgtggaa agttctgcag agctagtttt tgtaagccat gtaatagatc   1320

cttgccattt ctacattcgg aagtattcac aaataaaaga cgccaaagta ctggagaaga   1380

aggtgaatga attttgcaat aggagttcac accttgatcc ttcagacatt ttggaactag   1440

gtgcaagaat atttgtcagc agtattaaaa atggaatgtg gtgtcgagga actatcacag   1500

aattaattcc aatagagggt agaaatacca gaaaaccttg tagtccaacc agattatttg   1560

tccatgaagt tgcactaata caaatattca tggtagattt tggaaattct gaagtcctga   1620

ttgtcactgg agttgttgat acccatgtga gaccagaaca ctctgctaag caacatattg   1680

cactaaatga tttatgtctg gttctaagga aatctgaacc atatactgaa gggctgctaa   1740

aagacatcca gccattagca caaccatgct cattgaaaga cattgttcca cagaattcaa   1800

atgaaggctg ggaagaggaa gctaaagtgg aatttttgaa aatggtaaat aacaaggctg   1860

tttcaatgaa agtttttaga gaagaagatg gtgtgcttat tgtagatctg caaaaaccac   1920

caccgaataa aataagcagt gatatgcctg tgtctcttag agatgcgcta gtttttatgg   1980

aactagcaaa gtttaagtca caatcactaa gaagtcactt tgaaaaaaat actactttac   2040

actatcatcc acctattttg cctaaagaaa tgacagatgt ttcagtaacg gtttgtcata   2100

taaatagtcc tggagatttc tatcttcagt tgatagaggg cctggatatt ttatttctat   2160

taaagacaat cgaggaattc tataaaagtg aagatggaga aaatctggaa atcctctgtc   2220

cagttcaaga tcaagcctgt gtagctaaat ttgaagatgg aatttggtac cgagcaaaag   2280

ttatcggatt gcctggacat caggaagttg aagttaaata tgtggacttt ggtaatactg   2340

caaaaataac aatcaaagac gtgcgtaaaa taaaggatga gtttctgaat gccccagaga   2400

aggcaattaa atgtaagttg gcctatattg aaccatataa aaggacaatg cagtggtcca   2460

aagaagctaa agaaaaattt gaagaaaagg ctcaagataa atttatgaca tgttcagtta   2520

tcaaaattct ggaagataat gtgctcttag ttgagctttt cgattctctt ggtgctcctg   2580

aaatgactac tactagtatt aatgaccagc tagttaaaga gggcctagca tcttatgaaa   2640

taggatacat cctcaaagat aattctcaaa agcatattga agtttgggat ccttctccag   2700

aagaaattat ttcaaatgaa gtacacaact taaatcctgt gtctgcaaaa tctctaccta   2760

atgagaattt tcagtcactt tataataagg aattgcctgt gcatatctgt aatgtaatat   2820

ctcctgagaa gatttatgtt cagtggttgt taactgaaaa cttacttaat agtttagaag   2880

aaaagatgat agctgcttat gaaaactcaa aatgggaacc tgttaaatgg gaaaatgata   2940

tgcactgtgc tgttaagatc caagataaaa atcagtggcg aagaggccag atcatcagaa   3000

tggttacaga cacattggta gaggtcttgc tgtatgatgt gggtgttgaa ctagtagtga   3060

atgttgactg tttaagaaaa cttgaagaaa atctaaagac aatgggaaga ctctctttgg   3120

aatgttctct ggttgacata agaccagctg gtgggagtga caagtggaca gcaacagctt   3180

gtgactgtct ttcattgtac ctgactggag ctgtagcaac tataatctta caggtggata   3240

gtgaggaaaa caacacaaca tggccattac ctgtgaaaat tttctgcaga gatgaaaaag   3300

gagagcgtgt tgatgtttct aaatatttga ttaaaaaggg tttggctttg agagaaagga   3360

gaattaataa cttagataac agccattcat tatctgagaa gtctctggaa gtccccctgg   3420

aacaggaaga ttcagtagtt actaactgta ttaaaactaa ctttgaccct gacaagaaaa   3480

ctgctgacat aatcagtgaa cagaaagtgt ctgaatttca ggagaaaatt ctagaaccaa   3540

gaaccactag agggtataag ccaccagcta ttcctaacat gaacgtattt gaggcaacag   3600

tcagctgtgt tggtgatgat ggaactatat ttgtagtacc taaactatca gaatttgagc   3660

taataaaaat gacaaatgaa attcaaagta atttaaaatg ccttggtctt ttggagcctt   3720

atttctggaa aaaaggagaa gcatgtgcag taagaggatc cgatactctg tggtatcgtg   3780

gcaaggtgat ggaggttgta ggtggcgctg tcagagtaca atatttagat catggattca   3840

ctgaaaagat tccgcagtgc catctttacc ctattttgct gtatcctgat ataccccagt   3900

tttgtattcc ttgtcagctc cataatacca cacctgttgg gaatgtctgg caaccagatg   3960

caatagaagt tcttcaacaa ctgctttcaa agagacaggt ggacattcac attatggagt   4020

tacctaaaaa tccatgggag aaattgtcta ttcacctcta ttttgatgga atgtcacttt   4080

cttattttat ggcatactat aaatactgta cttctgaaca tactgaggag atgttgaaag   4140

aaaaaccaag atcagatcat gataaaaagt atgaagagga acaatgggaa ataaggtttg   4200

aggaattgct ttcggctgaa acagacactc ctcttttacc accatatttg tcttcatctc   4260

tgccttcccc aggagaactc tatgctgttc aagttaagca cgttgtctca cctaatgaag   4320

tgtatatttg ccttgattct atagaaactt ctaaccagtc taaccagcat agtgacacag   4380

atgatagtgg agtcagcggg gaatcagaat ccgagagcct tgatgaagca ctgcagaggg   4440

ttaataagaa ggtagaggcg cttcctcctc tgacggattt tagaacagaa atgccttgcc   4500

ttgcagaata tgatgatggc ttatggtata gagcgaagat tgttgccatt aaagaattta   4560

atcctttatc tatcttagta caatttgttg attatggatc aactgcaaag ctgacattaa   4620

acagactgtg ccaaattcct tctcatctta tgcggtatcc agctcgagcc ataaaggttc   4680

tcttggcagg gtttaaacct cccttaaggg atctagggga gacaagaata ccatattgtc   4740

ccaaatggag catggaggca ctgtgggcta tgatagactg tcttcaagga aaacaactct   4800

atgctgtgtc catggctcca gcaccagaac agatagtgac attatatgac gatgaacagc   4860

atccagttca tatgccgttg gtagaaatgg ggcttgcaga taaagatgaa taagtgccta   4920

agtgtataca gtgagagcat ctatagaagc ctagaagaat tctgttatgt ttagactatg   4980

tcttatcttt agactatttc aggcttaatt ttcctaactt gttcagcact agtgctttac   5040

ctctcatttt taattgaact gttaggaatt gtgtggggaa aaaaagtaaa taaatgttcg   5100

cttccaaaaa aaaaaaaaaa                                               5120


<210>  3086
<211>  1623
<212>  PRT
<213>  Homosapiens

<400>  3086

Met Ala Ala Glu Ala Ser Lys Thr Gly Pro Ser Arg Ser Ser Tyr Gln 
1               5                   10                  15      


Arg Met Gly Arg Lys Ser Gln Pro Trp Gly Ala Ala Glu Ile Gln Cys 
            20                  25                  30          


Thr Arg Cys Gly Arg Arg Val Ser Arg Ser Ser Gly His His Cys Glu 
        35                  40                  45              


Leu Gln Cys Gly His Ala Phe Cys Glu Leu Cys Leu Leu Met Thr Glu 
    50                  55                  60                  


Glu Cys Thr Thr Ile Ile Cys Pro Asp Cys Glu Val Ala Thr Ala Val 
65                  70                  75                  80  


Asn Thr Arg Gln Arg Tyr Tyr Pro Met Ala Gly Tyr Ile Lys Glu Asp 
                85                  90                  95      


Ser Ile Met Glu Lys Leu Gln Pro Lys Thr Ile Lys Asn Cys Ser Gln 
            100                 105                 110         


Asp Phe Lys Lys Thr Ala Asp Gln Leu Thr Thr Gly Leu Glu Arg Ser 
        115                 120                 125             


Ala Ser Thr Asp Lys Thr Leu Leu Asn Ser Ser Ala Val Met Leu Asp 
    130                 135                 140                 


Thr Asn Thr Ala Glu Glu Ile Asp Glu Ala Leu Asn Thr Ala His His 
145                 150                 155                 160 


Ser Phe Glu Gln Leu Ser Ile Ala Gly Lys Ala Leu Glu His Met Gln 
                165                 170                 175     


Lys Gln Thr Ile Glu Glu Arg Glu Arg Val Ile Glu Val Val Glu Lys 
            180                 185                 190         


Gln Phe Asp Gln Leu Leu Ala Phe Phe Asp Ser Arg Lys Lys Asn Leu 
        195                 200                 205             


Cys Glu Glu Phe Ala Arg Thr Thr Asp Asp Tyr Leu Ser Asn Leu Ile 
    210                 215                 220                 


Lys Ala Lys Ser Tyr Ile Glu Glu Lys Lys Asn Asn Leu Asn Ala Ala 
225                 230                 235                 240 


Met Asn Ile Ala Arg Ala Leu Gln Leu Ser Pro Ser Leu Arg Thr Tyr 
                245                 250                 255     


Cys Asp Leu Asn Gln Ile Ile Arg Thr Leu Gln Leu Thr Ser Asp Ser 
            260                 265                 270         


Glu Leu Ala Gln Val Ser Ser Pro Gln Leu Arg Asn Pro Pro Arg Leu 
        275                 280                 285             


Ser Val Asn Cys Ser Glu Ile Ile Cys Met Phe Asn Asn Met Gly Lys 
    290                 295                 300                 


Ile Glu Phe Arg Asp Ser Thr Lys Cys Tyr Pro Gln Glu Asn Glu Ile 
305                 310                 315                 320 


Arg Gln Asn Val Gln Lys Lys Tyr Asn Asn Lys Lys Glu Leu Ser Cys 
                325                 330                 335     


Tyr Asp Thr Tyr Pro Pro Leu Glu Lys Lys Lys Val Asp Met Ser Val 
            340                 345                 350         


Leu Thr Ser Glu Ala Pro Pro Pro Pro Leu Gln Pro Glu Thr Asn Asp 
        355                 360                 365             


Val His Leu Glu Ala Lys Asn Phe Gln Pro Gln Lys Asp Val Ala Thr 
    370                 375                 380                 


Ala Ser Pro Lys Thr Ile Ala Val Leu Pro Gln Met Gly Ser Ser Pro 
385                 390                 395                 400 


Asp Val Ile Ile Glu Glu Ile Ile Glu Asp Asn Val Glu Ser Ser Ala 
                405                 410                 415     


Glu Leu Val Phe Val Ser His Val Ile Asp Pro Cys His Phe Tyr Ile 
            420                 425                 430         


Arg Lys Tyr Ser Gln Ile Lys Asp Ala Lys Val Leu Glu Lys Lys Val 
        435                 440                 445             


Asn Glu Phe Cys Asn Arg Ser Ser His Leu Asp Pro Ser Asp Ile Leu 
    450                 455                 460                 


Glu Leu Gly Ala Arg Ile Phe Val Ser Ser Ile Lys Asn Gly Met Trp 
465                 470                 475                 480 


Cys Arg Gly Thr Ile Thr Glu Leu Ile Pro Ile Glu Gly Arg Asn Thr 
                485                 490                 495     


Arg Lys Pro Cys Ser Pro Thr Arg Leu Phe Val His Glu Val Ala Leu 
            500                 505                 510         


Ile Gln Ile Phe Met Val Asp Phe Gly Asn Ser Glu Val Leu Ile Val 
        515                 520                 525             


Thr Gly Val Val Asp Thr His Val Arg Pro Glu His Ser Ala Lys Gln 
    530                 535                 540                 


His Ile Ala Leu Asn Asp Leu Cys Leu Val Leu Arg Lys Ser Glu Pro 
545                 550                 555                 560 


Tyr Thr Glu Gly Leu Leu Lys Asp Ile Gln Pro Leu Ala Gln Pro Cys 
                565                 570                 575     


Ser Leu Lys Asp Ile Val Pro Gln Asn Ser Asn Glu Gly Trp Glu Glu 
            580                 585                 590         


Glu Ala Lys Val Glu Phe Leu Lys Met Val Asn Asn Lys Ala Val Ser 
        595                 600                 605             


Met Lys Val Phe Arg Glu Glu Asp Gly Val Leu Ile Val Asp Leu Gln 
    610                 615                 620                 


Lys Pro Pro Pro Asn Lys Ile Ser Ser Asp Met Pro Val Ser Leu Arg 
625                 630                 635                 640 


Asp Ala Leu Val Phe Met Glu Leu Ala Lys Phe Lys Ser Gln Ser Leu 
                645                 650                 655     


Arg Ser His Phe Glu Lys Asn Thr Thr Leu His Tyr His Pro Pro Ile 
            660                 665                 670         


Leu Pro Lys Glu Met Thr Asp Val Ser Val Thr Val Cys His Ile Asn 
        675                 680                 685             


Ser Pro Gly Asp Phe Tyr Leu Gln Leu Ile Glu Gly Leu Asp Ile Leu 
    690                 695                 700                 


Phe Leu Leu Lys Thr Ile Glu Glu Phe Tyr Lys Ser Glu Asp Gly Glu 
705                 710                 715                 720 


Asn Leu Glu Ile Leu Cys Pro Val Gln Asp Gln Ala Cys Val Ala Lys 
                725                 730                 735     


Phe Glu Asp Gly Ile Trp Tyr Arg Ala Lys Val Ile Gly Leu Pro Gly 
            740                 745                 750         


His Gln Glu Val Glu Val Lys Tyr Val Asp Phe Gly Asn Thr Ala Lys 
        755                 760                 765             


Ile Thr Ile Lys Asp Val Arg Lys Ile Lys Asp Glu Phe Leu Asn Ala 
    770                 775                 780                 


Pro Glu Lys Ala Ile Lys Cys Lys Leu Ala Tyr Ile Glu Pro Tyr Lys 
785                 790                 795                 800 


Arg Thr Met Gln Trp Ser Lys Glu Ala Lys Glu Lys Phe Glu Glu Lys 
                805                 810                 815     


Ala Gln Asp Lys Phe Met Thr Cys Ser Val Ile Lys Ile Leu Glu Asp 
            820                 825                 830         


Asn Val Leu Leu Val Glu Leu Phe Asp Ser Leu Gly Ala Pro Glu Met 
        835                 840                 845             


Thr Thr Thr Ser Ile Asn Asp Gln Leu Val Lys Glu Gly Leu Ala Ser 
    850                 855                 860                 


Tyr Glu Ile Gly Tyr Ile Leu Lys Asp Asn Ser Gln Lys His Ile Glu 
865                 870                 875                 880 


Val Trp Asp Pro Ser Pro Glu Glu Ile Ile Ser Asn Glu Val His Asn 
                885                 890                 895     


Leu Asn Pro Val Ser Ala Lys Ser Leu Pro Asn Glu Asn Phe Gln Ser 
            900                 905                 910         


Leu Tyr Asn Lys Glu Leu Pro Val His Ile Cys Asn Val Ile Ser Pro 
        915                 920                 925             


Glu Lys Ile Tyr Val Gln Trp Leu Leu Thr Glu Asn Leu Leu Asn Ser 
    930                 935                 940                 


Leu Glu Glu Lys Met Ile Ala Ala Tyr Glu Asn Ser Lys Trp Glu Pro 
945                 950                 955                 960 


Val Lys Trp Glu Asn Asp Met His Cys Ala Val Lys Ile Gln Asp Lys 
                965                 970                 975     


Asn Gln Trp Arg Arg Gly Gln Ile Ile Arg Met Val Thr Asp Thr Leu 
            980                 985                 990         


Val Glu Val Leu Leu Tyr Asp Val  Gly Val Glu Leu Val  Val Asn Val 
        995                 1000                 1005             


Asp Cys  Leu Arg Lys Leu Glu  Glu Asn Leu Lys Thr  Met Gly Arg 
    1010                 1015                 1020             


Leu Ser  Leu Glu Cys Ser Leu  Val Asp Ile Arg Pro  Ala Gly Gly 
    1025                 1030                 1035             


Ser Asp  Lys Trp Thr Ala Thr  Ala Cys Asp Cys Leu  Ser Leu Tyr 
    1040                 1045                 1050             


Leu Thr  Gly Ala Val Ala Thr  Ile Ile Leu Gln Val  Asp Ser Glu 
    1055                 1060                 1065             


Glu Asn  Asn Thr Thr Trp Pro  Leu Pro Val Lys Ile  Phe Cys Arg 
    1070                 1075                 1080             


Asp Glu  Lys Gly Glu Arg Val  Asp Val Ser Lys Tyr  Leu Ile Lys 
    1085                 1090                 1095             


Lys Gly  Leu Ala Leu Arg Glu  Arg Arg Ile Asn Asn  Leu Asp Asn 
    1100                 1105                 1110             


Ser His  Ser Leu Ser Glu Lys  Ser Leu Glu Val Pro  Leu Glu Gln 
    1115                 1120                 1125             


Glu Asp  Ser Val Val Thr Asn  Cys Ile Lys Thr Asn  Phe Asp Pro 
    1130                 1135                 1140             


Asp Lys  Lys Thr Ala Asp Ile  Ile Ser Glu Gln Lys  Val Ser Glu 
    1145                 1150                 1155             


Phe Gln  Glu Lys Ile Leu Glu  Pro Arg Thr Thr Arg  Gly Tyr Lys 
    1160                 1165                 1170             


Pro Pro  Ala Ile Pro Asn Met  Asn Val Phe Glu Ala  Thr Val Ser 
    1175                 1180                 1185             


Cys Val  Gly Asp Asp Gly Thr  Ile Phe Val Val Pro  Lys Leu Ser 
    1190                 1195                 1200             


Glu Phe  Glu Leu Ile Lys Met  Thr Asn Glu Ile Gln  Ser Asn Leu 
    1205                 1210                 1215             


Lys Cys  Leu Gly Leu Leu Glu  Pro Tyr Phe Trp Lys  Lys Gly Glu 
    1220                 1225                 1230             


Ala Cys  Ala Val Arg Gly Ser  Asp Thr Leu Trp Tyr  Arg Gly Lys 
    1235                 1240                 1245             


Val Met  Glu Val Val Gly Gly  Ala Val Arg Val Gln  Tyr Leu Asp 
    1250                 1255                 1260             


His Gly  Phe Thr Glu Lys Ile  Pro Gln Cys His Leu  Tyr Pro Ile 
    1265                 1270                 1275             


Leu Leu  Tyr Pro Asp Ile Pro  Gln Phe Cys Ile Pro  Cys Gln Leu 
    1280                 1285                 1290             


His Asn  Thr Thr Pro Val Gly  Asn Val Trp Gln Pro  Asp Ala Ile 
    1295                 1300                 1305             


Glu Val  Leu Gln Gln Leu Leu  Ser Lys Arg Gln Val  Asp Ile His 
    1310                 1315                 1320             


Ile Met  Glu Leu Pro Lys Asn  Pro Trp Glu Lys Leu  Ser Ile His 
    1325                 1330                 1335             


Leu Tyr  Phe Asp Gly Met Ser  Leu Ser Tyr Phe Met  Ala Tyr Tyr 
    1340                 1345                 1350             


Lys Tyr  Cys Thr Ser Glu His  Thr Glu Glu Met Leu  Lys Glu Lys 
    1355                 1360                 1365             


Pro Arg  Ser Asp His Asp Lys  Lys Tyr Glu Glu Glu  Gln Trp Glu 
    1370                 1375                 1380             


Ile Arg  Phe Glu Glu Leu Leu  Ser Ala Glu Thr Asp  Thr Pro Leu 
    1385                 1390                 1395             


Leu Pro  Pro Tyr Leu Ser Ser  Ser Leu Pro Ser Pro  Gly Glu Leu 
    1400                 1405                 1410             


Tyr Ala  Val Gln Val Lys His  Val Val Ser Pro Asn  Glu Val Tyr 
    1415                 1420                 1425             


Ile Cys  Leu Asp Ser Ile Glu  Thr Ser Asn Gln Ser  Asn Gln His 
    1430                 1435                 1440             


Ser Asp  Thr Asp Asp Ser Gly  Val Ser Gly Glu Ser  Glu Ser Glu 
    1445                 1450                 1455             


Ser Leu  Asp Glu Ala Leu Gln  Arg Val Asn Lys Lys  Val Glu Ala 
    1460                 1465                 1470             


Leu Pro  Pro Leu Thr Asp Phe  Arg Thr Glu Met Pro  Cys Leu Ala 
    1475                 1480                 1485             


Glu Tyr  Asp Asp Gly Leu Trp  Tyr Arg Ala Lys Ile  Val Ala Ile 
    1490                 1495                 1500             


Lys Glu  Phe Asn Pro Leu Ser  Ile Leu Val Gln Phe  Val Asp Tyr 
    1505                 1510                 1515             


Gly Ser  Thr Ala Lys Leu Thr  Leu Asn Arg Leu Cys  Gln Ile Pro 
    1520                 1525                 1530             


Ser His  Leu Met Arg Tyr Pro  Ala Arg Ala Ile Lys  Val Leu Leu 
    1535                 1540                 1545             


Ala Gly  Phe Lys Pro Pro Leu  Arg Asp Leu Gly Glu  Thr Arg Ile 
    1550                 1555                 1560             


Pro Tyr  Cys Pro Lys Trp Ser  Met Glu Ala Leu Trp  Ala Met Ile 
    1565                 1570                 1575             


Asp Cys  Leu Gln Gly Lys Gln  Leu Tyr Ala Val Ser  Met Ala Pro 
    1580                 1585                 1590             


Ala Pro  Glu Gln Ile Val Thr  Leu Tyr Asp Asp Glu  Gln His Pro 
    1595                 1600                 1605             


Val His  Met Pro Leu Val Glu  Met Gly Leu Ala Asp  Lys Asp Glu 
    1610                 1615                 1620             


<210>  3087
<211>  4387
<212>  DNA
<213>  Homosapiens

<400>  3087
cggcccgagg tcctgtggga agtgaggatc tcaggacggg ggcggggctc cgacagaggc     60

ggcgattgtg gcggcccatt tgtaaatgct gcggagattg aggtgtcggt tcgtgctgct    120

gagctgccca ggcttcacgg agcggtgttg gtaatcaata gctcttctag cctttgcatt    180

gtttaaatat aatagtgtca ttggactaag atgttcctga tgccaacctc ttcagagtta    240

aacagtgggc agaacttcct aacccagtgg atgaccaatc cttctcgggc tggggtcata    300

ttaaatcgtg gatttcctat tttggaagca gacaaagaga agcgagcagc tgtggacatt    360

tctaccagct ttcctattaa aggcacacat ttttctgata gcttcagctt tataaatgaa    420

gaagattcac ttcttgaaga acagaagttg gagtcaaaca acccttacaa accacagtca    480

gataaatctg aaacccatac agcctttcct tgcattaaaa agggaccaca ggtagcggca    540

tgtcacagtg ctcctggaca ccaggaagaa aacaaaaatg acttcatccc agatcgtgcg    600

agtgaattca aagaaggggc ttataaagac ccacttttta aaaaacttga acagctgaaa    660

gaagtacaac agaagaagca ggaacaattg aagaggcaac agttggagca actacagaga    720

ctcatggaag aacaagagaa gctgctcacc atggtgtctg ggcagtgcac acttccaggt    780

ttgagtttac tgcctgatga tcagagccag aagcacaggt ctccaggaaa taccaccact    840

ggagagagag ccacatgctg cttcccatca tatgtctacc cggacccaac ccaggaagaa    900

acatacccgt ccaacatttt atcccatgag caaagcaact tctgtagaac tgctcatgga    960

gattttgtct taacttcaaa acgtgcgtct cctaatttat tttctgaggc acagtatcaa   1020

gaagcacctg tggaaaaaaa taatttaaaa gaagaaaacc gtaaccatcc tacaggagaa   1080

agtatcttat gttgggagaa agtgacagaa cagattcagg aagcaaatga taagaactta   1140

caaaaacatg atgattcctc agaagtggct aatattgaag aaaggcccat taaagctgct   1200

attggagaaa ggaaacagac ctttgaagat tacttagaag aacaaattca gttggaagag   1260

caagaactga agcaaaaaca gctgaaggaa gcagaaggac cattgccaat caaagcaaaa   1320

ccaaaacaac catttttaaa acgaggagaa ggtttagcta gatttactaa tgccaaatct   1380

aagtttcaaa aaggcaaaga aagtaaacta gtgactaacc agagcacttc cgaggaccag   1440

ccgctgttta aaatggatag acagcaactc cagcggaaaa ccgctcttaa aaataaagag   1500

ctgtgtgcag acaaccctat ccttaaaaag gacagtaaag ctagaaccaa gagtggttct   1560

gtcaccctca gtcagaagcc gaaaatgctg aagtgtagta acaggaaaag tctttctccg   1620

tcaggattga aaatacagac ggggaagaaa tgtgatgggc agtttagaga ccagatcaaa   1680

tttgaaaaca aagtcacatc taataataaa gaaaatgtaa ctgagtgtcc aaaaccttgc   1740

gatactggct gcacagggtg gaataagaca caaggtaaag acagacttcc tctttcaaca   1800

gggccggcca gccggctggc tgctaagagc cccataaggg agaccatgaa agagtctgaa   1860

tcttctcttg acgtttctct tcagaaaaag ttagagactt gggaacgaga aaaggaaaag   1920

gaaaatttgg aattagatga atttttgttt ttagaacaag ctgctgatga aatatcattt   1980

tctagtaatt cctcatttgt actgaaaatc ttagaaaggg atcaacagat ctgcaaaggt   2040

caccggatgt cttccacccc tgtcaaagct gtgccacaga agacaaatcc ggcagatccc   2100

attagtcatt gtaaccgcag tgaggatttg gaccacactg cacgtgagaa ggagagtgag   2160

tgtgaagtcg cacccaaaca acttcattca ttgtcctcag ctgatgaatt gagggaacag   2220

ccttgtaaaa tcaggaaagc cgtccaaaag agcacttctg aaaatcagac tgaatggaat   2280

gcacgtgacg atgaaggtgt tccaaatagt gacagtagca ctgactctga ggaacagctt   2340

gatgttacca taaaaccatc gactgaggat agagagaggg gcatcagcag cagagaggat   2400

agcccacaag tctgtgatga taaggggcct tttaaggaca ccaggaccca agaagataaa   2460

aggagagatg ttgatctgga tttgtctgat aaagattaca gtagcgatga gtctatcatg   2520

gaaagcataa aacataaagt gtctgagccc tcgagatcct catccctaag tctgagtaaa   2580

atggactttg atgatgaaag aacttggact gaccttgaag agaatttgtg taaccatgat   2640

gttgttcttg ggaatgaatc cacttatggg acgccgcaga catgctaccc taataatgaa   2700

ataggtatcc tggacaaaac aataaaaagg aagattgcac cagtcaagag gggagaagac   2760

ttgagcaagt ccaggaggag cagaagtcct cctacatcgg agctgatgat gaaattcttt   2820

ccttctttga aaccaaaacc aaagtcagat tcacacttgg gaaatgaact caagttaaac   2880

ataagtcaag accaaccacc tggtgacaat gctcgatccc aggttttgag agagaaaatt   2940

attgaattgg aaacagaaat agaaaagttt aaagctgaga acgcatcttt agctaaactt   3000

cgcattgaac gagaaagtgc cttggaaaaa ctcaggaaag aaattgcaga cttcgaacaa   3060

cagaaagcaa aagaattagc tcgaatagaa gagtttaaaa aggaggagat gaggaagcta   3120

caaaaggaac gtaaagtttt tgaaaagtat actacagctg caagaacttt tccagataaa   3180

aaggaacgtg aagaaataca gactttaaaa cagcaaatag cagatttacg ggaagatttg   3240

aaaagaaagg agaccaaatg gtcaagtaca cacagccgtc tcagaagcca gatacaaatg   3300

ttagtcagag agaacacaga cctccgggaa gaaataaaag tgatggaaag attccgactg   3360

gatgcctgga agagagcaga agccatagag agcagcctcg aggtggagaa gaaggacaag   3420

cttgcgaaca catctgttcg atttcaaaac agtcagattt cttcaggaac ccaggtagaa   3480

aaatacaaga aaaattatct tccaatgcaa ggcaatccac ctcgaagatc caagtctgca   3540

cctcctcgtg atttaggcaa tttggataag ggacaagctg cctctcccag ggagccactt   3600

gaaccactga acttcccaga tcctgaatat aaagaggagg aggaagacca agacatacag   3660

ggagaaatca gtcatcctga tggaaaggtg gaaaaggttt ataagaatgg gtgccgtgtt   3720

atactgtttc ccaatggaac tcgaaaggaa gtgagtgcag atgggaagac catcactgtc   3780

actttcttta atggtgacgt gaagcaggtc atgccagacc aaagagtgat ttactactat   3840

gcagctgccc agaccactca cacgacatac ccggagggac tggaagtttt acatttttca   3900

agtggacaaa tagaaaaaca ttacccagat ggaaggaaag aaatcacgtt tcctgaccag   3960

actgttaaaa acttatttcc tgatggacaa gaagaaagca ttttcccaga tggtacaatt   4020

gtcagagtac aacgtgatgg caacaaactc atagagttta ataatggcca aagagaacta   4080

catactgccc agttcaagag acgggaatac ccagatggca ctgttaaaac cgtatatgca   4140

aacggtcatc aagaaacgaa gtacagatcc ggtcggataa gagttaagga caaggagggt   4200

aatgtgtcaa tggacacgga gctgtgacga tcctcatgtg atcatgaagt aacagtaact   4260

gactttttat gttaaaaaat gtacatttac tgtggattct gtttaattta ttgtgtatgt   4320

gtggggaaaa gattggattt taaaataaaa gtttaccctg tggcattttc aaaaaaaaaa   4380

aaaaaaa                                                             4387


<210>  3088
<211>  1338
<212>  PRT
<213>  Homosapiens

<400>  3088

Met Phe Leu Met Pro Thr Ser Ser Glu Leu Asn Ser Gly Gln Asn Phe 
1               5                   10                  15      


Leu Thr Gln Trp Met Thr Asn Pro Ser Arg Ala Gly Val Ile Leu Asn 
            20                  25                  30          


Arg Gly Phe Pro Ile Leu Glu Ala Asp Lys Glu Lys Arg Ala Ala Val 
        35                  40                  45              


Asp Ile Ser Thr Ser Phe Pro Ile Lys Gly Thr His Phe Ser Asp Ser 
    50                  55                  60                  


Phe Ser Phe Ile Asn Glu Glu Asp Ser Leu Leu Glu Glu Gln Lys Leu 
65                  70                  75                  80  


Glu Ser Asn Asn Pro Tyr Lys Pro Gln Ser Asp Lys Ser Glu Thr His 
                85                  90                  95      


Thr Ala Phe Pro Cys Ile Lys Lys Gly Pro Gln Val Ala Ala Cys His 
            100                 105                 110         


Ser Ala Pro Gly His Gln Glu Glu Asn Lys Asn Asp Phe Ile Pro Asp 
        115                 120                 125             


Arg Ala Ser Glu Phe Lys Glu Gly Ala Tyr Lys Asp Pro Leu Phe Lys 
    130                 135                 140                 


Lys Leu Glu Gln Leu Lys Glu Val Gln Gln Lys Lys Gln Glu Gln Leu 
145                 150                 155                 160 


Lys Arg Gln Gln Leu Glu Gln Leu Gln Arg Leu Met Glu Glu Gln Glu 
                165                 170                 175     


Lys Leu Leu Thr Met Val Ser Gly Gln Cys Thr Leu Pro Gly Leu Ser 
            180                 185                 190         


Leu Leu Pro Asp Asp Gln Ser Gln Lys His Arg Ser Pro Gly Asn Thr 
        195                 200                 205             


Thr Thr Gly Glu Arg Ala Thr Cys Cys Phe Pro Ser Tyr Val Tyr Pro 
    210                 215                 220                 


Asp Pro Thr Gln Glu Glu Thr Tyr Pro Ser Asn Ile Leu Ser His Glu 
225                 230                 235                 240 


Gln Ser Asn Phe Cys Arg Thr Ala His Gly Asp Phe Val Leu Thr Ser 
                245                 250                 255     


Lys Arg Ala Ser Pro Asn Leu Phe Ser Glu Ala Gln Tyr Gln Glu Ala 
            260                 265                 270         


Pro Val Glu Lys Asn Asn Leu Lys Glu Glu Asn Arg Asn His Pro Thr 
        275                 280                 285             


Gly Glu Ser Ile Leu Cys Trp Glu Lys Val Thr Glu Gln Ile Gln Glu 
    290                 295                 300                 


Ala Asn Asp Lys Asn Leu Gln Lys His Asp Asp Ser Ser Glu Val Ala 
305                 310                 315                 320 


Asn Ile Glu Glu Arg Pro Ile Lys Ala Ala Ile Gly Glu Arg Lys Gln 
                325                 330                 335     


Thr Phe Glu Asp Tyr Leu Glu Glu Gln Ile Gln Leu Glu Glu Gln Glu 
            340                 345                 350         


Leu Lys Gln Lys Gln Leu Lys Glu Ala Glu Gly Pro Leu Pro Ile Lys 
        355                 360                 365             


Ala Lys Pro Lys Gln Pro Phe Leu Lys Arg Gly Glu Gly Leu Ala Arg 
    370                 375                 380                 


Phe Thr Asn Ala Lys Ser Lys Phe Gln Lys Gly Lys Glu Ser Lys Leu 
385                 390                 395                 400 


Val Thr Asn Gln Ser Thr Ser Glu Asp Gln Pro Leu Phe Lys Met Asp 
                405                 410                 415     


Arg Gln Gln Leu Gln Arg Lys Thr Ala Leu Lys Asn Lys Glu Leu Cys 
            420                 425                 430         


Ala Asp Asn Pro Ile Leu Lys Lys Asp Ser Lys Ala Arg Thr Lys Ser 
        435                 440                 445             


Gly Ser Val Thr Leu Ser Gln Lys Pro Lys Met Leu Lys Cys Ser Asn 
    450                 455                 460                 


Arg Lys Ser Leu Ser Pro Ser Gly Leu Lys Ile Gln Thr Gly Lys Lys 
465                 470                 475                 480 


Cys Asp Gly Gln Phe Arg Asp Gln Ile Lys Phe Glu Asn Lys Val Thr 
                485                 490                 495     


Ser Asn Asn Lys Glu Asn Val Thr Glu Cys Pro Lys Pro Cys Asp Thr 
            500                 505                 510         


Gly Cys Thr Gly Trp Asn Lys Thr Gln Gly Lys Asp Arg Leu Pro Leu 
        515                 520                 525             


Ser Thr Gly Pro Ala Ser Arg Leu Ala Ala Lys Ser Pro Ile Arg Glu 
    530                 535                 540                 


Thr Met Lys Glu Ser Glu Ser Ser Leu Asp Val Ser Leu Gln Lys Lys 
545                 550                 555                 560 


Leu Glu Thr Trp Glu Arg Glu Lys Glu Lys Glu Asn Leu Glu Leu Asp 
                565                 570                 575     


Glu Phe Leu Phe Leu Glu Gln Ala Ala Asp Glu Ile Ser Phe Ser Ser 
            580                 585                 590         


Asn Ser Ser Phe Val Leu Lys Ile Leu Glu Arg Asp Gln Gln Ile Cys 
        595                 600                 605             


Lys Gly His Arg Met Ser Ser Thr Pro Val Lys Ala Val Pro Gln Lys 
    610                 615                 620                 


Thr Asn Pro Ala Asp Pro Ile Ser His Cys Asn Arg Ser Glu Asp Leu 
625                 630                 635                 640 


Asp His Thr Ala Arg Glu Lys Glu Ser Glu Cys Glu Val Ala Pro Lys 
                645                 650                 655     


Gln Leu His Ser Leu Ser Ser Ala Asp Glu Leu Arg Glu Gln Pro Cys 
            660                 665                 670         


Lys Ile Arg Lys Ala Val Gln Lys Ser Thr Ser Glu Asn Gln Thr Glu 
        675                 680                 685             


Trp Asn Ala Arg Asp Asp Glu Gly Val Pro Asn Ser Asp Ser Ser Thr 
    690                 695                 700                 


Asp Ser Glu Glu Gln Leu Asp Val Thr Ile Lys Pro Ser Thr Glu Asp 
705                 710                 715                 720 


Arg Glu Arg Gly Ile Ser Ser Arg Glu Asp Ser Pro Gln Val Cys Asp 
                725                 730                 735     


Asp Lys Gly Pro Phe Lys Asp Thr Arg Thr Gln Glu Asp Lys Arg Arg 
            740                 745                 750         


Asp Val Asp Leu Asp Leu Ser Asp Lys Asp Tyr Ser Ser Asp Glu Ser 
        755                 760                 765             


Ile Met Glu Ser Ile Lys His Lys Val Ser Glu Pro Ser Arg Ser Ser 
    770                 775                 780                 


Ser Leu Ser Leu Ser Lys Met Asp Phe Asp Asp Glu Arg Thr Trp Thr 
785                 790                 795                 800 


Asp Leu Glu Glu Asn Leu Cys Asn His Asp Val Val Leu Gly Asn Glu 
                805                 810                 815     


Ser Thr Tyr Gly Thr Pro Gln Thr Cys Tyr Pro Asn Asn Glu Ile Gly 
            820                 825                 830         


Ile Leu Asp Lys Thr Ile Lys Arg Lys Ile Ala Pro Val Lys Arg Gly 
        835                 840                 845             


Glu Asp Leu Ser Lys Ser Arg Arg Ser Arg Ser Pro Pro Thr Ser Glu 
    850                 855                 860                 


Leu Met Met Lys Phe Phe Pro Ser Leu Lys Pro Lys Pro Lys Ser Asp 
865                 870                 875                 880 


Ser His Leu Gly Asn Glu Leu Lys Leu Asn Ile Ser Gln Asp Gln Pro 
                885                 890                 895     


Pro Gly Asp Asn Ala Arg Ser Gln Val Leu Arg Glu Lys Ile Ile Glu 
            900                 905                 910         


Leu Glu Thr Glu Ile Glu Lys Phe Lys Ala Glu Asn Ala Ser Leu Ala 
        915                 920                 925             


Lys Leu Arg Ile Glu Arg Glu Ser Ala Leu Glu Lys Leu Arg Lys Glu 
    930                 935                 940                 


Ile Ala Asp Phe Glu Gln Gln Lys Ala Lys Glu Leu Ala Arg Ile Glu 
945                 950                 955                 960 


Glu Phe Lys Lys Glu Glu Met Arg Lys Leu Gln Lys Glu Arg Lys Val 
                965                 970                 975     


Phe Glu Lys Tyr Thr Thr Ala Ala Arg Thr Phe Pro Asp Lys Lys Glu 
            980                 985                 990         


Arg Glu Glu Ile Gln Thr Leu Lys  Gln Gln Ile Ala Asp  Leu Arg Glu 
        995                 1000                 1005             


Asp Leu  Lys Arg Lys Glu Thr  Lys Trp Ser Ser Thr  His Ser Arg 
    1010                 1015                 1020             


Leu Arg  Ser Gln Ile Gln Met  Leu Val Arg Glu Asn  Thr Asp Leu 
    1025                 1030                 1035             


Arg Glu  Glu Ile Lys Val Met  Glu Arg Phe Arg Leu  Asp Ala Trp 
    1040                 1045                 1050             


Lys Arg  Ala Glu Ala Ile Glu  Ser Ser Leu Glu Val  Glu Lys Lys 
    1055                 1060                 1065             


Asp Lys  Leu Ala Asn Thr Ser  Val Arg Phe Gln Asn  Ser Gln Ile 
    1070                 1075                 1080             


Ser Ser  Gly Thr Gln Val Glu  Lys Tyr Lys Lys Asn  Tyr Leu Pro 
    1085                 1090                 1095             


Met Gln  Gly Asn Pro Pro Arg  Arg Ser Lys Ser Ala  Pro Pro Arg 
    1100                 1105                 1110             


Asp Leu  Gly Asn Leu Asp Lys  Gly Gln Ala Ala Ser  Pro Arg Glu 
    1115                 1120                 1125             


Pro Leu  Glu Pro Leu Asn Phe  Pro Asp Pro Glu Tyr  Lys Glu Glu 
    1130                 1135                 1140             


Glu Glu  Asp Gln Asp Ile Gln  Gly Glu Ile Ser His  Pro Asp Gly 
    1145                 1150                 1155             


Lys Val  Glu Lys Val Tyr Lys  Asn Gly Cys Arg Val  Ile Leu Phe 
    1160                 1165                 1170             


Pro Asn  Gly Thr Arg Lys Glu  Val Ser Ala Asp Gly  Lys Thr Ile 
    1175                 1180                 1185             


Thr Val  Thr Phe Phe Asn Gly  Asp Val Lys Gln Val  Met Pro Asp 
    1190                 1195                 1200             


Gln Arg  Val Ile Tyr Tyr Tyr  Ala Ala Ala Gln Thr  Thr His Thr 
    1205                 1210                 1215             


Thr Tyr  Pro Glu Gly Leu Glu  Val Leu His Phe Ser  Ser Gly Gln 
    1220                 1225                 1230             


Ile Glu  Lys His Tyr Pro Asp  Gly Arg Lys Glu Ile  Thr Phe Pro 
    1235                 1240                 1245             


Asp Gln  Thr Val Lys Asn Leu  Phe Pro Asp Gly Gln  Glu Glu Ser 
    1250                 1255                 1260             


Ile Phe  Pro Asp Gly Thr Ile  Val Arg Val Gln Arg  Asp Gly Asn 
    1265                 1270                 1275             


Lys Leu  Ile Glu Phe Asn Asn  Gly Gln Arg Glu Leu  His Thr Ala 
    1280                 1285                 1290             


Gln Phe  Lys Arg Arg Glu Tyr  Pro Asp Gly Thr Val  Lys Thr Val 
    1295                 1300                 1305             


Tyr Ala  Asn Gly His Gln Glu  Thr Lys Tyr Arg Ser  Gly Arg Ile 
    1310                 1315                 1320             


Arg Val  Lys Asp Lys Glu Gly  Asn Val Ser Met Asp  Thr Glu Leu 
    1325                 1330                 1335             


<210>  3089
<211>  894
<212>  DNA
<213>  Homosapiens

<400>  3089
atgtctggca agtcgcagag tggctgggtg tgtgggaacc atgcccgtga ccggtcctcg     60

gggatgctgc tgctgcagtc gctgagggtc ctagttgctg ggcgctacac ctgcacggct    120

gacccagggt ctccatggcc tgtcactgtg ccagctgccc gagagaggaa agcacgcttg    180

atcccgtcac gaacacattt agtacgcatg gaaccactac aggccctgcg gacatgtttc    240

tttgttttgg acaatctcct aagaacttta ggtcttacag cacgaacccc tcaaagtctg    300

cctgggcaca cgctacatgc agattttggt gctttcccaa ccttcttgaa gaaacactat    360

aatgatgtca aaaaatttag cacacggcgc gggcgcaggc gcggagaggc gcacaggaga    420

cctcaggccc aggctccact ccccagctgt gaaaggaccg ctggccggac ccccaagcta    480

gcccgccagg cctccataga gctgcccagc atggccgtgg ccagtaccaa gagtcggtgg    540

gagacgggtg aggtacaggc tcagtctgcg accaagactc cgtcctgcaa ggcccagatt    600

gccttcctac agggagaaag gaaggaccaa gaaaatttga agaaggatct tgtgaggaag    660

atcaaaatgt tggagtatgc tcttaaacag aaaagagcca aataccacaa gttgaaatat    720

gggagagaat tgaatcaggg agatatgaag cctccaagct atgactctga ttccacatta    780

acaaaacagc cagttaatgt gaaaacaagg tcgacaacta ctcagacaaa ggtagttcag    840

tttctccaga ttaccacaga agacagctct gtggatcctc ctcagatgag atga          894


<210>  3090
<211>  2430
<212>  DNA
<213>  Homosapiens

<400>  3090
gcgctctact cctgtaacgg aaaggtcgcg gcttgtgtgc ctgcgggcag ccgtgccgag     60

aatgaacccc agcaccccca gctacccaac ggcctcgctc tacgtggggg acctccaccc    120

cgacgtgact gaggcgatgc tctacgagaa gttcagcccg gcagggccca tcctctccat    180

ccggatctgc agggacttga tcaccagcgg ctcctccaac tacgcgtatg tgaacttcca    240

gcatacgaag gacgcggagc atgctctgga caccatgaat tttgatgtta taaagggcaa    300

gccagtacgc atcatgtggt ctcagcgtga tccatcactt cgaaaaagtg gagtgggcaa    360

catattcgtt aaaaatctgg ataagtccat taataataaa gcactgtatg atacagtttc    420

tgcttttggt aacatccttt cgtgtaacgt ggtttgtgat gaaaatggtt ccaagggtta    480

tggatttgta cactttgaga cacacgaagc agctgaaaga gctattaaaa aaatgaacgg    540

aatgctccta aatggtcgca aagtatttgt tggacaattt aagtctcgta aagaacgaga    600

agctgaactt ggagctaggg caaaagagtt ccccaatgtt tacatcaaga attttggaga    660

agacatggat gatgagcgcc ttaaggatct ctttggcaag ttcgggcccg ccttaagtgt    720

gaaagtaatg accgatgaaa gtggaaaatc caaaggattt ggatttgtaa gctttgaaag    780

gcatgaagat gcacagaaag ctgtagatga gatgaatgga aaggagctca atggaaaaca    840

aatttacgtt ggtcgagctc agaaaaaagt ggaacggcag acggaactta agcgcacatt    900

tgaacagatg aagcaagata ggatcaccag ataccaggtt gttaatcttt atgtgaaaaa    960

tcttgatgat ggtattgatg atgaacgtct ccggaaagcg ttttctccat ttggtacaat   1020

cactagtgca aaggttatga tggaaggtgg tcgcagcaaa gggtttggtt ttgtatgttt   1080

ctcctcccca gaagaagcca ctaaagcagt tacagaaatg aacggtagaa ttgtggccac   1140

aaagccattg tatgtagctt tagctcagcg caaagaagag cgccaggctt acctcactaa   1200

cgagtatatg cagagaatgg caagtgtacg agctgtgccc aaccagcgag cacctccttc   1260

aggttacttc atgacagctg tcccacagac tcagaaccat gctgcatact atcctcctag   1320

ccaaattgct cgactaagac caagtcctcg ctggactgct cagggtgcca gacctcatcc   1380

attccaaaat aagcccagtg ctatccgccc aggtgctcct agagtaccat ttagtactat   1440

gagaccagct tcttcacagg ttccacgagt catgtcaacg cagcgtgttg ctaacacatc   1500

aacacagaca gtgggtccac gtcctgcagc tgctgctgct gctgcagcta cccctgctgt   1560

gcgcacggtt ccacggtata aatatgctgc gggagttcgc aatcctcagc aacatcgtaa   1620

tgcacagcca caagttacaa tgcaacagct tgctgttcat gtacaaggtc aggaaacttt   1680

gactgcctcc aggttggcat ctgcccctcc tcaaaagcaa aagcaaatgt taggtgaacg   1740

gctctttcct cttattcaag ccatgcaccc tactcttgct gggaaaatca ctggcatgtt   1800

gttggagatt gataattcag aacttcttta tatgctcgag tctccagagt cactccgttc   1860

taaggttgat gaagctgtag ctgtactaca agcccaccaa gctaaagagg ctacccagaa   1920

agcagttaac agtgctaccg gtgttccaac tgtttaaaat tgatcagaga ccacgaaaag   1980

aaatttgtgc ttcaccgaag aaaaatatct aaacatcgag aaactatggg aaaaaaaatt   2040

gcaaaatcta aaataaaaaa tgcaaaatct aaaataaaaa atggaaagga aactttgaac   2100

cttatgtacc gagcaaatgc aaggtctagc aaatataatg ctagtcctag attacttatt   2160

gatttaaaaa caaaaaaaag attacttaat tttgatttaa aaacaaaaaa tcgtaaaata   2220

caaaaaccag ttaatgtttt gtagaccctg ggaaaagaat tttcagcaaa gtacaaaaat   2280

ttaaagcatt cctttaattt tttaattctt tactgtggaa tagctcaaaa tgtccattct   2340

gttttaagta acagaattga taactgagca aggaaacatg gtttggatta taaaattctt   2400

gctttaataa aaatttctta aacagtgaaa                                    2430


<210>  3091
<211>  631
<212>  PRT
<213>  Homosapiens

<400>  3091

Met Asn Pro Ser Thr Pro Ser Tyr Pro Thr Ala Ser Leu Tyr Val Gly 
1               5                   10                  15      


Asp Leu His Pro Asp Val Thr Glu Ala Met Leu Tyr Glu Lys Phe Ser 
            20                  25                  30          


Pro Ala Gly Pro Ile Leu Ser Ile Arg Ile Cys Arg Asp Leu Ile Thr 
        35                  40                  45              


Ser Gly Ser Ser Asn Tyr Ala Tyr Val Asn Phe Gln His Thr Lys Asp 
    50                  55                  60                  


Ala Glu His Ala Leu Asp Thr Met Asn Phe Asp Val Ile Lys Gly Lys 
65                  70                  75                  80  


Pro Val Arg Ile Met Trp Ser Gln Arg Asp Pro Ser Leu Arg Lys Ser 
                85                  90                  95      


Gly Val Gly Asn Ile Phe Val Lys Asn Leu Asp Lys Ser Ile Asn Asn 
            100                 105                 110         


Lys Ala Leu Tyr Asp Thr Val Ser Ala Phe Gly Asn Ile Leu Ser Cys 
        115                 120                 125             


Asn Val Val Cys Asp Glu Asn Gly Ser Lys Gly Tyr Gly Phe Val His 
    130                 135                 140                 


Phe Glu Thr His Glu Ala Ala Glu Arg Ala Ile Lys Lys Met Asn Gly 
145                 150                 155                 160 


Met Leu Leu Asn Gly Arg Lys Val Phe Val Gly Gln Phe Lys Ser Arg 
                165                 170                 175     


Lys Glu Arg Glu Ala Glu Leu Gly Ala Arg Ala Lys Glu Phe Pro Asn 
            180                 185                 190         


Val Tyr Ile Lys Asn Phe Gly Glu Asp Met Asp Asp Glu Arg Leu Lys 
        195                 200                 205             


Asp Leu Phe Gly Lys Phe Gly Pro Ala Leu Ser Val Lys Val Met Thr 
    210                 215                 220                 


Asp Glu Ser Gly Lys Ser Lys Gly Phe Gly Phe Val Ser Phe Glu Arg 
225                 230                 235                 240 


His Glu Asp Ala Gln Lys Ala Val Asp Glu Met Asn Gly Lys Glu Leu 
                245                 250                 255     


Asn Gly Lys Gln Ile Tyr Val Gly Arg Ala Gln Lys Lys Val Glu Arg 
            260                 265                 270         


Gln Thr Glu Leu Lys Arg Thr Phe Glu Gln Met Lys Gln Asp Arg Ile 
        275                 280                 285             


Thr Arg Tyr Gln Val Val Asn Leu Tyr Val Lys Asn Leu Asp Asp Gly 
    290                 295                 300                 


Ile Asp Asp Glu Arg Leu Arg Lys Ala Phe Ser Pro Phe Gly Thr Ile 
305                 310                 315                 320 


Thr Ser Ala Lys Val Met Met Glu Gly Gly Arg Ser Lys Gly Phe Gly 
                325                 330                 335     


Phe Val Cys Phe Ser Ser Pro Glu Glu Ala Thr Lys Ala Val Thr Glu 
            340                 345                 350         


Met Asn Gly Arg Ile Val Ala Thr Lys Pro Leu Tyr Val Ala Leu Ala 
        355                 360                 365             


Gln Arg Lys Glu Glu Arg Gln Ala Tyr Leu Thr Asn Glu Tyr Met Gln 
    370                 375                 380                 


Arg Met Ala Ser Val Arg Ala Val Pro Asn Gln Arg Ala Pro Pro Ser 
385                 390                 395                 400 


Gly Tyr Phe Met Thr Ala Val Pro Gln Thr Gln Asn His Ala Ala Tyr 
                405                 410                 415     


Tyr Pro Pro Ser Gln Ile Ala Arg Leu Arg Pro Ser Pro Arg Trp Thr 
            420                 425                 430         


Ala Gln Gly Ala Arg Pro His Pro Phe Gln Asn Lys Pro Ser Ala Ile 
        435                 440                 445             


Arg Pro Gly Ala Pro Arg Val Pro Phe Ser Thr Met Arg Pro Ala Ser 
    450                 455                 460                 


Ser Gln Val Pro Arg Val Met Ser Thr Gln Arg Val Ala Asn Thr Ser 
465                 470                 475                 480 


Thr Gln Thr Val Gly Pro Arg Pro Ala Ala Ala Ala Ala Ala Ala Ala 
                485                 490                 495     


Thr Pro Ala Val Arg Thr Val Pro Arg Tyr Lys Tyr Ala Ala Gly Val 
            500                 505                 510         


Arg Asn Pro Gln Gln His Arg Asn Ala Gln Pro Gln Val Thr Met Gln 
        515                 520                 525             


Gln Leu Ala Val His Val Gln Gly Gln Glu Thr Leu Thr Ala Ser Arg 
    530                 535                 540                 


Leu Ala Ser Ala Pro Pro Gln Lys Gln Lys Gln Met Leu Gly Glu Arg 
545                 550                 555                 560 


Leu Phe Pro Leu Ile Gln Ala Met His Pro Thr Leu Ala Gly Lys Ile 
                565                 570                 575     


Thr Gly Met Leu Leu Glu Ile Asp Asn Ser Glu Leu Leu Tyr Met Leu 
            580                 585                 590         


Glu Ser Pro Glu Ser Leu Arg Ser Lys Val Asp Glu Ala Val Ala Val 
        595                 600                 605             


Leu Gln Ala His Gln Ala Lys Glu Ala Thr Gln Lys Ala Val Asn Ser 
    610                 615                 620                 


Ala Thr Gly Val Pro Thr Val 
625                 630     


<210>  3092
<211>  4877
<212>  DNA
<213>  Homosapiens

<400>  3092
atggatggag gtgctttaac tgatacaagt ctcacagatt cctattttag caccagcttt     60

attggagtca atggatttgg aagccctgta gaaacaaaat atcccctgat gcagagaatg    120

actaatagta gcagctcccc aagccttcta aatgacagtg ccaagccata ttcagcccat    180

gatcctctaa catcacctgc ttcatccttg tttaatgact ttggtgccct caacatctct    240

cagagacgaa agacaccaaa tcctactgca agcgagttta ttcctaaagg aggatcaacc    300

tccaggctga gtaacgtgtc ccagtcaaat atgtctgcct tctctcaagt tttctctcac    360

ccatccatgg gaagccctgc tactgctgga ttagcgccag gaatgtcgtt gtctgctggg    420

tcttcccctc ttcattcccc caagattact ccacatactt ctcctgctcc cagaagaaga    480

agtcacactc caaatccagc aagttacatg gtgccttcta gtgcctctac atctgttaat    540

aatcctgttt ctcagactcc gtcttctggt caggtgatcc aaaaggaaac tgttggtggg    600

acgacttact tctatacaga cacaactcca gcacctttga ctggaatggt gtttccaaac    660

tatcatattt atcctccaac tgcacctcac gttgcttata tgcaaccgaa agcaaacgca    720

ccttccttct tcatggctga tgaactccga caggagctga tcaacagaca tttaataaca    780

atggctcaaa ttgatcaagc agatatgcca gcagttccta cagaggttga cagctaccat    840

agcctattcc ctctagaacc actgccacct cccaaccgga tacagaaatc aagtaatttt    900

ggatatatta catcttgcta caaagctgta aacagcaaag atgatctgcc atattgcctt    960

cggaggatac atggttttcg tcttgttaac acaaagtgca tggtgttggt cgacatgtgg   1020

aagaaaattc aacactcaaa tatcgtaact ttgcgtgaag tatttaccac taaagcattt   1080

gctgagccct ctcttgtgtt tgcatatgat ttccatgctg gaggagaaac tatgatgagc   1140

agacacttta atgaccctaa tgctgatgcc tacttcacca agagaaagtg gggtcagcac   1200

gagggaccat tgcccaggca gcatgctgga ttattgccag aatctcttat ttgggcatat   1260

attgtccaac taagttctgc attgcgtacc attcatacag caggtttggc atgtcgagtt   1320

atggatccaa caaagattct gataactggc aaaacaaggt tgcgagtaaa ttgtgttgga   1380

gtttttgatg ttttaacatt tgataacagt caaaataata atccattggc attaatggcc   1440

cagtaccagc aagcagatct gatatcatta ggaaaagttg tgttggcttt ggcttgcaac   1500

tctttggcag gaattcagcg agagaattta cagaaagcca tggaactggt gacaatcaac   1560

tattcctctg acctgaagaa tctgattttg tatttgttga ctgaccaaaa caggatgcga   1620

agtgtaaatg acatcatgcc catgattggt gctcgatttt atactcaatt ggatgctgct   1680

caaatgagaa atgatgtcat agaggaagac cttgcaaagg aggttcaaaa tggaagactg   1740

tttaggctcc tagcaaaatt gggaacaatc aatgagaggc cggagtttca gaaggatccc   1800

acttggtcag agactggaga ccgttatctg ttgaaactct ttagggatca tctttttcat   1860

caggtgacag aagcaggtgc tccctggatt gacctcagtc atataatttc ttgtcttaac   1920

aagctagatg ctggtgtgcc agaaaaaata agcctgattt ccagagatga gaagagtgta   1980

cttgtggtga cctacagtga cttaaagcgc tgctttgaaa atacttttca agaactgatt   2040

gcagctgcaa atggtcagtt gtagtatttg ctaaaaaagc acgcaggaca tggctaaaga   2100

ccttaaccaa tagcaaattg cactacagct gaacttttca tcatctcatt cacatttggg   2160

aaacgaacag gagatgagca aagctgcttg cacttcagtc aggtacactg ttacttgaaa   2220

ggaagaatgt ttcacttacc caagagctat ggctgccatt ggaggctgtt atctgtgaag   2280

aatttatttt agatttagga gcaccatcag gtgaatgatg ttcctgcttt tgttttttcc   2340

acttgtatat gcactaattt taatttttta aagacttttt ctgatctttg aacttttgcc   2400

acattgtata cttataatgg gaaactttgc aaggacattt ttgggaagca atgctgggca   2460

gcgtttttgc cattgagggt tgcagaattt gctctttttg ggatgggttg ccctgaataa   2520

cattacggac caggtaaata atttcataga agttcagtat agtacgtaat tcttgtaaga   2580

gtatcgtatg caagctctct gtatgccacc cactgttagt tcaaattgag atttttgttt   2640

tgttttgttc ttaagaacat accaagaaaa taccagtgaa ttgttggata tgaattccct   2700

gttagttgat ttaaatcctt tctgaataaa gatcagataa acagtaactg aaggagcatg   2760

tatagctctt tccttcaaat tcaactagag cctttttaaa aagacatttg cctgctagtc   2820

agatacattt acatttatgc aaatttttta aataggagaa aattaagaaa ttgtgttaaa   2880

ggcctaaagt tcaggagtgt attactttag gttctttcca gtttgctggt tttttttttt   2940

tttttttttt ttttttttgg gcggggggga ggtttatgaa gttttgctct ttgaaccaca   3000

gctttattat ggtcctttac actggagaca gacacagaga cactgttcag aagatgaact   3060

aaactcagca gtggtctggt atcaagagct ttctgatgtt ttacagcctg aatttggagg   3120

gataacgatc tgctgtgcct ttgcagtcac tgcttagccc aaagtaatag tacttttgat   3180

aataactcac tctgtgcgat attcctgaat aagtccatct caaaagtttg ggattttcct   3240

cctcttaact ttcttaatat ttggacatgc agttgtcgcc aaacttgggt attcatggaa   3300

tttctagtaa atgaaatacc tatactttga tactgaagac tgccaaatac ataggaattt   3360

tctttcttaa aaaacagtaa tgaagactat atctcctttc ccagcactga atgttttact   3420

agcactgggt gctcaccatg caactgaaga aaatgtggaa actcaaaagg tcaggacaga   3480

cttccaagca cttgcaactg atgttactgt cttcaatttt aataattaca catatttgta   3540

tatttcagag aagtttttaa tatttctctg tccacttttt ataagcttta aaatgatttt   3600

ctctgccttg agatttgcat caagaaaaag cacctctctt cacctgaaag ctttgaagac   3660

tagagacacg ctttacacgt tttaacaagt atattgagtc cacgtttggt agcatcagtt   3720

gttgagttaa aaagaaaatt attgcatttg atctggatgg attttaaaag aatataatgt   3780

tcaatattaa aaggataatt cacatttgcc accataatgt tcttttttat gtaaaaagaa   3840

gaacttggag acattaacat gaaaaagtct tttatcatta gctcatgtat ttgaggaaga   3900

gcagctgtct ttttatatgt tttttgacaa atcatattgt attcttttgt acaaaaaaga   3960

actacttgta ttctagaaga aatatgaaat gcttaattta taagcgggct ggagattttt   4020

tccaatattg ttttctttga aaatgaaagg ggatcatcta ttttagtttt ggggtctggg   4080

aactttttga aaatttaatt tgtggaccaa tgttttgtga aagctaaaga gggcaggggt   4140

taaaataggg cttgaatttc tcattctgta tagaccagca aacttccctg tgcaaggcaa   4200

gtttacatca caaatccaag aatgtttgca tcctaaatgc tagtttgctt cagcccctag   4260

ttaacctcag gacttggttt gcatataaaa ggtagacagc tgatatgttt tcatgaataa   4320

atattgtcag ccagaaaagg ttggtgtcag gtaatgcata tttttttaag ctttgtttta   4380

tatttatttt tcatttagtt tttattggga atggttttca aagaactctc agttctgcct   4440

aggtgttttt gggggagccc tgttttccat agtgtaattc catttaagag gttgtctaaa   4500

agtcttttta attaatagaa agattttaat atccaagagt agtcaaatta aggatataaa   4560

ctttccacac cttcctgtcg tgacagataa aagcacagaa aggacaaccc ttgaaatcat   4620

gtaacgttgg tcatttcaat attttgtacc tgttttaaat tctgttagtg tatttacttc   4680

attgtaaata tttttgaggg tacctttgta ttttgctttt gaccttggtt ctgtgatttg   4740

gatgtcaaca acttccctaa aaagcaccag tgtgttaggt tctaatgtca tgacccaatt   4800

tgtgttattc atctttaatc ctgttttcag tctctatgtg tacagcagta tttttaataa   4860

agaattacag agataaa                                                  4877


<210>  3093
<211>  687
<212>  PRT
<213>  Homosapiens

<400>  3093

Met Asp Gly Gly Ala Leu Thr Asp Thr Ser Leu Thr Asp Ser Tyr Phe 
1               5                   10                  15      


Ser Thr Ser Phe Ile Gly Val Asn Gly Phe Gly Ser Pro Val Glu Thr 
            20                  25                  30          


Lys Tyr Pro Leu Met Gln Arg Met Thr Asn Ser Ser Ser Ser Pro Ser 
        35                  40                  45              


Leu Leu Asn Asp Ser Ala Lys Pro Tyr Ser Ala His Asp Pro Leu Thr 
    50                  55                  60                  


Ser Pro Ala Ser Ser Leu Phe Asn Asp Phe Gly Ala Leu Asn Ile Ser 
65                  70                  75                  80  


Gln Arg Arg Lys Thr Pro Asn Pro Thr Ala Ser Glu Phe Ile Pro Lys 
                85                  90                  95      


Gly Gly Ser Thr Ser Arg Leu Ser Asn Val Ser Gln Ser Asn Met Ser 
            100                 105                 110         


Ala Phe Ser Gln Val Phe Ser His Pro Ser Met Gly Ser Pro Ala Thr 
        115                 120                 125             


Ala Gly Leu Ala Pro Gly Met Ser Leu Ser Ala Gly Ser Ser Pro Leu 
    130                 135                 140                 


His Ser Pro Lys Ile Thr Pro His Thr Ser Pro Ala Pro Arg Arg Arg 
145                 150                 155                 160 


Ser His Thr Pro Asn Pro Ala Ser Tyr Met Val Pro Ser Ser Ala Ser 
                165                 170                 175     


Thr Ser Val Asn Asn Pro Val Ser Gln Thr Pro Ser Ser Gly Gln Val 
            180                 185                 190         


Ile Gln Lys Glu Thr Val Gly Gly Thr Thr Tyr Phe Tyr Thr Asp Thr 
        195                 200                 205             


Thr Pro Ala Pro Leu Thr Gly Met Val Phe Pro Asn Tyr His Ile Tyr 
    210                 215                 220                 


Pro Pro Thr Ala Pro His Val Ala Tyr Met Gln Pro Lys Ala Asn Ala 
225                 230                 235                 240 


Pro Ser Phe Phe Met Ala Asp Glu Leu Arg Gln Glu Leu Ile Asn Arg 
                245                 250                 255     


His Leu Ile Thr Met Ala Gln Ile Asp Gln Ala Asp Met Pro Ala Val 
            260                 265                 270         


Pro Thr Glu Val Asp Ser Tyr His Ser Leu Phe Pro Leu Glu Pro Leu 
        275                 280                 285             


Pro Pro Pro Asn Arg Ile Gln Lys Ser Ser Asn Phe Gly Tyr Ile Thr 
    290                 295                 300                 


Ser Cys Tyr Lys Ala Val Asn Ser Lys Asp Asp Leu Pro Tyr Cys Leu 
305                 310                 315                 320 


Arg Arg Ile His Gly Phe Arg Leu Val Asn Thr Lys Cys Met Val Leu 
                325                 330                 335     


Val Asp Met Trp Lys Lys Ile Gln His Ser Asn Ile Val Thr Leu Arg 
            340                 345                 350         


Glu Val Phe Thr Thr Lys Ala Phe Ala Glu Pro Ser Leu Val Phe Ala 
        355                 360                 365             


Tyr Asp Phe His Ala Gly Gly Glu Thr Met Met Ser Arg His Phe Asn 
    370                 375                 380                 


Asp Pro Asn Ala Asp Ala Tyr Phe Thr Lys Arg Lys Trp Gly Gln His 
385                 390                 395                 400 


Glu Gly Pro Leu Pro Arg Gln His Ala Gly Leu Leu Pro Glu Ser Leu 
                405                 410                 415     


Ile Trp Ala Tyr Ile Val Gln Leu Ser Ser Ala Leu Arg Thr Ile His 
            420                 425                 430         


Thr Ala Gly Leu Ala Cys Arg Val Met Asp Pro Thr Lys Ile Leu Ile 
        435                 440                 445             


Thr Gly Lys Thr Arg Leu Arg Val Asn Cys Val Gly Val Phe Asp Val 
    450                 455                 460                 


Leu Thr Phe Asp Asn Ser Gln Asn Asn Asn Pro Leu Ala Leu Met Ala 
465                 470                 475                 480 


Gln Tyr Gln Gln Ala Asp Leu Ile Ser Leu Gly Lys Val Val Leu Ala 
                485                 490                 495     


Leu Ala Cys Asn Ser Leu Ala Gly Ile Gln Arg Glu Asn Leu Gln Lys 
            500                 505                 510         


Ala Met Glu Leu Val Thr Ile Asn Tyr Ser Ser Asp Leu Lys Asn Leu 
        515                 520                 525             


Ile Leu Tyr Leu Leu Thr Asp Gln Asn Arg Met Arg Ser Val Asn Asp 
    530                 535                 540                 


Ile Met Pro Met Ile Gly Ala Arg Phe Tyr Thr Gln Leu Asp Ala Ala 
545                 550                 555                 560 


Gln Met Arg Asn Asp Val Ile Glu Glu Asp Leu Ala Lys Glu Val Gln 
                565                 570                 575     


Asn Gly Arg Leu Phe Arg Leu Leu Ala Lys Leu Gly Thr Ile Asn Glu 
            580                 585                 590         


Arg Pro Glu Phe Gln Lys Asp Pro Thr Trp Ser Glu Thr Gly Asp Arg 
        595                 600                 605             


Tyr Leu Leu Lys Leu Phe Arg Asp His Leu Phe His Gln Val Thr Glu 
    610                 615                 620                 


Ala Gly Ala Pro Trp Ile Asp Leu Ser His Ile Ile Ser Cys Leu Asn 
625                 630                 635                 640 


Lys Leu Asp Ala Gly Val Pro Glu Lys Ile Ser Leu Ile Ser Arg Asp 
                645                 650                 655     


Glu Lys Ser Val Leu Val Val Thr Tyr Ser Asp Leu Lys Arg Cys Phe 
            660                 665                 670         


Glu Asn Thr Phe Gln Glu Leu Ile Ala Ala Ala Asn Gly Gln Leu 
        675                 680                 685         


<210>  3094
<211>  5777
<212>  DNA
<213>  Homosapiens

<400>  3094
gcggacactc ctctcggctc ctccccggca gcggcggcgg ctcggagcgg gctccggggc     60

tcgggtgcag cggccagcgg gcctggcggc gaggattacc cggggaagtg gttgtctcct    120

ggctggagcc gcgagacggg cgctcagggc gcggggccgg cggcggcgaa cgagaggacg    180

gactctggcg gccgggtcgt tggccggggg agcgcgggca ccgggcgagc aggccgcgtc    240

gcgctcacca tggtcagcta ctgggacacc ggggtcctgc tgtgcgcgct gctcagctgt    300

ctgcttctca caggatctag ttcaggttca aaattaaaag atcctgaact gagtttaaaa    360

ggcacccagc acatcatgca agcaggccag acactgcatc tccaatgcag gggggaagca    420

gcccataaat ggtctttgcc tgaaatggtg agtaaggaaa gcgaaaggct gagcataact    480

aaatctgcct gtggaagaaa tggcaaacaa ttctgcagta ctttaacctt gaacacagct    540

caagcaaacc acactggctt ctacagctgc aaatatctag ctgtacctac ttcaaagaag    600

aaggaaacag aatctgcaat ctatatattt attagtgata caggtagacc tttcgtagag    660

atgtacagtg aaatccccga aattatacac atgactgaag gaagggagct cgtcattccc    720

tgccgggtta cgtcacctaa catcactgtt actttaaaaa agtttccact tgacactttg    780

atccctgatg gaaaacgcat aatctgggac agtagaaagg gcttcatcat atcaaatgca    840

acgtacaaag aaatagggct tctgacctgt gaagcaacag tcaatgggca tttgtataag    900

acaaactatc tcacacatcg acaaaccaat acaatcatag atgtccaaat aagcacacca    960

cgcccagtca aattacttag aggccatact cttgtcctca attgtactgc taccactccc   1020

ttgaacacga gagttcaaat gacctggagt taccctgatg aaaaaaataa gagagcttcc   1080

gtaaggcgac gaattgacca aagcaattcc catgccaaca tattctacag tgttcttact   1140

attgacaaaa tgcagaacaa agacaaagga ctttatactt gtcgtgtaag gagtggacca   1200

tcattcaaat ctgttaacac ctcagtgcat atatatgata aagcattcat cactgtgaaa   1260

catcgaaaac agcaggtgct tgaaaccgta gctggcaagc ggtcttaccg gctctctatg   1320

aaagtgaagg catttccctc gccggaagtt gtatggttaa aagatgggtt acctgcgact   1380

gagaaatctg ctcgctattt gactcgtggc tactcgttaa ttatcaagga cgtaactgaa   1440

gaggatgcag ggaattatac aatcttgctg agcataaaac agtcaaatgt gtttaaaaac   1500

ctcactgcca ctctaattgt caatgtgaaa ccccagattt acgaaaaggc cgtgtcatcg   1560

tttccagacc cggctctcta cccactgggc agcagacaaa tcctgacttg taccgcatat   1620

ggtatccctc aacctacaat caagtggttc tggcacccct gtaaccataa tcattccgaa   1680

gcaaggtgtg acttttgttc caataatgaa gagtccttta tcctggatgc tgacagcaac   1740

atgggaaaca gaattgagag catcactcag cgcatggcaa taatagaagg aaagaataag   1800

atggctagca ccttggttgt ggctgactct agaatttctg gaatctacat ttgcatagct   1860

tccaataaag ttgggactgt gggaagaaac ataagctttt atatcacaga tgtgccaaat   1920

gggtttcatg ttaacttgga aaaaatgccg acggaaggag aggacctgaa actgtcttgc   1980

acagttaaca agttcttata cagagacgtt acttggattt tactgcggac agttaataac   2040

agaacaatgc actacagtat tagcaagcaa aaaatggcca tcactaagga gcactccatc   2100

actcttaatc ttaccatcat gaatgtttcc ctgcaagatt caggcaccta tgcctgcaga   2160

gccaggaatg tatacacagg ggaagaaatc ctccagaaga aagaaattac aatcagagat   2220

caggaagcac catacctcct gcgaaacctc agtgatcaca cagtggccat cagcagttcc   2280

accactttag actgtcatgc taatggtgtc cccgagcctc agatcacttg gtttaaaaac   2340

aaccacaaaa tacaacaaga gcctggaatt attttaggac caggaagcag cacgctgttt   2400

attgaaagag tcacagaaga ggatgaaggt gtctatcact gcaaagccac caaccagaag   2460

ggctctgtgg aaagttcagc atacctcact gttcaaggaa cctcggacaa gtctaatctg   2520

gagctgatca ctctaacatg cacctgtgtg gctgcgactc tcttctggct cctattaacc   2580

ctccttatcc gaaaaatgaa aaggtcttct tctgaaataa agactgacta cctatcaatt   2640

ataatggacc cagatgaagt tcctttggat gagcagtgtg agcggctccc ttatgatgcc   2700

agcaagtggg agtttgcccg ggagagactt aaactgggca aatcacttgg aagaggggct   2760

tttggaaaag tggttcaagc atcagcattt ggcattaaga aatcacctac gtgccggact   2820

gtggctgtga aaatgctgaa agagggggcc acggccagcg agtacaaagc tctgatgact   2880

gagctaaaaa tcttgaccca cattggccac catctgaacg tggttaacct gctgggagcc   2940

tgcaccaagc aaggagggcc tctgatggtg attgttgaat actgcaaata tggaaatctc   3000

tccaactacc tcaagagcaa acgtgactta ttttttctca acaaggatgc agcactacac   3060

atggagccta agaaagaaaa aatggagcca ggcctggaac aaggcaagaa accaagacta   3120

gatagcgtca ccagcagcga aagctttgcg agctccggct ttcaggaaga taaaagtctg   3180

agtgatgttg aggaagagga ggattctgac ggtttctaca aggagcccat cactatggaa   3240

gatctgattt cttacagttt tcaagtggcc agaggcatgg agttcctgtc ttccagaaag   3300

tgcattcatc gggacctggc agcgagaaac attcttttat ctgagaacaa cgtggtgaag   3360

atttgtgatt ttggccttgc ccgggatatt tataagaacc ccgattatgt gagaaaagga   3420

gatactcgac ttcctctgaa atggatggct cccgaatcta tctttgacaa aatctacagc   3480

accaagagcg acgtgtggtc ttacggagta ttgctgtggg aaatcttctc cttaggtggg   3540

tctccatacc caggagtaca aatggatgag gacttttgca gtcgcctgag ggaaggcatg   3600

aggatgagag ctcctgagta ctctactcct gaaatctatc agatcatgct ggactgctgg   3660

cacagagacc caaaagaaag gccaagattt gcagaacttg tggaaaaact aggtgatttg   3720

cttcaagcaa atgtacaaca ggatggtaaa gactacatcc caatcaatgc catactgaca   3780

ggaaatagtg ggtttacata ctcaactcct gccttctctg aggacttctt caaggaaagt   3840

atttcagctc cgaagtttaa ttcaggaagc tctgatgatg tcagatatgt aaatgctttc   3900

aagttcatga gcctggaaag aatcaaaacc tttgaagaac ttttaccgaa tgccacctcc   3960

atgtttgatg actaccaggg cgacagcagc actctgttgg cctctcccat gctgaagcgc   4020

ttcacctgga ctgacagcaa acccaaggcc tcgctcaaga ttgacttgag agtaaccagt   4080

aaaagtaagg agtcggggct gtctgatgtc agcaggccca gtttctgcca ttccagctgt   4140

gggcacgtca gcgaaggcaa gcgcaggttc acctacgacc acgctgagct ggaaaggaaa   4200

atcgcgtgct gctccccgcc cccagactac aactcggtgg tcctgtactc caccccaccc   4260

atctagagtt tgacacgaag ccttatttct agaagcacat gtgtatttat acccccagga   4320

aactagcttt tgccagtatt atgcatatat aagtttacac ctttatcttt ccatgggagc   4380

cagctgcttt ttgtgatttt tttaatagtg cttttttttt ttgactaaca agaatgtaac   4440

tccagataga gaaatagtga caagtgaaga acactactgc taaatcctca tgttactcag   4500

tgttagagaa atccttccta aacccaatga cttccctgct ccaacccccg ccacctcagg   4560

gcacgcagga ccagtttgat tgaggagctg cactgatcac ccaatgcatc acgtacccca   4620

ctgggccagc cctgcagccc aaaacccagg gcaacaagcc cgttagcccc aggggatcac   4680

tggctggcct gagcaacatc tcgggagtcc tctagcaggc ctaagacatg tgaggaggaa   4740

aaggaaaaaa agcaaaaagc aagggagaaa agagaaaccg ggagaaggca tgagaaagaa   4800

tttgagacgc accatgtggg cacggagggg gacggggctc agcaatgcca tttcagtggc   4860

ttcccagctc tgacccttct acatttgagg gcccagccag gagcagatgg acagcgatga   4920

ggggacattt tctggattct gggaggcaag aaaaggacaa atatcttttt tggaactaaa   4980

gcaaatttta gacctttacc tatggaagtg gttctatgtc cattctcatt cgtggcatgt   5040

tttgatttgt agcactgagg gtggcactca actctgagcc catacttttg gctcctctag   5100

taagatgcac tgaaaactta gccagagtta ggttgtctcc aggccatgat ggccttacac   5160

tgaaaatgtc acattctatt ttgggtatta atatatagtc cagacactta actcaatttc   5220

ttggtattat tctgttttgc acagttagtt gtgaaagaaa gctgagaaga atgaaaatgc   5280

agtcctgagg agagttttct ccatatcaaa acgagggctg atggaggaaa aaggtcaata   5340

aggtcaaggg aagaccccgt ctctatacca accaaaccaa ttcaccaaca cagttgggac   5400

ccaaaacaca ggaagtcagt cacgtttcct tttcatttaa tggggattcc actatctcac   5460

actaatctga aaggatgtgg aagagcatta gctggcgcat attaagcact ttaagctcct   5520

tgagtaaaaa ggtggtatgt aatttatgca aggtatttct ccagttggga ctcaggatat   5580

tagttaatga gccatcacta gaagaaaagc ccattttcaa ctgctttgaa acttgcctgg   5640

ggtctgagca tgatgggaat agggagacag ggtaggaaag ggcgcctact cttcagggtc   5700

taaagatcaa gtgggccttg gatcgctaag ctggctctgt ttgatgctat ttatgcaagt   5760

tagggtctat gtattta                                                  5777


<210>  3095
<211>  1338
<212>  PRT
<213>  Homosapiens

<400>  3095

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg 
705                 710                 715                 720 


Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln 
                725                 730                 735     


Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser 
            740                 745                 750         


Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val Ala 
        755                 760                 765             


Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Leu Ile Arg Lys Met Lys 
    770                 775                 780                 


Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr Leu Ser Ile Ile Met Asp 
785                 790                 795                 800 


Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr Asp 
                805                 810                 815     


Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys Ser 
            820                 825                 830         


Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe Gly 
        835                 840                 845             


Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu Lys 
    850                 855                 860                 


Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu Lys 
865                 870                 875                 880 


Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly 
                885                 890                 895     


Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr Cys 
            900                 905                 910         


Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu Phe 
        915                 920                 925             


Phe Leu Asn Lys Asp Ala Ala Leu His Met Glu Pro Lys Lys Glu Lys 
    930                 935                 940                 


Met Glu Pro Gly Leu Glu Gln Gly Lys Lys Pro Arg Leu Asp Ser Val 
945                 950                 955                 960 


Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly Phe Gln Glu Asp Lys Ser 
                965                 970                 975     


Leu Ser Asp Val Glu Glu Glu Glu Asp Ser Asp Gly Phe Tyr Lys Glu 
            980                 985                 990         


Pro Ile Thr Met Glu Asp Leu Ile  Ser Tyr Ser Phe Gln  Val Ala Arg 
        995                 1000                 1005             


Gly Met  Glu Phe Leu Ser Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1010                 1015                 1020             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Asn Asn Val  Val Lys Ile 
    1025                 1030                 1035             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asn  Pro Asp Tyr 
    1040                 1045                 1050             


Val Arg  Lys Gly Asp Thr Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1055                 1060                 1065             


Glu Ser  Ile Phe Asp Lys Ile  Tyr Ser Thr Lys Ser  Asp Val Trp 
    1070                 1075                 1080             


Ser Tyr  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Gly Ser 
    1085                 1090                 1095             


Pro Tyr  Pro Gly Val Gln Met  Asp Glu Asp Phe Cys  Ser Arg Leu 
    1100                 1105                 1110             


Arg Glu  Gly Met Arg Met Arg  Ala Pro Glu Tyr Ser  Thr Pro Glu 
    1115                 1120                 1125             


Ile Tyr  Gln Ile Met Leu Asp  Cys Trp His Arg Asp  Pro Lys Glu 
    1130                 1135                 1140             


Arg Pro  Arg Phe Ala Glu Leu  Val Glu Lys Leu Gly  Asp Leu Leu 
    1145                 1150                 1155             


Gln Ala  Asn Val Gln Gln Asp  Gly Lys Asp Tyr Ile  Pro Ile Asn 
    1160                 1165                 1170             


Ala Ile  Leu Thr Gly Asn Ser  Gly Phe Thr Tyr Ser  Thr Pro Ala 
    1175                 1180                 1185             


Phe Ser  Glu Asp Phe Phe Lys  Glu Ser Ile Ser Ala  Pro Lys Phe 
    1190                 1195                 1200             


Asn Ser  Gly Ser Ser Asp Asp  Val Arg Tyr Val Asn  Ala Phe Lys 
    1205                 1210                 1215             


Phe Met  Ser Leu Glu Arg Ile  Lys Thr Phe Glu Glu  Leu Leu Pro 
    1220                 1225                 1230             


Asn Ala  Thr Ser Met Phe Asp  Asp Tyr Gln Gly Asp  Ser Ser Thr 
    1235                 1240                 1245             


Leu Leu  Ala Ser Pro Met Leu  Lys Arg Phe Thr Trp  Thr Asp Ser 
    1250                 1255                 1260             


Lys Pro  Lys Ala Ser Leu Lys  Ile Asp Leu Arg Val  Thr Ser Lys 
    1265                 1270                 1275             


Ser Lys  Glu Ser Gly Leu Ser  Asp Val Ser Arg Pro  Ser Phe Cys 
    1280                 1285                 1290             


His Ser  Ser Cys Gly His Val  Ser Glu Gly Lys Arg  Arg Phe Thr 
    1295                 1300                 1305             


Tyr Asp  His Ala Glu Leu Glu  Arg Lys Ile Ala Cys  Cys Ser Pro 
    1310                 1315                 1320             


Pro Pro  Asp Tyr Asn Ser Val  Val Leu Tyr Ser Thr  Pro Pro Ile 
    1325                 1330                 1335             


<210>  3096
<211>  1352
<212>  DNA
<213>  Homosapiens

<400>  3096
ggggggaaac ggaagtgagc ggcggggtcg actgacggta acggggcaga gaggctgttc     60

gcagagctgc ggaagatgaa tgccagagga cttggatctg agctaaagga cagtattcca    120

gttactgaac tttcagcaag tggacctttt gaaagtcatg atcttcttcg gaaaggtttt    180

tcttgtgtga aaaatgaact tttgcctagt catccccttg aattatcaga aaaaaatttc    240

cagctcaacc aagataaaat gaatttttcc acactgagaa acattcaggg tctatttgct    300

ccgctaaaat tacagatgga attcaaggca gtgcagcagg ttcagcgtct tccatttctt    360

tcaagctcaa atctttcact ggatgttttg aggggtaatg atgagactat tggatttgag    420

gatattctta atgatccatc acaaagcgaa gtcatgggag agccacactt gatggtggaa    480

tataaacttg gtttactgta atagtgtgct gttcatggaa accgagggct gcatcttgtt    540

tatagtcatc tttgtactgt aatttgatgt acacaacatt aaaagtactg acacctgaga    600

atttctgctc aagtagtatc agtgatcatt taaaatttgg aggggtcttt ggtttacagc    660

catgtgacaa ttaaaagcac taaagggaga tcatgttaaa gctcttaatt tatattaaaa    720

cagtagcctt tgtctttaaa aaagttgttg ctcatgaata ttataaaatg atctacaggt    780

ttcaattcaa cctgtttcta ggtttttttg taaatttagt tttgattaag cattataagc    840

atttgagtct ataaacttta tagtagcatc tttcagaata aacattttta attgatttca    900

gtggcaactc tcaaattgat tacaatatga gatatatcag tgtcgtccat taacactcat    960

aagaataata tttactgtgt cagtgctatt ttaggattat agttattgtt tgattatttc   1020

aggttgaaaa gtagaagttc caaggttttg attttggtct ggtctttaag tgaaaaatta   1080

aagcaaccag tagatgtagg ttaaactttt acttcataga cttaatatgt gattaatata   1140

ttgccaagca acactgttaa agaaaagtaa aactcatttt ttcttgttct taatttatat   1200

attacaagat actgtaaggt attctttatg aagttgatat ataaaaattt acatttttag   1260

aacattagtg aatggatcat cttttacaat taaaagtata ttttgattat cagtttctta   1320

gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                 1352


<210>  3097
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  3097

Met Asn Ala Arg Gly Leu Gly Ser Glu Leu Lys Asp Ser Ile Pro Val 
1               5                   10                  15      


Thr Glu Leu Ser Ala Ser Gly Pro Phe Glu Ser His Asp Leu Leu Arg 
            20                  25                  30          


Lys Gly Phe Ser Cys Val Lys Asn Glu Leu Leu Pro Ser His Pro Leu 
        35                  40                  45              


Glu Leu Ser Glu Lys Asn Phe Gln Leu Asn Gln Asp Lys Met Asn Phe 
    50                  55                  60                  


Ser Thr Leu Arg Asn Ile Gln Gly Leu Phe Ala Pro Leu Lys Leu Gln 
65                  70                  75                  80  


Met Glu Phe Lys Ala Val Gln Gln Val Gln Arg Leu Pro Phe Leu Ser 
                85                  90                  95      


Ser Ser Asn Leu Ser Leu Asp Val Leu Arg Gly Asn Asp Glu Thr Ile 
            100                 105                 110         


Gly Phe Glu Asp Ile Leu Asn Asp Pro Ser Gln Ser Glu Val Met Gly 
        115                 120                 125             


Glu Pro His Leu Met Val Glu Tyr Lys Leu Gly Leu Leu 
    130                 135                 140     


<210>  3098
<211>  3467
<212>  DNA
<213>  Homosapiens

<400>  3098
ggcagggcgg cggcggcagc ggcgcagctc cgctccccgc gcgtctccct tccccgcgcc     60

caggtagggc gctcagcctc cgccgccagg atgcggccgc ccgcctgctg gtggctgctc    120

gcgccgccgg cgctgctcgc gctcctcacc tgctccctgg cttttggttt ggcttctgaa    180

gatacaaaga aagaggtcaa gcagtctcag gatttggaga aaagtggtat atcaaggaaa    240

aatgacatag acttaaaagg aattgtattc gtcatccaga gtcaaagtaa ttcttttcat    300

gcaaagagag cagagcagtt aaaaaaaagc atcttaaagc aggctgcaga tcttacacag    360

gagctcccca gtgtcctcct ccttcatcag ctggctaaac aagaaggtgc atggaccata    420

cttccgttgt taccgcactt ttctgtaaca tatagcagaa attcatcttg gattttcttc    480

tgtgaagaag agacaagaat acagattcca aaactcttgg aaaccctcag aagatatgac    540

ccctctaagg aatggttttt gggaaaagca ttacatgatg aagaagctac aataattcac    600

cattatgcct tttccgagaa tcctacagtt tttaagtatc cagactttgc tgcaggctgg    660

gccttaagta ttccacttgt aaacaagctt accaagagac taaagagtga atccttgaaa    720

tccgacttta caatagattt aaaacatgag attgccctct acatctggga caaaggcgga    780

ggacctcccc tgaccccagt gcctgagttt tgtaccaatg acgtggactt ctactgtgct    840

accacattcc attcttttct accgctttgt agaaagccag tgaagaagaa ggatattttt    900

gttgcagtaa aaacatgcaa gaaatttcat ggtgacagaa tgcctattgt taagcagact    960

tgggagagcc aggcaagtct cattgaatac tatagtgact atactgaaaa ttccattcct   1020

actgtggatt tgggaattcc taatacagat agaggtcatt gtggaaagac atttgccatt   1080

ttggaaagat ttctgaatcg tagccaggac aaaacagcat ggttagtcat tgtggatgat   1140

gatacattaa taagtatctc caggctccag cacttgctta gctgttatga ctccggcaag   1200

cctgtgtttc tgggagagcg ctacggctac ggcctgggca ctggtggcta cagctacatc   1260

acgggaggag gaggaatggt cttcagcaga gaagccgtca ggagacttct cgccagtaaa   1320

tgtcgatgct acagcaatga tgctcccgat gatatggtcc tgggaatgtg ctttagtggc   1380

ttgggaatcc ctgtgacaca cagccctctc ttccatcagg ctcggccggt ggattaccct   1440

aaggactacc tttctcatca agttcccata tcgttccaca aacactggaa catcgatcca   1500

gtgaaggtgt atttcacatg gttggcaccc agtgacgaag acaaagccag gcaggagaca   1560

cagaaaggtt ttcgagagga gttataaatc agggtgacct gtgcgcctag cctgctcagg   1620

gagtgaactg gagactgtgg cctcatccca ctgtgctgtg ctcacaacac ttgtgtctgc   1680

cacatggcat tgggtgcttc ctgactttag ggggagattt tatgtatggt attttttgac   1740

agaggaagaa aaggggtcac aggagaaaca tttttttttc tgggaaaaat cacttgcttt   1800

tgacttatgc agttgtttta acacttagtg atgactgtgt attctccaag ctgtgataca   1860

gcagtttttt tttattgtca cagggaaata aatggtacca gaagtccctt tcctgttctg   1920

tctcttcatt gtaatggaag tttcagttgg gcatgagcct ggagagatgt gactgtctac   1980

agttctattt gtatatataa aaagaggact gaaagtcttt tgacatggat attgtgaatg   2040

gtatgaactt ttaaaccata ttattgatga tgaaaattat ttcctgggaa ctcagtagga   2100

ataataccgt attaaggaat aatactgtac ataaaacatc atgaaaccct agatatgaaa   2160

tcccctgaag tctgtaatca tggtggttat gttttgtcta ttcttttgct gtttgtgcct   2220

cataaaaaga gaatgaggtc ttctgctaga gcttcgtatt gctttggaag ttcatctgtg   2280

ttttatttct ccctgaagcc ctatctttat ggcttacttg taacatgaaa gtagtagatg   2340

ctgccagaaa atagtgtcct caatatttaa aacaatgttg acatgttttg ttcaagtcag   2400

caagctctat gtgagtctca ggaagtgaat taaatttgga ccttatgttt tactcttgtt   2460

tttttttttt tttttgaatg ttacttaatg actctctcct gactcaggag agaaacccct   2520

tgtggaagga cagcatggtg atcaggcaat ttctctgggt tcccaaagaa tgacatttga   2580

acacagtatt ttgaaacagc tctagttttc aaattatatc tttaatatat agtaatgtaa   2640

catattcagt attaatgtat aaaaagcact ctaattatat aattcagttt ttgtaaaggt   2700

atttgcataa aatttaatat gtcttaaact aattttggta aattacttct tttttttctt   2760

tttaataaaa actgttactc attaactttg cttataatgc tttttatagc ccagcacaga   2820

atttaaagcc ataccaccaa aagtacctgt gtgtgttaat atgtttttct tgtagcatag   2880

attgactatt tgcaatagta ttagtattta ccatttttcc aaattagcaa ctaccagacc   2940

tcacgtgttg cagtgataac acaatgcatt ggattcagtt ttgtgaaaat ggattctgtg   3000

gccatccaag ggatgtatca gggatgatca gctgatgaga ggctccagaa ggatttctag   3060

atcgcttcaa gcctatactg atggccttag ctttgttcag tcattgtaac tgggattgtt   3120

gtcattgcta ccgtggtagt caccttcatg tcatctataa tagtactcct ggagagccct   3180

ggctgcctac accagtggaa aagagtctcc agttctgctc tggcctacta actgttacca   3240

ctgagagaac aacatgttca tttgacatga ttgaagctgg catccgtata tgaagatcct   3300

tgtcaagctt tcttctgtgg tctgattagt gttgataccg gggcacctcc tctggtactt   3360

ttaagtgttt tgttatttat gtttactttt tggaatggtg taagcctaac cacaaataaa   3420

agatctttgc ctaaaaaaaa aaaaaaaaaa gaaaaaaaaa aaaaaaa                 3467


<210>  3099
<211>  498
<212>  PRT
<213>  Homosapiens

<400>  3099

Met Arg Pro Pro Ala Cys Trp Trp Leu Leu Ala Pro Pro Ala Leu Leu 
1               5                   10                  15      


Ala Leu Leu Thr Cys Ser Leu Ala Phe Gly Leu Ala Ser Glu Asp Thr 
            20                  25                  30          


Lys Lys Glu Val Lys Gln Ser Gln Asp Leu Glu Lys Ser Gly Ile Ser 
        35                  40                  45              


Arg Lys Asn Asp Ile Asp Leu Lys Gly Ile Val Phe Val Ile Gln Ser 
    50                  55                  60                  


Gln Ser Asn Ser Phe His Ala Lys Arg Ala Glu Gln Leu Lys Lys Ser 
65                  70                  75                  80  


Ile Leu Lys Gln Ala Ala Asp Leu Thr Gln Glu Leu Pro Ser Val Leu 
                85                  90                  95      


Leu Leu His Gln Leu Ala Lys Gln Glu Gly Ala Trp Thr Ile Leu Pro 
            100                 105                 110         


Leu Leu Pro His Phe Ser Val Thr Tyr Ser Arg Asn Ser Ser Trp Ile 
        115                 120                 125             


Phe Phe Cys Glu Glu Glu Thr Arg Ile Gln Ile Pro Lys Leu Leu Glu 
    130                 135                 140                 


Thr Leu Arg Arg Tyr Asp Pro Ser Lys Glu Trp Phe Leu Gly Lys Ala 
145                 150                 155                 160 


Leu His Asp Glu Glu Ala Thr Ile Ile His His Tyr Ala Phe Ser Glu 
                165                 170                 175     


Asn Pro Thr Val Phe Lys Tyr Pro Asp Phe Ala Ala Gly Trp Ala Leu 
            180                 185                 190         


Ser Ile Pro Leu Val Asn Lys Leu Thr Lys Arg Leu Lys Ser Glu Ser 
        195                 200                 205             


Leu Lys Ser Asp Phe Thr Ile Asp Leu Lys His Glu Ile Ala Leu Tyr 
    210                 215                 220                 


Ile Trp Asp Lys Gly Gly Gly Pro Pro Leu Thr Pro Val Pro Glu Phe 
225                 230                 235                 240 


Cys Thr Asn Asp Val Asp Phe Tyr Cys Ala Thr Thr Phe His Ser Phe 
                245                 250                 255     


Leu Pro Leu Cys Arg Lys Pro Val Lys Lys Lys Asp Ile Phe Val Ala 
            260                 265                 270         


Val Lys Thr Cys Lys Lys Phe His Gly Asp Arg Met Pro Ile Val Lys 
        275                 280                 285             


Gln Thr Trp Glu Ser Gln Ala Ser Leu Ile Glu Tyr Tyr Ser Asp Tyr 
    290                 295                 300                 


Thr Glu Asn Ser Ile Pro Thr Val Asp Leu Gly Ile Pro Asn Thr Asp 
305                 310                 315                 320 


Arg Gly His Cys Gly Lys Thr Phe Ala Ile Leu Glu Arg Phe Leu Asn 
                325                 330                 335     


Arg Ser Gln Asp Lys Thr Ala Trp Leu Val Ile Val Asp Asp Asp Thr 
            340                 345                 350         


Leu Ile Ser Ile Ser Arg Leu Gln His Leu Leu Ser Cys Tyr Asp Ser 
        355                 360                 365             


Gly Lys Pro Val Phe Leu Gly Glu Arg Tyr Gly Tyr Gly Leu Gly Thr 
    370                 375                 380                 


Gly Gly Tyr Ser Tyr Ile Thr Gly Gly Gly Gly Met Val Phe Ser Arg 
385                 390                 395                 400 


Glu Ala Val Arg Arg Leu Leu Ala Ser Lys Cys Arg Cys Tyr Ser Asn 
                405                 410                 415     


Asp Ala Pro Asp Asp Met Val Leu Gly Met Cys Phe Ser Gly Leu Gly 
            420                 425                 430         


Ile Pro Val Thr His Ser Pro Leu Phe His Gln Ala Arg Pro Val Asp 
        435                 440                 445             


Tyr Pro Lys Asp Tyr Leu Ser His Gln Val Pro Ile Ser Phe His Lys 
    450                 455                 460                 


His Trp Asn Ile Asp Pro Val Lys Val Tyr Phe Thr Trp Leu Ala Pro 
465                 470                 475                 480 


Ser Asp Glu Asp Lys Ala Arg Gln Glu Thr Gln Lys Gly Phe Arg Glu 
                485                 490                 495     


Glu Leu 
        


<210>  3100
<211>  2887
<212>  DNA
<213>  Homosapiens

<400>  3100
gagactaggg ggcggcgagg agtgggaccc gctcgcggcc attggttgtg cggccaggag     60

gggcggaggg acgacgcgcg ggctgtgcgg ggccggcagc ccggatccac tcccgctgcg    120

cctgctgtcc gccgtgcgcc cagactgcgc gccgcgccgc tgcgcccaac attcccgagg    180

acggcttcgc gggcgcgtat cgtccagacc ggagcaccgc cccaccgcta gcgcaggaga    240

cctgccgggg aagtcgcgtg tcctgacctg cagtctcaat gcacatctga tacctgctgc    300

ctttgagaaa caagttttgt tgtgctgatt taacagcctg tgaattctgc aaacacgatc    360

gtgaaaaaat gccaatctgt cctgtgtaag ccctgtgtga agttttgact ttaatctacc    420

agatcactcc ttcaccctcc ataaagatgt ctgaacctga cacttcctca ggattttcgg    480

gaagtgtgga gaatggaact tttcttgagc tgtttcccac atccctgtcc acgtcagtgg    540

acccatcctc aggccacctg tcaaacgtct acatctatgt gtccatattc ctcagccttt    600

tagcgtttct gcttctgctt ttaatcattg ccctccagag gctcaaaaat atcatctcct    660

ccagttcctc ctacccaggg tatccaagcg acgctggaag ttctttcacc aatttggaag    720

tctgcagcat ttcctctcag aggtccactt tttcaaacct ttcatcctga ggaaaatgga    780

agagtccttg agtgtggcag cagttttgac atccccttac ggaagtgtcc cgtgaggcat    840

tgcctcatga aagaaatgat ccttttggtg tagacctgct tctccttctc ctttttctct    900

gatttctttt ctgttcatga tgcttttcat ttggggatgg agacaccgat gttggtggaa    960

atgtgtgcaa accccaaggt gcagaatttc acacaaatgg cttgatgaat ctagactggg   1020

cttcttcagg taagtcagtt cattctactt tgttggacgc cgtagactca tctgaggtgg   1080

cctctccgtg gatgctggac atggactcgc acttcatttc ttttacaaag ccgtgaaatc   1140

aactgagcct gcagaaactg gcaaaatcaa gtctgaccta tgtagaagtt attttccata   1200

tttaaaagat aaagtggaga caccaaactt aaaaaggaag agagtcaatt tagatttaat   1260

gtatgacatt tctaaaactg agggtaaata tatgctaaat attttcttta acttcacttt   1320

aacaagtaaa aatcacactt attgatgaat gtaagtcatt tgggaaagtt ttggaagagt   1380

ttacatttta atagcaagac aaacatgtat tatgatggag cttgtgatgt atttctgcct   1440

cctggagttt tattttgttt ttctgcttat gttttagtca taatgccaca aagttgtgga   1500

atttttgtga ttaattgctg ttactagtac taagagaagc accagaagag atgccaagaa   1560

gtttttatat gaataatttc tatcagtgag aattaagcat atggaaaata ttcatttagt   1620

tgtattttat acagtaataa ctcttagctg tcgtgtaagt tcctttattc ggtttcatag   1680

tctttataat tttagtgcag aattatatta agcctccaag atgtctgata tttgttcact   1740

cacattaggt tgtaaaactt agaaactaaa ttgcaaatat atgtgttatt atatactcca   1800

cgaatgttgc gtctctgata attagttgtt gtatgttaac ataatactct acattaggat   1860

ttcaggatgt gagtttgtat taaaaattgt aggcactcaa gttgtgtagc tgctgggagc   1920

tttagggatc ctaggagctg ccgtgctgca ggcagcagag tatgtctgaa ctcggcgggc   1980

gggtggcagg ggctgtctgt gaaattaggc acacatgtga gctcagacat ggaatgtgga   2040

ggaactcaag ctgcccctaa aaacaaaaca atcaaactgc agctccttaa gagtaagaat   2100

tttaatttaa ttttgaaaat aaatggccca cagggtaaac actgaactta ttcaacctac   2160

aggaggccac tgcatcaaca cgccacggtc ttcccatggc aactgaatca ttccttgttc   2220

aaaacattta atcatcttaa gcagtggggc ttcaacacac cgtttggtta gattgtgcag   2280

tcagcactct ccagtgatta gaatggggga aagaatccac tatttgtaca gggtttatct   2340

ttatcatact aaaatgctga gtgagtggag gtctgggaat gaaaatcaga agtcttcttc   2400

ttcttttaat tcataagcct cacttaaatc agaacacatt taactattta tatatcaaaa   2460

acgtccccaa acaccataag accagcacag agttgctgcc ctaaaatgta taattagtga   2520

aaaatttacc tctgcttcca tttaaagcat ggcagtgggt tgggtgtcat tatgtagtat   2580

aaaaactgga ctagataaac tgctatttta gagcattatt agcattctct gaatatatgt   2640

atatatacat atatatacgc acacacacac acacataaat atatatatat atatatatat   2700

aaactcacat actcccaatt aaaagtcgtg tgaaagctac acaggattac agaggcatct   2760

atattatcac ttttgctctt tgactaatcc tatgctgttt ttgttataga gagaaacaag   2820

gacatggatg aagtgatttt ttttttaaat aaaaggacaa atttgccaca caaaaaaaaa   2880

aaaaaaa                                                             2887


<210>  3101
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  3101

Met Ser Glu Pro Asp Thr Ser Ser Gly Phe Ser Gly Ser Val Glu Asn 
1               5                   10                  15      


Gly Thr Phe Leu Glu Leu Phe Pro Thr Ser Leu Ser Thr Ser Val Asp 
            20                  25                  30          


Pro Ser Ser Gly His Leu Ser Asn Val Tyr Ile Tyr Val Ser Ile Phe 
        35                  40                  45              


Leu Ser Leu Leu Ala Phe Leu Leu Leu Leu Leu Ile Ile Ala Leu Gln 
    50                  55                  60                  


Arg Leu Lys Asn Ile Ile Ser Ser Ser Ser Ser Tyr Pro Gly Tyr Pro 
65                  70                  75                  80  


Ser Asp Ala Gly Ser Ser Phe Thr Asn Leu Glu Val Cys Ser Ile Ser 
                85                  90                  95      


Ser Gln Arg Ser Thr Phe Ser Asn Leu Ser Ser 
            100                 105         


<210>  3102
<211>  2825
<212>  DNA
<213>  Homosapiens

<400>  3102
cgcgcaggct gcggtcgcgc aggcgcagtc ggggcgcctt cccggtatag gcgcctttta     60

ccccagcgtg tcctgagtct ttggttcgcg aagtgccgtt aggccaagca ggtgctaaaa    120

gcccggggtc gtggaccccg gccaggtctt agcagcatgg aggcgcaggg tgtagcggag    180

ggcgcggggc cgggcgccgc cagcggcgtg ccccaccccg cggccctagc cccggctgcg    240

gctcccacct tggcgccagc ctcggtggcg gccgcggcct ctcaattcac cctgctagtg    300

atgcaaccct gtgctgggca ggacgaggct gcggcccccg ggggcagcgt tggggcgggc    360

aagcccgtta ggtacctgtg cgaaggggcc ggggatggcg aagaggaggc tggggaggac    420

gaggcggacc tgttagacac ttcggaccct ccggggggag gcgagagcgc ggctagtttg    480

gaggatctag aggacgagga gactcactcg gggggcgagg gcagcagcgg gggcgcccgg    540

aggcggggca gcggtggggg cagcatgagc aagacctgca cctacgaagg ctgcagcgag    600

accacgagcc aggtggccaa gcagcgcaaa ccgtggatgt gcaagaaaca ccgcaacaag    660

atgtacaagg acaagtataa aaagaagaag agcgaccagg ccctgaactg cggtgggact    720

gcctcgactg gcagcgcggg aaacgtcaaa ctcgaggaaa gtgcagataa catactctcc    780

attgttaaac aaagaacagg atcttttggg gatcgtcctg caagacctac tcttttagaa    840

caagtgttaa atcaaaaaag actgtcgtta ctaagaagtc cagaagtagt gcaattttta    900

cagaaacagc aacagctatt aaatcagcaa gttttggagc aaagacaaca gcagtttcca    960

ggaacatcaa tgtgagggaa cttaccaaga acatctacat ggtttttatc ttattgtaat   1020

agatgagcat atttttttac cagacataaa tggggtaata atctatgcct gtagaacata   1080

aacattttcc tgtaaatgta tgtgtgcatt tggggataag taagtattgc actttgtgca   1140

tctaatcttt cagattactg tgagtttgaa gaagtcagct tatctttcca aataacattt   1200

aattataatg ttttttaaaa aatatattcc tcttcagtca ttgttactga aggtaatgaa   1260

gcagttactt tctgtggaag tcataaagtt aatagatatt aatcttgact catctagctc   1320

agtggttctc atcaagggtc aatttgattg tcatagtgac cttgaaaacc actggctttt   1380

agtgagtggc caggaaatgc taaatgttct gcagtgtcag gggtagtccc acatactaaa   1440

gattgtctca cccgcagtgc caataacact cctaagaaat gttgatggct attttgtggt   1500

gctaacatgt agttggggca cctacaattg ggttctctta ataacctttc tttgcagtta   1560

agactgaagc tgtcaaagag gtaagcacat tttatataga cgtaaggaaa gtgattattg   1620

tttaatatct gtgaatttag gatgtgcatc tcttttcaga ggtgtgttag taaaacctga   1680

cggattaact aagcacactg ggatgtgtct cctacagttg gcttctctct ttgatgttac   1740

ctgttagtgc tgatctctta aagcagacat ttcttgtttg ttgaatttgt gaacagtata   1800

gatctcagcc caccaatgcc aagacaaaat tatttttctt atacttattt tttattaaac   1860

aaaatgaaaa agatcctttt caaaaaggtg atcctgaaaa taaaactaac actccagtat   1920

tttgtcattg tttttcgcaa ttgagctatc tgaaaactgt tattcctaag taatgttcaa   1980

aaatgataag taatctggat acctttttct tatactttct cctaggaaaa ctttaaaact   2040

ttaaaaaggc aaacctacca ataggaataa caaattaaat gtcaagagag tatatccaat   2100

attaggatat aaatgtatgt gtctcaagtt taactctaca aaaatttgtt acttgttttt   2160

taaactctat atataaagtt cgacttaatc atggctgttc taagaagtac ttatggagag   2220

caagaacatt tttgttcatt tcttaatgtg tgtgttttta cttgcatatc tgttcaaaac   2280

acttttaaca aaattaattc attaaagtcc agttgttgac ctttgagtta gctgatttct   2340

ttattctgtt ctttagttta ttcttactag atgcagagga attcatctac tgtctgttat   2400

taactgttag tttattctca tacttacgat gttgagagtt tttttgaagc ttaagttacc   2460

ctttatggtg gaaaacatta gcttatgctt ctttagatgg aataatggga aaggagggaa   2520

atgggaaatg gatggaaatg ggaaaggagg gaaaataata gcccagtgag agctgaatga   2580

aaagggactg aatttaaata tttgtaagaa ctttgtgatg atgagtaatt gtcagacgtg   2640

ggatagataa ctgagaggct cagaatcttt accaaggata ttttttagga taaggtagct   2700

gcctgttcat gaatttggat aagaatagta ggacaatatt caacacaatt taatttttgt   2760

ctgccacatt agacattttt ttaccttata aaatgatcaa taaagcaata aggtttattt   2820

tgggt                                                               2825


<210>  3103
<211>  272
<212>  PRT
<213>  Homosapiens

<400>  3103

Met Glu Ala Gln Gly Val Ala Glu Gly Ala Gly Pro Gly Ala Ala Ser 
1               5                   10                  15      


Gly Val Pro His Pro Ala Ala Leu Ala Pro Ala Ala Ala Pro Thr Leu 
            20                  25                  30          


Ala Pro Ala Ser Val Ala Ala Ala Ala Ser Gln Phe Thr Leu Leu Val 
        35                  40                  45              


Met Gln Pro Cys Ala Gly Gln Asp Glu Ala Ala Ala Pro Gly Gly Ser 
    50                  55                  60                  


Val Gly Ala Gly Lys Pro Val Arg Tyr Leu Cys Glu Gly Ala Gly Asp 
65                  70                  75                  80  


Gly Glu Glu Glu Ala Gly Glu Asp Glu Ala Asp Leu Leu Asp Thr Ser 
                85                  90                  95      


Asp Pro Pro Gly Gly Gly Glu Ser Ala Ala Ser Leu Glu Asp Leu Glu 
            100                 105                 110         


Asp Glu Glu Thr His Ser Gly Gly Glu Gly Ser Ser Gly Gly Ala Arg 
        115                 120                 125             


Arg Arg Gly Ser Gly Gly Gly Ser Met Ser Lys Thr Cys Thr Tyr Glu 
    130                 135                 140                 


Gly Cys Ser Glu Thr Thr Ser Gln Val Ala Lys Gln Arg Lys Pro Trp 
145                 150                 155                 160 


Met Cys Lys Lys His Arg Asn Lys Met Tyr Lys Asp Lys Tyr Lys Lys 
                165                 170                 175     


Lys Lys Ser Asp Gln Ala Leu Asn Cys Gly Gly Thr Ala Ser Thr Gly 
            180                 185                 190         


Ser Ala Gly Asn Val Lys Leu Glu Glu Ser Ala Asp Asn Ile Leu Ser 
        195                 200                 205             


Ile Val Lys Gln Arg Thr Gly Ser Phe Gly Asp Arg Pro Ala Arg Pro 
    210                 215                 220                 


Thr Leu Leu Glu Gln Val Leu Asn Gln Lys Arg Leu Ser Leu Leu Arg 
225                 230                 235                 240 


Ser Pro Glu Val Val Gln Phe Leu Gln Lys Gln Gln Gln Leu Leu Asn 
                245                 250                 255     


Gln Gln Val Leu Glu Gln Arg Gln Gln Gln Phe Pro Gly Thr Ser Met 
            260                 265                 270         


<210>  3104
<211>  1943
<212>  DNA
<213>  Homosapiens

<400>  3104
gcaacttgaa ttggtcccag ctgctcccag aagaacgggc gggttggtcc ctatgccacc     60

cctggagagc tactcgccgc ccactttgcc gtgaagggct gtgcggttcc cgtgcgcgcc    120

ggagcctgct gtggcctctt atgcactcca ccacccccat cagctccctc ttctccttca    180

ccagccccgc agtgaagaga ctgctaggct ggaagcaagg agatgaagag gaaaagtggg    240

cagagaaggc agtggactct ctagtgaaga agttaaagaa gaagaaggga gccatggacg    300

agctggagag ggctctcagc tgcccggggc agcccagcaa atgcgtcacg attccccgct    360

ccctggacgg gcggctgcag gtgtcccacc gcaagggcct gccccatgtg atttactgtc    420

gcgtgtggcg ctggccggat ctgcagtccc accacgagct gaagccgctg gagtgctgtg    480

agttcccatt tggctccaag cagaaagaag tgtgcattaa cccttaccac taccgccggg    540

tggagactcc agtactgcct cctgtgctcg tgccaagaca cagtgaatat aacccccagc    600

tcagcctcct ggccaagttc cgcagcgcct ccctgcacag tgagccactc atgccacaca    660

acgccaccta tcctgactct ttccagcagc ctccgtgctc tgcactccct ccctcaccca    720

gccacgcgtt ctcccagtcc ccgtgcacgg ccagctaccc tcactcccca ggaagtcctt    780

ctgagccaga gagtccctat caacactcag actttcgacc agtttgttac gaggagcccc    840

agcactggtg ctcggtcgcc tactatgaac tgaacaaccg agttggggag acattccagg    900

cttcctcccg aagtgtgctc atagatgggt tcaccgaccc ttcaaataac aggaacagat    960

tctgtcttgg acttctttct aatgtaaaca gaaactcaac gatagaaaat accaggagac   1020

atataggaaa gggtgtgcac ttgtactacg tcgggggaga ggtgtatgcc gagtgcgtga   1080

gtgacagcag catctttgtg cagagccgga actgcaacta tcaacacggc ttccacccag   1140

ctaccgtctg caagatcccc agcggctgca gcctcaaggt cttcaacaac cagctcttcg   1200

ctcagctcct ggcccagtca gttcaccacg gctttgaagt cgtgtatgaa ctgaccaaga   1260

tgtgtactat ccggatgagt tttgttaagg gttggggtgc tgagtatcat cgccaggatg   1320

tcaccagcac cccctgctgg attgagattc atcttcatgg gccactgcag tggctggaca   1380

aagttctgac tcagatgggc tctccacata accccatttc ttcagtgtct taacagtcat   1440

gtcttaagct gcatttccat aggatagagg ctattgcagg gagtggcttg tatcatttca   1500

gatttgcaac tgaagtttct aaaaacatgt gtaaatacat agaatgtata ctgttcttat   1560

tttttttaat caccgtttgt tttgtgcttt ctagttaacc tgatgccagt acagtgcaat   1620

tggaaaagca ggactttggt gcctgtgcta taagcagcag attttgtggg aggaaacact   1680

tgagaggcga tattgtcaac agtatttgaa gggtgttagc agaataaaag acagctttag   1740

tcagccgtgt cattataaag catgttgtgt ggcctcacag aaacattgaa actgtttata   1800

cagcaaaagt caggtattag cagcactaaa gcaaatatca ctcagatgaa acaaagcagt   1860

gaaaccctac agtttaaatg atgtcacttt tagtgctgtt ggcaagaaaa aaaaaaaaaa   1920

aaaccaaaaa aaaaaaaaaa aaa                                           1943


<210>  3105
<211>  430
<212>  PRT
<213>  Homosapiens

<400>  3105

Met His Ser Thr Thr Pro Ile Ser Ser Leu Phe Ser Phe Thr Ser Pro 
1               5                   10                  15      


Ala Val Lys Arg Leu Leu Gly Trp Lys Gln Gly Asp Glu Glu Glu Lys 
            20                  25                  30          


Trp Ala Glu Lys Ala Val Asp Ser Leu Val Lys Lys Leu Lys Lys Lys 
        35                  40                  45              


Lys Gly Ala Met Asp Glu Leu Glu Arg Ala Leu Ser Cys Pro Gly Gln 
    50                  55                  60                  


Pro Ser Lys Cys Val Thr Ile Pro Arg Ser Leu Asp Gly Arg Leu Gln 
65                  70                  75                  80  


Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr Cys Arg Val Trp 
                85                  90                  95      


Arg Trp Pro Asp Leu Gln Ser His His Glu Leu Lys Pro Leu Glu Cys 
            100                 105                 110         


Cys Glu Phe Pro Phe Gly Ser Lys Gln Lys Glu Val Cys Ile Asn Pro 
        115                 120                 125             


Tyr His Tyr Arg Arg Val Glu Thr Pro Val Leu Pro Pro Val Leu Val 
    130                 135                 140                 


Pro Arg His Ser Glu Tyr Asn Pro Gln Leu Ser Leu Leu Ala Lys Phe 
145                 150                 155                 160 


Arg Ser Ala Ser Leu His Ser Glu Pro Leu Met Pro His Asn Ala Thr 
                165                 170                 175     


Tyr Pro Asp Ser Phe Gln Gln Pro Pro Cys Ser Ala Leu Pro Pro Ser 
            180                 185                 190         


Pro Ser His Ala Phe Ser Gln Ser Pro Cys Thr Ala Ser Tyr Pro His 
        195                 200                 205             


Ser Pro Gly Ser Pro Ser Glu Pro Glu Ser Pro Tyr Gln His Ser Asp 
    210                 215                 220                 


Phe Arg Pro Val Cys Tyr Glu Glu Pro Gln His Trp Cys Ser Val Ala 
225                 230                 235                 240 


Tyr Tyr Glu Leu Asn Asn Arg Val Gly Glu Thr Phe Gln Ala Ser Ser 
                245                 250                 255     


Arg Ser Val Leu Ile Asp Gly Phe Thr Asp Pro Ser Asn Asn Arg Asn 
            260                 265                 270         


Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn Arg Asn Ser Thr Ile 
        275                 280                 285             


Glu Asn Thr Arg Arg His Ile Gly Lys Gly Val His Leu Tyr Tyr Val 
    290                 295                 300                 


Gly Gly Glu Val Tyr Ala Glu Cys Val Ser Asp Ser Ser Ile Phe Val 
305                 310                 315                 320 


Gln Ser Arg Asn Cys Asn Tyr Gln His Gly Phe His Pro Ala Thr Val 
                325                 330                 335     


Cys Lys Ile Pro Ser Gly Cys Ser Leu Lys Val Phe Asn Asn Gln Leu 
            340                 345                 350         


Phe Ala Gln Leu Leu Ala Gln Ser Val His His Gly Phe Glu Val Val 
        355                 360                 365             


Tyr Glu Leu Thr Lys Met Cys Thr Ile Arg Met Ser Phe Val Lys Gly 
    370                 375                 380                 


Trp Gly Ala Glu Tyr His Arg Gln Asp Val Thr Ser Thr Pro Cys Trp 
385                 390                 395                 400 


Ile Glu Ile His Leu His Gly Pro Leu Gln Trp Leu Asp Lys Val Leu 
                405                 410                 415     


Thr Gln Met Gly Ser Pro His Asn Pro Ile Ser Ser Val Ser 
            420                 425                 430 


<210>  3106
<211>  3213
<212>  DNA
<213>  Homosapiens

<400>  3106
agagactcaa gatgattccc tttttaccca tgttttctct actattgctg cttattgtta     60

accctataaa cgccaacaat cattatgaca agatcttggc tcatagtcgt atcaggggtc    120

gggaccaagg cccaaatgtc tgtgcccttc aacagatttt gggcaccaaa aagaaatact    180

tcagcacttg taagaactgg tataaaaagt ccatctgtgg acagaaaacg actgttttat    240

atgaatgttg ccctggttat atgagaatgg aaggaatgaa aggctgccca gcagttttgc    300

ccattgacca tgtttatggc actctgggca tcgtgggagc caccacaacg cagcgctatt    360

ctgacgcctc aaaactgagg gaggagatcg agggaaaggg atccttcact tactttgcac    420

cgagtaatga ggcttgggac aacttggatt ctgatatccg tagaggtttg gagagcaacg    480

tgaatgttga attactgaat gctttacata gtcacatgat taataagaga atgttgacca    540

aggacttaaa aaatggcatg attattcctt caatgtataa caatttgggg cttttcatta    600

accattatcc taatggggtt gtcactgtta attgtgctcg aatcatccat gggaaccaga    660

ttgcaacaaa tggtgttgtc catgtcattg accgtgtgct tacacaaatt ggtacctcaa    720

ttcaagactt cattgaagca gaagatgacc tttcatcttt tagagcagct gccatcacat    780

cggacatatt ggaggccctt ggaagagacg gtcacttcac actctttgct cccaccaatg    840

aggcttttga gaaacttcca cgaggtgtcc tagaaaggtt catgggagac aaagtggctt    900

ccgaagctct tatgaagtac cacatcttaa atactctcca gtgttctgag tctattatgg    960

gaggagcagt ctttgagacg ctggaaggaa atacaattga gataggatgt gacggtgaca   1020

gtataacagt aaatggaatc aaaatggtga acaaaaagga tattgtgaca aataatggtg   1080

tgatccattt gattgatcag gtcctaattc ctgattctgc caaacaagtt attgagctgg   1140

ctggaaaaca gcaaaccacc ttcacggatc ttgtggccca attaggcttg gcatctgctc   1200

tgaggccaga tggagaatac actttgctgg cacctgtgaa taatgcattt tctgatgata   1260

ctctcagcat ggttcagcgc ctccttaaat taattctgca gaatcacata ttgaaagtaa   1320

aagttggcct taatgagctt tacaacgggc aaatactgga aaccatcgga ggcaaacagc   1380

tcagagtctt cgtatatcgt acagctgtct gcattgaaaa ttcatgcatg gagaaaggga   1440

gtaagcaagg gagaaacggt gcgattcaca tattccgcga gatcatcaag ccagcagaga   1500

aatccctcca tgaaaagtta aaacaagata agcgctttag caccttcctc agcctacttg   1560

aagctgcaga cttgaaagag ctcctgacac aacctggaga ctggacatta tttgtgccaa   1620

ccaatgatgc ttttaaggga atgactagtg aagaaaaaga aattctgata cgggacaaaa   1680

atgctcttca aaacatcatt ctttatcacc tgacaccagg agttttcatt ggaaaaggat   1740

ttgaacctgg tgttactaac attttaaaga ccacacaagg aagcaaaatc tttctgaaag   1800

aagtaaatga tacacttctg gtgaatgaat tgaaatcaaa agaatctgac atcatgacaa   1860

caaatggtgt aattcatgtt gtagataaac tcctctatcc agcagacaca cctgttggaa   1920

atgatcaact gctggaaata cttaataaat taatcaaata catccaaatt aagtttgttc   1980

gtggtagcac cttcaaagaa atccccgtga ctgtctatac aactaaaatt ataaccaaag   2040

ttgtggaacc aaaaattaaa gtgattgaag gcagtcttca gcctattatc aaaactgaag   2100

gacccacact aacaaaagtc aaaattgaag gtgaacctga attcagactg attaaagaag   2160

gtgaaacaat aactgaagtg atccatggag agccaattat taaaaaatac accaaaatca   2220

ttgatggagt gcctgtggaa ataactgaaa aagagacacg agaagaacga atcattacag   2280

gtcctgaaat aaaatacact aggatttcta ctggaggtgg agaaacagaa gaaactctga   2340

agaaattgtt acaagaagag gtcaccaagg tcaccaaatt cattgaaggt ggtgatggtc   2400

atttatttga agatgaagaa attaaaagac tgcttcaggg agacacaccc gtgaggaagt   2460

tgcaagccaa caaaaaagtt caaggttcta gaagacgatt aagggaaggt cgttctcagt   2520

gaaaatccaa aaaccagaaa aaaatgttta tacaacccta agtcaataac ctgaccttag   2580

aaaattgtga gagccaagtt gacttcagga actgaaacat cagcacaaag aagcaatcat   2640

caaataattc tgaacacaaa tttaatattt ttttttctga atgagaaaca tgagggaaat   2700

tgtggagtta gcctcctgtg gtaaaggaat tgaagaaaat ataacacctt acaccctttt   2760

tcatcttgac attaaaagtt ctggctaact ttggaatcca ttagagaaaa atccttgtca   2820

ccagattcat tacaattcaa atcgaagagt tgtgaactgt tatcccattg aaaagaccga   2880

gccttgtatg tatgttatgg atacataaaa tgcacgcaag ccattatctc tccatgggaa   2940

gctaagttat aaaaataggt gcttggtgta caaaactttt tatatcaaaa ggctttgcac   3000

atttctatat gagtgggttt actggtaaat tatgttattt tttacaacta attttgtact   3060

ctcagaatgt ttgtcatatg cttcttgcaa tgcatatttt ttaatctcaa acgtttcaat   3120

aaaaccattt ttcagatata aagagaatta cttcaaattg agtaattcag aaaaactcaa   3180

gatttaagtt aaaaagtggt ttggacttgg gaa                                3213


<210>  3107
<211>  836
<212>  PRT
<213>  Homosapiens

<400>  3107

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Phe Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Val Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Thr Thr Lys 
            660                 665                 670         


Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Glu Gly Ser 
        675                 680                 685             


Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr Leu Thr Lys Val Lys 
    690                 695                 700                 


Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys Glu Gly Glu Thr Ile 
705                 710                 715                 720 


Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys Lys Tyr Thr Lys Ile 
                725                 730                 735     


Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu 
            740                 745                 750         


Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly 
        755                 760                 765             


Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val 
    770                 775                 780                 


Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu 
785                 790                 795                 800 


Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys 
                805                 810                 815     


Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu 
            820                 825                 830         


Gly Arg Ser Gln 
        835     


<210>  3108
<211>  1154
<212>  DNA
<213>  Homosapiens

<400>  3108
cttcccctca tcagctatgt gacaagaagt cactaaactt ttctatatct cggcttcttt     60

attaataaaa tgagaggtgg gattaggtta cctccaaggt tttaacattc tttgatctta    120

tacaaatgcc agtgaagaag catttttatt tttaataaca ctttcctctt cagatggcca    180

agttattgtg attgaaggca ttccaggaaa caggaaacag tggcggcatg aagctccagg    240

aactttaatg agtgttttgg cagcagcaca tctaacgagt agctcatttt ctgccgatga    300

agaatttgca atgggaacat taaaacaatg gctacccaaa gaagaagatg aagggaaggt    360

agaaatggtc tctggcattg aagtagatga ggaacaacta gaaccaagat ctgatgatga    420

tgatacaaat tttgaagaat ctgaagatga gttgagagat gaagtagtag aatacttaga    480

aaaactcgct actttcaaag gggaagaaaa aacagaagag gcctccagta cctctaagga    540

ctctagaaag tcaagagaaa gagaggggat aagtatgcag aaatctgaag aattaaggga    600

gggcttggag aatatttcta ctacatctaa tgaccacatt tgtattactg atgaagacca    660

aggaacatca acaaccagtc aaaatataca agtgtgatta ttgtactttt tcttaagtaa    720

taagttagtg tctattacct atagtattta tttgggtaca agtcataaat gctcatttac    780

tgtaagggtt ttctagtaat ctcaaggatt tattaatttt tctttcaatt taggaagtag    840

aacttttgaa tatagccatt aatattttta ctttaaagtt tctattaaga aatcttaggc    900

cgggcagtct catcactttg ggaggccaag gcaggcagat catgaggtca ggagtttgag    960

accagtccaa ccaacatggt gaaaccccgt ctctactaaa aatacaaaat tagctgggca   1020

tggtggtgca tgcctgtaat cccagttact tgggaggctg aggcaggaga atcacctgaa   1080

cccaggagat ggaagttgca agtgagccga gattgtgcca ctgcactcca gcctgggcaa   1140

caagagcgaa actc                                                     1154


<210>  3109
<211>  149
<212>  PRT
<213>  Homosapiens

<400>  3109

Met Ser Val Leu Ala Ala Ala His Leu Thr Ser Ser Ser Phe Ser Ala 
1               5                   10                  15      


Asp Glu Glu Phe Ala Met Gly Thr Leu Lys Gln Trp Leu Pro Lys Glu 
            20                  25                  30          


Glu Asp Glu Gly Lys Val Glu Met Val Ser Gly Ile Glu Val Asp Glu 
        35                  40                  45              


Glu Gln Leu Glu Pro Arg Ser Asp Asp Asp Asp Thr Asn Phe Glu Glu 
    50                  55                  60                  


Ser Glu Asp Glu Leu Arg Asp Glu Val Val Glu Tyr Leu Glu Lys Leu 
65                  70                  75                  80  


Ala Thr Phe Lys Gly Glu Glu Lys Thr Glu Glu Ala Ser Ser Thr Ser 
                85                  90                  95      


Lys Asp Ser Arg Lys Ser Arg Glu Arg Glu Gly Ile Ser Met Gln Lys 
            100                 105                 110         


Ser Glu Glu Leu Arg Glu Gly Leu Glu Asn Ile Ser Thr Thr Ser Asn 
        115                 120                 125             


Asp His Ile Cys Ile Thr Asp Glu Asp Gln Gly Thr Ser Thr Thr Ser 
    130                 135                 140                 


Gln Asn Ile Gln Val 
145                 


<210>  3110
<211>  2332
<212>  DNA
<213>  Homosapiens

<400>  3110
ttcacttaac ctgcagacag aactcagtta gtcggggaca atttccctca atgttaacag     60

cactgttcca ccgcaacgtg gaacaacagc tttaaaacgt gctcttcgta ggcccggcta    120

ctccaagaac agtgcctccc gccagaccca ggcggcttcc ttcacccgca acccgagaga    180

cgacccgccg ggcccgcccc gcggaagccg ccggttgcca ggccaaggag tggactaggg    240

tcgccgggga agcggtttgg gagagcccat ggtgactgcg tgagtggagc ccagctgtgt    300

ggatgcccca gcatggatga ctacatggtc ctgagaatga ttggggaggg ctccttcggc    360

agagctcttt tggttcagca tgaaagcagt aatcagatgt ttgccatgaa agaaataagg    420

cttcccaagt ctttctctaa tacacagaat tctaggaagg aggctgttct tttagccaaa    480

atgaaacacc ctaatattgt tgccttcaaa gaatcatttg aagctgaagg acacttgtat    540

attgtgatgg aatactgtga tggaggggat ctaatgcaaa agattaaaca gcagaaagga    600

aagttatttc ctgaagacat gatacttaat tggtttaccc aaatgtgcct tggagtaaat    660

cacattcaca agaaacgtgt gctacacaga gatatcaagt ccaagaatat cttcctcact    720

cagaatggaa aagtgaaatt gggagacttt ggatctgccc gtcttctctc caatccgatg    780

gcatttgctt gtacctatgt gggaactcct tattatgtgc ctccagaaat ttgggaaaac    840

ctgccttata acaataaaag tgacatctgg tccttgggtt gcatcctgta tgaactctgt    900

acccttaagc atccatttca ggcaaatagt tggaaaaatc ttatcctcaa agtatgtcaa    960

gggtgcatca gtccactgcc gtctcattac tcctatgaac ttcagttcct agtcaagcag   1020

atgtttaaaa ggaatccctc acatcgcccc tcggctacaa cgcttctctc tcgaggcatc   1080

gtagctcggc ttgtccagaa gtgcttaccc cccgagatca tcatggaata tggtgaggaa   1140

gtattagaag aaataaaaaa ttcgaagcat aacacaccaa gaaaaaaaac aaaccccagc   1200

agaatcagga tagctttggg aaatgaagca agcacagtgc aagaggaaga acaagataga   1260

aagggtagcc atactgattt ggaaagcatt aatgaaaatt tagttgaaag tgcattgaga   1320

agagtaaaca gagaagaaaa aggtaataag tcagtccatc tgaggaaagc cagttcacca   1380

aatcttcata gacgacagtg ggagaaaaat gtacccaata cagctcttac agctttggaa   1440

aatgcatcca tactcacctc cagtttaaca gcagaggacg atagaggtgg ttctgtaata   1500

aagtacagca aaaatactac tcgtaagcag tggctcaaag agacccctga cactttgttg   1560

aacatcctta agaatgctga tctcagcttg gcttttcaaa catacacaat atatagacca   1620

ggttcagaag ggttcttgaa aggccccctg tctgaagaaa cagaagcatc ggacagtgtt   1680

gatggaggtc acgattctgt cattttggat ccagagcgac ttgagcctgg gctagatgag   1740

gaggacacgg actttgagga ggaagatgac aaccccgact gggtgtcaga gctgaagaag   1800

cgagctggat ggcaaggcct gtgcgacaga taatgcctga ggaaatgttc ctgagtcacg   1860

ctgaggagag gcttcactca ggagttcatg ctgagatgat catgagttca tgcgacgtat   1920

attttccttt ggaaacagaa tgaagcagag gaaactctta atacttaaaa tcgttcttga   1980

ttagtatcgt gagtttgaaa agtctagaac tcctgtaagt ttttgaactc aagggagaag   2040

gtatagtgga atgagtgtga gcatcgggct ttgcagtccc atagaacaga aatgggatgc   2100

tagcgtgcca ctacctactt gtgtgattgt gggaaattac ttaacctctt caagccccaa   2160

tttcctcaac cataaaatga agataataat gcctacctca gagggatgct gaccacagac   2220

ctttatagca gcccgtatga tattattcac attatgatat gtgtttatta ttatgtgact   2280

ctttttacat ttcctaaagg tttgagaatt aaatatattt aattatgatt ta           2332


<210>  3111
<211>  506
<212>  PRT
<213>  Homosapiens

<400>  3111

Met Asp Asp Tyr Met Val Leu Arg Met Ile Gly Glu Gly Ser Phe Gly 
1               5                   10                  15      


Arg Ala Leu Leu Val Gln His Glu Ser Ser Asn Gln Met Phe Ala Met 
            20                  25                  30          


Lys Glu Ile Arg Leu Pro Lys Ser Phe Ser Asn Thr Gln Asn Ser Arg 
        35                  40                  45              


Lys Glu Ala Val Leu Leu Ala Lys Met Lys His Pro Asn Ile Val Ala 
    50                  55                  60                  


Phe Lys Glu Ser Phe Glu Ala Glu Gly His Leu Tyr Ile Val Met Glu 
65                  70                  75                  80  


Tyr Cys Asp Gly Gly Asp Leu Met Gln Lys Ile Lys Gln Gln Lys Gly 
                85                  90                  95      


Lys Leu Phe Pro Glu Asp Met Ile Leu Asn Trp Phe Thr Gln Met Cys 
            100                 105                 110         


Leu Gly Val Asn His Ile His Lys Lys Arg Val Leu His Arg Asp Ile 
        115                 120                 125             


Lys Ser Lys Asn Ile Phe Leu Thr Gln Asn Gly Lys Val Lys Leu Gly 
    130                 135                 140                 


Asp Phe Gly Ser Ala Arg Leu Leu Ser Asn Pro Met Ala Phe Ala Cys 
145                 150                 155                 160 


Thr Tyr Val Gly Thr Pro Tyr Tyr Val Pro Pro Glu Ile Trp Glu Asn 
                165                 170                 175     


Leu Pro Tyr Asn Asn Lys Ser Asp Ile Trp Ser Leu Gly Cys Ile Leu 
            180                 185                 190         


Tyr Glu Leu Cys Thr Leu Lys His Pro Phe Gln Ala Asn Ser Trp Lys 
        195                 200                 205             


Asn Leu Ile Leu Lys Val Cys Gln Gly Cys Ile Ser Pro Leu Pro Ser 
    210                 215                 220                 


His Tyr Ser Tyr Glu Leu Gln Phe Leu Val Lys Gln Met Phe Lys Arg 
225                 230                 235                 240 


Asn Pro Ser His Arg Pro Ser Ala Thr Thr Leu Leu Ser Arg Gly Ile 
                245                 250                 255     


Val Ala Arg Leu Val Gln Lys Cys Leu Pro Pro Glu Ile Ile Met Glu 
            260                 265                 270         


Tyr Gly Glu Glu Val Leu Glu Glu Ile Lys Asn Ser Lys His Asn Thr 
        275                 280                 285             


Pro Arg Lys Lys Thr Asn Pro Ser Arg Ile Arg Ile Ala Leu Gly Asn 
    290                 295                 300                 


Glu Ala Ser Thr Val Gln Glu Glu Glu Gln Asp Arg Lys Gly Ser His 
305                 310                 315                 320 


Thr Asp Leu Glu Ser Ile Asn Glu Asn Leu Val Glu Ser Ala Leu Arg 
                325                 330                 335     


Arg Val Asn Arg Glu Glu Lys Gly Asn Lys Ser Val His Leu Arg Lys 
            340                 345                 350         


Ala Ser Ser Pro Asn Leu His Arg Arg Gln Trp Glu Lys Asn Val Pro 
        355                 360                 365             


Asn Thr Ala Leu Thr Ala Leu Glu Asn Ala Ser Ile Leu Thr Ser Ser 
    370                 375                 380                 


Leu Thr Ala Glu Asp Asp Arg Gly Gly Ser Val Ile Lys Tyr Ser Lys 
385                 390                 395                 400 


Asn Thr Thr Arg Lys Gln Trp Leu Lys Glu Thr Pro Asp Thr Leu Leu 
                405                 410                 415     


Asn Ile Leu Lys Asn Ala Asp Leu Ser Leu Ala Phe Gln Thr Tyr Thr 
            420                 425                 430         


Ile Tyr Arg Pro Gly Ser Glu Gly Phe Leu Lys Gly Pro Leu Ser Glu 
        435                 440                 445             


Glu Thr Glu Ala Ser Asp Ser Val Asp Gly Gly His Asp Ser Val Ile 
    450                 455                 460                 


Leu Asp Pro Glu Arg Leu Glu Pro Gly Leu Asp Glu Glu Asp Thr Asp 
465                 470                 475                 480 


Phe Glu Glu Glu Asp Asp Asn Pro Asp Trp Val Ser Glu Leu Lys Lys 
                485                 490                 495     


Arg Ala Gly Trp Gln Gly Leu Cys Asp Arg 
            500                 505     


<210>  3112
<211>  2255
<212>  DNA
<213>  Homosapiens

<400>  3112
cgccgccttg gggtctgggc gcgcggtgcc gtgggggtca gcagggcgga gcggcttttc     60

caggagaaag ggccctcacg ggtgagcggg gcgactgggc tcccccgcgg tgcagttgcc    120

ccgcgggcgc cggccccggc tcaacggatt cttctcgctc gctgcccgga aagaaccatt    180

tgggagagcc catggtgact gcgtgagtgg agcccagctg tgtggatgcc ccagcatgga    240

tgactacatg gtcctgagaa tgattgggga gggctccttc ggcagagctc ttttggttca    300

gcatgaaagc agtaatcaga tgtttgccat gaaagaaata aggcttccca agtctttctc    360

taatacacag aattctagga aggaggctgt tcttttagcc aaaatgaaac accctaatat    420

tgttgccttc aaagaatcat ttgaagctga aggacacttg tatattgtga tggaatactg    480

tgatggaggg gatctaatgc aaaagattaa acagcagaaa ggaaagttat ttcctgaaga    540

catgatactt aattggttta cccaaatgtg ccttggagta aatcacattc acaagaaacg    600

tgtgctacac agagatatca agtccaagaa tatcttcctc actcagaatg gaaaagtgaa    660

attgggagac tttggatctg cccgtcttct ctccaatccg atggcatttg cttgtaccta    720

tgtgggaact ccttattatg tgcctccaga aatttgggaa aacctgcctt ataacaataa    780

aagtgacatc tggtccttgg gttgcatcct gtatgaactc tgtaccctta agcatccatt    840

tcaggcaaat agttggaaaa atcttatcct caaagtatgt caagggtgca tcagtccact    900

gccgtctcat tactcctatg aacttcagtt cctagtcaag cagatgttta aaaggaatcc    960

ctcacatcgc ccctcggcta caacgcttct ctctcgaggc atcgtagctc ggcttgtcca   1020

gaagtgctta ccccccgaga tcatcatgga atatggtgag gaagtattag aagaaataaa   1080

aaattcgaag cataacacac caagaaaaaa aacaaacccc agcagaatca ggatagcttt   1140

gggaaatgaa gcaagcacag tgcaagagga agaacaagat agaaagggta gccatactga   1200

tttggaaagc attaatgaaa atttagttga aagtgcattg agaagagtaa acagagaaga   1260

aaaaggtaat aagtcagtcc atctgaggaa agccagttca ccaaatcttc atagacgaca   1320

gtgggagaaa aatgtaccca atacagctct tacagctttg gaaaatgcat ccatactcac   1380

ctccagttta acagcagagg acgatagagg tggttctgta ataaagtaca gcaaaaatac   1440

tactcgtaag cagtggctca aagagacccc tgacactttg ttgaacatcc ttaagaatgc   1500

tgatctcagc ttggcttttc aaacatacac aatatataga ccaggttcag aagggttctt   1560

gaaaggcccc ctgtctgaag aaacagaagc atcggacagt gttgatggag gtcacgattc   1620

tgtcattttg gatccagagc gacttgagcc tgggctagat gaggaggaca cggactttga   1680

ggaggaagat gacaaccccg actgggtgtc agagctgaag aagcgagctg gatggcaagg   1740

cctgtgcgac agataatgcc tgaggaaatg ttcctgagtc acgctgagga gaggcttcac   1800

tcaggagttc atgctgagat gatcatgagt tcatgcgacg tatattttcc tttggaaaca   1860

gaatgaagca gaggaaactc ttaatactta aaatcgttct tgattagtat cgtgagtttg   1920

aaaagtctag aactcctgta agtttttgaa ctcaagggag aaggtatagt ggaatgagtg   1980

tgagcatcgg gctttgcagt cccatagaac agaaatggga tgctagcgtg ccactaccta   2040

cttgtgtgat tgtgggaaat tacttaacct cttcaagccc caatttcctc aaccataaaa   2100

tgaagataat aatgcctacc tcagagggat gctgaccaca gacctttata gcagcccgta   2160

tgatattatt cacattatga tatgtgttta ttattatgtg actcttttta catttcctaa   2220

aggtttgaga attaaatata tttaattatg attta                              2255


<210>  3113
<211>  506
<212>  PRT
<213>  Homosapiens

<400>  3113

Met Asp Asp Tyr Met Val Leu Arg Met Ile Gly Glu Gly Ser Phe Gly 
1               5                   10                  15      


Arg Ala Leu Leu Val Gln His Glu Ser Ser Asn Gln Met Phe Ala Met 
            20                  25                  30          


Lys Glu Ile Arg Leu Pro Lys Ser Phe Ser Asn Thr Gln Asn Ser Arg 
        35                  40                  45              


Lys Glu Ala Val Leu Leu Ala Lys Met Lys His Pro Asn Ile Val Ala 
    50                  55                  60                  


Phe Lys Glu Ser Phe Glu Ala Glu Gly His Leu Tyr Ile Val Met Glu 
65                  70                  75                  80  


Tyr Cys Asp Gly Gly Asp Leu Met Gln Lys Ile Lys Gln Gln Lys Gly 
                85                  90                  95      


Lys Leu Phe Pro Glu Asp Met Ile Leu Asn Trp Phe Thr Gln Met Cys 
            100                 105                 110         


Leu Gly Val Asn His Ile His Lys Lys Arg Val Leu His Arg Asp Ile 
        115                 120                 125             


Lys Ser Lys Asn Ile Phe Leu Thr Gln Asn Gly Lys Val Lys Leu Gly 
    130                 135                 140                 


Asp Phe Gly Ser Ala Arg Leu Leu Ser Asn Pro Met Ala Phe Ala Cys 
145                 150                 155                 160 


Thr Tyr Val Gly Thr Pro Tyr Tyr Val Pro Pro Glu Ile Trp Glu Asn 
                165                 170                 175     


Leu Pro Tyr Asn Asn Lys Ser Asp Ile Trp Ser Leu Gly Cys Ile Leu 
            180                 185                 190         


Tyr Glu Leu Cys Thr Leu Lys His Pro Phe Gln Ala Asn Ser Trp Lys 
        195                 200                 205             


Asn Leu Ile Leu Lys Val Cys Gln Gly Cys Ile Ser Pro Leu Pro Ser 
    210                 215                 220                 


His Tyr Ser Tyr Glu Leu Gln Phe Leu Val Lys Gln Met Phe Lys Arg 
225                 230                 235                 240 


Asn Pro Ser His Arg Pro Ser Ala Thr Thr Leu Leu Ser Arg Gly Ile 
                245                 250                 255     


Val Ala Arg Leu Val Gln Lys Cys Leu Pro Pro Glu Ile Ile Met Glu 
            260                 265                 270         


Tyr Gly Glu Glu Val Leu Glu Glu Ile Lys Asn Ser Lys His Asn Thr 
        275                 280                 285             


Pro Arg Lys Lys Thr Asn Pro Ser Arg Ile Arg Ile Ala Leu Gly Asn 
    290                 295                 300                 


Glu Ala Ser Thr Val Gln Glu Glu Glu Gln Asp Arg Lys Gly Ser His 
305                 310                 315                 320 


Thr Asp Leu Glu Ser Ile Asn Glu Asn Leu Val Glu Ser Ala Leu Arg 
                325                 330                 335     


Arg Val Asn Arg Glu Glu Lys Gly Asn Lys Ser Val His Leu Arg Lys 
            340                 345                 350         


Ala Ser Ser Pro Asn Leu His Arg Arg Gln Trp Glu Lys Asn Val Pro 
        355                 360                 365             


Asn Thr Ala Leu Thr Ala Leu Glu Asn Ala Ser Ile Leu Thr Ser Ser 
    370                 375                 380                 


Leu Thr Ala Glu Asp Asp Arg Gly Gly Ser Val Ile Lys Tyr Ser Lys 
385                 390                 395                 400 


Asn Thr Thr Arg Lys Gln Trp Leu Lys Glu Thr Pro Asp Thr Leu Leu 
                405                 410                 415     


Asn Ile Leu Lys Asn Ala Asp Leu Ser Leu Ala Phe Gln Thr Tyr Thr 
            420                 425                 430         


Ile Tyr Arg Pro Gly Ser Glu Gly Phe Leu Lys Gly Pro Leu Ser Glu 
        435                 440                 445             


Glu Thr Glu Ala Ser Asp Ser Val Asp Gly Gly His Asp Ser Val Ile 
    450                 455                 460                 


Leu Asp Pro Glu Arg Leu Glu Pro Gly Leu Asp Glu Glu Asp Thr Asp 
465                 470                 475                 480 


Phe Glu Glu Glu Asp Asp Asn Pro Asp Trp Val Ser Glu Leu Lys Lys 
                485                 490                 495     


Arg Ala Gly Trp Gln Gly Leu Cys Asp Arg 
            500                 505     


<210>  3114
<211>  3054
<212>  DNA
<213>  Homosapiens

<400>  3114
gccccgcggg gctgtgggag ccgaacgccg cggggtcagg gcgtgcagtc tgggacgcgg     60

gatgcttggc gctctacctc gccgcccctg agccttcccg tccgcctcgc cacgcgcccg    120

gacggcctgg ggttgctgcc cgtcagtctc gaaaggtgtt tttggggaaa aaaatcacaa    180

tctggacgtg agaaaggaca tgaggagact aaagacctgg gattttgtca atcagaatga    240

aaccaatgtt gaaagacttt tcaaatctat tgttggtggt actctgtgac tatgttcttg    300

gagaagctga atatcttctc ttgagagagc caggccatgt agcactaagc aacgacacag    360

tgtatgtgga tttccagtat tttgatggtg ctaatgggac actgaggaat gtatctgtcc    420

tgctgttgga ggccaacacc aatcagactg taactaccaa gtacctcctg accaaccagt    480

cccagggaac actaaagttt gagtgcttct atttcaagga ggctggtgac tactggttca    540

caatgactcc agaagcaaca gacaacagca ctccattccc ctggtgggag aaaagtgcct    600

ttctgaaggt ggaatggcct gtctttcacg ttgacttgaa taggagtgcc aaggcagcag    660

aaggcacctt ccaagtgggc ctatttacca gtcaaccact gtgcccgttt cctgtggaca    720

agcccaacat cgtagtggat gtcatcttca ccaacagtct tcctgaggca agaagaaatt    780

caagacagcc gctggaaata agaaccagca aaaggacaga acttgctcaa ggtcagtggg    840

ttgagtttgg ctgtgcaccc ttggggccag aagcctatgt caccgtggtg ctgaagctgc    900

ttgggcgaga ctcagtcatt acctccacag gacccattga cctggcccag aaatttggat    960

acaaactggt gatggtgcca gaactcacat gtgagtccgg ggtagaggtg acagtgctgc   1020

ctccaccatg caccttcgtc caaggagtgg tcactgtctt caaggaggcc cccagatacc   1080

ctgggaagag gaccattcac ttggctgaaa acagcctgcc cctgggagag aggaggacaa   1140

tttttaactg tactttgttt gacatgggga agaataagta ctgctttgac tttggcattt   1200

caagcagaag ccatttttct gcaaaggagg agtgcatgct aattcagaga aatacagaaa   1260

cttggggact gtggcagcca tggagccagt gtagtgccac atgtggggat ggtgtcagag   1320

agcgtcgccg agtgtgtctc acttccttcc cctccagtcc tgtctgccct ggaatgtcct   1380

tggaggcctc cctgtgttcc ctggaggagt gtgctgcttt ccagccatcc agcccatctc   1440

ctcttcagcc ccagggtcca gtgaagtcca acaacatcgt gactgtcact ggtatatcct   1500

tgtgcttgtt catcatcatt gccactgtgc tcatcacgct gtggaggagg ttcggccggc   1560

cagccaagtg cagcacacct gctcgacaca actccatcca ctcccccagc ttccggaaga   1620

actcggacga ggagaatatc tgcgagctga gcgagcagcg cgggagcttc tcggatgggg   1680

gagacgggcc cacggggagt ccaggggaca caggcatccc tctgacctac aggcggagcg   1740

ggccggtacc tcccgaggat gatgcctctg gcagcgagag cttccagtcc aacgcccaga   1800

agataatccc acctctgttc agctaccgcc ttgcccagca gcagttaaag gagatgaaaa   1860

agaaaggtct gacggaaact accaaagtgt atcacgtgtc tcagagtccc ctgacagaca   1920

ctgccattga tgcggccccc agcgctccct tagatttgga aagcccggaa gaagctgcag   1980

caaacaagtt ccggatcaaa tccccatttc cggagcagcc cgcggtcagt gccggggaaa   2040

ggcctccctc caggctggat ctaaatgtga ctcaggccag ttgtgccata agccccagcc   2100

agactctgat ccgcaagtca caggcaaggc acgtgggcag cagagggggc ccgtccgaaa   2160

ggagccatgc caggaacgcc catttcagga ggacagcgag tttccatgaa gccaggcagg   2220

cccggccgtt ccgagagagg agcatgtcca ctctgactcc acggcaggcc cctgcctaca   2280

gctctaggac gcggacctgc gagcaggcag aggacagatt taggcctcag agtcgaggtg   2340

cccacctgtt tcctgaaaaa ctggagcatt tccaagaggc aagtggaacc cgtggtccat   2400

taaaccctct ccctaaatcc tacactttgg ggcagccctt gaggaaacca gaccttgggg   2460

atcaccaggc aggattagtg gccggaattg agagaacaga gccccacaga gctcgtcggg   2520

gaccgtcccc cagtcacaag agtgtctcaa ggaagcagtc ttctcccata tcccccaaag   2580

ataactacca gagggtcagt tctctgagcc cttctcagtg tagaaaagac aagtgtcaaa   2640

gcttccccac tcaccctgag tttgccttct atgacaatac gtcgtttggc ctcactgagg   2700

ctgagcagag gatgctggac ctcccaggat attttgggtc aaatgaagag gatgaaacca   2760

caagtacact tagcgtggag aagctggtga tctagactga gaatcagcct gagctttaca   2820

cagctggggt ctgctactcg cgttttgtag acttttgtgt aactatttgt accgtaggac   2880

agaatgtgag gaggaagtaa cacacagagg aggatgtgtg tgtatgcatg tgtttgaatt   2940

cacaaggaag aaattattta tcttgagctt tttcctttgt tattcaattt ctattgattt   3000

attagtaata acaatgataa taaaatgtaa atgagcaaaa aaaaaaaaaa aaaa         3054


<210>  3115
<211>  852
<212>  PRT
<213>  Homosapiens

<400>  3115

Met Lys Pro Met Leu Lys Asp Phe Ser Asn Leu Leu Leu Val Val Leu 
1               5                   10                  15      


Cys Asp Tyr Val Leu Gly Glu Ala Glu Tyr Leu Leu Leu Arg Glu Pro 
            20                  25                  30          


Gly His Val Ala Leu Ser Asn Asp Thr Val Tyr Val Asp Phe Gln Tyr 
        35                  40                  45              


Phe Asp Gly Ala Asn Gly Thr Leu Arg Asn Val Ser Val Leu Leu Leu 
    50                  55                  60                  


Glu Ala Asn Thr Asn Gln Thr Val Thr Thr Lys Tyr Leu Leu Thr Asn 
65                  70                  75                  80  


Gln Ser Gln Gly Thr Leu Lys Phe Glu Cys Phe Tyr Phe Lys Glu Ala 
                85                  90                  95      


Gly Asp Tyr Trp Phe Thr Met Thr Pro Glu Ala Thr Asp Asn Ser Thr 
            100                 105                 110         


Pro Phe Pro Trp Trp Glu Lys Ser Ala Phe Leu Lys Val Glu Trp Pro 
        115                 120                 125             


Val Phe His Val Asp Leu Asn Arg Ser Ala Lys Ala Ala Glu Gly Thr 
    130                 135                 140                 


Phe Gln Val Gly Leu Phe Thr Ser Gln Pro Leu Cys Pro Phe Pro Val 
145                 150                 155                 160 


Asp Lys Pro Asn Ile Val Val Asp Val Ile Phe Thr Asn Ser Leu Pro 
                165                 170                 175     


Glu Ala Arg Arg Asn Ser Arg Gln Pro Leu Glu Ile Arg Thr Ser Lys 
            180                 185                 190         


Arg Thr Glu Leu Ala Gln Gly Gln Trp Val Glu Phe Gly Cys Ala Pro 
        195                 200                 205             


Leu Gly Pro Glu Ala Tyr Val Thr Val Val Leu Lys Leu Leu Gly Arg 
    210                 215                 220                 


Asp Ser Val Ile Thr Ser Thr Gly Pro Ile Asp Leu Ala Gln Lys Phe 
225                 230                 235                 240 


Gly Tyr Lys Leu Val Met Val Pro Glu Leu Thr Cys Glu Ser Gly Val 
                245                 250                 255     


Glu Val Thr Val Leu Pro Pro Pro Cys Thr Phe Val Gln Gly Val Val 
            260                 265                 270         


Thr Val Phe Lys Glu Ala Pro Arg Tyr Pro Gly Lys Arg Thr Ile His 
        275                 280                 285             


Leu Ala Glu Asn Ser Leu Pro Leu Gly Glu Arg Arg Thr Ile Phe Asn 
    290                 295                 300                 


Cys Thr Leu Phe Asp Met Gly Lys Asn Lys Tyr Cys Phe Asp Phe Gly 
305                 310                 315                 320 


Ile Ser Ser Arg Ser His Phe Ser Ala Lys Glu Glu Cys Met Leu Ile 
                325                 330                 335     


Gln Arg Asn Thr Glu Thr Trp Gly Leu Trp Gln Pro Trp Ser Gln Cys 
            340                 345                 350         


Ser Ala Thr Cys Gly Asp Gly Val Arg Glu Arg Arg Arg Val Cys Leu 
        355                 360                 365             


Thr Ser Phe Pro Ser Ser Pro Val Cys Pro Gly Met Ser Leu Glu Ala 
    370                 375                 380                 


Ser Leu Cys Ser Leu Glu Glu Cys Ala Ala Phe Gln Pro Ser Ser Pro 
385                 390                 395                 400 


Ser Pro Leu Gln Pro Gln Gly Pro Val Lys Ser Asn Asn Ile Val Thr 
                405                 410                 415     


Val Thr Gly Ile Ser Leu Cys Leu Phe Ile Ile Ile Ala Thr Val Leu 
            420                 425                 430         


Ile Thr Leu Trp Arg Arg Phe Gly Arg Pro Ala Lys Cys Ser Thr Pro 
        435                 440                 445             


Ala Arg His Asn Ser Ile His Ser Pro Ser Phe Arg Lys Asn Ser Asp 
    450                 455                 460                 


Glu Glu Asn Ile Cys Glu Leu Ser Glu Gln Arg Gly Ser Phe Ser Asp 
465                 470                 475                 480 


Gly Gly Asp Gly Pro Thr Gly Ser Pro Gly Asp Thr Gly Ile Pro Leu 
                485                 490                 495     


Thr Tyr Arg Arg Ser Gly Pro Val Pro Pro Glu Asp Asp Ala Ser Gly 
            500                 505                 510         


Ser Glu Ser Phe Gln Ser Asn Ala Gln Lys Ile Ile Pro Pro Leu Phe 
        515                 520                 525             


Ser Tyr Arg Leu Ala Gln Gln Gln Leu Lys Glu Met Lys Lys Lys Gly 
    530                 535                 540                 


Leu Thr Glu Thr Thr Lys Val Tyr His Val Ser Gln Ser Pro Leu Thr 
545                 550                 555                 560 


Asp Thr Ala Ile Asp Ala Ala Pro Ser Ala Pro Leu Asp Leu Glu Ser 
                565                 570                 575     


Pro Glu Glu Ala Ala Ala Asn Lys Phe Arg Ile Lys Ser Pro Phe Pro 
            580                 585                 590         


Glu Gln Pro Ala Val Ser Ala Gly Glu Arg Pro Pro Ser Arg Leu Asp 
        595                 600                 605             


Leu Asn Val Thr Gln Ala Ser Cys Ala Ile Ser Pro Ser Gln Thr Leu 
    610                 615                 620                 


Ile Arg Lys Ser Gln Ala Arg His Val Gly Ser Arg Gly Gly Pro Ser 
625                 630                 635                 640 


Glu Arg Ser His Ala Arg Asn Ala His Phe Arg Arg Thr Ala Ser Phe 
                645                 650                 655     


His Glu Ala Arg Gln Ala Arg Pro Phe Arg Glu Arg Ser Met Ser Thr 
            660                 665                 670         


Leu Thr Pro Arg Gln Ala Pro Ala Tyr Ser Ser Arg Thr Arg Thr Cys 
        675                 680                 685             


Glu Gln Ala Glu Asp Arg Phe Arg Pro Gln Ser Arg Gly Ala His Leu 
    690                 695                 700                 


Phe Pro Glu Lys Leu Glu His Phe Gln Glu Ala Ser Gly Thr Arg Gly 
705                 710                 715                 720 


Pro Leu Asn Pro Leu Pro Lys Ser Tyr Thr Leu Gly Gln Pro Leu Arg 
                725                 730                 735     


Lys Pro Asp Leu Gly Asp His Gln Ala Gly Leu Val Ala Gly Ile Glu 
            740                 745                 750         


Arg Thr Glu Pro His Arg Ala Arg Arg Gly Pro Ser Pro Ser His Lys 
        755                 760                 765             


Ser Val Ser Arg Lys Gln Ser Ser Pro Ile Ser Pro Lys Asp Asn Tyr 
    770                 775                 780                 


Gln Arg Val Ser Ser Leu Ser Pro Ser Gln Cys Arg Lys Asp Lys Cys 
785                 790                 795                 800 


Gln Ser Phe Pro Thr His Pro Glu Phe Ala Phe Tyr Asp Asn Thr Ser 
                805                 810                 815     


Phe Gly Leu Thr Glu Ala Glu Gln Arg Met Leu Asp Leu Pro Gly Tyr 
            820                 825                 830         


Phe Gly Ser Asn Glu Glu Asp Glu Thr Thr Ser Thr Leu Ser Val Glu 
        835                 840                 845             


Lys Leu Val Ile 
    850         


<210>  3116
<211>  2896
<212>  DNA
<213>  Homosapiens

<400>  3116
gccccgcggg gctgtgggag ccgaacgccg cggggtcagg gcgtgcagtc tgggacgcgg     60

gatgcttggc gctctacctc gccgcccctg agccttcccg tccgcctcgc cacgcgcccg    120

gacggcctgg ggttgctgcc cgtcagtctc gaggtgtttt tggggaaaaa aatcacaatc    180

tggacgtgag aaaggacatg aggagactaa agacctggga ttttgtcaat cagaatgaaa    240

ccaatgttga aagacttttc aaatctattg ttggtggtac tctgtgacta tgttcttgga    300

gaagctgaat atcttctctt gagagagcca ggccatgtag cactaagcaa cgacacagtg    360

tatgtggatt tccagtattt tgatggtgct aatgggacac tgaggaatgt atctgtcctg    420

ctgttggagg ccaacaccaa tcagactgta actaccaagt acctcctgac caaccagtcc    480

cagggaacac taaagtttga gtgcttctat ttcaaggagg ctggtgacta ctggttcaca    540

atgactccag aagcaacaga caacagcact ccattcccct ggtgggagaa aagtgccttt    600

ctgaaggtgg aatggcctgt ctttcacgtt gacttgaata ggagtgccaa ggcagcagaa    660

ggcaccttcc aagtgggcct atttaccagt caaccactgt gcccgtttcc tgtggacaag    720

cccaacatcg tagtggatgt catcttcacc aacagtcttc ctgaggcaag aagaaattca    780

agacagccgc tggaaataag aaccagcaaa aggacagaac ttgctcaagg tcagtgggtt    840

gagtttggct gtgcaccctt ggggccagaa gcctatgtca ccgtggtgct gaagctgctt    900

gggcgagact cagtcattac ctccacagga cccattgacc tggcccagaa atttggatac    960

aaactggtga tggtgccaga actcacatgt gagtccgggg tagaggtgac agtgctgcct   1020

ccaccatgca ccttcgtcca aggagtggtc actgtcttca aggaggcccc cagataccct   1080

gggaagagga ccattcactt ggctgaaaac agcctgcccc tgggagagag gaggacaatt   1140

tttaactgta ctttgtttga catggggaag aataagtact gctttgactt tggcatttca   1200

agcagaagcc atttttctgc aaaggaggag tgcatgctaa ttcagagaaa tacagctttc   1260

cagccatcca gcccatctcc tcttcagccc cagggtccag tgaagtccaa caacatcgtg   1320

actgtcactg gtatatcctt gtgcttgttc atcatcattg ccactgtgct catcacgctg   1380

tggaggaggt tcggccggcc agccaagtgc agcacacctg ctcgacacaa ctccatccac   1440

tcccccagct tccggaagaa ctcggacgag gagaatatct gcgagctgag cgagcagcgc   1500

gggagcttct cggatggggg agacgggccc acggggagtc caggggacac aggcatccct   1560

ctgacctaca ggcggagcgg gccggtacct cccgaggatg atgcctctgg cagcgagagc   1620

ttccagtcca acgcccagaa gataatccca cctctgttca gctaccgcct tgcccagcag   1680

cagttaaagg agatgaaaaa gaaaggtctg acggaaacta ccaaagtgta tcacgtgtct   1740

cagagtcccc tgacagacac tgccattgat gcggccccca gcgctccctt agatttggaa   1800

agcccggaag aagctgcagc aaacaagttc cggatcaaat ccccatttcc ggagcagccc   1860

gcggtcagtg ccggggaaag gcctccctcc aggctggatc taaatgtgac tcaggccagt   1920

tgtgccataa gccccagcca gactctgatc cgcaagtcac aggcaaggca cgtgggcagc   1980

agagggggcc cgtccgaaag gagccatgcc aggaacgccc atttcaggag gacagcgagt   2040

ttccatgaag ccaggcaggc ccggccgttc cgagagagga gcatgtccac tctgactcca   2100

cggcaggccc ctgcctacag ctctaggacg cggacctgcg agcaggcaga ggacagattt   2160

aggcctcaga gtcgaggtgc ccacctgttt cctgaaaaac tggagcattt ccaagaggca   2220

agtggaaccc gtggtccatt aaaccctctc cctaaatcct acactttggg gcagcccttg   2280

aggaaaccag accttgggga tcaccaggca ggattagtgg ccggaattga gagaacagag   2340

ccccacagag ctcgtcgggg accgtccccc agtcacaaga gtgtctcaag gaagcagtct   2400

tctcccatat cccccaaaga taactaccag agggtcagtt ctctgagccc ttctcagtgt   2460

agaaaagaca agtgtcaaag cttccccact caccctgagt ttgccttcta tgacaatacg   2520

tcgtttggcc tcactgaggc tgagcagagg atgctggacc tcccaggata ttttgggtca   2580

aatgaagagg atgaaaccac aagtacactt agcgtggaga agctggtgat ctagactgag   2640

aatcagcctg agctttacac agctggggtc tgctactcgc gttttgtaga cttttgtgta   2700

actatttgta ccgtaggaca gaatgtgagg aggaagtaac acacagagga ggatgtgtgt   2760

gtatgcatgt gtttgaattc acaaggaaga aattatttat cttgagcttt ttcctttgtt   2820

attcaatttc tattgattta ttagtaataa caatgataat aaaatgtaaa tgagcaaaaa   2880

aaaaaaaaaa aaaaaa                                                   2896


<210>  3117
<211>  799
<212>  PRT
<213>  Homosapiens

<400>  3117

Met Lys Pro Met Leu Lys Asp Phe Ser Asn Leu Leu Leu Val Val Leu 
1               5                   10                  15      


Cys Asp Tyr Val Leu Gly Glu Ala Glu Tyr Leu Leu Leu Arg Glu Pro 
            20                  25                  30          


Gly His Val Ala Leu Ser Asn Asp Thr Val Tyr Val Asp Phe Gln Tyr 
        35                  40                  45              


Phe Asp Gly Ala Asn Gly Thr Leu Arg Asn Val Ser Val Leu Leu Leu 
    50                  55                  60                  


Glu Ala Asn Thr Asn Gln Thr Val Thr Thr Lys Tyr Leu Leu Thr Asn 
65                  70                  75                  80  


Gln Ser Gln Gly Thr Leu Lys Phe Glu Cys Phe Tyr Phe Lys Glu Ala 
                85                  90                  95      


Gly Asp Tyr Trp Phe Thr Met Thr Pro Glu Ala Thr Asp Asn Ser Thr 
            100                 105                 110         


Pro Phe Pro Trp Trp Glu Lys Ser Ala Phe Leu Lys Val Glu Trp Pro 
        115                 120                 125             


Val Phe His Val Asp Leu Asn Arg Ser Ala Lys Ala Ala Glu Gly Thr 
    130                 135                 140                 


Phe Gln Val Gly Leu Phe Thr Ser Gln Pro Leu Cys Pro Phe Pro Val 
145                 150                 155                 160 


Asp Lys Pro Asn Ile Val Val Asp Val Ile Phe Thr Asn Ser Leu Pro 
                165                 170                 175     


Glu Ala Arg Arg Asn Ser Arg Gln Pro Leu Glu Ile Arg Thr Ser Lys 
            180                 185                 190         


Arg Thr Glu Leu Ala Gln Gly Gln Trp Val Glu Phe Gly Cys Ala Pro 
        195                 200                 205             


Leu Gly Pro Glu Ala Tyr Val Thr Val Val Leu Lys Leu Leu Gly Arg 
    210                 215                 220                 


Asp Ser Val Ile Thr Ser Thr Gly Pro Ile Asp Leu Ala Gln Lys Phe 
225                 230                 235                 240 


Gly Tyr Lys Leu Val Met Val Pro Glu Leu Thr Cys Glu Ser Gly Val 
                245                 250                 255     


Glu Val Thr Val Leu Pro Pro Pro Cys Thr Phe Val Gln Gly Val Val 
            260                 265                 270         


Thr Val Phe Lys Glu Ala Pro Arg Tyr Pro Gly Lys Arg Thr Ile His 
        275                 280                 285             


Leu Ala Glu Asn Ser Leu Pro Leu Gly Glu Arg Arg Thr Ile Phe Asn 
    290                 295                 300                 


Cys Thr Leu Phe Asp Met Gly Lys Asn Lys Tyr Cys Phe Asp Phe Gly 
305                 310                 315                 320 


Ile Ser Ser Arg Ser His Phe Ser Ala Lys Glu Glu Cys Met Leu Ile 
                325                 330                 335     


Gln Arg Asn Thr Ala Phe Gln Pro Ser Ser Pro Ser Pro Leu Gln Pro 
            340                 345                 350         


Gln Gly Pro Val Lys Ser Asn Asn Ile Val Thr Val Thr Gly Ile Ser 
        355                 360                 365             


Leu Cys Leu Phe Ile Ile Ile Ala Thr Val Leu Ile Thr Leu Trp Arg 
    370                 375                 380                 


Arg Phe Gly Arg Pro Ala Lys Cys Ser Thr Pro Ala Arg His Asn Ser 
385                 390                 395                 400 


Ile His Ser Pro Ser Phe Arg Lys Asn Ser Asp Glu Glu Asn Ile Cys 
                405                 410                 415     


Glu Leu Ser Glu Gln Arg Gly Ser Phe Ser Asp Gly Gly Asp Gly Pro 
            420                 425                 430         


Thr Gly Ser Pro Gly Asp Thr Gly Ile Pro Leu Thr Tyr Arg Arg Ser 
        435                 440                 445             


Gly Pro Val Pro Pro Glu Asp Asp Ala Ser Gly Ser Glu Ser Phe Gln 
    450                 455                 460                 


Ser Asn Ala Gln Lys Ile Ile Pro Pro Leu Phe Ser Tyr Arg Leu Ala 
465                 470                 475                 480 


Gln Gln Gln Leu Lys Glu Met Lys Lys Lys Gly Leu Thr Glu Thr Thr 
                485                 490                 495     


Lys Val Tyr His Val Ser Gln Ser Pro Leu Thr Asp Thr Ala Ile Asp 
            500                 505                 510         


Ala Ala Pro Ser Ala Pro Leu Asp Leu Glu Ser Pro Glu Glu Ala Ala 
        515                 520                 525             


Ala Asn Lys Phe Arg Ile Lys Ser Pro Phe Pro Glu Gln Pro Ala Val 
    530                 535                 540                 


Ser Ala Gly Glu Arg Pro Pro Ser Arg Leu Asp Leu Asn Val Thr Gln 
545                 550                 555                 560 


Ala Ser Cys Ala Ile Ser Pro Ser Gln Thr Leu Ile Arg Lys Ser Gln 
                565                 570                 575     


Ala Arg His Val Gly Ser Arg Gly Gly Pro Ser Glu Arg Ser His Ala 
            580                 585                 590         


Arg Asn Ala His Phe Arg Arg Thr Ala Ser Phe His Glu Ala Arg Gln 
        595                 600                 605             


Ala Arg Pro Phe Arg Glu Arg Ser Met Ser Thr Leu Thr Pro Arg Gln 
    610                 615                 620                 


Ala Pro Ala Tyr Ser Ser Arg Thr Arg Thr Cys Glu Gln Ala Glu Asp 
625                 630                 635                 640 


Arg Phe Arg Pro Gln Ser Arg Gly Ala His Leu Phe Pro Glu Lys Leu 
                645                 650                 655     


Glu His Phe Gln Glu Ala Ser Gly Thr Arg Gly Pro Leu Asn Pro Leu 
            660                 665                 670         


Pro Lys Ser Tyr Thr Leu Gly Gln Pro Leu Arg Lys Pro Asp Leu Gly 
        675                 680                 685             


Asp His Gln Ala Gly Leu Val Ala Gly Ile Glu Arg Thr Glu Pro His 
    690                 695                 700                 


Arg Ala Arg Arg Gly Pro Ser Pro Ser His Lys Ser Val Ser Arg Lys 
705                 710                 715                 720 


Gln Ser Ser Pro Ile Ser Pro Lys Asp Asn Tyr Gln Arg Val Ser Ser 
                725                 730                 735     


Leu Ser Pro Ser Gln Cys Arg Lys Asp Lys Cys Gln Ser Phe Pro Thr 
            740                 745                 750         


His Pro Glu Phe Ala Phe Tyr Asp Asn Thr Ser Phe Gly Leu Thr Glu 
        755                 760                 765             


Ala Glu Gln Arg Met Leu Asp Leu Pro Gly Tyr Phe Gly Ser Asn Glu 
    770                 775                 780                 


Glu Asp Glu Thr Thr Ser Thr Leu Ser Val Glu Lys Leu Val Ile 
785                 790                 795                 


<210>  3118
<211>  4427
<212>  DNA
<213>  Homosapiens

<400>  3118
ggcctcggag ggccggggct gggtggcagc ggccatggac cgcttcgttt ggaccagcgg     60

cctcctggag atcaacgaga ccctggtgat ccagcagcgc ggggtgcgaa tctacgatgg    120

cgaggagaag ataaaatttg atgctgggac tctccttctt agtacacacc gactgatttg    180

gagagatcag aaaaatcatg agtgttgcat ggccattctc ctttcccaaa ttgtgttcat    240

tgaagaacag gcggctggaa ttgggaagag tgccaaaata gtggttcatc ttcacccagc    300

tcctcctaac aaagaacctg gcccattcca gagtagtaag aactcctaca tcaaactctc    360

cttcaaagaa catggccaga ttgagtttta caggcgttta tcagaggaaa tgacacaaag    420

aagatgggag aatatgccag tttcccagtc attacaaaca aatagaggac cccagccagg    480

aagaataagg gctgtaggaa ttgtaggtat tgaaaggaaa ctggaagaaa aaagaaaaga    540

aactgacaaa aacatttctg aggcctttga agacctcagc aaactaatga tcaaggctaa    600

ggaaatggtg gaattatcaa aatcaattgc taataaaatt aaagacaaac aaggtgacat    660

cacagaagat gagaccatca ggtttaaatc ctacttgctg agcatgggaa tagctaaccc    720

agttaccaga gaaacctacg gctcaggcac acagtaccac atgcagctgg ccaaacaact    780

ggctggaata ttgcaggtgc ctttagagga acgaggggga ataatgtcac tcacggaggt    840

gtactgctta gtaaaccgag ctcgaggaat ggaattgctc tcaccagaag atttagtgaa    900

tgcgtgcaag atgctggaag cactgaaatt acctctcagg ctccgtgtgt ttgacagtgg    960

cgtcatggta attgagcttc agtctcacaa ggaagaggaa atggtggcct cggccctgga   1020

gacagtttca gaaaagggat ccctaacatc agaagagttt gctaagcttg tgggaatgtc   1080

tgtcctccta gccaaagaaa ggttgctgct tgcagagaag atgggccatc tttgccgtga   1140

tgactcagtg gaaggcctgc gtttttaccc aaatttattt atgacacaga gctaagggtt   1200

ttgtatttaa aatccttttt gtccatatgc ttgcgtcatg tagaggttgt atgacattga   1260

gctaagagat aaaccccgat caattgagaa tttattggaa cttcacagtg caatgtaaat   1320

ctcttttaat ttctcactaa atatggtcca ggaaatttat ttagtatacg cataggaaaa   1380

ttcagaaaag tgaatgccaa tatgaattta aaatcatgct atagtgcaga accctcagag   1440

tttaacttgg aatatagtgg attttaactt gatcctcaaa tctaatcatt ttataaagaa   1500

gggaatttag ttttgcagag aataaaaaga gaagttgcat gttcagacag gttagattat   1560

tattttggtg taactgaaat tcactgattg cacatgacaa tgttgggaca aaatatactg   1620

cagcatgcta tatgaggctc ctccccaggg cttttagaag cagtcataga catgtcttca   1680

acataccaaa taaaatacct ttaaaaatga aataatttta tttgacacat atatttatat   1740

atattctatc tagtttctct ttgttttttt aagtgatgat ttcatgactg gcatttaaag   1800

aatgcaactg tgtcattttg tttccaaatg ctgtggattt tgaaactgaa ctagagagct   1860

gtatagacat gcccagagtt atgattacaa atttaggagg tagacggctc aggaattccc   1920

tgggattgtt gtgctggtgg aatggcagag ggaacttcac aggaacctta gtgttctttt   1980

acctcaaagc cacagacagg aaatagaaag tggaaaagta atatctcctt ttcttttcca   2040

taaggagttt caacactgaa ctttaaaaag tctatcatat tccagcaata ttttttcttt   2100

gtcctttatg ttgtaagttg tgtggaaaaa ctacttcggt aagaaatgtt actgagataa   2160

caacaactgg ctaatactgc atgtagattg cttaggtttt aaagtgactg cctgacttca   2220

catgttattg ctacagcctc cagtatgttc gcattatctc aaactcaggg accccacagg   2280

acaggagaca ccctttctga aactgagttg gaagtgaaag ggtggtgatg gttttggcca   2340

agcctgcggg agggaaagta ttgtattggg agcacccttg ggaccaggaa gagggatgcc   2400

caggttcaca ctctgggacc cctaagacat tgtcagtggg taaggtggag ggccactgcc   2460

agaggctgct gcagtgccct ctgggaagtg ccagggaccc tcagctgcag acccagggga   2520

tcccaatccc ttatctctgc ctgaaaagtg gctattgctg cttcgtatcc tccagtgtca   2580

caggaatgct gtgcctgaga catcccactt tagtttttgt tttccaaacc tgtcactgac   2640

tcttcattgt ggtgacagat cctctggttc ccccattgct cagcctcagg tttattttga   2700

gggtaactca gtgtctgact gcccaagtct tttaggggtt agttggacca ttgtgtaagc   2760

ttgtttgtat gtctcacctc tttctggttg gtacttactg tctcacactg ctctggcaaa   2820

cttgtacaca cacacacact ctctctctct ctcacctggc taaggctttt aaaattatga   2880

agataaataa tctgtttcac cagctggagt gagttgcaag gaagattgct ggagctactc   2940

aatctagcgc taatggtttg gattcattac tgcaaaccta cataatttaa catatttgtt   3000

tactttagtg tgacaactga tgaaaaaaaa tggagcaatc tgaattgtat aaaataactt   3060

aagaaggaag aaaagtgata tataaatata ttttgcaaat gtcacattaa tttaaaaatg   3120

agtatgattg attttatttt taaagtgggc attcttcact gtttcgagac ctttgtatgt   3180

atttgtgtat ttttatcttt ttttttcagg ccattattat aaggtgttat tttggccctc   3240

taatgtagaa gttatgttta aatacaacca atcaggccct aagtgcaaaa aagttctgtc   3300

ttggtgctta tcactggtat aattattatt tttttgtttt cctaactttg ctcttaggag   3360

catgagcctc tttgtagctt tatggtaatg caatatttct ggtcatttac tgtcaaaaaa   3420

tttttttaca ttgtgttagt gaagactgtg ttttcagggt taaatgattg gtatcaatgt   3480

atatagagta aaattattgc aaaatttaaa aatgattttt cttggcattc tttttaaata   3540

ctctgaaaca tatatgcaaa tgagaaacct ttaatcatac taaagccagt tatgttaaga   3600

atttttcctt tggattttat aattaagagt tgcttataaa tacttatgac attgagctct   3660

tactgtttta gttgtcttaa aacaatggga catgtcatga actggtttct ttttttaaaa   3720

aattcttgat gtgaattcca ctgttacctg accatgtata ttcagatgaa tgtactcttt   3780

cttgttcctt gttaccagat taatctgaga gaatgtggat tcatcctgtc atctttctca   3840

tactcaaata cttaaaatgg ttcttttgcc caaaagtctc agagtcttca ttttggtaca   3900

gtggagtcac aacttgtaag gtggttaggt tttaaagacc gtgcctaagg acaaaattga   3960

gcatgctcag aatggtcctt gaaaatctcc taaattacca ataaatttct ctttgtagtc   4020

ttaaagttta aatccctgtg gagtgatatg taggtatgaa tatattatgc ttatattaag   4080

tacaaaaata caaactgcat atcaagagat tcttatagca ttaataattt ccatgcatgt   4140

gtctttttcc agtaggtatg gttgaattta tgtaaattta ttgctaatcc catcccttac   4200

gatctagagt ataagctgcg caagggcaga agtttttatc tggtttgttc atggatgtat   4260

tctaagagct gagaacaggg cctggacaca ataagcattc aataaatatt tactgaatga   4320

atgaactcct acctatattc ctatttataa tttggctcca ctttatccta ctttagctcc   4380

cattcaattc aataaaaaaa acattttttt gaacacatag caaaaaa                 4427


<210>  3119
<211>  386
<212>  PRT
<213>  Homosapiens

<400>  3119

Met Asp Arg Phe Val Trp Thr Ser Gly Leu Leu Glu Ile Asn Glu Thr 
1               5                   10                  15      


Leu Val Ile Gln Gln Arg Gly Val Arg Ile Tyr Asp Gly Glu Glu Lys 
            20                  25                  30          


Ile Lys Phe Asp Ala Gly Thr Leu Leu Leu Ser Thr His Arg Leu Ile 
        35                  40                  45              


Trp Arg Asp Gln Lys Asn His Glu Cys Cys Met Ala Ile Leu Leu Ser 
    50                  55                  60                  


Gln Ile Val Phe Ile Glu Glu Gln Ala Ala Gly Ile Gly Lys Ser Ala 
65                  70                  75                  80  


Lys Ile Val Val His Leu His Pro Ala Pro Pro Asn Lys Glu Pro Gly 
                85                  90                  95      


Pro Phe Gln Ser Ser Lys Asn Ser Tyr Ile Lys Leu Ser Phe Lys Glu 
            100                 105                 110         


His Gly Gln Ile Glu Phe Tyr Arg Arg Leu Ser Glu Glu Met Thr Gln 
        115                 120                 125             


Arg Arg Trp Glu Asn Met Pro Val Ser Gln Ser Leu Gln Thr Asn Arg 
    130                 135                 140                 


Gly Pro Gln Pro Gly Arg Ile Arg Ala Val Gly Ile Val Gly Ile Glu 
145                 150                 155                 160 


Arg Lys Leu Glu Glu Lys Arg Lys Glu Thr Asp Lys Asn Ile Ser Glu 
                165                 170                 175     


Ala Phe Glu Asp Leu Ser Lys Leu Met Ile Lys Ala Lys Glu Met Val 
            180                 185                 190         


Glu Leu Ser Lys Ser Ile Ala Asn Lys Ile Lys Asp Lys Gln Gly Asp 
        195                 200                 205             


Ile Thr Glu Asp Glu Thr Ile Arg Phe Lys Ser Tyr Leu Leu Ser Met 
    210                 215                 220                 


Gly Ile Ala Asn Pro Val Thr Arg Glu Thr Tyr Gly Ser Gly Thr Gln 
225                 230                 235                 240 


Tyr His Met Gln Leu Ala Lys Gln Leu Ala Gly Ile Leu Gln Val Pro 
                245                 250                 255     


Leu Glu Glu Arg Gly Gly Ile Met Ser Leu Thr Glu Val Tyr Cys Leu 
            260                 265                 270         


Val Asn Arg Ala Arg Gly Met Glu Leu Leu Ser Pro Glu Asp Leu Val 
        275                 280                 285             


Asn Ala Cys Lys Met Leu Glu Ala Leu Lys Leu Pro Leu Arg Leu Arg 
    290                 295                 300                 


Val Phe Asp Ser Gly Val Met Val Ile Glu Leu Gln Ser His Lys Glu 
305                 310                 315                 320 


Glu Glu Met Val Ala Ser Ala Leu Glu Thr Val Ser Glu Lys Gly Ser 
                325                 330                 335     


Leu Thr Ser Glu Glu Phe Ala Lys Leu Val Gly Met Ser Val Leu Leu 
            340                 345                 350         


Ala Lys Glu Arg Leu Leu Leu Ala Glu Lys Met Gly His Leu Cys Arg 
        355                 360                 365             


Asp Asp Ser Val Glu Gly Leu Arg Phe Tyr Pro Asn Leu Phe Met Thr 
    370                 375                 380                 


Gln Ser 
385     


<210>  3120
<211>  3626
<212>  DNA
<213>  Homosapiens

<400>  3120
gacggcttag ccgcggtgca gactgcggcg gcggtggtct gaggaagttc tatcttggcg     60

ctaaagcgga gacgcatccc ccgacccgag gctacgatga gcacaccggc cgtgccccag    120

gacctgcagc tgcccccgag tcagagggcg cagtccgcat tcaaagagca aagaagacaa    180

aaactcaagg aacatctgtt gagaagaaaa acgctttttg catacaagca ggaaaatgag    240

atgttatcca gtagagatca gagagttgtg acatctgagg accaagttca agaagggact    300

aaagtgctga aacttaaaac aaaaatggct gataaagaaa acatgaagag acctgcagag    360

agcaaaaata atacagtggt ggggaaacat tgtattcctt taaaaccttc aaatgaacta    420

accaattcaa ctgtagtaat tgacacacat aaacctaagg atagtaatca aactccgcat    480

ttgttactaa ctgaagatga tccccaaagt caacatatga cattaagcca ggcatttcac    540

cttaaaaaca atagtaaaaa gaaacaaatg actacagaaa aacaaaagca agatgctaac    600

atgcccaaga aacctgtgct tggatcttat cgtggccaga ttgttcagtc taagattaat    660

tcatttagaa aacctctaca agtcaaagat gagagttctg cagcaacaaa gaaactttca    720

gccactatac ctaaagccac aaaacctcag cctgtaaaca ccagcagtgt aacagtgaaa    780

agtaatagat cctccaatat gactgccact actaaatttg tgagcactac atctcagaac    840

acacaacttg tgcgacctcc tattagaagt catcacagta atacccggga cactgtgaaa    900

caaggcatca gtagaacctc tgccaatgtt acaatccgga aagggcctca tgaaaaagaa    960

ctattacaat caaaaacagc tttatctagt gtcaaaacca gttcttctca aggtataata   1020

agaaataaga ctctatcaag atccatagca tctgaagttg tagccaggcc tgcttcattg   1080

tctaatgata aactgatgga aaagtcagag cccgttgacc agcgaagaca tactgcagga   1140

aaagcaattg ttgatagtag atcagctcag cccaaagaaa cctcggaaga gagaaaagct   1200

cgtctgagtg agtggaaagc tggcaaagga agagtgctaa aaaggccccc taattcagta   1260

gttactcagc atgagcctgc aggacaaaat gaaaaaccag ttgggtcttt ttggactacc   1320

atggcagaag aagatgaaca aagattattt actgaaaaag taaacaacac attttctgaa   1380

tgcctgaact tgattaatga gggatgtcca aaagaagata tactggtcac actgaatgac   1440

ctgattaaaa atattccaga tgccaaaaag cttgttaagt attggatatg tcttgcactt   1500

attgaaccaa tcacaagtcc tattgaaaat attattgcaa tctatgagaa agccattctg   1560

gcaggggctc agcctattga agagatgcga cacacgattg tagatattct aacaatgaag   1620

agtcaagaaa aagctaattt aggagaaaat atggagaagt cttgtgcaag caaggaagaa   1680

gtcagagaag tcagtattga agatacaggt gttgatgtag atccagaaaa actggaaatg   1740

gagagtaaac ttcatagaaa tttgctactt caagattgtg aaaaagagca agacaacaaa   1800

acaaaagatc caacccatga tgctaaaacc cccaatacag aaacgaggac aagttgctta   1860

attaaatata atgtgtctac tacgccatac ttgcaaagtg tgaaaaaaaa ggtgcagttt   1920

gatggaacaa attccgcatt taaagagctg aagtttttaa caccagtgag acgttctcga   1980

cgtcttcaag agaaaacttc taaattgcca gatatgttaa aagatcatta tccttgtgtg   2040

tcttcattgg aacagctaac ggagttggga agagaaactg atgcttttgt atgccgccct   2100

aatgcagcac tgtgccgggt gtactatgag gctgatacaa cataagggaa ataaagctct   2160

gttagggaat ggggttttta ttatttgtgg ggtgttttgt tttgagtagc tttatattgc   2220

tcttaggtct ggagttggcc atgtacctat gtatcctaag cattcacggc agtgagctcc   2280

tttactaaca ttcatgttat ggcaagagtt gtcctctaca ttggaaagct aatcctacct   2340

tgtcagtttc aaccaactga gttttttctt taagaaaggt aaattttgtc agctagttta   2400

ctatgttcct tgaatataaa caggttataa tactaccctg ttcactttac taaatataag   2460

tacagtaatg atgcataatt agaaaatgag gtattctagg taaaatgtat gtttgccttg   2520

acatgttttt aaaagttatg atgtacctcc ctgcctttaa acagaatact tttttctttt   2580

ttttggcctt tctcagatta gtcaaaaatt ctatagaatg actcacttcg aatactaaga   2640

cacaggaggt ttagcctgct ttcttaccaa attcatgtta cccagacttg tgttctcttg   2700

cgtcccttgg actgcctgtt gattgatgga aagtgtctgc actgacactt ttcgtcagta   2760

gtctgtagtt tcgtggcctc ttttgattat aactggggtc accaagaagg tttacttaat   2820

taaataccgc atttctaaga gaagatactt tgtgtaagaa aagatgccac atttagtggt   2880

ttaacttttg taacttcact tgatagtttt taagcaatta gaatggagtt agggaaagaa   2940

catatcatac tgaacaaatg tcattctagt ttagatagca tttctaagat aactgatact   3000

aatacttgtt ttcttcccta taacataaaa aacttcactg ttaagtcatg tcccttgaaa   3060

catgatagtt acatacacag ttttctctcc acacataaat aacaccacta aagttgtttt   3120

gtaaggttcc aaactaatat ggcatatatc aactctacag tttcaaataa atgacttttt   3180

aattgtaaaa gattagttga aaaactgtat gaatgtgaag atcacatgct tagtcatttc   3240

tatgttcatt ccactttgta tatcttttct atttattgac ttctcatgtt ctagagagta   3300

ggacttttat tccgtgtacc tgatatatat acaattaaaa tatctgtata attatgtttt   3360

aatgaggttt atttcaacag atattttatg aaatgcagtt taaccacagt gaatgaattt   3420

tagctttgct tttgaaatac attgtaagat ttgacttgag gtttttgaca cttaagtaca   3480

tgcttaatga tatattttca aaagtcatca gtctacttac ataaacttta cctaattttt   3540

ttcactttaa caaaaacata actatgccct tgttttttca tactttgacc caaaatatgc   3600

cattttgaaa taaaatttaa gctttg                                        3626


<210>  3121
<211>  682
<212>  PRT
<213>  Homosapiens

<400>  3121

Met Ser Thr Pro Ala Val Pro Gln Asp Leu Gln Leu Pro Pro Ser Gln 
1               5                   10                  15      


Arg Ala Gln Ser Ala Phe Lys Glu Gln Arg Arg Gln Lys Leu Lys Glu 
            20                  25                  30          


His Leu Leu Arg Arg Lys Thr Leu Phe Ala Tyr Lys Gln Glu Asn Glu 
        35                  40                  45              


Met Leu Ser Ser Arg Asp Gln Arg Val Val Thr Ser Glu Asp Gln Val 
    50                  55                  60                  


Gln Glu Gly Thr Lys Val Leu Lys Leu Lys Thr Lys Met Ala Asp Lys 
65                  70                  75                  80  


Glu Asn Met Lys Arg Pro Ala Glu Ser Lys Asn Asn Thr Val Val Gly 
                85                  90                  95      


Lys His Cys Ile Pro Leu Lys Pro Ser Asn Glu Leu Thr Asn Ser Thr 
            100                 105                 110         


Val Val Ile Asp Thr His Lys Pro Lys Asp Ser Asn Gln Thr Pro His 
        115                 120                 125             


Leu Leu Leu Thr Glu Asp Asp Pro Gln Ser Gln His Met Thr Leu Ser 
    130                 135                 140                 


Gln Ala Phe His Leu Lys Asn Asn Ser Lys Lys Lys Gln Met Thr Thr 
145                 150                 155                 160 


Glu Lys Gln Lys Gln Asp Ala Asn Met Pro Lys Lys Pro Val Leu Gly 
                165                 170                 175     


Ser Tyr Arg Gly Gln Ile Val Gln Ser Lys Ile Asn Ser Phe Arg Lys 
            180                 185                 190         


Pro Leu Gln Val Lys Asp Glu Ser Ser Ala Ala Thr Lys Lys Leu Ser 
        195                 200                 205             


Ala Thr Ile Pro Lys Ala Thr Lys Pro Gln Pro Val Asn Thr Ser Ser 
    210                 215                 220                 


Val Thr Val Lys Ser Asn Arg Ser Ser Asn Met Thr Ala Thr Thr Lys 
225                 230                 235                 240 


Phe Val Ser Thr Thr Ser Gln Asn Thr Gln Leu Val Arg Pro Pro Ile 
                245                 250                 255     


Arg Ser His His Ser Asn Thr Arg Asp Thr Val Lys Gln Gly Ile Ser 
            260                 265                 270         


Arg Thr Ser Ala Asn Val Thr Ile Arg Lys Gly Pro His Glu Lys Glu 
        275                 280                 285             


Leu Leu Gln Ser Lys Thr Ala Leu Ser Ser Val Lys Thr Ser Ser Ser 
    290                 295                 300                 


Gln Gly Ile Ile Arg Asn Lys Thr Leu Ser Arg Ser Ile Ala Ser Glu 
305                 310                 315                 320 


Val Val Ala Arg Pro Ala Ser Leu Ser Asn Asp Lys Leu Met Glu Lys 
                325                 330                 335     


Ser Glu Pro Val Asp Gln Arg Arg His Thr Ala Gly Lys Ala Ile Val 
            340                 345                 350         


Asp Ser Arg Ser Ala Gln Pro Lys Glu Thr Ser Glu Glu Arg Lys Ala 
        355                 360                 365             


Arg Leu Ser Glu Trp Lys Ala Gly Lys Gly Arg Val Leu Lys Arg Pro 
    370                 375                 380                 


Pro Asn Ser Val Val Thr Gln His Glu Pro Ala Gly Gln Asn Glu Lys 
385                 390                 395                 400 


Pro Val Gly Ser Phe Trp Thr Thr Met Ala Glu Glu Asp Glu Gln Arg 
                405                 410                 415     


Leu Phe Thr Glu Lys Val Asn Asn Thr Phe Ser Glu Cys Leu Asn Leu 
            420                 425                 430         


Ile Asn Glu Gly Cys Pro Lys Glu Asp Ile Leu Val Thr Leu Asn Asp 
        435                 440                 445             


Leu Ile Lys Asn Ile Pro Asp Ala Lys Lys Leu Val Lys Tyr Trp Ile 
    450                 455                 460                 


Cys Leu Ala Leu Ile Glu Pro Ile Thr Ser Pro Ile Glu Asn Ile Ile 
465                 470                 475                 480 


Ala Ile Tyr Glu Lys Ala Ile Leu Ala Gly Ala Gln Pro Ile Glu Glu 
                485                 490                 495     


Met Arg His Thr Ile Val Asp Ile Leu Thr Met Lys Ser Gln Glu Lys 
            500                 505                 510         


Ala Asn Leu Gly Glu Asn Met Glu Lys Ser Cys Ala Ser Lys Glu Glu 
        515                 520                 525             


Val Arg Glu Val Ser Ile Glu Asp Thr Gly Val Asp Val Asp Pro Glu 
    530                 535                 540                 


Lys Leu Glu Met Glu Ser Lys Leu His Arg Asn Leu Leu Leu Gln Asp 
545                 550                 555                 560 


Cys Glu Lys Glu Gln Asp Asn Lys Thr Lys Asp Pro Thr His Asp Ala 
                565                 570                 575     


Lys Thr Pro Asn Thr Glu Thr Arg Thr Ser Cys Leu Ile Lys Tyr Asn 
            580                 585                 590         


Val Ser Thr Thr Pro Tyr Leu Gln Ser Val Lys Lys Lys Val Gln Phe 
        595                 600                 605             


Asp Gly Thr Asn Ser Ala Phe Lys Glu Leu Lys Phe Leu Thr Pro Val 
    610                 615                 620                 


Arg Arg Ser Arg Arg Leu Gln Glu Lys Thr Ser Lys Leu Pro Asp Met 
625                 630                 635                 640 


Leu Lys Asp His Tyr Pro Cys Val Ser Ser Leu Glu Gln Leu Thr Glu 
                645                 650                 655     


Leu Gly Arg Glu Thr Asp Ala Phe Val Cys Arg Pro Asn Ala Ala Leu 
            660                 665                 670         


Cys Arg Val Tyr Tyr Glu Ala Asp Thr Thr 
        675                 680         


<210>  3122
<211>  2627
<212>  DNA
<213>  Homosapiens

<400>  3122
gacgggagct ctgctcaggc ttcaacatgg cgggccgttt cggttgactt cgcctgtgga     60

aaccgaattc cccctccatg gtttccccag gatatgagtt gggggcctca cctcgcctat    120

aagggtcagg cgagctttct ggatgctcga gggacctttc ggcctgcgca gccggagcag    180

cttgtcccaa tgccctgcca tttctgtgag ggcccacgag gcctggagga gcctcggagc    240

ccccgcaggc cctcgcgtca ctgcctcaag agggtgctcg gagccctgct cgggagctgg    300

tccccaacga ggtgtggaac cccttcttgc tggaactcca cggagagact gtcctgctag    360

gacctgcttc cagaagagtt gatcccagcc gtgaaagtgc atgatgcctt cagcgaagca    420

ggcaggaaag gctcaagtga tcctcctgta tcaccctggg tatcaaggcc attcagtgga    480

aaagaacagt ctcttcagca agtggatgaa gttagatctc ttcctcacat catacagaaa    540

aatcaacctc aaatggaaga aatatctaaa tgaagccgaa cacttgataa aaagttcatc    600

agcgtaaata agaagaatcc cctccattac atacaaaaga aaaaataact ggagagatca    660

tctctgctct aagcgtgttt ttaagtctct gcagtcttgg accaagctcg ttttattccc    720

tactctacga gaatctcaag agcaccagga ttctgtttgg agttgccatg gacacagagt    780

tcttaatcca gtactggctt attctcaata cgagagaaag ttgtactgaa gacacgagac    840

ctgagacttg tgtcatttta gcggctgaac cgaccccaac ttcttctgag cggcagtggc    900

gccagaagca gtctggcttt cagtccccat cctgttgacc tggtggaagt catcattgat    960

agagacaccg atgacattcc ccacacaagt gaactgacag gaggaaccaa ggaagcatgt   1020

atctacgaaa gtgtgtcaga acgactttcc aggtttgaag attatgaaaa tgctgaatat   1080

gtcgcttcat atgacagcaa gattaagaaa attgttcatt caattgtgtc atcctttgca   1140

gttggaatat ttggagtttt cctgatcttg ttggatgtgg ctctgatctt tgctgaccta   1200

attttcactg atagcaaagt ttatattcct ttggagtatc gttctatttc tctagctatt   1260

gctttatttt ttctcatgga tgttcttctt cgagtatttg tagaagggag acagcattat   1320

ttttctgatt tacttaacat tttagatact gccgttactg tgattattct gctggttgat   1380

gtcgtttaca ttttttttga cgttaagttt cttaaggata ttcccagatg gacacgttta   1440

tttcgacttc tacgacttat cattctgata agagtttttc gtctggctca tctaaaaaga   1500

caacttggaa agctgataag aaggctggtt tcaggaaaca aaaggtgata cgaaagggat   1560

ggatttgacc tagacctcac ttatattaca gaacgtattg tcgctatgtc atttccatct   1620

tcgggaggcc agtctttcta tcggaatcca attaaggtga aagagcttat gatcctaagc   1680

acttccataa tagggtcagt agaatcatga tcgatgatca taatgtcccc actctacggg   1740

agatggtagc attctccaag gaagtgttgg agtggatggc tcaagattct gaaaacatcg   1800

tagtgattca ctgtaaagga ggcaaaggaa gaaccggaac tatggtttgt gcctgcctga   1860

ttgccagtga aatattttta actgcagagg aaagattgta ctattttgga gaacggcgaa   1920

cagataaaac caatggcact aaatatcagg gagtagaaac tccttctcag aatagatatg   1980

ttggatattt tgcacaagtg aaacatagct acaactggaa tctccctcca agaaaaacac   2040

tgtttataaa aagattagtt atttattcga ttcatggtgt tggaacaggc gatggatatg   2100

atctaaaagt ccaaatagta atgaagaaaa agattgtctt ttcctgtact tccttaaaca   2160

gttgtcgggt atttcatgac actgaaacag acagggtaat aattgatgtg ttcaactgtc   2220

cacctctgta tgatgatgtg aaagtgcaag cttcctcttc ggattttcct aaatactatc   2280

acaactaccc ttttttcttc tggtttaaca catctttaat acaaaataac aagctttatc   2340

tacaaagaaa tgaattggat aatcttcata aacaaaaaac tggaaaattt atcaaccaga   2400

atatgcagta gagacatatt ttgatgagaa atgacttaag ttatgttgta actggtagct   2460

gattaagtat agttccctgc accccttctg ggaaagaatt atgttctttc taaccctgcc   2520

acatagttat atgttctaaa tcttccttgc tggtacatct atattgatat atgtatacac   2580

atgttcttta taaatctatt aaatatatac agaaaaaaaa aaaaaaa                 2627


<210>  3123
<211>  2365
<212>  DNA
<213>  Homosapiens

<400>  3123
agaccagaaa cggaagagag cgcgggggat gtgtttggcg tggggcgcac tgttcagttg     60

ctctcctgga tggctttatg tctccgcggt gtttcctaga gtctcggcgt ttctacctct    120

tcgcaccctt tcctgccacc ctttgtcccc tggaagcccg gagacatcag cggctgcaat    180

tttgctactc gctgctcggc gtggaactgt caggacaaaa aataatatcc aaagatattt    240

tggcactaac ggcgctatct gtagcaagaa agttgagcag tgtgaactgt tgagacttcc    300

aaggagactt cagacaacca agacagtgta aaggaaaaca gagaaaaaga cttgttagac    360

attattaagg gcacgaaagt tgaattgagc acagtaaatg tacaaacaac aaagccaccc    420

aacagaagtt cacttaaaag ctacaactgg cgggcctcaa agagctttag gacatgctcc    480

aaagaagaga aatgagcccc tgagtcctga gttggtggca gctgcatctg ctgctctgtt    540

ttgacaagca aacaagccag aactgctcag gcagctccgt agcatgagga agagtcaggg    600

gcacagagag atggagagag acctagttag tttcaataac aaaatatcag atatgaaaat    660

tgccagatgt gctacagcta gaattaatat aaggccagag catcagattc agtttgacca    720

aggctatgac aattatcctg gcctggagaa gactgctgat cttagaaaca ggaaaaatat    780

attcaggggg aagagatgta atagatttca cattatggca gttactaaag aagcacgtga    840

acagacacat caccttcact ttgggatatg gaatttgata agcagttagc cacagaatat    900

gaacaacccc ttgagaatga gattgaagaa ctgatccagg ggacaaaaga ggggaaactg    960

agagttccca attaataatg aagcagcttc atatctaaga tctctggtgg actttttctg   1020

cccgtggacg ccgctgaaga agcatcgtta aagtctctct tcaccttgcc gtcatgtcta   1080

agtcagcgtc tccaaaagag cccgaacagc tgaggaagct cttcattgga gggttgagct   1140

ttgaaacaac tgatgagagc ctgaggagcc attttgagca atggggaacg ctcacagact   1200

gtgtggtaat gagagatcca aacaccaagc gctccagggg ctttgggttt gtcacatatg   1260

ccactgtgga ggaggtggat gcagctatga atacaacgcc acacaaggtg gatggaagag   1320

ttgtggaacc aaagagagct gtctccagag aagattctca aagaccaggt gcccacttaa   1380

ctgtgaaaaa gatatttgtt ggtggcatta aagaagacac tgaagaacat cacctaagag   1440

attattttga acagtatgga aaaattgaag taattgaaat catgactgac cgaggcagtg   1500

gcaagaaaag gggctttgcc tttgtaacct ttgacgacca tgactccgtg gataagattg   1560

tcattcagaa ataccatact gtgaagggcc acaactgtga agttagaaaa gccctgccaa   1620

agcaagagat ggctagtgct tcatccagcc aaagaggtcg aaggggttct ggaaactttg   1680

gtggtggtcg tggagatggt ttcggtggga atgacaactt tggtcgtgga ggaaacttca   1740

gtggtcgtgg tggctttggt ggcagctgtg gtggtggtgg atatggtggc agtggggatg   1800

gctataatgg atttggtaat gatggaagca attttggagg tggtggaagc tacaatgatt   1860

ttggcaatta caacaatcag tcttcaaatt ttggacccat gaagggagga aattttggag   1920

gcagaagctc tggcccctat ggcggtggag gccaatactt tgcaaaacca caaaaccaag   1980

gtggctatgg cgtttccagc agcagcagta gctatggcag tggcagaaga ttttaattag   2040

gaaacaaagc ttagcaggag aggagagcca gagaagtgac agggaagcta caggttacaa   2100

cagatttgtg aactcagcca agcacagtgg tggcagggcc tagctgctac aaagaagaca   2160

tgttttagac aaatactcat gtgtatgggc aaaaaactcg aggactgtat ttgtgactaa   2220

ttgtataaca ggttatttta gtttctgttc tgtggaaagt gtaaagcatt ccaacaaagt   2280

gttttaatgt agattttttt ttttgcaccc atgctgttga ttgctaaatg taatagtctg   2340

attgtgacgc tgaataaatg tctct                                         2365


<210>  3124
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  3124

Met Ser Lys Ser Ala Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Thr Thr Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Lys Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Pro Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Arg Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Asp 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Cys Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
                245                 250                 255     


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
            260                 265                 270         


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
        275                 280                 285             


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Gln Asn Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Val Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
305                 310                 315                 320 


<210>  3125
<211>  2224
<212>  DNA
<213>  Homosapiens

<400>  3125
agaccagaaa cggaagagag cgcgggggat gtgtttggcg tggggcgcac tgttcagttg     60

ctctcctgga tggctttatg tctccgcggt gtttcctaga gtctcggcgt ttctacctct    120

tcgcaccctt tcctgccacc ctttgtcccc tggaagcccg gagacatcag cggctgcaat    180

tttgctactc gctgctcggc gtggaactgt caggacaaaa aataatatcc aaagatattt    240

tggcactaac ggcgctatct gtagcaagaa agttgagcag tgtgaactgt tgagacttcc    300

aaggagactt cagacaacca agacagtgta aaggaaaaca gagaaaaaga cttgttagac    360

attattaagg gcacgaaagt tgaattgagc acagtaaatg tacaaacaac aaagccaccc    420

aacagaagtt cacttaaaag ctacaactgg cgggcctcaa agagctttag gacatgctcc    480

aaagaagaga aatgagcccc tgagtcctga gttggtggca gctgcatctg ctgctctgtt    540

ttgacaagca aacaagccag aactgctcag gcagctccgt agcatgagga agagtcaggg    600

gcacagagag atggagagag acctagttag gaaaaatata ttcaggggga agagatgtaa    660

tagatttcac attatggcag ttactaaaga agcacgtgaa cagacacatc accttcactt    720

tgggatatgg aatttgataa gcagttagcc acagaatatg aacaacccct tgagaatgag    780

attgaagaac tgatccaggg gacaaaagag gggaaactga gagttcccaa ttaataatga    840

agcagcttca tatctaagat ctctggtgga ctttttctgc ccgtggacgc cgctgaagaa    900

gcatcgttaa agtctctctt caccttgccg tcatgtctaa gtcagcgtct ccaaaagagc    960

ccgaacagct gaggaagctc ttcattggag ggttgagctt tgaaacaact gatgagagcc   1020

tgaggagcca ttttgagcaa tggggaacgc tcacagactg tgtggtaatg agagatccaa   1080

acaccaagcg ctccaggggc tttgggtttg tcacatatgc cactgtggag gaggtggatg   1140

cagctatgaa tacaacgcca cacaaggtgg atggaagagt tgtggaacca aagagagctg   1200

tctccagaga agattctcaa agaccaggtg cccacttaac tgtgaaaaag atatttgttg   1260

gtggcattaa agaagacact gaagaacatc acctaagaga ttattttgaa cagtatggaa   1320

aaattgaagt aattgaaatc atgactgacc gaggcagtgg caagaaaagg ggctttgcct   1380

ttgtaacctt tgacgaccat gactccgtgg ataagattgt cattcagaaa taccatactg   1440

tgaagggcca caactgtgaa gttagaaaag ccctgccaaa gcaagagatg gctagtgctt   1500

catccagcca aagaggtcga aggggttctg gaaactttgg tggtggtcgt ggagatggtt   1560

tcggtgggaa tgacaacttt ggtcgtggag gaaacttcag tggtcgtggt ggctttggtg   1620

gcagctgtgg tggtggtgga tatggtggca gtggggatgg ctataatgga tttggtaatg   1680

atggaagcaa ttttggaggt ggtggaagct acaatgattt tggcaattac aacaatcagt   1740

cttcaaattt tggacccatg aagggaggaa attttggagg cagaagctct ggcccctatg   1800

gcggtggagg ccaatacttt gcaaaaccac aaaaccaagg tggctatggc gtttccagca   1860

gcagcagtag ctatggcagt ggcagaagat tttaattagg aaacaaagct tagcaggaga   1920

ggagagccag agaagtgaca gggaagctac aggttacaac agatttgtga actcagccaa   1980

gcacagtggt ggcagggcct agctgctaca aagaagacat gttttagaca aatactcatg   2040

tgtatgggca aaaaactcga ggactgtatt tgtgactaat tgtataacag gttattttag   2100

tttctgttct gtggaaagtg taaagcattc caacaaagtg ttttaatgta gatttttttt   2160

tttgcaccca tgctgttgat tgctaaatgt aatagtctga ttgtgacgct gaataaatgt   2220

ctct                                                                2224


<210>  3126
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  3126

Met Ser Lys Ser Ala Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Thr Thr Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Lys Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Pro Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Arg Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Asp 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Cys Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
                245                 250                 255     


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
            260                 265                 270         


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
        275                 280                 285             


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Gln Asn Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Val Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
305                 310                 315                 320 


<210>  3127
<211>  1535
<212>  DNA
<213>  Homosapiens

<400>  3127
gaggtggtaa ccgtgatagt agcagctccg gcggcagcaa cagcgactac gagggatggc     60

ggcggctgca gcaggaactg caacatccca gaggtttttc cagagcttct cggatgccct    120

aatcgacgag gacccccagg cggcgttaga ggagctgact aaggctttgg aacagaaacc    180

agatgatgca cagtattatt gtcaaagagc ttattgtcac attcttcttg ggaattactg    240

tgttgctgtt gctgatgcaa agaagtctct agaactcaat ccaaataatt ccactgctat    300

gctgagaaaa ggaatatgtg aataccatga aaaaaactat gctgctgccc tagaaacttt    360

tacagaagga caaaaattag atagtgcaga tgctaatttc agtgtctgga ttaaaaggtg    420

tcaagaagct cagaatggct cagaatctga ggtgtggact catcagtcaa aaatcaagta    480

tgactggtat caaacagaat ctcaagtagt cattacactt atgatcaaga atgttcagaa    540

gaatgatgta aatgtggaat tttcagaaaa agagttgtct gctttggtta aacttccttc    600

tggagaggat tacaatttga aactggaact tcttcatcct ataataccag aacagagcac    660

gtttaaagta ctttcaacaa agattgaaat taaactgaaa aagccagagg ctgtgagatg    720

ggaaaagcta gaggggcaag gagatgtgcc tacgccaaaa caattcgtag cagatgtaaa    780

gaacctatat ccatcatcat ctccttatac aagaaattgg gataaattgg ttggtgagat    840

caaagaagaa gaaaagaatg aaaagttgga gggagatgca gctttaaaca gattatttca    900

gcagatctat tcagatggtt ctgatgaagt gaaacgtgcc atgaacaaat cctttatgga    960

gtcgggtggt acagttttga gtaccaactg gtctgatgta ggtaaaagga aagttgaaat   1020

caatcctcct gatgatatgg aatggaaaaa gtactaaata aattaatttg ctctcatcgt   1080

attgtgtata ttcacctaat gcccattgtg tattgatatt gcattcttga attttgaaca   1140

ctgaatatct ttttgaaaga ttatacttct ttacctcttt gtgctttaga aattattttc   1200

cttcaagtgt tcaagtctaa tgaagaatga agataacatt ttatcacttc tgtccttaaa   1260

gatttcagac atggtgaaac tgaataaagc atgtcatttg ctcctagata gattcattct   1320

atctagttgt ggggatggag aaatctttaa tggtatattt tcggttattg ccttattttt   1380

gatacagtat tctgtcagta atttattaga cctggcagct ttgggtgagc ttagattttt   1440

caccttcagt gttacattgt gtttgctttt aaaaactgct tttgaatgga gttgtaaata   1500

caatttttct atgaagatgt aaaaaaaaaa aaaaa                              1535


<210>  3128
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  3128

Met Ala Ala Ala Ala Ala Gly Thr Ala Thr Ser Gln Arg Phe Phe Gln 
1               5                   10                  15      


Ser Phe Ser Asp Ala Leu Ile Asp Glu Asp Pro Gln Ala Ala Leu Glu 
            20                  25                  30          


Glu Leu Thr Lys Ala Leu Glu Gln Lys Pro Asp Asp Ala Gln Tyr Tyr 
        35                  40                  45              


Cys Gln Arg Ala Tyr Cys His Ile Leu Leu Gly Asn Tyr Cys Val Ala 
    50                  55                  60                  


Val Ala Asp Ala Lys Lys Ser Leu Glu Leu Asn Pro Asn Asn Ser Thr 
65                  70                  75                  80  


Ala Met Leu Arg Lys Gly Ile Cys Glu Tyr His Glu Lys Asn Tyr Ala 
                85                  90                  95      


Ala Ala Leu Glu Thr Phe Thr Glu Gly Gln Lys Leu Asp Ser Ala Asp 
            100                 105                 110         


Ala Asn Phe Ser Val Trp Ile Lys Arg Cys Gln Glu Ala Gln Asn Gly 
        115                 120                 125             


Ser Glu Ser Glu Val Trp Thr His Gln Ser Lys Ile Lys Tyr Asp Trp 
    130                 135                 140                 


Tyr Gln Thr Glu Ser Gln Val Val Ile Thr Leu Met Ile Lys Asn Val 
145                 150                 155                 160 


Gln Lys Asn Asp Val Asn Val Glu Phe Ser Glu Lys Glu Leu Ser Ala 
                165                 170                 175     


Leu Val Lys Leu Pro Ser Gly Glu Asp Tyr Asn Leu Lys Leu Glu Leu 
            180                 185                 190         


Leu His Pro Ile Ile Pro Glu Gln Ser Thr Phe Lys Val Leu Ser Thr 
        195                 200                 205             


Lys Ile Glu Ile Lys Leu Lys Lys Pro Glu Ala Val Arg Trp Glu Lys 
    210                 215                 220                 


Leu Glu Gly Gln Gly Asp Val Pro Thr Pro Lys Gln Phe Val Ala Asp 
225                 230                 235                 240 


Val Lys Asn Leu Tyr Pro Ser Ser Ser Pro Tyr Thr Arg Asn Trp Asp 
                245                 250                 255     


Lys Leu Val Gly Glu Ile Lys Glu Glu Glu Lys Asn Glu Lys Leu Glu 
            260                 265                 270         


Gly Asp Ala Ala Leu Asn Arg Leu Phe Gln Gln Ile Tyr Ser Asp Gly 
        275                 280                 285             


Ser Asp Glu Val Lys Arg Ala Met Asn Lys Ser Phe Met Glu Ser Gly 
    290                 295                 300                 


Gly Thr Val Leu Ser Thr Asn Trp Ser Asp Val Gly Lys Arg Lys Val 
305                 310                 315                 320 


Glu Ile Asn Pro Pro Asp Asp Met Glu Trp Lys Lys Tyr 
                325                 330             


<210>  3129
<211>  1535
<212>  DNA
<213>  Homosapiens

<400>  3129
ccgtgcaccg tgtgtgcgcg cggcgttgaa atgccctgca cgtcggggca gcgggacaga     60

tcccagggtg cccagggagt ctccaagtgc ctcactcctc ccgccgcaaa catgacagag    120

aactccgaca aagttcccat tgccctggtg ggacctgatg acgtggaatt ctgcagcccc    180

ccggcgtacg ctacgctgac ggtgaagccc tccagccccg cgcggctgct caaggtggga    240

gccgtggtcc tcatttcggg agctgtgctg ctgctctttg gggccatcgg ggccttctac    300

ttctggaagg ggagcgacag tcacatttac aatgtccatt acaccatgag tatcaatggg    360

aaattacaag atgggtcaat ggaaatagac gctgggaaca acttggagac ctttaaaatg    420

ggaagtggag ctgaagaagc aattgcagtt aatgatttcc agaatggcat cacaggaatt    480

cgttttgctg gaggagagaa gtgctacatt aaagcgcaag tgaaggctcg tattcctgag    540

gtgggcgccg tgaccaaaca gagcatctcc tccaaactgg aaggcaagat catgccagtc    600

aaatatgaag aaaattctct tatctgggtg gctgtagatc agcctgtgaa ggacaacagc    660

ttcttgagtt ctaaggtgtt agaactctgc ggtgaccttc ctattttctg gcttaaacca    720

acctatccaa aagaaatcca gagggaaaga agagaagtgg taagaaaaat tgttccaact    780

accacaaaaa gaccacacag tggaccacgg agcaacccag gcgctggaag actgaataat    840

gaaaccagac ccagtgttca agaggactca caagccttca atcctgataa tccttatcat    900

caggaagggg aaagcatgac attcgaccct agactggatc acgaaggaat ctgttgtata    960

gaatgtaggc ggagctacac ccactgccag aagatctgtg aacccctggg gggctattac   1020

ccatggcctt ataattatca aggctgccgt tcggcctgca gagtcatcat gccatgtagc   1080

tggtgggtgg cccgtatctt gggcatggtg tgaaatcact tcatatatca tgtgctgtaa   1140

aataagaact agctgaagag acaaccaaag aagcattaag gcaggttgat gctgatggga   1200

ccataaaata tttttacact caacctgagc ggttattctt gacactctta acagaatttt   1260

ttcaattgtt ttccagaact ttagtatatg caaatgtact gaaagggtag ttcaagtcta   1320

aaatgccata acccctttat tatttgttat tttttatttg cattgctttg ccataagtct   1380

tcccttgctt gtatcttcca aagctatttt gaaataaaca tgaaaattta cagtttgcca   1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                              1535


<210>  3130
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  3130

Met Thr Glu Asn Ser Asp Lys Val Pro Ile Ala Leu Val Gly Pro Asp 
1               5                   10                  15      


Asp Val Glu Phe Cys Ser Pro Pro Ala Tyr Ala Thr Leu Thr Val Lys 
            20                  25                  30          


Pro Ser Ser Pro Ala Arg Leu Leu Lys Val Gly Ala Val Val Leu Ile 
        35                  40                  45              


Ser Gly Ala Val Leu Leu Leu Phe Gly Ala Ile Gly Ala Phe Tyr Phe 
    50                  55                  60                  


Trp Lys Gly Ser Asp Ser His Ile Tyr Asn Val His Tyr Thr Met Ser 
65                  70                  75                  80  


Ile Asn Gly Lys Leu Gln Asp Gly Ser Met Glu Ile Asp Ala Gly Asn 
                85                  90                  95      


Asn Leu Glu Thr Phe Lys Met Gly Ser Gly Ala Glu Glu Ala Ile Ala 
            100                 105                 110         


Val Asn Asp Phe Gln Asn Gly Ile Thr Gly Ile Arg Phe Ala Gly Gly 
        115                 120                 125             


Glu Lys Cys Tyr Ile Lys Ala Gln Val Lys Ala Arg Ile Pro Glu Val 
    130                 135                 140                 


Gly Ala Val Thr Lys Gln Ser Ile Ser Ser Lys Leu Glu Gly Lys Ile 
145                 150                 155                 160 


Met Pro Val Lys Tyr Glu Glu Asn Ser Leu Ile Trp Val Ala Val Asp 
                165                 170                 175     


Gln Pro Val Lys Asp Asn Ser Phe Leu Ser Ser Lys Val Leu Glu Leu 
            180                 185                 190         


Cys Gly Asp Leu Pro Ile Phe Trp Leu Lys Pro Thr Tyr Pro Lys Glu 
        195                 200                 205             


Ile Gln Arg Glu Arg Arg Glu Val Val Arg Lys Ile Val Pro Thr Thr 
    210                 215                 220                 


Thr Lys Arg Pro His Ser Gly Pro Arg Ser Asn Pro Gly Ala Gly Arg 
225                 230                 235                 240 


Leu Asn Asn Glu Thr Arg Pro Ser Val Gln Glu Asp Ser Gln Ala Phe 
                245                 250                 255     


Asn Pro Asp Asn Pro Tyr His Gln Glu Gly Glu Ser Met Thr Phe Asp 
            260                 265                 270         


Pro Arg Leu Asp His Glu Gly Ile Cys Cys Ile Glu Cys Arg Arg Ser 
        275                 280                 285             


Tyr Thr His Cys Gln Lys Ile Cys Glu Pro Leu Gly Gly Tyr Tyr Pro 
    290                 295                 300                 


Trp Pro Tyr Asn Tyr Gln Gly Cys Arg Ser Ala Cys Arg Val Ile Met 
305                 310                 315                 320 


Pro Cys Ser Trp Trp Val Ala Arg Ile Leu Gly Met Val 
                325                 330             


<210>  3131
<211>  1538
<212>  DNA
<213>  Homosapiens

<400>  3131
ccgtgcaccg tgtgtgcgcg cggcgttgaa atgccctgca cgtcggggca gcgggacaga     60

tcccagggtg cccagggagt ctccaagtgc ctcactcctc ccgccgcaaa catgacagag    120

aactccgaca aagttcccat tgccctggtg ggacctgatg acgtggaatt ctgcagcccc    180

ccggcgtacg ctacgctgac ggtgaagccc tccagccccg cgcggctgct caaggtggga    240

gccgtggtcc tcatttcggg agctgtgctg ctgctctttg gggccatcgg ggccttctac    300

ttctggaagg ggagcgacag tcacatttac aatgtccatt acaccatgag tatcaatggg    360

aaattacaag atgggtcaat ggaaatagac gctgggaaca acttggagac ctttaaaatg    420

ggaagtggag ctgaagaagc aattgcagtt aatgatttcc agaatggcat cacaggaatt    480

cgttttgctg gaggagagaa gtgctacatt aaagcgcaag tgaaggctcg tattcctgag    540

gtgggcgccg tgaccaaaca gagcatctcc tccaaactgg aaggcaagat catgccagtc    600

aaatatgaag aaaattctct tatctgggtg gctgtagatc agcctgtgaa ggacaacagc    660

ttcttgagtt ctaaggtgtt agaactctgc ggtgaccttc ctattttctg gcttaaacca    720

acctatccaa aagaaatcca gagggaaaga agagaagtgg taagaaaaat tgttccaact    780

accacaaaaa gaccacacag tggaccacgg agcaacccag gcgctggaag actgaataat    840

gaaaccagac ccagtgttca agaggactca caagccttca atcctgataa tccttatcat    900

cagcaggaag gggaaagcat gacattcgac cctagactgg atcacgaagg aatctgttgt    960

atagaatgta ggcggagcta cacccactgc cagaagatct gtgaacccct ggggggctat   1020

tacccatggc cttataatta tcaaggctgc cgttcggcct gcagagtcat catgccatgt   1080

agctggtggg tggcccgtat cttgggcatg gtgtgaaatc acttcatata tcatgtgctg   1140

taaaataaga actagctgaa gagacaacca aagaagcatt aaggcaggtt gatgctgatg   1200

ggaccataaa atatttttac actcaacctg agcggttatt cttgacactc ttaacagaat   1260

tttttcaatt gttttccaga actttagtat atgcaaatgt actgaaaggg tagttcaagt   1320

ctaaaatgcc ataacccctt tattatttgt tattttttat ttgcattgct ttgccataag   1380

tcttcccttg cttgtatctt ccaaagctat tttgaaataa acatgaaaat ttacagtttg   1440

ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                           1538


<210>  3132
<211>  334
<212>  PRT
<213>  Homosapiens

<400>  3132

Met Thr Glu Asn Ser Asp Lys Val Pro Ile Ala Leu Val Gly Pro Asp 
1               5                   10                  15      


Asp Val Glu Phe Cys Ser Pro Pro Ala Tyr Ala Thr Leu Thr Val Lys 
            20                  25                  30          


Pro Ser Ser Pro Ala Arg Leu Leu Lys Val Gly Ala Val Val Leu Ile 
        35                  40                  45              


Ser Gly Ala Val Leu Leu Leu Phe Gly Ala Ile Gly Ala Phe Tyr Phe 
    50                  55                  60                  


Trp Lys Gly Ser Asp Ser His Ile Tyr Asn Val His Tyr Thr Met Ser 
65                  70                  75                  80  


Ile Asn Gly Lys Leu Gln Asp Gly Ser Met Glu Ile Asp Ala Gly Asn 
                85                  90                  95      


Asn Leu Glu Thr Phe Lys Met Gly Ser Gly Ala Glu Glu Ala Ile Ala 
            100                 105                 110         


Val Asn Asp Phe Gln Asn Gly Ile Thr Gly Ile Arg Phe Ala Gly Gly 
        115                 120                 125             


Glu Lys Cys Tyr Ile Lys Ala Gln Val Lys Ala Arg Ile Pro Glu Val 
    130                 135                 140                 


Gly Ala Val Thr Lys Gln Ser Ile Ser Ser Lys Leu Glu Gly Lys Ile 
145                 150                 155                 160 


Met Pro Val Lys Tyr Glu Glu Asn Ser Leu Ile Trp Val Ala Val Asp 
                165                 170                 175     


Gln Pro Val Lys Asp Asn Ser Phe Leu Ser Ser Lys Val Leu Glu Leu 
            180                 185                 190         


Cys Gly Asp Leu Pro Ile Phe Trp Leu Lys Pro Thr Tyr Pro Lys Glu 
        195                 200                 205             


Ile Gln Arg Glu Arg Arg Glu Val Val Arg Lys Ile Val Pro Thr Thr 
    210                 215                 220                 


Thr Lys Arg Pro His Ser Gly Pro Arg Ser Asn Pro Gly Ala Gly Arg 
225                 230                 235                 240 


Leu Asn Asn Glu Thr Arg Pro Ser Val Gln Glu Asp Ser Gln Ala Phe 
                245                 250                 255     


Asn Pro Asp Asn Pro Tyr His Gln Gln Glu Gly Glu Ser Met Thr Phe 
            260                 265                 270         


Asp Pro Arg Leu Asp His Glu Gly Ile Cys Cys Ile Glu Cys Arg Arg 
        275                 280                 285             


Ser Tyr Thr His Cys Gln Lys Ile Cys Glu Pro Leu Gly Gly Tyr Tyr 
    290                 295                 300                 


Pro Trp Pro Tyr Asn Tyr Gln Gly Cys Arg Ser Ala Cys Arg Val Ile 
305                 310                 315                 320 


Met Pro Cys Ser Trp Trp Val Ala Arg Ile Leu Gly Met Val 
                325                 330                 


<210>  3133
<211>  747
<212>  DNA
<213>  Homosapiens

<400>  3133
atgggactgg gcgctgtgga gcaggtagcg gagctcctcc gggaggctcg ggctgcccag     60

gagccggcgg cgggggtggg ggggcaggct caggcatggc gggcctcagg tcctaagccc    120

tgcccctcag ggaggcagct aaggcccggc gagaaatcga gcacagcagc tggtggccaa    180

gatcttggct ttgcagatgc tgccaggaac cccatactat cagccatggt caaccccacc    240

gtgttcttca acatggctgt caatgatgag cccttgtgcc acgtctcctt tgagctgtat    300

gcagacaagt ttccaaagac agcagaaaac tttcgtgctc tgagcactgg agagaaagga    360

tttggttaca agggtttctg cttttacaga attattccag ggtttatgtg gtttatgtgt    420

cagggcagtg acttcacaca ccataatggc actggtggca agtccatcta tggagagaaa    480

tttgatgacg agaacttcat cctgaagcat acaggtcctg aaccctcaca ttcccaaacc    540

aattacttat ccatggcaaa tgctggaccc aacacaaatg gttcccagtt tttcctctgc    600

actgccaaga ctgagtggtt ggatggcaca catgtggtct ttggcaaggt gaaagaaggc    660

atcaatattg tggaggccat ggagcgcttt ggatctagga atggcaagac cagcaagatc    720

accattgttg actgtggaca actctaa                                        747


<210>  3134
<211>  2934
<212>  DNA
<213>  Homosapiens

<400>  3134
ctgctgcgag ccgagccggg cggcggcggc agtggcggca gtggcggcag cggcagcagt     60

tgcagcagtg gtggccagag cggatgcttg cgggctccct gcggctccac tagttttctt    120

cgccccgccc agccgcccac tcttctcggc tagggaagaa gaccagaggg tgctcagctg    180

gaaaactctg gtgtctcagc ttagggcctc ctccgggaag agctaactgc tcccaggtga    240

agccggtgcc cgcgggcggt ccgtacaccc cgcagccggc tcgcaccgct cgagagcctc    300

ggccgctgtg tcttccacgt ctgcagctca gccagggcgc gcagggcgag tggggtccac    360

tggcgggtaa aggggaccag gacggcgagg atggacgcac agacctggcc cgtgggcttt    420

cgctgcctcc tccttctggc cctggttggg tccgcccgca gcgagggcgt gcagacctgc    480

gaagaagttc ggaaactttt ccagtggcgg ctgctgggag ctgtcagggg gctgccggat    540

tcgccgcggg caggacctga tcttcaggtt tgcatatcca aaaagcctac atgttgcacc    600

aggaagatgg aggagagata tcagattgcg gctcgccagg atatgcagca gtttcttcaa    660

acgtccagct ctacattaaa gtttctaata tctcgaaatg cggctgcttt tcaagaaacc    720

cttgaaactc tcatcaaaca agcagaaaat tacaccagta tacttttttg cagtacctac    780

aggaacatgg ccttggaggc tgctgcttcg gttcaggagt tcttcactga tgtggggctg    840

tatttatttg gtgcggatgt taatcctgaa gaatttgtaa acagattttt tgacagtctt    900

tttcctctgg tctacaacca cctcattaac cctggtgtga ctgacagttc cctggaatac    960

tcagaatgca tccggatggc tcgccgggat gtgagtccat ttggtaatat tccccaaaga   1020

gtaatgggac agatggggag gtccctgctg cccagccgca cttttctgca ggcactcaat   1080

ctgggcattg aagtcatcaa caccacagac tatctgcact tctccaaaga gtgcagcaga   1140

gccctcctga agatgcaata ctgcccgcac tgccaaggcc tggcgctcac taagccttgt   1200

atgggatact gcctcaatgt catgcgaggc tgcctggcgc acatggcgga gcttaatcca   1260

cactggcatg catatatccg gtcgttggaa gaactctcgg atgcaatgca tggaacatac   1320

gacattggac acgtgctgct gaactttcac ttgcttgtta atgatgctgt gttacaggct   1380

cacctcaatg gacaaaaatt attggaacag gtaaatagga tttgtggccg ccctgtaaga   1440

acacccacac aaagcccccg ttgttctttt gatcagagca aagagaagca tggaatgaag   1500

accaccacaa ggaacagtga agagacgctt gccaacagaa gaaaagaatt tatcaacagc   1560

cttcgactgt acaggtcatt ctatggaggt ctagctgatc agctttgtgc taatgaatta   1620

gctgctgcag atggacttcc ctgctggaat ggagaagata tagtaaaaag ttatactcag   1680

cgtgtggttg gaaatggaat caaagcccag tctggaaatc ctgaagtcaa agtcaaagga   1740

attgatcctg tgataaatca gattattgat aaactgaagc atgttgttca gttgttacag   1800

ggtagatcac ccaaacctga caagtgggaa cttcttcagc tgggcagtgg tggaggcatg   1860

gttgaacaag tcagtgggga ctgtgatgat gaagatggtt gcgggggatc aggaagtgga   1920

gaagtcaaga ggacactgaa gatcacagac tggatgccag atgatatgaa cttcagtgat   1980

gtaaagcaaa tccatcaaac agacactggc agtactttag acacaacagg agcaggatgt   2040

gcagtggcga ctgaatctat gacattcact ctgataagtg tggtgatgtt acttcccggg   2100

atttggtaac tgaactcttc tgtcctgaca taccttactg aagtctcgat ttcttctctc   2160

tctgcatatg cctggaataa gagatccttt ttcaatgtaa caattatatt tatgaaaaga   2220

tatgttacac taacttctca gaagccaagc tgaaatattc ataaagtccc taaaactcaa   2280

cgtttaaatg acacacttta aaaatatgtc ttttttcaat ctaactgaaa accttcttaa   2340

cttctaatat attaaatctg aagatgtgaa gggcacagaa gtgactttga ataagaagaa   2400

tttagtgtat ctgtaatttt attatcaatt ccaagcccct tcctttctaa attaaaaatg   2460

ttttcatttg aaagtgtatt tgccagacaa tgaaaacagt atgcagtatt tcttaaagta   2520

ttgaaattag aatatcatga aataaatcaa aacatacaat ggcaagtagt atgcatgcat   2580

attcaagaga ctcttccatt tttgcaagct gtagaaggaa atgtctgaat gtctataagt   2640

tatggggtag attcttgaga agcatttcat ataatttcac tgaagaacct tgataatttt   2700

gacccactgt aacttagcca ctgatgaacc ttaaagctga gtattttatt aacacctgat   2760

ttgtattcca ttatattcaa aatgcatctt tggtattgtg cctctgctcc catctctctc   2820

tttgcctcat agatttagct atgttgggaa gcacatgctt gctctaggaa tatctccaat   2880

aaagctgtta actatttggt ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa         2934


<210>  3135
<211>  572
<212>  PRT
<213>  Homosapiens

<400>  3135

Met Asp Ala Gln Thr Trp Pro Val Gly Phe Arg Cys Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Val Gly Ser Ala Arg Ser Glu Gly Val Gln Thr Cys Glu Glu 
            20                  25                  30          


Val Arg Lys Leu Phe Gln Trp Arg Leu Leu Gly Ala Val Arg Gly Leu 
        35                  40                  45              


Pro Asp Ser Pro Arg Ala Gly Pro Asp Leu Gln Val Cys Ile Ser Lys 
    50                  55                  60                  


Lys Pro Thr Cys Cys Thr Arg Lys Met Glu Glu Arg Tyr Gln Ile Ala 
65                  70                  75                  80  


Ala Arg Gln Asp Met Gln Gln Phe Leu Gln Thr Ser Ser Ser Thr Leu 
                85                  90                  95      


Lys Phe Leu Ile Ser Arg Asn Ala Ala Ala Phe Gln Glu Thr Leu Glu 
            100                 105                 110         


Thr Leu Ile Lys Gln Ala Glu Asn Tyr Thr Ser Ile Leu Phe Cys Ser 
        115                 120                 125             


Thr Tyr Arg Asn Met Ala Leu Glu Ala Ala Ala Ser Val Gln Glu Phe 
    130                 135                 140                 


Phe Thr Asp Val Gly Leu Tyr Leu Phe Gly Ala Asp Val Asn Pro Glu 
145                 150                 155                 160 


Glu Phe Val Asn Arg Phe Phe Asp Ser Leu Phe Pro Leu Val Tyr Asn 
                165                 170                 175     


His Leu Ile Asn Pro Gly Val Thr Asp Ser Ser Leu Glu Tyr Ser Glu 
            180                 185                 190         


Cys Ile Arg Met Ala Arg Arg Asp Val Ser Pro Phe Gly Asn Ile Pro 
        195                 200                 205             


Gln Arg Val Met Gly Gln Met Gly Arg Ser Leu Leu Pro Ser Arg Thr 
    210                 215                 220                 


Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile Asn Thr Thr Asp 
225                 230                 235                 240 


Tyr Leu His Phe Ser Lys Glu Cys Ser Arg Ala Leu Leu Lys Met Gln 
                245                 250                 255     


Tyr Cys Pro His Cys Gln Gly Leu Ala Leu Thr Lys Pro Cys Met Gly 
            260                 265                 270         


Tyr Cys Leu Asn Val Met Arg Gly Cys Leu Ala His Met Ala Glu Leu 
        275                 280                 285             


Asn Pro His Trp His Ala Tyr Ile Arg Ser Leu Glu Glu Leu Ser Asp 
    290                 295                 300                 


Ala Met His Gly Thr Tyr Asp Ile Gly His Val Leu Leu Asn Phe His 
305                 310                 315                 320 


Leu Leu Val Asn Asp Ala Val Leu Gln Ala His Leu Asn Gly Gln Lys 
                325                 330                 335     


Leu Leu Glu Gln Val Asn Arg Ile Cys Gly Arg Pro Val Arg Thr Pro 
            340                 345                 350         


Thr Gln Ser Pro Arg Cys Ser Phe Asp Gln Ser Lys Glu Lys His Gly 
        355                 360                 365             


Met Lys Thr Thr Thr Arg Asn Ser Glu Glu Thr Leu Ala Asn Arg Arg 
    370                 375                 380                 


Lys Glu Phe Ile Asn Ser Leu Arg Leu Tyr Arg Ser Phe Tyr Gly Gly 
385                 390                 395                 400 


Leu Ala Asp Gln Leu Cys Ala Asn Glu Leu Ala Ala Ala Asp Gly Leu 
                405                 410                 415     


Pro Cys Trp Asn Gly Glu Asp Ile Val Lys Ser Tyr Thr Gln Arg Val 
            420                 425                 430         


Val Gly Asn Gly Ile Lys Ala Gln Ser Gly Asn Pro Glu Val Lys Val 
        435                 440                 445             


Lys Gly Ile Asp Pro Val Ile Asn Gln Ile Ile Asp Lys Leu Lys His 
    450                 455                 460                 


Val Val Gln Leu Leu Gln Gly Arg Ser Pro Lys Pro Asp Lys Trp Glu 
465                 470                 475                 480 


Leu Leu Gln Leu Gly Ser Gly Gly Gly Met Val Glu Gln Val Ser Gly 
                485                 490                 495     


Asp Cys Asp Asp Glu Asp Gly Cys Gly Gly Ser Gly Ser Gly Glu Val 
            500                 505                 510         


Lys Arg Thr Leu Lys Ile Thr Asp Trp Met Pro Asp Asp Met Asn Phe 
        515                 520                 525             


Ser Asp Val Lys Gln Ile His Gln Thr Asp Thr Gly Ser Thr Leu Asp 
    530                 535                 540                 


Thr Thr Gly Ala Gly Cys Ala Val Ala Thr Glu Ser Met Thr Phe Thr 
545                 550                 555                 560 


Leu Ile Ser Val Val Met Leu Leu Pro Gly Ile Trp 
                565                 570         


<210>  3136
<211>  4370
<212>  DNA
<213>  Homosapiens

<400>  3136
ggtcgccctc agtcccaccc ggtgcctacg gggccgcatc gccgcccggc tcggcccggc     60

ccatgcccag ggccgctgct ccctcagttg ccgccgccgc cgccggcgcc cagggggccg    120

ccgcggctgt gaggtggggg cggcagcggg aggcggcggg gcgggccgcc ggggccgggg    180

ctgggggcgc agcgcggccg gcgtaggtct atgtcgcggg cggcggcggc ggcggcggcc    240

gcggagggac gatgcgcgag tacaaagtgg tggtgctggg ctcgggcggg gtaggcaaat    300

ccgccctgac cgtgcagttc gtgaccggca ccttcatcga gaaatacgac cccaccatcg    360

aggacttcta ccgcaaggag atcgaggtgg attcgtcgcc gtcggtgctg gagatcctgg    420

acacggcggg caccgagcag ttcgcgtcca tgcgggacct gtacatcaag aacggccagg    480

gcttcatcct cgtctacagc ctcgtcaacc agcagagctt ccaggacatc aagcccatgc    540

gggaccagat catccgcgtg aagcggtatg agaaagtgcc agtcatcttg gttgggaaca    600

aagtggacct ggaaagtgag agagaagtat cgtccagcga aggcagagcc cttgctgaag    660

agtggggctg cccctttatg gaaacttccg ctaagagtaa aacaatggtg gacgaactct    720

ttgcagaaat tgtgaggcag atgaactatg ctgctcagcc tgacaaagat gacccatgct    780

gttctgcatg taacatacaa tagcatccaa atatggctgt cctggatggg atttgcccaa    840

tgtcgtaggt gatagaaaac tcgcctactc cactgcagaa cttgcagaat gcgtggtgtt    900

aatctacaga gaactgcagc ccttattcag aattgagcag tgattgtcag ttgatatctc    960

tgagtaacat ttgggttcag taactacagt tttcaccatt tgtcctcagt ctcctttatg   1020

catctgcaac tttaaggcat agtccatcga tctacagggt gatctcattt gaaagctatg   1080

atggcattgt cgctgagttg acagaagcaa ctattgtaca aattaaaaat aaccataagg   1140

gagaaaccag aagaattcct ctgaccactt acaattaaaa tattttgtct tctttaaaaa   1200

aataagtaaa ggagaaatat tttcctacaa gagtactgaa tttcaggaaa tgggatagag   1260

cttctaacca gtgtattccg tcaagtaaga taataacagc tgacctgcca acagcattac   1320

agggagattc tttgctcagc taacacattt ctgtttttca aaattgatgc ttaattgtag   1380

ctgttattct aatttgtgac atggaactaa ctcatgcttc aatccttgat agagcaaaac   1440

tcagaacagg ttatgtaaaa atatagtctg gctttagaat ttgttaattc acctgctttg   1500

ccacagaaaa tggaggcttt cacaagggtt tgatcagaat taaaacccca aaccagccct   1560

ctgttagggg tggtctttat aactttactg aacaagaggg aagcaactgt gatgggaaga   1620

gattacctag ccttactaac aagaagcatt ctaatagata aactagtacc atcatgtaag   1680

gaagatgaag ccatgttgca tccacatgtt cccgtttgca gaaacctcac aggacagtac   1740

gaatatctgg catttttaag ttcattaaag cagcaaattc cttctcgcct ttaagggcta   1800

tggttgtagt gtgacccgtg gctaacctgc tttcaaaatc aagtatttgc tgtagcagag   1860

ctttattgca ggcattttaa aaattgaata accatgtgaa ataatttggg cttaaaagtg   1920

aacataaatt atagagtgga aggtaaggga caaaagcctt ttacctttaa ttttcctgga   1980

gaattatata taggttttct tagaacaatt ttaccctgat tactgaagcg tcaaataaag   2040

ctggagtgaa aattttgttt tgaaaaggtg ctcaagctct gacatttttg gttttcatag   2100

tcgtgaagta tttatcattt gcatgactaa tggcacagga aaaacctatt cataagtttt   2160

acaatcaagt atagaggggt cttcagctaa cttagttata cataaatgct gaaaagatta   2220

tcttgagctg ggccttggga gaagaatttg gccttcagaa ctgcaatatc actgagcctg   2280

cgatctatac accaccccac attttgttgg tttcacagtc ttgtgcaagt aacctctggt   2340

cttacgtgtg taactgagag aagagtgtgt gtttgtgtgt gcatgtgtgt ttattgttcc   2400

taagaatttg gcacaagtca gagataattg cctatactaa gaatctatac tgcagaatat   2460

agtgtatcaa aaactttttt cttttaaatt attaaagtgt cttttatact tttatgaaat   2520

cattggtagc cccccaagtg tttaataact ggcattaagc ttagagggtg aaaaaaaaaa   2580

aaaaaagatt gatagtattt ttcataatga aaaaactgaa gagatacgtg aatgaaacca   2640

ggccatagct gtcataaatc tttgactttt gaatatttac attcttcagt ataatttttt   2700

ataatcctca attatgaacc accttgttta taggacaaaa aaatttaacc aattttattg   2760

aaacgaattt cactgtgtaa aagttggttt gattcaaaca tgtagagaag ttgtagattc   2820

aagatatatg atttctctat ggaaataaaa atatttgtta gtgaattggt tgagttttga   2880

ttcctctaac ttctcagaat gattctttag aattctataa ttcatagcaa tttttgacaa   2940

gtaagattgc aaaatagaaa tatctataaa gattccacag tttgacatta tggcttgcta   3000

tgcagatgtg aaaataggtt aaataatatg aaagatatgg cagaatgtaa agtggaaaag   3060

atgacctaaa attttgagtt gtattaatag ttaaaaacat ttgtgtcaga tgacagggtg   3120

ggcttttact gtcaagacat gaataagaac tgatctggct gcctgatgag tgtttccacg   3180

cagccctgca tatttagtga ccaaggcatc aaggacatcc cgaaactgga aattcatatc   3240

catctggtat gaatatataa ctcagctggc aaatgaatgt gtttgttgag atattacagt   3300

aataaaacac ttaagaacag gaagattaca tttgttggca tacgaaacct tagtggctac   3360

agaagaaagt tgaccttgtg tcactattta ttttatgccc tgatcagact agcaacttag   3420

ataagtgaaa gtttttctaa catgccttaa aaatattatg gtttgatcca aagacccact   3480

ttttctttag ctcttgtgat aagattttgt tttttttact tttatacaaa ggcagcatct   3540

ttgaattttt ttttcttttg atgttgcaac ttttgggttc ttttaaactg tgatagtgat   3600

ggtaactgat gcctttcatt ttgttcaact tacacaaaac aagccagcat ctgatcaaaa   3660

gtattacata aaatattttc ttaaactatt gaaaggtgct ttgatgattt tctcctttgg   3720

tttgtagaat taggactgaa cttttgactc aaattgctac agttgccatc acctttctgt   3780

ggtaatacta ctgatatttg cttttctata taaagaaatg ttgcctaagg ctgtctggta   3840

tttcttttca agggttttcc agtatgaatg ttaatgttgt cagtgtatgt atgaatatga   3900

aagtgctttg ttttgtttgt tgctgttttt tgtttatgtg tgtgttttta atttttttgt   3960

tcttatcagc agtcttgtgt tagcactggg taagctttaa ttgtccctta gccaatcaaa   4020

cattaaggac tatggaggtc tttttttttt tatttaacat gtcattgttc atctattaaa   4080

tcttgatcag ggtttcaaga atgactgcag tgggttttgg aaacagactt atcattattg   4140

atttgaggtt tcccagagat atagttcaca gttaattgtt gcgctctaat acaactgacc   4200

atttaaaatt gaacaagttt attgttttgt aacaatgtca gttgttaaac cttgacattt   4260

caattaaaac atgaattgta gttataactc aatgcaaatt caacagttgt atttggagtt   4320

aaattatttt aacaaataaa tttatttaat gaagaaaaaa aaaaaaaaaa              4370


<210>  3137
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  3137

Met Arg Glu Tyr Lys Val Val Val Leu Gly Ser Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Val Gln Phe Val Thr Gly Thr Phe Ile Glu Lys Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Phe Tyr Arg Lys Glu Ile Glu Val Asp Ser 
        35                  40                  45              


Ser Pro Ser Val Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe 
    50                  55                  60                  


Ala Ser Met Arg Asp Leu Tyr Ile Lys Asn Gly Gln Gly Phe Ile Leu 
65                  70                  75                  80  


Val Tyr Ser Leu Val Asn Gln Gln Ser Phe Gln Asp Ile Lys Pro Met 
                85                  90                  95      


Arg Asp Gln Ile Ile Arg Val Lys Arg Tyr Glu Lys Val Pro Val Ile 
            100                 105                 110         


Leu Val Gly Asn Lys Val Asp Leu Glu Ser Glu Arg Glu Val Ser Ser 
        115                 120                 125             


Ser Glu Gly Arg Ala Leu Ala Glu Glu Trp Gly Cys Pro Phe Met Glu 
    130                 135                 140                 


Thr Ser Ala Lys Ser Lys Thr Met Val Asp Glu Leu Phe Ala Glu Ile 
145                 150                 155                 160 


Val Arg Gln Met Asn Tyr Ala Ala Gln Pro Asp Lys Asp Asp Pro Cys 
                165                 170                 175     


Cys Ser Ala Cys Asn Ile Gln 
            180             


<210>  3138
<211>  6019
<212>  DNA
<213>  Homosapiens

<400>  3138
gacctcccac aactggagca gccgggaaca gctctgacca cagtggttcc ggggagaagc     60

ctttccagga cccatgtgta ggcacaactg ttttccctga tcaggatact tgcggcactc    120

aacagaggaa agaaattcct aagggaacac tgctcagaaa gtactgcagc atgtcttcaa    180

atgcctgagg atcaagttgg aaaactagaa gcaacagaaa acacaataag cgcaatggcg    240

gcggccgcgg cggagcagca acagttctac ctgctcctgg gaaacctgct cagccccgac    300

aatgtggtcc ggaaacaggc agaggaaacc tatgagaata tcccaggcca gtcaaagatc    360

acattcctct tacaagccat cagaaataca acagctgctg aagaggctag acaaatggcc    420

gccgttctcc taagacgtct cttgtcctct gcatttgatg aagtctatcc agcacttccc    480

tctgatgttc agactgccat caagagtgag ctactcatga ttattcagat ggaaacacaa    540

tctagcatga ggaaaaaagt ttgtgatatt gcggcagaac tggccaggaa tttaatagat    600

gaggatggca ataaccagtg gcccgaaggt ttgaagttcc tttttgattc agtcagctct    660

caaaatgtgg gactgcggga agctgccctt cacattttct ggaactttcc tggaattttt    720

gggaaccagc aacaacacta tttagatgtc atcaaacgaa tgttagttca gtgtatgcaa    780

gatcaggaac acccgtcgat caggacgtta tctgctagag ctacagctgc atttatactt    840

gcaaatgagc ataatgttgc tctgttcaaa cattttgcag acttgctacc gggattccta    900

caggcggtaa atgactcgtg ctaccagaat gatgattctg tcctaaaatc cctcgttgag    960

attgcagata ctgttccaaa gtatttgcgt cctcacttgg aagcaactct acagctaagt   1020

ctaaagttgt gtggagacac tagcctcaac aatatgcaac gccagcttgc ccttgaagtg   1080

atcgtcaccc tctctgagac tgcagctgct atgttaagaa aacataccaa tattgttgca   1140

cagactattc ctcagatgtt agcaatgatg gttgatttgg aagaagatga ggactgggca   1200

aatgcagatg aactagaaga tgatgatttt gacagcaatg cagttgcagg cgagagtgct   1260

ctagatcgaa tggcttgcgg acttggtgga aagctcgttc tgccgatgat caaggaacac   1320

attatgcaaa tgcttcaaaa tcctgactgg aaataccggc atgcaggatt gatggcctta   1380

tctgccattg gtgaagggtg ccaccagcaa atggaaggaa ttctaaatga gatcgtaaat   1440

tttgttttac tttttctcca ggatcctcat ccaagagtaa ggtatgcagc ctgtaatgcc   1500

gtgggacaga tggctacaga ttttgcacct ggtttccaaa agaaatttca tgagaaggtg   1560

attgcagctc tgctgcagac catggaagac caaggcaatc aacgtgtgca ggcccatgca   1620

gctgctgccc tcattaactt tactgaagac tgtcccaagt cactacttat tccatacttg   1680

gataatttgg tgaaacatct gcattccatt atggtactga agcttcaaga gctgattcag   1740

aaaggcacca agttagtttt ggaacaagtt gtgacatcca ttgcatcagt tgccgatact   1800

gcagaagaaa aatttgtccc ctactatgat ttatttatgc catcactgaa gcacatcgtt   1860

gagaatgcgg ttcaaaaaga actgagactt ctgagaggaa aaactattga atgcattagc   1920

ctcattggtc tggctgttgg gaaggaaaaa ttcatgcagg atgcatcaga tgtgatgcag   1980

cttttgttaa agacccagac agacttcaat gatatggaag atgatgatcc tcagatctct   2040

tacatgatct cagcatgggc cagaatgtgc aaaatccttg gaaaagaatt tcagcaatac   2100

cttccagtgg ttatggggcc tttaatgaag acggcttcaa ttaagcccga agtagccctt   2160

ttagataccc aagacatgga gaatatgagt gatgatgatg gttgggaatt tgtgaacctt   2220

ggagatcagc aaagctttgg tattaaaact gcaggactag aagaaaaatc aactgcttgc   2280

cagatgttgg tttgctatgc taaggagtta aaggaaggct ttgtggagta caccgaacag   2340

gttgtcaaac tgatggtccc tttactgaaa ttttatttcc acgatggtgt tcgagtggca   2400

gcagcggaat ccatgcctct tctcctggag tgtgcaagag tccgtggtcc tgagtatctc   2460

acacagatgt ggcattttat gtgtgatgct ctaattaagg ccattggtac agaaccagat   2520

tcagacgtcc tctcagaaat aatgcattct tttgcaaagt gcattgaagt aatgggagat   2580

ggatgcctta ataatgaaca ctttgaagaa ctgggaggta tattgaaagc aaagcttgaa   2640

gaacatttta aaaatcaaga attacgacaa gttaaaagac aagatgaaga ctatgatgaa   2700

caggtcgaag agtcactaca agatgaggat gataatgatg tttatattct gaccaaagtg   2760

tcagatattt tacactcaat attcagtagc tacaaagaaa aggtgttacc atggtttgaa   2820

cagctgcttc cattaattgt caacctcatt tgtccacata gaccatggcc agacagacaa   2880

tggggattat gcatctttga tgatgtcata gaacactgta gtccagcctc atttaaatac   2940

gcagaatatt tcttaagacc aatgctccaa tatgtatgtg acaacagccc agaagtcagg   3000

caagcagctg catatggcct gggagtcatg gcacagtacg gtggagataa ttatcgccct   3060

ttttgtacag aagcacttcc cctgctggta agagttattc agtctgcgga ttctaagacc   3120

aaagaaaatg tcaatgctac agagaactgc atctcagcag tagggaaaat catgaagttc   3180

aagcctgact gtgtaaacgt tgaagaggtc cttccacact ggttgtcttg gcttccacta   3240

catgaagata aagaagaagc tgttcagact ttcaattatc tgtgtgacct gattgaaagt   3300

aatcatccaa ttgttcttgg cccaaacaat accaatctgc ccaaaatatt tagtataatt   3360

gcggaaggag aaatgcacga ggcaattaaa catgaagatc cttgtgccaa acgtctggcc   3420

aatgtcgttc gccaagtaca gacttctgga ggactgtgga ctgagtgcat agcacagctc   3480

agtcctgagc agcaggccgc cattcaggag ctcctgaact ctgcgtgaag ggccttaatg   3540

tcacccacca gaaaactaac tccaaataaa cgcttaccct ttcctttagg tttctttgtt   3600

ttgtttttga gcaaaagaga tcggtagtgt tgtgtgtagg ccattcttct ggagagccac   3660

aagcaggaag agcagcgctg tgttgcagaa tggagtttcc atggatttct accagaccac   3720

tgaaggagtt cctggaagcc ctgcggtagc tagcactgaa gactattttt ctattggtat   3780

aacccgccca cctgaagggg aaagggaaat caaattaatt tttctcgtta gacataagga   3840

aatttaagga aaaacagctt taagaacagt tactcagcgt agatgtgtgt tcacacaaat   3900

tgctctgcat tcagtgttca ttgtgaattg ggagtgtgag tctttctgta gggtagaaag   3960

aagcctccta cccagcaaac cagtagaccc aaaagttgaa aaaaactgat gacagacaac   4020

aagcatgaag atggcatatt tgatgtcact ttggttcttt ttcccagaag gcttatacag   4080

tgactcagtc gggaagcttt ccagcttcca gcccttgaat gtgaagtgtc attggcatgt   4140

ctggcagtag tctctcattc actcctcaat aaacaacatt gaatacaaaa gaggcttgtg   4200

taaaaactca gtactgtctg gcttggattc atttcatgtt tttaatataa gaatgatcta   4260

atattttttt aaagtaatag ctatcagtaa tagctgagtg ttttttcccc taatattttc   4320

cttgtgcaat tcagacttaa gcatcgagtt tttaccatct tccactttaa gctaagttat   4380

gatacctatt ccattcacaa ttggtgttct ttttaaggtt tgcaaatttc agccaatttt   4440

gtagctaaga ttgttctgat cagctcaaaa agatttggct tagtgttttc attgcaaatt   4500

ataattgctg tagagccaca cacaactttt gaacttttaa ttataagtgt tatggctaaa   4560

gttatttact gaaaatttca gtaaaatgtg tgaatgtttc tttatgtatt aacctcatag   4620

cagtaaatga cttgctgttg tttaattttt ctaaggcatc ttaatagact tctgttgaaa   4680

acttcagtgt taacattttt atagtttgta ctaaatttaa ccgtgatata aaaatgaatt   4740

ttatgcatag atcagaattt taaattaaag gttttttctt taaatgattt gtattacttt   4800

attaaaacta aatctgaaat ggaatagaaa atagaatgga ttacatacag atggtttcct   4860

tgttagcaga tgcccttcaa atatatttta cgtttgcagc acaacaccat tgcccggagg   4920

cttccgaatc tagcaaagca gcatattaaa tgactccacc tgcgcagtcc ttgtgttcag   4980

tggatgaata cctgtgggct cttgtaatgt gtggtaatat ttggagcttt atagcctgta   5040

ttccttggga gaaaaaaatg ggaattggag taaaaagtgt gtcaagacaa cccctttctg   5100

ctttcttatg tagcatctgc aaagccgatt catgtactga tgccaatcag ctagagcaat   5160

gtaggctttt tttaatttaa attattacta cactttatta ctacacttgc agaaaagaaa   5220

catgttaaaa tcatggcaca cctgcagaat ttcagatgac agtgtggtca gaagatgttt   5280

tttgggagaa cctagtgttt gctgggcact atgctaagca ctttgggagc aagaacctcc   5340

taccttccag tttaaacact agtggtattg tcagatgccg ttagtatctg agatgtactt   5400

acagcagggt tctaagagct ctgaaagaag cgctctgtta gatgcagact ggcagcatcc   5460

tccttgataa aagcagaaaa gcaaagaggt aattggagtt gaatcaagtt aatagggaag   5520

gttggtagta aatgctgtta gtgtgacatg attctgaaac ccagagctca gaactaactg   5580

tgagatgtac catgaactaa caattctttg aaaggacctg cagaagcatt tttaatacct   5640

cattctgtct atgcaagatg aaaatccatg gagttttttc ttggcttttg taccaaattt   5700

aggggtcttg catgtcagca agtgatatat attgtttata aatgcaagct atttctggag   5760

gggaaaaatg tgtgtggctc ttacgttttc tgggaatttt gtaacaagtt acacgcacaa   5820

gtgttagaaa ctttggcata actcaatttg gagtattttt taaatgctgt atctttaaag   5880

aaaagtaaaa ttgtcttaaa tctaattgac acttctgtaa tgagaggcaa ccttataact   5940

ctggagttgt agtttgacag aaccatcagt aaagacataa gcaaataaat ggtcttggtg   6000

caaaaaaaaa aaaaaaaaa                                                6019


<210>  3139
<211>  1115
<212>  PRT
<213>  Homosapiens

<400>  3139

Met Pro Glu Asp Gln Val Gly Lys Leu Glu Ala Thr Glu Asn Thr Ile 
1               5                   10                  15      


Ser Ala Met Ala Ala Ala Ala Ala Glu Gln Gln Gln Phe Tyr Leu Leu 
            20                  25                  30          


Leu Gly Asn Leu Leu Ser Pro Asp Asn Val Val Arg Lys Gln Ala Glu 
        35                  40                  45              


Glu Thr Tyr Glu Asn Ile Pro Gly Gln Ser Lys Ile Thr Phe Leu Leu 
    50                  55                  60                  


Gln Ala Ile Arg Asn Thr Thr Ala Ala Glu Glu Ala Arg Gln Met Ala 
65                  70                  75                  80  


Ala Val Leu Leu Arg Arg Leu Leu Ser Ser Ala Phe Asp Glu Val Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ser Asp Val Gln Thr Ala Ile Lys Ser Glu Leu Leu 
            100                 105                 110         


Met Ile Ile Gln Met Glu Thr Gln Ser Ser Met Arg Lys Lys Val Cys 
        115                 120                 125             


Asp Ile Ala Ala Glu Leu Ala Arg Asn Leu Ile Asp Glu Asp Gly Asn 
    130                 135                 140                 


Asn Gln Trp Pro Glu Gly Leu Lys Phe Leu Phe Asp Ser Val Ser Ser 
145                 150                 155                 160 


Gln Asn Val Gly Leu Arg Glu Ala Ala Leu His Ile Phe Trp Asn Phe 
                165                 170                 175     


Pro Gly Ile Phe Gly Asn Gln Gln Gln His Tyr Leu Asp Val Ile Lys 
            180                 185                 190         


Arg Met Leu Val Gln Cys Met Gln Asp Gln Glu His Pro Ser Ile Arg 
        195                 200                 205             


Thr Leu Ser Ala Arg Ala Thr Ala Ala Phe Ile Leu Ala Asn Glu His 
    210                 215                 220                 


Asn Val Ala Leu Phe Lys His Phe Ala Asp Leu Leu Pro Gly Phe Leu 
225                 230                 235                 240 


Gln Ala Val Asn Asp Ser Cys Tyr Gln Asn Asp Asp Ser Val Leu Lys 
                245                 250                 255     


Ser Leu Val Glu Ile Ala Asp Thr Val Pro Lys Tyr Leu Arg Pro His 
            260                 265                 270         


Leu Glu Ala Thr Leu Gln Leu Ser Leu Lys Leu Cys Gly Asp Thr Ser 
        275                 280                 285             


Leu Asn Asn Met Gln Arg Gln Leu Ala Leu Glu Val Ile Val Thr Leu 
    290                 295                 300                 


Ser Glu Thr Ala Ala Ala Met Leu Arg Lys His Thr Asn Ile Val Ala 
305                 310                 315                 320 


Gln Thr Ile Pro Gln Met Leu Ala Met Met Val Asp Leu Glu Glu Asp 
                325                 330                 335     


Glu Asp Trp Ala Asn Ala Asp Glu Leu Glu Asp Asp Asp Phe Asp Ser 
            340                 345                 350         


Asn Ala Val Ala Gly Glu Ser Ala Leu Asp Arg Met Ala Cys Gly Leu 
        355                 360                 365             


Gly Gly Lys Leu Val Leu Pro Met Ile Lys Glu His Ile Met Gln Met 
    370                 375                 380                 


Leu Gln Asn Pro Asp Trp Lys Tyr Arg His Ala Gly Leu Met Ala Leu 
385                 390                 395                 400 


Ser Ala Ile Gly Glu Gly Cys His Gln Gln Met Glu Gly Ile Leu Asn 
                405                 410                 415     


Glu Ile Val Asn Phe Val Leu Leu Phe Leu Gln Asp Pro His Pro Arg 
            420                 425                 430         


Val Arg Tyr Ala Ala Cys Asn Ala Val Gly Gln Met Ala Thr Asp Phe 
        435                 440                 445             


Ala Pro Gly Phe Gln Lys Lys Phe His Glu Lys Val Ile Ala Ala Leu 
    450                 455                 460                 


Leu Gln Thr Met Glu Asp Gln Gly Asn Gln Arg Val Gln Ala His Ala 
465                 470                 475                 480 


Ala Ala Ala Leu Ile Asn Phe Thr Glu Asp Cys Pro Lys Ser Leu Leu 
                485                 490                 495     


Ile Pro Tyr Leu Asp Asn Leu Val Lys His Leu His Ser Ile Met Val 
            500                 505                 510         


Leu Lys Leu Gln Glu Leu Ile Gln Lys Gly Thr Lys Leu Val Leu Glu 
        515                 520                 525             


Gln Val Val Thr Ser Ile Ala Ser Val Ala Asp Thr Ala Glu Glu Lys 
    530                 535                 540                 


Phe Val Pro Tyr Tyr Asp Leu Phe Met Pro Ser Leu Lys His Ile Val 
545                 550                 555                 560 


Glu Asn Ala Val Gln Lys Glu Leu Arg Leu Leu Arg Gly Lys Thr Ile 
                565                 570                 575     


Glu Cys Ile Ser Leu Ile Gly Leu Ala Val Gly Lys Glu Lys Phe Met 
            580                 585                 590         


Gln Asp Ala Ser Asp Val Met Gln Leu Leu Leu Lys Thr Gln Thr Asp 
        595                 600                 605             


Phe Asn Asp Met Glu Asp Asp Asp Pro Gln Ile Ser Tyr Met Ile Ser 
    610                 615                 620                 


Ala Trp Ala Arg Met Cys Lys Ile Leu Gly Lys Glu Phe Gln Gln Tyr 
625                 630                 635                 640 


Leu Pro Val Val Met Gly Pro Leu Met Lys Thr Ala Ser Ile Lys Pro 
                645                 650                 655     


Glu Val Ala Leu Leu Asp Thr Gln Asp Met Glu Asn Met Ser Asp Asp 
            660                 665                 670         


Asp Gly Trp Glu Phe Val Asn Leu Gly Asp Gln Gln Ser Phe Gly Ile 
        675                 680                 685             


Lys Thr Ala Gly Leu Glu Glu Lys Ser Thr Ala Cys Gln Met Leu Val 
    690                 695                 700                 


Cys Tyr Ala Lys Glu Leu Lys Glu Gly Phe Val Glu Tyr Thr Glu Gln 
705                 710                 715                 720 


Val Val Lys Leu Met Val Pro Leu Leu Lys Phe Tyr Phe His Asp Gly 
                725                 730                 735     


Val Arg Val Ala Ala Ala Glu Ser Met Pro Leu Leu Leu Glu Cys Ala 
            740                 745                 750         


Arg Val Arg Gly Pro Glu Tyr Leu Thr Gln Met Trp His Phe Met Cys 
        755                 760                 765             


Asp Ala Leu Ile Lys Ala Ile Gly Thr Glu Pro Asp Ser Asp Val Leu 
    770                 775                 780                 


Ser Glu Ile Met His Ser Phe Ala Lys Cys Ile Glu Val Met Gly Asp 
785                 790                 795                 800 


Gly Cys Leu Asn Asn Glu His Phe Glu Glu Leu Gly Gly Ile Leu Lys 
                805                 810                 815     


Ala Lys Leu Glu Glu His Phe Lys Asn Gln Glu Leu Arg Gln Val Lys 
            820                 825                 830         


Arg Gln Asp Glu Asp Tyr Asp Glu Gln Val Glu Glu Ser Leu Gln Asp 
        835                 840                 845             


Glu Asp Asp Asn Asp Val Tyr Ile Leu Thr Lys Val Ser Asp Ile Leu 
    850                 855                 860                 


His Ser Ile Phe Ser Ser Tyr Lys Glu Lys Val Leu Pro Trp Phe Glu 
865                 870                 875                 880 


Gln Leu Leu Pro Leu Ile Val Asn Leu Ile Cys Pro His Arg Pro Trp 
                885                 890                 895     


Pro Asp Arg Gln Trp Gly Leu Cys Ile Phe Asp Asp Val Ile Glu His 
            900                 905                 910         


Cys Ser Pro Ala Ser Phe Lys Tyr Ala Glu Tyr Phe Leu Arg Pro Met 
        915                 920                 925             


Leu Gln Tyr Val Cys Asp Asn Ser Pro Glu Val Arg Gln Ala Ala Ala 
    930                 935                 940                 


Tyr Gly Leu Gly Val Met Ala Gln Tyr Gly Gly Asp Asn Tyr Arg Pro 
945                 950                 955                 960 


Phe Cys Thr Glu Ala Leu Pro Leu Leu Val Arg Val Ile Gln Ser Ala 
                965                 970                 975     


Asp Ser Lys Thr Lys Glu Asn Val Asn Ala Thr Glu Asn Cys Ile Ser 
            980                 985                 990         


Ala Val Gly Lys Ile Met Lys Phe  Lys Pro Asp Cys Val  Asn Val Glu 
        995                 1000                 1005             


Glu Val  Leu Pro His Trp Leu  Ser Trp Leu Pro Leu  His Glu Asp 
    1010                 1015                 1020             


Lys Glu  Glu Ala Val Gln Thr  Phe Asn Tyr Leu Cys  Asp Leu Ile 
    1025                 1030                 1035             


Glu Ser  Asn His Pro Ile Val  Leu Gly Pro Asn Asn  Thr Asn Leu 
    1040                 1045                 1050             


Pro Lys  Ile Phe Ser Ile Ile  Ala Glu Gly Glu Met  His Glu Ala 
    1055                 1060                 1065             


Ile Lys  His Glu Asp Pro Cys  Ala Lys Arg Leu Ala  Asn Val Val 
    1070                 1075                 1080             


Arg Gln  Val Gln Thr Ser Gly  Gly Leu Trp Thr Glu  Cys Ile Ala 
    1085                 1090                 1095             


Gln Leu  Ser Pro Glu Gln Gln  Ala Ala Ile Gln Glu  Leu Leu Asn 
    1100                 1105                 1110             


Ser Ala  
    1115 


<210>  3140
<211>  4335
<212>  DNA
<213>  Homosapiens

<400>  3140
gcgcggagct gggagtggct tcgccatggc tgtgagaagg gactccgtgt ggaagtactg     60

ctggggtgtt ttgatggttt tatgcagaac tgcgatttcc aaatcgatag ttttagagcc    120

tatctattgg aattcctcga actccaaatt tctacctgga caaggactgg tactataccc    180

acagatagga gacaaattgg atattatttg ccccaaagtg gactctaaaa ctgttggcca    240

gtatgaatat tataaagttt atatggttga taaagaccaa gcagacagat gcactattaa    300

gaaggaaaat acccctctcc tcaactgtgc caaaccagac caagatatca aattcaccat    360

caagtttcaa gaattcagcc ctaacctctg gggtctagaa tttcagaaga acaaagatta    420

ttacattata tctacatcaa atgggtcttt ggagggcctg gataaccagg agggaggggt    480

gtgccagaca agagccatga agatcctcat gaaagttgga caagatgcaa gttctgctgg    540

atcaaccagg aataaagatc caacaagacg tccagaacta gaagctggta caaatggaag    600

aagttcgaca acaagtccct ttgtaaaacc aaatccaggt tctagcacag acggcaacag    660

cgccggacat tcggggaaca acatcctcgg ttccgaagtg gccttatttg cagggattgc    720

ttcaggatgc atcatcttca tcgtcatcat catcacgctg gtggtcctct tgctgaagta    780

ccggaggaga cacaggaagc actcgccgca gcacacgacc acgctgtcgc tcagcacact    840

ggccacaccc aagcgcagcg gcaacaacaa cggctcagag cccagtgaca ttatcatccc    900

gctaaggact gcggacagcg tcttctgccc tcactacgag aaggtcagcg gggactacgg    960

gcacccggtg tacatcgtcc aggagatgcc cccgcagagc ccggcgaaca tttactacaa   1020

ggtctgagag ggaccctggt ggtacctgtg ctttcccaga ggacacctaa tgtcccgatg   1080

cctcccttga gggtttgaga gcccgcgtgc tggagaattg actgaagcac agcaccgggg   1140

gagagggaca ctcctcctcg gaagagcccg tcgcgctgga cagcttacct agtcttgtag   1200

cattcggcct tggtgaacac acacgctccc tggaagctgg aagactgtgc agaagacgcc   1260

cattcggact gctgtgccgc gtcccacgtc tcctcctcga agccatgtgc tgcggtcact   1320

caggcctctg cagaagccaa gggaagacag tggtttgtgg acgagagggc tgtgagcatc   1380

ctggcaggtg ccccaggatg ccacgcctgg aagggccggc ttctgcctgg ggtgcatttc   1440

ccccgcagtg cataccggac ttgtcacacg gacctcgggc tagttaaggt gtgcaaagat   1500

ctctagagtt tagtccttac tgtctcactc gttctgttac ccagggctct gcagcacctc   1560

acctgagacc tccactccac atctgcatca ctcatggaac actcatgtct ggagtcccct   1620

cctccagccg ctggcaacaa cagcttcagt ccatgggtaa tccgttcata gaaattgtgt   1680

ttgctaacaa ggtgcccttt agccagatgc taggctgtct gcgaagaagg ctaggagttc   1740

atagaaggga gtggggctgg ggaaagggct ggctgcaatt gcagctcact gctgctgcct   1800

ctgaaacaga aagttggaaa ggaaaaaaga aaaaagcaat taggtagcac agcactttgg   1860

ttttgctgag atcgaagagg ccagtaggag acacgacagc acacacagtg gattccagtg   1920

catggggagg cactcgctgt tatcaaatag cgatgtgcag gaagaaaagc ccctcttcat   1980

tccggggaac aaagacgggt attgttggga aaggaacagg cttggaggga agggagaaag   2040

taggccgctg atgatatatt cgggcaggac tgttgtggta ctggcaataa gatacacagc   2100

tccgagctgt aggagagtcg gtctgctttg gatgattttt taagcagact cagctgctat   2160

acttatcaca ttttattaaa cacagggaaa gcatttagga gaatagcaga gagccaaatc   2220

tgacctaaaa gttgaaaagc caaaggtcaa acaggctgta attccatcat catcgttgtt   2280

attaaagaat ccttatctat aaaaggtagg tcagatcccc ctccccccag gttcctcctt   2340

cccctcccga ttgagcctta cgacactttg gtttatgcgg tgctgtccgg gtgccagggc   2400

tgcagggtcg gtactgatgg aggctgcagc gcccggtgct ctgtgtcaag gtgaagcaca   2460

tacggcagac ctcttagagt ccttaagacg gaagtaaatt atgatgtcca gggggagaag   2520

gaagatagga cgtatttata ataggtatat agaacacaag ggatataaaa tgaaagattt   2580

ttactaatat atattttaag gttgcacaca gtacacacca gaagatgtga aattcatttg   2640

tggcaattaa gtggtcccaa tgctcagcgc ttaaaaaaac aaattggaca gctacttctg   2700

ggaaaaacaa catcattcca aaaagaacaa taatgagagc aaatgcaaaa ataaccaagt   2760

cctccgaagg catctcacgg aaccgtagac taggaagtac gagccccaca gagcaggaag   2820

ccgatgtgac tgcatcatat atttaacaat gacaagatgt tccggcgttt atttctgcgt   2880

tgggttttcc cttgccttat gggctgaagt gttctctaga atccagcagg tcacactggg   2940

ggcttcaggt gacgatttag ctgtggctcc ctcctcctgt cctcccccgc accccctccc   3000

ttctgggaaa caagaagagt aaacaggaaa cctacttttt atgtgctatg caaaatagac   3060

atctttaaca tagtcctgtt actatggtaa cactttgctt tctgaattgg aagggaaaaa   3120

aaatgtagcg acagcatttt aaggttctca gacctccagt gagtacctgc aaaaatgagt   3180

tgtcacagaa attatgatcc tctatttcct gaacctggaa atgatgttgg tccaaagtgc   3240

gtgtgtgtat gtgtgagtgg gtgcgtggta tacatgtgta catatatgta taatatatat   3300

ctacaatata tattatatat atctatatca tatttctgtg gagggttgcc atggtaacca   3360

gccacagtac atatgtaatt ctttccatca ccccaacctc tcctttctgt gcattcatgc   3420

aagagtttct tgtaagccat cagaagttac ttttaggatg ggggagaggg gcgagaaggg   3480

gaaaaatggg aaatagtctg attttaatga aatcaaatgt atgtatcatc agttggctac   3540

gttttggttc tatgctaaac tgtgaaaaat cagatgaatt gataaaagag ttccctgcaa   3600

ccaattgaaa agtgttctgt gcgtctgttt tgtgtctggt gcagaatatg acaatctacc   3660

aactgtccct ttgtttgaag ttggtttagc tttggaaagt tactgtaaat gccttgcttg   3720

tatgatcgtc cctggtcacc cgactttgga atttgcacca tcatgtttca gtgaagatgc   3780

tgtaaatagg ttcagatttt actgtctatg gatttggggt gttacagtag ccttattcac   3840

ctttttaata aaaatacaca tgaaaacaag aaagaaatgg cttttcttac ccagattgtg   3900

tacatagagc aatgttggtt ttttataaag tctaagcaag atgttttgta taaaatctga   3960

attttgcaat gtatttagct acagcttgtt taacggcagt gtcattcccc tttgcactgt   4020

aatgaggaaa aaatggtata aaaggttgcc aaattgctgc atatttgtgc cgtaattatg   4080

taccatgaat atttatttaa aatttcgttg tccaatttgt aagtaacaca gtattatgcc   4140

tgagttataa atattttttt ctttctttgt tttattttaa tagcctgtca taggttttaa   4200

atctgcttta gtttcacatt gcagttagcc ccagaaaatg aaatccgtga agtcacattc   4260

cacatctgtt tcaaactgaa tttgttctta aaaaaataaa atattttttt cctatggaaa   4320

aaaaaaaaaa aaaaa                                                    4335


<210>  3141
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  3141

Met Ala Val Arg Arg Asp Ser Val Trp Lys Tyr Cys Trp Gly Val Leu 
1               5                   10                  15      


Met Val Leu Cys Arg Thr Ala Ile Ser Lys Ser Ile Val Leu Glu Pro 
            20                  25                  30          


Ile Tyr Trp Asn Ser Ser Asn Ser Lys Phe Leu Pro Gly Gln Gly Leu 
        35                  40                  45              


Val Leu Tyr Pro Gln Ile Gly Asp Lys Leu Asp Ile Ile Cys Pro Lys 
    50                  55                  60                  


Val Asp Ser Lys Thr Val Gly Gln Tyr Glu Tyr Tyr Lys Val Tyr Met 
65                  70                  75                  80  


Val Asp Lys Asp Gln Ala Asp Arg Cys Thr Ile Lys Lys Glu Asn Thr 
                85                  90                  95      


Pro Leu Leu Asn Cys Ala Lys Pro Asp Gln Asp Ile Lys Phe Thr Ile 
            100                 105                 110         


Lys Phe Gln Glu Phe Ser Pro Asn Leu Trp Gly Leu Glu Phe Gln Lys 
        115                 120                 125             


Asn Lys Asp Tyr Tyr Ile Ile Ser Thr Ser Asn Gly Ser Leu Glu Gly 
    130                 135                 140                 


Leu Asp Asn Gln Glu Gly Gly Val Cys Gln Thr Arg Ala Met Lys Ile 
145                 150                 155                 160 


Leu Met Lys Val Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn 
                165                 170                 175     


Lys Asp Pro Thr Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg 
            180                 185                 190         


Ser Ser Thr Thr Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr 
        195                 200                 205             


Asp Gly Asn Ser Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu 
    210                 215                 220                 


Val Ala Leu Phe Ala Gly Ile Ala Ser Gly Cys Ile Ile Phe Ile Val 
225                 230                 235                 240 


Ile Ile Ile Thr Leu Val Val Leu Leu Leu Lys Tyr Arg Arg Arg His 
                245                 250                 255     


Arg Lys His Ser Pro Gln His Thr Thr Thr Leu Ser Leu Ser Thr Leu 
            260                 265                 270         


Ala Thr Pro Lys Arg Ser Gly Asn Asn Asn Gly Ser Glu Pro Ser Asp 
        275                 280                 285             


Ile Ile Ile Pro Leu Arg Thr Ala Asp Ser Val Phe Cys Pro His Tyr 
    290                 295                 300                 


Glu Lys Val Ser Gly Asp Tyr Gly His Pro Val Tyr Ile Val Gln Glu 
305                 310                 315                 320 


Met Pro Pro Gln Ser Pro Ala Asn Ile Tyr Tyr Lys Val 
                325                 330             


<210>  3142
<211>  4024
<212>  DNA
<213>  Homosapiens

<400>  3142
gcggctgcca tcttaggggc gcctggcgct acgggtttct cgttggaggc ggccttcgtg     60

gcagctgtag acgccgggaa aaggcataaa gtccgttggc cgacaccttt ctttcctccg    120

gcctcggtag aaccgccagc ccgcgtccga aggcggaggc gaggggaact ggccgcgtga    180

ggggcctgag gcgagcggtt agagcgtctc ccggaaggat gggccggtct cggagccgga    240

gctcgtcccg ctccaagcac accaagagca gcaagcacaa caagaagcgc agccggtccc    300

ggtcgcgatc ccgggacaag gagcgcgtgc ggaagcgttc caaatctcgg gaaagtaaac    360

ggaaccggcg gcgggagtcg cggtcccgtt cgcgctccac caacacggcc gtgtcccggc    420

gcgagcggga ccgggagcgc gcctcgtccc cgcccgaccg catcgacatc ttcgggcgca    480

cggtgagcaa gcgcagcagc ctggacgaga agcagaagcg agaggaggag gagaagaaag    540

cggagttcga gcggcagcga aaaattcgac agcaagaaat agaagaaaaa ctcatcgagg    600

aagaaacagc acgaagagta gaagaattgg tagcaaaaag ggtggaggaa gaactggaga    660

aaaggaagga tgaaattgaa cgagaagttc tccgaagggt ggaggaagcc aaacgcatca    720

tggaaaagca gttgctcgaa gaactcgagc gacagagaca agctgagctt gccgcacaaa    780

aagctagaga ggtaacgctc ggtcgtttgg aaagtagaga cagtccatgg caaaactttc    840

agtgttgggt tctgcctcct gctcagttca gaaagagatg gaatacagac tatctaattc    900

ctttctcgtc taaacttaac attgctgcga aagttaattt tttagcctat tcagaggtgc    960

tgactgataa cttaaaagtt ggaagctttt ataaaacata ttcaaggata ctttttgatt   1020

taatggaact ggctatttga gaagtgtttg aaacttttgc catggctgca ggacttacat   1080

tcttttttgg gaggacggtg gggagacagg gagtggtaaa gggaaaaggt taaaaatcca   1140

cctgtggttg tatattcttc tattctgtca ctctgttacc tagactgtga gaggcttttg   1200

ccttcagtca gattaaaaag agcagggcct aacattgagt gatagcacct gctttgataa   1260

ataggttttc tcactcttct ttttttcctt cttttatccc tcactccctc ccctaaaccc   1320

tgcttcagca caatggacta attctagcat tctgatcata aggccctcca ttttcctaat   1380

gtgtttcaag gaatcttttt aggaaaaata tccagattat tcatccactt tttttagtat   1440

ctactaacaa ctcctttttt tctctagaga gttatgaagg aacaggttgt ccttgtctgg   1500

agtcaagcta aacacatgat ttgttttatc agcagctgga gcagaagttg aaaatgtctt   1560

tctgtgagac agtaatttgc tactgaagct ttatggcttg tttgcactga ttactccagg   1620

atccaaaaac ttggtgaaag tcactgaaac actcaaggca aattacttta cagccctgag   1680

tgtctgtcac catagtttgc ataatgaata tgaatcccat tggtgtgtgg tgtaggaaat   1740

cctgtagttg tattttcttg aactgaaata tttgactcaa aataattaag actcattgtc   1800

atttttcatc ttggcattat tgtggacaag ttgacatatt aaatctcttt gctttctggt   1860

aagcttagct tttaaaatgc attttccctt gtcctgtctt taactagata tacatgctta   1920

tatttatagt gggtttcaca gactataaaa ttgaatgtat gaaattttta tttatatcag   1980

tgcttttaat aatgaagata tttttggagt aatggtgctg tcttgtagcg agttattaat   2040

catagtaaga tttttttctc ttcatttgct ttttttgttt catattaaca attttttttt   2100

tacacggaca caaccctctg acagtctttc caaatattaa aatcatttga atatgtatgc   2160

tgtgatctga acactgctca agccatcaag cagtcttcat acagtttgca ttataaaatc   2220

tcattaaatt ctccaagaaa aaataagttg aagaatttta tttcctgacc atgcatcccc   2280

tggatttctg agtttcagtt cagattgtag atgacaatat aagctgcctt ccgaaattgt   2340

caacatctga atgttaagtc cattttcccc atggaagaag cccgtagttc catgaagtat   2400

ggattaccat ttgtattttt cactaacagt aaatgtattt ttcttattaa ttgtttgcct   2460

taggaatgat gaattacatt ttttgttcct tcttaccata aacatctgca ttgctcagct   2520

cagccttcct tgtatgttgt ttctttataa atggttgagc tgctgatgca ggtattgcca   2580

agctaacagt acaaatcatt ttaaagagga agctggcgcg tatggcagcc gaggagcaca   2640

ctctgcagga cactggacaa gacagtaaat attcaacttt taatgctgat taaaggagta   2700

taggtaaaga atacgtaggt atacataatt ggtgagacaa atattcactt tatttatatt   2760

ttatatatta tttttttaat ttggtaaata ctatccagtt ttgtagttgt ccttgttgat   2820

ttgtgtgata ttaaagtatt agtaataatt gccaggaaac tatcattagg gagggtttag   2880

ttggttgctg tttggactgg gagggatgat ttaaatttag tgctagaaac caattttagt   2940

gactgcacag tttatcattt gtcagacaga aggtagctat aaagctaccc tgtaagtcat   3000

atcaaaaaag ttcagaggaa gattagtaaa tatttatcaa taaaaataaa cattttgttt   3060

ttctaatatc ttaacatatc ctccccttta ggaggaagaa cgtgcaaaac gtgaggagct   3120

agagcgaata ctggaagaga ataaccgaaa aattgcagaa gcacaagcca aactggccga   3180

agaacagttg agaattgttg aagaacaaag aaagattcat gaggaaagga tgaaactaga   3240

acaagaacga caacgtcaac aaaaagaaga acaaaaaatt atcctgggca aggggaagtc   3300

caggccaaaa ctgtccttct cattaaaaac ccaggattaa attgcaaact ctgaactttt   3360

tacaaagaaa aatggaaaaa ctttgtatgg tagcttcatg ttgaagtggt tttttgtttt   3420

tgtttttgtt tttttaattt gtaaaatctg gaaagttagc ttgttctaat aggggctatg   3480

ctctgcaatt cccttttttt tttttttttt ccttccacta agtcaaatcc ttatcagatc   3540

attgttgtat tctaaggagt gacgtatttt tcacctgttt ggattctata ttagtggtct   3600

gaggaagagc agatcacatt gtaaaactat ggatggtctg ataaggcttt tactgacccc   3660

actgacttca gagttatact ctgtttgcta catcataatg ctggttttgc tgactttttg   3720

tttttttata tatttataaa aaaagaaaaa gttggtgatt gcattgggaa attcccaggg   3780

tattactgga cctatgtggt gtattgttaa accagtgtcc ttgtgatact gttgctcttg   3840

atgttcctga tacaggtaag gaaacagttg gtcaactctg atacaaagta tatatacagt   3900

tcagtattgt ctctgttcat tttgttttta tttcattgac aaaatcaaac cagcattccc   3960

cattgtgtaa ataaatgatt ttgctgaata aagtaaagtc ttaaattcaa aaaaaaaaaa   4020

aaaa                                                                4024


<210>  3143
<211>  273
<212>  PRT
<213>  Homosapiens

<400>  3143

Met Gly Arg Ser Arg Ser Arg Ser Ser Ser Arg Ser Lys His Thr Lys 
1               5                   10                  15      


Ser Ser Lys His Asn Lys Lys Arg Ser Arg Ser Arg Ser Arg Ser Arg 
            20                  25                  30          


Asp Lys Glu Arg Val Arg Lys Arg Ser Lys Ser Arg Glu Ser Lys Arg 
        35                  40                  45              


Asn Arg Arg Arg Glu Ser Arg Ser Arg Ser Arg Ser Thr Asn Thr Ala 
    50                  55                  60                  


Val Ser Arg Arg Glu Arg Asp Arg Glu Arg Ala Ser Ser Pro Pro Asp 
65                  70                  75                  80  


Arg Ile Asp Ile Phe Gly Arg Thr Val Ser Lys Arg Ser Ser Leu Asp 
                85                  90                  95      


Glu Lys Gln Lys Arg Glu Glu Glu Glu Lys Lys Ala Glu Phe Glu Arg 
            100                 105                 110         


Gln Arg Lys Ile Arg Gln Gln Glu Ile Glu Glu Lys Leu Ile Glu Glu 
        115                 120                 125             


Glu Thr Ala Arg Arg Val Glu Glu Leu Val Ala Lys Arg Val Glu Glu 
    130                 135                 140                 


Glu Leu Glu Lys Arg Lys Asp Glu Ile Glu Arg Glu Val Leu Arg Arg 
145                 150                 155                 160 


Val Glu Glu Ala Lys Arg Ile Met Glu Lys Gln Leu Leu Glu Glu Leu 
                165                 170                 175     


Glu Arg Gln Arg Gln Ala Glu Leu Ala Ala Gln Lys Ala Arg Glu Val 
            180                 185                 190         


Thr Leu Gly Arg Leu Glu Ser Arg Asp Ser Pro Trp Gln Asn Phe Gln 
        195                 200                 205             


Cys Trp Val Leu Pro Pro Ala Gln Phe Arg Lys Arg Trp Asn Thr Asp 
    210                 215                 220                 


Tyr Leu Ile Pro Phe Ser Ser Lys Leu Asn Ile Ala Ala Lys Val Asn 
225                 230                 235                 240 


Phe Leu Ala Tyr Ser Glu Val Leu Thr Asp Asn Leu Lys Val Gly Ser 
                245                 250                 255     


Phe Tyr Lys Thr Tyr Ser Arg Ile Leu Phe Asp Leu Met Glu Leu Ala 
            260                 265                 270         


Ile 
    


<210>  3144
<211>  1926
<212>  DNA
<213>  Homosapiens

<400>  3144
tggggggttt atcatcagaa ggagagagac ccgagggagc cacctgccca ctccagatga     60

ggtgctccgt ggaacacgag gagcacacga aacccgatca gctttgtgtg acttccgcgt    120

gtggggtggc acgcgtgtgc ttgctattca ttgtttctgc tgggggcatt tttatctttt    180

gaaattcttt cttctgaacc tttcgtgcct accagaacca gcctgtcagg atgcgcctga    240

tctccacagc agcccctcca tccgactctg aagaagccgt cagctcacag aagattcctt    300

ttgtttaatg agtaacagct actgactcac tccatggccc accagaatga cagactcctg    360

ttcaaaagcc tgatctgaag ttgctgccat gacacaagca atgcctgtga agtgcctgca    420

gcccacgcct ctgagacagg ccaggcgtgt ggtggacacg cagctgcagg cgcttgctct    480

ctgtcatcac gagaaaaagt atccctgcac cggacaagaa aggacctgca ggcacactca    540

caatcaactt cctgatttca caatgatggt agggagccct gtgggcacta gaagcagcgg    600

ggaggggttc tagacctttg gtgcccaaga gacttccgtg catggaaaat gttgacttct    660

agcttccatc tgcagcgaac tctccatcgg gacatgggac ctggctgtac gagttaattc    720

aaactgagcc actttccatt agggcaccaa atggagttag caatccaaga ttattttatt    780

ttctgggcta tccagatgac ttaaagcctc gctgaagttc ccatgagaag agtttaaaca    840

acccaaagaa agcacatcat ggtcgactgc agggaactga aactacagaa atgaacactt    900

ccaataagag gcaactactg ttctcaaacg gccctaaaag gcaccgagac tttcaccttg    960

tcacgaagat gcccagggag cccacggaga ggtcaacatg gcaagcactg gaggtggaag   1020

gggtcatggg ggtctggtcc tcctgccaca gtcaagcttt cagatgatgc agcctgctga   1080

cattgtgact gaaggacacc aagctggaac tacccatcta ggcctctctg gactcttggc   1140

ccacagaagc caggtgaagc agaatcagag aaggcttgaa gctcagcctc cccaagctac   1200

gaatgcatga ttgcaccagc gcaagacagg aatccccagt cccggctgca ggggccaggg   1260

cagcttggac tctccacggc tcttcagctt ggctttctgg gcatttcaag acaggtcatg   1320

gaaggtccac tgggagccga ggatgctgtt cttgcagtaa aggtctcagc ttctgctatg   1380

ccagtcaatc ggggtgaagg aagtgacttt tcttcagatg gagaggccaa gaattttatg   1440

cagatagcaa caaggtccct gacacaggga agcaatatcc ctgcacagac cagcttaaga   1500

caagattagt gtggagcaca ggaggatcaa gaggatctgc acggggtgag ataaggaatc   1560

tggacagacc agaaaagagg cgattcccca gacacccagt gagaagtgac atttgggaga   1620

tgaggatggg ccatttacat acatcatgaa tgggaatgcc tgtattgttc atgtaactcg   1680

cagggaaaat gtcagaaaat tcatccaaat ctacattgta cacttgatga ggcagccgat   1740

tggctgagag gcttgggaaa atcagccggg tctacccaga gcttacgtag ctcagattgc   1800

gggcacatgg ctgtggggca ccctaattcc tgagggtccc cccaacatgg gctggcaagg   1860

cggggattgc aaaagtctcc agttaccagc accctgaaca tgcacccttt gattaaatca   1920

ccccac                                                              1926


<210>  3145
<211>  100
<212>  PRT
<213>  Homosapiens

<400>  3145

Met Ile Ala Pro Ala Gln Asp Arg Asn Pro Gln Ser Arg Leu Gln Gly 
1               5                   10                  15      


Pro Gly Gln Leu Gly Leu Ser Thr Ala Leu Gln Leu Gly Phe Leu Gly 
            20                  25                  30          


Ile Ser Arg Gln Val Met Glu Gly Pro Leu Gly Ala Glu Asp Ala Val 
        35                  40                  45              


Leu Ala Val Lys Val Ser Ala Ser Ala Met Pro Val Asn Arg Gly Glu 
    50                  55                  60                  


Gly Ser Asp Phe Ser Ser Asp Gly Glu Ala Lys Asn Phe Met Gln Ile 
65                  70                  75                  80  


Ala Thr Arg Ser Leu Thr Gln Gly Ser Asn Ile Pro Ala Gln Thr Ser 
                85                  90                  95      


Leu Arg Gln Asp 
            100 


<210>  3146
<211>  774
<212>  DNA
<213>  Homosapiens

<400>  3146
agaacatcct tctccctcag ctggagggag catggcagtg agccaaggag acgggaccct     60

ctgctttgtc ctcctgctgt gctgttggca agaaactgag ctccggccga gaaccgtgat    120

tccaggttca cctactgaaa taccattcag ttcaaaacag gaggatatgt ctgaattatt    180

agatgaaatt ctggtccagg agattttgga tctgaataaa acaacaccga gcgaaatgcc    240

aagtacagca tcaacattat caacaccgtt acatgctggt attgatgaga attatcaagc    300

tggtggttct gagaattacc atgaattatt agagaattta caattctctc ctggcattga    360

ggacaaaatt tccaatgatg aagccaatgc taatgcaaat ctccatggcg atccttctga    420

gaattatcgt gggccacagg tgtctcctgg cagtgagaag agtgtttcca gtaaagaaaa    480

gaattcaaag aacactcagt atgaaaatct atccattctg gaccaaatcc ttcaaaatat    540

tggaagatct tcaggaaaca ttttccataa agagcagcag aggaccagcg cacagaggag    600

gagccaaggc agtcagtgag gccgcagccc cagaccccct gcgcaggaga ggagcctgct    660

agaaccccca cccaccagcc tccggaacag ggcacttgtg tgcacacgcc cacgttctct    720

gaaccattcc acataaagga aaatcgttta ttcacaccaa aaaaaaaaaa aaaa          774


<210>  3147
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  3147

Met Ala Val Ser Gln Gly Asp Gly Thr Leu Cys Phe Val Leu Leu Leu 
1               5                   10                  15      


Cys Cys Trp Gln Glu Thr Glu Leu Arg Pro Arg Thr Val Ile Pro Gly 
            20                  25                  30          


Ser Pro Thr Glu Ile Pro Phe Ser Ser Lys Gln Glu Asp Met Ser Glu 
        35                  40                  45              


Leu Leu Asp Glu Ile Leu Val Gln Glu Ile Leu Asp Leu Asn Lys Thr 
    50                  55                  60                  


Thr Pro Ser Glu Met Pro Ser Thr Ala Ser Thr Leu Ser Thr Pro Leu 
65                  70                  75                  80  


His Ala Gly Ile Asp Glu Asn Tyr Gln Ala Gly Gly Ser Glu Asn Tyr 
                85                  90                  95      


His Glu Leu Leu Glu Asn Leu Gln Phe Ser Pro Gly Ile Glu Asp Lys 
            100                 105                 110         


Ile Ser Asn Asp Glu Ala Asn Ala Asn Ala Asn Leu His Gly Asp Pro 
        115                 120                 125             


Ser Glu Asn Tyr Arg Gly Pro Gln Val Ser Pro Gly Ser Glu Lys Ser 
    130                 135                 140                 


Val Ser Ser Lys Glu Lys Asn Ser Lys Asn Thr Gln Tyr Glu Asn Leu 
145                 150                 155                 160 


Ser Ile Leu Asp Gln Ile Leu Gln Asn Ile Gly Arg Ser Ser Gly Asn 
                165                 170                 175     


Ile Phe His Lys Glu Gln Gln Arg Thr Ser Ala Gln Arg Arg Ser Gln 
            180                 185                 190         


Gly Ser Gln 
        195 


<210>  3148
<211>  3909
<212>  DNA
<213>  Homosapiens

<400>  3148
gtgtgggaag cgcccgcgct ttcggcgggt tccgttaaaa tggcgccctg gtggccggcg     60

gcgcccgcgc cttagcctgt caggagcagg gagcttgcgg ggcgcaggaa gggcgcgggc    120

cgcggtccct gcgcgtgcgg cggcagtggc ggctctgccc ggaccaccgt gcacggctcc    180

gggcgaggat ggcgaccccg gaccagaagt cgccgaacgt tctgctgcag aacctgtgct    240

gcaggatcct gggcaggagc gaagctgatg tagcccagca gttccagtat gctgtgcggg    300

tgattggcag caacttcgcc ccaactgttg aaagagatga atttttagta gctgaaaaaa    360

tcaagaaaga gcttattcga caacgaagag aagcagatgc tgcattattt tcagaactcc    420

acagaaaact tcattcacag ggagttttga aaaataaatg gtcaatactc tacctcttgc    480

tgagcctcag tgaggaccca cgcaggcagc caagcaaggt ttctagctat gctacgttat    540

ttgctcaggc cttaccaaga gatgcccact caacccctta ctactatgcc aggcctcaga    600

cccttcccct gagctaccaa gatcggagtg cccagtcagc ccagagctcc ggcagcgtgg    660

gcagcagtgg catcagcagc attggcctgt gtgccctcag tggccccgcg cctgcgccac    720

aatctctcct cccaggacag tctaatcaag ctccaggagt aggagattgc cttcgacagc    780

agttggggtc acgactcgca tggactttaa ctgcaaatca gccttcttca caagccacta    840

cctcaaaagg tgtccccagt gctgtgtctc gcaacatgac aaggtccagg agagaagggg    900

atacgggtgg tactatggaa attacagaag cagctctggt aagggacatt ttgtacgtct    960

ttcagggcat agatggcaaa aacatcaaaa tgaacaacac tgaaaattgt tacaaagtag   1020

aaggaaaggc aaatctaagt aggtctttga gagacacagc agtcaggctt tctgagttgg   1080

gatggttgca taataaaatc agaagataca cggaccagag gagcctggac cgctcattcg   1140

gactcgtcgg gcagagcttt tgtgctgcct tgcaccagga actcagagaa tactatcgat   1200

tgctctctgt tttacattct cagctacaac tagaggatga ccagggtgtg aatttgggac   1260

ttgagagtag tttaacactt cggcgcctcc tggtttggac ctatgatccc aaaatacgac   1320

tgaagaccct tgcggcccta gtggaccact gccaaggaag gaaaggaggt gagctggcct   1380

cagctgtcca cgcctacaca aaaacaggag acccgtacat gcggtctctg gtgcagcaca   1440

tcctcagcct cgtgtctcat cctgttttga gcttcctgta ccgctggata tatgatgggg   1500

agcttgagga cacttaccac gaattttttg tagcatcaga tccaacagtt aaaacagatc   1560

gactgtggca cgacaagtat actttgagga aatcgatgat tccttcgttt atgacgatgg   1620

atcagtctag gaaggtcctt ttgataggaa aatcaataaa tttcttgcac caagtttgtc   1680

atgatcagac tcccactaca aagatgatag ctgtgaccaa gtctgcagag tcaccccagg   1740

acgctgcaga cctattcaca gacttggaaa atgcatttca ggggaagatt gatgctgctt   1800

attttgagac cagcaaatac ctgttggatg ttctcaataa aaagtacagc ttgctggacc   1860

acatgcaggc aatgaggcgg tacctgcttc ttggtcaagg agactttata aggcacttaa   1920

tggacttgct aaaaccagaa cttgtccgtc cagctacgac tttgtatcag cataacttga   1980

ctggaattct agaaaccgct gtcagagcca ccaacgcaca gtttgacagt cctgagatcc   2040

tgcgaaggct ggacgtgcgg ctgctggagg tctctccagg tgacactgga tgggatgtct   2100

tcagcctcga ttatcatgtt gacggaccaa ttgcaactgt gtttactcga gaatgtatga   2160

gccactacct aagagtattt aacttcctct ggagggcgaa gcggatggaa tacatcctca   2220

ctgacatacg gaagggacac atgtgcaatg caaagctcct gagaaacatg ccagagttct   2280

ccggggtgct gcaccagtgt cacattttgg cctctgagat ggtccatttc attcatcaga   2340

tgcagtatta catcacattt gaggtgcttg aatgttcttg ggatgagctt tggaacaaag   2400

tccagcaggc ccaggatttg gatcacatca ttgctgcaca cgaggtgttc ttagacacca   2460

tcatctcccg ctgcctgctg gacagtgact ccagggcact tttaaatcaa cttagagctg   2520

tgtttgatca aattattgaa cttcagaatg ctcaagatgc aatatacaga gctgctctgg   2580

aagaattgca gagacgatta cagtttgaag agaaaaagaa acagcgtgaa attgagggcc   2640

agtggggagt gacggcagca gaggaagagg aggaaaataa gaggattgga gaatttaaag   2700

aatctatacc aaaaatgtgc tcacagttgc gaatattgac ccatttctac cagggtatcg   2760

tgcagcagtt tttggtgtta ctgacgacca gctctgacga gagtcttcgg tttcttagct   2820

tcaggctgga cttcaacgag cattacaaag ccagggagcc caggctccgt gtgtctctgg   2880

gtaccagggg gcggcgcagc tcccacacgt gaagctcgcg gtcctcccag ggagctgcgg   2940

gtgatgttcg ttgcactgct agacacgaaa ttcccattga cgtcctgcag gaactgcatg   3000

ctgcaggtgt cctgcccttc cgcccacgag tgcgccatgt ttcagcggag cggcgtgtgg   3060

gagaagccac gtcgtgtttc acatgtcgga gtcgaatgca tttgtaaatc cctaagtcaa   3120

gtaggctggc tgcactgttc gcatttgtct ctaaaagtct tcatcgctaa aagataccat   3180

aatttgctga ggcttcttaa gctttctatg ttataattta tatttgtcac tttaaaaaat   3240

ccatttcttt tagaaaaaat tagggtgata ggatattcat tagttaagat ggtaacgtca   3300

ttgctatttt tttaacatcc tctttagagg taatttttgt taacataacc aaaaattaaa   3360

ttgaaacaaa atgtcccaac taagaaaata tatagagcat tttatttttt tttagtgttg   3420

taaaatatta acctctgtga gatcctttgt atcttaatgc attaccttta cacatattta   3480

ttcttatttt ctctcctttc agagtttaca tttttatatt taatttacta tttcagattt   3540

ttaaaatagt atagaaaaaa gtaggagtga tagagaacaa aaatactctt atacagtgca   3600

acccaaatac cgcgaatgca tcagctaaag cagcgtgtaa ataggagtga tgagaaagtt   3660

aatggagtat tttattttca aagttcctga taagcattgg aaagaaatcg acatggataa   3720

tgaagatttc ctttttcctt gcctattttt tcattgtaaa tatttatata ctactgacca   3780

agatgttggg gtggggggga ttgttttttg taaaaatgtc attatcaggt cacataaatc   3840

tgcctttatg ttgcataagt gaaaatttag aaaattaaaa gcaattatct tccaaaaaaa   3900

aaaaaaaaa                                                           3909


<210>  3149
<211>  907
<212>  PRT
<213>  Homosapiens

<400>  3149

Met Ala Thr Pro Asp Gln Lys Ser Pro Asn Val Leu Leu Gln Asn Leu 
1               5                   10                  15      


Cys Cys Arg Ile Leu Gly Arg Ser Glu Ala Asp Val Ala Gln Gln Phe 
            20                  25                  30          


Gln Tyr Ala Val Arg Val Ile Gly Ser Asn Phe Ala Pro Thr Val Glu 
        35                  40                  45              


Arg Asp Glu Phe Leu Val Ala Glu Lys Ile Lys Lys Glu Leu Ile Arg 
    50                  55                  60                  


Gln Arg Arg Glu Ala Asp Ala Ala Leu Phe Ser Glu Leu His Arg Lys 
65                  70                  75                  80  


Leu His Ser Gln Gly Val Leu Lys Asn Lys Trp Ser Ile Leu Tyr Leu 
                85                  90                  95      


Leu Leu Ser Leu Ser Glu Asp Pro Arg Arg Gln Pro Ser Lys Val Ser 
            100                 105                 110         


Ser Tyr Ala Thr Leu Phe Ala Gln Ala Leu Pro Arg Asp Ala His Ser 
        115                 120                 125             


Thr Pro Tyr Tyr Tyr Ala Arg Pro Gln Thr Leu Pro Leu Ser Tyr Gln 
    130                 135                 140                 


Asp Arg Ser Ala Gln Ser Ala Gln Ser Ser Gly Ser Val Gly Ser Ser 
145                 150                 155                 160 


Gly Ile Ser Ser Ile Gly Leu Cys Ala Leu Ser Gly Pro Ala Pro Ala 
                165                 170                 175     


Pro Gln Ser Leu Leu Pro Gly Gln Ser Asn Gln Ala Pro Gly Val Gly 
            180                 185                 190         


Asp Cys Leu Arg Gln Gln Leu Gly Ser Arg Leu Ala Trp Thr Leu Thr 
        195                 200                 205             


Ala Asn Gln Pro Ser Ser Gln Ala Thr Thr Ser Lys Gly Val Pro Ser 
    210                 215                 220                 


Ala Val Ser Arg Asn Met Thr Arg Ser Arg Arg Glu Gly Asp Thr Gly 
225                 230                 235                 240 


Gly Thr Met Glu Ile Thr Glu Ala Ala Leu Val Arg Asp Ile Leu Tyr 
                245                 250                 255     


Val Phe Gln Gly Ile Asp Gly Lys Asn Ile Lys Met Asn Asn Thr Glu 
            260                 265                 270         


Asn Cys Tyr Lys Val Glu Gly Lys Ala Asn Leu Ser Arg Ser Leu Arg 
        275                 280                 285             


Asp Thr Ala Val Arg Leu Ser Glu Leu Gly Trp Leu His Asn Lys Ile 
    290                 295                 300                 


Arg Arg Tyr Thr Asp Gln Arg Ser Leu Asp Arg Ser Phe Gly Leu Val 
305                 310                 315                 320 


Gly Gln Ser Phe Cys Ala Ala Leu His Gln Glu Leu Arg Glu Tyr Tyr 
                325                 330                 335     


Arg Leu Leu Ser Val Leu His Ser Gln Leu Gln Leu Glu Asp Asp Gln 
            340                 345                 350         


Gly Val Asn Leu Gly Leu Glu Ser Ser Leu Thr Leu Arg Arg Leu Leu 
        355                 360                 365             


Val Trp Thr Tyr Asp Pro Lys Ile Arg Leu Lys Thr Leu Ala Ala Leu 
    370                 375                 380                 


Val Asp His Cys Gln Gly Arg Lys Gly Gly Glu Leu Ala Ser Ala Val 
385                 390                 395                 400 


His Ala Tyr Thr Lys Thr Gly Asp Pro Tyr Met Arg Ser Leu Val Gln 
                405                 410                 415     


His Ile Leu Ser Leu Val Ser His Pro Val Leu Ser Phe Leu Tyr Arg 
            420                 425                 430         


Trp Ile Tyr Asp Gly Glu Leu Glu Asp Thr Tyr His Glu Phe Phe Val 
        435                 440                 445             


Ala Ser Asp Pro Thr Val Lys Thr Asp Arg Leu Trp His Asp Lys Tyr 
    450                 455                 460                 


Thr Leu Arg Lys Ser Met Ile Pro Ser Phe Met Thr Met Asp Gln Ser 
465                 470                 475                 480 


Arg Lys Val Leu Leu Ile Gly Lys Ser Ile Asn Phe Leu His Gln Val 
                485                 490                 495     


Cys His Asp Gln Thr Pro Thr Thr Lys Met Ile Ala Val Thr Lys Ser 
            500                 505                 510         


Ala Glu Ser Pro Gln Asp Ala Ala Asp Leu Phe Thr Asp Leu Glu Asn 
        515                 520                 525             


Ala Phe Gln Gly Lys Ile Asp Ala Ala Tyr Phe Glu Thr Ser Lys Tyr 
    530                 535                 540                 


Leu Leu Asp Val Leu Asn Lys Lys Tyr Ser Leu Leu Asp His Met Gln 
545                 550                 555                 560 


Ala Met Arg Arg Tyr Leu Leu Leu Gly Gln Gly Asp Phe Ile Arg His 
                565                 570                 575     


Leu Met Asp Leu Leu Lys Pro Glu Leu Val Arg Pro Ala Thr Thr Leu 
            580                 585                 590         


Tyr Gln His Asn Leu Thr Gly Ile Leu Glu Thr Ala Val Arg Ala Thr 
        595                 600                 605             


Asn Ala Gln Phe Asp Ser Pro Glu Ile Leu Arg Arg Leu Asp Val Arg 
    610                 615                 620                 


Leu Leu Glu Val Ser Pro Gly Asp Thr Gly Trp Asp Val Phe Ser Leu 
625                 630                 635                 640 


Asp Tyr His Val Asp Gly Pro Ile Ala Thr Val Phe Thr Arg Glu Cys 
                645                 650                 655     


Met Ser His Tyr Leu Arg Val Phe Asn Phe Leu Trp Arg Ala Lys Arg 
            660                 665                 670         


Met Glu Tyr Ile Leu Thr Asp Ile Arg Lys Gly His Met Cys Asn Ala 
        675                 680                 685             


Lys Leu Leu Arg Asn Met Pro Glu Phe Ser Gly Val Leu His Gln Cys 
    690                 695                 700                 


His Ile Leu Ala Ser Glu Met Val His Phe Ile His Gln Met Gln Tyr 
705                 710                 715                 720 


Tyr Ile Thr Phe Glu Val Leu Glu Cys Ser Trp Asp Glu Leu Trp Asn 
                725                 730                 735     


Lys Val Gln Gln Ala Gln Asp Leu Asp His Ile Ile Ala Ala His Glu 
            740                 745                 750         


Val Phe Leu Asp Thr Ile Ile Ser Arg Cys Leu Leu Asp Ser Asp Ser 
        755                 760                 765             


Arg Ala Leu Leu Asn Gln Leu Arg Ala Val Phe Asp Gln Ile Ile Glu 
    770                 775                 780                 


Leu Gln Asn Ala Gln Asp Ala Ile Tyr Arg Ala Ala Leu Glu Glu Leu 
785                 790                 795                 800 


Gln Arg Arg Leu Gln Phe Glu Glu Lys Lys Lys Gln Arg Glu Ile Glu 
                805                 810                 815     


Gly Gln Trp Gly Val Thr Ala Ala Glu Glu Glu Glu Glu Asn Lys Arg 
            820                 825                 830         


Ile Gly Glu Phe Lys Glu Ser Ile Pro Lys Met Cys Ser Gln Leu Arg 
        835                 840                 845             


Ile Leu Thr His Phe Tyr Gln Gly Ile Val Gln Gln Phe Leu Val Leu 
    850                 855                 860                 


Leu Thr Thr Ser Ser Asp Glu Ser Leu Arg Phe Leu Ser Phe Arg Leu 
865                 870                 875                 880 


Asp Phe Asn Glu His Tyr Lys Ala Arg Glu Pro Arg Leu Arg Val Ser 
                885                 890                 895     


Leu Gly Thr Arg Gly Arg Arg Ser Ser His Thr 
            900                 905         


<210>  3150
<211>  3861
<212>  DNA
<213>  Homosapiens

<400>  3150
atgtcacatc tggtggaccc tacatcagga gacttgccag ttagagacat agatgctata     60

cctctggtgc taccagcctc aaaaggtaag aatatgaaaa ctcaaccacc cttgagcagg    120

atgaaccggg aggaattgga ggacagtttc tttcgacttc gcgaagatca catgttggtg    180

aaggagcttt cttggaagca acaggatgag atcaaaaggc tgaggaccac cttgctgcgg    240

ttgaccgctg ctggccggga cctgcgggtc gcggaggagg cggcgccgct ctcggagacc    300

gcaaggcgcg ggcagaaggc gggatggcgg cagcgcctct ccatgcacca gcgcccccag    360

atgcaccgac tgcaagggca tttccactgc gtcggccctg ccagcccccg ccgcgcccag    420

cctcgcgtcc aagtgggaca cagacagctc cacacagccg gtgcaccggt gccggagaaa    480

cccaagaggg ggccaaggga caggctgagc tacacagccc ctccatcgtt taaggagcat    540

gcgacaaatg aaaacagagg tgaagtagcc agtaaaccca gtgaacttgt ttctggttct    600

aacagcataa tttctttcag cagtgtcata agtatggcta aacccattgg tctatgcatg    660

cctaacagtg cccacatcat ggccagcaat accatgcaag tggaagagcc acccaagtct    720

cctgagaaaa tgtggcctaa agatgaaaat tttgaacaga gaagctcatt ggagtgtgct    780

cagaaggctg cagagcttcg agcttccatt aaagagaagg tagagctgat tcgacttaag    840

aagctcttac atgaaagaaa tgcttcattg gttatgacaa aagcacaatt aacagaagtt    900

caagaggcat acgaaacctt gctccagaag aatcagggaa tcctgagtgc agcccatgag    960

gccctcctca agcaagtgaa tgagctcagg gcagagctga aggaagaaag caagaaggct   1020

gtgagcttga agagccaact ggaagatgtg tctatcttgc agatgactct gaaggagttt   1080

caggagagag ttgaagattt ggaaaaagaa cgaaaattgc tgaatgacaa ttatgacaaa   1140

ctcttagaaa gcatgctgga cagcagtgac agctccagtc agccccactg gagcaacgag   1200

ctcatagcgg aacagctaca gcagcaagtc tctcagctgc aggatcagct ggatgctgag   1260

ctggaggaca agagaaaagt tttacttgag ctgtccaggg agaaagccca aaatgaggat   1320

ctgaagcttg aagtcaccaa catacttcag aagcataaac aggaagtaga gctcctccaa   1380

aatgcagcca caatttccca acctcctgac aggcaatctg aaccagccac tcacccagct   1440

gtattgcaag agaacactca gatcgagcca agtgaaccca aaaaccaaga agaaaagaaa   1500

ctgtcccagg tgctaaatga gttgcaagta tcacacgcag agaccacatt ggaactagaa   1560

aagaccaggg acatgcttat tctgcagcgc aaaatcaacg tgtgttatca ggaggaactg   1620

gaggcaatga tgacaaaagc tgacaatgat aatagagatc acaaagaaaa gctggagagg   1680

ttgactcgac tactagacct caagaataac cgtatcaagc agctggaagg tattttaaga   1740

agccatgacc ttccaacatc tgaacagctc aaagatgttg cttatggcac ccgaccgttg   1800

tcgttatgtt tggaaacact gccagcccat ggagatgagg ataaagtgga tatttctctg   1860

ctgcatcagg gtgagaatct ttttgaactg cacatccacc aggccttcct gacatctgcc   1920

gccctagctc aggctggaga tacccaacct accactttct gcacctattc cttctatgac   1980

tttgaaaccc actgtacccc attatctgtg gggccacagc ccctctatga cttcacctcc   2040

cagtatgtga tggagacaga ttcgcttttc ttacactacc ttcaagaggc ttcagcccgg   2100

cttgacatac accaggccat ggccagtgaa cacagcactc ttgctgcagg atggatttgc   2160

tttgacaggg tgctagagac tgtggagaaa gtccatggct tggccacact gattggagct   2220

ggtggagaag agttcggggt tctagagtac tggatgaggc tgcgtttccc cataaaaccc   2280

agcctacagg cgtgcaataa acgaaagaaa gcccaggtct acctgtcaac cgatgtgctt   2340

ggaggccgga aggcccagga agaggagttc agatcggagt cttgggaacc tcagaacgag   2400

ctgtggattg aaatcaccaa gtgctgtggc ctccggagtc gatggctggg aactcaaccc   2460

agtccatatg ctgtgtaccg cttcttcacc ttttctgacc atgacactgc catcattcca   2520

gccagtaaca acccctactt tagagaccag gctcgattcc cagtgcttgt gacctctgac   2580

ctggaccatt atctgagacg ggaggccttg tctatacatg tttttgatga tgaagactta   2640

gagcctggct cgtatcttgg ccgagcccga gtgcctttac tgcctcttgc aaaaaatgaa   2700

tctatcaaag gtgattttaa cctcactgac cctgcagaga aacccaacgg atctattcaa   2760

gtgcaactgg attggaagtt tccctacata ccccctgaga gcttcctgaa accagaagct   2820

cagactaagg ggaaggatac caaggacagt tcaaagatct catctgaaga ggaaaaggct   2880

tcatttcctt cccaggatca gatggcatct cctgaggttc ccattgaagc tggccagtat   2940

cgatctaaga gaaaacctcc tcatggggga gaaagaaagg agaaggagca ccaggttgtg   3000

agctactcaa gaagaaaaca tggcaaaaga ataggtgttc aaggaaagaa tagaatggag   3060

tatcttagcc ttaacatctt aaatggaaat acaccacagc aggtgaatta cactgagtgg   3120

aagttctcag agactaacag cttcataggt gatggcttta aaaatcagca cgaggaagag   3180

gaaatgacat tatcccattc agcactgaaa cagaaggaac ctctacatcc tgtaaatgac   3240

aaagaatcct ctgaacaagg ttctgaagtc agtgaagcac aaactaccga cagtgatgat   3300

gtcatagtgc cacccatgtc tcagaaatat cctaaggcag attcagagaa gatgtgcatt   3360

gaaattgtct ccctggcctt ctacccagag gcagaagtga tgtctgatga gaacataaaa   3420

caggtgtatg tggagtacaa attctacgac ctacccttgt cggagacaga gactccagtg   3480

tccctaagga agcctagggc aggagaagaa atccactttc actttagcaa ggtaatagac   3540

ctggacccac aggagcagca aggccgaagg cggtttctgt tcgacatgct gaatggacaa   3600

gatcctgatc aaggacattt aaagtttaca gtggtaagtg atcctctgga tgaagaaaag   3660

aaagaatgtg aagaagtggg atatgcatat cttcaactgt ggcagatcct ggagtcagga   3720

agagatattc tagagcaaga gctagacatt gttagccctg aagatctggc taccccaata   3780

ggaaggctga aggtttccct tcaagcagct gctgtcctcc atgctattta caaggagatg   3840

actgaagatt tgttttcatg a                                             3861


<210>  3151
<211>  1286
<212>  PRT
<213>  Homosapiens

<400>  3151

Met Ser His Leu Val Asp Pro Thr Ser Gly Asp Leu Pro Val Arg Asp 
1               5                   10                  15      


Ile Asp Ala Ile Pro Leu Val Leu Pro Ala Ser Lys Gly Lys Asn Met 
            20                  25                  30          


Lys Thr Gln Pro Pro Leu Ser Arg Met Asn Arg Glu Glu Leu Glu Asp 
        35                  40                  45              


Ser Phe Phe Arg Leu Arg Glu Asp His Met Leu Val Lys Glu Leu Ser 
    50                  55                  60                  


Trp Lys Gln Gln Asp Glu Ile Lys Arg Leu Arg Thr Thr Leu Leu Arg 
65                  70                  75                  80  


Leu Thr Ala Ala Gly Arg Asp Leu Arg Val Ala Glu Glu Ala Ala Pro 
                85                  90                  95      


Leu Ser Glu Thr Ala Arg Arg Gly Gln Lys Ala Gly Trp Arg Gln Arg 
            100                 105                 110         


Leu Ser Met His Gln Arg Pro Gln Met His Arg Leu Gln Gly His Phe 
        115                 120                 125             


His Cys Val Gly Pro Ala Ser Pro Arg Arg Ala Gln Pro Arg Val Gln 
    130                 135                 140                 


Val Gly His Arg Gln Leu His Thr Ala Gly Ala Pro Val Pro Glu Lys 
145                 150                 155                 160 


Pro Lys Arg Gly Pro Arg Asp Arg Leu Ser Tyr Thr Ala Pro Pro Ser 
                165                 170                 175     


Phe Lys Glu His Ala Thr Asn Glu Asn Arg Gly Glu Val Ala Ser Lys 
            180                 185                 190         


Pro Ser Glu Leu Val Ser Gly Ser Asn Ser Ile Ile Ser Phe Ser Ser 
        195                 200                 205             


Val Ile Ser Met Ala Lys Pro Ile Gly Leu Cys Met Pro Asn Ser Ala 
    210                 215                 220                 


His Ile Met Ala Ser Asn Thr Met Gln Val Glu Glu Pro Pro Lys Ser 
225                 230                 235                 240 


Pro Glu Lys Met Trp Pro Lys Asp Glu Asn Phe Glu Gln Arg Ser Ser 
                245                 250                 255     


Leu Glu Cys Ala Gln Lys Ala Ala Glu Leu Arg Ala Ser Ile Lys Glu 
            260                 265                 270         


Lys Val Glu Leu Ile Arg Leu Lys Lys Leu Leu His Glu Arg Asn Ala 
        275                 280                 285             


Ser Leu Val Met Thr Lys Ala Gln Leu Thr Glu Val Gln Glu Ala Tyr 
    290                 295                 300                 


Glu Thr Leu Leu Gln Lys Asn Gln Gly Ile Leu Ser Ala Ala His Glu 
305                 310                 315                 320 


Ala Leu Leu Lys Gln Val Asn Glu Leu Arg Ala Glu Leu Lys Glu Glu 
                325                 330                 335     


Ser Lys Lys Ala Val Ser Leu Lys Ser Gln Leu Glu Asp Val Ser Ile 
            340                 345                 350         


Leu Gln Met Thr Leu Lys Glu Phe Gln Glu Arg Val Glu Asp Leu Glu 
        355                 360                 365             


Lys Glu Arg Lys Leu Leu Asn Asp Asn Tyr Asp Lys Leu Leu Glu Ser 
    370                 375                 380                 


Met Leu Asp Ser Ser Asp Ser Ser Ser Gln Pro His Trp Ser Asn Glu 
385                 390                 395                 400 


Leu Ile Ala Glu Gln Leu Gln Gln Gln Val Ser Gln Leu Gln Asp Gln 
                405                 410                 415     


Leu Asp Ala Glu Leu Glu Asp Lys Arg Lys Val Leu Leu Glu Leu Ser 
            420                 425                 430         


Arg Glu Lys Ala Gln Asn Glu Asp Leu Lys Leu Glu Val Thr Asn Ile 
        435                 440                 445             


Leu Gln Lys His Lys Gln Glu Val Glu Leu Leu Gln Asn Ala Ala Thr 
    450                 455                 460                 


Ile Ser Gln Pro Pro Asp Arg Gln Ser Glu Pro Ala Thr His Pro Ala 
465                 470                 475                 480 


Val Leu Gln Glu Asn Thr Gln Ile Glu Pro Ser Glu Pro Lys Asn Gln 
                485                 490                 495     


Glu Glu Lys Lys Leu Ser Gln Val Leu Asn Glu Leu Gln Val Ser His 
            500                 505                 510         


Ala Glu Thr Thr Leu Glu Leu Glu Lys Thr Arg Asp Met Leu Ile Leu 
        515                 520                 525             


Gln Arg Lys Ile Asn Val Cys Tyr Gln Glu Glu Leu Glu Ala Met Met 
    530                 535                 540                 


Thr Lys Ala Asp Asn Asp Asn Arg Asp His Lys Glu Lys Leu Glu Arg 
545                 550                 555                 560 


Leu Thr Arg Leu Leu Asp Leu Lys Asn Asn Arg Ile Lys Gln Leu Glu 
                565                 570                 575     


Gly Ile Leu Arg Ser His Asp Leu Pro Thr Ser Glu Gln Leu Lys Asp 
            580                 585                 590         


Val Ala Tyr Gly Thr Arg Pro Leu Ser Leu Cys Leu Glu Thr Leu Pro 
        595                 600                 605             


Ala His Gly Asp Glu Asp Lys Val Asp Ile Ser Leu Leu His Gln Gly 
    610                 615                 620                 


Glu Asn Leu Phe Glu Leu His Ile His Gln Ala Phe Leu Thr Ser Ala 
625                 630                 635                 640 


Ala Leu Ala Gln Ala Gly Asp Thr Gln Pro Thr Thr Phe Cys Thr Tyr 
                645                 650                 655     


Ser Phe Tyr Asp Phe Glu Thr His Cys Thr Pro Leu Ser Val Gly Pro 
            660                 665                 670         


Gln Pro Leu Tyr Asp Phe Thr Ser Gln Tyr Val Met Glu Thr Asp Ser 
        675                 680                 685             


Leu Phe Leu His Tyr Leu Gln Glu Ala Ser Ala Arg Leu Asp Ile His 
    690                 695                 700                 


Gln Ala Met Ala Ser Glu His Ser Thr Leu Ala Ala Gly Trp Ile Cys 
705                 710                 715                 720 


Phe Asp Arg Val Leu Glu Thr Val Glu Lys Val His Gly Leu Ala Thr 
                725                 730                 735     


Leu Ile Gly Ala Gly Gly Glu Glu Phe Gly Val Leu Glu Tyr Trp Met 
            740                 745                 750         


Arg Leu Arg Phe Pro Ile Lys Pro Ser Leu Gln Ala Cys Asn Lys Arg 
        755                 760                 765             


Lys Lys Ala Gln Val Tyr Leu Ser Thr Asp Val Leu Gly Gly Arg Lys 
    770                 775                 780                 


Ala Gln Glu Glu Glu Phe Arg Ser Glu Ser Trp Glu Pro Gln Asn Glu 
785                 790                 795                 800 


Leu Trp Ile Glu Ile Thr Lys Cys Cys Gly Leu Arg Ser Arg Trp Leu 
                805                 810                 815     


Gly Thr Gln Pro Ser Pro Tyr Ala Val Tyr Arg Phe Phe Thr Phe Ser 
            820                 825                 830         


Asp His Asp Thr Ala Ile Ile Pro Ala Ser Asn Asn Pro Tyr Phe Arg 
        835                 840                 845             


Asp Gln Ala Arg Phe Pro Val Leu Val Thr Ser Asp Leu Asp His Tyr 
    850                 855                 860                 


Leu Arg Arg Glu Ala Leu Ser Ile His Val Phe Asp Asp Glu Asp Leu 
865                 870                 875                 880 


Glu Pro Gly Ser Tyr Leu Gly Arg Ala Arg Val Pro Leu Leu Pro Leu 
                885                 890                 895     


Ala Lys Asn Glu Ser Ile Lys Gly Asp Phe Asn Leu Thr Asp Pro Ala 
            900                 905                 910         


Glu Lys Pro Asn Gly Ser Ile Gln Val Gln Leu Asp Trp Lys Phe Pro 
        915                 920                 925             


Tyr Ile Pro Pro Glu Ser Phe Leu Lys Pro Glu Ala Gln Thr Lys Gly 
    930                 935                 940                 


Lys Asp Thr Lys Asp Ser Ser Lys Ile Ser Ser Glu Glu Glu Lys Ala 
945                 950                 955                 960 


Ser Phe Pro Ser Gln Asp Gln Met Ala Ser Pro Glu Val Pro Ile Glu 
                965                 970                 975     


Ala Gly Gln Tyr Arg Ser Lys Arg Lys Pro Pro His Gly Gly Glu Arg 
            980                 985                 990         


Lys Glu Lys Glu His Gln Val Val  Ser Tyr Ser Arg Arg  Lys His Gly 
        995                 1000                 1005             


Lys Arg  Ile Gly Val Gln Gly  Lys Asn Arg Met Glu  Tyr Leu Ser 
    1010                 1015                 1020             


Leu Asn  Ile Leu Asn Gly Asn  Thr Pro Gln Gln Val  Asn Tyr Thr 
    1025                 1030                 1035             


Glu Trp  Lys Phe Ser Glu Thr  Asn Ser Phe Ile Gly  Asp Gly Phe 
    1040                 1045                 1050             


Lys Asn  Gln His Glu Glu Glu  Glu Met Thr Leu Ser  His Ser Ala 
    1055                 1060                 1065             


Leu Lys  Gln Lys Glu Pro Leu  His Pro Val Asn Asp  Lys Glu Ser 
    1070                 1075                 1080             


Ser Glu  Gln Gly Ser Glu Val  Ser Glu Ala Gln Thr  Thr Asp Ser 
    1085                 1090                 1095             


Asp Asp  Val Ile Val Pro Pro  Met Ser Gln Lys Tyr  Pro Lys Ala 
    1100                 1105                 1110             


Asp Ser  Glu Lys Met Cys Ile  Glu Ile Val Ser Leu  Ala Phe Tyr 
    1115                 1120                 1125             


Pro Glu  Ala Glu Val Met Ser  Asp Glu Asn Ile Lys  Gln Val Tyr 
    1130                 1135                 1140             


Val Glu  Tyr Lys Phe Tyr Asp  Leu Pro Leu Ser Glu  Thr Glu Thr 
    1145                 1150                 1155             


Pro Val  Ser Leu Arg Lys Pro  Arg Ala Gly Glu Glu  Ile His Phe 
    1160                 1165                 1170             


His Phe  Ser Lys Val Ile Asp  Leu Asp Pro Gln Glu  Gln Gln Gly 
    1175                 1180                 1185             


Arg Arg  Arg Phe Leu Phe Asp  Met Leu Asn Gly Gln  Asp Pro Asp 
    1190                 1195                 1200             


Gln Gly  His Leu Lys Phe Thr  Val Val Ser Asp Pro  Leu Asp Glu 
    1205                 1210                 1215             


Glu Lys  Lys Glu Cys Glu Glu  Val Gly Tyr Ala Tyr  Leu Gln Leu 
    1220                 1225                 1230             


Trp Gln  Ile Leu Glu Ser Gly  Arg Asp Ile Leu Glu  Gln Glu Leu 
    1235                 1240                 1245             


Asp Ile  Val Ser Pro Glu Asp  Leu Ala Thr Pro Ile  Gly Arg Leu 
    1250                 1255                 1260             


Lys Val  Ser Leu Gln Ala Ala  Ala Val Leu His Ala  Ile Tyr Lys 
    1265                 1270                 1275             


Glu Met  Thr Glu Asp Leu Phe  Ser 
    1280                 1285     


<210>  3152
<211>  4696
<212>  DNA
<213>  Homosapiens

<400>  3152
ggcagaccgt cacgtgacga cgtcgattcg cgtgcggcag tggcgaagtt gacaaacccc     60

gcgaaaatcg actctttgca tcgcacattt tgttgatttt ccctcgtttt tctttctctc    120

tttcccccgt ccatccgaaa gagggttgga aaaaaacaaa acaaacaaac aaacaaaaaa    180

aaaacctaac gctgttggga cccggaagcg gaaagggcat ctttgaggtc gatacttccg    240

ggtcattggg agagtgcggg attcctgggc cgagagcggg tggctgagcc gggacctcgc    300

gtgattctcg gaacccgagg agaagcggcg tccggggcta tggctgtgac tctggacaaa    360

gacgcttatt atcggcgagt gaagagactg tacagcaatt ggcggaaagg agaagatgag    420

tatgccaacg ttgatgccat tgttgtatca gtgggtgttg atgaagaaat tgtttatgcc    480

aaatcaactg ccttacagac atggctcttt ggttatgaac taactgatac tatcatggtc    540

ttttgtgatg acaaaatcat ctttatggcc agcaagaaaa aagtggagtt cttgaaacag    600

attgccaaca ctaagggcaa tgagaatgct aatggagccc ctgccatcac actgctaata    660

cgagaaaaga atgaaagtaa taagagtagc tttgacaaaa tgattgaagc cattaaagaa    720

agcaagaatg gcaagaagat tggagtgttc agcaaagaca aattccctgg agagttcatg    780

aagagctgga atgactgcct caacaaagaa ggctttgaca aaatagatat cagtgcagtt    840

gtggcatata ccatcgctgt aaaggaggat ggggagctca acctaatgaa gaaagcagcc    900

agcatcactt ctgaagtctt caacaaattc ttcaaggaaa gagtcatgga aatagttgat    960

gcagatgaga aagttcgaca cagcaaactg gctgagtctg tggaaaaggc cattgaagag   1020

aaaaaatacc ttgctggggc agacccttct actgtggaaa tgtgttaccc tcctatcatt   1080

cagagtggtg gcaactataa tctcaagttc agtgtggtga gtgacaagaa tcatatgcac   1140

tttggggcta tcacttgtgc catgggtatt cgcttcaagt cttactgctc caaccttgtt   1200

cgcactttga tggttgatcc ttctcaagaa gttcaagaaa attataactt tttgctccag   1260

cttcaagagg agctgctgaa ggaattaaga catggtgtga agatatgtga cgtgtataac   1320

gctgtcatgg acgtggttaa aaagcagaag ccagaactgc tgaacaaaat taccaaaaac   1380

ctagggtttg ggatgggaat tgaattccgt gaaggctccc tagtaatcaa tagcaaaaat   1440

caatacaaac tgaagaaagg aatggttttc agcatcaatt taggattctc agacctgact   1500

aacaaggagg ggaaaaagcc agaagagaaa acctatgccc tgttcattgg tgacacagtg   1560

cttgtggatg aggatggccc agctactgtt ctcacttctg tgaagaagaa agtgaagaat   1620

gtggggattt tcctaaagaa tgaagatgag gaagaagagg aggaggagaa agatgaggca   1680

gaggaccttt tgggaagagg ttctcgggca gcattactta cagaaagaac aagaaatgaa   1740

atgactgcag aagagaagcg aagagcacat cagaaagaac tagcggctca actcaatgaa   1800

gaagcaaaga ggcgattgac tgaacaaaag ggagaacagc agattcagaa agctcgcaag   1860

tctaatgtgt cctataaaaa cccatctctg atgcctaagg aaccgcatat tcgggaaatg   1920

aagatctaca tcgataagaa atatgagact gtaataatgc ccgtgtttgg cattgcaaca   1980

ccgtttcaca ttgccacaat caagaatata agtatgtccg tggaaggaga ttatacttac   2040

ttgcgaatca acttttattg cccaggcagt gctctgggca ggaatgaagg caacatcttt   2100

cctaaccctg aagcgacttt tgtcaaggaa attacatacc gagcatcaaa tattaaggca   2160

cccggagaac agacagtacc agccttgaac cttcagaatg ctttccgaat tattaaagaa   2220

gtacagaaac gttataaaac tcgagaagct gaagagaaag agaaggaggg gattgtaaaa   2280

caagactcac tggtgatcaa tctaaaccgg agtaatccga aactgaaaga tctatacatt   2340

cgcccaaata ttgcccaaaa gaggatgcaa ggctcactgg aggcccatgt caatggcttc   2400

cgcttcacat ctgttcgagg agacaaagtg gatattttgt acaataatat taagcatgct   2460

ttgttccagc cctgtgatgg agaaatgatt attgtcttgc actttcacct caagaatgcc   2520

atcatgtttg ggaagaagcg gcacacggat gtgcagttct acacagaagt gggagagata   2580

accacggact tggggaaaca tcagcatatg catgaccgag atgacctcta tgctgagcag   2640

atggaacgag aaatgaggca caaactgaaa acagccttta aaaatttcat tgagaaagta   2700

gaggctctaa ctaaggagga actggaattt gaagtgcctt ttagggactt gggatttaac   2760

ggagctccct ataggagtac ctgcctcctt cagcccacta gtagtgcgct ggtaaatgct   2820

acggaatggc caccttttgt ggtgacattg gatgaggtag agctgatcca ctttgagcgg   2880

gtccagtttc acctgaagaa ctttgatatg gtaatcgtct acaaggacta cagcaagaaa   2940

gtgaccatga tcaacgccat tcctgtagcc tctcttgacc ccatcaagga atggttgaat   3000

tcctgcgacc tgaaatacac agaaggagta cagtccctca actggactaa aatcatgaag   3060

accattgttg atgaccctga gggcttcttc gaacaaggtg gctggtcttt cctggagcct   3120

gagggtgagg ggagtgatgc tgaagaaggg gattcagagt ctgaaattga agatgagact   3180

tttaatcctt cagaagatga ctatgaagag gaagaggagg acagtgatga agattattca   3240

tcagaagcag aagagtcaga ctattctaag gagtcattgg gtagtgaaga agagagtgga   3300

aaggattggg atgaactgga ggaagaagcc cgaaaagcgg accgagaaag tcgttacgag   3360

gaagaagaag aacaaagtcg aagtatgagc cggaagagga aggcatctgt gcacagttcg   3420

ggccgtggct ctaaccgtgg ttccagacac agctctgcac cccccaagaa aaagaggaag   3480

taacttctga actttggccc tgagctccat tcttcctcca gccaacccct gaaaatttta   3540

catgacatag aaactgtatt tttcctttcg ttttcatttg aagttttgcc atttgtgttt   3600

atgggtttag ggggccattt gtgtggacca atctactcgg ggaattccag gcccaccagg   3660

acacgtgcca atggccccat tcagatggca agggaggagg tgttcttgaa gacaggagga   3720

ggctcccgct gttaataaat attgtttcat tcttctctct tcctgtcacc ttctgccaag   3780

acattgatgg cttctgacat cttatttggt gtctcaaagc tgtatttcca agacagtggt   3840

acaaggtgac ccttaattac ccgtatcatg gttcttgacc agcacattca atcctccaac   3900

ctaccctact gccatgacct tccgcacatc tctaagtttt atctttgcaa tactcaaggt   3960

tctcggaaat ttgctaatgg ttgtgataaa ccatacagct tgagccagtg aggcagattg   4020

ggctggtgcc ttcgtctgag ttttcctgct ttcctgcctc gtgcagattc tgaggtatat   4080

ctgctgcctt ggaagacata agaagcagtg atactccctg gctcggttat tttctccata   4140

caatgcacac atggtacaat gatagaaggc aaaattgcca ctgtcttctt ttttttctca   4200

tatatctaag gaagatatat caggttgtgc ctcatgtacc gcttctagtg aaatgtagag   4260

gaaggctcaa aggagtcaac atttagatct ggaagggaca agtcatgcct tgggcctaga   4320

ataccctgat gagaaaagag aagaggaagg gaggccatat ctacaacaca gcctctcggc   4380

actgctgctc cttattttaa ctttgtcttg cattgtcctg tatttatcac agtttctgtt   4440

gaacagcttt tcaagtattt ggggagttta tcttgccatc ctccccttct ggttctctgc   4500

acccacctgt cccactgcag ttccttccgt gctctgtgac tttaagagaa gaagggggga   4560

ggggtcccgg attttatgtt tgtttgtttt ttctccttag cagtaggact tgatattttc   4620

aattttggaa gaactaaaag atgaataaac tgggtttttt ttgttgtttg tttttgtaaa   4680

aaaaaaaaaa aaaaaa                                                   4696


<210>  3153
<211>  1047
<212>  PRT
<213>  Homosapiens

<400>  3153

Met Ala Val Thr Leu Asp Lys Asp Ala Tyr Tyr Arg Arg Val Lys Arg 
1               5                   10                  15      


Leu Tyr Ser Asn Trp Arg Lys Gly Glu Asp Glu Tyr Ala Asn Val Asp 
            20                  25                  30          


Ala Ile Val Val Ser Val Gly Val Asp Glu Glu Ile Val Tyr Ala Lys 
        35                  40                  45              


Ser Thr Ala Leu Gln Thr Trp Leu Phe Gly Tyr Glu Leu Thr Asp Thr 
    50                  55                  60                  


Ile Met Val Phe Cys Asp Asp Lys Ile Ile Phe Met Ala Ser Lys Lys 
65                  70                  75                  80  


Lys Val Glu Phe Leu Lys Gln Ile Ala Asn Thr Lys Gly Asn Glu Asn 
                85                  90                  95      


Ala Asn Gly Ala Pro Ala Ile Thr Leu Leu Ile Arg Glu Lys Asn Glu 
            100                 105                 110         


Ser Asn Lys Ser Ser Phe Asp Lys Met Ile Glu Ala Ile Lys Glu Ser 
        115                 120                 125             


Lys Asn Gly Lys Lys Ile Gly Val Phe Ser Lys Asp Lys Phe Pro Gly 
    130                 135                 140                 


Glu Phe Met Lys Ser Trp Asn Asp Cys Leu Asn Lys Glu Gly Phe Asp 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Ala Val Val Ala Tyr Thr Ile Ala Val Lys Glu 
                165                 170                 175     


Asp Gly Glu Leu Asn Leu Met Lys Lys Ala Ala Ser Ile Thr Ser Glu 
            180                 185                 190         


Val Phe Asn Lys Phe Phe Lys Glu Arg Val Met Glu Ile Val Asp Ala 
        195                 200                 205             


Asp Glu Lys Val Arg His Ser Lys Leu Ala Glu Ser Val Glu Lys Ala 
    210                 215                 220                 


Ile Glu Glu Lys Lys Tyr Leu Ala Gly Ala Asp Pro Ser Thr Val Glu 
225                 230                 235                 240 


Met Cys Tyr Pro Pro Ile Ile Gln Ser Gly Gly Asn Tyr Asn Leu Lys 
                245                 250                 255     


Phe Ser Val Val Ser Asp Lys Asn His Met His Phe Gly Ala Ile Thr 
            260                 265                 270         


Cys Ala Met Gly Ile Arg Phe Lys Ser Tyr Cys Ser Asn Leu Val Arg 
        275                 280                 285             


Thr Leu Met Val Asp Pro Ser Gln Glu Val Gln Glu Asn Tyr Asn Phe 
    290                 295                 300                 


Leu Leu Gln Leu Gln Glu Glu Leu Leu Lys Glu Leu Arg His Gly Val 
305                 310                 315                 320 


Lys Ile Cys Asp Val Tyr Asn Ala Val Met Asp Val Val Lys Lys Gln 
                325                 330                 335     


Lys Pro Glu Leu Leu Asn Lys Ile Thr Lys Asn Leu Gly Phe Gly Met 
            340                 345                 350         


Gly Ile Glu Phe Arg Glu Gly Ser Leu Val Ile Asn Ser Lys Asn Gln 
        355                 360                 365             


Tyr Lys Leu Lys Lys Gly Met Val Phe Ser Ile Asn Leu Gly Phe Ser 
    370                 375                 380                 


Asp Leu Thr Asn Lys Glu Gly Lys Lys Pro Glu Glu Lys Thr Tyr Ala 
385                 390                 395                 400 


Leu Phe Ile Gly Asp Thr Val Leu Val Asp Glu Asp Gly Pro Ala Thr 
                405                 410                 415     


Val Leu Thr Ser Val Lys Lys Lys Val Lys Asn Val Gly Ile Phe Leu 
            420                 425                 430         


Lys Asn Glu Asp Glu Glu Glu Glu Glu Glu Glu Lys Asp Glu Ala Glu 
        435                 440                 445             


Asp Leu Leu Gly Arg Gly Ser Arg Ala Ala Leu Leu Thr Glu Arg Thr 
    450                 455                 460                 


Arg Asn Glu Met Thr Ala Glu Glu Lys Arg Arg Ala His Gln Lys Glu 
465                 470                 475                 480 


Leu Ala Ala Gln Leu Asn Glu Glu Ala Lys Arg Arg Leu Thr Glu Gln 
                485                 490                 495     


Lys Gly Glu Gln Gln Ile Gln Lys Ala Arg Lys Ser Asn Val Ser Tyr 
            500                 505                 510         


Lys Asn Pro Ser Leu Met Pro Lys Glu Pro His Ile Arg Glu Met Lys 
        515                 520                 525             


Ile Tyr Ile Asp Lys Lys Tyr Glu Thr Val Ile Met Pro Val Phe Gly 
    530                 535                 540                 


Ile Ala Thr Pro Phe His Ile Ala Thr Ile Lys Asn Ile Ser Met Ser 
545                 550                 555                 560 


Val Glu Gly Asp Tyr Thr Tyr Leu Arg Ile Asn Phe Tyr Cys Pro Gly 
                565                 570                 575     


Ser Ala Leu Gly Arg Asn Glu Gly Asn Ile Phe Pro Asn Pro Glu Ala 
            580                 585                 590         


Thr Phe Val Lys Glu Ile Thr Tyr Arg Ala Ser Asn Ile Lys Ala Pro 
        595                 600                 605             


Gly Glu Gln Thr Val Pro Ala Leu Asn Leu Gln Asn Ala Phe Arg Ile 
    610                 615                 620                 


Ile Lys Glu Val Gln Lys Arg Tyr Lys Thr Arg Glu Ala Glu Glu Lys 
625                 630                 635                 640 


Glu Lys Glu Gly Ile Val Lys Gln Asp Ser Leu Val Ile Asn Leu Asn 
                645                 650                 655     


Arg Ser Asn Pro Lys Leu Lys Asp Leu Tyr Ile Arg Pro Asn Ile Ala 
            660                 665                 670         


Gln Lys Arg Met Gln Gly Ser Leu Glu Ala His Val Asn Gly Phe Arg 
        675                 680                 685             


Phe Thr Ser Val Arg Gly Asp Lys Val Asp Ile Leu Tyr Asn Asn Ile 
    690                 695                 700                 


Lys His Ala Leu Phe Gln Pro Cys Asp Gly Glu Met Ile Ile Val Leu 
705                 710                 715                 720 


His Phe His Leu Lys Asn Ala Ile Met Phe Gly Lys Lys Arg His Thr 
                725                 730                 735     


Asp Val Gln Phe Tyr Thr Glu Val Gly Glu Ile Thr Thr Asp Leu Gly 
            740                 745                 750         


Lys His Gln His Met His Asp Arg Asp Asp Leu Tyr Ala Glu Gln Met 
        755                 760                 765             


Glu Arg Glu Met Arg His Lys Leu Lys Thr Ala Phe Lys Asn Phe Ile 
    770                 775                 780                 


Glu Lys Val Glu Ala Leu Thr Lys Glu Glu Leu Glu Phe Glu Val Pro 
785                 790                 795                 800 


Phe Arg Asp Leu Gly Phe Asn Gly Ala Pro Tyr Arg Ser Thr Cys Leu 
                805                 810                 815     


Leu Gln Pro Thr Ser Ser Ala Leu Val Asn Ala Thr Glu Trp Pro Pro 
            820                 825                 830         


Phe Val Val Thr Leu Asp Glu Val Glu Leu Ile His Phe Glu Arg Val 
        835                 840                 845             


Gln Phe His Leu Lys Asn Phe Asp Met Val Ile Val Tyr Lys Asp Tyr 
    850                 855                 860                 


Ser Lys Lys Val Thr Met Ile Asn Ala Ile Pro Val Ala Ser Leu Asp 
865                 870                 875                 880 


Pro Ile Lys Glu Trp Leu Asn Ser Cys Asp Leu Lys Tyr Thr Glu Gly 
                885                 890                 895     


Val Gln Ser Leu Asn Trp Thr Lys Ile Met Lys Thr Ile Val Asp Asp 
            900                 905                 910         


Pro Glu Gly Phe Phe Glu Gln Gly Gly Trp Ser Phe Leu Glu Pro Glu 
        915                 920                 925             


Gly Glu Gly Ser Asp Ala Glu Glu Gly Asp Ser Glu Ser Glu Ile Glu 
    930                 935                 940                 


Asp Glu Thr Phe Asn Pro Ser Glu Asp Asp Tyr Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Asp Ser Asp Glu Asp Tyr Ser Ser Glu Ala Glu Glu Ser Asp Tyr Ser 
                965                 970                 975     


Lys Glu Ser Leu Gly Ser Glu Glu Glu Ser Gly Lys Asp Trp Asp Glu 
            980                 985                 990         


Leu Glu Glu Glu Ala Arg Lys Ala  Asp Arg Glu Ser Arg  Tyr Glu Glu 
        995                 1000                 1005             


Glu Glu  Glu Gln Ser Arg Ser  Met Ser Arg Lys Arg  Lys Ala Ser 
    1010                 1015                 1020             


Val His  Ser Ser Gly Arg Gly  Ser Asn Arg Gly Ser  Arg His Ser 
    1025                 1030                 1035             


Ser Ala  Pro Pro Lys Lys Lys  Arg Lys 
    1040                 1045         


<210>  3154
<211>  7147
<212>  DNA
<213>  Homosapiens

<400>  3154
tgctggagag acagggagag gggcgaaccg gccccccaca gccactgcag gagttccacc     60

atcttcctct gaagacgtag ccatcttgct ccatgaaggg tgaatcgaaa cgcatcaccc    120

tggtcctcca gcagccacag tctggaggtc cccaaggaca tcggcatgtt gtgctaggga    180

gtctaccagg caagatagtg ttacagggca accagctggc agccctgact caagccaaga    240

atgcccaagg gcagcctgcc aaggtagtaa ctatccagct gcaggtgcag cagccacagc    300

aaaaaatcca gattgtacca caaccaccat catcgcagcc acagccccag cagccaccct    360

ccacccagcc agtgactctg tcctctgtac agcaggctca gataatggga ccaggacaaa    420

gcccaggaca aagactttca gtaccagtca aggtggtact gcagccacag gctggctctt    480

cccaaggggc ctcttctggg ctctctgtag ttaaagttct gagtgccagt gaagtggcag    540

ctttgtcatc accagcaagc tctgctcctc attcgggggg aaagacagga atggaggaaa    600

accgcagatt ggaacaccag aagaagcaag agaaagcaaa tcggattgta gcagaggcca    660

ttgcgagagc ccgtgcccgc ggtgagcaga acatacctcg agtcttaaat gaggacgagt    720

tgcccagcgt tcggccagag gaggaaggcg agaagaaacg caggaagaag agtgctgggg    780

agaggctgaa agaggagaag ccaaagaaga gtaaaacatc tggtgcctcc aaaacaaagg    840

gcaagagcaa gctcaacacc atcactcctg tagtgggtaa gaagagaaaa cgtaatacct    900

catctgataa ttcagatgtg gaagtcatgc ctgcacagtc acctcgagaa gatgaagaaa    960

gcagcattca gaagagacgc tcaaaccgcc aagttaagcg aaaaaaatat acagaggacc   1020

tggatataaa gatcgcagat gatgaagaag aagaagaggt ggatgtaact ggtccaataa   1080

aacctgagcc tatcctccct gaaccagtgc aagaaccaga tggcgagact ttgccttcca   1140

tgcagttctt tgtggagaat cccagtgaag aagatgcagc cattgtagac aaagtgcttt   1200

ctatgcggat tgtgaagaag gagctccctt ctggacaata tactgaagca gaagaattct   1260

ttgtcaagta caagaactac tcctatctgc attgtgaatg ggctactatc tcccaactag   1320

agaaggataa gaggatacat caaaaattaa agcgcttcaa aaccaaaatg gctcagatga   1380

gacacttctt ccatgaggat gaagagccct ttaatccaga ctacgtagag gtggatagga   1440

tattggatga gtctcacagt attgacaagg acaatgggga gcccgttatt tactacctgg   1500

tgaaatggtg ctctctgccc tatgaggata gcacatggga gctaaaagaa gatgttgatg   1560

agggcaagat tcgagaattt aaacggattc agtcaaggca cccagaactc aaaagggtga   1620

atcgtccgca ggcaagtgcc tggaagaaat tggagctatc acatgaatat aaaaacagaa   1680

accagctacg ggaatatcag ttggaagggg ttaattggct gctctttaat tggtataaca   1740

ggcagaactg catcctggct gatgagatgg gattgggcaa aactattcag tccattgcct   1800

tcttgcagga agtatataat gtgggcatcc atggtccctt cttggtcatt gccccactgt   1860

ccacaattac taactgggag cgagaattta atacatggac agaaatgaac actattgtgt   1920

accatggcag tctggccagc aggcagatga ttcaacagta tgaaatgtac tgcaaagatt   1980

cacggggacg cctcatccca ggcgcataca agtttgacgc tctgatcacc acttttgaga   2040

tgattttgtc agattgtcct gagcttcgtg aaattgaatg gcgttgtgtt atcattgatg   2100

aagcccatcg actgaaaaac cgtaattgca agctgcttga tagtctcaag cacatggacc   2160

tggaacacaa ggtgctactc acaggaacac cattgcaaaa tactgtagaa gaactgttta   2220

gcttgcttca tttcttggaa ccgtcacaat ttccctcaga atcagagttt ctcaagaact   2280

ttggggatct caagacagag gaacaggttc aaaagctaca ggccattctt aagccaatga   2340

tgctgagaag actcaaagag gatgttgaaa aaaacttggc acccaaacag gaaacaatta   2400

ttgaagtaga gctgactaat atccagaaga aatactatcg ggctattttg gagaagaatt   2460

tctccttcct ttccaaaggg gcaggtcata ccaacatgcc taatctactt aacacaatga   2520

tggagttgcg caagtgctgc aaccacccat atctcatcaa tggtgctgaa gaaaaaatcc   2580

taacagaatt ccgtgaagct tgccatatta tacctcatga ctttcacctg caggccatgg   2640

ttcgttcagc cggcaaactg gttcttattg acaagttgct tccaaagctt aaagctggtg   2700

gccataaagt tctgatcttc tctcagatgg tacgctgcct agacatccta gaggattatt   2760

taatccagag gaggtactta tatgaacgta ttgatgggcg agttagaggc aaccttcgac   2820

aggctgccat tgaccgcttc agcaagcctg actcagaccg ctttgtcttc ttactgtgta   2880

cccgggctgg tggacttggt attaatctta cagctgctga tacctgcatc atctttgatt   2940

cagactggaa tccacaaaat gacctgcagg cccaggcacg atgtcatcga attgggcaga   3000

gcaaagctgt gaaggtgtac cgcctcatca ctcgtaattc ctacgagaga gagatgtttg   3060

ataaggccag cctcaagttg gggttggata aggctgtgct tcaatccatg agtggtcggg   3120

atggcaacat tactggaatc caacagttct ctaagaagga gattgaagat cttttaagaa   3180

aaggagcata tgcagccatc atggaggaag atgatgaagg ctccaagttt tgtgaagagg   3240

acattgacca gatcttgtta agacgaacta caaccatcac cattgaatct gaaggaaaag   3300

gttccacctt tgctaaggca agctttgttg cttctgaaaa caggacagat atttctttgg   3360

atgaccccaa cttttggcaa aagtgggcca aaaaggctga cctagacatg gatctgctca   3420

acagcaagaa taatttggta attgacacac ctagagtacg aaaacaaacg cgccacttta   3480

gcactctgaa agatgatgac ctggtggaat tctctgattt ggaaagtgag gatgatgagc   3540

ggccacgctc ccgcagacat gaccgtcatc atgcctatgg gcgcactgac tgctttcggg   3600

tggaaaagca tctcctggta tatggttggg gacgatggcg agatatttta tctcatggac   3660

gcttcaagcg acgtatgact gaacgagatg tggagaccat ttgtcgggcc attctcgtgt   3720

actgtcttct acactaccgt ggggatgaaa atattaaagg cttcatctgg gacttgatta   3780

gcccagctga aaatggcaag acaaaagaat tgcagaatca ttcaggtcta tctatccctg   3840

tgcctcgtgg acgcaaagga aaaaaagtaa agtcacaaag cacttttgat atccataagg   3900

cagattggat ccggaaatat aaccctgaca ctttgttcca agatgaaagt tataagaagc   3960

acttgaaaca tcagtgtaac aaggtactgt tgcgggtacg aatgctatac tacctgaggc   4020

aggaggttat tggagaccaa gcagaaaagg tgttaggggg tgcgattgcc agtgagattg   4080

acatatggtt cccagtagtg gatcaactgg aggttccaac aacttggtgg gacagtgagg   4140

ctgacaagtc gctgctcatt ggagtcttta aacatggcta tgagaaatat aataccatga   4200

gggcagaccc agccttatgt ttcctagaaa aggctggccg accagatgac aaagcaattg   4260

cagcagaaca tcgagtgttg gataacttct ctgacatagt agaaggggtt gactttgata   4320

aagattgtga agatcctgaa tataaaccac tccaaggtcc cccaaaggac caagatgatg   4380

agggtgatcc cttgatgatg atggatgagg agatctcagt gattgatgga gatgaagccc   4440

aggtgaccca acagccaggc catttattct ggcctccggg ctctgcccta acagctaggc   4500

ttcggcgtct agtaacagcg tatcagcgca gctacaagag agaacaaatg aagatagagg   4560

ctgcagaacg tggggaccgg cgaaggcggc gttgtgaagc agccttcaag ctgaaagaaa   4620

ttgcacggcg ggagaaacaa caacgatgga caaggcgtga acaaactgat ttttatcgag   4680

tggtgtctac gtttggtgtg gaatatgacc ctgacaccat gcagttccat tgggatcgct   4740

tccgcacttt tgctcgacta gacaaaaaga cagatgaaag ccttaccaag tacttccatg   4800

gctttgtggc catgtgccgc caagtatgcc gccttccccc agcagctgga gatgaacccc   4860

ccgaccctaa cctgttcatt gagcccatca ctgaggagag agcctcacgg actctctacc   4920

gtatagaatt gcttcggcgc ttacgggaac aagttttatg ccaccccctt ttggaagatc   4980

ggctggcatt gtgtcagcct cctggtcctg aattgcccaa atggtgggag cctgttcggc   5040

atgatgggga gcttctaaga ggggcagccc gccatggggt gagccaaaca gactgcaaca   5100

tcatgcagga cccagacttc tcttttctgg ctgcccgtat gaattatatg cagaaccatc   5160

aagcaggagc accagctcca tccttgtcac gctgctctac tccactgctg caccagcagt   5220

atacctcacg cactgcctca ccactgcccc tgcgcccaga tgctcctgtt gaaaagtcac   5280

ccgaggagac agctacccag gtccccagtc tggagagtct gactttaaag ctagagcacg   5340

aggtggtggc caggagccga ccaaccccac aagactatga gatgcgagta tccccctctg   5400

atactacccc tctggtttcc cggagtgttc caccagtcaa actggaggat gaggatgatt   5460

cggactctga gctggacttg agcaagctgt caccatcttc ttcttcttcc tcatcctcat   5520

ccagctccag ctccagcact gatgagagtg aggatgagaa ggaagagaag ctaactgacc   5580

agtcccgctc aaagctctat gatgaagaga gtctcctgtc cctcactatg tcccaagatg   5640

gattcccaaa tgaagatgga gaacaaatga cccctgagct tctgctactg caggaaagac   5700

aaagagcctc tgagtggccc aaggatcgtg tcctgataaa ccgtattgac ctcgtctgcc   5760

aggctgtact ctcagggaag tggccttcta gccgtaggag ccaggaaatg gtaacaggag   5820

gaattttggg gccaggcaac cacttgctag acagtccctc attgactcct ggagaatatg   5880

gtgactctcc agtccccaca ccacgaagta gtagtgcagc ttccatggca gaggaggaag   5940

catctgcagt cagcacagcg gcagcccagt tcaccaaact tcgccgaggc atggatgaaa   6000

aggagtttac agttcaaatc aaagatgagg aaggattgaa gttaacattc cagaagcaca   6060

agttgatggc gaatggagta atgggagatg gacatccact gtttcataag aagaagggga   6120

acagaaagaa gctagtagag ctggaggtgg agtgcatgga agagcctaat caccttgatg   6180

tggacctgga gacccggatc cctgtcatca ataaggtgga tggtactttg ctggtgggtg   6240

aggatgcccc tcgccgggct gaactggaga tgtggttaca gggtcatcca gagtttgctg   6300

ttgatccccg atttctagcg tatatggagg atcgcagaaa acagaagtgg caaagatgta   6360

aaaaaaataa taaggcagaa ttgaactgtt tgggaatgga accagtacag acagctaact   6420

ctagaaatgg gaaaaagggt catcacactg aaacggtgtt caaccgggtt ttgccagggc   6480

ctattgcacc agagagcagc aagaagcggg cccgtaggat gcgaccagac ctttctaaga   6540

tgatggccct catgcagggt ggaagcactg ggtctctatc tctgcataac acgttccaac   6600

acagcagtag tggcctacag tctgtgtcat ctttgggtca cagcagtgcc acttctgcat   6660

ctttgccttt tatgccattt gtgatgggtg gtgcacaatc atcccctcat gtagactcca   6720

gcaccatgct tcatcaccac caccaccacc cccaccccca ccatcaccac catcaccatc   6780

caggcttgag agcccctggc tacccctctt caccagtgac taccgcctct ggtactacct   6840

tgcggttgcc accactgcaa cctgaggagg atgacgatga ggatgaagaa gatgatgatg   6900

acttatctca gggctatgat agctcagaaa gggacttctc actcattgat gatcctatga   6960

tgccagctaa ctcagactcc agtgaagatg ctgatgactg aagccccagc atgggcccca   7020

ttgcttgggc ggctgctgta ttttcattta ctctggccct tggactatgg aaacgtggga   7080

ggggcagggg agatgtgggg aagtccagga ctccaggagg tgaaaaggaa aaaaaaaaaa   7140

aaaaaaa                                                             7147


<210>  3155
<211>  2302
<212>  PRT
<213>  Homosapiens

<400>  3155

Met Lys Gly Glu Ser Lys Arg Ile Thr Leu Val Leu Gln Gln Pro Gln 
1               5                   10                  15      


Ser Gly Gly Pro Gln Gly His Arg His Val Val Leu Gly Ser Leu Pro 
            20                  25                  30          


Gly Lys Ile Val Leu Gln Gly Asn Gln Leu Ala Ala Leu Thr Gln Ala 
        35                  40                  45              


Lys Asn Ala Gln Gly Gln Pro Ala Lys Val Val Thr Ile Gln Leu Gln 
    50                  55                  60                  


Val Gln Gln Pro Gln Gln Lys Ile Gln Ile Val Pro Gln Pro Pro Ser 
65                  70                  75                  80  


Ser Gln Pro Gln Pro Gln Gln Pro Pro Ser Thr Gln Pro Val Thr Leu 
                85                  90                  95      


Ser Ser Val Gln Gln Ala Gln Ile Met Gly Pro Gly Gln Ser Pro Gly 
            100                 105                 110         


Gln Arg Leu Ser Val Pro Val Lys Val Val Leu Gln Pro Gln Ala Gly 
        115                 120                 125             


Ser Ser Gln Gly Ala Ser Ser Gly Leu Ser Val Val Lys Val Leu Ser 
    130                 135                 140                 


Ala Ser Glu Val Ala Ala Leu Ser Ser Pro Ala Ser Ser Ala Pro His 
145                 150                 155                 160 


Ser Gly Gly Lys Thr Gly Met Glu Glu Asn Arg Arg Leu Glu His Gln 
                165                 170                 175     


Lys Lys Gln Glu Lys Ala Asn Arg Ile Val Ala Glu Ala Ile Ala Arg 
            180                 185                 190         


Ala Arg Ala Arg Gly Glu Gln Asn Ile Pro Arg Val Leu Asn Glu Asp 
        195                 200                 205             


Glu Leu Pro Ser Val Arg Pro Glu Glu Glu Gly Glu Lys Lys Arg Arg 
    210                 215                 220                 


Lys Lys Ser Ala Gly Glu Arg Leu Lys Glu Glu Lys Pro Lys Lys Ser 
225                 230                 235                 240 


Lys Thr Ser Gly Ala Ser Lys Thr Lys Gly Lys Ser Lys Leu Asn Thr 
                245                 250                 255     


Ile Thr Pro Val Val Gly Lys Lys Arg Lys Arg Asn Thr Ser Ser Asp 
            260                 265                 270         


Asn Ser Asp Val Glu Val Met Pro Ala Gln Ser Pro Arg Glu Asp Glu 
        275                 280                 285             


Glu Ser Ser Ile Gln Lys Arg Arg Ser Asn Arg Gln Val Lys Arg Lys 
    290                 295                 300                 


Lys Tyr Thr Glu Asp Leu Asp Ile Lys Ile Ala Asp Asp Glu Glu Glu 
305                 310                 315                 320 


Glu Glu Val Asp Val Thr Gly Pro Ile Lys Pro Glu Pro Ile Leu Pro 
                325                 330                 335     


Glu Pro Val Gln Glu Pro Asp Gly Glu Thr Leu Pro Ser Met Gln Phe 
            340                 345                 350         


Phe Val Glu Asn Pro Ser Glu Glu Asp Ala Ala Ile Val Asp Lys Val 
        355                 360                 365             


Leu Ser Met Arg Ile Val Lys Lys Glu Leu Pro Ser Gly Gln Tyr Thr 
    370                 375                 380                 


Glu Ala Glu Glu Phe Phe Val Lys Tyr Lys Asn Tyr Ser Tyr Leu His 
385                 390                 395                 400 


Cys Glu Trp Ala Thr Ile Ser Gln Leu Glu Lys Asp Lys Arg Ile His 
                405                 410                 415     


Gln Lys Leu Lys Arg Phe Lys Thr Lys Met Ala Gln Met Arg His Phe 
            420                 425                 430         


Phe His Glu Asp Glu Glu Pro Phe Asn Pro Asp Tyr Val Glu Val Asp 
        435                 440                 445             


Arg Ile Leu Asp Glu Ser His Ser Ile Asp Lys Asp Asn Gly Glu Pro 
    450                 455                 460                 


Val Ile Tyr Tyr Leu Val Lys Trp Cys Ser Leu Pro Tyr Glu Asp Ser 
465                 470                 475                 480 


Thr Trp Glu Leu Lys Glu Asp Val Asp Glu Gly Lys Ile Arg Glu Phe 
                485                 490                 495     


Lys Arg Ile Gln Ser Arg His Pro Glu Leu Lys Arg Val Asn Arg Pro 
            500                 505                 510         


Gln Ala Ser Ala Trp Lys Lys Leu Glu Leu Ser His Glu Tyr Lys Asn 
        515                 520                 525             


Arg Asn Gln Leu Arg Glu Tyr Gln Leu Glu Gly Val Asn Trp Leu Leu 
    530                 535                 540                 


Phe Asn Trp Tyr Asn Arg Gln Asn Cys Ile Leu Ala Asp Glu Met Gly 
545                 550                 555                 560 


Leu Gly Lys Thr Ile Gln Ser Ile Ala Phe Leu Gln Glu Val Tyr Asn 
                565                 570                 575     


Val Gly Ile His Gly Pro Phe Leu Val Ile Ala Pro Leu Ser Thr Ile 
            580                 585                 590         


Thr Asn Trp Glu Arg Glu Phe Asn Thr Trp Thr Glu Met Asn Thr Ile 
        595                 600                 605             


Val Tyr His Gly Ser Leu Ala Ser Arg Gln Met Ile Gln Gln Tyr Glu 
    610                 615                 620                 


Met Tyr Cys Lys Asp Ser Arg Gly Arg Leu Ile Pro Gly Ala Tyr Lys 
625                 630                 635                 640 


Phe Asp Ala Leu Ile Thr Thr Phe Glu Met Ile Leu Ser Asp Cys Pro 
                645                 650                 655     


Glu Leu Arg Glu Ile Glu Trp Arg Cys Val Ile Ile Asp Glu Ala His 
            660                 665                 670         


Arg Leu Lys Asn Arg Asn Cys Lys Leu Leu Asp Ser Leu Lys His Met 
        675                 680                 685             


Asp Leu Glu His Lys Val Leu Leu Thr Gly Thr Pro Leu Gln Asn Thr 
    690                 695                 700                 


Val Glu Glu Leu Phe Ser Leu Leu His Phe Leu Glu Pro Ser Gln Phe 
705                 710                 715                 720 


Pro Ser Glu Ser Glu Phe Leu Lys Asn Phe Gly Asp Leu Lys Thr Glu 
                725                 730                 735     


Glu Gln Val Gln Lys Leu Gln Ala Ile Leu Lys Pro Met Met Leu Arg 
            740                 745                 750         


Arg Leu Lys Glu Asp Val Glu Lys Asn Leu Ala Pro Lys Gln Glu Thr 
        755                 760                 765             


Ile Ile Glu Val Glu Leu Thr Asn Ile Gln Lys Lys Tyr Tyr Arg Ala 
    770                 775                 780                 


Ile Leu Glu Lys Asn Phe Ser Phe Leu Ser Lys Gly Ala Gly His Thr 
785                 790                 795                 800 


Asn Met Pro Asn Leu Leu Asn Thr Met Met Glu Leu Arg Lys Cys Cys 
                805                 810                 815     


Asn His Pro Tyr Leu Ile Asn Gly Ala Glu Glu Lys Ile Leu Thr Glu 
            820                 825                 830         


Phe Arg Glu Ala Cys His Ile Ile Pro His Asp Phe His Leu Gln Ala 
        835                 840                 845             


Met Val Arg Ser Ala Gly Lys Leu Val Leu Ile Asp Lys Leu Leu Pro 
    850                 855                 860                 


Lys Leu Lys Ala Gly Gly His Lys Val Leu Ile Phe Ser Gln Met Val 
865                 870                 875                 880 


Arg Cys Leu Asp Ile Leu Glu Asp Tyr Leu Ile Gln Arg Arg Tyr Leu 
                885                 890                 895     


Tyr Glu Arg Ile Asp Gly Arg Val Arg Gly Asn Leu Arg Gln Ala Ala 
            900                 905                 910         


Ile Asp Arg Phe Ser Lys Pro Asp Ser Asp Arg Phe Val Phe Leu Leu 
        915                 920                 925             


Cys Thr Arg Ala Gly Gly Leu Gly Ile Asn Leu Thr Ala Ala Asp Thr 
    930                 935                 940                 


Cys Ile Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala 
945                 950                 955                 960 


Gln Ala Arg Cys His Arg Ile Gly Gln Ser Lys Ala Val Lys Val Tyr 
                965                 970                 975     


Arg Leu Ile Thr Arg Asn Ser Tyr Glu Arg Glu Met Phe Asp Lys Ala 
            980                 985                 990         


Ser Leu Lys Leu Gly Leu Asp Lys  Ala Val Leu Gln Ser  Met Ser Gly 
        995                 1000                 1005             


Arg Asp  Gly Asn Ile Thr Gly  Ile Gln Gln Phe Ser  Lys Lys Glu 
    1010                 1015                 1020             


Ile Glu  Asp Leu Leu Arg Lys  Gly Ala Tyr Ala Ala  Ile Met Glu 
    1025                 1030                 1035             


Glu Asp  Asp Glu Gly Ser Lys  Phe Cys Glu Glu Asp  Ile Asp Gln 
    1040                 1045                 1050             


Ile Leu  Leu Arg Arg Thr Thr  Thr Ile Thr Ile Glu  Ser Glu Gly 
    1055                 1060                 1065             


Lys Gly  Ser Thr Phe Ala Lys  Ala Ser Phe Val Ala  Ser Glu Asn 
    1070                 1075                 1080             


Arg Thr  Asp Ile Ser Leu Asp  Asp Pro Asn Phe Trp  Gln Lys Trp 
    1085                 1090                 1095             


Ala Lys  Lys Ala Asp Leu Asp  Met Asp Leu Leu Asn  Ser Lys Asn 
    1100                 1105                 1110             


Asn Leu  Val Ile Asp Thr Pro  Arg Val Arg Lys Gln  Thr Arg His 
    1115                 1120                 1125             


Phe Ser  Thr Leu Lys Asp Asp  Asp Leu Val Glu Phe  Ser Asp Leu 
    1130                 1135                 1140             


Glu Ser  Glu Asp Asp Glu Arg  Pro Arg Ser Arg Arg  His Asp Arg 
    1145                 1150                 1155             


His His  Ala Tyr Gly Arg Thr  Asp Cys Phe Arg Val  Glu Lys His 
    1160                 1165                 1170             


Leu Leu  Val Tyr Gly Trp Gly  Arg Trp Arg Asp Ile  Leu Ser His 
    1175                 1180                 1185             


Gly Arg  Phe Lys Arg Arg Met  Thr Glu Arg Asp Val  Glu Thr Ile 
    1190                 1195                 1200             


Cys Arg  Ala Ile Leu Val Tyr  Cys Leu Leu His Tyr  Arg Gly Asp 
    1205                 1210                 1215             


Glu Asn  Ile Lys Gly Phe Ile  Trp Asp Leu Ile Ser  Pro Ala Glu 
    1220                 1225                 1230             


Asn Gly  Lys Thr Lys Glu Leu  Gln Asn His Ser Gly  Leu Ser Ile 
    1235                 1240                 1245             


Pro Val  Pro Arg Gly Arg Lys  Gly Lys Lys Val Lys  Ser Gln Ser 
    1250                 1255                 1260             


Thr Phe  Asp Ile His Lys Ala  Asp Trp Ile Arg Lys  Tyr Asn Pro 
    1265                 1270                 1275             


Asp Thr  Leu Phe Gln Asp Glu  Ser Tyr Lys Lys His  Leu Lys His 
    1280                 1285                 1290             


Gln Cys  Asn Lys Val Leu Leu  Arg Val Arg Met Leu  Tyr Tyr Leu 
    1295                 1300                 1305             


Arg Gln  Glu Val Ile Gly Asp  Gln Ala Glu Lys Val  Leu Gly Gly 
    1310                 1315                 1320             


Ala Ile  Ala Ser Glu Ile Asp  Ile Trp Phe Pro Val  Val Asp Gln 
    1325                 1330                 1335             


Leu Glu  Val Pro Thr Thr Trp  Trp Asp Ser Glu Ala  Asp Lys Ser 
    1340                 1345                 1350             


Leu Leu  Ile Gly Val Phe Lys  His Gly Tyr Glu Lys  Tyr Asn Thr 
    1355                 1360                 1365             


Met Arg  Ala Asp Pro Ala Leu  Cys Phe Leu Glu Lys  Ala Gly Arg 
    1370                 1375                 1380             


Pro Asp  Asp Lys Ala Ile Ala  Ala Glu His Arg Val  Leu Asp Asn 
    1385                 1390                 1395             


Phe Ser  Asp Ile Val Glu Gly  Val Asp Phe Asp Lys  Asp Cys Glu 
    1400                 1405                 1410             


Asp Pro  Glu Tyr Lys Pro Leu  Gln Gly Pro Pro Lys  Asp Gln Asp 
    1415                 1420                 1425             


Asp Glu  Gly Asp Pro Leu Met  Met Met Asp Glu Glu  Ile Ser Val 
    1430                 1435                 1440             


Ile Asp  Gly Asp Glu Ala Gln  Val Thr Gln Gln Pro  Gly His Leu 
    1445                 1450                 1455             


Phe Trp  Pro Pro Gly Ser Ala  Leu Thr Ala Arg Leu  Arg Arg Leu 
    1460                 1465                 1470             


Val Thr  Ala Tyr Gln Arg Ser  Tyr Lys Arg Glu Gln  Met Lys Ile 
    1475                 1480                 1485             


Glu Ala  Ala Glu Arg Gly Asp  Arg Arg Arg Arg Arg  Cys Glu Ala 
    1490                 1495                 1500             


Ala Phe  Lys Leu Lys Glu Ile  Ala Arg Arg Glu Lys  Gln Gln Arg 
    1505                 1510                 1515             


Trp Thr  Arg Arg Glu Gln Thr  Asp Phe Tyr Arg Val  Val Ser Thr 
    1520                 1525                 1530             


Phe Gly  Val Glu Tyr Asp Pro  Asp Thr Met Gln Phe  His Trp Asp 
    1535                 1540                 1545             


Arg Phe  Arg Thr Phe Ala Arg  Leu Asp Lys Lys Thr  Asp Glu Ser 
    1550                 1555                 1560             


Leu Thr  Lys Tyr Phe His Gly  Phe Val Ala Met Cys  Arg Gln Val 
    1565                 1570                 1575             


Cys Arg  Leu Pro Pro Ala Ala  Gly Asp Glu Pro Pro  Asp Pro Asn 
    1580                 1585                 1590             


Leu Phe  Ile Glu Pro Ile Thr  Glu Glu Arg Ala Ser  Arg Thr Leu 
    1595                 1600                 1605             


Tyr Arg  Ile Glu Leu Leu Arg  Arg Leu Arg Glu Gln  Val Leu Cys 
    1610                 1615                 1620             


His Pro  Leu Leu Glu Asp Arg  Leu Ala Leu Cys Gln  Pro Pro Gly 
    1625                 1630                 1635             


Pro Glu  Leu Pro Lys Trp Trp  Glu Pro Val Arg His  Asp Gly Glu 
    1640                 1645                 1650             


Leu Leu  Arg Gly Ala Ala Arg  His Gly Val Ser Gln  Thr Asp Cys 
    1655                 1660                 1665             


Asn Ile  Met Gln Asp Pro Asp  Phe Ser Phe Leu Ala  Ala Arg Met 
    1670                 1675                 1680             


Asn Tyr  Met Gln Asn His Gln  Ala Gly Ala Pro Ala  Pro Ser Leu 
    1685                 1690                 1695             


Ser Arg  Cys Ser Thr Pro Leu  Leu His Gln Gln Tyr  Thr Ser Arg 
    1700                 1705                 1710             


Thr Ala  Ser Pro Leu Pro Leu  Arg Pro Asp Ala Pro  Val Glu Lys 
    1715                 1720                 1725             


Ser Pro  Glu Glu Thr Ala Thr  Gln Val Pro Ser Leu  Glu Ser Leu 
    1730                 1735                 1740             


Thr Leu  Lys Leu Glu His Glu  Val Val Ala Arg Ser  Arg Pro Thr 
    1745                 1750                 1755             


Pro Gln  Asp Tyr Glu Met Arg  Val Ser Pro Ser Asp  Thr Thr Pro 
    1760                 1765                 1770             


Leu Val  Ser Arg Ser Val Pro  Pro Val Lys Leu Glu  Asp Glu Asp 
    1775                 1780                 1785             


Asp Ser  Asp Ser Glu Leu Asp  Leu Ser Lys Leu Ser  Pro Ser Ser 
    1790                 1795                 1800             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser Ser Ser  Thr Asp Glu 
    1805                 1810                 1815             


Ser Glu  Asp Glu Lys Glu Glu  Lys Leu Thr Asp Gln  Ser Arg Ser 
    1820                 1825                 1830             


Lys Leu  Tyr Asp Glu Glu Ser  Leu Leu Ser Leu Thr  Met Ser Gln 
    1835                 1840                 1845             


Asp Gly  Phe Pro Asn Glu Asp  Gly Glu Gln Met Thr  Pro Glu Leu 
    1850                 1855                 1860             


Leu Leu  Leu Gln Glu Arg Gln  Arg Ala Ser Glu Trp  Pro Lys Asp 
    1865                 1870                 1875             


Arg Val  Leu Ile Asn Arg Ile  Asp Leu Val Cys Gln  Ala Val Leu 
    1880                 1885                 1890             


Ser Gly  Lys Trp Pro Ser Ser  Arg Arg Ser Gln Glu  Met Val Thr 
    1895                 1900                 1905             


Gly Gly  Ile Leu Gly Pro Gly  Asn His Leu Leu Asp  Ser Pro Ser 
    1910                 1915                 1920             


Leu Thr  Pro Gly Glu Tyr Gly  Asp Ser Pro Val Pro  Thr Pro Arg 
    1925                 1930                 1935             


Ser Ser  Ser Ala Ala Ser Met  Ala Glu Glu Glu Ala  Ser Ala Val 
    1940                 1945                 1950             


Ser Thr  Ala Ala Ala Gln Phe  Thr Lys Leu Arg Arg  Gly Met Asp 
    1955                 1960                 1965             


Glu Lys  Glu Phe Thr Val Gln  Ile Lys Asp Glu Glu  Gly Leu Lys 
    1970                 1975                 1980             


Leu Thr  Phe Gln Lys His Lys  Leu Met Ala Asn Gly  Val Met Gly 
    1985                 1990                 1995             


Asp Gly  His Pro Leu Phe His  Lys Lys Lys Gly Asn  Arg Lys Lys 
    2000                 2005                 2010             


Leu Val  Glu Leu Glu Val Glu  Cys Met Glu Glu Pro  Asn His Leu 
    2015                 2020                 2025             


Asp Val  Asp Leu Glu Thr Arg  Ile Pro Val Ile Asn  Lys Val Asp 
    2030                 2035                 2040             


Gly Thr  Leu Leu Val Gly Glu  Asp Ala Pro Arg Arg  Ala Glu Leu 
    2045                 2050                 2055             


Glu Met  Trp Leu Gln Gly His  Pro Glu Phe Ala Val  Asp Pro Arg 
    2060                 2065                 2070             


Phe Leu  Ala Tyr Met Glu Asp  Arg Arg Lys Gln Lys  Trp Gln Arg 
    2075                 2080                 2085             


Cys Lys  Lys Asn Asn Lys Ala  Glu Leu Asn Cys Leu  Gly Met Glu 
    2090                 2095                 2100             


Pro Val  Gln Thr Ala Asn Ser  Arg Asn Gly Lys Lys  Gly His His 
    2105                 2110                 2115             


Thr Glu  Thr Val Phe Asn Arg  Val Leu Pro Gly Pro  Ile Ala Pro 
    2120                 2125                 2130             


Glu Ser  Ser Lys Lys Arg Ala  Arg Arg Met Arg Pro  Asp Leu Ser 
    2135                 2140                 2145             


Lys Met  Met Ala Leu Met Gln  Gly Gly Ser Thr Gly  Ser Leu Ser 
    2150                 2155                 2160             


Leu His  Asn Thr Phe Gln His  Ser Ser Ser Gly Leu  Gln Ser Val 
    2165                 2170                 2175             


Ser Ser  Leu Gly His Ser Ser  Ala Thr Ser Ala Ser  Leu Pro Phe 
    2180                 2185                 2190             


Met Pro  Phe Val Met Gly Gly  Ala Gln Ser Ser Pro  His Val Asp 
    2195                 2200                 2205             


Ser Ser  Thr Met Leu His His  His His His His Pro  His Pro His 
    2210                 2215                 2220             


His His  His His His His Pro  Gly Leu Arg Ala Pro  Gly Tyr Pro 
    2225                 2230                 2235             


Ser Ser  Pro Val Thr Thr Ala  Ser Gly Thr Thr Leu  Arg Leu Pro 
    2240                 2245                 2250             


Pro Leu  Gln Pro Glu Glu Asp  Asp Asp Glu Asp Glu  Glu Asp Asp 
    2255                 2260                 2265             


Asp Asp  Leu Ser Gln Gly Tyr  Asp Ser Ser Glu Arg  Asp Phe Ser 
    2270                 2275                 2280             


Leu Ile  Asp Asp Pro Met Met  Pro Ala Asn Ser Asp  Ser Ser Glu 
    2285                 2290                 2295             


Asp Ala  Asp Asp 
    2300         


<210>  3156
<211>  2335
<212>  DNA
<213>  Homosapiens

<400>  3156
gaagaagatc ggtagattga gtggctagag aggtcggagg taagtggcta tagaagtcgg     60

gcggacccgg aacccagagg acgcgacacc atgacttatg cttatctctt caagtatatc    120

atcatcggag acacaggtgt ggggaagtca tgtctcctcc tgcagtttac agataagcgg    180

ttccagcctg tccacgacct cacaataggt gtggagtttg gagctcgtat ggtcaacatt    240

gatggaaaac aaatcaaact gcaaatctgg gatacggctg ggcaagaatc cttccgttct    300

atcacccgtt cctactacag gggagcagct ggagcactgc tggtgtacga cattacaagg    360

cgtgaaacct tcaaccacct gacctcatgg ttagaggatg cccggcagca ctctagttcc    420

aacatggtta tcatgctcat tgggaataag agtgacctag agtcccgcag ggatgtgaag    480

agagaagaag gagaggcctt tgctagggag catggactta tattcatgga aacttcagcc    540

aaaacagcct gcaatgttga agaggccttc attaacacag ccaaagaaat atataggaag    600

atccagcagg gtttatttga tgtccacaat gaggcaaatg gcatcaagat tgggccccaa    660

cagtcaattt caacatcagt gggacccagt gcctcccagc ggaactctcg tgacataggg    720

tccaactctg gctgctgctg aacatctggc ttgaactttt tttgtccttc ctggaatagc    780

ttcagatcaa taggcttaat gaaagaggtc tttcttgctt tggctgagag cagcctcttt    840

ttaaagtgtg atgttttgcc tttccaccta aagaccagga gagaatttgg gcccttactg    900

acctgtcctc cttcagggac atgagcattc cctatagatt agggttcttc ttatcctcct    960

atacaaattt cttaaattgt taggaccaaa gtgctggatt acaggcgtga gccaccgtgc   1020

ctggcctaaa taaataattt cgtaagcata tacaatccac ttcccactaa gaattagggt   1080

caaagacatt ctgcttgaac acttgcagtt acctagatct agttggcctt tggttgatag   1140

atcctctgcc tcagaatttc attgagtttt tttcttcctt gcctttgggt gtctgcttgc   1200

cacttcctaa gaattcttgt agaaggcagt ttcctctact tgcccaagag cactgagtac   1260

ttctctacta tcctattatt agcttctatc tcttagtgta acttcaaaac ttttaagagc   1320

agtgaagttg gtcagggaca tgtggccact tattattacc taaagaaaac atttgttccc   1380

tgttcatttt attttagggg ccagatctaa cattgtagtg tctttcacca gatagacttc   1440

tactgtttca tcaaactccc ttcttaacta gacctagact ttctactcca atcaggctaa   1500

tctacttact gaatgtgaca tatttattcc tagttccata cctttgcaca tgccctactc   1560

tccactaatt atacttaaaa gtccaaaaat tttttcttta gtaacagact taggtactgc   1620

taagcagtta ttaacacaat attccttagt tttcatatgt tggttattca tatgtctatt   1680

tatatgtata tttattttta tgtatgttac tatgtaaata tggtttgcag ttgtttttgt   1740

gtggaatctt gtctttccgt ataagttgta agctccttga gagcaggatc catgtcattc   1800

ctttattttt ataaattatt ccccctatca ttcctttaca gtgcctagtg ctgctcatta   1860

tgtgttcatt gaatttgact gacatagtta aaaacttaag gtttatttta gactttcaag   1920

gaaacaaaag actttagagt cctctctctg taattctgcc ccactcattt gtttaccctg   1980

ggttttatac atttctcttc cttctcccct cccacctttc cctggctttt tgcctccatt   2040

ccatgaggca tacagtaagg ctgcctgcta gtaagcagtc acataagtgg gtacctatcc   2100

agccattctc ttttcagagc atataatact atcttagcca aacttgcctt tgcttcactc   2160

atcatgcagc cttctgggtt ggttgctata tatatctttt ttccttgatg tcccattctc   2220

ttccacagcc ctgaggtctt acgaattttt ctactttctt tttgctgttg atgaattgtt   2280

tcattattaa atatatgcat gtaccaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa        2335


<210>  3157
<211>  216
<212>  PRT
<213>  Homosapiens

<400>  3157

Met Thr Tyr Ala Tyr Leu Phe Lys Tyr Ile Ile Ile Gly Asp Thr Gly 
1               5                   10                  15      


Val Gly Lys Ser Cys Leu Leu Leu Gln Phe Thr Asp Lys Arg Phe Gln 
            20                  25                  30          


Pro Val His Asp Leu Thr Ile Gly Val Glu Phe Gly Ala Arg Met Val 
        35                  40                  45              


Asn Ile Asp Gly Lys Gln Ile Lys Leu Gln Ile Trp Asp Thr Ala Gly 
    50                  55                  60                  


Gln Glu Ser Phe Arg Ser Ile Thr Arg Ser Tyr Tyr Arg Gly Ala Ala 
65                  70                  75                  80  


Gly Ala Leu Leu Val Tyr Asp Ile Thr Arg Arg Glu Thr Phe Asn His 
                85                  90                  95      


Leu Thr Ser Trp Leu Glu Asp Ala Arg Gln His Ser Ser Ser Asn Met 
            100                 105                 110         


Val Ile Met Leu Ile Gly Asn Lys Ser Asp Leu Glu Ser Arg Arg Asp 
        115                 120                 125             


Val Lys Arg Glu Glu Gly Glu Ala Phe Ala Arg Glu His Gly Leu Ile 
    130                 135                 140                 


Phe Met Glu Thr Ser Ala Lys Thr Ala Cys Asn Val Glu Glu Ala Phe 
145                 150                 155                 160 


Ile Asn Thr Ala Lys Glu Ile Tyr Arg Lys Ile Gln Gln Gly Leu Phe 
                165                 170                 175     


Asp Val His Asn Glu Ala Asn Gly Ile Lys Ile Gly Pro Gln Gln Ser 
            180                 185                 190         


Ile Ser Thr Ser Val Gly Pro Ser Ala Ser Gln Arg Asn Ser Arg Asp 
        195                 200                 205             


Ile Gly Ser Asn Ser Gly Cys Cys 
    210                 215     


<210>  3158
<211>  4538
<212>  DNA
<213>  Homosapiens

<400>  3158
agcagagaga acacacgtcc ttgcggaagt gacggcagtt ccgagtccag tgggggcggt     60

gggagcgatg agggtctgag acggtgggag cggttgtgtg aagatggagt ttcccggagg    120

aaatgacaat tacctgacga tcacagggcc ttcgcacccc ttcctgtcag gggccgagac    180

attccataca ccaagcttgg gtgatgagga atttgaaatc ccacctatct ccttggattc    240

tgatccctca ttggctgtct cagatgtggt tggccacttt gatgacctgg cagacccttc    300

ctcttcacag gatggcagtt tttcagccca gtatggggtc cagacattgg acatgcctgt    360

gggcatgacc catggcttga tggagcaggg cggggggctc ctgagtgggg gcttgaccat    420

ggacttggac cactctatag gaactcagta tagtgccaac ccacctgtta caattgatgt    480

accaatgaca gacatgacat ctggcttgat ggggcatagc cagttgacca ccattgatca    540

gtcagaactg agttcccagc tgggtttgag cctagggggt ggcaccatcc tgccacctgc    600

ccagtcacct gaagatcgtc tttcaaccac cccttcacct actagttcac ttcacgagga    660

tggtgttgag gatttccgga ggcaacttcc cagccagaag acagtcgtgg tggaagcagg    720

gaaaaagcag aaggccccaa agaagagaaa aaagaaagat cctaatgaac ctcagaaacc    780

agtttcagca tatgctttat tctttcgtga tacacaggct gccatcaagg gacagaatcc    840

taatgccact tttggtgagg tttcaaaaat tgtggcctcc atgtgggata gtcttggaga    900

ggagcaaaaa caggtatata agaggaaaac tgaggctgcc aagaaagagt atctgaaggc    960

actggctgct tacaaagaca accaggagtg tcaggccact gtggaaacag tggaattgga   1020

tccagcacca ccatcacaaa ctccttctcc acctcctatg gctactgttg acccagcatc   1080

tccagcacca gcttcaatag agccccctgc cctgtcccca tccattgttg ttaactccac   1140

cctttcatcc tatgtggcaa accaggcatc ttctggagct gggggtcagc ccaatatcac   1200

caagttgatt attaccaaac aaatgttgcc ctcttctatt actatgtctc aaggagggat   1260

ggttactgtt atcccagcca cagtggtgac ctcccggggg ctccaactag gccaaaccag   1320

tacagctact atccagccca gtcaacaagc ccagattgtc actcggtcag tgttgcaggc   1380

agcagcagct gctgctgctg ctgcttctat gcaactgcct ccaccccgac tacagccccc   1440

tccattacaa cagatgccac agcccccgac tcagcagcaa gttaccattc tgcagcagcc   1500

tcctccactc caggccatgc aacagcctcc acctcagaaa gttcgaatca atttacagca   1560

acagcctcct cctctgcaga tcaagagtgt gcctctaccc actttgaaaa tgcagactac   1620

cttagtccca ccaactgtgg aaagtagtcc tgagcggcct atgaacaaca gccctgaggc   1680

ccatacagtg gaggcacctt ctcctgagac tatctgtgag atgatcacag atgtagttcc   1740

tgaggttgag tctccttctc agatggatgt tgaattggtg agtgggtctc ctgtggcact   1800

ctcaccccag cctcgatgtg tgaggtctgg ttgtgagaac cctcccattg tgagtaagga   1860

ctgggacaat gaatactgca gcaatgagtg tgtggtgaag cactgcaggg atgtattctt   1920

ggcctgggta gcctctagaa attcaaacac agtggtgttt gtgaaatagt ccttcctgtt   1980

ctccaagcca gtgaagagtt atctgctggg aaagtgtcca agagcctgtt tttgaaacac   2040

aagctgggct tctggtagtg cctcatcaca acccatgatg gctgttcatg tttcacccct   2100

tttcttcctt cagcagaggc caggctatgg agcagggcca ctgaatttgc tgtaatctgg   2160

agatgctttt tactttcaac cataagcggt aatagcagag gaaagggtga agggagtctg   2220

ggcaagcaaa gcatagagat ggtggggtgg tggtggggtt gaagaaactt gttggtataa   2280

ttgtcatagg acttgcctaa aatattatta aaattacggg agtgtactca gctttgagcc   2340

taggagaaaa tgccactgtg tgcatccatt ttaaagggtt ccctcataaa aaaatgttat   2400

tccccattat cacatcagta cactgctttg aaaacaaaac ttttcaacat gggcatactg   2460

ggctacatgg aaaatgacat cacccaggag tgatttctct ttatatatat tatttctgca   2520

gttaccatcc ttatctgagt tatcacagtt catgaatcta agaggcggaa ctctacatca   2580

ttagtaagag gttccaccaa agtctaaagt tgtattcact tgtgtttgat gaactatctt   2640

taaaagacca taggtctatc attatttctt agacataatc taaagaaaaa cagactagag   2700

aagccacctg gttgtaacag aataagcaga agtttacagc atgatagtcc aagtggtgat   2760

aactttaaat aaaactcaaa tttttactgt ttgtagacag gaatgctgtc ctagagaacc   2820

tcctcctcaa ccagctacgt acatagtttt atcctatgca ttcctgtttt ctgtgttttt   2880

tgtttttttt ttttgagaca gagtctcgct ctgtcaccca ggctggagtg cagtggtgcg   2940

acctcagctc actgaaacct ctgcctcccg ggttcaagcg attctcctgc atcagcctcc   3000

cgagtagcta ggattacagg cgcccgccac tacgcccagc taatttgtgg tatttttagt   3060

agagacaggg tttcaccatg ttggccaggc tggtctcgaa ctcctgacct catgatccgc   3120

ccgccttgac ctcccaaagt gctgggatta caggcatgag ccaccgcacc cagcctgcat   3180

tcctgttttt ttaatggttt tggagggtag cagtagagat ggggtctcac tatgttgccc   3240

agtctagtct tgaactcctg ggctacagtt accctcctac ctcggcttcc caaagtgctc   3300

ggattacagg tgtgagccac tgtgcctagc ctataatgat cattttaatg tttcccatgc   3360

actcatttag tttgaacctt cacagcaacc caatgaggta atactcccat ttcacatata   3420

atactgagag atgagttgca caagattata cactgttaag tagcagagcc agaatggact   3480

tcagaatccc aactacaata caaatgttta tttaaataaa gaagaaagct attgtacaaa   3540

tatcactctt caggtttagc ttacagagcc atggctatgg attcttagct ctgtaaggaa   3600

gtgcttctat aaattcttag gtttagagat gataccatct gggtaccttt gcttgaaccg   3660

tgcaaccaca tctgggtcta gtaggtggat cccatccagt tggtttccaa gggtgatcct   3720

gaaacagtgt aaaaggaggg gcaaaccaga aatcctggaa ttagagggtt taatattgtt   3780

aaaaaatgca taccaaatga agactgccta tcatcatatc aaatatgcca attctaaaaa   3840

gagcttaaca ttagaatagt atatggtaga attactagtt cagaattggc atagattctg   3900

gtgttaaaat agactggatc tgtattatct gagggttagt aactaatgct tagccaggcc   3960

tgcttcacag agttgctacc agggagtatt ctttggataa gcaaaatgct agcagcatgt   4020

gttttaagct ctgttaaggg gtgaaagatg taattattga cagattaaat agataacttc   4080

gtaaccacca gggggcagat tcaatacatc acagaatggc tgaggaagat ccttgggttg   4140

tgaagagagt agaaacccta gggagcagtg cttttgggtc ctagaacctg ttgagtttct   4200

aatgaatatt tgtagaatct cataaaacag tttaaataca agcttaagtg gcttatgaat   4260

cctgtgaagc tcatttatgg actagtgtaa aacaatgtga agctctacta agttctgtcc   4320

ttaatcataa ataatagccc cttgaggact agcctgttct ctggtcacct taccagttgg   4380

gttgcacatt gtgtggtcgt ccaaataact caatcttgcg agtgccagga gatagtcttt   4440

caatcatgcc atagatttca tctggtttat gactggtgga acgaacctag gaaataaaaa   4500

ctagctgctt tttaagttac acaaaaaaaa aaaaaaaa                           4538


<210>  3159
<211>  621
<212>  PRT
<213>  Homosapiens

<400>  3159

Met Glu Phe Pro Gly Gly Asn Asp Asn Tyr Leu Thr Ile Thr Gly Pro 
1               5                   10                  15      


Ser His Pro Phe Leu Ser Gly Ala Glu Thr Phe His Thr Pro Ser Leu 
            20                  25                  30          


Gly Asp Glu Glu Phe Glu Ile Pro Pro Ile Ser Leu Asp Ser Asp Pro 
        35                  40                  45              


Ser Leu Ala Val Ser Asp Val Val Gly His Phe Asp Asp Leu Ala Asp 
    50                  55                  60                  


Pro Ser Ser Ser Gln Asp Gly Ser Phe Ser Ala Gln Tyr Gly Val Gln 
65                  70                  75                  80  


Thr Leu Asp Met Pro Val Gly Met Thr His Gly Leu Met Glu Gln Gly 
                85                  90                  95      


Gly Gly Leu Leu Ser Gly Gly Leu Thr Met Asp Leu Asp His Ser Ile 
            100                 105                 110         


Gly Thr Gln Tyr Ser Ala Asn Pro Pro Val Thr Ile Asp Val Pro Met 
        115                 120                 125             


Thr Asp Met Thr Ser Gly Leu Met Gly His Ser Gln Leu Thr Thr Ile 
    130                 135                 140                 


Asp Gln Ser Glu Leu Ser Ser Gln Leu Gly Leu Ser Leu Gly Gly Gly 
145                 150                 155                 160 


Thr Ile Leu Pro Pro Ala Gln Ser Pro Glu Asp Arg Leu Ser Thr Thr 
                165                 170                 175     


Pro Ser Pro Thr Ser Ser Leu His Glu Asp Gly Val Glu Asp Phe Arg 
            180                 185                 190         


Arg Gln Leu Pro Ser Gln Lys Thr Val Val Val Glu Ala Gly Lys Lys 
        195                 200                 205             


Gln Lys Ala Pro Lys Lys Arg Lys Lys Lys Asp Pro Asn Glu Pro Gln 
    210                 215                 220                 


Lys Pro Val Ser Ala Tyr Ala Leu Phe Phe Arg Asp Thr Gln Ala Ala 
225                 230                 235                 240 


Ile Lys Gly Gln Asn Pro Asn Ala Thr Phe Gly Glu Val Ser Lys Ile 
                245                 250                 255     


Val Ala Ser Met Trp Asp Ser Leu Gly Glu Glu Gln Lys Gln Val Tyr 
            260                 265                 270         


Lys Arg Lys Thr Glu Ala Ala Lys Lys Glu Tyr Leu Lys Ala Leu Ala 
        275                 280                 285             


Ala Tyr Lys Asp Asn Gln Glu Cys Gln Ala Thr Val Glu Thr Val Glu 
    290                 295                 300                 


Leu Asp Pro Ala Pro Pro Ser Gln Thr Pro Ser Pro Pro Pro Met Ala 
305                 310                 315                 320 


Thr Val Asp Pro Ala Ser Pro Ala Pro Ala Ser Ile Glu Pro Pro Ala 
                325                 330                 335     


Leu Ser Pro Ser Ile Val Val Asn Ser Thr Leu Ser Ser Tyr Val Ala 
            340                 345                 350         


Asn Gln Ala Ser Ser Gly Ala Gly Gly Gln Pro Asn Ile Thr Lys Leu 
        355                 360                 365             


Ile Ile Thr Lys Gln Met Leu Pro Ser Ser Ile Thr Met Ser Gln Gly 
    370                 375                 380                 


Gly Met Val Thr Val Ile Pro Ala Thr Val Val Thr Ser Arg Gly Leu 
385                 390                 395                 400 


Gln Leu Gly Gln Thr Ser Thr Ala Thr Ile Gln Pro Ser Gln Gln Ala 
                405                 410                 415     


Gln Ile Val Thr Arg Ser Val Leu Gln Ala Ala Ala Ala Ala Ala Ala 
            420                 425                 430         


Ala Ala Ser Met Gln Leu Pro Pro Pro Arg Leu Gln Pro Pro Pro Leu 
        435                 440                 445             


Gln Gln Met Pro Gln Pro Pro Thr Gln Gln Gln Val Thr Ile Leu Gln 
    450                 455                 460                 


Gln Pro Pro Pro Leu Gln Ala Met Gln Gln Pro Pro Pro Gln Lys Val 
465                 470                 475                 480 


Arg Ile Asn Leu Gln Gln Gln Pro Pro Pro Leu Gln Ile Lys Ser Val 
                485                 490                 495     


Pro Leu Pro Thr Leu Lys Met Gln Thr Thr Leu Val Pro Pro Thr Val 
            500                 505                 510         


Glu Ser Ser Pro Glu Arg Pro Met Asn Asn Ser Pro Glu Ala His Thr 
        515                 520                 525             


Val Glu Ala Pro Ser Pro Glu Thr Ile Cys Glu Met Ile Thr Asp Val 
    530                 535                 540                 


Val Pro Glu Val Glu Ser Pro Ser Gln Met Asp Val Glu Leu Val Ser 
545                 550                 555                 560 


Gly Ser Pro Val Ala Leu Ser Pro Gln Pro Arg Cys Val Arg Ser Gly 
                565                 570                 575     


Cys Glu Asn Pro Pro Ile Val Ser Lys Asp Trp Asp Asn Glu Tyr Cys 
            580                 585                 590         


Ser Asn Glu Cys Val Val Lys His Cys Arg Asp Val Phe Leu Ala Trp 
        595                 600                 605             


Val Ala Ser Arg Asn Ser Asn Thr Val Val Phe Val Lys 
    610                 615                 620     


<210>  3160
<211>  699
<212>  DNA
<213>  Homosapiens

<400>  3160
catccggtgt ggtcgacggg tcctccaaga gtttggggcg cggaccggag taccttgcgt     60

gcagttatgt cggcgtcggt agtgtctgtc atttcgcggt tcttagaaga gtacttgagc    120

tccactccgc agcgtctgaa gttgctggac gcgtacctgc tgtatatact gctgaccggg    180

gcgctgcagt tcggttactg tctcctcgtg gggaccttcc ccttcaactc ttttctctcg    240

ggcttcatct cttgtgtggg gagtttcatc ctagcggttt gcctgagaat acagatcaac    300

ccacagaaca aagcggattt ccaaggcatc tccccagagc gagcctttgc tgattttctc    360

tttgccagca ccatcctgca ccttgttgtc atgaactttg ttggctgaat cattctcatt    420

tacttaattg aggagtagga gactaaaaga atgttcactc tttgaatttc ctggataaga    480

gttctggaga tggcagctta ttggacacat ggattttctt cagatttgac acttactgct    540

agctctgctt tttatgacag gagaaaagcc cagagttcac tgtgtgtcag aacaactttc    600

taacaaacat ttattaatcc agcctctgcc tttcattaaa tgtaaccttt tgctttccaa    660

attaaagaac tccatgccac tcctcaaaaa aaaaaaaaa                           699


<210>  3161
<211>  113
<212>  PRT
<213>  Homosapiens

<400>  3161

Met Ser Ala Ser Val Val Ser Val Ile Ser Arg Phe Leu Glu Glu Tyr 
1               5                   10                  15      


Leu Ser Ser Thr Pro Gln Arg Leu Lys Leu Leu Asp Ala Tyr Leu Leu 
            20                  25                  30          


Tyr Ile Leu Leu Thr Gly Ala Leu Gln Phe Gly Tyr Cys Leu Leu Val 
        35                  40                  45              


Gly Thr Phe Pro Phe Asn Ser Phe Leu Ser Gly Phe Ile Ser Cys Val 
    50                  55                  60                  


Gly Ser Phe Ile Leu Ala Val Cys Leu Arg Ile Gln Ile Asn Pro Gln 
65                  70                  75                  80  


Asn Lys Ala Asp Phe Gln Gly Ile Ser Pro Glu Arg Ala Phe Ala Asp 
                85                  90                  95      


Phe Leu Phe Ala Ser Thr Ile Leu His Leu Val Val Met Asn Phe Val 
            100                 105                 110         


Gly 
    


<210>  3162
<211>  2543
<212>  DNA
<213>  Homosapiens

<400>  3162
tcccgggtca gctggtgctg gcgtcaggcg ctgggcgggc tcgccaggac ctggcaaggc     60

ttgtttacta tggccgatga tctggagcag cagtctcaag gctggctgag tagctggctg    120

cccacgtggc gccccacttc catgtctcag ctgaagaatg tggaagccag gatcctccag    180

tgtctccaga ataagttcct ggccagatat gtatccctcc caaaccagaa taagatctgg    240

acggtgactg tgagccccga gcaaaacgac cgcaccccct tggtgatggt gcatggtttt    300

gggggcggcg tgggtctctg gatcctcaac atggactcac tgagtgcccg ccgcacactg    360

cacaccttcg atctgcttgg cttcgggcga agctcaaggc cagcattccc aagggacccg    420

gagggggctg aggatgagtt tgtgacatcg atagagacat ggcgggagac catggggatc    480

cccagcatga tcctcctggg gcacagtttg ggaggattcc tggccacttc ttactcaatc    540

aagtaccctg atagagttaa acacctcatc ctggtggacc catggggctt tcccctccga    600

ccaactaacc ccagtgagat ccgtgcaccc ccagcctggg tcaaagccgt ggcatctgtc    660

ctaggacgtt ccaatccatt ggctgttctt cgagtagctg ggccctgggg gcctggtctg    720

gtgcagcgat tccggccgga cttcaaacgc aagtttgcag acttctttga agatgatacc    780

atatcagagt atatttacca ctgcaacgca cagaatccca gtggtgagac agcattcaaa    840

gccatgatgg agtcctttgg ctgggcccgg cgccctatgc tggagcgaat tcacttgatt    900

cgaaaagatg tgcctatcac tatgatctac gggtccgaca cctggataga taccagtacg    960

ggaaaaaagg tgaagatgca gcggccggat tcctatgtcc gagacatgga gattaagggt   1020

gcctcccacc atgtctatgc tgaccagcca cacatcttca atgctgtggt ggaggagatc   1080

tgcgactcag ttgattgagc tgctctctga agaggaagag gagaaagcca gagagtcact   1140

cttacctccc tgtctgctta ctcacccact ctgtcctttc ctcaccaact aacatgtgcc   1200

agccaggcag agtcttgtgc tgttcccaga acaggacgac agtgaaaaga acactcttga   1260

ccctacactg aaggctgaag gcagaagcca caagaggcct tgagtgccac ccccagggaa   1320

gaacataaag ggttgcacaa tgccacccat ccactccttg ccaagtgtta cccagatggt   1380

ggaggatgtg aagggattgc accaagccac attcactctc tctgtggcct ttcttcctct   1440

gggcaaagaa gggcttccag tggcctttcc tcactctgta gtgtttgtgg ggataggttc   1500

catgcaagaa caccttcctc ctccatcccc cacttcaccc catcccatac cagttccatc   1560

cagggtctgc ttaactgcca agagcaggtc ctggagttcc cttcacctgc agagtccttt   1620

tcatgaccta ggaggtctta ttcaaagccc tcattgacag aggaggaaac aggccaaggc   1680

aggacatggc tggaccatgg tgatacagct ctgtgtgatt caagttctgg cagagcttgt   1740

aaggctagag cccaggtctg ccgacaccct gtgcttgttg cacacttgat ttgctaaggc   1800

tggagacagg caccattgcc atggggctgg tcctagtcac tggccgagga taagcccgtc   1860

cctgtcccac attctagccc cactatgcgg gggtgctgtt gtcctgcctg tgtctcatcc   1920

ccggctgcct aagctaggga cactcaagtg cttccttcct tgccccatct tcctcccaac   1980

tggaggcctc tgagcctccc ctgtgccttg ggccctgaag ccccatatgt agtatagagc   2040

aaaggtggct cctggtgaag agagggtgga aaggcccttc agccccaggg ccatgtctgg   2100

gttctccatg cccatcagtc tctgcagttt ctctacctgc ccccagagct gaggccatct   2160

gcaagcccct gcccatggcc caatggggag cctccagcca caagttccct gtccttatca   2220

gccactgggt ggttcccact gcatgaccct ctatccctgc catctgtccc catggtttcc   2280

agctcaatcc acccctgacc catctgtcag ctttttccca gggagccgtt tcaggggttc   2340

tgggcagtag gctgggcctg gcctcagaac ctggtggctc ctgcctgctc cttcactttt   2400

gtaaaaccat ccccttcacc agaatggtat taactcctgg tgctttgtac tactggtcca   2460

gctgccctgg gctccttttc tatattaata aagaaacgag taaaaattaa aaaaaaaaaa   2520

aaaaaaaaaa aaaaaaaaaa aaa                                           2543


<210>  3163
<211>  342
<212>  PRT
<213>  Homosapiens

<400>  3163

Met Ala Asp Asp Leu Glu Gln Gln Ser Gln Gly Trp Leu Ser Ser Trp 
1               5                   10                  15      


Leu Pro Thr Trp Arg Pro Thr Ser Met Ser Gln Leu Lys Asn Val Glu 
            20                  25                  30          


Ala Arg Ile Leu Gln Cys Leu Gln Asn Lys Phe Leu Ala Arg Tyr Val 
        35                  40                  45              


Ser Leu Pro Asn Gln Asn Lys Ile Trp Thr Val Thr Val Ser Pro Glu 
    50                  55                  60                  


Gln Asn Asp Arg Thr Pro Leu Val Met Val His Gly Phe Gly Gly Gly 
65                  70                  75                  80  


Val Gly Leu Trp Ile Leu Asn Met Asp Ser Leu Ser Ala Arg Arg Thr 
                85                  90                  95      


Leu His Thr Phe Asp Leu Leu Gly Phe Gly Arg Ser Ser Arg Pro Ala 
            100                 105                 110         


Phe Pro Arg Asp Pro Glu Gly Ala Glu Asp Glu Phe Val Thr Ser Ile 
        115                 120                 125             


Glu Thr Trp Arg Glu Thr Met Gly Ile Pro Ser Met Ile Leu Leu Gly 
    130                 135                 140                 


His Ser Leu Gly Gly Phe Leu Ala Thr Ser Tyr Ser Ile Lys Tyr Pro 
145                 150                 155                 160 


Asp Arg Val Lys His Leu Ile Leu Val Asp Pro Trp Gly Phe Pro Leu 
                165                 170                 175     


Arg Pro Thr Asn Pro Ser Glu Ile Arg Ala Pro Pro Ala Trp Val Lys 
            180                 185                 190         


Ala Val Ala Ser Val Leu Gly Arg Ser Asn Pro Leu Ala Val Leu Arg 
        195                 200                 205             


Val Ala Gly Pro Trp Gly Pro Gly Leu Val Gln Arg Phe Arg Pro Asp 
    210                 215                 220                 


Phe Lys Arg Lys Phe Ala Asp Phe Phe Glu Asp Asp Thr Ile Ser Glu 
225                 230                 235                 240 


Tyr Ile Tyr His Cys Asn Ala Gln Asn Pro Ser Gly Glu Thr Ala Phe 
                245                 250                 255     


Lys Ala Met Met Glu Ser Phe Gly Trp Ala Arg Arg Pro Met Leu Glu 
            260                 265                 270         


Arg Ile His Leu Ile Arg Lys Asp Val Pro Ile Thr Met Ile Tyr Gly 
        275                 280                 285             


Ser Asp Thr Trp Ile Asp Thr Ser Thr Gly Lys Lys Val Lys Met Gln 
    290                 295                 300                 


Arg Pro Asp Ser Tyr Val Arg Asp Met Glu Ile Lys Gly Ala Ser His 
305                 310                 315                 320 


His Val Tyr Ala Asp Gln Pro His Ile Phe Asn Ala Val Val Glu Glu 
                325                 330                 335     


Ile Cys Asp Ser Val Asp 
            340         


<210>  3164
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3164
cggacgcccg gcgagtggcg gaaagcgaga ccccggcgcc gagtgaggtc ggccaggctg     60

ctgccgactt ccccgctggc ccctttgttc ccctcccggg gccctgccgg cggcggttcc    120

cggttgcccg cgccagagcc tcaggccggc tccttttgcc cttgagaagg gttcgctgcc    180

aggccttcga gttccgggcg cagctcccgg gagagccggc gccctgcctg gcccggcggc    240

ctcctctcgg gcacgaaggc ttgctgctgc ttctccagaa cttcccttcc tcgtagacac    300

agcaaagaga cttttaaaaa accatggcag atgtggaccc agatacattg ctggaatggc    360

tacagatggg acagggagat gaaagggaca tgcaactaat agcccttgaa cagctatgca    420

tgctgctttt gatgtctgac aacgtggatc gttgttttga aacatgtcct cctcgcactt    480

tcttaccagc cctttgcaaa atttttcttg atgaaagtgc tccagacaat gtattagagg    540

tgacagcccg tgccataaca tactacctgg atgtatctgc ggaatgtacc cgaaggattg    600

ttggggtaga tggagctata aaagcacttt gtaatcgttt ggttgtagtt gaacttaaca    660

acaggactag cagagactta gctgaacagt gtgtaaaggt attagaactg atatgtactc    720

gtgagtcagg agcagtcttt gaggctggtg gtttgaattg tgtgcttacc ttcattcgtg    780

acagtggaca tctagttcat aaagacacct tgcactctgc tatggctgtg gtatcaagac    840

tctgtggcaa aatggagcct caagattctt ctttagaaat ttgtgtagaa tctctgtcta    900

gtttattaaa gcatgaagat catcaggttt cagatggagc tctgcgatgc tttgcatcac    960

tggctgaccg atttacccgt cgtggtgttg acccagctcc attagccaag catggattaa   1020

ctgaggagct gttatctcga atggctgctg ctggtggtac tgtttcagga ccatcatcag   1080

catgcaaacc aggtcgcagc accacaggag ctccatccac cactgcagat tccaaattga   1140

gtaatcaggt gtcaacaatt gtaagtctgc tctcaacact ttgcagaggc tctccggtag   1200

taacacatga tcttctgagg tcggagcttc cagattcaat tgaaagtgca ttgcagggtg   1260

atgaaagatg tgtgcttgat actatgcgtt tggttgacct tctcttggtg ctattatttg   1320

aaggacgaaa agctttgcca aagtctagtg ctggatctac aggcagaatc ccaggactcc   1380

ggagattaga tagttctggg gagcgctcac atcggcagct tatagattgt attcgaagta   1440

aagataccga tgcacttata gatgcaattg acacaggagc ctttgaagta aattttatgg   1500

atgatgtagg tcagactcta ttaaactggg cctctgcttt tggaactcag gaaatggtag   1560

aatttctttg tgagagaggt gcagatgtta atagaggtca aaggtcatca tcattacatt   1620

atgctgcatg ttttggaaga cctcaagtag caaagactct gttacggcat ggtgcaaatc   1680

cagatctgag agatgaagat gggaaaactc cattagataa agctcgagaa aggggccata   1740

gtgaagtggt agctattctt cagtctccag gtgattggat gtgtccagtt aataaaggag   1800

atgataagaa aaaaaaagat acaaacaaag atgaagaaga atgtaatgag cccaaaggag   1860

atccggaaat ggcacccata tacttgaaaa ggttattgcc agtgtttgca caaacatttc   1920

agcaaactat gctgccttca ataaggaaag caagtcttgc tctaattcga aaaatgattc   1980

atttttgctc tgaagcactg ttacaagaag tttgtgattc tgatgttggt cacaatttgc   2040

ctacaatact agtggaaatc actgcaactg tccttgatca agaggatgat gatgatggcc   2100

acttgctagc tttgcagatc ataagggata tagtagataa aggtggtgat atatacaagc   2160

atcagctagc cagacttggt gtaataagca aagtgtcaac gttggcaggt ccttcctctg   2220

atgatgagaa tgaagaggaa tcaaaaccag aaaaagaaga tgaaccacag gaagatgctc   2280

aagaattgca acaaggtaaa ccatatcatt ggagagactg gtcaatcatt aggggaaggg   2340

actgcttata tatttggagt gatgcagcag ccttggaatt atctaatggc agtaatggat   2400

ggttcagatt tatcttggat ggaaaacttg ccaccatgta ttcaagtggt agtccggaag   2460

gtggatctga cagttcagaa agccgaagtg aattcttaga gaagttacaa agagctcgag   2520

gccaagtaaa gccatctact tcaagtcaac ctatactgtc agcaccagga cccactaaac   2580

ttactgtagg aaattggtca ctgacatgtt tgaaagaagg agaaattgct attcataatt   2640

cagatggtca gcaagctaca atattgaaag aagatttacc tggttttgta tttgaatcta   2700

atagaggaac caaacattca tttactgcag aaacttccct gggttcagaa tttgtgactg   2760

gctggactgg caaaagaggc agaaaactga aatctaagtt agaaaaaaca aagcaaaagg   2820

tacgaactat ggctcgagat ttatacgatg accattttaa agctgttgaa agcatgcctc   2880

gtggagtagt ggtgacactc agaaacatag caactcagtt agagtcatct tgggaacttc   2940

atacaaatag acaatgtatt gaaagtgaga acacttggag agatttaatg aagacagctt   3000

taaaaaacct aattgtactt ttgaaggatg aaaacacaat ttcaccatat gaaatgtgta   3060

gcagtggctt ggtacaagca cttcttactg tgttaaacaa tgtaagtata tttagggcta   3120

caaagcaaaa acagaatgaa gtcccaaagg tgattttaag tgttttcaag actgcattca   3180

ctgaaaatga agatgacgaa agtcgaccag cagttgcgtt aattcgaaag ttaatagctg   3240

tactagaatc tattgaacgt ctacctctcc atttgtatga tacaccagga tccacatata   3300

acctccagat acttacaagg agattacgat ttcggttgga acgtgcacct ggtgaaactg   3360

cattgattga caggactggc agaatgttga agatggaacc tttggctaca gttgaatctc   3420

tggaacagta ccttttgaaa atggtagcaa aacagtggta tgattttgac cgatcttcat   3480

ttgtttttgt tcgaaaatta agagaaggac aaaattttat atttcggcac cagcatgatt   3540

ttgatgaaaa tggaatcatt tactggattg gaacaaatgc aaaaactgct tatgaatggg   3600

taaatccagc tgcctatgga cttgtagtag taacgtcatc agaaggaaga aatctacctt   3660

atggccgctt agaagacata ctaagtcgtg ataattcagc tttaaattgt catagcaatg   3720

atgataagaa tgcctggttt gccatagatc tgggtctctg ggtgatacca tcagcatata   3780

cacttcgtca tgctcgtggt tatggaaggt ctgcactgag aaattgggtt ttccaggtat   3840

ccaaagatgg acagaactgg acttctttgt atacccatgt tgatgactgc agtctcaatg   3900

aaccagggtc aactgcaact tggcctcttg atccaccaaa ggatgagaaa caagggtgga   3960

gacatgtgag aattaaacag atggggaaaa atgccagtgg acaaacacac tacctctcat   4020

tatctggatt cgaactttat ggcactgtaa atggagtatg tgaagatcag ctagggaaag   4080

cagctaaaga agcagaagct aatcttagac ggcagagacg tctagtacgt tcccaggttc   4140

tgaaatacat ggttccagga gctcgtgtta tcagaggcct ggattggaaa tggcgagatc   4200

aggatggcag cccacaggga gaaggcactg tcacaggaga actacacaat ggctggattg   4260

atgtcacctg ggatgctggt ggctcaaact cttaccgtat gggcgcagaa ggaaaatttg   4320

acctcaagct tgcaccaggg tacgaccctg atacagtggc atcacccaaa cctgtttcat   4380

ccactgtttc aggcacaacg caatcatgga gcagcttggt gaaaaacaac tgtccagaca   4440

agacatctgc tgctgcaggc tcctcaagta gaaaaggaag cagcagttct gtgtgtagcg   4500

tggccagtag cagcgacatc agcttgggtt cgaccaaaac ggaacggaga tcagaaattg   4560

taatggaaca cagtatagtt tcaggagctg atgtccatga accaattgtt gttctttcat   4620

ctgctgaaaa cgtccctcaa acagaagtag ggtcatcttc cagtgcaagc accagcacct   4680

taacagcgga aacgggaagt gaaaatgctg aaaggaagtt aggccctgat agttctgttc   4740

gtactcctgg ggagtctagt gcaatatcca tgggaattgt cagtgttagt tctcctgatg   4800

ttagttcagt atctgaatta actaataaag aagcagcttc acaacgacct cttagctctt   4860

cagcaagtaa cagactgtca gtgagttctt tgttggctgc tggggcccct atgagctcta   4920

gtgcaagtgt acctaacctg tcctcaagag aaacatctag cttggagagt tttgtaagga   4980

gagtggcaaa catagcacgg actaatgcca cgaacaacat gaatctaagc cgaagcagca   5040

gtgataacaa cactaatact ttggggagga atgtgatgag cacagcaact tctcctctta   5100

tgggtgctca gagtttccct aatttgacca cacctggtac tacatcaaca gtgactatgt   5160

caacatccag tgttactagc agcagcaatg tagctacagc aacaacagtt ttatcagttg   5220

gtcaatcttt aagtaacact ttaaccacca gcctcacatc aacttccagt gagagtgaca   5280

caggtcagga agcagaatat tccttatatg atttccttga tagctgccgt gccagtactc   5340

tattggctga gctcgatgat gatgaggact tacctgagcc agatgaagaa gatgatgaga   5400

atgaagatga caatcaggag gaccaagaat acgaggaggt tatgattctg agacgcccat   5460

ccctgcaacg tcgagctggc tcccgctctg atgtaacgca tcatgctgtt acctcgcagc   5520

taccacaggt acctgctgga gcagggagcc gacctattgg ggagcaggaa gaagaagagt   5580

acgaaactaa aggaggacgc cggagaacat gggatgatga ttatgtgcta aagagacagt   5640

tttctgcatt ggttcctgct tttgatccta gacctggtcg tactaatgtc cagcagacaa   5700

ctgatctaga aataccaccc ccagggaccc ctcattcaga gctcttggaa gaagtcgaat   5760

gtactccgtc acctcgatta gctctcactt tgaaagtaac aggtcttgga acgactcgtg   5820

aagttgaatt accactcacc aatttcagat caaccatctt ttactatgta caaaaattgc   5880

ttcaattgtc ctgtaatggc aatgtgaaat cagataaact taggcgtatt tgggagccca   5940

catacacaat catgtacaga gaaatgaagg attctgataa agaaaaggaa aatggaaaaa   6000

tgggttgctg gtctatagag catgtggagc agtaccttgg cactgatgaa ttaccaaaga   6060

atgacttgat aacctacctg cagaagaatg cagacgctgc tttcctgcgc cactggaaat   6120

taactggcac taataaaagt attaggaaaa acagaaattg ttctcagctc atagctgcat   6180

ataaggattt ttgtgagcat ggaacaaagt ctgggttaaa ccagggggcc atttctactc   6240

ttcaaagtag tgatattctt aatttaacaa aagaacaacc tcaggccaaa gcaggcaatg   6300

gacagaactc ttgtggagta gaagatgtcc ttcagcttct gcgtattcta tatatagttg   6360

caagtgaccc ttattcaaga atatcccagg aagatggtga tgaacagctt cagtttactt   6420

ttccaccaga tgaattcact agcaaaaaaa ttacaacaaa aatattacag cagattgagg   6480

aaccattggc actggcaagt ggggctctgc cagactggtg tgaacaatta accagcaaat   6540

gtccttttct aataccattt gaaactagac agctttattt cacatgtaca gcatttggcg   6600

cctcaagagc aatagtatgg ttacagaacc gacgtgaagc cactgtggag cgaacgagaa   6660

ccacaagcag tgttaggcga gatgaccctg gagagtttcg agttggtcgt ctcaagcatg   6720

aaagagtaaa agttccacgt ggcgagtcac tgatggaatg ggctgagaat gtcatgcaaa   6780

tacatgcaga tcggaaatca gttcttgagg ttgaattttt aggagaagaa ggaactggct   6840

tgggacccac attagagttt tatgctctgg tggcagcaga attccagaga actgacttgg   6900

gagcttggct ttgtgatgat aattttccag atgatgaatc tcgtcacgtt gatcttggag   6960

gtggattgaa acctcctgga tattatgtgc agaggtcatg tggactgttc acagcaccat   7020

ttccacagga tagtgatgag cttgaaagga tcacgaaact gtttcatttc cttggaattt   7080

tcttggccaa atgcattcaa gacaatagac ttgtggactt acctatttct aaaccttttt   7140

ttaaacttat gtgtatgggt gacattaaaa gcaatatgag taaactgatt tatgagtcac   7200

gaggtgatag agacttacac tgtactgaaa gtcagtctga agcttctaca gaagaaggtc   7260

atgattcact ctcggtagga agctttgaag aggattcaaa atcagaattt attcttgatc   7320

cccctaaacc aaaaccccca gcttggttta atggaatttt gacttgggaa gactttgaat   7380

tagtaaaccc acacagagcc agatttttaa aagaaattaa agaccttgct atcaagaggc   7440

gccaaatttt aagcaacaaa ggtctttctg aagatgagaa gaacacaaaa ttacaggaac   7500

tagtgctgaa gaatccatca ggttctgggc ctccacttag catagaggat ttaggtttaa   7560

atttccagtt ttgcccttcc tcaagaatat atggttttac agctgtggat ctcaagccaa   7620

gtggtgaaga tgagatgata acaatggata atgcagaaga atatgtggat ttgatgtttg   7680

acttttgtat gcatacgggt attcagaaac aaatggaagc ctttagagat gggtttaata   7740

aagtttttcc aatggagaaa ttaagttcct tcagccatga agaagtccaa atgattcttt   7800

gtggaaacca gtcaccatcc tgggcagcag aggatattat caattacact gaacctaagc   7860

tgggttatac acgtgacagc cctggtttcc tgaggtttgt gagggtttta tgtggcatgt   7920

cttctgatga aaggaaagca ttcttgcagt ttaccactgg ttgttcaact ctacccccag   7980

gtggactggc taacctgcat cccaggctca cggttgtacg caaggttgat gctactgatg   8040

caagctatcc atcagtcaat acatgtgtgc attaccttaa gttgcctgaa tattcttccg   8100

aggagatcat gagagagcgc ctgctagctg ctacaatgga gaaaggcttt catctcaatt   8160

gagctttgaa gtgcaatggg agacatcaga ga                                 8192


<210>  3165
<211>  2612
<212>  PRT
<213>  Homosapiens

<400>  3165

Met Ala Asp Val Asp Pro Asp Thr Leu Leu Glu Trp Leu Gln Met Gly 
1               5                   10                  15      


Gln Gly Asp Glu Arg Asp Met Gln Leu Ile Ala Leu Glu Gln Leu Cys 
            20                  25                  30          


Met Leu Leu Leu Met Ser Asp Asn Val Asp Arg Cys Phe Glu Thr Cys 
        35                  40                  45              


Pro Pro Arg Thr Phe Leu Pro Ala Leu Cys Lys Ile Phe Leu Asp Glu 
    50                  55                  60                  


Ser Ala Pro Asp Asn Val Leu Glu Val Thr Ala Arg Ala Ile Thr Tyr 
65                  70                  75                  80  


Tyr Leu Asp Val Ser Ala Glu Cys Thr Arg Arg Ile Val Gly Val Asp 
                85                  90                  95      


Gly Ala Ile Lys Ala Leu Cys Asn Arg Leu Val Val Val Glu Leu Asn 
            100                 105                 110         


Asn Arg Thr Ser Arg Asp Leu Ala Glu Gln Cys Val Lys Val Leu Glu 
        115                 120                 125             


Leu Ile Cys Thr Arg Glu Ser Gly Ala Val Phe Glu Ala Gly Gly Leu 
    130                 135                 140                 


Asn Cys Val Leu Thr Phe Ile Arg Asp Ser Gly His Leu Val His Lys 
145                 150                 155                 160 


Asp Thr Leu His Ser Ala Met Ala Val Val Ser Arg Leu Cys Gly Lys 
                165                 170                 175     


Met Glu Pro Gln Asp Ser Ser Leu Glu Ile Cys Val Glu Ser Leu Ser 
            180                 185                 190         


Ser Leu Leu Lys His Glu Asp His Gln Val Ser Asp Gly Ala Leu Arg 
        195                 200                 205             


Cys Phe Ala Ser Leu Ala Asp Arg Phe Thr Arg Arg Gly Val Asp Pro 
    210                 215                 220                 


Ala Pro Leu Ala Lys His Gly Leu Thr Glu Glu Leu Leu Ser Arg Met 
225                 230                 235                 240 


Ala Ala Ala Gly Gly Thr Val Ser Gly Pro Ser Ser Ala Cys Lys Pro 
                245                 250                 255     


Gly Arg Ser Thr Thr Gly Ala Pro Ser Thr Thr Ala Asp Ser Lys Leu 
            260                 265                 270         


Ser Asn Gln Val Ser Thr Ile Val Ser Leu Leu Ser Thr Leu Cys Arg 
        275                 280                 285             


Gly Ser Pro Val Val Thr His Asp Leu Leu Arg Ser Glu Leu Pro Asp 
    290                 295                 300                 


Ser Ile Glu Ser Ala Leu Gln Gly Asp Glu Arg Cys Val Leu Asp Thr 
305                 310                 315                 320 


Met Arg Leu Val Asp Leu Leu Leu Val Leu Leu Phe Glu Gly Arg Lys 
                325                 330                 335     


Ala Leu Pro Lys Ser Ser Ala Gly Ser Thr Gly Arg Ile Pro Gly Leu 
            340                 345                 350         


Arg Arg Leu Asp Ser Ser Gly Glu Arg Ser His Arg Gln Leu Ile Asp 
        355                 360                 365             


Cys Ile Arg Ser Lys Asp Thr Asp Ala Leu Ile Asp Ala Ile Asp Thr 
    370                 375                 380                 


Gly Ala Phe Glu Val Asn Phe Met Asp Asp Val Gly Gln Thr Leu Leu 
385                 390                 395                 400 


Asn Trp Ala Ser Ala Phe Gly Thr Gln Glu Met Val Glu Phe Leu Cys 
                405                 410                 415     


Glu Arg Gly Ala Asp Val Asn Arg Gly Gln Arg Ser Ser Ser Leu His 
            420                 425                 430         


Tyr Ala Ala Cys Phe Gly Arg Pro Gln Val Ala Lys Thr Leu Leu Arg 
        435                 440                 445             


His Gly Ala Asn Pro Asp Leu Arg Asp Glu Asp Gly Lys Thr Pro Leu 
    450                 455                 460                 


Asp Lys Ala Arg Glu Arg Gly His Ser Glu Val Val Ala Ile Leu Gln 
465                 470                 475                 480 


Ser Pro Gly Asp Trp Met Cys Pro Val Asn Lys Gly Asp Asp Lys Lys 
                485                 490                 495     


Lys Lys Asp Thr Asn Lys Asp Glu Glu Glu Cys Asn Glu Pro Lys Gly 
            500                 505                 510         


Asp Pro Glu Met Ala Pro Ile Tyr Leu Lys Arg Leu Leu Pro Val Phe 
        515                 520                 525             


Ala Gln Thr Phe Gln Gln Thr Met Leu Pro Ser Ile Arg Lys Ala Ser 
    530                 535                 540                 


Leu Ala Leu Ile Arg Lys Met Ile His Phe Cys Ser Glu Ala Leu Leu 
545                 550                 555                 560 


Gln Glu Val Cys Asp Ser Asp Val Gly His Asn Leu Pro Thr Ile Leu 
                565                 570                 575     


Val Glu Ile Thr Ala Thr Val Leu Asp Gln Glu Asp Asp Asp Asp Gly 
            580                 585                 590         


His Leu Leu Ala Leu Gln Ile Ile Arg Asp Ile Val Asp Lys Gly Gly 
        595                 600                 605             


Asp Ile Tyr Lys His Gln Leu Ala Arg Leu Gly Val Ile Ser Lys Val 
    610                 615                 620                 


Ser Thr Leu Ala Gly Pro Ser Ser Asp Asp Glu Asn Glu Glu Glu Ser 
625                 630                 635                 640 


Lys Pro Glu Lys Glu Asp Glu Pro Gln Glu Asp Ala Gln Glu Leu Gln 
                645                 650                 655     


Gln Gly Lys Pro Tyr His Trp Arg Asp Trp Ser Ile Ile Arg Gly Arg 
            660                 665                 670         


Asp Cys Leu Tyr Ile Trp Ser Asp Ala Ala Ala Leu Glu Leu Ser Asn 
        675                 680                 685             


Gly Ser Asn Gly Trp Phe Arg Phe Ile Leu Asp Gly Lys Leu Ala Thr 
    690                 695                 700                 


Met Tyr Ser Ser Gly Ser Pro Glu Gly Gly Ser Asp Ser Ser Glu Ser 
705                 710                 715                 720 


Arg Ser Glu Phe Leu Glu Lys Leu Gln Arg Ala Arg Gly Gln Val Lys 
                725                 730                 735     


Pro Ser Thr Ser Ser Gln Pro Ile Leu Ser Ala Pro Gly Pro Thr Lys 
            740                 745                 750         


Leu Thr Val Gly Asn Trp Ser Leu Thr Cys Leu Lys Glu Gly Glu Ile 
        755                 760                 765             


Ala Ile His Asn Ser Asp Gly Gln Gln Ala Thr Ile Leu Lys Glu Asp 
    770                 775                 780                 


Leu Pro Gly Phe Val Phe Glu Ser Asn Arg Gly Thr Lys His Ser Phe 
785                 790                 795                 800 


Thr Ala Glu Thr Ser Leu Gly Ser Glu Phe Val Thr Gly Trp Thr Gly 
                805                 810                 815     


Lys Arg Gly Arg Lys Leu Lys Ser Lys Leu Glu Lys Thr Lys Gln Lys 
            820                 825                 830         


Val Arg Thr Met Ala Arg Asp Leu Tyr Asp Asp His Phe Lys Ala Val 
        835                 840                 845             


Glu Ser Met Pro Arg Gly Val Val Val Thr Leu Arg Asn Ile Ala Thr 
    850                 855                 860                 


Gln Leu Glu Ser Ser Trp Glu Leu His Thr Asn Arg Gln Cys Ile Glu 
865                 870                 875                 880 


Ser Glu Asn Thr Trp Arg Asp Leu Met Lys Thr Ala Leu Lys Asn Leu 
                885                 890                 895     


Ile Val Leu Leu Lys Asp Glu Asn Thr Ile Ser Pro Tyr Glu Met Cys 
            900                 905                 910         


Ser Ser Gly Leu Val Gln Ala Leu Leu Thr Val Leu Asn Asn Val Ser 
        915                 920                 925             


Ile Phe Arg Ala Thr Lys Gln Lys Gln Asn Glu Val Pro Lys Val Ile 
    930                 935                 940                 


Leu Ser Val Phe Lys Thr Ala Phe Thr Glu Asn Glu Asp Asp Glu Ser 
945                 950                 955                 960 


Arg Pro Ala Val Ala Leu Ile Arg Lys Leu Ile Ala Val Leu Glu Ser 
                965                 970                 975     


Ile Glu Arg Leu Pro Leu His Leu Tyr Asp Thr Pro Gly Ser Thr Tyr 
            980                 985                 990         


Asn Leu Gln Ile Leu Thr Arg Arg  Leu Arg Phe Arg Leu  Glu Arg Ala 
        995                 1000                 1005             


Pro Gly  Glu Thr Ala Leu Ile  Asp Arg Thr Gly Arg  Met Leu Lys 
    1010                 1015                 1020             


Met Glu  Pro Leu Ala Thr Val  Glu Ser Leu Glu Gln  Tyr Leu Leu 
    1025                 1030                 1035             


Lys Met  Val Ala Lys Gln Trp  Tyr Asp Phe Asp Arg  Ser Ser Phe 
    1040                 1045                 1050             


Val Phe  Val Arg Lys Leu Arg  Glu Gly Gln Asn Phe  Ile Phe Arg 
    1055                 1060                 1065             


His Gln  His Asp Phe Asp Glu  Asn Gly Ile Ile Tyr  Trp Ile Gly 
    1070                 1075                 1080             


Thr Asn  Ala Lys Thr Ala Tyr  Glu Trp Val Asn Pro  Ala Ala Tyr 
    1085                 1090                 1095             


Gly Leu  Val Val Val Thr Ser  Ser Glu Gly Arg Asn  Leu Pro Tyr 
    1100                 1105                 1110             


Gly Arg  Leu Glu Asp Ile Leu  Ser Arg Asp Asn Ser  Ala Leu Asn 
    1115                 1120                 1125             


Cys His  Ser Asn Asp Asp Lys  Asn Ala Trp Phe Ala  Ile Asp Leu 
    1130                 1135                 1140             


Gly Leu  Trp Val Ile Pro Ser  Ala Tyr Thr Leu Arg  His Ala Arg 
    1145                 1150                 1155             


Gly Tyr  Gly Arg Ser Ala Leu  Arg Asn Trp Val Phe  Gln Val Ser 
    1160                 1165                 1170             


Lys Asp  Gly Gln Asn Trp Thr  Ser Leu Tyr Thr His  Val Asp Asp 
    1175                 1180                 1185             


Cys Ser  Leu Asn Glu Pro Gly  Ser Thr Ala Thr Trp  Pro Leu Asp 
    1190                 1195                 1200             


Pro Pro  Lys Asp Glu Lys Gln  Gly Trp Arg His Val  Arg Ile Lys 
    1205                 1210                 1215             


Gln Met  Gly Lys Asn Ala Ser  Gly Gln Thr His Tyr  Leu Ser Leu 
    1220                 1225                 1230             


Ser Gly  Phe Glu Leu Tyr Gly  Thr Val Asn Gly Val  Cys Glu Asp 
    1235                 1240                 1245             


Gln Leu  Gly Lys Ala Ala Lys  Glu Ala Glu Ala Asn  Leu Arg Arg 
    1250                 1255                 1260             


Gln Arg  Arg Leu Val Arg Ser  Gln Val Leu Lys Tyr  Met Val Pro 
    1265                 1270                 1275             


Gly Ala  Arg Val Ile Arg Gly  Leu Asp Trp Lys Trp  Arg Asp Gln 
    1280                 1285                 1290             


Asp Gly  Ser Pro Gln Gly Glu  Gly Thr Val Thr Gly  Glu Leu His 
    1295                 1300                 1305             


Asn Gly  Trp Ile Asp Val Thr  Trp Asp Ala Gly Gly  Ser Asn Ser 
    1310                 1315                 1320             


Tyr Arg  Met Gly Ala Glu Gly  Lys Phe Asp Leu Lys  Leu Ala Pro 
    1325                 1330                 1335             


Gly Tyr  Asp Pro Asp Thr Val  Ala Ser Pro Lys Pro  Val Ser Ser 
    1340                 1345                 1350             


Thr Val  Ser Gly Thr Thr Gln  Ser Trp Ser Ser Leu  Val Lys Asn 
    1355                 1360                 1365             


Asn Cys  Pro Asp Lys Thr Ser  Ala Ala Ala Gly Ser  Ser Ser Arg 
    1370                 1375                 1380             


Lys Gly  Ser Ser Ser Ser Val  Cys Ser Val Ala Ser  Ser Ser Asp 
    1385                 1390                 1395             


Ile Ser  Leu Gly Ser Thr Lys  Thr Glu Arg Arg Ser  Glu Ile Val 
    1400                 1405                 1410             


Met Glu  His Ser Ile Val Ser  Gly Ala Asp Val His  Glu Pro Ile 
    1415                 1420                 1425             


Val Val  Leu Ser Ser Ala Glu  Asn Val Pro Gln Thr  Glu Val Gly 
    1430                 1435                 1440             


Ser Ser  Ser Ser Ala Ser Thr  Ser Thr Leu Thr Ala  Glu Thr Gly 
    1445                 1450                 1455             


Ser Glu  Asn Ala Glu Arg Lys  Leu Gly Pro Asp Ser  Ser Val Arg 
    1460                 1465                 1470             


Thr Pro  Gly Glu Ser Ser Ala  Ile Ser Met Gly Ile  Val Ser Val 
    1475                 1480                 1485             


Ser Ser  Pro Asp Val Ser Ser  Val Ser Glu Leu Thr  Asn Lys Glu 
    1490                 1495                 1500             


Ala Ala  Ser Gln Arg Pro Leu  Ser Ser Ser Ala Ser  Asn Arg Leu 
    1505                 1510                 1515             


Ser Val  Ser Ser Leu Leu Ala  Ala Gly Ala Pro Met  Ser Ser Ser 
    1520                 1525                 1530             


Ala Ser  Val Pro Asn Leu Ser  Ser Arg Glu Thr Ser  Ser Leu Glu 
    1535                 1540                 1545             


Ser Phe  Val Arg Arg Val Ala  Asn Ile Ala Arg Thr  Asn Ala Thr 
    1550                 1555                 1560             


Asn Asn  Met Asn Leu Ser Arg  Ser Ser Ser Asp Asn  Asn Thr Asn 
    1565                 1570                 1575             


Thr Leu  Gly Arg Asn Val Met  Ser Thr Ala Thr Ser  Pro Leu Met 
    1580                 1585                 1590             


Gly Ala  Gln Ser Phe Pro Asn  Leu Thr Thr Pro Gly  Thr Thr Ser 
    1595                 1600                 1605             


Thr Val  Thr Met Ser Thr Ser  Ser Val Thr Ser Ser  Ser Asn Val 
    1610                 1615                 1620             


Ala Thr  Ala Thr Thr Val Leu  Ser Val Gly Gln Ser  Leu Ser Asn 
    1625                 1630                 1635             


Thr Leu  Thr Thr Ser Leu Thr  Ser Thr Ser Ser Glu  Ser Asp Thr 
    1640                 1645                 1650             


Gly Gln  Glu Ala Glu Tyr Ser  Leu Tyr Asp Phe Leu  Asp Ser Cys 
    1655                 1660                 1665             


Arg Ala  Ser Thr Leu Leu Ala  Glu Leu Asp Asp Asp  Glu Asp Leu 
    1670                 1675                 1680             


Pro Glu  Pro Asp Glu Glu Asp  Asp Glu Asn Glu Asp  Asp Asn Gln 
    1685                 1690                 1695             


Glu Asp  Gln Glu Tyr Glu Glu  Val Met Ile Leu Arg  Arg Pro Ser 
    1700                 1705                 1710             


Leu Gln  Arg Arg Ala Gly Ser  Arg Ser Asp Val Thr  His His Ala 
    1715                 1720                 1725             


Val Thr  Ser Gln Leu Pro Gln  Val Pro Ala Gly Ala  Gly Ser Arg 
    1730                 1735                 1740             


Pro Ile  Gly Glu Gln Glu Glu  Glu Glu Tyr Glu Thr  Lys Gly Gly 
    1745                 1750                 1755             


Arg Arg  Arg Thr Trp Asp Asp  Asp Tyr Val Leu Lys  Arg Gln Phe 
    1760                 1765                 1770             


Ser Ala  Leu Val Pro Ala Phe  Asp Pro Arg Pro Gly  Arg Thr Asn 
    1775                 1780                 1785             


Val Gln  Gln Thr Thr Asp Leu  Glu Ile Pro Pro Pro  Gly Thr Pro 
    1790                 1795                 1800             


His Ser  Glu Leu Leu Glu Glu  Val Glu Cys Thr Pro  Ser Pro Arg 
    1805                 1810                 1815             


Leu Ala  Leu Thr Leu Lys Val  Thr Gly Leu Gly Thr  Thr Arg Glu 
    1820                 1825                 1830             


Val Glu  Leu Pro Leu Thr Asn  Phe Arg Ser Thr Ile  Phe Tyr Tyr 
    1835                 1840                 1845             


Val Gln  Lys Leu Leu Gln Leu  Ser Cys Asn Gly Asn  Val Lys Ser 
    1850                 1855                 1860             


Asp Lys  Leu Arg Arg Ile Trp  Glu Pro Thr Tyr Thr  Ile Met Tyr 
    1865                 1870                 1875             


Arg Glu  Met Lys Asp Ser Asp  Lys Glu Lys Glu Asn  Gly Lys Met 
    1880                 1885                 1890             


Gly Cys  Trp Ser Ile Glu His  Val Glu Gln Tyr Leu  Gly Thr Asp 
    1895                 1900                 1905             


Glu Leu  Pro Lys Asn Asp Leu  Ile Thr Tyr Leu Gln  Lys Asn Ala 
    1910                 1915                 1920             


Asp Ala  Ala Phe Leu Arg His  Trp Lys Leu Thr Gly  Thr Asn Lys 
    1925                 1930                 1935             


Ser Ile  Arg Lys Asn Arg Asn  Cys Ser Gln Leu Ile  Ala Ala Tyr 
    1940                 1945                 1950             


Lys Asp  Phe Cys Glu His Gly  Thr Lys Ser Gly Leu  Asn Gln Gly 
    1955                 1960                 1965             


Ala Ile  Ser Thr Leu Gln Ser  Ser Asp Ile Leu Asn  Leu Thr Lys 
    1970                 1975                 1980             


Glu Gln  Pro Gln Ala Lys Ala  Gly Asn Gly Gln Asn  Ser Cys Gly 
    1985                 1990                 1995             


Val Glu  Asp Val Leu Gln Leu  Leu Arg Ile Leu Tyr  Ile Val Ala 
    2000                 2005                 2010             


Ser Asp  Pro Tyr Ser Arg Ile  Ser Gln Glu Asp Gly  Asp Glu Gln 
    2015                 2020                 2025             


Leu Gln  Phe Thr Phe Pro Pro  Asp Glu Phe Thr Ser  Lys Lys Ile 
    2030                 2035                 2040             


Thr Thr  Lys Ile Leu Gln Gln  Ile Glu Glu Pro Leu  Ala Leu Ala 
    2045                 2050                 2055             


Ser Gly  Ala Leu Pro Asp Trp  Cys Glu Gln Leu Thr  Ser Lys Cys 
    2060                 2065                 2070             


Pro Phe  Leu Ile Pro Phe Glu  Thr Arg Gln Leu Tyr  Phe Thr Cys 
    2075                 2080                 2085             


Thr Ala  Phe Gly Ala Ser Arg  Ala Ile Val Trp Leu  Gln Asn Arg 
    2090                 2095                 2100             


Arg Glu  Ala Thr Val Glu Arg  Thr Arg Thr Thr Ser  Ser Val Arg 
    2105                 2110                 2115             


Arg Asp  Asp Pro Gly Glu Phe  Arg Val Gly Arg Leu  Lys His Glu 
    2120                 2125                 2130             


Arg Val  Lys Val Pro Arg Gly  Glu Ser Leu Met Glu  Trp Ala Glu 
    2135                 2140                 2145             


Asn Val  Met Gln Ile His Ala  Asp Arg Lys Ser Val  Leu Glu Val 
    2150                 2155                 2160             


Glu Phe  Leu Gly Glu Glu Gly  Thr Gly Leu Gly Pro  Thr Leu Glu 
    2165                 2170                 2175             


Phe Tyr  Ala Leu Val Ala Ala  Glu Phe Gln Arg Thr  Asp Leu Gly 
    2180                 2185                 2190             


Ala Trp  Leu Cys Asp Asp Asn  Phe Pro Asp Asp Glu  Ser Arg His 
    2195                 2200                 2205             


Val Asp  Leu Gly Gly Gly Leu  Lys Pro Pro Gly Tyr  Tyr Val Gln 
    2210                 2215                 2220             


Arg Ser  Cys Gly Leu Phe Thr  Ala Pro Phe Pro Gln  Asp Ser Asp 
    2225                 2230                 2235             


Glu Leu  Glu Arg Ile Thr Lys  Leu Phe His Phe Leu  Gly Ile Phe 
    2240                 2245                 2250             


Leu Ala  Lys Cys Ile Gln Asp  Asn Arg Leu Val Asp  Leu Pro Ile 
    2255                 2260                 2265             


Ser Lys  Pro Phe Phe Lys Leu  Met Cys Met Gly Asp  Ile Lys Ser 
    2270                 2275                 2280             


Asn Met  Ser Lys Leu Ile Tyr  Glu Ser Arg Gly Asp  Arg Asp Leu 
    2285                 2290                 2295             


His Cys  Thr Glu Ser Gln Ser  Glu Ala Ser Thr Glu  Glu Gly His 
    2300                 2305                 2310             


Asp Ser  Leu Ser Val Gly Ser  Phe Glu Glu Asp Ser  Lys Ser Glu 
    2315                 2320                 2325             


Phe Ile  Leu Asp Pro Pro Lys  Pro Lys Pro Pro Ala  Trp Phe Asn 
    2330                 2335                 2340             


Gly Ile  Leu Thr Trp Glu Asp  Phe Glu Leu Val Asn  Pro His Arg 
    2345                 2350                 2355             


Ala Arg  Phe Leu Lys Glu Ile  Lys Asp Leu Ala Ile  Lys Arg Arg 
    2360                 2365                 2370             


Gln Ile  Leu Ser Asn Lys Gly  Leu Ser Glu Asp Glu  Lys Asn Thr 
    2375                 2380                 2385             


Lys Leu  Gln Glu Leu Val Leu  Lys Asn Pro Ser Gly  Ser Gly Pro 
    2390                 2395                 2400             


Pro Leu  Ser Ile Glu Asp Leu  Gly Leu Asn Phe Gln  Phe Cys Pro 
    2405                 2410                 2415             


Ser Ser  Arg Ile Tyr Gly Phe  Thr Ala Val Asp Leu  Lys Pro Ser 
    2420                 2425                 2430             


Gly Glu  Asp Glu Met Ile Thr  Met Asp Asn Ala Glu  Glu Tyr Val 
    2435                 2440                 2445             


Asp Leu  Met Phe Asp Phe Cys  Met His Thr Gly Ile  Gln Lys Gln 
    2450                 2455                 2460             


Met Glu  Ala Phe Arg Asp Gly  Phe Asn Lys Val Phe  Pro Met Glu 
    2465                 2470                 2475             


Lys Leu  Ser Ser Phe Ser His  Glu Glu Val Gln Met  Ile Leu Cys 
    2480                 2485                 2490             


Gly Asn  Gln Ser Pro Ser Trp  Ala Ala Glu Asp Ile  Ile Asn Tyr 
    2495                 2500                 2505             


Thr Glu  Pro Lys Leu Gly Tyr  Thr Arg Asp Ser Pro  Gly Phe Leu 
    2510                 2515                 2520             


Arg Phe  Val Arg Val Leu Cys  Gly Met Ser Ser Asp  Glu Arg Lys 
    2525                 2530                 2535             


Ala Phe  Leu Gln Phe Thr Thr  Gly Cys Ser Thr Leu  Pro Pro Gly 
    2540                 2545                 2550             


Gly Leu  Ala Asn Leu His Pro  Arg Leu Thr Val Val  Arg Lys Val 
    2555                 2560                 2565             


Asp Ala  Thr Asp Ala Ser Tyr  Pro Ser Val Asn Thr  Cys Val His 
    2570                 2575                 2580             


Tyr Leu  Lys Leu Pro Glu Tyr  Ser Ser Glu Glu Ile  Met Arg Glu 
    2585                 2590                 2595             


Arg Leu  Leu Ala Ala Thr Met  Glu Lys Gly Phe His  Leu Asn 
    2600                 2605                 2610         


<210>  3166
<211>  4552
<212>  DNA
<213>  Homosapiens

<400>  3166
cggctgcagg ctgggaggga gaagtgctac gcctttgcag gttggcgaag tggttccagg     60

ctacccggct agtctggcac ggccccgtct tctgcctcct cctccgtcgc gtggcggcgg    120

gaactgttgg ccgcgcggcc tcgggaacgg cccaggtccc cgcccgcagg tcccgggcag    180

ataacataga tcatcagtag aaaacttctt gaagttgttc aagaaaaatt tgaaagtagc    240

aaaatagaaa ataaagaatt aacagcagat acagaggaca gcatggaagt gttgtcttag    300

gaaacagaac acagcagtga aaaaacagac aaaatccgct cagatacaac tgcagctgat    360

aatgttttcc ggcttcaatg tctttagagt tgggatctct tttgtcataa tgtgcatttt    420

ttacatgcca acagtaaact ctttaccaga actgagtcct cagaaatatt ttagtacatt    480

gcaaccagga aaagcctctt tagcttattt ttgtcaagct gattccccaa gaacatctgt    540

atttcttgaa gaactgaatg aggctgttag acctctgcag gactatggaa tttcagttgc    600

caaggttaat tgtgtcaaag aagaaatatc aagatactgt ggaaaagaaa aggatttgat    660

gaaagcatat ttattcaagg gcaacatatt gctcagagaa ttccctactg acaccttgtt    720

tgatgtgaat gccattgtcg cccatgttct ctttgctctt ctttttagtg aagtgaaata    780

tattaccaac ctggaagacc ttcagaacat agaaaatgct ctgaaaggaa aagcaaatat    840

tatattctca tatgtaagag ccattggaat accagagcac agagcagtca tggaagccgg    900

ttttgtgtat gggactacat accaatttgt cttaaccaca gaaattgccc ttttggaaag    960

tattggctct gaggatgtgg aatatgcaca tctctacttt tttcattgta aactagtctt   1020

ggacttgacc cagcaatgta gaagaacact aatggaacag ccattgacta cactgaacat   1080

tcacctgttt attaagacaa tgaaagcacc tctgttgact gaagttgctg aagatcctca   1140

acaagtttca actgtccatc tccaactggg cttaccactg gtttttattg ttagccaaca   1200

ggctacttat gaagctgata gaagaactgc agaatgggtt gcttggcgtc ttctgggaaa   1260

agcaggagtt ctactcttgt taagggactc tttggaagtg aacattcctc aagatgctaa   1320

tgtggtcttc aaaagagcag aagagggagt tccagtggaa tttttggtat tacatgatgt   1380

tgatttaata atatctcatg tggaaaataa tatgcacatt gaggaaatac aagaagatga   1440

agacaatgac atggaaggtc cagatataga tgttcaggat gatgaagtgg cagaaactgt   1500

tttcagagat aggaagagaa aattaccttt ggaacttaca gtggaactaa cagaagaaac   1560

atttaatgca acagtgatgg cttctgacag catagtactc ttctatgctg gttggcaagc   1620

agtatccatg gcatttttgc aatcctatat tgatgtggca gttaaactga aaggcacatc   1680

tactatgctt cttactagaa taaactgtgc agattggtct gatgtatgta ctaagcaaaa   1740

tgttactgaa tttcctatca taaagatgta caagaaaggc gagaacccag tatcttatgc   1800

tggaatgtta ggaaccaaag atctcctaaa atttatccag ctcaacagga tttcatatcc   1860

agtgaatata acatcgatcc aagaagcaga agaatattta agtggggaat tatataaaga   1920

cctcatcttg tattctagtg tgtcagtatt gggactattt agtccaacca tgaaaacagc   1980

aaaagaagat tttagtgaag caggaaacta cctaaaagga tatgttatca ctggaattta   2040

ttctgaagaa gatgttttgc tactgtcaac caaatatgct gcaagtcttc cagccctgct   2100

gcttgccaga cacacagaag gcaaaataga gagcatccca ctagctagca cacatgcaca   2160

agacatagtt caaataataa cagatgcact actggaaatg tttccggaaa tcactgtgga   2220

aaatcttccc agttatttca gacttcagaa accattattg attttgttca gtgatggcac   2280

tgtaaatcct caatataaaa aagcaatatt gacactggta aagcagaaat acttggattc   2340

atttactcca tgctggttaa atctaaagaa tactccagtg gggagaggaa tcttgcgggc   2400

atattttgat cctctgcctc cccttcctct tcttgttttg gtgaatctgc attcaggtgg   2460

ccaagtattt gcatttcctt cagaccaggc tataattgaa gaaaaccttg tattgtggct   2520

gaagaaatta gaagcaggac tagaaaatca tatcacaatt ttacctgctc aagaatggaa   2580

acctcctctt ccagcttatg attttctaag tatgatagat gccgcaacat ctcaacgtgg   2640

cactaggaaa gttcccaagt gtatgaaaga aacagatgtg caggagaatg ataaggaaca   2700

acatgaagat aaatcggcag tcagaaaaga accgattgaa actctgagaa taaagcattg   2760

gaatagaagt aattggttta aagaagcaga aaaatcattt agacgtgata aagagttagg   2820

atgctcaaaa gtgaactaat tttatagggc tgtggtttcc aaaatttttt tggcatgata   2880

gacttaattt atttccttaa agaataatat taaatcattt caagtttgca gactagtgcc   2940

atccaataga attataatat aagtcacata ttttatttaa aattttctag taactacatt   3000

aaacaaagta aaagtgagca gggcaaaata attttgatat tacttttcac ccagtagtat   3060

acccaaaata gcgaaatata gaaattatta atgagatatt ttacatcctt ttttgtacca   3120

agtcttctaa atgcagtaca tattttatac ttactgcatt tcttacttcc gagtagccat   3180

atttcaagtg ttcattgcca catgtggcct gtgactactg tattggacag ttcagtacta   3240

gacaaaaact agcataatta acttagttct agccatgatt tctatttgga ttaaaattaa   3300

actctaatca cagttaactc cacagtgcat tcatgcagct gacagttata tttgttttat   3360

tggagtcatg atattaaaat cagcgtttgt caacctcagg ggatatttag caattgtcgg   3420

gagacatttt tgatgtcatg actagggcag ttattgacat ttagtgagta gaggccatgg   3480

atcctgctaa ataacctgca ttggacagcg ccccacaaca aagaattatc ctgcccgaaa   3540

tggtagtcgt gccaaggctg agtaaccttg tgttaaaagt aacctgtggc agactaggtt   3600

tccagaattt cctggttctg ctcacgtatc atgtttgaaa aaattttggc tattaaagat   3660

atgtattaga tggtcttatc ctgattatta cctggataca acttgatctt ttctaatatt   3720

ttcagaaagt gatgggataa ccctagaaga ggactcagaa tgatatttat attttaagtg   3780

agtcttaaaa cctcctctta tttctacaag ttatatggct aaatttcaga ttgaacaggg   3840

attcagcatt ctgccatctc ctcatggaaa gagaggctcc ctcatctgaa gcgtctctga   3900

aatctaccct tgcaagcttc agacaaatca gttgatctcc ctgagccaca cggcctcatt   3960

ctgtgaggga gggaaagatt agccaaagag ttaattttca ttccaaatca cttagctgtt   4020

agactgatct gtttgtagca gttgtttgtc tcatttttgc tctgtgcatt ttttgagaca   4080

tttgttgaga atattctatt tggtgctcta ctgtattttt ctttttaata tctacttgat   4140

atcttgttct ttaaattttc ttcacatatg gtttgcctga tacaactgat ttttataact   4200

gaaatttaag gaatctaaca gctaaaactc agtaagtgca tctatttcct tataacatag   4260

acccgttgct actctcagca ccctctcctc aatttttttt cctgtagcat gtgatgcctg   4320

attaaactca ttttcatttg cttttatttc taatatggga acaatgagag tgaactctaa   4380

atataggttg tagtaataaa acatcattag cctaattatt agaaaatgct aattaagtac   4440

cagcacatag aaacatgaaa ttgcttagtc attgtacctt tgtcagcaat tttgacagtc   4500

attaatgttt gtcataattt taaataaagt gtctgggttt cagaatacct tc           4552


<210>  3167
<211>  825
<212>  PRT
<213>  Homosapiens

<400>  3167

Met Phe Ser Gly Phe Asn Val Phe Arg Val Gly Ile Ser Phe Val Ile 
1               5                   10                  15      


Met Cys Ile Phe Tyr Met Pro Thr Val Asn Ser Leu Pro Glu Leu Ser 
            20                  25                  30          


Pro Gln Lys Tyr Phe Ser Thr Leu Gln Pro Gly Lys Ala Ser Leu Ala 
        35                  40                  45              


Tyr Phe Cys Gln Ala Asp Ser Pro Arg Thr Ser Val Phe Leu Glu Glu 
    50                  55                  60                  


Leu Asn Glu Ala Val Arg Pro Leu Gln Asp Tyr Gly Ile Ser Val Ala 
65                  70                  75                  80  


Lys Val Asn Cys Val Lys Glu Glu Ile Ser Arg Tyr Cys Gly Lys Glu 
                85                  90                  95      


Lys Asp Leu Met Lys Ala Tyr Leu Phe Lys Gly Asn Ile Leu Leu Arg 
            100                 105                 110         


Glu Phe Pro Thr Asp Thr Leu Phe Asp Val Asn Ala Ile Val Ala His 
        115                 120                 125             


Val Leu Phe Ala Leu Leu Phe Ser Glu Val Lys Tyr Ile Thr Asn Leu 
    130                 135                 140                 


Glu Asp Leu Gln Asn Ile Glu Asn Ala Leu Lys Gly Lys Ala Asn Ile 
145                 150                 155                 160 


Ile Phe Ser Tyr Val Arg Ala Ile Gly Ile Pro Glu His Arg Ala Val 
                165                 170                 175     


Met Glu Ala Gly Phe Val Tyr Gly Thr Thr Tyr Gln Phe Val Leu Thr 
            180                 185                 190         


Thr Glu Ile Ala Leu Leu Glu Ser Ile Gly Ser Glu Asp Val Glu Tyr 
        195                 200                 205             


Ala His Leu Tyr Phe Phe His Cys Lys Leu Val Leu Asp Leu Thr Gln 
    210                 215                 220                 


Gln Cys Arg Arg Thr Leu Met Glu Gln Pro Leu Thr Thr Leu Asn Ile 
225                 230                 235                 240 


His Leu Phe Ile Lys Thr Met Lys Ala Pro Leu Leu Thr Glu Val Ala 
                245                 250                 255     


Glu Asp Pro Gln Gln Val Ser Thr Val His Leu Gln Leu Gly Leu Pro 
            260                 265                 270         


Leu Val Phe Ile Val Ser Gln Gln Ala Thr Tyr Glu Ala Asp Arg Arg 
        275                 280                 285             


Thr Ala Glu Trp Val Ala Trp Arg Leu Leu Gly Lys Ala Gly Val Leu 
    290                 295                 300                 


Leu Leu Leu Arg Asp Ser Leu Glu Val Asn Ile Pro Gln Asp Ala Asn 
305                 310                 315                 320 


Val Val Phe Lys Arg Ala Glu Glu Gly Val Pro Val Glu Phe Leu Val 
                325                 330                 335     


Leu His Asp Val Asp Leu Ile Ile Ser His Val Glu Asn Asn Met His 
            340                 345                 350         


Ile Glu Glu Ile Gln Glu Asp Glu Asp Asn Asp Met Glu Gly Pro Asp 
        355                 360                 365             


Ile Asp Val Gln Asp Asp Glu Val Ala Glu Thr Val Phe Arg Asp Arg 
    370                 375                 380                 


Lys Arg Lys Leu Pro Leu Glu Leu Thr Val Glu Leu Thr Glu Glu Thr 
385                 390                 395                 400 


Phe Asn Ala Thr Val Met Ala Ser Asp Ser Ile Val Leu Phe Tyr Ala 
                405                 410                 415     


Gly Trp Gln Ala Val Ser Met Ala Phe Leu Gln Ser Tyr Ile Asp Val 
            420                 425                 430         


Ala Val Lys Leu Lys Gly Thr Ser Thr Met Leu Leu Thr Arg Ile Asn 
        435                 440                 445             


Cys Ala Asp Trp Ser Asp Val Cys Thr Lys Gln Asn Val Thr Glu Phe 
    450                 455                 460                 


Pro Ile Ile Lys Met Tyr Lys Lys Gly Glu Asn Pro Val Ser Tyr Ala 
465                 470                 475                 480 


Gly Met Leu Gly Thr Lys Asp Leu Leu Lys Phe Ile Gln Leu Asn Arg 
                485                 490                 495     


Ile Ser Tyr Pro Val Asn Ile Thr Ser Ile Gln Glu Ala Glu Glu Tyr 
            500                 505                 510         


Leu Ser Gly Glu Leu Tyr Lys Asp Leu Ile Leu Tyr Ser Ser Val Ser 
        515                 520                 525             


Val Leu Gly Leu Phe Ser Pro Thr Met Lys Thr Ala Lys Glu Asp Phe 
    530                 535                 540                 


Ser Glu Ala Gly Asn Tyr Leu Lys Gly Tyr Val Ile Thr Gly Ile Tyr 
545                 550                 555                 560 


Ser Glu Glu Asp Val Leu Leu Leu Ser Thr Lys Tyr Ala Ala Ser Leu 
                565                 570                 575     


Pro Ala Leu Leu Leu Ala Arg His Thr Glu Gly Lys Ile Glu Ser Ile 
            580                 585                 590         


Pro Leu Ala Ser Thr His Ala Gln Asp Ile Val Gln Ile Ile Thr Asp 
        595                 600                 605             


Ala Leu Leu Glu Met Phe Pro Glu Ile Thr Val Glu Asn Leu Pro Ser 
    610                 615                 620                 


Tyr Phe Arg Leu Gln Lys Pro Leu Leu Ile Leu Phe Ser Asp Gly Thr 
625                 630                 635                 640 


Val Asn Pro Gln Tyr Lys Lys Ala Ile Leu Thr Leu Val Lys Gln Lys 
                645                 650                 655     


Tyr Leu Asp Ser Phe Thr Pro Cys Trp Leu Asn Leu Lys Asn Thr Pro 
            660                 665                 670         


Val Gly Arg Gly Ile Leu Arg Ala Tyr Phe Asp Pro Leu Pro Pro Leu 
        675                 680                 685             


Pro Leu Leu Val Leu Val Asn Leu His Ser Gly Gly Gln Val Phe Ala 
    690                 695                 700                 


Phe Pro Ser Asp Gln Ala Ile Ile Glu Glu Asn Leu Val Leu Trp Leu 
705                 710                 715                 720 


Lys Lys Leu Glu Ala Gly Leu Glu Asn His Ile Thr Ile Leu Pro Ala 
                725                 730                 735     


Gln Glu Trp Lys Pro Pro Leu Pro Ala Tyr Asp Phe Leu Ser Met Ile 
            740                 745                 750         


Asp Ala Ala Thr Ser Gln Arg Gly Thr Arg Lys Val Pro Lys Cys Met 
        755                 760                 765             


Lys Glu Thr Asp Val Gln Glu Asn Asp Lys Glu Gln His Glu Asp Lys 
    770                 775                 780                 


Ser Ala Val Arg Lys Glu Pro Ile Glu Thr Leu Arg Ile Lys His Trp 
785                 790                 795                 800 


Asn Arg Ser Asn Trp Phe Lys Glu Ala Glu Lys Ser Phe Arg Arg Asp 
                805                 810                 815     


Lys Glu Leu Gly Cys Ser Lys Val Asn 
            820                 825 


<210>  3168
<211>  4779
<212>  DNA
<213>  Homosapiens

<400>  3168
atgcagcgaa aagagaaagc aaaatgccct caggaggctc caggcagagc ccacagcctg     60

aagggccagc gctgtcacct acctgcccgg gacctgcggg cggggacctg ggccgttccc    120

gaggccgcgc ggccaacagt tcccgccgcc acgcgacgga ggaggaggca gaagacgggg    180

ccgtgccaga ctagccgggt agcctggaac cacttcgcca acctgcaaag gcgtagcact    240

tctccctccc agcctgcagc cgccaccgac tcggcggagt cggcctcctg ggaaaaaaca    300

acctgcgaag ctcctccttc tcctcgtgct ccctacgcga ggcactctct aaccaatggg    360

aaacgtggtg ggcggagcga gagtgacaga cgattacaga gtcctcccgc cggcgcgaac    420

gggcggtgca gtagcagggc caatcagcag cgtgggtggg aagtacaggg gcgggagaaa    480

gtagggaaat tacgcgccca atcagatctc ggggccctcg agcgacgggt cctgcggccc    540

gtggccttcc gagcgcggcg ctcagggggc gtgcctgcct gggccaatcg gcgcgagccc    600

acagtgcgga gcgagcgcct caaatgctcg ggtttctcag ctgattgtct ccagccgaga    660

gttgtttttt gcagctacgg agccgagccg cagcaggagg agccgagacc cccggggggt    720

ggggggaaag aggaggcggg gtccggggga gccgcggctg ctttgcgctg gactccgggt    780

cccgtcacgg cgcttcctgg gtccagcccc ttccttcccg cgctcgctcg cccggccccc    840

agccccctca tgagggtgtc cgtgccgggt ccggcggccg ctgccgcccc cgcagccggc    900

cgcgagccct ccacgcccgg cgggggcagc ggaggcggag gcgccgtcgc tgcagcctca    960

ggcgccgcgg tgccgggctc cgtgcagttg gcgctgagcg tcctgcacgc cctgctctac   1020

gccgcgctgt tcgcctttgc ctacctgcag ctgtggcggc tgctcctgta ccgcgagcgg   1080

cggctgagtt accagagcct ctgcctcttc ctctgtctcc tgtgggcagc gctcaggacc   1140

accctcttct ccgccgcctt ctcgctcagc ggctccctgc ccttgctccg gccgcccgct   1200

cacctgcact tcttccccca ctggctgctc tactgcttcc cctcctgtct ccagttctcc   1260

acgctctgtc tcctcaacct ctacctggcg gaggttatat gtaaagtcag atgtgccact   1320

gaacttgaca gacacaaaat tctactgcat ttgggcttta taatggcaag cctgctcttt   1380

ttagtggtga acttgacttg cgcaatgcta gttcatggag atgtcccaga aaatcagttg   1440

aagtggactg tgtttgttcg agcattaatt aatgatagcc tgtttattct ttgtgccatc   1500

tctttagtgt gttacatatg caaaattaca aaaatgtcat cagctaatgt ctacctcgaa   1560

tcaaagatta caggatctca ttctttctta tggctgaata gtactccatt gtgtggtatg   1620

tctctgtgcc agactgtcgt cgtgggctct gtagtcattc ttctgtactc ttccagagct   1680

tgttataatt tggtggtggt caccatatct caggatacat tagaaagtcc atttaattat   1740

ggctgggata atctttcaga taaggctcat gtagaagaca taagtggaga agagtatata   1800

gtatttggaa tggtcctctt tctgtgggaa catgtgccag catggtcggt ggtactgttt   1860

ttccgggcac agagattaaa ccagaatttg gcacctgctg gcatgataaa tagtcacagt   1920

tatagttcca gagcttactt tttcgacaat ccaagacgat atgatagtga tgatgacctg   1980

ccaagactgg gaagttcaag agaaggaagt ttaccaaatt cgcaaagttt gggctggtat   2040

ggcaccatga ctgggtgtgg cagcagcagt tacacagtca ctccccacct gaatggacct   2100

atgacagata ctgctccttt gctctttact tgtagtaatt tagatttgaa caatcatcat   2160

agcttatatg tgacaccaca aaactgacag catcaccaag tcatgattct tgagttgttt   2220

ttcataaatg tgtatattca atgtgtttaa attccatcta cataaacatt ccattatctg   2280

ttgcaactga aaacaaaatc tggaagtgtg gctgtgtttg gtaaataaca cagctattat   2340

ttttgacctc ttcatagtaa aatgaagtaa aatggaaagt ttggagtagg agaaaagaga   2400

gattagatct taaggcactt gatggcctcc aaaaatcctg actttggaac atcaaatgca   2460

tatgtgcact tttatctttg ttctgagtca ctgcagtccc caaagtcata tgccaatgtt   2520

cacactgaaa tactgtattg tacaccaaac tggaaggcaa ttttcctatg aaaatcaaag   2580

ccggtatatt cattggtatg ctctatacag atatcttaat aaaaatttta tagtgtgaac   2640

agtgcacaga gttaaggcat aaaaatgtat cattctttat aaaaatctac tgaaaatgtg   2700

taatcattga agacagttct tttaagcatg attttaaaat agcaactgaa attcaatcat   2760

tttaaacaaa tgatggtagt aatccattag ttatggccag cagtgttctt tggagagcca   2820

caataatttc aagaggaaaa tataccagtg aaaattgtgt ggctattttg agtagaattg   2880

gtcagttgat tattttgtgt aattgagata tatgtagtag tttaagcatg attcttgaag   2940

aaagcaatag tgacttttgc atagggagat tttggtagaa acttcttggg actaaacaag   3000

tttagagatg catttaagaa ttattcacaa aatgtgtaat tctaaattaa aacataaata   3060

tattttcaaa agcatttgat ttctctgaag catgatatag ctggtcttac ctagtgaatc   3120

aggattgtcc tcaggtaaat gaaatcatga tacattattg cagtgaactc aagtgcaata   3180

ctttgtaaga catataattc ctatgatttt cacattttta tatcttatat atgggaaaag   3240

ccaaattaaa ttgaattcag attaattcca gcattagact aaatgagcaa acttaagtaa   3300

atgtacaaac taggtaagta taaaaccaca ggttaacaat attggagtac ttttagaatt   3360

acattaaaac tgtcttaaat gtcctatccc aaatctaaaa aaaaagaaaa tggcaggctg   3420

agataataca gaattttaaa atgcactttg taccagtgtc tatatggaaa gaagtagatg   3480

ctgaatacct caagatgcca agggaacaag caacattggg aagttgtcac aacatgctca   3540

aagacaaact acaattgtct gctagctatt tcttcagaac tggaactaat acgactatcc   3600

ttttctgttt tatactttga ttagaatgtt atttcctcgc ttacttaaaa tgtacttcaa   3660

ctttttaaca actgatacaa taacttcata aaagtataac actaggttga aaccttaagg   3720

aaaaattgaa attgttaatg ctttcgatct tttgggaggc cagtacacag acaaataaat   3780

ttcttctttt tatgatacaa aatgactttg tattcaatca gaagcatata cttatgttat   3840

tttgggtttg tttataattc tctcattgta accaaattat tttaaaatgt atagtataaa   3900

aagttacccg tggtattaag tgacaaaagc gtacttttat tacaactcca gttgttagat   3960

tgcttctcag aatgctaact gtttattttg ctaataatgt taggcatcta atcatctaga   4020

gctgtccaaa aagatatgtt gtctttgtta atccttgggg ttcaaggtga taaagttttt   4080

ctagtaaggc tcccctcgat aatgttccta tttgaccaaa ctaacaaaga ttacttttta   4140

aaaatttttc agataaaata acttggttct ttctgctgca ttagttgatt gttccaaatt   4200

tgaggtttgt aagtttattc ttatcactga ctagggtacc caaattcttg catttgtctc   4260

cttatacaca tctaacatat caccaaagac aaataaagat acactctggc ccaatctttg   4320

cttaaaaatt ccaaagcact aggagcactt taagtttggt ctcgaaagga gttgtttata   4380

aaatcaaagg gctaccgatt ccctgttcat cctgcactga agcacatgat gacagtatca   4440

aaccttcatt tttgttcatt aaaaagtgaa tttcattact taagtgtgta attctatagt   4500

gattagcagt atttgttttc atcatttcac ttgggtggcc attaattttg aaacctttac   4560

cactcattgt agttggttgt agttttatgg aaaatgtaat ttatagctaa agtggctttt   4620

ttatgcatag ctgccttttt tattgtttaa cagtgtttct cagctatata atcagtttca   4680

aactggttgt aaaagtatag ctgtggccaa tgaatgtatt tatttgttgt ttcactaaat   4740

tgtaacaaaa cactactatt aaaaataaaa gtgtttgtg                          4779


<210>  3169
<211>  728
<212>  PRT
<213>  Homosapiens

<400>  3169

Met Gln Arg Lys Glu Lys Ala Lys Cys Pro Gln Glu Ala Pro Gly Arg 
1               5                   10                  15      


Ala His Ser Leu Lys Gly Gln Arg Cys His Leu Pro Ala Arg Asp Leu 
            20                  25                  30          


Arg Ala Gly Thr Trp Ala Val Pro Glu Ala Ala Arg Pro Thr Val Pro 
        35                  40                  45              


Ala Ala Thr Arg Arg Arg Arg Arg Gln Lys Thr Gly Pro Cys Gln Thr 
    50                  55                  60                  


Ser Arg Val Ala Trp Asn His Phe Ala Asn Leu Gln Arg Arg Ser Thr 
65                  70                  75                  80  


Ser Pro Ser Gln Pro Ala Ala Ala Thr Asp Ser Ala Glu Ser Ala Ser 
                85                  90                  95      


Trp Glu Lys Thr Thr Cys Glu Ala Pro Pro Ser Pro Arg Ala Pro Tyr 
            100                 105                 110         


Ala Arg His Ser Leu Thr Asn Gly Lys Arg Gly Gly Arg Ser Glu Ser 
        115                 120                 125             


Asp Arg Arg Leu Gln Ser Pro Pro Ala Gly Ala Asn Gly Arg Cys Ser 
    130                 135                 140                 


Ser Arg Ala Asn Gln Gln Arg Gly Trp Glu Val Gln Gly Arg Glu Lys 
145                 150                 155                 160 


Val Gly Lys Leu Arg Ala Gln Ser Asp Leu Gly Ala Leu Glu Arg Arg 
                165                 170                 175     


Val Leu Arg Pro Val Ala Phe Arg Ala Arg Arg Ser Gly Gly Val Pro 
            180                 185                 190         


Ala Trp Ala Asn Arg Arg Glu Pro Thr Val Arg Ser Glu Arg Leu Lys 
        195                 200                 205             


Cys Ser Gly Phe Ser Ala Asp Cys Leu Gln Pro Arg Val Val Phe Cys 
    210                 215                 220                 


Ser Tyr Gly Ala Glu Pro Gln Gln Glu Glu Pro Arg Pro Pro Gly Gly 
225                 230                 235                 240 


Gly Gly Lys Glu Glu Ala Gly Ser Gly Gly Ala Ala Ala Ala Leu Arg 
                245                 250                 255     


Trp Thr Pro Gly Pro Val Thr Ala Leu Pro Gly Ser Ser Pro Phe Leu 
            260                 265                 270         


Pro Ala Leu Ala Arg Pro Ala Pro Ser Pro Leu Met Arg Val Ser Val 
        275                 280                 285             


Pro Gly Pro Ala Ala Ala Ala Ala Pro Ala Ala Gly Arg Glu Pro Ser 
    290                 295                 300                 


Thr Pro Gly Gly Gly Ser Gly Gly Gly Gly Ala Val Ala Ala Ala Ser 
305                 310                 315                 320 


Gly Ala Ala Val Pro Gly Ser Val Gln Leu Ala Leu Ser Val Leu His 
                325                 330                 335     


Ala Leu Leu Tyr Ala Ala Leu Phe Ala Phe Ala Tyr Leu Gln Leu Trp 
            340                 345                 350         


Arg Leu Leu Leu Tyr Arg Glu Arg Arg Leu Ser Tyr Gln Ser Leu Cys 
        355                 360                 365             


Leu Phe Leu Cys Leu Leu Trp Ala Ala Leu Arg Thr Thr Leu Phe Ser 
    370                 375                 380                 


Ala Ala Phe Ser Leu Ser Gly Ser Leu Pro Leu Leu Arg Pro Pro Ala 
385                 390                 395                 400 


His Leu His Phe Phe Pro His Trp Leu Leu Tyr Cys Phe Pro Ser Cys 
                405                 410                 415     


Leu Gln Phe Ser Thr Leu Cys Leu Leu Asn Leu Tyr Leu Ala Glu Val 
            420                 425                 430         


Ile Cys Lys Val Arg Cys Ala Thr Glu Leu Asp Arg His Lys Ile Leu 
        435                 440                 445             


Leu His Leu Gly Phe Ile Met Ala Ser Leu Leu Phe Leu Val Val Asn 
    450                 455                 460                 


Leu Thr Cys Ala Met Leu Val His Gly Asp Val Pro Glu Asn Gln Leu 
465                 470                 475                 480 


Lys Trp Thr Val Phe Val Arg Ala Leu Ile Asn Asp Ser Leu Phe Ile 
                485                 490                 495     


Leu Cys Ala Ile Ser Leu Val Cys Tyr Ile Cys Lys Ile Thr Lys Met 
            500                 505                 510         


Ser Ser Ala Asn Val Tyr Leu Glu Ser Lys Ile Thr Gly Ser His Ser 
        515                 520                 525             


Phe Leu Trp Leu Asn Ser Thr Pro Leu Cys Gly Met Ser Leu Cys Gln 
    530                 535                 540                 


Thr Val Val Val Gly Ser Val Val Ile Leu Leu Tyr Ser Ser Arg Ala 
545                 550                 555                 560 


Cys Tyr Asn Leu Val Val Val Thr Ile Ser Gln Asp Thr Leu Glu Ser 
                565                 570                 575     


Pro Phe Asn Tyr Gly Trp Asp Asn Leu Ser Asp Lys Ala His Val Glu 
            580                 585                 590         


Asp Ile Ser Gly Glu Glu Tyr Ile Val Phe Gly Met Val Leu Phe Leu 
        595                 600                 605             


Trp Glu His Val Pro Ala Trp Ser Val Val Leu Phe Phe Arg Ala Gln 
    610                 615                 620                 


Arg Leu Asn Gln Asn Leu Ala Pro Ala Gly Met Ile Asn Ser His Ser 
625                 630                 635                 640 


Tyr Ser Ser Arg Ala Tyr Phe Phe Asp Asn Pro Arg Arg Tyr Asp Ser 
                645                 650                 655     


Asp Asp Asp Leu Pro Arg Leu Gly Ser Ser Arg Glu Gly Ser Leu Pro 
            660                 665                 670         


Asn Ser Gln Ser Leu Gly Trp Tyr Gly Thr Met Thr Gly Cys Gly Ser 
        675                 680                 685             


Ser Ser Tyr Thr Val Thr Pro His Leu Asn Gly Pro Met Thr Asp Thr 
    690                 695                 700                 


Ala Pro Leu Leu Phe Thr Cys Ser Asn Leu Asp Leu Asn Asn His His 
705                 710                 715                 720 


Ser Leu Tyr Val Thr Pro Gln Asn 
                725             


<210>  3170
<211>  3334
<212>  DNA
<213>  Homosapiens

<400>  3170
gcacgagccc cgggctgccg gcgcgggcgc cgcggcacgt ccacaggctg ggtcgcgagg     60

tggcgatcgc tgagaggcag gagggccgag gcgggcctgg gaggcggccc ggaggtgggg    120

cgccgctggg gccggcccgc acgggcttca tctgagggcg cacggcccgc gaccgagcgt    180

gcggactggc ctcccaagcg tggggcgaca agctgccgga gctgcaatgg gccgcggctg    240

gggattcttg tttggcctcc tgggcgccgt gtggctgctc agctcgggcc acggagagga    300

gcagcccccg gagacagcgg cacagaggtg cttctgccag gttagtggtt acttggatga    360

ttgtacctgt gatgttgaaa ccattgatag atttaataac tacaggcttt tcccaagact    420

acaaaaactt cttgaaagtg actactttag gtattacaag gtaaacctga agaggccgtg    480

tcctttctgg aatgacatca gccagtgtgg aagaagggac tgtgctgtca aaccatgtca    540

atctgatgaa gttcctgatg gaattaaatc tgcgagctac aagtattctg aagaagccaa    600

taatctcatt gaagaatgtg aacaagctga acgacttgga gcagtggatg aatctctgag    660

tgaggaaaca cagaaggctg ttcttcagtg gaccaagcat gatgattctt cagataactt    720

ctgtgaagct gatgacattc agtcccctga agctgaatat gtagatttgc ttcttaatcc    780

tgagcgctac actggttaca agggaccaga tgcttggaaa atatggaatg tcatctacga    840

agaaaactgt tttaagccac agacaattaa aagaccttta aatcctttgg cttctggtca    900

agggacaagt gaagagaaca ctttttacag ttggctagaa ggtctctgtg tagaaaaaag    960

agcattctac agacttatat ctggcctaca tgcaagcatt aatgtgcatt tgagtgcaag   1020

atatctttta caagagacct ggttagaaaa gaaatgggga cacaacatta cagaatttca   1080

acagcgattt gatggaattt tgactgaagg agaaggtcca agaaggctta agaacttgta   1140

ttttctctac ttaatagaac taagggcttt atccaaagtg ttaccattct tcgagcgccc   1200

agattttcaa ctctttactg gaaataaaat tcaggatgag gaaaacaaaa tgttacttct   1260

ggaaatactt catgaaatca agtcatttcc tttgcatttt gatgagaatt cattttttgc   1320

tggggataaa aaagaagcac acaaactaaa ggaggacttt cgactgcatt ttagaaatat   1380

ttcaagaatt atggattgtg ttggttgttt taaatgtcgt ctgtggggaa agcttcagac   1440

tcagggtttg ggcactgctc tgaagatctt attttctgag aaattgatag caaatatgcc   1500

agaaagtgga cctagttatg aattccatct aaccagacaa gaaatagtat cattattcaa   1560

cgcatttgga agaatttcta caagtgtgaa agaattagaa aacttcagga acttgttaca   1620

gaatattcat taaagaaaac aagctgatat gtgcctgttt ctggacaatg gaggcgaaag   1680

agtggaattt cattcaaagg cataatagca atgacagtct taagccaaac attttatata   1740

aagttgcttt tgtaaaggag aattatattg ttttaagtaa acacattttt aaaaattgtg   1800

ttaagtctat gtataatact actgtgagta aaagtaatac tttaataatg tggtacaaat   1860

tttaaagttt aatattgaat aaaaggagga ttatcaaatt catatatgat aaaagtgaat   1920

gttctaagtc tctcaaacta gcgttttatg taataatatg taatataaat aaaactatgg   1980

taaatgtgac aagcatttaa taggaaaatg ctaaggaggc ctcataaatg acccataatt   2040

accaacgtag aatttttcag tacatttagg gttgctggat ttagcaaata aaaataaaga   2100

ttgcccagtt agatttgaat ttcagataaa caattagttt tttaatattt tacatggaat   2160

atttggaaaa tacttatact aaaaaattat ttgtttgaaa ttcacattta actgggagtc   2220

ttgtatttta tctggcaatc ctaaaataca ttggtatgaa acaaatcact tttagaagta   2280

tattgctatt ttgattgggt tgtttttgtg tgtagaaacg tacaataaca actcaaaggc   2340

acaggagatt tctaaacatt gtgaaaagtt gaatagatta tatatttatt ctcataatac   2400

tttcactaat actaaataaa atttggggaa cactttttat ttttatataa tttccaattt   2460

acagaaaagt ttcaaaaata gtacaaagag ctctcttacc cagattcact aattgttcat   2520

acgtgcttta tctttcatgc tttctctgta cacacacaca cacacacaaa tttttcctca   2580

atcatttgaa agtcagttat aggcatcatg ccccttaaac cctaaatact tcagtgtgta   2640

atactgaata attactaaaa atgattttct cagaaaaaaa aactcccaca attctggaac   2700

tataatactg taagccttag aataaataat actttcaagt tccaatctaa agttcttttt   2760

gagttttgtt gcccgtttta tgcttgatgt gtatagtaat agggtaggct atttatttta   2820

ttaaaatttt ttttagagac aaggttttgc tgtgttgccc aagctggaac ttgaacgact   2880

gggctgaagt gatcttccca cctcagcctc ccaagtagct gggaatacag gtgtctgcca   2940

ccatacccag tttcattttt gttttttata cccgaagttc atttcctttg tctccctaaa   3000

actgaactgt aattttggga ggttttcatt agtggaagct cttcatttat aaagctattt   3060

gaaggggttt aggaatttat atcacatggt aattgtagag aaaaagaagc tatatacctc   3120

aaaatcgtgc cctctttaca tatgtcttat caggtataac atgttgaaat gtcacattag   3180

tagtaaagtg gggtttattt atatagtggt taagaaatgt cagtttacac tgctgtatac   3240

ttcttcttct gtgtccctaa ggcctggtac agtgccaagc acatacttgg tatccaataa   3300

atatttgttg gatgaaaaaa aaaaaaaaaa aaaa                               3334


<210>  3171
<211>  468
<212>  PRT
<213>  Homosapiens

<400>  3171

Met Gly Arg Gly Trp Gly Phe Leu Phe Gly Leu Leu Gly Ala Val Trp 
1               5                   10                  15      


Leu Leu Ser Ser Gly His Gly Glu Glu Gln Pro Pro Glu Thr Ala Ala 
            20                  25                  30          


Gln Arg Cys Phe Cys Gln Val Ser Gly Tyr Leu Asp Asp Cys Thr Cys 
        35                  40                  45              


Asp Val Glu Thr Ile Asp Arg Phe Asn Asn Tyr Arg Leu Phe Pro Arg 
    50                  55                  60                  


Leu Gln Lys Leu Leu Glu Ser Asp Tyr Phe Arg Tyr Tyr Lys Val Asn 
65                  70                  75                  80  


Leu Lys Arg Pro Cys Pro Phe Trp Asn Asp Ile Ser Gln Cys Gly Arg 
                85                  90                  95      


Arg Asp Cys Ala Val Lys Pro Cys Gln Ser Asp Glu Val Pro Asp Gly 
            100                 105                 110         


Ile Lys Ser Ala Ser Tyr Lys Tyr Ser Glu Glu Ala Asn Asn Leu Ile 
        115                 120                 125             


Glu Glu Cys Glu Gln Ala Glu Arg Leu Gly Ala Val Asp Glu Ser Leu 
    130                 135                 140                 


Ser Glu Glu Thr Gln Lys Ala Val Leu Gln Trp Thr Lys His Asp Asp 
145                 150                 155                 160 


Ser Ser Asp Asn Phe Cys Glu Ala Asp Asp Ile Gln Ser Pro Glu Ala 
                165                 170                 175     


Glu Tyr Val Asp Leu Leu Leu Asn Pro Glu Arg Tyr Thr Gly Tyr Lys 
            180                 185                 190         


Gly Pro Asp Ala Trp Lys Ile Trp Asn Val Ile Tyr Glu Glu Asn Cys 
        195                 200                 205             


Phe Lys Pro Gln Thr Ile Lys Arg Pro Leu Asn Pro Leu Ala Ser Gly 
    210                 215                 220                 


Gln Gly Thr Ser Glu Glu Asn Thr Phe Tyr Ser Trp Leu Glu Gly Leu 
225                 230                 235                 240 


Cys Val Glu Lys Arg Ala Phe Tyr Arg Leu Ile Ser Gly Leu His Ala 
                245                 250                 255     


Ser Ile Asn Val His Leu Ser Ala Arg Tyr Leu Leu Gln Glu Thr Trp 
            260                 265                 270         


Leu Glu Lys Lys Trp Gly His Asn Ile Thr Glu Phe Gln Gln Arg Phe 
        275                 280                 285             


Asp Gly Ile Leu Thr Glu Gly Glu Gly Pro Arg Arg Leu Lys Asn Leu 
    290                 295                 300                 


Tyr Phe Leu Tyr Leu Ile Glu Leu Arg Ala Leu Ser Lys Val Leu Pro 
305                 310                 315                 320 


Phe Phe Glu Arg Pro Asp Phe Gln Leu Phe Thr Gly Asn Lys Ile Gln 
                325                 330                 335     


Asp Glu Glu Asn Lys Met Leu Leu Leu Glu Ile Leu His Glu Ile Lys 
            340                 345                 350         


Ser Phe Pro Leu His Phe Asp Glu Asn Ser Phe Phe Ala Gly Asp Lys 
        355                 360                 365             


Lys Glu Ala His Lys Leu Lys Glu Asp Phe Arg Leu His Phe Arg Asn 
    370                 375                 380                 


Ile Ser Arg Ile Met Asp Cys Val Gly Cys Phe Lys Cys Arg Leu Trp 
385                 390                 395                 400 


Gly Lys Leu Gln Thr Gln Gly Leu Gly Thr Ala Leu Lys Ile Leu Phe 
                405                 410                 415     


Ser Glu Lys Leu Ile Ala Asn Met Pro Glu Ser Gly Pro Ser Tyr Glu 
            420                 425                 430         


Phe His Leu Thr Arg Gln Glu Ile Val Ser Leu Phe Asn Ala Phe Gly 
        435                 440                 445             


Arg Ile Ser Thr Ser Val Lys Glu Leu Glu Asn Phe Arg Asn Leu Leu 
    450                 455                 460                 


Gln Asn Ile His 
465             


<210>  3172
<211>  1907
<212>  DNA
<213>  Homosapiens

<400>  3172
ataagggaaa aaaactccat taaaaagccc agctttcctc catgttagat gtgacttgga     60

aaatgagaaa gatttagcaa aattccaccg tgtcttttgc caggctagag acagggagag    120

cagagtaaaa ccctcaggct gctgaaattt ctaggctgtt aggaagcccc tcgaattctg    180

tgaaaatgag ggtttcttaa ctcacactga gagcggaaag gggcagaccc ttttcataac    240

tccctcaagt gtgtgttacc tttctttacc agcatggtaa gcaacaggac atatcccagc    300

ctcggacatg tctgtatgat ccaaggtacc caaagtcaga cagagtaaac tcaagcctgg    360

cactggcttt ctgccgcttc atgtgctttg gaaaaagcag gagaagcaat agcagcagga    420

gtccccagca gctggagccg caagaatgaa ctgcaaagag ggaactgaca gcagctgcgg    480

ctgcaggggc aacgacgaga agaagatgtt gaagtgtgtg gtggtggggg acggtgccgt    540

ggggaaaacc tgcctgctga tgagctacgc caacgacgcc ttcccagagg aatacgtgcc    600

cactgtgttt gaccactatg cagttactgt gactgtggga ggcaagcaac acttgctcgg    660

actgtatgac accgcgggac aggaggacta caaccagctg aggccactct cctaccccaa    720

cacggatgtg tttttgatct gcttctctgt cgtaaaccct gcctcttacc acaatgtcca    780

ggaggaatgg gtccccgagc tcaaggactg catgcctcac gtgccttatg tcctcatagg    840

gacccagatt gatctccgtg atgacccaaa aaccttggcc cgtttgctgt atatgaaaga    900

gaaacctctc acttacgagc atggtgtgaa gctcgcaaaa gcgatcggag cacagtgcta    960

cttggaatgt tcagctctga ctcagaaagg tctcaaagcg gtttttgatg aagcaatcct   1020

caccattttc caccccaaga aaaagaagaa acgctgttct gagggtcaca gctgctgttc   1080

aattatctga ggttgtctgg gacctgcctc caccccatcc agggatgaga atggcagcca   1140

atctctgtgg ccaagctcca gccaaaaagg agggcacgac cagaaaggaa ctccctttgc   1200

acggaggctt gccccatcac cctctgagcc ctcccaacac agcacactag tcagcccact   1260

gccacgacct ccctgccagc cagaagcatc cgtactgcac gctgtctgag aatgctgggc   1320

ctggattgca gacagtgccg ctgctgatcg catcaaaaac aaagtcaaag gccatctcac   1380

attttacaaa tccccagctc atgaacgtga agctgatagg aaatcacccc agggaacccg   1440

aaaaagaaac ttgattcctc tattgctggc cttacttgat gtcttttata aaacttggga   1500

ctacaatact aacctttttt tctgaatctg ctgttctacc catgtgtctc acattcattt   1560

gtattatttc aagaaatgta ctaatttcca gttcactcag gccttactaa tccataccaa   1620

attagcctaa agacaaggca ttttatattc atttctattt tcagcatgtt tctaccaaag   1680

ctattagaac caacacgtac ctctgaatgc ccgattataa gaagacatga gaagacttta   1740

aaagttttgg aaatttacag agccatgatt tttgaaccta attgaaagaa aaccatctga   1800

attgttgcag gtccacattt ttgccaaaga tacactctat agatgcttag tagtggcctg   1860

atttttttcc atgtattgcc acgacaaact aaaaatgaac tgtgttt                 1907


<210>  3173
<211>  214
<212>  PRT
<213>  Homosapiens

<400>  3173

Met Asn Cys Lys Glu Gly Thr Asp Ser Ser Cys Gly Cys Arg Gly Asn 
1               5                   10                  15      


Asp Glu Lys Lys Met Leu Lys Cys Val Val Val Gly Asp Gly Ala Val 
            20                  25                  30          


Gly Lys Thr Cys Leu Leu Met Ser Tyr Ala Asn Asp Ala Phe Pro Glu 
        35                  40                  45              


Glu Tyr Val Pro Thr Val Phe Asp His Tyr Ala Val Thr Val Thr Val 
    50                  55                  60                  


Gly Gly Lys Gln His Leu Leu Gly Leu Tyr Asp Thr Ala Gly Gln Glu 
65                  70                  75                  80  


Asp Tyr Asn Gln Leu Arg Pro Leu Ser Tyr Pro Asn Thr Asp Val Phe 
                85                  90                  95      


Leu Ile Cys Phe Ser Val Val Asn Pro Ala Ser Tyr His Asn Val Gln 
            100                 105                 110         


Glu Glu Trp Val Pro Glu Leu Lys Asp Cys Met Pro His Val Pro Tyr 
        115                 120                 125             


Val Leu Ile Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Lys Thr Leu 
    130                 135                 140                 


Ala Arg Leu Leu Tyr Met Lys Glu Lys Pro Leu Thr Tyr Glu His Gly 
145                 150                 155                 160 


Val Lys Leu Ala Lys Ala Ile Gly Ala Gln Cys Tyr Leu Glu Cys Ser 
                165                 170                 175     


Ala Leu Thr Gln Lys Gly Leu Lys Ala Val Phe Asp Glu Ala Ile Leu 
            180                 185                 190         


Thr Ile Phe His Pro Lys Lys Lys Lys Lys Arg Cys Ser Glu Gly His 
        195                 200                 205             


Ser Cys Cys Ser Ile Ile 
    210                 


<210>  3174
<211>  392
<212>  DNA
<213>  Homosapiens

<400>  3174
atgaagctgg cattcctctt ccttggcccc atggccctcc tccttctggc tggctatggc     60

tgtgtcctcg gtgcctccag tgggaacctg cgcacctttg tgggctgtgc cgtgagggag    120

tttactttcc tggccaagaa gccaggctgc aggggcttcg gatcaccacg gatgcctgct    180

ggggtcgctg tgagacctgg cagaaaccca ttctggaacc cccctatatt gaagcccatc    240

atcgagtctg tacctacaac gagaccaaac aggtgactgt caagctgccc aactgtgccc    300

cgggagtcga ccccttctac acctatcccg tggccatccg ctgtgactgc ggagcctgct    360

ccactgccac cacggagtgt gagaccatct ga                                  392


<210>  3175
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  3175

Met Lys Leu Ala Phe Leu Phe Leu Gly Pro Met Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Gly Tyr Gly Cys Val Leu Gly Ala Ser Ser Gly Asn Leu Arg Thr 
            20                  25                  30          


Phe Val Gly Cys Ala Val Arg Glu Phe Thr Phe Leu Ala Lys Lys Pro 
        35                  40                  45              


Gly Cys Arg Gly Phe Gly Ser Pro Arg Met Pro Ala Gly Val Ala Val 
    50                  55                  60                  


Arg Pro Gly Arg Asn Pro Phe Trp Asn Pro Pro Ile Leu Lys Pro Ile 
65                  70                  75                  80  


Ile Glu Ser Val Pro Thr Thr Arg Pro Asn Arg 
                85                  90      


<210>  3176
<211>  3366
<212>  DNA
<213>  Homosapiens

<400>  3176
ggttgcgcgt gtgccatgga ctcagccgcc cggtgatatt gacaatagga gagagaaagg     60

ggcattgact gggacccacc gcgggtagcg aaaggtggct ctggcagcgg cggctccagc    120

tcctgcggct cctcctcctt attctgtccc cttctcttgc tgccgctgca gatccagtct    180

tcctccctcc cttccccccc tccccacgtc gtcgccgccg ccgccgggtc cggggcaacg    240

agctgaggcg ccgcccgcca ggaatgtgag cgaggagcca ccggcggagc cgcaacgggg    300

tcggtgccga tttgatggga cgggcccgcg ggggaggatc gtgaggccgc cgccgccacc    360

ggaacgctga ggttcgggtc cggccgtgag gcctagaggc tccgccgccg cggaaccgga    420

gggaccccgt accggacagc cgtcgcccca ggctccccgc agctgcccgg acctccccct    480

gcacgtcccg gtcccgccgc ccgcccccgc tgcggccacc tcgcccgtct cccgcccctc    540

caagccacag atcatctttg gattcttccc cagaagcttc aagtagggat atgtcctcag    600

caccaactac tcctccatca gtggataaag tagacggatt ttctcggaag tccgtcagaa    660

aagccagaca gaagaggtcg caaagttcct cacagtttag gtctcaaggc aagcctattg    720

agttaacacc tctgccgctg ctaaaagacg ttccatcctc agagcagcct gaactgttcc    780

taaagaaact tcagcagtgc tgtgtcattt ttgacttcat ggacacgcta tctgatctta    840

aaatgaaaga atacaagcgc tccactctta atgaactggt ggactacatt acaataagca    900

gaggctgttt gacagagcag acttaccctg aagtagttag aatggtatct tgcaatatat    960

tcagaactct ccctcctagt gacagcaatg aatttgatcc agaagaagat gaacctaccc   1020

ttgaggcatc gtggccacac ttacagcttg tatatgaatt tttcatacga tttttggaaa   1080

gccaagaatt ccaacccagc attgccaaaa aatatataga tcagaaattt gtattacagc   1140

ttctggagct atttgacagc gaagaccctc gggaacggga ctacttaaaa acagtcttac   1200

acagaattta tggcaagttt cttggtctta gagcatttat ccgaaaacag attaacaata   1260

tttttctaag gtttgtttat gaaacagaac acttcaatgg tgtagctgaa ctgctggaaa   1320

tattaggaag tattatcaat ggctttgctt tacctcttaa ggcagaacac aaacagtttc   1380

tggtgaaagt attgatccct ttacacactg tcaggagctt atcactcttc catgcacagc   1440

tggcatattg tatagtacag tttctggaga aagatccttc actcacagaa ccagttatta   1500

gggggttaat gaaattttgg cctaaaacat gtagtcaaaa agaggtcatg ttccttgggg   1560

aactggaaga aatattggat gtgattgaac cttcacaatt tgttaaaatc caagaacctt   1620

tgtttaaaca aatcgccaag tgtgtatcta gcccccattt tcaggtggca gaaagagcac   1680

tctattattg gaataatgaa tacatcatga gtttgataga agaaaactct aacgtcatcc   1740

ttcccatcat gttttccagc ctttatagga tttcaaaaga acattggaat ccggctattg   1800

tggcgttggt gtacaatgtg ttgaaggcat ttatggaaat gaacagcacc atgtttgacg   1860

agctgacagc cacatacaag tcagatcgtc agcgtgagaa aaagaaagaa aaggagcgtg   1920

aagaattgtg gaaaaaattg gaggatctgg agttaaagag aggtcttaga cgtgatggaa   1980

taattccaac ttaacaaaaa caatgacaac aacattacta acctgtggag tcacacgttt   2040

atgtagtaga agatggagca acagttttct gtattgtgca actttacagt agatttcacc   2100

tttgtttcat tattacagca gcactgtata tacctgtctc taagtaaagg aaaaaacaaa   2160

ataaggactt caatccaaag tttggacagt agatggactt ctcagaactt tgcaaacata   2220

atcattgttc tcaccctctt ttaaaaaaaa aaatcggtct tcaaagatct gttgatgaaa   2280

ttgctatgtt aaaattccat tatcgggagt tccttattta tcactagcag agagtatgat   2340

acaattttca aatgtgaaca atcttaaatt tagcttgtct ttctgctaag ctgttaaatg   2400

tatttatagt aaaggaagaa aaaaagactg tcatttcctt ataagtttgt gtaacatcct   2460

cctctggata acttgactgt aatttaacat ctttttcttt tgcacatctt cctgagttga   2520

atgtccacgt ggaatggggt catgaattat aaaagtccct gataaaagtt ttgtttactg   2580

gggtgaacat ctttccagta accaggtagt cctggtactc ctttagtttt aaaattagga   2640

gttaagagag aagaggtgat aaacatagta gggaagggaa tatcggattc atgcatcagt   2700

ttatggtgaa tccaaatcaa tgtcttgaat cctttgaaaa caggcactgg gacatcacag   2760

gcttcagtac ctgaccagta ttagttgcat atatcattga acacacatac cagagatgtt   2820

ttagaaatgt gagaaaaaca tccttttgga ccatttgaaa taagaaagac aaacactaaa   2880

caatacaacc atgaaattga tcaccgggat tgcaaatcta attgggaaaa gagttgagca   2940

aacagcttgg actgtttgga gttgttgcct tactttttaa tatgtattta taaagtattc   3000

cagcaaaaga ggatgtagcc tctgggaaaa aacaaacatg ttacagtgtt ttttgtagat   3060

tctcgttcta tatctcatca cagcgccagc cctgttttta gccggaaagg attcaggata   3120

aacattatta tgcattctga attggatgca tattcctaac tactgtattt gttaccaaaa   3180

gtggttctac aaatgctact gaaaaaaatc tggaaattcc taatgtcctg agtattaata   3240

ataaagttta aaaatgcttt tatatcaaag gtgcatcgtg accaaattgt ttaagaaaaa   3300

aaaacaaaaa aaacaaaatc tagggctgta ttttatatat atatatatat atatatatat   3360

atatat                                                              3366


<210>  3177
<211>  467
<212>  PRT
<213>  Homosapiens

<400>  3177

Met Ser Ser Ala Pro Thr Thr Pro Pro Ser Val Asp Lys Val Asp Gly 
1               5                   10                  15      


Phe Ser Arg Lys Ser Val Arg Lys Ala Arg Gln Lys Arg Ser Gln Ser 
            20                  25                  30          


Ser Ser Gln Phe Arg Ser Gln Gly Lys Pro Ile Glu Leu Thr Pro Leu 
        35                  40                  45              


Pro Leu Leu Lys Asp Val Pro Ser Ser Glu Gln Pro Glu Leu Phe Leu 
    50                  55                  60                  


Lys Lys Leu Gln Gln Cys Cys Val Ile Phe Asp Phe Met Asp Thr Leu 
65                  70                  75                  80  


Ser Asp Leu Lys Met Lys Glu Tyr Lys Arg Ser Thr Leu Asn Glu Leu 
                85                  90                  95      


Val Asp Tyr Ile Thr Ile Ser Arg Gly Cys Leu Thr Glu Gln Thr Tyr 
            100                 105                 110         


Pro Glu Val Val Arg Met Val Ser Cys Asn Ile Phe Arg Thr Leu Pro 
        115                 120                 125             


Pro Ser Asp Ser Asn Glu Phe Asp Pro Glu Glu Asp Glu Pro Thr Leu 
    130                 135                 140                 


Glu Ala Ser Trp Pro His Leu Gln Leu Val Tyr Glu Phe Phe Ile Arg 
145                 150                 155                 160 


Phe Leu Glu Ser Gln Glu Phe Gln Pro Ser Ile Ala Lys Lys Tyr Ile 
                165                 170                 175     


Asp Gln Lys Phe Val Leu Gln Leu Leu Glu Leu Phe Asp Ser Glu Asp 
            180                 185                 190         


Pro Arg Glu Arg Asp Tyr Leu Lys Thr Val Leu His Arg Ile Tyr Gly 
        195                 200                 205             


Lys Phe Leu Gly Leu Arg Ala Phe Ile Arg Lys Gln Ile Asn Asn Ile 
    210                 215                 220                 


Phe Leu Arg Phe Val Tyr Glu Thr Glu His Phe Asn Gly Val Ala Glu 
225                 230                 235                 240 


Leu Leu Glu Ile Leu Gly Ser Ile Ile Asn Gly Phe Ala Leu Pro Leu 
                245                 250                 255     


Lys Ala Glu His Lys Gln Phe Leu Val Lys Val Leu Ile Pro Leu His 
            260                 265                 270         


Thr Val Arg Ser Leu Ser Leu Phe His Ala Gln Leu Ala Tyr Cys Ile 
        275                 280                 285             


Val Gln Phe Leu Glu Lys Asp Pro Ser Leu Thr Glu Pro Val Ile Arg 
    290                 295                 300                 


Gly Leu Met Lys Phe Trp Pro Lys Thr Cys Ser Gln Lys Glu Val Met 
305                 310                 315                 320 


Phe Leu Gly Glu Leu Glu Glu Ile Leu Asp Val Ile Glu Pro Ser Gln 
                325                 330                 335     


Phe Val Lys Ile Gln Glu Pro Leu Phe Lys Gln Ile Ala Lys Cys Val 
            340                 345                 350         


Ser Ser Pro His Phe Gln Val Ala Glu Arg Ala Leu Tyr Tyr Trp Asn 
        355                 360                 365             


Asn Glu Tyr Ile Met Ser Leu Ile Glu Glu Asn Ser Asn Val Ile Leu 
    370                 375                 380                 


Pro Ile Met Phe Ser Ser Leu Tyr Arg Ile Ser Lys Glu His Trp Asn 
385                 390                 395                 400 


Pro Ala Ile Val Ala Leu Val Tyr Asn Val Leu Lys Ala Phe Met Glu 
                405                 410                 415     


Met Asn Ser Thr Met Phe Asp Glu Leu Thr Ala Thr Tyr Lys Ser Asp 
            420                 425                 430         


Arg Gln Arg Glu Lys Lys Lys Glu Lys Glu Arg Glu Glu Leu Trp Lys 
        435                 440                 445             


Lys Leu Glu Asp Leu Glu Leu Lys Arg Gly Leu Arg Arg Asp Gly Ile 
    450                 455                 460                 


Ile Pro Thr 
465         


<210>  3178
<211>  3164
<212>  DNA
<213>  Homosapiens

<400>  3178
gccagaaagc agattttcac ttgggaagag acgacccgta gtatgggatg tggtatgata     60

ccagcaactg gtctattata tcatttaaac cacatggcta tctaaagagg tatttggcta    120

ttataaataa aatagtgatg aacacgtgta caggtgtttg tacggacata agttgtcatt    180

tctcttgagt aaatacctaa aagtgggctt gctggagttt tactaccctt ggatgctgct    240

gttgacatgg aaaagattga ggaacaattt gctaatctgc acattgttaa atgttcctta    300

ggaaccaaag agcccactta ccttcttggt atagacacat caaagactgt ccaagcagga    360

aaggaaaact tggttgctgt tttatgttct aatggatcaa tcagaatata tgataaagaa    420

aggttaaatg tactacgaga atttagtgga tatcctggac ttcttaatgg agtcagattt    480

gcaaattcct gtgacagtgt atattcagca tgtactgatg gcactgtgaa atgctgggat    540

gctcgagtag ccagagaaaa acctgttcag ctcttcaagg gttacccttc caatattttt    600

atcagttttg atattaattg taatgatcat attatttgtg ctggtacaga aaaagttgat    660

gatgatgcat tgttggtgtt ttgggatgca aggatgaatt ctcagaattt atctacaact    720

aaagactcac ttggtgcata ttcagagaca catagtgatg atgtcactca agtacgtttc    780

catcccagca atcccaacat ggtagtctca ggttcatctg atggcctggt aaatgtattt    840

gatattaata ttgataatga ggaggatgca ctggttacaa cctgtaactc aatttcatca    900

gtaagctgta ttggttggtc tgggaaaggt tataaacaga tttactgcat gacacatgat    960

gaaggatttt attggtggga tcttaatcat ctggacactg atgaaccagt tacacgtttg   1020

aacatccagg atgtcagaga agtagttaac atgaaagaag atgctttgga ctatttgatt   1080

ggtggcctat atcatgaaaa gacagacaca ttgcatgtta ttggaggaac aaacaaagga   1140

aggattcatt tgatgaactg cagcatgtca ggactgaccc atgtgactag ccttcaggga   1200

gggcatgctg ctacagtccg ttctttctgt tggaatgtgc aagatgattc tttgttgact   1260

ggaggagaag atgcacagtt gttactttgg aaacctggag ctatagagaa gacctttaca   1320

aagaaagaga gtatgaaaat agcatcctct gtgcaccaac gagtacgagt tcatagtaat   1380

gattcttata aaagaaggaa aaagcagtga taatgcattt ggcactttgt ttggtaggtt   1440

ttatagtttc aaatagtcct tcttgtttac tacccatggt agacatgttt aaagctttat   1500

gtaaaaacaa gccagttagc aaacagtcct ggaaaaatat ggtgagaatg gtttaattcc   1560

ggtcttcaca tattctaaaa aattttaaag cctctaagta taaaatcagt gagttgaaag   1620

taaaatttct tatttaaaga acccatctgt taatgtagta aatgttggct ttaaagaaat   1680

agctccgata aggacttttt agaaggaaat acttggtaaa acttaataaa acaggtggtt   1740

ggctgcattt tttaagccca gttttttaca ttttaaattg tctttattgt gtataaaacc   1800

agattagact atattcttca tctgaggagc atctatatgt ttaatacacc taatgtatta   1860

tgctggagta tttaaatgta agtattttaa tgagtaaata gaattaacct tttttacaaa   1920

tgaaatgata ggcatctatg taaagtgaga aaaatatgtt tcgtaaatat ttgcatcttt   1980

aatattgtta gtaagtagta aacaggtgtt ttgctgattg aaaggaagtt atcttggtaa   2040

attgagactc aaagtgaaat acaaaaatga aaatatttat aataggactc gacttggaga   2100

aattgctatt cttcctgttg tccaaaccat aaatctgagg ataacctggg cttttctctt   2160

tcctcttctc ctaaccagtt tttcaccaag tcctgtgcca tttcacctcc taacgtctgt   2220

cagctatcct tttgccttta cctcaccact attaccctag agaagacttt cattatttct   2280

catctggatt accagctcga tctctaatct gcttcagttc atccttcttg ctacttctag   2340

gctaaacatc aaaaacagat ctggtagggg cggggaaatg agggggaaga aacaaaaacg   2400

tgatggtgcc tcatgctgct taaaatcttc agtacattga tgttttgatg gcggactaca   2460

taagcgttaa aaattgtgtt tttcagaatc tttaaaatat aagacagtgc tatctagtga   2520

ataaaaaaat tagtttgaaa gatatctgga gaaatcgcat tcataaaaca attggaagtg   2580

aaactattaa aacaataggg ctttttaaaa ttaaaaatat ttaaaattca aaagtaatta   2640

atagtgttgg aagatgtagg tgagaaaata ttcctgaaag tagaactgaa agagacaaag   2700

agaaaagatg aaagccacag aagataaata caggggtcaa aaccagacta acagttttag   2760

aaagtgaaaa aagttaaaaa agaaatgggg gcagtgggtt attagaaata acataaatgg   2820

ctggtatggt ttgtctgtgt cctcacccaa atttcatctc gaattgtaat ccccataatc   2880

cccatgtgtc tagggagaga cctggtggga ggtgattgga tcatgggggt ggtttcccct   2940

acgatgttct cctgatagtg ggtgagttct cacaagatct gatggtttta taaagggctc   3000

tgccccttta actcctcact ctttctcctg aagccttgtg aagaaggtgc tttgcttccc   3060

ctttgcgttc ccccatgatt gtaagtttct tgaggcctcc ctggccatgc tgaactcttc   3120

agtcaattaa acactttcct ttataaatta aaaaaaaaaa aaaa                    3164


<210>  3179
<211>  387
<212>  PRT
<213>  Homosapiens

<400>  3179

Met Glu Lys Ile Glu Glu Gln Phe Ala Asn Leu His Ile Val Lys Cys 
1               5                   10                  15      


Ser Leu Gly Thr Lys Glu Pro Thr Tyr Leu Leu Gly Ile Asp Thr Ser 
            20                  25                  30          


Lys Thr Val Gln Ala Gly Lys Glu Asn Leu Val Ala Val Leu Cys Ser 
        35                  40                  45              


Asn Gly Ser Ile Arg Ile Tyr Asp Lys Glu Arg Leu Asn Val Leu Arg 
    50                  55                  60                  


Glu Phe Ser Gly Tyr Pro Gly Leu Leu Asn Gly Val Arg Phe Ala Asn 
65                  70                  75                  80  


Ser Cys Asp Ser Val Tyr Ser Ala Cys Thr Asp Gly Thr Val Lys Cys 
                85                  90                  95      


Trp Asp Ala Arg Val Ala Arg Glu Lys Pro Val Gln Leu Phe Lys Gly 
            100                 105                 110         


Tyr Pro Ser Asn Ile Phe Ile Ser Phe Asp Ile Asn Cys Asn Asp His 
        115                 120                 125             


Ile Ile Cys Ala Gly Thr Glu Lys Val Asp Asp Asp Ala Leu Leu Val 
    130                 135                 140                 


Phe Trp Asp Ala Arg Met Asn Ser Gln Asn Leu Ser Thr Thr Lys Asp 
145                 150                 155                 160 


Ser Leu Gly Ala Tyr Ser Glu Thr His Ser Asp Asp Val Thr Gln Val 
                165                 170                 175     


Arg Phe His Pro Ser Asn Pro Asn Met Val Val Ser Gly Ser Ser Asp 
            180                 185                 190         


Gly Leu Val Asn Val Phe Asp Ile Asn Ile Asp Asn Glu Glu Asp Ala 
        195                 200                 205             


Leu Val Thr Thr Cys Asn Ser Ile Ser Ser Val Ser Cys Ile Gly Trp 
    210                 215                 220                 


Ser Gly Lys Gly Tyr Lys Gln Ile Tyr Cys Met Thr His Asp Glu Gly 
225                 230                 235                 240 


Phe Tyr Trp Trp Asp Leu Asn His Leu Asp Thr Asp Glu Pro Val Thr 
                245                 250                 255     


Arg Leu Asn Ile Gln Asp Val Arg Glu Val Val Asn Met Lys Glu Asp 
            260                 265                 270         


Ala Leu Asp Tyr Leu Ile Gly Gly Leu Tyr His Glu Lys Thr Asp Thr 
        275                 280                 285             


Leu His Val Ile Gly Gly Thr Asn Lys Gly Arg Ile His Leu Met Asn 
    290                 295                 300                 


Cys Ser Met Ser Gly Leu Thr His Val Thr Ser Leu Gln Gly Gly His 
305                 310                 315                 320 


Ala Ala Thr Val Arg Ser Phe Cys Trp Asn Val Gln Asp Asp Ser Leu 
                325                 330                 335     


Leu Thr Gly Gly Glu Asp Ala Gln Leu Leu Leu Trp Lys Pro Gly Ala 
            340                 345                 350         


Ile Glu Lys Thr Phe Thr Lys Lys Glu Ser Met Lys Ile Ala Ser Ser 
        355                 360                 365             


Val His Gln Arg Val Arg Val His Ser Asn Asp Ser Tyr Lys Arg Arg 
    370                 375                 380                 


Lys Lys Gln 
385         


<210>  3180
<211>  3125
<212>  DNA
<213>  Homosapiens

<400>  3180
gggttccact tgaccgctct aagccgccgc gcagcctgcg ttttctccgg tacaggttga     60

ggctactaag gtatttggct attataaata aaatagtgat gaacacgtgt acaggtgttt    120

gtacggacat aagttgtcat ttctcttgag taaataccta aaagtgggct tgctggagtt    180

ttactaccct tggatgctgc tgttgacatg gaaaagattg aggaacaatt tgctaatctg    240

cacattgtta aatgttcctt aggaaccaaa gagcccactt accttcttgg tatagacaca    300

tcaaagactg tccaagcagg aaaggaaaac ttggttgctg ttttatgttc taatggatca    360

atcagaatat atgataaaga aaggttaaat gtactacgag aatttagtgg atatcctgga    420

cttcttaatg gagtcagatt tgcaaattcc tgtgacagtg tatattcagc atgtactgat    480

ggcactgtga aatgctggga tgctcgagta gccagagaaa aacctgttca gctcttcaag    540

ggttaccctt ccaatatttt tatcagtttt gatattaatt gtaatgatca tattatttgt    600

gctggtacag aaaaagttga tgatgatgca ttgttggtgt tttgggatgc aaggatgaat    660

tctcagaatt tatctacaac taaagactca cttggtgcat attcagagac acatagtgat    720

gatgtcactc aagtacgttt ccatcccagc aatcccaaca tggtagtctc aggttcatct    780

gatggcctgg taaatgtatt tgatattaat attgataatg aggaggatgc actggttaca    840

acctgtaact caatttcatc agtaagctgt attggttggt ctgggaaagg ttataaacag    900

atttactgca tgacacatga tgaaggattt tattggtggg atcttaatca tctggacact    960

gatgaaccag ttacacgttt gaacatccag gatgtcagag aagtagttaa catgaaagaa   1020

gatgctttgg actatttgat tggtggccta tatcatgaaa agacagacac attgcatgtt   1080

attggaggaa caaacaaagg aaggattcat ttgatgaact gcagcatgtc aggactgacc   1140

catgtgacta gccttcaggg agggcatgct gctacagtcc gttctttctg ttggaatgtg   1200

caagatgatt ctttgttgac tggaggagaa gatgcacagt tgttactttg gaaacctgga   1260

gctatagaga agacctttac aaagaaagag agtatgaaaa tagcatcctc tgtgcaccaa   1320

cgagtacgag ttcatagtaa tgattcttat aaaagaagga aaaagcagtg ataatgcatt   1380

tggcactttg tttggtaggt tttatagttt caaatagtcc ttcttgttta ctacccatgg   1440

tagacatgtt taaagcttta tgtaaaaaca agccagttag caaacagtcc tggaaaaata   1500

tggtgagaat ggtttaattc cggtcttcac atattctaaa aaattttaaa gcctctaagt   1560

ataaaatcag tgagttgaaa gtaaaatttc ttatttaaag aacccatctg ttaatgtagt   1620

aaatgttggc tttaaagaaa tagctccgat aaggactttt tagaaggaaa tacttggtaa   1680

aacttaataa aacaggtggt tggctgcatt ttttaagccc agttttttac attttaaatt   1740

gtctttattg tgtataaaac cagattagac tatattcttc atctgaggag catctatatg   1800

tttaatacac ctaatgtatt atgctggagt atttaaatgt aagtatttta atgagtaaat   1860

agaattaacc ttttttacaa atgaaatgat aggcatctat gtaaagtgag aaaaatatgt   1920

ttcgtaaata tttgcatctt taatattgtt agtaagtagt aaacaggtgt tttgctgatt   1980

gaaaggaagt tatcttggta aattgagact caaagtgaaa tacaaaaatg aaaatattta   2040

taataggact cgacttggag aaattgctat tcttcctgtt gtccaaacca taaatctgag   2100

gataacctgg gcttttctct ttcctcttct cctaaccagt ttttcaccaa gtcctgtgcc   2160

atttcacctc ctaacgtctg tcagctatcc ttttgccttt acctcaccac tattacccta   2220

gagaagactt tcattatttc tcatctggat taccagctcg atctctaatc tgcttcagtt   2280

catccttctt gctacttcta ggctaaacat caaaaacaga tctggtaggg gcggggaaat   2340

gagggggaag aaacaaaaac gtgatggtgc ctcatgctgc ttaaaatctt cagtacattg   2400

atgttttgat ggcggactac ataagcgtta aaaattgtgt ttttcagaat ctttaaaata   2460

taagacagtg ctatctagtg aataaaaaaa ttagtttgaa agatatctgg agaaatcgca   2520

ttcataaaac aattggaagt gaaactatta aaacaatagg gctttttaaa attaaaaata   2580

tttaaaattc aaaagtaatt aatagtgttg gaagatgtag gtgagaaaat attcctgaaa   2640

gtagaactga aagagacaaa gagaaaagat gaaagccaca gaagataaat acaggggtca   2700

aaaccagact aacagtttta gaaagtgaaa aaagttaaaa aagaaatggg ggcagtgggt   2760

tattagaaat aacataaatg gctggtatgg tttgtctgtg tcctcaccca aatttcatct   2820

cgaattgtaa tccccataat ccccatgtgt ctagggagag acctggtggg aggtgattgg   2880

atcatggggg tggtttcccc tacgatgttc tcctgatagt gggtgagttc tcacaagatc   2940

tgatggtttt ataaagggct ctgccccttt aactcctcac tctttctcct gaagccttgt   3000

gaagaaggtg ctttgcttcc cctttgcgtt cccccatgat tgtaagtttc ttgaggcctc   3060

cctggccatg ctgaactctt cagtcaatta aacactttcc tttataaatt aaaaaaaaaa   3120

aaaaa                                                               3125


<210>  3181
<211>  387
<212>  PRT
<213>  Homosapiens

<400>  3181

Met Glu Lys Ile Glu Glu Gln Phe Ala Asn Leu His Ile Val Lys Cys 
1               5                   10                  15      


Ser Leu Gly Thr Lys Glu Pro Thr Tyr Leu Leu Gly Ile Asp Thr Ser 
            20                  25                  30          


Lys Thr Val Gln Ala Gly Lys Glu Asn Leu Val Ala Val Leu Cys Ser 
        35                  40                  45              


Asn Gly Ser Ile Arg Ile Tyr Asp Lys Glu Arg Leu Asn Val Leu Arg 
    50                  55                  60                  


Glu Phe Ser Gly Tyr Pro Gly Leu Leu Asn Gly Val Arg Phe Ala Asn 
65                  70                  75                  80  


Ser Cys Asp Ser Val Tyr Ser Ala Cys Thr Asp Gly Thr Val Lys Cys 
                85                  90                  95      


Trp Asp Ala Arg Val Ala Arg Glu Lys Pro Val Gln Leu Phe Lys Gly 
            100                 105                 110         


Tyr Pro Ser Asn Ile Phe Ile Ser Phe Asp Ile Asn Cys Asn Asp His 
        115                 120                 125             


Ile Ile Cys Ala Gly Thr Glu Lys Val Asp Asp Asp Ala Leu Leu Val 
    130                 135                 140                 


Phe Trp Asp Ala Arg Met Asn Ser Gln Asn Leu Ser Thr Thr Lys Asp 
145                 150                 155                 160 


Ser Leu Gly Ala Tyr Ser Glu Thr His Ser Asp Asp Val Thr Gln Val 
                165                 170                 175     


Arg Phe His Pro Ser Asn Pro Asn Met Val Val Ser Gly Ser Ser Asp 
            180                 185                 190         


Gly Leu Val Asn Val Phe Asp Ile Asn Ile Asp Asn Glu Glu Asp Ala 
        195                 200                 205             


Leu Val Thr Thr Cys Asn Ser Ile Ser Ser Val Ser Cys Ile Gly Trp 
    210                 215                 220                 


Ser Gly Lys Gly Tyr Lys Gln Ile Tyr Cys Met Thr His Asp Glu Gly 
225                 230                 235                 240 


Phe Tyr Trp Trp Asp Leu Asn His Leu Asp Thr Asp Glu Pro Val Thr 
                245                 250                 255     


Arg Leu Asn Ile Gln Asp Val Arg Glu Val Val Asn Met Lys Glu Asp 
            260                 265                 270         


Ala Leu Asp Tyr Leu Ile Gly Gly Leu Tyr His Glu Lys Thr Asp Thr 
        275                 280                 285             


Leu His Val Ile Gly Gly Thr Asn Lys Gly Arg Ile His Leu Met Asn 
    290                 295                 300                 


Cys Ser Met Ser Gly Leu Thr His Val Thr Ser Leu Gln Gly Gly His 
305                 310                 315                 320 


Ala Ala Thr Val Arg Ser Phe Cys Trp Asn Val Gln Asp Asp Ser Leu 
                325                 330                 335     


Leu Thr Gly Gly Glu Asp Ala Gln Leu Leu Leu Trp Lys Pro Gly Ala 
            340                 345                 350         


Ile Glu Lys Thr Phe Thr Lys Lys Glu Ser Met Lys Ile Ala Ser Ser 
        355                 360                 365             


Val His Gln Arg Val Arg Val His Ser Asn Asp Ser Tyr Lys Arg Arg 
    370                 375                 380                 


Lys Lys Gln 
385         


<210>  3182
<211>  3323
<212>  DNA
<213>  Homosapiens

<400>  3182
gcgctgtgcc ggttccgctg ccgctggcca ggagcgcggg gacagttcgg ggctgcgccg     60

gaggccggcc cgccttcccg ggggttccgt tatcatgtcg ctgaggcagc gcctggccca    120

gctggttggc cgtctgcagg acccgcagaa agtggcccgt ttccagcggc tgtgcggggt    180

ggaagcgccg ccgcgccgct cagcagaccg gagggaggat gagaaagcgg aggcgcctct    240

cgccggagac cctcgactgc gagggcggca gccaggggcg cctggaggcc cccagcctcc    300

cgggagcgac cgcaatcagt gcccggccaa gccggacggc ggcggcgccc ccaacggcgt    360

gcggaacggg ctggcggccg agctgggccc ggcctcgccg cggcgcgcgg gcgctctgcg    420

ccgcaactcg ctgacgggcg aggagggcca gctggcccgc gtgagcaact ggccgctcta    480

ctgcctgttc tgcttcggca cggagctggg caacgaactc ttctacatcc tgttcttccc    540

cttctggatc tggaacctgg accctctggt gggccggagg ctcgtggtca tctgggtgct    600

ggtcatgtac ctgggccagt gcaccaagga catcatccgc tggccgaggc ccgcctcgcc    660

gcccgtggtc aagttggagg tcttctacaa ctctgagtac agcatgccct ccacccatgc    720

catgtccggc accgccatcc ccatttctat ggtcctcctc acctatggcc gctggcagta    780

ccctcttata tatggactga ttcttattcc ctgctggtgt tctctagttt gcctaagtag    840

aatttacatg ggaatgcact ctattctgga tattattgct ggattcctat ataccatttt    900

aatcttagct gtcttctatc catttgtgga cctgattgac aacttcaacc aaactcacaa    960

atatgctcca ttcatcatca tcgggcttca tttagctttg gggatctttt ctttcactct   1020

tgacacctgg agcacatccc gaggagacac agccgagata ctaggaagtg gtgctggaat   1080

tgcatgtgga tctcatgtta cttataacat gggtctagta ttagatcctt ctctagatac   1140

attaccttta gctgggcccc ccattactgt gactctgttt ggaaaagcca tattgcggat   1200

cctcataggg atggtatttg tactaataat cagagatgta atgaaaaaga tcaccattcc   1260

tttagcctgc aaaatcttca atataccgtg tgatgatatt cgaaaagcaa gacagcacat   1320

ggaagttgaa cttccttatc ggtatattac ctatggaatg gttggtttct ccatcacatt   1380

ttttgttcct tacatatttt tctttattgg tatctcttga tggagaagta ttgtttatga   1440

taagaaagga gggtatcagt tactgatacc caaaaatata ttccaggtaa agccaggtca   1500

gaattaggct tttgcaggaa tttaacttaa ataattattt aagtaaattc ataagagtca   1560

gtgcatttta tcattgcaca tccagatact gttttaggtg agctgagcta tttcgttact   1620

gagaaaatga taagtatcca tttagaatgt tcatgtaatg tttggagagt tttgtattat   1680

ggattcaact tatatataat atatataagg tacataatat gcaattatgt atctgatata   1740

tattatatat aaaataatat acctaagtgt ttttttaaac tatgggagtg tattataaaa   1800

tcaataataa tatgcaaaca gttgtgcctg tgtatttgaa ctacatacag gtatgttgtt   1860

attaacagat atatttaaca tttatttact atgggagcca tttcctaatt gaattgcgta   1920

attactagac cagaatgcat atgctactat acattgattt actgcctgtt tttacactgc   1980

cattaccttt catgttatcc atgatgttga acatgggagg catttttaat ggaccaaatt   2040

tttagaaaaa ttagtttttg gatttttttt taagttctgt atactgtttt gaatgaactt   2100

tatttgcagc tattctggat gtcagtttaa taattcaggt actgaatttt attgcttgct   2160

aattgtgcct ttccgttgct aaattaagaa atgctatgtg tactgtgatg taaaaataag   2220

acattaactt tatcttaagt tacatataat caagcaaata ttttaaaaaa tgtatgtcag   2280

ggtgacaggc ataaaagtaa attaccctta actctttagc ctttatttag aaagaaatgt   2340

ggaatgggct aaactttctc accaatttat tagaaagcta aatggataaa tacttccctt   2400

tttgtagata tttttctgtg cattgtaagt tataggagca ggacatattt tttgtacatt   2460

gtcttgattg tttatactgc aggtaggtat ttccagtgaa tggaaacgtt gaaatttata   2520

gatgggacaa tgcacatact tcatatgtaa acaaagcatt tttctaaata atttggaaag   2580

gattggattt agcaccgtta acttttaata cccatttatt ggctatttaa ggtaaattat   2640

aaaacctaaa attagtatca gtattttaga tcctattatt ttttcaactt tctattattt   2700

tcacagtgga aaatttgcgt atagtattaa actattcttt tttctgtcta cctttatatt   2760

ttgaagtgtg gttgtactta cgttaatagt aagtgtattt gtagaaagtt tttcataaag   2820

aagagattaa ctttccatat aaataaatac caggtatgaa attactgatt ttagtgcaat   2880

atctgtatga ttatccagaa ctatcacttc agatgtttct attttgggca ccataactat   2940

ttgagctcat atttttataa ttctgattga gaatttaggg gcatggtaat ttttaccaaa   3000

actgaagctg gtaattttaa gtaaagcaac taaatttacc ctttacttat tagttaaaag   3060

gaaaccaagg catgtaggaa aatattggta cgttggaaaa tgtgaaaaga gctttacttt   3120

caaaatgtat gtttaatgaa ttgaatttta gggaccgttt cccataattt gggcctatgc   3180

tatcctgttg atttttatgt ctagcttaaa aggtatttga aaatgttcca tttgtgtttt   3240

attattttct gtcctatgac agttctatgc taaatgtatt ttaaaataaa agccaaattg   3300

aagattaaaa aaaaaaaaaa aaa                                           3323


<210>  3183
<211>  441
<212>  PRT
<213>  Homosapiens

<400>  3183

Met Ser Leu Arg Gln Arg Leu Ala Gln Leu Val Gly Arg Leu Gln Asp 
1               5                   10                  15      


Pro Gln Lys Val Ala Arg Phe Gln Arg Leu Cys Gly Val Glu Ala Pro 
            20                  25                  30          


Pro Arg Arg Ser Ala Asp Arg Arg Glu Asp Glu Lys Ala Glu Ala Pro 
        35                  40                  45              


Leu Ala Gly Asp Pro Arg Leu Arg Gly Arg Gln Pro Gly Ala Pro Gly 
    50                  55                  60                  


Gly Pro Gln Pro Pro Gly Ser Asp Arg Asn Gln Cys Pro Ala Lys Pro 
65                  70                  75                  80  


Asp Gly Gly Gly Ala Pro Asn Gly Val Arg Asn Gly Leu Ala Ala Glu 
                85                  90                  95      


Leu Gly Pro Ala Ser Pro Arg Arg Ala Gly Ala Leu Arg Arg Asn Ser 
            100                 105                 110         


Leu Thr Gly Glu Glu Gly Gln Leu Ala Arg Val Ser Asn Trp Pro Leu 
        115                 120                 125             


Tyr Cys Leu Phe Cys Phe Gly Thr Glu Leu Gly Asn Glu Leu Phe Tyr 
    130                 135                 140                 


Ile Leu Phe Phe Pro Phe Trp Ile Trp Asn Leu Asp Pro Leu Val Gly 
145                 150                 155                 160 


Arg Arg Leu Val Val Ile Trp Val Leu Val Met Tyr Leu Gly Gln Cys 
                165                 170                 175     


Thr Lys Asp Ile Ile Arg Trp Pro Arg Pro Ala Ser Pro Pro Val Val 
            180                 185                 190         


Lys Leu Glu Val Phe Tyr Asn Ser Glu Tyr Ser Met Pro Ser Thr His 
        195                 200                 205             


Ala Met Ser Gly Thr Ala Ile Pro Ile Ser Met Val Leu Leu Thr Tyr 
    210                 215                 220                 


Gly Arg Trp Gln Tyr Pro Leu Ile Tyr Gly Leu Ile Leu Ile Pro Cys 
225                 230                 235                 240 


Trp Cys Ser Leu Val Cys Leu Ser Arg Ile Tyr Met Gly Met His Ser 
                245                 250                 255     


Ile Leu Asp Ile Ile Ala Gly Phe Leu Tyr Thr Ile Leu Ile Leu Ala 
            260                 265                 270         


Val Phe Tyr Pro Phe Val Asp Leu Ile Asp Asn Phe Asn Gln Thr His 
        275                 280                 285             


Lys Tyr Ala Pro Phe Ile Ile Ile Gly Leu His Leu Ala Leu Gly Ile 
    290                 295                 300                 


Phe Ser Phe Thr Leu Asp Thr Trp Ser Thr Ser Arg Gly Asp Thr Ala 
305                 310                 315                 320 


Glu Ile Leu Gly Ser Gly Ala Gly Ile Ala Cys Gly Ser His Val Thr 
                325                 330                 335     


Tyr Asn Met Gly Leu Val Leu Asp Pro Ser Leu Asp Thr Leu Pro Leu 
            340                 345                 350         


Ala Gly Pro Pro Ile Thr Val Thr Leu Phe Gly Lys Ala Ile Leu Arg 
        355                 360                 365             


Ile Leu Ile Gly Met Val Phe Val Leu Ile Ile Arg Asp Val Met Lys 
    370                 375                 380                 


Lys Ile Thr Ile Pro Leu Ala Cys Lys Ile Phe Asn Ile Pro Cys Asp 
385                 390                 395                 400 


Asp Ile Arg Lys Ala Arg Gln His Met Glu Val Glu Leu Pro Tyr Arg 
                405                 410                 415     


Tyr Ile Thr Tyr Gly Met Val Gly Phe Ser Ile Thr Phe Phe Val Pro 
            420                 425                 430         


Tyr Ile Phe Phe Phe Ile Gly Ile Ser 
        435                 440     


<210>  3184
<211>  2193
<212>  DNA
<213>  Homosapiens

<400>  3184
cgggagccca tggagcactg tcctcagaga tgcgcaggtt aggctcactg tctaggccag     60

gcccacctta gtcactgtgg actggcaatg gaagctcttc ctggacacac ctgccctagc    120

cctcaccctg gggtggaaga gaaatgagct tggcttgcaa ctcagaccat tccacggagg    180

catcctccct tccctgggct ggtgaataaa agtttcctga ggtcaaggac ttccttttcc    240

ctgccaaaat ggtgtccaga actttgaggc cagaggtgat ccagtgattt gggagctgca    300

ggtcacacag gctgctcaga gggctgctga acaggatgtc ctcggacgac aggcacctgg    360

gctccagctg cggctccttc atcaagactg agccgtccag cccgtcctcg ggcattgatg    420

ccctcagcca ccacagcccc agtggctcgt ccgacgccag cggcggcttt ggcctggccc    480

tgggcaccca cgccaacggt ctggactcgc cacccatgtt tgcaggcgcc gggctgggag    540

gcaccccatg ccgcaagagc tacgaggact gtgccagcgg catcatggag gactcggcca    600

tcaagtgcga gtacatgctc aacgccatcc ccaagcgcct gtgcctcgtg tgcggggaca    660

ttgcctctgg ctaccactac ggcgtggcct cctgcgaggc ttgcaaggcc ttcttcaaga    720

ggactatcca agggaacatt gagtacagct gcccggccac caacgagtgc gagatcacca    780

aacggaggcg caagtcctgc caggcctgcc gcttcatgaa atgcctcaaa gtggggatgc    840

tgaaggaagg tgtgcgcctt gatcgagtgc gtggaggccg tcagaaatac aagcgacggc    900

tggactcaga gagcagccca tacctgagct tacaaatttc tccacctgct aaaaagccat    960

tgaccaagat tgtctcatac ctactggtgg ctgagccgga caagctctat gccatgcctc   1020

cccctggtat gcctgagggg gacatcaagg ccctgaccac tctctgtgac ctggcagacc   1080

gagagcttgt ggtcatcatt ggctgggcca agcacatccc aggcttctca agcctctccc   1140

tgggggacca gatgagcctg ctgcagagtg cctggatgga aatcctcatc ctgggcatcg   1200

tgtaccgctc gctgccctat gacgacaagc tggtgtacgc tgaggactac atcatggatg   1260

aggagcactc ccgcctcgcg gggctgctgg agctctaccg ggccatcctg cagctggtac   1320

gcaggtacaa gaagctcaag gtggagaagg aggagtttgt gacgctcaag gccctggccc   1380

tcgccaactc cgattccatg tacatcgagg atctagaggc tgtccagaag ctgcaggacc   1440

tgctgcacga ggcactgcag gactacgagc tgagccagcg ccatgaggag ccctggagga   1500

cgggcaagct gctgctgaca ctgccgctgc tgcggcagac ggccgccaag gccgtgcagc   1560

acttctatag cgtcaaactg cagggcaaag tgcccatgca caaactcttc ctggagatgc   1620

tggaggccaa ggcctgggcc agggctgact cccttcagga gtggaggcca ctggagcaag   1680

tgccctctcc cctccaccga gccaccaaga ggcagcatgt gcatttccta actcccttgc   1740

cccctccccc atctgtggcc tgggtgggca ctgctcaggc tggataccac ctggaggttt   1800

tccttccgca gagggcaggt tggccaagag cagcttagag gatctcccaa ggatgaaaga   1860

atgtcaagcc atgatggaaa atgccccttc caatcagctg ccttcacaag cagggatcag   1920

agcaactccc cggggatccc caatccacgc ccttctagtc caacccccct caatgagaga   1980

ggcaggcaga tctcacccag cactaggaca ccaggaggcc agggaaagca tctctggctc   2040

accatgtaac atctggcttg gagcaagtgg gtgttctgca caccaggcag ctgcacctca   2100

ctggatctag tgttgctgcg agtgacctca cttcagagcc cctctagcag agtggggcgg   2160

aagtcctgat ggttggtgtc catgaggtgg aag                                2193


<210>  3185
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  3185

Met Ser Ser Asp Asp Arg His Leu Gly Ser Ser Cys Gly Ser Phe Ile 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ser Pro Ser Ser Gly Ile Asp Ala Leu Ser His 
            20                  25                  30          


His Ser Pro Ser Gly Ser Ser Asp Ala Ser Gly Gly Phe Gly Leu Ala 
        35                  40                  45              


Leu Gly Thr His Ala Asn Gly Leu Asp Ser Pro Pro Met Phe Ala Gly 
    50                  55                  60                  


Ala Gly Leu Gly Gly Thr Pro Cys Arg Lys Ser Tyr Glu Asp Cys Ala 
65                  70                  75                  80  


Ser Gly Ile Met Glu Asp Ser Ala Ile Lys Cys Glu Tyr Met Leu Asn 
                85                  90                  95      


Ala Ile Pro Lys Arg Leu Cys Leu Val Cys Gly Asp Ile Ala Ser Gly 
            100                 105                 110         


Tyr His Tyr Gly Val Ala Ser Cys Glu Ala Cys Lys Ala Phe Phe Lys 
        115                 120                 125             


Arg Thr Ile Gln Gly Asn Ile Glu Tyr Ser Cys Pro Ala Thr Asn Glu 
    130                 135                 140                 


Cys Glu Ile Thr Lys Arg Arg Arg Lys Ser Cys Gln Ala Cys Arg Phe 
145                 150                 155                 160 


Met Lys Cys Leu Lys Val Gly Met Leu Lys Glu Gly Val Arg Leu Asp 
                165                 170                 175     


Arg Val Arg Gly Gly Arg Gln Lys Tyr Lys Arg Arg Leu Asp Ser Glu 
            180                 185                 190         


Ser Ser Pro Tyr Leu Ser Leu Gln Ile Ser Pro Pro Ala Lys Lys Pro 
        195                 200                 205             


Leu Thr Lys Ile Val Ser Tyr Leu Leu Val Ala Glu Pro Asp Lys Leu 
    210                 215                 220                 


Tyr Ala Met Pro Pro Pro Gly Met Pro Glu Gly Asp Ile Lys Ala Leu 
225                 230                 235                 240 


Thr Thr Leu Cys Asp Leu Ala Asp Arg Glu Leu Val Val Ile Ile Gly 
                245                 250                 255     


Trp Ala Lys His Ile Pro Gly Phe Ser Ser Leu Ser Leu Gly Asp Gln 
            260                 265                 270         


Met Ser Leu Leu Gln Ser Ala Trp Met Glu Ile Leu Ile Leu Gly Ile 
        275                 280                 285             


Val Tyr Arg Ser Leu Pro Tyr Asp Asp Lys Leu Val Tyr Ala Glu Asp 
    290                 295                 300                 


Tyr Ile Met Asp Glu Glu His Ser Arg Leu Ala Gly Leu Leu Glu Leu 
305                 310                 315                 320 


Tyr Arg Ala Ile Leu Gln Leu Val Arg Arg Tyr Lys Lys Leu Lys Val 
                325                 330                 335     


Glu Lys Glu Glu Phe Val Thr Leu Lys Ala Leu Ala Leu Ala Asn Ser 
            340                 345                 350         


Asp Ser Met Tyr Ile Glu Asp Leu Glu Ala Val Gln Lys Leu Gln Asp 
        355                 360                 365             


Leu Leu His Glu Ala Leu Gln Asp Tyr Glu Leu Ser Gln Arg His Glu 
    370                 375                 380                 


Glu Pro Trp Arg Thr Gly Lys Leu Leu Leu Thr Leu Pro Leu Leu Arg 
385                 390                 395                 400 


Gln Thr Ala Ala Lys Ala Val Gln His Phe Tyr Ser Val Lys Leu Gln 
                405                 410                 415     


Gly Lys Val Pro Met His Lys Leu Phe Leu Glu Met Leu Glu Ala Lys 
            420                 425                 430         


Ala Trp Ala Arg Ala Asp Ser Leu Gln Glu Trp Arg Pro Leu Glu Gln 
        435                 440                 445             


Val Pro Ser Pro Leu His Arg Ala Thr Lys Arg Gln His Val His Phe 
    450                 455                 460                 


Leu Thr Pro Leu Pro Pro Pro Pro Ser Val Ala Trp Val Gly Thr Ala 
465                 470                 475                 480 


Gln Ala Gly Tyr His Leu Glu Val Phe Leu Pro Gln Arg Ala Gly Trp 
                485                 490                 495     


Pro Arg Ala Ala 
            500 


<210>  3186
<211>  1751
<212>  DNA
<213>  Homosapiens

<400>  3186
cgcagccccg gttcccgccc gtgcctctcc ctccacacct ccctgcaggc tgagggagcc     60

ggctccggtc tcggccatcc caggaagggg ctcccacagt gcagcggcgg gctgaagggc    120

tcctcaagcg tggccagagt gggcgccaag gccgaggagg cgccaagagg gagcgagggc    180

tgtgaggact gacagcacgc tgtcacctcg tctctactta ggtgaatgat gcctttggcc    240

tgcttatgtc ttccatagcc acaatgaata cagttgcaga aactctcact ctttatggaa    300

aatagaaggg aatatgtaca agaaacaatt actgtatgca gataaggcag atggtgtctt    360

tgacatttca tcaaggcagc agcatctgaa agtttttcaa gaaactgcca aactgttctc    420

cagagtattt gtaccatttt acgtttccac cagcaatata caagtggatc tcactctgtc    480

acccaagctg gagtgcactg gcatgatatt ggctcactgc aacctctgcc ttctgggttc    540

aggtgattct cctacctcag cctccccagt agctggaact acaggcatgc accaattttt    600

gtatttttag tagagacggg gtttttccat gatgcccagg ctgttggctt ttactttgcc    660

tttccataat catcttgtat gtgtgagata catacatata tatgtgtata tatgtataca    720

taattgtata tgtctatata tataacctta ttatatataa ttttataata taatcttcat    780

ctaattttga tggaaattac attaaacttg tgtaacaatt caggaagaac tgatatattt    840

acacctcttg agaccaaatc tggaacatgg tgtatctttc catttattta agccttcttt    900

gatttcctca acatttcttc ttcaataaaa acattgtagt ttttgttata taaattctgt    960

atctgttttg ttacatttga acctaaacat ttaatttttt gagtaattct gaaatgatat   1020

tgcatttcta attgtttctc atatattctt tgctaatatg taaaaaaaca atttttttat   1080

gtttatcttg tatcctgtga ccttattgaa gtcacttttt agttctgaga gtccctttgt   1140

agatttcttg agattttcta cagagacaat cataccattt gcaaatagaa acagttctat   1200

tcctaccttt ctaatacata agcattcatc tccttcatct atcatacttg ccaaaacttc   1260

cagcagatgt ctttactttg tttcttctgt ttacccaaga cagtctttct gtctttttct   1320

ttctttcttt ctttcttttt tagcttttct tgttattgtt tctatatgct ctttatcaag   1380

ttaagaaagt cctcctctgt ctctatgttt cttggaatat atataatgaa tggatgttaa   1440

attttgtcaa atactttttc ttgactgata ttatcatgtg atttttcttt aacttgttaa   1500

tatgttagat tacattgatc tttgaatatt gtaccagcct tgcattcttg taataaactt   1560

tatttggtta cagtgtataa tcaaatatag tgagttattt gaattgaatt tgaattgtta   1620

tagttgaatt gtttttgtta atatttcatt aaggattttg tttctatgta taatagggat   1680

atttttctgt agattttgtt tcgttttggt ttttaagtat cagagtaatg ccagcttctt   1740

aaataaattg t                                                        1751


<210>  3187
<211>  98
<212>  PRT
<213>  Homosapiens

<400>  3187

Met Tyr Lys Lys Gln Leu Leu Tyr Ala Asp Lys Ala Asp Gly Val Phe 
1               5                   10                  15      


Asp Ile Ser Ser Arg Gln Gln His Leu Lys Val Phe Gln Glu Thr Ala 
            20                  25                  30          


Lys Leu Phe Ser Arg Val Phe Val Pro Phe Tyr Val Ser Thr Ser Asn 
        35                  40                  45              


Ile Gln Val Asp Leu Thr Leu Ser Pro Lys Leu Glu Cys Thr Gly Met 
    50                  55                  60                  


Ile Leu Ala His Cys Asn Leu Cys Leu Leu Gly Ser Gly Asp Ser Pro 
65                  70                  75                  80  


Thr Ser Ala Ser Pro Val Ala Gly Thr Thr Gly Met His Gln Phe Leu 
                85                  90                  95      


Tyr Phe 
        


<210>  3188
<211>  4485
<212>  DNA
<213>  Homosapiens

<400>  3188
ctcaaagttc gcaggaggcg agagatgctg ccgcagcaag tcggcttcgt gtgcgcggtg     60

ctggccctgg tgtgctgtgc gtccggcctc ttcggcagct tggggcacaa aacagcttct    120

gctagcaaac gtgtcctgcc agacacatgg agaaatagaa agttgatggc cccagtgaat    180

gggacacaga cagccaagaa ctgcacagat cctgcgattc acgagttccc cacagatctg    240

ttctccaata aggagcgaca gcacggagcc gtcctgctgc acatccttgg tgctctgtat    300

atgttctatg ccttggccat agtgtgcgat gacttctttg ttccgtctct agagaagatc    360

tgtgagagac tccatctgag cgaagatgtg gctggagcca ccttcatggc tgcaggaagc    420

tcaacgccag agctgtttgc gtctgttatt ggggtgttca tcacccatgg ggacgtcggg    480

gtgggcacca tcgtgggctc tgctgtgttc aacatcctgt gcataattgg agtgtgcgga    540

ctgtttgctg gccaggtggt ccgtctgacg tggtgggccg tgtgccgaga ctccgtgtac    600

tacaccatct ctgtcatcgt gctcatcgtg ttcatatatg atgaacaaat tgtgtggtgg    660

gaaggcctgg tgctcatcat cttgtatgtg ttttatattc tgatcatgaa gtacaatgtg    720

aagatgcaag cctttttcac agtcaaacaa aagagcattg caaacggtaa cccggtcaac    780

agtgagctgg aggctggtaa tgatttctat gacggtagct atgatgaccc ttccgtgcca    840

ttgctggggc aagtgaagga gaagccacag tatggcaaga accccgtggt gatggtggac    900

gagattatga gctccagccc tcccaagttc accttccctg aagcaggctt acgaatcatg    960

atcaccaata agtttggacc caggacccga ctacggatgg ccagcaggat catcattaat   1020

gagcggcaga gactgatcaa ctcggccaat ggtgtgagca gtaagccgct tcaaaacggg   1080

aggcacgaga acattgagaa cgggaatgtt cctgtggaaa accccgaaga ccctcagcag   1140

aatcaggagc agcagccgcc gccacagcca ccaccgccag agccagagcc ggtggaggct   1200

gacttcctgt cccccttctc cgtgccggag gccagagggg acaaggtcaa gtgggtgttc   1260

acctggcccc tcatcttcct cctgtgcgtc accattccca actgcagcaa gccccgctgg   1320

gagaagttct tcatggtcac cttcatcacc gccacgctgt ggatcgctgt gttctcctac   1380

atcatggtgt ggctggtgac tattatcgga tacacacttg ggatcccgga tgtcatcatg   1440

ggcattactt tcctggcagc agggacaagt gttccagact gcatggccag cctaattgtg   1500

gcgagacaag gccttgggga catggcagtc tccaacacca taggaagcaa cgtgtttgac   1560

atcctggtag gacttggtgt accgtggggc ctgcagacca tggttgttaa ttatggatca   1620

acagtgaaga tcaacagccg ggggctggtc tattccgtgg tcctgttgct gggctctgtc   1680

gctctcaccg tcctcggcat ccacctaaac aagtggcgac tggaccggaa gctgggtgtc   1740

tacgtgctgg ttctctacgc catcttcttg tgcttctcca taatgataga gtttaacgtc   1800

tttaccttcg tcaacttgcc gatgtgccgg gaagacgatt agcgctgagt cgcggcccct   1860

gggagctgat ctggacaccc tgtgacactg gcgttctcct ctcccctcct tcccccacca   1920

caggtctctc ctgcataggc agccactgtc cgttctttca cacactggaa ggaagagcca   1980

tcgtggtctt tgtctggcca caggccaggc tgctgggcat cctcctcctc cttggagttc   2040

cgcccctgca aggctggatt tgggggccat tatctgagca gcttcaaaga cccctgagct   2100

gccaaccacg gagatgtgcc aagcatctca tctctcctgc acactttagt cagaaggact   2160

tctgcatgca gtttgtcttt ctgttctgca ggcagcttca gaattgaggt catttgtgag   2220

cacaagatct catagggcag gtgcaaaata ggaatgttgt tctcaagtgt cacctccagc   2280

ccagaggtgg ttccttaggc agcatgtgct cctgggagcc tctgactttt gctggaagca   2340

gccacagttt ggaaggggca agacctcaac ctgttggggt ttagggccca tgatggcaga   2400

cattctaccc cttttcctgg aaaaactgga agaatgaaaa taattttttt ctgtggaaga   2460

gagaaaatga gtgaatattc ttctcacttt tattgatgca ttcagagaat aagcaatgaa   2520

atattaaaaa atgaaacatc atataggtca tcatacttga aaattatcat tccatatgaa   2580

aggatcatga tacacaccaa aaaagtaatg atcgtaaaga cacaaatcct ctgtatgcca   2640

tcttgcattg gcactgaggt gtttggtttg gaatagggaa aaaggtaaga gactaacgtg   2700

gaaaggtgct aactcagaga ctggagatta tagtttacag ctgtactttc cagatcttct   2760

atgtgacaca atgcactgtc cttgtgggtt tgtcatttat tggttaatgc tctagtttca   2820

aaaccaccct gttgaaagtt ccagttattt atatgcccaa caaatttcat agcctgctga   2880

actgaactga gtgtgtcaga agtgctggtt aatgacgaga agagattgcc tgaaaaacaa   2940

caaactgctt tctggttagc tgaaggcaag tgtgaaaatc agaatttaga atatttagag   3000

ctaagcttct ggaaccacgt agtttctaca cgtggcaggc caagaatggg aggctgactc   3060

aaaactagat agaaaaatat aaaataatct tcgaccactt gatagctctc aaatatatat   3120

ttaaaagatt tatgaataca aaccatttat ggtttatgat ttctaaaaag aaagcacaat   3180

taattttata gagaggtttt ttattttttt aatatttcta ttgcaaaagt ctatccgatt   3240

tgatgcactt tgaatattga gatattttgc acggatgaat gtatgggaac tacccatgat   3300

gatgtaagag gaaagaacat ttttttgtga ttcaccagac atcactttaa acttggtgat   3360

gagtttaaat ccagtagcta atcccttcct gagactcaaa gatcgtgacg ctggttggaa   3420

tttctgactg tgccctttag ggcctcctga gtttcaaaag gaggaagtgt tcgtgcttgt   3480

gtccctgaag ttccctgttg catgagcctg cgacaggacc tcacccccac caccaggctt   3540

ctatttggga ttcacatcag tattagtatc gtagctacac caagttcagg cttctctttt   3600

tgttttttta cctagaaatt gggctcagtg gtcttcaact tgaggacgag ggtgattttc   3660

ctaagaaatc agcaaagagg gaaggcaggg cccctgtaga ttcaccagta taaacttcag   3720

ctgcagggat tccagagccc tcgggaccac tctgtcacct taatagccaa gttctcctgg   3780

ttcctccgat cttacaggct catccaggtt ccaaagtgct tctgtctctg ttttgattct   3840

ccaaactgct ctgtgatgta tgtagggatt attctcccca cttaacagaa agtagtgtct   3900

tggagaggtc aagggtctct agttcaatgg ccagtcatag cagaagggag gccaagcacc   3960

agtccatcac ccctcccagg ccagcctctg taagttggcc acacttgggg agtgagtgtg   4020

ggtatgactt taccctcctg gttggttctt actgtttgag tcaaaacctc atcaatatat   4080

cattgactcc tgggttcctc aggtcatttc ctaatatctg tccctatcca atgcctctat   4140

tttatcttga aaaaaggacc aaaaattatt tttagctatg gcaaggcaca ggccacatgg   4200

cccctgatgg cgtccctgct ggttttcaat tctctgaagc cttgtgtagc tttcagagca   4260

cacgtatcct aattaccctc ctcttcctca gcagaaccca tttgagattc taaatgaata   4320

ctcttagtct ctaaagttgc agttagaaac taaaataatg ttttttaata tgtaatatgc   4380

tcctcttggc taattttctt ttgactttaa tgtgccaatg taacttcctt taaaggatct   4440

atgcatttat taaatctgga aaactaaaaa aaaaaaaaaa aaaaa                   4485


<210>  3189
<211>  605
<212>  PRT
<213>  Homosapiens

<400>  3189

Met Leu Pro Gln Gln Val Gly Phe Val Cys Ala Val Leu Ala Leu Val 
1               5                   10                  15      


Cys Cys Ala Ser Gly Leu Phe Gly Ser Leu Gly His Lys Thr Ala Ser 
            20                  25                  30          


Ala Ser Lys Arg Val Leu Pro Asp Thr Trp Arg Asn Arg Lys Leu Met 
        35                  40                  45              


Ala Pro Val Asn Gly Thr Gln Thr Ala Lys Asn Cys Thr Asp Pro Ala 
    50                  55                  60                  


Ile His Glu Phe Pro Thr Asp Leu Phe Ser Asn Lys Glu Arg Gln His 
65                  70                  75                  80  


Gly Ala Val Leu Leu His Ile Leu Gly Ala Leu Tyr Met Phe Tyr Ala 
                85                  90                  95      


Leu Ala Ile Val Cys Asp Asp Phe Phe Val Pro Ser Leu Glu Lys Ile 
            100                 105                 110         


Cys Glu Arg Leu His Leu Ser Glu Asp Val Ala Gly Ala Thr Phe Met 
        115                 120                 125             


Ala Ala Gly Ser Ser Thr Pro Glu Leu Phe Ala Ser Val Ile Gly Val 
    130                 135                 140                 


Phe Ile Thr His Gly Asp Val Gly Val Gly Thr Ile Val Gly Ser Ala 
145                 150                 155                 160 


Val Phe Asn Ile Leu Cys Ile Ile Gly Val Cys Gly Leu Phe Ala Gly 
                165                 170                 175     


Gln Val Val Arg Leu Thr Trp Trp Ala Val Cys Arg Asp Ser Val Tyr 
            180                 185                 190         


Tyr Thr Ile Ser Val Ile Val Leu Ile Val Phe Ile Tyr Asp Glu Gln 
        195                 200                 205             


Ile Val Trp Trp Glu Gly Leu Val Leu Ile Ile Leu Tyr Val Phe Tyr 
    210                 215                 220                 


Ile Leu Ile Met Lys Tyr Asn Val Lys Met Gln Ala Phe Phe Thr Val 
225                 230                 235                 240 


Lys Gln Lys Ser Ile Ala Asn Gly Asn Pro Val Asn Ser Glu Leu Glu 
                245                 250                 255     


Ala Gly Asn Asp Phe Tyr Asp Gly Ser Tyr Asp Asp Pro Ser Val Pro 
            260                 265                 270         


Leu Leu Gly Gln Val Lys Glu Lys Pro Gln Tyr Gly Lys Asn Pro Val 
        275                 280                 285             


Val Met Val Asp Glu Ile Met Ser Ser Ser Pro Pro Lys Phe Thr Phe 
    290                 295                 300                 


Pro Glu Ala Gly Leu Arg Ile Met Ile Thr Asn Lys Phe Gly Pro Arg 
305                 310                 315                 320 


Thr Arg Leu Arg Met Ala Ser Arg Ile Ile Ile Asn Glu Arg Gln Arg 
                325                 330                 335     


Leu Ile Asn Ser Ala Asn Gly Val Ser Ser Lys Pro Leu Gln Asn Gly 
            340                 345                 350         


Arg His Glu Asn Ile Glu Asn Gly Asn Val Pro Val Glu Asn Pro Glu 
        355                 360                 365             


Asp Pro Gln Gln Asn Gln Glu Gln Gln Pro Pro Pro Gln Pro Pro Pro 
    370                 375                 380                 


Pro Glu Pro Glu Pro Val Glu Ala Asp Phe Leu Ser Pro Phe Ser Val 
385                 390                 395                 400 


Pro Glu Ala Arg Gly Asp Lys Val Lys Trp Val Phe Thr Trp Pro Leu 
                405                 410                 415     


Ile Phe Leu Leu Cys Val Thr Ile Pro Asn Cys Ser Lys Pro Arg Trp 
            420                 425                 430         


Glu Lys Phe Phe Met Val Thr Phe Ile Thr Ala Thr Leu Trp Ile Ala 
        435                 440                 445             


Val Phe Ser Tyr Ile Met Val Trp Leu Val Thr Ile Ile Gly Tyr Thr 
    450                 455                 460                 


Leu Gly Ile Pro Asp Val Ile Met Gly Ile Thr Phe Leu Ala Ala Gly 
465                 470                 475                 480 


Thr Ser Val Pro Asp Cys Met Ala Ser Leu Ile Val Ala Arg Gln Gly 
                485                 490                 495     


Leu Gly Asp Met Ala Val Ser Asn Thr Ile Gly Ser Asn Val Phe Asp 
            500                 505                 510         


Ile Leu Val Gly Leu Gly Val Pro Trp Gly Leu Gln Thr Met Val Val 
        515                 520                 525             


Asn Tyr Gly Ser Thr Val Lys Ile Asn Ser Arg Gly Leu Val Tyr Ser 
    530                 535                 540                 


Val Val Leu Leu Leu Gly Ser Val Ala Leu Thr Val Leu Gly Ile His 
545                 550                 555                 560 


Leu Asn Lys Trp Arg Leu Asp Arg Lys Leu Gly Val Tyr Val Leu Val 
                565                 570                 575     


Leu Tyr Ala Ile Phe Leu Cys Phe Ser Ile Met Ile Glu Phe Asn Val 
            580                 585                 590         


Phe Thr Phe Val Asn Leu Pro Met Cys Arg Glu Asp Asp 
        595                 600                 605 


<210>  3190
<211>  4428
<212>  DNA
<213>  Homosapiens

<400>  3190
ctcaaagttc gcaggaggcg agagatgctg ccgcagcaag tcggcttcgt gtgcgcggtg     60

ctggccctgg tgtgctgtgc gtccggcctc ttcggcagct tggggcacaa aacagcttct    120

gctagcaaac gtgtcctgcc agacacatgg agaaatagaa agttgatggc cccagtgaat    180

gggacacaga cagccaagaa ctgcacagat cctgcgattc acgagttccc cacagatctg    240

ttctccaata aggagcgaca gcacggagcc gtcctgctgc acatccttgg tgctctgtat    300

atgttctatg ccttggccat agtgtgcgat gacttctttg ttccgtctct agagaagatc    360

tgtgagagac tccatctgag cgaagatgtg gctggagcca ccttcatggc tgcaggaagc    420

tcaacgccag agctgtttgc gtctgttatt ggggtgttca tcacccatgg ggacgtcggg    480

gtgggcacca tcgtgggctc tgctgtgttc aacatcctgt gcataattgg agtgtgcgga    540

ctgtttgctg gccaggtggt ccgtctgacg tggtgggccg tgtgccgaga ctccgtgtac    600

tacaccatct ctgtcatcgt gctcatcgtg ttcatatatg atgaacaaat tgtgtggtgg    660

gaaggcctgg tgctcatcat cttgtatgtg ttttatattc tgatcatgaa gtacaatgtg    720

aagatgcaag cctttttcac agtcaaacaa aagagcattg caaacggtaa cccggtcaac    780

agtgagctgg aggctgtgaa ggagaagcca cagtatggca agaaccccgt ggtgatggtg    840

gacgagatta tgagctccag ccctcccaag ttcaccttcc ctgaagcagg cttacgaatc    900

atgatcacca ataagtttgg acccaggacc cgactacgga tggccagcag gatcatcatt    960

aatgagcggc agagactgat caactcggcc aatggtgtga gcagtaagcc gcttcaaaac   1020

gggaggcacg agaacattga gaacgggaat gttcctgtgg aaaaccccga agaccctcag   1080

cagaatcagg agcagcagcc gccgccacag ccaccaccgc cagagccaga gccggtggag   1140

gctgacttcc tgtccccctt ctccgtgccg gaggccagag gggacaaggt caagtgggtg   1200

ttcacctggc ccctcatctt cctcctgtgc gtcaccattc ccaactgcag caagccccgc   1260

tgggagaagt tcttcatggt caccttcatc accgccacgc tgtggatcgc tgtgttctcc   1320

tacatcatgg tgtggctggt gactattatc ggatacacac ttgggatccc ggatgtcatc   1380

atgggcatta ctttcctggc agcagggaca agtgttccag actgcatggc cagcctaatt   1440

gtggcgagac aaggccttgg ggacatggca gtctccaaca ccataggaag caacgtgttt   1500

gacatcctgg taggacttgg tgtaccgtgg ggcctgcaga ccatggttgt taattatgga   1560

tcaacagtga agatcaacag ccgggggctg gtctattccg tggtcctgtt gctgggctct   1620

gtcgctctca ccgtcctcgg catccaccta aacaagtggc gactggaccg gaagctgggt   1680

gtctacgtgc tggttctcta cgccatcttc ttgtgcttct ccataatgat agagtttaac   1740

gtctttacct tcgtcaactt gccgatgtgc cgggaagacg attagcgctg agtcgcggcc   1800

cctgggagct gatctggaca ccctgtgaca ctggcgttct cctctcccct ccttccccca   1860

ccacaggtct ctcctgcata ggcagccact gtccgttctt tcacacactg gaaggaagag   1920

ccatcgtggt ctttgtctgg ccacaggcca ggctgctggg catcctcctc ctccttggag   1980

ttccgcccct gcaaggctgg atttgggggc cattatctga gcagcttcaa agacccctga   2040

gctgccaacc acggagatgt gccaagcatc tcatctctcc tgcacacttt agtcagaagg   2100

acttctgcat gcagtttgtc tttctgttct gcaggcagct tcagaattga ggtcatttgt   2160

gagcacaaga tctcataggg caggtgcaaa ataggaatgt tgttctcaag tgtcacctcc   2220

agcccagagg tggttcctta ggcagcatgt gctcctggga gcctctgact tttgctggaa   2280

gcagccacag tttggaaggg gcaagacctc aacctgttgg ggtttagggc ccatgatggc   2340

agacattcta ccccttttcc tggaaaaact ggaagaatga aaataatttt tttctgtgga   2400

agagagaaaa tgagtgaata ttcttctcac ttttattgat gcattcagag aataagcaat   2460

gaaatattaa aaaatgaaac atcatatagg tcatcatact tgaaaattat cattccatat   2520

gaaaggatca tgatacacac caaaaaagta atgatcgtaa agacacaaat cctctgtatg   2580

ccatcttgca ttggcactga ggtgtttggt ttggaatagg gaaaaaggta agagactaac   2640

gtggaaaggt gctaactcag agactggaga ttatagttta cagctgtact ttccagatct   2700

tctatgtgac acaatgcact gtccttgtgg gtttgtcatt tattggttaa tgctctagtt   2760

tcaaaaccac cctgttgaaa gttccagtta tttatatgcc caacaaattt catagcctgc   2820

tgaactgaac tgagtgtgtc agaagtgctg gttaatgacg agaagagatt gcctgaaaaa   2880

caacaaactg ctttctggtt agctgaaggc aagtgtgaaa atcagaattt agaatattta   2940

gagctaagct tctggaacca cgtagtttct acacgtggca ggccaagaat gggaggctga   3000

ctcaaaacta gatagaaaaa tataaaataa tcttcgacca cttgatagct ctcaaatata   3060

tatttaaaag atttatgaat acaaaccatt tatggtttat gatttctaaa aagaaagcac   3120

aattaatttt atagagaggt tttttatttt tttaatattt ctattgcaaa agtctatccg   3180

atttgatgca ctttgaatat tgagatattt tgcacggatg aatgtatggg aactacccat   3240

gatgatgtaa gaggaaagaa catttttttg tgattcacca gacatcactt taaacttggt   3300

gatgagttta aatccagtag ctaatccctt cctgagactc aaagatcgtg acgctggttg   3360

gaatttctga ctgtgccctt tagggcctcc tgagtttcaa aaggaggaag tgttcgtgct   3420

tgtgtccctg aagttccctg ttgcatgagc ctgcgacagg acctcacccc caccaccagg   3480

cttctatttg ggattcacat cagtattagt atcgtagcta caccaagttc aggcttctct   3540

ttttgttttt ttacctagaa attgggctca gtggtcttca acttgaggac gagggtgatt   3600

ttcctaagaa atcagcaaag agggaaggca gggcccctgt agattcacca gtataaactt   3660

cagctgcagg gattccagag ccctcgggac cactctgtca ccttaatagc caagttctcc   3720

tggttcctcc gatcttacag gctcatccag gttccaaagt gcttctgtct ctgttttgat   3780

tctccaaact gctctgtgat gtatgtaggg attattctcc ccacttaaca gaaagtagtg   3840

tcttggagag gtcaagggtc tctagttcaa tggccagtca tagcagaagg gaggccaagc   3900

accagtccat cacccctccc aggccagcct ctgtaagttg gccacacttg gggagtgagt   3960

gtgggtatga ctttaccctc ctggttggtt cttactgttt gagtcaaaac ctcatcaata   4020

tatcattgac tcctgggttc ctcaggtcat ttcctaatat ctgtccctat ccaatgcctc   4080

tattttatct tgaaaaaagg accaaaaatt atttttagct atggcaaggc acaggccaca   4140

tggcccctga tggcgtccct gctggttttc aattctctga agccttgtgt agctttcaga   4200

gcacacgtat cctaattacc ctcctcttcc tcagcagaac ccatttgaga ttctaaatga   4260

atactcttag tctctaaagt tgcagttaga aactaaaata atgtttttta atatgtaata   4320

tgctcctctt ggctaatttt cttttgactt taatgtgcca atgtaacttc ctttaaagga   4380

tctatgcatt tattaaatct ggaaaactaa aaaaaaaaaa aaaaaaaa                4428


<210>  3191
<211>  586
<212>  PRT
<213>  Homosapiens

<400>  3191

Met Leu Pro Gln Gln Val Gly Phe Val Cys Ala Val Leu Ala Leu Val 
1               5                   10                  15      


Cys Cys Ala Ser Gly Leu Phe Gly Ser Leu Gly His Lys Thr Ala Ser 
            20                  25                  30          


Ala Ser Lys Arg Val Leu Pro Asp Thr Trp Arg Asn Arg Lys Leu Met 
        35                  40                  45              


Ala Pro Val Asn Gly Thr Gln Thr Ala Lys Asn Cys Thr Asp Pro Ala 
    50                  55                  60                  


Ile His Glu Phe Pro Thr Asp Leu Phe Ser Asn Lys Glu Arg Gln His 
65                  70                  75                  80  


Gly Ala Val Leu Leu His Ile Leu Gly Ala Leu Tyr Met Phe Tyr Ala 
                85                  90                  95      


Leu Ala Ile Val Cys Asp Asp Phe Phe Val Pro Ser Leu Glu Lys Ile 
            100                 105                 110         


Cys Glu Arg Leu His Leu Ser Glu Asp Val Ala Gly Ala Thr Phe Met 
        115                 120                 125             


Ala Ala Gly Ser Ser Thr Pro Glu Leu Phe Ala Ser Val Ile Gly Val 
    130                 135                 140                 


Phe Ile Thr His Gly Asp Val Gly Val Gly Thr Ile Val Gly Ser Ala 
145                 150                 155                 160 


Val Phe Asn Ile Leu Cys Ile Ile Gly Val Cys Gly Leu Phe Ala Gly 
                165                 170                 175     


Gln Val Val Arg Leu Thr Trp Trp Ala Val Cys Arg Asp Ser Val Tyr 
            180                 185                 190         


Tyr Thr Ile Ser Val Ile Val Leu Ile Val Phe Ile Tyr Asp Glu Gln 
        195                 200                 205             


Ile Val Trp Trp Glu Gly Leu Val Leu Ile Ile Leu Tyr Val Phe Tyr 
    210                 215                 220                 


Ile Leu Ile Met Lys Tyr Asn Val Lys Met Gln Ala Phe Phe Thr Val 
225                 230                 235                 240 


Lys Gln Lys Ser Ile Ala Asn Gly Asn Pro Val Asn Ser Glu Leu Glu 
                245                 250                 255     


Ala Val Lys Glu Lys Pro Gln Tyr Gly Lys Asn Pro Val Val Met Val 
            260                 265                 270         


Asp Glu Ile Met Ser Ser Ser Pro Pro Lys Phe Thr Phe Pro Glu Ala 
        275                 280                 285             


Gly Leu Arg Ile Met Ile Thr Asn Lys Phe Gly Pro Arg Thr Arg Leu 
    290                 295                 300                 


Arg Met Ala Ser Arg Ile Ile Ile Asn Glu Arg Gln Arg Leu Ile Asn 
305                 310                 315                 320 


Ser Ala Asn Gly Val Ser Ser Lys Pro Leu Gln Asn Gly Arg His Glu 
                325                 330                 335     


Asn Ile Glu Asn Gly Asn Val Pro Val Glu Asn Pro Glu Asp Pro Gln 
            340                 345                 350         


Gln Asn Gln Glu Gln Gln Pro Pro Pro Gln Pro Pro Pro Pro Glu Pro 
        355                 360                 365             


Glu Pro Val Glu Ala Asp Phe Leu Ser Pro Phe Ser Val Pro Glu Ala 
    370                 375                 380                 


Arg Gly Asp Lys Val Lys Trp Val Phe Thr Trp Pro Leu Ile Phe Leu 
385                 390                 395                 400 


Leu Cys Val Thr Ile Pro Asn Cys Ser Lys Pro Arg Trp Glu Lys Phe 
                405                 410                 415     


Phe Met Val Thr Phe Ile Thr Ala Thr Leu Trp Ile Ala Val Phe Ser 
            420                 425                 430         


Tyr Ile Met Val Trp Leu Val Thr Ile Ile Gly Tyr Thr Leu Gly Ile 
        435                 440                 445             


Pro Asp Val Ile Met Gly Ile Thr Phe Leu Ala Ala Gly Thr Ser Val 
    450                 455                 460                 


Pro Asp Cys Met Ala Ser Leu Ile Val Ala Arg Gln Gly Leu Gly Asp 
465                 470                 475                 480 


Met Ala Val Ser Asn Thr Ile Gly Ser Asn Val Phe Asp Ile Leu Val 
                485                 490                 495     


Gly Leu Gly Val Pro Trp Gly Leu Gln Thr Met Val Val Asn Tyr Gly 
            500                 505                 510         


Ser Thr Val Lys Ile Asn Ser Arg Gly Leu Val Tyr Ser Val Val Leu 
        515                 520                 525             


Leu Leu Gly Ser Val Ala Leu Thr Val Leu Gly Ile His Leu Asn Lys 
    530                 535                 540                 


Trp Arg Leu Asp Arg Lys Leu Gly Val Tyr Val Leu Val Leu Tyr Ala 
545                 550                 555                 560 


Ile Phe Leu Cys Phe Ser Ile Met Ile Glu Phe Asn Val Phe Thr Phe 
                565                 570                 575     


Val Asn Leu Pro Met Cys Arg Glu Asp Asp 
            580                 585     


<210>  3192
<211>  4437
<212>  DNA
<213>  Homosapiens

<400>  3192
gggcccgcag atctctctgg ttcccctctc tgccccgtct ccagcttttt tgcagggcac     60

aaaacagctt ctgctagcaa acgtgtcctg ccagacacat ggagaaatag aaagttgatg    120

gccccagtga atgggacaca gacagccaag aactgcacag atcctgcgat tcacgagttc    180

cccacagatc tgttctccaa taaggagcga cagcacggag ccgtcctgct gcacatcctt    240

ggtgctctgt atatgttcta tgccttggcc atagtgtgcg atgacttctt tgttccgtct    300

ctagagaaga tctgtgagag actccatctg agcgaagatg tggctggagc caccttcatg    360

gctgcaggaa gctcaacgcc agagctgttt gcgtctgtta ttggggtgtt catcacccat    420

ggggacgtcg gggtgggcac catcgtgggc tctgctgtgt tcaacatcct gtgcataatt    480

ggagtgtgcg gactgtttgc tggccaggtg gtccgtctga cgtggtgggc cgtgtgccga    540

gactccgtgt actacaccat ctctgtcatc gtgctcatcg tgttcatata tgatgaacaa    600

attgtgtggt gggaaggcct ggtgctcatc atcttgtatg tgttttatat tctgatcatg    660

aagtacaatg tgaagatgca agcctttttc acagtcaaac aaaagagcat tgcaaacggt    720

aacccggtca acagtgagct ggaggctggt aatgatttct atgacggtag ctatgatgac    780

ccttccgtgc cattgctggg gcaagtgaag gagaagccac agtatggcaa gaaccccgtg    840

gtgatggtgg acgagattat gagctccagc cctcccaagt tcaccttccc tgaagcaggc    900

ttacgaatca tgatcaccaa taagtttgga cccaggaccc gactacggat ggccagcagg    960

atcatcatta atgagcggca gagactgatc aactcggcca atggtgtgag cagtaagccg   1020

cttcaaaacg ggaggcacga gaacattgag aacgggaatg ttcctgtgga aaaccccgaa   1080

gaccctcagc agaatcagga gcagcagccg ccgccacagc caccaccgcc agagccagag   1140

ccggtggagg ctgacttcct gtcccccttc tccgtgccgg aggccagagg ggacaaggtc   1200

aagtgggtgt tcacctggcc cctcatcttc ctcctgtgcg tcaccattcc caactgcagc   1260

aagccccgct gggagaagtt cttcatggtc accttcatca ccgccacgct gtggatcgct   1320

gtgttctcct acatcatggt gtggctggtg actattatcg gatacacact tgggatcccg   1380

gatgtcatca tgggcattac tttcctggca gcagggacaa gtgttccaga ctgcatggcc   1440

agcctaattg tggcgagaca aggccttggg gacatggcag tctccaacac cataggaagc   1500

aacgtgtttg acatcctggt aggacttggt gtaccgtggg gcctgcagac catggttgtt   1560

aattatggat caacagtgaa gatcaacagc cgggggctgg tctattccgt ggtcctgttg   1620

ctgggctctg tcgctctcac cgtcctcggc atccacctaa acaagtggcg actggaccgg   1680

aagctgggtg tctacgtgct ggttctctac gccatcttct tgtgcttctc cataatgata   1740

gagtttaacg tctttacctt cgtcaacttg ccgatgtgcc gggaagacga ttagcgctga   1800

gtcgcggccc ctgggagctg atctggacac cctgtgacac tggcgttctc ctctcccctc   1860

cttcccccac cacaggtctc tcctgcatag gcagccactg tccgttcttt cacacactgg   1920

aaggaagagc catcgtggtc tttgtctggc cacaggccag gctgctgggc atcctcctcc   1980

tccttggagt tccgcccctg caaggctgga tttgggggcc attatctgag cagcttcaaa   2040

gacccctgag ctgccaacca cggagatgtg ccaagcatct catctctcct gcacacttta   2100

gtcagaagga cttctgcatg cagtttgtct ttctgttctg caggcagctt cagaattgag   2160

gtcatttgtg agcacaagat ctcatagggc aggtgcaaaa taggaatgtt gttctcaagt   2220

gtcacctcca gcccagaggt ggttccttag gcagcatgtg ctcctgggag cctctgactt   2280

ttgctggaag cagccacagt ttggaagggg caagacctca acctgttggg gtttagggcc   2340

catgatggca gacattctac cccttttcct ggaaaaactg gaagaatgaa aataattttt   2400

ttctgtggaa gagagaaaat gagtgaatat tcttctcact tttattgatg cattcagaga   2460

ataagcaatg aaatattaaa aaatgaaaca tcatataggt catcatactt gaaaattatc   2520

attccatatg aaaggatcat gatacacacc aaaaaagtaa tgatcgtaaa gacacaaatc   2580

ctctgtatgc catcttgcat tggcactgag gtgtttggtt tggaataggg aaaaaggtaa   2640

gagactaacg tggaaaggtg ctaactcaga gactggagat tatagtttac agctgtactt   2700

tccagatctt ctatgtgaca caatgcactg tccttgtggg tttgtcattt attggttaat   2760

gctctagttt caaaaccacc ctgttgaaag ttccagttat ttatatgccc aacaaatttc   2820

atagcctgct gaactgaact gagtgtgtca gaagtgctgg ttaatgacga gaagagattg   2880

cctgaaaaac aacaaactgc tttctggtta gctgaaggca agtgtgaaaa tcagaattta   2940

gaatatttag agctaagctt ctggaaccac gtagtttcta cacgtggcag gccaagaatg   3000

ggaggctgac tcaaaactag atagaaaaat ataaaataat cttcgaccac ttgatagctc   3060

tcaaatatat atttaaaaga tttatgaata caaaccattt atggtttatg atttctaaaa   3120

agaaagcaca attaatttta tagagaggtt ttttattttt ttaatatttc tattgcaaaa   3180

gtctatccga tttgatgcac tttgaatatt gagatatttt gcacggatga atgtatggga   3240

actacccatg atgatgtaag aggaaagaac atttttttgt gattcaccag acatcacttt   3300

aaacttggtg atgagtttaa atccagtagc taatcccttc ctgagactca aagatcgtga   3360

cgctggttgg aatttctgac tgtgcccttt agggcctcct gagtttcaaa aggaggaagt   3420

gttcgtgctt gtgtccctga agttccctgt tgcatgagcc tgcgacagga cctcaccccc   3480

accaccaggc ttctatttgg gattcacatc agtattagta tcgtagctac accaagttca   3540

ggcttctctt tttgtttttt tacctagaaa ttgggctcag tggtcttcaa cttgaggacg   3600

agggtgattt tcctaagaaa tcagcaaaga gggaaggcag ggcccctgta gattcaccag   3660

tataaacttc agctgcaggg attccagagc cctcgggacc actctgtcac cttaatagcc   3720

aagttctcct ggttcctccg atcttacagg ctcatccagg ttccaaagtg cttctgtctc   3780

tgttttgatt ctccaaactg ctctgtgatg tatgtaggga ttattctccc cacttaacag   3840

aaagtagtgt cttggagagg tcaagggtct ctagttcaat ggccagtcat agcagaaggg   3900

aggccaagca ccagtccatc acccctccca ggccagcctc tgtaagttgg ccacacttgg   3960

ggagtgagtg tgggtatgac tttaccctcc tggttggttc ttactgtttg agtcaaaacc   4020

tcatcaatat atcattgact cctgggttcc tcaggtcatt tcctaatatc tgtccctatc   4080

caatgcctct attttatctt gaaaaaagga ccaaaaatta tttttagcta tggcaaggca   4140

caggccacat ggcccctgat ggcgtccctg ctggttttca attctctgaa gccttgtgta   4200

gctttcagag cacacgtatc ctaattaccc tcctcttcct cagcagaacc catttgagat   4260

tctaaatgaa tactcttagt ctctaaagtt gcagttagaa actaaaataa tgttttttaa   4320

tatgtaatat gctcctcttg gctaattttc ttttgacttt aatgtgccaa tgtaacttcc   4380

tttaaaggat ctatgcattt attaaatctg gaaaactaaa aaaaaaaaaa aaaaaaa      4437


<210>  3193
<211>  558
<212>  PRT
<213>  Homosapiens

<400>  3193

Met Ala Pro Val Asn Gly Thr Gln Thr Ala Lys Asn Cys Thr Asp Pro 
1               5                   10                  15      


Ala Ile His Glu Phe Pro Thr Asp Leu Phe Ser Asn Lys Glu Arg Gln 
            20                  25                  30          


His Gly Ala Val Leu Leu His Ile Leu Gly Ala Leu Tyr Met Phe Tyr 
        35                  40                  45              


Ala Leu Ala Ile Val Cys Asp Asp Phe Phe Val Pro Ser Leu Glu Lys 
    50                  55                  60                  


Ile Cys Glu Arg Leu His Leu Ser Glu Asp Val Ala Gly Ala Thr Phe 
65                  70                  75                  80  


Met Ala Ala Gly Ser Ser Thr Pro Glu Leu Phe Ala Ser Val Ile Gly 
                85                  90                  95      


Val Phe Ile Thr His Gly Asp Val Gly Val Gly Thr Ile Val Gly Ser 
            100                 105                 110         


Ala Val Phe Asn Ile Leu Cys Ile Ile Gly Val Cys Gly Leu Phe Ala 
        115                 120                 125             


Gly Gln Val Val Arg Leu Thr Trp Trp Ala Val Cys Arg Asp Ser Val 
    130                 135                 140                 


Tyr Tyr Thr Ile Ser Val Ile Val Leu Ile Val Phe Ile Tyr Asp Glu 
145                 150                 155                 160 


Gln Ile Val Trp Trp Glu Gly Leu Val Leu Ile Ile Leu Tyr Val Phe 
                165                 170                 175     


Tyr Ile Leu Ile Met Lys Tyr Asn Val Lys Met Gln Ala Phe Phe Thr 
            180                 185                 190         


Val Lys Gln Lys Ser Ile Ala Asn Gly Asn Pro Val Asn Ser Glu Leu 
        195                 200                 205             


Glu Ala Gly Asn Asp Phe Tyr Asp Gly Ser Tyr Asp Asp Pro Ser Val 
    210                 215                 220                 


Pro Leu Leu Gly Gln Val Lys Glu Lys Pro Gln Tyr Gly Lys Asn Pro 
225                 230                 235                 240 


Val Val Met Val Asp Glu Ile Met Ser Ser Ser Pro Pro Lys Phe Thr 
                245                 250                 255     


Phe Pro Glu Ala Gly Leu Arg Ile Met Ile Thr Asn Lys Phe Gly Pro 
            260                 265                 270         


Arg Thr Arg Leu Arg Met Ala Ser Arg Ile Ile Ile Asn Glu Arg Gln 
        275                 280                 285             


Arg Leu Ile Asn Ser Ala Asn Gly Val Ser Ser Lys Pro Leu Gln Asn 
    290                 295                 300                 


Gly Arg His Glu Asn Ile Glu Asn Gly Asn Val Pro Val Glu Asn Pro 
305                 310                 315                 320 


Glu Asp Pro Gln Gln Asn Gln Glu Gln Gln Pro Pro Pro Gln Pro Pro 
                325                 330                 335     


Pro Pro Glu Pro Glu Pro Val Glu Ala Asp Phe Leu Ser Pro Phe Ser 
            340                 345                 350         


Val Pro Glu Ala Arg Gly Asp Lys Val Lys Trp Val Phe Thr Trp Pro 
        355                 360                 365             


Leu Ile Phe Leu Leu Cys Val Thr Ile Pro Asn Cys Ser Lys Pro Arg 
    370                 375                 380                 


Trp Glu Lys Phe Phe Met Val Thr Phe Ile Thr Ala Thr Leu Trp Ile 
385                 390                 395                 400 


Ala Val Phe Ser Tyr Ile Met Val Trp Leu Val Thr Ile Ile Gly Tyr 
                405                 410                 415     


Thr Leu Gly Ile Pro Asp Val Ile Met Gly Ile Thr Phe Leu Ala Ala 
            420                 425                 430         


Gly Thr Ser Val Pro Asp Cys Met Ala Ser Leu Ile Val Ala Arg Gln 
        435                 440                 445             


Gly Leu Gly Asp Met Ala Val Ser Asn Thr Ile Gly Ser Asn Val Phe 
    450                 455                 460                 


Asp Ile Leu Val Gly Leu Gly Val Pro Trp Gly Leu Gln Thr Met Val 
465                 470                 475                 480 


Val Asn Tyr Gly Ser Thr Val Lys Ile Asn Ser Arg Gly Leu Val Tyr 
                485                 490                 495     


Ser Val Val Leu Leu Leu Gly Ser Val Ala Leu Thr Val Leu Gly Ile 
            500                 505                 510         


His Leu Asn Lys Trp Arg Leu Asp Arg Lys Leu Gly Val Tyr Val Leu 
        515                 520                 525             


Val Leu Tyr Ala Ile Phe Leu Cys Phe Ser Ile Met Ile Glu Phe Asn 
    530                 535                 540                 


Val Phe Thr Phe Val Asn Leu Pro Met Cys Arg Glu Asp Asp 
545                 550                 555             


<210>  3194
<211>  3869
<212>  DNA
<213>  Homosapiens

<400>  3194
agaagggagc gagagcccca gagcgcggcg gcagcggcgg cctggccctt ccagagggcc     60

agagccaggg acatgcgggc gcccgggact ccgcgttccg cgcggcccgg cgcctgagcg    120

cctccgttcc ccgtcccgga gctgccggcg gcatgatccg acacgccggg gcgcccgcgc    180

gcggggaccc cacgggtccg gttccagttg ttggcaaagg agaggaagag gaagaggaag    240

atggcatgcg gctttgtctg ccagccaacc cgaaaaactg ccttcctcac cgccggggca    300

tcagcatcct ggagaagctc atcaaaacat gcccggtgtg gctgcagctg agtctgggcc    360

aggcagaggt ggccaggatc ctgcaccggg tggtggctgg gatgttcctg gttcgccggg    420

acagcagctc gaagcagctg gtgctctgtg tccactttcc ttctctgaac gaaagctcgg    480

ccgaggtgct cgaatacacc attaaggaag aaaagtcgat attgtacctg gaaggctcgg    540

ctcttgtgtt tgaggacatc ttcagattga ttgcgttcta ctgtgtcagt agagacttac    600

tgcccttcac actgcggcta ccccaggcca tccttgaggc cagcagcttc acggaccttg    660

agaccatcgc caacctgggt ctgggtttct gggactcctc gctgaatcct ccacaagaaa    720

gagggaagcc agcagagccc ccaagagacc gggcccccgg attcccccta gtctccagcc    780

tcaggcccac agcccatgac gcaaactgtg cctgtgaaat cgagctgtcg gtaggaaatg    840

accgcctgtg gtttgtgaat cctattttca tcgaggactg cagcagcgcc ctgcccaccg    900

accagccacc tcttggaaat tgccctgcac gccctttgcc gcccacctct gatgccacct    960

cacccacctc caggtgggcc ccacgccgcc caccaccccc tcccccagtg ctgcccctgc   1020

agccctgcag cccagcccag ccccctgtgc tccctgctct tgcccccgcc cctgcctgtc   1080

ctttgcccac ctctccccca gtgcctgccc cccacgtcac accccatgcc ccaggtcccc   1140

cagaccatcc gaaccagccg cccatgatga cctgcgagag actcccatgc cccactgcag   1200

gcctgggccc cctcagggag gaagcgatga agccaggggc agcctccagt cccttgcagc   1260

aggtccccgc cccgccactg cctgcgaaga agaaccttcc cactgcccct cccagacgcc   1320

gcgtttccga gagggtgtcc ttagaagacc aaagtccggg gatggcggca gagggggacc   1380

agctcagcct gcctccccaa gggacctcag acggccctga ggacacgccc cgggagagca   1440

cggagcaagg ccaggacaca gaggtgaaag ccagcgatcc tcacagcatg ccagagctgc   1500

ccaggacagc caaacaaccc ccagtcccgc cccccaggaa aaaacggatc tctcgacaac   1560

tggcctcgac cctcccagct cccttagaga acgctgagct ctgcacacag gcgatggcct   1620

tggagacacc cacgccgggt ccacccagag agggccaaag ccctgcttct caggctggga   1680

ctcagcaccc tcctgcccag gccactgccc attcccagag ctctccagag ttcaagggct   1740

ccctggcctc cctctcagac agcttggggg tgtctgtcat ggccaccgac caggactcct   1800

actccaccag cagcacggag gaggagctgg agcagttcag cagccccagc gtgaagaaga   1860

agccctccat gatcctgggc aaggctcggc accggctgag ctttgccagt ttcagcagca   1920

tgttccacgc tttcctctcc aacaaccgca agctgtacaa gaaggtggtg gagctggcgc   1980

aggacaaggg ctcgtacttt ggcagcctgg tgcaggacta caaggtgtac agcctggaga   2040

tgatggcgcg ccagacctcc agcacggaga tgctgcagga gattcgcacc atgatgaccc   2100

agctcaagag ctacctgctg cagagcaccg agctcaaggc cctggtggac cccgccctgc   2160

actccgagga ggagctcgaa gcaattgtag agtctgcctt gtacaaatgt gtcctgaagc   2220

ccctgaagga agccatcaac tcatgcctgc atcagatcca cagcaaggat ggttcgctgc   2280

agcagctcaa ggagaaccag ttagtgatcc tggccaccac caccactgac ctaggtgtga   2340

ccaccagcgt gccggaggtg cccatgatgg agaagatcct gcagaagttc accagcatgc   2400

acaaggccta ctcacctgag aagaagatct ccatcctgct caagacctgc aaactcatct   2460

acgactccat ggccctcggc aacccaggga agccctatgg ggcggatgac ttcctgcctg   2520

tgctcatgta tgtgctggcc cgcagcaacc tcacggagat gcttctcaat gtggagtaca   2580

tgatggagct catggacccc gccctgcagc tgggggaggg ttcctactat ctgaccacca   2640

cctacggggc cctggagcac atcaagagct acgacaagat cacggtgacc cggcagctga   2700

gtgtggaggt gcaggactcc atccaccgct gggagcgccg gcgtactctc aacaaggccc   2760

gggcctcccg ctcctccgta caggacttca tctgcgtgtc gtacctggag cccgagcagc   2820

aggcgcggac gctggcgtcg cgggcggaca cccaggccca ggcgctgtgc gcgcagtgcg   2880

cggagaagtt cgcggtggag cggccgcagg cgcaccggct gttcgtgctg gtggacgggc   2940

gctgcttcca gctggcggac gacgcgctgc cgcactgcat caagggctac ctgctgcgca   3000

gcgagcccaa gcgcgacttc cactttgtct accggcccct ggacggtggt ggcggcggcg   3060

gcggcgggag cccgccctgc ctggtggtgc gggagcccaa cttcctgtga ggccctcccg   3120

gggcgcctcc cctcaccccc aggcgcacgt ctggccccgc ctctggctgc gcactcccga   3180

ccgcgacgtc cacgcagcag agggacatgg gccattccat gacgtgccca ggccaacgtc   3240

gcaggacagt tgtgaaaata acatgacgct cgtccaaggc cacttcctga gggcaagtcc   3300

taatagccct gagacaccga gacggcatgt tcttcattag acggaaaggg aaactgaggc   3360

tcaggagaga ggcgctccag gccgctgcag ccaacaaacc ggcgccctct tcacacgtag   3420

ctcctcaggc cattccccat gagtccccca cacccacccc atcctcggtc tttgcaaaga   3480

agggcccgag cttagtttcc ccaggactgg cctaggaagg agcaccggcc acagctgctc   3540

cccgtgccac tcagggtgga cccagcatct caggagcacc tcagggtgtc ggttaagaga   3600

caggcctcca cccctgcacc agagcctgct cttagctccc ggtgccccca gaccccgcag   3660

ctctgtgccc ggcaagaagc agctagacac acgccagggc gccaagcacg gccagctccg   3720

cggacccatg gacaagccca gccccgcctc agggaaaaca gggcctttcc ctacaggaca   3780

cgccccagag ctgtggcaga ttgcaggagc catcgtgtgg ggagaattta ataaaagccc   3840

ttttgaaaaa aaaaaaaaaa aaaaaaaaa                                     3869


<210>  3195
<211>  985
<212>  PRT
<213>  Homosapiens

<400>  3195

Met Ile Arg His Ala Gly Ala Pro Ala Arg Gly Asp Pro Thr Gly Pro 
1               5                   10                  15      


Val Pro Val Val Gly Lys Gly Glu Glu Glu Glu Glu Glu Asp Gly Met 
            20                  25                  30          


Arg Leu Cys Leu Pro Ala Asn Pro Lys Asn Cys Leu Pro His Arg Arg 
        35                  40                  45              


Gly Ile Ser Ile Leu Glu Lys Leu Ile Lys Thr Cys Pro Val Trp Leu 
    50                  55                  60                  


Gln Leu Ser Leu Gly Gln Ala Glu Val Ala Arg Ile Leu His Arg Val 
65                  70                  75                  80  


Val Ala Gly Met Phe Leu Val Arg Arg Asp Ser Ser Ser Lys Gln Leu 
                85                  90                  95      


Val Leu Cys Val His Phe Pro Ser Leu Asn Glu Ser Ser Ala Glu Val 
            100                 105                 110         


Leu Glu Tyr Thr Ile Lys Glu Glu Lys Ser Ile Leu Tyr Leu Glu Gly 
        115                 120                 125             


Ser Ala Leu Val Phe Glu Asp Ile Phe Arg Leu Ile Ala Phe Tyr Cys 
    130                 135                 140                 


Val Ser Arg Asp Leu Leu Pro Phe Thr Leu Arg Leu Pro Gln Ala Ile 
145                 150                 155                 160 


Leu Glu Ala Ser Ser Phe Thr Asp Leu Glu Thr Ile Ala Asn Leu Gly 
                165                 170                 175     


Leu Gly Phe Trp Asp Ser Ser Leu Asn Pro Pro Gln Glu Arg Gly Lys 
            180                 185                 190         


Pro Ala Glu Pro Pro Arg Asp Arg Ala Pro Gly Phe Pro Leu Val Ser 
        195                 200                 205             


Ser Leu Arg Pro Thr Ala His Asp Ala Asn Cys Ala Cys Glu Ile Glu 
    210                 215                 220                 


Leu Ser Val Gly Asn Asp Arg Leu Trp Phe Val Asn Pro Ile Phe Ile 
225                 230                 235                 240 


Glu Asp Cys Ser Ser Ala Leu Pro Thr Asp Gln Pro Pro Leu Gly Asn 
                245                 250                 255     


Cys Pro Ala Arg Pro Leu Pro Pro Thr Ser Asp Ala Thr Ser Pro Thr 
            260                 265                 270         


Ser Arg Trp Ala Pro Arg Arg Pro Pro Pro Pro Pro Pro Val Leu Pro 
        275                 280                 285             


Leu Gln Pro Cys Ser Pro Ala Gln Pro Pro Val Leu Pro Ala Leu Ala 
    290                 295                 300                 


Pro Ala Pro Ala Cys Pro Leu Pro Thr Ser Pro Pro Val Pro Ala Pro 
305                 310                 315                 320 


His Val Thr Pro His Ala Pro Gly Pro Pro Asp His Pro Asn Gln Pro 
                325                 330                 335     


Pro Met Met Thr Cys Glu Arg Leu Pro Cys Pro Thr Ala Gly Leu Gly 
            340                 345                 350         


Pro Leu Arg Glu Glu Ala Met Lys Pro Gly Ala Ala Ser Ser Pro Leu 
        355                 360                 365             


Gln Gln Val Pro Ala Pro Pro Leu Pro Ala Lys Lys Asn Leu Pro Thr 
    370                 375                 380                 


Ala Pro Pro Arg Arg Arg Val Ser Glu Arg Val Ser Leu Glu Asp Gln 
385                 390                 395                 400 


Ser Pro Gly Met Ala Ala Glu Gly Asp Gln Leu Ser Leu Pro Pro Gln 
                405                 410                 415     


Gly Thr Ser Asp Gly Pro Glu Asp Thr Pro Arg Glu Ser Thr Glu Gln 
            420                 425                 430         


Gly Gln Asp Thr Glu Val Lys Ala Ser Asp Pro His Ser Met Pro Glu 
        435                 440                 445             


Leu Pro Arg Thr Ala Lys Gln Pro Pro Val Pro Pro Pro Arg Lys Lys 
    450                 455                 460                 


Arg Ile Ser Arg Gln Leu Ala Ser Thr Leu Pro Ala Pro Leu Glu Asn 
465                 470                 475                 480 


Ala Glu Leu Cys Thr Gln Ala Met Ala Leu Glu Thr Pro Thr Pro Gly 
                485                 490                 495     


Pro Pro Arg Glu Gly Gln Ser Pro Ala Ser Gln Ala Gly Thr Gln His 
            500                 505                 510         


Pro Pro Ala Gln Ala Thr Ala His Ser Gln Ser Ser Pro Glu Phe Lys 
        515                 520                 525             


Gly Ser Leu Ala Ser Leu Ser Asp Ser Leu Gly Val Ser Val Met Ala 
    530                 535                 540                 


Thr Asp Gln Asp Ser Tyr Ser Thr Ser Ser Thr Glu Glu Glu Leu Glu 
545                 550                 555                 560 


Gln Phe Ser Ser Pro Ser Val Lys Lys Lys Pro Ser Met Ile Leu Gly 
                565                 570                 575     


Lys Ala Arg His Arg Leu Ser Phe Ala Ser Phe Ser Ser Met Phe His 
            580                 585                 590         


Ala Phe Leu Ser Asn Asn Arg Lys Leu Tyr Lys Lys Val Val Glu Leu 
        595                 600                 605             


Ala Gln Asp Lys Gly Ser Tyr Phe Gly Ser Leu Val Gln Asp Tyr Lys 
    610                 615                 620                 


Val Tyr Ser Leu Glu Met Met Ala Arg Gln Thr Ser Ser Thr Glu Met 
625                 630                 635                 640 


Leu Gln Glu Ile Arg Thr Met Met Thr Gln Leu Lys Ser Tyr Leu Leu 
                645                 650                 655     


Gln Ser Thr Glu Leu Lys Ala Leu Val Asp Pro Ala Leu His Ser Glu 
            660                 665                 670         


Glu Glu Leu Glu Ala Ile Val Glu Ser Ala Leu Tyr Lys Cys Val Leu 
        675                 680                 685             


Lys Pro Leu Lys Glu Ala Ile Asn Ser Cys Leu His Gln Ile His Ser 
    690                 695                 700                 


Lys Asp Gly Ser Leu Gln Gln Leu Lys Glu Asn Gln Leu Val Ile Leu 
705                 710                 715                 720 


Ala Thr Thr Thr Thr Asp Leu Gly Val Thr Thr Ser Val Pro Glu Val 
                725                 730                 735     


Pro Met Met Glu Lys Ile Leu Gln Lys Phe Thr Ser Met His Lys Ala 
            740                 745                 750         


Tyr Ser Pro Glu Lys Lys Ile Ser Ile Leu Leu Lys Thr Cys Lys Leu 
        755                 760                 765             


Ile Tyr Asp Ser Met Ala Leu Gly Asn Pro Gly Lys Pro Tyr Gly Ala 
    770                 775                 780                 


Asp Asp Phe Leu Pro Val Leu Met Tyr Val Leu Ala Arg Ser Asn Leu 
785                 790                 795                 800 


Thr Glu Met Leu Leu Asn Val Glu Tyr Met Met Glu Leu Met Asp Pro 
                805                 810                 815     


Ala Leu Gln Leu Gly Glu Gly Ser Tyr Tyr Leu Thr Thr Thr Tyr Gly 
            820                 825                 830         


Ala Leu Glu His Ile Lys Ser Tyr Asp Lys Ile Thr Val Thr Arg Gln 
        835                 840                 845             


Leu Ser Val Glu Val Gln Asp Ser Ile His Arg Trp Glu Arg Arg Arg 
    850                 855                 860                 


Thr Leu Asn Lys Ala Arg Ala Ser Arg Ser Ser Val Gln Asp Phe Ile 
865                 870                 875                 880 


Cys Val Ser Tyr Leu Glu Pro Glu Gln Gln Ala Arg Thr Leu Ala Ser 
                885                 890                 895     


Arg Ala Asp Thr Gln Ala Gln Ala Leu Cys Ala Gln Cys Ala Glu Lys 
            900                 905                 910         


Phe Ala Val Glu Arg Pro Gln Ala His Arg Leu Phe Val Leu Val Asp 
        915                 920                 925             


Gly Arg Cys Phe Gln Leu Ala Asp Asp Ala Leu Pro His Cys Ile Lys 
    930                 935                 940                 


Gly Tyr Leu Leu Arg Ser Glu Pro Lys Arg Asp Phe His Phe Val Tyr 
945                 950                 955                 960 


Arg Pro Leu Asp Gly Gly Gly Gly Gly Gly Gly Gly Ser Pro Pro Cys 
                965                 970                 975     


Leu Val Val Arg Glu Pro Asn Phe Leu 
            980                 985 


<210>  3196
<211>  3175
<212>  DNA
<213>  Homosapiens

<400>  3196
gcccctgcag gtgccatgac tcagcagccc caggacgact ttgacaggag cgtggaggat     60

gcccaggcat ggatgaaggc tgtgcaggac cagctgcagg tcaatgacaa cacgcaggga    120

ccccgcgcgg ccctggaggc caggctgtgg gagaccgaga aaatatgcca gctggagccc    180

gaggggcgtg tgagggtgga cctcgtgcta cggatggctg aagccctctt ggcatgctgc    240

cctggggacc agaagcccgg gatcctggcc cggctgaagg acatcaaggc ccaatgggag    300

gagacagtca cctacatgac tcactgtcac agccgcatcg agtgggtgtg gctgcactgg    360

agcgagtacc tgctggcccg agatgagttc taccgctggt tccagaagat gatggtcaca    420

ctggagcccc acatcgagct ccagctgggc ctgaaggaga agcagtggca gctgagccac    480

gcccaggtgc tgctgcacaa cgtggacaac caggcggtgc tcctggaccg gctgctggag    540

gaggcagcct ccctgttcaa caggatcggg gaccccagcg tggacgaaga tgcccagaag    600

agaatgaagg ctgagtacga tgcagtgaag gccaaggccc agaagcgtgt agatctgctg    660

gagcaggtgg cccgggagca tgaggagtac caggcaggtg tggacgagtt ccaactgtgg    720

ctgaaggcgg tggtggagaa ggtgaatggc tgcctggggc ggaactgcaa gctgcccatc    780

acgcagcgcc tctccacact gcaggacatt gccaaagatt ttcccagggg cgaggagtct    840

ctggagacgc tggaggagca gtctgcgggt gtcattcgga acacctctcc tttgggtgca    900

gagaagatca ccggagaact ggaagagatg aggaaagttc tggagaagct gcgcgccctc    960

tgggaggagg aggaggagcg gctgcggggc ctgctccggt ccaggggagc ctgggagcag   1020

cagattaagc agctggaggc tgagctcagt gagttcagga tggtcctgca gaggctggcc   1080

caggagggcc tgcagcctgc ggcgaaagcg gggaccgagg acgagctggt ggcacactgg   1140

agacgctact cggcaacacg ggcggcgctg gcctcggagg agccccgggt ggaccggctg   1200

caagcccagc tgaaggagct catcgtcttc cctcacaacc tgaagccact ctctgatagt   1260

gtcatcgcta ccatccagga gtatcagagc ctgaaggtga agagcgcgag gctgcgcaat   1320

gccgcggcgg tggagctgtg gcagcatttc cagcggcctc tgcaggatct gcagctgtgg   1380

aaggccctgg cccagcggct cttggaggtc actgccagcc tgccggacct gccttccctt   1440

cacaccttcc tgccccagat cgaggcagcc ctgatggaaa gctcccgcct gaaagagctg   1500

ctgacgatgc tgcagctgaa gaaagacctc ctgattggca tctttggcca ggagagagcc   1560

acggcactcc tggagcaggt ggcaggttcc atgagggaca gagacctgct gcataacagc   1620

ctcctgcaga ggaaaagcaa actgcagagc ctgctcgctc agcacaaaga ctttggagca   1680

gcttttgagc ccctgcagag gaagctcttg gacctccagg tcagggtcca agccgagaag   1740

gggcttcagc gggaccttcc tggaaaacag gcccagctct caaggttgca ggggctgcag   1800

gaagaggggc tggacttggg ggcacagatg gaggctgcaa ggcctctggt ccaggagaac   1860

cccaaccacc agcacaaaat ggaccagctt tcctccgact tccaggccct gcagaggtct   1920

ctggaggacc ttgtggacag gtgtcggcag agtgtgcagg agcactgcac cttcagccac   1980

cagctgctgg agctgcggca gtggatcgtt gtgaccacgc aaaagctgga ggcacaccgg   2040

ggagaggcgg gcccggggga tgccgagtcc caagaggccg agtttgagag gctggtggca   2100

gaattcccgg agaaggaggc ccagctgtcc ctggtggaag cgcagggctg gctggtgatg   2160

gagaagtctt ctccggaggg tgctgccgtg gtgcaggagg agctcaggga gctggcagag   2220

tcgtggcggg ccttgaggct gctggaagaa agtctgctga gcctcatcag aaactggcat   2280

ctgcagagga tggaagtgga ttcggggaag aaaatggttt tcaccaacaa catcccaaag   2340

tcaggatttc tcatcaatcc catggatcct attcccaggc atcgtcgacg cgcaaatctt   2400

ctacaggaag aagaagggag ccatgaagat ttctcccagc tcctgaggaa ctttgggcag   2460

tggttgcagg tggaaaactc caagctggtt agaatcatcg caatgagaac ttctacagct   2520

gaggacttga ggaccagaaa atcgaagctg caggagctgg aggctcgggt gccagaaggt   2580

cagcatctct ttgagaacct ccttcgtctc gggccagcaa gggggacctc ggatgagctg   2640

gaagatctgc gctaccagtg gatgctgtac aagtccaagc tgaaggactc tggccacctg   2700

ctgacacaaa gttctccagg ggagccgact ggattccaaa agactcggcg gtggcgagga   2760

ctgggctccc tcttccggag ggtgtgctgt gtggcgctcc cactgcagct gcttctgctg   2820

ctgttcctcc tcctgctgtt cctgctccca atcagggaag aggaccgcag ctgcaccctg   2880

gccaacaact tcgcccgctc cttcacgctc atgctgcgct acaatggccc accacccacc   2940

taacccactg gggcacacag gtgactttct cctccaacct ccatcagtcc cagggcccct   3000

cctggggatg ctcgccaggg aaactggaaa caggggcagg gcaaagactg cagagctgca   3060

tccatatcag tgctgtgtca gcgttcccag aagacactta ctttttatac agtgttgtct   3120

tagtctattt atactaaatg tgtactacat gtgactaggg aaaaaaaaaa aaaag        3175


<210>  3197
<211>  975
<212>  PRT
<213>  Homosapiens

<400>  3197

Met Thr Gln Gln Pro Gln Asp Asp Phe Asp Arg Ser Val Glu Asp Ala 
1               5                   10                  15      


Gln Ala Trp Met Lys Ala Val Gln Asp Gln Leu Gln Val Asn Asp Asn 
            20                  25                  30          


Thr Gln Gly Pro Arg Ala Ala Leu Glu Ala Arg Leu Trp Glu Thr Glu 
        35                  40                  45              


Lys Ile Cys Gln Leu Glu Pro Glu Gly Arg Val Arg Val Asp Leu Val 
    50                  55                  60                  


Leu Arg Met Ala Glu Ala Leu Leu Ala Cys Cys Pro Gly Asp Gln Lys 
65                  70                  75                  80  


Pro Gly Ile Leu Ala Arg Leu Lys Asp Ile Lys Ala Gln Trp Glu Glu 
                85                  90                  95      


Thr Val Thr Tyr Met Thr His Cys His Ser Arg Ile Glu Trp Val Trp 
            100                 105                 110         


Leu His Trp Ser Glu Tyr Leu Leu Ala Arg Asp Glu Phe Tyr Arg Trp 
        115                 120                 125             


Phe Gln Lys Met Met Val Thr Leu Glu Pro His Ile Glu Leu Gln Leu 
    130                 135                 140                 


Gly Leu Lys Glu Lys Gln Trp Gln Leu Ser His Ala Gln Val Leu Leu 
145                 150                 155                 160 


His Asn Val Asp Asn Gln Ala Val Leu Leu Asp Arg Leu Leu Glu Glu 
                165                 170                 175     


Ala Ala Ser Leu Phe Asn Arg Ile Gly Asp Pro Ser Val Asp Glu Asp 
            180                 185                 190         


Ala Gln Lys Arg Met Lys Ala Glu Tyr Asp Ala Val Lys Ala Lys Ala 
        195                 200                 205             


Gln Lys Arg Val Asp Leu Leu Glu Gln Val Ala Arg Glu His Glu Glu 
    210                 215                 220                 


Tyr Gln Ala Gly Val Asp Glu Phe Gln Leu Trp Leu Lys Ala Val Val 
225                 230                 235                 240 


Glu Lys Val Asn Gly Cys Leu Gly Arg Asn Cys Lys Leu Pro Ile Thr 
                245                 250                 255     


Gln Arg Leu Ser Thr Leu Gln Asp Ile Ala Lys Asp Phe Pro Arg Gly 
            260                 265                 270         


Glu Glu Ser Leu Glu Thr Leu Glu Glu Gln Ser Ala Gly Val Ile Arg 
        275                 280                 285             


Asn Thr Ser Pro Leu Gly Ala Glu Lys Ile Thr Gly Glu Leu Glu Glu 
    290                 295                 300                 


Met Arg Lys Val Leu Glu Lys Leu Arg Ala Leu Trp Glu Glu Glu Glu 
305                 310                 315                 320 


Glu Arg Leu Arg Gly Leu Leu Arg Ser Arg Gly Ala Trp Glu Gln Gln 
                325                 330                 335     


Ile Lys Gln Leu Glu Ala Glu Leu Ser Glu Phe Arg Met Val Leu Gln 
            340                 345                 350         


Arg Leu Ala Gln Glu Gly Leu Gln Pro Ala Ala Lys Ala Gly Thr Glu 
        355                 360                 365             


Asp Glu Leu Val Ala His Trp Arg Arg Tyr Ser Ala Thr Arg Ala Ala 
    370                 375                 380                 


Leu Ala Ser Glu Glu Pro Arg Val Asp Arg Leu Gln Ala Gln Leu Lys 
385                 390                 395                 400 


Glu Leu Ile Val Phe Pro His Asn Leu Lys Pro Leu Ser Asp Ser Val 
                405                 410                 415     


Ile Ala Thr Ile Gln Glu Tyr Gln Ser Leu Lys Val Lys Ser Ala Arg 
            420                 425                 430         


Leu Arg Asn Ala Ala Ala Val Glu Leu Trp Gln His Phe Gln Arg Pro 
        435                 440                 445             


Leu Gln Asp Leu Gln Leu Trp Lys Ala Leu Ala Gln Arg Leu Leu Glu 
    450                 455                 460                 


Val Thr Ala Ser Leu Pro Asp Leu Pro Ser Leu His Thr Phe Leu Pro 
465                 470                 475                 480 


Gln Ile Glu Ala Ala Leu Met Glu Ser Ser Arg Leu Lys Glu Leu Leu 
                485                 490                 495     


Thr Met Leu Gln Leu Lys Lys Asp Leu Leu Ile Gly Ile Phe Gly Gln 
            500                 505                 510         


Glu Arg Ala Thr Ala Leu Leu Glu Gln Val Ala Gly Ser Met Arg Asp 
        515                 520                 525             


Arg Asp Leu Leu His Asn Ser Leu Leu Gln Arg Lys Ser Lys Leu Gln 
    530                 535                 540                 


Ser Leu Leu Ala Gln His Lys Asp Phe Gly Ala Ala Phe Glu Pro Leu 
545                 550                 555                 560 


Gln Arg Lys Leu Leu Asp Leu Gln Val Arg Val Gln Ala Glu Lys Gly 
                565                 570                 575     


Leu Gln Arg Asp Leu Pro Gly Lys Gln Ala Gln Leu Ser Arg Leu Gln 
            580                 585                 590         


Gly Leu Gln Glu Glu Gly Leu Asp Leu Gly Ala Gln Met Glu Ala Ala 
        595                 600                 605             


Arg Pro Leu Val Gln Glu Asn Pro Asn His Gln His Lys Met Asp Gln 
    610                 615                 620                 


Leu Ser Ser Asp Phe Gln Ala Leu Gln Arg Ser Leu Glu Asp Leu Val 
625                 630                 635                 640 


Asp Arg Cys Arg Gln Ser Val Gln Glu His Cys Thr Phe Ser His Gln 
                645                 650                 655     


Leu Leu Glu Leu Arg Gln Trp Ile Val Val Thr Thr Gln Lys Leu Glu 
            660                 665                 670         


Ala His Arg Gly Glu Ala Gly Pro Gly Asp Ala Glu Ser Gln Glu Ala 
        675                 680                 685             


Glu Phe Glu Arg Leu Val Ala Glu Phe Pro Glu Lys Glu Ala Gln Leu 
    690                 695                 700                 


Ser Leu Val Glu Ala Gln Gly Trp Leu Val Met Glu Lys Ser Ser Pro 
705                 710                 715                 720 


Glu Gly Ala Ala Val Val Gln Glu Glu Leu Arg Glu Leu Ala Glu Ser 
                725                 730                 735     


Trp Arg Ala Leu Arg Leu Leu Glu Glu Ser Leu Leu Ser Leu Ile Arg 
            740                 745                 750         


Asn Trp His Leu Gln Arg Met Glu Val Asp Ser Gly Lys Lys Met Val 
        755                 760                 765             


Phe Thr Asn Asn Ile Pro Lys Ser Gly Phe Leu Ile Asn Pro Met Asp 
    770                 775                 780                 


Pro Ile Pro Arg His Arg Arg Arg Ala Asn Leu Leu Gln Glu Glu Glu 
785                 790                 795                 800 


Gly Ser His Glu Asp Phe Ser Gln Leu Leu Arg Asn Phe Gly Gln Trp 
                805                 810                 815     


Leu Gln Val Glu Asn Ser Lys Leu Val Arg Ile Ile Ala Met Arg Thr 
            820                 825                 830         


Ser Thr Ala Glu Asp Leu Arg Thr Arg Lys Ser Lys Leu Gln Glu Leu 
        835                 840                 845             


Glu Ala Arg Val Pro Glu Gly Gln His Leu Phe Glu Asn Leu Leu Arg 
    850                 855                 860                 


Leu Gly Pro Ala Arg Gly Thr Ser Asp Glu Leu Glu Asp Leu Arg Tyr 
865                 870                 875                 880 


Gln Trp Met Leu Tyr Lys Ser Lys Leu Lys Asp Ser Gly His Leu Leu 
                885                 890                 895     


Thr Gln Ser Ser Pro Gly Glu Pro Thr Gly Phe Gln Lys Thr Arg Arg 
            900                 905                 910         


Trp Arg Gly Leu Gly Ser Leu Phe Arg Arg Val Cys Cys Val Ala Leu 
        915                 920                 925             


Pro Leu Gln Leu Leu Leu Leu Leu Phe Leu Leu Leu Leu Phe Leu Leu 
    930                 935                 940                 


Pro Ile Arg Glu Glu Asp Arg Ser Cys Thr Leu Ala Asn Asn Phe Ala 
945                 950                 955                 960 


Arg Ser Phe Thr Leu Met Leu Arg Tyr Asn Gly Pro Pro Pro Thr 
                965                 970                 975 


<210>  3198
<211>  1627
<212>  DNA
<213>  Homosapiens

<400>  3198
gtccggagca ctccttccct tccctggttc ctcaaggcac ggctccccca ggcagatgaa     60

agcttaatag agttttgcga catgaaagtc agtcggagga aagagccttg aacagttgtg    120

cgtgagagag aggcaagcgc ccgaaattat tttacgacaa aggcagctct ctctgccaca    180

gaggcacaga ggagaaagga gcccaggaaa cgggtcattt ctttcgtgga aaaatggaaa    240

tgctctgaag cattttggga gacgtgctgt gaagcaggtg acaccagaag acaaggacac    300

tgggggctcc ctgccgggag gcgcaaaaag caactcccgt tcgagggtca gaggagcctg    360

gatgctaatg tctctccaaa gtgacttgga gccaactgcc ggaaaggcca tgcccttagg    420

agcacaggca ggtcccagct cagggatcaa gaggtctgct gtgtgacctt cttcaagttc    480

ctgaccctct ctgggctgca gtcaccttat tcagaaaatg gagaggctag acaagaaaat    540

gatgctaatc tcaccctttt ctgggctggc attttattga gcacctacta ggcgctgggc    600

attttgctag gcccttcgtg cacactgcca tgagaaatcc acagcaaccc cagagatggg    660

ttcatcaata actcaccagc aaatacttcc tgaggcccca ctgtgtgccg agcatgggca    720

taggtactgg gcacacctcg atgaacaagg gaggtaagga tgtgactctc ctagaacttt    780

ctgtcgagaa gaggagatgg agaataaaca tggaaacaag caagatcatt ctggagaaaa    840

tgcaatcaga tgatgtgcta gatggtaaca gagagaggtc gaatgagaga gagggccgtg    900

acagcctctc tgagaagctg aaatccaagc agaacctgaa agacgaggag aaactcagat    960

acataaagac tgggaaaagc attcaagtag agggaacagt gcgtgcaaag gccctgaggt   1020

gggtgcagta gataccacag gccccctcac tcgagaccac tccaagcacc tcctgccctc   1080

ttgtgccaca gagctcagaa agctaaagca atgttcccca gaggtcctgt ggccaaggtc   1140

ctgcatgggc ctgggtgacc cctgcagaag cttctgagca agactgagca gggaaagaaa   1200

ggccatgtca gaaaaccatc ctccagcgag catggaggca gagagtctca tcctggcatc   1260

ccaggtgctg agcagagcag acagcagcag aggggctccc tagagcagct gggggccctg   1320

cctgtgccgt cgctctttcc cctccctgcc ctctggtctg acatcccatt ggcatcacac   1380

acgatgcctc ccggaggtgc tcttgtgcac acagcaggtc aaagtgccag agaattagat   1440

cctgtcctct tgggaacagc cctcagccag cagtgagccc ttaggaggat gctccaagct   1500

ctatcctccc cgggtccaga ggccctggga tggagcgcca ttgtggaagc agtgacaact   1560

tgatgaagct ccctgggctg gccccttcct ctctgccttg ttccccgttc cctgcagtcc   1620

tgcaatc                                                             1627


<210>  3199
<211>  105
<212>  PRT
<213>  Homosapiens

<400>  3199

Met Gly Ile Gly Thr Gly His Thr Ser Met Asn Lys Gly Gly Lys Asp 
1               5                   10                  15      


Val Thr Leu Leu Glu Leu Ser Val Glu Lys Arg Arg Trp Arg Ile Asn 
            20                  25                  30          


Met Glu Thr Ser Lys Ile Ile Leu Glu Lys Met Gln Ser Asp Asp Val 
        35                  40                  45              


Leu Asp Gly Asn Arg Glu Arg Ser Asn Glu Arg Glu Gly Arg Asp Ser 
    50                  55                  60                  


Leu Ser Glu Lys Leu Lys Ser Lys Gln Asn Leu Lys Asp Glu Glu Lys 
65                  70                  75                  80  


Leu Arg Tyr Ile Lys Thr Gly Lys Ser Ile Gln Val Glu Gly Thr Val 
                85                  90                  95      


Arg Ala Lys Ala Leu Arg Trp Val Gln 
            100                 105 


<210>  3200
<211>  1352
<212>  DNA
<213>  Homosapiens

<400>  3200
ggcagctccc cggcagcggc ggtggagagc gcagcgcgca gcccggtgca gccctggctt     60

tcccctcgct gcgcgcccgc gccccctttc gcgtccgcaa ccagaagccc agtgcggcgc    120

caggagccgg acccgcgccc gcaccgctcc cgggaccgcg accccggccg cccagagatg    180

accgcgaccg aagccctcct gcgcgtcctc ttgctcctgc tggctttcgg ccacagcacc    240

tatggggctg aatgcttccc ggcctgcaac ccccaaaatg gattctgcga ggatgacaat    300

gtttgcaggt gccagcctgg ctggcagggt cccctttgtg accagtgcgt gacctctccc    360

ggctgccttc acggactctg tggagaaccc gggcagtgca tttgcaccga cggctgggac    420

ggggagctct gtgatagaga tgttcgggcc tgctcctcgg ccccctgtgc caacaacggg    480

acctgcgtga gcctggacga tggcctctat gaatgctcct gtgcccccgg gtactcggga    540

aaggactgcc agaaaaagga cgggccctgt gtgatcaacg gctccccctg ccagcacgga    600

ggcacctgcg tggatgatga gggccgggcc tcccatgcct cctgcctgtg cccccctggc    660

ttctcaggca atttctgcga gatcgtggcc aacagctgca cccccaaccc atgcgagaac    720

gacggcgtct gcactgacat tgggggcgac ttccgctgcc ggtgcccagc cggcttcatc    780

gacaagacct gcagcagccg gagcaccgca tcctgaaggt gtccatgaaa gagctcaaca    840

agaaaacccc tctcctcacc gagggccagg ccatctgctt caccatcctg ggcgtgctca    900

ccagcctggt ggtgctgggc actgtgggta tcgtcttcct caacaagtgc gagacctggg    960

tgtccaacct gcgctacaac cacatgctgc ggaagaagaa gaacctgctg cttcagtaca   1020

acagcgggga ggacctggcc gtcaacatca tcttccccga gaagatcgac atgaccacct   1080

tcagcaagga ggccggcgac gaggagatct aagcagcgtt cccacagccc cctctagatt   1140

cttggagttc cgcagagctt actatacgcg gtctgtccta atctttgtgg tgttcgctat   1200

ctcttgtgtc aaatctggtg aacgctacgc ttacatatat tgtctttgtg ctgctgtgtg   1260

acaaacgcaa tgcaaaaaca atcctctttc tctctcttaa tgcatgatac agaataataa   1320

taagaatttc atctttaaat gagtaagaga aa                                 1352


<210>  3201
<211>  212
<212>  PRT
<213>  Homosapiens

<400>  3201

Met Thr Ala Thr Glu Ala Leu Leu Arg Val Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gly His Ser Thr Tyr Gly Ala Glu Cys Phe Pro Ala Cys Asn Pro 
            20                  25                  30          


Gln Asn Gly Phe Cys Glu Asp Asp Asn Val Cys Arg Cys Gln Pro Gly 
        35                  40                  45              


Trp Gln Gly Pro Leu Cys Asp Gln Cys Val Thr Ser Pro Gly Cys Leu 
    50                  55                  60                  


His Gly Leu Cys Gly Glu Pro Gly Gln Cys Ile Cys Thr Asp Gly Trp 
65                  70                  75                  80  


Asp Gly Glu Leu Cys Asp Arg Asp Val Arg Ala Cys Ser Ser Ala Pro 
                85                  90                  95      


Cys Ala Asn Asn Gly Thr Cys Val Ser Leu Asp Asp Gly Leu Tyr Glu 
            100                 105                 110         


Cys Ser Cys Ala Pro Gly Tyr Ser Gly Lys Asp Cys Gln Lys Lys Asp 
        115                 120                 125             


Gly Pro Cys Val Ile Asn Gly Ser Pro Cys Gln His Gly Gly Thr Cys 
    130                 135                 140                 


Val Asp Asp Glu Gly Arg Ala Ser His Ala Ser Cys Leu Cys Pro Pro 
145                 150                 155                 160 


Gly Phe Ser Gly Asn Phe Cys Glu Ile Val Ala Asn Ser Cys Thr Pro 
                165                 170                 175     


Asn Pro Cys Glu Asn Asp Gly Val Cys Thr Asp Ile Gly Gly Asp Phe 
            180                 185                 190         


Arg Cys Arg Cys Pro Ala Gly Phe Ile Asp Lys Thr Cys Ser Ser Arg 
        195                 200                 205             


Ser Thr Ala Ser 
    210         


<210>  3202
<211>  1532
<212>  DNA
<213>  Homosapiens

<400>  3202
gagagcgcag cgcgcagccc ggtgcagccc tggctttccc ctcgctgcgc gcccgcgccc     60

cctttcgcgt ccgcaaccag aagcccagtg cggcgccagg agccggaccc gcgcccgcac    120

cgctcccggg accgcgaccc cggccgccca gagatgaccg cgaccgaagc cctcctgcgc    180

gtcctcttgc tcctgctggc tttcggccac agcacctatg gggctgaatg cttcccggcc    240

tgcaaccccc aaaatggatt ctgcgaggat gacaatgttt gcaggtgcca gcctggctgg    300

cagggtcccc tttgtgacca gtgcgtgacc tctcccggct gccttcacgg actctgtgga    360

gaacccgggc agtgcatttg caccgacggc tgggacgggg agctctgtga tagagatgtt    420

cgggcctgct cctcggcccc ctgtgccaac aacgggacct gcgtgagcct ggacgatggc    480

ctctatgaat gctcctgtgc ccccgggtac tcgggaaagg actgccagaa aaaggacggg    540

ccctgtgtga tcaacggctc cccctgccag cacggaggca cctgcgtgga tgatgagggc    600

cgggcctccc atgcctcctg cctgtgcccc cctggcttct caggcaattt ctgcgagatc    660

gtggccaaca gctgcacccc caacccatgc gagaacgacg gcgtctgcac tgacattggg    720

ggcgacttcc gctgccggtg cccagccggc ttcatcgaca agacctgcag ccgcccggtg    780

accaactgcg ccagcagccc gtgccagaac gggggcacct gcctgcagca cacccaggtg    840

agctacgagt gtctgtgcaa gcccgagttc acaggtctca cctgtgtcaa gaagcgcgcg    900

ctgagccccc agcaggtcac ccgtctgccc agcggctatg ggctggccta ccgcctgacc    960

cctggggtgc acgagctgcc ggtgcagcag ccggagcacc gcatcctgaa ggtgtccatg   1020

aaagagctca acaagaaaac ccctctcctc accgagggcc aggccatctg cttcaccatc   1080

ctgggcgtgc tcaccagcct ggtggtgctg ggcactgtgg gtatcgtctt cctcaacaag   1140

tgcgagacct gggtgtccaa cctgcgctac aaccacatgc tgcggaagaa gaagaacctg   1200

ctgcttcagt acaacagcgg ggaggacctg gccgtcaaca tcatcttccc cgagaagatc   1260

gacatgacca ccttcagcaa ggaggccggc gacgaggaga tctaagcagc gttcccacag   1320

ccccctctag attcttggag ttccgcagag cttactatac gcggtctgtc ctaatctttg   1380

tggtgttcgc tatctcttgt gtcaaatctg gtgaacgcta cgcttacata tattgtcttt   1440

gtgctgctgt gtgacaaacg caatgcaaaa acaatcctct ttctctctct taatgcatga   1500

tacagaataa taataagaat ttcatcttta aa                                 1532


<210>  3203
<211>  383
<212>  PRT
<213>  Homosapiens

<400>  3203

Met Thr Ala Thr Glu Ala Leu Leu Arg Val Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gly His Ser Thr Tyr Gly Ala Glu Cys Phe Pro Ala Cys Asn Pro 
            20                  25                  30          


Gln Asn Gly Phe Cys Glu Asp Asp Asn Val Cys Arg Cys Gln Pro Gly 
        35                  40                  45              


Trp Gln Gly Pro Leu Cys Asp Gln Cys Val Thr Ser Pro Gly Cys Leu 
    50                  55                  60                  


His Gly Leu Cys Gly Glu Pro Gly Gln Cys Ile Cys Thr Asp Gly Trp 
65                  70                  75                  80  


Asp Gly Glu Leu Cys Asp Arg Asp Val Arg Ala Cys Ser Ser Ala Pro 
                85                  90                  95      


Cys Ala Asn Asn Gly Thr Cys Val Ser Leu Asp Asp Gly Leu Tyr Glu 
            100                 105                 110         


Cys Ser Cys Ala Pro Gly Tyr Ser Gly Lys Asp Cys Gln Lys Lys Asp 
        115                 120                 125             


Gly Pro Cys Val Ile Asn Gly Ser Pro Cys Gln His Gly Gly Thr Cys 
    130                 135                 140                 


Val Asp Asp Glu Gly Arg Ala Ser His Ala Ser Cys Leu Cys Pro Pro 
145                 150                 155                 160 


Gly Phe Ser Gly Asn Phe Cys Glu Ile Val Ala Asn Ser Cys Thr Pro 
                165                 170                 175     


Asn Pro Cys Glu Asn Asp Gly Val Cys Thr Asp Ile Gly Gly Asp Phe 
            180                 185                 190         


Arg Cys Arg Cys Pro Ala Gly Phe Ile Asp Lys Thr Cys Ser Arg Pro 
        195                 200                 205             


Val Thr Asn Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Thr Cys Leu 
    210                 215                 220                 


Gln His Thr Gln Val Ser Tyr Glu Cys Leu Cys Lys Pro Glu Phe Thr 
225                 230                 235                 240 


Gly Leu Thr Cys Val Lys Lys Arg Ala Leu Ser Pro Gln Gln Val Thr 
                245                 250                 255     


Arg Leu Pro Ser Gly Tyr Gly Leu Ala Tyr Arg Leu Thr Pro Gly Val 
            260                 265                 270         


His Glu Leu Pro Val Gln Gln Pro Glu His Arg Ile Leu Lys Val Ser 
        275                 280                 285             


Met Lys Glu Leu Asn Lys Lys Thr Pro Leu Leu Thr Glu Gly Gln Ala 
    290                 295                 300                 


Ile Cys Phe Thr Ile Leu Gly Val Leu Thr Ser Leu Val Val Leu Gly 
305                 310                 315                 320 


Thr Val Gly Ile Val Phe Leu Asn Lys Cys Glu Thr Trp Val Ser Asn 
                325                 330                 335     


Leu Arg Tyr Asn His Met Leu Arg Lys Lys Lys Asn Leu Leu Leu Gln 
            340                 345                 350         


Tyr Asn Ser Gly Glu Asp Leu Ala Val Asn Ile Ile Phe Pro Glu Lys 
        355                 360                 365             


Ile Asp Met Thr Thr Phe Ser Lys Glu Ala Gly Asp Glu Glu Ile 
    370                 375                 380             


<210>  3204
<211>  1725
<212>  DNA
<213>  Homosapiens

<400>  3204
ttgagtgagc ttggctatcc tctttagctc ttctttcgaa cctttggccg aaggctccaa     60

ccctcccaaa ggcagaaggg agcttaattt gtcctgaaat ggatgggaca agtgtgcagg    120

cactaggtgg gatgggagct ttatctcagt ttgggaggag agggaactca gggccagggc    180

cagcgattgt acagtcccac tcagagggcg gagtggctgg aggctgaccc ttctcccagg    240

gagcaggcgc tggatggacc ctgacactgg ggagaatgaa aggaaaattg tatcatgcct    300

attgtgtgcc aggcagagct agcagttccc ctttcatctg ggcaatgtcc cgggcgggtg    360

atgtcagttc ctcattgtgc agacaaggaa actgagacct ggggcccatc ccatccacga    420

tcagggccca ggcagctccg actcaatgtt cagtgctctc tgcaggcgtc cgggcacttg    480

ccatgcagag cagtgaccaa ggatcacaga tgcagtgggc cgggggggga tggcagaaaa    540

caaagggtta gggtacccgg atgccaggtt ctcagtgctg gtgtcctcac aactggctat    600

ccctatgccc ctgctgtcct cagtgggtgg acactggacc tggactgacc cctgggacag    660

gaggattcaa ggtgtcttgt tctcttttga tttcttttat cttttctctg ccaggaaaga    720

tactgatctc tgttcttggt taagttccaa gaaccatcta agtttcgtgc ccctcagctg    780

taaaagggaa gtacatttca tttgtttatt ctgtaaaact ctcggtgtgt gccatggcca    840

tgcactgatg atgagcacat gtgtgcggcc cctgcccccg tggagcgcat gcatggtcct    900

ccagccagag accgcgctgg gagaaatcag gggttcactc ctggtcggag gtgagcatct    960

gcctctgcat gcaggaaggc atctcatgaa accccaaagg cctggcagcc cctgcacatg   1020

gaaggagtca ctctcctcca tgtggggtga gccacgctgg ccttgtggca ttcacgtgtt   1080

ccctccacct gcttctccag cgtgaagggg acctcaatgt cctctgatga ccttcttgaa   1140

gagagacatt tccttccttc attggaggct ttagacggag ccagtgacag ctcagctctg   1200

gctgtttccc atctgtgaaa tgggaagagg gaggatggca cgagtccctt gccctcacca   1260

aactggccgc tagagagagg aaagatgttt ccattctgat ccccactcac ctccacccca   1320

tccttccagg cttctgatcc tcattgtaat tttggagcta tttggtgata ttgtctttgt   1380

ccttggatcc gaggcttctc ctaccaactc attgtttttt caacgtgaca aaataaaagc   1440

cctgagctgg gcgcggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcagg   1500

tggatgacga ggtcaggagt tcaagaccag cctgaccaac atggtgaaac cccgtctcta   1560

ctaaaaatac aaaaaattag ctgggcatgg tggcatgcac ctgtaatccc agctactcag   1620

gaggctgagg caggagaatc gcttgaaccc gggagccgga ggttgcagtg agtcgagatc   1680

atgccactgc actccagcct gggcaacaag agtgagactc catct                   1725


<210>  3205
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  3205

Met Ala Glu Asn Lys Gly Leu Gly Tyr Pro Asp Ala Arg Phe Ser Val 
1               5                   10                  15      


Leu Val Ser Ser Gln Leu Ala Ile Pro Met Pro Leu Leu Ser Ser Val 
            20                  25                  30          


Gly Gly His Trp Thr Trp Thr Asp Pro Trp Asp Arg Arg Ile Gln Gly 
        35                  40                  45              


Val Leu Phe Ser Phe Asp Phe Phe Tyr Leu Phe Ser Ala Arg Lys Asp 
    50                  55                  60                  


Thr Asp Leu Cys Ser Trp Leu Ser Ser Lys Asn His Leu Ser Phe Val 
65                  70                  75                  80  


Pro Leu Ser Cys Lys Arg Glu Val His Phe Ile Cys Leu Phe Cys Lys 
                85                  90                  95      


Thr Leu Gly Val Cys His Gly His Ala Leu Met Met Ser Thr Cys Val 
            100                 105                 110         


Arg Pro Leu Pro Pro Trp Ser Ala Cys Met Val Leu Gln Pro Glu Thr 
        115                 120                 125             


Ala Leu Gly Glu Ile Arg Gly Ser Leu Leu Val Gly Gly Glu His Leu 
    130                 135                 140                 


Pro Leu His Ala Gly Arg His Leu Met Lys Pro Gln Arg Pro Gly Ser 
145                 150                 155                 160 


Pro Cys Thr Trp Lys Glu Ser Leu Ser Ser Met Trp Gly Glu Pro Arg 
                165                 170                 175     


Trp Pro Cys Gly Ile His Val Phe Pro Pro Pro Ala Ser Pro Ala 
            180                 185                 190     


<210>  3206
<211>  5811
<212>  DNA
<213>  Homosapiens

<400>  3206
ctcctcccct ccccctccgc cctcctccgc tccgggccag cgcggcggcg gcggcggcgg     60

cggcagcagc aggagcagcc ccggctgcgg gtcgcgacgg cggcggggcg ccccctcccc    120

cgtgccgggg cgcggcggag ggatgtgggg ccttgcggga ggaaggcttt tcggcatctt    180

ctcggccccg gtgctggtgg ctgtggtgtg ctgcgcccag agtgtgaacg atcccgggaa    240

catgtccttt gtgaaggaga cggtggacaa gctgttgaaa ggctacgaca ttcgcctaag    300

acccgacttc gggggtcccc cggtctgcgt ggggatgaac atcgacatcg ccagcatcga    360

catggtttcc gaagtcaaca tggattatac cttaaccatg tattttcaac aatattggag    420

agataaaagg ctcgcctatt ctgggatccc tctcaacctc acgcttgaca atcgagtggc    480

tgaccagcta tgggtgcccg acacatattt cttaaatgac aaaaagtcat ttgtgcatgg    540

agtgacagtg aaaaaccgca tgatccgtct tcaccctgat gggacagtgc tgtatgggct    600

cagaatcacc acgacagcag catgcatgat ggacctcagg agataccccc tggacgagca    660

gaactgcact ctggaaattg aaagctatgg ctacaccacg gatgacattg agttttactg    720

gcgaggcggg gacaaggctg ttaccggagt ggaaaggatt gagctcccgc agttctccat    780

cgtggagcac cgtctggtct cgaggaatgt tgtcttcgcc acaggtgcct atcctcgact    840

gtcactgagc tttcggttga agaggaacat tggatacttc attcttcaga cttatatgcc    900

ctctatactg ataacgattc tgtcgtgggt gtccttctgg atcaattatg atgcatctgc    960

tgctagagtt gccctcggga tcacaactgt gctgacaatg acaaccatca acacccacct   1020

tcgggagacc ttgcccaaaa tcccctatgt caaagccatt gacatgtacc ttatgggctg   1080

cttcgtcttt gtgttcctgg cccttctgga gtatgccttt gtcaactaca ttttctttgg   1140

aagaggccct caaaggcaga agaagcttgc agaaaagaca gccaaggcaa agaatgaccg   1200

ttcaaagagc gaaagcaacc gggtggatgc tcatggaaat attctgttga catcgctgga   1260

agttcacaat gaaatgaatg aggtctcagg cggcattggc gataccagga attcagcaat   1320

atcctttgac aactcaggaa tccagtacag gaaacagagc atgcctcgag aagggcatgg   1380

gcgattcctg ggggacagaa gcctcccgca caagaagacc catctacgga ggaggtcttc   1440

acagctcaaa attaaaatac ctgatctaac cgatgtgaat gccatagaca gatggtccag   1500

gatcgtgttt ccattcactt tttctctttt caacttagtt tactggctgt actatgttaa   1560

ctgagtgact gtacttgatt tttcaaagac ttcatttaac actgagtgaa atattactct   1620

gcctgtcaag tttttatacc tgtacacaca cagacacaca agcagacaca cacatatata   1680

catacgcaat tgtatatata tgtgaacttt ctcagcatat atataaaata cacgtgtata   1740

tgaggatgta tgtgtatatg tttatacaca caggagtcag tgcccatgtg tatggaagac   1800

aaatacacat acatatatac attttgcagc tatggacaat ttaccacagg atgcatatta   1860

aagaaagtca tagttttttt cttttttaat tgaaagggac aagtatcatc taaatattat   1920

gccttgagaa tgagggcgtg aaacacaata tcatccccaa atgtgtcttg tattatcata   1980

agttagatgt tttagtttaa aaatcagaaa gacattctta gttaatcttt gaaaactcat   2040

acagtggtat tgctagttta aaatgagtca cttacttcat atcctctcgt tcagtttagt   2100

aagcaaaggc ttcttggctt ctctggtgat ggggtttgtt ttcatcgggc atacgttttc   2160

tgcaatggtt tagtggctgg ggtgagccac tggcagtgtg cttacctgtt gtctgaaaca   2220

tagatagatc ccacgttgat gtctgaacga ccgtcttttg aaaactcatc gggagtgaat   2280

ggcatctcgt tgtaagtact ctaatataca gtgtgtagtt tgtttctgtt gttcacttgg   2340

agtggatcca gcttcactgt catgtgcgaa cacagtgaca cgtttggcca gtgacatttc   2400

aatcactgaa aatgtgctct acatctcgta tggatttcta ggcctgatat ccaacagaaa   2460

gcatagacgt ctcaggttat tcgttactct aaggtaaaac catctaggat gattttcccc   2520

cttgcagtta tgttatcatt cttataacat tgtatgttaa tagaaaatat atttgcataa   2580

tatgcatata tatgtatatt taccaagatt ttgtttctta cgcttgctat catggcagca   2640

tgcgatgtca tattttcctt tatgtgatgt aactactttc tgttatctag aaattaagat   2700

tgaagctaaa acacttctac tgttcaattt cagaaactaa gaatcatcct catgccttta   2760

tttctgtatc tgacatattt cataagcaca tccaactact cctagactga ctaggattct   2820

gcaggaacat gacccgtaca caccacgcgt cacccaacga cccatgaccg ttctctgagg   2880

caaaggaggg caacctgaca gcaaacacag tcactgttgg ttccttctga tccacagcct   2940

catcagtatt tggacttttt aaagctcgta gaaacaagac aaggtgcacc ggtttcatag   3000

acgcaacctt aacttactat ttagatgaga tctttctaaa gaaaaaaaaa agagatgata   3060

tattttttgt aaacaatatt tctatcacag gcatccataa actgaaatga ctacagttgt   3120

gcaaacaggt gtcacagtga agttgagcat ttggagaaaa aaataaaaag caaaatttgc   3180

aggaagaact gctaaattaa tactttatcc caaaatgcca cgtatgcctc accctctctg   3240

ttctatccaa aaccaaggac cagagtgctc caatggtagg ccccagttgt ctcgatgtag   3300

gtagaggcac caccctcccc gaggatgcgt gtggtgtgga ctatccccat gagctgacca   3360

ctacttgatt tttctttggt ggccgtaaca acctttaatt tgtgggcatc tgcaacagtt   3420

caaaacccac catcagataa aacataatcc acaaaatctc acgctagagg caattaccta   3480

cttttagacc cttttccctc tttcattcct atctttttcc tcctaatcgc tgctctctgg   3540

ttttattttc atctggagac tagccaggga tttctttggc tttggctttt ctctgaccat   3600

tttttccatg ggtaacaatg ggggatccta aaagttaaac agattgggaa aaaccttgtt   3660

aagtggcctt atcattatta tcatgttaaa gaaaaaaaat acatttgcaa agaccttatc   3720

cctttcaata cttcaggtat ctttttctgt atccagtaat taaaggtgtg aggtccacat   3780

gcagaagagg gaccccaaaa tgtaaatgga tgtggacaaa aacagtcaat ggtctattta   3840

agtgtataat ttatactatt cagaactgtg acattaattc tttctgggag aaaagtgatt   3900

taaaactttt ttgatgcata gttgaggtac ccaaatatca aaggcagaga ccccatgggg   3960

ctccaaagag ctgcagtctc cttcccaagg ttttctggat ataaatttgc atggtatagt   4020

cataatagct tttgagcttt ttatatgcat ttggcaccaa gactgggatc cacaactttg   4080

tagacactgc gatgaagtta acatattagc tatactataa atagtgtttg taactacaca   4140

cacacacaca cacacacaca caaatacata catatattct gtaaaaacaa aaaaaaactt   4200

tttaagatcc ttgggtatgt gtttgcttta ctccatttca gaagaaaatt acttttcttc   4260

taacaaaatt attttatagc ttctccattt ttaaaacttg tgagagcatt gagaagagaa   4320

ctctgactgt gttaacagaa gagagttgaa ttggagtctc tgttgtgtta aaatgacctc   4380

tcgttactcc acagtagtta tttgagccag tgactgagtc gcgttgagga attctgaacc   4440

cggacctctg acgttgttgg gaggtggctg ttacccacac ccagacctct tgagtaagga   4500

cagaaacgtt atcattgggg atataatgag atttctttct taacaattga aagtaataaa   4560

gagttaattt tctcagtagt cctgtctttc caaaatgcgc cacaggggct caagatctac   4620

agaagaatct tgttatgaca gtttgttatt acccatattc agatatcctt gagataatgg   4680

aagagccctg ctacataact ccctacagag aaagactgat agacttgagt agtccttaaa   4740

acaagtgtta ttcctgttca ccaaccccgg gactgtggag gggtttcact gtctatacca   4800

tgcgacatcc atttcccctg aatctcaaac gaactagaaa gtatgtcatg ataatatttc   4860

cattagattt ggaagctacc tgtacatctg caatattgtg tttttaacgc cagcacccag   4920

aactttgaca tgttcagtca ctccctgaaa ggcacttctc tcttgtccaa acacagcgtt   4980

gacattttta ctgaggagat catctcaaag gtgatgccaa acgagtctgg ggctggtttt   5040

aaggggacag gcacattgca gttgtaggtg ttcattttca gcatctagta gataatccat   5100

tggtgtttgt cccaccattg gtgtattcta acaagaatgt gtccaacttt gaatctcctg   5160

gcttgaaagt ataaaccatc acttaattct tattttaact ctccacctga aaaccagttc   5220

atatttctgg ccattttatg taagcaaaac tgaacaattg gtgaaacatt ttgttactct   5280

tggaattgac tctggctgtc agtgtgagcc attagagtaa catcgaatct tggggcaaag   5340

aactgcccag gtgaattaaa tttttccagg acactagcta gtgtgccttg gattgattac   5400

ctcttctact gcattgaaag gcgccatgtt ttcctgaaat actaaattcc caacacctgg   5460

gtaaacaatg accttccaga gagtggctcc cgtatgcctc tccctaggac caaccccatg   5520

aacatgtttt gtcacgtttg tctcatgttt ctacttcaca agtcagtgag tgtgtttaag   5580

gtaagtacag gattattcta gtaggaatag gcgattgctg tcataatcaa ttctcatgtt   5640

gatttcattt tattgtaaag ataaatttaa acccagtttt gcttaagcac attgatgtaa   5700

ttttttggta ttatttgaca tgaaaaaaca gcaaaattga gtgatagata caatatgaaa   5760

cttgttgatg aatgaattca aatttattaa aaaaggagta actgacctaa a            5811


<210>  3207
<211>  473
<212>  PRT
<213>  Homosapiens

<400>  3207

Met Trp Gly Leu Ala Gly Gly Arg Leu Phe Gly Ile Phe Ser Ala Pro 
1               5                   10                  15      


Val Leu Val Ala Val Val Cys Cys Ala Gln Ser Val Asn Asp Pro Gly 
            20                  25                  30          


Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
        35                  40                  45              


Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
    50                  55                  60                  


Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                85                  90                  95      


Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                 105                 110         


Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                 120                 125             


Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                 135                 140                 


Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                 170                 175     


Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                 185                 190         


Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
        195                 200                 205             


Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
    210                 215                 220                 


Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                 230                 235                 240 


Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu 
                245                 250                 255     


Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
            260                 265                 270         


Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
        275                 280                 285             


Ile Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
    290                 295                 300                 


Ala Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro 
                325                 330                 335     


Gln Arg Gln Lys Lys Leu Ala Glu Lys Thr Ala Lys Ala Lys Asn Asp 
            340                 345                 350         


Arg Ser Lys Ser Glu Ser Asn Arg Val Asp Ala His Gly Asn Ile Leu 
        355                 360                 365             


Leu Thr Ser Leu Glu Val His Asn Glu Met Asn Glu Val Ser Gly Gly 
    370                 375                 380                 


Ile Gly Asp Thr Arg Asn Ser Ala Ile Ser Phe Asp Asn Ser Gly Ile 
385                 390                 395                 400 


Gln Tyr Arg Lys Gln Ser Met Pro Arg Glu Gly His Gly Arg Phe Leu 
                405                 410                 415     


Gly Asp Arg Ser Leu Pro His Lys Lys Thr His Leu Arg Arg Arg Ser 
            420                 425                 430         


Ser Gln Leu Lys Ile Lys Ile Pro Asp Leu Thr Asp Val Asn Ala Ile 
        435                 440                 445             


Asp Arg Trp Ser Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn 
    450                 455                 460                 


Leu Val Tyr Trp Leu Tyr Tyr Val Asn 
465                 470             


<210>  3208
<211>  5725
<212>  DNA
<213>  Homosapiens

<400>  3208
ctcggagagt aggggggaga gcggatccca gcaggttagg ccggaggaac agcgccatgt     60

gctccgggct cctggagctc ctgctgccca tctggctctc ctggaccctg gggacccgag    120

gctctgagcc ccgcagtgtg aacgatcccg ggaacatgtc ctttgtgaag gagacggtgg    180

acaagctgtt gaaaggctac gacattcgcc taagacccga cttcgggggt cccccggtct    240

gcgtggggat gaacatcgac atcgccagca tcgacatggt ttccgaagtc aacatggatt    300

ataccttaac catgtatttt caacaatatt ggagagataa aaggctcgcc tattctggga    360

tccctctcaa cctcacgctt gacaatcgag tggctgacca gctatgggtg cccgacacat    420

atttcttaaa tgacaaaaag tcatttgtgc atggagtgac agtgaaaaac cgcatgatcc    480

gtcttcaccc tgatgggaca gtgctgtatg ggctcagaat caccacgaca gcagcatgca    540

tgatggacct caggagatac cccctggacg agcagaactg cactctggaa attgaaagct    600

atggctacac cacggatgac attgagtttt actggcgagg cggggacaag gctgttaccg    660

gagtggaaag gattgagctc ccgcagttct ccatcgtgga gcaccgtctg gtctcgagga    720

atgttgtctt cgccacaggt gcctatcctc gactgtcact gagctttcgg ttgaagagga    780

acattggata cttcattctt cagacttata tgccctctat actgataacg attctgtcgt    840

gggtgtcctt ctggatcaat tatgatgcat ctgctgctag agttgccctc gggatcacaa    900

ctgtgctgac aatgacaacc atcaacaccc accttcggga gaccttgccc aaaatcccct    960

atgtcaaagc cattgacatg taccttatgg gctgcttcgt ctttgtgttc ctggcccttc   1020

tggagtatgc ctttgtcaac tacattttct ttggaagagg ccctcaaagg cagaagaagc   1080

ttgcagaaaa gacagccaag gcaaagaatg accgttcaaa gagcgaaagc aaccgggtgg   1140

atgctcatgg aaatattctg ttgacatcgc tggaagttca caatgaaatg aatgaggtct   1200

caggcggcat tggcgatacc aggaattcag caatatcctt tgacaactca ggaatccagt   1260

acaggaaaca gagcatgcct cgagaagggc atgggcgatt cctgggggac agaagcctcc   1320

cgcacaagaa gacccatcta cggaggaggt cttcacagct caaaattaaa atacctgatc   1380

taaccgatgt gaatgccata gacagatggt ccaggatcgt gtttccattc actttttctc   1440

ttttcaactt agtttactgg ctgtactatg ttaactgagt gactgtactt gatttttcaa   1500

agacttcatt taacactgag tgaaatatta ctctgcctgt caagttttta tacctgtaca   1560

cacacagaca cacaagcaga cacacacata tatacatacg caattgtata tatatgtgaa   1620

ctttctcagc atatatataa aatacacgtg tatatgagga tgtatgtgta tatgtttata   1680

cacacaggag tcagtgccca tgtgtatgga agacaaatac acatacatat atacattttg   1740

cagctatgga caatttacca caggatgcat attaaagaaa gtcatagttt ttttcttttt   1800

taattgaaag ggacaagtat catctaaata ttatgccttg agaatgaggg cgtgaaacac   1860

aatatcatcc ccaaatgtgt cttgtattat cataagttag atgttttagt ttaaaaatca   1920

gaaagacatt cttagttaat ctttgaaaac tcatacagtg gtattgctag tttaaaatga   1980

gtcacttact tcatatcctc tcgttcagtt tagtaagcaa aggcttcttg gcttctctgg   2040

tgatggggtt tgttttcatc gggcatacgt tttctgcaat ggtttagtgg ctggggtgag   2100

ccactggcag tgtgcttacc tgttgtctga aacatagata gatcccacgt tgatgtctga   2160

acgaccgtct tttgaaaact catcgggagt gaatggcatc tcgttgtaag tactctaata   2220

tacagtgtgt agtttgtttc tgttgttcac ttggagtgga tccagcttca ctgtcatgtg   2280

cgaacacagt gacacgtttg gccagtgaca tttcaatcac tgaaaatgtg ctctacatct   2340

cgtatggatt tctaggcctg atatccaaca gaaagcatag acgtctcagg ttattcgtta   2400

ctctaaggta aaaccatcta ggatgatttt cccccttgca gttatgttat cattcttata   2460

acattgtatg ttaatagaaa atatatttgc ataatatgca tatatatgta tatttaccaa   2520

gattttgttt cttacgcttg ctatcatggc agcatgcgat gtcatatttt cctttatgtg   2580

atgtaactac tttctgttat ctagaaatta agattgaagc taaaacactt ctactgttca   2640

atttcagaaa ctaagaatca tcctcatgcc tttatttctg tatctgacat atttcataag   2700

cacatccaac tactcctaga ctgactagga ttctgcagga acatgacccg tacacaccac   2760

gcgtcaccca acgacccatg accgttctct gaggcaaagg agggcaacct gacagcaaac   2820

acagtcactg ttggttcctt ctgatccaca gcctcatcag tatttggact ttttaaagct   2880

cgtagaaaca agacaaggtg caccggtttc atagacgcaa ccttaactta ctatttagat   2940

gagatctttc taaagaaaaa aaaaagagat gatatatttt ttgtaaacaa tatttctatc   3000

acaggcatcc ataaactgaa atgactacag ttgtgcaaac aggtgtcaca gtgaagttga   3060

gcatttggag aaaaaaataa aaagcaaaat ttgcaggaag aactgctaaa ttaatacttt   3120

atcccaaaat gccacgtatg cctcaccctc tctgttctat ccaaaaccaa ggaccagagt   3180

gctccaatgg taggccccag ttgtctcgat gtaggtagag gcaccaccct ccccgaggat   3240

gcgtgtggtg tggactatcc ccatgagctg accactactt gatttttctt tggtggccgt   3300

aacaaccttt aatttgtggg catctgcaac agttcaaaac ccaccatcag ataaaacata   3360

atccacaaaa tctcacgcta gaggcaatta cctactttta gacccttttc cctctttcat   3420

tcctatcttt ttcctcctaa tcgctgctct ctggttttat tttcatctgg agactagcca   3480

gggatttctt tggctttggc ttttctctga ccattttttc catgggtaac aatgggggat   3540

cctaaaagtt aaacagattg ggaaaaacct tgttaagtgg ccttatcatt attatcatgt   3600

taaagaaaaa aaatacattt gcaaagacct tatccctttc aatacttcag gtatcttttt   3660

ctgtatccag taattaaagg tgtgaggtcc acatgcagaa gagggacccc aaaatgtaaa   3720

tggatgtgga caaaaacagt caatggtcta tttaagtgta taatttatac tattcagaac   3780

tgtgacatta attctttctg ggagaaaagt gatttaaaac ttttttgatg catagttgag   3840

gtacccaaat atcaaaggca gagaccccat ggggctccaa agagctgcag tctccttccc   3900

aaggttttct ggatataaat ttgcatggta tagtcataat agcttttgag ctttttatat   3960

gcatttggca ccaagactgg gatccacaac tttgtagaca ctgcgatgaa gttaacatat   4020

tagctatact ataaatagtg tttgtaacta cacacacaca cacacacaca cacacaaata   4080

catacatata ttctgtaaaa acaaaaaaaa actttttaag atccttgggt atgtgtttgc   4140

tttactccat ttcagaagaa aattactttt cttctaacaa aattatttta tagcttctcc   4200

atttttaaaa cttgtgagag cattgagaag agaactctga ctgtgttaac agaagagagt   4260

tgaattggag tctctgttgt gttaaaatga cctctcgtta ctccacagta gttatttgag   4320

ccagtgactg agtcgcgttg aggaattctg aacccggacc tctgacgttg ttgggaggtg   4380

gctgttaccc acacccagac ctcttgagta aggacagaaa cgttatcatt ggggatataa   4440

tgagatttct ttcttaacaa ttgaaagtaa taaagagtta attttctcag tagtcctgtc   4500

tttccaaaat gcgccacagg ggctcaagat ctacagaaga atcttgttat gacagtttgt   4560

tattacccat attcagatat ccttgagata atggaagagc cctgctacat aactccctac   4620

agagaaagac tgatagactt gagtagtcct taaaacaagt gttattcctg ttcaccaacc   4680

ccgggactgt ggaggggttt cactgtctat accatgcgac atccatttcc cctgaatctc   4740

aaacgaacta gaaagtatgt catgataata tttccattag atttggaagc tacctgtaca   4800

tctgcaatat tgtgttttta acgccagcac ccagaacttt gacatgttca gtcactccct   4860

gaaaggcact tctctcttgt ccaaacacag cgttgacatt tttactgagg agatcatctc   4920

aaaggtgatg ccaaacgagt ctggggctgg ttttaagggg acaggcacat tgcagttgta   4980

ggtgttcatt ttcagcatct agtagataat ccattggtgt ttgtcccacc attggtgtat   5040

tctaacaaga atgtgtccaa ctttgaatct cctggcttga aagtataaac catcacttaa   5100

ttcttatttt aactctccac ctgaaaacca gttcatattt ctggccattt tatgtaagca   5160

aaactgaaca attggtgaaa cattttgtta ctcttggaat tgactctggc tgtcagtgtg   5220

agccattaga gtaacatcga atcttggggc aaagaactgc ccaggtgaat taaatttttc   5280

caggacacta gctagtgtgc cttggattga ttacctcttc tactgcattg aaaggcgcca   5340

tgttttcctg aaatactaaa ttcccaacac ctgggtaaac aatgaccttc cagagagtgg   5400

ctcccgtatg cctctcccta ggaccaaccc catgaacatg ttttgtcacg tttgtctcat   5460

gtttctactt cacaagtcag tgagtgtgtt taaggtaagt acaggattat tctagtagga   5520

ataggcgatt gctgtcataa tcaattctca tgttgatttc attttattgt aaagataaat   5580

ttaaacccag ttttgcttaa gcacattgat gtaatttttt ggtattattt gacatgaaaa   5640

aacagcaaaa ttgagtgata gatacaatat gaaacttgtt gatgaatgaa ttcaaattta   5700

ttaaaaaagg agtaactgac ctaaa                                         5725


<210>  3209
<211>  473
<212>  PRT
<213>  Homosapiens

<400>  3209

Met Cys Ser Gly Leu Leu Glu Leu Leu Leu Pro Ile Trp Leu Ser Trp 
1               5                   10                  15      


Thr Leu Gly Thr Arg Gly Ser Glu Pro Arg Ser Val Asn Asp Pro Gly 
            20                  25                  30          


Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
        35                  40                  45              


Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
    50                  55                  60                  


Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                85                  90                  95      


Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                 105                 110         


Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                 120                 125             


Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                 135                 140                 


Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                 170                 175     


Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                 185                 190         


Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
        195                 200                 205             


Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
    210                 215                 220                 


Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                 230                 235                 240 


Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu 
                245                 250                 255     


Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
            260                 265                 270         


Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
        275                 280                 285             


Ile Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
    290                 295                 300                 


Ala Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro 
                325                 330                 335     


Gln Arg Gln Lys Lys Leu Ala Glu Lys Thr Ala Lys Ala Lys Asn Asp 
            340                 345                 350         


Arg Ser Lys Ser Glu Ser Asn Arg Val Asp Ala His Gly Asn Ile Leu 
        355                 360                 365             


Leu Thr Ser Leu Glu Val His Asn Glu Met Asn Glu Val Ser Gly Gly 
    370                 375                 380                 


Ile Gly Asp Thr Arg Asn Ser Ala Ile Ser Phe Asp Asn Ser Gly Ile 
385                 390                 395                 400 


Gln Tyr Arg Lys Gln Ser Met Pro Arg Glu Gly His Gly Arg Phe Leu 
                405                 410                 415     


Gly Asp Arg Ser Leu Pro His Lys Lys Thr His Leu Arg Arg Arg Ser 
            420                 425                 430         


Ser Gln Leu Lys Ile Lys Ile Pro Asp Leu Thr Asp Val Asn Ala Ile 
        435                 440                 445             


Asp Arg Trp Ser Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn 
    450                 455                 460                 


Leu Val Tyr Trp Leu Tyr Tyr Val Asn 
465                 470             


<210>  3210
<211>  2352
<212>  DNA
<213>  Homosapiens

<400>  3210
gaagatgctg ttgagggccc tggagaaact tcagcagaac agggcctctc cccttgcagg     60

ccgagccggg gccctgcgcc ctccccctcc gcccagctcg gccaagggcg catttgctga    120

gcgtctggcg gcctctaccg gagcacctct gcagagggcc gatcctccag cccagagacg    180

acatgtggcg ctcgggcgag tgccttgcag agagaggagt agcttgctgg ctttgaacgc    240

gtggcgtggc agatatttca gaaagcttca agaacaagct ggagaaggga agagttattc    300

ctccatattc acctgcttca actactattc ttattgggaa tggacaatgg aatgttctct    360

ggttttatca tgatcaaaaa cctccttctc ttttgtattt ccatgaactt atccagtcac    420

tttggctttt cacagatgcc aaccagttca gtgaaagatg agaccaatga caacatcacg    480

atatttacca ggatcttgga tgggctcttg gatggctacg acaacagact tcggcccggg    540

ctgggagagc gcatcactca ggtgaggacc gacatctacg tcaccagctt cggcccggtg    600

tccgacacgg aaatggagta caccatagac gtgtttttcc gacaaagctg gaaagatgaa    660

aggcttcggt ttaaggggcc catgcagcgc ctccctctca acaacctcct tgccagcaag    720

atctggaccc cagacacgtt cttccacaac gggaagaagt ccatcgctca caacatgacc    780

acgcccaaca agctgctgcg gctggaggac gacggcaccc tgctctacac catgcgcttg    840

accatctctg cagagtgccc catgcagctt gaggacttcc cgatggatgc gcacgcttgc    900

cctctgaaat ttggcagcta tgcgtaccct aattctgaag tcgtttacgt ctggaccaac    960

ggctccacca agtcggtggt ggtggcggaa gatggctcca gactgaacca gtaccacctg   1020

atggggcaga cggtgggcac tgagaacatc agcaccagca caggcgaata cacaatcatg   1080

acagctcact tccacctgaa aaggaagatt ggctactttg tcatccagac ctaccttccc   1140

tgcataatga ccgtgatctt atcacaggtg tccttttggc tgaaccggga atcagtccca   1200

gccaggacag tttttggggt caccacggtg ctgaccatga cgaccctcag catcagcgcc   1260

aggaactctc tgcccaaagt ggcctacgcc accgccatgg actggttcat agctgtgtgc   1320

tatgccttcg tcttctcggc gctgatagag tttgccacgg tcaattactt taccaagaga   1380

ggctgggcct gggatggcaa aaaagccttg gaagcagcca agatcaagaa aaagcgtgaa   1440

gtcatactaa ataagtcaac aaacgctttt acaactggga agatgtctca ccccccaaac   1500

attccgaagg aacagacccc agcagggacg tcgaatacaa cctcagtctc agtaaaaccc   1560

tctgaagaga agacttctga aagcaaaaag acttacaaca gtatcagcaa aattgacaaa   1620

atgtcccgaa tcgtattccc agtcttgttc ggcactttca acttagttta ctgggcaacg   1680

tatttgaata gggagccggt gataaaagga gccgcctctc caaaataacc ggccacactc   1740

ccaaactcca agacagccat acttccagcg aaatggtacc aaggagaggt tttgctcaca   1800

gggactctcc atatgtgagc actatctttc aggaaatttt tgcatgttta ataatatgta   1860

caaataatat tgccttgatg tttctatatg taacttcaga tgtttccaag atgtcccatt   1920

gataattcga gcaaacaact ttctggaaaa acaggatacg atgactgaca ctcagatgcc   1980

cagtatcata cgttgatagt ttacaaacaa gatacgtata tttttaactg cttcaagtgt   2040

tacctaacaa tgttttttat acttcaaatg tcatttcata caaattttcc cagtgaataa   2100

atattttagg aaactctcca tgattattag aagaccaact atattgcgag aaacagagat   2160

cataaagagc acgttttcca ttatgaggaa acttggacat ttatgtacaa aatgaattgc   2220

ctttgataat tcttactgtt ctgaaattag gaaagtactt gcatgatctt acacgaagaa   2280

atagaatagg caaactttta tgtaggcaga ttaataacag aaatacatca tatgttagat   2340

acacaaaata tt                                                       2352


<210>  3211
<211>  462
<212>  PRT
<213>  Homosapiens

<400>  3211

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr 
145                 150                 155                 160 


Leu Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Gln 
                165                 170                 175     


Leu Glu Asp Phe Pro Met Asp Ala His Ala Cys Pro Leu Lys Phe Gly 
            180                 185                 190         


Ser Tyr Ala Tyr Pro Asn Ser Glu Val Val Tyr Val Trp Thr Asn Gly 
        195                 200                 205             


Ser Thr Lys Ser Val Val Val Ala Glu Asp Gly Ser Arg Leu Asn Gln 
    210                 215                 220                 


Tyr His Leu Met Gly Gln Thr Val Gly Thr Glu Asn Ile Ser Thr Ser 
225                 230                 235                 240 


Thr Gly Glu Tyr Thr Ile Met Thr Ala His Phe His Leu Lys Arg Lys 
                245                 250                 255     


Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val 
            260                 265                 270         


Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala 
        275                 280                 285             


Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser 
    290                 295                 300                 


Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met 
305                 310                 315                 320 


Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile 
                325                 330                 335     


Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp 
            340                 345                 350         


Gly Lys Lys Ala Leu Glu Ala Ala Lys Ile Lys Lys Lys Arg Glu Val 
        355                 360                 365             


Ile Leu Asn Lys Ser Thr Asn Ala Phe Thr Thr Gly Lys Met Ser His 
    370                 375                 380                 


Pro Pro Asn Ile Pro Lys Glu Gln Thr Pro Ala Gly Thr Ser Asn Thr 
385                 390                 395                 400 


Thr Ser Val Ser Val Lys Pro Ser Glu Glu Lys Thr Ser Glu Ser Lys 
                405                 410                 415     


Lys Thr Tyr Asn Ser Ile Ser Lys Ile Asp Lys Met Ser Arg Ile Val 
            420                 425                 430         


Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr 
        435                 440                 445             


Leu Asn Arg Glu Pro Val Ile Lys Gly Ala Ala Ser Pro Lys 
    450                 455                 460         


<210>  3212
<211>  1536
<212>  DNA
<213>  Homosapiens

<400>  3212
tgaattcgtg agatggcgag ctccacggca ccatggcccc gaagctgctg ctcctcctct     60

gcctgttctc gggcttgcac gcgcggtcca gaaaggtgga agaggatgaa tatgaagatt    120

catcatcaaa ccaaaagtgg gtcttggctc caaaatccca agacaccgac gtgactctta    180

ttctcaacaa gttgctaaga gagtatgata aaaagctgag gccagatatt ggaataaaac    240

cgaccgtaat tgacgttgac atttatgtta acagcattgg tcctgtgtca tcaataaaca    300

tggaatacca aattgacata ttttttgctc agacctggac agatagtcgc cttcgattca    360

acagcacaat gaaaattctt actctgaaca gcaacatggt ggggttaatc tggatcccag    420

acaccatctt ccgcaattct aaaaccgcag aggctcactg gatcaccaca cccaatcagc    480

tcctccggat ttggaatgac gggaaaatcc tttacacttt gaggctcacc atcaatgctg    540

agtgccagct gcagctgcac aacttcccca tggacgaaca ctcctgcccg ctgattttct    600

ccagctatgg ctatcccaaa gaagaaatga tttatagatg gagaaaaaat tcagtggagg    660

cagctgacca gaaatcatgg cggctttatc agtttgactt catgggcctc agaaacacca    720

cagaaatcgt gacaacgtct gcaggtgatt atgttgtcat gactatatat tttgaattga    780

gtagaagaat gggatacttc accattcaga catacattcc ctgtatactg actgtggttt    840

tatcctgggt gtcattttgg atcaaaaaag atgctacgcc agcaagaaca gcattaggca    900

tcaccacggt gctgaccatg accaccctga gcaccatcgc caggaagtcc ttgccacgcg    960

tgtcctacgt gaccgccatg gacctttttg tgactgtgtg cttcctgttt gtcttcgccg   1020

cgctgatgga gtatgccacc ctcaactact attccagctg tagaaaacca accaccacga   1080

aaaagacaac atcgttacta catccagatt cctcaagatg gattcctgag cgaataagcc   1140

tacaagcccc ttccaactat tccctcctgg acatgaggcc accaccacct gcgatgatca   1200

ctttaaacaa ttccgtttac tggcaggaat ttgaagatac ctgtgtctat gagtgtctgg   1260

atggcaaaga ctgtcagagc ttcttctgct gctatgaaga atgtaaatca ggatcctgga   1320

ggaaagggcg tattcacata gacatcttgg agctggactc gtactcccgg gtctttttcc   1380

ccacgtcctt cctgctcttt aacctggtct actgggttgg atacctgtat ctctaagtgt   1440

tgctcagagt gaagagtgaa gagcatttgg tacacacttg accttctgtc gtccccagac   1500

cagtagtgac caatcgggag tagcaaggaa ggacac                             1536


<210>  3213
<211>  467
<212>  PRT
<213>  Homosapiens

<400>  3213

Met Ala Pro Lys Leu Leu Leu Leu Leu Cys Leu Phe Ser Gly Leu His 
1               5                   10                  15      


Ala Arg Ser Arg Lys Val Glu Glu Asp Glu Tyr Glu Asp Ser Ser Ser 
            20                  25                  30          


Asn Gln Lys Trp Val Leu Ala Pro Lys Ser Gln Asp Thr Asp Val Thr 
        35                  40                  45              


Leu Ile Leu Asn Lys Leu Leu Arg Glu Tyr Asp Lys Lys Leu Arg Pro 
    50                  55                  60                  


Asp Ile Gly Ile Lys Pro Thr Val Ile Asp Val Asp Ile Tyr Val Asn 
65                  70                  75                  80  


Ser Ile Gly Pro Val Ser Ser Ile Asn Met Glu Tyr Gln Ile Asp Ile 
                85                  90                  95      


Phe Phe Ala Gln Thr Trp Thr Asp Ser Arg Leu Arg Phe Asn Ser Thr 
            100                 105                 110         


Met Lys Ile Leu Thr Leu Asn Ser Asn Met Val Gly Leu Ile Trp Ile 
        115                 120                 125             


Pro Asp Thr Ile Phe Arg Asn Ser Lys Thr Ala Glu Ala His Trp Ile 
    130                 135                 140                 


Thr Thr Pro Asn Gln Leu Leu Arg Ile Trp Asn Asp Gly Lys Ile Leu 
145                 150                 155                 160 


Tyr Thr Leu Arg Leu Thr Ile Asn Ala Glu Cys Gln Leu Gln Leu His 
                165                 170                 175     


Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Ile Phe Ser Ser Tyr 
            180                 185                 190         


Gly Tyr Pro Lys Glu Glu Met Ile Tyr Arg Trp Arg Lys Asn Ser Val 
        195                 200                 205             


Glu Ala Ala Asp Gln Lys Ser Trp Arg Leu Tyr Gln Phe Asp Phe Met 
    210                 215                 220                 


Gly Leu Arg Asn Thr Thr Glu Ile Val Thr Thr Ser Ala Gly Asp Tyr 
225                 230                 235                 240 


Val Val Met Thr Ile Tyr Phe Glu Leu Ser Arg Arg Met Gly Tyr Phe 
                245                 250                 255     


Thr Ile Gln Thr Tyr Ile Pro Cys Ile Leu Thr Val Val Leu Ser Trp 
            260                 265                 270         


Val Ser Phe Trp Ile Lys Lys Asp Ala Thr Pro Ala Arg Thr Ala Leu 
        275                 280                 285             


Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr Ile Ala Arg 
    290                 295                 300                 


Lys Ser Leu Pro Arg Val Ser Tyr Val Thr Ala Met Asp Leu Phe Val 
305                 310                 315                 320 


Thr Val Cys Phe Leu Phe Val Phe Ala Ala Leu Met Glu Tyr Ala Thr 
                325                 330                 335     


Leu Asn Tyr Tyr Ser Ser Cys Arg Lys Pro Thr Thr Thr Lys Lys Thr 
            340                 345                 350         


Thr Ser Leu Leu His Pro Asp Ser Ser Arg Trp Ile Pro Glu Arg Ile 
        355                 360                 365             


Ser Leu Gln Ala Pro Ser Asn Tyr Ser Leu Leu Asp Met Arg Pro Pro 
    370                 375                 380                 


Pro Pro Ala Met Ile Thr Leu Asn Asn Ser Val Tyr Trp Gln Glu Phe 
385                 390                 395                 400 


Glu Asp Thr Cys Val Tyr Glu Cys Leu Asp Gly Lys Asp Cys Gln Ser 
                405                 410                 415     


Phe Phe Cys Cys Tyr Glu Glu Cys Lys Ser Gly Ser Trp Arg Lys Gly 
            420                 425                 430         


Arg Ile His Ile Asp Ile Leu Glu Leu Asp Ser Tyr Ser Arg Val Phe 
        435                 440                 445             


Phe Pro Thr Ser Phe Leu Leu Phe Asn Leu Val Tyr Trp Val Gly Tyr 
    450                 455                 460                 


Leu Tyr Leu 
465         


<210>  3214
<211>  2171
<212>  DNA
<213>  Homosapiens

<400>  3214
ggccgcaggc gcaggcccgg gcgacagccg agacgtggag cgcgccggct cgctgcagct     60

ccgggactca acatgcgctg ctcgccggga ggcgtctggc tggcgctggc cgcgtcgctc    120

ctgcacgtgt ccctgcaagg cgagttccag aggaagcttt acaaggagct ggtcaagaac    180

tacaatccct tggagaggcc cgtggccaat gactcgcaac cactcaccgt ctacttctcc    240

ctgagcctcc tgcagatcat ggacgtggat gagaagaacc aagttttaac caccaacatt    300

tggctgcaaa tgtcttggac agatcactat ttacagtgga atgtgtcaga atatccaggg    360

gtgaagactg ttcgtttccc agatggccag atttggaaac cagacattct tctctataac    420

agtgctgatg agcgctttga cgccacattc cacactaacg tgttggtgaa ttcttctggg    480

cattgccagt acctgcctcc aggcatattc aagagttcct gctacatcga tgtacgctgg    540

tttccctttg atgtgcagca ctgcaaactg aagtttgggt cctggtctta cggaggctgg    600

tccttggatc tgcagatgca ggaggcagat atcagtggct atatccccaa tggagaatgg    660

gacctagtgg gaatccccgg caagaggagt gaaaggttct atgagtgctg caaagagccc    720

taccccgatg tcaccttcac agtgaccatg cgccgcagga cgctctacta tggcctcaac    780

ctgctgatcc cctgtgtgct catctccgcc ctcgccctgc tggtgttcct gcttcctgca    840

gattccgggg agaagatttc cctggggata acagtcttac tctctcttac cgtcttcatg    900

ctgctcgtgg ctgagatcat gcccgcaaca tccgattcgg taccattgat agcccagtac    960

ttcgccagca ccatgatcat cgtgggcctc tcggtggtgg tgacagtgat cgtgctgcag   1020

taccaccacc acgaccccga cgggggcaag atgcccaagt ggaccagagt catccttctg   1080

aactggtgcg cgtggttcct gcgaatgaag aggcccgggg aggacaaggt gcgcccggcc   1140

tgccagcaca agcagcggcg ctgcagcctg gccagtgtgg agatgagcgc cgtggcgccg   1200

ccgcccgcca gcaacgggaa cctgctgtac atcggcttcc gcggcctgga cggcgtgcac   1260

tgtgtcccga cccccgactc tggggtagtg tgtggccgca tggcctgctc ccccacgcac   1320

gatgagcacc tcctgcacgg cgggcaaccc cccgaggggg acccggactt ggccaagatc   1380

ctggaggagg tccgctacat tgccaaccgc ttccgctgcc aggacgaaag cgaggcggtc   1440

tgcagcgagt ggaagttcgc cgcctgtgtg gtggaccgcc tgtgcctcat ggccttctcg   1500

gtcttcacca tcatctgcac catcggcatc ctgatgtcgg ctcccaactt cgtggaggcc   1560

gtgtccaaag actttgcgta accacgcctg gttctgtaca tgtggaaaac tcacagatgg   1620

gcaaggcctt tggcttggcg agatttgggg gtgctaatcc aggacagcat tacacgccac   1680

aactccagtg ttcccttctg gctgtcagtc gtgttgctta cggtttcttt gttactttag   1740

gtagtagaat ctcagcactt tgtttcatat tctcagatgg gctgatagat atccttggca   1800

catccgtacc atcggtcagc agggccactg agtagtcatt ttgcccatta gcccactgcc   1860

tggaaagccc ttcggagagc tccccatggc tcctcaccac cgagacagtt ggttttgcat   1920

gtctgcatga aggtctacct gaaaattcaa catttgcttt ttgcttgtgt acaaacccag   1980

attgaagcta aaataaacca gactcactaa atcctttcca ataattgact ggtggaagga   2040

aaacaaaaaa caaaaactaa aaacctctta gcttttctgc aattcaactt tttattttta   2100

tttttatttc tatcaaagac ggtagagaga aacagcttga tgctgtttct acattaaaaa   2160

aaaaaaaaaa a                                                        2171


<210>  3215
<211>  502
<212>  PRT
<213>  Homosapiens

<400>  3215

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Thr Leu Tyr Tyr Gly Leu Asn Leu Leu Ile Pro 
225                 230                 235                 240 


Cys Val Leu Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro Ala 
                245                 250                 255     


Asp Ser Gly Glu Lys Ile Ser Leu Gly Ile Thr Val Leu Leu Ser Leu 
            260                 265                 270         


Thr Val Phe Met Leu Leu Val Ala Glu Ile Met Pro Ala Thr Ser Asp 
        275                 280                 285             


Ser Val Pro Leu Ile Ala Gln Tyr Phe Ala Ser Thr Met Ile Ile Val 
    290                 295                 300                 


Gly Leu Ser Val Val Val Thr Val Ile Val Leu Gln Tyr His His His 
305                 310                 315                 320 


Asp Pro Asp Gly Gly Lys Met Pro Lys Trp Thr Arg Val Ile Leu Leu 
                325                 330                 335     


Asn Trp Cys Ala Trp Phe Leu Arg Met Lys Arg Pro Gly Glu Asp Lys 
            340                 345                 350         


Val Arg Pro Ala Cys Gln His Lys Gln Arg Arg Cys Ser Leu Ala Ser 
        355                 360                 365             


Val Glu Met Ser Ala Val Ala Pro Pro Pro Ala Ser Asn Gly Asn Leu 
    370                 375                 380                 


Leu Tyr Ile Gly Phe Arg Gly Leu Asp Gly Val His Cys Val Pro Thr 
385                 390                 395                 400 


Pro Asp Ser Gly Val Val Cys Gly Arg Met Ala Cys Ser Pro Thr His 
                405                 410                 415     


Asp Glu His Leu Leu His Gly Gly Gln Pro Pro Glu Gly Asp Pro Asp 
            420                 425                 430         


Leu Ala Lys Ile Leu Glu Glu Val Arg Tyr Ile Ala Asn Arg Phe Arg 
        435                 440                 445             


Cys Gln Asp Glu Ser Glu Ala Val Cys Ser Glu Trp Lys Phe Ala Ala 
    450                 455                 460                 


Cys Val Val Asp Arg Leu Cys Leu Met Ala Phe Ser Val Phe Thr Ile 
465                 470                 475                 480 


Ile Cys Thr Ile Gly Ile Leu Met Ser Ala Pro Asn Phe Val Glu Ala 
                485                 490                 495     


Val Ser Lys Asp Phe Ala 
            500         


<210>  3216
<211>  2330
<212>  DNA
<213>  Homosapiens

<400>  3216
gaattcggca cgagcgacgc ggcccagagg ccaggaacat tccgcgcgtg gaccagccgg     60

gccagggcga tgctgcgggt gcggtgtctg cgcggcggga gccgcggcgc cgaggcggtg    120

cactacatcg gatctcggct tggacgaacc ttgacaggat gggtgcagcg aactttccag    180

agcacccagg cagctacggc ttcctcccgg aactcctgtg cagctgacga caaagccact    240

gagcctctgc ccaaggactg ccctgtctct tcttacaacg aatgggaccc cttagaggaa    300

gtgatagtgg gcagagcaga aaacgcctgt gttccaccgt tcaccatcga ggtgaaggcc    360

aacacatatg aaaagtactg gccattttac cagaagcaag gagggcatta ttttcccaaa    420

gatcatttga aaaaggctgt tgctgaaatt gaagaaatgt gcaatatttt aaaaacggaa    480

ggagtgacag taaggaggcc tgaccccatt gactggtcat tgaagtataa aactcctgat    540

tttgagtcta cgggtttata cagtgcaatg cctcgagaca tcctgatagt tgtgggcaat    600

gagattatcg aggctcccat ggcatggcgt tcacgcttct ttgagtaccg agcgtacagg    660

tcaattatca aagactactt ccaccgtggc gccaagtgga caacagctcc taagcccaca    720

atggctgatg agctttataa ccaggattat cccatccact ctgtagaaga cagacacaaa    780

ttggctgctc agggaaaatt tgtgacaact gagtttgagc catgctttga tgctgctgac    840

ttcattcgag ctggaagaga tatttttgca cagagaagcc aggttacaaa ctacctaggc    900

attgaatgga tgcgtaggca tcttgctcca gactacagag tgcatatcat ctcctttaaa    960

gatcccaatc ccatgcatat tgatgctacc ttcaacatca ttggacctgg tattgtgctt   1020

tccaaccctg accgaccatg tcaccagatt gatcttttca agaaagcagg atggactatc   1080

attactcctc caacaccaat catcccagac gatcatccac tctggatgtc atccaaatgg   1140

ctttccatga atgtcttaat gctagatgaa aaacgtgtta tggtggatgc caatgaagtt   1200

ccaattcaaa agatgtttga aaagctgggt atcactacca ttaaagttaa cattcgtaat   1260

gccaattccc tgggaggagg cttccattgc tggacctgcg atgtccggcg ccgaggcacc   1320

ctacagtcct acttggactg aacaggcctg atggagcttg tggctggcct cagatacacc   1380

taagaagctt aggggcaagg ttcattctcc tgctttaaaa agtgcatgaa ctgtagtgct   1440

ttaaacaatc atctccttaa caggggtcgt aagcctggtt tgcttctatt acttttcttt   1500

gacataaaga aaataacttc tgctaggtat tactctctac tcctaaagtt atttactatt   1560

tggcttcaag tataaaattt tggtgaatgt gtaccaagaa aaaattagtc acctgagtaa   1620

cttggccact aataattaac catctacctc tgtttttaat tttctttcca aaaggcagct   1680

tgaaatgttg gtcctaatct taattttttt tcctcttcta tagacttgag aatgtttttc   1740

tctaaatgag agaaagactt agaatgtaca cagatccaaa atagaatcag attatctctt   1800

tttttctaaa ggagagaaag acttagaaca tacacagatc ctaagtagaa ccaggtaatt   1860

gtctcttttt ctaataagga atttgggtaa tttttaattt tttgtttttt aaaaaataac   1920

ctagactatg caaaacatca aagtgaattt tccatgaatg tttttaatat tctcatctca   1980

acattgtgat atatgctact aaaaaccttt tcatatacat cttacctcat ttcaagtgaa   2040

ttattttaat ctttttctct ctttccaaaa atttacagga atgtttagtg taattggatt   2100

tcgctatcag ttcccatcct taagttttga tattcaatat ctgatagata cactgcatct   2160

ttggtcatct aagatttgtt tacaaatgtg caaattattt agagcataga ctttataagc   2220

attaaaaaaa actaatggag gtaaaaccta aatgcgatgt gaaataattt tagtgttgat   2280

actgtatgtg tatttttatt ctaataaact tttgtgttcc agattgaaaa              2330


<210>  3217
<211>  423
<212>  PRT
<213>  Homosapiens

<400>  3217

Met Leu Arg Val Arg Cys Leu Arg Gly Gly Ser Arg Gly Ala Glu Ala 
1               5                   10                  15      


Val His Tyr Ile Gly Ser Arg Leu Gly Arg Thr Leu Thr Gly Trp Val 
            20                  25                  30          


Gln Arg Thr Phe Gln Ser Thr Gln Ala Ala Thr Ala Ser Ser Arg Asn 
        35                  40                  45              


Ser Cys Ala Ala Asp Asp Lys Ala Thr Glu Pro Leu Pro Lys Asp Cys 
    50                  55                  60                  


Pro Val Ser Ser Tyr Asn Glu Trp Asp Pro Leu Glu Glu Val Ile Val 
65                  70                  75                  80  


Gly Arg Ala Glu Asn Ala Cys Val Pro Pro Phe Thr Ile Glu Val Lys 
                85                  90                  95      


Ala Asn Thr Tyr Glu Lys Tyr Trp Pro Phe Tyr Gln Lys Gln Gly Gly 
            100                 105                 110         


His Tyr Phe Pro Lys Asp His Leu Lys Lys Ala Val Ala Glu Ile Glu 
        115                 120                 125             


Glu Met Cys Asn Ile Leu Lys Thr Glu Gly Val Thr Val Arg Arg Pro 
    130                 135                 140                 


Asp Pro Ile Asp Trp Ser Leu Lys Tyr Lys Thr Pro Asp Phe Glu Ser 
145                 150                 155                 160 


Thr Gly Leu Tyr Ser Ala Met Pro Arg Asp Ile Leu Ile Val Val Gly 
                165                 170                 175     


Asn Glu Ile Ile Glu Ala Pro Met Ala Trp Arg Ser Arg Phe Phe Glu 
            180                 185                 190         


Tyr Arg Ala Tyr Arg Ser Ile Ile Lys Asp Tyr Phe His Arg Gly Ala 
        195                 200                 205             


Lys Trp Thr Thr Ala Pro Lys Pro Thr Met Ala Asp Glu Leu Tyr Asn 
    210                 215                 220                 


Gln Asp Tyr Pro Ile His Ser Val Glu Asp Arg His Lys Leu Ala Ala 
225                 230                 235                 240 


Gln Gly Lys Phe Val Thr Thr Glu Phe Glu Pro Cys Phe Asp Ala Ala 
                245                 250                 255     


Asp Phe Ile Arg Ala Gly Arg Asp Ile Phe Ala Gln Arg Ser Gln Val 
            260                 265                 270         


Thr Asn Tyr Leu Gly Ile Glu Trp Met Arg Arg His Leu Ala Pro Asp 
        275                 280                 285             


Tyr Arg Val His Ile Ile Ser Phe Lys Asp Pro Asn Pro Met His Ile 
    290                 295                 300                 


Asp Ala Thr Phe Asn Ile Ile Gly Pro Gly Ile Val Leu Ser Asn Pro 
305                 310                 315                 320 


Asp Arg Pro Cys His Gln Ile Asp Leu Phe Lys Lys Ala Gly Trp Thr 
                325                 330                 335     


Ile Ile Thr Pro Pro Thr Pro Ile Ile Pro Asp Asp His Pro Leu Trp 
            340                 345                 350         


Met Ser Ser Lys Trp Leu Ser Met Asn Val Leu Met Leu Asp Glu Lys 
        355                 360                 365             


Arg Val Met Val Asp Ala Asn Glu Val Pro Ile Gln Lys Met Phe Glu 
    370                 375                 380                 


Lys Leu Gly Ile Thr Thr Ile Lys Val Asn Ile Arg Asn Ala Asn Ser 
385                 390                 395                 400 


Leu Gly Gly Gly Phe His Cys Trp Thr Cys Asp Val Arg Arg Arg Gly 
                405                 410                 415     


Thr Leu Gln Ser Tyr Leu Asp 
            420             


<210>  3218
<211>  2522
<212>  DNA
<213>  Homosapiens

<400>  3218
gtttcctaat ctggtttcgt ctgcttggtt catctgtgtg cgatggctcc ggactcggat     60

cccttccctg aagggccgct cttaaagctg ctacccttag acgctagaga ccggggcacc    120

cagcgctgcc gcctgggccc ggccgccctc cacgccctgg gcgcgcgctt gggctcggca    180

gtgaagatct cgctacccga cggcggctcc tgcctctgca ctgcctggcc tcggcgggac    240

ggagcggacg gctttgtgca gctggacccg ctgtgcgcga gccccggggc ggcggtcggg    300

gcgtcgagat cccggaggag tctcagcctg aatcgcctcc tcctagtgcc ctgtccgccc    360

ctgcggcgcg tcgccgtgtg gccggtgttg cgagagcggg caggcgcgcc cggtgcccgg    420

aatacagccg cggtgctgga ggcggcacag gagctgctga gaaaccgacc gatctccctg    480

ggccacgtgg tggtcgctcc gccaggcgct cctggcctgg tggctgcctt gcacatcgtc    540

ggcgggacgc ccagtcccga tcccgctggg ctggtcaccc ctcgtacccg cgtcagcctt    600

ggcggggagc ctccgtcgga agcccagccg cagcccgagg tgcccctggg aggtctttcg    660

gaggcggccg actcgctgcg ggagctcctc cgcctcccgc tccgctaccc gcgcgccctg    720

accgcgctgg gcttagcggt gcctcgcggg gtgctcctgg cggggccccc cggagtgggc    780

aagacccagc tggtgcaggc cgtggcgcgc gaggcgggcg cggagctgct ggcagtcagc    840

gccccggcgc tgcagggttc ccggcctggg gagaccgagg agaacgtgcg gcgggtcttc    900

cagcgcgccc gggaactggc cagccgcgga cccagcctcc tcttcctgga cgagatggac    960

gccttgtgtc cccagcgggg cagtcgagca cccgagagcc gcgtagtggc ccaggtgttg   1020

acgctgctgg acggcgccag tggggaccgc gaggtcgtgg ttgtgggagc cactaaccgg   1080

ccggacgctc tagacccagc gctgcgtaga cccgggagat ttgaccgaga ggtggtcatt   1140

gggactccca cacttaaaca aagaaaggaa attctgcaag tgattacctc gaagatgccc   1200

atctccagtc atgttgattt gggccttctt gcagaaatga cagttggcta tgttggtgcc   1260

gacctgacag cactctgtag ggaggctgcc atgcatgccc tccttcatag tgagaagaac   1320

caggacaatc ctgtgattga tgaaatagac ttccttgaag cttttaaaaa tattcagccc   1380

tcatcgtttc gaagcgtcat tggattaatg gatatcaagc ctgttgactg ggaggagatt   1440

ggtggccttg aagatgtaaa actgaagtta aaacagagca ttgagtggcc tctgaaattc   1500

ccttgggaat ttgttagaat gggcctgaca caaccaaagg gagttctcct ctatgggccc   1560

cctggatgtg ctaaaaccac tctggtgagg gccctggcca caagctgtca ctgctctttc   1620

gtttcagtga gtggagctga tctgttttca ccgtttgttg gagattcaga aaaagtgttg   1680

tctcagatat ttcgacaagc aagagcaagc actccagcaa ttttgttttt ggatgaaatt   1740

gattcaatct tgggagctcg ctcagccagc aagacaggat gtgatgttca agaacgagtt   1800

ctttctgttc tcctgaatga attagatggt gttggactta agacaataga gagaagagga   1860

agtaaatcaa gtcaacagga gtttcaagaa gtttttaacc gaagtgtcat gattattgca   1920

gcaacaaata gacctgatgt gttagatact gctttgttac gacctggaag attagataag   1980

atcatctata tcccacctcc agatcacaag ggcaggcttt ctattttaaa agtctgtaca   2040

aaaaccatgc caatagggcc tgatgtctcc ttagaaaacc tcgcagcaga aacctgtttt   2100

ttttctggag ctgatcttag aaacctctgc acagaagctg ctttgctggc tctgcaagaa   2160

aatggactag acgcaactac agtgaaacaa gagcactttc taaaatcact taagactgta   2220

aaaccgtcgt taagttgcaa ggacttggct ttatatgaaa acttatttaa gaaagaagga   2280

ttttctaacg tggaaggtat ttaaaaatca ccttaaactc ttgttcagtt cacattaatt   2340

gaaatgtgaa cttgcctgtc gtttgcaact tcacactttt agaatttgtg tttatatttc   2400

ctgtaagtga ataaataaaa caaaacaaaa caaaaaaaac ttgtgcctga taagctaagg   2460

ctcatttatt tttaaaaggc atattaaata aaatactgta atttaggaaa aaaaaaaaaa   2520

aa                                                                  2522


<210>  3219
<211>  753
<212>  PRT
<213>  Homosapiens

<400>  3219

Met Ala Pro Asp Ser Asp Pro Phe Pro Glu Gly Pro Leu Leu Lys Leu 
1               5                   10                  15      


Leu Pro Leu Asp Ala Arg Asp Arg Gly Thr Gln Arg Cys Arg Leu Gly 
            20                  25                  30          


Pro Ala Ala Leu His Ala Leu Gly Ala Arg Leu Gly Ser Ala Val Lys 
        35                  40                  45              


Ile Ser Leu Pro Asp Gly Gly Ser Cys Leu Cys Thr Ala Trp Pro Arg 
    50                  55                  60                  


Arg Asp Gly Ala Asp Gly Phe Val Gln Leu Asp Pro Leu Cys Ala Ser 
65                  70                  75                  80  


Pro Gly Ala Ala Val Gly Ala Ser Arg Ser Arg Arg Ser Leu Ser Leu 
                85                  90                  95      


Asn Arg Leu Leu Leu Val Pro Cys Pro Pro Leu Arg Arg Val Ala Val 
            100                 105                 110         


Trp Pro Val Leu Arg Glu Arg Ala Gly Ala Pro Gly Ala Arg Asn Thr 
        115                 120                 125             


Ala Ala Val Leu Glu Ala Ala Gln Glu Leu Leu Arg Asn Arg Pro Ile 
    130                 135                 140                 


Ser Leu Gly His Val Val Val Ala Pro Pro Gly Ala Pro Gly Leu Val 
145                 150                 155                 160 


Ala Ala Leu His Ile Val Gly Gly Thr Pro Ser Pro Asp Pro Ala Gly 
                165                 170                 175     


Leu Val Thr Pro Arg Thr Arg Val Ser Leu Gly Gly Glu Pro Pro Ser 
            180                 185                 190         


Glu Ala Gln Pro Gln Pro Glu Val Pro Leu Gly Gly Leu Ser Glu Ala 
        195                 200                 205             


Ala Asp Ser Leu Arg Glu Leu Leu Arg Leu Pro Leu Arg Tyr Pro Arg 
    210                 215                 220                 


Ala Leu Thr Ala Leu Gly Leu Ala Val Pro Arg Gly Val Leu Leu Ala 
225                 230                 235                 240 


Gly Pro Pro Gly Val Gly Lys Thr Gln Leu Val Gln Ala Val Ala Arg 
                245                 250                 255     


Glu Ala Gly Ala Glu Leu Leu Ala Val Ser Ala Pro Ala Leu Gln Gly 
            260                 265                 270         


Ser Arg Pro Gly Glu Thr Glu Glu Asn Val Arg Arg Val Phe Gln Arg 
        275                 280                 285             


Ala Arg Glu Leu Ala Ser Arg Gly Pro Ser Leu Leu Phe Leu Asp Glu 
    290                 295                 300                 


Met Asp Ala Leu Cys Pro Gln Arg Gly Ser Arg Ala Pro Glu Ser Arg 
305                 310                 315                 320 


Val Val Ala Gln Val Leu Thr Leu Leu Asp Gly Ala Ser Gly Asp Arg 
                325                 330                 335     


Glu Val Val Val Val Gly Ala Thr Asn Arg Pro Asp Ala Leu Asp Pro 
            340                 345                 350         


Ala Leu Arg Arg Pro Gly Arg Phe Asp Arg Glu Val Val Ile Gly Thr 
        355                 360                 365             


Pro Thr Leu Lys Gln Arg Lys Glu Ile Leu Gln Val Ile Thr Ser Lys 
    370                 375                 380                 


Met Pro Ile Ser Ser His Val Asp Leu Gly Leu Leu Ala Glu Met Thr 
385                 390                 395                 400 


Val Gly Tyr Val Gly Ala Asp Leu Thr Ala Leu Cys Arg Glu Ala Ala 
                405                 410                 415     


Met His Ala Leu Leu His Ser Glu Lys Asn Gln Asp Asn Pro Val Ile 
            420                 425                 430         


Asp Glu Ile Asp Phe Leu Glu Ala Phe Lys Asn Ile Gln Pro Ser Ser 
        435                 440                 445             


Phe Arg Ser Val Ile Gly Leu Met Asp Ile Lys Pro Val Asp Trp Glu 
    450                 455                 460                 


Glu Ile Gly Gly Leu Glu Asp Val Lys Leu Lys Leu Lys Gln Ser Ile 
465                 470                 475                 480 


Glu Trp Pro Leu Lys Phe Pro Trp Glu Phe Val Arg Met Gly Leu Thr 
                485                 490                 495     


Gln Pro Lys Gly Val Leu Leu Tyr Gly Pro Pro Gly Cys Ala Lys Thr 
            500                 505                 510         


Thr Leu Val Arg Ala Leu Ala Thr Ser Cys His Cys Ser Phe Val Ser 
        515                 520                 525             


Val Ser Gly Ala Asp Leu Phe Ser Pro Phe Val Gly Asp Ser Glu Lys 
    530                 535                 540                 


Val Leu Ser Gln Ile Phe Arg Gln Ala Arg Ala Ser Thr Pro Ala Ile 
545                 550                 555                 560 


Leu Phe Leu Asp Glu Ile Asp Ser Ile Leu Gly Ala Arg Ser Ala Ser 
                565                 570                 575     


Lys Thr Gly Cys Asp Val Gln Glu Arg Val Leu Ser Val Leu Leu Asn 
            580                 585                 590         


Glu Leu Asp Gly Val Gly Leu Lys Thr Ile Glu Arg Arg Gly Ser Lys 
        595                 600                 605             


Ser Ser Gln Gln Glu Phe Gln Glu Val Phe Asn Arg Ser Val Met Ile 
    610                 615                 620                 


Ile Ala Ala Thr Asn Arg Pro Asp Val Leu Asp Thr Ala Leu Leu Arg 
625                 630                 635                 640 


Pro Gly Arg Leu Asp Lys Ile Ile Tyr Ile Pro Pro Pro Asp His Lys 
                645                 650                 655     


Gly Arg Leu Ser Ile Leu Lys Val Cys Thr Lys Thr Met Pro Ile Gly 
            660                 665                 670         


Pro Asp Val Ser Leu Glu Asn Leu Ala Ala Glu Thr Cys Phe Phe Ser 
        675                 680                 685             


Gly Ala Asp Leu Arg Asn Leu Cys Thr Glu Ala Ala Leu Leu Ala Leu 
    690                 695                 700                 


Gln Glu Asn Gly Leu Asp Ala Thr Thr Val Lys Gln Glu His Phe Leu 
705                 710                 715                 720 


Lys Ser Leu Lys Thr Val Lys Pro Ser Leu Ser Cys Lys Asp Leu Ala 
                725                 730                 735     


Leu Tyr Glu Asn Leu Phe Lys Lys Glu Gly Phe Ser Asn Val Glu Gly 
            740                 745                 750         


Ile 
    


<210>  3220
<211>  929
<212>  DNA
<213>  Homosapiens

<400>  3220
cggttgtggt cgctatatat aaggtgggga ggccgccggc ccgttcggtt ccgggcgtta     60

ccatcgtccg tgcgcaccgc ccggcgtcca ggtgagtctc ccatctgcag agacgcggac    120

gcgccggccc gcagttggcc tgcggagcgc ggtggacggt ttggcgccca ccaggcgatc    180

aatactttgg atttttaatt tctagatttg gcaattcttc gctgaagtca tcatgagctt    240

tttccaactc ctgatgaaaa ggaaggaact cattcccttg gtggtgttca tgactgtggc    300

ggcgggtgga gcctcatctt tcgctgtgta ttctctttgg aaaaccgatg tgatccttga    360

tcgaaaaaaa aatccagaac cttgggaaac tgtggaccct actgtacctc aaaagcttat    420

aacaatcaac caacaatgga aacccattga agagttgcaa aatgtccaaa gggtgaccaa    480

atgacgagcc ctcgcctctt tcttctgaag agtactctat aaatctagtg gaaacatttc    540

tgcacaaact agattctgga caccagtgtg cggaaatgct tctgctacat ttttagggtt    600

tgtctacatt ttttgggctc tggataagga attaaaggag tgcagcaata actgcactgt    660

ctaaaagttt gtgcttattt tcttgtaaat ttgaatattg catattgaaa tttttgttta    720

tgatctatga atgtttttct taaaatttac aaagctttgt aaattagatt ttctttaata    780

aaatgccatt tgtgcaagat ttctcaaaga ttaggtatat atttaaatgg aagagaaaat    840

atttttatgg gagaaaaata catttgaacc atgaaatttc atcttttaaa taacatccag    900

tacagatttc tgtgtaaaaa aaaaaaaaa                                      929


<210>  3221
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  3221

Met Ser Phe Phe Gln Leu Leu Met Lys Arg Lys Glu Leu Ile Pro Leu 
1               5                   10                  15      


Val Val Phe Met Thr Val Ala Ala Gly Gly Ala Ser Ser Phe Ala Val 
            20                  25                  30          


Tyr Ser Leu Trp Lys Thr Asp Val Ile Leu Asp Arg Lys Lys Asn Pro 
        35                  40                  45              


Glu Pro Trp Glu Thr Val Asp Pro Thr Val Pro Gln Lys Leu Ile Thr 
    50                  55                  60                  


Ile Asn Gln Gln Trp Lys Pro Ile Glu Glu Leu Gln Asn Val Gln Arg 
65                  70                  75                  80  


Val Thr Lys 
            


<210>  3222
<211>  815
<212>  DNA
<213>  Homosapiens

<400>  3222
cggttgtggt cgctatatat aaggtgggga ggccgccggc ccgttcggtt ccgggcgtta     60

ccatcgtccg tgcgcaccgc ccggcgtcca gatttggcaa ttcttcgctg aagtcatcat    120

gagctttttc caactcctga tgaaaaggaa ggaactcatt cccttggtgg tgttcatgac    180

tgtggcggcg ggtggagcct catctttcgc tgtgtattct ctttggaaaa ccgatgtgat    240

ccttgatcga aaaaaaaatc cagaaccttg ggaaactgtg gaccctactg tacctcaaaa    300

gcttataaca atcaaccaac aatggaaacc cattgaagag ttgcaaaatg tccaaagggt    360

gaccaaatga cgagccctcg cctctttctt ctgaagagta ctctataaat ctagtggaaa    420

catttctgca caaactagat tctggacacc agtgtgcgga aatgcttctg ctacattttt    480

agggtttgtc tacatttttt gggctctgga taaggaatta aaggagtgca gcaataactg    540

cactgtctaa aagtttgtgc ttattttctt gtaaatttga atattgcata ttgaaatttt    600

tgtttatgat ctatgaatgt ttttcttaaa atttacaaag ctttgtaaat tagattttct    660

ttaataaaat gccatttgtg caagatttct caaagattag gtatatattt aaatggaaga    720

gaaaatattt ttatgggaga aaaatacatt tgaaccatga aatttcatct tttaaataac    780

atccagtaca gatttctgtg taaaaaaaaa aaaaa                               815


<210>  3223
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  3223

Met Ser Phe Phe Gln Leu Leu Met Lys Arg Lys Glu Leu Ile Pro Leu 
1               5                   10                  15      


Val Val Phe Met Thr Val Ala Ala Gly Gly Ala Ser Ser Phe Ala Val 
            20                  25                  30          


Tyr Ser Leu Trp Lys Thr Asp Val Ile Leu Asp Arg Lys Lys Asn Pro 
        35                  40                  45              


Glu Pro Trp Glu Thr Val Asp Pro Thr Val Pro Gln Lys Leu Ile Thr 
    50                  55                  60                  


Ile Asn Gln Gln Trp Lys Pro Ile Glu Glu Leu Gln Asn Val Gln Arg 
65                  70                  75                  80  


Val Thr Lys 
            


<210>  3224
<211>  4290
<212>  DNA
<213>  Homosapiens

<400>  3224
gcagggcggg gagaggcggt ggctgtgggc gtccggcccc gaacctgtca gacctgggga     60

gccggcctcc agcagcgggc gcggcgggcg cgagcacgac cccactctcc tgcggccgcg    120

ggtggagcag cgcgagcccg cctcgctgag ccggccgggg gcggggagat gagttgcggc    180

cccgcggcag cgccccagga tggggaggga cgcgcggcac tgccctcgag aactggcgct    240

ccggtgaagt aggcgccgcc ggccgtccgc ctcccccaag ccgttccgca ccgcggccgc    300

tcagcctctg ccatggccgg ctctggcgcg tggaagcgcc tcaaatctat gctaaggaag    360

gatgatgcgc cgctgttttt aaatgacacc agcgcctttg acttctcgga tgaggcgggg    420

gacgaggggc tttctcggtt caacaaactt cgagttgtgg tggccgatga cggttccgaa    480

gccccggaaa ggcctgttaa cggggcgcac ccgaccctcc aggccgacga tgattcctta    540

ctggaccaag acttaccttt gaccaacagt cagctgagtt tgaaggtgga ctcctgtgac    600

aactgcagca aacagagaga gatactgaag cagagaaagg tgaaagccag gttgaccatt    660

gctgccgttc tgtacttgct tttcatgatt ggagaacttg taggtggata cattgcaaat    720

agcctagcaa tcatgacaga tgcacttcat atgttaactg acctaagcgc catcatactc    780

accctgcttg ctttgtggct atcatcaaaa tcaccaacca aaagattcac ctttggattt    840

catcgcttag aggttttgtc agctatgatt agtgtgctgt tggtgtatat acttatggga    900

ttcctcttat atgaagctgt gcaaagaact atccatatga actatgaaat aaatggagat    960

ataatgctca tcaccgcagc tgttggagtt gcagttaatg taataatggg gtttctgttg   1020

aaccagtctg gtcaccgtca ctcccattcc cactccctgc cttcaaattc ccctaccaga   1080

ggttctgggt gtgaacgtaa ccatgggcag gatagcctgg cagtgagagc tgcatttgta   1140

catgctttgg gagatttggt acagagtgtt ggtgtgctaa tagctgcata catcatacga   1200

ttcaagccag aatacaagat tgctgacccc atctgtacat acgtattttc attacttgtg   1260

gcttttacaa catttcgaat catatgggat acagtagtta taatactaga aggtgtgcca   1320

agccatttga atgtagacta tatcaaagaa gccttgatga aaatagaaga tgtatattca   1380

gtcgaagatt taaatatctg gtctctcact tcaggaaaat ctactgccat agttcacata   1440

cagctaattc ctggaagttc atctaaatgg gaggaagtac agtccaaagc aaaccattta   1500

ttattgaaca catttggcat gtatagatgt actattcagc ttcagagtta caggcaagaa   1560

gtggacagaa cttgtgcaaa ttgtcagagt tctagtccct aattttatgt attttgggaa   1620

ctcctgcctt atttatcctg cagtcacaga cttgagagca ataaatgcaa acctaaatga   1680

gaaaatggaa tccctgacag ctgtgtccgt atcaagcatc agtctctcaa acagttgccc   1740

cagcctgaca gtgctagtct ctgtttaatg gtaaaaggag actttgccat aattttcaga   1800

tgaagatgtt tcccaaacac tgtttacaga atgagatgtg actctacaga tacctcatag   1860

aagacaatcc aagatcatac ttcattaact tgacagagta cgtgtcttaa aggaagcatc   1920

aagaattcaa tatttgcatt taaaaatact ttttaaggcc attttatatt aagccagtgc   1980

tggaaaactg aatttttttt attatgtata ataatctcga cacccagctt ctggaattgc   2040

tgctttcttt ttacagaaat tactacccaa cagatttcag gaagtactag tagttatccc   2100

aaaagtggaa taagcatgta ttcctaagtg tttcagaaat gttttatttc acacataagt   2160

cttaatgtta ttgttatgat tatactttat aaacaacctt ttccagatgc tacagggttt   2220

tgaatctcaa agttaacatt tttcattatt tgtaatctta gaaccaaatc tttatttatt   2280

gtggtcactg ttattaaatg atttaggaaa tactttcaat attattctga atggctgaag   2340

ttagtcttaa actcaaatta ctatatgatg atttaaaaca aaataaaaga gcgaggatgg   2400

gggttggagt ttcaggttta tgtcttcccg acatcacttt tatcattcat gaaattgtct   2460

taaaaaagca agagactgca aaatgtaaac agtaatcttc tgtcccttta agaactgcca   2520

acaatttgta caaaaaatgt ggtacgttgg ttcctgcctc cactccaggt catctgtgtg   2580

tttagccttt cagggtaaac tctagagggt tcagtttata attcccacct ttcacatata   2640

gttcaacaac attaatccag agagaatttt atgttttatg atatgggtta tgttttatta   2700

tatattttat gttttatgat atgggttagg gattctccat ggactccaga aaccctaaaa   2760

tacaattttg aggttttcca ataataccat agcagaaatg tccaaggggt tgggggaaga   2820

tattactttg agaaaacaga aatgtaaagg atttttgacc ttatatatgt gtgtggtttt   2880

gtttttgttt ttgttcttga gagagtctca ctctgtcacc caggctggag tgcagtggcg   2940

tgacctctgc tcactgtaac ctctgcctcc tgggttcaag tgattcttct gcctcagcct   3000

cccaactagc tgggactaca ggtacaccac acccagctca tttttttgta tttttagtag   3060

agacagggtt ttgccacatt ggcctgtctg gtcttgaact cctgacctca ggtgatccgc   3120

ctgccttggc cttccagagt gctgggatta cagcatgagc caccatgcct ggcctgtatg   3180

tgtgtgtttt aaagcactag atagggatgg acattaaatc tgtgttgcag ggaaactaaa   3240

cagaggtttc caaactgaag gcaacctaat tgtaaatgcc tgtgttaaag aggcagcttg   3300

actgttcatg tttcattttg caaccattgg ttttgagatt atcttttatg cacatttgga   3360

gtcccttttc aacagtgaca gtttcttaca cgaagaatgg atatggttat tgggctcctc   3420

taagaatcag agtagggtaa caatgtacca ggcaaattgt aagttgaaat tctagataag   3480

catgcagatg acttacaata taaatgaaga ataggaaaca ttttatcttc ttaccaagta   3540

ccttactata agtaaaccta agataagaaa acccagattt acctataaga ttgttgggag   3600

ttaatggtgt caataaaagg attgatggtc cctctaatga aacccagtag atgtttgttg   3660

aattgaactg aaaatttatg tggccagaca cagtggctca tgcctgtaat ctcagcattt   3720

ggggaggcaa aggtggaagt atccctcgag gccaagagtt catgaccagc ctggtctttt   3780

gtagagaccc tgtctctaca aaaatataaa aatcagccag gcgtcgtgca cacctgtagt   3840

atcagctact tgtaaggctg tggcagaagt gctttagccc aggaggttga ggctgcagtg   3900

agccatgtcc acaccattgc actgcagcct gagtaacaaa atgagaccct atctcaaaaa   3960

caaaaaggaa aagaaaatat acatgatggg attcctattg tgaagtcatt taaaataatg   4020

acttgaattt ctcagaaatt tcaggagcat ataaactatt taaatcaaaa tattcttaca   4080

tatagaaacc aagtaagaat aaatgagaga tatttcagtg gacatctgga catatttatg   4140

gactttgagt atctagcaag tagaaaggaa aaaaatattc atcatactct aatcattttt   4200

ttatatctat tgagcttgtt tcttgtaaac ttttctttat cttataaagg catatctcgc   4260

ttttgtatcg acctgttcct taaaaaaaaa                                    4290


<210>  3225
<211>  429
<212>  PRT
<213>  Homosapiens

<400>  3225

Met Ala Gly Ser Gly Ala Trp Lys Arg Leu Lys Ser Met Leu Arg Lys 
1               5                   10                  15      


Asp Asp Ala Pro Leu Phe Leu Asn Asp Thr Ser Ala Phe Asp Phe Ser 
            20                  25                  30          


Asp Glu Ala Gly Asp Glu Gly Leu Ser Arg Phe Asn Lys Leu Arg Val 
        35                  40                  45              


Val Val Ala Asp Asp Gly Ser Glu Ala Pro Glu Arg Pro Val Asn Gly 
    50                  55                  60                  


Ala His Pro Thr Leu Gln Ala Asp Asp Asp Ser Leu Leu Asp Gln Asp 
65                  70                  75                  80  


Leu Pro Leu Thr Asn Ser Gln Leu Ser Leu Lys Val Asp Ser Cys Asp 
                85                  90                  95      


Asn Cys Ser Lys Gln Arg Glu Ile Leu Lys Gln Arg Lys Val Lys Ala 
            100                 105                 110         


Arg Leu Thr Ile Ala Ala Val Leu Tyr Leu Leu Phe Met Ile Gly Glu 
        115                 120                 125             


Leu Val Gly Gly Tyr Ile Ala Asn Ser Leu Ala Ile Met Thr Asp Ala 
    130                 135                 140                 


Leu His Met Leu Thr Asp Leu Ser Ala Ile Ile Leu Thr Leu Leu Ala 
145                 150                 155                 160 


Leu Trp Leu Ser Ser Lys Ser Pro Thr Lys Arg Phe Thr Phe Gly Phe 
                165                 170                 175     


His Arg Leu Glu Val Leu Ser Ala Met Ile Ser Val Leu Leu Val Tyr 
            180                 185                 190         


Ile Leu Met Gly Phe Leu Leu Tyr Glu Ala Val Gln Arg Thr Ile His 
        195                 200                 205             


Met Asn Tyr Glu Ile Asn Gly Asp Ile Met Leu Ile Thr Ala Ala Val 
    210                 215                 220                 


Gly Val Ala Val Asn Val Ile Met Gly Phe Leu Leu Asn Gln Ser Gly 
225                 230                 235                 240 


His Arg His Ser His Ser His Ser Leu Pro Ser Asn Ser Pro Thr Arg 
                245                 250                 255     


Gly Ser Gly Cys Glu Arg Asn His Gly Gln Asp Ser Leu Ala Val Arg 
            260                 265                 270         


Ala Ala Phe Val His Ala Leu Gly Asp Leu Val Gln Ser Val Gly Val 
        275                 280                 285             


Leu Ile Ala Ala Tyr Ile Ile Arg Phe Lys Pro Glu Tyr Lys Ile Ala 
    290                 295                 300                 


Asp Pro Ile Cys Thr Tyr Val Phe Ser Leu Leu Val Ala Phe Thr Thr 
305                 310                 315                 320 


Phe Arg Ile Ile Trp Asp Thr Val Val Ile Ile Leu Glu Gly Val Pro 
                325                 330                 335     


Ser His Leu Asn Val Asp Tyr Ile Lys Glu Ala Leu Met Lys Ile Glu 
            340                 345                 350         


Asp Val Tyr Ser Val Glu Asp Leu Asn Ile Trp Ser Leu Thr Ser Gly 
        355                 360                 365             


Lys Ser Thr Ala Ile Val His Ile Gln Leu Ile Pro Gly Ser Ser Ser 
    370                 375                 380                 


Lys Trp Glu Glu Val Gln Ser Lys Ala Asn His Leu Leu Leu Asn Thr 
385                 390                 395                 400 


Phe Gly Met Tyr Arg Cys Thr Ile Gln Leu Gln Ser Tyr Arg Gln Glu 
                405                 410                 415     


Val Asp Arg Thr Cys Ala Asn Cys Gln Ser Ser Ser Pro 
            420                 425                 


<210>  3226
<211>  1927
<212>  DNA
<213>  Homosapiens

<400>  3226
acctaagcga tgaaatccaa aggtgaatct tttggttggt gattttgatg atagccacaa     60

agcaagcagg ctgtatggta gccttgaaaa ccaacaggcc acaatcacag tgaaaacctc    120

aggttggcag ccactggagg atacaaaatg agtttggatc tccttcaatg ccccattccc    180

agagaactgt cattatttga cctgctggta gttccctaaa ggacgtgcaa ggatgttttt    240

atttgactgg acacttgaag cttgccctgt atgaacagcc cccatcttcc catgcttgtc    300

aaaaatcaga ggcaactaac actgcggctt cctgagagtc tcactctgtc acccaggctg    360

gagagcaatt gcacaaacac ttggctcact gcagcctcaa cttcttgtcc tcaagtgatc    420

ctcccacctt agcctcctaa gtagctggga ccacagggaa ctccggatgt gactcctgtt    480

acatgaaaat ggaagaggtc agagttgtcc aagagggagg ccagccacat ccaggcaggg    540

cccccatggt cagaaccctg ctagagccat caaggtccca gagctcccaa gatggtggca    600

agccttttgt tctctgacca gaggttcctg gcctcacgga ttccaaggaa tggaaccttg    660

ggccatgcgt gcacttgatt ttgcagatga gtctggaagt gttagttgca aagatatgca    720

tttacttctc tggctacaaa aaagaataga aatgcacaaa gcagagcagt gtgaagaaga    780

agaggcgatg acccctagac cgaccaaagc ccgtgctcca ctgcccagtg cctatgtccc    840

accactgtcg ctgccaccct gcccgagaga aaggctgaag gggatgctaa aggagataaa    900

accaaggtta agtaggaact gcagagaaga tccacaaggt tgtctgctaa acctgctcct    960

ccaaagccac agccgaagcc cagaaaggcc tctgcaaaga agagagagaa ggtacctaca   1020

gagaagaagg gaaaagctga tgctggcaag gaggggaata accctgcaga aaatggagat   1080

gccaaaacag actaggcaca gaaagctaaa ggtgctggag atgccaagtg aagtgtgtgc   1140

atttttgata actgtgtact tctggtgact gtacagtttg aaatactatt ttttaatcaa   1200

gttttataaa aatgcagatt ttgtttagct tttttttttt tttttaagct atgttagtac   1260

acagaatact tcattgttgt tttggggaga agggccatat gtcactaata gaaagcccct   1320

gaagctggac tgatgtgggg aaaacacctt ttccttctgg ttttgagaga cttcctcttg   1380

ggtcccagga agagggattc cctgactttg atacacatgg ccaccttggt ataaaagcct   1440

tgtggtatgg aaaaacaaat tcgtttttta tgtcctcttc tctgtttcta cctttcagaa   1500

tggacttaaa tcccttaaac ccagacatct tctgggacct gacccccaat aattggttac   1560

cagtgtgtca ggcaatctgg actttgccct caaaagagca gtggttcctg tttctaggtt   1620

gtggatcttc agataaattc tgtcattttc ctttcacttc ctgaaagcca gggtcggttc   1680

atgaaaagct atgaaacagc atgctaaatg tgaaatgtca accctcacta aactttgccg   1740

gttcagagca tcagatgaag acttcattgg gttttacagt ggctttctga tttttggtag   1800

tccattgaag aagggagttt gaaagttgtt gtatactgtt aacgattgtc tgcccatgtc   1860

ctgcccaaaa taccatgatt ctttatggaa attatcttta ataaagctgg atacagtttg   1920

gcttggg                                                             1927


<210>  3227
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  3227

Met Glu Pro Trp Ala Met Arg Ala Leu Asp Phe Ala Asp Glu Ser Gly 
1               5                   10                  15      


Ser Val Ser Cys Lys Asp Met His Leu Leu Leu Trp Leu Gln Lys Arg 
            20                  25                  30          


Ile Glu Met His Lys Ala Glu Gln Cys Glu Glu Glu Glu Ala Met Thr 
        35                  40                  45              


Pro Arg Pro Thr Lys Ala Arg Ala Pro Leu Pro Ser Ala Tyr Val Pro 
    50                  55                  60                  


Pro Leu Ser Leu Pro Pro Cys Pro Arg Glu Arg Leu Lys Gly Met Leu 
65                  70                  75                  80  


Lys Glu Ile Lys Pro Arg Leu Ser Arg Asn Cys Arg Glu Asp Pro Gln 
                85                  90                  95      


Gly Cys Leu Leu Asn Leu Leu Leu Gln Ser His Ser Arg Ser Pro Glu 
            100                 105                 110         


Arg Pro Leu Gln Arg Arg Glu Arg Arg Tyr Leu Gln Arg Arg Arg Glu 
        115                 120                 125             


Lys Leu Met Leu Ala Arg Arg Gly Ile Thr Leu Gln Lys Met Glu Met 
    130                 135                 140                 


Pro Lys Gln Thr Arg His Arg Lys Leu Lys Val Leu Glu Met Pro Ser 
145                 150                 155                 160 


Glu Val Cys Ala Phe Leu Ile Thr Val Tyr Phe Trp 
                165                 170         


<210>  3228
<211>  1682
<212>  DNA
<213>  Homosapiens

<400>  3228
acctaagcga tgaaatccaa aggtgaatct tttggttggt gattttgatg atagccacaa     60

agcaagcagg ctgtatggta gccttgaaaa ccaacaggcc acaatcacag tgaaaacctc    120

aggttggcag ccactggagg atacaaaatg agtttggatc tccttcaatg ccccattccc    180

agagaactgt cattatttga cctgctggta gttccctaaa ggacgtgcaa ggatgttttt    240

atttgactgg acacttgaag cttgccctgt atgaacagcc cccatcttcc catgcttgtc    300

aaaaatcaga ggcaactaac actgcggctt cctgagagct cccaagatgg tggcaagcct    360

tttgttctct gaccagaggt tcctggcctc acggattcca aggaatggaa ccttgggcca    420

tgcgtgcact tgattttgca gatgagtctg gaagtgttag ttgcaaagat atgcatttac    480

ttctctggct acaaaaaaga atagaaatgc acaaagcaga gcagtgtgaa gaagaagagg    540

cgatgacccc tagaccgacc aaagcccgtg ctccactgcc cagtgcctat gtcccaccac    600

tgtcgctgcc accctgcccg agagaaaggc tgaaggggat gctaaaggag ataaaaccaa    660

ggttaagtag gaactgcaga gaagatccac aaggttgtct gctaaacctg ctcctccaaa    720

gccacagccg aagcccagaa aggcctctgc aaagaagaga gagaaggtac ctacagagaa    780

gaagggaaaa gctgatgctg gcaaggaggg gaataaccct gcagaaaatg gagatgccaa    840

aacagactag gcacagaaag ctaaaggtgc tggagatgcc aagtgaagtg tgtgcatttt    900

tgataactgt gtacttctgg tgactgtaca gtttgaaata ctatttttta atcaagtttt    960

ataaaaatgc agattttgtt tagctttttt tttttttttt aagctatgtt agtacacaga   1020

atacttcatt gttgttttgg ggagaagggc catatgtcac taatagaaag cccctgaagc   1080

tggactgatg tggggaaaac accttttcct tctggttttg agagacttcc tcttgggtcc   1140

caggaagagg gattccctga ctttgataca catggccacc ttggtataaa agccttgtgg   1200

tatggaaaaa caaattcgtt ttttatgtcc tcttctctgt ttctaccttt cagaatggac   1260

ttaaatccct taaacccaga catcttctgg gacctgaccc ccaataattg gttaccagtg   1320

tgtcaggcaa tctggacttt gccctcaaaa gagcagtggt tcctgtttct aggttgtgga   1380

tcttcagata aattctgtca ttttcctttc acttcctgaa agccagggtc ggttcatgaa   1440

aagctatgaa acagcatgct aaatgtgaaa tgtcaaccct cactaaactt tgccggttca   1500

gagcatcaga tgaagacttc attgggtttt acagtggctt tctgattttt ggtagtccat   1560

tgaagaaggg agtttgaaag ttgttgtata ctgttaacga ttgtctgccc atgtcctgcc   1620

caaaatacca tgattcttta tggaaattat ctttaataaa gctggataca gtttggcttg   1680

gg                                                                  1682


<210>  3229
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  3229

Met Glu Pro Trp Ala Met Arg Ala Leu Asp Phe Ala Asp Glu Ser Gly 
1               5                   10                  15      


Ser Val Ser Cys Lys Asp Met His Leu Leu Leu Trp Leu Gln Lys Arg 
            20                  25                  30          


Ile Glu Met His Lys Ala Glu Gln Cys Glu Glu Glu Glu Ala Met Thr 
        35                  40                  45              


Pro Arg Pro Thr Lys Ala Arg Ala Pro Leu Pro Ser Ala Tyr Val Pro 
    50                  55                  60                  


Pro Leu Ser Leu Pro Pro Cys Pro Arg Glu Arg Leu Lys Gly Met Leu 
65                  70                  75                  80  


Lys Glu Ile Lys Pro Arg Leu Ser Arg Asn Cys Arg Glu Asp Pro Gln 
                85                  90                  95      


Gly Cys Leu Leu Asn Leu Leu Leu Gln Ser His Ser Arg Ser Pro Glu 
            100                 105                 110         


Arg Pro Leu Gln Arg Arg Glu Arg Arg Tyr Leu Gln Arg Arg Arg Glu 
        115                 120                 125             


Lys Leu Met Leu Ala Arg Arg Gly Ile Thr Leu Gln Lys Met Glu Met 
    130                 135                 140                 


Pro Lys Gln Thr Arg His Arg Lys Leu Lys Val Leu Glu Met Pro Ser 
145                 150                 155                 160 


Glu Val Cys Ala Phe Leu Ile Thr Val Tyr Phe Trp 
                165                 170         


<210>  3230
<211>  1702
<212>  DNA
<213>  Homosapiens

<400>  3230
acctaagcga tgaaatccaa aggtgaatct tttggttggt gattttgatg atagccacaa     60

agcaagcagg ctgtatggta gccttgaaaa ccaacaggcc acaatcacag tgaaaacctc    120

aggttggcag ccactggagg atacaaaatg agtttggatc tccttcaatg ccccattccc    180

agagaactgt cattatttga cctgctggta gttccctaaa ggacgtgcaa ggatgttttt    240

atttgactgg acacttgaag cttgccctgt atgaacagcc cccatcttcc catgcttgtc    300

aaaaatcaga ggcaactaac actgcggctt cctgagggaa ctccggatgt gactcctgtt    360

acatgaaaat ggaagaggtc agagttgtcc aagagggagg ccagccacat ccaggcaggg    420

cccccatggt cagaaccctg ctagagccat caaggtccca gatgagtctg gaagtgttag    480

ttgcaaagat atgcatttac ttctctggct acaaaaaaga atagaaatgc acaaagcaga    540

gcagtgtgaa gaagaagagg cgatgacccc tagaccgacc aaagcccgtg ctccactgcc    600

cagtgcctat gtcccaccac tgtcgctgcc accctgcccg agagaaaggc tgaaggggat    660

gctaaaggag ataaaaccaa ggttaagtag gaactgcaga gaagatccac aaggttgtct    720

gctaaacctg ctcctccaaa gccacagccg aagcccagaa aggcctctgc aaagaagaga    780

gagaaggtac ctacagagaa gaagggaaaa gctgatgctg gcaaggaggg gaataaccct    840

gcagaaaatg gagatgccaa aacagactag gcacagaaag ctaaaggtgc tggagatgcc    900

aagtgaagtg tgtgcatttt tgataactgt gtacttctgg tgactgtaca gtttgaaata    960

ctatttttta atcaagtttt ataaaaatgc agattttgtt tagctttttt tttttttttt   1020

aagctatgtt agtacacaga atacttcatt gttgttttgg ggagaagggc catatgtcac   1080

taatagaaag cccctgaagc tggactgatg tggggaaaac accttttcct tctggttttg   1140

agagacttcc tcttgggtcc caggaagagg gattccctga ctttgataca catggccacc   1200

ttggtataaa agccttgtgg tatggaaaaa caaattcgtt ttttatgtcc tcttctctgt   1260

ttctaccttt cagaatggac ttaaatccct taaacccaga catcttctgg gacctgaccc   1320

ccaataattg gttaccagtg tgtcaggcaa tctggacttt gccctcaaaa gagcagtggt   1380

tcctgtttct aggttgtgga tcttcagata aattctgtca ttttcctttc acttcctgaa   1440

agccagggtc ggttcatgaa aagctatgaa acagcatgct aaatgtgaaa tgtcaaccct   1500

cactaaactt tgccggttca gagcatcaga tgaagacttc attgggtttt acagtggctt   1560

tctgattttt ggtagtccat tgaagaaggg agtttgaaag ttgttgtata ctgttaacga   1620

ttgtctgccc atgtcctgcc caaaatacca tgattcttta tggaaattat ctttaataaa   1680

gctggataca gtttggcttg gg                                            1702


<210>  3231
<211>  150
<212>  PRT
<213>  Homosapiens

<400>  3231

Met His Leu Leu Leu Trp Leu Gln Lys Arg Ile Glu Met His Lys Ala 
1               5                   10                  15      


Glu Gln Cys Glu Glu Glu Glu Ala Met Thr Pro Arg Pro Thr Lys Ala 
            20                  25                  30          


Arg Ala Pro Leu Pro Ser Ala Tyr Val Pro Pro Leu Ser Leu Pro Pro 
        35                  40                  45              


Cys Pro Arg Glu Arg Leu Lys Gly Met Leu Lys Glu Ile Lys Pro Arg 
    50                  55                  60                  


Leu Ser Arg Asn Cys Arg Glu Asp Pro Gln Gly Cys Leu Leu Asn Leu 
65                  70                  75                  80  


Leu Leu Gln Ser His Ser Arg Ser Pro Glu Arg Pro Leu Gln Arg Arg 
                85                  90                  95      


Glu Arg Arg Tyr Leu Gln Arg Arg Arg Glu Lys Leu Met Leu Ala Arg 
            100                 105                 110         


Arg Gly Ile Thr Leu Gln Lys Met Glu Met Pro Lys Gln Thr Arg His 
        115                 120                 125             


Arg Lys Leu Lys Val Leu Glu Met Pro Ser Glu Val Cys Ala Phe Leu 
    130                 135                 140                 


Ile Thr Val Tyr Phe Trp 
145                 150 


<210>  3232
<211>  1697
<212>  DNA
<213>  Homosapiens

<400>  3232
acctaagcga tgaaatccaa aggtgaatct tttggttggt gattttgatg atagccacaa     60

agcaagcagg ctgtatggta gccttgaaaa ccaacaggcc acaatcacag tgaaaacctc    120

aggttggcag ccactggagg atacaaaatg agtttggatc tccttcaatg ccccattccc    180

agagaactgt cattatttga cctgctggta gttccctaaa ggacgtgcaa ggatgttttt    240

atttgactgg acacttgaag cttgccctgt atgaacagcc cccatcttcc catgcttgtc    300

aaaaatcaga ggcaactaac actgcggctt cctgagagtc tcactctgtc acccaggctg    360

gagagcaatt gcacaaacac ttggctcact gcagcctcaa cttcttgtcc tcaagtgatc    420

ctcccacctt agcctcctaa gtagctggga ccacagatga gtctggaagt gttagttgca    480

aagatatgca tttacttctc tggctacaaa aaagaataga aatgcacaaa gcagagcagt    540

gtgaagaaga agaggcgatg acccctagac cgaccaaagc ccgtgctcca ctgcccagtg    600

cctatgtccc accactgtcg ctgccaccct gcccgagaga aaggctgaag gggatgctaa    660

aggagataaa accaaggtta agtaggaact gcagagaaga tccacaaggt tgtctgctaa    720

acctgctcct ccaaagccac agccgaagcc cagaaaggcc tctgcaaaga agagagagaa    780

ggtacctaca gagaagaagg gaaaagctga tgctggcaag gaggggaata accctgcaga    840

aaatggagat gccaaaacag actaggcaca gaaagctaaa ggtgctggag atgccaagtg    900

aagtgtgtgc atttttgata actgtgtact tctggtgact gtacagtttg aaatactatt    960

ttttaatcaa gttttataaa aatgcagatt ttgtttagct tttttttttt tttttaagct   1020

atgttagtac acagaatact tcattgttgt tttggggaga agggccatat gtcactaata   1080

gaaagcccct gaagctggac tgatgtgggg aaaacacctt ttccttctgg ttttgagaga   1140

cttcctcttg ggtcccagga agagggattc cctgactttg atacacatgg ccaccttggt   1200

ataaaagcct tgtggtatgg aaaaacaaat tcgtttttta tgtcctcttc tctgtttcta   1260

cctttcagaa tggacttaaa tcccttaaac ccagacatct tctgggacct gacccccaat   1320

aattggttac cagtgtgtca ggcaatctgg actttgccct caaaagagca gtggttcctg   1380

tttctaggtt gtggatcttc agataaattc tgtcattttc ctttcacttc ctgaaagcca   1440

gggtcggttc atgaaaagct atgaaacagc atgctaaatg tgaaatgtca accctcacta   1500

aactttgccg gttcagagca tcagatgaag acttcattgg gttttacagt ggctttctga   1560

tttttggtag tccattgaag aagggagttt gaaagttgtt gtatactgtt aacgattgtc   1620

tgcccatgtc ctgcccaaaa taccatgatt ctttatggaa attatcttta ataaagctgg   1680

atacagtttg gcttggg                                                  1697


<210>  3233
<211>  150
<212>  PRT
<213>  Homosapiens

<400>  3233

Met His Leu Leu Leu Trp Leu Gln Lys Arg Ile Glu Met His Lys Ala 
1               5                   10                  15      


Glu Gln Cys Glu Glu Glu Glu Ala Met Thr Pro Arg Pro Thr Lys Ala 
            20                  25                  30          


Arg Ala Pro Leu Pro Ser Ala Tyr Val Pro Pro Leu Ser Leu Pro Pro 
        35                  40                  45              


Cys Pro Arg Glu Arg Leu Lys Gly Met Leu Lys Glu Ile Lys Pro Arg 
    50                  55                  60                  


Leu Ser Arg Asn Cys Arg Glu Asp Pro Gln Gly Cys Leu Leu Asn Leu 
65                  70                  75                  80  


Leu Leu Gln Ser His Ser Arg Ser Pro Glu Arg Pro Leu Gln Arg Arg 
                85                  90                  95      


Glu Arg Arg Tyr Leu Gln Arg Arg Arg Glu Lys Leu Met Leu Ala Arg 
            100                 105                 110         


Arg Gly Ile Thr Leu Gln Lys Met Glu Met Pro Lys Gln Thr Arg His 
        115                 120                 125             


Arg Lys Leu Lys Val Leu Glu Met Pro Ser Glu Val Cys Ala Phe Leu 
    130                 135                 140                 


Ile Thr Val Tyr Phe Trp 
145                 150 


<210>  3234
<211>  1923
<212>  DNA
<213>  Homosapiens

<400>  3234
acctaagcga tgaaatccaa aggtgaatct tttggttggt gattttgatg atagccacaa     60

agcaagcagg gtaatgctga tgcttcaagt cttggaacca cacttcgaga atcactgtta    120

taatgtacag cagaactgca tgatcagctg tatggtagcc ttgaaaacca acaggccaca    180

atcacagtga aaacctcagg ttggcagcca ctggaggata caaaatgagt ttggatctcc    240

ttcaatgccc cattcccaga gaactgtcat tatttgacct gctggtagtt ccctaaagga    300

cgtgcaagga tgtttttatt tgactggaca cttgaagctt gccctgtatg aacagccccc    360

atcttcccat gcttgtcaaa aatcagaggc aactaacact gcggcttcct gagagtctca    420

ctctgtcacc caggctggag agcaattgca caaacacttg gctcactgca gcctcaactt    480

cttgtcctca agtgatcctc ccaccttagc ctcctaagta gctgggacca cagtgaggtc    540

aaaaaatgtt tgaaagccac tgagatagaa ggaccagcca ctttgaacgc cttagaggca    600

aaaagagctt tgtgagttgt aagaggaaaa agaagaccag catggctgaa gcgagccctg    660

gggaggagtg ttatgaaaga agatgagtct ggaagtgtta gttgcaaaga tatgcattta    720

cttctctggc tacaaaaaag aatagaaatg cacaaagcag agcagtgtga agaagaagag    780

gcgatgaccc ctagaccgac caaagcccgt gctccactgc ccagtgccta tgtcccacca    840

ctgtcgctgc caccctgccc gagagaaagg ctgaagggga tgctaaagga gataaaacca    900

aggttaagta ggaactgcag agaagatcca caaggttgtc tgctaaacct gctcctccaa    960

agccacagcc gaagcccaga aaggcctctg caaagaagag agagaaggta cctacagaga   1020

agaagggaaa agctgatgct ggcaaggagg ggaataaccc tgcagaaaat ggagatgcca   1080

aaacagacta ggcacagaaa gctaaaggtg ctggagatgc caagtgaagt gtgtgcattt   1140

ttgataactg tgtacttctg gtgactgtac agtttgaaat actatttttt aatcaagttt   1200

tataaaaatg cagattttgt ttagcttttt tttttttttt taagctatgt tagtacacag   1260

aatacttcat tgttgttttg gggagaaggg ccatatgtca ctaatagaaa gcccctgaag   1320

ctggactgat gtggggaaaa caccttttcc ttctggtttt gagagacttc ctcttgggtc   1380

ccaggaagag ggattccctg actttgatac acatggccac cttggtataa aagccttgtg   1440

gtatggaaaa acaaattcgt tttttatgtc ctcttctctg tttctacctt tcagaatgga   1500

cttaaatccc ttaaacccag acatcttctg ggacctgacc cccaataatt ggttaccagt   1560

gtgtcaggca atctggactt tgccctcaaa agagcagtgg ttcctgtttc taggttgtgg   1620

atcttcagat aaattctgtc attttccttt cacttcctga aagccagggt cggttcatga   1680

aaagctatga aacagcatgc taaatgtgaa atgtcaaccc tcactaaact ttgccggttc   1740

agagcatcag atgaagactt cattgggttt tacagtggct ttctgatttt tggtagtcca   1800

ttgaagaagg gagtttgaaa gttgttgtat actgttaacg attgtctgcc catgtcctgc   1860

ccaaaatacc atgattcttt atggaaatta tctttaataa agctggatac agtttggctt   1920

ggg                                                                 1923


<210>  3235
<211>  163
<212>  PRT
<213>  Homosapiens

<400>  3235

Met Lys Glu Asp Glu Ser Gly Ser Val Ser Cys Lys Asp Met His Leu 
1               5                   10                  15      


Leu Leu Trp Leu Gln Lys Arg Ile Glu Met His Lys Ala Glu Gln Cys 
            20                  25                  30          


Glu Glu Glu Glu Ala Met Thr Pro Arg Pro Thr Lys Ala Arg Ala Pro 
        35                  40                  45              


Leu Pro Ser Ala Tyr Val Pro Pro Leu Ser Leu Pro Pro Cys Pro Arg 
    50                  55                  60                  


Glu Arg Leu Lys Gly Met Leu Lys Glu Ile Lys Pro Arg Leu Ser Arg 
65                  70                  75                  80  


Asn Cys Arg Glu Asp Pro Gln Gly Cys Leu Leu Asn Leu Leu Leu Gln 
                85                  90                  95      


Ser His Ser Arg Ser Pro Glu Arg Pro Leu Gln Arg Arg Glu Arg Arg 
            100                 105                 110         


Tyr Leu Gln Arg Arg Arg Glu Lys Leu Met Leu Ala Arg Arg Gly Ile 
        115                 120                 125             


Thr Leu Gln Lys Met Glu Met Pro Lys Gln Thr Arg His Arg Lys Leu 
    130                 135                 140                 


Lys Val Leu Glu Met Pro Ser Glu Val Cys Ala Phe Leu Ile Thr Val 
145                 150                 155                 160 


Tyr Phe Trp 
            


<210>  3236
<211>  3959
<212>  DNA
<213>  Homosapiens

<400>  3236
acactgcgtc cggggccaga cgacgatatc agcgcggggt ccccacaacg ccatggggca     60

gagccaactc tcgagcgcgt gatcgaagcc cgcagttttt tcgcccccgt cacttccggg    120

tgcgacaatc tcttctgtcc ggccagccgc tggagtcgtt aggtgccgcc ttgcttctga    180

cgagccacac gtttgcttct tccctgtgtt cccagctgga gggacatgag tgtccctggg    240

ccgtcgtctc cggacggggc cctgacacgg ccaccctact gcctggaggc cggggagccg    300

acgcctggtt taagtgacac ttctccagat gaagggttaa tagaggactt gactatagaa    360

gacaaagcag tggagcaact ggcagaagga ttgctttctc attatttgcc agatctgcag    420

agatcaaaac aagccctcca ggaactcaca cagaaccaag ttgtattgtt agacacactg    480

gaacaagaga tttcaaaatt taaagaatgt cattctatgt tggatattaa tgctttgttt    540

gctgaggcta aacactatca tgccaagttg gtgaatataa gaaaagagat gctgatgctt    600

catgaaaaaa catcaaagtt aaaaaaaaga gcacttaaac tgcagcagaa gaggcaaaaa    660

gaagagttgg aaagggagca gcaacgagag aaggagtttg aaagagaaaa gcagttaact    720

gccagaccag ccaaaaggat gtgaaaagtt gtgtttgtgt gttttcttct cctgtcccat    780

atttgggtta tgatgactca agtgtagact gaagttgagg tagtgcctta tgccattatg    840

tcatatgttg aaatccttat tccggtatta ctgtgtctcc atgccttttt tccaagtagc    900

agacgtcatg ttgcatggtt tttgatattt atatgtaagt ttttcaaatt ttgcttaatt    960

ttaaaattta ttattttgat cttgaattat ttataaactg gaaagtggtt tgattattgt   1020

gagtcaaaac tctaagtggt taaaaattag tatgaatttt ttagcttctt aatgaatatg   1080

gatttaaaac tctccagttc ttattttatg aaatgacttg cctttctggt aatacaatgc   1140

tgatttttta gtaattgcct tttcattact ttgttaagaa gaaatgccag ctgtttaatc   1200

acacctaccc ctggaaaaga ggtaaacctt ttgaacagtt gaatttcatc agaagctcta   1260

tagctttttg gtgagaggaa gtgatactct ttattacaag aaacaaggaa ttaacaaaaa   1320

taaggaactt gttgctacct ttcttttctg ttgaacatta aaaataattt ggtttgtgga   1380

ctgggcatgg tggcttatgg aaaagaggtg agcctttgtg aagaacataa tggaaaagtg   1440

catgtacggg aaataacagc actttaggtg tagttcaggt gagcaagatg ccagatagtt   1500

tctactaacc atatactctt tctgcttctt agcgtcgttg tcactgcttc tgtggctttt   1560

gggttcaaag tagattatat atattcctaa agcttggtgg aggtagtgga gctatcacac   1620

actcaaatga gcttgtatat ttataataca atatagtatt atagtaacag ttatcataca   1680

ctgagatata gtttctgtgc ttgtaaaaaa ttcttgaagt gaggccgggt gcggtggctc   1740

atgcctgtaa tcccaacgct ttgggacgcc gaggcgggtg gatcatgagg tcaaaagatt   1800

gagaccatcc tggccaacat ggtgaaaccc cgtctctact agaaatacaa aaattagctg   1860

ggtgtggggg cgtgcgcctg tagtcccagc tacttgggag gctgaggcag gagaattgct   1920

tgaacccagg aggcagaggt tgcagtaagc caagatcgtg ccactgcact ccagccttgg   1980

tgacagagca agactccgtc tccaaaaaaa agaaaaaaaa atttcttgaa gtggaatgat   2040

gtacaccaaa tacccacttt atagataatt acagggatgg tgaaaaatta gtaaatagct   2100

tcacaaaaga ggcagcgtga tacctttagt gttttctaga atttttttct ggatattata   2160

tgtaagaatt tattgtttga gggaaatacg aggtttcatt gtttaaaatc aagagtgtat   2220

tgtttactgt tttacagtat tatttaatat ccaactggtc tccaatctcc attacatagg   2280

gactgtacag agcctgtgaa gatgtatgaa tggtatcttt tataatccac aatacatttc   2340

tggtaagatg gaatcactac ctctgatcac atatcaggct aacgatagag aaagcattag   2400

gtttaagttg agggctaaga actggtttgt ttaaaggttt aaattgttgg aaaagagcat   2460

ttgccttctt taatgaatga tggtctcaca attcagttga ctttgaccta atatttaaga   2520

atataaatat attttatttg aaaggctgag tgttgccctc aaacacttgc taaaactgcc   2580

tagggcagga ttcattaggg cttgcagaca atgtcaccta aattgctgaa tgtactcatt   2640

ataatatgat atctgacaaa ggtagtacag cgtttctgag tcatttggga ccaactgcag   2700

tggttgttta aaatgctggt tcctgcacac aattctctat ctactgaagc acatctgttt   2760

tctttgtttg ttttgctttg ctttttgttt ttaaagtttc ccccagtgat tccagtgcac   2820

ctgaaaagtt gagaaccaca ggcttagtgg tacgttgggg tttcccacgc taggctgcat   2880

agcattataa cctgggaacg ttaaaaaaaa tacagacatt cttgattctt agtgtagtta   2940

tgatgtggat cctacgtatt ttttaaaaaa ctctccagat aattttgatg tcacgagtca   3000

ctagtataga ctatctatct agtgagttgt attataagcg atgaaatact ttaaaagcta   3060

cccagtaact cttgggatta attttatgaa ataaattctg agctgctgct tttgatatag   3120

tcagacttaa gactgaaccc cagtagacag gcaatagata tagaattctg gttagctaat   3180

tgaacttttg tgacctgttt aaaaacaaat caaatttatt gaacaaatga caaggcacaa   3240

atactttcag aattgtattt cagttttgaa gatttaaaaa aaatgtgaaa ataaatatat   3300

attagtatcc tttattttaa agtcaattgt aaaccagaag tactgttatt ttggtgatta   3360

aaatccaaaa ctttagctgt atttcagtaa caaaaacata ccttactaga ctgtgatggc   3420

tcacacctgt aatcccagtg ctttgggagg ctgaggtggg aagattcttt gagcccagga   3480

gttcaaggct gcagtgaatt ctgatcgcac cactgaactc cagcccgtat gacagagtga   3540

gaccctgttt ctaaaaacaa aacaaacaaa caaacaaaca acgtatctta ctgactaaac   3600

tggaatggaa atcttataat tagtgttgta tttttctgca aaatagtgaa ttggtacttg   3660

ggagacttct gttctttgtt gaaaaaaatt gcctttgttt tgaaattata tcacctgtgt   3720

tctgaactaa aatgatggga gttcattttg tatttacttt gcagtaagta tcatgtaaat   3780

atgcaaatgt tgaatgtaat atagattgtg tcctcattga gtttttgggt gatacagttt   3840

ataaatataa caattataca ccctcataca ttcgtctgat tttgagcttg taagatgaga   3900

actgcttttt acacatttaa taaaaaaagg tctctgaatt aaaaaaaaaa aaaaaaaaa    3959


<210>  3237
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  3237

Met Ser Val Pro Gly Pro Ser Ser Pro Asp Gly Ala Leu Thr Arg Pro 
1               5                   10                  15      


Pro Tyr Cys Leu Glu Ala Gly Glu Pro Thr Pro Gly Leu Ser Asp Thr 
            20                  25                  30          


Ser Pro Asp Glu Gly Leu Ile Glu Asp Leu Thr Ile Glu Asp Lys Ala 
        35                  40                  45              


Val Glu Gln Leu Ala Glu Gly Leu Leu Ser His Tyr Leu Pro Asp Leu 
    50                  55                  60                  


Gln Arg Ser Lys Gln Ala Leu Gln Glu Leu Thr Gln Asn Gln Val Val 
65                  70                  75                  80  


Leu Leu Asp Thr Leu Glu Gln Glu Ile Ser Lys Phe Lys Glu Cys His 
                85                  90                  95      


Ser Met Leu Asp Ile Asn Ala Leu Phe Ala Glu Ala Lys His Tyr His 
            100                 105                 110         


Ala Lys Leu Val Asn Ile Arg Lys Glu Met Leu Met Leu His Glu Lys 
        115                 120                 125             


Thr Ser Lys Leu Lys Lys Arg Ala Leu Lys Leu Gln Gln Lys Arg Gln 
    130                 135                 140                 


Lys Glu Glu Leu Glu Arg Glu Gln Gln Arg Glu Lys Glu Phe Glu Arg 
145                 150                 155                 160 


Glu Lys Gln Leu Thr Ala Arg Pro Ala Lys Arg Met 
                165                 170         


<210>  3238
<211>  1682
<212>  DNA
<213>  Homosapiens

<400>  3238
gaaggttttt gctgcgccaa cgcagtgacc gaaggctccg ctcacgcccg gcctgatcct     60

gcctgaagat ggtgccactg gtggctgtgg tatcagggcc ccgtgcccag ctctttgcct    120

gcctgctcag gctgggcact cagcaggtcg gcccccttca gctgcacacc ggggccagcc    180

atgcggccag gaaccattat gaggtgctgg tgctgggtgg gggcagtggc ggaatcacca    240

tggctgcccg catgaagagg aaagtgggtg cagagaatgt ggccattgtt gagcccagtg    300

agagacattt ctaccagcca atctggacac tggtgggtgc tggtgccaaa caattgtcct    360

catctggtcg tcccacggca agtgtgattc catctggtgt agaatggatc aaagctagag    420

tgactgagtt gaacccagac aagaactgca ttcacacaga tgacgacgag aagatctcct    480

accgatatct tattattgct ctcggaatcc agctggacta tgagaagatt aaaggcctac    540

ctgaaggttt cgctcatccc aaaatagggt cgaattattc agttaagact gtagagaaga    600

catggaaagc tctgcaggac ttcaaagagg gcaatgccat cttcaccttc ccaaatactc    660

cagtgaagtg tgctggagcc cctcagaaga tcatgtactt atcagaagcc tacttcagga    720

agacagggaa gcgatccaag gccaatatca ttttcaacac ttctcttgga gccattttcg    780

gggttaagaa gtatgcagat gccctgcagg agatcatcca ggagcggaac ctcactgtta    840

actacaagaa aaacctcatt gaagtccgag ccgataaaca agaggctgta tttgagaacc    900

tggacaaacc aggagagacc caagtgattt catatgaaat gcttcatgtc acacctccaa    960

tgagcccacc agatgtcctc aagaccagtc ctgtggctga tgctgctggt tgggtggatg   1020

tggataaaga aactctgcaa cacaggaggt acccaaatgt gtttgggatt ggggactgca   1080

ccaaccttcc tacgtcaaag accgctgctg cagtagctgc ccagtcagga atacttgata   1140

ggacaatttc tgtaattatg aagaatcaaa caccaacaaa gaagtatgat ggctacacat   1200

catgtccact ggtgaccggc tacaaccgtg tgattcttgc tgagtttgac tacaaagcag   1260

agccgctaga aaccttcccc tttgatcaaa gcaaagagcg cctttccatg tatctcatga   1320

aagctgacct gatgcctttc ctgtattgga atatgatgct aaggggttac tggggaggac   1380

cagcgtttct gcgcaagttg tttcatctag gtatgagtta aggatggctc agcacttgct   1440

catcttggat ggcttctggg ccaaaactgc agtcactgaa tgaccaagag cagcacgaag   1500

gacttggaac ctatccttgt aaagagttcc ttgatgggta atggtgacca aatgcctccc   1560

ttttcagtac ctttgaacag caaccatgtg ggctactcat gatgggcttg attctttggg   1620

aataataaaa tgaaataata cttttatttt ctgaataaaa gtttgtcact gaaaaaaaaa   1680

aa                                                                  1682


<210>  3239
<211>  450
<212>  PRT
<213>  Homosapiens

<400>  3239

Met Val Pro Leu Val Ala Val Val Ser Gly Pro Arg Ala Gln Leu Phe 
1               5                   10                  15      


Ala Cys Leu Leu Arg Leu Gly Thr Gln Gln Val Gly Pro Leu Gln Leu 
            20                  25                  30          


His Thr Gly Ala Ser His Ala Ala Arg Asn His Tyr Glu Val Leu Val 
        35                  40                  45              


Leu Gly Gly Gly Ser Gly Gly Ile Thr Met Ala Ala Arg Met Lys Arg 
    50                  55                  60                  


Lys Val Gly Ala Glu Asn Val Ala Ile Val Glu Pro Ser Glu Arg His 
65                  70                  75                  80  


Phe Tyr Gln Pro Ile Trp Thr Leu Val Gly Ala Gly Ala Lys Gln Leu 
                85                  90                  95      


Ser Ser Ser Gly Arg Pro Thr Ala Ser Val Ile Pro Ser Gly Val Glu 
            100                 105                 110         


Trp Ile Lys Ala Arg Val Thr Glu Leu Asn Pro Asp Lys Asn Cys Ile 
        115                 120                 125             


His Thr Asp Asp Asp Glu Lys Ile Ser Tyr Arg Tyr Leu Ile Ile Ala 
    130                 135                 140                 


Leu Gly Ile Gln Leu Asp Tyr Glu Lys Ile Lys Gly Leu Pro Glu Gly 
145                 150                 155                 160 


Phe Ala His Pro Lys Ile Gly Ser Asn Tyr Ser Val Lys Thr Val Glu 
                165                 170                 175     


Lys Thr Trp Lys Ala Leu Gln Asp Phe Lys Glu Gly Asn Ala Ile Phe 
            180                 185                 190         


Thr Phe Pro Asn Thr Pro Val Lys Cys Ala Gly Ala Pro Gln Lys Ile 
        195                 200                 205             


Met Tyr Leu Ser Glu Ala Tyr Phe Arg Lys Thr Gly Lys Arg Ser Lys 
    210                 215                 220                 


Ala Asn Ile Ile Phe Asn Thr Ser Leu Gly Ala Ile Phe Gly Val Lys 
225                 230                 235                 240 


Lys Tyr Ala Asp Ala Leu Gln Glu Ile Ile Gln Glu Arg Asn Leu Thr 
                245                 250                 255     


Val Asn Tyr Lys Lys Asn Leu Ile Glu Val Arg Ala Asp Lys Gln Glu 
            260                 265                 270         


Ala Val Phe Glu Asn Leu Asp Lys Pro Gly Glu Thr Gln Val Ile Ser 
        275                 280                 285             


Tyr Glu Met Leu His Val Thr Pro Pro Met Ser Pro Pro Asp Val Leu 
    290                 295                 300                 


Lys Thr Ser Pro Val Ala Asp Ala Ala Gly Trp Val Asp Val Asp Lys 
305                 310                 315                 320 


Glu Thr Leu Gln His Arg Arg Tyr Pro Asn Val Phe Gly Ile Gly Asp 
                325                 330                 335     


Cys Thr Asn Leu Pro Thr Ser Lys Thr Ala Ala Ala Val Ala Ala Gln 
            340                 345                 350         


Ser Gly Ile Leu Asp Arg Thr Ile Ser Val Ile Met Lys Asn Gln Thr 
        355                 360                 365             


Pro Thr Lys Lys Tyr Asp Gly Tyr Thr Ser Cys Pro Leu Val Thr Gly 
    370                 375                 380                 


Tyr Asn Arg Val Ile Leu Ala Glu Phe Asp Tyr Lys Ala Glu Pro Leu 
385                 390                 395                 400 


Glu Thr Phe Pro Phe Asp Gln Ser Lys Glu Arg Leu Ser Met Tyr Leu 
                405                 410                 415     


Met Lys Ala Asp Leu Met Pro Phe Leu Tyr Trp Asn Met Met Leu Arg 
            420                 425                 430         


Gly Tyr Trp Gly Gly Pro Ala Phe Leu Arg Lys Leu Phe His Leu Gly 
        435                 440                 445             


Met Ser 
    450 


<210>  3240
<211>  7024
<212>  DNA
<213>  Homosapiens

<400>  3240
gtggactgca ttttgcaaga agttgagaag tttacagacc tagagaaact ctacctctac     60

cttcagctgc cttctggtct cagcaatgga gagaaaagtg atcagaatgc catgtcatct    120

agtcgggcac aacaaatgca tgccttttcc tggattcgga ataccctaga ggaacatccg    180

gagacttcac tgcccaaaca ggaagtctat gatgagtaca agagctattg tgacaatctt    240

ggttaccatc cattaagtgc tgctgatttt ggaaagatca tgaaaaacgt ctttccaaac    300

atgaaggcac gtcgtttggg cacaagaggc aaatctaaat attgctacag tggactaaga    360

aaaaaagctt ttgttcatat gccaacactg cccaaccttg actttcacaa aactggagat    420

gggttggaag gagctgaacc ttctgggcag cttcaaaata ttgatgaaga agttatctct    480

tctgcttgcc gtcttgtgtg tgagtgggcc cagaaagtgt taagccaacc atttgacacc    540

gtcttggaat tagcccgctt ccttgtaaaa agtcactata taggcaccaa gtcaatggca    600

gctctaactg taatggcagc agcaccagca ggaatgaaag gaattaccca gccttctgct    660

tttataccta cagctgaaag taattccttt cagcctcagg tgaagacttt gccatctcca    720

attgatgcta aacagcagtt gcaacggaaa atccagaaga agcagcaaga acagaaacta    780

caatcccctt tgccaggaga atctgcagca aaaaagtcag aaagtgctac aagcaatgga    840

gtgactaatc ttcctaatgg aaatccttca atcctttctc ctcaacctat tggtatcgtt    900

gtggcagctg tccctagtcc cattccggtc cagcggacta ggcaattggt aacttcaccg    960

agtccaatga gttcttctga cggcaaagtt cttcccctca atgtacaggt ggtcactcag   1020

cacatgcagt ctgtgaaaca ggcaccaaag actccccaga acgttccagc cagtcctggt   1080

ggggatcgtt ctgcccggca ccgttaccct cagatcttac ccaaaccagc gaacaccagt   1140

gcactcacca ttcgctctcc aactactgtc ctctttacta gtagtcccat caaaactgct   1200

gttgtacccg cttcacacat gagttctcta aatgtggtga aaatgacaac aatatccctc   1260

acacccagca acagtaacac ccctcttaaa cattctgcct cagtcagcag tgctacagga   1320

acaacagaag aatcaaggag tgttccacag atcaagaatg gttctgtcgt gtcgcttcag   1380

tctcctgggt ccaggagcag cagtgcgggg ggaacatctg ctgtggaagt caaagtggaa   1440

cccgaaacat catcagatga gcatcctgta cagtgccaag agaactctga tgaggctaaa   1500

gctccccaga cacctagtgc ccttttgggg cagaaaagta atacagacgg agcactgcag   1560

aaaccttcaa atgaaggtgt cattgaaata aaagcaacta aggtctgtga ccagaggacc   1620

aaatgtaaaa gtcgctgtaa tgaaatgctg ccaggcacgt caacaggcaa taatcaaagc   1680

actatcactc tatcagttgc ttctcagaac ttgactttca ccagcagcag ctcaccacct   1740

aatggtgact caatcaataa agaccctaaa ttatgcacta aaagcccaag aaaacgactg   1800

tcttctacat tgcaagagac ccaggtgcct cctgtaaaga aaccaattgt ggaacagctt   1860

tcagcagcta ccatagaagg gcagaaacaa ggcagtgtta agaaggacca aaaggttcca   1920

cattcaggga aaacagaagg ttcaacagca ggtgctcaga ttcctagcaa ggtatcagta   1980

aatgtcagtt cacacatagg agcaaatcaa cccttgaatt cctctgccct tgttatcagt   2040

gattcagctt tggaacagca aacaacccca tcatcatctc cagatataaa agtaaaactt   2100

gaaggaagtg tctttctctt ggacagtgat tcaaagtcag ttggcagctt taatccaaat   2160

ggatggcaac aaatcactaa agattctgag tttatatctg ccagttgtga acaacagcaa   2220

gatatcagtg ttatgacaat tcctgagcac tctgatatca atgacttaga gaaatctgtt   2280

tgggaattag aaggaatgcc acaggacaca tatagccagc agctacatag ccagatacag   2340

gaatcttctt taaatcaaat acaagcacat tcttcagatc agttacctct gcaatctgaa   2400

ctgaaggagt ttgagccttc tgtttcccag acaaatgaaa gctactttcc ttttgatgat   2460

gaacttacac aagatagtat tgtggaagag ctggtgctta tggagcagca aatgtcaatg   2520

aacaattctc attcttacgg caactgtttg ggaatgaccc ttcagagtca gtcagtaact   2580

ccaggagctc caatgtcatc tcacacttcc agcacccact tctatcatcc aatccacagc   2640

aatggcactc caatccacac acccacaccc acacccacac ccactcctac tccaacccca   2700

accccaaccc cgacatctga aatgattgct ggatctcaga gtctgtcacg ggagagccct   2760

tgctccaggc tagcccagac tacacctgtg gatagtgctt taggaagtag ccgacataca   2820

cccattggta ctccacattc taactgcagc agtagtgtcc cccccagccc tgttgaatgc   2880

aggaatccgt ttgcattcac tccaataagc tccagtatgg catatcatga cgccagcatt   2940

gtctcaagta gtcctgtgaa accgatgcaa agacccatgg ccacacaccc tgacaaaacc   3000

aagcttgaat ggatgaataa tgggtatagt ggggttggta attcatcagt ttctggccat   3060

ggtattctcc caagctatca ggaactagtg gaagaccgtt tcaggaaacc tcatgctttt   3120

gctgtgcctg gacagtctta tcagtctcaa tccagacatc atgacactca ttttggtcgt   3180

ttgactcctg tctctcctgt gcagcatcaa ggtgccactg taaataacac caacaaacag   3240

gagggttttg cagtccctgc ccctcttgat aataaaggaa ctaattcatc tgccagcagc   3300

aacttcagat gccggagtgt gagccctgct gttcatcgcc aacgtaatct tagtggaagc   3360

accctctatc cagtatctaa tatcccacga tctaatgtga ccccctttgg aagtccagtt   3420

accccagaag ttcatgtttt cacaaatgtt cacacagacg catgtgccaa caacatagct   3480

caaagaagcc aatcagttcc attgacagtc atgatgcaga cagccttccc aaacgctctt   3540

cagaagcaag caaacagtaa aaaaataacc aatgttttgt tgagtaaact tgattccgac   3600

aatgatgatg cagtgagagg tttgggaatg aacaacctgc cctctaatta tacagcccgg   3660

atgaatctca ctcagatttt ggaaccttcc actgtttttc ctagtgccaa cccacaaaat   3720

atgatcgatt ccagcacttc tgtttatgag ttccaaacac catcttacct caccaaaagt   3780

aatagcaccg gtcagatcaa tttttctcct ggagataatc aagcacaatc agaaattgga   3840

gagcaacaat tagatttcaa tagcactgtt aaagacctgt tgagtggaga cagcttgcaa   3900

accaaccagc agctggtagg tcagggagca tctgatctca ctaatactgc atctgatttc   3960

tctagcgata tcaggttgtc ttctgagctc tcaggcagca tcaatgattt gaacacttta   4020

gacccaaatc tactgtttga tccaggtcgt cagcagggac aagatgatga agctacactg   4080

gaagaattaa agaatgaccc attatttcaa caaatttgca gtgaatccat gaattctatg   4140

acttcatcag gttttgaatg gatagaaagc aaggaccatc ctactgttga aatgttgggt   4200

taaattgtgt tttataacat gtagcacact gtatctaaag acatatgtat tgtatttgtc   4260

ttaatggaag tgcctcccgc agcagaaata ctattaattg tgacatttta aaagcgtttg   4320

ctgcagaagt ggtttcttca gtaggaaatg gttagacttg cctcagttct taacaagtgt   4380

ctaaagacag taggctgtag aagaacaagt attaggtttt aaattttata atgtgcccca   4440

tttattcaca ttgattgact atccagctgt tacaagagca gtcgatcttt attttgtgta   4500

agttagtttc atttcatcag atgatctgca cagaactcag aataaaccat caattttagg   4560

tataggctgt tttgttgttg gcattatctt ttagatataa aatcatagct agggtgaact   4620

gtagacaaga aagtcttcct tgaaacaggg ataatattca ggttattata aatatttagg   4680

cttgaagcat agagctactg tagggtgaaa aatctctgta ggactttctg gggcttcagt   4740

accatttaca cccacgatga agggcttaaa tagaaaataa tggaaaatta aatattactt   4800

taaggaaagc aaagctgcac taaaattttt aagggaaaaa aaacaagtag ccatttatat   4860

ttgtgacctt gcattaatat ttaaatgttg attttaatat ggagctagca cacatagatg   4920

cgcaggcacg cacacacaaa acaagcaaat gtaactccag gcatttgtaa tttaatataa   4980

taaatacaag catgttagaa aaatgcttta tgtcttatta tttgttaagt taggggaatg   5040

agaaggaaaa caaaagcatt ctcttagttt catcacaatg gctgcatgta catattgaga   5100

ttctaattga gatttacttt gaaatttttc attaaaatat tccacaataa tcagtttttt   5160

tcctcttcaa ttgagtgact gactccctca ctcctcctga atatagtaat gtagtttgat   5220

cataggatcc ctttgaaaaa caggaaggag gataacataa aaaacaacaa aaaacatttc   5280

accacctaag gtctgaagcc acaaatcttt atatctctga tgaaacaaag gggatatcaa   5340

tagtacttga agaagaagag cattttatta cttgcttaat ttatttattg tgataaccac   5400

aattgcaaaa gaagaactca ggatttgttt taaaatgttt ctctctatgg ctcccatttt   5460

gttttgtgaa taattattta tgagttgcat gttgacacaa acctactcac tggttgaaag   5520

ctccatttaa gtgagtttca agatcacttt caaagagatt tttaaattgc cattgttttt   5580

aaagctaaca taaaaccatt tgctatgcta ccttgaacct agctaagctt tcctttacct   5640

tagtaagcca atcagaagac tacaatcaat gaatatttag caaatgtgct gaagggttta   5700

ataaggtttt gttgttcaat aaatttgcaa ggtagggtat taacatattt tgataaataa   5760

atggtgctag agttggcgca gaggtttata tattgatatg tcttagttat tggcatttgt   5820

gtgtgtttgc tgttatcttg atttcatgat ttgttaggta tttttttctt gatgctagtt   5880

atttcttcac tgtacattga gacacagcac tactgcacac caaagtatgc aatacccaaa   5940

ggaaactctg tgatttctcc tgacaaatga tgggagcctt tctttatgag atactctgaa   6000

aaggagattt tgaggccatt ctaatccctt gtttacatta ttagcttcct actaatataa   6060

aaataatgga aatctttttt gataaaaata ttaagactgg aggattttta accccttgta   6120

cagtattgca gcaaactctt taaatttggt tgaattcgtc cagcaaactt tctggggttc   6180

atatattgca ctaaatttgt tgaacctgtg gtaggcacat ctcttaggat aaatgcaacc   6240

aatacagtcc acagattaaa ctttttaaat gtgtttcatt atgaaaagac aaaatgtcat   6300

caaagtgaca gataaaattg tcttatgtag caatgtgcat tgatctcaat gagatatttc   6360

tattattctc ttacatgaga atattacagc aggaagaatt aagtttagtt tgcttcacca   6420

tgttaataca tgatcacaaa atgtgcatga gtgttattga cttatcttgt acagtactag   6480

gattcctgta accactcttt tttttcttcg ctgtattgaa actggttcag tgttaaccag   6540

gcaagcatag ttattcacag gttatttact ttatgtttac taattctgct tagttattgt   6600

tgaatatgtt ctgttccaga ttatttttat tgttttgatg tttaaaacat tttgcatact   6660

gtttatcata aaacttcatg aagtaaataa ttttgcatat aattgcaata agcactgact   6720

tttgaactga aaagaaggaa agtgtttttt tgtgcagtgc ttctgaggtt catataatag   6780

tcttgtacta taatgtgctt tactacacga taaatgacaa aaacaagccc tgtttcatgt   6840

ttcatttagt gcaaaaagtc agatttcccc agtgttttgt tgtctgttgt acctgctgaa   6900

actacagtag ttgaatattg cggtagcatt tcagttctct ttttttatta aagtgctcaa   6960

aaattgtttt ttaaatgttt tcaaaaacaa ttaaaaacat tttatattaa aaaaaaaaaa   7020

aaaa                                                                7024


<210>  3241
<211>  1363
<212>  PRT
<213>  Homosapiens

<400>  3241

Met Ser Ser Ser Arg Ala Gln Gln Met His Ala Phe Ser Trp Ile Arg 
1               5                   10                  15      


Asn Thr Leu Glu Glu His Pro Glu Thr Ser Leu Pro Lys Gln Glu Val 
            20                  25                  30          


Tyr Asp Glu Tyr Lys Ser Tyr Cys Asp Asn Leu Gly Tyr His Pro Leu 
        35                  40                  45              


Ser Ala Ala Asp Phe Gly Lys Ile Met Lys Asn Val Phe Pro Asn Met 
    50                  55                  60                  


Lys Ala Arg Arg Leu Gly Thr Arg Gly Lys Ser Lys Tyr Cys Tyr Ser 
65                  70                  75                  80  


Gly Leu Arg Lys Lys Ala Phe Val His Met Pro Thr Leu Pro Asn Leu 
                85                  90                  95      


Asp Phe His Lys Thr Gly Asp Gly Leu Glu Gly Ala Glu Pro Ser Gly 
            100                 105                 110         


Gln Leu Gln Asn Ile Asp Glu Glu Val Ile Ser Ser Ala Cys Arg Leu 
        115                 120                 125             


Val Cys Glu Trp Ala Gln Lys Val Leu Ser Gln Pro Phe Asp Thr Val 
    130                 135                 140                 


Leu Glu Leu Ala Arg Phe Leu Val Lys Ser His Tyr Ile Gly Thr Lys 
145                 150                 155                 160 


Ser Met Ala Ala Leu Thr Val Met Ala Ala Ala Pro Ala Gly Met Lys 
                165                 170                 175     


Gly Ile Thr Gln Pro Ser Ala Phe Ile Pro Thr Ala Glu Ser Asn Ser 
            180                 185                 190         


Phe Gln Pro Gln Val Lys Thr Leu Pro Ser Pro Ile Asp Ala Lys Gln 
        195                 200                 205             


Gln Leu Gln Arg Lys Ile Gln Lys Lys Gln Gln Glu Gln Lys Leu Gln 
    210                 215                 220                 


Ser Pro Leu Pro Gly Glu Ser Ala Ala Lys Lys Ser Glu Ser Ala Thr 
225                 230                 235                 240 


Ser Asn Gly Val Thr Asn Leu Pro Asn Gly Asn Pro Ser Ile Leu Ser 
                245                 250                 255     


Pro Gln Pro Ile Gly Ile Val Val Ala Ala Val Pro Ser Pro Ile Pro 
            260                 265                 270         


Val Gln Arg Thr Arg Gln Leu Val Thr Ser Pro Ser Pro Met Ser Ser 
        275                 280                 285             


Ser Asp Gly Lys Val Leu Pro Leu Asn Val Gln Val Val Thr Gln His 
    290                 295                 300                 


Met Gln Ser Val Lys Gln Ala Pro Lys Thr Pro Gln Asn Val Pro Ala 
305                 310                 315                 320 


Ser Pro Gly Gly Asp Arg Ser Ala Arg His Arg Tyr Pro Gln Ile Leu 
                325                 330                 335     


Pro Lys Pro Ala Asn Thr Ser Ala Leu Thr Ile Arg Ser Pro Thr Thr 
            340                 345                 350         


Val Leu Phe Thr Ser Ser Pro Ile Lys Thr Ala Val Val Pro Ala Ser 
        355                 360                 365             


His Met Ser Ser Leu Asn Val Val Lys Met Thr Thr Ile Ser Leu Thr 
    370                 375                 380                 


Pro Ser Asn Ser Asn Thr Pro Leu Lys His Ser Ala Ser Val Ser Ser 
385                 390                 395                 400 


Ala Thr Gly Thr Thr Glu Glu Ser Arg Ser Val Pro Gln Ile Lys Asn 
                405                 410                 415     


Gly Ser Val Val Ser Leu Gln Ser Pro Gly Ser Arg Ser Ser Ser Ala 
            420                 425                 430         


Gly Gly Thr Ser Ala Val Glu Val Lys Val Glu Pro Glu Thr Ser Ser 
        435                 440                 445             


Asp Glu His Pro Val Gln Cys Gln Glu Asn Ser Asp Glu Ala Lys Ala 
    450                 455                 460                 


Pro Gln Thr Pro Ser Ala Leu Leu Gly Gln Lys Ser Asn Thr Asp Gly 
465                 470                 475                 480 


Ala Leu Gln Lys Pro Ser Asn Glu Gly Val Ile Glu Ile Lys Ala Thr 
                485                 490                 495     


Lys Val Cys Asp Gln Arg Thr Lys Cys Lys Ser Arg Cys Asn Glu Met 
            500                 505                 510         


Leu Pro Gly Thr Ser Thr Gly Asn Asn Gln Ser Thr Ile Thr Leu Ser 
        515                 520                 525             


Val Ala Ser Gln Asn Leu Thr Phe Thr Ser Ser Ser Ser Pro Pro Asn 
    530                 535                 540                 


Gly Asp Ser Ile Asn Lys Asp Pro Lys Leu Cys Thr Lys Ser Pro Arg 
545                 550                 555                 560 


Lys Arg Leu Ser Ser Thr Leu Gln Glu Thr Gln Val Pro Pro Val Lys 
                565                 570                 575     


Lys Pro Ile Val Glu Gln Leu Ser Ala Ala Thr Ile Glu Gly Gln Lys 
            580                 585                 590         


Gln Gly Ser Val Lys Lys Asp Gln Lys Val Pro His Ser Gly Lys Thr 
        595                 600                 605             


Glu Gly Ser Thr Ala Gly Ala Gln Ile Pro Ser Lys Val Ser Val Asn 
    610                 615                 620                 


Val Ser Ser His Ile Gly Ala Asn Gln Pro Leu Asn Ser Ser Ala Leu 
625                 630                 635                 640 


Val Ile Ser Asp Ser Ala Leu Glu Gln Gln Thr Thr Pro Ser Ser Ser 
                645                 650                 655     


Pro Asp Ile Lys Val Lys Leu Glu Gly Ser Val Phe Leu Leu Asp Ser 
            660                 665                 670         


Asp Ser Lys Ser Val Gly Ser Phe Asn Pro Asn Gly Trp Gln Gln Ile 
        675                 680                 685             


Thr Lys Asp Ser Glu Phe Ile Ser Ala Ser Cys Glu Gln Gln Gln Asp 
    690                 695                 700                 


Ile Ser Val Met Thr Ile Pro Glu His Ser Asp Ile Asn Asp Leu Glu 
705                 710                 715                 720 


Lys Ser Val Trp Glu Leu Glu Gly Met Pro Gln Asp Thr Tyr Ser Gln 
                725                 730                 735     


Gln Leu His Ser Gln Ile Gln Glu Ser Ser Leu Asn Gln Ile Gln Ala 
            740                 745                 750         


His Ser Ser Asp Gln Leu Pro Leu Gln Ser Glu Leu Lys Glu Phe Glu 
        755                 760                 765             


Pro Ser Val Ser Gln Thr Asn Glu Ser Tyr Phe Pro Phe Asp Asp Glu 
    770                 775                 780                 


Leu Thr Gln Asp Ser Ile Val Glu Glu Leu Val Leu Met Glu Gln Gln 
785                 790                 795                 800 


Met Ser Met Asn Asn Ser His Ser Tyr Gly Asn Cys Leu Gly Met Thr 
                805                 810                 815     


Leu Gln Ser Gln Ser Val Thr Pro Gly Ala Pro Met Ser Ser His Thr 
            820                 825                 830         


Ser Ser Thr His Phe Tyr His Pro Ile His Ser Asn Gly Thr Pro Ile 
        835                 840                 845             


His Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr 
    850                 855                 860                 


Pro Thr Pro Thr Ser Glu Met Ile Ala Gly Ser Gln Ser Leu Ser Arg 
865                 870                 875                 880 


Glu Ser Pro Cys Ser Arg Leu Ala Gln Thr Thr Pro Val Asp Ser Ala 
                885                 890                 895     


Leu Gly Ser Ser Arg His Thr Pro Ile Gly Thr Pro His Ser Asn Cys 
            900                 905                 910         


Ser Ser Ser Val Pro Pro Ser Pro Val Glu Cys Arg Asn Pro Phe Ala 
        915                 920                 925             


Phe Thr Pro Ile Ser Ser Ser Met Ala Tyr His Asp Ala Ser Ile Val 
    930                 935                 940                 


Ser Ser Ser Pro Val Lys Pro Met Gln Arg Pro Met Ala Thr His Pro 
945                 950                 955                 960 


Asp Lys Thr Lys Leu Glu Trp Met Asn Asn Gly Tyr Ser Gly Val Gly 
                965                 970                 975     


Asn Ser Ser Val Ser Gly His Gly Ile Leu Pro Ser Tyr Gln Glu Leu 
            980                 985                 990         


Val Glu Asp Arg Phe Arg Lys Pro  His Ala Phe Ala Val  Pro Gly Gln 
        995                 1000                 1005             


Ser Tyr  Gln Ser Gln Ser Arg  His His Asp Thr His  Phe Gly Arg 
    1010                 1015                 1020             


Leu Thr  Pro Val Ser Pro Val  Gln His Gln Gly Ala  Thr Val Asn 
    1025                 1030                 1035             


Asn Thr  Asn Lys Gln Glu Gly  Phe Ala Val Pro Ala  Pro Leu Asp 
    1040                 1045                 1050             


Asn Lys  Gly Thr Asn Ser Ser  Ala Ser Ser Asn Phe  Arg Cys Arg 
    1055                 1060                 1065             


Ser Val  Ser Pro Ala Val His  Arg Gln Arg Asn Leu  Ser Gly Ser 
    1070                 1075                 1080             


Thr Leu  Tyr Pro Val Ser Asn  Ile Pro Arg Ser Asn  Val Thr Pro 
    1085                 1090                 1095             


Phe Gly  Ser Pro Val Thr Pro  Glu Val His Val Phe  Thr Asn Val 
    1100                 1105                 1110             


His Thr  Asp Ala Cys Ala Asn  Asn Ile Ala Gln Arg  Ser Gln Ser 
    1115                 1120                 1125             


Val Pro  Leu Thr Val Met Met  Gln Thr Ala Phe Pro  Asn Ala Leu 
    1130                 1135                 1140             


Gln Lys  Gln Ala Asn Ser Lys  Lys Ile Thr Asn Val  Leu Leu Ser 
    1145                 1150                 1155             


Lys Leu  Asp Ser Asp Asn Asp  Asp Ala Val Arg Gly  Leu Gly Met 
    1160                 1165                 1170             


Asn Asn  Leu Pro Ser Asn Tyr  Thr Ala Arg Met Asn  Leu Thr Gln 
    1175                 1180                 1185             


Ile Leu  Glu Pro Ser Thr Val  Phe Pro Ser Ala Asn  Pro Gln Asn 
    1190                 1195                 1200             


Met Ile  Asp Ser Ser Thr Ser  Val Tyr Glu Phe Gln  Thr Pro Ser 
    1205                 1210                 1215             


Tyr Leu  Thr Lys Ser Asn Ser  Thr Gly Gln Ile Asn  Phe Ser Pro 
    1220                 1225                 1230             


Gly Asp  Asn Gln Ala Gln Ser  Glu Ile Gly Glu Gln  Gln Leu Asp 
    1235                 1240                 1245             


Phe Asn  Ser Thr Val Lys Asp  Leu Leu Ser Gly Asp  Ser Leu Gln 
    1250                 1255                 1260             


Thr Asn  Gln Gln Leu Val Gly  Gln Gly Ala Ser Asp  Leu Thr Asn 
    1265                 1270                 1275             


Thr Ala  Ser Asp Phe Ser Ser  Asp Ile Arg Leu Ser  Ser Glu Leu 
    1280                 1285                 1290             


Ser Gly  Ser Ile Asn Asp Leu  Asn Thr Leu Asp Pro  Asn Leu Leu 
    1295                 1300                 1305             


Phe Asp  Pro Gly Arg Gln Gln  Gly Gln Asp Asp Glu  Ala Thr Leu 
    1310                 1315                 1320             


Glu Glu  Leu Lys Asn Asp Pro  Leu Phe Gln Gln Ile  Cys Ser Glu 
    1325                 1330                 1335             


Ser Met  Asn Ser Met Thr Ser  Ser Gly Phe Glu Trp  Ile Glu Ser 
    1340                 1345                 1350             


Lys Asp  His Pro Thr Val Glu  Met Leu Gly 
    1355                 1360             


<210>  3242
<211>  1470
<212>  DNA
<213>  Homosapiens

<400>  3242
cgaagatggc ggggcgaagt ctgtgtctca cgagaagcag cgttccaggg actccgttcc     60

cgccacccgt tcagcaaccc tctacacctg gacccgacct cctcgccttg gaggaagaat    120

ataagcgttt aaatgcagaa ttgcaggcaa aaacagctga cgtggttcaa caagctaagg    180

aaataataag agatcggcaa gaagtacgat ctaggcctgt ttcaacacaa atgaaatcat    240

gtgatgacga agatgattac agtttaagag gtctgttacc atctgaaggg atagttcatc    300

ttcattcaga aactaagcca aagaccaaaa acattgatcc tgtaaacaag gttcaaaaca    360

aattacactc tgcaaataaa ggaaggaaaa caaattcaag tgttaaattg aaatactctg    420

atgtccaaac tgccgacgat gttgccattc cagaggattt ctcagacttt tcccttgcaa    480

aaacaattag caaaattgaa gggcaactgg aggaagaagg cttacctgaa tatatagatg    540

atattttttc tggtgttagt aatgacattg gaacagaagc acagatcaga tttctaaagg    600

ccaaactcca tgttatgcag gaggaattgg ataatgttgt atgtgaatgc aataaaaagg    660

aggatgaaat tcagaattta aagtctcaag taaaaaattt tgaagaagat tttatgagac    720

agcagcgaac aattaatatg caacagtctc aagtagaaaa atacaaaact cttttcgaag    780

aagcaaacaa aaagtatgat ggattacagc aacagttgtc ttcagtagaa agggaattag    840

aaaataaaag aagactgcaa aaacaggctg caagtagtca aagtgccaca gaggttcgct    900

tgaatagagc tctagaagaa gcagaaaagt ataaactgga gttaagtaaa ttaaggcaaa    960

ataacaagga catagcaaat gaagaacaca aaaaaattga agtgttaaaa tcagaaaaca   1020

agaagctaga aaaacaaaaa ggagaattaa tgatagggtt caagaaacag ttaaaattaa   1080

ttgatgtttt aaaaaggcaa aagatgcata ttgaagctgc caagatgcta tctttcactg   1140

aggaggaatt tatgaaagca cttgaatggg gaaattcata agtgatctac ttcagttagt   1200

ctctatgaca ataagaaaac taaggctcag agaaaaagcc aaaactagta cttgcatgac   1260

acctagtcaa gtcctagtag tattcgactt tcattttgtg gatcaatttt tatttggaaa   1320

atagcagcaa ttctcgtagg agtcagatta aaacgtctac aactaccttg aataacttca   1380

actatcagga taattaaaac tgcaaaccac tggaaaaaaa aaaaaaaaaa aaaaaaaaaa   1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                    1470


<210>  3243
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  3243

Met Ala Gly Arg Ser Leu Cys Leu Thr Arg Ser Ser Val Pro Gly Thr 
1               5                   10                  15      


Pro Phe Pro Pro Pro Val Gln Gln Pro Ser Thr Pro Gly Pro Asp Leu 
            20                  25                  30          


Leu Ala Leu Glu Glu Glu Tyr Lys Arg Leu Asn Ala Glu Leu Gln Ala 
        35                  40                  45              


Lys Thr Ala Asp Val Val Gln Gln Ala Lys Glu Ile Ile Arg Asp Arg 
    50                  55                  60                  


Gln Glu Val Arg Ser Arg Pro Val Ser Thr Gln Met Lys Ser Cys Asp 
65                  70                  75                  80  


Asp Glu Asp Asp Tyr Ser Leu Arg Gly Leu Leu Pro Ser Glu Gly Ile 
                85                  90                  95      


Val His Leu His Ser Glu Thr Lys Pro Lys Thr Lys Asn Ile Asp Pro 
            100                 105                 110         


Val Asn Lys Val Gln Asn Lys Leu His Ser Ala Asn Lys Gly Arg Lys 
        115                 120                 125             


Thr Asn Ser Ser Val Lys Leu Lys Tyr Ser Asp Val Gln Thr Ala Asp 
    130                 135                 140                 


Asp Val Ala Ile Pro Glu Asp Phe Ser Asp Phe Ser Leu Ala Lys Thr 
145                 150                 155                 160 


Ile Ser Lys Ile Glu Gly Gln Leu Glu Glu Glu Gly Leu Pro Glu Tyr 
                165                 170                 175     


Ile Asp Asp Ile Phe Ser Gly Val Ser Asn Asp Ile Gly Thr Glu Ala 
            180                 185                 190         


Gln Ile Arg Phe Leu Lys Ala Lys Leu His Val Met Gln Glu Glu Leu 
        195                 200                 205             


Asp Asn Val Val Cys Glu Cys Asn Lys Lys Glu Asp Glu Ile Gln Asn 
    210                 215                 220                 


Leu Lys Ser Gln Val Lys Asn Phe Glu Glu Asp Phe Met Arg Gln Gln 
225                 230                 235                 240 


Arg Thr Ile Asn Met Gln Gln Ser Gln Val Glu Lys Tyr Lys Thr Leu 
                245                 250                 255     


Phe Glu Glu Ala Asn Lys Lys Tyr Asp Gly Leu Gln Gln Gln Leu Ser 
            260                 265                 270         


Ser Val Glu Arg Glu Leu Glu Asn Lys Arg Arg Leu Gln Lys Gln Ala 
        275                 280                 285             


Ala Ser Ser Gln Ser Ala Thr Glu Val Arg Leu Asn Arg Ala Leu Glu 
    290                 295                 300                 


Glu Ala Glu Lys Tyr Lys Leu Glu Leu Ser Lys Leu Arg Gln Asn Asn 
305                 310                 315                 320 


Lys Asp Ile Ala Asn Glu Glu His Lys Lys Ile Glu Val Leu Lys Ser 
                325                 330                 335     


Glu Asn Lys Lys Leu Glu Lys Gln Lys Gly Glu Leu Met Ile Gly Phe 
            340                 345                 350         


Lys Lys Gln Leu Lys Leu Ile Asp Val Leu Lys Arg Gln Lys Met His 
        355                 360                 365             


Ile Glu Ala Ala Lys Met Leu Ser Phe Thr Glu Glu Glu Phe Met Lys 
    370                 375                 380                 


Ala Leu Glu Trp Gly Asn Ser 
385                 390     


<210>  3244
<211>  1945
<212>  DNA
<213>  Homosapiens

<400>  3244
acttttggtc gagcggaggg cgcgcagctc caccgttgcc aagacgccgc gtaaacaccc     60

gagcgcgcgc agccaggtgc gctccttggg gctgctggct gctgcgtttg cggcgggagg    120

tggtggccgc ggtcccacga gaaggggtat ttttcgtcag ccaagatggg ttccaaaagg    180

agaaatttga gctgtagtga aaggcatcag aaattagtag atgaaaacta ctgcaaaaaa    240

ttacatgtcc aagctctaaa aaacgtcaac agtcaaatca ggaatcaaat ggtgcagaat    300

gaaaatgata accgtgttca gcgcaagcaa tttctcagat tattacaaaa tgaacaattt    360

gagttggata tggaagaggc cattcaaaag gcagaagaaa acaagagatt gaaagaactc    420

cagctcaaac aagaagaaaa actggctatg gaattggcaa aactgaaaca tgaaagtcta    480

aaggacgaaa agatgaggca acaagtaaga gaaaacagca ttgagcttag agaattggag    540

aagaaattaa aagcagctta catgaataaa gaaagggcag ctcagattgc tgaaaaggat    600

gccattaaat atgaacaaat gaaacgtgat gctgaaatag ccaaaaccat gatggaagaa    660

cacaagagaa taataaagga agagaatgct gcagaagaca aacgaaacaa agcgaaagca    720

cagtactatc ttgacttaga gaaacaactt gaagaacaag aaaaaaaaaa gcaggaagct    780

tatgagcagc tgctaaaaga gaaactcatg attgatgaaa ttgttaggaa gatctatgaa    840

gaagatcagt tggaaaaaca acaaaagtta gaaaaaatga atgcaatgcg aaggtatata    900

gaagagtttc agaaagagca ggctctctgg agaaaaaaga aacgtgagga gatggaagaa    960

gaaaacagaa aaatcataga gtttgctaac atgcagcagc aaagagaaga agatcggatg   1020

gcaaaagttc aagaaaatga ggagaaaagg ctacagcttc agaatgcgtt gacacagaaa   1080

ttagaagaaa tgctgcggca acgtgaagat ttggaacaag tgcgacaaga attataccag   1140

gaagaacaag ctgaaatata taagagcaag ctaaaagaag aagcagaaaa gaaattgaga   1200

aagcaaaaag agatgaagca agattttgaa gaacaaatgg ccttgaagga attagtgcta   1260

caggctgcaa aagaggaaga ggagaacttt agaaaaacta tgctagctaa atttgctgag   1320

gatgatcgaa tagaattaat gaatgctcag aaacaaagaa tgaagcagct ggaacacagg   1380

agggctgtgg aaaaacttat tgaagagcgt cgccaacaat tccttgcaga caaacaacgt   1440

gaactagaag agtggcagtt gcagcaaagg cggcaaggat ttattaatgc aattattgaa   1500

gaagaaaggc taaaacttct taaagagcat gctacaaact tactaggcta tctccctaaa   1560

ggagtattta aaaaagagga tgatattgat ctgcttggtg aagagttcag gaaagtatat   1620

caacaaagga gtgaaatttg tgaagagaaa tgatatcatc aaaattgggt aaagcataga   1680

ttttttgtat gttaccacta gatgtcagca taacttttgt tttacagctc agtggcatta   1740

ggtatccatt gtctgtttgg attttgtaaa tcatcactga atttcataac ttgtaaacaa   1800

ttatcagata caaattaatt ttaatcaagc tgttattttt gtactgataa tttcaaaatc   1860

cgatttctac aacactacag agcactgttt gcatccccat cctcaagaca gtatatttac   1920

cttgactaat acagaactct acccc                                         1945


<210>  3245
<211>  495
<212>  PRT
<213>  Homosapiens

<400>  3245

Met Gly Ser Lys Arg Arg Asn Leu Ser Cys Ser Glu Arg His Gln Lys 
1               5                   10                  15      


Leu Val Asp Glu Asn Tyr Cys Lys Lys Leu His Val Gln Ala Leu Lys 
            20                  25                  30          


Asn Val Asn Ser Gln Ile Arg Asn Gln Met Val Gln Asn Glu Asn Asp 
        35                  40                  45              


Asn Arg Val Gln Arg Lys Gln Phe Leu Arg Leu Leu Gln Asn Glu Gln 
    50                  55                  60                  


Phe Glu Leu Asp Met Glu Glu Ala Ile Gln Lys Ala Glu Glu Asn Lys 
65                  70                  75                  80  


Arg Leu Lys Glu Leu Gln Leu Lys Gln Glu Glu Lys Leu Ala Met Glu 
                85                  90                  95      


Leu Ala Lys Leu Lys His Glu Ser Leu Lys Asp Glu Lys Met Arg Gln 
            100                 105                 110         


Gln Val Arg Glu Asn Ser Ile Glu Leu Arg Glu Leu Glu Lys Lys Leu 
        115                 120                 125             


Lys Ala Ala Tyr Met Asn Lys Glu Arg Ala Ala Gln Ile Ala Glu Lys 
    130                 135                 140                 


Asp Ala Ile Lys Tyr Glu Gln Met Lys Arg Asp Ala Glu Ile Ala Lys 
145                 150                 155                 160 


Thr Met Met Glu Glu His Lys Arg Ile Ile Lys Glu Glu Asn Ala Ala 
                165                 170                 175     


Glu Asp Lys Arg Asn Lys Ala Lys Ala Gln Tyr Tyr Leu Asp Leu Glu 
            180                 185                 190         


Lys Gln Leu Glu Glu Gln Glu Lys Lys Lys Gln Glu Ala Tyr Glu Gln 
        195                 200                 205             


Leu Leu Lys Glu Lys Leu Met Ile Asp Glu Ile Val Arg Lys Ile Tyr 
    210                 215                 220                 


Glu Glu Asp Gln Leu Glu Lys Gln Gln Lys Leu Glu Lys Met Asn Ala 
225                 230                 235                 240 


Met Arg Arg Tyr Ile Glu Glu Phe Gln Lys Glu Gln Ala Leu Trp Arg 
                245                 250                 255     


Lys Lys Lys Arg Glu Glu Met Glu Glu Glu Asn Arg Lys Ile Ile Glu 
            260                 265                 270         


Phe Ala Asn Met Gln Gln Gln Arg Glu Glu Asp Arg Met Ala Lys Val 
        275                 280                 285             


Gln Glu Asn Glu Glu Lys Arg Leu Gln Leu Gln Asn Ala Leu Thr Gln 
    290                 295                 300                 


Lys Leu Glu Glu Met Leu Arg Gln Arg Glu Asp Leu Glu Gln Val Arg 
305                 310                 315                 320 


Gln Glu Leu Tyr Gln Glu Glu Gln Ala Glu Ile Tyr Lys Ser Lys Leu 
                325                 330                 335     


Lys Glu Glu Ala Glu Lys Lys Leu Arg Lys Gln Lys Glu Met Lys Gln 
            340                 345                 350         


Asp Phe Glu Glu Gln Met Ala Leu Lys Glu Leu Val Leu Gln Ala Ala 
        355                 360                 365             


Lys Glu Glu Glu Glu Asn Phe Arg Lys Thr Met Leu Ala Lys Phe Ala 
    370                 375                 380                 


Glu Asp Asp Arg Ile Glu Leu Met Asn Ala Gln Lys Gln Arg Met Lys 
385                 390                 395                 400 


Gln Leu Glu His Arg Arg Ala Val Glu Lys Leu Ile Glu Glu Arg Arg 
                405                 410                 415     


Gln Gln Phe Leu Ala Asp Lys Gln Arg Glu Leu Glu Glu Trp Gln Leu 
            420                 425                 430         


Gln Gln Arg Arg Gln Gly Phe Ile Asn Ala Ile Ile Glu Glu Glu Arg 
        435                 440                 445             


Leu Lys Leu Leu Lys Glu His Ala Thr Asn Leu Leu Gly Tyr Leu Pro 
    450                 455                 460                 


Lys Gly Val Phe Lys Lys Glu Asp Asp Ile Asp Leu Leu Gly Glu Glu 
465                 470                 475                 480 


Phe Arg Lys Val Tyr Gln Gln Arg Ser Glu Ile Cys Glu Glu Lys 
                485                 490                 495 


<210>  3246
<211>  4415
<212>  DNA
<213>  Homosapiens

<400>  3246
acggctcggc tgccagctcc gcaatgggag ccgccgccgt cgccgcagtg tagtttttcg     60

tgctcctcct tttcctcctc ctctttctcc tcctcctcag ggctccagtc aggccgatcc    120

gctccgctca cggaaggaaa acagaaataa cttgctggct tgtctggagt cacatggtaa    180

ttcaaaaatg gcagaactgt ttatggaatg tgaagaagag gagctggaac catggcagaa    240

gaaagtaaaa gaagttgagg atgacgatga tgatgagcca atctttgttg gcgagatatc    300

aagttcaaaa ccagcaattt caaatatttt gaacagagtt aaccccagct catattcaag    360

gggactaaag aatggtgcac tcagtcgagg tattactgct gcattcaagc ctacaagtca    420

acactacacg aatccaacat caaatccagt gcctgcctca ccaataaatt ttcatcctga    480

gtctagatct tcagatagtt ctgttattgt tcagcctttt tctaaacctg gttatataac    540

aaactcatca cgagttgtgt ctaataagtc atcagagtta ctgtttgact tgacccagga    600

tacaggatta tcacattacc aagggggacc aacactttct atggcaggta tgagtgaaag    660

ttcattttta tcaaaacgtc cttctacttc tgaagtaaat aatgttaatc caaagaagcc    720

taaacccagc gaaagtgttt ctggagcaaa ttcctcagct gtattacctt cagttaaatc    780

tccttcagtg acttcttccc aggctatgct agcaaaaggt acaaatacct catcaaatca    840

gtctaaaaat ggaacacctt ttccaagagc ttgtccaaag tgcaacattc atttcaatct    900

tttggatcct ttgaaaaatc acatgaagta ttgttgtcca gacatgataa ataacttttt    960

gggactggct aaaacagaat tttcaagtac agtaaataaa aacacaacta ttgattcaga   1020

gaaaggaaaa ttgatcatgt tagttaatga cttttattat ggaaaacatg aaggagatgt   1080

ccaggaggaa cagaagactc acacaacctt taaatgcttc agttgcttga aaattctaaa   1140

aaataacatt aggtttatga accacatgaa acaccatttg gaacttgaga agcagagcag   1200

tgagagctgg gaaaaccata ccacctgcca gcactgctac cgtcagtttc ccacaccatt   1260

tcagttgcag tgtcacatcg aaagtacaca tacgccccat gaattttcta ctatttgtaa   1320

aatctgtgaa ttgtcatttg aaacagaaca tgttctttta caacatatga aggacaatca   1380

taaacctggt gaaatgccat atgtctgcca ggtttgtaat tatagatcat catcattttc   1440

tgatgtagaa actcatttta gaacatccca tgaaaacact aagaacttgc tatgcccgtt   1500

ttgcctcaaa gttattaaaa ttgcaacacc atatatgcat cattatatga agcatcagaa   1560

aaaaggaata catcgttgta caaaatgcag gctgcagttt ttgacatgca aggagaaaat   1620

ggatcataag actcaacacc atcgaacatt tataaaacct aaacaactag aaggattgcc   1680

tcctggaaca aaagttacta ttcgagcttc agttggacct ctgcaatcag gagcttcacc   1740

tacaccttcc attagtgcaa gtgcttctac ccttcagctc tcacctccaa ggactaaaaa   1800

tataactgct aaaaatcctg caaaatctaa tacaagtaaa cctaatacag tcaaatccaa   1860

cgcaagtaaa cctaatacaa gtaagcctaa tggaagtaaa tctaaataca aaccaaaaat   1920

ctctaatatg caaaagaaac aaagcacatt ggctagtagc aataaaaaaa gtaaagtcaa   1980

tacagcattg aggaatttaa ggtatcgtcg gggcattcac aaatgcattg agtgttgttc   2040

cgaaataaaa gattttgcaa accactttcc tacgtacgtc cactgtagtt tttgcagata   2100

caacactagc tgtagcaaag cctatgtaaa tcatatgatg agctttcata gtaaccgtcc   2160

aagcaaaagg ttttgtattt ttaagaagca ttcagaaaat ctccggggca ttactctagt   2220

gtgccttaat tgtgatttcc taagtgatgt ttctggctta gataatatgg ctacacactt   2280

aagtcaacat aaaactcata cttgccaagt tgtaatgcag aaagtttctg tttgtatccc   2340

aacttctgag cacctttctg aattaaaaaa agaagctccc gcaaaggaac aagaacctgt   2400

gtctaaggaa attgcaagac ctaacatggc tgaaagagaa acagaaacat caaattctga   2460

aagtaaacaa gataaagctg cttcttcaaa agaaaaaaat ggatgtaatg caaattcatt   2520

tgaaggctca tcaacaacaa aaagtgaaga aagcataaca gtttcagata aggaaaatga   2580

aacctgtctt gcagaccagg aaactggctc aaaaaacatc gtcagttgtg attcaaatat   2640

tggtgcagat aaagtggaaa agaaaaaaca aatacaacac gtttgtcagg aaatggagtt   2700

gaagatgtgc caaagttcag aaaacataat cttatctgat cagattaaag atcacaactc   2760

cagtgaagcc agattttctt caaagaatat taaggatttg cgattagcat cagataatgt   2820

aagcattgat cagtttttga gaaaaagaca tgaacctgaa tctgttagtt ctgatgttag   2880

cgagcaaggc agtattcatt tggaacctct gactccatcc gaggtacttg agtatgaagc   2940

cacagagatt cttcagaaag gtagtggtga tccttcagcc aagactgatg aagtagtgtc   3000

tgatcaaaca gatgacattc ctggaggaaa taaccctagc acaacagagg caacagtaga   3060

cctggaagat gaaaaagaaa gaagttgaaa ttagtcattt taagtttcag tgtaccaacg   3120

ataagggcat ttggaacagt gctatcaggt gagctcagtg gtgctgttgt aggttcagaa   3180

atggaaatat gtaagggagg tcacacatac actttacctg tatgttcaac ctatgttatc   3240

aaacaaatca attcaccaat aatagcatga ttagtaggga ttcccaaaaa gtttttaaaa   3300

acacgaacag gattttaatg ataattaaat ttgcagtgga aaggtctcat ttaatggttt   3360

tcaaggaaat gggatttggt tgctgacatg aattgatgat attagtaata tttataaagc   3420

ctttcaaact tccatcaatc ctaagctaaa aatctttatt acctgtatat ccttttcagt   3480

taactgagag gaagggattt ggaaaccatg tacttttggg gagtaattga ttaaaaacaa   3540

tggctgattg gcattgttaa tgaaggcttt atttgtgagg atgatgctgg taaatggagc   3600

atgcttagag tactaaattg atctaatgag aatttggatg aacataaact taattttgga   3660

tttaatataa cattccagtc agacgcatgt aaacagaata tttgaatctt tgtacctcca   3720

tacaagtgtt agcctgccag gctgtaagct taccttaatt aaactttcag tgaaagtgga   3780

attattaaga tataaattta tatttgtgct ttttgtcagt gtgtaagctg tgtagaaatt   3840

ctttgatgta ttagttgtat taatgtaaag tagaaaccca ttgttgaaac tcctgtagct   3900

attatgcttt taatattgtt ttaatgatct tccttagaaa taggcccata aaaatggtct   3960

ggaagccaaa ccaaagtatg gtataatgta gatattgtaa agcagtaaac tgaaaacatg   4020

tcctggcatg tattcagcca tgtttaagtg acttttctgt aattgtaaaa taaaaacttc   4080

aaatgggacc taaaacagtg atgtaaaaga actggttttg gaaatttagc ctaatttatc   4140

tataagatgg ctgctaaatt gatttttcag ttctttttat catctagaat ataatagata   4200

tagaaatgaa taatatgaag aacagtagtt tgctttgaaa tactaataaa cttttattta   4260

aaatgcttca tttttacttc ttaaaatgtg ctttggattc ttaaattttg tttcactgaa   4320

tgttcaatgt tttaaatggc gattaaaata ctctgctgta tatagtagtt tttgagtaaa   4380

tatttgcaat aaaaatctgc ccccgaataa aaaaa                              4415


<210>  3247
<211>  966
<212>  PRT
<213>  Homosapiens

<400>  3247

Met Ala Glu Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu Pro Trp 
1               5                   10                  15      


Gln Lys Lys Val Lys Glu Val Glu Asp Asp Asp Asp Asp Glu Pro Ile 
            20                  25                  30          


Phe Val Gly Glu Ile Ser Ser Ser Lys Pro Ala Ile Ser Asn Ile Leu 
        35                  40                  45              


Asn Arg Val Asn Pro Ser Ser Tyr Ser Arg Gly Leu Lys Asn Gly Ala 
    50                  55                  60                  


Leu Ser Arg Gly Ile Thr Ala Ala Phe Lys Pro Thr Ser Gln His Tyr 
65                  70                  75                  80  


Thr Asn Pro Thr Ser Asn Pro Val Pro Ala Ser Pro Ile Asn Phe His 
                85                  90                  95      


Pro Glu Ser Arg Ser Ser Asp Ser Ser Val Ile Val Gln Pro Phe Ser 
            100                 105                 110         


Lys Pro Gly Tyr Ile Thr Asn Ser Ser Arg Val Val Ser Asn Lys Ser 
        115                 120                 125             


Ser Glu Leu Leu Phe Asp Leu Thr Gln Asp Thr Gly Leu Ser His Tyr 
    130                 135                 140                 


Gln Gly Gly Pro Thr Leu Ser Met Ala Gly Met Ser Glu Ser Ser Phe 
145                 150                 155                 160 


Leu Ser Lys Arg Pro Ser Thr Ser Glu Val Asn Asn Val Asn Pro Lys 
                165                 170                 175     


Lys Pro Lys Pro Ser Glu Ser Val Ser Gly Ala Asn Ser Ser Ala Val 
            180                 185                 190         


Leu Pro Ser Val Lys Ser Pro Ser Val Thr Ser Ser Gln Ala Met Leu 
        195                 200                 205             


Ala Lys Gly Thr Asn Thr Ser Ser Asn Gln Ser Lys Asn Gly Thr Pro 
    210                 215                 220                 


Phe Pro Arg Ala Cys Pro Lys Cys Asn Ile His Phe Asn Leu Leu Asp 
225                 230                 235                 240 


Pro Leu Lys Asn His Met Lys Tyr Cys Cys Pro Asp Met Ile Asn Asn 
                245                 250                 255     


Phe Leu Gly Leu Ala Lys Thr Glu Phe Ser Ser Thr Val Asn Lys Asn 
            260                 265                 270         


Thr Thr Ile Asp Ser Glu Lys Gly Lys Leu Ile Met Leu Val Asn Asp 
        275                 280                 285             


Phe Tyr Tyr Gly Lys His Glu Gly Asp Val Gln Glu Glu Gln Lys Thr 
    290                 295                 300                 


His Thr Thr Phe Lys Cys Phe Ser Cys Leu Lys Ile Leu Lys Asn Asn 
305                 310                 315                 320 


Ile Arg Phe Met Asn His Met Lys His His Leu Glu Leu Glu Lys Gln 
                325                 330                 335     


Ser Ser Glu Ser Trp Glu Asn His Thr Thr Cys Gln His Cys Tyr Arg 
            340                 345                 350         


Gln Phe Pro Thr Pro Phe Gln Leu Gln Cys His Ile Glu Ser Thr His 
        355                 360                 365             


Thr Pro His Glu Phe Ser Thr Ile Cys Lys Ile Cys Glu Leu Ser Phe 
    370                 375                 380                 


Glu Thr Glu His Val Leu Leu Gln His Met Lys Asp Asn His Lys Pro 
385                 390                 395                 400 


Gly Glu Met Pro Tyr Val Cys Gln Val Cys Asn Tyr Arg Ser Ser Ser 
                405                 410                 415     


Phe Ser Asp Val Glu Thr His Phe Arg Thr Ser His Glu Asn Thr Lys 
            420                 425                 430         


Asn Leu Leu Cys Pro Phe Cys Leu Lys Val Ile Lys Ile Ala Thr Pro 
        435                 440                 445             


Tyr Met His His Tyr Met Lys His Gln Lys Lys Gly Ile His Arg Cys 
    450                 455                 460                 


Thr Lys Cys Arg Leu Gln Phe Leu Thr Cys Lys Glu Lys Met Asp His 
465                 470                 475                 480 


Lys Thr Gln His His Arg Thr Phe Ile Lys Pro Lys Gln Leu Glu Gly 
                485                 490                 495     


Leu Pro Pro Gly Thr Lys Val Thr Ile Arg Ala Ser Val Gly Pro Leu 
            500                 505                 510         


Gln Ser Gly Ala Ser Pro Thr Pro Ser Ile Ser Ala Ser Ala Ser Thr 
        515                 520                 525             


Leu Gln Leu Ser Pro Pro Arg Thr Lys Asn Ile Thr Ala Lys Asn Pro 
    530                 535                 540                 


Ala Lys Ser Asn Thr Ser Lys Pro Asn Thr Val Lys Ser Asn Ala Ser 
545                 550                 555                 560 


Lys Pro Asn Thr Ser Lys Pro Asn Gly Ser Lys Ser Lys Tyr Lys Pro 
                565                 570                 575     


Lys Ile Ser Asn Met Gln Lys Lys Gln Ser Thr Leu Ala Ser Ser Asn 
            580                 585                 590         


Lys Lys Ser Lys Val Asn Thr Ala Leu Arg Asn Leu Arg Tyr Arg Arg 
        595                 600                 605             


Gly Ile His Lys Cys Ile Glu Cys Cys Ser Glu Ile Lys Asp Phe Ala 
    610                 615                 620                 


Asn His Phe Pro Thr Tyr Val His Cys Ser Phe Cys Arg Tyr Asn Thr 
625                 630                 635                 640 


Ser Cys Ser Lys Ala Tyr Val Asn His Met Met Ser Phe His Ser Asn 
                645                 650                 655     


Arg Pro Ser Lys Arg Phe Cys Ile Phe Lys Lys His Ser Glu Asn Leu 
            660                 665                 670         


Arg Gly Ile Thr Leu Val Cys Leu Asn Cys Asp Phe Leu Ser Asp Val 
        675                 680                 685             


Ser Gly Leu Asp Asn Met Ala Thr His Leu Ser Gln His Lys Thr His 
    690                 695                 700                 


Thr Cys Gln Val Val Met Gln Lys Val Ser Val Cys Ile Pro Thr Ser 
705                 710                 715                 720 


Glu His Leu Ser Glu Leu Lys Lys Glu Ala Pro Ala Lys Glu Gln Glu 
                725                 730                 735     


Pro Val Ser Lys Glu Ile Ala Arg Pro Asn Met Ala Glu Arg Glu Thr 
            740                 745                 750         


Glu Thr Ser Asn Ser Glu Ser Lys Gln Asp Lys Ala Ala Ser Ser Lys 
        755                 760                 765             


Glu Lys Asn Gly Cys Asn Ala Asn Ser Phe Glu Gly Ser Ser Thr Thr 
    770                 775                 780                 


Lys Ser Glu Glu Ser Ile Thr Val Ser Asp Lys Glu Asn Glu Thr Cys 
785                 790                 795                 800 


Leu Ala Asp Gln Glu Thr Gly Ser Lys Asn Ile Val Ser Cys Asp Ser 
                805                 810                 815     


Asn Ile Gly Ala Asp Lys Val Glu Lys Lys Lys Gln Ile Gln His Val 
            820                 825                 830         


Cys Gln Glu Met Glu Leu Lys Met Cys Gln Ser Ser Glu Asn Ile Ile 
        835                 840                 845             


Leu Ser Asp Gln Ile Lys Asp His Asn Ser Ser Glu Ala Arg Phe Ser 
    850                 855                 860                 


Ser Lys Asn Ile Lys Asp Leu Arg Leu Ala Ser Asp Asn Val Ser Ile 
865                 870                 875                 880 


Asp Gln Phe Leu Arg Lys Arg His Glu Pro Glu Ser Val Ser Ser Asp 
                885                 890                 895     


Val Ser Glu Gln Gly Ser Ile His Leu Glu Pro Leu Thr Pro Ser Glu 
            900                 905                 910         


Val Leu Glu Tyr Glu Ala Thr Glu Ile Leu Gln Lys Gly Ser Gly Asp 
        915                 920                 925             


Pro Ser Ala Lys Thr Asp Glu Val Val Ser Asp Gln Thr Asp Asp Ile 
    930                 935                 940                 


Pro Gly Gly Asn Asn Pro Ser Thr Thr Glu Ala Thr Val Asp Leu Glu 
945                 950                 955                 960 


Asp Glu Lys Glu Arg Ser 
                965     


<210>  3248
<211>  2164
<212>  DNA
<213>  Homosapiens

<400>  3248
acggctcggc tgccagctcc gcaatgggag ccgccgccgt cgccgcagtg tagtttttcg     60

tgctcctcct tttcctcctc ctctttctcc tcctcctcag ggctccagtc aggccgatcc    120

gctccgctca cggaaggaaa acagaaataa cttgctggct tgtctggagt cacatggtga    180

caatttacag aaagtcatct ctgcagcttg atgggcgaca acccttttca accaaaaagt    240

aattcaaaaa tggcagaact gtttatggaa tgtgaagaag aggagctgga accatggcag    300

aagaaagtaa aagaagttga ggatgacgat gatgatgagc caatctttgt tggcgagata    360

tcaagttcaa aaccagcaat ttcaaatatt ttgaacagag ttaaccccag ctcatattca    420

aggggactaa agaatggtgc actcagtcga ggtattactg ctgcattcaa gcctacaagt    480

caacactaca cgaatccaac atcaaatcca gtgcctgcct caccaataaa ttttcatcct    540

gagtctagat cttcagatag ttctgttatt gttcagcctt tttctaaacc tgtaagtgtt    600

tctaaaacta tacggccagc tcagggatcc attggatgtt gtttatcaat atcaacagta    660

cccagttaca attctggact gtcataagta gtcatccagt agaagcatag ttagcatcag    720

aaaatgtcac catattttcg ctagctcaag cagtacccca agtaataact gaaggagcta    780

actacccaac ctgttaataa caggcagtat gcctaaatag gtacagtaat gaaaactata    840

ctatcaaaat gtgaataaaa ttatagtcag ccataaatat tgcataatga caaatattta    900

agattgcaga cgggaccagg tattcttaat tgggaaaaca gtcaagtgac catcatagct    960

ttttattctg aaaacattcc ttcatagttc agttagttaa aaaaaaacaa acattttttc   1020

ctattacaaa aaactcccac tttttttgtt acaaaaagta atagaaaatg gtaatagtta   1080

acattcattg agctgttaat atgtataagt gtttgtgcta aatgctatag gtaaattcat   1140

ttcatttagt tcttaaacat ccccatgaag taaacactat tattatcctc attttttagt   1200

tgaggaaact gaggctcata gaggttgaaa gatttattca agatcccaaa gctggcagtt   1260

gatggatctg ggatttcaat ccagcctaac ccatagttta tatgtatatg cacacataca   1320

tacatatatg ttgtgtataa atgtacactt ttttagacat gaaagaattg ccttagttga   1380

acagttctca gattgtagtt tgcaatcccc tggggttccc caagaccctt tcagaggttt   1440

gagggtcaac agtgttgtca ttataatcaa agactgtttt ccttttccac tgtgttggca   1500

tttgcactgg tgatgctaaa gtaatggtgg ataagctgct ggtgccttag tgtgaatcaa   1560

ggtagtgcca ccaaagtgta cttgtagttt ctgtattagt cacctgccgt gcactcacag   1620

taaactacat tactcaactg agtattaccc agttataccc aatccctgat gaagtattaa   1680

aatgttatta gttttattaa ctctctacac ttgaatgtgt gttttttaaa atattctgtg   1740

tgatgacatg ggtagtgtgc ataaagtacc tctgtgtctg aagtatgata gttgtcttga   1800

ggaaaagcac ttgtgtgatt gaattgtgag gtaaactacc tgattttttt ttgttgttac   1860

atgaaagaat gactgacaaa tctttaaagt atttacaata tcactccaga aaagaaaaca   1920

aatcaaataa atattgactc aaaactctcc aagtacatat caaaatctca ggaagggaaa   1980

aaagagtcta aagaacaaaa tataacacta ttttatttca gtcatgttag ttcagtttcc   2040

acagtttgaa ctgggtatag attaatatct aaaaccaaaa aatgaacatg tgtatagtga   2100

tgctgaaaaa tgtgcattat tttttattta tattttagga ataataaagt tagttattaa   2160

agaa                                                                2164


<210>  3249
<211>  158
<212>  PRT
<213>  Homosapiens

<400>  3249

Met Gly Asp Asn Pro Phe Gln Pro Lys Ser Asn Ser Lys Met Ala Glu 
1               5                   10                  15      


Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu Pro Trp Gln Lys Lys 
            20                  25                  30          


Val Lys Glu Val Glu Asp Asp Asp Asp Asp Glu Pro Ile Phe Val Gly 
        35                  40                  45              


Glu Ile Ser Ser Ser Lys Pro Ala Ile Ser Asn Ile Leu Asn Arg Val 
    50                  55                  60                  


Asn Pro Ser Ser Tyr Ser Arg Gly Leu Lys Asn Gly Ala Leu Ser Arg 
65                  70                  75                  80  


Gly Ile Thr Ala Ala Phe Lys Pro Thr Ser Gln His Tyr Thr Asn Pro 
                85                  90                  95      


Thr Ser Asn Pro Val Pro Ala Ser Pro Ile Asn Phe His Pro Glu Ser 
            100                 105                 110         


Arg Ser Ser Asp Ser Ser Val Ile Val Gln Pro Phe Ser Lys Pro Val 
        115                 120                 125             


Ser Val Ser Lys Thr Ile Arg Pro Ala Gln Gly Ser Ile Gly Cys Cys 
    130                 135                 140                 


Leu Ser Ile Ser Thr Val Pro Ser Tyr Asn Ser Gly Leu Ser 
145                 150                 155             


<210>  3250
<211>  4484
<212>  DNA
<213>  Homosapiens

<400>  3250
acggctcggc tgccagctcc gcaatgggag ccgccgccgt cgccgcagtg tagtttttcg     60

tgctcctcct tttcctcctc ctctttctcc tcctcctcag ggctccagtc aggccgatcc    120

gctccgctca cggaaggaaa acagaaataa cttgctggct tgtctggagt cacatgtact    180

taggtgacaa tttacagaaa gtcatctctg cagcttgatg ggcgacaacc cttttcaacc    240

aaaaagtaat tcaaaaatgg cagaactgtt tatggaatgt gaagaagagg agctggaacc    300

atggcagaag aaagtaaaag aagttgagga tgacgatgat gatgagccaa tctttgttgg    360

cgagatatca agttcaaaac cagcaatttc aaatattttg aacagagtta accccagctc    420

atattcaagg ggactaaaga atggtgcact cagtcgaggt attactgctg cattcaagcc    480

tacaagtcaa cactacacga atccaacatc aaatccagtg cctgcctcac caataaattt    540

tcatcctgag tctagatctt cagatagttc tgttattgtt cagccttttt ctaaacctgg    600

ttatataaca aactcatcac gagttgtgtc taataagtca tcagagttac tgtttgactt    660

gacccaggat acaggattat cacattacca agggggacca acactttcta tggcaggtat    720

gagtgaaagt tcatttttat caaaacgtcc ttctacttct gaagtaaata atgttaatcc    780

aaagaagcct aaacccagcg aaagtgtttc tggagcaaat tcctcagctg tattaccttc    840

agttaaatct ccttcagtga cttcttccca ggctatgcta gcaaaaggta caaatacctc    900

atcaaatcag tctaaaaatg gaacaccttt tccaagagct tgtccaaagt gcaacattca    960

tttcaatctt ttggatcctt tgaaaaatca catgaagtat tgttgtccag acatgataaa   1020

taactttttg ggactggcta aaacagaatt ttcaagtaca gtaaataaaa acacaactat   1080

tgattcagag aaaggaaaat tgatcatgtt agttaatgac ttttattatg gaaaacatga   1140

aggagatgtc caggaggaac agaagactca cacaaccttt aaatgcttca gttgcttgaa   1200

aattctaaaa aataacatta ggtttatgaa ccacatgaaa caccatttgg aacttgagaa   1260

gcagagcagt gagagctggg aaaaccatac cacctgccag cactgctacc gtcagtttcc   1320

cacaccattt cagttgcagt gtcacatcga aagtacacat acgccccatg aattttctac   1380

tatttgtaaa atctgtgaat tgtcatttga aacagaacat gttcttttac aacatatgaa   1440

ggacaatcat aaacctggtg aaatgccata tgtctgccag gtttgtaatt atagatcatc   1500

atcattttct gatgtagaaa ctcattttag aacatcccat gaaaacacta agaacttgct   1560

atgcccgttt tgcctcaaag ttattaaaat tgcaacacca tatatgcatc attatatgaa   1620

gcatcagaaa aaaggaatac atcgttgtac aaaatgcagg ctgcagtttt tgacatgcaa   1680

ggagaaaatg gatcataaga ctcaacacca tcgaacattt ataaaaccta aacaactaga   1740

aggattgcct cctggaacaa aagttactat tcgagcttca gttggacctc tgcaatcagg   1800

agcttcacct acaccttcca ttagtgcaag tgcttctacc cttcagctct cacctccaag   1860

gactaaaaat ataactgcta aaaatcctgc aaaatctaat acaagtaaac ctaatacagt   1920

caaatccaac gcaagtaaac ctaatacaag taagcctaat ggaagtaaat ctaaatacaa   1980

accaaaaatc tctaatatgc aaaagaaaca aagcacattg gctagtagca ataaaaaaag   2040

taaagtcaat acagcattga ggaatttaag gtatcgtcgg ggcattcaca aatgcattga   2100

gtgttgttcc gaaataaaag attttgcaaa ccactttcct acgtacgtcc actgtagttt   2160

ttgcagatac aacactagct gtagcaaagc ctatgtaaat catatgatga gctttcatag   2220

taaccgtcca agcaaaaggt tttgtatttt taagaagcat tcagaaaatc tccggggcat   2280

tactctagtg tgccttaatt gtgatttcct aagtgatgtt tctggcttag ataatatggc   2340

tacacactta agtcaacata aaactcatac ttgccaagtt gtaatgcaga aagtttctgt   2400

ttgtatccca acttctgagc acctttctga attaaaaaaa gaagctcccg caaaggaaca   2460

agaacctgtg tctaaggaaa ttgcaagacc taacatggct gaaagagaaa cagaaacatc   2520

aaattctgaa agtaaacaag ataaagctgc ttcttcaaaa gaaaaaaatg gatgtaatgc   2580

aaattcattt gaaggctcat caacaacaaa aagtgaagaa agcataacag tttcagataa   2640

ggaaaatgaa acctgtcttg cagaccagga aactggctca aaaaacatcg tcagttgtga   2700

ttcaaatatt ggtgcagata aagtggaaaa gaaaaaacaa atacaacacg tttgtcagga   2760

aatggagttg aagatgtgcc aaagttcaga aaacataatc ttatctgatc agattaaaga   2820

tcacaactcc agtgaagcca gattttcttc aaagaatatt aaggatttgc gattagcatc   2880

agataatgta agcattgatc agtttttgag aaaaagacat gaacctgaat ctgttagttc   2940

tgatgttagc gagcaaggca gtattcattt ggaacctctg actccatccg aggtacttga   3000

gtatgaagcc acagagattc ttcagaaagg tagtggtgat ccttcagcca agactgatga   3060

agtagtgtct gatcaaacag atgacattcc tggaggaaat aaccctagca caacagaggc   3120

aacagtagac ctggaagatg aaaaagaaag aagttgaaat tagtcatttt aagtttcagt   3180

gtaccaacga taagggcatt tggaacagtg ctatcaggtg agctcagtgg tgctgttgta   3240

ggttcagaaa tggaaatatg taagggaggt cacacataca ctttacctgt atgttcaacc   3300

tatgttatca aacaaatcaa ttcaccaata atagcatgat tagtagggat tcccaaaaag   3360

tttttaaaaa cacgaacagg attttaatga taattaaatt tgcagtggaa aggtctcatt   3420

taatggtttt caaggaaatg ggatttggtt gctgacatga attgatgata ttagtaatat   3480

ttataaagcc tttcaaactt ccatcaatcc taagctaaaa atctttatta cctgtatatc   3540

cttttcagtt aactgagagg aagggatttg gaaaccatgt acttttgggg agtaattgat   3600

taaaaacaat ggctgattgg cattgttaat gaaggcttta tttgtgagga tgatgctggt   3660

aaatggagca tgcttagagt actaaattga tctaatgaga atttggatga acataaactt   3720

aattttggat ttaatataac attccagtca gacgcatgta aacagaatat ttgaatcttt   3780

gtacctccat acaagtgtta gcctgccagg ctgtaagctt accttaatta aactttcagt   3840

gaaagtggaa ttattaagat ataaatttat atttgtgctt tttgtcagtg tgtaagctgt   3900

gtagaaattc tttgatgtat tagttgtatt aatgtaaagt agaaacccat tgttgaaact   3960

cctgtagcta ttatgctttt aatattgttt taatgatctt ccttagaaat aggcccataa   4020

aaatggtctg gaagccaaac caaagtatgg tataatgtag atattgtaaa gcagtaaact   4080

gaaaacatgt cctggcatgt attcagccat gtttaagtga cttttctgta attgtaaaat   4140

aaaaacttca aatgggacct aaaacagtga tgtaaaagaa ctggttttgg aaatttagcc   4200

taatttatct ataagatggc tgctaaattg atttttcagt tctttttatc atctagaata   4260

taatagatat agaaatgaat aatatgaaga acagtagttt gctttgaaat actaataaac   4320

ttttatttaa aatgcttcat ttttacttct taaaatgtgc tttggattct taaattttgt   4380

ttcactgaat gttcaatgtt ttaaatggcg attaaaatac tctgctgtat atagtagttt   4440

ttgagtaaat atttgcaata aaaatctgcc cccgaataaa aaaa                    4484


<210>  3251
<211>  979
<212>  PRT
<213>  Homosapiens

<400>  3251

Met Gly Asp Asn Pro Phe Gln Pro Lys Ser Asn Ser Lys Met Ala Glu 
1               5                   10                  15      


Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu Pro Trp Gln Lys Lys 
            20                  25                  30          


Val Lys Glu Val Glu Asp Asp Asp Asp Asp Glu Pro Ile Phe Val Gly 
        35                  40                  45              


Glu Ile Ser Ser Ser Lys Pro Ala Ile Ser Asn Ile Leu Asn Arg Val 
    50                  55                  60                  


Asn Pro Ser Ser Tyr Ser Arg Gly Leu Lys Asn Gly Ala Leu Ser Arg 
65                  70                  75                  80  


Gly Ile Thr Ala Ala Phe Lys Pro Thr Ser Gln His Tyr Thr Asn Pro 
                85                  90                  95      


Thr Ser Asn Pro Val Pro Ala Ser Pro Ile Asn Phe His Pro Glu Ser 
            100                 105                 110         


Arg Ser Ser Asp Ser Ser Val Ile Val Gln Pro Phe Ser Lys Pro Gly 
        115                 120                 125             


Tyr Ile Thr Asn Ser Ser Arg Val Val Ser Asn Lys Ser Ser Glu Leu 
    130                 135                 140                 


Leu Phe Asp Leu Thr Gln Asp Thr Gly Leu Ser His Tyr Gln Gly Gly 
145                 150                 155                 160 


Pro Thr Leu Ser Met Ala Gly Met Ser Glu Ser Ser Phe Leu Ser Lys 
                165                 170                 175     


Arg Pro Ser Thr Ser Glu Val Asn Asn Val Asn Pro Lys Lys Pro Lys 
            180                 185                 190         


Pro Ser Glu Ser Val Ser Gly Ala Asn Ser Ser Ala Val Leu Pro Ser 
        195                 200                 205             


Val Lys Ser Pro Ser Val Thr Ser Ser Gln Ala Met Leu Ala Lys Gly 
    210                 215                 220                 


Thr Asn Thr Ser Ser Asn Gln Ser Lys Asn Gly Thr Pro Phe Pro Arg 
225                 230                 235                 240 


Ala Cys Pro Lys Cys Asn Ile His Phe Asn Leu Leu Asp Pro Leu Lys 
                245                 250                 255     


Asn His Met Lys Tyr Cys Cys Pro Asp Met Ile Asn Asn Phe Leu Gly 
            260                 265                 270         


Leu Ala Lys Thr Glu Phe Ser Ser Thr Val Asn Lys Asn Thr Thr Ile 
        275                 280                 285             


Asp Ser Glu Lys Gly Lys Leu Ile Met Leu Val Asn Asp Phe Tyr Tyr 
    290                 295                 300                 


Gly Lys His Glu Gly Asp Val Gln Glu Glu Gln Lys Thr His Thr Thr 
305                 310                 315                 320 


Phe Lys Cys Phe Ser Cys Leu Lys Ile Leu Lys Asn Asn Ile Arg Phe 
                325                 330                 335     


Met Asn His Met Lys His His Leu Glu Leu Glu Lys Gln Ser Ser Glu 
            340                 345                 350         


Ser Trp Glu Asn His Thr Thr Cys Gln His Cys Tyr Arg Gln Phe Pro 
        355                 360                 365             


Thr Pro Phe Gln Leu Gln Cys His Ile Glu Ser Thr His Thr Pro His 
    370                 375                 380                 


Glu Phe Ser Thr Ile Cys Lys Ile Cys Glu Leu Ser Phe Glu Thr Glu 
385                 390                 395                 400 


His Val Leu Leu Gln His Met Lys Asp Asn His Lys Pro Gly Glu Met 
                405                 410                 415     


Pro Tyr Val Cys Gln Val Cys Asn Tyr Arg Ser Ser Ser Phe Ser Asp 
            420                 425                 430         


Val Glu Thr His Phe Arg Thr Ser His Glu Asn Thr Lys Asn Leu Leu 
        435                 440                 445             


Cys Pro Phe Cys Leu Lys Val Ile Lys Ile Ala Thr Pro Tyr Met His 
    450                 455                 460                 


His Tyr Met Lys His Gln Lys Lys Gly Ile His Arg Cys Thr Lys Cys 
465                 470                 475                 480 


Arg Leu Gln Phe Leu Thr Cys Lys Glu Lys Met Asp His Lys Thr Gln 
                485                 490                 495     


His His Arg Thr Phe Ile Lys Pro Lys Gln Leu Glu Gly Leu Pro Pro 
            500                 505                 510         


Gly Thr Lys Val Thr Ile Arg Ala Ser Val Gly Pro Leu Gln Ser Gly 
        515                 520                 525             


Ala Ser Pro Thr Pro Ser Ile Ser Ala Ser Ala Ser Thr Leu Gln Leu 
    530                 535                 540                 


Ser Pro Pro Arg Thr Lys Asn Ile Thr Ala Lys Asn Pro Ala Lys Ser 
545                 550                 555                 560 


Asn Thr Ser Lys Pro Asn Thr Val Lys Ser Asn Ala Ser Lys Pro Asn 
                565                 570                 575     


Thr Ser Lys Pro Asn Gly Ser Lys Ser Lys Tyr Lys Pro Lys Ile Ser 
            580                 585                 590         


Asn Met Gln Lys Lys Gln Ser Thr Leu Ala Ser Ser Asn Lys Lys Ser 
        595                 600                 605             


Lys Val Asn Thr Ala Leu Arg Asn Leu Arg Tyr Arg Arg Gly Ile His 
    610                 615                 620                 


Lys Cys Ile Glu Cys Cys Ser Glu Ile Lys Asp Phe Ala Asn His Phe 
625                 630                 635                 640 


Pro Thr Tyr Val His Cys Ser Phe Cys Arg Tyr Asn Thr Ser Cys Ser 
                645                 650                 655     


Lys Ala Tyr Val Asn His Met Met Ser Phe His Ser Asn Arg Pro Ser 
            660                 665                 670         


Lys Arg Phe Cys Ile Phe Lys Lys His Ser Glu Asn Leu Arg Gly Ile 
        675                 680                 685             


Thr Leu Val Cys Leu Asn Cys Asp Phe Leu Ser Asp Val Ser Gly Leu 
    690                 695                 700                 


Asp Asn Met Ala Thr His Leu Ser Gln His Lys Thr His Thr Cys Gln 
705                 710                 715                 720 


Val Val Met Gln Lys Val Ser Val Cys Ile Pro Thr Ser Glu His Leu 
                725                 730                 735     


Ser Glu Leu Lys Lys Glu Ala Pro Ala Lys Glu Gln Glu Pro Val Ser 
            740                 745                 750         


Lys Glu Ile Ala Arg Pro Asn Met Ala Glu Arg Glu Thr Glu Thr Ser 
        755                 760                 765             


Asn Ser Glu Ser Lys Gln Asp Lys Ala Ala Ser Ser Lys Glu Lys Asn 
    770                 775                 780                 


Gly Cys Asn Ala Asn Ser Phe Glu Gly Ser Ser Thr Thr Lys Ser Glu 
785                 790                 795                 800 


Glu Ser Ile Thr Val Ser Asp Lys Glu Asn Glu Thr Cys Leu Ala Asp 
                805                 810                 815     


Gln Glu Thr Gly Ser Lys Asn Ile Val Ser Cys Asp Ser Asn Ile Gly 
            820                 825                 830         


Ala Asp Lys Val Glu Lys Lys Lys Gln Ile Gln His Val Cys Gln Glu 
        835                 840                 845             


Met Glu Leu Lys Met Cys Gln Ser Ser Glu Asn Ile Ile Leu Ser Asp 
    850                 855                 860                 


Gln Ile Lys Asp His Asn Ser Ser Glu Ala Arg Phe Ser Ser Lys Asn 
865                 870                 875                 880 


Ile Lys Asp Leu Arg Leu Ala Ser Asp Asn Val Ser Ile Asp Gln Phe 
                885                 890                 895     


Leu Arg Lys Arg His Glu Pro Glu Ser Val Ser Ser Asp Val Ser Glu 
            900                 905                 910         


Gln Gly Ser Ile His Leu Glu Pro Leu Thr Pro Ser Glu Val Leu Glu 
        915                 920                 925             


Tyr Glu Ala Thr Glu Ile Leu Gln Lys Gly Ser Gly Asp Pro Ser Ala 
    930                 935                 940                 


Lys Thr Asp Glu Val Val Ser Asp Gln Thr Asp Asp Ile Pro Gly Gly 
945                 950                 955                 960 


Asn Asn Pro Ser Thr Thr Glu Ala Thr Val Asp Leu Glu Asp Glu Lys 
                965                 970                 975     


Glu Arg Ser 
            


<210>  3252
<211>  1294
<212>  DNA
<213>  Homosapiens

<400>  3252
ggaagggggg caggagaaaa aagcttttcc aaaaaagtat tggctgtctt gaggaatgcg     60

gtcgccccct tgggaaagta catatctggg agaagcaggc ggctccgcgc tcgcactccc    120

gctcctccgc ccgaccgcgc gctcgccccg ccgctcctgc tgcagcccca gggcccctcg    180

ccgccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc gacaaggaga    240

acgccttgga tcgagctgag caggcggagg ccgacaagaa ggcggcggaa gacaggagca    300

agcagctgga agatgagctg gtgtcactgc aaaagaaact caagggcacc gaagatgaac    360

tggacaaata ctctgaggct ctcaaagatg cccaggagaa gctggagctg gcagagaaaa    420

aggccaccga tgctgaagcc gacgtagctt ctctgaacag acgcatccag ctggttgagg    480

aagagttgga tcgtgcccag gagcgtctgg caacagcttt gcagaagctg gaggaagctg    540

agaaggcagc agatgagagt gagagaggca tgaaagtcat tgagagtcga gcccaaaaag    600

atgaagaaaa aatggaaatt caggagatcc aactgaaaga ggccaagcac attgctgaag    660

atgccgaccg caaatatgaa gaggtggccc gtaagctggt catcattgag agcgacctgg    720

aacgtgcaga ggagcgggct gagctctcag aaggccaagt ccgacagctg gaagaacaat    780

taagaataat ggatcagacc ttgaaagcat taatggctgc agaggataag tactcgcaga    840

aggaagacag atatgaggaa gagatcaagg tcctttccga caagctgaag gaggctgaga    900

ctcgggctga gtttgcggag aggtcagtaa ctaaattgga gaaaagcatt gatgacttag    960

aagacgagct gtacgctcag aaactgaagt acaaagccat cagcgaggag ctggaccacg   1020

ctctcaacga tatgacttcc atgtaaacgt tcatccactc tgcctgctta caccctgccc   1080

tcatgctaat ataagtttct ttgcttcact tctcccaaga ctccctcgtc gagctggatg   1140

tcccacctct ctgagctctg catttgtcta ttctccagct gaccctggtt ctctctctta   1200

gcatcctgcc ttagagccag gcacacactg tgctttctat tgtacagaag ctcttcgttt   1260

cagtgtcaaa taaacactgt gtaagctaaa aaaa                               1294


<210>  3253
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  3253

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Gln Val Arg Gln 
            180                 185                 190         


Leu Glu Glu Gln Leu Arg Ile Met Asp Gln Thr Leu Lys Ala Leu Met 
        195                 200                 205             


Ala Ala Glu Asp Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
            260                 265                 270         


Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Met 
        275                 280                 


<210>  3254
<211>  1797
<212>  DNA
<213>  Homosapiens

<400>  3254
ggaagggggg caggagaaaa aagcttttcc aaaaaagtat tggctgtctt gaggaatgcg     60

gtcgccccct tgggaaagta catatctggg agaagcaggc ggctccgcgc tcgcactccc    120

gctcctccgc ccgaccgcgc gctcgccccg ccgctcctgc tgcagcccca gggcccctcg    180

ccgccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc gacaaggaga    240

acgccttgga tcgagctgag caggcggagg ccgacaagaa ggcggcggaa gacaggagca    300

agcagctgga agatgagctg gtgtcactgc aaaagaaact caagggcacc gaagatgaac    360

tggacaaata ctctgaggct ctcaaagatg cccaggagaa gctggagctg gcagagaaaa    420

aggccaccga tgctgaagcc gacgtagctt ctctgaacag acgcatccag ctggttgagg    480

aagagttgga tcgtgcccag gagcgtctgg caacagcttt gcagaagctg gaggaagctg    540

agaaggcagc agatgagagt gagagaggca tgaaagtcat tgagagtcga gcccaaaaag    600

atgaagaaaa aatggaaatt caggagatcc aactgaaaga ggccaagcac attgctgaag    660

atgccgaccg caaatatgaa gaggtggccc gtaagctggt catcattgag agcgacctgg    720

aacgtgcaga ggagcgggct gagctctcag aaggcaaatg tgccgagctt gaagaagaat    780

tgaaaactgt gacgaacaac ttgaagtcac tggaggctca ggctgagaag tactcgcaga    840

aggaagacag atatgaggaa gagatcaagg tcctttccga caagctgaag gaggctgaga    900

ctcgggctga gtttgcggag aggtcagtaa ctaaattgga gaaaagcatt gatgacttag    960

aagagaaagt ggctcatgcc aaagaagaaa accttagtat gcatcagatg ctggatcaga   1020

ctttactgga gttaaacaac atgtgaaaac ctccttagct gcgaccacat tctttcgttt   1080

tgttttgttt tgtttttaaa cacctgctta ccccttaaat gcaatttatt tacttttacc   1140

actgtcacag aaacatccac aagataccag ctaggtcagg gggtggggaa aacacataca   1200

aaaaggcaag cccatgtcag ggcgatcctg gttcaaatgt gccatttccc gggttgatgc   1260

tgccacactt tgtagagagt ttagcaacac agtgtgctta gtcagcgtag gaatcctcac   1320

taaagcagaa gaagttccat tcaaagtgcc aatgatagag tcaacaggaa ggttaatgtt   1380

ggaaacacaa tcaggtgtgg attggtgcta ctttgaacaa aaggtccccc tgtggtcttt   1440

tgttcaacat tgtacaatgt agaactctgt ccaacactaa tttattttgt cttgagtttt   1500

actacaagat gagactatgg atcccgcatg cctgaattca ctaaagccaa gggtctgtaa   1560

gccacgctgc tcttccgaga cttccattcc tttctgattg gcacacgtgc agctcatgac   1620

aatctgtagg ataacaatca gtgtggattt ccactctttt cagtccttca tgttaaagat   1680

ttagacacca catacaactg gtaaaggacg ttttcttgag agttttaact atatgtaaac   1740

attgtataat gatatggaat aaaatgcaca ttgtaggaca ttttctaaaa aaaaaaa      1797


<210>  3255
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  3255

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Glu Lys Val Ala His Ala Lys Glu Glu Asn Leu Ser Met His Gln 
            260                 265                 270         


Met Leu Asp Gln Thr Leu Leu Glu Leu Asn Asn Met 
        275                 280                 


<210>  3256
<211>  1246
<212>  DNA
<213>  Homosapiens

<400>  3256
ggaagggggg caggagaaaa aagcttttcc aaaaaagtat tggctgtctt gaggaatgcg     60

gtcgccccct tgggaaagta catatctggg agaagcaggc ggctccgcgc tcgcactccc    120

gctcctccgc ccgaccgcgc gctcgccccg ccgctcctgc tgcagcccca gggcccctcg    180

ccgccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc gacaaggaga    240

acgccttgga tcgagctgag caggcggagg ccgacaagaa ggcggcggaa gacaggagca    300

agcagctgga agatgagctg gtgtcactgc aaaagaaact caagggcacc gaagatgaac    360

tggacaaata ctctgaggct ctcaaagatg cccaggagaa gctggagctg gcagagaaaa    420

aggccaccga tgctgaagcc gacgtagctt ctctgaacag acgcatccag ctggttgagg    480

aagagttgga tcgtgcccag gagcgtctgg caacagcttt gcagaagctg gaggaagctg    540

agaaggcagc agatgagagt gagagaggca tgaaagtcat tgagagtcga gcccaaaaag    600

atgaagaaaa aatggaaatt caggagatcc aactgaaaga ggccaagcac attgctgaag    660

atgccgaccg caaatatgaa gaggtggccc gtaagctggt catcattgag agcgacctgg    720

aacgtgcaga ggagcgggct gagctctcag aaggcaaatg tgccgagctt gaagaagaat    780

tgaaaactgt gacgaacaac ttgaagtcac tggaggctca ggctgagaag tactcgcaga    840

aggaagacag atatgaggaa gagatcaagg tcctttccga caagctgaag gaggctgaga    900

ctcgggctga gtttgcggag aggtcagtaa ctaaattgga gaaaagcatt gatgacttag    960

aagacgagct gtacgctcag aaactgaagt acaaagccat cagcgaggag ctggaccacg   1020

ctctcaacga tatgacttcc atataagttt ctttgcttca cttctcccaa gactccctcg   1080

tcgagctgga tgtcccacct ctctgagctc tgcatttgtc tattctccag ctgaccctgg   1140

ttctctctct tagcatcctg ccttagagcc aggcacacac tgtgctttct attgtacaga   1200

agctcttcgt ttcagtgtca aataaacact gtgtaagcta aaaaaa                  1246


<210>  3257
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  3257

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
            260                 265                 270         


Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
        275                 280                 


<210>  3258
<211>  1797
<212>  DNA
<213>  Homosapiens

<400>  3258
ggaagggggg caggagaaaa aagcttttcc aaaaaagtat tggctgtctt gaggaatgcg     60

gtcgccccct tgggaaagta catatctggg agaagcaggc ggctccgcgc tcgcactccc    120

gctcctccgc ccgaccgcgc gctcgccccg ccgctcctgc tgcagcccca gggcccctcg    180

ccgccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc gacaaggaga    240

acgccttgga tcgagctgag caggcggagg ccgacaagaa ggcggcggaa gacaggagca    300

agcagctgga agatgagctg gtgtcactgc aaaagaaact caagggcacc gaagatgaac    360

tggacaaata ctctgaggct ctcaaagatg cccaggagaa gctggagctg gcagagaaaa    420

aggccaccga tgctgaagcc gacgtagctt ctctgaacag acgcatccag ctggttgagg    480

aagagttgga tcgtgcccag gagcgtctgg caacagcttt gcagaagctg gaggaagctg    540

agaaggcagc agatgagagt gagagaggca tgaaagtcat tgagagtcga gcccaaaaag    600

atgaagaaaa aatggaaatt caggagatcc aactgaaaga ggccaagcac attgctgaag    660

atgccgaccg caaatatgaa gaggtggccc gtaagctggt catcattgag agcgacctgg    720

aacgtgcaga ggagcgggct gagctctcag aaggccaagt ccgacagctg gaagaacaat    780

taagaataat ggatcagacc ttgaaagcat taatggctgc agaggataag tactcgcaga    840

aggaagacag atatgaggaa gagatcaagg tcctttccga caagctgaag gaggctgaga    900

ctcgggctga gtttgcggag aggtcagtaa ctaaattgga gaaaagcatt gatgacttag    960

aagagaaagt ggctcatgcc aaagaagaaa accttagtat gcatcagatg ctggatcaga   1020

ctttactgga gttaaacaac atgtgaaaac ctccttagct gcgaccacat tctttcgttt   1080

tgttttgttt tgtttttaaa cacctgctta ccccttaaat gcaatttatt tacttttacc   1140

actgtcacag aaacatccac aagataccag ctaggtcagg gggtggggaa aacacataca   1200

aaaaggcaag cccatgtcag ggcgatcctg gttcaaatgt gccatttccc gggttgatgc   1260

tgccacactt tgtagagagt ttagcaacac agtgtgctta gtcagcgtag gaatcctcac   1320

taaagcagaa gaagttccat tcaaagtgcc aatgatagag tcaacaggaa ggttaatgtt   1380

ggaaacacaa tcaggtgtgg attggtgcta ctttgaacaa aaggtccccc tgtggtcttt   1440

tgttcaacat tgtacaatgt agaactctgt ccaacactaa tttattttgt cttgagtttt   1500

actacaagat gagactatgg atcccgcatg cctgaattca ctaaagccaa gggtctgtaa   1560

gccacgctgc tcttccgaga cttccattcc tttctgattg gcacacgtgc agctcatgac   1620

aatctgtagg ataacaatca gtgtggattt ccactctttt cagtccttca tgttaaagat   1680

ttagacacca catacaactg gtaaaggacg ttttcttgag agttttaact atatgtaaac   1740

attgtataat gatatggaat aaaatgcaca ttgtaggaca ttttctaaaa aaaaaaa      1797


<210>  3259
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  3259

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Gln Val Arg Gln 
            180                 185                 190         


Leu Glu Glu Gln Leu Arg Ile Met Asp Gln Thr Leu Lys Ala Leu Met 
        195                 200                 205             


Ala Ala Glu Asp Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Glu Lys Val Ala His Ala Lys Glu Glu Asn Leu Ser Met His Gln 
            260                 265                 270         


Met Leu Asp Gln Thr Leu Leu Glu Leu Asn Asn Met 
        275                 280                 


<210>  3260
<211>  1797
<212>  DNA
<213>  Homosapiens

<400>  3260
ggaagggggg caggagaaaa aagcttttcc aaaaaagtat tggctgtctt gaggaatgcg     60

gtcgccccct tgggaaagta catatctggg agaagcaggc ggctccgcgc tcgcactccc    120

gctcctccgc ccgaccgcgc gctcgccccg ccgctcctgc tgcagcccca gggcccctcg    180

ccgccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc gacaaggaga    240

acgccttgga tcgagctgag caggcggagg ccgacaagaa ggcggcggaa gacaggagca    300

agcagctcga ggaggacatc gcggccaagg agaagttgct gcgggtgtcg gaggacgagc    360

gggaccgggt gctggaggag ctgcacaagg cggaggacag cctcctggcc gccgaagagg    420

ccgccgccaa ggctgaagcc gacgtagctt ctctgaacag acgcatccag ctggttgagg    480

aagagttgga tcgtgcccag gagcgtctgg caacagcttt gcagaagctg gaggaagctg    540

agaaggcagc agatgagagt gagagaggca tgaaagtcat tgagagtcga gcccaaaaag    600

atgaagaaaa aatggaaatt caggagatcc aactgaaaga ggccaagcac attgctgaag    660

atgccgaccg caaatatgaa gaggtggccc gtaagctggt catcattgag agcgacctgg    720

aacgtgcaga ggagcgggct gagctctcag aaggcaaatg tgccgagctt gaagaagaat    780

tgaaaactgt gacgaacaac ttgaagtcac tggaggctca ggctgagaag tactcgcaga    840

aggaagacag atatgaggaa gagatcaagg tcctttccga caagctgaag gaggctgaga    900

ctcgggctga gtttgcggag aggtcagtaa ctaaattgga gaaaagcatt gatgacttag    960

aagagaaagt ggctcatgcc aaagaagaaa accttagtat gcatcagatg ctggatcaga   1020

ctttactgga gttaaacaac atgtgaaaac ctccttagct gcgaccacat tctttcgttt   1080

tgttttgttt tgtttttaaa cacctgctta ccccttaaat gcaatttatt tacttttacc   1140

actgtcacag aaacatccac aagataccag ctaggtcagg gggtggggaa aacacataca   1200

aaaaggcaag cccatgtcag ggcgatcctg gttcaaatgt gccatttccc gggttgatgc   1260

tgccacactt tgtagagagt ttagcaacac agtgtgctta gtcagcgtag gaatcctcac   1320

taaagcagaa gaagttccat tcaaagtgcc aatgatagag tcaacaggaa ggttaatgtt   1380

ggaaacacaa tcaggtgtgg attggtgcta ctttgaacaa aaggtccccc tgtggtcttt   1440

tgttcaacat tgtacaatgt agaactctgt ccaacactaa tttattttgt cttgagtttt   1500

actacaagat gagactatgg atcccgcatg cctgaattca ctaaagccaa gggtctgtaa   1560

gccacgctgc tcttccgaga cttccattcc tttctgattg gcacacgtgc agctcatgac   1620

aatctgtagg ataacaatca gtgtggattt ccactctttt cagtccttca tgttaaagat   1680

ttagacacca catacaactg gtaaaggacg ttttcttgag agttttaact atatgtaaac   1740

attgtataat gatatggaat aaaatgcaca ttgtaggaca ttttctaaaa aaaaaaa      1797


<210>  3261
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  3261

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Glu Asp Ile Ala Ala Lys Glu Lys 
        35                  40                  45              


Leu Leu Arg Val Ser Glu Asp Glu Arg Asp Arg Val Leu Glu Glu Leu 
    50                  55                  60                  


His Lys Ala Glu Asp Ser Leu Leu Ala Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Glu Lys Val Ala His Ala Lys Glu Glu Asn Leu Ser Met His Gln 
            260                 265                 270         


Met Leu Asp Gln Thr Leu Leu Glu Leu Asn Asn Met 
        275                 280                 


<210>  3262
<211>  1566
<212>  DNA
<213>  Homosapiens

<400>  3262
ggggcgccgc catcgcacag agaggcctgg gcggggcgga ccggcgctgg gcagccagga     60

cagccgcggc agccgggtcc gcagggcagc agccggcctc tcccactgca gccctcccgc    120

ccgcctaccg tccggcgcga tggcggggag tagctcgctg gaggcggtgc gcaggaagat    180

ccggagcctg caggagcagg cggacgccgc tgaggagcgc gcgggcaccc tgcagcgcga    240

gctggaccac gagaggaagc tgagggagac cgctgaagcc gacgtagctt ctctgaacag    300

acgcatccag ctggttgagg aagagttgga tcgtgcccag gagcgtctgg caacagcttt    360

gcagaagctg gaggaagctg agaaggcagc agatgagagt gagagaggca tgaaagtcat    420

tgagagtcga gcccaaaaag atgaagaaaa aatggaaatt caggagatcc aactgaaaga    480

ggccaagcac attgctgaag atgccgaccg caaatatgaa gaggtggccc gtaagctggt    540

catcattgag agcgacctgg aacgtgcaga ggagcgggct gagctctcag aaggcaaatg    600

tgccgagctt gaagaagaat tgaaaactgt gacgaacaac ttgaagtcac tggaggctca    660

ggctgagaag tactcgcaga aggaagacag atatgaggaa gagatcaagg tcctttccga    720

caagctgaag gaggctgaga ctcgggctga gtttgcggag aggtcagtaa ctaaattgga    780

gaaaagcatt gatgacttag aagatcaact ctaccagcaa cttgagcaaa atcgccgcct    840

cactaatgaa ctaaagctgg ccctgaatga ggattaaact taagagtgaa aaaacttggg    900

ctgaattcta ggcgtggagc ccatgtgcag aaaatctaag actgtcctac cttcaactaa    960

tagagttgaa aacagttgct ttctgcagaa atgcaaatgc aaggaattgg ctgaaaggct   1020

ggccttgcct gcttgtttct ctatatggct ggaataatta cgttctcttt aatcacaaaa   1080

cagcttttat ggtagaatac ttatatcaat tcagcactgc tccttgaaat agcaggtcct   1140

cttgtttgaa ctgataaata atgaggagcc cccccaaaaa atgttttcta tttcctgaca   1200

gccatgagtc ctactttaag tatgtatata tatatatata tgtgtgtgtg tgtgtgtgtg   1260

tatatattcc tatcagatac tcatattcct aacttctaaa tatctggtat agtgtttgaa   1320

atatgattaa atgtacctat gcttgggcaa aatagctttt gaaaacagga actcatgcca   1380

gaagcccctg gttgtctgaa aggtatgctt tactcagtct aatggtgctg ttggagtctg   1440

gggagaatgt catgctaata aatagaacac tataaaaata ttaagagaat gtcctaatga   1500

agtgtgcatg aaacatgttg acaatttttt atgagcaaca gaaataaatc attttaaaag   1560

ttctca                                                              1566


<210>  3263
<211>  245
<212>  PRT
<213>  Homosapiens

<400>  3263

Met Ala Gly Ser Ser Ser Leu Glu Ala Val Arg Arg Lys Ile Arg Ser 
1               5                   10                  15      


Leu Gln Glu Gln Ala Asp Ala Ala Glu Glu Arg Ala Gly Thr Leu Gln 
            20                  25                  30          


Arg Glu Leu Asp His Glu Arg Lys Leu Arg Glu Thr Ala Glu Ala Asp 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Ser 
                85                  90                  95      


Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu Glu Arg Ala Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu Ile Lys Val Leu 
            180                 185                 190         


Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu Glu Asp Gln Leu 
    210                 215                 220                 


Tyr Gln Gln Leu Glu Gln Asn Arg Arg Leu Thr Asn Glu Leu Lys Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Asp 
                245 


<210>  3264
<211>  1797
<212>  DNA
<213>  Homosapiens

<400>  3264
ggaagggggg caggagaaaa aagcttttcc aaaaaagtat tggctgtctt gaggaatgcg     60

gtcgccccct tgggaaagta catatctggg agaagcaggc ggctccgcgc tcgcactccc    120

gctcctccgc ccgaccgcgc gctcgccccg ccgctcctgc tgcagcccca gggcccctcg    180

ccgccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc gacaaggaga    240

acgccttgga tcgagctgag caggcggagg ccgacaagaa ggcggcggaa gacaggagca    300

agcagctcga ggaggacatc gcggccaagg agaagttgct gcgggtgtcg gaggacgagc    360

gggaccgggt gctggaggag ctgcacaagg cggaggacag cctcctggcc gccgaagagg    420

ccgccgccaa ggctgaagcc gacgtagctt ctctgaacag acgcatccag ctggttgagg    480

aagagttgga tcgtgcccag gagcgtctgg caacagcttt gcagaagctg gaggaagctg    540

agaaggcagc agatgagagt gagagaggca tgaaagtcat tgagagtcga gcccaaaaag    600

atgaagaaaa aatggaaatt caggagatcc aactgaaaga ggccaagcac attgctgaag    660

atgccgaccg caaatatgaa gaggtggccc gtaagctggt catcattgag agcgacctgg    720

aacgtgcaga ggagcgggct gagctctcag aaggccaagt ccgacagctg gaagaacaat    780

taagaataat ggatcagacc ttgaaagcat taatggctgc agaggataag tactcgcaga    840

aggaagacag atatgaggaa gagatcaagg tcctttccga caagctgaag gaggctgaga    900

ctcgggctga gtttgcggag aggtcagtaa ctaaattgga gaaaagcatt gatgacttag    960

aagagaaagt ggctcatgcc aaagaagaaa accttagtat gcatcagatg ctggatcaga   1020

ctttactgga gttaaacaac atgtgaaaac ctccttagct gcgaccacat tctttcgttt   1080

tgttttgttt tgtttttaaa cacctgctta ccccttaaat gcaatttatt tacttttacc   1140

actgtcacag aaacatccac aagataccag ctaggtcagg gggtggggaa aacacataca   1200

aaaaggcaag cccatgtcag ggcgatcctg gttcaaatgt gccatttccc gggttgatgc   1260

tgccacactt tgtagagagt ttagcaacac agtgtgctta gtcagcgtag gaatcctcac   1320

taaagcagaa gaagttccat tcaaagtgcc aatgatagag tcaacaggaa ggttaatgtt   1380

ggaaacacaa tcaggtgtgg attggtgcta ctttgaacaa aaggtccccc tgtggtcttt   1440

tgttcaacat tgtacaatgt agaactctgt ccaacactaa tttattttgt cttgagtttt   1500

actacaagat gagactatgg atcccgcatg cctgaattca ctaaagccaa gggtctgtaa   1560

gccacgctgc tcttccgaga cttccattcc tttctgattg gcacacgtgc agctcatgac   1620

aatctgtagg ataacaatca gtgtggattt ccactctttt cagtccttca tgttaaagat   1680

ttagacacca catacaactg gtaaaggacg ttttcttgag agttttaact atatgtaaac   1740

attgtataat gatatggaat aaaatgcaca ttgtaggaca ttttctaaaa aaaaaaa      1797


<210>  3265
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  3265

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Glu Asp Ile Ala Ala Lys Glu Lys 
        35                  40                  45              


Leu Leu Arg Val Ser Glu Asp Glu Arg Asp Arg Val Leu Glu Glu Leu 
    50                  55                  60                  


His Lys Ala Glu Asp Ser Leu Leu Ala Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Gln Val Arg Gln 
            180                 185                 190         


Leu Glu Glu Gln Leu Arg Ile Met Asp Gln Thr Leu Lys Ala Leu Met 
        195                 200                 205             


Ala Ala Glu Asp Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Glu Lys Val Ala His Ala Lys Glu Glu Asn Leu Ser Met His Gln 
            260                 265                 270         


Met Leu Asp Gln Thr Leu Leu Glu Leu Asn Asn Met 
        275                 280                 


<210>  3266
<211>  1956
<212>  DNA
<213>  Homosapiens

<400>  3266
gtgcgtgagt ttggtggcgg ccggctgtgc agagacgcca tgtaccggct catgtcagca     60

gtgactgccc gggctgccgc ccccgggggc ttggcctcaa gctgcggacg acgcggggtc    120

catcagcgcg ccgggctgcc gcctctcggc cacggctggg tcgggggcct cgggctgggg    180

ctggggctgg cgctcggggt gaagctggca ggtgggctga ggggcgcggc cccggcgcag    240

tcccccgcgg cccccgaccc tgaggcgtcg cctctggccg agccgccaca ggagcagtcc    300

ctcgccccgt ggtctccgca gaccccggcg ccgccctgct ccaggtgctt cgccagagcc    360

atcgagagca gccgcgacct gctgcacagg atcaaggatg aggtgggcgc accgggcata    420

gtggttggag tttctgtaga tggaaaagaa gtctggtcag aaggtttagg ttatgctgat    480

gttgagaacc gtgtaccatg taaaccagag acagttatgc gaattgctag catcagcaaa    540

agtctcacca tggttgctct tgccaaattg tgggaagcag ggaaactgga tcttgatatt    600

ccagtacaac attatgttcc cgaattccca gaaaaagaat atgaaggtga aaaggtttct    660

gtcacaacaa gattactgat ttcccattta agtggaattc gtcattatga aaaggacata    720

aaaaaggtga aagaagagaa agcttataaa gccttgaaga tgatgaaaga gaatgttgca    780

tttgagcaag aaaaagaagg caaaagtaat gaaaagaatg attttactaa atttaaaaca    840

gagcaggaga atgaagccaa atgccggaat tcaaaacctg gcaagaaaaa gaatgatttt    900

gaacaaggcg aattatattt gagagaaaag tttgaaaatt caattgaatc cctaagatta    960

tttaaaaatg atcctttgtt cttcaaacct ggtagtcagt ttttgtattc aacttttggc   1020

tataccctac tggcagccat agtagagaga gcttcaggat gtaaatattt ggactatatg   1080

cagaaaatat tccatgactt ggatatgctg acgactgtgc aggaagaaaa cgagccagtg   1140

atttacaata gagcaagatt ttatgtttac aataaaaaga aacgtcttgt caacacacct   1200

tacgtggata actcctataa atgggctggt ggtggatttc tgtctacagt gggtgacctt   1260

ctgaaatttg ggaatgcaat gctttatggt taccaagttg ggctgtttaa gaactcaaat   1320

gaaaatcttt tacctggata cctcaaacca gaaacaatgg ttatgatgtg gaccccagtc   1380

cctaacacag agatgtcttg ggataaagag ggtaaatatg caatggcgtg gggtgttgtg   1440

gaaaggaaac aaacgtatgg ttcgtgtaga aagcaacggc attatgcttc acatactgga   1500

ggggcagtgg gtgccagtag tgtcctgctg gtccttcctg aagaactgga tacagagact   1560

ataaataaca aggttccccc aagaggaatc attgtttcta tcatatgtaa catgcaatct   1620

gttggcctca atagcaccgc tttgaagatt gcccttgaat ttgataaaga cagatcagac   1680

tgataacctt aacaccatag gtgcaaaatg agttgttctg aggttttttt gaaacattaa   1740

agttccaaaa catgacattt ttaagaataa atttgaaata gagtataact gaatgcagag   1800

aattatgtac ctctaattgc ttaattttgt aatggtcttt tattgtagaa ttggttcttt   1860

atactcaggg aagtaattat attgttttta ctttttgaaa aaagtgttaa ctcttgaaat   1920

aaaatattct gataaaataa aaaaaaaaaa aaaaaa                             1956


<210>  3267
<211>  547
<212>  PRT
<213>  Homosapiens

<400>  3267

Met Tyr Arg Leu Met Ser Ala Val Thr Ala Arg Ala Ala Ala Pro Gly 
1               5                   10                  15      


Gly Leu Ala Ser Ser Cys Gly Arg Arg Gly Val His Gln Arg Ala Gly 
            20                  25                  30          


Leu Pro Pro Leu Gly His Gly Trp Val Gly Gly Leu Gly Leu Gly Leu 
        35                  40                  45              


Gly Leu Ala Leu Gly Val Lys Leu Ala Gly Gly Leu Arg Gly Ala Ala 
    50                  55                  60                  


Pro Ala Gln Ser Pro Ala Ala Pro Asp Pro Glu Ala Ser Pro Leu Ala 
65                  70                  75                  80  


Glu Pro Pro Gln Glu Gln Ser Leu Ala Pro Trp Ser Pro Gln Thr Pro 
                85                  90                  95      


Ala Pro Pro Cys Ser Arg Cys Phe Ala Arg Ala Ile Glu Ser Ser Arg 
            100                 105                 110         


Asp Leu Leu His Arg Ile Lys Asp Glu Val Gly Ala Pro Gly Ile Val 
        115                 120                 125             


Val Gly Val Ser Val Asp Gly Lys Glu Val Trp Ser Glu Gly Leu Gly 
    130                 135                 140                 


Tyr Ala Asp Val Glu Asn Arg Val Pro Cys Lys Pro Glu Thr Val Met 
145                 150                 155                 160 


Arg Ile Ala Ser Ile Ser Lys Ser Leu Thr Met Val Ala Leu Ala Lys 
                165                 170                 175     


Leu Trp Glu Ala Gly Lys Leu Asp Leu Asp Ile Pro Val Gln His Tyr 
            180                 185                 190         


Val Pro Glu Phe Pro Glu Lys Glu Tyr Glu Gly Glu Lys Val Ser Val 
        195                 200                 205             


Thr Thr Arg Leu Leu Ile Ser His Leu Ser Gly Ile Arg His Tyr Glu 
    210                 215                 220                 


Lys Asp Ile Lys Lys Val Lys Glu Glu Lys Ala Tyr Lys Ala Leu Lys 
225                 230                 235                 240 


Met Met Lys Glu Asn Val Ala Phe Glu Gln Glu Lys Glu Gly Lys Ser 
                245                 250                 255     


Asn Glu Lys Asn Asp Phe Thr Lys Phe Lys Thr Glu Gln Glu Asn Glu 
            260                 265                 270         


Ala Lys Cys Arg Asn Ser Lys Pro Gly Lys Lys Lys Asn Asp Phe Glu 
        275                 280                 285             


Gln Gly Glu Leu Tyr Leu Arg Glu Lys Phe Glu Asn Ser Ile Glu Ser 
    290                 295                 300                 


Leu Arg Leu Phe Lys Asn Asp Pro Leu Phe Phe Lys Pro Gly Ser Gln 
305                 310                 315                 320 


Phe Leu Tyr Ser Thr Phe Gly Tyr Thr Leu Leu Ala Ala Ile Val Glu 
                325                 330                 335     


Arg Ala Ser Gly Cys Lys Tyr Leu Asp Tyr Met Gln Lys Ile Phe His 
            340                 345                 350         


Asp Leu Asp Met Leu Thr Thr Val Gln Glu Glu Asn Glu Pro Val Ile 
        355                 360                 365             


Tyr Asn Arg Ala Arg Phe Tyr Val Tyr Asn Lys Lys Lys Arg Leu Val 
    370                 375                 380                 


Asn Thr Pro Tyr Val Asp Asn Ser Tyr Lys Trp Ala Gly Gly Gly Phe 
385                 390                 395                 400 


Leu Ser Thr Val Gly Asp Leu Leu Lys Phe Gly Asn Ala Met Leu Tyr 
                405                 410                 415     


Gly Tyr Gln Val Gly Leu Phe Lys Asn Ser Asn Glu Asn Leu Leu Pro 
            420                 425                 430         


Gly Tyr Leu Lys Pro Glu Thr Met Val Met Met Trp Thr Pro Val Pro 
        435                 440                 445             


Asn Thr Glu Met Ser Trp Asp Lys Glu Gly Lys Tyr Ala Met Ala Trp 
    450                 455                 460                 


Gly Val Val Glu Arg Lys Gln Thr Tyr Gly Ser Cys Arg Lys Gln Arg 
465                 470                 475                 480 


His Tyr Ala Ser His Thr Gly Gly Ala Val Gly Ala Ser Ser Val Leu 
                485                 490                 495     


Leu Val Leu Pro Glu Glu Leu Asp Thr Glu Thr Ile Asn Asn Lys Val 
            500                 505                 510         


Pro Pro Arg Gly Ile Ile Val Ser Ile Ile Cys Asn Met Gln Ser Val 
        515                 520                 525             


Gly Leu Asn Ser Thr Ala Leu Lys Ile Ala Leu Glu Phe Asp Lys Asp 
    530                 535                 540                 


Arg Ser Asp 
545         


<210>  3268
<211>  1388
<212>  DNA
<213>  Homosapiens

<400>  3268
gtgcgtgagt ttggtggcgg ccggctgtgc agagacgcca tgtaccggct catgtcagca     60

gtgactgccc gggctgccgc ccccgggggc ttggcctcaa gctgcggacg acgcggggtc    120

catcagcgcg ccgggctgcc gcctctcggc cacggctggg tcgggggcct cgggctgggg    180

ctggggctgg cgctcggggt gaagctggca ggtgggctga ggggcgcggc cccggcgcag    240

tcccccgcgg cccccgaccc tgaggcgtcg cctctggccg agccgccaca ggagcagtcc    300

ctcgccccgt ggtctccgca gaccccggcg ccgccctgct ccaggtgctt cgccagagcc    360

atcgagagca gccgcgacct gctgcacagg atcaaggatg aggtgggcgc accgggcata    420

gtggttggag tttctgtaga tggaaaagaa gtctggtcag aaggtttagg ttatgctgat    480

gttgagaacc gtgtaccatg taaaccagag acagttatgc gaattgctag catcagcaaa    540

agtctcacca tggttgctct tgccaaattg tgggaagcag ggaaactgga tcttgatatt    600

ccagtacaac attatgttcc cgaattccca gaaaaagaat atgaaggtga aaaggtttct    660

gtcacaacaa gattactgat ttcccattta agtggaattc gtcattatga aaaggacata    720

aaaaaggtga aagaagagaa agcttataaa gccttgaaga tgatgaaaga gaatgttgca    780

tttgagcaag aaaaagaagg caaaagtaat gaaaagaatg attttactaa atttaaaaca    840

gagcaggaga atgaagccaa atgccggaat tcaaaacctg gcaagaaaaa gaatgatttt    900

gaacaaggcg aattatattt gagagaaaag tttgaaaatt caattgaatc cctaagatta    960

tttaaaaatg atcctttgtt cttcaaacct ggtagtcagt ttttgtattc aacttttggc   1020

tataccctac tggcagccat agtagagaga gcttcaggat gtaaatattt ggactatatg   1080

cagaaaatat tccatgactt ggatatgctg acgactgtgc aggaagaaaa cgagccagtg   1140

atttacaata gagcaaggta aatgaatacc ttctgctgtg tctagctata tcgcatctta   1200

acactatttt attaattaaa agtcaaattt tctttgtttc cattccaaaa tcaacctgcc   1260

acattttggg agcttttcta catgtctgtt ttctcatctg taaagtgaag gaagtaaaac   1320

atgtttataa agtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1380

aaaaaaaa                                                            1388


<210>  3269
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  3269

Met Tyr Arg Leu Met Ser Ala Val Thr Ala Arg Ala Ala Ala Pro Gly 
1               5                   10                  15      


Gly Leu Ala Ser Ser Cys Gly Arg Arg Gly Val His Gln Arg Ala Gly 
            20                  25                  30          


Leu Pro Pro Leu Gly His Gly Trp Val Gly Gly Leu Gly Leu Gly Leu 
        35                  40                  45              


Gly Leu Ala Leu Gly Val Lys Leu Ala Gly Gly Leu Arg Gly Ala Ala 
    50                  55                  60                  


Pro Ala Gln Ser Pro Ala Ala Pro Asp Pro Glu Ala Ser Pro Leu Ala 
65                  70                  75                  80  


Glu Pro Pro Gln Glu Gln Ser Leu Ala Pro Trp Ser Pro Gln Thr Pro 
                85                  90                  95      


Ala Pro Pro Cys Ser Arg Cys Phe Ala Arg Ala Ile Glu Ser Ser Arg 
            100                 105                 110         


Asp Leu Leu His Arg Ile Lys Asp Glu Val Gly Ala Pro Gly Ile Val 
        115                 120                 125             


Val Gly Val Ser Val Asp Gly Lys Glu Val Trp Ser Glu Gly Leu Gly 
    130                 135                 140                 


Tyr Ala Asp Val Glu Asn Arg Val Pro Cys Lys Pro Glu Thr Val Met 
145                 150                 155                 160 


Arg Ile Ala Ser Ile Ser Lys Ser Leu Thr Met Val Ala Leu Ala Lys 
                165                 170                 175     


Leu Trp Glu Ala Gly Lys Leu Asp Leu Asp Ile Pro Val Gln His Tyr 
            180                 185                 190         


Val Pro Glu Phe Pro Glu Lys Glu Tyr Glu Gly Glu Lys Val Ser Val 
        195                 200                 205             


Thr Thr Arg Leu Leu Ile Ser His Leu Ser Gly Ile Arg His Tyr Glu 
    210                 215                 220                 


Lys Asp Ile Lys Lys Val Lys Glu Glu Lys Ala Tyr Lys Ala Leu Lys 
225                 230                 235                 240 


Met Met Lys Glu Asn Val Ala Phe Glu Gln Glu Lys Glu Gly Lys Ser 
                245                 250                 255     


Asn Glu Lys Asn Asp Phe Thr Lys Phe Lys Thr Glu Gln Glu Asn Glu 
            260                 265                 270         


Ala Lys Cys Arg Asn Ser Lys Pro Gly Lys Lys Lys Asn Asp Phe Glu 
        275                 280                 285             


Gln Gly Glu Leu Tyr Leu Arg Glu Lys Phe Glu Asn Ser Ile Glu Ser 
    290                 295                 300                 


Leu Arg Leu Phe Lys Asn Asp Pro Leu Phe Phe Lys Pro Gly Ser Gln 
305                 310                 315                 320 


Phe Leu Tyr Ser Thr Phe Gly Tyr Thr Leu Leu Ala Ala Ile Val Glu 
                325                 330                 335     


Arg Ala Ser Gly Cys Lys Tyr Leu Asp Tyr Met Gln Lys Ile Phe His 
            340                 345                 350         


Asp Leu Asp Met Leu Thr Thr Val Gln Glu Glu Asn Glu Pro Val Ile 
        355                 360                 365             


Tyr Asn Arg Ala Arg 
    370             


<210>  3270
<211>  1084
<212>  DNA
<213>  Homosapiens

<400>  3270
tagagcagac aagcccgccc cgccgctcct cccagcagct tctatcccgg aagttgatgc     60

cgagcgcaga tcgcttgcag cttgctagct gtgtgggctg ggaggtctgg tagggctgag    120

cttgcaagag gatcaacatg cctttggcta gagatttact acatccgtcc ttggaagagg    180

aaaagaaaaa acataaaaag aaacgcctag tacaaagtcc aaattcttac tttatggatg    240

taaaatgtcc aggttgctac aagatcacca cggttttcag ccatgctcag acagtggttc    300

tttgtgtagg ttgttcaaca gtgttgtgcc agcctacagg aggaaaggcc agactcacag    360

aagggtgttc atttagaaga aagcaacact aatgattcaa acagcttcct gaattttaat    420

tttgtgttgt ctcacagaaa gccttatcat aaattccata attctaatta atttaccaag    480

ataatgtaat tacatttggt tttgtaaggt atacagcagt aatctcctat tttggtgtca    540

gtttttcaat aaagttttga ttatgggcaa atcccctctt tttctttttt taaaatatat    600

ttgagtatgc catacattta tatatatggt gtatatgaat ttggtttaaa cattttaaaa    660

tttattctga ttagtttgtg tctttttttt tttttttgag agagagagtc ctgctctgtc    720

actcaagctg gagtgcagtg gtgcgatctc ggctcactgc aacctccgcc tcccaggtcc    780

aagcaattct cttgccttgt cctcccaagt agctgggatt ataggcacac accaccatgc    840

ctggctaatt tgtgtctcat tttcaagagt agaaacccta aatattttat tttcattcct    900

tttccaaatt gctatgaatg ggattaaagg attacagatg taaagtctat tatttgtgaa    960

ttctaaatgt agttctgctg ttgtacctgt ggaaacatct taaagaagta catattttgc   1020

acgtcctgca cgtgtacccc agaacttaaa ctataattaa aaagaatagt ttcaaaaaaa   1080

taca                                                                1084


<210>  3271
<211>  84
<212>  PRT
<213>  Homosapiens

<400>  3271

Met Pro Leu Ala Arg Asp Leu Leu His Pro Ser Leu Glu Glu Glu Lys 
1               5                   10                  15      


Lys Lys His Lys Lys Lys Arg Leu Val Gln Ser Pro Asn Ser Tyr Phe 
            20                  25                  30          


Met Asp Val Lys Cys Pro Gly Cys Tyr Lys Ile Thr Thr Val Phe Ser 
        35                  40                  45              


His Ala Gln Thr Val Val Leu Cys Val Gly Cys Ser Thr Val Leu Cys 
    50                  55                  60                  


Gln Pro Thr Gly Gly Lys Ala Arg Leu Thr Glu Gly Cys Ser Phe Arg 
65                  70                  75                  80  


Arg Lys Gln His 
                


<210>  3272
<211>  4877
<212>  DNA
<213>  Homosapiens

<400>  3272
ggcggattgg cgggcacgcc ccctcgcccg cggccccctc cccgcctctc tccaccgcct     60

cctctggctc cccggtcaga gggccggagc gagaagatgg cgaagacgta cgattatctc    120

ttcaagctcc tgctgatcgg cgactcgggg gtaggcaaga cctgcctcct gttccgcttc    180

tcagaggacg ccttcaacac caccttcatc tccaccatcg gaattgattt taaaattaga    240

acgatagaac tagatggaaa gaaaattaag cttcagatat gggacacagc gggtcaggaa    300

agattccgaa caatcacgac agcgtactac agaggagcca tgggcattat gctggtctat    360

gacatcacaa atgaaaaatc ctttgacaat attaaaaatt ggatcagaaa cattgaagag    420

catgcctctt ccgatgtcga aagaatgatc ctgggtaaca aatgtgatat gaatgacaaa    480

agacaagtgt caaaagaaag aggggagaag ctagcaattg actatgggat taaattcttg    540

gagacaagcg caaaatccag tgcaaatgta gaagaggcat tttttacact tgcacgagat    600

ataatgacaa aactcaacag aaaaatgaat gacagcaatt cagcaggagc aggtggacca    660

gtgaaaataa cagaaaaccg atcaaagaag accagtttct ttcgttgctc gctactttga    720

tgaactcttt ctgagagact gcagcacacc tagagggccc tttcctgctt ctctgaaagc    780

acaggtcacc cagcctcaga atcacacctc ccggctgctg ctgagagcac cactgaactt    840

agacctctca acacagtatg ccaagtggat tccagcctca tggcctagca aaagaacaga    900

ctcccttttt caaacatgga agcaatgaag tggagacaca tgcaggacct aactcgtttt    960

ttccttgttt tattacctgt tgcagaagcg gttatctttc ttttttactt tgcacatcag   1020

tgttagcctt tccctatttc agcacaatct tagactcata tttgcacact tttgtgtcgt   1080

gaagttctag acaaatttgt acatgtggca atgttaaaag agcatttaca gcagaggtta   1140

atatactaaa attaaagggt atttggtctg gttcatatgg tcaaatatta ctgccttggt   1200

agcatttatt taagggcttt ttcttaaata agaatcatta aagtcattaa aaaaatttac   1260

tgaaatgccc atcttgtcat caaaggccac aatttcttta tttcttcaga ttaagagctt   1320

tgcctcatcc ccgacctgtt ttccagagtc tgggtagctg aatgaatcac tttaaaatga   1380

ttacctctgc ctaatctata gaaactgcat ttggaaatca ccataatctc atttttccct   1440

ggggtttgta tttgctattc tttcccatgt ttgacttaag tgtaatcact cttaagtaat   1500

atttgaacat tattatctgt ttctatttgt gaacttcttg agctgaaatt ttacgtgggc   1560

tgagagatat accatttagg gttttagtgc agcatctaac tgtgattctg tcaataagga   1620

tatgtaatat attttttctt aggttcactc cttagctggc tggtttagtt gtaataccaa   1680

attcctacca taatccctgt ctacaaaagt taggtttaga ttttagtttg cggaaacctt   1740

ccctatatag agacagatta acttgttgat ataaatttaa tagagctagc tcttggtaat   1800

ggtgaaaata atgagttttg gttggtttta tttggcagat gtttttagaa ataaaagtac   1860

ttagacctag tgcagcctct aggaaaagtc ttgccttttc attagagaaa acaggaccaa   1920

ggtttcagtt ttcaaacagc tgttgttgat tgtgtagaac ccagttccat ctgttttggt   1980

tcattgttac agaacttagt ccagtcattt gggctaaagc caaccaaaag cttagttgcc   2040

tttctcaaca aacactggta ctggtatact tttgtagatg aaaccatcac aaggtattta   2100

gtgttaactt gtgtgccaaa ttcagatcac tatgtcgttg ttgctctagc cttcagtgtc   2160

ataacacagg ggggataaaa cagaggggat gagggaaatg aattctgtta ataattattc   2220

ttcctggtat gcctgttttg cttcacaaag gctactatca tgctggatag ataagaacag   2280

gagatggcag tggaaaggga ttgcttgtta ccacagagaa ttctcttcaa attaagatat   2340

gtcattagaa tgcttggacc agtcaatctt ttgtacttat ttgaaaatat aggaacaatt   2400

tagcagctgc aaatatgccc aagctatttt taatagatat actaaactta ttgttgacaa   2460

atttcagcct ccttaatttt tttttttttg gtaattacct ataggcttaa aagtcattcg   2520

ttgctgttct agtataatta gtagttccgt gattgaaagt ttattgtaat tctactatct   2580

tcaaattaga tacattttca aaaggaaaag ataatttttt agaaacatct taatattcac   2640

tatttcctga aaaaatccaa gcagttaacg ctttctggat ggtaacaaag taccttctaa   2700

aagataagtg ctatgacacc atgtatgaat gtaattctct tagtaattta cctctgacta   2760

tttggtgtct taacgctttg gtttatataa tctcaggggt tgtctgcaaa ccaaaactga   2820

catattctgt ggttagcttt tattactttt ttttttaaca gaatgctttg ctttggttat   2880

atttcttctt tcttcttttg tcttatatgg attaataact agtctccatg aacttcactt   2940

gaaagagcct gtaaaagtta gatgagtcta aaagtgctct ttgaagtagc agcaaattgg   3000

gagtatatgc tctgttatat agaaataaat tgtccttgct attttcttac atttagcttt   3060

gctagattgt atatacattg agctaagacc ttaggaaatt cactttctgc atgataaaat   3120

gacccaataa atattccact ttgcttaata atgtacatac agtgcattat tttttctatt   3180

tgtagatgaa tttaatgaca gataattgtc tgttccccgc tgaaactgaa gaaatctagt   3240

ttttttgtga acatttttgt ggtcttatgg ataaggtaca tgaagatttt tgcagcagta   3300

ttagtggttc agtggctgca ctttattaat cagtgtgtta atttttgaca gtgattggac   3360

tagacctttt caaatagagt ctgagggtat cagacagtga aaatgtgctg taactaagta   3420

gcatgtaaat cagttgattg taaaacgttt cgctgggaac ttattttagc tatattttac   3480

ttcagacaga ttatgataca ataatctacc tgtgcatcag ttagtaggtg ctgcagggtt   3540

tcttactatt tacagaaaca ttttgtgcag tctttgttat aaattttcag aagactatac   3600

tctttacttt gaaggtctat tttttaatta tacctcattt agctaactag tattctaata   3660

cctggtagaa aaacagtgag ccagccttta agcatctaac aaaatttaga ctctttgttt   3720

tgttttgaac tgaagacatc attgggaaag gtaggaaata ttagtttagg atagagcata   3780

catgtcatat ccagtagcat aaaaaaagta ttatctccct gtctccatta ataaatttag   3840

ctgtgcaata taggtgcgtt tttgcagaag tttctagtaa gagattataa ctccatttta   3900

caggttctga atgctcagag tctatattaa ggcttataaa gtttttcctg tgatcagtaa   3960

gtgacacatt taagcagaca ttcttttcaa gttcatgact tagattcctt tacaaattta   4020

gttctcaatc tttaaaaacc acatttcatt atgttggtta attattataa attttaagca   4080

ctcatttctg caatcaggtt tctcagaatt tttttttttt aaacagaaga gacattcctt   4140

tttccttgtt acatccaagg ggggcacagg ggtgggtgga aaggaatgtc taaaaatgaa   4200

atcccttgat atagagggac ctagacggac aggatatgct aaaataattt caaattctag   4260

cacaatttta gagtagaata agtcattttt ttagactaat aaaattaatg gctgtcatgt   4320

tcactctgaa aaaaatctaa atgactgaaa tgtacagaaa taaaaattag caaacaatta   4380

ttctagggat attttcagat tttacttcat ttcttgaaat gcgtgtgcca tatgcaattg   4440

catttcttgt gccaagaaac taatagaact tatttcactt tacctttttt taaaatgtga   4500

atttagttat tatagttcaa ttttatggcc ttacagatgg cttttatttt gtttgcagct   4560

gacactgcag ttcctttcat gcaaaatacc ataaactgtt tgatgaaaat catgccccta   4620

atggaaactc tctagttttt ccatataact atcctactgt acatgtttaa acatatttta   4680

tttttgctcc aatggcttaa tgtgaaaagc tcctgcagat aagtggacct gtcatgtggt   4740

taatcttgtt taagccaatt cattaactgt gtactgatac tgatgctatg ttttttttaa   4800

atggatttta ttccaggtga actttttttt tataataatg ttcgtctaaa ataaaaacta   4860

cataatgaaa atgaaaa                                                  4877


<210>  3273
<211>  207
<212>  PRT
<213>  Homosapiens

<400>  3273

Met Ala Lys Thr Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Cys Leu Leu Phe Arg Phe Ser Glu Asp Ala 
            20                  25                  30          


Phe Asn Thr Thr Phe Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile Arg 
        35                  40                  45              


Thr Ile Glu Leu Asp Gly Lys Lys Ile Lys Leu Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala Met Gly Ile Met Leu Val Tyr Asp Ile Thr Asn Glu Lys Ser Phe 
                85                  90                  95      


Asp Asn Ile Lys Asn Trp Ile Arg Asn Ile Glu Glu His Ala Ser Ser 
            100                 105                 110         


Asp Val Glu Arg Met Ile Leu Gly Asn Lys Cys Asp Met Asn Asp Lys 
        115                 120                 125             


Arg Gln Val Ser Lys Glu Arg Gly Glu Lys Leu Ala Ile Asp Tyr Gly 
    130                 135                 140                 


Ile Lys Phe Leu Glu Thr Ser Ala Lys Ser Ser Ala Asn Val Glu Glu 
145                 150                 155                 160 


Ala Phe Phe Thr Leu Ala Arg Asp Ile Met Thr Lys Leu Asn Arg Lys 
                165                 170                 175     


Met Asn Asp Ser Asn Ser Ala Gly Ala Gly Gly Pro Val Lys Ile Thr 
            180                 185                 190         


Glu Asn Arg Ser Lys Lys Thr Ser Phe Phe Arg Cys Ser Leu Leu 
        195                 200                 205         


<210>  3274
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  3274
aacgggcccc cgggtcggtt tccgcggtgg ccatgactgc ggccgtgttc ttcggctgcg     60

ccttcattgc cttcgggcct gcgctcgccc tttatgtctt caccatcgcc accgagccgt    120

tgcgtatcat cttcctcatc gccggagctt tcttctggtt ggtgtctcta ctgatttcgt    180

cccttgtttg gttcatggca agagtcatta ttgacaacaa agatggacca acacagaaat    240

atctgctgat ctttggagcg tttgtctctg tctatatcca agaaatgttc cgatttgcat    300

attataaact cttaaaaaaa gccagtgaag gtttgaagag tataaaccca ggtgagacag    360

caccctctat gcgactgctg gcctatgttt ctggcttggg ctttggaatc atgagtggag    420

tattttcctt tgtgaatacc ctatctgact ccttggggcc aggcacagtg ggcattcatg    480

gagattctcc tcaattcttc ctttattcag ctttcatgac gctggtcatt atcttgctgc    540

atgtattctg gggcattgta ttttttgatg gctgtgagaa gaaaaagtgg ggcatcctcc    600

ttatcgttct cctgacccac ctgctggtgt cagcccagac cttcataagt tcttattatg    660

gaataaacct ggcgtcagca tttataatcc tggtgctcat gggcacctgg gcattcttag    720

ctgcgggagg cagctgccga agcctgaaac tctgcctgct ctgccaagac aagaactttc    780

ttctttacaa ccagcgctcc agataacctc agggaaccag cacttcccaa accgcagact    840

acatctttag aggaagcaca actgtgcctt tttctgaaaa tccctttttc tggtggaatt    900

gagaaagaaa taaaactatg cagatatgcg ttccattca                           939


<210>  3275
<211>  257
<212>  PRT
<213>  Homosapiens

<400>  3275

Met Thr Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Thr Ile Ala Thr Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Thr Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Gln Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Thr Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Val Ser Gly Leu Gly Phe Gly Ile Met Ser 
        115                 120                 125             


Gly Val Phe Ser Phe Val Asn Thr Leu Ser Asp Ser Leu Gly Pro Gly 
    130                 135                 140                 


Thr Val Gly Ile His Gly Asp Ser Pro Gln Phe Phe Leu Tyr Ser Ala 
145                 150                 155                 160 


Phe Met Thr Leu Val Ile Ile Leu Leu His Val Phe Trp Gly Ile Val 
                165                 170                 175     


Phe Phe Asp Gly Cys Glu Lys Lys Lys Trp Gly Ile Leu Leu Ile Val 
            180                 185                 190         


Leu Leu Thr His Leu Leu Val Ser Ala Gln Thr Phe Ile Ser Ser Tyr 
        195                 200                 205             


Tyr Gly Ile Asn Leu Ala Ser Ala Phe Ile Ile Leu Val Leu Met Gly 
    210                 215                 220                 


Thr Trp Ala Phe Leu Ala Ala Gly Gly Ser Cys Arg Ser Leu Lys Leu 
225                 230                 235                 240 


Cys Leu Leu Cys Gln Asp Lys Asn Phe Leu Leu Tyr Asn Gln Arg Ser 
                245                 250                 255     


Arg 
    


<210>  3276
<211>  3992
<212>  DNA
<213>  Homosapiens

<400>  3276
ataaaagctg cccggggaag ccaggagagc gaagggcgga cgtactcgcc acggcaccca     60

ggctgcgcgc acgcggtccc ggtgtgcagc tggagagcga gcggccaccg ggagcccccg    120

gcacagcccg cgcccgcccc gcaggagccc gcgaagatgc cccggcgcag cctgcacgcg    180

gcggccgtgc tcctgctggt gatcttaaag gaacagcctt ccagcccggc cccagtgaac    240

ggttccaagt ggacttattt tggtcctgat ggggagaata gctggtccaa gaagtacccg    300

tcgtgtgggg gcctgctgca gtcccccata gacctgcaca gtgacatcct ccagtatgac    360

gccagcctca cgcccctcga gttccaaggc tacaatctgt ctgccaacaa gcagtttctc    420

ctgaccaaca atggccattc agtgaagctg aacctgccct cggacatgca catccagggc    480

ctccagtctc gctacagtgc cacgcagctg cacctgcact gggggaaccc gaatgacccg    540

cacggctctg agcacaccgt cagcggacag cacttcgccg ccgagctgca cattgtccat    600

tataactcag acctttatcc tgacgccagc actgccagca acaagtcaga aggcctcgct    660

gtcctggctg ttctcattga gatgggctcc ttcaatccgt cctatgacaa gatcttcagt    720

caccttcaac atgtaaagta caaaggccag gaagcattcg tcccgggatt caacattgaa    780

gagctgcttc cggagaggac cgctgaatat taccgctacc gggggtccct gaccacaccc    840

ccttgcaacc ccactgtgct ctggacagtt ttccgaaacc ccgtgcaaat ttcccaggag    900

cagctgctgg ctttggagac agccctgtac tgcacacaca tggacgaccc ttcccccaga    960

gaaatgatca acaacttccg gcaggtccag aagttcgatg agaggctggt atacacctcc   1020

ttctcccaag tgcaagtctg tactgcggca ggactgagtc tgggcatcat cctctcactg   1080

gccctggctg gcattcttgg catctgtatt gtggtggtgg tgtccatttg gcttttcaga   1140

aggaagagta tcaaaaaagg tgataacaag ggagtcattt acaagccagc caccaagatg   1200

gagactgagg cccacgcttg aggtccccgg agctcccggg cacatccagg aaggaccttg   1260

ctttggaccc tacacacttc ggctctctgg acacttgcga cacctcaagg tgttctctgt   1320

agctcaatct gcaaacatgc caggcctcag ggatcctctg ctgggtgcct ccttgccttg   1380

ggaccatggc caccccagag ccatccgatc gatggatggg atgcactctc agaccaagca   1440

gcaggaattc aaagctgctt gctgtaactg tgtgagattg tgaagtggtc tgaattctgg   1500

aatcacaaac caagccatgc tggtgggcca ttaatggttg gaaaacactt tcatccgggg   1560

ctttgccaga gcgtgctttc aagtgtcctg gaaattctgc tgcttctcca agctttcaga   1620

caagaatgtg cactctctgc ttaggttttg cttgggaaac tcaacttctt tcctctggag   1680

acggggcatc tccctctgat ttccttctgc tatgacaaaa cctttaatct gcaccttaca   1740

actcggggac aaatggggac aggaaggatc aagttgtaga gagaaaaaga aaacaagaga   1800

tatacattgt gatatattag ggacactttc acagtcctgt cctctggatc acagacactg   1860

cacagacctt agggaatggc aggttcaagt tccacttctt ggtggggatg agaagggaga   1920

gagagctaga gggacaaaga gaatgagaag acatggatga tctgggagag tctcactttg   1980

gaatcagaat tggaatcaca ttctgtttat caagccataa tgtaaggaca gaataataca   2040

atattaagtc caaatccaac ctcctgtcag tggagcagtt atgttttata ctctacagat   2100

tttacaaata atgaggctgt tccttgaaaa tgtgttgttg ctgtgtcctg gaggagacat   2160

gagttccgag atgacccaat ctgcctttga atctggagga aataggcaga aacaaaatga   2220

ctgtagaact tattctctgt aggccaaatt tcatttcagc cacttctgca ggatccctac   2280

tgccaacctg gaatggagac ttttatctac ttctctctct ctgaagatgt caaatcgtgg   2340

tttagatcaa atatatttca agctataaaa gcaggaggtt atctgtgcag ggggctggca   2400

tcatgtattt aggggcaagt aataatggaa tgctactaag atactccata ttcttccccg   2460

aatcacacag acagtttctg acaggcgcaa ctcctccatt ttcctcccgc aggtgagaac   2520

cctgtggaga tgagtcagtg ccatgactga gaaggaaccg acccctagtt gagagcacct   2580

tgcagttccc cgagaacttt ctgattcaca gtctcatttt gacagcatga aatgtcctct   2640

tgaagcatag ctttttaaat atctttttcc ttctactcct ccctctgact ctaagaattc   2700

tctcttctgg aatcgcttga acccaggagg cggaggttgc agtaagccaa ggtcatgcca   2760

ctgcactcta gcctgggtga cagagcgaga ctccatctca aaaaaaaaaa aaaaaaaatt   2820

attctgtacc atcacaactt ttcacaacga tggcaagcct tatgtcttgg gagcctgttt   2880

tgctaggcaa agttacaagt gacctaatgg gagctcaaat gtgtgtgtgt ctctctgtgt   2940

gtttgtgtgt gtgtgtgcac tcaagacctc taacagcctc gaagcctggg gtggcatccc   3000

ggccttgcca ttagcatgcc tcatgcatca tcagatgaca aggacaaccc tcatgacgaa   3060

gcaacatgaa ttagggggcc tcttggcctt ggtccaaaat tgtcaatcag aaatgaacat   3120

aaaggactcc agagcagtgg gactgtctgt caaaagactc tgtatatctt ttgtggatga   3180

gttttgtgag agaacagaga gaccattgta cctggcacaa gggctgttca tgaaaaggga   3240

gacttactgg gaggtgcaag acagtggcat ttctcctctc ctcttgctgc tcagcacagc   3300

cctggattgc agccccgagg ctgagaccag acaaagcccg ggaggcagaa agatgctcca   3360

agaaccaaca ctatcaatgt ctttgcaaat cctcacagga ttcctgtggg tccagctttg   3420

gaactgggaa acctttcttc ggatccgcac tcattccact gatgccagct gcccctgaag   3480

gatgccagta ctgtggtgtg tgagtctcag cagccgccca cacgctccta actctgctgc   3540

atggcagatg cctaggtgga aatagcaaaa acaaggccca ggctggggcc agggccagag   3600

gggaaggccc tggattctca ctcatgtgag atcttgaatc tctttctttg ttctgtttgt   3660

ttagttagta tcatctggta aaatagttaa aaaacaacaa aaaactctgt atctgtttct   3720

agcatgtgct gcattgactc tattaatcac atttcaaatt caccctacat tcctctcctc   3780

ttcactagcc tctctgaagg tgtcctggcc agccctggag aagcactggt gtctgcagca   3840

cccctcagtt cctgtgcctc agcccacagg ccactgtgat aatggtctgt ttagcacttc   3900

tgtatttatt gtaagaatga ttataatgaa gatacacact gtaactacaa gaaattataa   3960

atgtttttca catcaaaaaa aaaaaaaaaa aa                                 3992


<210>  3277
<211>  354
<212>  PRT
<213>  Homosapiens

<400>  3277

Met Pro Arg Arg Ser Leu His Ala Ala Ala Val Leu Leu Leu Val Ile 
1               5                   10                  15      


Leu Lys Glu Gln Pro Ser Ser Pro Ala Pro Val Asn Gly Ser Lys Trp 
            20                  25                  30          


Thr Tyr Phe Gly Pro Asp Gly Glu Asn Ser Trp Ser Lys Lys Tyr Pro 
        35                  40                  45              


Ser Cys Gly Gly Leu Leu Gln Ser Pro Ile Asp Leu His Ser Asp Ile 
    50                  55                  60                  


Leu Gln Tyr Asp Ala Ser Leu Thr Pro Leu Glu Phe Gln Gly Tyr Asn 
65                  70                  75                  80  


Leu Ser Ala Asn Lys Gln Phe Leu Leu Thr Asn Asn Gly His Ser Val 
                85                  90                  95      


Lys Leu Asn Leu Pro Ser Asp Met His Ile Gln Gly Leu Gln Ser Arg 
            100                 105                 110         


Tyr Ser Ala Thr Gln Leu His Leu His Trp Gly Asn Pro Asn Asp Pro 
        115                 120                 125             


His Gly Ser Glu His Thr Val Ser Gly Gln His Phe Ala Ala Glu Leu 
    130                 135                 140                 


His Ile Val His Tyr Asn Ser Asp Leu Tyr Pro Asp Ala Ser Thr Ala 
145                 150                 155                 160 


Ser Asn Lys Ser Glu Gly Leu Ala Val Leu Ala Val Leu Ile Glu Met 
                165                 170                 175     


Gly Ser Phe Asn Pro Ser Tyr Asp Lys Ile Phe Ser His Leu Gln His 
            180                 185                 190         


Val Lys Tyr Lys Gly Gln Glu Ala Phe Val Pro Gly Phe Asn Ile Glu 
        195                 200                 205             


Glu Leu Leu Pro Glu Arg Thr Ala Glu Tyr Tyr Arg Tyr Arg Gly Ser 
    210                 215                 220                 


Leu Thr Thr Pro Pro Cys Asn Pro Thr Val Leu Trp Thr Val Phe Arg 
225                 230                 235                 240 


Asn Pro Val Gln Ile Ser Gln Glu Gln Leu Leu Ala Leu Glu Thr Ala 
                245                 250                 255     


Leu Tyr Cys Thr His Met Asp Asp Pro Ser Pro Arg Glu Met Ile Asn 
            260                 265                 270         


Asn Phe Arg Gln Val Gln Lys Phe Asp Glu Arg Leu Val Tyr Thr Ser 
        275                 280                 285             


Phe Ser Gln Val Gln Val Cys Thr Ala Ala Gly Leu Ser Leu Gly Ile 
    290                 295                 300                 


Ile Leu Ser Leu Ala Leu Ala Gly Ile Leu Gly Ile Cys Ile Val Val 
305                 310                 315                 320 


Val Val Ser Ile Trp Leu Phe Arg Arg Lys Ser Ile Lys Lys Gly Asp 
                325                 330                 335     


Asn Lys Gly Val Ile Tyr Lys Pro Ala Thr Lys Met Glu Thr Glu Ala 
            340                 345                 350         


His Ala 
        


<210>  3278
<211>  3959
<212>  DNA
<213>  Homosapiens

<400>  3278
ataaaagctg cccggggaag ccaggagagc gaagggcgga cgtactcgcc acggcaccca     60

ggctgcgcgc acgcggtccc ggtgtgcagc tggagagcga gcggccaccg ggagcccccg    120

gcacagcccg cgcccgcccc gcaggagccc gcgaagatgc cccggcgcag cctgcacgcg    180

gcggccgtgc tcctgctggt gatcttaaag gaacagcctt ccagcccggc cccagtgaac    240

ggttccaagt ggacttattt tggtcctgat ggggagaata gctggtccaa gaagtacccg    300

tcgtgtgggg gcctgctgca gtcccccata gacctgcaca gtgacatcct ccagtatgac    360

gccagcctca cgcccctcga gttccaaggc tacaatctgt ctgccaacaa gcagtttctc    420

ctgaccaaca atggccattc agtgaagctg aacctgccct cggacatgca catccagggc    480

ctccagtctc gctacagtgc cacgcagctg cacctgcact gggggaaccc gaatgacccg    540

cacggctctg agcacaccgt cagcggacag cacttcgccg ccgagctgca cattgtccat    600

tataactcag acctttatcc tgacgccagc actgccagca acaagtcaga aggcctcgct    660

gtcctggctg ttctcattga gatgggctcc ttcaatccgt cctatgacaa gatcttcagt    720

caccttcaac atgtaaagta caaaggccag gaagcattcg tcccgggatt caacattgaa    780

gagctgcttc cggagaggac cgctgaatat taccgctacc gggggtccct gaccacaccc    840

ccttgcaacc ccactgtgct ctggacagtt ttccgaaacc ccgtgcaaat ttcccaggag    900

cagctgctgg ctttggagac agccctgtac tgcacacaca tggacgaccc ttcccccaga    960

gaaatgatca acaacttccg gcaggtccag aagttcgatg agaggctggt atacacctcc   1020

ttctcccaag gcatcatcct ctcactggcc ctggctggca ttcttggcat ctgtattgtg   1080

gtggtggtgt ccatttggct tttcagaagg aagagtatca aaaaaggtga taacaaggga   1140

gtcatttaca agccagccac caagatggag actgaggccc acgcttgagg tccccggagc   1200

tcccgggcac atccaggaag gaccttgctt tggaccctac acacttcggc tctctggaca   1260

cttgcgacac ctcaaggtgt tctctgtagc tcaatctgca aacatgccag gcctcaggga   1320

tcctctgctg ggtgcctcct tgccttggga ccatggccac cccagagcca tccgatcgat   1380

ggatgggatg cactctcaga ccaagcagca ggaattcaaa gctgcttgct gtaactgtgt   1440

gagattgtga agtggtctga attctggaat cacaaaccaa gccatgctgg tgggccatta   1500

atggttggaa aacactttca tccggggctt tgccagagcg tgctttcaag tgtcctggaa   1560

attctgctgc ttctccaagc tttcagacaa gaatgtgcac tctctgctta ggttttgctt   1620

gggaaactca acttctttcc tctggagacg gggcatctcc ctctgatttc cttctgctat   1680

gacaaaacct ttaatctgca ccttacaact cggggacaaa tggggacagg aaggatcaag   1740

ttgtagagag aaaaagaaaa caagagatat acattgtgat atattaggga cactttcaca   1800

gtcctgtcct ctggatcaca gacactgcac agaccttagg gaatggcagg ttcaagttcc   1860

acttcttggt ggggatgaga agggagagag agctagaggg acaaagagaa tgagaagaca   1920

tggatgatct gggagagtct cactttggaa tcagaattgg aatcacattc tgtttatcaa   1980

gccataatgt aaggacagaa taatacaata ttaagtccaa atccaacctc ctgtcagtgg   2040

agcagttatg ttttatactc tacagatttt acaaataatg aggctgttcc ttgaaaatgt   2100

gttgttgctg tgtcctggag gagacatgag ttccgagatg acccaatctg cctttgaatc   2160

tggaggaaat aggcagaaac aaaatgactg tagaacttat tctctgtagg ccaaatttca   2220

tttcagccac ttctgcagga tccctactgc caacctggaa tggagacttt tatctacttc   2280

tctctctctg aagatgtcaa atcgtggttt agatcaaata tatttcaagc tataaaagca   2340

ggaggttatc tgtgcagggg gctggcatca tgtatttagg ggcaagtaat aatggaatgc   2400

tactaagata ctccatattc ttccccgaat cacacagaca gtttctgaca ggcgcaactc   2460

ctccattttc ctcccgcagg tgagaaccct gtggagatga gtcagtgcca tgactgagaa   2520

ggaaccgacc cctagttgag agcaccttgc agttccccga gaactttctg attcacagtc   2580

tcattttgac agcatgaaat gtcctcttga agcatagctt tttaaatatc tttttccttc   2640

tactcctccc tctgactcta agaattctct cttctggaat cgcttgaacc caggaggcgg   2700

aggttgcagt aagccaaggt catgccactg cactctagcc tgggtgacag agcgagactc   2760

catctcaaaa aaaaaaaaaa aaaaattatt ctgtaccatc acaacttttc acaacgatgg   2820

caagccttat gtcttgggag cctgttttgc taggcaaagt tacaagtgac ctaatgggag   2880

ctcaaatgtg tgtgtgtctc tctgtgtgtt tgtgtgtgtg tgtgcactca agacctctaa   2940

cagcctcgaa gcctggggtg gcatcccggc cttgccatta gcatgcctca tgcatcatca   3000

gatgacaagg acaaccctca tgacgaagca acatgaatta gggggcctct tggccttggt   3060

ccaaaattgt caatcagaaa tgaacataaa ggactccaga gcagtgggac tgtctgtcaa   3120

aagactctgt atatcttttg tggatgagtt ttgtgagaga acagagagac cattgtacct   3180

ggcacaaggg ctgttcatga aaagggagac ttactgggag gtgcaagaca gtggcatttc   3240

tcctctcctc ttgctgctca gcacagccct ggattgcagc cccgaggctg agaccagaca   3300

aagcccggga ggcagaaaga tgctccaaga accaacacta tcaatgtctt tgcaaatcct   3360

cacaggattc ctgtgggtcc agctttggaa ctgggaaacc tttcttcgga tccgcactca   3420

ttccactgat gccagctgcc cctgaaggat gccagtactg tggtgtgtga gtctcagcag   3480

ccgcccacac gctcctaact ctgctgcatg gcagatgcct aggtggaaat agcaaaaaca   3540

aggcccaggc tggggccagg gccagagggg aaggccctgg attctcactc atgtgagatc   3600

ttgaatctct ttctttgttc tgtttgttta gttagtatca tctggtaaaa tagttaaaaa   3660

acaacaaaaa actctgtatc tgtttctagc atgtgctgca ttgactctat taatcacatt   3720

tcaaattcac cctacattcc tctcctcttc actagcctct ctgaaggtgt cctggccagc   3780

cctggagaag cactggtgtc tgcagcaccc ctcagttcct gtgcctcagc ccacaggcca   3840

ctgtgataat ggtctgttta gcacttctgt atttattgta agaatgatta taatgaagat   3900

acacactgta actacaagaa attataaatg tttttcacat caaaaaaaaa aaaaaaaaa    3959


<210>  3279
<211>  343
<212>  PRT
<213>  Homosapiens

<400>  3279

Met Pro Arg Arg Ser Leu His Ala Ala Ala Val Leu Leu Leu Val Ile 
1               5                   10                  15      


Leu Lys Glu Gln Pro Ser Ser Pro Ala Pro Val Asn Gly Ser Lys Trp 
            20                  25                  30          


Thr Tyr Phe Gly Pro Asp Gly Glu Asn Ser Trp Ser Lys Lys Tyr Pro 
        35                  40                  45              


Ser Cys Gly Gly Leu Leu Gln Ser Pro Ile Asp Leu His Ser Asp Ile 
    50                  55                  60                  


Leu Gln Tyr Asp Ala Ser Leu Thr Pro Leu Glu Phe Gln Gly Tyr Asn 
65                  70                  75                  80  


Leu Ser Ala Asn Lys Gln Phe Leu Leu Thr Asn Asn Gly His Ser Val 
                85                  90                  95      


Lys Leu Asn Leu Pro Ser Asp Met His Ile Gln Gly Leu Gln Ser Arg 
            100                 105                 110         


Tyr Ser Ala Thr Gln Leu His Leu His Trp Gly Asn Pro Asn Asp Pro 
        115                 120                 125             


His Gly Ser Glu His Thr Val Ser Gly Gln His Phe Ala Ala Glu Leu 
    130                 135                 140                 


His Ile Val His Tyr Asn Ser Asp Leu Tyr Pro Asp Ala Ser Thr Ala 
145                 150                 155                 160 


Ser Asn Lys Ser Glu Gly Leu Ala Val Leu Ala Val Leu Ile Glu Met 
                165                 170                 175     


Gly Ser Phe Asn Pro Ser Tyr Asp Lys Ile Phe Ser His Leu Gln His 
            180                 185                 190         


Val Lys Tyr Lys Gly Gln Glu Ala Phe Val Pro Gly Phe Asn Ile Glu 
        195                 200                 205             


Glu Leu Leu Pro Glu Arg Thr Ala Glu Tyr Tyr Arg Tyr Arg Gly Ser 
    210                 215                 220                 


Leu Thr Thr Pro Pro Cys Asn Pro Thr Val Leu Trp Thr Val Phe Arg 
225                 230                 235                 240 


Asn Pro Val Gln Ile Ser Gln Glu Gln Leu Leu Ala Leu Glu Thr Ala 
                245                 250                 255     


Leu Tyr Cys Thr His Met Asp Asp Pro Ser Pro Arg Glu Met Ile Asn 
            260                 265                 270         


Asn Phe Arg Gln Val Gln Lys Phe Asp Glu Arg Leu Val Tyr Thr Ser 
        275                 280                 285             


Phe Ser Gln Gly Ile Ile Leu Ser Leu Ala Leu Ala Gly Ile Leu Gly 
    290                 295                 300                 


Ile Cys Ile Val Val Val Val Ser Ile Trp Leu Phe Arg Arg Lys Ser 
305                 310                 315                 320 


Ile Lys Lys Gly Asp Asn Lys Gly Val Ile Tyr Lys Pro Ala Thr Lys 
                325                 330                 335     


Met Glu Thr Glu Ala His Ala 
            340             


<210>  3280
<211>  2345
<212>  DNA
<213>  Homosapiens

<400>  3280
ctcgagacgc agccgccgtc ggccgagcgc ccggctagaa gcgacaccag acggagcctc     60

cggagttcct ccgcccccac ctcgccgggt cctggagccg cagtcctccc agctgccctc    120

ctcgtggcca tggagtgtcc acacctgagc tccagcgtct gcattgctcc ggactcagcc    180

aagttcccca acggctcccc gtcgtcctgg tgctgcagcg tgtgccggtc caacaaaagc    240

ccttgggtct gtttgacttg ttcaagtgtc cactgtggaa ggtatgtgaa tggccatgca    300

aaaaaacatt atgaagatgc acaagtacct ttaaccaacc ataagaaatc agaaaagcaa    360

gataaagttc agcacacagt atgtatggat tgcagtagct acagtacata ctgttatcgc    420

tgtgatgatt ttgtggttaa tgacaccaag ctgggactgg tacagaaagt cagagaacac    480

ttacagaact tggaaaactc agctttcaca gctgacaggc ataagaaaag aaaacttttg    540

gaaaactcaa cactaaacag caagttatta aaagtaaatg gaagcaccac tgccatttgt    600

gccacaggcc ttcggaattt ggggaacaca tgtttcatga atgccatcct tcagtcactc    660

agtaacattg agcagttttg ctgttatttc aaagaactgc ccgccgtgga gttaaggaat    720

gggaaaacag caggaaggcg gacataccac accaggagcc aaggggataa caatgtgtct    780

ttggtagaag agtttagaaa gacactctgt gctttatggc aaggcagcca gactgcattt    840

agcccagagt ccttatttta tgttgtttgg aagattatgc caaactttag gggctatcaa    900

cagcaggacg cccatgaatt catgcgctac cttttggacc acctacactt ggaacttcag    960

ggcggtttca acggtgtttc ccgctcagca attctgcagg agaattctac tctgtctgca   1020

agtaacaagt gttgcataaa tggagcatct actgttgtca cggctatatt cggaggcatt   1080

ctccaaaatg aggttaactg cctcatatgt gggacagaat ctagaaagtt tgatccattc   1140

ctagaccttt cattagatat tccaagtcag ttcagaagta agcgctctaa gaatcaagaa   1200

aatggaccag tttgttcgtt acgagattgt cttcgcagtt ttaccgactt agaagaactt   1260

gatgagacag agttatatat gtgccataaa tgcaaaaaga aacaaaagtc cacaaaaaag   1320

ttttggattc aaaaactacc caaggtgcta tgcttacatt tgaaaagatt tcattggaca   1380

gcatatttaa gaaataaagt tgatacatac gtagaatttc cactgagagg cctagacatg   1440

aaatgctact tactagagcc tgagaacagt ggcccggaga gctgcctgta tgacctcgcc   1500

gctgtggtgg tgcaccatgg ttccggggtt ggttctggac attacacagc atacgcaact   1560

cacgaaggcc gctggttcca cttcaatgac agtactgtaa cactgactga cgaggagact   1620

gtggtgaagg cgaaggccta catccttttc tacgtggaac accaggccaa agctggatcg   1680

gataaacttt aatacctcct ccaaatcatc attcaccaac cataccagag aaacatttcc   1740

agttttccac aaatacttga tacaagattt aatttcatta tgcacttttc aatttcctat   1800

tttggattta gttttgtcaa tggtagtgac ttactgaaca tgggcaccaa ctaattttgt   1860

tgttgttcta ccagaaaacc tcagcagatg ttttgatttg ctgctttagt tgtaataatt   1920

caatttttat aggtagttgt aagaacttag tcttatttga cttttttatt ttatgttaat   1980

gttttcagtt ctcactttga ggcacattta catcaatgct tttgttcctc tcacatgctg   2040

aaagcaagat gtgttcctta ttgtgaagag cgacacaact gcctgctgcc tttccacagc   2100

tataatggac atcaggttga ctctaaatca aggatcatgt gtgcacaata cttgtggccc   2160

acaaaatttc acaatgactg ctgaggaatc attctttttg cctgtaaaat ataacaaagg   2220

gcatcattaa gtagaccagg taattactgc ttgtctctca aggctgctgt ctttatcagc   2280

actaactaaa taaatttgtt ggttcagttg tacttgtcct gcaaatacaa aaaaaaaaaa   2340

aaaaa                                                               2345


<210>  3281
<211>  520
<212>  PRT
<213>  Homosapiens

<400>  3281

Met Glu Cys Pro His Leu Ser Ser Ser Val Cys Ile Ala Pro Asp Ser 
1               5                   10                  15      


Ala Lys Phe Pro Asn Gly Ser Pro Ser Ser Trp Cys Cys Ser Val Cys 
            20                  25                  30          


Arg Ser Asn Lys Ser Pro Trp Val Cys Leu Thr Cys Ser Ser Val His 
        35                  40                  45              


Cys Gly Arg Tyr Val Asn Gly His Ala Lys Lys His Tyr Glu Asp Ala 
    50                  55                  60                  


Gln Val Pro Leu Thr Asn His Lys Lys Ser Glu Lys Gln Asp Lys Val 
65                  70                  75                  80  


Gln His Thr Val Cys Met Asp Cys Ser Ser Tyr Ser Thr Tyr Cys Tyr 
                85                  90                  95      


Arg Cys Asp Asp Phe Val Val Asn Asp Thr Lys Leu Gly Leu Val Gln 
            100                 105                 110         


Lys Val Arg Glu His Leu Gln Asn Leu Glu Asn Ser Ala Phe Thr Ala 
        115                 120                 125             


Asp Arg His Lys Lys Arg Lys Leu Leu Glu Asn Ser Thr Leu Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Val Asn Gly Ser Thr Thr Ala Ile Cys Ala Thr Gly 
145                 150                 155                 160 


Leu Arg Asn Leu Gly Asn Thr Cys Phe Met Asn Ala Ile Leu Gln Ser 
                165                 170                 175     


Leu Ser Asn Ile Glu Gln Phe Cys Cys Tyr Phe Lys Glu Leu Pro Ala 
            180                 185                 190         


Val Glu Leu Arg Asn Gly Lys Thr Ala Gly Arg Arg Thr Tyr His Thr 
        195                 200                 205             


Arg Ser Gln Gly Asp Asn Asn Val Ser Leu Val Glu Glu Phe Arg Lys 
    210                 215                 220                 


Thr Leu Cys Ala Leu Trp Gln Gly Ser Gln Thr Ala Phe Ser Pro Glu 
225                 230                 235                 240 


Ser Leu Phe Tyr Val Val Trp Lys Ile Met Pro Asn Phe Arg Gly Tyr 
                245                 250                 255     


Gln Gln Gln Asp Ala His Glu Phe Met Arg Tyr Leu Leu Asp His Leu 
            260                 265                 270         


His Leu Glu Leu Gln Gly Gly Phe Asn Gly Val Ser Arg Ser Ala Ile 
        275                 280                 285             


Leu Gln Glu Asn Ser Thr Leu Ser Ala Ser Asn Lys Cys Cys Ile Asn 
    290                 295                 300                 


Gly Ala Ser Thr Val Val Thr Ala Ile Phe Gly Gly Ile Leu Gln Asn 
305                 310                 315                 320 


Glu Val Asn Cys Leu Ile Cys Gly Thr Glu Ser Arg Lys Phe Asp Pro 
                325                 330                 335     


Phe Leu Asp Leu Ser Leu Asp Ile Pro Ser Gln Phe Arg Ser Lys Arg 
            340                 345                 350         


Ser Lys Asn Gln Glu Asn Gly Pro Val Cys Ser Leu Arg Asp Cys Leu 
        355                 360                 365             


Arg Ser Phe Thr Asp Leu Glu Glu Leu Asp Glu Thr Glu Leu Tyr Met 
    370                 375                 380                 


Cys His Lys Cys Lys Lys Lys Gln Lys Ser Thr Lys Lys Phe Trp Ile 
385                 390                 395                 400 


Gln Lys Leu Pro Lys Val Leu Cys Leu His Leu Lys Arg Phe His Trp 
                405                 410                 415     


Thr Ala Tyr Leu Arg Asn Lys Val Asp Thr Tyr Val Glu Phe Pro Leu 
            420                 425                 430         


Arg Gly Leu Asp Met Lys Cys Tyr Leu Leu Glu Pro Glu Asn Ser Gly 
        435                 440                 445             


Pro Glu Ser Cys Leu Tyr Asp Leu Ala Ala Val Val Val His His Gly 
    450                 455                 460                 


Ser Gly Val Gly Ser Gly His Tyr Thr Ala Tyr Ala Thr His Glu Gly 
465                 470                 475                 480 


Arg Trp Phe His Phe Asn Asp Ser Thr Val Thr Leu Thr Asp Glu Glu 
                485                 490                 495     


Thr Val Val Lys Ala Lys Ala Tyr Ile Leu Phe Tyr Val Glu His Gln 
            500                 505                 510         


Ala Lys Ala Gly Ser Asp Lys Leu 
        515                 520 


<210>  3282
<211>  1526
<212>  DNA
<213>  Homosapiens

<400>  3282
ggccactgct caccatgcac ataacccagc tcaaccggga gtgcctgctg cacctcttct     60

ccttcctaga caaggacagc aggaagagcc ttgccaggac ctgctcccag ctccacgacg    120

tgtttgagga ccccgcactc tggtccctgc tgcacttccg ttccctcact gaactccaga    180

aggacaactt cctcctgggc ccggcactcc gcagcctctc catctgctgg cactccagcc    240

gcgtgcaggt gtgcagcatt gaggactggc tcaagagtgc cttccagaga agcatctgca    300

gccggcacga gagcctggtc aatgatttcc tcctccgggt gtgcgacagg ctttctgctg    360

tgcgctcccc acggaggcgg gaggcgcctg caccgtcctc ggggactccg atcgccgttg    420

gaccgaaatc acctcggtgg ggaggacctg accactcgga gttcgccgac ttgcgctcgg    480

gggtgacggg ggccagggct gccgcgcgca ggggtctggg gagcctccgg gcggagcgac    540

ccagcgagac cccgccggct cccggagtgt cctggggacc gccacctcca ggagccccgg    600

tggtgatctc ggtgaagcag gaggagggga agcaggggcg cacgggcaga aggagccacc    660

gagccgctcc tccttgcggt tttgcccgca cgcgcgtctg cccgcccacc tttcctgggg    720

cggatgcgtt cccgcagtga ccgcactcgc gattgtagaa aattcgctcc caattgttga    780

atgcttacat aaactgcata gttacccata ttttctactg ttctcataag ggaaaaagaa    840

atgatttgga agaaaaaaaa agcctcaaac taaacaaaaa caaaaccagc agccctggct    900

aagcttttga taatggaacc attataagct gacaagctag atttttcacc tgttggattt    960

gctggacatg agcacaagcc taggcttcca atttgaattt cagggctgta gtcactgatg   1020

tgtcacattt agtgaaggct ctcggccccc cggcagccgc ctggtcctgg gtcactgggg   1080

agaattctgg gtgggtggaa gaggcgagga gcactgtgat gggcgctgtt cacactccgg   1140

ctccacccag cgccagctgc gacaaagccc tttacccctc ccaggccagg tgtttcttct   1200

gtgtgaaaga ggagcttgat ccctactcac aggttcctta attcattgct caaagaggga   1260

aacagcaagg aaaaagacaa attctgttct catgaagctt accttctagt gggggaagag   1320

acaacaggta actggtatat aagagggtag aagggccagg tgcggtggct caatgcctgt   1380

aatcccagca ctttaggagg ccaagatggg cgattcacga ggtcaggaga tcgagaccat   1440

cctggctaac aaggtgaaac ccccgtctgt actaaaaaaa aaaaaaaaaa aaaaaaaaaa   1500

aaaaaaaaaa aaaaaaaaaa aaaaaa                                        1526


<210>  3283
<211>  241
<212>  PRT
<213>  Homosapiens

<400>  3283

Met His Ile Thr Gln Leu Asn Arg Glu Cys Leu Leu His Leu Phe Ser 
1               5                   10                  15      


Phe Leu Asp Lys Asp Ser Arg Lys Ser Leu Ala Arg Thr Cys Ser Gln 
            20                  25                  30          


Leu His Asp Val Phe Glu Asp Pro Ala Leu Trp Ser Leu Leu His Phe 
        35                  40                  45              


Arg Ser Leu Thr Glu Leu Gln Lys Asp Asn Phe Leu Leu Gly Pro Ala 
    50                  55                  60                  


Leu Arg Ser Leu Ser Ile Cys Trp His Ser Ser Arg Val Gln Val Cys 
65                  70                  75                  80  


Ser Ile Glu Asp Trp Leu Lys Ser Ala Phe Gln Arg Ser Ile Cys Ser 
                85                  90                  95      


Arg His Glu Ser Leu Val Asn Asp Phe Leu Leu Arg Val Cys Asp Arg 
            100                 105                 110         


Leu Ser Ala Val Arg Ser Pro Arg Arg Arg Glu Ala Pro Ala Pro Ser 
        115                 120                 125             


Ser Gly Thr Pro Ile Ala Val Gly Pro Lys Ser Pro Arg Trp Gly Gly 
    130                 135                 140                 


Pro Asp His Ser Glu Phe Ala Asp Leu Arg Ser Gly Val Thr Gly Ala 
145                 150                 155                 160 


Arg Ala Ala Ala Arg Arg Gly Leu Gly Ser Leu Arg Ala Glu Arg Pro 
                165                 170                 175     


Ser Glu Thr Pro Pro Ala Pro Gly Val Ser Trp Gly Pro Pro Pro Pro 
            180                 185                 190         


Gly Ala Pro Val Val Ile Ser Val Lys Gln Glu Glu Gly Lys Gln Gly 
        195                 200                 205             


Arg Thr Gly Arg Arg Ser His Arg Ala Ala Pro Pro Cys Gly Phe Ala 
    210                 215                 220                 


Arg Thr Arg Val Cys Pro Pro Thr Phe Pro Gly Ala Asp Ala Phe Pro 
225                 230                 235                 240 


Gln 
    


<210>  3284
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3284
cctctgcgga gccgggctcg ggtcgccgga gccgcgcccc accccgccag ctccagagcc     60

acgactaatg gctgaaggat aaatcaacat ggcaactatg attccaccag tgaagctgaa    120

atggcttgaa cacttgaaca gctcctggat tacagaggac agtgaatcta ttgctacaag    180

agagggagtt gctgttctgt attctaaact ggttagcaat aaggaagtag tacctttgcc    240

ccaacaagtt ttatgcctca aaggaccaca gttgccagac tttgaacgtg agtctctttc    300

aagtgatgag caggaccact atttggatgc ccttcttagc agccagctag cattggcaaa    360

gatggtatgt tcagattccc catttgccgg ggcacttaga aaacgactgc ttgtactcca    420

gcgtgtcttt tatgcacttt ctaataaata ccatgacaaa ggcaaggtga agcagcagca    480

gcattctccg gagagcagtt ctggttcagc agatgtccat tctgttagtg aacgcccccg    540

gtcaagcact gatgcactta tagaaatggg tgttcgaact ggtctaagtt tattatttgc    600

gcttctaaga caaagttgga tgatgcctgt gtcaggacct ggtctcagtc tttgcaacga    660

tgtcattcat actgcaattg aagttgtgag ctctttgcca ccattatcat tagcaaatga    720

aagcaagatt cctcctatgg gcttggactg cttatcgcaa gtaacaacat ttcttaaagg    780

agtcactatt cctaattctg gggcagacac tttaggtcgt agattagctt ctgagttgct    840

gcttggtttg gcagctcaac gaggctcatt gcgatatctt cttgaatgga tagaaatggc    900

tttgggggct tcggcagttg tacacaccat ggagaaaggc aaactactct caagccagga    960

aggaatgatc agctttgact gctttatgac catattaatg cagatgaggc gttctttggg   1020

ttcatctgct gatcggagtc agtggagaga accaaccaga acatcggatg gcttgtgctc   1080

cctttacgag gcagcattat gtctctttga agaggtttgc agaatggctt ctgattattc   1140

gagaacatgt gctagcccag atagcattca gactggtgat gctcccattg tctccgaaac   1200

ctgtgaggtt tatgtttggg ggagcaatag cagccatcag ttggtagaag gtacacagga   1260

gaaaatactg caacccaaac tggctcctag tttctctgat gcacagacca ttgaagctgg   1320

acagtactgc acttttgtca tttctacgga tggctctgtt agagcttgcg ggaaaggcag   1380

ctatgggaga ctgggccttg gagactccaa taatcagtca actttaaaaa agttaacatt   1440

cgagcctcac agatccatta aaaaggtttc atcttctaaa ggatctgatg gtcacacttt   1500

agcctttacg acagaaggag aagtcttcag ttggggagat ggtgattatg ggaaactggg   1560

gcatggaaat agttcaacac agaaatatcc caagcttatt cagggacctc tacaaggaaa   1620

ggtagttgtt tgtgtgtcag ctggatacag acatagtgct gctgtcacag aggatgggga   1680

attatacaca tggggtgaag gagactttgg aagattaggt catggtgaca gcaatagtcg   1740

taacattcca acattagtaa aagacatcag caatgtagga gaggtttctt gtggcagttc   1800

acatactatt gctctgtcta aagatgggag aactgtatgg tcttttggag gaggagacaa   1860

tggtaaactt ggtcatggtg ataccaacag agtgtataaa cctaaagtta ttgaagcttt   1920

acaaggaatg ttcattcgca aagtttgtgc tgggagccag tcttcacttg ctttgacatc   1980

aacagggcag gtctatgctt ggggctgtgg agcttgtcta ggttgtggtt cttcagaagc   2040

tactgctttg agacccaagc ttattgaaga actggctgcc acaagaatag ttgatgtttc   2100

tattggagac agtcattgtt tggctctttc tcatgataat gaagtttatg cctggggcaa   2160

taactcaatg gggcaatgtg gtcagggaaa ttccacaggt cctattacta aaccaaagaa   2220

agtgagtggc ttagatggca tagctattca gcagatttcg gctggaacat cacatagtct   2280

ggcatggact gctcttccta gggacagaca agttgttgca tggcaccgac cttattgtgt   2340

agatcttgaa gagagtacct tctcacacct gcgttctttt cttgagagat actgtgataa   2400

aataaacagt gagattcccc cactcccttt cccttcatca agagaacacc acagttttct   2460

caagctgtgc ctgaagctac tttcaaatca ccttgctctt gcacttgcgg gaggggtagc   2520

taccagcatt ctcgggaggc aggcaggtcc acttcgaaat ttgctcttca gactgatgga   2580

ctcaactgtc ccagatgaaa tccaagaggt ggtaattgaa actttatcag tgggagcaac   2640

catgctgtta cctccattac gagaacggat ggaattactt cattctcttt tacctcaagg   2700

acctgataga tgggaaagct tatctaaagg acagagaatg caactggata tcatcctgac   2760

aagtttgcaa gatcataccc acgtagcctc cctacttggc tatagttcac cctctgatgc   2820

tgctgaccta tcttctgtgt gtactggcta cggaaatctg tcagatcaac cttacggcac   2880

tcagagctgc catccagata cccacctggc tgaaattttg atgaagaccc tcttaagaaa   2940

tttaggattt tatacagatc aagcatttgg agagctagaa aagaatagtg ataaatttct   3000

acttggaaca tcatcatcag aaaacagtca gcctgctcat cttcatgaac tgctatgttc   3060

actacagaaa cagctgctgg cattttgcca tatcaataac attagtgaga actcaagcag   3120

tgtggcattg cttcataaac atcttcagct tttgttgcct catgccacag atatttattc   3180

acgttctgca aatttgctca aagaaagtcc ttggaatggc agtgttggag aaaaattaag   3240

agatgtgata tacgtctcag ctgctggcag tatgctctgc cagattgtta actccctgct   3300

gttactccct gtgtcagtgg ctcggccttt attgagttac ctcctcgact tgttgccacc   3360

tcttgattgc cttaatagac tcctgccagc tgctgatctt ttagaagacc aggagttaca   3420

gtggcctctt catggagggc cagaactaat tgatcctgct ggtctgccat tacctcagcc   3480

agctcagtcc tgggtatggc ttgtggatct agaaagaaca attgctctcc ttattgggcg   3540

gtgtcttggt ggcatgcttc agggctcccc tgtgtctcca gaggaacagg acactgcata   3600

ttggatgaaa acgccactgt tcagtgacgg tgtagaaatg gacactcctc aattggataa   3660

atgtatgagt tgcctgttag aagtagcact ttctggaaat gaagaacaga agccttttga   3720

ttataaattg cggcctgaaa ttgctgtcta tgtagacttg gcattgggtt gttctaaaga   3780

gcctgcccga agcctttgga tcagcatgca ggactatgct gttagtaaag attgggacag   3840

tgcaacttta agtaatgagt cactcttgga cactgtgtct agatttgttc ttgcagctct   3900

tctgaaacac acaaatttac ttagtcaagc atgtggagaa agccgatatc aacctggtaa   3960

acacttatca gaagtgtacc gttgtgtata caaagttcga agtcgtttac ttgcttgcaa   4020

gaaccttgaa cttattcaaa caaggtcatc atcacgggac agatggatat cagaaaacca   4080

ggactctgca gatgttgatc ctcaggagca ttcatttact cgaactattg atgaagaagc   4140

tgaaatggaa gaacaggctg agagagaccg ggaagagggg catccggagc cagaggatga   4200

agaggaggaa cgggaacatg aagtgatgac agctggcaaa atctttcagt gtttcctctc   4260

agcccgtgaa gtagctcgta gccgagaccg agatagaatg aacagtgggg cagggtctgg   4320

ggctcgagct gatgatccac ctcctcagtc tcagcaagag cgaagggtca gcacagacct   4380

tcctgagggt caggatgtgt acactgctgc atgcaactcc gtgatccatc ggtgtgccct   4440

gttaatatta ggagtaagtc ctgtgataga tgagcttcag aagcgaagag aagaaggaca   4500

gttgcagcaa ccttcaacaa gtgcctctga agggggtgga cttatgacca ggagtgaaag   4560

tcttactgca gagagccggc tagtccacac aagcccaaat tatagactga tcaaatcgag   4620

gagtgaatct gatttgtctc agcctgaatc agatgaagag ggttacgcac tgagtggcag   4680

acgaaatgtt gatttggatt tggcagcatc tcacagaaag agaggtccta tgcacagtca   4740

attggaatcc ctgagtgact cttgggctcg cctgaaacat agcagagact ggttatgcaa   4800

ctcctcctat tcctttgagt cagattttga tcttaccaag tctttgggag ttcacacttt   4860

gattgaaaat gttgtaagct ttgtgagtgg agatgtgggg aatgccccag gttttaaaga   4920

gccagaggaa agtatgtcta caagtcccca ggcctccatc attgcaatgg aacagcagca   4980

gttaagggca gaacttcgtt tagaggcact tcatcagatc ctcgttctat tgtctgggat   5040

ggaagaaaaa ggtagcatct cactggcagg aagcagattg agttcaggct tccagtcctc   5100

cacactactc acgtctgtga ggctgcagtt cctagcaggg tgttttggtt taggcactgt   5160

tggacacaca ggagccaagg gagagagtgg ccgattgcat cactatcagg atgggatcag   5220

agcagctaag agaaatattc agattgaaat ccaggtagct gtgcataaaa tttatcaaca   5280

gttgtctgct accctggaaa gagccctgca agcaaacaag catcacattg aagcccagca   5340

acgtctgctt ctggttacag tttttgccct aagtgttcat tatcaaccag tagatgtttc   5400

tttggcaatt tccactggtc tgctaaacgt attgtcacag ttgtgtggta cagacaccat   5460

gctaggacag cccctgcagt tgttgccaaa gacgggtgtt tcccagctta gcacagcttt   5520

gaaagtggcc agtacaaggt tgctccagat tctagccatc actactggga cctatgctga   5580

taaactgagt cccaaagtag ttcaatcctt gttggatcta ctctgtagtc agttgaagaa   5640

tttattgtcc caaactggtg tactacatat ggcctctttc ggagaagggg agcaagaaga   5700

cggtgaagaa gaagaaaaaa aagttgactc cagtggagaa actgagaaga aagatttcag   5760

agctgctctt aggaaacaac atgcagccga actccatcta ggggattttt tagtttttct   5820

tcgcagagtt gtatcttcaa aagcaattca atcaaaaatg gcttccccaa agtggaccga   5880

agtgcttcta aatatagcat ctcagaaatg ttcttcaggt atccctctgg ttggtaactt   5940

aagaacaagg ctccttgcac ttcatgtcct tgaagctgtg ctgccagctt gtgaatctgg   6000

tgtagaagat gatcaaatgg cccagattgt tgagcgctta ttttcccttc tctctgattg   6060

tatgtgggag acacccattg ctcaggccaa acatgctatt cagataaagg aaaaagaaca   6120

agaaataaaa ctacagaagc agggcgagtt ggaagaagaa gatgagaatc ttcctatcca   6180

agaagtatcc tttgacccgg agaaagctca gtgttgccta gtggagaatg gacagatttt   6240

aactcacggc agtggaggga aaggatatgg attggcatct acaggagtaa cttctgggtg   6300

ctatcagtgg aagttttata ttgtgaagga aaacagaggt aatgaaggca cgtgtgttgg   6360

agtttctcgc tggccagtac atgactttaa tcaccgcact acctcggata tgtggctcta   6420

tagggcctac agtggtaacc tctatcacaa tggagaacag actctcacat tgtccagctt   6480

tactcaagga gatttcatta cctgtgtgtt agacatggaa gccaggacca tttcttttgg   6540

gaaaaatgga gaggaaccca aattagcttt tgaagatgtg gatgcagcag agttgtaccc   6600

atgtgtgatg ttctatagta gcaatccagg ggaaaaggtg aaaatttgtg atatgcagat   6660

gcgtggcaca ccccgagact tacttccagg agaccctatt tgtagtccag tagcagcagt   6720

gctggctgag gccactattc agctcatccg tatccttcac cgaacagacc gttggactta   6780

ctgcattaac aaaaaaatga tggaaaggct tcacaaaatt aagatatgta ttaaagagtc   6840

aggtcagaag ctaaagaaaa gccgctcggt tcagagccga gaggaaaatg aaatgagaga   6900

ggagaaggag agcaaagagg aagagaaagg taaacatact aggcatggcc tcgctgacct   6960

ctcagagctg cagctgagga ctctttgcat agaggtgtgg cccgtgctgg ctgtgatagg   7020

aggagttgat gctggtctta gagttggagg tcggtgtgtt cacaagcaaa ctgggcgcca   7080

tgccacgctg ctgggagtgg tcaaagaggg cagcacgtct gccaaggtcc aatgggatga   7140

agcagaaatt actatcagct tcccaacttt ttggtcgcct agtgatactc cattgtataa   7200

tctggaaccc tgtgaaccat tgccgtttga tgtggcgcga ttccgaggcc tgacggcttc   7260

tgtgctgctg gacctaacat atctcactgg cgttcatgaa gacatgggca aacagagcac   7320

caaacgacat gaaaagaaac accgacatga atccgaggag aaaggggatg ttgagcagaa   7380

acctgagagt gaatccgctt tagatatgcg aacaggccta acatctgatg acgtcaaaag   7440

tcagagtacc acaagctcca aatcagaaaa tgaaatcgct tcattttctt tagatccaac   7500

actgccaagt gtggaatccc aacatcaaat aacagaaggg aaaagaaaaa atcatgaaca   7560

catgtccaaa aaccatgatg tagcccagtc agaaatcaga gcagtccagc tgtcctatct   7620

ttacctcggt gctatgaagt cacttagtgc ccttcttggc tgtagtaaat atgctgagct   7680

gttgctgata ccaaaagttc tggctgaaaa tggccacaac tcagactgtg caagttctcc   7740

agttgttcat gaagacgtgg agatgcgagc agccctgcag ttcttgatgc gacacatggt   7800

gaagcgagca gtcatgcggt cacccataaa gagagcattg ggattagctg atctggaacg   7860

agcgcaagcc atgatctata aattagtggt tcatgggctt ttggaagacc agtttggggg   7920

caaaattaag caagagattg atcaacaagc tgaagaaagt gaccctgccc agcaggcaca   7980

gacaccagtt actactagcc catcagcctc aagcacgacc tcctttatga gcagctctct   8040

ggaggacacc acaactgcca ccactccagt cactgacaca gaaacagtgc ctgcatccga   8100

gtccccggga gtgatgcctc ttagtcttct caggcaaatg ttctctagtt acccaactac   8160

cactgtactt cccacacgtc gggcacagac tc                                 8192


<210>  3285
<211>  4861
<212>  PRT
<213>  Homosapiens

<400>  3285

Met Ala Thr Met Ile Pro Pro Val Lys Leu Lys Trp Leu Glu His Leu 
1               5                   10                  15      


Asn Ser Ser Trp Ile Thr Glu Asp Ser Glu Ser Ile Ala Thr Arg Glu 
            20                  25                  30          


Gly Val Ala Val Leu Tyr Ser Lys Leu Val Ser Asn Lys Glu Val Val 
        35                  40                  45              


Pro Leu Pro Gln Gln Val Leu Cys Leu Lys Gly Pro Gln Leu Pro Asp 
    50                  55                  60                  


Phe Glu Arg Glu Ser Leu Ser Ser Asp Glu Gln Asp His Tyr Leu Asp 
65                  70                  75                  80  


Ala Leu Leu Ser Ser Gln Leu Ala Leu Ala Lys Met Val Cys Ser Asp 
                85                  90                  95      


Ser Pro Phe Ala Gly Ala Leu Arg Lys Arg Leu Leu Val Leu Gln Arg 
            100                 105                 110         


Val Phe Tyr Ala Leu Ser Asn Lys Tyr His Asp Lys Gly Lys Val Lys 
        115                 120                 125             


Gln Gln Gln His Ser Pro Glu Ser Ser Ser Gly Ser Ala Asp Val His 
    130                 135                 140                 


Ser Val Ser Glu Arg Pro Arg Ser Ser Thr Asp Ala Leu Ile Glu Met 
145                 150                 155                 160 


Gly Val Arg Thr Gly Leu Ser Leu Leu Phe Ala Leu Leu Arg Gln Ser 
                165                 170                 175     


Trp Met Met Pro Val Ser Gly Pro Gly Leu Ser Leu Cys Asn Asp Val 
            180                 185                 190         


Ile His Thr Ala Ile Glu Val Val Ser Ser Leu Pro Pro Leu Ser Leu 
        195                 200                 205             


Ala Asn Glu Ser Lys Ile Pro Pro Met Gly Leu Asp Cys Leu Ser Gln 
    210                 215                 220                 


Val Thr Thr Phe Leu Lys Gly Val Thr Ile Pro Asn Ser Gly Ala Asp 
225                 230                 235                 240 


Thr Leu Gly Arg Arg Leu Ala Ser Glu Leu Leu Leu Gly Leu Ala Ala 
                245                 250                 255     


Gln Arg Gly Ser Leu Arg Tyr Leu Leu Glu Trp Ile Glu Met Ala Leu 
            260                 265                 270         


Gly Ala Ser Ala Val Val His Thr Met Glu Lys Gly Lys Leu Leu Ser 
        275                 280                 285             


Ser Gln Glu Gly Met Ile Ser Phe Asp Cys Phe Met Thr Ile Leu Met 
    290                 295                 300                 


Gln Met Arg Arg Ser Leu Gly Ser Ser Ala Asp Arg Ser Gln Trp Arg 
305                 310                 315                 320 


Glu Pro Thr Arg Thr Ser Asp Gly Leu Cys Ser Leu Tyr Glu Ala Ala 
                325                 330                 335     


Leu Cys Leu Phe Glu Glu Val Cys Arg Met Ala Ser Asp Tyr Ser Arg 
            340                 345                 350         


Thr Cys Ala Ser Pro Asp Ser Ile Gln Thr Gly Asp Ala Pro Ile Val 
        355                 360                 365             


Ser Glu Thr Cys Glu Val Tyr Val Trp Gly Ser Asn Ser Ser His Gln 
    370                 375                 380                 


Leu Val Glu Gly Thr Gln Glu Lys Ile Leu Gln Pro Lys Leu Ala Pro 
385                 390                 395                 400 


Ser Phe Ser Asp Ala Gln Thr Ile Glu Ala Gly Gln Tyr Cys Thr Phe 
                405                 410                 415     


Val Ile Ser Thr Asp Gly Ser Val Arg Ala Cys Gly Lys Gly Ser Tyr 
            420                 425                 430         


Gly Arg Leu Gly Leu Gly Asp Ser Asn Asn Gln Ser Thr Leu Lys Lys 
        435                 440                 445             


Leu Thr Phe Glu Pro His Arg Ser Ile Lys Lys Val Ser Ser Ser Lys 
    450                 455                 460                 


Gly Ser Asp Gly His Thr Leu Ala Phe Thr Thr Glu Gly Glu Val Phe 
465                 470                 475                 480 


Ser Trp Gly Asp Gly Asp Tyr Gly Lys Leu Gly His Gly Asn Ser Ser 
                485                 490                 495     


Thr Gln Lys Tyr Pro Lys Leu Ile Gln Gly Pro Leu Gln Gly Lys Val 
            500                 505                 510         


Val Val Cys Val Ser Ala Gly Tyr Arg His Ser Ala Ala Val Thr Glu 
        515                 520                 525             


Asp Gly Glu Leu Tyr Thr Trp Gly Glu Gly Asp Phe Gly Arg Leu Gly 
    530                 535                 540                 


His Gly Asp Ser Asn Ser Arg Asn Ile Pro Thr Leu Val Lys Asp Ile 
545                 550                 555                 560 


Ser Asn Val Gly Glu Val Ser Cys Gly Ser Ser His Thr Ile Ala Leu 
                565                 570                 575     


Ser Lys Asp Gly Arg Thr Val Trp Ser Phe Gly Gly Gly Asp Asn Gly 
            580                 585                 590         


Lys Leu Gly His Gly Asp Thr Asn Arg Val Tyr Lys Pro Lys Val Ile 
        595                 600                 605             


Glu Ala Leu Gln Gly Met Phe Ile Arg Lys Val Cys Ala Gly Ser Gln 
    610                 615                 620                 


Ser Ser Leu Ala Leu Thr Ser Thr Gly Gln Val Tyr Ala Trp Gly Cys 
625                 630                 635                 640 


Gly Ala Cys Leu Gly Cys Gly Ser Ser Glu Ala Thr Ala Leu Arg Pro 
                645                 650                 655     


Lys Leu Ile Glu Glu Leu Ala Ala Thr Arg Ile Val Asp Val Ser Ile 
            660                 665                 670         


Gly Asp Ser His Cys Leu Ala Leu Ser His Asp Asn Glu Val Tyr Ala 
        675                 680                 685             


Trp Gly Asn Asn Ser Met Gly Gln Cys Gly Gln Gly Asn Ser Thr Gly 
    690                 695                 700                 


Pro Ile Thr Lys Pro Lys Lys Val Ser Gly Leu Asp Gly Ile Ala Ile 
705                 710                 715                 720 


Gln Gln Ile Ser Ala Gly Thr Ser His Ser Leu Ala Trp Thr Ala Leu 
                725                 730                 735     


Pro Arg Asp Arg Gln Val Val Ala Trp His Arg Pro Tyr Cys Val Asp 
            740                 745                 750         


Leu Glu Glu Ser Thr Phe Ser His Leu Arg Ser Phe Leu Glu Arg Tyr 
        755                 760                 765             


Cys Asp Lys Ile Asn Ser Glu Ile Pro Pro Leu Pro Phe Pro Ser Ser 
    770                 775                 780                 


Arg Glu His His Ser Phe Leu Lys Leu Cys Leu Lys Leu Leu Ser Asn 
785                 790                 795                 800 


His Leu Ala Leu Ala Leu Ala Gly Gly Val Ala Thr Ser Ile Leu Gly 
                805                 810                 815     


Arg Gln Ala Gly Pro Leu Arg Asn Leu Leu Phe Arg Leu Met Asp Ser 
            820                 825                 830         


Thr Val Pro Asp Glu Ile Gln Glu Val Val Ile Glu Thr Leu Ser Val 
        835                 840                 845             


Gly Ala Thr Met Leu Leu Pro Pro Leu Arg Glu Arg Met Glu Leu Leu 
    850                 855                 860                 


His Ser Leu Leu Pro Gln Gly Pro Asp Arg Trp Glu Ser Leu Ser Lys 
865                 870                 875                 880 


Gly Gln Arg Met Gln Leu Asp Ile Ile Leu Thr Ser Leu Gln Asp His 
                885                 890                 895     


Thr His Val Ala Ser Leu Leu Gly Tyr Ser Ser Pro Ser Asp Ala Ala 
            900                 905                 910         


Asp Leu Ser Ser Val Cys Thr Gly Tyr Gly Asn Leu Ser Asp Gln Pro 
        915                 920                 925             


Tyr Gly Thr Gln Ser Cys His Pro Asp Thr His Leu Ala Glu Ile Leu 
    930                 935                 940                 


Met Lys Thr Leu Leu Arg Asn Leu Gly Phe Tyr Thr Asp Gln Ala Phe 
945                 950                 955                 960 


Gly Glu Leu Glu Lys Asn Ser Asp Lys Phe Leu Leu Gly Thr Ser Ser 
                965                 970                 975     


Ser Glu Asn Ser Gln Pro Ala His Leu His Glu Leu Leu Cys Ser Leu 
            980                 985                 990         


Gln Lys Gln Leu Leu Ala Phe Cys  His Ile Asn Asn Ile  Ser Glu Asn 
        995                 1000                 1005             


Ser Ser  Ser Val Ala Leu Leu  His Lys His Leu Gln  Leu Leu Leu 
    1010                 1015                 1020             


Pro His  Ala Thr Asp Ile Tyr  Ser Arg Ser Ala Asn  Leu Leu Lys 
    1025                 1030                 1035             


Glu Ser  Pro Trp Asn Gly Ser  Val Gly Glu Lys Leu  Arg Asp Val 
    1040                 1045                 1050             


Ile Tyr  Val Ser Ala Ala Gly  Ser Met Leu Cys Gln  Ile Val Asn 
    1055                 1060                 1065             


Ser Leu  Leu Leu Leu Pro Val  Ser Val Ala Arg Pro  Leu Leu Ser 
    1070                 1075                 1080             


Tyr Leu  Leu Asp Leu Leu Pro  Pro Leu Asp Cys Leu  Asn Arg Leu 
    1085                 1090                 1095             


Leu Pro  Ala Ala Asp Leu Leu  Glu Asp Gln Glu Leu  Gln Trp Pro 
    1100                 1105                 1110             


Leu His  Gly Gly Pro Glu Leu  Ile Asp Pro Ala Gly  Leu Pro Leu 
    1115                 1120                 1125             


Pro Gln  Pro Ala Gln Ser Trp  Val Trp Leu Val Asp  Leu Glu Arg 
    1130                 1135                 1140             


Thr Ile  Ala Leu Leu Ile Gly  Arg Cys Leu Gly Gly  Met Leu Gln 
    1145                 1150                 1155             


Gly Ser  Pro Val Ser Pro Glu  Glu Gln Asp Thr Ala  Tyr Trp Met 
    1160                 1165                 1170             


Lys Thr  Pro Leu Phe Ser Asp  Gly Val Glu Met Asp  Thr Pro Gln 
    1175                 1180                 1185             


Leu Asp  Lys Cys Met Ser Cys  Leu Leu Glu Val Ala  Leu Ser Gly 
    1190                 1195                 1200             


Asn Glu  Glu Gln Lys Pro Phe  Asp Tyr Lys Leu Arg  Pro Glu Ile 
    1205                 1210                 1215             


Ala Val  Tyr Val Asp Leu Ala  Leu Gly Cys Ser Lys  Glu Pro Ala 
    1220                 1225                 1230             


Arg Ser  Leu Trp Ile Ser Met  Gln Asp Tyr Ala Val  Ser Lys Asp 
    1235                 1240                 1245             


Trp Asp  Ser Ala Thr Leu Ser  Asn Glu Ser Leu Leu  Asp Thr Val 
    1250                 1255                 1260             


Ser Arg  Phe Val Leu Ala Ala  Leu Leu Lys His Thr  Asn Leu Leu 
    1265                 1270                 1275             


Ser Gln  Ala Cys Gly Glu Ser  Arg Tyr Gln Pro Gly  Lys His Leu 
    1280                 1285                 1290             


Ser Glu  Val Tyr Arg Cys Val  Tyr Lys Val Arg Ser  Arg Leu Leu 
    1295                 1300                 1305             


Ala Cys  Lys Asn Leu Glu Leu  Ile Gln Thr Arg Ser  Ser Ser Arg 
    1310                 1315                 1320             


Asp Arg  Trp Ile Ser Glu Asn  Gln Asp Ser Ala Asp  Val Asp Pro 
    1325                 1330                 1335             


Gln Glu  His Ser Phe Thr Arg  Thr Ile Asp Glu Glu  Ala Glu Met 
    1340                 1345                 1350             


Glu Glu  Gln Ala Glu Arg Asp  Arg Glu Glu Gly His  Pro Glu Pro 
    1355                 1360                 1365             


Glu Asp  Glu Glu Glu Glu Arg  Glu His Glu Val Met  Thr Ala Gly 
    1370                 1375                 1380             


Lys Ile  Phe Gln Cys Phe Leu  Ser Ala Arg Glu Val  Ala Arg Ser 
    1385                 1390                 1395             


Arg Asp  Arg Asp Arg Met Asn  Ser Gly Ala Gly Ser  Gly Ala Arg 
    1400                 1405                 1410             


Ala Asp  Asp Pro Pro Pro Gln  Ser Gln Gln Glu Arg  Arg Val Ser 
    1415                 1420                 1425             


Thr Asp  Leu Pro Glu Gly Gln  Asp Val Tyr Thr Ala  Ala Cys Asn 
    1430                 1435                 1440             


Ser Val  Ile His Arg Cys Ala  Leu Leu Ile Leu Gly  Val Ser Pro 
    1445                 1450                 1455             


Val Ile  Asp Glu Leu Gln Lys  Arg Arg Glu Glu Gly  Gln Leu Gln 
    1460                 1465                 1470             


Gln Pro  Ser Thr Ser Ala Ser  Glu Gly Gly Gly Leu  Met Thr Arg 
    1475                 1480                 1485             


Ser Glu  Ser Leu Thr Ala Glu  Ser Arg Leu Val His  Thr Ser Pro 
    1490                 1495                 1500             


Asn Tyr  Arg Leu Ile Lys Ser  Arg Ser Glu Ser Asp  Leu Ser Gln 
    1505                 1510                 1515             


Pro Glu  Ser Asp Glu Glu Gly  Tyr Ala Leu Ser Gly  Arg Arg Asn 
    1520                 1525                 1530             


Val Asp  Leu Asp Leu Ala Ala  Ser His Arg Lys Arg  Gly Pro Met 
    1535                 1540                 1545             


His Ser  Gln Leu Glu Ser Leu  Ser Asp Ser Trp Ala  Arg Leu Lys 
    1550                 1555                 1560             


His Ser  Arg Asp Trp Leu Cys  Asn Ser Ser Tyr Ser  Phe Glu Ser 
    1565                 1570                 1575             


Asp Phe  Asp Leu Thr Lys Ser  Leu Gly Val His Thr  Leu Ile Glu 
    1580                 1585                 1590             


Asn Val  Val Ser Phe Val Ser  Gly Asp Val Gly Asn  Ala Pro Gly 
    1595                 1600                 1605             


Phe Lys  Glu Pro Glu Glu Ser  Met Ser Thr Ser Pro  Gln Ala Ser 
    1610                 1615                 1620             


Ile Ile  Ala Met Glu Gln Gln  Gln Leu Arg Ala Glu  Leu Arg Leu 
    1625                 1630                 1635             


Glu Ala  Leu His Gln Ile Leu  Val Leu Leu Ser Gly  Met Glu Glu 
    1640                 1645                 1650             


Lys Gly  Ser Ile Ser Leu Ala  Gly Ser Arg Leu Ser  Ser Gly Phe 
    1655                 1660                 1665             


Gln Ser  Ser Thr Leu Leu Thr  Ser Val Arg Leu Gln  Phe Leu Ala 
    1670                 1675                 1680             


Gly Cys  Phe Gly Leu Gly Thr  Val Gly His Thr Gly  Ala Lys Gly 
    1685                 1690                 1695             


Glu Ser  Gly Arg Leu His His  Tyr Gln Asp Gly Ile  Arg Ala Ala 
    1700                 1705                 1710             


Lys Arg  Asn Ile Gln Ile Glu  Ile Gln Val Ala Val  His Lys Ile 
    1715                 1720                 1725             


Tyr Gln  Gln Leu Ser Ala Thr  Leu Glu Arg Ala Leu  Gln Ala Asn 
    1730                 1735                 1740             


Lys His  His Ile Glu Ala Gln  Gln Arg Leu Leu Leu  Val Thr Val 
    1745                 1750                 1755             


Phe Ala  Leu Ser Val His Tyr  Gln Pro Val Asp Val  Ser Leu Ala 
    1760                 1765                 1770             


Ile Ser  Thr Gly Leu Leu Asn  Val Leu Ser Gln Leu  Cys Gly Thr 
    1775                 1780                 1785             


Asp Thr  Met Leu Gly Gln Pro  Leu Gln Leu Leu Pro  Lys Thr Gly 
    1790                 1795                 1800             


Val Ser  Gln Leu Ser Thr Ala  Leu Lys Val Ala Ser  Thr Arg Leu 
    1805                 1810                 1815             


Leu Gln  Ile Leu Ala Ile Thr  Thr Gly Thr Tyr Ala  Asp Lys Leu 
    1820                 1825                 1830             


Ser Pro  Lys Val Val Gln Ser  Leu Leu Asp Leu Leu  Cys Ser Gln 
    1835                 1840                 1845             


Leu Lys  Asn Leu Leu Ser Gln  Thr Gly Val Leu His  Met Ala Ser 
    1850                 1855                 1860             


Phe Gly  Glu Gly Glu Gln Glu  Asp Gly Glu Glu Glu  Glu Lys Lys 
    1865                 1870                 1875             


Val Asp  Ser Ser Gly Glu Thr  Glu Lys Lys Asp Phe  Arg Ala Ala 
    1880                 1885                 1890             


Leu Arg  Lys Gln His Ala Ala  Glu Leu His Leu Gly  Asp Phe Leu 
    1895                 1900                 1905             


Val Phe  Leu Arg Arg Val Val  Ser Ser Lys Ala Ile  Gln Ser Lys 
    1910                 1915                 1920             


Met Ala  Ser Pro Lys Trp Thr  Glu Val Leu Leu Asn  Ile Ala Ser 
    1925                 1930                 1935             


Gln Lys  Cys Ser Ser Gly Ile  Pro Leu Val Gly Asn  Leu Arg Thr 
    1940                 1945                 1950             


Arg Leu  Leu Ala Leu His Val  Leu Glu Ala Val Leu  Pro Ala Cys 
    1955                 1960                 1965             


Glu Ser  Gly Val Glu Asp Asp  Gln Met Ala Gln Ile  Val Glu Arg 
    1970                 1975                 1980             


Leu Phe  Ser Leu Leu Ser Asp  Cys Met Trp Glu Thr  Pro Ile Ala 
    1985                 1990                 1995             


Gln Ala  Lys His Ala Ile Gln  Ile Lys Glu Lys Glu  Gln Glu Ile 
    2000                 2005                 2010             


Lys Leu  Gln Lys Gln Gly Glu  Leu Glu Glu Glu Asp  Glu Asn Leu 
    2015                 2020                 2025             


Pro Ile  Gln Glu Val Ser Phe  Asp Pro Glu Lys Ala  Gln Cys Cys 
    2030                 2035                 2040             


Leu Val  Glu Asn Gly Gln Ile  Leu Thr His Gly Ser  Gly Gly Lys 
    2045                 2050                 2055             


Gly Tyr  Gly Leu Ala Ser Thr  Gly Val Thr Ser Gly  Cys Tyr Gln 
    2060                 2065                 2070             


Trp Lys  Phe Tyr Ile Val Lys  Glu Asn Arg Gly Asn  Glu Gly Thr 
    2075                 2080                 2085             


Cys Val  Gly Val Ser Arg Trp  Pro Val His Asp Phe  Asn His Arg 
    2090                 2095                 2100             


Thr Thr  Ser Asp Met Trp Leu  Tyr Arg Ala Tyr Ser  Gly Asn Leu 
    2105                 2110                 2115             


Tyr His  Asn Gly Glu Gln Thr  Leu Thr Leu Ser Ser  Phe Thr Gln 
    2120                 2125                 2130             


Gly Asp  Phe Ile Thr Cys Val  Leu Asp Met Glu Ala  Arg Thr Ile 
    2135                 2140                 2145             


Ser Phe  Gly Lys Asn Gly Glu  Glu Pro Lys Leu Ala  Phe Glu Asp 
    2150                 2155                 2160             


Val Asp  Ala Ala Glu Leu Tyr  Pro Cys Val Met Phe  Tyr Ser Ser 
    2165                 2170                 2175             


Asn Pro  Gly Glu Lys Val Lys  Ile Cys Asp Met Gln  Met Arg Gly 
    2180                 2185                 2190             


Thr Pro  Arg Asp Leu Leu Pro  Gly Asp Pro Ile Cys  Ser Pro Val 
    2195                 2200                 2205             


Ala Ala  Val Leu Ala Glu Ala  Thr Ile Gln Leu Ile  Arg Ile Leu 
    2210                 2215                 2220             


His Arg  Thr Asp Arg Trp Thr  Tyr Cys Ile Asn Lys  Lys Met Met 
    2225                 2230                 2235             


Glu Arg  Leu His Lys Ile Lys  Ile Cys Ile Lys Glu  Ser Gly Gln 
    2240                 2245                 2250             


Lys Leu  Lys Lys Ser Arg Ser  Val Gln Ser Arg Glu  Glu Asn Glu 
    2255                 2260                 2265             


Met Arg  Glu Glu Lys Glu Ser  Lys Glu Glu Glu Lys  Gly Lys His 
    2270                 2275                 2280             


Thr Arg  His Gly Leu Ala Asp  Leu Ser Glu Leu Gln  Leu Arg Thr 
    2285                 2290                 2295             


Leu Cys  Ile Glu Val Trp Pro  Val Leu Ala Val Ile  Gly Gly Val 
    2300                 2305                 2310             


Asp Ala  Gly Leu Arg Val Gly  Gly Arg Cys Val His  Lys Gln Thr 
    2315                 2320                 2325             


Gly Arg  His Ala Thr Leu Leu  Gly Val Val Lys Glu  Gly Ser Thr 
    2330                 2335                 2340             


Ser Ala  Lys Val Gln Trp Asp  Glu Ala Glu Ile Thr  Ile Ser Phe 
    2345                 2350                 2355             


Pro Thr  Phe Trp Ser Pro Ser  Asp Thr Pro Leu Tyr  Asn Leu Glu 
    2360                 2365                 2370             


Pro Cys  Glu Pro Leu Pro Phe  Asp Val Ala Arg Phe  Arg Gly Leu 
    2375                 2380                 2385             


Thr Ala  Ser Val Leu Leu Asp  Leu Thr Tyr Leu Thr  Gly Val His 
    2390                 2395                 2400             


Glu Asp  Met Gly Lys Gln Ser  Thr Lys Arg His Glu  Lys Lys His 
    2405                 2410                 2415             


Arg His  Glu Ser Glu Glu Lys  Gly Asp Val Glu Gln  Lys Pro Glu 
    2420                 2425                 2430             


Ser Glu  Ser Ala Leu Asp Met  Arg Thr Gly Leu Thr  Ser Asp Asp 
    2435                 2440                 2445             


Val Lys  Ser Gln Ser Thr Thr  Ser Ser Lys Ser Glu  Asn Glu Ile 
    2450                 2455                 2460             


Ala Ser  Phe Ser Leu Asp Pro  Thr Leu Pro Ser Val  Glu Ser Gln 
    2465                 2470                 2475             


His Gln  Ile Thr Glu Gly Lys  Arg Lys Asn His Glu  His Met Ser 
    2480                 2485                 2490             


Lys Asn  His Asp Val Ala Gln  Ser Glu Ile Arg Ala  Val Gln Leu 
    2495                 2500                 2505             


Ser Tyr  Leu Tyr Leu Gly Ala  Met Lys Ser Leu Ser  Ala Leu Leu 
    2510                 2515                 2520             


Gly Cys  Ser Lys Tyr Ala Glu  Leu Leu Leu Ile Pro  Lys Val Leu 
    2525                 2530                 2535             


Ala Glu  Asn Gly His Asn Ser  Asp Cys Ala Ser Ser  Pro Val Val 
    2540                 2545                 2550             


His Glu  Asp Val Glu Met Arg  Ala Ala Leu Gln Phe  Leu Met Arg 
    2555                 2560                 2565             


His Met  Val Lys Arg Ala Val  Met Arg Ser Pro Ile  Lys Arg Ala 
    2570                 2575                 2580             


Leu Gly  Leu Ala Asp Leu Glu  Arg Ala Gln Ala Met  Ile Tyr Lys 
    2585                 2590                 2595             


Leu Val  Val His Gly Leu Leu  Glu Asp Gln Phe Gly  Gly Lys Ile 
    2600                 2605                 2610             


Lys Gln  Glu Ile Asp Gln Gln  Ala Glu Glu Ser Asp  Pro Ala Gln 
    2615                 2620                 2625             


Gln Ala  Gln Thr Pro Val Thr  Thr Ser Pro Ser Ala  Ser Ser Thr 
    2630                 2635                 2640             


Thr Ser  Phe Met Ser Ser Ser  Leu Glu Asp Thr Thr  Thr Ala Thr 
    2645                 2650                 2655             


Thr Pro  Val Thr Asp Thr Glu  Thr Val Pro Ala Ser  Glu Ser Pro 
    2660                 2665                 2670             


Gly Val  Met Pro Leu Ser Leu  Leu Arg Gln Met Phe  Ser Ser Tyr 
    2675                 2680                 2685             


Pro Thr  Thr Thr Val Leu Pro  Thr Arg Arg Ala Gln  Thr Pro Pro 
    2690                 2695                 2700             


Ile Ser  Ser Leu Pro Thr Ser  Pro Ser Asp Glu Val  Gly Arg Arg 
    2705                 2710                 2715             


Gln Ser  Leu Thr Ser Pro Asp  Ser Gln Ser Ala Arg  Pro Ala Asn 
    2720                 2725                 2730             


Arg Thr  Ala Leu Ser Asp Pro  Ser Ser Arg Leu Ser  Thr Ser Pro 
    2735                 2740                 2745             


Pro Pro  Pro Ala Ile Ala Val  Pro Leu Leu Glu Met  Gly Phe Ser 
    2750                 2755                 2760             


Leu Arg  Gln Ile Ala Lys Ala  Met Glu Ala Thr Gly  Ala Arg Gly 
    2765                 2770                 2775             


Glu Ala  Asp Ala Gln Asn Ile  Thr Val Leu Ala Met  Trp Met Ile 
    2780                 2785                 2790             


Glu His  Pro Gly His Glu Asp  Glu Glu Glu Pro Gln  Ser Gly Ser 
    2795                 2800                 2805             


Thr Ala  Asp Ser Arg Pro Gly  Ala Ala Val Leu Gly  Ser Gly Gly 
    2810                 2815                 2820             


Lys Ser  Asn Asp Pro Cys Tyr  Leu Gln Ser Pro Gly  Asp Ile Pro 
    2825                 2830                 2835             


Ser Ala  Asp Ala Ala Glu Met  Glu Glu Gly Phe Ser  Glu Ser Pro 
    2840                 2845                 2850             


Asp Asn  Leu Asp His Thr Glu  Asn Ala Ala Ser Gly  Ser Gly Pro 
    2855                 2860                 2865             


Ser Ala  Arg Gly Arg Ser Ala  Val Thr Arg Arg His  Lys Phe Asp 
    2870                 2875                 2880             


Leu Ala  Ala Arg Thr Leu Leu  Ala Arg Ala Ala Gly  Leu Tyr Arg 
    2885                 2890                 2895             


Ser Val  Gln Ala His Arg Asn  Gln Ser Arg Arg Glu  Gly Ile Ser 
    2900                 2905                 2910             


Leu Gln  Gln Asp Pro Gly Ala  Leu Tyr Asp Phe Asn  Leu Asp Glu 
    2915                 2920                 2925             


Glu Leu  Glu Ile Asp Leu Asp  Asp Glu Ala Met Glu  Ala Met Phe 
    2930                 2935                 2940             


Gly Gln  Asp Leu Thr Ser Asp  Asn Asp Ile Leu Gly  Met Trp Ile 
    2945                 2950                 2955             


Pro Glu  Val Leu Asp Trp Pro  Thr Trp His Val Cys  Glu Ser Glu 
    2960                 2965                 2970             


Asp Arg  Glu Glu Val Val Val  Cys Glu Leu Cys Glu  Cys Ser Val 
    2975                 2980                 2985             


Val Ser  Phe Asn Gln His Met  Lys Arg Asn His Pro  Gly Cys Gly 
    2990                 2995                 3000             


Arg Ser  Ala Asn Arg Gln Gly  Tyr Arg Ser Asn Gly  Ser Tyr Val 
    3005                 3010                 3015             


Asp Gly  Trp Phe Gly Gly Glu  Cys Gly Ser Gly Asn  Pro Tyr Tyr 
    3020                 3025                 3030             


Leu Leu  Cys Gly Thr Cys Arg  Glu Lys Tyr Leu Ala  Met Lys Thr 
    3035                 3040                 3045             


Lys Ser  Lys Ser Thr Ser Ser  Glu Arg Tyr Lys Gly  Gln Ala Pro 
    3050                 3055                 3060             


Asp Leu  Ile Gly Lys Gln Asp  Ser Val Tyr Glu Glu  Asp Trp Asp 
    3065                 3070                 3075             


Met Leu  Asp Val Asp Glu Asp  Glu Lys Leu Thr Gly  Glu Glu Glu 
    3080                 3085                 3090             


Phe Glu  Leu Leu Ala Gly Pro  Leu Gly Leu Asn Asp  Arg Arg Ile 
    3095                 3100                 3105             


Val Pro  Glu Pro Val Gln Phe  Pro Asp Ser Asp Pro  Leu Gly Ala 
    3110                 3115                 3120             


Ser Val  Ala Met Val Thr Ala  Thr Asn Ser Met Glu  Glu Thr Leu 
    3125                 3130                 3135             


Met Gln  Ile Gly Cys His Gly  Ser Val Glu Lys Ser  Ser Ser Gly 
    3140                 3145                 3150             


Arg Ile  Thr Leu Gly Glu Gln  Ala Ala Ala Leu Ala  Asn Pro His 
    3155                 3160                 3165             


Asp Arg  Val Val Ala Leu Arg  Arg Val Thr Ala Ala  Ala Gln Val 
    3170                 3175                 3180             


Leu Leu  Ala Arg Thr Met Val  Met Arg Ala Leu Ser  Leu Leu Ser 
    3185                 3190                 3195             


Val Ser  Gly Ser Ser Cys Ser  Leu Ala Ala Gly Leu  Glu Ser Leu 
    3200                 3205                 3210             


Gly Leu  Thr Asp Ile Arg Thr  Leu Val Arg Leu Met  Cys Leu Ala 
    3215                 3220                 3225             


Ala Ala  Gly Arg Ala Gly Leu  Ser Thr Ser Pro Ser  Ala Met Ala 
    3230                 3235                 3240             


Ser Thr  Ser Glu Arg Ser Arg  Gly Gly His Ser Lys  Ala Asn Lys 
    3245                 3250                 3255             


Pro Ile  Ser Cys Leu Ala Tyr  Leu Ser Thr Ala Val  Gly Cys Leu 
    3260                 3265                 3270             


Ala Ser  Asn Ala Pro Ser Ala  Ala Lys Leu Leu Val  Gln Leu Cys 
    3275                 3280                 3285             


Thr Gln  Asn Leu Ile Ser Ala  Ala Thr Gly Val Asn  Leu Thr Thr 
    3290                 3295                 3300             


Val Asp  Asp Ser Ile Gln Arg  Lys Phe Leu Pro Ser  Phe Leu Arg 
    3305                 3310                 3315             


Gly Ile  Ala Glu Glu Asn Lys  Leu Val Thr Ser Pro  Asn Phe Val 
    3320                 3325                 3330             


Val Thr  Gln Ala Leu Val Ala  Leu Leu Ala Asp Lys  Gly Ala Lys 
    3335                 3340                 3345             


Leu Arg  Pro Asn Tyr Asp Lys  Ser Glu Val Glu Lys  Lys Gly Pro 
    3350                 3355                 3360             


Leu Glu  Leu Ala Asn Ala Leu  Ala Ala Cys Cys Leu  Ser Ser Arg 
    3365                 3370                 3375             


Leu Ser  Ser Gln His Arg Gln  Trp Ala Ala Gln Gln  Leu Val Arg 
    3380                 3385                 3390             


Thr Leu  Ala Ala His Asp Arg  Asp Asn Gln Thr Thr  Leu Gln Thr 
    3395                 3400                 3405             


Leu Ala  Asp Met Gly Gly Asp  Leu Arg Lys Cys Ser  Phe Ile Lys 
    3410                 3415                 3420             


Leu Glu  Ala His Gln Asn Arg  Val Met Thr Cys Val  Trp Cys Asn 
    3425                 3430                 3435             


Lys Lys  Gly Leu Leu Ala Thr  Ser Gly Asn Asp Gly  Thr Ile Arg 
    3440                 3445                 3450             


Val Trp  Asn Val Thr Lys Lys  Gln Tyr Ser Leu Gln  Gln Thr Cys 
    3455                 3460                 3465             


Val Phe  Asn Arg Leu Glu Gly  Asp Ala Glu Glu Ser  Leu Gly Ser 
    3470                 3475                 3480             


Pro Ser  Asp Pro Ser Phe Ser  Pro Val Ser Trp Ser  Ile Ser Gly 
    3485                 3490                 3495             


Lys Tyr  Leu Ala Gly Ala Leu  Glu Lys Met Val Asn  Ile Trp Gln 
    3500                 3505                 3510             


Val Asn  Gly Gly Lys Gly Leu  Val Asp Ile Gln Pro  His Trp Val 
    3515                 3520                 3525             


Ser Ala  Leu Ala Trp Pro Glu  Glu Gly Pro Ala Thr  Ala Trp Ser 
    3530                 3535                 3540             


Gly Glu  Ser Pro Glu Leu Leu  Leu Val Gly Arg Met  Asp Gly Ser 
    3545                 3550                 3555             


Leu Gly  Leu Ile Glu Val Val  Asp Val Ser Thr Met  His Arg Arg 
    3560                 3565                 3570             


Glu Leu  Glu His Cys Tyr Arg  Lys Asp Val Ser Val  Thr Cys Ile 
    3575                 3580                 3585             


Ala Trp  Phe Ser Glu Asp Arg  Pro Phe Ala Val Gly  Tyr Phe Asp 
    3590                 3595                 3600             


Gly Lys  Leu Leu Leu Gly Thr  Lys Glu Pro Leu Glu  Lys Gly Gly 
    3605                 3610                 3615             


Ile Val  Leu Ile Asp Ala His  Lys Asp Thr Leu Ile  Ser Met Lys 
    3620                 3625                 3630             


Trp Asp  Pro Thr Gly His Ile  Leu Met Thr Cys Ala  Lys Glu Asp 
    3635                 3640                 3645             


Ser Val  Lys Leu Trp Gly Ser  Ile Ser Gly Cys Trp  Cys Cys Leu 
    3650                 3655                 3660             


His Ser  Leu Cys His Pro Ser  Ile Val Asn Gly Ile  Ala Trp Cys 
    3665                 3670                 3675             


Arg Leu  Pro Gly Lys Gly Ser  Lys Leu Gln Leu Leu  Met Ala Thr 
    3680                 3685                 3690             


Gly Cys  Gln Ser Gly Leu Val  Cys Val Trp Arg Ile  Pro Gln Asp 
    3695                 3700                 3705             


Thr Thr  Gln Thr Asn Val Thr  Ser Ala Glu Gly Trp  Trp Glu Gln 
    3710                 3715                 3720             


Glu Ser  Asn Cys Gln Asp Gly  Tyr Arg Lys Ser Ser  Gly Ala Lys 
    3725                 3730                 3735             


Cys Val  Tyr Gln Leu Arg Gly  His Ile Thr Pro Val  Arg Thr Val 
    3740                 3745                 3750             


Ala Phe  Ser Ser Asp Gly Leu  Ala Leu Val Ser Gly  Gly Leu Gly 
    3755                 3760                 3765             


Gly Leu  Met Asn Ile Trp Ser  Leu Arg Asp Gly Ser  Val Leu Gln 
    3770                 3775                 3780             


Thr Val  Val Ile Gly Ser Gly  Ala Ile Gln Thr Thr  Val Trp Ile 
    3785                 3790                 3795             


Pro Glu  Val Gly Val Ala Ala  Cys Ser Asn Arg Ser  Lys Asp Val 
    3800                 3805                 3810             


Leu Val  Val Asn Cys Thr Ala  Glu Trp Ala Ala Ala  Asn His Val 
    3815                 3820                 3825             


Leu Ala  Thr Cys Arg Thr Ala  Leu Lys Gln Gln Gly  Val Leu Gly 
    3830                 3835                 3840             


Leu Asn  Met Ala Pro Cys Met  Arg Ala Phe Leu Glu  Arg Leu Pro 
    3845                 3850                 3855             


Met Met  Leu Gln Glu Gln Tyr  Ala Tyr Glu Lys Pro  His Val Val 
    3860                 3865                 3870             


Cys Gly  Asp Gln Leu Val His  Ser Pro Tyr Met Gln  Cys Leu Ala 
    3875                 3880                 3885             


Ser Leu  Ala Val Gly Leu His  Leu Asp Gln Leu Leu  Cys Asn Pro 
    3890                 3895                 3900             


Pro Val  Pro Pro His His Gln  Asn Cys Leu Pro Asp  Pro Ala Ser 
    3905                 3910                 3915             


Trp Asn  Pro Asn Glu Trp Ala  Trp Leu Glu Cys Phe  Ser Thr Thr 
    3920                 3925                 3930             


Ile Lys  Ala Ala Glu Ala Leu  Thr Asn Gly Ala Gln  Phe Pro Glu 
    3935                 3940                 3945             


Ser Phe  Thr Val Pro Asp Leu  Glu Pro Val Pro Glu  Asp Glu Leu 
    3950                 3955                 3960             


Val Phe  Leu Met Asp Asn Ser  Lys Trp Ile Asn Gly  Met Asp Glu 
    3965                 3970                 3975             


Gln Ile  Met Ser Trp Ala Thr  Ser Arg Pro Glu Asp  Trp His Leu 
    3980                 3985                 3990             


Gly Gly  Lys Cys Asp Val Tyr  Leu Trp Gly Ala Gly  Arg His Gly 
    3995                 4000                 4005             


Gln Leu  Ala Glu Ala Gly Arg  Asn Val Met Val Pro  Ala Ala Ala 
    4010                 4015                 4020             


Pro Ser  Phe Ser Gln Ala Gln  Gln Val Ile Cys Gly  Gln Asn Cys 
    4025                 4030                 4035             


Thr Phe  Val Ile Gln Ala Asn  Gly Thr Val Leu Ala  Cys Gly Glu 
    4040                 4045                 4050             


Gly Ser  Tyr Gly Arg Leu Gly  Gln Gly Asn Ser Asp  Asp Leu His 
    4055                 4060                 4065             


Val Leu  Thr Val Ile Ser Ala  Leu Gln Gly Phe Val  Val Thr Gln 
    4070                 4075                 4080             


Leu Val  Thr Ser Cys Gly Ser  Asp Gly His Ser Met  Ala Leu Thr 
    4085                 4090                 4095             


Glu Ser  Gly Glu Val Phe Ser  Trp Gly Asp Gly Asp  Tyr Gly Lys 
    4100                 4105                 4110             


Leu Gly  His Gly Asn Ser Asp  Arg Gln Arg Arg Pro  Arg Gln Ile 
    4115                 4120                 4125             


Glu Ala  Leu Gln Gly Glu Glu  Val Val Gln Met Ser  Cys Gly Phe 
    4130                 4135                 4140             


Lys His  Ser Ala Val Val Thr  Ser Asp Gly Lys Leu  Phe Thr Phe 
    4145                 4150                 4155             


Gly Asn  Gly Asp Tyr Gly Arg  Leu Gly Leu Gly Asn  Thr Ser Asn 
    4160                 4165                 4170             


Lys Lys  Leu Pro Glu Arg Val  Thr Ala Leu Glu Gly  Tyr Gln Ile 
    4175                 4180                 4185             


Gly Gln  Val Ala Cys Gly Leu  Asn His Thr Leu Ala  Val Ser Ala 
    4190                 4195                 4200             


Asp Gly  Ser Met Val Trp Ala  Phe Gly Asp Gly Asp  Tyr Gly Lys 
    4205                 4210                 4215             


Leu Gly  Leu Gly Asn Ser Thr  Ala Lys Ser Ser Pro  Gln Lys Ile 
    4220                 4225                 4230             


Asp Val  Leu Cys Gly Ile Gly  Ile Lys Lys Val Ala  Cys Gly Thr 
    4235                 4240                 4245             


Gln Phe  Ser Val Ala Leu Thr  Lys Asp Gly His Val  Tyr Thr Phe 
    4250                 4255                 4260             


Gly Gln  Asp Arg Leu Ile Gly  Leu Pro Glu Gly Arg  Ala Arg Asn 
    4265                 4270                 4275             


His Asn  Arg Pro Gln Gln Ile  Pro Val Leu Ala Gly  Val Ile Ile 
    4280                 4285                 4290             


Glu Asp  Val Ala Val Gly Ala  Glu His Thr Leu Ala  Leu Ala Ser 
    4295                 4300                 4305             


Asn Gly  Asp Val Tyr Ala Trp  Gly Ser Asn Ser Glu  Gly Gln Leu 
    4310                 4315                 4320             


Gly Leu  Gly His Thr Asn His  Val Arg Glu Pro Thr  Leu Val Thr 
    4325                 4330                 4335             


Gly Leu  Gln Gly Lys Asn Val  Arg Gln Ile Ser Ala  Gly Arg Cys 
    4340                 4345                 4350             


His Ser  Ala Ala Trp Thr Ala  Pro Pro Val Pro Pro  Arg Ala Pro 
    4355                 4360                 4365             


Gly Val  Ser Val Pro Leu Gln  Leu Gly Leu Pro Asp  Thr Val Pro 
    4370                 4375                 4380             


Pro Gln  Tyr Gly Ala Leu Arg  Glu Val Ser Ile His  Thr Val Arg 
    4385                 4390                 4395             


Ala Arg  Leu Arg Leu Leu Tyr  His Phe Ser Asp Leu  Met Tyr Ser 
    4400                 4405                 4410             


Ser Trp  Arg Leu Leu Asn Leu  Ser Pro Asn Asn Gln  Asn Ser Thr 
    4415                 4420                 4425             


Ser His  Tyr Asn Ala Gly Thr  Trp Gly Ile Val Gln  Gly Gln Leu 
    4430                 4435                 4440             


Arg Pro  Leu Leu Ala Pro Arg  Val Tyr Thr Leu Pro  Met Val Arg 
    4445                 4450                 4455             


Ser Ile  Gly Lys Thr Met Val  Gln Gly Lys Asn Tyr  Gly Pro Gln 
    4460                 4465                 4470             


Ile Thr  Val Lys Arg Ile Ser  Thr Arg Gly Arg Lys  Cys Lys Pro 
    4475                 4480                 4485             


Ile Phe  Val Gln Ile Ala Arg  Gln Val Val Lys Leu  Asn Ala Ser 
    4490                 4495                 4500             


Asp Leu  Arg Leu Pro Ser Arg  Ala Trp Lys Val Lys  Leu Val Gly 
    4505                 4510                 4515             


Glu Gly  Ala Asp Asp Ala Gly  Gly Val Phe Asp Asp  Thr Ile Thr 
    4520                 4525                 4530             


Glu Met  Cys Gln Glu Leu Glu  Thr Gly Ile Val Asp  Leu Leu Ile 
    4535                 4540                 4545             


Pro Ser  Pro Asn Ala Thr Ala  Glu Val Gly Tyr Asn  Arg Asp Arg 
    4550                 4555                 4560             


Phe Leu  Phe Asn Pro Ser Ala  Cys Leu Asp Glu His  Leu Met Gln 
    4565                 4570                 4575             


Phe Lys  Phe Leu Gly Ile Leu  Met Gly Val Ala Ile  Arg Thr Lys 
    4580                 4585                 4590             


Lys Pro  Leu Asp Leu His Leu  Ala Pro Leu Val Trp  Lys Gln Leu 
    4595                 4600                 4605             


Cys Cys  Val Pro Leu Thr Leu  Glu Asp Leu Glu Glu  Val Asp Leu 
    4610                 4615                 4620             


Leu Tyr  Val Gln Thr Leu Asn  Ser Ile Leu His Ile  Glu Asp Ser 
    4625                 4630                 4635             


Gly Ile  Thr Glu Glu Ser Phe  His Glu Met Ile Pro  Leu Asp Ser 
    4640                 4645                 4650             


Phe Val  Gly Gln Ser Ala Asp  Gly Lys Met Val Pro  Ile Ile Pro 
    4655                 4660                 4665             


Gly Gly  Asn Ser Ile Pro Leu  Thr Phe Ser Asn Arg  Lys Glu Tyr 
    4670                 4675                 4680             


Val Glu  Arg Ala Ile Glu Tyr  Arg Leu His Glu Met  Asp Arg Gln 
    4685                 4690                 4695             


Val Ala  Ala Val Arg Glu Gly  Met Ser Trp Ile Val  Pro Val Pro 
    4700                 4705                 4710             


Leu Leu  Ser Leu Leu Thr Ala  Lys Gln Leu Glu Gln  Met Val Cys 
    4715                 4720                 4725             


Gly Met  Pro Glu Ile Ser Val  Glu Val Leu Lys Lys  Val Val Arg 
    4730                 4735                 4740             


Tyr Arg  Glu Val Asp Glu Gln  His Gln Leu Val Gln  Trp Phe Trp 
    4745                 4750                 4755             


His Thr  Leu Glu Glu Phe Ser  Asn Glu Glu Arg Val  Leu Phe Met 
    4760                 4765                 4770             


Arg Phe  Val Ser Gly Arg Ser  Arg Leu Pro Ala Asn  Thr Ala Asp 
    4775                 4780                 4785             


Ile Ser  Gln Arg Phe Gln Ile  Met Lys Val Asp Arg  Pro Tyr Asp 
    4790                 4795                 4800             


Ser Leu  Pro Thr Ser Gln Thr  Cys Phe Phe Gln Leu  Arg Leu Pro 
    4805                 4810                 4815             


Pro Tyr  Ser Ser Gln Leu Val  Met Ala Glu Arg Leu  Arg Tyr Ala 
    4820                 4825                 4830             


Ile Asn  Asn Cys Arg Ser Ile  Asp Met Asp Asn Tyr  Met Leu Ser 
    4835                 4840                 4845             


Arg Asn  Val Asp Asn Ala Glu  Gly Ser Asp Thr Asp  Tyr 
    4850                 4855                 4860     


<210>  3286
<211>  2351
<212>  DNA
<213>  Homosapiens

<400>  3286
tgcgggcagg attcacgccg ctgtgacccg gaggtcctca gggggcgaag ccccggccta     60

ggcctcgcgg agatgcccag ctgcggtgct tgtacttgcg gcgcggcggc cgtccggctc    120

atcacctcct cactcgcctc cgcgcagaga ggtatttctg gtggtcgcat tcatatgtca    180

gttttaggaa ggcttgggac atttgaaact cagattctgc aaagagctcc tcttagatcc    240

tttacagaaa caccagcata ctttgcctca aaagatggga taagtaaaga tggttctgga    300

gatggaaata agaaatcagc aagtgaggga agtagtaaga aatcaggctc tgggaattct    360

gggaaaggtg gaaaccagct gcgctgtcct aaatgtggcg acttgtgcac acatgtagag    420

acctttgtat catccacccg ttttgtcaag tgtgaaaagt gtcatcattt ttttgttgtg    480

ctatctgaag cagactcaaa gaaaagcata attaaagaac ctgaatcagc agcagaagct    540

gtaaaattgg cattccaaca gaaaccacca cctcccccta agaagattta taactacctc    600

gacaagtatg ttgttggcca gtcatttgct aagaaggtgc tttcagttgc tgtgtacaat    660

cattataaga gaatatataa taatatccca gctaatctga gacagcaagc agaggttgag    720

aagcagacat cattaacacc aagagagtta gaaataagaa gacgggagga tgagtacaga    780

tttacaaaat tgcttcagat tgctggaatt agcccacatg gtaatgcttt aggagcatca    840

atgcagcaac aggtaaatca acaaatacct caggaaaaac gaggaggtga agtattggat    900

tcttctcatg atgacataaa acttgaaaaa agtaatattt tgctgcttgg accaactggg    960

tcaggtaaaa ctctgctggc acaaacccta gctaaatgcc ttgatgtccc ttttgctatc   1020

tgtgactgta caactttgac tcaggctgga tatgtaggcg aagatattga atctgtgatt   1080

gcaaaactac tccaagatgc caattataat gtggaaaaag cacaacaagg aattgtcttt   1140

ctggatgaag tagataagat tggcagtgtg ccaggcattc atcaattacg ggatgtaggt   1200

ggagaaggcg ttcagcaagg cttattaaaa ctactagaag gcacaatagt caatgttcca   1260

gaaaagaatt cccgaaagct ccgtggagaa acagttcaag ttgatacaac aaacatcctg   1320

tttgtggcat ctggtgcttt caatggttta gacagaatca tcagcaggag gaaaaatgaa   1380

aagtatcttg gatttggaac accatctaat ctgggaaaag gcagaagggc tgcagctgct   1440

gcagaccttg ctaatcgaag tggggaatcg aatactcacc aagacattga agaaaaagat   1500

cggttattgc gtcatgtgga agccagagat ctgattgagt ttggcatgat tcctgagttt   1560

gtgggacggt tgcctgtggt ggttccattg catagcctag atgagaaaac acttgtacaa   1620

atattaactg agccacgaaa tgctgttatt cctcagtacc aggccttatt cagcatggat   1680

aagtgtgaac tgaatgttac tgaggatgct ttgaaagcta tagccagatt ggcactagaa   1740

cgaaaaacag gtgcacgagg ccttcggtcc ataatggaaa agctgttact agaaccaatg   1800

tttgaagtcc ctaattctga tatcgtatgt gtggaggttg acaaagaagt agtagaagga   1860

aaaaaggaac caggatacat ccgggctcca acaaaagaat cctctgaaga ggagtatgac   1920

tctggagttg aagaagaagg atggccccgc caagcagatg ctgcaaacag ctaaactgtc   1980

atattgctgt cttgtatata cagcttttcc ttcttttgtt taggatcata attgtctcta   2040

cagtctgata ttaaaggcat tggatctatc ttggatatca tacatggtca gagaagcctt   2100

taggagaaga atcagatcat gtatataatt gtaacatcac attgatttta cggaagatgt   2160

tatatggact ttaatgacac aatgtttaga gataaaatgt acattatttt ggttcagttt   2220

tttaaaaaaa atatgcttta acaaaattct taggaattct tttaagcaat gcaggtattg   2280

cgataactgt agattttaca ataatgttac tctacaaatg ggaaaataaa ttctttaaaa   2340

ttgaatattg a                                                        2351


<210>  3287
<211>  633
<212>  PRT
<213>  Homosapiens

<400>  3287

Met Pro Ser Cys Gly Ala Cys Thr Cys Gly Ala Ala Ala Val Arg Leu 
1               5                   10                  15      


Ile Thr Ser Ser Leu Ala Ser Ala Gln Arg Gly Ile Ser Gly Gly Arg 
            20                  25                  30          


Ile His Met Ser Val Leu Gly Arg Leu Gly Thr Phe Glu Thr Gln Ile 
        35                  40                  45              


Leu Gln Arg Ala Pro Leu Arg Ser Phe Thr Glu Thr Pro Ala Tyr Phe 
    50                  55                  60                  


Ala Ser Lys Asp Gly Ile Ser Lys Asp Gly Ser Gly Asp Gly Asn Lys 
65                  70                  75                  80  


Lys Ser Ala Ser Glu Gly Ser Ser Lys Lys Ser Gly Ser Gly Asn Ser 
                85                  90                  95      


Gly Lys Gly Gly Asn Gln Leu Arg Cys Pro Lys Cys Gly Asp Leu Cys 
            100                 105                 110         


Thr His Val Glu Thr Phe Val Ser Ser Thr Arg Phe Val Lys Cys Glu 
        115                 120                 125             


Lys Cys His His Phe Phe Val Val Leu Ser Glu Ala Asp Ser Lys Lys 
    130                 135                 140                 


Ser Ile Ile Lys Glu Pro Glu Ser Ala Ala Glu Ala Val Lys Leu Ala 
145                 150                 155                 160 


Phe Gln Gln Lys Pro Pro Pro Pro Pro Lys Lys Ile Tyr Asn Tyr Leu 
                165                 170                 175     


Asp Lys Tyr Val Val Gly Gln Ser Phe Ala Lys Lys Val Leu Ser Val 
            180                 185                 190         


Ala Val Tyr Asn His Tyr Lys Arg Ile Tyr Asn Asn Ile Pro Ala Asn 
        195                 200                 205             


Leu Arg Gln Gln Ala Glu Val Glu Lys Gln Thr Ser Leu Thr Pro Arg 
    210                 215                 220                 


Glu Leu Glu Ile Arg Arg Arg Glu Asp Glu Tyr Arg Phe Thr Lys Leu 
225                 230                 235                 240 


Leu Gln Ile Ala Gly Ile Ser Pro His Gly Asn Ala Leu Gly Ala Ser 
                245                 250                 255     


Met Gln Gln Gln Val Asn Gln Gln Ile Pro Gln Glu Lys Arg Gly Gly 
            260                 265                 270         


Glu Val Leu Asp Ser Ser His Asp Asp Ile Lys Leu Glu Lys Ser Asn 
        275                 280                 285             


Ile Leu Leu Leu Gly Pro Thr Gly Ser Gly Lys Thr Leu Leu Ala Gln 
    290                 295                 300                 


Thr Leu Ala Lys Cys Leu Asp Val Pro Phe Ala Ile Cys Asp Cys Thr 
305                 310                 315                 320 


Thr Leu Thr Gln Ala Gly Tyr Val Gly Glu Asp Ile Glu Ser Val Ile 
                325                 330                 335     


Ala Lys Leu Leu Gln Asp Ala Asn Tyr Asn Val Glu Lys Ala Gln Gln 
            340                 345                 350         


Gly Ile Val Phe Leu Asp Glu Val Asp Lys Ile Gly Ser Val Pro Gly 
        355                 360                 365             


Ile His Gln Leu Arg Asp Val Gly Gly Glu Gly Val Gln Gln Gly Leu 
    370                 375                 380                 


Leu Lys Leu Leu Glu Gly Thr Ile Val Asn Val Pro Glu Lys Asn Ser 
385                 390                 395                 400 


Arg Lys Leu Arg Gly Glu Thr Val Gln Val Asp Thr Thr Asn Ile Leu 
                405                 410                 415     


Phe Val Ala Ser Gly Ala Phe Asn Gly Leu Asp Arg Ile Ile Ser Arg 
            420                 425                 430         


Arg Lys Asn Glu Lys Tyr Leu Gly Phe Gly Thr Pro Ser Asn Leu Gly 
        435                 440                 445             


Lys Gly Arg Arg Ala Ala Ala Ala Ala Asp Leu Ala Asn Arg Ser Gly 
    450                 455                 460                 


Glu Ser Asn Thr His Gln Asp Ile Glu Glu Lys Asp Arg Leu Leu Arg 
465                 470                 475                 480 


His Val Glu Ala Arg Asp Leu Ile Glu Phe Gly Met Ile Pro Glu Phe 
                485                 490                 495     


Val Gly Arg Leu Pro Val Val Val Pro Leu His Ser Leu Asp Glu Lys 
            500                 505                 510         


Thr Leu Val Gln Ile Leu Thr Glu Pro Arg Asn Ala Val Ile Pro Gln 
        515                 520                 525             


Tyr Gln Ala Leu Phe Ser Met Asp Lys Cys Glu Leu Asn Val Thr Glu 
    530                 535                 540                 


Asp Ala Leu Lys Ala Ile Ala Arg Leu Ala Leu Glu Arg Lys Thr Gly 
545                 550                 555                 560 


Ala Arg Gly Leu Arg Ser Ile Met Glu Lys Leu Leu Leu Glu Pro Met 
                565                 570                 575     


Phe Glu Val Pro Asn Ser Asp Ile Val Cys Val Glu Val Asp Lys Glu 
            580                 585                 590         


Val Val Glu Gly Lys Lys Glu Pro Gly Tyr Ile Arg Ala Pro Thr Lys 
        595                 600                 605             


Glu Ser Ser Glu Glu Glu Tyr Asp Ser Gly Val Glu Glu Glu Gly Trp 
    610                 615                 620                 


Pro Arg Gln Ala Asp Ala Ala Asn Ser 
625                 630             


<210>  3288
<211>  4436
<212>  DNA
<213>  Homosapiens

<400>  3288
aggcgaaggc ttggaccccc agctgaggag tcctgctcaa gacacggtca ctggatctga     60

gaaacttccc aggggaccgc attccagagt cagtgactct gtgaagcacc cacatctacc    120

tcttgccacg ttcccacggg cttgggggaa agatggtggg gaccaaggcc tgggtgttct    180

ccttcctggt cctggaagtc acatctgtgt tggggagaca gacgatgctc acccagtcag    240

taagaagagt ccagcctggg aagaagaacc ccagcatctt tgccaagcct gccgacaccc    300

tggagagccc tggtgagtgg acaacatggt tcaacatcga ctacccaggc gggaagggcg    360

actatgagcg gctggacgcc attcgcttct actatgggga ccgtgtatgt gcccgtcccc    420

tgcggctaga ggctcggacc actgactgga cacctgcggg cagcactggc caggtggtcc    480

atggtagtcc ccgtgagggt ttctggtgcc tcaacaggga gcagcggcct ggccagaact    540

gctctaatta caccgtacgc ttcctctgcc caccaggatc cctgcgccga gacacagagc    600

gcatctggag cccatggtct ccctggagca agtgctcagc tgcctgtggt cagactgggg    660

tccagactcg cacacgcatt tgcttggcag agatggtgtc gctgtgcagt gaggccagcg    720

aagagggtca gcactgcatg ggccaggact gtacagcctg tgacctgacc tgcccaatgg    780

gccaggtgaa tgctgactgt gatgcctgca tgtgccagga cttcatgctt catggggctg    840

tctcccttcc cggaggtgcc ccagcctcag gggctgctat ctacctcctg accaagacgc    900

cgaagctgct gacccagaca gacagtgatg ggagattccg aatccctggc ttgtgccctg    960

atggcaaaag catcctgaag atcacaaagg tcaagtttgc ccccattgta ctcacaatgc   1020

ccaagactag cctgaaggca gccaccatca aggcagagtt tgtgagggca gagactccat   1080

acatggtgat gaaccctgag acaaaagcac ggagagctgg gcagagcgtg tctctgtgct   1140

gtaaggccac agggaagccc aggccagaca agtatttttg gtatcataat gacacattgc   1200

tggatccttc cctctacaag catgagagca agctggtgct gaggaaactg cagcagcacc   1260

aggctgggga gtacttttgc aaggcccaga gtgatgctgg ggctgtgaag tccaaggttg   1320

cccagctgat tgtcatagca tctgatgaga ctccttgcaa cccagttcct gagagctatc   1380

ttatccggct gccccatgat tgctttcaga atgccaccaa ctccttctac tatgacgtgg   1440

gacgctgccc tgttaagact tgtgcagggc agcaggataa tgggatcagg tgccgtgatg   1500

ctgtgcagaa ctgctgtggc atctccaaga cagaggaaag ggagatccag tgcagtggct   1560

acacgctacc caccaaggtg gccaaggagt gcagctgcca gcggtgtacg gaaactcgga   1620

gcatcgtgcg gggccgtgtc agtgctgctg acaatgggga gcccatgcgc tttggccatg   1680

tgtacatggg gaacagccgt gtaagcatga ctggctacaa gggcactttc accctccatg   1740

tcccccagga cactgagagg ctggtgctca catttgtgga caggctgcag aagtttgtca   1800

acaccaccaa agtgctacct ttcaacaaga aggggagtgc cgtgttccat gaaatcaaga   1860

tgcttcgtcg gaaagagccc atcactttgg aagccatgga gaccaacatc atccccctgg   1920

gggaagtggt tggtgaagac cccatggctg aactggagat tccatccagg agtttctaca   1980

ggcagaatgg ggagccctac ataggaaaag tgaaggccag tgtgaccttc ctggatcccc   2040

ggaatatttc cacagccaca gctgcccaga ctgacctgaa cttcatcaat gacgaaggag   2100

acactttccc ccttcggacg tatggcatgt tctctgtgga cttcagagat gaggtcacct   2160

cagagccact taatgctggc aaagtgaagg tccaccttga ctcgacccag gtcaagatgc   2220

cagagcacat atccacagtg aaactctggt cactcaatcc agacacaggg ctgtgggagg   2280

aggaaggtga tttcaaattt gaaaatcaaa ggaggaacaa aagagaagac agaaccttcc   2340

tggtgggcaa cctggagatt cgtgagagga ggctctttaa cctggatgtt cctgaaagca   2400

ggcggtgctt tgttaaggtg agggcctacc ggagtgagag gttcttgcct agtgagcaga   2460

tccagggggt tgtgatctcc gtgattaacc tggagcctag aactggcttc ttgtccaacc   2520

ctagggcctg gggccgcttt gacagtgtca tcacaggccc caacggggcc tgtgtgcctg   2580

ccttctgtga tgaccagtcc cctgatgcct actctgccta tgtcttggca agcctggctg   2640

gggaggaact gcaagcagtg gagtcttctc ctaaattcaa cccaaatgca attggcgtcc   2700

ctcagcccta tctcaacaag ctcaactacc gtcggacgga ccatgaggat ccacgggtta   2760

aaaagacagc tttccagatt agcatggcca agccaaggcc caactcagct gaggagagca   2820

atgggcccat ctatgccttt gagaacctcc gggcatgtga agaggcacca cccagtgcag   2880

cccacttccg gttctaccag attgaggggg atcgatatga ctacaacaca gtccccttca   2940

acgaagatga ccctatgagc tggactgaag actatctggc atggtggcca aagccgatgg   3000

aattcagggc ctgctatatc aaggtgaaga ttgtggggcc actggaagtg aatgtgcgat   3060

cccgcaacat ggggggcact catcggcgga cagtggggaa gctgtatgga atccgagatg   3120

tgaggagcac tcgggacagg gaccagccca atgtctcagc tgcctgtctg gagttcaagt   3180

gcagtgggat gctctatgat caggaccgtg tggaccgcac cctggtgaag gtcatccccc   3240

agggcagctg ccgtcgagcc agtgtgaacc ccatgctgca tgagtacctg gtcaaccact   3300

tgccacttgc agtcaacaac gacaccagtg agtacaccat gctggcaccc ttggacccac   3360

tgggccacaa ctatggcatc tacactgtca ctgaccagga ccctcgcacg gccaaggaga   3420

tcgcgctcgg ccggtgcttt gatggcacat ccgatggctc ctccagaatc atgaagagca   3480

atgtgggagt agccctcacc ttcaactgtg tagagaggca agtaggccgc cagagtgcct   3540

tccagtacct ccaaagcacc ccagcccagt cccctgctgc aggcactgtc caaggaagag   3600

tgccctcgag gaggcagcag cgagcgagca ggggtggcca gcgccagggt ggagtggtgg   3660

cctctctgag atttcctaga gttgctcaac agcccctgat caactaagtt ttgtggtact   3720

tcaccctctt ctgccctcat ttcatgtgac agccattgtg agactgatgc acaaactgtc   3780

acttggttaa tttaagcact tctgttttcg tgaatttgct tgtttgtttc ttcatgcctt   3840

tacttacttt gtcccatgct actgattggc acgtggcccc cacaatggca caataaagcc   3900

cctttgtgaa actgttcttt aaatgaaaca caagaaattg gccactggta aaactctgca   3960

gcttcaactg tacttcattt aatgccatta atgcaaatat acttcctctt ctttttgcat   4020

ggttttgccc acctctgcaa tagtgataat ctgatgctga agatcaaata accaatataa   4080

agcatatttc ttggccttgc tccacaggac ataggcaagc cttgatcata gttcatacat   4140

ataaatggtg gtgaaataaa gaaataaaac acaatacttt tacttgaatg taaataactt   4200

atttatttct ttgctaaatt tggaattcta gtgcacattc aaagttaagc tattaaatat   4260

agggtgatca tagttcctct accaagtctg gaaagaacat ctcctggtat ccacaattac   4320

accaggttgc taactgtatt tgtacatttc cctttgcatt cgcttttgtt cttgctagaa   4380

acccagtgta gcccagggca gatgtcaata aatgcatact ctgtatttcg aaaaaa       4436


<210>  3289
<211>  1184
<212>  PRT
<213>  Homosapiens

<400>  3289

Met Val Gly Thr Lys Ala Trp Val Phe Ser Phe Leu Val Leu Glu Val 
1               5                   10                  15      


Thr Ser Val Leu Gly Arg Gln Thr Met Leu Thr Gln Ser Val Arg Arg 
            20                  25                  30          


Val Gln Pro Gly Lys Lys Asn Pro Ser Ile Phe Ala Lys Pro Ala Asp 
        35                  40                  45              


Thr Leu Glu Ser Pro Gly Glu Trp Thr Thr Trp Phe Asn Ile Asp Tyr 
    50                  55                  60                  


Pro Gly Gly Lys Gly Asp Tyr Glu Arg Leu Asp Ala Ile Arg Phe Tyr 
65                  70                  75                  80  


Tyr Gly Asp Arg Val Cys Ala Arg Pro Leu Arg Leu Glu Ala Arg Thr 
                85                  90                  95      


Thr Asp Trp Thr Pro Ala Gly Ser Thr Gly Gln Val Val His Gly Ser 
            100                 105                 110         


Pro Arg Glu Gly Phe Trp Cys Leu Asn Arg Glu Gln Arg Pro Gly Gln 
        115                 120                 125             


Asn Cys Ser Asn Tyr Thr Val Arg Phe Leu Cys Pro Pro Gly Ser Leu 
    130                 135                 140                 


Arg Arg Asp Thr Glu Arg Ile Trp Ser Pro Trp Ser Pro Trp Ser Lys 
145                 150                 155                 160 


Cys Ser Ala Ala Cys Gly Gln Thr Gly Val Gln Thr Arg Thr Arg Ile 
                165                 170                 175     


Cys Leu Ala Glu Met Val Ser Leu Cys Ser Glu Ala Ser Glu Glu Gly 
            180                 185                 190         


Gln His Cys Met Gly Gln Asp Cys Thr Ala Cys Asp Leu Thr Cys Pro 
        195                 200                 205             


Met Gly Gln Val Asn Ala Asp Cys Asp Ala Cys Met Cys Gln Asp Phe 
    210                 215                 220                 


Met Leu His Gly Ala Val Ser Leu Pro Gly Gly Ala Pro Ala Ser Gly 
225                 230                 235                 240 


Ala Ala Ile Tyr Leu Leu Thr Lys Thr Pro Lys Leu Leu Thr Gln Thr 
                245                 250                 255     


Asp Ser Asp Gly Arg Phe Arg Ile Pro Gly Leu Cys Pro Asp Gly Lys 
            260                 265                 270         


Ser Ile Leu Lys Ile Thr Lys Val Lys Phe Ala Pro Ile Val Leu Thr 
        275                 280                 285             


Met Pro Lys Thr Ser Leu Lys Ala Ala Thr Ile Lys Ala Glu Phe Val 
    290                 295                 300                 


Arg Ala Glu Thr Pro Tyr Met Val Met Asn Pro Glu Thr Lys Ala Arg 
305                 310                 315                 320 


Arg Ala Gly Gln Ser Val Ser Leu Cys Cys Lys Ala Thr Gly Lys Pro 
                325                 330                 335     


Arg Pro Asp Lys Tyr Phe Trp Tyr His Asn Asp Thr Leu Leu Asp Pro 
            340                 345                 350         


Ser Leu Tyr Lys His Glu Ser Lys Leu Val Leu Arg Lys Leu Gln Gln 
        355                 360                 365             


His Gln Ala Gly Glu Tyr Phe Cys Lys Ala Gln Ser Asp Ala Gly Ala 
    370                 375                 380                 


Val Lys Ser Lys Val Ala Gln Leu Ile Val Ile Ala Ser Asp Glu Thr 
385                 390                 395                 400 


Pro Cys Asn Pro Val Pro Glu Ser Tyr Leu Ile Arg Leu Pro His Asp 
                405                 410                 415     


Cys Phe Gln Asn Ala Thr Asn Ser Phe Tyr Tyr Asp Val Gly Arg Cys 
            420                 425                 430         


Pro Val Lys Thr Cys Ala Gly Gln Gln Asp Asn Gly Ile Arg Cys Arg 
        435                 440                 445             


Asp Ala Val Gln Asn Cys Cys Gly Ile Ser Lys Thr Glu Glu Arg Glu 
    450                 455                 460                 


Ile Gln Cys Ser Gly Tyr Thr Leu Pro Thr Lys Val Ala Lys Glu Cys 
465                 470                 475                 480 


Ser Cys Gln Arg Cys Thr Glu Thr Arg Ser Ile Val Arg Gly Arg Val 
                485                 490                 495     


Ser Ala Ala Asp Asn Gly Glu Pro Met Arg Phe Gly His Val Tyr Met 
            500                 505                 510         


Gly Asn Ser Arg Val Ser Met Thr Gly Tyr Lys Gly Thr Phe Thr Leu 
        515                 520                 525             


His Val Pro Gln Asp Thr Glu Arg Leu Val Leu Thr Phe Val Asp Arg 
    530                 535                 540                 


Leu Gln Lys Phe Val Asn Thr Thr Lys Val Leu Pro Phe Asn Lys Lys 
545                 550                 555                 560 


Gly Ser Ala Val Phe His Glu Ile Lys Met Leu Arg Arg Lys Glu Pro 
                565                 570                 575     


Ile Thr Leu Glu Ala Met Glu Thr Asn Ile Ile Pro Leu Gly Glu Val 
            580                 585                 590         


Val Gly Glu Asp Pro Met Ala Glu Leu Glu Ile Pro Ser Arg Ser Phe 
        595                 600                 605             


Tyr Arg Gln Asn Gly Glu Pro Tyr Ile Gly Lys Val Lys Ala Ser Val 
    610                 615                 620                 


Thr Phe Leu Asp Pro Arg Asn Ile Ser Thr Ala Thr Ala Ala Gln Thr 
625                 630                 635                 640 


Asp Leu Asn Phe Ile Asn Asp Glu Gly Asp Thr Phe Pro Leu Arg Thr 
                645                 650                 655     


Tyr Gly Met Phe Ser Val Asp Phe Arg Asp Glu Val Thr Ser Glu Pro 
            660                 665                 670         


Leu Asn Ala Gly Lys Val Lys Val His Leu Asp Ser Thr Gln Val Lys 
        675                 680                 685             


Met Pro Glu His Ile Ser Thr Val Lys Leu Trp Ser Leu Asn Pro Asp 
    690                 695                 700                 


Thr Gly Leu Trp Glu Glu Glu Gly Asp Phe Lys Phe Glu Asn Gln Arg 
705                 710                 715                 720 


Arg Asn Lys Arg Glu Asp Arg Thr Phe Leu Val Gly Asn Leu Glu Ile 
                725                 730                 735     


Arg Glu Arg Arg Leu Phe Asn Leu Asp Val Pro Glu Ser Arg Arg Cys 
            740                 745                 750         


Phe Val Lys Val Arg Ala Tyr Arg Ser Glu Arg Phe Leu Pro Ser Glu 
        755                 760                 765             


Gln Ile Gln Gly Val Val Ile Ser Val Ile Asn Leu Glu Pro Arg Thr 
    770                 775                 780                 


Gly Phe Leu Ser Asn Pro Arg Ala Trp Gly Arg Phe Asp Ser Val Ile 
785                 790                 795                 800 


Thr Gly Pro Asn Gly Ala Cys Val Pro Ala Phe Cys Asp Asp Gln Ser 
                805                 810                 815     


Pro Asp Ala Tyr Ser Ala Tyr Val Leu Ala Ser Leu Ala Gly Glu Glu 
            820                 825                 830         


Leu Gln Ala Val Glu Ser Ser Pro Lys Phe Asn Pro Asn Ala Ile Gly 
        835                 840                 845             


Val Pro Gln Pro Tyr Leu Asn Lys Leu Asn Tyr Arg Arg Thr Asp His 
    850                 855                 860                 


Glu Asp Pro Arg Val Lys Lys Thr Ala Phe Gln Ile Ser Met Ala Lys 
865                 870                 875                 880 


Pro Arg Pro Asn Ser Ala Glu Glu Ser Asn Gly Pro Ile Tyr Ala Phe 
                885                 890                 895     


Glu Asn Leu Arg Ala Cys Glu Glu Ala Pro Pro Ser Ala Ala His Phe 
            900                 905                 910         


Arg Phe Tyr Gln Ile Glu Gly Asp Arg Tyr Asp Tyr Asn Thr Val Pro 
        915                 920                 925             


Phe Asn Glu Asp Asp Pro Met Ser Trp Thr Glu Asp Tyr Leu Ala Trp 
    930                 935                 940                 


Trp Pro Lys Pro Met Glu Phe Arg Ala Cys Tyr Ile Lys Val Lys Ile 
945                 950                 955                 960 


Val Gly Pro Leu Glu Val Asn Val Arg Ser Arg Asn Met Gly Gly Thr 
                965                 970                 975     


His Arg Arg Thr Val Gly Lys Leu Tyr Gly Ile Arg Asp Val Arg Ser 
            980                 985                 990         


Thr Arg Asp Arg Asp Gln Pro Asn  Val Ser Ala Ala Cys  Leu Glu Phe 
        995                 1000                 1005             


Lys Cys  Ser Gly Met Leu Tyr  Asp Gln Asp Arg Val  Asp Arg Thr 
    1010                 1015                 1020             


Leu Val  Lys Val Ile Pro Gln  Gly Ser Cys Arg Arg  Ala Ser Val 
    1025                 1030                 1035             


Asn Pro  Met Leu His Glu Tyr  Leu Val Asn His Leu  Pro Leu Ala 
    1040                 1045                 1050             


Val Asn  Asn Asp Thr Ser Glu  Tyr Thr Met Leu Ala  Pro Leu Asp 
    1055                 1060                 1065             


Pro Leu  Gly His Asn Tyr Gly  Ile Tyr Thr Val Thr  Asp Gln Asp 
    1070                 1075                 1080             


Pro Arg  Thr Ala Lys Glu Ile  Ala Leu Gly Arg Cys  Phe Asp Gly 
    1085                 1090                 1095             


Thr Ser  Asp Gly Ser Ser Arg  Ile Met Lys Ser Asn  Val Gly Val 
    1100                 1105                 1110             


Ala Leu  Thr Phe Asn Cys Val  Glu Arg Gln Val Gly  Arg Gln Ser 
    1115                 1120                 1125             


Ala Phe  Gln Tyr Leu Gln Ser  Thr Pro Ala Gln Ser  Pro Ala Ala 
    1130                 1135                 1140             


Gly Thr  Val Gln Gly Arg Val  Pro Ser Arg Arg Gln  Gln Arg Ala 
    1145                 1150                 1155             


Ser Arg  Gly Gly Gln Arg Gln  Gly Gly Val Val Ala  Ser Leu Arg 
    1160                 1165                 1170             


Phe Pro  Arg Val Ala Gln Gln  Pro Leu Ile Asn 
    1175                 1180                 


<210>  3290
<211>  2551
<212>  DNA
<213>  Homosapiens

<400>  3290
caacctcccc gccgacccgc ggtccaggcc tcggtctctc tcttcggcgg cgagccgcgg     60

cccagacccc ggcagaggac acttgtcggc acgttctcac ccctgtcatc tcagccccct    120

gcctagctcc accccaggct tgggaacccg gcccctgacg gcccattgtc cgcgggccca    180

gcccccgcgc tgaacgcacg ctcgcccttg cccctaacca gcgcgtctac cccggcaacg    240

cgcagtgacc tgggatgcag ccctcaggct gggcggccgc cagggaggcg gcgggccgcg    300

acatgctggc cgccgacctc cggtgcagcc tcttcgcctc ggccctgcag agctacaagc    360

gcgactcggt gctgcggccc ttccccgcgt cctacgcccg cggcgactgt aaggactttg    420

aagccctgct tgcagatgcc agcaagttac ctaacctgaa agaacttctc cagtcctccg    480

gagacaacca caaacgggcc tgggacctgg tgagctggat tttatcctca aaggtcctga    540

caatccacag tgcagggaag gcagagtttg aaaagatcca aaagctgact ggggctcctc    600

acacgcctgt tcctgcaccg gacttcctgt ttgaaattga gtactttgac ccagccaacg    660

ccaaatttta tgagaccaaa ggagaacgag acctaatcta tgcatttcat ggtagccgcc    720

tagaaaactt ccattccatt atccacaatg gcctgcactg ccatctgaac aagacatcct    780

tgttcggaga ggggacctac ctcaccagtg acttgagcct ggccctcata tacagccccc    840

atggccatgg gtggcagcac agcctcctcg gccccatcct tagctgtgtg gccgtgtgtg    900

aggtcattga ccatccggac gtcaagtgcc aaaccaagaa gaaggattcc aaggagatag    960

atcgcagacg agcgagaatc aaacatagtg aagggggaga catccctccc aagtacttcg   1020

tggtcaccaa taaccagctg ctgcgagtga agtacctcct ggtgtattca cagaagccac   1080

ccaagagcag ggcttcgagc cagctctcct ggttttccag ccattggttt accgtcatga   1140

tatccctgta tctgctgctg ctgctcatag tgagtgtcat caactcctct gctttccaac   1200

acttttggaa tcgtgcgaaa agataatctt tctgggcctg gtgtgggggc tacctcaact   1260

atgtgcctta tggtaacttg ttctgtacct cctatgcctc atgtccagcc aggttgagcc   1320

taggggccag ttgggggacc acaggacaat tttcatatgg cctaaatgta tccattgcct   1380

ttgatgatgt tcccagccat actccagtca acggggacta ctagtccctc actcttaggt   1440

tttaggggag tccttccatc tgctccttct taaactgtcc tagggagttg gcttttcagc   1500

cagggccaaa ggaaaaagcc ctgctgcatt taaaaacaaa gtgtccaagc tgtcagtggt   1560

gtgtttacaa tctctcctgg cagaggttgg ccctttctct aatgccttct ggaaggcgga   1620

aaatgtggga actataaatc actaggcggt tgccttgttt tgacttgaga cacccaagag   1680

gaacagtcat gtttctcata aaaatcagtg ggatcatttt tgaattccat cagcctttgt   1740

atgtgagtgc aaaacatttt aacagttttc tcaaatcaac aaacagcctt ctcctatagc   1800

tgtacttgcc cccctcccca aaaaaccatg gatgagaaag aaaggagtca ggggcctgat   1860

aaaaaataca gacttaatga gcaactcaag atgagaaaac tgctcttttt ccaaaaatta   1920

ccaactgctg attacagctg aaatggaacc aaatgtttgt tttctgattt ttttttaata   1980

gctgtttaac aaattagtct ttgctgagta aaaggggaaa tttctaaacc tagtgcactg   2040

tttggccagt gtccacagcc tcttttctgg ctgtgtttta gagaaaggga tttgagctat   2100

aggctcgcct cctgttctca ttctcacaaa gctgccttga ctgtggcctg caaccacgag   2160

tgccatgctt tcaggtcttc tgtggcctac tggccttcaa gacagaggcc tgccccagtg   2220

tgccacagat ccatgtggat ggagcctcct tcagaggggt cacaggtctt tgagactcag   2280

cctgggcttt aatgtgtagg aaaagccttc tggccaccca gagagccgga gccctgcttg   2340

ctgtattctc tgctcccttc ttcctgctgg gttttagcca taatagggcc cggtacgatt   2400

tgggagtgac atttctgtaa agaagaggaa aaatcatttt tctataattt gtaaagttgt   2460

gaaagagcca ctaccacagt ttttacattg attattggaa catttcagaa taaataaaga   2520

tattttctta atgaaaaaaa aaaaaaaaaa a                                  2551


<210>  3291
<211>  323
<212>  PRT
<213>  Homosapiens

<400>  3291

Met Gln Pro Ser Gly Trp Ala Ala Ala Arg Glu Ala Ala Gly Arg Asp 
1               5                   10                  15      


Met Leu Ala Ala Asp Leu Arg Cys Ser Leu Phe Ala Ser Ala Leu Gln 
            20                  25                  30          


Ser Tyr Lys Arg Asp Ser Val Leu Arg Pro Phe Pro Ala Ser Tyr Ala 
        35                  40                  45              


Arg Gly Asp Cys Lys Asp Phe Glu Ala Leu Leu Ala Asp Ala Ser Lys 
    50                  55                  60                  


Leu Pro Asn Leu Lys Glu Leu Leu Gln Ser Ser Gly Asp Asn His Lys 
65                  70                  75                  80  


Arg Ala Trp Asp Leu Val Ser Trp Ile Leu Ser Ser Lys Val Leu Thr 
                85                  90                  95      


Ile His Ser Ala Gly Lys Ala Glu Phe Glu Lys Ile Gln Lys Leu Thr 
            100                 105                 110         


Gly Ala Pro His Thr Pro Val Pro Ala Pro Asp Phe Leu Phe Glu Ile 
        115                 120                 125             


Glu Tyr Phe Asp Pro Ala Asn Ala Lys Phe Tyr Glu Thr Lys Gly Glu 
    130                 135                 140                 


Arg Asp Leu Ile Tyr Ala Phe His Gly Ser Arg Leu Glu Asn Phe His 
145                 150                 155                 160 


Ser Ile Ile His Asn Gly Leu His Cys His Leu Asn Lys Thr Ser Leu 
                165                 170                 175     


Phe Gly Glu Gly Thr Tyr Leu Thr Ser Asp Leu Ser Leu Ala Leu Ile 
            180                 185                 190         


Tyr Ser Pro His Gly His Gly Trp Gln His Ser Leu Leu Gly Pro Ile 
        195                 200                 205             


Leu Ser Cys Val Ala Val Cys Glu Val Ile Asp His Pro Asp Val Lys 
    210                 215                 220                 


Cys Gln Thr Lys Lys Lys Asp Ser Lys Glu Ile Asp Arg Arg Arg Ala 
225                 230                 235                 240 


Arg Ile Lys His Ser Glu Gly Gly Asp Ile Pro Pro Lys Tyr Phe Val 
                245                 250                 255     


Val Thr Asn Asn Gln Leu Leu Arg Val Lys Tyr Leu Leu Val Tyr Ser 
            260                 265                 270         


Gln Lys Pro Pro Lys Ser Arg Ala Ser Ser Gln Leu Ser Trp Phe Ser 
        275                 280                 285             


Ser His Trp Phe Thr Val Met Ile Ser Leu Tyr Leu Leu Leu Leu Leu 
    290                 295                 300                 


Ile Val Ser Val Ile Asn Ser Ser Ala Phe Gln His Phe Trp Asn Arg 
305                 310                 315                 320 


Ala Lys Arg 
            


<210>  3292
<211>  3103
<212>  DNA
<213>  Homosapiens

<400>  3292
gtgggtgcaa gatggcgcaa gcggcgctcc ccctgcgccc cccgcgctgc tgagcaggca     60

tgcggcccca gtcccccacc gcctgggctc ggccccggcc ggagccccag ccccggcccc    120

ggcgccggcc ccgcgggacg ctgtgagccg cgagaggccc gggagccgcg cgtcgccgag    180

ccgagctgac cgagagcccc atggctgtgc agcgcgccgc gtctccgcgc cgcccgcccg    240

ccccgctctg gccccggctc ctgctgccgc tgctgttgct gctgctgccc gcgccgagcg    300

agggtcttgg ccactctgcc gaactggcat ttgctgtgga gccaagtgat gatgttgccg    360

tccccgggca gcctatagtg ctggactgca gggtggaggg gacccctcca gtgcgaatca    420

cctggaggaa gaatggggta gagctgccag agagtaccca ctccaccttg ctggccaatg    480

ggtccttgat gatccgtcac ttcaggctgg agccgggagg cagcccttcg gatgaaggtg    540

actatgagtg tgtggcccag aaccgctttg ggctggtggt cagccggaag gctcgcatcc    600

aagctgcaac catgtcggac ttccacgtgc atccccaggc caccgtgggt gaggagggtg    660

gtgtggcccg cttccagtgc caaatccatg ggcttcccaa acccctgatc acttgggaga    720

agaacagagt cccaattgac acggacaatg agaggtacac attgctgccc aagggggtcc    780

tgcagatcac aggacttcga gctgaggacg gtggcatctt ccactgtgtg gcctcaaaca    840

tcgccagtat ccggatcagc cacggggcca ggctcactgt gtcaggctcg ggctctgggg    900

cctacaagga gccagccatc ctcgtggggc ctgagaacct caccctgaca gtgcaccaga    960

ccgcggtgct tgagtgtgtc gccacgggca acccgcgccc cattgtgtcc tggagccgcc   1020

tggatggtcg ccctatcggg gtggagggca tccaggtgct gggcacagga aacctcatca   1080

tctcagacgt gacggtccag cactctggcg tctacgtctg tgcagccaac agacctggca   1140

cccgggtgag gagaacggca cagggccggc tggtggtgca agccccagct gagtttgtgc   1200

agcatcccca gtccatctcc aggccagctg ggaccacagc catgttcacc tgccaagccc   1260

agggtgagcc accgcctcat gtcacgtggc tgaaaaatgg acaggtgctg gggccaggag   1320

gccacgtcag gctcaagaat aacaacagca cactgaccat ttctggaatc ggtcctgagg   1380

atgaagccat ttatcagtgt gtggccgaga acagtgcggg ctcatcacag gccagtgcca   1440

ggctgaccgt actgtgggct gaggggctcc ccgggcctcc ccgcaatgtg cgggcagtct   1500

ctgtgtcttc cactgaggtg cgtgtgtcct ggagtgagcc gctggccaac accaaggaga   1560

tcatcggcta cgtcctgcac atcaggaagg ctgctgaccc accggagctg gagtatcagg   1620

aggcagtcag caagagcacc tttcagcacc tggtcagcga cctggagccc tccacagcct   1680

acagtttcta catcaaggcc tacacaccaa ggggggccag ctcagcctct gtgcccaccc   1740

tagctagcac cctgggtgaa gcccctgccc cacccccact gtcagtgcga gtcctgggca   1800

gctcctcctt gcagctgctg tgggagcctt ggccccggct ggcccagcac gagggcggct   1860

tcaagctgtt ttaccgccca gcaagcaaga cctccttcac cggccccatc ctgctgcctg   1920

gaaccgtctc ctcctacaac ctcagccagc tcgaccccac tgcagtgtat gaggtgaagc   1980

tgctcgccta caaccagcat ggagatggca atgccacagt ccgctttgtg tctttgaggg   2040

gagcatctga gaggacagcc ttgagcccac catgtgactg ccggaaggag gaggccgcca   2100

accagacgtc caccacaggc atcgtcatcg gcatccacat cggggtcact tgcatcatct   2160

tctgtgtcct cttcctcctg ttcggccaaa ggggcagggt cctcctgtgt aaagatgtgg   2220

aaaaccagct gtcccctcca cagggtcccc ggagccagag ggaccctggc attctggccc   2280

taaatggggc gagacgggga cagcggggcc agctgggccg agacgagaaa cgtgtggata   2340

tgaaggagct ggagcagctg ttccccccgg ccagcgcagc agggcagccg gaccccagac   2400

ccacacagga tcctgcagcc cccgctccgt gtgaggagac ccagctctcc ttgctgccac   2460

ttcaggggtg cggcctgatg gaggggaaga cgacggaggc gaagaccaca gaggccacgg   2520

ctccctgcgc cggcctggcg gctgccccac cacccccaga tggaggccct ggcctcctca   2580

gtgaaggcca ggcttccagg cctgcagcgg cccgggttac ccagccagct cactcggaac   2640

agtagccagt gtctggcagg ctccagaggg tggacggagc ggggcccatt ctcaggtcaa   2700

aagcaagatt tctactgtca tgtgggattt ggatggtcct gggggctccc cagtatttct   2760

atcctgactg cctcttgggt tgtcaaaacc caaggcagcc ttgacaggga ccccccggcc   2820

ctaacaccca tcaggagttg gagcagttcc tgcaggagcc tgttccttcc ctgggctgac   2880

gcccccttgc ctctgcctgg tacccacatg acttggaact gaactaacat ttttctttaa   2940

aaagcaaaac ttaaaaaaaa aaaaaaagag gagagagata gaggaaggtg aattagactc   3000

caaaagatga ccctgctgta gctgggccct gacactgtca ccctccaccg actttgtttt   3060

ctcaggatgg atttttgctg ttttggctct cagcacctac ctc                     3103


<210>  3293
<211>  814
<212>  PRT
<213>  Homosapiens

<400>  3293

Met Ala Val Gln Arg Ala Ala Ser Pro Arg Arg Pro Pro Ala Pro Leu 
1               5                   10                  15      


Trp Pro Arg Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Pro Ala Pro 
            20                  25                  30          


Ser Glu Gly Leu Gly His Ser Ala Glu Leu Ala Phe Ala Val Glu Pro 
        35                  40                  45              


Ser Asp Asp Val Ala Val Pro Gly Gln Pro Ile Val Leu Asp Cys Arg 
    50                  55                  60                  


Val Glu Gly Thr Pro Pro Val Arg Ile Thr Trp Arg Lys Asn Gly Val 
65                  70                  75                  80  


Glu Leu Pro Glu Ser Thr His Ser Thr Leu Leu Ala Asn Gly Ser Leu 
                85                  90                  95      


Met Ile Arg His Phe Arg Leu Glu Pro Gly Gly Ser Pro Ser Asp Glu 
            100                 105                 110         


Gly Asp Tyr Glu Cys Val Ala Gln Asn Arg Phe Gly Leu Val Val Ser 
        115                 120                 125             


Arg Lys Ala Arg Ile Gln Ala Ala Thr Met Ser Asp Phe His Val His 
    130                 135                 140                 


Pro Gln Ala Thr Val Gly Glu Glu Gly Gly Val Ala Arg Phe Gln Cys 
145                 150                 155                 160 


Gln Ile His Gly Leu Pro Lys Pro Leu Ile Thr Trp Glu Lys Asn Arg 
                165                 170                 175     


Val Pro Ile Asp Thr Asp Asn Glu Arg Tyr Thr Leu Leu Pro Lys Gly 
            180                 185                 190         


Val Leu Gln Ile Thr Gly Leu Arg Ala Glu Asp Gly Gly Ile Phe His 
        195                 200                 205             


Cys Val Ala Ser Asn Ile Ala Ser Ile Arg Ile Ser His Gly Ala Arg 
    210                 215                 220                 


Leu Thr Val Ser Gly Ser Gly Ser Gly Ala Tyr Lys Glu Pro Ala Ile 
225                 230                 235                 240 


Leu Val Gly Pro Glu Asn Leu Thr Leu Thr Val His Gln Thr Ala Val 
                245                 250                 255     


Leu Glu Cys Val Ala Thr Gly Asn Pro Arg Pro Ile Val Ser Trp Ser 
            260                 265                 270         


Arg Leu Asp Gly Arg Pro Ile Gly Val Glu Gly Ile Gln Val Leu Gly 
        275                 280                 285             


Thr Gly Asn Leu Ile Ile Ser Asp Val Thr Val Gln His Ser Gly Val 
    290                 295                 300                 


Tyr Val Cys Ala Ala Asn Arg Pro Gly Thr Arg Val Arg Arg Thr Ala 
305                 310                 315                 320 


Gln Gly Arg Leu Val Val Gln Ala Pro Ala Glu Phe Val Gln His Pro 
                325                 330                 335     


Gln Ser Ile Ser Arg Pro Ala Gly Thr Thr Ala Met Phe Thr Cys Gln 
            340                 345                 350         


Ala Gln Gly Glu Pro Pro Pro His Val Thr Trp Leu Lys Asn Gly Gln 
        355                 360                 365             


Val Leu Gly Pro Gly Gly His Val Arg Leu Lys Asn Asn Asn Ser Thr 
    370                 375                 380                 


Leu Thr Ile Ser Gly Ile Gly Pro Glu Asp Glu Ala Ile Tyr Gln Cys 
385                 390                 395                 400 


Val Ala Glu Asn Ser Ala Gly Ser Ser Gln Ala Ser Ala Arg Leu Thr 
                405                 410                 415     


Val Leu Trp Ala Glu Gly Leu Pro Gly Pro Pro Arg Asn Val Arg Ala 
            420                 425                 430         


Val Ser Val Ser Ser Thr Glu Val Arg Val Ser Trp Ser Glu Pro Leu 
        435                 440                 445             


Ala Asn Thr Lys Glu Ile Ile Gly Tyr Val Leu His Ile Arg Lys Ala 
    450                 455                 460                 


Ala Asp Pro Pro Glu Leu Glu Tyr Gln Glu Ala Val Ser Lys Ser Thr 
465                 470                 475                 480 


Phe Gln His Leu Val Ser Asp Leu Glu Pro Ser Thr Ala Tyr Ser Phe 
                485                 490                 495     


Tyr Ile Lys Ala Tyr Thr Pro Arg Gly Ala Ser Ser Ala Ser Val Pro 
            500                 505                 510         


Thr Leu Ala Ser Thr Leu Gly Glu Ala Pro Ala Pro Pro Pro Leu Ser 
        515                 520                 525             


Val Arg Val Leu Gly Ser Ser Ser Leu Gln Leu Leu Trp Glu Pro Trp 
    530                 535                 540                 


Pro Arg Leu Ala Gln His Glu Gly Gly Phe Lys Leu Phe Tyr Arg Pro 
545                 550                 555                 560 


Ala Ser Lys Thr Ser Phe Thr Gly Pro Ile Leu Leu Pro Gly Thr Val 
                565                 570                 575     


Ser Ser Tyr Asn Leu Ser Gln Leu Asp Pro Thr Ala Val Tyr Glu Val 
            580                 585                 590         


Lys Leu Leu Ala Tyr Asn Gln His Gly Asp Gly Asn Ala Thr Val Arg 
        595                 600                 605             


Phe Val Ser Leu Arg Gly Ala Ser Glu Arg Thr Ala Leu Ser Pro Pro 
    610                 615                 620                 


Cys Asp Cys Arg Lys Glu Glu Ala Ala Asn Gln Thr Ser Thr Thr Gly 
625                 630                 635                 640 


Ile Val Ile Gly Ile His Ile Gly Val Thr Cys Ile Ile Phe Cys Val 
                645                 650                 655     


Leu Phe Leu Leu Phe Gly Gln Arg Gly Arg Val Leu Leu Cys Lys Asp 
            660                 665                 670         


Val Glu Asn Gln Leu Ser Pro Pro Gln Gly Pro Arg Ser Gln Arg Asp 
        675                 680                 685             


Pro Gly Ile Leu Ala Leu Asn Gly Ala Arg Arg Gly Gln Arg Gly Gln 
    690                 695                 700                 


Leu Gly Arg Asp Glu Lys Arg Val Asp Met Lys Glu Leu Glu Gln Leu 
705                 710                 715                 720 


Phe Pro Pro Ala Ser Ala Ala Gly Gln Pro Asp Pro Arg Pro Thr Gln 
                725                 730                 735     


Asp Pro Ala Ala Pro Ala Pro Cys Glu Glu Thr Gln Leu Ser Leu Leu 
            740                 745                 750         


Pro Leu Gln Gly Cys Gly Leu Met Glu Gly Lys Thr Thr Glu Ala Lys 
        755                 760                 765             


Thr Thr Glu Ala Thr Ala Pro Cys Ala Gly Leu Ala Ala Ala Pro Pro 
    770                 775                 780                 


Pro Pro Asp Gly Gly Pro Gly Leu Leu Ser Glu Gly Gln Ala Ser Arg 
785                 790                 795                 800 


Pro Ala Ala Ala Arg Val Thr Gln Pro Ala His Ser Glu Gln 
                805                 810                 


<210>  3294
<211>  6485
<212>  DNA
<213>  Homosapiens

<400>  3294
ctcgcccaag atggcgatgg aggggcgggt gaggcggcag cggccctggc ccccgcgccg     60

gccccagctc gggcccgggc ccccgaggcc gcgcccccgc ccgcggcgcc gcgcctcccc    120

gggccactga cgcccggcgc gctctccccc cgcggcggcg gccgaagcac ggggaggcgg    180

cggcggcggc ggcggcccga gcccagcccc atggcgcggg gggacgccgg ccgcggccgt    240

gggctcctcg cgttgacctt ctgcctgttg gccgcgcgcg gggagctgct gttgccccag    300

gagacgactg tggagctgag ctgtggagtg gggccactgc aagtgatcct gggcccagag    360

caggctgcag tgctaaactg tagcctgggg gctgctgccg ctggaccccc caccagggtg    420

acctggagca aggatgggga caccctgctg gagcacgacc acttacacct gctgcccaat    480

ggttccctgt ggctgtccca gccactagca cccaatggca gtgacgagtc agtccctgag    540

gctgtggggg tcattgaagg caactattcg tgcctagccc acggccccct cggagtgctg    600

gccagccaga ctgctgtcgt caagcttgcc acactcgcag acttctctct gcacccggag    660

tctcagacgg tggaggagaa cgggacagct cgctttgagt gccacattga agggctgcca    720

gctcccatca ttacttggga gaaggaccag gtgacattgc ctgaggagcc tcggctcatc    780

gtgcttccca acggcgtcct tcagatcctg gatgttcagg agagtgatgc aggcccctac    840

cgctgcgtgg ccaccaactc agctcgccag cacttcagcc aggaggccct actcagtgtg    900

gcccacagag ggtccctggc gtccaccagg gggcaggacg tggtcattgt ggcagcccca    960

gagaacacca cagtggtgtc tggccagagt gtggtgatgg aatgtgtggc ctcagctgac   1020

cccacccctt ttgtgtcctg ggtccgacaa gacgggaagc ccatctccac agatgtcatc   1080

gtcctgggcc gcaccaacct actaattgcc aacgcgcagc cctggcactc cggcgtctat   1140

gtctgccgcg ccaacaagcc ccgcacgcgc gacttcgcca ctgcagccgc tgagctccgt   1200

gtgctggcgg ctcccgccat cactcaggcg cccgaggcgc tgtcgcggac gcgggcgagc   1260

acagcgcgct tcgtgtgccg cgcgtcgggg gagccgcggc cagcgctgcg ctggctgcac   1320

aacggggcgc cgctgcggcc caacgggcgc gtcaaggtcc agggcggcgg tggcagcctg   1380

gtcatcacac agatcggcct gcaggacgcc ggctactacc agtgcgtggc tgagaacagc   1440

gcgggaatgg cgtgcgctgc cgcgtcgctg gccgtggtgg tgcgcgaggg gctgcccagc   1500

gcccccacgc gggtcactgc tacgccactg agcagctccg ctgtgttggt ggcctgggag   1560

cggcccgaga tgcacagcga gcagatcatc ggcttctctc tccactacca gaaggcacgg   1620

ggcatggaca atgtggaata ccagtttgca gtgaacaacg acaccacaga actacaggtt   1680

cgggacctgg aacccaacac agattatgag ttctacgtgg tggcctactc ccagctggga   1740

gccagccgca cctccacccc agcactggtg cacacactgg atgatgtccc cagtgcagca   1800

ccccagctct ccctgtccag ccccaaccct tcggacatca gggtggcgtg gctgcccctg   1860

ccccccagcc tgagcaatgg gcaggtggtg aagtacaaga tagaatacgg tttgggaaag   1920

gaagatcaga ttttctctac tgaggtgcga ggaaatgaga cacagcttat gctgaactcg   1980

cttcagccaa acaaggtgta tcgagtacgg atttcggctg gtacagcagc cggcttcggg   2040

gccccctccc agtggatgca tcacaggacg cccagtatgc acaaccagag ccatgtccct   2100

tttgcccctg cagagttgaa ggtgcaggca aagatggagt ccctggtcgt gtcatggcag   2160

ccaccccctc accccaccca gatctctggc tacaaactat attggcggga ggtgggggct   2220

gaggaggagg ccaatggcga tcgcctgcca gggggccgtg gagaccaggc ttgggatgtg   2280

gggcctgtcc ggctcaagaa gaaagtgaag cagtatgagc tgacccagct agtccctggc   2340

cggctgtacg aggtgaagct cgtggctttc aacaaacatg aggatggcta tgcagcagtg   2400

tggaagggca agacggagaa ggcgccggca ccagacatgc ctatccagag gggaccaccc   2460

ctgcctccag cccacgtcca tgcggaatca aacagctcca catccatctg gcttcggtgg   2520

aaaaagccag atttcaccac agtcaagatt gtcaactaca ctgtgcgctt cagcccctgg   2580

gggctcagga atgcctccct ggtcacctat tacaccagtt ctggagaaga catcctcatt   2640

ggcggcttga agccattcac caaatacgag tttgcagtgc agtctcacgg cgtggacatg   2700

gatgggcctt tcggctctgt ggtggagcgc tccaccctgc ctgaccggcc ctccacaccc   2760

ccatccgacc tgcgactgag ccccctgaca ccgtccacgg ttcggctgca ctggtgcccc   2820

cccacagagc ccaacgggga gatcgtggag tatctgatcc tgtacagcag caaccacacg   2880

cagcctgagc accagtggac cttgctcacc acgcagggaa acatcttcag tgctgaggtc   2940

catggcctgg agagcgacac tcggtacttc ttcaagatgg gggcgcgcac agaggtggga   3000

cctgggcctt tctcccgcct gcaggatgtg atcacgctcc aggagaagct gtcagactcg   3060

ctggacatgc actcagtcac gggcatcatc gtgggtgtct gcctgggcct cctctgcctc   3120

ctggcctgca tgtgtgctgg cctgcgccgc agcccccaca gggaatccct cccaggcctg   3180

tcctccaccg ccacccccgg gaatcccgcg ctgtactcca gagctcggct tggccccccc   3240

agccccccag ctgcccatga attggagtcc cttgtgcacc cccatcccca ggactggtcc   3300

ccgccaccct cagacgtgga ggacagggct gaagtgcaca gccttatggg tggcggtgtt   3360

tctgaaggcc ggagtcactc caaaagaaag atctcctggg ctcaaccaag cgggctgagc   3420

tgggctggtt cctgggcagg ctgtgagctg ccccaggcag gcccccggcc ggctctgacc   3480

cgggccctgc tgccccctgc tggaactggg cagacgctgt tgctgcaggc tctggtgtac   3540

gacgccataa agggcaatgg gaggaagaag tcacccccag cctgcaggaa ccaggtggag   3600

gctgaagtca ttgtccactc tgactttagt gcatctaacg ggaaccctga cctccatctc   3660

caagacctgg agcctgagga ccccctgcct ccagaggctc ctgatctcat ctcgggtgtt   3720

ggggatccag ggcagggggc agcctggctg gacagggagt tgggagggtg tgagctggca   3780

gcccccgggc cagacagact tacctgcttg ccagaggcag ccagtgcttc ctgctcctac   3840

ccggacctcc agccaggcga ggtgctagag gagacccctg gagatagctg ccagctcaaa   3900

tccccctgcc ctctaggagc cagcccaggc ctgcccagat ccccggtctc ctcctctgcc   3960

tagctcttcc cagaggatgt ggtttggggc aggcaggtat ggatcacata ggatgcgata   4020

cctgtggccg tgtatgtcca catgtgtgcc tgtagataca tcatcaagcc ctttggagct   4080

tcctaagttg ctttggctga ggggagagga aaacatggat tattcactcc ccccatactc   4140

tttgtgatac acatgtgaca tgtgaaagac atacgagaca tagctacatg tgatgtgcac   4200

atgtgtgaag tgcatgtatg cgtactggtt gttgagctgg gaaaccgtgg cccaggcagt   4260

ggtcactaca gcctgattgg tcctccaggt cagaacggtg ccccacagtg gtcagtcccc   4320

agccctgtgg gcccccacct ccatcgccca gccttttatt acacactctg agagtgtctc   4380

caatgcctgt ctgacaaaga cagtcccagc ccattctcct gtctggctgg gttgggtgca   4440

agcaggctct gaatgcctgg catttcagct gcatcacctc ccagctcctt attgcccaaa   4500

tagagagggt ggccctggct cccctccgag caactctgca tttaattttg taatctggga   4560

agtgcctggt tttgaaaatc cgctttctct cactcttccc ctccttcctt gcccctggct   4620

gctctagtgt tctgtctccc agtcacctcg ctctcccagc accagtgccc ttctcctgct   4680

cccagatact ctttcctttc ctctctcctg ttttccttcc tctgctatct ctcacacctc   4740

tcccagacta tgtcatcttg ttctcctgcc tgggttcaaa ctctgcatcc ttctctaaca   4800

acgtgactac ctcatgtctg cttcaaggcc cccgtgccct tcctgtatcc gcggctgccg   4860

cgcactcgcc tgccatcctc ctgcctcctc ttcactcagt gcttctgctt gccctgcccc   4920

aggcagccca cccacgccca gtgcgggtgt ggagaagatc ttctggcttc cctgcatctt   4980

gcctttggga ttgggatcca agggttctcc atggatggat ccaagtcata gaggggaatg   5040

tttgagacag ggaagggggc tgtgatccag aggctcagaa taaaaagatg ccctcccttc   5100

tatgcagggg ggcaagttta ctggatggag atgatttggg cctctcttcc agaagaagct   5160

aaaggaagag aaggggagtg agagttcagg gaggcccttc ccaccctgtg aggcttgact   5220

tgatctggat tggggatgac aggaatctca ccctctgggg tgctggcaag gaggtctttg   5280

cacaggaaaa ggggtagctc atttcagttt gttttttctt taaattgaat cctcaagtca   5340

ttttctgttc acctgccgca cagggacaag cttgacttct attttctgtg tagtgaaaac   5400

aatgtcattt atttggtttt tcacctcagc cctctcatag gagcatagaa tgttagggtc   5460

tttactccct aatgatgtct gattggcaca tcaagagtta actctgcctt ctgggccaaa   5520

ttcgaaataa ccagtccatt tttccttttt tttttttttt tttttaaatg gtggaatgtc   5580

tctcagcaca gttgcggctt cctcaaaccc tgaaagcatc tgtgtttatt atactcgggt   5640

gtcactcact gttgatgtct gcacctacgt ttccacctcc tccccctcct tcagccagcc   5700

tatgataaca ctaaagatta ttaatgttgg ttttgtatct cgttaaagac agaattgtca   5760

cttgtagtat ttctgtagca ttcagcgctg ctgtggctaa caccactgtg tatgtttcat   5820

cattgctctg aaggtcaaaa gcctcatttt attttgctgg tttgattttt tttttttaaa   5880

gaagaaaaaa aaactgccct gaattaaatg gctgttttaa cagtaggctc ttagcattat   5940

accacatagt catttttcat gttcttgttt aacaggcact gaggttctgg tttaaattaa   6000

atagctgcaa atgagacaat ttataaccca ttaggttggg tggaaaattg tttctcaaaa   6060

gcaaataagt aataaatctg gtatctgcct ataactcaca gttgataaga aagtggccat   6120

ttctcactag cactatatat gatttgggct ctgggtaatt tggaagtgtt aggtttgtgt   6180

ctttgtagca gtatttttat tagaaaagaa tctattggcc ttttacaggg tattaatccc   6240

tttgtcacct accattgatg ccttaagttt tctgagtctc aattaaaaat cttccttttc   6300

ttgatgcatg acaagtgtaa tcagtacttg ctcatttatt tgtctgtatt tagtttatgc   6360

tgtactattt aattatcctt ccagcgtttt ttttttctcc ttacaaatat gatactcttt   6420

agtgttaagc taaggcattg attcatgtat ctgtccttat aatgaattaa taaactattt   6480

tccag                                                               6485


<210>  3295
<211>  1250
<212>  PRT
<213>  Homosapiens

<400>  3295

Met Ala Arg Gly Asp Ala Gly Arg Gly Arg Gly Leu Leu Ala Leu Thr 
1               5                   10                  15      


Phe Cys Leu Leu Ala Ala Arg Gly Glu Leu Leu Leu Pro Gln Glu Thr 
            20                  25                  30          


Thr Val Glu Leu Ser Cys Gly Val Gly Pro Leu Gln Val Ile Leu Gly 
        35                  40                  45              


Pro Glu Gln Ala Ala Val Leu Asn Cys Ser Leu Gly Ala Ala Ala Ala 
    50                  55                  60                  


Gly Pro Pro Thr Arg Val Thr Trp Ser Lys Asp Gly Asp Thr Leu Leu 
65                  70                  75                  80  


Glu His Asp His Leu His Leu Leu Pro Asn Gly Ser Leu Trp Leu Ser 
                85                  90                  95      


Gln Pro Leu Ala Pro Asn Gly Ser Asp Glu Ser Val Pro Glu Ala Val 
            100                 105                 110         


Gly Val Ile Glu Gly Asn Tyr Ser Cys Leu Ala His Gly Pro Leu Gly 
        115                 120                 125             


Val Leu Ala Ser Gln Thr Ala Val Val Lys Leu Ala Thr Leu Ala Asp 
    130                 135                 140                 


Phe Ser Leu His Pro Glu Ser Gln Thr Val Glu Glu Asn Gly Thr Ala 
145                 150                 155                 160 


Arg Phe Glu Cys His Ile Glu Gly Leu Pro Ala Pro Ile Ile Thr Trp 
                165                 170                 175     


Glu Lys Asp Gln Val Thr Leu Pro Glu Glu Pro Arg Leu Ile Val Leu 
            180                 185                 190         


Pro Asn Gly Val Leu Gln Ile Leu Asp Val Gln Glu Ser Asp Ala Gly 
        195                 200                 205             


Pro Tyr Arg Cys Val Ala Thr Asn Ser Ala Arg Gln His Phe Ser Gln 
    210                 215                 220                 


Glu Ala Leu Leu Ser Val Ala His Arg Gly Ser Leu Ala Ser Thr Arg 
225                 230                 235                 240 


Gly Gln Asp Val Val Ile Val Ala Ala Pro Glu Asn Thr Thr Val Val 
                245                 250                 255     


Ser Gly Gln Ser Val Val Met Glu Cys Val Ala Ser Ala Asp Pro Thr 
            260                 265                 270         


Pro Phe Val Ser Trp Val Arg Gln Asp Gly Lys Pro Ile Ser Thr Asp 
        275                 280                 285             


Val Ile Val Leu Gly Arg Thr Asn Leu Leu Ile Ala Asn Ala Gln Pro 
    290                 295                 300                 


Trp His Ser Gly Val Tyr Val Cys Arg Ala Asn Lys Pro Arg Thr Arg 
305                 310                 315                 320 


Asp Phe Ala Thr Ala Ala Ala Glu Leu Arg Val Leu Ala Ala Pro Ala 
                325                 330                 335     


Ile Thr Gln Ala Pro Glu Ala Leu Ser Arg Thr Arg Ala Ser Thr Ala 
            340                 345                 350         


Arg Phe Val Cys Arg Ala Ser Gly Glu Pro Arg Pro Ala Leu Arg Trp 
        355                 360                 365             


Leu His Asn Gly Ala Pro Leu Arg Pro Asn Gly Arg Val Lys Val Gln 
    370                 375                 380                 


Gly Gly Gly Gly Ser Leu Val Ile Thr Gln Ile Gly Leu Gln Asp Ala 
385                 390                 395                 400 


Gly Tyr Tyr Gln Cys Val Ala Glu Asn Ser Ala Gly Met Ala Cys Ala 
                405                 410                 415     


Ala Ala Ser Leu Ala Val Val Val Arg Glu Gly Leu Pro Ser Ala Pro 
            420                 425                 430         


Thr Arg Val Thr Ala Thr Pro Leu Ser Ser Ser Ala Val Leu Val Ala 
        435                 440                 445             


Trp Glu Arg Pro Glu Met His Ser Glu Gln Ile Ile Gly Phe Ser Leu 
    450                 455                 460                 


His Tyr Gln Lys Ala Arg Gly Met Asp Asn Val Glu Tyr Gln Phe Ala 
465                 470                 475                 480 


Val Asn Asn Asp Thr Thr Glu Leu Gln Val Arg Asp Leu Glu Pro Asn 
                485                 490                 495     


Thr Asp Tyr Glu Phe Tyr Val Val Ala Tyr Ser Gln Leu Gly Ala Ser 
            500                 505                 510         


Arg Thr Ser Thr Pro Ala Leu Val His Thr Leu Asp Asp Val Pro Ser 
        515                 520                 525             


Ala Ala Pro Gln Leu Ser Leu Ser Ser Pro Asn Pro Ser Asp Ile Arg 
    530                 535                 540                 


Val Ala Trp Leu Pro Leu Pro Pro Ser Leu Ser Asn Gly Gln Val Val 
545                 550                 555                 560 


Lys Tyr Lys Ile Glu Tyr Gly Leu Gly Lys Glu Asp Gln Ile Phe Ser 
                565                 570                 575     


Thr Glu Val Arg Gly Asn Glu Thr Gln Leu Met Leu Asn Ser Leu Gln 
            580                 585                 590         


Pro Asn Lys Val Tyr Arg Val Arg Ile Ser Ala Gly Thr Ala Ala Gly 
        595                 600                 605             


Phe Gly Ala Pro Ser Gln Trp Met His His Arg Thr Pro Ser Met His 
    610                 615                 620                 


Asn Gln Ser His Val Pro Phe Ala Pro Ala Glu Leu Lys Val Gln Ala 
625                 630                 635                 640 


Lys Met Glu Ser Leu Val Val Ser Trp Gln Pro Pro Pro His Pro Thr 
                645                 650                 655     


Gln Ile Ser Gly Tyr Lys Leu Tyr Trp Arg Glu Val Gly Ala Glu Glu 
            660                 665                 670         


Glu Ala Asn Gly Asp Arg Leu Pro Gly Gly Arg Gly Asp Gln Ala Trp 
        675                 680                 685             


Asp Val Gly Pro Val Arg Leu Lys Lys Lys Val Lys Gln Tyr Glu Leu 
    690                 695                 700                 


Thr Gln Leu Val Pro Gly Arg Leu Tyr Glu Val Lys Leu Val Ala Phe 
705                 710                 715                 720 


Asn Lys His Glu Asp Gly Tyr Ala Ala Val Trp Lys Gly Lys Thr Glu 
                725                 730                 735     


Lys Ala Pro Ala Pro Asp Met Pro Ile Gln Arg Gly Pro Pro Leu Pro 
            740                 745                 750         


Pro Ala His Val His Ala Glu Ser Asn Ser Ser Thr Ser Ile Trp Leu 
        755                 760                 765             


Arg Trp Lys Lys Pro Asp Phe Thr Thr Val Lys Ile Val Asn Tyr Thr 
    770                 775                 780                 


Val Arg Phe Ser Pro Trp Gly Leu Arg Asn Ala Ser Leu Val Thr Tyr 
785                 790                 795                 800 


Tyr Thr Ser Ser Gly Glu Asp Ile Leu Ile Gly Gly Leu Lys Pro Phe 
                805                 810                 815     


Thr Lys Tyr Glu Phe Ala Val Gln Ser His Gly Val Asp Met Asp Gly 
            820                 825                 830         


Pro Phe Gly Ser Val Val Glu Arg Ser Thr Leu Pro Asp Arg Pro Ser 
        835                 840                 845             


Thr Pro Pro Ser Asp Leu Arg Leu Ser Pro Leu Thr Pro Ser Thr Val 
    850                 855                 860                 


Arg Leu His Trp Cys Pro Pro Thr Glu Pro Asn Gly Glu Ile Val Glu 
865                 870                 875                 880 


Tyr Leu Ile Leu Tyr Ser Ser Asn His Thr Gln Pro Glu His Gln Trp 
                885                 890                 895     


Thr Leu Leu Thr Thr Gln Gly Asn Ile Phe Ser Ala Glu Val His Gly 
            900                 905                 910         


Leu Glu Ser Asp Thr Arg Tyr Phe Phe Lys Met Gly Ala Arg Thr Glu 
        915                 920                 925             


Val Gly Pro Gly Pro Phe Ser Arg Leu Gln Asp Val Ile Thr Leu Gln 
    930                 935                 940                 


Glu Lys Leu Ser Asp Ser Leu Asp Met His Ser Val Thr Gly Ile Ile 
945                 950                 955                 960 


Val Gly Val Cys Leu Gly Leu Leu Cys Leu Leu Ala Cys Met Cys Ala 
                965                 970                 975     


Gly Leu Arg Arg Ser Pro His Arg Glu Ser Leu Pro Gly Leu Ser Ser 
            980                 985                 990         


Thr Ala Thr Pro Gly Asn Pro Ala  Leu Tyr Ser Arg Ala  Arg Leu Gly 
        995                 1000                 1005             


Pro Pro  Ser Pro Pro Ala Ala  His Glu Leu Glu Ser  Leu Val His 
    1010                 1015                 1020             


Pro His  Pro Gln Asp Trp Ser  Pro Pro Pro Ser Asp  Val Glu Asp 
    1025                 1030                 1035             


Arg Ala  Glu Val His Ser Leu  Met Gly Gly Gly Val  Ser Glu Gly 
    1040                 1045                 1050             


Arg Ser  His Ser Lys Arg Lys  Ile Ser Trp Ala Gln  Pro Ser Gly 
    1055                 1060                 1065             


Leu Ser  Trp Ala Gly Ser Trp  Ala Gly Cys Glu Leu  Pro Gln Ala 
    1070                 1075                 1080             


Gly Pro  Arg Pro Ala Leu Thr  Arg Ala Leu Leu Pro  Pro Ala Gly 
    1085                 1090                 1095             


Thr Gly  Gln Thr Leu Leu Leu  Gln Ala Leu Val Tyr  Asp Ala Ile 
    1100                 1105                 1110             


Lys Gly  Asn Gly Arg Lys Lys  Ser Pro Pro Ala Cys  Arg Asn Gln 
    1115                 1120                 1125             


Val Glu  Ala Glu Val Ile Val  His Ser Asp Phe Ser  Ala Ser Asn 
    1130                 1135                 1140             


Gly Asn  Pro Asp Leu His Leu  Gln Asp Leu Glu Pro  Glu Asp Pro 
    1145                 1150                 1155             


Leu Pro  Pro Glu Ala Pro Asp  Leu Ile Ser Gly Val  Gly Asp Pro 
    1160                 1165                 1170             


Gly Gln  Gly Ala Ala Trp Leu  Asp Arg Glu Leu Gly  Gly Cys Glu 
    1175                 1180                 1185             


Leu Ala  Ala Pro Gly Pro Asp  Arg Leu Thr Cys Leu  Pro Glu Ala 
    1190                 1195                 1200             


Ala Ser  Ala Ser Cys Ser Tyr  Pro Asp Leu Gln Pro  Gly Glu Val 
    1205                 1210                 1215             


Leu Glu  Glu Thr Pro Gly Asp  Ser Cys Gln Leu Lys  Ser Pro Cys 
    1220                 1225                 1230             


Pro Leu  Gly Ala Ser Pro Gly  Leu Pro Arg Ser Pro  Val Ser Ser 
    1235                 1240                 1245             


Ser Ala  
    1250 


<210>  3296
<211>  3796
<212>  DNA
<213>  Homosapiens

<400>  3296
aacgaaccgg aagtgctaaa gcctccgagg ccaaggccgc tgctactgcc gccgctgctt     60

cttagtgccg cgttcgccgc ctgggttgtc accggcgccg ccgccgagga agccactgca    120

accaggaccg gagtggaggc ggcgcagcat gaagcggcgc aggcccgctc catagcgcac    180

gtcgggacgg tccgggcggg gccgggggga aggaaaatgc aacatggcag cagcaatgga    240

aacagaacag ctgggtgttg agatatttga aactgcggac tgtgaggaga atattgaatc    300

acaggatcgg cctaaattgg agccttttta tgttgagcgg tattcctgga gtcagcttaa    360

aaagctgctt gccgatacca gaaaatatca tggctacatg atggctaagg caccacatga    420

tttcatgttt gtgaagagga atgatccaga tggacctcat tcagacagaa tctattacct    480

tgccatgtct ggtgagaaca gagaaaatac actgttttat tctgaaattc ccaaaactat    540

caatagagca gcagtcttaa tgctctcttg gaagcctctt ttggatcttt ttcaggcaac    600

actggactat ggaatgtatt ctcgagaaga agaactatta agagaaagaa aacgcattgg    660

aacagtcgga attgcttctt acgattatca ccaaggaagt ggaacatttc tgtttcaagc    720

cggtagtgga atttatcacg taaaagatgg agggccacaa ggatttacgc aacaaccttt    780

aaggcccaat ctagtggaaa ctagttgtcc caacatacgg atggatccaa aattatgccc    840

tgctgatcca gactggattg cttttataca tagcaacgat atttggatat ctaacatcgt    900

aaccagagaa gaaaggagac tcacttatgt gcacaatgag ctagccaaca tggaagaaga    960

tgccagatca gctggagtcg ctacctttgt tctccaagaa gaatttgata gatattctgg   1020

ctattggtgg tgtccaaaag ctgaaacaac tcccagtggt ggtaaaattc ttagaattct   1080

atatgaagaa aatgatgaat ctgaggtgga aattattcat gttacatccc ctatgttgga   1140

aacaaggagg gcagattcat tccgttatcc taaaacaggt acagcaaatc ctaaagtcac   1200

ttttaagatg tcagaaataa tgattgatgc tgaaggaagg atcatagatg tcatagataa   1260

ggaactaatt caaccttttg agattctatt tgaaggagtt gaatatattg ccagagctgg   1320

atggactcct gagggaaaat atgcttggtc catcctacta gatcgctccc agactcgcct   1380

acagatagtg ttgatctcac ctgaattatt tatcccagta gaagatgatg ttatggaaag   1440

gcagagactc attgagtcag tgcctgattc tgtgacgcca ctaattatct atgaagaaac   1500

aacagacatc tggataaata tccatgacat ctttcatgtt tttccccaaa gtcacgaaga   1560

ggaaattgag tttatttttg cctctgaatg caaaacaggt ttccgtcatt tatacaaaat   1620

tacatctatt ttaaaggaaa gcaaatataa acgatccagt ggtgggctgc ctgctccaag   1680

tgatttcaag tgtcctatca aagaggagat agcaattacc agtggtgaat gggaagttct   1740

tggccggcat ggatctaata tccaagttga tgaagtcaga aggctggtat attttgaagg   1800

caccaaagac tcccctttag agcatcacct gtacgtagtc agttacgtaa atcctggaga   1860

ggtgacaagg ctgactgacc gtggctactc acattcttgc tgcatcagtc agcactgtga   1920

cttctttata agtaagtata gtaaccagaa gaatccacac tgtgtgtccc tttacaagct   1980

atcaagtcct gaagatgacc caacttgcaa aacaaaggaa ttttgggcca ccattttgga   2040

ttcagcaggt cctcttcctg actatactcc tccagaaatt ttctcttttg aaagtactac   2100

tggatttaca ttgtatggga tgctctacaa gcctcatgat ctacagcctg gaaagaaata   2160

tcctactgtg ctgttcatat atggtggtcc tcaggttgct attgctgggg ccccagtcac   2220

tctgtggatc ttctatgata caggatacac ggaacgttat atgggtcacc ctgaccagaa   2280

tgaacagggc tattacttag gatctgtggc catgcaagca gaaaagttcc cctctgaacc   2340

aaatcgttta ctgctcttac atggtttcct ggatgagaat gtccattttg cacataccag   2400

tatattactg agttttttag tgagggctgg aaagccatat gatttacaga tctatcctca   2460

ggagagacac agcataagag ttcctgaatc gggagaacat tatgaactgc atcttttgca   2520

ctaccttcaa gaaaaccttg gatcacgtat tgctgctcta aaagtgatat aattttgacc   2580

tgtgtagaac tctctggtat acactggcta tttaaccaaa tgaggaggtt taatcaacag   2640

aaaacacaga attgatcatc acattttgat acctgccatg taacatctac tcctgaaaat   2700

aaatgtggtg ccatgcaggg gtctacggtt tgtggtagta atctaatacc ttaaccccac   2760

atgctcaaaa tcaaatgata catattcctg agagacccag caataccata agaattacta   2820

aaaaaaaaaa aaaaaaaaag acattagcac catgtattca tactacccta ttttcacttt   2880

taatagtatt ataaacttca tgaacttaat tagtgtattt ttacagtata cttttgagtt   2940

tgttaaaata tgatgatatt agtgattggt ttggttcagt tccagaatct ttgactagtt   3000

acagatttga tagcacttaa atgtaattga atagcttatg cttcattgct tgggcatatc   3060

cagcatgtta tgaactaata actattaaac ttgacttaac cagtcattca ttaataattt   3120

ttcaaggata acttagtggc ctcctaaaga cacttgtttt ggcactgacc agtttttagc   3180

caatttaatc tgtatctagt ataaataatt ctcatttttc tttgatgata ttaacagagt   3240

gggcttttcc ttttgcataa aggctagtaa ctgtatatgt agcatggatt taattagtca   3300

tgatattgat aattacaggc agaaaatttt taatcaaatg attagagctt aaatatttgc   3360

aggcaagttt ttttttttcc tttaagaaaa ggaaaaagta cacattcact agaattcttc   3420

agaaaattta gtggtgccag tttccatttg gtatttcctt attaaaatat tctagaattt   3480

taaggagatt gaagggaatc acagtggggt ggggagacct gggtttgggg aatgacagag   3540

agaagaggtg gtgagggcct gattaaaaac taagcagaag tagttttaac aaaaatactc   3600

atgaaaatgt ttggaaactg aaatttaaac aactgtaata ttaaggaaac cagaatcaat   3660

aaatcactgt cttgccagca cagctacaga gtaacatgat tcaggggagg aaaagttcct   3720

tagagttact tttataattc tttttttttt tcctcttagg tttagaaatc ttacaaattt   3780

aaactttatc ctttta                                                   3796


<210>  3297
<211>  782
<212>  PRT
<213>  Homosapiens

<400>  3297

Met Ala Ala Ala Met Glu Thr Glu Gln Leu Gly Val Glu Ile Phe Glu 
1               5                   10                  15      


Thr Ala Asp Cys Glu Glu Asn Ile Glu Ser Gln Asp Arg Pro Lys Leu 
            20                  25                  30          


Glu Pro Phe Tyr Val Glu Arg Tyr Ser Trp Ser Gln Leu Lys Lys Leu 
        35                  40                  45              


Leu Ala Asp Thr Arg Lys Tyr His Gly Tyr Met Met Ala Lys Ala Pro 
    50                  55                  60                  


His Asp Phe Met Phe Val Lys Arg Asn Asp Pro Asp Gly Pro His Ser 
65                  70                  75                  80  


Asp Arg Ile Tyr Tyr Leu Ala Met Ser Gly Glu Asn Arg Glu Asn Thr 
                85                  90                  95      


Leu Phe Tyr Ser Glu Ile Pro Lys Thr Ile Asn Arg Ala Ala Val Leu 
            100                 105                 110         


Met Leu Ser Trp Lys Pro Leu Leu Asp Leu Phe Gln Ala Thr Leu Asp 
        115                 120                 125             


Tyr Gly Met Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg 
    130                 135                 140                 


Ile Gly Thr Val Gly Ile Ala Ser Tyr Asp Tyr His Gln Gly Ser Gly 
145                 150                 155                 160 


Thr Phe Leu Phe Gln Ala Gly Ser Gly Ile Tyr His Val Lys Asp Gly 
                165                 170                 175     


Gly Pro Gln Gly Phe Thr Gln Gln Pro Leu Arg Pro Asn Leu Val Glu 
            180                 185                 190         


Thr Ser Cys Pro Asn Ile Arg Met Asp Pro Lys Leu Cys Pro Ala Asp 
        195                 200                 205             


Pro Asp Trp Ile Ala Phe Ile His Ser Asn Asp Ile Trp Ile Ser Asn 
    210                 215                 220                 


Ile Val Thr Arg Glu Glu Arg Arg Leu Thr Tyr Val His Asn Glu Leu 
225                 230                 235                 240 


Ala Asn Met Glu Glu Asp Ala Arg Ser Ala Gly Val Ala Thr Phe Val 
                245                 250                 255     


Leu Gln Glu Glu Phe Asp Arg Tyr Ser Gly Tyr Trp Trp Cys Pro Lys 
            260                 265                 270         


Ala Glu Thr Thr Pro Ser Gly Gly Lys Ile Leu Arg Ile Leu Tyr Glu 
        275                 280                 285             


Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr Ser Pro Met 
    290                 295                 300                 


Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr Pro Lys Thr Gly Thr 
305                 310                 315                 320 


Ala Asn Pro Lys Val Thr Phe Lys Met Ser Glu Ile Met Ile Asp Ala 
                325                 330                 335     


Glu Gly Arg Ile Ile Asp Val Ile Asp Lys Glu Leu Ile Gln Pro Phe 
            340                 345                 350         


Glu Ile Leu Phe Glu Gly Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr 
        355                 360                 365             


Pro Glu Gly Lys Tyr Ala Trp Ser Ile Leu Leu Asp Arg Ser Gln Thr 
    370                 375                 380                 


Arg Leu Gln Ile Val Leu Ile Ser Pro Glu Leu Phe Ile Pro Val Glu 
385                 390                 395                 400 


Asp Asp Val Met Glu Arg Gln Arg Leu Ile Glu Ser Val Pro Asp Ser 
                405                 410                 415     


Val Thr Pro Leu Ile Ile Tyr Glu Glu Thr Thr Asp Ile Trp Ile Asn 
            420                 425                 430         


Ile His Asp Ile Phe His Val Phe Pro Gln Ser His Glu Glu Glu Ile 
        435                 440                 445             


Glu Phe Ile Phe Ala Ser Glu Cys Lys Thr Gly Phe Arg His Leu Tyr 
    450                 455                 460                 


Lys Ile Thr Ser Ile Leu Lys Glu Ser Lys Tyr Lys Arg Ser Ser Gly 
465                 470                 475                 480 


Gly Leu Pro Ala Pro Ser Asp Phe Lys Cys Pro Ile Lys Glu Glu Ile 
                485                 490                 495     


Ala Ile Thr Ser Gly Glu Trp Glu Val Leu Gly Arg His Gly Ser Asn 
            500                 505                 510         


Ile Gln Val Asp Glu Val Arg Arg Leu Val Tyr Phe Glu Gly Thr Lys 
        515                 520                 525             


Asp Ser Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Val Asn Pro 
    530                 535                 540                 


Gly Glu Val Thr Arg Leu Thr Asp Arg Gly Tyr Ser His Ser Cys Cys 
545                 550                 555                 560 


Ile Ser Gln His Cys Asp Phe Phe Ile Ser Lys Tyr Ser Asn Gln Lys 
                565                 570                 575     


Asn Pro His Cys Val Ser Leu Tyr Lys Leu Ser Ser Pro Glu Asp Asp 
            580                 585                 590         


Pro Thr Cys Lys Thr Lys Glu Phe Trp Ala Thr Ile Leu Asp Ser Ala 
        595                 600                 605             


Gly Pro Leu Pro Asp Tyr Thr Pro Pro Glu Ile Phe Ser Phe Glu Ser 
    610                 615                 620                 


Thr Thr Gly Phe Thr Leu Tyr Gly Met Leu Tyr Lys Pro His Asp Leu 
625                 630                 635                 640 


Gln Pro Gly Lys Lys Tyr Pro Thr Val Leu Phe Ile Tyr Gly Gly Pro 
                645                 650                 655     


Gln Val Ala Ile Ala Gly Ala Pro Val Thr Leu Trp Ile Phe Tyr Asp 
            660                 665                 670         


Thr Gly Tyr Thr Glu Arg Tyr Met Gly His Pro Asp Gln Asn Glu Gln 
        675                 680                 685             


Gly Tyr Tyr Leu Gly Ser Val Ala Met Gln Ala Glu Lys Phe Pro Ser 
    690                 695                 700                 


Glu Pro Asn Arg Leu Leu Leu Leu His Gly Phe Leu Asp Glu Asn Val 
705                 710                 715                 720 


His Phe Ala His Thr Ser Ile Leu Leu Ser Phe Leu Val Arg Ala Gly 
                725                 730                 735     


Lys Pro Tyr Asp Leu Gln Ile Tyr Pro Gln Glu Arg His Ser Ile Arg 
            740                 745                 750         


Val Pro Glu Ser Gly Glu His Tyr Glu Leu His Leu Leu His Tyr Leu 
        755                 760                 765             


Gln Glu Asn Leu Gly Ser Arg Ile Ala Ala Leu Lys Val Ile 
    770                 775                 780         


<210>  3298
<211>  4096
<212>  DNA
<213>  Homosapiens

<400>  3298
aacgaaccgg aagtgctaaa gcctccgagg ccaaggccgc tgctactgcc gccgctgctt     60

cttagtgccg cgttcgccgc ctgggttgtc accggcgccg ccgccgagga agccactgca    120

accaggaccg gagtggaggc ggcgcagcat gaagcggcgc aggcccgctc catagcgcac    180

gtcgggacgg tccgggcggg gccgggggga aggaaaatgc aacatggcag cagcaatgga    240

aacagaacag ctgggtgttg agatatttga aactgcggac tgtgaggaga atattgaatc    300

acaggatcgg cctaaattgg agccttttta tgttgagcgg tattcctgga gtcagcttaa    360

aaagctgctt gccgatacca gaaaatatca tggctacatg atggctaagg caccacatga    420

tttcatgttt gtgaagagga atgatccaga tggacctcat tcagacagaa tctattacct    480

tgccatgtct ggtgagaaca gagaaaatac actgttttat tctgaaattc ccaaaactat    540

caatagagca gcagtcttaa tgctctcttg gaagcctctt ttggatcttt ttcaggcaac    600

actggactat ggaatgtatt ctcgagaaga agaactatta agagaaagaa aacgcattgg    660

aacagtcgga attgcttctt acgattatca ccaaggaagt ggaacatttc tgtttcaagc    720

cggtagtgga atttatcacg taaaagatgg agggccacaa ggatttacgc aacaaccttt    780

aaggcccaat ctagtggaaa ctagttgtcc caacatacgg atggatccaa aattatgccc    840

tgctgatcca gactggattg cttttataca tagcaacgat atttggatat ctaacatcgt    900

aaccagagaa gaaaggagac tcacttatgt gcacaatgag ctagccaaca tggaagaaga    960

tgccagatca gctggagtcg ctacctttgt tctccaagaa gaatttgata gatattctgg   1020

ctattggtgg tgtccaaaag ctgaaacaac tcccagtggt ggtaaaattc ttagaattct   1080

atatgaagaa aatgatgaat ctgaggtgga aattattcat gttacatccc ctatgttgga   1140

aacaaggagg gcagattcat tccgttatcc taaaacaggt acagcaaatc ctaaagtcac   1200

ttttaagatg tcagaaataa tgattgatgc tgaaggaagg atcatagatg tcatagataa   1260

ggaactaatt caaccttttg agattctatt tgaaggagtt gaatatattg ccagagctgg   1320

atggactcct gagggaaaat atgcttggtc catcctacta gatcgctccc agactcgcct   1380

acagatagtg ttgatctcac ctgaattatt tatcccagta gaagatgatg ttatggaaag   1440

gcagagactc attgagtcag tgcctgattc tgtgacgcca ctaattatct atgaagaaac   1500

aacagacatc tggataaata tccatgacat ctttcatgtt tttccccaaa gtcacgaaga   1560

ggaaattgag tttatttttg cctctgaatg caaaacaggt ttccgtcatt tatacaaaat   1620

tacatctatt ttaaaggaaa gcaaatataa acgatccagt ggtgggctgc ctgctccaag   1680

tgatttcaag tgtcctatca aagaggagat agcaattacc agtggtgaat gggaagttct   1740

tggccggcat ggatctaata tccaagttga tgaagtcaga aggctggtat attttgaagg   1800

caccaaagac tcccctttag agcatcacct gtacgtagtc agttacgtaa atcctggaga   1860

ggtgacaagg ctgactgacc gtggctactc acattcttgc tgcatcagtc agcactgtga   1920

cttctttata agtaagtata gtaaccagaa gaatccacac tgtgtgtccc tttacaagct   1980

atcaagtcct gaagatgacc caacttgcaa aacaaaggaa ttttgggcca ccattttgga   2040

ttcagcaggt cctcttcctg actatactcc tccagaaatt ttctcttttg aaagtactac   2100

tggatttaca ttgtatggga tgctctacaa gcctcatgat ctacagcctg gaaagaaata   2160

tcctactgtg ctgttcatat atggtggtcc tcaggtgcag ttggtgaata atcggtttaa   2220

aggagtcaag tatttccgct tgaataccct agcctctcta ggttatgtgg ttgtagtgat   2280

agacaacagg ggatcctgtc accgagggct taaatttgaa ggcgccttta aatataaaat   2340

gggtcaaata gaaattgacg atcaggtgga aggactccaa tatctagctt ctcgatatga   2400

tttcattgac ttagatcgtg tgggcatcca cggctggtcc tatggaggat acctctccct   2460

gatggcatta atgcagaggt cagatatctt cagggttgct attgctgggg ccccagtcac   2520

tctgtggatc ttctatgata caggatacac ggaacgttat atgggtcacc ctgaccagaa   2580

tgaacagggc tattacttag gatctgtggc catgcaagca gaaaagttcc cctctgaacc   2640

aaatcgttta ctgctcttac atggtttcct ggatgagaat gtccattttg cacataccag   2700

tatattactg agttttttag tgagggctgg aaagccatat gatttacaga tctatcctca   2760

ggagagacac agcataagag ttcctgaatc gggagaacat tatgaactgc atcttttgca   2820

ctaccttcaa gaaaaccttg gatcacgtat tgctgctcta aaagtgatat aattttgacc   2880

tgtgtagaac tctctggtat acactggcta tttaaccaaa tgaggaggtt taatcaacag   2940

aaaacacaga attgatcatc acattttgat acctgccatg taacatctac tcctgaaaat   3000

aaatgtggtg ccatgcaggg gtctacggtt tgtggtagta atctaatacc ttaaccccac   3060

atgctcaaaa tcaaatgata catattcctg agagacccag caataccata agaattacta   3120

aaaaaaaaaa aaaaaaaaag acattagcac catgtattca tactacccta ttttcacttt   3180

taatagtatt ataaacttca tgaacttaat tagtgtattt ttacagtata cttttgagtt   3240

tgttaaaata tgatgatatt agtgattggt ttggttcagt tccagaatct ttgactagtt   3300

acagatttga tagcacttaa atgtaattga atagcttatg cttcattgct tgggcatatc   3360

cagcatgtta tgaactaata actattaaac ttgacttaac cagtcattca ttaataattt   3420

ttcaaggata acttagtggc ctcctaaaga cacttgtttt ggcactgacc agtttttagc   3480

caatttaatc tgtatctagt ataaataatt ctcatttttc tttgatgata ttaacagagt   3540

gggcttttcc ttttgcataa aggctagtaa ctgtatatgt agcatggatt taattagtca   3600

tgatattgat aattacaggc agaaaatttt taatcaaatg attagagctt aaatatttgc   3660

aggcaagttt ttttttttcc tttaagaaaa ggaaaaagta cacattcact agaattcttc   3720

agaaaattta gtggtgccag tttccatttg gtatttcctt attaaaatat tctagaattt   3780

taaggagatt gaagggaatc acagtggggt ggggagacct gggtttgggg aatgacagag   3840

agaagaggtg gtgagggcct gattaaaaac taagcagaag tagttttaac aaaaatactc   3900

atgaaaatgt ttggaaactg aaatttaaac aactgtaata ttaaggaaac cagaatcaat   3960

aaatcactgt cttgccagca cagctacaga gtaacatgat tcaggggagg aaaagttcct   4020

tagagttact tttataattc tttttttttt tcctcttagg tttagaaatc ttacaaattt   4080

aaactttatc ctttta                                                   4096


<210>  3299
<211>  882
<212>  PRT
<213>  Homosapiens

<400>  3299

Met Ala Ala Ala Met Glu Thr Glu Gln Leu Gly Val Glu Ile Phe Glu 
1               5                   10                  15      


Thr Ala Asp Cys Glu Glu Asn Ile Glu Ser Gln Asp Arg Pro Lys Leu 
            20                  25                  30          


Glu Pro Phe Tyr Val Glu Arg Tyr Ser Trp Ser Gln Leu Lys Lys Leu 
        35                  40                  45              


Leu Ala Asp Thr Arg Lys Tyr His Gly Tyr Met Met Ala Lys Ala Pro 
    50                  55                  60                  


His Asp Phe Met Phe Val Lys Arg Asn Asp Pro Asp Gly Pro His Ser 
65                  70                  75                  80  


Asp Arg Ile Tyr Tyr Leu Ala Met Ser Gly Glu Asn Arg Glu Asn Thr 
                85                  90                  95      


Leu Phe Tyr Ser Glu Ile Pro Lys Thr Ile Asn Arg Ala Ala Val Leu 
            100                 105                 110         


Met Leu Ser Trp Lys Pro Leu Leu Asp Leu Phe Gln Ala Thr Leu Asp 
        115                 120                 125             


Tyr Gly Met Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg 
    130                 135                 140                 


Ile Gly Thr Val Gly Ile Ala Ser Tyr Asp Tyr His Gln Gly Ser Gly 
145                 150                 155                 160 


Thr Phe Leu Phe Gln Ala Gly Ser Gly Ile Tyr His Val Lys Asp Gly 
                165                 170                 175     


Gly Pro Gln Gly Phe Thr Gln Gln Pro Leu Arg Pro Asn Leu Val Glu 
            180                 185                 190         


Thr Ser Cys Pro Asn Ile Arg Met Asp Pro Lys Leu Cys Pro Ala Asp 
        195                 200                 205             


Pro Asp Trp Ile Ala Phe Ile His Ser Asn Asp Ile Trp Ile Ser Asn 
    210                 215                 220                 


Ile Val Thr Arg Glu Glu Arg Arg Leu Thr Tyr Val His Asn Glu Leu 
225                 230                 235                 240 


Ala Asn Met Glu Glu Asp Ala Arg Ser Ala Gly Val Ala Thr Phe Val 
                245                 250                 255     


Leu Gln Glu Glu Phe Asp Arg Tyr Ser Gly Tyr Trp Trp Cys Pro Lys 
            260                 265                 270         


Ala Glu Thr Thr Pro Ser Gly Gly Lys Ile Leu Arg Ile Leu Tyr Glu 
        275                 280                 285             


Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr Ser Pro Met 
    290                 295                 300                 


Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr Pro Lys Thr Gly Thr 
305                 310                 315                 320 


Ala Asn Pro Lys Val Thr Phe Lys Met Ser Glu Ile Met Ile Asp Ala 
                325                 330                 335     


Glu Gly Arg Ile Ile Asp Val Ile Asp Lys Glu Leu Ile Gln Pro Phe 
            340                 345                 350         


Glu Ile Leu Phe Glu Gly Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr 
        355                 360                 365             


Pro Glu Gly Lys Tyr Ala Trp Ser Ile Leu Leu Asp Arg Ser Gln Thr 
    370                 375                 380                 


Arg Leu Gln Ile Val Leu Ile Ser Pro Glu Leu Phe Ile Pro Val Glu 
385                 390                 395                 400 


Asp Asp Val Met Glu Arg Gln Arg Leu Ile Glu Ser Val Pro Asp Ser 
                405                 410                 415     


Val Thr Pro Leu Ile Ile Tyr Glu Glu Thr Thr Asp Ile Trp Ile Asn 
            420                 425                 430         


Ile His Asp Ile Phe His Val Phe Pro Gln Ser His Glu Glu Glu Ile 
        435                 440                 445             


Glu Phe Ile Phe Ala Ser Glu Cys Lys Thr Gly Phe Arg His Leu Tyr 
    450                 455                 460                 


Lys Ile Thr Ser Ile Leu Lys Glu Ser Lys Tyr Lys Arg Ser Ser Gly 
465                 470                 475                 480 


Gly Leu Pro Ala Pro Ser Asp Phe Lys Cys Pro Ile Lys Glu Glu Ile 
                485                 490                 495     


Ala Ile Thr Ser Gly Glu Trp Glu Val Leu Gly Arg His Gly Ser Asn 
            500                 505                 510         


Ile Gln Val Asp Glu Val Arg Arg Leu Val Tyr Phe Glu Gly Thr Lys 
        515                 520                 525             


Asp Ser Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Val Asn Pro 
    530                 535                 540                 


Gly Glu Val Thr Arg Leu Thr Asp Arg Gly Tyr Ser His Ser Cys Cys 
545                 550                 555                 560 


Ile Ser Gln His Cys Asp Phe Phe Ile Ser Lys Tyr Ser Asn Gln Lys 
                565                 570                 575     


Asn Pro His Cys Val Ser Leu Tyr Lys Leu Ser Ser Pro Glu Asp Asp 
            580                 585                 590         


Pro Thr Cys Lys Thr Lys Glu Phe Trp Ala Thr Ile Leu Asp Ser Ala 
        595                 600                 605             


Gly Pro Leu Pro Asp Tyr Thr Pro Pro Glu Ile Phe Ser Phe Glu Ser 
    610                 615                 620                 


Thr Thr Gly Phe Thr Leu Tyr Gly Met Leu Tyr Lys Pro His Asp Leu 
625                 630                 635                 640 


Gln Pro Gly Lys Lys Tyr Pro Thr Val Leu Phe Ile Tyr Gly Gly Pro 
                645                 650                 655     


Gln Val Gln Leu Val Asn Asn Arg Phe Lys Gly Val Lys Tyr Phe Arg 
            660                 665                 670         


Leu Asn Thr Leu Ala Ser Leu Gly Tyr Val Val Val Val Ile Asp Asn 
        675                 680                 685             


Arg Gly Ser Cys His Arg Gly Leu Lys Phe Glu Gly Ala Phe Lys Tyr 
    690                 695                 700                 


Lys Met Gly Gln Ile Glu Ile Asp Asp Gln Val Glu Gly Leu Gln Tyr 
705                 710                 715                 720 


Leu Ala Ser Arg Tyr Asp Phe Ile Asp Leu Asp Arg Val Gly Ile His 
                725                 730                 735     


Gly Trp Ser Tyr Gly Gly Tyr Leu Ser Leu Met Ala Leu Met Gln Arg 
            740                 745                 750         


Ser Asp Ile Phe Arg Val Ala Ile Ala Gly Ala Pro Val Thr Leu Trp 
        755                 760                 765             


Ile Phe Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met Gly His Pro Asp 
    770                 775                 780                 


Gln Asn Glu Gln Gly Tyr Tyr Leu Gly Ser Val Ala Met Gln Ala Glu 
785                 790                 795                 800 


Lys Phe Pro Ser Glu Pro Asn Arg Leu Leu Leu Leu His Gly Phe Leu 
                805                 810                 815     


Asp Glu Asn Val His Phe Ala His Thr Ser Ile Leu Leu Ser Phe Leu 
            820                 825                 830         


Val Arg Ala Gly Lys Pro Tyr Asp Leu Gln Ile Tyr Pro Gln Glu Arg 
        835                 840                 845             


His Ser Ile Arg Val Pro Glu Ser Gly Glu His Tyr Glu Leu His Leu 
    850                 855                 860                 


Leu His Tyr Leu Gln Glu Asn Leu Gly Ser Arg Ile Ala Ala Leu Lys 
865                 870                 875                 880 


Val Ile 
        


<210>  3300
<211>  4086
<212>  DNA
<213>  Homosapiens

<400>  3300
attccgagtc aaccaccgtt cactgggcgc cccttgagct ctgggcgctg gcctcctggc     60

ttccacgctt tgatggtgag gaaaggaaag attcctgtga gaagagcagg atgagcagag    120

ggattctatg cttgaagtcg agtcacttga aaaagatctc tttgaatgtg gaagagatct    180

gagcagatga aaataaaatc aggaaaatgc aacatggcag cagcaatgga aacagaacag    240

ctgggtgttg agatatttga aactgcggac tgtgaggaga atattgaatc acaggatcgg    300

cctaaattgg agccttttta tgttgagcgg tattcctgga gtcagcttaa aaagctgctt    360

gccgatacca gaaaatatca tggctacatg atggctaagg caccacatga tttcatgttt    420

gtgaagagga atgatccaga tggacctcat tcagacagaa tctattacct tgccatgtct    480

ggtgagaaca gagaaaatac actgttttat tctgaaattc ccaaaactat caatagagca    540

gcagtcttaa tgctctcttg gaagcctctt ttggatcttt ttcaggcaac actggactat    600

ggaatgtatt ctcgagaaga agaactatta agagaaagaa aacgcattgg aacagtcgga    660

attgcttctt acgattatca ccaaggaagt ggaacatttc tgtttcaagc cggtagtgga    720

atttatcacg taaaagatgg agggccacaa ggatttacgc aacaaccttt aaggcccaat    780

ctagtggaaa ctagttgtcc caacatacgg atggatccaa aattatgccc tgctgatcca    840

gactggattg cttttataca tagcaacgat atttggatat ctaacatcgt aaccagagaa    900

gaaaggagac tcacttatgt gcacaatgag ctagccaaca tggaagaaga tgccagatca    960

gctggagtcg ctacctttgt tctccaagaa gaatttgata gatattctgg ctattggtgg   1020

tgtccaaaag ctgaaacaac tcccagtggt ggtaaaattc ttagaattct atatgaagaa   1080

aatgatgaat ctgaggtgga aattattcat gttacatccc ctatgttgga aacaaggagg   1140

gcagattcat tccgttatcc taaaacaggt acagcaaatc ctaaagtcac ttttaagatg   1200

tcagaaataa tgattgatgc tgaaggaagg atcatagatg tcatagataa ggaactaatt   1260

caaccttttg agattctatt tgaaggagtt gaatatattg ccagagctgg atggactcct   1320

gagggaaaat atgcttggtc catcctacta gatcgctccc agactcgcct acagatagtg   1380

ttgatctcac ctgaattatt tatcccagta gaagatgatg ttatggaaag gcagagactc   1440

attgagtcag tgcctgattc tgtgacgcca ctaattatct atgaagaaac aacagacatc   1500

tggataaata tccatgacat ctttcatgtt tttccccaaa gtcacgaaga ggaaattgag   1560

tttatttttg cctctgaatg caaaacaggt ttccgtcatt tatacaaaat tacatctatt   1620

ttaaaggaaa gcaaatataa acgatccagt ggtgggctgc ctgctccaag tgatttcaag   1680

tgtcctatca aagaggagat agcaattacc agtggtgaat gggaagttct tggccggcat   1740

ggatctaata tccaagttga tgaagtcaga aggctggtat attttgaagg caccaaagac   1800

tcccctttag agcatcacct gtacgtagtc agttacgtaa atcctggaga ggtgacaagg   1860

ctgactgacc gtggctactc acattcttgc tgcatcagtc agcactgtga cttctttata   1920

agtaagtata gtaaccagaa gaatccacac tgtgtgtccc tttacaagct atcaagtcct   1980

gaagatgacc caacttgcaa aacaaaggaa ttttgggcca ccattttgga ttcagcaggt   2040

cctcttcctg actatactcc tccagaaatt ttctcttttg aaagtactac tggatttaca   2100

ttgtatggga tgctctacaa gcctcatgat ctacagcctg gaaagaaata tcctactgtg   2160

ctgttcatat atggtggtcc tcaggtgcag ttggtgaata atcggtttaa aggagtcaag   2220

tatttccgct tgaataccct agcctctcta ggttatgtgg ttgtagtgat agacaacagg   2280

ggatcctgtc accgagggct taaatttgaa ggcgccttta aatataaaat gggtcaaata   2340

gaaattgacg atcaggtgga aggactccaa tatctagctt ctcgatatga tttcattgac   2400

ttagatcgtg tgggcatcca cggctggtcc tatggaggat acctctccct gatggcatta   2460

atgcagaggt cagatatctt cagggttgct attgctgggg ccccagtcac tctgtggatc   2520

ttctatgata caggatacac ggaacgttat atgggtcacc ctgaccagaa tgaacagggc   2580

tattacttag gatctgtggc catgcaagca gaaaagttcc cctctgaacc aaatcgttta   2640

ctgctcttac atggtttcct ggatgagaat gtccattttg cacataccag tatattactg   2700

agttttttag tgagggctgg aaagccatat gatttacaga tctatcctca ggagagacac   2760

agcataagag ttcctgaatc gggagaacat tatgaactgc atcttttgca ctaccttcaa   2820

gaaaaccttg gatcacgtat tgctgctcta aaagtgatat aattttgacc tgtgtagaac   2880

tctctggtat acactggcta tttaaccaaa tgaggaggtt taatcaacag aaaacacaga   2940

attgatcatc acattttgat acctgccatg taacatctac tcctgaaaat aaatgtggtg   3000

ccatgcaggg gtctacggtt tgtggtagta atctaatacc ttaaccccac atgctcaaaa   3060

tcaaatgata catattcctg agagacccag caataccata agaattacta aaaaaaaaaa   3120

aaaaaaaaag acattagcac catgtattca tactacccta ttttcacttt taatagtatt   3180

ataaacttca tgaacttaat tagtgtattt ttacagtata cttttgagtt tgttaaaata   3240

tgatgatatt agtgattggt ttggttcagt tccagaatct ttgactagtt acagatttga   3300

tagcacttaa atgtaattga atagcttatg cttcattgct tgggcatatc cagcatgtta   3360

tgaactaata actattaaac ttgacttaac cagtcattca ttaataattt ttcaaggata   3420

acttagtggc ctcctaaaga cacttgtttt ggcactgacc agtttttagc caatttaatc   3480

tgtatctagt ataaataatt ctcatttttc tttgatgata ttaacagagt gggcttttcc   3540

ttttgcataa aggctagtaa ctgtatatgt agcatggatt taattagtca tgatattgat   3600

aattacaggc agaaaatttt taatcaaatg attagagctt aaatatttgc aggcaagttt   3660

ttttttttcc tttaagaaaa ggaaaaagta cacattcact agaattcttc agaaaattta   3720

gtggtgccag tttccatttg gtatttcctt attaaaatat tctagaattt taaggagatt   3780

gaagggaatc acagtggggt ggggagacct gggtttgggg aatgacagag agaagaggtg   3840

gtgagggcct gattaaaaac taagcagaag tagttttaac aaaaatactc atgaaaatgt   3900

ttggaaactg aaatttaaac aactgtaata ttaaggaaac cagaatcaat aaatcactgt   3960

cttgccagca cagctacaga gtaacatgat tcaggggagg aaaagttcct tagagttact   4020

tttataattc tttttttttt tcctcttagg tttagaaatc ttacaaattt aaactttatc   4080

ctttta                                                              4086


<210>  3301
<211>  898
<212>  PRT
<213>  Homosapiens

<400>  3301

Met Trp Lys Arg Ser Glu Gln Met Lys Ile Lys Ser Gly Lys Cys Asn 
1               5                   10                  15      


Met Ala Ala Ala Met Glu Thr Glu Gln Leu Gly Val Glu Ile Phe Glu 
            20                  25                  30          


Thr Ala Asp Cys Glu Glu Asn Ile Glu Ser Gln Asp Arg Pro Lys Leu 
        35                  40                  45              


Glu Pro Phe Tyr Val Glu Arg Tyr Ser Trp Ser Gln Leu Lys Lys Leu 
    50                  55                  60                  


Leu Ala Asp Thr Arg Lys Tyr His Gly Tyr Met Met Ala Lys Ala Pro 
65                  70                  75                  80  


His Asp Phe Met Phe Val Lys Arg Asn Asp Pro Asp Gly Pro His Ser 
                85                  90                  95      


Asp Arg Ile Tyr Tyr Leu Ala Met Ser Gly Glu Asn Arg Glu Asn Thr 
            100                 105                 110         


Leu Phe Tyr Ser Glu Ile Pro Lys Thr Ile Asn Arg Ala Ala Val Leu 
        115                 120                 125             


Met Leu Ser Trp Lys Pro Leu Leu Asp Leu Phe Gln Ala Thr Leu Asp 
    130                 135                 140                 


Tyr Gly Met Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg 
145                 150                 155                 160 


Ile Gly Thr Val Gly Ile Ala Ser Tyr Asp Tyr His Gln Gly Ser Gly 
                165                 170                 175     


Thr Phe Leu Phe Gln Ala Gly Ser Gly Ile Tyr His Val Lys Asp Gly 
            180                 185                 190         


Gly Pro Gln Gly Phe Thr Gln Gln Pro Leu Arg Pro Asn Leu Val Glu 
        195                 200                 205             


Thr Ser Cys Pro Asn Ile Arg Met Asp Pro Lys Leu Cys Pro Ala Asp 
    210                 215                 220                 


Pro Asp Trp Ile Ala Phe Ile His Ser Asn Asp Ile Trp Ile Ser Asn 
225                 230                 235                 240 


Ile Val Thr Arg Glu Glu Arg Arg Leu Thr Tyr Val His Asn Glu Leu 
                245                 250                 255     


Ala Asn Met Glu Glu Asp Ala Arg Ser Ala Gly Val Ala Thr Phe Val 
            260                 265                 270         


Leu Gln Glu Glu Phe Asp Arg Tyr Ser Gly Tyr Trp Trp Cys Pro Lys 
        275                 280                 285             


Ala Glu Thr Thr Pro Ser Gly Gly Lys Ile Leu Arg Ile Leu Tyr Glu 
    290                 295                 300                 


Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr Ser Pro Met 
305                 310                 315                 320 


Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr Pro Lys Thr Gly Thr 
                325                 330                 335     


Ala Asn Pro Lys Val Thr Phe Lys Met Ser Glu Ile Met Ile Asp Ala 
            340                 345                 350         


Glu Gly Arg Ile Ile Asp Val Ile Asp Lys Glu Leu Ile Gln Pro Phe 
        355                 360                 365             


Glu Ile Leu Phe Glu Gly Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr 
    370                 375                 380                 


Pro Glu Gly Lys Tyr Ala Trp Ser Ile Leu Leu Asp Arg Ser Gln Thr 
385                 390                 395                 400 


Arg Leu Gln Ile Val Leu Ile Ser Pro Glu Leu Phe Ile Pro Val Glu 
                405                 410                 415     


Asp Asp Val Met Glu Arg Gln Arg Leu Ile Glu Ser Val Pro Asp Ser 
            420                 425                 430         


Val Thr Pro Leu Ile Ile Tyr Glu Glu Thr Thr Asp Ile Trp Ile Asn 
        435                 440                 445             


Ile His Asp Ile Phe His Val Phe Pro Gln Ser His Glu Glu Glu Ile 
    450                 455                 460                 


Glu Phe Ile Phe Ala Ser Glu Cys Lys Thr Gly Phe Arg His Leu Tyr 
465                 470                 475                 480 


Lys Ile Thr Ser Ile Leu Lys Glu Ser Lys Tyr Lys Arg Ser Ser Gly 
                485                 490                 495     


Gly Leu Pro Ala Pro Ser Asp Phe Lys Cys Pro Ile Lys Glu Glu Ile 
            500                 505                 510         


Ala Ile Thr Ser Gly Glu Trp Glu Val Leu Gly Arg His Gly Ser Asn 
        515                 520                 525             


Ile Gln Val Asp Glu Val Arg Arg Leu Val Tyr Phe Glu Gly Thr Lys 
    530                 535                 540                 


Asp Ser Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Val Asn Pro 
545                 550                 555                 560 


Gly Glu Val Thr Arg Leu Thr Asp Arg Gly Tyr Ser His Ser Cys Cys 
                565                 570                 575     


Ile Ser Gln His Cys Asp Phe Phe Ile Ser Lys Tyr Ser Asn Gln Lys 
            580                 585                 590         


Asn Pro His Cys Val Ser Leu Tyr Lys Leu Ser Ser Pro Glu Asp Asp 
        595                 600                 605             


Pro Thr Cys Lys Thr Lys Glu Phe Trp Ala Thr Ile Leu Asp Ser Ala 
    610                 615                 620                 


Gly Pro Leu Pro Asp Tyr Thr Pro Pro Glu Ile Phe Ser Phe Glu Ser 
625                 630                 635                 640 


Thr Thr Gly Phe Thr Leu Tyr Gly Met Leu Tyr Lys Pro His Asp Leu 
                645                 650                 655     


Gln Pro Gly Lys Lys Tyr Pro Thr Val Leu Phe Ile Tyr Gly Gly Pro 
            660                 665                 670         


Gln Val Gln Leu Val Asn Asn Arg Phe Lys Gly Val Lys Tyr Phe Arg 
        675                 680                 685             


Leu Asn Thr Leu Ala Ser Leu Gly Tyr Val Val Val Val Ile Asp Asn 
    690                 695                 700                 


Arg Gly Ser Cys His Arg Gly Leu Lys Phe Glu Gly Ala Phe Lys Tyr 
705                 710                 715                 720 


Lys Met Gly Gln Ile Glu Ile Asp Asp Gln Val Glu Gly Leu Gln Tyr 
                725                 730                 735     


Leu Ala Ser Arg Tyr Asp Phe Ile Asp Leu Asp Arg Val Gly Ile His 
            740                 745                 750         


Gly Trp Ser Tyr Gly Gly Tyr Leu Ser Leu Met Ala Leu Met Gln Arg 
        755                 760                 765             


Ser Asp Ile Phe Arg Val Ala Ile Ala Gly Ala Pro Val Thr Leu Trp 
    770                 775                 780                 


Ile Phe Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met Gly His Pro Asp 
785                 790                 795                 800 


Gln Asn Glu Gln Gly Tyr Tyr Leu Gly Ser Val Ala Met Gln Ala Glu 
                805                 810                 815     


Lys Phe Pro Ser Glu Pro Asn Arg Leu Leu Leu Leu His Gly Phe Leu 
            820                 825                 830         


Asp Glu Asn Val His Phe Ala His Thr Ser Ile Leu Leu Ser Phe Leu 
        835                 840                 845             


Val Arg Ala Gly Lys Pro Tyr Asp Leu Gln Ile Tyr Pro Gln Glu Arg 
    850                 855                 860                 


His Ser Ile Arg Val Pro Glu Ser Gly Glu His Tyr Glu Leu His Leu 
865                 870                 875                 880 


Leu His Tyr Leu Gln Glu Asn Leu Gly Ser Arg Ile Ala Ala Leu Lys 
                885                 890                 895     


Val Ile 
        


<210>  3302
<211>  4079
<212>  DNA
<213>  Homosapiens

<400>  3302
aacgaaccgg aagtgctaaa gcctccgagg ccaaggccgc tgctactgcc gccgctgctt     60

cttagtgccg cgttcgccgc ctgggttgtc accggcgccg ccgccgagga agccactgca    120

accaggaccg gagtggaggc ggcgcagcat gaagcggcgc aggcccgctc catagcgcac    180

gtcgggacgg tccgggcggg gccgggggga aggctttgat ggtgaggaaa ggaaagattc    240

ctgtgagaag agcaggatga gcagagggat tctatgcttg aagtcgagtc acttgaaaaa    300

gatctctttg aatgtggaag agatctgagc agatgaaaat aaaatcagga aaatgcaaca    360

tggcagcagc aatggaaaca gaacagctgg gtgttgagat atttgaaact gcggactgtg    420

aggagaatat tgaatcacag gatcggccta aattggagcc tttttatgtt gagcggtatt    480

cctggagtca gcttaaaaag ctgcttgccg ataccagaaa atatcatggc tacatgatgg    540

ctaaggcacc acatgatttc atgtttgtga agaggaatga tccagatgga cctcattcag    600

acagaatcta ttaccttgcc atgtctggtg agaacagaga aaatacactg ttttattctg    660

aaattcccaa aactatcaat agagcagcag tcttaatgct ctcttggaag cctcttttgg    720

atctttttca ggcaacactg gactatggaa tgtattctcg agaagaagaa ctattaagag    780

aaagaaaacg cattggaaca gtcggaattg cttcttacga ttatcaccaa ggaagtggaa    840

catttctgtt tcaagccggt agtggaattt atcacgtaaa agatggaggg ccacaaggat    900

ttacgcaaca acctttaagg cccaatctag tggaaactag ttgtcccaac atacggatgg    960

atccaaaatt atgccctgct gatccagact ggattgcttt tatacatagc aacgatattt   1020

ggatatctaa catcgtaacc agagaagaaa ggagactcac ttatgtgcac aatgagctag   1080

ccaacatgga agaagatgcc agatcagctg gagtcgctac ctttgttctc caagaagaat   1140

ttgatagata ttctggctat tggtggtgtc caaaagctga aacaactccc agtggtggta   1200

aaattcttag aattctatat gaagaaaatg atgaatctga ggtggaaatt attcatgtta   1260

catcccctat gttggaaaca aggagggcag attcattccg ttatcctaaa acaggtacag   1320

caaatcctaa agtcactttt aagatgtcag aaataatgat tgatgctgaa ggaaggatca   1380

tagatgtcat agataaggaa ctaattcaac cttttgagat tctatttgaa ggagttgaat   1440

atattgccag agctggatgg actcctgagg gaaaatatgc ttggtccatc ctactagatc   1500

gctcccagac tcgcctacag atagtgttga tctcacctga attatttatc ccagtagaag   1560

atgatgttat ggaaaggcag agactcattg agtcagtgcc tgattctgtg acgccactaa   1620

ttatctatga agaaacaaca gacatctgga taaatatcca tgacatcttt catgtttttc   1680

cccaaagtca cgaagaggaa attgagttta tttttgcctc tgaatgcaaa acaggtttcc   1740

gtcatttata caaaattaca tctattttaa aggaaagcaa atataaacga tccagtggtg   1800

ggctgcctgc tccaagtgat ttcaagtgtc ctatcaaaga ggagatagca attaccagtg   1860

gtgaatggga agttcttggc cggcatggat ctaatatcca agttgatgaa gtcagaaggc   1920

tggtatattt tgaaggcacc aaagactccc ctttagagca tcacctgtac gtagtcagtt   1980

acgtaaatcc tggagaggtg acaaggctga ctgaccgtgg ctactcacat tcttgctgca   2040

tcagtcagca ctgtgacttc tttataagta agtatagtaa ccagaagaat ccacactgtg   2100

tgtcccttta caagctatca agtcctgaag atgacccaac ttgcaaaaca aaggaatttt   2160

gggccaccat tttggattca gcaggtcctc ttcctgacta tactcctcca gaaattttct   2220

cttttgaaag tactactgga tttacattgt atgggatgct ctacaagcct catgatctac   2280

agcctggaaa gaaatatcct actgtgctgt tcatatatgg tggtcctcag gtgcagttgg   2340

tgaataatcg gtttaaagga gtcaagtatt tccgcttgaa taccctagcc tctctaggtt   2400

atgtggttgt agtgatagac aacaggggat cctgtcaccg agggcttaaa tttgaaggcg   2460

cctttaaata taaaatggtt gctattgctg gggccccagt cactctgtgg atcttctatg   2520

atacaggata cacggaacgt tatatgggtc accctgacca gaatgaacag ggctattact   2580

taggatctgt ggccatgcaa gcagaaaagt tcccctctga accaaatcgt ttactgctct   2640

tacatggttt cctggatgag aatgtccatt ttgcacatac cagtatatta ctgagttttt   2700

tagtgagggc tggaaagcca tatgatttac agatctatcc tcaggagaga cacagcataa   2760

gagttcctga atcgggagaa cattatgaac tgcatctttt gcactacctt caagaaaacc   2820

ttggatcacg tattgctgct ctaaaagtga tataattttg acctgtgtag aactctctgg   2880

tatacactgg ctatttaacc aaatgaggag gtttaatcaa cagaaaacac agaattgatc   2940

atcacatttt gatacctgcc atgtaacatc tactcctgaa aataaatgtg gtgccatgca   3000

ggggtctacg gtttgtggta gtaatctaat accttaaccc cacatgctca aaatcaaatg   3060

atacatattc ctgagagacc cagcaatacc ataagaatta ctaaaaaaaa aaaaaaaaaa   3120

aagacattag caccatgtat tcatactacc ctattttcac ttttaatagt attataaact   3180

tcatgaactt aattagtgta tttttacagt atacttttga gtttgttaaa atatgatgat   3240

attagtgatt ggtttggttc agttccagaa tctttgacta gttacagatt tgatagcact   3300

taaatgtaat tgaatagctt atgcttcatt gcttgggcat atccagcatg ttatgaacta   3360

ataactatta aacttgactt aaccagtcat tcattaataa tttttcaagg ataacttagt   3420

ggcctcctaa agacacttgt tttggcactg accagttttt agccaattta atctgtatct   3480

agtataaata attctcattt ttctttgatg atattaacag agtgggcttt tccttttgca   3540

taaaggctag taactgtata tgtagcatgg atttaattag tcatgatatt gataattaca   3600

ggcagaaaat ttttaatcaa atgattagag cttaaatatt tgcaggcaag tttttttttt   3660

tcctttaaga aaaggaaaaa gtacacattc actagaattc ttcagaaaat ttagtggtgc   3720

cagtttccat ttggtatttc cttattaaaa tattctagaa ttttaaggag attgaaggga   3780

atcacagtgg ggtggggaga cctgggtttg gggaatgaca gagagaagag gtggtgaggg   3840

cctgattaaa aactaagcag aagtagtttt aacaaaaata ctcatgaaaa tgtttggaaa   3900

ctgaaattta aacaactgta atattaagga aaccagaatc aataaatcac tgtcttgcca   3960

gcacagctac agagtaacat gattcagggg aggaaaagtt ccttagagtt acttttataa   4020

ttcttttttt ttttcctctt aggtttagaa atcttacaaa tttaaacttt atcctttta    4079


<210>  3303
<211>  847
<212>  PRT
<213>  Homosapiens

<400>  3303

Met Trp Lys Arg Ser Glu Gln Met Lys Ile Lys Ser Gly Lys Cys Asn 
1               5                   10                  15      


Met Ala Ala Ala Met Glu Thr Glu Gln Leu Gly Val Glu Ile Phe Glu 
            20                  25                  30          


Thr Ala Asp Cys Glu Glu Asn Ile Glu Ser Gln Asp Arg Pro Lys Leu 
        35                  40                  45              


Glu Pro Phe Tyr Val Glu Arg Tyr Ser Trp Ser Gln Leu Lys Lys Leu 
    50                  55                  60                  


Leu Ala Asp Thr Arg Lys Tyr His Gly Tyr Met Met Ala Lys Ala Pro 
65                  70                  75                  80  


His Asp Phe Met Phe Val Lys Arg Asn Asp Pro Asp Gly Pro His Ser 
                85                  90                  95      


Asp Arg Ile Tyr Tyr Leu Ala Met Ser Gly Glu Asn Arg Glu Asn Thr 
            100                 105                 110         


Leu Phe Tyr Ser Glu Ile Pro Lys Thr Ile Asn Arg Ala Ala Val Leu 
        115                 120                 125             


Met Leu Ser Trp Lys Pro Leu Leu Asp Leu Phe Gln Ala Thr Leu Asp 
    130                 135                 140                 


Tyr Gly Met Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg 
145                 150                 155                 160 


Ile Gly Thr Val Gly Ile Ala Ser Tyr Asp Tyr His Gln Gly Ser Gly 
                165                 170                 175     


Thr Phe Leu Phe Gln Ala Gly Ser Gly Ile Tyr His Val Lys Asp Gly 
            180                 185                 190         


Gly Pro Gln Gly Phe Thr Gln Gln Pro Leu Arg Pro Asn Leu Val Glu 
        195                 200                 205             


Thr Ser Cys Pro Asn Ile Arg Met Asp Pro Lys Leu Cys Pro Ala Asp 
    210                 215                 220                 


Pro Asp Trp Ile Ala Phe Ile His Ser Asn Asp Ile Trp Ile Ser Asn 
225                 230                 235                 240 


Ile Val Thr Arg Glu Glu Arg Arg Leu Thr Tyr Val His Asn Glu Leu 
                245                 250                 255     


Ala Asn Met Glu Glu Asp Ala Arg Ser Ala Gly Val Ala Thr Phe Val 
            260                 265                 270         


Leu Gln Glu Glu Phe Asp Arg Tyr Ser Gly Tyr Trp Trp Cys Pro Lys 
        275                 280                 285             


Ala Glu Thr Thr Pro Ser Gly Gly Lys Ile Leu Arg Ile Leu Tyr Glu 
    290                 295                 300                 


Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr Ser Pro Met 
305                 310                 315                 320 


Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr Pro Lys Thr Gly Thr 
                325                 330                 335     


Ala Asn Pro Lys Val Thr Phe Lys Met Ser Glu Ile Met Ile Asp Ala 
            340                 345                 350         


Glu Gly Arg Ile Ile Asp Val Ile Asp Lys Glu Leu Ile Gln Pro Phe 
        355                 360                 365             


Glu Ile Leu Phe Glu Gly Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr 
    370                 375                 380                 


Pro Glu Gly Lys Tyr Ala Trp Ser Ile Leu Leu Asp Arg Ser Gln Thr 
385                 390                 395                 400 


Arg Leu Gln Ile Val Leu Ile Ser Pro Glu Leu Phe Ile Pro Val Glu 
                405                 410                 415     


Asp Asp Val Met Glu Arg Gln Arg Leu Ile Glu Ser Val Pro Asp Ser 
            420                 425                 430         


Val Thr Pro Leu Ile Ile Tyr Glu Glu Thr Thr Asp Ile Trp Ile Asn 
        435                 440                 445             


Ile His Asp Ile Phe His Val Phe Pro Gln Ser His Glu Glu Glu Ile 
    450                 455                 460                 


Glu Phe Ile Phe Ala Ser Glu Cys Lys Thr Gly Phe Arg His Leu Tyr 
465                 470                 475                 480 


Lys Ile Thr Ser Ile Leu Lys Glu Ser Lys Tyr Lys Arg Ser Ser Gly 
                485                 490                 495     


Gly Leu Pro Ala Pro Ser Asp Phe Lys Cys Pro Ile Lys Glu Glu Ile 
            500                 505                 510         


Ala Ile Thr Ser Gly Glu Trp Glu Val Leu Gly Arg His Gly Ser Asn 
        515                 520                 525             


Ile Gln Val Asp Glu Val Arg Arg Leu Val Tyr Phe Glu Gly Thr Lys 
    530                 535                 540                 


Asp Ser Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Val Asn Pro 
545                 550                 555                 560 


Gly Glu Val Thr Arg Leu Thr Asp Arg Gly Tyr Ser His Ser Cys Cys 
                565                 570                 575     


Ile Ser Gln His Cys Asp Phe Phe Ile Ser Lys Tyr Ser Asn Gln Lys 
            580                 585                 590         


Asn Pro His Cys Val Ser Leu Tyr Lys Leu Ser Ser Pro Glu Asp Asp 
        595                 600                 605             


Pro Thr Cys Lys Thr Lys Glu Phe Trp Ala Thr Ile Leu Asp Ser Ala 
    610                 615                 620                 


Gly Pro Leu Pro Asp Tyr Thr Pro Pro Glu Ile Phe Ser Phe Glu Ser 
625                 630                 635                 640 


Thr Thr Gly Phe Thr Leu Tyr Gly Met Leu Tyr Lys Pro His Asp Leu 
                645                 650                 655     


Gln Pro Gly Lys Lys Tyr Pro Thr Val Leu Phe Ile Tyr Gly Gly Pro 
            660                 665                 670         


Gln Val Gln Leu Val Asn Asn Arg Phe Lys Gly Val Lys Tyr Phe Arg 
        675                 680                 685             


Leu Asn Thr Leu Ala Ser Leu Gly Tyr Val Val Val Val Ile Asp Asn 
    690                 695                 700                 


Arg Gly Ser Cys His Arg Gly Leu Lys Phe Glu Gly Ala Phe Lys Tyr 
705                 710                 715                 720 


Lys Met Val Ala Ile Ala Gly Ala Pro Val Thr Leu Trp Ile Phe Tyr 
                725                 730                 735     


Asp Thr Gly Tyr Thr Glu Arg Tyr Met Gly His Pro Asp Gln Asn Glu 
            740                 745                 750         


Gln Gly Tyr Tyr Leu Gly Ser Val Ala Met Gln Ala Glu Lys Phe Pro 
        755                 760                 765             


Ser Glu Pro Asn Arg Leu Leu Leu Leu His Gly Phe Leu Asp Glu Asn 
    770                 775                 780                 


Val His Phe Ala His Thr Ser Ile Leu Leu Ser Phe Leu Val Arg Ala 
785                 790                 795                 800 


Gly Lys Pro Tyr Asp Leu Gln Ile Tyr Pro Gln Glu Arg His Ser Ile 
                805                 810                 815     


Arg Val Pro Glu Ser Gly Glu His Tyr Glu Leu His Leu Leu His Tyr 
            820                 825                 830         


Leu Gln Glu Asn Leu Gly Ser Arg Ile Ala Ala Leu Lys Val Ile 
        835                 840                 845         


<210>  3304
<211>  1689
<212>  DNA
<213>  Homosapiens

<400>  3304
cgggagcgtg gggtatctcg aggtgccggg ttgcaggcgc tcaggggcgc tagggtttga     60

ggcctgcttt ctgctcgcgc cagcagagca ctacctgagg cagcgaggcg cagcgagcct    120

agcctccccg cgccctgggc agtgtggcca tggagaatca ggtgttgacg ccgcatgtct    180

actgggctca gcgacaccgc gagctatatc tgcgcgtgga gctgagtgac gtacagaacc    240

ctgccatcag catcactgaa aacgtgctgc atttcaaagc tcaaggacat ggtgccaaag    300

gagacaatgt ctatgaattt cacctggagt tcttagacct tgtgaaacca gagcctgttt    360

acaaactgac ccagaggcag gtaaacatta cagtacagaa gaaagtgagt cagtggtggg    420

agagactcac aaagcaggaa aagcgaccac tgtttttggc tcctgacttt gatcgttggc    480

tggatgaatc tgatgcggaa atggagctca gagctaagga agaagagcgc ctaaataaac    540

tccgactgga aagcgaaggc tctcctgaaa ctcttacaaa cttaaggaaa ggatacctgt    600

ttatgtataa tcttgtgcaa ttcttgggat tctcctggat ctttgtcaac ctgactgtgc    660

gattctgtat cttgggaaaa gagtcctttt atgacacatt ccatactgtg gctgacatga    720

tgtatttctg ccagatgctg gcagttgtgg aaactatcaa tgcagcaatt ggagtcacta    780

cgtcaccggt gctgccttct ctgatccagc ttcttggaag aaattttatt ttgtttatca    840

tctttggcac catggaagaa atgcagaaca aagctgtggt tttctttgtg ttttatttgt    900

ggagtgcaat tgaaattttc aggtactctt tctacatgct gacgtgcatt gacatggatt    960

ggaaggtgct cacatggctt cgttacactc tgtggattcc cttatatcca ctgggatgtt   1020

tggtggaagc tgtctcagtg attcagtcca ttccaatatt caatgagacc ggacgattca   1080

gtttcacatt gccatatcca gtgaaaatca aagttagatt ttcctttttt cttcagattt   1140

atcttataat gatattttta ggtttataca taaattttcg tcacctttat aaacagcgca   1200

gacggcgcta tggaaaaaaa agaaaaagat ccactaaaaa gaaagattta gatggcttct   1260

tgccagtttg agcctaatct gattcttaca gttttacctt cttgaaccaa tgtaaaagtt   1320

tttttaatgt taaatgatta aattctcagt gaggctatct tccttttccc cagtaacatt   1380

cctgaattta ctgttatctt attgtagtac ttgcatgaca tggattcctg atatctgatg   1440

agaggttcat tcttgtgtat tcagttaatg acaccaaaag gctcagccca ccccaaccct   1500

atctcatgtt cagtctgtct aatacatgcc agagattttt ttttcaaaaa gtgctttatc   1560

cctacaatgt actgacagtt cttacagttg aggatttggt tcttttcagc taattgcttg   1620

gtggattaaa aaaagcaaga ctaatgtcaa ctctaatgga aggctggtta aaagtggact   1680

caggcaagg                                                           1689


<210>  3305
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  3305

Met Glu Asn Gln Val Leu Thr Pro His Val Tyr Trp Ala Gln Arg His 
1               5                   10                  15      


Arg Glu Leu Tyr Leu Arg Val Glu Leu Ser Asp Val Gln Asn Pro Ala 
            20                  25                  30          


Ile Ser Ile Thr Glu Asn Val Leu His Phe Lys Ala Gln Gly His Gly 
        35                  40                  45              


Ala Lys Gly Asp Asn Val Tyr Glu Phe His Leu Glu Phe Leu Asp Leu 
    50                  55                  60                  


Val Lys Pro Glu Pro Val Tyr Lys Leu Thr Gln Arg Gln Val Asn Ile 
65                  70                  75                  80  


Thr Val Gln Lys Lys Val Ser Gln Trp Trp Glu Arg Leu Thr Lys Gln 
                85                  90                  95      


Glu Lys Arg Pro Leu Phe Leu Ala Pro Asp Phe Asp Arg Trp Leu Asp 
            100                 105                 110         


Glu Ser Asp Ala Glu Met Glu Leu Arg Ala Lys Glu Glu Glu Arg Leu 
        115                 120                 125             


Asn Lys Leu Arg Leu Glu Ser Glu Gly Ser Pro Glu Thr Leu Thr Asn 
    130                 135                 140                 


Leu Arg Lys Gly Tyr Leu Phe Met Tyr Asn Leu Val Gln Phe Leu Gly 
145                 150                 155                 160 


Phe Ser Trp Ile Phe Val Asn Leu Thr Val Arg Phe Cys Ile Leu Gly 
                165                 170                 175     


Lys Glu Ser Phe Tyr Asp Thr Phe His Thr Val Ala Asp Met Met Tyr 
            180                 185                 190         


Phe Cys Gln Met Leu Ala Val Val Glu Thr Ile Asn Ala Ala Ile Gly 
        195                 200                 205             


Val Thr Thr Ser Pro Val Leu Pro Ser Leu Ile Gln Leu Leu Gly Arg 
    210                 215                 220                 


Asn Phe Ile Leu Phe Ile Ile Phe Gly Thr Met Glu Glu Met Gln Asn 
225                 230                 235                 240 


Lys Ala Val Val Phe Phe Val Phe Tyr Leu Trp Ser Ala Ile Glu Ile 
                245                 250                 255     


Phe Arg Tyr Ser Phe Tyr Met Leu Thr Cys Ile Asp Met Asp Trp Lys 
            260                 265                 270         


Val Leu Thr Trp Leu Arg Tyr Thr Leu Trp Ile Pro Leu Tyr Pro Leu 
        275                 280                 285             


Gly Cys Leu Val Glu Ala Val Ser Val Ile Gln Ser Ile Pro Ile Phe 
    290                 295                 300                 


Asn Glu Thr Gly Arg Phe Ser Phe Thr Leu Pro Tyr Pro Val Lys Ile 
305                 310                 315                 320 


Lys Val Arg Phe Ser Phe Phe Leu Gln Ile Tyr Leu Ile Met Ile Phe 
                325                 330                 335     


Leu Gly Leu Tyr Ile Asn Phe Arg His Leu Tyr Lys Gln Arg Arg Arg 
            340                 345                 350         


Arg Tyr Gly Lys Lys Arg Lys Arg Ser Thr Lys Lys Lys Asp Leu Asp 
        355                 360                 365             


Gly Phe Leu Pro Val 
    370             


<210>  3306
<211>  2538
<212>  DNA
<213>  Homosapiens

<400>  3306
tgcctttcgc tgcttgttgg ggttacaggt gaaggggtta tgggtgaaga acaacccagg     60

gccagcgctt ggccttcccg ccaccgtggc ggccgccccg cgctgtctgt gaggcgccag    120

ttccggggcg ctgctcccgg cctcccctcg ctctgaggct cggggtcccc agctccgcgt    180

aaactgcacg atttcgccct ctgctcagct cccctctgcc ccctctttcc aagagagact    240

tccagatccc acattttctt gactgatttt taagcatttc ttcgtttata gctgtctgtt    300

tgcattctga ttgggaacac tgggatcatt ttcatcatgc cgacagtggt ggtaatggat    360

gtatcccttt ccatgacccg acctgtgtct attgaggggt ccgaggaata ccagcgtaag    420

cacctagcag cccatggttt aacgatgctg tttgagcaca tggccacaaa ttacaagctt    480

gaatttacag cacttgtggt tttttcatca ctttgggagt tgatggtccc cttcacgaga    540

gattataata ccctacagga agcactaagt aatatggatg attatgacaa aacctgcttg    600

gggtctgcat tagttggtgt ttgcaatatc gttcagcaag aatggggtgg tgcaattcct    660

tgccaggttg tcctggtgac agacggctgt cttggcattg gtagagggtc actgcgacat    720

tccctagcca ctcaaaatca acgaagtgag agcaacaggt ttccactacc ttttcctttc    780

ccatctaagt tatatatcat gtgcatggcg aatttggagg agctccagag caccgattcc    840

ttggaatgcc ttgaacgtct catagattta aacaatggtg aagggcagat ttttactatt    900

gatggccccc tgtgcttgaa gaatgtacag tctatgtttg gaaaactgat aggtttggca    960

tatacgcctt tccatgctgt tctcaagtgt ggccacctaa ctgctgatgt acaagtcttc   1020

cccaggccag aaccttttgt tgtagatgaa gaaattgatc ctatccctaa agtcattaac   1080

acagatttgg aaatagtggg atttattgat atagctgata tctcaagtcc cccagttctg   1140

tccagacatc tggtcttacc tatagcactt aacaaagaag gtgatgaggt gggtactggc   1200

atcactgatg acaatgaaga tgaaaattca gccaatcaga ttgcaggcaa aatacccaac   1260

ttttgtgtcc tgctccatgg tagcctaaaa gtggaaggaa tggtagcgat tgttcaatta   1320

ggtcctgaat ggcatggaat gctctactcc caagctgaca gcaagaagaa atcaaacctc   1380

atgatgtctc tctttgagcc tggcccagaa cctctcccat ggctagggaa aatggcacag   1440

ttgggtccta tttcagatgc taaagaaaac ccttatggcg aggatgacaa taagagtcca   1500

ttccccctgc agcccaaaaa caagcgcagt tatgcccaga atgtgactgt ctggatcaaa   1560

cccagcggcc tgcagacaga tgtacagaag attttaagaa atgcaaggaa actacctgaa   1620

aaaacacaga cattctataa ggagctgaac cgtttgcgaa aggccgctct agcctttggt   1680

ttcctggacc tgctgaaagg ggtggctgac atgctggaaa gggaatgcac actgctgcct   1740

gagacagccc accctgatgc tgcattccag ctgacccatg ctgcccagca gctcaagctg   1800

gccagtaccg gcacctctga gtatgccgct tatgaccaga acatcacacc tttgcacacg   1860

gacttctctg ggagcagcac tgaaagaatt tgaaactgac ttttggagct ttccttcttt   1920

tttcatttca actgaaaatg ctttaggtaa aaacctttcc agtatgttca cctctagaat   1980

agccacccaa agaccttcct gaggctgcct cagaagcacc acttgctgtt ttgaatgact   2040

ctactagtat gagaaggatg tgaaggtggt tggctggttg ggctttaact tcctgggatt   2100

cataattttt aagcttggaa gatagctgct gttcccatga tgggcacatt tcctgagaag   2160

cttgaatgac tgatgagcat agagcacccc tgccttcctc aggaaacctg accggcaggg   2220

gctctctggc ttcctgaaag cttcacctct tccctcgttt atatctcaac tgtaagggca   2280

ttttcaagct tctgttcatg gaatgagcaa ctcagactgt ctggagcttg ctgagtacaa   2340

acacaccacc actaagtttc agaactttcc ttaggacttg ggcaaaatgt ggtggtaact   2400

cttaagtgct tttggtatct cttgagattc taacttttaa agagcaacca ttaatgtgta   2460

aaatgattcc tattattcaa ggtttttttt taatgaaaat aaaatatttg attttctaga   2520

aaaaaaaaaa aaaaaaaa                                                 2538


<210>  3307
<211>  518
<212>  PRT
<213>  Homosapiens

<400>  3307

Met Pro Thr Val Val Val Met Asp Val Ser Leu Ser Met Thr Arg Pro 
1               5                   10                  15      


Val Ser Ile Glu Gly Ser Glu Glu Tyr Gln Arg Lys His Leu Ala Ala 
            20                  25                  30          


His Gly Leu Thr Met Leu Phe Glu His Met Ala Thr Asn Tyr Lys Leu 
        35                  40                  45              


Glu Phe Thr Ala Leu Val Val Phe Ser Ser Leu Trp Glu Leu Met Val 
    50                  55                  60                  


Pro Phe Thr Arg Asp Tyr Asn Thr Leu Gln Glu Ala Leu Ser Asn Met 
65                  70                  75                  80  


Asp Asp Tyr Asp Lys Thr Cys Leu Gly Ser Ala Leu Val Gly Val Cys 
                85                  90                  95      


Asn Ile Val Gln Gln Glu Trp Gly Gly Ala Ile Pro Cys Gln Val Val 
            100                 105                 110         


Leu Val Thr Asp Gly Cys Leu Gly Ile Gly Arg Gly Ser Leu Arg His 
        115                 120                 125             


Ser Leu Ala Thr Gln Asn Gln Arg Ser Glu Ser Asn Arg Phe Pro Leu 
    130                 135                 140                 


Pro Phe Pro Phe Pro Ser Lys Leu Tyr Ile Met Cys Met Ala Asn Leu 
145                 150                 155                 160 


Glu Glu Leu Gln Ser Thr Asp Ser Leu Glu Cys Leu Glu Arg Leu Ile 
                165                 170                 175     


Asp Leu Asn Asn Gly Glu Gly Gln Ile Phe Thr Ile Asp Gly Pro Leu 
            180                 185                 190         


Cys Leu Lys Asn Val Gln Ser Met Phe Gly Lys Leu Ile Gly Leu Ala 
        195                 200                 205             


Tyr Thr Pro Phe His Ala Val Leu Lys Cys Gly His Leu Thr Ala Asp 
    210                 215                 220                 


Val Gln Val Phe Pro Arg Pro Glu Pro Phe Val Val Asp Glu Glu Ile 
225                 230                 235                 240 


Asp Pro Ile Pro Lys Val Ile Asn Thr Asp Leu Glu Ile Val Gly Phe 
                245                 250                 255     


Ile Asp Ile Ala Asp Ile Ser Ser Pro Pro Val Leu Ser Arg His Leu 
            260                 265                 270         


Val Leu Pro Ile Ala Leu Asn Lys Glu Gly Asp Glu Val Gly Thr Gly 
        275                 280                 285             


Ile Thr Asp Asp Asn Glu Asp Glu Asn Ser Ala Asn Gln Ile Ala Gly 
    290                 295                 300                 


Lys Ile Pro Asn Phe Cys Val Leu Leu His Gly Ser Leu Lys Val Glu 
305                 310                 315                 320 


Gly Met Val Ala Ile Val Gln Leu Gly Pro Glu Trp His Gly Met Leu 
                325                 330                 335     


Tyr Ser Gln Ala Asp Ser Lys Lys Lys Ser Asn Leu Met Met Ser Leu 
            340                 345                 350         


Phe Glu Pro Gly Pro Glu Pro Leu Pro Trp Leu Gly Lys Met Ala Gln 
        355                 360                 365             


Leu Gly Pro Ile Ser Asp Ala Lys Glu Asn Pro Tyr Gly Glu Asp Asp 
    370                 375                 380                 


Asn Lys Ser Pro Phe Pro Leu Gln Pro Lys Asn Lys Arg Ser Tyr Ala 
385                 390                 395                 400 


Gln Asn Val Thr Val Trp Ile Lys Pro Ser Gly Leu Gln Thr Asp Val 
                405                 410                 415     


Gln Lys Ile Leu Arg Asn Ala Arg Lys Leu Pro Glu Lys Thr Gln Thr 
            420                 425                 430         


Phe Tyr Lys Glu Leu Asn Arg Leu Arg Lys Ala Ala Leu Ala Phe Gly 
        435                 440                 445             


Phe Leu Asp Leu Leu Lys Gly Val Ala Asp Met Leu Glu Arg Glu Cys 
    450                 455                 460                 


Thr Leu Leu Pro Glu Thr Ala His Pro Asp Ala Ala Phe Gln Leu Thr 
465                 470                 475                 480 


His Ala Ala Gln Gln Leu Lys Leu Ala Ser Thr Gly Thr Ser Glu Tyr 
                485                 490                 495     


Ala Ala Tyr Asp Gln Asn Ile Thr Pro Leu His Thr Asp Phe Ser Gly 
            500                 505                 510         


Ser Ser Thr Glu Arg Ile 
        515             


<210>  3308
<211>  5374
<212>  DNA
<213>  Homosapiens

<400>  3308
cccttcacac ccgacccagc cttgaattag gattccatag gagagctggg ggcaggagaa     60

tggggtgttc cctgctgtcc agcttcagac ccactctttg agatattgga ttctgacaag    120

tttccagagc tgagaagaca gccagatgtc aaggtctgaa gggttgtgga taccccctgg    180

ctgggcttca tggagaaatc ttctctgatc accaacctga atcccagagt agcctccatc    240

ttaggacaga atgagaggcc ttctgtaacc agatataact ggccagcatg gggaaattga    300

tcaggatggg gccgcaagag aggtggttac tccggacaaa gcggcttcat tggagtcgcc    360

tcctcttctt actgggaatg ttgatcatcg gttctactta tcagcacctt aggagacccc    420

ggggcctttc ctcattgtgg gcagcagtct cttctcatca gcctataaaa ctggccagtc    480

gggacctctc cagtgaagag atgatgatga tgagcagcag cccttcaaaa cctagctccg    540

aaatgggggg taagatgctg gtaccccaag cctcagtggg cagtgatgaa gcaacactga    600

gcatgacagt ggagaatatc cccagtatgc ctaaaagaac agccaagatg atcccaacaa    660

caaccaagaa taattacagc ccaacagcag caggtacaga aagaaggaag gaagacaccc    720

caacatccag tagaacactg acttactaca cctcaacttc aagcagacaa atagtaaaaa    780

agtatacccc aacacccagg ggagaaatga agagctacag cccaactcaa gtgagggaaa    840

aggtgaagta tactccttcc ccacgtggta gaagagtagg cacttacgtg ccgtccacat    900

tcatgacaat ggaaacaagc catgcgatca cccccaggac aacagtgaaa gacagtgaca    960

ttacagcaac ctataaaata ctcgaaacca actctcttaa gagaataatg gaggaaacca   1020

ccccaaccac tctcaaggga atgtttgata gcaccccaac ttttctgaca catgaggtag   1080

aagcaaacgt cttgacttct ccaaggagcg tcatggaaaa aaacaacctg tttcccccca   1140

gaagagtgga aagtaacagc tcagcccatc cctgggggtt agtgggaaag agcaacccga   1200

agactcccca gggaacagtc ctgttgcata ccccagccac ctctgagggg caggtgacaa   1260

taagcaccat gacaggcagc agcccagcag aaaccaaagc cttcactgct gcctggagtc   1320

ttaggaatcc ttcacccagg accagtgtat cagccatcaa aacagcccca gccatagtct   1380

ggaggctggc aaagaaacct tccacagcac ccagcacctc aacaacccct acggtcaggg   1440

caaagctgac catgcaggtc catcactgtg tggttgtgaa gccaacccca gccatgctca   1500

ccactccctc cccaagcctc acaacagccc tgctcccaga ggagctcagt cctagtccct   1560

cagtgctgcc tcccagcttg ccagacctcc accccaaggg agagtacccc ccagatctgt   1620

tcagtgtgga ggagcggcgg cagggctggg tggtcctgca cgtttttggc atgatgtatg   1680

tgtttgtggc cttggccatt gtttgcgacg agtacttcgt tccagccctg ggtgtcatca   1740

cagacaagct gcagatctcc gaggatgtgg caggcgccac attcatggct gctggaggct   1800

ctgctcctga gctcttcacc tccctcatcg gtgtcttcat ttcccacagc aacgtgggca   1860

ttggtaccat tgtgggctct gctgtgttca acattctctt tgtcattggc acttgttccc   1920

tcttctcccg agagatcctc aacctcacct ggtggccctt attccgtgat gtctccttct   1980

acatccttga cctgataatg ctcatcctct tcttcctgga cagcctcatt gcctggtggg   2040

agagcctgct gctgctgctg gcctatgcct tctatgtgtt caccatgaag tggaacaagc   2100

atatcgaggt ctgggtgaag gagcagctca gcaggaggcc agtggccaag gtcatggcct   2160

tagaagacct cagcaagccg ggcgatgggg ccattgcggt ggatgagcta caggataaca   2220

agaagctgaa gctcccgtcc ttgctgaccc gagggagcag ctcgacctct ctgcacaaca   2280

gcaccatccg cagcaccatc taccagctca tgctccacag cctggacccc ctgagggaag   2340

ttcgccttgc caaggagaag gaggaggaga gcttgaatca aggggccaga gcccaacccc   2400

aggccaaagc agaaagcaaa ccagaagagg aggagccagc caagctccct gcggtcacgg   2460

tcacaccagc ccctgttcca gacatcaagg gagatcagaa ggagaatcca ggcggtcagg   2520

aagatgtggc tgaggccgag agcacaggtg aaatgccagg cgaagagggc gaaactgctg   2580

gtgaaggtga aactgaagag aaaagtggag gtgaaactca accagaaggt gaaggtgaaa   2640

ctgaaacaca aggaaaagga gaagaatgtg aagatgaaaa tgaagcagaa ggaaaaggag   2700

acaatgaagg tgaagatgag ggtgaaatcc acgcagaaga tggtgaaatg aaaggtaatg   2760

aaggtgaaac tgaaagccag gaactcagtg ctgaaaatca cggtgaagcc aaaaatgatg   2820

agaaaggtgt agaagatgga gggggaagtg atggagggga tagcgaagag gaggaagagg   2880

aggaggaaga gcaggaggaa gaggaggagg aggaagagca ggaggaagag gaggaggagg   2940

aggaggaaga ggaggagaag ggaaatgaag agcctctgtc cctggactgg cctgaaacca   3000

ggcagaagca ggccatttac ctcttccttc tgcccatcgt gttcccactg tggctgacag   3060

tccccgacgt ccgaaggcag gagtctagga agttttttgt tttcaccttc ctgggatcta   3120

tcatgtggat agccatgttc tcatacctca tggtgtggtg ggctcaccag gttggtgaaa   3180

caatagggat ttctgaagag atcatgggcc tgacaatcct tgcagcaggc acatcaattc   3240

ctgacctcat caccagtgtg attgtcgctc gaaaaggcct gggagacatg gctgtgtcaa   3300

gctctgtggg cagtaacata tttgatatca ctgtgggctt gcctgttcct tggttgcttt   3360

tctctcttat caatggatta cagccagttc cagtcagcag caatggcttg ttttgtgcaa   3420

ttgttttgct ttttctcatg cttctgtttg tgatctcttc aattgcgtca tgtaaatgga   3480

gaatgaacaa gatcctgggc ttcacaatgt tcctccttta ctttgtattc ctgataatca   3540

gtgtgatgtt agaagatcga atcatatcct gtcctgtatc tgtctgaatc agtcactctt   3600

gctcacaatg ggcatggatc agaagaccat gcagaagtta ctgtatctct tgtgacccta   3660

atgaaagaat gtatatgatc ctggaaagtg aactgggtga cctaggacct ctgatatgaa   3720

tgtgatctga gactaaagtt tgtccttgga aacacctgca gctcattgtg gattaagaac   3780

ctcacccctg gaggggtgga gtttctaccc ctgactcatg cagacatcta ttacatggag   3840

gcagtagaag gacccctgga gccagagggt tttctaaatg agataactgg gggcaaaggt   3900

tgggataggc gcacgagcta taagacaagc tcctacgctc actgttccct gatcattcca   3960

aaggctgctg gcccaaaaga tgcagatgtg gtctacatct cagccttcct gacctctgcc   4020

ccaaacacac gctgcaattt tgtctcctcc ttttctgttc aaattgtgag gttctatcag   4080

gtttgtaatc actgtagctt cagttattgg tgagtctaag gatccaaggc tacagaaaaa   4140

aaagaaatat aacaggaatt aatgatcatt ccacgttttg tagcccactg catctggata   4200

tataccagta tttttctttt tttttttttt gagacagagt ttggctcttg ttgcccaggc   4260

tggtgtgcaa tggcgtgatc tcggcacacc acaaccttca cctccccggt tcaagcaatt   4320

ctcctgcctc agcctgaagt cgtgatctgc ccgcctcggc ctcccaaagt gctgggatta   4380

caggcgtcag ccaccgcgcc tggcctatac cagtattttc tagtttaaag gaggactaca   4440

ttaactctta ttgttgtgtt tctgaaaagt gaaatttaaa aagcagcctg aaaaataaaa   4500

atttataatt tgcccttgaa ttggaaggaa tggagattag ggaaggaaaa ctactctaga   4560

ggccatttaa aagtatgtat ttattagaac atcgaaattc gtgttgtctc catcagtggt   4620

caccttgagg gattagacat tctaatggaa tgtcctggct ccaccctcca gcatgttctc   4680

acccaacaat gacagttgag tggagtggga agggaagtca ttctaaagag tccaaagtca   4740

gtagcgccac atctggttta taaagtaaga gatccagtgg acaatgctat ttttgtatgc   4800

caacctagat aggattataa agcaagactg atttcttctg tggtttatga atgatcttaa   4860

ggtaattaca aaagggaaat tccaagaatg cataacacaa tgacaacatg gtgagaaaag   4920

tgcagtacta cttccaaggt ggctagtgta aaggacactt gagtttttaa aactgtggtt   4980

aaatgtttta tgtggaattt gatgagtttg tatattaaat accactgctt gctgctttta   5040

ctagaatcaa gttaagggac acgttagaaa tagaacagct taatatcact ggcttcagag   5100

caaaatgagc tcgggtgact gcagattatg atggtaaata tggctttaat tacaaacatg   5160

aggaatgatt cactgaagat gaaaagatag gacggatgtg atatgaaaaa aacccaaaca   5220

ttttggcatt gaatgatggc taaggtgttc caagtattcc atcttttaag atgaattgct   5280

taattaattg cctcgctacc ccaggattct cattctttgg aaataatttt tattaaattt   5340

caataaactg tgaatcccaa tggtatttta cttt                               5374


<210>  3309
<211>  1099
<212>  PRT
<213>  Homosapiens

<400>  3309

Met Gly Lys Leu Ile Arg Met Gly Pro Gln Glu Arg Trp Leu Leu Arg 
1               5                   10                  15      


Thr Lys Arg Leu His Trp Ser Arg Leu Leu Phe Leu Leu Gly Met Leu 
            20                  25                  30          


Ile Ile Gly Ser Thr Tyr Gln His Leu Arg Arg Pro Arg Gly Leu Ser 
        35                  40                  45              


Ser Leu Trp Ala Ala Val Ser Ser His Gln Pro Ile Lys Leu Ala Ser 
    50                  55                  60                  


Arg Asp Leu Ser Ser Glu Glu Met Met Met Met Ser Ser Ser Pro Ser 
65                  70                  75                  80  


Lys Pro Ser Ser Glu Met Gly Gly Lys Met Leu Val Pro Gln Ala Ser 
                85                  90                  95      


Val Gly Ser Asp Glu Ala Thr Leu Ser Met Thr Val Glu Asn Ile Pro 
            100                 105                 110         


Ser Met Pro Lys Arg Thr Ala Lys Met Ile Pro Thr Thr Thr Lys Asn 
        115                 120                 125             


Asn Tyr Ser Pro Thr Ala Ala Gly Thr Glu Arg Arg Lys Glu Asp Thr 
    130                 135                 140                 


Pro Thr Ser Ser Arg Thr Leu Thr Tyr Tyr Thr Ser Thr Ser Ser Arg 
145                 150                 155                 160 


Gln Ile Val Lys Lys Tyr Thr Pro Thr Pro Arg Gly Glu Met Lys Ser 
                165                 170                 175     


Tyr Ser Pro Thr Gln Val Arg Glu Lys Val Lys Tyr Thr Pro Ser Pro 
            180                 185                 190         


Arg Gly Arg Arg Val Gly Thr Tyr Val Pro Ser Thr Phe Met Thr Met 
        195                 200                 205             


Glu Thr Ser His Ala Ile Thr Pro Arg Thr Thr Val Lys Asp Ser Asp 
    210                 215                 220                 


Ile Thr Ala Thr Tyr Lys Ile Leu Glu Thr Asn Ser Leu Lys Arg Ile 
225                 230                 235                 240 


Met Glu Glu Thr Thr Pro Thr Thr Leu Lys Gly Met Phe Asp Ser Thr 
                245                 250                 255     


Pro Thr Phe Leu Thr His Glu Val Glu Ala Asn Val Leu Thr Ser Pro 
            260                 265                 270         


Arg Ser Val Met Glu Lys Asn Asn Leu Phe Pro Pro Arg Arg Val Glu 
        275                 280                 285             


Ser Asn Ser Ser Ala His Pro Trp Gly Leu Val Gly Lys Ser Asn Pro 
    290                 295                 300                 


Lys Thr Pro Gln Gly Thr Val Leu Leu His Thr Pro Ala Thr Ser Glu 
305                 310                 315                 320 


Gly Gln Val Thr Ile Ser Thr Met Thr Gly Ser Ser Pro Ala Glu Thr 
                325                 330                 335     


Lys Ala Phe Thr Ala Ala Trp Ser Leu Arg Asn Pro Ser Pro Arg Thr 
            340                 345                 350         


Ser Val Ser Ala Ile Lys Thr Ala Pro Ala Ile Val Trp Arg Leu Ala 
        355                 360                 365             


Lys Lys Pro Ser Thr Ala Pro Ser Thr Ser Thr Thr Pro Thr Val Arg 
    370                 375                 380                 


Ala Lys Leu Thr Met Gln Val His His Cys Val Val Val Lys Pro Thr 
385                 390                 395                 400 


Pro Ala Met Leu Thr Thr Pro Ser Pro Ser Leu Thr Thr Ala Leu Leu 
                405                 410                 415     


Pro Glu Glu Leu Ser Pro Ser Pro Ser Val Leu Pro Pro Ser Leu Pro 
            420                 425                 430         


Asp Leu His Pro Lys Gly Glu Tyr Pro Pro Asp Leu Phe Ser Val Glu 
        435                 440                 445             


Glu Arg Arg Gln Gly Trp Val Val Leu His Val Phe Gly Met Met Tyr 
    450                 455                 460                 


Val Phe Val Ala Leu Ala Ile Val Cys Asp Glu Tyr Phe Val Pro Ala 
465                 470                 475                 480 


Leu Gly Val Ile Thr Asp Lys Leu Gln Ile Ser Glu Asp Val Ala Gly 
                485                 490                 495     


Ala Thr Phe Met Ala Ala Gly Gly Ser Ala Pro Glu Leu Phe Thr Ser 
            500                 505                 510         


Leu Ile Gly Val Phe Ile Ser His Ser Asn Val Gly Ile Gly Thr Ile 
        515                 520                 525             


Val Gly Ser Ala Val Phe Asn Ile Leu Phe Val Ile Gly Thr Cys Ser 
    530                 535                 540                 


Leu Phe Ser Arg Glu Ile Leu Asn Leu Thr Trp Trp Pro Leu Phe Arg 
545                 550                 555                 560 


Asp Val Ser Phe Tyr Ile Leu Asp Leu Ile Met Leu Ile Leu Phe Phe 
                565                 570                 575     


Leu Asp Ser Leu Ile Ala Trp Trp Glu Ser Leu Leu Leu Leu Leu Ala 
            580                 585                 590         


Tyr Ala Phe Tyr Val Phe Thr Met Lys Trp Asn Lys His Ile Glu Val 
        595                 600                 605             


Trp Val Lys Glu Gln Leu Ser Arg Arg Pro Val Ala Lys Val Met Ala 
    610                 615                 620                 


Leu Glu Asp Leu Ser Lys Pro Gly Asp Gly Ala Ile Ala Val Asp Glu 
625                 630                 635                 640 


Leu Gln Asp Asn Lys Lys Leu Lys Leu Pro Ser Leu Leu Thr Arg Gly 
                645                 650                 655     


Ser Ser Ser Thr Ser Leu His Asn Ser Thr Ile Arg Ser Thr Ile Tyr 
            660                 665                 670         


Gln Leu Met Leu His Ser Leu Asp Pro Leu Arg Glu Val Arg Leu Ala 
        675                 680                 685             


Lys Glu Lys Glu Glu Glu Ser Leu Asn Gln Gly Ala Arg Ala Gln Pro 
    690                 695                 700                 


Gln Ala Lys Ala Glu Ser Lys Pro Glu Glu Glu Glu Pro Ala Lys Leu 
705                 710                 715                 720 


Pro Ala Val Thr Val Thr Pro Ala Pro Val Pro Asp Ile Lys Gly Asp 
                725                 730                 735     


Gln Lys Glu Asn Pro Gly Gly Gln Glu Asp Val Ala Glu Ala Glu Ser 
            740                 745                 750         


Thr Gly Glu Met Pro Gly Glu Glu Gly Glu Thr Ala Gly Glu Gly Glu 
        755                 760                 765             


Thr Glu Glu Lys Ser Gly Gly Glu Thr Gln Pro Glu Gly Glu Gly Glu 
    770                 775                 780                 


Thr Glu Thr Gln Gly Lys Gly Glu Glu Cys Glu Asp Glu Asn Glu Ala 
785                 790                 795                 800 


Glu Gly Lys Gly Asp Asn Glu Gly Glu Asp Glu Gly Glu Ile His Ala 
                805                 810                 815     


Glu Asp Gly Glu Met Lys Gly Asn Glu Gly Glu Thr Glu Ser Gln Glu 
            820                 825                 830         


Leu Ser Ala Glu Asn His Gly Glu Ala Lys Asn Asp Glu Lys Gly Val 
        835                 840                 845             


Glu Asp Gly Gly Gly Ser Asp Gly Gly Asp Ser Glu Glu Glu Glu Glu 
    850                 855                 860                 


Glu Glu Glu Glu Gln Glu Glu Glu Glu Glu Glu Glu Glu Gln Glu Glu 
865                 870                 875                 880 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Lys Gly Asn Glu Glu Pro 
                885                 890                 895     


Leu Ser Leu Asp Trp Pro Glu Thr Arg Gln Lys Gln Ala Ile Tyr Leu 
            900                 905                 910         


Phe Leu Leu Pro Ile Val Phe Pro Leu Trp Leu Thr Val Pro Asp Val 
        915                 920                 925             


Arg Arg Gln Glu Ser Arg Lys Phe Phe Val Phe Thr Phe Leu Gly Ser 
    930                 935                 940                 


Ile Met Trp Ile Ala Met Phe Ser Tyr Leu Met Val Trp Trp Ala His 
945                 950                 955                 960 


Gln Val Gly Glu Thr Ile Gly Ile Ser Glu Glu Ile Met Gly Leu Thr 
                965                 970                 975     


Ile Leu Ala Ala Gly Thr Ser Ile Pro Asp Leu Ile Thr Ser Val Ile 
            980                 985                 990         


Val Ala Arg Lys Gly Leu Gly Asp  Met Ala Val Ser Ser  Ser Val Gly 
        995                 1000                 1005             


Ser Asn  Ile Phe Asp Ile Thr  Val Gly Leu Pro Val  Pro Trp Leu 
    1010                 1015                 1020             


Leu Phe  Ser Leu Ile Asn Gly  Leu Gln Pro Val Pro  Val Ser Ser 
    1025                 1030                 1035             


Asn Gly  Leu Phe Cys Ala Ile  Val Leu Leu Phe Leu  Met Leu Leu 
    1040                 1045                 1050             


Phe Val  Ile Ser Ser Ile Ala  Ser Cys Lys Trp Arg  Met Asn Lys 
    1055                 1060                 1065             


Ile Leu  Gly Phe Thr Met Phe  Leu Leu Tyr Phe Val  Phe Leu Ile 
    1070                 1075                 1080             


Ile Ser  Val Met Leu Glu Asp  Arg Ile Ile Ser Cys  Pro Val Ser 
    1085                 1090                 1095             


Val 
    


<210>  3310
<211>  6585
<212>  DNA
<213>  Homosapiens

<400>  3310
ggagaaagag gcggaggcag tggcggccgc gaggggaggg ggagtcccgt ctgactgaga     60

cggcaggcct gggcgggcgg gcgggggtgc cgcgaagggc ggagcgccgg gctggggatg    120

agctaagcgg gctcagagcg ccgcggcatt cagcccctcg tgttccgcta ccgcgcgtgc    180

gggattccgg cgccgctctc cgagctcgat ccgctgctcg cacgggagcc agctgggtgt    240

tatttctcaa actctgaggc tgcggagttc acacattgaa atctgtcatc tttttcagag    300

agaaactttc ggtaatgtat gtaaccttct gtaatggaag atgattgaag acaaggggcc    360

tcgtgttgct gactactttg ttgtagcagg attaactgat gtttcaaagc ctctagaaga    420

agaaattcac ttcaatgatg cttgtcataa agtagctaaa ccaaaagaac ctattacaga    480

tgtttcagtt attatcaaat ctcttgggga ggaagtccca caggattata tctgtattga    540

tgttacccca actggattgt cagctgatct taataatgga agtcttgtgg ggccacagat    600

ttacctttgc tatagaagag gaagagataa gcctccactt acagatctgg gggttttata    660

tgactggaaa gaaagattga aacagggttg tgaaattatt cagagtactc cctatgggcg    720

ccccgcaaat attagtggga gtacctcatc acaaagaatt tatatcactt accgaagagc    780

ctctgaaaac atgactcaga atacgttggc tgtcactgac atatgtatta ttatacccag    840

taaaggagaa agcccaccac acacgttctg caaagtcgac aagaatctca ataacagtat    900

gtggggatca gcagtatact tgtgttataa aaaatcggtg gcaaagacga acactgtatc    960

ttacaaagct ggcctaattt gtagatatcc tcaagaagat tatgagtcat tctcactacc   1020

ggaatctgtt cctctatttt gtttaccaat gggtgcaacc attgaatgtt ggccatcaaa   1080

tagcaaatac cctctgcctg tattttctac ttttgtttta actggagcct cagctgaaaa   1140

ggtttatggt gctgctattc agttttatga accatactct gaggagaatc tcacagaaaa   1200

gcagagactt cttttgggtt taacatcagc agatgggaag tctgatagtt ccaaaacaat   1260

tcatactaac aaatgcatct gtcttctttc tcactggcct ttttttgatg cattcaggaa   1320

gtttctgact tttctgtatc gttattccat ctctgggcct catgtccttc caattgagaa   1380

gcatatttct cattttatgc ataaagttcc ttttccatct cctcagagac cacggatttt   1440

agttcagtta tcaccacatg ataatctgat tctcagtcag cctgtgtctt cacctcttcc   1500

actaagtggt ggcaagtttt caacactact gcagaattta ggccctgaaa atgctgtgac   1560

actactggtg tttgcagtaa cagaacataa aattcttatc cattccctac ggccatccgt   1620

gcttactagt gtgacagaag cattagtgtc tatgattttc cctttccact ggccatgccc   1680

gtatgttcct ctctgcccac tggctttagc agatgtcttg agtgcaccat gtccattcat   1740

agtagggatt gattcaagat actttgatct ctatgatcct ccaccagatg tcagttgtgt   1800

tgatgtagat accaacacta tttctcagat tggtgacaag aaaaatgtag cctggaagat   1860

acttccaaag aagccatgta aaaatctgat gaacacactg aataatttgc atcagcaatt   1920

ggcaaaattg cagcagagac cgagagatga tggactcatg gatttagcaa taaatgacta   1980

tgattttaat tctggaaaga ggttgcacat gatagatttg gaaatccaag aggcattttt   2040

gtttttcatg gcctctattt taaaaggtta cagatcatac ttaaggccaa taacacaagc   2100

cccatctgag acagccacag atgcagcctc tctctttgcc ctacaagctt tcttaagaag   2160

ccgggaccgg tcacatcaaa aattctataa catgatgacc aaaacacaaa tgtttattcg   2220

cttcattgaa gaatgttctt ttgttagtga caaagatgca agcctggcat tttttgatga   2280

ttgtgtagat aaagtggata tggacaagag cggtgaagta cgacttatag aactggatga   2340

atctttcaaa agtgaacaca ctgtttttgt aacaccacct gagatccccc acctacccaa   2400

tggtgaagaa ccccctttac agtacagcta taatggattt ccagttctta ggaacaattt   2460

atttgaaaga cctgaaggat ttctacaagc aaagaagaac aaattgcctt caaaatcaag   2520

tagtcctaat agccctttgc ccatgttcag aagaacaaaa caggaaatta aatcagccca   2580

taaaattgca aagaggtact cttccatccc tcagatgtgg tctaggtgtc tactgcgcca   2640

ctgttatgga ctgtggttta tttgtctccc agcttatgtg aaagtctgtc attcaaaagt   2700

cagggctctg aaaacagcat atgatgtgct taaaaaaatg cagtcaaaga agatggatcc   2760

acctgatgag gtatgctacc gcattcttat gcaactctgt ggacaatatg atcagccagt   2820

gcttgcagtt cgagtgcttt ttgaaatgca gaaagctggt attgacccca atgccattac   2880

ttatggttat tataataagg ctgttttgga aagtacctgg ccttcaagaa gtcgtagtgg   2940

ctattttctt tggacaaaag taagaaatgt tgttttagga gtaacacagt tcaaaagagc   3000

tttaaagaag catgcacact tatcacaaac aactctctca ggtggccagt ctgatcttgg   3060

atataattca ttatctaaag atgaagttag aagaggggat acatctactg aagacattca   3120

agaagaaaaa gataaaaaag ggagtgattg tagttccttg tcagagagtg agagtacaaa   3180

aggaagtgct gattgccttc ctaagctcag ttatcaaaat tcttccagta tcgttcgcct   3240

cactggtaca agtaacaaca gtgctggtaa aatatcagga gaaagcatgg gtaaggaaag   3300

cacacctgag ctgctcttaa tatcatctct tgaagataca aatgaaacac gaaacattca   3360

aagtagatgc ttcaggaaaa gacataaaag tgacaatgaa actaatttgc agcagcaagt   3420

ggtctgggga aatagaaacc gtaatcttag tggaggggta ctgatgggat ttatgctcaa   3480

tagaattaac caggaagcaa cccctggaga tatagttgaa aaattgggag ctgatgcaaa   3540

aattctttca aatgttatct caaaaagcac gagaccaaat actcttgata ttgggaagcc   3600

acctttaaga tcaaaaagag acagtctaga aaaggaatct agtgatgatg atacaccttt   3660

tgatggttct aactatttgg cagataaagt ggattctcct gttatttttg acttagaaga   3720

cttagacagt gaaacagatg tatcaaaagc aggatgtgtt gctacacaaa atcccaagag   3780

gattcaacgt atgaacagca gcttttcagt aaaacctttt gaaaaaactg atgtcgcaac   3840

aggatttgat cccctctctc ttttggttgc tgagactgaa cagcagcaaa aagaagaaga   3900

ggaggaggat gaagatgata gcaaaagcat ttcaacacca tctgctaggc gtgatttagc   3960

tgaagaaatt gtgatgtata tgaataacat gagcagtcct ttgacaagtc gtacaccaag   4020

cattgattta caacgggcat gtgatgataa attaaataag aaaagtccac cattggtcaa   4080

ggcatgcaga agatctagtc tgcctcctaa ttctcctaag ccagtgagac ttaccaaatc   4140

taaaagttac acaaaaagtg aggagaaacc aagggataga ctttggtctt ctccagcctt   4200

ctcacctact tgcccattta gggaagaatc tcaggataca ttaacccact catcaccttc   4260

atttaactta gatacactac tagtacctaa actagatgtt ctaagaaaca gtatgttcac   4320

tgctggaaaa ggagttgcag agaaagcaag caaatggtat tcaagattca ccatgtacac   4380

cacatcatct aaggatcaaa gttctgatcg taccagtctt tcttcagtgg gagcccagga   4440

ttctgaatct acctctttaa cagatgaaga tgtctgccat gagttggaag gacctatctc   4500

ctctcaagag accagtgcta cttcagggac taagagaatt gatctcagcc gaataagcct   4560

ggaaagttct gcatccttgg aaggatctct gtcgaagttt gccttacctg ggaaatcaga   4620

agtgacatct tccttcaacg cgagtaatac aaatatcttc cagaactatg caatggaggt   4680

tctcatctca agttgctctc ggtgtagaac ttgtgattgt cttgtccatg atgaggaaat   4740

catggctggc tggacagcag atgattcaaa tctcaatact acatgcccat tctgtggcaa   4800

tatcttctta ccctttctga atatagaaat aagagattta agacgacctg gaagatactt   4860

tctaaagtca agcccatcaa cagaaaatat gcactttcca tcctccattt caagtcagac   4920

gaggcagtct tgcatttcaa catcagcctc tggtcttgac acatctgctc tctctgttca   4980

agggaatttt gatctaaata gcaaatctaa actgcaggaa aatttttgca cccgaagtat   5040

tcagatccct gctaatagat caaaaacagc tatgtctaaa tgtccaatat ttccaatggc   5100

caggagtatt agtacttctg gccccttgga taaggaagat actggaagac agaagctcat   5160

ttctacaggc agcctgccag ctactttaca aggagctaca gattctttag gtttagaatg   5220

gcaccttcca agtcccgatc ctgtcactgt tccgtatctt agtcctttag tggtatggaa   5280

agaacttgaa agcttattgg aaaatgaagg tgatcatgca ataacagtag cagactttgt   5340

ggaccatcat ccaattgttt tttggaacct ggtatggtat ttcagacgtc ttgacttgcc   5400

cagtaactta cctggattga ttctttcttc tgagcactgt aacaagtatt caaagattcc   5460

ccgccactgt atgtctgaag atagcaaata tgttttaata caaatgttat gggacaatat   5520

gaagttacat caggatccgg gacagccctt gtacattctc tggaatgcac acacccaaaa   5580

atatccaatg gtccatttat tgcaaaaaag tgataactca tttaaccagg aactgttgaa   5640

aagtatggta aaaagcatta aaatgaatga tgtctatgga ccaatgagtc agattttaga   5700

gacactgaat aagtgtccac attttaaaag acagaggagt ttatacagag aaatactatt   5760

tctctcactt gtggcactgg gaagagaaaa cattgatata gatgcttttg ataaagagta   5820

caagatggca tacgatcgtc tcacacctag tcaagtcaag agtacacaca actgtgatag   5880

accaccaagt acaggggtga tggaatgtcg aaaaaccttt ggagaacctt atctttaaga   5940

tgtatttgta tgtgtaaaca ttcaatgtat attgtatagt cagtgtataa aataacactt   6000

ttagactcta aatatttttt cttcaatttt tgaaaataca atttgtaaat ggttcaaaag   6060

actcagacag cttatgtaca gaatgtttga agaagagaat agtgacaagt ggggagaaag   6120

ccactttgtt tctcatttct tttttcttct tctttaactc ccctgtaata ggaaataaag   6180

tatttttgtg atgaggaaat ccctaaacaa aattagttgc cataaaatat gacaactgct   6240

ttatggtttc ttttggaaga gacagattga aaaatcatga atggaatcta aacagaaatg   6300

tcagatgaac gtatttcctg ttttcataga ctattcaaat gttttgacca tgaagttgta   6360

ttatacatat tttaaattgt ttatagtaag ttgatatttt tttaattttt aaatttaata   6420

tagcaaactt aaaatgaatt taaacttaag caagcaagcg tgtattttcc ttgtctgctg   6480

ctatttgaag taattagtac agctgcagat ctctctgtgt atatctatct atatatatat   6540

tttttattac ttgggagaat gaattttaaa atgtcagtgc tagtg                   6585


<210>  3311
<211>  1865
<212>  PRT
<213>  Homosapiens

<400>  3311

Met Ile Glu Asp Lys Gly Pro Arg Val Ala Asp Tyr Phe Val Val Ala 
1               5                   10                  15      


Gly Leu Thr Asp Val Ser Lys Pro Leu Glu Glu Glu Ile His Phe Asn 
            20                  25                  30          


Asp Ala Cys His Lys Val Ala Lys Pro Lys Glu Pro Ile Thr Asp Val 
        35                  40                  45              


Ser Val Ile Ile Lys Ser Leu Gly Glu Glu Val Pro Gln Asp Tyr Ile 
    50                  55                  60                  


Cys Ile Asp Val Thr Pro Thr Gly Leu Ser Ala Asp Leu Asn Asn Gly 
65                  70                  75                  80  


Ser Leu Val Gly Pro Gln Ile Tyr Leu Cys Tyr Arg Arg Gly Arg Asp 
                85                  90                  95      


Lys Pro Pro Leu Thr Asp Leu Gly Val Leu Tyr Asp Trp Lys Glu Arg 
            100                 105                 110         


Leu Lys Gln Gly Cys Glu Ile Ile Gln Ser Thr Pro Tyr Gly Arg Pro 
        115                 120                 125             


Ala Asn Ile Ser Gly Ser Thr Ser Ser Gln Arg Ile Tyr Ile Thr Tyr 
    130                 135                 140                 


Arg Arg Ala Ser Glu Asn Met Thr Gln Asn Thr Leu Ala Val Thr Asp 
145                 150                 155                 160 


Ile Cys Ile Ile Ile Pro Ser Lys Gly Glu Ser Pro Pro His Thr Phe 
                165                 170                 175     


Cys Lys Val Asp Lys Asn Leu Asn Asn Ser Met Trp Gly Ser Ala Val 
            180                 185                 190         


Tyr Leu Cys Tyr Lys Lys Ser Val Ala Lys Thr Asn Thr Val Ser Tyr 
        195                 200                 205             


Lys Ala Gly Leu Ile Cys Arg Tyr Pro Gln Glu Asp Tyr Glu Ser Phe 
    210                 215                 220                 


Ser Leu Pro Glu Ser Val Pro Leu Phe Cys Leu Pro Met Gly Ala Thr 
225                 230                 235                 240 


Ile Glu Cys Trp Pro Ser Asn Ser Lys Tyr Pro Leu Pro Val Phe Ser 
                245                 250                 255     


Thr Phe Val Leu Thr Gly Ala Ser Ala Glu Lys Val Tyr Gly Ala Ala 
            260                 265                 270         


Ile Gln Phe Tyr Glu Pro Tyr Ser Glu Glu Asn Leu Thr Glu Lys Gln 
        275                 280                 285             


Arg Leu Leu Leu Gly Leu Thr Ser Ala Asp Gly Lys Ser Asp Ser Ser 
    290                 295                 300                 


Lys Thr Ile His Thr Asn Lys Cys Ile Cys Leu Leu Ser His Trp Pro 
305                 310                 315                 320 


Phe Phe Asp Ala Phe Arg Lys Phe Leu Thr Phe Leu Tyr Arg Tyr Ser 
                325                 330                 335     


Ile Ser Gly Pro His Val Leu Pro Ile Glu Lys His Ile Ser His Phe 
            340                 345                 350         


Met His Lys Val Pro Phe Pro Ser Pro Gln Arg Pro Arg Ile Leu Val 
        355                 360                 365             


Gln Leu Ser Pro His Asp Asn Leu Ile Leu Ser Gln Pro Val Ser Ser 
    370                 375                 380                 


Pro Leu Pro Leu Ser Gly Gly Lys Phe Ser Thr Leu Leu Gln Asn Leu 
385                 390                 395                 400 


Gly Pro Glu Asn Ala Val Thr Leu Leu Val Phe Ala Val Thr Glu His 
                405                 410                 415     


Lys Ile Leu Ile His Ser Leu Arg Pro Ser Val Leu Thr Ser Val Thr 
            420                 425                 430         


Glu Ala Leu Val Ser Met Ile Phe Pro Phe His Trp Pro Cys Pro Tyr 
        435                 440                 445             


Val Pro Leu Cys Pro Leu Ala Leu Ala Asp Val Leu Ser Ala Pro Cys 
    450                 455                 460                 


Pro Phe Ile Val Gly Ile Asp Ser Arg Tyr Phe Asp Leu Tyr Asp Pro 
465                 470                 475                 480 


Pro Pro Asp Val Ser Cys Val Asp Val Asp Thr Asn Thr Ile Ser Gln 
                485                 490                 495     


Ile Gly Asp Lys Lys Asn Val Ala Trp Lys Ile Leu Pro Lys Lys Pro 
            500                 505                 510         


Cys Lys Asn Leu Met Asn Thr Leu Asn Asn Leu His Gln Gln Leu Ala 
        515                 520                 525             


Lys Leu Gln Gln Arg Pro Arg Asp Asp Gly Leu Met Asp Leu Ala Ile 
    530                 535                 540                 


Asn Asp Tyr Asp Phe Asn Ser Gly Lys Arg Leu His Met Ile Asp Leu 
545                 550                 555                 560 


Glu Ile Gln Glu Ala Phe Leu Phe Phe Met Ala Ser Ile Leu Lys Gly 
                565                 570                 575     


Tyr Arg Ser Tyr Leu Arg Pro Ile Thr Gln Ala Pro Ser Glu Thr Ala 
            580                 585                 590         


Thr Asp Ala Ala Ser Leu Phe Ala Leu Gln Ala Phe Leu Arg Ser Arg 
        595                 600                 605             


Asp Arg Ser His Gln Lys Phe Tyr Asn Met Met Thr Lys Thr Gln Met 
    610                 615                 620                 


Phe Ile Arg Phe Ile Glu Glu Cys Ser Phe Val Ser Asp Lys Asp Ala 
625                 630                 635                 640 


Ser Leu Ala Phe Phe Asp Asp Cys Val Asp Lys Val Asp Met Asp Lys 
                645                 650                 655     


Ser Gly Glu Val Arg Leu Ile Glu Leu Asp Glu Ser Phe Lys Ser Glu 
            660                 665                 670         


His Thr Val Phe Val Thr Pro Pro Glu Ile Pro His Leu Pro Asn Gly 
        675                 680                 685             


Glu Glu Pro Pro Leu Gln Tyr Ser Tyr Asn Gly Phe Pro Val Leu Arg 
    690                 695                 700                 


Asn Asn Leu Phe Glu Arg Pro Glu Gly Phe Leu Gln Ala Lys Lys Asn 
705                 710                 715                 720 


Lys Leu Pro Ser Lys Ser Ser Ser Pro Asn Ser Pro Leu Pro Met Phe 
                725                 730                 735     


Arg Arg Thr Lys Gln Glu Ile Lys Ser Ala His Lys Ile Ala Lys Arg 
            740                 745                 750         


Tyr Ser Ser Ile Pro Gln Met Trp Ser Arg Cys Leu Leu Arg His Cys 
        755                 760                 765             


Tyr Gly Leu Trp Phe Ile Cys Leu Pro Ala Tyr Val Lys Val Cys His 
    770                 775                 780                 


Ser Lys Val Arg Ala Leu Lys Thr Ala Tyr Asp Val Leu Lys Lys Met 
785                 790                 795                 800 


Gln Ser Lys Lys Met Asp Pro Pro Asp Glu Val Cys Tyr Arg Ile Leu 
                805                 810                 815     


Met Gln Leu Cys Gly Gln Tyr Asp Gln Pro Val Leu Ala Val Arg Val 
            820                 825                 830         


Leu Phe Glu Met Gln Lys Ala Gly Ile Asp Pro Asn Ala Ile Thr Tyr 
        835                 840                 845             


Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Thr Trp Pro Ser Arg Ser 
    850                 855                 860                 


Arg Ser Gly Tyr Phe Leu Trp Thr Lys Val Arg Asn Val Val Leu Gly 
865                 870                 875                 880 


Val Thr Gln Phe Lys Arg Ala Leu Lys Lys His Ala His Leu Ser Gln 
                885                 890                 895     


Thr Thr Leu Ser Gly Gly Gln Ser Asp Leu Gly Tyr Asn Ser Leu Ser 
            900                 905                 910         


Lys Asp Glu Val Arg Arg Gly Asp Thr Ser Thr Glu Asp Ile Gln Glu 
        915                 920                 925             


Glu Lys Asp Lys Lys Gly Ser Asp Cys Ser Ser Leu Ser Glu Ser Glu 
    930                 935                 940                 


Ser Thr Lys Gly Ser Ala Asp Cys Leu Pro Lys Leu Ser Tyr Gln Asn 
945                 950                 955                 960 


Ser Ser Ser Ile Val Arg Leu Thr Gly Thr Ser Asn Asn Ser Ala Gly 
                965                 970                 975     


Lys Ile Ser Gly Glu Ser Met Gly Lys Glu Ser Thr Pro Glu Leu Leu 
            980                 985                 990         


Leu Ile Ser Ser Leu Glu Asp Thr  Asn Glu Thr Arg Asn  Ile Gln Ser 
        995                 1000                 1005             


Arg Cys  Phe Arg Lys Arg His  Lys Ser Asp Asn Glu  Thr Asn Leu 
    1010                 1015                 1020             


Gln Gln  Gln Val Val Trp Gly  Asn Arg Asn Arg Asn  Leu Ser Gly 
    1025                 1030                 1035             


Gly Val  Leu Met Gly Phe Met  Leu Asn Arg Ile Asn  Gln Glu Ala 
    1040                 1045                 1050             


Thr Pro  Gly Asp Ile Val Glu  Lys Leu Gly Ala Asp  Ala Lys Ile 
    1055                 1060                 1065             


Leu Ser  Asn Val Ile Ser Lys  Ser Thr Arg Pro Asn  Thr Leu Asp 
    1070                 1075                 1080             


Ile Gly  Lys Pro Pro Leu Arg  Ser Lys Arg Asp Ser  Leu Glu Lys 
    1085                 1090                 1095             


Glu Ser  Ser Asp Asp Asp Thr  Pro Phe Asp Gly Ser  Asn Tyr Leu 
    1100                 1105                 1110             


Ala Asp  Lys Val Asp Ser Pro  Val Ile Phe Asp Leu  Glu Asp Leu 
    1115                 1120                 1125             


Asp Ser  Glu Thr Asp Val Ser  Lys Ala Gly Cys Val  Ala Thr Gln 
    1130                 1135                 1140             


Asn Pro  Lys Arg Ile Gln Arg  Met Asn Ser Ser Phe  Ser Val Lys 
    1145                 1150                 1155             


Pro Phe  Glu Lys Thr Asp Val  Ala Thr Gly Phe Asp  Pro Leu Ser 
    1160                 1165                 1170             


Leu Leu  Val Ala Glu Thr Glu  Gln Gln Gln Lys Glu  Glu Glu Glu 
    1175                 1180                 1185             


Glu Asp  Glu Asp Asp Ser Lys  Ser Ile Ser Thr Pro  Ser Ala Arg 
    1190                 1195                 1200             


Arg Asp  Leu Ala Glu Glu Ile  Val Met Tyr Met Asn  Asn Met Ser 
    1205                 1210                 1215             


Ser Pro  Leu Thr Ser Arg Thr  Pro Ser Ile Asp Leu  Gln Arg Ala 
    1220                 1225                 1230             


Cys Asp  Asp Lys Leu Asn Lys  Lys Ser Pro Pro Leu  Val Lys Ala 
    1235                 1240                 1245             


Cys Arg  Arg Ser Ser Leu Pro  Pro Asn Ser Pro Lys  Pro Val Arg 
    1250                 1255                 1260             


Leu Thr  Lys Ser Lys Ser Tyr  Thr Lys Ser Glu Glu  Lys Pro Arg 
    1265                 1270                 1275             


Asp Arg  Leu Trp Ser Ser Pro  Ala Phe Ser Pro Thr  Cys Pro Phe 
    1280                 1285                 1290             


Arg Glu  Glu Ser Gln Asp Thr  Leu Thr His Ser Ser  Pro Ser Phe 
    1295                 1300                 1305             


Asn Leu  Asp Thr Leu Leu Val  Pro Lys Leu Asp Val  Leu Arg Asn 
    1310                 1315                 1320             


Ser Met  Phe Thr Ala Gly Lys  Gly Val Ala Glu Lys  Ala Ser Lys 
    1325                 1330                 1335             


Trp Tyr  Ser Arg Phe Thr Met  Tyr Thr Thr Ser Ser  Lys Asp Gln 
    1340                 1345                 1350             


Ser Ser  Asp Arg Thr Ser Leu  Ser Ser Val Gly Ala  Gln Asp Ser 
    1355                 1360                 1365             


Glu Ser  Thr Ser Leu Thr Asp  Glu Asp Val Cys His  Glu Leu Glu 
    1370                 1375                 1380             


Gly Pro  Ile Ser Ser Gln Glu  Thr Ser Ala Thr Ser  Gly Thr Lys 
    1385                 1390                 1395             


Arg Ile  Asp Leu Ser Arg Ile  Ser Leu Glu Ser Ser  Ala Ser Leu 
    1400                 1405                 1410             


Glu Gly  Ser Leu Ser Lys Phe  Ala Leu Pro Gly Lys  Ser Glu Val 
    1415                 1420                 1425             


Thr Ser  Ser Phe Asn Ala Ser  Asn Thr Asn Ile Phe  Gln Asn Tyr 
    1430                 1435                 1440             


Ala Met  Glu Val Leu Ile Ser  Ser Cys Ser Arg Cys  Arg Thr Cys 
    1445                 1450                 1455             


Asp Cys  Leu Val His Asp Glu  Glu Ile Met Ala Gly  Trp Thr Ala 
    1460                 1465                 1470             


Asp Asp  Ser Asn Leu Asn Thr  Thr Cys Pro Phe Cys  Gly Asn Ile 
    1475                 1480                 1485             


Phe Leu  Pro Phe Leu Asn Ile  Glu Ile Arg Asp Leu  Arg Arg Pro 
    1490                 1495                 1500             


Gly Arg  Tyr Phe Leu Lys Ser  Ser Pro Ser Thr Glu  Asn Met His 
    1505                 1510                 1515             


Phe Pro  Ser Ser Ile Ser Ser  Gln Thr Arg Gln Ser  Cys Ile Ser 
    1520                 1525                 1530             


Thr Ser  Ala Ser Gly Leu Asp  Thr Ser Ala Leu Ser  Val Gln Gly 
    1535                 1540                 1545             


Asn Phe  Asp Leu Asn Ser Lys  Ser Lys Leu Gln Glu  Asn Phe Cys 
    1550                 1555                 1560             


Thr Arg  Ser Ile Gln Ile Pro  Ala Asn Arg Ser Lys  Thr Ala Met 
    1565                 1570                 1575             


Ser Lys  Cys Pro Ile Phe Pro  Met Ala Arg Ser Ile  Ser Thr Ser 
    1580                 1585                 1590             


Gly Pro  Leu Asp Lys Glu Asp  Thr Gly Arg Gln Lys  Leu Ile Ser 
    1595                 1600                 1605             


Thr Gly  Ser Leu Pro Ala Thr  Leu Gln Gly Ala Thr  Asp Ser Leu 
    1610                 1615                 1620             


Gly Leu  Glu Trp His Leu Pro  Ser Pro Asp Pro Val  Thr Val Pro 
    1625                 1630                 1635             


Tyr Leu  Ser Pro Leu Val Val  Trp Lys Glu Leu Glu  Ser Leu Leu 
    1640                 1645                 1650             


Glu Asn  Glu Gly Asp His Ala  Ile Thr Val Ala Asp  Phe Val Asp 
    1655                 1660                 1665             


His His  Pro Ile Val Phe Trp  Asn Leu Val Trp Tyr  Phe Arg Arg 
    1670                 1675                 1680             


Leu Asp  Leu Pro Ser Asn Leu  Pro Gly Leu Ile Leu  Ser Ser Glu 
    1685                 1690                 1695             


His Cys  Asn Lys Tyr Ser Lys  Ile Pro Arg His Cys  Met Ser Glu 
    1700                 1705                 1710             


Asp Ser  Lys Tyr Val Leu Ile  Gln Met Leu Trp Asp  Asn Met Lys 
    1715                 1720                 1725             


Leu His  Gln Asp Pro Gly Gln  Pro Leu Tyr Ile Leu  Trp Asn Ala 
    1730                 1735                 1740             


His Thr  Gln Lys Tyr Pro Met  Val His Leu Leu Gln  Lys Ser Asp 
    1745                 1750                 1755             


Asn Ser  Phe Asn Gln Glu Leu  Leu Lys Ser Met Val  Lys Ser Ile 
    1760                 1765                 1770             


Lys Met  Asn Asp Val Tyr Gly  Pro Met Ser Gln Ile  Leu Glu Thr 
    1775                 1780                 1785             


Leu Asn  Lys Cys Pro His Phe  Lys Arg Gln Arg Ser  Leu Tyr Arg 
    1790                 1795                 1800             


Glu Ile  Leu Phe Leu Ser Leu  Val Ala Leu Gly Arg  Glu Asn Ile 
    1805                 1810                 1815             


Asp Ile  Asp Ala Phe Asp Lys  Glu Tyr Lys Met Ala  Tyr Asp Arg 
    1820                 1825                 1830             


Leu Thr  Pro Ser Gln Val Lys  Ser Thr His Asn Cys  Asp Arg Pro 
    1835                 1840                 1845             


Pro Ser  Thr Gly Val Met Glu  Cys Arg Lys Thr Phe  Gly Glu Pro 
    1850                 1855                 1860             


Tyr Leu  
    1865 


<210>  3312
<211>  2393
<212>  DNA
<213>  Homosapiens

<400>  3312
agcggcaggg aggggctctt cacccagtcc ggcagttgaa gctcggcgct cgggttaccc     60

ctgcagcgac gccccctggt cccacagata ccactgctgc tcccgccctt tcgctcctcg    120

gccgcgcaat gggcacccgc gacgacgagt acgactacct ctttaaagtt gtccttattg    180

gagattctgg tgttggaaag agtaatctcc tgtctcgatt tactcgaaat gagtttaatc    240

tggaaagcaa gagcaccatt ggagtagagt ttgcaacaag aagcatccag gttgatggaa    300

aaacaataaa ggcacagata tgggacacag cagggcaaga gcgatatcga gctataacat    360

cagcatatta tcgtggagct gtaggtgcct tattggttta tgacattgct aaacatctca    420

catatgaaaa tgtagagcga tggctgaaag aactgagaga tcatgctgat agtaacattg    480

ttatcatgct tgtgggcaat aagagtgatc tacgtcatct cagggcagtt cctacagatg    540

aagcaagagc ttttgcagaa aagaatggtt tgtcattcat tgaaacttcg gccctagact    600

ctacaaatgt agaagctgct tttcagacaa ttttaacaga gatttaccgc attgtttctc    660

agaagcaaat gtcagacaga cgcgaaaatg acatgtctcc aagcaacaat gtggttccta    720

ttcatgttcc accaaccact gaaaacaagc caaaggtgca gtgctgtcag aacatctaag    780

gcatttctct tctcccctag aaggctgtgt atagtccatt tcccaggtct gagatttaaa    840

tatatttgta attcttgtgt cacttttgtg ttttattact tcatacttat gaatttttcc    900

atgtcctaag tcttttgatt ttagctttat aaaatcatcc acttgtcccg aatgactgca    960

gctttttttc atgctatggc ttcactagcc ttagtttaat aaactgaatg tttggattcc   1020

tcagttattg tttacttttc atcatggaag cctgtcactg tatgtaggac ataatagaac   1080

ttgatcactt gaagctcaga cctattggtc ttgatcaaat caaactaaga agaccttaga   1140

aataagctac cattttgcca cagagcagct tataggtaat acactcttct ctcagtgcag   1200

tgtacatttc cacaaatcta agaattgccc tataaacata gcaggatttt gagagcttga   1260

aaattttcca ttattctgga catgaatttc taaaatgcct taataggttt atgtagttga   1320

gtaaattttg ttttttaatt tttgtaagca tcaaagttga ttagagaggg gggcactttt   1380

tctggagaat tctcttagta aacacaaaag attgttacgg tttcattagt agtatggttg   1440

tggggccata agttaaacag tgctgcctgg taggctggga actgaagaga cttgtggtat   1500

tccatctcgg gtgcctctgt tggcaatgat caggcagccc aaaagattta aatgatctat   1560

aataatttcc aagcggtaga ttatgtggca ttttattgct caggcaataa ttggtttaat   1620

gctggtagtg tcaaattttg aagtgttaat tttgtcttag aaccttccag taagtgaaat   1680

acaacctagt tttatcacca tatccaccag caggcatgga taattatttt aacaatgcta   1740

atatttgagt tttgcagtat attatagaat atagtccagt taaatctttg gtttcagtat   1800

gtctgaagag tacagtgaga ggttaatttc tgctcaagtg gtaccactta aaggcatgta   1860

ttcttttagt atgtaaaatg aaatagtacc ttgagtttaa atagaatgca tttaggcatt   1920

gtagagatct gaaatagttt tcttccacta cattgttgaa atcaatgaag caattagttt   1980

ctcattcaga aatgtgcaca ctaatattta gttttgcttt ctcgtggata atattaagca   2040

cttactctgc agtttcctgg aagttgtgtc aactgcagtg atactattca ggatggtggg   2100

aaatccccaa aaatatgtat gtgtgggctt gcttagatta ctatatttca tagttaatct   2160

tttgtctctt gcggtgctca tgatgtgtgg ggcacacgga aggcattgct gtagtcagtc   2220

attttggttt tcttctatag ccattttatt attttagtgt attagttatg aagataatat   2280

tatctatttg taaattgcta ctttgtattt tatgcatgct ctgtaatttg attttttttt   2340

agttattgat ttggattata ttcacattct aataaacagt tataggggga tta          2393


<210>  3313
<211>  216
<212>  PRT
<213>  Homosapiens

<400>  3313

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
1               5                   10                  15      


Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
            20                  25                  30          


Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
        35                  40                  45              


Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
    50                  55                  60                  


Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
65                  70                  75                  80  


Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                85                  90                  95      


Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
            100                 105                 110         


Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
        115                 120                 125             


Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
    130                 135                 140                 


Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
145                 150                 155                 160 


Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                165                 170                 175     


Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
            180                 185                 190         


Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
        195                 200                 205             


Lys Val Gln Cys Cys Gln Asn Ile 
    210                 215     


<210>  3314
<211>  5702
<212>  DNA
<213>  Homosapiens

<400>  3314
gcccgctgcc cgccgcccgg ctcccggctg ctcgcggccc cctgctcctg cctggcgctc     60

tggccaggct cgggctccgg aggacaggac cgcgcgactg gccggccgat ccctgggccg    120

gccgcgggag cagctatgct gtgactgtcc aggaatcgta tgcacacccc ttcgatcaga    180

tctattacac acgatgcaca gacatcctca actggttcaa gtgcaccagg caccgccctg    240

tgtacggagg agtgtgtgca cggccgctgc gtttccccgg acacctgcca ctgcgagcct    300

ggctggggag ggcccgactg ctccagcggc tgcgacagcg accactgggg gccccactgc    360

agcaaccggt gccagtgcca gaacggcgcc ctgtgtaacc ccatcacagg cgcctgcgtg    420

tgcgccgccg gcttccgtgg atggcgctgc gaggagctct gcgcgcctgg cacccacggc    480

aagggatgcc agctgccgtg ccagtgccga cacggtgcca gctgcgaccc ccgcgccggc    540

gagtgcctct gcgcacctgg ctacaccggc gtctactgcg aggagctgtg ccctcctggg    600

agccatggag ctcactgtga gctgcgctgc ccctgtcaga atgggggcac ctgccaccac    660

atcactggcg agtgtgcctg ccccccaggc tggacgggag cagtgtgtgc ccagccctgc    720

ccaccaggga catttggcca gaactgcagc caggattgtc cttgccacca tggagggcag    780

tgtgaccacg tgactggaca gtgccactgt acagctggat acatggggga caggtgccaa    840

gaggagtgcc ccttcgggtc cttcggcttc cagtgctcac agcgctgtga ctgccacaat    900

ggggggcagt gttcacccac cacgggtgcc tgcgagtgtg agcctggcta caagggccca    960

cgctgccagg agcgactgtg cccggagggc ctgcatggcc caggctgcac cctgccctgc   1020

ccctgtgacg ctgacaacac catcagctgc cacccagtaa ctggagcttg tacctgccag   1080

ccaggctggt ctggtcacca ctgcaatgaa tcctgccctg ttggctacta tggcgatggc   1140

tgccagctgc cttgcacctg tcagaatggc gccgactgcc acagcatcac tgggggctgc   1200

acttgtgctc cgggcttcat gggagaggtc tgtgccgttt cctgtgcagc agggacctat   1260

ggccccaact gctcgtccat ctgtagctgt aacaatggtg gcacctgctc cccagtagat   1320

ggctcctgta cctgcaagga agggtggcag ggcctggact gcaccctgcc atgtcccagt   1380

gggacgtggg gcctgaactg caacgagagc tgcacctgtg ccaatggggc agcctgcagc   1440

cccatagacg gctcctgctc ctgcactcct ggctggctgg gagacacctg tgagctgcct   1500

tgcccggatg gcacatttgg gctgaactgc agtgaacact gtgactgcag ccatgctgat   1560

ggatgtgacc ccgtcacagg ccactgctgc tgcctggccg gatggacagg catccgctgt   1620

gacagcacgt gtccacctgg ccgctggggc cccaactgct ctgtctcctg cagctgtgag   1680

aatggaggct cctgctcccc agaggatggg agctgcgagt gtgcccctgg cttccgagga   1740

cccttatgcc agagaatctg cccccctggg ttctatggcc acggctgcgc ccagccatgc   1800

cccctctgcg tgcacagcag caggccctgc caccacatca gcggcatctg tgagtgcctc   1860

ccaggattct ctggagctct ctgcaaccaa gtgtgtgctg gaggatactt tgggcaggac   1920

tgtgcccagc tctgctcctg tgccaacaac gggacctgca gccctatcga tggctcctgc   1980

cagtgctttc ctggatggat tggcaaggac tgctcacagg cttgcccacc cgggttctgg   2040

ggccccgcct gcttccacgc atgcagctgc cacaacgggg cgagctgcag cgccgaggac   2100

ggggcctgcc actgcacccc tggctggact ggactcttct gcacacagcg ctgcccagca   2160

gcattttttg ggaaggactg tgggcgcgta tgccagtgtc agaatggcgc cagctgtgac   2220

cacatcagtg gcaagtgcac ctgccgcaca ggcttcaccg ggcaacactg tgagcagaga   2280

tgtgccccag gaacctttgg ctatgggtgt cagcagctat gtgagtgcat gaacaactcc   2340

acctgtgacc atgtcaccgg cacctgttac tgcagccctg gcttcaaagg aatcaggtgt   2400

gaccaagctg ccctcatgat ggaggagctg aatccctaca ccaagatcag cccagcactg   2460

ggtgcagagc ggcactcggt gggtgctgtc acaggcatca tgctcctgtt attcttcatt   2520

gtggtgctgc tgggcctatt tgcctggcat cggcggcggc agaaagagaa gggccgagac   2580

ctggctcccc gtgtctccta cacacctgcc atgaggatga ccagcaccga ctactccctc   2640

tcaggtgctt gtggaatgga tagacgtcag aacacataca ttatggacaa aggcttcaaa   2700

gattacatga aagaatccgt gtgcagttct agtacttgtt ccttgaatag cagtgaaaac   2760

ccttacgcca caattaagga cccacccatc ctcacctgca agcttccaga aagcagctat   2820

gtagaaatga agtcgcctgt gcacatgggg tctccgtaca cagatgtgcc atccttgtcg   2880

acatctaata aaaatatata tgaagttgag cccacagtca gtgtggtcca agaaggttgc   2940

ggtcataact ccagctatat ccagaatgca tacgacctac ctaggaacag ccatattcct   3000

ggtcattatg acctcctccc agtaagacag agccctgcca atgggccgtc ccaggacaag   3060

caatcttaag agggataagc ttctctcttg cagtgtgctc tactgaatat tctgactctg   3120

aaagaagaca gtcccttgac ttgaagtaat ggtacagact ggctccagct gcatgttagt   3180

tattacgttc acctggaact aaagaagagc gtccaggtgg gactgggata attgttcaag   3240

gaattgtgtt ctcaaaggca aatcctatca cccactcagc cccaaatgcc ctggattata   3300

tgatttttaa aacattttaa gatacagcta ctcatcaaca tcagctaaat atagctgata   3360

tatatatata tatttatctg aaacgtgata ttttaaaaac atgtaggttt aacaaacctt   3420

cctaggacaa aaaggagact ggggagggaa gaggattact ttaaagcacc tgaaacgtat   3480

atgtactttt ggttgctgtt accatcaaca tctgttttat taccgaagac aattagtaca   3540

cagacatgaa ctgttcttaa acagaacagt cttaaaatgt ctgtacatat ctgtctggtc   3600

catcaaatta caacagccaa gattacagaa tctatatagt ctaatgctga caacttctat   3660

tttaaaaaac aagactttac tttcttctgc cccctaagtg ataggtttaa acacacagag   3720

acacacacac acgtttccaa agtgcagcag tgtctctttc agtctacaat aagattccta   3780

gggcagcttt atcaaatttt gccaattcaa agttcaagga cattacaagt tagtcctggc   3840

tttgtcatat ctacttagtc catccgacac ctgaatcatt ccatgtaaaa cagagctcta   3900

agatgatcct ttaagcaagc agtcatagac tggtcgggat taagtaaaag acggctagtt   3960

ggcctcctca ttttatttgg tcagcatccc ttgactcaag agtacttgct ttcaagttct   4020

tcataaatct tgagattgac gtagtatgaa acctaaaagt atacaggaaa ttggacaaat   4080

gtggatacag caagtttaca ctgcttaaag tacattatgc tttttaatgg aactaaatga   4140

tcaaaaaaag aatggactgt aaccagttgc tgtaacatga tgtaaaaacg ttactgtaaa   4200

cagcatgagg atatgaagtc cttccacctt ctatcttaaa actactactt actgagctag   4260

cccaatatgc attacaatga gctaatgctc cagatcccag tattcagatg tgtctatacc   4320

ttccactatg aacacagata aactgaggct cagataagtc caaatgaaat gaaatcaact   4380

cccaagccct aaagagaacc ttctcacaag aattaaaaac aaaaagggca aacctaggaa   4440

gctaacggct actcctgtac cactctattc actggtacag tccagccagt aaaaaacact   4500

tccaaaaaga tacacagaag aggaactaaa tgactgcgaa gctggaatac tgctacagga   4560

agtatgagag ttctgaaacc cttgatagaa actggaagcc tgccatggaa cacaatactt   4620

tgggcaataa tcagaaaaag caaaaaaata aataaatgag tacatctccc cttcccacat   4680

cactcaaggc ataagcagat tttactgtta gaggaaaata tgtaatactt acatgaatgt   4740

tgcatgtgtg catgggagca actgagtagc aatagtaaat ttactttcca aaaaagcctt   4800

attaaaatat aaatattaga aaattacttt ggagacccaa gtaaatattt ctcatacata   4860

tgtagaaaga aatataggta agcagcttac ctcagtattt cagggcagca agtgtttgtg   4920

aagcaaggat gagcagcatg aagatgtcag atcagcaagg agaaacttca actcaatccc   4980

aggttttctc ttcttccctt atcctgcatg tacaataact gctgcctggc aaactgcaaa   5040

caagcagcat cactcaagtt tgaagtttcg ccgcttttgt caactatcct ctgggcaaag   5100

gtattcagca agaggtggaa tggctagaca ctgaatcaag agatttcagt gttactctgg   5160

tcaagttagt cgccctctct gggctccctt tttttctatg cataaaaagg ggagaagcag   5220

agagtgggaa gacagctcta ctaacccttc agctctagca gtccatgact ttttaaggaa   5280

atgtaataca agtcaaacca ggcaatacag aggagaaggg aaaggcagag ggtgtgatta   5340

tggtgacaat agctgccttc ccctatcgaa cagttatcag taaaagacat ttcaatctta   5400

caaagcaact gttagaaact tctgtctaac accatcacaa ataggttcat ggtcagccta   5460

aacatgtata ctgtgcattt tatgggtgac tttgaaagat ctgttcaatt atttttcaga   5520

aactaaattt tcaaaaaatt aatatgtgta caattaaaat gaatgaaaga aaaaccatta   5580

ttgtacagag gtattaatga gactatgaaa cggcaatact tttttaaatc acagatttgt   5640

aatatatgtt cactgtgcag agggattgta ccttgtacaa aataaaacaa atttctcaaa   5700

ct                                                                  5702


<210>  3315
<211>  969
<212>  PRT
<213>  Homosapiens

<400>  3315

Met His Thr Pro Ser Ile Arg Ser Ile Thr His Asp Ala Gln Thr Ser 
1               5                   10                  15      


Ser Thr Gly Ser Ser Ala Pro Gly Thr Ala Leu Cys Thr Glu Glu Cys 
            20                  25                  30          


Val His Gly Arg Cys Val Ser Pro Asp Thr Cys His Cys Glu Pro Gly 
        35                  40                  45              


Trp Gly Gly Pro Asp Cys Ser Ser Gly Cys Asp Ser Asp His Trp Gly 
    50                  55                  60                  


Pro His Cys Ser Asn Arg Cys Gln Cys Gln Asn Gly Ala Leu Cys Asn 
65                  70                  75                  80  


Pro Ile Thr Gly Ala Cys Val Cys Ala Ala Gly Phe Arg Gly Trp Arg 
                85                  90                  95      


Cys Glu Glu Leu Cys Ala Pro Gly Thr His Gly Lys Gly Cys Gln Leu 
            100                 105                 110         


Pro Cys Gln Cys Arg His Gly Ala Ser Cys Asp Pro Arg Ala Gly Glu 
        115                 120                 125             


Cys Leu Cys Ala Pro Gly Tyr Thr Gly Val Tyr Cys Glu Glu Leu Cys 
    130                 135                 140                 


Pro Pro Gly Ser His Gly Ala His Cys Glu Leu Arg Cys Pro Cys Gln 
145                 150                 155                 160 


Asn Gly Gly Thr Cys His His Ile Thr Gly Glu Cys Ala Cys Pro Pro 
                165                 170                 175     


Gly Trp Thr Gly Ala Val Cys Ala Gln Pro Cys Pro Pro Gly Thr Phe 
            180                 185                 190         


Gly Gln Asn Cys Ser Gln Asp Cys Pro Cys His His Gly Gly Gln Cys 
        195                 200                 205             


Asp His Val Thr Gly Gln Cys His Cys Thr Ala Gly Tyr Met Gly Asp 
    210                 215                 220                 


Arg Cys Gln Glu Glu Cys Pro Phe Gly Ser Phe Gly Phe Gln Cys Ser 
225                 230                 235                 240 


Gln Arg Cys Asp Cys His Asn Gly Gly Gln Cys Ser Pro Thr Thr Gly 
                245                 250                 255     


Ala Cys Glu Cys Glu Pro Gly Tyr Lys Gly Pro Arg Cys Gln Glu Arg 
            260                 265                 270         


Leu Cys Pro Glu Gly Leu His Gly Pro Gly Cys Thr Leu Pro Cys Pro 
        275                 280                 285             


Cys Asp Ala Asp Asn Thr Ile Ser Cys His Pro Val Thr Gly Ala Cys 
    290                 295                 300                 


Thr Cys Gln Pro Gly Trp Ser Gly His His Cys Asn Glu Ser Cys Pro 
305                 310                 315                 320 


Val Gly Tyr Tyr Gly Asp Gly Cys Gln Leu Pro Cys Thr Cys Gln Asn 
                325                 330                 335     


Gly Ala Asp Cys His Ser Ile Thr Gly Gly Cys Thr Cys Ala Pro Gly 
            340                 345                 350         


Phe Met Gly Glu Val Cys Ala Val Ser Cys Ala Ala Gly Thr Tyr Gly 
        355                 360                 365             


Pro Asn Cys Ser Ser Ile Cys Ser Cys Asn Asn Gly Gly Thr Cys Ser 
    370                 375                 380                 


Pro Val Asp Gly Ser Cys Thr Cys Lys Glu Gly Trp Gln Gly Leu Asp 
385                 390                 395                 400 


Cys Thr Leu Pro Cys Pro Ser Gly Thr Trp Gly Leu Asn Cys Asn Glu 
                405                 410                 415     


Ser Cys Thr Cys Ala Asn Gly Ala Ala Cys Ser Pro Ile Asp Gly Ser 
            420                 425                 430         


Cys Ser Cys Thr Pro Gly Trp Leu Gly Asp Thr Cys Glu Leu Pro Cys 
        435                 440                 445             


Pro Asp Gly Thr Phe Gly Leu Asn Cys Ser Glu His Cys Asp Cys Ser 
    450                 455                 460                 


His Ala Asp Gly Cys Asp Pro Val Thr Gly His Cys Cys Cys Leu Ala 
465                 470                 475                 480 


Gly Trp Thr Gly Ile Arg Cys Asp Ser Thr Cys Pro Pro Gly Arg Trp 
                485                 490                 495     


Gly Pro Asn Cys Ser Val Ser Cys Ser Cys Glu Asn Gly Gly Ser Cys 
            500                 505                 510         


Ser Pro Glu Asp Gly Ser Cys Glu Cys Ala Pro Gly Phe Arg Gly Pro 
        515                 520                 525             


Leu Cys Gln Arg Ile Cys Pro Pro Gly Phe Tyr Gly His Gly Cys Ala 
    530                 535                 540                 


Gln Pro Cys Pro Leu Cys Val His Ser Ser Arg Pro Cys His His Ile 
545                 550                 555                 560 


Ser Gly Ile Cys Glu Cys Leu Pro Gly Phe Ser Gly Ala Leu Cys Asn 
                565                 570                 575     


Gln Val Cys Ala Gly Gly Tyr Phe Gly Gln Asp Cys Ala Gln Leu Cys 
            580                 585                 590         


Ser Cys Ala Asn Asn Gly Thr Cys Ser Pro Ile Asp Gly Ser Cys Gln 
        595                 600                 605             


Cys Phe Pro Gly Trp Ile Gly Lys Asp Cys Ser Gln Ala Cys Pro Pro 
    610                 615                 620                 


Gly Phe Trp Gly Pro Ala Cys Phe His Ala Cys Ser Cys His Asn Gly 
625                 630                 635                 640 


Ala Ser Cys Ser Ala Glu Asp Gly Ala Cys His Cys Thr Pro Gly Trp 
                645                 650                 655     


Thr Gly Leu Phe Cys Thr Gln Arg Cys Pro Ala Ala Phe Phe Gly Lys 
            660                 665                 670         


Asp Cys Gly Arg Val Cys Gln Cys Gln Asn Gly Ala Ser Cys Asp His 
        675                 680                 685             


Ile Ser Gly Lys Cys Thr Cys Arg Thr Gly Phe Thr Gly Gln His Cys 
    690                 695                 700                 


Glu Gln Arg Cys Ala Pro Gly Thr Phe Gly Tyr Gly Cys Gln Gln Leu 
705                 710                 715                 720 


Cys Glu Cys Met Asn Asn Ser Thr Cys Asp His Val Thr Gly Thr Cys 
                725                 730                 735     


Tyr Cys Ser Pro Gly Phe Lys Gly Ile Arg Cys Asp Gln Ala Ala Leu 
            740                 745                 750         


Met Met Glu Glu Leu Asn Pro Tyr Thr Lys Ile Ser Pro Ala Leu Gly 
        755                 760                 765             


Ala Glu Arg His Ser Val Gly Ala Val Thr Gly Ile Met Leu Leu Leu 
    770                 775                 780                 


Phe Phe Ile Val Val Leu Leu Gly Leu Phe Ala Trp His Arg Arg Arg 
785                 790                 795                 800 


Gln Lys Glu Lys Gly Arg Asp Leu Ala Pro Arg Val Ser Tyr Thr Pro 
                805                 810                 815     


Ala Met Arg Met Thr Ser Thr Asp Tyr Ser Leu Ser Gly Ala Cys Gly 
            820                 825                 830         


Met Asp Arg Arg Gln Asn Thr Tyr Ile Met Asp Lys Gly Phe Lys Asp 
        835                 840                 845             


Tyr Met Lys Glu Ser Val Cys Ser Ser Ser Thr Cys Ser Leu Asn Ser 
    850                 855                 860                 


Ser Glu Asn Pro Tyr Ala Thr Ile Lys Asp Pro Pro Ile Leu Thr Cys 
865                 870                 875                 880 


Lys Leu Pro Glu Ser Ser Tyr Val Glu Met Lys Ser Pro Val His Met 
                885                 890                 895     


Gly Ser Pro Tyr Thr Asp Val Pro Ser Leu Ser Thr Ser Asn Lys Asn 
            900                 905                 910         


Ile Tyr Glu Val Glu Pro Thr Val Ser Val Val Gln Glu Gly Cys Gly 
        915                 920                 925             


His Asn Ser Ser Tyr Ile Gln Asn Ala Tyr Asp Leu Pro Arg Asn Ser 
    930                 935                 940                 


His Ile Pro Gly His Tyr Asp Leu Leu Pro Val Arg Gln Ser Pro Ala 
945                 950                 955                 960 


Asn Gly Pro Ser Gln Asp Lys Gln Ser 
                965                 


<210>  3316
<211>  3302
<212>  DNA
<213>  Homosapiens

<400>  3316
gcccccgctc cgccgcggag tttctgcatg actgtcacaa agatgtcctg gcgtccgcaa     60

taccgtagct ccaagttccg gaatgtctac gggaaggtgg ccaaccggga gcactgcttc    120

gatgggatcc ccatcaccaa gaatgtgcac gacaaccact tctgtgccgt caacacccgc    180

ttcctggcca tcgtcaccga gagcgcaggg ggcggctcct tcctcgtcat ccccctggag    240

cagacaggca ggattgaacc caactacccc aaggtctgcg gccaccaggg caatgtgctg    300

gatatcaaat ggaacccctt catcgacaac atcattgcct cgtgctcgga ggacacgtcg    360

gtgcggatct gggagatccc cgagggcggg ctgaagcgga acatgacgga ggcgctcctg    420

gagctgcacg ggcacagccg gcgtgtgggg ctggtcgagt ggcaccccac caccaacaac    480

atcctgttca gcgctggcta cgactacaag gtcctcatct ggaacctgga tgtgggtgag    540

ccggtgaaga tgattgactg ccacacggat gtgatcctct gcatgtcctt caacacggac    600

ggcagcctgc tcaccaccac gtgcaaggac aagaagctgc gtgtgattga gccccgctct    660

ggccgtgttc tgcaggaggc caactgcaaa aaccacagag tgaaccgggt ggtgttcctg    720

gggaacatga agcggctcct cacgacaggg gtctccaggt ggaacacaag acagattgcc    780

ctctgggacc aggaggacct ctccatgccc ctgatcgaag aggaaattga tgggctctct    840

ggcctcctgt tccccttcta tgatgctgac acccacatgc tctacctggc tggaaagggt    900

gatggaaaca tccggtacta cgagatcagc actgagaagc cctacctgag ttacctcatg    960

gagttccgct ccccagcccc gcagaaaggc ctaggggtca tgcccaagca cgggctggat   1020

gtgtcagcct gcgaggtgtt ccgcttctac aagctggtga ctctcaaggg cctgatcgag   1080

cccatctcca tgatcgtgcc ccggaggtca gattcctacc aggaagacat ttacccaatg   1140

acaccaggca cggagccagc actgaccccg gatgaatggc tgggaggcat caaccgagat   1200

cccgtgctga tgtctttgaa agaaggctat aagaagtcct caaaaatggt atttaaggct   1260

cccatcaaag aaaagaagag tgttgtggtc aacggaatag atttattaga aaatgtccca   1320

cccaggacag agaatgagct ccttcgaatg ttcttccggc agcaggatga gattcgacgg   1380

ttgaaagagg agctggccca gaaggacatc cgcattcggc agctccagct ggaactgaaa   1440

aacttgcgca acagccccaa gaactgttag ctccccagct gggctgtttt ctaagccgat   1500

ctctccgtcg tttctactca tcccttaact tctcccttac cagtgacccc agagacagag   1560

ccaggacagg agtgggggcc agcctgagga cccccgccta ccacctcgag aactggaagc   1620

caacctctaa cctcctgacc tcatgctaat aaaagtcccc agcttctgga gaccccctgc   1680

cggcagcccc tttccctgcc accccaggag ccaggcttcc cctcagctgg gtgaagacta   1740

cagactccct ggggttggca ggggctccat ctcagtggac caggaagcaa gaggggaagc   1800

gggatcccag ctagacttag aacttggact tttcccctgt gaagggggct gccaggacat   1860

ctcagcactc ccgcctggag ctctcagcat cactgaaggt accacagtgt aagtgctgga   1920

ctgcaggctg cagtgatccc tctttcgtcc caccccctct tccctcagca gccccggaag   1980

cctgcctcac ccgacgagga cagcgagcgg cccggctcct ttctgtctct tcccttccca   2040

ccctcttgtc ttcagggaat tcagaggatt gctctccaag gccataatga ccccttgcct   2100

tccccatgat tctctacaaa gctcttgcac acccttttcc cattcaattt gtgagccagg   2160

cagggtaggg attagtgtcc ccctttgaca aatgacagaa ctgagggttg caatggggaa   2220

atgacttata aagtcaccca gcaggtcaac aatgggccca cgaccaagac cctgggtgtt   2280

cagaccccaa ggccagggcc tttcccgctg catcaagatg ccaatccctt tgtgggcttc   2340

accagtgccc aagtctctat ggagaatgag aactggaagc cactgctacc gtctacccag   2400

caccagtagt gccgatgtgc cacactgccc agttgaggcc cctcacgctc tgtgccccta   2460

gatccttcag gtccccaccc tcagctgtca ccaccaccct ccccagggga ctccatctga   2520

gatgaggcct cgtcctcctg gaagctgagg ctgagaaggg tggagcttgg ccctggggaa   2580

ggcagaccag ggtctgatgg cttctaggga tgctctgcgt gtgtctcagc accgctatct   2640

cagccacttt cagccttatg cacgtagaat gaccacagcc actcgcatcc gtatagcact   2700

ttaaagtttc tgcagtcctt tgacacatag gatctcatgg agcctcacgt ctactccctt   2760

ctgcagatga ggaaaccgag agaagtggcc caaggtcacg caactctgag atgccacatt   2820

tcatttgatc ttgtacacat tttcttttat tccttctttt ttcctccttt catttcccac   2880

tacgcacaaa gagtttataa acactgttct cagaagagtc acagtttggg gtgagatctg   2940

gaaatcaaga aatgggtgtc cactcttttc tttcattagc taggatctac tagatgcatt   3000

atactccata cctgcttttc ccatggccgc cctacggaaa atcccatcca cagaggccag   3060

ggctacccaa gcccctccag gtgagctggg cctttccttt atgaacctcc atcctcccag   3120

ccagctacag tagggcctcc tcaccccgta ccccacagct agacagtgtc agcactcatc   3180

tcctcctccc acatttctgg agcttttttt tttccttccc cattgacctt tgtggtcttc   3240

tgtgattatt tatgctgcct cccaaggata gaattgaaat aaaatgtttt caacttatca   3300

aa                                                                  3302


<210>  3317
<211>  475
<212>  PRT
<213>  Homosapiens

<400>  3317

Met Ser Trp Arg Pro Gln Tyr Arg Ser Ser Lys Phe Arg Asn Val Tyr 
1               5                   10                  15      


Gly Lys Val Ala Asn Arg Glu His Cys Phe Asp Gly Ile Pro Ile Thr 
            20                  25                  30          


Lys Asn Val His Asp Asn His Phe Cys Ala Val Asn Thr Arg Phe Leu 
        35                  40                  45              


Ala Ile Val Thr Glu Ser Ala Gly Gly Gly Ser Phe Leu Val Ile Pro 
    50                  55                  60                  


Leu Glu Gln Thr Gly Arg Ile Glu Pro Asn Tyr Pro Lys Val Cys Gly 
65                  70                  75                  80  


His Gln Gly Asn Val Leu Asp Ile Lys Trp Asn Pro Phe Ile Asp Asn 
                85                  90                  95      


Ile Ile Ala Ser Cys Ser Glu Asp Thr Ser Val Arg Ile Trp Glu Ile 
            100                 105                 110         


Pro Glu Gly Gly Leu Lys Arg Asn Met Thr Glu Ala Leu Leu Glu Leu 
        115                 120                 125             


His Gly His Ser Arg Arg Val Gly Leu Val Glu Trp His Pro Thr Thr 
    130                 135                 140                 


Asn Asn Ile Leu Phe Ser Ala Gly Tyr Asp Tyr Lys Val Leu Ile Trp 
145                 150                 155                 160 


Asn Leu Asp Val Gly Glu Pro Val Lys Met Ile Asp Cys His Thr Asp 
                165                 170                 175     


Val Ile Leu Cys Met Ser Phe Asn Thr Asp Gly Ser Leu Leu Thr Thr 
            180                 185                 190         


Thr Cys Lys Asp Lys Lys Leu Arg Val Ile Glu Pro Arg Ser Gly Arg 
        195                 200                 205             


Val Leu Gln Glu Ala Asn Cys Lys Asn His Arg Val Asn Arg Val Val 
    210                 215                 220                 


Phe Leu Gly Asn Met Lys Arg Leu Leu Thr Thr Gly Val Ser Arg Trp 
225                 230                 235                 240 


Asn Thr Arg Gln Ile Ala Leu Trp Asp Gln Glu Asp Leu Ser Met Pro 
                245                 250                 255     


Leu Ile Glu Glu Glu Ile Asp Gly Leu Ser Gly Leu Leu Phe Pro Phe 
            260                 265                 270         


Tyr Asp Ala Asp Thr His Met Leu Tyr Leu Ala Gly Lys Gly Asp Gly 
        275                 280                 285             


Asn Ile Arg Tyr Tyr Glu Ile Ser Thr Glu Lys Pro Tyr Leu Ser Tyr 
    290                 295                 300                 


Leu Met Glu Phe Arg Ser Pro Ala Pro Gln Lys Gly Leu Gly Val Met 
305                 310                 315                 320 


Pro Lys His Gly Leu Asp Val Ser Ala Cys Glu Val Phe Arg Phe Tyr 
                325                 330                 335     


Lys Leu Val Thr Leu Lys Gly Leu Ile Glu Pro Ile Ser Met Ile Val 
            340                 345                 350         


Pro Arg Arg Ser Asp Ser Tyr Gln Glu Asp Ile Tyr Pro Met Thr Pro 
        355                 360                 365             


Gly Thr Glu Pro Ala Leu Thr Pro Asp Glu Trp Leu Gly Gly Ile Asn 
    370                 375                 380                 


Arg Asp Pro Val Leu Met Ser Leu Lys Glu Gly Tyr Lys Lys Ser Ser 
385                 390                 395                 400 


Lys Met Val Phe Lys Ala Pro Ile Lys Glu Lys Lys Ser Val Val Val 
                405                 410                 415     


Asn Gly Ile Asp Leu Leu Glu Asn Val Pro Pro Arg Thr Glu Asn Glu 
            420                 425                 430         


Leu Leu Arg Met Phe Phe Arg Gln Gln Asp Glu Ile Arg Arg Leu Lys 
        435                 440                 445             


Glu Glu Leu Ala Gln Lys Asp Ile Arg Ile Arg Gln Leu Gln Leu Glu 
    450                 455                 460                 


Leu Lys Asn Leu Arg Asn Ser Pro Lys Asn Cys 
465                 470                 475 


<210>  3318
<211>  1136
<212>  DNA
<213>  Homosapiens

<400>  3318
cgggtgctgg gggctcgaga accgagcgga gctggttgag ccttcaaagt cctaaaacgc     60

gcggccgtgg gttcggggtt tattgattga attccgccgg cgcgggagcc tctgcagaga    120

gagagcgcga gagatggaga tgggcagacg gattcattta gagctgcgga acaggacgcc    180

ctctgatgtg aaagaacttg tcctggacaa cagtcggtcg aatgaaggca aactcgaagg    240

cctcacagat gaatttgaag aactggaatt cttaagtaca atcaacgtag gcctcacctc    300

aatcgcaaac ttaccaaagt taaacaaact taagaagctt gaactaagcg ataacagagt    360

ctcagggggc ctggaagtat tggcagaaaa gtgtccgaac ctcacgcatc taaatttaag    420

tggcaacaaa attaaagacc tcagcacaat agagccactg aaaaagttag aaaacctcaa    480

gagcttagac cttttcaatt gcgaggtaac caacctgaac gactaccgag aaaatgtgtt    540

caagctcctc ccgcaactca catatctcga cggctatgac cgggacgaca aggaggcccc    600

tgactcggat gctgagggct acgtggaggg cctggatgat gaggaggagg atgaggatga    660

ggaggagtat gatgaagatg ctcaggtagt ggaagacgag gaggacgagg atgaggagga    720

ggaaggtgaa gaggaggacg tgagtggaga ggaggaggag gatgaagaag gttataacga    780

tggagaggta gatgacgagg aagatgaaga agagcttggt gaagaagaaa ggggtcagaa    840

gcgaaaacga gaacctgaag atgagggaga agatgatgac taagtggaat aacctatttt    900

gaaaaattcc tattgtgatt tgactgtttt tacccatatc ccctctcccc cccccctcca    960

atcctgcccc ctgaaactta tttttttctg attgtaacgt tgctgtggga acgagagggg   1020

aagagtgtac tgggggttgc ggggggaggg atggcgggtg ggggtggaat aaaatactat   1080

ttttactgcc actctttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa       1136


<210>  3319
<211>  249
<212>  PRT
<213>  Homosapiens

<400>  3319

Met Glu Met Gly Arg Arg Ile His Leu Glu Leu Arg Asn Arg Thr Pro 
1               5                   10                  15      


Ser Asp Val Lys Glu Leu Val Leu Asp Asn Ser Arg Ser Asn Glu Gly 
            20                  25                  30          


Lys Leu Glu Gly Leu Thr Asp Glu Phe Glu Glu Leu Glu Phe Leu Ser 
        35                  40                  45              


Thr Ile Asn Val Gly Leu Thr Ser Ile Ala Asn Leu Pro Lys Leu Asn 
    50                  55                  60                  


Lys Leu Lys Lys Leu Glu Leu Ser Asp Asn Arg Val Ser Gly Gly Leu 
65                  70                  75                  80  


Glu Val Leu Ala Glu Lys Cys Pro Asn Leu Thr His Leu Asn Leu Ser 
                85                  90                  95      


Gly Asn Lys Ile Lys Asp Leu Ser Thr Ile Glu Pro Leu Lys Lys Leu 
            100                 105                 110         


Glu Asn Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu 
        115                 120                 125             


Asn Asp Tyr Arg Glu Asn Val Phe Lys Leu Leu Pro Gln Leu Thr Tyr 
    130                 135                 140                 


Leu Asp Gly Tyr Asp Arg Asp Asp Lys Glu Ala Pro Asp Ser Asp Ala 
145                 150                 155                 160 


Glu Gly Tyr Val Glu Gly Leu Asp Asp Glu Glu Glu Asp Glu Asp Glu 
                165                 170                 175     


Glu Glu Tyr Asp Glu Asp Ala Gln Val Val Glu Asp Glu Glu Asp Glu 
            180                 185                 190         


Asp Glu Glu Glu Glu Gly Glu Glu Glu Asp Val Ser Gly Glu Glu Glu 
        195                 200                 205             


Glu Asp Glu Glu Gly Tyr Asn Asp Gly Glu Val Asp Asp Glu Glu Asp 
    210                 215                 220                 


Glu Glu Glu Leu Gly Glu Glu Glu Arg Gly Gln Lys Arg Lys Arg Glu 
225                 230                 235                 240 


Pro Glu Asp Glu Gly Glu Asp Asp Asp 
                245                 


<210>  3320
<211>  2357
<212>  DNA
<213>  Homosapiens

<400>  3320
gaatcacgac ccctccctgc catgtatccg cagggcagac atccggctcc ccatcaaccc     60

gggcagccgg gatttaaatt cacggtggct gagtcttgtg acaggatcaa agacgaattc    120

cagttcctgc aagctcagta tcacagcctc aaagtggagt acgacaagct ggcaaacgag    180

aagacggaga tgcagcgcca ttatgtgatg tactatgaga tgtcctatgg cttgaacatt    240

gaaatgcaca agcagacaga gattgcgaag agactgaaca caattttagc acagatcatg    300

cctttcctgt cacaagagca ccagcagcag gtggcgcagg cagtggagcg cgccaagcag    360

gtcaccatga cggagctgaa cgccatcatc gggcagcagc agctccaggc gcagcacctc    420

tcccatgcca cacacggccc cccggtccag ttgccacccc acccgtcagg tctccagcct    480

ccaggaatcc ccccagtgac agggagcagc tccgggctgc tggcactggg cgccctgggc    540

agccaggccc atctgacggt gaaggatgag aagaaccacc atgaactcga tcacagagag    600

agagaatcca gtgcgaataa ctctgtgtca ccctcggaaa gcctccgggc cagtgagaag    660

caccggggct ctgcggacta cagcatggaa gccaagaagc ggaaggtgga ggagaaggac    720

agcttgagcc gatacgacag tgatggagac aagagtgatg atctggtggt ggatgtttcc    780

aatgaggacc ccgcaacgcc ccgggtcagc ccggcacact cccctcctga aaatgggctg    840

gacaaggccc gtagcctgaa aaaagatgcc cccaccagcc ctgcctcggt ggcctcttcc    900

agtagcacac cttcctccaa gaccaaagac cttggtcata acgacaaatc ctccacccct    960

gggctcaagt ccaacacacc aaccccaagg aacgacgccc caactccagg caccagcacg   1020

accccagggc tcaggtcgat gccgggtaaa cctccgggca tggacccgat aggtataatg   1080

gcctcggctc tgcgcacgcc catctccatc accagctcct atgcggcgcc cttcgccatg   1140

atgagccacc atgagatgaa cggctccctc accagtcctg gcgcctacgc cggcctccac   1200

aacatcccac cccagatgag cgccgccgcc gctgctgcag ccgctgccta tggccgatcg   1260

ccaatggtga gctttggagc tgttggtttt gaccctcacc ccccgatgcg ggccacaggc   1320

ctcccctcaa gcctggcctc cattcctgga ggaaaaccag cgtactcatt ccatgtgagt   1380

gctgatgggc agatgcagcc cgtgcccttc ccccacgacg ccctggcagg ccccggcatc   1440

ccgaggcacg cccggcagat caacacactc agccacgggg gggtggtgtg tgccgtgacc   1500

atcagcaacc ccagcaggca cgtctacaca ggtggcaagg gctgcgtgaa gatctgggac   1560

atcagccagc caggcagcaa gagccccatc tcccagctgg actgcctgaa cagggacaat   1620

tacatgcgct cctgcaagct gcaccctgat gggcgcacgc tcatcgtggg cggcgagggc   1680

agcacgctca ccatctggga cctggcctcg cccacgcccc gcatcaaggc cgagctgacg   1740

tcctcggctc ccgcctgtta tgccctggcc attagccctg acgccaaagt ctgcttctcc   1800

tgctgcagcg atgggaacat tgctgtctgg gacctgcaca accagaccct ggtcaggcag   1860

ttccagggcc acacagatgg ggccagctgc atagacatct cccatgatgg caccaaactg   1920

tggacagggg gcctggacaa cacggtgcgc tcctgggacc tgcgggaggg ccgacagcta   1980

cagcagcatg acttcacttc ccagatcttc tcgctgggct actgccccac tggggagtgg   2040

ctggctgtgg gcatggagag cagcaacgtg gaggtgctgc accacaccaa gcctcacaag   2100

taccagctgc acctgcacga gagctgcgtg ctctccctca agttcgccta ctgcggcaag   2160

tggttcgtga gcactgggaa agataacctt ctcaacgcct ggaggacgcc ttatggagcc   2220

agcatatccc agtctaaaga atcctcgtct gtcttgagtt gtgacatttc agcggatgac   2280

aaatacattg taacaggctc tggtgacaag aaggccacag tttatgaggt catctactaa   2340

acaagaactc cagcagg                                                  2357


<210>  3321
<211>  772
<212>  PRT
<213>  Homosapiens

<400>  3321

Met Tyr Pro Gln Gly Arg His Pro Ala Pro His Gln Pro Gly Gln Pro 
1               5                   10                  15      


Gly Phe Lys Phe Thr Val Ala Glu Ser Cys Asp Arg Ile Lys Asp Glu 
            20                  25                  30          


Phe Gln Phe Leu Gln Ala Gln Tyr His Ser Leu Lys Val Glu Tyr Asp 
        35                  40                  45              


Lys Leu Ala Asn Glu Lys Thr Glu Met Gln Arg His Tyr Val Met Tyr 
    50                  55                  60                  


Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys Gln Thr Glu 
65                  70                  75                  80  


Ile Ala Lys Arg Leu Asn Thr Ile Leu Ala Gln Ile Met Pro Phe Leu 
                85                  90                  95      


Ser Gln Glu His Gln Gln Gln Val Ala Gln Ala Val Glu Arg Ala Lys 
            100                 105                 110         


Gln Val Thr Met Thr Glu Leu Asn Ala Ile Ile Gly Gln Gln Gln Leu 
        115                 120                 125             


Gln Ala Gln His Leu Ser His Ala Thr His Gly Pro Pro Val Gln Leu 
    130                 135                 140                 


Pro Pro His Pro Ser Gly Leu Gln Pro Pro Gly Ile Pro Pro Val Thr 
145                 150                 155                 160 


Gly Ser Ser Ser Gly Leu Leu Ala Leu Gly Ala Leu Gly Ser Gln Ala 
                165                 170                 175     


His Leu Thr Val Lys Asp Glu Lys Asn His His Glu Leu Asp His Arg 
            180                 185                 190         


Glu Arg Glu Ser Ser Ala Asn Asn Ser Val Ser Pro Ser Glu Ser Leu 
        195                 200                 205             


Arg Ala Ser Glu Lys His Arg Gly Ser Ala Asp Tyr Ser Met Glu Ala 
    210                 215                 220                 


Lys Lys Arg Lys Val Glu Glu Lys Asp Ser Leu Ser Arg Tyr Asp Ser 
225                 230                 235                 240 


Asp Gly Asp Lys Ser Asp Asp Leu Val Val Asp Val Ser Asn Glu Asp 
                245                 250                 255     


Pro Ala Thr Pro Arg Val Ser Pro Ala His Ser Pro Pro Glu Asn Gly 
            260                 265                 270         


Leu Asp Lys Ala Arg Ser Leu Lys Lys Asp Ala Pro Thr Ser Pro Ala 
        275                 280                 285             


Ser Val Ala Ser Ser Ser Ser Thr Pro Ser Ser Lys Thr Lys Asp Leu 
    290                 295                 300                 


Gly His Asn Asp Lys Ser Ser Thr Pro Gly Leu Lys Ser Asn Thr Pro 
305                 310                 315                 320 


Thr Pro Arg Asn Asp Ala Pro Thr Pro Gly Thr Ser Thr Thr Pro Gly 
                325                 330                 335     


Leu Arg Ser Met Pro Gly Lys Pro Pro Gly Met Asp Pro Ile Gly Ile 
            340                 345                 350         


Met Ala Ser Ala Leu Arg Thr Pro Ile Ser Ile Thr Ser Ser Tyr Ala 
        355                 360                 365             


Ala Pro Phe Ala Met Met Ser His His Glu Met Asn Gly Ser Leu Thr 
    370                 375                 380                 


Ser Pro Gly Ala Tyr Ala Gly Leu His Asn Ile Pro Pro Gln Met Ser 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr Gly Arg Ser Pro Met Val 
                405                 410                 415     


Ser Phe Gly Ala Val Gly Phe Asp Pro His Pro Pro Met Arg Ala Thr 
            420                 425                 430         


Gly Leu Pro Ser Ser Leu Ala Ser Ile Pro Gly Gly Lys Pro Ala Tyr 
        435                 440                 445             


Ser Phe His Val Ser Ala Asp Gly Gln Met Gln Pro Val Pro Phe Pro 
    450                 455                 460                 


His Asp Ala Leu Ala Gly Pro Gly Ile Pro Arg His Ala Arg Gln Ile 
465                 470                 475                 480 


Asn Thr Leu Ser His Gly Gly Val Val Cys Ala Val Thr Ile Ser Asn 
                485                 490                 495     


Pro Ser Arg His Val Tyr Thr Gly Gly Lys Gly Cys Val Lys Ile Trp 
            500                 505                 510         


Asp Ile Ser Gln Pro Gly Ser Lys Ser Pro Ile Ser Gln Leu Asp Cys 
        515                 520                 525             


Leu Asn Arg Asp Asn Tyr Met Arg Ser Cys Lys Leu His Pro Asp Gly 
    530                 535                 540                 


Arg Thr Leu Ile Val Gly Gly Glu Gly Ser Thr Leu Thr Ile Trp Asp 
545                 550                 555                 560 


Leu Ala Ser Pro Thr Pro Arg Ile Lys Ala Glu Leu Thr Ser Ser Ala 
                565                 570                 575     


Pro Ala Cys Tyr Ala Leu Ala Ile Ser Pro Asp Ala Lys Val Cys Phe 
            580                 585                 590         


Ser Cys Cys Ser Asp Gly Asn Ile Ala Val Trp Asp Leu His Asn Gln 
        595                 600                 605             


Thr Leu Val Arg Gln Phe Gln Gly His Thr Asp Gly Ala Ser Cys Ile 
    610                 615                 620                 


Asp Ile Ser His Asp Gly Thr Lys Leu Trp Thr Gly Gly Leu Asp Asn 
625                 630                 635                 640 


Thr Val Arg Ser Trp Asp Leu Arg Glu Gly Arg Gln Leu Gln Gln His 
                645                 650                 655     


Asp Phe Thr Ser Gln Ile Phe Ser Leu Gly Tyr Cys Pro Thr Gly Glu 
            660                 665                 670         


Trp Leu Ala Val Gly Met Glu Ser Ser Asn Val Glu Val Leu His His 
        675                 680                 685             


Thr Lys Pro His Lys Tyr Gln Leu His Leu His Glu Ser Cys Val Leu 
    690                 695                 700                 


Ser Leu Lys Phe Ala Tyr Cys Gly Lys Trp Phe Val Ser Thr Gly Lys 
705                 710                 715                 720 


Asp Asn Leu Leu Asn Ala Trp Arg Thr Pro Tyr Gly Ala Ser Ile Ser 
                725                 730                 735     


Gln Ser Lys Glu Ser Ser Ser Val Leu Ser Cys Asp Ile Ser Ala Asp 
            740                 745                 750         


Asp Lys Tyr Ile Val Thr Gly Ser Gly Asp Lys Lys Ala Thr Val Tyr 
        755                 760                 765             


Glu Val Ile Tyr 
    770         


<210>  3322
<211>  1614
<212>  DNA
<213>  Homosapiens

<400>  3322
atggcccagt cgcctcctcc gcagagcctc ctcggccacg accactggat cttcgcccag     60

ggctggggct gggccggcca ctgggactcc acgtccccgg cctcctcctc cgattcgtcg    120

ggttcgtgcc cctgcgacgg cgcccgcgga ctcccgcagc cacagcctcc gagctgcagc    180

tcccgagccg cagaggcagc cgcgacgacg cccagacgag cgcgcaccgg accagcgggc    240

ggacagcggc agagcgccag cgagcgggag aaactgcgca tgcgcacgct ggcccgcgcc    300

ctgcacgagt tgcgccgctt tctgcctccc tccttggcgc cggccggcca gagcctgacc    360

aagatcgaga cgctgcgcct ggccatccgc tacatcggcc acctatcggc cgtgctgggt    420

ctcagcgagg agagtctgca gtgccggcgc aggcagcgcg gggacgcggg gtccccttgg    480

ggctgcccgc tgtgccccga ccgtggcccc gcagaggcgc agacgcaggc ggaggggcag    540

gggcaagggc aggggcaggg gcaggggcaa gggcaggggc aaggacaggg gcaaggacag    600

gggcaagggc aggggcgcag gccgggcctg gtctccgccg tcctcgccga ggcgtcctgg    660

ggatccccgt ccgcctgccc cggagcccaa gccgcacccg agcgcctggg gaggggggtc    720

cacgacacgg atccctgggc aacaccccct tactgcccca agatacagtc gcccccgtat    780

tcgtcccaag ggacaacctc cgacgcgtct ctttggacgc caccccaagg ctgtccctgg    840

acgcagtcgt ccccagagcc ccggaaccca ccagtgccct ggacggcggc cccagcaact    900

ttggagctgg ccgcagtgta ccagggtctc tctgtgtctc cagagccctg tctgtcgctg    960

ggagctccat ctctcctgcc ccacccatca tgccagagac tgcagcctca gacccccggg   1020

aggtgctgga gccacagtgc agaggtggtg cccaactcag aggaccaggg accgggcgcc   1080

gccttccagc tcagtgaagc aagccctccc cagagctcag gcctgcggtt cagtggctgc   1140

cctgaacttt ggcaagaaga tctggagggg gcccgcctgg gcatcttcta ctaaatggcc   1200

tcggcttccc tctttccatc caggaatcag tcctgtagct tgggtgcctc cttatttgtt   1260

aattagtggc ttttcatgtt ctcctttagc caaggctccc tttttccaag tgatgtcttt   1320

cagggaagca gtgtttgaaa tagatagcgg gtaccttccc tggatggagt cagggcgggg   1380

gcactgtcct ccactgctag acacccccag aatgcctggc gctctgcaga gcacagtctg   1440

agctgctcta agaaggggtc tcctttaccc taaaggcagc tgggcaggga caggtgggag   1500

aatgggtgta ggaggcaggc cccaggctct gcttcttggt gacagttggc cagagccctg   1560

tatgctttga tttttttgta cttaaaaaga aaaaacacac acacacaaca aaaa         1614


<210>  3323
<211>  397
<212>  PRT
<213>  Homosapiens

<400>  3323

Met Ala Gln Ser Pro Pro Pro Gln Ser Leu Leu Gly His Asp His Trp 
1               5                   10                  15      


Ile Phe Ala Gln Gly Trp Gly Trp Ala Gly His Trp Asp Ser Thr Ser 
            20                  25                  30          


Pro Ala Ser Ser Ser Asp Ser Ser Gly Ser Cys Pro Cys Asp Gly Ala 
        35                  40                  45              


Arg Gly Leu Pro Gln Pro Gln Pro Pro Ser Cys Ser Ser Arg Ala Ala 
    50                  55                  60                  


Glu Ala Ala Ala Thr Thr Pro Arg Arg Ala Arg Thr Gly Pro Ala Gly 
65                  70                  75                  80  


Gly Gln Arg Gln Ser Ala Ser Glu Arg Glu Lys Leu Arg Met Arg Thr 
                85                  90                  95      


Leu Ala Arg Ala Leu His Glu Leu Arg Arg Phe Leu Pro Pro Ser Leu 
            100                 105                 110         


Ala Pro Ala Gly Gln Ser Leu Thr Lys Ile Glu Thr Leu Arg Leu Ala 
        115                 120                 125             


Ile Arg Tyr Ile Gly His Leu Ser Ala Val Leu Gly Leu Ser Glu Glu 
    130                 135                 140                 


Ser Leu Gln Cys Arg Arg Arg Gln Arg Gly Asp Ala Gly Ser Pro Trp 
145                 150                 155                 160 


Gly Cys Pro Leu Cys Pro Asp Arg Gly Pro Ala Glu Ala Gln Thr Gln 
                165                 170                 175     


Ala Glu Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln 
            180                 185                 190         


Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Arg Arg Pro 
        195                 200                 205             


Gly Leu Val Ser Ala Val Leu Ala Glu Ala Ser Trp Gly Ser Pro Ser 
    210                 215                 220                 


Ala Cys Pro Gly Ala Gln Ala Ala Pro Glu Arg Leu Gly Arg Gly Val 
225                 230                 235                 240 


His Asp Thr Asp Pro Trp Ala Thr Pro Pro Tyr Cys Pro Lys Ile Gln 
                245                 250                 255     


Ser Pro Pro Tyr Ser Ser Gln Gly Thr Thr Ser Asp Ala Ser Leu Trp 
            260                 265                 270         


Thr Pro Pro Gln Gly Cys Pro Trp Thr Gln Ser Ser Pro Glu Pro Arg 
        275                 280                 285             


Asn Pro Pro Val Pro Trp Thr Ala Ala Pro Ala Thr Leu Glu Leu Ala 
    290                 295                 300                 


Ala Val Tyr Gln Gly Leu Ser Val Ser Pro Glu Pro Cys Leu Ser Leu 
305                 310                 315                 320 


Gly Ala Pro Ser Leu Leu Pro His Pro Ser Cys Gln Arg Leu Gln Pro 
                325                 330                 335     


Gln Thr Pro Gly Arg Cys Trp Ser His Ser Ala Glu Val Val Pro Asn 
            340                 345                 350         


Ser Glu Asp Gln Gly Pro Gly Ala Ala Phe Gln Leu Ser Glu Ala Ser 
        355                 360                 365             


Pro Pro Gln Ser Ser Gly Leu Arg Phe Ser Gly Cys Pro Glu Leu Trp 
    370                 375                 380                 


Gln Glu Asp Leu Glu Gly Ala Arg Leu Gly Ile Phe Tyr 
385                 390                 395         


<210>  3324
<211>  3494
<212>  DNA
<213>  Homosapiens

<400>  3324
taatttttgc ccagtctgcc tgttgtgggg ctcctcccct ttggggatat aagcccggcc     60

tggggctgct ccgttctctg cctggcctga ggctccctga gccgcctccc caccatcacc    120

atggccaagg gcttctatat ttccaagtcc ctgggcatcc tggggatcct cctgggcgtg    180

gcagccgtgt gcacaatcat cgcactgtca gtggtgtact cccaggagaa gaacaagaac    240

gccaacagct cccccgtggc ctccaccacc ccgtccgcct cagccaccac caaccccgcc    300

tcggccacca ccttggacca aagtaaagcg tggaatcgtt accgcctccc caacacgctg    360

aaacccgatt cctaccaggt gacgctgaga ccgtacctca cccccaatga caggggcctg    420

tacgttttta agggctccag caccgtccgt ttcacctgca aggaggccac tgacgtcatc    480

atcatccaca gcaagaagct caactacacc ctcagccagg ggcacagggt ggtcctgcgt    540

ggtgtgggag gctcccagcc ccccgacatt gacaagactg agctggtgga gcccaccgag    600

tacctggtgg tgcacctcaa gggctccctg gtgaaggaca gccagtatga gatggacagc    660

gagttcgagg gggagttggc agatgacctg gcgggcttct accgcagcga gtacatggag    720

ggcaatgtca gaaaggtggt ggccactaca cagatgcagg ctgcagatgc ccggaagtcc    780

ttcccatgct tcgatgagcc ggccatgaag gccgagttca acatcacgct tatccacccc    840

aaggacctga cagccctgtc caacatgctt cccaaaggtc ccagcacccc acttccagaa    900

gaccccaact ggaatgtcac tgagttccac accacgccca agatgtccac gtacttgctg    960

gccttcattg tcagtgagtt cgactacgtg gagaagcagg catccaatgg tgtcttgatc   1020

cggatctggg cccggcccag tgccattgcg gcgggccacg gcgattatgc cctgaacgtg   1080

acgggcccca tccttaactt ctttgctggt cattatgaca caccctaccc actcccaaaa   1140

tcagaccaga ttggcctgcc agacttcaac gccggcgcca tggagaactg gggactggtg   1200

acctaccggg agaactccct gctgttcgac cccctgtcct cctccagcag caacaaggag   1260

cgggtggtca ctgtgattgc tcatgagctg gcccaccagt ggttcgggaa cctggtgacc   1320

atagagtggt ggaatgacct gtggctgaac gagggcttcg cctcctacgt ggagtacctg   1380

ggtgctgact atgcggagcc cacctggaac ttgaaagacc tcatggtgct gaatgatgtg   1440

taccgcgtga tggcagtgga tgcactggcc tcctcccacc cgctgtccac acccgcctcg   1500

gagatcaaca cgccggccca gatcagtgag ctgtttgacg ccatctccta cagcaagggc   1560

gcctcagtcc tcaggatgct ctccagcttc ctgtccgagg acgtattcaa gcagggcctg   1620

gcgtcctacc tccacacctt tgcctaccag aacaccatct acctgaacct gtgggaccac   1680

ctgcaggagg ctgtgaacaa ccggtccatc caactcccca ccaccgtgcg ggacatcatg   1740

aaccgctgga ccctgcagat gggcttcccg gtcatcacgg tggataccag cacggggacc   1800

ctttcccagg agcacttcct ccttgacccc gattccaatg ttacccgccc ctcagaattc   1860

aactacgtgt ggattgtgcc catcacatcc atcagagatg gcagacagca gcaggactac   1920

tggctgatag atgtaagagc ccagaacgat ctcttcagca catcaggcaa tgagtgggtc   1980

ctgctgaacc tcaatgtgac gggctattac cgggtgaact acgacgaaga gaactggagg   2040

aagattcaga ctcagctgca gagagaccac tcggccatcc ctgtcatcaa tcgggcacag   2100

atcattaatg acgccttcaa cctggccagt gcccataagg tccctgtcac tctggcgctg   2160

aacaacaccc tcttcctgat tgaagagaga cagtacatgc cctgggaggc cgccctgagc   2220

agcctgagct acttcaagct catgtttgac cgctccgagg tctatggccc catgaagaac   2280

tacctgaaga agcaggtcac acccctcttc attcacttca gaaataatac caacaactgg   2340

agggagatcc cagaaaacct gatggaccag tacagcgagg ttaatgccat cagcaccgcc   2400

tgctccaacg gagttccaga gtgtgaggag atggtctctg gccttttcaa gcagtggatg   2460

gagaacccca ataataaccc gatccacccc aacctgcggt ccaccgtcta ctgcaacgct   2520

atcgcccagg gcggggagga ggagtgggac ttcgcctggg agcagttccg aaatgccaca   2580

ctggtcaatg aggctgacaa gctccgggca gccctggcct gcagcaaaga gttgtggatc   2640

ctgaacaggt acctgagcta caccctgaac ccggacttaa tccggaagca ggacgccacc   2700

tctaccatca tcagcattac caacaacgtc attgggcaag gtctggtctg ggactttgtc   2760

cagagcaact ggaagaagct ttttaacgat tatggtggtg gctcgttctc cttctccaac   2820

ctcatccagg cagtgacacg acgattctcc accgagtatg agctgcagca gctggagcag   2880

ttcaagaagg acaacgagga aacaggcttc ggctcaggca cccgggccct ggagcaagcc   2940

ctggagaaga cgaaagccaa catcaagtgg gtgaaggaga acaaggaggt ggtgctccag   3000

tggttcacag aaaacagcaa atagtcccca gcccttgaag tcacccggcc ccgatgcaag   3060

gtgcccacat gtgtccatcc cagcggctgg tgcagggcct ccattcctgg agcccgaggc   3120

accagtgtcc tcccctcaag gacaaagtct ccagcccacg ttctctctgc ctgtgagcca   3180

gtctagttcc tgatgaccca ggctgcctga gcacctccca gcccctgccc ctcatgccaa   3240

ccccgcccta ggcctggcat ggcacctgtc gcccagtgcc ctggggctga tctcagggaa   3300

gcccagctcc agggccagat gagcagaagc tctcgatgga caatgaacgg ccttgctggg   3360

ggccgccctg taccctcttt cacctttccc taaagaccct aaatctgagg aatcaacagg   3420

gcagcagatc tgtatatttt tttctaagag aaaatgtaaa taaaggattt ctagatgaaa   3480

aaaaaaaaaa aaaa                                                     3494


<210>  3325
<211>  967
<212>  PRT
<213>  Homosapiens

<400>  3325

Met Ala Lys Gly Phe Tyr Ile Ser Lys Ser Leu Gly Ile Leu Gly Ile 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Val Cys Thr Ile Ile Ala Leu Ser Val Val 
            20                  25                  30          


Tyr Ser Gln Glu Lys Asn Lys Asn Ala Asn Ser Ser Pro Val Ala Ser 
        35                  40                  45              


Thr Thr Pro Ser Ala Ser Ala Thr Thr Asn Pro Ala Ser Ala Thr Thr 
    50                  55                  60                  


Leu Asp Gln Ser Lys Ala Trp Asn Arg Tyr Arg Leu Pro Asn Thr Leu 
65                  70                  75                  80  


Lys Pro Asp Ser Tyr Gln Val Thr Leu Arg Pro Tyr Leu Thr Pro Asn 
                85                  90                  95      


Asp Arg Gly Leu Tyr Val Phe Lys Gly Ser Ser Thr Val Arg Phe Thr 
            100                 105                 110         


Cys Lys Glu Ala Thr Asp Val Ile Ile Ile His Ser Lys Lys Leu Asn 
        115                 120                 125             


Tyr Thr Leu Ser Gln Gly His Arg Val Val Leu Arg Gly Val Gly Gly 
    130                 135                 140                 


Ser Gln Pro Pro Asp Ile Asp Lys Thr Glu Leu Val Glu Pro Thr Glu 
145                 150                 155                 160 


Tyr Leu Val Val His Leu Lys Gly Ser Leu Val Lys Asp Ser Gln Tyr 
                165                 170                 175     


Glu Met Asp Ser Glu Phe Glu Gly Glu Leu Ala Asp Asp Leu Ala Gly 
            180                 185                 190         


Phe Tyr Arg Ser Glu Tyr Met Glu Gly Asn Val Arg Lys Val Val Ala 
        195                 200                 205             


Thr Thr Gln Met Gln Ala Ala Asp Ala Arg Lys Ser Phe Pro Cys Phe 
    210                 215                 220                 


Asp Glu Pro Ala Met Lys Ala Glu Phe Asn Ile Thr Leu Ile His Pro 
225                 230                 235                 240 


Lys Asp Leu Thr Ala Leu Ser Asn Met Leu Pro Lys Gly Pro Ser Thr 
                245                 250                 255     


Pro Leu Pro Glu Asp Pro Asn Trp Asn Val Thr Glu Phe His Thr Thr 
            260                 265                 270         


Pro Lys Met Ser Thr Tyr Leu Leu Ala Phe Ile Val Ser Glu Phe Asp 
        275                 280                 285             


Tyr Val Glu Lys Gln Ala Ser Asn Gly Val Leu Ile Arg Ile Trp Ala 
    290                 295                 300                 


Arg Pro Ser Ala Ile Ala Ala Gly His Gly Asp Tyr Ala Leu Asn Val 
305                 310                 315                 320 


Thr Gly Pro Ile Leu Asn Phe Phe Ala Gly His Tyr Asp Thr Pro Tyr 
                325                 330                 335     


Pro Leu Pro Lys Ser Asp Gln Ile Gly Leu Pro Asp Phe Asn Ala Gly 
            340                 345                 350         


Ala Met Glu Asn Trp Gly Leu Val Thr Tyr Arg Glu Asn Ser Leu Leu 
        355                 360                 365             


Phe Asp Pro Leu Ser Ser Ser Ser Ser Asn Lys Glu Arg Val Val Thr 
    370                 375                 380                 


Val Ile Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr 
385                 390                 395                 400 


Ile Glu Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Ser Tyr 
                405                 410                 415     


Val Glu Tyr Leu Gly Ala Asp Tyr Ala Glu Pro Thr Trp Asn Leu Lys 
            420                 425                 430         


Asp Leu Met Val Leu Asn Asp Val Tyr Arg Val Met Ala Val Asp Ala 
        435                 440                 445             


Leu Ala Ser Ser His Pro Leu Ser Thr Pro Ala Ser Glu Ile Asn Thr 
    450                 455                 460                 


Pro Ala Gln Ile Ser Glu Leu Phe Asp Ala Ile Ser Tyr Ser Lys Gly 
465                 470                 475                 480 


Ala Ser Val Leu Arg Met Leu Ser Ser Phe Leu Ser Glu Asp Val Phe 
                485                 490                 495     


Lys Gln Gly Leu Ala Ser Tyr Leu His Thr Phe Ala Tyr Gln Asn Thr 
            500                 505                 510         


Ile Tyr Leu Asn Leu Trp Asp His Leu Gln Glu Ala Val Asn Asn Arg 
        515                 520                 525             


Ser Ile Gln Leu Pro Thr Thr Val Arg Asp Ile Met Asn Arg Trp Thr 
    530                 535                 540                 


Leu Gln Met Gly Phe Pro Val Ile Thr Val Asp Thr Ser Thr Gly Thr 
545                 550                 555                 560 


Leu Ser Gln Glu His Phe Leu Leu Asp Pro Asp Ser Asn Val Thr Arg 
                565                 570                 575     


Pro Ser Glu Phe Asn Tyr Val Trp Ile Val Pro Ile Thr Ser Ile Arg 
            580                 585                 590         


Asp Gly Arg Gln Gln Gln Asp Tyr Trp Leu Ile Asp Val Arg Ala Gln 
        595                 600                 605             


Asn Asp Leu Phe Ser Thr Ser Gly Asn Glu Trp Val Leu Leu Asn Leu 
    610                 615                 620                 


Asn Val Thr Gly Tyr Tyr Arg Val Asn Tyr Asp Glu Glu Asn Trp Arg 
625                 630                 635                 640 


Lys Ile Gln Thr Gln Leu Gln Arg Asp His Ser Ala Ile Pro Val Ile 
                645                 650                 655     


Asn Arg Ala Gln Ile Ile Asn Asp Ala Phe Asn Leu Ala Ser Ala His 
            660                 665                 670         


Lys Val Pro Val Thr Leu Ala Leu Asn Asn Thr Leu Phe Leu Ile Glu 
        675                 680                 685             


Glu Arg Gln Tyr Met Pro Trp Glu Ala Ala Leu Ser Ser Leu Ser Tyr 
    690                 695                 700                 


Phe Lys Leu Met Phe Asp Arg Ser Glu Val Tyr Gly Pro Met Lys Asn 
705                 710                 715                 720 


Tyr Leu Lys Lys Gln Val Thr Pro Leu Phe Ile His Phe Arg Asn Asn 
                725                 730                 735     


Thr Asn Asn Trp Arg Glu Ile Pro Glu Asn Leu Met Asp Gln Tyr Ser 
            740                 745                 750         


Glu Val Asn Ala Ile Ser Thr Ala Cys Ser Asn Gly Val Pro Glu Cys 
        755                 760                 765             


Glu Glu Met Val Ser Gly Leu Phe Lys Gln Trp Met Glu Asn Pro Asn 
    770                 775                 780                 


Asn Asn Pro Ile His Pro Asn Leu Arg Ser Thr Val Tyr Cys Asn Ala 
785                 790                 795                 800 


Ile Ala Gln Gly Gly Glu Glu Glu Trp Asp Phe Ala Trp Glu Gln Phe 
                805                 810                 815     


Arg Asn Ala Thr Leu Val Asn Glu Ala Asp Lys Leu Arg Ala Ala Leu 
            820                 825                 830         


Ala Cys Ser Lys Glu Leu Trp Ile Leu Asn Arg Tyr Leu Ser Tyr Thr 
        835                 840                 845             


Leu Asn Pro Asp Leu Ile Arg Lys Gln Asp Ala Thr Ser Thr Ile Ile 
    850                 855                 860                 


Ser Ile Thr Asn Asn Val Ile Gly Gln Gly Leu Val Trp Asp Phe Val 
865                 870                 875                 880 


Gln Ser Asn Trp Lys Lys Leu Phe Asn Asp Tyr Gly Gly Gly Ser Phe 
                885                 890                 895     


Ser Phe Ser Asn Leu Ile Gln Ala Val Thr Arg Arg Phe Ser Thr Glu 
            900                 905                 910         


Tyr Glu Leu Gln Gln Leu Glu Gln Phe Lys Lys Asp Asn Glu Glu Thr 
        915                 920                 925             


Gly Phe Gly Ser Gly Thr Arg Ala Leu Glu Gln Ala Leu Glu Lys Thr 
    930                 935                 940                 


Lys Ala Asn Ile Lys Trp Val Lys Glu Asn Lys Glu Val Val Leu Gln 
945                 950                 955                 960 


Trp Phe Thr Glu Asn Ser Lys 
                965         


<210>  3326
<211>  2578
<212>  DNA
<213>  Homosapiens

<400>  3326
agagaaccgt ggctggcaaa gatgattcag gcgattctgg ttttcaacaa ccatgggaag     60

ccacggctag tccgcttcta ccagcgtttc ccagaagaaa ttcaacagca gattgttcga    120

gagactttcc atctagtcct caagcgggat gacaacatct gtaacttctt ggagggtgga    180

agtttgattg gtggctctga ctacaaactg atctaccggc actatgctac cctctacttt    240

gtattttgtg tggattcctc agagagtgaa cttggaatct tggacctcat ccaggttttt    300

gtggaaactc tggataagtg tttcgaaaat gtgtgtgaat tggatttgat cttccatatg    360

gataaggtgc actacatcct ccaggaggtg gtgatgggtg ggatggtgtt ggaaacaaac    420

atgaatgaaa tcgtggctca gattgaggct caaaacaggc tggagaaatc cgagggtggc    480

ctttcagcag cccctgcgcg ggctgtgtct gctgtgaaaa acatcaacct gccagagatt    540

cctcggaaca tcaacattgg cgatctcaac atcaaagttc ccaacctgtc ccagtttgtc    600

tgaggatcaa gtattggcct gaaatagagt ccttaagaca agcaaagaca agcaaggcaa    660

gcacgtctgg aaacagaacc cattttgagc cttagaagag tcaagcctca ggacctggaa    720

actttgtgtc tggggaagac tgtttggcat ggaataggga agggattcct attgacactg    780

ctcgggtgca cccagttctc acatgtgcag tcatgccgtt ctctgatgca tacggccact    840

gcagatgtga ggggccctgc cttcctcagt agggagtcaa catgcccaag tcatttgcac    900

ctttacctct cacatggatg ctcccaaggg ttagggactg cattgagcag gcccacctgc    960

ttcccagaac ctcctcacta gggctgagca ccttctctga gtagagtctt catccttagc   1020

accacagact tctgaggtcc tgtgcccttt acttgctggt gaggtgtcat aggtagaaaa   1080

gggctggccc ttcagatctg ggggtgtggt gagtggcaag taagggcaga attttaggag   1140

aaccagagtc acccgctggc tctactgaga ttgttacacc cagaatcctt ttgtgttttt   1200

ttgtggtttt tttttttgag gtggagtctt gctctgtcac ccaggctgga gtgctgtggt   1260

gcaatctcgg ctcactgcaa cctctgcttc ccgggttcaa gcatttctcc tgtctcagcc   1320

tccccagtag ctgggattac aggcacccac caccatgccc agctaattgt tgtatgttta   1380

gtagagacag ggtttcacca tgttggccag gctgggcccg aactcctgga cctcaagtga   1440

tctacccgcc ttggcctccc aaagtgctgg cattacaggt gtgagccacc gtgcccggcc   1500

accagaatcc tttggtatag ccaagccttt tggttaccgc ctcatgaaga atatgcttcc   1560

cgcattgtcc tagtcccagt tgtattctca caggtgttat gtgcaggaca caatccaaat   1620

cataaacctg gctcatgccc aacacatttc tgctaatagg gagagggacc caccacacac   1680

ccacacatgc cagaggtccc tcctcacaga ggagagggcc tgtgtctgta gaaggttaaa   1740

gctgacaaca tgtgaaacat cccagaatta tgactcttcc caagtttaaa atacattctc   1800

ctcatgagag cagaaggttt gttgctgtgt tgtgaatgat gagctgcctc catagggaac   1860

ccactgccac ctgggccagc ttctggagca tgagaacctg agccagggtc acccttgtgg   1920

ggcctggaca tgacgcacgc tggctgcgac taggagcagg gctgcctctt ctccctcccc   1980

aaggtctgct tgtgggcacg ctctgttccc tcaggtgcca ttctcccagg gcttaggcgc   2040

ccataaatgt tctttctgtg gtggagtagg gcctcctgct tccatactgt cgcatgggct   2100

agatctcagg tgtggtgttg agccacctta agatgagggc tgcttcgcag taaagtttcc   2160

agcctgggcc cctcttgggc cttctggctg gggaccctca gcctcctgat gctgttgcag   2220

ggcaggtctg agagggtgcc cagcagcacc cggtgtcagg gccaccttgt tttccatttt   2280

tgaacagcgc tccctgtggt ttgtgcccac tgctcaatac agcctccgat cctcactctt   2340

gaaagctcca tgataagcac agagatgggc agtgtgggtc agaaggtggg ccgcttcctg   2400

tggaagaggg aagtgtaggt gaatagatat caaaacccct gatgtcattc ttttgagggg   2460

ttggattttc ttttttctgg cagacatttc agtacattca catttctctc acatttgctg   2520

aatgtgagat cagaataaag gagatcggcg tttatttcgt aaaaaaaaaa aaaaaaaa     2578


<210>  3327
<211>  193
<212>  PRT
<213>  Homosapiens

<400>  3327

Met Ile Gln Ala Ile Leu Val Phe Asn Asn His Gly Lys Pro Arg Leu 
1               5                   10                  15      


Val Arg Phe Tyr Gln Arg Phe Pro Glu Glu Ile Gln Gln Gln Ile Val 
            20                  25                  30          


Arg Glu Thr Phe His Leu Val Leu Lys Arg Asp Asp Asn Ile Cys Asn 
        35                  40                  45              


Phe Leu Glu Gly Gly Ser Leu Ile Gly Gly Ser Asp Tyr Lys Leu Ile 
    50                  55                  60                  


Tyr Arg His Tyr Ala Thr Leu Tyr Phe Val Phe Cys Val Asp Ser Ser 
65                  70                  75                  80  


Glu Ser Glu Leu Gly Ile Leu Asp Leu Ile Gln Val Phe Val Glu Thr 
                85                  90                  95      


Leu Asp Lys Cys Phe Glu Asn Val Cys Glu Leu Asp Leu Ile Phe His 
            100                 105                 110         


Met Asp Lys Val His Tyr Ile Leu Gln Glu Val Val Met Gly Gly Met 
        115                 120                 125             


Val Leu Glu Thr Asn Met Asn Glu Ile Val Ala Gln Ile Glu Ala Gln 
    130                 135                 140                 


Asn Arg Leu Glu Lys Ser Glu Gly Gly Leu Ser Ala Ala Pro Ala Arg 
145                 150                 155                 160 


Ala Val Ser Ala Val Lys Asn Ile Asn Leu Pro Glu Ile Pro Arg Asn 
                165                 170                 175     


Ile Asn Ile Gly Asp Leu Asn Ile Lys Val Pro Asn Leu Ser Gln Phe 
            180                 185                 190         


Val 
    


<210>  3328
<211>  2065
<212>  DNA
<213>  Homosapiens

<400>  3328
cgcgggtccc cgcgcgtcct gcagcacttc ccgcgccgcg cccccagccc agtgcgccgg     60

ctctgtgccg gggtgcccgg gcggtcggga gaatgagccg catctaccac gacggcgcgc    120

tccggaacaa ggcggtgcag agcgtccggc tgccaggggc ctgggacccc gccgcccacc    180

aggggggaaa tggtgtcctg ctggagggag aactgatcga tgtatctcgg cacagcatct    240

tggacactca tggcaggaag gagcgctact acgtgctgta tatccggccc agtcacatcc    300

atcgccgtaa attcgacgcc aagggaaatg aaatcgagcc caacttcagc gccaccagga    360

aggtgaacac gggcttcctc atgtcgtcct acaaggtgga agccaagggg gacactgaca    420

ggctcacgcc cgaggcgctg aaggggctgg tcaacaagcc agagctgctc gcgctgacag    480

agagcctcac ccccgaccac acagtggcgt tctggatgcc cgagtcagag atggaggtga    540

tggaactcga gctgggggcc ggggtacggc tgaagactcg gggcgatggt cccttcctgg    600

attcattggc caaacttgag gctggaacag tgaccaagtg taatttcact ggtgatggaa    660

agacaggggc atcctggaca gacaacatca tggcccaaaa gtgttcgaag ggggctgcag    720

cggagatccg agagcagggg gatggggcag aggacgagga gtgggatgac tgagggacgt    780

ggctgcctct gggggcacca gcaccttctg tagcattgtg gaacatttct tccatgaact    840

tctactctgg agctggagag aacagtctgc caagtcttac ctggttcttc cccatagcca    900

ccttggaata ctctttgaac aagctctgct aaaaccaaac ccatgaccac tgtgttggtg    960

gtggggcctc atgctgtggc tcagggaggg cccctccctg catgtgagtc tagccttcct   1020

agacattaca tgatgaccct ttaaaaaaaa attagagatg gaggtctcac tgtgttgccc   1080

aggctgatct cgaactcctg gactcaagcg atccacccac ctccacctcc caaggtgttg   1140

ggattacagg cgtgagccac cgcacccagc ctcatgttga ccctggccct ggatagcagc   1200

tttgtttgta gaggcaggtg gtgggagaga ccctaggaca gcctgagagt aactggacct   1260

ggtattggtg cggagtgggg aatatccctt gtctaaatgc agagcagctg agagaagtta   1320

gcggggctct tcctccgttc tcattgtttc ctgctttcct tccccaccca ccccttcctc   1380

agcactctgt gttgtagcct gtactatcct gcttcaagcc tccgtgtccc ttgtaccttc   1440

cccctacctt gagttgccag ttctttactc cctcaaatgt tcccatgcca cctctggggt   1500

ttctgttatc tgacatccct ggctgctttc ctggtagatg ccattcccag agaggccaac   1560

agcgttccca ggcgtggctg gctggtccgc atctctcaga ctcactctgc caggctacag   1620

ttttgagaat accttttttg ttgttgtttt gtacctggag aactttttat gaatgagtaa   1680

atcttcagaa aggaattcct ccacccttac tgggttattg tcaggtgtaa acggcctttc   1740

agctgagcaa tgttcctatg agaaggaagc catttctctt ggctcatgaa cactgccttt   1800

tgggtagtat acccacaccc agatctgtga agagacctgg aattgaagtc tccatgtcgt   1860

caggacttgg tggcatgtgg atcttgcttg acttgggaaa agagagggtg gtggtgaact   1920

aataattatg gagtccccct aatgtgtcga acacaatgct agatgattaa aaaaaaaaaa   1980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2040

aaaaaaaaaa aaaaaaaaaa aaaaa                                         2065


<210>  3329
<211>  226
<212>  PRT
<213>  Homosapiens

<400>  3329

Met Ser Arg Ile Tyr His Asp Gly Ala Leu Arg Asn Lys Ala Val Gln 
1               5                   10                  15      


Ser Val Arg Leu Pro Gly Ala Trp Asp Pro Ala Ala His Gln Gly Gly 
            20                  25                  30          


Asn Gly Val Leu Leu Glu Gly Glu Leu Ile Asp Val Ser Arg His Ser 
        35                  40                  45              


Ile Leu Asp Thr His Gly Arg Lys Glu Arg Tyr Tyr Val Leu Tyr Ile 
    50                  55                  60                  


Arg Pro Ser His Ile His Arg Arg Lys Phe Asp Ala Lys Gly Asn Glu 
65                  70                  75                  80  


Ile Glu Pro Asn Phe Ser Ala Thr Arg Lys Val Asn Thr Gly Phe Leu 
                85                  90                  95      


Met Ser Ser Tyr Lys Val Glu Ala Lys Gly Asp Thr Asp Arg Leu Thr 
            100                 105                 110         


Pro Glu Ala Leu Lys Gly Leu Val Asn Lys Pro Glu Leu Leu Ala Leu 
        115                 120                 125             


Thr Glu Ser Leu Thr Pro Asp His Thr Val Ala Phe Trp Met Pro Glu 
    130                 135                 140                 


Ser Glu Met Glu Val Met Glu Leu Glu Leu Gly Ala Gly Val Arg Leu 
145                 150                 155                 160 


Lys Thr Arg Gly Asp Gly Pro Phe Leu Asp Ser Leu Ala Lys Leu Glu 
                165                 170                 175     


Ala Gly Thr Val Thr Lys Cys Asn Phe Thr Gly Asp Gly Lys Thr Gly 
            180                 185                 190         


Ala Ser Trp Thr Asp Asn Ile Met Ala Gln Lys Cys Ser Lys Gly Ala 
        195                 200                 205             


Ala Ala Glu Ile Arg Glu Gln Gly Asp Gly Ala Glu Asp Glu Glu Trp 
    210                 215                 220                 


Asp Asp 
225     


<210>  3330
<211>  3082
<212>  DNA
<213>  Homosapiens

<400>  3330
agcagcagcc cgggcggtgg gcagccagga gcccccggcc cggcccggcc cggcccgccg     60

agggccccag cgcaggagcc gcgcccggac ccaggcgatg ccctcctagc tagccgtcac    120

gggatggagg gcttcatgga ctcagggaca cagacggacg ccgtggtggt gctgtccttg    180

gctcaggccg ccgtgcttgg cctggtctcc gaaaatgagc tctttggagc taccataagc    240

gccgaggcct tctacccgga cctggggccc gagctttcag gggcagccat gggagagccc    300

gagccaccag gccccgacgt ctaccagctg gcctgcaacg ggagggcctt ggaggagccg    360

gcggaggagg aggtgctgga ggtggaggca gcctgtgaga agcacacccg gcggaagacg    420

cggccacctg tgcggttggt gcccaaggtc aagttcgaga aggtggagga ggaggaacag    480

gaggtctatg aggtttctgt gccaggtgac gacaaggacg cagggccagc agaagccccc    540

gccgaggcgg ccagtggcgg ctgcgacgcc ctggtgcaga gcagcgccgt caagatgatc    600

gacctcagcg ccttcagccg caagccccgg acgctccggc atctgccccg aaccccgagg    660

ccggagctga acgtggcccc atatgaccct cacttcccgg ccccggcccg ggatggcttc    720

cccgagccca gcatggcgct gcctgggcca gaggccttgc ccacagagtg tgggttcgag    780

ccaccccacc tggcccccct gagtgacccc gaggccccca gcatggagtc cccggagcct    840

gtcaagccgg aacagggctt cgtgtggcag gaggccagtg agttcgaggc tgacacggcg    900

ggttcgaccg tggaacgcca caagaaggcc cagctggatc ggctggacat caacgtgcag    960

attgacgact cctatctggt ggaggcgggc gaccgccaga agcgctggca gtgccgcatg   1020

tgcgagaagt cctacacgtc caagtacaac ctggtgacgc acatcctggg ccacaacggc   1080

atcaagccac actcgtgccc acactgcagc aagctcttca agcagcccag ccacctgcag   1140

acgcacctgc tgacgcacca gggcacccgg ccccacaagt gccaggtatg ccacaaggcc   1200

ttcacgcaga ccagccacct caagcgccac atgctgctgc actcggaggt caagccctac   1260

agctgccact tctgcggccg cggcttcgcc taccccagcg agctcaaggc ccacgaagtg   1320

aagcatgaga gtggccgctg ccatgtctgc gtcgagtgcg gcctggactt ctccaccctg   1380

acccagctca agcgccacct ggcctcccac cagggcccca ccctctacca gtgcctcgag   1440

tgtgacaagt ccttccacta ccgcagccag ttgcagaacc acatgctcaa gcaccagaac   1500

gtgcgaccct tcgtgtgcac tgaatgcggc atggagttca gccagattca ccacctcaag   1560

cagcactccc tcacccacaa gggcgtgaag gagttcaagt gcgaggtgtg tggccgggag   1620

ttcaccctac aggcgaacat gaagcggcac atgctgatcc acaccagcgt ccggccctac   1680

cagtgccaca tctgcttcaa gacctttgta cagaagcaga ctctcaagac ccacatgatt   1740

gtacactcgc ccgtgaagcc attcaaatgc aaggtgtgcg ggaagtcctt caaccgcatg   1800

tacaacctgc tgggccacat gcacctgcac gccggcagca agcccttcaa gtgcccctac   1860

tgctccagca agtttaatct caagggcaac ctgagccggc acatgaaggt caagcatggc   1920

gtcatagaca tcggcctgga cagccaagac cccatgatgg agctgacagg cactgaccct   1980

tcagagctcg acggccagca ggagatggag gacttcgagg agaacgccta cagctatgcg   2040

agcgtggaca gcagcgccga ggccagtgtc ctcactgaac aggccatgaa agagatggcc   2100

tactacaatg tgctatagcg caagctgggc cacccctaac gggggccggg ggcgagggca   2160

tgggggtgag acccatgggc tgcaggctgc acctcctgca gccgagaaac aagctactgc   2220

cccactgttc tgagccctcc ctccccgagt catttgcacc actagggacc tttagaccaa   2280

atggagactg tactactggc cccggctgtg agccagcaca ggcccaggca tcccagcaag   2340

ggaaggagag cacgcgaggc ccagatctgg gtctccctgg cctgcttccg tggggagtgg   2400

gagaagtggg gccactgggg acaggtcaca agggcaccgg ccctcggggt ctctccaggc   2460

ccagcagagc tcttcagggg tcctgacact ggaagaagag accacttgag ccatgtcttt   2520

ttcacggcca actcctgcct ctaaggatgt ctgagctccc ctctggccag tactgcccac   2580

ctctaccttg tccaggcccc cttccccgcc ctgtcgacgg accgccaggc agggcactct   2640

gccttctacc tcccggggtc tcccatgcgc tcctcaagcc aggtgtgcac gtggccctgg   2700

ccctggcctg caggacagct ggggggcacc cagcccccag aagacccctg tcctacatcc   2760

ctttctggaa gtgagtgtcc ctacagtgga ttgcaacaca tgtcgtccac ttcgacccta   2820

gctggagtgc ctcaccaggg ggccccacta ggaacaaagc caggacaggc cccgcgtcag   2880

gcacacacta acaaaaccag aagcatgggg cagggcaggg cggagtgagg gcatcacagg   2940

ggaccaagaa gggctgtcct tgggggaggc ccaggaccac ctgtcgggga gggggaccgc   3000

agtcatttct cattcctcag tgtccacctt gcgacgggga tagccacgag tcagcagctt   3060

cccggaaaga gcaacgtatt tt                                            3082


<210>  3331
<211>  664
<212>  PRT
<213>  Homosapiens

<400>  3331

Met Glu Gly Phe Met Asp Ser Gly Thr Gln Thr Asp Ala Val Val Val 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ala Ala Val Leu Gly Leu Val Ser Glu Asn Glu 
            20                  25                  30          


Leu Phe Gly Ala Thr Ile Ser Ala Glu Ala Phe Tyr Pro Asp Leu Gly 
        35                  40                  45              


Pro Glu Leu Ser Gly Ala Ala Met Gly Glu Pro Glu Pro Pro Gly Pro 
    50                  55                  60                  


Asp Val Tyr Gln Leu Ala Cys Asn Gly Arg Ala Leu Glu Glu Pro Ala 
65                  70                  75                  80  


Glu Glu Glu Val Leu Glu Val Glu Ala Ala Cys Glu Lys His Thr Arg 
                85                  90                  95      


Arg Lys Thr Arg Pro Pro Val Arg Leu Val Pro Lys Val Lys Phe Glu 
            100                 105                 110         


Lys Val Glu Glu Glu Glu Gln Glu Val Tyr Glu Val Ser Val Pro Gly 
        115                 120                 125             


Asp Asp Lys Asp Ala Gly Pro Ala Glu Ala Pro Ala Glu Ala Ala Ser 
    130                 135                 140                 


Gly Gly Cys Asp Ala Leu Val Gln Ser Ser Ala Val Lys Met Ile Asp 
145                 150                 155                 160 


Leu Ser Ala Phe Ser Arg Lys Pro Arg Thr Leu Arg His Leu Pro Arg 
                165                 170                 175     


Thr Pro Arg Pro Glu Leu Asn Val Ala Pro Tyr Asp Pro His Phe Pro 
            180                 185                 190         


Ala Pro Ala Arg Asp Gly Phe Pro Glu Pro Ser Met Ala Leu Pro Gly 
        195                 200                 205             


Pro Glu Ala Leu Pro Thr Glu Cys Gly Phe Glu Pro Pro His Leu Ala 
    210                 215                 220                 


Pro Leu Ser Asp Pro Glu Ala Pro Ser Met Glu Ser Pro Glu Pro Val 
225                 230                 235                 240 


Lys Pro Glu Gln Gly Phe Val Trp Gln Glu Ala Ser Glu Phe Glu Ala 
                245                 250                 255     


Asp Thr Ala Gly Ser Thr Val Glu Arg His Lys Lys Ala Gln Leu Asp 
            260                 265                 270         


Arg Leu Asp Ile Asn Val Gln Ile Asp Asp Ser Tyr Leu Val Glu Ala 
        275                 280                 285             


Gly Asp Arg Gln Lys Arg Trp Gln Cys Arg Met Cys Glu Lys Ser Tyr 
    290                 295                 300                 


Thr Ser Lys Tyr Asn Leu Val Thr His Ile Leu Gly His Asn Gly Ile 
305                 310                 315                 320 


Lys Pro His Ser Cys Pro His Cys Ser Lys Leu Phe Lys Gln Pro Ser 
                325                 330                 335     


His Leu Gln Thr His Leu Leu Thr His Gln Gly Thr Arg Pro His Lys 
            340                 345                 350         


Cys Gln Val Cys His Lys Ala Phe Thr Gln Thr Ser His Leu Lys Arg 
        355                 360                 365             


His Met Leu Leu His Ser Glu Val Lys Pro Tyr Ser Cys His Phe Cys 
    370                 375                 380                 


Gly Arg Gly Phe Ala Tyr Pro Ser Glu Leu Lys Ala His Glu Val Lys 
385                 390                 395                 400 


His Glu Ser Gly Arg Cys His Val Cys Val Glu Cys Gly Leu Asp Phe 
                405                 410                 415     


Ser Thr Leu Thr Gln Leu Lys Arg His Leu Ala Ser His Gln Gly Pro 
            420                 425                 430         


Thr Leu Tyr Gln Cys Leu Glu Cys Asp Lys Ser Phe His Tyr Arg Ser 
        435                 440                 445             


Gln Leu Gln Asn His Met Leu Lys His Gln Asn Val Arg Pro Phe Val 
    450                 455                 460                 


Cys Thr Glu Cys Gly Met Glu Phe Ser Gln Ile His His Leu Lys Gln 
465                 470                 475                 480 


His Ser Leu Thr His Lys Gly Val Lys Glu Phe Lys Cys Glu Val Cys 
                485                 490                 495     


Gly Arg Glu Phe Thr Leu Gln Ala Asn Met Lys Arg His Met Leu Ile 
            500                 505                 510         


His Thr Ser Val Arg Pro Tyr Gln Cys His Ile Cys Phe Lys Thr Phe 
        515                 520                 525             


Val Gln Lys Gln Thr Leu Lys Thr His Met Ile Val His Ser Pro Val 
    530                 535                 540                 


Lys Pro Phe Lys Cys Lys Val Cys Gly Lys Ser Phe Asn Arg Met Tyr 
545                 550                 555                 560 


Asn Leu Leu Gly His Met His Leu His Ala Gly Ser Lys Pro Phe Lys 
                565                 570                 575     


Cys Pro Tyr Cys Ser Ser Lys Phe Asn Leu Lys Gly Asn Leu Ser Arg 
            580                 585                 590         


His Met Lys Val Lys His Gly Val Ile Asp Ile Gly Leu Asp Ser Gln 
        595                 600                 605             


Asp Pro Met Met Glu Leu Thr Gly Thr Asp Pro Ser Glu Leu Asp Gly 
    610                 615                 620                 


Gln Gln Glu Met Glu Asp Phe Glu Glu Asn Ala Tyr Ser Tyr Ala Ser 
625                 630                 635                 640 


Val Asp Ser Ser Ala Glu Ala Ser Val Leu Thr Glu Gln Ala Met Lys 
                645                 650                 655     


Glu Met Ala Tyr Tyr Asn Val Leu 
            660                 


<210>  3332
<211>  1740
<212>  DNA
<213>  Homosapiens

<400>  3332
ccagcgttag cccgcggcca ggcagccggg aggagcggcg cgcgctcgga cctctcccgc     60

cctgctcgtt cgctctccag cttgggatgg ccggctacct gcgggtcgtg cgctcgctct    120

gcagagcctc aggctcgcgg ccggcctggg cgccggcggc cctgacagcc cccacctcgc    180

aagagcagcc gcggcgccac tatgccgaca aaaggatcaa ggtggcgaag cccgtggtgg    240

agatggatgg tgatgagatg acccgtatta tctggcagtt catcaaggag aagctcatcc    300

tgccccacgt ggacatccag ctaaagtatt ttgacctcgg gctcccaaac cgtgaccaga    360

ctgatgacca ggtcaccatt gactctgcac tggccaccca gaagtacagt gtggctgtca    420

agtgtgccac catcacccct gatgaggccc gtgtggaaga gttcaagctg aagaagatgt    480

ggaaaagtcc caatggaact atccggaaca tcctgggggg gactgtcttc cgggagccca    540

tcatctgcaa aaacatccca cgcctagtcc ctggctggac caagcccatc accattggca    600

ggcacgccca tggcgaccag tacaaggcca cagactttgt ggcagaccgg gccggcactt    660

tcaaaatggt cttcacccca aaagatggca gtggtgtcaa ggagtgggaa gtgtacaact    720

tccccgcagg cggcgtgggc atgggcatgt acaacaccga cgagtccatc tcaggttttg    780

cgcacagctg cttccagtat gccatccaga agaaatggcc gctgtacatg agcaccaaga    840

acaccatact gaaagcctac gatgggcgtt tcaaggacat cttccaggag atctttgaca    900

agcactataa gaccgacttc gacaagaata agatctggta tgagcaccgg ctcattgatg    960

acatggtggc tcaggtcctc aagtcttcgg gtggctttgt gtgggcctgc aagaactatg   1020

acggagatgt gcagtcagac atcctggccc agggctttgg ctcccttggc ctgatgacgt   1080

ccgtcctggt ctgccctgat gggaagacga ttgaggctga ggccgctcat gggaccgtca   1140

cccgccacta tcgggagcac cagaagggcc ggcccaccag caccaacccc atcgccagca   1200

tctttgcctg gacacgtggc ctggagcacc gggggaagct ggatgggaac caagacctca   1260

tcaggtttgc ccagatgctg gagaaggtgt gcgtggagac ggtggagagt ggagccatga   1320

ccaaggacct ggcgggctgc attcacggcc tcagcaatgt gaagctgaac gagcacttcc   1380

tgaacaccac ggacttcctc gacaccatca agagcaacct ggacagagcc ctgggcaggc   1440

agtaggggga ggcgccaccc atggctgcag tggaggggcc agggctgagc cggcgggtcc   1500

tcctgagcgc ggcagagggt gagcctcaca gcccctctct ggaggccttt ctaggggatg   1560

tttttttata agccagatgt ttttaaaagc atatgtgtgt ttcccctcat ggtgacgtga   1620

ggcaggagca gtgcgtttta cctcagccag tcagtatgtt ttgcatactg taatttatat   1680

tgcccttgga acacatggtg ccatatttag ctactaaaaa gctcttcaca aaaaaaaaaa   1740


<210>  3333
<211>  452
<212>  PRT
<213>  Homosapiens

<400>  3333

Met Ala Gly Tyr Leu Arg Val Val Arg Ser Leu Cys Arg Ala Ser Gly 
1               5                   10                  15      


Ser Arg Pro Ala Trp Ala Pro Ala Ala Leu Thr Ala Pro Thr Ser Gln 
            20                  25                  30          


Glu Gln Pro Arg Arg His Tyr Ala Asp Lys Arg Ile Lys Val Ala Lys 
        35                  40                  45              


Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln 
    50                  55                  60                  


Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Ile Gln Leu Lys 
65                  70                  75                  80  


Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asp Asp Gln Val 
                85                  90                  95      


Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys 
            100                 105                 110         


Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu 
        115                 120                 125             


Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly 
    130                 135                 140                 


Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu 
145                 150                 155                 160 


Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly 
                165                 170                 175     


Asp Gln Tyr Lys Ala Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe 
            180                 185                 190         


Lys Met Val Phe Thr Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu 
        195                 200                 205             


Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr 
    210                 215                 220                 


Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ala Ile 
225                 230                 235                 240 


Gln Lys Lys Trp Pro Leu Tyr Met Ser Thr Lys Asn Thr Ile Leu Lys 
                245                 250                 255     


Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys 
            260                 265                 270         


His Tyr Lys Thr Asp Phe Asp Lys Asn Lys Ile Trp Tyr Glu His Arg 
        275                 280                 285             


Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe 
    290                 295                 300                 


Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu 
305                 310                 315                 320 


Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys 
                325                 330                 335     


Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr 
            340                 345                 350         


Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro 
        355                 360                 365             


Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys 
    370                 375                 380                 


Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Met Leu Glu Lys 
385                 390                 395                 400 


Val Cys Val Glu Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala 
                405                 410                 415     


Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu 
            420                 425                 430         


Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala 
        435                 440                 445             


Leu Gly Arg Gln 
    450         


<210>  3334
<211>  1790
<212>  DNA
<213>  Homosapiens

<400>  3334
ccggtcgggt tctgggaggc accgcctcgg ggttgcgggc cgggtgcggc tcggcggtgg     60

aggactcact tcctgctcca tccccggctg ggccctgggg cggaactgat gacgcttgat    120

aatgtggctg gggacttcag ggaagagtgg gttacctgga cactgcttag agaatcctct    180

ccaggaatgc cacccagcac agttagaaga atgggctctc aaaggaattt ccaggcctag    240

tgtaatctcc cagccggagc agaaagaaga gccatgggtc ctaccactcc aaaactttga    300

ggcgaggaag atcccgaggg aaagccacac agactgtgag catcaggtgg caaagctcaa    360

tcaggacagt tctgaaacag cagaacaatg tggaacatcc tcagaaagga ccaataaaga    420

tctttctcat actcttagtt ggggaggaaa ctgggagcaa ggcctagaat tagaagggca    480

acatggaacc cttccaggag agggccagct ggagtccttt tcacaggaga gggatttaaa    540

caagctcctg gatggatatg taggagagaa gcctatgtgt gcagaatgcg ggaaaagctt    600

taaccagagt tcctatctca taagacacct aagaacccac actggcgaga ggccctatac    660

gtgcattgag tgtgggaaag gcttcaaaca gagctcagac cttgtcaccc atcgcagaac    720

acacacagga gagaagccct accaatgcaa ggggtgtgag aagaaattca gcgacagctc    780

aacactcatc aaacatcaga gaacccacac aggggagaga ccctatgagt gcccagagtg    840

tggaaagact tttgggcgga agccacacct cataatgcac caaagaaccc acacaggcga    900

gaagccctac gcgtgcctgg aatgtcacaa aagcttcagt cgaagctcaa atttcatcac    960

tcaccagagg acccacacag gggtgaagcc ttacaggtgt aatgactgtg gggagagttt   1020

tagccagagc tcggatttga ttaagcacca acgaacccac acgggagaac ggcccttcaa   1080

atgcccggag tgcgggaagg gcttcagaga tagttctcat tttgtagctc acatgagcac   1140

tcattcagga gagaggcctt tcagttgtcc tgactgccac aaaagcttca gtcagagctc   1200

acatttggtc acgcaccaaa gaacacacac aggtgagaga ccttttaagt gcgaaaactg   1260

tgggaaagga ttcgccgaca gctccgccct cattaagcac caacgaatcc acaccggaga   1320

aagaccctac aaatgtggag agtgtgggaa gagcttcaat cagagctccc actttattac   1380

ccatcagcga atccacttag gagacaggcc ctatcgatgt cctgagtgtg gcaagacctt   1440

caatcagcgt tcccatttcc tcacacacca gagaacgcat acaggagaaa aacctttcca   1500

ctgtagtaaa tgtaacaaga gcttccgtca gaaagcgcat cttttatgcc atcaaaacac   1560

ccatttgatt taggaagtag tctttggtgt tcagctgctc ccttgcacat tttcattgct   1620

actgtcttca agcaccccaa atagagaaaa cctgggcgtc agtggctcaa tttgggccct   1680

gatctattct ccctctttct tgtctatgtt ataacagaga ggataaactt aaagggtcca   1740

aataacggtc cgaatacaaa aggcattcct tcaaaaaaaa aaaaaaaaaa              1790


<210>  3335
<211>  483
<212>  PRT
<213>  Homosapiens

<400>  3335

Met Trp Leu Gly Thr Ser Gly Lys Ser Gly Leu Pro Gly His Cys Leu 
1               5                   10                  15      


Glu Asn Pro Leu Gln Glu Cys His Pro Ala Gln Leu Glu Glu Trp Ala 
            20                  25                  30          


Leu Lys Gly Ile Ser Arg Pro Ser Val Ile Ser Gln Pro Glu Gln Lys 
        35                  40                  45              


Glu Glu Pro Trp Val Leu Pro Leu Gln Asn Phe Glu Ala Arg Lys Ile 
    50                  55                  60                  


Pro Arg Glu Ser His Thr Asp Cys Glu His Gln Val Ala Lys Leu Asn 
65                  70                  75                  80  


Gln Asp Ser Ser Glu Thr Ala Glu Gln Cys Gly Thr Ser Ser Glu Arg 
                85                  90                  95      


Thr Asn Lys Asp Leu Ser His Thr Leu Ser Trp Gly Gly Asn Trp Glu 
            100                 105                 110         


Gln Gly Leu Glu Leu Glu Gly Gln His Gly Thr Leu Pro Gly Glu Gly 
        115                 120                 125             


Gln Leu Glu Ser Phe Ser Gln Glu Arg Asp Leu Asn Lys Leu Leu Asp 
    130                 135                 140                 


Gly Tyr Val Gly Glu Lys Pro Met Cys Ala Glu Cys Gly Lys Ser Phe 
145                 150                 155                 160 


Asn Gln Ser Ser Tyr Leu Ile Arg His Leu Arg Thr His Thr Gly Glu 
                165                 170                 175     


Arg Pro Tyr Thr Cys Ile Glu Cys Gly Lys Gly Phe Lys Gln Ser Ser 
            180                 185                 190         


Asp Leu Val Thr His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr Gln 
        195                 200                 205             


Cys Lys Gly Cys Glu Lys Lys Phe Ser Asp Ser Ser Thr Leu Ile Lys 
    210                 215                 220                 


His Gln Arg Thr His Thr Gly Glu Arg Pro Tyr Glu Cys Pro Glu Cys 
225                 230                 235                 240 


Gly Lys Thr Phe Gly Arg Lys Pro His Leu Ile Met His Gln Arg Thr 
                245                 250                 255     


His Thr Gly Glu Lys Pro Tyr Ala Cys Leu Glu Cys His Lys Ser Phe 
            260                 265                 270         


Ser Arg Ser Ser Asn Phe Ile Thr His Gln Arg Thr His Thr Gly Val 
        275                 280                 285             


Lys Pro Tyr Arg Cys Asn Asp Cys Gly Glu Ser Phe Ser Gln Ser Ser 
    290                 295                 300                 


Asp Leu Ile Lys His Gln Arg Thr His Thr Gly Glu Arg Pro Phe Lys 
305                 310                 315                 320 


Cys Pro Glu Cys Gly Lys Gly Phe Arg Asp Ser Ser His Phe Val Ala 
                325                 330                 335     


His Met Ser Thr His Ser Gly Glu Arg Pro Phe Ser Cys Pro Asp Cys 
            340                 345                 350         


His Lys Ser Phe Ser Gln Ser Ser His Leu Val Thr His Gln Arg Thr 
        355                 360                 365             


His Thr Gly Glu Arg Pro Phe Lys Cys Glu Asn Cys Gly Lys Gly Phe 
    370                 375                 380                 


Ala Asp Ser Ser Ala Leu Ile Lys His Gln Arg Ile His Thr Gly Glu 
385                 390                 395                 400 


Arg Pro Tyr Lys Cys Gly Glu Cys Gly Lys Ser Phe Asn Gln Ser Ser 
                405                 410                 415     


His Phe Ile Thr His Gln Arg Ile His Leu Gly Asp Arg Pro Tyr Arg 
            420                 425                 430         


Cys Pro Glu Cys Gly Lys Thr Phe Asn Gln Arg Ser His Phe Leu Thr 
        435                 440                 445             


His Gln Arg Thr His Thr Gly Glu Lys Pro Phe His Cys Ser Lys Cys 
    450                 455                 460                 


Asn Lys Ser Phe Arg Gln Lys Ala His Leu Leu Cys His Gln Asn Thr 
465                 470                 475                 480 


His Leu Ile 
            


<210>  3336
<211>  7219
<212>  DNA
<213>  Homosapiens

<400>  3336
ggaccccggc aagcccgcgc acttggcagg agctgtagct accgccgtcc gcgcctccaa     60

ggtttcacgg cttcctcagc agagactcgg gctcgtccgc catgtccgcc gcagacgagg    120

ttgacgggct gggcgtggcc cggccgcact atggctctgt cctggataat gaaagactta    180

ctgcagagga gatggatgaa aggagacgtc agaacgtggc ttatgagtac ctttgtcatt    240

tggaagaagc gaagaggtgg atggaagcat gcctagggga agatctgcct cccaccacag    300

aactggagga ggggcttagg aatggggtct accttgccaa actggggaac ttcttctctc    360

ccaaagtagt gtccctgaaa aaaatctatg atcgagaaca gaccagatac aaggcgactg    420

gcctccactt tagacacact gataatgtga ttcagtggtt gaatgccatg gatgagattg    480

gattgcctaa gattttttac ccagaaacta cagatatcta tgatcgaaag aacatgccaa    540

gatgtatcta ctgtatccat gcactcagtt tgtacctgtt caagctaggc ctggcccctc    600

agattcaaga cctatatgga aaggttgact tcacagaaga agaaatcaac aacatgaaga    660

ctgagttgga gaagtatggc atccagatgc ctgcctttag caagattggg ggcatcttgg    720

ctaatgaact gtcagtggat gaagccgcat tacatgctgc tgttattgct attaatgaag    780

ctattgaccg tagaattcca gccgacacat ttgcagcttt gaaaaatccg aatgccatgc    840

ttgtaaatct tgaagagccc ttggcatcca cttaccagga tatactttac caggctaagc    900

aggacaaaat gacaaatgct aaaaacagga cagaaaactc agagagagaa agagatgttt    960

atgaggagct gctcacgcaa gctgaaattc aaggcaatat aaacaaagtc aatacatttt   1020

ctgcattagc aaatatcgac ctggctttag aacaaggaga tgcactggcc ttgttcaggg   1080

ctctgcagtc accagccctg gggcttcgag gactgcagca acagaatagc gactggtact   1140

tgaagcagct cctgagtgat aaacagcaga agagacagag tggtcagact gaccccctgc   1200

agaaggagga gctgcagtct ggagtggatg ctgcaaacag tgctgcccag caatatcaga   1260

gaagattggc agcagtagca ctgattaatg ctgcaatcca gaagggtgtt gctgagaaga   1320

ctgttttgga actgatgaat cccgaagccc agctgcccca ggtgtatcca tttgccgccg   1380

atctctatca gaaggagctg gctaccctgc agcgacaaag tcctgaacat aatctcaccc   1440

acccagagct ctctgtcgca gtggagatgt tgtcatcggt ggccctgatc aacagggcat   1500

tggaatcagg agatgtgaat acagtgtgga agcaattgag cagttcagtt actggtctta   1560

ccaatattga ggaagaaaac tgtcagaggt atctcgatga gttgatgaaa ctgaaggctc   1620

aggcacatgc agagaataat gaattcatta catggaatga tatccaagct tgcgtggacc   1680

atgtgaacct ggtggtgcaa gaggaacatg agaggatttt agccattggt ttaattaatg   1740

aagccctgga tgaaggtgat gcccaaaaga ctctgcaggc cctacagatt cctgcagcta   1800

aacttgaggg agtccttgca gaagtggccc agcattacca agacacgctg attagagcga   1860

agagagagaa agcccaggaa atccaggatg agtcagctgt gttatggttg gatgaaattc   1920

aaggtggaat ctggcagtcc aacaaagaca cccaagaagc acagaagttt gccttaggaa   1980

tctttgccat taatgaggca gtagaaagtg gtgatgttgg caaaacactg agtgcccttc   2040

gctcccctga tgttggcttg tatggagtca tccctgagtg tggtgaaact taccacagtg   2100

atcttgctga agccaagaag aaaaaactgg cagtaggaga taataacagc aagtgggtga   2160

agcactgggt aaaaggtgga tattattatt accacaatct ggagacccag gaaggaggat   2220

gggatgaacc tccaaatttt gtgcaaaatt ctatgcagct ttctcgggag gagatccaga   2280

gttctatctc tggggtgact gccgcatata accgagaaca gctgtggctg gccaatgaag   2340

gcctgatcac caggctgcag gctcgctgcc gtggatactt agttcgacag gaattccgat   2400

ccaggatgaa tttcctgaag aaacaaatcc ctgccatcac ctgcattcag tcacagtgga   2460

gaggatacaa gcagaagaag gcatatcaag atcggttagc ttacctgcgc tcccacaaag   2520

atgaagttgt aaagattcag tccctggcaa ggatgcacca agctcgaaag cgctatcgag   2580

atcgcctgca gtacttccgg gaccatataa atgacattat caaaatccag gcttttattc   2640

gggcaaacaa agctcgggat gactacaaga ctctcatcaa tgctgaggat cctcctatgg   2700

ttgtggtccg aaaatttgtc cacctgctgg accaaagtga ccaggatttt caggaggagc   2760

ttgaccttat gaagatgcgg gaagaggtta tcaccctcat tcgttctaac cagcagctgg   2820

agaatgacct caatctcatg gatatcaaaa ttggactgct agtgaaaaat aagattacgt   2880

tgcaggatgt ggtttcccac agtaaaaaac ttaccaaaaa aaataaggaa cagttgtctg   2940

atatgatgat gataaataaa cagaagggag gtctcaaggc tttgagcaag gagaagagag   3000

agaagttgga agcttaccag cacctgtttt atttattgca aaccaatccc acctatctgg   3060

ccaagctcat ttttcagatg ccccagaaca agtccaccaa gttcatggac tctgtaatct   3120

tcacactcta caactacgcg tccaaccagc gagaggagta cctgctcctg cggctcttta   3180

agacagcact ccaagaggaa atcaagtcga aggtagatca gattcaagag attgtgacag   3240

gaaatcctac ggttattaaa atggttgtaa gtttcaaccg tggtgcccgt ggccagaatg   3300

ccctgagaca gatcttggcc ccagtcgtga aggaaattat ggatgacaaa tctctcaaca   3360

tcaaaactga ccctgtggat atttacaaat cttgggttaa tcagatggag tctcagacag   3420

gagaggcaag caaactgccc tatgatgtga cccctgagca ggcgctagct catgaagaag   3480

tgaagacacg gctagacagc tccatcagga acatgcgggc tgtgacagac aagtttctct   3540

cagccattgt cagctctgtg gacaaaatcc cttatgggat gcgcttcatt gccaaagtgc   3600

tgaaggactc gttgcatgag aagttccctg atgctggtga ggatgagctg ctgaagatta   3660

ttggtaactt gctttattat cgatacatga atccagccat tgttgctcct gatgcctttg   3720

acatcattga cctgtcagca ggaggccagc ttaccacaga ccaacgccga aatctgggct   3780

ccattgcaaa aatgcttcag catgctgctt ccaataagat gtttctggga gataatgccc   3840

acttaagcat cattaatgaa tatctttccc agtcctacca gaaattcaga cggtttttcc   3900

aaactgcttg tgatgtccca gagcttcagg ataaatttaa tgtggatgag tactctgatt   3960

tagtaaccct caccaaacca gtaatctaca tttccattgg tgaaatcatc aacacccaca   4020

ctctcctgtt ggatcaccag gatgccattg ctccggagca caatgatcca atccacgaac   4080

tgctggacga cctcggcgag gtgcccacca tcgagtccct gataggggaa agctctggca   4140

atttaaatga cccaaataag gaggcactgg ctaagacgga agtgtctctc accctgacca   4200

acaagttcga cgtgcctgga gatgagaatg cagaaatgga tgctcgaacc atcttactga   4260

atacaaaacg tttaattgtg gatgtcatcc ggttccagcc aggagagacc ttgactgaaa   4320

tcctagaaac accagccacc agtgaacagg aagcagaaca tcagagagcc atgcagagac   4380

gtgctatccg tgatgccaaa acacctgaca agatgaaaaa gtcaaaatct gtaaaggaag   4440

acagcaacct cactcttcaa gagaagaaag agaagatcca gacaggttta aagaagctaa   4500

cagagcttgg aaccgtggac ccaaagaaca aataccagga actgatcaac gacattgcca   4560

gggatattcg gaatcagcgg aggtaccgac agaggagaaa ggccgaacta gtgaaactgc   4620

aacagacata cgctgctctg aactctaagg ccacctttta tggggagcag gtggattact   4680

ataaaagcta tatcaaaacc tgcttggata acttagccag caagggcaaa gtctccaaaa   4740

agcctaggga aatgaaagga aagaaaagca aaaagatttc tctgaaatat acagcagcaa   4800

gactacatga aaaaggagtt cttctggaaa ttgaggacct gcaagtgaat cagtttaaaa   4860

atgttatatt tgaaatcagt ccaacagaag aagttggaga cttcgaagtg aaagccaaat   4920

tcatgggagt tcaaatggag acttttatgt tacattatca ggacctgctg cagctacagt   4980

atgaaggagt tgcagtcatg aaattatttg atagagctaa agtaaatgtc aacctcctga   5040

tcttccttct caacaaaaag ttctacggga agtaattgat cgtttgctgc cagcccagaa   5100

ggatgaagga aagaagcacc tcacagctcc tttctaggtc cttctttcct cattggaagc   5160

aaagacctag ccaacaacag cacctcaatc tgatacactc ccgatgccac atttttaact   5220

cctctcgctc tgatgggaca tttgttaccc ttttttcata gtgaaattgt gtttcaggct   5280

tagtctgacc tttctggttt cttcattttc ttccattact taggaaagag tggaaactcc   5340

actaaaattt ctctgtgttg ttacagtctt agaggttgca gtactatatt gtaagctttg   5400

gtgtttgttt aattagcaat agggatggta ggattcaaat gtgtgtcatt tagaagtgga   5460

agctattagc accaatgaca taaatacata caagacacac aactaaaatg tcatgttatt   5520

aacagttatt aggttgtcat ttaaaaataa agttccttta tatttctgtc ccatcaggaa   5580

aactgaagga tatggggaat cattggttat cttccattgt gtttttcttt atggacagga   5640

gctaatggaa gtgacagtca tgttcaaagg aagcatttct agaaaaaagg agataatgtt   5700

tttaaatttc attatcaaac ttgggcaatt ctgtttgtgt aactccccga ctagtggatg   5760

ggagagtccc attgctaaaa ttcagctact cagataaatt cagaatgggt caaggcacct   5820

gcctgttttt gttggtgcac agagattgac ttgattcaga gagacaattc actccatccc   5880

tatggcagag gaatgggtta gccctaatgt agaatgtcat tgtttttaaa actgttttat   5940

atcttaagag tgccttatta aagtatagat gtatgtctta aaatgtgggt gataggaatt   6000

ttaaagattt atataatgca tcaaaagcct tagaataaga aaagcttttt ttaaattgct   6060

ttatctgtat atctgaactc ttgaaactta tagctaaaac actaggattt atctgcagtg   6120

ttcagggaga taattctgcc tttaattgtc taaaacaaaa acaaaaccag ccaacctatg   6180

ttacacgtga gattaaaacc aattttttcc ccattttttc tccttttttc tcttgctgcc   6240

cacattgtgc ctttatttta tgagccccag ttttctgggc ttagtttaaa aaaaaaatca   6300

agtctaaaca ttgcatttag aaagcttttg ttcttggata aaaagtcata cactttaaaa   6360

aaaaaaaaaa ctttttccag gaaaatatat tgaaatcatg ctgctgagcc tctattttct   6420

ttctttgatg ttttgattca gtattctttt atcataaatt tttagcattt aaaaattcac   6480

tgatgtacat taagccaata aactgcttta atgaataaca aactatgtag tgtgtcccta   6540

ttataaatgc attggagaag tatttttatg agactcttta ctcaggtgca tggttacagc   6600

ccacagggag gcatggagtg ccatggaagg attcgccact acccagacct tgttttttgt   6660

tgtattttgg aagacaggtt ttttaaagaa acattttcct cagattaaaa gatgatgcta   6720

ttacaactag cattgcctca aaaactggga ccaaccaaag tgtgtcaacc ctgtttcctt   6780

aaaagaggct atgaatccca aaggccacat ccaagacagg caataatgag cagagtttac   6840

agctccttta ataaaatgtg tcagtaattt taaggtttat agttccctca acacaattgc   6900

taatgcagaa tagtgtaaaa tgcgcttcaa gaatgttgat gatgatgata tagaattgtg   6960

gctttagtag cacagaggat gccccaacaa actcatggcg ttgaaaccac acagttctca   7020

ttactgttat ttattagctg tagcattctc tgtctcctct ctctcctcct ttgaccttct   7080

cctcgaccag ccatcatgac atttaccatg aatttacttc ctcccaagag tttggactgc   7140

ccgtcagatt gttgctgcac atagttgcct ttgtatctct gtatgaaata aaaggtcatt   7200

tgttcatgtt aaaaaaaaa                                                7219


<210>  3337
<211>  1657
<212>  PRT
<213>  Homosapiens

<400>  3337

Met Ser Ala Ala Asp Glu Val Asp Gly Leu Gly Val Ala Arg Pro His 
1               5                   10                  15      


Tyr Gly Ser Val Leu Asp Asn Glu Arg Leu Thr Ala Glu Glu Met Asp 
            20                  25                  30          


Glu Arg Arg Arg Gln Asn Val Ala Tyr Glu Tyr Leu Cys His Leu Glu 
        35                  40                  45              


Glu Ala Lys Arg Trp Met Glu Ala Cys Leu Gly Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Thr Glu Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys 
65                  70                  75                  80  


Leu Gly Asn Phe Phe Ser Pro Lys Val Val Ser Leu Lys Lys Ile Tyr 
                85                  90                  95      


Asp Arg Glu Gln Thr Arg Tyr Lys Ala Thr Gly Leu His Phe Arg His 
            100                 105                 110         


Thr Asp Asn Val Ile Gln Trp Leu Asn Ala Met Asp Glu Ile Gly Leu 
        115                 120                 125             


Pro Lys Ile Phe Tyr Pro Glu Thr Thr Asp Ile Tyr Asp Arg Lys Asn 
    130                 135                 140                 


Met Pro Arg Cys Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe 
145                 150                 155                 160 


Lys Leu Gly Leu Ala Pro Gln Ile Gln Asp Leu Tyr Gly Lys Val Asp 
                165                 170                 175     


Phe Thr Glu Glu Glu Ile Asn Asn Met Lys Thr Glu Leu Glu Lys Tyr 
            180                 185                 190         


Gly Ile Gln Met Pro Ala Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn 
        195                 200                 205             


Glu Leu Ser Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile 
    210                 215                 220                 


Asn Glu Ala Ile Asp Arg Arg Ile Pro Ala Asp Thr Phe Ala Ala Leu 
225                 230                 235                 240 


Lys Asn Pro Asn Ala Met Leu Val Asn Leu Glu Glu Pro Leu Ala Ser 
                245                 250                 255     


Thr Tyr Gln Asp Ile Leu Tyr Gln Ala Lys Gln Asp Lys Met Thr Asn 
            260                 265                 270         


Ala Lys Asn Arg Thr Glu Asn Ser Glu Arg Glu Arg Asp Val Tyr Glu 
        275                 280                 285             


Glu Leu Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn 
    290                 295                 300                 


Thr Phe Ser Ala Leu Ala Asn Ile Asp Leu Ala Leu Glu Gln Gly Asp 
305                 310                 315                 320 


Ala Leu Ala Leu Phe Arg Ala Leu Gln Ser Pro Ala Leu Gly Leu Arg 
                325                 330                 335     


Gly Leu Gln Gln Gln Asn Ser Asp Trp Tyr Leu Lys Gln Leu Leu Ser 
            340                 345                 350         


Asp Lys Gln Gln Lys Arg Gln Ser Gly Gln Thr Asp Pro Leu Gln Lys 
        355                 360                 365             


Glu Glu Leu Gln Ser Gly Val Asp Ala Ala Asn Ser Ala Ala Gln Gln 
    370                 375                 380                 


Tyr Gln Arg Arg Leu Ala Ala Val Ala Leu Ile Asn Ala Ala Ile Gln 
385                 390                 395                 400 


Lys Gly Val Ala Glu Lys Thr Val Leu Glu Leu Met Asn Pro Glu Ala 
                405                 410                 415     


Gln Leu Pro Gln Val Tyr Pro Phe Ala Ala Asp Leu Tyr Gln Lys Glu 
            420                 425                 430         


Leu Ala Thr Leu Gln Arg Gln Ser Pro Glu His Asn Leu Thr His Pro 
        435                 440                 445             


Glu Leu Ser Val Ala Val Glu Met Leu Ser Ser Val Ala Leu Ile Asn 
    450                 455                 460                 


Arg Ala Leu Glu Ser Gly Asp Val Asn Thr Val Trp Lys Gln Leu Ser 
465                 470                 475                 480 


Ser Ser Val Thr Gly Leu Thr Asn Ile Glu Glu Glu Asn Cys Gln Arg 
                485                 490                 495     


Tyr Leu Asp Glu Leu Met Lys Leu Lys Ala Gln Ala His Ala Glu Asn 
            500                 505                 510         


Asn Glu Phe Ile Thr Trp Asn Asp Ile Gln Ala Cys Val Asp His Val 
        515                 520                 525             


Asn Leu Val Val Gln Glu Glu His Glu Arg Ile Leu Ala Ile Gly Leu 
    530                 535                 540                 


Ile Asn Glu Ala Leu Asp Glu Gly Asp Ala Gln Lys Thr Leu Gln Ala 
545                 550                 555                 560 


Leu Gln Ile Pro Ala Ala Lys Leu Glu Gly Val Leu Ala Glu Val Ala 
                565                 570                 575     


Gln His Tyr Gln Asp Thr Leu Ile Arg Ala Lys Arg Glu Lys Ala Gln 
            580                 585                 590         


Glu Ile Gln Asp Glu Ser Ala Val Leu Trp Leu Asp Glu Ile Gln Gly 
        595                 600                 605             


Gly Ile Trp Gln Ser Asn Lys Asp Thr Gln Glu Ala Gln Lys Phe Ala 
    610                 615                 620                 


Leu Gly Ile Phe Ala Ile Asn Glu Ala Val Glu Ser Gly Asp Val Gly 
625                 630                 635                 640 


Lys Thr Leu Ser Ala Leu Arg Ser Pro Asp Val Gly Leu Tyr Gly Val 
                645                 650                 655     


Ile Pro Glu Cys Gly Glu Thr Tyr His Ser Asp Leu Ala Glu Ala Lys 
            660                 665                 670         


Lys Lys Lys Leu Ala Val Gly Asp Asn Asn Ser Lys Trp Val Lys His 
        675                 680                 685             


Trp Val Lys Gly Gly Tyr Tyr Tyr Tyr His Asn Leu Glu Thr Gln Glu 
    690                 695                 700                 


Gly Gly Trp Asp Glu Pro Pro Asn Phe Val Gln Asn Ser Met Gln Leu 
705                 710                 715                 720 


Ser Arg Glu Glu Ile Gln Ser Ser Ile Ser Gly Val Thr Ala Ala Tyr 
                725                 730                 735     


Asn Arg Glu Gln Leu Trp Leu Ala Asn Glu Gly Leu Ile Thr Arg Leu 
            740                 745                 750         


Gln Ala Arg Cys Arg Gly Tyr Leu Val Arg Gln Glu Phe Arg Ser Arg 
        755                 760                 765             


Met Asn Phe Leu Lys Lys Gln Ile Pro Ala Ile Thr Cys Ile Gln Ser 
    770                 775                 780                 


Gln Trp Arg Gly Tyr Lys Gln Lys Lys Ala Tyr Gln Asp Arg Leu Ala 
785                 790                 795                 800 


Tyr Leu Arg Ser His Lys Asp Glu Val Val Lys Ile Gln Ser Leu Ala 
                805                 810                 815     


Arg Met His Gln Ala Arg Lys Arg Tyr Arg Asp Arg Leu Gln Tyr Phe 
            820                 825                 830         


Arg Asp His Ile Asn Asp Ile Ile Lys Ile Gln Ala Phe Ile Arg Ala 
        835                 840                 845             


Asn Lys Ala Arg Asp Asp Tyr Lys Thr Leu Ile Asn Ala Glu Asp Pro 
    850                 855                 860                 


Pro Met Val Val Val Arg Lys Phe Val His Leu Leu Asp Gln Ser Asp 
865                 870                 875                 880 


Gln Asp Phe Gln Glu Glu Leu Asp Leu Met Lys Met Arg Glu Glu Val 
                885                 890                 895     


Ile Thr Leu Ile Arg Ser Asn Gln Gln Leu Glu Asn Asp Leu Asn Leu 
            900                 905                 910         


Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Lys Ile Thr Leu Gln 
        915                 920                 925             


Asp Val Val Ser His Ser Lys Lys Leu Thr Lys Lys Asn Lys Glu Gln 
    930                 935                 940                 


Leu Ser Asp Met Met Met Ile Asn Lys Gln Lys Gly Gly Leu Lys Ala 
945                 950                 955                 960 


Leu Ser Lys Glu Lys Arg Glu Lys Leu Glu Ala Tyr Gln His Leu Phe 
                965                 970                 975     


Tyr Leu Leu Gln Thr Asn Pro Thr Tyr Leu Ala Lys Leu Ile Phe Gln 
            980                 985                 990         


Met Pro Gln Asn Lys Ser Thr Lys  Phe Met Asp Ser Val  Ile Phe Thr 
        995                 1000                 1005             


Leu Tyr  Asn Tyr Ala Ser Asn  Gln Arg Glu Glu Tyr  Leu Leu Leu 
    1010                 1015                 1020             


Arg Leu  Phe Lys Thr Ala Leu  Gln Glu Glu Ile Lys  Ser Lys Val 
    1025                 1030                 1035             


Asp Gln  Ile Gln Glu Ile Val  Thr Gly Asn Pro Thr  Val Ile Lys 
    1040                 1045                 1050             


Met Val  Val Ser Phe Asn Arg  Gly Ala Arg Gly Gln  Asn Ala Leu 
    1055                 1060                 1065             


Arg Gln  Ile Leu Ala Pro Val  Val Lys Glu Ile Met  Asp Asp Lys 
    1070                 1075                 1080             


Ser Leu  Asn Ile Lys Thr Asp  Pro Val Asp Ile Tyr  Lys Ser Trp 
    1085                 1090                 1095             


Val Asn  Gln Met Glu Ser Gln  Thr Gly Glu Ala Ser  Lys Leu Pro 
    1100                 1105                 1110             


Tyr Asp  Val Thr Pro Glu Gln  Ala Leu Ala His Glu  Glu Val Lys 
    1115                 1120                 1125             


Thr Arg  Leu Asp Ser Ser Ile  Arg Asn Met Arg Ala  Val Thr Asp 
    1130                 1135                 1140             


Lys Phe  Leu Ser Ala Ile Val  Ser Ser Val Asp Lys  Ile Pro Tyr 
    1145                 1150                 1155             


Gly Met  Arg Phe Ile Ala Lys  Val Leu Lys Asp Ser  Leu His Glu 
    1160                 1165                 1170             


Lys Phe  Pro Asp Ala Gly Glu  Asp Glu Leu Leu Lys  Ile Ile Gly 
    1175                 1180                 1185             


Asn Leu  Leu Tyr Tyr Arg Tyr  Met Asn Pro Ala Ile  Val Ala Pro 
    1190                 1195                 1200             


Asp Ala  Phe Asp Ile Ile Asp  Leu Ser Ala Gly Gly  Gln Leu Thr 
    1205                 1210                 1215             


Thr Asp  Gln Arg Arg Asn Leu  Gly Ser Ile Ala Lys  Met Leu Gln 
    1220                 1225                 1230             


His Ala  Ala Ser Asn Lys Met  Phe Leu Gly Asp Asn  Ala His Leu 
    1235                 1240                 1245             


Ser Ile  Ile Asn Glu Tyr Leu  Ser Gln Ser Tyr Gln  Lys Phe Arg 
    1250                 1255                 1260             


Arg Phe  Phe Gln Thr Ala Cys  Asp Val Pro Glu Leu  Gln Asp Lys 
    1265                 1270                 1275             


Phe Asn  Val Asp Glu Tyr Ser  Asp Leu Val Thr Leu  Thr Lys Pro 
    1280                 1285                 1290             


Val Ile  Tyr Ile Ser Ile Gly  Glu Ile Ile Asn Thr  His Thr Leu 
    1295                 1300                 1305             


Leu Leu  Asp His Gln Asp Ala  Ile Ala Pro Glu His  Asn Asp Pro 
    1310                 1315                 1320             


Ile His  Glu Leu Leu Asp Asp  Leu Gly Glu Val Pro  Thr Ile Glu 
    1325                 1330                 1335             


Ser Leu  Ile Gly Glu Ser Ser  Gly Asn Leu Asn Asp  Pro Asn Lys 
    1340                 1345                 1350             


Glu Ala  Leu Ala Lys Thr Glu  Val Ser Leu Thr Leu  Thr Asn Lys 
    1355                 1360                 1365             


Phe Asp  Val Pro Gly Asp Glu  Asn Ala Glu Met Asp  Ala Arg Thr 
    1370                 1375                 1380             


Ile Leu  Leu Asn Thr Lys Arg  Leu Ile Val Asp Val  Ile Arg Phe 
    1385                 1390                 1395             


Gln Pro  Gly Glu Thr Leu Thr  Glu Ile Leu Glu Thr  Pro Ala Thr 
    1400                 1405                 1410             


Ser Glu  Gln Glu Ala Glu His  Gln Arg Ala Met Gln  Arg Arg Ala 
    1415                 1420                 1425             


Ile Arg  Asp Ala Lys Thr Pro  Asp Lys Met Lys Lys  Ser Lys Ser 
    1430                 1435                 1440             


Val Lys  Glu Asp Ser Asn Leu  Thr Leu Gln Glu Lys  Lys Glu Lys 
    1445                 1450                 1455             


Ile Gln  Thr Gly Leu Lys Lys  Leu Thr Glu Leu Gly  Thr Val Asp 
    1460                 1465                 1470             


Pro Lys  Asn Lys Tyr Gln Glu  Leu Ile Asn Asp Ile  Ala Arg Asp 
    1475                 1480                 1485             


Ile Arg  Asn Gln Arg Arg Tyr  Arg Gln Arg Arg Lys  Ala Glu Leu 
    1490                 1495                 1500             


Val Lys  Leu Gln Gln Thr Tyr  Ala Ala Leu Asn Ser  Lys Ala Thr 
    1505                 1510                 1515             


Phe Tyr  Gly Glu Gln Val Asp  Tyr Tyr Lys Ser Tyr  Ile Lys Thr 
    1520                 1525                 1530             


Cys Leu  Asp Asn Leu Ala Ser  Lys Gly Lys Val Ser  Lys Lys Pro 
    1535                 1540                 1545             


Arg Glu  Met Lys Gly Lys Lys  Ser Lys Lys Ile Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Thr Ala  Ala Arg Leu His Glu  Lys Gly Val Leu Leu  Glu Ile Glu 
    1565                 1570                 1575             


Asp Leu  Gln Val Asn Gln Phe  Lys Asn Val Ile Phe  Glu Ile Ser 
    1580                 1585                 1590             


Pro Thr  Glu Glu Val Gly Asp  Phe Glu Val Lys Ala  Lys Phe Met 
    1595                 1600                 1605             


Gly Val  Gln Met Glu Thr Phe  Met Leu His Tyr Gln  Asp Leu Leu 
    1610                 1615                 1620             


Gln Leu  Gln Tyr Glu Gly Val  Ala Val Met Lys Leu  Phe Asp Arg 
    1625                 1630                 1635             


Ala Lys  Val Asn Val Asn Leu  Leu Ile Phe Leu Leu  Asn Lys Lys 
    1640                 1645                 1650             


Phe Tyr  Gly Lys 
    1655         


<210>  3338
<211>  4528
<212>  DNA
<213>  Homosapiens

<400>  3338
ggcgggaagt gagccagggc ttggcgcggc ggccgtggtt gcggcgcggg aagtttggat     60

cctggttccg tccgctagga gtctgcgtgc gaggattatg gctgctgttc ctcaaaataa    120

tctacaggag caactagaac gtcactcagc cagaacactt aataataaat taagtctttc    180

aaaaccaaaa ttttcaggtt tcacttttaa aaagaaaaca tcttcagata acaatgtatc    240

tgtaactaat gtgtcagtag caaaaacacc tgtattaaga aataaagatg ttaatgttac    300

cgaagacttt tccttcagtg aacctctacc caacaccaca aatcagcaaa gggtcaagga    360

cttctttaaa aatgctccag caggacagga aacacagaga ggtggatcaa aatcattatt    420

gccagatttc ttgcagactc cgaaggaagt tgtatgcact acccaaaaca caccaactgt    480

aaagaaatcc cgggatactg ctctcaagaa attagaattt agttcttcac cagattcttt    540

aagtaccatc aatgattggg atgatatgga tgactttgat acttctgaga cttcaaaatc    600

atttgttaca ccaccccaaa gtcactttgt aagagtaagc actgctcaga aatcaaaaaa    660

gggtaagaga aactttttta aagcacagct ttatacaaca aacacagtaa agactgattt    720

gcctccaccc tcctctgaaa gcgagcaaat agatttgact gaggaacaga aggatgactc    780

agaatggtta agcagcgatg tgatttgcat cgatgatggc cccattgctg aagtgcatat    840

aaatgaagat gctcaggaaa gtgactctct gaaaactcat ttggaagatg aaagagataa    900

tagcgaaaag aagaagaatt tggaagaagc tgaattacat tcaactgaga aagttccatg    960

tattgaattt gatgatgatg attatgatac ggattttgtt ccaccttctc cagaagaaat   1020

tatttctgct tcttcttcct cttcaaaatg ccttagtacg ttaaaggacc ttgacacctc   1080

tgacagaaaa gaggatgttc ttagcacatc aaaagatctt ttgtcaaaac ctgagaaaat   1140

gagtatgcag gagctgaatc cagaaaccag cacagactgt gacgctagac agataagttt   1200

acagcagcag cttattcatg tgatggagca catctgtaaa ttaattgata ctattcctga   1260

tgataaactg aaacttttgg attgtgggaa cgaactgctt cagcagcgga acataagaag   1320

gaaacttcta acggaagtag attttaataa aagtgatgcc agtcttcttg gctcattgtg   1380

gagatacagg cctgattcac ttgatggccc tatggagggt gattcctgcc ctacagggaa   1440

ttctatgaag gagttaaatt tttcacacct tccctcaaat tctgtttctc ctggggactg   1500

tttactgact accaccctag gaaagacagg attctctgcc accaggaaga atctttttga   1560

aaggccttta ttcaataccc atttacagaa gtcctttgta agtagcaact gggctgaaac   1620

accaagacta ggaaaaaaaa atgaaagctc ttatttccca ggaaatgttc tcacaagcac   1680

tgctgtgaaa gatcagaata aacatactgc ttcaataaat gacttagaaa gagaaaccca   1740

accttcctat gatattgata attttgacat agatgacttt gatgatgatg atgactggga   1800

agacataatg cataatttag cagccagcaa atcttccaca gctgcctatc aacccatcaa   1860

ggaaggtcgg ccaattaaat cagtatcaga aagactttcc tcagccaaga cagactgtct   1920

tccagtgtca tctactgctc aaaatataaa cttctcagag tcaattcaga attatactga   1980

caagtcagca caaaatttag catccagaaa tctgaaacat gagcgtttcc aaagtcttag   2040

ttttcctcat acaaaggaaa tgatgaagat ttttcataaa aaatttggcc tgcataattt   2100

tagaactaat cagctagagg cgatcaatgc tgcactgctt ggtgaagact gttttatcct   2160

gatgccgact ggaggtggta agagtttgtg ttaccagctc cctgcctgtg tttctcctgg   2220

ggtcactgtt gtcatttctc ccttgagatc acttatcgta gatcaagtcc aaaagctgac   2280

ttccttggat attccagcta catatctgac aggtgataag actgactcag aagctacaaa   2340

tatttacctc cagttatcaa aaaaagaccc aatcataaaa cttctatatg tcactccaga   2400

aaagatctgt gcaagtaaca gactcatttc tactctggag aatctctatg agaggaagct   2460

cttggcacgt tttgttattg atgaagcaca ttgtgtcagt cagtggggac atgattttcg   2520

tcaagattac aaaagaatga atatgcttcg ccagaagttt ccttctgttc cggtgatggc   2580

tcttacggcc acagctaatc ccagggtaca gaaggacatc ctgactcagc tgaagattct   2640

cagacctcag gtgtttagca tgagctttaa cagacataat ctgaaatact atgtattacc   2700

gaaaaagcct aaaaaggtgg catttgattg cctagaatgg atcagaaagc accacccata   2760

tgattcaggg ataatttact gcctctccag gcgagaatgt gacaccatgg ctgacacgtt   2820

acagagagat gggctcgctg ctcttgctta ccatgctggc ctcagtgatt ctgccagaga   2880

tgaagtgcag cagaagtgga ttaatcagga tggctgtcag gttatctgtg ctacaattgc   2940

atttggaatg gggattgaca aaccggacgt gcgatttgtg attcatgcat ctctccctaa   3000

atctgtggag ggttactacc aagaatctgg cagagctgga agagatgggg aaatatctca   3060

ctgcctgctt ttctatacct atcatgatgt gaccagactg aaaagactta taatgatgga   3120

aaaagatgga aaccatcata caagagaaac tcacttcaat aatttgtata gcatggtaca   3180

ttactgtgaa aatataacgg aatgcaggag aatacagctt ttggcctact ttggtgaaaa   3240

tggatttaat cctgattttt gtaagaaaca cccagatgtt tcttgtgata attgctgtaa   3300

aacaaaggat tataaaacaa gagatgtgac tgacgatgtg aaaagtattg taagatttgt   3360

tcaagaacat agttcatcac aaggaatgag aaatataaaa catgtaggtc cttctggaag   3420

atttactatg aatatgctgg tcgacatttt cttggggagt aagagtgcaa aaatccagtc   3480

aggtatattt ggaaaaggat ctgcttattc acgacacaat gccgaaagac tttttaaaaa   3540

gctgatactt gacaagattt tggatgaaga cttatatatc aatgccaatg accaggcgat   3600

cgcttatgtg atgctcggaa ataaagccca aactgtacta aatggcaatt taaaggtaga   3660

ctttatggaa acagaaaatt ccagcagtgt gaaaaaacaa aaagcgttag tagcaaaagt   3720

gtctcagagg gaagagatgg ttaaaaaatg tcttggagaa cttacagaag tctgcaaatc   3780

tctggggaaa gtttttggtg tccattactt caatattttt aataccgtca ctctcaagaa   3840

gcttgcagaa tctttatctt ctgatcctga ggttttgctt caaattgatg gtgttactga   3900

agacaaactg gaaaaatatg gtgcggaagt gatttcagta ttacagaaat actctgaatg   3960

gacatcgcca gctgaagaca gttccccagg gataagcctg tccagcagca gaggccccgg   4020

aagaagtgcc gctgaggagc tcgacgagga aatacccgta tcttcccact actttgcaag   4080

taaaaccaga aatgaaagga agaggaaaaa gatgccagcc tcccaaaggt ctaagaggag   4140

aaaaactgct tccagtggtt ccaaggcaaa gggggggtct gccacatgta gaaagatatc   4200

ttccaaaacg aaatcctcca gcatcattgg atccagttca gcctcacata cttctcaagc   4260

gacatcagga gccaatagca aattggggat tatggctcca ccgaagccta taaatagacc   4320

gtttcttaag ccttcatatg cattctcata acaaccgaat ctcaatgtac atagaccctc   4380

tttcttgttt gtcagcatct gaccatctgt gactataaag ctgttattct tgttatacca   4440

tttgaagttt ttactcgtct ctattaatat ttaaataaat gctggggggt gatagttctt   4500

ctttttaaaa taaacatttt cttttgaa                                      4528


<210>  3339
<211>  1417
<212>  PRT
<213>  Homosapiens

<400>  3339

Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr 
65                  70                  75                  80  


Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser 
465                 470                 475                 480 


Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr 
                725                 730                 735     


Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Thr Tyr His Asp Val Thr Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Thr  Arg Glu Thr His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Thr Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Thr Lys  Asp Tyr Lys Thr Arg  Asp Val Thr Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Thr  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Gly  Ser Lys Ser Ala Lys  Ile Gln Ser 
    1115                 1120                 1125             


Gly Ile  Phe Gly Lys Gly Ser  Ala Tyr Ser Arg His  Asn Ala Glu 
    1130                 1135                 1140             


Arg Leu  Phe Lys Lys Leu Ile  Leu Asp Lys Ile Leu  Asp Glu Asp 
    1145                 1150                 1155             


Leu Tyr  Ile Asn Ala Asn Asp  Gln Ala Ile Ala Tyr  Val Met Leu 
    1160                 1165                 1170             


Gly Asn  Lys Ala Gln Thr Val  Leu Asn Gly Asn Leu  Lys Val Asp 
    1175                 1180                 1185             


Phe Met  Glu Thr Glu Asn Ser  Ser Ser Val Lys Lys  Gln Lys Ala 
    1190                 1195                 1200             


Leu Val  Ala Lys Val Ser Gln  Arg Glu Glu Met Val  Lys Lys Cys 
    1205                 1210                 1215             


Leu Gly  Glu Leu Thr Glu Val  Cys Lys Ser Leu Gly  Lys Val Phe 
    1220                 1225                 1230             


Gly Val  His Tyr Phe Asn Ile  Phe Asn Thr Val Thr  Leu Lys Lys 
    1235                 1240                 1245             


Leu Ala  Glu Ser Leu Ser Ser  Asp Pro Glu Val Leu  Leu Gln Ile 
    1250                 1255                 1260             


Asp Gly  Val Thr Glu Asp Lys  Leu Glu Lys Tyr Gly  Ala Glu Val 
    1265                 1270                 1275             


Ile Ser  Val Leu Gln Lys Tyr  Ser Glu Trp Thr Ser  Pro Ala Glu 
    1280                 1285                 1290             


Asp Ser  Ser Pro Gly Ile Ser  Leu Ser Ser Ser Arg  Gly Pro Gly 
    1295                 1300                 1305             


Arg Ser  Ala Ala Glu Glu Leu  Asp Glu Glu Ile Pro  Val Ser Ser 
    1310                 1315                 1320             


His Tyr  Phe Ala Ser Lys Thr  Arg Asn Glu Arg Lys  Arg Lys Lys 
    1325                 1330                 1335             


Met Pro  Ala Ser Gln Arg Ser  Lys Arg Arg Lys Thr  Ala Ser Ser 
    1340                 1345                 1350             


Gly Ser  Lys Ala Lys Gly Gly  Ser Ala Thr Cys Arg  Lys Ile Ser 
    1355                 1360                 1365             


Ser Lys  Thr Lys Ser Ser Ser  Ile Ile Gly Ser Ser  Ser Ala Ser 
    1370                 1375                 1380             


His Thr  Ser Gln Ala Thr Ser  Gly Ala Asn Ser Lys  Leu Gly Ile 
    1385                 1390                 1395             


Met Ala  Pro Pro Lys Pro Ile  Asn Arg Pro Phe Leu  Lys Pro Ser 
    1400                 1405                 1410             


Tyr Ala  Phe Ser 
    1415         


<210>  3340
<211>  4180
<212>  DNA
<213>  Homosapiens

<400>  3340
gcggggaagc agcagcggcc aggatgaatc ccaggtgctc tggagctgga tggtgaaggt     60

cggcactctt caccctcccg agccctgccc gtctcggccc catgccccca ccagtcagcc    120

ccgggccaca ggcagtgagc aggcacctgg gagccgaggc cctgtgacca ggccaaggag    180

acgggcgctc cagggtccca gccacctgtc ccccccatgg agctgaggcc ctggttgcta    240

tgggtggtag cagcaacagg aaccttggtc ctgctagcag ctgatgctca gggccagaag    300

gtcttcacca acacgtgggc tgtgcgcatc cctggaggcc cagcggtggc caacagtgtg    360

gcacggaagc atgggttcct caacctgggc cagatcttcg gggactatta ccacttctgg    420

catcgaggag tgacgaagcg gtccctgtcg cctcaccgcc cgcggcacag ccggctgcag    480

agggagcctc aagtacagtg gctggaacag caggtggcaa agcgacggac taaacgggac    540

gtgtaccagg agcccacaga ccccaagttt cctcagcagt ggtacctgtc tggtgtcact    600

cagcgggacc tgaatgtgaa ggcggcctgg gcgcagggct acacagggca cggcattgtg    660

gtctccattc tggacgatgg catcgagaag aaccacccgg acttggcagg caattatgat    720

cctggggcca gttttgatgt caatgaccag gaccctgacc cccagcctcg gtacacacag    780

atgaatgaca acaggcacgg cacacggtgt gcgggggaag tggctgcggt ggccaacaac    840

ggtgtctgtg gtgtaggtgt ggcctacaac gcccgcattg gaggggtgcg catgctggat    900

ggcgaggtga cagatgcagt ggaggcacgc tcgctgggcc tgaaccccaa ccacatccac    960

atctacagtg ccagctgggg ccccgaggat gacggcaaga cagtggatgg gccagcccgc   1020

ctcgccgagg aggccttctt ccgtggggtt agccagggcc gaggggggct gggctccatc   1080

tttgtctggg cctcggggaa cgggggccgg gaacatgaca gctgcaactg cgacggctac   1140

accaacagta tctacacgct gtccatcagc agcgccacgc agtttggcaa cgtgccgtgg   1200

tacagcgagg cctgctcgtc cacactggcc acgacctaca gcagtggcaa ccagaatgag   1260

aagcagatcg tgacgactga cttgcggcag aagtgcacgg agtctcacac gggcacctca   1320

gcctctgccc ccttagcagc cggcatcatt gctctcaccc tggaggccaa taagaacctc   1380

acatggcggg acatgcaaca cctggtggta cagacctcga agccagccca cctcaatgcc   1440

aacgactggg ccaccaatgg tgtgggccgg aaagtgagcc actcatatgg ctacgggctt   1500

ttggacgcag gcgccatggt ggccctggcc cagaattgga ccacagtggc cccccagcgg   1560

aagtgcatca tcgacatcct caccgagccc aaagacatcg ggaaacggct cgaggtgcgg   1620

aagaccgtga ccgcgtgcct gggcgagccc aaccacatca ctcggctgga gcacgctcag   1680

gcgcggctca ccctgtccta taatcgccgt ggcgacctgg ccatccacct ggtcagcccc   1740

atgggcaccc gctccaccct gctggcagcc aggccacatg actactccgc agatgggttt   1800

aatgactggg ccttcatgac aactcattcc tgggatgagg atccctctgg cgagtgggtc   1860

ctagagattg aaaacaccag cgaagccaac aactatggga cgctgaccaa gttcaccctc   1920

gtactctatg gcaccgcccc tgaggggctg cccgtacctc cagaaagcag tggctgcaag   1980

accctcacgt ccagtcaggc ctgtgtggtg tgcgaggaag gcttctccct gcaccagaag   2040

agctgtgtcc agcactgccc tccagggttc gccccccaag tcctcgatac gcactatagc   2100

accgagaatg acgtggagac catccgggcc agcgtctgcg ccccctgcca cgcctcatgt   2160

gccacatgcc aggggccggc cctgacagac tgcctcagct gccccagcca cgcctccttg   2220

gaccctgtgg agcagacttg ctcccggcaa agccagagca gccgagagtc cccgccacag   2280

cagcagccac ctcggctgcc cccggaggtg gaggcggggc aacggctgcg ggcagggctg   2340

ctgccctcac acctgcctga ggtggtggcc ggcctcagct gcgccttcat cgtgctggtc   2400

ttcgtcactg tcttcctggt cctgcagctg cgctctggct ttagttttcg gggggtgaag   2460

gtgtacacca tggaccgtgg cctcatctcc tacaaggggc tgccccctga agcctggcag   2520

gaggagtgcc cgtctgactc agaagaggac gagggccggg gcgagaggac cgcctttatc   2580

aaagaccaga gcgccctctg atgagcccac tgcccacccc ctcaagccaa tcccctcctt   2640

gggcactttt taattcacca aagtattttt ttatcttggg actgggtttg gaccccagct   2700

gggaggcaag aggggtggag actgcttccc atcctaccct cgggcccacc tggccacctg   2760

aggtgggccc aggaccagct ggggcgtggg gagggccgta ccccaccctc agcacccctt   2820

ccatgtggag aaaggagtga aacctttagg gcagcttgcc ccggccccgg ccccagccag   2880

agttcctgcg gagtgaagag gggcagccct tgcttgttgg gattcctgac ccaggccgca   2940

gctcttgccc ttccctgtcc ctctaaagca ataatggtcc catccaggca gtcgggggct   3000

ggcctaggag atatctgagg gaggaggcca cctctccaag ggcttctgca ccctccaccc   3060

tgtcccccag ctctggtgag tcttggcggc agcagccatc ataggaaggg accaaggcaa   3120

ggcaggtgcc tccaggtgtg cacgtggcat gtggcctgtg gcctgtgtcc catgacccac   3180

ccctgtgctc cgtgcctcca ccaccactgg ccaccaggct ggcgcagcca aggccgaagc   3240

tctggctgaa ccctgtgctg gtgtcctgac caccctcccc tctcttgcac ccgcctctcc   3300

cgtcagggcc caagtccctg ttttctgagc ccgggctgcc tgggctgttg gcactcacag   3360

acctggagcc cctgggtggg tggtggggag gggcgctggc ccagccggcc tctctggcct   3420

cccacccgat gctgctttcc cctgtgggga tctcaggggc tgtttgagga tatattttca   3480

ctttgtgatt atttcacttt agatgctgat gatttgtttt tgtattttta atgggggtag   3540

cagctggact acccacgttc tcacacccac cgtccgccct gctcctccct ggctgccctg   3600

gccctgaggt gtgggggctg cagcatgttg ctgaggagtg aggaatagtt gagccccaag   3660

tcctgaagag gcgggccagc caggcgggct caaggaaagg gggtcccagt gggaggggca   3720

ggctgacatc tgtgtttcaa gtggggctcg ccatgccggg ggttcatagg tcactggctc   3780

tccaagtgcc agaggtgggc aggtggtggc actgagcccc cccaacactg tgccctggtg   3840

gagaaagcac tgacctgtca tgcccccctc aaacctcctc ttctgacgtg ccttttgcac   3900

ccctcccatt aggacaatca gtcccctccc atctgggagt ccccttttct tttctaccct   3960

agccattcct ggtacccagc catctgccca ggggtgcccc ctcctctccc atccccctgc   4020

cctcgtggcc agcccggctg gttttgtaag atgctgggtt ggtgcacagt gatttttttc   4080

ttgtaattta aacaggccca gcattgctgg ttctatttaa tggacatgag ataatgttag   4140

aggttttaaa gtgattaaac gtgcagacta tgcaaaccag                         4180


<210>  3341
<211>  794
<212>  PRT
<213>  Homosapiens

<400>  3341

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  3342
<211>  2762
<212>  DNA
<213>  Homosapiens

<400>  3342
actggccggg gtccgcaccg ggcctgagtc ggtccgaggc cgtcccagga gcagctgccc     60

gtgcggaaca gcactatggg cttctcttcc gagctgtgca gcccccaggg ccacggggtc    120

ctgcagcaaa tgcaggaggc cgagcttcgt ctactggagg gcatgagaaa gtggatggcc    180

cagcgggtca agagtgacag ggagtatgca ggactgcttc accacatgtc cctgcaggac    240

agtgggggcc agagccgggc catcagccct gacagcccca tcagtcagtc ctgggctgag    300

atcaccagcc aaactgaggg cctgagccgc ttgctgcggc agcacgcaga ggatctgaac    360

tcagggcccc tgagcaagct gagcctgctc atccgggaac ggcagcagct tcgcaagacc    420

tacagcgagc agtggcagca gctgcagcag gagctcacca agacccacag ccaggacatt    480

gagaagctga agagccagta ccgagctctg gcacgggaca gtgcccaagc caagcgcaag    540

taccaggagg ccagcaaaga caaggaccgt gacaaggcca aggacaagta tgtgcgcagc    600

ctgtggaagc tctttgctca ccacaaccgc tatgtgctgg gcgtgcgggc tgcgcagcta    660

caccaccagc accaccacca gctcctgctg cccggcctgc tgcggtcact gcaggacctg    720

cacgaggaga tggcttgcat cctgaaggag atcctgcagg aatacctgga gattagcagc    780

ctggtgcagg atgaggtggt ggccattcac cgggagatgg ctgcagctgc tgcccgcatc    840

cagcctgagg ctgagtacca aggcttcctg cgacagtatg ggtccgcacc tgacgtccca    900

ccctgtgtca cgttcgatga gtcactgctt gaggagggtg aaccgctgga gcctggggag    960

ctccagctga acgagctgac tgtggagagc gtgcagcaca cgctgacctc agtgacagat   1020

gagctggctg tggccaccga gatggtgttc aggcggcagg agatggttac gcagctgcaa   1080

caggagctcc ggaatgaaga ggagaacacc cacccccggg agcgggtgca gctgctgggc   1140

aagaggcaag tgctgcaaga agcactgcag gggctgcagg tagcgctgtg cagccaggcc   1200

aagctgcagg cccagcagga gttgctgcag accaagctgg agcacctggg ccccggcgag   1260

cccccgcctg tgctgctcct gcaggatgac cgccactcca cgtcgtcctc ggagcaggag   1320

cgagaggggg gaaggacacc cacgctggag atccttaaga gccacatctc aggaatcttc   1380

cgccccaagt tctcgctccc tccaccgctg cagctcattc cggaggtgca gaagcccctg   1440

catgagcagc tgtggtacca cggggccatc ccgagggcag aggtggctga gctgctggtg   1500

cactctgggg acttcctggt gcgggagagc cagggcaagc aggagtacgt gctgtcggtg   1560

ctgtgggatg gtctgccccg gcacttcatc atccagtcct tggataacct gtaccgactg   1620

gaaggggaag gctttcctag cattcctttg ctcatcgacc acctactgag cacccagcag   1680

cccctcacca agaagagtgg tgttgtcctg cacagggctg tgcccaagga caagtgggtg   1740

ctgaaccatg aggacctggt gttgggtgag cagattggac gggggaactt tggcgaagtg   1800

ttcagcggac gcctgcgagc cgacaacacc ctggtggcgg tgaagtcttg tcgagagacg   1860

ctcccacctg acctcaaggc caagtttcta caggaagcga ggatcctgaa gcagtacagc   1920

caccccaaca tcgtgcgtct cattggtgtc tgcacccaga agcagcccat ctacatcgtc   1980

atggagcttg tgcagggggg cgacttcctg accttcctcc gcacggaggg ggcccgcctg   2040

cgggtgaaga ctctgctgca gatggtgggg gatgcagctg ctggcatgga gtacctggag   2100

agcaagtgct gcatccaccg ggacctggct gctcggaact gcctggtgac agagaagaat   2160

gtcctgaaga tcagtgactt tgggatgtcc cgagaggaag ccgatggggt ctatgcagcc   2220

tcagggggcc tcagacaagt ccccgtgaag tggaccgcac ctgaggccct taactacggc   2280

cgctactcct ccgaaagcga cgtgtggagc tttggcatct tgctctggga gaccttcagc   2340

ctgggggcct ccccctatcc caacctcagc aatcagcaga cacgggagtt tgtggagaag   2400

gggggccgtc tgccctgccc agagctgtgt cctgatgccg tgttcaggct catggagcag   2460

tgctgggcct atgagcctgg gcagcggccc agcttcagca ccatctacca ggagctgcag   2520

agcatccgaa agcggcatcg gtgaggctgg gacccccttc tcaagctggt ggcctctgca   2580

ggcctaggtg cagctcctca gcggctccag ctcatatgct gacagctctt cacagtcctg   2640

gactcctgcc accagcatcc acactgccgg caggatgcag cgccgtgtcc tctctgtgtc   2700

cctgctgctg ccagggcttc ctcttccggg cagaaacaat aaaaccactt gtgcccactg   2760

aa                                                                  2762


<210>  3343
<211>  822
<212>  PRT
<213>  Homosapiens

<400>  3343

Met Gly Phe Ser Ser Glu Leu Cys Ser Pro Gln Gly His Gly Val Leu 
1               5                   10                  15      


Gln Gln Met Gln Glu Ala Glu Leu Arg Leu Leu Glu Gly Met Arg Lys 
            20                  25                  30          


Trp Met Ala Gln Arg Val Lys Ser Asp Arg Glu Tyr Ala Gly Leu Leu 
        35                  40                  45              


His His Met Ser Leu Gln Asp Ser Gly Gly Gln Ser Arg Ala Ile Ser 
    50                  55                  60                  


Pro Asp Ser Pro Ile Ser Gln Ser Trp Ala Glu Ile Thr Ser Gln Thr 
65                  70                  75                  80  


Glu Gly Leu Ser Arg Leu Leu Arg Gln His Ala Glu Asp Leu Asn Ser 
                85                  90                  95      


Gly Pro Leu Ser Lys Leu Ser Leu Leu Ile Arg Glu Arg Gln Gln Leu 
            100                 105                 110         


Arg Lys Thr Tyr Ser Glu Gln Trp Gln Gln Leu Gln Gln Glu Leu Thr 
        115                 120                 125             


Lys Thr His Ser Gln Asp Ile Glu Lys Leu Lys Ser Gln Tyr Arg Ala 
    130                 135                 140                 


Leu Ala Arg Asp Ser Ala Gln Ala Lys Arg Lys Tyr Gln Glu Ala Ser 
145                 150                 155                 160 


Lys Asp Lys Asp Arg Asp Lys Ala Lys Asp Lys Tyr Val Arg Ser Leu 
                165                 170                 175     


Trp Lys Leu Phe Ala His His Asn Arg Tyr Val Leu Gly Val Arg Ala 
            180                 185                 190         


Ala Gln Leu His His Gln His His His Gln Leu Leu Leu Pro Gly Leu 
        195                 200                 205             


Leu Arg Ser Leu Gln Asp Leu His Glu Glu Met Ala Cys Ile Leu Lys 
    210                 215                 220                 


Glu Ile Leu Gln Glu Tyr Leu Glu Ile Ser Ser Leu Val Gln Asp Glu 
225                 230                 235                 240 


Val Val Ala Ile His Arg Glu Met Ala Ala Ala Ala Ala Arg Ile Gln 
                245                 250                 255     


Pro Glu Ala Glu Tyr Gln Gly Phe Leu Arg Gln Tyr Gly Ser Ala Pro 
            260                 265                 270         


Asp Val Pro Pro Cys Val Thr Phe Asp Glu Ser Leu Leu Glu Glu Gly 
        275                 280                 285             


Glu Pro Leu Glu Pro Gly Glu Leu Gln Leu Asn Glu Leu Thr Val Glu 
    290                 295                 300                 


Ser Val Gln His Thr Leu Thr Ser Val Thr Asp Glu Leu Ala Val Ala 
305                 310                 315                 320 


Thr Glu Met Val Phe Arg Arg Gln Glu Met Val Thr Gln Leu Gln Gln 
                325                 330                 335     


Glu Leu Arg Asn Glu Glu Glu Asn Thr His Pro Arg Glu Arg Val Gln 
            340                 345                 350         


Leu Leu Gly Lys Arg Gln Val Leu Gln Glu Ala Leu Gln Gly Leu Gln 
        355                 360                 365             


Val Ala Leu Cys Ser Gln Ala Lys Leu Gln Ala Gln Gln Glu Leu Leu 
    370                 375                 380                 


Gln Thr Lys Leu Glu His Leu Gly Pro Gly Glu Pro Pro Pro Val Leu 
385                 390                 395                 400 


Leu Leu Gln Asp Asp Arg His Ser Thr Ser Ser Ser Glu Gln Glu Arg 
                405                 410                 415     


Glu Gly Gly Arg Thr Pro Thr Leu Glu Ile Leu Lys Ser His Ile Ser 
            420                 425                 430         


Gly Ile Phe Arg Pro Lys Phe Ser Leu Pro Pro Pro Leu Gln Leu Ile 
        435                 440                 445             


Pro Glu Val Gln Lys Pro Leu His Glu Gln Leu Trp Tyr His Gly Ala 
    450                 455                 460                 


Ile Pro Arg Ala Glu Val Ala Glu Leu Leu Val His Ser Gly Asp Phe 
465                 470                 475                 480 


Leu Val Arg Glu Ser Gln Gly Lys Gln Glu Tyr Val Leu Ser Val Leu 
                485                 490                 495     


Trp Asp Gly Leu Pro Arg His Phe Ile Ile Gln Ser Leu Asp Asn Leu 
            500                 505                 510         


Tyr Arg Leu Glu Gly Glu Gly Phe Pro Ser Ile Pro Leu Leu Ile Asp 
        515                 520                 525             


His Leu Leu Ser Thr Gln Gln Pro Leu Thr Lys Lys Ser Gly Val Val 
    530                 535                 540                 


Leu His Arg Ala Val Pro Lys Asp Lys Trp Val Leu Asn His Glu Asp 
545                 550                 555                 560 


Leu Val Leu Gly Glu Gln Ile Gly Arg Gly Asn Phe Gly Glu Val Phe 
                565                 570                 575     


Ser Gly Arg Leu Arg Ala Asp Asn Thr Leu Val Ala Val Lys Ser Cys 
            580                 585                 590         


Arg Glu Thr Leu Pro Pro Asp Leu Lys Ala Lys Phe Leu Gln Glu Ala 
        595                 600                 605             


Arg Ile Leu Lys Gln Tyr Ser His Pro Asn Ile Val Arg Leu Ile Gly 
    610                 615                 620                 


Val Cys Thr Gln Lys Gln Pro Ile Tyr Ile Val Met Glu Leu Val Gln 
625                 630                 635                 640 


Gly Gly Asp Phe Leu Thr Phe Leu Arg Thr Glu Gly Ala Arg Leu Arg 
                645                 650                 655     


Val Lys Thr Leu Leu Gln Met Val Gly Asp Ala Ala Ala Gly Met Glu 
            660                 665                 670         


Tyr Leu Glu Ser Lys Cys Cys Ile His Arg Asp Leu Ala Ala Arg Asn 
        675                 680                 685             


Cys Leu Val Thr Glu Lys Asn Val Leu Lys Ile Ser Asp Phe Gly Met 
    690                 695                 700                 


Ser Arg Glu Glu Ala Asp Gly Val Tyr Ala Ala Ser Gly Gly Leu Arg 
705                 710                 715                 720 


Gln Val Pro Val Lys Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg 
                725                 730                 735     


Tyr Ser Ser Glu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu 
            740                 745                 750         


Thr Phe Ser Leu Gly Ala Ser Pro Tyr Pro Asn Leu Ser Asn Gln Gln 
        755                 760                 765             


Thr Arg Glu Phe Val Glu Lys Gly Gly Arg Leu Pro Cys Pro Glu Leu 
    770                 775                 780                 


Cys Pro Asp Ala Val Phe Arg Leu Met Glu Gln Cys Trp Ala Tyr Glu 
785                 790                 795                 800 


Pro Gly Gln Arg Pro Ser Phe Ser Thr Ile Tyr Gln Glu Leu Gln Ser 
                805                 810                 815     


Ile Arg Lys Arg His Arg 
            820         


<210>  3344
<211>  6279
<212>  DNA
<213>  Homosapiens

<400>  3344
gtgtgtgtgg aggccagtat gaagctgaaa aagcaggtga cagtgtgtgg ggctgccatc     60

ttctgtgtgg cagtcttctc gctctacctc atgctggacc gagtgcaaca cgatcccacc    120

cgacaccaga atggtgggaa cttcccccgg agccaaattt ctgtgctgca gaaccgcatt    180

gagcagctgg agcagctttt ggaggagaac catgagatta tcagccatat caaggactcc    240

gtgctggagc tgacagccaa cgcagagggc ccgcccgcca tgctgcccta ctacacggtc    300

aatggctcct gggtggtgcc accggagccc cggcccagct tcttctccat ctccccgcag    360

gactgccagt ttgctttggg gggccggggt cagaagccag agctgcagat gctcactgtg    420

tcggaggagc tgccgtttga caacgtggat ggtggtgtgt ggaggcaagg cttcgacatc    480

tcctacgacc cgcacgactg ggatgctgaa gacctgcagg tgtttgtggt gccccactct    540

cacaatgacc caggctggat caagaccttt gacaagtact acacagagca gacccaacac    600

atcctcaata gcatggtgtc taagctgcag gaggaccccc ggcggcgctt cctctgggca    660

gaggtctcct tcttcgccaa gtggtgggac aacatcaatg tccaaaagag agcggcagtc    720

cgaaggctgg tgggaaacgg gcagctggag attgcgacag gaggctgggt gatgccagat    780

gaggccaatt cccactactt tgcattgatt gaccagctca tcgaaggaca ccagtggctg    840

gagagaaatc ttggtgcaac cccccgctct ggctgggcag tggacccctt tggatacagc    900

tccaccatgc cttacctgct gcgccgtgcc aacctcacca gcatgctgat tcagagagtg    960

cactatgcca tcaagaagca ctttgctgcc acccacagcc tagagttcat gtggaggcag   1020

acatgggact cggactccag cacagacatc ttctgtcaca tgatgccctt ctacagctat   1080

gacgtccccc atacctgtgg cccagatccc aagatctgct gccaatttga tttcaaacgc   1140

ctgcctggtg ggcgcatcaa ctgcccttgg aaggtgccac cccgggccat cacagaggcc   1200

aacgtggcag agagggcagc cctgcttctg gaccaatacc ggaagaagtc ccagctgttc   1260

cgaagcaacg tcctcctggt gcctcttgga gatgacttcc gatatgacaa gccccaggag   1320

tgggatgccc agttcttcaa ctaccaacgg ctctttgact tcttcaacag caggcctaac   1380

ctccatgtgc aggcccagtt tggcactctt tctgactatt ttgatgccct gtacaagagg   1440

acaggggtgg agccaggggc ccggcctcca gggtttcctg tgctgagcgg ggatttcttc   1500

tcctatgcgg accgggagga tcattactgg acaggctatt acacttcccg gcccttctac   1560

aagagcttag accgagtcct ggaagcccac ctgcgggggg cagaggttct gtacagcctg   1620

gctgcagctc acgctcgccg ctctggtctg gctggccggt acccactgtc tgatttcacc   1680

ctcctgacgg aagctcggcg cacattgggg ctcttccagc atcacgatgc catcactggc   1740

acggccaagg aggctgtggt ggtggactat ggggtcaggc ttctgcgctc ccttgtcaac   1800

ctgaagcagg tcatcattca tgcagcccac tatctggtgc tgggggacaa ggagacctac   1860

cactttgacc ctgaggcgcc cttcctccaa gtggatgaca ctcgcttaag tcacgacgcc   1920

ctcccagagc gcacggtgat ccagctggat tcctcgccca ggtttgtggt cctattcaac   1980

ccactggaac aggagcgatt cagcatggtg tccctgctgg tcaactctcc ccgcgtgcgt   2040

gtcctttcgg aggagggtca gcccctggcc gtgcagatca gcgcacactg gagctctgcc   2100

accgaggcgg tccctgacgt ctaccaggtg tctgtgcctg tccgcctgcc agccctgggc   2160

ctgggcgtgc tgcagctaca gctgggcctg gatgggcacc gcacgctgcc ctcctctgtg   2220

cgcatctacc tgcacggccg gcagctgtcc gtcagcaggc acgaagcgtt tcctctccgt   2280

gtcattgact ctggcaccag cgacttcgcc ctcagcaacc gctacatgca ggtctggttc   2340

tcaggcctta ctgggctcct caagagcatc cgaagggtgg atgaggagca cgagcagcag   2400

gtggacatgc aggtccttgt ctatggcacc cgtacgtcca aagacaagag tggagcctac   2460

ctcttcctgc ccgatggcga ggccaagccc tacgtcccca aggagccccc cgtgctgcgt   2520

gtcactgaag gccctttctt ctcagaggtg gttgcgtact atgagcacat tcaccaggcg   2580

gtccggcttt acaatctgcc aggggtggag gggctgtctc tggacatatc atccctggtg   2640

gacatccggg actacgtcaa caaggagctg gccctgcaca tccatacaga catcgacagc   2700

cagggtatct tcttcacaga cctcaatggc tttcaggtgc agccccgacg gtatctgaag   2760

aagctccccc tccaggccaa cttctacccc atgccagtca tggcctatat ccaggacgca   2820

cagaagcgcc tcacgctgca cactgcccag gccctgggtg tctctagcct caaagatggc   2880

cagctggagg tgatcttgga ccggcggctg atgcaggatg acaaccgggg cctaggccaa   2940

gggctcaagg acaacaagag aacctgcaac cgtttccgcc tcctgctaga gcggcgaacc   3000

gtgggcagtg aggtccaaga tagccactct accagctacc catccctcct cagccacctg   3060

acctccatgt acctgaacgc cccggcgctc gctctgcctg tagccaggat gcagctccca   3120

ggccctggtc tgcgctcatt tcatcctctg gcttcctcac tgccctgtga cttccacctg   3180

ctcaacctac gtacgctcca ggctgaggag gacaccctac cctcggcgga gaccgcactc   3240

atcttacacc gcaagggttt tgactgcggc ctggaggcca agaacttggg cttcaactgc   3300

accacaagcc aaggcaaggt agccctgggc agccttttcc atggcctgga tgtggtattc   3360

cttcagccaa cctccttgac gttactgtac cctctggcct ccccgtccaa cagcactgac   3420

gtctatttgg agcccatgga gattgctacc tttcgcctcc gcttgggtta gggcttcttg   3480

tggcctgaag agaaagttca ttcacagaga ctgcctctta acatgaagat cattggacaa   3540

gccacacggg tatcccatcc cgatctgcct cccagaactg tgacacactg ggctctgccc   3600

tcattttctg tttattgctg ctgctgtgtt ttcggcgcaa cccacaaacc cagtgatggg   3660

taaatagggc agacgccagt gagatcaggg agagaaggcc cttggtcaga gtgggcagtg   3720

ccaggctctg ctttgggttg tgagtggaca cccaactggg cacaggctca ggcacccatc   3780

ctttttccaa acagggatat agaagtggtg gaagcagaca gaagaggtaa gggaggctaa   3840

gtgggtaaca gcccagcatc agggtcactg tggcaacagc aggctctagg ggaatcctgt   3900

ggttatgtag agactccatg tcctggtgtg atgagcagga tcagagtgac tctgggagga   3960

caggggtggg gacccagagt tagcagtggg gatggagcag tagaaggaat cactgtttct   4020

cctaggagtc tgaaggcctc gctgctttct gtgatggctt tgcagtaagt gccgcctggc   4080

ctgcatgcat tggctaacag gctgcagaat ggcaggaagg actcgctaga gattgtcatg   4140

gccagagatc ataggtcact tcaggtagca agacccctgg caaactgggc acttggccta   4200

tgtactgatt tgtgggatgg tggcaggggt gtggggtcct tcaccctgcc tgaattctct   4260

ttggcttctg tgctctgtat gctgctgtcc ccaagggctc tttcttatta tggcagggag   4320

tggggattgg tcctactttc tttctctgga aaggaaagcc tccaagactc catgtgcttg   4380

ggcagcttga gaaggcgttc agcaccacgc ctagcaggca gaccttgaag cctcaccttt   4440

agtctatctg cagaggtatt cagttcctgg cacaggggac taggggcatg tagagtatat   4500

gaggaggcag tatggctgtg caggagcctt catttcagct tcaattaata gggaagaatt   4560

tatgatagct ctatagatgc tgaaaaggta tttcgtaaga tttaaaatcc atcccttatt   4620

aaaactctta gtaaattaag tctggaaaga aacaccctaa tctagataaa ggtctgtttc   4680

agaaaccaac agtgatggca ttctaaagag tcagacgcca caggcattcc cattaaagtc   4740

agaaactagc caagggcaag ctattattca gcagtgtccc ggcactacta acccctgcaa   4800

caagccagat gaggaacata aggaagaatt ataattgtca ttatttgtag acaataaaac   4860

tgcctacctg taaaacctaa gaatcaactg aagacctgtt aagagtattc tgtaagtcaa   4920

cccaatgata cacatcatgt tcctgtccac atactggttt tccccaaatc agctgataaa   4980

ttcagtgtaa ttccaatgag attgaaactt tggaattgac agttctaaag tgcatttggg   5040

agagtgaatg tgtgagaaca ctaagaccac tctgaacgat gataatgagt tggggggtgg   5100

actgctcggg ggtgatcctg ccagattccc agaggattct cacgccacca ttacctcact   5160

cagtgtgacc tggagggggt cagacagacg ggagagtcca gaaacagacc cagggctaca   5220

ggaatttagt atatggtaag agggatgttt taagtgggga aaaaggtgga ttatttaata   5280

aacagcactt ttagacaact agctatcaaa gctagatctc agctgggtgc gatggctcac   5340

gcctgtaatc ccggcacttt gggaggccaa ggtgggtgga tcacttgagg tcaggagttc   5400

gagaccagcc tggccaagat ggcgaaaccc tgtgtctact aaaaatacaa aaactagcca   5460

ggaatggtgg cgcgcgcctg taatcccagt tacttaggag gctgaggcag gagaatcaca   5520

tcaacctggg aggcggaggt tgcagtgagc ttagatcatg ccaccatgcc actgcactcc   5580

agcctgggtg acacagccaa aaaaaaaacc actaagttag atctctacct cacagtgtcc   5640

atacaaatta gttccagagg gaagatatac cacaaaatta ctcaaaaatt tttatacctc   5700

tggtgtggga cggtcttttc taaactttaa catgagactt aaaagatata ataagggaaa   5760

agataagcag atttcgcaac caaaaaatat cgaaagtctc tgtgtgatgg aaaacatcaa   5820

ggttaaaaca caaatgacag atatggaaga aaatatttgc agcacataaa aaaatcaacg   5880

agtacaatta ctttaggaga aaagcttgct tcagggtcct tagagaaagt cactggggcc   5940

tgccaagctg ccacctaaag acaagagtga gagggctgag ttcttccagg tcatcagagt   6000

tgttgctgcc cgtattaggc cacacagtgg aaccccattt atatcatagc agaagaaata   6060

ggattatcaa tgtgaactgc ttagcatggt gcctggtata tacgagagct ccacaaatgt   6120

gagctataat cctactagta aaggatgcta agcagttcca ctgtggcagg tgtcatttgc   6180

tagtagaatt tgtaatcaaa caataggagg ggaatctgtg aacgcctaga aaatgagcag   6240

aataaaggat attatctttg gaagtcttaa aaaaaaaaa                          6279


<210>  3345
<211>  1150
<212>  PRT
<213>  Homosapiens

<400>  3345

Met Lys Leu Lys Lys Gln Val Thr Val Cys Gly Ala Ala Ile Phe Cys 
1               5                   10                  15      


Val Ala Val Phe Ser Leu Tyr Leu Met Leu Asp Arg Val Gln His Asp 
            20                  25                  30          


Pro Thr Arg His Gln Asn Gly Gly Asn Phe Pro Arg Ser Gln Ile Ser 
        35                  40                  45              


Val Leu Gln Asn Arg Ile Glu Gln Leu Glu Gln Leu Leu Glu Glu Asn 
    50                  55                  60                  


His Glu Ile Ile Ser His Ile Lys Asp Ser Val Leu Glu Leu Thr Ala 
65                  70                  75                  80  


Asn Ala Glu Gly Pro Pro Ala Met Leu Pro Tyr Tyr Thr Val Asn Gly 
                85                  90                  95      


Ser Trp Val Val Pro Pro Glu Pro Arg Pro Ser Phe Phe Ser Ile Ser 
            100                 105                 110         


Pro Gln Asp Cys Gln Phe Ala Leu Gly Gly Arg Gly Gln Lys Pro Glu 
        115                 120                 125             


Leu Gln Met Leu Thr Val Ser Glu Glu Leu Pro Phe Asp Asn Val Asp 
    130                 135                 140                 


Gly Gly Val Trp Arg Gln Gly Phe Asp Ile Ser Tyr Asp Pro His Asp 
145                 150                 155                 160 


Trp Asp Ala Glu Asp Leu Gln Val Phe Val Val Pro His Ser His Asn 
                165                 170                 175     


Asp Pro Gly Trp Ile Lys Thr Phe Asp Lys Tyr Tyr Thr Glu Gln Thr 
            180                 185                 190         


Gln His Ile Leu Asn Ser Met Val Ser Lys Leu Gln Glu Asp Pro Arg 
        195                 200                 205             


Arg Arg Phe Leu Trp Ala Glu Val Ser Phe Phe Ala Lys Trp Trp Asp 
    210                 215                 220                 


Asn Ile Asn Val Gln Lys Arg Ala Ala Val Arg Arg Leu Val Gly Asn 
225                 230                 235                 240 


Gly Gln Leu Glu Ile Ala Thr Gly Gly Trp Val Met Pro Asp Glu Ala 
                245                 250                 255     


Asn Ser His Tyr Phe Ala Leu Ile Asp Gln Leu Ile Glu Gly His Gln 
            260                 265                 270         


Trp Leu Glu Arg Asn Leu Gly Ala Thr Pro Arg Ser Gly Trp Ala Val 
        275                 280                 285             


Asp Pro Phe Gly Tyr Ser Ser Thr Met Pro Tyr Leu Leu Arg Arg Ala 
    290                 295                 300                 


Asn Leu Thr Ser Met Leu Ile Gln Arg Val His Tyr Ala Ile Lys Lys 
305                 310                 315                 320 


His Phe Ala Ala Thr His Ser Leu Glu Phe Met Trp Arg Gln Thr Trp 
                325                 330                 335     


Asp Ser Asp Ser Ser Thr Asp Ile Phe Cys His Met Met Pro Phe Tyr 
            340                 345                 350         


Ser Tyr Asp Val Pro His Thr Cys Gly Pro Asp Pro Lys Ile Cys Cys 
        355                 360                 365             


Gln Phe Asp Phe Lys Arg Leu Pro Gly Gly Arg Ile Asn Cys Pro Trp 
    370                 375                 380                 


Lys Val Pro Pro Arg Ala Ile Thr Glu Ala Asn Val Ala Glu Arg Ala 
385                 390                 395                 400 


Ala Leu Leu Leu Asp Gln Tyr Arg Lys Lys Ser Gln Leu Phe Arg Ser 
                405                 410                 415     


Asn Val Leu Leu Val Pro Leu Gly Asp Asp Phe Arg Tyr Asp Lys Pro 
            420                 425                 430         


Gln Glu Trp Asp Ala Gln Phe Phe Asn Tyr Gln Arg Leu Phe Asp Phe 
        435                 440                 445             


Phe Asn Ser Arg Pro Asn Leu His Val Gln Ala Gln Phe Gly Thr Leu 
    450                 455                 460                 


Ser Asp Tyr Phe Asp Ala Leu Tyr Lys Arg Thr Gly Val Glu Pro Gly 
465                 470                 475                 480 


Ala Arg Pro Pro Gly Phe Pro Val Leu Ser Gly Asp Phe Phe Ser Tyr 
                485                 490                 495     


Ala Asp Arg Glu Asp His Tyr Trp Thr Gly Tyr Tyr Thr Ser Arg Pro 
            500                 505                 510         


Phe Tyr Lys Ser Leu Asp Arg Val Leu Glu Ala His Leu Arg Gly Ala 
        515                 520                 525             


Glu Val Leu Tyr Ser Leu Ala Ala Ala His Ala Arg Arg Ser Gly Leu 
    530                 535                 540                 


Ala Gly Arg Tyr Pro Leu Ser Asp Phe Thr Leu Leu Thr Glu Ala Arg 
545                 550                 555                 560 


Arg Thr Leu Gly Leu Phe Gln His His Asp Ala Ile Thr Gly Thr Ala 
                565                 570                 575     


Lys Glu Ala Val Val Val Asp Tyr Gly Val Arg Leu Leu Arg Ser Leu 
            580                 585                 590         


Val Asn Leu Lys Gln Val Ile Ile His Ala Ala His Tyr Leu Val Leu 
        595                 600                 605             


Gly Asp Lys Glu Thr Tyr His Phe Asp Pro Glu Ala Pro Phe Leu Gln 
    610                 615                 620                 


Val Asp Asp Thr Arg Leu Ser His Asp Ala Leu Pro Glu Arg Thr Val 
625                 630                 635                 640 


Ile Gln Leu Asp Ser Ser Pro Arg Phe Val Val Leu Phe Asn Pro Leu 
                645                 650                 655     


Glu Gln Glu Arg Phe Ser Met Val Ser Leu Leu Val Asn Ser Pro Arg 
            660                 665                 670         


Val Arg Val Leu Ser Glu Glu Gly Gln Pro Leu Ala Val Gln Ile Ser 
        675                 680                 685             


Ala His Trp Ser Ser Ala Thr Glu Ala Val Pro Asp Val Tyr Gln Val 
    690                 695                 700                 


Ser Val Pro Val Arg Leu Pro Ala Leu Gly Leu Gly Val Leu Gln Leu 
705                 710                 715                 720 


Gln Leu Gly Leu Asp Gly His Arg Thr Leu Pro Ser Ser Val Arg Ile 
                725                 730                 735     


Tyr Leu His Gly Arg Gln Leu Ser Val Ser Arg His Glu Ala Phe Pro 
            740                 745                 750         


Leu Arg Val Ile Asp Ser Gly Thr Ser Asp Phe Ala Leu Ser Asn Arg 
        755                 760                 765             


Tyr Met Gln Val Trp Phe Ser Gly Leu Thr Gly Leu Leu Lys Ser Ile 
    770                 775                 780                 


Arg Arg Val Asp Glu Glu His Glu Gln Gln Val Asp Met Gln Val Leu 
785                 790                 795                 800 


Val Tyr Gly Thr Arg Thr Ser Lys Asp Lys Ser Gly Ala Tyr Leu Phe 
                805                 810                 815     


Leu Pro Asp Gly Glu Ala Lys Pro Tyr Val Pro Lys Glu Pro Pro Val 
            820                 825                 830         


Leu Arg Val Thr Glu Gly Pro Phe Phe Ser Glu Val Val Ala Tyr Tyr 
        835                 840                 845             


Glu His Ile His Gln Ala Val Arg Leu Tyr Asn Leu Pro Gly Val Glu 
    850                 855                 860                 


Gly Leu Ser Leu Asp Ile Ser Ser Leu Val Asp Ile Arg Asp Tyr Val 
865                 870                 875                 880 


Asn Lys Glu Leu Ala Leu His Ile His Thr Asp Ile Asp Ser Gln Gly 
                885                 890                 895     


Ile Phe Phe Thr Asp Leu Asn Gly Phe Gln Val Gln Pro Arg Arg Tyr 
            900                 905                 910         


Leu Lys Lys Leu Pro Leu Gln Ala Asn Phe Tyr Pro Met Pro Val Met 
        915                 920                 925             


Ala Tyr Ile Gln Asp Ala Gln Lys Arg Leu Thr Leu His Thr Ala Gln 
    930                 935                 940                 


Ala Leu Gly Val Ser Ser Leu Lys Asp Gly Gln Leu Glu Val Ile Leu 
945                 950                 955                 960 


Asp Arg Arg Leu Met Gln Asp Asp Asn Arg Gly Leu Gly Gln Gly Leu 
                965                 970                 975     


Lys Asp Asn Lys Arg Thr Cys Asn Arg Phe Arg Leu Leu Leu Glu Arg 
            980                 985                 990         


Arg Thr Val Gly Ser Glu Val Gln  Asp Ser His Ser Thr  Ser Tyr Pro 
        995                 1000                 1005             


Ser Leu  Leu Ser His Leu Thr  Ser Met Tyr Leu Asn  Ala Pro Ala 
    1010                 1015                 1020             


Leu Ala  Leu Pro Val Ala Arg  Met Gln Leu Pro Gly  Pro Gly Leu 
    1025                 1030                 1035             


Arg Ser  Phe His Pro Leu Ala  Ser Ser Leu Pro Cys  Asp Phe His 
    1040                 1045                 1050             


Leu Leu  Asn Leu Arg Thr Leu  Gln Ala Glu Glu Asp  Thr Leu Pro 
    1055                 1060                 1065             


Ser Ala  Glu Thr Ala Leu Ile  Leu His Arg Lys Gly  Phe Asp Cys 
    1070                 1075                 1080             


Gly Leu  Glu Ala Lys Asn Leu  Gly Phe Asn Cys Thr  Thr Ser Gln 
    1085                 1090                 1095             


Gly Lys  Val Ala Leu Gly Ser  Leu Phe His Gly Leu  Asp Val Val 
    1100                 1105                 1110             


Phe Leu  Gln Pro Thr Ser Leu  Thr Leu Leu Tyr Pro  Leu Ala Ser 
    1115                 1120                 1125             


Pro Ser  Asn Ser Thr Asp Val  Tyr Leu Glu Pro Met  Glu Ile Ala 
    1130                 1135                 1140             


Thr Phe  Arg Leu Arg Leu Gly  
    1145                 1150 


<210>  3346
<211>  1089
<212>  DNA
<213>  Homosapiens

<400>  3346
ccacgcgtcc gcccacgcgt ccgcgcgcga tgggctctga ggcggcgcag ctgctggagg     60

ctgccgactt cgcggctcgc aagcaccggc agcagcggcg gaaggacccc gaggggaccc    120

cctacatcaa ccaccccatc ggtgtggcac ggatcctgac ccacgaggcg ggaatcactg    180

acattgtggt gttacaggcg gccctgctcc atgacacggt ggaggacaca gacaccaccc    240

tggatgaggt ggagctacac tttggggcac aagtgcggcg cctggtggag gaggtaacag    300

atgacaagac tctgcccaag ctggagagaa agaggctgca ggtggagcaa gcgccccaca    360

gtagccccgg ggccaaactg gtgaagctgg cagacaagct gtacaatctg agggacctga    420

atcgctgcac cccagaggta aaaatacaat agctgggcca aggggaagtt ttcaggacag    480

ctcattgcat caggaactca tggccttgaa ccaagcttgc caggaagtgg ggaaaaggca    540

gtgctttcct tgacatcacg ctagcaagtt tctgtcgact cttatgcagg atggtcagaa    600

catcgagtcc aggaatactt cgagtgggca gcgcaggtgg tgaaggggct tcagggaaca    660

aaccggcaac tggaagaggc tctaaagcat ctgttcaagc agcgggggct gacaatctga    720

tcagtgcttg aagctatcca gaggcacaac tccagcctcg ttcaggccgg acaggattca    780

tacgccatct tttctgtgtc tcctgagctc cctccatcct tcccagatat tagaggccaa    840

aaaaagactt gcattttttc tcagtctgaa ggtctcctgc taactaagct gagccccgcg    900

tggtgggaat cagatgtacc catccatttc tgatgcactc accgcctctc cccaagtctt    960

gggtctgttt gctattttgc atggtggggt ctctggcccc tcagggactt gagattattt   1020

aagtactagt tcctaacacg ttctggaaaa taaaaataac tctgggttaa aaaaaaaaaa   1080

aaaaaaaaa                                                           1089


<210>  3347
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  3347

Met Gly Ser Glu Ala Ala Gln Leu Leu Glu Ala Ala Asp Phe Ala Ala 
1               5                   10                  15      


Arg Lys His Arg Gln Gln Arg Arg Lys Asp Pro Glu Gly Thr Pro Tyr 
            20                  25                  30          


Ile Asn His Pro Ile Gly Val Ala Arg Ile Leu Thr His Glu Ala Gly 
        35                  40                  45              


Ile Thr Asp Ile Val Val Leu Gln Ala Ala Leu Leu His Asp Thr Val 
    50                  55                  60                  


Glu Asp Thr Asp Thr Thr Leu Asp Glu Val Glu Leu His Phe Gly Ala 
65                  70                  75                  80  


Gln Val Arg Arg Leu Val Glu Glu Val Thr Asp Asp Lys Thr Leu Pro 
                85                  90                  95      


Lys Leu Glu Arg Lys Arg Leu Gln Val Glu Gln Ala Pro His Ser Ser 
            100                 105                 110         


Pro Gly Ala Lys Leu Val Lys Leu Ala Asp Lys Leu Tyr Asn Leu Arg 
        115                 120                 125             


Asp Leu Asn Arg Cys Thr Pro Glu Val Lys Ile Gln 
    130                 135                 140 


<210>  3348
<211>  4035
<212>  DNA
<213>  Homosapiens

<400>  3348
acttaacaac cgaagtaacc cgcaatgcgg aagggcgagg ggattgcgag tcaccgagtt     60

tcccgcgcgg cttgagtcac ggcctagaaa gagagatgtt ggggttccca ggaccaggac    120

agaggtggta gtgaactctc atgggcatcc agagaaggtc aggccccttg ctgacaggcc    180

tatctgtggg gctactgctg ctcttcagct gggtgaccct tgtccagcca acctctctct    240

cagctctggt ccaccaccct cacttgtgcc agaccacccg ggatgtccat ggccgtcact    300

accctggttt cttttgccct cgtctgtctg attctccaga ggaagcctac tgctgccacc    360

tgcaggctgc agggggctcc tgctgcaccc gggctgaatt tgaggccctg taccaagtca    420

atctgtccgc tcttccgccc ccgcccatcc tcaggggccc aggcccgctc ctagtgctgg    480

gcctctacaa cctactggtt gtgaccctga tgaccgtaga cctcgtgcac ttctgctgcg    540

gtcggggccg gagtctgggc tggagccacc gcaggcctcc ctctgggtcc tccgccgcga    600

gctccctgca ggtctctgcg gggacagctt aggtgcgccc ggagcttgcc tgcacctgcg    660

atccagagcc aagcgccccg cccctgcccg ggcgcgctcc ctccttagcc ctgcccctct    720

ctgaccccac ctccgacgca agagtggggc ggggcagctg ccggtggcgt cccgaaccca    780

gactcgcccc gccccagaga ctgcgcctgc gcgggcacga gacaacctct ccgcgatgac    840

tgccagctca gtggagcagc tgcggaagga gggcaatgag ctgttcaaat gtggagacta    900

cgggggcgcc ctggcggcct acactcaggc cctgggtctg gacgcgacgc cccaggacca    960

ggccgttctg caccggaacc gggccgcctg ccacctcaag ctggaagatt acgacaaagc   1020

agaaacagag gcatccaaag ccattgaaaa ggatggtggg gatgtcaaag cactctaccg   1080

gcggagccaa gccctagaga agctgggccg cctggaccag gctgtccttg acctgcagag   1140

atgtgtgagc ttggagccca agaacaaagt tttccaggag gccttgcgga acatcggggg   1200

ccagattcag gagaaggtgc gatacatgtc ctcgacggat gccaaagtgg aacagatgtt   1260

tcagatactg ttggacccag aagagaaggg cactgagaaa aagcaaaagg cttctcagaa   1320

cctggtggtg ctggccaggg aggatgctgg agcggagaag atcttccgga gtaatggggt   1380

tcagctcttg caacgtttac tggacatggg agagactgac ctcatgctgg cggctctgcg   1440

tacgctggtt ggcatttgct ctgagcatca gtcacggaca gtggcaaccc tgagcatact   1500

gggaactcgg cgagtagtct ccatcctggg cgtggaaagc caggctgtgt ccctggctgc   1560

ctgccacctg ctgcaggtta tgtttgatgc cctcaaggaa ggtgtcaaaa aaggcttccg   1620

aggcaaagaa ggtgccatca ttgtggatcc tgcccgggag ctgaaggtcc tcatcagtaa   1680

cctcttagat ctgctgacag aggtgggggt ctctggccaa ggccgagaca atgccctgac   1740

cctcctgatt aaagcggtgc cccggaagtc tctcaaggac cccaacaaca gcctcaccct   1800

ctgggtcatc gaccaaggtc tgaaaaagat tttggaagtg gggggctctc tacaggaccc   1860

tcctggggag ctcgcagtga ccgcaaacag ccgcatgagc gcctctattc tcctcagcaa   1920

gctctttgat gacctcaagt gtgatgcgga gagggagaat ttccacagac tttgtgaaaa   1980

ctacatcaag agctggtttg agggccaagg gctggccggg aagctacggg ccatccagac   2040

ggtgtcctgc ctcctgcagg gcccatgtga cgctggcaac cgggccttgg agctgagcgg   2100

tgtcatggag agtgtgattg ctctgtgtgc ctctgagcag gaggaggagc agctggtggc   2160

cgtggaggct ctgatccatg cagccggcaa ggctaagcgg gcctcattca tcactgccaa   2220

tggtgtctcg ctgctgaagg acctatataa gtgcagcgag aaggacagca tccgcatccg   2280

ggcgctagtg ggactctgta agctcggttc ggctggaggg actgacttca gcatgaagca   2340

gtttgctgaa ggctccactc tcaaactggc taagcagtgt cgaaagtggc tgtgcaatga   2400

ccagatcgac gcaggcactc ggcgctgggc agtggagggc ctggcttacc tgacctttga   2460

tgccgacgtg aaggaagagt ttgtggagga tgcggctgct ctgaaagctc tgttccagct   2520

cagcaggttg gaggagaggt cagtgctctt tgcggtggcc tcagcgctgg tgaactgcac   2580

caacagctat gactacgagg agcccgaccc caagatggtg gagctggcca agtatgccaa   2640

gcagcatgtg cccgagcagc accccaagga caagccaagc ttcgtgcggg ctcgggtgaa   2700

gaagctgctg gcagcgggtg tggtgtcggc catggtgtgc atggtgaaga cggagagccc   2760

tgtgctgacc agttcctgca gagagctgct ctccagggtc ttcttggctt tagtggaaga   2820

ggtagaggac cgaggcactg tggttgccca gggaggcggc agggcgctga tcccgctggc   2880

cctggaaggc acggacgtgg ggcagacaaa ggcagcccag gcccttgcca agctcaccat   2940

cacctccaac ccggagatga ccttccctgg cgagcggatc tatgaggtgg tccggcccct   3000

cgtctccctg ttgcacctca actgctcagg cctgcagaac ttcgaggcgc tcatggccct   3060

aacaaacctg gctgggatca gcgagaggct ccggcagaag atcctgaagg agaaggctgt   3120

gcccatgata gaaggctaca tgtttgagga gcatgagatg atccgccggg cagccacgga   3180

gtgcatgtgt aacttggcca tgagcaagga ggtgcaggac ctcttcgaag cccagggcaa   3240

tgaccgactg aagctgctgg tgctgtacag tggagaggat gatgagctgc tacagcgggc   3300

agctgccggg ggcttggcca tgcttacctc catgcggccc acgctctgca gccgcattcc   3360

ccaagtgacc acacactggc tggagatcct gcaggccctg cttctgagct ccaaccagga   3420

gctgcagcac cggggtgctg tggtggtgct gaacatggtg gaggcctcga gggagattgc   3480

cagcaccctg atggagagtg agatgatgga gatcttgtca gtgctagcta agggtgacca   3540

cagccctgtc acaagggctg ctgcagcctg cctggacaaa gcagtggaat atgggcttat   3600

ccaacccaac caagatggag agtgaggggg ttgtccctgg gcccaaggct catgcacacg   3660

ctacctattg tggcacggag agtaaggacg gaagcagctt tggctggtgg tggctggcat   3720

gcccaatact cttgcccatc ctcgcttgct gccctaggat gtcctctgtt ctgagtcagc   3780

ggccacgttc agtcacacag ccctgcttgg ccagcactgc ctgcagcctc actcagaggg   3840

gccctttttc tgtactactg tagtcagctg ggaatgggga aggtgcatcc caacacagcc   3900

tgtggatcct ggggcatctg gaagggcgca cacatcagca gcctcaccag ctgtgagcct   3960

gctatcaggc ctgcccctcc aataaaagtg tgtagaactc caaaaaaaaa aaaaaaaaaa   4020

aaaaaaaaaa aaaaa                                                    4035


<210>  3349
<211>  929
<212>  PRT
<213>  Homosapiens

<400>  3349

Met Thr Ala Ser Ser Val Glu Gln Leu Arg Lys Glu Gly Asn Glu Leu 
1               5                   10                  15      


Phe Lys Cys Gly Asp Tyr Gly Gly Ala Leu Ala Ala Tyr Thr Gln Ala 
            20                  25                  30          


Leu Gly Leu Asp Ala Thr Pro Gln Asp Gln Ala Val Leu His Arg Asn 
        35                  40                  45              


Arg Ala Ala Cys His Leu Lys Leu Glu Asp Tyr Asp Lys Ala Glu Thr 
    50                  55                  60                  


Glu Ala Ser Lys Ala Ile Glu Lys Asp Gly Gly Asp Val Lys Ala Leu 
65                  70                  75                  80  


Tyr Arg Arg Ser Gln Ala Leu Glu Lys Leu Gly Arg Leu Asp Gln Ala 
                85                  90                  95      


Val Leu Asp Leu Gln Arg Cys Val Ser Leu Glu Pro Lys Asn Lys Val 
            100                 105                 110         


Phe Gln Glu Ala Leu Arg Asn Ile Gly Gly Gln Ile Gln Glu Lys Val 
        115                 120                 125             


Arg Tyr Met Ser Ser Thr Asp Ala Lys Val Glu Gln Met Phe Gln Ile 
    130                 135                 140                 


Leu Leu Asp Pro Glu Glu Lys Gly Thr Glu Lys Lys Gln Lys Ala Ser 
145                 150                 155                 160 


Gln Asn Leu Val Val Leu Ala Arg Glu Asp Ala Gly Ala Glu Lys Ile 
                165                 170                 175     


Phe Arg Ser Asn Gly Val Gln Leu Leu Gln Arg Leu Leu Asp Met Gly 
            180                 185                 190         


Glu Thr Asp Leu Met Leu Ala Ala Leu Arg Thr Leu Val Gly Ile Cys 
        195                 200                 205             


Ser Glu His Gln Ser Arg Thr Val Ala Thr Leu Ser Ile Leu Gly Thr 
    210                 215                 220                 


Arg Arg Val Val Ser Ile Leu Gly Val Glu Ser Gln Ala Val Ser Leu 
225                 230                 235                 240 


Ala Ala Cys His Leu Leu Gln Val Met Phe Asp Ala Leu Lys Glu Gly 
                245                 250                 255     


Val Lys Lys Gly Phe Arg Gly Lys Glu Gly Ala Ile Ile Val Asp Pro 
            260                 265                 270         


Ala Arg Glu Leu Lys Val Leu Ile Ser Asn Leu Leu Asp Leu Leu Thr 
        275                 280                 285             


Glu Val Gly Val Ser Gly Gln Gly Arg Asp Asn Ala Leu Thr Leu Leu 
    290                 295                 300                 


Ile Lys Ala Val Pro Arg Lys Ser Leu Lys Asp Pro Asn Asn Ser Leu 
305                 310                 315                 320 


Thr Leu Trp Val Ile Asp Gln Gly Leu Lys Lys Ile Leu Glu Val Gly 
                325                 330                 335     


Gly Ser Leu Gln Asp Pro Pro Gly Glu Leu Ala Val Thr Ala Asn Ser 
            340                 345                 350         


Arg Met Ser Ala Ser Ile Leu Leu Ser Lys Leu Phe Asp Asp Leu Lys 
        355                 360                 365             


Cys Asp Ala Glu Arg Glu Asn Phe His Arg Leu Cys Glu Asn Tyr Ile 
    370                 375                 380                 


Lys Ser Trp Phe Glu Gly Gln Gly Leu Ala Gly Lys Leu Arg Ala Ile 
385                 390                 395                 400 


Gln Thr Val Ser Cys Leu Leu Gln Gly Pro Cys Asp Ala Gly Asn Arg 
                405                 410                 415     


Ala Leu Glu Leu Ser Gly Val Met Glu Ser Val Ile Ala Leu Cys Ala 
            420                 425                 430         


Ser Glu Gln Glu Glu Glu Gln Leu Val Ala Val Glu Ala Leu Ile His 
        435                 440                 445             


Ala Ala Gly Lys Ala Lys Arg Ala Ser Phe Ile Thr Ala Asn Gly Val 
    450                 455                 460                 


Ser Leu Leu Lys Asp Leu Tyr Lys Cys Ser Glu Lys Asp Ser Ile Arg 
465                 470                 475                 480 


Ile Arg Ala Leu Val Gly Leu Cys Lys Leu Gly Ser Ala Gly Gly Thr 
                485                 490                 495     


Asp Phe Ser Met Lys Gln Phe Ala Glu Gly Ser Thr Leu Lys Leu Ala 
            500                 505                 510         


Lys Gln Cys Arg Lys Trp Leu Cys Asn Asp Gln Ile Asp Ala Gly Thr 
        515                 520                 525             


Arg Arg Trp Ala Val Glu Gly Leu Ala Tyr Leu Thr Phe Asp Ala Asp 
    530                 535                 540                 


Val Lys Glu Glu Phe Val Glu Asp Ala Ala Ala Leu Lys Ala Leu Phe 
545                 550                 555                 560 


Gln Leu Ser Arg Leu Glu Glu Arg Ser Val Leu Phe Ala Val Ala Ser 
                565                 570                 575     


Ala Leu Val Asn Cys Thr Asn Ser Tyr Asp Tyr Glu Glu Pro Asp Pro 
            580                 585                 590         


Lys Met Val Glu Leu Ala Lys Tyr Ala Lys Gln His Val Pro Glu Gln 
        595                 600                 605             


His Pro Lys Asp Lys Pro Ser Phe Val Arg Ala Arg Val Lys Lys Leu 
    610                 615                 620                 


Leu Ala Ala Gly Val Val Ser Ala Met Val Cys Met Val Lys Thr Glu 
625                 630                 635                 640 


Ser Pro Val Leu Thr Ser Ser Cys Arg Glu Leu Leu Ser Arg Val Phe 
                645                 650                 655     


Leu Ala Leu Val Glu Glu Val Glu Asp Arg Gly Thr Val Val Ala Gln 
            660                 665                 670         


Gly Gly Gly Arg Ala Leu Ile Pro Leu Ala Leu Glu Gly Thr Asp Val 
        675                 680                 685             


Gly Gln Thr Lys Ala Ala Gln Ala Leu Ala Lys Leu Thr Ile Thr Ser 
    690                 695                 700                 


Asn Pro Glu Met Thr Phe Pro Gly Glu Arg Ile Tyr Glu Val Val Arg 
705                 710                 715                 720 


Pro Leu Val Ser Leu Leu His Leu Asn Cys Ser Gly Leu Gln Asn Phe 
                725                 730                 735     


Glu Ala Leu Met Ala Leu Thr Asn Leu Ala Gly Ile Ser Glu Arg Leu 
            740                 745                 750         


Arg Gln Lys Ile Leu Lys Glu Lys Ala Val Pro Met Ile Glu Gly Tyr 
        755                 760                 765             


Met Phe Glu Glu His Glu Met Ile Arg Arg Ala Ala Thr Glu Cys Met 
    770                 775                 780                 


Cys Asn Leu Ala Met Ser Lys Glu Val Gln Asp Leu Phe Glu Ala Gln 
785                 790                 795                 800 


Gly Asn Asp Arg Leu Lys Leu Leu Val Leu Tyr Ser Gly Glu Asp Asp 
                805                 810                 815     


Glu Leu Leu Gln Arg Ala Ala Ala Gly Gly Leu Ala Met Leu Thr Ser 
            820                 825                 830         


Met Arg Pro Thr Leu Cys Ser Arg Ile Pro Gln Val Thr Thr His Trp 
        835                 840                 845             


Leu Glu Ile Leu Gln Ala Leu Leu Leu Ser Ser Asn Gln Glu Leu Gln 
    850                 855                 860                 


His Arg Gly Ala Val Val Val Leu Asn Met Val Glu Ala Ser Arg Glu 
865                 870                 875                 880 


Ile Ala Ser Thr Leu Met Glu Ser Glu Met Met Glu Ile Leu Ser Val 
                885                 890                 895     


Leu Ala Lys Gly Asp His Ser Pro Val Thr Arg Ala Ala Ala Ala Cys 
            900                 905                 910         


Leu Asp Lys Ala Val Glu Tyr Gly Leu Ile Gln Pro Asn Gln Asp Gly 
        915                 920                 925             


Glu 
    


<210>  3350
<211>  3585
<212>  DNA
<213>  Homosapiens

<400>  3350
tggttgtgac cctgatgacc gtagacctcg tgcacttctg ctgcggtcgg ggccggagtc     60

tgggctggag ccaccgcagg cctccctctg ggtcctccgc cgcgagctcc ctgcaggtct    120

ctgcggggac agcttaggtg cgcccggagc ttgcctgcac ctgcgatcca gagccaagcg    180

ccccgcccct gcccgggcgc gctccctcct tagccctgcc cctctctgac cccacctccg    240

acgcaagagt ggggcggggc agctgccggt ggcgtcccga acccagactc gccccgcccc    300

agagactgcg cctgcgcggg cacgagacaa cctctccgcg atgactgtga gtggtccagg    360

gacccccgag ccccggccgg ccacccccgg ggccagctca gtggagcagc tgcggaagga    420

gggcaatgag ctgttcaaat gtggagacta cgggggcgcc ctggcggcct acactcaggc    480

cctgggtctg gacgcgacgc cccaggacca ggccgttctg caccggaacc gggccgcctg    540

ccacctcaag ctggaagatt acgacaaagc agaaacagag gcatccaaag ccattgaaaa    600

ggatggtggg gatgtcaaag cactctaccg gcggagccaa gccctagaga agctgggccg    660

cctggaccag gctgtccttg acctgcagag atgtgtgagc ttggagccca agaacaaagt    720

tttccaggag gccttgcgga acatcggggg ccagattcag gagaaggtgc gatacatgtc    780

ctcgacggat gccaaagtgg aacagatgtt tcagatactg ttggacccag aagagaaggg    840

cactgagaaa aagcaaaagg cttctcagaa cctggtggtg ctggccaggg aggatgctgg    900

agcggagaag atcttccgga gtaatggggt tcagctcttg caacgtttac tggacatggg    960

agagactgac ctcatgctgg cggctctgcg tacgctggtt ggcatttgct ctgagcatca   1020

gtcacggaca gtggcaaccc tgagcatact gggaactcgg cgagtagtct ccatcctggg   1080

cgtggaaagc caggctgtgt ccctggctgc ctgccacctg ctgcaggtta tgtttgatgc   1140

cctcaaggaa ggtgtcaaaa aaggcttccg aggcaaagaa ggtgccatca ttgtggatcc   1200

tgcccgggag ctgaaggtcc tcatcagtaa cctcttagat ctgctgacag aggtgggggt   1260

ctctggccaa ggccgagaca atgccctgac cctcctgatt aaagcggtgc cccggaagtc   1320

tctcaaggac cccaacaaca gcctcaccct ctgggtcatc gaccaaggtc tgaaaaagat   1380

tttggaagtg gggggctctc tacaggaccc tcctggggag ctcgcagtga ccgcaaacag   1440

ccgcatgagc gcctctattc tcctcagcaa gctctttgat gacctcaagt gtgatgcgga   1500

gagggagaat ttccacagac tttgtgaaaa ctacatcaag agctggtttg agggccaagg   1560

gctggccggg aagctacggg ccatccagac ggtgtcctgc ctcctgcagg gcccatgtga   1620

cgctggcaac cgggccttgg agctgagcgg tgtcatggag agtgtgattg ctctgtgtgc   1680

ctctgagcag gaggaggagc agctggtggc cgtggaggct ctgatccatg cagccggcaa   1740

ggctaagcgg gcctcattca tcactgccaa tggtgtctcg ctgctgaagg acctatataa   1800

gtgcagcgag aaggacagca tccgcatccg ggcgctagtg ggactctgta agctcggttc   1860

ggctggaggg actgacttca gcatgaagca gtttgctgaa ggctccactc tcaaactggc   1920

taagcagtgt cgaaagtggc tgtgcaatga ccagatcgac gcaggcactc ggcgctgggc   1980

agtggagggc ctggcttacc tgacctttga tgccgacgtg aaggaagagt ttgtggagga   2040

tgcggctgct ctgaaagctc tgttccagct cagcaggttg gaggagaggt cagtgctctt   2100

tgcggtggcc tcagcgctgg tgaactgcac caacagctat gactacgagg agcccgaccc   2160

caagatggtg gagctggcca agtatgccaa gcagcatgtg cccgagcagc accccaagga   2220

caagccaagc ttcgtgcggg ctcgggtgaa gaagctgctg gcagcgggtg tggtgtcggc   2280

catggtgtgc atggtgaaga cggagagccc tgtgctgacc agttcctgca gagagctgct   2340

ctccagggtc ttcttggctt tagtggaaga ggtagaggac cgaggcactg tggttgccca   2400

gggaggcggc agggcgctga tcccgctggc cctggaaggc acggacgtgg ggcagacaaa   2460

ggcagcccag gcccttgcca agctcaccat cacctccaac ccggagatga ccttccctgg   2520

cgagcggatc tatgaggtgg tccggcccct cgtctccctg ttgcacctca actgctcagg   2580

cctgcagaac ttcgaggcgc tcatggccct aacaaacctg gctgggatca gcgagaggct   2640

ccggcagaag atcctgaagg agaaggctgt gcccatgata gaaggctaca tgtttgagga   2700

gcatgagatg atccgccggg cagccacgga gtgcatgtgt aacttggcca tgagcaagga   2760

ggtgcaggac ctcttcgaag cccagggcaa tgaccgactg aagctgctgg tgctgtacag   2820

tggagaggat gatgagctgc tacagcgggc agctgccggg ggcttggcca tgcttacctc   2880

catgcggccc acgctctgca gccgcattcc ccaagtgacc acacactggc tggagatcct   2940

gcaggccctg cttctgagct ccaaccagga gctgcagcac cggggtgctg tggtggtgct   3000

gaacatggtg gaggcctcga gggagattgc cagcaccctg atggagagtg agatgatgga   3060

gatcttgtca gtgctagcta agggtgacca cagccctgtc acaagggctg ctgcagcctg   3120

cctggacaaa gcagtggaat atgggcttat ccaacccaac caagatggag agtgaggggg   3180

ttgtccctgg gcccaaggct catgcacacg ctacctattg tggcacggag agtaaggacg   3240

gaagcagctt tggctggtgg tggctggcat gcccaatact cttgcccatc ctcgcttgct   3300

gccctaggat gtcctctgtt ctgagtcagc ggccacgttc agtcacacag ccctgcttgg   3360

ccagcactgc ctgcagcctc actcagaggg gccctttttc tgtactactg tagtcagctg   3420

ggaatgggga aggtgcatcc caacacagcc tgtggatcct ggggcatctg gaagggcgca   3480

cacatcagca gcctcaccag ctgtgagcct gctatcaggc ctgcccctcc aataaaagtg   3540

tgtagaactc caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                   3585


<210>  3351
<211>  944
<212>  PRT
<213>  Homosapiens

<400>  3351

Met Thr Val Ser Gly Pro Gly Thr Pro Glu Pro Arg Pro Ala Thr Pro 
1               5                   10                  15      


Gly Ala Ser Ser Val Glu Gln Leu Arg Lys Glu Gly Asn Glu Leu Phe 
            20                  25                  30          


Lys Cys Gly Asp Tyr Gly Gly Ala Leu Ala Ala Tyr Thr Gln Ala Leu 
        35                  40                  45              


Gly Leu Asp Ala Thr Pro Gln Asp Gln Ala Val Leu His Arg Asn Arg 
    50                  55                  60                  


Ala Ala Cys His Leu Lys Leu Glu Asp Tyr Asp Lys Ala Glu Thr Glu 
65                  70                  75                  80  


Ala Ser Lys Ala Ile Glu Lys Asp Gly Gly Asp Val Lys Ala Leu Tyr 
                85                  90                  95      


Arg Arg Ser Gln Ala Leu Glu Lys Leu Gly Arg Leu Asp Gln Ala Val 
            100                 105                 110         


Leu Asp Leu Gln Arg Cys Val Ser Leu Glu Pro Lys Asn Lys Val Phe 
        115                 120                 125             


Gln Glu Ala Leu Arg Asn Ile Gly Gly Gln Ile Gln Glu Lys Val Arg 
    130                 135                 140                 


Tyr Met Ser Ser Thr Asp Ala Lys Val Glu Gln Met Phe Gln Ile Leu 
145                 150                 155                 160 


Leu Asp Pro Glu Glu Lys Gly Thr Glu Lys Lys Gln Lys Ala Ser Gln 
                165                 170                 175     


Asn Leu Val Val Leu Ala Arg Glu Asp Ala Gly Ala Glu Lys Ile Phe 
            180                 185                 190         


Arg Ser Asn Gly Val Gln Leu Leu Gln Arg Leu Leu Asp Met Gly Glu 
        195                 200                 205             


Thr Asp Leu Met Leu Ala Ala Leu Arg Thr Leu Val Gly Ile Cys Ser 
    210                 215                 220                 


Glu His Gln Ser Arg Thr Val Ala Thr Leu Ser Ile Leu Gly Thr Arg 
225                 230                 235                 240 


Arg Val Val Ser Ile Leu Gly Val Glu Ser Gln Ala Val Ser Leu Ala 
                245                 250                 255     


Ala Cys His Leu Leu Gln Val Met Phe Asp Ala Leu Lys Glu Gly Val 
            260                 265                 270         


Lys Lys Gly Phe Arg Gly Lys Glu Gly Ala Ile Ile Val Asp Pro Ala 
        275                 280                 285             


Arg Glu Leu Lys Val Leu Ile Ser Asn Leu Leu Asp Leu Leu Thr Glu 
    290                 295                 300                 


Val Gly Val Ser Gly Gln Gly Arg Asp Asn Ala Leu Thr Leu Leu Ile 
305                 310                 315                 320 


Lys Ala Val Pro Arg Lys Ser Leu Lys Asp Pro Asn Asn Ser Leu Thr 
                325                 330                 335     


Leu Trp Val Ile Asp Gln Gly Leu Lys Lys Ile Leu Glu Val Gly Gly 
            340                 345                 350         


Ser Leu Gln Asp Pro Pro Gly Glu Leu Ala Val Thr Ala Asn Ser Arg 
        355                 360                 365             


Met Ser Ala Ser Ile Leu Leu Ser Lys Leu Phe Asp Asp Leu Lys Cys 
    370                 375                 380                 


Asp Ala Glu Arg Glu Asn Phe His Arg Leu Cys Glu Asn Tyr Ile Lys 
385                 390                 395                 400 


Ser Trp Phe Glu Gly Gln Gly Leu Ala Gly Lys Leu Arg Ala Ile Gln 
                405                 410                 415     


Thr Val Ser Cys Leu Leu Gln Gly Pro Cys Asp Ala Gly Asn Arg Ala 
            420                 425                 430         


Leu Glu Leu Ser Gly Val Met Glu Ser Val Ile Ala Leu Cys Ala Ser 
        435                 440                 445             


Glu Gln Glu Glu Glu Gln Leu Val Ala Val Glu Ala Leu Ile His Ala 
    450                 455                 460                 


Ala Gly Lys Ala Lys Arg Ala Ser Phe Ile Thr Ala Asn Gly Val Ser 
465                 470                 475                 480 


Leu Leu Lys Asp Leu Tyr Lys Cys Ser Glu Lys Asp Ser Ile Arg Ile 
                485                 490                 495     


Arg Ala Leu Val Gly Leu Cys Lys Leu Gly Ser Ala Gly Gly Thr Asp 
            500                 505                 510         


Phe Ser Met Lys Gln Phe Ala Glu Gly Ser Thr Leu Lys Leu Ala Lys 
        515                 520                 525             


Gln Cys Arg Lys Trp Leu Cys Asn Asp Gln Ile Asp Ala Gly Thr Arg 
    530                 535                 540                 


Arg Trp Ala Val Glu Gly Leu Ala Tyr Leu Thr Phe Asp Ala Asp Val 
545                 550                 555                 560 


Lys Glu Glu Phe Val Glu Asp Ala Ala Ala Leu Lys Ala Leu Phe Gln 
                565                 570                 575     


Leu Ser Arg Leu Glu Glu Arg Ser Val Leu Phe Ala Val Ala Ser Ala 
            580                 585                 590         


Leu Val Asn Cys Thr Asn Ser Tyr Asp Tyr Glu Glu Pro Asp Pro Lys 
        595                 600                 605             


Met Val Glu Leu Ala Lys Tyr Ala Lys Gln His Val Pro Glu Gln His 
    610                 615                 620                 


Pro Lys Asp Lys Pro Ser Phe Val Arg Ala Arg Val Lys Lys Leu Leu 
625                 630                 635                 640 


Ala Ala Gly Val Val Ser Ala Met Val Cys Met Val Lys Thr Glu Ser 
                645                 650                 655     


Pro Val Leu Thr Ser Ser Cys Arg Glu Leu Leu Ser Arg Val Phe Leu 
            660                 665                 670         


Ala Leu Val Glu Glu Val Glu Asp Arg Gly Thr Val Val Ala Gln Gly 
        675                 680                 685             


Gly Gly Arg Ala Leu Ile Pro Leu Ala Leu Glu Gly Thr Asp Val Gly 
    690                 695                 700                 


Gln Thr Lys Ala Ala Gln Ala Leu Ala Lys Leu Thr Ile Thr Ser Asn 
705                 710                 715                 720 


Pro Glu Met Thr Phe Pro Gly Glu Arg Ile Tyr Glu Val Val Arg Pro 
                725                 730                 735     


Leu Val Ser Leu Leu His Leu Asn Cys Ser Gly Leu Gln Asn Phe Glu 
            740                 745                 750         


Ala Leu Met Ala Leu Thr Asn Leu Ala Gly Ile Ser Glu Arg Leu Arg 
        755                 760                 765             


Gln Lys Ile Leu Lys Glu Lys Ala Val Pro Met Ile Glu Gly Tyr Met 
    770                 775                 780                 


Phe Glu Glu His Glu Met Ile Arg Arg Ala Ala Thr Glu Cys Met Cys 
785                 790                 795                 800 


Asn Leu Ala Met Ser Lys Glu Val Gln Asp Leu Phe Glu Ala Gln Gly 
                805                 810                 815     


Asn Asp Arg Leu Lys Leu Leu Val Leu Tyr Ser Gly Glu Asp Asp Glu 
            820                 825                 830         


Leu Leu Gln Arg Ala Ala Ala Gly Gly Leu Ala Met Leu Thr Ser Met 
        835                 840                 845             


Arg Pro Thr Leu Cys Ser Arg Ile Pro Gln Val Thr Thr His Trp Leu 
    850                 855                 860                 


Glu Ile Leu Gln Ala Leu Leu Leu Ser Ser Asn Gln Glu Leu Gln His 
865                 870                 875                 880 


Arg Gly Ala Val Val Val Leu Asn Met Val Glu Ala Ser Arg Glu Ile 
                885                 890                 895     


Ala Ser Thr Leu Met Glu Ser Glu Met Met Glu Ile Leu Ser Val Leu 
            900                 905                 910         


Ala Lys Gly Asp His Ser Pro Val Thr Arg Ala Ala Ala Ala Cys Leu 
        915                 920                 925             


Asp Lys Ala Val Glu Tyr Gly Leu Ile Gln Pro Asn Gln Asp Gly Glu 
    930                 935                 940                 


<210>  3352
<211>  2690
<212>  DNA
<213>  Homosapiens

<400>  3352
taaaagctgc ttcctgttgg ggcatgagtc cggcgcgtgt cgggttttga gctgccgcgg     60

tcccgggact gagataaggc agctccagcc cctggaaggc cagagacttg ccagtgtccc    120

actagcgggc tcttcgcaag aatccccccg ggcccgccgc agccaggcgg cggccggcag    180

agggcgctgc tcgggcatgg cggaggagcg gccgggggcc tggttcggct tcggtttctg    240

cggcttcggg caggagctgg gctccggacg cgggcgccag gtgcacagcc ccagtccgct    300

gcgggcgggc gtcgacatct gccgcgtgag cgcgagctgg agctacaccg ctttcgtgac    360

ccgtggaggc cgcttggagc tgtcgggctc agccagcggc gcggcgggcc gctgcaagga    420

cgcgtgggcc tcggaggggc tcctcgcggt gctgcgcgcc gggccggggc cggaggcgtt    480

actgcaggtc tgggcggccg aatcggcgct gcgtggggag ccattgtggg cccagaatgt    540

ggtgcccgag gccgaagggg aagacgatcc ggccggtgag gcccaggctg ggaggctacc    600

cctgctgccc tgcgcccgtg cctacgtgag cccgcgggcg cccttctacc ggcctctggc    660

tccggagctg cgggcacgcc agctggagct gggcgccgag cacgcgttgc tgctggacgc    720

tgctggccag gtgttctcct ggggcggggg caggcatgga cagctgggcc atgggaccct    780

ggaggcagag ctggagccac ggctgttgga ggcgttgcag ggcctagtca tggctgaggt    840

ggccgcgggg ggctggcatt ctgtgtgtgt gagtgagact ggggatattt atatctgggg    900

ctggaatgaa tcagggcagc tggccctgcc caccaggaac ctggcagagg atggagagac    960

tgtcgcaagg gaagccacag aactgaatga agatggttct caggtgaaga gaacgggtgg   1020

ggctgaggat ggagcccctg cccccttcat agctgtccag cccttcccgg cattactgga   1080

tctccccatg ggctcagatg cagtcaaggc cagctgtgga tcccggcaca cagctgtggt   1140

gacacgaaca ggggagctct acacctgggg ctggggtaaa tatggacagc tgggccacga   1200

ggacaccacc agcttggatc ggcctcgccg tgtggaatac tttgtagata agcaactcca   1260

agtaaaggct gtcacctgtg ggccgtggaa cacctacgtg tatgctgtgg agaaagggaa   1320

gagctgacat gtgtacgtat atgtatatgc aacacctgtg agacccccat tcaggtcaag   1380

gaaaaccatt gcctgcaccc caagggcccc atatttgccc ctccccatca cagtcctgcc   1440

cttcaccctc aagcacggtc ctaaacttgt ctgcacttta gaaacacctg gagagcattg   1500

aaaactctgc tgcctaaggt cagcatcaat caaaacaatg aaatcaatga aacaatgaaa   1560

ccagagcttc taggtgtgtg gcctggatag tggtagattc aaagctccac ccacctcatc   1620

ccaggtacat ttgatgtgca gctgagattg gggcacattc caggtcatcg tcttctgtca   1680

gtcatttccc tgctttcgtt tgaattttac cattcttgta tgcagcctta tacgacatag   1740

ttgtgtttgc ttttgagtgt tagataaatg gaatcctgtg tatgtgcttt tgtgtcgttt   1800

ttgtcactca gcattgtata atccatcctt gttgggtcct ggagttcatt tttaatgcta   1860

tatggtgttc tgttgtatga ataatacctc aagtgataca gccttgttga tggtcatttt   1920

tattgtttct gattttggtc attccacata attctttgtg cagtcttctg cacatgtgca   1980

caagttcctt tgcagaacat tgagttgaat tgctaagtca ggagatacct ttaattttac   2040

tagataactg ttgcccccag cagggtgggg tctactgtgg ctaaaatgtc aggtagatgc   2100

acactggttt taattggcat ttccctggat actgatgagg ttgagtagct tttcatttgt   2160

tttggatggc tgggcatggt ggctcacacc tgtagtccca gcactttggg aggctaagca   2220

gggagattgc ttgaggcgaa gagttcatat gtttattggc cacttggagt ttttctgttg   2280

tcaagtgcct gttcaagttt tctggccttt taaaatgttc tgtattttcc ttagtgattt   2340

ttcttttgga tatttcagat acaagtcttt tgagagttag tattcagagt atcttctgct   2400

acaatgtagt ttgtttcagt ctctcttggt attaccaatt ttaatactta ggtgatgctt   2460

actccatgcc aggtaaggct caaagtgctt tacaagtatc aacttatttt gataaaataa   2520

gcttatcagt agttttcttt atagttaaat tctatttgtg catgtgtgtg tctgtggttt   2580

agcaaatgtt tcccacccat ggggtctttt ttattgtggt aaaatatact gaacataaaa   2640

tttatgttca ataaaaaaca aaaattgttt ttaaccattt taaaaaaaaa              2690


<210>  3353
<211>  376
<212>  PRT
<213>  Homosapiens

<400>  3353

Met Ala Glu Glu Arg Pro Gly Ala Trp Phe Gly Phe Gly Phe Cys Gly 
1               5                   10                  15      


Phe Gly Gln Glu Leu Gly Ser Gly Arg Gly Arg Gln Val His Ser Pro 
            20                  25                  30          


Ser Pro Leu Arg Ala Gly Val Asp Ile Cys Arg Val Ser Ala Ser Trp 
        35                  40                  45              


Ser Tyr Thr Ala Phe Val Thr Arg Gly Gly Arg Leu Glu Leu Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Ala Ala Gly Arg Cys Lys Asp Ala Trp Ala Ser Glu 
65                  70                  75                  80  


Gly Leu Leu Ala Val Leu Arg Ala Gly Pro Gly Pro Glu Ala Leu Leu 
                85                  90                  95      


Gln Val Trp Ala Ala Glu Ser Ala Leu Arg Gly Glu Pro Leu Trp Ala 
            100                 105                 110         


Gln Asn Val Val Pro Glu Ala Glu Gly Glu Asp Asp Pro Ala Gly Glu 
        115                 120                 125             


Ala Gln Ala Gly Arg Leu Pro Leu Leu Pro Cys Ala Arg Ala Tyr Val 
    130                 135                 140                 


Ser Pro Arg Ala Pro Phe Tyr Arg Pro Leu Ala Pro Glu Leu Arg Ala 
145                 150                 155                 160 


Arg Gln Leu Glu Leu Gly Ala Glu His Ala Leu Leu Leu Asp Ala Ala 
                165                 170                 175     


Gly Gln Val Phe Ser Trp Gly Gly Gly Arg His Gly Gln Leu Gly His 
            180                 185                 190         


Gly Thr Leu Glu Ala Glu Leu Glu Pro Arg Leu Leu Glu Ala Leu Gln 
        195                 200                 205             


Gly Leu Val Met Ala Glu Val Ala Ala Gly Gly Trp His Ser Val Cys 
    210                 215                 220                 


Val Ser Glu Thr Gly Asp Ile Tyr Ile Trp Gly Trp Asn Glu Ser Gly 
225                 230                 235                 240 


Gln Leu Ala Leu Pro Thr Arg Asn Leu Ala Glu Asp Gly Glu Thr Val 
                245                 250                 255     


Ala Arg Glu Ala Thr Glu Leu Asn Glu Asp Gly Ser Gln Val Lys Arg 
            260                 265                 270         


Thr Gly Gly Ala Glu Asp Gly Ala Pro Ala Pro Phe Ile Ala Val Gln 
        275                 280                 285             


Pro Phe Pro Ala Leu Leu Asp Leu Pro Met Gly Ser Asp Ala Val Lys 
    290                 295                 300                 


Ala Ser Cys Gly Ser Arg His Thr Ala Val Val Thr Arg Thr Gly Glu 
305                 310                 315                 320 


Leu Tyr Thr Trp Gly Trp Gly Lys Tyr Gly Gln Leu Gly His Glu Asp 
                325                 330                 335     


Thr Thr Ser Leu Asp Arg Pro Arg Arg Val Glu Tyr Phe Val Asp Lys 
            340                 345                 350         


Gln Leu Gln Val Lys Ala Val Thr Cys Gly Pro Trp Asn Thr Tyr Val 
        355                 360                 365             


Tyr Ala Val Glu Lys Gly Lys Ser 
    370                 375     


<210>  3354
<211>  2774
<212>  DNA
<213>  Homosapiens

<400>  3354
taaaagctgc ttcctgttgg ggcatgagtc cggcgcgtgt cgggttttga gctgccgcgg     60

tcccgggact gagctccttg ggagcagaca gctgtcctca ctggcagagg aggagcgctc    120

agtaaatgct cgctggacga ataaatggct agataagata aggcagctcc agcccctgga    180

aggccagaga cttgccagtg tcccactagc gggctcttcg caagaatccc cccgggcccg    240

ccgcagccag gcggcggccg gcagagggcg ctgctcgggc atggcggagg agcggccggg    300

ggcctggttc ggcttcggtt tctgcggctt cgggcaggag ctgggctccg gacgcgggcg    360

ccaggtgcac agccccagtc cgctgcgggc gggcgtcgac atctgccgcg tgagcgcgag    420

ctggagctac accgctttcg tgacccgtgg aggccgcttg gagctgtcgg gctcagccag    480

cggcgcggcg ggccgctgca aggacgcgtg ggcctcggag gggctcctcg cggtgctgcg    540

cgccgggccg gggccggagg cgttactgca ggtctgggcg gccgaatcgg cgctgcgtgg    600

ggagccattg tgggcccaga atgtggtgcc cgaggccgaa ggggaagacg atccggccgg    660

tgaggcccag gctgggaggc tacccctgct gccctgcgcc cgtgcctacg tgagcccgcg    720

ggcgcccttc taccggcctc tggctccgga gctgcgggca cgccagctgg agctgggcgc    780

cgagcacgcg ttgctgctgg acgctgctgg ccaggtgttc tcctggggcg ggggcaggca    840

tggacagctg ggccatggga ccctggaggc agagctggag ccacggctgt tggaggcgtt    900

gcagggccta gtcatggctg aggtggccgc ggggggctgg cattctgtgt gtgtgagtga    960

gactggggat atttatatct ggggctggaa tgaatcaggg cagctggccc tgcccaccag   1020

gaacctggca gaggatggag agactgtcgc aagggaagcc acagaactga atgaagatgg   1080

ttctcaggtg aagagaacgg gtggggctga ggatggagcc cctgccccct tcatagctgt   1140

ccagcccttc ccggcattac tggatctccc catgggctca gatgcagtca aggccagctg   1200

tggatcccgg cacacagctg tggtgacacg aacaggggag ctctacacct ggggctgggg   1260

taaatatgga cagctgggcc acgaggacac caccagcttg gatcggcctc gccgtgtgga   1320

atactttgta gataagcaac tccaagtaaa ggctgtcacc tgtgggccgt ggaacaccta   1380

cgtgtatgct gtggagaaag ggaagagctg acatgtgtac gtatatgtat atgcaacacc   1440

tgtgagaccc ccattcaggt caaggaaaac cattgcctgc accccaaggg ccccatattt   1500

gcccctcccc atcacagtcc tgcccttcac cctcaagcac ggtcctaaac ttgtctgcac   1560

tttagaaaca cctggagagc attgaaaact ctgctgccta aggtcagcat caatcaaaac   1620

aatgaaatca atgaaacaat gaaaccagag cttctaggtg tgtggcctgg atagtggtag   1680

attcaaagct ccacccacct catcccaggt acatttgatg tgcagctgag attggggcac   1740

attccaggtc atcgtcttct gtcagtcatt tccctgcttt cgtttgaatt ttaccattct   1800

tgtatgcagc cttatacgac atagttgtgt ttgcttttga gtgttagata aatggaatcc   1860

tgtgtatgtg cttttgtgtc gtttttgtca ctcagcattg tataatccat ccttgttggg   1920

tcctggagtt catttttaat gctatatggt gttctgttgt atgaataata cctcaagtga   1980

tacagccttg ttgatggtca tttttattgt ttctgatttt ggtcattcca cataattctt   2040

tgtgcagtct tctgcacatg tgcacaagtt cctttgcaga acattgagtt gaattgctaa   2100

gtcaggagat acctttaatt ttactagata actgttgccc ccagcagggt ggggtctact   2160

gtggctaaaa tgtcaggtag atgcacactg gttttaattg gcatttccct ggatactgat   2220

gaggttgagt agcttttcat ttgttttgga tggctgggca tggtggctca cacctgtagt   2280

cccagcactt tgggaggcta agcagggaga ttgcttgagg cgaagagttc atatgtttat   2340

tggccacttg gagtttttct gttgtcaagt gcctgttcaa gttttctggc cttttaaaat   2400

gttctgtatt ttccttagtg atttttcttt tggatatttc agatacaagt cttttgagag   2460

ttagtattca gagtatcttc tgctacaatg tagtttgttt cagtctctct tggtattacc   2520

aattttaata cttaggtgat gcttactcca tgccaggtaa ggctcaaagt gctttacaag   2580

tatcaactta ttttgataaa ataagcttat cagtagtttt ctttatagtt aaattctatt   2640

tgtgcatgtg tgtgtctgtg gtttagcaaa tgtttcccac ccatggggtc ttttttattg   2700

tggtaaaata tactgaacat aaaatttatg ttcaataaaa aacaaaaatt gtttttaacc   2760

attttaaaaa aaaa                                                     2774


<210>  3355
<211>  376
<212>  PRT
<213>  Homosapiens

<400>  3355

Met Ala Glu Glu Arg Pro Gly Ala Trp Phe Gly Phe Gly Phe Cys Gly 
1               5                   10                  15      


Phe Gly Gln Glu Leu Gly Ser Gly Arg Gly Arg Gln Val His Ser Pro 
            20                  25                  30          


Ser Pro Leu Arg Ala Gly Val Asp Ile Cys Arg Val Ser Ala Ser Trp 
        35                  40                  45              


Ser Tyr Thr Ala Phe Val Thr Arg Gly Gly Arg Leu Glu Leu Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Ala Ala Gly Arg Cys Lys Asp Ala Trp Ala Ser Glu 
65                  70                  75                  80  


Gly Leu Leu Ala Val Leu Arg Ala Gly Pro Gly Pro Glu Ala Leu Leu 
                85                  90                  95      


Gln Val Trp Ala Ala Glu Ser Ala Leu Arg Gly Glu Pro Leu Trp Ala 
            100                 105                 110         


Gln Asn Val Val Pro Glu Ala Glu Gly Glu Asp Asp Pro Ala Gly Glu 
        115                 120                 125             


Ala Gln Ala Gly Arg Leu Pro Leu Leu Pro Cys Ala Arg Ala Tyr Val 
    130                 135                 140                 


Ser Pro Arg Ala Pro Phe Tyr Arg Pro Leu Ala Pro Glu Leu Arg Ala 
145                 150                 155                 160 


Arg Gln Leu Glu Leu Gly Ala Glu His Ala Leu Leu Leu Asp Ala Ala 
                165                 170                 175     


Gly Gln Val Phe Ser Trp Gly Gly Gly Arg His Gly Gln Leu Gly His 
            180                 185                 190         


Gly Thr Leu Glu Ala Glu Leu Glu Pro Arg Leu Leu Glu Ala Leu Gln 
        195                 200                 205             


Gly Leu Val Met Ala Glu Val Ala Ala Gly Gly Trp His Ser Val Cys 
    210                 215                 220                 


Val Ser Glu Thr Gly Asp Ile Tyr Ile Trp Gly Trp Asn Glu Ser Gly 
225                 230                 235                 240 


Gln Leu Ala Leu Pro Thr Arg Asn Leu Ala Glu Asp Gly Glu Thr Val 
                245                 250                 255     


Ala Arg Glu Ala Thr Glu Leu Asn Glu Asp Gly Ser Gln Val Lys Arg 
            260                 265                 270         


Thr Gly Gly Ala Glu Asp Gly Ala Pro Ala Pro Phe Ile Ala Val Gln 
        275                 280                 285             


Pro Phe Pro Ala Leu Leu Asp Leu Pro Met Gly Ser Asp Ala Val Lys 
    290                 295                 300                 


Ala Ser Cys Gly Ser Arg His Thr Ala Val Val Thr Arg Thr Gly Glu 
305                 310                 315                 320 


Leu Tyr Thr Trp Gly Trp Gly Lys Tyr Gly Gln Leu Gly His Glu Asp 
                325                 330                 335     


Thr Thr Ser Leu Asp Arg Pro Arg Arg Val Glu Tyr Phe Val Asp Lys 
            340                 345                 350         


Gln Leu Gln Val Lys Ala Val Thr Cys Gly Pro Trp Asn Thr Tyr Val 
        355                 360                 365             


Tyr Ala Val Glu Lys Gly Lys Ser 
    370                 375     


<210>  3356
<211>  3128
<212>  DNA
<213>  Homosapiens

<400>  3356
gcttcgcccc gtggcgcggt ttgaaatttt gcggggctca acggctcgcg gagcggctac     60

gcggagtgac atcgccggtg tttgcgggtg gttgttgctc tcggggccgt gtggagtagg    120

tctggacctg gactcacggc tgcttggagc gtccgccatg aggagaagtg aggtgctggc    180

ggaggagtcc atagtatgtc tgcagaaagc cctaaatcac cttcgggaaa tatgggagct    240

aattgggatt ccagaggacc agcggttaca aagaactgag gtggtaaaga agcatatcaa    300

ggaactcctg gatatgatga ttgctgaaga ggaaagcctg aaggaaagac tcatcaaaag    360

catatccgtc tgtcagaaag agctgaacac tctgtgcagc gagttacatg ttgagccatt    420

tcaggaagaa ggagagacga ccatcttgca actagaaaaa gatttgcgca cccaagtgga    480

attgatgcga aaacagaaaa aggagagaaa acaggaactg aagctacttc aagagcaaga    540

tcaagaactg tgcgaaattc tttgtatgcc ccactatgat attgacagtg cctcagtgcc    600

cagcttagaa gagctgaacc agttcaggca acatgtgaca actttgaggg aaacaaaggc    660

ttctaggcgt gaggagtttg tcagtataaa gagacagatc atactgtgta tggaagaatt    720

agaccacacc ccagacacaa gctttgaaag agatgtggtg tgtgaagacg aagatgcctt    780

ttgtttgtct ttggagaata ttgcaacact acaaaagttg ctacggcagc tggaaatgca    840

gaaatcacaa aatgaagcag tgtgtgaggg gctgcgtact caaatccgag agctctggga    900

caggttgcaa atacctgaag aagaaagaga agctgtggcc accattatgt ctgggtcaaa    960

ggccaaggtc cggaaagcgc tgcaattaga agtggatcgg ttggaagaac tgaaaatgca   1020

aaacatgaag aaagtgattg aggcaattcg agtggagctg gttcagtact gggaccagtg   1080

cttttatagc caggagcaga gacaagcttt tgcccctttc tgtgctgagg actacacaga   1140

aagtctgctc cagctccacg atgctgagat tgtgcggtta aaaaactact atgaagttca   1200

caaggaactc tttgaaggtg tccagaagtg ggaagaaacc tggaggcttt tcttagagtt   1260

tgagagaaaa gcttcagatc caaatcgatt tacaaaccga ggaggaaatc ttctaaaaga   1320

agaaaaacaa cgagccaagc tccagaaaat gctgcccaag ctggaagaag agttgaaggc   1380

acgaattgaa ttgtgggaac aggaacattc aaaggcattt atggtgaatg ggcagaaatt   1440

catggagtat gtggcagaac aatgggagat gcatcgattg gagaaagaga gagccaagca   1500

ggaaagacaa ctgaagaaca aaaaacagac agagacagag atgctgtatg gcagcgctcc   1560

tcgaacacct agcaagcggc gaggactggc tcccaataca ccgggcaaag cacgtaagct   1620

gaacactacc accatgtcca atgctacggc caatagtagc attcggccta tctttggagg   1680

gacagtctac cactcccccg tgtctcgact tcctccttct ggcagcaagc cagtcgctgc   1740

ttccacctgt tcagggaaga aaacaccccg tactggcagg catggagcca acaaggagaa   1800

cctggagctc aacggcagca tcctgagtgg tgggtaccct ggctcggccc ccctccagcg   1860

caacttcagc attaattctg ttgccagcac ctattctgag tttgcgaagg atccgtccct   1920

ctctgacagt tccactgttg ggcttcagcg agaactttca aaggcttcca aatctgatgc   1980

tacttctgga atcctcaatt caaccaacat ccagtcctga gaagccctga tcagtcaacc   2040

agctgtggct tcctgtgcct agactggacc taattatatg ggggtgactt tagtttttct   2100

tcagcttagg cgtgcttgaa accttggcca ggttccatga ccatgggcct aacttaaaga   2160

tgtgaatgag tgttacagtt gaaagcccat cataggttta gtggtcctag gagacttggt   2220

tttgacttat atacatgaaa agtttatggc aagaagtgca aattttagca tatggggcct   2280

gacttctcta ccacataatt ctacttgctg aagcatgatc aaagcttgtt ttatttcacc   2340

actgtaggaa aatgattgac tatgcccatc cctgggggta attttggcat gtatacctgt   2400

aactagtaat taacatcttt tttgtttagg catgttcaat taatgctgta gctatcatag   2460

ctttgctctt acctgaagcc ttgtccccac cacacaggac agccttcctc ctgaagagaa   2520

tgtctttgtg tgtccgaagt tgagatggcc tgccctactg ccaaagaggt gacaggaagg   2580

ctgggagcag ctttgttaaa ttgtgttcag ttctgttaca cagtgcattg ccctttgttg   2640

ggggtatgca tgtatgaaca cacatgcttg tcggaacgct ttctcggcgt ttgtcccttg   2700

gctctcatct cccccattcc tgtgcctact ttgcctgagt tcttctaccc ccgcagttgc   2760

cagccacatt gggagtctgt ttgttccaat gggttgagct gtctttgtcg tggagatctg   2820

gaactttgca catgtcacta ctggggaggt gttcctgctc tagcttccac gatgaggcgc   2880

cctctttacc tatcctctca atcactactc ttcttgaagc actattattt attcttccgc   2940

tgtctgcctg cagcagtact actgtcaaca tagtgtaaat ggttctcaaa agcttaccag   3000

tgtggacttg gtgttagcca cgctgtttac tcatacagta cgtgtcctgt ttttaaaata   3060

tacaattatt cttaaaaata aattaaaatc tgtatactta catttcaaaa agaaaaaaaa   3120

aaaaaaaa                                                            3128


<210>  3357
<211>  620
<212>  PRT
<213>  Homosapiens

<400>  3357

Met Arg Arg Ser Glu Val Leu Ala Glu Glu Ser Ile Val Cys Leu Gln 
1               5                   10                  15      


Lys Ala Leu Asn His Leu Arg Glu Ile Trp Glu Leu Ile Gly Ile Pro 
            20                  25                  30          


Glu Asp Gln Arg Leu Gln Arg Thr Glu Val Val Lys Lys His Ile Lys 
        35                  40                  45              


Glu Leu Leu Asp Met Met Ile Ala Glu Glu Glu Ser Leu Lys Glu Arg 
    50                  55                  60                  


Leu Ile Lys Ser Ile Ser Val Cys Gln Lys Glu Leu Asn Thr Leu Cys 
65                  70                  75                  80  


Ser Glu Leu His Val Glu Pro Phe Gln Glu Glu Gly Glu Thr Thr Ile 
                85                  90                  95      


Leu Gln Leu Glu Lys Asp Leu Arg Thr Gln Val Glu Leu Met Arg Lys 
            100                 105                 110         


Gln Lys Lys Glu Arg Lys Gln Glu Leu Lys Leu Leu Gln Glu Gln Asp 
        115                 120                 125             


Gln Glu Leu Cys Glu Ile Leu Cys Met Pro His Tyr Asp Ile Asp Ser 
    130                 135                 140                 


Ala Ser Val Pro Ser Leu Glu Glu Leu Asn Gln Phe Arg Gln His Val 
145                 150                 155                 160 


Thr Thr Leu Arg Glu Thr Lys Ala Ser Arg Arg Glu Glu Phe Val Ser 
                165                 170                 175     


Ile Lys Arg Gln Ile Ile Leu Cys Met Glu Glu Leu Asp His Thr Pro 
            180                 185                 190         


Asp Thr Ser Phe Glu Arg Asp Val Val Cys Glu Asp Glu Asp Ala Phe 
        195                 200                 205             


Cys Leu Ser Leu Glu Asn Ile Ala Thr Leu Gln Lys Leu Leu Arg Gln 
    210                 215                 220                 


Leu Glu Met Gln Lys Ser Gln Asn Glu Ala Val Cys Glu Gly Leu Arg 
225                 230                 235                 240 


Thr Gln Ile Arg Glu Leu Trp Asp Arg Leu Gln Ile Pro Glu Glu Glu 
                245                 250                 255     


Arg Glu Ala Val Ala Thr Ile Met Ser Gly Ser Lys Ala Lys Val Arg 
            260                 265                 270         


Lys Ala Leu Gln Leu Glu Val Asp Arg Leu Glu Glu Leu Lys Met Gln 
        275                 280                 285             


Asn Met Lys Lys Val Ile Glu Ala Ile Arg Val Glu Leu Val Gln Tyr 
    290                 295                 300                 


Trp Asp Gln Cys Phe Tyr Ser Gln Glu Gln Arg Gln Ala Phe Ala Pro 
305                 310                 315                 320 


Phe Cys Ala Glu Asp Tyr Thr Glu Ser Leu Leu Gln Leu His Asp Ala 
                325                 330                 335     


Glu Ile Val Arg Leu Lys Asn Tyr Tyr Glu Val His Lys Glu Leu Phe 
            340                 345                 350         


Glu Gly Val Gln Lys Trp Glu Glu Thr Trp Arg Leu Phe Leu Glu Phe 
        355                 360                 365             


Glu Arg Lys Ala Ser Asp Pro Asn Arg Phe Thr Asn Arg Gly Gly Asn 
    370                 375                 380                 


Leu Leu Lys Glu Glu Lys Gln Arg Ala Lys Leu Gln Lys Met Leu Pro 
385                 390                 395                 400 


Lys Leu Glu Glu Glu Leu Lys Ala Arg Ile Glu Leu Trp Glu Gln Glu 
                405                 410                 415     


His Ser Lys Ala Phe Met Val Asn Gly Gln Lys Phe Met Glu Tyr Val 
            420                 425                 430         


Ala Glu Gln Trp Glu Met His Arg Leu Glu Lys Glu Arg Ala Lys Gln 
        435                 440                 445             


Glu Arg Gln Leu Lys Asn Lys Lys Gln Thr Glu Thr Glu Met Leu Tyr 
    450                 455                 460                 


Gly Ser Ala Pro Arg Thr Pro Ser Lys Arg Arg Gly Leu Ala Pro Asn 
465                 470                 475                 480 


Thr Pro Gly Lys Ala Arg Lys Leu Asn Thr Thr Thr Met Ser Asn Ala 
                485                 490                 495     


Thr Ala Asn Ser Ser Ile Arg Pro Ile Phe Gly Gly Thr Val Tyr His 
            500                 505                 510         


Ser Pro Val Ser Arg Leu Pro Pro Ser Gly Ser Lys Pro Val Ala Ala 
        515                 520                 525             


Ser Thr Cys Ser Gly Lys Lys Thr Pro Arg Thr Gly Arg His Gly Ala 
    530                 535                 540                 


Asn Lys Glu Asn Leu Glu Leu Asn Gly Ser Ile Leu Ser Gly Gly Tyr 
545                 550                 555                 560 


Pro Gly Ser Ala Pro Leu Gln Arg Asn Phe Ser Ile Asn Ser Val Ala 
                565                 570                 575     


Ser Thr Tyr Ser Glu Phe Ala Lys Asp Pro Ser Leu Ser Asp Ser Ser 
            580                 585                 590         


Thr Val Gly Leu Gln Arg Glu Leu Ser Lys Ala Ser Lys Ser Asp Ala 
        595                 600                 605             


Thr Ser Gly Ile Leu Asn Ser Thr Asn Ile Gln Ser 
    610                 615                 620 


<210>  3358
<211>  3091
<212>  DNA
<213>  Homosapiens

<400>  3358
gcttcgcccc gtggcgcggt ttgaaatttt gcggggctca acggctcgcg gagcggctac     60

gcggagtgac atcgccggtg tttgcgggtg gttgttgctc tcggggccgt gtggagtagg    120

tctggacctg gactcacggc tgcttggagc gtccgccatg aggagaagtg aggtgctggc    180

ggaggagtcc atagtatgtc tgcagaaagc cctaaatcac cttcgggaaa tatgggagct    240

aattgggatt ccagaggacc agcggttaca aagaactgag gtggtaaaga agcatatcaa    300

ggaactcctg gatatgatga ttgctgaaga ggaaagcctg aaggaaagac tcatcaaaag    360

catatccgtc tgtcagaaag agctgaacac tctgtgcagc gagttacatg ttgagccatt    420

tcaggaagaa ggagagacga ccatcttgca actagaaaaa gatttgcgca cccaagtgga    480

attgatgcga aaacagaaaa aggagagaaa acaggaactg aagctacttc aagagcaaga    540

tcaagaactg tgcgaaattc tttgtatgcc ccactatgat attgacagtg cctcagtgcc    600

cagcttagaa gagctgaacc agttcaggca acatgtgaca actttgaggg aaacaaaggc    660

ttctaggcgt gaggagtttg tcagtataaa gagacagatc atactgtgta tggaagaatt    720

agaccacacc ccagacacaa gctttgaaag agatgtggtg tgtgaagacg aagatgcctt    780

ttgtttgtct ttggagaata ttgcaacact acaaaagttg ctacggcagc tggaaatgca    840

gaaatcacaa aatgaagcag tgtgtgaggg gctgcgtact caaatccgag agctctggga    900

caggttgcaa atacctgaag aagaaagaga agctgtggcc accattatgt ctgggtcaaa    960

ggccaaggtc cggaaagcgc tgcaattaga agtggatcgg ttggaagaac tgaaaatgca   1020

aaacatgaag aaagtgattg aggcaattcg agtggagctg gttcagtact gggaccagtg   1080

cttttatagc caggagcaga gacaagcttt tgcccctttc tgtgctgagg actacacaga   1140

aagtctgctc cagctccacg atgctgagat tgtgcggtta aaaaactact atgaagttca   1200

caaggaactc tttgaaggtg tccagaagtg ggaagaaacc tggaggcttt tcttagagtt   1260

tgagagaaaa gcttcagatc caaatcgatt tacaaaccga ggaggaaatc ttctaaaaga   1320

agaaaaacaa cgagccaagc tccagaaaat gctgcccaag ctggaagaag agttgaaggc   1380

acgaattgaa ttgtgggaac aggaacattc aaaggcattt atggtgaatg ggcagaaatt   1440

catggagtat gtggcagaac aatgggagat gcatcgattg gagaaagaga gagccaagca   1500

ggaaagacaa ctgaagaaca aaaaacagac agagacagag atgctgtatg gcagcgctcc   1560

tcgaacacct agcaagcggc gaggactggc tcccaataca ccgggcaaag cacgtaagct   1620

gaacactacc accatgtcca atgctacggc caatagtagc attcggccta tctttggagg   1680

gacagtctac cactcccccg tgtctcgact tcctccttct ggcagcaagc cagtcgctgc   1740

ttccacctgt tcagggaaga aaacaccccg tactggcagg catggagcca acaaggagaa   1800

cctggagctc aacggcagca tcctgagtgg tgggtaccct ggctcggccc ccctccagcg   1860

caacttcagc attaattctg ttgccagcac ctattctgag tttgcgcgag aactttcaaa   1920

ggcttccaaa tctgatgcta cttctggaat cctcaattca accaacatcc agtcctgaga   1980

agccctgatc agtcaaccag ctgtggcttc ctgtgcctag actggaccta attatatggg   2040

ggtgacttta gtttttcttc agcttaggcg tgcttgaaac cttggccagg ttccatgacc   2100

atgggcctaa cttaaagatg tgaatgagtg ttacagttga aagcccatca taggtttagt   2160

ggtcctagga gacttggttt tgacttatat acatgaaaag tttatggcaa gaagtgcaaa   2220

ttttagcata tggggcctga cttctctacc acataattct acttgctgaa gcatgatcaa   2280

agcttgtttt atttcaccac tgtaggaaaa tgattgacta tgcccatccc tgggggtaat   2340

tttggcatgt atacctgtaa ctagtaatta acatcttttt tgtttaggca tgttcaatta   2400

atgctgtagc tatcatagct ttgctcttac ctgaagcctt gtccccacca cacaggacag   2460

ccttcctcct gaagagaatg tctttgtgtg tccgaagttg agatggcctg ccctactgcc   2520

aaagaggtga caggaaggct gggagcagct ttgttaaatt gtgttcagtt ctgttacaca   2580

gtgcattgcc ctttgttggg ggtatgcatg tatgaacaca catgcttgtc ggaacgcttt   2640

ctcggcgttt gtcccttggc tctcatctcc cccattcctg tgcctacttt gcctgagttc   2700

ttctaccccc gcagttgcca gccacattgg gagtctgttt gttccaatgg gttgagctgt   2760

ctttgtcgtg gagatctgga actttgcaca tgtcactact ggggaggtgt tcctgctcta   2820

gcttccacga tgaggcgccc tctttaccta tcctctcaat cactactctt cttgaagcac   2880

tattatttat tcttccgctg tctgcctgca gcagtactac tgtcaacata gtgtaaatgg   2940

ttctcaaaag cttaccagtg tggacttggt gttagccacg ctgtttactc atacagtacg   3000

tgtcctgttt ttaaaatata caattattct taaaaataaa ttaaaatctg tatacttaca   3060

tttcaaaaag aaaaaaaaaa aaaaaaaaaa a                                  3091


<210>  3359
<211>  606
<212>  PRT
<213>  Homosapiens

<400>  3359

Met Arg Arg Ser Glu Val Leu Ala Glu Glu Ser Ile Val Cys Leu Gln 
1               5                   10                  15      


Lys Ala Leu Asn His Leu Arg Glu Ile Trp Glu Leu Ile Gly Ile Pro 
            20                  25                  30          


Glu Asp Gln Arg Leu Gln Arg Thr Glu Val Val Lys Lys His Ile Lys 
        35                  40                  45              


Glu Leu Leu Asp Met Met Ile Ala Glu Glu Glu Ser Leu Lys Glu Arg 
    50                  55                  60                  


Leu Ile Lys Ser Ile Ser Val Cys Gln Lys Glu Leu Asn Thr Leu Cys 
65                  70                  75                  80  


Ser Glu Leu His Val Glu Pro Phe Gln Glu Glu Gly Glu Thr Thr Ile 
                85                  90                  95      


Leu Gln Leu Glu Lys Asp Leu Arg Thr Gln Val Glu Leu Met Arg Lys 
            100                 105                 110         


Gln Lys Lys Glu Arg Lys Gln Glu Leu Lys Leu Leu Gln Glu Gln Asp 
        115                 120                 125             


Gln Glu Leu Cys Glu Ile Leu Cys Met Pro His Tyr Asp Ile Asp Ser 
    130                 135                 140                 


Ala Ser Val Pro Ser Leu Glu Glu Leu Asn Gln Phe Arg Gln His Val 
145                 150                 155                 160 


Thr Thr Leu Arg Glu Thr Lys Ala Ser Arg Arg Glu Glu Phe Val Ser 
                165                 170                 175     


Ile Lys Arg Gln Ile Ile Leu Cys Met Glu Glu Leu Asp His Thr Pro 
            180                 185                 190         


Asp Thr Ser Phe Glu Arg Asp Val Val Cys Glu Asp Glu Asp Ala Phe 
        195                 200                 205             


Cys Leu Ser Leu Glu Asn Ile Ala Thr Leu Gln Lys Leu Leu Arg Gln 
    210                 215                 220                 


Leu Glu Met Gln Lys Ser Gln Asn Glu Ala Val Cys Glu Gly Leu Arg 
225                 230                 235                 240 


Thr Gln Ile Arg Glu Leu Trp Asp Arg Leu Gln Ile Pro Glu Glu Glu 
                245                 250                 255     


Arg Glu Ala Val Ala Thr Ile Met Ser Gly Ser Lys Ala Lys Val Arg 
            260                 265                 270         


Lys Ala Leu Gln Leu Glu Val Asp Arg Leu Glu Glu Leu Lys Met Gln 
        275                 280                 285             


Asn Met Lys Lys Val Ile Glu Ala Ile Arg Val Glu Leu Val Gln Tyr 
    290                 295                 300                 


Trp Asp Gln Cys Phe Tyr Ser Gln Glu Gln Arg Gln Ala Phe Ala Pro 
305                 310                 315                 320 


Phe Cys Ala Glu Asp Tyr Thr Glu Ser Leu Leu Gln Leu His Asp Ala 
                325                 330                 335     


Glu Ile Val Arg Leu Lys Asn Tyr Tyr Glu Val His Lys Glu Leu Phe 
            340                 345                 350         


Glu Gly Val Gln Lys Trp Glu Glu Thr Trp Arg Leu Phe Leu Glu Phe 
        355                 360                 365             


Glu Arg Lys Ala Ser Asp Pro Asn Arg Phe Thr Asn Arg Gly Gly Asn 
    370                 375                 380                 


Leu Leu Lys Glu Glu Lys Gln Arg Ala Lys Leu Gln Lys Met Leu Pro 
385                 390                 395                 400 


Lys Leu Glu Glu Glu Leu Lys Ala Arg Ile Glu Leu Trp Glu Gln Glu 
                405                 410                 415     


His Ser Lys Ala Phe Met Val Asn Gly Gln Lys Phe Met Glu Tyr Val 
            420                 425                 430         


Ala Glu Gln Trp Glu Met His Arg Leu Glu Lys Glu Arg Ala Lys Gln 
        435                 440                 445             


Glu Arg Gln Leu Lys Asn Lys Lys Gln Thr Glu Thr Glu Met Leu Tyr 
    450                 455                 460                 


Gly Ser Ala Pro Arg Thr Pro Ser Lys Arg Arg Gly Leu Ala Pro Asn 
465                 470                 475                 480 


Thr Pro Gly Lys Ala Arg Lys Leu Asn Thr Thr Thr Met Ser Asn Ala 
                485                 490                 495     


Thr Ala Asn Ser Ser Ile Arg Pro Ile Phe Gly Gly Thr Val Tyr His 
            500                 505                 510         


Ser Pro Val Ser Arg Leu Pro Pro Ser Gly Ser Lys Pro Val Ala Ala 
        515                 520                 525             


Ser Thr Cys Ser Gly Lys Lys Thr Pro Arg Thr Gly Arg His Gly Ala 
    530                 535                 540                 


Asn Lys Glu Asn Leu Glu Leu Asn Gly Ser Ile Leu Ser Gly Gly Tyr 
545                 550                 555                 560 


Pro Gly Ser Ala Pro Leu Gln Arg Asn Phe Ser Ile Asn Ser Val Ala 
                565                 570                 575     


Ser Thr Tyr Ser Glu Phe Ala Arg Glu Leu Ser Lys Ala Ser Lys Ser 
            580                 585                 590         


Asp Ala Thr Ser Gly Ile Leu Asn Ser Thr Asn Ile Gln Ser 
        595                 600                 605     


<210>  3360
<211>  3011
<212>  DNA
<213>  Homosapiens

<400>  3360
gcttcgcccc gtggcgcggt ttgaaatttt gcggggctca acggctcgcg gagcggctac     60

gcggagtgac atcgccggtg tttgcgggtg gttgttgctc tcggggccgt gtggagtagg    120

tctggacctg gactcacggc tgcttggagc gtccgccatg aggagaagtg aggtgctggc    180

ggaggagtcc atagtatgtc tgcagaaagc cctaaatcac cttcgggaaa tatgggagct    240

aattgggatt ccagaggacc agcggttaca aagaactgag gtggtaaaga agcatatcaa    300

ggaactcctg gatatgatga ttgctgaaga ggaaagcctg aaggaaagac tcatcaaaag    360

catatccgtc tgtcagaaag agctgaacac tctgtgcagc gagttacatg ttgagccatt    420

tcaggaagaa ggagagacga ccatcttgca actagaaaaa gatttgcgca cccaagtgga    480

attgatgcga aaacagaaaa aggagagaaa acaggaactg aagctacttc aagagcaaga    540

tcaagaactg tgcgaaattc tttgtatgcc ccactatgat attgacagtg cctcagtgcc    600

cagcttagaa gagctgaacc agttcaggca acatgtgaca actttgaggg aaacaaaggc    660

ttctaggcgt gaggagtttg tcagtataaa gagacagatc atactgtgta tggaagaatt    720

agaccacacc ccagacacaa gctttgaaag agatgtggtg tgtgaagacg aagatgcctt    780

ttgtttgtct ttggagaata ttgcaacact acaaaagttg ctacggcagc tggaaatgca    840

gaaatcacaa aatgaagcag tgtgtgaggg gctgcgtact caaatccgag agctctggga    900

caggttgcaa atacctgaag aagaaagaga agctgtggcc accattatgt ctgggtcaaa    960

ggccaaggtc cggaaagcgc tgcaattaga agtggatcgg ttggaagaac tgaaaatgca   1020

aaacatgaag aaagtgattg aggcaattcg agtggagctg gttcagtact gggaccagtg   1080

cttttatagc caggagcaga gacaagcttt tgcccctttc tgtgctgagg actacacaga   1140

aagtctgctc cagctccacg atgctgagat tgtgcggtta aaaaactact atgaagttca   1200

caaggaactc tttgaaggtg tccagaagtg ggaagaaacc tggaggcttt tcttagagtt   1260

tgagagaaaa gcttcagatc caaatcgatt tacaaaccga ggaggaaatc ttctaaaaga   1320

agaaaaacaa cgagccaagc tccagaaaat gctgcccaag ctggaagaag agttgaaggc   1380

acgaattgaa ttgtgggaac aggaacattc aaaggcattt atggtgaatg ggcagaaatt   1440

catggagtat gtggcagaac aatgggagat gcatcgattg gagaaagaga gagccaagca   1500

ggaaagacaa ctgaagaaca aaaaacagac agagacagag atgctgtatg gcagcgctcc   1560

tcgaacacct agcaagcggc gaggactggc tcccaataca ccgggcaaag cacgtaagct   1620

gaacactacc accatgtcca atgctacggc caatagtagc attcggccta tctttggagg   1680

gacagtctac cactcccccg tgtctcgact tcctccttct ggcagcaagc cagtcgctgc   1740

ttccacctgt tcagggaaga aaacaccccg tactggcagg catggagcca acaaggagaa   1800

cctggagctc aacggcagca tcctgagtgc gagaactttc aaaggcttcc aaatctgatg   1860

ctacttctgg aatcctcaat tcaaccaaca tccagtcctg agaagccctg atcagtcaac   1920

cagctgtggc ttcctgtgcc tagactggac ctaattatat gggggtgact ttagtttttc   1980

ttcagcttag gcgtgcttga aaccttggcc aggttccatg accatgggcc taacttaaag   2040

atgtgaatga gtgttacagt tgaaagccca tcataggttt agtggtccta ggagacttgg   2100

ttttgactta tatacatgaa aagtttatgg caagaagtgc aaattttagc atatggggcc   2160

tgacttctct accacataat tctacttgct gaagcatgat caaagcttgt tttatttcac   2220

cactgtagga aaatgattga ctatgcccat ccctgggggt aattttggca tgtatacctg   2280

taactagtaa ttaacatctt ttttgtttag gcatgttcaa ttaatgctgt agctatcata   2340

gctttgctct tacctgaagc cttgtcccca ccacacagga cagccttcct cctgaagaga   2400

atgtctttgt gtgtccgaag ttgagatggc ctgccctact gccaaagagg tgacaggaag   2460

gctgggagca gctttgttaa attgtgttca gttctgttac acagtgcatt gccctttgtt   2520

gggggtatgc atgtatgaac acacatgctt gtcggaacgc tttctcggcg tttgtccctt   2580

ggctctcatc tcccccattc ctgtgcctac tttgcctgag ttcttctacc cccgcagttg   2640

ccagccacat tgggagtctg tttgttccaa tgggttgagc tgtctttgtc gtggagatct   2700

ggaactttgc acatgtcact actggggagg tgttcctgct ctagcttcca cgatgaggcg   2760

ccctctttac ctatcctctc aatcactact cttcttgaag cactattatt tattcttccg   2820

ctgtctgcct gcagcagtac tactgtcaac atagtgtaaa tggttctcaa aagcttacca   2880

gtgtggactt ggtgttagcc acgctgttta ctcatacagt acgtgtcctg tttttaaaat   2940

atacaattat tcttaaaaat aaattaaaat ctgtatactt acatttcaaa aagaaaaaaa   3000

aaaaaaaaaa a                                                        3011


<210>  3361
<211>  566
<212>  PRT
<213>  Homosapiens

<400>  3361

Met Arg Arg Ser Glu Val Leu Ala Glu Glu Ser Ile Val Cys Leu Gln 
1               5                   10                  15      


Lys Ala Leu Asn His Leu Arg Glu Ile Trp Glu Leu Ile Gly Ile Pro 
            20                  25                  30          


Glu Asp Gln Arg Leu Gln Arg Thr Glu Val Val Lys Lys His Ile Lys 
        35                  40                  45              


Glu Leu Leu Asp Met Met Ile Ala Glu Glu Glu Ser Leu Lys Glu Arg 
    50                  55                  60                  


Leu Ile Lys Ser Ile Ser Val Cys Gln Lys Glu Leu Asn Thr Leu Cys 
65                  70                  75                  80  


Ser Glu Leu His Val Glu Pro Phe Gln Glu Glu Gly Glu Thr Thr Ile 
                85                  90                  95      


Leu Gln Leu Glu Lys Asp Leu Arg Thr Gln Val Glu Leu Met Arg Lys 
            100                 105                 110         


Gln Lys Lys Glu Arg Lys Gln Glu Leu Lys Leu Leu Gln Glu Gln Asp 
        115                 120                 125             


Gln Glu Leu Cys Glu Ile Leu Cys Met Pro His Tyr Asp Ile Asp Ser 
    130                 135                 140                 


Ala Ser Val Pro Ser Leu Glu Glu Leu Asn Gln Phe Arg Gln His Val 
145                 150                 155                 160 


Thr Thr Leu Arg Glu Thr Lys Ala Ser Arg Arg Glu Glu Phe Val Ser 
                165                 170                 175     


Ile Lys Arg Gln Ile Ile Leu Cys Met Glu Glu Leu Asp His Thr Pro 
            180                 185                 190         


Asp Thr Ser Phe Glu Arg Asp Val Val Cys Glu Asp Glu Asp Ala Phe 
        195                 200                 205             


Cys Leu Ser Leu Glu Asn Ile Ala Thr Leu Gln Lys Leu Leu Arg Gln 
    210                 215                 220                 


Leu Glu Met Gln Lys Ser Gln Asn Glu Ala Val Cys Glu Gly Leu Arg 
225                 230                 235                 240 


Thr Gln Ile Arg Glu Leu Trp Asp Arg Leu Gln Ile Pro Glu Glu Glu 
                245                 250                 255     


Arg Glu Ala Val Ala Thr Ile Met Ser Gly Ser Lys Ala Lys Val Arg 
            260                 265                 270         


Lys Ala Leu Gln Leu Glu Val Asp Arg Leu Glu Glu Leu Lys Met Gln 
        275                 280                 285             


Asn Met Lys Lys Val Ile Glu Ala Ile Arg Val Glu Leu Val Gln Tyr 
    290                 295                 300                 


Trp Asp Gln Cys Phe Tyr Ser Gln Glu Gln Arg Gln Ala Phe Ala Pro 
305                 310                 315                 320 


Phe Cys Ala Glu Asp Tyr Thr Glu Ser Leu Leu Gln Leu His Asp Ala 
                325                 330                 335     


Glu Ile Val Arg Leu Lys Asn Tyr Tyr Glu Val His Lys Glu Leu Phe 
            340                 345                 350         


Glu Gly Val Gln Lys Trp Glu Glu Thr Trp Arg Leu Phe Leu Glu Phe 
        355                 360                 365             


Glu Arg Lys Ala Ser Asp Pro Asn Arg Phe Thr Asn Arg Gly Gly Asn 
    370                 375                 380                 


Leu Leu Lys Glu Glu Lys Gln Arg Ala Lys Leu Gln Lys Met Leu Pro 
385                 390                 395                 400 


Lys Leu Glu Glu Glu Leu Lys Ala Arg Ile Glu Leu Trp Glu Gln Glu 
                405                 410                 415     


His Ser Lys Ala Phe Met Val Asn Gly Gln Lys Phe Met Glu Tyr Val 
            420                 425                 430         


Ala Glu Gln Trp Glu Met His Arg Leu Glu Lys Glu Arg Ala Lys Gln 
        435                 440                 445             


Glu Arg Gln Leu Lys Asn Lys Lys Gln Thr Glu Thr Glu Met Leu Tyr 
    450                 455                 460                 


Gly Ser Ala Pro Arg Thr Pro Ser Lys Arg Arg Gly Leu Ala Pro Asn 
465                 470                 475                 480 


Thr Pro Gly Lys Ala Arg Lys Leu Asn Thr Thr Thr Met Ser Asn Ala 
                485                 490                 495     


Thr Ala Asn Ser Ser Ile Arg Pro Ile Phe Gly Gly Thr Val Tyr His 
            500                 505                 510         


Ser Pro Val Ser Arg Leu Pro Pro Ser Gly Ser Lys Pro Val Ala Ala 
        515                 520                 525             


Ser Thr Cys Ser Gly Lys Lys Thr Pro Arg Thr Gly Arg His Gly Ala 
    530                 535                 540                 


Asn Lys Glu Asn Leu Glu Leu Asn Gly Ser Ile Leu Ser Ala Arg Thr 
545                 550                 555                 560 


Phe Lys Gly Phe Gln Ile 
                565     


<210>  3362
<211>  2509
<212>  DNA
<213>  Homosapiens

<400>  3362
tttttctggt agaaggcggg gttctcctcg tacgctgcgg agtctctgcg gggtgtagac     60

cggaatcctg ctgacgggca gagtggatca gggagggagg gtcgagacac ggtggctgca    120

ggtctgagac aaggctgctc cgaggtagta gctctcttgc ctggaggtgg ccattcattc    180

ctggagtgct gctgaggagc gagggcccat ctggggtctc tggaagtcgg tgcccaggcc    240

tgaaggatag ccccccttgc gcttccctgg gctgcggccg gccttctcag aacgaagggc    300

gtccttccac cccgcggcgc aggtgaccgc tgccatggct tttccccatc ggccggacgc    360

ccctgagctg cctgacttct ccatgctgaa gaggctggct cgagaccagc tcatctatct    420

gctggagcag cttcctggaa aaaaggattt attcattgag gcagatctca tgagcccttt    480

ggatcgaatt gccaatgtct ccatcctgaa gcaacacgaa gtagacaagc tatacaaggt    540

ggagaacaag ccagccctca gctccaatga acaattgtgc ttcttggtca gaccccgcat    600

caagaatatg cgatacattg ccagtcttgt caatgctgac aaattggctg gccgaactcg    660

caaatacaaa gtgatcttca gccctcaaaa gttctatgcg tgtgagatgg tgcttgagga    720

agagggaatc tatggagatg tgagctgtga tgaatgggcc ttctctttgc tgcctcttga    780

tgtggatctg ctgagcatgg aactaccaga atttttcagg gattactttc tggaaggaga    840

tcagcgttgg atcaacactg tagctcaggc cttacacctt ctcagcactc tctatggacc    900

ctttccaaac tgctatggaa ttggcaggtg cgccaagatg gcatatgaat tgtggaggaa    960

cctggaggag gaggaggatg gcgaaaccaa gggccgaagg ccagagattg gacatatctt   1020

tctcttggac agagatgtgg actttgtgac agcactttgc tcccaagtgg tttatgaggg   1080

cctagtagat gacaccttcc gcatcaagtg tgggagtgtc gactttggcc cagaagtcac   1140

atcctctgac aagagcctga aggtgctact caatgccgag gacaaggtgt ttaatgagat   1200

tcggaacgag cacttctcca atgtctttgg cttcttgagc cagaaggccc ggaacttgca   1260

ggcccagtat gatcgccgga gaggcatgga cattaagcag atgaagaatt tcgtgtccca   1320

ggagctcaag ggcctgaaac aggagcaccg cctgctgagt ctccatattg gggcctgtga   1380

atccatcatg aagaagaaaa ccaagcagga tttccaggag ctaatcaaga ctgagcatgc   1440

actgctagag gggttcaaca tccgggagag caccagctac attgaggaac acatagaccg   1500

gcaggtgtcg cctatagaaa gcctgcgcct catgtgcctt ttgtccatca ctgagaatgg   1560

tttgatcccc aaggattacc gatctctgaa aacacagtat ctgcagagct atggccctga   1620

gcacctgcta accttctcca atctgcgaag agctgggctc ctaacggagc aggcccccgg   1680

ggacaccctc acagccgtgg agagtaaagt gagcaagctg gtgaccgaca aggctgcagg   1740

aaagattact gatgccttca gttctctggc caagaggagc aattttcgtg ccatcagcaa   1800

aaagctgaat ttgatcccac gtgtggacgg cgagtatgat ctgaaagtgc cccgagacat   1860

ggcttacgtc ttcagtggtg cttatgtgcc cctgagctgc cgaatcattg agcaggtgct   1920

agagcggcga agctggcagg gccttgatga ggtggtacgg ctgctcaact gcagtgactt   1980

tgcattcaca gatatgacta aggaagacaa ggcttccagt gagtccctgc gcctcatctt   2040

ggtggtgttc ttgggtggtt gtacattctc tgagatctca gccctccggt tcctgggcag   2100

agagaaaggc tacaggttca ttttcctgac gacagcagtc acaaacagcg ctcgccttat   2160

ggaggccatg agtgaggtga aagcctgatg tttttcccgg ccagtgttga catcttccct   2220

gaacacattc ctcagtgaga tgcaggcatc tggcacccag ctgctataac caagtgtcca   2280

ccaactacct gctaagagcc gggagcatgg aacgtgttgg gatttagaga acattatctg   2340

agaaaagagt tcacttcctg ctcccaggat atttctcttt tctgtttatg aagtacaacc   2400

catgctgcta agatgcgagc aggaagaggc atcctttgct aaatcctgtt tgaatgtcat   2460

tgtaaataaa gcctctgctc tcagatgtaa aaaaaaaaaa aaaaaaaaa               2509


<210>  3363
<211>  617
<212>  PRT
<213>  Homosapiens

<400>  3363

Met Ala Phe Pro His Arg Pro Asp Ala Pro Glu Leu Pro Asp Phe Ser 
1               5                   10                  15      


Met Leu Lys Arg Leu Ala Arg Asp Gln Leu Ile Tyr Leu Leu Glu Gln 
            20                  25                  30          


Leu Pro Gly Lys Lys Asp Leu Phe Ile Glu Ala Asp Leu Met Ser Pro 
        35                  40                  45              


Leu Asp Arg Ile Ala Asn Val Ser Ile Leu Lys Gln His Glu Val Asp 
    50                  55                  60                  


Lys Leu Tyr Lys Val Glu Asn Lys Pro Ala Leu Ser Ser Asn Glu Gln 
65                  70                  75                  80  


Leu Cys Phe Leu Val Arg Pro Arg Ile Lys Asn Met Arg Tyr Ile Ala 
                85                  90                  95      


Ser Leu Val Asn Ala Asp Lys Leu Ala Gly Arg Thr Arg Lys Tyr Lys 
            100                 105                 110         


Val Ile Phe Ser Pro Gln Lys Phe Tyr Ala Cys Glu Met Val Leu Glu 
        115                 120                 125             


Glu Glu Gly Ile Tyr Gly Asp Val Ser Cys Asp Glu Trp Ala Phe Ser 
    130                 135                 140                 


Leu Leu Pro Leu Asp Val Asp Leu Leu Ser Met Glu Leu Pro Glu Phe 
145                 150                 155                 160 


Phe Arg Asp Tyr Phe Leu Glu Gly Asp Gln Arg Trp Ile Asn Thr Val 
                165                 170                 175     


Ala Gln Ala Leu His Leu Leu Ser Thr Leu Tyr Gly Pro Phe Pro Asn 
            180                 185                 190         


Cys Tyr Gly Ile Gly Arg Cys Ala Lys Met Ala Tyr Glu Leu Trp Arg 
        195                 200                 205             


Asn Leu Glu Glu Glu Glu Asp Gly Glu Thr Lys Gly Arg Arg Pro Glu 
    210                 215                 220                 


Ile Gly His Ile Phe Leu Leu Asp Arg Asp Val Asp Phe Val Thr Ala 
225                 230                 235                 240 


Leu Cys Ser Gln Val Val Tyr Glu Gly Leu Val Asp Asp Thr Phe Arg 
                245                 250                 255     


Ile Lys Cys Gly Ser Val Asp Phe Gly Pro Glu Val Thr Ser Ser Asp 
            260                 265                 270         


Lys Ser Leu Lys Val Leu Leu Asn Ala Glu Asp Lys Val Phe Asn Glu 
        275                 280                 285             


Ile Arg Asn Glu His Phe Ser Asn Val Phe Gly Phe Leu Ser Gln Lys 
    290                 295                 300                 


Ala Arg Asn Leu Gln Ala Gln Tyr Asp Arg Arg Arg Gly Met Asp Ile 
305                 310                 315                 320 


Lys Gln Met Lys Asn Phe Val Ser Gln Glu Leu Lys Gly Leu Lys Gln 
                325                 330                 335     


Glu His Arg Leu Leu Ser Leu His Ile Gly Ala Cys Glu Ser Ile Met 
            340                 345                 350         


Lys Lys Lys Thr Lys Gln Asp Phe Gln Glu Leu Ile Lys Thr Glu His 
        355                 360                 365             


Ala Leu Leu Glu Gly Phe Asn Ile Arg Glu Ser Thr Ser Tyr Ile Glu 
    370                 375                 380                 


Glu His Ile Asp Arg Gln Val Ser Pro Ile Glu Ser Leu Arg Leu Met 
385                 390                 395                 400 


Cys Leu Leu Ser Ile Thr Glu Asn Gly Leu Ile Pro Lys Asp Tyr Arg 
                405                 410                 415     


Ser Leu Lys Thr Gln Tyr Leu Gln Ser Tyr Gly Pro Glu His Leu Leu 
            420                 425                 430         


Thr Phe Ser Asn Leu Arg Arg Ala Gly Leu Leu Thr Glu Gln Ala Pro 
        435                 440                 445             


Gly Asp Thr Leu Thr Ala Val Glu Ser Lys Val Ser Lys Leu Val Thr 
    450                 455                 460                 


Asp Lys Ala Ala Gly Lys Ile Thr Asp Ala Phe Ser Ser Leu Ala Lys 
465                 470                 475                 480 


Arg Ser Asn Phe Arg Ala Ile Ser Lys Lys Leu Asn Leu Ile Pro Arg 
                485                 490                 495     


Val Asp Gly Glu Tyr Asp Leu Lys Val Pro Arg Asp Met Ala Tyr Val 
            500                 505                 510         


Phe Ser Gly Ala Tyr Val Pro Leu Ser Cys Arg Ile Ile Glu Gln Val 
        515                 520                 525             


Leu Glu Arg Arg Ser Trp Gln Gly Leu Asp Glu Val Val Arg Leu Leu 
    530                 535                 540                 


Asn Cys Ser Asp Phe Ala Phe Thr Asp Met Thr Lys Glu Asp Lys Ala 
545                 550                 555                 560 


Ser Ser Glu Ser Leu Arg Leu Ile Leu Val Val Phe Leu Gly Gly Cys 
                565                 570                 575     


Thr Phe Ser Glu Ile Ser Ala Leu Arg Phe Leu Gly Arg Glu Lys Gly 
            580                 585                 590         


Tyr Arg Phe Ile Phe Leu Thr Thr Ala Val Thr Asn Ser Ala Arg Leu 
        595                 600                 605             


Met Glu Ala Met Ser Glu Val Lys Ala 
    610                 615         


<210>  3364
<211>  2740
<212>  DNA
<213>  Homosapiens

<400>  3364
ggcggcggcg gcggcggcga agaactgttc cttccacctc ttcagccccg gcaggacggg     60

ggcggccgcc gcgaacccgg ggcggggaca gcacgcagcc tcgaggcgcg cacccccgcc    120

cggcagcggc cccgacaccc ggggcgagcg ggaaaacggc aacggcggcg gcggcggcgg    180

cggcggggga aggatgcagg ggaagaagcc gggcggttcg tcgggcggcg gccggagcgg    240

cgagctgcag ggggacgagg cgcagaggaa caagaaaaag aaaaagaagg tgtcctgctt    300

ttccaacatc aagatcttcc tggtgtccga gtgcgccctg atgctggcgc agggcacggt    360

gggcgcctac ctggtgagcg tcctgaccac cctggagcgt aggttcaacc tgcagagcgc    420

tgacgtgggt gtgatcgcta gcagcttcga gatcgggaac ctggcgctca tcctcttcgt    480

gagctacttc ggggcacgcg ggcaccggcc gcgcctgatc ggctgcggcg gcatcgtcat    540

ggcgctgggc gcgctgctgt cggcgctgcc cgagttcctg acccaccagt acaagtacga    600

ggcgggcgag atccgctggg gcgccgaggg ccgcgacgtc tgcgcagcca acggctcggg    660

cggcgacgag gggcccgacc ccgacctcat ctgccgcaac cggacggcta ccaacatgat    720

gtacttgctg ctcattgggg cccaggtgct cctgggcatc ggtgctaccc ctgtgcagcc    780

cctgggcgtc tcctactacg acgaccacgt gcggaggaag gactcctcgc tctatatagg    840

aatcctgttc acgatgctgg tatttggacc agcctgcggg tttatcctgg gctctttctg    900

taccaaaatc tacgtggatg cggtcttcat tgacacaagt aacctggaca tcactccgga    960

cgacccccgc tggatcggag cctggtgggg tggctttctg ctctgcggtg ccttactctt   1020

cttctcttcc ctcttgatgt ttgggtttcc acagtccctg cccccgcact cagaccccgc   1080

catggaaagc gagcaggcca tgctctccga aagagaatac gagagaccca agcccagcaa   1140

cggggtcctg aggcaccccc tggagccaga cagcagtgcc tcctgtttcc agcagctgag   1200

agtgatcccg aaggtcacca agcacctgct ctcaaaccct gtgttcacct gcatcatcct   1260

ggccgcctgc atggagattg cagtggtggc tggcttcgct gcctttttgg ggaagtacct   1320

ggagcagcag tttaacctca ccacctcttc tgccaaccag ctgcttggga tgactgcgat   1380

cccgtgtgct tgtctgggta tcttcctggg aggtcttttg gtgaagaagc tcagcctgtc   1440

tgccctgggg gccattcgga tggccatgct cgtcaacctg gtgtccactg cttgctacgt   1500

ctccttcctc ttcctgggct gcgacactgg ccctgtggct ggggttactg ttccctatgg   1560

aaacagcaca gcacctggct cagccctgga cccctactcg ccctgcaata ataactgtga   1620

atgccaaacc gattccttca ctccagtgtg tggggcagat ggcatcacct acctgtctgc   1680

ctgctttgct ggctgcaaca gcacgaatct cacgggctgt gcgtgcctca ccaccgtccc   1740

tgctgagaac gcaaccgtgg ttcctggaaa atgccccagt cctgggtgcc aagaggcctt   1800

cctcactttc ctctgtgtga tgtgtatctg cagcctgatc ggtgccatgg cacagacacc   1860

ctcagtcatc atcctcatca ggacagtcag ccctgaactc aagtcttacg ctttgggagt   1920

tctttttctc ctccttcgtt tgttgggctt catccctcca cccctcatct tcggggctgg   1980

catcgactcc acctgcctgt tctggagcac gttctgtggg gagcaaggcg cctgcgtcct   2040

ctacgacaat gtggtctacc gatacctgta tgtcagcatc gccatcgcgc tcaaatcctt   2100

cgccttcatc ctgtacacca ccacgtggca gtgcctgagg aaaaactata aacgctacat   2160

caaaaaccac gagggcgggc tgagcaccag tgagttcttt gcctctactc tgaccctaga   2220

caacctgggg agggaccctg tgcccgcaaa ccagacacat aggacaaagt ttatctataa   2280

cctggaagac catgagtggt gtgaaaacat ggagtccgtt ttatagtgac taaaggaggg   2340

ctgaactctg tattagtaat ccaagggtca tttttttctt aaaaaaagaa aaaaaggttc   2400

caaaaaaaac caaaactcag tacacacaca caggcacaga tgcacacaca cgcagacaga   2460

cacaccgact ttgtcctttt tctcagcatc agagccagac aggattcaga ataaggagag   2520

aatgacatcg tgcggcaggg tcctggaggc cactcgcgcg gctgggccac agagtctact   2580

ttgaaggcac ctcatggttt tcaggatgct gacagctgca agcaacaggc actgccaaat   2640

tcagggaaca gtggtggcca gcttggagga tggacatttc tggatacaca tacacataca   2700

aaacagaaaa cattttttaa aagaagtttc ctaaaataaa                         2740


<210>  3365
<211>  710
<212>  PRT
<213>  Homosapiens

<400>  3365

Met Gln Gly Lys Lys Pro Gly Gly Ser Ser Gly Gly Gly Arg Ser Gly 
1               5                   10                  15      


Glu Leu Gln Gly Asp Glu Ala Gln Arg Asn Lys Lys Lys Lys Lys Lys 
            20                  25                  30          


Val Ser Cys Phe Ser Asn Ile Lys Ile Phe Leu Val Ser Glu Cys Ala 
        35                  40                  45              


Leu Met Leu Ala Gln Gly Thr Val Gly Ala Tyr Leu Val Ser Val Leu 
    50                  55                  60                  


Thr Thr Leu Glu Arg Arg Phe Asn Leu Gln Ser Ala Asp Val Gly Val 
65                  70                  75                  80  


Ile Ala Ser Ser Phe Glu Ile Gly Asn Leu Ala Leu Ile Leu Phe Val 
                85                  90                  95      


Ser Tyr Phe Gly Ala Arg Gly His Arg Pro Arg Leu Ile Gly Cys Gly 
            100                 105                 110         


Gly Ile Val Met Ala Leu Gly Ala Leu Leu Ser Ala Leu Pro Glu Phe 
        115                 120                 125             


Leu Thr His Gln Tyr Lys Tyr Glu Ala Gly Glu Ile Arg Trp Gly Ala 
    130                 135                 140                 


Glu Gly Arg Asp Val Cys Ala Ala Asn Gly Ser Gly Gly Asp Glu Gly 
145                 150                 155                 160 


Pro Asp Pro Asp Leu Ile Cys Arg Asn Arg Thr Ala Thr Asn Met Met 
                165                 170                 175     


Tyr Leu Leu Leu Ile Gly Ala Gln Val Leu Leu Gly Ile Gly Ala Thr 
            180                 185                 190         


Pro Val Gln Pro Leu Gly Val Ser Tyr Tyr Asp Asp His Val Arg Arg 
        195                 200                 205             


Lys Asp Ser Ser Leu Tyr Ile Gly Ile Leu Phe Thr Met Leu Val Phe 
    210                 215                 220                 


Gly Pro Ala Cys Gly Phe Ile Leu Gly Ser Phe Cys Thr Lys Ile Tyr 
225                 230                 235                 240 


Val Asp Ala Val Phe Ile Asp Thr Ser Asn Leu Asp Ile Thr Pro Asp 
                245                 250                 255     


Asp Pro Arg Trp Ile Gly Ala Trp Trp Gly Gly Phe Leu Leu Cys Gly 
            260                 265                 270         


Ala Leu Leu Phe Phe Ser Ser Leu Leu Met Phe Gly Phe Pro Gln Ser 
        275                 280                 285             


Leu Pro Pro His Ser Asp Pro Ala Met Glu Ser Glu Gln Ala Met Leu 
    290                 295                 300                 


Ser Glu Arg Glu Tyr Glu Arg Pro Lys Pro Ser Asn Gly Val Leu Arg 
305                 310                 315                 320 


His Pro Leu Glu Pro Asp Ser Ser Ala Ser Cys Phe Gln Gln Leu Arg 
                325                 330                 335     


Val Ile Pro Lys Val Thr Lys His Leu Leu Ser Asn Pro Val Phe Thr 
            340                 345                 350         


Cys Ile Ile Leu Ala Ala Cys Met Glu Ile Ala Val Val Ala Gly Phe 
        355                 360                 365             


Ala Ala Phe Leu Gly Lys Tyr Leu Glu Gln Gln Phe Asn Leu Thr Thr 
    370                 375                 380                 


Ser Ser Ala Asn Gln Leu Leu Gly Met Thr Ala Ile Pro Cys Ala Cys 
385                 390                 395                 400 


Leu Gly Ile Phe Leu Gly Gly Leu Leu Val Lys Lys Leu Ser Leu Ser 
                405                 410                 415     


Ala Leu Gly Ala Ile Arg Met Ala Met Leu Val Asn Leu Val Ser Thr 
            420                 425                 430         


Ala Cys Tyr Val Ser Phe Leu Phe Leu Gly Cys Asp Thr Gly Pro Val 
        435                 440                 445             


Ala Gly Val Thr Val Pro Tyr Gly Asn Ser Thr Ala Pro Gly Ser Ala 
    450                 455                 460                 


Leu Asp Pro Tyr Ser Pro Cys Asn Asn Asn Cys Glu Cys Gln Thr Asp 
465                 470                 475                 480 


Ser Phe Thr Pro Val Cys Gly Ala Asp Gly Ile Thr Tyr Leu Ser Ala 
                485                 490                 495     


Cys Phe Ala Gly Cys Asn Ser Thr Asn Leu Thr Gly Cys Ala Cys Leu 
            500                 505                 510         


Thr Thr Val Pro Ala Glu Asn Ala Thr Val Val Pro Gly Lys Cys Pro 
        515                 520                 525             


Ser Pro Gly Cys Gln Glu Ala Phe Leu Thr Phe Leu Cys Val Met Cys 
    530                 535                 540                 


Ile Cys Ser Leu Ile Gly Ala Met Ala Gln Thr Pro Ser Val Ile Ile 
545                 550                 555                 560 


Leu Ile Arg Thr Val Ser Pro Glu Leu Lys Ser Tyr Ala Leu Gly Val 
                565                 570                 575     


Leu Phe Leu Leu Leu Arg Leu Leu Gly Phe Ile Pro Pro Pro Leu Ile 
            580                 585                 590         


Phe Gly Ala Gly Ile Asp Ser Thr Cys Leu Phe Trp Ser Thr Phe Cys 
        595                 600                 605             


Gly Glu Gln Gly Ala Cys Val Leu Tyr Asp Asn Val Val Tyr Arg Tyr 
    610                 615                 620                 


Leu Tyr Val Ser Ile Ala Ile Ala Leu Lys Ser Phe Ala Phe Ile Leu 
625                 630                 635                 640 


Tyr Thr Thr Thr Trp Gln Cys Leu Arg Lys Asn Tyr Lys Arg Tyr Ile 
                645                 650                 655     


Lys Asn His Glu Gly Gly Leu Ser Thr Ser Glu Phe Phe Ala Ser Thr 
            660                 665                 670         


Leu Thr Leu Asp Asn Leu Gly Arg Asp Pro Val Pro Ala Asn Gln Thr 
        675                 680                 685             


His Arg Thr Lys Phe Ile Tyr Asn Leu Glu Asp His Glu Trp Cys Glu 
    690                 695                 700                 


Asn Met Glu Ser Val Leu 
705                 710 


<210>  3366
<211>  2600
<212>  DNA
<213>  Homosapiens

<400>  3366
acatgcgccc tgacagccca acaatggcgg cgcccgcgga gtcgctgagg aggcggaaga     60

ctgggtactc ggatccggag cctgagtcgc cgcccgcgcc ggggcgtggc cccgcaggct    120

ctccggccca tcttcacacg ggcaccttct ggctgacccg gatcgtgctc ctgaaggccc    180

tagccttcgt gtacttcgtg gcattcctgg tggctttcca tcagaacaag cagctcatcg    240

gtgacagggg gctgcttccc tgcagagtgt tcctgaagga cttccagcag tacttccagg    300

acaggacaag ctgggaagtc ttcagctaca tgcccaccat cctctggctg atggactggt    360

cagacatgaa ctccaacctg gacttgctgg ctcttctcgg actgggcatc tcgtctttcg    420

tactgatcac gggttgcgcc aacatgcttc tcatggctgc cctgtggggc ctctacatgt    480

ccctggttaa tgtgggccat gtctggtact ctttcggatg ggagtcccag cttctggaga    540

cgggattcct ggggatcttc ctgtgccctc tgtggacgct gtcaaggctg ccccagcata    600

cccccacatc ccggattgtc ctgtggggct tccggtggct gatcttcagg atcatgcttg    660

gagcaggcct gatcaagatc cggggggacc ggtgctggcg agacctcacc tgcatggact    720

tccactatga gacccagccg atgcccaatc ctgtggcata ctacctgcac cactcaccct    780

ggtggttcca tcgcttcgag acgctcagca accacttcat cgagctcctg gtgcccttct    840

tcctcttcct cggccggcgg gcgtgcatca tccacggggt gctgcagatc ctgttccagg    900

ccgtcctcat cgtcagcggg aacctcagct tcctgaactg gctgactatg gtgcccagcc    960

tggcctgctt tgatgacgcc accctgggat tcttgttccc ctctgggcca ggcagcctga   1020

aggaccgagt tctgcagatg cagagggaca tccgaggggc ccggcccgag cccagattcg   1080

gctccgtggt gcggcgtgca gccaacgtct cgctgggcgt cctgctggcc tggctcagcg   1140

tgcccgtggt cctcaacttg ctgagctcca ggcaggtcat gaacacccac ttcaactctc   1200

ttcacatcgt caacacttac ggggccttcg gaagcatcac caaggagcgg gcggaggtga   1260

tcctgcaggg cacagccagc tccaacgcca gcgcccccga tgccatgtgg gaggactacg   1320

agttcaagtg caagccaggt gaccccagca gacggccctg cctcatctcc ccgtaccact   1380

accgcctgga ctggctgatg tggttcgcgg ccttccagac ctacgagcac aacgactgga   1440

tcatccacct ggctggcaag ctcctggcca gcgacgccga ggccttgtcc ctgctggcac   1500

acaacccctt cgcgggcagg cccccgccca ggtgggtccg aggagagcac tacaggtaca   1560

agttcagccg tcctgggggc aggcacgccg ccgagggcaa gtggtgggtg cggaagagga   1620

tcggagccta cttccctccg ctcagcctgg aggagctgag gccctacttc agggaccgtg   1680

ggtggcctct gcccgggccc ctctagacgt gcaccagaaa taaaggcgaa gacccagccc   1740

ctcggcggct cagcaacgtt tgcccttccc tgcgcccagc ccaagctggg catcgccaag   1800

agagacgtgg agaggagagc ggtgggaccc agcccccagc acgggggtcc agggtggggt   1860

ctgttgtcac atactgtggc ggctcccagg ccctgcccac ctggggcccc acatccaggc   1920

caacccttgt cccaggcgcc aggggctctg atctcccatc catcccaccc tcctcccaga   1980

ggcccagcct ggggctgtgc cgcccacagg agttgagaca atggcaatcc tgacaccttc   2040

ctccactaca gccctgacca tagacccagc caggtagctc ttggggtctc tagcgtccca   2100

gggcctggtt tctgttccct cttcaatggt gtgttcccag ccaggtcctg accctcagag   2160

ccaagtccct gtcacgtctg gggcagccaa accctcgccc cacagggacc tggacacgcc   2220

cggccaggat gtggggttgg atgggccatt ttctgtccta tccctcatct ccacccccgc   2280

cacagcctac acgcatccca cacatgcagg cacacacagc ctgtgcacac atgtgttctt   2340

ggcccggttt catcccccca tgactggtgt ctgtgaggtg cagatggaca cagcgcacac   2400

ccagaccctc caccaggctg tgacctcgct gcctctgagg ccttgacaag gcccctcaat   2460

cggaggacag ccggccgtgc acactttcat catcgtcgga caaacagcgt ctactgcaca   2520

tttttcttat tcctattctt gagccatagc tatggcatat tcttctacta ttcctattat   2580

accacttacc agcttactcg                                               2600


<210>  3367
<211>  567
<212>  PRT
<213>  Homosapiens

<400>  3367

Met Arg Pro Asp Ser Pro Thr Met Ala Ala Pro Ala Glu Ser Leu Arg 
1               5                   10                  15      


Arg Arg Lys Thr Gly Tyr Ser Asp Pro Glu Pro Glu Ser Pro Pro Ala 
            20                  25                  30          


Pro Gly Arg Gly Pro Ala Gly Ser Pro Ala His Leu His Thr Gly Thr 
        35                  40                  45              


Phe Trp Leu Thr Arg Ile Val Leu Leu Lys Ala Leu Ala Phe Val Tyr 
    50                  55                  60                  


Phe Val Ala Phe Leu Val Ala Phe His Gln Asn Lys Gln Leu Ile Gly 
65                  70                  75                  80  


Asp Arg Gly Leu Leu Pro Cys Arg Val Phe Leu Lys Asp Phe Gln Gln 
                85                  90                  95      


Tyr Phe Gln Asp Arg Thr Ser Trp Glu Val Phe Ser Tyr Met Pro Thr 
            100                 105                 110         


Ile Leu Trp Leu Met Asp Trp Ser Asp Met Asn Ser Asn Leu Asp Leu 
        115                 120                 125             


Leu Ala Leu Leu Gly Leu Gly Ile Ser Ser Phe Val Leu Ile Thr Gly 
    130                 135                 140                 


Cys Ala Asn Met Leu Leu Met Ala Ala Leu Trp Gly Leu Tyr Met Ser 
145                 150                 155                 160 


Leu Val Asn Val Gly His Val Trp Tyr Ser Phe Gly Trp Glu Ser Gln 
                165                 170                 175     


Leu Leu Glu Thr Gly Phe Leu Gly Ile Phe Leu Cys Pro Leu Trp Thr 
            180                 185                 190         


Leu Ser Arg Leu Pro Gln His Thr Pro Thr Ser Arg Ile Val Leu Trp 
        195                 200                 205             


Gly Phe Arg Trp Leu Ile Phe Arg Ile Met Leu Gly Ala Gly Leu Ile 
    210                 215                 220                 


Lys Ile Arg Gly Asp Arg Cys Trp Arg Asp Leu Thr Cys Met Asp Phe 
225                 230                 235                 240 


His Tyr Glu Thr Gln Pro Met Pro Asn Pro Val Ala Tyr Tyr Leu His 
                245                 250                 255     


His Ser Pro Trp Trp Phe His Arg Phe Glu Thr Leu Ser Asn His Phe 
            260                 265                 270         


Ile Glu Leu Leu Val Pro Phe Phe Leu Phe Leu Gly Arg Arg Ala Cys 
        275                 280                 285             


Ile Ile His Gly Val Leu Gln Ile Leu Phe Gln Ala Val Leu Ile Val 
    290                 295                 300                 


Ser Gly Asn Leu Ser Phe Leu Asn Trp Leu Thr Met Val Pro Ser Leu 
305                 310                 315                 320 


Ala Cys Phe Asp Asp Ala Thr Leu Gly Phe Leu Phe Pro Ser Gly Pro 
                325                 330                 335     


Gly Ser Leu Lys Asp Arg Val Leu Gln Met Gln Arg Asp Ile Arg Gly 
            340                 345                 350         


Ala Arg Pro Glu Pro Arg Phe Gly Ser Val Val Arg Arg Ala Ala Asn 
        355                 360                 365             


Val Ser Leu Gly Val Leu Leu Ala Trp Leu Ser Val Pro Val Val Leu 
    370                 375                 380                 


Asn Leu Leu Ser Ser Arg Gln Val Met Asn Thr His Phe Asn Ser Leu 
385                 390                 395                 400 


His Ile Val Asn Thr Tyr Gly Ala Phe Gly Ser Ile Thr Lys Glu Arg 
                405                 410                 415     


Ala Glu Val Ile Leu Gln Gly Thr Ala Ser Ser Asn Ala Ser Ala Pro 
            420                 425                 430         


Asp Ala Met Trp Glu Asp Tyr Glu Phe Lys Cys Lys Pro Gly Asp Pro 
        435                 440                 445             


Ser Arg Arg Pro Cys Leu Ile Ser Pro Tyr His Tyr Arg Leu Asp Trp 
    450                 455                 460                 


Leu Met Trp Phe Ala Ala Phe Gln Thr Tyr Glu His Asn Asp Trp Ile 
465                 470                 475                 480 


Ile His Leu Ala Gly Lys Leu Leu Ala Ser Asp Ala Glu Ala Leu Ser 
                485                 490                 495     


Leu Leu Ala His Asn Pro Phe Ala Gly Arg Pro Pro Pro Arg Trp Val 
            500                 505                 510         


Arg Gly Glu His Tyr Arg Tyr Lys Phe Ser Arg Pro Gly Gly Arg His 
        515                 520                 525             


Ala Ala Glu Gly Lys Trp Trp Val Arg Lys Arg Ile Gly Ala Tyr Phe 
    530                 535                 540                 


Pro Pro Leu Ser Leu Glu Glu Leu Arg Pro Tyr Phe Arg Asp Arg Gly 
545                 550                 555                 560 


Trp Pro Leu Pro Gly Pro Leu 
                565         


<210>  3368
<211>  3069
<212>  DNA
<213>  Homosapiens

<400>  3368
ggcgagggtc ggggccaccg cgcggcgacc tcgggtcccg gagcgaccgc agggcagccc     60

cgggcgccgg ccccggtgcg cgtctcctgt gcgcgcccct ccgcgcgcgg ccccgatgct    120

ggacatgagc gaggcccgct cccagccgcc ctgcagcccg tccggcaccg ccagctccat    180

gtcgcacgtg gaggactcgg actcggacgc gccgccgtct cccgccggct ccgagggcct    240

gggccgcgcg ggggtcgcgg tggggggcgc ccggggcgac ccggcggagg cggcggacga    300

gcgcttcccg gcctgcatcc gcgacgccgt gtcgcaggtg ctcaagggct acgactggag    360

tctggtgccc atgccggtgc gcggcggcgg cggcggcgcg ctcaaagcca agccgcatgt    420

gaagcggccc atgaacgcat tcatggtgtg ggcgcaggcg gcgcgccgca agctggccga    480

ccagtacccg cacctgcaca acgccgagct cagcaagacg ctgggcaagc tgtggcgctt    540

gctgagcgag agcgagaagc ggcccttcgt ggaggaggca gagcgccttc gcgtgcagca    600

caagaaggac caccccgact acaagtacca gccacggcgc aggaagagcg ccaaagccgg    660

ccacagcgac tccgactcgg gcgcggagct gggaccccac cctggcggcg gtgccgtgta    720

caaggctgaa gcagggcttg gagatgggca ccaccatggc gaccacacag ggcagaccca    780

cgggccgccc accccgccca ccacccccaa gacggagctg cagcaggcgg gcgccaagcc    840

ggagctgaag ctggagggac gccggccggt ggacagcggg cgccagaaca tcgacttcag    900

caacgtggac atctcggagc tcagcagcga ggtcatgggc accatggacg ccttcgacgt    960

ccacgagttc gaccagtacc tgcccctggg cggccccgcc ccacccgagc cgggccaggc   1020

ctatgggggc gcctacttcc acgccggggc gtcccccgtg tgggcccaca agagtgcccc   1080

gtcggcctcc gcgtcgccca ccgagacggg tcccccacgg ccgcacatca agacggagca   1140

gccgagcccc ggccactacg gcgaccagcc ccgaggctcg cccgactacg gttcctgcag   1200

cggccagtcc agcgccaccc cggccgcccc cgccggcccc ttcgccggct cacagggcga   1260

ctatggcgac ctgcaggcct ccagctacta tggtgcctac cctggctacg cacccggcct   1320

ctaccagtac ccctgcttcc actcgccgcg ccggccctac gcctcacccc tgctcaacgg   1380

cctggccctg ccgcccgccc acagccccac cagtcactgg gaccagccgg tgtacaccac   1440

cctgaccagg ccctgagggc ccagccgcgg ggagggactc gcaggcgtca gggggcagcc   1500

ttgtcccggc ccagtgtgtg tgaccagggc gggaggggcc ccagtggctg agctccaagt   1560

gcctgctgaa gtctgcaggg aaacacgctt gctgcccgtg gccctcggcc tccagatggc   1620

cacacctctg ccgacgacgg accagctccc tctcccttct atctttcttt ttgaggtggt   1680

gggattattc cacaaagaag ggctgccgtt tggtccctct tccgtgagga ctggcggcac   1740

cagcaccttc gctttgcatc tcggtagagg agaaacggca gcacagccca aggaccaaag   1800

gagggggtgg caggggcctt gcagggcgct gtgaggtcca ggccggtctt ggcgccgaga   1860

gcccctgcac tcaaggccac attccctcga caacggctgc acgggctgtc cgggatccgg   1920

ggtgtctgtc cgcagactgg gatgagtcta ctcgagcatc tccgggacct gcctgtcaga   1980

tctgaggtgt ctccttgctg gcagagtgcg ctcacgcgag ggctggctgt gatgaacaca   2040

tctctctttt atttttatgt ttttgataat ttttattttt gaagcttaaa tgtgtttctt   2100

ctgaaagctg ttaaagatgt atttatgttc tgtgttattt tatctttaat taatgaggta   2160

attcgggcaa agagtagaat ttaagacaaa acggaagctg ggaagcttcc cttgagggca   2220

ggcaggaggt ggagttgcag ctgttggccg gcatcacgtt gctcgttgct cggcttatgg   2280

gaggccgccc tggagggccc ggaggtccca aggtccctgg gaggactggg cccctcatgc   2340

ctcgagcttg gcaaccgaaa acccgaggga ggagaaggga cctgccttgt gacatctctg   2400

atcaggttgg ggtgccccag cacccagtac cagtttgggg tttgggaagc aggactccgt   2460

ccctgtcccc gactgtgcca cgtggtagga cacataggac acaggaattc ctgggtcctt   2520

gcccatgact gtgccatgtg gtaggacaca ggacacagga attcctggaa agtggtggct   2580

tcagaagtga tcttggctcg caggcaccag tgccacctac caagctgtga aactaaacct   2640

tctccactaa acgtcgttag ggcctcagtt ctagacgagt catacctgat tcacctgcac   2700

tgcttcccct gtgtgctgag catagagcat acaatagcgc ctacttcacg gaaacttgtg   2760

cctttaaact ttgtaaactt aaacacagcc gagaagttgc ttctttgtac tttttctact   2820

tttcctactt ttttgtagaa aaaaaagata atgcctctgc ttctatttct ctgggggtgg   2880

gggtgggggc cgggagccgt cgcagacccg tttcatgcag cgtctccctt ggcaccgcgt   2940

tcggaggacg caccctcact cccctgctgc cttcactcct ttctgaccaa gcaacgctaa   3000

cttttgtaca gatcgatttg ataaaattaa acaaagtgct ttttatggaa aaaaaaaaaa   3060

aaaaaaaaa                                                           3069


<210>  3369
<211>  446
<212>  PRT
<213>  Homosapiens

<400>  3369

Met Leu Asp Met Ser Glu Ala Arg Ser Gln Pro Pro Cys Ser Pro Ser 
1               5                   10                  15      


Gly Thr Ala Ser Ser Met Ser His Val Glu Asp Ser Asp Ser Asp Ala 
            20                  25                  30          


Pro Pro Ser Pro Ala Gly Ser Glu Gly Leu Gly Arg Ala Gly Val Ala 
        35                  40                  45              


Val Gly Gly Ala Arg Gly Asp Pro Ala Glu Ala Ala Asp Glu Arg Phe 
    50                  55                  60                  


Pro Ala Cys Ile Arg Asp Ala Val Ser Gln Val Leu Lys Gly Tyr Asp 
65                  70                  75                  80  


Trp Ser Leu Val Pro Met Pro Val Arg Gly Gly Gly Gly Gly Ala Leu 
                85                  90                  95      


Lys Ala Lys Pro His Val Lys Arg Pro Met Asn Ala Phe Met Val Trp 
            100                 105                 110         


Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro His Leu His 
        115                 120                 125             


Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg Leu Leu Ser 
    130                 135                 140                 


Glu Ser Glu Lys Arg Pro Phe Val Glu Glu Ala Glu Arg Leu Arg Val 
145                 150                 155                 160 


Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro Arg Arg Arg 
                165                 170                 175     


Lys Ser Ala Lys Ala Gly His Ser Asp Ser Asp Ser Gly Ala Glu Leu 
            180                 185                 190         


Gly Pro His Pro Gly Gly Gly Ala Val Tyr Lys Ala Glu Ala Gly Leu 
        195                 200                 205             


Gly Asp Gly His His His Gly Asp His Thr Gly Gln Thr His Gly Pro 
    210                 215                 220                 


Pro Thr Pro Pro Thr Thr Pro Lys Thr Glu Leu Gln Gln Ala Gly Ala 
225                 230                 235                 240 


Lys Pro Glu Leu Lys Leu Glu Gly Arg Arg Pro Val Asp Ser Gly Arg 
                245                 250                 255     


Gln Asn Ile Asp Phe Ser Asn Val Asp Ile Ser Glu Leu Ser Ser Glu 
            260                 265                 270         


Val Met Gly Thr Met Asp Ala Phe Asp Val His Glu Phe Asp Gln Tyr 
        275                 280                 285             


Leu Pro Leu Gly Gly Pro Ala Pro Pro Glu Pro Gly Gln Ala Tyr Gly 
    290                 295                 300                 


Gly Ala Tyr Phe His Ala Gly Ala Ser Pro Val Trp Ala His Lys Ser 
305                 310                 315                 320 


Ala Pro Ser Ala Ser Ala Ser Pro Thr Glu Thr Gly Pro Pro Arg Pro 
                325                 330                 335     


His Ile Lys Thr Glu Gln Pro Ser Pro Gly His Tyr Gly Asp Gln Pro 
            340                 345                 350         


Arg Gly Ser Pro Asp Tyr Gly Ser Cys Ser Gly Gln Ser Ser Ala Thr 
        355                 360                 365             


Pro Ala Ala Pro Ala Gly Pro Phe Ala Gly Ser Gln Gly Asp Tyr Gly 
    370                 375                 380                 


Asp Leu Gln Ala Ser Ser Tyr Tyr Gly Ala Tyr Pro Gly Tyr Ala Pro 
385                 390                 395                 400 


Gly Leu Tyr Gln Tyr Pro Cys Phe His Ser Pro Arg Arg Pro Tyr Ala 
                405                 410                 415     


Ser Pro Leu Leu Asn Gly Leu Ala Leu Pro Pro Ala His Ser Pro Thr 
            420                 425                 430         


Ser His Trp Asp Gln Pro Val Tyr Thr Thr Leu Thr Arg Pro 
        435                 440                 445     


<210>  3370
<211>  2866
<212>  DNA
<213>  Homosapiens

<400>  3370
ggaaaataag ccaggagagg aaggagcggc gggcaggtgg ccccgggagc ccagacggac     60

ggctgctgtc gatatggcga cagctgccct gtggccgccc ctgcacccag atggcgcctg    120

gcctggccgc agcatcctgg agtctgaggc cagcacctgc gtctccctga agcccctcag    180

agcctgccct gcagtgctgc tgccctcgtc taccagtggc tcaagcctgt catcccagca    240

ctgtgggagg ccgaggcggg tggatcacct gaggacagga gttcaagacc agcctgggca    300

acatggctat atggaaagca caggtgtttc tgcttctgga gaggccccag gaagcttcca    360

accgtggtgg aaggcgaagc gggagcaggt gtctcacatg gcgtgagcgg gaacgagaaa    420

gacagagcag ggaaacgtgc agaggaaatg gttggagagc gaagtccagg cacaggggcc    480

atgagagccg gaccccacgc agctgcagac cccgacccga actgcatgcg gctgaggacc    540

cccaagccag gcagaccccg acccagaccc cacgcggccg cggacccccg acctcgaccc    600

aaactgcatg cggctgagga cccccaagcc aggcagacgc caatccagac cccacgcggc    660

cgcggacccc aacccagaca gaccccgacc cacccgtgca gcccccagcc ccaaaagtca    720

aaccccagcg tccccccagg gcggcccggg ctccctcaga tacagcagct tcctgaggtg    780

gcctcacccg caactccaga ccaatcagag aaggccaaat gggctcccca agcccagcag    840

gtgggacccc cgatctagag agccccttcc ccgccccagg ccaacagcca ccctcgggct    900

ccgcatcagg tctgccaaat gcaggggcga ggggccgacc ccgccacggg aaccaaactc    960

aggaaacagc ccatccagcg tccatctcca tccggacccg ccgccgcggc cgcaggttca   1020

cgcgccgttc cgcggagatc tctcaggcgc ctctggcccg gcagaaaccc gcggttccga   1080

tgacagaggt cctggtggga atcgcaccgc ctgccgttcc tgcctccgcg gaggatgcgc   1140

tgccctaaac tgcccccggc tcttcatccc ccaacccccg gcagcctccg accctccccc   1200

ggccggcgca gctcagcctt tcgcagacgc gggggagctg gaatccgacc acgcgcagcc   1260

ttctcaccgt ggtgcacgct tcgggccccc cacgcctttc ccaggcttca tcacccattt   1320

ctctccagcg ctgaaggaaa cctcccagat gcttctccac tcacccaccg aagcaggtct   1380

cggttgcccc cagccccggg ccctcccgag aacactgcaa gcccccactg gtcccctccc   1440

ggcaacccca cggcccatcc ccaaacctgc actcaccctg tggggcctcc accctttgga   1500

ggaaggacgt gtcaaagctt ggaggtgcgc ggcctgtcta acctccgccc aaggcgcgcg   1560

gcaggcgaca ggtctcagcc cggatcagcg tggtccaaaa ggacttatcg ttaaaagtgc   1620

tggtcccaga acccaagggg aagacatgct ggttctctga tgagctgggc cgcctcctcc   1680

aggaagcctc ctccttggag ctctgtagcc atcgtgggct tgcaagagtc aaagggcctg   1740

gcccacagcg gcgcccggca ctgagctgga cagtgtcctg cccccaaaat tcatgtccgc   1800

ccagaacctc agaatgcaac cttccctggt agtagggctt tgcagatgta attaaggatc   1860

tggggacgag gtcaccctgg attgaggctg agtcccaagt cagtcactgg tgttcctcca   1920

tgaagagcag agcagaatag agacagatgc acagagcagg ccctgtgagg acagaggcag   1980

ggactggagc gtcggccgca gcaggggcgt ggagccccca gagctggaag agggagggat   2040

cctccccagg gcctccggaa ggagtgtgct gcgtgctgcc cacaccgtga ttttggactc   2100

gtggcatcca gaactgggag agaataaatt tctgatgttg taagcctgca ctacagcagc   2160

cccaggacgc tgaaatagtt cagccggtgc aggctcctcc ctccctccct ctctcttgtt   2220

gtgagatatt ttttagacgg ggtctcacct gtcgctggag tgcagtggtg tgatcatagc   2280

tcactggagc ctctaatgcc tgggctcaag cgatcctccc acctcagcct cccgagtagc   2340

tgggactaca ggtgccatca gacctggcta atttttaaaa atctttttag agatggggga   2400

ggtctcccta tgtggcccag gctggccttg aactcttggg ctcaagtgat cctcttgcct   2460

tggcctccca aagtgttagg atggcaggct tgagccacca tgcctggcag ctccatctgt   2520

gttgactcct gaagcccctc atcttggcta atccggacag gcttgctggg gaccccatct   2580

ccccttggag actttgggat gtggctggat gtccaagtgg ccggggtcct ccacagcccc   2640

cagcttccca gggcgggagg caggctgtgt cctcggtggg cactgacagt gaggctgaaa   2700

tgtttgcact tcacatttcc acatttaggg gcattttgtt gttgactcat tcaaagctct   2760

tttaagtcgc ttaatttgct gctcagaggg aaatgaaaag ggagccattt tccctgattt   2820

gtttgcctca tcaacttttc aatcaataaa aaagtgcatt ttgctc                  2866


<210>  3371
<211>  350
<212>  PRT
<213>  Homosapiens

<400>  3371

Met Arg Leu Arg Thr Pro Lys Pro Gly Arg Arg Gln Ser Arg Pro His 
1               5                   10                  15      


Ala Ala Ala Asp Pro Asn Pro Asp Arg Pro Arg Pro Thr Arg Ala Ala 
            20                  25                  30          


Pro Ser Pro Lys Ser Gln Thr Pro Ala Ser Pro Gln Gly Gly Pro Gly 
        35                  40                  45              


Ser Leu Arg Tyr Ser Ser Phe Leu Arg Trp Pro His Pro Gln Leu Gln 
    50                  55                  60                  


Thr Asn Gln Arg Arg Pro Asn Gly Leu Pro Lys Pro Ser Arg Trp Asp 
65                  70                  75                  80  


Pro Arg Ser Arg Glu Pro Leu Pro Arg Pro Arg Pro Thr Ala Thr Leu 
                85                  90                  95      


Gly Leu Arg Ile Arg Ser Ala Lys Cys Arg Gly Glu Gly Pro Thr Pro 
            100                 105                 110         


Pro Arg Glu Pro Asn Ser Gly Asn Ser Pro Ser Ser Val His Leu His 
        115                 120                 125             


Pro Asp Pro Pro Pro Arg Pro Gln Val His Ala Pro Phe Arg Gly Asp 
    130                 135                 140                 


Leu Ser Gly Ala Ser Gly Pro Ala Glu Thr Arg Gly Ser Asp Asp Arg 
145                 150                 155                 160 


Gly Pro Gly Gly Asn Arg Thr Ala Cys Arg Ser Cys Leu Arg Gly Gly 
                165                 170                 175     


Cys Ala Ala Leu Asn Cys Pro Arg Leu Phe Ile Pro Gln Pro Pro Ala 
            180                 185                 190         


Ala Ser Asp Pro Pro Pro Ala Gly Ala Ala Gln Pro Phe Ala Asp Ala 
        195                 200                 205             


Gly Glu Leu Glu Ser Asp His Ala Gln Pro Ser His Arg Gly Ala Arg 
    210                 215                 220                 


Phe Gly Pro Pro Thr Pro Phe Pro Gly Phe Ile Thr His Phe Ser Pro 
225                 230                 235                 240 


Ala Leu Lys Glu Thr Ser Gln Met Leu Leu His Ser Pro Thr Glu Ala 
                245                 250                 255     


Gly Leu Gly Cys Pro Gln Pro Arg Ala Leu Pro Arg Thr Leu Gln Ala 
            260                 265                 270         


Pro Thr Gly Pro Leu Pro Ala Thr Pro Arg Pro Ile Pro Lys Pro Ala 
        275                 280                 285             


Leu Thr Leu Trp Gly Leu His Pro Leu Glu Glu Gly Arg Val Lys Ala 
    290                 295                 300                 


Trp Arg Cys Ala Ala Cys Leu Thr Ser Ala Gln Gly Ala Arg Gln Ala 
305                 310                 315                 320 


Thr Gly Leu Ser Pro Asp Gln Arg Gly Pro Lys Gly Leu Ile Val Lys 
                325                 330                 335     


Ser Ala Gly Pro Arg Thr Gln Gly Glu Asp Met Leu Val Leu 
            340                 345                 350 


<210>  3372
<211>  3986
<212>  DNA
<213>  Homosapiens

<400>  3372
gagcctgcgg cgtgcagtgt gaggggcggg acccggctgc cggcggtggg tctagctggg     60

ggaggtcggg ccatgctggt gggccagggc gcggggctgc tggggcccgc ggtggtcacc    120

gccgcggtgg tgctgctgct gagcggcgtg gggccggcgc acggctcgga ggacatcgtg    180

gtgggctgcg gtggcttcgt caagtcggac gtggagatca actactcgct catcgagata    240

aagctgtaca ccaagcatgg gactttgaaa taccagacag actgtgcccc taataatggt    300

tactttatga tccctttgta tgataagggg gatttcattc tgaagattga gcctccccta    360

gggtggagtt ttgagccgac gaccgtggag ctccatgtgg atggagtcag tgacatctgc    420

acaaagggtg gggacatcaa ctttgtcttc actgggttct ctgtgaatgg caaggtcctc    480

agcaaagggc agcccctggg tcctgcggga gttcaggtgt ctctgagaaa cactgggacc    540

gaagcaaaga tccagtccac agttacacag cctggcggaa agtttgcatt ttttaaagtt    600

ctgcctggag attatgaaat cctcgcaact catccaacct gggcgttgaa agaggcaagc    660

accacagtgc gtgtaaccaa ctccaatgcc aatgcggcca gtcccctcat agttgctggc    720

tacaatgtgt ctggctctgt ccgaagtgat ggggagccca tgaaaggggt gaagtttctt    780

ctcttttctt ctttagtaac taaagaggat gtcctgggct gcaatgtctc accagtgcct    840

gggttccagc cccaagacga gagtctggtg tatttgtgct acacggtctc cagagaagat    900

ggctcgttct ctttctattc cttgccaagt gggggctaca ctgtgattcc gttctatcga    960

ggggagagga ttacctttga tgtggcgcct tccagacttg acttcacagt ggagcatgac   1020

agcttgaaaa tcgagcccgt gttccacgtc atgggattct ccgtcaccgg gagggtcttg   1080

aacggacccg aaggagatgg tgttccagaa gcagtagtca ccctgaataa ccaaatcaaa   1140

gttaaaacaa aagctgatgg ctcattccgc cttgagaaca taaccacagg gacatacacc   1200

atccatgctc agaaagagca cctctacttt gaaacggtca ccatcaaaat tgcaccgaac   1260

acacctcagc tggctgacat tgttgcaaca gggttcagtg tctgtggtcg gatatcaatc   1320

attcgcttcc cggacaccgt caagcagatg aataaataca aagttgtcct gtcatctcaa   1380

gacaaggaca agtctttggt caccgtggag acagatgctc atggatcatt ttgttttaaa   1440

gcaaaaccag ggacttacaa agtgcaggtg atggttcctg aggcagaaac cagagcaggg   1500

ctgacgttga aaccccagac atttcctctt actgtgaccg acaggcccgt gatggatgtg   1560

gcctttgtac agttcttggc atcagtttct gggaaagtct cttgtttgga cacctgtggt   1620

gacttgctgg tgactctaca gtccctgagc cgccagggtg agaagcggag cctccagctc   1680

tccggcaagg tcaacgccat gactttcacc tttgacaacg tgctccctgg aaaatacaaa   1740

ataagcatca tgcatgagga ttggtgctgg aagaacaaga gcctggaggt ggaagtgctg   1800

gaggatgacg tgtctgcagt tgagttcagg cagacgggct acatgctgag atgttccctg   1860

tctcacgcca tcactctgga attttatcag gatggaaatg ggcgtgagaa tgtggggatt   1920

tataacctct ccaaaggagt caaccgattc tgcctgtcca agcctggtgt gtacaaagtg   1980

acccctcgct cctgccaccg gtttgagcaa gcgttctaca cctatgacac gtcttcacct   2040

agtatcttga cattgacagc cattcgccac catgtccttg gaactatcac caccgacaaa   2100

atgatggatg tcactgtgac tatcaagtct tccatcgaca gtgaacccgc cttggtctta   2160

ggccctctga agtctgtgca ggagctgcgg agggagcagc agctggctga gatcgaggcc   2220

cgcaggcagg agagggagaa aaacggcaat gaggaaggtg aagaaagaat gaccaagcct   2280

cccgtgcagg agatggtaga tgagttacaa ggccccttct cgtatgattt ctcttactgg   2340

gcgcggtctg gagagaaaat cactgttaca ccgtcatcta aagagctgct cttttatccc   2400

ccttcaatgg aagccgttgt cagtggagaa agctgcccag ggaagctgat cgagatccac   2460

gggaaggcag gcctgttttt agaaggccag atccaccccg agttggaagg agtcgagatt   2520

gtcatcagtg aaaagggggc aagttcaccg ctgatcacag tctttactga tgacaaaggt   2580

gcctacagtg ttggccccct gcacagtgac ctggagtaca cggtgacctc acagaaggag   2640

ggctatgttc tgactgcagt ggaaggaacc atcggagact tcaaggccta tgccctggca   2700

ggcgtaagct ttgagataaa agctgaggat gaccagcccc tcccgggagt cctcttatcc   2760

ctgagtggtg gcctgtttcg ttccaacctc ttgacccagg acaacggcat tctgacattc   2820

tcaaacctga gccctggcca gtattacttc aaacccatga tgaaggagtt ccggtttgag   2880

ccatcctcac agatgatcga ggtgcaggaa ggccagaacc tgaagatcac catcacgggg   2940

taccgaaccg cttacagttg ctatggcaca gtgtcttcct taaacggaga gcccgaacaa   3000

ggggttgcca tggaagcggt gggccagaac gactgcagca tttacggaga agacaccgtg   3060

acagacgaag agggcaagtt cagattacgt ggattgctgc cgggatgtgt gtaccacgtt   3120

cagctcaagg cagaaggcaa cgaccacatt gagcgggcgc tcccccacca tagggtgatt   3180

gaggttggga ataatgacat cgatgatgta aacatcatag ttttccggca gattaatcaa   3240

tttgatttaa gtggaaatgt gatcacttcc tctgaatacc ttcctacgtt atgggtcaag   3300

ctttacaaaa gcgaaaacct cgacaatcca atccagacag tttcccttgg ccagtccctg   3360

ttcttccatt tccccccact gctcagagat ggcgagaact atgttgtgct tctggactcc   3420

acactcccca gatcccagta tgactacatc ttgcctcaag tttctttcac cgcagtgggc   3480

taccataaac acatcacctt gatttttaat cccacgagga agctgcctga acaggacatc   3540

gcacaaggat cctacattgc cctgccattg acgctgctgg ttctgctggc cggttacaac   3600

catgacaagc tcattccttt gctgctgcag ttgacaagcc ggctacaggg agtcggcgcg   3660

ctcggccagg cagcctctga caatagcggc ccagaagatg caaagagaca agccaagaaa   3720

cagaagacaa ggcggaccct tcgtttgcaa gaagagttcc agttgatgtg gtgtttggtt   3780

ccatggcggg gtaccctagg gattcatctg ttttcttcac ttccctttgc atctgagatc   3840

ctgctggaaa ccacggcaac ctgtatccac tattaggagg taaaaatcaa taaaatggcc   3900

cattcatttg tgttgtagct caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3960

aaaaaaaaaa aaaaaaaaaa aaaaaa                                        3986


<210>  3373
<211>  1267
<212>  PRT
<213>  Homosapiens

<400>  3373

Met Leu Val Gly Gln Gly Ala Gly Leu Leu Gly Pro Ala Val Val Thr 
1               5                   10                  15      


Ala Ala Val Val Leu Leu Leu Ser Gly Val Gly Pro Ala His Gly Ser 
            20                  25                  30          


Glu Asp Ile Val Val Gly Cys Gly Gly Phe Val Lys Ser Asp Val Glu 
        35                  40                  45              


Ile Asn Tyr Ser Leu Ile Glu Ile Lys Leu Tyr Thr Lys His Gly Thr 
    50                  55                  60                  


Leu Lys Tyr Gln Thr Asp Cys Ala Pro Asn Asn Gly Tyr Phe Met Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Lys Gly Asp Phe Ile Leu Lys Ile Glu Pro Pro Leu 
                85                  90                  95      


Gly Trp Ser Phe Glu Pro Thr Thr Val Glu Leu His Val Asp Gly Val 
            100                 105                 110         


Ser Asp Ile Cys Thr Lys Gly Gly Asp Ile Asn Phe Val Phe Thr Gly 
        115                 120                 125             


Phe Ser Val Asn Gly Lys Val Leu Ser Lys Gly Gln Pro Leu Gly Pro 
    130                 135                 140                 


Ala Gly Val Gln Val Ser Leu Arg Asn Thr Gly Thr Glu Ala Lys Ile 
145                 150                 155                 160 


Gln Ser Thr Val Thr Gln Pro Gly Gly Lys Phe Ala Phe Phe Lys Val 
                165                 170                 175     


Leu Pro Gly Asp Tyr Glu Ile Leu Ala Thr His Pro Thr Trp Ala Leu 
            180                 185                 190         


Lys Glu Ala Ser Thr Thr Val Arg Val Thr Asn Ser Asn Ala Asn Ala 
        195                 200                 205             


Ala Ser Pro Leu Ile Val Ala Gly Tyr Asn Val Ser Gly Ser Val Arg 
    210                 215                 220                 


Ser Asp Gly Glu Pro Met Lys Gly Val Lys Phe Leu Leu Phe Ser Ser 
225                 230                 235                 240 


Leu Val Thr Lys Glu Asp Val Leu Gly Cys Asn Val Ser Pro Val Pro 
                245                 250                 255     


Gly Phe Gln Pro Gln Asp Glu Ser Leu Val Tyr Leu Cys Tyr Thr Val 
            260                 265                 270         


Ser Arg Glu Asp Gly Ser Phe Ser Phe Tyr Ser Leu Pro Ser Gly Gly 
        275                 280                 285             


Tyr Thr Val Ile Pro Phe Tyr Arg Gly Glu Arg Ile Thr Phe Asp Val 
    290                 295                 300                 


Ala Pro Ser Arg Leu Asp Phe Thr Val Glu His Asp Ser Leu Lys Ile 
305                 310                 315                 320 


Glu Pro Val Phe His Val Met Gly Phe Ser Val Thr Gly Arg Val Leu 
                325                 330                 335     


Asn Gly Pro Glu Gly Asp Gly Val Pro Glu Ala Val Val Thr Leu Asn 
            340                 345                 350         


Asn Gln Ile Lys Val Lys Thr Lys Ala Asp Gly Ser Phe Arg Leu Glu 
        355                 360                 365             


Asn Ile Thr Thr Gly Thr Tyr Thr Ile His Ala Gln Lys Glu His Leu 
    370                 375                 380                 


Tyr Phe Glu Thr Val Thr Ile Lys Ile Ala Pro Asn Thr Pro Gln Leu 
385                 390                 395                 400 


Ala Asp Ile Val Ala Thr Gly Phe Ser Val Cys Gly Arg Ile Ser Ile 
                405                 410                 415     


Ile Arg Phe Pro Asp Thr Val Lys Gln Met Asn Lys Tyr Lys Val Val 
            420                 425                 430         


Leu Ser Ser Gln Asp Lys Asp Lys Ser Leu Val Thr Val Glu Thr Asp 
        435                 440                 445             


Ala His Gly Ser Phe Cys Phe Lys Ala Lys Pro Gly Thr Tyr Lys Val 
    450                 455                 460                 


Gln Val Met Val Pro Glu Ala Glu Thr Arg Ala Gly Leu Thr Leu Lys 
465                 470                 475                 480 


Pro Gln Thr Phe Pro Leu Thr Val Thr Asp Arg Pro Val Met Asp Val 
                485                 490                 495     


Ala Phe Val Gln Phe Leu Ala Ser Val Ser Gly Lys Val Ser Cys Leu 
            500                 505                 510         


Asp Thr Cys Gly Asp Leu Leu Val Thr Leu Gln Ser Leu Ser Arg Gln 
        515                 520                 525             


Gly Glu Lys Arg Ser Leu Gln Leu Ser Gly Lys Val Asn Ala Met Thr 
    530                 535                 540                 


Phe Thr Phe Asp Asn Val Leu Pro Gly Lys Tyr Lys Ile Ser Ile Met 
545                 550                 555                 560 


His Glu Asp Trp Cys Trp Lys Asn Lys Ser Leu Glu Val Glu Val Leu 
                565                 570                 575     


Glu Asp Asp Val Ser Ala Val Glu Phe Arg Gln Thr Gly Tyr Met Leu 
            580                 585                 590         


Arg Cys Ser Leu Ser His Ala Ile Thr Leu Glu Phe Tyr Gln Asp Gly 
        595                 600                 605             


Asn Gly Arg Glu Asn Val Gly Ile Tyr Asn Leu Ser Lys Gly Val Asn 
    610                 615                 620                 


Arg Phe Cys Leu Ser Lys Pro Gly Val Tyr Lys Val Thr Pro Arg Ser 
625                 630                 635                 640 


Cys His Arg Phe Glu Gln Ala Phe Tyr Thr Tyr Asp Thr Ser Ser Pro 
                645                 650                 655     


Ser Ile Leu Thr Leu Thr Ala Ile Arg His His Val Leu Gly Thr Ile 
            660                 665                 670         


Thr Thr Asp Lys Met Met Asp Val Thr Val Thr Ile Lys Ser Ser Ile 
        675                 680                 685             


Asp Ser Glu Pro Ala Leu Val Leu Gly Pro Leu Lys Ser Val Gln Glu 
    690                 695                 700                 


Leu Arg Arg Glu Gln Gln Leu Ala Glu Ile Glu Ala Arg Arg Gln Glu 
705                 710                 715                 720 


Arg Glu Lys Asn Gly Asn Glu Glu Gly Glu Glu Arg Met Thr Lys Pro 
                725                 730                 735     


Pro Val Gln Glu Met Val Asp Glu Leu Gln Gly Pro Phe Ser Tyr Asp 
            740                 745                 750         


Phe Ser Tyr Trp Ala Arg Ser Gly Glu Lys Ile Thr Val Thr Pro Ser 
        755                 760                 765             


Ser Lys Glu Leu Leu Phe Tyr Pro Pro Ser Met Glu Ala Val Val Ser 
    770                 775                 780                 


Gly Glu Ser Cys Pro Gly Lys Leu Ile Glu Ile His Gly Lys Ala Gly 
785                 790                 795                 800 


Leu Phe Leu Glu Gly Gln Ile His Pro Glu Leu Glu Gly Val Glu Ile 
                805                 810                 815     


Val Ile Ser Glu Lys Gly Ala Ser Ser Pro Leu Ile Thr Val Phe Thr 
            820                 825                 830         


Asp Asp Lys Gly Ala Tyr Ser Val Gly Pro Leu His Ser Asp Leu Glu 
        835                 840                 845             


Tyr Thr Val Thr Ser Gln Lys Glu Gly Tyr Val Leu Thr Ala Val Glu 
    850                 855                 860                 


Gly Thr Ile Gly Asp Phe Lys Ala Tyr Ala Leu Ala Gly Val Ser Phe 
865                 870                 875                 880 


Glu Ile Lys Ala Glu Asp Asp Gln Pro Leu Pro Gly Val Leu Leu Ser 
                885                 890                 895     


Leu Ser Gly Gly Leu Phe Arg Ser Asn Leu Leu Thr Gln Asp Asn Gly 
            900                 905                 910         


Ile Leu Thr Phe Ser Asn Leu Ser Pro Gly Gln Tyr Tyr Phe Lys Pro 
        915                 920                 925             


Met Met Lys Glu Phe Arg Phe Glu Pro Ser Ser Gln Met Ile Glu Val 
    930                 935                 940                 


Gln Glu Gly Gln Asn Leu Lys Ile Thr Ile Thr Gly Tyr Arg Thr Ala 
945                 950                 955                 960 


Tyr Ser Cys Tyr Gly Thr Val Ser Ser Leu Asn Gly Glu Pro Glu Gln 
                965                 970                 975     


Gly Val Ala Met Glu Ala Val Gly Gln Asn Asp Cys Ser Ile Tyr Gly 
            980                 985                 990         


Glu Asp Thr Val Thr Asp Glu Glu  Gly Lys Phe Arg Leu  Arg Gly Leu 
        995                 1000                 1005             


Leu Pro  Gly Cys Val Tyr His  Val Gln Leu Lys Ala  Glu Gly Asn 
    1010                 1015                 1020             


Asp His  Ile Glu Arg Ala Leu  Pro His His Arg Val  Ile Glu Val 
    1025                 1030                 1035             


Gly Asn  Asn Asp Ile Asp Asp  Val Asn Ile Ile Val  Phe Arg Gln 
    1040                 1045                 1050             


Ile Asn  Gln Phe Asp Leu Ser  Gly Asn Val Ile Thr  Ser Ser Glu 
    1055                 1060                 1065             


Tyr Leu  Pro Thr Leu Trp Val  Lys Leu Tyr Lys Ser  Glu Asn Leu 
    1070                 1075                 1080             


Asp Asn  Pro Ile Gln Thr Val  Ser Leu Gly Gln Ser  Leu Phe Phe 
    1085                 1090                 1095             


His Phe  Pro Pro Leu Leu Arg  Asp Gly Glu Asn Tyr  Val Val Leu 
    1100                 1105                 1110             


Leu Asp  Ser Thr Leu Pro Arg  Ser Gln Tyr Asp Tyr  Ile Leu Pro 
    1115                 1120                 1125             


Gln Val  Ser Phe Thr Ala Val  Gly Tyr His Lys His  Ile Thr Leu 
    1130                 1135                 1140             


Ile Phe  Asn Pro Thr Arg Lys  Leu Pro Glu Gln Asp  Ile Ala Gln 
    1145                 1150                 1155             


Gly Ser  Tyr Ile Ala Leu Pro  Leu Thr Leu Leu Val  Leu Leu Ala 
    1160                 1165                 1170             


Gly Tyr  Asn His Asp Lys Leu  Ile Pro Leu Leu Leu  Gln Leu Thr 
    1175                 1180                 1185             


Ser Arg  Leu Gln Gly Val Gly  Ala Leu Gly Gln Ala  Ala Ser Asp 
    1190                 1195                 1200             


Asn Ser  Gly Pro Glu Asp Ala  Lys Arg Gln Ala Lys  Lys Gln Lys 
    1205                 1210                 1215             


Thr Arg  Arg Thr Leu Arg Leu  Gln Glu Glu Phe Gln  Leu Met Trp 
    1220                 1225                 1230             


Cys Leu  Val Pro Trp Arg Gly  Thr Leu Gly Ile His  Leu Phe Ser 
    1235                 1240                 1245             


Ser Leu  Pro Phe Ala Ser Glu  Ile Leu Leu Glu Thr  Thr Ala Thr 
    1250                 1255                 1260             


Cys Ile  His Tyr 
    1265         


<210>  3374
<211>  4317
<212>  DNA
<213>  Homosapiens

<400>  3374
gagcctgcgg cgtgcagtgt gaggggcggg acccggctgc cggcggtggg tctagctggg     60

ggaggtcggg ccatgctggt gggccagggc gcggggctgc tggggcccgc ggtggtcacc    120

gccgcggtgg tgctgctgct gagcggcgtg gggccggcgc acggctcgga ggacatcgtg    180

gtgggctgcg gtggcttcgt caagtcggac gtggagatca actactcgct catcgagata    240

aagctgtaca ccaagcatgg gactttgaaa taccagacag actgtgcccc taataatggt    300

tactttatga tccctttgta tgataagggg gatttcattc tgaagattga gcctccccta    360

gggtggagtt ttgagccgac gaccgtggag ctccatgtgg atggagtcag tgacatctgc    420

acaaagggtg gggacatcaa ctttgtcttc actgggttct ctgtgaatgg caaggtcctc    480

agcaaagggc agcccctggg tcctgcggga gttcaggtgt ctctgagaaa cactgggacc    540

gaagcaaaga tccagtccac agttacacag cctggcggaa agtttgcatt ttttaaagtt    600

ctgcctggag attatgaaat cctcgcaact catccaacct gggcgttgaa agaggcaagc    660

accacagtgc gtgtaaccaa ctccaatgcc aatgcggcca gtcccctcat agttgctggc    720

tacaatgtgt ctggctctgt ccgaagtgat ggggagccca tgaaaggggt gaagtttctt    780

ctcttttctt ctttagtaac taaagaggat gtcctgggct gcaatgtctc accagtgcct    840

gggttccagc cccaagacga gagtctggtg tatttgtgct acacggtctc cagagaagat    900

ggctcgttct ctttctattc cttgccaagt gggggctaca ctgtgattcc gttctatcga    960

ggggagagga ttacctttga tgtggcgcct tccagacttg acttcacagt ggagcatgac   1020

agcttgaaaa tcgagcccgt gttccacgtc atgggattct ccgtcaccgg gagggtcttg   1080

aacggacccg aaggagatgg tgttccagaa gcagtagtca ccctgaataa ccaaatcaaa   1140

gttaaaacaa aagctgatgg ctcattccgc cttgagaaca taaccacagg gacatacacc   1200

atccatgctc agaaagagca cctctacttt gaaacggtca ccatcaaaat tgcaccgaac   1260

acacctcagc tggctgacat tgttgcaaca gggttcagtg tctgtggtcg gatatcaatc   1320

attcgcttcc cggacaccgt caagcagatg aataaataca aagttgtcct gtcatctcaa   1380

gacaaggaca agtctttggt caccgtggag acagatgctc atggatcatt ttgttttaaa   1440

gcaaaaccag ggacttacaa agtgcaggtg atggttcctg aggcagaaac cagagcaggg   1500

ctgacgttga aaccccagac atttcctctt actgtgaccg acaggcccgt gatggatgtg   1560

gcctttgtac agttcttggc atcagtttct gggaaagtct cttgtttgga cacctgtggt   1620

gacttgctgg tgactctaca gtccctgagc cgccagggtg agaagcggag cctccagctc   1680

tccggcaagg tcaacgccat gactttcacc tttgacaacg tgctccctgg aaaatacaaa   1740

ataagcatca tgcatgagga ttggtgctgg aagaacaaga gcctggaggt ggaagtgctg   1800

gaggatgacg tgtctgcagt tgagttcagg cagacgggct acatgctgag atgttccctg   1860

tctcacgcca tcactctgga attttatcag gatggaaatg ggcgtgagaa tgtggggatt   1920

tataacctct ccaaaggagt caaccgattc tgcctgtcca agcctggtgt gtacaaagtg   1980

acccctcgct cctgccaccg gtttgagcaa gcgttctaca cctatgacac gtcttcacct   2040

agtatcttga cattgacagc cattcgccac catgtccttg gaactatcac caccgacaaa   2100

atgatggatg tcactgtgac tatcaagtct tccatcgaca gtgaacccgc cttggtctta   2160

ggccctctga agtctgtgca ggagctgcgg agggagcagc agctggctga gatcgaggcc   2220

cgcaggcagg agagggagaa aaacggcaat gaggaaggtg aagaaagaat gaccaagcct   2280

cccgtgcagg agatggtaga tgagttacaa ggccccttct cgtatgattt ctcttactgg   2340

gcgcggtctg gagagaaaat cactgttaca ccgtcatcta aagagctgct cttttatccc   2400

ccttcaatgg aagccgttgt cagtggagaa agctgcccag ggaagctgat cgagatccac   2460

gggaaggcag gcctgttttt agaaggccag atccaccccg agttggaagg agtcgagatt   2520

gtcatcagtg aaaagggggc aagttcaccg ctgatcacag tctttactga tgacaaaggt   2580

gcctacagtg ttggccccct gcacagtgac ctggagtaca cggtgacctc acagaaggag   2640

ggctatgttc tgactgcagt ggaaggaacc atcggagact tcaaggccta tgccctggca   2700

ggcgtaagct ttgagataaa agctgaggat gaccagcccc tcccgggagt cctcttatcc   2760

ctgagtggtg gcctgtttcg ttccaacctc ttgacccagg acaacggcat tctgacattc   2820

tcaaacctga gccctggcca gtattacttc aaacccatga tgaaggagtt ccggtttgag   2880

ccatcctcac agatgatcga ggtgcaggaa ggccagaacc tgaagatcac catcacgggg   2940

taccgaaccg cttacagttg ctatggcaca gtgtcttcct taaacggaga gcccgaacaa   3000

ggggttgcca tggaagcggt gggccagaac gactgcagca tttacggaga agacaccgtg   3060

acagacgaag agggcaagtt cagattacgt ggattgctgc cgggatgtgt gtaccacgtt   3120

cagctcaagg cagaaggcaa cgaccacatt gagcgggcgc tcccccacca tagggtgatt   3180

gaggttggga ataatgacat cgatgatgta aacatcatag ttttccggca gattaatcaa   3240

tttgatttaa gtggaaatgt gatcacttcc tctgaatacc ttcctacgtt atgggtcaag   3300

ctttacaaaa gcgaaaacct cgacaatcca atccagacag tttcccttgg ccagtccctg   3360

ttcttccatt tccccccact gctcagagat ggcgagaact atgttgtgct tctggactcc   3420

acactcccca gatcccagta tgactacatc ttgcctcaag tttctttcac cgcagtgggc   3480

taccataaac acatcacctt gatttttaat cccacgagga agctgcctga acaggacatc   3540

gcacaaggat cctacattgc cctgccattg acgctgctgg ttctgctggc cggttacaac   3600

catgacaagc tcattccttt gctgctgcag ttgacaagcc ggctacaggg agtcggcgcg   3660

ctcggccagg cagcctctga caatagcggc ccagaagatg caaagagaca agccaagaaa   3720

cagaagacaa ggcggacgtg aggaggaagg ggacagttgc agtctcactt gggacaggcc   3780

acagccaggg gtccggccac tacccgcccg tgggataaaa gccaaaagca tgcgtcagct   3840

aacttcagcc tgtgctgctg ggcccgcacc ccatgtccct tgtcactgtg gcatcctgca   3900

cccatcctca cccctccgta gagcccctcg tgcaatgcaa tgaatggacc ctcctgtcac   3960

tctgctgaac agaatttatt ttctgagtca aatataattt attattattt ttgtcaaaga   4020

agtatttaag ctgtgctgtg gtgtgagaat gtcattcttg atcttcagcc ttcgtttgca   4080

agaagagttc cagttgatgt ggtgtttggt tccatggcgg ggtaccctag ggattcatct   4140

gttttcttca cttccctttg catctgagat cctgctggaa accacggcaa cctgtatcca   4200

ctattaggag gtaaaaatca ataaaatggc ccattcattt gtgttgtagc tcaaaaaaaa   4260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa      4317


<210>  3375
<211>  1222
<212>  PRT
<213>  Homosapiens

<400>  3375

Met Leu Val Gly Gln Gly Ala Gly Leu Leu Gly Pro Ala Val Val Thr 
1               5                   10                  15      


Ala Ala Val Val Leu Leu Leu Ser Gly Val Gly Pro Ala His Gly Ser 
            20                  25                  30          


Glu Asp Ile Val Val Gly Cys Gly Gly Phe Val Lys Ser Asp Val Glu 
        35                  40                  45              


Ile Asn Tyr Ser Leu Ile Glu Ile Lys Leu Tyr Thr Lys His Gly Thr 
    50                  55                  60                  


Leu Lys Tyr Gln Thr Asp Cys Ala Pro Asn Asn Gly Tyr Phe Met Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Lys Gly Asp Phe Ile Leu Lys Ile Glu Pro Pro Leu 
                85                  90                  95      


Gly Trp Ser Phe Glu Pro Thr Thr Val Glu Leu His Val Asp Gly Val 
            100                 105                 110         


Ser Asp Ile Cys Thr Lys Gly Gly Asp Ile Asn Phe Val Phe Thr Gly 
        115                 120                 125             


Phe Ser Val Asn Gly Lys Val Leu Ser Lys Gly Gln Pro Leu Gly Pro 
    130                 135                 140                 


Ala Gly Val Gln Val Ser Leu Arg Asn Thr Gly Thr Glu Ala Lys Ile 
145                 150                 155                 160 


Gln Ser Thr Val Thr Gln Pro Gly Gly Lys Phe Ala Phe Phe Lys Val 
                165                 170                 175     


Leu Pro Gly Asp Tyr Glu Ile Leu Ala Thr His Pro Thr Trp Ala Leu 
            180                 185                 190         


Lys Glu Ala Ser Thr Thr Val Arg Val Thr Asn Ser Asn Ala Asn Ala 
        195                 200                 205             


Ala Ser Pro Leu Ile Val Ala Gly Tyr Asn Val Ser Gly Ser Val Arg 
    210                 215                 220                 


Ser Asp Gly Glu Pro Met Lys Gly Val Lys Phe Leu Leu Phe Ser Ser 
225                 230                 235                 240 


Leu Val Thr Lys Glu Asp Val Leu Gly Cys Asn Val Ser Pro Val Pro 
                245                 250                 255     


Gly Phe Gln Pro Gln Asp Glu Ser Leu Val Tyr Leu Cys Tyr Thr Val 
            260                 265                 270         


Ser Arg Glu Asp Gly Ser Phe Ser Phe Tyr Ser Leu Pro Ser Gly Gly 
        275                 280                 285             


Tyr Thr Val Ile Pro Phe Tyr Arg Gly Glu Arg Ile Thr Phe Asp Val 
    290                 295                 300                 


Ala Pro Ser Arg Leu Asp Phe Thr Val Glu His Asp Ser Leu Lys Ile 
305                 310                 315                 320 


Glu Pro Val Phe His Val Met Gly Phe Ser Val Thr Gly Arg Val Leu 
                325                 330                 335     


Asn Gly Pro Glu Gly Asp Gly Val Pro Glu Ala Val Val Thr Leu Asn 
            340                 345                 350         


Asn Gln Ile Lys Val Lys Thr Lys Ala Asp Gly Ser Phe Arg Leu Glu 
        355                 360                 365             


Asn Ile Thr Thr Gly Thr Tyr Thr Ile His Ala Gln Lys Glu His Leu 
    370                 375                 380                 


Tyr Phe Glu Thr Val Thr Ile Lys Ile Ala Pro Asn Thr Pro Gln Leu 
385                 390                 395                 400 


Ala Asp Ile Val Ala Thr Gly Phe Ser Val Cys Gly Arg Ile Ser Ile 
                405                 410                 415     


Ile Arg Phe Pro Asp Thr Val Lys Gln Met Asn Lys Tyr Lys Val Val 
            420                 425                 430         


Leu Ser Ser Gln Asp Lys Asp Lys Ser Leu Val Thr Val Glu Thr Asp 
        435                 440                 445             


Ala His Gly Ser Phe Cys Phe Lys Ala Lys Pro Gly Thr Tyr Lys Val 
    450                 455                 460                 


Gln Val Met Val Pro Glu Ala Glu Thr Arg Ala Gly Leu Thr Leu Lys 
465                 470                 475                 480 


Pro Gln Thr Phe Pro Leu Thr Val Thr Asp Arg Pro Val Met Asp Val 
                485                 490                 495     


Ala Phe Val Gln Phe Leu Ala Ser Val Ser Gly Lys Val Ser Cys Leu 
            500                 505                 510         


Asp Thr Cys Gly Asp Leu Leu Val Thr Leu Gln Ser Leu Ser Arg Gln 
        515                 520                 525             


Gly Glu Lys Arg Ser Leu Gln Leu Ser Gly Lys Val Asn Ala Met Thr 
    530                 535                 540                 


Phe Thr Phe Asp Asn Val Leu Pro Gly Lys Tyr Lys Ile Ser Ile Met 
545                 550                 555                 560 


His Glu Asp Trp Cys Trp Lys Asn Lys Ser Leu Glu Val Glu Val Leu 
                565                 570                 575     


Glu Asp Asp Val Ser Ala Val Glu Phe Arg Gln Thr Gly Tyr Met Leu 
            580                 585                 590         


Arg Cys Ser Leu Ser His Ala Ile Thr Leu Glu Phe Tyr Gln Asp Gly 
        595                 600                 605             


Asn Gly Arg Glu Asn Val Gly Ile Tyr Asn Leu Ser Lys Gly Val Asn 
    610                 615                 620                 


Arg Phe Cys Leu Ser Lys Pro Gly Val Tyr Lys Val Thr Pro Arg Ser 
625                 630                 635                 640 


Cys His Arg Phe Glu Gln Ala Phe Tyr Thr Tyr Asp Thr Ser Ser Pro 
                645                 650                 655     


Ser Ile Leu Thr Leu Thr Ala Ile Arg His His Val Leu Gly Thr Ile 
            660                 665                 670         


Thr Thr Asp Lys Met Met Asp Val Thr Val Thr Ile Lys Ser Ser Ile 
        675                 680                 685             


Asp Ser Glu Pro Ala Leu Val Leu Gly Pro Leu Lys Ser Val Gln Glu 
    690                 695                 700                 


Leu Arg Arg Glu Gln Gln Leu Ala Glu Ile Glu Ala Arg Arg Gln Glu 
705                 710                 715                 720 


Arg Glu Lys Asn Gly Asn Glu Glu Gly Glu Glu Arg Met Thr Lys Pro 
                725                 730                 735     


Pro Val Gln Glu Met Val Asp Glu Leu Gln Gly Pro Phe Ser Tyr Asp 
            740                 745                 750         


Phe Ser Tyr Trp Ala Arg Ser Gly Glu Lys Ile Thr Val Thr Pro Ser 
        755                 760                 765             


Ser Lys Glu Leu Leu Phe Tyr Pro Pro Ser Met Glu Ala Val Val Ser 
    770                 775                 780                 


Gly Glu Ser Cys Pro Gly Lys Leu Ile Glu Ile His Gly Lys Ala Gly 
785                 790                 795                 800 


Leu Phe Leu Glu Gly Gln Ile His Pro Glu Leu Glu Gly Val Glu Ile 
                805                 810                 815     


Val Ile Ser Glu Lys Gly Ala Ser Ser Pro Leu Ile Thr Val Phe Thr 
            820                 825                 830         


Asp Asp Lys Gly Ala Tyr Ser Val Gly Pro Leu His Ser Asp Leu Glu 
        835                 840                 845             


Tyr Thr Val Thr Ser Gln Lys Glu Gly Tyr Val Leu Thr Ala Val Glu 
    850                 855                 860                 


Gly Thr Ile Gly Asp Phe Lys Ala Tyr Ala Leu Ala Gly Val Ser Phe 
865                 870                 875                 880 


Glu Ile Lys Ala Glu Asp Asp Gln Pro Leu Pro Gly Val Leu Leu Ser 
                885                 890                 895     


Leu Ser Gly Gly Leu Phe Arg Ser Asn Leu Leu Thr Gln Asp Asn Gly 
            900                 905                 910         


Ile Leu Thr Phe Ser Asn Leu Ser Pro Gly Gln Tyr Tyr Phe Lys Pro 
        915                 920                 925             


Met Met Lys Glu Phe Arg Phe Glu Pro Ser Ser Gln Met Ile Glu Val 
    930                 935                 940                 


Gln Glu Gly Gln Asn Leu Lys Ile Thr Ile Thr Gly Tyr Arg Thr Ala 
945                 950                 955                 960 


Tyr Ser Cys Tyr Gly Thr Val Ser Ser Leu Asn Gly Glu Pro Glu Gln 
                965                 970                 975     


Gly Val Ala Met Glu Ala Val Gly Gln Asn Asp Cys Ser Ile Tyr Gly 
            980                 985                 990         


Glu Asp Thr Val Thr Asp Glu Glu  Gly Lys Phe Arg Leu  Arg Gly Leu 
        995                 1000                 1005             


Leu Pro  Gly Cys Val Tyr His  Val Gln Leu Lys Ala  Glu Gly Asn 
    1010                 1015                 1020             


Asp His  Ile Glu Arg Ala Leu  Pro His His Arg Val  Ile Glu Val 
    1025                 1030                 1035             


Gly Asn  Asn Asp Ile Asp Asp  Val Asn Ile Ile Val  Phe Arg Gln 
    1040                 1045                 1050             


Ile Asn  Gln Phe Asp Leu Ser  Gly Asn Val Ile Thr  Ser Ser Glu 
    1055                 1060                 1065             


Tyr Leu  Pro Thr Leu Trp Val  Lys Leu Tyr Lys Ser  Glu Asn Leu 
    1070                 1075                 1080             


Asp Asn  Pro Ile Gln Thr Val  Ser Leu Gly Gln Ser  Leu Phe Phe 
    1085                 1090                 1095             


His Phe  Pro Pro Leu Leu Arg  Asp Gly Glu Asn Tyr  Val Val Leu 
    1100                 1105                 1110             


Leu Asp  Ser Thr Leu Pro Arg  Ser Gln Tyr Asp Tyr  Ile Leu Pro 
    1115                 1120                 1125             


Gln Val  Ser Phe Thr Ala Val  Gly Tyr His Lys His  Ile Thr Leu 
    1130                 1135                 1140             


Ile Phe  Asn Pro Thr Arg Lys  Leu Pro Glu Gln Asp  Ile Ala Gln 
    1145                 1150                 1155             


Gly Ser  Tyr Ile Ala Leu Pro  Leu Thr Leu Leu Val  Leu Leu Ala 
    1160                 1165                 1170             


Gly Tyr  Asn His Asp Lys Leu  Ile Pro Leu Leu Leu  Gln Leu Thr 
    1175                 1180                 1185             


Ser Arg  Leu Gln Gly Val Gly  Ala Leu Gly Gln Ala  Ala Ser Asp 
    1190                 1195                 1200             


Asn Ser  Gly Pro Glu Asp Ala  Lys Arg Gln Ala Lys  Lys Gln Lys 
    1205                 1210                 1215             


Thr Arg  Arg Thr 
    1220         


<210>  3376
<211>  554
<212>  DNA
<213>  Homosapiens

<400>  3376
ctctttccgc catctttccg cgccggtgag tagcactctc tgagagctcc aatttcatcc     60

gtctgccatc ggcgccatcc tgcaatctaa gccacaatgg tgcgcatgaa tgtcctggca    120

gatgctctca agagtatcaa caatgccgaa aagagaggca aacgccaggt gcttattagg    180

ccgtgctcca aagtcatcgt ccggtttctc actgtgatga tgaagcatgg ttacattggc    240

gaatttgaaa tcattgatga ccacagagct gggaaaattg ttgtgaacct cacaggcagg    300

ctaaacaagt gtggggtgat cagccccaga tttgacgtgc aactcaaaga cctggaaaaa    360

tggcagaata atctgcttcc atcccgccag tttggtttca ttgtactgac aacctcagct    420

ggcatcatgg accatgaaga agcaagacga aaacacacag gagggaaaat cctgggattc    480

tttttctagg gatgtaatac atatatttac aaataaaatg cctcatggac tctggtgctt    540

ccaaaaaaaa aaaa                                                      554


<210>  3377
<211>  130
<212>  PRT
<213>  Homosapiens

<400>  3377

Met Val Arg Met Asn Val Leu Ala Asp Ala Leu Lys Ser Ile Asn Asn 
1               5                   10                  15      


Ala Glu Lys Arg Gly Lys Arg Gln Val Leu Ile Arg Pro Cys Ser Lys 
            20                  25                  30          


Val Ile Val Arg Phe Leu Thr Val Met Met Lys His Gly Tyr Ile Gly 
        35                  40                  45              


Glu Phe Glu Ile Ile Asp Asp His Arg Ala Gly Lys Ile Val Val Asn 
    50                  55                  60                  


Leu Thr Gly Arg Leu Asn Lys Cys Gly Val Ile Ser Pro Arg Phe Asp 
65                  70                  75                  80  


Val Gln Leu Lys Asp Leu Glu Lys Trp Gln Asn Asn Leu Leu Pro Ser 
                85                  90                  95      


Arg Gln Phe Gly Phe Ile Val Leu Thr Thr Ser Ala Gly Ile Met Asp 
            100                 105                 110         


His Glu Glu Ala Arg Arg Lys His Thr Gly Gly Lys Ile Leu Gly Phe 
        115                 120                 125             


Phe Phe 
    130 


<210>  3378
<211>  488
<212>  DNA
<213>  Homosapiens

<400>  3378
ctctttccgc catctttccg cgccgccaca atggtgcgca tgaatgtcct ggcagatgct     60

ctcaagagta tcaacaatgc cgaaaagaga ggcaaacgcc aggtgcttat taggccgtgc    120

tccaaagtca tcgtccggtt tctcactgtg atgatgaagc atggttacat tggcgaattt    180

gaaatcattg atgaccacag agctgggaaa attgttgtga acctcacagg caggctaaac    240

aagtgtgggg tgatcagccc cagatttgac gtgcaactca aagacctgga aaaatggcag    300

aataatctgc ttccatcccg ccagtttggt ttcattgtac tgacaacctc agctggcatc    360

atggaccatg aagaagcaag acgaaaacac acaggaggga aaatcctggg attctttttc    420

tagggatgta atacatatat ttacaaataa aatgcctcat ggactctggt gcttccaaaa    480

aaaaaaaa                                                             488


<210>  3379
<211>  130
<212>  PRT
<213>  Homosapiens

<400>  3379

Met Val Arg Met Asn Val Leu Ala Asp Ala Leu Lys Ser Ile Asn Asn 
1               5                   10                  15      


Ala Glu Lys Arg Gly Lys Arg Gln Val Leu Ile Arg Pro Cys Ser Lys 
            20                  25                  30          


Val Ile Val Arg Phe Leu Thr Val Met Met Lys His Gly Tyr Ile Gly 
        35                  40                  45              


Glu Phe Glu Ile Ile Asp Asp His Arg Ala Gly Lys Ile Val Val Asn 
    50                  55                  60                  


Leu Thr Gly Arg Leu Asn Lys Cys Gly Val Ile Ser Pro Arg Phe Asp 
65                  70                  75                  80  


Val Gln Leu Lys Asp Leu Glu Lys Trp Gln Asn Asn Leu Leu Pro Ser 
                85                  90                  95      


Arg Gln Phe Gly Phe Ile Val Leu Thr Thr Ser Ala Gly Ile Met Asp 
            100                 105                 110         


His Glu Glu Ala Arg Arg Lys His Thr Gly Gly Lys Ile Leu Gly Phe 
        115                 120                 125             


Phe Phe 
    130 


<210>  3380
<211>  2280
<212>  DNA
<213>  Homosapiens

<400>  3380
gtgcgggttt cggttggagg actcgttggg gaggtggcct gcgcttgtag agactgcatc     60

cccgagacga tggcggaggg agataatcgc agcaccaacc tgctggctgc agagactgca    120

agtctggaag aacagctgca aggatgggga gaagtgatgc tgatggctga taaagtcctc    180

cgatgggaaa gagcctggtt tccacctgcc atcatgggtg tggtttcttt ggtgtttctg    240

attatctact atctagatcc atctgttctg tccggcgttt cctgttttgt tatgtttttg    300

tgcttggctg actaccttgt tcccattcta gcgcctagaa tttttggctc caataaatgg    360

accactgaac aacagcaaag attccatgaa atttgcagca atctagtaaa aactcgacgc    420

agagctgtgg gttggtggaa acgcctcttc acactaaagg aagaaaaacc taagatgtac    480

ttcatgacca tgatcgtttc ccttgctgcg gttgcttggg tgggacaaca agtccacaac    540

ctgcttctca cctacctgat agtgacttcc ttactattgc ttcctggact aaaccaacat    600

ggaatcattt tgaagtacat tggaatggcc aagagggaga taaacaaact tctcaaacaa    660

aaagaaaaga aaaacgaatg attcatctgc tttaatcagt gtgattaatg cagcacccat    720

tgccccggga accgtttctg ctgtactatc tggatactaa aatgttacgg aagtagctct    780

ttgttctccc tcactctgcc cttagttaat agaaattcag actcgccaag taaggcttcg    840

tgcatagtgt cttcatgtcg cgtatagttg agcgcgttct tagcagttgg cttcatggac    900

aactcattag tgttttgact tttcttaccc agcgttaatt gaattcttgc ttttagacaa    960

cttccttttt gtagtggtga accttgccct ttagtacagt tcaagtgaat ctggataatt   1020

gttcatcttt gctttagctt agataccatg tagtggtctg tggctacagg aagctggttc   1080

tgtctgcttc cacagtctgc ttaaaaaact gtctgacttc gtgaatatag agaccaagtt   1140

taccacttct gatgaagaga ccaattaaga ttcattcctc attctgtttc tttccagtgg   1200

gagaagagtc cccatgaaat aagatgaaac tgattccatg cactagtaca tgtaggcttc   1260

tcccttgtgc aaagcttagc aatttgtagg aaactttgat ctttttgtcc aagaaaagga   1320

atgtctgaca ggcttaagct ttcgtcccct tgcacttaga ctcgaagtta gtaaatcctt   1380

aaaggctttt taatagcaga cttccaaaag attgcattta ggatttctag catgctttta   1440

atttcagatt ttcagctgac attagctata gtatacagta ggttaagact catgtctatg   1500

actttcactc taagactggc aaaaggacag cagtcttcta tgtttagtca atattcattt   1560

cagtagaaga taatcttatc taatttttga gaccagaata agccttttaa ggtaaacctc   1620

aaaattatca ttttatggta atactgacca ttttagtccc ctaggtttga catgggagat   1680

agtgactaca ctggtgtctg acttttttcc tagagatttc tccctgaaaa atacaagggc   1740

tgttggtgag agcagacttg aggtgatgat agttggcctc tggtctacaa agatttcata   1800

actccttgga aagcttctta taatcattct taacttcttg gtagctagaa atttagagta   1860

gttgaaatct ttaggaatga acttctgagg gccaaaaaat gtgactgacg ggaacaattc   1920

ttaaactgat taactagctg taatatagtt ttgtgaattt attgcactga tgttgtacct   1980

tgtggtatat ctgtccctat taaataagtg ttgttttctc ctctttaata ttgctgtgaa   2040

cagtggtgcc cattgtagca tatgtttgat ttttttttat tatttcataa gaaaactacg   2100

ttaattttac cttactttca ttgtaaataa gcctgtcttc ctatctggat tttttgtgtg   2160

catacatatt ctactgatta actacttttg cagttttaat cctgtattat ttcttctact   2220

ttgttttgtg taaaagggga aaaaataaaa aaagctggaa tcttaaaaaa aaaaaaaaaa   2280


<210>  3381
<211>  203
<212>  PRT
<213>  Homosapiens

<400>  3381

Met Ala Glu Gly Asp Asn Arg Ser Thr Asn Leu Leu Ala Ala Glu Thr 
1               5                   10                  15      


Ala Ser Leu Glu Glu Gln Leu Gln Gly Trp Gly Glu Val Met Leu Met 
            20                  25                  30          


Ala Asp Lys Val Leu Arg Trp Glu Arg Ala Trp Phe Pro Pro Ala Ile 
        35                  40                  45              


Met Gly Val Val Ser Leu Val Phe Leu Ile Ile Tyr Tyr Leu Asp Pro 
    50                  55                  60                  


Ser Val Leu Ser Gly Val Ser Cys Phe Val Met Phe Leu Cys Leu Ala 
65                  70                  75                  80  


Asp Tyr Leu Val Pro Ile Leu Ala Pro Arg Ile Phe Gly Ser Asn Lys 
                85                  90                  95      


Trp Thr Thr Glu Gln Gln Gln Arg Phe His Glu Ile Cys Ser Asn Leu 
            100                 105                 110         


Val Lys Thr Arg Arg Arg Ala Val Gly Trp Trp Lys Arg Leu Phe Thr 
        115                 120                 125             


Leu Lys Glu Glu Lys Pro Lys Met Tyr Phe Met Thr Met Ile Val Ser 
    130                 135                 140                 


Leu Ala Ala Val Ala Trp Val Gly Gln Gln Val His Asn Leu Leu Leu 
145                 150                 155                 160 


Thr Tyr Leu Ile Val Thr Ser Leu Leu Leu Leu Pro Gly Leu Asn Gln 
                165                 170                 175     


His Gly Ile Ile Leu Lys Tyr Ile Gly Met Ala Lys Arg Glu Ile Asn 
            180                 185                 190         


Lys Leu Leu Lys Gln Lys Glu Lys Lys Asn Glu 
        195                 200             


<210>  3382
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3382
gccatgtcgt gtcggggaag gtaatgagcc gcagagcccc ggggtctcgg ctgagcagcg     60

gcggcggcgg cggcggcacc aagtatccgc ggagctggaa tgactggcaa cccagaactg    120

atagtgcatc agccgaccca gataatttaa aatattcttc atccagagat agaggtggtt    180

cttcctctta tggactgcaa ccttcaaatt cagctgtggt gtctcggcaa aggcacgatg    240

ataccagagt ccacgctgac atacagaatg acgaaaaggg tggctacagt gtcaatggag    300

gatctgggga aaatacttat ggtcggaagt cgttggggca agagctgagg gttaacaatg    360

tgaccagccc tgagttcacc agtgttcagc atggcagtcg tgctttagcc accaaagaca    420

tgaggaaatc acaggagaga tcgatgtctt attctgatga gtctcgactg tcgaatcttc    480

ttcggaggat cacccgggaa gacgacagag accgaagatt ggctactgta aagcagttga    540

aagaatttat tcagcaacca gaaaataagc tggtactagt taaacaattg gataatatct    600

tggctgctgt acatgacgtg cttaatgaaa gtagcaaatt gcttcaggag ttgagacagg    660

agggagcttg ctgtcttggc cttctttgtg cttctctgag ctatgaggct gagaagatct    720

tcaagtggat ttttagcaaa tttagctcat ctgcaaaaga tgaagttaaa ctcctctact    780

tatgtgccac ctacaaagca ctagagactg taggagaaaa gaaagccttt tcatctgtaa    840

tgcagcttgt aatgaccagc ctgcagtcta ttcttgaaaa tgtggataca ccagaattgc    900

tttgtaaatg tgttaagtgc attcttttgg tggctcgatg ttaccctcat attttcagca    960

ctaattttag ggatacagtt gatatattag ttggatggca tatagatcat actcagaaac   1020

cttcgctcac gcagcaggta tctgggtggt tgcagagttt ggagccattt tgggtagctg   1080

atcttgcatt ttctactact cttcttggtc agtttctgga agacatggaa gcatatgctg   1140

aggacctcag ccatgtggcc tctggggaat cagtggatga agatgtccct cctccatcag   1200

tgtcattacc aaagctggct gcacttctcc gggtatttag tactgtggtg aggagcattg   1260

gggaacgctt cagcccaatt cggggtcctc caattactga ggcatatgta acagatgttc   1320

tgtacagagt aatgagatgt gtgacggctg caaaccaggt gtttttttct gaggctgtgt   1380

tgacagctgc taatgagtgt gttggtgttt tgctcggcag cttggatcct agcatgacta   1440

tacattgtga catggtcatt acatatggat tagaccaact ggagaattgc cagacttgtg   1500

gtaccgatta tatcatctca gtcttgaatt tactcacgct gattgttgaa cagataaata   1560

cgaaactgcc atcatcattt gtagaaaaac tgtttatacc atcatctaaa ctactattct   1620

tgcgttatca taaagaaaaa gaggttgttg ctgtagccca tgctgtttat caagcagtgc   1680

tcagcttgaa gaatattcct gttttggaga ctgcctataa gttaatattg ggagaaatga   1740

cttgtgccct aaacaacctc ctacacagtc tacaacttcc tgaggcctgt tctgaaataa   1800

aacatgaggc ttttaagaat catgtgttca atgtagacaa tgcaaaattt gtagttatat   1860

ttgacctcag tgccctgact acaattggaa atgccaaaaa ctcactaata gggatgtggg   1920

cgctatctcc aactgtcttt gcacttctga gtaagaatct gatgattgtg cacagtgacc   1980

tggctgttca cttccctgcc attcagtatg ctgtgctcta cacattgtat tctcattgta   2040

ccaggcatga tcactttatc tctagtagcc tcagttcttc ctctccttct ttgtttgatg   2100

gagctgtgat tagcactgta actacggcta caaagaaaca tttctcaatt atattaaatc   2160

ttctgggaat attacttaag aaagataacc ttaaccagga cacgaggaaa ctgttaatga   2220

cttgggcttt ggaagcagct gttttaatga agaagtctga aacatacgca cctttattct   2280

ctcttccgtc tttccataaa ttttgcaaag gccttttagc caacactctc gttgaagatg   2340

tgaatatctg tctgcaggca tgcagcagtc tacatgctct gtcctcttcc ttgccagatg   2400

atcttttaca gagatgtgtc gatgtttgcc gtgttcaact agtgcacagt ggaactcgta   2460

ttcgacaagc atttggaaaa ctgttgaaat caattccttt agatgttgtc ctaagcaata   2520

acaatcacac agaaattcaa gaaatttctt tagcattaag aagtcacatg agtaaagcac   2580

caagtaatac attccacccc caagatttct ctgatgttat tagttttatt ttgtatggga   2640

actctcatag aacagggaag gacaattggt tggaaagact gttctatagc tgccagagac   2700

tggataagcg tgaccagtca acaattccac gcaatctcct gaagacagat gctgtccttt   2760

ggcagtgggc catatgggaa gctgcacaat tcactgttct ttctaagctg agaaccccac   2820

tgggcagagc tcaagacacc ttccagacaa ttgaaggtat cattcgaagt ctcgcagctc   2880

acacattaaa ccctgatcag gatgttagtc agtggacaac tgcagacaat gatgaaggcc   2940

atggtaacaa ccaacttaga cttgttcttc ttctgcagta tctggaaaat ctggagaaat   3000

taatgtataa tgcatacgag ggatgtgcta atgcattaac ttcacctccc aaggtcatta   3060

gaactttttt ctataccaat cgccaaactt gtcaggactg gctaacgcgg attcgactct   3120

ccatcatgag ggtaggattg ttggcaggcc agcctgcagt gacagtgaga catggctttg   3180

acttgcttac agagatgaaa acaaccagcc tatctcaggg gaatgaattg gaagtaacca   3240

ttatgatggt ggtagaagca ttatgtgaac ttcattgtcc tgaagctata cagggaattg   3300

ctgtctggtc atcatctatt gttggaaaaa atcttctgtg gattaactca gtggctcaac   3360

aggctgaagg gaggtttgaa aaggcctctg tggagtacca ggaacacctg tgtgccatga   3420

caggtgttga ttgctgcatc tccagctttg acaaatcggt gctcacctta gccaatgctg   3480

ggcgtaacag tgccagcccg aaacattctc tgaatggtga atccagaaaa actgtgctgt   3540

ccaaaccgac tgactcttcc cctgaggtta taaattattt aggaaataaa gcatgtgagt   3600

gctacatctc aattgccgat tgggctgctg tgcaggaatg gcagaacgct atccatgact   3660

tgaaaaagag taccagtagc acttccctca acctgaaagc tgacttcaac tatataaaat   3720

cattaagcag ctttgagtct ggaaaatttg ttgaatgtac cgagcagtta gaattgttac   3780

caggagaaaa tatcaatcta cttgctggag gatcaaaaga aaaaatagac atgaaaaaac   3840

tgcttcctaa catgttaagt ccggatccga gggaacttca gaaatccatt gaagttcaat   3900

tgttaagaag ttctgtttgt ttggcaactg ctttaaaccc gatagaacaa gatcagaagt   3960

ggcagtctat aactgaaaat gtggtaaagt acttgaagca aacatcccgc atcgctattg   4020

gacctctgag actttctact ttaacagttt cacagtcttt gccagttcta agtaccttgc   4080

agctgtattg ctcatctgct ttggagaaca cagtttctaa cagactttca acagaggact   4140

gtcttattcc actcttcagt gaagctttac gttcatgtaa acagcatgac gtgaggccat   4200

ggatgcaggc attaaggtat actatgtacc agaatcagtt gttggagaaa attaaagaac   4260

aaacagtccc aattagaagc catctcatgg aattaggtct aacagcagca aaatttgcta   4320

gaaaacgagg gaatgtgtcc cttgcaacaa gactgctggc acagtgcagt gaagttcagc   4380

tgggaaagac caccactgca caggatttag tccaacattt taaaaaacta tcaacccaag   4440

gtcaagtgga tgaaaaatgg gggcccgaac ttgatattga aaaaaccaaa ttgctttata   4500

cagcaggcca gtcaacacat gcaatggaaa tgttgagttc ttgtgccata tctttctgca   4560

agtctgtgaa agctgaatat gcagttgcta aatcaattct gacactggct aaatggatcc   4620

aggcagaatg gaaagagatt tcaggacagc tgaaacaggt ttacagagct cagcaccaac   4680

agaacttcac aggtctttct actttgtcta aaaacatact cactctaata gaactgccat   4740

ctgttaatac gatggaagaa gagtatcctc ggatcgagag tgaatctaca gtgcatattg   4800

gagttggaga acctgacttc attttgggac agttgtatca cctgtcttca gtacaggcac   4860

ctgaagtagc caaatcttgg gcagcgttgg ccagctgggc ttataggtgg ggcagaaagg   4920

tggttgacaa tgccagtcag ggagaaggtg ttcgtctgct gcctagagaa aaatctgaag   4980

ttcagaatct acttccagac actataactg aggaagagaa agagagaata tatggtattc   5040

ttggacaggc tgtgtgtcgg ccggcgggga ttcaggatga agatataaca cttcagataa   5100

ctgagagtga agacaacgaa gaagatgaca tggttgatgt tatctggcgt cagttgatat   5160

caagctgccc atggctttca gaacttgatg aaagtgcaac tgaaggagtt attaaagtgt   5220

ggaggaaagt tgtagataga atattcagcc tgtacaaact ctcttgcagt gcatacttta   5280

ctttccttaa actcaacgct ggtcaaattc ctttagatga ggatgaccct aggctgcatt   5340

taagtcacag agtggaacag agcactgatg acatgattgt gatggccaca ttgcgcctgc   5400

tgcggttgct cgtgaagcat gctggtgagc ttcggcagta tctggagcac ggcttggaga   5460

caacacccac tgcaccatgg agaggaatta ttccgcaact tttctcacgc ttaaaccacc   5520

ctgaagtgta tgtgcgccaa agtatttgta accttctctg ccgtgtggct caagattccc   5580

cacatctcat attgtatcct gcaatagtgg gtaccatatc gcttagtagt gaatcccagg   5640

cttcaggaaa taaattttcc actgcaattc caactttact tggcaatatt caaggagaag   5700

aattgctggt ttctgaatgt gagggaggaa gtcctcctgc atctcaggat agcaataagg   5760

atgaacctaa aagtggatta aatgaagacc aagccatgat gcaggattgt tacagcaaaa   5820

ttgtagataa gctgtcctct gcaaacccca ccatggtatt acaggttcag atgctcgtgg   5880

ctgaactgcg cagggtcact gtgctctggg atgagctctg gctgggagtt ttgctgcaac   5940

aacacatgta tgtcctgaga cgaattcagc agcttgaaga tgaggtgaag agagtccaga   6000

acaacaacac cttacgcaaa gaagagaaaa ttgcaatcat gagggagaag cacacagctt   6060

tgatgaagcc catcgtattt gctttggagc atgtgaggag tatcacagcg gctcctgcag   6120

aaacacctca tgaaaaatgg tttcaggata actatggtga tgccattgaa aatgccctag   6180

aaaaactgaa gactccattg aaccctgcaa agcctgggag cagctggatt ccatttaaag   6240

agataatgct aagtttgcaa cagagagcac agaaacgtgc aagttacatc ttgcgtcttg   6300

aagaaatcag tccatggttg gctgccatga ctaacactga aattgctctt cctggggaag   6360

tctcagccag agacactgtc acaatccata gtgtgggcgg aaccatcaca atcttaccga   6420

ctaaaaccaa gccaaagaaa cttctctttc ttggatcaga tgggaagagc tatccttatc   6480

ttttcaaagg actggaggat ttacatctgg atgagagaat aatgcagttc ctatctattg   6540

tgaataccat gtttgctaca attaatcgcc aagaaacacc ccggttccat gctcgacact   6600

attctgtaac accactagga acaagatcag gactaatcca gtgggtagat ggagccacac   6660

ccttatttgg tctttacaaa cgatggcaac aacgggaagc tgccttacaa gcacaaaagg   6720

cccaagattc ctaccaaact cctcagaatc ctggaattgt accccgtcct agtgaacttt   6780

attacagtaa aattggccct gctttgaaaa cagttgggct tagcctggat gtgtcccgtc   6840

gggattggcc tcttcatgta atgaaggcag tattggaaga gttaatggag gccacacccc   6900

cgaatctcct tgccaaagag ctctggtcat cttgcacaac acctgatgaa tggtggagag   6960

ttacgcagtc ttatgcaaga tctactgcag tcatgtctat ggttggatac ataattggcc   7020

ttggagacag acatctggat aatgttctta tagatatgac gactggagaa gttgttcaca   7080

tagattacaa tgtttgcttt gaaaaaggta aaagccttag agttcctgag aaagtacctt   7140

ttcgaatgac acaaaacatt gaaacagcac tgggtgtaac tggagtagaa ggtgtattta   7200

ggctttcatg tgagcaggtt ttacacatta tgcggcgtgg cagagagacc ctgctgacgc   7260

tgctggaggc ctttgtgtac gaccctctgg tggactggac agcaggaggc gaggctgggt   7320

ttgctggtgc tgtctatggt ggaggtggcc agcaggccga gagcaagcag agcaagagag   7380

agatggagcg agagatcacc cgcagcctgt tttcttctag agtagctgag attaaggtga   7440

actggtttaa gaatagagat gagatgctgg ttgtgcttcc caagttggac ggtagcttag   7500

atgaatacct aagcttgcaa gagcaactga cagatgtgga aaaactgcag ggcaaactac   7560

tggaggaaat agagtttcta gaaggagctg aaggggtgga tcatccttct catactctgc   7620

aacacaggta ttctgagcac acccaactac agactcagca aagagctgtt caggaagcaa   7680

tccaggtgaa gctgaatgaa tttgaacaat ggataacaca ttatcaggct gcattcaata   7740

atttagaagc aacacagctt gcaagcttgc ttcaagagat aagcacacaa atggaccttg   7800

gtcctccaag ttacgtgcca gcaacagcct ttctgcagaa tgctggtcag gcccacttga   7860

ttagccagtg cgagcagctg gagggggagg ttggtgctct cctgcagcag aggcgctccg   7920

tgctccgtgg ctgtctggag caactgcatc actatgcaac cgtggccctg cagtatccga   7980

aggccatatt tcagaaacat cgaattgaac agtggaagac ctggatggaa gagctcatct   8040

gtaacaccac agtagagcgt tgtcaagagc tctataggaa atatgaaatg caatatgctc   8100

cccagccacc cccaacagtg tgtcagttca tcactgccac tgaaatgacc ctgcagcgat   8160

acgcagcaga catcaacagc agacttatta ga                                 8192


<210>  3383
<211>  3661
<212>  PRT
<213>  Homosapiens

<400>  3383

Met Ser Arg Arg Ala Pro Gly Ser Arg Leu Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Thr Lys Tyr Pro Arg Ser Trp Asn Asp Trp Gln Pro Arg Thr 
            20                  25                  30          


Asp Ser Ala Ser Ala Asp Pro Asp Asn Leu Lys Tyr Ser Ser Ser Arg 
        35                  40                  45              


Asp Arg Gly Gly Ser Ser Ser Tyr Gly Leu Gln Pro Ser Asn Ser Ala 
    50                  55                  60                  


Val Val Ser Arg Gln Arg His Asp Asp Thr Arg Val His Ala Asp Ile 
65                  70                  75                  80  


Gln Asn Asp Glu Lys Gly Gly Tyr Ser Val Asn Gly Gly Ser Gly Glu 
                85                  90                  95      


Asn Thr Tyr Gly Arg Lys Ser Leu Gly Gln Glu Leu Arg Val Asn Asn 
            100                 105                 110         


Val Thr Ser Pro Glu Phe Thr Ser Val Gln His Gly Ser Arg Ala Leu 
        115                 120                 125             


Ala Thr Lys Asp Met Arg Lys Ser Gln Glu Arg Ser Met Ser Tyr Ser 
    130                 135                 140                 


Asp Glu Ser Arg Leu Ser Asn Leu Leu Arg Arg Ile Thr Arg Glu Asp 
145                 150                 155                 160 


Asp Arg Asp Arg Arg Leu Ala Thr Val Lys Gln Leu Lys Glu Phe Ile 
                165                 170                 175     


Gln Gln Pro Glu Asn Lys Leu Val Leu Val Lys Gln Leu Asp Asn Ile 
            180                 185                 190         


Leu Ala Ala Val His Asp Val Leu Asn Glu Ser Ser Lys Leu Leu Gln 
        195                 200                 205             


Glu Leu Arg Gln Glu Gly Ala Cys Cys Leu Gly Leu Leu Cys Ala Ser 
    210                 215                 220                 


Leu Ser Tyr Glu Ala Glu Lys Ile Phe Lys Trp Ile Phe Ser Lys Phe 
225                 230                 235                 240 


Ser Ser Ser Ala Lys Asp Glu Val Lys Leu Leu Tyr Leu Cys Ala Thr 
                245                 250                 255     


Tyr Lys Ala Leu Glu Thr Val Gly Glu Lys Lys Ala Phe Ser Ser Val 
            260                 265                 270         


Met Gln Leu Val Met Thr Ser Leu Gln Ser Ile Leu Glu Asn Val Asp 
        275                 280                 285             


Thr Pro Glu Leu Leu Cys Lys Cys Val Lys Cys Ile Leu Leu Val Ala 
    290                 295                 300                 


Arg Cys Tyr Pro His Ile Phe Ser Thr Asn Phe Arg Asp Thr Val Asp 
305                 310                 315                 320 


Ile Leu Val Gly Trp His Ile Asp His Thr Gln Lys Pro Ser Leu Thr 
                325                 330                 335     


Gln Gln Val Ser Gly Trp Leu Gln Ser Leu Glu Pro Phe Trp Val Ala 
            340                 345                 350         


Asp Leu Ala Phe Ser Thr Thr Leu Leu Gly Gln Phe Leu Glu Asp Met 
        355                 360                 365             


Glu Ala Tyr Ala Glu Asp Leu Ser His Val Ala Ser Gly Glu Ser Val 
    370                 375                 380                 


Asp Glu Asp Val Pro Pro Pro Ser Val Ser Leu Pro Lys Leu Ala Ala 
385                 390                 395                 400 


Leu Leu Arg Val Phe Ser Thr Val Val Arg Ser Ile Gly Glu Arg Phe 
                405                 410                 415     


Ser Pro Ile Arg Gly Pro Pro Ile Thr Glu Ala Tyr Val Thr Asp Val 
            420                 425                 430         


Leu Tyr Arg Val Met Arg Cys Val Thr Ala Ala Asn Gln Val Phe Phe 
        435                 440                 445             


Ser Glu Ala Val Leu Thr Ala Ala Asn Glu Cys Val Gly Val Leu Leu 
    450                 455                 460                 


Gly Ser Leu Asp Pro Ser Met Thr Ile His Cys Asp Met Val Ile Thr 
465                 470                 475                 480 


Tyr Gly Leu Asp Gln Leu Glu Asn Cys Gln Thr Cys Gly Thr Asp Tyr 
                485                 490                 495     


Ile Ile Ser Val Leu Asn Leu Leu Thr Leu Ile Val Glu Gln Ile Asn 
            500                 505                 510         


Thr Lys Leu Pro Ser Ser Phe Val Glu Lys Leu Phe Ile Pro Ser Ser 
        515                 520                 525             


Lys Leu Leu Phe Leu Arg Tyr His Lys Glu Lys Glu Val Val Ala Val 
    530                 535                 540                 


Ala His Ala Val Tyr Gln Ala Val Leu Ser Leu Lys Asn Ile Pro Val 
545                 550                 555                 560 


Leu Glu Thr Ala Tyr Lys Leu Ile Leu Gly Glu Met Thr Cys Ala Leu 
                565                 570                 575     


Asn Asn Leu Leu His Ser Leu Gln Leu Pro Glu Ala Cys Ser Glu Ile 
            580                 585                 590         


Lys His Glu Ala Phe Lys Asn His Val Phe Asn Val Asp Asn Ala Lys 
        595                 600                 605             


Phe Val Val Ile Phe Asp Leu Ser Ala Leu Thr Thr Ile Gly Asn Ala 
    610                 615                 620                 


Lys Asn Ser Leu Ile Gly Met Trp Ala Leu Ser Pro Thr Val Phe Ala 
625                 630                 635                 640 


Leu Leu Ser Lys Asn Leu Met Ile Val His Ser Asp Leu Ala Val His 
                645                 650                 655     


Phe Pro Ala Ile Gln Tyr Ala Val Leu Tyr Thr Leu Tyr Ser His Cys 
            660                 665                 670         


Thr Arg His Asp His Phe Ile Ser Ser Ser Leu Ser Ser Ser Ser Pro 
        675                 680                 685             


Ser Leu Phe Asp Gly Ala Val Ile Ser Thr Val Thr Thr Ala Thr Lys 
    690                 695                 700                 


Lys His Phe Ser Ile Ile Leu Asn Leu Leu Gly Ile Leu Leu Lys Lys 
705                 710                 715                 720 


Asp Asn Leu Asn Gln Asp Thr Arg Lys Leu Leu Met Thr Trp Ala Leu 
                725                 730                 735     


Glu Ala Ala Val Leu Met Lys Lys Ser Glu Thr Tyr Ala Pro Leu Phe 
            740                 745                 750         


Ser Leu Pro Ser Phe His Lys Phe Cys Lys Gly Leu Leu Ala Asn Thr 
        755                 760                 765             


Leu Val Glu Asp Val Asn Ile Cys Leu Gln Ala Cys Ser Ser Leu His 
    770                 775                 780                 


Ala Leu Ser Ser Ser Leu Pro Asp Asp Leu Leu Gln Arg Cys Val Asp 
785                 790                 795                 800 


Val Cys Arg Val Gln Leu Val His Ser Gly Thr Arg Ile Arg Gln Ala 
                805                 810                 815     


Phe Gly Lys Leu Leu Lys Ser Ile Pro Leu Asp Val Val Leu Ser Asn 
            820                 825                 830         


Asn Asn His Thr Glu Ile Gln Glu Ile Ser Leu Ala Leu Arg Ser His 
        835                 840                 845             


Met Ser Lys Ala Pro Ser Asn Thr Phe His Pro Gln Asp Phe Ser Asp 
    850                 855                 860                 


Val Ile Ser Phe Ile Leu Tyr Gly Asn Ser His Arg Thr Gly Lys Asp 
865                 870                 875                 880 


Asn Trp Leu Glu Arg Leu Phe Tyr Ser Cys Gln Arg Leu Asp Lys Arg 
                885                 890                 895     


Asp Gln Ser Thr Ile Pro Arg Asn Leu Leu Lys Thr Asp Ala Val Leu 
            900                 905                 910         


Trp Gln Trp Ala Ile Trp Glu Ala Ala Gln Phe Thr Val Leu Ser Lys 
        915                 920                 925             


Leu Arg Thr Pro Leu Gly Arg Ala Gln Asp Thr Phe Gln Thr Ile Glu 
    930                 935                 940                 


Gly Ile Ile Arg Ser Leu Ala Ala His Thr Leu Asn Pro Asp Gln Asp 
945                 950                 955                 960 


Val Ser Gln Trp Thr Thr Ala Asp Asn Asp Glu Gly His Gly Asn Asn 
                965                 970                 975     


Gln Leu Arg Leu Val Leu Leu Leu Gln Tyr Leu Glu Asn Leu Glu Lys 
            980                 985                 990         


Leu Met Tyr Asn Ala Tyr Glu Gly  Cys Ala Asn Ala Leu  Thr Ser Pro 
        995                 1000                 1005             


Pro Lys  Val Ile Arg Thr Phe  Phe Tyr Thr Asn Arg  Gln Thr Cys 
    1010                 1015                 1020             


Gln Asp  Trp Leu Thr Arg Ile  Arg Leu Ser Ile Met  Arg Val Gly 
    1025                 1030                 1035             


Leu Leu  Ala Gly Gln Pro Ala  Val Thr Val Arg His  Gly Phe Asp 
    1040                 1045                 1050             


Leu Leu  Thr Glu Met Lys Thr  Thr Ser Leu Ser Gln  Gly Asn Glu 
    1055                 1060                 1065             


Leu Glu  Val Thr Ile Met Met  Val Val Glu Ala Leu  Cys Glu Leu 
    1070                 1075                 1080             


His Cys  Pro Glu Ala Ile Gln  Gly Ile Ala Val Trp  Ser Ser Ser 
    1085                 1090                 1095             


Ile Val  Gly Lys Asn Leu Leu  Trp Ile Asn Ser Val  Ala Gln Gln 
    1100                 1105                 1110             


Ala Glu  Gly Arg Phe Glu Lys  Ala Ser Val Glu Tyr  Gln Glu His 
    1115                 1120                 1125             


Leu Cys  Ala Met Thr Gly Val  Asp Cys Cys Ile Ser  Ser Phe Asp 
    1130                 1135                 1140             


Lys Ser  Val Leu Thr Leu Ala  Asn Ala Gly Arg Asn  Ser Ala Ser 
    1145                 1150                 1155             


Pro Lys  His Ser Leu Asn Gly  Glu Ser Arg Lys Thr  Val Leu Ser 
    1160                 1165                 1170             


Lys Pro  Thr Asp Ser Ser Pro  Glu Val Ile Asn Tyr  Leu Gly Asn 
    1175                 1180                 1185             


Lys Ala  Cys Glu Cys Tyr Ile  Ser Ile Ala Asp Trp  Ala Ala Val 
    1190                 1195                 1200             


Gln Glu  Trp Gln Asn Ala Ile  His Asp Leu Lys Lys  Ser Thr Ser 
    1205                 1210                 1215             


Ser Thr  Ser Leu Asn Leu Lys  Ala Asp Phe Asn Tyr  Ile Lys Ser 
    1220                 1225                 1230             


Leu Ser  Ser Phe Glu Ser Gly  Lys Phe Val Glu Cys  Thr Glu Gln 
    1235                 1240                 1245             


Leu Glu  Leu Leu Pro Gly Glu  Asn Ile Asn Leu Leu  Ala Gly Gly 
    1250                 1255                 1260             


Ser Lys  Glu Lys Ile Asp Met  Lys Lys Leu Leu Pro  Asn Met Leu 
    1265                 1270                 1275             


Ser Pro  Asp Pro Arg Glu Leu  Gln Lys Ser Ile Glu  Val Gln Leu 
    1280                 1285                 1290             


Leu Arg  Ser Ser Val Cys Leu  Ala Thr Ala Leu Asn  Pro Ile Glu 
    1295                 1300                 1305             


Gln Asp  Gln Lys Trp Gln Ser  Ile Thr Glu Asn Val  Val Lys Tyr 
    1310                 1315                 1320             


Leu Lys  Gln Thr Ser Arg Ile  Ala Ile Gly Pro Leu  Arg Leu Ser 
    1325                 1330                 1335             


Thr Leu  Thr Val Ser Gln Ser  Leu Pro Val Leu Ser  Thr Leu Gln 
    1340                 1345                 1350             


Leu Tyr  Cys Ser Ser Ala Leu  Glu Asn Thr Val Ser  Asn Arg Leu 
    1355                 1360                 1365             


Ser Thr  Glu Asp Cys Leu Ile  Pro Leu Phe Ser Glu  Ala Leu Arg 
    1370                 1375                 1380             


Ser Cys  Lys Gln His Asp Val  Arg Pro Trp Met Gln  Ala Leu Arg 
    1385                 1390                 1395             


Tyr Thr  Met Tyr Gln Asn Gln  Leu Leu Glu Lys Ile  Lys Glu Gln 
    1400                 1405                 1410             


Thr Val  Pro Ile Arg Ser His  Leu Met Glu Leu Gly  Leu Thr Ala 
    1415                 1420                 1425             


Ala Lys  Phe Ala Arg Lys Arg  Gly Asn Val Ser Leu  Ala Thr Arg 
    1430                 1435                 1440             


Leu Leu  Ala Gln Cys Ser Glu  Val Gln Leu Gly Lys  Thr Thr Thr 
    1445                 1450                 1455             


Ala Gln  Asp Leu Val Gln His  Phe Lys Lys Leu Ser  Thr Gln Gly 
    1460                 1465                 1470             


Gln Val  Asp Glu Lys Trp Gly  Pro Glu Leu Asp Ile  Glu Lys Thr 
    1475                 1480                 1485             


Lys Leu  Leu Tyr Thr Ala Gly  Gln Ser Thr His Ala  Met Glu Met 
    1490                 1495                 1500             


Leu Ser  Ser Cys Ala Ile Ser  Phe Cys Lys Ser Val  Lys Ala Glu 
    1505                 1510                 1515             


Tyr Ala  Val Ala Lys Ser Ile  Leu Thr Leu Ala Lys  Trp Ile Gln 
    1520                 1525                 1530             


Ala Glu  Trp Lys Glu Ile Ser  Gly Gln Leu Lys Gln  Val Tyr Arg 
    1535                 1540                 1545             


Ala Gln  His Gln Gln Asn Phe  Thr Gly Leu Ser Thr  Leu Ser Lys 
    1550                 1555                 1560             


Asn Ile  Leu Thr Leu Ile Glu  Leu Pro Ser Val Asn  Thr Met Glu 
    1565                 1570                 1575             


Glu Glu  Tyr Pro Arg Ile Glu  Ser Glu Ser Thr Val  His Ile Gly 
    1580                 1585                 1590             


Val Gly  Glu Pro Asp Phe Ile  Leu Gly Gln Leu Tyr  His Leu Ser 
    1595                 1600                 1605             


Ser Val  Gln Ala Pro Glu Val  Ala Lys Ser Trp Ala  Ala Leu Ala 
    1610                 1615                 1620             


Ser Trp  Ala Tyr Arg Trp Gly  Arg Lys Val Val Asp  Asn Ala Ser 
    1625                 1630                 1635             


Gln Gly  Glu Gly Val Arg Leu  Leu Pro Arg Glu Lys  Ser Glu Val 
    1640                 1645                 1650             


Gln Asn  Leu Leu Pro Asp Thr  Ile Thr Glu Glu Glu  Lys Glu Arg 
    1655                 1660                 1665             


Ile Tyr  Gly Ile Leu Gly Gln  Ala Val Cys Arg Pro  Ala Gly Ile 
    1670                 1675                 1680             


Gln Asp  Glu Asp Ile Thr Leu  Gln Ile Thr Glu Ser  Glu Asp Asn 
    1685                 1690                 1695             


Glu Glu  Asp Asp Met Val Asp  Val Ile Trp Arg Gln  Leu Ile Ser 
    1700                 1705                 1710             


Ser Cys  Pro Trp Leu Ser Glu  Leu Asp Glu Ser Ala  Thr Glu Gly 
    1715                 1720                 1725             


Val Ile  Lys Val Trp Arg Lys  Val Val Asp Arg Ile  Phe Ser Leu 
    1730                 1735                 1740             


Tyr Lys  Leu Ser Cys Ser Ala  Tyr Phe Thr Phe Leu  Lys Leu Asn 
    1745                 1750                 1755             


Ala Gly  Gln Ile Pro Leu Asp  Glu Asp Asp Pro Arg  Leu His Leu 
    1760                 1765                 1770             


Ser His  Arg Val Glu Gln Ser  Thr Asp Asp Met Ile  Val Met Ala 
    1775                 1780                 1785             


Thr Leu  Arg Leu Leu Arg Leu  Leu Val Lys His Ala  Gly Glu Leu 
    1790                 1795                 1800             


Arg Gln  Tyr Leu Glu His Gly  Leu Glu Thr Thr Pro  Thr Ala Pro 
    1805                 1810                 1815             


Trp Arg  Gly Ile Ile Pro Gln  Leu Phe Ser Arg Leu  Asn His Pro 
    1820                 1825                 1830             


Glu Val  Tyr Val Arg Gln Ser  Ile Cys Asn Leu Leu  Cys Arg Val 
    1835                 1840                 1845             


Ala Gln  Asp Ser Pro His Leu  Ile Leu Tyr Pro Ala  Ile Val Gly 
    1850                 1855                 1860             


Thr Ile  Ser Leu Ser Ser Glu  Ser Gln Ala Ser Gly  Asn Lys Phe 
    1865                 1870                 1875             


Ser Thr  Ala Ile Pro Thr Leu  Leu Gly Asn Ile Gln  Gly Glu Glu 
    1880                 1885                 1890             


Leu Leu  Val Ser Glu Cys Glu  Gly Gly Ser Pro Pro  Ala Ser Gln 
    1895                 1900                 1905             


Asp Ser  Asn Lys Asp Glu Pro  Lys Ser Gly Leu Asn  Glu Asp Gln 
    1910                 1915                 1920             


Ala Met  Met Gln Asp Cys Tyr  Ser Lys Ile Val Asp  Lys Leu Ser 
    1925                 1930                 1935             


Ser Ala  Asn Pro Thr Met Val  Leu Gln Val Gln Met  Leu Val Ala 
    1940                 1945                 1950             


Glu Leu  Arg Arg Val Thr Val  Leu Trp Asp Glu Leu  Trp Leu Gly 
    1955                 1960                 1965             


Val Leu  Leu Gln Gln His Met  Tyr Val Leu Arg Arg  Ile Gln Gln 
    1970                 1975                 1980             


Leu Glu  Asp Glu Val Lys Arg  Val Gln Asn Asn Asn  Thr Leu Arg 
    1985                 1990                 1995             


Lys Glu  Glu Lys Ile Ala Ile  Met Arg Glu Lys His  Thr Ala Leu 
    2000                 2005                 2010             


Met Lys  Pro Ile Val Phe Ala  Leu Glu His Val Arg  Ser Ile Thr 
    2015                 2020                 2025             


Ala Ala  Pro Ala Glu Thr Pro  His Glu Lys Trp Phe  Gln Asp Asn 
    2030                 2035                 2040             


Tyr Gly  Asp Ala Ile Glu Asn  Ala Leu Glu Lys Leu  Lys Thr Pro 
    2045                 2050                 2055             


Leu Asn  Pro Ala Lys Pro Gly  Ser Ser Trp Ile Pro  Phe Lys Glu 
    2060                 2065                 2070             


Ile Met  Leu Ser Leu Gln Gln  Arg Ala Gln Lys Arg  Ala Ser Tyr 
    2075                 2080                 2085             


Ile Leu  Arg Leu Glu Glu Ile  Ser Pro Trp Leu Ala  Ala Met Thr 
    2090                 2095                 2100             


Asn Thr  Glu Ile Ala Leu Pro  Gly Glu Val Ser Ala  Arg Asp Thr 
    2105                 2110                 2115             


Val Thr  Ile His Ser Val Gly  Gly Thr Ile Thr Ile  Leu Pro Thr 
    2120                 2125                 2130             


Lys Thr  Lys Pro Lys Lys Leu  Leu Phe Leu Gly Ser  Asp Gly Lys 
    2135                 2140                 2145             


Ser Tyr  Pro Tyr Leu Phe Lys  Gly Leu Glu Asp Leu  His Leu Asp 
    2150                 2155                 2160             


Glu Arg  Ile Met Gln Phe Leu  Ser Ile Val Asn Thr  Met Phe Ala 
    2165                 2170                 2175             


Thr Ile  Asn Arg Gln Glu Thr  Pro Arg Phe His Ala  Arg His Tyr 
    2180                 2185                 2190             


Ser Val  Thr Pro Leu Gly Thr  Arg Ser Gly Leu Ile  Gln Trp Val 
    2195                 2200                 2205             


Asp Gly  Ala Thr Pro Leu Phe  Gly Leu Tyr Lys Arg  Trp Gln Gln 
    2210                 2215                 2220             


Arg Glu  Ala Ala Leu Gln Ala  Gln Lys Ala Gln Asp  Ser Tyr Gln 
    2225                 2230                 2235             


Thr Pro  Gln Asn Pro Gly Ile  Val Pro Arg Pro Ser  Glu Leu Tyr 
    2240                 2245                 2250             


Tyr Ser  Lys Ile Gly Pro Ala  Leu Lys Thr Val Gly  Leu Ser Leu 
    2255                 2260                 2265             


Asp Val  Ser Arg Arg Asp Trp  Pro Leu His Val Met  Lys Ala Val 
    2270                 2275                 2280             


Leu Glu  Glu Leu Met Glu Ala  Thr Pro Pro Asn Leu  Leu Ala Lys 
    2285                 2290                 2295             


Glu Leu  Trp Ser Ser Cys Thr  Thr Pro Asp Glu Trp  Trp Arg Val 
    2300                 2305                 2310             


Thr Gln  Ser Tyr Ala Arg Ser  Thr Ala Val Met Ser  Met Val Gly 
    2315                 2320                 2325             


Tyr Ile  Ile Gly Leu Gly Asp  Arg His Leu Asp Asn  Val Leu Ile 
    2330                 2335                 2340             


Asp Met  Thr Thr Gly Glu Val  Val His Ile Asp Tyr  Asn Val Cys 
    2345                 2350                 2355             


Phe Glu  Lys Gly Lys Ser Leu  Arg Val Pro Glu Lys  Val Pro Phe 
    2360                 2365                 2370             


Arg Met  Thr Gln Asn Ile Glu  Thr Ala Leu Gly Val  Thr Gly Val 
    2375                 2380                 2385             


Glu Gly  Val Phe Arg Leu Ser  Cys Glu Gln Val Leu  His Ile Met 
    2390                 2395                 2400             


Arg Arg  Gly Arg Glu Thr Leu  Leu Thr Leu Leu Glu  Ala Phe Val 
    2405                 2410                 2415             


Tyr Asp  Pro Leu Val Asp Trp  Thr Ala Gly Gly Glu  Ala Gly Phe 
    2420                 2425                 2430             


Ala Gly  Ala Val Tyr Gly Gly  Gly Gly Gln Gln Ala  Glu Ser Lys 
    2435                 2440                 2445             


Gln Ser  Lys Arg Glu Met Glu  Arg Glu Ile Thr Arg  Ser Leu Phe 
    2450                 2455                 2460             


Ser Ser  Arg Val Ala Glu Ile  Lys Val Asn Trp Phe  Lys Asn Arg 
    2465                 2470                 2475             


Asp Glu  Met Leu Val Val Leu  Pro Lys Leu Asp Gly  Ser Leu Asp 
    2480                 2485                 2490             


Glu Tyr  Leu Ser Leu Gln Glu  Gln Leu Thr Asp Val  Glu Lys Leu 
    2495                 2500                 2505             


Gln Gly  Lys Leu Leu Glu Glu  Ile Glu Phe Leu Glu  Gly Ala Glu 
    2510                 2515                 2520             


Gly Val  Asp His Pro Ser His  Thr Leu Gln His Arg  Tyr Ser Glu 
    2525                 2530                 2535             


His Thr  Gln Leu Gln Thr Gln  Gln Arg Ala Val Gln  Glu Ala Ile 
    2540                 2545                 2550             


Gln Val  Lys Leu Asn Glu Phe  Glu Gln Trp Ile Thr  His Tyr Gln 
    2555                 2560                 2565             


Ala Ala  Phe Asn Asn Leu Glu  Ala Thr Gln Leu Ala  Ser Leu Leu 
    2570                 2575                 2580             


Gln Glu  Ile Ser Thr Gln Met  Asp Leu Gly Pro Pro  Ser Tyr Val 
    2585                 2590                 2595             


Pro Ala  Thr Ala Phe Leu Gln  Asn Ala Gly Gln Ala  His Leu Ile 
    2600                 2605                 2610             


Ser Gln  Cys Glu Gln Leu Glu  Gly Glu Val Gly Ala  Leu Leu Gln 
    2615                 2620                 2625             


Gln Arg  Arg Ser Val Leu Arg  Gly Cys Leu Glu Gln  Leu His His 
    2630                 2635                 2640             


Tyr Ala  Thr Val Ala Leu Gln  Tyr Pro Lys Ala Ile  Phe Gln Lys 
    2645                 2650                 2655             


His Arg  Ile Glu Gln Trp Lys  Thr Trp Met Glu Glu  Leu Ile Cys 
    2660                 2665                 2670             


Asn Thr  Thr Val Glu Arg Cys  Gln Glu Leu Tyr Arg  Lys Tyr Glu 
    2675                 2680                 2685             


Met Gln  Tyr Ala Pro Gln Pro  Pro Pro Thr Val Cys  Gln Phe Ile 
    2690                 2695                 2700             


Thr Ala  Thr Glu Met Thr Leu  Gln Arg Tyr Ala Ala  Asp Ile Asn 
    2705                 2710                 2715             


Ser Arg  Leu Ile Arg Gln Val  Glu Arg Leu Lys Gln  Glu Ala Val 
    2720                 2725                 2730             


Thr Val  Pro Val Cys Glu Asp  Gln Leu Lys Glu Ile  Glu Arg Cys 
    2735                 2740                 2745             


Ile Lys  Val Phe Leu His Glu  Asn Gly Glu Glu Gly  Ser Leu Ser 
    2750                 2755                 2760             


Leu Ala  Ser Val Ile Ile Ser  Ala Leu Cys Thr Leu  Thr Arg Arg 
    2765                 2770                 2775             


Asn Leu  Met Met Glu Gly Ala  Ala Ser Ser Ala Gly  Glu Gln Leu 
    2780                 2785                 2790             


Val Asp  Leu Thr Ser Arg Asp  Gly Ala Trp Phe Leu  Glu Glu Leu 
    2795                 2800                 2805             


Cys Ser  Met Ser Gly Asn Val  Thr Cys Leu Val Gln  Leu Leu Lys 
    2810                 2815                 2820             


Gln Cys  His Leu Val Pro Gln  Asp Leu Asp Ile Pro  Asn Pro Met 
    2825                 2830                 2835             


Glu Ala  Ser Glu Thr Val His  Leu Ala Asn Gly Val  Tyr Thr Ser 
    2840                 2845                 2850             


Leu Gln  Glu Leu Asn Ser Asn  Phe Arg Gln Ile Ile  Phe Pro Glu 
    2855                 2860                 2865             


Ala Leu  Arg Cys Leu Met Lys  Gly Glu Tyr Thr Leu  Glu Ser Met 
    2870                 2875                 2880             


Leu His  Glu Leu Asp Gly Leu  Ile Glu Gln Thr Thr  Asp Gly Val 
    2885                 2890                 2895             


Pro Leu  Gln Thr Leu Val Glu  Ser Leu Gln Ala Tyr  Leu Arg Asn 
    2900                 2905                 2910             


Ala Ala  Met Gly Leu Glu Glu  Glu Thr His Ala His  Tyr Ile Asp 
    2915                 2920                 2925             


Val Ala  Arg Leu Leu His Ala  Gln Tyr Gly Glu Leu  Ile Gln Pro 
    2930                 2935                 2940             


Arg Asn  Gly Ser Val Asp Glu  Thr Pro Lys Met Ser  Ala Gly Gln 
    2945                 2950                 2955             


Met Leu  Leu Val Ala Phe Asp  Gly Met Phe Ala Gln  Val Glu Thr 
    2960                 2965                 2970             


Ala Phe  Ser Leu Leu Val Glu  Lys Leu Asn Lys Met  Glu Ile Pro 
    2975                 2980                 2985             


Ile Ala  Trp Arg Lys Ile Asp  Ile Ile Arg Glu Ala  Arg Ser Thr 
    2990                 2995                 3000             


Gln Val  Asn Phe Phe Asp Asp  Asp Asn His Arg Gln  Val Leu Glu 
    3005                 3010                 3015             


Glu Ile  Phe Phe Leu Lys Arg  Leu Gln Thr Ile Lys  Glu Phe Phe 
    3020                 3025                 3030             


Arg Leu  Cys Gly Thr Phe Ser  Lys Thr Leu Ser Gly  Ser Ser Ser 
    3035                 3040                 3045             


Leu Glu  Asp Gln Asn Thr Val  Asn Gly Pro Val Gln  Ile Val Asn 
    3050                 3055                 3060             


Val Lys  Thr Leu Phe Arg Asn  Ser Cys Phe Ser Glu  Asp Gln Met 
    3065                 3070                 3075             


Ala Lys  Pro Ile Lys Ala Phe  Thr Ala Asp Phe Val  Arg Gln Leu 
    3080                 3085                 3090             


Leu Ile  Gly Leu Pro Asn Gln  Ala Leu Gly Leu Thr  Leu Cys Ser 
    3095                 3100                 3105             


Phe Ile  Ser Ala Leu Gly Val  Asp Ile Ile Ala Gln  Val Glu Ala 
    3110                 3115                 3120             


Lys Asp  Phe Gly Ala Glu Ser  Lys Val Ser Val Asp  Asp Leu Cys 
    3125                 3130                 3135             


Lys Lys  Ala Val Glu His Asn  Ile Gln Ile Gly Lys  Phe Ser Gln 
    3140                 3145                 3150             


Leu Val  Met Asn Arg Ala Thr  Val Leu Ala Ser Ser  Tyr Asp Thr 
    3155                 3160                 3165             


Ala Trp  Lys Lys His Asp Leu  Val Arg Arg Leu Glu  Thr Ser Ile 
    3170                 3175                 3180             


Ser Ser  Cys Lys Thr Ser Leu  Gln Arg Val Gln Leu  His Ile Ala 
    3185                 3190                 3195             


Met Phe  Gln Trp Gln His Glu  Asp Leu Leu Ile Asn  Arg Pro Gln 
    3200                 3205                 3210             


Ala Met  Ser Val Thr Pro Pro  Pro Arg Ser Ala Ile  Leu Thr Ser 
    3215                 3220                 3225             


Met Lys  Lys Lys Leu His Thr  Leu Ser Gln Ile Glu  Thr Ser Ile 
    3230                 3235                 3240             


Ala Thr  Val Gln Glu Lys Leu  Ala Ala Leu Glu Ser  Ser Ile Glu 
    3245                 3250                 3255             


Gln Arg  Leu Lys Trp Ala Gly  Gly Ala Asn Pro Ala  Leu Ala Pro 
    3260                 3265                 3270             


Val Leu  Gln Asp Phe Glu Ala  Thr Ile Ala Glu Arg  Arg Asn Leu 
    3275                 3280                 3285             


Val Leu  Lys Glu Ser Gln Arg  Ala Ser Gln Val Thr  Phe Leu Cys 
    3290                 3295                 3300             


Ser Asn  Ile Ile His Phe Glu  Ser Leu Arg Thr Arg  Thr Ala Glu 
    3305                 3310                 3315             


Ala Leu  Asn Leu Asp Ala Ala  Leu Phe Glu Leu Ile  Lys Arg Cys 
    3320                 3325                 3330             


Gln Gln  Met Cys Ser Phe Ala  Ser Gln Phe Asn Ser  Ser Val Ser 
    3335                 3340                 3345             


Glu Leu  Glu Leu Arg Leu Leu  Gln Arg Val Asp Thr  Gly Leu Glu 
    3350                 3355                 3360             


His Pro  Ile Gly Ser Ser Glu  Trp Leu Leu Ser Ala  His Lys Gln 
    3365                 3370                 3375             


Leu Thr  Gln Asp Met Ser Thr  Gln Arg Ala Ile Gln  Thr Glu Lys 
    3380                 3385                 3390             


Glu Gln  Gln Ile Glu Thr Val  Cys Glu Thr Ile Gln  Asn Leu Val 
    3395                 3400                 3405             


Asp Asn  Ile Lys Thr Val Leu  Thr Gly His Asn Arg  Gln Leu Gly 
    3410                 3415                 3420             


Asp Val  Lys His Leu Leu Lys  Ala Met Ala Lys Asp  Glu Glu Ala 
    3425                 3430                 3435             


Ala Leu  Ala Asp Gly Glu Asp  Val Pro Tyr Glu Asn  Ser Val Arg 
    3440                 3445                 3450             


Gln Phe  Leu Gly Glu Tyr Lys  Ser Trp Gln Asp Asn  Ile Gln Thr 
    3455                 3460                 3465             


Val Leu  Phe Thr Leu Val Gln  Ala Met Gly Gln Val  Arg Ser Gln 
    3470                 3475                 3480             


Glu His  Val Glu Met Leu Gln  Glu Ile Thr Pro Thr  Leu Lys Glu 
    3485                 3490                 3495             


Leu Lys  Thr Gln Ser Gln Ser  Ile Tyr Asn Asn Leu  Val Ser Phe 
    3500                 3505                 3510             


Ala Ser  Pro Leu Val Thr Asp  Ala Thr Asn Glu Cys  Ser Ser Pro 
    3515                 3520                 3525             


Thr Ser  Ser Ala Thr Tyr Gln  Pro Ser Phe Ala Ala  Ala Val Arg 
    3530                 3535                 3540             


Ser Asn  Thr Gly Gln Lys Thr  Gln Pro Asp Val Met  Ser Gln Asn 
    3545                 3550                 3555             


Ala Arg  Lys Leu Ile Gln Lys  Asn Leu Ala Thr Ser  Ala Asp Thr 
    3560                 3565                 3570             


Pro Pro  Ser Thr Val Pro Gly  Thr Gly Lys Ser Val  Ala Cys Ser 
    3575                 3580                 3585             


Pro Lys  Lys Ala Val Arg Asp  Pro Lys Thr Gly Lys  Ala Val Gln 
    3590                 3595                 3600             


Glu Arg  Asn Ser Tyr Ala Val  Ser Val Trp Lys Arg  Val Lys Ala 
    3605                 3610                 3615             


Lys Leu  Glu Gly Arg Asp Val  Asp Pro Asn Arg Arg  Met Ser Val 
    3620                 3625                 3630             


Ala Glu  Gln Val Asp Tyr Val  Ile Lys Glu Ala Thr  Asn Leu Asp 
    3635                 3640                 3645             


Asn Leu  Ala Gln Leu Tyr Glu  Gly Trp Thr Ala Trp  Val 
    3650                 3655                 3660     


<210>  3384
<211>  3581
<212>  DNA
<213>  Homosapiens

<400>  3384
gggggcggcg gcggctggag agggtcctcg gcagcctctg aggagcgcgg ggcgcggcca     60

tgagcgagtc cagcggcagt gcgctccagc ccggcaggcc cagccggcag caggcggtcc    120

atccagagaa cctctctcta gactccagtt gcttctcttc tccacctgtg aacttcctcc    180

aagaattgcc aagctaccgg tccattgcac gtaggagaac gactgtccat tcccgggaca    240

agcaaagcgg aactttgcta aagccaaccg actcttacag ctcccagctg gaggacagaa    300

tcgctgaaaa cctcagcagc cattctcttc gaaattatgc actgaacatc tctgagaagc    360

ggagactaag ggacattcaa gagacacaaa tgaagtatct ctccgaatgg gaccagtgga    420

agcggtatag cagcaagtct tggaagaggt tcctagagaa ggctcgagag atgacgaccc    480

acctggagct gtggcgggag gacatccgca gcatagaagg gaaatttggc actgggattc    540

agtcctattt ctccttcttg agattcctgg tgttgctgaa tttggtgata tttctgatca    600

tctttatgct ggttttgctc ccagtcttac tcacgaaata caagatcacc aacagcagct    660

tcgtgctcat tcctttcaaa gacatggata aacaatgtac agtctatcca gtaagcagtt    720

ctggactcat ttacttttac agttatatca tagacttgct ttctggcact ggtttcctgg    780

aggaaactag cctcttttac ggacattaca ccattgatga ggtgaaattt cagaacttca    840

cctatgatct gcccctggcg tatttgttaa gcacaatcgc ctccctggcc ctgagccttc    900

tttggatagt gaaaaggtcg gtggaaggat tcaaaatcaa cctgattcgg agtgaggagc    960

actttcagag ttactgcaac aagatatttg ccggctggga cttctgcatc actaaccgca   1020

gcatggcgga tctgaagcac agcagcttgc ggtacgagct ccgagcagat ctggaggaag   1080

aaagaatgcg gcagaaaata gcagaaagga cctcagaaga aacaatacgc atttactctt   1140

tgagactgtt tttgaactgt attgttctgg ctgttttagg ggcatgcttt tatgcaatat   1200

acgtagcaac tgtcttctcg caagagcaca tgaaaaagga aatcgacaag atggtttttg   1260

gagagaacct cttcatattg tatctaccgt ctattgtgat cacgctggcc aattttatca   1320

ccccaatgat ctttgccaag atcatccgct atgaggatta ttctccaggc tttgagatcc   1380

gtctgacaat ccttaggtgt gtctttatgc ggctggccac catatgtgtc ctggtgttca   1440

cgctgggctc caagatcaca tcctgtgatg atgacacatg tgacctttgc ggctacaacc   1500

agaaactcta cccgtgctgg gagacccaag ttgggcagga aatgtacaag ctgatgatct   1560

tcgacttcat catcatcttg gctgtgacac tcttcgtgga ttttcctaga aagctcctgg   1620

tgacctactg ttcctcttgc aagctgattc agtgctgggg gcagcaggag tttgccattc   1680

ctgataacgt cctggggata gtttacgggc aaaccatctg ctggatcgga gcctttttct   1740

caccccttct ccctgcaatt gcaaccctga aattcattat catcttctat gtgaaagagt   1800

ggagtctgct ttacacctgc agaccctccc ccaggccgtt cagagcatcc aattctaatt   1860

tcttcttcct gttggtgttg ttgatcgggc tgtgtttggc aataatacct ctgacaatca   1920

gcatatcacg catcccttcc tcgaaagcct gtgggccgtt caccaacttc aacaccacct   1980

gggaggtcat ccccaagaca gtgagcacct tccccagctc gctgcagtcc ttcatccatg   2040

gtgtcacatc cgaagccttt gcagttcctt tcttcatgat tatttgcctc atcatgtttt   2100

acttcattgc cttagctgga gcacacaaac gggtggtcat ccagctccga gagcagctat   2160

ccctggaaag tcgtgacaag tgctacctaa tccagaaact aacagaagcc caaagggaca   2220

tgaggaacta actagactga gcgtgaagat ggtgctgcct gttgcttcta agctgaccta   2280

gtgattctgc tgagcctaca gagtctacct gggttttgag tggacattta aaaatatatt   2340

tttcttgagt ttaggctttt ccatatgtgc agctgtgttt acctaaccca gcccttaatt   2400

agggcttcag tgacttagaa aagcagggga aacccaaggc tttgcctgca gaccggccac   2460

actgtgacaa ctctaccaaa aaccaacaag ccattcaagc ttttacaaga atgaaagagc   2520

ggagacggta gtttagtatt tgagccacga gtttatgtgc acaagtgttt tgggttgtgg   2580

actgaagctc agcctgttaa tcagaccagc ccatgagtgt ataacaaaca gaattggagg   2640

ctggtttctt aaacacacac gtccacattt tttagggttg ttttcctgtg cttacaattt   2700

ttaatgcatg tgcctttatt tcacaaaaca tgtggctggg cgcagcggct cacgcctgtt   2760

atcccaacac tttgggaggc cgaggcaggc ggagcaccta agttggggag ttcaagacct   2820

gcctgaccaa cgtggagaaa ctccgtctcc actaaaatac aaaattagct gggtgtggtg   2880

gcacatgcct gtaatatcag ctactcagga ggctgaggca ggagaattgc ttgaacccag   2940

gaggtggagt ttgcagtgag ctgagatcac accattgcac tccagcctgg gcaaaaagag   3000

caaaactctc cctaaaaaaa aaatgtagaa tatctcttaa gatttccgtt atggtaaaaa   3060

ccatatgcaa taaatacctc attgtaagct tacccaaaat tgatagatgt caacctttta   3120

acagaagaac agaagtttaa gttattgttt aatgtaatca gttttcattt taatatcttt   3180

gaaatctttt tcaaaggact gtagttttgt aatggacttt tcaagccttc cttccattgt   3240

ttttcttccg ttcactggct ccacacgttt cctggggagt agcctggaat ttaaagttgg   3300

gtgcaggttt tagaaagctg ttgctgttaa caataattct cccggccatc tccactccac   3360

tactcaaaaa tgcctgaatc cttgctcaga ggagcaaagg tatcttctcg tccctttctt   3420

acagccattt tcttgctttt ccacaaagat attatttaaa gtggaatatt tttgtaactg   3480

ggataccaat gagcttttcg gtcttttcct gacttggtaa ggtttatggg tttctaaatc   3540

taataactac agtcatacca ccccgaaaaa aaaaaaaaaa a                       3581


<210>  3385
<211>  723
<212>  PRT
<213>  Homosapiens

<400>  3385

Met Ser Glu Ser Ser Gly Ser Ala Leu Gln Pro Gly Arg Pro Ser Arg 
1               5                   10                  15      


Gln Gln Ala Val His Pro Glu Asn Leu Ser Leu Asp Ser Ser Cys Phe 
            20                  25                  30          


Ser Ser Pro Pro Val Asn Phe Leu Gln Glu Leu Pro Ser Tyr Arg Ser 
        35                  40                  45              


Ile Ala Arg Arg Arg Thr Thr Val His Ser Arg Asp Lys Gln Ser Gly 
    50                  55                  60                  


Thr Leu Leu Lys Pro Thr Asp Ser Tyr Ser Ser Gln Leu Glu Asp Arg 
65                  70                  75                  80  


Ile Ala Glu Asn Leu Ser Ser His Ser Leu Arg Asn Tyr Ala Leu Asn 
                85                  90                  95      


Ile Ser Glu Lys Arg Arg Leu Arg Asp Ile Gln Glu Thr Gln Met Lys 
            100                 105                 110         


Tyr Leu Ser Glu Trp Asp Gln Trp Lys Arg Tyr Ser Ser Lys Ser Trp 
        115                 120                 125             


Lys Arg Phe Leu Glu Lys Ala Arg Glu Met Thr Thr His Leu Glu Leu 
    130                 135                 140                 


Trp Arg Glu Asp Ile Arg Ser Ile Glu Gly Lys Phe Gly Thr Gly Ile 
145                 150                 155                 160 


Gln Ser Tyr Phe Ser Phe Leu Arg Phe Leu Val Leu Leu Asn Leu Val 
                165                 170                 175     


Ile Phe Leu Ile Ile Phe Met Leu Val Leu Leu Pro Val Leu Leu Thr 
            180                 185                 190         


Lys Tyr Lys Ile Thr Asn Ser Ser Phe Val Leu Ile Pro Phe Lys Asp 
        195                 200                 205             


Met Asp Lys Gln Cys Thr Val Tyr Pro Val Ser Ser Ser Gly Leu Ile 
    210                 215                 220                 


Tyr Phe Tyr Ser Tyr Ile Ile Asp Leu Leu Ser Gly Thr Gly Phe Leu 
225                 230                 235                 240 


Glu Glu Thr Ser Leu Phe Tyr Gly His Tyr Thr Ile Asp Glu Val Lys 
                245                 250                 255     


Phe Gln Asn Phe Thr Tyr Asp Leu Pro Leu Ala Tyr Leu Leu Ser Thr 
            260                 265                 270         


Ile Ala Ser Leu Ala Leu Ser Leu Leu Trp Ile Val Lys Arg Ser Val 
        275                 280                 285             


Glu Gly Phe Lys Ile Asn Leu Ile Arg Ser Glu Glu His Phe Gln Ser 
    290                 295                 300                 


Tyr Cys Asn Lys Ile Phe Ala Gly Trp Asp Phe Cys Ile Thr Asn Arg 
305                 310                 315                 320 


Ser Met Ala Asp Leu Lys His Ser Ser Leu Arg Tyr Glu Leu Arg Ala 
                325                 330                 335     


Asp Leu Glu Glu Glu Arg Met Arg Gln Lys Ile Ala Glu Arg Thr Ser 
            340                 345                 350         


Glu Glu Thr Ile Arg Ile Tyr Ser Leu Arg Leu Phe Leu Asn Cys Ile 
        355                 360                 365             


Val Leu Ala Val Leu Gly Ala Cys Phe Tyr Ala Ile Tyr Val Ala Thr 
    370                 375                 380                 


Val Phe Ser Gln Glu His Met Lys Lys Glu Ile Asp Lys Met Val Phe 
385                 390                 395                 400 


Gly Glu Asn Leu Phe Ile Leu Tyr Leu Pro Ser Ile Val Ile Thr Leu 
                405                 410                 415     


Ala Asn Phe Ile Thr Pro Met Ile Phe Ala Lys Ile Ile Arg Tyr Glu 
            420                 425                 430         


Asp Tyr Ser Pro Gly Phe Glu Ile Arg Leu Thr Ile Leu Arg Cys Val 
        435                 440                 445             


Phe Met Arg Leu Ala Thr Ile Cys Val Leu Val Phe Thr Leu Gly Ser 
    450                 455                 460                 


Lys Ile Thr Ser Cys Asp Asp Asp Thr Cys Asp Leu Cys Gly Tyr Asn 
465                 470                 475                 480 


Gln Lys Leu Tyr Pro Cys Trp Glu Thr Gln Val Gly Gln Glu Met Tyr 
                485                 490                 495     


Lys Leu Met Ile Phe Asp Phe Ile Ile Ile Leu Ala Val Thr Leu Phe 
            500                 505                 510         


Val Asp Phe Pro Arg Lys Leu Leu Val Thr Tyr Cys Ser Ser Cys Lys 
        515                 520                 525             


Leu Ile Gln Cys Trp Gly Gln Gln Glu Phe Ala Ile Pro Asp Asn Val 
    530                 535                 540                 


Leu Gly Ile Val Tyr Gly Gln Thr Ile Cys Trp Ile Gly Ala Phe Phe 
545                 550                 555                 560 


Ser Pro Leu Leu Pro Ala Ile Ala Thr Leu Lys Phe Ile Ile Ile Phe 
                565                 570                 575     


Tyr Val Lys Glu Trp Ser Leu Leu Tyr Thr Cys Arg Pro Ser Pro Arg 
            580                 585                 590         


Pro Phe Arg Ala Ser Asn Ser Asn Phe Phe Phe Leu Leu Val Leu Leu 
        595                 600                 605             


Ile Gly Leu Cys Leu Ala Ile Ile Pro Leu Thr Ile Ser Ile Ser Arg 
    610                 615                 620                 


Ile Pro Ser Ser Lys Ala Cys Gly Pro Phe Thr Asn Phe Asn Thr Thr 
625                 630                 635                 640 


Trp Glu Val Ile Pro Lys Thr Val Ser Thr Phe Pro Ser Ser Leu Gln 
                645                 650                 655     


Ser Phe Ile His Gly Val Thr Ser Glu Ala Phe Ala Val Pro Phe Phe 
            660                 665                 670         


Met Ile Ile Cys Leu Ile Met Phe Tyr Phe Ile Ala Leu Ala Gly Ala 
        675                 680                 685             


His Lys Arg Val Val Ile Gln Leu Arg Glu Gln Leu Ser Leu Glu Ser 
    690                 695                 700                 


Arg Asp Lys Cys Tyr Leu Ile Gln Lys Leu Thr Glu Ala Gln Arg Asp 
705                 710                 715                 720 


Met Arg Asn 
            


<210>  3386
<211>  2591
<212>  DNA
<213>  Homosapiens

<400>  3386
gccaagggca ctattggcca gttccgttca acgaagtggt tgcttttttt agttccggca     60

atgagttgcg ccggggcggc ggcggctccc cgcctttggc ggctgcgccc gggggcccgg    120

cggtccctct cagcttatgg aagaagaacc agtgtcagat ttcgcagttc aggaatgact    180

ttagacaata tcagtcgggc agctgtggat cgaataatcc gggtggatca tgcaggcgaa    240

tatggagcaa accgcatcta tgccgggcag atggctgtcc tgggtcggac cagcgtcggg    300

ccagtcattc agaaaatgtg ggatcaagaa aaggaccatt tgaaaaagtt caatgagttg    360

atggttacgt tcagggtccg gccaacagtt ctgatgccct tgtggaacgt gctggggttt    420

gcactggggg cggggaccgc cttgctcggg aaggaaggtg ccatggcctg caccgtggcg    480

gtggaagaga gcatagcaca tcactacaac aaccagatca ggacgctgat ggaggaggac    540

cctgaaaaat acgaggaact tcttcagctg ataaagaaat ttcgggatga agagcttgag    600

caccatgaca taggcctcga ccatgatgca gaattggctc cagcctatgc cgtcctgaag    660

agcattatcc aggccggatg cagagtggcg atatatttat cagaaagatt ataaagtgtg    720

tccagttttg cctgtctata aaagatgata gtaatttacc aagtgacatt tgcagagaaa    780

caggtgtaca gttatcgttg tacttttgta caatgtgaat tttgttaata aattataagg    840

tttgtttttt tttttttaaa ctctgcagtg ttgatttttc tctgggttgt tttttctgcc    900

atgagaccaa caggtcacca gccttgttca agttacagca aacgaagctg ggccttgttt    960

ggtctcatac ttaattttct tttatataca tgtttttctt ttacatgcat atatatatat   1020

tttattttat tttatgtttt ttggagacag ggcctcgctc ttttgtccag gccgggtcac   1080

aactcactgc agcctggacc tcctagcctc aagcaatcca cccacctcag ccttccaagt   1140

agctgggact acaggtgtgc accaccacag ctggctaatt ctattttttt atagaggcga   1200

agtctcacta tgtcgccagg ctggtctcta actcctgggc tcagtgatcc tcccgtttcg   1260

acttcccaaa gtgctgggat tacaggtgtg agccacttca ccaggcccat tttctcctaa   1320

aacttcaagg acaaatcatt aataatgtaa caggaatctt taggagaaaa aacaatttgg   1380

tttactgata acaaaagata attggaaaca tgagagtatt tgagattggc caagcagaac   1440

tatgaagtcc atcaagtaag tcaaagatca tcgtttctgt tttgaattgt gggtgataat   1500

gggtgggaga gtgctacagt ctgtatgtct gtgtctccct agaattcata cgatgaaatc   1560

ttcactctca agttgataga aggtggggcc cttgggaagt gtgaggtcat gagagtggag   1620

ccctcatgaa tgggatcagt gccttatgaa aggccctaga gagatacctc atcctctcca   1680

cagtgtgaga cttcaagggg aagtatgaga cttctctgag gaagcagacc cttcacaagc   1740

aaaatcagcc agcactttga tcacggactt cccagcctct aggactgtga gcaataaatg   1800

tttgatgttt ataagccacc cagactgtgg tattttgtta tagcagcctg aacagactaa   1860

gacgggggtg ttgcttccat caaaggatgt actaagttgt ggattatttg tgaaattgaa   1920

ttacaacctt ttccttaagg tcttttacca cctccccccc aaaaaaatcc cccaaaactg   1980

attcagattt tcatacttta atgaaatatt ttataatttg caaattttta agtaatttat   2040

gaaaaaccta gatcagtgga tctcctctct ggctgcccat tagaatgtcc tgtggagatt   2100

aaactttttt ttttcagttt atggaccaag agttttgatt tatttagggt ggagttcagg   2160

atcagaatgg tttcagaagc tcccaggtga ttccggagtg agttggagct gcaagcccct   2220

gagctagatt ataagatgct tctgggaaag aaccacattt taggaatttg cttcccaccc   2280

agtgccctgc atttaatcag cacctgatga cttggcagga cttgccccac cagggtctgg   2340

ctttgaaggg tagtggacac caggatcctt tggattaatc ctctgccacc tctctctttt   2400

cctcaaccga gagtgaattt atgtaattga gtgaaagtct acgaatcata attgtaataa   2460

attaaggctg ggcatttgtt tgaaattaga taggataaag ccaaaggttt gaacaagttg   2520

tggatggttt gtaaaaatta atcttacaaa ataaatgctg tgtgtgaaca cgttgattaa   2580

attcaaaaaa a                                                        2591


<210>  3387
<211>  217
<212>  PRT
<213>  Homosapiens

<400>  3387

Met Ser Cys Ala Gly Ala Ala Ala Ala Pro Arg Leu Trp Arg Leu Arg 
1               5                   10                  15      


Pro Gly Ala Arg Arg Ser Leu Ser Ala Tyr Gly Arg Arg Thr Ser Val 
            20                  25                  30          


Arg Phe Arg Ser Ser Gly Met Thr Leu Asp Asn Ile Ser Arg Ala Ala 
        35                  40                  45              


Val Asp Arg Ile Ile Arg Val Asp His Ala Gly Glu Tyr Gly Ala Asn 
    50                  55                  60                  


Arg Ile Tyr Ala Gly Gln Met Ala Val Leu Gly Arg Thr Ser Val Gly 
65                  70                  75                  80  


Pro Val Ile Gln Lys Met Trp Asp Gln Glu Lys Asp His Leu Lys Lys 
                85                  90                  95      


Phe Asn Glu Leu Met Val Thr Phe Arg Val Arg Pro Thr Val Leu Met 
            100                 105                 110         


Pro Leu Trp Asn Val Leu Gly Phe Ala Leu Gly Ala Gly Thr Ala Leu 
        115                 120                 125             


Leu Gly Lys Glu Gly Ala Met Ala Cys Thr Val Ala Val Glu Glu Ser 
    130                 135                 140                 


Ile Ala His His Tyr Asn Asn Gln Ile Arg Thr Leu Met Glu Glu Asp 
145                 150                 155                 160 


Pro Glu Lys Tyr Glu Glu Leu Leu Gln Leu Ile Lys Lys Phe Arg Asp 
                165                 170                 175     


Glu Glu Leu Glu His His Asp Ile Gly Leu Asp His Asp Ala Glu Leu 
            180                 185                 190         


Ala Pro Ala Tyr Ala Val Leu Lys Ser Ile Ile Gln Ala Gly Cys Arg 
        195                 200                 205             


Val Ala Ile Tyr Leu Ser Glu Arg Leu 
    210                 215         


<210>  3388
<211>  1738
<212>  DNA
<213>  Homosapiens

<400>  3388
ctgtgcgcat gctgggcttg ggtcgccgcc ggggcttgcc ccctgggctg ctcggccacc     60

gccgccccgg gcgcccggca tgtcggtgca ctacaccctc aatctacgcg tcttctggcc    120

cctggtgacc ggcctgtgca ccgccctggt gtgcctctac catgtcctgc ggggaagcgg    180

gggcgcccgg gccgagcccg ccgacggcgt ggatggcggc ttcccgttgc ttaaggtggc    240

cgtcctgctc ctcctcagct atgtcctcct gcgctgtcgc cacgctgtcc ggcagcgctt    300

cctgcccggg tctccccgtc tggagggtca cgccgccttc tcctcgagac acttccgaga    360

gccgggcctc agcatcctgc tggagagtta ctacgagcat gaggtgcgcc tgtctccgca    420

cgtgttgggc cacagcaagg cgcacgtgag ccggatcgtg ggcgagctgg tgcgggctgg    480

ccgcgcccgg gggtcccccg gtctcattcc tgggggagcg ctggccttgg ccttccgcgg    540

agacttcatc caggtgggca gcgcctacga gcaacataaa atccgccggc ccgacagctt    600

cgacgtgctg gtgccactgc gcctcccgcc gcttgtggcg ctggagccac ggagcctggg    660

cgaggagcca gcgctggccc cggccttccg cggctgcttc ttgtgcgccc tcaaggcacc    720

accctcacca tcgggggcct cggggggcca ctggcttcgg gactgcaaac cctttgctga    780

tgccttctgc gtggatgtgc gcgggcggcg tcacctctct gctactctgg tgctgcgctg    840

gttccagtcg catctgcagc gctccttggc cactgtgcgt tacagcctgg aggggcgctg    900

tcgggtcacc ttgaccccag gtggcctgga acagcccccc accttacaca tcttgccctg    960

ccgcactgac tacggctgct gccgcctttc tatggctgtg cgtctcatcc ccgctgtcca   1020

tctgggagat ggggtcttcc ttgtggcgcc accaccgcca cccttgccca gcgcgcccct   1080

gttggagctc cctgagggcc tgcgtgcgga ggcactgtgg ggtgtgaaca cagcacgcca   1140

ggagcagaag ctgctgagtt ggctgcagga acgggcagct ccaggtgcct gctacctcaa   1200

gtgcctgcag ttgcttaagg ctctgcgcga tctgggggcc cgtgggctgg actcagcggc   1260

cgccacccag tggggacgca tcctatcctc atatgtgctc aagacagtgc tgctggcagt   1320

gctgctgcgc aagggggccc ctgggcaagg ctgggacgag gagcacctgg gaaggtgttt   1380

ggaggagttg gtgcagttcc ttagggactg cctgctgcga cgccatacgc tcttccactg   1440

cgtcctgggc cctggtgggg cggctgccga ggtgggtccc ctgcccaagg cactgaggga   1500

agccgcccca gttgacctcc tggccgcttt cgacgggcac gcccgggaac ttgcagcagc   1560

gcggttgctg tccacgtggc aaaggctgcc ccagcttctc cgggcctacg ggggtccccg   1620

ctaccttgcc aggtgccccc caccccggag tcagcgcacc cagggcttcc ttgaaggtga   1680

accgtaaacc ctgacagcac ccccacctga ccaaatgctc ctaaagcctt tcccactg     1738


<210>  3389
<211>  535
<212>  PRT
<213>  Homosapiens

<400>  3389

Met Ser Val His Tyr Thr Leu Asn Leu Arg Val Phe Trp Pro Leu Val 
1               5                   10                  15      


Thr Gly Leu Cys Thr Ala Leu Val Cys Leu Tyr His Val Leu Arg Gly 
            20                  25                  30          


Ser Gly Gly Ala Arg Ala Glu Pro Ala Asp Gly Val Asp Gly Gly Phe 
        35                  40                  45              


Pro Leu Leu Lys Val Ala Val Leu Leu Leu Leu Ser Tyr Val Leu Leu 
    50                  55                  60                  


Arg Cys Arg His Ala Val Arg Gln Arg Phe Leu Pro Gly Ser Pro Arg 
65                  70                  75                  80  


Leu Glu Gly His Ala Ala Phe Ser Ser Arg His Phe Arg Glu Pro Gly 
                85                  90                  95      


Leu Ser Ile Leu Leu Glu Ser Tyr Tyr Glu His Glu Val Arg Leu Ser 
            100                 105                 110         


Pro His Val Leu Gly His Ser Lys Ala His Val Ser Arg Ile Val Gly 
        115                 120                 125             


Glu Leu Val Arg Ala Gly Arg Ala Arg Gly Ser Pro Gly Leu Ile Pro 
    130                 135                 140                 


Gly Gly Ala Leu Ala Leu Ala Phe Arg Gly Asp Phe Ile Gln Val Gly 
145                 150                 155                 160 


Ser Ala Tyr Glu Gln His Lys Ile Arg Arg Pro Asp Ser Phe Asp Val 
                165                 170                 175     


Leu Val Pro Leu Arg Leu Pro Pro Leu Val Ala Leu Glu Pro Arg Ser 
            180                 185                 190         


Leu Gly Glu Glu Pro Ala Leu Ala Pro Ala Phe Arg Gly Cys Phe Leu 
        195                 200                 205             


Cys Ala Leu Lys Ala Pro Pro Ser Pro Ser Gly Ala Ser Gly Gly His 
    210                 215                 220                 


Trp Leu Arg Asp Cys Lys Pro Phe Ala Asp Ala Phe Cys Val Asp Val 
225                 230                 235                 240 


Arg Gly Arg Arg His Leu Ser Ala Thr Leu Val Leu Arg Trp Phe Gln 
                245                 250                 255     


Ser His Leu Gln Arg Ser Leu Ala Thr Val Arg Tyr Ser Leu Glu Gly 
            260                 265                 270         


Arg Cys Arg Val Thr Leu Thr Pro Gly Gly Leu Glu Gln Pro Pro Thr 
        275                 280                 285             


Leu His Ile Leu Pro Cys Arg Thr Asp Tyr Gly Cys Cys Arg Leu Ser 
    290                 295                 300                 


Met Ala Val Arg Leu Ile Pro Ala Val His Leu Gly Asp Gly Val Phe 
305                 310                 315                 320 


Leu Val Ala Pro Pro Pro Pro Pro Leu Pro Ser Ala Pro Leu Leu Glu 
                325                 330                 335     


Leu Pro Glu Gly Leu Arg Ala Glu Ala Leu Trp Gly Val Asn Thr Ala 
            340                 345                 350         


Arg Gln Glu Gln Lys Leu Leu Ser Trp Leu Gln Glu Arg Ala Ala Pro 
        355                 360                 365             


Gly Ala Cys Tyr Leu Lys Cys Leu Gln Leu Leu Lys Ala Leu Arg Asp 
    370                 375                 380                 


Leu Gly Ala Arg Gly Leu Asp Ser Ala Ala Ala Thr Gln Trp Gly Arg 
385                 390                 395                 400 


Ile Leu Ser Ser Tyr Val Leu Lys Thr Val Leu Leu Ala Val Leu Leu 
                405                 410                 415     


Arg Lys Gly Ala Pro Gly Gln Gly Trp Asp Glu Glu His Leu Gly Arg 
            420                 425                 430         


Cys Leu Glu Glu Leu Val Gln Phe Leu Arg Asp Cys Leu Leu Arg Arg 
        435                 440                 445             


His Thr Leu Phe His Cys Val Leu Gly Pro Gly Gly Ala Ala Ala Glu 
    450                 455                 460                 


Val Gly Pro Leu Pro Lys Ala Leu Arg Glu Ala Ala Pro Val Asp Leu 
465                 470                 475                 480 


Leu Ala Ala Phe Asp Gly His Ala Arg Glu Leu Ala Ala Ala Arg Leu 
                485                 490                 495     


Leu Ser Thr Trp Gln Arg Leu Pro Gln Leu Leu Arg Ala Tyr Gly Gly 
            500                 505                 510         


Pro Arg Tyr Leu Ala Arg Cys Pro Pro Pro Arg Ser Gln Arg Thr Gln 
        515                 520                 525             


Gly Phe Leu Glu Gly Glu Pro 
    530                 535 


<210>  3390
<211>  7121
<212>  DNA
<213>  Homosapiens

<400>  3390
ggcccggccc gcggcggcgg caaaggggcg gaggggttcg ctgccagcaa ttgccaagct     60

gctgcggtcg tggcgggatg gtatagccgg gcctgagggc gggcggcggg gcgcgggcgg    120

gggcgaggcg gccgggaagg gccgacgccg cctgactggc ttgggagcag cggcagcaag    180

ctgagggggc gtcgccgccg ccggcccccg gcgccgccgc gggaggccgc gcccgccatg    240

gcggcccggg cggtgctgga cgagttcact gcgccagctg agaaggcgga gctgctggag    300

cagagccgcg gccgtatcga gggcctgttt ggcgtgagcc tagccgtgct cggcgcgcta    360

ggggctgagg agccgctgcc cgcgcgcatc tggctgcagc tctgcggggc gcaggaggcg    420

gtgcacagcg ccaaggaata tattaaagga atctgtgaac ctgaactaga agaaagagaa    480

tgttacccca aggacatgca ctgcattttt gttggggcag agagcctgtt tctgaaaagc    540

ttgattcagg atacttgtgc tgacctctgc attctggaca ttggccttct tggcatcaga    600

ggaagtgctg aggctgtggt catggctagg agtcacattc aacaatttgt aaagctcttt    660

gaaaataaag agaacctacc cagtagtcag aaagaatcag aggtgaaaag ggaattcaaa    720

caatttgttg aagcccatgc agacaattac acaatggatt tgttgatttt gcccacttcc    780

ttgaaaaaag aacttttgac actcacacaa ggtgaggaga atctctttga aacaggagat    840

gatgaggtta ttgaaatgag agattctcaa caaacagagt ttacacagaa tgctgccaca    900

gggctgaata tttctagaga tgaaactgtt ttgcaggaag aggcaagaaa taaagctggg    960

actcctgttt ctgagcttac aaaacaaatg gacacagtcc tttctagctc accagatgtg   1020

ctttttgatc caataaatgg tctaacccca gatgaagagg cactttccaa tgagagaatt   1080

tgtcagaaaa ggagattttc tgattctgaa gaaaggcata cgaagaagca gttttctttg   1140

gaaaatgttc aggaggggga gattttacac gatgctaaga cattggctgg aaatgtaata   1200

gctgacctat ctgattcttc tgctgattct gaaaatttaa gtccagatat aaaagaaact   1260

actgaggaaa tggaatacaa catcctcgta aactttttta aaaccatggg ctactcccaa   1320

gaaattgttg aaaaggtcat taaggtgtat ggaccatcta ctgaaccatt attgctctta   1380

gaggaaattg aaaaagaaaa taaaagattc caagaagaca gagaattttc agctggtaca   1440

gtgtatccag agaccaacaa aaccaaaaat aaaggtgttt atagcagcac aaatgagctt   1500

acaactgatt ccactccaaa gaaaacacag gctcacacac agcaaaatat ggtagaaaaa   1560

ttttctcagt taccattcaa agtggaagct aaaccatgta cctcaaattg tagaattaat   1620

actttcagaa cagtgccaat agaacagaaa catgaagtct ggggttcaaa ccagaactac   1680

atttgtaaca cagaccctga aactgatggc ctttcacctt ctgttgcctc tccaagtccc   1740

aaagaagtca attttgtttc aaggggagct tcaagtcacc agcccagagt tccacttttt   1800

cctgaaaatg gtttacacca gcagccagaa cccttgcttc caaataatat gaaatctgcc   1860

tgtgaaaaac gtttaggatg ttgtagttct cctcattcta agccaaattg ctcaaccctt   1920

tctccaccaa tgccactgcc ccagctgtta ccttcggtta ctgatgcaag gtcggcagga   1980

ccttctgatc atattgattc ctcagttact ggggttcaaa ggtttcgaga tactctaaaa   2040

ataccctaca agctggaatt aaaaaatgaa ccagggagaa cggatttgaa acacattgtt   2100

atagatggga gcaatgttgc aattacccat ggtctgaaaa agttcttttc ttgtcgtgga   2160

attgcaattg cagttgaata tttttggaag cttggcaaca gaaacatcac tgtatttgtc   2220

cctcagtgga gaacaaggcg tgatcctaat gtcacagaac agcacttctt aacccagctc   2280

caggagctcg gaatattatc tttaactcct gcccggatgg tctttggaga aagaattgct   2340

tctcatgatg acaggtttct actacactta gcggacaaaa ctggtggcat aattgtgaca   2400

aatgataatt tcagagaatt tgtgaatgag tcagtctctt ggagagaaat tattacaaaa   2460

aggctgctgc agtacacgtt cgtgggggac atatttatgg ttcccgatga tcctctggga   2520

agaagtggac ctcgattaga ggagtttctt cagaaggaag tctgtcttag agatatgcag   2580

cccctactca gtgccctgcc aaatgtgggc atgtttgacc ccagcttcag agtccctggc   2640

acccaggcag ccagcaccag ccaccagcct ccgacccgga ttcagggagc cccttcaagc   2700

cactggctcc ctcagcagcc ccacttccca ctgctgccag ccctccccag tctccagcag   2760

aacctgccca tgccagctca gagatcttct gcagaaacca acgagctgag ggaagccctt   2820

ctgaagatct tccctgactc agagcaaaga ctgaaaatag accagatctt ggtggcccac   2880

ccatacatga aagatctaaa tgcgctttct gccatggtgt tggattgaag attgtgctga   2940

gcgctgagct tgcgctcagg gctggctgat caaactcaag ctcacacctg tacctgatgg   3000

gaatgaacat aatgtgaaga aacttatttc ccagtgtaaa cgcagttgta cagaaaaaaa   3060

atgttttggg tataaatctg ggttttcaaa accagctttt ttctatatat aaattatgct   3120

gctattacag atttaacatt ttctgttaaa ggaaagtcta cattttctgc ctgttcagaa   3180

ctgtttaata gcagttactc ttgagtgtat ttaccttttt atgtttttta aactattttc   3240

cttaaagccg aaaatattga caaatggata tggttagcct ttataaataa ataaaaaaaa   3300

aagtgttgct ttcttaagga aagcaagacg tcttaaagta tattttcttg agatgagtat   3360

gtcccatcac taccatgaag tgtgctcacc cttccagcct cctctgccct cacccccgga   3420

gttaaagtgg gtaagagttg gtttgttctg cagtctttgg ttggagtgtt gtgaaagtgg   3480

acccgcggtg ccactagatg gcacttggtg cctagccatg gtgaatgacc agggcgaagt   3540

tagtctcaca gaataccagg gctagaagac atcgtggagc ccatggagtc ccaccctcct   3600

tcccccttcc accctgcgca aaaggggacg gcccagtgtg cacgccgtcc ggccatgccc   3660

acagccacag ccacagctga ggagtggccg ggcaggcagc aggctcccca gccagggctt   3720

gacacgccca cagtcagggg cctccacatg cctggcctgg ctctggaagt cacgtcttag   3780

cttctgaaca ccgtagcggg ttatgaggaa gtttaatgaa gagcccggtc actgtggcca   3840

tcttgtgtcc ccaactgcag gagacgccct gatgtggagt ttgtacagct ttgccaaaaa   3900

atggttttct attctcaaaa gtgacccaag ccaataaata gcattagtag cttctgtggg   3960

gggatcccag agcccctgta tttattttcc ctgtgtttgt ctctagtgtc ctcctaaaca   4020

gcctttcctg tgagtctttc tcagaattga tatcttaata ttgtctgttc taggtgttgc   4080

ccaaattcag tgtcagtgaa gttcttttcc tgggcaatct taacatcttt actcttattg   4140

tctggacctt caaagggctt tgtattttac acctgcgccc ccaggctgct cacagtcggc   4200

ttgctgcctg tcctgcctgt ccggatcttg tctcctagtc ctgaggagcg gaggctgaga   4260

actcagtgct ggtttgtaaa tggtgagggg acttgggggc atcccagagt gctccctcca   4320

ggcctgcttc ttggttttgt ttgatcactg cgttcttcaa gggatgaatc cagagccctc   4380

catgaggcca agcttgtcct tcaatcatgt ttcctctcag atgcgtccgt gatgcctcct   4440

aatgtggaac tggttgtcca ttgtttgggc ctatggccaa gtcacccagc tgtggaagca   4500

gaggtagaag acgaggccag ccaggagggc gacttcagtc acagctccca tgcctcagct   4560

ttgtacctgt tttcaaaagc acaactgagg tgtgcgggct ggagctgtct tgcagtgatt   4620

ctggccttct ggctcatggt tcagtccagc agcctggctg acccactatt tctcctctgc   4680

ttcagaggaa acccaggaaa tgcccttact gccaggctga gtctccaccc atgctggttg   4740

gtgctggcta ggctgagggg gccaccactt ttcctggcta gaagctactt gacctttgat   4800

gtttgagttc tgtaagtctt cgtgttctga cttactgctt cagagggatt ggcctgtccc   4860

ctttcccttt ctcggctatg ggaaggaagg attgctcatt ggttgccttc atcagttaca   4920

gcatgagacg gaattcatca ttccttccga aacccctgat atttaatatt taatatttaa   4980

aaacccaaat tatcaaacca ttaagaactc attactggtt ctcagcctcc tccagtacta   5040

gcctcagtgt ggctgctgca taagtatctg tagcctgtct acctcctgca gtggggccgc   5100

tcgcctcttc cctgtctact gctcaggctc tcccacttcg tggcatccat gtaaagtagg   5160

tggcagggca gagatgtcac tctcattcaa cagggaggat gtctgttgct cagagaggtt   5220

gtcctgaggg gctgggtgat tcctgggcct acattcttcc cgaggctcca ggccgctgtc   5280

tctggaagta aaagagcctt gtctgacctt aatgcaagca gtctgtttga acccctgtag   5340

gctgcattca ggagacagaa ggtgtctggg ccatcctggg cggccggtca gcgttgctag   5400

gcaggctcgg ctgtctggcc gggacttggg cctgggtggc ttttgagacc agtgaagaag   5460

ggagagccgg cctcatgccg atgcggcttg tggcacggct gggatgtgag ggaggactca   5520

gatctacaca cagaaacccc tcttctcccc gccctccccc agctcctacc tgcctcccac   5580

gcctcaggtg tggctgcctg tgggaccatc ccccaacccc tttcctcgca cctccttgtc   5640

ctcacccagt tcctgcagtg tctctgaccc acgcctcccg cctcctggcc gacttgccca   5700

ggaggtgtct ctggctcacc tccgtctgtt catcaccttc ctccccagtg tttccactta   5760

tcttggatgt tttagattga aacagcctga ttcccggaag aatcctcttc attcattgct   5820

agtgcttccc ctcacctccc actctccact tcccagtttg caaatgtggc tttcgcccac   5880

caagtgaaag cggactgaga gcagcccttg gggacggccc ggtgcctggc tgcaaggccg   5940

cgctggggct ctgtcttggt gcacatggct tgaccggact ttccctgctt cccaccactt   6000

ccctcactcc cagacctccc tcattctttt tgtctcttct ttttgcctaa agccagtcct   6060

taacacccta ttcttcctct gcaggtggct tgcagacttt tccccacctt tggggctcgt   6120

ggtggtggag agggcagctg gtgttaagaa tgtaggttac cgggcatgac ccggcagatg   6180

cttgcccagt agttctggag gaaggcccgg gaatctgcaa atgagcgcat tccccaggca   6240

gttcccatgc aggtgatcca cggaccacat gttgagaaac tgcagtcacc cttagggcca   6300

caccgtccct ctcctcgctg tcccctctct gtagtgactg gccctgacct tcaggagtgc   6360

actttccact ctaccaggaa gccctatgac atcctcaggc tccccagacc tgcagcttgc   6420

atggggcccc tcccttcttc cacacccacc ctccgtatgg tcccctgctc tgccctcgtg   6480

ctttgctggc ccctgcccgc tactcccact ctcagacacc caggggtggt gggccctaac   6540

tggctggccc ctcccagcgc tgccctctgc cgtccagatg ctgcagtgtg gccagattta   6600

ccttccagta acatacttct agtcacccct cctcctgcga agtgatctgc agtggctgtt   6660

tgaccagacc acaaagttca catctcctga gcttagtgtc cgtggctgtc cacctcccag   6720

ccatacttga ctgtccccaa actctccctg cagccacatg tttcccatga cctgtgggct   6780

ctgcagatgg acctctctcc gctagagatg cccttctccc aaatggcttc cctcctggaa   6840

ggcccagcct gagtcctcgt ctcctttcca gtgcttctgc cagaagcatc cccatgatgt   6900

tgtgaccgca cagcactttg tgtctcgctt tgagcacttg ccactctggc tggtgctgct   6960

gccactgatt gtgtactgtc ttgctgccct ttctagactg tgagctcctc gtgggcaggg   7020

accgcctgtg ttctctgtat ttcccacggc gcctagcaca gtgccttgca cttgataggt   7080

gcttaataaa tgtctgctca actgaaaaaa aaaaaaaaaa a                       7121


<210>  3391
<211>  896
<212>  PRT
<213>  Homosapiens

<400>  3391

Met Ala Ala Arg Ala Val Leu Asp Glu Phe Thr Ala Pro Ala Glu Lys 
1               5                   10                  15      


Ala Glu Leu Leu Glu Gln Ser Arg Gly Arg Ile Glu Gly Leu Phe Gly 
            20                  25                  30          


Val Ser Leu Ala Val Leu Gly Ala Leu Gly Ala Glu Glu Pro Leu Pro 
        35                  40                  45              


Ala Arg Ile Trp Leu Gln Leu Cys Gly Ala Gln Glu Ala Val His Ser 
    50                  55                  60                  


Ala Lys Glu Tyr Ile Lys Gly Ile Cys Glu Pro Glu Leu Glu Glu Arg 
65                  70                  75                  80  


Glu Cys Tyr Pro Lys Asp Met His Cys Ile Phe Val Gly Ala Glu Ser 
                85                  90                  95      


Leu Phe Leu Lys Ser Leu Ile Gln Asp Thr Cys Ala Asp Leu Cys Ile 
            100                 105                 110         


Leu Asp Ile Gly Leu Leu Gly Ile Arg Gly Ser Ala Glu Ala Val Val 
        115                 120                 125             


Met Ala Arg Ser His Ile Gln Gln Phe Val Lys Leu Phe Glu Asn Lys 
    130                 135                 140                 


Glu Asn Leu Pro Ser Ser Gln Lys Glu Ser Glu Val Lys Arg Glu Phe 
145                 150                 155                 160 


Lys Gln Phe Val Glu Ala His Ala Asp Asn Tyr Thr Met Asp Leu Leu 
                165                 170                 175     


Ile Leu Pro Thr Ser Leu Lys Lys Glu Leu Leu Thr Leu Thr Gln Gly 
            180                 185                 190         


Glu Glu Asn Leu Phe Glu Thr Gly Asp Asp Glu Val Ile Glu Met Arg 
        195                 200                 205             


Asp Ser Gln Gln Thr Glu Phe Thr Gln Asn Ala Ala Thr Gly Leu Asn 
    210                 215                 220                 


Ile Ser Arg Asp Glu Thr Val Leu Gln Glu Glu Ala Arg Asn Lys Ala 
225                 230                 235                 240 


Gly Thr Pro Val Ser Glu Leu Thr Lys Gln Met Asp Thr Val Leu Ser 
                245                 250                 255     


Ser Ser Pro Asp Val Leu Phe Asp Pro Ile Asn Gly Leu Thr Pro Asp 
            260                 265                 270         


Glu Glu Ala Leu Ser Asn Glu Arg Ile Cys Gln Lys Arg Arg Phe Ser 
        275                 280                 285             


Asp Ser Glu Glu Arg His Thr Lys Lys Gln Phe Ser Leu Glu Asn Val 
    290                 295                 300                 


Gln Glu Gly Glu Ile Leu His Asp Ala Lys Thr Leu Ala Gly Asn Val 
305                 310                 315                 320 


Ile Ala Asp Leu Ser Asp Ser Ser Ala Asp Ser Glu Asn Leu Ser Pro 
                325                 330                 335     


Asp Ile Lys Glu Thr Thr Glu Glu Met Glu Tyr Asn Ile Leu Val Asn 
            340                 345                 350         


Phe Phe Lys Thr Met Gly Tyr Ser Gln Glu Ile Val Glu Lys Val Ile 
        355                 360                 365             


Lys Val Tyr Gly Pro Ser Thr Glu Pro Leu Leu Leu Leu Glu Glu Ile 
    370                 375                 380                 


Glu Lys Glu Asn Lys Arg Phe Gln Glu Asp Arg Glu Phe Ser Ala Gly 
385                 390                 395                 400 


Thr Val Tyr Pro Glu Thr Asn Lys Thr Lys Asn Lys Gly Val Tyr Ser 
                405                 410                 415     


Ser Thr Asn Glu Leu Thr Thr Asp Ser Thr Pro Lys Lys Thr Gln Ala 
            420                 425                 430         


His Thr Gln Gln Asn Met Val Glu Lys Phe Ser Gln Leu Pro Phe Lys 
        435                 440                 445             


Val Glu Ala Lys Pro Cys Thr Ser Asn Cys Arg Ile Asn Thr Phe Arg 
    450                 455                 460                 


Thr Val Pro Ile Glu Gln Lys His Glu Val Trp Gly Ser Asn Gln Asn 
465                 470                 475                 480 


Tyr Ile Cys Asn Thr Asp Pro Glu Thr Asp Gly Leu Ser Pro Ser Val 
                485                 490                 495     


Ala Ser Pro Ser Pro Lys Glu Val Asn Phe Val Ser Arg Gly Ala Ser 
            500                 505                 510         


Ser His Gln Pro Arg Val Pro Leu Phe Pro Glu Asn Gly Leu His Gln 
        515                 520                 525             


Gln Pro Glu Pro Leu Leu Pro Asn Asn Met Lys Ser Ala Cys Glu Lys 
    530                 535                 540                 


Arg Leu Gly Cys Cys Ser Ser Pro His Ser Lys Pro Asn Cys Ser Thr 
545                 550                 555                 560 


Leu Ser Pro Pro Met Pro Leu Pro Gln Leu Leu Pro Ser Val Thr Asp 
                565                 570                 575     


Ala Arg Ser Ala Gly Pro Ser Asp His Ile Asp Ser Ser Val Thr Gly 
            580                 585                 590         


Val Gln Arg Phe Arg Asp Thr Leu Lys Ile Pro Tyr Lys Leu Glu Leu 
        595                 600                 605             


Lys Asn Glu Pro Gly Arg Thr Asp Leu Lys His Ile Val Ile Asp Gly 
    610                 615                 620                 


Ser Asn Val Ala Ile Thr His Gly Leu Lys Lys Phe Phe Ser Cys Arg 
625                 630                 635                 640 


Gly Ile Ala Ile Ala Val Glu Tyr Phe Trp Lys Leu Gly Asn Arg Asn 
                645                 650                 655     


Ile Thr Val Phe Val Pro Gln Trp Arg Thr Arg Arg Asp Pro Asn Val 
            660                 665                 670         


Thr Glu Gln His Phe Leu Thr Gln Leu Gln Glu Leu Gly Ile Leu Ser 
        675                 680                 685             


Leu Thr Pro Ala Arg Met Val Phe Gly Glu Arg Ile Ala Ser His Asp 
    690                 695                 700                 


Asp Arg Phe Leu Leu His Leu Ala Asp Lys Thr Gly Gly Ile Ile Val 
705                 710                 715                 720 


Thr Asn Asp Asn Phe Arg Glu Phe Val Asn Glu Ser Val Ser Trp Arg 
                725                 730                 735     


Glu Ile Ile Thr Lys Arg Leu Leu Gln Tyr Thr Phe Val Gly Asp Ile 
            740                 745                 750         


Phe Met Val Pro Asp Asp Pro Leu Gly Arg Ser Gly Pro Arg Leu Glu 
        755                 760                 765             


Glu Phe Leu Gln Lys Glu Val Cys Leu Arg Asp Met Gln Pro Leu Leu 
    770                 775                 780                 


Ser Ala Leu Pro Asn Val Gly Met Phe Asp Pro Ser Phe Arg Val Pro 
785                 790                 795                 800 


Gly Thr Gln Ala Ala Ser Thr Ser His Gln Pro Pro Thr Arg Ile Gln 
                805                 810                 815     


Gly Ala Pro Ser Ser His Trp Leu Pro Gln Gln Pro His Phe Pro Leu 
            820                 825                 830         


Leu Pro Ala Leu Pro Ser Leu Gln Gln Asn Leu Pro Met Pro Ala Gln 
        835                 840                 845             


Arg Ser Ser Ala Glu Thr Asn Glu Leu Arg Glu Ala Leu Leu Lys Ile 
    850                 855                 860                 


Phe Pro Asp Ser Glu Gln Arg Leu Lys Ile Asp Gln Ile Leu Val Ala 
865                 870                 875                 880 


His Pro Tyr Met Lys Asp Leu Asn Ala Leu Ser Ala Met Val Leu Asp 
                885                 890                 895     


<210>  3392
<211>  2130
<212>  DNA
<213>  Homosapiens

<400>  3392
aggacagggc agcggcggtg acccgagctg ccgcccgaca tgaactcgct ggagcaggcg     60

gaagccccgc gagttgtatc cctgattcct gcggtggttt ccggtaactg ccaagatctc    120

aaggcttttg agaggagact tactgaatat attcattgtt tgcaacctgc tactggacgc    180

tggagaatgc ttcttatagt ggtatctgtc tgtacagcta ctggtgcctg gaactggtta    240

atagaccctg agacacaaaa ggtgtccttc ttcacatcat tatggaatca cccatttttc    300

accattagct gtatcactct aataggcttg ttctttgctg gaatacacaa gagagtagtt    360

gcaccatcaa ttatagctgc tcgatgtcga acggtattag cagaatacaa tatgtcttgt    420

gatgatacag gaaaactaat tttgaaacct aggcctcatg ttcaatgaca atcttcactc    480

attgttatgg gacttaaaat agcctttctt cgaataagtg atacagcaaa aagccataaa    540

ggattccttt tgcggttgga tatgtaaagg tcatagcagc aactgacaag aagtgtgcaa    600

tatttacctg gattatcttg atgatggtga ctcattatca gtgctttggt acttttgatt    660

acctgtgttt cagtattagt gtcactttag tacttcagat cctgcaaata tttttgcaga    720

tgaagtatgt atgtatgtta ctaagttaaa cttagaaaca gaacctcatt cagtttttat    780

aatgtatttt tgcaaactac tgtaaatagc aaatcaatgc caatgttaaa caaagaggaa    840

aacgttgtgt ggactttgtt ctcttgcacc ggtatttcag gaacatctgc ttgccatccc    900

cacagctctt taaaactggc tattatgtgt gcctttcatt cttacatttc taatcatact    960

gcaggaaaaa cattggattc agcttagact gaggaaaact ctccattatg ttgtaagaaa   1020

ttatagatgt tttgagagac actttttgtt aaaccagata ttgaactcca gcaactattg   1080

tggttatatt tttagttcat tgttctcatt taatgctaaa tatcctttat attgctttaa   1140

taattttctt tttttttttt ttttttttag acggagtctc gctctgttgc caggctggag   1200

ggcagtggca cgatcttggc tttctgcaac ctctgcctcc caggttcaag cgattctcct   1260

gcttcagcct tccgagtagc tgggactaca ggcgcatgcc accatgccca gctaattttt   1320

ttgtattttt agtagagacg gggtttcacc acgttggcca ggatggtttc gatctcctga   1380

cctcgtgatc ctcctgcctc atcctcccaa aatgctggga ttacaggcat aagccaccgt   1440

gcctggcctc tttaataatt tttaaaatac cctaaaggct tgtgaatata caagtctact   1500

gataaattat gtattgtctg ggaatttgat agtcattgtt ttagataact ggattttacg   1560

ctgtggtaga caggctgtga cactagtgtt gcacaggtgt aattggtcat cctatgcctt   1620

caccagaata acttgggagt ggtgccagaa actagagtct acaattctca ctgtttagag   1680

agtgttaatg acatactgtg tatgcataat agccgcatgt actataatag cccttaaaat   1740

taaactattg ggattgctgt aaatatttta aagtactgga ggtgcctttt acctgtttat   1800

tagattttga aaaggtttaa attatttcat gagcaatctt ttaaatttca tttaacataa   1860

agctgaaaat tcaataacag gataaaaaag ctttttaaca aggctgccat ttaacttaaa   1920

tgtgttcatc ttagctttca cttgtataaa atttgattct ttgaactgca gcaataaaac   1980

cctcagctcc taagaagtct taagagggta ttctatatat tctgctttgt tttattttct   2040

gtaaattttg taggtaaata tgtgcattaa aaataaatac tttatatata actcgtgaaa   2100

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                    2130


<210>  3393
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  3393

Met Asn Ser Leu Glu Gln Ala Glu Ala Pro Arg Val Val Ser Leu Ile 
1               5                   10                  15      


Pro Ala Val Val Ser Gly Asn Cys Gln Asp Leu Lys Ala Phe Glu Arg 
            20                  25                  30          


Arg Leu Thr Glu Tyr Ile His Cys Leu Gln Pro Ala Thr Gly Arg Trp 
        35                  40                  45              


Arg Met Leu Leu Ile Val Val Ser Val Cys Thr Ala Thr Gly Ala Trp 
    50                  55                  60                  


Asn Trp Leu Ile Asp Pro Glu Thr Gln Lys Val Ser Phe Phe Thr Ser 
65                  70                  75                  80  


Leu Trp Asn His Pro Phe Phe Thr Ile Ser Cys Ile Thr Leu Ile Gly 
                85                  90                  95      


Leu Phe Phe Ala Gly Ile His Lys Arg Val Val Ala Pro Ser Ile Ile 
            100                 105                 110         


Ala Ala Arg Cys Arg Thr Val Leu Ala Glu Tyr Asn Met Ser Cys Asp 
        115                 120                 125             


Asp Thr Gly Lys Leu Ile Leu Lys Pro Arg Pro His Val Gln 
    130                 135                 140         


<210>  3394
<211>  2625
<212>  DNA
<213>  Homosapiens

<400>  3394
agacgacgcg ccgtgcgcct gcgcacggct tgcccatgtg tgctgcagcc gtcagccggc     60

ccagctgagc agcagcaacg gaccttgtta acggcgcggc agcctccacc gcctgctgtt    120

gccctcctct ctcggtggtc tgtccgccca gcgcacgtca ccatgggcaa gagccggacg    180

aagcgcttca agcgacctca gttctcccct acgggcgact gtcaggccga ggcggctgcg    240

gcggcgaatg ggaccggagg cgaggaggac gacgggccgg cggcggagct gctggaaaag    300

ctccagcacc cgagcgccga ggtccgcgag tgcgcctgcg cagggctggc ccggctggtg    360

cagcagcggc cggcactccc gggcctggcg cgacgagacg ccgtgcgccg cctcgggccg    420

ctgctgctag accccagcct ggccgtcagg gagactgcag ccggcgcgct gagaaatctc    480

agtgcttgtg gaggttttga agtttgtgat gacatggtga ctaaggatat catgacccct    540

ctggttgcgc tgctaaaaga gtgtagtgct ggactggatt caaatgagat gtctctgcag    600

gagaaaaaag atcagaacag aaattctatt gagaacatag ccaatgagac tgtgaacgtg    660

ctgtggaata tatgtgaatg cagtagtaga gcagtgtcta tattcaacaa agaagggtgt    720

ttggagattg tgttaaagta tttaagtagg tttcctacca atgttgacct ggctatttca    780

gtagcatatt gtttgcagac agtgactgag gataacccag agctgctgaa gtctttcagt    840

gctacagcat tgaacatgct ggaatcagca ctgctttctc ctgtcagttc catggaatct    900

cttctattga agacattggt agcaggcaca atttggaatc taaaggacat tattccatgc    960

aagagtcaag cagaaatcat aaatgcctta ctaaagatct tatctgaagt tttgggaatg   1020

gatgctggtg aaatggttat tcaaatgaaa gaggctgaaa cgcaaaggtt aaaaactgct   1080

gcagaggctg aggaaatatt agagaacact aatggggatg atttgattga agatgatgaa   1140

atggaaggaa tttctcataa aagaagagtc agaaggaaaa ctttcgtttc agatttactt   1200

ccgcccactg acaaggaact gagagagact atagcattgc tgacagccca acagactgct   1260

ctggaaatta ttgtcaacat gtgctgcaat gaagatccct ctgatgacga atgggaagag   1320

ctttctagca gtgatgaaag tgacgcattt atggagaatt ccttcagtga gtgcggggga   1380

cagctgtttt ctcccctctg cctctcccat gaagttcaca cggctctcac caactacctc   1440

atcccaaaga agatttttga gaaaactgcc tttccaaaca gcattgcagt tgacctatgt   1500

tctaggaacc ctacttggaa acctttgatt agaaaaatga acactattca gtgcagagcc   1560

ctcttctgtc tccagagtct tgtgtccctc ctggatgtgg agcacctggg aggagccgca   1620

gcccttcaga cgcttgcaca gcatctgtca cagctgcttt tttctcaacc agattttgct   1680

aaacatgttg actttctaga agccataagt agtgctttga gggccctttt gcaaacaatg   1740

gcctccaaga acatttccca gtgcatgact cctgatcagc tgatgacatt atgcaaagca   1800

ggcattcata gtagtaatgt cggggttaga gtgaatgtcg ttagcatttt aggaatcact   1860

ggcagcgtcc ttgccaaaga agatggtaca cttgaaactc ttaagaacat tgggtgcttt   1920

ctgcttgaag ttaccaccaa agatccttcc cttgtggtag caggagaagc tttggatgcc   1980

ctctttgatg tttttgcaga tggtaaagaa gccgaaagag cctcgattca aattaaatta   2040

ttatctgctc tgaaagaatt ccagccggtc tttaaaatga agatacgtaa agaagggaga   2100

ggtaactata gcacagatca gctgtgtgtt cttgacaatg tgaaaatgaa tttgcgaaga   2160

tttattgctt atcaagaaac tgttgagaaa agactgactt cttaaacaat ccaaaaaaga   2220

aaccagttct tcccccaaag tattcaatgc ttagaatact aaaaggtttt ctttgaatgt   2280

atatgtttct gaaagtcatt ttttaatgat tacattctgt acattctgta aaaacttcaa   2340

aacctggcca ggcatggtgg ctcacgccta taatcccagc accttgggag accgaggcgg   2400

gtggatcact tgaggtcagg agtttgaggc cagcctggcc aacatggtga aaccgcatgc   2460

ataagcatgg tggcacatgc ctgtgatccc agctactcgg gaggctgagg gaggagagtc   2520

ggttgaacct gggagacaga ggttgcagtg agctgagatc acgctactgc actccagcct   2580

gggtgacaga gggagaccct gtctccaaaa aaaaaaaaaa aaaaa                   2625


<210>  3395
<211>  680
<212>  PRT
<213>  Homosapiens

<400>  3395

Met Gly Lys Ser Arg Thr Lys Arg Phe Lys Arg Pro Gln Phe Ser Pro 
1               5                   10                  15      


Thr Gly Asp Cys Gln Ala Glu Ala Ala Ala Ala Ala Asn Gly Thr Gly 
            20                  25                  30          


Gly Glu Glu Asp Asp Gly Pro Ala Ala Glu Leu Leu Glu Lys Leu Gln 
        35                  40                  45              


His Pro Ser Ala Glu Val Arg Glu Cys Ala Cys Ala Gly Leu Ala Arg 
    50                  55                  60                  


Leu Val Gln Gln Arg Pro Ala Leu Pro Gly Leu Ala Arg Arg Asp Ala 
65                  70                  75                  80  


Val Arg Arg Leu Gly Pro Leu Leu Leu Asp Pro Ser Leu Ala Val Arg 
                85                  90                  95      


Glu Thr Ala Ala Gly Ala Leu Arg Asn Leu Ser Ala Cys Gly Gly Phe 
            100                 105                 110         


Glu Val Cys Asp Asp Met Val Thr Lys Asp Ile Met Thr Pro Leu Val 
        115                 120                 125             


Ala Leu Leu Lys Glu Cys Ser Ala Gly Leu Asp Ser Asn Glu Met Ser 
    130                 135                 140                 


Leu Gln Glu Lys Lys Asp Gln Asn Arg Asn Ser Ile Glu Asn Ile Ala 
145                 150                 155                 160 


Asn Glu Thr Val Asn Val Leu Trp Asn Ile Cys Glu Cys Ser Ser Arg 
                165                 170                 175     


Ala Val Ser Ile Phe Asn Lys Glu Gly Cys Leu Glu Ile Val Leu Lys 
            180                 185                 190         


Tyr Leu Ser Arg Phe Pro Thr Asn Val Asp Leu Ala Ile Ser Val Ala 
        195                 200                 205             


Tyr Cys Leu Gln Thr Val Thr Glu Asp Asn Pro Glu Leu Leu Lys Ser 
    210                 215                 220                 


Phe Ser Ala Thr Ala Leu Asn Met Leu Glu Ser Ala Leu Leu Ser Pro 
225                 230                 235                 240 


Val Ser Ser Met Glu Ser Leu Leu Leu Lys Thr Leu Val Ala Gly Thr 
                245                 250                 255     


Ile Trp Asn Leu Lys Asp Ile Ile Pro Cys Lys Ser Gln Ala Glu Ile 
            260                 265                 270         


Ile Asn Ala Leu Leu Lys Ile Leu Ser Glu Val Leu Gly Met Asp Ala 
        275                 280                 285             


Gly Glu Met Val Ile Gln Met Lys Glu Ala Glu Thr Gln Arg Leu Lys 
    290                 295                 300                 


Thr Ala Ala Glu Ala Glu Glu Ile Leu Glu Asn Thr Asn Gly Asp Asp 
305                 310                 315                 320 


Leu Ile Glu Asp Asp Glu Met Glu Gly Ile Ser His Lys Arg Arg Val 
                325                 330                 335     


Arg Arg Lys Thr Phe Val Ser Asp Leu Leu Pro Pro Thr Asp Lys Glu 
            340                 345                 350         


Leu Arg Glu Thr Ile Ala Leu Leu Thr Ala Gln Gln Thr Ala Leu Glu 
        355                 360                 365             


Ile Ile Val Asn Met Cys Cys Asn Glu Asp Pro Ser Asp Asp Glu Trp 
    370                 375                 380                 


Glu Glu Leu Ser Ser Ser Asp Glu Ser Asp Ala Phe Met Glu Asn Ser 
385                 390                 395                 400 


Phe Ser Glu Cys Gly Gly Gln Leu Phe Ser Pro Leu Cys Leu Ser His 
                405                 410                 415     


Glu Val His Thr Ala Leu Thr Asn Tyr Leu Ile Pro Lys Lys Ile Phe 
            420                 425                 430         


Glu Lys Thr Ala Phe Pro Asn Ser Ile Ala Val Asp Leu Cys Ser Arg 
        435                 440                 445             


Asn Pro Thr Trp Lys Pro Leu Ile Arg Lys Met Asn Thr Ile Gln Cys 
    450                 455                 460                 


Arg Ala Leu Phe Cys Leu Gln Ser Leu Val Ser Leu Leu Asp Val Glu 
465                 470                 475                 480 


His Leu Gly Gly Ala Ala Ala Leu Gln Thr Leu Ala Gln His Leu Ser 
                485                 490                 495     


Gln Leu Leu Phe Ser Gln Pro Asp Phe Ala Lys His Val Asp Phe Leu 
            500                 505                 510         


Glu Ala Ile Ser Ser Ala Leu Arg Ala Leu Leu Gln Thr Met Ala Ser 
        515                 520                 525             


Lys Asn Ile Ser Gln Cys Met Thr Pro Asp Gln Leu Met Thr Leu Cys 
    530                 535                 540                 


Lys Ala Gly Ile His Ser Ser Asn Val Gly Val Arg Val Asn Val Val 
545                 550                 555                 560 


Ser Ile Leu Gly Ile Thr Gly Ser Val Leu Ala Lys Glu Asp Gly Thr 
                565                 570                 575     


Leu Glu Thr Leu Lys Asn Ile Gly Cys Phe Leu Leu Glu Val Thr Thr 
            580                 585                 590         


Lys Asp Pro Ser Leu Val Val Ala Gly Glu Ala Leu Asp Ala Leu Phe 
        595                 600                 605             


Asp Val Phe Ala Asp Gly Lys Glu Ala Glu Arg Ala Ser Ile Gln Ile 
    610                 615                 620                 


Lys Leu Leu Ser Ala Leu Lys Glu Phe Gln Pro Val Phe Lys Met Lys 
625                 630                 635                 640 


Ile Arg Lys Glu Gly Arg Gly Asn Tyr Ser Thr Asp Gln Leu Cys Val 
                645                 650                 655     


Leu Asp Asn Val Lys Met Asn Leu Arg Arg Phe Ile Ala Tyr Gln Glu 
            660                 665                 670         


Thr Val Glu Lys Arg Leu Thr Ser 
        675                 680 


<210>  3396
<211>  7589
<212>  DNA
<213>  Homosapiens

<400>  3396
ccagcggagg gcgggccgcg gggggcggcc gagcagacgg cggcggggtc gtgtacagcg     60

ggaccccgtg gaaacggagg aactacaacc agggagtcgt gggtctgcat gaagaaatca    120

gtgattttta tgaatacatg tctccaagac ctgaggagga gaagatgcgg atggaggtgg    180

tgaacaggat cgagagtgta attaaggagc tctggcccag cgctgacgtc cagatatttg    240

gaagttttaa aactggactt tatttaccta ctagtgacat cgacctagtg gtgtttggga    300

agtgggagaa cctacccctc tggactctgg aagaagctct tcggaaacac aaagtcgcag    360

atgaggattc ggtgaaagtt ttagacaaag caactgtacc tattattaaa ttaacagatt    420

cttttactga agtgaaagtt gatatcagct ttaatgtaca gaatggcgtg agagcagctg    480

acctcatcaa agattttacc aagaaatatc ctgtattgcc atacttggtt ttagtattga    540

aacaattcct attgcagagg gaccttaatg aagtatttac aggtggaatt ggttcttata    600

gtctcttttt aatggcagtc agtttccttc agttacatcc cagggaagat gcttgcatcc    660

ccaatacaaa ctatggtgtt ctcttaatag aattttttga attatatgga cgacacttca    720

attatttaaa gactggcatc cggataaagg atggtggttc atatgtggcc aaagatgaag    780

tacagaaaaa tatgctagat ggctacaggc catcaatgct ttatatcgaa gatcctttac    840

aaccaggtaa cgatgttgga aggagttcat atggggccat gcaagtgaag caggcctttg    900

attatgccta cgttgttttg agtcatgctg tatcaccaat agcaaagtac tatcccaaca    960

atgaaacaga aagcatacta ggtagaataa ttagagtaac agatgaagtt gccacatata   1020

gagattggat atcaaagcag tggggcttga agaatagacc tgagccttca tgcaatggaa   1080

atggtgttac cttgatagta gatactcagc agttagataa atgtaataat aatctatctg   1140

aagaaaatga agcccttgga aaatgtagaa gtaaaacctc ggaatctctt agtaaacact   1200

cttcaaactc ttcatcaggt ccagtgtcgt cctcttctgc cacacagtcc agctctagtg   1260

atgtagattc cgatgcaaca ccatgcaaaa ccccgaaaca gctgctttgc cgtccgtcca   1320

ctgggaaccg agtagggtcg caagatgtat ccttggagtc ctctcaggca gttgggaaaa   1380

tgcaaagcac ccaaaccact aacacatcca acagcaccaa caaatctcag catggatcag   1440

caaggctctt tcgttcttcc agcaaaggct tccaaggtac aactcaaaca agccatggtt   1500

ccttgatgac aaacaaacaa catcaaggca aatccaataa tcagtattac catggcaaaa   1560

agaggaaaca caagagggac gcgcccctct cagacctctg tagatagtca gcgctgcgcg   1620

gtggactgtc ttctctgtgc aatgatctca tgctcaggac agttgcgcag ggactcctgg   1680

gagatattca ggagcctcac actgttcaga cgttgactta gcaactgcgt tttttcccag   1740

ctcgccacag aatggatcat gaagactgac aactgcaaaa aaaacaaaac aaaacaaaaa   1800

aaaaagcaag caaaaaagag ggaaaaaaaa ggctgcttat ttgataagtc atatgctaca   1860

acagggtcat tttaagattt aaagcttgaa tgtaaaataa atatatttct cattggcttt   1920

atgcagagtt atagggaata gtattcagtg ttggtagggt gatagaaaca aaaaacagta   1980

tcagaggatg aggtggggaa ggaaaacaaa ggtatctgat aggaagtcca gattccaaag   2040

gggaaagtga tctgtgcatg tttttttttt aaatattttt gcatatattt accattttat   2100

tgtgtgtata tatagaagac catataggag attgatattt gtaatagtgg atttgttaat   2160

aatacttttt acataacatt actgtttaaa ttgtaaacag attttttctc aggattagtt   2220

tgaaaaataa tctaaattgt catcttaaca tccatatata gggaagtgat tagttctatt   2280

actcaatttg tttttctcag cattgaaatg acttaataga acccttgtgt cctgctgcaa   2340

aaatttttcc tctctaaaga aaaggtttat ggtggcaaat gatgtttatt ttattttgta   2400

aaaaaaaaaa aatgtactat gtacttttgt gtaaacactg aaaaatctct ggtcatctcc   2460

gagaattaac ttgcaactgt tttctatagt gctgtcgtct tgggcaatgg gcaattacat   2520

gactttgtgt ttgcttcctt tgcagtcttt tttttttccc cccatttctt cctaatagga   2580

aaaaaaaaaa aaaaaaggtc acccatgtct ggtctcattc ctgttgcagt gaaacttcga   2640

gttccacaga ctttgcatgc tggcttctct aaccctgtgt gctgcgtgtg cctgtttctc   2700

atctcttatt ctttttaaaa ttcatgctta actactgtgg gagaataact gtaaacagct   2760

ttaattaaat catacttata aaaaactatt ttcttatatt ccactctatg cttttggtat   2820

tgttgatctt tacaaattaa atggtctttg ataatggatc tattttgtat tgccttatta   2880

agaccaaata cttcttgtca tcccattctt tatcctcttc tttcatggaa ttgttatcgt   2940

taattaaaac ttttttaaac attggcttgt ttcaatcata ctgtaaattt tggttgtagt   3000

cagctttgag tgcaatgaga tgtataattc tgttatcatt acctgttgag tttgaaactc   3060

agttgggaat atttaatata atagaatgta agtgacattt ctgaaaatgc tttctttcag   3120

ggtgaaagct cttatgttta gcatcaatgt gtatggctct gttaaatgca gccatttctg   3180

agacgagatt cttttatata tatatacata taaagtacta ttggctttta ggagtttctt   3240

ttatatacat ttatgaaata ctgaagacca atcagaccat taatggacac ttagtgtaac   3300

tttttataaa gaaaataatg ctaaagtaag accaaaactg atgtcatcac tgaaattaac   3360

aattttcaat atgttcatat tttaattcac aatggaaaaa tgtgttccaa aactggaaac   3420

tcatagtact cgtgtaaact gtggaagatt tcaaatgtga tgttattttg acaatgtttt   3480

aaattttaga gtcacatttt attctgatca gaatttttat tgagatgttg agcttttgtt   3540

tttgaaacta gtttgtcata acattgtgca taatcacagt atttattttc taggacaatt   3600

gtgaatgtgt agacttatgt ttactgctaa gggaacaatt atttataaaa taatattaaa   3660

tccagtatta gctgcctatt tcagacactt aatacttgca gagatctatg ttacatttac   3720

cacactgaag ttttttttgt tgttttttgt ttgtttttaa agaatcaccc tcattgttga   3780

aagtaaatgt actcttaggg tgcgaatatt agtgttccaa taagcatgtg attatattaa   3840

ggtggtggta gcgggaagat aattctgatt ccattgggaa tcttaggttt tcgtaaattt   3900

attgggaaaa tagtttttcc tgtactgctg aagtttcttt ttggtaaaca gtatctttct   3960

aaaagaaaaa agcatgaagg agaaattgag gtgtgtatac atttcctcaa atgaccagca   4020

ttgtattcgt gaatactgtg tatcttgcag tgaacagtgt ggaagctgtt catttttcaa   4080

tctgaagtaa aatactttca agaactttta gtttgcctgc tcatttgttt tatacatttc   4140

atctatttga ctcctatctt atttcttttt tgagttttaa tacttcctat attttgtgaa   4200

tatatcagaa atgtgtcatt tatatattag agtccattca tatccatgaa tcataacctt   4260

cctttgctaa tacttgttga atgggatttt acaaattctc cctcactctg gtgacatttc   4320

tcaggcagtc atgtatgtgt acctggccat tagaaatatt aatatttaaa gactgttttt   4380

tagaggagct gatgggttgg tgaggtgtca gcacaaaatc ttactggtta tgttttgatg   4440

ataaaagtat atccattttt tccctccagc tttaaggtga ctgtgaaggt gcctggtttt   4500

gaatgtcttt gtttggtttg gagatgtcgc actcagtttt caaatctagc ttggatctgt   4560

aggacctatg ttttttacaa gtaattgccc tccagtcttc aacagttgat tctgttttat   4620

ttttatcctg ttttgagtgt actttacctt tacttgcatt ttgagcctca ttaatattta   4680

ggttatttga tttggctcca gatattccta gatctgcaca gggcaaaaca tgggctatag   4740

ggtgagcatt tttaattgtc tttttctgct ggaaccttat atctctccat gtgttttctg   4800

ctccttccct cccccatgaa atggtaagtg tgacttgtgt ttgcctgaac ctgtggacta   4860

gtgtttgggg tttctggaaa cactagaggg tcagaaaaga gtaatgacca ccgtgacgtg   4920

caggattctc ttgctgtgac atgttcattg caaagccctc tccagtgact aggaggtgta   4980

gttattaagg ttgatctgtt agaaatcacc attattaggt attagtggta gatgttgctg   5040

atacttttat tggtcatgac tacatctcag ttttacttta atattgatct atagtttgat   5100

cagttccttg aattctaata tgttgatttc tcagtgtttc tgtcactaac caagaatgtt   5160

tctaggcagt tggttgcttc acagtcaaaa ctaaatggta aactatcaaa aatacattcc   5220

caattttgct gtgataaata ttgaaatgtt aaaattaatg aacagaagaa tttattctta   5280

cccatctatt cttgttctcc tagttcatta aactttcagt tattggaaag gcacattctc   5340

aaagtatttt atgagcaaaa tattctataa atgcgtctaa caaacctaat tgaatataaa   5400

agttatattt agtagttact gttgatagta attttcatca gggtcatagt tcatctagta   5460

aaatatttag agaatgatgt taacattcca gcattaaagt gggaacaaag atttatatat   5520

gaaattcctt aaaagagttc atcttgcctt ggtttctgac cctcaagact ctagctacct   5580

gccatcttgt caaaacattt gtgggtagaa taagtgttaa agatcaaatt ttaatatgct   5640

tctcgatatt taacatagct aagaagccag attttactgt agaagttatt tacatgattt   5700

gaaaacttga cctaactgga agcctttttc tcagtcatct tgttctaagc catcttgact   5760

tcacaccctt agcgactttt cttttttttt tggtcaaaga taatgagcta aatatatata   5820

gacgttgaat gttgacaaaa ttattaacca gaaaaattgc ttataaaggc tgctgatcta   5880

tttgatacct agaattaaat atttgaggac agtttttagt taataaactg ctaatgttta   5940

ttttactgtc tctcaggttt ttggtttttt taaaaaaaat gtgtttggcc tttacatttt   6000

ctacttaagt gtgtacttta ttgagtttaa ccttgtctgt agcctagtag cctgaaagaa   6060

aaggagacag aaccagagag atggatgtag tgcattccct ttggttatta cacatttgtg   6120

gtagctcctg gatttactga gagatatttt agctatgtca ataagaacag ctaatgatgt   6180

ggaaatcagg tgttctcttg tgtatttcag tgaacatttt tattagtagt tgcatatcat   6240

ctctagttcc acattttaac ttaacgtctt tgtggcttca ccactgagct acctttcact   6300

acaccagctt ctgtgtggcc tggtaacatg gaaggtctct cctaaggaca gtctggacgt   6360

attttggggg aatgttattt atcttaaaga tgcctagaaa caaaacgcat atagtaccag   6420

tgagaaacta tgaagtaaac aagttgctca ggccgggcat ggtggctcac gcctgtaatc   6480

ccagcacttt gggaggccga agcgggagga tggcttgagg ctgggagttt gagaccttca   6540

tctcttaaaa aaacaaacaa aaacctgaat ggtgaggtgt ggtggaattg ggtaggggag   6600

ggaaaggagg acttggaaaa gcattctcca aagccagcaa cttggtgaag ttcagtactt   6660

gcctcttaga ggttaggcca tgcctttcaa agagagtgaa atgatgggtt atcagccaca   6720

ttcttggagt taatattttt cttcatcttt cagtttgggt tctgtgctat tcatagttct   6780

tccctaagac catttcatta ttacctttta tatttagttg caatttatta taatatgttg   6840

ttttgtccct gaacttaatc tcctaatttt aagatcctct ctgatttttg catattgaaa   6900

cttacagaag tcactttaaa aaagtctttt gaaagtccta caatcctaaa ataaatcaca   6960

agcttgtttg ttagacgtgt caagagtctc cagtctttac tactaaaaag cagcactgcc   7020

ttaacacaca ttgttatggg tgaaaagtga gggacgacca gtgtagtttc tggatataaa   7080

gtgtgaagga ctgttgagtt aaacattttt agtggaatat acatagataa cgtgtattta   7140

gaaactttgg tgaagccagt atttgttttt agtaaccttt ttatgtattt ccttctttga   7200

ttagcattgt cttcagtgtt aagaaatgtg gactcctgtg aggtgctgga ggtttgaatc   7260

atcttgaaaa ctttccaatc ttgtctagtt accactgcag agacactaag gaatttacca   7320

gaaaaagata tttgatacaa gtgatttaag aaatctcaac atttcctgag gccgtatcac   7380

tgggcaacca gtgatgaaaa ctatgaatga attgcacacc tggaagattt tttaagctaa   7440

tgacagtttc ttcaaagatg tcaattattt gccttggaaa ttttataaat tgcatttcta   7500

tgcacatcgg cctctagtgc ttaccactcg gtttattatt cataatctgc aattcaataa   7560

aggctttgtg ttttcattta tcttcaaaa                                     7589


<210>  3397
<211>  489
<212>  PRT
<213>  Homosapiens

<400>  3397

Met Ser Pro Arg Pro Glu Glu Glu Lys Met Arg Met Glu Val Val Asn 
1               5                   10                  15      


Arg Ile Glu Ser Val Ile Lys Glu Leu Trp Pro Ser Ala Asp Val Gln 
            20                  25                  30          


Ile Phe Gly Ser Phe Lys Thr Gly Leu Tyr Leu Pro Thr Ser Asp Ile 
        35                  40                  45              


Asp Leu Val Val Phe Gly Lys Trp Glu Asn Leu Pro Leu Trp Thr Leu 
    50                  55                  60                  


Glu Glu Ala Leu Arg Lys His Lys Val Ala Asp Glu Asp Ser Val Lys 
65                  70                  75                  80  


Val Leu Asp Lys Ala Thr Val Pro Ile Ile Lys Leu Thr Asp Ser Phe 
                85                  90                  95      


Thr Glu Val Lys Val Asp Ile Ser Phe Asn Val Gln Asn Gly Val Arg 
            100                 105                 110         


Ala Ala Asp Leu Ile Lys Asp Phe Thr Lys Lys Tyr Pro Val Leu Pro 
        115                 120                 125             


Tyr Leu Val Leu Val Leu Lys Gln Phe Leu Leu Gln Arg Asp Leu Asn 
    130                 135                 140                 


Glu Val Phe Thr Gly Gly Ile Gly Ser Tyr Ser Leu Phe Leu Met Ala 
145                 150                 155                 160 


Val Ser Phe Leu Gln Leu His Pro Arg Glu Asp Ala Cys Ile Pro Asn 
                165                 170                 175     


Thr Asn Tyr Gly Val Leu Leu Ile Glu Phe Phe Glu Leu Tyr Gly Arg 
            180                 185                 190         


His Phe Asn Tyr Leu Lys Thr Gly Ile Arg Ile Lys Asp Gly Gly Ser 
        195                 200                 205             


Tyr Val Ala Lys Asp Glu Val Gln Lys Asn Met Leu Asp Gly Tyr Arg 
    210                 215                 220                 


Pro Ser Met Leu Tyr Ile Glu Asp Pro Leu Gln Pro Gly Asn Asp Val 
225                 230                 235                 240 


Gly Arg Ser Ser Tyr Gly Ala Met Gln Val Lys Gln Ala Phe Asp Tyr 
                245                 250                 255     


Ala Tyr Val Val Leu Ser His Ala Val Ser Pro Ile Ala Lys Tyr Tyr 
            260                 265                 270         


Pro Asn Asn Glu Thr Glu Ser Ile Leu Gly Arg Ile Ile Arg Val Thr 
        275                 280                 285             


Asp Glu Val Ala Thr Tyr Arg Asp Trp Ile Ser Lys Gln Trp Gly Leu 
    290                 295                 300                 


Lys Asn Arg Pro Glu Pro Ser Cys Asn Gly Asn Gly Val Thr Leu Ile 
305                 310                 315                 320 


Val Asp Thr Gln Gln Leu Asp Lys Cys Asn Asn Asn Leu Ser Glu Glu 
                325                 330                 335     


Asn Glu Ala Leu Gly Lys Cys Arg Ser Lys Thr Ser Glu Ser Leu Ser 
            340                 345                 350         


Lys His Ser Ser Asn Ser Ser Ser Gly Pro Val Ser Ser Ser Ser Ala 
        355                 360                 365             


Thr Gln Ser Ser Ser Ser Asp Val Asp Ser Asp Ala Thr Pro Cys Lys 
    370                 375                 380                 


Thr Pro Lys Gln Leu Leu Cys Arg Pro Ser Thr Gly Asn Arg Val Gly 
385                 390                 395                 400 


Ser Gln Asp Val Ser Leu Glu Ser Ser Gln Ala Val Gly Lys Met Gln 
                405                 410                 415     


Ser Thr Gln Thr Thr Asn Thr Ser Asn Ser Thr Asn Lys Ser Gln His 
            420                 425                 430         


Gly Ser Ala Arg Leu Phe Arg Ser Ser Ser Lys Gly Phe Gln Gly Thr 
        435                 440                 445             


Thr Gln Thr Ser His Gly Ser Leu Met Thr Asn Lys Gln His Gln Gly 
    450                 455                 460                 


Lys Ser Asn Asn Gln Tyr Tyr His Gly Lys Lys Arg Lys His Lys Arg 
465                 470                 475                 480 


Asp Ala Pro Leu Ser Asp Leu Cys Arg 
                485                 


<210>  3398
<211>  7448
<212>  DNA
<213>  Homosapiens

<400>  3398
ccagcggagg gcgggccgcg gggggcggcc gagcagacgg cggcggggtc gtgtacagcg     60

ggaccccgtg gaaacggagg aactacaacc agggagtcgt gggtctgcat gaagaaatca    120

gtgattttta tgaatacatg tctccaagac ctgaggagga gaagatgcgg atggaggtgg    180

tgaacaggat cgagagtgta attaaggagc tctggcccag cgctgacgtc cagatatttg    240

gaagttttaa aactggactt tatttaccta ctagtgacat cgacctagtg gtgtttggga    300

agtgggagaa cctacccctc tggactctgg aagaagctct tcggaaacac aaagtcgcag    360

atgaggattc ggtgaaagtt ttagacaaag caactgtacc tattattaaa ttaacagatt    420

cttttactga agtgaaagtt gatatcagct ttaatgtaca gaatggcgtg agagcagctg    480

acctcatcaa agattttacc aagaaatatc ctgtattgcc atacttggtt ttagtattga    540

aacaattcct attgcagagg gaccttaatg aagtatttac aggtggaatt ggttcttata    600

gtctcttttt aatggcagtc agtttccttc agttacatcc cagggaagat gcttgcatcc    660

ccaatacaaa ctatggtgtt ctcttaatag aattttttga attatatgga cgacacttca    720

attatttaaa gactggcatc cggataaagg atggtggttc atatgtggcc aaagatgaag    780

tacagaaaaa tatgctagat ggctacaggc catcaatgct ttatatcgaa gatcctttac    840

aaccaggtaa cgatgttgga aggagttcat atggggccat gcaagtgaag caggcctttg    900

attatgccta cgttgttttg agtcatgctg tatcaccaat agcaaagtac tatcccaaca    960

atgaaacaga aagcatacta ggtagaataa ttagagtaac agatgaagtt gccacatata   1020

gagattggat atcaaagcag tggggcttga agaatagacc tgagccttca tgcaatggtc   1080

cagtgtcgtc ctcttctgcc acacagtcca gctctagtga tgtagattcc gatgcaacac   1140

catgcaaaac cccgaaacag ctgctttgcc gtccgtccac tgggaaccga gtagggtcgc   1200

aagatgtatc cttggagtcc tctcaggcag ttgggaaaat gcaaagcacc caaaccacta   1260

acacatccaa cagcaccaac aaatctcagc atggatcagc aaggctcttt cgttcttcca   1320

gcaaaggctt ccaaggtaca actcaaacaa gccatggttc cttgatgaca aacaaacaac   1380

atcaaggcaa atccaataat cagtattacc atggcaaaaa gaggaaacac aagagggacg   1440

cgcccctctc agacctctgt agatagtcag cgctgcgcgg tggactgtct tctctgtgca   1500

atgatctcat gctcaggaca gttgcgcagg gactcctggg agatattcag gagcctcaca   1560

ctgttcagac gttgacttag caactgcgtt ttttcccagc tcgccacaga atggatcatg   1620

aagactgaca actgcaaaaa aaacaaaaca aaacaaaaaa aaaagcaagc aaaaaagagg   1680

gaaaaaaaag gctgcttatt tgataagtca tatgctacaa cagggtcatt ttaagattta   1740

aagcttgaat gtaaaataaa tatatttctc attggcttta tgcagagtta tagggaatag   1800

tattcagtgt tggtagggtg atagaaacaa aaaacagtat cagaggatga ggtggggaag   1860

gaaaacaaag gtatctgata ggaagtccag attccaaagg ggaaagtgat ctgtgcatgt   1920

ttttttttta aatatttttg catatattta ccattttatt gtgtgtatat atagaagacc   1980

atataggaga ttgatatttg taatagtgga tttgttaata atacttttta cataacatta   2040

ctgtttaaat tgtaaacaga ttttttctca ggattagttt gaaaaataat ctaaattgtc   2100

atcttaacat ccatatatag ggaagtgatt agttctatta ctcaatttgt ttttctcagc   2160

attgaaatga cttaatagaa cccttgtgtc ctgctgcaaa aatttttcct ctctaaagaa   2220

aaggtttatg gtggcaaatg atgtttattt tattttgtaa aaaaaaaaaa atgtactatg   2280

tacttttgtg taaacactga aaaatctctg gtcatctccg agaattaact tgcaactgtt   2340

ttctatagtg ctgtcgtctt gggcaatggg caattacatg actttgtgtt tgcttccttt   2400

gcagtctttt ttttttcccc ccatttcttc ctaataggaa aaaaaaaaaa aaaaaggtca   2460

cccatgtctg gtctcattcc tgttgcagtg aaacttcgag ttccacagac tttgcatgct   2520

ggcttctcta accctgtgtg ctgcgtgtgc ctgtttctca tctcttattc tttttaaaat   2580

tcatgcttaa ctactgtggg agaataactg taaacagctt taattaaatc atacttataa   2640

aaaactattt tcttatattc cactctatgc ttttggtatt gttgatcttt acaaattaaa   2700

tggtctttga taatggatct attttgtatt gccttattaa gaccaaatac ttcttgtcat   2760

cccattcttt atcctcttct ttcatggaat tgttatcgtt aattaaaact tttttaaaca   2820

ttggcttgtt tcaatcatac tgtaaatttt ggttgtagtc agctttgagt gcaatgagat   2880

gtataattct gttatcatta cctgttgagt ttgaaactca gttgggaata tttaatataa   2940

tagaatgtaa gtgacatttc tgaaaatgct ttctttcagg gtgaaagctc ttatgtttag   3000

catcaatgtg tatggctctg ttaaatgcag ccatttctga gacgagattc ttttatatat   3060

atatacatat aaagtactat tggcttttag gagtttcttt tatatacatt tatgaaatac   3120

tgaagaccaa tcagaccatt aatggacact tagtgtaact ttttataaag aaaataatgc   3180

taaagtaaga ccaaaactga tgtcatcact gaaattaaca attttcaata tgttcatatt   3240

ttaattcaca atggaaaaat gtgttccaaa actggaaact catagtactc gtgtaaactg   3300

tggaagattt caaatgtgat gttattttga caatgtttta aattttagag tcacatttta   3360

ttctgatcag aatttttatt gagatgttga gcttttgttt ttgaaactag tttgtcataa   3420

cattgtgcat aatcacagta tttattttct aggacaattg tgaatgtgta gacttatgtt   3480

tactgctaag ggaacaatta tttataaaat aatattaaat ccagtattag ctgcctattt   3540

cagacactta atacttgcag agatctatgt tacatttacc acactgaagt tttttttgtt   3600

gttttttgtt tgtttttaaa gaatcaccct cattgttgaa agtaaatgta ctcttagggt   3660

gcgaatatta gtgttccaat aagcatgtga ttatattaag gtggtggtag cgggaagata   3720

attctgattc cattgggaat cttaggtttt cgtaaattta ttgggaaaat agtttttcct   3780

gtactgctga agtttctttt tggtaaacag tatctttcta aaagaaaaaa gcatgaagga   3840

gaaattgagg tgtgtataca tttcctcaaa tgaccagcat tgtattcgtg aatactgtgt   3900

atcttgcagt gaacagtgtg gaagctgttc atttttcaat ctgaagtaaa atactttcaa   3960

gaacttttag tttgcctgct catttgtttt atacatttca tctatttgac tcctatctta   4020

tttctttttt gagttttaat acttcctata ttttgtgaat atatcagaaa tgtgtcattt   4080

atatattaga gtccattcat atccatgaat cataaccttc ctttgctaat acttgttgaa   4140

tgggatttta caaattctcc ctcactctgg tgacatttct caggcagtca tgtatgtgta   4200

cctggccatt agaaatatta atatttaaag actgtttttt agaggagctg atgggttggt   4260

gaggtgtcag cacaaaatct tactggttat gttttgatga taaaagtata tccatttttt   4320

ccctccagct ttaaggtgac tgtgaaggtg cctggttttg aatgtctttg tttggtttgg   4380

agatgtcgca ctcagttttc aaatctagct tggatctgta ggacctatgt tttttacaag   4440

taattgccct ccagtcttca acagttgatt ctgttttatt tttatcctgt tttgagtgta   4500

ctttaccttt acttgcattt tgagcctcat taatatttag gttatttgat ttggctccag   4560

atattcctag atctgcacag ggcaaaacat gggctatagg gtgagcattt ttaattgtct   4620

ttttctgctg gaaccttata tctctccatg tgttttctgc tccttccctc ccccatgaaa   4680

tggtaagtgt gacttgtgtt tgcctgaacc tgtggactag tgtttggggt ttctggaaac   4740

actagagggt cagaaaagag taatgaccac cgtgacgtgc aggattctct tgctgtgaca   4800

tgttcattgc aaagccctct ccagtgacta ggaggtgtag ttattaaggt tgatctgtta   4860

gaaatcacca ttattaggta ttagtggtag atgttgctga tacttttatt ggtcatgact   4920

acatctcagt tttactttaa tattgatcta tagtttgatc agttccttga attctaatat   4980

gttgatttct cagtgtttct gtcactaacc aagaatgttt ctaggcagtt ggttgcttca   5040

cagtcaaaac taaatggtaa actatcaaaa atacattccc aattttgctg tgataaatat   5100

tgaaatgtta aaattaatga acagaagaat ttattcttac ccatctattc ttgttctcct   5160

agttcattaa actttcagtt attggaaagg cacattctca aagtatttta tgagcaaaat   5220

attctataaa tgcgtctaac aaacctaatt gaatataaaa gttatattta gtagttactg   5280

ttgatagtaa ttttcatcag ggtcatagtt catctagtaa aatatttaga gaatgatgtt   5340

aacattccag cattaaagtg ggaacaaaga tttatatatg aaattcctta aaagagttca   5400

tcttgccttg gtttctgacc ctcaagactc tagctacctg ccatcttgtc aaaacatttg   5460

tgggtagaat aagtgttaaa gatcaaattt taatatgctt ctcgatattt aacatagcta   5520

agaagccaga ttttactgta gaagttattt acatgatttg aaaacttgac ctaactggaa   5580

gcctttttct cagtcatctt gttctaagcc atcttgactt cacaccctta gcgacttttc   5640

tttttttttt ggtcaaagat aatgagctaa atatatatag acgttgaatg ttgacaaaat   5700

tattaaccag aaaaattgct tataaaggct gctgatctat ttgataccta gaattaaata   5760

tttgaggaca gtttttagtt aataaactgc taatgtttat tttactgtct ctcaggtttt   5820

tggttttttt aaaaaaaatg tgtttggcct ttacattttc tacttaagtg tgtactttat   5880

tgagtttaac cttgtctgta gcctagtagc ctgaaagaaa aggagacaga accagagaga   5940

tggatgtagt gcattccctt tggttattac acatttgtgg tagctcctgg atttactgag   6000

agatatttta gctatgtcaa taagaacagc taatgatgtg gaaatcaggt gttctcttgt   6060

gtatttcagt gaacattttt attagtagtt gcatatcatc tctagttcca cattttaact   6120

taacgtcttt gtggcttcac cactgagcta cctttcacta caccagcttc tgtgtggcct   6180

ggtaacatgg aaggtctctc ctaaggacag tctggacgta ttttggggga atgttattta   6240

tcttaaagat gcctagaaac aaaacgcata tagtaccagt gagaaactat gaagtaaaca   6300

agttgctcag gccgggcatg gtggctcacg cctgtaatcc cagcactttg ggaggccgaa   6360

gcgggaggat ggcttgaggc tgggagtttg agaccttcat ctcttaaaaa aacaaacaaa   6420

aacctgaatg gtgaggtgtg gtggaattgg gtaggggagg gaaaggagga cttggaaaag   6480

cattctccaa agccagcaac ttggtgaagt tcagtacttg cctcttagag gttaggccat   6540

gcctttcaaa gagagtgaaa tgatgggtta tcagccacat tcttggagtt aatatttttc   6600

ttcatctttc agtttgggtt ctgtgctatt catagttctt ccctaagacc atttcattat   6660

taccttttat atttagttgc aatttattat aatatgttgt tttgtccctg aacttaatct   6720

cctaatttta agatcctctc tgatttttgc atattgaaac ttacagaagt cactttaaaa   6780

aagtcttttg aaagtcctac aatcctaaaa taaatcacaa gcttgtttgt tagacgtgtc   6840

aagagtctcc agtctttact actaaaaagc agcactgcct taacacacat tgttatgggt   6900

gaaaagtgag ggacgaccag tgtagtttct ggatataaag tgtgaaggac tgttgagtta   6960

aacattttta gtggaatata catagataac gtgtatttag aaactttggt gaagccagta   7020

tttgttttta gtaacctttt tatgtatttc cttctttgat tagcattgtc ttcagtgtta   7080

agaaatgtgg actcctgtga ggtgctggag gtttgaatca tcttgaaaac tttccaatct   7140

tgtctagtta ccactgcaga gacactaagg aatttaccag aaaaagatat ttgatacaag   7200

tgatttaaga aatctcaaca tttcctgagg ccgtatcact gggcaaccag tgatgaaaac   7260

tatgaatgaa ttgcacacct ggaagatttt ttaagctaat gacagtttct tcaaagatgt   7320

caattatttg ccttggaaat tttataaatt gcatttctat gcacatcggc ctctagtgct   7380

taccactcgg tttattattc ataatctgca attcaataaa ggctttgtgt tttcatttat   7440

cttcaaaa                                                            7448


<210>  3399
<211>  442
<212>  PRT
<213>  Homosapiens

<400>  3399

Met Ser Pro Arg Pro Glu Glu Glu Lys Met Arg Met Glu Val Val Asn 
1               5                   10                  15      


Arg Ile Glu Ser Val Ile Lys Glu Leu Trp Pro Ser Ala Asp Val Gln 
            20                  25                  30          


Ile Phe Gly Ser Phe Lys Thr Gly Leu Tyr Leu Pro Thr Ser Asp Ile 
        35                  40                  45              


Asp Leu Val Val Phe Gly Lys Trp Glu Asn Leu Pro Leu Trp Thr Leu 
    50                  55                  60                  


Glu Glu Ala Leu Arg Lys His Lys Val Ala Asp Glu Asp Ser Val Lys 
65                  70                  75                  80  


Val Leu Asp Lys Ala Thr Val Pro Ile Ile Lys Leu Thr Asp Ser Phe 
                85                  90                  95      


Thr Glu Val Lys Val Asp Ile Ser Phe Asn Val Gln Asn Gly Val Arg 
            100                 105                 110         


Ala Ala Asp Leu Ile Lys Asp Phe Thr Lys Lys Tyr Pro Val Leu Pro 
        115                 120                 125             


Tyr Leu Val Leu Val Leu Lys Gln Phe Leu Leu Gln Arg Asp Leu Asn 
    130                 135                 140                 


Glu Val Phe Thr Gly Gly Ile Gly Ser Tyr Ser Leu Phe Leu Met Ala 
145                 150                 155                 160 


Val Ser Phe Leu Gln Leu His Pro Arg Glu Asp Ala Cys Ile Pro Asn 
                165                 170                 175     


Thr Asn Tyr Gly Val Leu Leu Ile Glu Phe Phe Glu Leu Tyr Gly Arg 
            180                 185                 190         


His Phe Asn Tyr Leu Lys Thr Gly Ile Arg Ile Lys Asp Gly Gly Ser 
        195                 200                 205             


Tyr Val Ala Lys Asp Glu Val Gln Lys Asn Met Leu Asp Gly Tyr Arg 
    210                 215                 220                 


Pro Ser Met Leu Tyr Ile Glu Asp Pro Leu Gln Pro Gly Asn Asp Val 
225                 230                 235                 240 


Gly Arg Ser Ser Tyr Gly Ala Met Gln Val Lys Gln Ala Phe Asp Tyr 
                245                 250                 255     


Ala Tyr Val Val Leu Ser His Ala Val Ser Pro Ile Ala Lys Tyr Tyr 
            260                 265                 270         


Pro Asn Asn Glu Thr Glu Ser Ile Leu Gly Arg Ile Ile Arg Val Thr 
        275                 280                 285             


Asp Glu Val Ala Thr Tyr Arg Asp Trp Ile Ser Lys Gln Trp Gly Leu 
    290                 295                 300                 


Lys Asn Arg Pro Glu Pro Ser Cys Asn Gly Pro Val Ser Ser Ser Ser 
305                 310                 315                 320 


Ala Thr Gln Ser Ser Ser Ser Asp Val Asp Ser Asp Ala Thr Pro Cys 
                325                 330                 335     


Lys Thr Pro Lys Gln Leu Leu Cys Arg Pro Ser Thr Gly Asn Arg Val 
            340                 345                 350         


Gly Ser Gln Asp Val Ser Leu Glu Ser Ser Gln Ala Val Gly Lys Met 
        355                 360                 365             


Gln Ser Thr Gln Thr Thr Asn Thr Ser Asn Ser Thr Asn Lys Ser Gln 
    370                 375                 380                 


His Gly Ser Ala Arg Leu Phe Arg Ser Ser Ser Lys Gly Phe Gln Gly 
385                 390                 395                 400 


Thr Thr Gln Thr Ser His Gly Ser Leu Met Thr Asn Lys Gln His Gln 
                405                 410                 415     


Gly Lys Ser Asn Asn Gln Tyr Tyr His Gly Lys Lys Arg Lys His Lys 
            420                 425                 430         


Arg Asp Ala Pro Leu Ser Asp Leu Cys Arg 
        435                 440         


<210>  3400
<211>  433
<212>  DNA
<213>  Homosapiens

<400>  3400
tcaacataca agttgaccat ggcatgctct gggctccagt cctctacaaa gatgtagggc     60

aggaactacc agttgtcagc acagcaccat cccacattgc tcttctaatg gagactttca    120

ccccagatgt tctttctcgt ctgatgggaa ggatccaaat gaaaaaattg aggctcaaag    180

aagtccacca aattgagagt gaagtagggg aaacagcatt taacgcttac attctaatga    240

tttgtgtaag agcagcagga caagctatac aaagaaaaag gtggaattat caggatggaa    300

ttaaagatgc ttccaaacag aggggatatc tcaagccatg actcagagag atccaatcga    360

gtaccaggtc cagcggtaat ctattcgcag atgtagtgga acatctcaga agaataaaaa    420

agaaaataac cta                                                       433


<210>  3401
<211>  105
<212>  PRT
<213>  Homosapiens

<400>  3401

Met Leu Trp Ala Pro Val Leu Tyr Lys Asp Val Gly Gln Glu Leu Pro 
1               5                   10                  15      


Val Val Ser Thr Ala Pro Ser His Ile Ala Leu Leu Met Glu Thr Phe 
            20                  25                  30          


Thr Pro Asp Val Leu Ser Arg Leu Met Gly Arg Ile Gln Met Lys Lys 
        35                  40                  45              


Leu Arg Leu Lys Glu Val His Gln Ile Glu Ser Glu Val Gly Glu Thr 
    50                  55                  60                  


Ala Phe Asn Ala Tyr Ile Leu Met Ile Cys Val Arg Ala Ala Gly Gln 
65                  70                  75                  80  


Ala Ile Gln Arg Lys Arg Trp Asn Tyr Gln Asp Gly Ile Lys Asp Ala 
                85                  90                  95      


Ser Lys Gln Arg Gly Tyr Leu Lys Pro 
            100                 105 


<210>  3402
<211>  3678
<212>  DNA
<213>  Homosapiens

<400>  3402
cggggctgat tctctggctg tgtggggcgc acggtcccgg gatactgggg acggcggggt     60

gggagggcgc cgtcctgggg ccgcggcggc cgggcggggg agatggcggc gcgatggagc    120

agcgaaaacg tggttgtaga gttccgtgac tcccaggcaa ctgcgatgtc tgtggactgt    180

cttgggcagc atgcagtgct ttctggccgc agattcttat acatcgtcaa tctagatgcc    240

cctttcgaag gtcaccgaaa gatctctcgc cagagcaaat gggacattgg agctgtgcag    300

tggaatcctc atgacagctt tgcacactat tttgcggctt cgagtaacca acgagtagac    360

ctttacaagt ggaaagacgg cagtggggaa gttggcacaa ccttacaagg ccacactcgt    420

gtcatcagcg acttggactg ggcggtgttt gagcctgacc tcctggttac cagctctgtg    480

gacacctaca tctacatttg ggatatcaaa gacacaagga aacctactgt tgcactgtct    540

gctgttgcgg gtgcctccca ggtcaaatgg aataaaaaaa atgctaactg ccttgccacc    600

agccatgacg gcgatgtgcg gatatgggat aagaggaaac ccagtacagc agtggaatat    660

ctagccgccc acctctccaa aatccatggc ctggactggc acccagacag cgagcacatt    720

cttgctacct ccagtcaaga caattctgtg aagttctggg attaccgcca gcctcggaaa    780

tacctcaata ttcttccttg ccaggtgcct gtctggaagg ccagatacac acctttcagc    840

aatggattgg tgactgtgat ggttccccag ctgcggaggg aaaacagcct tctcctgtgg    900

aatgtctttg acttgaacac cccagtccac accttcgtgg ggcatgatga tgtggtcctg    960

gagttccagt ggaggaagca gaaggaaggg tccaaggact atcaactggt gacgtggtcc   1020

cgggatcaga ccttgagaat gtggcgggtg gattcccaga tgcagaggct ttgtgcaaat   1080

gacatattag atggtgttga tgagttcatt gagagtattt cccttctgcc ggaacctgag   1140

aagaccctgc acactgaaga tacagatcac cagcacactg caagccatgg ggaggaagaa   1200

gccctaaaag aagatccccc tagaaatctc ctggaagaga ggaaatcaga tcaactgggg   1260

ctgcctcaga ccttgcagca ggaattctcc ctgatcaatg tgcaaatccg gaatgtcaat   1320

gtggagatgg atgcggcaga caggagctgc acagtgtctg tgcactgcag caaccatcgt   1380

gtcaagatgc tggtgaagtt ccctgcacag tacccaaaca acgccgcccc ttccttccag   1440

tttattaacc ccacaaccat cacatccacc atgaaagcta agctgctgaa gatcctgaag   1500

gacacagccc tgcagaaagt gaagcgtggc cagagctgcc tggagccctg cctgcgccag   1560

ctcgtctcct gccttgagtc ctttgtgaac caggaagaca gcgcttccag caacccgttt   1620

gcactcccca actctgtcac tcccccctta ccgacgtttg cgcgggtgac cacggcttac   1680

gggtcgtacc aggacgccaa cattcccttt cctaggactt ctggggccag gttctgcgga   1740

gcaggttacc tggtatattt cacaaggccc atgacaatgc atcgggcggt gtctcccaca   1800

gagcctactc cgagatctct ctcagccttg tctgcttatc acactggctt gatcgcgccc   1860

atgaagatcc gcacagaggc ccctgggaac cttcgtttat acagtgggag ccccactcgc   1920

agcgagaaag agcaggtctc catcagctcc ttctactaca aggagcggaa atcaagacga   1980

tggaaaagta agcgtgaggg atcagactct ggcaatcgac agatcaaggc tgctgggaaa   2040

gtcatcatcc aggatattgc ttgcctcctg cctgttcaca aatcgctggg agagctgtac   2100

atattgaatg tgaatgatat tcaggaaaca tgtcagaaga atgccgcctc tgccttgctc   2160

gttggaagaa aggatcttgt ccaggtttgg tcgctggcta cggtagctac agatctttgc   2220

cttggtccga aatctgaccc agatttggaa acaccctggg ctcgacatcc atttgggcgg   2280

cagctgctgg agtccctgtt ggctcactat tgccggctcc gggatgttca gacactggcg   2340

atgctctgta gcgtgtttga agcccagtct cggcctcagg ggctaccaaa cccctttggg   2400

ccttttccta accgttcttc taatcttgtg gtgtcccata gtcgatatcc tagctttacc   2460

tcttctggtt cctgctccag tatgtcagac ccagggctca acactggcgg ctggaacata   2520

gcgggaagag aggcagagca cttgtcctcc ccttggggag aatcctcacc agaagagctc   2580

cgctttggga gtctgaccta cagtgatccc cgtgagcgag aacgcgacca gcatgataaa   2640

aataaaaggc tcctggaccc cgccaatacc cagcaatttg atgactttaa gaaatgctat   2700

ggggaaatcc tctaccgttg gggtctgaga gagaagcgag ctgaagtgtt gaagtttgtc   2760

tcctgtcctc ctgaccctca caaagggatc gagttcggcg tgtactgcag ccactgccgg   2820

agtgaggtcc gtggcacgca gtgtgccatc tgcaaaggct tcacgttcca gtgtgccatc   2880

tgtcacgtgg ctgtgcgggg atcgtccaat ttctgcctga cctgtgggca cggtggccac   2940

accagccaca tgatggagtg gtttcggacc caggaggtgt gtcccaccgg gtgtgggtgc   3000

cactgcctgc ttgaaagcac tttctgaacc tacagaagtt gggtattgtc tgaaatccca   3060

gaggacccat aagtgccggt gacaagctgt ctgtcagggg agaggctcca gaacctgggt   3120

tcgtccccag tgagaccgga ggatgatccc ccaaggactg cgcagcatca gctcttggtg   3180

ggcctctgcc ttctcttctg tttggccacc tggtgtggat gtcactgtgt gaagataagg   3240

acagaagtgc agagctgcgc tttgtgtgtt gtctatgtcg gctgagctac caaggtggaa   3300

gttttcatgg agaaaagcac ctggctccag ggccagtgtt acagtgttac cctgtaaggt   3360

gttagcctta aaccaccgag cagcgttctc ttgatgccag tgcagagacc agagtcagat   3420

gcccgaggac agtgggtagg aatttcatca acaaatggac ctatggcatc atggctttag   3480

aagctggtac atttactgag ctgatggaca gtggccttct aaaatatgac acttaaattg   3540

taaatatgca ctgtacttaa ggattcttaa gatgtatttt tttgttattt ctcctccagc   3600

tgctatccct tggctaataa aattctagta atttgaaaaa aaaaaaaaag agagaaagtt   3660

aaaaaaaaaa aaaaaaaa                                                 3678


<210>  3403
<211>  974
<212>  PRT
<213>  Homosapiens

<400>  3403

Met Ala Ala Arg Trp Ser Ser Glu Asn Val Val Val Glu Phe Arg Asp 
1               5                   10                  15      


Ser Gln Ala Thr Ala Met Ser Val Asp Cys Leu Gly Gln His Ala Val 
            20                  25                  30          


Leu Ser Gly Arg Arg Phe Leu Tyr Ile Val Asn Leu Asp Ala Pro Phe 
        35                  40                  45              


Glu Gly His Arg Lys Ile Ser Arg Gln Ser Lys Trp Asp Ile Gly Ala 
    50                  55                  60                  


Val Gln Trp Asn Pro His Asp Ser Phe Ala His Tyr Phe Ala Ala Ser 
65                  70                  75                  80  


Ser Asn Gln Arg Val Asp Leu Tyr Lys Trp Lys Asp Gly Ser Gly Glu 
                85                  90                  95      


Val Gly Thr Thr Leu Gln Gly His Thr Arg Val Ile Ser Asp Leu Asp 
            100                 105                 110         


Trp Ala Val Phe Glu Pro Asp Leu Leu Val Thr Ser Ser Val Asp Thr 
        115                 120                 125             


Tyr Ile Tyr Ile Trp Asp Ile Lys Asp Thr Arg Lys Pro Thr Val Ala 
    130                 135                 140                 


Leu Ser Ala Val Ala Gly Ala Ser Gln Val Lys Trp Asn Lys Lys Asn 
145                 150                 155                 160 


Ala Asn Cys Leu Ala Thr Ser His Asp Gly Asp Val Arg Ile Trp Asp 
                165                 170                 175     


Lys Arg Lys Pro Ser Thr Ala Val Glu Tyr Leu Ala Ala His Leu Ser 
            180                 185                 190         


Lys Ile His Gly Leu Asp Trp His Pro Asp Ser Glu His Ile Leu Ala 
        195                 200                 205             


Thr Ser Ser Gln Asp Asn Ser Val Lys Phe Trp Asp Tyr Arg Gln Pro 
    210                 215                 220                 


Arg Lys Tyr Leu Asn Ile Leu Pro Cys Gln Val Pro Val Trp Lys Ala 
225                 230                 235                 240 


Arg Tyr Thr Pro Phe Ser Asn Gly Leu Val Thr Val Met Val Pro Gln 
                245                 250                 255     


Leu Arg Arg Glu Asn Ser Leu Leu Leu Trp Asn Val Phe Asp Leu Asn 
            260                 265                 270         


Thr Pro Val His Thr Phe Val Gly His Asp Asp Val Val Leu Glu Phe 
        275                 280                 285             


Gln Trp Arg Lys Gln Lys Glu Gly Ser Lys Asp Tyr Gln Leu Val Thr 
    290                 295                 300                 


Trp Ser Arg Asp Gln Thr Leu Arg Met Trp Arg Val Asp Ser Gln Met 
305                 310                 315                 320 


Gln Arg Leu Cys Ala Asn Asp Ile Leu Asp Gly Val Asp Glu Phe Ile 
                325                 330                 335     


Glu Ser Ile Ser Leu Leu Pro Glu Pro Glu Lys Thr Leu His Thr Glu 
            340                 345                 350         


Asp Thr Asp His Gln His Thr Ala Ser His Gly Glu Glu Glu Ala Leu 
        355                 360                 365             


Lys Glu Asp Pro Pro Arg Asn Leu Leu Glu Glu Arg Lys Ser Asp Gln 
    370                 375                 380                 


Leu Gly Leu Pro Gln Thr Leu Gln Gln Glu Phe Ser Leu Ile Asn Val 
385                 390                 395                 400 


Gln Ile Arg Asn Val Asn Val Glu Met Asp Ala Ala Asp Arg Ser Cys 
                405                 410                 415     


Thr Val Ser Val His Cys Ser Asn His Arg Val Lys Met Leu Val Lys 
            420                 425                 430         


Phe Pro Ala Gln Tyr Pro Asn Asn Ala Ala Pro Ser Phe Gln Phe Ile 
        435                 440                 445             


Asn Pro Thr Thr Ile Thr Ser Thr Met Lys Ala Lys Leu Leu Lys Ile 
    450                 455                 460                 


Leu Lys Asp Thr Ala Leu Gln Lys Val Lys Arg Gly Gln Ser Cys Leu 
465                 470                 475                 480 


Glu Pro Cys Leu Arg Gln Leu Val Ser Cys Leu Glu Ser Phe Val Asn 
                485                 490                 495     


Gln Glu Asp Ser Ala Ser Ser Asn Pro Phe Ala Leu Pro Asn Ser Val 
            500                 505                 510         


Thr Pro Pro Leu Pro Thr Phe Ala Arg Val Thr Thr Ala Tyr Gly Ser 
        515                 520                 525             


Tyr Gln Asp Ala Asn Ile Pro Phe Pro Arg Thr Ser Gly Ala Arg Phe 
    530                 535                 540                 


Cys Gly Ala Gly Tyr Leu Val Tyr Phe Thr Arg Pro Met Thr Met His 
545                 550                 555                 560 


Arg Ala Val Ser Pro Thr Glu Pro Thr Pro Arg Ser Leu Ser Ala Leu 
                565                 570                 575     


Ser Ala Tyr His Thr Gly Leu Ile Ala Pro Met Lys Ile Arg Thr Glu 
            580                 585                 590         


Ala Pro Gly Asn Leu Arg Leu Tyr Ser Gly Ser Pro Thr Arg Ser Glu 
        595                 600                 605             


Lys Glu Gln Val Ser Ile Ser Ser Phe Tyr Tyr Lys Glu Arg Lys Ser 
    610                 615                 620                 


Arg Arg Trp Lys Ser Lys Arg Glu Gly Ser Asp Ser Gly Asn Arg Gln 
625                 630                 635                 640 


Ile Lys Ala Ala Gly Lys Val Ile Ile Gln Asp Ile Ala Cys Leu Leu 
                645                 650                 655     


Pro Val His Lys Ser Leu Gly Glu Leu Tyr Ile Leu Asn Val Asn Asp 
            660                 665                 670         


Ile Gln Glu Thr Cys Gln Lys Asn Ala Ala Ser Ala Leu Leu Val Gly 
        675                 680                 685             


Arg Lys Asp Leu Val Gln Val Trp Ser Leu Ala Thr Val Ala Thr Asp 
    690                 695                 700                 


Leu Cys Leu Gly Pro Lys Ser Asp Pro Asp Leu Glu Thr Pro Trp Ala 
705                 710                 715                 720 


Arg His Pro Phe Gly Arg Gln Leu Leu Glu Ser Leu Leu Ala His Tyr 
                725                 730                 735     


Cys Arg Leu Arg Asp Val Gln Thr Leu Ala Met Leu Cys Ser Val Phe 
            740                 745                 750         


Glu Ala Gln Ser Arg Pro Gln Gly Leu Pro Asn Pro Phe Gly Pro Phe 
        755                 760                 765             


Pro Asn Arg Ser Ser Asn Leu Val Val Ser His Ser Arg Tyr Pro Ser 
    770                 775                 780                 


Phe Thr Ser Ser Gly Ser Cys Ser Ser Met Ser Asp Pro Gly Leu Asn 
785                 790                 795                 800 


Thr Gly Gly Trp Asn Ile Ala Gly Arg Glu Ala Glu His Leu Ser Ser 
                805                 810                 815     


Pro Trp Gly Glu Ser Ser Pro Glu Glu Leu Arg Phe Gly Ser Leu Thr 
            820                 825                 830         


Tyr Ser Asp Pro Arg Glu Arg Glu Arg Asp Gln His Asp Lys Asn Lys 
        835                 840                 845             


Arg Leu Leu Asp Pro Ala Asn Thr Gln Gln Phe Asp Asp Phe Lys Lys 
    850                 855                 860                 


Cys Tyr Gly Glu Ile Leu Tyr Arg Trp Gly Leu Arg Glu Lys Arg Ala 
865                 870                 875                 880 


Glu Val Leu Lys Phe Val Ser Cys Pro Pro Asp Pro His Lys Gly Ile 
                885                 890                 895     


Glu Phe Gly Val Tyr Cys Ser His Cys Arg Ser Glu Val Arg Gly Thr 
            900                 905                 910         


Gln Cys Ala Ile Cys Lys Gly Phe Thr Phe Gln Cys Ala Ile Cys His 
        915                 920                 925             


Val Ala Val Arg Gly Ser Ser Asn Phe Cys Leu Thr Cys Gly His Gly 
    930                 935                 940                 


Gly His Thr Ser His Met Met Glu Trp Phe Arg Thr Gln Glu Val Cys 
945                 950                 955                 960 


Pro Thr Gly Cys Gly Cys His Cys Leu Leu Glu Ser Thr Phe 
                965                 970                 


<210>  3404
<211>  4633
<212>  DNA
<213>  Homosapiens

<400>  3404
gccctccatt gtctccacgg cggcgaggag cgccggcgag cgcagcccgg gaccgagcgg     60

ggcggcgcgg ctggcggggc cggcggcggc tgaagcgaga gcgcgacgcg acgcgaccgc    120

ggcttcccga gctgcgcctg gccgcccagc gccgcggccc gcccgaggcc tggaggggtc    180

cgggccgccg tccatggtcg cggcgtcctg aggcggggga cgcgcccggc gcccccggcc    240

ctcctccgcc tcctcccgcg gggcgggcgg cctcctccgg cgcctccccg cgcccgcccg    300

ccgctcgccg ccgcctccct ccctccttcc ctgcggctcc cccggctttc ggagcccggg    360

ggcggcctgt ggcgcgcgga gcccgcgccg gactgcgcct ctttggacct tgaggggaaa    420

catgcgtttg ccttggatcg tttgaaattc tgagtttggg atccccgccc gcccgcctgc    480

ctcttccgcc ccgcgggttt tttccttttt tccttttgct ttttttcctt ttctccctcc    540

gggtctcctt tttgactccc tcccccttta tgctcgccca gccctccccc tgctgctgag    600

aagtggggga gggtctcggc ctccaggttc ccgccccacc ggggcccggg cgagcatggg    660

gggcaagcag agcacggcgg cccgctcccg gggccccttc ccgggggtct ccaccgatga    720

cagcgccgtg ccgccgccgg gaggggcgcc ccatttcggg cactaccgga cgggcggcgg    780

ggccatgggg ctgcgcagcc gctcggtcag ctcggtggca ggcatgggca tggaccccag    840

cacggccggg ggggtgccct ttggcctcta cacccccgcc tcccggggca ccggcgactc    900

cgagagggcg cccggcggcg gagggtctgc gtccgactcc acctatgccc atggcaatgg    960

ttaccaggag acgggcggcg gtcaccatag agacgggatg ctgtacctgg gctcccgagc   1020

ctcgctggcg gatgctctac ctctgcacat cgcacccagg tggttcagct cgcatagtgg   1080

tttcaagtgc cccatttgct ccaagtctgt ggcttctgac gagatggaaa tgcactttat   1140

aatgtgtttg agcaaacctc gcctctccta caacgatgat gtgctgacta aagacgcggg   1200

tgagtgtgtg atctgcctgg aggagctgct gcagggggac acgatagcca ggctgccctg   1260

cctgtgcatc tatcacaaaa gctgcataga ctcgtggttt gaagtgaaca gatcttgtcc   1320

ggaacaccct gcggactgac ctgcgggctt gcttgctgac tcctctcaaa gggacagagc   1380

gcccctgctc cagggaggag gctcaccgga ccctggggca gagctgagct tgggacacca   1440

gcgggaacag ggcacccctt ctgcactgac ttccagatca tggttctccc ttcctccctg   1500

aggacaccaa attggatgag agcaagtttg agagaagaat gaatcaactg ctatccttcc   1560

cctcacccct cagcccagga gggaaagggc attttctttt tcatctttga aaggcattgt   1620

gggtctgtct ttaaagtgtt tacaaaaaaa aattatataa aaaaaaagtc tagtgtcgac   1680

tggtgttttc cctcgtgatg tttacagctt gctgtttgct gcccagccat aacccactca   1740

gtgacagacg aacacagcta aggcctcgct gccagccttc tgacggcggg cgagcacacg   1800

gtctcttccc ctgccccaac tggccctctc caccaccaac ttctctactt tgggtttgtt   1860

tggttttttc cctctatttt tctggctggt tttttgctct tttctcccct tgagacccta   1920

atatcttgac ttcattgcca aaaaacaacc cattgagaac tttcttccta ctgatcccat   1980

ctcttttccc ttctttcctc ctggttccgg tcagttcaga ggatttaaca atcacaagtg   2040

tcctgcaaaa atgcctgaac attattctta ggccctcgtg gatttttttt ttcagaaaac   2100

ttaaacaaaa aaagacttac taagaaatat gtacagctac ccctgttttc aggcactatg   2160

tttgagaaca ttttagccat tgatgttcac acgtggcatc agcccatgca agataggttt   2220

ctgtatttat atattaaaat acaaaaaaaa acttataaaa tgtttaaaaa aatgttcaaa   2280

gcttgggaga aaagctttct tcattagtca aggtgttttg atatggtatt aaaatgtcta   2340

ataaaagatg gcactgcgtg attttatttt aatgaagtgt tatacaatca agaaatgggg   2400

gcaagggcct gccccccact ccctcaccta cctccttagc attccttcag gctgctactc   2460

ggggctccag gtgtgtgaat tggtcctcag atagtcaggc ctgggtggag ggagtggcaa   2520

gtcaggcgtg cctcctacaa gcttcctaac ctcttaagca tcatggaacc agtcagccct   2580

ctgtggagtc attgtgccgg acctctgaaa agatctgcag gggccaagat gttgcagcca   2640

ccggaggctg caaggatgtg ggttcttcca ggtgtgggcc cagcccccct ccttccagcc   2700

tttgctcccc atcccacgtt ccactcgccc tgcctgttgt tcagtttgcg tctcagtgct   2760

gactcacggg catgcttcat tgaggcccag gaagaggccc tggtttgggg ctgtgccagc   2820

tcagagccct tgaaccagaa ccaactgctc aggctcacaa aagttggcaa aatgcgggct   2880

gggcaggcag ctcggggcag ggagcagcag tgcaggcctg gcctgtgtcc ccgtgcccag   2940

cgggctcccg gagcagcatt ccagagcctc ctgcagagcc agcgaaggaa agctctagag   3000

ggagacgact ccaccgcctc tctgctctga cccttctcag gcccgcctga tgtgctggac   3060

catccccctg ctgccacggc ccctggctcc gcagtcaccc tccatcagat gcttccagaa   3120

gcacctactc tgtgcaaggg cattcacaac aggccagtgg gcaaacgtga gccagggcca   3180

gcggagaaac actaaagaag actcggtggt tcagagcctg ggtctcagcg cgggacccgt   3240

ctggggtgaa gaccttgggg ctgttgtgag tcggtggcag gaacgtgggc tctagactgt   3300

gcattcaggc tctcctactt ggcagaatga tcttggggaa acgacttcat ctgaacttca   3360

gatatttcac atgtgaagcg gggacaaaac catgcagctc agaggtccct gtgggggctg   3420

ggggagctgc cctgcaggtc ttggcacatg cacagcaggc tccccatagc tttgtcacca   3480

caaagggcac tgttctattc acagcacctc ctgcttctgc ctggcaactg tgtctccctg   3540

tgctatattt aattccacca gcaaagctgg cgaggcaggg cccagccctg aaggagatct   3600

ccttgcctga cccctggacc tggaaatgga ggcttcatgt gcccgccttg gcggcttaag   3660

cctgctgctt tggcagtgcc atgggtgagc cgagcagctg tgaggtgggt ggggcagggc   3720

tgtagcccac gccgggtgct attccaggct ctaggggctg gtgctcatcc ccacccccag   3780

cgacttccgt cctacctggc atgctgcagc cctctgccgg ctgtggtgtc ctctgaattt   3840

ggacccaggt tgcctgctct tgttgtgggg gtgggattgg ggctgtctgt gtttcccagg   3900

tggagctcat gtttgtgatc ctctatctgg acagctctcc agaatcctgt gttgcccctg   3960

ttctgccttt ctgggatggg agagaaggtg agggagccgg cgagcaggtt ctaccctctc   4020

tgctaagggc ctagcacact ttgatgaggt tcctggacgt gagaccctca caaagaccaa   4080

ccattcctct aatagccatt taacggtact gcagttcatg ggaaaatgtc ctcattctta   4140

ggagatagat gctggattat ataggtgaat gccttcaaga aatgtgtaat ttaattccaa   4200

atagttcccc ccaaaataca caaagcaaat aaggccaaaa tgttcattgt tgaatctgca   4260

gtggctggta tttcagtgaa cagtgtactt gttctttcaa cttttctgta tgtttggaat   4320

ttttcttaat aaaagattgt gggaaatggt catttgctga gcgcctccta gttgccaggc   4380

actggagggc gcatcaaaga agagtcctac ccaggaggga gagcgcagct gctgcaggat   4440

tctcgcctgg aagagtgggt ggctggctgg ctggctggaa ggggaggggc gagagggctg   4500

tctcggtgat gagcacacgc gtgctggggt ggtttgggga gagggctgag atttgtcacc   4560

agtgagccct tggcacggtc tctgctcccc accagggcag cacgggacag aaacgtcacg   4620

gaggagtagc ctc                                                      4633


<210>  3405
<211>  227
<212>  PRT
<213>  Homosapiens

<400>  3405

Met Gly Gly Lys Gln Ser Thr Ala Ala Arg Ser Arg Gly Pro Phe Pro 
1               5                   10                  15      


Gly Val Ser Thr Asp Asp Ser Ala Val Pro Pro Pro Gly Gly Ala Pro 
            20                  25                  30          


His Phe Gly His Tyr Arg Thr Gly Gly Gly Ala Met Gly Leu Arg Ser 
        35                  40                  45              


Arg Ser Val Ser Ser Val Ala Gly Met Gly Met Asp Pro Ser Thr Ala 
    50                  55                  60                  


Gly Gly Val Pro Phe Gly Leu Tyr Thr Pro Ala Ser Arg Gly Thr Gly 
65                  70                  75                  80  


Asp Ser Glu Arg Ala Pro Gly Gly Gly Gly Ser Ala Ser Asp Ser Thr 
                85                  90                  95      


Tyr Ala His Gly Asn Gly Tyr Gln Glu Thr Gly Gly Gly His His Arg 
            100                 105                 110         


Asp Gly Met Leu Tyr Leu Gly Ser Arg Ala Ser Leu Ala Asp Ala Leu 
        115                 120                 125             


Pro Leu His Ile Ala Pro Arg Trp Phe Ser Ser His Ser Gly Phe Lys 
    130                 135                 140                 


Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met Glu Met His 
145                 150                 155                 160 


Phe Ile Met Cys Leu Ser Lys Pro Arg Leu Ser Tyr Asn Asp Asp Val 
                165                 170                 175     


Leu Thr Lys Asp Ala Gly Glu Cys Val Ile Cys Leu Glu Glu Leu Leu 
            180                 185                 190         


Gln Gly Asp Thr Ile Ala Arg Leu Pro Cys Leu Cys Ile Tyr His Lys 
        195                 200                 205             


Ser Cys Ile Asp Ser Trp Phe Glu Val Asn Arg Ser Cys Pro Glu His 
    210                 215                 220                 


Pro Ala Asp 
225         


<210>  3406
<211>  2091
<212>  DNA
<213>  Homosapiens

<400>  3406
ggtcaccctg ccacccagtg ctcacaccct ctggccagtg cctggctatg gcccgactgc     60

tcaggtctgc aacctgggag ctgttcccct ggaggggcta ctgctcccag aaggcaaagg    120

gagagctctg cagggacttc gtagaggctc tgaaggccgt ggtgggcggc tcccacgtgt    180

ccactgccgc ggtggtccga gagcagcacg ggcgcgatga gtcggtgcac aggtgcgaac    240

ctcctgatgc tgtggtgtgg ccccagaacg tggagcaggt cagccggctg gcagccctgt    300

gctatcgcca aggtgtgccc atcatcccat tcggcaccgg caccgggctt gagggtggcg    360

tctgtgctgt gcagggcggc gtctgcgtta acctgacgca tatggaccga atcctggagc    420

tgaaccagga ggacttctct gtggtggtgg agccaggtgt cacccgcaaa gccctcaacg    480

cccacctgcg ggacagcggc ctctggtttc ccgtggaccc aggcgcggac gcctctctct    540

gtggcatggc ggccaccggg gcgtcgggga ccaacgcggt ccgctacggc accatgcggg    600

acaacgtgct caacctggag gtggtgctgc ccgacgggcg gctgctgcac acggcgggcc    660

gaggccggca tttccgcttc ggcttctggc cagaaatccc tcatcacaca gcctggtact    720

caccttgtgt gtccctggga cgtaggaaga gtgcagccgg ctacaacctc acggggctct    780

tcgtgggctc cgaggggacg ctgggcctca tcacagccac caccctgcgc ctgcaccctg    840

cccctgaggc cacagtggcc gccacgtgtg cgttccccag tgtccaggct gctgtggaca    900

gcactgtaca catcctccag gctgcagtgc ccgtagcccg cattgagttc ctggatgaag    960

tcatgatgga tgcctgcaac aggtacagca agctgaattg cttagtggcg cccacactct   1020

tcctggagtt ccatggctcc cagcaggcac tggaggagca gctgcagcgc acagaggaga   1080

tagtccagca gaacggagcc tctgacttct cctgggccaa ggaggccgag gagcgcagcc   1140

ggctttggac agcacggcac aatgcctggt acgcagccct ggccacgcgg ccaggctgca   1200

agggctactc cacggatgtg tgtgtgccca tctcccggct gccggagatc gtggtgcaga   1260

ccaaggagga tctgaatgcc tcaggactca caggaagcat tgtcgggcat gtgggtgacg   1320

gcaacttcca ctgcatcctg ctggtcaacc ctgatgacgc cgaggaactg ggcagggtca   1380

aggcttttgc agaacagctg ggcaggcggg cactggctct ccacggaacg tgcacggggg   1440

agcatggcat cggaatgggc aagcggcagc tgctgcagga ggaggtgggc gccgtgggcg   1500

tggagaccat gcggcagctc aaggccgtgc tagaccccca aggcctcatg aatccaggca   1560

aagtgctgtg aagggggtct gagcacttag cccacaagtt ccctgactac ggagccggtt   1620

ctggaacttt tcttcatgcc acggcccctg caaggaaata gatgctgagg cagtcttcct   1680

gccagcgagc ccactgtatc tgggcccaag gccagagggc ccagagagaa gcctgagcac   1740

cgtgttacct ccctggccct ctggctggcc ccaggagcct ttggttcagt aaacgaccca   1800

gggtggttcc cagcaaagct gcttcctctc tgctcctacg catcctgtcc tggcgggaag   1860

agagcgtctg ggtccattca agactctgat gacacccctc cccgaggcct cccactgccg   1920

gggtcccagg acccttcccc cttcacctgg tgacaggaac actcctttcc tggtatggaa   1980

cgtgagctcc cgtgacatga tgataggtct tctccttggg gcctccccca ataaatctgt   2040

aataaacctg aaacccacct acagctaaaa aaaaaaaaaa aaaaaaaaaa a            2091


<210>  3407
<211>  507
<212>  PRT
<213>  Homosapiens

<400>  3407

Met Ala Arg Leu Leu Arg Ser Ala Thr Trp Glu Leu Phe Pro Trp Arg 
1               5                   10                  15      


Gly Tyr Cys Ser Gln Lys Ala Lys Gly Glu Leu Cys Arg Asp Phe Val 
            20                  25                  30          


Glu Ala Leu Lys Ala Val Val Gly Gly Ser His Val Ser Thr Ala Ala 
        35                  40                  45              


Val Val Arg Glu Gln His Gly Arg Asp Glu Ser Val His Arg Cys Glu 
    50                  55                  60                  


Pro Pro Asp Ala Val Val Trp Pro Gln Asn Val Glu Gln Val Ser Arg 
65                  70                  75                  80  


Leu Ala Ala Leu Cys Tyr Arg Gln Gly Val Pro Ile Ile Pro Phe Gly 
                85                  90                  95      


Thr Gly Thr Gly Leu Glu Gly Gly Val Cys Ala Val Gln Gly Gly Val 
            100                 105                 110         


Cys Val Asn Leu Thr His Met Asp Arg Ile Leu Glu Leu Asn Gln Glu 
        115                 120                 125             


Asp Phe Ser Val Val Val Glu Pro Gly Val Thr Arg Lys Ala Leu Asn 
    130                 135                 140                 


Ala His Leu Arg Asp Ser Gly Leu Trp Phe Pro Val Asp Pro Gly Ala 
145                 150                 155                 160 


Asp Ala Ser Leu Cys Gly Met Ala Ala Thr Gly Ala Ser Gly Thr Asn 
                165                 170                 175     


Ala Val Arg Tyr Gly Thr Met Arg Asp Asn Val Leu Asn Leu Glu Val 
            180                 185                 190         


Val Leu Pro Asp Gly Arg Leu Leu His Thr Ala Gly Arg Gly Arg His 
        195                 200                 205             


Phe Arg Phe Gly Phe Trp Pro Glu Ile Pro His His Thr Ala Trp Tyr 
    210                 215                 220                 


Ser Pro Cys Val Ser Leu Gly Arg Arg Lys Ser Ala Ala Gly Tyr Asn 
225                 230                 235                 240 


Leu Thr Gly Leu Phe Val Gly Ser Glu Gly Thr Leu Gly Leu Ile Thr 
                245                 250                 255     


Ala Thr Thr Leu Arg Leu His Pro Ala Pro Glu Ala Thr Val Ala Ala 
            260                 265                 270         


Thr Cys Ala Phe Pro Ser Val Gln Ala Ala Val Asp Ser Thr Val His 
        275                 280                 285             


Ile Leu Gln Ala Ala Val Pro Val Ala Arg Ile Glu Phe Leu Asp Glu 
    290                 295                 300                 


Val Met Met Asp Ala Cys Asn Arg Tyr Ser Lys Leu Asn Cys Leu Val 
305                 310                 315                 320 


Ala Pro Thr Leu Phe Leu Glu Phe His Gly Ser Gln Gln Ala Leu Glu 
                325                 330                 335     


Glu Gln Leu Gln Arg Thr Glu Glu Ile Val Gln Gln Asn Gly Ala Ser 
            340                 345                 350         


Asp Phe Ser Trp Ala Lys Glu Ala Glu Glu Arg Ser Arg Leu Trp Thr 
        355                 360                 365             


Ala Arg His Asn Ala Trp Tyr Ala Ala Leu Ala Thr Arg Pro Gly Cys 
    370                 375                 380                 


Lys Gly Tyr Ser Thr Asp Val Cys Val Pro Ile Ser Arg Leu Pro Glu 
385                 390                 395                 400 


Ile Val Val Gln Thr Lys Glu Asp Leu Asn Ala Ser Gly Leu Thr Gly 
                405                 410                 415     


Ser Ile Val Gly His Val Gly Asp Gly Asn Phe His Cys Ile Leu Leu 
            420                 425                 430         


Val Asn Pro Asp Asp Ala Glu Glu Leu Gly Arg Val Lys Ala Phe Ala 
        435                 440                 445             


Glu Gln Leu Gly Arg Arg Ala Leu Ala Leu His Gly Thr Cys Thr Gly 
    450                 455                 460                 


Glu His Gly Ile Gly Met Gly Lys Arg Gln Leu Leu Gln Glu Glu Val 
465                 470                 475                 480 


Gly Ala Val Gly Val Glu Thr Met Arg Gln Leu Lys Ala Val Leu Asp 
                485                 490                 495     


Pro Gln Gly Leu Met Asn Pro Gly Lys Val Leu 
            500                 505         


<210>  3408
<211>  2022
<212>  DNA
<213>  Homosapiens

<400>  3408
ggtcaccctg ccacccagtg ctcacaccct ctggccagtg cctggctatg gcccgactgc     60

tcaggtctgc aacctgggag ctgttcccct ggaggggcta ctgctcccag aaggcaaagg    120

gagagctctg cagggacttc gtagaggctc tgaaggccgt ggtgggcggc tcccacgtgt    180

ccactgccgc ggtggtccga gagcagcacg ggcgcgatga gtcggtgcac aggtgcgaac    240

ctcctgatgc tgtggtgtgg ccccagaacg tggagcaggt cagccggctg gcagccctgt    300

gctatcgcca aggtgtgccc atcatcccat tcggcaccgg caccgggctt gagggtggcg    360

tctgtgctgt gcagggcggc gtctgcgtta acctgacgca tatggaccga atcctggagc    420

tgaaccagga ggacttctct gtggtggtgg agccaggtgt cacccgcaaa gccctcaacg    480

cccacctgcg ggacagcggc ctctggtttc ccgtggaccc aggcgcggac gcctctctct    540

gtggcatggc ggccaccggg gcgtcgggga ccaacgcggt ccgctacggc accatgcggg    600

acaacgtgct caacctggag gtggtgctgc ccgacgggcg gctgctgcac acggcgggcc    660

gaggccggca tttccggaag agtgcagccg gctacaacct cacggggctc ttcgtgggct    720

ccgaggggac gctgggcctc atcacagcca ccaccctgcg cctgcaccct gcccctgagg    780

ccacagtggc cgccacgtgt gcgttcccca gtgtccaggc tgctgtggac agcactgtac    840

acatcctcca ggctgcagtg cccgtagccc gcattgagtt cctggatgaa gtcatgatgg    900

atgcctgcaa caggtacagc aagctgaatt gcttagtggc gcccacactc ttcctggagt    960

tccatggctc ccagcaggca ctggaggagc agctgcagcg cacagaggag atagtccagc   1020

agaacggagc ctctgacttc tcctgggcca aggaggccga ggagcgcagc cggctttgga   1080

cagcacggca caatgcctgg tacgcagccc tggccacgcg gccaggctgc aagggctact   1140

ccacggatgt gtgtgtgccc atctcccggc tgccggagat cgtggtgcag accaaggagg   1200

atctgaatgc ctcaggactc acaggaagca ttgtcgggca tgtgggtgac ggcaacttcc   1260

actgcatcct gctggtcaac cctgatgacg ccgaggaact gggcagggtc aaggcttttg   1320

cagaacagct gggcaggcgg gcactggctc tccacggaac gtgcacgggg gagcatggca   1380

tcggaatggg caagcggcag ctgctgcagg aggaggtggg cgccgtgggc gtggagacca   1440

tgcggcagct caaggccgtg ctagaccccc aaggcctcat gaatccaggc aaagtgctgt   1500

gaagggggtc tgagcactta gcccacaagt tccctgacta cggagccggt tctggaactt   1560

ttcttcatgc cacggcccct gcaaggaaat agatgctgag gcagtcttcc tgccagcgag   1620

cccactgtat ctgggcccaa ggccagaggg cccagagaga agcctgagca ccgtgttacc   1680

tccctggccc tctggctggc cccaggagcc tttggttcag taaacgaccc agggtggttc   1740

ccagcaaagc tgcttcctct ctgctcctac gcatcctgtc ctggcgggaa gagagcgtct   1800

gggtccattc aagactctga tgacacccct ccccgaggcc tcccactgcc ggggtcccag   1860

gacccttccc ccttcacctg gtgacaggaa cactcctttc ctggtatgga acgtgagctc   1920

ccgtgacatg atgataggtc ttctccttgg ggcctccccc aataaatctg taataaacct   1980

gaaacccacc tacagctaaa aaaaaaaaaa aaaaaaaaaa aa                      2022


<210>  3409
<211>  484
<212>  PRT
<213>  Homosapiens

<400>  3409

Met Ala Arg Leu Leu Arg Ser Ala Thr Trp Glu Leu Phe Pro Trp Arg 
1               5                   10                  15      


Gly Tyr Cys Ser Gln Lys Ala Lys Gly Glu Leu Cys Arg Asp Phe Val 
            20                  25                  30          


Glu Ala Leu Lys Ala Val Val Gly Gly Ser His Val Ser Thr Ala Ala 
        35                  40                  45              


Val Val Arg Glu Gln His Gly Arg Asp Glu Ser Val His Arg Cys Glu 
    50                  55                  60                  


Pro Pro Asp Ala Val Val Trp Pro Gln Asn Val Glu Gln Val Ser Arg 
65                  70                  75                  80  


Leu Ala Ala Leu Cys Tyr Arg Gln Gly Val Pro Ile Ile Pro Phe Gly 
                85                  90                  95      


Thr Gly Thr Gly Leu Glu Gly Gly Val Cys Ala Val Gln Gly Gly Val 
            100                 105                 110         


Cys Val Asn Leu Thr His Met Asp Arg Ile Leu Glu Leu Asn Gln Glu 
        115                 120                 125             


Asp Phe Ser Val Val Val Glu Pro Gly Val Thr Arg Lys Ala Leu Asn 
    130                 135                 140                 


Ala His Leu Arg Asp Ser Gly Leu Trp Phe Pro Val Asp Pro Gly Ala 
145                 150                 155                 160 


Asp Ala Ser Leu Cys Gly Met Ala Ala Thr Gly Ala Ser Gly Thr Asn 
                165                 170                 175     


Ala Val Arg Tyr Gly Thr Met Arg Asp Asn Val Leu Asn Leu Glu Val 
            180                 185                 190         


Val Leu Pro Asp Gly Arg Leu Leu His Thr Ala Gly Arg Gly Arg His 
        195                 200                 205             


Phe Arg Lys Ser Ala Ala Gly Tyr Asn Leu Thr Gly Leu Phe Val Gly 
    210                 215                 220                 


Ser Glu Gly Thr Leu Gly Leu Ile Thr Ala Thr Thr Leu Arg Leu His 
225                 230                 235                 240 


Pro Ala Pro Glu Ala Thr Val Ala Ala Thr Cys Ala Phe Pro Ser Val 
                245                 250                 255     


Gln Ala Ala Val Asp Ser Thr Val His Ile Leu Gln Ala Ala Val Pro 
            260                 265                 270         


Val Ala Arg Ile Glu Phe Leu Asp Glu Val Met Met Asp Ala Cys Asn 
        275                 280                 285             


Arg Tyr Ser Lys Leu Asn Cys Leu Val Ala Pro Thr Leu Phe Leu Glu 
    290                 295                 300                 


Phe His Gly Ser Gln Gln Ala Leu Glu Glu Gln Leu Gln Arg Thr Glu 
305                 310                 315                 320 


Glu Ile Val Gln Gln Asn Gly Ala Ser Asp Phe Ser Trp Ala Lys Glu 
                325                 330                 335     


Ala Glu Glu Arg Ser Arg Leu Trp Thr Ala Arg His Asn Ala Trp Tyr 
            340                 345                 350         


Ala Ala Leu Ala Thr Arg Pro Gly Cys Lys Gly Tyr Ser Thr Asp Val 
        355                 360                 365             


Cys Val Pro Ile Ser Arg Leu Pro Glu Ile Val Val Gln Thr Lys Glu 
    370                 375                 380                 


Asp Leu Asn Ala Ser Gly Leu Thr Gly Ser Ile Val Gly His Val Gly 
385                 390                 395                 400 


Asp Gly Asn Phe His Cys Ile Leu Leu Val Asn Pro Asp Asp Ala Glu 
                405                 410                 415     


Glu Leu Gly Arg Val Lys Ala Phe Ala Glu Gln Leu Gly Arg Arg Ala 
            420                 425                 430         


Leu Ala Leu His Gly Thr Cys Thr Gly Glu His Gly Ile Gly Met Gly 
        435                 440                 445             


Lys Arg Gln Leu Leu Gln Glu Glu Val Gly Ala Val Gly Val Glu Thr 
    450                 455                 460                 


Met Arg Gln Leu Lys Ala Val Leu Asp Pro Gln Gly Leu Met Asn Pro 
465                 470                 475                 480 


Gly Lys Val Leu 
                


<210>  3410
<211>  3190
<212>  DNA
<213>  Homosapiens

<400>  3410
aaaaaacttc ccccaccacc agcggcgagt gggtgacaga gcccccgtct ccgcgcgtct     60

tcgccgccct gcgccgtgac ccgctgtggc actgggccac gagtggaggc tgcgcccctc    120

cagttctgcc ttcatagttc tctgcctttg cccaaaactg cagaaaatga acaaatccca    180

gggatcagtt tcattcacgg atgtgactgt ggactttacc caggaggaat gggaacaact    240

ggacccctct cagaggatcc tatacatgga tgtgatgctg gagaattata gcaacttgct    300

ttcagtgggt aaggacggtt ttcagaagtg tggaaggctg atgaccagat ggagagagac    360

cacagaaacc cagacgagca ggcgaggcaa tttttaattc ttaagaacca aaccccaatt    420

gaggaaagag gcgatctctt tggaaaagca cttaatctga acacagactt tgtttcttta    480

agacaagtac cttataaata tgacttatat gaaaaaactt tgaaatataa ttcagacttg    540

cttaatagta atagaagcta tgcaggaaag cagactgatg agtgtaatga atttggaaaa    600

gcacttctct acctgaagca agagaaaacc cacagtggag tagaatattc tgaatacaat    660

aaaagtggaa aagccctcag ccataaagca gccattttta aacatcagaa aataaaaaac    720

ttggttcaac ctttcatttg tacttactgt gacaaggctt tctcctttaa gtcactcctc    780

attagtcata agagaataca tactggagaa aagccatatg aatgcaatgt atgtaagaaa    840

accttctccc ataaggccaa cctcatcaaa catcagagaa ttcacactgg ggagaaacct    900

ttcgagtgtc cggaatgtgg aaaagctttc acccaccagt caaacctcat tgtacaccag    960

agagcacata tggagaagaa gccctatgag tgcagtgaat gtggaaagac atttgcccaa   1020

aagtttgaac tcaccacaca ccagagaatt catacaggag agcgacccta tgagtgtaac   1080

gaatgtgcaa aaaccttctt taagaagtca aaccttatca tacatcagaa gattcacacg   1140

ggggagaaac gctatgagtg cagtgaatgt ggaaaatcct ttatccagaa ctcacagctc   1200

atcatacaca tgagaactca tacaggagag aaaccctatg aatgtactga gtgcggcaaa   1260

actttcagcc agaggtcaac tcttagatta cacttgcgaa tccacacagg agagaaacca   1320

tatgagtgtt ccgaatgtgg gaaggccttt agcaggaagt cccgactcag tgtccatcag   1380

agagttcaca tcggggagaa accctgaaac tccagccagg tcttactgtg gaaaactcct   1440

gccagaactc ttcaagcggg tgaaaaacct catgacagta ttgagggaac atgggaattt   1500

atactgagat gcaatctctc aactcaaaaa tgtattaaaa ataggatccc atgagaacat   1560

tatactggaa gttacatgtg atacccagct aaagaataca tatcagaata tatccagttg   1620

taaatagcca tacccagttg tactacaatg agctttttaa aatcttgaat gaattgagta   1680

ttctagacag cagcataaga aatatacaaa cagtatccta tgaatttagt ggttttatgt   1740

ggatatgcca caaaacacaa gtggtatgct ttagatctgc acatgtgaat ttagcataat   1800

cactgggaat ttgaaattct tgtcctctgt gataattagg acataacaag attttccata   1860

ctaaacatca catgtgtttt tcagtatctc tgcaatccag tatgcattcc aaatgaaatg   1920

tgtaacattt aaagtagcat ggaacctacg tctttcccta ctgcttgctg gcatatatca   1980

gttggtatga acattgttct tgagctgcct cttaggaaac agaagacagt gttgaagttt   2040

tccctgcttc tggtttgctg aagattttct agactgcttc tggtttgctg aagattttct   2100

agaagcacta tttacacaaa tatgcaaatg tgaaataacc gatctataac gtgaaggagg   2160

cagacatgag ctgtactact cagtatgcac cacagaataa gagtttgccg tgtaaagaca   2220

atatccccat tcgtcatgct cttattttcc cgtgggatat ttgcatacaa atgcatgtct   2280

gttaccaaaa tattgtgtaa cacagacaga aaccacctgt ttttgtcttt ccttgtttcc   2340

cttaatattt catgaattgt ctagcaaaaa tggtaggatg cttctgtagt tcacaaatgt   2400

tacatttcag agactttgga ggaaaaatta ttttaaataa ctgtcaactg tttcattgct   2460

ttttaaattt ttcacgtgca taaccccctt tagaagtaaa tttttacact attttgttgt   2520

ttaaaggagg catttctact tccttgagtt ttgctgttgc caacctaaaa catttccctt   2580

tggaacatga gttataagtt attacttttc ctttacatgt ttacactttt ataaaaatca   2640

gatttttcag tggtctctcc agatattaac aagaattgtt gtgtaactca aagatttgct   2700

tttatagact tgatttcaaa ttcttaagtt cagcctttcc ctatcaatca caaatcatgt   2760

attggaaatt ataaatggca accaaaaacc ggcttttaaa aaatattttt ggatatcatt   2820

gatgtgctgt cacactatat attgagtgac tttctgaaca aatttatcca gaacatccat   2880

agcccaataa gcttttgtct aagttgtcat cttacttact cacaaaggag gggaaaacgt   2940

tattttcata gctgctttta gaaatgtaga ttgtaacagc ctccttggac aacattgtga   3000

gtctgtttta acattaatat actcttacaa cctaggaatc tcctgggaat ctatccctaa   3060

ggagtaaaaa gcgccagcac ttaagattat atgtttacta atgtatattg tattttttgg   3120

taaggaccaa aaaaacaaac aaaaaaaaga ccatcagtaa gggaatggat gaataaattg   3180

tggtaaaaac                                                          3190


<210>  3411
<211>  352
<212>  PRT
<213>  Homosapiens

<400>  3411

Met Glu Arg Asp His Arg Asn Pro Asp Glu Gln Ala Arg Gln Phe Leu 
1               5                   10                  15      


Ile Leu Lys Asn Gln Thr Pro Ile Glu Glu Arg Gly Asp Leu Phe Gly 
            20                  25                  30          


Lys Ala Leu Asn Leu Asn Thr Asp Phe Val Ser Leu Arg Gln Val Pro 
        35                  40                  45              


Tyr Lys Tyr Asp Leu Tyr Glu Lys Thr Leu Lys Tyr Asn Ser Asp Leu 
    50                  55                  60                  


Leu Asn Ser Asn Arg Ser Tyr Ala Gly Lys Gln Thr Asp Glu Cys Asn 
65                  70                  75                  80  


Glu Phe Gly Lys Ala Leu Leu Tyr Leu Lys Gln Glu Lys Thr His Ser 
                85                  90                  95      


Gly Val Glu Tyr Ser Glu Tyr Asn Lys Ser Gly Lys Ala Leu Ser His 
            100                 105                 110         


Lys Ala Ala Ile Phe Lys His Gln Lys Ile Lys Asn Leu Val Gln Pro 
        115                 120                 125             


Phe Ile Cys Thr Tyr Cys Asp Lys Ala Phe Ser Phe Lys Ser Leu Leu 
    130                 135                 140                 


Ile Ser His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn 
145                 150                 155                 160 


Val Cys Lys Lys Thr Phe Ser His Lys Ala Asn Leu Ile Lys His Gln 
                165                 170                 175     


Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Pro Glu Cys Gly Lys 
            180                 185                 190         


Ala Phe Thr His Gln Ser Asn Leu Ile Val His Gln Arg Ala His Met 
        195                 200                 205             


Glu Lys Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Thr Phe Ala Gln 
    210                 215                 220                 


Lys Phe Glu Leu Thr Thr His Gln Arg Ile His Thr Gly Glu Arg Pro 
225                 230                 235                 240 


Tyr Glu Cys Asn Glu Cys Ala Lys Thr Phe Phe Lys Lys Ser Asn Leu 
                245                 250                 255     


Ile Ile His Gln Lys Ile His Thr Gly Glu Lys Arg Tyr Glu Cys Ser 
            260                 265                 270         


Glu Cys Gly Lys Ser Phe Ile Gln Asn Ser Gln Leu Ile Ile His Met 
        275                 280                 285             


Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys 
    290                 295                 300                 


Thr Phe Ser Gln Arg Ser Thr Leu Arg Leu His Leu Arg Ile His Thr 
305                 310                 315                 320 


Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser Arg 
                325                 330                 335     


Lys Ser Arg Leu Ser Val His Gln Arg Val His Ile Gly Glu Lys Pro 
            340                 345                 350         


<210>  3412
<211>  960
<212>  DNA
<213>  Homosapiens

<400>  3412
ggcagcggca tggcttccct ctggctcctc tcctgcttct cccttgtggg ggccgccttt     60

ggctgcgggg tccccgccat ccaccctgtg ctcagcggcc tgtccaggat cgtgaatggg    120

gaggacgccg tccccggctc ctggccctgg caggtgtccc tgcaggacaa aaccggcttc    180

cacttctgcg ggggctccct catcagcgag gactgggtgg tcaccgctgc ccactgcggg    240

gtcaggacct ccgacgtggt cgtggctggg gagtttgacc agggctctga cgaggagaac    300

atccaggtcc tgaagatcgc caaggtcttc aagaacccca agttcagcat tctgaccgtg    360

aacaatgaca tcaccctgct gaagctggcc acacctgccc gcttctccca gacagtgtcc    420

gccgtgtgcc tgcccagcgc cgacgacgac ttccccgcgg ggacactgtg tgccaccaca    480

ggctggggca agaccaagta caacgccaac aagacccctg acaagctgca gcaggcagcc    540

ctgcccctcc tgtccaatgc cgaatgcaag aagtcctggg gcaggaggat caccgacgtg    600

atgatctgtg ccggggccag tggcgtctcc tcctgcatgg gtgactctgg aggccccctg    660

gtctgccaga aggacggagc ctggaccctg gtgggcattg tgtcctgggg cagccgcacc    720

tgctctacca ccacgcccgc tgtgtacgcc cgtgtcacca agctcatacc ctgggtgcag    780

aagatcctgg ccgccaactg agcccgcagc tcctgccacc cctgccttaa gatttcccat    840

taaatgcatc tgtttagaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    960


<210>  3413
<211>  263
<212>  PRT
<213>  Homosapiens

<400>  3413

Met Ala Ser Leu Trp Leu Leu Ser Cys Phe Ser Leu Val Gly Ala Ala 
1               5                   10                  15      


Phe Gly Cys Gly Val Pro Ala Ile His Pro Val Leu Ser Gly Leu Ser 
            20                  25                  30          


Arg Ile Val Asn Gly Glu Asp Ala Val Pro Gly Ser Trp Pro Trp Gln 
        35                  40                  45              


Val Ser Leu Gln Asp Lys Thr Gly Phe His Phe Cys Gly Gly Ser Leu 
    50                  55                  60                  


Ile Ser Glu Asp Trp Val Val Thr Ala Ala His Cys Gly Val Arg Thr 
65                  70                  75                  80  


Ser Asp Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Glu 
                85                  90                  95      


Asn Ile Gln Val Leu Lys Ile Ala Lys Val Phe Lys Asn Pro Lys Phe 
            100                 105                 110         


Ser Ile Leu Thr Val Asn Asn Asp Ile Thr Leu Leu Lys Leu Ala Thr 
        115                 120                 125             


Pro Ala Arg Phe Ser Gln Thr Val Ser Ala Val Cys Leu Pro Ser Ala 
    130                 135                 140                 


Asp Asp Asp Phe Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp Gly 
145                 150                 155                 160 


Lys Thr Lys Tyr Asn Ala Asn Lys Thr Pro Asp Lys Leu Gln Gln Ala 
                165                 170                 175     


Ala Leu Pro Leu Leu Ser Asn Ala Glu Cys Lys Lys Ser Trp Gly Arg 
            180                 185                 190         


Arg Ile Thr Asp Val Met Ile Cys Ala Gly Ala Ser Gly Val Ser Ser 
        195                 200                 205             


Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Asp Gly Ala 
    210                 215                 220                 


Trp Thr Leu Val Gly Ile Val Ser Trp Gly Ser Arg Thr Cys Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Val Tyr Ala Arg Val Thr Lys Leu Ile Pro Trp Val 
                245                 250                 255     


Gln Lys Ile Leu Ala Ala Asn 
            260             


<210>  3414
<211>  915
<212>  DNA
<213>  Homosapiens

<400>  3414
gggaccggca gacaggcgtc ctacacccct gccagcggca ccatggcttt cctctggctc     60

ctctcctgct gggccctcct gggtaccacc ttcggctgcg gggtccccgc catccaccct    120

gtgctcagcg gcctgtccag gatcgtgaat ggggaggacg ccgtccccgg ctcctggccc    180

tggcaggtgt ccctgcagga caaaaccggc ttccacttct gcgggggctc cctcatcagc    240

gaggactggg tggtcaccgc tgcccactgc ggggtcagga cctccgacgt ggtcgtggct    300

ggggagtttg accagggctc tgacgaggag aacatccagg tcctgaagat cgccaaggtc    360

ttcaagaacc ccaagttcag cattctgacc gtgaacaatg acatcaccct gctgaagctg    420

gccacacctg cccgcttctc ccagacagtg tccgccgtgt gcctgcccag cgccgacgac    480

gacttccccg cggggacact gtgtgccacc acaggctggg gcaagaccaa gtacaacgcc    540

aacaagaccc ctgacaagct gcagcaggca gccctgcccc tcctgtccaa tgccgaatgc    600

aagaagtcct ggggcaggag gatcaccgac gtgatgatct gtgccggggc cagtggcgtc    660

tcctcctgca tgggcgactc tggcggtccc ctggtctgcc aaaaggatgg agcctggacc    720

ctggtgggca ttgtgtcctg gggcagcgac acctgctcca cctccagccc tggcgtgtac    780

gcccgtgtca ccaagctcat accttgggtg cagaagatcc tggctgccaa ctgagcccgc    840

ggctccctcc gaccctgctc cccacagagc ctcagtaaac ccatgaaaaa aaaaaaaaaa    900

aaaaaaaaaa aaaaa                                                     915


<210>  3415
<211>  263
<212>  PRT
<213>  Homosapiens

<400>  3415

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Cys Gly Val Pro Ala Ile His Pro Val Leu Ser Gly Leu Ser 
            20                  25                  30          


Arg Ile Val Asn Gly Glu Asp Ala Val Pro Gly Ser Trp Pro Trp Gln 
        35                  40                  45              


Val Ser Leu Gln Asp Lys Thr Gly Phe His Phe Cys Gly Gly Ser Leu 
    50                  55                  60                  


Ile Ser Glu Asp Trp Val Val Thr Ala Ala His Cys Gly Val Arg Thr 
65                  70                  75                  80  


Ser Asp Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Glu 
                85                  90                  95      


Asn Ile Gln Val Leu Lys Ile Ala Lys Val Phe Lys Asn Pro Lys Phe 
            100                 105                 110         


Ser Ile Leu Thr Val Asn Asn Asp Ile Thr Leu Leu Lys Leu Ala Thr 
        115                 120                 125             


Pro Ala Arg Phe Ser Gln Thr Val Ser Ala Val Cys Leu Pro Ser Ala 
    130                 135                 140                 


Asp Asp Asp Phe Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp Gly 
145                 150                 155                 160 


Lys Thr Lys Tyr Asn Ala Asn Lys Thr Pro Asp Lys Leu Gln Gln Ala 
                165                 170                 175     


Ala Leu Pro Leu Leu Ser Asn Ala Glu Cys Lys Lys Ser Trp Gly Arg 
            180                 185                 190         


Arg Ile Thr Asp Val Met Ile Cys Ala Gly Ala Ser Gly Val Ser Ser 
        195                 200                 205             


Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Asp Gly Ala 
    210                 215                 220                 


Trp Thr Leu Val Gly Ile Val Ser Trp Gly Ser Asp Thr Cys Ser Thr 
225                 230                 235                 240 


Ser Ser Pro Gly Val Tyr Ala Arg Val Thr Lys Leu Ile Pro Trp Val 
                245                 250                 255     


Gln Lys Ile Leu Ala Ala Asn 
            260             


<210>  3416
<211>  4455
<212>  DNA
<213>  Homosapiens

<400>  3416
tatataattt tatgattttt aaagtatttt catattctcc tgtctttaag ttttttcttt     60

tctcattgaa cttactagac ttctagtaag ccctggaagt agtaggcata tttttagaga    120

tcttagatcc tagtttttga tgttgttgtt ttacttgttg gttgttttgt ctattgattc    180

cacgaaagcc tcagcactaa ctaaccctaa cgtggcattg ttcctcctgg cagatgactg    240

tgatgatcct cttgtgtctg ccttgcctca ggcatccttc agcagttctt ccgagctctc    300

cagcagtcat ggtcctggat ttgcaaggct gaatagaaga gatggagctg gtggctggtc    360

tccacttgtg tctaacaaat accagtggtt gcagattgac cttggagaga gaatggaggt    420

caccgctgtg gccactcaag ggggatatgg tagctccaac tgggtgacca gctacctcct    480

gatgttcagt gatagtggct ggaactggaa acaatatcgc caagaggaca gcatctgggg    540

tttttcagga aatgcaaatg cagacagtgt tgtgtactat agactccagc cttctatcaa    600

agccagattt ctgcgcttca tccctttgga atggaacccc aagggcagaa ttggaatgcg    660

aatcgaagtg ttcggatgtg catacagatc agaagtggtt gatcttgatg gaaaaagttc    720

ccttctctac agatttgatc aaaaatccct gagcccaata aaagacatta tttctttgaa    780

attcaaaacc atgcagagtg atgggattct actccacagg gaagggccaa atggagatca    840

catcacactg caattaagaa gagcaagact ctttttactt attaattcag gtgaagctaa    900

actgccttcc acttccaccc tggtcaatct caccctgggc agcctgctag atgatcagca    960

ttggcattca gtgctcatcc agcgtttggg caaacaagtc aacttcacag tggacgaaca   1020

caggcatcat ttccatgcac ggggagaatt caatctcatg aatcttgatt atgagatcag   1080

ctttggaggg attccagcac ctggaaaatc agtgtcattc ccacatagaa attttcatgg   1140

atgtttagaa aatctctatt ataatggagt ggatatcatt gatttggcca agcagcaaaa   1200

accacagatc attgctatgg gaaatgtgtc attttcttgt tcacaaccac aatctatgcc   1260

cgtgactttt ctgagctcca ggagttattt agcactgcca gacttctctg gagaggagga   1320

ggtttctgcc acttttcaat ttcgaacttg gaataaggca gggcttctgc tgttcagtga   1380

acttcagctg atttcagggg gtatcctcct ctttctgagt gatggaaaac ttaagtcgaa   1440

tctctaccag ccaggaaaat tacccagtga catcacagca ggtgtcgaat taaatgatgg   1500

gcagtggcat tctgtctctt tatctgctaa aaagaatcac ttgagtgtgg cggtggacgg   1560

ccagatggct tctgctgctc ctctgctggg gcctgagcag atttattcgg gtggcaccta   1620

ttattttgga ggttgtcctg acaaaagctt tggatccaaa tgtaaaagtc cacttggtgg   1680

atttcaggga tgtatgaggc tcatttctat cagcggcaaa gtggtagatc tgatttcagt   1740

tcagcagggg tcccttggga acttcagtga ccttcagata gactcatgtg gcatctcaga   1800

caggtgtttg cccaactatt gtgaacacgg tggggagtgt tcccagtcct ggagcacctt   1860

tcattgtaac tgtaccaaca ctggttacag aggagctact tgccataact ctatctatga   1920

gcagtcatgt gaagcctata agcacagagg aaatacttca gggttttact atatagattc   1980

agatggaagt ggtcccctgg aaccatttct tctatattgc aatatgaccg aaactgcatg   2040

gaccatcata cagcacaacg gctctgactt aacaagagtc agaaatacta atccagagaa   2100

cccatatgct gggtttttcg agtatgtggc cagcatggag caacttcagg ccactattaa   2160

ccgtgcagag cactgtgaac aggagtttac ttattactgc aagaagtcac ggctggtcaa   2220

taagcaagat ggaacccctc tgagttggtg ggtaggaaga accaatgaaa cgcaaaccta   2280

ctggggaggt tcttcgcctg atcttcaaaa atgtacttgt ggattagagg gaaactgcat   2340

tgattctcag tattactgca attgtgatgc tgaccggaat gaatggacca atgacactgg   2400

attgcttgct tataaagaac atcttccagt aactaagatc gtgattacag acacaggccg   2460

actgcattca gaagcagctt ataaactggg gcctctgctc tgccggggag acagatcatt   2520

ttggaattca gcttcctttg ataccgaggc ttcatatctt cattttccta ccttccacgg   2580

agaacttagc gcggatgtat ctttcttttt taagacaaca gcttcatctg gggtattttt   2640

agagaacttg gggattgctg attttatacg gatagagctt cgctctccga cagtagtgac   2700

tttttcattt gatgtgggga atgggccttt tgaaatctca gtgcagtcac ccacccactt   2760

caacgacaac cagtggcacc atgtgagggt tgaaaggaac atgaaggagg cctcccttca   2820

agtggatcag ctgacaccaa agacacagcc cgcccccgct gatgggcatg tcctgttaca   2880

gctcaacagt cagctcttcg tgggtggaac ggccaccaga cagagaggct ttctgggctg   2940

cattcggtct ctgcagttga atgggatgac cctggatttg gaagaaagag cccaggtgac   3000

tccagaagtg cagccaggtt gtaggggaca ttgcagcagc tatgggaagt tatgccgcaa   3060

tggagggaaa tgcagagaaa gacccattgg gttcttttgt gactgcactt tctctgcata   3120

cacagggcca ttctgctcaa atgagatttc tgcatatttt ggatctggct catccgtgat   3180

atacaatttt caagaaaatt atcttttaag taaaaactcc agctcccacg ctgcttcatt   3240

tcatggtgat atgaagctga gcagagaaat gatcaaattt agtttccgaa caacacgaac   3300

accaagcttg ctgctttttg tgagctcctt ttacaaagaa tacctttctg tgatcattgc   3360

caaaaatgga agtttgcaga tcaggtacaa gttaaataaa tatcaagagc ctgatgttgt   3420

taactttgat tttaaaaaca tggctgatgg acaacttcac cacataatga ttaacagaga   3480

agaaggagtg gtctttatag agattgacga taatagaagg agacaagttc acctgtcatc   3540

aggcacagaa ttcagtgcag tcaaatctct ggtattgggc aggattttag aacacagtga   3600

tgtggaccag gagactgcac tggcaggtgc gcagggcttc acaggctgcc tctctgcagt   3660

gcagctcagc cacgtggccc ctctgaaggc agctctgcac cccagccacc cagaccctgt   3720

cactgttaca ggacacgtga ccgagtccag ctgtatggcc cagcctggca ctgatgccac   3780

atcaagggaa aggacacact cgtttgcaga tcattctgga acaatagatg acagagagcc   3840

ccttgctaat gcaatcaaaa gtgactctgc agtaattgga ggtctgatag ctgttgtgat   3900

ttttatcttg ctttgcatca ctgccatagc tgttcgcatt tatcagcaga aaaggttata   3960

taaaagaagt gaggcaaaaa ggtcagagaa tgtagacagt gctgaggctg ttctgaaaag   4020

tgagcttaat atacaaaatg cagtcaatga aaatcagaaa gagtacttct tctgattggc   4080

agctatgatt taacataaaa ttatgatagt ttgttttaat agccaggggt tctcaatgga   4140

aaaacgaatg ctcttacact gaatgtacag gcagtgggct tgcagcactg ccatcttgcc   4200

atgtacaggc ttggggtggc tccaggaagc ctcgtccagt gatatatttc tcatagcatt   4260

cattctatgg aacaagaaat tagatattgc tgttaatttt caactgttct ggtatgatct   4320

aaaacaagtt taacctgctt aatggctaca gtttttacat gtgaaaactg tagccttggt   4380

ctcttaacca tgtaatacat aagttttgtt agaggtaaaa attaaatttg gactataatg   4440

tccttgcttt atttg                                                    4455


<210>  3417
<211>  1311
<212>  PRT
<213>  Homosapiens

<400>  3417

Met Leu Leu Phe Tyr Leu Leu Val Val Leu Ser Ile Asp Ser Thr Lys 
1               5                   10                  15      


Ala Ser Ala Leu Thr Asn Pro Asn Val Ala Leu Phe Leu Leu Ala Asp 
            20                  25                  30          


Asp Cys Asp Asp Pro Leu Val Ser Ala Leu Pro Gln Ala Ser Phe Ser 
        35                  40                  45              


Ser Ser Ser Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ala Arg Leu 
    50                  55                  60                  


Asn Arg Arg Asp Gly Ala Gly Gly Trp Ser Pro Leu Val Ser Asn Lys 
65                  70                  75                  80  


Tyr Gln Trp Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala 
                85                  90                  95      


Val Ala Thr Gln Gly Gly Tyr Gly Ser Ser Asn Trp Val Thr Ser Tyr 
            100                 105                 110         


Leu Leu Met Phe Ser Asp Ser Gly Trp Asn Trp Lys Gln Tyr Arg Gln 
        115                 120                 125             


Glu Asp Ser Ile Trp Gly Phe Ser Gly Asn Ala Asn Ala Asp Ser Val 
    130                 135                 140                 


Val Tyr Tyr Arg Leu Gln Pro Ser Ile Lys Ala Arg Phe Leu Arg Phe 
145                 150                 155                 160 


Ile Pro Leu Glu Trp Asn Pro Lys Gly Arg Ile Gly Met Arg Ile Glu 
                165                 170                 175     


Val Phe Gly Cys Ala Tyr Arg Ser Glu Val Val Asp Leu Asp Gly Lys 
            180                 185                 190         


Ser Ser Leu Leu Tyr Arg Phe Asp Gln Lys Ser Leu Ser Pro Ile Lys 
        195                 200                 205             


Asp Ile Ile Ser Leu Lys Phe Lys Thr Met Gln Ser Asp Gly Ile Leu 
    210                 215                 220                 


Leu His Arg Glu Gly Pro Asn Gly Asp His Ile Thr Leu Gln Leu Arg 
225                 230                 235                 240 


Arg Ala Arg Leu Phe Leu Leu Ile Asn Ser Gly Glu Ala Lys Leu Pro 
                245                 250                 255     


Ser Thr Ser Thr Leu Val Asn Leu Thr Leu Gly Ser Leu Leu Asp Asp 
            260                 265                 270         


Gln His Trp His Ser Val Leu Ile Gln Arg Leu Gly Lys Gln Val Asn 
        275                 280                 285             


Phe Thr Val Asp Glu His Arg His His Phe His Ala Arg Gly Glu Phe 
    290                 295                 300                 


Asn Leu Met Asn Leu Asp Tyr Glu Ile Ser Phe Gly Gly Ile Pro Ala 
305                 310                 315                 320 


Pro Gly Lys Ser Val Ser Phe Pro His Arg Asn Phe His Gly Cys Leu 
                325                 330                 335     


Glu Asn Leu Tyr Tyr Asn Gly Val Asp Ile Ile Asp Leu Ala Lys Gln 
            340                 345                 350         


Gln Lys Pro Gln Ile Ile Ala Met Gly Asn Val Ser Phe Ser Cys Ser 
        355                 360                 365             


Gln Pro Gln Ser Met Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu 
    370                 375                 380                 


Ala Leu Pro Asp Phe Ser Gly Glu Glu Glu Val Ser Ala Thr Phe Gln 
385                 390                 395                 400 


Phe Arg Thr Trp Asn Lys Ala Gly Leu Leu Leu Phe Ser Glu Leu Gln 
                405                 410                 415     


Leu Ile Ser Gly Gly Ile Leu Leu Phe Leu Ser Asp Gly Lys Leu Lys 
            420                 425                 430         


Ser Asn Leu Tyr Gln Pro Gly Lys Leu Pro Ser Asp Ile Thr Ala Gly 
        435                 440                 445             


Val Glu Leu Asn Asp Gly Gln Trp His Ser Val Ser Leu Ser Ala Lys 
    450                 455                 460                 


Lys Asn His Leu Ser Val Ala Val Asp Gly Gln Met Ala Ser Ala Ala 
465                 470                 475                 480 


Pro Leu Leu Gly Pro Glu Gln Ile Tyr Ser Gly Gly Thr Tyr Tyr Phe 
                485                 490                 495     


Gly Gly Cys Pro Asp Lys Ser Phe Gly Ser Lys Cys Lys Ser Pro Leu 
            500                 505                 510         


Gly Gly Phe Gln Gly Cys Met Arg Leu Ile Ser Ile Ser Gly Lys Val 
        515                 520                 525             


Val Asp Leu Ile Ser Val Gln Gln Gly Ser Leu Gly Asn Phe Ser Asp 
    530                 535                 540                 


Leu Gln Ile Asp Ser Cys Gly Ile Ser Asp Arg Cys Leu Pro Asn Tyr 
545                 550                 555                 560 


Cys Glu His Gly Gly Glu Cys Ser Gln Ser Trp Ser Thr Phe His Cys 
                565                 570                 575     


Asn Cys Thr Asn Thr Gly Tyr Arg Gly Ala Thr Cys His Asn Ser Ile 
            580                 585                 590         


Tyr Glu Gln Ser Cys Glu Ala Tyr Lys His Arg Gly Asn Thr Ser Gly 
        595                 600                 605             


Phe Tyr Tyr Ile Asp Ser Asp Gly Ser Gly Pro Leu Glu Pro Phe Leu 
    610                 615                 620                 


Leu Tyr Cys Asn Met Thr Glu Thr Ala Trp Thr Ile Ile Gln His Asn 
625                 630                 635                 640 


Gly Ser Asp Leu Thr Arg Val Arg Asn Thr Asn Pro Glu Asn Pro Tyr 
                645                 650                 655     


Ala Gly Phe Phe Glu Tyr Val Ala Ser Met Glu Gln Leu Gln Ala Thr 
            660                 665                 670         


Ile Asn Arg Ala Glu His Cys Glu Gln Glu Phe Thr Tyr Tyr Cys Lys 
        675                 680                 685             


Lys Ser Arg Leu Val Asn Lys Gln Asp Gly Thr Pro Leu Ser Trp Trp 
    690                 695                 700                 


Val Gly Arg Thr Asn Glu Thr Gln Thr Tyr Trp Gly Gly Ser Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser 
                725                 730                 735     


Gln Tyr Tyr Cys Asn Cys Asp Ala Asp Arg Asn Glu Trp Thr Asn Asp 
            740                 745                 750         


Thr Gly Leu Leu Ala Tyr Lys Glu His Leu Pro Val Thr Lys Ile Val 
        755                 760                 765             


Ile Thr Asp Thr Gly Arg Leu His Ser Glu Ala Ala Tyr Lys Leu Gly 
    770                 775                 780                 


Pro Leu Leu Cys Arg Gly Asp Arg Ser Phe Trp Asn Ser Ala Ser Phe 
785                 790                 795                 800 


Asp Thr Glu Ala Ser Tyr Leu His Phe Pro Thr Phe His Gly Glu Leu 
                805                 810                 815     


Ser Ala Asp Val Ser Phe Phe Phe Lys Thr Thr Ala Ser Ser Gly Val 
            820                 825                 830         


Phe Leu Glu Asn Leu Gly Ile Ala Asp Phe Ile Arg Ile Glu Leu Arg 
        835                 840                 845             


Ser Pro Thr Val Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Phe 
    850                 855                 860                 


Glu Ile Ser Val Gln Ser Pro Thr His Phe Asn Asp Asn Gln Trp His 
865                 870                 875                 880 


His Val Arg Val Glu Arg Asn Met Lys Glu Ala Ser Leu Gln Val Asp 
                885                 890                 895     


Gln Leu Thr Pro Lys Thr Gln Pro Ala Pro Ala Asp Gly His Val Leu 
            900                 905                 910         


Leu Gln Leu Asn Ser Gln Leu Phe Val Gly Gly Thr Ala Thr Arg Gln 
        915                 920                 925             


Arg Gly Phe Leu Gly Cys Ile Arg Ser Leu Gln Leu Asn Gly Met Thr 
    930                 935                 940                 


Leu Asp Leu Glu Glu Arg Ala Gln Val Thr Pro Glu Val Gln Pro Gly 
945                 950                 955                 960 


Cys Arg Gly His Cys Ser Ser Tyr Gly Lys Leu Cys Arg Asn Gly Gly 
                965                 970                 975     


Lys Cys Arg Glu Arg Pro Ile Gly Phe Phe Cys Asp Cys Thr Phe Ser 
            980                 985                 990         


Ala Tyr Thr Gly Pro Phe Cys Ser  Asn Glu Ile Ser Ala  Tyr Phe Gly 
        995                 1000                 1005             


Ser Gly  Ser Ser Val Ile Tyr  Asn Phe Gln Glu Asn  Tyr Leu Leu 
    1010                 1015                 1020             


Ser Lys  Asn Ser Ser Ser His  Ala Ala Ser Phe His  Gly Asp Met 
    1025                 1030                 1035             


Lys Leu  Ser Arg Glu Met Ile  Lys Phe Ser Phe Arg  Thr Thr Arg 
    1040                 1045                 1050             


Thr Pro  Ser Leu Leu Leu Phe  Val Ser Ser Phe Tyr  Lys Glu Tyr 
    1055                 1060                 1065             


Leu Ser  Val Ile Ile Ala Lys  Asn Gly Ser Leu Gln  Ile Arg Tyr 
    1070                 1075                 1080             


Lys Leu  Asn Lys Tyr Gln Glu  Pro Asp Val Val Asn  Phe Asp Phe 
    1085                 1090                 1095             


Lys Asn  Met Ala Asp Gly Gln  Leu His His Ile Met  Ile Asn Arg 
    1100                 1105                 1110             


Glu Glu  Gly Val Val Phe Ile  Glu Ile Asp Asp Asn  Arg Arg Arg 
    1115                 1120                 1125             


Gln Val  His Leu Ser Ser Gly  Thr Glu Phe Ser Ala  Val Lys Ser 
    1130                 1135                 1140             


Leu Val  Leu Gly Arg Ile Leu  Glu His Ser Asp Val  Asp Gln Glu 
    1145                 1150                 1155             


Thr Ala  Leu Ala Gly Ala Gln  Gly Phe Thr Gly Cys  Leu Ser Ala 
    1160                 1165                 1170             


Val Gln  Leu Ser His Val Ala  Pro Leu Lys Ala Ala  Leu His Pro 
    1175                 1180                 1185             


Ser His  Pro Asp Pro Val Thr  Val Thr Gly His Val  Thr Glu Ser 
    1190                 1195                 1200             


Ser Cys  Met Ala Gln Pro Gly  Thr Asp Ala Thr Ser  Arg Glu Arg 
    1205                 1210                 1215             


Thr His  Ser Phe Ala Asp His  Ser Gly Thr Ile Asp  Asp Arg Glu 
    1220                 1225                 1230             


Pro Leu  Ala Asn Ala Ile Lys  Ser Asp Ser Ala Val  Ile Gly Gly 
    1235                 1240                 1245             


Leu Ile  Ala Val Val Ile Phe  Ile Leu Leu Cys Ile  Thr Ala Ile 
    1250                 1255                 1260             


Ala Val  Arg Ile Tyr Gln Gln  Lys Arg Leu Tyr Lys  Arg Ser Glu 
    1265                 1270                 1275             


Ala Lys  Arg Ser Glu Asn Val  Asp Ser Ala Glu Ala  Val Leu Lys 
    1280                 1285                 1290             


Ser Glu  Leu Asn Ile Gln Asn  Ala Val Asn Glu Asn  Gln Lys Glu 
    1295                 1300                 1305             


Tyr Phe  Phe 
    1310     


<210>  3418
<211>  2339
<212>  DNA
<213>  Homosapiens

<400>  3418
ctcattttct cttgcagccg ccatgattct gaggccttcc cagctatgtg gaactatgac     60

tgtgatgatc ctcttgtgtc tgccttgcct caggcatcct tcagcagttc ttccgagctc    120

tccagcagtc atggtcctgg atttgcaagg ctgaatagaa gagatggagc tggtggctgg    180

tctccacttg tgtctaacaa ataccagtgg ttgcagattg accttggaga gagaatggag    240

gtcaccgctg tggccactca agggggatat ggtagctcca actgggtgac cagctacctc    300

ctgatgttca gtgatagtgg ctggaactgg aaacaatatc gccaagagga cagcatctgg    360

ggtttttcag gaaatgcaaa tgcagacagt gttgtgtact atagactcca gccttctatc    420

aaagccagat ttctgcgctt catccctttg gaatggaacc ccaagggcag aattggaatg    480

cgaatcgaag tgttcggatg tgcatacaga tcagaagtgg ttgatcttga tggaaaaagt    540

tcccttctct acagatttga tcaaaaatcc ctgagcccaa taaaagacat tatttctttg    600

aaattcaaaa ccatgcagag tgatgggatt ctactccaca gggaagggcc aaatggagat    660

cacatcacac tgcaattaag aagagcaaga ctctttttac ttattaattc aggtgaagct    720

aaactgcctt ccacttccac cctggtcaat ctcaccctgg gcagcctgct agatgatcag    780

cattggcatt cagtgctcat ccagcgtttg ggcaaacaag tcaacttcac agtggacgaa    840

cacaggcatc atttccatgc acggggagaa ttcaatctca tgaatcttga ttatgagatc    900

agctttggag ggattccagc acctggaaaa tcagtgtcat tcccacatag aaattttcat    960

ggatgtttag aaaatctcta ttataatgga gtggatatca ttgatttggc caagcagcaa   1020

aaaccacaga tcattgctat gggaaatgtg tcattttctt gttcacaacc acaatctatg   1080

cccgtgactt ttctgagctc caggagttat ttagcactgc cagacttctc tggagaggag   1140

gaggtttctg ccacttttca atttcgaact tggaataagg cagggcttct gctgttcagt   1200

gaacttcagc tgatttcagg gggtatcctc ctctttctga gtgatggaaa acttaagtcg   1260

aatctctacc agccaggaaa attacccagt gacatcacag caggtgtcga attaaatgat   1320

gggcagtggc attctgtctc tttatctgct aaaaagaatc acttgagtgt ggcggtggac   1380

ggccagatgg cttctgctgc tcctctgctg gggcctgagc agatttattc gggtggcacc   1440

tattattttg gaggttgtcc tgacaaaagc tttggatcca aatgtaaaag tccacttggt   1500

ggatttcagg gatgtatgag gctcatttct atcagcggca aagtggtaga tctgatttca   1560

gttcagcagg ggtcccttgg gaacttcagt gaccttcaga tagactcatg tggcatctca   1620

gacaggtgtt tgcccaacta ttgtgaacac ggtggggagt gttcccagtc ctggagcacc   1680

tttcattgta actgtaccaa cactggttac agaggagcta cttgccataa ctctatctat   1740

gagcagtcat gtgaagccta taagcacaga ggaaatactt cagggtttta ctatatagat   1800

tcagatggaa gtggtcccct ggaaccattt cttctatatt gcaatatgac cgaaactgca   1860

tggaccatca tacagcacaa cggctctgac ttaacaagag tcagaaatac taatccagag   1920

aacccatatg ctgggttttt cgagtatgtg gccagcatgg agcaacttca ggccactatt   1980

aaccgtgcag agcactgtga acaggagttt acttattact gcaagaagtc acggctggtc   2040

aataagcaag atggaacccc tctgagttgg tgggtaggaa gaaccaatga aacgcaaacc   2100

tactggggag gttcttcgcc tgatcttcaa aaatgtactt gtggattaga gggaaactgc   2160

attgattctc agtattactg caattgtgat gctgaccgga atgaatggtg atttccatac   2220

gatttcttta tgcaagaaaa agttcattta aaaaaattaa tcactcaaag tatgtatagc   2280

tagccagata ctgaacaagt tagtgcaatg aagtaattaa ataaaggttt gttttaatg    2339


<210>  3419
<211>  721
<212>  PRT
<213>  Homosapiens

<400>  3419

Met Trp Asn Tyr Asp Cys Asp Asp Pro Leu Val Ser Ala Leu Pro Gln 
1               5                   10                  15      


Ala Ser Phe Ser Ser Ser Ser Glu Leu Ser Ser Ser His Gly Pro Gly 
            20                  25                  30          


Phe Ala Arg Leu Asn Arg Arg Asp Gly Ala Gly Gly Trp Ser Pro Leu 
        35                  40                  45              


Val Ser Asn Lys Tyr Gln Trp Leu Gln Ile Asp Leu Gly Glu Arg Met 
    50                  55                  60                  


Glu Val Thr Ala Val Ala Thr Gln Gly Gly Tyr Gly Ser Ser Asn Trp 
65                  70                  75                  80  


Val Thr Ser Tyr Leu Leu Met Phe Ser Asp Ser Gly Trp Asn Trp Lys 
                85                  90                  95      


Gln Tyr Arg Gln Glu Asp Ser Ile Trp Gly Phe Ser Gly Asn Ala Asn 
            100                 105                 110         


Ala Asp Ser Val Val Tyr Tyr Arg Leu Gln Pro Ser Ile Lys Ala Arg 
        115                 120                 125             


Phe Leu Arg Phe Ile Pro Leu Glu Trp Asn Pro Lys Gly Arg Ile Gly 
    130                 135                 140                 


Met Arg Ile Glu Val Phe Gly Cys Ala Tyr Arg Ser Glu Val Val Asp 
145                 150                 155                 160 


Leu Asp Gly Lys Ser Ser Leu Leu Tyr Arg Phe Asp Gln Lys Ser Leu 
                165                 170                 175     


Ser Pro Ile Lys Asp Ile Ile Ser Leu Lys Phe Lys Thr Met Gln Ser 
            180                 185                 190         


Asp Gly Ile Leu Leu His Arg Glu Gly Pro Asn Gly Asp His Ile Thr 
        195                 200                 205             


Leu Gln Leu Arg Arg Ala Arg Leu Phe Leu Leu Ile Asn Ser Gly Glu 
    210                 215                 220                 


Ala Lys Leu Pro Ser Thr Ser Thr Leu Val Asn Leu Thr Leu Gly Ser 
225                 230                 235                 240 


Leu Leu Asp Asp Gln His Trp His Ser Val Leu Ile Gln Arg Leu Gly 
                245                 250                 255     


Lys Gln Val Asn Phe Thr Val Asp Glu His Arg His His Phe His Ala 
            260                 265                 270         


Arg Gly Glu Phe Asn Leu Met Asn Leu Asp Tyr Glu Ile Ser Phe Gly 
        275                 280                 285             


Gly Ile Pro Ala Pro Gly Lys Ser Val Ser Phe Pro His Arg Asn Phe 
    290                 295                 300                 


His Gly Cys Leu Glu Asn Leu Tyr Tyr Asn Gly Val Asp Ile Ile Asp 
305                 310                 315                 320 


Leu Ala Lys Gln Gln Lys Pro Gln Ile Ile Ala Met Gly Asn Val Ser 
                325                 330                 335     


Phe Ser Cys Ser Gln Pro Gln Ser Met Pro Val Thr Phe Leu Ser Ser 
            340                 345                 350         


Arg Ser Tyr Leu Ala Leu Pro Asp Phe Ser Gly Glu Glu Glu Val Ser 
        355                 360                 365             


Ala Thr Phe Gln Phe Arg Thr Trp Asn Lys Ala Gly Leu Leu Leu Phe 
    370                 375                 380                 


Ser Glu Leu Gln Leu Ile Ser Gly Gly Ile Leu Leu Phe Leu Ser Asp 
385                 390                 395                 400 


Gly Lys Leu Lys Ser Asn Leu Tyr Gln Pro Gly Lys Leu Pro Ser Asp 
                405                 410                 415     


Ile Thr Ala Gly Val Glu Leu Asn Asp Gly Gln Trp His Ser Val Ser 
            420                 425                 430         


Leu Ser Ala Lys Lys Asn His Leu Ser Val Ala Val Asp Gly Gln Met 
        435                 440                 445             


Ala Ser Ala Ala Pro Leu Leu Gly Pro Glu Gln Ile Tyr Ser Gly Gly 
    450                 455                 460                 


Thr Tyr Tyr Phe Gly Gly Cys Pro Asp Lys Ser Phe Gly Ser Lys Cys 
465                 470                 475                 480 


Lys Ser Pro Leu Gly Gly Phe Gln Gly Cys Met Arg Leu Ile Ser Ile 
                485                 490                 495     


Ser Gly Lys Val Val Asp Leu Ile Ser Val Gln Gln Gly Ser Leu Gly 
            500                 505                 510         


Asn Phe Ser Asp Leu Gln Ile Asp Ser Cys Gly Ile Ser Asp Arg Cys 
        515                 520                 525             


Leu Pro Asn Tyr Cys Glu His Gly Gly Glu Cys Ser Gln Ser Trp Ser 
    530                 535                 540                 


Thr Phe His Cys Asn Cys Thr Asn Thr Gly Tyr Arg Gly Ala Thr Cys 
545                 550                 555                 560 


His Asn Ser Ile Tyr Glu Gln Ser Cys Glu Ala Tyr Lys His Arg Gly 
                565                 570                 575     


Asn Thr Ser Gly Phe Tyr Tyr Ile Asp Ser Asp Gly Ser Gly Pro Leu 
            580                 585                 590         


Glu Pro Phe Leu Leu Tyr Cys Asn Met Thr Glu Thr Ala Trp Thr Ile 
        595                 600                 605             


Ile Gln His Asn Gly Ser Asp Leu Thr Arg Val Arg Asn Thr Asn Pro 
    610                 615                 620                 


Glu Asn Pro Tyr Ala Gly Phe Phe Glu Tyr Val Ala Ser Met Glu Gln 
625                 630                 635                 640 


Leu Gln Ala Thr Ile Asn Arg Ala Glu His Cys Glu Gln Glu Phe Thr 
                645                 650                 655     


Tyr Tyr Cys Lys Lys Ser Arg Leu Val Asn Lys Gln Asp Gly Thr Pro 
            660                 665                 670         


Leu Ser Trp Trp Val Gly Arg Thr Asn Glu Thr Gln Thr Tyr Trp Gly 
        675                 680                 685             


Gly Ser Ser Pro Asp Leu Gln Lys Cys Thr Cys Gly Leu Glu Gly Asn 
    690                 695                 700                 


Cys Ile Asp Ser Gln Tyr Tyr Cys Asn Cys Asp Ala Asp Arg Asn Glu 
705                 710                 715                 720 


Trp 
    


<210>  3420
<211>  3784
<212>  DNA
<213>  Homosapiens

<400>  3420
attcaacagg aggaacccgc gggagaggag ccccactccc ccagcgccgc agccaccgca     60

gccaccgcag cccgtgcgcc ccgcgccctc gagcgccatg gccaaggaag gcgtggagaa    120

ggcggaggag acggagcaaa tgatcgagaa ggaggcaggc aaggagccgg cggagggcgg    180

cggcggcgac ggctcgcacc gcctcgggga cgcccaggag atgcgcgcgg tggtgctggc    240

tggcttcggg gggctcaaca agctgcggct cttcaggaag gccatgcccg agcctcagga    300

cggcgagctc aagatccgcg tcaaagcctg tggattaaac ttcattgact tgatggtgcg    360

acaagggaat attgacaacc ctcccaagac tcccctggtg ccaggatttg agtgttctgg    420

gattgttgaa gctctggggg acagcgtgaa aggatatgag attggagacc gtgtcatggc    480

atttgtcaat tacaatgcct gggcagaggt ggtctgcaca ccagtggagt ttgtctacaa    540

gatcccggat gacatgagct tctcggaggc tgctgcattc cccatgaact tcgtcacagc    600

ctatgtgatg ctgtttgaag ttgccaacct ccgggaaggg atgtctgtgc tcgtgcactc    660

agctggtggg ggcgtgggtc aagctgtggc tcagctgtgt tccactgtcc ccaacgtgac    720

tgtctttgga acagcctcta ctttcaagca tgaagcaatc aaagactctg tgacccacct    780

ctttgacaga aatgcagact acgtgcaaga agttaaaaga atctctgctg aaggtgtgga    840

catcgttttg gattgcctct gtggggacaa cactggaaaa ggtctcagtc ttctcaaacc    900

cctgggaacc tacattttat atggctcatc caacatggta actggagaga ccaagagctt    960

cttcagcttt gcaaaatcat ggtggcaggt ggagaaggtg aaccccatca agctgtatga   1020

ggagaacaaa gtcatcgcgg ggttttccct tttaaatctg ctcttcaaac aaggccgggc   1080

gggcctcatt cggggagtgg tggaaaaact catagggctc tacaaccaga agaagatcaa   1140

gcctgtggtg gactccttgt gggctctgga ggaggtgaag gaggccatgc agcggattca   1200

cgaccgaggg aacattggca agttaattct ggatgtagaa aagaccccaa ctccactgat   1260

ggccaatgac agcacagaga ccagtgaagc aggggaagag gaggaggacc acgagggaga   1320

cagcgagaac aaggagcgga tgccctttat ccagtaactg aggacccagg tgggagaatg   1380

tgaaggatgg tttggaagat gaggacccgg ctgagaaaac tcttctgtgc cccagtgaac   1440

aaatgctgta gtccagtgcg tgtcgtgttt gtctgcagtc agctgagcta aaaagctgtt   1500

gatcactgtt gttttttgaa gtgccaatcc catgccatgc agtattatgt ccctctccta   1560

tctgtgtatt acacattccc ctctcccctg tatcaaaacc atccatctgt gggttcttct   1620

tgacagttct agaacagcct tgcaaattaa tacaagtccc aggcccaatg cctaagagac   1680

cagacgtggg caaagacaag tttggatgga aaggtgttat cacagagccc tgtccagctc   1740

ctagaattcc tcaggccagt gacacttttt tgctgctggc cacccatgcc tctgatgaga   1800

acacttgcca atttggccag cagaaagaga gtaggccgga tgttttcatg agcccacaaa   1860

tttagaaact ctcctagtag tactttttct ctctccattt aagagacaac tacggtcaaa   1920

agtttgagcc attctcttct accccttcag tgtctgaccc tttcactggc tcttatctgt   1980

aaacacaggg aggcaggtat ggatttttca cagtagacaa tgggtcaaca gcatgagttt   2040

gaggacctgc tgtgaagatt tctcctccaa aatacatctc atgggcagga ttcttcctgc   2100

tccatatctg tttcaatttt aagaaagcac cacatacaag acacattcag aagtcattcc   2160

tgagcattgc tggtgtttgc acacttgcca cctgcattac caattctgta aatttcaatt   2220

cctggtggaa agtgaccact ttgaccatgg atttcccaaa gaagagttcc tttgcagacc   2280

ataggtggaa aagtcaatga gcatctcctt ccttgccaaa gcatgtccca acatgtaaca   2340

aactctaggg atacaaaagg tttatattca gcatctgatg tcagatgtac agttcctccc   2400

ctcccatata taaaccccgg tgtagaatct gcagcgccct gctcttcgga aaccaaggaa   2460

caagccacct gctcacacac cttgttcaac ttttcagctc ctaaggaacc ccacccccat   2520

gcaatttgac tgtgcttgag aggtgaatac agttaccttc gagaaacaga gggagctcct   2580

caccccgtcc ttccagtcct tttggctaaa atgcttaact atcactcaca aacaaatgtg   2640

gagataccag gagctcattt gattcatacc ccaactttgt gttctgaaaa acatcagagg   2700

gattttacat tgcccagttt ctccaccaac aagccttagg gtggacccaa ccctttccgc   2760

aagtggtagg aacgaatgca tcttagcaat tacctgattt ccaaagtcct tttgtagcaa   2820

atgtcacctc attcgtggtc tttttaccta tcctaagctt atgatgatga gttatgtatg   2880

ccaaatattt atctgaagag tttctcctca ttgtgaatgt gtatgtaaaa tatgaagaca   2940

agaaagggtg ctttcatctg aggaaccaag gggtgagagt atcccaaagg aggacaccag   3000

catcatcttt tcttcgtact ccaggaccca ccaatattcc agttctgggt catttagaga   3060

gataatgggg cgtttattcc cctattacct ttgctaagtg ctatattatt ggctgtttct   3120

cccgtaacca tgctgaaaag ggggtcttag ggagaactgt catccaagtg gcattcctag   3180

taagttgggt agaaatgaca ttttccagag ctgaaggagt gaagagccct tggccatact   3240

agggctctcc ttcccccggg gagtgggaat tcagccacat tcagaattca catcgccttt   3300

gttatgtcca gaggagaggc ataaaaaggc actctccccc accaccccta ccgaatctgg   3360

gtttggtttg gttttattta actagcaaag ttaatccagt aatcgcaaat tactccagat   3420

ggttaaagaa aaccctttca gaatacagaa cgagaaaact agagtttgac caataagacc   3480

aatttctgcc atgaagaacc gggggacgca agttaattgt ttaacgtact ctcattttaa   3540

gcaccttctt tcctgtctct tgattgtttt ttctgaagga agtgtaaaga atgtctcagt   3600

ctgccttaaa ggaactgtga aggcttctct gtaatttaag cttgattgaa gtgaactgaa   3660

acattgtcta atgtctttgt ggctttagag cttttgttat attgtgccta taaagcaaat   3720

tatgtttaca taaaaatata aataaagtat tcagcatagc aaaaccccaa aaaaaaaaaa   3780

aaaa                                                                3784


<210>  3421
<211>  419
<212>  PRT
<213>  Homosapiens

<400>  3421

Met Ala Lys Glu Gly Val Glu Lys Ala Glu Glu Thr Glu Gln Met Ile 
1               5                   10                  15      


Glu Lys Glu Ala Gly Lys Glu Pro Ala Glu Gly Gly Gly Gly Asp Gly 
            20                  25                  30          


Ser His Arg Leu Gly Asp Ala Gln Glu Met Arg Ala Val Val Leu Ala 
        35                  40                  45              


Gly Phe Gly Gly Leu Asn Lys Leu Arg Leu Phe Arg Lys Ala Met Pro 
    50                  55                  60                  


Glu Pro Gln Asp Gly Glu Leu Lys Ile Arg Val Lys Ala Cys Gly Leu 
65                  70                  75                  80  


Asn Phe Ile Asp Leu Met Val Arg Gln Gly Asn Ile Asp Asn Pro Pro 
                85                  90                  95      


Lys Thr Pro Leu Val Pro Gly Phe Glu Cys Ser Gly Ile Val Glu Ala 
            100                 105                 110         


Leu Gly Asp Ser Val Lys Gly Tyr Glu Ile Gly Asp Arg Val Met Ala 
        115                 120                 125             


Phe Val Asn Tyr Asn Ala Trp Ala Glu Val Val Cys Thr Pro Val Glu 
    130                 135                 140                 


Phe Val Tyr Lys Ile Pro Asp Asp Met Ser Phe Ser Glu Ala Ala Ala 
145                 150                 155                 160 


Phe Pro Met Asn Phe Val Thr Ala Tyr Val Met Leu Phe Glu Val Ala 
                165                 170                 175     


Asn Leu Arg Glu Gly Met Ser Val Leu Val His Ser Ala Gly Gly Gly 
            180                 185                 190         


Val Gly Gln Ala Val Ala Gln Leu Cys Ser Thr Val Pro Asn Val Thr 
        195                 200                 205             


Val Phe Gly Thr Ala Ser Thr Phe Lys His Glu Ala Ile Lys Asp Ser 
    210                 215                 220                 


Val Thr His Leu Phe Asp Arg Asn Ala Asp Tyr Val Gln Glu Val Lys 
225                 230                 235                 240 


Arg Ile Ser Ala Glu Gly Val Asp Ile Val Leu Asp Cys Leu Cys Gly 
                245                 250                 255     


Asp Asn Thr Gly Lys Gly Leu Ser Leu Leu Lys Pro Leu Gly Thr Tyr 
            260                 265                 270         


Ile Leu Tyr Gly Ser Ser Asn Met Val Thr Gly Glu Thr Lys Ser Phe 
        275                 280                 285             


Phe Ser Phe Ala Lys Ser Trp Trp Gln Val Glu Lys Val Asn Pro Ile 
    290                 295                 300                 


Lys Leu Tyr Glu Glu Asn Lys Val Ile Ala Gly Phe Ser Leu Leu Asn 
305                 310                 315                 320 


Leu Leu Phe Lys Gln Gly Arg Ala Gly Leu Ile Arg Gly Val Val Glu 
                325                 330                 335     


Lys Leu Ile Gly Leu Tyr Asn Gln Lys Lys Ile Lys Pro Val Val Asp 
            340                 345                 350         


Ser Leu Trp Ala Leu Glu Glu Val Lys Glu Ala Met Gln Arg Ile His 
        355                 360                 365             


Asp Arg Gly Asn Ile Gly Lys Leu Ile Leu Asp Val Glu Lys Thr Pro 
    370                 375                 380                 


Thr Pro Leu Met Ala Asn Asp Ser Thr Glu Thr Ser Glu Ala Gly Glu 
385                 390                 395                 400 


Glu Glu Glu Asp His Glu Gly Asp Ser Glu Asn Lys Glu Arg Met Pro 
                405                 410                 415     


Phe Ile Gln 
            


<210>  3422
<211>  1303
<212>  DNA
<213>  Homosapiens

<400>  3422
gaagagacag cgccgccggc cgtggggagc ggacgcagtg atttgctccc cctcgtgcag     60

caacccccac acccagcacc aggagcctgt tcctctcacg ccctcacctg gctgagccgc    120

agtagttctt cagtggcaag ctttatgtcc tgacccagct aaagctgcca gttgaagaac    180

tgttgccctc tgcccctggc ttcgaggagg aggaggagct gctttcccca tcatctggaa    240

ggtgacagaa atgggctggg aaggtccgaa cagcagggtg gatgatacgt tttgggcaag    300

ttggagagcc tttgcccaga ttggcccagc aaggagcggt tttagattag agacactggc    360

tggattgagg agtagaaggc tcaaacaacc caaggctttc tgcctccgag atgtggcacc    420

atagtgcggt gccctgtggc ttcaccgccc tacttccacc tccgcccagc ctgtaatgtt    480

tatataagca gcctcaagga ccaagaacca tctgcgaaag gacacacaca ggaaattcat    540

aaaagaaatc tgaatggata aaaccatgaa aaaaagtatg cttcattagt aattaaagaa    600

aggcaaatag agctggaagc atttttccct tagcaaacca taacagaaaa aaataagacc    660

caatattggc aaagagacta ctgaaaaaac attcccatac attgcgtgtg ggagtataca    720

tcggtgcagg cttcctggat gacagttggg tgatatgtgt catgtggcct aaaagcctcc    780

atgtcatttg acctacgaat tctatctttg ggaatttatc ctaagaaaat acttaaggat    840

ttagttagtg ataagatgtt catcccagca ttgcaatgga gaaaaatggg aagcaatggt    900

ttggttggga atttattcct tttctgctgt aacgaaagtt tgcaataggg gattgcttaa    960

gtaaattatt gtatctccat ccagatggtg gagtaccgcg cagacattaa aagtcatgta   1020

aaagaacatc tgactgaaag aaaaatgctc cttgaatatt aaaaggttgt aaaaatagtg   1080

catgttatgt gatttcaatt ttgtttttta aaatatgggt gtatgcttgt atacgtagag   1140

cagataaaaa agacggaagg catactaaaa aatgttgagt ggttatcttt gtatggtgga   1200

acaaagtcac tgtaattttc atctttggtt tttctgtaat ttccaaattt tccacatttt   1260

gtatttcata taatataatt taagaaaaaa aaaaaaaaaa aaa                     1303


<210>  3423
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  3423

Met Gly Trp Glu Gly Pro Asn Ser Arg Val Asp Asp Thr Phe Trp Ala 
1               5                   10                  15      


Ser Trp Arg Ala Phe Ala Gln Ile Gly Pro Ala Arg Ser Gly Phe Arg 
            20                  25                  30          


Leu Glu Thr Leu Ala Gly Leu Arg Ser Arg Arg Leu Lys Gln Pro Lys 
        35                  40                  45              


Ala Phe Cys Leu Arg Asp Val Ala Pro 
    50                  55          


<210>  3424
<211>  1385
<212>  DNA
<213>  Homosapiens

<400>  3424
aagagacagc gccgccggcc gtggggagcg gacgcagtga tttgctcccc ctcgtgcagc     60

aacccccaca cccagcacca ggcccccaga actctccttc cagctgaact ccctgggaac    120

aagtcagttg ggctgatcac tgaactcaca tttctggacc tgaggagcct gttcctctca    180

cgccctcacc tggctgagcc gcagtagttc ttcagtggca agctttatgt cctgacccag    240

ctaaagctgc cagttgaaga actgttgccc tctgcccctg gcttcgagga ggaggaggag    300

ctgctttccc catcatctgg aaggtgacag aaatgggctg ggaaggtccg aacagcaggg    360

tggatgatac gttttgggca agttggagag cctttgccca gattggccca gcaaggagcg    420

gttttagatt agagacactg gctggattga ggagtagaag gctcaaacaa cccaaggctt    480

tctgcctccg agatgtggca ccatagtgcg gtgccctgtg gcttcaccgc cctacttcca    540

cctccgccca gcctgtaatg tttatataag cagcctcaag gaccaagaac catctgcgaa    600

aggacacaca caggaaattc ataaaagaaa tctgaatgga taaaaccatg aaaaaaagta    660

tgcttcatta gtaattaaag aaaggcaaat agagctggaa gcatttttcc cttagcaaac    720

cataacagaa aaaaataaga cccaatattg gcaaagagac tactgaaaaa acattcccat    780

acattgcgtg tgggagtata catcggtgca ggcttcctgg atgacagttg ggtgatatgt    840

gtcatgtggc ctaaaagcct ccatgtcatt tgacctacga attctatctt tgggaattta    900

tcctaagaaa atacttaagg atttagttag tgataagatg ttcatcccag cattgcaatg    960

gagaaaaatg ggaagcaatg gtttggttgg gaatttattc cttttctgct gtaacgaaag   1020

tttgcaatag gggattgctt aagtaaatta ttgtatctcc atccagatgg tggagtaccg   1080

cgcagacatt aaaagtcatg taaaagaaca tctgactgaa agaaaaatgc tccttgaata   1140

ttaaaaggtt gtaaaaatag tgcatgttat gtgatttcaa ttttgttttt taaaatatgg   1200

gtgtatgctt gtatacgtag agcagataaa aaagacggaa ggcatactaa aaaatgttga   1260

gtggttatct ttgtatggtg gaacaaagtc actgtaattt tcatctttgg tttttctgta   1320

atttccaaat tttccacatt ttgtatttca tataatataa tttaagaaaa aaaaaaaaaa   1380

aaaaa                                                               1385


<210>  3425
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  3425

Met Gly Trp Glu Gly Pro Asn Ser Arg Val Asp Asp Thr Phe Trp Ala 
1               5                   10                  15      


Ser Trp Arg Ala Phe Ala Gln Ile Gly Pro Ala Arg Ser Gly Phe Arg 
            20                  25                  30          


Leu Glu Thr Leu Ala Gly Leu Arg Ser Arg Arg Leu Lys Gln Pro Lys 
        35                  40                  45              


Ala Phe Cys Leu Arg Asp Val Ala Pro 
    50                  55          


<210>  3426
<211>  3789
<212>  DNA
<213>  Homosapiens

<400>  3426
aaagagcagg cgaaagccac ggcgtctgcg tttgcaatgc atgctggtcc gtgtagttct     60

cagcctgaca ccgtcgttcc cagaacccag cgcgctctgt gctggcgggc gcagaggcct    120

cccaggagga gagcaaggac ctggcagggg ctgctgagga ggagagcggg ctgcccgggg    180

ccgggcctgg ctcctgtgct tttggggagg agattcccat ggatggggag cctcctgcct    240

cctcgggcct ggggctccca gactacacgt ctggcgtcag cttccacgac caggctgacc    300

tccctgagac agaggacttc caagccgggc tctatgtgac tgagtctccc cagccccagg    360

aggctgaggc tgtgagcctg ggccggctga gtgacaagag cagcaccagc gagacctccc    420

tgggtgagga gcgggctcca gacgaggggg gtgcccccgt ggacaagagc agccttcgat    480

caggtgacag cagccaggac ttgaagcaaa gcgagggctc cgaggaggaa gaggaggagg    540

aggacagctg cgtggtgcta gaggaggagg agggggagca ggaggaggtc accggggcat    600

ctgagctcac tctgtctgac acggtgctgt ccatggagac ggttgtggcc ggcggcagtg    660

ggggagatgg agaagaagag gaggaggcac tgcctgagca gtcagaaggc aaagaacaga    720

agatcctcct tgatacagcc tgcaagatgg tccgctggct gtctgccaag ctcggcccca    780

cagtggcctc tcgccacgtg gcccggaacc tgctccgcct gctgacgtct tgttatgttg    840

gacccactcg gcagcagttc acagtgagca gtggcgagag cccaccgctg agcgccggca    900

acatctacca gaagaggccg gtcctgggcg acatcgtgtc agggcctgtg ctcagctacc    960

tcctccacat cgcccgcctg tatggggagc ctgtcctcac ctaccagtac ctgccctaca   1020

tcagctacct ggtggcccca gggagtgcct caggccccag ccgactgaac agccgtaagg   1080

aggcggggct gctggccgcg gtgacgctga ctcagaagat catcgtgtac ctctcagaca   1140

ccacactcat ggacatcctg ccccggatca gccatgaggt cctgctgccc gtgctcagct   1200

tcctcacctc cctcgtcacg gggttcccaa gtggggccca ggctcggacc atcctgtgtg   1260

tgaaaaccat cagcctcatc gccctcatct gcctgcgcat tggacaggag atggtccagc   1320

agcacctgag cgagcccgtg gccacctttt tccaggtctt ctctcagctg catgagcttc   1380

ggcaacagga tctgaagctg gaccctgcgg gccgtggtga gggccagctg ccacaggtgg   1440

tcttctctga tgggcagcag cggcccgtgg accccgccct gctggacgag ctgcagaagg   1500

tgttcaccct ggagatggca tacacaatct acgtgccctt ctcctgcctg ttgggtgaca   1560

tcatccggaa aatcatcccc aaccacgagc tggttgggga gctggcggcg ctgtacttgg   1620

agagcatcag ccccagcagt cgcaaccctg ccagcgtgga gcccaccatg cccggcaccg   1680

ggcccgagtg ggacccccat ggtgggggct gccctcagga tgacggccac tcagggacct   1740

ttgggagcgt cctggtgggg aaccgcattc agatccccaa tgactctcgg cctgagaacc   1800

ccggaccact gggccccatc tcgggggtgg gtggcggggg cctgggcagc gggagcgacg   1860

acaacgccct gaagcaggag ctgccgcgga gcgtgcacgg gctgagcgga aactggctgg   1920

cgtactggca gtacgagatc ggcgtgagcc agcaggatgc ccactttcac ttccaccaga   1980

tccgcctgca gagcttcccg ggccactcgg gggccgtcaa gtgcgtggca cccctgagca   2040

gcgaggactt cttcctgagc ggcagcaagg atcgtaccgt gcgcctctgg ccgctgtaca   2100

actacggcga cgggaccagc gagacggccc cacgcctcgt ctacacccag caccgcaaga   2160

gcgtcttctt cgtgggccag cttgaggccc cacagcacgt ggtgagctgt gacggggctg   2220

tgcacgtctg ggaccccttc acagggaaga cccttcgcac agtggagccg ctggacagcc   2280

gggtgcccct gactgcggtg gctgtcatgc ccgcccccca caccagcatc accatggcca   2340

gcactgactc taccctgcgc tttgtggact gcaggaagcc tggtctgcag tacgagttcc   2400

gactgggcgg tgggctgaac cctgggcttg tccgtgccct ggccatcagc cccagtggcc   2460

gtagtgtcgt ggccggcttc tcctcaggct tcatggtgct cctggacacc cgcacgggcc   2520

tggttctgcg aggctggcca gcccacgagg gggacattct gcagatcaag gcggtggagg   2580

gcagcgtcct ggtcagctcc tcctctgacc attccttgac cgtctggaag gagctggagc   2640

agaagcccac ccatcactac aagtcagcat ccgaccccat ccacaccttt gacctgtacg   2700

gcagtgaggt ggtcactggc accgtgtcca acaagattgg cgtctgctcc ctgcttgagc   2760

caccctcgca ggccaccacg aagctcagct ctgagaactt ccgcggcacg ctcaccagcc   2820

tggccttgct gcccactaaa cgccacctcc tgctgggctc agacaacggg gttatccgcc   2880

tcctggcata gactgaggca ggagctggcc gggcaagggt gggaagacat ctgcgggcgc   2940

gtgtccgctc accctgttcc ctgagcagca gctccctcca gggaggccct gggtcccacg   3000

ccctgggtgc ccacatggcc tgccaactag ggcctgcaaa tggagtgggg gagtcctggc   3060

ccctgaatca ccagagccac caagcctgcc agaggggtcc cattcatggc ttggggacac   3120

agggctccta gcaagcagga agttaagagc aggaggaagc gttgctacct tcacttctcc   3180

ccagctctgc cctctgggtc cacatgagga cagggaagct cgggaagggg aagggagact   3240

ggccctgccc agccggtctc tagcccctca gcccccgctg ggcactctct gtcccatccc   3300

tctaggacag ggaagctggc ctggtccagg gcactgatgg tgcttggatt ccagcctaag   3360

gaaggctggc cgtggtccag gagttaaggg cttgggtctg gggtttaagt ggccacccat   3420

ccaggccctg gccagtgtgg gaccgggacg ggaaggaaga aggaggctag gagcaggggg   3480

aaaaggtgca cttggccagt ggcgcctgcc aggagtgagt ccatgcgttg tctgcccacc   3540

cctaccacag tgtttgtgcc ttcagctgag ggggcagcct ctgggccctg aacccctgct   3600

ggggctccac gaccctgaga gaagggttga gaagaatcat ctctgcacct cgggtctctg   3660

ccagaggaag acttaagcat ccctgcgacc tcacattcta gacagagatg aggtccaagg   3720

gttggcccct gctgccttct cacaatttgc aatagatgta aataggacca ataaatcctt   3780

tggaagagc                                                           3789


<210>  3427
<211>  890
<212>  PRT
<213>  Homosapiens

<400>  3427

Met Asp Gly Glu Pro Pro Ala Ser Ser Gly Leu Gly Leu Pro Asp Tyr 
1               5                   10                  15      


Thr Ser Gly Val Ser Phe His Asp Gln Ala Asp Leu Pro Glu Thr Glu 
            20                  25                  30          


Asp Phe Gln Ala Gly Leu Tyr Val Thr Glu Ser Pro Gln Pro Gln Glu 
        35                  40                  45              


Ala Glu Ala Val Ser Leu Gly Arg Leu Ser Asp Lys Ser Ser Thr Ser 
    50                  55                  60                  


Glu Thr Ser Leu Gly Glu Glu Arg Ala Pro Asp Glu Gly Gly Ala Pro 
65                  70                  75                  80  


Val Asp Lys Ser Ser Leu Arg Ser Gly Asp Ser Ser Gln Asp Leu Lys 
                85                  90                  95      


Gln Ser Glu Gly Ser Glu Glu Glu Glu Glu Glu Glu Asp Ser Cys Val 
            100                 105                 110         


Val Leu Glu Glu Glu Glu Gly Glu Gln Glu Glu Val Thr Gly Ala Ser 
        115                 120                 125             


Glu Leu Thr Leu Ser Asp Thr Val Leu Ser Met Glu Thr Val Val Ala 
    130                 135                 140                 


Gly Gly Ser Gly Gly Asp Gly Glu Glu Glu Glu Glu Ala Leu Pro Glu 
145                 150                 155                 160 


Gln Ser Glu Gly Lys Glu Gln Lys Ile Leu Leu Asp Thr Ala Cys Lys 
                165                 170                 175     


Met Val Arg Trp Leu Ser Ala Lys Leu Gly Pro Thr Val Ala Ser Arg 
            180                 185                 190         


His Val Ala Arg Asn Leu Leu Arg Leu Leu Thr Ser Cys Tyr Val Gly 
        195                 200                 205             


Pro Thr Arg Gln Gln Phe Thr Val Ser Ser Gly Glu Ser Pro Pro Leu 
    210                 215                 220                 


Ser Ala Gly Asn Ile Tyr Gln Lys Arg Pro Val Leu Gly Asp Ile Val 
225                 230                 235                 240 


Ser Gly Pro Val Leu Ser Tyr Leu Leu His Ile Ala Arg Leu Tyr Gly 
                245                 250                 255     


Glu Pro Val Leu Thr Tyr Gln Tyr Leu Pro Tyr Ile Ser Tyr Leu Val 
            260                 265                 270         


Ala Pro Gly Ser Ala Ser Gly Pro Ser Arg Leu Asn Ser Arg Lys Glu 
        275                 280                 285             


Ala Gly Leu Leu Ala Ala Val Thr Leu Thr Gln Lys Ile Ile Val Tyr 
    290                 295                 300                 


Leu Ser Asp Thr Thr Leu Met Asp Ile Leu Pro Arg Ile Ser His Glu 
305                 310                 315                 320 


Val Leu Leu Pro Val Leu Ser Phe Leu Thr Ser Leu Val Thr Gly Phe 
                325                 330                 335     


Pro Ser Gly Ala Gln Ala Arg Thr Ile Leu Cys Val Lys Thr Ile Ser 
            340                 345                 350         


Leu Ile Ala Leu Ile Cys Leu Arg Ile Gly Gln Glu Met Val Gln Gln 
        355                 360                 365             


His Leu Ser Glu Pro Val Ala Thr Phe Phe Gln Val Phe Ser Gln Leu 
    370                 375                 380                 


His Glu Leu Arg Gln Gln Asp Leu Lys Leu Asp Pro Ala Gly Arg Gly 
385                 390                 395                 400 


Glu Gly Gln Leu Pro Gln Val Val Phe Ser Asp Gly Gln Gln Arg Pro 
                405                 410                 415     


Val Asp Pro Ala Leu Leu Asp Glu Leu Gln Lys Val Phe Thr Leu Glu 
            420                 425                 430         


Met Ala Tyr Thr Ile Tyr Val Pro Phe Ser Cys Leu Leu Gly Asp Ile 
        435                 440                 445             


Ile Arg Lys Ile Ile Pro Asn His Glu Leu Val Gly Glu Leu Ala Ala 
    450                 455                 460                 


Leu Tyr Leu Glu Ser Ile Ser Pro Ser Ser Arg Asn Pro Ala Ser Val 
465                 470                 475                 480 


Glu Pro Thr Met Pro Gly Thr Gly Pro Glu Trp Asp Pro His Gly Gly 
                485                 490                 495     


Gly Cys Pro Gln Asp Asp Gly His Ser Gly Thr Phe Gly Ser Val Leu 
            500                 505                 510         


Val Gly Asn Arg Ile Gln Ile Pro Asn Asp Ser Arg Pro Glu Asn Pro 
        515                 520                 525             


Gly Pro Leu Gly Pro Ile Ser Gly Val Gly Gly Gly Gly Leu Gly Ser 
    530                 535                 540                 


Gly Ser Asp Asp Asn Ala Leu Lys Gln Glu Leu Pro Arg Ser Val His 
545                 550                 555                 560 


Gly Leu Ser Gly Asn Trp Leu Ala Tyr Trp Gln Tyr Glu Ile Gly Val 
                565                 570                 575     


Ser Gln Gln Asp Ala His Phe His Phe His Gln Ile Arg Leu Gln Ser 
            580                 585                 590         


Phe Pro Gly His Ser Gly Ala Val Lys Cys Val Ala Pro Leu Ser Ser 
        595                 600                 605             


Glu Asp Phe Phe Leu Ser Gly Ser Lys Asp Arg Thr Val Arg Leu Trp 
    610                 615                 620                 


Pro Leu Tyr Asn Tyr Gly Asp Gly Thr Ser Glu Thr Ala Pro Arg Leu 
625                 630                 635                 640 


Val Tyr Thr Gln His Arg Lys Ser Val Phe Phe Val Gly Gln Leu Glu 
                645                 650                 655     


Ala Pro Gln His Val Val Ser Cys Asp Gly Ala Val His Val Trp Asp 
            660                 665                 670         


Pro Phe Thr Gly Lys Thr Leu Arg Thr Val Glu Pro Leu Asp Ser Arg 
        675                 680                 685             


Val Pro Leu Thr Ala Val Ala Val Met Pro Ala Pro His Thr Ser Ile 
    690                 695                 700                 


Thr Met Ala Ser Thr Asp Ser Thr Leu Arg Phe Val Asp Cys Arg Lys 
705                 710                 715                 720 


Pro Gly Leu Gln Tyr Glu Phe Arg Leu Gly Gly Gly Leu Asn Pro Gly 
                725                 730                 735     


Leu Val Arg Ala Leu Ala Ile Ser Pro Ser Gly Arg Ser Val Val Ala 
            740                 745                 750         


Gly Phe Ser Ser Gly Phe Met Val Leu Leu Asp Thr Arg Thr Gly Leu 
        755                 760                 765             


Val Leu Arg Gly Trp Pro Ala His Glu Gly Asp Ile Leu Gln Ile Lys 
    770                 775                 780                 


Ala Val Glu Gly Ser Val Leu Val Ser Ser Ser Ser Asp His Ser Leu 
785                 790                 795                 800 


Thr Val Trp Lys Glu Leu Glu Gln Lys Pro Thr His His Tyr Lys Ser 
                805                 810                 815     


Ala Ser Asp Pro Ile His Thr Phe Asp Leu Tyr Gly Ser Glu Val Val 
            820                 825                 830         


Thr Gly Thr Val Ser Asn Lys Ile Gly Val Cys Ser Leu Leu Glu Pro 
        835                 840                 845             


Pro Ser Gln Ala Thr Thr Lys Leu Ser Ser Glu Asn Phe Arg Gly Thr 
    850                 855                 860                 


Leu Thr Ser Leu Ala Leu Leu Pro Thr Lys Arg His Leu Leu Leu Gly 
865                 870                 875                 880 


Ser Asp Asn Gly Val Ile Arg Leu Leu Ala 
                885                 890 


<210>  3428
<211>  2287
<212>  DNA
<213>  Homosapiens

<400>  3428
gaattccggc tggcagggga gaacatggcg ctgctctggg ggctcctggt gctcagctgg     60

tcctgcctgc aaggcccctg ctccgtgttc tcccctgtga gcgccatgga gcccttgggc    120

tggcagctaa ctagcgggcc gaaccaggag caggtgtccc cacttaccct cctcaagttg    180

ggcaaccagg agcctggtgg ccagactgcc ctgaagagtc ccccaggagt ctgcagcaga    240

gaccccaccc cagagcagac ccacaggctg gcccgggcca tgatggcctt cactgccgac    300

ctgttctccc tggtggctca aacgtccacc tgccccaacc tcatcctgtc acccctgagt    360

gtggccctgg cgctgtctca cctggcacta ggtgctcaga accacacgtt gcagaggctg    420

caacaggtgc tgcacgcagg ctcagggccc tgcctccccc atctgctgag ccgcctctgc    480

caggacctgg gccccggcgc gttccgactg gctgccagga tgtacctgca gaaaggattt    540

cccatcaaag aagatttcct ggaacaatcc gaacagctat ttggggcaaa gcccgtgagc    600

ctgacgggaa agcaggaaga tgacctggca aacatcaacc aatgggtgaa ggaggccacg    660

gaggggaaga ttcaggaatt cctctctggg ctgccggaag acaccgtgtt gcttctcctc    720

aacgccatcc acttccaggg tttctggagg aacaagtttg acccgagcct tacccagaga    780

gactccttcc acctggacga gcagttcacg gtgcccgtgg aaatgatgca ggcccgcacg    840

tacccgctgc gctggttctt gctggagcag cctgagatcc aggtggctca tttccccttt    900

aagaacaaca tgagctttgt ggtccttgta cccacccact ttgaatggaa cgtgtcccag    960

gtactggcca acctgagttg ggacaccctg cacccacctc tggtgtggga gaggcccacc   1020

aaggtccggc tgcctaagct gtatctgaaa caccaaatgg acctggtggc caccctcagc   1080

cagctgggcc tgcaggagtt gttccaggcc ccagacctgc gtgggatctc cgagcagagc   1140

ctggtggtgt ccggcgtgca gcatcagtcc accctggagc tcagcgaggt cggcgtggag   1200

gcggcggcgg ccaccagcat tgccatgtcc cgcatgtccc tgtcctcctt cagcgtgaac   1260

cgccccttcc tcttcttcat cttcgaggac accacaggcc ttcccctctt cgtgggcagc   1320

gtgaggaacc ccaaccccag tgcaccgcgg gagctcaagg aacagcagga ttccccgggc   1380

aacaaggact tcctccagag cctgaaaggc ttcccccgcg gagacaagct tttcggccct   1440

gacttaaaac ttgtgccccc catggaggag gattaccccc agtttggcag ccccaagtga   1500

ggggccgtgg ctgtggcatc cagactccct gcctggacca gcctctccac tcatgtgact   1560

ctttccaacc tgctttgtgg cactggggca ggggccgggg gcagtctgag agaggccatt   1620

ctttcccaac acctcttggg gagtttaggg tggggggggg cgcggctggg aggagggcag   1680

gcatcgggga gccgggagcc tgaccctcat ctttcttcca aacaggctca gagggtgtcc   1740

tgcaccgggg cctgggcagg agggaggtgc ttctagttct gccaggagac aggttagctg   1800

ctccccacgt cagctgggac accccgactt ttgtttacca gagaaaaagg gagggggaga   1860

gggctgcctt tggacttgtc ccgggacacc taggctaggg tggggagaga cgggccctgg   1920

tggtggctcg ggaggcgaag cgttgtcctc agccccgcgt ggaactcgtg tctggcacag   1980

cctggctgtg gcctaacctg ccgagagtcc atcagcctcc atcctacccc ctgtgccttg   2040

tcacgccaga cttcccacgg ctcctcgaga tcccaacact gccagcattt cccttccttc   2100

ctctcctgtc tccctcctct gcccgggagc tcaggaaccg aggcagggaa ggatcccatg   2160

agctccttaa ggctcttttg taaggttttt gtagtgattt ttatgccacc tgaataaaga   2220

atgaatgggc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2280

ggaattc                                                             2287


<210>  3429
<211>  491
<212>  PRT
<213>  Homosapiens

<400>  3429

Met Ala Leu Leu Trp Gly Leu Leu Val Leu Ser Trp Ser Cys Leu Gln 
1               5                   10                  15      


Gly Pro Cys Ser Val Phe Ser Pro Val Ser Ala Met Glu Pro Leu Gly 
            20                  25                  30          


Trp Gln Leu Thr Ser Gly Pro Asn Gln Glu Gln Val Ser Pro Leu Thr 
        35                  40                  45              


Leu Leu Lys Leu Gly Asn Gln Glu Pro Gly Gly Gln Thr Ala Leu Lys 
    50                  55                  60                  


Ser Pro Pro Gly Val Cys Ser Arg Asp Pro Thr Pro Glu Gln Thr His 
65                  70                  75                  80  


Arg Leu Ala Arg Ala Met Met Ala Phe Thr Ala Asp Leu Phe Ser Leu 
                85                  90                  95      


Val Ala Gln Thr Ser Thr Cys Pro Asn Leu Ile Leu Ser Pro Leu Ser 
            100                 105                 110         


Val Ala Leu Ala Leu Ser His Leu Ala Leu Gly Ala Gln Asn His Thr 
        115                 120                 125             


Leu Gln Arg Leu Gln Gln Val Leu His Ala Gly Ser Gly Pro Cys Leu 
    130                 135                 140                 


Pro His Leu Leu Ser Arg Leu Cys Gln Asp Leu Gly Pro Gly Ala Phe 
145                 150                 155                 160 


Arg Leu Ala Ala Arg Met Tyr Leu Gln Lys Gly Phe Pro Ile Lys Glu 
                165                 170                 175     


Asp Phe Leu Glu Gln Ser Glu Gln Leu Phe Gly Ala Lys Pro Val Ser 
            180                 185                 190         


Leu Thr Gly Lys Gln Glu Asp Asp Leu Ala Asn Ile Asn Gln Trp Val 
        195                 200                 205             


Lys Glu Ala Thr Glu Gly Lys Ile Gln Glu Phe Leu Ser Gly Leu Pro 
    210                 215                 220                 


Glu Asp Thr Val Leu Leu Leu Leu Asn Ala Ile His Phe Gln Gly Phe 
225                 230                 235                 240 


Trp Arg Asn Lys Phe Asp Pro Ser Leu Thr Gln Arg Asp Ser Phe His 
                245                 250                 255     


Leu Asp Glu Gln Phe Thr Val Pro Val Glu Met Met Gln Ala Arg Thr 
            260                 265                 270         


Tyr Pro Leu Arg Trp Phe Leu Leu Glu Gln Pro Glu Ile Gln Val Ala 
        275                 280                 285             


His Phe Pro Phe Lys Asn Asn Met Ser Phe Val Val Leu Val Pro Thr 
    290                 295                 300                 


His Phe Glu Trp Asn Val Ser Gln Val Leu Ala Asn Leu Ser Trp Asp 
305                 310                 315                 320 


Thr Leu His Pro Pro Leu Val Trp Glu Arg Pro Thr Lys Val Arg Leu 
                325                 330                 335     


Pro Lys Leu Tyr Leu Lys His Gln Met Asp Leu Val Ala Thr Leu Ser 
            340                 345                 350         


Gln Leu Gly Leu Gln Glu Leu Phe Gln Ala Pro Asp Leu Arg Gly Ile 
        355                 360                 365             


Ser Glu Gln Ser Leu Val Val Ser Gly Val Gln His Gln Ser Thr Leu 
    370                 375                 380                 


Glu Leu Ser Glu Val Gly Val Glu Ala Ala Ala Ala Thr Ser Ile Ala 
385                 390                 395                 400 


Met Ser Arg Met Ser Leu Ser Ser Phe Ser Val Asn Arg Pro Phe Leu 
                405                 410                 415     


Phe Phe Ile Phe Glu Asp Thr Thr Gly Leu Pro Leu Phe Val Gly Ser 
            420                 425                 430         


Val Arg Asn Pro Asn Pro Ser Ala Pro Arg Glu Leu Lys Glu Gln Gln 
        435                 440                 445             


Asp Ser Pro Gly Asn Lys Asp Phe Leu Gln Ser Leu Lys Gly Phe Pro 
    450                 455                 460                 


Arg Gly Asp Lys Leu Phe Gly Pro Asp Leu Lys Leu Val Pro Pro Met 
465                 470                 475                 480 


Glu Glu Asp Tyr Pro Gln Phe Gly Ser Pro Lys 
                485                 490     


<210>  3430
<211>  1542
<212>  DNA
<213>  Homosapiens

<400>  3430
ggtcgcttta agaaaggagt agctgtaatc tgaagcctgc tggacgctgg attagaaggc     60

agcaaaaaaa gctctgtgct ggctggagcc ccctcagtgt gcaggcttag agggactagg    120

ctgggtgtgg agctgcagcg tatccacagg ccccaggatg caggccctgg tgctactcct    180

ctgcattgga gccctcctcg ggcacagcag ctgccagaac cctgccagcc ccccggagga    240

gggctcccca gaccccgaca gcacaggggc gctggtggag gaggaggatc ctttcttcaa    300

agtccccgtg aacaagctgg cagcggctgt ctccaacttc ggctatgacc tgtaccgggt    360

gcgatccagc acgagcccca cgaccaacgt gctcctgtct cctctcagtg tggccacggc    420

cctctcggcc ctctcgctgg gagcggagca gcgaacagaa tccatcattc accgggctct    480

ctactatgac ttgatcagca gcccagacat ccatggtacc tataaggagc tccttgacac    540

ggtcactgcc ccccagaaga acctcaagag tgcctcccgg atcgtctttg agaagaagct    600

gcgcataaaa tccagctttg tggcacctct ggaaaagtca tatgggacca ggcccagagt    660

cctgacgggc aaccctcgct tggacctgca agagatcaac aactgggtgc aggcgcagat    720

gaaagggaag ctcgccaggt ccacaaagga aattcccgat gagatcagca ttctccttct    780

cggtgtggcg cacttcaagg ggcagtgggt aacaaagttt gactccagaa agacttccct    840

cgaggatttc tacttggatg aagagaggac cgtgagggtc cccatgatgt cggaccctaa    900

ggctgtttta cgctatggct tggattcaga tctcagctgc aagattgccc agctgccctt    960

gaccggaagc atgagtatca tcttcttcct gcccctgaaa gtgacccaga atttgacctt   1020

gatagaggag agcctcacct ccgagttcat tcatgacata gaccgagaac tgaagaccgt   1080

gcaggcggtc ctcactgtcc ccaagctgaa gctgagttat gaaggcgaag tcaccaagtc   1140

cctgcaggag atgaagctgc aatccttgtt tgattcacca gactttagca agatcacagg   1200

caaacccatc aagctgactc aggtggaaca ccgggctggc tttgagtgga acgaggatgg   1260

ggcgggaacc acccccagcc cagggctgca gcctgcccac ctcaccttcc cgctggacta   1320

tcaccttaac cagcctttca tcttcgtact gagggacaca gacacagggg cccttctctt   1380

cattggcaag attctggacc ccaggggccc ctaatatccc agtttaatat tccaataccc   1440

tagaagaaaa cccgagggac agcagattcc acaggacacg aaggctgccc ctgtaaggtt   1500

tcaatgcata caataaaaga gctttatccc taacttctgt ta                      1542


<210>  3431
<211>  418
<212>  PRT
<213>  Homosapiens

<400>  3431

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp 
            20                  25                  30          


Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys 
        35                  40                  45              


Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp 
    50                  55                  60                  


Leu Tyr Arg Val Arg Ser Ser Thr Ser Pro Thr Thr Asn Val Leu Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 
                85                  90                  95      


Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 
            100                 105                 110         


Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 
        115                 120                 125             


Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe 
    130                 135                 140                 


Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys 
145                 150                 155                 160 


Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp 
                165                 170                 175     


Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu 
            180                 185                 190         


Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 
        195                 200                 205             


Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 
    210                 215                 220                 


Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 
225                 230                 235                 240 


Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp 
                245                 250                 255     


Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met 
            260                 265                 270         


Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu 
        275                 280                 285             


Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu 
    290                 295                 300                 


Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser 
305                 310                 315                 320 


Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 
                325                 330                 335     


Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 
            340                 345                 350         


Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 
        355                 360                 365             


Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe 
    370                 375                 380                 


Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp 
385                 390                 395                 400 


Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg 
                405                 410                 415     


Gly Pro 
        


<210>  3432
<211>  4269
<212>  DNA
<213>  Homosapiens

<400>  3432
agtcgagggc gcagttcagg gcgcgtctga gcggttctcg aggcgttctc gcctcggtct     60

ctggcgagtg cacggatcaa aagcagcatg gatctgcctg tggatgagtg gaaatcatat    120

ctgcttcaaa agtgggcttc actcccgacg tctgttcagg tcacaatttc tacagcagag    180

accttgaggg atatctttct tcactcctct tcacttcttc aacctgagga tgagctgttt    240

ctaaaaagac tttctaaagg ttacttggtg ggaaaggact cggacgctcc tcttttctac    300

agagaagaag gaaacaaaaa atttcaggag aaagattaca caggagctgc agtgctgtac    360

tctaagggag tgtcacattc aaggcctaac actgaggaca tgtcactgtg tcatgctaac    420

cgctcggcag ccctcttcca cctgggtcag tatgagacgt gtcttaaaga cattaacata    480

gcacagacac atgggtatcc agaaaggttg caacccaaga ttatgttacg taaagcagaa    540

tgtctggtgg ccctggggag actgcaggag gcaagccaga ccatcagtga tcttgaaagg    600

aacttcacag ccacaccagc cctagcagat gtcctccctc agactctgca gagaaacctc    660

catcgtctga aaatgaagat gcaagaaaag gacagtctca cagaaagctt cccagcagct    720

ctggccaaaa cccttgagga tgcagcgctg agggaggaga atgaacaact ttccaatgcc    780

tcatcatcca tcggcttatg cgtagatcct ttaaaaggtc gctgtctcgt tgccacaaaa    840

gatattctcc caggagagct cctggtgcag gaggatgctt ttgtgagtgt tctcaaccca    900

ggagaactgc caccaccgca tcacggccta gacagcaaat gggacaccag agtcaccaat    960

ggggacctct attgtcaccg atgtttgaag cacactttgg ccacagttcc gtgtgacgga   1020

tgcagttatg ccaagtattg cagccaggag tgtttgcagc aggtctggga gctctaccac   1080

aggacagaat gtcctctggg agggctgctt ctcacactgg gtgtcttttg ccacattgcc   1140

ctgaggttga ctcttttggt gggatttgag gatgttcgca aaatcataac gaagctttgt   1200

gataagatta gtaacaagga catctgttta cctgaaagca acaatcaggt caagacactt   1260

aattatggcc taggggagag tgagaaaaat ggcaacatcg ttgagacccc aattcctgga   1320

tgcgatatta atgggaagta tgaaaataat tataatgctg tcttcaacct tttgccccac   1380

actgaaaacc atagcccaga gcacaaattc ctctgtgctc tctgtgtttc tgcactgtgc   1440

agacagctag aagcagccag tttacaggcc atcccaactg agaggattgt gaactcctct   1500

cagcttaaag cagcagtgac acctgaattg tgtcctgacg tgactatttg gggagtggcg   1560

atgctgagac acatgttaca gcttcagtgt aacgctcagg cgatgaccac catacaacac   1620

acaggaccta aagggagcat cgttaccgac agcaggcagg tgcgccttgc cacaggcatc   1680

ttccctgtta tcagcctcct gaaccactcc tgtagcccca acaccagcgt gtccttcatt   1740

agcactgtcg ccaccatccg ggcgtcacag cggattagaa aggggcaaga gattctccac   1800

tgctatgggc ctcacaagag ccggatgggg gttgccgaaa ggcagcagaa gctgaggtct   1860

cagtatttct ttgactgcgc ctgtccagct tgtcaaactg aggcacacag gatggctgca   1920

gggcccaggt gggaagcatt ctgttgcaac agttgcggag cgcccatgca gggagatgac   1980

gtgctgcgct gtggcagcag atcttgtgca gaatccgccg tcagcaggga ccacctggtc   2040

tctcggttac aggacctaca gcagcaggtc agagtggccc agaagcttct cagagatggt   2100

gaactagagc gagctgttca gcggctgtcg gggtgccagc gtgacgccga gagcttcctg   2160

tgggcagagc acgccgtggt gggagagatc gcggatggcc tggcccgggc ctgtgctgcc   2220

ttaggagact ggcaaaagtc agccacccat ctacagagga gtctctgcgt ggtggaggtt   2280

cgccacgggc cgtccagtgt tgaaatgggc catgagctct tcaaattggc ccagatcttt   2340

ttcaacgggt ttgcagtacc cgaagccctg agcacaatac agaaagctga ggaggttctg   2400

tcgctgcact gtggcccatg ggacgatgaa atccaggagc tccagaagat gaaatcctgt   2460

ttgttggact taccacccac ccctgtaggg cctgcattgt agggttccag gaggattttg   2520

acccacagaa aaggagccca tggaacacaa gttaaagagg ttttgctggc caggtatggt   2580

ggctcacgcc tgtaatccca gcactttggg aggctaaggt gggcggatca cctgatgtcg   2640

ggagttcaag accagcctgg ccaacatggt gaaaccccat ctttactaaa aatacaaaaa   2700

actagccagg cgtggtggtg ggcacctgta atcccagcta cttgggaggc tgaggcagga   2760

gaatctcttg aacccgggag gcggaggttg cagtgagccg agatcgctcc actgcactcc   2820

agcccaggtg acagtgtgag actccatctc aaaaaaaaaa ataagaggcc gggtgcggtg   2880

gctcaagcct gtaatcccag cactttggga ggccgaggca ggcagatcac gaggtcagga   2940

gatccagacc atcctggcta acacggtgaa accccgtctc tactaaaaat acaaaaaaat   3000

tagtcgggcg tggtggcgga cgcctgtatt cacagctact cgggaggttg aggcaggaga   3060

atggggtgaa cccgggagga agagcttgca gtgagccgag atcgcgccac tgcactccag   3120

cctgggtgac agagccagac tccatctcaa agaaaaaaaa aaaatattaa gaggttctgc   3180

tgccagatgt gggttctgtg ggtcgggtgt gggttctgtg ggtcgggtgt gggttctgca   3240

gaccaggtgc ggattctgtg taggttctgc aggcccagtg tagaggctca cacctgtaat   3300

cccagtactt tgagacgctg aggtgggggg atcacttgag cccaggagtt caaaaccagc   3360

ctgggcaata tagtgagacc gtatcactac aaaaaagttt ttttagttca ccgagcatgg   3420

tggcacatgc ctgtagtccc acctactcga gaagctgaga tagggtcacc tgagcctggt   3480

aggctgaggc tgcagtgagc caagatcgca ctactgcact ccagcctggg tgacagagta   3540

agaccctgtc tcaacaaaaa aataacaggt tctgttgctg ctgagctttc gtcaggaaga   3600

taagactttc ccaacagtcc gaagcctagg atatgagggc tgaggaggac tcaaaccgtt   3660

gcagtcagag agacacctat tttggtgaat attttttgaa atagttaagt ggcctccagt   3720

acaaactccc agttcccaga aaagacttaa aactagtatc tggagattcc aagtccttta   3780

aaaggatttt agctgatctg caggcatctg gatgttagcc tggggttttg gctggattcc   3840

acctcgctca gtgatgatag tctgtttccc tggaacattc ctgtggtttt agtagtaatg   3900

agatgtgtgc accactccag tgggaactga agctcttagt agttacattg taattaaaaa   3960

agaattataa aacaagaaat cagcaagcct gcttacctcc agagacacac cgttccactt   4020

acagtatcta gcttcctcga ctcctttgtt aaaatcgtgg agtatgaacc gtgaccagag   4080

aagtaaatat ggagcagttt tattgagcag tttcctccag ggatgacggc tgtcagtgtg   4140

tttcctgcca gttttccagt ccttactctc tgcccttcat tctgtactct tggcagagtc   4200

agtaaccaac cactaataaa atcaaagttg tagtaaaaaa aaaaaaaaaa aagaaaaaaa   4260

aaaaaaaaa                                                           4269


<210>  3433
<211>  804
<212>  PRT
<213>  Homosapiens

<400>  3433

Met Asp Leu Pro Val Asp Glu Trp Lys Ser Tyr Leu Leu Gln Lys Trp 
1               5                   10                  15      


Ala Ser Leu Pro Thr Ser Val Gln Val Thr Ile Ser Thr Ala Glu Thr 
            20                  25                  30          


Leu Arg Asp Ile Phe Leu His Ser Ser Ser Leu Leu Gln Pro Glu Asp 
        35                  40                  45              


Glu Leu Phe Leu Lys Arg Leu Ser Lys Gly Tyr Leu Val Gly Lys Asp 
    50                  55                  60                  


Ser Asp Ala Pro Leu Phe Tyr Arg Glu Glu Gly Asn Lys Lys Phe Gln 
65                  70                  75                  80  


Glu Lys Asp Tyr Thr Gly Ala Ala Val Leu Tyr Ser Lys Gly Val Ser 
                85                  90                  95      


His Ser Arg Pro Asn Thr Glu Asp Met Ser Leu Cys His Ala Asn Arg 
            100                 105                 110         


Ser Ala Ala Leu Phe His Leu Gly Gln Tyr Glu Thr Cys Leu Lys Asp 
        115                 120                 125             


Ile Asn Ile Ala Gln Thr His Gly Tyr Pro Glu Arg Leu Gln Pro Lys 
    130                 135                 140                 


Ile Met Leu Arg Lys Ala Glu Cys Leu Val Ala Leu Gly Arg Leu Gln 
145                 150                 155                 160 


Glu Ala Ser Gln Thr Ile Ser Asp Leu Glu Arg Asn Phe Thr Ala Thr 
                165                 170                 175     


Pro Ala Leu Ala Asp Val Leu Pro Gln Thr Leu Gln Arg Asn Leu His 
            180                 185                 190         


Arg Leu Lys Met Lys Met Gln Glu Lys Asp Ser Leu Thr Glu Ser Phe 
        195                 200                 205             


Pro Ala Ala Leu Ala Lys Thr Leu Glu Asp Ala Ala Leu Arg Glu Glu 
    210                 215                 220                 


Asn Glu Gln Leu Ser Asn Ala Ser Ser Ser Ile Gly Leu Cys Val Asp 
225                 230                 235                 240 


Pro Leu Lys Gly Arg Cys Leu Val Ala Thr Lys Asp Ile Leu Pro Gly 
                245                 250                 255     


Glu Leu Leu Val Gln Glu Asp Ala Phe Val Ser Val Leu Asn Pro Gly 
            260                 265                 270         


Glu Leu Pro Pro Pro His His Gly Leu Asp Ser Lys Trp Asp Thr Arg 
        275                 280                 285             


Val Thr Asn Gly Asp Leu Tyr Cys His Arg Cys Leu Lys His Thr Leu 
    290                 295                 300                 


Ala Thr Val Pro Cys Asp Gly Cys Ser Tyr Ala Lys Tyr Cys Ser Gln 
305                 310                 315                 320 


Glu Cys Leu Gln Gln Val Trp Glu Leu Tyr His Arg Thr Glu Cys Pro 
                325                 330                 335     


Leu Gly Gly Leu Leu Leu Thr Leu Gly Val Phe Cys His Ile Ala Leu 
            340                 345                 350         


Arg Leu Thr Leu Leu Val Gly Phe Glu Asp Val Arg Lys Ile Ile Thr 
        355                 360                 365             


Lys Leu Cys Asp Lys Ile Ser Asn Lys Asp Ile Cys Leu Pro Glu Ser 
    370                 375                 380                 


Asn Asn Gln Val Lys Thr Leu Asn Tyr Gly Leu Gly Glu Ser Glu Lys 
385                 390                 395                 400 


Asn Gly Asn Ile Val Glu Thr Pro Ile Pro Gly Cys Asp Ile Asn Gly 
                405                 410                 415     


Lys Tyr Glu Asn Asn Tyr Asn Ala Val Phe Asn Leu Leu Pro His Thr 
            420                 425                 430         


Glu Asn His Ser Pro Glu His Lys Phe Leu Cys Ala Leu Cys Val Ser 
        435                 440                 445             


Ala Leu Cys Arg Gln Leu Glu Ala Ala Ser Leu Gln Ala Ile Pro Thr 
    450                 455                 460                 


Glu Arg Ile Val Asn Ser Ser Gln Leu Lys Ala Ala Val Thr Pro Glu 
465                 470                 475                 480 


Leu Cys Pro Asp Val Thr Ile Trp Gly Val Ala Met Leu Arg His Met 
                485                 490                 495     


Leu Gln Leu Gln Cys Asn Ala Gln Ala Met Thr Thr Ile Gln His Thr 
            500                 505                 510         


Gly Pro Lys Gly Ser Ile Val Thr Asp Ser Arg Gln Val Arg Leu Ala 
        515                 520                 525             


Thr Gly Ile Phe Pro Val Ile Ser Leu Leu Asn His Ser Cys Ser Pro 
    530                 535                 540                 


Asn Thr Ser Val Ser Phe Ile Ser Thr Val Ala Thr Ile Arg Ala Ser 
545                 550                 555                 560 


Gln Arg Ile Arg Lys Gly Gln Glu Ile Leu His Cys Tyr Gly Pro His 
                565                 570                 575     


Lys Ser Arg Met Gly Val Ala Glu Arg Gln Gln Lys Leu Arg Ser Gln 
            580                 585                 590         


Tyr Phe Phe Asp Cys Ala Cys Pro Ala Cys Gln Thr Glu Ala His Arg 
        595                 600                 605             


Met Ala Ala Gly Pro Arg Trp Glu Ala Phe Cys Cys Asn Ser Cys Gly 
    610                 615                 620                 


Ala Pro Met Gln Gly Asp Asp Val Leu Arg Cys Gly Ser Arg Ser Cys 
625                 630                 635                 640 


Ala Glu Ser Ala Val Ser Arg Asp His Leu Val Ser Arg Leu Gln Asp 
                645                 650                 655     


Leu Gln Gln Gln Val Arg Val Ala Gln Lys Leu Leu Arg Asp Gly Glu 
            660                 665                 670         


Leu Glu Arg Ala Val Gln Arg Leu Ser Gly Cys Gln Arg Asp Ala Glu 
        675                 680                 685             


Ser Phe Leu Trp Ala Glu His Ala Val Val Gly Glu Ile Ala Asp Gly 
    690                 695                 700                 


Leu Ala Arg Ala Cys Ala Ala Leu Gly Asp Trp Gln Lys Ser Ala Thr 
705                 710                 715                 720 


His Leu Gln Arg Ser Leu Cys Val Val Glu Val Arg His Gly Pro Ser 
                725                 730                 735     


Ser Val Glu Met Gly His Glu Leu Phe Lys Leu Ala Gln Ile Phe Phe 
            740                 745                 750         


Asn Gly Phe Ala Val Pro Glu Ala Leu Ser Thr Ile Gln Lys Ala Glu 
        755                 760                 765             


Glu Val Leu Ser Leu His Cys Gly Pro Trp Asp Asp Glu Ile Gln Glu 
    770                 775                 780                 


Leu Gln Lys Met Lys Ser Cys Leu Leu Asp Leu Pro Pro Thr Pro Val 
785                 790                 795                 800 


Gly Pro Ala Leu 
                


<210>  3434
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3434
atggctttgg tcacggtcca gcggtcacct acccccagca ccacctccag cccctgcgcc     60

tcggaggcag acagtgggga ggaagaatgc cggtcacagc ccaggagcat cagcgagagc    120

tttctaactg tcaaaggtgc tgcccttttt ctaccacggg gaaatggctc atccacacca    180

agaatcagcc acagacggaa caagcatgca ggcgatctcc aacagcatct ccaagcaatg    240

ttcattttac tccgcccaga agacaacatc agactggctg taagactgga aagtacttac    300

cagaatcgaa cacgctatat ggtagtggtt tcaactaatg gtagacaaga cactgaagaa    360

agcatcgtcc taggaatgga tttctcctct aatgacagta gcacttgtac catgggctta    420

gttttgcctc tctggagcga cacgctaatt catttggatg gtgatggtgg gttcagtgta    480

tcgacggata acagagttca catattcaaa cctgtatctg tgcaggcaat gtggtctgca    540

ctacagagct tacacaaggc ttgtgaagtc gccagagcgc ataactacta cccaggcagc    600

ctatttctca cttgggtgag ttattatgag agccatatca actcagatca atcctcagtc    660

aatgaatgga atgcaatgca agatgtacag tcccaccggc ccgactctcc agctctcttc    720

accgacatac ctactgaacg tgaacgaaca gaaaggctaa ttaaaaccaa attaagggag    780

atcatgatgc agaaggattt ggagaatatt acatccaaag agataagaac agagttggaa    840

atgcaaatgg tgtgcaactt gcgggaattc aaggaattta tagacaatga aatgatagtg    900

atccttggtc aaatggatag ccctacacag atatttgagc atgtgttcct gggctcagaa    960

tggaatgcct ccaacttaga ggacttacag aaccgagggg tacggtatat cttgaatgtc   1020

actcgagaga tagataactt cttcccagga gtctttgagt atcataacat tcgggtatat   1080

gatgaagagg caacggatct cctggcgtac tggaatgaca cttacaaatt catctctaaa   1140

gcaaagaaac atggatctaa atgccttgtg cactgcaaaa tgggggtgag tcgctcagcc   1200

tccaccgtga ttgcctatgc aatgaaggaa tatggctgga atctggaccg agcctatgac   1260

tatgtgaaag aaagacgaac ggtaaccaag cccaacccaa gcttcatgag acaactggaa   1320

gagtatcagg ggatcttgct ggcaagcaaa cagcggcata acaaactatg gagatctcat   1380

tcagatagtg acctctcaga ccaccacgaa cccatctgca aacctgggct agaactcaac   1440

aagaaggata tcaccacctc agcagaccag attgctgagg tgaagaccat ggagagtcac   1500

ccacccatac ctcctgtctt tgtggaacat atggtcccac aagatgcaaa tcagaaaggc   1560

ctgtgtacca aagaaagaat gatctgcttg gagtttactt ctagggaatt tcatgctgga   1620

cagattgagg atgaattaaa cttaaatgac atcaatggat gctcatcagg gtgttgtctg   1680

aatgaatcaa aatttcctct tgacaattgc catgcatcca aagccttaat tcagcctgga   1740

catgtcccag aaatggccaa caagtttcca gacttaacag tggaagattt ggagacagat   1800

gcactgaaag cagacatgaa tgtccaccta ctgcctatgg aagaattgac atctccactg   1860

aaagaccccc ccatgtcccc tgatcctgag tcaccaagcc cccaacccag ttgccagact   1920

gaaatctcag atttcagtac agatcgcatt gactttttta gtgccctaga gaagtttgtg   1980

gagctctccc aagaaacccg gtcacgatct ttttcccatt caaggatgga ggaactgggt   2040

ggaggaagga atgagagctg tcgactgtca gtggtagaag tagccccttc caaagtgaca   2100

gctgatgacc agagaagcag ctctttgagt aatactcccc atgcatcaga agaatcttca   2160

atggatgagg aacagtcaaa ggcaatttca gaactggtca gcccagacat cttcatgcag   2220

tctcactcgg aaaatgcaat ttcagtcaaa gaaattgtca ctgaaattga gtccatcagt   2280

caaggagttg ggcagattca actgaaagga gacatcttac ccaacccatg ccatacacca   2340

aagaagaaca gcatccatga gctgctcctt gagagggccc agactccaga gaacaaacct   2400

ggacatatgg agcaagatga ggactcctgc acagcccagc ctgaactagc caaagactca   2460

gggatgtgca acccagaagg ctgcctaacc acacactcat ctatagcaga cttggaagaa   2520

ggggaaccag ctgaggggga acaagagctc cagggctcag ggatgcaccc aggtgccaag   2580

tggtaccctg ggtctgtgag gcgagccacc ttggagttcg aagagcgctt acggcaggag   2640

caagagcatc atggtgctgc cccaacatgt acctcattgt ccactcgtaa gaattcaaag   2700

aatgattctt ctgtggcaga cctagcacca aaagggaaaa gtgatgaagc ccccccagaa   2760

cattcatttg tcctcaagga accagaaatg agcaaaggca aagggaaata cagtgggtct   2820

gaggctggct cactgtccca ttctgagcag aatgccactg ttccagctcc cagggtgctg   2880

gagtttgacc acttgccaga tcctcaggag ggcccagggt cagatactgg aacacagcag   2940

gaaggagtcc tgaaggatct gaggactgtg attccatacc aggagtctga aacacaagca   3000

gtccctcttc cccttcccaa gagggtagaa atcattgaat atacccacat agttacatca   3060

cccaatcaca ctgggccagg gagtgaaata gccaccagtg agaagagcgg agagcaaggg   3120

ctgaggaaag tgaacatgga aaaatctgtc actgtgctct gcacactgga tgaaaatcta   3180

aacaggactc tggaccccaa ccaggtttct ctgcaccccc aagtgctacc tctgcctcat   3240

tcttcctccc ctgagcacaa cagacccact gaccatccaa cctccatcct gagtagccct   3300

gaagacagag gcagcagcct gtccacagcc ctggagacag cagcaccttt tgtcagtcat   3360

acaacccatt tactgtctgc cagtttggat tacctgcatc cccagactat ggttcacctg   3420

gagggcttca cagagcagag cagcactaca gatgagccct ctgcagaaca ggttagctgg   3480

gaagaaagtc aggagagccc tctctccagt ggcagtgagg tgccatataa ggactcccag   3540

ctaagtagcg cagacctaag tttaattagc aaacttggtg acaacactgg ggagttacag   3600

gagaaaatgg acccattgcc tgtagcctgt cgactcccac atagctctag tagtgaaaac   3660

ataaagagtc tcagccacag ccccggtgtg gtgaaggagc gtgctaaaga aatcgagtct   3720

cgagtggttt tccaggcagg gctcaccaaa ccatcccaaa tgaggcgctc agcttctctc   3780

gccaaattag gttacttgga cctctgtaaa gactgcttac cagagaggga gcctgcctcc   3840

tgtgaatccc ctcatctcaa actgcttcag cctttcctca gaacagactc aggcatgcac   3900

gcgatggagg accaagagtc cctagaaaac ccaggtgccc cccacaaccc agagcccacc   3960

aagtcttttg tagaacaact cacaacaaca gagtgtattg tgcagagcaa gccagtggag   4020

aggccccttg tgcagtatgc caaagaattt ggttctagtc agcagtattt gctccccagg   4080

gcaggacttg aattgactag ttctgaagga ggccttcccg tgctacagac ccagggactg   4140

cagtgtgcat gcccagctcc agggctggcc gtggcacccc gtcagcaaca cggcagaact   4200

caccccctta ggagactgaa aaaggcaaat gacaaaaaac ggacaaccaa ccccttctat   4260

aataccatgt gattctgagc ctacacatgt gactttctag aagaaatgtt tgtaaaaggg   4320

gcaggtgtaa tatgtaagga acatgcactt tattggttaa ttttataata ttttggtcat   4380

tttactgttt ctggtgcatg cagggtttgg gtgtttttca gtgtgtatgt gtgtgtatat   4440

gtaaggggaa agagagattg atctggatgg caagaccgtt tatcattttt tatttaaaaa   4500

aatcaaacct caaaaaagtc attttcagag aacaccttta tcaaaggcaa attgctgttt   4560

ttcagtcagc tgccacctgc ttctcatttt gccctctgag aaaaggcatg gtttcttaat   4620

tgagggaagg aagcagattc ggaggggtgg agataaagct ggggattgga gatgttcccc   4680

tgcctttgtg atgatggttt ggtttccaga cctgaggcat cgaatgggct aaaggtcagc   4740

cagaagtcag agggctctca gccttcatcc agccgcagcc ctttagagtt cctgaaggag   4800

gcaggttccg ctttgcttta aaagagggtc ttccggtgtt ccagagtgta tcgttacagt   4860

aagacatgat aatggccggc tctgcaaatt tatcatatag tttttttccc aagaaaatta   4920

tttttgaaat taaaacagga ccccaaatga aatccaagtg gtcttctgta gaggaaagca   4980

tgataagagg aggaagacat aaagttgggg gtggagaggc tgctgcccag aaactgctgg   5040

gttggtggga tccacacaga tgggcatctt ggctctccct gccagaaaaa tgtgctctgc   5100

agtgtcctcc caactgaaaa caacagtgac atgtttgaaa agcagcaatc gaaagtcagt   5160

gtgttcttgt aaaatgaata tgtatgtagg gttttaaccc ttccattact tgaataattc   5220

tttgggcctt ctgagtttaa tggccatatt ttcttccagt ttattttcct tccccatgct   5280

gttgtcccca tgctgcctat ttttttaaat ttcatagatt atatttgaat tgttacatat   5340

gtttaacatc cattgaatgc aacgttttat ttttggtatt atcactgtta acactttttt   5400

ttccttttcc tggaaggttt gtcatttctc taaagtttgt acacagtatt tatgtacata   5460

atattgtcac tgtcttagtg tcttgttcat gttgtagggt aattttgatt tattcttttt   5520

aagaaggagt agagttgcaa ctggaaaaca cagacaccag aaatgaaagt gttgggtgtt   5580

gataggaatc tgtacaatat gttgatggtg gctgtagttg tttaaatgga gacttccaat   5640

caccagctcc tgccaaatta tgcattagta actttttcct cagagacacc cctaaaggct   5700

cccattaggt cacagcgtga ctgaaagctg atttctctgt gagactgaaa tcccagaaca   5760

ttgtttgcca gtatctcaac cacagccagg aagtatatgt gagttgccca gagtggaagc   5820

tcctagtaga ggctgaaggc cacaggggag gcctcagcca ggggcaagtg cccacagtga   5880

ctccatttag gatgctgtcg ttttgctact gttgtggaga tccttaacgc agcagcgcct   5940

gtcataaaca agcctcttgt agcttcttac agaaaacaga tttagtctag catgaaacac   6000

ctctgcatct cattgaaact gaagaggctt gcagatttgc tttcgttgat gtccacgtta   6060

ctgaggattg actgagtata gactggagac aggtttttgg cttatcacag cactgaggaa   6120

aatacaaatg cacagactgt cagcatgatg tcagaggcca gagtttggtg ggggcagatg   6180

gcagggcgac ccaaaagatg cagaaaaggt agactggggc cactgggtct taagaggagc   6240

tgtgaagttg tgtggaagcc aaggctgggt ctgacatccc tgccaggaag caggttggac   6300

agaaaccact tgctaaaagc gtctctatgg tgcagtgatt atgtgtaccc tgtgctgttg   6360

ctcagtagtc tccttgaatg ttcaagtatc tcatccactc agttttgtga ttcctggata   6420

tttgtgtgtt gtaaagtgtt ttgttaggtg gtatgaacca atgtgaggag gcttgagaca   6480

gggttatgga tttccagagc tcttccatgt agaataccct gccttcttga agcagttcca   6540

ccaccaatat gatggggaag ggcaggaact tatggcaggg tggggagagg gtttgcctgg   6600

aagttaagag agtggcatcc acttgtggta accccttacg atgatgacat cccacacact   6660

aagaggtaca agcaggacca aagttttgga ctgttccctc ttctcccctc cactgtgttt   6720

aatgttcact cactgcatta aataacaaca aagatgggac aaaacccact aatactgtgg   6780

ggaaaaaaaa ttttcaagag cagaggaaag tctttctgcc tttttataat tacttttttt   6840

atcatttaat ttacctgcct aaataaacat cttctacaga atatctgtca ttcaaccatg   6900

ccaaggagtt tgtgccagcc ttttcagact cccagaattg ggtgttcctg ggttatttac   6960

atagctgagc agtgtccagg ggaggtgcgc agtgaactgt caaggacttt ccagactgtc   7020

ttctcttcag acttttataa tctccagtgg catctttccc ttttcttttg ttcatgacct   7080

gacctgaagc agcagatttg atagactggc aaagatgaat aggaaaaact ttgactcttg   7140

cccagtgcct gcctgcctct ctctctctcc tctctctctc tctcttttta aaccaccata   7200

gactctcact tattttggag gagtgtatgt gcatgtgtac acatatgtac atatataaaa   7260

acagttgatg ttttggtgta tggggtaaaa gccccaggag catacagaac ttgagctgaa   7320

cctggtcagt agaaagggaa accccaaccc tttcttgatt tttggagaca cccaggacta   7380

atggatactg tagtagacat gtagtactat agtaccgtaa tattcatctc tcctcatttt   7440

agttgccttt cagattctaa atgtttggga tcattcctat catcttagtc tcttcaggat   7500

ctttagtatt ttcctggttc tgaggaggct tgagacaggg ttatggattt ccttgttctg   7560

tgtctttatc cctactgata gttcctcttt ctcattttgc aaactaccca gagctccaag   7620

gacagcctga agatctcagt gcctcaggct ctgaggtact ctgctcacag gccccagaca   7680

gatgctgttg ggtaaactca aagcttccta tgagaagctt ctgagatgta gcaggtcaca   7740

gaagtgttca cctgtttcat ctgaggattt cagttctgaa gtgatctagg catgtttggt   7800

aaaaatgttt ttgtgagagt tcttttttta agaaagcatt atgcaaaaag tcacttttaa   7860

gggcatttaa aaatttttaa gtaaagccat tctttggctt ttttggacta tttgtggata   7920

ctttgtttac attttgaata ttaaaatgtg catcatcttg tcggccatgc agtcctgcag   7980

gcatcagtgc cctggctgtc ctgtgagtcc tcatgcagag cagggccatc atggtcagcc   8040

cttgtgagta agtgggtata cgctgaagct gacttccgtc tgtgtcctgc cctcccatcc   8100

agcactctct atggaaatag ttgtcatttc ctcagtgatg gtgtgtctta tagtgatggt   8160

tgtaatggtg aatggctagt gtcattttgt tt                                 8192


<210>  3435
<211>  1423
<212>  PRT
<213>  Homosapiens

<400>  3435

Met Ala Leu Val Thr Val Gln Arg Ser Pro Thr Pro Ser Thr Thr Ser 
1               5                   10                  15      


Ser Pro Cys Ala Ser Glu Ala Asp Ser Gly Glu Glu Glu Cys Arg Ser 
            20                  25                  30          


Gln Pro Arg Ser Ile Ser Glu Ser Phe Leu Thr Val Lys Gly Ala Ala 
        35                  40                  45              


Leu Phe Leu Pro Arg Gly Asn Gly Ser Ser Thr Pro Arg Ile Ser His 
    50                  55                  60                  


Arg Arg Asn Lys His Ala Gly Asp Leu Gln Gln His Leu Gln Ala Met 
65                  70                  75                  80  


Phe Ile Leu Leu Arg Pro Glu Asp Asn Ile Arg Leu Ala Val Arg Leu 
                85                  90                  95      


Glu Ser Thr Tyr Gln Asn Arg Thr Arg Tyr Met Val Val Val Ser Thr 
            100                 105                 110         


Asn Gly Arg Gln Asp Thr Glu Glu Ser Ile Val Leu Gly Met Asp Phe 
        115                 120                 125             


Ser Ser Asn Asp Ser Ser Thr Cys Thr Met Gly Leu Val Leu Pro Leu 
    130                 135                 140                 


Trp Ser Asp Thr Leu Ile His Leu Asp Gly Asp Gly Gly Phe Ser Val 
145                 150                 155                 160 


Ser Thr Asp Asn Arg Val His Ile Phe Lys Pro Val Ser Val Gln Ala 
                165                 170                 175     


Met Trp Ser Ala Leu Gln Ser Leu His Lys Ala Cys Glu Val Ala Arg 
            180                 185                 190         


Ala His Asn Tyr Tyr Pro Gly Ser Leu Phe Leu Thr Trp Val Ser Tyr 
        195                 200                 205             


Tyr Glu Ser His Ile Asn Ser Asp Gln Ser Ser Val Asn Glu Trp Asn 
    210                 215                 220                 


Ala Met Gln Asp Val Gln Ser His Arg Pro Asp Ser Pro Ala Leu Phe 
225                 230                 235                 240 


Thr Asp Ile Pro Thr Glu Arg Glu Arg Thr Glu Arg Leu Ile Lys Thr 
                245                 250                 255     


Lys Leu Arg Glu Ile Met Met Gln Lys Asp Leu Glu Asn Ile Thr Ser 
            260                 265                 270         


Lys Glu Ile Arg Thr Glu Leu Glu Met Gln Met Val Cys Asn Leu Arg 
        275                 280                 285             


Glu Phe Lys Glu Phe Ile Asp Asn Glu Met Ile Val Ile Leu Gly Gln 
    290                 295                 300                 


Met Asp Ser Pro Thr Gln Ile Phe Glu His Val Phe Leu Gly Ser Glu 
305                 310                 315                 320 


Trp Asn Ala Ser Asn Leu Glu Asp Leu Gln Asn Arg Gly Val Arg Tyr 
                325                 330                 335     


Ile Leu Asn Val Thr Arg Glu Ile Asp Asn Phe Phe Pro Gly Val Phe 
            340                 345                 350         


Glu Tyr His Asn Ile Arg Val Tyr Asp Glu Glu Ala Thr Asp Leu Leu 
        355                 360                 365             


Ala Tyr Trp Asn Asp Thr Tyr Lys Phe Ile Ser Lys Ala Lys Lys His 
    370                 375                 380                 


Gly Ser Lys Cys Leu Val His Cys Lys Met Gly Val Ser Arg Ser Ala 
385                 390                 395                 400 


Ser Thr Val Ile Ala Tyr Ala Met Lys Glu Tyr Gly Trp Asn Leu Asp 
                405                 410                 415     


Arg Ala Tyr Asp Tyr Val Lys Glu Arg Arg Thr Val Thr Lys Pro Asn 
            420                 425                 430         


Pro Ser Phe Met Arg Gln Leu Glu Glu Tyr Gln Gly Ile Leu Leu Ala 
        435                 440                 445             


Ser Lys Gln Arg His Asn Lys Leu Trp Arg Ser His Ser Asp Ser Asp 
    450                 455                 460                 


Leu Ser Asp His His Glu Pro Ile Cys Lys Pro Gly Leu Glu Leu Asn 
465                 470                 475                 480 


Lys Lys Asp Ile Thr Thr Ser Ala Asp Gln Ile Ala Glu Val Lys Thr 
                485                 490                 495     


Met Glu Ser His Pro Pro Ile Pro Pro Val Phe Val Glu His Met Val 
            500                 505                 510         


Pro Gln Asp Ala Asn Gln Lys Gly Leu Cys Thr Lys Glu Arg Met Ile 
        515                 520                 525             


Cys Leu Glu Phe Thr Ser Arg Glu Phe His Ala Gly Gln Ile Glu Asp 
    530                 535                 540                 


Glu Leu Asn Leu Asn Asp Ile Asn Gly Cys Ser Ser Gly Cys Cys Leu 
545                 550                 555                 560 


Asn Glu Ser Lys Phe Pro Leu Asp Asn Cys His Ala Ser Lys Ala Leu 
                565                 570                 575     


Ile Gln Pro Gly His Val Pro Glu Met Ala Asn Lys Phe Pro Asp Leu 
            580                 585                 590         


Thr Val Glu Asp Leu Glu Thr Asp Ala Leu Lys Ala Asp Met Asn Val 
        595                 600                 605             


His Leu Leu Pro Met Glu Glu Leu Thr Ser Pro Leu Lys Asp Pro Pro 
    610                 615                 620                 


Met Ser Pro Asp Pro Glu Ser Pro Ser Pro Gln Pro Ser Cys Gln Thr 
625                 630                 635                 640 


Glu Ile Ser Asp Phe Ser Thr Asp Arg Ile Asp Phe Phe Ser Ala Leu 
                645                 650                 655     


Glu Lys Phe Val Glu Leu Ser Gln Glu Thr Arg Ser Arg Ser Phe Ser 
            660                 665                 670         


His Ser Arg Met Glu Glu Leu Gly Gly Gly Arg Asn Glu Ser Cys Arg 
        675                 680                 685             


Leu Ser Val Val Glu Val Ala Pro Ser Lys Val Thr Ala Asp Asp Gln 
    690                 695                 700                 


Arg Ser Ser Ser Leu Ser Asn Thr Pro His Ala Ser Glu Glu Ser Ser 
705                 710                 715                 720 


Met Asp Glu Glu Gln Ser Lys Ala Ile Ser Glu Leu Val Ser Pro Asp 
                725                 730                 735     


Ile Phe Met Gln Ser His Ser Glu Asn Ala Ile Ser Val Lys Glu Ile 
            740                 745                 750         


Val Thr Glu Ile Glu Ser Ile Ser Gln Gly Val Gly Gln Ile Gln Leu 
        755                 760                 765             


Lys Gly Asp Ile Leu Pro Asn Pro Cys His Thr Pro Lys Lys Asn Ser 
    770                 775                 780                 


Ile His Glu Leu Leu Leu Glu Arg Ala Gln Thr Pro Glu Asn Lys Pro 
785                 790                 795                 800 


Gly His Met Glu Gln Asp Glu Asp Ser Cys Thr Ala Gln Pro Glu Leu 
                805                 810                 815     


Ala Lys Asp Ser Gly Met Cys Asn Pro Glu Gly Cys Leu Thr Thr His 
            820                 825                 830         


Ser Ser Ile Ala Asp Leu Glu Glu Gly Glu Pro Ala Glu Gly Glu Gln 
        835                 840                 845             


Glu Leu Gln Gly Ser Gly Met His Pro Gly Ala Lys Trp Tyr Pro Gly 
    850                 855                 860                 


Ser Val Arg Arg Ala Thr Leu Glu Phe Glu Glu Arg Leu Arg Gln Glu 
865                 870                 875                 880 


Gln Glu His His Gly Ala Ala Pro Thr Cys Thr Ser Leu Ser Thr Arg 
                885                 890                 895     


Lys Asn Ser Lys Asn Asp Ser Ser Val Ala Asp Leu Ala Pro Lys Gly 
            900                 905                 910         


Lys Ser Asp Glu Ala Pro Pro Glu His Ser Phe Val Leu Lys Glu Pro 
        915                 920                 925             


Glu Met Ser Lys Gly Lys Gly Lys Tyr Ser Gly Ser Glu Ala Gly Ser 
    930                 935                 940                 


Leu Ser His Ser Glu Gln Asn Ala Thr Val Pro Ala Pro Arg Val Leu 
945                 950                 955                 960 


Glu Phe Asp His Leu Pro Asp Pro Gln Glu Gly Pro Gly Ser Asp Thr 
                965                 970                 975     


Gly Thr Gln Gln Glu Gly Val Leu Lys Asp Leu Arg Thr Val Ile Pro 
            980                 985                 990         


Tyr Gln Glu Ser Glu Thr Gln Ala  Val Pro Leu Pro Leu  Pro Lys Arg 
        995                 1000                 1005             


Val Glu  Ile Ile Glu Tyr Thr  His Ile Val Thr Ser  Pro Asn His 
    1010                 1015                 1020             


Thr Gly  Pro Gly Ser Glu Ile  Ala Thr Ser Glu Lys  Ser Gly Glu 
    1025                 1030                 1035             


Gln Gly  Leu Arg Lys Val Asn  Met Glu Lys Ser Val  Thr Val Leu 
    1040                 1045                 1050             


Cys Thr  Leu Asp Glu Asn Leu  Asn Arg Thr Leu Asp  Pro Asn Gln 
    1055                 1060                 1065             


Val Ser  Leu His Pro Gln Val  Leu Pro Leu Pro His  Ser Ser Ser 
    1070                 1075                 1080             


Pro Glu  His Asn Arg Pro Thr  Asp His Pro Thr Ser  Ile Leu Ser 
    1085                 1090                 1095             


Ser Pro  Glu Asp Arg Gly Ser  Ser Leu Ser Thr Ala  Leu Glu Thr 
    1100                 1105                 1110             


Ala Ala  Pro Phe Val Ser His  Thr Thr His Leu Leu  Ser Ala Ser 
    1115                 1120                 1125             


Leu Asp  Tyr Leu His Pro Gln  Thr Met Val His Leu  Glu Gly Phe 
    1130                 1135                 1140             


Thr Glu  Gln Ser Ser Thr Thr  Asp Glu Pro Ser Ala  Glu Gln Val 
    1145                 1150                 1155             


Ser Trp  Glu Glu Ser Gln Glu  Ser Pro Leu Ser Ser  Gly Ser Glu 
    1160                 1165                 1170             


Val Pro  Tyr Lys Asp Ser Gln  Leu Ser Ser Ala Asp  Leu Ser Leu 
    1175                 1180                 1185             


Ile Ser  Lys Leu Gly Asp Asn  Thr Gly Glu Leu Gln  Glu Lys Met 
    1190                 1195                 1200             


Asp Pro  Leu Pro Val Ala Cys  Arg Leu Pro His Ser  Ser Ser Ser 
    1205                 1210                 1215             


Glu Asn  Ile Lys Ser Leu Ser  His Ser Pro Gly Val  Val Lys Glu 
    1220                 1225                 1230             


Arg Ala  Lys Glu Ile Glu Ser  Arg Val Val Phe Gln  Ala Gly Leu 
    1235                 1240                 1245             


Thr Lys  Pro Ser Gln Met Arg  Arg Ser Ala Ser Leu  Ala Lys Leu 
    1250                 1255                 1260             


Gly Tyr  Leu Asp Leu Cys Lys  Asp Cys Leu Pro Glu  Arg Glu Pro 
    1265                 1270                 1275             


Ala Ser  Cys Glu Ser Pro His  Leu Lys Leu Leu Gln  Pro Phe Leu 
    1280                 1285                 1290             


Arg Thr  Asp Ser Gly Met His  Ala Met Glu Asp Gln  Glu Ser Leu 
    1295                 1300                 1305             


Glu Asn  Pro Gly Ala Pro His  Asn Pro Glu Pro Thr  Lys Ser Phe 
    1310                 1315                 1320             


Val Glu  Gln Leu Thr Thr Thr  Glu Cys Ile Val Gln  Ser Lys Pro 
    1325                 1330                 1335             


Val Glu  Arg Pro Leu Val Gln  Tyr Ala Lys Glu Phe  Gly Ser Ser 
    1340                 1345                 1350             


Gln Gln  Tyr Leu Leu Pro Arg  Ala Gly Leu Glu Leu  Thr Ser Ser 
    1355                 1360                 1365             


Glu Gly  Gly Leu Pro Val Leu  Gln Thr Gln Gly Leu  Gln Cys Ala 
    1370                 1375                 1380             


Cys Pro  Ala Pro Gly Leu Ala  Val Ala Pro Arg Gln  Gln His Gly 
    1385                 1390                 1395             


Arg Thr  His Pro Leu Arg Arg  Leu Lys Lys Ala Asn  Asp Lys Lys 
    1400                 1405                 1410             


Arg Thr  Thr Asn Pro Phe Tyr  Asn Thr Met 
    1415                 1420             


<210>  3436
<211>  3960
<212>  DNA
<213>  Homosapiens

<400>  3436
aggagtgagg gagctttttt aacttctgga gtactttgtg atgtttatta atattttctt     60

tctttttgtt attaatactg gtctagtaat attcttctat accatttggt gataactttt    120

ggagtccaaa tgaatgagtc agcatctcaa gaggaactca gacctgctca ggaaaacaga    180

aaagaagaca aagagaggaa atggaactta actgaagtga aagagcttca tgagacctta    240

cagagtgtgc cagacgttcc tgtaaaagag gacaccaaca gtgtggtgga gaaagcaatg    300

gatgaaatca aatcccaaga attaaacctg gaggggcagc gaaaaatttc acctggttca    360

ataaaggact ctaaaactga agcctcaggt aatattgcaa ttagaaaatc tgcaaaagtg    420

atttttgctt tagatgaaac tgaactgaaa tcaaagccag agcacacatg gaagaaaaac    480

ctttttgaaa gaatggaggc aagagcccaa gcaatgcagc agaaaataat agataaggaa    540

aatctgaaga aggaactaga aaaaaaggct gaaaaaaaac tccctaggga taatttggcc    600

aaagagtggt ttaatactga cagcatgaca ctgaataata ctgcatattt gcttgacaaa    660

cttctaccca ccttagttcc tggagtagaa aacatgttaa ctcaagtaga aaagaagaag    720

gttttgacag aagctgatac tccaagcaag tttgacccaa ttaattattt gggggaatat    780

ttaataagaa acaatcctaa ttatatcaaa gacccaggaa tgtctggtta ccagaggttg    840

atgaaagaag tcacagaaga cctgaagata tatgttcctg acactatctg caacagagta    900

tccaagatga aggagaatgt taaacagaat agaaaacaaa gagaaagcat agacaaaatc    960

aaagtcaagg tggccaacac acggaaacag gctctgcagg agcaattcga tgaatggatt   1020

ctagacccta aaggaatgat tcctaagtca gtgattcaga atgttcttca agaattcttt   1080

caaaatccag atttcaagct tggatcacac tgcaaacaac tggatattac tgactcaaca   1140

gaaccaagat tgaacaaaat ggaatttaca gaatacatct cttcacatat taaagacttg   1200

aagagtgaaa tgtttgagga acttcttaag cacctttgcc actctgcaga tgaatttcgg   1260

gaggtcataa aagctgacat gcggaggcag atgttcgctg aactcttcct acattgtgac   1320

cacgggaagg tagggttttt ggatcggcag aggacattgg ccctgctgga attgttctat   1380

gaccatagtt cacaaatgct taggagttta cttcgaaacc cacgacaatg gccattcatt   1440

gaatttgaag agataaactt gactgagttg tggggagaca tggataatca gaaacacatt   1500

tatgaaggtt ttgacaaagt gctcttggag atgaatacat tactttctgc aaatcatgct   1560

agcaaaaccc aaagtaaatt attagaaagt ccagatcaac ctaaacttaa cgaacagaga   1620

acatcaacac catcaccaaa cccgccagaa cagcagagag gagtaactgc agaacaagga   1680

ccacaaagaa tttcaattga agaacaacaa caaggcaaaa agccaactgc agagcaagaa   1740

ctgtacatag aatcagtaat agaaccagga acacacacag agtcaactct agaacaaggg   1800

tcaagtagaa ggttactgac agaacaagaa acacacagag agtcaactac agaacaagga   1860

cagcacaaag ggtcaataga aggacaagga ccacgcagag tgtcagtttc agaacaagga   1920

tcaagcagag agtcagttgc agaacaaggg tcacgcagag agtctattgc agaacaagat   1980

cgacacaaag ggtcagtagc agaacaagga tcacgcagaa tgtcagctgc agaacaggga   2040

tcactcagag agtcagtaat agaagaacca taccaaaaat cagaacaagg accttatgga   2100

gagataattt cagaagagca agaagacata ggctcaactt cacaatcaag aaaagatagt   2160

atcttaaaaa gtacaaaata tggggaacct ataacctctg agtacattga agtccctcta   2220

caggaaaaga ggtcttggga acaaacatat gaagaggaaa tattcctgag ttctgaactg   2280

caagaggaag ttccaacgtt aagcagaaaa gatcactttc cagaaactac aaaaaaggaa   2340

gttcagaaag acaagccctg tgaacccaag tcccaaaaaa tagaaggaaa gtcatggtca   2400

ggtgaatttt ttacttgtaa ctggaaaatg aagtatgtca catttgaaga tgaggaacag   2460

gcaaacttaa tctatggtaa ctccaggttc acagatttac actcaattat cagaaatatt   2520

cagtcttgca aggaggtaaa aggcagaact gccttcaatg gagtttcatt caatctgctc   2580

cagtttgtgc aactcctgga gacatttgtt ggtgaagacg ctcccttgag tgtcagcgag   2640

actctcacct ccttttttaa ggagggctat gttgaaacag aacaagagaa aatgaatgcc   2700

ttagaacagt ttagccaaaa tgctttccaa gtccgacaga ggcttctcct agaagccatc   2760

tttcagaagt gggacagtga tggctcaggc ttcctggatc tgaaggaagt tgatgaactc   2820

ttgtacacat acaaggaggg aatggaaaaa gaatctatga agaaaggtct cactctgtcg   2880

ccaggctgga gtgcagtggc gcaactgtag ctcactgcag cctccaactc ccggactcaa   2940

gcgatcatcc catcacagac tcctgagcaa ctgggactac agggaaagaa ggaagttttt   3000

tcctcttgag accaaatttc cataaaatga gatgcaaaaa ttttaagtgt atatttgctg   3060

agttttgaca aatacatgcc ctatgcatcc catactccta tcaagataca gaacaaagag   3120

cactgtgaca ctcacctgta atcccagcta ctcaagaggc agaggcagga agattgcttg   3180

agcccaggag ttcaagatca gcctgggtaa cattgcaaaa accatctctt aaaaaaaata   3240

aataaaagat atagaacaaa aaaagtcccc acacctcttt cccattcagt cgtccaccct   3300

ccaatcccca aagcaaccac ctttctattt tctaccataa attagtttta tctcttctgg   3360

aatttcataa aaatgaaatt atacagtatg catctttttt tacagagttt aaactctatg   3420

tactcttttt gtaaggcttc tttcactcag cataattttt acttttttaa aaattttttg   3480

ggggagacag agtctcactc tgttgcccaa gctggagtgt agtggcatgt gatcataact   3540

cactgcagcc ttgaactctt gggctcaagc aatcctcccg cctcagcatc ccgagtagct   3600

gggagactac aggtgcacac caccatgcct ggctagttta taaacttttt gtagagacaa   3660

ggtctcacca tgttgcccag gctggccact aactcctggc ctcaagtgat cctccctcct   3720

tagcctccca aagctctgaa ttatattcat aagccactgg gcctggttga ctcagcataa   3780

tttttcttga gagtcttaat atgttgctac atgtatcagc aatttgcttc tttttattgc   3840

tgagtagtat tccattgtat gaatacacca tggtttgttt atccgttttc ctatgtatgg   3900

acacctgggc tgtttccagt tcttagctat tataaataaa gctactctgc acaatcttaa   3960


<210>  3437
<211>  926
<212>  PRT
<213>  Homosapiens

<400>  3437

Met Asn Glu Ser Ala Ser Gln Glu Glu Leu Arg Pro Ala Gln Glu Asn 
1               5                   10                  15      


Arg Lys Glu Asp Lys Glu Arg Lys Trp Asn Leu Thr Glu Val Lys Glu 
            20                  25                  30          


Leu His Glu Thr Leu Gln Ser Val Pro Asp Val Pro Val Lys Glu Asp 
        35                  40                  45              


Thr Asn Ser Val Val Glu Lys Ala Met Asp Glu Ile Lys Ser Gln Glu 
    50                  55                  60                  


Leu Asn Leu Glu Gly Gln Arg Lys Ile Ser Pro Gly Ser Ile Lys Asp 
65                  70                  75                  80  


Ser Lys Thr Glu Ala Ser Gly Asn Ile Ala Ile Arg Lys Ser Ala Lys 
                85                  90                  95      


Val Ile Phe Ala Leu Asp Glu Thr Glu Leu Lys Ser Lys Pro Glu His 
            100                 105                 110         


Thr Trp Lys Lys Asn Leu Phe Glu Arg Met Glu Ala Arg Ala Gln Ala 
        115                 120                 125             


Met Gln Gln Lys Ile Ile Asp Lys Glu Asn Leu Lys Lys Glu Leu Glu 
    130                 135                 140                 


Lys Lys Ala Glu Lys Lys Leu Pro Arg Asp Asn Leu Ala Lys Glu Trp 
145                 150                 155                 160 


Phe Asn Thr Asp Ser Met Thr Leu Asn Asn Thr Ala Tyr Leu Leu Asp 
                165                 170                 175     


Lys Leu Leu Pro Thr Leu Val Pro Gly Val Glu Asn Met Leu Thr Gln 
            180                 185                 190         


Val Glu Lys Lys Lys Val Leu Thr Glu Ala Asp Thr Pro Ser Lys Phe 
        195                 200                 205             


Asp Pro Ile Asn Tyr Leu Gly Glu Tyr Leu Ile Arg Asn Asn Pro Asn 
    210                 215                 220                 


Tyr Ile Lys Asp Pro Gly Met Ser Gly Tyr Gln Arg Leu Met Lys Glu 
225                 230                 235                 240 


Val Thr Glu Asp Leu Lys Ile Tyr Val Pro Asp Thr Ile Cys Asn Arg 
                245                 250                 255     


Val Ser Lys Met Lys Glu Asn Val Lys Gln Asn Arg Lys Gln Arg Glu 
            260                 265                 270         


Ser Ile Asp Lys Ile Lys Val Lys Val Ala Asn Thr Arg Lys Gln Ala 
        275                 280                 285             


Leu Gln Glu Gln Phe Asp Glu Trp Ile Leu Asp Pro Lys Gly Met Ile 
    290                 295                 300                 


Pro Lys Ser Val Ile Gln Asn Val Leu Gln Glu Phe Phe Gln Asn Pro 
305                 310                 315                 320 


Asp Phe Lys Leu Gly Ser His Cys Lys Gln Leu Asp Ile Thr Asp Ser 
                325                 330                 335     


Thr Glu Pro Arg Leu Asn Lys Met Glu Phe Thr Glu Tyr Ile Ser Ser 
            340                 345                 350         


His Ile Lys Asp Leu Lys Ser Glu Met Phe Glu Glu Leu Leu Lys His 
        355                 360                 365             


Leu Cys His Ser Ala Asp Glu Phe Arg Glu Val Ile Lys Ala Asp Met 
    370                 375                 380                 


Arg Arg Gln Met Phe Ala Glu Leu Phe Leu His Cys Asp His Gly Lys 
385                 390                 395                 400 


Val Gly Phe Leu Asp Arg Gln Arg Thr Leu Ala Leu Leu Glu Leu Phe 
                405                 410                 415     


Tyr Asp His Ser Ser Gln Met Leu Arg Ser Leu Leu Arg Asn Pro Arg 
            420                 425                 430         


Gln Trp Pro Phe Ile Glu Phe Glu Glu Ile Asn Leu Thr Glu Leu Trp 
        435                 440                 445             


Gly Asp Met Asp Asn Gln Lys His Ile Tyr Glu Gly Phe Asp Lys Val 
    450                 455                 460                 


Leu Leu Glu Met Asn Thr Leu Leu Ser Ala Asn His Ala Ser Lys Thr 
465                 470                 475                 480 


Gln Ser Lys Leu Leu Glu Ser Pro Asp Gln Pro Lys Leu Asn Glu Gln 
                485                 490                 495     


Arg Thr Ser Thr Pro Ser Pro Asn Pro Pro Glu Gln Gln Arg Gly Val 
            500                 505                 510         


Thr Ala Glu Gln Gly Pro Gln Arg Ile Ser Ile Glu Glu Gln Gln Gln 
        515                 520                 525             


Gly Lys Lys Pro Thr Ala Glu Gln Glu Leu Tyr Ile Glu Ser Val Ile 
    530                 535                 540                 


Glu Pro Gly Thr His Thr Glu Ser Thr Leu Glu Gln Gly Ser Ser Arg 
545                 550                 555                 560 


Arg Leu Leu Thr Glu Gln Glu Thr His Arg Glu Ser Thr Thr Glu Gln 
                565                 570                 575     


Gly Gln His Lys Gly Ser Ile Glu Gly Gln Gly Pro Arg Arg Val Ser 
            580                 585                 590         


Val Ser Glu Gln Gly Ser Ser Arg Glu Ser Val Ala Glu Gln Gly Ser 
        595                 600                 605             


Arg Arg Glu Ser Ile Ala Glu Gln Asp Arg His Lys Gly Ser Val Ala 
    610                 615                 620                 


Glu Gln Gly Ser Arg Arg Met Ser Ala Ala Glu Gln Gly Ser Leu Arg 
625                 630                 635                 640 


Glu Ser Val Ile Glu Glu Pro Tyr Gln Lys Ser Glu Gln Gly Pro Tyr 
                645                 650                 655     


Gly Glu Ile Ile Ser Glu Glu Gln Glu Asp Ile Gly Ser Thr Ser Gln 
            660                 665                 670         


Ser Arg Lys Asp Ser Ile Leu Lys Ser Thr Lys Tyr Gly Glu Pro Ile 
        675                 680                 685             


Thr Ser Glu Tyr Ile Glu Val Pro Leu Gln Glu Lys Arg Ser Trp Glu 
    690                 695                 700                 


Gln Thr Tyr Glu Glu Glu Ile Phe Leu Ser Ser Glu Leu Gln Glu Glu 
705                 710                 715                 720 


Val Pro Thr Leu Ser Arg Lys Asp His Phe Pro Glu Thr Thr Lys Lys 
                725                 730                 735     


Glu Val Gln Lys Asp Lys Pro Cys Glu Pro Lys Ser Gln Lys Ile Glu 
            740                 745                 750         


Gly Lys Ser Trp Ser Gly Glu Phe Phe Thr Cys Asn Trp Lys Met Lys 
        755                 760                 765             


Tyr Val Thr Phe Glu Asp Glu Glu Gln Ala Asn Leu Ile Tyr Gly Asn 
    770                 775                 780                 


Ser Arg Phe Thr Asp Leu His Ser Ile Ile Arg Asn Ile Gln Ser Cys 
785                 790                 795                 800 


Lys Glu Val Lys Gly Arg Thr Ala Phe Asn Gly Val Ser Phe Asn Leu 
                805                 810                 815     


Leu Gln Phe Val Gln Leu Leu Glu Thr Phe Val Gly Glu Asp Ala Pro 
            820                 825                 830         


Leu Ser Val Ser Glu Thr Leu Thr Ser Phe Phe Lys Glu Gly Tyr Val 
        835                 840                 845             


Glu Thr Glu Gln Glu Lys Met Asn Ala Leu Glu Gln Phe Ser Gln Asn 
    850                 855                 860                 


Ala Phe Gln Val Arg Gln Arg Leu Leu Leu Glu Ala Ile Phe Gln Lys 
865                 870                 875                 880 


Trp Asp Ser Asp Gly Ser Gly Phe Leu Asp Leu Lys Glu Val Asp Glu 
                885                 890                 895     


Leu Leu Tyr Thr Tyr Lys Glu Gly Met Glu Lys Glu Ser Met Lys Lys 
            900                 905                 910         


Gly Leu Thr Leu Ser Pro Gly Trp Ser Ala Val Ala Gln Leu 
        915                 920                 925     


<210>  3438
<211>  5084
<212>  DNA
<213>  Homosapiens

<400>  3438
aggagtgagg gagctttttt aacttctgga gtactttgtg atgtttatta atattttctt     60

tctttttgtt attaatactg gtctagtaat attcttctat accatttggt gataactttt    120

ggagtccaaa tgaatgagtc agcatctcaa gaggaactca gacctgctca ggaaaacaga    180

aaagaagaca aagagaggaa atggaactta actgaagtga aagagcttca tgagacctta    240

cagagtgtgc cagacgttcc tgtaaaagag gacaccaaca gtgtggtgga gaaagcaatg    300

gatgaaatca aatcccaaga attaaacctg gaggggcagc gaaaaatttc acctggttca    360

ataaaggact ctaaaactga agcctcaggt aatattgcaa ttagaaaatc tgcaaaagtg    420

atttttgctt tagatgaaac tgaactgaaa tcaaagccag agcacacatg gaagaaaaac    480

ctttttgaaa gaatggaggc aagagcccaa gcaatgcagc agaaaataat agataaggaa    540

aatctgaaga aggaactaga aaaaaaggct gaaaaaaaac tccctaggga taatttggcc    600

aaagagtggt ttaatactga cagcatgaca ctgaataata ctgcatattt gcttgacaaa    660

cttctaccca ccttagttcc tggagtagaa aacatgttaa ctcaagtaga aaagaagaag    720

gttttgacag aagctgatac tccaagcaag tttgacccaa ttaattattt gggggaatat    780

ttaataagaa acaatcctaa ttatatcaaa gacccaggaa tgtctggtta ccagaggttg    840

atgaaagaag tcacagaaga cctgaagata tatgttcctg acactatctg caacagagta    900

tccaagatga aggagaatgt taaacagaat agaaaacaaa gagaaagcat agacaaaatc    960

aaagtcaagg tggccaacac acggaaacag gctctgcagg agcaattcga tgaatggatt   1020

ctagacccta aaggaatgat tcctaagtca gtgattcaga atgttcttca agaattcttt   1080

caaaatccag atttcaagct tggatcacac tgcaaacaac tggatattac tgactcaaca   1140

gaaccaagat tgaacaaaat ggaatttaca gaatacatct cttcacatat taaagacttg   1200

aagagtgaaa tgtttgagga acttcttaag cacctttgcc actctgcaga tgaatttcgg   1260

gaggtcataa aagctgacat gcggaggcag atgttcgctg aactcttcct acattgtgac   1320

cacgggaagg tagggttttt ggatcggcag aggacattgg ccctgctgga attgttctat   1380

gaccatagtt cacaaatgct taggagttta cttcgaaacc cacgacaatg gccattcatt   1440

gaatttgaag agataaactt gactgagttg tggggagaca tggataatca gaaacacatt   1500

tatgaaggtt ttgacaaagt gctcttggag atgaatacat tactttctgc aaatcatgct   1560

agcaaaaccc aaagtaaatt attagaaagt ccagatcaac ctaaacttaa cgaacagaga   1620

acatcaacac catcaccaaa cccgccagaa cagcagagag gagtaactgc agaacaagga   1680

ccacaaagaa tttcaattga agaacaacaa caaggcaaaa agccaactgc agagcaagaa   1740

ctgtacatag aatcagtaat agaaccagga acacacacag agtcaactct agaacaaggg   1800

tcaagtagaa ggttactgac agaacaagaa acacacagag agtcaactac agaacaagga   1860

cagcacaaag ggtcaataga aggacaagga ccacgcagag tgtcagtttc agaacaagga   1920

tcaagcagag agtcagttgc agaacaaggg tcacgcagag agtctattgc agaacaagat   1980

cgacacaaag ggtcagtagc agaacaagga tcacgcagaa tgtcagctgc agaacaggga   2040

tcactcagag agtcagtaat agaagaacca taccaaaaat cagaacaagg accttatgga   2100

gagataattt cagaagagca agaagacata ggctcaactt cacaatcaag aaaagatagt   2160

atcttaaaaa gtacaaaata tggggaacct ataacctctg agtacattga agtccctcta   2220

caggaaaaga ggtcttggga acaaacatat gaagaggaaa tattcctgag ttctgaactg   2280

caagaggaag ttccaacctt aagcagaaaa gatcactttc cagaaactac aaaaaaggaa   2340

gttcagaaag acaagccctg tgaacccaag tcccaaaaaa tagaaggaaa gtcatggtca   2400

ggtgaatttt ttacttgtaa ctggaaaatg aagtatgtca catttgaaga tgaggaacag   2460

gcaaacttaa tctatggtaa ctccaggttc acagatttac actcaattat cagaaatatt   2520

cagtcttgca aggaggtaaa aggcagaact gccttcaatg gagtttcatt caatctgctc   2580

cagtttgtgc aactcctgga gacatttgtt ggtgaagacg ctcccttgag tgtcagcgag   2640

actctcacct ccttttttaa ggagggctat gttgaaacag aacaagagaa aatgaatgcc   2700

ttagaacagt ttagccaaaa tgctttccaa gtccgacaga ggcttctcct agaagccatc   2760

tttcagaagt gggacagtga tggctcaggc ttcctggatc tgaaggaagt tgatgaactc   2820

ttgtacacat acaaggaggg aatggaaaaa gaatctatga agaaagctaa actacacatc   2880

caatttccaa agccacaccc tggtcacgaa gtgagattgt cttcaaaaca atttcagaat   2940

tacatagaat tggttgtgtc tgaactcagg ggcaatgaag accaagttct ggaaagtgtt   3000

gtggaatttc tgatgaatgc tttagagagg agccacattg agagtctgag gaattctgcc   3060

aggcggaaat ggctgcacca aatccaatgt gctgcagaga caagtggggt gtccctagag   3120

ccggtgtata gtgagacctt taaggccctc atgcaggatg ctgaagccca tggaaataaa   3180

aagatcagtg ctcacatttc cctcttagaa gaaaacctac tactgcctga gaaagggaat   3240

gttctattga ggaatgtggc ttgtacctta gatgatgctc aatttgtact gaacagagtg   3300

ctctacaggg acatgaaagg aatcagcttt acagtagtgg atgaagggaa gccaatccat   3360

gttccccaag ttcagtacca tgggaacatc ttcttctgga accagtcccg taataagcat   3420

gattataatg gttcattcct ggctctgcct cttcaagatg catatatgag gatctttggg   3480

gtcttggctg ttgataccct tagagatccc cacgaaataa acatctttct acctcatgag   3540

atcagattct atcagggtgt tgctaatgtc tttagcactg cctatcacta cgtccacagc   3600

cgggagcaca ttctgcatat tgtgatcact ggcataggct ggctttatga cgtcacatcc   3660

agcatcacct ccatcactac gtactttgta gagcctagcc cagcccagga ttcagactat   3720

gttttacgca acatgatggt tacagggcag ctgggtctaa cagaaatcca caaaaatcct   3780

cctaccatcc acaggaagtc atgcatcttc agagatttcc tctttaaatg tactgacagt   3840

tcagaagttg ttctggcttc tgcctgtgga gaaacgcata tagtagttcc acttcgtgag   3900

agaacaggag aggctctggg agtcctcgat tttaacatcg gccaaaatag gatgttgttg   3960

tgtcaagaat ataaagatct acagaaaatg atgaaagtgg tccaagtggc ctgctatgaa   4020

atacttggcg agttctctgg agagataaag aaaaaatata tcttagagat tgaaaatgtc   4080

agggaagtcc agcgggcagg aattctcttc ttccgaatca tgctgctcga gctacaggaa   4140

agcatccaac tactcaattc catggaattt gtgtcactgt tgctctatga ccatactctt   4200

gtaacagagc caaattctcc tcaagacagc aaatctatgg agttggaagc caacgtgaaa   4260

ctagtgcgtg acatcctgaa ggcggttatc ttgttctttc atccagagtt ggaattttca   4320

agtgactttg gaagttggga taagtgtaaa ttttatgtta acaaatattt agtcaacaat   4380

atttgtgcct ttgatccaac tgccaagcat gtggaagtta atgtacagct tattgatgaa   4440

tatatcagag atcattcccg aactgaagta tggaaatttg gtaatgttgt cattgaacat   4500

ctataccact ggatacacat ctgttcagct ctcatgaaga taaccaaaca actaaatagt   4560

ggtattacac ctccgttgcc ctccaagact gacaattata tgtatgcaaa aatgccaggg   4620

gaaggtttgc aagagaagtg ataatggatg ataatggaat tgatactgta tttaggatcc   4680

tttgtttgtt atcagttttg tttgttaact ataaaatatt ttccattgga aaggggtacc   4740

tataaatgtc ttctgctgct aatatttatc tcagcacttt ctaaacccaa aagtgctacc   4800

taagaagaaa tttagccaaa aaatacccag ctaaggtagc catagccaag tgtatttaag   4860

tatgttatag aatatatttg aaagcttcct ttcagtttga gctttgtatc tgctgtggaa   4920

ctgttatggt tgattgggta gttatttttc attcttataa ggttcaaagt aacagctgag   4980

gatttagaaa acaagaatac caaatagaat acgaaataat aaagataaac caaaagaata   5040

ccaaataata aagattttta agaaatggaa aaaaaaaaaa aaaa                    5084


<210>  3439
<211>  1503
<212>  PRT
<213>  Homosapiens

<400>  3439

Met Asn Glu Ser Ala Ser Gln Glu Glu Leu Arg Pro Ala Gln Glu Asn 
1               5                   10                  15      


Arg Lys Glu Asp Lys Glu Arg Lys Trp Asn Leu Thr Glu Val Lys Glu 
            20                  25                  30          


Leu His Glu Thr Leu Gln Ser Val Pro Asp Val Pro Val Lys Glu Asp 
        35                  40                  45              


Thr Asn Ser Val Val Glu Lys Ala Met Asp Glu Ile Lys Ser Gln Glu 
    50                  55                  60                  


Leu Asn Leu Glu Gly Gln Arg Lys Ile Ser Pro Gly Ser Ile Lys Asp 
65                  70                  75                  80  


Ser Lys Thr Glu Ala Ser Gly Asn Ile Ala Ile Arg Lys Ser Ala Lys 
                85                  90                  95      


Val Ile Phe Ala Leu Asp Glu Thr Glu Leu Lys Ser Lys Pro Glu His 
            100                 105                 110         


Thr Trp Lys Lys Asn Leu Phe Glu Arg Met Glu Ala Arg Ala Gln Ala 
        115                 120                 125             


Met Gln Gln Lys Ile Ile Asp Lys Glu Asn Leu Lys Lys Glu Leu Glu 
    130                 135                 140                 


Lys Lys Ala Glu Lys Lys Leu Pro Arg Asp Asn Leu Ala Lys Glu Trp 
145                 150                 155                 160 


Phe Asn Thr Asp Ser Met Thr Leu Asn Asn Thr Ala Tyr Leu Leu Asp 
                165                 170                 175     


Lys Leu Leu Pro Thr Leu Val Pro Gly Val Glu Asn Met Leu Thr Gln 
            180                 185                 190         


Val Glu Lys Lys Lys Val Leu Thr Glu Ala Asp Thr Pro Ser Lys Phe 
        195                 200                 205             


Asp Pro Ile Asn Tyr Leu Gly Glu Tyr Leu Ile Arg Asn Asn Pro Asn 
    210                 215                 220                 


Tyr Ile Lys Asp Pro Gly Met Ser Gly Tyr Gln Arg Leu Met Lys Glu 
225                 230                 235                 240 


Val Thr Glu Asp Leu Lys Ile Tyr Val Pro Asp Thr Ile Cys Asn Arg 
                245                 250                 255     


Val Ser Lys Met Lys Glu Asn Val Lys Gln Asn Arg Lys Gln Arg Glu 
            260                 265                 270         


Ser Ile Asp Lys Ile Lys Val Lys Val Ala Asn Thr Arg Lys Gln Ala 
        275                 280                 285             


Leu Gln Glu Gln Phe Asp Glu Trp Ile Leu Asp Pro Lys Gly Met Ile 
    290                 295                 300                 


Pro Lys Ser Val Ile Gln Asn Val Leu Gln Glu Phe Phe Gln Asn Pro 
305                 310                 315                 320 


Asp Phe Lys Leu Gly Ser His Cys Lys Gln Leu Asp Ile Thr Asp Ser 
                325                 330                 335     


Thr Glu Pro Arg Leu Asn Lys Met Glu Phe Thr Glu Tyr Ile Ser Ser 
            340                 345                 350         


His Ile Lys Asp Leu Lys Ser Glu Met Phe Glu Glu Leu Leu Lys His 
        355                 360                 365             


Leu Cys His Ser Ala Asp Glu Phe Arg Glu Val Ile Lys Ala Asp Met 
    370                 375                 380                 


Arg Arg Gln Met Phe Ala Glu Leu Phe Leu His Cys Asp His Gly Lys 
385                 390                 395                 400 


Val Gly Phe Leu Asp Arg Gln Arg Thr Leu Ala Leu Leu Glu Leu Phe 
                405                 410                 415     


Tyr Asp His Ser Ser Gln Met Leu Arg Ser Leu Leu Arg Asn Pro Arg 
            420                 425                 430         


Gln Trp Pro Phe Ile Glu Phe Glu Glu Ile Asn Leu Thr Glu Leu Trp 
        435                 440                 445             


Gly Asp Met Asp Asn Gln Lys His Ile Tyr Glu Gly Phe Asp Lys Val 
    450                 455                 460                 


Leu Leu Glu Met Asn Thr Leu Leu Ser Ala Asn His Ala Ser Lys Thr 
465                 470                 475                 480 


Gln Ser Lys Leu Leu Glu Ser Pro Asp Gln Pro Lys Leu Asn Glu Gln 
                485                 490                 495     


Arg Thr Ser Thr Pro Ser Pro Asn Pro Pro Glu Gln Gln Arg Gly Val 
            500                 505                 510         


Thr Ala Glu Gln Gly Pro Gln Arg Ile Ser Ile Glu Glu Gln Gln Gln 
        515                 520                 525             


Gly Lys Lys Pro Thr Ala Glu Gln Glu Leu Tyr Ile Glu Ser Val Ile 
    530                 535                 540                 


Glu Pro Gly Thr His Thr Glu Ser Thr Leu Glu Gln Gly Ser Ser Arg 
545                 550                 555                 560 


Arg Leu Leu Thr Glu Gln Glu Thr His Arg Glu Ser Thr Thr Glu Gln 
                565                 570                 575     


Gly Gln His Lys Gly Ser Ile Glu Gly Gln Gly Pro Arg Arg Val Ser 
            580                 585                 590         


Val Ser Glu Gln Gly Ser Ser Arg Glu Ser Val Ala Glu Gln Gly Ser 
        595                 600                 605             


Arg Arg Glu Ser Ile Ala Glu Gln Asp Arg His Lys Gly Ser Val Ala 
    610                 615                 620                 


Glu Gln Gly Ser Arg Arg Met Ser Ala Ala Glu Gln Gly Ser Leu Arg 
625                 630                 635                 640 


Glu Ser Val Ile Glu Glu Pro Tyr Gln Lys Ser Glu Gln Gly Pro Tyr 
                645                 650                 655     


Gly Glu Ile Ile Ser Glu Glu Gln Glu Asp Ile Gly Ser Thr Ser Gln 
            660                 665                 670         


Ser Arg Lys Asp Ser Ile Leu Lys Ser Thr Lys Tyr Gly Glu Pro Ile 
        675                 680                 685             


Thr Ser Glu Tyr Ile Glu Val Pro Leu Gln Glu Lys Arg Ser Trp Glu 
    690                 695                 700                 


Gln Thr Tyr Glu Glu Glu Ile Phe Leu Ser Ser Glu Leu Gln Glu Glu 
705                 710                 715                 720 


Val Pro Thr Leu Ser Arg Lys Asp His Phe Pro Glu Thr Thr Lys Lys 
                725                 730                 735     


Glu Val Gln Lys Asp Lys Pro Cys Glu Pro Lys Ser Gln Lys Ile Glu 
            740                 745                 750         


Gly Lys Ser Trp Ser Gly Glu Phe Phe Thr Cys Asn Trp Lys Met Lys 
        755                 760                 765             


Tyr Val Thr Phe Glu Asp Glu Glu Gln Ala Asn Leu Ile Tyr Gly Asn 
    770                 775                 780                 


Ser Arg Phe Thr Asp Leu His Ser Ile Ile Arg Asn Ile Gln Ser Cys 
785                 790                 795                 800 


Lys Glu Val Lys Gly Arg Thr Ala Phe Asn Gly Val Ser Phe Asn Leu 
                805                 810                 815     


Leu Gln Phe Val Gln Leu Leu Glu Thr Phe Val Gly Glu Asp Ala Pro 
            820                 825                 830         


Leu Ser Val Ser Glu Thr Leu Thr Ser Phe Phe Lys Glu Gly Tyr Val 
        835                 840                 845             


Glu Thr Glu Gln Glu Lys Met Asn Ala Leu Glu Gln Phe Ser Gln Asn 
    850                 855                 860                 


Ala Phe Gln Val Arg Gln Arg Leu Leu Leu Glu Ala Ile Phe Gln Lys 
865                 870                 875                 880 


Trp Asp Ser Asp Gly Ser Gly Phe Leu Asp Leu Lys Glu Val Asp Glu 
                885                 890                 895     


Leu Leu Tyr Thr Tyr Lys Glu Gly Met Glu Lys Glu Ser Met Lys Lys 
            900                 905                 910         


Ala Lys Leu His Ile Gln Phe Pro Lys Pro His Pro Gly His Glu Val 
        915                 920                 925             


Arg Leu Ser Ser Lys Gln Phe Gln Asn Tyr Ile Glu Leu Val Val Ser 
    930                 935                 940                 


Glu Leu Arg Gly Asn Glu Asp Gln Val Leu Glu Ser Val Val Glu Phe 
945                 950                 955                 960 


Leu Met Asn Ala Leu Glu Arg Ser His Ile Glu Ser Leu Arg Asn Ser 
                965                 970                 975     


Ala Arg Arg Lys Trp Leu His Gln Ile Gln Cys Ala Ala Glu Thr Ser 
            980                 985                 990         


Gly Val Ser Leu Glu Pro Val Tyr  Ser Glu Thr Phe Lys  Ala Leu Met 
        995                 1000                 1005             


Gln Asp  Ala Glu Ala His Gly  Asn Lys Lys Ile Ser  Ala His Ile 
    1010                 1015                 1020             


Ser Leu  Leu Glu Glu Asn Leu  Leu Leu Pro Glu Lys  Gly Asn Val 
    1025                 1030                 1035             


Leu Leu  Arg Asn Val Ala Cys  Thr Leu Asp Asp Ala  Gln Phe Val 
    1040                 1045                 1050             


Leu Asn  Arg Val Leu Tyr Arg  Asp Met Lys Gly Ile  Ser Phe Thr 
    1055                 1060                 1065             


Val Val  Asp Glu Gly Lys Pro  Ile His Val Pro Gln  Val Gln Tyr 
    1070                 1075                 1080             


His Gly  Asn Ile Phe Phe Trp  Asn Gln Ser Arg Asn  Lys His Asp 
    1085                 1090                 1095             


Tyr Asn  Gly Ser Phe Leu Ala  Leu Pro Leu Gln Asp  Ala Tyr Met 
    1100                 1105                 1110             


Arg Ile  Phe Gly Val Leu Ala  Val Asp Thr Leu Arg  Asp Pro His 
    1115                 1120                 1125             


Glu Ile  Asn Ile Phe Leu Pro  His Glu Ile Arg Phe  Tyr Gln Gly 
    1130                 1135                 1140             


Val Ala  Asn Val Phe Ser Thr  Ala Tyr His Tyr Val  His Ser Arg 
    1145                 1150                 1155             


Glu His  Ile Leu His Ile Val  Ile Thr Gly Ile Gly  Trp Leu Tyr 
    1160                 1165                 1170             


Asp Val  Thr Ser Ser Ile Thr  Ser Ile Thr Thr Tyr  Phe Val Glu 
    1175                 1180                 1185             


Pro Ser  Pro Ala Gln Asp Ser  Asp Tyr Val Leu Arg  Asn Met Met 
    1190                 1195                 1200             


Val Thr  Gly Gln Leu Gly Leu  Thr Glu Ile His Lys  Asn Pro Pro 
    1205                 1210                 1215             


Thr Ile  His Arg Lys Ser Cys  Ile Phe Arg Asp Phe  Leu Phe Lys 
    1220                 1225                 1230             


Cys Thr  Asp Ser Ser Glu Val  Val Leu Ala Ser Ala  Cys Gly Glu 
    1235                 1240                 1245             


Thr His  Ile Val Val Pro Leu  Arg Glu Arg Thr Gly  Glu Ala Leu 
    1250                 1255                 1260             


Gly Val  Leu Asp Phe Asn Ile  Gly Gln Asn Arg Met  Leu Leu Cys 
    1265                 1270                 1275             


Gln Glu  Tyr Lys Asp Leu Gln  Lys Met Met Lys Val  Val Gln Val 
    1280                 1285                 1290             


Ala Cys  Tyr Glu Ile Leu Gly  Glu Phe Ser Gly Glu  Ile Lys Lys 
    1295                 1300                 1305             


Lys Tyr  Ile Leu Glu Ile Glu  Asn Val Arg Glu Val  Gln Arg Ala 
    1310                 1315                 1320             


Gly Ile  Leu Phe Phe Arg Ile  Met Leu Leu Glu Leu  Gln Glu Ser 
    1325                 1330                 1335             


Ile Gln  Leu Leu Asn Ser Met  Glu Phe Val Ser Leu  Leu Leu Tyr 
    1340                 1345                 1350             


Asp His  Thr Leu Val Thr Glu  Pro Asn Ser Pro Gln  Asp Ser Lys 
    1355                 1360                 1365             


Ser Met  Glu Leu Glu Ala Asn  Val Lys Leu Val Arg  Asp Ile Leu 
    1370                 1375                 1380             


Lys Ala  Val Ile Leu Phe Phe  His Pro Glu Leu Glu  Phe Ser Ser 
    1385                 1390                 1395             


Asp Phe  Gly Ser Trp Asp Lys  Cys Lys Phe Tyr Val  Asn Lys Tyr 
    1400                 1405                 1410             


Leu Val  Asn Asn Ile Cys Ala  Phe Asp Pro Thr Ala  Lys His Val 
    1415                 1420                 1425             


Glu Val  Asn Val Gln Leu Ile  Asp Glu Tyr Ile Arg  Asp His Ser 
    1430                 1435                 1440             


Arg Thr  Glu Val Trp Lys Phe  Gly Asn Val Val Ile  Glu His Leu 
    1445                 1450                 1455             


Tyr His  Trp Ile His Ile Cys  Ser Ala Leu Met Lys  Ile Thr Lys 
    1460                 1465                 1470             


Gln Leu  Asn Ser Gly Ile Thr  Pro Pro Leu Pro Ser  Lys Thr Asp 
    1475                 1480                 1485             


Asn Tyr  Met Tyr Ala Lys Met  Pro Gly Glu Gly Leu  Gln Glu Lys 
    1490                 1495                 1500             


<210>  3440
<211>  4450
<212>  DNA
<213>  Homosapiens

<400>  3440
agccgatggg ggcggggaaa agtccggctg ggccgggaca aaagccggat cccgggaagc     60

taccggctgc tggggtgctc cggattttgc ggggttcgtc gggcctgtgg aagaagcgcc    120

gcgcacggac ttcggcagag gtagagcagg tctctctgca gccatgtcgg ccaaggcaat    180

ttcagagcag acgggcaaag aactccttta caagttcatc tgtaccacct cagccatcca    240

gaatcggttc aagtatgctc gggtcactcc tgacacagac tgggcccgct tgctgcagga    300

ccacccctgg ctgctcagcc agaacttggt agtcaagcca gaccagctga tcaaacgtcg    360

tggaaaactt ggtctcgttg gggtcaacct cactctggat ggggtcaagt cctggctgaa    420

gccacggctg ggacaggaag ccacagttgg caaggccaca ggcttcctca agaactttct    480

gatcgagccc ttcgtccccc acagtcaggc tgaggagttc tatgtctgca tctatgccac    540

ccgagaaggg gactacgtcc tgttccacca cgaggggggt gtggacgtgg gtgatgtgga    600

cgccaaggcc cagaagctgc ttgttggcgt ggatgagaaa ctgaatcctg aggacatcaa    660

aaaacacctg ttggtccacg cccctgaaga caagaaagaa attctggcca gttttatctc    720

cggcctcttc aatttctacg aggacttgta cttcacctac ctcgagatca atccccttgt    780

agtgaccaaa gatggagtct atgtccttga cttggcggcc aaggtggacg ccactgccga    840

ctacatctgc aaagtgaagt ggggtgacat cgagttccct ccccccttcg ggcgggaggc    900

atatccagag gaagcctaca ttgcagacct cgatgccaaa agtggggcaa gcctgaagct    960

gaccttgctg aaccccaaag ggaggatctg gaccatggtg gccgggggtg gcgcctctgt   1020

cgtgtacagc gataccatct gtgatctagg gggtgtcaac gagctggcaa actatgggga   1080

gtactcaggc gcccccagcg agcagcagac ctatgactat gccaagacta tcctctccct   1140

catgacccga gagaagcacc cagatggcaa gatcctcatc attggaggca gcatcgcaaa   1200

cttcaccaac gtggctgcca cgttcaaggg catcgtgaga gcaattcgag attaccaggg   1260

ccccctgaag gagcacgaag tcacaatctt tgtccgaaga ggtggcccca actatcagga   1320

gggcttacgg gtgatgggag aagtcgggaa gaccactggg atccccatcc atgtctttgg   1380

cacagagact cacatgacgg ccattgtggg catggccctg ggccaccggc ccatccccaa   1440

ccagccaccc acagcggccc acactgcaaa cttcctcctc aacgccagcg ggagcacatc   1500

gacgccagcc cccagcagga cagcatcttt ttctgagtcc agggccgatg aggtggcgcc   1560

tgcaaagaag gccaagcctg ccatgccaca agattcagtc ccaagtccaa gatccctgca   1620

aggaaagagc accaccctct tcagccgcca caccaaggcc attgtgtggg gcatgcagac   1680

ccgggccgtg caaggcatgc tggactttga ctatgtctgc tcccgagacg agccctcagt   1740

ggctgccatg gtctaccctt tcactgggga ccacaagcag aagttttact gggggcacaa   1800

agagatcctg atccctgtct tcaagaacat ggctgatgcc atgaggaagc atccggaggt   1860

agatgtgctc atcaactttg cctctctccg ctctgcctat gacagcacca tggagaccat   1920

gaactatgcc cagatccgga ccatcgccat catagctgaa ggcatccctg aggccctcac   1980

gagaaagctg atcaagaagg cggaccagaa gggagtgacc atcatcggac ctgccactgt   2040

tggaggcatc aagcctgggt gctttaagat tggcaacaca ggtgggatgc tggacaacat   2100

cctggcctcc aaactgtacc gcccaggcag cgtggcctat gtctcacgtt ccggaggcat   2160

gtccaacgag ctcaacaata tcatctctcg gaccacggat ggcgtctatg agggcgtggc   2220

cattggtggg gacaggtacc cgggctccac attcatggat catgtgttac gctatcagga   2280

cactccagga gtcaaaatga ttgtggttct tggagagatt gggggcactg aggaatataa   2340

gatttgccgg ggcatcaagg agggccgcct cactaagccc atcgtctgct ggtgcatcgg   2400

gacgtgtgcc accatgttct cctctgaggt ccagtttggc catgctggag cttgtgccaa   2460

ccaggcttct gaaactgcag tagccaagaa ccaggctttg aaggaagcag gagtgtttgt   2520

gccccggagc tttgatgagc ttggagagat catccagtct gtatacgaag atctcgtggc   2580

caatggagtc attgtacctg cccaggaggt gccgccccca accgtgccca tggactactc   2640

ctgggccagg gagcttggtt tgatccgcaa acctgcctcg ttcatgacca gcatctgcga   2700

tgagcgagga caggagctca tctacgcggg catgcccatc actgaggtct tcaaggaaga   2760

gatgggcatt ggcggggtcc tcggcctcct ctggttccag aaaaggttgc ctaagtactc   2820

ttgccagttc attgagatgt gtctgatggt gacagctgat cacgggccag ccgtctctgg   2880

agcccacaac accatcattt gtgcgcgagc tgggaaagac ctggtctcca gcctcacctc   2940

ggggctgctc accatcgggg atcggtttgg gggtgccttg gatgcagcag ccaagatgtt   3000

cagtaaagcc tttgacagtg gcattatccc catggagttt gtgaacaaga tgaagaagga   3060

agggaagctg atcatgggca ttggtcaccg agtgaagtcg ataaacaacc cagacatgcg   3120

agtgcagatc ctcaaagatt acgtcaggca gcacttccct gccactcctc tgctcgatta   3180

tgcactggaa gtagagaaga ttaccacctc gaagaagcca aatcttatcc tgaatgtaga   3240

tggtctcatc ggagtcgcat ttgtagacat gcttagaaac tgtgggtcct ttactcggga   3300

ggaagctgat gaatatattg acattggagc cctcaatggc atctttgtgc tgggaaggag   3360

tatggggttc attggacact atcttgatca gaagaggctg aagcaggggc tgtatcgtca   3420

tccgtgggat gatatttcat atgttcttcc ggaacacatg agcatgtaac agagccagga   3480

accctactgc agtaaactga agacaagatc tcttccccca agaaaaagtg tacagacagc   3540

tggcagtgga gcctgcttta tttagcaggg gcctggaatg taaacagcca ctggggtaca   3600

ggcaccgaag accaacatcc acaggctaac accccttcag tccacacaaa gaagcttcat   3660

atttttttta taagcataga aataaaaacc aagccaatat ttgtgacttt gctctgctac   3720

ctgctgtatt tattatatgg aagcatctaa gtactgtcag gatggggtct tcctcattgt   3780

agggcgttag gatgttgctt tctttttcca ttagttaaac atttttttct cctttggagg   3840

aagggaatga aacatttatg gcctcaagat actatacatt taaagcaccc caatgtctct   3900

cttttttttt ttttacttcc ctttcttctt ccttatataa catgaagaac attgtattaa   3960

tctgattttt aaagatcttt ttgtatgtta cgtgttaagg gcttgtttgg tatcccactg   4020

aaatgttctg tgttgcagac cagagtctgt ttatgtcagg gggatggggc cattgcatcc   4080

ttagccattg tcacaaaata tgtggagtag taacttaata tgtaaagttg taacatacat   4140

acatttaaaa tggaaatgca gaaagctgtg aaatgtcttg tgtcttatgt tctctgtatt   4200

tatgcagctg atttgtctgt ctgtaactga agtgtgggtc caaggactcc taactacttt   4260

gcatctgtaa tccacaaaga ttctgggcag ctgccacctc agtctcttct ctgtattatc   4320

atagtctggt ttaaataaac tatatagtaa caaaaaaaaa aaaaaaaaaa aaaaaaaaaa   4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   4440

aaaaaaaaaa                                                          4450


<210>  3441
<211>  1101
<212>  PRT
<213>  Homosapiens

<400>  3441

Met Ser Ala Lys Ala Ile Ser Glu Gln Thr Gly Lys Glu Leu Leu Tyr 
1               5                   10                  15      


Lys Phe Ile Cys Thr Thr Ser Ala Ile Gln Asn Arg Phe Lys Tyr Ala 
            20                  25                  30          


Arg Val Thr Pro Asp Thr Asp Trp Ala Arg Leu Leu Gln Asp His Pro 
        35                  40                  45              


Trp Leu Leu Ser Gln Asn Leu Val Val Lys Pro Asp Gln Leu Ile Lys 
    50                  55                  60                  


Arg Arg Gly Lys Leu Gly Leu Val Gly Val Asn Leu Thr Leu Asp Gly 
65                  70                  75                  80  


Val Lys Ser Trp Leu Lys Pro Arg Leu Gly Gln Glu Ala Thr Val Gly 
                85                  90                  95      


Lys Ala Thr Gly Phe Leu Lys Asn Phe Leu Ile Glu Pro Phe Val Pro 
            100                 105                 110         


His Ser Gln Ala Glu Glu Phe Tyr Val Cys Ile Tyr Ala Thr Arg Glu 
        115                 120                 125             


Gly Asp Tyr Val Leu Phe His His Glu Gly Gly Val Asp Val Gly Asp 
    130                 135                 140                 


Val Asp Ala Lys Ala Gln Lys Leu Leu Val Gly Val Asp Glu Lys Leu 
145                 150                 155                 160 


Asn Pro Glu Asp Ile Lys Lys His Leu Leu Val His Ala Pro Glu Asp 
                165                 170                 175     


Lys Lys Glu Ile Leu Ala Ser Phe Ile Ser Gly Leu Phe Asn Phe Tyr 
            180                 185                 190         


Glu Asp Leu Tyr Phe Thr Tyr Leu Glu Ile Asn Pro Leu Val Val Thr 
        195                 200                 205             


Lys Asp Gly Val Tyr Val Leu Asp Leu Ala Ala Lys Val Asp Ala Thr 
    210                 215                 220                 


Ala Asp Tyr Ile Cys Lys Val Lys Trp Gly Asp Ile Glu Phe Pro Pro 
225                 230                 235                 240 


Pro Phe Gly Arg Glu Ala Tyr Pro Glu Glu Ala Tyr Ile Ala Asp Leu 
                245                 250                 255     


Asp Ala Lys Ser Gly Ala Ser Leu Lys Leu Thr Leu Leu Asn Pro Lys 
            260                 265                 270         


Gly Arg Ile Trp Thr Met Val Ala Gly Gly Gly Ala Ser Val Val Tyr 
        275                 280                 285             


Ser Asp Thr Ile Cys Asp Leu Gly Gly Val Asn Glu Leu Ala Asn Tyr 
    290                 295                 300                 


Gly Glu Tyr Ser Gly Ala Pro Ser Glu Gln Gln Thr Tyr Asp Tyr Ala 
305                 310                 315                 320 


Lys Thr Ile Leu Ser Leu Met Thr Arg Glu Lys His Pro Asp Gly Lys 
                325                 330                 335     


Ile Leu Ile Ile Gly Gly Ser Ile Ala Asn Phe Thr Asn Val Ala Ala 
            340                 345                 350         


Thr Phe Lys Gly Ile Val Arg Ala Ile Arg Asp Tyr Gln Gly Pro Leu 
        355                 360                 365             


Lys Glu His Glu Val Thr Ile Phe Val Arg Arg Gly Gly Pro Asn Tyr 
    370                 375                 380                 


Gln Glu Gly Leu Arg Val Met Gly Glu Val Gly Lys Thr Thr Gly Ile 
385                 390                 395                 400 


Pro Ile His Val Phe Gly Thr Glu Thr His Met Thr Ala Ile Val Gly 
                405                 410                 415     


Met Ala Leu Gly His Arg Pro Ile Pro Asn Gln Pro Pro Thr Ala Ala 
            420                 425                 430         


His Thr Ala Asn Phe Leu Leu Asn Ala Ser Gly Ser Thr Ser Thr Pro 
        435                 440                 445             


Ala Pro Ser Arg Thr Ala Ser Phe Ser Glu Ser Arg Ala Asp Glu Val 
    450                 455                 460                 


Ala Pro Ala Lys Lys Ala Lys Pro Ala Met Pro Gln Asp Ser Val Pro 
465                 470                 475                 480 


Ser Pro Arg Ser Leu Gln Gly Lys Ser Thr Thr Leu Phe Ser Arg His 
                485                 490                 495     


Thr Lys Ala Ile Val Trp Gly Met Gln Thr Arg Ala Val Gln Gly Met 
            500                 505                 510         


Leu Asp Phe Asp Tyr Val Cys Ser Arg Asp Glu Pro Ser Val Ala Ala 
        515                 520                 525             


Met Val Tyr Pro Phe Thr Gly Asp His Lys Gln Lys Phe Tyr Trp Gly 
    530                 535                 540                 


His Lys Glu Ile Leu Ile Pro Val Phe Lys Asn Met Ala Asp Ala Met 
545                 550                 555                 560 


Arg Lys His Pro Glu Val Asp Val Leu Ile Asn Phe Ala Ser Leu Arg 
                565                 570                 575     


Ser Ala Tyr Asp Ser Thr Met Glu Thr Met Asn Tyr Ala Gln Ile Arg 
            580                 585                 590         


Thr Ile Ala Ile Ile Ala Glu Gly Ile Pro Glu Ala Leu Thr Arg Lys 
        595                 600                 605             


Leu Ile Lys Lys Ala Asp Gln Lys Gly Val Thr Ile Ile Gly Pro Ala 
    610                 615                 620                 


Thr Val Gly Gly Ile Lys Pro Gly Cys Phe Lys Ile Gly Asn Thr Gly 
625                 630                 635                 640 


Gly Met Leu Asp Asn Ile Leu Ala Ser Lys Leu Tyr Arg Pro Gly Ser 
                645                 650                 655     


Val Ala Tyr Val Ser Arg Ser Gly Gly Met Ser Asn Glu Leu Asn Asn 
            660                 665                 670         


Ile Ile Ser Arg Thr Thr Asp Gly Val Tyr Glu Gly Val Ala Ile Gly 
        675                 680                 685             


Gly Asp Arg Tyr Pro Gly Ser Thr Phe Met Asp His Val Leu Arg Tyr 
    690                 695                 700                 


Gln Asp Thr Pro Gly Val Lys Met Ile Val Val Leu Gly Glu Ile Gly 
705                 710                 715                 720 


Gly Thr Glu Glu Tyr Lys Ile Cys Arg Gly Ile Lys Glu Gly Arg Leu 
                725                 730                 735     


Thr Lys Pro Ile Val Cys Trp Cys Ile Gly Thr Cys Ala Thr Met Phe 
            740                 745                 750         


Ser Ser Glu Val Gln Phe Gly His Ala Gly Ala Cys Ala Asn Gln Ala 
        755                 760                 765             


Ser Glu Thr Ala Val Ala Lys Asn Gln Ala Leu Lys Glu Ala Gly Val 
    770                 775                 780                 


Phe Val Pro Arg Ser Phe Asp Glu Leu Gly Glu Ile Ile Gln Ser Val 
785                 790                 795                 800 


Tyr Glu Asp Leu Val Ala Asn Gly Val Ile Val Pro Ala Gln Glu Val 
                805                 810                 815     


Pro Pro Pro Thr Val Pro Met Asp Tyr Ser Trp Ala Arg Glu Leu Gly 
            820                 825                 830         


Leu Ile Arg Lys Pro Ala Ser Phe Met Thr Ser Ile Cys Asp Glu Arg 
        835                 840                 845             


Gly Gln Glu Leu Ile Tyr Ala Gly Met Pro Ile Thr Glu Val Phe Lys 
    850                 855                 860                 


Glu Glu Met Gly Ile Gly Gly Val Leu Gly Leu Leu Trp Phe Gln Lys 
865                 870                 875                 880 


Arg Leu Pro Lys Tyr Ser Cys Gln Phe Ile Glu Met Cys Leu Met Val 
                885                 890                 895     


Thr Ala Asp His Gly Pro Ala Val Ser Gly Ala His Asn Thr Ile Ile 
            900                 905                 910         


Cys Ala Arg Ala Gly Lys Asp Leu Val Ser Ser Leu Thr Ser Gly Leu 
        915                 920                 925             


Leu Thr Ile Gly Asp Arg Phe Gly Gly Ala Leu Asp Ala Ala Ala Lys 
    930                 935                 940                 


Met Phe Ser Lys Ala Phe Asp Ser Gly Ile Ile Pro Met Glu Phe Val 
945                 950                 955                 960 


Asn Lys Met Lys Lys Glu Gly Lys Leu Ile Met Gly Ile Gly His Arg 
                965                 970                 975     


Val Lys Ser Ile Asn Asn Pro Asp Met Arg Val Gln Ile Leu Lys Asp 
            980                 985                 990         


Tyr Val Arg Gln His Phe Pro Ala  Thr Pro Leu Leu Asp  Tyr Ala Leu 
        995                 1000                 1005             


Glu Val  Glu Lys Ile Thr Thr  Ser Lys Lys Pro Asn  Leu Ile Leu 
    1010                 1015                 1020             


Asn Val  Asp Gly Leu Ile Gly  Val Ala Phe Val Asp  Met Leu Arg 
    1025                 1030                 1035             


Asn Cys  Gly Ser Phe Thr Arg  Glu Glu Ala Asp Glu  Tyr Ile Asp 
    1040                 1045                 1050             


Ile Gly  Ala Leu Asn Gly Ile  Phe Val Leu Gly Arg  Ser Met Gly 
    1055                 1060                 1065             


Phe Ile  Gly His Tyr Leu Asp  Gln Lys Arg Leu Lys  Gln Gly Leu 
    1070                 1075                 1080             


Tyr Arg  His Pro Trp Asp Asp  Ile Ser Tyr Val Leu  Pro Glu His 
    1085                 1090                 1095             


Met Ser  Met 
    1100     


<210>  3442
<211>  4420
<212>  DNA
<213>  Homosapiens

<400>  3442
agccgatggg ggcggggaaa agtccggctg ggccgggaca aaagccggat cccgggaagc     60

taccggctgc tggggtgctc cggattttgc ggggttcgtc gggcctgtgg aagaagcgcc    120

gcgcacggac ttcggcagag gtagagcagg tctctctgca gccatgtcgg ccaaggcaat    180

ttcagagcag acgggcaaag aactccttta caagttcatc tgtaccacct cagccatcca    240

gaatcggttc aagtatgctc gggtcactcc tgacacagac tgggcccgct tgctgcagga    300

ccacccctgg ctgctcagcc agaacttggt agtcaagcca gaccagctga tcaaacgtcg    360

tggaaaactt ggtctcgttg gggtcaacct cactctggat ggggtcaagt cctggctgaa    420

gccacggctg ggacaggaag ccacagttgg caaggccaca ggcttcctca agaactttct    480

gatcgagccc ttcgtccccc acagtcaggc tgaggagttc tatgtctgca tctatgccac    540

ccgagaaggg gactacgtcc tgttccacca cgaggggggt gtggacgtgg gtgatgtgga    600

cgccaaggcc cagaagctgc ttgttggcgt ggatgagaaa ctgaatcctg aggacatcaa    660

aaaacacctg ttggtccacg cccctgaaga caagaaagaa attctggcca gttttatctc    720

cggcctcttc aatttctacg aggacttgta cttcacctac ctcgagatca atccccttgt    780

agtgaccaaa gatggagtct atgtccttga cttggcggcc aaggtggacg ccactgccga    840

ctacatctgc aaagtgaagt ggggtgacat cgagttccct ccccccttcg ggcgggaggc    900

atatccagag gaagcctaca ttgcagacct cgatgccaaa agtggggcaa gcctgaagct    960

gaccttgctg aaccccaaag ggaggatctg gaccatggtg gccgggggtg gcgcctctgt   1020

cgtgtacagc gataccatct gtgatctagg gggtgtcaac gagctggcaa actatgggga   1080

gtactcaggc gcccccagcg agcagcagac ctatgactat gccaagacta tcctctccct   1140

catgacccga gagaagcacc cagatggcaa gatcctcatc attggaggca gcatcgcaaa   1200

cttcaccaac gtggctgcca cgttcaaggg catcgtgaga gcaattcgag attaccaggg   1260

ccccctgaag gagcacgaag tcacaatctt tgtccgaaga ggtggcccca actatcagga   1320

gggcttacgg gtgatgggag aagtcgggaa gaccactggg atccccatcc atgtctttgg   1380

cacagagact cacatgacgg ccattgtggg catggccctg ggccaccggc ccatccccaa   1440

ccagccaccc acagcggccc acactgcaaa cttcctcctc aacgccagcg ggagcacatc   1500

gacgccagcc cccagcagga cagcatcttt ttctgagtcc agggccgatg aggtggcgcc   1560

tgcaaagaag gccaagcctg ccatgccaca aggaaagagc accaccctct tcagccgcca   1620

caccaaggcc attgtgtggg gcatgcagac ccgggccgtg caaggcatgc tggactttga   1680

ctatgtctgc tcccgagacg agccctcagt ggctgccatg gtctaccctt tcactgggga   1740

ccacaagcag aagttttact gggggcacaa agagatcctg atccctgtct tcaagaacat   1800

ggctgatgcc atgaggaagc atccggaggt agatgtgctc atcaactttg cctctctccg   1860

ctctgcctat gacagcacca tggagaccat gaactatgcc cagatccgga ccatcgccat   1920

catagctgaa ggcatccctg aggccctcac gagaaagctg atcaagaagg cggaccagaa   1980

gggagtgacc atcatcggac ctgccactgt tggaggcatc aagcctgggt gctttaagat   2040

tggcaacaca ggtgggatgc tggacaacat cctggcctcc aaactgtacc gcccaggcag   2100

cgtggcctat gtctcacgtt ccggaggcat gtccaacgag ctcaacaata tcatctctcg   2160

gaccacggat ggcgtctatg agggcgtggc cattggtggg gacaggtacc cgggctccac   2220

attcatggat catgtgttac gctatcagga cactccagga gtcaaaatga ttgtggttct   2280

tggagagatt gggggcactg aggaatataa gatttgccgg ggcatcaagg agggccgcct   2340

cactaagccc atcgtctgct ggtgcatcgg gacgtgtgcc accatgttct cctctgaggt   2400

ccagtttggc catgctggag cttgtgccaa ccaggcttct gaaactgcag tagccaagaa   2460

ccaggctttg aaggaagcag gagtgtttgt gccccggagc tttgatgagc ttggagagat   2520

catccagtct gtatacgaag atctcgtggc caatggagtc attgtacctg cccaggaggt   2580

gccgccccca accgtgccca tggactactc ctgggccagg gagcttggtt tgatccgcaa   2640

acctgcctcg ttcatgacca gcatctgcga tgagcgagga caggagctca tctacgcggg   2700

catgcccatc actgaggtct tcaaggaaga gatgggcatt ggcggggtcc tcggcctcct   2760

ctggttccag aaaaggttgc ctaagtactc ttgccagttc attgagatgt gtctgatggt   2820

gacagctgat cacgggccag ccgtctctgg agcccacaac accatcattt gtgcgcgagc   2880

tgggaaagac ctggtctcca gcctcacctc ggggctgctc accatcgggg atcggtttgg   2940

gggtgccttg gatgcagcag ccaagatgtt cagtaaagcc tttgacagtg gcattatccc   3000

catggagttt gtgaacaaga tgaagaagga agggaagctg atcatgggca ttggtcaccg   3060

agtgaagtcg ataaacaacc cagacatgcg agtgcagatc ctcaaagatt acgtcaggca   3120

gcacttccct gccactcctc tgctcgatta tgcactggaa gtagagaaga ttaccacctc   3180

gaagaagcca aatcttatcc tgaatgtaga tggtctcatc ggagtcgcat ttgtagacat   3240

gcttagaaac tgtgggtcct ttactcggga ggaagctgat gaatatattg acattggagc   3300

cctcaatggc atctttgtgc tgggaaggag tatggggttc attggacact atcttgatca   3360

gaagaggctg aagcaggggc tgtatcgtca tccgtgggat gatatttcat atgttcttcc   3420

ggaacacatg agcatgtaac agagccagga accctactgc agtaaactga agacaagatc   3480

tcttccccca agaaaaagtg tacagacagc tggcagtgga gcctgcttta tttagcaggg   3540

gcctggaatg taaacagcca ctggggtaca ggcaccgaag accaacatcc acaggctaac   3600

accccttcag tccacacaaa gaagcttcat atttttttta taagcataga aataaaaacc   3660

aagccaatat ttgtgacttt gctctgctac ctgctgtatt tattatatgg aagcatctaa   3720

gtactgtcag gatggggtct tcctcattgt agggcgttag gatgttgctt tctttttcca   3780

ttagttaaac atttttttct cctttggagg aagggaatga aacatttatg gcctcaagat   3840

actatacatt taaagcaccc caatgtctct cttttttttt ttttacttcc ctttcttctt   3900

ccttatataa catgaagaac attgtattaa tctgattttt aaagatcttt ttgtatgtta   3960

cgtgttaagg gcttgtttgg tatcccactg aaatgttctg tgttgcagac cagagtctgt   4020

ttatgtcagg gggatggggc cattgcatcc ttagccattg tcacaaaata tgtggagtag   4080

taacttaata tgtaaagttg taacatacat acatttaaaa tggaaatgca gaaagctgtg   4140

aaatgtcttg tgtcttatgt tctctgtatt tatgcagctg atttgtctgt ctgtaactga   4200

agtgtgggtc caaggactcc taactacttt gcatctgtaa tccacaaaga ttctgggcag   4260

ctgccacctc agtctcttct ctgtattatc atagtctggt ttaaataaac tatatagtaa   4320

caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                         4420


<210>  3443
<211>  1091
<212>  PRT
<213>  Homosapiens

<400>  3443

Met Ser Ala Lys Ala Ile Ser Glu Gln Thr Gly Lys Glu Leu Leu Tyr 
1               5                   10                  15      


Lys Phe Ile Cys Thr Thr Ser Ala Ile Gln Asn Arg Phe Lys Tyr Ala 
            20                  25                  30          


Arg Val Thr Pro Asp Thr Asp Trp Ala Arg Leu Leu Gln Asp His Pro 
        35                  40                  45              


Trp Leu Leu Ser Gln Asn Leu Val Val Lys Pro Asp Gln Leu Ile Lys 
    50                  55                  60                  


Arg Arg Gly Lys Leu Gly Leu Val Gly Val Asn Leu Thr Leu Asp Gly 
65                  70                  75                  80  


Val Lys Ser Trp Leu Lys Pro Arg Leu Gly Gln Glu Ala Thr Val Gly 
                85                  90                  95      


Lys Ala Thr Gly Phe Leu Lys Asn Phe Leu Ile Glu Pro Phe Val Pro 
            100                 105                 110         


His Ser Gln Ala Glu Glu Phe Tyr Val Cys Ile Tyr Ala Thr Arg Glu 
        115                 120                 125             


Gly Asp Tyr Val Leu Phe His His Glu Gly Gly Val Asp Val Gly Asp 
    130                 135                 140                 


Val Asp Ala Lys Ala Gln Lys Leu Leu Val Gly Val Asp Glu Lys Leu 
145                 150                 155                 160 


Asn Pro Glu Asp Ile Lys Lys His Leu Leu Val His Ala Pro Glu Asp 
                165                 170                 175     


Lys Lys Glu Ile Leu Ala Ser Phe Ile Ser Gly Leu Phe Asn Phe Tyr 
            180                 185                 190         


Glu Asp Leu Tyr Phe Thr Tyr Leu Glu Ile Asn Pro Leu Val Val Thr 
        195                 200                 205             


Lys Asp Gly Val Tyr Val Leu Asp Leu Ala Ala Lys Val Asp Ala Thr 
    210                 215                 220                 


Ala Asp Tyr Ile Cys Lys Val Lys Trp Gly Asp Ile Glu Phe Pro Pro 
225                 230                 235                 240 


Pro Phe Gly Arg Glu Ala Tyr Pro Glu Glu Ala Tyr Ile Ala Asp Leu 
                245                 250                 255     


Asp Ala Lys Ser Gly Ala Ser Leu Lys Leu Thr Leu Leu Asn Pro Lys 
            260                 265                 270         


Gly Arg Ile Trp Thr Met Val Ala Gly Gly Gly Ala Ser Val Val Tyr 
        275                 280                 285             


Ser Asp Thr Ile Cys Asp Leu Gly Gly Val Asn Glu Leu Ala Asn Tyr 
    290                 295                 300                 


Gly Glu Tyr Ser Gly Ala Pro Ser Glu Gln Gln Thr Tyr Asp Tyr Ala 
305                 310                 315                 320 


Lys Thr Ile Leu Ser Leu Met Thr Arg Glu Lys His Pro Asp Gly Lys 
                325                 330                 335     


Ile Leu Ile Ile Gly Gly Ser Ile Ala Asn Phe Thr Asn Val Ala Ala 
            340                 345                 350         


Thr Phe Lys Gly Ile Val Arg Ala Ile Arg Asp Tyr Gln Gly Pro Leu 
        355                 360                 365             


Lys Glu His Glu Val Thr Ile Phe Val Arg Arg Gly Gly Pro Asn Tyr 
    370                 375                 380                 


Gln Glu Gly Leu Arg Val Met Gly Glu Val Gly Lys Thr Thr Gly Ile 
385                 390                 395                 400 


Pro Ile His Val Phe Gly Thr Glu Thr His Met Thr Ala Ile Val Gly 
                405                 410                 415     


Met Ala Leu Gly His Arg Pro Ile Pro Asn Gln Pro Pro Thr Ala Ala 
            420                 425                 430         


His Thr Ala Asn Phe Leu Leu Asn Ala Ser Gly Ser Thr Ser Thr Pro 
        435                 440                 445             


Ala Pro Ser Arg Thr Ala Ser Phe Ser Glu Ser Arg Ala Asp Glu Val 
    450                 455                 460                 


Ala Pro Ala Lys Lys Ala Lys Pro Ala Met Pro Gln Gly Lys Ser Thr 
465                 470                 475                 480 


Thr Leu Phe Ser Arg His Thr Lys Ala Ile Val Trp Gly Met Gln Thr 
                485                 490                 495     


Arg Ala Val Gln Gly Met Leu Asp Phe Asp Tyr Val Cys Ser Arg Asp 
            500                 505                 510         


Glu Pro Ser Val Ala Ala Met Val Tyr Pro Phe Thr Gly Asp His Lys 
        515                 520                 525             


Gln Lys Phe Tyr Trp Gly His Lys Glu Ile Leu Ile Pro Val Phe Lys 
    530                 535                 540                 


Asn Met Ala Asp Ala Met Arg Lys His Pro Glu Val Asp Val Leu Ile 
545                 550                 555                 560 


Asn Phe Ala Ser Leu Arg Ser Ala Tyr Asp Ser Thr Met Glu Thr Met 
                565                 570                 575     


Asn Tyr Ala Gln Ile Arg Thr Ile Ala Ile Ile Ala Glu Gly Ile Pro 
            580                 585                 590         


Glu Ala Leu Thr Arg Lys Leu Ile Lys Lys Ala Asp Gln Lys Gly Val 
        595                 600                 605             


Thr Ile Ile Gly Pro Ala Thr Val Gly Gly Ile Lys Pro Gly Cys Phe 
    610                 615                 620                 


Lys Ile Gly Asn Thr Gly Gly Met Leu Asp Asn Ile Leu Ala Ser Lys 
625                 630                 635                 640 


Leu Tyr Arg Pro Gly Ser Val Ala Tyr Val Ser Arg Ser Gly Gly Met 
                645                 650                 655     


Ser Asn Glu Leu Asn Asn Ile Ile Ser Arg Thr Thr Asp Gly Val Tyr 
            660                 665                 670         


Glu Gly Val Ala Ile Gly Gly Asp Arg Tyr Pro Gly Ser Thr Phe Met 
        675                 680                 685             


Asp His Val Leu Arg Tyr Gln Asp Thr Pro Gly Val Lys Met Ile Val 
    690                 695                 700                 


Val Leu Gly Glu Ile Gly Gly Thr Glu Glu Tyr Lys Ile Cys Arg Gly 
705                 710                 715                 720 


Ile Lys Glu Gly Arg Leu Thr Lys Pro Ile Val Cys Trp Cys Ile Gly 
                725                 730                 735     


Thr Cys Ala Thr Met Phe Ser Ser Glu Val Gln Phe Gly His Ala Gly 
            740                 745                 750         


Ala Cys Ala Asn Gln Ala Ser Glu Thr Ala Val Ala Lys Asn Gln Ala 
        755                 760                 765             


Leu Lys Glu Ala Gly Val Phe Val Pro Arg Ser Phe Asp Glu Leu Gly 
    770                 775                 780                 


Glu Ile Ile Gln Ser Val Tyr Glu Asp Leu Val Ala Asn Gly Val Ile 
785                 790                 795                 800 


Val Pro Ala Gln Glu Val Pro Pro Pro Thr Val Pro Met Asp Tyr Ser 
                805                 810                 815     


Trp Ala Arg Glu Leu Gly Leu Ile Arg Lys Pro Ala Ser Phe Met Thr 
            820                 825                 830         


Ser Ile Cys Asp Glu Arg Gly Gln Glu Leu Ile Tyr Ala Gly Met Pro 
        835                 840                 845             


Ile Thr Glu Val Phe Lys Glu Glu Met Gly Ile Gly Gly Val Leu Gly 
    850                 855                 860                 


Leu Leu Trp Phe Gln Lys Arg Leu Pro Lys Tyr Ser Cys Gln Phe Ile 
865                 870                 875                 880 


Glu Met Cys Leu Met Val Thr Ala Asp His Gly Pro Ala Val Ser Gly 
                885                 890                 895     


Ala His Asn Thr Ile Ile Cys Ala Arg Ala Gly Lys Asp Leu Val Ser 
            900                 905                 910         


Ser Leu Thr Ser Gly Leu Leu Thr Ile Gly Asp Arg Phe Gly Gly Ala 
        915                 920                 925             


Leu Asp Ala Ala Ala Lys Met Phe Ser Lys Ala Phe Asp Ser Gly Ile 
    930                 935                 940                 


Ile Pro Met Glu Phe Val Asn Lys Met Lys Lys Glu Gly Lys Leu Ile 
945                 950                 955                 960 


Met Gly Ile Gly His Arg Val Lys Ser Ile Asn Asn Pro Asp Met Arg 
                965                 970                 975     


Val Gln Ile Leu Lys Asp Tyr Val Arg Gln His Phe Pro Ala Thr Pro 
            980                 985                 990         


Leu Leu Asp Tyr Ala Leu Glu Val  Glu Lys Ile Thr Thr  Ser Lys Lys 
        995                 1000                 1005             


Pro Asn  Leu Ile Leu Asn Val  Asp Gly Leu Ile Gly  Val Ala Phe 
    1010                 1015                 1020             


Val Asp  Met Leu Arg Asn Cys  Gly Ser Phe Thr Arg  Glu Glu Ala 
    1025                 1030                 1035             


Asp Glu  Tyr Ile Asp Ile Gly  Ala Leu Asn Gly Ile  Phe Val Leu 
    1040                 1045                 1050             


Gly Arg  Ser Met Gly Phe Ile  Gly His Tyr Leu Asp  Gln Lys Arg 
    1055                 1060                 1065             


Leu Lys  Gln Gly Leu Tyr Arg  His Pro Trp Asp Asp  Ile Ser Tyr 
    1070                 1075                 1080             


Val Leu  Pro Glu His Met Ser  Met 
    1085                 1090     


<210>  3444
<211>  2277
<212>  DNA
<213>  Homosapiens

<400>  3444
aaaccagata gaggttctcc agcttttctt tgattgtctc tgctttagcg tctctaaatc     60

cggtcaccat gtcggacccc gaaggcgaga ccttgcgaag cacctttccc tcttatatgg    120

ccgaaggcga gcggctctac ctgtgcgggg aattttctaa agccgcgcag agcttcagca    180

acgctcttta ccttcaggat ggagacaaga actgcctggt tgctcgctca aagtgcttcc    240

tgaagatggg agacttggag agatccctga aggatgctga ggcttcgctc cagagtgacc    300

cagctttctg taaggggatt ttgcaaaagg ctgagacact gtacaccatg ggagactttg    360

agtttgcctt ggtattctat catcgaggct acaagctgag gcctgatcgg gaattcagag    420

ttggcattca gaaagcccag gaagccatca acaactcagt gggaagtcct tcttccatta    480

agctggagaa caaaggggac ctctccttct taagcaagca ggctgagaat ataaaagccc    540

agcagaagcc tcagcccatg aaacacctct tacaccccac caagggagag cccaagtgga    600

aggcctcgct caagagtgag aagactgtcc gccagcttct gggggagctc tacgtggaca    660

aagagtattt ggagaagctc ctattggatg aagacctgat caaaggcacc atgaagggcg    720

gcctgactgt ggaggacctc atcatgacgg gcatcaacta cctggatact cacagcaact    780

tctggaggca gcagaagccg atctacgcca gggagcggga ccggaagctg atgcaagaga    840

aatggctgcg ggaccacaaa cgccgtccct cacagacagc ccattacatc ctcaagagcc    900

tggaggacat tgatatgttg ctcacaagtg gcagtgctga agggagtctt cagaaagctg    960

agaaagtgct gaagaaggta ctggaatgga acaaggaaga ggtacccaac aaggatgaac   1020

tggttggaaa cttgtatagc tgcataggga atgcccagat tgagctgggg cagatggagg   1080

cagccctgca gagccacaga aaggacctgg agatcgccaa ggaatatgac cttcctgatg   1140

caaaatcgag agcccttgac aacattggca gagtttttgc cagagttggg aaattccagc   1200

aagccattga cacgtgggaa gaaaagatcc ctctggcaaa aaccaccctg gagaagacct   1260

ggctgttcca cgagatcggc cgctgctact tggagctgga ccaggcctgg caggcccaga   1320

attatggcga gaagtcccag cagtgtgccg aggaggaagg ggacattgag tggcaactga   1380

atgccagtgt tctggtggcc caggcacaag tgaagctgag agacttcgag tcagccgtga   1440

acaattttga gaaggccctg gagagagcaa agcttgtgca taacaacgag gcgcagcagg   1500

ccatcatcag tgccttggac gatgccaaca agggtatcat cagagaactg aggaaaacca   1560

actacgtgga gaatctcaaa gaaaaaagcg agggagaagc ttcactgtat gaagatagaa   1620

taataacaag agagaaggac atgaggagag tgagagatga gcccgagaag gtggtgaagc   1680

agtgggacca tagtgaggat gagaaagaga cagatgagga cgatgaggct tttggggaag   1740

ctctgcagag cccagcaagc ggaaagcaga gtgtggaagc aggaaaagcc agaagcgatt   1800

tgggagcagt tgccaagggc ctgtcaggag aattaggcac aagatcagga gaaacaggca   1860

ggaagctact agaagctggc agaagagagt caagagaaat ttataggagg ccttcgggag   1920

aattagagca aagactctca ggagaattca gcagacagga accagaagaa ctaaagaaac   1980

tttcagaagt gggcagaaga gagccagaag aactgggaaa aacacaattt ggagaaatag   2040

gagaaacgaa aaaaacagga aatgagatgg aaaaggaata tgaatgaagc catcggtaga   2100

gatgaggatc aggaagctgg tgttcagagg gatcatggga ttttattaaa ctggattttc   2160

aagcgatttg tctgttatag gaaaaatgag ggttttactt ctgctgcttt ccatcactat   2220

tttgccatta aataggtgtc tttcactctt gcaaaaaaaa aaaaaaaaaa aaaaaaa      2277


<210>  3445
<211>  672
<212>  PRT
<213>  Homosapiens

<400>  3445

Met Ser Asp Pro Glu Gly Glu Thr Leu Arg Ser Thr Phe Pro Ser Tyr 
1               5                   10                  15      


Met Ala Glu Gly Glu Arg Leu Tyr Leu Cys Gly Glu Phe Ser Lys Ala 
            20                  25                  30          


Ala Gln Ser Phe Ser Asn Ala Leu Tyr Leu Gln Asp Gly Asp Lys Asn 
        35                  40                  45              


Cys Leu Val Ala Arg Ser Lys Cys Phe Leu Lys Met Gly Asp Leu Glu 
    50                  55                  60                  


Arg Ser Leu Lys Asp Ala Glu Ala Ser Leu Gln Ser Asp Pro Ala Phe 
65                  70                  75                  80  


Cys Lys Gly Ile Leu Gln Lys Ala Glu Thr Leu Tyr Thr Met Gly Asp 
                85                  90                  95      


Phe Glu Phe Ala Leu Val Phe Tyr His Arg Gly Tyr Lys Leu Arg Pro 
            100                 105                 110         


Asp Arg Glu Phe Arg Val Gly Ile Gln Lys Ala Gln Glu Ala Ile Asn 
        115                 120                 125             


Asn Ser Val Gly Ser Pro Ser Ser Ile Lys Leu Glu Asn Lys Gly Asp 
    130                 135                 140                 


Leu Ser Phe Leu Ser Lys Gln Ala Glu Asn Ile Lys Ala Gln Gln Lys 
145                 150                 155                 160 


Pro Gln Pro Met Lys His Leu Leu His Pro Thr Lys Gly Glu Pro Lys 
                165                 170                 175     


Trp Lys Ala Ser Leu Lys Ser Glu Lys Thr Val Arg Gln Leu Leu Gly 
            180                 185                 190         


Glu Leu Tyr Val Asp Lys Glu Tyr Leu Glu Lys Leu Leu Leu Asp Glu 
        195                 200                 205             


Asp Leu Ile Lys Gly Thr Met Lys Gly Gly Leu Thr Val Glu Asp Leu 
    210                 215                 220                 


Ile Met Thr Gly Ile Asn Tyr Leu Asp Thr His Ser Asn Phe Trp Arg 
225                 230                 235                 240 


Gln Gln Lys Pro Ile Tyr Ala Arg Glu Arg Asp Arg Lys Leu Met Gln 
                245                 250                 255     


Glu Lys Trp Leu Arg Asp His Lys Arg Arg Pro Ser Gln Thr Ala His 
            260                 265                 270         


Tyr Ile Leu Lys Ser Leu Glu Asp Ile Asp Met Leu Leu Thr Ser Gly 
        275                 280                 285             


Ser Ala Glu Gly Ser Leu Gln Lys Ala Glu Lys Val Leu Lys Lys Val 
    290                 295                 300                 


Leu Glu Trp Asn Lys Glu Glu Val Pro Asn Lys Asp Glu Leu Val Gly 
305                 310                 315                 320 


Asn Leu Tyr Ser Cys Ile Gly Asn Ala Gln Ile Glu Leu Gly Gln Met 
                325                 330                 335     


Glu Ala Ala Leu Gln Ser His Arg Lys Asp Leu Glu Ile Ala Lys Glu 
            340                 345                 350         


Tyr Asp Leu Pro Asp Ala Lys Ser Arg Ala Leu Asp Asn Ile Gly Arg 
        355                 360                 365             


Val Phe Ala Arg Val Gly Lys Phe Gln Gln Ala Ile Asp Thr Trp Glu 
    370                 375                 380                 


Glu Lys Ile Pro Leu Ala Lys Thr Thr Leu Glu Lys Thr Trp Leu Phe 
385                 390                 395                 400 


His Glu Ile Gly Arg Cys Tyr Leu Glu Leu Asp Gln Ala Trp Gln Ala 
                405                 410                 415     


Gln Asn Tyr Gly Glu Lys Ser Gln Gln Cys Ala Glu Glu Glu Gly Asp 
            420                 425                 430         


Ile Glu Trp Gln Leu Asn Ala Ser Val Leu Val Ala Gln Ala Gln Val 
        435                 440                 445             


Lys Leu Arg Asp Phe Glu Ser Ala Val Asn Asn Phe Glu Lys Ala Leu 
    450                 455                 460                 


Glu Arg Ala Lys Leu Val His Asn Asn Glu Ala Gln Gln Ala Ile Ile 
465                 470                 475                 480 


Ser Ala Leu Asp Asp Ala Asn Lys Gly Ile Ile Arg Glu Leu Arg Lys 
                485                 490                 495     


Thr Asn Tyr Val Glu Asn Leu Lys Glu Lys Ser Glu Gly Glu Ala Ser 
            500                 505                 510         


Leu Tyr Glu Asp Arg Ile Ile Thr Arg Glu Lys Asp Met Arg Arg Val 
        515                 520                 525             


Arg Asp Glu Pro Glu Lys Val Val Lys Gln Trp Asp His Ser Glu Asp 
    530                 535                 540                 


Glu Lys Glu Thr Asp Glu Asp Asp Glu Ala Phe Gly Glu Ala Leu Gln 
545                 550                 555                 560 


Ser Pro Ala Ser Gly Lys Gln Ser Val Glu Ala Gly Lys Ala Arg Ser 
                565                 570                 575     


Asp Leu Gly Ala Val Ala Lys Gly Leu Ser Gly Glu Leu Gly Thr Arg 
            580                 585                 590         


Ser Gly Glu Thr Gly Arg Lys Leu Leu Glu Ala Gly Arg Arg Glu Ser 
        595                 600                 605             


Arg Glu Ile Tyr Arg Arg Pro Ser Gly Glu Leu Glu Gln Arg Leu Ser 
    610                 615                 620                 


Gly Glu Phe Ser Arg Gln Glu Pro Glu Glu Leu Lys Lys Leu Ser Glu 
625                 630                 635                 640 


Val Gly Arg Arg Glu Pro Glu Glu Leu Gly Lys Thr Gln Phe Gly Glu 
                645                 650                 655     


Ile Gly Glu Thr Lys Lys Thr Gly Asn Glu Met Glu Lys Glu Tyr Glu 
            660                 665                 670         


<210>  3446
<211>  5222
<212>  DNA
<213>  Homosapiens

<400>  3446
gggtgcccgc tccgcccccc gggctatgta aagcggccgg gctcgggtcg tgccaccgct     60

ggactcccgt gtccctccgc gcaggcgggc ggccccggag cgctggtgcc ggcagaggcg    120

gcgacggtgg cgcccctcct catcatgaac agaggcttct cccgaaaaag ccacacattc    180

ctgcccaaga tcttcttccg caagatgtca tcctcagggg ccaaggacaa gcctgagctg    240

cagtttccct tccttcagga tgaggacaca gtggccacgc tgctagagtg caagacgctc    300

ttcatcttgc gcggcctgcc aggaagcggc aagtccacgc tggcacgggt catcgtggac    360

aagtaccgtg atggcaccaa gatggtgtcg gctgacgctt acaagatcac ccccggcgct    420

cgaggagcct tctccgagga gtacaagcgg ctcgatgagg acctggctgc ctactgccgc    480

cgccgggaca tcagaattct tgtgcttgat gacaccaacc acgaacggga acggctggag    540

cagctctttg aaatggccga ccagtaccag taccaggtgg tgctggtgga gcccaagacg    600

gcgtggcggc tggactgtgc ccagctcaag gagaagaacc agtggcagct gtcggctgat    660

gacctgaaga agctgaagcc tgggctggag aaggacttcc tgccgctcta cttcggctgg    720

ttcctgacca agaagagctc tgagaccctc cgcaaagccg gccaggtctt cctggaagag    780

ctggggaacc acaaggcctt caagaaggag ctgcgacaat tcgtccctgg ggatgagccc    840

agggagaaga tggacttggt cacctacttt ggaaagagac ccccaggcgt gctgcattgc    900

acaaccaagt tttgtgacta cgggaaggct cccggggcag aggagtacgc tcaacaagat    960

gtgttaaaga aatcttactc caaggccttc acgctgacca tctctgccct ctttgtgaca   1020

cccaagacga ctggggcccg ggtggagtta agcgagcagc aactgcagtt gtggccgagt   1080

gatgtggaca agctgtcacc cactgacaac ctgccgcggg ggagccgcgc ccacatcacc   1140

ctcggctgtg cagctgacgt agaggccgtg cagacgggcc ttgacctctt agagattctg   1200

cggcaggaga aggggggcag ccgaggcgag gaggtgggcg agctaagccg gggcaagctc   1260

tattccttgg gcaatgggcg ctggatgctg accctggcca agaacatgga ggtcagggcc   1320

atcttcacgg ggtactacgg gaaaggcaaa cctgtgccca cgcaaggtag ccggaagggg   1380

ggcgccttgc agtcctgcac catcatatga gtgttctcac caccacttat gcccctagaa   1440

gggaagggga gagggaaacg tgccctctgt ttgatccttg ttttgtgaca tttttttttt   1500

tttttttttt actcaaagtt aacctacctg taacttttta aaaacttgta aaataactga   1560

ccctcccttc ctgtccgccc tcttcccctc taatgctcac gctcccaaca caaggtgggc   1620

agggaggcac cattcaggaa cctggaccaa agctgacgag gctgggccaa gccagggatg   1680

gggccacagc cagaaccccg agccctactt ccaggttctg gttagctcag ccccagccca   1740

gcccagctgc tctgcccaga gctgggtgag tggggagaca cctcagagcc ccgcaaaacc   1800

cactgaccgg aggcaaaagg cagtggggct gggggtagtt ttccatggtc acagagaact   1860

agtggtggct ctgagaaggg gaggacctct gggctttgat tccatctcct tgtctttttt   1920

ctttgttttt agagacaggg tcctgctatt tcccaagctg gagtgcagtg gtgcgatcat   1980

ggctcactgc agcctcgaac tcctgggctc aagcaatcct cctgagtgat cccatttctt   2040

aatcagtgta gccccaagaa ggctggggct atttaccagg gtagaaaaag gagcttacct   2100

cccacctttg gtcctaagtc cctgccccct ccccttcaca ccataactag gtaacagttt   2160

gataactagg gaagaaagca gaacagttaa gcagccgcca catccccgct ggctgggggc   2220

ctcactccag gaaggggctg gactggctgt cctttccagt ggcctggctc cgctgtgtgg   2280

atggggagat cggggccaga ggcagaaccc tggtgaggaa gctccagtcc tgctctctac   2340

ccagcccatc ttgcctccat ggtgcctctg gaggcctctg ggcctcctct aacaggggct   2400

ggtgggcacc aagagccaat ggagtagacc cctggctggt aagggccaag tcccaccggt   2460

tgcttctggg aaggggtttc taacactagt ctgtgtgctg tggttcctgg ggtgccctcc   2520

actgccctct gttcagtaac agggccttgc taatcgggtt gtcactcaac aaaagtgctt   2580

tggatttaag ttactatcct ggctttgccc aacctcagca acctgtaaga ctgataatga   2640

aataaatcat gttaatccta gctgtgtgca gtctctctta cccttctgtg cccagctcag   2700

tcttccctag ggctgggtgt attaggactg gctttgtccc acagcttggg gccatcggtc   2760

ctgtctcccc tctgctggcc gggcacagct gtggtgaggt tgggcagctg aacagtgttg   2820

gctttcatga ggaggcagaa agcagaggct ggcctcagac tcatacagaa ggtgggggtt   2880

ggctgggtac gagggatgtg gagcacaaaa gcctctcatc ccccattaac cagggcacca   2940

agcccacagg tgtccccagc ccactggatc agaaagagtt cagtaagacc ggaagctcct   3000

ggtatgggtt tctcccagtt ctctagggaa ggccacctgc aggtcactga aacttcaagc   3060

accagggaag atctaacatt tgagtccctt ccaggccatc agaggcctag tcagccacat   3120

gggaaacttc caagacctga ctcaggcatc attccaccat ggctaaggca ccagccgggg   3180

aagacttgaa agaaaggggc aggagctcag atgaagagaa atcctaagtt acctttctag   3240

gtcaaggcct gtccctggcc atctctgaac ttcagctaga gcttcaagtc tgtgcctgga   3300

gctcctggga aggctactca ccttgaacac cacgcttgac aggacagcat ggtgcatgcc   3360

gctgcatccg tgagcagtgt gtctcctgca tgcagaaagg gagcagagaa ggccaggggc   3420

ttttgctaaa aatagtggcc agaccagagc tctggagcca cctgtcccac ctcaaatggg   3480

tctgggggtc aggaggcagg gttttatctc tgtctaccat ctccctcgaa cccacactgc   3540

aacaggaact gtgagagtct ttgtaagtaa actgccctgt ctaggtcagt acccacctga   3600

gctttggacg cacacagctt ttagtaccca cctgagcttt ggacacacac agcttctagt   3660

gatttctggg gccccaccgt aaagtgagca tgctttctga actcgcttct ctgtgactga   3720

tgttaggctg ggcccagagg cacagccggg gcctgcctag cactcacatg ctggacaggt   3780

ctgggagagg cagagtgccc cacctgccac taggctgggt gcccacagcc cgcatgcagc   3840

agcttgctgc accccaagtc caggtcgggc tcagctctgg ctcacagact ggagacaatg   3900

cagatgccag agcaaagggc caggaagggt caaaacattt tattctcttt tttttttctt   3960

ttttaataaa gttaaacagt aaaacaaaaa ttcacaagct gcctccctgt ccacccccgc   4020

ctccctcccc tgccctcggt cttcggcatt ggttcccttt gctccacccc actcacagag   4080

acacagggca tccaactgag aaaacgaaac tgctctaagc acacggagac gtgatgaagg   4140

gaggaggtga actgtttcca cattcaagat taaactgagt gaatctgcat tttctgggtt   4200

ctgggtggtt gcccttcatt agccaaattg aaaaaagaaa ttccctggac cagatgctga   4260

aagagaaaag aggggttggt agttggctat ggattttcta aggaagatca ctttgctctg   4320

attatggaaa agtcttcaag ggctgcttca aactcaaaca cagagagaaa ctctatgggt   4380

atcaaacagc tcaggctgtt tttgggtgca agagggagca cgtgactgta ttatacatgg   4440

gtagcttctg acctcagcat tatctatata gtacctttgc tcttgcagag aagccttggt   4500

actaggcagt tagagatgcc tccctgaccc tgcagagatg cggtggctaa aggtcccaag   4560

gcaaggggtg cctgggaacc ttcctgtctt catccttagc aacagccgag tggatagatg   4620

ccctgctaga tgagaattca gctgcccccg ctcatgggcc cctctgactc ccaaagagct   4680

gcctaagagg caatgagtgt gttggcttgt gatctgggaa ctcccaagaa cagcaggccc   4740

acctaccttc aaagctgaag ccgccaggac cgccaaagaa tgccttgaag atattgtttg   4800

gatcaaaatc tgtagagcag ggcaagtaac atggaaggga agaaaaggtg aaaaattaga   4860

aatgttcgaa gagaactgat gacactgaga acagatctcc aaagctttcc tggagagtct   4920

cactcccctc ctttcccaac acttcagact gcaagtgagc aaacctgccc catcccgtgc   4980

aaaacatgct acctgatccc actcctagga catgttccct tctccttcca actgctgccc   5040

caaaggaagc tttctctgct tcagcttgct tcattgggct gttttctcaa caaatggaat   5100

gccatttgca cttacacaag actttcccca tactctgtct ccctataatg ctggagcggc   5160

tactaaaaag gataaaatgt atcacttaaa tgttaccaaa aataaatata agagcaagat   5220

ct                                                                  5222


<210>  3447
<211>  421
<212>  PRT
<213>  Homosapiens

<400>  3447

Met Asn Arg Gly Phe Ser Arg Lys Ser His Thr Phe Leu Pro Lys Ile 
1               5                   10                  15      


Phe Phe Arg Lys Met Ser Ser Ser Gly Ala Lys Asp Lys Pro Glu Leu 
            20                  25                  30          


Gln Phe Pro Phe Leu Gln Asp Glu Asp Thr Val Ala Thr Leu Leu Glu 
        35                  40                  45              


Cys Lys Thr Leu Phe Ile Leu Arg Gly Leu Pro Gly Ser Gly Lys Ser 
    50                  55                  60                  


Thr Leu Ala Arg Val Ile Val Asp Lys Tyr Arg Asp Gly Thr Lys Met 
65                  70                  75                  80  


Val Ser Ala Asp Ala Tyr Lys Ile Thr Pro Gly Ala Arg Gly Ala Phe 
                85                  90                  95      


Ser Glu Glu Tyr Lys Arg Leu Asp Glu Asp Leu Ala Ala Tyr Cys Arg 
            100                 105                 110         


Arg Arg Asp Ile Arg Ile Leu Val Leu Asp Asp Thr Asn His Glu Arg 
        115                 120                 125             


Glu Arg Leu Glu Gln Leu Phe Glu Met Ala Asp Gln Tyr Gln Tyr Gln 
    130                 135                 140                 


Val Val Leu Val Glu Pro Lys Thr Ala Trp Arg Leu Asp Cys Ala Gln 
145                 150                 155                 160 


Leu Lys Glu Lys Asn Gln Trp Gln Leu Ser Ala Asp Asp Leu Lys Lys 
                165                 170                 175     


Leu Lys Pro Gly Leu Glu Lys Asp Phe Leu Pro Leu Tyr Phe Gly Trp 
            180                 185                 190         


Phe Leu Thr Lys Lys Ser Ser Glu Thr Leu Arg Lys Ala Gly Gln Val 
        195                 200                 205             


Phe Leu Glu Glu Leu Gly Asn His Lys Ala Phe Lys Lys Glu Leu Arg 
    210                 215                 220                 


Gln Phe Val Pro Gly Asp Glu Pro Arg Glu Lys Met Asp Leu Val Thr 
225                 230                 235                 240 


Tyr Phe Gly Lys Arg Pro Pro Gly Val Leu His Cys Thr Thr Lys Phe 
                245                 250                 255     


Cys Asp Tyr Gly Lys Ala Pro Gly Ala Glu Glu Tyr Ala Gln Gln Asp 
            260                 265                 270         


Val Leu Lys Lys Ser Tyr Ser Lys Ala Phe Thr Leu Thr Ile Ser Ala 
        275                 280                 285             


Leu Phe Val Thr Pro Lys Thr Thr Gly Ala Arg Val Glu Leu Ser Glu 
    290                 295                 300                 


Gln Gln Leu Gln Leu Trp Pro Ser Asp Val Asp Lys Leu Ser Pro Thr 
305                 310                 315                 320 


Asp Asn Leu Pro Arg Gly Ser Arg Ala His Ile Thr Leu Gly Cys Ala 
                325                 330                 335     


Ala Asp Val Glu Ala Val Gln Thr Gly Leu Asp Leu Leu Glu Ile Leu 
            340                 345                 350         


Arg Gln Glu Lys Gly Gly Ser Arg Gly Glu Glu Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Gly Lys Leu Tyr Ser Leu Gly Asn Gly Arg Trp Met Leu Thr Leu 
    370                 375                 380                 


Ala Lys Asn Met Glu Val Arg Ala Ile Phe Thr Gly Tyr Tyr Gly Lys 
385                 390                 395                 400 


Gly Lys Pro Val Pro Thr Gln Gly Ser Arg Lys Gly Gly Ala Leu Gln 
                405                 410                 415     


Ser Cys Thr Ile Ile 
            420     


<210>  3448
<211>  1756
<212>  DNA
<213>  Homosapiens

<400>  3448
cggctgccgc ggagtgcgat gtggtaatgg cggcgaccga gccggagctg ctcgacgacc     60

aagaggcgaa gagggaagca gagactttca aggaacaagg aaatgcatac tatgccaaga    120

aagattacaa tgaagcttat aattattata caaaagccat agatatgtgt cctaaaaatg    180

ctagctatta tggtaatcga gcagccacct tgatgatgct tggaaggttc cgggaagctc    240

ttggagatgc acaacagtca gtgaggttgg atgacagttt tgtccgggga catctacgag    300

agggcaagtg ccacctctct ctggggaatg ccatggcagc atgtcgcagc ttccagagag    360

ccctagaact ggatcataaa aatgctcagg cacaacaaga gttcaagaat gctaatgcag    420

tcatggaata tgagaaaata gcagaaacag attttgagaa gcgagatttt cggaaggttg    480

ttttctgcat ggaccgtgcc ctagaatttg cccctgcctg ccatcgcttc aaaatcctca    540

aggcagaatg tttagcaatg ctgggtcgtt atccggaagc acagtctgtg gctagtgaca    600

ttctacgaat ggattccacc aatgcagatg ctctgtatgt acgaggtctt tgcctttatt    660

acgaagattg tattgagaag gcagttcagt ttttcgtaca ggctctcagg atggctcctg    720

accacgagaa ggcctgcatt gcctgcagaa atgccaaagc actcaaagca aagaaagaag    780

atgggaataa agcatttaag gaaggaaatt acaaactagc atatgaactg tacacagaag    840

ccctggggat agaccccaac aatataaaaa caaatgctaa actctactgt aatcggggta    900

cggttaattc caagcttagg aaactagatg atgcaataga agactgcaca aatgcagtga    960

agcttgatga cacttacata aaagcctact tgagaagagc tcagtgttac atggacacag   1020

aacagtatga agaagcagta cgagactatg aaaaagtata ccagacagag aaaacaaaag   1080

aacacaaaca gctcctaaaa aatgcgcagc tggaactgaa gaagagtaag aggaaagatt   1140

actacaagat tctaggagtg gacaagaatg cctctgagga cgagatcaag aaagcttatc   1200

ggaaacgggc cttgatgcac catccagatc ggcatagtgg agccagtgct gaggttcaga   1260

aggaggagga gaagaagttc aaggaagttg gagaggcctt tactatcctc tctgatccca   1320

agaaaaagac tcgctatgac agtggacagg acctagatga ggagggcatg aatatgggtg   1380

attttgatcc aaacaatatc ttcaaggcat tctttggcgg tcctggcggc ttcagctttg   1440

aagcatctgg tccagggaat ttcttttttc aatttggcta atgaagggca accacccaga   1500

acccagaaaa tgcagattca ctcagtttaa tcttgaatgt ggaaacagtt cacctcctcc   1560

cttcatcacg tctccgtgtg cttagagcag tttcgttttc tcagttggat gccctgtgtc   1620

tctgtgagtg gggtggagca aagggaacca atgccgaaga ccgagggcag gggagggagg   1680

cgggggtgga cagggaggca gcttgtgaat ttttgtttta ctgtttaact ttattaaaaa   1740

agaaaaaaaa aaaaaa                                                   1756


<210>  3449
<211>  484
<212>  PRT
<213>  Homosapiens

<400>  3449

Met Ala Ala Thr Glu Pro Glu Leu Leu Asp Asp Gln Glu Ala Lys Arg 
1               5                   10                  15      


Glu Ala Glu Thr Phe Lys Glu Gln Gly Asn Ala Tyr Tyr Ala Lys Lys 
            20                  25                  30          


Asp Tyr Asn Glu Ala Tyr Asn Tyr Tyr Thr Lys Ala Ile Asp Met Cys 
        35                  40                  45              


Pro Lys Asn Ala Ser Tyr Tyr Gly Asn Arg Ala Ala Thr Leu Met Met 
    50                  55                  60                  


Leu Gly Arg Phe Arg Glu Ala Leu Gly Asp Ala Gln Gln Ser Val Arg 
65                  70                  75                  80  


Leu Asp Asp Ser Phe Val Arg Gly His Leu Arg Glu Gly Lys Cys His 
                85                  90                  95      


Leu Ser Leu Gly Asn Ala Met Ala Ala Cys Arg Ser Phe Gln Arg Ala 
            100                 105                 110         


Leu Glu Leu Asp His Lys Asn Ala Gln Ala Gln Gln Glu Phe Lys Asn 
        115                 120                 125             


Ala Asn Ala Val Met Glu Tyr Glu Lys Ile Ala Glu Thr Asp Phe Glu 
    130                 135                 140                 


Lys Arg Asp Phe Arg Lys Val Val Phe Cys Met Asp Arg Ala Leu Glu 
145                 150                 155                 160 


Phe Ala Pro Ala Cys His Arg Phe Lys Ile Leu Lys Ala Glu Cys Leu 
                165                 170                 175     


Ala Met Leu Gly Arg Tyr Pro Glu Ala Gln Ser Val Ala Ser Asp Ile 
            180                 185                 190         


Leu Arg Met Asp Ser Thr Asn Ala Asp Ala Leu Tyr Val Arg Gly Leu 
        195                 200                 205             


Cys Leu Tyr Tyr Glu Asp Cys Ile Glu Lys Ala Val Gln Phe Phe Val 
    210                 215                 220                 


Gln Ala Leu Arg Met Ala Pro Asp His Glu Lys Ala Cys Ile Ala Cys 
225                 230                 235                 240 


Arg Asn Ala Lys Ala Leu Lys Ala Lys Lys Glu Asp Gly Asn Lys Ala 
                245                 250                 255     


Phe Lys Glu Gly Asn Tyr Lys Leu Ala Tyr Glu Leu Tyr Thr Glu Ala 
            260                 265                 270         


Leu Gly Ile Asp Pro Asn Asn Ile Lys Thr Asn Ala Lys Leu Tyr Cys 
        275                 280                 285             


Asn Arg Gly Thr Val Asn Ser Lys Leu Arg Lys Leu Asp Asp Ala Ile 
    290                 295                 300                 


Glu Asp Cys Thr Asn Ala Val Lys Leu Asp Asp Thr Tyr Ile Lys Ala 
305                 310                 315                 320 


Tyr Leu Arg Arg Ala Gln Cys Tyr Met Asp Thr Glu Gln Tyr Glu Glu 
                325                 330                 335     


Ala Val Arg Asp Tyr Glu Lys Val Tyr Gln Thr Glu Lys Thr Lys Glu 
            340                 345                 350         


His Lys Gln Leu Leu Lys Asn Ala Gln Leu Glu Leu Lys Lys Ser Lys 
        355                 360                 365             


Arg Lys Asp Tyr Tyr Lys Ile Leu Gly Val Asp Lys Asn Ala Ser Glu 
    370                 375                 380                 


Asp Glu Ile Lys Lys Ala Tyr Arg Lys Arg Ala Leu Met His His Pro 
385                 390                 395                 400 


Asp Arg His Ser Gly Ala Ser Ala Glu Val Gln Lys Glu Glu Glu Lys 
                405                 410                 415     


Lys Phe Lys Glu Val Gly Glu Ala Phe Thr Ile Leu Ser Asp Pro Lys 
            420                 425                 430         


Lys Lys Thr Arg Tyr Asp Ser Gly Gln Asp Leu Asp Glu Glu Gly Met 
        435                 440                 445             


Asn Met Gly Asp Phe Asp Pro Asn Asn Ile Phe Lys Ala Phe Phe Gly 
    450                 455                 460                 


Gly Pro Gly Gly Phe Ser Phe Glu Ala Ser Gly Pro Gly Asn Phe Phe 
465                 470                 475                 480 


Phe Gln Phe Gly 
                


<210>  3450
<211>  2968
<212>  DNA
<213>  Homosapiens

<400>  3450
cgccgcgccg cttcccccac ctcgcaccag acctctgaaa ttgccctcgg agactcggcc     60

tctcctataa ggacgatcgt cctctcagct ggagaacaag gccatgcctc agctcctacg    120

ccaggcggaa gcgggagagg aaggccgacc cccaagagcg ccccttcagg gggtccatcc    180

ggccttgatc tcagatgggg gggtgtttgc ggagggcggg gcatcgcctc aacagctggg    240

ggctgcatca tggcaggaac gagtttccct gagccacgga gctgcaggtc gcctcctcta    300

ctaccctgct acccggttac ctcttcgcct cttggtcgtc gagcagctcc ggctcggtcg    360

ccgccattac cacatcgcac tccgcggcag ccgccatctt accgccggga ccagagagct    420

gggtgggagg ccggcggtga agagcacttc cggttggagc atagagcagc tccgcggcgc    480

ctcgcccaga agggctccct cgggctcgtc taccagagag aggctccgct tggggccaga    540

gcggcctccc gcccccggat gtccacggtg gtctccgcgc cggggcggga gcccaggggc    600

tgtgccggtt gaaaactaag catggggaag agctgcaagg tggtcgtgtg tggccaggcg    660

tctgtgggca aaacttcaat cctggagcag cttctgtatg ggaaccatgt agtgggttcg    720

gagatgatcg agacgcagga ggacatctac gtgggctcca ttgagacaga ccggggggtg    780

cgagagcagg tgcgtttcta tgacacccgg gggctccgag atggggccga actgccccga    840

cactgcttct cttgcactga tggctacgtc ctggtctata gcacagatag cagagagtct    900

tttcagcgtg tggagctgct caagaaggag attgacaaat ccaaggacaa gaaggaggtc    960

accatcgtgg tccttggcaa caagtgtgac ttacaggagc agcggcgtgt agacccagat   1020

gtggctcagc actgggccaa gtcagagaag gtgaagctgt gggaggtgtc agtggcggac   1080

cggcgctccc tcctggagcc ctttgtctac ttggccagca agatgacgca accccagagc   1140

aagtctgcct tccccctcag ccggaagaac aagggcagcg gctccttgga tggctgaaga   1200

gctgccgttc ctctttcacg atcccagccc catttcagtg tctggggctc tggtagatgt   1260

gttgagggca aagtagagga caagctgtct ttcccagtca gccagggagc tccccgccag   1320

gccacgcccc agccactttg ctccctctca cctctgggaa gtgcaaatac tcttggttga   1380

catccccttc ctcagccctc ccagcctact ccccatccca gcttttagag gatctgctcc   1440

actgtctcct ggggcagttg tgggtcactg tcccttccag ctgccccaga caggaagcag   1500

agtcaccacg cagcagtgtc ccttcttggg tctgagttcc tattataggt aggggcccca   1560

ccctctgggc ttcccatcag cgacacacac acacttatgg caccagcctg gactccagaa   1620

aaagggtgtc caggtattgt gtgtatgcat ttagttgtgc acacacaaat atgctcctat   1680

actggcatta ggcgtctcct catccctcac cctgaccttt ctcctgtcct tttcttggct   1740

ggaagaagtt ggcctcctgg gagtgtagtt ttctgtttta aatcccccac ccctggctgg   1800

gctcagtggc tcacccctgt aatcccagca ctttgggagg ccaaggcggg tcgattactt   1860

gaggtcagga gttcacgacc agcctggcca acattgtgaa accccatctc tgccaaaaat   1920

acaaaagtta gccgggcgta gtggcacatg cctgtaatcc cagctacccg gggaggctga   1980

ggcaggagaa ttgcttgaac tcagaaggcg gaggctgcag tgagccgaga tcgtgccact   2040

gcactccagc ctggtcaaca gagcaagact ccatctcgaa aaaaaaaaaa aaaattcccc   2100

acccctacca attgttttac ttcctcttcc tgctcaggga gcagatgggc ctcactggtt   2160

gagatggaat agaataactg ggctatgagt caccagccca ctttgtgacc cagcaagacc   2220

tttcccctct ctgggcatca gtttctcatc tgtaagatga ccagagttgc ttagatgatc   2280

tcctagatcc tttccagttc tcttgatttc gtaaagccaa tggcttctcc ctctttaagg   2340

tgctatgcca accagccctg gaggctggga tctgccgctc cctccagcca ccagggggca   2400

ggagtgcact acctgctgtc agtcaccaga gtggccgctc agtgcccagc ccgccagcct   2460

cgctcttgga ggctgctctt tatcctgcct gtggttttca gctcagagct ggacttctat   2520

ttataagtta cctgtattta tatttatatg cccgctctca tggtgaaggc tggacaaggt   2580

gctcctctgg cccctccttc ttacctcaga tgcctgaaca gaacaaggca aacccgtagc   2640

agcctctcag gagctgacag gtcctctttc ggggctcagg agggtgggca cacacccagc   2700

ggcctgcaga gtaagcttat tacccacaac tgtgcccgct ttgtgcttct aaggtgcaca   2760

cctagcctag gtgagacact gcagccaggc aaccaccgac acacgcccct tctcaaagcc   2820

agaggtgagt ggggcaggtg cccggggctg ggtgagtgga attaggacac acacaggctt   2880

gggcttcaag ttcatttatt gatgcattgg ttggacacaa taaaaccaca attgttatca   2940

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                      2968


<210>  3451
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  3451

Met Gly Lys Ser Cys Lys Val Val Val Cys Gly Gln Ala Ser Val Gly 
1               5                   10                  15      


Lys Thr Ser Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Val Val Gly 
            20                  25                  30          


Ser Glu Met Ile Glu Thr Gln Glu Asp Ile Tyr Val Gly Ser Ile Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Arg Glu Gln Val Arg Phe Tyr Asp Thr Arg Gly 
    50                  55                  60                  


Leu Arg Asp Gly Ala Glu Leu Pro Arg His Cys Phe Ser Cys Thr Asp 
65                  70                  75                  80  


Gly Tyr Val Leu Val Tyr Ser Thr Asp Ser Arg Glu Ser Phe Gln Arg 
                85                  90                  95      


Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Ser Lys Asp Lys Lys Glu 
            100                 105                 110         


Val Thr Ile Val Val Leu Gly Asn Lys Cys Asp Leu Gln Glu Gln Arg 
        115                 120                 125             


Arg Val Asp Pro Asp Val Ala Gln His Trp Ala Lys Ser Glu Lys Val 
    130                 135                 140                 


Lys Leu Trp Glu Val Ser Val Ala Asp Arg Arg Ser Leu Leu Glu Pro 
145                 150                 155                 160 


Phe Val Tyr Leu Ala Ser Lys Met Thr Gln Pro Gln Ser Lys Ser Ala 
                165                 170                 175     


Phe Pro Leu Ser Arg Lys Asn Lys Gly Ser Gly Ser Leu Asp Gly 
            180                 185                 190     


<210>  3452
<211>  2492
<212>  DNA
<213>  Homosapiens

<400>  3452
gcggcggggg cggggcctgg aggagcctac accgactctg gaggaagact ggagcctttg     60

cggcggcgct gcccctcccc tggtccccgc gagctcggag ggcccggctg gtgctgcggg    120

ggccccggga ggttgaaaac taagcatggg gaagagctgc aaggtggtcg tgtgtggcca    180

ggcgtctgtg ggcaaaactt caatcctgga gcagcttctg tatgggaacc atgtagtggg    240

ttcggagatg atcgagacgc aggaggacat ctacgtgggc tccattgaga cagaccgggg    300

ggtgcgagag caggtgcgtt tctatgacac ccgggggctc cgagatgggg ccgaactgcc    360

ccgacactgc ttctcttgca ctgatggcta cgtcctggtc tatagcacag atagcagaga    420

gtcttttcag cgtgtggagc tgctcaagaa ggagattgac aaatccaagg acaagaagga    480

ggtcaccatc gtggtccttg gcaacaagtg tgacttacag gagcagcggc gtgtagaccc    540

agatgtggct cagcactggg ccaagtcaga gaaggtgaag ctgtgggagg tgtcagtggc    600

ggaccggcgc tccctcctgg agccctttgt ctacttggcc agcaagatga cgcaacccca    660

gagcaagtct gccttccccc tcagccggaa gaacaagggc agcggctcct tggatggctg    720

aagagctgcc gttcctcttt cacgatccca gccccatttc agtgtctggg gctctggtag    780

atgtgttgag ggcaaagtag aggacaagct gtctttccca gtcagccagg gagctccccg    840

ccaggccacg ccccagccac tttgctccct ctcacctctg ggaagtgcaa atactcttgg    900

ttgacatccc cttcctcagc cctcccagcc tactccccat cccagctttt agaggatctg    960

ctccactgtc tcctggggca gttgtgggtc actgtccctt ccagctgccc cagacaggaa   1020

gcagagtcac cacgcagcag tgtcccttct tgggtctgag ttcctattat aggtaggggc   1080

cccaccctct gggcttccca tcagcgacac acacacactt atggcaccag cctggactcc   1140

agaaaaaggg tgtccaggta ttgtgtgtat gcatttagtt gtgcacacac aaatatgctc   1200

ctatactggc attaggcgtc tcctcatccc tcaccctgac ctttctcctg tccttttctt   1260

ggctggaaga agttggcctc ctgggagtgt agttttctgt tttaaatccc ccacccctgg   1320

ctgggctcag tggctcaccc ctgtaatccc agcactttgg gaggccaagg cgggtcgatt   1380

acttgaggtc aggagttcac gaccagcctg gccaacattg tgaaacccca tctctgccaa   1440

aaatacaaaa gttagccggg cgtagtggca catgcctgta atcccagcta cccggggagg   1500

ctgaggcagg agaattgctt gaactcagaa ggcggaggct gcagtgagcc gagatcgtgc   1560

cactgcactc cagcctggtc aacagagcaa gactccatct cgaaaaaaaa aaaaaaaatt   1620

ccccacccct accaattgtt ttacttcctc ttcctgctca gggagcagat gggcctcact   1680

ggttgagatg gaatagaata actgggctat gagtcaccag cccactttgt gacccagcaa   1740

gacctttccc ctctctgggc atcagtttct catctgtaag atgaccagag ttgcttagat   1800

gatctcctag atcctttcca gttctcttga tttcgtaaag ccaatggctt ctccctcttt   1860

aaggtgctat gccaaccagc cctggaggct gggatctgcc gctccctcca gccaccaggg   1920

ggcaggagtg cactacctgc tgtcagtcac cagagtggcc gctcagtgcc cagcccgcca   1980

gcctcgctct tggaggctgc tctttatcct gcctgtggtt ttcagctcag agctggactt   2040

ctatttataa gttacctgta tttatattta tatgcccgct ctcatggtga aggctggaca   2100

aggtgctcct ctggcccctc cttcttacct cagatgcctg aacagaacaa ggcaaacccg   2160

tagcagcctc tcaggagctg acaggtcctc tttcggggct caggagggtg ggcacacacc   2220

cagcggcctg cagagtaagc ttattaccca caactgtgcc cgctttgtgc ttctaaggtg   2280

cacacctagc ctaggtgaga cactgcagcc aggcaaccac cgacacacgc cccttctcaa   2340

agccagaggt gagtggggca ggtgcccggg gctgggtgag tggaattagg acacacacag   2400

gcttgggctt caagttcatt tattgatgca ttggttggac acaataaaac cacaattgtt   2460

atcaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                 2492


<210>  3453
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  3453

Met Gly Lys Ser Cys Lys Val Val Val Cys Gly Gln Ala Ser Val Gly 
1               5                   10                  15      


Lys Thr Ser Ile Leu Glu Gln Leu Leu Tyr Gly Asn His Val Val Gly 
            20                  25                  30          


Ser Glu Met Ile Glu Thr Gln Glu Asp Ile Tyr Val Gly Ser Ile Glu 
        35                  40                  45              


Thr Asp Arg Gly Val Arg Glu Gln Val Arg Phe Tyr Asp Thr Arg Gly 
    50                  55                  60                  


Leu Arg Asp Gly Ala Glu Leu Pro Arg His Cys Phe Ser Cys Thr Asp 
65                  70                  75                  80  


Gly Tyr Val Leu Val Tyr Ser Thr Asp Ser Arg Glu Ser Phe Gln Arg 
                85                  90                  95      


Val Glu Leu Leu Lys Lys Glu Ile Asp Lys Ser Lys Asp Lys Lys Glu 
            100                 105                 110         


Val Thr Ile Val Val Leu Gly Asn Lys Cys Asp Leu Gln Glu Gln Arg 
        115                 120                 125             


Arg Val Asp Pro Asp Val Ala Gln His Trp Ala Lys Ser Glu Lys Val 
    130                 135                 140                 


Lys Leu Trp Glu Val Ser Val Ala Asp Arg Arg Ser Leu Leu Glu Pro 
145                 150                 155                 160 


Phe Val Tyr Leu Ala Ser Lys Met Thr Gln Pro Gln Ser Lys Ser Ala 
                165                 170                 175     


Phe Pro Leu Ser Arg Lys Asn Lys Gly Ser Gly Ser Leu Asp Gly 
            180                 185                 190     


<210>  3454
<211>  2023
<212>  DNA
<213>  Homosapiens

<400>  3454
ctcaagggtt ggatggcgga ggctttgtgc ttgtgtgtta ctgaacggac gtttctgggt     60

cctcccatta ctccttgggg aaggagaatt gggaagagaa gtctgaggca gcaagaactg    120

aaggagccaa gcaccggtgg atgatggaag gtcagcgagg ggctccccgg aggagccggg    180

gccgcccggt gtccagggga ggtgccggac acaaagccaa gagagtcaca gggggccggg    240

gcggccggca ggggcccagc cctgccttcc actgtgctct ctgtcagctc caggtcaatt    300

cagagaccca actgaagcag cacatgagca gcaggaggca caaagaccgc ctggccggga    360

agacccccaa gccctccagc cagcacagca agctgcagaa gcacgcagcg ctggctgtga    420

gtatcctcaa gtctaaactg gccttgcaga agcaactcac caagacgttg gcagcccgct    480

tcctgcccag cccgctcccc accgcagcca ctgccatctg tgctctgcca gggcccctgg    540

ccctccgccc tgcccctaca gcagccacta ccctcttccc ggctcccatc ctgggcccag    600

ctctgtttcg caccccagca ggagctgtcc gccctgctac aggacctatc gtccttgccc    660

cttattagcc ctcatgggga ggccagagct gatttcccaa tagccactcc ttgtctcctc    720

ctgtcctgag acaccttggt ttcctacatg ccacagggac tgtgaacagc ttcaggggtc    780

ctgcccgatc cagaaagagc tgggctagtt ttaagggcag ctgccttcca aggactgtcc    840

ccaccctcct ttcgcaggcc ttccagggtt aatcctaggc ttgcctgcat ttcccaccct    900

gacagacccc aaagatctat gcaaaatctc agccccagcc atgtggtgct ctcactttcc    960

tccacccaag acccacatgg ccagactcta ggaatcttag cttctacaag ccatcctctc   1020

ctagccaggg gacgactctc tgacctctat tcctaggctt tggggcttca ctggagatag   1080

ggatggggtc tctagctgca gcaggctcaa ggctgtcagg acaaggtgac catgggagtg   1140

tgacagagga ccatggagga gaaaggggga cccaaaagtc cttcgatcag cagtgctaag   1200

gtggggcaga gccaaggagg tagtggggct ggttctgaaa gcttttgggg gcttcatctg   1260

ctctgaaggg gtgggactaa gagaggaggt gatgttctgg ttgggcccag ggttttgttt   1320

taatcttaag tcttctgggc attcatgggc ccagtctttt tttctgtttg agagtatcat   1380

tctgttgccc aggttagagt gcagtggtgc aatcttggct cactgcatgc agcctctgcc   1440

tccctggttc aagtgatact tgctgataag cccagtctta atattgaggg agtaactcat   1500

ccctcagaag ctcttcttct tagcctttct ctgacttcct gaaccccaac tcttggaggg   1560

cgggtgtggg tctccctcag actatggact cagctaacac cgaacccccc gcagagctcc   1620

caaaggaaga gctttcccct acagcttccc actccaaact ggtcctagca ctaaattcag   1680

ctttcccttc tcccaaccag cccctgccac tgtgaagctg agtgttggga ggcagtctca   1740

catgcactgg caagacccat tttcatgctg tcaatgtcaa tgtcacaaac tcctttccac   1800

tgcagcactg ccccctcccc accccacaat atgggaccct gccagtatcc ccctgtatct   1860

tttttttgtt ttttaaagac atttccaatg ggagaaccag aaaaaggggg aggggaggga   1920

aactttttga taacaattgt ggttttattg tgtccaacca atgcatcaat aaatgaactt   1980

gaagcccaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                     2023


<210>  3455
<211>  174
<212>  PRT
<213>  Homosapiens

<400>  3455

Met Glu Gly Gln Arg Gly Ala Pro Arg Arg Ser Arg Gly Arg Pro Val 
1               5                   10                  15      


Ser Arg Gly Gly Ala Gly His Lys Ala Lys Arg Val Thr Gly Gly Arg 
            20                  25                  30          


Gly Gly Arg Gln Gly Pro Ser Pro Ala Phe His Cys Ala Leu Cys Gln 
        35                  40                  45              


Leu Gln Val Asn Ser Glu Thr Gln Leu Lys Gln His Met Ser Ser Arg 
    50                  55                  60                  


Arg His Lys Asp Arg Leu Ala Gly Lys Thr Pro Lys Pro Ser Ser Gln 
65                  70                  75                  80  


His Ser Lys Leu Gln Lys His Ala Ala Leu Ala Val Ser Ile Leu Lys 
                85                  90                  95      


Ser Lys Leu Ala Leu Gln Lys Gln Leu Thr Lys Thr Leu Ala Ala Arg 
            100                 105                 110         


Phe Leu Pro Ser Pro Leu Pro Thr Ala Ala Thr Ala Ile Cys Ala Leu 
        115                 120                 125             


Pro Gly Pro Leu Ala Leu Arg Pro Ala Pro Thr Ala Ala Thr Thr Leu 
    130                 135                 140                 


Phe Pro Ala Pro Ile Leu Gly Pro Ala Leu Phe Arg Thr Pro Ala Gly 
145                 150                 155                 160 


Ala Val Arg Pro Ala Thr Gly Pro Ile Val Leu Ala Pro Tyr 
                165                 170                 


<210>  3456
<211>  2613
<212>  DNA
<213>  Homosapiens

<400>  3456
agtttcagtt tccatttctg atttctgctc tctgcgctga gcacagcggc accaggctga     60

gctaagcagg gccgccttgg gcaggcctac gtggtggtgc aggcgagacc caggctgggc    120

aaggcgcagt ttcagtttcc atcttgggtc tctgagctga gcagagtggc accaggctga    180

gttaagtggg actgccctgg gcagacctac ctactagagc agaatggagc ttcggtccta    240

ccaatgggag gtgatcatgc ctgccctgga gggcaagaat atcatcatct ggctgcccac    300

gggtgccggg aagacccggg cggctgctta tgtggccaag cggcacctag agactgtgga    360

tggagccaag gtggttgtat tggtcaacag ggtgcacctg gtgacccagc atggtgaaga    420

gttcaggcgc atgctggatg gacgctggac cgtgacaacc ctgagtgggg acatgggacc    480

acgtgctggc tttggccacc tggcccggtg ccatgacctg ctcatctgca cagcagagct    540

tctgcagatg gcactgacca gccccgagga ggaggagcac gtggagctca ctgtcttctc    600

cctgatcgtg gtggatgagt gccaccacac gcacaaggac accgtctaca acgtcatcat    660

gagccagtac ctagaactta aactccagag ggcacagccg ctaccccagg tgctgggtct    720

cacagcctcc ccaggcactg gcggggcctc caaactcgat ggggccatca accacgtcct    780

gcagctctgt gccaacttgg acacgtggtg catcatgtca ccccagaact gctgccccca    840

gctgcaggag cacagccaac agccttgcaa acagtacaac ctctgccaca ggcgcagcca    900

ggatccgttt ggggacttgc tgaagaagct catggaccaa atccatgacc acctggagat    960

gcctgagttg agccggaaat ttgggacgca aatgtatgag cagcaggtgg tgaagctgag   1020

tgaggctgcg gctttggctg ggcttcagga gcaacgggtg tatgcgcttc acctgaggcg   1080

ctacaatgac gcgctgctca tccatgacac cgtccgcgcc gtggatgcct tggctgcgct   1140

gcaggatttc tatcacaggg agcacgtcac taaaacccag atcctgtgtg ccgagcgccg   1200

gctgctggcc ctgttcgatg accgcaagaa tgagctggcc cacttggcaa ctcatggccc   1260

agagaatcca aaactggaga tgctggaaaa gatcctgcaa aggcagttca gtagctctaa   1320

cagccctcgg ggtatcatct tcacccgcac ccgccaaagc gcacactccc tcctgctctg   1380

gctccagcag caacagggcc tgcagactgt ggacatccgg gcccagctac tgattggggc   1440

tgggaacagc agccagagca cccacatgac ccagagggac cagcaagaag tgatccagaa   1500

gttccaagat ggaaccctga accttctggt ggccacgagt gtggcggagg aggggctgga   1560

catcccacat tgcaatgtgg tggtgcgtta tgggctcttg accaatgaaa tctccatggt   1620

ccaggccagg ggccgtgcct gggccgatca gagtgtatac gcgtttgtag caactgaagg   1680

tagccgggag ctgaagcggg agctgatcaa cgaggcgctg gagacgctaa tggagcaggc   1740

agtggctgct gtgcagaaaa tggaccaggc cgagtaccag gccaagatcc gggatctgca   1800

gcaggcagcc ttgaccaagc gggcggccca ggcagcccag cgggagaacc agcggcagca   1860

gttcccagtg gagcacgtgc agctactctg catcaactgc atggtggctg tgggccatgg   1920

cagcgacctg cggaaggtgg agggcaccca ccatgtcaat gtgaacccca acttctcgaa   1980

ctactataat gtctccaggg atcctgtggt catcaacaaa gtcttcaagg actggaagcc   2040

tgggggtgtc atcagctgca ggaactgtgg ggaggtctgg ggtctgcaga tgatctacaa   2100

gtcagtgaag ctgccagtgc tcaaagtccg cagcatgctg ctggagaccc ctcaggggcg   2160

gatccaggcc aaaaagtggt cccgcgtgcc cttctccgtg cctgactttg acttcctgca   2220

gcattgtgcc gagaacttgt cggacctctc cctggactga ccacctcatt gctgcagtgc   2280

ccggtttggg ctgtaggggg cgggagagtc tgcagcagac tccaggcccc tccttcctga   2340

atcatcagct gtgggcatca ggcccaccag ccacacagga gtcctgggca ccctggctta   2400

ggctcccgca atgggaaaac aaccggaggg ccagagctta gtccagacct accttgtacg   2460

cacatagaca ttttcatatg cactggatgg agttagggaa actgaggcaa aagaatttgc   2520

catactgtac tcagaatcac gacattcctt ccctaccaag gccacttcta ttttttgagg   2580

ctcctcataa aaataaatga aaaaatggga tag                                2613


<210>  3457
<211>  678
<212>  PRT
<213>  Homosapiens

<400>  3457

Met Glu Leu Arg Ser Tyr Gln Trp Glu Val Ile Met Pro Ala Leu Glu 
1               5                   10                  15      


Gly Lys Asn Ile Ile Ile Trp Leu Pro Thr Gly Ala Gly Lys Thr Arg 
            20                  25                  30          


Ala Ala Ala Tyr Val Ala Lys Arg His Leu Glu Thr Val Asp Gly Ala 
        35                  40                  45              


Lys Val Val Val Leu Val Asn Arg Val His Leu Val Thr Gln His Gly 
    50                  55                  60                  


Glu Glu Phe Arg Arg Met Leu Asp Gly Arg Trp Thr Val Thr Thr Leu 
65                  70                  75                  80  


Ser Gly Asp Met Gly Pro Arg Ala Gly Phe Gly His Leu Ala Arg Cys 
                85                  90                  95      


His Asp Leu Leu Ile Cys Thr Ala Glu Leu Leu Gln Met Ala Leu Thr 
            100                 105                 110         


Ser Pro Glu Glu Glu Glu His Val Glu Leu Thr Val Phe Ser Leu Ile 
        115                 120                 125             


Val Val Asp Glu Cys His His Thr His Lys Asp Thr Val Tyr Asn Val 
    130                 135                 140                 


Ile Met Ser Gln Tyr Leu Glu Leu Lys Leu Gln Arg Ala Gln Pro Leu 
145                 150                 155                 160 


Pro Gln Val Leu Gly Leu Thr Ala Ser Pro Gly Thr Gly Gly Ala Ser 
                165                 170                 175     


Lys Leu Asp Gly Ala Ile Asn His Val Leu Gln Leu Cys Ala Asn Leu 
            180                 185                 190         


Asp Thr Trp Cys Ile Met Ser Pro Gln Asn Cys Cys Pro Gln Leu Gln 
        195                 200                 205             


Glu His Ser Gln Gln Pro Cys Lys Gln Tyr Asn Leu Cys His Arg Arg 
    210                 215                 220                 


Ser Gln Asp Pro Phe Gly Asp Leu Leu Lys Lys Leu Met Asp Gln Ile 
225                 230                 235                 240 


His Asp His Leu Glu Met Pro Glu Leu Ser Arg Lys Phe Gly Thr Gln 
                245                 250                 255     


Met Tyr Glu Gln Gln Val Val Lys Leu Ser Glu Ala Ala Ala Leu Ala 
            260                 265                 270         


Gly Leu Gln Glu Gln Arg Val Tyr Ala Leu His Leu Arg Arg Tyr Asn 
        275                 280                 285             


Asp Ala Leu Leu Ile His Asp Thr Val Arg Ala Val Asp Ala Leu Ala 
    290                 295                 300                 


Ala Leu Gln Asp Phe Tyr His Arg Glu His Val Thr Lys Thr Gln Ile 
305                 310                 315                 320 


Leu Cys Ala Glu Arg Arg Leu Leu Ala Leu Phe Asp Asp Arg Lys Asn 
                325                 330                 335     


Glu Leu Ala His Leu Ala Thr His Gly Pro Glu Asn Pro Lys Leu Glu 
            340                 345                 350         


Met Leu Glu Lys Ile Leu Gln Arg Gln Phe Ser Ser Ser Asn Ser Pro 
        355                 360                 365             


Arg Gly Ile Ile Phe Thr Arg Thr Arg Gln Ser Ala His Ser Leu Leu 
    370                 375                 380                 


Leu Trp Leu Gln Gln Gln Gln Gly Leu Gln Thr Val Asp Ile Arg Ala 
385                 390                 395                 400 


Gln Leu Leu Ile Gly Ala Gly Asn Ser Ser Gln Ser Thr His Met Thr 
                405                 410                 415     


Gln Arg Asp Gln Gln Glu Val Ile Gln Lys Phe Gln Asp Gly Thr Leu 
            420                 425                 430         


Asn Leu Leu Val Ala Thr Ser Val Ala Glu Glu Gly Leu Asp Ile Pro 
        435                 440                 445             


His Cys Asn Val Val Val Arg Tyr Gly Leu Leu Thr Asn Glu Ile Ser 
    450                 455                 460                 


Met Val Gln Ala Arg Gly Arg Ala Trp Ala Asp Gln Ser Val Tyr Ala 
465                 470                 475                 480 


Phe Val Ala Thr Glu Gly Ser Arg Glu Leu Lys Arg Glu Leu Ile Asn 
                485                 490                 495     


Glu Ala Leu Glu Thr Leu Met Glu Gln Ala Val Ala Ala Val Gln Lys 
            500                 505                 510         


Met Asp Gln Ala Glu Tyr Gln Ala Lys Ile Arg Asp Leu Gln Gln Ala 
        515                 520                 525             


Ala Leu Thr Lys Arg Ala Ala Gln Ala Ala Gln Arg Glu Asn Gln Arg 
    530                 535                 540                 


Gln Gln Phe Pro Val Glu His Val Gln Leu Leu Cys Ile Asn Cys Met 
545                 550                 555                 560 


Val Ala Val Gly His Gly Ser Asp Leu Arg Lys Val Glu Gly Thr His 
                565                 570                 575     


His Val Asn Val Asn Pro Asn Phe Ser Asn Tyr Tyr Asn Val Ser Arg 
            580                 585                 590         


Asp Pro Val Val Ile Asn Lys Val Phe Lys Asp Trp Lys Pro Gly Gly 
        595                 600                 605             


Val Ile Ser Cys Arg Asn Cys Gly Glu Val Trp Gly Leu Gln Met Ile 
    610                 615                 620                 


Tyr Lys Ser Val Lys Leu Pro Val Leu Lys Val Arg Ser Met Leu Leu 
625                 630                 635                 640 


Glu Thr Pro Gln Gly Arg Ile Gln Ala Lys Lys Trp Ser Arg Val Pro 
                645                 650                 655     


Phe Ser Val Pro Asp Phe Asp Phe Leu Gln His Cys Ala Glu Asn Leu 
            660                 665                 670         


Ser Asp Leu Ser Leu Asp 
        675             


<210>  3458
<211>  3074
<212>  DNA
<213>  Homosapiens

<400>  3458
ccgctctccg ctgcggggga ggccatggcg gaaccttccc aggccccgac cccggccccg     60

gctgcgcagc cccggcccct tcagtcccca gcccctgccc caactccgac tcctgcaccc    120

agcccggctt cagccccgat tccgactccc accccggcac cagcccctgc cccagctgca    180

gccccagccg gcagcacagg gactgggggg cccggggtag gaagtggggg ggccgggagc    240

gggggggatc cggctcggcc tggcctgagc cagcagcagc gcgccagtca gaggaaggcg    300

caagtccggg ggctgccccg cgccaagaag cttgagaagc taggggtctt ctcggcttgc    360

aaggccaatg gaacctgtaa gtgtaatggc tggaaaaacc ccaagccccc cactgcaccc    420

cgcatagatc tgcagcagcc agctgccaac ctgagtgagc tgtgccgcag ttgtgagcac    480

cccttggctg accacgtatc ccacttggag aatgtgtcag aggatgagat aaaccgactg    540

ctggggatgg tggtggatgt ggagaatctc ttcatgtctg ttcacaagga agaggacaca    600

gacaccaagc aggtctattt ctacctcttc aagctactgc ggaaatgcat cctgcagatg    660

acccggcctg tggtggaggg gtccctgggc agccctccat ttgagaaacc taatattgag    720

cagggtgtgc tgaactttgt gcagtacaag tttagtcacc tggctccccg ggagcggcag    780

acgatgttcg agctctcaaa gatgttcttg ctctgcctta actactggga gcttgagaca    840

cctgcccagt ttcggcagag gtctcaggct gaggacgtgg ctacctacaa ggtcaattac    900

accagatggc tctgttactg ccacgtgccc cagagctgtg atagcctccc ccgctacgaa    960

accactcatg tctttgggcg aagccttctc cggtccattt tcaccgttac ccgccggcag   1020

ctgctggaaa agttccgagt ggagaaggac aaattggtgc ccgagaagag gaccctcatc   1080

ctcactcact tccccaaatt cctgtccatg ctggaggagg agatctatgg ggcaaactct   1140

ccaatctggg agtcaggctt caccatgcca ccctcagagg ggacacagct ggttccccgg   1200

ccagcttcag tcagtgcagc ggttgttccc agcaccccca tcttcagccc cagcatgggt   1260

gggggcagca acagctccct gagtctggat tctgcagggg ccgagcctat gccaggcgag   1320

aagaggacgc tcccagagaa cctgaccctg gaggatgcca agcggctccg tgtgatgggt   1380

gacatcccca tggagctggt caatgaggtc atgctgacca tcactgaccc tgctgccatg   1440

ctggggcctg agacgagcct gctttcggcc aatgcggccc gggatgagac agcccgcctg   1500

gaggagcgcc gcggcatcat cgagttccat gtcatcggca actcactgac gcccaaggcc   1560

aaccggcggg tgttgctgtg gctcgtgggg ctgcagaatg tcttttccca ccagctgccg   1620

cgcatgccta aggagtatat cgcccgcctc gtctttgacc cgaagcacaa gactctggcc   1680

ttgatcaagg atgggcgggt catcggtggc atctgcttcc gcatgtttcc cacccagggc   1740

ttcacggaga ttgtcttctg tgctgtcacc tcgaatgagc aggtcaaggg ttatgggacc   1800

cacctgatga accacctgaa ggagtatcac atcaagcaca acattctcta cttcctcacc   1860

tacgccgacg agtacgccat cggctacttc aaaaagcagg gtttctccaa ggacatcaag   1920

gtgcccaaga gccgctacct gggctacatc aaggactacg agggagcgac gctgatggag   1980

tgtgagctga atccccgcat cccctacacg gagctgtccc acatcatcaa gaagcagaaa   2040

gagatcatca agaagctgat tgagcgcaaa caggcccaga tccgcaaggt ctacccgggg   2100

ctcagctgct tcaaggaggg cgtgaggcag atccctgtgg agagcgttcc tggcattcga   2160

gagacaggct ggaagccatt ggggaaggag aaggggaagg agctgaagga ccccgaccag   2220

ctctacacaa ccctcaaaaa cctgctggcc caaatcaagt ctcaccccag tgcctggccc   2280

ttcatggagc ctgtgaagaa gtcggaggcc cctgactact acgaggtcat ccgcttcccc   2340

attgacctga agaccatgac tgagcggctg cgaagccgct actacgtgac ccggaagctc   2400

tttgtggccg acctgcagcg ggtcatcgcc aactgtcgcg agtacaaccc cccggacagc   2460

gagtactgcc gctgtgccag cgccctggag aagttcttct acttcaagct caaggaggga   2520

ggcctcattg acaagtaggc ccatctttgg gccgcagccc tgacctggaa tgtctccacc   2580

tcggattctg atctgatcct tagggggtgc cctggcccca cggacccgac tcagcttgag   2640

acactccagc caagggtcct ccggacccga tcctgcagct ctttctggac cttcaggcac   2700

ccccaagcgt gcagctctgt cccagccttc actgtgtgtg agaggtctcc tgggttgggg   2760

cccagcccct ctagagtagc tggtggccag ggatgaacct tgcccagccg tggtggcccc   2820

caggcctggt ccccaagagc tttggaggct tggattcctg ggcctggccc aggtggctgt   2880

ttccctgagg accagaactg ctcattttag cttgagtgat ggcttcaggg gttggaagtt   2940

cagcccaaac tgaagggggc catgccttgt ccagcactgt tctgtcagtc tcccccaggg   3000

gtggggggta tggggaccat tcattccctg gcattaatcc cttagaggga ataataaagc   3060

tttttatttc tctg                                                     3074


<210>  3459
<211>  837
<212>  PRT
<213>  Homosapiens

<400>  3459

Met Ala Glu Pro Ser Gln Ala Pro Thr Pro Ala Pro Ala Ala Gln Pro 
1               5                   10                  15      


Arg Pro Leu Gln Ser Pro Ala Pro Ala Pro Thr Pro Thr Pro Ala Pro 
            20                  25                  30          


Ser Pro Ala Ser Ala Pro Ile Pro Thr Pro Thr Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Ala Ala Pro Ala Gly Ser Thr Gly Thr Gly Gly Pro Gly 
    50                  55                  60                  


Val Gly Ser Gly Gly Ala Gly Ser Gly Gly Asp Pro Ala Arg Pro Gly 
65                  70                  75                  80  


Leu Ser Gln Gln Gln Arg Ala Ser Gln Arg Lys Ala Gln Val Arg Gly 
                85                  90                  95      


Leu Pro Arg Ala Lys Lys Leu Glu Lys Leu Gly Val Phe Ser Ala Cys 
            100                 105                 110         


Lys Ala Asn Gly Thr Cys Lys Cys Asn Gly Trp Lys Asn Pro Lys Pro 
        115                 120                 125             


Pro Thr Ala Pro Arg Ile Asp Leu Gln Gln Pro Ala Ala Asn Leu Ser 
    130                 135                 140                 


Glu Leu Cys Arg Ser Cys Glu His Pro Leu Ala Asp His Val Ser His 
145                 150                 155                 160 


Leu Glu Asn Val Ser Glu Asp Glu Ile Asn Arg Leu Leu Gly Met Val 
                165                 170                 175     


Val Asp Val Glu Asn Leu Phe Met Ser Val His Lys Glu Glu Asp Thr 
            180                 185                 190         


Asp Thr Lys Gln Val Tyr Phe Tyr Leu Phe Lys Leu Leu Arg Lys Cys 
        195                 200                 205             


Ile Leu Gln Met Thr Arg Pro Val Val Glu Gly Ser Leu Gly Ser Pro 
    210                 215                 220                 


Pro Phe Glu Lys Pro Asn Ile Glu Gln Gly Val Leu Asn Phe Val Gln 
225                 230                 235                 240 


Tyr Lys Phe Ser His Leu Ala Pro Arg Glu Arg Gln Thr Met Phe Glu 
                245                 250                 255     


Leu Ser Lys Met Phe Leu Leu Cys Leu Asn Tyr Trp Glu Leu Glu Thr 
            260                 265                 270         


Pro Ala Gln Phe Arg Gln Arg Ser Gln Ala Glu Asp Val Ala Thr Tyr 
        275                 280                 285             


Lys Val Asn Tyr Thr Arg Trp Leu Cys Tyr Cys His Val Pro Gln Ser 
    290                 295                 300                 


Cys Asp Ser Leu Pro Arg Tyr Glu Thr Thr His Val Phe Gly Arg Ser 
305                 310                 315                 320 


Leu Leu Arg Ser Ile Phe Thr Val Thr Arg Arg Gln Leu Leu Glu Lys 
                325                 330                 335     


Phe Arg Val Glu Lys Asp Lys Leu Val Pro Glu Lys Arg Thr Leu Ile 
            340                 345                 350         


Leu Thr His Phe Pro Lys Phe Leu Ser Met Leu Glu Glu Glu Ile Tyr 
        355                 360                 365             


Gly Ala Asn Ser Pro Ile Trp Glu Ser Gly Phe Thr Met Pro Pro Ser 
    370                 375                 380                 


Glu Gly Thr Gln Leu Val Pro Arg Pro Ala Ser Val Ser Ala Ala Val 
385                 390                 395                 400 


Val Pro Ser Thr Pro Ile Phe Ser Pro Ser Met Gly Gly Gly Ser Asn 
                405                 410                 415     


Ser Ser Leu Ser Leu Asp Ser Ala Gly Ala Glu Pro Met Pro Gly Glu 
            420                 425                 430         


Lys Arg Thr Leu Pro Glu Asn Leu Thr Leu Glu Asp Ala Lys Arg Leu 
        435                 440                 445             


Arg Val Met Gly Asp Ile Pro Met Glu Leu Val Asn Glu Val Met Leu 
    450                 455                 460                 


Thr Ile Thr Asp Pro Ala Ala Met Leu Gly Pro Glu Thr Ser Leu Leu 
465                 470                 475                 480 


Ser Ala Asn Ala Ala Arg Asp Glu Thr Ala Arg Leu Glu Glu Arg Arg 
                485                 490                 495     


Gly Ile Ile Glu Phe His Val Ile Gly Asn Ser Leu Thr Pro Lys Ala 
            500                 505                 510         


Asn Arg Arg Val Leu Leu Trp Leu Val Gly Leu Gln Asn Val Phe Ser 
        515                 520                 525             


His Gln Leu Pro Arg Met Pro Lys Glu Tyr Ile Ala Arg Leu Val Phe 
    530                 535                 540                 


Asp Pro Lys His Lys Thr Leu Ala Leu Ile Lys Asp Gly Arg Val Ile 
545                 550                 555                 560 


Gly Gly Ile Cys Phe Arg Met Phe Pro Thr Gln Gly Phe Thr Glu Ile 
                565                 570                 575     


Val Phe Cys Ala Val Thr Ser Asn Glu Gln Val Lys Gly Tyr Gly Thr 
            580                 585                 590         


His Leu Met Asn His Leu Lys Glu Tyr His Ile Lys His Asn Ile Leu 
        595                 600                 605             


Tyr Phe Leu Thr Tyr Ala Asp Glu Tyr Ala Ile Gly Tyr Phe Lys Lys 
    610                 615                 620                 


Gln Gly Phe Ser Lys Asp Ile Lys Val Pro Lys Ser Arg Tyr Leu Gly 
625                 630                 635                 640 


Tyr Ile Lys Asp Tyr Glu Gly Ala Thr Leu Met Glu Cys Glu Leu Asn 
                645                 650                 655     


Pro Arg Ile Pro Tyr Thr Glu Leu Ser His Ile Ile Lys Lys Gln Lys 
            660                 665                 670         


Glu Ile Ile Lys Lys Leu Ile Glu Arg Lys Gln Ala Gln Ile Arg Lys 
        675                 680                 685             


Val Tyr Pro Gly Leu Ser Cys Phe Lys Glu Gly Val Arg Gln Ile Pro 
    690                 695                 700                 


Val Glu Ser Val Pro Gly Ile Arg Glu Thr Gly Trp Lys Pro Leu Gly 
705                 710                 715                 720 


Lys Glu Lys Gly Lys Glu Leu Lys Asp Pro Asp Gln Leu Tyr Thr Thr 
                725                 730                 735     


Leu Lys Asn Leu Leu Ala Gln Ile Lys Ser His Pro Ser Ala Trp Pro 
            740                 745                 750         


Phe Met Glu Pro Val Lys Lys Ser Glu Ala Pro Asp Tyr Tyr Glu Val 
        755                 760                 765             


Ile Arg Phe Pro Ile Asp Leu Lys Thr Met Thr Glu Arg Leu Arg Ser 
    770                 775                 780                 


Arg Tyr Tyr Val Thr Arg Lys Leu Phe Val Ala Asp Leu Gln Arg Val 
785                 790                 795                 800 


Ile Ala Asn Cys Arg Glu Tyr Asn Pro Pro Asp Ser Glu Tyr Cys Arg 
                805                 810                 815     


Cys Ala Ser Ala Leu Glu Lys Phe Phe Tyr Phe Lys Leu Lys Glu Gly 
            820                 825                 830         


Gly Leu Ile Asp Lys 
        835         


<210>  3460
<211>  480
<212>  DNA
<213>  Homosapiens

<400>  3460
atgcagagag tcggtaacac cttctccaac gagagccggg tggcatcccg gtgtcccagc     60

gtgggccttg ctgaacggaa ccgggtggcc acaatgccgg tgcggctgct cagggacagt    120

ccagcggctc aggaggacaa tgaccatgcc agagacggtt tccaaatgaa gctggatgcc    180

cacggcttcg ccccggagga actggtggtg caggtggatg gccaatggct gatggtgacc    240

ggacagcagc aactggacgt cagggacccg gaaagggtca gttaccgcat gtcacagaag    300

gtgcaccgga aaatgctccc gtccaacctg agtcctaccg ccatgacctg ctgcctgacc    360

ccctccgggc agctgtgggt cagaggccag tgtgtggcgc tggccctccc tgaagcccaa    420

acaggaccgt ccccgagact cgggagcctc ggctctaagg cttccaacct gacccggtaa    480


<210>  3461
<211>  159
<212>  PRT
<213>  Homosapiens

<400>  3461

Met Gln Arg Val Gly Asn Thr Phe Ser Asn Glu Ser Arg Val Ala Ser 
1               5                   10                  15      


Arg Cys Pro Ser Val Gly Leu Ala Glu Arg Asn Arg Val Ala Thr Met 
            20                  25                  30          


Pro Val Arg Leu Leu Arg Asp Ser Pro Ala Ala Gln Glu Asp Asn Asp 
        35                  40                  45              


His Ala Arg Asp Gly Phe Gln Met Lys Leu Asp Ala His Gly Phe Ala 
    50                  55                  60                  


Pro Glu Glu Leu Val Val Gln Val Asp Gly Gln Trp Leu Met Val Thr 
65                  70                  75                  80  


Gly Gln Gln Gln Leu Asp Val Arg Asp Pro Glu Arg Val Ser Tyr Arg 
                85                  90                  95      


Met Ser Gln Lys Val His Arg Lys Met Leu Pro Ser Asn Leu Ser Pro 
            100                 105                 110         


Thr Ala Met Thr Cys Cys Leu Thr Pro Ser Gly Gln Leu Trp Val Arg 
        115                 120                 125             


Gly Gln Cys Val Ala Leu Ala Leu Pro Glu Ala Gln Thr Gly Pro Ser 
    130                 135                 140                 


Pro Arg Leu Gly Ser Leu Gly Ser Lys Ala Ser Asn Leu Thr Arg 
145                 150                 155                 


<210>  3462
<211>  1674
<212>  DNA
<213>  Homosapiens

<400>  3462
gagcggctga aaggcggaag tggaggccgg agcctgggac accgccggcg gggagagaag     60

cggatcccgt ccgagccccg gccccaagta acgccgccgc cccggagccg ccttggaggt    120

ccccctcccc actaagtgcc tctttgcata gcaccagtcc ccacccgcac gctctctgga    180

ccactacagc tggacgggca atggcgggtc ggggaggcgc agcacgaccc aatggaccag    240

ctgctgggaa caagatctgt caatttaagc tggttctgct gggggagtct gcggtaggca    300

aatccagcct cgtcctccgc tttgtcaagg gacagtttca cgagtaccag gagagcacaa    360

ttggagcggc cttcctcaca cagactgtct gcctggatga cacaacagtc aagtttgaga    420

tctgggacac agctggacag gagcggtatc acagcctggc ccccatgtac tatcgggggg    480

cccaggctgc catcgtggtc tatgacatca ccaacacaga tacatttgca cgggccaaga    540

actgggtgaa ggagctacag aggcaggcca gccccaacat cgtcattgca ctcgcgggta    600

acaaggcaga cctggccagc aagagagccg tggaattcca ggaagcacaa gcctatgcag    660

acgacaacag tttgctgttc atggagacat cagcaaagac tgcaatgaac gtgaacgaaa    720

tcttcatggc aatagctaag aagcttccca agaacgagcc ccagaatgca actggtgctc    780

caggccgaaa ccgaggtgtg gacctccagg agaacaaccc agccagccgg agccagtgct    840

gcagcaactg agcccccctt gcctgcccgc tgcccccgcc tcctccgcct gaatgacccg    900

actggaatcc actctaacca atcgcactta acgactcggg ccaccactgg gggggcaggg    960

ggaggggtcc accatgattt ctccatataa ttttgatcat aggccggagt gagtcattcc   1020

acctgcacct ttctgtacaa atactaattc aattttaagt cttaagtcac ttttttaata   1080

tatatgatct tctgctcttc ccacttcctc ccctttctac tgctctccca ttttcccttg   1140

ctgggagtag ccacatgctc ttgcccccca acccttgtat atggggacag tggggtcagt   1200

gcagctaccc tttctttccc tcctgcggaa cagcggaccc agcaagagca tccacatcct   1260

cactttgttc ggagtggtct ttggtttggg cggtggggca gaccttggga aggggcttag   1320

gaagggagag gcagctcttc cttcagctgg ctctcatcag gctgcagccc cctccccgct   1380

cccacctccc tgctgggaaa ccacagcatt atcacagcat tattgtgaca gccacgaacc   1440

cattgcccac aacccctcca ccctcggtca ccccaacctc tggctctgag ccctgttctg   1500

accaaatcat gatgatgagt atttgggggt gggtgggtaa gggggggagt gggaggggac   1560

ggaaccaact ttttctgtat tttgtattgt atgttttctt caacatgtaa ccaatcagta   1620

tcttgtcaat atagtcagcc gatcgatcga cctcaaaaaa aaaaaaaaaa aaaa         1674


<210>  3463
<211>  216
<212>  PRT
<213>  Homosapiens

<400>  3463

Met Ala Gly Arg Gly Gly Ala Ala Arg Pro Asn Gly Pro Ala Ala Gly 
1               5                   10                  15      


Asn Lys Ile Cys Gln Phe Lys Leu Val Leu Leu Gly Glu Ser Ala Val 
            20                  25                  30          


Gly Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Gln Phe His Glu 
        35                  40                  45              


Tyr Gln Glu Ser Thr Ile Gly Ala Ala Phe Leu Thr Gln Thr Val Cys 
    50                  55                  60                  


Leu Asp Asp Thr Thr Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln 
65                  70                  75                  80  


Glu Arg Tyr His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ala Gln Ala 
                85                  90                  95      


Ala Ile Val Val Tyr Asp Ile Thr Asn Thr Asp Thr Phe Ala Arg Ala 
            100                 105                 110         


Lys Asn Trp Val Lys Glu Leu Gln Arg Gln Ala Ser Pro Asn Ile Val 
        115                 120                 125             


Ile Ala Leu Ala Gly Asn Lys Ala Asp Leu Ala Ser Lys Arg Ala Val 
    130                 135                 140                 


Glu Phe Gln Glu Ala Gln Ala Tyr Ala Asp Asp Asn Ser Leu Leu Phe 
145                 150                 155                 160 


Met Glu Thr Ser Ala Lys Thr Ala Met Asn Val Asn Glu Ile Phe Met 
                165                 170                 175     


Ala Ile Ala Lys Lys Leu Pro Lys Asn Glu Pro Gln Asn Ala Thr Gly 
            180                 185                 190         


Ala Pro Gly Arg Asn Arg Gly Val Asp Leu Gln Glu Asn Asn Pro Ala 
        195                 200                 205             


Ser Arg Ser Gln Cys Cys Ser Asn 
    210                 215     


<210>  3464
<211>  1791
<212>  DNA
<213>  Homosapiens

<400>  3464
gagcggctga aaggcggaag tggaggccgg agcctgggac accgccggcg gggagagaag     60

cggatcccgt ccgagccccg gccccaagta acgccgccgc cccggagccg ccagtctcgc    120

tctctcgcca ggccggagtg cagtggcact atctcagctc agtgcaacct ctgcctcccg    180

ggttcaagcg attctcctgc ctcagcctcc cgagtagctg ggactacagt tggaggtccc    240

cctccccact aagtgcctct ttgcatagca ccagtcccca cccgcacgct ctctggacca    300

ctacagctgg acgggcaatg gcgggtcggg gaggcgcagc acgacccaat ggaccagctg    360

ctgggaacaa gatctgtcaa tttaagctgg ttctgctggg ggagtctgcg gtaggcaaat    420

ccagcctcgt cctccgcttt gtcaagggac agtttcacga gtaccaggag agcacaattg    480

gagcggcctt cctcacacag actgtctgcc tggatgacac aacagtcaag tttgagatct    540

gggacacagc tggacaggag cggtatcaca gcctggcccc catgtactat cggggggccc    600

aggctgccat cgtggtctat gacatcacca acacagatac atttgcacgg gccaagaact    660

gggtgaagga gctacagagg caggccagcc ccaacatcgt cattgcactc gcgggtaaca    720

aggcagacct ggccagcaag agagccgtgg aattccagga agcacaagcc tatgcagacg    780

acaacagttt gctgttcatg gagacatcag caaagactgc aatgaacgtg aacgaaatct    840

tcatggcaat agctaagaag cttcccaaga acgagcccca gaatgcaact ggtgctccag    900

gccgaaaccg aggtgtggac ctccaggaga acaacccagc cagccggagc cagtgctgca    960

gcaactgagc cccccttgcc tgcccgctgc ccccgcctcc tccgcctgaa tgacccgact   1020

ggaatccact ctaaccaatc gcacttaacg actcgggcca ccactggggg ggcaggggga   1080

ggggtccacc atgatttctc catataattt tgatcatagg ccggagtgag tcattccacc   1140

tgcacctttc tgtacaaata ctaattcaat tttaagtctt aagtcacttt tttaatatat   1200

atgatcttct gctcttccca cttcctcccc tttctactgc tctcccattt tcccttgctg   1260

ggagtagcca catgctcttg ccccccaacc cttgtatatg gggacagtgg ggtcagtgca   1320

gctacccttt ctttccctcc tgcggaacag cggacccagc aagagcatcc acatcctcac   1380

tttgttcgga gtggtctttg gtttgggcgg tggggcagac cttgggaagg ggcttaggaa   1440

gggagaggca gctcttcctt cagctggctc tcatcaggct gcagccccct ccccgctccc   1500

acctccctgc tgggaaacca cagcattatc acagcattat tgtgacagcc acgaacccat   1560

tgcccacaac ccctccaccc tcggtcaccc caacctctgg ctctgagccc tgttctgacc   1620

aaatcatgat gatgagtatt tgggggtggg tgggtaaggg ggggagtggg aggggacgga   1680

accaactttt tctgtatttt gtattgtatg ttttcttcaa catgtaacca atcagtatct   1740

tgtcaatata gtcagccgat cgatcgacct caaaaaaaaa aaaaaaaaaa a            1791


<210>  3465
<211>  216
<212>  PRT
<213>  Homosapiens

<400>  3465

Met Ala Gly Arg Gly Gly Ala Ala Arg Pro Asn Gly Pro Ala Ala Gly 
1               5                   10                  15      


Asn Lys Ile Cys Gln Phe Lys Leu Val Leu Leu Gly Glu Ser Ala Val 
            20                  25                  30          


Gly Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Gln Phe His Glu 
        35                  40                  45              


Tyr Gln Glu Ser Thr Ile Gly Ala Ala Phe Leu Thr Gln Thr Val Cys 
    50                  55                  60                  


Leu Asp Asp Thr Thr Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln 
65                  70                  75                  80  


Glu Arg Tyr His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ala Gln Ala 
                85                  90                  95      


Ala Ile Val Val Tyr Asp Ile Thr Asn Thr Asp Thr Phe Ala Arg Ala 
            100                 105                 110         


Lys Asn Trp Val Lys Glu Leu Gln Arg Gln Ala Ser Pro Asn Ile Val 
        115                 120                 125             


Ile Ala Leu Ala Gly Asn Lys Ala Asp Leu Ala Ser Lys Arg Ala Val 
    130                 135                 140                 


Glu Phe Gln Glu Ala Gln Ala Tyr Ala Asp Asp Asn Ser Leu Leu Phe 
145                 150                 155                 160 


Met Glu Thr Ser Ala Lys Thr Ala Met Asn Val Asn Glu Ile Phe Met 
                165                 170                 175     


Ala Ile Ala Lys Lys Leu Pro Lys Asn Glu Pro Gln Asn Ala Thr Gly 
            180                 185                 190         


Ala Pro Gly Arg Asn Arg Gly Val Asp Leu Gln Glu Asn Asn Pro Ala 
        195                 200                 205             


Ser Arg Ser Gln Cys Cys Ser Asn 
    210                 215     


<210>  3466
<211>  3920
<212>  DNA
<213>  Homosapiens

<400>  3466
gtgggccgct cccctctggg aggagggctg cccagagggg tgcgggtgtc gctagcggcc     60

cctccccgtg tggggccacg tggcgggtgc gggccgagcc cgaggggaag aacctggccc    120

gtggggaggt gggggggacc gaaacggcgc tgagccgagc cgagagctac ggggttcgga    180

gcagaggcag cggcagcggc agcggcagta agagggaggg gaggaggcag gagggcgcat    240

ggggcgcccc ggcccctccg acagcgcgcc ccctccggcc cggccgcgct gaaagctccc    300

cagcgccgcg ccttgaaccc acgccccggg gccatgccgg tcatgaaggg gttgctggcc    360

ccgcaaaaca ccttcctgga caccatcgcc acccgttttg acggaacgca cagcaacttc    420

ctgctggcca acgcacaggg cacacggggc tttcccatcg tctactgctc cgacggcttc    480

tgcgagctca caggctacgg tcgcaccgag gtcatgcaga agacctgcag ctgccgtttc    540

ctctacggcc cagagaccag tgagccagcc ctgcagcgtc tgcacaaagc cctggagggc    600

caccaggagc accgggctga aatctgcttc taccgcaagg atggctcagc cttttggtgc    660

ctcctggaca tgatgcccat caagaatgag atgggggagg tcgtgctgtt cctcttttcc    720

ttcaaggata tcactcagag tggaagccca ggacttggcc cccaaggagg ccgcggggac    780

agtaatcacg aaaactccct tggtagaagg ggagccacct ggaaatttcg gtctgccaga    840

agacggagcc gtactgtcct acaccgactg accggccact ttggccgccg gggccaggga    900

ggcatgaagg ccaataataa cgtgtttgag ccaaagccat cagtgcccga gtacaaggtg    960

gcctccgtgg gggggtctcg ctgcctcctc ctccactaca gcgtctccaa ggccatctgg   1020

gacggcctta tcctccttgc caccttctac gttgcggtca ccgtccccta caatgtctgt   1080

ttctcgggtg acgatgacac ccccatcact tcgcgacaca cccttgtcag cgacatcgcc   1140

gtggaaatgc tcttcatcct agatatcatc ctgaacttcc gcaccaccta tgtgtcccag   1200

tccggccagg taatctctgc tcctcgttcc attggcctcc actacctggc cacctggttc   1260

ttcatcgacc ttattgctgc tctgcccttt gacctgcttt acatcttcaa catcaccgtg   1320

acctcgctgg tgcacctact gaagacagtg cggctgttgc ggctgctgcg gctgctgcag   1380

aagctggagc ggtactctca gtgcagtgct gtggtgctca cgctgctcat gtcggtcttt   1440

gcgctccttg cccactggat ggcctgcatc tggtatgtca tcgggcgccg ggagatggag   1500

gccaatgacc cgctgctctg ggacattggc tggttgcatg agttgggcaa gcgtctggag   1560

gtgccctatg tcaatggctc ggtgggcggc ccatcacggc gcagcgccta catcgcggca   1620

ctgtacttca ctctaagcag cctcaccagt gtgggctttg gcaacgtgtg tgccaacacc   1680

gacgcggaga agatcttctc catctgcacg atgctcatag gcgccctgat gcacgctgtg   1740

gtgttcggga acgtgacagc catcatccag cgcatgtact cgcgccgctc gctctaccac   1800

agccgcatga aggacctcaa ggacttcatc cgtgtgcacc gcctgccgcg gccgctcaag   1860

cagcgcatgc tcgaatactt ccagaccacg tgggccgtca acagcggcat cgacgccaac   1920

gagttactgc gtgacttccc agacgagctg agagctgaca ttgctatgca cctgaatcgg   1980

gagatcctgc agctgccgtt gttcggggca gcgagcaggg gctgcctgcg ggccctatcg   2040

ctgcacatca agacctcgtt ctgcgctccg ggcgagtacc tgttgcgccg tggggatgcc   2100

ctgcaggcac attactatgt ctgctccggc tcgcttgagg tgctccgaga caacatggtg   2160

ctggccatcc tggggaaggg ggacctgatt ggagcagata tccctgagcc ggggcaggag   2220

cctgggttgg gagcagaccc aaacttcgtg ctaaagacca gtgctgatgt gaaagctctg   2280

acctactgtg gcctgcagca gctgagcagc cgagggctgg ctgaggtcct gaggctctat   2340

cctgagtatg gggctgcctt ccgggctggc ctgccccggg acctcacctt caacctgcgc   2400

cagggctctg acaccagtgg cctcagccgc ttttcccgat cccctcgcct ctcccagccc   2460

cgctcagaaa gcctcggctc ctcctcagac aagacgctgc catccatcac agaggccgag   2520

agtggcgcgg agcctggggg tggtcccagg ccccgacggc ccctcctgct gcccaacctc   2580

agcccagcac ggcctcgggg ctccctggtc agccttttgg gcgaggagct gcccccattc   2640

tcagcccttg tctcctctcc ttccttatcc ccatccctgt cccctgccct ggctggccag   2700

ggccacagtg cctcccctca cggccccccc aggtgctctg ctgcctggaa gccccctcag   2760

cttctcattc ccccactggg aacctttgga cctccggacc tcagtccccg gatagtggat   2820

ggcattgagg actctggcag cacagctgag gccccttcat tccgattcag caggaggcct   2880

gaactgccaa ggccccgctc ccaggcgccc cctacaggga ccaggcccag cccagaattg   2940

gccagtgagg ctgaggaggt gaaggaaaag gtttgccggc tgaaccagga gatctctcgt   3000

ctcaatcagg aggtgtctca gcttagccgg gagctgcggc acatcatggg cctgctgcag   3060

gccaggctgg gtcccccagg ccacccagca ggctccgctt ggaccccaga ccctccttgt   3120

ccacagctga ggccaccatg cctctctcct tgtgcgtcca gaccaccacc cagcctccag   3180

gatactacgc ttgctgaagt tcactgccca gccagtgtgg ggaccatgga gacagggact   3240

gcgctcctgg acttgagacc ttccatattg cccccctacc cctcagagcc tgaccctctg   3300

ggaccctctc cagtgccaga ggcctcaccc ccaaccccaa gcctcttgag gcacagtttc   3360

cagtccaggt cagacacgtt ccactgaccc tggcccaggg cccaggcctg tctggggtgg   3420

gcgctgccgc tcaccactca gggaggacct gggccccttg gcttcctgcc ttggggtcag   3480

cagccaccag ctggcctggt tggctctgga tttctggact ttttaatgaa gcgtggttac   3540

ctctgacgct attccctttt ccaagccttc cccaacctcc ccctctgtga ggggagccac   3600

ctgagggctg tggaacccag caggcatgag atgaaccgca gtgcccattg ggctgggcag   3660

atgagatcct actttctccc caggacctgg aggcaggctg tctctcaagg tggtcttttc   3720

tgctgctagc aactcaaaaa tcccaacagc actccctatc ctttccctga ccccagaccg   3780

ctgccaagcc tgttctcccc cattacaaca tggtctcact cagggcctgg actgctccaa   3840

aactcgccca ggtctccagc tctcctctac cccccaacac cctgggctca cttttggata   3900

ggaaataaac tctttatttt                                               3920


<210>  3467
<211>  1017
<212>  PRT
<213>  Homosapiens

<400>  3467

Met Pro Val Met Lys Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Leu Leu Ala 
            20                  25                  30          


Asn Ala Gln Gly Thr Arg Gly Phe Pro Ile Val Tyr Cys Ser Asp Gly 
        35                  40                  45              


Phe Cys Glu Leu Thr Gly Tyr Gly Arg Thr Glu Val Met Gln Lys Thr 
    50                  55                  60                  


Cys Ser Cys Arg Phe Leu Tyr Gly Pro Glu Thr Ser Glu Pro Ala Leu 
65                  70                  75                  80  


Gln Arg Leu His Lys Ala Leu Glu Gly His Gln Glu His Arg Ala Glu 
                85                  90                  95      


Ile Cys Phe Tyr Arg Lys Asp Gly Ser Ala Phe Trp Cys Leu Leu Asp 
            100                 105                 110         


Met Met Pro Ile Lys Asn Glu Met Gly Glu Val Val Leu Phe Leu Phe 
        115                 120                 125             


Ser Phe Lys Asp Ile Thr Gln Ser Gly Ser Pro Gly Leu Gly Pro Gln 
    130                 135                 140                 


Gly Gly Arg Gly Asp Ser Asn His Glu Asn Ser Leu Gly Arg Arg Gly 
145                 150                 155                 160 


Ala Thr Trp Lys Phe Arg Ser Ala Arg Arg Arg Ser Arg Thr Val Leu 
                165                 170                 175     


His Arg Leu Thr Gly His Phe Gly Arg Arg Gly Gln Gly Gly Met Lys 
            180                 185                 190         


Ala Asn Asn Asn Val Phe Glu Pro Lys Pro Ser Val Pro Glu Tyr Lys 
        195                 200                 205             


Val Ala Ser Val Gly Gly Ser Arg Cys Leu Leu Leu His Tyr Ser Val 
    210                 215                 220                 


Ser Lys Ala Ile Trp Asp Gly Leu Ile Leu Leu Ala Thr Phe Tyr Val 
225                 230                 235                 240 


Ala Val Thr Val Pro Tyr Asn Val Cys Phe Ser Gly Asp Asp Asp Thr 
                245                 250                 255     


Pro Ile Thr Ser Arg His Thr Leu Val Ser Asp Ile Ala Val Glu Met 
            260                 265                 270         


Leu Phe Ile Leu Asp Ile Ile Leu Asn Phe Arg Thr Thr Tyr Val Ser 
        275                 280                 285             


Gln Ser Gly Gln Val Ile Ser Ala Pro Arg Ser Ile Gly Leu His Tyr 
    290                 295                 300                 


Leu Ala Thr Trp Phe Phe Ile Asp Leu Ile Ala Ala Leu Pro Phe Asp 
305                 310                 315                 320 


Leu Leu Tyr Ile Phe Asn Ile Thr Val Thr Ser Leu Val His Leu Leu 
                325                 330                 335     


Lys Thr Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Gln Lys Leu Glu 
            340                 345                 350         


Arg Tyr Ser Gln Cys Ser Ala Val Val Leu Thr Leu Leu Met Ser Val 
        355                 360                 365             


Phe Ala Leu Leu Ala His Trp Met Ala Cys Ile Trp Tyr Val Ile Gly 
    370                 375                 380                 


Arg Arg Glu Met Glu Ala Asn Asp Pro Leu Leu Trp Asp Ile Gly Trp 
385                 390                 395                 400 


Leu His Glu Leu Gly Lys Arg Leu Glu Val Pro Tyr Val Asn Gly Ser 
                405                 410                 415     


Val Gly Gly Pro Ser Arg Arg Ser Ala Tyr Ile Ala Ala Leu Tyr Phe 
            420                 425                 430         


Thr Leu Ser Ser Leu Thr Ser Val Gly Phe Gly Asn Val Cys Ala Asn 
        435                 440                 445             


Thr Asp Ala Glu Lys Ile Phe Ser Ile Cys Thr Met Leu Ile Gly Ala 
    450                 455                 460                 


Leu Met His Ala Val Val Phe Gly Asn Val Thr Ala Ile Ile Gln Arg 
465                 470                 475                 480 


Met Tyr Ser Arg Arg Ser Leu Tyr His Ser Arg Met Lys Asp Leu Lys 
                485                 490                 495     


Asp Phe Ile Arg Val His Arg Leu Pro Arg Pro Leu Lys Gln Arg Met 
            500                 505                 510         


Leu Glu Tyr Phe Gln Thr Thr Trp Ala Val Asn Ser Gly Ile Asp Ala 
        515                 520                 525             


Asn Glu Leu Leu Arg Asp Phe Pro Asp Glu Leu Arg Ala Asp Ile Ala 
    530                 535                 540                 


Met His Leu Asn Arg Glu Ile Leu Gln Leu Pro Leu Phe Gly Ala Ala 
545                 550                 555                 560 


Ser Arg Gly Cys Leu Arg Ala Leu Ser Leu His Ile Lys Thr Ser Phe 
                565                 570                 575     


Cys Ala Pro Gly Glu Tyr Leu Leu Arg Arg Gly Asp Ala Leu Gln Ala 
            580                 585                 590         


His Tyr Tyr Val Cys Ser Gly Ser Leu Glu Val Leu Arg Asp Asn Met 
        595                 600                 605             


Val Leu Ala Ile Leu Gly Lys Gly Asp Leu Ile Gly Ala Asp Ile Pro 
    610                 615                 620                 


Glu Pro Gly Gln Glu Pro Gly Leu Gly Ala Asp Pro Asn Phe Val Leu 
625                 630                 635                 640 


Lys Thr Ser Ala Asp Val Lys Ala Leu Thr Tyr Cys Gly Leu Gln Gln 
                645                 650                 655     


Leu Ser Ser Arg Gly Leu Ala Glu Val Leu Arg Leu Tyr Pro Glu Tyr 
            660                 665                 670         


Gly Ala Ala Phe Arg Ala Gly Leu Pro Arg Asp Leu Thr Phe Asn Leu 
        675                 680                 685             


Arg Gln Gly Ser Asp Thr Ser Gly Leu Ser Arg Phe Ser Arg Ser Pro 
    690                 695                 700                 


Arg Leu Ser Gln Pro Arg Ser Glu Ser Leu Gly Ser Ser Ser Asp Lys 
705                 710                 715                 720 


Thr Leu Pro Ser Ile Thr Glu Ala Glu Ser Gly Ala Glu Pro Gly Gly 
                725                 730                 735     


Gly Pro Arg Pro Arg Arg Pro Leu Leu Leu Pro Asn Leu Ser Pro Ala 
            740                 745                 750         


Arg Pro Arg Gly Ser Leu Val Ser Leu Leu Gly Glu Glu Leu Pro Pro 
        755                 760                 765             


Phe Ser Ala Leu Val Ser Ser Pro Ser Leu Ser Pro Ser Leu Ser Pro 
    770                 775                 780                 


Ala Leu Ala Gly Gln Gly His Ser Ala Ser Pro His Gly Pro Pro Arg 
785                 790                 795                 800 


Cys Ser Ala Ala Trp Lys Pro Pro Gln Leu Leu Ile Pro Pro Leu Gly 
                805                 810                 815     


Thr Phe Gly Pro Pro Asp Leu Ser Pro Arg Ile Val Asp Gly Ile Glu 
            820                 825                 830         


Asp Ser Gly Ser Thr Ala Glu Ala Pro Ser Phe Arg Phe Ser Arg Arg 
        835                 840                 845             


Pro Glu Leu Pro Arg Pro Arg Ser Gln Ala Pro Pro Thr Gly Thr Arg 
    850                 855                 860                 


Pro Ser Pro Glu Leu Ala Ser Glu Ala Glu Glu Val Lys Glu Lys Val 
865                 870                 875                 880 


Cys Arg Leu Asn Gln Glu Ile Ser Arg Leu Asn Gln Glu Val Ser Gln 
                885                 890                 895     


Leu Ser Arg Glu Leu Arg His Ile Met Gly Leu Leu Gln Ala Arg Leu 
            900                 905                 910         


Gly Pro Pro Gly His Pro Ala Gly Ser Ala Trp Thr Pro Asp Pro Pro 
        915                 920                 925             


Cys Pro Gln Leu Arg Pro Pro Cys Leu Ser Pro Cys Ala Ser Arg Pro 
    930                 935                 940                 


Pro Pro Ser Leu Gln Asp Thr Thr Leu Ala Glu Val His Cys Pro Ala 
945                 950                 955                 960 


Ser Val Gly Thr Met Glu Thr Gly Thr Ala Leu Leu Asp Leu Arg Pro 
                965                 970                 975     


Ser Ile Leu Pro Pro Tyr Pro Ser Glu Pro Asp Pro Leu Gly Pro Ser 
            980                 985                 990         


Pro Val Pro Glu Ala Ser Pro Pro  Thr Pro Ser Leu Leu  Arg His Ser 
        995                 1000                 1005             


Phe Gln  Ser Arg Ser Asp Thr  Phe His 
    1010                 1015         


<210>  3468
<211>  577
<212>  DNA
<213>  Homosapiens

<400>  3468
cacaattgac agcctcaagg ttcctggctt tttgaaccac cacagacatc tcctttcccg     60

gctaccccac cctgagcgcc agacaccatg aaccttcctt ccacaaaggt ctcctgggcc    120

gccgtgacgc tactgctgct gctgctgctg ctgccgcccg cgctgttgtc gtccggggcg    180

gctgcacagc ccctgcccga ctgctgtcgt caaaagactt gctcttgccg cctctacgag    240

ctgctgcacg gcgcgggcaa tcacgcggcc ggcatcctca cgctgggcaa gcggaggtcc    300

gggcccccgg gcctccaggg tcggctgcag cgcctcctgc aggccagcgg caaccacgcc    360

gcgggcatcc tgaccatggg ccgccgcgca ggcgcagagc cagcgccgcg cccctgcctc    420

gggcgccgct gttccgcccc ggccgccgcc tccgtcgcgc ccggaggaca gtccgggatc    480

tgagtcgttc ttcgggccct gtcctggccc aggcctctgc cctctgccca cccagcgtca    540

gcccccagaa aaaaggcaat aaagacgagt ctccatt                             577


<210>  3469
<211>  131
<212>  PRT
<213>  Homosapiens

<400>  3469

Met Asn Leu Pro Ser Thr Lys Val Ser Trp Ala Ala Val Thr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Pro Ala Leu Leu Ser Ser Gly Ala Ala 
            20                  25                  30          


Ala Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg 
        35                  40                  45              


Leu Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu 
    50                  55                  60                  


Thr Leu Gly Lys Arg Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu 
65                  70                  75                  80  


Gln Arg Leu Leu Gln Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr 
                85                  90                  95      


Met Gly Arg Arg Ala Gly Ala Glu Pro Ala Pro Arg Pro Cys Leu Gly 
            100                 105                 110         


Arg Arg Cys Ser Ala Pro Ala Ala Ala Ser Val Ala Pro Gly Gly Gln 
        115                 120                 125             


Ser Gly Ile 
    130     


<210>  3470
<211>  2649
<212>  DNA
<213>  Homosapiens

<400>  3470
cttttctttt ttttttgaca gggtctcact ctgttgccca agctggggtg cagtggcacg     60

atcttggctc actgtagcct tgacatcctg ggctcaaggg atcctcccat ctcagcctcc    120

caagtagctg cgactatggg tgtgacacca cgctgggcta gtttttcaat tttttgtaga    180

gatggagtct ccctatgttg ctcaggccgg ttgcgaactc ctgggctcaa gtgattctcc    240

tgcctcagcc tcccaaagtg ctgggattac agatgatagc cacctcaccc ggcccacccc    300

taccttctga aagaggcatt cttattctta ttcccatttt gcagatcagg aaacagagct    360

cagtgcagcc cactaaattg ctcagggccc tacagctaac aagcggcaga ggcaggatct    420

gcactcagga gctgcttgga gatgctgctg tggccactgc tgctgctgct gctgctgctg    480

ccaacattgg ccctgctcag gcagcagcgg tcccaggatg ccaggctgtc ctggcttgct    540

ggcctccagc accgagtggc atggggggcc ctggtctggg cagccacctg gcagcgccgg    600

aggctggagc agagcacgct ccatgtgcac cagagccagc agcaggccct gaggtggtgt    660

ctacagggag cccagcgccc ccactgttcc ctcagaagga gcacagacat aagcaccttc    720

cggaatcatc tccctctgac caaggccagc cagacccagc aggaagacag tggagagcag    780

ccactgcccc cgacctcaaa ccaggacctt ggggaggcct ctctgcaggc caccttgctg    840

ggtctggcag ccctaaacaa ggcctaccca gaagtgctgg ctcagggacg cactgcccgt    900

gtgacgctca catccccttg gccccgaccc ctgccttggc ctgggaatac cctgggccag    960

gtgggcaccc ctggaaccaa ggaccctagg gccctgctgc tggacgcact gaggtcccca   1020

gggctgaggg cactggaggc tgggacggct gtcgaacttc tggatgtttt cttgggcctg   1080

gagactgatg gtgaagagct agctggggcg atagctgccg ggaaccctgg agcgcctctc   1140

cgtgaacggg cagctgagct ccgggaggcc ctagagcagg ggccacgggg actggccctt   1200

cggctctggc caaagctgca ggtggtggtg actctggatg caggaggcca ggccgaggct   1260

gtggctgccc tcggggcctt gtggtgccaa ggactagcct tcttctctcc tgcttatgct   1320

gcctcgggag gggtgctggg cctaaaccta cagccagagc agccccatgg gctctacctt   1380

ctgccccctg gggccccctt tatcgagctg ctcccagtca aggaaggcac ccaggaggaa   1440

gctgcctcca ccctcctttt ggccgaggcc cagcagggca aggagtatga gctggtgctg   1500

acggaccgcg ccagcctcac caggtgccgc ctgggtgatg tggtgcgagt ggttggtgcc   1560

tacaatcagt gtccagtcgt caggttcatc tgcaggctgg accagaccct gagtgtgcga   1620

ggggaagata ttggtgaaga cctgttctct gaggccctgg gccgggcagt ggggcagtgg   1680

gcgggggcca agctgctgga ccatggctgt gtggagagca gcattctgga ttcctctgcg   1740

ggctctgctc cccactacga ggtgtttgtg gcgctgaggg ggctgaggaa tctgtcagag   1800

gaaaatcgag acaagctgga ccactgcctt caggaagcct ctccccgcta caagtccctg   1860

cggttctggg gcagcgtggg ccctgccaga gtccacctgg tggggcaggg agccttccga   1920

gcactccggg cagccctcgc tgcctgcccc tcctccccct tcccccctgc gatgccccgg   1980

gtccttcggc acaggcacct ggcccagtgt ctgcaggaga gggtggtgtc ctgagtcaag   2040

tcctgcccca ccgcccagct ccccccagag gccacctcgc ccctccctct gggacctctc   2100

cggatgggga gtccttggcc agggtctctg actctgtgtc acctgacatt tgcccatgag   2160

agccgctggg ccttagagag gccttggccc agctgaccgg ttctgaagta tgggcctccg   2220

gggttagcag atgccagcag tgcctgcccg tgtccccatg tcccggcatg aaggacactg   2280

ctagagagtt accatgcaca ccgatggttt cctgtatcac agcccaaaga ggttctctgg   2340

tggccacagc tgtgtgctca gtcagtgcac tgggcaagct agaagtgttg gggggttaat   2400

gtccccagga gcagcaaccc tgagtcaata aggagcagga cctcagcttc attgtccttg   2460

agcaggacaa ttctgaagtg tattctacat aaactctcag aggatgccca gcaggatgga   2520

gtcccagttg cccgcagcag taacccactc attcatgtac ttcctgcggg ggctctccct   2580

tccctctctt ccccactccc ccgccttggg cttcctggga tggctcccaa ataaacctct   2640

tgcacccag                                                           2649


<210>  3471
<211>  530
<212>  PRT
<213>  Homosapiens

<400>  3471

Met Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Thr Leu 
1               5                   10                  15      


Ala Leu Leu Arg Gln Gln Arg Ser Gln Asp Ala Arg Leu Ser Trp Leu 
            20                  25                  30          


Ala Gly Leu Gln His Arg Val Ala Trp Gly Ala Leu Val Trp Ala Ala 
        35                  40                  45              


Thr Trp Gln Arg Arg Arg Leu Glu Gln Ser Thr Leu His Val His Gln 
    50                  55                  60                  


Ser Gln Gln Gln Ala Leu Arg Trp Cys Leu Gln Gly Ala Gln Arg Pro 
65                  70                  75                  80  


His Cys Ser Leu Arg Arg Ser Thr Asp Ile Ser Thr Phe Arg Asn His 
                85                  90                  95      


Leu Pro Leu Thr Lys Ala Ser Gln Thr Gln Gln Glu Asp Ser Gly Glu 
            100                 105                 110         


Gln Pro Leu Pro Pro Thr Ser Asn Gln Asp Leu Gly Glu Ala Ser Leu 
        115                 120                 125             


Gln Ala Thr Leu Leu Gly Leu Ala Ala Leu Asn Lys Ala Tyr Pro Glu 
    130                 135                 140                 


Val Leu Ala Gln Gly Arg Thr Ala Arg Val Thr Leu Thr Ser Pro Trp 
145                 150                 155                 160 


Pro Arg Pro Leu Pro Trp Pro Gly Asn Thr Leu Gly Gln Val Gly Thr 
                165                 170                 175     


Pro Gly Thr Lys Asp Pro Arg Ala Leu Leu Leu Asp Ala Leu Arg Ser 
            180                 185                 190         


Pro Gly Leu Arg Ala Leu Glu Ala Gly Thr Ala Val Glu Leu Leu Asp 
        195                 200                 205             


Val Phe Leu Gly Leu Glu Thr Asp Gly Glu Glu Leu Ala Gly Ala Ile 
    210                 215                 220                 


Ala Ala Gly Asn Pro Gly Ala Pro Leu Arg Glu Arg Ala Ala Glu Leu 
225                 230                 235                 240 


Arg Glu Ala Leu Glu Gln Gly Pro Arg Gly Leu Ala Leu Arg Leu Trp 
                245                 250                 255     


Pro Lys Leu Gln Val Val Val Thr Leu Asp Ala Gly Gly Gln Ala Glu 
            260                 265                 270         


Ala Val Ala Ala Leu Gly Ala Leu Trp Cys Gln Gly Leu Ala Phe Phe 
        275                 280                 285             


Ser Pro Ala Tyr Ala Ala Ser Gly Gly Val Leu Gly Leu Asn Leu Gln 
    290                 295                 300                 


Pro Glu Gln Pro His Gly Leu Tyr Leu Leu Pro Pro Gly Ala Pro Phe 
305                 310                 315                 320 


Ile Glu Leu Leu Pro Val Lys Glu Gly Thr Gln Glu Glu Ala Ala Ser 
                325                 330                 335     


Thr Leu Leu Leu Ala Glu Ala Gln Gln Gly Lys Glu Tyr Glu Leu Val 
            340                 345                 350         


Leu Thr Asp Arg Ala Ser Leu Thr Arg Cys Arg Leu Gly Asp Val Val 
        355                 360                 365             


Arg Val Val Gly Ala Tyr Asn Gln Cys Pro Val Val Arg Phe Ile Cys 
    370                 375                 380                 


Arg Leu Asp Gln Thr Leu Ser Val Arg Gly Glu Asp Ile Gly Glu Asp 
385                 390                 395                 400 


Leu Phe Ser Glu Ala Leu Gly Arg Ala Val Gly Gln Trp Ala Gly Ala 
                405                 410                 415     


Lys Leu Leu Asp His Gly Cys Val Glu Ser Ser Ile Leu Asp Ser Ser 
            420                 425                 430         


Ala Gly Ser Ala Pro His Tyr Glu Val Phe Val Ala Leu Arg Gly Leu 
        435                 440                 445             


Arg Asn Leu Ser Glu Glu Asn Arg Asp Lys Leu Asp His Cys Leu Gln 
    450                 455                 460                 


Glu Ala Ser Pro Arg Tyr Lys Ser Leu Arg Phe Trp Gly Ser Val Gly 
465                 470                 475                 480 


Pro Ala Arg Val His Leu Val Gly Gln Gly Ala Phe Arg Ala Leu Arg 
                485                 490                 495     


Ala Ala Leu Ala Ala Cys Pro Ser Ser Pro Phe Pro Pro Ala Met Pro 
            500                 505                 510         


Arg Val Leu Arg His Arg His Leu Ala Gln Cys Leu Gln Glu Arg Val 
        515                 520                 525             


Val Ser 
    530 


<210>  3472
<211>  5171
<212>  DNA
<213>  Homosapiens

<400>  3472
ggcgggagga gagtcggcgg ccggagccgt caccccgggc ggggacccag cgcaggcaac     60

tccgcgcggc ggcccggccg agggagggag cgagcgggcg ggcgggcaag ccagacagct    120

gggccggagc agccgcgggc gcccgagggg ccgagcgaga ttgtaaacca tggctgtgtg    180

gatacaagct cagcagctcc aaggagaagc ccttcatcag atgcaagcgt tatatggcca    240

gcattttccc attgaggtgc ggcattattt atcccagtgg attgaaagcc aagcatggga    300

ctcagtagat cttgataatc cacaggagaa cattaaggcc acccagctcc tggagggcct    360

ggtgcaggag ctgcagaaga aggcagagca ccaggtgggg gaagatgggt ttttactgaa    420

gatcaagctg gggcactatg ccacacagct ccagaacacg tatgaccgct gccccatgga    480

gctggtccgc tgcatccgcc atatattgta caatgaacag aggttggtcc gagaagccaa    540

caatggtagc tctccagctg gaagccttgc tgatgccatg tcccagaaac acctccagat    600

caaccagacg tttgaggagc tgcgactggt cacgcaggac acagagaatg agttaaaaaa    660

gctgcagcag actcaggagt acttcatcat ccagtaccag gagagcctga ggatccaagc    720

tcagtttggc ccgctggccc agctgagccc ccaggagcgt ctgagccggg agacggccct    780

ccagcagaag caggtgtctc tggaggcctg gttgcagcgt gaggcacaga cactgcagca    840

gtaccgcgtg gagctggccg agaagcacca gaagaccctg cagctgctgc ggaagcagca    900

gaccatcatc ctggatgacg agctgatcca gtggaagcgg cggcagcagc tggccgggaa    960

cggcgggccc cccgagggca gcctggacgt gctacagtcc tggtgtgaga agttggccga   1020

gatcatctgg cagaaccggc agcagatccg cagggctgag cacctctgcc agcagctgcc   1080

catccccggc ccagtggagg agatgctggc cgaggtcaac gccaccatca cggacattat   1140

ctcagccctg gtgaccagca cgttcatcat tgagaagcag cctcctcagg tcctgaagac   1200

ccagaccaag tttgcagcca ctgtgcgcct gctggtgggc gggaagctga acgtgcacat   1260

gaaccccccc caggtgaagg ccaccatcat cagtgagcag caggccaagt ctctgctcaa   1320

gaacgagaac acccgcaatg attacagtgg cgagatcttg aacaactgct gcgtcatgga   1380

gtaccaccaa gccacaggca cccttagtgc ccacttcagg aatatgtccc tgaaacgaat   1440

taagaggtca gaccgtcgtg gggcagagtc ggtgacagaa gaaaaattta caatcctgtt   1500

tgaatcccag ttcagtgttg gtggaaatga gctggttttt caagtcaaga ccctgtccct   1560

gccagtggtg gtgatcgttc atggcagcca ggacaacaat gcgacggcca ctgttctctg   1620

ggacaatgct tttgcagagc ctggcagggt gccatttgcc gtgcctgaca aagtgctgtg   1680

gccacagctg tgtgaggcgc tcaacatgaa attcaaggcc gaagtgcaga gcaaccgggg   1740

cctgaccaag gagaacctcg tgttcctggc gcagaaactg ttcaacaaca gcagcagcca   1800

cctggaggac tacagtggcc tgtctgtgtc ctggtcccag ttcaacaggg agaatttacc   1860

aggacggaat tacactttct ggcaatggtt tgacggtgtg atggaagtgt taaaaaaaca   1920

tctcaagcct cattggaatg atggggccat tttggggttt gtaaacaagc aacaggccca   1980

tgacctactc attaacaagc cagatgggac cttcctcctg agattcagtg actcagaaat   2040

tggcggcatc accattgctt ggaagtttga ttctcaggaa agaatgtttt ggaatctgat   2100

gccttttacc accagagact tctccattcg gtccctagcc gaccgcttgg gagacttgaa   2160

ttaccttatc tacgtgtttc ctgatcggcc aaaagatgaa gtatactcca aatactacac   2220

accagttccc tgcgagtctg ctactgctaa agctgttgat ggatacgtga agccacagat   2280

caagcaagtg gtccctgagt ttgtgaacgc atctgcagat gccgggggcg gcagcgccac   2340

gtacatggac caggccccct ccccagctgt gtgtccccag gctcactata acatgtaccc   2400

acagaaccct gactcagtcc ttgacaccga tggggacttc gatctggagg acacaatgga   2460

cgtagcgcgg cgtgtggagg agctcctggg ccggccaatg gacagtcagt ggatcccgca   2520

cgcacaatcg tgaccccgcg acctctccat cttcagcttc ttcatcttca ccagaggaat   2580

cactcttgtg gatgttttaa ttccatgaat cgcttctctt ttgaaacaat actcataatg   2640

tgaagtgtta atactagttg tgaccttagt gtttctgtgc atggtggcac cagcgaaggg   2700

agtgcgagta tgtgtttgtg tgtgtgtgtg tgtgtgtgtg tgtgtgcgtg tttgcacgtt   2760

atggtgtttc tccctctcac tgtctgagag tttagttgta gcagaggggc cacagacaga   2820

agctgtggtg gtttttactt tgtgcaaaaa ggcagtgagt ttcgtgaagc ctggaagttg   2880

gccatgtgtc ttaagagtgg ctggactttg acatgtggct gtttgaataa gagaaggaca   2940

aagggaggag aaagcacatg tgctccagtg agtcttcgtc actctgtctg ccaagcaatt   3000

gatatataac cgtgattgtc tctgcttttc ttctgaaatg tagataactg ctttttgaca   3060

aagagagcct tccctctccc ccacccctgt gttcttgggt aggaatggga aaaggggcaa   3120

cctacaaaga ttgttggggc aagggaagtc acaagctttc ggatgggcgg tggcttttca   3180

caaaacattt agctcatctt attctctctt tgtcctctct cccctcctgc ccgcccgcac   3240

cctggaattg ccactcagtt cctctgggtg tgcacatatg tttggagaaa tagaggagag   3300

aaaagagggc cacgtaactg agagcttaca gtgccaatgc cgtttgtgtt ctggccagag   3360

tggagtgcgc agccctgact cccaggcgct gagattgttg cctggttacc caggaagctg   3420

ctgttccggc tgcccagcct ttctctgagc cagcggatgc acagtccgtg gccttcttca   3480

ggcttattga tgatgctttt tgcaaatgtt gaatcatggt tctgtttcta agttggatct   3540

tttttgtttt ctccttgcca ccctaatttg acatcaaaat tctctcttgt gcattgggcc   3600

ctgggtcatt caaacccagg tcacctcatt ccccttctct gttcacacct aatgtcttga   3660

agagtaggta gcagcagtgt gggctgaacc taggccagct tgcttagcgg gtcaccctgc   3720

tgtgaagtcc tggcaggtgt tggtaatgtg tggaaatgca gtcagcaagt ttgctgggga   3780

gtttgataaa agtataaaac aaaacaaaaa aagcctcggt ataattttgt tccacgactt   3840

cttctgtagc tttacaccag aaggaaggaa tgggctacag caggtagtgg aggaagaggg   3900

gggtgagcag gtgtattaaa atagcttacg ggtaaggcct aaaaggtcac ccctcggccc   3960

cctctccaaa agaagggcat gggcaccccc aggagaggat ggccccaaaa accttatttt   4020

tatacatgag agtaaataaa catatttttt ttacaaaaat aacttctgaa tttatcagtg   4080

ttttgccgtt aaaaatattc ctctatagta aattatttat tggaagatga cttttttaaa   4140

gctgccgttt gccttggctt ggtttcatac actgatttat ttttctatgc caggcagtag   4200

agtctctctg cctctgagga gcaggctacc cgcatcccac tcagcccctc cctacccctc   4260

aagatttgat gaaaattcca accatgagga tgggtgcatc ggggaagggt gagaaggaga   4320

gcctgcctgc tcagggatcc aggctcgtag agtcactccc tgcccgtctc ccagagatgc   4380

ttcaccagca cctgcctctg agacctcgct ctctgttcca gcaaccctgg ttggggggtc   4440

agacttgata cactttcagg ttgggagtgg acccacccca gggcctgctg aggacagagc   4500

agccaggccg tcctggctca ctttgcagtt ggcactgggt tggggaggaa gagagctgat   4560

gagtgtggct tccctgagct ggggtttccc tgcttgtcca gttgtgagct gtcctcggtg   4620

ttaccgaggc tgtgcctaga gagtggagat ttttgatgaa aggtgtgctc gctctctgcg   4680

ttctatcttc tctctcctcc ttgttcctgc aaaccacaag ataaaggtag tggtgtgtct   4740

cgaccccatc agcctctcac ccactcccag acacacacaa gtcctcaaaa gtttcagctc   4800

cgtgtgtgag atgtgcaggt tttttctagg gggtaggggg agactaaaat cgaatataac   4860

ttaaaatgaa agtatacttt ttataatttt tctttttaaa acttggtgaa attatttcag   4920

atacatattt tagtgtcaag gcagattagt tatttagcca ccaaaaaaaa gtattgtgta   4980

caatttgggg cctcaaattt gactctgcct caaaaaaaag aaatatatcc tatgcagagt   5040

tacagtcaca aagttgtgta ttttatgtta caataaagcc ttcctctgaa gggaaaaaaa   5100

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   5160

aaaaaaaaaa a                                                        5171


<210>  3473
<211>  787
<212>  PRT
<213>  Homosapiens

<400>  3473

Met Ala Val Trp Ile Gln Ala Gln Gln Leu Gln Gly Glu Ala Leu His 
1               5                   10                  15      


Gln Met Gln Ala Leu Tyr Gly Gln His Phe Pro Ile Glu Val Arg His 
            20                  25                  30          


Tyr Leu Ser Gln Trp Ile Glu Ser Gln Ala Trp Asp Ser Val Asp Leu 
        35                  40                  45              


Asp Asn Pro Gln Glu Asn Ile Lys Ala Thr Gln Leu Leu Glu Gly Leu 
    50                  55                  60                  


Val Gln Glu Leu Gln Lys Lys Ala Glu His Gln Val Gly Glu Asp Gly 
65                  70                  75                  80  


Phe Leu Leu Lys Ile Lys Leu Gly His Tyr Ala Thr Gln Leu Gln Asn 
                85                  90                  95      


Thr Tyr Asp Arg Cys Pro Met Glu Leu Val Arg Cys Ile Arg His Ile 
            100                 105                 110         


Leu Tyr Asn Glu Gln Arg Leu Val Arg Glu Ala Asn Asn Gly Ser Ser 
        115                 120                 125             


Pro Ala Gly Ser Leu Ala Asp Ala Met Ser Gln Lys His Leu Gln Ile 
    130                 135                 140                 


Asn Gln Thr Phe Glu Glu Leu Arg Leu Val Thr Gln Asp Thr Glu Asn 
145                 150                 155                 160 


Glu Leu Lys Lys Leu Gln Gln Thr Gln Glu Tyr Phe Ile Ile Gln Tyr 
                165                 170                 175     


Gln Glu Ser Leu Arg Ile Gln Ala Gln Phe Gly Pro Leu Ala Gln Leu 
            180                 185                 190         


Ser Pro Gln Glu Arg Leu Ser Arg Glu Thr Ala Leu Gln Gln Lys Gln 
        195                 200                 205             


Val Ser Leu Glu Ala Trp Leu Gln Arg Glu Ala Gln Thr Leu Gln Gln 
    210                 215                 220                 


Tyr Arg Val Glu Leu Ala Glu Lys His Gln Lys Thr Leu Gln Leu Leu 
225                 230                 235                 240 


Arg Lys Gln Gln Thr Ile Ile Leu Asp Asp Glu Leu Ile Gln Trp Lys 
                245                 250                 255     


Arg Arg Gln Gln Leu Ala Gly Asn Gly Gly Pro Pro Glu Gly Ser Leu 
            260                 265                 270         


Asp Val Leu Gln Ser Trp Cys Glu Lys Leu Ala Glu Ile Ile Trp Gln 
        275                 280                 285             


Asn Arg Gln Gln Ile Arg Arg Ala Glu His Leu Cys Gln Gln Leu Pro 
    290                 295                 300                 


Ile Pro Gly Pro Val Glu Glu Met Leu Ala Glu Val Asn Ala Thr Ile 
305                 310                 315                 320 


Thr Asp Ile Ile Ser Ala Leu Val Thr Ser Thr Phe Ile Ile Glu Lys 
                325                 330                 335     


Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe Ala Ala Thr Val 
            340                 345                 350         


Arg Leu Leu Val Gly Gly Lys Leu Asn Val His Met Asn Pro Pro Gln 
        355                 360                 365             


Val Lys Ala Thr Ile Ile Ser Glu Gln Gln Ala Lys Ser Leu Leu Lys 
    370                 375                 380                 


Asn Glu Asn Thr Arg Asn Asp Tyr Ser Gly Glu Ile Leu Asn Asn Cys 
385                 390                 395                 400 


Cys Val Met Glu Tyr His Gln Ala Thr Gly Thr Leu Ser Ala His Phe 
                405                 410                 415     


Arg Asn Met Ser Leu Lys Arg Ile Lys Arg Ser Asp Arg Arg Gly Ala 
            420                 425                 430         


Glu Ser Val Thr Glu Glu Lys Phe Thr Ile Leu Phe Glu Ser Gln Phe 
        435                 440                 445             


Ser Val Gly Gly Asn Glu Leu Val Phe Gln Val Lys Thr Leu Ser Leu 
    450                 455                 460                 


Pro Val Val Val Ile Val His Gly Ser Gln Asp Asn Asn Ala Thr Ala 
465                 470                 475                 480 


Thr Val Leu Trp Asp Asn Ala Phe Ala Glu Pro Gly Arg Val Pro Phe 
                485                 490                 495     


Ala Val Pro Asp Lys Val Leu Trp Pro Gln Leu Cys Glu Ala Leu Asn 
            500                 505                 510         


Met Lys Phe Lys Ala Glu Val Gln Ser Asn Arg Gly Leu Thr Lys Glu 
        515                 520                 525             


Asn Leu Val Phe Leu Ala Gln Lys Leu Phe Asn Asn Ser Ser Ser His 
    530                 535                 540                 


Leu Glu Asp Tyr Ser Gly Leu Ser Val Ser Trp Ser Gln Phe Asn Arg 
545                 550                 555                 560 


Glu Asn Leu Pro Gly Arg Asn Tyr Thr Phe Trp Gln Trp Phe Asp Gly 
                565                 570                 575     


Val Met Glu Val Leu Lys Lys His Leu Lys Pro His Trp Asn Asp Gly 
            580                 585                 590         


Ala Ile Leu Gly Phe Val Asn Lys Gln Gln Ala His Asp Leu Leu Ile 
        595                 600                 605             


Asn Lys Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile 
    610                 615                 620                 


Gly Gly Ile Thr Ile Ala Trp Lys Phe Asp Ser Gln Glu Arg Met Phe 
625                 630                 635                 640 


Trp Asn Leu Met Pro Phe Thr Thr Arg Asp Phe Ser Ile Arg Ser Leu 
                645                 650                 655     


Ala Asp Arg Leu Gly Asp Leu Asn Tyr Leu Ile Tyr Val Phe Pro Asp 
            660                 665                 670         


Arg Pro Lys Asp Glu Val Tyr Ser Lys Tyr Tyr Thr Pro Val Pro Cys 
        675                 680                 685             


Glu Ser Ala Thr Ala Lys Ala Val Asp Gly Tyr Val Lys Pro Gln Ile 
    690                 695                 700                 


Lys Gln Val Val Pro Glu Phe Val Asn Ala Ser Ala Asp Ala Gly Gly 
705                 710                 715                 720 


Gly Ser Ala Thr Tyr Met Asp Gln Ala Pro Ser Pro Ala Val Cys Pro 
                725                 730                 735     


Gln Ala His Tyr Asn Met Tyr Pro Gln Asn Pro Asp Ser Val Leu Asp 
            740                 745                 750         


Thr Asp Gly Asp Phe Asp Leu Glu Asp Thr Met Asp Val Ala Arg Arg 
        755                 760                 765             


Val Glu Glu Leu Leu Gly Arg Pro Met Asp Ser Gln Trp Ile Pro His 
    770                 775                 780                 


Ala Gln Ser 
785         


<210>  3474
<211>  4298
<212>  DNA
<213>  Homosapiens

<400>  3474
cagacaggat attcactgct gtggcaaggc ctgtagagag tttcgaagtt aggaggactc     60

aagacggtcc ctccctggac ttttctgaag gggctcaaaa gatgacacgc gccagagctg    120

gaaggcgtcg ccaattggtc caacttttcc ctcctccctt tttgcggatg agaaaaactg    180

aggcccaggt ttgggatttc cagagcccgg gatttcccgg caacgccgac aaccacattc    240

ccccggctat tctgacccgc cccggttccg ggacgctccc tgggagccgc cgccgagggc    300

ctgctgggac tcccggggac cccgccgtcg gggcagcccc cacgcccggc gccgcccgcc    360

ggaacggcgc cgctgttgcg cacttgcagg ggagccggcg actgagggcg aggcagggag    420

ggagcaagcg gggctgggag ggctgctggc gcgggctcgc cggctgtgta tggtctatcg    480

caggcagctg acctttgagg aggaaatcgc tgctctccgc tccttcctgt agtaacagcc    540

gccgctgccg ccgccgccag gaaccccggc cgggagcgag agccgcgggg cgcagagccg    600

gcccggctgc cggacggtgc ggccccacca ggtgaacggc catggcgggc tggatccagg    660

cccagcagct gcagggagac gcgctgcgcc agatgcaggt gctgtacggc cagcacttcc    720

ccatcgaggt ccggcactac ttggcccagt ggattgagag ccagccatgg gatgccattg    780

acttggacaa tccccaggac agagcccaag ccacccagct cctggagggc ctggtgcagg    840

agctgcagaa gaaggcggag caccaggtgg gggaagatgg gtttttactg aagatcaagc    900

tggggcacta cgccacgcag ctccagaaaa catatgaccg ctgccccctg gagctggtcc    960

gctgcatccg gcacattctg tacaatgaac agaggctggt ccgagaagcc aacaattgca   1020

gctctccggc tgggatcctg gttgacgcca tgtcccagaa gcaccttcag atcaaccaga   1080

catttgagga gctgcgactg gtcacgcagg acacagagaa tgagctgaag aaactgcagc   1140

agactcagga gtacttcatc atccagtacc aggagagcct gaggatccaa gctcagtttg   1200

cccagctggc ccagctgagc ccccaggagc gtctgagccg ggagacggcc ctccagcaga   1260

agcaggtgtc tctggaggcc tggttgcagc gtgaggcaca gacactgcag cagtaccgcg   1320

tggagctggc cgagaagcac cagaagaccc tgcagctgct gcggaagcag cagaccatca   1380

tcctggatga cgagctgatc cagtggaagc ggcggcagca gctggccggg aacggcgggc   1440

cccccgaggg cagcctggac gtgctacagt cctggtgtga gaagttggcc gagatcatct   1500

ggcagaaccg gcagcagatc cgcagggctg agcacctctg ccagcagctg cccatccccg   1560

gcccagtgga ggagatgctg gccgaggtca acgccaccat cacggacatt atctcagccc   1620

tggtgaccag cacattcatc attgagaagc agcctcctca ggtcctgaag acccagacca   1680

agtttgcagc caccgtacgc ctgctggtgg gcgggaagct gaacgtgcac atgaatcccc   1740

cccaggtgaa ggccaccatc atcagtgagc agcaggccaa gtctctgctt aaaaatgaga   1800

acacccgcaa cgagtgcagt ggtgagatcc tgaacaactg ctgcgtgatg gagtaccacc   1860

aagccacggg caccctcagt gcccacttca ggaacatgtc actgaagagg atcaagcgtg   1920

ctgaccggcg gggtgcagag tccgtgacag aggagaagtt cacagtcctg tttgagtctc   1980

agttcagtgt tggcagcaat gagcttgtgt tccaggtgaa gactctgtcc ctacctgtgg   2040

ttgtcatcgt ccacggcagc caggaccaca atgccacggc tactgtgctg tgggacaatg   2100

cctttgctga gccgggcagg gtgccatttg ccgtgcctga caaagtgctg tggccgcagc   2160

tgtgtgaggc gctcaacatg aaattcaagg ccgaagtgca gagcaaccgg ggcctgacca   2220

aggagaacct cgtgttcctg gcgcagaaac tgttcaacaa cagcagcagc cacctggagg   2280

actacagtgg cctgtccgtg tcctggtccc agttcaacag ggagaacttg ccgggctgga   2340

actacacctt ctggcagtgg tttgacgggg tgatggaggt gttgaagaag caccacaagc   2400

cccactggaa tgatggggcc atcctaggtt ttgtgaataa gcaacaggcc cacgacctgc   2460

tcatcaacaa gcccgacggg accttcttgt tgcgctttag tgactcagaa atcgggggca   2520

tcaccatcgc ctggaagttt gactccccgg aacgcaacct gtggaacctg aaaccattca   2580

ccacgcggga tttctccatc aggtccctgg ctgaccggct gggggacctg agctatctca   2640

tctatgtgtt tcctgaccgc cccaaggatg aggtcttctc caagtactac actcctgtgc   2700

tggctaaagc tgttgatgga tatgtgaaac cacagatcaa gcaagtggtc cctgagtttg   2760

tgaatgcatc tgcagatgct gggggcagca gcgccacgta catggaccag gccccctccc   2820

cagctgtgtg cccccaggct ccctataaca tgtacccaca gaaccctgac catgtactcg   2880

atcaggatgg agaattcgac ctggatgaga ccatggatgt ggccaggcac gtggaggaac   2940

tcttacgccg accaatggac agtcttgact cccgcctctc gccccctgcc ggtcttttca   3000

cctctgccag aggctccctc tcatgaatgt ttgaatccca cgcttctctt tggaaacaat   3060

atgcaatgtg aagcggtcgt gttgtgagtt tagtaaggtt gtgtacactg acacctttgc   3120

aggcatgcat gtgcttgtgt gtgtgtgtgt gtgtgtgtcc ttgtgcatga gctacgcctg   3180

cctcccctgt gcagtcctgg gatgtggctg cagcagcggt ggcctctttt cagatcatgg   3240

catccaagag tgcgccgagt ctgtctctgt catggtagag accgagcctc tgtcactgca   3300

ggcactcaat gcagccagac ctattcctcc tgggcccctc atctgctcag cagctatttg   3360

aatgagatga ttcagaaggg gaggggagac aggtaacgtc tgtaagctga agtttcactc   3420

cggagtgaga agctttgccc tcctaagaga gagagacaga gagacagaga gagagaaaga   3480

gagagtgtgt gggtctatgt aaatgcatct gtcctcatgt gttgatgtaa ccgattcatc   3540

tctcagaagg gaggctgggg gttcattttc gagtagtatt ttatacttta gtgaacgtgg   3600

actccagact ctctgtgaac cctatgagag cgcgtctggg cccggccatg tccttagcac   3660

aggggggccg ccggtttgag tgagggtttc tgagctgctc tgaattagtc cttgcttggc   3720

tgcttggcct tgggcttcat tcaagtctat gatgctgttg cccacgtttc ccgggatata   3780

tattctctcc cctccgttgg gccccagcct tctttgcttg cctctctgtt tgtaaccttg   3840

tcgacaaaga ggtagaaaag attgggtcta ggatatggtg ggtggacagg ggccccggga   3900

cttggagggt tggtcctctt gcctcctgga aaaaacaaaa acaaaaaact gcagtgaaag   3960

acaagctgca aatcagccat gtgctgcgtg cctgtggaat ctggagtgag gggtaaaagc   4020

tgatctggtt tgactccgct ggaggtgggg cctggagcag gccttgcgct gttgcgtaac   4080

tggctgtgtt ctggtgaggc cttgctccca accccacacg ctcctccctc tgaggctgta   4140

ggactcgcag tcaggggcag ctgaccatgg aagattgaga gcccaaggtt taaacttctc   4200

tgaagggagg tggggatgag aagaggggtt tttttgtact ttgtacaaag accacacatt   4260

tgtgtaaaca gtgttttgga ataaaatatt tttttcat                           4298


<210>  3475
<211>  794
<212>  PRT
<213>  Homosapiens

<400>  3475

Met Ala Gly Trp Ile Gln Ala Gln Gln Leu Gln Gly Asp Ala Leu Arg 
1               5                   10                  15      


Gln Met Gln Val Leu Tyr Gly Gln His Phe Pro Ile Glu Val Arg His 
            20                  25                  30          


Tyr Leu Ala Gln Trp Ile Glu Ser Gln Pro Trp Asp Ala Ile Asp Leu 
        35                  40                  45              


Asp Asn Pro Gln Asp Arg Ala Gln Ala Thr Gln Leu Leu Glu Gly Leu 
    50                  55                  60                  


Val Gln Glu Leu Gln Lys Lys Ala Glu His Gln Val Gly Glu Asp Gly 
65                  70                  75                  80  


Phe Leu Leu Lys Ile Lys Leu Gly His Tyr Ala Thr Gln Leu Gln Lys 
                85                  90                  95      


Thr Tyr Asp Arg Cys Pro Leu Glu Leu Val Arg Cys Ile Arg His Ile 
            100                 105                 110         


Leu Tyr Asn Glu Gln Arg Leu Val Arg Glu Ala Asn Asn Cys Ser Ser 
        115                 120                 125             


Pro Ala Gly Ile Leu Val Asp Ala Met Ser Gln Lys His Leu Gln Ile 
    130                 135                 140                 


Asn Gln Thr Phe Glu Glu Leu Arg Leu Val Thr Gln Asp Thr Glu Asn 
145                 150                 155                 160 


Glu Leu Lys Lys Leu Gln Gln Thr Gln Glu Tyr Phe Ile Ile Gln Tyr 
                165                 170                 175     


Gln Glu Ser Leu Arg Ile Gln Ala Gln Phe Ala Gln Leu Ala Gln Leu 
            180                 185                 190         


Ser Pro Gln Glu Arg Leu Ser Arg Glu Thr Ala Leu Gln Gln Lys Gln 
        195                 200                 205             


Val Ser Leu Glu Ala Trp Leu Gln Arg Glu Ala Gln Thr Leu Gln Gln 
    210                 215                 220                 


Tyr Arg Val Glu Leu Ala Glu Lys His Gln Lys Thr Leu Gln Leu Leu 
225                 230                 235                 240 


Arg Lys Gln Gln Thr Ile Ile Leu Asp Asp Glu Leu Ile Gln Trp Lys 
                245                 250                 255     


Arg Arg Gln Gln Leu Ala Gly Asn Gly Gly Pro Pro Glu Gly Ser Leu 
            260                 265                 270         


Asp Val Leu Gln Ser Trp Cys Glu Lys Leu Ala Glu Ile Ile Trp Gln 
        275                 280                 285             


Asn Arg Gln Gln Ile Arg Arg Ala Glu His Leu Cys Gln Gln Leu Pro 
    290                 295                 300                 


Ile Pro Gly Pro Val Glu Glu Met Leu Ala Glu Val Asn Ala Thr Ile 
305                 310                 315                 320 


Thr Asp Ile Ile Ser Ala Leu Val Thr Ser Thr Phe Ile Ile Glu Lys 
                325                 330                 335     


Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe Ala Ala Thr Val 
            340                 345                 350         


Arg Leu Leu Val Gly Gly Lys Leu Asn Val His Met Asn Pro Pro Gln 
        355                 360                 365             


Val Lys Ala Thr Ile Ile Ser Glu Gln Gln Ala Lys Ser Leu Leu Lys 
    370                 375                 380                 


Asn Glu Asn Thr Arg Asn Glu Cys Ser Gly Glu Ile Leu Asn Asn Cys 
385                 390                 395                 400 


Cys Val Met Glu Tyr His Gln Ala Thr Gly Thr Leu Ser Ala His Phe 
                405                 410                 415     


Arg Asn Met Ser Leu Lys Arg Ile Lys Arg Ala Asp Arg Arg Gly Ala 
            420                 425                 430         


Glu Ser Val Thr Glu Glu Lys Phe Thr Val Leu Phe Glu Ser Gln Phe 
        435                 440                 445             


Ser Val Gly Ser Asn Glu Leu Val Phe Gln Val Lys Thr Leu Ser Leu 
    450                 455                 460                 


Pro Val Val Val Ile Val His Gly Ser Gln Asp His Asn Ala Thr Ala 
465                 470                 475                 480 


Thr Val Leu Trp Asp Asn Ala Phe Ala Glu Pro Gly Arg Val Pro Phe 
                485                 490                 495     


Ala Val Pro Asp Lys Val Leu Trp Pro Gln Leu Cys Glu Ala Leu Asn 
            500                 505                 510         


Met Lys Phe Lys Ala Glu Val Gln Ser Asn Arg Gly Leu Thr Lys Glu 
        515                 520                 525             


Asn Leu Val Phe Leu Ala Gln Lys Leu Phe Asn Asn Ser Ser Ser His 
    530                 535                 540                 


Leu Glu Asp Tyr Ser Gly Leu Ser Val Ser Trp Ser Gln Phe Asn Arg 
545                 550                 555                 560 


Glu Asn Leu Pro Gly Trp Asn Tyr Thr Phe Trp Gln Trp Phe Asp Gly 
                565                 570                 575     


Val Met Glu Val Leu Lys Lys His His Lys Pro His Trp Asn Asp Gly 
            580                 585                 590         


Ala Ile Leu Gly Phe Val Asn Lys Gln Gln Ala His Asp Leu Leu Ile 
        595                 600                 605             


Asn Lys Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile 
    610                 615                 620                 


Gly Gly Ile Thr Ile Ala Trp Lys Phe Asp Ser Pro Glu Arg Asn Leu 
625                 630                 635                 640 


Trp Asn Leu Lys Pro Phe Thr Thr Arg Asp Phe Ser Ile Arg Ser Leu 
                645                 650                 655     


Ala Asp Arg Leu Gly Asp Leu Ser Tyr Leu Ile Tyr Val Phe Pro Asp 
            660                 665                 670         


Arg Pro Lys Asp Glu Val Phe Ser Lys Tyr Tyr Thr Pro Val Leu Ala 
        675                 680                 685             


Lys Ala Val Asp Gly Tyr Val Lys Pro Gln Ile Lys Gln Val Val Pro 
    690                 695                 700                 


Glu Phe Val Asn Ala Ser Ala Asp Ala Gly Gly Ser Ser Ala Thr Tyr 
705                 710                 715                 720 


Met Asp Gln Ala Pro Ser Pro Ala Val Cys Pro Gln Ala Pro Tyr Asn 
                725                 730                 735     


Met Tyr Pro Gln Asn Pro Asp His Val Leu Asp Gln Asp Gly Glu Phe 
            740                 745                 750         


Asp Leu Asp Glu Thr Met Asp Val Ala Arg His Val Glu Glu Leu Leu 
        755                 760                 765             


Arg Arg Pro Met Asp Ser Leu Asp Ser Arg Leu Ser Pro Pro Ala Gly 
    770                 775                 780                 


Leu Phe Thr Ser Ala Arg Gly Ser Leu Ser 
785                 790                 


<210>  3476
<211>  4953
<212>  DNA
<213>  Homosapiens

<400>  3476
ggtttccgga gctgcggcgg cgcagactgg gagggggagc cgggggttcc gacgtcgcag     60

ccgagggaac aagccccaac cggatcctgg acaggcaccc cggcttggcg ctgtctctcc    120

ccctcggctc ggagaggccc ttcggcctga gggagcctcg ccgcccgtcc ccggcacacg    180

cgcagccccg gcctctcggc ctctgccgga gaaacaggat ggcccaatgg aatcagctac    240

agcagcttga cacacggtac ctggagcagc tccatcagct ctacagtgac agcttcccaa    300

tggagctgcg gcagtttctg gccccttgga ttgagagtca agattgggca tatgcggcca    360

gcaaagaatc acatgccact ttggtgtttc ataatctcct gggagagatt gaccagcagt    420

atagccgctt cctgcaagag tcgaatgttc tctatcagca caatctacga agaatcaagc    480

agtttcttca gagcaggtat cttgagaagc caatggagat tgcccggatt gtggcccggt    540

gcctgtggga agaatcacgc cttctacaga ctgcagccac tgcggcccag caagggggcc    600

aggccaacca ccccacagca gccgtggtga cggagaagca gcagatgctg gagcagcacc    660

ttcaggatgt ccggaagaga gtgcaggatc tagaacagaa aatgaaagtg gtagagaatc    720

tccaggatga ctttgatttc aactataaaa ccctcaagag tcaaggagac atgcaagatc    780

tgaatggaaa caaccagtca gtgaccaggc agaagatgca gcagctggaa cagatgctca    840

ctgcgctgga ccagatgcgg agaagcatcg tgagtgagct ggcggggctt ttgtcagcga    900

tggagtacgt gcagaaaact ctcacggacg aggagctggc tgactggaag aggcggcaac    960

agattgcctg cattggaggc ccgcccaaca tctgcctaga tcggctagaa aactggataa   1020

cgtcattagc agaatctcaa cttcagaccc gtcaacaaat taagaaactg gaggagttgc   1080

agcaaaaagt ttcctacaaa ggggacccca ttgtacagca ccggccgatg ctggaggaga   1140

gaatcgtgga gctgtttaga aacttaatga aaagtgcctt tgtggtggag cggcagccct   1200

gcatgcccat gcatcctgac cggcccctcg tcatcaagac cggcgtccag ttcactacta   1260

aagtcaggtt gctggtcaaa ttccctgagt tgaattatca gcttaaaatt aaagtgtgca   1320

ttgacaaaga ctctggggac gttgcagctc tcagaggatc ccggaaattt aacattctgg   1380

gcacaaacac aaaagtgatg aacatggaag aatccaacaa cggcagcctc tctgcagaat   1440

tcaaacactt gaccctgagg gagcagagat gtgggaatgg gggccgagcc aattgtgatg   1500

cttccctgat tgtgactgag gagctgcacc tgatcacctt tgagaccgag gtgtatcacc   1560

aaggcctcaa gattgaccta gagacccact ccttgccagt tgtggtgatc tccaacatct   1620

gtcagatgcc aaatgcctgg gcgtccatcc tgtggtacaa catgctgacc aacaatccca   1680

agaatgtaaa cttttttacc aagcccccaa ttggaacctg ggatcaagtg gccgaggtcc   1740

tgagctggca gttctcctcc accaccaagc gaggactgag catcgagcag ctgactacac   1800

tggcagagaa actcttggga cctggtgtga attattcagg gtgtcagatc acatgggcta   1860

aattttgcaa agaaaacatg gctggcaagg gcttctcctt ctgggtctgg ctggacaata   1920

tcattgacct tgtgaaaaag tacatcctgg ccctttggaa cgaagggtac atcatgggct   1980

ttatcagtaa ggagcgggag cgggccatct tgagcactaa gcctccaggc accttcctgc   2040

taagattcag tgaaagcagc aaagaaggag gcgtcacttt cacttgggtg gagaaggaca   2100

tcagcggtaa gacccagatc cagtccgtgg aaccatacac aaagcagcag ctgaacaaca   2160

tgtcatttgc tgaaatcatc atgggctata agatcatgga tgctaccaat atcctggtgt   2220

ctccactggt ctatctctat cctgacattc ccaaggagga ggcattcgga aagtattgtc   2280

ggccagagag ccaggagcat cctgaagctg acccaggcgc tgccccatac ctgaagacca   2340

agtttatctg tgtgacacca acgacctgca gcaataccat tgacctgccg atgtcccccc   2400

gcactttaga ttcattgatg cagtttggaa ataatggtga aggtgctgaa ccctcagcag   2460

gagggcagtt tgagtccctc acctttgaca tggagttgac ctcggagtgc gctacctccc   2520

ccatgtgagg agctgagaac ggaagctgca gaaagatacg actgaggcgc ctacctgcat   2580

tctgccaccc ctcacacagc caaaccccag atcatctgaa actactaact ttgtggttcc   2640

agattttttt taatctccta cttctgctat ctttgagcaa tctgggcact tttaaaaata   2700

gagaaatgag tgaatgtggg tgatctgctt ttatctaaat gcaaataagg atgtgttctc   2760

tgagacccat gatcagggga tgtggcgggg ggtggctaga gggagaaaaa ggaaatgtct   2820

tgtgttgttt tgttcccctg ccctcctttc tcagcagctt tttgttattg ttgttgttgt   2880

tcttagacaa gtgcctcctg gtgcctgcgg catccttctg cctgtttctg taagcaaatg   2940

ccacaggcca cctatagcta catactcctg gcattgcact ttttaacctt gctgacatcc   3000

aaatagaaga taggactatc taagccctag gtttcttttt aaattaagaa ataataacaa   3060

ttaaagggca aaaaacactg tatcagcata gcctttctgt atttaagaaa cttaagcagc   3120

cgggcatggt ggctcacgcc tgtaatccca gcactttggg aggccgaggc ggatcataag   3180

gtcaggagat caagaccatc ctggctaaca cggtgaaacc ccgtctctac taaaagtaca   3240

aaaaattagc tgggtgtggt ggtgggcgcc tgtagtccca gctactcggg aggctgaggc   3300

aggagaatcg cttgaacctg agaggcggag gttgcagtga gccaaaattg caccactgca   3360

cactgcactc catcctgggc gacagtctga gactctgtct caaaaaaaaa aaaaaaaaaa   3420

agaaacttca gttaacagcc tccttggtgc tttaagcatt cagcttcctt caggctggta   3480

atttatataa tccctgaaac gggcttcagg tcaaaccctt aagacatctg aagctgcaac   3540

ctggcctttg gtgttgaaat aggaaggttt aaggagaatc taagcatttt agactttttt   3600

ttataaatag acttattttc ctttgtaatg tattggcctt ttagtgagta aggctgggca   3660

gagggtgctt acaaccttga ctccctttct ccctggactt gatctgctgt ttcagaggct   3720

aggttgtttc tgtgggtgcc ttatcagggc tgggatactt ctgattctgg cttccttcct   3780

gccccaccct cccgacccca gtccccctga tcctgctaga ggcatgtctc cttgcgtgtc   3840

taaaggtccc tcatcctgtt tgttttagga atcctggtct caggacctca tggaagaaga   3900

gggggagaga gttacaggtt ggacatgatg cacactatgg ggccccagcg acgtgtctgg   3960

ttgagctcag ggaatatggt tcttagccag tttcttggtg atatccagtg gcacttgtaa   4020

tggcgtcttc attcagttca tgcagggcaa aggcttactg ataaacttga gtctgccctc   4080

gtatgagggt gtatacctgg cctccctctg aggctggtga ctcctccctg ctggggcccc   4140

acaggtgagg cagaacagct agagggcctc cccgcctgcc cgccttggct ggctagctcg   4200

cctctcctgt gcgtatggga acacctagca cgtgctggat gggctgcctc tgactcagag   4260

gcatggccgg atttggcaac tcaaaaccac cttgcctcag ctgatcagag tttctgtgga   4320

attctgtttg ttaaatcaaa ttagctggtc tctgaattaa gggggagacg accttctcta   4380

agatgaacag ggttcgcccc agtcctcctg cctggagaca gttgatgtgt catgcagagc   4440

tcttacttct ccagcaacac tcttcagtac ataataagct taactgataa acagaatatt   4500

tagaaaggtg agacttgggc ttaccattgg gtttaaatca tagggaccta gggcgagggt   4560

tcagggcttc tctggagcag atattgtcaa gttcatggcc ttaggtagca tgtatctggt   4620

cttaactctg attgtagcaa aagttctgag aggagctgag ccctgttgtg gcccattaaa   4680

gaacagggtc ctcaggccct gcccgcttcc tgtccactgc cccctcccca tccccagccc   4740

agccgaggga atcccgtggg ttgcttacct acctataagg tggtttataa gctgctgtcc   4800

tggccactgc attcaaattc caatgtgtac ttcatagtgt aaaaatttat attattgtga   4860

ggttttttgt cttttttttt tttttttttt tttggtatat tgctgtatct actttaactt   4920

ccagaaataa acgttatata ggaaccgtaa aaa                                4953


<210>  3477
<211>  769
<212>  PRT
<213>  Homosapiens

<400>  3477

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ala Ala Pro Tyr 
    690                 695                 700                 


Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn Thr 
705                 710                 715                 720 


Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln Phe 
                725                 730                 735     


Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe Glu 
            740                 745                 750         


Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser Pro 
        755                 760                 765             


Met 
    


<210>  3478
<211>  4978
<212>  DNA
<213>  Homosapiens

<400>  3478
ggtttccgga gctgcggcgg cgcagactgg gagggggagc cgggggttcc gacgtcgcag     60

ccgagggaac aagccccaac cggatcctgg acaggcaccc cggcttggcg ctgtctctcc    120

ccctcggctc ggagaggccc ttcggcctga gggagcctcg ccgcccgtcc ccggcacacg    180

cgcagccccg gcctctcggc ctctgccgga gaaacagttg ggacccctga ttttagcagg    240

atggcccaat ggaatcagct acagcagctt gacacacggt acctggagca gctccatcag    300

ctctacagtg acagcttccc aatggagctg cggcagtttc tggccccttg gattgagagt    360

caagattggg catatgcggc cagcaaagaa tcacatgcca ctttggtgtt tcataatctc    420

ctgggagaga ttgaccagca gtatagccgc ttcctgcaag agtcgaatgt tctctatcag    480

cacaatctac gaagaatcaa gcagtttctt cagagcaggt atcttgagaa gccaatggag    540

attgcccgga ttgtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc    600

actgcggccc agcaaggggg ccaggccaac caccccacag cagccgtggt gacggagaag    660

cagcagatgc tggagcagca ccttcaggat gtccggaaga gagtgcagga tctagaacag    720

aaaatgaaag tggtagagaa tctccaggat gactttgatt tcaactataa aaccctcaag    780

agtcaaggag acatgcaaga tctgaatgga aacaaccagt cagtgaccag gcagaagatg    840

cagcagctgg aacagatgct cactgcgctg gaccagatgc ggagaagcat cgtgagtgag    900

ctggcggggc ttttgtcagc gatggagtac gtgcagaaaa ctctcacgga cgaggagctg    960

gctgactgga agaggcggca acagattgcc tgcattggag gcccgcccaa catctgccta   1020

gatcggctag aaaactggat aacgtcatta gcagaatctc aacttcagac ccgtcaacaa   1080

attaagaaac tggaggagtt gcagcaaaaa gtttcctaca aaggggaccc cattgtacag   1140

caccggccga tgctggagga gagaatcgtg gagctgttta gaaacttaat gaaaagtgcc   1200

tttgtggtgg agcggcagcc ctgcatgccc atgcatcctg accggcccct cgtcatcaag   1260

accggcgtcc agttcactac taaagtcagg ttgctggtca aattccctga gttgaattat   1320

cagcttaaaa ttaaagtgtg cattgacaaa gactctgggg acgttgcagc tctcagagga   1380

tcccggaaat ttaacattct gggcacaaac acaaaagtga tgaacatgga agaatccaac   1440

aacggcagcc tctctgcaga attcaaacac ttgaccctga gggagcagag atgtgggaat   1500

gggggccgag ccaattgtga tgcttccctg attgtgactg aggagctgca cctgatcacc   1560

tttgagaccg aggtgtatca ccaaggcctc aagattgacc tagagaccca ctccttgcca   1620

gttgtggtga tctccaacat ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac   1680

aacatgctga ccaacaatcc caagaatgta aactttttta ccaagccccc aattggaacc   1740

tgggatcaag tggccgaggt cctgagctgg cagttctcct ccaccaccaa gcgaggactg   1800

agcatcgagc agctgactac actggcagag aaactcttgg gacctggtgt gaattattca   1860

gggtgtcaga tcacatgggc taaattttgc aaagaaaaca tggctggcaa gggcttctcc   1920

ttctgggtct ggctggacaa tatcattgac cttgtgaaaa agtacatcct ggccctttgg   1980

aacgaagggt acatcatggg ctttatcagt aaggagcggg agcgggccat cttgagcact   2040

aagcctccag gcaccttcct gctaagattc agtgaaagca gcaaagaagg aggcgtcact   2100

ttcacttggg tggagaagga catcagcggt aagacccaga tccagtccgt ggaaccatac   2160

acaaagcagc agctgaacaa catgtcattt gctgaaatca tcatgggcta taagatcatg   2220

gatgctacca atatcctggt gtctccactg gtctatctct atcctgacat tcccaaggag   2280

gaggcattcg gaaagtattg tcggccagag agccaggagc atcctgaagc tgacccaggt   2340

agcgctgccc catacctgaa gaccaagttt atctgtgtga caccaacgac ctgcagcaat   2400

accattgacc tgccgatgtc cccccgcact ttagattcat tgatgcagtt tggaaataat   2460

ggtgaaggtg ctgaaccctc agcaggaggg cagtttgagt ccctcacctt tgacatggag   2520

ttgacctcgg agtgcgctac ctcccccatg tgaggagctg agaacggaag ctgcagaaag   2580

atacgactga ggcgcctacc tgcattctgc cacccctcac acagccaaac cccagatcat   2640

ctgaaactac taactttgtg gttccagatt ttttttaatc tcctacttct gctatctttg   2700

agcaatctgg gcacttttaa aaatagagaa atgagtgaat gtgggtgatc tgcttttatc   2760

taaatgcaaa taaggatgtg ttctctgaga cccatgatca ggggatgtgg cggggggtgg   2820

ctagagggag aaaaaggaaa tgtcttgtgt tgttttgttc ccctgccctc ctttctcagc   2880

agctttttgt tattgttgtt gttgttctta gacaagtgcc tcctggtgcc tgcggcatcc   2940

ttctgcctgt ttctgtaagc aaatgccaca ggccacctat agctacatac tcctggcatt   3000

gcacttttta accttgctga catccaaata gaagatagga ctatctaagc cctaggtttc   3060

tttttaaatt aagaaataat aacaattaaa gggcaaaaaa cactgtatca gcatagcctt   3120

tctgtattta agaaacttaa gcagccgggc atggtggctc acgcctgtaa tcccagcact   3180

ttgggaggcc gaggcggatc ataaggtcag gagatcaaga ccatcctggc taacacggtg   3240

aaaccccgtc tctactaaaa gtacaaaaaa ttagctgggt gtggtggtgg gcgcctgtag   3300

tcccagctac tcgggaggct gaggcaggag aatcgcttga acctgagagg cggaggttgc   3360

agtgagccaa aattgcacca ctgcacactg cactccatcc tgggcgacag tctgagactc   3420

tgtctcaaaa aaaaaaaaaa aaaaaagaaa cttcagttaa cagcctcctt ggtgctttaa   3480

gcattcagct tccttcaggc tggtaattta tataatccct gaaacgggct tcaggtcaaa   3540

cccttaagac atctgaagct gcaacctggc ctttggtgtt gaaataggaa ggtttaagga   3600

gaatctaagc attttagact tttttttata aatagactta ttttcctttg taatgtattg   3660

gccttttagt gagtaaggct gggcagaggg tgcttacaac cttgactccc tttctccctg   3720

gacttgatct gctgtttcag aggctaggtt gtttctgtgg gtgccttatc agggctggga   3780

tacttctgat tctggcttcc ttcctgcccc accctcccga ccccagtccc cctgatcctg   3840

ctagaggcat gtctccttgc gtgtctaaag gtccctcatc ctgtttgttt taggaatcct   3900

ggtctcagga cctcatggaa gaagaggggg agagagttac aggttggaca tgatgcacac   3960

tatggggccc cagcgacgtg tctggttgag ctcagggaat atggttctta gccagtttct   4020

tggtgatatc cagtggcact tgtaatggcg tcttcattca gttcatgcag ggcaaaggct   4080

tactgataaa cttgagtctg ccctcgtatg agggtgtata cctggcctcc ctctgaggct   4140

ggtgactcct ccctgctggg gccccacagg tgaggcagaa cagctagagg gcctccccgc   4200

ctgcccgcct tggctggcta gctcgcctct cctgtgcgta tgggaacacc tagcacgtgc   4260

tggatgggct gcctctgact cagaggcatg gccggatttg gcaactcaaa accaccttgc   4320

ctcagctgat cagagtttct gtggaattct gtttgttaaa tcaaattagc tggtctctga   4380

attaaggggg agacgacctt ctctaagatg aacagggttc gccccagtcc tcctgcctgg   4440

agacagttga tgtgtcatgc agagctctta cttctccagc aacactcttc agtacataat   4500

aagcttaact gataaacaga atatttagaa aggtgagact tgggcttacc attgggttta   4560

aatcataggg acctagggcg agggttcagg gcttctctgg agcagatatt gtcaagttca   4620

tggccttagg tagcatgtat ctggtcttaa ctctgattgt agcaaaagtt ctgagaggag   4680

ctgagccctg ttgtggccca ttaaagaaca gggtcctcag gccctgcccg cttcctgtcc   4740

actgccccct ccccatcccc agcccagccg agggaatccc gtgggttgct tacctaccta   4800

taaggtggtt tataagctgc tgtcctggcc actgcattca aattccaatg tgtacttcat   4860

agtgtaaaaa tttatattat tgtgaggttt tttgtctttt tttttttttt ttttttttgg   4920

tatattgctg tatctacttt aacttccaga aataaacgtt atataggaac cgtaaaaa     4978


<210>  3479
<211>  770
<212>  PRT
<213>  Homosapiens

<400>  3479

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


<210>  3480
<211>  4819
<212>  DNA
<213>  Homosapiens

<400>  3480
cgctgtctct ccccctcggc tcggagaggc ccttcggcct gagggagcct cgccgcccgt     60

ccccggcaca cgcgcagccc cggcctctcg gcctctgccg gagaaacagt tgggacccct    120

gattttagca ggatggccca atggaatcag ctacagcagc ttgacacacg gtacctggag    180

cagctccatc agctctacag tgacagcttc ccaatggagc tgcggcagtt tctggcccct    240

tggattgaga gtcaagattg ggcatatgcg gccagcaaag aatcacatgc cactttggtg    300

tttcataatc tcctgggaga gattgaccag cagtatagcc gcttcctgca agagtcgaat    360

gttctctatc agcacaatct acgaagaatc aagcagtttc ttcagagcag gtatcttgag    420

aagccaatgg agattgcccg gattgtggcc cggtgcctgt gggaagaatc acgccttcta    480

cagactgcag ccactgcggc ccagcaaggg ggccaggcca accaccccac agcagccgtg    540

gtgacggaga agcagcagat gctggagcag caccttcagg atgtccggaa gagagtgcag    600

gatctagaac agaaaatgaa agtggtagag aatctccagg atgactttga tttcaactat    660

aaaaccctca agagtcaagg agacatgcaa gatctgaatg gaaacaacca gtcagtgacc    720

aggcagaaga tgcagcagct ggaacagatg ctcactgcgc tggaccagat gcggagaagc    780

atcgtgagtg agctggcggg gcttttgtca gcgatggagt acgtgcagaa aactctcacg    840

gacgaggagc tggctgactg gaagaggcgg caacagattg cctgcattgg aggcccgccc    900

aacatctgcc tagatcggct agaaaactgg ataacgtcat tagcagaatc tcaacttcag    960

acccgtcaac aaattaagaa actggaggag ttgcagcaaa aagtttccta caaaggggac   1020

cccattgtac agcaccggcc gatgctggag gagagaatcg tggagctgtt tagaaactta   1080

atgaaaagtg cctttgtggt ggagcggcag ccctgcatgc ccatgcatcc tgaccggccc   1140

ctcgtcatca agaccggcgt ccagttcact actaaagtca ggttgctggt caaattccct   1200

gagttgaatt atcagcttaa aattaaagtg tgcattgaca aagactctgg ggacgttgca   1260

gctctcagag gatcccggaa atttaacatt ctgggcacaa acacaaaagt gatgaacatg   1320

gaagaatcca acaacggcag cctctctgca gaattcaaac acttgaccct gagggagcag   1380

agatgtggga atgggggccg agccaattgt gatgcttccc tgattgtgac tgaggagctg   1440

cacctgatca cctttgagac cgaggtgtat caccaaggcc tcaagattga cctagagacc   1500

cactccttgc cagttgtggt gatctccaac atctgtcaga tgccaaatgc ctgggcgtcc   1560

atcctgtggt acaacatgct gaccaacaat cccaagaatg taaacttttt taccaagccc   1620

ccaattggaa cctgggatca agtggccgag gtcctgagct ggcagttctc ctccaccacc   1680

aagcgaggac tgagcatcga gcagctgact acactggcag agaaactctt gggacctggt   1740

gtgaattatt cagggtgtca gatcacatgg gctaaatttt gcaaagaaaa catggctggc   1800

aagggcttct ccttctgggt ctggctggac aatatcattg accttgtgaa aaagtacatc   1860

ctggcccttt ggaacgaagg gtacatcatg ggctttatca gtaaggagcg ggagcgggcc   1920

atcttgagca ctaagcctcc aggcaccttc ctgctaagat tcagtgaaag cagcaaagaa   1980

ggaggcgtca ctttcacttg ggtggagaag gacatcagcg gtaagaccca gatccagtcc   2040

gtggaaccat acacaaagca gcagctgaac aacatgtcat ttgctgaaat catcatgggc   2100

tataagatca tggatgctac caatatcctg gtgtctccac tggtctatct ctatcctgac   2160

attcccaagg aggaggcatt cggaaagtat tgtcggccag agagccagga gcatcctgaa   2220

gctgacccag gtagcgctgc cccatacctg aagaccaagt ttatctgtgt gacaccattc   2280

attgatgcag tttggaaata atggtgaagg tgctgaaccc tcagcaggag ggcagtttga   2340

gtccctcacc tttgacatgg agttgacctc ggagtgcgct acctccccca tgtgaggagc   2400

tgagaacgga agctgcagaa agatacgact gaggcgccta cctgcattct gccacccctc   2460

acacagccaa accccagatc atctgaaact actaactttg tggttccaga ttttttttaa   2520

tctcctactt ctgctatctt tgagcaatct gggcactttt aaaaatagag aaatgagtga   2580

atgtgggtga tctgctttta tctaaatgca aataaggatg tgttctctga gacccatgat   2640

caggggatgt ggcggggggt ggctagaggg agaaaaagga aatgtcttgt gttgttttgt   2700

tcccctgccc tcctttctca gcagcttttt gttattgttg ttgttgttct tagacaagtg   2760

cctcctggtg cctgcggcat ccttctgcct gtttctgtaa gcaaatgcca caggccacct   2820

atagctacat actcctggca ttgcactttt taaccttgct gacatccaaa tagaagatag   2880

gactatctaa gccctaggtt tctttttaaa ttaagaaata ataacaatta aagggcaaaa   2940

aacactgtat cagcatagcc tttctgtatt taagaaactt aagcagccgg gcatggtggc   3000

tcacgcctgt aatcccagca ctttgggagg ccgaggcgga tcataaggtc aggagatcaa   3060

gaccatcctg gctaacacgg tgaaaccccg tctctactaa aagtacaaaa aattagctgg   3120

gtgtggtggt gggcgcctgt agtcccagct actcgggagg ctgaggcagg agaatcgctt   3180

gaacctgaga ggcggaggtt gcagtgagcc aaaattgcac cactgcacac tgcactccat   3240

cctgggcgac agtctgagac tctgtctcaa aaaaaaaaaa aaaaaaaaga aacttcagtt   3300

aacagcctcc ttggtgcttt aagcattcag cttccttcag gctggtaatt tatataatcc   3360

ctgaaacggg cttcaggtca aacccttaag acatctgaag ctgcaacctg gcctttggtg   3420

ttgaaatagg aaggtttaag gagaatctaa gcattttaga ctttttttta taaatagact   3480

tattttcctt tgtaatgtat tggcctttta gtgagtaagg ctgggcagag ggtgcttaca   3540

accttgactc cctttctccc tggacttgat ctgctgtttc agaggctagg ttgtttctgt   3600

gggtgcctta tcagggctgg gatacttctg attctggctt ccttcctgcc ccaccctccc   3660

gaccccagtc cccctgatcc tgctagaggc atgtctcctt gcgtgtctaa aggtccctca   3720

tcctgtttgt tttaggaatc ctggtctcag gacctcatgg aagaagaggg ggagagagtt   3780

acaggttgga catgatgcac actatggggc cccagcgacg tgtctggttg agctcaggga   3840

atatggttct tagccagttt cttggtgata tccagtggca cttgtaatgg cgtcttcatt   3900

cagttcatgc agggcaaagg cttactgata aacttgagtc tgccctcgta tgagggtgta   3960

tacctggcct ccctctgagg ctggtgactc ctccctgctg gggccccaca ggtgaggcag   4020

aacagctaga gggcctcccc gcctgcccgc cttggctggc tagctcgcct ctcctgtgcg   4080

tatgggaaca cctagcacgt gctggatggg ctgcctctga ctcagaggca tggccggatt   4140

tggcaactca aaaccacctt gcctcagctg atcagagttt ctgtggaatt ctgtttgtta   4200

aatcaaatta gctggtctct gaattaaggg ggagacgacc ttctctaaga tgaacagggt   4260

tcgccccagt cctcctgcct ggagacagtt gatgtgtcat gcagagctct tacttctcca   4320

gcaacactct tcagtacata ataagcttaa ctgataaaca gaatatttag aaaggtgaga   4380

cttgggctta ccattgggtt taaatcatag ggacctaggg cgagggttca gggcttctct   4440

ggagcagata ttgtcaagtt catggcctta ggtagcatgt atctggtctt aactctgatt   4500

gtagcaaaag ttctgagagg agctgagccc tgttgtggcc cattaaagaa cagggtcctc   4560

aggccctgcc cgcttcctgt ccactgcccc ctccccatcc ccagcccagc cgagggaatc   4620

ccgtgggttg cttacctacc tataaggtgg tttataagct gctgtcctgg ccactgcatt   4680

caaattccaa tgtgtacttc atagtgtaaa aatttatatt attgtgaggt tttttgtctt   4740

tttttttttt tttttttttt ggtatattgc tgtatctact ttaacttcca gaaataaacg   4800

ttatatagga accgtaaaa                                                4819


<210>  3481
<211>  722
<212>  PRT
<213>  Homosapiens

<400>  3481

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Phe Ile Asp Ala Val 
705                 710                 715                 720 


Trp Lys 
        


<210>  3482
<211>  3580
<212>  DNA
<213>  Homosapiens

<400>  3482
agttctggcc gctgtcccgg tgcgcacgga cgtggctcga gtttcctctg ctctccgctc     60

tcgcccgcta gctctcctcc cttccgctcc tgcttctctc cgggtctccc gctccagctc    120

cagccccacc cggccggtcc cgcacggctc cgggtagcca tggaggaccc cacgctctat    180

attgtcgagc ggccgcttcc cgggtacccc gacgccgagg ccccggagcc ttcctccgct    240

ggggctcagg cagcggagga gccgtcgggg gccggctcag aagagctgat caagtcggac    300

caggtgaacg gcgtgctggt gctgagcctc ctggacaaaa tcatcggggc cgtagaccag    360

atccagctga ctcaagcaca gctggaggag cggcaggcgg agatggaggg cgcagtgcag    420

agcatccagg gcgagctgag caagctgggc aaggcgcacg ccaccacgag caatacggtg    480

agcaagctgc tggagaaggt gcgcaaggtc agcgtcaacg tgaagaccgt gcgcggcagc    540

ctggagcgcc aggcggggca gatcaagaag ctggaggtca acgaggccga gctgctgcgg    600

cgccgcaact ttaaagtcat gatctaccag gatgaagtga agctgccggc caaactgagc    660

atcagcaaat cgctgaaaga gtcggaggcg ctgccagaga aggagggcga ggagctgggc    720

gagggcgagc ggcccgagga ggacgcagcg gcgctggagc tttcgtcgga cgaggcggtg    780

gaggttgagg aggttattga ggagtcccgc gcagagcgta tcaagcgcag cggcctgcgg    840

cgcgtggacg acttcaagaa ggccttctcc aaggagaaga tggagaagac caaggtgcgt    900

acccgcgaga acctggagaa gacgcgcctc aagaccaagg aaaacctgga gaagacgcgg    960

cacaccctgg agaagcgcat gaacaagctg ggcacgcgcc tggtgcccgc cgagcggcgc   1020

gagaaactga agacgtcgcg agacaagttg cgcaaatcct tcacgcccga ccacgtggtg   1080

tacgcgcgct ccaagaccgc ggtctacaag gtgccaccct tcaccttcca cgtcaagaag   1140

atccgcgagg gccaggtgga agtgctcaag gccaccgaga tggtggaggt gggcgccgac   1200

gacgacgagg gcggcgcgga gcgcggggag gccggcgacc tgcggcgcgg gagcagcccc   1260

gacgtgcacg cgctgctgga gatcaccgag gagtcggacg ccgtgctggt ggacaagagc   1320

gacagcgact gagccgcccc cgctgccacc caccccattc ctcgctcctt ccgaacttcc   1380

tctttcgcat tctctctcgg ctcgagctgg ctgagatttt tctaaattga aaacacgccc   1440

ccctccccac acctccagga actccactcc cagtcttaga gctgttagga cccgatgggg   1500

aggcagcccc cgcagtggac agcccccgct tggacacagt ccgagtggaa tgggaaggga   1560

atggtcaatc cctgtcctgg ttgtccaagt cgggatctca gaggaaattg cagtgattcc   1620

acggttaggc ccccctgggg gggctgcctt cccctcagcc tctccccaca ccacccaccc   1680

agctgctgtc attccgctca ctgagctctt cttcattctc accctgatcc ctgggggact   1740

caaagccaaa actgcccaaa gaggaaagat tgaatcctaa aggggatcct tgcccccatg   1800

ggaggccccc tactagaagg acgtgaaagc agcttttggg ggaaactgag gcagtgggga   1860

agacagagca gaatgagccc tcaccctggc tgggggtcca gcacaggctg tatctgcaga   1920

gggtcccaga ggaacgctgg agccaagaga agccctggga aggaggggtg gggaacgaca   1980

tgcatgtgag ggatggcaca ctgatgtgtt tatgcacctg tacacaggag cgcatggcca   2040

tggctttgga aaggagaatg gaaaaataga agaaggtcgg ccgggcttgg tggcttaagc   2100

ctgtaacccc agcactttgg gaggccgagg tgggcggatc acctgaggtc aggagttcgg   2160

gaccagcctg gcaaacaccc catctctact aagcgaaaac ccatctctac taaaattaca   2220

aaaattagct gggcatggtt gcgcatgcct gtaatcccag ctactttgga ggctgaggtg   2280

gggagaattg cttgaacctg ggaggtggag gttgcagtga gccaaggtcg cgacactgca   2340

ctccagcctg ggtgacagag tgagactcca tctcaacaga aggaaaaaaa aggaaaatag   2400

gagaaggtgg aaatgggtga agagagaagt cccctcacta gctgcatgag aaatctatct   2460

tactgtggtt ctccatgggc agcaggacca tttttcagaa tcaagaggga ggacagtgtg   2520

agaaggcgat gatccaaaga agacagagag gtcagcccca cccgatccct caaatgggct   2580

cttggaggca cccccagggg cagcccattt ctcaaagtcc agaaaattag ggtcccagaa   2640

gggggcagca gcaggctggg agttaggagg gagagcaggg tgccggccct gccaccaagt   2700

tgagagctgg aggggaggtg gggagagaac atcacagagc agccagccct ggttcactcc   2760

tggcagtttc ttctcaagct ccttccctag gagcatggtg gcacgtgcct gtggtctcag   2820

ctacttggga ggctgaggcg ggaggatcgc cagagcccag gagtttgagg ctgcagtgag   2880

ctatgagggt gcctctgtgc tccatcctag gcaacagagt gagacgctgt ttaaaaagga   2940

aaaaatcctt ccctagagct agtatcctaa agctgcagag ctagcccaga cctcattggt   3000

ttccttgtcc ttggggtgct tttcctgaat ctttgggggt gaagggagtg ttgctcccag   3060

tccagaggcc tgattctgtt cggactgggt tctcaagaca cgaccaggtt ctcaagacac   3120

gagtcccctt gttcctcccc attaaagggg gtttgtcaga agcaagaaca gcccctctcc   3180

ccagtcacag cctgaaggga ggccccgaga gcttcctcct tccccccacc tgctccttac   3240

cttctctgcc ctgcttttta gaactgcagt tcattgtttt aagggattgg gggagggagc   3300

ctggggacac aaacctttta tacaatacaa agctttgctt tttttttttt ttttcttcct   3360

tttccctttc tcggttctct tctctcctct gaatggctga agacccctct gccgagggag   3420

gttggggatt gtgggacaag gtcccttggt gctgatggcc tgaaggggcc tgagctgtgg   3480

gcagatgcag ttttctgtgg gcttggggaa cctctcacgt tgctgtgtcc tggtgagcag   3540

cccgaccaat aaacctgctt ttccaaaaaa aaaaaaaaaa                         3580


<210>  3483
<211>  390
<212>  PRT
<213>  Homosapiens

<400>  3483

Met Glu Asp Pro Thr Leu Tyr Ile Val Glu Arg Pro Leu Pro Gly Tyr 
1               5                   10                  15      


Pro Asp Ala Glu Ala Pro Glu Pro Ser Ser Ala Gly Ala Gln Ala Ala 
            20                  25                  30          


Glu Glu Pro Ser Gly Ala Gly Ser Glu Glu Leu Ile Lys Ser Asp Gln 
        35                  40                  45              


Val Asn Gly Val Leu Val Leu Ser Leu Leu Asp Lys Ile Ile Gly Ala 
    50                  55                  60                  


Val Asp Gln Ile Gln Leu Thr Gln Ala Gln Leu Glu Glu Arg Gln Ala 
65                  70                  75                  80  


Glu Met Glu Gly Ala Val Gln Ser Ile Gln Gly Glu Leu Ser Lys Leu 
                85                  90                  95      


Gly Lys Ala His Ala Thr Thr Ser Asn Thr Val Ser Lys Leu Leu Glu 
            100                 105                 110         


Lys Val Arg Lys Val Ser Val Asn Val Lys Thr Val Arg Gly Ser Leu 
        115                 120                 125             


Glu Arg Gln Ala Gly Gln Ile Lys Lys Leu Glu Val Asn Glu Ala Glu 
    130                 135                 140                 


Leu Leu Arg Arg Arg Asn Phe Lys Val Met Ile Tyr Gln Asp Glu Val 
145                 150                 155                 160 


Lys Leu Pro Ala Lys Leu Ser Ile Ser Lys Ser Leu Lys Glu Ser Glu 
                165                 170                 175     


Ala Leu Pro Glu Lys Glu Gly Glu Glu Leu Gly Glu Gly Glu Arg Pro 
            180                 185                 190         


Glu Glu Asp Ala Ala Ala Leu Glu Leu Ser Ser Asp Glu Ala Val Glu 
        195                 200                 205             


Val Glu Glu Val Ile Glu Glu Ser Arg Ala Glu Arg Ile Lys Arg Ser 
    210                 215                 220                 


Gly Leu Arg Arg Val Asp Asp Phe Lys Lys Ala Phe Ser Lys Glu Lys 
225                 230                 235                 240 


Met Glu Lys Thr Lys Val Arg Thr Arg Glu Asn Leu Glu Lys Thr Arg 
                245                 250                 255     


Leu Lys Thr Lys Glu Asn Leu Glu Lys Thr Arg His Thr Leu Glu Lys 
            260                 265                 270         


Arg Met Asn Lys Leu Gly Thr Arg Leu Val Pro Ala Glu Arg Arg Glu 
        275                 280                 285             


Lys Leu Lys Thr Ser Arg Asp Lys Leu Arg Lys Ser Phe Thr Pro Asp 
    290                 295                 300                 


His Val Val Tyr Ala Arg Ser Lys Thr Ala Val Tyr Lys Val Pro Pro 
305                 310                 315                 320 


Phe Thr Phe His Val Lys Lys Ile Arg Glu Gly Gln Val Glu Val Leu 
                325                 330                 335     


Lys Ala Thr Glu Met Val Glu Val Gly Ala Asp Asp Asp Glu Gly Gly 
            340                 345                 350         


Ala Glu Arg Gly Glu Ala Gly Asp Leu Arg Arg Gly Ser Ser Pro Asp 
        355                 360                 365             


Val His Ala Leu Leu Glu Ile Thr Glu Glu Ser Asp Ala Val Leu Val 
    370                 375                 380                 


Asp Lys Ser Asp Ser Asp 
385                 390 


<210>  3484
<211>  4187
<212>  DNA
<213>  Homosapiens

<400>  3484
ggcggcgcag gggcggggct ttacggacgc aagcacgtcg aagcgctgct cctggagccg     60

cggagggtgc gggtttggct gcggtggttt ctgtggcggt tgctgtggcg gagtttggag    120

gttggagaga aatccaggta ctcactagac tggtaccttc tgccaccatg ggggagcttt    180

tccggagtga agaaatgaca ctggcccagc tttttctaca gtcagaggct gcttattgtt    240

gtgtcagtga attaggagaa cttggaaagg ttcagtttcg tgacttaaat ccagatgtga    300

atgttttcca acggaaattt gtgaatgaag ttagaagatg tgaagaaatg gatcgaaagc    360

ttcgatttgt tgagaaagag ataagaaaag ctaacattcc gattatggac accggtgaaa    420

acccagaggt tcccttcccc cgggacatga ttgacttaga ggccaatttt gagaagattg    480

aaaatgaact gaaggaaatc aacacaaacc aggaagctct gaagagaaac ttcctggaac    540

tgaccgaatt aaaatttata cttcgcaaaa ctcagcaatt ttttgatgag atggcggatc    600

cagacttgtt ggaagagtcc tcatccctct tggagccaag tgagatggga agaggcactc    660

ctttaagact tggcttcgtg gctggtgtca ttaaccggga gcgcatccct acttttgagc    720

gcatgctttg gcgggtatgc cggggaaatg tgttcctgcg acaggctgaa atcgagaacc    780

ccctggagga tcctgtgact ggcgactacg tgcacaagtc tgtgtttatc attttcttcc    840

aaggcgatca gctgaaaaac agagtcaaga aaatctgtga agggttccga gcctcactct    900

atccctgtcc tgagacacca caggagagga aggaaatggc ttctggagtg aataccagga    960

ttgatgatct ccaaatggtt ctgaatcaaa cggaggatca ccgccagagg gttctgcagg   1020

cagctgctaa gaacatccgt gtctggttca tcaaagtgcg gaagatgaag gccatctatc   1080

acaccctgaa cctgtgcaac atagatgtga ctcagaaatg cttgattgca gaggtctggt   1140

gccctgtcac cgaccttgac tccatccagt ttgcactcag aaggggcacg gaacacagtg   1200

gttccactgt accttccatt ttgaacagga tgcagacaaa ccagactccc ccaacctata   1260

acaaaaccaa caagtttacc tatggctttc agaacatagt agatgcttat ggaattggaa   1320

cttaccgaga gataaatcca gctccgtata ctattatcac gttccctttt ctatttgctg   1380

tgatgtttgg agacttcggt catggcattt taatgaccct ttttgctgtg tggatggtac   1440

tgagggagag ccggatcctt tcccagaaga atgagaatga gatgtttagc actgtgttca   1500

gtggtcgata cattatttta ttgatgggtg tgttctccat gtacactggc ctcatctaca   1560

atgattgctt ttccaagtct cttaatatct ttgggtcatc ctggagtgta cggccgatgt   1620

ttacttataa ttggactgaa gagacgcttc gggggaaccc tgttctacag ctgaacccag   1680

ccctccctgg agtgtttggt ggaccatacc cttttggcat tgatccaatt tggaacattg   1740

ctaccaataa actgacgttc ttgaactcct ttaagatgaa gatgtctgtt atccttggta   1800

tcatccatat gctgtttgga gtcagcctga gtctgttcaa ccatatctat ttcaagaagc   1860

ccctgaatat ctactttgga tttattcctg aaataatctt catgacctct ttgtttggct   1920

atttggttat ccttattttt tacaagtgga cggcctatga tgctcatacc tctgagaatg   1980

caccaagcct tctgatccat ttcataaaca tgttcctctt ttcctaccca gagtctggtt   2040

attcaatgtt gtattctgga cagaaaggaa ttcagtgttt cctggtagtg gttgcactac   2100

tgtgtgtacc ttggatgctg ctgtttaaac cattggtcct tcgccgtcag tatttgagga   2160

gaaagcattt gggaactctc aactttggtg ggatcagggt gggcaacgga ccgacagagg   2220

aggatgctga gattattcag catgaccagc tctccaccca ctcagaggac gcagacgagt   2280

ttgactttgg ggacaccatg gtccaccagg ccatccacac catcgagtac tgcctgggct   2340

gcatctccaa cactgcctcc tacttgcggc tctgggccct cagcctcgct catgcgcagc   2400

tgtctgaggt gctttggacc atggtgatcc acatcggcct gagcgtgaag agcttggcgg   2460

gaggtttggt gctgttcttc ttcttcactg cctttgccac cctgaccgtg gccatcctcc   2520

tgatcatgga gggcctctcg gcctttctcc acgcactgcg cttacactgg gttgagttcc   2580

agaataaatt ctacagcggg accggtttca agttcttacc cttctccttc gagcatattc   2640

gggaagggaa gtttgaagag tgagtccctg tgagggccgt gtgccccatg ctaccctccc   2700

cgcctccctc cacagtgatc agctgtgcct ctctgcctgt tggttgtgat ctgtgggcac   2760

cagctcattc gtgtcaccct gtctgtgagt catttagata gaatagtcct ccttgggtct   2820

cccaccaccc ctagctttgt gtgtagtgta gtgattttct ggctgtcact catactcact   2880

gggcaccagc cttgccctct tagcctccat ccatccagac agcccttccc acctcctggt   2940

ggtgagccag tctgcattcc cacgccatcc caaagccctt tcatcttccc cgtgcattgt   3000

agatggaagg agcacccatg ccattcacat ctagactttg agttccctgc atctgccacc   3060

gtagtttcta gcaggagtag tggggggagt aatacagatt cttccctaga aggggacact   3120

ggtaacatgt cccactcttg gattagcagg ggtgggtcca ggaagatgat atttgcgtct   3180

tttgcccacc cccctggcat tcagctggac ccaactaggc catcatgagt ggcttctccc   3240

tgtcatcccc aggggtcata ggatatctac accgcctttc tgaccccacc ctgcactccc   3300

atcctttcct ctctccccgt tcatgccctg cactacatag cacagccggg atgcttggaa   3360

cagaggcctt ggctgctccg cagtgcacag ggcttccctc tctcggggtt ggcttcttcc   3420

caggccttgc atgggccctg cccacaagca caccctcagg ccgagggtgc agactgatgc   3480

tcttccctga tggagaccct gagatcttcc ccacccccaa tcatgatgtc ttcagtgtgg   3540

gactggggtc ctcttggttc tgcctgcagc ctgcctggct ccgcccctag tgccccctcc   3600

tcaccacact ggccccaggt ctcaggaggg gtgtcctggg cagggaaggt cagtgtcact   3660

gatggtttgc tgtttggaag ccattggcag ggctgccgtg catgtggctg tgagggctgc   3720

acagtcctgc caaggggctt cctccttgtc accccgaacc ttgtaatcgt gtgctggcgt   3780

ggcagccctg gctaagttaa tccccaccgc tttcagtggt agaaagaatt ccctgagtgg   3840

gccaggctgg tgccctcctc ctaccctggc ttttctgagt gagctgcctg gagccctcat   3900

cccctctccc aggctgggct ggccctgggc ggggccactg tgtgctggcc cactgtgacc   3960

tgacccgacc ttgtgcagcc cccctgccct ggtgtcctgg gttttcgtga tgatctttgc   4020

tctgtttcca gtggggtttg aagcagagtt cagggaaccc tgcccaaggt cctcctgttc   4080

agacattcct atgttgaata aagtatgttt gacttccccg gaaaaaaaaa aaaaaaaaaa   4140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 4187


<210>  3485
<211>  831
<212>  PRT
<213>  Homosapiens

<400>  3485

Met Gly Glu Leu Phe Arg Ser Glu Glu Met Thr Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys 
    50                  55                  60                  


Leu Arg Phe Val Glu Lys Glu Ile Arg Lys Ala Asn Ile Pro Ile Met 
65                  70                  75                  80  


Asp Thr Gly Glu Asn Pro Glu Val Pro Phe Pro Arg Asp Met Ile Asp 
                85                  90                  95      


Leu Glu Ala Asn Phe Glu Lys Ile Glu Asn Glu Leu Lys Glu Ile Asn 
            100                 105                 110         


Thr Asn Gln Glu Ala Leu Lys Arg Asn Phe Leu Glu Leu Thr Glu Leu 
        115                 120                 125             


Lys Phe Ile Leu Arg Lys Thr Gln Gln Phe Phe Asp Glu Met Ala Asp 
    130                 135                 140                 


Pro Asp Leu Leu Glu Glu Ser Ser Ser Leu Leu Glu Pro Ser Glu Met 
145                 150                 155                 160 


Gly Arg Gly Thr Pro Leu Arg Leu Gly Phe Val Ala Gly Val Ile Asn 
                165                 170                 175     


Arg Glu Arg Ile Pro Thr Phe Glu Arg Met Leu Trp Arg Val Cys Arg 
            180                 185                 190         


Gly Asn Val Phe Leu Arg Gln Ala Glu Ile Glu Asn Pro Leu Glu Asp 
        195                 200                 205             


Pro Val Thr Gly Asp Tyr Val His Lys Ser Val Phe Ile Ile Phe Phe 
    210                 215                 220                 


Gln Gly Asp Gln Leu Lys Asn Arg Val Lys Lys Ile Cys Glu Gly Phe 
225                 230                 235                 240 


Arg Ala Ser Leu Tyr Pro Cys Pro Glu Thr Pro Gln Glu Arg Lys Glu 
                245                 250                 255     


Met Ala Ser Gly Val Asn Thr Arg Ile Asp Asp Leu Gln Met Val Leu 
            260                 265                 270         


Asn Gln Thr Glu Asp His Arg Gln Arg Val Leu Gln Ala Ala Ala Lys 
        275                 280                 285             


Asn Ile Arg Val Trp Phe Ile Lys Val Arg Lys Met Lys Ala Ile Tyr 
    290                 295                 300                 


His Thr Leu Asn Leu Cys Asn Ile Asp Val Thr Gln Lys Cys Leu Ile 
305                 310                 315                 320 


Ala Glu Val Trp Cys Pro Val Thr Asp Leu Asp Ser Ile Gln Phe Ala 
                325                 330                 335     


Leu Arg Arg Gly Thr Glu His Ser Gly Ser Thr Val Pro Ser Ile Leu 
            340                 345                 350         


Asn Arg Met Gln Thr Asn Gln Thr Pro Pro Thr Tyr Asn Lys Thr Asn 
        355                 360                 365             


Lys Phe Thr Tyr Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly Ile Gly 
    370                 375                 380                 


Thr Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Thr Ile Ile Thr Phe Pro 
385                 390                 395                 400 


Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly His Gly Ile Leu Met 
                405                 410                 415     


Thr Leu Phe Ala Val Trp Met Val Leu Arg Glu Ser Arg Ile Leu Ser 
            420                 425                 430         


Gln Lys Asn Glu Asn Glu Met Phe Ser Thr Val Phe Ser Gly Arg Tyr 
        435                 440                 445             


Ile Ile Leu Leu Met Gly Val Phe Ser Met Tyr Thr Gly Leu Ile Tyr 
    450                 455                 460                 


Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser Trp Ser 
465                 470                 475                 480 


Val Arg Pro Met Phe Thr Tyr Asn Trp Thr Glu Glu Thr Leu Arg Gly 
                485                 490                 495     


Asn Pro Val Leu Gln Leu Asn Pro Ala Leu Pro Gly Val Phe Gly Gly 
            500                 505                 510         


Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Ile Ala Thr Asn Lys 
        515                 520                 525             


Leu Thr Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly 
    530                 535                 540                 


Ile Ile His Met Leu Phe Gly Val Ser Leu Ser Leu Phe Asn His Ile 
545                 550                 555                 560 


Tyr Phe Lys Lys Pro Leu Asn Ile Tyr Phe Gly Phe Ile Pro Glu Ile 
                565                 570                 575     


Ile Phe Met Thr Ser Leu Phe Gly Tyr Leu Val Ile Leu Ile Phe Tyr 
            580                 585                 590         


Lys Trp Thr Ala Tyr Asp Ala His Thr Ser Glu Asn Ala Pro Ser Leu 
        595                 600                 605             


Leu Ile His Phe Ile Asn Met Phe Leu Phe Ser Tyr Pro Glu Ser Gly 
    610                 615                 620                 


Tyr Ser Met Leu Tyr Ser Gly Gln Lys Gly Ile Gln Cys Phe Leu Val 
625                 630                 635                 640 


Val Val Ala Leu Leu Cys Val Pro Trp Met Leu Leu Phe Lys Pro Leu 
                645                 650                 655     


Val Leu Arg Arg Gln Tyr Leu Arg Arg Lys His Leu Gly Thr Leu Asn 
            660                 665                 670         


Phe Gly Gly Ile Arg Val Gly Asn Gly Pro Thr Glu Glu Asp Ala Glu 
        675                 680                 685             


Ile Ile Gln His Asp Gln Leu Ser Thr His Ser Glu Asp Ala Asp Glu 
    690                 695                 700                 


Phe Asp Phe Gly Asp Thr Met Val His Gln Ala Ile His Thr Ile Glu 
705                 710                 715                 720 


Tyr Cys Leu Gly Cys Ile Ser Asn Thr Ala Ser Tyr Leu Arg Leu Trp 
                725                 730                 735     


Ala Leu Ser Leu Ala His Ala Gln Leu Ser Glu Val Leu Trp Thr Met 
            740                 745                 750         


Val Ile His Ile Gly Leu Ser Val Lys Ser Leu Ala Gly Gly Leu Val 
        755                 760                 765             


Leu Phe Phe Phe Phe Thr Ala Phe Ala Thr Leu Thr Val Ala Ile Leu 
    770                 775                 780                 


Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His Ala Leu Arg Leu His 
785                 790                 795                 800 


Trp Val Glu Phe Gln Asn Lys Phe Tyr Ser Gly Thr Gly Phe Lys Phe 
                805                 810                 815     


Leu Pro Phe Ser Phe Glu His Ile Arg Glu Gly Lys Phe Glu Glu 
            820                 825                 830     


<210>  3486
<211>  2798
<212>  DNA
<213>  Homosapiens

<400>  3486
agtagggaag tagctatggc agtgcctgat acaaaataaa ctccaaatgt gtatttatta     60

gatggttgga tggaagttat ttgcgtgtga aagcgcgttt tacccgaagg cgctctgtga    120

gggccagcgg gtccccttcg gccctggagc cggggtcaca cgctccccac cgcgtgcggt    180

cacgagacgc ccccaaggga gtatcctggt acccggaagc cgcgactcct ggccctgagc    240

ccgggcttag ccttcgggtc cacgtggccg gaggccggca gctgattgga cgcgggccgc    300

cccaccccct ggccgtcgcg ggacccgcag gactgagacc atggaggcgg tggcggtggc    360

cgcggcggtg ggggtccttc tcctggccgg ggccgggggc gcggcaggcg acgaggcccg    420

ggaggcggcg gccgtgcggg cgctcgtggc ccggctgctg gggccaggcc ccgcggccga    480

cttctccgtg tcggtggagc gcgctctggc tgccaagccg ggcttggaca cctacagcct    540

gggcggcggc ggcgcggcgc gcgtgcgggt gcgcggctcc acgggcgtgg cggccgccgc    600

ggggctgcac cgctacctgc gcgacttctg tggctgccac gtggcctggt ccggctctca    660

gctgcgcctg ccgcggccac tgccagccgt gccgggggag ctgaccgagg ccacgcccaa    720

caggtaccgc tattaccaga atgtgtgcac gcaaagctac tctttcgtgt ggtgggactg    780

ggcccgctgg gagcgagaga tagactggat ggcgctgaat ggcatcaacc tggcactggc    840

ctggagcggc caggaggcca tctggcagcg ggtgtacctg gccttgggcc tgacccaggc    900

agagatcaat gagttcttta ctggtcctgc cttcctggcc tgggggcgaa tgggcaacct    960

gcacacctgg gatggccccc tgcccccctc ctggcacatc aagcagcttt acctgcagca   1020

ccgggtcctg gaccagatgc gctccttcgg catgacccca gtgctgcctg cattcgcggg   1080

gcatgttccc gaggctgtca ccagggtgtt ccctcaggtc aatgtcacga agatgggcag   1140

ttggggccac tttaactgtt cctactcctg ctccttcctt ctggctccgg aagaccccat   1200

attccccatc atcgggagcc tcttcctgcg agagctgatc aaagagtttg gcacagacca   1260

catctatggg gccgacactt tcaatgagat gcagccacct tcctcagagc cctcctacct   1320

tgccgcagcc accactgccg tctatgaggc catgactgca gtggatactg aggctgtgtg   1380

gctgctccaa ggctggctct tccagcacca gccgcagttc tgggggcccg cccagatcag   1440

ggctgtgctg ggagctgtgc cccgtggccg cctcctggtt ctggacctgt ttgctgagag   1500

ccagcctgtg tatacccgca ctgcctcctt ccagggccag cccttcatct ggtgcatgct   1560

gcacaacttt gggggaaacc atggtctttt tggagcccta gaggctgtga acggaggccc   1620

agaagctgcc cgcctcttcc ccaactccac catggtaggc acgggcatgg cccccgaggg   1680

catcagccag aacgaagtgg tctattccct catggctgag ctgggctggc gaaaggaccc   1740

agtgccagat ttggcagcct gggtgaccag ctttgccgcc cggcggtatg gggtctccca   1800

cccggacgca ggggcagcgt ggaggctact gctccggagt gtgtacaact gctccgggga   1860

ggcctgcagg ggccacaatc gtagcccgct ggtcaggcgg ccgtccctac agatgaatac   1920

cagcatctgg tacaaccgat ctgatgtgtt tgaggcctgg cggctgctgc tcacatctgc   1980

tccctccctg gccaccagcc ccgccttccg ctacgacctg ctggacctca ctcggcaggc   2040

agtgcaggag ctggtcagct tgtactatga ggaggcaaga agcgcctacc tgagcaagga   2100

gctggcctcc ctgttgaggg ctggaggcgt cctggcctat gagctgctgc cggcactgga   2160

cgaggtgctg gctagtgaca gccgcttctt gctgggcagc tggctagagc aggcccgagc   2220

agcggcagtc agtgaggccg aggccgattt ctacgagcag aacagccgct accagctgac   2280

cttgtggggg ccagaaggca acatcctgga ctatgccaac aagcagctgg cggggttggt   2340

ggccaactac tacacccctc gctggcggct tttcctggag gcgctggttg acagtgtggc   2400

ccagggcatc cctttccaac agcaccagtt tgacaaaaat gtcttccaac tggagcaggc   2460

cttcgttctc agcaagcaga ggtaccccag ccagccgcga ggagacactg tggacctggc   2520

caagaagatc ttcctcaaat attacccccg ctgggtggcc ggctcttggt gatagattcg   2580

ccaccactgg gccttgtttt ccgctaattc cagggcagat tccagggccc agagctggac   2640

agacatcaca ggataaccca ggcctgggag gaggccccac ggcctgctgg tggggtctga   2700

cctgggggga ttggagggaa atgacctgcc ctccaccacc acccaaagtg tgggattaaa   2760

gtactgtttt ctttccactt aaaaaaaaaa aaaaaaaa                           2798


<210>  3487
<211>  743
<212>  PRT
<213>  Homosapiens

<400>  3487

Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Gly Asp Glu Ala Arg Glu Ala Ala Ala Val 
            20                  25                  30          


Arg Ala Leu Val Ala Arg Leu Leu Gly Pro Gly Pro Ala Ala Asp Phe 
        35                  40                  45              


Ser Val Ser Val Glu Arg Ala Leu Ala Ala Lys Pro Gly Leu Asp Thr 
    50                  55                  60                  


Tyr Ser Leu Gly Gly Gly Gly Ala Ala Arg Val Arg Val Arg Gly Ser 
65                  70                  75                  80  


Thr Gly Val Ala Ala Ala Ala Gly Leu His Arg Tyr Leu Arg Asp Phe 
                85                  90                  95      


Cys Gly Cys His Val Ala Trp Ser Gly Ser Gln Leu Arg Leu Pro Arg 
            100                 105                 110         


Pro Leu Pro Ala Val Pro Gly Glu Leu Thr Glu Ala Thr Pro Asn Arg 
        115                 120                 125             


Tyr Arg Tyr Tyr Gln Asn Val Cys Thr Gln Ser Tyr Ser Phe Val Trp 
    130                 135                 140                 


Trp Asp Trp Ala Arg Trp Glu Arg Glu Ile Asp Trp Met Ala Leu Asn 
145                 150                 155                 160 


Gly Ile Asn Leu Ala Leu Ala Trp Ser Gly Gln Glu Ala Ile Trp Gln 
                165                 170                 175     


Arg Val Tyr Leu Ala Leu Gly Leu Thr Gln Ala Glu Ile Asn Glu Phe 
            180                 185                 190         


Phe Thr Gly Pro Ala Phe Leu Ala Trp Gly Arg Met Gly Asn Leu His 
        195                 200                 205             


Thr Trp Asp Gly Pro Leu Pro Pro Ser Trp His Ile Lys Gln Leu Tyr 
    210                 215                 220                 


Leu Gln His Arg Val Leu Asp Gln Met Arg Ser Phe Gly Met Thr Pro 
225                 230                 235                 240 


Val Leu Pro Ala Phe Ala Gly His Val Pro Glu Ala Val Thr Arg Val 
                245                 250                 255     


Phe Pro Gln Val Asn Val Thr Lys Met Gly Ser Trp Gly His Phe Asn 
            260                 265                 270         


Cys Ser Tyr Ser Cys Ser Phe Leu Leu Ala Pro Glu Asp Pro Ile Phe 
        275                 280                 285             


Pro Ile Ile Gly Ser Leu Phe Leu Arg Glu Leu Ile Lys Glu Phe Gly 
    290                 295                 300                 


Thr Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met Gln Pro Pro 
305                 310                 315                 320 


Ser Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala Val Tyr Glu 
                325                 330                 335     


Ala Met Thr Ala Val Asp Thr Glu Ala Val Trp Leu Leu Gln Gly Trp 
            340                 345                 350         


Leu Phe Gln His Gln Pro Gln Phe Trp Gly Pro Ala Gln Ile Arg Ala 
        355                 360                 365             


Val Leu Gly Ala Val Pro Arg Gly Arg Leu Leu Val Leu Asp Leu Phe 
    370                 375                 380                 


Ala Glu Ser Gln Pro Val Tyr Thr Arg Thr Ala Ser Phe Gln Gly Gln 
385                 390                 395                 400 


Pro Phe Ile Trp Cys Met Leu His Asn Phe Gly Gly Asn His Gly Leu 
                405                 410                 415     


Phe Gly Ala Leu Glu Ala Val Asn Gly Gly Pro Glu Ala Ala Arg Leu 
            420                 425                 430         


Phe Pro Asn Ser Thr Met Val Gly Thr Gly Met Ala Pro Glu Gly Ile 
        435                 440                 445             


Ser Gln Asn Glu Val Val Tyr Ser Leu Met Ala Glu Leu Gly Trp Arg 
    450                 455                 460                 


Lys Asp Pro Val Pro Asp Leu Ala Ala Trp Val Thr Ser Phe Ala Ala 
465                 470                 475                 480 


Arg Arg Tyr Gly Val Ser His Pro Asp Ala Gly Ala Ala Trp Arg Leu 
                485                 490                 495     


Leu Leu Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys Arg Gly His 
            500                 505                 510         


Asn Arg Ser Pro Leu Val Arg Arg Pro Ser Leu Gln Met Asn Thr Ser 
        515                 520                 525             


Ile Trp Tyr Asn Arg Ser Asp Val Phe Glu Ala Trp Arg Leu Leu Leu 
    530                 535                 540                 


Thr Ser Ala Pro Ser Leu Ala Thr Ser Pro Ala Phe Arg Tyr Asp Leu 
545                 550                 555                 560 


Leu Asp Leu Thr Arg Gln Ala Val Gln Glu Leu Val Ser Leu Tyr Tyr 
                565                 570                 575     


Glu Glu Ala Arg Ser Ala Tyr Leu Ser Lys Glu Leu Ala Ser Leu Leu 
            580                 585                 590         


Arg Ala Gly Gly Val Leu Ala Tyr Glu Leu Leu Pro Ala Leu Asp Glu 
        595                 600                 605             


Val Leu Ala Ser Asp Ser Arg Phe Leu Leu Gly Ser Trp Leu Glu Gln 
    610                 615                 620                 


Ala Arg Ala Ala Ala Val Ser Glu Ala Glu Ala Asp Phe Tyr Glu Gln 
625                 630                 635                 640 


Asn Ser Arg Tyr Gln Leu Thr Leu Trp Gly Pro Glu Gly Asn Ile Leu 
                645                 650                 655     


Asp Tyr Ala Asn Lys Gln Leu Ala Gly Leu Val Ala Asn Tyr Tyr Thr 
            660                 665                 670         


Pro Arg Trp Arg Leu Phe Leu Glu Ala Leu Val Asp Ser Val Ala Gln 
        675                 680                 685             


Gly Ile Pro Phe Gln Gln His Gln Phe Asp Lys Asn Val Phe Gln Leu 
    690                 695                 700                 


Glu Gln Ala Phe Val Leu Ser Lys Gln Arg Tyr Pro Ser Gln Pro Arg 
705                 710                 715                 720 


Gly Asp Thr Val Asp Leu Ala Lys Lys Ile Phe Leu Lys Tyr Tyr Pro 
                725                 730                 735     


Arg Trp Val Ala Gly Ser Trp 
            740             


<210>  3488
<211>  2230
<212>  DNA
<213>  Homosapiens

<400>  3488
gggcctccca aagtgctggg attagaggca tgagccaccg tgcccagcct caaagcatat     60

tttaaaggat agaaataaac agccatatga agagatacag acagggcggt ctggaagggt    120

ccagagcagg agcttctatc tccatagagt tggggttacg tcaccctctg ggcacattct    180

gtcagcctcc acacgttcag ctctcagaag ctcccgaacc ctgtcctttg ggccttttat    240

ggagaactcc attggctgtc catgactgaa gcatggacaa ctgtgataat gtgattgggc    300

aaaaagggtc tgatctaagc ccagcaaggc cagtccagat tctttgggcc tttgtgcagc    360

attcctttct ccagggtatg gggcaaggac ccactctgga atgaggatcc tacaacccac    420

aatcagatta gagtcctgcc ttgggcagct gaaaagagga caggagaagg tcagagagac    480

gaaaggctgt tttttgaggc ctgaggcacc ccaacatgac aacgtaagac tgtaaccatg    540

gtcatgtgag ttatgagcta ggaaccctgg acgaaaccaa cacatataca atcatctccc    600

acctcccaac gcctttactt tcacagcctc tgcagcaaac tgcggtcact ataatcgctc    660

ctgtggcaca gaggcatacc caggggaatc tgcccagggg gccactctgt gcccacgtgg    720

gaacccacac ctgcttgtaa agcctcccct ccctctgacc agcaaccagg acagtttgtt    780

gttccaagca gtgggctcat gtctgttttg gctcagaaca gggtggggag agcgggccag    840

ggacccgcag gaaggcttat ccttgagatt gcgtgggaga cacaacaagg ggtgggggcc    900

cgcaggcggg gcggggcgaa gcaggtgata tcaagcccag agccccagcc tctccccaca    960

gtctcaccat ggcccgcacc gtggtgctca tcaccggctg ttcctcgggc atcggcctgc   1020

acttggccgt acgtctggct tcagatccat cccagagctt caaagtgtat gccacgttga   1080

gggacctgaa aacacagggc cggctgtggg aggcggcccg ggccctggca tgccctccgg   1140

gatccctgga gacgttgcag ctggacgtaa gggactcaaa atccgtggcc gctgcccggg   1200

aacgcgtgac tgagggccgc gtggacgtgc tggtgtgtaa cgcaggcctg ggcctgctgg   1260

ggccgctgga ggcgctgggg gaggacgccg tggcctctgt gctggacgtg aatgtagtag   1320

ggactgtgcg gatgctgcag gccttcctgc cagacatgaa gaggcgcggt tcgggacgcg   1380

tgttggtgac cgggagcgtg ggaggattga tggggctgcc tttcaatgac gtttattgcg   1440

ccagcaagtt cgcgctcgaa ggcttatgcg agagtctggc ggttctgctg ctgccctttg   1500

gggtccactt gagcctgatc gagtgcggcc cagtgcacac cgccttcatg gagaaggtgt   1560

tgggcagccc agaggaggtg ctggaccgca cggacatcca caccttccac cgcttctacc   1620

aatacctcgc ccacagcaag caagtctttc gcgaggcggc gcagaaccct gaggaggtgg   1680

cggaggtctt cctcaccgct ttgcgcgccc cgaagccgac cctgcgctac ttcaccaccg   1740

agcgcttcct gcccctgctg cggatgcgcc tggacgaccc cagcggctcc aactacgtca   1800

ccgccatgca ccgggaagtg ttcggcgacg ttccggcaaa ggccgaggct ggggccgagg   1860

ctgggggcgg ggccgggcct ggggcagagg acgaggccgg gcgcagtgcg gtgggggacc   1920

ctgagctcgg cgatcctccg gccgccccgc agtaaaggct tcctcagccg ctgtctcccg   1980

cgcccttctt tgtcccctgg gtctgtgtgg tccctgggga tggggcggcg gtagcagctg   2040

tgggtggcta attaagatag atcgcgttag ccagttttac cagcgcagct aggcgcgatg   2100

gctgtcgcct gtaatgccag cgctttggga ggcggaggca ggaggatcgc tcaagccccg   2160

gagttggaga ccagccagag caacacagtg agacccccat ctctacaaaa ataaagaaaa   2220

tttaaaaatc                                                          2230


<210>  3489
<211>  328
<212>  PRT
<213>  Homosapiens

<400>  3489

Met Ala Arg Thr Val Val Leu Ile Thr Gly Cys Ser Ser Gly Ile Gly 
1               5                   10                  15      


Leu His Leu Ala Val Arg Leu Ala Ser Asp Pro Ser Gln Ser Phe Lys 
            20                  25                  30          


Val Tyr Ala Thr Leu Arg Asp Leu Lys Thr Gln Gly Arg Leu Trp Glu 
        35                  40                  45              


Ala Ala Arg Ala Leu Ala Cys Pro Pro Gly Ser Leu Glu Thr Leu Gln 
    50                  55                  60                  


Leu Asp Val Arg Asp Ser Lys Ser Val Ala Ala Ala Arg Glu Arg Val 
65                  70                  75                  80  


Thr Glu Gly Arg Val Asp Val Leu Val Cys Asn Ala Gly Leu Gly Leu 
                85                  90                  95      


Leu Gly Pro Leu Glu Ala Leu Gly Glu Asp Ala Val Ala Ser Val Leu 
            100                 105                 110         


Asp Val Asn Val Val Gly Thr Val Arg Met Leu Gln Ala Phe Leu Pro 
        115                 120                 125             


Asp Met Lys Arg Arg Gly Ser Gly Arg Val Leu Val Thr Gly Ser Val 
    130                 135                 140                 


Gly Gly Leu Met Gly Leu Pro Phe Asn Asp Val Tyr Cys Ala Ser Lys 
145                 150                 155                 160 


Phe Ala Leu Glu Gly Leu Cys Glu Ser Leu Ala Val Leu Leu Leu Pro 
                165                 170                 175     


Phe Gly Val His Leu Ser Leu Ile Glu Cys Gly Pro Val His Thr Ala 
            180                 185                 190         


Phe Met Glu Lys Val Leu Gly Ser Pro Glu Glu Val Leu Asp Arg Thr 
        195                 200                 205             


Asp Ile His Thr Phe His Arg Phe Tyr Gln Tyr Leu Ala His Ser Lys 
    210                 215                 220                 


Gln Val Phe Arg Glu Ala Ala Gln Asn Pro Glu Glu Val Ala Glu Val 
225                 230                 235                 240 


Phe Leu Thr Ala Leu Arg Ala Pro Lys Pro Thr Leu Arg Tyr Phe Thr 
                245                 250                 255     


Thr Glu Arg Phe Leu Pro Leu Leu Arg Met Arg Leu Asp Asp Pro Ser 
            260                 265                 270         


Gly Ser Asn Tyr Val Thr Ala Met His Arg Glu Val Phe Gly Asp Val 
        275                 280                 285             


Pro Ala Lys Ala Glu Ala Gly Ala Glu Ala Gly Gly Gly Ala Gly Pro 
    290                 295                 300                 


Gly Ala Glu Asp Glu Ala Gly Arg Ser Ala Val Gly Asp Pro Glu Leu 
305                 310                 315                 320 


Gly Asp Pro Pro Ala Ala Pro Gln 
                325             


<210>  3490
<211>  2568
<212>  DNA
<213>  Homosapiens

<400>  3490
cgccacccgc ttcctcgccg cagggggccc gcccgctggc ccgtttccgg tccggtgggt     60

acaagatgac ggagccgggc gcctctcccg aggacccttg ggtcaaggca agccccgtgg    120

gcgcgcacgc cggcgagggg agggcgggtc gggctcgtgc acgtaggggg gccggaagac    180

gaggggcttc cctcctgtcc ccaaagtccc ccacgctctc cgtgccccgg ggctgcagag    240

aagacagctc tcaccccgcg tgtgccaagg tggagtatgc ctacagcgac aacagcctgg    300

accccgggct ttttgtagaa agcacccgca aggggagtgt agtgtccaga gctaatagca    360

tcggttccac cagtgcctct tctgtcccca acacagatga tgaggacagt gattaccacc    420

aggaggccta caaggagtcc tacaaagacc ggcggcggcg cgcacacact caggctgagc    480

agaagaggag ggacgccatc aagagaggct atgatgacct tcagaccatc gtccccactt    540

gccagcagca ggacttctcc attggctccc aaaagctcag caaagccatc gttctacaaa    600

agaccattga ctacattcag tttttgcaca aggagaagaa aaagcaggag gaggaggtgt    660

ccacgttacg caaggatgtc accgccctaa agatcatgaa agtgaactat gagcagattg    720

tgaaggcaca ccaggacaac ccccatgaag gggaggacca ggtctctgac caggtcaagt    780

tcaacgtgtt tcaaggcatc atggattccc tgttccagtc cttcaatgcc tccatctcag    840

tggccagctt ccaggagctg tcagcgtgtg tcttcagctg gatcgaggag cactgtaagc    900

ctcagaccct gcgggagatt gtgattggcg tcctgcacca attgaaaaac cagctttact    960

gaccggttct tggaaacctg gagaacagcc aacaagaggc ccttgaatct ctacgtggcc   1020

actgaactgc tgggcccggg agactggact acaacacctc acactggtca gctggtttct   1080

acttggtgtt tggtttttcc cagccccatt ttatcttcag cggagccgcg gtgtttgttt   1140

tgtgaaagct tctgattaat ttattatatt gacgataaaa ctcaaaccta cccagccttc   1200

cccccactcc atggaagtcc ttgggatggg cgtctgctct ggacacccca aagagctcct   1260

gccctctcag ccctttattc aagcctcaga tttctgctca tgatctacat agatttggaa   1320

actgttttcc tctgttttgg tctcttgggc aacatttttg gcccaagttt gggcaacatt   1380

tggcccaagt ttgggcattt tggcagtagc tgtatgggag aaaaagagta agaggaaata   1440

ttcccacagc catgaagggt gaaagggcac cttgtgccta gactagggct gcctggtcag   1500

tcccaggtga ggccaagggc tttctggcca tctcagggag gggccaccag gttcctcccc   1560

tcaccccata ttccatcacc ttcctcctct gctctgggtg gtaagggaag ccctcccggt   1620

tcccacaggc tatgatgctg catggcagag gcaggtataa cacagcacta catattggaa   1680

attttttatt tttctaaata ccaatgcagt tttgctacgg ttacaatttt gaaatattaa   1740

ctgagcctca aaatcaccct ttctgtcaag catatcttgg cctctcccat gtctcagtgt   1800

tgcctgcatt tctcccagga cttgggggtg gggtgaaaag cgtacaaaag atacttaaaa   1860

gggctcctgg ggtacacaag cccagcaggt cctgagtgaa gccgtgggcc ctccaaatgc   1920

tcgttttata gcaacctctc tctaccctag ttctccaaat tcacttctgc cttcctcagg   1980

tttgatatct ggcaggtttg actatccaga ggaaattaaa tatttttata taaaattaaa   2040

ttataataaa tattgccaaa tgctttcctt tagcattgtt ccaagtctaa atgttaacct   2100

caagctactg caatttagac aatgaaatgg gctgggtcta cccccagcca ccagccctca   2160

tcctctctac ccagtgctct ggtttatgct tgtctcctga ctgctctgct taaaggtgaa   2220

agtagcagga acaacaacaa aagccaacca aaaacaaggt agccagtgca agacatctca   2280

ctcttctgac atcctgcagt ccccaccagt cctgaccgtg ggcccctcag gggtctggga   2340

gtgtgacgtt gtaatcttca tccgtctcta tcccaacttc ctcctgtgag acagggagac   2400

aagtgaatga gatgtcacca ggataagacc acagggaagc aaagaaggaa gagagctcca   2460

cttacaaaga actgcttctt gctcttgggg tatccttcaa gtattgcatc agacagctct   2520

gtagcctgac aagaaataaa accacccgtt ttcagatggg caaaaaaa                2568


<210>  3491
<211>  298
<212>  PRT
<213>  Homosapiens

<400>  3491

Met Thr Glu Pro Gly Ala Ser Pro Glu Asp Pro Trp Val Lys Ala Ser 
1               5                   10                  15      


Pro Val Gly Ala His Ala Gly Glu Gly Arg Ala Gly Arg Ala Arg Ala 
            20                  25                  30          


Arg Arg Gly Ala Gly Arg Arg Gly Ala Ser Leu Leu Ser Pro Lys Ser 
        35                  40                  45              


Pro Thr Leu Ser Val Pro Arg Gly Cys Arg Glu Asp Ser Ser His Pro 
    50                  55                  60                  


Ala Cys Ala Lys Val Glu Tyr Ala Tyr Ser Asp Asn Ser Leu Asp Pro 
65                  70                  75                  80  


Gly Leu Phe Val Glu Ser Thr Arg Lys Gly Ser Val Val Ser Arg Ala 
                85                  90                  95      


Asn Ser Ile Gly Ser Thr Ser Ala Ser Ser Val Pro Asn Thr Asp Asp 
            100                 105                 110         


Glu Asp Ser Asp Tyr His Gln Glu Ala Tyr Lys Glu Ser Tyr Lys Asp 
        115                 120                 125             


Arg Arg Arg Arg Ala His Thr Gln Ala Glu Gln Lys Arg Arg Asp Ala 
    130                 135                 140                 


Ile Lys Arg Gly Tyr Asp Asp Leu Gln Thr Ile Val Pro Thr Cys Gln 
145                 150                 155                 160 


Gln Gln Asp Phe Ser Ile Gly Ser Gln Lys Leu Ser Lys Ala Ile Val 
                165                 170                 175     


Leu Gln Lys Thr Ile Asp Tyr Ile Gln Phe Leu His Lys Glu Lys Lys 
            180                 185                 190         


Lys Gln Glu Glu Glu Val Ser Thr Leu Arg Lys Asp Val Thr Ala Leu 
        195                 200                 205             


Lys Ile Met Lys Val Asn Tyr Glu Gln Ile Val Lys Ala His Gln Asp 
    210                 215                 220                 


Asn Pro His Glu Gly Glu Asp Gln Val Ser Asp Gln Val Lys Phe Asn 
225                 230                 235                 240 


Val Phe Gln Gly Ile Met Asp Ser Leu Phe Gln Ser Phe Asn Ala Ser 
                245                 250                 255     


Ile Ser Val Ala Ser Phe Gln Glu Leu Ser Ala Cys Val Phe Ser Trp 
            260                 265                 270         


Ile Glu Glu His Cys Lys Pro Gln Thr Leu Arg Glu Ile Val Ile Gly 
        275                 280                 285             


Val Leu His Gln Leu Lys Asn Gln Leu Tyr 
    290                 295             


<210>  3492
<211>  2406
<212>  DNA
<213>  Homosapiens

<400>  3492
cgccacccgc ttcctcgccg cagggggccc gcccgctggc ccgtttccgg tccggtgggt     60

acaagatgac ggagccgggc gcctctcccg aggacccttg ggtcaaggtg gagtatgcct    120

acagcgacaa cagcctggac cccgggcttt ttgtagaaag cacccgcaag gggagtgtag    180

tgtccagagc taatagcatc ggttccacca gtgcctcttc tgtccccaac acagatgatg    240

aggacagtga ttaccaccag gaggcctaca aggagtccta caaagaccgg cggcggcgcg    300

cacacactca ggctgagcag aagaggaggg acgccatcaa gagaggctat gatgaccttc    360

agaccatcgt ccccacttgc cagcagcagg acttctccat tggctcccaa aagctcagca    420

aagccatcgt tctacaaaag accattgact acattcagtt tttgcacaag gagaagaaaa    480

agcaggagga ggaggtgtcc acgttacgca aggatgtcac cgccctaaag atcatgaaag    540

tgaactatga gcagattgtg aaggcacacc aggacaaccc ccatgaaggg gaggaccagg    600

tctctgacca ggtcaagttc aacgtgtttc aaggcatcat ggattccctg ttccagtcct    660

tcaatgcctc catctcagtg gccagcttcc aggagctgtc agcgtgtgtc ttcagctgga    720

tcgaggagca ctgtaagcct cagaccctgc gggagattgt gattggcgtc ctgcaccaat    780

tgaaaaacca gctttactga ccggttcttg gaaacctgga gaacagccaa caagaggccc    840

ttgaatctct acgtggccac tgaactgctg ggcccgggag actggactac aacacctcac    900

actggtcagc tggtttctac ttggtgtttg gtttttccca gccccatttt atcttcagcg    960

gagccgcggt gtttgttttg tgaaagcttc tgattaattt attatattga cgataaaact   1020

caaacctacc cagccttccc cccactccat ggaagtcctt gggatgggcg tctgctctgg   1080

acaccccaaa gagctcctgc cctctcagcc ctttattcaa gcctcagatt tctgctcatg   1140

atctacatag atttggaaac tgttttcctc tgttttggtc tcttgggcaa catttttggc   1200

ccaagtttgg gcaacatttg gcccaagttt gggcattttg gcagtagctg tatgggagaa   1260

aaagagtaag aggaaatatt cccacagcca tgaagggtga aagggcacct tgtgcctaga   1320

ctagggctgc ctggtcagtc ccaggtgagg ccaagggctt tctggccatc tcagggaggg   1380

gccaccaggt tcctcccctc accccatatt ccatcacctt cctcctctgc tctgggtggt   1440

aagggaagcc ctcccggttc ccacaggcta tgatgctgca tggcagaggc aggtataaca   1500

cagcactaca tattggaaat tttttatttt tctaaatacc aatgcagttt tgctacggtt   1560

acaattttga aatattaact gagcctcaaa atcacccttt ctgtcaagca tatcttggcc   1620

tctcccatgt ctcagtgttg cctgcatttc tcccaggact tgggggtggg gtgaaaagcg   1680

tacaaaagat acttaaaagg gctcctgggg tacacaagcc cagcaggtcc tgagtgaagc   1740

cgtgggccct ccaaatgctc gttttatagc aacctctctc taccctagtt ctccaaattc   1800

acttctgcct tcctcaggtt tgatatctgg caggtttgac tatccagagg aaattaaata   1860

tttttatata aaattaaatt ataataaata ttgccaaatg ctttccttta gcattgttcc   1920

aagtctaaat gttaacctca agctactgca atttagacaa tgaaatgggc tgggtctacc   1980

cccagccacc agccctcatc ctctctaccc agtgctctgg tttatgcttg tctcctgact   2040

gctctgctta aaggtgaaag tagcaggaac aacaacaaaa gccaaccaaa aacaaggtag   2100

ccagtgcaag acatctcact cttctgacat cctgcagtcc ccaccagtcc tgaccgtggg   2160

cccctcaggg gtctgggagt gtgacgttgt aatcttcatc cgtctctatc ccaacttcct   2220

cctgtgagac agggagacaa gtgaatgaga tgtcaccagg ataagaccac agggaagcaa   2280

agaaggaaga gagctccact tacaaagaac tgcttcttgc tcttggggta tccttcaagt   2340

attgcatcag acagctctgt agcctgacaa gaaataaaac cacccgtttt cagatgggca   2400

aaaaaa                                                              2406


<210>  3493
<211>  244
<212>  PRT
<213>  Homosapiens

<400>  3493

Met Thr Glu Pro Gly Ala Ser Pro Glu Asp Pro Trp Val Lys Val Glu 
1               5                   10                  15      


Tyr Ala Tyr Ser Asp Asn Ser Leu Asp Pro Gly Leu Phe Val Glu Ser 
            20                  25                  30          


Thr Arg Lys Gly Ser Val Val Ser Arg Ala Asn Ser Ile Gly Ser Thr 
        35                  40                  45              


Ser Ala Ser Ser Val Pro Asn Thr Asp Asp Glu Asp Ser Asp Tyr His 
    50                  55                  60                  


Gln Glu Ala Tyr Lys Glu Ser Tyr Lys Asp Arg Arg Arg Arg Ala His 
65                  70                  75                  80  


Thr Gln Ala Glu Gln Lys Arg Arg Asp Ala Ile Lys Arg Gly Tyr Asp 
                85                  90                  95      


Asp Leu Gln Thr Ile Val Pro Thr Cys Gln Gln Gln Asp Phe Ser Ile 
            100                 105                 110         


Gly Ser Gln Lys Leu Ser Lys Ala Ile Val Leu Gln Lys Thr Ile Asp 
        115                 120                 125             


Tyr Ile Gln Phe Leu His Lys Glu Lys Lys Lys Gln Glu Glu Glu Val 
    130                 135                 140                 


Ser Thr Leu Arg Lys Asp Val Thr Ala Leu Lys Ile Met Lys Val Asn 
145                 150                 155                 160 


Tyr Glu Gln Ile Val Lys Ala His Gln Asp Asn Pro His Glu Gly Glu 
                165                 170                 175     


Asp Gln Val Ser Asp Gln Val Lys Phe Asn Val Phe Gln Gly Ile Met 
            180                 185                 190         


Asp Ser Leu Phe Gln Ser Phe Asn Ala Ser Ile Ser Val Ala Ser Phe 
        195                 200                 205             


Gln Glu Leu Ser Ala Cys Val Phe Ser Trp Ile Glu Glu His Cys Lys 
    210                 215                 220                 


Pro Gln Thr Leu Arg Glu Ile Val Ile Gly Val Leu His Gln Leu Lys 
225                 230                 235                 240 


Asn Gln Leu Tyr 
                


<210>  3494
<211>  2316
<212>  DNA
<213>  Homosapiens

<400>  3494
cgccacccgc ttcctcgccg cagggggccc gcccgctggc ccgtttccgg tccggtgggt     60

acaagatgac ggagccgggc gcctctcccg aggacccttg ggtcaaggtg gagtatgcct    120

acagcgacaa cagcctggac cccgatgatg aggacagtga ttaccaccag gaggcctaca    180

aggagtccta caaagaccgg cggcggcgcg cacacactca ggctgagcag aagaggaggg    240

acgccatcaa gagaggctat gatgaccttc agaccatcgt ccccacttgc cagcagcagg    300

acttctccat tggctcccaa aagctcagca aagccatcgt tctacaaaag accattgact    360

acattcagtt tttgcacaag gagaagaaaa agcaggagga ggaggtgtcc acgttacgca    420

aggatgtcac cgccctaaag atcatgaaag tgaactatga gcagattgtg aaggcacacc    480

aggacaaccc ccatgaaggg gaggaccagg tctctgacca ggtcaagttc aacgtgtttc    540

aaggcatcat ggattccctg ttccagtcct tcaatgcctc catctcagtg gccagcttcc    600

aggagctgtc agcgtgtgtc ttcagctgga tcgaggagca ctgtaagcct cagaccctgc    660

gggagattgt gattggcgtc ctgcaccaat tgaaaaacca gctttactga ccggttcttg    720

gaaacctgga gaacagccaa caagaggccc ttgaatctct acgtggccac tgaactgctg    780

ggcccgggag actggactac aacacctcac actggtcagc tggtttctac ttggtgtttg    840

gtttttccca gccccatttt atcttcagcg gagccgcggt gtttgttttg tgaaagcttc    900

tgattaattt attatattga cgataaaact caaacctacc cagccttccc cccactccat    960

ggaagtcctt gggatgggcg tctgctctgg acaccccaaa gagctcctgc cctctcagcc   1020

ctttattcaa gcctcagatt tctgctcatg atctacatag atttggaaac tgttttcctc   1080

tgttttggtc tcttgggcaa catttttggc ccaagtttgg gcaacatttg gcccaagttt   1140

gggcattttg gcagtagctg tatgggagaa aaagagtaag aggaaatatt cccacagcca   1200

tgaagggtga aagggcacct tgtgcctaga ctagggctgc ctggtcagtc ccaggtgagg   1260

ccaagggctt tctggccatc tcagggaggg gccaccaggt tcctcccctc accccatatt   1320

ccatcacctt cctcctctgc tctgggtggt aagggaagcc ctcccggttc ccacaggcta   1380

tgatgctgca tggcagaggc aggtataaca cagcactaca tattggaaat tttttatttt   1440

tctaaatacc aatgcagttt tgctacggtt acaattttga aatattaact gagcctcaaa   1500

atcacccttt ctgtcaagca tatcttggcc tctcccatgt ctcagtgttg cctgcatttc   1560

tcccaggact tgggggtggg gtgaaaagcg tacaaaagat acttaaaagg gctcctgggg   1620

tacacaagcc cagcaggtcc tgagtgaagc cgtgggccct ccaaatgctc gttttatagc   1680

aacctctctc taccctagtt ctccaaattc acttctgcct tcctcaggtt tgatatctgg   1740

caggtttgac tatccagagg aaattaaata tttttatata aaattaaatt ataataaata   1800

ttgccaaatg ctttccttta gcattgttcc aagtctaaat gttaacctca agctactgca   1860

atttagacaa tgaaatgggc tgggtctacc cccagccacc agccctcatc ctctctaccc   1920

agtgctctgg tttatgcttg tctcctgact gctctgctta aaggtgaaag tagcaggaac   1980

aacaacaaaa gccaaccaaa aacaaggtag ccagtgcaag acatctcact cttctgacat   2040

cctgcagtcc ccaccagtcc tgaccgtggg cccctcaggg gtctgggagt gtgacgttgt   2100

aatcttcatc cgtctctatc ccaacttcct cctgtgagac agggagacaa gtgaatgaga   2160

tgtcaccagg ataagaccac agggaagcaa agaaggaaga gagctccact tacaaagaac   2220

tgcttcttgc tcttggggta tccttcaagt attgcatcag acagctctgt agcctgacaa   2280

gaaataaaac cacccgtttt cagatgggca aaaaaa                             2316


<210>  3495
<211>  214
<212>  PRT
<213>  Homosapiens

<400>  3495

Met Thr Glu Pro Gly Ala Ser Pro Glu Asp Pro Trp Val Lys Val Glu 
1               5                   10                  15      


Tyr Ala Tyr Ser Asp Asn Ser Leu Asp Pro Asp Asp Glu Asp Ser Asp 
            20                  25                  30          


Tyr His Gln Glu Ala Tyr Lys Glu Ser Tyr Lys Asp Arg Arg Arg Arg 
        35                  40                  45              


Ala His Thr Gln Ala Glu Gln Lys Arg Arg Asp Ala Ile Lys Arg Gly 
    50                  55                  60                  


Tyr Asp Asp Leu Gln Thr Ile Val Pro Thr Cys Gln Gln Gln Asp Phe 
65                  70                  75                  80  


Ser Ile Gly Ser Gln Lys Leu Ser Lys Ala Ile Val Leu Gln Lys Thr 
                85                  90                  95      


Ile Asp Tyr Ile Gln Phe Leu His Lys Glu Lys Lys Lys Gln Glu Glu 
            100                 105                 110         


Glu Val Ser Thr Leu Arg Lys Asp Val Thr Ala Leu Lys Ile Met Lys 
        115                 120                 125             


Val Asn Tyr Glu Gln Ile Val Lys Ala His Gln Asp Asn Pro His Glu 
    130                 135                 140                 


Gly Glu Asp Gln Val Ser Asp Gln Val Lys Phe Asn Val Phe Gln Gly 
145                 150                 155                 160 


Ile Met Asp Ser Leu Phe Gln Ser Phe Asn Ala Ser Ile Ser Val Ala 
                165                 170                 175     


Ser Phe Gln Glu Leu Ser Ala Cys Val Phe Ser Trp Ile Glu Glu His 
            180                 185                 190         


Cys Lys Pro Gln Thr Leu Arg Glu Ile Val Ile Gly Val Leu His Gln 
        195                 200                 205             


Leu Lys Asn Gln Leu Tyr 
    210                 


<210>  3496
<211>  1418
<212>  DNA
<213>  Homosapiens

<400>  3496
cacgagggga gtccgggagg ggtcgctttg ctcctccgga aggcttcccc ttcagccaat     60

caccgttcga ggcccgcccc cgtcgccgga aggagccgtc gccccgagca actacaacgt    120

ccggctttct gagttgggtg gcgggaaagg cgatgagtaa aggccgggca gaagctgcgg    180

cgggagccgc cgggatcctc ctgaggtacc tgcaggagca gaaccggccc tacagctccc    240

aggatgtgtt cgggaaccta cagcgggaac acggactggg caaggcggtg gtggtgaaga    300

cgctggagca gctggcgcaa caaggcaaga tcaaagagaa gatgtacggc aagcagaaga    360

tctattttgc ggatcaggac cagtttgaca tggtgagtga tgctgacctt caagtcctag    420

atggcaaaat cgtggccctc actgctaagg tgcagagctt gcagcagagc tgccgctaca    480

tggaggctga gatgcagaaa gaaatccagg agttaaagaa ggaatgcgct ggctacagag    540

agagattgaa gaacattaaa gcagctacca atcatgtgac tccagaagag aaagagcagg    600

tgtacagaga gaggcagaag tactgtaagg agtggaggaa gaggaagagg atggctacag    660

agctgtctga tgcaatactt gaaggatacc ccaagagcaa gaagcagttc tttgaggaag    720

ttgggataga gacggatgaa gattacaacg tcacactccc agacccctga ggggcccacg    780

gtcaggactg gtggggactg caggatgtca gaagagtgag atgtcttgca ctggctacct    840

tgtttttggt tggcttttgt tgttgttcct gctactttca cctttaagca gagcagtcag    900

gagacaagca taaaccagag cactgggtag agaggatgag ggctggtggc tgggggtaga    960

cccagcccat ttcattgtct aaattgcagt agcttgaggt taacatttag acttggaaca   1020

atgctaaagg aaagcatttg gcaatattta ttataattta attttatata aaaatattta   1080

atttcctctg gatagtcaaa cctgccagat atcaaacctg aggaaggcag aagtgaattt   1140

ggagaactag ggtagagaga ggttgctata aaacgagcat ttggagggcc cacggcttca   1200

ctcaggacct gctgggcttg tgtaccccag gagccctttt aagtatcttt tgtacgcttt   1260

tcaccccacc cccaagtcct gggagaaatg caggcaacac tgagacatgg gagaggccaa   1320

gatatgcttg acagaaaggg tgattttgag gctcagttaa tatttcaaaa ttgtaaccgt   1380

agcaaaactg cattggtatt tagaaaaaaa aaaaaaaa                           1418


<210>  3497
<211>  205
<212>  PRT
<213>  Homosapiens

<400>  3497

Met Ser Lys Gly Arg Ala Glu Ala Ala Ala Gly Ala Ala Gly Ile Leu 
1               5                   10                  15      


Leu Arg Tyr Leu Gln Glu Gln Asn Arg Pro Tyr Ser Ser Gln Asp Val 
            20                  25                  30          


Phe Gly Asn Leu Gln Arg Glu His Gly Leu Gly Lys Ala Val Val Val 
        35                  40                  45              


Lys Thr Leu Glu Gln Leu Ala Gln Gln Gly Lys Ile Lys Glu Lys Met 
    50                  55                  60                  


Tyr Gly Lys Gln Lys Ile Tyr Phe Ala Asp Gln Asp Gln Phe Asp Met 
65                  70                  75                  80  


Val Ser Asp Ala Asp Leu Gln Val Leu Asp Gly Lys Ile Val Ala Leu 
                85                  90                  95      


Thr Ala Lys Val Gln Ser Leu Gln Gln Ser Cys Arg Tyr Met Glu Ala 
            100                 105                 110         


Glu Met Gln Lys Glu Ile Gln Glu Leu Lys Lys Glu Cys Ala Gly Tyr 
        115                 120                 125             


Arg Glu Arg Leu Lys Asn Ile Lys Ala Ala Thr Asn His Val Thr Pro 
    130                 135                 140                 


Glu Glu Lys Glu Gln Val Tyr Arg Glu Arg Gln Lys Tyr Cys Lys Glu 
145                 150                 155                 160 


Trp Arg Lys Arg Lys Arg Met Ala Thr Glu Leu Ser Asp Ala Ile Leu 
                165                 170                 175     


Glu Gly Tyr Pro Lys Ser Lys Lys Gln Phe Phe Glu Glu Val Gly Ile 
            180                 185                 190         


Glu Thr Asp Glu Asp Tyr Asn Val Thr Leu Pro Asp Pro 
        195                 200                 205 


<210>  3498
<211>  1349
<212>  DNA
<213>  Homosapiens

<400>  3498
aactacaacg tccggctttc tgagttgggt ggcgggaaag gcgatgagta aaggccgggc     60

agaagctgcg gcgggagccg ccgggatcct cctgaggtac ctgcaggaac agaaccggcc    120

ctacagctcc caggatgtgt tcgggaacct acagcgggaa cacggactgg gcaaggcggt    180

ggtggtgaag acgctggagc agctggcgca acaaggcaag atcaaagaga agatgtacgg    240

caagcagaag atctattttg cggatcagga ccagtttgac atggtgagtg atgctgacct    300

tcaagtccta gatggcaaaa tcgtggccct cactgctaag gtgcagagct tgcagcagag    360

ctgccgctac atggaggctg agctcaagga attatctagt gccctgacca caccagagat    420

gcagaaagaa atccaggagt taaagaagga atgcgctggc tacagagaga gattgaagaa    480

cattaaagca gctaccaatc atgtgactcc agaagagaaa gagcaggtgt acagagagag    540

gcagaagtac tgtaaggagt ggaggaagag gaagaggatg gctacagagc tgtctgatgc    600

aatacttgaa ggatacccca agagcaagaa gcagttcttt gaggaagttg ggatagagac    660

ggatgaagat tacaacgtca cactcccaga cccctgaggg gcccacggtc aggactggtg    720

gggactgcag gatgtcagaa gagtgagatg tcttgcactg gctaccttgt ttttggttgg    780

cttttgttgt tgttcctctt acttttcact ttagcagagc agtcaggaga caagcataaa    840

ccagagcact gggtagagag gatgagggct ggtggctggg ggtagacccc acgcatttca    900

ttgtctaaat tgcagtagct tgaggttaac atttagactt ggaacaatgc taaaggaaag    960

catttggcaa tatttattat aatttaattt tatataaaaa tatttaattt cctctggata   1020

gtcaaacctg ccagatatca aacctgagga aggcagaagt gaatttggag aactagggta   1080

gagagaggtt gctataaaac gagcatttgg agggcccacg gcttcactca ggacctgctg   1140

ggcttgtgta ccccaggagc ccttttaagt atcttttgta cgcttttcac cccaccccca   1200

agtcctggga gaaatgcagg caacactgag acatgggaga ggccaagata tgcttgacag   1260

aaagggtgat tttgaggctc agttaatatt tcaaaattgt aaccgtagca aaactgcatt   1320

ggtatttaga aaaataaaaa atttccaat                                     1349


<210>  3499
<211>  217
<212>  PRT
<213>  Homosapiens

<400>  3499

Met Ser Lys Gly Arg Ala Glu Ala Ala Ala Gly Ala Ala Gly Ile Leu 
1               5                   10                  15      


Leu Arg Tyr Leu Gln Glu Gln Asn Arg Pro Tyr Ser Ser Gln Asp Val 
            20                  25                  30          


Phe Gly Asn Leu Gln Arg Glu His Gly Leu Gly Lys Ala Val Val Val 
        35                  40                  45              


Lys Thr Leu Glu Gln Leu Ala Gln Gln Gly Lys Ile Lys Glu Lys Met 
    50                  55                  60                  


Tyr Gly Lys Gln Lys Ile Tyr Phe Ala Asp Gln Asp Gln Phe Asp Met 
65                  70                  75                  80  


Val Ser Asp Ala Asp Leu Gln Val Leu Asp Gly Lys Ile Val Ala Leu 
                85                  90                  95      


Thr Ala Lys Val Gln Ser Leu Gln Gln Ser Cys Arg Tyr Met Glu Ala 
            100                 105                 110         


Glu Leu Lys Glu Leu Ser Ser Ala Leu Thr Thr Pro Glu Met Gln Lys 
        115                 120                 125             


Glu Ile Gln Glu Leu Lys Lys Glu Cys Ala Gly Tyr Arg Glu Arg Leu 
    130                 135                 140                 


Lys Asn Ile Lys Ala Ala Thr Asn His Val Thr Pro Glu Glu Lys Glu 
145                 150                 155                 160 


Gln Val Tyr Arg Glu Arg Gln Lys Tyr Cys Lys Glu Trp Arg Lys Arg 
                165                 170                 175     


Lys Arg Met Ala Thr Glu Leu Ser Asp Ala Ile Leu Glu Gly Tyr Pro 
            180                 185                 190         


Lys Ser Lys Lys Gln Phe Phe Glu Glu Val Gly Ile Glu Thr Asp Glu 
        195                 200                 205             


Asp Tyr Asn Val Thr Leu Pro Asp Pro 
    210                 215         


<210>  3500
<211>  3779
<212>  DNA
<213>  Homosapiens

<400>  3500
agttgctgtt attgtgactt gtcgggccac ggccccggat gttgtggctg ccgcggggag     60

atggctgagg ccgaaggggt tcccacgacc ccaggcccgg cttcggggtc gactttcagg    120

ggccgccgag atgtgtcagg ctcctgggag cgggaccagc aggttgaggc ggcgcagcgg    180

gccctggtgg aggtgctggg gccttacgag cctctgctga gtcgggtgca ggcagccctg    240

gtgtgggagc ggccagctag gagcgctctg tggtgcctgg ggctgaacgc ggctttctgg    300

ttttttgccc tgacatctct tcgtcttgtg tttttacttg catttggctt gatgatcatt    360

gtgtgtattg atcaatggaa gaacaaaatc tggcctgaaa taaaagtgcc aagacccgac    420

gcattagaca atgagagctg gggctttgtg caccctcggt tgctcagcgt gcccgagctc    480

tgccaccatg tagctgaagt ctgggttagt gggaccattt tcataaggaa tgttttgctt    540

ttcaaaaagc aaaacccagg caagttctgc ttgctgagct gtgggatact gacctttttg    600

gctgtcttgg gccgctacgt ccctgggctt ctgctgtcct acttgatgct tgtcactgtc    660

atgatgtggc cccttgctgt gtaccaccga ctgtgggatc gagcatatgt gcggctgaag    720

ccagctctgc agcggctaga cttcagtgtc cgtggctaca tgatgtccaa gcagagagag    780

agacaattac gccgcagagc tctccaccca gaacgagcca tggacaacca cagtgacagc    840

gaagaggagc ttgctgcctt ctgtcctcag ctggacgatt ctactgttgc cagggaattg    900

gccatcacag actctgagca ctcagacgct gaagtctcct gtacagacaa tggcacattc    960

aatctttcaa ggggccaaac acctctaacg gaaggctctg aagacctaga tggtcacagt   1020

gatccagagg aatcctttgc cagagacctt ccagacttcc cttccattaa tatggatcct   1080

gctggcctgg atgatgagga cgacactagc attggcatgc ccagcttgat gtaccgttct   1140

ccgccagggg ctgaggagcc ccaggcccca cctgccagcc gggacgaggc tgcgctgccg   1200

gagctcctgc ttggtgctct tcctgtagga tccaacctca ccagcaacct tgccagcctg   1260

gtctcccagg gtatgattca gctggccttg tcaggggcct cccaaccagg cccttctgga   1320

gcacctgccc agagagcaac gagaggcttc ctccggtccc ccagttcaga cctggacact   1380

gatgctgagg gggatgactt tgaacttctg gaccagtcgg agctgagtca gctggaccct   1440

gccagttcta ggagccactg aggcagagac tcctttttgg agtcactgtg gtttaggttt   1500

ttttctcccc atcccactta aggtgatggg gcaagggaag aactcagctc ccctcccctg   1560

aattatattt gtatgctggg tggcctggct gatgctcaga ggcctcctta gagaggacac   1620

tcactcccct cccaccagct ggatgcccat ttctgagctc agtcactgaa gtgagagtgt   1680

gctcccccaa gggaggcttc tctccatcag gatggtactt tgggggaaca aaatagtcag   1740

ggatattggt tcccctttga ggaggtgctg ctgtttgctt ttaggtatga gtgctcaggg   1800

gccctcactg aaagagccca tgcctgcctt cctcctttca tcgcctctct agagccccca   1860

aagtcaggca gcagctggag tagttacatt gtcatcatct ttttttttga gacagtttcg   1920

ctctgttgcc caggctggag tgcagtggtg tgatcttggc tttctgcaac gtctgccttc   1980

caggttgaag aggttctcct gcctcagcct ccttagtagt gggattacag gtgcccgcta   2040

ctatgcccgg ctaatttttc ttttggtatt tttagtagaa atggggtttc accatgttgg   2100

ccaggctggt ctcaaactcc tgacctcaag tgagctgact gccttggcct cccagagtgc   2160

tgggattagt cgtcatcttt tgttaaacca ggatttgatt tttttctttt cttttctttt   2220

cttttctttt tttttttttt tgagacagag tctctctctg ttgcccaggc tggagtgcag   2280

tggcacaatc tcggctcact gcagcctccg cctgccgggt caagcgattc tcctacctca   2340

gcctcctcag tagctgagat tacaggcatg caccaccatg cccggctaat ttttttgtgt   2400

ttttagtaga gatggggttt caccgtgctg gccaggctgg tctagaactc ctgactgcaa   2460

atgatcagcc cgcctcagcc acccaaagtg ttgggattac aggtgtgagc cactgtgccc   2520

agcgtgattt tttttttttt ttaaagcaaa cttgtccttt ggttttgcag aacaggcctg   2580

ctccctctca tctagcccac catttcttgg ggcctgaacc ccagtggtcc aaagtattgc   2640

ttgtgaaatt taaaaaatgt gaatatgatg tggggatggg cctcttctac attaccttgg   2700

cccaggggga tcagctggct gggaggatta gtgagcacct ctgtattttg aggtctgagt   2760

cttctggagc tgtgtagtta atcttcggtt tctgataacc cctgggtcca tctggccatc   2820

agcctcagca gtgagcaaag caataccata ctcatttcta tgttcctgtt ccttcctctg   2880

ctcctccttt ggagaagcaa taattcatgg gggatgatac agtagcactt tacaaatggc   2940

tccatgtcat tcatcccagg ggccataatc tcttgcacca cctattctta cttcctgttc   3000

agctccttta cagcttttat tttcaactgc ttcccaactt ggtggggcct cctttaagga   3060

tgagccaata gtaagaatgt ggctgtaatc agcagagacc cctctgaggg gtatctgttc   3120

tgcagcccct agtgaaatca tgtgatgtga gacagaaacc taaacatggt acttgattct   3180

aaacctgtgc cagtctatag cctctgcctc cccaagcaga gctcaagcca aacgcttctg   3240

tcctctttcc ttctgcatta accctttgct gatcctcagg ggccactccc ccaacacccc   3300

tgtacttggg tgagggatgt tggacagagc ctgttttcat gtactgcagg tgggggtgtg   3360

ctgacatgtt tgctcttggt tgatggagaa ggtacagagg ccagggagtg aaaatggttg   3420

acagaagagg gaagagttag gtgtctcata gtcactcata gtggggtggt caggggtaat   3480

ggcatctccc cactttaggc ttctcaaaca gacttttgac acctctcaag ttcagagctc   3540

tgatgtggaa agacaggagg tgtggggaag gagggggatt tcgtgtgttt gcatgagtgt   3600

gcgcttcagg ccttgggagt tggcaagagg gagggaagga aggagagcaa aatcttcgga   3660

atgtgtttct tgtacctgag ggatcctgcc ctgaatctcc atagtctcca ctgtgaactg   3720

aggaggggag gggtgtgctg gggaataaat cttgtatgag aacaaaaaaa aaaaaaaaa    3779


<210>  3501
<211>  466
<212>  PRT
<213>  Homosapiens

<400>  3501

Met Ala Glu Ala Glu Gly Val Pro Thr Thr Pro Gly Pro Ala Ser Gly 
1               5                   10                  15      


Ser Thr Phe Arg Gly Arg Arg Asp Val Ser Gly Ser Trp Glu Arg Asp 
            20                  25                  30          


Gln Gln Val Glu Ala Ala Gln Arg Ala Leu Val Glu Val Leu Gly Pro 
        35                  40                  45              


Tyr Glu Pro Leu Leu Ser Arg Val Gln Ala Ala Leu Val Trp Glu Arg 
    50                  55                  60                  


Pro Ala Arg Ser Ala Leu Trp Cys Leu Gly Leu Asn Ala Ala Phe Trp 
65                  70                  75                  80  


Phe Phe Ala Leu Thr Ser Leu Arg Leu Val Phe Leu Leu Ala Phe Gly 
                85                  90                  95      


Leu Met Ile Ile Val Cys Ile Asp Gln Trp Lys Asn Lys Ile Trp Pro 
            100                 105                 110         


Glu Ile Lys Val Pro Arg Pro Asp Ala Leu Asp Asn Glu Ser Trp Gly 
        115                 120                 125             


Phe Val His Pro Arg Leu Leu Ser Val Pro Glu Leu Cys His His Val 
    130                 135                 140                 


Ala Glu Val Trp Val Ser Gly Thr Ile Phe Ile Arg Asn Val Leu Leu 
145                 150                 155                 160 


Phe Lys Lys Gln Asn Pro Gly Lys Phe Cys Leu Leu Ser Cys Gly Ile 
                165                 170                 175     


Leu Thr Phe Leu Ala Val Leu Gly Arg Tyr Val Pro Gly Leu Leu Leu 
            180                 185                 190         


Ser Tyr Leu Met Leu Val Thr Val Met Met Trp Pro Leu Ala Val Tyr 
        195                 200                 205             


His Arg Leu Trp Asp Arg Ala Tyr Val Arg Leu Lys Pro Ala Leu Gln 
    210                 215                 220                 


Arg Leu Asp Phe Ser Val Arg Gly Tyr Met Met Ser Lys Gln Arg Glu 
225                 230                 235                 240 


Arg Gln Leu Arg Arg Arg Ala Leu His Pro Glu Arg Ala Met Asp Asn 
                245                 250                 255     


His Ser Asp Ser Glu Glu Glu Leu Ala Ala Phe Cys Pro Gln Leu Asp 
            260                 265                 270         


Asp Ser Thr Val Ala Arg Glu Leu Ala Ile Thr Asp Ser Glu His Ser 
        275                 280                 285             


Asp Ala Glu Val Ser Cys Thr Asp Asn Gly Thr Phe Asn Leu Ser Arg 
    290                 295                 300                 


Gly Gln Thr Pro Leu Thr Glu Gly Ser Glu Asp Leu Asp Gly His Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Ser Phe Ala Arg Asp Leu Pro Asp Phe Pro Ser Ile 
                325                 330                 335     


Asn Met Asp Pro Ala Gly Leu Asp Asp Glu Asp Asp Thr Ser Ile Gly 
            340                 345                 350         


Met Pro Ser Leu Met Tyr Arg Ser Pro Pro Gly Ala Glu Glu Pro Gln 
        355                 360                 365             


Ala Pro Pro Ala Ser Arg Asp Glu Ala Ala Leu Pro Glu Leu Leu Leu 
    370                 375                 380                 


Gly Ala Leu Pro Val Gly Ser Asn Leu Thr Ser Asn Leu Ala Ser Leu 
385                 390                 395                 400 


Val Ser Gln Gly Met Ile Gln Leu Ala Leu Ser Gly Ala Ser Gln Pro 
                405                 410                 415     


Gly Pro Ser Gly Ala Pro Ala Gln Arg Ala Thr Arg Gly Phe Leu Arg 
            420                 425                 430         


Ser Pro Ser Ser Asp Leu Asp Thr Asp Ala Glu Gly Asp Asp Phe Glu 
        435                 440                 445             


Leu Leu Asp Gln Ser Glu Leu Ser Gln Leu Asp Pro Ala Ser Ser Arg 
    450                 455                 460                 


Ser His 
465     


<210>  3502
<211>  1645
<212>  DNA
<213>  Homosapiens

<400>  3502
gcgggctggc gtgcggcgcc gttgcgggcg ggagcggctg caacgccggt gcctgaggag     60

cgatgccgag ggaaatcatc accctacagt tgggccagtg cggcaatcag attgggttcg    120

agttctggaa acagctgtgc gccgagcatg gtatcagccc cgagggcatc gtggaggagt    180

tcgccaccga gggcactgac cgcaaggacg tctttttcta ccaggcagac gatgagcact    240

acatcccccg ggccgtgctg ctggacttgg aaccccgggt gatccactcc atcctcaact    300

ccccctatgc caagctctac aacccagaga acatctacct gtcggaacat ggaggaggag    360

ctggcaacaa ctgggccagc ggattctccc agggagaaaa gatccatgag gacatttttg    420

acatcataga ccgggaggca gatggtagtg acagtctaga gggctttgtg ctgtgtcact    480

ccattgctgg ggggacaggc tctggactgg gttcctacct cttagaacgg ctgaatgaca    540

ggtatcctaa gaagctggtg cagacatact cagtgtttcc caaccaggac gagatgagcg    600

atgtggtggt ccagccttac aattcactcc tcacactcaa gaggctgacg cagaatgcag    660

actgtgtggt ggtgctggac aacacagccc tgaaccggat tgccacagac cgcctgcaca    720

tccagaaccc atccttctcc cagatcaacc agctggtgtc taccatcatg tcagccagca    780

ccaccaccct gcgctaccct ggctacatga acaatgacct catcggcctc atcgcctcgc    840

tcattcccac cccacggctc cacttcctca tgaccggcta cacccctctc actacggacc    900

agtcagtggc cagcgtgagg aagaccacgg tcctggatgt catgaggcgg ctgctgcagc    960

ccaagaacgt gatggtgtcc acaggccgag accgccagac caaccactgc tacatcgcca   1020

tcctcaacat catccaggga gaggtggacc ccacccaggt ccacaagagc ttgcagagga   1080

tccgggaacg caagttggcc aacttcatcc cgtggggccc cgccagcatc caggtggccc   1140

tgtcgaggaa gtctccctac ctgccctcgg cccaccgggt cagcgggctc atgatggcca   1200

accacaccag catctcctcg ctcttcgaga gaacctgtcg ccagtatgac aagctgcgta   1260

agcgggaggc cttcctggag cagttccgca aggaggacat gttcaaggac aactttgatg   1320

agatggacac atccagggag attgtgcagc agctcatcga tgagtaccat gcggccacac   1380

ggccagacta catctcctgg ggcacccagg agcagtgagt cccccaggac agggaccctc   1440

atctgcctta ctggttggcc caagccctgc ctgactgacc accccctcag agcacagatc   1500

agggacctca cgcatctctt tctcatatac atggactctc tgttggcctg caaacacatt   1560

tacttctcct cttatgagac tatttatctt taataaagca ctggatataa aaaaaaaaaa   1620

aaaaaaaaaa aaaaaaaaaa aaaaa                                         1645


<210>  3503
<211>  451
<212>  PRT
<213>  Homosapiens

<400>  3503

Met Pro Arg Glu Ile Ile Thr Leu Gln Leu Gly Gln Cys Gly Asn Gln 
1               5                   10                  15      


Ile Gly Phe Glu Phe Trp Lys Gln Leu Cys Ala Glu His Gly Ile Ser 
            20                  25                  30          


Pro Glu Gly Ile Val Glu Glu Phe Ala Thr Glu Gly Thr Asp Arg Lys 
        35                  40                  45              


Asp Val Phe Phe Tyr Gln Ala Asp Asp Glu His Tyr Ile Pro Arg Ala 
    50                  55                  60                  


Val Leu Leu Asp Leu Glu Pro Arg Val Ile His Ser Ile Leu Asn Ser 
65                  70                  75                  80  


Pro Tyr Ala Lys Leu Tyr Asn Pro Glu Asn Ile Tyr Leu Ser Glu His 
                85                  90                  95      


Gly Gly Gly Ala Gly Asn Asn Trp Ala Ser Gly Phe Ser Gln Gly Glu 
            100                 105                 110         


Lys Ile His Glu Asp Ile Phe Asp Ile Ile Asp Arg Glu Ala Asp Gly 
        115                 120                 125             


Ser Asp Ser Leu Glu Gly Phe Val Leu Cys His Ser Ile Ala Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Leu Gly Ser Tyr Leu Leu Glu Arg Leu Asn Asp Arg 
145                 150                 155                 160 


Tyr Pro Lys Lys Leu Val Gln Thr Tyr Ser Val Phe Pro Asn Gln Asp 
                165                 170                 175     


Glu Met Ser Asp Val Val Val Gln Pro Tyr Asn Ser Leu Leu Thr Leu 
            180                 185                 190         


Lys Arg Leu Thr Gln Asn Ala Asp Cys Val Val Val Leu Asp Asn Thr 
        195                 200                 205             


Ala Leu Asn Arg Ile Ala Thr Asp Arg Leu His Ile Gln Asn Pro Ser 
    210                 215                 220                 


Phe Ser Gln Ile Asn Gln Leu Val Ser Thr Ile Met Ser Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Leu Arg Tyr Pro Gly Tyr Met Asn Asn Asp Leu Ile Gly Leu 
                245                 250                 255     


Ile Ala Ser Leu Ile Pro Thr Pro Arg Leu His Phe Leu Met Thr Gly 
            260                 265                 270         


Tyr Thr Pro Leu Thr Thr Asp Gln Ser Val Ala Ser Val Arg Lys Thr 
        275                 280                 285             


Thr Val Leu Asp Val Met Arg Arg Leu Leu Gln Pro Lys Asn Val Met 
    290                 295                 300                 


Val Ser Thr Gly Arg Asp Arg Gln Thr Asn His Cys Tyr Ile Ala Ile 
305                 310                 315                 320 


Leu Asn Ile Ile Gln Gly Glu Val Asp Pro Thr Gln Val His Lys Ser 
                325                 330                 335     


Leu Gln Arg Ile Arg Glu Arg Lys Leu Ala Asn Phe Ile Pro Trp Gly 
            340                 345                 350         


Pro Ala Ser Ile Gln Val Ala Leu Ser Arg Lys Ser Pro Tyr Leu Pro 
        355                 360                 365             


Ser Ala His Arg Val Ser Gly Leu Met Met Ala Asn His Thr Ser Ile 
    370                 375                 380                 


Ser Ser Leu Phe Glu Arg Thr Cys Arg Gln Tyr Asp Lys Leu Arg Lys 
385                 390                 395                 400 


Arg Glu Ala Phe Leu Glu Gln Phe Arg Lys Glu Asp Met Phe Lys Asp 
                405                 410                 415     


Asn Phe Asp Glu Met Asp Thr Ser Arg Glu Ile Val Gln Gln Leu Ile 
            420                 425                 430         


Asp Glu Tyr His Ala Ala Thr Arg Pro Asp Tyr Ile Ser Trp Gly Thr 
        435                 440                 445             


Gln Glu Gln 
    450     


<210>  3504
<211>  624
<212>  DNA
<213>  Homosapiens

<400>  3504
atggctaaag gtgaccccaa gaaaccaaag ggcaagatgt ctgcttatgc cttctttgtg     60

cagacgtgca gagaagaaca taagaagaaa aacccaaaag tccccatcaa ttttgcagaa    120

ttttccaaaa agtgctctga gaggtggaag acaatgtcca agaaagagaa atctaaattc    180

aatgaactgg caaaggcgga taaagtgcac tatgatcagg aaattaagga ttatggacca    240

gctaaaggag gcaagaagaa ggatcctaat gcccccaaaa ggccaccgtc tggattcttc    300

ctgttctgtt cagaattctg ccccaagagc aaatccacaa accccggcat ccctattgga    360

gacgtggcaa aaaagctggg tgagatgtgg aagaacttaa atgacagtga aaagcagcct    420

tacatcactc aggcggcaaa gctgaaggaa aagtatgaga aggatgttgc tgtctataag    480

tcgaaaggaa agtctgatgg cgcaaagggt cctgctaaag ttgcccagaa aaaggtggaa    540

gaggaagatg aagacgagga gttctgtatt ctacactcgg tgctaacttt ttggtatgtc    600

tattgccttc acaaaaccat atga                                           624


<210>  3505
<211>  207
<212>  PRT
<213>  Homosapiens

<400>  3505

Met Ala Lys Gly Asp Pro Lys Lys Pro Lys Gly Lys Met Ser Ala Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys Asn Pro 
            20                  25                  30          


Lys Val Pro Ile Asn Phe Ala Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Lys Lys Glu Lys Ser Lys Phe Asn Glu Leu Ala 
    50                  55                  60                  


Lys Ala Asp Lys Val His Tyr Asp Gln Glu Ile Lys Asp Tyr Gly Pro 
65                  70                  75                  80  


Ala Lys Gly Gly Lys Lys Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro 
                85                  90                  95      


Ser Gly Phe Phe Leu Phe Cys Ser Glu Phe Cys Pro Lys Ser Lys Ser 
            100                 105                 110         


Thr Asn Pro Gly Ile Pro Ile Gly Asp Val Ala Lys Lys Leu Gly Glu 
        115                 120                 125             


Met Trp Lys Asn Leu Asn Asp Ser Glu Lys Gln Pro Tyr Ile Thr Gln 
    130                 135                 140                 


Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Val Ala Val Tyr Lys 
145                 150                 155                 160 


Ser Lys Gly Lys Ser Asp Gly Ala Lys Gly Pro Ala Lys Val Ala Gln 
                165                 170                 175     


Lys Lys Val Glu Glu Glu Asp Glu Asp Glu Glu Phe Cys Ile Leu His 
            180                 185                 190         


Ser Val Leu Thr Phe Trp Tyr Val Tyr Cys Leu His Lys Thr Ile 
        195                 200                 205         


<210>  3506
<211>  1830
<212>  DNA
<213>  Homosapiens

<400>  3506
aagcttacga ggaattcttg gatgacatcc ctcagcatgt ctgagcgact gctgagggag     60

aaaatgatgc ccaggttggt ccccggccca ccgcagagag gcctgcgctg cacacgcgca    120

gaccgagcat ccgcgtcaag aggcgaagag agcgcgcgct ccccacgtcc tgcgctcctg    180

gctgccgggc attcgtctca gccgtgactc tcgccaggcc ggggctggcg cgcccacgtc    240

tgaagagcga tgccccggga gatcatcacc ctgcagctgg gccagtgcgg caaccagatt    300

gggttcgagt tctggaaaca gctgtgcgcc gagcatggta tcagccccga gggcatcgtg    360

gaggagttcg ccaccgaggg cactgaccgc aaggacgtct ttttctacca ggcagacgat    420

gagcactaca tcccccgggc cgtgctgctg gacttggaac cccgggtgat ccactccatc    480

ctcaactccc cctatgccaa gctctacaac ccagagaaca tctacctgtc ggaacatgga    540

ggaggagctg gcaacaactg ggccagcgga ttctcccagg gtgagaaaat tcatgaagac    600

atctttgaca tcatagaccg agaagcagat ggaagtgaca gtttggaggg cttcgtgctg    660

tgtcactcca tcgctggggg tacgggttct ggcctgggct cctacctcct ggagcgactg    720

aatgacaggt accccaagaa gctagtgcag acttattcag tgtttcccta ccaggacgag    780

atgagcgacg tagtggttca gccctacaat tcactcctga cactcaagag gctgacgcag    840

aacgcagatt gtgtggtggt gctggacaac acagccctga accggattgc cacagaccgc    900

ctgcacatcc agaacccgtc cttctcccag atcaaccagc tggtgtccac catcatgtcg    960

gccagcacca ccaccctgcg ctaccccggc tacatgaaca atgacctcat cggcctcatc   1020

gcctcgctca ttcccacccc acggctccac tttctcatga ccggctacac cccgctcact   1080

acagaccagt cagtggccag cgtgaggaag accacggtcc tggatgtcat gaggcggctg   1140

ctgcagccca agaacgtgat ggtgtccaca ggccgagacc gccagaccaa ccactgctac   1200

atcgccatcc tcaacatcat ccagggagag gtggacccca cccaggtcca caagagcctg   1260

cagaggatcc gggaacggaa gttggccaac ttcatcccgt ggggccccgc cagcatccag   1320

gtggccctgt cgaggaagtc tccctacctg ccctcggccc accgggtcag cgggctcatg   1380

atggccaacc acaccagcat ctcctcgctc tttgaaagtt cctgccagca gtttgacaag   1440

ctgcggaagc gggatgcctt cctcgagcag ttccgtaagg aggacatgtt caaggacaac   1500

tttgatgaga tggacaggtc tagggaggtt gttcaggagc tcattgatga gtaccatgcg   1560

gccacccagc cagactacat ttcctggggc acccaggagc agtgatttcc ctccccacta   1620

ctccttctcc ttctagatgg taaccacagc ctcgaccatg cctgctccct ctgacccagc   1680

ttcacctcat ggacaaccct tcttggttca tctccagccc gtgagctggt cctgcttcct   1740

cccttccatg ccctaacttt taatatgctt gttcagctct aataaagtaa taaagcttgg   1800

ttgtcagtat aaaaaaaaaa aaaaaaaaaa                                    1830


<210>  3507
<211>  451
<212>  PRT
<213>  Homosapiens

<400>  3507

Met Pro Arg Glu Ile Ile Thr Leu Gln Leu Gly Gln Cys Gly Asn Gln 
1               5                   10                  15      


Ile Gly Phe Glu Phe Trp Lys Gln Leu Cys Ala Glu His Gly Ile Ser 
            20                  25                  30          


Pro Glu Gly Ile Val Glu Glu Phe Ala Thr Glu Gly Thr Asp Arg Lys 
        35                  40                  45              


Asp Val Phe Phe Tyr Gln Ala Asp Asp Glu His Tyr Ile Pro Arg Ala 
    50                  55                  60                  


Val Leu Leu Asp Leu Glu Pro Arg Val Ile His Ser Ile Leu Asn Ser 
65                  70                  75                  80  


Pro Tyr Ala Lys Leu Tyr Asn Pro Glu Asn Ile Tyr Leu Ser Glu His 
                85                  90                  95      


Gly Gly Gly Ala Gly Asn Asn Trp Ala Ser Gly Phe Ser Gln Gly Glu 
            100                 105                 110         


Lys Ile His Glu Asp Ile Phe Asp Ile Ile Asp Arg Glu Ala Asp Gly 
        115                 120                 125             


Ser Asp Ser Leu Glu Gly Phe Val Leu Cys His Ser Ile Ala Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Leu Gly Ser Tyr Leu Leu Glu Arg Leu Asn Asp Arg 
145                 150                 155                 160 


Tyr Pro Lys Lys Leu Val Gln Thr Tyr Ser Val Phe Pro Tyr Gln Asp 
                165                 170                 175     


Glu Met Ser Asp Val Val Val Gln Pro Tyr Asn Ser Leu Leu Thr Leu 
            180                 185                 190         


Lys Arg Leu Thr Gln Asn Ala Asp Cys Val Val Val Leu Asp Asn Thr 
        195                 200                 205             


Ala Leu Asn Arg Ile Ala Thr Asp Arg Leu His Ile Gln Asn Pro Ser 
    210                 215                 220                 


Phe Ser Gln Ile Asn Gln Leu Val Ser Thr Ile Met Ser Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Leu Arg Tyr Pro Gly Tyr Met Asn Asn Asp Leu Ile Gly Leu 
                245                 250                 255     


Ile Ala Ser Leu Ile Pro Thr Pro Arg Leu His Phe Leu Met Thr Gly 
            260                 265                 270         


Tyr Thr Pro Leu Thr Thr Asp Gln Ser Val Ala Ser Val Arg Lys Thr 
        275                 280                 285             


Thr Val Leu Asp Val Met Arg Arg Leu Leu Gln Pro Lys Asn Val Met 
    290                 295                 300                 


Val Ser Thr Gly Arg Asp Arg Gln Thr Asn His Cys Tyr Ile Ala Ile 
305                 310                 315                 320 


Leu Asn Ile Ile Gln Gly Glu Val Asp Pro Thr Gln Val His Lys Ser 
                325                 330                 335     


Leu Gln Arg Ile Arg Glu Arg Lys Leu Ala Asn Phe Ile Pro Trp Gly 
            340                 345                 350         


Pro Ala Ser Ile Gln Val Ala Leu Ser Arg Lys Ser Pro Tyr Leu Pro 
        355                 360                 365             


Ser Ala His Arg Val Ser Gly Leu Met Met Ala Asn His Thr Ser Ile 
    370                 375                 380                 


Ser Ser Leu Phe Glu Ser Ser Cys Gln Gln Phe Asp Lys Leu Arg Lys 
385                 390                 395                 400 


Arg Asp Ala Phe Leu Glu Gln Phe Arg Lys Glu Asp Met Phe Lys Asp 
                405                 410                 415     


Asn Phe Asp Glu Met Asp Arg Ser Arg Glu Val Val Gln Glu Leu Ile 
            420                 425                 430         


Asp Glu Tyr His Ala Ala Thr Gln Pro Asp Tyr Ile Ser Trp Gly Thr 
        435                 440                 445             


Gln Glu Gln 
    450     


<210>  3508
<211>  2994
<212>  DNA
<213>  Homosapiens

<400>  3508
cggccaccgg acgccctacc ggacacgacc ctccctggag cttggacaac tgcccacctc     60

ggacgctgca ccggacactg ccccccacag ggctggacac tccaacggac actacttccc    120

agctccggac attgctccct cctctcccgg ggccctggac gcttttcccc ctcccccctc    180

cgggggccca gacactgagc ccccctcagc gtctggctag cgtccccttg caccccagcc    240

caggacactg cctcctccct gtcctcttct cccttctgct cctcccacct catctttccc    300

ctgctcgggt cggagccccg ccagttcctc cgacccccta ctgctcggcc gcggctgccc    360

gcgcccccat ccgcagctcc tcgcccggat gcctctcccc gggggactat ggtggcttct    420

ctgctgccgt cgaggcttca ctcttctgca ccgggactac ggggacggcg agcttagcgg    480

ggacggggac gaggacgagg acgaggaaac ctttgagctg cggaccccga gtccagcggg    540

cggcgggagg ggtcccctgg aagtgacgct gactcagcca gtgaggagcg ggcctgtctc    600

caacaggctg cagagctggg aggagacttg gagcctcatc ccggagaaag ggctgccgga    660

ggacgacccg gacatcgttg tgaaaggttg gctgtaccgg gagccccgcg gaggaggggc    720

gcggccctgg ctgcccccgc gccgagcctg gtttgtgctc acgcgggact ccctggatca    780

gttcagcagc agcgggaaag gggcgcggcg tctcgggagc ctcgtgctca ccagcctgtg    840

ctcggtgacc ggcccagagc gcaggcgtaa ggagacaggt ctgtggtcag tgactgtgtc    900

tggtcggaaa cacagtgtcc gcctctgctc cccacgccag gcagaggctg agcgctgggg    960

ggtggcattg cgggaagtga tcgcctccaa ggcacccctg gagaccccca cccagctact   1020

gctcagggac atacaggaaa gttgcgggga cccagaggcc gttgccctca tttacctgag   1080

gaacccgatt ctgagacaca ctagtggagc cttgtatgcc ccactcctgc ccctgcccta   1140

tggagtcagc gccccaggtc cgggctatgc acccctgcgc gaggaggcgg tgcggctgtt   1200

cttggcgctg caggcgctgg agggggcgcg gcgccccggg cccttgatgc agggtgtgct   1260

ccaaacctgc cgggacttgc ccgcgctccg ggatgaactc ttcctgcagc tggctaagca   1320

gacctcgggc cctgcaggtc cccccgggct cccggctacc caagaccctg cggccctgcg   1380

gtactggcaa ctcctcacct gcatgagctg caccttccga cctgggggag ctgtgcgggg   1440

gcacctcctg gggcacttgg agaggaccga gcaggcactc ccggactcgg aactggcgga   1500

atatgcgcgc ttcatccgga aagcgctggg ccggacgcgc ggcagagagc tggtgccctc   1560

gctggcggag atttccgcgt tgagccaacg gcaggagctg ctgtgtaccg tgcactgtcc   1620

gggggctggt gcctgtgctg tggccatcga ctcccacacc acggcggggg aggtggctcg   1680

agagctggtg gggcggctgg gcttggcccg gagccgcaac gcattcgcgc tgtacgagca   1740

gcgaggggcc caggagcgag ccctggctgg ggggaccctc gtggccgacg tgctcaccag   1800

gtttgagaac ttggccgcgg aggaagctgg gttggaggac tcgcccgact ccgggtggag   1860

actatgtctg cgtcttcacg gacctctgca ccctgagggg ctgtccccag acggtcacga   1920

actgcctttc ctctttgagc aggctcacgc tctgctgctg cggggccggc cgcccccacc   1980

cgacgacacg ctgcgcgccc tggcggcgct gcgcctgcag agcctgcatc gggacttctc   2040

tccgcgggtg cccctgcccc gcctggaccg cctgctcccg cccccggccc cgccgcgcga   2100

agacccgccc cgcccgaccc ccaggccgcc cccttccgct gccctgctgg ccggggcgct   2160

ctggagcccg ggcctggcca agaggcgggc ggagcgggcc cggcgcggcg gggccggccg   2220

cactgcggga agcattgccc gcgagggagg aggcggcgcc ggcacggcag ctgccgtgct   2280

gggcggctgg aagcggctac ggggcatggg ccgagctgag gccatggccg cctacctggc   2340

cctggcggcg cagtgtccgg ggttcggcgc tgctcggtat gacgttctgg agctgagcac   2400

ggagcctggt cggggtgctc cacagaagct gtgcctgggc ttgggagcca aggccatgtc   2460

cctctcccgg ccaggggaga cggagcccat ccacagtgtc agctatggcc atgtggccgc   2520

ctgccagcta atgggccccc acaccctggc cttgagggtg ggagagagcc agctcctcct   2580

gcagagcccc caggtggaag agatcatgca gctggtgaat gcctacttgg ccaacccctc   2640

ccccgagagg ccctgcagca gctcttctcc tccatgccaa gacctgccag acacctcccc   2700

tcccagccag cgcccgggcc tggacgagcc ccagggacag tctggctgct tggggcagct   2760

gcaggactga gcctgccaag aggtcacgac ttccctcctg cctgcagcct gggccaggac   2820

tgctctgaga tttgagggaa acatggaccc ttttggccct gcagggacag ggcacatccc   2880

acacccaagg gctacaatgg gtgtgggtaa ttttctagtt tgtttcttaa tttatttgta   2940

gaagagaagc aaaaaaaaaa aaaagtttct tatttacaca aaaaaaaaaa aaaa         2994


<210>  3509
<211>  793
<212>  PRT
<213>  Homosapiens

<400>  3509

Met Pro Leu Pro Gly Gly Leu Trp Trp Leu Leu Cys Cys Arg Arg Gly 
1               5                   10                  15      


Phe Thr Leu Leu His Arg Asp Tyr Gly Asp Gly Glu Leu Ser Gly Asp 
            20                  25                  30          


Gly Asp Glu Asp Glu Asp Glu Glu Thr Phe Glu Leu Arg Thr Pro Ser 
        35                  40                  45              


Pro Ala Gly Gly Gly Arg Gly Pro Leu Glu Val Thr Leu Thr Gln Pro 
    50                  55                  60                  


Val Arg Ser Gly Pro Val Ser Asn Arg Leu Gln Ser Trp Glu Glu Thr 
65                  70                  75                  80  


Trp Ser Leu Ile Pro Glu Lys Gly Leu Pro Glu Asp Asp Pro Asp Ile 
                85                  90                  95      


Val Val Lys Gly Trp Leu Tyr Arg Glu Pro Arg Gly Gly Gly Ala Arg 
            100                 105                 110         


Pro Trp Leu Pro Pro Arg Arg Ala Trp Phe Val Leu Thr Arg Asp Ser 
        115                 120                 125             


Leu Asp Gln Phe Ser Ser Ser Gly Lys Gly Ala Arg Arg Leu Gly Ser 
    130                 135                 140                 


Leu Val Leu Thr Ser Leu Cys Ser Val Thr Gly Pro Glu Arg Arg Arg 
145                 150                 155                 160 


Lys Glu Thr Gly Leu Trp Ser Val Thr Val Ser Gly Arg Lys His Ser 
                165                 170                 175     


Val Arg Leu Cys Ser Pro Arg Gln Ala Glu Ala Glu Arg Trp Gly Val 
            180                 185                 190         


Ala Leu Arg Glu Val Ile Ala Ser Lys Ala Pro Leu Glu Thr Pro Thr 
        195                 200                 205             


Gln Leu Leu Leu Arg Asp Ile Gln Glu Ser Cys Gly Asp Pro Glu Ala 
    210                 215                 220                 


Val Ala Leu Ile Tyr Leu Arg Asn Pro Ile Leu Arg His Thr Ser Gly 
225                 230                 235                 240 


Ala Leu Tyr Ala Pro Leu Leu Pro Leu Pro Tyr Gly Val Ser Ala Pro 
                245                 250                 255     


Gly Pro Gly Tyr Ala Pro Leu Arg Glu Glu Ala Val Arg Leu Phe Leu 
            260                 265                 270         


Ala Leu Gln Ala Leu Glu Gly Ala Arg Arg Pro Gly Pro Leu Met Gln 
        275                 280                 285             


Gly Val Leu Gln Thr Cys Arg Asp Leu Pro Ala Leu Arg Asp Glu Leu 
    290                 295                 300                 


Phe Leu Gln Leu Ala Lys Gln Thr Ser Gly Pro Ala Gly Pro Pro Gly 
305                 310                 315                 320 


Leu Pro Ala Thr Gln Asp Pro Ala Ala Leu Arg Tyr Trp Gln Leu Leu 
                325                 330                 335     


Thr Cys Met Ser Cys Thr Phe Arg Pro Gly Gly Ala Val Arg Gly His 
            340                 345                 350         


Leu Leu Gly His Leu Glu Arg Thr Glu Gln Ala Leu Pro Asp Ser Glu 
        355                 360                 365             


Leu Ala Glu Tyr Ala Arg Phe Ile Arg Lys Ala Leu Gly Arg Thr Arg 
    370                 375                 380                 


Gly Arg Glu Leu Val Pro Ser Leu Ala Glu Ile Ser Ala Leu Ser Gln 
385                 390                 395                 400 


Arg Gln Glu Leu Leu Cys Thr Val His Cys Pro Gly Ala Gly Ala Cys 
                405                 410                 415     


Ala Val Ala Ile Asp Ser His Thr Thr Ala Gly Glu Val Ala Arg Glu 
            420                 425                 430         


Leu Val Gly Arg Leu Gly Leu Ala Arg Ser Arg Asn Ala Phe Ala Leu 
        435                 440                 445             


Tyr Glu Gln Arg Gly Ala Gln Glu Arg Ala Leu Ala Gly Gly Thr Leu 
    450                 455                 460                 


Val Ala Asp Val Leu Thr Arg Phe Glu Asn Leu Ala Ala Glu Glu Ala 
465                 470                 475                 480 


Gly Leu Glu Asp Ser Pro Asp Ser Gly Trp Arg Leu Cys Leu Arg Leu 
                485                 490                 495     


His Gly Pro Leu His Pro Glu Gly Leu Ser Pro Asp Gly His Glu Leu 
            500                 505                 510         


Pro Phe Leu Phe Glu Gln Ala His Ala Leu Leu Leu Arg Gly Arg Pro 
        515                 520                 525             


Pro Pro Pro Asp Asp Thr Leu Arg Ala Leu Ala Ala Leu Arg Leu Gln 
    530                 535                 540                 


Ser Leu His Arg Asp Phe Ser Pro Arg Val Pro Leu Pro Arg Leu Asp 
545                 550                 555                 560 


Arg Leu Leu Pro Pro Pro Ala Pro Pro Arg Glu Asp Pro Pro Arg Pro 
                565                 570                 575     


Thr Pro Arg Pro Pro Pro Ser Ala Ala Leu Leu Ala Gly Ala Leu Trp 
            580                 585                 590         


Ser Pro Gly Leu Ala Lys Arg Arg Ala Glu Arg Ala Arg Arg Gly Gly 
        595                 600                 605             


Ala Gly Arg Thr Ala Gly Ser Ile Ala Arg Glu Gly Gly Gly Gly Ala 
    610                 615                 620                 


Gly Thr Ala Ala Ala Val Leu Gly Gly Trp Lys Arg Leu Arg Gly Met 
625                 630                 635                 640 


Gly Arg Ala Glu Ala Met Ala Ala Tyr Leu Ala Leu Ala Ala Gln Cys 
                645                 650                 655     


Pro Gly Phe Gly Ala Ala Arg Tyr Asp Val Leu Glu Leu Ser Thr Glu 
            660                 665                 670         


Pro Gly Arg Gly Ala Pro Gln Lys Leu Cys Leu Gly Leu Gly Ala Lys 
        675                 680                 685             


Ala Met Ser Leu Ser Arg Pro Gly Glu Thr Glu Pro Ile His Ser Val 
    690                 695                 700                 


Ser Tyr Gly His Val Ala Ala Cys Gln Leu Met Gly Pro His Thr Leu 
705                 710                 715                 720 


Ala Leu Arg Val Gly Glu Ser Gln Leu Leu Leu Gln Ser Pro Gln Val 
                725                 730                 735     


Glu Glu Ile Met Gln Leu Val Asn Ala Tyr Leu Ala Asn Pro Ser Pro 
            740                 745                 750         


Glu Arg Pro Cys Ser Ser Ser Ser Pro Pro Cys Gln Asp Leu Pro Asp 
        755                 760                 765             


Thr Ser Pro Pro Ser Gln Arg Pro Gly Leu Asp Glu Pro Gln Gly Gln 
    770                 775                 780                 


Ser Gly Cys Leu Gly Gln Leu Gln Asp 
785                 790             


<210>  3510
<211>  1244
<212>  DNA
<213>  Homosapiens

<400>  3510
agagatgggg acggaggcca cagagcaggt ttcctggggc cattactctg gggatgaaga     60

ggacgcatac tcggctgagc cactgccgga gctttgctac aaggccgatg tccaggcctt    120

cagccgggcc ttccaaccca gtgtctccct gaccgtggct gcgctgggtc tggccggcaa    180

tggcctggtc ctggccaccc acctggcagc ccgacgcgca gcgcgctcgc ccacctctgc    240

ccacctgctc cagctggccc tggccgacct cttgctggcc ctgactctgc ccttcgcggc    300

agcaggggct cttcagggct ggagtctggg aagtgccacc tgccgcacca tctctggcct    360

ctactcggcc tccttccacg ccggcttcct cttcctggcc tgtatcagcg ccgaccgcta    420

cgtggccatc gcgcgagcgc tcccagccgg gccgcggccc tccactcccg gccgcgcaca    480

cttggtctcc gtcatcgtgt ggctgctgtc actgctcctg gcgctgcctg cgctgctctt    540

cagccaggat gggcagcggg aaggccaacg acgctgtcgc ctcatcttcc ccgagggcct    600

cacgcagacg gtgaaggggg cgagcgccgt ggcgcaggtg gccctgggct tcgcgctgcc    660

gctgggcgtc atggtagcct gctacgcgct tctgggccgc acgctgctgg ccgccagggg    720

gcccgagcgc cggcgtgcgc tgcgcgtcgt ggtggctctg gtggcggcct tcgtggtgct    780

gcagctgccc tacagcctcg ccctgctgct ggatactgcc gatctactgg ctgcgcgcga    840

gcggagctgc cctgccagca aacgcaagga tgtcgcactg ctggtgacca gcggcttggc    900

cctcgcccgc tgtggcctca atcccgttct ctacgccttc ctgggcctgc gcttccgcca    960

ggacctgcgg aggctgctac ggggtgggag ctcgccctca gggcctcaac cccgccgcgg   1020

ctgcccccgc cggccccgcc tttcttcctg ctcagctccc acggagaccc acagtctctc   1080

ctgggacaac tagggctgcg aatctagagg agggggcagg ctgagggtcg tgggaaaggg   1140

gagtaggtgg gggaacactg agaaagaggc agggacctaa agggactacc tctgtgcctt   1200

gccacattaa attgataaca tggaaatgaa aaaaaaaaaa aaaa                    1244


<210>  3511
<211>  362
<212>  PRT
<213>  Homosapiens

<400>  3511

Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser 
        35                  40                  45              


Leu Thr Val Ala Ala Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala 
    50                  55                  60                  


Thr His Leu Ala Ala Arg Arg Ala Ala Arg Ser Pro Thr Ser Ala His 
65                  70                  75                  80  


Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Thr Leu Pro 
                85                  90                  95      


Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Ser Leu Gly Ser Ala Thr 
            100                 105                 110         


Cys Arg Thr Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe 
        115                 120                 125             


Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg 
    130                 135                 140                 


Ala Leu Pro Ala Gly Pro Arg Pro Ser Thr Pro Gly Arg Ala His Leu 
145                 150                 155                 160 


Val Ser Val Ile Val Trp Leu Leu Ser Leu Leu Leu Ala Leu Pro Ala 
                165                 170                 175     


Leu Leu Phe Ser Gln Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg 
            180                 185                 190         


Leu Ile Phe Pro Glu Gly Leu Thr Gln Thr Val Lys Gly Ala Ser Ala 
        195                 200                 205             


Val Ala Gln Val Ala Leu Gly Phe Ala Leu Pro Leu Gly Val Met Val 
    210                 215                 220                 


Ala Cys Tyr Ala Leu Leu Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro 
225                 230                 235                 240 


Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala Ala Phe 
                245                 250                 255     


Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Thr Ala 
            260                 265                 270         


Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys 
        275                 280                 285             


Asp Val Ala Leu Leu Val Thr Ser Gly Leu Ala Leu Ala Arg Cys Gly 
    290                 295                 300                 


Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Gln Asp 
305                 310                 315                 320 


Leu Arg Arg Leu Leu Arg Gly Gly Ser Ser Pro Ser Gly Pro Gln Pro 
                325                 330                 335     


Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro 
            340                 345                 350         


Thr Glu Thr His Ser Leu Ser Trp Asp Asn 
        355                 360         


<210>  3512
<211>  5293
<212>  DNA
<213>  Homosapiens

<400>  3512
caagagcgga ggaccaggaa ccagagagag agagagagaa aagagagagg agagacagag     60

cgcttggggg cgaaaggaga gagggaggga agggtgggta aggaggagag agcggtctgc    120

tgcaaacccc aggaggagag cttggagccc aagccagaac tcgagcccta gccggagccg    180

ttcacaggga ggcggctgcc gggaccgtca gccctgcatg atgcatctcc ggctcttctg    240

catcctgctc gccgcggtct caggagccga gggctggggc tactacggct gcgacgagga    300

gctggtgggt cccctgtatg cacgctccct gggcgcctcc tcctactaca gtctccttac    360

tgcgccgcga ttcgccaggc tgcacggcat aagcgggtgg tcaccacgga ttggggatcc    420

gaatccctgg ctccagatag acttaatgaa gaagcaccgg atccgggccg tggccacaca    480

gggctccttt aattcttggg actgggtcac acgttacatg ctactctacg gcgaccgagt    540

ggacagctgg acaccgttct accagcgagg gcacaactcg accttctttg gtaacgtgaa    600

cgagtcggcg gtggtgcgcc atgacctgca cttccacttc actgcgcgct acatccgcat    660

cgtgcccctg gcctggaacc cacgcggcaa gatcggcctg aggctcggcc tctatggctg    720

cccatacaag gccgacatac tctatttcga cggcgacgat gccatctcct accgcttccc    780

gcgaggggtc agccgaagcc tgtgggacgt gttcgccttc agcttcaaga ccgaggagaa    840

ggacggtctt ctgctgcacg ccgagggcgc ccagggcgac tacgtgacgc tcgagctgga    900

gggggcacac ctgctgctgc acatgagcct gggcagcagc cctatccagc caagaccagg    960

tcacaccacc gtgagcgcag gcggagtcct caatgaccag cactggcact atgtgcgggt   1020

ggaccgattt ggccgcgatg taaatttcac cctggacggc tatgtgcagc gctttattct   1080

caatggagac ttcgagaggc tgaacctgga cactgagatg ttcatcggag gtctggtggg   1140

cgccgcgcgg aagaacctgg cctatcggca taacttccgc ggctgcatag aaaacgtaat   1200

cttcaaccgc gtcaacatcg cagacctggc cgtgcggcgc cattcccgga tcaccttcga   1260

gggtaaggtg gcttttcgtt gcctggaccc ggtaccgcac cctatcaact tcggaggccc   1320

tcacaacttc gttcaagtgc ccggtttccc acgccgtggc cgcctggcag tctcatttcg   1380

cttccgcacc tgggacctca ccgggcttct ccttttctcc cgtctggggg acgggctggg   1440

ccacgtggag ctgacgctca gcgaagggca ggtcaacgtg tccatcgcgc agagcggccg   1500

aaagaagctt cagttcgctg ctgggtaccg actgaatgac ggcttttggc acgaggtgaa   1560

ttttgtggca caggaaaacc atgcagttat cagcattgat gatgtggaag gggcagaggt   1620

cagggtctca tacccgttgc tgatccggac agggacctca tatttctttg ggggttgtcc   1680

caagccagcc agtcgatggg actgccactc caaccagacg gcattccatg gctgcatgga   1740

gctgctcaag gtggatggtc aactggtcaa cctgactctg gtggagggcc ggcggcttgg   1800

attctatgct gaggtcctct ttgatacatg tggcatcact gataggtgca gccctaacat   1860

gtgtgagcat gatggacgct gctaccagtc ttgggatgac ttcatttgct actgcgaact   1920

gacgggctac aagggagaga cctgccacac acctttgtat aaggaatcct gtgaggctta   1980

tcggctcagt gggaaaactt ctggaaactt caccattgat cctgatggca gtggccccct   2040

gaagccattt gtagtgtact gtgatatccg agagaaccga gcgtggacag ttgtgcggca   2100

tgacaggctg tggacaactc gagtgacagg ttccagcatg gagcggccat tcctgggggc   2160

tatccagtac tggaatgcat cctgggagga agtcagtgcc cttgccaatg cttcccagca   2220

ttgtgaacag tggatcgagt tctcctgcta caattcccgg ctgctcaaca ctgcaggagg   2280

ctacccctac agcttttgga ttggccgaaa tgaggagcag cacttctact ggggaggctc   2340

ccagcctggg atccagcgct gtgcctgtgg tctggaccgg agctgtgtgg accctgcctt   2400

gtactgcaac tgtgacgctg accagcccca gtggagaact gacaagggac tgctgacctt   2460

tgtggaccat ctgcctgtca ctcaggtagt gataggggat acgaaccgct ccacttctga   2520

ggcccagttc ttcctgaggc ctctgcgctg ctatggcgat cgaaattcct ggaacaccat   2580

ttccttccac accggggctg cactacgctt ccccccaatc cgtgccaacc acagcctgga   2640

tgtctccttc tacttcagga cctctgctcc ctcgggggtc ttcctagaga atatgggggg   2700

cccttactgc cagtggcgcc gaccttatgt gcgggtggaa ctcaacacat cccgggatgt   2760

ggtcttcgcc tttgatgtgg ggaatgggga tgagaacctc acagtacact cagacgactt   2820

tgagttcaat gatgacgagt ggcacctggt ccgggctgaa atcaacgtga agcaggcccg   2880

gctccgagtg gatcaccggc cctgggttct gcggcctatg ccactgcaga cctacatctg   2940

gatggagtat gaccagcccc tctatgtggg atctgcagag cttaagagac gcccctttgt   3000

gggttgcttg agggccatgc gtctgaacgg agtgactctg aacctggagg gccgtgccaa   3060

tgcctctgag ggtacctcac ccaactgcac aggccactgt gcccaccctc ggctcccctg   3120

tttccatgga ggccgctgcg tggagcgcta tagctactac acgtgtgact gtgacctcac   3180

ggcttttgat gggccatact gcaaccacga tattggtggt ttctttgagc cgggcacctg   3240

gatgcgctat aacctacagt cagcgctgcg ctctgcagcc agggagttct cccacatgct   3300

gagccggcca gtgccaggct atgagcctgg ctacatcccg ggctatgata ctccgggcta   3360

tgtgcctggc taccatggcc ccgggtaccg cctgcccgac tacccccggc ctggtcggcc   3420

tgtgcccggt taccgtgggc ctgtctacaa cgttacggga gaggaggtct ccttcagctt   3480

cagcaccagc tccgcccctg ctgtcctgct ctacgtcagt tcctttgttc gtgactacat   3540

ggctgtgctc atcaaggatg atgggaccct tcagctgcga tatcagctgg gcaccagtcc   3600

ctacgtgtac cagctaacca ctcgaccagt gaccgatggc cagccccata gcatcaatat   3660

cacccgtgtt taccggaacc tcttcatcca ggtggactac ttcccactga cagagcagaa   3720

gttctcgctg ttggtggaca gccagttgga ctcacccaag gccttgtatt tagggcgtgt   3780

gatggagaca ggagtcattg acccggagat ccagcgctac aacaccccag gtttctcagg   3840

ctgcctgtct ggtgttcgat tcaacaacgt ggctcccctc aagacccact tccgaacccc   3900

tcgacccatg actgctgagc tagctgaggc ccttcgagtt cagggagaac tgtccgaatc   3960

taattgcgga gctatgccac gtcttgtttc agaggtgcca cctgagcttg atccctggta   4020

tctgccccca gacttcccct actaccatga tgaaggatgg gttgccatac ttttaggctt   4080

tttggtggcc tttctgctgc tggggctggt gggaatgttg gtgctcttct atctgcaaaa   4140

tcatcgctat aagggctcct accataccaa tgagcccaag gctgcccacg agtaccatcc   4200

tggcagcaaa cctcccctac ccacttcagg ccctgcccag gtccccaccc ctacagcagc   4260

tcccaaccaa gctccagcct cagccccagc cccagcccca actccagccc cagcccctgg   4320

cccccgggat cagaacctac cccagatcct ggaggagtcc aggtctgaat gagtcagaag   4380

ggcttctggg accaattcca gctcctgaca ttcccccagt cctgcctctc ccccatccta   4440

tcagggacat ttggctcctc ttagctggct ctgctcatcc agaggatatt cccccatccc   4500

ccccccatca agtttggtgg gcagagctac agatgggacc caagggagtg gccgagcctc   4560

actgcctaaa ccaatgccct tctcatccct gtttccccag gctcctggct gtttatctgc   4620

cccaaaggag aagcctcatg gggttgacat aggtcctttc tgccatctct gttccagctg   4680

ctgtcaggga ttaacaacag agtgtagggg agattaactg cctcccttcc aatagacact   4740

atcagcaggg acagatgtgt gggagtgcag ggctgcagag ggtatggggg gaggaggctg   4800

ctaaacccta tcccccagcc tcccccctgc cctgaagatc ttccatttgc ttccactcag   4860

ctggaggctc aagagggctt gatggctgtc ccctgccccc ctccttttgt tttgtacaca   4920

gagaccaaga ggcctcagtt tagcacctta gtacctccgc tgcttcactt gctttagcca   4980

aagccataaa aaacctgcaa cgtagagaaa ataatgcaga taccctgact agccagccct   5040

ctactcctcc aaccttttcc aagatatgca atggcctttg tgcctgccca aaggcttcgc   5100

ccctccagtg catgaggaac cctctttcct ccgctcagag atgctgcttc atttacccag   5160

gaggtcatat tctttatata tattttttgt tgcaaagtgt ctctctagag aaactctata   5220

tattattcga atttttaaat tatttgttta tatataaaag aaaagctcaa ttggcaaaaa   5280

aaaaaaaaaa aaa                                                      5293


<210>  3513
<211>  1384
<212>  PRT
<213>  Homosapiens

<400>  3513

Met Met His Leu Arg Leu Phe Cys Ile Leu Leu Ala Ala Val Ser Gly 
1               5                   10                  15      


Ala Glu Gly Trp Gly Tyr Tyr Gly Cys Asp Glu Glu Leu Val Gly Pro 
            20                  25                  30          


Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Ser Leu Leu Thr 
        35                  40                  45              


Ala Pro Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro Arg 
    50                  55                  60                  


Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys His 
65                  70                  75                  80  


Arg Ile Arg Ala Val Ala Thr Gln Gly Ser Phe Asn Ser Trp Asp Trp 
                85                  90                  95      


Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp Thr 
            100                 105                 110         


Pro Phe Tyr Gln Arg Gly His Asn Ser Thr Phe Phe Gly Asn Val Asn 
        115                 120                 125             


Glu Ser Ala Val Val Arg His Asp Leu His Phe His Phe Thr Ala Arg 
    130                 135                 140                 


Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile Gly 
145                 150                 155                 160 


Leu Arg Leu Gly Leu Tyr Gly Cys Pro Tyr Lys Ala Asp Ile Leu Tyr 
                165                 170                 175     


Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Pro Arg Gly Val Ser 
            180                 185                 190         


Arg Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu Lys 
        195                 200                 205             


Asp Gly Leu Leu Leu His Ala Glu Gly Ala Gln Gly Asp Tyr Val Thr 
    210                 215                 220                 


Leu Glu Leu Glu Gly Ala His Leu Leu Leu His Met Ser Leu Gly Ser 
225                 230                 235                 240 


Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Ala Gly Gly 
                245                 250                 255     


Val Leu Asn Asp Gln His Trp His Tyr Val Arg Val Asp Arg Phe Gly 
            260                 265                 270         


Arg Asp Val Asn Phe Thr Leu Asp Gly Tyr Val Gln Arg Phe Ile Leu 
        275                 280                 285             


Asn Gly Asp Phe Glu Arg Leu Asn Leu Asp Thr Glu Met Phe Ile Gly 
    290                 295                 300                 


Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn Phe 
305                 310                 315                 320 


Arg Gly Cys Ile Glu Asn Val Ile Phe Asn Arg Val Asn Ile Ala Asp 
                325                 330                 335     


Leu Ala Val Arg Arg His Ser Arg Ile Thr Phe Glu Gly Lys Val Ala 
            340                 345                 350         


Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly Pro 
        355                 360                 365             


His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu Ala 
    370                 375                 380                 


Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr Gly Leu Leu Leu Phe 
385                 390                 395                 400 


Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu Leu Thr Leu Ser Glu 
                405                 410                 415     


Gly Gln Val Asn Val Ser Ile Ala Gln Ser Gly Arg Lys Lys Leu Gln 
            420                 425                 430         


Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val Asn 
        435                 440                 445             


Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val Glu 
    450                 455                 460                 


Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Thr Gly Thr 
465                 470                 475                 480 


Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Asp Cys 
                485                 490                 495     


His Ser Asn Gln Thr Ala Phe His Gly Cys Met Glu Leu Leu Lys Val 
            500                 505                 510         


Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu Gly Arg Arg Leu Gly 
        515                 520                 525             


Phe Tyr Ala Glu Val Leu Phe Asp Thr Cys Gly Ile Thr Asp Arg Cys 
    530                 535                 540                 


Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp Asp 
545                 550                 555                 560 


Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr Lys Gly Glu Thr Cys 
                565                 570                 575     


His Thr Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser Gly 
            580                 585                 590         


Lys Thr Ser Gly Asn Phe Thr Ile Asp Pro Asp Gly Ser Gly Pro Leu 
        595                 600                 605             


Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp Thr 
    610                 615                 620                 


Val Val Arg His Asp Arg Leu Trp Thr Thr Arg Val Thr Gly Ser Ser 
625                 630                 635                 640 


Met Glu Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser Trp 
                645                 650                 655     


Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln Trp 
            660                 665                 670         


Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Thr Ala Gly Gly 
        675                 680                 685             


Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu Glu Gln His Phe Tyr 
    690                 695                 700                 


Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys Ala Cys Gly Leu Asp 
705                 710                 715                 720 


Arg Ser Cys Val Asp Pro Ala Leu Tyr Cys Asn Cys Asp Ala Asp Gln 
                725                 730                 735     


Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr Phe Val Asp His Leu 
            740                 745                 750         


Pro Val Thr Gln Val Val Ile Gly Asp Thr Asn Arg Ser Thr Ser Glu 
        755                 760                 765             


Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr Gly Asp Arg Asn Ser 
    770                 775                 780                 


Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala Leu Arg Phe Pro Pro 
785                 790                 795                 800 


Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe Tyr Phe Arg Thr Ser 
                805                 810                 815     


Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly Gly Pro Tyr Cys Gln 
            820                 825                 830         


Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn Thr Ser Arg Asp Val 
        835                 840                 845             


Val Phe Ala Phe Asp Val Gly Asn Gly Asp Glu Asn Leu Thr Val His 
    850                 855                 860                 


Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp His Leu Val Arg Ala 
865                 870                 875                 880 


Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val Asp His Arg Pro Trp 
                885                 890                 895     


Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile Trp Met Glu Tyr Asp 
            900                 905                 910         


Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys Arg Arg Pro Phe Val 
        915                 920                 925             


Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val Thr Leu Asn Leu Glu 
    930                 935                 940                 


Gly Arg Ala Asn Ala Ser Glu Gly Thr Ser Pro Asn Cys Thr Gly His 
945                 950                 955                 960 


Cys Ala His Pro Arg Leu Pro Cys Phe His Gly Gly Arg Cys Val Glu 
                965                 970                 975     


Arg Tyr Ser Tyr Tyr Thr Cys Asp Cys Asp Leu Thr Ala Phe Asp Gly 
            980                 985                 990         


Pro Tyr Cys Asn His Asp Ile Gly  Gly Phe Phe Glu Pro  Gly Thr Trp 
        995                 1000                 1005             


Met Arg  Tyr Asn Leu Gln Ser  Ala Leu Arg Ser Ala  Ala Arg Glu 
    1010                 1015                 1020             


Phe Ser  His Met Leu Ser Arg  Pro Val Pro Gly Tyr  Glu Pro Gly 
    1025                 1030                 1035             


Tyr Ile  Pro Gly Tyr Asp Thr  Pro Gly Tyr Val Pro  Gly Tyr His 
    1040                 1045                 1050             


Gly Pro  Gly Tyr Arg Leu Pro  Asp Tyr Pro Arg Pro  Gly Arg Pro 
    1055                 1060                 1065             


Val Pro  Gly Tyr Arg Gly Pro  Val Tyr Asn Val Thr  Gly Glu Glu 
    1070                 1075                 1080             


Val Ser  Phe Ser Phe Ser Thr  Ser Ser Ala Pro Ala  Val Leu Leu 
    1085                 1090                 1095             


Tyr Val  Ser Ser Phe Val Arg  Asp Tyr Met Ala Val  Leu Ile Lys 
    1100                 1105                 1110             


Asp Asp  Gly Thr Leu Gln Leu  Arg Tyr Gln Leu Gly  Thr Ser Pro 
    1115                 1120                 1125             


Tyr Val  Tyr Gln Leu Thr Thr  Arg Pro Val Thr Asp  Gly Gln Pro 
    1130                 1135                 1140             


His Ser  Ile Asn Ile Thr Arg  Val Tyr Arg Asn Leu  Phe Ile Gln 
    1145                 1150                 1155             


Val Asp  Tyr Phe Pro Leu Thr  Glu Gln Lys Phe Ser  Leu Leu Val 
    1160                 1165                 1170             


Asp Ser  Gln Leu Asp Ser Pro  Lys Ala Leu Tyr Leu  Gly Arg Val 
    1175                 1180                 1185             


Met Glu  Thr Gly Val Ile Asp  Pro Glu Ile Gln Arg  Tyr Asn Thr 
    1190                 1195                 1200             


Pro Gly  Phe Ser Gly Cys Leu  Ser Gly Val Arg Phe  Asn Asn Val 
    1205                 1210                 1215             


Ala Pro  Leu Lys Thr His Phe  Arg Thr Pro Arg Pro  Met Thr Ala 
    1220                 1225                 1230             


Glu Leu  Ala Glu Ala Leu Arg  Val Gln Gly Glu Leu  Ser Glu Ser 
    1235                 1240                 1245             


Asn Cys  Gly Ala Met Pro Arg  Leu Val Ser Glu Val  Pro Pro Glu 
    1250                 1255                 1260             


Leu Asp  Pro Trp Tyr Leu Pro  Pro Asp Phe Pro Tyr  Tyr His Asp 
    1265                 1270                 1275             


Glu Gly  Trp Val Ala Ile Leu  Leu Gly Phe Leu Val  Ala Phe Leu 
    1280                 1285                 1290             


Leu Leu  Gly Leu Val Gly Met  Leu Val Leu Phe Tyr  Leu Gln Asn 
    1295                 1300                 1305             


His Arg  Tyr Lys Gly Ser Tyr  His Thr Asn Glu Pro  Lys Ala Ala 
    1310                 1315                 1320             


His Glu  Tyr His Pro Gly Ser  Lys Pro Pro Leu Pro  Thr Ser Gly 
    1325                 1330                 1335             


Pro Ala  Gln Val Pro Thr Pro  Thr Ala Ala Pro Asn  Gln Ala Pro 
    1340                 1345                 1350             


Ala Ser  Ala Pro Ala Pro Ala  Pro Thr Pro Ala Pro  Ala Pro Gly 
    1355                 1360                 1365             


Pro Arg  Asp Gln Asn Leu Pro  Gln Ile Leu Glu Glu  Ser Arg Ser 
    1370                 1375                 1380             


Glu 
    


<210>  3514
<211>  4640
<212>  DNA
<213>  Homosapiens

<400>  3514
cccgcggctc gggatggagg ctggacacct gttctgctgt tgtgtcctgc cattctcctg     60

aagaacagag gcacactgta aaacccaaca cttccccttg cattctataa gattacagca    120

agatggaaat accaaatccc cctacctcca aatgtatcac ttactggaaa agaaaagtga    180

aatctgaata catgcgactt cgacaactta aacggcttca ggcaaatatg ggtgcaaagg    240

ctttgtatgt ggcaaatttt gcaaaggttc aagaaaaaac ccagatcctc aatgaagaat    300

ggaagaagct tcgtgtccaa cctgttcagt caatgaagcc tgtgagtgga cacccttttc    360

tcaaaaagtg taccatagag agcattttcc cgggatttgc aagccaacat atgttaatga    420

ggtcactgaa cacagttgca ttggttccca tcatgtattc ctggtcccct ctccaacaga    480

actttatggt agaagatgag acggttttgt gcaatattcc ctacatggga gatgaagtga    540

aagaagaaga tgagactttt attgaggagc tgatcaataa ctatgatggg aaagtccatg    600

gtgaagaaga gatgatccct ggatccgttc tgattagtga tgctgttttt ctggagttgg    660

tcgatgccct gaatcagtac tcagatgagg aggaggaagg gcacaatgac acctcagatg    720

gaaagcagga tgacagcaaa gaagatctgc cagtaacaag aaagagaaag cgacatgcta    780

ttgaaggcaa caaaaagagt tccaagaaac agttcccaaa tgacatgatc ttcagtgcaa    840

ttgcctcaat gttccctgag aatggtgtcc cagatgacat gaaggagagg tatcgagaac    900

taacagagat gtcagacccc aatgcacttc cccctcagtg cacacccaac atcgatggcc    960

ccaatgccaa gtctgtgcag cgggagcaat ctctgcactc cttccacaca cttttttgcc   1020

ggcgctgctt taaatacgac tgcttccttc acccttttca tgccacccct aatgtatata   1080

aacgcaagaa taaagaaatc aagattgaac cagaaccatg tggcacagac tgcttccttt   1140

tgctggaagg agcaaaggag tatgccatgc tccacaaccc ccgctccaag tgctctggtc   1200

gtcgccggag aaggcaccac atagtcagtg cttcctgctc caatgcctca gcctctgctg   1260

tggctgagac taaagaagga gacagtgaca gggacacagg caatgactgg gcctccagtt   1320

cttcagaggc taactctcgc tgtcagactc ccacaaaaca gaaggctagt ccagccccac   1380

ctcaactctg cgtagtggaa gcaccctcgg agcctgtgga atggactggg gctgaagaat   1440

ctctttttcg agtcttccat ggcacctact tcaacaactt ctgttcaata gccaggcttc   1500

tggggaccaa gacgtgcaag caggtctttc agtttgcagt caaagaatca cttatcctga   1560

agctgccaac agatgagctc atgaacccct cacagaagaa gaaaagaaag cacagattgt   1620

gggctgcaca ctgcaggaag attcagctga agaaagataa ctcttccaca caagtgtaca   1680

actaccaacc ctgcgaccac ccagaccgcc cctgtgacag cacctgcccc tgcatcatga   1740

ctcagaattt ctgtgagaag ttctgccagt gcaacccaga ctgtcagaat cgtttccctg   1800

gctgtcgctg taagacccag tgcaatacca agcaatgtcc ttgctatctg gcagtgcgag   1860

aatgtgaccc tgacctgtgt ctcacctgtg gggcctcaga gcactgggac tgcaaggtgg   1920

tttcctgtaa aaactgcagc atccagcgtg gacttaagaa gcacctgctg ctggccccct   1980

ctgatgtggc cggatggggc accttcataa aggagtctgt gcagaagaac gaattcattt   2040

ctgaatactg tggtgagctc atctctcagg atgaggctga tcgacgcgga aaggtctatg   2100

acaaatacat gtccagcttc ctcttcaacc tcaataatga ttttgtagtg gatgctactc   2160

ggaaaggaaa caaaattcga tttgcaaatc attcagtgaa tcccaactgt tatgccaaag   2220

tggtcatggt gaatggagac catcggattg ggatctttgc caagagggca attcaagctg   2280

gcgaagagct cttctttgat tacaggtaca gccaagctga tgctctcaag tacgtgggga   2340

tcgagaggga gaccgacgtc ctttagccct cccaggcccc aacggcagca cttatggtag   2400

cggcactgtc ttggctttcg tgctcacacc actgctgctc gagtctcctg cactgtgtct   2460

cccacactga gaaacccccc aacccactcc ctctgtagtg aggcctctgc catgtccaga   2520

gggcacaaaa ctgtctcaat gagaggggag acagaggcag ctagggcttg gtctcccagg   2580

acagagagtt acagaaatgg gagactgttt ctctggcctc agaagaagcg agcacaggct   2640

ggggtggatg acttatgcgt gatttcgtgt cggctcccca ggctgtggcc tcaggaatca   2700

acttaggcag ttcccaacaa gcgctagcct gtaattgtag ctttccacat caagagtcct   2760

tatgttattg ggatgcaggc aaacctctgt ggtcctaaga cctggagagg acaggctaag   2820

tgaagtgtgg tccctggagc ctacaagtgg tctgggttag aggcgagcct ggcaggcagc   2880

acagactgaa ctcagaggta gacaggtcac cttactacct cctccctcgt ggcagggctc   2940

aaactgaaag agtgtgggtt ctaagtacag gcattcaagg ctgggggaag gaaagctacg   3000

ccatccttcc ttagccagag agggagaacc agccagatga tagtagttaa actgctaagc   3060

ttgggcccag gaggctttga gaaagccttc tctgtgtact ctggagatag atggagaagt   3120

gttttcagat tcctgggaac agacaccagt gctccagctc ctccaaagtt ctggcttagc   3180

agctgcaggc aagcattatg ctgctattga agaagcatta ggggtatgcc tggcaggtgt   3240

gagcatcctg gctcgctgga tttgtgggtg ttttcaggcc ttccattccc catagaggca   3300

aggcccaatg gccagtgttg cttatcgctt cagggtaggt gggcacaggc ttggactaga   3360

gaggagaaag attggtgtaa tctgctttcc tgtctgtagt gcctgctgtt tggaaagggt   3420

gagttagaat atgttccaag gttggtgagg ggctaaattg cacgcgttta ggctggcacc   3480

ccgtgtgcag ggcacactgg cagagggtat ctgaagtggg agaagaagca ggtagaccac   3540

ctgtcccagg ctgtggtgcc accctctctg gcattcatgc agagcaaagc actttaacca   3600

tttcttttaa aaggtctata gattggggta gagtttggcc taaggtctct agggtccctg   3660

cctaaatccc actcctgagg gagggggaag aagagagggt gggagattct cctccagtcc   3720

tgtctcatct cctgggagag gcagacgagt gagtttcaca cagaagaatt tcatgtgaat   3780

ggggccagca agagctgccc tgtgtccatg gtgggtgtgc cgggctggct gggaacaagg   3840

agcagtatgt tgagtagaaa gggtgtgggc gggtatagat tggcctggga gtgttacagt   3900

agggagcagg cttctccctt ctttctggga ctcagagccc cgcttcttcc cactccactt   3960

gttgtcccat gaaggaagaa gtggggttcc tcctgaccca gctgcctctt acggtttggt   4020

atgggacatg cacacacact cacatgctct cactcaccac actggagggc acacatgtac   4080

cccgcaccca gcaactcctg acagaaagct cctcccaccc aaatgggcca ggccccagca   4140

tgatcctgaa atctgcatcc gccgtggttt gtattcattg tgcatatcag ggataccctc   4200

aagctggact gtgggttcca aattactcat agaggagaaa accagagaaa gatgaagagg   4260

aggagttagg tctatttgaa atgccagggg ctcgctgtga ggaataggtg aaaaaaaaac   4320

ttttcaccag cctttgagag actagactga ccccaccctt ccttcagtga gcagaatcac   4380

tgtggtcagt ctcctgtccc agcttcagtt catgaatact cctgttcctc cagtttccca   4440

tcctttgtcc ctgctgtccc ccacttttaa agatgggtct caacccctcc ccaccacgtc   4500

atgatggatg gggcaaggtg gtggggacta ggggagcctg gtatacatgc ggcttcattg   4560

ccaataaatt tcatgcactt taaagtcctg tggcttgtga cctcttaata aagtgttaga   4620

atccaaaaaa aaaaaaaaaa                                               4640


<210>  3515
<211>  747
<212>  PRT
<213>  Homosapiens

<400>  3515

Met Glu Ile Pro Asn Pro Pro Thr Ser Lys Cys Ile Thr Tyr Trp Lys 
1               5                   10                  15      


Arg Lys Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Leu 
            20                  25                  30          


Gln Ala Asn Met Gly Ala Lys Ala Leu Tyr Val Ala Asn Phe Ala Lys 
        35                  40                  45              


Val Gln Glu Lys Thr Gln Ile Leu Asn Glu Glu Trp Lys Lys Leu Arg 
    50                  55                  60                  


Val Gln Pro Val Gln Ser Met Lys Pro Val Ser Gly His Pro Phe Leu 
65                  70                  75                  80  


Lys Lys Cys Thr Ile Glu Ser Ile Phe Pro Gly Phe Ala Ser Gln His 
                85                  90                  95      


Met Leu Met Arg Ser Leu Asn Thr Val Ala Leu Val Pro Ile Met Tyr 
            100                 105                 110         


Ser Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val 
        115                 120                 125             


Leu Cys Asn Ile Pro Tyr Met Gly Asp Glu Val Lys Glu Glu Asp Glu 
    130                 135                 140                 


Thr Phe Ile Glu Glu Leu Ile Asn Asn Tyr Asp Gly Lys Val His Gly 
145                 150                 155                 160 


Glu Glu Glu Met Ile Pro Gly Ser Val Leu Ile Ser Asp Ala Val Phe 
                165                 170                 175     


Leu Glu Leu Val Asp Ala Leu Asn Gln Tyr Ser Asp Glu Glu Glu Glu 
            180                 185                 190         


Gly His Asn Asp Thr Ser Asp Gly Lys Gln Asp Asp Ser Lys Glu Asp 
        195                 200                 205             


Leu Pro Val Thr Arg Lys Arg Lys Arg His Ala Ile Glu Gly Asn Lys 
    210                 215                 220                 


Lys Ser Ser Lys Lys Gln Phe Pro Asn Asp Met Ile Phe Ser Ala Ile 
225                 230                 235                 240 


Ala Ser Met Phe Pro Glu Asn Gly Val Pro Asp Asp Met Lys Glu Arg 
                245                 250                 255     


Tyr Arg Glu Leu Thr Glu Met Ser Asp Pro Asn Ala Leu Pro Pro Gln 
            260                 265                 270         


Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val Gln Arg Glu 
        275                 280                 285             


Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg Cys Phe Lys 
    290                 295                 300                 


Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn Val Tyr Lys 
305                 310                 315                 320 


Arg Lys Asn Lys Glu Ile Lys Ile Glu Pro Glu Pro Cys Gly Thr Asp 
                325                 330                 335     


Cys Phe Leu Leu Leu Glu Gly Ala Lys Glu Tyr Ala Met Leu His Asn 
            340                 345                 350         


Pro Arg Ser Lys Cys Ser Gly Arg Arg Arg Arg Arg His His Ile Val 
        355                 360                 365             


Ser Ala Ser Cys Ser Asn Ala Ser Ala Ser Ala Val Ala Glu Thr Lys 
    370                 375                 380                 


Glu Gly Asp Ser Asp Arg Asp Thr Gly Asn Asp Trp Ala Ser Ser Ser 
385                 390                 395                 400 


Ser Glu Ala Asn Ser Arg Cys Gln Thr Pro Thr Lys Gln Lys Ala Ser 
                405                 410                 415     


Pro Ala Pro Pro Gln Leu Cys Val Val Glu Ala Pro Ser Glu Pro Val 
            420                 425                 430         


Glu Trp Thr Gly Ala Glu Glu Ser Leu Phe Arg Val Phe His Gly Thr 
        435                 440                 445             


Tyr Phe Asn Asn Phe Cys Ser Ile Ala Arg Leu Leu Gly Thr Lys Thr 
    450                 455                 460                 


Cys Lys Gln Val Phe Gln Phe Ala Val Lys Glu Ser Leu Ile Leu Lys 
465                 470                 475                 480 


Leu Pro Thr Asp Glu Leu Met Asn Pro Ser Gln Lys Lys Lys Arg Lys 
                485                 490                 495     


His Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp 
            500                 505                 510         


Asn Ser Ser Thr Gln Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Asp 
        515                 520                 525             


Arg Pro Cys Asp Ser Thr Cys Pro Cys Ile Met Thr Gln Asn Phe Cys 
    530                 535                 540                 


Glu Lys Phe Cys Gln Cys Asn Pro Asp Cys Gln Asn Arg Phe Pro Gly 
545                 550                 555                 560 


Cys Arg Cys Lys Thr Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu 
                565                 570                 575     


Ala Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ser 
            580                 585                 590         


Glu His Trp Asp Cys Lys Val Val Ser Cys Lys Asn Cys Ser Ile Gln 
        595                 600                 605             


Arg Gly Leu Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly 
    610                 615                 620                 


Trp Gly Thr Phe Ile Lys Glu Ser Val Gln Lys Asn Glu Phe Ile Ser 
625                 630                 635                 640 


Glu Tyr Cys Gly Glu Leu Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly 
                645                 650                 655     


Lys Val Tyr Asp Lys Tyr Met Ser Ser Phe Leu Phe Asn Leu Asn Asn 
            660                 665                 670         


Asp Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala 
        675                 680                 685             


Asn His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Val Met Val Asn 
    690                 695                 700                 


Gly Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Ala Gly 
705                 710                 715                 720 


Glu Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys 
                725                 730                 735     


Tyr Val Gly Ile Glu Arg Glu Thr Asp Val Leu 
            740                 745         


<210>  3516
<211>  780
<212>  DNA
<213>  Homosapiens

<400>  3516
ggatataggc gcccccacac ccgggcccgg ctaagcgccg ccgccgctcc tcgcctcctt     60

gctgcacgat ggcctcgctc cgggtggagc gcgccggcgg cccgcgtctc cctaggaccc    120

gagtcgggcg gccggcagcc gtccgcctcc tccttctgct gggcgctgtc ctgaatcccc    180

acgaggccct ggctcagcct cttcccacca caggcacacc agggtcagaa ggggggacgg    240

tgaagaacta tgagacagct gtccaatttt gctggaatca ttataaggat caaatggatc    300

ctatcgaaaa ggattggtgc gactgggcca tgattagcag gccttatagc accctgcgag    360

attgcctgga gcactttgca gagttgtttg acctgggctt ccccaatccc ttggcagaga    420

ggatcatctt tgagactcac cagatccact ttgccaactg ctccctggtg cagcccacct    480

tctctgaccc cccagaggat gtactcctgg ccatgatcat agcccccatc tgcctcatcc    540

ccttcctcat cactcttgta gtatggagga gtaaagacag tgaggcccag gcctaggggg    600

cacgagcttc tcaacaacca tgttactcca cttccccacc cccaccaggc ctccctcctc    660

ccctcctact cccttttctc actctcatcc ccaccacaga tccctggatt gctgggaatg    720

gaagccaggg ttgggcatgg cacaagttct gtaatcttca aaataaaact ttttttttga    780


<210>  3517
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  3517

Met Ala Ser Leu Arg Val Glu Arg Ala Gly Gly Pro Arg Leu Pro Arg 
1               5                   10                  15      


Thr Arg Val Gly Arg Pro Ala Ala Val Arg Leu Leu Leu Leu Leu Gly 
            20                  25                  30          


Ala Val Leu Asn Pro His Glu Ala Leu Ala Gln Pro Leu Pro Thr Thr 
        35                  40                  45              


Gly Thr Pro Gly Ser Glu Gly Gly Thr Val Lys Asn Tyr Glu Thr Ala 
    50                  55                  60                  


Val Gln Phe Cys Trp Asn His Tyr Lys Asp Gln Met Asp Pro Ile Glu 
65                  70                  75                  80  


Lys Asp Trp Cys Asp Trp Ala Met Ile Ser Arg Pro Tyr Ser Thr Leu 
                85                  90                  95      


Arg Asp Cys Leu Glu His Phe Ala Glu Leu Phe Asp Leu Gly Phe Pro 
            100                 105                 110         


Asn Pro Leu Ala Glu Arg Ile Ile Phe Glu Thr His Gln Ile His Phe 
        115                 120                 125             


Ala Asn Cys Ser Leu Val Gln Pro Thr Phe Ser Asp Pro Pro Glu Asp 
    130                 135                 140                 


Val Leu Leu Ala Met Ile Ile Ala Pro Ile Cys Leu Ile Pro Phe Leu 
145                 150                 155                 160 


Ile Thr Leu Val Val Trp Arg Ser Lys Asp Ser Glu Ala Gln Ala 
                165                 170                 175 


<210>  3518
<211>  1122
<212>  DNA
<213>  Homosapiens

<400>  3518
gtccttagcc ggtagcttcc gggtttcctg ggctactacg atggcgatga gtttcgagtg     60

gccgtggcag tatcgcttcc cacccttctt tacgttacaa ccgaatgtgg acactcggca    120

gaagcagctg gccgcctggt gctcgctggt cctgtccttc tgccgcctgc acaaacagtc    180

cagcatgacg gtgatggaag ctcaggagag cccgctcttc aacaacgtca agctacagcg    240

aaagcttcct gtggagtcga tccagattgt attagaggaa ctgaggaaga aagggaacct    300

cgagtggttg gataagagca agtccagctt cctgatcatg tggcggaggc cagaagaatg    360

ggggaaactc atctatcagt gggtttccag gagtggccag aacaactccg tctttaccct    420

gtatgaactg actaatgggg aagacacaga ggatgaggag ttccacgggc tggatgaagc    480

cactctactg cgggctctgc aggccctaca gcaggagcac aaggccgaga tcatcactgt    540

cagcgatggc cgaggcgtca agttcttcta gcagggacct gtctcccttt acttcttacc    600

tcccaccttt ccagggcttt caaaaggaga cagacccagt gtcccccaaa gactggatct    660

gtgactccac cagactcaaa aggactccag tcctgaaggc tgggacctgg ggatgggttt    720

ctcacacccc atatgtctgt cccttggata gggtgaggct gaagcaccag ggagaaaata    780

tgtgcttctt ctcgccctac ctcctttccc atcctagact gtccttgagc cagggtctgt    840

aaacctgaca ctttatatgt gttcacacat gtaagtacat acacacatgc gcctgcagca    900

catgcttctg tctcctcctc ctcccacccc tttagctgct gttgcctccc ttctcaggct    960

ggtgctggat ccttcctagg ggatggggga agccctggct gcaggcagcc ttccaggcaa   1020

tatgaagata ggaggcccac gggcctggca gtgagaggtg tggccccaca ccgatttatg   1080

atattaaaat ctcaactccc aaaaaaaaaa aaaaaaaaaa aa                      1122


<210>  3519
<211>  176
<212>  PRT
<213>  Homosapiens

<400>  3519

Met Ala Met Ser Phe Glu Trp Pro Trp Gln Tyr Arg Phe Pro Pro Phe 
1               5                   10                  15      


Phe Thr Leu Gln Pro Asn Val Asp Thr Arg Gln Lys Gln Leu Ala Ala 
            20                  25                  30          


Trp Cys Ser Leu Val Leu Ser Phe Cys Arg Leu His Lys Gln Ser Ser 
        35                  40                  45              


Met Thr Val Met Glu Ala Gln Glu Ser Pro Leu Phe Asn Asn Val Lys 
    50                  55                  60                  


Leu Gln Arg Lys Leu Pro Val Glu Ser Ile Gln Ile Val Leu Glu Glu 
65                  70                  75                  80  


Leu Arg Lys Lys Gly Asn Leu Glu Trp Leu Asp Lys Ser Lys Ser Ser 
                85                  90                  95      


Phe Leu Ile Met Trp Arg Arg Pro Glu Glu Trp Gly Lys Leu Ile Tyr 
            100                 105                 110         


Gln Trp Val Ser Arg Ser Gly Gln Asn Asn Ser Val Phe Thr Leu Tyr 
        115                 120                 125             


Glu Leu Thr Asn Gly Glu Asp Thr Glu Asp Glu Glu Phe His Gly Leu 
    130                 135                 140                 


Asp Glu Ala Thr Leu Leu Arg Ala Leu Gln Ala Leu Gln Gln Glu His 
145                 150                 155                 160 


Lys Ala Glu Ile Ile Thr Val Ser Asp Gly Arg Gly Val Lys Phe Phe 
                165                 170                 175     


<210>  3520
<211>  4147
<212>  DNA
<213>  Homosapiens

<400>  3520
ttcggcgccc tgctcttcct catgttggca tccccggcca cggagaccac cgtcctcatg     60

tcccagactg aggccgacct ggccctgcgg cccccgcctc ctcttggcac cgcggggcag    120

ccccgcctcg ggccccctcc tcgccgagcg cgccgcttct ccgggaaggc tgagccccgg    180

ccgcgctctt ctcgtctcag ccgccgtagc tcagtcgact tggggctgct gagctcttgg    240

tccctgccag cctcacccgc tccggacccc cccgatcctc cggactccgc tggtcctggc    300

cccgcgagga gcccaccgcc tagctccaaa gaaccccccg agggcacgtg gaccgaggga    360

gcccctgtga aggctgcgga agactccgcg cgtcccgagc tcccggactc tgcagtgggc    420

ccggggtcca gggagccgct aagggtccct gaagctgtgg ccctagagcg gcggcgggag    480

caggaagaaa aggaggacat ggagacccag gctgtggcaa cgtcccccga tggccgatac    540

ctcaagtttg acatcgagat tggacgtggc tccttcaaga cggtgtatcg agggctagac    600

accgacacca cagtggaggt ggcctggtgt gagctgcaga ctcggaaact gtctagagct    660

gagcggcagc gcttctcaga ggaggtggag atgctcaagg ggctgcagca ccccaacatc    720

gtccgcttct atgattcgtg gaagtcggtg ctgaggggcc aggtttgcat cgtgctggtc    780

accgaactca tgacctcggg cacgctcaag acgtacctga ggcggttccg ggagatgaag    840

ccgcgggtcc ttcagcgctg gagccgccaa atcctgcggg gacttcattt cctacactcc    900

cgggttcctc ccatcctgca ccgggatctc aagtgcgaca atgtctttat cacgggacct    960

actggctctg tcaaaatcgg ggacctgggc ctggccacgc tcaagcgcgc ctcctttgcc   1020

aagagtgtca tcgggacccc ggaattcatg gcccccgaga tgtacgagga aaagtacgat   1080

gaggccgtgg acgtgtacgc gttcggcatg tgcatgctgg agatggccac ctctgagtac   1140

ccgtactccg agtgccagaa tgccgcgcaa atctaccgca aggtcacttc gggcagaaag   1200

ccgaacagct tccacaaggt gaagataccc gaggtgaagg agatcattga aggctgcatc   1260

cgcacggata agaacgagag gttcaccatc caggacctcc tggcccacgc cttcttccgc   1320

gaggagcgcg gtgtgcacgt ggaactagcg gaggaggacg acggcgagaa gccgggcctc   1380

aagctctggc tgcgcatgga ggacgcgcgg cgcggggggc gcccacggga caaccaggcc   1440

atcgagttcc tgttccagct gggccgggac gcggccgagg aggtggcaca ggagatggtg   1500

gctctgggct tggtctgtga agccgattac cagccagtgg cccgtgcagt acgtgaacgg   1560

gttgctgcca tccagcgaaa gcgtgagaag ctgcgtaaag caagggaatt ggaggcactc   1620

ccaccagagc caggacctcc accagcaact gtgcccatgg cccccggtcc ccccagtgtc   1680

ttcccccctg agcctgagga gccagaggca gaccagcacc agcccttcct tttccgccac   1740

gccagctact catctaccac ttcggattgc gagactgatg gctacctcag ctcctccggc   1800

ttcctggatg cctcagaccc tgcccttcag ccccctgggg gggtgccatc cagcctggct   1860

gagtcccatc tctgcctgcc ctcggctttt gccctatcca ttccacgttc tggccctgga   1920

agtgactttt cccccgggga cagctatgcc tcagatgcag cttcaggcct tagcgatgtg   1980

ggagaaggga tgggacaaat gaggagaccc ccagggagga atctccggcg cagaccccga   2040

tcccggctgc gggtcactag tgtctcagac cagaatgaca gagtggttga gtgccagcta   2100

cagacccata acagcaagat ggtgaccttc cgatttgatc tggatgggga cagcccggaa   2160

gagattgcag ctgccatggt atataacgag ttcattctgc cttcggagcg agatggattt   2220

ctcagacgga ttcgggagat tatccagcga gtggagaccc tgttgaagag agacactggc   2280

cccatggagg ctgctgaaga caccctaagc ccccaggagg agccagcacc attacctgcc   2340

ctgcccgtcc ccctcccaga cccatccaat gaagagctcc agagcagcac ctccctggag   2400

cacaggagct ggacagcctt ctccacctcc tcatcttctc ctggaactcc tttgtctcct   2460

ggaaacccat tttcccctgg aacccccatt tccccaggtc ccatcttccc catcacttct   2520

cccccatgtc atcccagccc ctccccattc tcccccattt cttcccaggt ctcctcaaat   2580

ccctctccac accccaccag ctctccactt ccattctcct ccagcacacc cgagtttccg   2640

gtcccactct ctcagtgtcc ctggagttct ctccccacga cttctccacc tacgttctct   2700

cccacttgtt ctcaggtcac tcttagttcc cctttctttc ctccgtgccc ctccacttct   2760

tccttcccct ccaccacagc agcccctctc ctttctctgg ctagtgcctt ctcactggct   2820

gtgatgactg tggcccagtc cctgctgtcc ccctcacctg ggctcctttc ccagtctcct   2880

ccagcccctc ctagtcccct ccctagcctg ccccttcccc ctcccgttgc tcctggtggc   2940

caggaaagcc cttcacccca cacagctgag gtggagagtg aggcctcacc acctcctgct   3000

cggcccctcc caggggaagc caggctggcg cccatctctg aagagggaaa gccgcagctt   3060

gttgggcgtt tccaagtgac ttcatccaag gaaccggctg agcctcttcc cttgcagcca   3120

acatccccca ctctctctgg ttctccaaaa ccttcaaccc ctcagctcac ttcagagagc   3180

tcagatacag aggacagtgc tggaggcggg ccagagacca gggaagctct ggctgagagc   3240

gaccgtgcag ctgagggtct gggggctgga gttgaggagg aaggagatga tgggaaggaa   3300

ccccaagttg ggggcagccc ccaacccctg agccatccca gcccagtgtg gatgaactac   3360

tcctacagca gcctgtgttt gagcagcgag gagtcagaaa gcagtgggga agatgaggag   3420

ttctgggctg agctgcagag tcttcggcag aagcacttgt cagaggtgga aacactacag   3480

acactacaga aaaaagaaat tgaagatttg tacagccggc tggggaagca gcccccaccg   3540

ggtattgtgg ccccagctgc tatgctgtcc agccgccagc gccgcctctc caagggcagc   3600

ttccccacct cccgccgcaa cagcctacag cgctctgagc ccccaggccc tggcatcatg   3660

cgaaggaact ctctgagtgg cagcagcacc ggctcccagg agcagcgggc aagcaagggg   3720

gtgacattcg ccggggatgt tggcaggatg tgaattcaga acagaagcca tgtatctccc   3780

ccacaccagg gcccaccatg gagcttgtgt tctcagaatc tgatgctttc tgatcaacaa   3840

aactgagcaa ggaagatccc aacactgaag gggtagaagg ccaggggggc atggagagtg   3900

cagctccatt atagtgaaga gccaaacata tgtgaactgt ttgctgtgtg gaggtgttag   3960

ttctgctgcc taccatcttc atctctagca cctcccctgc caagagtcaa ccactaagca   4020

atcccaccca agcctggatg cttctagagg ggcccactcc cagctgggag agtgtagggg   4080

atatgctcac accacattag cagcaaccaa taaaaatgct ggaaacaaga aaaaaaaaaa   4140

aaaaaaa                                                             4147


<210>  3521
<211>  1243
<212>  PRT
<213>  Homosapiens

<400>  3521

Met Leu Ala Ser Pro Ala Thr Glu Thr Thr Val Leu Met Ser Gln Thr 
1               5                   10                  15      


Glu Ala Asp Leu Ala Leu Arg Pro Pro Pro Pro Leu Gly Thr Ala Gly 
            20                  25                  30          


Gln Pro Arg Leu Gly Pro Pro Pro Arg Arg Ala Arg Arg Phe Ser Gly 
        35                  40                  45              


Lys Ala Glu Pro Arg Pro Arg Ser Ser Arg Leu Ser Arg Arg Ser Ser 
    50                  55                  60                  


Val Asp Leu Gly Leu Leu Ser Ser Trp Ser Leu Pro Ala Ser Pro Ala 
65                  70                  75                  80  


Pro Asp Pro Pro Asp Pro Pro Asp Ser Ala Gly Pro Gly Pro Ala Arg 
                85                  90                  95      


Ser Pro Pro Pro Ser Ser Lys Glu Pro Pro Glu Gly Thr Trp Thr Glu 
            100                 105                 110         


Gly Ala Pro Val Lys Ala Ala Glu Asp Ser Ala Arg Pro Glu Leu Pro 
        115                 120                 125             


Asp Ser Ala Val Gly Pro Gly Ser Arg Glu Pro Leu Arg Val Pro Glu 
    130                 135                 140                 


Ala Val Ala Leu Glu Arg Arg Arg Glu Gln Glu Glu Lys Glu Asp Met 
145                 150                 155                 160 


Glu Thr Gln Ala Val Ala Thr Ser Pro Asp Gly Arg Tyr Leu Lys Phe 
                165                 170                 175     


Asp Ile Glu Ile Gly Arg Gly Ser Phe Lys Thr Val Tyr Arg Gly Leu 
            180                 185                 190         


Asp Thr Asp Thr Thr Val Glu Val Ala Trp Cys Glu Leu Gln Thr Arg 
        195                 200                 205             


Lys Leu Ser Arg Ala Glu Arg Gln Arg Phe Ser Glu Glu Val Glu Met 
    210                 215                 220                 


Leu Lys Gly Leu Gln His Pro Asn Ile Val Arg Phe Tyr Asp Ser Trp 
225                 230                 235                 240 


Lys Ser Val Leu Arg Gly Gln Val Cys Ile Val Leu Val Thr Glu Leu 
                245                 250                 255     


Met Thr Ser Gly Thr Leu Lys Thr Tyr Leu Arg Arg Phe Arg Glu Met 
            260                 265                 270         


Lys Pro Arg Val Leu Gln Arg Trp Ser Arg Gln Ile Leu Arg Gly Leu 
        275                 280                 285             


His Phe Leu His Ser Arg Val Pro Pro Ile Leu His Arg Asp Leu Lys 
    290                 295                 300                 


Cys Asp Asn Val Phe Ile Thr Gly Pro Thr Gly Ser Val Lys Ile Gly 
305                 310                 315                 320 


Asp Leu Gly Leu Ala Thr Leu Lys Arg Ala Ser Phe Ala Lys Ser Val 
                325                 330                 335     


Ile Gly Thr Pro Glu Phe Met Ala Pro Glu Met Tyr Glu Glu Lys Tyr 
            340                 345                 350         


Asp Glu Ala Val Asp Val Tyr Ala Phe Gly Met Cys Met Leu Glu Met 
        355                 360                 365             


Ala Thr Ser Glu Tyr Pro Tyr Ser Glu Cys Gln Asn Ala Ala Gln Ile 
    370                 375                 380                 


Tyr Arg Lys Val Thr Ser Gly Arg Lys Pro Asn Ser Phe His Lys Val 
385                 390                 395                 400 


Lys Ile Pro Glu Val Lys Glu Ile Ile Glu Gly Cys Ile Arg Thr Asp 
                405                 410                 415     


Lys Asn Glu Arg Phe Thr Ile Gln Asp Leu Leu Ala His Ala Phe Phe 
            420                 425                 430         


Arg Glu Glu Arg Gly Val His Val Glu Leu Ala Glu Glu Asp Asp Gly 
        435                 440                 445             


Glu Lys Pro Gly Leu Lys Leu Trp Leu Arg Met Glu Asp Ala Arg Arg 
    450                 455                 460                 


Gly Gly Arg Pro Arg Asp Asn Gln Ala Ile Glu Phe Leu Phe Gln Leu 
465                 470                 475                 480 


Gly Arg Asp Ala Ala Glu Glu Val Ala Gln Glu Met Val Ala Leu Gly 
                485                 490                 495     


Leu Val Cys Glu Ala Asp Tyr Gln Pro Val Ala Arg Ala Val Arg Glu 
            500                 505                 510         


Arg Val Ala Ala Ile Gln Arg Lys Arg Glu Lys Leu Arg Lys Ala Arg 
        515                 520                 525             


Glu Leu Glu Ala Leu Pro Pro Glu Pro Gly Pro Pro Pro Ala Thr Val 
    530                 535                 540                 


Pro Met Ala Pro Gly Pro Pro Ser Val Phe Pro Pro Glu Pro Glu Glu 
545                 550                 555                 560 


Pro Glu Ala Asp Gln His Gln Pro Phe Leu Phe Arg His Ala Ser Tyr 
                565                 570                 575     


Ser Ser Thr Thr Ser Asp Cys Glu Thr Asp Gly Tyr Leu Ser Ser Ser 
            580                 585                 590         


Gly Phe Leu Asp Ala Ser Asp Pro Ala Leu Gln Pro Pro Gly Gly Val 
        595                 600                 605             


Pro Ser Ser Leu Ala Glu Ser His Leu Cys Leu Pro Ser Ala Phe Ala 
    610                 615                 620                 


Leu Ser Ile Pro Arg Ser Gly Pro Gly Ser Asp Phe Ser Pro Gly Asp 
625                 630                 635                 640 


Ser Tyr Ala Ser Asp Ala Ala Ser Gly Leu Ser Asp Val Gly Glu Gly 
                645                 650                 655     


Met Gly Gln Met Arg Arg Pro Pro Gly Arg Asn Leu Arg Arg Arg Pro 
            660                 665                 670         


Arg Ser Arg Leu Arg Val Thr Ser Val Ser Asp Gln Asn Asp Arg Val 
        675                 680                 685             


Val Glu Cys Gln Leu Gln Thr His Asn Ser Lys Met Val Thr Phe Arg 
    690                 695                 700                 


Phe Asp Leu Asp Gly Asp Ser Pro Glu Glu Ile Ala Ala Ala Met Val 
705                 710                 715                 720 


Tyr Asn Glu Phe Ile Leu Pro Ser Glu Arg Asp Gly Phe Leu Arg Arg 
                725                 730                 735     


Ile Arg Glu Ile Ile Gln Arg Val Glu Thr Leu Leu Lys Arg Asp Thr 
            740                 745                 750         


Gly Pro Met Glu Ala Ala Glu Asp Thr Leu Ser Pro Gln Glu Glu Pro 
        755                 760                 765             


Ala Pro Leu Pro Ala Leu Pro Val Pro Leu Pro Asp Pro Ser Asn Glu 
    770                 775                 780                 


Glu Leu Gln Ser Ser Thr Ser Leu Glu His Arg Ser Trp Thr Ala Phe 
785                 790                 795                 800 


Ser Thr Ser Ser Ser Ser Pro Gly Thr Pro Leu Ser Pro Gly Asn Pro 
                805                 810                 815     


Phe Ser Pro Gly Thr Pro Ile Ser Pro Gly Pro Ile Phe Pro Ile Thr 
            820                 825                 830         


Ser Pro Pro Cys His Pro Ser Pro Ser Pro Phe Ser Pro Ile Ser Ser 
        835                 840                 845             


Gln Val Ser Ser Asn Pro Ser Pro His Pro Thr Ser Ser Pro Leu Pro 
    850                 855                 860                 


Phe Ser Ser Ser Thr Pro Glu Phe Pro Val Pro Leu Ser Gln Cys Pro 
865                 870                 875                 880 


Trp Ser Ser Leu Pro Thr Thr Ser Pro Pro Thr Phe Ser Pro Thr Cys 
                885                 890                 895     


Ser Gln Val Thr Leu Ser Ser Pro Phe Phe Pro Pro Cys Pro Ser Thr 
            900                 905                 910         


Ser Ser Phe Pro Ser Thr Thr Ala Ala Pro Leu Leu Ser Leu Ala Ser 
        915                 920                 925             


Ala Phe Ser Leu Ala Val Met Thr Val Ala Gln Ser Leu Leu Ser Pro 
    930                 935                 940                 


Ser Pro Gly Leu Leu Ser Gln Ser Pro Pro Ala Pro Pro Ser Pro Leu 
945                 950                 955                 960 


Pro Ser Leu Pro Leu Pro Pro Pro Val Ala Pro Gly Gly Gln Glu Ser 
                965                 970                 975     


Pro Ser Pro His Thr Ala Glu Val Glu Ser Glu Ala Ser Pro Pro Pro 
            980                 985                 990         


Ala Arg Pro Leu Pro Gly Glu Ala  Arg Leu Ala Pro Ile  Ser Glu Glu 
        995                 1000                 1005             


Gly Lys  Pro Gln Leu Val Gly  Arg Phe Gln Val Thr  Ser Ser Lys 
    1010                 1015                 1020             


Glu Pro  Ala Glu Pro Leu Pro  Leu Gln Pro Thr Ser  Pro Thr Leu 
    1025                 1030                 1035             


Ser Gly  Ser Pro Lys Pro Ser  Thr Pro Gln Leu Thr  Ser Glu Ser 
    1040                 1045                 1050             


Ser Asp  Thr Glu Asp Ser Ala  Gly Gly Gly Pro Glu  Thr Arg Glu 
    1055                 1060                 1065             


Ala Leu  Ala Glu Ser Asp Arg  Ala Ala Glu Gly Leu  Gly Ala Gly 
    1070                 1075                 1080             


Val Glu  Glu Glu Gly Asp Asp  Gly Lys Glu Pro Gln  Val Gly Gly 
    1085                 1090                 1095             


Ser Pro  Gln Pro Leu Ser His  Pro Ser Pro Val Trp  Met Asn Tyr 
    1100                 1105                 1110             


Ser Tyr  Ser Ser Leu Cys Leu  Ser Ser Glu Glu Ser  Glu Ser Ser 
    1115                 1120                 1125             


Gly Glu  Asp Glu Glu Phe Trp  Ala Glu Leu Gln Ser  Leu Arg Gln 
    1130                 1135                 1140             


Lys His  Leu Ser Glu Val Glu  Thr Leu Gln Thr Leu  Gln Lys Lys 
    1145                 1150                 1155             


Glu Ile  Glu Asp Leu Tyr Ser  Arg Leu Gly Lys Gln  Pro Pro Pro 
    1160                 1165                 1170             


Gly Ile  Val Ala Pro Ala Ala  Met Leu Ser Ser Arg  Gln Arg Arg 
    1175                 1180                 1185             


Leu Ser  Lys Gly Ser Phe Pro  Thr Ser Arg Arg Asn  Ser Leu Gln 
    1190                 1195                 1200             


Arg Ser  Glu Pro Pro Gly Pro  Gly Ile Met Arg Arg  Asn Ser Leu 
    1205                 1210                 1215             


Ser Gly  Ser Ser Thr Gly Ser  Gln Glu Gln Arg Ala  Ser Lys Gly 
    1220                 1225                 1230             


Val Thr  Phe Ala Gly Asp Val  Gly Arg Met 
    1235                 1240             


<210>  3522
<211>  772
<212>  DNA
<213>  Homosapiens

<400>  3522
gcaacatggc gtcttcggga gctggtgacc ctctggattc taagcgtgga gaggccccgt     60

tcgctcagcg tatcgacccg actcgggaga agctgacacc cgagcaactg cattccatgc    120

ggcaggcgga gcttgcccag tggcagaagg tcctaccacg gcggcgaacc cggaacatcg    180

tgaccggcct aggcatcggg gccctggtgt tggctattta tggttacacc ttctactcga    240

tttcccagga gcgtttccta gatgagctag aagacgaggc caaagctgcc cgagcccgag    300

ctctggcaag ggcgtcaggg tcctaatctg gatgggtatt gatcatgtcc aacctgctgg    360

agccccttca catggtggat gatgccccat gaccctgtag aaattgaatc ctgctcacaa    420

cattgttggc cttcttacta accttggacc gtgattgagc ccaagaaacc agggacttac    480

gcatttggcc aatgtcaaaa gaacagaact ttgcccactg cacacttgct gtgtacaatg    540

actgagccct ttcttgtagt ttgtttcctt gtttgagagg tgtgcatgcg accgtggctt    600

ttcccaaagt ttctgacttt gtggtttacc cccttcacct tccagggacg cagttgttac    660

gaggttagac gtggcagctc tgtgcagtgt ttgagcctac agtgggatac atagggtcaa    720

attgagaata ataaactgag tcattctcct ggaaaaaaaa aaaaaaaaaa aa            772


<210>  3523
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  3523

Met Ala Ser Ser Gly Ala Gly Asp Pro Leu Asp Ser Lys Arg Gly Glu 
1               5                   10                  15      


Ala Pro Phe Ala Gln Arg Ile Asp Pro Thr Arg Glu Lys Leu Thr Pro 
            20                  25                  30          


Glu Gln Leu His Ser Met Arg Gln Ala Glu Leu Ala Gln Trp Gln Lys 
        35                  40                  45              


Val Leu Pro Arg Arg Arg Thr Arg Asn Ile Val Thr Gly Leu Gly Ile 
    50                  55                  60                  


Gly Ala Leu Val Leu Ala Ile Tyr Gly Tyr Thr Phe Tyr Ser Ile Ser 
65                  70                  75                  80  


Gln Glu Arg Phe Leu Asp Glu Leu Glu Asp Glu Ala Lys Ala Ala Arg 
                85                  90                  95      


Ala Arg Ala Leu Ala Arg Ala Ser Gly Ser 
            100                 105     


<210>  3524
<211>  2241
<212>  DNA
<213>  Homosapiens

<400>  3524
aattgggttt tcctcagact tgaggcgacg acacactcat tggaagggga cgaggaatcc     60

agggtgtggc agaagactgg agaggagcta agggggtcgg tatgtggatc cagtgaaccc    120

gtccaggtgc cccaagaggc tcgtgaatat ggacggatcc atgaggccac gatcggcctc    180

cctcgttgac tttcagtttg gagttgtcgc cacagagacg attgaagacg ccctgcttca    240

cttggcccag cagaatgagc aagcagtgag ggaggcttcg gggcggctgg gccgcttcag    300

ggagccccag atcgtggagt ttgtttttct cctgtctgaa caatggtgtc tggagaaatc    360

tgtgagctac caggctgtag aaatcctaga aaggtttatg gtaaaacagg cagagaacat    420

ctgcaggcaa gccacaatcc agccaagaga taataagaga gagtctcaga attggagggc    480

tctgaaacag cagcttgtca acaagtttac tctccgtctt gtgtcatgtg ttcagctggc    540

cagcaaactt tccttccgaa acaaaataat cagcaacatt acagtcttga atttcctcca    600

ggctctaggc tatctacaca ctaaagaaga actgctggaa tcagagcttg atgttttgaa    660

gtccttgaac ttccgaatta atctgcccac tcccctggca tatgtggaga cgctcctaga    720

ggttttagga tacaatggct gtttggttcc agccatgagg ctgcatgcaa cctgcctgac    780

actgctcgac ctggtctatc ttctgcatga acccatatat gagagcctgt tgagggcttc    840

aattgagaac tccactccca gtcagctgca aggggaaaag tttacttcag tgaaggaaga    900

cttcatgctg ttggcagtag gaatcattgc agcaagtgct ttcatccaaa accatgagtg    960

ttggagccag gttgtggggc atttgcagag catcactggt attgccttgg caagcattgc   1020

tgagttctct tatgcaatcc tgactcacgg agtgggagcc aacactccgg ggagacagca   1080

gtctattcct ccccacctgg cagccagagc tctgaagact gttgcttcct ctaacacatg   1140

agggaggctg aatccaccaa atataaacag ccatccgtca ctgcactcat gcctccctct   1200

gtttactttc atactaaggg tacaaaaatt ccaagtctct tttgaactgt attttgtatg   1260

ccaatttcat gcttattttt cctttatcag agagagttaa ggtggacgag catgcccttt   1320

ttgtcatatc agcctgaaaa tgttaaaaag ctaggtggag acagattagt tgtttcattt   1380

ttgtttaaca aggtatttat acttttagct taatttcatt aagaggaaca tcaggcattg   1440

caatcagtat taatcagggg ctcaaataca gactatctgg gtgaccttga ctaagcatca   1500

aggaggtagc ctttatttcc ccttaaaatt agtttaacat ctctgttcca ttattcagat   1560

ctacacaaac aaggcttcct caacagctat ctatttttac tagagtcttt ttttaaaact   1620

aaaactaact ctaaagaagt ttcaacagaa tttccacata cctgcattca ttagaacttg   1680

attctcccag aatacaaagt actctatttt aaagaaaaac ccaacagtgc acccctgggc   1740

agttttcaga ctgcagcaaa tcttttatta caaataatta aatctctcca taatgtctca   1800

aacagtatca aacaccattt catatctcta acacagagca gagtcggcat tcagtataag   1860

aaccaagtga aaagtgttaa atttcaagca tctgatcaca tcacatggtg accaggtaaa   1920

gcttagatgt cattttccca cattatccaa ctgtgcatct caaacatatc ctcatctcag   1980

taaagacaaa agtttctatt tcatattgtt aagtgcagga agttgagaga gataaaaatc   2040

cagtgaaaac acatcaatct caattcaact cagttaaaaa aaagaaaagc aaatttaaat   2100

tagttttttt cagagaagaa agggaaagga gtccatgggg ttaagaatca aaactgacca   2160

gggctggcaa ctatagatgg catgttgtag ctctggaaag tatctgtcac atgatatttt   2220

aaaataaagt ggcttttgtg g                                             2241


<210>  3525
<211>  330
<212>  PRT
<213>  Homosapiens

<400>  3525

Met Asp Gly Ser Met Arg Pro Arg Ser Ala Ser Leu Val Asp Phe Gln 
1               5                   10                  15      


Phe Gly Val Val Ala Thr Glu Thr Ile Glu Asp Ala Leu Leu His Leu 
            20                  25                  30          


Ala Gln Gln Asn Glu Gln Ala Val Arg Glu Ala Ser Gly Arg Leu Gly 
        35                  40                  45              


Arg Phe Arg Glu Pro Gln Ile Val Glu Phe Val Phe Leu Leu Ser Glu 
    50                  55                  60                  


Gln Trp Cys Leu Glu Lys Ser Val Ser Tyr Gln Ala Val Glu Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Met Val Lys Gln Ala Glu Asn Ile Cys Arg Gln Ala Thr 
                85                  90                  95      


Ile Gln Pro Arg Asp Asn Lys Arg Glu Ser Gln Asn Trp Arg Ala Leu 
            100                 105                 110         


Lys Gln Gln Leu Val Asn Lys Phe Thr Leu Arg Leu Val Ser Cys Val 
        115                 120                 125             


Gln Leu Ala Ser Lys Leu Ser Phe Arg Asn Lys Ile Ile Ser Asn Ile 
    130                 135                 140                 


Thr Val Leu Asn Phe Leu Gln Ala Leu Gly Tyr Leu His Thr Lys Glu 
145                 150                 155                 160 


Glu Leu Leu Glu Ser Glu Leu Asp Val Leu Lys Ser Leu Asn Phe Arg 
                165                 170                 175     


Ile Asn Leu Pro Thr Pro Leu Ala Tyr Val Glu Thr Leu Leu Glu Val 
            180                 185                 190         


Leu Gly Tyr Asn Gly Cys Leu Val Pro Ala Met Arg Leu His Ala Thr 
        195                 200                 205             


Cys Leu Thr Leu Leu Asp Leu Val Tyr Leu Leu His Glu Pro Ile Tyr 
    210                 215                 220                 


Glu Ser Leu Leu Arg Ala Ser Ile Glu Asn Ser Thr Pro Ser Gln Leu 
225                 230                 235                 240 


Gln Gly Glu Lys Phe Thr Ser Val Lys Glu Asp Phe Met Leu Leu Ala 
                245                 250                 255     


Val Gly Ile Ile Ala Ala Ser Ala Phe Ile Gln Asn His Glu Cys Trp 
            260                 265                 270         


Ser Gln Val Val Gly His Leu Gln Ser Ile Thr Gly Ile Ala Leu Ala 
        275                 280                 285             


Ser Ile Ala Glu Phe Ser Tyr Ala Ile Leu Thr His Gly Val Gly Ala 
    290                 295                 300                 


Asn Thr Pro Gly Arg Gln Gln Ser Ile Pro Pro His Leu Ala Ala Arg 
305                 310                 315                 320 


Ala Leu Lys Thr Val Ala Ser Ser Asn Thr 
                325                 330 


<210>  3526
<211>  2144
<212>  DNA
<213>  Homosapiens

<400>  3526
gctgaagaca gagcgatggt agttctggag gcctcgctcc ggggccgacc cgaggccaca     60

gtgcctccgc ggtagaccgg acttgggtga cgggctccgg gctcccgagg tgaagagcat    120

cgggggctga gggatggaag ggtctaagac gtccaacaac agcaccatgc aggtgagctt    180

cgtgtgccag cgctgcagcc agcccctgaa actggacacg agtttcaaga tcctggaccg    240

tgtcaccatc caggaactca cagctccatt acttaccaca gcccaggcga aaccaggaga    300

gacccaggag gaagagacta actcaggaga ggagccattt attgaaactc ctcgccagga    360

tggtgtctct cgcagattca tccccccagc caggatgatg tccacagaaa gtgccaacag    420

cttcactctg attggggagg catctgatgg cggcaccatg gagaacctca gccgaagact    480

gaaggtcact ggggaccttt ttgacatcat gtcgggccag acagatgtgg atcacccact    540

ctgtgaggaa tgcacagata ctcttttaga ccagctggac actcagctca acgtcactga    600

aaatgagtgt cagaactaca aacgctgttt ggagatctta gagcaaatga atgaggatga    660

cagtgaacag ttacagatgg agctaaagga gctggcacta gaggaggaga ggctgatcca    720

ggagctggaa gacgtggaaa agaaccgcaa gatagtggca gaaaatctcg agaaggtcca    780

ggctgaggct gagagactgg atcaggagga agctcagtat cagagagaat acagtgaatt    840

taaacgacag cagctggagc tggatgatga gctgaagagt gttgaaaacc agatgcgtta    900

tgcccagacg cagctggata agctgaagaa aaccaacgtc tttaatgcaa ccttccacat    960

ctggcacagt ggacagtttg gcacaatcaa taacttcagg ctgggtcgcc tgcccagtgt   1020

tcccgtggaa tggaatgaga ttaatgctgc ttggggccag actgtgttgc tgctccatgc   1080

tctggccaat aagatgggtc tgaaatttca gagataccga cttgttcctt acggaaacca   1140

ttcatatctg gagtctctga cagacaaatc taaggagctg ccgttatact gttctggggg   1200

gttgcggttt ttctgggaca acaagtttga ccatgcaatg gtggctttcc tggactgtgt   1260

gcagcagttc aaagaagagg ttgagaaagg cgagacacgt ttttgtcttc cctacaggat   1320

ggatgtggag aaaggcaaga ttgaagacac aggaggcagt ggcggctcct attccatcaa   1380

aacccagttt aactctgagg agcagtggac aaaagctctc aagttcatgc tgacgaatct   1440

taagtggggt cttgcttggg tgtcctcaca attttataac aaatgacttt tttccttagg   1500

gggaggtttg ccttaaaggc ttttaatttt gttttgtttg caaacatgtt ttaaattaaa   1560

ttcgggtaat attaaacagt acatgtttac aataccaaaa aagaaaaaat ccacaaaagc   1620

cactttattt taaaatatca tgtgacagat actttccaga gctacaacat gccatctata   1680

gttgccagcc ctggtcagtt ttgattctta accccatgga ctcctttccc tttcttctct   1740

gaaaaaaact aatttaaatt tgcttttctt ttttttaact gagttgaatt gagattgatg   1800

tgttttcact ggatttttat ctctctcaac ttcctgcact taacaatatg aaatagaaac   1860

ttttgtcttt actgagatga ggatatgttt gagatgcaca gttggataat gtgggaaaat   1920

gacatctaag ctttacctgg tcaccatgtg atgtgatcag atgcttgaaa tttaacactt   1980

ttcacttggt tcttatactg aatgccgact ctgctctgtg ttagagatat gaaatggtgt   2040

ttgatactgt ttgagacatt atggagagat ttaattattt gtaataaaag atttgctgca   2100

gtctgaaaac tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                    2144


<210>  3527
<211>  450
<212>  PRT
<213>  Homosapiens

<400>  3527

Met Glu Gly Ser Lys Thr Ser Asn Asn Ser Thr Met Gln Val Ser Phe 
1               5                   10                  15      


Val Cys Gln Arg Cys Ser Gln Pro Leu Lys Leu Asp Thr Ser Phe Lys 
            20                  25                  30          


Ile Leu Asp Arg Val Thr Ile Gln Glu Leu Thr Ala Pro Leu Leu Thr 
        35                  40                  45              


Thr Ala Gln Ala Lys Pro Gly Glu Thr Gln Glu Glu Glu Thr Asn Ser 
    50                  55                  60                  


Gly Glu Glu Pro Phe Ile Glu Thr Pro Arg Gln Asp Gly Val Ser Arg 
65                  70                  75                  80  


Arg Phe Ile Pro Pro Ala Arg Met Met Ser Thr Glu Ser Ala Asn Ser 
                85                  90                  95      


Phe Thr Leu Ile Gly Glu Ala Ser Asp Gly Gly Thr Met Glu Asn Leu 
            100                 105                 110         


Ser Arg Arg Leu Lys Val Thr Gly Asp Leu Phe Asp Ile Met Ser Gly 
        115                 120                 125             


Gln Thr Asp Val Asp His Pro Leu Cys Glu Glu Cys Thr Asp Thr Leu 
    130                 135                 140                 


Leu Asp Gln Leu Asp Thr Gln Leu Asn Val Thr Glu Asn Glu Cys Gln 
145                 150                 155                 160 


Asn Tyr Lys Arg Cys Leu Glu Ile Leu Glu Gln Met Asn Glu Asp Asp 
                165                 170                 175     


Ser Glu Gln Leu Gln Met Glu Leu Lys Glu Leu Ala Leu Glu Glu Glu 
            180                 185                 190         


Arg Leu Ile Gln Glu Leu Glu Asp Val Glu Lys Asn Arg Lys Ile Val 
        195                 200                 205             


Ala Glu Asn Leu Glu Lys Val Gln Ala Glu Ala Glu Arg Leu Asp Gln 
    210                 215                 220                 


Glu Glu Ala Gln Tyr Gln Arg Glu Tyr Ser Glu Phe Lys Arg Gln Gln 
225                 230                 235                 240 


Leu Glu Leu Asp Asp Glu Leu Lys Ser Val Glu Asn Gln Met Arg Tyr 
                245                 250                 255     


Ala Gln Thr Gln Leu Asp Lys Leu Lys Lys Thr Asn Val Phe Asn Ala 
            260                 265                 270         


Thr Phe His Ile Trp His Ser Gly Gln Phe Gly Thr Ile Asn Asn Phe 
        275                 280                 285             


Arg Leu Gly Arg Leu Pro Ser Val Pro Val Glu Trp Asn Glu Ile Asn 
    290                 295                 300                 


Ala Ala Trp Gly Gln Thr Val Leu Leu Leu His Ala Leu Ala Asn Lys 
305                 310                 315                 320 


Met Gly Leu Lys Phe Gln Arg Tyr Arg Leu Val Pro Tyr Gly Asn His 
                325                 330                 335     


Ser Tyr Leu Glu Ser Leu Thr Asp Lys Ser Lys Glu Leu Pro Leu Tyr 
            340                 345                 350         


Cys Ser Gly Gly Leu Arg Phe Phe Trp Asp Asn Lys Phe Asp His Ala 
        355                 360                 365             


Met Val Ala Phe Leu Asp Cys Val Gln Gln Phe Lys Glu Glu Val Glu 
    370                 375                 380                 


Lys Gly Glu Thr Arg Phe Cys Leu Pro Tyr Arg Met Asp Val Glu Lys 
385                 390                 395                 400 


Gly Lys Ile Glu Asp Thr Gly Gly Ser Gly Gly Ser Tyr Ser Ile Lys 
                405                 410                 415     


Thr Gln Phe Asn Ser Glu Glu Gln Trp Thr Lys Ala Leu Lys Phe Met 
            420                 425                 430         


Leu Thr Asn Leu Lys Trp Gly Leu Ala Trp Val Ser Ser Gln Phe Tyr 
        435                 440                 445             


Asn Lys 
    450 


<210>  3528
<211>  3299
<212>  DNA
<213>  Homosapiens

<400>  3528
gggtgcttag ccccgccccc gtcccactct gccctgttgc tgtcgcgccg ctgctggttg     60

ctgtccctgg acccctacca tggaggagac catcaaagat ccccccacat cagctgtctt    120

gctggatcac tgtcatttct ctcaggtcat ctttaacagt gtggagaagt tctacatccc    180

tggaggggac gtcacatgtc attatacctt cacccagcat ttcatccctc gtcgaaagga    240

ttggattggc atctttagag tggggtggaa gacaacccgt gagtattaca ccttcatgtg    300

ggttactttg cccattgacc taaacaacaa atcagctaaa cagcaggaag tccaattcaa    360

agcttactac ctgcccaagg atgatgagta ttaccagttc tgctatgtgg atgaggatgg    420

tgtggtccgg ggagcaagta ttcctttcca attccgtcca gaaaatgagg aagacatcct    480

ggttgttacc actcagggag aggtggaaga gattgagcag cacaacaagg agctttgcaa    540

agaaaaccag gagctgaagg acagctgtat cagcctccag aagcagaact cagacatgca    600

ggctgagctc caaaagaagc aggaggagct agaaacccta cagagcatca ataagaagtt    660

ggaactgaaa gtgaaagaac agaaggacta ttgggagaca gagctgcttc aactgaaaga    720

acaaaaccag aagatgtcct cagaaaatga gaagatggga atcagagtgg atcagcttca    780

ggcccagctg tcaactcaag agaaagaaat ggagaagctt gttcagggag atcaagataa    840

gacagagcag ttagagcagc tgaaaaagga aaatgaccac ctctttctca gtttaactga    900

acagaggaag gaccagaaga agctcgagca gacagtggag caaatgaagc agaatgaaac    960

tactgcaatg aagaaacaac aggaattaat ggatgaaaac tttgacctgt caaaaagact   1020

gagtgagaac gaaattatat gtaatgctct gcagagacag aaagagagat tggaaggaga   1080

aaatgatctt ttgaagaggg agaacagcag attgctcagt tacatgggtc tggattttaa   1140

ttctttgccg tatcaagtac ctacttcaga tgaaggaggc gcaagacaaa atccaggact   1200

tgcctatgga aacccatatt ctggtatcca agaaagttct tcccccagcc cgctctccat   1260

caagaaatgc cctatctgca aagcagatga tatttgtgat cacaccttgg agcaacagca   1320

gatgcagccc ctttgtttca attgtccaat ttgtgacaag atcttcccag ctacagagaa   1380

gcagatcttt gaagaccacg tgttctgcca ctctctctga gtatcccaac ctcttggatg   1440

tatacagaga ttttatagaa tagaacctat agcttctacc atgagttata tgagtcaaga   1500

tcctgcctaa cctgaaatta ttagggattt actcagccct gctgccgcta acagtggagt   1560

tatgtcactg atctgaaggt cactgttaag ggcttctgct gccatccttg tgggttgcta   1620

cctttaagtc gcataactct agctgtatca tcctctcacc tgtcattctt ctgagggtct   1680

cagtacaagg gccctgggat ggagccaacc tgggtattca caacaggcct gacttgatac   1740

taagtgatta gttttccaag ttgtcccact gccattcaaa gtcagccctt gagtgtattt   1800

gttctcagtc ctaaccctgg ggccagagat tggtccgagg ttgagaattc cttcctcctc   1860

atccttggtg ttgctttctc caaatgattg ttttagacta gccaaaaatg ccgtggcaaa   1920

gagctcagaa atccaatttg gataccaaag gtttctcatg ttaatttctc agcccccaaa   1980

gaagcatctt actcctgaac cttagacagg aagtattgtt tcagtcacag aaagcttttc   2040

tgggtacctc tggttagcac tttctactct ctgatatttc ctatgtacat agcttttatt   2100

gttgtaaatc ctttcttaat ggttaaatag gattgttagc aactatgggt ttgcagtttt   2160

ctgagtaggt gagttttgaa tatgggtaaa tcagaataat gagacaactt gttaatctct   2220

ttaatactaa aaataaatta ctcttctatt tcagggactt aggtaattta aaataaacct   2280

tcaatttatg gtcttctgtt ttgaagctca tgggaaaatt gtgatcaaaa gggctatggg   2340

aagggcagac cccgccaatg atttctcttc acctgtctta agattaaata aaaaagagtg   2400

tcctggcagt tatcttgagg tggggaagga ggtgatgaaa cattagtttg tgaaatccaa   2460

ggccctggct tgctttcttt cttttttttt tttttttttt gaaacagtct ctctctgtca   2520

cccaggctgg cgtgcaatgg cgcagttgac tcactacagc ctctgcctcc caggttcaag   2580

cgattctcat gccttagcct cccaagtagc tgggattaca ggtgtgtgcc gcaatgccca   2640

gctaattttt gtgtttttag tagagacagg gtttcactat gttggccagg ctggtctcga   2700

actcctggcc tcacgtgatc tgtccacttc agccgtccaa agtgctggga ttacaagcgt   2760

gagccactgt gctgggcccg aggccctgac ttcttgctgt aactttccat gcattttttt   2820

taaaaggagc agtgtggatt ttcgcaccct ttgtgaacta agttcaatgc gctctatcca   2880

aatttgccta attgaactat aagaaagtaa taattccatt ttctatcccc tcagggactg   2940

aacaaatgga aataactccc aggcagtatc aggtggtcac tacagagact tccacaaaaa   3000

cttttgaatg atgtgaaaca cgatgtcatg aataagggtt gagccaacta tagctctgtg   3060

ttcctactgg gctttcccta atgtggttgg gagttatgcc ctagactaac tgtattgtcc   3120

tagtcacagc tccttgcttt gatttcatcc ttgataaaat gaagatgaaa cttacactac   3180

ttctccaagc cttttgctgt cttaagaata agacctgaga ttaacactaa ccctagaata   3240

gaaatgtaat agggagatgg taataaagga gtttttctgg caaaaaaaaa aaaaaaaaa    3299


<210>  3529
<211>  446
<212>  PRT
<213>  Homosapiens

<400>  3529

Met Glu Glu Thr Ile Lys Asp Pro Pro Thr Ser Ala Val Leu Leu Asp 
1               5                   10                  15      


His Cys His Phe Ser Gln Val Ile Phe Asn Ser Val Glu Lys Phe Tyr 
            20                  25                  30          


Ile Pro Gly Gly Asp Val Thr Cys His Tyr Thr Phe Thr Gln His Phe 
        35                  40                  45              


Ile Pro Arg Arg Lys Asp Trp Ile Gly Ile Phe Arg Val Gly Trp Lys 
    50                  55                  60                  


Thr Thr Arg Glu Tyr Tyr Thr Phe Met Trp Val Thr Leu Pro Ile Asp 
65                  70                  75                  80  


Leu Asn Asn Lys Ser Ala Lys Gln Gln Glu Val Gln Phe Lys Ala Tyr 
                85                  90                  95      


Tyr Leu Pro Lys Asp Asp Glu Tyr Tyr Gln Phe Cys Tyr Val Asp Glu 
            100                 105                 110         


Asp Gly Val Val Arg Gly Ala Ser Ile Pro Phe Gln Phe Arg Pro Glu 
        115                 120                 125             


Asn Glu Glu Asp Ile Leu Val Val Thr Thr Gln Gly Glu Val Glu Glu 
    130                 135                 140                 


Ile Glu Gln His Asn Lys Glu Leu Cys Lys Glu Asn Gln Glu Leu Lys 
145                 150                 155                 160 


Asp Ser Cys Ile Ser Leu Gln Lys Gln Asn Ser Asp Met Gln Ala Glu 
                165                 170                 175     


Leu Gln Lys Lys Gln Glu Glu Leu Glu Thr Leu Gln Ser Ile Asn Lys 
            180                 185                 190         


Lys Leu Glu Leu Lys Val Lys Glu Gln Lys Asp Tyr Trp Glu Thr Glu 
        195                 200                 205             


Leu Leu Gln Leu Lys Glu Gln Asn Gln Lys Met Ser Ser Glu Asn Glu 
    210                 215                 220                 


Lys Met Gly Ile Arg Val Asp Gln Leu Gln Ala Gln Leu Ser Thr Gln 
225                 230                 235                 240 


Glu Lys Glu Met Glu Lys Leu Val Gln Gly Asp Gln Asp Lys Thr Glu 
                245                 250                 255     


Gln Leu Glu Gln Leu Lys Lys Glu Asn Asp His Leu Phe Leu Ser Leu 
            260                 265                 270         


Thr Glu Gln Arg Lys Asp Gln Lys Lys Leu Glu Gln Thr Val Glu Gln 
        275                 280                 285             


Met Lys Gln Asn Glu Thr Thr Ala Met Lys Lys Gln Gln Glu Leu Met 
    290                 295                 300                 


Asp Glu Asn Phe Asp Leu Ser Lys Arg Leu Ser Glu Asn Glu Ile Ile 
305                 310                 315                 320 


Cys Asn Ala Leu Gln Arg Gln Lys Glu Arg Leu Glu Gly Glu Asn Asp 
                325                 330                 335     


Leu Leu Lys Arg Glu Asn Ser Arg Leu Leu Ser Tyr Met Gly Leu Asp 
            340                 345                 350         


Phe Asn Ser Leu Pro Tyr Gln Val Pro Thr Ser Asp Glu Gly Gly Ala 
        355                 360                 365             


Arg Gln Asn Pro Gly Leu Ala Tyr Gly Asn Pro Tyr Ser Gly Ile Gln 
    370                 375                 380                 


Glu Ser Ser Ser Pro Ser Pro Leu Ser Ile Lys Lys Cys Pro Ile Cys 
385                 390                 395                 400 


Lys Ala Asp Asp Ile Cys Asp His Thr Leu Glu Gln Gln Gln Met Gln 
                405                 410                 415     


Pro Leu Cys Phe Asn Cys Pro Ile Cys Asp Lys Ile Phe Pro Ala Thr 
            420                 425                 430         


Glu Lys Gln Ile Phe Glu Asp His Val Phe Cys His Ser Leu 
        435                 440                 445     


<210>  3530
<211>  593
<212>  DNA
<213>  Homosapiens

<400>  3530
caggacacgt gggtggggga agctgagcgc tgagaccaag ggctaaagct gggagactga     60

aaaaatgcag accgccgggg cattattcat ttctccagct ctgatccgct gttgtaccag    120

gggtctaatc aggcctgtgt ctgcctcctt cttgaatagc ccagtgaatt catctaaaca    180

gccttcctac agcaacttcc cactccaggt ggccagacgg gagttccaga ccagtgttgt    240

ctcccgggac attgacacag cagccaagtt tattggtgct ggggcagcca cagttggtgt    300

ggctggttca ggggctggca ttggaaccgt gtttggcagc ttgatcattg gctatgccag    360

gaacccgtct ctcaagcagc agctcttctc ctatgccatt cttggctttg ccctgtctga    420

ggccatgggg cttttctgtt tgatggtcgc cttcctcatc ctcttcgcca tgtgaggctc    480

catggggggt caccggcctg ttgctactgc aactccacac cattcttggt gctggggtgt    540

gttaagcttt accattaaac acaacgtttc tctaaaaaaa aaaaaaaaaa aaa           593


<210>  3531
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  3531

Met Gln Thr Ala Gly Ala Leu Phe Ile Ser Pro Ala Leu Ile Arg Cys 
1               5                   10                  15      


Cys Thr Arg Gly Leu Ile Arg Pro Val Ser Ala Ser Phe Leu Asn Ser 
            20                  25                  30          


Pro Val Asn Ser Ser Lys Gln Pro Ser Tyr Ser Asn Phe Pro Leu Gln 
        35                  40                  45              


Val Ala Arg Arg Glu Phe Gln Thr Ser Val Val Ser Arg Asp Ile Asp 
    50                  55                  60                  


Thr Ala Ala Lys Phe Ile Gly Ala Gly Ala Ala Thr Val Gly Val Ala 
65                  70                  75                  80  


Gly Ser Gly Ala Gly Ile Gly Thr Val Phe Gly Ser Leu Ile Ile Gly 
                85                  90                  95      


Tyr Ala Arg Asn Pro Ser Leu Lys Gln Gln Leu Phe Ser Tyr Ala Ile 
            100                 105                 110         


Leu Gly Phe Ala Leu Ser Glu Ala Met Gly Leu Phe Cys Leu Met Val 
        115                 120                 125             


Ala Phe Leu Ile Leu Phe Ala Met 
    130                 135     


<210>  3532
<211>  663
<212>  DNA
<213>  Homosapiens

<400>  3532
caggacacgt gggtggggga agctgagcgc tgagaccaag ggctaaagct gggaggtgag     60

tctgtcacct tgagccgggc gagcgctgtg ggccaagcag gggttgcagg gtagtaggag    120

tgcagactga aaaaatgcag accgccgggg cattattcat ttctccagct ctgatccgct    180

gttgtaccag gggtctaatc aggcctgtgt ctgcctcctt cttgaatagc ccagtgaatt    240

catctaaaca gccttcctac agcaacttcc cactccaggt ggccagacgg gagttccaga    300

ccagtgttgt ctcccgggac attgacacag cagccaagtt tattggtgct ggggcagcca    360

cagttggtgt ggctggttca ggggctggca ttggaaccgt gtttggcagc ttgatcattg    420

gctatgccag gaacccgtct ctcaagcagc agctcttctc ctatgccatt cttggctttg    480

ccctgtctga ggccatgggg cttttctgtt tgatggtcgc cttcctcatc ctcttcgcca    540

tgtgaggctc catggggggt caccggcctg ttgctactgc aactccacac cattcttggt    600

gctggggtgt gttaagcttt accattaaac acaacgtttc tctaaaaaaa aaaaaaaaaa    660

aaa                                                                  663


<210>  3533
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  3533

Met Gln Thr Ala Gly Ala Leu Phe Ile Ser Pro Ala Leu Ile Arg Cys 
1               5                   10                  15      


Cys Thr Arg Gly Leu Ile Arg Pro Val Ser Ala Ser Phe Leu Asn Ser 
            20                  25                  30          


Pro Val Asn Ser Ser Lys Gln Pro Ser Tyr Ser Asn Phe Pro Leu Gln 
        35                  40                  45              


Val Ala Arg Arg Glu Phe Gln Thr Ser Val Val Ser Arg Asp Ile Asp 
    50                  55                  60                  


Thr Ala Ala Lys Phe Ile Gly Ala Gly Ala Ala Thr Val Gly Val Ala 
65                  70                  75                  80  


Gly Ser Gly Ala Gly Ile Gly Thr Val Phe Gly Ser Leu Ile Ile Gly 
                85                  90                  95      


Tyr Ala Arg Asn Pro Ser Leu Lys Gln Gln Leu Phe Ser Tyr Ala Ile 
            100                 105                 110         


Leu Gly Phe Ala Leu Ser Glu Ala Met Gly Leu Phe Cys Leu Met Val 
        115                 120                 125             


Ala Phe Leu Ile Leu Phe Ala Met 
    130                 135     


<210>  3534
<211>  3053
<212>  DNA
<213>  Homosapiens

<400>  3534
gcgatggcgg agagtccgac tgaggaggcg gcaacggcgg gcgccggggc ggcgggcccc     60

ggggcgagca gcgttgctgg tgttgttggc gttagcggca gcggcggcgg gttcgggccg    120

cctttcctgc cggatgtgtg ggcggcggcg gcggcagcgg gcggggccgg gggcccgggg    180

agcggcctgg ctccgctgcc cgggctcccg ccctcagccg ctgcccacgg ggccgcgctg    240

cttagccact gggaccccac gctcagctcc gactgggacg gcgagcgcac cgcgccgcag    300

tgtctactcc ggatcaagcg ggatatcatg tccatttata aggagcctcc tccaggaatg    360

ttcgttgtac ctgatactgt tgacatgact aagattcatg cattgatcac aggcccattt    420

gacactcctt atgaaggggg tttcttcctg ttcgtgtttc ggtgtccgcc cgactatccc    480

atccacccac ctcgggtcaa actgatgaca acgggcaata acacagtgag gtttaacccc    540

aacttctacc gcaatgggaa agtctgcttg agtattctag gtacatggac tggacctgcc    600

tggagcccag cccagagcat ctcctcagtg ctcatctcta tccagtccct gatgactgag    660

aacccctatc acaatgagcc cggctttgaa caggagagac atccaggaga cagcaaaaac    720

tataatgaat gtatccggca cgagaccatc agagttgcag tctgtgacat gatggaagga    780

aagtgtccct gtcctgaacc cctacgaggg gtgatggaga agtcctttct ggagtattac    840

gacttctatg aggtggcctg caaagatcgc ctgcaccttc aaggccaaac tatgcaggac    900

ccttttggag agaagcgggg ccactttgac taccagtccc tcttgatgcg cctgggactg    960

atacgtcaga aagtgctgga gaggctccat aatgagaatg cagaaatgga ctctgatagc   1020

agttcatctg ggacagagac agaccttcat gggagcctga gggtttagac cctgctccca   1080

tctccccttc ccccactcaa gagtcccagc agaatccctt ccccccaccc cagggatgga   1140

gaggcactgt gtatctccct ccagactcga agtcatcctg caagatggca agaaccaagc   1200

aagctccgat cccagggtgt gggagtgggg gcctgttccc ggtctgacct ccttggcact   1260

ggagcatctg gggcttcgtt catccattca tcccgtatca ggggccaagg tacctttaca   1320

ggagcaccta gagcgagggc ctttggcaaa aacaaaacaa ccaacacacc tctccacagg   1380

gccagctcct tagggataag tggaagatgg aaattgcaat tccaagaggg agtgtgccca   1440

aatgatttat ggggatacct ggaagggagc ttggggtggg ggctgtctgt gacacttaag   1500

cagtctgggt ggttgtctat ttgtctgtct tcagtcttga agcagggctt cccaatgccc   1560

ttttcctccc tgccttcctt cccccattat ttcccacagg ccagcataat tttgtttttc   1620

ctaatttata gtcactgttc tagacagacc aaagagaagg aacagtggtg gagtctaggc   1680

tgctgatcag taagctttac ctagcacctg agcacctttc tcccctcccc tctttcctca   1740

cccttttcta gatgtaagac agaaggtaaa tgtgactggg acttaaccaa ggtcttggta   1800

aagcctgcat ggcaccgtaa gaagctgaaa atactgtttg ttcccgcaat cactgatttg   1860

aaaagttccc aacacaggca gctgctgtgt atatgggatt agagccacta catagaatag   1920

tctcttacag attttcataa atactagtca caataagggt atttttcttg ggggtggagt   1980

aagggggaga ctgatgctag tccttgttgt attttgttgg gctgtccttg tgtattttca   2040

ccccagcctg tagtcctcct cacttcaacc ccagggattt gtggggagca agggtagcca   2100

atggcagagg gggttggggc tgggactctg gaggctcctc cccttctttc tcttccttct   2160

gcctcccccg tgcccccagc tgctcttgtc actgtctctg atgggtattt gcctggcttt   2220

gttgcttctc tatctgtatt tagctgcagt gatcctttag ctggttggct cagaaaaaaa   2280

aaaatgtgct ttaggtgccc tgtaatcctg ggcatcaagg gaatccatcc ttcccctttt   2340

tgatatgttc tccccgtact tccagattta ttgttatggc tcccagtggg tattggcgat   2400

tcttgtgatg cagggcctca gtcagtgtcc agccatgcat aagggagagg atagtgtgta   2460

cctgccctgc cctctgctat gaaggtctct gccttgtgga tcatgggact ccccttggag   2520

gatctgtgca aaggggggct gggcacaaag gagaatgtcc tatttgggag ggcaggaagc   2580

aaaggaactg gacagggatt ggtgggcttg gggaacggaa gtttatcttg gatacccttg   2640

aagaggctgg gtctcttcac atgaagatcg aaaagggacc ctgcttccaa tttccctctt   2700

ccattcctcg agctactcca gggcttagaa gaatgctctt ggtctgtggg tccagtgttg   2760

tctgtcatcc atttaagtgt tcccactttc aagtgacaat cctctccttg gccctgccat   2820

agggcagagc atgtctggca tagcagcctg acttttatgc cctaatcttg agttgaggaa   2880

atatatgcac aggagtcaaa gagatgtctt tatatctgac tgtatataaa tgaagttttt   2940

ttgttttttt tgttttcctt tttggtgcaa taaagtttgt tttggcagaa aaaaaaaaaa   3000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa          3053


<210>  3535
<211>  246
<212>  PRT
<213>  Homosapiens

<400>  3535

Met Ser Ile Tyr Lys Glu Pro Pro Pro Gly Met Phe Val Val Pro Asp 
1               5                   10                  15      


Thr Val Asp Met Thr Lys Ile His Ala Leu Ile Thr Gly Pro Phe Asp 
            20                  25                  30          


Thr Pro Tyr Glu Gly Gly Phe Phe Leu Phe Val Phe Arg Cys Pro Pro 
        35                  40                  45              


Asp Tyr Pro Ile His Pro Pro Arg Val Lys Leu Met Thr Thr Gly Asn 
    50                  55                  60                  


Asn Thr Val Arg Phe Asn Pro Asn Phe Tyr Arg Asn Gly Lys Val Cys 
65                  70                  75                  80  


Leu Ser Ile Leu Gly Thr Trp Thr Gly Pro Ala Trp Ser Pro Ala Gln 
                85                  90                  95      


Ser Ile Ser Ser Val Leu Ile Ser Ile Gln Ser Leu Met Thr Glu Asn 
            100                 105                 110         


Pro Tyr His Asn Glu Pro Gly Phe Glu Gln Glu Arg His Pro Gly Asp 
        115                 120                 125             


Ser Lys Asn Tyr Asn Glu Cys Ile Arg His Glu Thr Ile Arg Val Ala 
    130                 135                 140                 


Val Cys Asp Met Met Glu Gly Lys Cys Pro Cys Pro Glu Pro Leu Arg 
145                 150                 155                 160 


Gly Val Met Glu Lys Ser Phe Leu Glu Tyr Tyr Asp Phe Tyr Glu Val 
                165                 170                 175     


Ala Cys Lys Asp Arg Leu His Leu Gln Gly Gln Thr Met Gln Asp Pro 
            180                 185                 190         


Phe Gly Glu Lys Arg Gly His Phe Asp Tyr Gln Ser Leu Leu Met Arg 
        195                 200                 205             


Leu Gly Leu Ile Arg Gln Lys Val Leu Glu Arg Leu His Asn Glu Asn 
    210                 215                 220                 


Ala Glu Met Asp Ser Asp Ser Ser Ser Ser Gly Thr Glu Thr Asp Leu 
225                 230                 235                 240 


His Gly Ser Leu Arg Val 
                245     


<210>  3536
<211>  1226
<212>  DNA
<213>  Homosapiens

<400>  3536
ccgggacgtg gagacccggg gtcccggcag ccgggcggcc cgcgggccca gggtggggat     60

gcaccgccgc ggggtgggag ctggcgccat cgccaagaag aaacttgcag aggccaagta    120

taaggagcga gggacggtct tggctgagga ccagctagcc cagatgtcaa agcagttgga    180

catgttcaag accaacctgg aggaatttgc cagcaaacac aagcaggaga tccggaagaa    240

tcctgagttc cgtgtgcagt tccaggacat gtgtgcaacc attggcgtgg atccgctggc    300

ctctggaaaa ggattttggt ctgagatgct gggcgtgggg gacttctatt acgaactagg    360

tgtccaaatt atcgaagtgt gcctggcgct gaagcatcgg aatggaggtc tgataacttt    420

ggaggaacta catcaacagg tgttgaaggg aaggggcaag ttcgcccagg atgtcagtca    480

agatgacctg atcagagcca tcaagaaact aaaggcactt ggcactggct tcggcatcat    540

ccctgtgggc ggcacttacc tcattcagtc tgttccagct gagctcaata tggatcacac    600

cgtggtgctg cagctggcag agaagaatgg ctacgtgact gtcagtgaga tcaaagccag    660

tcttaaatgg gagaccgagc gagcgcggca agtgctggaa cacctgctga aggaagggtt    720

ggcgtggctg gacttacagg ccccagggga ggcccactac tggctgccag ctctcttcac    780

tgacctctac tcccaggaga ttacagctga ggaggccaga gaagccctcc cctgactgca    840

tgtggaaggg cacacagcag caggcaggga ggaggcggag gtggcaaata aacctgggca    900

attttgttta tacaaaaaat agaaaaaaag ttccaagttt ttctttcttc cctcattctt    960

ttatttttga aaagtgcctt cacgttgcat ttttattgga ggaaaacctc gctcgttcag   1020

taagcataat ctgattaaca cagagaacgg caagcacata taaaatgatt tttgtaggtc   1080

atctgcaagt tcatggaaga gctgggccta gaatgtgggt tgtttcctgg cctgtctagt   1140

ctttgtagct gtgagacata gattacagcc tatgctaatt caaacctttt aaataaaatg   1200

ttccttatct caaaaaaaaa aaaaaa                                        1226


<210>  3537
<211>  258
<212>  PRT
<213>  Homosapiens

<400>  3537

Met His Arg Arg Gly Val Gly Ala Gly Ala Ile Ala Lys Lys Lys Leu 
1               5                   10                  15      


Ala Glu Ala Lys Tyr Lys Glu Arg Gly Thr Val Leu Ala Glu Asp Gln 
            20                  25                  30          


Leu Ala Gln Met Ser Lys Gln Leu Asp Met Phe Lys Thr Asn Leu Glu 
        35                  40                  45              


Glu Phe Ala Ser Lys His Lys Gln Glu Ile Arg Lys Asn Pro Glu Phe 
    50                  55                  60                  


Arg Val Gln Phe Gln Asp Met Cys Ala Thr Ile Gly Val Asp Pro Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Gly Phe Trp Ser Glu Met Leu Gly Val Gly Asp Phe 
                85                  90                  95      


Tyr Tyr Glu Leu Gly Val Gln Ile Ile Glu Val Cys Leu Ala Leu Lys 
            100                 105                 110         


His Arg Asn Gly Gly Leu Ile Thr Leu Glu Glu Leu His Gln Gln Val 
        115                 120                 125             


Leu Lys Gly Arg Gly Lys Phe Ala Gln Asp Val Ser Gln Asp Asp Leu 
    130                 135                 140                 


Ile Arg Ala Ile Lys Lys Leu Lys Ala Leu Gly Thr Gly Phe Gly Ile 
145                 150                 155                 160 


Ile Pro Val Gly Gly Thr Tyr Leu Ile Gln Ser Val Pro Ala Glu Leu 
                165                 170                 175     


Asn Met Asp His Thr Val Val Leu Gln Leu Ala Glu Lys Asn Gly Tyr 
            180                 185                 190         


Val Thr Val Ser Glu Ile Lys Ala Ser Leu Lys Trp Glu Thr Glu Arg 
        195                 200                 205             


Ala Arg Gln Val Leu Glu His Leu Leu Lys Glu Gly Leu Ala Trp Leu 
    210                 215                 220                 


Asp Leu Gln Ala Pro Gly Glu Ala His Tyr Trp Leu Pro Ala Leu Phe 
225                 230                 235                 240 


Thr Asp Leu Tyr Ser Gln Glu Ile Thr Ala Glu Glu Ala Arg Glu Ala 
                245                 250                 255     


Leu Pro 
        


<210>  3538
<211>  711
<212>  DNA
<213>  Homosapiens

<400>  3538
aggctcagaa ggtccagaaa tcaggggaag gagaccccta tctgtccttc ttctggaaga     60

gctggaaagg aagtctgctc aggaaataac cttggaagat ggtggccacg aagacctttg    120

ctctgctgct gctgtccctg ttcctggcag tgggactagg agagaagaaa gagggtcact    180

tcagcgctct cccctccctg cctgttggat ctcatgctaa ggtgagcagc cctcaacctc    240

gaggccccag gtacgcggaa gggactttca tcagtgacta cagtattgcc atggacaaga    300

ttcaccaaca agactttgtg aactggctgc tggcccaaaa ggggaagaag aatgactgga    360

aacacaacat cacccagagg gaggctcggg cgctggagct ggccagtcaa gctaatagga    420

aggaggagga ggcagtggag ccacagagct ccccagccaa gaaccccagc gatgaagatt    480

tgctgcggga cttgctgatt caagagctgt tggcctgctt gctggatcag acaaacctct    540

gcaggctcag gtctcggtga ctctgaccac acccagctca ggactggatt ctgcccttca    600

cttagcacct gcctcagccc cactccagaa tagccaagag aacccaaacc aataaagttt    660

atgctaagtc gagcccattg tgaaaattta ttaaaatgac tactgagcac t             711


<210>  3539
<211>  153
<212>  PRT
<213>  Homosapiens

<400>  3539

Met Val Ala Thr Lys Thr Phe Ala Leu Leu Leu Leu Ser Leu Phe Leu 
1               5                   10                  15      


Ala Val Gly Leu Gly Glu Lys Lys Glu Gly His Phe Ser Ala Leu Pro 
            20                  25                  30          


Ser Leu Pro Val Gly Ser His Ala Lys Val Ser Ser Pro Gln Pro Arg 
        35                  40                  45              


Gly Pro Arg Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala 
    50                  55                  60                  


Met Asp Lys Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
65                  70                  75                  80  


Lys Gly Lys Lys Asn Asp Trp Lys His Asn Ile Thr Gln Arg Glu Ala 
                85                  90                  95      


Arg Ala Leu Glu Leu Ala Ser Gln Ala Asn Arg Lys Glu Glu Glu Ala 
            100                 105                 110         


Val Glu Pro Gln Ser Ser Pro Ala Lys Asn Pro Ser Asp Glu Asp Leu 
        115                 120                 125             


Leu Arg Asp Leu Leu Ile Gln Glu Leu Leu Ala Cys Leu Leu Asp Gln 
    130                 135                 140                 


Thr Asn Leu Cys Arg Leu Arg Ser Arg 
145                 150             


<210>  3540
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3540
atttagaggc ggcgccaggg cggccgcgga gaaacgtgac acaccagccc tctcggaggg     60

gtttcggacc gaagggaaga agctgcgccg tgtcgtccgt ctccctgcgc gccgcgggca    120

cttctcctgg gctctccccg aactctcccg cgacctctgc gcgccctcag gccgccttcc    180

ccgccctggg ctcgggacaa cttctggggt ggggtgcaaa gaaagtttgc ggctcctgcc    240

gccggcctct ccgcctcttg gcctaggagg ctcgccgccc gcgcccgctc gttcggcctt    300

gcccgggacc gcgtcctgcc ccgagaccgc caccatgaac aagctttaca tcggcaacct    360

caacgagagc gtgacccccg cggacttgga gaaagtgttt gcggagcaca agatctccta    420

cagcggccag ttcttggtca aatccggcta cgccttcgtg gactgcccgg acgagcactg    480

ggcgatgaag gccatcgaaa ctttctccgg gaaagtagaa ttacaaggaa aacgcttaga    540

gattgaacat tcggtgccca aaaaacaaag gagccggaaa attcaaatcc gaaatattcc    600

accccagctc cgatgggaag tactggacag cctgctggct cagtatggta cagtagagaa    660

ctgtgagcaa gtgaacaccg agagtgagac ggcagtggtg aatgtcacct attccaaccg    720

ggagcagacc aggcaagcca tcatgaagct gaatggccac cagttggaga accatgccct    780

gaaggtctcc tacatccccg atgagcagat agcacaggga cctgagaatg ggcgccgagg    840

gggctttggc tctcggggtc agccccgcca gggctcacct gtggcagcgg gggccccagc    900

caagcagcag caagtggaca tcccccttcg gctcctggtg cccacccagt atgtgggtgc    960

cattattggc aaggaggggg ccaccatccg caacatcaca aaacagaccc agtccaagat   1020

agacgtgcat aggaaggaga acgcaggtgc agctgaaaaa gccatcagtg tgcactccac   1080

ccctgagggc tgctcctccg cttgtaagat gatcttggag attatgcata aagaggctaa   1140

ggacaccaaa acggctgacg aggttcccct gaagatcctg gcccataata actttgtagg   1200

gcgtctcatt ggcaaggaag gacggaacct gaagaaggta gagcaagata ccgagacaaa   1260

aatcaccatc tcctcgttgc aagaccttac cctttacaac cctgagagga ccatcactgt   1320

gaagggggcc atcgagaatt gttgcagggc cgagcaggaa ataatgaaga aagttcggga   1380

ggcctatgag aatgatgtgg ctgccatgag cctgcagtct cacctgatcc ctggcctgaa   1440

cctggctgct gtaggtcttt tcccagcttc atccagcgca gtcccgccgc ctcccagcag   1500

cgttactggg gctgctccct atagctcctt tatgcaggct cccgagcagg agatggtgca   1560

ggtgtttatc cccgcccagg cagtgggcgc catcatcggc aagaaggggc agcacatcaa   1620

acagctctcc cggtttgcca gcgcctccat caagattgca ccacccgaaa cacctgactc   1680

caaagttcgt atggttatca tcactggacc gccagaggcc caattcaagg ctcagggaag   1740

aatctatggc aaactcaagg aggagaactt ctttggtccc aaggaggaag tgaagctgga   1800

gacccacata cgtgtgccag catcagcagc tggccgggtc attggcaaag gtggaaaaac   1860

ggtgaacgag ttgcagaatt tgacggcagc tgaggtggta gtaccaagag accagacccc   1920

tgatgagaac gaccaggtca tcgtgaaaat catcggacat ttctatgcca gtcagatggc   1980

tcaacggaag atccgagaca tcctggccca ggttaagcag cagcatcaga agggacagag   2040

taaccaggcc caggcacgga ggaagtgacc agcccctccc tgtcccttcg agtccaggac   2100

aacaacgggc agaaatcgag agtgtgctct ccccggcagg cctgagaatg agtgggaatc   2160

cgggacacct gggccgggct gtagatcagg tttgcccact tgattgagaa agatgttcca   2220

gtgaggaacc ctgatctctc agccccaaac acccacccaa ttggcccaac actgtctgcc   2280

cctcggggtg tcagaaattc tagcgcaagg cacttttaaa cgtggattgt ttaaagaagc   2340

tctccaggcc ccaccaagag ggtggatcac acctcagtgg gaagaaaaat aaaatttcct   2400

tcaggtttta aaaacatgca gagaggtgtt ttaatcagcc ttaaaggatg gttcatttct   2460

tgaccttaat gtttttccaa tcttcttccc cctacttggg taattgatta aaatacctcc   2520

atttacggcc tctttctata tttacactaa tttttttatc tttattgcta ccagaaaaaa   2580

atgcgaacga atgcattgct ttgcttacag tattgactca agggaaaaga actgtcagta   2640

tctgtagatt aattccaatc actccctaac caataggtac aatacggaat gaagaagagg   2700

ggaaaatggg gagaaagatg gttaaaatac ataataatcc acgtttaaaa ggagcgcact   2760

tgtggctgat ctatgccaga tcaccatctt caaattggca caactgaaat ttccccactc   2820

tgttggggct tccccaccac attcatgtcc ctctcccgtg taggtttcac attatgtcca   2880

ggtgcacata ggtggtattg aatgctcagc agggtagggg ctgaccactg tccctgattc   2940

ccatcgttct caggcggatt ttatattttt ttaaagtcta ttttaatgat tggatatgag   3000

cactgggaag gggacgctaa ctccccttga taaagtctcg gttccatgga ggacttgagt   3060

ggccccaaag gctgccacgg tgccctcacc ccagcccatg tgctcccata agggctggtt   3120

cctagaggca ggggttgtgg ggcactccca gccacggcac tgttaccttg gtggtgggac   3180

ttggaaccca accctgagct cccgataaag ctaaagtcca tcatctggca aattcagtaa   3240

attggagagt acttgcttct gtttgtatct gagaggaatt tttaactgac ggcttctgtc   3300

tccatgaatc attatcagca tgatgaaagg tgtgtctaaa aaacaattca gaataccagc   3360

agcattgtac agcaaggggt aaataagctt aatttattaa tttaccaggc ttaattaaga   3420

tcccatggag tgtttagccc ttgtgggaga cagaagccat cagttaaatg aggttaggcc   3480

tctcctccta atatactgat tgacaatgca tattagccag gtaatgcact ttagctaccc   3540

tggacaatgc tatcaagtgt gctgggaagg gaggaaggcc tctctacata tggaaaagcc   3600

catgcgtgga gttcccctcc tttcaacatt gcaacaacag taacaacaag acaaccgcaa   3660

catgtgggcg tagtcaggca atgctgtgtg cgaagtaaac tacctcaagg tatgaagtta   3720

cctcagcaat tattttcctt tttgttcccc ccaaccccat taaaaaaatt tttttttgat   3780

ttttgttttt ttgcagcttg ctgatatttt atataaaaaa gaaaagcaaa gcaaaagaga   3840

agctgatagt cttgaatatt ttattttttt aatgaaaaga aaaaacaaga aagttatgtt   3900

tcataatttc ttacaacatg agccagtaac cctttaggaa ctctctatgg agaacaggcc   3960

tggtgggaaa ggctttgggg gctgccccct taggaggagg ctagtgctaa gagggaaggc   4020

ccaggtttga gagagcccag aggggcagag cccagagcct tgtttggccc tgatctctga   4080

cttctagagc cccagctgct ggcggctgct ggaatatcct acctgatagg attaaaaggc   4140

ctagtggagc tgggggctct cagtggttaa acaatgccca acaaccaacc agctggccct   4200

tggtctcctc tctttcctcc tttggttaaa gagcatctca gccagctttt cccaccagtg   4260

gtgctgttga gatattttaa aatattgcct ccgttttatc gaggagagaa ataataacta   4320

aaaaatatac cctttaaaaa aacctatatt tctctgtcta aaaatatggg agctgagatt   4380

ccgttcgtgg aaaaaagaca aggccaccct ctcgccctca gagaggtcca cctggtttgt   4440

cattgcaatg cttttcattt tttttttttg ttattgtttc atttcagttc cgtcttgcta   4500

ttcttcctaa tctatatcca tagatctaag gggcaaacag atactagtta actgccccca   4560

cctctgtctc cctgtcttct ttagatcggt ctgattgatt ttaaaagtgg acccaaactt   4620

agggaattct tgatttaggg tggctggtgg caaggagggg caggggatat ggggacgtga   4680

ctgggacagg ttcctgcctt atcattttct ccctaggaca ttcccttgta gcccccagaa   4740

ttgtctggcc caaattgaat agaagcagaa aaacatttag ggataacatc aggccagtag   4800

aattaagcct ctccacctgt cccaaccata aaaagggtct cccagctttc catctctggc   4860

tctatatgct ttatcccaaa acaaagcaga taacgttcag acgtcggcca tttagtaatt   4920

taaagcgaat ttccagcagc aagcatgctt tgatatctgg ttcagactat catcaggaag   4980

aaaaaaaaat cccacagtac ctgaaatgtg attgttgcag tgttcagttt ccttgggggc   5040

ctgctccctt cacaccttga gcccaagtcc ttttccgttg gctgattcag ctcccagaag   5100

agacgaggaa gtgtgtggca agggactgga aaacttcact tgcttggatt aggcaaggct   5160

ccactcattg ttgatatttg cccagcagga aaatcatgta agttatacca ccagaaagca   5220

aaaggagcat ggtttggtgg ttaaggttta gtgggatgaa ggacctgtct tggtgggccg   5280

ggccctcttg tgccccgtag gctaggtctt agggcaactc cttgccctcc tgctcagcac   5340

ctccatttcc ccatccttgg tgagataaca agctatcgcg aaaagcactt gggagatttg   5400

gatgatttga gaagagtgac ttaaaaaaaa tgcttctgtg ctctaagata tatatgtgtg   5460

tgtgtgtgct acatatatat ttttaagaaa ggaccatctc tttaggatat atttttaaat   5520

tctttgaaac acataaccaa aatggtttga ttcactgact gactttgaag ctgcatctgc   5580

cagttacacc ccaaatggct ttaatcccct ctcgggtctg gttgcctttt gcagtttggg   5640

ttgtggactc agctcctgtg aggggtctgg ttaggagaga gccattttta aggacaggga   5700

gttttatagc ccttttctac tttcctcccc tcctcccagt ccttatcaat cttttttcct   5760

ttttcctgac cccctccttc tggaggcagt tgggagctat ccttgtttat gcctcactat   5820

tggcagaaaa gaccccattt aaaacccaga gaacactgga gggggatgct ctagttggtt   5880

ctgtgtccat tttcctctgt gccaaagaca gacagacaga ggctgagaga ggctgttcct   5940

gaatcaaagc aatagccagc tttcgacaca tacctggctg tctgaggagg aaggcctcct   6000

ggaaactggg agctaagggc gaggcccttc ccttcagagg ctcctggggg attagggtgt   6060

ggtgtttgcc aagccaaggg gtagggagcc gagaaattgg tctgtcggct cctggttgca   6120

ctttggggaa ggagaggaag tttggggctc caggtagctc cctgttgtgg gactgctctg   6180

tcccctgccc ctactgcaga gatagcactg ccgagttccc ttcaggcctg gcagacgggc   6240

agtgaggagg ggcctcagtt agctctcaag ggtgccttcc cctcctccca acccagacat   6300

accctctgcc aaactgggaa ccagcagtgc tagtaactac ctcacagagc cccagagggc   6360

ctgcttgagc cttcttgctc cacaggagaa gctggtgcct ctaggcaacc ccttcctccc   6420

acctctcatc aggggtgggg gttctccttt ctttcccctg aagtgtttat ggggagatcc   6480

tagtggcttt gccattcaaa ccactcgact gtttgcctgt ttcttgaaaa ccagtagaag   6540

ggaaacagca cagcctgtca cagtaattgc aggaagattg aagaaaaatc ctcatcaatg   6600

ccaggggaca taaaagccat ttcccttcca aatactcgac aatttagatg cagaacattt   6660

ctctgtattc agacttagag taacaccagc tgaaaactgc agtttctttc ctttggatac   6720

ataaggcttc tctatcgggg tacgggacag ggaggaggcc tcatgtctga agggggattt   6780

aggggcgaga gccccagccc tgaccctcgg tcctgtgcac cgctttgggg cacagtctga   6840

tggcgccttt gctggcgcct tagtatggtt gactccggat ggacaaaaga aaaaaaattt   6900

tttttcttga atgaaatagc aggaagctcc tcgggagcat gtgttttgat taaccgcagg   6960

tgatggatgc tacgagtata aatggattaa ctacctcaat ccttacagta agattggaac   7020

taagggcagg gactcatgca taagggtatg aatcccagcc aggacaagtg agttgaggct   7080

tgtgccacaa aaggtttgtc cttggggaac aggcaggcct gccaggatcc cccccatatc   7140

gattgggctg ggagggctgg ccatgaggtc cccactttct gctttccttg cccatgtgtc   7200

acccctttgg cctccagctt gtccctctct cactttctat agctttgttg gaccagatgg   7260

tgaggaaagg aatggcctct tcccttctag agggggctgg ctggagtgag acctggggct   7320

tggcctggaa cccaccacac agccccaaag tcaggaagcc tggggaaacc agagctgaga   7380

cctcttcaac agggtttctt tgagatccta cacctccatt gggccctttt tcagtcttca   7440

atgggggccc agttggctct agaaggagaa gaggtgaagc aggatccttt gccctggggg   7500

agtctgaggg cgcggtcctt ggactcattc aggccgtctt tgtagttggg ggagttccac   7560

tgggcgatcc cagcccctcc ccacccaccc tctaatggac ctcctcatag aagccccatt   7620

tcacttttgt tttatctacc tcttagcaaa acaatagata aattaggtag tggcagctcc   7680

acttgcttag gttagggggg gaaaaagatt tctttttcca aaggaaaaaa atattacctt   7740

gagaatactt tccaaaaaat aaaattaaaa aaaaaaaaac caaaaaaaaa aatttttttt   7800

taaaagggag acattttcca gtgaccactg gattgtttta atttcccaag cttttttttc   7860

ccccataaat aagtttcact ctttggcgat tttcttcact tgtttaagat aacgtgctag   7920

ctattccaac aggtaacagc tttcacagtc tgcccctggc ctgtctcacc ccatccccca   7980

ccctattcct gccagtgagt ccttcctgtg cttctctccc ttctcccctc ccagccagct   8040

gacttcagtc acccctgtcc cccctcccct gccaataagc tcccccagga ataaaggctt   8100

tgttttgggg atgcttaaat cttgactggc acttcccggc tgtgggggct ggggagccac   8160

ttgtaacatt tctgtgcaga ttttatgtta gc                                 8192


<210>  3541
<211>  577
<212>  PRT
<213>  Homosapiens

<400>  3541

Met Asn Lys Leu Tyr Ile Gly Asn Leu Asn Glu Ser Val Thr Pro Ala 
1               5                   10                  15      


Asp Leu Glu Lys Val Phe Ala Glu His Lys Ile Ser Tyr Ser Gly Gln 
            20                  25                  30          


Phe Leu Val Lys Ser Gly Tyr Ala Phe Val Asp Cys Pro Asp Glu His 
        35                  40                  45              


Trp Ala Met Lys Ala Ile Glu Thr Phe Ser Gly Lys Val Glu Leu Gln 
    50                  55                  60                  


Gly Lys Arg Leu Glu Ile Glu His Ser Val Pro Lys Lys Gln Arg Ser 
65                  70                  75                  80  


Arg Lys Ile Gln Ile Arg Asn Ile Pro Pro Gln Leu Arg Trp Glu Val 
                85                  90                  95      


Leu Asp Ser Leu Leu Ala Gln Tyr Gly Thr Val Glu Asn Cys Glu Gln 
            100                 105                 110         


Val Asn Thr Glu Ser Glu Thr Ala Val Val Asn Val Thr Tyr Ser Asn 
        115                 120                 125             


Arg Glu Gln Thr Arg Gln Ala Ile Met Lys Leu Asn Gly His Gln Leu 
    130                 135                 140                 


Glu Asn His Ala Leu Lys Val Ser Tyr Ile Pro Asp Glu Gln Ile Ala 
145                 150                 155                 160 


Gln Gly Pro Glu Asn Gly Arg Arg Gly Gly Phe Gly Ser Arg Gly Gln 
                165                 170                 175     


Pro Arg Gln Gly Ser Pro Val Ala Ala Gly Ala Pro Ala Lys Gln Gln 
            180                 185                 190         


Gln Val Asp Ile Pro Leu Arg Leu Leu Val Pro Thr Gln Tyr Val Gly 
        195                 200                 205             


Ala Ile Ile Gly Lys Glu Gly Ala Thr Ile Arg Asn Ile Thr Lys Gln 
    210                 215                 220                 


Thr Gln Ser Lys Ile Asp Val His Arg Lys Glu Asn Ala Gly Ala Ala 
225                 230                 235                 240 


Glu Lys Ala Ile Ser Val His Ser Thr Pro Glu Gly Cys Ser Ser Ala 
                245                 250                 255     


Cys Lys Met Ile Leu Glu Ile Met His Lys Glu Ala Lys Asp Thr Lys 
            260                 265                 270         


Thr Ala Asp Glu Val Pro Leu Lys Ile Leu Ala His Asn Asn Phe Val 
        275                 280                 285             


Gly Arg Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Val Glu Gln 
    290                 295                 300                 


Asp Thr Glu Thr Lys Ile Thr Ile Ser Ser Leu Gln Asp Leu Thr Leu 
305                 310                 315                 320 


Tyr Asn Pro Glu Arg Thr Ile Thr Val Lys Gly Ala Ile Glu Asn Cys 
                325                 330                 335     


Cys Arg Ala Glu Gln Glu Ile Met Lys Lys Val Arg Glu Ala Tyr Glu 
            340                 345                 350         


Asn Asp Val Ala Ala Met Ser Leu Gln Ser His Leu Ile Pro Gly Leu 
        355                 360                 365             


Asn Leu Ala Ala Val Gly Leu Phe Pro Ala Ser Ser Ser Ala Val Pro 
    370                 375                 380                 


Pro Pro Pro Ser Ser Val Thr Gly Ala Ala Pro Tyr Ser Ser Phe Met 
385                 390                 395                 400 


Gln Ala Pro Glu Gln Glu Met Val Gln Val Phe Ile Pro Ala Gln Ala 
                405                 410                 415     


Val Gly Ala Ile Ile Gly Lys Lys Gly Gln His Ile Lys Gln Leu Ser 
            420                 425                 430         


Arg Phe Ala Ser Ala Ser Ile Lys Ile Ala Pro Pro Glu Thr Pro Asp 
        435                 440                 445             


Ser Lys Val Arg Met Val Ile Ile Thr Gly Pro Pro Glu Ala Gln Phe 
    450                 455                 460                 


Lys Ala Gln Gly Arg Ile Tyr Gly Lys Leu Lys Glu Glu Asn Phe Phe 
465                 470                 475                 480 


Gly Pro Lys Glu Glu Val Lys Leu Glu Thr His Ile Arg Val Pro Ala 
                485                 490                 495     


Ser Ala Ala Gly Arg Val Ile Gly Lys Gly Gly Lys Thr Val Asn Glu 
            500                 505                 510         


Leu Gln Asn Leu Thr Ala Ala Glu Val Val Val Pro Arg Asp Gln Thr 
        515                 520                 525             


Pro Asp Glu Asn Asp Gln Val Ile Val Lys Ile Ile Gly His Phe Tyr 
    530                 535                 540                 


Ala Ser Gln Met Ala Gln Arg Lys Ile Arg Asp Ile Leu Ala Gln Val 
545                 550                 555                 560 


Lys Gln Gln His Gln Lys Gly Gln Ser Asn Gln Ala Gln Ala Arg Arg 
                565                 570                 575     


Lys 
    


<210>  3542
<211>  1792
<212>  DNA
<213>  Homosapiens

<400>  3542
ataggtggct gcagaggcga ggtgacggcg cgtgcggaac gaactctgca cccccaggaa     60

tggggagcgc tggcttttcc gtgggaaaat tccacgtgga ggtggcctct cgcggccggg    120

aatgtgtctc ggggacgccc gagtgtggga atcggctcgg gagtgcgggc ttcggggatc    180

tctgcttgga actcagaggc gctgacccag cctggggccc gtttgctgcc cacgggagga    240

gccgccgtca gggctcgaga tttctgtggc tcctcaagat attggtcata atcctggtac    300

ttggcattgt tggatttatg ttcggaagca tgttccttca agcagtgttc agcagcccca    360

agccagaact cccaagtcct gccccgggtg tccagaagct gaagcttctg cctgaggaac    420

gtctcaggaa cctcttttcc tacgatggaa tctggctgtt cccgaaaaat cagtgcaaat    480

gtgaagccaa caaagagcag ggaggttaca actttcagga tgcctatggc cagagcgacc    540

tcccagcggt gaaagcgagg agacaggctg aatttgaaca ctttcagagg agagaagggc    600

tgccccgccc actgcccctg ctggtccagc ccaacctccc ctttgggtac ccagtccacg    660

gagtggaggt gatgcccctg cacacggttc ccatcccagg cctccagttt gaaggacccg    720

atgcccccgt ctatgaggtc accctgacag cttctctggg gacactgaac acccttgctg    780

atgtcccaga cagtgtggtg cagggcagag gccagaagca gctgatcatt tctaccagtg    840

accggaagct gttgaagttc attcttcagc acgtgacata caccagcacg gggtaccagc    900

accagaaggt agacatagtg agtctggagt ccaggtcctc agtggccaag tttccagtga    960

ccatccgcca tcctgtcata cccaagctat acgaccctgg accagagagg aagctcagaa   1020

acctggttac cattgctacc aagactttcc tccgccccca caagctcatg atcatgctcc   1080

ggagtattcg agagtattac ccagacttga ccgtaatagt ggctgatgac agccagaagc   1140

ccctggaaat taaagacaac cacgtggagt attacactat gccctttggg aagggttggt   1200

ttgctggtag gaacctggcc atatctcagg tcaccaccaa atacgttctc tgggtggacg   1260

atgattttct cttcaacgag gagaccaaga ttgaggtgct ggtggatgtc ctggagaaaa   1320

cagaactgga cgtggtaggc ggcagtgtgc tgggaaatgt gttccagttt aagttgttgc   1380

tggaacagag tgagaatggg gcctgccttc acaagaggat gggatttttc caacccctgg   1440

atggcttccc cagctgcgtg gtgaccagtg gcgtggtcaa cttcttcctg gcccacacgg   1500

agcgactcca aagagttggc tttgatcccc gcctgcaacg agtggctcac tcagaattct   1560

tcattgatgg gctagggacc ctactcgtgg ggtcatgccc agaagtgatt ataggtcacc   1620

agtctcggtc tccagtggtg gactcagaac tggctgccct agagaagacc tacaatacat   1680

accggtccaa caccctcacc cgggtccagt tcaagctggc cctccactac ttcaagaacc   1740

atctccaatg tgccgcataa aggtgtgagg gcataggaga aacactaggc tg           1792


<210>  3543
<211>  566
<212>  PRT
<213>  Homosapiens

<400>  3543

Met Gly Ser Ala Gly Phe Ser Val Gly Lys Phe His Val Glu Val Ala 
1               5                   10                  15      


Ser Arg Gly Arg Glu Cys Val Ser Gly Thr Pro Glu Cys Gly Asn Arg 
            20                  25                  30          


Leu Gly Ser Ala Gly Phe Gly Asp Leu Cys Leu Glu Leu Arg Gly Ala 
        35                  40                  45              


Asp Pro Ala Trp Gly Pro Phe Ala Ala His Gly Arg Ser Arg Arg Gln 
    50                  55                  60                  


Gly Ser Arg Phe Leu Trp Leu Leu Lys Ile Leu Val Ile Ile Leu Val 
65                  70                  75                  80  


Leu Gly Ile Val Gly Phe Met Phe Gly Ser Met Phe Leu Gln Ala Val 
                85                  90                  95      


Phe Ser Ser Pro Lys Pro Glu Leu Pro Ser Pro Ala Pro Gly Val Gln 
            100                 105                 110         


Lys Leu Lys Leu Leu Pro Glu Glu Arg Leu Arg Asn Leu Phe Ser Tyr 
        115                 120                 125             


Asp Gly Ile Trp Leu Phe Pro Lys Asn Gln Cys Lys Cys Glu Ala Asn 
    130                 135                 140                 


Lys Glu Gln Gly Gly Tyr Asn Phe Gln Asp Ala Tyr Gly Gln Ser Asp 
145                 150                 155                 160 


Leu Pro Ala Val Lys Ala Arg Arg Gln Ala Glu Phe Glu His Phe Gln 
                165                 170                 175     


Arg Arg Glu Gly Leu Pro Arg Pro Leu Pro Leu Leu Val Gln Pro Asn 
            180                 185                 190         


Leu Pro Phe Gly Tyr Pro Val His Gly Val Glu Val Met Pro Leu His 
        195                 200                 205             


Thr Val Pro Ile Pro Gly Leu Gln Phe Glu Gly Pro Asp Ala Pro Val 
    210                 215                 220                 


Tyr Glu Val Thr Leu Thr Ala Ser Leu Gly Thr Leu Asn Thr Leu Ala 
225                 230                 235                 240 


Asp Val Pro Asp Ser Val Val Gln Gly Arg Gly Gln Lys Gln Leu Ile 
                245                 250                 255     


Ile Ser Thr Ser Asp Arg Lys Leu Leu Lys Phe Ile Leu Gln His Val 
            260                 265                 270         


Thr Tyr Thr Ser Thr Gly Tyr Gln His Gln Lys Val Asp Ile Val Ser 
        275                 280                 285             


Leu Glu Ser Arg Ser Ser Val Ala Lys Phe Pro Val Thr Ile Arg His 
    290                 295                 300                 


Pro Val Ile Pro Lys Leu Tyr Asp Pro Gly Pro Glu Arg Lys Leu Arg 
305                 310                 315                 320 


Asn Leu Val Thr Ile Ala Thr Lys Thr Phe Leu Arg Pro His Lys Leu 
                325                 330                 335     


Met Ile Met Leu Arg Ser Ile Arg Glu Tyr Tyr Pro Asp Leu Thr Val 
            340                 345                 350         


Ile Val Ala Asp Asp Ser Gln Lys Pro Leu Glu Ile Lys Asp Asn His 
        355                 360                 365             


Val Glu Tyr Tyr Thr Met Pro Phe Gly Lys Gly Trp Phe Ala Gly Arg 
    370                 375                 380                 


Asn Leu Ala Ile Ser Gln Val Thr Thr Lys Tyr Val Leu Trp Val Asp 
385                 390                 395                 400 


Asp Asp Phe Leu Phe Asn Glu Glu Thr Lys Ile Glu Val Leu Val Asp 
                405                 410                 415     


Val Leu Glu Lys Thr Glu Leu Asp Val Val Gly Gly Ser Val Leu Gly 
            420                 425                 430         


Asn Val Phe Gln Phe Lys Leu Leu Leu Glu Gln Ser Glu Asn Gly Ala 
        435                 440                 445             


Cys Leu His Lys Arg Met Gly Phe Phe Gln Pro Leu Asp Gly Phe Pro 
    450                 455                 460                 


Ser Cys Val Val Thr Ser Gly Val Val Asn Phe Phe Leu Ala His Thr 
465                 470                 475                 480 


Glu Arg Leu Gln Arg Val Gly Phe Asp Pro Arg Leu Gln Arg Val Ala 
                485                 490                 495     


His Ser Glu Phe Phe Ile Asp Gly Leu Gly Thr Leu Leu Val Gly Ser 
            500                 505                 510         


Cys Pro Glu Val Ile Ile Gly His Gln Ser Arg Ser Pro Val Val Asp 
        515                 520                 525             


Ser Glu Leu Ala Ala Leu Glu Lys Thr Tyr Asn Thr Tyr Arg Ser Asn 
    530                 535                 540                 


Thr Leu Thr Arg Val Gln Phe Lys Leu Ala Leu His Tyr Phe Lys Asn 
545                 550                 555                 560 


His Leu Gln Cys Ala Ala 
                565     


<210>  3544
<211>  1039
<212>  DNA
<213>  Homosapiens

<400>  3544
tgaagagtga gctaggagaa cttcgtaagg tgaaactgtg gggatccaat gggcaacaca     60

aagcatcttg gttaaggagg ttaggggccg gtctaggact tgcctcagga ggaaggacag    120

cctcagagca tgctcagagg tgggaaggga aggaggagaa agcaggcgaa gcggggccat    180

ctgctttatc tgaagatttt cagctgatga agaactagga ggctcaaaca ctacttacct    240

gagtccagga caagtgactt ggagagtgtg ctcttctgtg gcaggatcag gtctgtctag    300

ggcaggatgg cccaggatct cagcgagaag gacctgttga agatggaggt ggagcagctg    360

aagaaagaag tgaaaaacac aagaattccg atttccaaag cgggaaagga aatcaaggag    420

tacgtggagg cccaagcagg aaacgatcct tttctcaaag gcatccctga ggacaagaat    480

cccttcaagg agaaaggtgg ctgtctgata agctgatggc atggagccct gccctgagtg    540

tctgtccctc ttcagccaag cccaagtctc ctagaccccc agggagccag tgaactgtca    600

ccttctcttc atcacagaat gagtaaagat ccctgaacaa atgcattgtg aacccattcc    660

ccactcccac cttcaactct tttctcccat tatttcctcc acctgctggg tctctgctga    720

ccttgctggg aacactctga ggacagtgtg gctggccgag cggttggccc catgggtggt    780

ggggtgtgag aagcctgcaa taccccaaga ccccagaggg cagtccttag gaagcactta    840

caccacctgg gaacccctcc gtcttttccc tctactctca tcctaggaat aaagcatttc    900

cacgccagag tagtttgggc tgggggccag ggttgggtgg gtcctgtccc tccatatcat    960

gtcctaccct atggtcctgt tcctagtcat ttagatcacc ccagatggcc tgatgacaac   1020

aagagtttgt gaagttatg                                                1039


<210>  3545
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  3545

Met Ala Gln Asp Leu Ser Glu Lys Asp Leu Leu Lys Met Glu Val Glu 
1               5                   10                  15      


Gln Leu Lys Lys Glu Val Lys Asn Thr Arg Ile Pro Ile Ser Lys Ala 
            20                  25                  30          


Gly Lys Glu Ile Lys Glu Tyr Val Glu Ala Gln Ala Gly Asn Asp Pro 
        35                  40                  45              


Phe Leu Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe Lys Glu Lys Gly 
    50                  55                  60                  


Gly Cys Leu Ile Ser 
65                  


<210>  3546
<211>  2129
<212>  DNA
<213>  Homosapiens

<400>  3546
tcctatccac cctccactcc cctgtccctt ggtgactcat ccctgagctt cccaaggaag     60

cccccaccct ctgccctttc ctcccgcctt ccatgagtgg aaaatccacc tccgccccct    120

atagcaggcc agcccccttc ctccccagtc tccgacccca tcccccagcc gaccagtttc    180

ctctccagga ccagggagca atcacagctg ccccgacctt ggcttcctct gctgggtggg    240

attgggggct gggcccccaa atgggcccct ggcttccccc ttcctctggg caggggacag    300

agagacacag gctcggggag caggactgac ttcctcttgt cccggaatga gcatgcctgc    360

cctttgcaag caggtttggg tctcacgcag aggaaaccaa aagcaataag agggagggaa    420

ggcagagcaa ccaatcaagg gcagggtgag actcaaaacg agcgggctcc ctggggagcc    480

agacagaggc tgggggtgat ggcggagcta cagcagctgc aggagtttga gatccccact    540

ggccgggagg ctctgagggg caaccacagt gccctgctgc gggtcgctga ctactgcgag    600

gacaactatg tgcaggccac agacaagcgg aaggcgctgg aggagaccat ggccttcact    660

acccaggcac tggccagcgt ggcctaccag gtgggcaacc tggccgggca cactctgcgc    720

atgttggacc tgcagggggc cgccctgcgg caggtggaag cccgtgtaag cacgctgggc    780

cagatggtga acatgcatat ggagaaggtg gcccgaaggg agatcggcac cttagccact    840

gtccagcggc tgccccccgg ccagaaggtc atcgccccag agaacctacc ccctctcacg    900

ccctactgca ggagacccct caactttggc tgcctggacg acattggcca tgggatcaag    960

gacctcagca cgcagctgtc aagaacaggc accctgtctc gaaagagcat caaggcccct   1020

gccacacccg cctccgccac cttggggaga ccaccccgga ttcccgagcc agtgcacctg   1080

ccggtggtgc ccgacggcag actctccgcc gcctcctctg cgtcttccct ggcctcggcc   1140

ggcagcgccg aaggtgtcgg tggggccccc acgcccaagg ggcaggcagc acctccagcc   1200

ccacctctcc ccagctcctt ggacccacct cctccaccag cagccgtcga ggtgttccag   1260

cggcctccca cgctggagga gttgtcccca cccccaccgg acgaagagct gcccctgcca   1320

ctggacctgc ctcctcctcc acccctggat ggagatgaat tggggctgcc tccaccccca   1380

ccaggatttg ggcctgatga gcccagctgg gtgcctgcct catacttgga gaaagtggtg   1440

acactgtacc catacaccag ccagaaggac aatgagctct ccttctctga gggcactgtc   1500

atctgtgtca ctcgccgcta ctccgatggc tggtgcgagg gcgtcagctc agaggggact   1560

ggattcttcc ctgggaacta tgtggagccc agctgctgac agcccagggc tctctgggca   1620

gctgatgtct gcactgagtg ggtttcatga gccccaagcc aaaaccagct ccagtcacag   1680

ctggactggg tctgcccacc tcttgggctg tgagctgtgt tctgtccttc ctcccatcgg   1740

agggagaagg ggtcctgggg agagagaatt tatccagagg cctgctgcag atggggaaga   1800

gctggaaacc aagaagtttg tcaacagagg acccctactc catgcaggac agggtctcct   1860

gctgcaagtc ccaactttga ataaaacaga tgatgtcctg tgactgcccc acagagataa   1920

ggggccagga gggattgaaa ggcatcccag ttctaaggct gctgctaatt acagccccca   1980

acctccaacc caccagctga cctagaagca gcatcttccc atttcctcag tacccacaaa   2040

gtgcagccca cattggaccc cagacacccc tctgcagcca ttgactgcaa cttgttcttt   2100

tgcccattga aaaaaaaaaa aaaaaaaaa                                     2129


<210>  3547
<211>  366
<212>  PRT
<213>  Homosapiens

<400>  3547

Met Ala Glu Leu Gln Gln Leu Gln Glu Phe Glu Ile Pro Thr Gly Arg 
1               5                   10                  15      


Glu Ala Leu Arg Gly Asn His Ser Ala Leu Leu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asp Asn Tyr Val Gln Ala Thr Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Thr Met Ala Phe Thr Thr Gln Ala Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Val Gly Asn Leu Ala Gly His Thr Leu Arg Met Leu Asp Leu Gln Gly 
65                  70                  75                  80  


Ala Ala Leu Arg Gln Val Glu Ala Arg Val Ser Thr Leu Gly Gln Met 
                85                  90                  95      


Val Asn Met His Met Glu Lys Val Ala Arg Arg Glu Ile Gly Thr Leu 
            100                 105                 110         


Ala Thr Val Gln Arg Leu Pro Pro Gly Gln Lys Val Ile Ala Pro Glu 
        115                 120                 125             


Asn Leu Pro Pro Leu Thr Pro Tyr Cys Arg Arg Pro Leu Asn Phe Gly 
    130                 135                 140                 


Cys Leu Asp Asp Ile Gly His Gly Ile Lys Asp Leu Ser Thr Gln Leu 
145                 150                 155                 160 


Ser Arg Thr Gly Thr Leu Ser Arg Lys Ser Ile Lys Ala Pro Ala Thr 
                165                 170                 175     


Pro Ala Ser Ala Thr Leu Gly Arg Pro Pro Arg Ile Pro Glu Pro Val 
            180                 185                 190         


His Leu Pro Val Val Pro Asp Gly Arg Leu Ser Ala Ala Ser Ser Ala 
        195                 200                 205             


Ser Ser Leu Ala Ser Ala Gly Ser Ala Glu Gly Val Gly Gly Ala Pro 
    210                 215                 220                 


Thr Pro Lys Gly Gln Ala Ala Pro Pro Ala Pro Pro Leu Pro Ser Ser 
225                 230                 235                 240 


Leu Asp Pro Pro Pro Pro Pro Ala Ala Val Glu Val Phe Gln Arg Pro 
                245                 250                 255     


Pro Thr Leu Glu Glu Leu Ser Pro Pro Pro Pro Asp Glu Glu Leu Pro 
            260                 265                 270         


Leu Pro Leu Asp Leu Pro Pro Pro Pro Pro Leu Asp Gly Asp Glu Leu 
        275                 280                 285             


Gly Leu Pro Pro Pro Pro Pro Gly Phe Gly Pro Asp Glu Pro Ser Trp 
    290                 295                 300                 


Val Pro Ala Ser Tyr Leu Glu Lys Val Val Thr Leu Tyr Pro Tyr Thr 
305                 310                 315                 320 


Ser Gln Lys Asp Asn Glu Leu Ser Phe Ser Glu Gly Thr Val Ile Cys 
                325                 330                 335     


Val Thr Arg Arg Tyr Ser Asp Gly Trp Cys Glu Gly Val Ser Ser Glu 
            340                 345                 350         


Gly Thr Gly Phe Phe Pro Gly Asn Tyr Val Glu Pro Ser Cys 
        355                 360                 365     


<210>  3548
<211>  2070
<212>  DNA
<213>  Homosapiens

<400>  3548
gcggctccgg ctccggctcc ggctcccggg catttaaagg ggacgcggcg gctgcccggg     60

ggggatgagg ggcaagtgga ggggacggct cagacgcaca tcatcctcag tccctcggga    120

ctggagggac tcgtgagccg gagcccagaa atccgggggt ggataagaca ccgcgtcccc    180

tccaattccc gtaagcaccc cttgctccat cctgcgcccc aatacctcag ctagccccct    240

tccccacttc ttacactcca aactcagccg ggacagcaag tggaggggac ggctcagacg    300

acctctgctg ccgccgcccc cacgaacgtg tgacgacggc tggaggccaa cagagtccct    360

acaggtggtg ctcacggtaa tgcaccgaca atgagtggct gttttccagt ttctggcctc    420

cgctgcctat ctagggacgg caggatggcc gcgcagggcg cgccgcgctt cctcctgacc    480

ttcgacttcg acgagactat cgtggacgaa aacagcgacg attcgatcgt gcgcgccgcg    540

ccgggccagc ggctcccgga gagcctgcga gccacctacc gcgagggctt ctacaacgag    600

tacatgcagc gcgtcttcaa gtacctgggc gagcagggcg tgcggccgcg ggacctgagc    660

gccatctacg aagccatccc tttgtcgcca ggcatgagcg acctgctgca gtttgtggca    720

aaacagggcg cctgcttcga ggtgattctc atctccgatg ccaacacctt tggcgtggag    780

agctcgctgc gcgccgccgg ccaccacagc ctgttccgcc gcatcctcag caacccgtcg    840

gggccggatg cgcggggact gctggctctg cggccgttcc acacacacag ctgcgcgcgc    900

tgccccgcca acatgtgcaa gcacaaggtg ctcagcgact acctgcgcga gcgggcccac    960

gacggcgtgc acttcgagcg cctcttctac gtgggcgacg gcgccaacga cttctgcccc   1020

atggggctgc tggcgggcgg cgacgtggcc ttcccgcgcc gcggctaccc catgcaccgc   1080

ctcattcagg aggcccagaa ggccgagccc agctcgttcc gcgccagcgt ggtgccctgg   1140

gaaacggctg cagatgtgcg cctccacctg caacaggtgc tgaagtcgtg ctgagtctgg   1200

ccgcctgcag gggggtaccc gggccaacgg cggagggggc ggggaaggga gattcggcaa   1260

agacagcttt actactccct tttccctttg gctttgttat gtccctctgg gaatttctgg   1320

aatctcgtat ttgggggctt ggggaagggg gctcagagcc gtccctatct attcagttaa   1380

cccacctcgg ctgcctcccc cactccactg tgcacggttg agttctggag tctgacccat   1440

cgcggggtgg cgcgcaaacc ttggaaggca gcagtatttc ctggtcctcc caactgggag   1500

gaaggggccc ccccggcagg tgagagaagg aacatctccc gccgctgtaa cttgttgcct   1560

cgggctgcgt gaccgcccct cctccagtct actgtggagg gaacccagga tcctgaaatt   1620

ctcctggccg caagaactcc ccacagaggc agaagagggt ctccacctat ggccccaggc   1680

ctttgcgatc ttgcttcacc caccgcgacc ccacactatt tctgtgctgt ccacactctc   1740

ttgcctcccg acccccgcac tcccttctag cacccccaaa ggaaaagcca gaggaacaat   1800

cgcctcctgg tggtggtacg aggtagcgca ccgtccggct cgggtccgga cagccagtaa   1860

cctcgcagag agtgacggtg tctccttgca tcccagcctc gtctatgcag caagagacca   1920

gggacttcac caaagtcacc ctcgcgggct gggccttcca cgcatccccc ccacccccca   1980

tggaacagaa agccatgttt ttaagcagaa ccagcgaaac ccaagcccct ccttcctctg   2040

gtgttttaca actataaagg aggtgaaggg                                    2070


<210>  3549
<211>  267
<212>  PRT
<213>  Homosapiens

<400>  3549

Met Ser Gly Cys Phe Pro Val Ser Gly Leu Arg Cys Leu Ser Arg Asp 
1               5                   10                  15      


Gly Arg Met Ala Ala Gln Gly Ala Pro Arg Phe Leu Leu Thr Phe Asp 
            20                  25                  30          


Phe Asp Glu Thr Ile Val Asp Glu Asn Ser Asp Asp Ser Ile Val Arg 
        35                  40                  45              


Ala Ala Pro Gly Gln Arg Leu Pro Glu Ser Leu Arg Ala Thr Tyr Arg 
    50                  55                  60                  


Glu Gly Phe Tyr Asn Glu Tyr Met Gln Arg Val Phe Lys Tyr Leu Gly 
65                  70                  75                  80  


Glu Gln Gly Val Arg Pro Arg Asp Leu Ser Ala Ile Tyr Glu Ala Ile 
                85                  90                  95      


Pro Leu Ser Pro Gly Met Ser Asp Leu Leu Gln Phe Val Ala Lys Gln 
            100                 105                 110         


Gly Ala Cys Phe Glu Val Ile Leu Ile Ser Asp Ala Asn Thr Phe Gly 
        115                 120                 125             


Val Glu Ser Ser Leu Arg Ala Ala Gly His His Ser Leu Phe Arg Arg 
    130                 135                 140                 


Ile Leu Ser Asn Pro Ser Gly Pro Asp Ala Arg Gly Leu Leu Ala Leu 
145                 150                 155                 160 


Arg Pro Phe His Thr His Ser Cys Ala Arg Cys Pro Ala Asn Met Cys 
                165                 170                 175     


Lys His Lys Val Leu Ser Asp Tyr Leu Arg Glu Arg Ala His Asp Gly 
            180                 185                 190         


Val His Phe Glu Arg Leu Phe Tyr Val Gly Asp Gly Ala Asn Asp Phe 
        195                 200                 205             


Cys Pro Met Gly Leu Leu Ala Gly Gly Asp Val Ala Phe Pro Arg Arg 
    210                 215                 220                 


Gly Tyr Pro Met His Arg Leu Ile Gln Glu Ala Gln Lys Ala Glu Pro 
225                 230                 235                 240 


Ser Ser Phe Arg Ala Ser Val Val Pro Trp Glu Thr Ala Ala Asp Val 
                245                 250                 255     


Arg Leu His Leu Gln Gln Val Leu Lys Ser Cys 
            260                 265         


<210>  3550
<211>  2317
<212>  DNA
<213>  Homosapiens

<400>  3550
agttaggtga agaggagaac gatgtccagg caggggccgg ggaagcccgt gccaaggcac     60

tgaggggaag tgctgcaatg aacctcagag gctggatctt gctgactcat ctggggtacc    120

aagggcagac aaaggacatg gagtccaggc ccaggaggcg ataccaggcc agcagtttca    180

ctgatgctcc tgtcatgacg atgactgcct ccctcctccc cttggtccct gactcagtgt    240

ctgcagtgac caggcaccag gcagggagca aggaaccaag cctttcacct gctcccacca    300

actcctatgg tgctcccttt ccaaggctag gtctcctctc cacccagttc cttatcacgt    360

accatgagaa gctgtcacct tggcaactgt caccttctgg tgagatttac aattgcactg    420

ctacaactgc ttgtggcatg gtaaagttgc accaggacct ctgctgtcca tgagatcaaa    480

gttccaggcc aaggcaccag gggcacgaac agtgttgccc gcatggaact cacacttaat    540

gggagcggca gccaacagag tcttgctgtg tcacccaggc cggagtgcac tagcacaatc    600

tcagctcatt gcaacctcca tctcccaggt tcaagtgatt ctcctgcctc agcctcccga    660

gtagctggga ttacaggcct gtgccactat gctaattttt tttttttgta ttattagtag    720

agacagggtt tcaccatgtt agccaggccg gtcttgaact tctgacctca agtgatctgc    780

ccacctcggc ctcccaaagt gctgggatta caggtgtgag ccaccgctcc tggctgaggc    840

cacctctttt cttggggaca cttgggctcc agctttctcc attcatcagc ttagcatgag    900

cttgaggaac gcagaggggg gctgactgag aggagcaggc actggggaca atggggacat    960

ccacggttcc tagcaatgga tttgaggtgg gatttccaat tcctcttctc ccaccttgga   1020

tttgaccatc tgaataccaa attcctgtca cttctaggat gtcacctaag atgagactgt   1080

ggtctttcca ctcttgggtc ccaaggaggt gccacagggc ctacaataag gcaaggaagg   1140

ctcagtgagg tccgtgttca ccccaccccc acttcaacac gaggagttct gcttttattt   1200

tgcctctgtg tgtgtgtgtg tgtgtgtgtg tttctaggta ttattttatt tggagaaagg   1260

atttgctcct aaggacacac acacgcacac acacatgcac actcacgcac acgtactcac   1320

aggttctgca aaacactagt gtggcagaaa gtgttgaaaa ctagttctag acctggcatg   1380

aatttgacca ggttcagcct tagtctcctc tcttagaaat aaggtcatct gggccaggtg   1440

cggtggctca agcctgtaat cccagcactt tgggaggccg aggtgggcgg atcacgagat   1500

caggacctca agaccagcct gaccaacatg gtgaaacccc gtctctacta aaaatacaaa   1560

aattagccag gcatggtggc acgtgcctat aatcccagct agtctggagg gtgaggcagg   1620

agaatcgctg gaacctggga ggcagaggtt gcggcgagcc gagatcatgt ggggaaataa   1680

ggccatctgg aaatatcctt cccatcacag gatgataccc ggcaaattct tcaaagcagt   1740

gttctccaac ttgaatgttt gtgatgtggg cgattctgac tgagggggtc tgtagaccac   1800

atcttgataa acaatgcttt ttaaaaaatt cctagaagag aatatttgat ttctggaagg   1860

atagagaaga aactaataag agtgtttacc tccgaggagg aggagaattg ggaagctgag   1920

agcagaggag ggaggaagac ttacttttca ccgtgttctt ttttgtacct tttgagtttt   1980

gtacgacata ctgaatcttt gacccatttg caattataaa taaaggcaca tttatttggc   2040

cgggcgcggt ggctcatgcc tgtaatccca gcactttggg aggacgaggt gggtggatca   2100

cctaaggtca ggagttagtg accagcctgg ccaacatggt gaaacctcgc tctactaaaa   2160

cacaaaaatt agccagatgt ggtggcaggc acctgtaatc ccagctactc agaaggctga   2220

ggcaggagaa tcgcttgaac ctgggaggca gaggttgcag tgagctgaga tcgcacgact   2280

gcactccagc ctgggcaaca gagtgagact ctgtctc                            2317


<210>  3551
<211>  131
<212>  PRT
<213>  Homosapiens

<400>  3551

Met Asn Leu Arg Gly Trp Ile Leu Leu Thr His Leu Gly Tyr Gln Gly 
1               5                   10                  15      


Gln Thr Lys Asp Met Glu Ser Arg Pro Arg Arg Arg Tyr Gln Ala Ser 
            20                  25                  30          


Ser Phe Thr Asp Ala Pro Val Met Thr Met Thr Ala Ser Leu Leu Pro 
        35                  40                  45              


Leu Val Pro Asp Ser Val Ser Ala Val Thr Arg His Gln Ala Gly Ser 
    50                  55                  60                  


Lys Glu Pro Ser Leu Ser Pro Ala Pro Thr Asn Ser Tyr Gly Ala Pro 
65                  70                  75                  80  


Phe Pro Arg Leu Gly Leu Leu Ser Thr Gln Phe Leu Ile Thr Tyr His 
                85                  90                  95      


Glu Lys Leu Ser Pro Trp Gln Leu Ser Pro Ser Gly Glu Ile Tyr Asn 
            100                 105                 110         


Cys Thr Ala Thr Thr Ala Cys Gly Met Val Lys Leu His Gln Asp Leu 
        115                 120                 125             


Cys Cys Pro 
    130     


<210>  3552
<211>  1879
<212>  DNA
<213>  Homosapiens

<400>  3552
agttccaagt ttggagcttt tagctgccag ccctggccca tcatgtagct gcagcacagc     60

cttccctaac gttgcaactg ggggaaaaat cactttccag tctgttttgc aaggtgtgca    120

tttccatctt gattccctga aagtccatct gctgcatcgg tcaagagaaa ctccacttgc    180

atgaagattg cacgcctgca gcttgcatct ttgttgcaaa actagctaca gaagagaagc    240

aaggcaaagt cttttgtgct cccctccccc atcaaaggaa aggggaaaat gtctcagtcg    300

aaaggcaaga agcgaaaccc tggccttaaa attccaaaag aagcatttga acaacctcag    360

accagttcca caccacctcg agatttagac tccaaggctt gcatttctat tggaaatcag    420

aactttgagg tgaaggcaga tgacctggag cctataatgg aactgggacg aggtgcgtac    480

ggggtggtgg agaagatgcg gcacgtgccc agcgggcaga tcatggcagt gaagcggatc    540

cgagccacag taaatagcca ggaacagaaa cggctactga tggatttgga tatttccatg    600

aggacggtgg actgtccatt cactgtcacc ttttatggcg cactgtttcg ggagggtgat    660

gtgtggatct gcatggagct catggataca tcactagata aattctacaa acaagttatt    720

gataaaggcc agacaattcc agaggacatc ttagggaaaa tagcagtttc tattgtaaaa    780

gcattagaac atttacatag taagctgtct gtcattcaca gagacgtcaa gccttctaat    840

gtactcatca atgctctcgg tcaagtgaag atgtgcgatt ttggaatcag tggctacttg    900

gtggactctg ttgctaaaac aattgatgca ggttgcaaac catacatggc ccctgaaaga    960

ataaacccag agctcaacca gaagggatac agtgtgaagt ctgacatttg gagtctgggc   1020

atcacgatga ttgagttggc catccttcga tttccctatg attcatgggg aactccattt   1080

cagcagctca aacaggtggt agaggagcca tcgccacaac tcccagcaga caagttctct   1140

gcagagtttg ttgactttac ctcacagtgc ttaaagaaga attccaaaga acggcctaca   1200

tacccagagc taatgcaaca tccatttttc accctacatg aatccaaagg aacagatgtg   1260

gcatcttttg taaaactgat tcttggagac taaaaagcag tggacttaat cggttgaccc   1320

tactgtggat tggtgggttt cggggtgaag caagttcact acagcatcaa tagaaagtca   1380

tctttgagat aatttaaccc tgcctctcag agggttttct ctcccaattt tctttttact   1440

ccccctctta agggggcctt ggaatctata gtatagaatg aactgtctag atggatgaat   1500

tatgataaag gcttaggact tcaaaaggtg attaaatatt taatgatgtg tcatatgagt   1560

cctcaagctt ctcagacttc tcttattctt tacaaaatga atgcattggc cctgacaaaa   1620

aggtgctacg gtagtgatga aattataagt agatttgtag tttgtcccat ttattatttt   1680

aatatttatg tttaagtgct tggttgaaaa gattccattt tatacaagaa gggagattca   1740

aaaaaaaaat ataaggttgg gttagcaata tttatagggc ttttattttt taagttcaat   1800

tgtgtctgtg gtccagaaga aattatttaa tatgcatctt tgagaatatt ataaaaatat   1860

caaaaaggaa aaaaaaaaa                                                1879


<210>  3553
<211>  334
<212>  PRT
<213>  Homosapiens

<400>  3553

Met Ser Gln Ser Lys Gly Lys Lys Arg Asn Pro Gly Leu Lys Ile Pro 
1               5                   10                  15      


Lys Glu Ala Phe Glu Gln Pro Gln Thr Ser Ser Thr Pro Pro Arg Asp 
            20                  25                  30          


Leu Asp Ser Lys Ala Cys Ile Ser Ile Gly Asn Gln Asn Phe Glu Val 
        35                  40                  45              


Lys Ala Asp Asp Leu Glu Pro Ile Met Glu Leu Gly Arg Gly Ala Tyr 
    50                  55                  60                  


Gly Val Val Glu Lys Met Arg His Val Pro Ser Gly Gln Ile Met Ala 
65                  70                  75                  80  


Val Lys Arg Ile Arg Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu 
                85                  90                  95      


Leu Met Asp Leu Asp Ile Ser Met Arg Thr Val Asp Cys Pro Phe Thr 
            100                 105                 110         


Val Thr Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys 
        115                 120                 125             


Met Glu Leu Met Asp Thr Ser Leu Asp Lys Phe Tyr Lys Gln Val Ile 
    130                 135                 140                 


Asp Lys Gly Gln Thr Ile Pro Glu Asp Ile Leu Gly Lys Ile Ala Val 
145                 150                 155                 160 


Ser Ile Val Lys Ala Leu Glu His Leu His Ser Lys Leu Ser Val Ile 
                165                 170                 175     


His Arg Asp Val Lys Pro Ser Asn Val Leu Ile Asn Ala Leu Gly Gln 
            180                 185                 190         


Val Lys Met Cys Asp Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val 
        195                 200                 205             


Ala Lys Thr Ile Asp Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg 
    210                 215                 220                 


Ile Asn Pro Glu Leu Asn Gln Lys Gly Tyr Ser Val Lys Ser Asp Ile 
225                 230                 235                 240 


Trp Ser Leu Gly Ile Thr Met Ile Glu Leu Ala Ile Leu Arg Phe Pro 
                245                 250                 255     


Tyr Asp Ser Trp Gly Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu 
            260                 265                 270         


Glu Pro Ser Pro Gln Leu Pro Ala Asp Lys Phe Ser Ala Glu Phe Val 
        275                 280                 285             


Asp Phe Thr Ser Gln Cys Leu Lys Lys Asn Ser Lys Glu Arg Pro Thr 
    290                 295                 300                 


Tyr Pro Glu Leu Met Gln His Pro Phe Phe Thr Leu His Glu Ser Lys 
305                 310                 315                 320 


Gly Thr Asp Val Ala Ser Phe Val Lys Leu Ile Leu Gly Asp 
                325                 330                 


<210>  3554
<211>  201
<212>  DNA
<213>  Homosapiens

<400>  3554
atgatgctgc tgttctaccc tggctgcagg gatgggctga tcgtggagga gggacagcgc     60

tgccgctgcc actccctcgc ctgcaacacg tgcctctgtg tgcacttcac ccacaagctt    120

cagacccact ctgcagatga gccgaagacc accttctacc agtgctgcag gactcagtgt    180

ggacaccact ggagggatta g                                              201


<210>  3555
<211>  66
<212>  PRT
<213>  Homosapiens

<400>  3555

Met Met Leu Leu Phe Tyr Pro Gly Cys Arg Asp Gly Leu Ile Val Glu 
1               5                   10                  15      


Glu Gly Gln Arg Cys Arg Cys His Ser Leu Ala Cys Asn Thr Cys Leu 
            20                  25                  30          


Cys Val His Phe Thr His Lys Leu Gln Thr His Ser Ala Asp Glu Pro 
        35                  40                  45              


Lys Thr Thr Phe Tyr Gln Cys Cys Arg Thr Gln Cys Gly His His Trp 
    50                  55                  60                  


Arg Asp 
65      


<210>  3556
<211>  2996
<212>  DNA
<213>  Homosapiens

<400>  3556
cgcagccacc catgcgcgcg cgctcgcaag accaccagcg cccagagccc cagtctgagg     60

cttggcgccg ggggtctgcg ggcgagggga gctctctacg tgcgaggggc tagcgggagc    120

cggcacaaga gggtcgagga gccaggaacc ccaaacgtcc ggcgccaggc gctagccaag    180

ctgctgcgcg ccccggcgcc cagctggctc ggggacagcc gctgggtgtc ggagaccgga    240

gctagcggat tgcagcggaa aagcaaagat gtcacactgg atccttggcc tccagggtcc    300

attaaggtga gaataagatc tctgggctgg ctggaactag cctaagactg aaaagcagcc    360

atggacatgg cggatgagcc actcaatgga agccacacat ggctatccat tccatttgac    420

ctcaatggct ctgtggtgtc aaccaacacc tcaaaccaga cagagccgta ctatgacctg    480

acaagcaatg cagtcctcac attcatctat tttgtggtct gcatcattgg gttgtgtggc    540

aacacacttg tcatttatgt catcctccgc tatgccaaga tgaagaccat caccaacatt    600

tacatcctca acctggccat cgcagatgag ctcttcatgc tgggtctgcc tttcttggct    660

atgcaggtgg ctctggtcca ctggcccttt ggcaaggcca tttgccgggt ggtcatgact    720

gtggatggca tcaatcagtt caccagcatc ttctgcctga cagtcatgag catcgaccga    780

tacctggctg tggtccaccc catcaagtcg gccaagtgga ggagaccccg gacggccaag    840

atgatcacca tggctgtgtg gggagtctct ctgctggtca tcttgcccat catgatatat    900

gctgggctcc ggagcaacca gtgggggaga agcagctgca ccatcaactg gccaggtgaa    960

tctggggctt ggtacacagg gttcatcatc tacactttca ttctggggtt cctggtaccc   1020

ctcaccatca tctgtctttg ctacctgttc attatcatca aggtgaagtc ctctggaatc   1080

cgagtgggct cctctaagag gaagaagtct gagaagaagg tcacccgaat ggtgtccatc   1140

gtggtggctg tcttcatctt ctgctggctt cccttctaca tattcaacgt ttcttccgtc   1200

tccatggcca tcagccccac cccagccctt aaaggcatgt ttgactttgt ggtggtcctc   1260

acctatgcta acagctgtgc caaccctatc ctatatgcct tcttgtctga caacttcaag   1320

aagagcttcc agaatgtcct ctgcttggtc aaggtgagcg gcacagatga tggggagcgg   1380

agtgacagta agcaggacaa atcccggctg aatgagacca cggagaccca gaggaccctc   1440

ctcaatggag acctccaaac cagtatctga actgcttggg gggtgggaaa gaaccaagcc   1500

atgctctgtc tactggcaat gggctcccta cccacactgg cttcctgcct cccacccctc   1560

acacctggct tctagaatag aggattgctc agcatgagtc caattcagag aacggtgttt   1620

gagtcagctt gtctgattga atgataatgt gctaaattga ttacctcccc cttaaagcga   1680

acactgaaat gcaggtagac aattcaaagt ctggagaaga gggatcatgc ctggatatga   1740

tctttagaaa caacaaaaat agaaaaaaat aagtatctgt gtgtttgtgt attgaaaact   1800

caatatgtaa tcttgtgttt ttatatgtat acttgtatat tcctatttat tctctgtata   1860

ggcattacct acgttcctgt gtttacatac acaagtagca aattcgagta tgcatagtgt   1920

agatggacat ttgccacaac acactgcccg cagaaatgga cttaccgtga agccaataaa   1980

gttcaagctt cagggatctc tcttgcacgg gccttgccaa ggcccaggag ggacttgggc   2040

agtatgttca tgtggtcata tgtttttgta aaaaattgtg aaagtaagat atgtttgtat   2100

tgtttttctt aaagaggaac ctcgtataag cttcaagcct cacaaacctt ctagcctctg   2160

cccttgggga tttgcttcat taatttcagg caagtgaggt caatgtaaga agggaaaggg   2220

agaagatatt tgaagaacca gaatgtaaat tcatgtgttt ccacttctca gatatagtca   2280

gagaattatt catttgccca aaaggactta agtggttgtg gtcatccatc attgtattta   2340

tcaagacaaa gccaactttg ttataagatt gcattttttt cttttcaaat tgctttagtt   2400

tttcttaggg agctatgagg gggaaaaatc actaacatga aaggcaaaaa atggactatg   2460

attcctgtgg ggaaacaatt tcattctctc catcgtgaaa ataagtgaat aagagtgaag   2520

caaaattaca cctttatgag aaaccataaa attgttttta tttttcaggc cagacatagc   2580

ttcctaatga aagaaaatgg aaatgtaatt cgacgactcc tcaaagggga ctttagagga   2640

cttcatacaa agctgggcat taagaaaacc acaatgcatg gccgggcgtg gtggcttaca   2700

cctgtaatcc cagcactttg ggaggccgag gtgggtggat cacccgaggt caggagttcg   2760

agaccagcct ggccaacatg gtgaaacccc atcactacta aaaatatgta aattagtcgg   2820

gcgtggtgtc acgtgcctgt aatcctagct gctcgggagg ctgaggcagg agaatcactt   2880

gaacttggga ggtggaggtt gcagtaagct gagattgtgc cactgcactc tagcctgagc   2940

aacaagagca aaactcagtc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa       2996


<210>  3557
<211>  369
<212>  PRT
<213>  Homosapiens

<400>  3557

Met Asp Met Ala Asp Glu Pro Leu Asn Gly Ser His Thr Trp Leu Ser 
1               5                   10                  15      


Ile Pro Phe Asp Leu Asn Gly Ser Val Val Ser Thr Asn Thr Ser Asn 
            20                  25                  30          


Gln Thr Glu Pro Tyr Tyr Asp Leu Thr Ser Asn Ala Val Leu Thr Phe 
        35                  40                  45              


Ile Tyr Phe Val Val Cys Ile Ile Gly Leu Cys Gly Asn Thr Leu Val 
    50                  55                  60                  


Ile Tyr Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ile Thr Asn Ile 
65                  70                  75                  80  


Tyr Ile Leu Asn Leu Ala Ile Ala Asp Glu Leu Phe Met Leu Gly Leu 
                85                  90                  95      


Pro Phe Leu Ala Met Gln Val Ala Leu Val His Trp Pro Phe Gly Lys 
            100                 105                 110         


Ala Ile Cys Arg Val Val Met Thr Val Asp Gly Ile Asn Gln Phe Thr 
        115                 120                 125             


Ser Ile Phe Cys Leu Thr Val Met Ser Ile Asp Arg Tyr Leu Ala Val 
    130                 135                 140                 


Val His Pro Ile Lys Ser Ala Lys Trp Arg Arg Pro Arg Thr Ala Lys 
145                 150                 155                 160 


Met Ile Thr Met Ala Val Trp Gly Val Ser Leu Leu Val Ile Leu Pro 
                165                 170                 175     


Ile Met Ile Tyr Ala Gly Leu Arg Ser Asn Gln Trp Gly Arg Ser Ser 
            180                 185                 190         


Cys Thr Ile Asn Trp Pro Gly Glu Ser Gly Ala Trp Tyr Thr Gly Phe 
        195                 200                 205             


Ile Ile Tyr Thr Phe Ile Leu Gly Phe Leu Val Pro Leu Thr Ile Ile 
    210                 215                 220                 


Cys Leu Cys Tyr Leu Phe Ile Ile Ile Lys Val Lys Ser Ser Gly Ile 
225                 230                 235                 240 


Arg Val Gly Ser Ser Lys Arg Lys Lys Ser Glu Lys Lys Val Thr Arg 
                245                 250                 255     


Met Val Ser Ile Val Val Ala Val Phe Ile Phe Cys Trp Leu Pro Phe 
            260                 265                 270         


Tyr Ile Phe Asn Val Ser Ser Val Ser Met Ala Ile Ser Pro Thr Pro 
        275                 280                 285             


Ala Leu Lys Gly Met Phe Asp Phe Val Val Val Leu Thr Tyr Ala Asn 
    290                 295                 300                 


Ser Cys Ala Asn Pro Ile Leu Tyr Ala Phe Leu Ser Asp Asn Phe Lys 
305                 310                 315                 320 


Lys Ser Phe Gln Asn Val Leu Cys Leu Val Lys Val Ser Gly Thr Asp 
                325                 330                 335     


Asp Gly Glu Arg Ser Asp Ser Lys Gln Asp Lys Ser Arg Leu Asn Glu 
            340                 345                 350         


Thr Thr Glu Thr Gln Arg Thr Leu Leu Asn Gly Asp Leu Gln Thr Ser 
        355                 360                 365             


Ile 
    


<210>  3558
<211>  3035
<212>  DNA
<213>  Homosapiens

<400>  3558
ggcgtaggta gatcgccggg ggctgacgag tgcaccatgg ccaccgcggc aacctcaccc     60

gcgctgaagc ggctggatct gcgcgaccct gcggctcttt tcgagacgca tggagcggag    120

gagatccgcg ggctggagcg ccaggttcgg gccgagatcg agcacaagaa ggaggagctg    180

cggcagatgg tgggcgaacg gtaccgcgac ctgatcgagg cggccgacac catcggccag    240

atgcgccgct gcgccgtggg gctagtggac gccgtgaagg ccaccgacca gtactgcgcc    300

cgcctccgcc aggccggctc ggccgcgccc cggccaccgc gggcccagca gccacagcag    360

ccatcccagg agaagttcta cagcatggct gcccagatca agctactctt agaaattccg    420

gagaagatct ggagctcgat ggaagcctct cagtgtctcc acgccacaca gctctacctg    480

ctctgctgcc acctccacag cctgctccag ctggattctt ctagttcccg atacagtccc    540

gtcctctccc ggtttcctat actcatccgg caggtggcag ccgccagcca cttccggtca    600

actattctgc atgaaagcaa gatgttgctc aaatgccaag gtgtgtctga ccaagctgtg    660

gccgaggccc tgtgctctat aatgctctta gaagagagtt ctcctcgcca agccctcaca    720

gacttcctgc tggccagaaa ggcaactatt cagaaacttc tcaaccagcc acaccatggt    780

gctggtatca aggctcagat ttgctcatta gtggagttgc tggccaccac tctgaagcaa    840

gctcatgccc ttttctacac tttgccagaa ggactgctgc cagatccagc cctgccatgt    900

ggcttgctct tctctactct ggagaccatc acaggccagc atcctgccgg aaagggcact    960

ggtgtcctgc aggaagagat gaaactctgc agctggttta aacacctgcc agcatccatc   1020

gtcgagttcc agccaacact ccgaaccctt gcacatccca tcagtcagga atacctgaaa   1080

gacacgctgc agaaatggat ccacatgtgt aatgaagaca ttaaaaatgg gatcaccaac   1140

ctgctcatgt acgtgaagag catgaagggt ctcgcgggaa tccgggacgc catgtgggag   1200

ttacttacca atgagtccac caatcacagc tgggatgtgc tatgtcggcg gcttctggag   1260

aagccgctct tgttctggga agatatgatg cagcaactgt tccttgaccg attacagact   1320

ctgacaaaag aaggctttga ctccatctcc agtagctcca aggagctctt ggtttcagct   1380

ttgcaggaac ttgaaagcag caccagcaac tccccttcaa ataagcacat ccactttgag   1440

tacaacatgt cgctcttcct ctggtctgag agtcctaatg acctgccttc cgatgcggcc   1500

tgggtcagcg tggcaaaccg gggtcagttt gccagtagcg gcctctccat gaaagcacaa   1560

gccatcagcc cttgtgtaca gaacttctgt tctgccctgg attctaagct gaaggttaaa   1620

ctagatgacc tcctggctta cctcccctct gatgactcat cactgcccaa ggacgtttct   1680

cccacacagg ccaagagttc tgcctttgac agatacgcag atgcggggac cgtgcaggag   1740

atgctgcgga ctcagtccgt ggcatgcatc aagcacatcg tggactgcat ccgggcagag   1800

ctacagagca ttgaagaggg tgtgcaaggg caacaggatg ccctcaacag tgccaagctg   1860

cactcagttc ttttcatggc cagactctgc cagtccctgg gagagctgtg cccccatctg   1920

aagcagtgca tcctgggaaa atcagagagc tcagagaaac cagcaaggga gtttagggct   1980

ctgagaaaac agggaaaggt gaaaactcag gaaatcattc ctacacaggc caagtggcaa   2040

gaggttaaag aagtactcct ccagcagagc gtgatgggct accaggtctg gagcagtgca   2100

gttgtgaaag ttttgattca tggattcacc cagtcattac ttctagatga tgctggctca   2160

gttctggcca cagccaccag ctgggatgag ctagaaattc aggaggaggc agagtctggc   2220

agcagtgtca catccaagat ccgactccct gcacagccgt cctggtatgt acagtccttc   2280

ctgtttagtt tatgccagga aattaatcgg gttggaggcc atgccttgcc aaaggtgaca   2340

ttacaggaga tgctgaaaag ctgtatggtt caagtagtag ctgcctatga gaaactctcc   2400

gaagaaaaac agattaagaa agaaggtgca tttccagtca cccagaaccg ggcgctgcag   2460

ctgctttatg atctgcgtta cctcaacatt gttctgacag ccaagggtga cgaggtgaag   2520

agtggccgga gcaagccaga ctccagaatt gagaaagtga ctgaccacct ggaagccctc   2580

attgatccat ttgacctgga cgttttcacg ccacacctca acagcaacct tcatcgcctg   2640

gtgcagcgaa cttctgttct gtttggattg gtgactggta cagagaatca gctcgccccc   2700

cggagcagta cgttcaactc ccaagaaccc cataacatcc tgccactggc atccagtcag   2760

atcaggtttg gacttctccc actgagcatg acaagcactc gaaaggctaa atcaaccaga   2820

aacatcgaaa caaaagctca ggttgtcccc ccggcacgct ccacagctgg tgacccgaca   2880

gttcctggct ccttgttcag acagcttgtc agtgaagaag acaacacgtc tgcaccttca   2940

ttattcaaac ttggctggct ctctagtatg actaagtaac atggcaacac atctgtctct   3000

ccctaaataa atactaccac attatttctt ctaaa                              3035


<210>  3559
<211>  980
<212>  PRT
<213>  Homosapiens

<400>  3559

Met Ala Thr Ala Ala Thr Ser Pro Ala Leu Lys Arg Leu Asp Leu Arg 
1               5                   10                  15      


Asp Pro Ala Ala Leu Phe Glu Thr His Gly Ala Glu Glu Ile Arg Gly 
            20                  25                  30          


Leu Glu Arg Gln Val Arg Ala Glu Ile Glu His Lys Lys Glu Glu Leu 
        35                  40                  45              


Arg Gln Met Val Gly Glu Arg Tyr Arg Asp Leu Ile Glu Ala Ala Asp 
    50                  55                  60                  


Thr Ile Gly Gln Met Arg Arg Cys Ala Val Gly Leu Val Asp Ala Val 
65                  70                  75                  80  


Lys Ala Thr Asp Gln Tyr Cys Ala Arg Leu Arg Gln Ala Gly Ser Ala 
                85                  90                  95      


Ala Pro Arg Pro Pro Arg Ala Gln Gln Pro Gln Gln Pro Ser Gln Glu 
            100                 105                 110         


Lys Phe Tyr Ser Met Ala Ala Gln Ile Lys Leu Leu Leu Glu Ile Pro 
        115                 120                 125             


Glu Lys Ile Trp Ser Ser Met Glu Ala Ser Gln Cys Leu His Ala Thr 
    130                 135                 140                 


Gln Leu Tyr Leu Leu Cys Cys His Leu His Ser Leu Leu Gln Leu Asp 
145                 150                 155                 160 


Ser Ser Ser Ser Arg Tyr Ser Pro Val Leu Ser Arg Phe Pro Ile Leu 
                165                 170                 175     


Ile Arg Gln Val Ala Ala Ala Ser His Phe Arg Ser Thr Ile Leu His 
            180                 185                 190         


Glu Ser Lys Met Leu Leu Lys Cys Gln Gly Val Ser Asp Gln Ala Val 
        195                 200                 205             


Ala Glu Ala Leu Cys Ser Ile Met Leu Leu Glu Glu Ser Ser Pro Arg 
    210                 215                 220                 


Gln Ala Leu Thr Asp Phe Leu Leu Ala Arg Lys Ala Thr Ile Gln Lys 
225                 230                 235                 240 


Leu Leu Asn Gln Pro His His Gly Ala Gly Ile Lys Ala Gln Ile Cys 
                245                 250                 255     


Ser Leu Val Glu Leu Leu Ala Thr Thr Leu Lys Gln Ala His Ala Leu 
            260                 265                 270         


Phe Tyr Thr Leu Pro Glu Gly Leu Leu Pro Asp Pro Ala Leu Pro Cys 
        275                 280                 285             


Gly Leu Leu Phe Ser Thr Leu Glu Thr Ile Thr Gly Gln His Pro Ala 
    290                 295                 300                 


Gly Lys Gly Thr Gly Val Leu Gln Glu Glu Met Lys Leu Cys Ser Trp 
305                 310                 315                 320 


Phe Lys His Leu Pro Ala Ser Ile Val Glu Phe Gln Pro Thr Leu Arg 
                325                 330                 335     


Thr Leu Ala His Pro Ile Ser Gln Glu Tyr Leu Lys Asp Thr Leu Gln 
            340                 345                 350         


Lys Trp Ile His Met Cys Asn Glu Asp Ile Lys Asn Gly Ile Thr Asn 
        355                 360                 365             


Leu Leu Met Tyr Val Lys Ser Met Lys Gly Leu Ala Gly Ile Arg Asp 
    370                 375                 380                 


Ala Met Trp Glu Leu Leu Thr Asn Glu Ser Thr Asn His Ser Trp Asp 
385                 390                 395                 400 


Val Leu Cys Arg Arg Leu Leu Glu Lys Pro Leu Leu Phe Trp Glu Asp 
                405                 410                 415     


Met Met Gln Gln Leu Phe Leu Asp Arg Leu Gln Thr Leu Thr Lys Glu 
            420                 425                 430         


Gly Phe Asp Ser Ile Ser Ser Ser Ser Lys Glu Leu Leu Val Ser Ala 
        435                 440                 445             


Leu Gln Glu Leu Glu Ser Ser Thr Ser Asn Ser Pro Ser Asn Lys His 
    450                 455                 460                 


Ile His Phe Glu Tyr Asn Met Ser Leu Phe Leu Trp Ser Glu Ser Pro 
465                 470                 475                 480 


Asn Asp Leu Pro Ser Asp Ala Ala Trp Val Ser Val Ala Asn Arg Gly 
                485                 490                 495     


Gln Phe Ala Ser Ser Gly Leu Ser Met Lys Ala Gln Ala Ile Ser Pro 
            500                 505                 510         


Cys Val Gln Asn Phe Cys Ser Ala Leu Asp Ser Lys Leu Lys Val Lys 
        515                 520                 525             


Leu Asp Asp Leu Leu Ala Tyr Leu Pro Ser Asp Asp Ser Ser Leu Pro 
    530                 535                 540                 


Lys Asp Val Ser Pro Thr Gln Ala Lys Ser Ser Ala Phe Asp Arg Tyr 
545                 550                 555                 560 


Ala Asp Ala Gly Thr Val Gln Glu Met Leu Arg Thr Gln Ser Val Ala 
                565                 570                 575     


Cys Ile Lys His Ile Val Asp Cys Ile Arg Ala Glu Leu Gln Ser Ile 
            580                 585                 590         


Glu Glu Gly Val Gln Gly Gln Gln Asp Ala Leu Asn Ser Ala Lys Leu 
        595                 600                 605             


His Ser Val Leu Phe Met Ala Arg Leu Cys Gln Ser Leu Gly Glu Leu 
    610                 615                 620                 


Cys Pro His Leu Lys Gln Cys Ile Leu Gly Lys Ser Glu Ser Ser Glu 
625                 630                 635                 640 


Lys Pro Ala Arg Glu Phe Arg Ala Leu Arg Lys Gln Gly Lys Val Lys 
                645                 650                 655     


Thr Gln Glu Ile Ile Pro Thr Gln Ala Lys Trp Gln Glu Val Lys Glu 
            660                 665                 670         


Val Leu Leu Gln Gln Ser Val Met Gly Tyr Gln Val Trp Ser Ser Ala 
        675                 680                 685             


Val Val Lys Val Leu Ile His Gly Phe Thr Gln Ser Leu Leu Leu Asp 
    690                 695                 700                 


Asp Ala Gly Ser Val Leu Ala Thr Ala Thr Ser Trp Asp Glu Leu Glu 
705                 710                 715                 720 


Ile Gln Glu Glu Ala Glu Ser Gly Ser Ser Val Thr Ser Lys Ile Arg 
                725                 730                 735     


Leu Pro Ala Gln Pro Ser Trp Tyr Val Gln Ser Phe Leu Phe Ser Leu 
            740                 745                 750         


Cys Gln Glu Ile Asn Arg Val Gly Gly His Ala Leu Pro Lys Val Thr 
        755                 760                 765             


Leu Gln Glu Met Leu Lys Ser Cys Met Val Gln Val Val Ala Ala Tyr 
    770                 775                 780                 


Glu Lys Leu Ser Glu Glu Lys Gln Ile Lys Lys Glu Gly Ala Phe Pro 
785                 790                 795                 800 


Val Thr Gln Asn Arg Ala Leu Gln Leu Leu Tyr Asp Leu Arg Tyr Leu 
                805                 810                 815     


Asn Ile Val Leu Thr Ala Lys Gly Asp Glu Val Lys Ser Gly Arg Ser 
            820                 825                 830         


Lys Pro Asp Ser Arg Ile Glu Lys Val Thr Asp His Leu Glu Ala Leu 
        835                 840                 845             


Ile Asp Pro Phe Asp Leu Asp Val Phe Thr Pro His Leu Asn Ser Asn 
    850                 855                 860                 


Leu His Arg Leu Val Gln Arg Thr Ser Val Leu Phe Gly Leu Val Thr 
865                 870                 875                 880 


Gly Thr Glu Asn Gln Leu Ala Pro Arg Ser Ser Thr Phe Asn Ser Gln 
                885                 890                 895     


Glu Pro His Asn Ile Leu Pro Leu Ala Ser Ser Gln Ile Arg Phe Gly 
            900                 905                 910         


Leu Leu Pro Leu Ser Met Thr Ser Thr Arg Lys Ala Lys Ser Thr Arg 
        915                 920                 925             


Asn Ile Glu Thr Lys Ala Gln Val Val Pro Pro Ala Arg Ser Thr Ala 
    930                 935                 940                 


Gly Asp Pro Thr Val Pro Gly Ser Leu Phe Arg Gln Leu Val Ser Glu 
945                 950                 955                 960 


Glu Asp Asn Thr Ser Ala Pro Ser Leu Phe Lys Leu Gly Trp Leu Ser 
                965                 970                 975     


Ser Met Thr Lys 
            980 


<210>  3560
<211>  2697
<212>  DNA
<213>  Homosapiens

<400>  3560
agtagtggtg gtacgggtcc gactgagggg tactcgccac cggctgcgtc cacccgagcg     60

gctgcgagag ccaaggcccg agggggtggg cgtggcggcc gccgaaacac aaccccctct    120

gttccctctc ttcgcggagc ggcgccgcgt agcttccatc cgccagctgc catgagcgag    180

cgcctccgtc ccaggaaaag gagaaggaat ggcaacgaag aagacaacca tcttcccccc    240

cagaccaaaa gaagtagcag aaaccctgtc tttcaggatt cctgggacac agagtcttca    300

ggcagtgaca gtggtgggag cagcagcagc agcagcagca gcatcaatag cccggacagg    360

gccagcgggc cggaaggcag cttgagccag accatggccg gatccagccc taacacgcct    420

cagcccgtgc ccgagcagtc cgcgctgtgc caaggcctct acttccacat caaccagacc    480

ctgagggagg cccacttcca cagcctacag caccgagggc ggcctctgac atgatgtgcc    540

ggcagtttct tgccttctgt gaagggacag cgctgtgcag atttgatatt tcaacttaca    600

acttgtttta aaagaaaaat tgcacacgaa aaatgcctgt tggcttttca gtctatattt    660

gaaataacag gttaacaggc agttgtttac ttgtggtttt gctgcactat tgcaatttca    720

aaggggcttt gaagcaattt tttataggat tcttttgagg gagggtatca aatctatgtc    780

aaggtagtgg tttgaggaaa actcattctg tgtgttgaat ccatagtatg tcccattcag    840

actgatttcc aaatctgtca actagaaact ctactttatg taaagggcct tttaaaaatg    900

cgggatcttc aatttttttt attcaataaa ctagtaaaga gtatctagtt tccatgaaaa    960

aacataagtt tttttccaaa atataggaag cttgattcag tcttgcactg aaattaactg   1020

ccatactacc tctcagtatg tagatgttct attgaaagta ctctctcctg tgtaacagga   1080

gaacaatcag atccaattca gactgtcagt gaagcacact ccctaataat agtctctact   1140

ctttgttata tatttgtatt tccagagaga atgtctttta gattcttgta tacccagata   1200

acttctgtgt cactattcca ccagagtctg cacctcagac tttagtagga aacatggcac   1260

agttctgcaa gtaaagtaat atgtaatgac tttttgtcct acaaacttgg tcagtcagca   1320

gcttacatga tctcattgac aattccacct tgtagtgtca acaattaagg tgttgttgaa   1380

cgctgataaa atgtaagcta cctgaactga tgtctaaagc aacaagtatt gtgaaatttt   1440

gggacaagga ttaacttgat gcttaaagta acccccaaca gtaactaggg ggccacattc   1500

catcagtgaa actggaaaga ttggtgtggc tgagaatcag atgagcagag gcacctttag   1560

aagaaataat gtggtagtat ttatttaggg agagacagat gtgttgccat gttacttagt   1620

catactagag agccagccaa gtttgaataa tgaaggtgca gacgtgttgt cttcttcact   1680

gacaagctgt ctgaacaagg agccaggaac tgtcgggtca ccagctgtgg agcgtgccgg   1740

ggggacaacc tgccattgga tgtagagaaa agtgccttag agttggcctg agccctcctg   1800

cccactcgcc ctccgcgcga cgccactcgg agtccacacg gcacacacaa gcggagctga   1860

gaagcacgat ggctctagtc agaggacttt gctgtcggtc cagatttgaa gaggacacgg   1920

aacagcatga gcctttgtga caaaactaga atttggaaat gaggactgtc ttgggaaaag   1980

ggtagacaca ggcacttctc tccacagcct gctaacctaa tgtgggcaga actgaaagat   2040

cactgcagtg gaaactgttc tggaagaggc tgcaacatag cccatgctta gggactggat   2100

ggtttttgca agagcttttt ttttttttaa actaccatct cccaactttt aaagccagat   2160

tcttgacaag gattttagat cttaatgggt tcgatggtag ggaatacgga aaggatacac   2220

tgctaatatt gtgtctaaca ataaagcaaa caactcgatg ctgtaagaag acaagctgtt   2280

tgagctttca aacacacatg cacacagcac aattcagaaa tacccaggag gattcctgca   2340

ggcttaacag ttggcatcgt actgaaatga aacgtgtatt aacaagaaaa tgtcaaactt   2400

ttggggaaac aaattttctg ttacttccca cccaactaaa agggaagata aaaccatcat   2460

caccagaaca aaacagattt tctccaaaca agtacaatga tagtgccggg ttggcagtta   2520

actctttcac cctactaaat tcaagagctc atctccaccc tgtcctgtat attttctaca   2580

tttctattaa gaggctactt ggtagtgtca gcgggcacct tttacacctt ctagtagctc   2640

aagctagtaa aaccttgtac ttctctattg cgccgccatt aaaagcagca ttagtgc      2697


<210>  3561
<211>  120
<212>  PRT
<213>  Homosapiens

<400>  3561

Met Ser Glu Arg Leu Arg Pro Arg Lys Arg Arg Arg Asn Gly Asn Glu 
1               5                   10                  15      


Glu Asp Asn His Leu Pro Pro Gln Thr Lys Arg Ser Ser Arg Asn Pro 
            20                  25                  30          


Val Phe Gln Asp Ser Trp Asp Thr Glu Ser Ser Gly Ser Asp Ser Gly 
        35                  40                  45              


Gly Ser Ser Ser Ser Ser Ser Ser Ser Ile Asn Ser Pro Asp Arg Ala 
    50                  55                  60                  


Ser Gly Pro Glu Gly Ser Leu Ser Gln Thr Met Ala Gly Ser Ser Pro 
65                  70                  75                  80  


Asn Thr Pro Gln Pro Val Pro Glu Gln Ser Ala Leu Cys Gln Gly Leu 
                85                  90                  95      


Tyr Phe His Ile Asn Gln Thr Leu Arg Glu Ala His Phe His Ser Leu 
            100                 105                 110         


Gln His Arg Gly Arg Pro Leu Thr 
        115                 120 


<210>  3562
<211>  2144
<212>  DNA
<213>  Homosapiens

<400>  3562
ggctgacatt cacgtttcat tctgccacac tcgggaacgg tgatcgggga agcatgggga     60

tccgggagaa gcacccacaa aactagcatc ctcctggagg agctcgggaa taggatgagt    120

gataatccac ccagaatgga agtgtgtcct tactgtaaga agccatttaa acgattaaaa    180

tcccacttgc catactgtaa gatgatagga ccaaccatac ctactgatca aaaagtttat    240

cagtccaagc cagctacact cccacgtgct aaaaagatga aaggaccaat caaagattta    300

attaaagcta aagggaaaga gttagagaca gagaatgaag aaagaaattc taagttggtg    360

gtggacaaac cagaacagac agtgaagacc tttccactgc cagctgttgg tttggaaaga    420

gcagctacta caaaggcaga taaagacatc aagaatccaa tccaaccatc cttcaaaatg    480

ttaaaaaata ctaaaccaat gactactttc caagaagaaa ccaaggctca gttttacgca    540

tcagagaaaa cctctcctaa aagagaactt gccaaagatt tgcctaaatc aggagaaagt    600

cgatgtaatc cttcagaagc tggagcgtct ttactggttg gctcaataga accttctttg    660

tcaaatcaag atagaaaata ttcctcaact ctacctaatg atgtacaaac tacctctggt    720

gatctcaaat tggacaaaat tgatccccaa agacaggaac ttctagtaaa attactagat    780

gtgcctactg gtgattgtca tatttctcca aagaatgtca gtgatggggt taaaagggta    840

agaacattat taagcaatga gagagattcc aaaggcaggg atcacctctc aggagtccct    900

actgatgtta cagttactga gactccagaa aagaacacag aatccctcat tttaagcctt    960

aaaatgagct cattaggtaa aatccaagtc atggagaaac aagagaaagg acttaccctg   1020

ggagtagaga cgtgtgggag caaaggaaat gcagagaaaa gtatgtctgc aacagaaaag   1080

caggaacgga ctgtcatgag ccatggctgt gagaacttca acaccaggga ttcagtcaca   1140

ggaaaggagt ctcaagggga aagaccacat ttaagtttgt tcattccgag ggagacgact   1200

taccagtttc attctgtatc gcagtcaagt agtcaaagtc ttgcctctct agctacaaca   1260

tttcttcaag aaaagaaagc agaagcccag aatcataatt gtgtccctga tgtaaaggca   1320

ttaatggaga gtcccgaggg acagttatct ctggagccca aatctgatag tcagttccaa   1380

gcatcacaca ctgggtgcca gagcccttta tgttcagccc agcgtcacac tcctcagagc   1440

cccttcacca atcatgctgc agctgctggc aggaagactc ttcgcagctg catggggctg   1500

gagtggtttc cagagctcta tcctggttac cttggactag gggtgttgcc agggaagcct   1560

cagtgttgga atgcaatgac ccagaagcca caacttatca gtccccaggg ggaaagactc   1620

tcacaagttt ctttgttgga acgaagctca actcatataa ggagtttgga accccctgcc   1680

ggacttacaa cctccaactt ctctctaatg aggctcttgg gagctgtaca aaaaggctgg   1740

atcaggtgca acaccaccat aaggaagagt ggattcggtg gcatcactat gctcttcaca   1800

ggatacttcg tcctgtgttg tagctggagt ttcagacgtc tgaaaaaatt gtgccgaccc   1860

ctgccctgga agagcacagt acctccatgc attggtgtgg cgaagacgac tggggattgc   1920

cgctctaaaa catgtttgga ttaggaagca cgtttaagta ggagaagcct tcgtgacttc   1980

tctctagtgc cttcgtgccc tgtgttgccc actgaattgc cctgtaacac ctaagtgtag   2040

tggtagcatt aagggatagc ttttcagccc tcaaggttat caggagcatt tgtatcactg   2100

ctataaataa agtagtatca cttgtcaaaa aaaaaaaaaa aaaa                    2144


<210>  3563
<211>  609
<212>  PRT
<213>  Homosapiens

<400>  3563

Met Ser Asp Asn Pro Pro Arg Met Glu Val Cys Pro Tyr Cys Lys Lys 
1               5                   10                  15      


Pro Phe Lys Arg Leu Lys Ser His Leu Pro Tyr Cys Lys Met Ile Gly 
            20                  25                  30          


Pro Thr Ile Pro Thr Asp Gln Lys Val Tyr Gln Ser Lys Pro Ala Thr 
        35                  40                  45              


Leu Pro Arg Ala Lys Lys Met Lys Gly Pro Ile Lys Asp Leu Ile Lys 
    50                  55                  60                  


Ala Lys Gly Lys Glu Leu Glu Thr Glu Asn Glu Glu Arg Asn Ser Lys 
65                  70                  75                  80  


Leu Val Val Asp Lys Pro Glu Gln Thr Val Lys Thr Phe Pro Leu Pro 
                85                  90                  95      


Ala Val Gly Leu Glu Arg Ala Ala Thr Thr Lys Ala Asp Lys Asp Ile 
            100                 105                 110         


Lys Asn Pro Ile Gln Pro Ser Phe Lys Met Leu Lys Asn Thr Lys Pro 
        115                 120                 125             


Met Thr Thr Phe Gln Glu Glu Thr Lys Ala Gln Phe Tyr Ala Ser Glu 
    130                 135                 140                 


Lys Thr Ser Pro Lys Arg Glu Leu Ala Lys Asp Leu Pro Lys Ser Gly 
145                 150                 155                 160 


Glu Ser Arg Cys Asn Pro Ser Glu Ala Gly Ala Ser Leu Leu Val Gly 
                165                 170                 175     


Ser Ile Glu Pro Ser Leu Ser Asn Gln Asp Arg Lys Tyr Ser Ser Thr 
            180                 185                 190         


Leu Pro Asn Asp Val Gln Thr Thr Ser Gly Asp Leu Lys Leu Asp Lys 
        195                 200                 205             


Ile Asp Pro Gln Arg Gln Glu Leu Leu Val Lys Leu Leu Asp Val Pro 
    210                 215                 220                 


Thr Gly Asp Cys His Ile Ser Pro Lys Asn Val Ser Asp Gly Val Lys 
225                 230                 235                 240 


Arg Val Arg Thr Leu Leu Ser Asn Glu Arg Asp Ser Lys Gly Arg Asp 
                245                 250                 255     


His Leu Ser Gly Val Pro Thr Asp Val Thr Val Thr Glu Thr Pro Glu 
            260                 265                 270         


Lys Asn Thr Glu Ser Leu Ile Leu Ser Leu Lys Met Ser Ser Leu Gly 
        275                 280                 285             


Lys Ile Gln Val Met Glu Lys Gln Glu Lys Gly Leu Thr Leu Gly Val 
    290                 295                 300                 


Glu Thr Cys Gly Ser Lys Gly Asn Ala Glu Lys Ser Met Ser Ala Thr 
305                 310                 315                 320 


Glu Lys Gln Glu Arg Thr Val Met Ser His Gly Cys Glu Asn Phe Asn 
                325                 330                 335     


Thr Arg Asp Ser Val Thr Gly Lys Glu Ser Gln Gly Glu Arg Pro His 
            340                 345                 350         


Leu Ser Leu Phe Ile Pro Arg Glu Thr Thr Tyr Gln Phe His Ser Val 
        355                 360                 365             


Ser Gln Ser Ser Ser Gln Ser Leu Ala Ser Leu Ala Thr Thr Phe Leu 
    370                 375                 380                 


Gln Glu Lys Lys Ala Glu Ala Gln Asn His Asn Cys Val Pro Asp Val 
385                 390                 395                 400 


Lys Ala Leu Met Glu Ser Pro Glu Gly Gln Leu Ser Leu Glu Pro Lys 
                405                 410                 415     


Ser Asp Ser Gln Phe Gln Ala Ser His Thr Gly Cys Gln Ser Pro Leu 
            420                 425                 430         


Cys Ser Ala Gln Arg His Thr Pro Gln Ser Pro Phe Thr Asn His Ala 
        435                 440                 445             


Ala Ala Ala Gly Arg Lys Thr Leu Arg Ser Cys Met Gly Leu Glu Trp 
    450                 455                 460                 


Phe Pro Glu Leu Tyr Pro Gly Tyr Leu Gly Leu Gly Val Leu Pro Gly 
465                 470                 475                 480 


Lys Pro Gln Cys Trp Asn Ala Met Thr Gln Lys Pro Gln Leu Ile Ser 
                485                 490                 495     


Pro Gln Gly Glu Arg Leu Ser Gln Val Ser Leu Leu Glu Arg Ser Ser 
            500                 505                 510         


Thr His Ile Arg Ser Leu Glu Pro Pro Ala Gly Leu Thr Thr Ser Asn 
        515                 520                 525             


Phe Ser Leu Met Arg Leu Leu Gly Ala Val Gln Lys Gly Trp Ile Arg 
    530                 535                 540                 


Cys Asn Thr Thr Ile Arg Lys Ser Gly Phe Gly Gly Ile Thr Met Leu 
545                 550                 555                 560 


Phe Thr Gly Tyr Phe Val Leu Cys Cys Ser Trp Ser Phe Arg Arg Leu 
                565                 570                 575     


Lys Lys Leu Cys Arg Pro Leu Pro Trp Lys Ser Thr Val Pro Pro Cys 
            580                 585                 590         


Ile Gly Val Ala Lys Thr Thr Gly Asp Cys Arg Ser Lys Thr Cys Leu 
        595                 600                 605             


Asp 
    


<210>  3564
<211>  3121
<212>  DNA
<213>  Homosapiens

<400>  3564
gccagaggga aacaaacgcc ggcgctgaca ggggccgcca gcccctccgc cgcgcggagc     60

ccacgaaggg gacagcgcag ccggcccaga gctcgggtct ccggggaccg agccttatga    120

tctcctcatt gcgtccccct ctgcccactg gacttggact tcagatctga ccccagacct    180

gccggctacc tcgggagggc ccacctcccc gcccatccag caagatgcca atcctcaagc    240

aactggtgtc cagctcggtg cactccaagc gccgttcccg agcggacctc acggccgaga    300

tgatcagcgc cccgctgggc gacttccgcc acaccatgca cgttggccgg gccggagacg    360

cctttgggga cacctccttc ctcaatagca aggctggcga gcccgacggc gagtccttgg    420

acgaacagcc ctcttcttca tcttccaaac gcagtctcct gtccaggaag ttccggggca    480

gcaagcggtc acagtcggtg accagggggg agcgggagca gcgtgacatg ctgggctccc    540

tgcgggactc ggccctgttt gtcaagaatg ccatgtccct gccccagctc aatgagaagg    600

aggccgcgga gaagggcacc agtaagctgc ccaagagcct gtcatccagc cccgtgaaga    660

aggccaatga cggggagggc ggcgatgagg aggcgggcac ggaggaggca gtgccccgtc    720

ggaatggggc cgcgggtcca cattcccctg accccctcct cgatgagcag gcctttgggg    780

atctgacaga tctgcctgtc gtgcccaagg ccacgtacgg gctgaagcat gcggagtcca    840

tcatgtcctt ccacatcgac ctggggccct ccatgctggg tgacgtcctc agcatcatgg    900

acaaggagga gtgggacccc gaggaggggg agggtggtta ccatggcgat gagggcgccg    960

ctggcaccat cacccaggct cccccgtacg ccgtggcggc ccctcccctg gcaaggcagg   1020

aaggcaaggc tggcccagac ttgccctccc tcccctccca tgctctggag gatgaggggt   1080

gggcagcagc ggcccccagc cccggctcag cccgcagcat gggcagccac accacacggg   1140

acagcagctc cctctccagc tgcacctcag gcatcctgga ggagcgcagc cctgccttcc   1200

gggggccgga cagggcccgg gctgctgtct caagacagcc agacaaggag ttctccttca   1260

tggatgagga ggaggaggat gaaatccgtg tgtgaggcgg acagtgggtg gccaccggga   1320

gctcttggct gcatcttctc cctgccccca ccccactatg acctttgacc ctacggcgca   1380

ggggcagcca ggacccttga ttcagaccat ggaccctgga ccttgtagat gagggacact   1440

ggcctggccc tcgggtcttc ggaggacgta gggggctggc atgggtgccg actggctgcc   1500

tgacttcatc atgctccctg cacttaggct gcgtgggaca agggctgtgt tgtcacagca   1560

ggaataggtt ttcctctgtt ggcctccctt tcctccaccc tggcctcaaa tggatgccag   1620

atgccaaccc cagttctggc cacgtacagc cagcgggtca gcccagaggc agcctcagct   1680

ccagggctaa ggactctcgg ctcccatttt ctctgctggc gtttctgctg tgcccagcag   1740

tggctgctgg ggaagcagct gcagcaggag ggagacggtc ttgcctctca gcccctccct   1800

gccccacccc agctcctgcc ctggaaatct ggagcccctt ggagctgagc tggacggggg   1860

gccagctgcg agcatgtgca ctaaacgcag ccctttccag gggaagagaa caggatggag   1920

aatggaagga aagcccccca ggcttcgtga attgcaagaa gggacccttc caggatgaca   1980

ctaggaacag ggctagggca ctcgctcagt ccctaggggc ttgtttgttc tttattattg   2040

tgtttaaatc cttatagagc aatatcagga tggtgttaat aggtctgcct cagaatgaga   2100

atcaatcctt ttagaaaacc tttatactaa gcctcctctt caaaattcac agtggcgatt   2160

agcggactgg agtctggtgg cgattagcgg actggagtct ggggacatcc gtggcaaaga   2220

caccagctca actttagtgc ttcccaactt tatttagaat gacatggggt gggtgtctgg   2280

tgtgtgtgtt ttccctacgc acctcccata gctattaaca actgaggaag gccagtgcag   2340

aatatttttg gagaacgatt ttttttttaa ataatatatc attcctatgg ggggaaagcc   2400

ttttttttct ttttggctga gttattccct ccctcccctc aataccctca gtactgacta   2460

cttccctttc ttttctcagg cctcccccca ccgacttttg aggccagggt tggccagatt   2520

tagcaaaacc aaaacagagt gctgagttaa acgcaaattt caggtaaaca aaagataatt   2580

ttctagcatt aatatgcccc acgcaatatt tggaacactt atgtgaaaaa tgatttgttt   2640

ttctgaaatt cacgtttctc tctgagtcct gtaactgtcc ccgaggggat tgagcagaag   2700

ctcgggtatg agccctgagg ttgactgccg gttatttttc tgtcctggga acagcctgac   2760

ccacctccct gtctccatgt agccagtgag gggaggggga gacacagaac caaccacagc   2820

caggggcgtc cccatggcga ctgtggcccg gcccctcctc tcttgcctga ctctcctctc   2880

ttgcctgact ctagacacta acttagttcc aggttcggtg ccctgttggt gctcctgttt   2940

ccaatagctt aggtcccatg gtgggggagg aacctcaggg gctatgcagc ccccgccagc   3000

tgccctcgaa tcccgtccag gccaattcca gattctaaac tgattttttt catgatattg   3060

tcaaaacagt gaggaaacat taaaaaaaaa gccctaaagc aaaaaaaaaa aaaaaaaaaa   3120

a                                                                   3121


<210>  3565
<211>  356
<212>  PRT
<213>  Homosapiens

<400>  3565

Met Pro Ile Leu Lys Gln Leu Val Ser Ser Ser Val His Ser Lys Arg 
1               5                   10                  15      


Arg Ser Arg Ala Asp Leu Thr Ala Glu Met Ile Ser Ala Pro Leu Gly 
            20                  25                  30          


Asp Phe Arg His Thr Met His Val Gly Arg Ala Gly Asp Ala Phe Gly 
        35                  40                  45              


Asp Thr Ser Phe Leu Asn Ser Lys Ala Gly Glu Pro Asp Gly Glu Ser 
    50                  55                  60                  


Leu Asp Glu Gln Pro Ser Ser Ser Ser Ser Lys Arg Ser Leu Leu Ser 
65                  70                  75                  80  


Arg Lys Phe Arg Gly Ser Lys Arg Ser Gln Ser Val Thr Arg Gly Glu 
                85                  90                  95      


Arg Glu Gln Arg Asp Met Leu Gly Ser Leu Arg Asp Ser Ala Leu Phe 
            100                 105                 110         


Val Lys Asn Ala Met Ser Leu Pro Gln Leu Asn Glu Lys Glu Ala Ala 
        115                 120                 125             


Glu Lys Gly Thr Ser Lys Leu Pro Lys Ser Leu Ser Ser Ser Pro Val 
    130                 135                 140                 


Lys Lys Ala Asn Asp Gly Glu Gly Gly Asp Glu Glu Ala Gly Thr Glu 
145                 150                 155                 160 


Glu Ala Val Pro Arg Arg Asn Gly Ala Ala Gly Pro His Ser Pro Asp 
                165                 170                 175     


Pro Leu Leu Asp Glu Gln Ala Phe Gly Asp Leu Thr Asp Leu Pro Val 
            180                 185                 190         


Val Pro Lys Ala Thr Tyr Gly Leu Lys His Ala Glu Ser Ile Met Ser 
        195                 200                 205             


Phe His Ile Asp Leu Gly Pro Ser Met Leu Gly Asp Val Leu Ser Ile 
    210                 215                 220                 


Met Asp Lys Glu Glu Trp Asp Pro Glu Glu Gly Glu Gly Gly Tyr His 
225                 230                 235                 240 


Gly Asp Glu Gly Ala Ala Gly Thr Ile Thr Gln Ala Pro Pro Tyr Ala 
                245                 250                 255     


Val Ala Ala Pro Pro Leu Ala Arg Gln Glu Gly Lys Ala Gly Pro Asp 
            260                 265                 270         


Leu Pro Ser Leu Pro Ser His Ala Leu Glu Asp Glu Gly Trp Ala Ala 
        275                 280                 285             


Ala Ala Pro Ser Pro Gly Ser Ala Arg Ser Met Gly Ser His Thr Thr 
    290                 295                 300                 


Arg Asp Ser Ser Ser Leu Ser Ser Cys Thr Ser Gly Ile Leu Glu Glu 
305                 310                 315                 320 


Arg Ser Pro Ala Phe Arg Gly Pro Asp Arg Ala Arg Ala Ala Val Ser 
                325                 330                 335     


Arg Gln Pro Asp Lys Glu Phe Ser Phe Met Asp Glu Glu Glu Glu Asp 
            340                 345                 350         


Glu Ile Arg Val 
        355     


<210>  3566
<211>  6628
<212>  DNA
<213>  Homosapiens

<400>  3566
tcaccatccc caaccccacc ggcagcgacg ccggctacta cgagtgcgag gctgtcctgc     60

gcagcagcag cgtcccctct gttgtccggg gcgcctacct ctcagtgctg gaaccgcctc    120

agtttgtcaa ggagccagaa agacacatca ctgcggagat ggagaaggtg gtggacatcc    180

cctgtcaggc caaaggtgtg ccgccgccct ccatcacctg gtacaaggac gcagccgtgg    240

tggaggtgga gaagttgacc cgcttccggc agcgcaacga cgggggcctg cagatcagcg    300

gcctggtgcc cgatgatacc ggcatgttcc agtgcttcgc ccgcaatgca gccggcgagg    360

tgcaaacttc cacctacctg gctgtcacca gcatcgcccc taacatcacc agaggccccc    420

tggacagcac ggtgatcgat ggcatgtcag tggtgctagc atgtgagacc tcgggggcgc    480

cccgaccagc tatcacttgg cagaaagggg agcgcatctt ggccagtggc tctgtgcagc    540

tgcctcgctt cacacccctg gagtcgggca gcctcctcat cagccccaca cacatctccg    600

atgcggggac ctacacctgc ctggccacca actctcgggg ggtcgatgag gcctcagcag    660

acctagtcgt ttgggctcgg acccgcatca ccaagccccc ccaggatcag agtgtcatca    720

agggcaccca ggcctccatg gtgtgcggag tgacccacga cccccgagta accatcaggt    780

acatctggga gaaggacggg gccaccctgg gcacggagag ccatcctcgt atccgcctgg    840

acagaaacgg ctccctgcac atctcacaga cgtggtcggg agacatcggc acgtacacct    900

gccgggtgat ctcagcagga ggcaacgact ctcgcagtgc ccacctgcga gtcaggcaac    960

tgccccacgc gcccgagcac ccagtggcca ctctcagcac cgtggaaagg cgagccatca   1020

acctgacgtg gaccaagccc tttgatggca acagccccct gatccgctac attctggaga   1080

tgtcggagaa caatgccccc tggactgtac tcctggccag tgtggacccc aaagctacct   1140

cagtgacagt caagggcctg gttcctgcac gctcctacca gttccgtctt tgtgccgtca   1200

acgacgtggg gaaaggacag ttcagcaaag acaccgagag ggtctccctc cccgaggagc   1260

cccccacggc ccctccacag aacgtcatcg ccagcggtcg aaccaaccag tccatcatga   1320

tccagtggca gccgcctcct gagagccacc agaatggaat tctcaagggt tacatcatca   1380

ggtactgcct ggccgggctg cccgtggggt accagtttaa gaacatcacg gatgctgatg   1440

tgaacaacct gctgctggag gatctcatca tttggaccaa ctacgagatc gaggtggctg   1500

cttacaacag cgctgggctg ggggtctaca gcagtaaagt caccgagtgg acgctgcagg   1560

gagttcccac agtccctccg ggcaatgtgc acgcggaagc caccaattcc acgaccatcc   1620

gcttcacctg gaacgccccc agcccccagt tcatcaacgg catcaaccag ggctacaagc   1680

tgatcgcctg ggagccggaa caggaagagg aggttaccat ggtgaccgcc cggcctaact   1740

ttcaagacag catccacgtg ggcttcgtgt ctggcctgaa gaagttcacc gagtacttca   1800

cctcagtgct gtgtttcacc acccccgggg acgggccacg cagcaccccg cagctggtgc   1860

gcacccatga ggatgtgcct gggcccgtgg gacacctgag cttcagtgag atcctggaca   1920

catcgctgaa ggtcagctgg caagagccgg gagagaaaaa tggcatcctc acagggtacc   1980

ggatctcctg ggaggagtac aatcgaacca acacccgtgt gacccactac ctgcccaacg   2040

tgaccctgga gtaccgtgtc acgggcctca ccgcgctcac cacctacacc atcgaggtgg   2100

ccgccatgac ctcaaagggc cagggccaag tgtccgcctc caccatctcc tctggggtgc   2160

ccccagaact cccagggccc cccaccaacc tgggcatttc caacatcggc ccccgctctg   2220

tgaccttgca gttcaggcca ggctacgatg ggaaaacctc catctcccgc tggctggtgg   2280

aagcccaggt aggcgtggtt ggggagggag aggagtggtt gctgatccac cagctctcca   2340

atgagcccga tgcccgctcc atggaggtgc ccgacctcaa ccccttcacc tgctacagct   2400

tccgcatgcg ccaggtgaac atcgtgggca ccagcccccc cagtcagcct tctagaaaga   2460

tccagaccct gcaggcaccc cctgacatgg ccccagccaa tgtgtctctg cgcacagcca   2520

gtgagaccag cctgtggctg cgctggatgc ctctcccgga gatggaatac aatgggaacc   2580

ctgagtccgt gggctataag atcaagtaca gccggtcaga cgggcatggc aagacgctga   2640

gccacgtggt gcaggaccgt gtggagcggg actacaccat cgaggacctg gaggagtgga   2700

cagagtaccg cgtccaggtc caggccttca acgccatcgg gagcgggccc tggagccaga   2760

cggtggtggg caggacccgg gagtcagttc cctcttccgg ccccaccaat gtgtctgcac   2820

tggccaccac ctccagcagc atgctggtgc gctggagcga ggtccccgag gctgatcgca   2880

acgggctcgt gctgggctat aaggtgatgt ataaggagaa ggactcggac acccagcccc   2940

gattctggct ggtggaaggc aactcgtctc gcagtgccca gctcaccggc ttgggcaaat   3000

acgtgctcta tgaagtccag gtgctggcct tcacacgcat cggggacggc agccccagcc   3060

accctcccat cctggagcgg acgctggatg atgtcccagg accacccatg ggcatcctgt   3120

tcccagaggt gcggaccacg tctgtgcggc tgatctggca gccccctgcc gcccccaatg   3180

gcatcattct tgcttaccag atcacacacc ggctcaacac caccacggcc aacaccgcca   3240

ctgtggaggt gctggcaccc agcgcccggc agtacacagc cacgggcctc aagccagagt   3300

ctgtctacct gttccgcatc acggcccaga cccgcaaggg ctggggagaa gctgccgagg   3360

ccttggtggt gaccaccgag aagagagacc gtccgcagcc ccccagcagg ccgatggtgc   3420

agcaggagga tgtgagagca cgcagcgtgc tgctgtcctg ggagccaggg agcgacgggc   3480

tctcccctgt gcgctactac accatccaga cccgcgagct gcccagcggc aggtgggcac   3540

tgcactcggc ctccgtgagc cacaatgcct ccagcttcat tgtggacagg ctgaagccct   3600

tcacgtccta caagttccga gtgaaggcga ccaatgacat tggcgacagc gagttcagcg   3660

aggagtcgga gtcactgacc accctgcagg ctgcccccga tgaagcaccc accatcctct   3720

ccgtgacgcc ccacaccacc acctccgtgc taatccgatg gcagccgcca gcagaggaca   3780

agatcaatgg catcctcctg ggcttccgga tccgataccg ggagctgctc tatgaaggac   3840

tgaggggctt cacgcttcga ggcatcaaca acccaggggc cacatgggct gagcttacct   3900

ccatgtactc catgcggaac ctgagccggc ccagcctcac gcagtacgag ctggacaacc   3960

tgaacaagca caggcggtac gagatacgga tgagcgtgta caacgctgtg ggtgaggggc   4020

cctccagccc cccgcaggag gtctttgttg gggaggcagt gcccacagca gcacctcgta   4080

acgtggtcgt ccacggcgcc acggccacac agctggacgt gacttgggag ccacctccgc   4140

tggacagcca gaatggagac atccaggggt acaagattta tttctgggaa gcccagcggg   4200

ggaacctcac agagcgagtg aagacgcttt tcctggctga gaacagcgtg aagctcaaga   4260

acttgactgg ctacacggcc tacatggtca gcgtggccgc cttcaacgcc gctggggatg   4320

ggcctcggag cacccccacc caaggccaga cccagcaagc agcccccagc gctcccagct   4380

cggtcaagtt cagtgagctg accacaacct cagtgaatgt gtcctgggaa gccccgcagt   4440

tccccaatgg catcctggag ggctacaggc tggtgtacga gccctgcagc cccgtggatg   4500

gagtcagcaa gatcgtgacc gtggacgtga aggggaacag ccccctgtgg ctgaaggtga   4560

aggacctggc ggagggggtg acctacaggt tccgcatcag agccaagacc ttcacctacg   4620

ggccggagat cgaagccaac gtcaccacgg gccccggaga aggtgcccca ggaccgcctg   4680

gcgtgcccat catcgtgcgg tacagctctg ccatcgccat tcactggtcc agcggagacc   4740

cgggcaaagg gcccatcacc cgctacgtca tcgaggccag accttcagac gagggactat   4800

gggacatcct catcaaagac atccccaagg aggtgagctc ctacacgttc agcatggaca   4860

tcctgaagcc gggcgtgagc tatgacttcc gggtcatcgc ggtcaacgac tatggtttcg   4920

gcacccccag cagcccctcc cagtctgtgc cagcccagaa agccaacccc ttctatgagg   4980

agtggtggtt cttggtggtc attgccctgg tcggcctcat cttcatcctg cttctggtct   5040

tcgtgctcat catccggggc cagagcaaga agtacgccaa gaagacagac tcggggaaca   5100

gtgccaagtc tggagcccta ggccacagcg agatgatgag cttggatgaa agcagcttcc   5160

ctgccctgga actcaacaac aggcggctct ccgtcaagaa ctctttctgc cgaaagaacg   5220

gcctgtacac caggtctccc cccaggccca gcccaggcag cctgcactac tcggatgagg   5280

atgtcaccaa atacaacgac ctcatccctg cagagagcag cagcctgacg gagaagccct   5340

cagaaatctc cgactctcag ggaagtgaca gcgagtacga ggtcgactca aaccaccaga   5400

aggcccactc ctttgtcaac cactacatca gtgaccccac atactacaac tcgtggcggc   5460

gacagcagaa gggcatctcg agggcacagg cctacagcta cacggagagc gactcgggtg   5520

agccagacca caccaccgtc accaacagca ccagcaccca gcagggcagc ctctttcggc   5580

ccaaggccag tcggactcca acgccccaga acccccctaa ccccccaagt cagcagagca   5640

ccctctaccg tccccccagc agcctggccc caggctcccg ggctcccata gcaggatttt   5700

catcatttgt ttgacatcag aagaggaaaa agcagaaaga gaaatggcac caaactcctc   5760

cttcacccct cctctcactg cctgccagaa aacaaaaaca ccaagaaacc aagtcaactt   5820

ttcacctcct gagtttattt ttccagagat tccagggcca gcaaagccgg cgttcagaag   5880

gagggagaaa accgtgagag gatgtgtgtg gccagcagct cttcagcttt gagatggtgg   5940

ggttcactgc tcccttggga attacacgga gctggggaag tggctgtgtc actgctatgg   6000

acacggagtg gggcgggcat ctggagagag agagggagcg gaggctaagg actggaggcc   6060

gccaggcagg cgtggccgag ggaagaaaaa gcttctggat gtccagccag ctgccccctt   6120

ccagcccctc caggacccct ggacccactg ccgctgctct ctgcaaaaag aatgggcatc   6180

ccggaggcca cgcctatctt ctctctctgc tcctccttcc ctccatgcac catcactgtg   6240

gctggcaggc atcggacagc ctcatccaga ccccctgccc tgtcttggca acctctactg   6300

cccatctccc ctgctcaact tctccaccaa gcatttggtt tatttagaaa aaggaagaaa   6360

aacaaaaaac aaaaaactaa agggtgagaa tttgcttagc gccttccttg ttcctgcata   6420

ttttttaaaa tattgaatcc aaggaagaga gcccaagggt aggggagaaa ccccccacaa   6480

ctgacccctg cctccctgtg ctggaattga ctttcctgag catggacaag gaaaggtgaa   6540

gtctggggag cagaggtgta aataaggcga ctggccttgg cactgtggga tgattaggtt   6600

taacgcattg tgggcaagat aagaatga                                      6628


<210>  3567
<211>  1851
<212>  PRT
<213>  Homosapiens

<400>  3567

Met Glu Lys Val Val Asp Ile Pro Cys Gln Ala Lys Gly Val Pro Pro 
1               5                   10                  15      


Pro Ser Ile Thr Trp Tyr Lys Asp Ala Ala Val Val Glu Val Glu Lys 
            20                  25                  30          


Leu Thr Arg Phe Arg Gln Arg Asn Asp Gly Gly Leu Gln Ile Ser Gly 
        35                  40                  45              


Leu Val Pro Asp Asp Thr Gly Met Phe Gln Cys Phe Ala Arg Asn Ala 
    50                  55                  60                  


Ala Gly Glu Val Gln Thr Ser Thr Tyr Leu Ala Val Thr Ser Ile Ala 
65                  70                  75                  80  


Pro Asn Ile Thr Arg Gly Pro Leu Asp Ser Thr Val Ile Asp Gly Met 
                85                  90                  95      


Ser Val Val Leu Ala Cys Glu Thr Ser Gly Ala Pro Arg Pro Ala Ile 
            100                 105                 110         


Thr Trp Gln Lys Gly Glu Arg Ile Leu Ala Ser Gly Ser Val Gln Leu 
        115                 120                 125             


Pro Arg Phe Thr Pro Leu Glu Ser Gly Ser Leu Leu Ile Ser Pro Thr 
    130                 135                 140                 


His Ile Ser Asp Ala Gly Thr Tyr Thr Cys Leu Ala Thr Asn Ser Arg 
145                 150                 155                 160 


Gly Val Asp Glu Ala Ser Ala Asp Leu Val Val Trp Ala Arg Thr Arg 
                165                 170                 175     


Ile Thr Lys Pro Pro Gln Asp Gln Ser Val Ile Lys Gly Thr Gln Ala 
            180                 185                 190         


Ser Met Val Cys Gly Val Thr His Asp Pro Arg Val Thr Ile Arg Tyr 
        195                 200                 205             


Ile Trp Glu Lys Asp Gly Ala Thr Leu Gly Thr Glu Ser His Pro Arg 
    210                 215                 220                 


Ile Arg Leu Asp Arg Asn Gly Ser Leu His Ile Ser Gln Thr Trp Ser 
225                 230                 235                 240 


Gly Asp Ile Gly Thr Tyr Thr Cys Arg Val Ile Ser Ala Gly Gly Asn 
                245                 250                 255     


Asp Ser Arg Ser Ala His Leu Arg Val Arg Gln Leu Pro His Ala Pro 
            260                 265                 270         


Glu His Pro Val Ala Thr Leu Ser Thr Val Glu Arg Arg Ala Ile Asn 
        275                 280                 285             


Leu Thr Trp Thr Lys Pro Phe Asp Gly Asn Ser Pro Leu Ile Arg Tyr 
    290                 295                 300                 


Ile Leu Glu Met Ser Glu Asn Asn Ala Pro Trp Thr Val Leu Leu Ala 
305                 310                 315                 320 


Ser Val Asp Pro Lys Ala Thr Ser Val Thr Val Lys Gly Leu Val Pro 
                325                 330                 335     


Ala Arg Ser Tyr Gln Phe Arg Leu Cys Ala Val Asn Asp Val Gly Lys 
            340                 345                 350         


Gly Gln Phe Ser Lys Asp Thr Glu Arg Val Ser Leu Pro Glu Glu Pro 
        355                 360                 365             


Pro Thr Ala Pro Pro Gln Asn Val Ile Ala Ser Gly Arg Thr Asn Gln 
    370                 375                 380                 


Ser Ile Met Ile Gln Trp Gln Pro Pro Pro Glu Ser His Gln Asn Gly 
385                 390                 395                 400 


Ile Leu Lys Gly Tyr Ile Ile Arg Tyr Cys Leu Ala Gly Leu Pro Val 
                405                 410                 415     


Gly Tyr Gln Phe Lys Asn Ile Thr Asp Ala Asp Val Asn Asn Leu Leu 
            420                 425                 430         


Leu Glu Asp Leu Ile Ile Trp Thr Asn Tyr Glu Ile Glu Val Ala Ala 
        435                 440                 445             


Tyr Asn Ser Ala Gly Leu Gly Val Tyr Ser Ser Lys Val Thr Glu Trp 
    450                 455                 460                 


Thr Leu Gln Gly Val Pro Thr Val Pro Pro Gly Asn Val His Ala Glu 
465                 470                 475                 480 


Ala Thr Asn Ser Thr Thr Ile Arg Phe Thr Trp Asn Ala Pro Ser Pro 
                485                 490                 495     


Gln Phe Ile Asn Gly Ile Asn Gln Gly Tyr Lys Leu Ile Ala Trp Glu 
            500                 505                 510         


Pro Glu Gln Glu Glu Glu Val Thr Met Val Thr Ala Arg Pro Asn Phe 
        515                 520                 525             


Gln Asp Ser Ile His Val Gly Phe Val Ser Gly Leu Lys Lys Phe Thr 
    530                 535                 540                 


Glu Tyr Phe Thr Ser Val Leu Cys Phe Thr Thr Pro Gly Asp Gly Pro 
545                 550                 555                 560 


Arg Ser Thr Pro Gln Leu Val Arg Thr His Glu Asp Val Pro Gly Pro 
                565                 570                 575     


Val Gly His Leu Ser Phe Ser Glu Ile Leu Asp Thr Ser Leu Lys Val 
            580                 585                 590         


Ser Trp Gln Glu Pro Gly Glu Lys Asn Gly Ile Leu Thr Gly Tyr Arg 
        595                 600                 605             


Ile Ser Trp Glu Glu Tyr Asn Arg Thr Asn Thr Arg Val Thr His Tyr 
    610                 615                 620                 


Leu Pro Asn Val Thr Leu Glu Tyr Arg Val Thr Gly Leu Thr Ala Leu 
625                 630                 635                 640 


Thr Thr Tyr Thr Ile Glu Val Ala Ala Met Thr Ser Lys Gly Gln Gly 
                645                 650                 655     


Gln Val Ser Ala Ser Thr Ile Ser Ser Gly Val Pro Pro Glu Leu Pro 
            660                 665                 670         


Gly Pro Pro Thr Asn Leu Gly Ile Ser Asn Ile Gly Pro Arg Ser Val 
        675                 680                 685             


Thr Leu Gln Phe Arg Pro Gly Tyr Asp Gly Lys Thr Ser Ile Ser Arg 
    690                 695                 700                 


Trp Leu Val Glu Ala Gln Val Gly Val Val Gly Glu Gly Glu Glu Trp 
705                 710                 715                 720 


Leu Leu Ile His Gln Leu Ser Asn Glu Pro Asp Ala Arg Ser Met Glu 
                725                 730                 735     


Val Pro Asp Leu Asn Pro Phe Thr Cys Tyr Ser Phe Arg Met Arg Gln 
            740                 745                 750         


Val Asn Ile Val Gly Thr Ser Pro Pro Ser Gln Pro Ser Arg Lys Ile 
        755                 760                 765             


Gln Thr Leu Gln Ala Pro Pro Asp Met Ala Pro Ala Asn Val Ser Leu 
    770                 775                 780                 


Arg Thr Ala Ser Glu Thr Ser Leu Trp Leu Arg Trp Met Pro Leu Pro 
785                 790                 795                 800 


Glu Met Glu Tyr Asn Gly Asn Pro Glu Ser Val Gly Tyr Lys Ile Lys 
                805                 810                 815     


Tyr Ser Arg Ser Asp Gly His Gly Lys Thr Leu Ser His Val Val Gln 
            820                 825                 830         


Asp Arg Val Glu Arg Asp Tyr Thr Ile Glu Asp Leu Glu Glu Trp Thr 
        835                 840                 845             


Glu Tyr Arg Val Gln Val Gln Ala Phe Asn Ala Ile Gly Ser Gly Pro 
    850                 855                 860                 


Trp Ser Gln Thr Val Val Gly Arg Thr Arg Glu Ser Val Pro Ser Ser 
865                 870                 875                 880 


Gly Pro Thr Asn Val Ser Ala Leu Ala Thr Thr Ser Ser Ser Met Leu 
                885                 890                 895     


Val Arg Trp Ser Glu Val Pro Glu Ala Asp Arg Asn Gly Leu Val Leu 
            900                 905                 910         


Gly Tyr Lys Val Met Tyr Lys Glu Lys Asp Ser Asp Thr Gln Pro Arg 
        915                 920                 925             


Phe Trp Leu Val Glu Gly Asn Ser Ser Arg Ser Ala Gln Leu Thr Gly 
    930                 935                 940                 


Leu Gly Lys Tyr Val Leu Tyr Glu Val Gln Val Leu Ala Phe Thr Arg 
945                 950                 955                 960 


Ile Gly Asp Gly Ser Pro Ser His Pro Pro Ile Leu Glu Arg Thr Leu 
                965                 970                 975     


Asp Asp Val Pro Gly Pro Pro Met Gly Ile Leu Phe Pro Glu Val Arg 
            980                 985                 990         


Thr Thr Ser Val Arg Leu Ile Trp  Gln Pro Pro Ala Ala  Pro Asn Gly 
        995                 1000                 1005             


Ile Ile  Leu Ala Tyr Gln Ile  Thr His Arg Leu Asn  Thr Thr Thr 
    1010                 1015                 1020             


Ala Asn  Thr Ala Thr Val Glu  Val Leu Ala Pro Ser  Ala Arg Gln 
    1025                 1030                 1035             


Tyr Thr  Ala Thr Gly Leu Lys  Pro Glu Ser Val Tyr  Leu Phe Arg 
    1040                 1045                 1050             


Ile Thr  Ala Gln Thr Arg Lys  Gly Trp Gly Glu Ala  Ala Glu Ala 
    1055                 1060                 1065             


Leu Val  Val Thr Thr Glu Lys  Arg Asp Arg Pro Gln  Pro Pro Ser 
    1070                 1075                 1080             


Arg Pro  Met Val Gln Gln Glu  Asp Val Arg Ala Arg  Ser Val Leu 
    1085                 1090                 1095             


Leu Ser  Trp Glu Pro Gly Ser  Asp Gly Leu Ser Pro  Val Arg Tyr 
    1100                 1105                 1110             


Tyr Thr  Ile Gln Thr Arg Glu  Leu Pro Ser Gly Arg  Trp Ala Leu 
    1115                 1120                 1125             


His Ser  Ala Ser Val Ser His  Asn Ala Ser Ser Phe  Ile Val Asp 
    1130                 1135                 1140             


Arg Leu  Lys Pro Phe Thr Ser  Tyr Lys Phe Arg Val  Lys Ala Thr 
    1145                 1150                 1155             


Asn Asp  Ile Gly Asp Ser Glu  Phe Ser Glu Glu Ser  Glu Ser Leu 
    1160                 1165                 1170             


Thr Thr  Leu Gln Ala Ala Pro  Asp Glu Ala Pro Thr  Ile Leu Ser 
    1175                 1180                 1185             


Val Thr  Pro His Thr Thr Thr  Ser Val Leu Ile Arg  Trp Gln Pro 
    1190                 1195                 1200             


Pro Ala  Glu Asp Lys Ile Asn  Gly Ile Leu Leu Gly  Phe Arg Ile 
    1205                 1210                 1215             


Arg Tyr  Arg Glu Leu Leu Tyr  Glu Gly Leu Arg Gly  Phe Thr Leu 
    1220                 1225                 1230             


Arg Gly  Ile Asn Asn Pro Gly  Ala Thr Trp Ala Glu  Leu Thr Ser 
    1235                 1240                 1245             


Met Tyr  Ser Met Arg Asn Leu  Ser Arg Pro Ser Leu  Thr Gln Tyr 
    1250                 1255                 1260             


Glu Leu  Asp Asn Leu Asn Lys  His Arg Arg Tyr Glu  Ile Arg Met 
    1265                 1270                 1275             


Ser Val  Tyr Asn Ala Val Gly  Glu Gly Pro Ser Ser  Pro Pro Gln 
    1280                 1285                 1290             


Glu Val  Phe Val Gly Glu Ala  Val Pro Thr Ala Ala  Pro Arg Asn 
    1295                 1300                 1305             


Val Val  Val His Gly Ala Thr  Ala Thr Gln Leu Asp  Val Thr Trp 
    1310                 1315                 1320             


Glu Pro  Pro Pro Leu Asp Ser  Gln Asn Gly Asp Ile  Gln Gly Tyr 
    1325                 1330                 1335             


Lys Ile  Tyr Phe Trp Glu Ala  Gln Arg Gly Asn Leu  Thr Glu Arg 
    1340                 1345                 1350             


Val Lys  Thr Leu Phe Leu Ala  Glu Asn Ser Val Lys  Leu Lys Asn 
    1355                 1360                 1365             


Leu Thr  Gly Tyr Thr Ala Tyr  Met Val Ser Val Ala  Ala Phe Asn 
    1370                 1375                 1380             


Ala Ala  Gly Asp Gly Pro Arg  Ser Thr Pro Thr Gln  Gly Gln Thr 
    1385                 1390                 1395             


Gln Gln  Ala Ala Pro Ser Ala  Pro Ser Ser Val Lys  Phe Ser Glu 
    1400                 1405                 1410             


Leu Thr  Thr Thr Ser Val Asn  Val Ser Trp Glu Ala  Pro Gln Phe 
    1415                 1420                 1425             


Pro Asn  Gly Ile Leu Glu Gly  Tyr Arg Leu Val Tyr  Glu Pro Cys 
    1430                 1435                 1440             


Ser Pro  Val Asp Gly Val Ser  Lys Ile Val Thr Val  Asp Val Lys 
    1445                 1450                 1455             


Gly Asn  Ser Pro Leu Trp Leu  Lys Val Lys Asp Leu  Ala Glu Gly 
    1460                 1465                 1470             


Val Thr  Tyr Arg Phe Arg Ile  Arg Ala Lys Thr Phe  Thr Tyr Gly 
    1475                 1480                 1485             


Pro Glu  Ile Glu Ala Asn Val  Thr Thr Gly Pro Gly  Glu Gly Ala 
    1490                 1495                 1500             


Pro Gly  Pro Pro Gly Val Pro  Ile Ile Val Arg Tyr  Ser Ser Ala 
    1505                 1510                 1515             


Ile Ala  Ile His Trp Ser Ser  Gly Asp Pro Gly Lys  Gly Pro Ile 
    1520                 1525                 1530             


Thr Arg  Tyr Val Ile Glu Ala  Arg Pro Ser Asp Glu  Gly Leu Trp 
    1535                 1540                 1545             


Asp Ile  Leu Ile Lys Asp Ile  Pro Lys Glu Val Ser  Ser Tyr Thr 
    1550                 1555                 1560             


Phe Ser  Met Asp Ile Leu Lys  Pro Gly Val Ser Tyr  Asp Phe Arg 
    1565                 1570                 1575             


Val Ile  Ala Val Asn Asp Tyr  Gly Phe Gly Thr Pro  Ser Ser Pro 
    1580                 1585                 1590             


Ser Gln  Ser Val Pro Ala Gln  Lys Ala Asn Pro Phe  Tyr Glu Glu 
    1595                 1600                 1605             


Trp Trp  Phe Leu Val Val Ile  Ala Leu Val Gly Leu  Ile Phe Ile 
    1610                 1615                 1620             


Leu Leu  Leu Val Phe Val Leu  Ile Ile Arg Gly Gln  Ser Lys Lys 
    1625                 1630                 1635             


Tyr Ala  Lys Lys Thr Asp Ser  Gly Asn Ser Ala Lys  Ser Gly Ala 
    1640                 1645                 1650             


Leu Gly  His Ser Glu Met Met  Ser Leu Asp Glu Ser  Ser Phe Pro 
    1655                 1660                 1665             


Ala Leu  Glu Leu Asn Asn Arg  Arg Leu Ser Val Lys  Asn Ser Phe 
    1670                 1675                 1680             


Cys Arg  Lys Asn Gly Leu Tyr  Thr Arg Ser Pro Pro  Arg Pro Ser 
    1685                 1690                 1695             


Pro Gly  Ser Leu His Tyr Ser  Asp Glu Asp Val Thr  Lys Tyr Asn 
    1700                 1705                 1710             


Asp Leu  Ile Pro Ala Glu Ser  Ser Ser Leu Thr Glu  Lys Pro Ser 
    1715                 1720                 1725             


Glu Ile  Ser Asp Ser Gln Gly  Ser Asp Ser Glu Tyr  Glu Val Asp 
    1730                 1735                 1740             


Ser Asn  His Gln Lys Ala His  Ser Phe Val Asn His  Tyr Ile Ser 
    1745                 1750                 1755             


Asp Pro  Thr Tyr Tyr Asn Ser  Trp Arg Arg Gln Gln  Lys Gly Ile 
    1760                 1765                 1770             


Ser Arg  Ala Gln Ala Tyr Ser  Tyr Thr Glu Ser Asp  Ser Gly Glu 
    1775                 1780                 1785             


Pro Asp  His Thr Thr Val Thr  Asn Ser Thr Ser Thr  Gln Gln Gly 
    1790                 1795                 1800             


Ser Leu  Phe Arg Pro Lys Ala  Ser Arg Thr Pro Thr  Pro Gln Asn 
    1805                 1810                 1815             


Pro Pro  Asn Pro Pro Ser Gln  Gln Ser Thr Leu Tyr  Arg Pro Pro 
    1820                 1825                 1830             


Ser Ser  Leu Ala Pro Gly Ser  Arg Ala Pro Ile Ala  Gly Phe Ser 
    1835                 1840                 1845             


Ser Phe  Val 
    1850     


<210>  3568
<211>  2318
<212>  DNA
<213>  Homosapiens

<400>  3568
tctagatgtg cagaaggtgc aagccagagc tcgggcagaa cttccagagt gcatctggga     60

tctgcatttg ccactggttg cagatcaggc ggacgaggag ccgggaaggc agagccatgt    120

ggctgccccc tgctctgctc cttctcagcc tctcaggctg tttctccatc caaggcccag    180

agtctgtgag agccccagag caggggtccc tgacggttca atgccactat aagcaaggat    240

gggagaccta cattaagtgg tggtgccgag gggtgcgctg ggatacatgc aagatcctca    300

ttgaaaccag agggtcggag caaggagaga agagtgaccg tgtgtccatc aaggacaatc    360

agaaagaccg cacgttcact gtgaccatgg aggggctcag gcgagatgac gcagatgttt    420

actggtgtgg gattgaaaga agaggacctg accttgggac tcaagtgaaa gtgatcgttg    480

acccagaggg agcggcttcc acaacagcaa gctcacctac caacagcaat atggcagtgt    540

tcatcggctc ccacaagagg aaccactaca tgctcctggt atttgtgaag gtgcccatct    600

tgctcatctt ggtcactgcc atcctctggt tgaaggggtc tcagagggtc cctgaggagc    660

caggggaaca gcctatctac atgaacttct ccgaacctct gactaaagac atggccactt    720

agagagatgg atctgcagag ccttcctgcc ctggccacgt ttccagaaga gactcgggct    780

gtggaaggaa catctacgag tcctcgggat gcagtgactg agataggggc cctgggcctc    840

cgccctggcc ttggagctgg tgggcacctc cctgttctgc acagctcagg gacttagcca    900

ggtcctctcc tgagccacca tcacctcctg gggtgccagc acctgttctc ttggtcagga    960

gctgtagaga tggagctcaa gcactggacg actctgtccc cactgctgga ataactcggg   1020

cacagagcat gggaccaaag tacagaaaga ggttggggga gaccccccca gccctagact   1080

tccatcattc cggagaccaa ctcaacaccg tctttgcctg agaacctgat atatccgtgt   1140

ttttaaattt ttttttttct agcaaagttg ggttttaatg acttatgttc ataggaaacc   1200

tctctgatcc cacacacaag gagggtgatt ctgggatgag ttcctggttc tagggcatga   1260

ggggctggat ggaccctgtc cccagggagg acatggctct gagtccacag ggctgaggag   1320

gcaatgggaa cctccctggc ccggcccggt gcttgtcctc cccctcccac ctcttcctcc   1380

tcctagctcc ccaagctccc tgcctattcc cccacctccg aggggctgca gcttgggagc   1440

ctcctcagca tgacagcttg ggtctcctcc ccaaaagagc ctgtcaggcc tcaagaacca   1500

cctccaggtg gggagggcag taacgaaaac catcgcagga aatggcaccc tcccttttcg   1560

gtgatgttga aatcatgtta ctaatgaaaa ctgtcctagg gaagtggttc tgtctcctca   1620

caggcttcac ccacggcgat gaggcccttg aatgtggtca ctttgtgctg tatggttgag   1680

ggaccctcac accaaaggga ccttcccatg tgagatgtgc tcccgccccc acctgcccac   1740

aagcaaacac accacacatg ttcggcatgt tgccctttga acacccatga ggacgcctcc   1800

aacctgctct tggttctaat agggagtact gactgtcagc agtggataaa ggagagggga   1860

ccctctggtc cctagcatgg cacccagagc ctcccctctt cttgtccttc agccaaagag   1920

aaactttctc tgactttgaa ctgaatttag gtctctggcc aatgatgggc ctgaaaattc   1980

cataatggcc agagaggaga gttcgagccc ggctaagatc ccctgagtca ttctgtgagg   2040

gaccaagacc cacagtccac cagccccagg gccctacctc ctggaatgct ttcctggatc   2100

cagcttcccg aagatccgac cagacccagg gaggacggca ccgctccgcg ggagggaaag   2160

ccaaagcatg gtgcttcacc agctggactc aggggcgagg ggacatgggc gcttgtcaac   2220

gtgatgtcat tcttttccca ccgtttcttc ctgttgatat tcaatgaatc cgtcaatctc   2280

tctggaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                           2318


<210>  3569
<211>  238
<212>  PRT
<213>  Homosapiens

<400>  3569

Met Cys Arg Arg Cys Lys Pro Glu Leu Gly Gln Asn Phe Gln Ser Ala 
1               5                   10                  15      


Ser Gly Ile Cys Ile Cys His Trp Leu Gln Ile Arg Arg Thr Arg Ser 
            20                  25                  30          


Arg Glu Gly Arg Ala Met Trp Leu Pro Pro Ala Leu Leu Leu Leu Ser 
        35                  40                  45              


Leu Ser Gly Cys Phe Ser Ile Gln Gly Pro Glu Ser Val Arg Ala Pro 
    50                  55                  60                  


Glu Gln Gly Ser Leu Thr Val Gln Cys His Tyr Lys Gln Gly Trp Glu 
65                  70                  75                  80  


Thr Tyr Ile Lys Trp Trp Cys Arg Gly Val Arg Trp Asp Thr Cys Lys 
                85                  90                  95      


Ile Leu Ile Glu Thr Arg Gly Ser Glu Gln Gly Glu Lys Ser Asp Arg 
            100                 105                 110         


Val Ser Ile Lys Asp Asn Gln Lys Asp Arg Thr Phe Thr Val Thr Met 
        115                 120                 125             


Glu Gly Leu Arg Arg Asp Asp Ala Asp Val Tyr Trp Cys Gly Ile Glu 
    130                 135                 140                 


Arg Arg Gly Pro Asp Leu Gly Thr Gln Val Lys Val Ile Val Asp Pro 
145                 150                 155                 160 


Glu Gly Ala Ala Ser Thr Thr Ala Ser Ser Pro Thr Asn Ser Asn Met 
                165                 170                 175     


Ala Val Phe Ile Gly Ser His Lys Arg Asn His Tyr Met Leu Leu Val 
            180                 185                 190         


Phe Val Lys Val Pro Ile Leu Leu Ile Leu Val Thr Ala Ile Leu Trp 
        195                 200                 205             


Leu Lys Gly Ser Gln Arg Val Pro Glu Glu Pro Gly Glu Gln Pro Ile 
    210                 215                 220                 


Tyr Met Asn Phe Ser Glu Pro Leu Thr Lys Asp Met Ala Thr 
225                 230                 235             


<210>  3570
<211>  1550
<212>  DNA
<213>  Homosapiens

<400>  3570
gaaatggccc agcttggctc tgccttctgc agtgtgagta acacactgaa gccagaagct     60

gtgggctgtg gggaagtggc tgcatcgcca cccaagggac cctggacttt gccagacgtc    120

agggttgaga ggagccacta gcaccatccc agagctgtca gcaccggcct cagcccaggc    180

ggctctctcc ctgagcttcc tgtaccctga ccctctccag cctcagacct gagacagggc    240

tggacaagga agcagagagc agaagaaaag cagaagcgaa gctcagatct gctgggagga    300

gactacattt tgtcccctcc tggggtcttg cacagtggca ggtgacattc gtgttacagg    360

aatgactgcc agggcctggg cctcgtggcg gtcttcagct ctgctcctcc tgcttgtccc    420

aggctatttt cctctgagcc accccatgac cgtggcgggc cccgtggggg gatccctgag    480

tgtgcagtgt cgctatgaga aggaacacag gaccctcaac aaattctggt gcagaccacc    540

acagattctc cgatgtgaca agattgtgga gaccaaaggg tcagcaggga aaaggaatgg    600

ccgagtgtcc atcagggaca gtcctgcaaa cctcagcttc acagtgaccc tggagaatct    660

cacagaggag gacgcaggca cctactggtg tggggtggat acaccgtggc tccgagactt    720

tcatgatccc attgtcgagg ttgaggtgtc cgtgttcccg gccgggacga ccacagcctc    780

cagcccccag agctccatgg gcacctcagg tcctcccacg aagctgcccg tgcacacctg    840

gcccagcgtg accagaaagg acagccccga acccagccca caccctggct ccctgttcag    900

caatgtccgc ttcctgctcc tggtcctctt ggagctgccc ctgctcctga gcatgctggg    960

tgccgtcctc tgggtgaaca gacctcagag aagctctaga agcaggcaga attggcccaa   1020

gggtgagaac cagtagcatc tgctgtccat caaggccctg tgctgcaaca gagcccctct   1080

gggggactgg aatgacctcc tgaccactcc ctcccgggct gctctctcca catctcctgg   1140

aatcctttgt gagcctcctt cagccttttc cctgtgcccg atcctcatgt gtcacatgtg   1200

aacctgacgg acatggacgc cctgagctgt gagtccacgt ctcatgtgca cgccccggcc   1260

agctaagcct cgggccgtca gcaatacctc tgagtgcccg gatgccctcc ctgcaccctt   1320

ccatttctcc aggagcctgg cactgcttcc tccaccgttt tcacagggag aagcaggtct   1380

aggactcccc tgcacctttg ccaccataat ggcccacact ccctgggtcc aggagtgtag   1440

aatatgcggc tgcttccatt tgctgagtgt gtcgattcaa tgatgctttc aaactttaat   1500

aaatgacaat gtgtaggcca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa              1550


<210>  3571
<211>  224
<212>  PRT
<213>  Homosapiens

<400>  3571

Met Thr Ala Arg Ala Trp Ala Ser Trp Arg Ser Ser Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Val Pro Gly Tyr Phe Pro Leu Ser His Pro Met Thr Val Ala 
            20                  25                  30          


Gly Pro Val Gly Gly Ser Leu Ser Val Gln Cys Arg Tyr Glu Lys Glu 
        35                  40                  45              


His Arg Thr Leu Asn Lys Phe Trp Cys Arg Pro Pro Gln Ile Leu Arg 
    50                  55                  60                  


Cys Asp Lys Ile Val Glu Thr Lys Gly Ser Ala Gly Lys Arg Asn Gly 
65                  70                  75                  80  


Arg Val Ser Ile Arg Asp Ser Pro Ala Asn Leu Ser Phe Thr Val Thr 
                85                  90                  95      


Leu Glu Asn Leu Thr Glu Glu Asp Ala Gly Thr Tyr Trp Cys Gly Val 
            100                 105                 110         


Asp Thr Pro Trp Leu Arg Asp Phe His Asp Pro Ile Val Glu Val Glu 
        115                 120                 125             


Val Ser Val Phe Pro Ala Gly Thr Thr Thr Ala Ser Ser Pro Gln Ser 
    130                 135                 140                 


Ser Met Gly Thr Ser Gly Pro Pro Thr Lys Leu Pro Val His Thr Trp 
145                 150                 155                 160 


Pro Ser Val Thr Arg Lys Asp Ser Pro Glu Pro Ser Pro His Pro Gly 
                165                 170                 175     


Ser Leu Phe Ser Asn Val Arg Phe Leu Leu Leu Val Leu Leu Glu Leu 
            180                 185                 190         


Pro Leu Leu Leu Ser Met Leu Gly Ala Val Leu Trp Val Asn Arg Pro 
        195                 200                 205             


Gln Arg Ser Ser Arg Ser Arg Gln Asn Trp Pro Lys Gly Glu Asn Gln 
    210                 215                 220                 


<210>  3572
<211>  2525
<212>  DNA
<213>  Homosapiens

<400>  3572
agtgccctaa agaggtactg ggagcggcag cagatacaag atcagtgccc taaagaggta     60

ctgggatatc agggtcacca tggtgggagc ggaagacaat ttcaccataa acaggcagag    120

ctccacaacc caaggaattc ctggaacaga aattggactc catgcccaaa tctgctttct    180

atggcatctg aagggaacta agaaactaca cacgacctcc tggggaaaga tgggtatagg    240

ggcttcattt gttcactctg aaaaaagttc tacatcagaa tggaaagaca acaattaagc    300

atctaacaca gaacctgtca gataacaaaa acttgattgc tatttaatga atatgggcat    360

ggatggatga attggcgctg tcattttccc tgacatgtct ccttcctgag aacagagcgt    420

ctctgtctcc aagccagccg ctgtcattcc agtgccttaa agctccagcc acactcacct    480

gggaggatga gaagcagcag agatggggac agccacatgg tcctgtctcc tctcctctcc    540

ttggtgatca caggtgtctg gtgcccttca gggacttgaa tccaagctcg gaagtcaaca    600

ccgcaaacct actcgaatct ccttcaagtc tcttgctcac ttcctgttac atctgtagct    660

acttctcttt ttacatatta ggagaaaaga ggtgtcattc tttgaaaaga ctaaggtaca    720

gtgtatgttg caaggtgtgc ccaaactttt gtgcatgtgg aaaagaaaat gtgtccggga    780

ctggtcaggt ttgcacggga gtgcacgtag gagccaagga gcaggaggag ccaggaggaa    840

cccaagcatt gaggagctgc gggatctact gcctggagga gaggacggac aaggccagcc    900

atgaggagtg cagggagagg agcactttgg gaagaccaca gtgcacagga ctcacaccca    960

gccttgctgg agaaagccca tgccccaggc ttcttccagg cagccccact gtaagacatc   1020

tcattgcctc ttcctgccct gggctgtctg acccactgcc ccttccccca ggaacacttc   1080

cactgggatc atgagtcact ctgaagccac tctgaaatca ctctgaagcc aaagctgggc   1140

tcagtgggga aggtcaggaa tggagaaatt gccttttctc gttagcctcc tcttgccctg   1200

atttcatcct ccctatccct gcacactttc ccctggctgc tgttgtaatc tacttgttct   1260

gctgacgccc gaactgactt ctttcccggt ctctccccac tttctttaga tggtcccttc   1320

cctctttctc tccctttccc tcctgaatcg attcattttt tctctcctgt tttatatttt   1380

ccatatctgt gggctttgtt ctacatttgg ggagcttttt atattgttta tttcatgctt   1440

gtactttccc ttccaatcct tggatcaaat attgatttta gagactgtat ttttatttcg   1500

aaaagttttt ttggttcttt gattactgat gttttcaaac tctcttctgt tccttgaact   1560

atatccctcc actcagtggt cacatctttg ttttgttgtc tgcttcttct atattatgag   1620

ccttcctcaa gtgtctgctg attcttggtt atccaatcat agttgagaac aagataaagt   1680

gtagctaact gagacctcag agtatgtagg agtaaatagt atataaaata gctctggtgg   1740

ctcatgcctg taatccagca ctttgggagg ccaaggcgga cagaccacct gaggtcagga   1800

gttcgaaacc agcctggcca acatggagaa accccatctc tactaaaaat acaaaaatta   1860

gccaggtggt ggcacacgcc tgtaatccca gctactcagg aggctgaggc aggagaatcg   1920

cctgaacctg ggaggtggag attgcagtga gcccagattg caccactgct ctctagcctg   1980

ggcaaaaaaa ctagttccaa aaaagacact tgtacacgca tgtttatagc agcacaattt   2040

gcgattgaaa acatagggaa ccagcctaaa tgcccatcaa gcaatgagtg gataaagaca   2100

atgcggtgta catatacacc atggaatact attcagccac aaaaaggaac aaaataatgg   2160

cattcacagc aacctggatg gagttggaga tcattattct aagtgaaata actcaggaat   2220

ggagaaccaa atattgtaca tcctcactta taagtgggag ctgcgctatg aagatacaaa   2280

ggcacaagaa tgatacaatg gattttgggg acttagggga aaggatgcag gggatgaggg   2340

ataaaaaacc atacattggg tacagtgtac actgctccag tgaagggtgc accaaaatct   2400

cagaagtcac tgctaaagac cttatccttg taaccaaaag ccatctgctc cccaaaaact   2460

attgaaataa aataaaatat aaaaagaaag agaaagaaaa gaaaatagtt ccaatttatc   2520

atgcc                                                               2525


<210>  3573
<211>  243
<212>  PRT
<213>  Homosapiens

<400>  3573

Met Asp Glu Leu Ala Leu Ser Phe Ser Leu Thr Cys Leu Leu Pro Glu 
1               5                   10                  15      


Asn Arg Ala Ser Leu Ser Pro Ser Gln Pro Leu Ser Phe Gln Cys Leu 
            20                  25                  30          


Lys Ala Pro Ala Thr Leu Thr Trp Glu Asp Glu Lys Gln Gln Arg Trp 
        35                  40                  45              


Gly Gln Pro His Gly Pro Val Ser Ser Pro Leu Leu Gly Asp His Arg 
    50                  55                  60                  


Cys Leu Val Pro Phe Arg Asp Leu Asn Pro Ser Ser Glu Val Asn Thr 
65                  70                  75                  80  


Ala Asn Leu Leu Glu Ser Pro Ser Ser Leu Leu Leu Thr Ser Cys Tyr 
                85                  90                  95      


Ile Cys Ser Tyr Phe Ser Phe Tyr Ile Leu Gly Glu Lys Arg Cys His 
            100                 105                 110         


Ser Leu Lys Arg Leu Arg Tyr Ser Val Cys Cys Lys Val Cys Pro Asn 
        115                 120                 125             


Phe Cys Ala Cys Gly Lys Glu Asn Val Ser Gly Thr Gly Gln Val Cys 
    130                 135                 140                 


Thr Gly Val His Val Gly Ala Lys Glu Gln Glu Glu Pro Gly Gly Thr 
145                 150                 155                 160 


Gln Ala Leu Arg Ser Cys Gly Ile Tyr Cys Leu Glu Glu Arg Thr Asp 
                165                 170                 175     


Lys Ala Ser His Glu Glu Cys Arg Glu Arg Ser Thr Leu Gly Arg Pro 
            180                 185                 190         


Gln Cys Thr Gly Leu Thr Pro Ser Leu Ala Gly Glu Ser Pro Cys Pro 
        195                 200                 205             


Arg Leu Leu Pro Gly Ser Pro Thr Val Arg His Leu Ile Ala Ser Ser 
    210                 215                 220                 


Cys Pro Gly Leu Ser Asp Pro Leu Pro Leu Pro Pro Gly Thr Leu Pro 
225                 230                 235                 240 


Leu Gly Ser 
            


<210>  3574
<211>  739
<212>  DNA
<213>  Homosapiens

<400>  3574
gacctagatt tgctgaggac ggaagccaag gagacaggaa catgtggctg ctcccagctc     60

tactccttct ctgcctctca ggctgtttgt ctctgacggg ccccggctct gtgactggca    120

ctgcggggga ctctctgaca gtgtggtgtc agtatgagag catgtacaag ggatataaca    180

agtactggtg ccgaggacag tacgacacgt catgtgagag cattgtggag accaagggag    240

aagagaaggt ggagaggaat ggccgcgtgt ccatcagaga ccacccggag gctctcgcct    300

tcactgtgac catgcagaac ctcaatgaag atgatgctgg atcttactgg tgcaaaattc    360

agacagtgtg ggtcctggat tcatggtcac gcgatccctc ggacctggtt agggtgtatg    420

tttccccagc aattacaacc ccaaggagga ccacacatcc agccacacct cccatcttcc    480

tggtggtgaa ccctgggcga aacctcagca ccggggaggt gttgacccaa aattcagggt    540

tccggctcag cagccctcac ttcctgctcg tggtccttct gaagctgccc ctgctcctga    600

gcatgctggg tgctgtcttc tgggtgaaca ggcctcagtg ggctcctcct ggaagataga    660

gccaggctga cccgaagccc tgcagagccc catccccagg agtgccccgt gcagggagtc    720

aacctttcag actggatgc                                                 739


<210>  3575
<211>  205
<212>  PRT
<213>  Homosapiens

<400>  3575

Met Trp Leu Leu Pro Ala Leu Leu Leu Leu Cys Leu Ser Gly Cys Leu 
1               5                   10                  15      


Ser Leu Thr Gly Pro Gly Ser Val Thr Gly Thr Ala Gly Asp Ser Leu 
            20                  25                  30          


Thr Val Trp Cys Gln Tyr Glu Ser Met Tyr Lys Gly Tyr Asn Lys Tyr 
        35                  40                  45              


Trp Cys Arg Gly Gln Tyr Asp Thr Ser Cys Glu Ser Ile Val Glu Thr 
    50                  55                  60                  


Lys Gly Glu Glu Lys Val Glu Arg Asn Gly Arg Val Ser Ile Arg Asp 
65                  70                  75                  80  


His Pro Glu Ala Leu Ala Phe Thr Val Thr Met Gln Asn Leu Asn Glu 
                85                  90                  95      


Asp Asp Ala Gly Ser Tyr Trp Cys Lys Ile Gln Thr Val Trp Val Leu 
            100                 105                 110         


Asp Ser Trp Ser Arg Asp Pro Ser Asp Leu Val Arg Val Tyr Val Ser 
        115                 120                 125             


Pro Ala Ile Thr Thr Pro Arg Arg Thr Thr His Pro Ala Thr Pro Pro 
    130                 135                 140                 


Ile Phe Leu Val Val Asn Pro Gly Arg Asn Leu Ser Thr Gly Glu Val 
145                 150                 155                 160 


Leu Thr Gln Asn Ser Gly Phe Arg Leu Ser Ser Pro His Phe Leu Leu 
                165                 170                 175     


Val Val Leu Leu Lys Leu Pro Leu Leu Leu Ser Met Leu Gly Ala Val 
            180                 185                 190         


Phe Trp Val Asn Arg Pro Gln Trp Ala Pro Pro Gly Arg 
        195                 200                 205 


<210>  3576
<211>  1749
<212>  DNA
<213>  Homosapiens

<400>  3576
tgcgctctcc ttcgcctgcg ggccggcact gctcacctct cgtccaggga catgacgggc     60

acgccaggcg ccgttgccac ccgggatggc gaggcccccg agcgctcccc gccctgcagt    120

ccgagctacg acctcacggg caaggtgatg cttctgggag acacaggcgt cggcaaaaca    180

tgtttcctga tccaattcaa agacggggcc ttcctgtccg gaaccttcat agccaccgtc    240

ggcatagact tcaggaacaa ggtggtgact gtggatggcg tgagagtgaa gctgcagatc    300

tgggacaccg ctgggcagga acggttccga agcgtcaccc atgcttatta cagagatgct    360

caggccttgc ttctgctgta tgacatcacc aacaaatctt ctttcgacaa catcagggcc    420

tggctcactg agattcatga gtatgcccag agggacgtgg tgatcatgct gctaggcaac    480

aaggcggata tgagcagcga aagagtgatc cgttccgaag acggagagac cttggccagg    540

gagtacggtg ttcccttcct ggagaccagc gccaagactg gcatgaatgt ggagttagcc    600

tttctggcca tcgccaagga actgaaatac cgggccgggc atcaggcgga tgagcccagc    660

ttccagatcc gagactatgt agagtcccag aagaagcgct ccagctgctg ctccttcatg    720

tgaatcccag ggggcagaga ggaggctctg gaggcacaca ggatgcagcc ttccccctcc    780

caggcctggc ttattccaag aggctggtct tgaattcctg agctcaagca acctgccggc    840

ctcggcctcc caaagtactg ggattacacg cagaaggcac catgcccagg ctagatgtgt    900

cttatcccaa tcctttggca ggcatgcagc tccacaggcg atttcttcaa gcagctgaag    960

tgtttagccc tcctgggtta agagccagat aaggagaaat ccctttccta ggtttggaat   1020

gtgttgtgaa aaaaaagaga aatccctggc tcctggagct ggtgggagac aagattaagc   1080

aaacctcccc tgacatgtat ccctttgacc ccaagctctg cctcctccct gaccacccat   1140

gccctttcct ttaacttctc aaacagatac cagggcctaa actgctttac ctcccctcct   1200

actgagtcag gttaggtggt gggaggtcac ccatttccga gttaaaccaa tgcaatatga   1260

gtaaaacaaa gtcatgtggg tatgtctggg gtagagagag gggtagcaag ttcatgtgtc   1320

ctccttggtc acatatctcc caaagctccg atccctgcca tgggaagtgg acaggaaaca   1380

tgaggtcatg acctgcaggc atctttactg cagctctgcc ggcctggagg gggagagggg   1440

gaggaagaag tatgcgctgc acatttctga ggctactgca tttgctttca aggcagaaat   1500

cttgctctga gcagtcagcg gctccagttt gggcccgata aggaagttct ccgtggcctc   1560

cctcaggcag agcagggagg aggctgacat tgccagtctc ttctggggcc caaggcaggt   1620

tgcaggagat ccaatcccat agacagctct gggcctcttg catttgagtt tttcagaatt   1680

aaactgcagt attttggaaa gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1740

aaaaaaaaa                                                           1749


<210>  3577
<211>  223
<212>  PRT
<213>  Homosapiens

<400>  3577

Met Thr Gly Thr Pro Gly Ala Val Ala Thr Arg Asp Gly Glu Ala Pro 
1               5                   10                  15      


Glu Arg Ser Pro Pro Cys Ser Pro Ser Tyr Asp Leu Thr Gly Lys Val 
            20                  25                  30          


Met Leu Leu Gly Asp Thr Gly Val Gly Lys Thr Cys Phe Leu Ile Gln 
        35                  40                  45              


Phe Lys Asp Gly Ala Phe Leu Ser Gly Thr Phe Ile Ala Thr Val Gly 
    50                  55                  60                  


Ile Asp Phe Arg Asn Lys Val Val Thr Val Asp Gly Val Arg Val Lys 
65                  70                  75                  80  


Leu Gln Ile Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Val Thr 
                85                  90                  95      


His Ala Tyr Tyr Arg Asp Ala Gln Ala Leu Leu Leu Leu Tyr Asp Ile 
            100                 105                 110         


Thr Asn Lys Ser Ser Phe Asp Asn Ile Arg Ala Trp Leu Thr Glu Ile 
        115                 120                 125             


His Glu Tyr Ala Gln Arg Asp Val Val Ile Met Leu Leu Gly Asn Lys 
    130                 135                 140                 


Ala Asp Met Ser Ser Glu Arg Val Ile Arg Ser Glu Asp Gly Glu Thr 
145                 150                 155                 160 


Leu Ala Arg Glu Tyr Gly Val Pro Phe Leu Glu Thr Ser Ala Lys Thr 
                165                 170                 175     


Gly Met Asn Val Glu Leu Ala Phe Leu Ala Ile Ala Lys Glu Leu Lys 
            180                 185                 190         


Tyr Arg Ala Gly His Gln Ala Asp Glu Pro Ser Phe Gln Ile Arg Asp 
        195                 200                 205             


Tyr Val Glu Ser Gln Lys Lys Arg Ser Ser Cys Cys Ser Phe Met 
    210                 215                 220             


<210>  3578
<211>  1972
<212>  DNA
<213>  Homosapiens

<400>  3578
tgcgctctcc ttcgcctgcg ggccggcact gctcacctct cgtccaggga catgacgggc     60

acgccaggcg ccgttgccac ccgggatggc gaggcccccg agcgctcccc gccctgcagt    120

ccgagctacg acctcacggg caaggtgatg cttctgggag acacaggcgt cggcaaaaca    180

tgtttcctga tccaattcaa agacggggcc ttcctgtccg gaaccttcat agccaccgtc    240

ggcatagact tcaggaacaa ggtggtgact gtggatggcg tgagagtgaa gctgcagatc    300

tgggacaccg ctgggcagga acggttccga agcgtcaccc atgcttatta cagagatgct    360

caggccttgc ttctgctgta tgacatcacc aacaaatctt ctttcgacaa catcagggcc    420

tggctcactg agattcatga gtatgcccag agggacgtgg tgatcatgct gctaggcaac    480

aaggcggata tgagcagcga aagagtgatc cgttccgaag acggagagac cttggccagg    540

gagtacggtg ttcccttcct ggagaccagc gccaagactg gcatgaatgt ggagttagcc    600

tttctggcca tcgccaagga actgaaatac cgggccgggc atcaggcgga tgagcccagc    660

ttccagatcc gagactatgt agagtcccag aagaagcgct ccagctgctg ctccttcatg    720

tgaatcccag ggggcagaga ggaggctctg gaggcacaca ggatgcagcc ttccccctcc    780

caggcctggc ttattccaag aggctgagcc aatggggaga aagatggagg actcactgca    840

cagccgcttc ctagcaggga gctatactcc aactcctact tgagttcctg cggtctcccc    900

gcatccacag ggagggtaaa acacttagct tttattttaa tagtacataa tttaatacca    960

aaaaaggcgc ctggatcccc aaaaaaccga ggctgggagc tagtggccct tttgctttct   1020

aggacttggg gggccggccc tccctcctaa gcataacaaa ggtggtgttg ctccagctca   1080

gccccagggg acacagatgc actttggggg tgagggcagg taatgactcc atcgcaccct   1140

cagttcagct ggacagaggc tcaggtgacc ccagccttca ctgtctcccg ctctccagga   1200

gcttatcttc gccccatctc ccaaataagt gggcccttgt gctgtgagga agaccaaagc   1260

ctcagggaag ataagagata tggagatggg agggggagga caaggggcag agagtagggt   1320

ctagctggct atctctggcc ttactaacac ccccctggag gcatgcccct tttctccagc   1380

acacaagcac attggggcac ctggaaatat tggttccagg ctcctgttct ctggacttca   1440

gatcctgggg gagcccctcc cccccctgaa tccctggctt agctaccttc ctgcctgtgc   1500

acctaaaaac ctcaggtcag aactaggaaa agagttttgt ttttattttt ttgaaatgga   1560

gtctcgttct gtcgcccagg ctgaggtgca gtagtgcaat ctccgctcac tacaacctcc   1620

actccctggg gctcaagcga tcctcccacc tcagccgccg aagtagctgg gactataggt   1680

gtgtaccatc acacctggct aatttttgta ttttttgtag acacagggtt tcgccatgtt   1740

gcccaggctg gtcttgaatt cctgagctca agcaacctgc cggcctcggc ctcccaaagt   1800

actgggatta cacgcagaag gcaccatgcc caggctagat gtgtcttatc ccaatccttt   1860

ggcaggcatg cagctccaca ggcgatttct tcaagcagct gaagtgttta gccctcctgg   1920

gttaagagcc agataaggag aaatcccttt cctaggtttg gaatgtgttg tg           1972


<210>  3579
<211>  223
<212>  PRT
<213>  Homosapiens

<400>  3579

Met Thr Gly Thr Pro Gly Ala Val Ala Thr Arg Asp Gly Glu Ala Pro 
1               5                   10                  15      


Glu Arg Ser Pro Pro Cys Ser Pro Ser Tyr Asp Leu Thr Gly Lys Val 
            20                  25                  30          


Met Leu Leu Gly Asp Thr Gly Val Gly Lys Thr Cys Phe Leu Ile Gln 
        35                  40                  45              


Phe Lys Asp Gly Ala Phe Leu Ser Gly Thr Phe Ile Ala Thr Val Gly 
    50                  55                  60                  


Ile Asp Phe Arg Asn Lys Val Val Thr Val Asp Gly Val Arg Val Lys 
65                  70                  75                  80  


Leu Gln Ile Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Val Thr 
                85                  90                  95      


His Ala Tyr Tyr Arg Asp Ala Gln Ala Leu Leu Leu Leu Tyr Asp Ile 
            100                 105                 110         


Thr Asn Lys Ser Ser Phe Asp Asn Ile Arg Ala Trp Leu Thr Glu Ile 
        115                 120                 125             


His Glu Tyr Ala Gln Arg Asp Val Val Ile Met Leu Leu Gly Asn Lys 
    130                 135                 140                 


Ala Asp Met Ser Ser Glu Arg Val Ile Arg Ser Glu Asp Gly Glu Thr 
145                 150                 155                 160 


Leu Ala Arg Glu Tyr Gly Val Pro Phe Leu Glu Thr Ser Ala Lys Thr 
                165                 170                 175     


Gly Met Asn Val Glu Leu Ala Phe Leu Ala Ile Ala Lys Glu Leu Lys 
            180                 185                 190         


Tyr Arg Ala Gly His Gln Ala Asp Glu Pro Ser Phe Gln Ile Arg Asp 
        195                 200                 205             


Tyr Val Glu Ser Gln Lys Lys Arg Ser Ser Cys Cys Ser Phe Met 
    210                 215                 220             


<210>  3580
<211>  1776
<212>  DNA
<213>  Homosapiens

<400>  3580
ggagatgccc gttcgctcgg gatcaggaac ggtgagctcc tgggaccgca atgccctgag     60

aacgcagccg ggtgctgagc ctccggagtc cggtagctga atgaaatacg cagggatcac    120

cagccggacc caaatcttgc gtccctgcca gcatcctgga gtcctaagag gcagggattg    180

gagcggacag gatctcagaa ctctggtccc gggcgcacaa cggcggagtc gctgttcctg    240

gtgctgaaac gctcagtcct ggaagaacgt ggccgcctgc ccgcctggta ccgcgccgcg    300

gccgctgcgg ggaactgtcc agtgctgaaa acggatgcgg cccggcccgc agagctcaga    360

cccaagcctg ccgcacccag cggagctcga accgagctcc tggaagcgct gacgcagagc    420

gcagggagag ccggagcggc gagctccaag cctggcatgg acctgcagag acccgattcc    480

taccagggag gagctggccc tgacttcaac gaccacgtcc tgcataagac catcctggtg    540

ggtgacagtg gtgtgggaaa gacgtctctg ctggttcagt tcgatcaggg caagttcatc    600

cccggctcct tctcggccac tgtgggcatc ggattcacga acaaggtggt gactgtggat    660

ggcgtgagag tgaagctgca gatctgggac accgctgggc aggaacggtt ccgaagcgtc    720

acccatgctt attacagaga tgctcaggcc ttgcttctgc tgtatgacat caccaacaaa    780

tcttctttcg acaacatcag ggcctggctc actgagattc atgagtatgc ccagagggac    840

gtggtgatca tgctgctagg caacaaggcg gatatgagca gcgaaagagt gatccgttcc    900

gaagacggag agaccttggc cagggagtac ggtgttccct tcctggagac cagcgccaag    960

actggcatga atgtggagtt agcctttctg gccatcgcca aggaactgaa ataccgggcc   1020

gggcatcagg cggatgagcc cagcttccag atccgagact atgtagagtc ccagaagaag   1080

cgctccagct gctgctcctt catgtgaatc ccagggggca gagaggaggc tctggaggca   1140

cacaggatgc agccttcccc cacccatgcc ctttccttta acttctcaaa cagataccag   1200

ggcctaaact gctttacctc ccctcctact gagtcaggtt aggtggtggg aggtcaccca   1260

tttccgagtt aaaccaatgc aatatgagta aaacaaagtc atgtgggtat gtctggggta   1320

gagagagggg tagcaagttc atgtgtcctc cttggtcaca tatctcccaa agctccgatc   1380

cctgccatgg gaagtggaca ggaaacatga ggtcatgacc tgcaggcatc tttactgcag   1440

ctctgccggc ctggaggggg agagggggag gaagaagtat gcgctgcaca tttctgaggc   1500

tactgcattt gctttcaagg cagaaatctt gctctgagca gtcagcggct ccagtttggg   1560

cccgataagg aagttctccg tggcctccct caggcagagc agggaggagg ctgacattgc   1620

cagtctcttc tggggcccaa ggcaggttgc aggagatcca atcccataga cagctctggg   1680

cctcttgcat ttgagttttt cagaattaaa ctgcagtatt ttggaaagca aaaaaaaaaa   1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                             1776


<210>  3581
<211>  216
<212>  PRT
<213>  Homosapiens

<400>  3581

Met Asp Leu Gln Arg Pro Asp Ser Tyr Gln Gly Gly Ala Gly Pro Asp 
1               5                   10                  15      


Phe Asn Asp His Val Leu His Lys Thr Ile Leu Val Gly Asp Ser Gly 
            20                  25                  30          


Val Gly Lys Thr Ser Leu Leu Val Gln Phe Asp Gln Gly Lys Phe Ile 
        35                  40                  45              


Pro Gly Ser Phe Ser Ala Thr Val Gly Ile Gly Phe Thr Asn Lys Val 
    50                  55                  60                  


Val Thr Val Asp Gly Val Arg Val Lys Leu Gln Ile Trp Asp Thr Ala 
65                  70                  75                  80  


Gly Gln Glu Arg Phe Arg Ser Val Thr His Ala Tyr Tyr Arg Asp Ala 
                85                  90                  95      


Gln Ala Leu Leu Leu Leu Tyr Asp Ile Thr Asn Lys Ser Ser Phe Asp 
            100                 105                 110         


Asn Ile Arg Ala Trp Leu Thr Glu Ile His Glu Tyr Ala Gln Arg Asp 
        115                 120                 125             


Val Val Ile Met Leu Leu Gly Asn Lys Ala Asp Met Ser Ser Glu Arg 
    130                 135                 140                 


Val Ile Arg Ser Glu Asp Gly Glu Thr Leu Ala Arg Glu Tyr Gly Val 
145                 150                 155                 160 


Pro Phe Leu Glu Thr Ser Ala Lys Thr Gly Met Asn Val Glu Leu Ala 
                165                 170                 175     


Phe Leu Ala Ile Ala Lys Glu Leu Lys Tyr Arg Ala Gly His Gln Ala 
            180                 185                 190         


Asp Glu Pro Ser Phe Gln Ile Arg Asp Tyr Val Glu Ser Gln Lys Lys 
        195                 200                 205             


Arg Ser Ser Cys Cys Ser Phe Met 
    210                 215     


<210>  3582
<211>  1794
<212>  DNA
<213>  Homosapiens

<400>  3582
aagttcaagg gcgagagtga gtaccagcag aaggctggga gtctgtagtt tgttcctgct     60

gccaggctcc actgagggga acggggacct gtctgaagag aagatgcccc tgctgacact    120

ctacctgctc ctcttctggc tctcaggcta ctccattgtc actcaaatca ccggtccaac    180

aacagtgaat ggcttggagc ggggctcctt gaccgtgcag tgtgtttaca gatcaggctg    240

ggagacctac ttgaagtggt ggtgtcgagg agctatttgg cgtgactgca agatccttgt    300

taaaaccagt gggtcagagc aggaggtgaa gagggaccgg gtgtccatca aggacaatca    360

gaaaaaccgc acgttcactg tgaccatgga ggatctcatg aaaactgatg ctgacactta    420

ctggtgtgga attgagaaaa ctggaaatga ccttggggtc acagttcaag tgaccattga    480

cccagcacca gtcacccaag aagaaactag cagctcccca actctgaccg gccaccactt    540

ggacaacagg cacaagctcc tgaagctcag tgtcctcctg cccctcatct tcaccatatt    600

gctgctgctt ttggtggccg cctcactctt ggcttggagg atgatgaagt accagcagaa    660

agcagccggg atgtccccag agcaggtact gcagcccctg gagggcgacc tctgctatgc    720

agacctgacc ctgcagctgg ccggaacctc cccgcaaaag gctaccacga agctttcctc    780

tgcccaggtt gaccaggtgg aagtggaata tgtcaccatg gcttccttgc cgaaggagga    840

catttcctat gcatctctga ccttgggtgc tgaggatcag gaaccgacct actgcaacat    900

gggccacctc agtagccacc tccccggcag gggccctgag gagcccacgg aatacagcac    960

catcagcagg ccttagcctg cactccaggc tccttcttgg accccaggct gtgagcacac   1020

tcctgcctca tcgaccgtct gccccctgct cccctcatca ggaccaaccc ggggactggt   1080

gcctctgcct gatcagccag cattgcccct agctctgggt tgggcttggg gccaagtctc   1140

agggggcttc taggagttgg ggttttctaa acgtcccctc ctctcctaca tagttgagga   1200

gggggctagg gatatgctct ggggctttca tgggaatgat gaagatgata atgagaaaaa   1260

tgttatcatt attatcatga agtaccatta tcgtaataca atgaaccttt atttattgcc   1320

taccacatgt tatgggctga ataatggccc ccaaagatat ctgtgtccta atcctcagaa   1380

cctgtgactg ttaccttctg tggcagaaag ggacagtgca gatgtatgta agttaaggac   1440

tttgagatag agaggttatt cttgctgatt caggtgggcc caaaatatca ccacaagggt   1500

cctcataaga aagaggccag aaggtcaaag aggtagagac aaagtgatga tggaagtgga   1560

cgtgggtgtg acgtgagcag gggccatgaa tgccgcagcc ttcagatgcc agaaagggaa   1620

aggaatggat tcccctgcct ggagcctcca aaagaaacca gccctgccca cgccttgact   1680

tgagcccatt gaaactgatc ttgagctcct ggcctccaga attgcaggag aataaatttg   1740

tgttgttttt aatgagccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa         1794


<210>  3583
<211>  290
<212>  PRT
<213>  Homosapiens

<400>  3583

Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr 
1               5                   10                  15      


Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu 
            20                  25                  30          


Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr 
        35                  40                  45              


Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile 
    50                  55                  60                  


Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val 
65                  70                  75                  80  


Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu 
                85                  90                  95      


Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys 
            100                 105                 110         


Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala 
        115                 120                 125             


Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His 
    130                 135                 140                 


His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro 
145                 150                 155                 160 


Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu 
                165                 170                 175     


Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro 
            180                 185                 190         


Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu 
        195                 200                 205             


Thr Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu 
    210                 215                 220                 


Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala 
225                 230                 235                 240 


Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala 
                245                 250                 255     


Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His 
            260                 265                 270         


Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser 
        275                 280                 285             


Arg Pro 
    290 


<210>  3584
<211>  2000
<212>  DNA
<213>  Homosapiens

<400>  3584
cttggcacga gggattggtc tgtgctcctc tctcggctcc tcgcggctcg cggcggccga     60

cggttcctgg gacacctgct tgcttggccc gtccggcggc tcagggcttc tctgctgcgc    120

tcccggttcg ctggacggga agaagggctg ggccgtcccg tcccgtcccc atcggaaccc    180

caagtcgcgc cgctgacccg tcgcagggcg agatgagcgc ggacgcagcg gccggggcgc    240

ccctgccccg gctctgctgc ctggagaagg gtccgaacgg ctacggcttc cacctgcacg    300

gggagaaggg caagttgggc cagtacatcc ggctggtgga gcccggctcg ccggccgaga    360

aggcggggct gctggcgggg gaccggctgg tggaggtgaa cggcgaaaac gtggagaagg    420

agacccacca gcaggtggtg agccgcatcc gcgccgcact caacgccgtg cgcctgctgg    480

tggtcgaccc cgagacggac gagcagctgc agaagctcgg cgtccaggtc cgagaggagc    540

tgctgcgcgc ccaggaagcg ccggggcagg ccgagccgcc ggccgccgcc gaggtgcagg    600

gggctggcaa cgaaaatgag cctcgcgagg ccgacaagag ccacccggag cagcgcgagc    660

ttcggcctcg gctctgtacc atgaagaagg gccccagtgg ctatggcttc aacctgcaca    720

gcgacaagtc caagccaggc cagttcatcc ggtcagtgga cccagactcc ccggctgagg    780

cttcagggct ccgggcccag gatcgcattg tggaggtgaa cggggtctgc atggagggga    840

agcagcatgg ggacgtggtg tccgccatca gggctggcgg ggacgagacc aagctgctgg    900

tggtggacag ggaaactgac gagttcttca agaaatgcag agtgatccca tctcaggagc    960

acctgaatgg tcccctgcct gtgcccttca ccaatgggga gatacagaag gagaacagtc   1020

gtgaagccct ggcagaggca gccttggaga gccccaggcc agccctggtg agatccgcct   1080

ccagtgacac cagcgaggag ctgaattccc aagacagccc cccaaaacag gactccacag   1140

cgccctcgtc tacctcctcc tccgacccca tcctagactt caacatctcc ctggccatgg   1200

ccaaagagag ggcccaccag aaacgcagca gcaaacgggc cccgcagatg gactggagca   1260

agaaaaacga actcttcagc aacctctgag cgccctgctg ccacccagtg actggcaggg   1320

ccgagccagc attccacccc acctttttcc ttctccccaa ttactcccct gaatcaatgt   1380

acaaatcagc acccacatcc cctttcttga caaatgattt ttctagagaa ctatgttctt   1440

ccctgacttt agggaaggtg aatgtgttcc cgtcctcccg cagtcagaaa ggagactctg   1500

cctccctcct cctcactgag tgcctcatcc taccgggtgt ccctttgcca ccctgcctgg   1560

gacatcgctg gaacctgcac catgccagga tcatgggacc aggcgagagg gcaccctccc   1620

ttcctccccc atgtgataaa tgggtccagg gctgatcaaa gaactctgac tgcagaactg   1680

ccgctctcag tggacagggc atctgttatc ctgaaccttg gcagacacgt cttgttttca   1740

tttgattttg ttaagagtgc agtattgcag agtctagagg aatttttgtt tccttgatta   1800

acatgatttt cctggttgtt aatccagggc atggcagtgg cctcagcctt aaacttttgt   1860

tcctactccc accctcagcg aactgggcag cacggggagg gtttggctac ccctgcccat   1920

ccctgagcca ggtaccacca ttgtaaggaa acactttcag aaattcagct ggttcctcca   1980

aaccaaaaaa aaaaaaaaaa                                               2000


<210>  3585
<211>  358
<212>  PRT
<213>  Homosapiens

<400>  3585

Met Ser Ala Asp Ala Ala Ala Gly Ala Pro Leu Pro Arg Leu Cys Cys 
1               5                   10                  15      


Leu Glu Lys Gly Pro Asn Gly Tyr Gly Phe His Leu His Gly Glu Lys 
            20                  25                  30          


Gly Lys Leu Gly Gln Tyr Ile Arg Leu Val Glu Pro Gly Ser Pro Ala 
        35                  40                  45              


Glu Lys Ala Gly Leu Leu Ala Gly Asp Arg Leu Val Glu Val Asn Gly 
    50                  55                  60                  


Glu Asn Val Glu Lys Glu Thr His Gln Gln Val Val Ser Arg Ile Arg 
65                  70                  75                  80  


Ala Ala Leu Asn Ala Val Arg Leu Leu Val Val Asp Pro Glu Thr Asp 
                85                  90                  95      


Glu Gln Leu Gln Lys Leu Gly Val Gln Val Arg Glu Glu Leu Leu Arg 
            100                 105                 110         


Ala Gln Glu Ala Pro Gly Gln Ala Glu Pro Pro Ala Ala Ala Glu Val 
        115                 120                 125             


Gln Gly Ala Gly Asn Glu Asn Glu Pro Arg Glu Ala Asp Lys Ser His 
    130                 135                 140                 


Pro Glu Gln Arg Glu Leu Arg Pro Arg Leu Cys Thr Met Lys Lys Gly 
145                 150                 155                 160 


Pro Ser Gly Tyr Gly Phe Asn Leu His Ser Asp Lys Ser Lys Pro Gly 
                165                 170                 175     


Gln Phe Ile Arg Ser Val Asp Pro Asp Ser Pro Ala Glu Ala Ser Gly 
            180                 185                 190         


Leu Arg Ala Gln Asp Arg Ile Val Glu Val Asn Gly Val Cys Met Glu 
        195                 200                 205             


Gly Lys Gln His Gly Asp Val Val Ser Ala Ile Arg Ala Gly Gly Asp 
    210                 215                 220                 


Glu Thr Lys Leu Leu Val Val Asp Arg Glu Thr Asp Glu Phe Phe Lys 
225                 230                 235                 240 


Lys Cys Arg Val Ile Pro Ser Gln Glu His Leu Asn Gly Pro Leu Pro 
                245                 250                 255     


Val Pro Phe Thr Asn Gly Glu Ile Gln Lys Glu Asn Ser Arg Glu Ala 
            260                 265                 270         


Leu Ala Glu Ala Ala Leu Glu Ser Pro Arg Pro Ala Leu Val Arg Ser 
        275                 280                 285             


Ala Ser Ser Asp Thr Ser Glu Glu Leu Asn Ser Gln Asp Ser Pro Pro 
    290                 295                 300                 


Lys Gln Asp Ser Thr Ala Pro Ser Ser Thr Ser Ser Ser Asp Pro Ile 
305                 310                 315                 320 


Leu Asp Phe Asn Ile Ser Leu Ala Met Ala Lys Glu Arg Ala His Gln 
                325                 330                 335     


Lys Arg Ser Ser Lys Arg Ala Pro Gln Met Asp Trp Ser Lys Lys Asn 
            340                 345                 350         


Glu Leu Phe Ser Asn Leu 
        355             


<210>  3586
<211>  1943
<212>  DNA
<213>  Homosapiens

<400>  3586
gggaacgtgg ctggttggag gaggtagatc accctttctg cgggggacga tttcgtcggt     60

ggtaggctgc taccatgagg ttgaatcaga acaccttgct gctggggaag aaggtggtcc    120

ttgtacccta cacctcggag catgtgccca gcaggtacca cgagtggatg aaatcagagg    180

agctgcagcg tttgacagcc tcggagccgc tgaccctgga gcaggagtat gccatgcagt    240

gcagctggca ggaagatgca gacaagtgta ccttcattgt gctggatgcc gagaagtggc    300

aggcccagcc aggcgccacc gaagagagct gcatggtggg agatgtgaac ctcttcctca    360

cagatctaga agacctcacc ttgggggaga tcgaggtcat gattgcagag cccagctgca    420

ggggtaaggg ccttggcact gaggccgttc tcgcgatgct gtcttacgga gtgaccacgc    480

taggtctgac caagtttgag gctaaaattg ggcaaggaaa tgaaccaagc atccggatgt    540

tccagaaact tcactttgag caggtggcta cgagcagtgt ttttcaggag gtgaccctca    600

gactgacagt gagtgagtcc gagcatcagt ggcttctgga gcagaccagc cacgtggaag    660

agaagcctta cagagatggg tcggcagagc cctgctgatg gctgggcctt gtgggcagcc    720

actctgtgtg agcagggtgt tgggcccata cacttcaaag accagagccc tgcactggga    780

gagtgctcct ggcccaggct gggaatcacc tttcgaggcc cttcagactc tggcggggct    840

tgctgtggcc tccctccagc tagtggtgtg gctgagcaga ctccagggcc agggccagtt    900

cccttctccc ctcccggcca aacccagacc cagactctag gaagctggaa tggagggcag    960

ggatccatgg gagatgtcgg gatgaaggtg ggagctggag gtgcaggggg acctggaaca   1020

tggatgggag tggacaggcc tttctcctta gaggccagag gtgctgccct ggctgggagt   1080

gaagctccag gcactaccag ctttcctgat tttcccgttt ggtccatgtg aagagctacc   1140

acgagcccca gcctcacagt gtccactcaa gggcagcttg gtcctcttgt cctgcagagg   1200

caggctggtg tgaccctggg aacttgaccc gggaacaaca ggtggtccag agtgagtgtg   1260

gcctggcccc tcaacctagt gtccgtcctc ctctctcctg gagccagtct tgagtttaaa   1320

ggcattagtg ttagatacag ctccttgtgg ctggaaaaca cccctctgct gataaagctc   1380

agggggcact gaggaagcag aggccccttg ggggtgccct cctgaagaga gcgtcaggcc   1440

atcagctctg tccctctggt gctcccacgt ctgttcctca ccctccatct ctgggagcag   1500

ctgcacctga ctggccacgc gggggcagtg gaggcacagg ctcagggtgg ccgggctacc   1560

tggcacccta tggcttacaa agtagagttg gcccagtttc cttccacctg aggggagcac   1620

tctgactcct aacagtcttc cttgccctgc catcatctgg ggtggctggc tgtcaagaaa   1680

ggccgggcat gctttctaaa cacagccaca ggaggcttgt agggcatctt ccaggtgggg   1740

aaacagtctt agataagtaa ggtgacttgc ctaaggcctc ccagcaccct tgatcttgga   1800

gtctcacagc agactgcatg tgaacaactg gaaccgaaaa catgcctcag tataaaacaa   1860

acattataaa acgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1920

aaaaaaaaaa aaaaaaaaaa aaa                                           1943


<210>  3587
<211>  207
<212>  PRT
<213>  Homosapiens

<400>  3587

Met Arg Leu Asn Gln Asn Thr Leu Leu Leu Gly Lys Lys Val Val Leu 
1               5                   10                  15      


Val Pro Tyr Thr Ser Glu His Val Pro Ser Arg Tyr His Glu Trp Met 
            20                  25                  30          


Lys Ser Glu Glu Leu Gln Arg Leu Thr Ala Ser Glu Pro Leu Thr Leu 
        35                  40                  45              


Glu Gln Glu Tyr Ala Met Gln Cys Ser Trp Gln Glu Asp Ala Asp Lys 
    50                  55                  60                  


Cys Thr Phe Ile Val Leu Asp Ala Glu Lys Trp Gln Ala Gln Pro Gly 
65                  70                  75                  80  


Ala Thr Glu Glu Ser Cys Met Val Gly Asp Val Asn Leu Phe Leu Thr 
                85                  90                  95      


Asp Leu Glu Asp Leu Thr Leu Gly Glu Ile Glu Val Met Ile Ala Glu 
            100                 105                 110         


Pro Ser Cys Arg Gly Lys Gly Leu Gly Thr Glu Ala Val Leu Ala Met 
        115                 120                 125             


Leu Ser Tyr Gly Val Thr Thr Leu Gly Leu Thr Lys Phe Glu Ala Lys 
    130                 135                 140                 


Ile Gly Gln Gly Asn Glu Pro Ser Ile Arg Met Phe Gln Lys Leu His 
145                 150                 155                 160 


Phe Glu Gln Val Ala Thr Ser Ser Val Phe Gln Glu Val Thr Leu Arg 
                165                 170                 175     


Leu Thr Val Ser Glu Ser Glu His Gln Trp Leu Leu Glu Gln Thr Ser 
            180                 185                 190         


His Val Glu Glu Lys Pro Tyr Arg Asp Gly Ser Ala Glu Pro Cys 
        195                 200                 205         


<210>  3588
<211>  3413
<212>  DNA
<213>  Homosapiens

<400>  3588
agcgggactg gcgggagacg gcggcttgcg agctggctgt gctgcaggag ctgcggcagc     60

cgccgtcctt gcacctaagg aacctctgct gccagccctt cctcactttt ggaaatggcg    120

ggtgaaatta cagagaccgg ggaactctac tcttcctacg ttgggctggt gtacatgttt    180

aacctcatcg tgggcacggg cgcactcacc atgcccaagg cattcgccac tgccgggtgg    240

cttgtcagcc tcgtcctgct ggtgttcctg ggcttcatga gcttcatgac caccaccttt    300

gtgatagagg ccatggctgc agccaacgcg cagctccact ggaagaggat ggagaacctc    360

aaggaggagg aagatgacga ctcctccaca gcctcagaca gcgatgttct catccgggac    420

aactacgagc gggcagagaa gcggcccatc ctgtctgtgc agagacgtgg atctcccaac    480

ccgtttgaaa tcacagaccg ggtggaaatg ggacaaatgg cctccatgtt cttcaataaa    540

gtgggggtca acttgttcta tttctgcatc atcgtttatc tgtatggaga cctcgccatc    600

tatgctgctg ccgtgccctt ctccctcatg caggtgacct gcagcgccac tggcaatgac    660

tcctgcggtg tggaagcaga caccaaatac aatgacactg accggtgttg ggggcccctg    720

cgccgagtgg acgcctaccg catctacttg gcgatcttca ctctcctcct cggaccgttc    780

accttctttg acgtccagaa gaccaagtac ctgcagatcc tgacctctct gatgagatgg    840

atcgctttcg ccgtcatgat tgtgctggcc ctgatccgca tcgggcacgg acaaggggag    900

gggcacccgc ccctggctga cttctcgggg gtccggaacc tgtttggggt gtgcgtctac    960

tccttcatgt gccagcactc tctgccatcc ctcattaccc ccgtctcctc caagcgccac   1020

ctcacaaggc tggtgttcct ggactacgtg ctgatcctgg ccttctacgg cctcctctcc   1080

ttcaccgcca tcttctgctt ccgcggcgac agcctcatgg acatgtacac cctcaacttc   1140

gcgcgctgtg acgtcgtggg cctggccgct gtgcgctttt tcctgggcct cttccccgtc   1200

ttcaccatca gcaccaactt ccccatcatt gccgtgaccc tgcgcaacaa ctggaagaca   1260

ctcttccacc gcgagggcgg cacgtacccg tgggtggtgg accgcgtcgt gtttcccacc   1320

atcaccctgg tgccgcctgt gctggtggcc ttctgcaccc acgacctgga gtccctggtg   1380

ggcatcacag gggcctacgc gggcaccggc atccagtacg tcatccccgc cttcctggtg   1440

taccactgcc gcagggacac ccagctggcc tttggctgtg gggtcagcaa caagcacagg   1500

tcccctttcc gccacacctt ctgggtgggc ttcgtgctgc tctgggcttt ctcctgcttc   1560

attttcgtca cggccaatat catcctcagc gagaccaagc tctgatggca ggacaggcag   1620

gtctagtgac aggaggcata ggggccccag ccccacccct cgcccgcaga gcccagattt   1680

agttgctccc aggtcttcat ggggcaggtg ggactgtggc tctaggggaa accccctgtc   1740

cagctggggt tgttctcccc acccaccttc cacccagtct gcacctgtcc tcactccccc   1800

gggcagctct cccaccaggt ccttctgcct gggtgacgcg tggctgctcc caagttctaa   1860

gactcattac tggaatcaca cctctcccac atcttccaac acgcttcacc cccaacccta   1920

cttccagggc gggctactcc ctgcacaatg ggagatgcag tgctggcact gccatcattt   1980

gtcccagacc catgcccctc ccctctcctg ccccatcctg cgtccttgtc taagaaacct   2040

ccactagcag ctgctgcctc ttcagaggcg aatcccaggc tggaagtatc ctagccaggt   2100

ctgcctgtga cggcagggcc caccctccca ccaggcctgg gaggcggtag gtgccacctc   2160

agagagggcc tggctggccc catgacaaga acaagaagtg ctaactggta ccagagtccc   2220

cagatagagc tgcgagggcc ctcgctgtgg gcgcgagctc cggagtagca ggctggatgg   2280

agcatccctt ctacagggac acggccgcct gccagctggg cctaaagtct ggagcttgtc   2340

tctgaaaggg accgtctgct gccctcgctg ccccactgga gccctcaggg cctcctacag   2400

tgcaggtggt cctactagag ggaagccatc cccacctggc acctcagcgg cttggcagtg   2460

acatggcagt gggagggctc tgaggttccc accctgacaa tggtcaggct gcccgtgctc   2520

ccactccaac actaaaagcg gctcccttag gggctgagcg tgggtgctca gtgttcacgc   2580

tatatccctt gggcaatgtg gggttggatg gggcccccac ttccattccc atggaaggag   2640

gccaggtccc cagccacctc ccactcagcc atgcacgcac ttgctgggct ggcctcctgg   2700

gaaacacagg tgactcgaat gaactctgca ttttcaacgt gccttctact gcttcaggac   2760

ctgggggtcc ccctgaccct cactggcttg cccccagccc tgggcctggc cccacctgtc   2820

ctggagccca gagcccctgg cctggagctg cctctctggg gtgggtctca ggccccaccc   2880

ctccctcttt tgagttcagt gccttgctca gcccctcccc tgtatctcag cgtcttgaga   2940

cctctgacag agcgacgatg tagggtctcc cggggcccaa ggtggtctca gggtcagggg   3000

tgggatttgc agggaactcg gggagcccac gggctgcgcc acctctgccc tggcagctga   3060

agcctgggag agtccctgcg tggtgtaatt ggcctcagcc cgctttctct gtgccgtcgc   3120

acctcagtgt ttctcatagc ttgtccccac gtgtcacttt ccatccacgg gaaaaacaaa   3180

tgccccttct ccatctatca ttgcgacttc ctcccaggag gcctctcagg ttgggtagag   3240

caggggcctg cagtggtcag gccaagagca aggaagacct ggctgcccca ctgtggctga   3300

aaactcaaaa catctggaac tacccttctc caattacgtt ccctcttgct taaagacaaa   3360

gctaattaaa tcatcctgcc acccgaggct ccaaaccaaa aaaaaaaaaa aaa          3413


<210>  3589
<211>  496
<212>  PRT
<213>  Homosapiens

<400>  3589

Met Ala Gly Glu Ile Thr Glu Thr Gly Glu Leu Tyr Ser Ser Tyr Val 
1               5                   10                  15      


Gly Leu Val Tyr Met Phe Asn Leu Ile Val Gly Thr Gly Ala Leu Thr 
            20                  25                  30          


Met Pro Lys Ala Phe Ala Thr Ala Gly Trp Leu Val Ser Leu Val Leu 
        35                  40                  45              


Leu Val Phe Leu Gly Phe Met Ser Phe Met Thr Thr Thr Phe Val Ile 
    50                  55                  60                  


Glu Ala Met Ala Ala Ala Asn Ala Gln Leu His Trp Lys Arg Met Glu 
65                  70                  75                  80  


Asn Leu Lys Glu Glu Glu Asp Asp Asp Ser Ser Thr Ala Ser Asp Ser 
                85                  90                  95      


Asp Val Leu Ile Arg Asp Asn Tyr Glu Arg Ala Glu Lys Arg Pro Ile 
            100                 105                 110         


Leu Ser Val Gln Arg Arg Gly Ser Pro Asn Pro Phe Glu Ile Thr Asp 
        115                 120                 125             


Arg Val Glu Met Gly Gln Met Ala Ser Met Phe Phe Asn Lys Val Gly 
    130                 135                 140                 


Val Asn Leu Phe Tyr Phe Cys Ile Ile Val Tyr Leu Tyr Gly Asp Leu 
145                 150                 155                 160 


Ala Ile Tyr Ala Ala Ala Val Pro Phe Ser Leu Met Gln Val Thr Cys 
                165                 170                 175     


Ser Ala Thr Gly Asn Asp Ser Cys Gly Val Glu Ala Asp Thr Lys Tyr 
            180                 185                 190         


Asn Asp Thr Asp Arg Cys Trp Gly Pro Leu Arg Arg Val Asp Ala Tyr 
        195                 200                 205             


Arg Ile Tyr Leu Ala Ile Phe Thr Leu Leu Leu Gly Pro Phe Thr Phe 
    210                 215                 220                 


Phe Asp Val Gln Lys Thr Lys Tyr Leu Gln Ile Leu Thr Ser Leu Met 
225                 230                 235                 240 


Arg Trp Ile Ala Phe Ala Val Met Ile Val Leu Ala Leu Ile Arg Ile 
                245                 250                 255     


Gly His Gly Gln Gly Glu Gly His Pro Pro Leu Ala Asp Phe Ser Gly 
            260                 265                 270         


Val Arg Asn Leu Phe Gly Val Cys Val Tyr Ser Phe Met Cys Gln His 
        275                 280                 285             


Ser Leu Pro Ser Leu Ile Thr Pro Val Ser Ser Lys Arg His Leu Thr 
    290                 295                 300                 


Arg Leu Val Phe Leu Asp Tyr Val Leu Ile Leu Ala Phe Tyr Gly Leu 
305                 310                 315                 320 


Leu Ser Phe Thr Ala Ile Phe Cys Phe Arg Gly Asp Ser Leu Met Asp 
                325                 330                 335     


Met Tyr Thr Leu Asn Phe Ala Arg Cys Asp Val Val Gly Leu Ala Ala 
            340                 345                 350         


Val Arg Phe Phe Leu Gly Leu Phe Pro Val Phe Thr Ile Ser Thr Asn 
        355                 360                 365             


Phe Pro Ile Ile Ala Val Thr Leu Arg Asn Asn Trp Lys Thr Leu Phe 
    370                 375                 380                 


His Arg Glu Gly Gly Thr Tyr Pro Trp Val Val Asp Arg Val Val Phe 
385                 390                 395                 400 


Pro Thr Ile Thr Leu Val Pro Pro Val Leu Val Ala Phe Cys Thr His 
                405                 410                 415     


Asp Leu Glu Ser Leu Val Gly Ile Thr Gly Ala Tyr Ala Gly Thr Gly 
            420                 425                 430         


Ile Gln Tyr Val Ile Pro Ala Phe Leu Val Tyr His Cys Arg Arg Asp 
        435                 440                 445             


Thr Gln Leu Ala Phe Gly Cys Gly Val Ser Asn Lys His Arg Ser Pro 
    450                 455                 460                 


Phe Arg His Thr Phe Trp Val Gly Phe Val Leu Leu Trp Ala Phe Ser 
465                 470                 475                 480 


Cys Phe Ile Phe Val Thr Ala Asn Ile Ile Leu Ser Glu Thr Lys Leu 
                485                 490                 495     


<210>  3590
<211>  4298
<212>  DNA
<213>  Homosapiens

<400>  3590
catcgcgagt gtccttgagc cgcgggtgac ggtggctctc gctgctcgcg ccccctcctc     60

ccgcgggggg agcctgatgc cacgttccct atgaattatt tatcgccggc ctaaaaatac    120

cccgaacttc acagcccgag tgaccctccg gtggacatgg gtggggccct ggggccggcc    180

ctgttgctca cctcgctctt cggtgcctgg gcagggctgg gtccggggca gggcgagcag    240

ggcatgacgg tggccgtggt gtttagcagc tcagggccgc cccaggccca gttccgtgcc    300

cgcctcaccc cccagagctt cctggaccta cccctggaga tccagccgct cacagttggg    360

gtcaacacca ccaaccccag cagcctcctc acccagatct gcggcctcct gggtgctgcc    420

cacgtccacg gcattgtctt tgaggacaac gtggacaccg aggcggtggc ccagatcctt    480

gacttcatct cctcccagac ccatgtgccc atcctcagca tcagcggagg ctctgctgtg    540

gtcctcaccc ccaaggagcc gggctccgcc ttcctgcagc tgggcgtgtc cctggagcag    600

cagctgcagg tgctgttcaa ggtgctggaa gagtacgact ggagcgcctt cgccgtcatc    660

accagcctgc acccgggcca cgcgctcttc ctggagggcg tgcgcgccgt cgccgacgcc    720

agccacgtga gttggcggct gctggacgtg gtcacgctgg agctgggccc gggagggccg    780

cgcgcgcgca cgcagcgcct gctgcgccag ctcgacgcgc ccgtgtttgt ggcctactgc    840

tcgcgcgagg aggccgaggt gctcttcgcc gaggcggcgc aggccggtct ggtggggccc    900

ggccacgtgt ggctggtgcc caacctggcg ctgggcagca ccgatgcgcc ccccgccacc    960

ttccccgtgg gcctcatcag cgtcgtcacc gagagctggc gcctcagcct gcgccagaag   1020

gtgcgcgacg gcgtggccat tctggccctg ggcgcccaca gctactggcg ccagcatgga   1080

accctgccag ccccggccgg ggactgccgt gttcaccctg ggcccgtcag ccctgcccgg   1140

gaggccttct acaggcacct actgaatgtc acctgggagg gccgagactt ctccttcagc   1200

cctggtgggt acctggtcca gcccaccatg gtggtgatcg ccctcaaccg gcaccgcctc   1260

tgggagatgg tggggcgctg ggagcatggc gtcctataca tgaagtaccc cgtgtggcct   1320

cgctacagtg cctctctgca gcctgtggtg gacagtcggc acctgacggt ggccacgctg   1380

gaagagcggc cctttgtcat cgtggagagc cctgaccctg gcacaggagg ctgtgtcccc   1440

aacaccgtgc cctgccgcag gcagagcaac cacaccttca gcagcgggga cgtggccccc   1500

tacaccaagc tctgctgtaa gggattctgc atcgacatcc tcaagaagct ggccagagtg   1560

gtcaaattct cctacgacct gtacctggtg accaacggca agcatggcaa gcgggtgcgc   1620

ggcgtatgga acggcatgat tggggaggtg tactacaagc gggcagacat ggccatcggc   1680

tccctcacca tcaatgagga acgctccgag atcgtagact tctctgtacc ctttgtggag   1740

acgggcatca gtgtgatggt ggctcgcagc aatggcaccg tctccccctc ggccttcttg   1800

gagccatata gccctgcagt gtgggtgatg atgtttgtca tgtgcctcac tgtggtggcc   1860

atcaccgtct tcatgttcga gtacttcagc cctgtcagct acaaccagaa cctcaccaga   1920

ggcaagaagt ccgggggccc agctttcact atcggcaagt ccgtgtggct gctgtgggcg   1980

ctggtcttca acaactcagt gcccatcgag aacccgcggg gcaccaccag caagatcatg   2040

gttctggtct gggccttctt tgctgtcatc ttcctcgcca gctacacggc caacctggcc   2100

gccttcatga tccaagagca atacatcgac actgtgtcgg gcctcagtga caagaagttt   2160

cagcggcctc aagatcagta cccacctttc cgcttcggca cggtgcccaa cggcagcacg   2220

gagcggaaca tccgcagtaa ctaccgtgac atgcacaccc acatggtcaa gttcaaccag   2280

cgctcggtgg aggacgcgct caccagcctc aagatgggga agctggatgc cttcatctat   2340

gatgctgctg tcctcaacta catggcaggc aaggacgagg gctgcaagct ggtcaccatt   2400

gggtctggca aggtctttgc taccactggc tacggcatcg ccatgcagaa ggactcccac   2460

tggaagcggg ccatagacct ggcgctcttg cagttcctgg gggacggaga gacacagaaa   2520

ctggagacag tgtggctctc agggatctgc cagaatgaga agaacgaggt gatgagcagc   2580

aagctggaca tcgacaacat ggcaggcgtc ttctacatgc tgctggtggc catggggctg   2640

gccctgctgg tcttcgcctg ggagcacctg gtctactgga agctgcgcca ctcggtgccc   2700

aactcatccc agctggactt cctgctggct ttcagcaggg gcatctacag ctgcttcagc   2760

ggggtgcaga gcctcgccag cccaccgcgg caggccagcc cggacctcac ggccagctcg   2820

gcccaggcca gcgtgctcaa gatgctgcag gcagcccgcg acatggtgac cacggcgggc   2880

gtaagcagct ccctggaccg cgccactcgc accatcgaga attggggtgg cggccgccgt   2940

gcgcccccac cgtccccctg cccgaccccg cggtctggcc ccagcccatg cctgcccacc   3000

cccgacccgc ccccagagcc gagccccacg ggctggggac cgccagacgg gggtcgcgcg   3060

gcgcttgtgc gcagggctcc gcagcccccg ggccgccccc cgacgccggg gccgcccctg   3120

tccgacgtct cccgagtgtc gcgccgccca gcctgggagg cgcggtggcc ggtgcggacc   3180

gggcactgcg ggaggcacct ctcggcctcc gagcggcccc tgtcgcccgc gcgctgtcac   3240

tacagctcct ttcctcgagc cgaccgatcc ggccgcccct tcctcccgct cttcccggag   3300

ctggaggacc tgccgctgct cggtccggag cagctggccc ggcgggaggc cctgctgcac   3360

gcggcctggg cccggggctc gcgcccgcgt cacgcttccc tgcccagctc cgtggccgag   3420

gccttcgctc ggcccagctc gctgcccgct gggtgcaccg gccccgcctg cgcccgcccc   3480

gacggccact cggcctgcag gcgcttggcg caggcgcagt cgatgtgctt gccgatctac   3540

cgggaggcct gccaggaggg cgagcaggca ggggcccccg cctggcagca cagacagcac   3600

gtctgcctgc acgcccacgc ccacctgcca ttttgctggg gggctgtctg tcctcacctt   3660

ccaccctgtg ccagccacgg ctcctggctc tccggggcct gggggcctct ggggcacagg   3720

ggcaggactc tggggctggg cacaggctac agagacagtg ggggactgga cgagatcagc   3780

agggtagccc gtgggacgca aggcttcccg ggaccctgca cctggagacg gatctccagt   3840

ctggagtcag aagtgtgagt tatcagccac tcaggctccg agccagctgg attctctgcc   3900

tgccactgtc agggttaagc ggcaggcagg attgggcttt tctggcttct accatgaaat   3960

cctggccatg ggaccccagt gacagatgat gtcttccatg gtcatcagtg acctcagtag   4020

cctcaaatca tggtgagggc tgggcttttg ctgtcctctt ctcacgcaga gttctgccag   4080

gagggtgtgc tgtgggggtc agactcctga ggctctccct tccctggggc tagccagtta   4140

ctggtcatgg ctgctgtggg catggaggct ggaacttgtg gttgaggcag ggccatcccg   4200

atccttgctc tacctggcta gagtttcttc tcatcagagc actgggacat taaacccacc   4260

ttttcccaga aaaaaaaaaa aaaaaaaaaa aaaaaaaa                           4298


<210>  3591
<211>  1233
<212>  PRT
<213>  Homosapiens

<400>  3591

Met Gly Gly Ala Leu Gly Pro Ala Leu Leu Leu Thr Ser Leu Phe Gly 
1               5                   10                  15      


Ala Trp Ala Gly Leu Gly Pro Gly Gln Gly Glu Gln Gly Met Thr Val 
            20                  25                  30          


Ala Val Val Phe Ser Ser Ser Gly Pro Pro Gln Ala Gln Phe Arg Ala 
        35                  40                  45              


Arg Leu Thr Pro Gln Ser Phe Leu Asp Leu Pro Leu Glu Ile Gln Pro 
    50                  55                  60                  


Leu Thr Val Gly Val Asn Thr Thr Asn Pro Ser Ser Leu Leu Thr Gln 
65                  70                  75                  80  


Ile Cys Gly Leu Leu Gly Ala Ala His Val His Gly Ile Val Phe Glu 
                85                  90                  95      


Asp Asn Val Asp Thr Glu Ala Val Ala Gln Ile Leu Asp Phe Ile Ser 
            100                 105                 110         


Ser Gln Thr His Val Pro Ile Leu Ser Ile Ser Gly Gly Ser Ala Val 
        115                 120                 125             


Val Leu Thr Pro Lys Glu Pro Gly Ser Ala Phe Leu Gln Leu Gly Val 
    130                 135                 140                 


Ser Leu Glu Gln Gln Leu Gln Val Leu Phe Lys Val Leu Glu Glu Tyr 
145                 150                 155                 160 


Asp Trp Ser Ala Phe Ala Val Ile Thr Ser Leu His Pro Gly His Ala 
                165                 170                 175     


Leu Phe Leu Glu Gly Val Arg Ala Val Ala Asp Ala Ser His Val Ser 
            180                 185                 190         


Trp Arg Leu Leu Asp Val Val Thr Leu Glu Leu Gly Pro Gly Gly Pro 
        195                 200                 205             


Arg Ala Arg Thr Gln Arg Leu Leu Arg Gln Leu Asp Ala Pro Val Phe 
    210                 215                 220                 


Val Ala Tyr Cys Ser Arg Glu Glu Ala Glu Val Leu Phe Ala Glu Ala 
225                 230                 235                 240 


Ala Gln Ala Gly Leu Val Gly Pro Gly His Val Trp Leu Val Pro Asn 
                245                 250                 255     


Leu Ala Leu Gly Ser Thr Asp Ala Pro Pro Ala Thr Phe Pro Val Gly 
            260                 265                 270         


Leu Ile Ser Val Val Thr Glu Ser Trp Arg Leu Ser Leu Arg Gln Lys 
        275                 280                 285             


Val Arg Asp Gly Val Ala Ile Leu Ala Leu Gly Ala His Ser Tyr Trp 
    290                 295                 300                 


Arg Gln His Gly Thr Leu Pro Ala Pro Ala Gly Asp Cys Arg Val His 
305                 310                 315                 320 


Pro Gly Pro Val Ser Pro Ala Arg Glu Ala Phe Tyr Arg His Leu Leu 
                325                 330                 335     


Asn Val Thr Trp Glu Gly Arg Asp Phe Ser Phe Ser Pro Gly Gly Tyr 
            340                 345                 350         


Leu Val Gln Pro Thr Met Val Val Ile Ala Leu Asn Arg His Arg Leu 
        355                 360                 365             


Trp Glu Met Val Gly Arg Trp Glu His Gly Val Leu Tyr Met Lys Tyr 
    370                 375                 380                 


Pro Val Trp Pro Arg Tyr Ser Ala Ser Leu Gln Pro Val Val Asp Ser 
385                 390                 395                 400 


Arg His Leu Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile Val 
                405                 410                 415     


Glu Ser Pro Asp Pro Gly Thr Gly Gly Cys Val Pro Asn Thr Val Pro 
            420                 425                 430         


Cys Arg Arg Gln Ser Asn His Thr Phe Ser Ser Gly Asp Val Ala Pro 
        435                 440                 445             


Tyr Thr Lys Leu Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys Lys 
    450                 455                 460                 


Leu Ala Arg Val Val Lys Phe Ser Tyr Asp Leu Tyr Leu Val Thr Asn 
465                 470                 475                 480 


Gly Lys His Gly Lys Arg Val Arg Gly Val Trp Asn Gly Met Ile Gly 
                485                 490                 495     


Glu Val Tyr Tyr Lys Arg Ala Asp Met Ala Ile Gly Ser Leu Thr Ile 
            500                 505                 510         


Asn Glu Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe Val Glu 
        515                 520                 525             


Thr Gly Ile Ser Val Met Val Ala Arg Ser Asn Gly Thr Val Ser Pro 
    530                 535                 540                 


Ser Ala Phe Leu Glu Pro Tyr Ser Pro Ala Val Trp Val Met Met Phe 
545                 550                 555                 560 


Val Met Cys Leu Thr Val Val Ala Ile Thr Val Phe Met Phe Glu Tyr 
                565                 570                 575     


Phe Ser Pro Val Ser Tyr Asn Gln Asn Leu Thr Arg Gly Lys Lys Ser 
            580                 585                 590         


Gly Gly Pro Ala Phe Thr Ile Gly Lys Ser Val Trp Leu Leu Trp Ala 
        595                 600                 605             


Leu Val Phe Asn Asn Ser Val Pro Ile Glu Asn Pro Arg Gly Thr Thr 
    610                 615                 620                 


Ser Lys Ile Met Val Leu Val Trp Ala Phe Phe Ala Val Ile Phe Leu 
625                 630                 635                 640 


Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu Gln Tyr 
                645                 650                 655     


Ile Asp Thr Val Ser Gly Leu Ser Asp Lys Lys Phe Gln Arg Pro Gln 
            660                 665                 670         


Asp Gln Tyr Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly Ser Thr 
        675                 680                 685             


Glu Arg Asn Ile Arg Ser Asn Tyr Arg Asp Met His Thr His Met Val 
    690                 695                 700                 


Lys Phe Asn Gln Arg Ser Val Glu Asp Ala Leu Thr Ser Leu Lys Met 
705                 710                 715                 720 


Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met 
                725                 730                 735     


Ala Gly Lys Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys 
            740                 745                 750         


Val Phe Ala Thr Thr Gly Tyr Gly Ile Ala Met Gln Lys Asp Ser His 
        755                 760                 765             


Trp Lys Arg Ala Ile Asp Leu Ala Leu Leu Gln Phe Leu Gly Asp Gly 
    770                 775                 780                 


Glu Thr Gln Lys Leu Glu Thr Val Trp Leu Ser Gly Ile Cys Gln Asn 
785                 790                 795                 800 


Glu Lys Asn Glu Val Met Ser Ser Lys Leu Asp Ile Asp Asn Met Ala 
                805                 810                 815     


Gly Val Phe Tyr Met Leu Leu Val Ala Met Gly Leu Ala Leu Leu Val 
            820                 825                 830         


Phe Ala Trp Glu His Leu Val Tyr Trp Lys Leu Arg His Ser Val Pro 
        835                 840                 845             


Asn Ser Ser Gln Leu Asp Phe Leu Leu Ala Phe Ser Arg Gly Ile Tyr 
    850                 855                 860                 


Ser Cys Phe Ser Gly Val Gln Ser Leu Ala Ser Pro Pro Arg Gln Ala 
865                 870                 875                 880 


Ser Pro Asp Leu Thr Ala Ser Ser Ala Gln Ala Ser Val Leu Lys Met 
                885                 890                 895     


Leu Gln Ala Ala Arg Asp Met Val Thr Thr Ala Gly Val Ser Ser Ser 
            900                 905                 910         


Leu Asp Arg Ala Thr Arg Thr Ile Glu Asn Trp Gly Gly Gly Arg Arg 
        915                 920                 925             


Ala Pro Pro Pro Ser Pro Cys Pro Thr Pro Arg Ser Gly Pro Ser Pro 
    930                 935                 940                 


Cys Leu Pro Thr Pro Asp Pro Pro Pro Glu Pro Ser Pro Thr Gly Trp 
945                 950                 955                 960 


Gly Pro Pro Asp Gly Gly Arg Ala Ala Leu Val Arg Arg Ala Pro Gln 
                965                 970                 975     


Pro Pro Gly Arg Pro Pro Thr Pro Gly Pro Pro Leu Ser Asp Val Ser 
            980                 985                 990         


Arg Val Ser Arg Arg Pro Ala Trp  Glu Ala Arg Trp Pro  Val Arg Thr 
        995                 1000                 1005             


Gly His  Cys Gly Arg His Leu  Ser Ala Ser Glu Arg  Pro Leu Ser 
    1010                 1015                 1020             


Pro Ala  Arg Cys His Tyr Ser  Ser Phe Pro Arg Ala  Asp Arg Ser 
    1025                 1030                 1035             


Gly Arg  Pro Phe Leu Pro Leu  Phe Pro Glu Leu Glu  Asp Leu Pro 
    1040                 1045                 1050             


Leu Leu  Gly Pro Glu Gln Leu  Ala Arg Arg Glu Ala  Leu Leu His 
    1055                 1060                 1065             


Ala Ala  Trp Ala Arg Gly Ser  Arg Pro Arg His Ala  Ser Leu Pro 
    1070                 1075                 1080             


Ser Ser  Val Ala Glu Ala Phe  Ala Arg Pro Ser Ser  Leu Pro Ala 
    1085                 1090                 1095             


Gly Cys  Thr Gly Pro Ala Cys  Ala Arg Pro Asp Gly  His Ser Ala 
    1100                 1105                 1110             


Cys Arg  Arg Leu Ala Gln Ala  Gln Ser Met Cys Leu  Pro Ile Tyr 
    1115                 1120                 1125             


Arg Glu  Ala Cys Gln Glu Gly  Glu Gln Ala Gly Ala  Pro Ala Trp 
    1130                 1135                 1140             


Gln His  Arg Gln His Val Cys  Leu His Ala His Ala  His Leu Pro 
    1145                 1150                 1155             


Phe Cys  Trp Gly Ala Val Cys  Pro His Leu Pro Pro  Cys Ala Ser 
    1160                 1165                 1170             


His Gly  Ser Trp Leu Ser Gly  Ala Trp Gly Pro Leu  Gly His Arg 
    1175                 1180                 1185             


Gly Arg  Thr Leu Gly Leu Gly  Thr Gly Tyr Arg Asp  Ser Gly Gly 
    1190                 1195                 1200             


Leu Asp  Glu Ile Ser Arg Val  Ala Arg Gly Thr Gln  Gly Phe Pro 
    1205                 1210                 1215             


Gly Pro  Cys Thr Trp Arg Arg  Ile Ser Ser Leu Glu  Ser Glu Val 
    1220                 1225                 1230             


<210>  3592
<211>  1838
<212>  DNA
<213>  Homosapiens

<400>  3592
atccacttgc aggttgctgc tcccagccat ggcttcgcgc tgctggcgct ggtggggctg     60

gtcggcgtgg cctcggaccc ggctgcctcc cgccgggagc accccgagct tctgccacca    120

tttctccaca caggagaaga ccccccagat ctgtgtggtg ggcagtggcc cagctggctt    180

ctacacggcc caacacctgc taaagcaccc ccaggcccac gtggacatct acgagaaaca    240

gcctgtgccc tttggcctgg tgcgctttgg tgtggcgcct gatcaccccg aggtgaagaa    300

tgtcatcaac acatttaccc agacggccca ttctggccgc tgtgccttct ggggcaacgt    360

ggaggtgggc agggacgtga cggtgccgga gctgcaggag gcctaccacg ctgtggtgct    420

gagctacggg gcagaggacc atcgggccct ggaaattcct ggtgaggagc tgccaggtgt    480

gtgctccgcc cgggccttcg tgggctggta caacgggctt cctgagaacc aggagctgga    540

gccagacctg agctgtgaca cagccgtgat tctggggcag gggaacgtgg ctctggacgt    600

ggcccgcatc ctactgaccc cacctgagca cctggaggcc ctccttttgt gccagagaac    660

ggacatcacg aaggcagccc tgggtgtact gaggcagagt cgagtgaaga cagtgtggct    720

agtgggccgg cgtggacccc tgcaagtggc cttcaccatt aaggagcttc gggagatgat    780

tcagttaccg ggagcccggc ccattttgga tcctgtggat ttcttgggtc tccaggacaa    840

gatcaaggag gtcccccgcc cgaggaagcg gctgacggaa ctgctgcttc gaacggccac    900

agagaagcca gggccggcgg aagctgcccg ccaggcatcg gcctcccgtg cctggggcct    960

ccgctttttc cgaagccccc agcaggtgct gccctcacca gatgggcggc gggcagcagg   1020

tgtccgccta gcagtcacta gactggaggg tgtcgatgag gccacccgtg cagtgcccac   1080

gggagacatg gaagacctcc cttgtgggct ggtgctcagc agcattgggt ataagagccg   1140

ccctgtcgac ccaagcgtgc cctttgactc caagcttggg gtcatcccca atgtggaggg   1200

ccgggttatg gatgtgccag gcctctactg cagcggctgg gtgaagagag gacctacagg   1260

tgtcatagcc acaaccatga ctgacagctt cctcaccggc cagatgctgc tgcaggacct   1320

gaaggctggg ttgctcccct ctggccccag gcctggctac gcagccatcc aggccctgct   1380

cagcagccga ggggtccggc cagtctcttt ctcagactgg gagaagctgg atgccgagga   1440

ggtggcccgg ggccagggca cggggaagcc cagggagaag ctggtggatc ctcaggagat   1500

gctgcgcctc ctgggccact gagcccagcc ccagccccgg cccccagcag ggaagggatg   1560

agtgttggga ggggaagggc tgggtccgtc tgagtgggac tttgcacctc tgctgatccc   1620

ggccggccct ggcttggagg cttggctgct cttccagcgt ctctcctccc tcctggggaa   1680

ggtcgccctt gcgcgcaagg ttttagcttt cagcaactga ggtaacctta gggacaggtg   1740

gaggtgtggg ccgatctaac cccttaccca tctctctact gctggactgt ggagggtcac   1800

caggttggga acatgctgga aataaaacag ctgcaccc                           1838


<210>  3593
<211>  497
<212>  PRT
<213>  Homosapiens

<400>  3593

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
            20                  25                  30          


Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro 
        35                  40                  45              


Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His 
    50                  55                  60                  


Val Asp Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe 
65                  70                  75                  80  


Gly Val Ala Pro Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe 
                85                  90                  95      


Thr Gln Thr Ala His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu 
            100                 105                 110         


Val Gly Arg Asp Val Thr Val Pro Glu Leu Gln Glu Ala Tyr His Ala 
        115                 120                 125             


Val Val Leu Ser Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro 
    130                 135                 140                 


Gly Glu Glu Leu Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp 
145                 150                 155                 160 


Tyr Asn Gly Leu Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys 
                165                 170                 175     


Asp Thr Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala 
            180                 185                 190         


Arg Ile Leu Leu Thr Pro Pro Glu His Leu Glu Ala Leu Leu Leu Cys 
        195                 200                 205             


Gln Arg Thr Asp Ile Thr Lys Ala Ala Leu Gly Val Leu Arg Gln Ser 
    210                 215                 220                 


Arg Val Lys Thr Val Trp Leu Val Gly Arg Arg Gly Pro Leu Gln Val 
225                 230                 235                 240 


Ala Phe Thr Ile Lys Glu Leu Arg Glu Met Ile Gln Leu Pro Gly Ala 
                245                 250                 255     


Arg Pro Ile Leu Asp Pro Val Asp Phe Leu Gly Leu Gln Asp Lys Ile 
            260                 265                 270         


Lys Glu Val Pro Arg Pro Arg Lys Arg Leu Thr Glu Leu Leu Leu Arg 
        275                 280                 285             


Thr Ala Thr Glu Lys Pro Gly Pro Ala Glu Ala Ala Arg Gln Ala Ser 
    290                 295                 300                 


Ala Ser Arg Ala Trp Gly Leu Arg Phe Phe Arg Ser Pro Gln Gln Val 
305                 310                 315                 320 


Leu Pro Ser Pro Asp Gly Arg Arg Ala Ala Gly Val Arg Leu Ala Val 
                325                 330                 335     


Thr Arg Leu Glu Gly Val Asp Glu Ala Thr Arg Ala Val Pro Thr Gly 
            340                 345                 350         


Asp Met Glu Asp Leu Pro Cys Gly Leu Val Leu Ser Ser Ile Gly Tyr 
        355                 360                 365             


Lys Ser Arg Pro Val Asp Pro Ser Val Pro Phe Asp Ser Lys Leu Gly 
    370                 375                 380                 


Val Ile Pro Asn Val Glu Gly Arg Val Met Asp Val Pro Gly Leu Tyr 
385                 390                 395                 400 


Cys Ser Gly Trp Val Lys Arg Gly Pro Thr Gly Val Ile Ala Thr Thr 
                405                 410                 415     


Met Thr Asp Ser Phe Leu Thr Gly Gln Met Leu Leu Gln Asp Leu Lys 
            420                 425                 430         


Ala Gly Leu Leu Pro Ser Gly Pro Arg Pro Gly Tyr Ala Ala Ile Gln 
        435                 440                 445             


Ala Leu Leu Ser Ser Arg Gly Val Arg Pro Val Ser Phe Ser Asp Trp 
    450                 455                 460                 


Glu Lys Leu Asp Ala Glu Glu Val Ala Arg Gly Gln Gly Thr Gly Lys 
465                 470                 475                 480 


Pro Arg Glu Lys Leu Val Asp Pro Gln Glu Met Leu Arg Leu Leu Gly 
                485                 490                 495     


His 
    


<210>  3594
<211>  1817
<212>  DNA
<213>  Homosapiens

<400>  3594
atccacttgc aggttgctgc tcccagccat ggcttcgcgc tgctggcgct ggtggggctg     60

gtcggcgtgg cctcggaccc ggctgcctcc cgccgggagc accccgagct tctgccacca    120

tttctccaca caggagaaga ccccccagat ctgtgtggtg ggcagtggcc cagctggctt    180

ctacacggcc caacacctgc taaagcaccc ccaggcccac gtggacatct acgagaaaca    240

gcctgtgccc tttggcctgg tgcgctttgg tgtggcgcct gatcaccccg aggtgaagaa    300

tgtcatcaac acatttaccc agacggccca ttctggccgc tgtgccttct ggggcaacgt    360

ggaggtgggc agggacgtga cggtgccgga gctgcaggag gcctaccacg ctgtggtgct    420

gagctacggg gcagaggacc atcgggccct ggaaattcct ggtgaggagc tgccaggtgt    480

gtgctccgcc cgggccttcg tgggctggta caacgggctt cctgagaacc aggagctgga    540

gccagacctg agctgtgaca cagccgtgat tctggggcag gggaacgtgg ctctggacgt    600

ggcccgcatc ctactgaccc cacctgagca cctggagaga acggacatca cgaaggcagc    660

cctgggtgta ctgaggcaga gtcgagtgaa gacagtgtgg ctagtgggcc ggcgtggacc    720

cctgcaagtg gccttcacca ttaaggagct tcgggagatg attcagttac cgggagcccg    780

gcccattttg gatcctgtgg atttcttggg tctccaggac aagatcaagg aggtcccccg    840

cccgaggaag cggctgacgg aactgctgct tcgaacggcc acagagaagc cagggccggc    900

ggaagctgcc cgccaggcat cggcctcccg tgcctggggc ctccgctttt tccgaagccc    960

ccagcaggtg ctgccctcac cagatgggcg gcgggcagca ggtgtccgcc tagcagtcac   1020

tagactggag ggtgtcgatg aggccacccg tgcagtgccc acgggagaca tggaagacct   1080

cccttgtggg ctggtgctca gcagcattgg gtataagagc cgccctgtcg acccaagcgt   1140

gccctttgac tccaagcttg gggtcatccc caatgtggag ggccgggtta tggatgtgcc   1200

aggcctctac tgcagcggct gggtgaagag aggacctaca ggtgtcatag ccacaaccat   1260

gactgacagc ttcctcaccg gccagatgct gctgcaggac ctgaaggctg ggttgctccc   1320

ctctggcccc aggcctggct acgcagccat ccaggccctg ctcagcagcc gaggggtccg   1380

gccagtctct ttctcagact gggagaagct ggatgccgag gaggtggccc ggggccaggg   1440

cacggggaag cccagggaga agctggtgga tcctcaggag atgctgcgcc tcctgggcca   1500

ctgagcccag ccccagcccc ggcccccagc agggaaggga tgagtgttgg gaggggaagg   1560

gctgggtccg tctgagtggg actttgcacc tctgctgatc ccggccggcc ctggcttgga   1620

ggcttggctg ctcttccagc gtctctcctc cctcctgggg aaggtcgccc ttgcgcgcaa   1680

ggttttagct ttcagcaact gaggtaacct tagggacagg tggaggtgtg ggccgatcta   1740

accccttacc catctctcta ctgctggact gtggagggtc accaggttgg gaacatgctg   1800

gaaataaaac agctgca                                                  1817


<210>  3595
<211>  491
<212>  PRT
<213>  Homosapiens

<400>  3595

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
            20                  25                  30          


Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro 
        35                  40                  45              


Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His 
    50                  55                  60                  


Val Asp Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe 
65                  70                  75                  80  


Gly Val Ala Pro Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe 
                85                  90                  95      


Thr Gln Thr Ala His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu 
            100                 105                 110         


Val Gly Arg Asp Val Thr Val Pro Glu Leu Gln Glu Ala Tyr His Ala 
        115                 120                 125             


Val Val Leu Ser Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro 
    130                 135                 140                 


Gly Glu Glu Leu Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp 
145                 150                 155                 160 


Tyr Asn Gly Leu Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys 
                165                 170                 175     


Asp Thr Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala 
            180                 185                 190         


Arg Ile Leu Leu Thr Pro Pro Glu His Leu Glu Arg Thr Asp Ile Thr 
        195                 200                 205             


Lys Ala Ala Leu Gly Val Leu Arg Gln Ser Arg Val Lys Thr Val Trp 
    210                 215                 220                 


Leu Val Gly Arg Arg Gly Pro Leu Gln Val Ala Phe Thr Ile Lys Glu 
225                 230                 235                 240 


Leu Arg Glu Met Ile Gln Leu Pro Gly Ala Arg Pro Ile Leu Asp Pro 
                245                 250                 255     


Val Asp Phe Leu Gly Leu Gln Asp Lys Ile Lys Glu Val Pro Arg Pro 
            260                 265                 270         


Arg Lys Arg Leu Thr Glu Leu Leu Leu Arg Thr Ala Thr Glu Lys Pro 
        275                 280                 285             


Gly Pro Ala Glu Ala Ala Arg Gln Ala Ser Ala Ser Arg Ala Trp Gly 
    290                 295                 300                 


Leu Arg Phe Phe Arg Ser Pro Gln Gln Val Leu Pro Ser Pro Asp Gly 
305                 310                 315                 320 


Arg Arg Ala Ala Gly Val Arg Leu Ala Val Thr Arg Leu Glu Gly Val 
                325                 330                 335     


Asp Glu Ala Thr Arg Ala Val Pro Thr Gly Asp Met Glu Asp Leu Pro 
            340                 345                 350         


Cys Gly Leu Val Leu Ser Ser Ile Gly Tyr Lys Ser Arg Pro Val Asp 
        355                 360                 365             


Pro Ser Val Pro Phe Asp Ser Lys Leu Gly Val Ile Pro Asn Val Glu 
    370                 375                 380                 


Gly Arg Val Met Asp Val Pro Gly Leu Tyr Cys Ser Gly Trp Val Lys 
385                 390                 395                 400 


Arg Gly Pro Thr Gly Val Ile Ala Thr Thr Met Thr Asp Ser Phe Leu 
                405                 410                 415     


Thr Gly Gln Met Leu Leu Gln Asp Leu Lys Ala Gly Leu Leu Pro Ser 
            420                 425                 430         


Gly Pro Arg Pro Gly Tyr Ala Ala Ile Gln Ala Leu Leu Ser Ser Arg 
        435                 440                 445             


Gly Val Arg Pro Val Ser Phe Ser Asp Trp Glu Lys Leu Asp Ala Glu 
    450                 455                 460                 


Glu Val Ala Arg Gly Gln Gly Thr Gly Lys Pro Arg Glu Lys Leu Val 
465                 470                 475                 480 


Asp Pro Gln Glu Met Leu Arg Leu Leu Gly His 
                485                 490     


<210>  3596
<211>  4685
<212>  DNA
<213>  Homosapiens

<400>  3596
gggagcgcgg ggagcgcggg ccggcggcgg cgagggagga cgggggcgca gacggccggc     60

gcgcggcgcg gctaccatgg gcgtgcggtg agcagccgct cgggacgact tcctcggctg    120

cgcggcgctc gcgcggagct ccccggccgg cggtgcgtcc ccacggtcac catgaaagac    180

gacttcgcag aggaggagga ggtgcaatcc ttcggttaca agcggtttgg tattcaggaa    240

ggaacacaat gtaccaaatg taaaaataac tgggcactga agttttctat catattatta    300

tacattttgt gtgccttgct aacaatcaca gtagccattt tgggatataa agttgtagag    360

aaaatggaca atgtcacagg tggcatggaa acatctcgcc aaacctatga tgacaagctc    420

acagcagtgg aaagtgacct gaaaaaatta ggtgaccaaa ctgggaagaa agctatcagc    480

accaactcag aactctccac cttcagatca gacattctag atctccgtca gcaacttcgt    540

gagattacag aaaaaaccag caagaacaag gatacgctgg agaagttaca ggcgagcggg    600

gatgctctgg tggacaggca gagtcaattg aaagaaactt tggagaataa ctctttcctc    660

atcaccactg taaacaaaac cctccaggcg tataatggct atgtcacgaa tctgcagcaa    720

gataccagcg tgctccaggg caatctgcag aaccaaatgt attctcataa tgtggtcatc    780

atgaacctca acaacctgaa cctgacccag gtgcagcaga ggaacctcat cacgaatctg    840

cagcggtctg tggatgacac aagccaggct atccagcgaa tcaagaacga ctttcaaaat    900

ctgcagcagg tttttcttca agccaagaag gacacggatt ggctgaagga gaaagtgcag    960

agcttgcaga cactggctgc caacaactct gcgttggcca aagccaacaa cgacaccctg   1020

gaggatatga acagccagct caactcattc acaggtcaga tggagaacat caccactatc   1080

tctcaagcca acgagcagaa cctgaaagac ctgcaggact tacacaaaga tgcagagaat   1140

agaacagcca tcaagttcaa ccaactggag gaacgcttcc agctctttga gacggatatt   1200

gtgaacatca ttagcaatat cagttacaca gcccaccacc tgcggacgct gaccagcaat   1260

ctaaatgaag tcaggaccac ttgcacagat acccttacca aacacacaga tgatctgacc   1320

tccttgaata ataccctggc caacatccgt ttggattctg tttctctcag gatgcaacaa   1380

gatttgatga ggtcgaggtt agacactgaa gtagccaact tatcagtgat tatggaagaa   1440

atgaagctag tagactccaa gcatggtcag ctcatcaaga attttacaat actacaaggt   1500

ccaccgggcc ccaggggtcc aagaggtgac agaggatccc agggaccccc tggcccaact   1560

ggcaacaagg gacagaaagg agagaagggg gagcctggac cacctggccc tgcgggtgag   1620

agaggcccaa ttggaccagc tggtcccccc ggagagcgtg gcggcaaagg atctaaaggc   1680

tcccagggcc ccaaaggctc ccgtggttcc cctgggaagc ccggccctca gggccccagt   1740

ggggacccag gccccccggg cccaccaggc aaagagggac tccccggccc tcagggccct   1800

cctggcttcc agggacttca gggcaccgtt ggggagcctg gggtgcctgg acctcgggga   1860

ctgccaggct tgcctggggt accaggcatg ccaggcccca agggcccccc cggccctcct   1920

ggcccatcag gagcggtggt gcccctggcc ctgcagaatg agccaacccc ggcaccggag   1980

gacaatagta agtccaagcc ctccctccag ccagggggac agggcagtgc atgtgcttga   2040

gactgagcca acccccagtg tgtggcccca cccatgttat ttttgttttt gtttttgttt   2100

tgagacaggg tctcactctg ttgcccaggc tggagtgcag tggcgtgatc tcggctcact   2160

gcaaccccca catcccgggt tcaagtgatt ctcctgcctt agcctcccag gtagctggga   2220

atacaagcgt gtgcccccac agccagctaa tttttgtatt tttagtagag aggggtttca   2280

cagtgttggg cagggtggtt tcaaacttct ggcctcaagt gatccaccta cctagtttcc   2340

caaagtgctg ggaatacagg tgtgaaccac cacgttttgt cccccggctg catattattt   2400

aacagcaaag gcatcatagg ggttggcaca ggagccctgc tgccagaaca ggcctccata   2460

ccaggcatgt gtctctctct aaacgccatt gggtttttta gtgctcattt gttttatgta   2520

ttatgtgtgt atgtatggga cagggtctca ctctgtcacc caggctggaa tgacgaagtg   2580

aagtagtgca aacatagctc attgcagctt tgacctcctg ggcttaggtg atcttcccac   2640

tcagactcct gcgtagctgg gaccacaggg gtatgccacc acacctggct aattttttat   2700

tttccttttt gtagaaacag ggtcttgcta tgttgcccag gctggtcttg aactcctggc   2760

ctcaagcaac cctcctgcct cagtcttgca aagtgctggg attccaggtg ggagccactg   2820

cacctggctc ttgcacttgt ttatttatag gagccagccc tcagaagaca aacacaatgc   2880

aaaacatttc cttcagggaa gcctgctggc cgccctgagc gctcttccct cgttttacat   2940

cctcactctg gagatagatg ggctccctcg gttagctcca tcaacatgtg gatggaaccc   3000

tctgctattg atgactacat ttaatttctt tttgagaaag gtgttagatg ttacggtgcc   3060

ttctagtctt ttgataatta aacctttggc aaaactcgaa tgtttggtta gcaaccaagc   3120

ctatttttct ctcctttgac ccaaccgcta ttctacttga ttttggtcgg tgaggcccgg   3180

gttatttttg ttgatccgtg agcccatttt tggtgctggg ttctcacatc caagtgttcc   3240

tgggttccgt atgattccag actgacgctg aacatctgtg cctgccctgc ttcttgttgt   3300

tgcttctgtc atttctgtca ttgtgaagac ggatccaaac acagaagaac aaagacccag   3360

tccaagatcc atccagatta tgtggtttcg gcttgtgctc tgcagtccac tttgggtcat   3420

gcttgctgcg agcacgtccg tgaacgtcag ctgtgggcct cgtgcaggga cgctcaggct   3480

gctcccagcg ggaccacagt tttggcctct gaaacacagc tgaagaaagg cagagtgctt   3540

tctgtgatct tttaatcaat gttttccact tttgcattcc taggctgccc gcctcactgg   3600

aagaacttca cagacaaatg ctactatttt tcagttgaga aagaaatttt tgaggatgca   3660

aagcttttct gtgaagacaa gtcttcacat cttgttttca taaacactag agaggaacag   3720

caatggataa aaaaacagat ggtagggaga gagagccact ggatcggcct cacagactca   3780

gagcgtgaaa atgaatggaa gtggctggat gggacatctc cagactacaa aaattggaaa   3840

gctggacagc cggataactg gggtcatggc catgggccag gagaagactg tgctgggttg   3900

atttatgctg ggcagtggaa cgatttccaa tgtgaagacg tcaataactt catttgcgaa   3960

aaagacaggg agacagtact gtcatctgca ttataacgga ctgtgatggg atcacatgag   4020

caaattttca gctctcaaag gcaaaggaca ctcctttcta attgcatcac cttctcatca   4080

gattgaaaaa aaaaaagcac tgaaaaccaa ttactgaaaa aaaattgaca gctagtgttt   4140

tttaccatcc gtcattaccc aaagacttgg gaactaaaat gttccccagg gtgatatgct   4200

gattttcatt gtgcacatgg actgaatcac atagattctc ctccgtcagt aaccgtgcga   4260

ttatacaaat tatgtcttcc aaagtatgga acactccaat cagaaaaagg ttatcattgg   4320

tcgttgagtt atgggaagaa cttaagcata tactgtgtaa acagtgccat acatttctaa   4380

aatcccaagt gtaggaaaaa tatgcagaca tacagatata taggccaact attagtaata   4440

atatgaaata tacttaaaga gcttttaaaa ctttgtattt ttgtacaaaa tatttgtctt   4500

ttacaatttt tttccttttt ttttttttgt cattttaccg acataataca tggagccaaa   4560

gaaaacaata atggtactaa taaaaactcc tagggtttcc tgtcagattt aattctaccc   4620

agtggcaaag aattttttca attgtggctt taaaaaaata attaaatata catgtatata   4680

tatat                                                               4685


<210>  3597
<211>  622
<212>  PRT
<213>  Homosapiens

<400>  3597

Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Pro Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Ser Lys Ser 
        595                 600                 605             


Lys Pro Ser Leu Gln Pro Gly Gly Gln Gly Ser Ala Cys Ala 
    610                 615                 620         


<210>  3598
<211>  3089
<212>  DNA
<213>  Homosapiens

<400>  3598
gggagcgcgg ggagcgcggg ccggcggcgg cgagggagga cgggggcgca gacggccggc     60

gcgcggcgcg gctaccatgg gcgtgcggtg agcagccgct cgggacgact tcctcggctg    120

cgcggcgctc gcgcggagct ccccggccgg cggtgcgtcc ccacggtcac catgaaagac    180

gacttcgcag aggaggagga ggtgcaatcc ttcggttaca agcggtttgg tattcaggaa    240

ggaacacaat gtaccaaatg taaaaataac tgggcactga agttttctat catattatta    300

tacattttgt gtgccttgct aacaatcaca gtagccattt tgggatataa agttgtagag    360

aaaatggaca atgtcacagg tggcatggaa acatctcgcc aaacctatga tgacaagctc    420

acagcagtgg aaagtgacct gaaaaaatta ggtgaccaaa ctgggaagaa agctatcagc    480

accaactcag aactctccac cttcagatca gacattctag atctccgtca gcaacttcgt    540

gagattacag aaaaaaccag caagaacaag gatacgctgg agaagttaca ggcgagcggg    600

gatgctctgg tggacaggca gagtcaattg aaagaaactt tggagaataa ctctttcctc    660

atcaccactg taaacaaaac cctccaggcg tataatggct atgtcacgaa tctgcagcaa    720

gataccagcg tgctccaggg caatctgcag aaccaaatgt attctcataa tgtggtcatc    780

atgaacctca acaacctgaa cctgacccag gtgcagcaga ggaacctcat cacgaatctg    840

cagcggtctg tggatgacac aagccaggct atccagcgaa tcaagaacga ctttcaaaat    900

ctgcagcagg tttttcttca agccaagaag gacacggatt ggctgaagga gaaagtgcag    960

agcttgcaga cactggctgc caacaactct gcgttggcca aagccaacaa cgacaccctg   1020

gaggatatga acagccagct caactcattc acaggtcaga tggagaacat caccactatc   1080

tctcaagcca acgagcagaa cctgaaagac ctgcaggact tacacaaaga tgcagagaat   1140

agaacagcca tcaagttcaa ccaactggag gaacgcttcc agctctttga gacggatatt   1200

gtgaacatca ttagcaatat cagttacaca gcccaccacc tgcggacgct gaccagcaat   1260

ctaaatgaag tcaggaccac ttgcacagat acccttacca aacacacaga tgatctgacc   1320

tccttgaata ataccctggc caacatccgt ttggattctg tttctctcag gatgcaacaa   1380

gatttgatga ggtcgaggtt agacactgaa gtagccaact tatcagtgat tatggaagaa   1440

atgaagctag tagactccaa gcatggtcag ctcatcaaga attttacaat actacaaggt   1500

ccaccgggcc ccaggggtcc aagaggtgac agaggatccc agggaccccc tggcccaact   1560

ggcaacaagg gacagaaagg agagaagggg gagcctggac cacctggccc tgcgggtgag   1620

agaggcccaa ttggaccagc tggtcccccc ggagagcgtg gcggcaaagg atctaaaggc   1680

tcccagggcc ccaaaggctc ccgtggttcc cctgggaagc ccggccctca gggccccagt   1740

ggggacccag gccccccggg cccaccaggc aaagagggac tccccggccc tcagggccct   1800

cctggcttcc agggacttca gggcaccgtt ggggagcctg gggtgcctgg acctcgggga   1860

ctgccaggct tgcctggggt accaggcatg ccaggcccca agggcccccc cggccctcct   1920

ggcccatcag gagcggtggt gcccctggcc ctgcagaatg agccaacccc ggcaccggag   1980

gacaatggct gcccgcctca ctggaagaac ttcacagaca aatgctacta tttttcagtt   2040

gagaaagaaa tttttgagga tgcaaagctt ttctgtgaag acaagtcttc acatcttgtt   2100

ttcataaaca ctagagagga acagcaatgg ataaaaaaac agatggtagg gagagagagc   2160

cactggatcg gcctcacaga ctcagagcgt gaaaatgaat ggaagtggct ggatgggaca   2220

tctccagact acaaaaattg gaaagctgga cagccggata actggggtca tggccatggg   2280

ccaggagaag actgtgctgg gttgatttat gctgggcagt ggaacgattt ccaatgtgaa   2340

gacgtcaata acttcatttg cgaaaaagac agggagacag tactgtcatc tgcattataa   2400

cggactgtga tgggatcaca tgagcaaatt ttcagctctc aaaggcaaag gacactcctt   2460

tctaattgca tcaccttctc atcagattga aaaaaaaaaa gcactgaaaa ccaattactg   2520

aaaaaaaatt gacagctagt gttttttacc atccgtcatt acccaaagac ttgggaacta   2580

aaatgttccc cagggtgata tgctgatttt cattgtgcac atggactgaa tcacatagat   2640

tctcctccgt cagtaaccgt gcgattatac aaattatgtc ttccaaagta tggaacactc   2700

caatcagaaa aaggttatca ttggtcgttg agttatggga agaacttaag catatactgt   2760

gtaaacagtg ccatacattt ctaaaatccc aagtgtagga aaaatatgca gacatacaga   2820

tatataggcc aactattagt aataatatga aatatactta aagagctttt aaaactttgt   2880

atttttgtac aaaatatttg tcttttacaa tttttttcct tttttttttt ttgtcatttt   2940

accgacataa tacatggagc caaagaaaac aataatggta ctaataaaaa ctcctagggt   3000

ttcctgtcag atttaattct acccagtggc aaagaatttt ttcaattgtg gctttaaaaa   3060

aataattaaa tatacatgta tatatatat                                     3089


<210>  3599
<211>  742
<212>  PRT
<213>  Homosapiens

<400>  3599

Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Pro Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         


<210>  3600
<211>  3494
<212>  DNA
<213>  Homosapiens

<400>  3600
ggcacccttc ggcgagcgct gtttgtttag ggctcggtga gtccaatcag gagcccaggc     60

tgcagttttc cggcagagca gtaagaggcg cctcctctct cctttttatt caccagcagc    120

gcggcgcaga ccccggactc gcgctcgccc gctggcgccc tcggcttctc tccgcgcctg    180

ggagcaccct ccgccgcggc cgttctccat gcgcagcgcc cgcccgagga gctagacgtc    240

agcttggagc ggcgccggac cgtggatggc cttgactgac ggcggctggt gcttgccgaa    300

gcgcttcggg gccgcgggtg cggacgccag cgactccaga gcctttccag cgcgggagcc    360

ctccacgccg ccttccccca tctcttcctc gtcctcctcc tgctcccggg gcggagagcg    420

gggccccggc ggcgccagca actgcgggac gcctcagctc gacacggagg cggcggccgg    480

acccccggcc cgctcgctgc tgctcagttc ctacgcttcg catcccttcg gggctcccca    540

cggaccttcg gcgcctgggg tcgcgggccc cgggggcaac ctgtcgagct gggaggactt    600

gctgctgttc actgacctcg accaagccgc gaccgccagc aagctgctgt ggtccagccg    660

cggcgccaag ctgagcccct tcgcacccga gcagccggag gagatgtacc agaccctcgc    720

cgctctctcc agccagggtc cggccgccta cgacggcgcg cccggcggct tcgtgcactc    780

tgcggccgcg gcggcagcag ccgcggcggc ggccagctcc ccggtctacg tgcccaccac    840

ccgcgtgggt tccatgctgc ccggcctacc gtaccacctg caggggtcgg gcagtgggcc    900

agccaaccac gcgggcggcg cgggcgcgca ccccggctgg cctcaggcct cggccgacag    960

ccctccatac ggcagcggag gcggcgcggc tggcggcggg gccgcggggc ctggcggcgc   1020

tggctcagcc gcggcgcacg tctcggcgcg cttcccctac tctcccagcc cgcccatggc   1080

caacggcgcc gcgcgggagc cgggaggcta cgcggcggcg ggcagtgggg gcgcgggagg   1140

cgtgagcggc ggcggcagta gcctggcggc catgggcggc cgcgagcccc agtacagctc   1200

gctgtcggcc gcgcggccgc tgaacgggac gtaccaccac caccaccacc accaccacca   1260

ccatccgagc ccctactcgc cctacgtggg ggcgccactg acgcctgcct ggcccgccgg   1320

acccttcgag accccggtgc tgcacagcct gcagagccgc gccggagccc cgctcccggt   1380

gccccggggt cccagtgcag acctgctgga ggacctgtcc gagagccgcg agtgcgtgaa   1440

ctgcggctcc atccagacgc cgctgtggcg gcgggacggc accggccact acctgtgcaa   1500

cgcctgcggg ctctacagca agatgaacgg cctcagccgg cccctcatca agccgcagaa   1560

gcgcgtgcct tcatcacggc ggcttggatt gtcctgtgcc aactgtcaca ccacaactac   1620

caccttatgg cgcagaaacg ccgagggtga acccgtgtgc aatgcttgtg gactctacat   1680

gaaactccat ggggtgccca gaccacttgc tatgaaaaaa gagggaattc aaaccaggaa   1740

acgaaaacct aagaacataa ataaatcaaa gacttgctct ggtaatagca ataattccat   1800

tcccatgact ccaacttcca cctcttctaa ctcagatgat tgcagcaaaa atacttcccc   1860

cacaacacaa cctacagcct caggggcggg tgccccggtg atgactggtg cgggagagag   1920

caccaatccc gagaacagcg agctcaagta ttcgggtcaa gatgggctct acataggcgt   1980

cagtctcgcc tcgccggccg aagtcacgtc ctccgtgcga ccggattcct ggtgcgccct   2040

ggccctggcc tgagcccacg ccgccaggag gcagggaggg ctccgccgcg ggcctcactc   2100

cactcgtgtc tgcttttgtg cagcggtcca gacagtggcg actgcgctga cagaacgtga   2160

ttctcgtgcc tttattttga aagagatgtt tttcccaaga ggcttgctga aagagtgaga   2220

gaagatggaa gggaagggcc agtgcaactg ggcgcttggg ccactccagc cagcccgcct   2280

ccggggcgga ccctgctcca cttccagaag ccaggactag gacctgggcc ttgcctgcta   2340

tggaatattg agagagattt tttaaaaaag attttgcatt ttgtccaaaa tcatgtgctt   2400

cttctgatca attttggttg ttccagaatt tcttcatacc ttttccacat ccagatttca   2460

tgtgcgttca tggagaagat cacttgaggc catttggtac acatctctgg aggctgagtc   2520

ggttcatgag gtctcttatc aaaaatatta ctcagtttgc aagactgcat tgtaacttta   2580

acatacactg tgactgacgt ttctcaaagt tcatattgtg tggctgatct gaagtcagtc   2640

ggaatttgta aacagggtag caaacaagat atttttcttc catgtataca ataatttttt   2700

taaaaagtgc aatttgcgtt gcagcaatca gtgttaaatc atttgcataa gatttaacag   2760

cattttttat aatgaatgta aacattttaa cttaatggta cttaaaataa tttaaaagaa   2820

aaatgttaac ttagacattc ttatgcttct tttacaacta catcccattt tatatttcca   2880

attgttaaag aaaaatattt caagaacaaa tcttctctca ggaaaattgc ctttctctat   2940

ttgttaagaa tttttataca agaacaccaa tataccccct ttattttact gtggaatatg   3000

tgctggaaaa attgcaacaa cactttacta cctaacggat agcatttgta aatactctag   3060

gtatctgtaa acactctgat gaagtctgta tagtgtgact aacccacagg caggttggtt   3120

tacattaatt tttttttttg aatgggatgt cctatggaaa cctatttcac cagagtttta   3180

aaaataaaaa gggtattgtt ttgtcttctg tacagtgagt tccttccctt ttcaaagctt   3240

tctttttatg ctgtatgtga ctatagatat tcatataaaa caagtgcacg tgaagtttgc   3300

aaaatgcttt aaggccttcc tttcaaagca tagtcctttt ggagccgttt tgtacctttt   3360

ataccttggc ttatttgaag ttgacacatg gggttagtta ctactctcca tgtgcattgg   3420

ggacagtttt tataagtggg aaggactcag tattattata tttgagatga taagcatttt   3480

gtttgggaac aatg                                                     3494


<210>  3601
<211>  595
<212>  PRT
<213>  Homosapiens

<400>  3601

Met Ala Leu Thr Asp Gly Gly Trp Cys Leu Pro Lys Arg Phe Gly Ala 
1               5                   10                  15      


Ala Gly Ala Asp Ala Ser Asp Ser Arg Ala Phe Pro Ala Arg Glu Pro 
            20                  25                  30          


Ser Thr Pro Pro Ser Pro Ile Ser Ser Ser Ser Ser Ser Cys Ser Arg 
        35                  40                  45              


Gly Gly Glu Arg Gly Pro Gly Gly Ala Ser Asn Cys Gly Thr Pro Gln 
    50                  55                  60                  


Leu Asp Thr Glu Ala Ala Ala Gly Pro Pro Ala Arg Ser Leu Leu Leu 
65                  70                  75                  80  


Ser Ser Tyr Ala Ser His Pro Phe Gly Ala Pro His Gly Pro Ser Ala 
                85                  90                  95      


Pro Gly Val Ala Gly Pro Gly Gly Asn Leu Ser Ser Trp Glu Asp Leu 
            100                 105                 110         


Leu Leu Phe Thr Asp Leu Asp Gln Ala Ala Thr Ala Ser Lys Leu Leu 
        115                 120                 125             


Trp Ser Ser Arg Gly Ala Lys Leu Ser Pro Phe Ala Pro Glu Gln Pro 
    130                 135                 140                 


Glu Glu Met Tyr Gln Thr Leu Ala Ala Leu Ser Ser Gln Gly Pro Ala 
145                 150                 155                 160 


Ala Tyr Asp Gly Ala Pro Gly Gly Phe Val His Ser Ala Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Val Tyr Val Pro Thr Thr 
            180                 185                 190         


Arg Val Gly Ser Met Leu Pro Gly Leu Pro Tyr His Leu Gln Gly Ser 
        195                 200                 205             


Gly Ser Gly Pro Ala Asn His Ala Gly Gly Ala Gly Ala His Pro Gly 
    210                 215                 220                 


Trp Pro Gln Ala Ser Ala Asp Ser Pro Pro Tyr Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ala Ala Gly Gly Gly Ala Ala Gly Pro Gly Gly Ala Gly Ser Ala Ala 
                245                 250                 255     


Ala His Val Ser Ala Arg Phe Pro Tyr Ser Pro Ser Pro Pro Met Ala 
            260                 265                 270         


Asn Gly Ala Ala Arg Glu Pro Gly Gly Tyr Ala Ala Ala Gly Ser Gly 
        275                 280                 285             


Gly Ala Gly Gly Val Ser Gly Gly Gly Ser Ser Leu Ala Ala Met Gly 
    290                 295                 300                 


Gly Arg Glu Pro Gln Tyr Ser Ser Leu Ser Ala Ala Arg Pro Leu Asn 
305                 310                 315                 320 


Gly Thr Tyr His His His His His His His His His His Pro Ser Pro 
                325                 330                 335     


Tyr Ser Pro Tyr Val Gly Ala Pro Leu Thr Pro Ala Trp Pro Ala Gly 
            340                 345                 350         


Pro Phe Glu Thr Pro Val Leu His Ser Leu Gln Ser Arg Ala Gly Ala 
        355                 360                 365             


Pro Leu Pro Val Pro Arg Gly Pro Ser Ala Asp Leu Leu Glu Asp Leu 
    370                 375                 380                 


Ser Glu Ser Arg Glu Cys Val Asn Cys Gly Ser Ile Gln Thr Pro Leu 
385                 390                 395                 400 


Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly Leu 
                405                 410                 415     


Tyr Ser Lys Met Asn Gly Leu Ser Arg Pro Leu Ile Lys Pro Gln Lys 
            420                 425                 430         


Arg Val Pro Ser Ser Arg Arg Leu Gly Leu Ser Cys Ala Asn Cys His 
        435                 440                 445             


Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly Glu Pro Val 
    450                 455                 460                 


Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val Pro Arg Pro 
465                 470                 475                 480 


Leu Ala Met Lys Lys Glu Gly Ile Gln Thr Arg Lys Arg Lys Pro Lys 
                485                 490                 495     


Asn Ile Asn Lys Ser Lys Thr Cys Ser Gly Asn Ser Asn Asn Ser Ile 
            500                 505                 510         


Pro Met Thr Pro Thr Ser Thr Ser Ser Asn Ser Asp Asp Cys Ser Lys 
        515                 520                 525             


Asn Thr Ser Pro Thr Thr Gln Pro Thr Ala Ser Gly Ala Gly Ala Pro 
    530                 535                 540                 


Val Met Thr Gly Ala Gly Glu Ser Thr Asn Pro Glu Asn Ser Glu Leu 
545                 550                 555                 560 


Lys Tyr Ser Gly Gln Asp Gly Leu Tyr Ile Gly Val Ser Leu Ala Ser 
                565                 570                 575     


Pro Ala Glu Val Thr Ser Ser Val Arg Pro Asp Ser Trp Cys Ala Leu 
            580                 585                 590         


Ala Leu Ala 
        595 


<210>  3602
<211>  1584
<212>  DNA
<213>  Homosapiens

<400>  3602
gcgtccccca caccacagac ccgcgccgcc gacgacccag cagccgccat gcgtctgctc     60

cgaggtgtgt ttgtagttgc tgctaagcga acgccctttg gagcttacgg aggccttctg    120

aaagacttca ctgctactga cttgtctgaa tttgctgcca aggctgcctt gtctgctggc    180

aaagtctcac ctgaaacagt tgacagtgtg attatgggca atgtcctgca gagttcttca    240

gatgctatat atttggcaag gcatgttggt ttgcgtgtgg gaatcccaaa ggagacccca    300

gctctcacga ttaataggct ctgtggttct ggttttcagt ccattgtgaa tggatgtcag    360

gaaatttgtg ttaaagaagc tgaagttgtt ttatgtggag gaaccgaaag catgagccaa    420

gctccctact gtgtcagaaa tgtgcgtttt ggaaccaagc ttggatcaga tatcaagctg    480

gaagattctt tatgggtatc attaacagat cagcatgtcc agctccccat ggcaatgact    540

gcagagaatc ttactgtaaa acacaaaata agcagagaag aatgtgacaa atatgccctg    600

cagtcacagc agagatggaa agctgctaat gatgctggct actttaatga tgaaatggca    660

ccaattgaag tgaagacaaa gaaaggaaaa cagacaatgc aggtagacga gcatgctcgg    720

ccccaaacca ccctggaaca gttacagaaa cttcctccag tattcaagaa agatggaact    780

gttactgcag ggaatgcatc gggtgtagct gatggtgctg gagctgttat catagctagt    840

gaagatgctg ttaagaaaca taacttcaca ccactggcaa gaattgtggg ctactttgta    900

tctggatgtg atccctctat catgggtatt ggtcctgtcc ctgctatcag tggggcactg    960

aagaaagcag gactgagtct taaggacatg gatttggtag aggtgaatga agcttttgct   1020

ccccagtact tggctgttga gaggagtttg gatcttgaca taagtaaaac caatgtgaat   1080

ggaggagcca ttgctttggg tcacccactg ggaggatctg gatcaagaat tactgcacac   1140

ctggttcacg aattaaggcg tcgaggtgga aaatatgccg ttggatcagc ttgcattgga   1200

ggtggccaag gtattgctgt catcattcag agcacagcct gaagagacca gtgagctcac   1260

tgtgacccat ccttactcta cttggccagg ccacagtaaa acaagtgacc ttcagagcag   1320

ctgccacaac tggccatgcc ctgccattga aacagtgatt aagtttgatc aagccatggt   1380

gacacaaaaa tgcattgatc atgaatagga gcccatgcta gaagtacatt ctctcagatt   1440

tgaaccagtg aaatatgatg tatttctgag ctaaaactca actatagaag acattaaaag   1500

aaatcgtatt cttgccaagt aaccaccact tctgccttag ataatatgat tataaggaaa   1560

tcaaataaat gttgccttaa cttc                                          1584


<210>  3603
<211>  397
<212>  PRT
<213>  Homosapiens

<400>  3603

Met Arg Leu Leu Arg Gly Val Phe Val Val Ala Ala Lys Arg Thr Pro 
1               5                   10                  15      


Phe Gly Ala Tyr Gly Gly Leu Leu Lys Asp Phe Thr Ala Thr Asp Leu 
            20                  25                  30          


Ser Glu Phe Ala Ala Lys Ala Ala Leu Ser Ala Gly Lys Val Ser Pro 
        35                  40                  45              


Glu Thr Val Asp Ser Val Ile Met Gly Asn Val Leu Gln Ser Ser Ser 
    50                  55                  60                  


Asp Ala Ile Tyr Leu Ala Arg His Val Gly Leu Arg Val Gly Ile Pro 
65                  70                  75                  80  


Lys Glu Thr Pro Ala Leu Thr Ile Asn Arg Leu Cys Gly Ser Gly Phe 
                85                  90                  95      


Gln Ser Ile Val Asn Gly Cys Gln Glu Ile Cys Val Lys Glu Ala Glu 
            100                 105                 110         


Val Val Leu Cys Gly Gly Thr Glu Ser Met Ser Gln Ala Pro Tyr Cys 
        115                 120                 125             


Val Arg Asn Val Arg Phe Gly Thr Lys Leu Gly Ser Asp Ile Lys Leu 
    130                 135                 140                 


Glu Asp Ser Leu Trp Val Ser Leu Thr Asp Gln His Val Gln Leu Pro 
145                 150                 155                 160 


Met Ala Met Thr Ala Glu Asn Leu Thr Val Lys His Lys Ile Ser Arg 
                165                 170                 175     


Glu Glu Cys Asp Lys Tyr Ala Leu Gln Ser Gln Gln Arg Trp Lys Ala 
            180                 185                 190         


Ala Asn Asp Ala Gly Tyr Phe Asn Asp Glu Met Ala Pro Ile Glu Val 
        195                 200                 205             


Lys Thr Lys Lys Gly Lys Gln Thr Met Gln Val Asp Glu His Ala Arg 
    210                 215                 220                 


Pro Gln Thr Thr Leu Glu Gln Leu Gln Lys Leu Pro Pro Val Phe Lys 
225                 230                 235                 240 


Lys Asp Gly Thr Val Thr Ala Gly Asn Ala Ser Gly Val Ala Asp Gly 
                245                 250                 255     


Ala Gly Ala Val Ile Ile Ala Ser Glu Asp Ala Val Lys Lys His Asn 
            260                 265                 270         


Phe Thr Pro Leu Ala Arg Ile Val Gly Tyr Phe Val Ser Gly Cys Asp 
        275                 280                 285             


Pro Ser Ile Met Gly Ile Gly Pro Val Pro Ala Ile Ser Gly Ala Leu 
    290                 295                 300                 


Lys Lys Ala Gly Leu Ser Leu Lys Asp Met Asp Leu Val Glu Val Asn 
305                 310                 315                 320 


Glu Ala Phe Ala Pro Gln Tyr Leu Ala Val Glu Arg Ser Leu Asp Leu 
                325                 330                 335     


Asp Ile Ser Lys Thr Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His 
            340                 345                 350         


Pro Leu Gly Gly Ser Gly Ser Arg Ile Thr Ala His Leu Val His Glu 
        355                 360                 365             


Leu Arg Arg Arg Gly Gly Lys Tyr Ala Val Gly Ser Ala Cys Ile Gly 
    370                 375                 380                 


Gly Gly Gln Gly Ile Ala Val Ile Ile Gln Ser Thr Ala 
385                 390                 395         


<210>  3604
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3604
ccgtagctgc gccgccgcgg cgggagtaaa ggtcgcgccg ccgggagcga gccggccgcg     60

gcgcctgcgg gaagccggcg gggcaggtcg gagaagagcg agaagatcga gaaactccag    120

gccagcccgg gaacatggcg ccaggcgggc cagccgcgga ctgagagccg cggggcagcc    180

aggagccggg gcccgagccc cgcccggccc gggccatgtc ggtgggcgag ctctacagcc    240

agtgcacaag ggtctggatc cctgaccctg atgaggtatg gcgctcagct gagttaacca    300

aggactacaa agaaggagac aagagcctac agctcagact ggaggatgaa acgattctgg    360

aatacccaat tgatgtacaa cgcaaccagc tgcccttctt acggaatcca gatatcttgg    420

tgggagaaaa tgacctgact gcccttagct atcttcatga gcctgcagtt ttgcataatt    480

tgaaggtccg tttcctggag tccaaccata tctacactta ctgtggtatc gtacttgttg    540

ccattaatcc ttatgaacag ttgccaatct atggacaaga tgtcatctat acctacagtg    600

gccaaaacat gggagacatg gacccccaca tctttgctgt ggcagaagaa gcctacaagc    660

agatggccag agatgagaag aatcagtcca tcatagtcag tggggagtct ggagccggga    720

agacggtatc agccaagtat gccatgcgct atttcgccac cgttggtggc tcggccagtg    780

aaaccaacat cgaagagaag gtgctggcat ccagtcccat catggaggcc attggaaatg    840

ccaagaccac ccgcaatgac aacagcagcc gttttggcaa gtacatccag attggctttg    900

acaaaaggta ccacatcatc ggggccaaca tgaggactta cctcttggag aagtccagag    960

tggtcttcca ggcagatgat gagaggaatt accacatctt ttaccagctc tgtgctgctg   1020

ccggtcttcc agaatttaaa gagcttgcac taacaagtgc agaggacttt ttctatacat   1080

cacagggagg agacacttcc atcgagggtg tggacgatgc tgaggacttt gagaagactc   1140

gacaagcctt cacactcctc ggagtgaaag agtcccatca gatgagcatt tttaagataa   1200

ttgcttctat cttgcacctt ggaagtgtgg cgattcaggc tgagcgtgat ggtgattcct   1260

gtagtatatc accccaggat gtatacctaa gcaacttctg ccgactgcta ggggtggagc   1320

acagtcagat ggagcactgg ctgtgtcatc gcaagctggt caccacctcg gagacctacg   1380

tcaagaccat gtccctgcag caggtgatca atgcgcgcaa cgccctggcg aagcacatct   1440

atgcccagtt gttcggctgg attgtggagc acatcaacaa ggccctgcac acctccctca   1500

agcagcactc cttcatcggg gtcctggaca tctatgggtt tgagacattt gaggtaaaca   1560

gctttgagca gttctgtatc aactatgcaa atgaaaagct ccagcagcag ttcaactcgc   1620

atgttttcaa actggagcaa gaagaataca tgaaggaaca gatcccttgg accctgattg   1680

atttttatga taaccaacct tgtatcgacc tcattgaagc caagctgggt atcttggacc   1740

tgttggatga agaatgtaag gtccccaaag gaactgacca gaactgggct cagaagctct   1800

atgaccggca ctccagcagc cagcacttcc agaagccccg catgtccaac acggccttca   1860

tcatcgtcca ctttgcagac aaggtggagt acctctctga tggttttctg gagaaaaaca   1920

gagacacggt gtatgaagag cagatcaata tcctgaaggc cagcaagttc ccactagtgg   1980

ctgacttgtt tcatgatgac aaggaccctg ttcctgccac cacccctggg aaggggtcat   2040

cttcgaagat cagcgtccgt tctgccagac cccccatgaa agtctccaac aaggagcaca   2100

agaaaaccgt tggccaccag ttccgtacct ccctgcatct gctcatggag accctgaatg   2160

ccacgacacc tcactatgtc cgctgcatca agcccaacga tgagaagctc ccctttcact   2220

ttgacccaaa gagagcagtg cagcaactca gagcctgcgg ggtgttggag acgattcgaa   2280

tcagtgcagc tggctaccca tccaggtggg cctaccatga ctttttcaac cggtatcggg   2340

tgctggtcaa gaagagagag ctcgccaaca cagacaaaaa ggccatctgc aggtctgtcc   2400

tggagaacct catcaaggac cccgacaagt tccagtttgg ccgcaccaag atcttctttc   2460

gagcaggcca ggtggcctac ctggagaagc tgcgggctga caagttccgg acagccacca   2520

tcatgatcca gaaaactgtc cggggatggc tgcagaaggt gaaatatcac aggctgaagg   2580

gggctacctt aaccctgcag aggtactgcc ggggacacct ggcccgcagg ctggctgagc   2640

acctgcggag gatcagagcg gctgtggtgc tccagaaaca ttaccgcatg cagagggccc   2700

gccaggccta ccagagggtc cgcagagctg ccgttgttat ccaggccttc acccgggcca   2760

tgtttgtgcg gagaacctac cgccaggtcc tcatggagca caaggccacc accatccaga   2820

agcacgtgcg gggctggatg gcacgcaggc acttccagcg gctgcgggat gcagccattg   2880

tcatccagtg tgccttccgg atgctcaagg ccaggcggga gctgaaggcc ctcaggattg   2940

aggcccgctc agcagagcat ctgaaacgtc tcaacgtggg catggagaac aaggtggtcc   3000

agctgcagcg gaagatcgat gagcagaaca aagagttcaa gacactttca gagcagttgt   3060

ccgtgaccac ctcaacatac accatggagg tagagcggct gaagaaggag ctggtgcact   3120

accagcagag cccaggtgag gacaccagcc tcaggctgca ggaggaggtg gagagcctgc   3180

gcacagagct gcagagggcc cactcggagc gcaagatctt ggaggacgcc cacagcaggg   3240

agaaagatga gctgaggaag cgagttgcag acctggagca agaaaatgct ctcttgaaag   3300

atgagaaaga acagctcaac aaccaaatcc tgtgccagtc taaagatgaa tttgcccaga   3360

actctgtgaa ggaaaatctc atgaagaaag aactggagga ggagcgatcc cggtaccaga   3420

accttgtgaa ggaatattca cagttggagc agagatacga caaccttcgg gatgaaatga   3480

ccatcataaa gcaaactcca ggtcataggc ggaacccatc aaaccaaagt agcttagaat   3540

ctgactccaa ttacccctcc atctccacat ctgagatcgg agacactgag gatgccctcc   3600

agcaggtgga ggaaattggc ctggagaagg cagccatgga catgacggtc ttcctgaagc   3660

tgcagaagag agtacgggag ctggagcagg agaggaaaaa gctgcaagtg cagctggaga   3720

agagagaaca gcaggacagc aagaaagtcc aggcggaacc accacagact gacatagatt   3780

tggacccgaa tgcagatctg gcctacaata gtctgaagag gcaagagctg gagtcagaga   3840

acaaaaagct gaagaatgac ctgaatgagc tgaggaaagc cgtggccgac caagccacgc   3900

agaataactc cagccacggc tccccagata gctacagcct cctgctgaac cagctcaagc   3960

tggcccacga ggagctcgag gtgcgcaagg aggaggtgct catcctcagg acccagatcg   4020

tgagcgccga ccagcggcga ctcgccggca ggaacgcgga gccgaacatt aatgccagat   4080

caagttggcc taacagtgaa aagcatgttg accaggagga tgccattgag gcctatcacg   4140

gggtctgcca gacaaacagc aagactgagg attggggata tttaaatgaa gatggagaac   4200

tcggcttggc ctaccaaggc ctaaagcaag ttgccaggct gctggaggct cagctgcagg   4260

cccagagcct ggagcatgag gaggaggtgg agcatctcaa ggctcagctc gaggccctga   4320

aggaggagat ggacaaacag cagcagacct tctgccagac gctactgctc tccccagagg   4380

cccaggtgga attcggcgtt cagcaggaaa tatcccggct gaccaacgag aatctggacc   4440

ttaaagaact ggtagaaaag ctggaaaaga atgagaggaa gctcaaaaag caactgaaga   4500

tttacatgaa gaaagcccag gacctagaag ctgcccaggc attggcccag agtgagagga   4560

agcgccatga gctcaacagg caggtcacgg tccagcggaa agagaaggat ttccagggca   4620

tgctggagta ccacaaagag gacgaggccc tcctcatccg gaacctggtg acagacttga   4680

agccccagat gctgtcgggc acagtgccct gtctccccgc ctacatcctc tacatgtgca   4740

tccggcacgc ggactacacc aacgacgatc tcaaggtgca ctccctgctg acctccacca   4800

tcaacggcat taagaaagtc ctgaaaaagc acaatgatga ctttgagatg acgtcattct   4860

ggttatccaa cacctgccgc cttcttcact gtctgaagca gtacagcggg gatgagggct   4920

tcatgactca gaacactgca aagcagaatg aacactgtct taagaatttt gacctcaccg   4980

aataccgtca ggtgctgagt gacctttcca ttcagatcta ccagcagctc attaaaattg   5040

ccgagggcgt gttacagccg atgatagttt ctgccatgtt ggaaaatgag agcattcagg   5100

gtctatctgg tgtgaagccc accggctacc ggaagcgctc ctccagcatg gcagatgggg   5160

ataactcata ctgcctggaa gctatcatcc gccagatgaa tgcctttcat acagtcatgt   5220

gtgaccaggg cttggaccct gagatcatcc tgcaggtatt caaacagctc ttctacatga   5280

tcaacgcagt gactcttaac aacctgctct tgcggaagga cgtctgctct tggagcacag   5340

gcatgcaact caggtacaat ataagtcagc ttgaggagtg gcttcgggga agaaaccttc   5400

accagagtgg agcagttcag accatggaac ctctgatcca agcagcccag ctcctgcaat   5460

taaagaagaa aacccaggag gacgcagagg ctatctgctc cctgtgtacc tccctcagca   5520

cccagcagat tgtcaaaatt ttaaaccttt atactcccct gaatgaattt gaagaacggg   5580

taacagtggc ctttatacga acaatccagg cacaactaca agagcggaat gaccctcagc   5640

aactgctatt agatgccaag cacatgtttc ctgttttgtt tccatttaat ccatcttctc   5700

taaccatgga ctcaatccac atcccagcgt gtctcaatct ggaattcctc aatgaagtct   5760

gaagatgcat gtttccagca ttagtttgat tcccaatgtg agcaagaagg aagtatatac   5820

agtaaagtaa attcaaggat ctgttaaatc tggtaaaagt agatcaaatc agagattgac   5880

agcctgtgga gggtgctgaa ctatacagaa ttagacacaa ctatgtcatt attttttgta   5940

cctactgctc agaataaaaa cacttgaaat atggaagatt ttaagtttga tttcagtcca   6000

acacatatac ataatttata gacaccaagc agtccccata gacatataaa aggtgtcaat   6060

tctataaaac gaagctgcct agttttgatc tttgcataga actagagaat gtccaaatta   6120

aaataccaaa tatatataag tcacataaat tgccttcaaa gggctttaac aaataatggt   6180

actaataacc atgataatgg catatactga catttcccaa agtttgcaaa ccataggtgt   6240

ggttgagttt gtggtgagat gttttaagaa caaaaatatg gggatgagac ttctgagaaa   6300

tattcccaaa atatttttta atggctgatt atacacagac agtggtgtaa ctgacctcca   6360

gaccagacat tttgagtact ggtttctgaa gcaaaattag aagtgccagt cctcagtgtg   6420

ctcaaacgct tttgtgttat cttgatttaa tggaagagat tattaaaatg ctgctatccc   6480

aaactccaag tgagaaagat ggaaaaatat tttgtttctg atgctagtcc atacactttc   6540

caagtcccac aaaactttca caaaaatgta tataagctaa atattagaaa cggataacaa   6600

acttgtttta tttatagatg taaaaaccaa acaagtcaat atgaaagctt ttaatctctt   6660

aataccatta agcttccagt aagagcatca cataatgctc tactgttcca gaaaccaaat   6720

agtaaaacaa actaaagttc gcacatcaga tcatctgaaa aaccttcaaa aataatcagt   6780

tcagggatat tatacaaaag tttgggtttt ttttttttaa gagaataaaa tggcttaggt   6840

caactttccc ttttcaggtt attttcaacg tttttcaaat ttagcacaca aaaaattgta   6900

aatatctctc ccacaaaata aggattttaa aaaagtaatt cagtaatata acaggcttag   6960

atgtttgctg ctcttagaat tttttttaac ttgtttttgg tttcttcaaa agcaagcatt   7020

caattggaaa cccatattct ttccacactt ttttttactg tcttttctgt atttcttgat   7080

agcagtatgc tgttcccata agaaaaaaat ggtatttgca aatcatggaa gaacagcctc   7140

tgtattacat tgagaaaata agatttatcc atgaattgga agtagaacag cctgccttca   7200

ccctctttta ctcaaccacc caacttaaaa ggctcttgga aacacagcac actccacgct   7260

accttctgca ctgtgccctt agagcacagc ttcctcagtt gttctctgca tctcctgggg   7320

cttaggccag tcttagcctg ggttaaggct gctgacattg tgttccaatc agttgtcatg   7380

ggcattatcc cctctacatc cacattaaac atgccggctt ctcttgggca tcggcagagc   7440

tgtgcctttt tctttcagtt acagttacat aatcactgac gtccatgaca cttacccatg   7500

gatccatgtg ctgacttcat ttagaaggcc aatctaaaac aactgggttt gtggctacct   7560

ctttaaagtt gtttgtgaag gataatttgt tttttaatgc actttagttt gaaagtgagt   7620

ctcttatgta aggaccatcc ttaaaagacc aaaaatgcct tgttagagtg ttaaggagtt   7680

ttgacatgca gtggttccac aaacacagtg gcttactatc cttatacact gtcttatacc   7740

atcattctct ccatctctct tggtcactac tctctgctgt cactggttaa tcactaggtg   7800

ccaagagctt actgaataaa agcttggcaa ttagaataaa tggggaggga aggaccttat   7860

gaatagtcca tttagcctaa gaaatggcag atttagttct tctcttccaa aagataaagg   7920

tatatcctgg aattgtactt aaaacttaca gatgactaac aaatatatac tttatatgta   7980

gttaatattt agatctgtct tatttaatac ttggaggcta gaagaagcat ctttagggga   8040

actatataat cttttgttag cattttctct gcattttaaa aaatcatttc aattcaaaca   8100

tttatcagtg tcatgaaatc agtaatgact ctttaacaat tcaggtttga actctgcatt   8160

agatgtctct ttaatttttt aatatttaaa at                                 8192


<210>  3605
<211>  1848
<212>  PRT
<213>  Homosapiens

<400>  3605

Met Ser Val Gly Glu Leu Tyr Ser Gln Cys Thr Arg Val Trp Ile Pro 
1               5                   10                  15      


Asp Pro Asp Glu Val Trp Arg Ser Ala Glu Leu Thr Lys Asp Tyr Lys 
            20                  25                  30          


Glu Gly Asp Lys Ser Leu Gln Leu Arg Leu Glu Asp Glu Thr Ile Leu 
        35                  40                  45              


Glu Tyr Pro Ile Asp Val Gln Arg Asn Gln Leu Pro Phe Leu Arg Asn 
    50                  55                  60                  


Pro Asp Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu 
65                  70                  75                  80  


His Glu Pro Ala Val Leu His Asn Leu Lys Val Arg Phe Leu Glu Ser 
                85                  90                  95      


Asn His Ile Tyr Thr Tyr Cys Gly Ile Val Leu Val Ala Ile Asn Pro 
            100                 105                 110         


Tyr Glu Gln Leu Pro Ile Tyr Gly Gln Asp Val Ile Tyr Thr Tyr Ser 
        115                 120                 125             


Gly Gln Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu 
    130                 135                 140                 


Glu Ala Tyr Lys Gln Met Ala Arg Asp Glu Lys Asn Gln Ser Ile Ile 
145                 150                 155                 160 


Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Lys Tyr Ala 
                165                 170                 175     


Met Arg Tyr Phe Ala Thr Val Gly Gly Ser Ala Ser Glu Thr Asn Ile 
            180                 185                 190         


Glu Glu Lys Val Leu Ala Ser Ser Pro Ile Met Glu Ala Ile Gly Asn 
        195                 200                 205             


Ala Lys Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile 
    210                 215                 220                 


Gln Ile Gly Phe Asp Lys Arg Tyr His Ile Ile Gly Ala Asn Met Arg 
225                 230                 235                 240 


Thr Tyr Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ala Asp Asp Glu 
                245                 250                 255     


Arg Asn Tyr His Ile Phe Tyr Gln Leu Cys Ala Ala Ala Gly Leu Pro 
            260                 265                 270         


Glu Phe Lys Glu Leu Ala Leu Thr Ser Ala Glu Asp Phe Phe Tyr Thr 
        275                 280                 285             


Ser Gln Gly Gly Asp Thr Ser Ile Glu Gly Val Asp Asp Ala Glu Asp 
    290                 295                 300                 


Phe Glu Lys Thr Arg Gln Ala Phe Thr Leu Leu Gly Val Lys Glu Ser 
305                 310                 315                 320 


His Gln Met Ser Ile Phe Lys Ile Ile Ala Ser Ile Leu His Leu Gly 
                325                 330                 335     


Ser Val Ala Ile Gln Ala Glu Arg Asp Gly Asp Ser Cys Ser Ile Ser 
            340                 345                 350         


Pro Gln Asp Val Tyr Leu Ser Asn Phe Cys Arg Leu Leu Gly Val Glu 
        355                 360                 365             


His Ser Gln Met Glu His Trp Leu Cys His Arg Lys Leu Val Thr Thr 
    370                 375                 380                 


Ser Glu Thr Tyr Val Lys Thr Met Ser Leu Gln Gln Val Ile Asn Ala 
385                 390                 395                 400 


Arg Asn Ala Leu Ala Lys His Ile Tyr Ala Gln Leu Phe Gly Trp Ile 
                405                 410                 415     


Val Glu His Ile Asn Lys Ala Leu His Thr Ser Leu Lys Gln His Ser 
            420                 425                 430         


Phe Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Glu Val Asn 
        435                 440                 445             


Ser Phe Glu Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln 
    450                 455                 460                 


Gln Phe Asn Ser His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys 
465                 470                 475                 480 


Glu Gln Ile Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Cys 
                485                 490                 495     


Ile Asp Leu Ile Glu Ala Lys Leu Gly Ile Leu Asp Leu Leu Asp Glu 
            500                 505                 510         


Glu Cys Lys Val Pro Lys Gly Thr Asp Gln Asn Trp Ala Gln Lys Leu 
        515                 520                 525             


Tyr Asp Arg His Ser Ser Ser Gln His Phe Gln Lys Pro Arg Met Ser 
    530                 535                 540                 


Asn Thr Ala Phe Ile Ile Val His Phe Ala Asp Lys Val Glu Tyr Leu 
545                 550                 555                 560 


Ser Asp Gly Phe Leu Glu Lys Asn Arg Asp Thr Val Tyr Glu Glu Gln 
                565                 570                 575     


Ile Asn Ile Leu Lys Ala Ser Lys Phe Pro Leu Val Ala Asp Leu Phe 
            580                 585                 590         


His Asp Asp Lys Asp Pro Val Pro Ala Thr Thr Pro Gly Lys Gly Ser 
        595                 600                 605             


Ser Ser Lys Ile Ser Val Arg Ser Ala Arg Pro Pro Met Lys Val Ser 
    610                 615                 620                 


Asn Lys Glu His Lys Lys Thr Val Gly His Gln Phe Arg Thr Ser Leu 
625                 630                 635                 640 


His Leu Leu Met Glu Thr Leu Asn Ala Thr Thr Pro His Tyr Val Arg 
                645                 650                 655     


Cys Ile Lys Pro Asn Asp Glu Lys Leu Pro Phe His Phe Asp Pro Lys 
            660                 665                 670         


Arg Ala Val Gln Gln Leu Arg Ala Cys Gly Val Leu Glu Thr Ile Arg 
        675                 680                 685             


Ile Ser Ala Ala Gly Tyr Pro Ser Arg Trp Ala Tyr His Asp Phe Phe 
    690                 695                 700                 


Asn Arg Tyr Arg Val Leu Val Lys Lys Arg Glu Leu Ala Asn Thr Asp 
705                 710                 715                 720 


Lys Lys Ala Ile Cys Arg Ser Val Leu Glu Asn Leu Ile Lys Asp Pro 
                725                 730                 735     


Asp Lys Phe Gln Phe Gly Arg Thr Lys Ile Phe Phe Arg Ala Gly Gln 
            740                 745                 750         


Val Ala Tyr Leu Glu Lys Leu Arg Ala Asp Lys Phe Arg Thr Ala Thr 
        755                 760                 765             


Ile Met Ile Gln Lys Thr Val Arg Gly Trp Leu Gln Lys Val Lys Tyr 
    770                 775                 780                 


His Arg Leu Lys Gly Ala Thr Leu Thr Leu Gln Arg Tyr Cys Arg Gly 
785                 790                 795                 800 


His Leu Ala Arg Arg Leu Ala Glu His Leu Arg Arg Ile Arg Ala Ala 
                805                 810                 815     


Val Val Leu Gln Lys His Tyr Arg Met Gln Arg Ala Arg Gln Ala Tyr 
            820                 825                 830         


Gln Arg Val Arg Arg Ala Ala Val Val Ile Gln Ala Phe Thr Arg Ala 
        835                 840                 845             


Met Phe Val Arg Arg Thr Tyr Arg Gln Val Leu Met Glu His Lys Ala 
    850                 855                 860                 


Thr Thr Ile Gln Lys His Val Arg Gly Trp Met Ala Arg Arg His Phe 
865                 870                 875                 880 


Gln Arg Leu Arg Asp Ala Ala Ile Val Ile Gln Cys Ala Phe Arg Met 
                885                 890                 895     


Leu Lys Ala Arg Arg Glu Leu Lys Ala Leu Arg Ile Glu Ala Arg Ser 
            900                 905                 910         


Ala Glu His Leu Lys Arg Leu Asn Val Gly Met Glu Asn Lys Val Val 
        915                 920                 925             


Gln Leu Gln Arg Lys Ile Asp Glu Gln Asn Lys Glu Phe Lys Thr Leu 
    930                 935                 940                 


Ser Glu Gln Leu Ser Val Thr Thr Ser Thr Tyr Thr Met Glu Val Glu 
945                 950                 955                 960 


Arg Leu Lys Lys Glu Leu Val His Tyr Gln Gln Ser Pro Gly Glu Asp 
                965                 970                 975     


Thr Ser Leu Arg Leu Gln Glu Glu Val Glu Ser Leu Arg Thr Glu Leu 
            980                 985                 990         


Gln Arg Ala His Ser Glu Arg Lys  Ile Leu Glu Asp Ala  His Ser Arg 
        995                 1000                 1005             


Glu Lys  Asp Glu Leu Arg Lys  Arg Val Ala Asp Leu  Glu Gln Glu 
    1010                 1015                 1020             


Asn Ala  Leu Leu Lys Asp Glu  Lys Glu Gln Leu Asn  Asn Gln Ile 
    1025                 1030                 1035             


Leu Cys  Gln Ser Lys Asp Glu  Phe Ala Gln Asn Ser  Val Lys Glu 
    1040                 1045                 1050             


Asn Leu  Met Lys Lys Glu Leu  Glu Glu Glu Arg Ser  Arg Tyr Gln 
    1055                 1060                 1065             


Asn Leu  Val Lys Glu Tyr Ser  Gln Leu Glu Gln Arg  Tyr Asp Asn 
    1070                 1075                 1080             


Leu Arg  Asp Glu Met Thr Ile  Ile Lys Gln Thr Pro  Gly His Arg 
    1085                 1090                 1095             


Arg Asn  Pro Ser Asn Gln Ser  Ser Leu Glu Ser Asp  Ser Asn Tyr 
    1100                 1105                 1110             


Pro Ser  Ile Ser Thr Ser Glu  Ile Gly Asp Thr Glu  Asp Ala Leu 
    1115                 1120                 1125             


Gln Gln  Val Glu Glu Ile Gly  Leu Glu Lys Ala Ala  Met Asp Met 
    1130                 1135                 1140             


Thr Val  Phe Leu Lys Leu Gln  Lys Arg Val Arg Glu  Leu Glu Gln 
    1145                 1150                 1155             


Glu Arg  Lys Lys Leu Gln Val  Gln Leu Glu Lys Arg  Glu Gln Gln 
    1160                 1165                 1170             


Asp Ser  Lys Lys Val Gln Ala  Glu Pro Pro Gln Thr  Asp Ile Asp 
    1175                 1180                 1185             


Leu Asp  Pro Asn Ala Asp Leu  Ala Tyr Asn Ser Leu  Lys Arg Gln 
    1190                 1195                 1200             


Glu Leu  Glu Ser Glu Asn Lys  Lys Leu Lys Asn Asp  Leu Asn Glu 
    1205                 1210                 1215             


Leu Arg  Lys Ala Val Ala Asp  Gln Ala Thr Gln Asn  Asn Ser Ser 
    1220                 1225                 1230             


His Gly  Ser Pro Asp Ser Tyr  Ser Leu Leu Leu Asn  Gln Leu Lys 
    1235                 1240                 1245             


Leu Ala  His Glu Glu Leu Glu  Val Arg Lys Glu Glu  Val Leu Ile 
    1250                 1255                 1260             


Leu Arg  Thr Gln Ile Val Ser  Ala Asp Gln Arg Arg  Leu Ala Gly 
    1265                 1270                 1275             


Arg Asn  Ala Glu Pro Asn Ile  Asn Ala Arg Ser Ser  Trp Pro Asn 
    1280                 1285                 1290             


Ser Glu  Lys His Val Asp Gln  Glu Asp Ala Ile Glu  Ala Tyr His 
    1295                 1300                 1305             


Gly Val  Cys Gln Thr Asn Ser  Lys Thr Glu Asp Trp  Gly Tyr Leu 
    1310                 1315                 1320             


Asn Glu  Asp Gly Glu Leu Gly  Leu Ala Tyr Gln Gly  Leu Lys Gln 
    1325                 1330                 1335             


Val Ala  Arg Leu Leu Glu Ala  Gln Leu Gln Ala Gln  Ser Leu Glu 
    1340                 1345                 1350             


His Glu  Glu Glu Val Glu His  Leu Lys Ala Gln Leu  Glu Ala Leu 
    1355                 1360                 1365             


Lys Glu  Glu Met Asp Lys Gln  Gln Gln Thr Phe Cys  Gln Thr Leu 
    1370                 1375                 1380             


Leu Leu  Ser Pro Glu Ala Gln  Val Glu Phe Gly Val  Gln Gln Glu 
    1385                 1390                 1395             


Ile Ser  Arg Leu Thr Asn Glu  Asn Leu Asp Leu Lys  Glu Leu Val 
    1400                 1405                 1410             


Glu Lys  Leu Glu Lys Asn Glu  Arg Lys Leu Lys Lys  Gln Leu Lys 
    1415                 1420                 1425             


Ile Tyr  Met Lys Lys Ala Gln  Asp Leu Glu Ala Ala  Gln Ala Leu 
    1430                 1435                 1440             


Ala Gln  Ser Glu Arg Lys Arg  His Glu Leu Asn Arg  Gln Val Thr 
    1445                 1450                 1455             


Val Gln  Arg Lys Glu Lys Asp  Phe Gln Gly Met Leu  Glu Tyr His 
    1460                 1465                 1470             


Lys Glu  Asp Glu Ala Leu Leu  Ile Arg Asn Leu Val  Thr Asp Leu 
    1475                 1480                 1485             


Lys Pro  Gln Met Leu Ser Gly  Thr Val Pro Cys Leu  Pro Ala Tyr 
    1490                 1495                 1500             


Ile Leu  Tyr Met Cys Ile Arg  His Ala Asp Tyr Thr  Asn Asp Asp 
    1505                 1510                 1515             


Leu Lys  Val His Ser Leu Leu  Thr Ser Thr Ile Asn  Gly Ile Lys 
    1520                 1525                 1530             


Lys Val  Leu Lys Lys His Asn  Asp Asp Phe Glu Met  Thr Ser Phe 
    1535                 1540                 1545             


Trp Leu  Ser Asn Thr Cys Arg  Leu Leu His Cys Leu  Lys Gln Tyr 
    1550                 1555                 1560             


Ser Gly  Asp Glu Gly Phe Met  Thr Gln Asn Thr Ala  Lys Gln Asn 
    1565                 1570                 1575             


Glu His  Cys Leu Lys Asn Phe  Asp Leu Thr Glu Tyr  Arg Gln Val 
    1580                 1585                 1590             


Leu Ser  Asp Leu Ser Ile Gln  Ile Tyr Gln Gln Leu  Ile Lys Ile 
    1595                 1600                 1605             


Ala Glu  Gly Val Leu Gln Pro  Met Ile Val Ser Ala  Met Leu Glu 
    1610                 1615                 1620             


Asn Glu  Ser Ile Gln Gly Leu  Ser Gly Val Lys Pro  Thr Gly Tyr 
    1625                 1630                 1635             


Arg Lys  Arg Ser Ser Ser Met  Ala Asp Gly Asp Asn  Ser Tyr Cys 
    1640                 1645                 1650             


Leu Glu  Ala Ile Ile Arg Gln  Met Asn Ala Phe His  Thr Val Met 
    1655                 1660                 1665             


Cys Asp  Gln Gly Leu Asp Pro  Glu Ile Ile Leu Gln  Val Phe Lys 
    1670                 1675                 1680             


Gln Leu  Phe Tyr Met Ile Asn  Ala Val Thr Leu Asn  Asn Leu Leu 
    1685                 1690                 1695             


Leu Arg  Lys Asp Val Cys Ser  Trp Ser Thr Gly Met  Gln Leu Arg 
    1700                 1705                 1710             


Tyr Asn  Ile Ser Gln Leu Glu  Glu Trp Leu Arg Gly  Arg Asn Leu 
    1715                 1720                 1725             


His Gln  Ser Gly Ala Val Gln  Thr Met Glu Pro Leu  Ile Gln Ala 
    1730                 1735                 1740             


Ala Gln  Leu Leu Gln Leu Lys  Lys Lys Thr Gln Glu  Asp Ala Glu 
    1745                 1750                 1755             


Ala Ile  Cys Ser Leu Cys Thr  Ser Leu Ser Thr Gln  Gln Ile Val 
    1760                 1765                 1770             


Lys Ile  Leu Asn Leu Tyr Thr  Pro Leu Asn Glu Phe  Glu Glu Arg 
    1775                 1780                 1785             


Val Thr  Val Ala Phe Ile Arg  Thr Ile Gln Ala Gln  Leu Gln Glu 
    1790                 1795                 1800             


Arg Asn  Asp Pro Gln Gln Leu  Leu Leu Asp Ala Lys  His Met Phe 
    1805                 1810                 1815             


Pro Val  Leu Phe Pro Phe Asn  Pro Ser Ser Leu Thr  Met Asp Ser 
    1820                 1825                 1830             


Ile His  Ile Pro Ala Cys Leu  Asn Leu Glu Phe Leu  Asn Glu Val 
    1835                 1840                 1845             


<210>  3606
<211>  4082
<212>  DNA
<213>  Homosapiens

<400>  3606
acattctgct gctgctgcag agtgatgatt tttaacagac cagaacttac acatctaaat     60

gagtgttgtt gttcagtgaa gtcaccttag gacaatgatt taaataacac cgcgatttct    120

caagaagttt ggaacttctc ttatggttga gttcaaagcc attttatgtt atatgtggcc    180

caaacaagtt ttattagtac aattaaatct ttattgagga cttttgatgg accacatagt    240

gaacttggac tgggaatcaa aagaatggta aggcagggtg tctgccttca ctgtgcctgc    300

agtctggctg agatgcacat gtgagccaca ctagcacaag ccagcatgca ctggcctgtc    360

acaagagagt gcacaagggt ctggatccct gaccctgatg aggtatggcg ctcagctgag    420

ttaaccaagg actacaaaga aggagacaag agcctacagc tcagactgga ggatgaaacg    480

attctggaat acccaattga tgtacaacgc aaccagctgc ccttcttacg gaatccagat    540

atcttggtgg gagaaaatga cctgactgcc cttagctatc ttcatgagcc tgcagttttg    600

cataatttga aggtccgttt cctggagtcc aaccatatct acacttactg tggtatcgta    660

cttgttgcca ttaatcctta tgaacagttg ccaatctatg gacaagatgt catctatacc    720

tacagtggcc aaaacatggg agacatggac ccccacatct ttgctgtggc agaagaagcc    780

tacaagcaga tggccagaga tgagaagaat cagtccatca tagtcagtgg ggagtctgga    840

gccgggaaga cggtatcagc caagtatgcc atgcgctatt tcgccaccgt tggtggctcg    900

gccagtgaaa ccaacatcga agagaaggtg ctggcatcca gtcccatcat ggaggccatt    960

ggaaatgcca agaccacccg caatgacaac agcagccgtt ttggcaagta catccagatt   1020

ggctttgaca aaaggtacca catcatcggg gccaacatga ggacttacct cttggagaag   1080

tccagagtgg tcttccaggc agatgatgag aggaattacc acatctttta ccagctctgt   1140

gctgctgccg gtcttccaga atttaaagag cttgcactaa caagtgcaga ggactttttc   1200

tatacatcac agggaggaga cacttccatc gagggtgtgg acgatgctga ggactttgag   1260

aagactcgac aagccttcac actcctcgga gtgaaagagt cccatcagat gagcattttt   1320

aagataattg cttctatctt gcaccttgga agtgtggcga ttcaggctga gcgtgatggt   1380

gattcctgta gtatatcacc ccaggatgta tacctaagca acttctgccg actgctaggg   1440

gtggagcaca gtcagatgga gcactggctg tgtcatcgca agctggtcac cacctcggag   1500

acctacgtca agaccatgtc cctgcagcag gtgatcaatg cgcgcaacgc cctggcgaag   1560

cacatctatg cccagttgtt cggctggatt gtggagcaca tcaacaaggc cctgcacacc   1620

tccctcaagc agcactcctt catcggggtc ctggacatct atgggtttga gacatttgag   1680

gtaaacagct ttgagcagtt ctgtatcaac tatgcaaatg aaaagctcca gcagcagttc   1740

aactcgcatg ttttcaaact ggagcaagaa gaatacatga aggaacagat cccttggacc   1800

ctgattgatt tttatgataa ccaaccttgt atcgacctca ttgaagccaa gctgggtatc   1860

ttggacctgt tggatgaaga atgtaaggtc cccaaaggaa ctgaccagaa ctgggctcag   1920

aagctctatg accggcactc cagcagccag cacttccaga agccccgcat gtccaacacg   1980

gccttcatca tcgtccactt tgcagacaag gtggagtacc tctctgatgg ttttctggag   2040

aaaaacagag acacggtgta tgaagagcag atcaatatcc tgaaggccag caagttccca   2100

ctagtggctg acttgtttca tgatgacaag gaccctgttc ctgccaccac ccctgggaag   2160

gggtcatctt cgaagatcag cgtccgttct gccagacccc ccatgaaagt ctccaacaag   2220

gagcacaaga aaaccgttgg ccaccaggtc tgtacctccc tcagcaccca gcagattgtc   2280

aaaattttaa acctttatac tcccctgaat gaatttgaag aacgggtaac agtggccttt   2340

atacgaacaa tccaggcaca actacaagag cggaatgacc ctcagcaact gctattagat   2400

gccaagcaca tgtttcctgt tttgtttcca tttaatccat cttctctaac catggactca   2460

atccacatcc cagcgtgtct caatctggaa ttcctcaatg aagtctgaag atgcatgttt   2520

ccagcattag tttgattccc aatgtgagca agaaggaagt atatacagta aagtaaattc   2580

aaggatctgt taaatctggt aaaagtagat caaatcagag attgacagcc tgtggagggt   2640

gctgaactat acagaattag acacaactat gtcattattt tttgtaccta ctgctcagaa   2700

taaaaacact tgaaatatgg aagattttaa gtttgatttc agtccaacac atatacataa   2760

tttatagaca ccaagcagtc cccatagaca tataaaaggt gtcaattcta taaaacgaag   2820

ctgcctagtt ttgatctttg catagaacta gagaatgtcc aaattaaaat accaaatata   2880

tataagtcac ataaattgcc ttcaaagggc tttaacaaat aatggtacta ataaccatga   2940

taatggcata tactgacatt tcccaaagtt tgcaaaccat aggtgtggtt gagtttgtgg   3000

tgagatgttt taagaacaaa aatatgggga tgagacttct gagaaatatt cccaaaatat   3060

tttttaatgg ctgattatac acagacagtg gtgtaactga cctccagacc agacattttg   3120

agtactggtt tctgaagcaa aattagaagt gccagtcctc agtgtgctca aacgcttttg   3180

tgttatcttg atttaatgga agagattatt aaaatgctgc tatcccaaac tccaagtgag   3240

aaagatggaa aaatattttg tttctgatgc tagtccatac actttccaag tcccacaaaa   3300

ctttcacaaa aatgtatata agctaaatat tagaaacgga taacaaactt gttttattta   3360

tagatgtaaa aaccaaacaa gtcaatatga aagcttttaa tctcttaata ccattaagct   3420

tccagtaaga gcatcacata atgctctact gttccagaaa ccaaatagta aaacaaacta   3480

aagttcgcac atcagatcat ctgaaaaacc ttcaaaaata atcagttcag ggatattata   3540

caaaagtttg ggtttttttt ttttaagaga ataaaatggc ttaggtcaac tttccctttt   3600

caggttattt tcaacgtttt tcaaatttag cacacaaaaa attgtaaata tctctcccac   3660

aaaataagga ttttaaaaaa gtaattcagt aatataacag gcttagatgt ttgctgctct   3720

tagaattttt tttaacttgt ttttggtttc ttcaaaagca agcattcaat tggaaaccca   3780

tattctttcc acactttttt ttactgtctt ttctgtattt cttgatagca gtatgctgtt   3840

cccataagaa aaaaatggta tttgcaaatc atggaagaac agcctctgta ttacattgag   3900

aaaataagat ttatccatga attggaagta gaacagcctg ccttcaccct cttttactca   3960

accacccaac ttaaaaggct cttggaaaca cagcacactc cacgctacct tctgcactgt   4020

gcccttagag cacagcttcc tcagttgttc tctgcatctc ctggggctta ggccagtctt   4080

ag                                                                  4082


<210>  3607
<211>  720
<212>  PRT
<213>  Homosapiens

<400>  3607

Met His Trp Pro Val Thr Arg Glu Cys Thr Arg Val Trp Ile Pro Asp 
1               5                   10                  15      


Pro Asp Glu Val Trp Arg Ser Ala Glu Leu Thr Lys Asp Tyr Lys Glu 
            20                  25                  30          


Gly Asp Lys Ser Leu Gln Leu Arg Leu Glu Asp Glu Thr Ile Leu Glu 
        35                  40                  45              


Tyr Pro Ile Asp Val Gln Arg Asn Gln Leu Pro Phe Leu Arg Asn Pro 
    50                  55                  60                  


Asp Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu His 
65                  70                  75                  80  


Glu Pro Ala Val Leu His Asn Leu Lys Val Arg Phe Leu Glu Ser Asn 
                85                  90                  95      


His Ile Tyr Thr Tyr Cys Gly Ile Val Leu Val Ala Ile Asn Pro Tyr 
            100                 105                 110         


Glu Gln Leu Pro Ile Tyr Gly Gln Asp Val Ile Tyr Thr Tyr Ser Gly 
        115                 120                 125             


Gln Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu Glu 
    130                 135                 140                 


Ala Tyr Lys Gln Met Ala Arg Asp Glu Lys Asn Gln Ser Ile Ile Val 
145                 150                 155                 160 


Ser Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Lys Tyr Ala Met 
                165                 170                 175     


Arg Tyr Phe Ala Thr Val Gly Gly Ser Ala Ser Glu Thr Asn Ile Glu 
            180                 185                 190         


Glu Lys Val Leu Ala Ser Ser Pro Ile Met Glu Ala Ile Gly Asn Ala 
        195                 200                 205             


Lys Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile Gln 
    210                 215                 220                 


Ile Gly Phe Asp Lys Arg Tyr His Ile Ile Gly Ala Asn Met Arg Thr 
225                 230                 235                 240 


Tyr Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ala Asp Asp Glu Arg 
                245                 250                 255     


Asn Tyr His Ile Phe Tyr Gln Leu Cys Ala Ala Ala Gly Leu Pro Glu 
            260                 265                 270         


Phe Lys Glu Leu Ala Leu Thr Ser Ala Glu Asp Phe Phe Tyr Thr Ser 
        275                 280                 285             


Gln Gly Gly Asp Thr Ser Ile Glu Gly Val Asp Asp Ala Glu Asp Phe 
    290                 295                 300                 


Glu Lys Thr Arg Gln Ala Phe Thr Leu Leu Gly Val Lys Glu Ser His 
305                 310                 315                 320 


Gln Met Ser Ile Phe Lys Ile Ile Ala Ser Ile Leu His Leu Gly Ser 
                325                 330                 335     


Val Ala Ile Gln Ala Glu Arg Asp Gly Asp Ser Cys Ser Ile Ser Pro 
            340                 345                 350         


Gln Asp Val Tyr Leu Ser Asn Phe Cys Arg Leu Leu Gly Val Glu His 
        355                 360                 365             


Ser Gln Met Glu His Trp Leu Cys His Arg Lys Leu Val Thr Thr Ser 
    370                 375                 380                 


Glu Thr Tyr Val Lys Thr Met Ser Leu Gln Gln Val Ile Asn Ala Arg 
385                 390                 395                 400 


Asn Ala Leu Ala Lys His Ile Tyr Ala Gln Leu Phe Gly Trp Ile Val 
                405                 410                 415     


Glu His Ile Asn Lys Ala Leu His Thr Ser Leu Lys Gln His Ser Phe 
            420                 425                 430         


Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Glu Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln Gln 
    450                 455                 460                 


Phe Asn Ser His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys Glu 
465                 470                 475                 480 


Gln Ile Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Cys Ile 
                485                 490                 495     


Asp Leu Ile Glu Ala Lys Leu Gly Ile Leu Asp Leu Leu Asp Glu Glu 
            500                 505                 510         


Cys Lys Val Pro Lys Gly Thr Asp Gln Asn Trp Ala Gln Lys Leu Tyr 
        515                 520                 525             


Asp Arg His Ser Ser Ser Gln His Phe Gln Lys Pro Arg Met Ser Asn 
    530                 535                 540                 


Thr Ala Phe Ile Ile Val His Phe Ala Asp Lys Val Glu Tyr Leu Ser 
545                 550                 555                 560 


Asp Gly Phe Leu Glu Lys Asn Arg Asp Thr Val Tyr Glu Glu Gln Ile 
                565                 570                 575     


Asn Ile Leu Lys Ala Ser Lys Phe Pro Leu Val Ala Asp Leu Phe His 
            580                 585                 590         


Asp Asp Lys Asp Pro Val Pro Ala Thr Thr Pro Gly Lys Gly Ser Ser 
        595                 600                 605             


Ser Lys Ile Ser Val Arg Ser Ala Arg Pro Pro Met Lys Val Ser Asn 
    610                 615                 620                 


Lys Glu His Lys Lys Thr Val Gly His Gln Val Cys Thr Ser Leu Ser 
625                 630                 635                 640 


Thr Gln Gln Ile Val Lys Ile Leu Asn Leu Tyr Thr Pro Leu Asn Glu 
                645                 650                 655     


Phe Glu Glu Arg Val Thr Val Ala Phe Ile Arg Thr Ile Gln Ala Gln 
            660                 665                 670         


Leu Gln Glu Arg Asn Asp Pro Gln Gln Leu Leu Leu Asp Ala Lys His 
        675                 680                 685             


Met Phe Pro Val Leu Phe Pro Phe Asn Pro Ser Ser Leu Thr Met Asp 
    690                 695                 700                 


Ser Ile His Ile Pro Ala Cys Leu Asn Leu Glu Phe Leu Asn Glu Val 
705                 710                 715                 720 


<210>  3608
<211>  3955
<212>  DNA
<213>  Homosapiens

<400>  3608
ccgtagctgc gccgccgcgg cgggagtaaa ggtcgcgccg ccgggagcga gccggccgcg     60

gcgcctgcgg gaagccggcg gggcaggtcg gagaagagcg agaagatcga gaaactccag    120

gccagcccgg gaacatggcg ccaggcgggc cagccgcgga ctgagagccg cggggcagcc    180

aggagccggg gcccgagccc cgcccggccc gggccatgtc ggtgggcgag ctctacagcc    240

agtgcacaag ggtctggatc cctgaccctg atgaggtatg gcgctcagct gagttaacca    300

aggactacaa agaaggagac aagagcctac agctcagact ggaggatgaa acgattctgg    360

aatacccaat tgatgtacaa cgcaaccagc tgcccttctt acggaatcca gatatcttgg    420

tgggagaaaa tgacctgact gcccttagct atcttcatga gcctgcagtt ttgcataatt    480

tgaaggtccg tttcctggag tccaaccata tctacactta ctgtggtatc gtacttgttg    540

ccattaatcc ttatgaacag ttgccaatct atggacaaga tgtcatctat acctacagtg    600

gccaaaacat gggagacatg gacccccaca tctttgctgt ggcagaagaa gcctacaagc    660

agatggccag agatgagaag aatcagtcca tcatagtcag tggggagtct ggagccggga    720

agacggtatc agccaagtat gccatgcgct atttcgccac cgttggtggc tcggccagtg    780

aaaccaacat cgaagagaag gtgctggcat ccagtcccat catggaggcc attggaaatg    840

ccaagaccac ccgcaatgac aacagcagcc gttttggcaa gtacatccag attggctttg    900

acaaaaggta ccacatcatc ggggccaaca tgaggactta cctcttggag aagtccagag    960

tggtcttcca ggcagatgat gagaggaatt accacatctt ttaccagctc tgtgctgctg   1020

ccggtcttcc agaatttaaa gagcttgcac taacaagtgc agaggacttt ttctatacat   1080

cacagggagg agacacttcc atcgagggtg tggacgatgc tgaggacttt gagaagactc   1140

gacaagcctt cacactcctc ggagtgaaag agtcccatca gatgagcatt tttaagataa   1200

ttgcttctat cttgcacctt ggaagtgtgg cgattcaggc tgagcgtgat ggtgattcct   1260

gtagtatatc accccaggat gtatacctaa gcaacttctg ccgactgcta ggggtggagc   1320

acagtcagat ggagcactgg ctgtgtcatc gcaagctggt caccacctcg gagacctacg   1380

tcaagaccat gtccctgcag caggtgatca atgcgcgcaa cgccctggcg aagcacatct   1440

atgcccagtt gttcggctgg attgtggagc acatcaacaa ggccctgcac acctccctca   1500

agcagcactc cttcatcggg gtcctggaca tctatgggtt tgagacattt gaggtaaaca   1560

gctttgagca gttctgtatc aactatgcaa atgaaaagct ccagcagcag ttcaactcgc   1620

atgttttcaa actggagcaa gaagaataca tgaaggaaca gatcccttgg accctgattg   1680

atttttatga taaccaacct tgtatcgacc tcattgaagc caagctgggt atcttggacc   1740

tgttggatga agaatgtaag gtccccaaag gaactgacca gaactgggct cagaagctct   1800

atgaccggca ctccagcagc cagcacttcc agaagccccg catgtccaac acggccttca   1860

tcatcgtcca ctttgcagac aaggtggagt acctctctga tggttttctg gagaaaaaca   1920

gagacacggt gtatgaagag cagatcaata tcctgaaggc cagcaagttc ccactagtgg   1980

ctgacttgtt tcatgatgac aaggaccctg ttcctgccac cacccctggg aaggggtcat   2040

cttcgaagat cagcgtccgt tctgccagac cccccatgaa agtctccaac aaggagcaca   2100

agaaaaccgt tggccaccag ttccagacta gcttggccac ccaacagatt gtcaaaattt   2160

taaaccttta tactcccctg aatgaatttg aagaacgggt aacagtggcc tttatacgaa   2220

caatccaggc acaactacaa gagcggaatg accctcagca actgctatta gatgccaagc   2280

acatgtttcc tgttttgttt ccatttaatc catcttctct aaccatggac tcaatccaca   2340

tcccagcgtg tctcaatctg gaattcctca atgaagtctg aagatgcatg tttccagcat   2400

tagtttgatt cccaatgtga gcaagaagga agtatataca gtaaagtaaa ttcaaggatc   2460

tgttaaatct ggtaaaagta gatcaaatca gagattgaca gcctgtggag ggtgctgaac   2520

tatacagaat tagacacaac tatgtcatta ttttttgtac ctactgctca gaataaaaac   2580

acttgaaata tggaagattt taagtttgat ttcagtccaa cacatataca taatttatag   2640

acaccaagca gtccccatag acatataaaa ggtgtcaatt ctataaaacg aagctgccta   2700

gttttgatct ttgcatagaa ctagagaatg tccaaattaa aataccaaat atatataagt   2760

cacataaatt gccttcaaag ggctttaaca aataatggta ctaataacca tgataatggc   2820

atatactgac atttcccaaa gtttgcaaac cataggtgtg gttgagtttg tggtgagatg   2880

ttttaagaac aaaaatatgg ggatgagact tctgagaaat attcccaaaa tattttttaa   2940

tggctgatta tacacagaca gtggtgtaac tgacctccag accagacatt ttgagtactg   3000

gtttctgaag caaaattaga agtgccagtc ctcagtgtgc tcaaacgctt ttgtgttatc   3060

ttgatttaat ggaagagatt attaaaatgc tgctatccca aactccaagt gagaaagatg   3120

gaaaaatatt ttgtttctga tgctagtcca tacactttcc aagtcccaca aaactttcac   3180

aaaaatgtat ataagctaaa tattagaaac ggataacaaa cttgttttat ttatagatgt   3240

aaaaaccaaa caagtcaata tgaaagcttt taatctctta ataccattaa gcttccagta   3300

agagcatcac ataatgctct actgttccag aaaccaaata gtaaaacaaa ctaaagttcg   3360

cacatcagat catctgaaaa accttcaaaa ataatcagtt cagggatatt atacaaaagt   3420

ttgggttttt tttttttaag agaataaaat ggcttaggtc aactttccct tttcaggtta   3480

ttttcaacgt ttttcaaatt tagcacacaa aaaattgtaa atatctctcc cacaaaataa   3540

ggattttaaa aaagtaattc agtaatataa caggcttaga tgtttgctgc tcttagaatt   3600

ttttttaact tgtttttggt ttcttcaaaa gcaagcattc aattggaaac ccatattctt   3660

tccacacttt tttttactgt cttttctgta tttcttgata gcagtatgct gttcccataa   3720

gaaaaaaatg gtatttgcaa atcatggaag aacagcctct gtattacatt gagaaaataa   3780

gatttatcca tgaattggaa gtagaacagc ctgccttcac cctcttttac tcaaccaccc   3840

aacttaaaag gctcttggaa acacagcaca ctccacgcta ccttctgcac tgtgccctta   3900

gagcacagct tcctcagttg ttctctgcat ctcctggggc ttaggccagt cttag        3955


<210>  3609
<211>  721
<212>  PRT
<213>  Homosapiens

<400>  3609

Met Ser Val Gly Glu Leu Tyr Ser Gln Cys Thr Arg Val Trp Ile Pro 
1               5                   10                  15      


Asp Pro Asp Glu Val Trp Arg Ser Ala Glu Leu Thr Lys Asp Tyr Lys 
            20                  25                  30          


Glu Gly Asp Lys Ser Leu Gln Leu Arg Leu Glu Asp Glu Thr Ile Leu 
        35                  40                  45              


Glu Tyr Pro Ile Asp Val Gln Arg Asn Gln Leu Pro Phe Leu Arg Asn 
    50                  55                  60                  


Pro Asp Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu 
65                  70                  75                  80  


His Glu Pro Ala Val Leu His Asn Leu Lys Val Arg Phe Leu Glu Ser 
                85                  90                  95      


Asn His Ile Tyr Thr Tyr Cys Gly Ile Val Leu Val Ala Ile Asn Pro 
            100                 105                 110         


Tyr Glu Gln Leu Pro Ile Tyr Gly Gln Asp Val Ile Tyr Thr Tyr Ser 
        115                 120                 125             


Gly Gln Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu 
    130                 135                 140                 


Glu Ala Tyr Lys Gln Met Ala Arg Asp Glu Lys Asn Gln Ser Ile Ile 
145                 150                 155                 160 


Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Lys Tyr Ala 
                165                 170                 175     


Met Arg Tyr Phe Ala Thr Val Gly Gly Ser Ala Ser Glu Thr Asn Ile 
            180                 185                 190         


Glu Glu Lys Val Leu Ala Ser Ser Pro Ile Met Glu Ala Ile Gly Asn 
        195                 200                 205             


Ala Lys Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile 
    210                 215                 220                 


Gln Ile Gly Phe Asp Lys Arg Tyr His Ile Ile Gly Ala Asn Met Arg 
225                 230                 235                 240 


Thr Tyr Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ala Asp Asp Glu 
                245                 250                 255     


Arg Asn Tyr His Ile Phe Tyr Gln Leu Cys Ala Ala Ala Gly Leu Pro 
            260                 265                 270         


Glu Phe Lys Glu Leu Ala Leu Thr Ser Ala Glu Asp Phe Phe Tyr Thr 
        275                 280                 285             


Ser Gln Gly Gly Asp Thr Ser Ile Glu Gly Val Asp Asp Ala Glu Asp 
    290                 295                 300                 


Phe Glu Lys Thr Arg Gln Ala Phe Thr Leu Leu Gly Val Lys Glu Ser 
305                 310                 315                 320 


His Gln Met Ser Ile Phe Lys Ile Ile Ala Ser Ile Leu His Leu Gly 
                325                 330                 335     


Ser Val Ala Ile Gln Ala Glu Arg Asp Gly Asp Ser Cys Ser Ile Ser 
            340                 345                 350         


Pro Gln Asp Val Tyr Leu Ser Asn Phe Cys Arg Leu Leu Gly Val Glu 
        355                 360                 365             


His Ser Gln Met Glu His Trp Leu Cys His Arg Lys Leu Val Thr Thr 
    370                 375                 380                 


Ser Glu Thr Tyr Val Lys Thr Met Ser Leu Gln Gln Val Ile Asn Ala 
385                 390                 395                 400 


Arg Asn Ala Leu Ala Lys His Ile Tyr Ala Gln Leu Phe Gly Trp Ile 
                405                 410                 415     


Val Glu His Ile Asn Lys Ala Leu His Thr Ser Leu Lys Gln His Ser 
            420                 425                 430         


Phe Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Glu Val Asn 
        435                 440                 445             


Ser Phe Glu Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln 
    450                 455                 460                 


Gln Phe Asn Ser His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys 
465                 470                 475                 480 


Glu Gln Ile Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Cys 
                485                 490                 495     


Ile Asp Leu Ile Glu Ala Lys Leu Gly Ile Leu Asp Leu Leu Asp Glu 
            500                 505                 510         


Glu Cys Lys Val Pro Lys Gly Thr Asp Gln Asn Trp Ala Gln Lys Leu 
        515                 520                 525             


Tyr Asp Arg His Ser Ser Ser Gln His Phe Gln Lys Pro Arg Met Ser 
    530                 535                 540                 


Asn Thr Ala Phe Ile Ile Val His Phe Ala Asp Lys Val Glu Tyr Leu 
545                 550                 555                 560 


Ser Asp Gly Phe Leu Glu Lys Asn Arg Asp Thr Val Tyr Glu Glu Gln 
                565                 570                 575     


Ile Asn Ile Leu Lys Ala Ser Lys Phe Pro Leu Val Ala Asp Leu Phe 
            580                 585                 590         


His Asp Asp Lys Asp Pro Val Pro Ala Thr Thr Pro Gly Lys Gly Ser 
        595                 600                 605             


Ser Ser Lys Ile Ser Val Arg Ser Ala Arg Pro Pro Met Lys Val Ser 
    610                 615                 620                 


Asn Lys Glu His Lys Lys Thr Val Gly His Gln Phe Gln Thr Ser Leu 
625                 630                 635                 640 


Ala Thr Gln Gln Ile Val Lys Ile Leu Asn Leu Tyr Thr Pro Leu Asn 
                645                 650                 655     


Glu Phe Glu Glu Arg Val Thr Val Ala Phe Ile Arg Thr Ile Gln Ala 
            660                 665                 670         


Gln Leu Gln Glu Arg Asn Asp Pro Gln Gln Leu Leu Leu Asp Ala Lys 
        675                 680                 685             


His Met Phe Pro Val Leu Phe Pro Phe Asn Pro Ser Ser Leu Thr Met 
    690                 695                 700                 


Asp Ser Ile His Ile Pro Ala Cys Leu Asn Leu Glu Phe Leu Asn Glu 
705                 710                 715                 720 


Val 
    


<210>  3610
<211>  3080
<212>  DNA
<213>  Homosapiens

<400>  3610
gttccagagc aggtggcaac agcctgtgaa gagcagctct cctggcagcg tccctgactg     60

gcgcatttct gacggctgcc catgggccgc actggtcacc tccaactgca agcaggattt    120

tacccccacc atcccaggcc gggctgatgt ctgttctcac actgcttcct ctgcttccag    180

gaccttaaag aactggtaga aaagctggaa aagaatgaga ggaagctcaa aaagcaactg    240

aagatttaca tgaagaaagc ccaggaccta gaagctgccc aggcattggc ccagagtgag    300

aggaagcgcc atgagctcaa caggcaggtc acggtccagc ggaaagagaa ggatttccag    360

ggcatgctgg agtaccacaa agaggacgag gccctcctca tccggaacct ggtgacagac    420

ttgaagcccc agatgctgtc gggcacagtg ccctgtctcc ccgcctacat cctctacatg    480

tgcatccggc acgcggacta caccaacgac gatctcaagg tgcactccct gctgacctcc    540

accatcaacg gcattaagaa agtcctgaaa aagcacaatg atgactttga gatgacgtca    600

ttctggttat ccaacacctg ccgccttctt cactgtctga agcagtacag cggggatgag    660

ggcttcatga ctcagaacac tgcaaagcag aatgaacact gtcttaagaa ttttgacctc    720

accgaatacc gtcaggtgct gagtgacctt tccattcaga tctaccagca gctcattaaa    780

attgccgagg gcgtgttaca gccgatgata gtttctgcca tgttggaaaa tgagagcatt    840

cagggtctat ctggtgtgaa gcccaccggc taccggaagc gctcctccag catggcagat    900

ggggataact catactgcct ggaagctatc atccgccaga tgaatgcctt tcatacagtc    960

atgtgtgacc agggcttgga ccctgagatc atcctgcagg tattcaaaca gctcttctac   1020

atgatcaacg cagtgactct taacaacctg ctcttgcgga aggacgtctg ctcttggagc   1080

acaggcatgc aactcaggta caatataagt cagcttgagg agtggcttcg gggaagaaac   1140

cttcaccaga gtggagcagt tcagaccatg gaacctctga tccaagcagc ccagctcctg   1200

caattaaaga agaaaaccca ggaggacgca gaggctatct gctccctgtg tacctccctc   1260

agcacccagc agattgtcaa aattttaaac ctttatactc ccctgaatga atttgaagaa   1320

cgggtaacag tggcctttat acgaacaatc caggcacaac tacaagagcg gaatgaccct   1380

cagcaactgc tattagatgc caagcacatg tttcctgttt tgtttccatt taatccatct   1440

tctctaacca tggactcaat ccacatccca gcgtgtctca atctggaatt cctcaatgaa   1500

gtctgaagat gcatgtttcc agcattagtt tgattcccaa tgtgagcaag aaggaagtat   1560

atacagtaaa gtaaattcaa ggatctgtta aatctggtaa aagtagatca aatcagagat   1620

tgacagcctg tggagggtgc tgaactatac agaattagac acaactatgt cattattttt   1680

tgtacctact gctcagaata aaaacacttg aaatatggaa gattttaagt ttgatttcag   1740

tccaacacat atacataatt tatagacacc aagcagtccc catagacata taaaaggtgt   1800

caattctata aaacgaagct gcctagtttt gatctttgca tagaactaga gaatgtccaa   1860

attaaaatac caaatatata taagtcacat aaattgcctt caaagggctt taacaaataa   1920

tggtactaat aaccatgata atggcatata ctgacatttc ccaaagtttg caaaccatag   1980

gtgtggttga gtttgtggtg agatgtttta agaacaaaaa tatggggatg agacttctga   2040

gaaatattcc caaaatattt tttaatggct gattatacac agacagtggt gtaactgacc   2100

tccagaccag acattttgag tactggtttc tgaagcaaaa ttagaagtgc cagtcctcag   2160

tgtgctcaaa cgcttttgtg ttatcttgat ttaatggaag agattattaa aatgctgcta   2220

tcccaaactc caagtgagaa agatggaaaa atattttgtt tctgatgcta gtccatacac   2280

tttccaagtc ccacaaaact ttcacaaaaa tgtatataag ctaaatatta gaaacggata   2340

acaaacttgt tttatttata gatgtaaaaa ccaaacaagt caatatgaaa gcttttaatc   2400

tcttaatacc attaagcttc cagtaagagc atcacataat gctctactgt tccagaaacc   2460

aaatagtaaa acaaactaaa gttcgcacat cagatcatct gaaaaacctt caaaaataat   2520

cagttcaggg atattataca aaagtttggg tttttttttt ttaagagaat aaaatggctt   2580

aggtcaactt tcccttttca ggttattttc aacgtttttc aaatttagca cacaaaaaat   2640

tgtaaatatc tctcccacaa aataaggatt ttaaaaaagt aattcagtaa tataacaggc   2700

ttagatgttt gctgctctta gaattttttt taacttgttt ttggtttctt caaaagcaag   2760

cattcaattg gaaacccata ttctttccac actttttttt actgtctttt ctgtatttct   2820

tgatagcagt atgctgttcc cataagaaaa aaatggtatt tgcaaatcat ggaagaacag   2880

cctctgtatt acattgagaa aataagattt atccatgaat tggaagtaga acagcctgcc   2940

ttcaccctct tttactcaac cacccaactt aaaaggctct tggaaacaca gcacactcca   3000

cgctaccttc tgcactgtgc ccttagagca cagcttcctc agttgttctc tgcatctcct   3060

ggggcttagg ccagtcttag                                               3080


<210>  3611
<211>  418
<212>  PRT
<213>  Homosapiens

<400>  3611

Met Lys Lys Ala Gln Asp Leu Glu Ala Ala Gln Ala Leu Ala Gln Ser 
1               5                   10                  15      


Glu Arg Lys Arg His Glu Leu Asn Arg Gln Val Thr Val Gln Arg Lys 
            20                  25                  30          


Glu Lys Asp Phe Gln Gly Met Leu Glu Tyr His Lys Glu Asp Glu Ala 
        35                  40                  45              


Leu Leu Ile Arg Asn Leu Val Thr Asp Leu Lys Pro Gln Met Leu Ser 
    50                  55                  60                  


Gly Thr Val Pro Cys Leu Pro Ala Tyr Ile Leu Tyr Met Cys Ile Arg 
65                  70                  75                  80  


His Ala Asp Tyr Thr Asn Asp Asp Leu Lys Val His Ser Leu Leu Thr 
                85                  90                  95      


Ser Thr Ile Asn Gly Ile Lys Lys Val Leu Lys Lys His Asn Asp Asp 
            100                 105                 110         


Phe Glu Met Thr Ser Phe Trp Leu Ser Asn Thr Cys Arg Leu Leu His 
        115                 120                 125             


Cys Leu Lys Gln Tyr Ser Gly Asp Glu Gly Phe Met Thr Gln Asn Thr 
    130                 135                 140                 


Ala Lys Gln Asn Glu His Cys Leu Lys Asn Phe Asp Leu Thr Glu Tyr 
145                 150                 155                 160 


Arg Gln Val Leu Ser Asp Leu Ser Ile Gln Ile Tyr Gln Gln Leu Ile 
                165                 170                 175     


Lys Ile Ala Glu Gly Val Leu Gln Pro Met Ile Val Ser Ala Met Leu 
            180                 185                 190         


Glu Asn Glu Ser Ile Gln Gly Leu Ser Gly Val Lys Pro Thr Gly Tyr 
        195                 200                 205             


Arg Lys Arg Ser Ser Ser Met Ala Asp Gly Asp Asn Ser Tyr Cys Leu 
    210                 215                 220                 


Glu Ala Ile Ile Arg Gln Met Asn Ala Phe His Thr Val Met Cys Asp 
225                 230                 235                 240 


Gln Gly Leu Asp Pro Glu Ile Ile Leu Gln Val Phe Lys Gln Leu Phe 
                245                 250                 255     


Tyr Met Ile Asn Ala Val Thr Leu Asn Asn Leu Leu Leu Arg Lys Asp 
            260                 265                 270         


Val Cys Ser Trp Ser Thr Gly Met Gln Leu Arg Tyr Asn Ile Ser Gln 
        275                 280                 285             


Leu Glu Glu Trp Leu Arg Gly Arg Asn Leu His Gln Ser Gly Ala Val 
    290                 295                 300                 


Gln Thr Met Glu Pro Leu Ile Gln Ala Ala Gln Leu Leu Gln Leu Lys 
305                 310                 315                 320 


Lys Lys Thr Gln Glu Asp Ala Glu Ala Ile Cys Ser Leu Cys Thr Ser 
                325                 330                 335     


Leu Ser Thr Gln Gln Ile Val Lys Ile Leu Asn Leu Tyr Thr Pro Leu 
            340                 345                 350         


Asn Glu Phe Glu Glu Arg Val Thr Val Ala Phe Ile Arg Thr Ile Gln 
        355                 360                 365             


Ala Gln Leu Gln Glu Arg Asn Asp Pro Gln Gln Leu Leu Leu Asp Ala 
    370                 375                 380                 


Lys His Met Phe Pro Val Leu Phe Pro Phe Asn Pro Ser Ser Leu Thr 
385                 390                 395                 400 


Met Asp Ser Ile His Ile Pro Ala Cys Leu Asn Leu Glu Phe Leu Asn 
                405                 410                 415     


Glu Val 
        


<210>  3612
<211>  1965
<212>  DNA
<213>  Homosapiens

<400>  3612
agcgggttcc ccgtccgcgg cggccctgca ggcgaccccg cgtccccacc ggcgggagct     60

cggggaagag cgggcggcgg cgctgctgct ggcggcggcc ggctggatgc gagacccgcg    120

cagacccggc ggcggacggc ggctctcgac tccggagagc ggatcgcggg gcgcaggagc    180

ccgatcgcgc tggccatggc ctccaacttt aacgacatag tcaagcaggg ctacgtgaaa    240

atccgcagca ggaagcttgg gattttcaga cgatgctggt tggttttcaa gaaggcttct    300

agcaaaggac ccagaaggtt agaaaaattt ccagatgaaa aggcagctta tttcagaaac    360

tttcataagg taactgaact gcacaatatc aaaaatataa ccagactgcc ccgagagaca    420

aagaagcatg cggtggcaat catctttcac gatgaaacat cgaagacatt tgcctgtgag    480

tcagagctgg aggccgagga gtggtgcaag cacctctgca tggagtgtct ggggacaagg    540

ctcaatgaca tcagccttgg ggagcccgac cttctggccg caggagtgca gcgggaacag    600

aatgagagat tcaacgtgta tcttatgcct acgccaaacc tggatattta tggtgaatgc    660

acaatgcaga tcactcatga aaatatctat ctctgggata tccacaatgc caaggtcaaa    720

ctggtgatgt ggcctctcag ctcactgagg agatacggtc gggactcaac gtggtttacg    780

tttgagtcag gaagaatgtg tgacacagga gaaggactat tcacttttca aacaagggaa    840

ggagaaatga tctatcagaa ggttcattct gcgacactgg ccatagctga gcaacatgaa    900

agattaatgc tagaaatgga acagaaggcc cggcttcaga caagcttgac tgaaccaatg    960

acattatcca aatcaatatc tcttcctcgc agcgcgtact ggcatcacat cactcgtcag   1020

aacagcgttg gtgaaatcta cagtttgcaa ggtcatgggt ttggttcgtc aaagatgtct   1080

cgtgcacaga catttcccag ctacgcccca gaacagagtg aagaggccca gcagccgttg   1140

tcgcggtcca gcagctatgg attcagctac agctccagcc tcatccaatg acacacagag   1200

agccgctgtt gactagagag acagtctgtc ctggacccgt ctgtggggtc attaccctct   1260

gcctcctgga agaccaattg cagtacaaat tgaaatgggt cggctctagc cccagtccca   1320

ttggaaggtt aaaaactgga gttctgcttc cttgattcag tggctaagtc ctttatttat   1380

tgaatttctt tgggggaatc tatgttttac ataaatagaa tccaaatcgt atgaacagtt   1440

atttaaataa acaaaattct ttgggtctga cagtaacaga aacctcagca ctgggaaaag   1500

ctgcccacac tggggtatgc ctgggtgatg ggcacctctc actgacctca cagcgcagtc   1560

cgcccatctg agcacagggt ctgtccttag acataatggt gaccctccac aagctctgtg   1620

gcttttaaag ttctgacagg gataaataca gtaagctctg caaatgacat cgtagctgca   1680

tataaataaa cccagtgaca attaaaggaa catgaaattc agaacacact attaagcagg   1740

gccctgtagc tctactcgtg tgtgtgtgtg cgtgtgtgtg tgtgtgtgta gacaaatgga   1800

tattgctata tccatctata tataacaagt atatatcaaa catgtgctgg gggtgacagg   1860

atatgctcac ttaaattgtt gaaaaccata atttggtgca ttaaagttaa gattgttatg   1920

ttgaatagct atttttaaaa tagtgctgta aaaaaaaaaa aaaaa                   1965


<210>  3613
<211>  331
<212>  PRT
<213>  Homosapiens

<400>  3613

Met Ala Ser Asn Phe Asn Asp Ile Val Lys Gln Gly Tyr Val Lys Ile 
1               5                   10                  15      


Arg Ser Arg Lys Leu Gly Ile Phe Arg Arg Cys Trp Leu Val Phe Lys 
            20                  25                  30          


Lys Ala Ser Ser Lys Gly Pro Arg Arg Leu Glu Lys Phe Pro Asp Glu 
        35                  40                  45              


Lys Ala Ala Tyr Phe Arg Asn Phe His Lys Val Thr Glu Leu His Asn 
    50                  55                  60                  


Ile Lys Asn Ile Thr Arg Leu Pro Arg Glu Thr Lys Lys His Ala Val 
65                  70                  75                  80  


Ala Ile Ile Phe His Asp Glu Thr Ser Lys Thr Phe Ala Cys Glu Ser 
                85                  90                  95      


Glu Leu Glu Ala Glu Glu Trp Cys Lys His Leu Cys Met Glu Cys Leu 
            100                 105                 110         


Gly Thr Arg Leu Asn Asp Ile Ser Leu Gly Glu Pro Asp Leu Leu Ala 
        115                 120                 125             


Ala Gly Val Gln Arg Glu Gln Asn Glu Arg Phe Asn Val Tyr Leu Met 
    130                 135                 140                 


Pro Thr Pro Asn Leu Asp Ile Tyr Gly Glu Cys Thr Met Gln Ile Thr 
145                 150                 155                 160 


His Glu Asn Ile Tyr Leu Trp Asp Ile His Asn Ala Lys Val Lys Leu 
                165                 170                 175     


Val Met Trp Pro Leu Ser Ser Leu Arg Arg Tyr Gly Arg Asp Ser Thr 
            180                 185                 190         


Trp Phe Thr Phe Glu Ser Gly Arg Met Cys Asp Thr Gly Glu Gly Leu 
        195                 200                 205             


Phe Thr Phe Gln Thr Arg Glu Gly Glu Met Ile Tyr Gln Lys Val His 
    210                 215                 220                 


Ser Ala Thr Leu Ala Ile Ala Glu Gln His Glu Arg Leu Met Leu Glu 
225                 230                 235                 240 


Met Glu Gln Lys Ala Arg Leu Gln Thr Ser Leu Thr Glu Pro Met Thr 
                245                 250                 255     


Leu Ser Lys Ser Ile Ser Leu Pro Arg Ser Ala Tyr Trp His His Ile 
            260                 265                 270         


Thr Arg Gln Asn Ser Val Gly Glu Ile Tyr Ser Leu Gln Gly His Gly 
        275                 280                 285             


Phe Gly Ser Ser Lys Met Ser Arg Ala Gln Thr Phe Pro Ser Tyr Ala 
    290                 295                 300                 


Pro Glu Gln Ser Glu Glu Ala Gln Gln Pro Leu Ser Arg Ser Ser Ser 
305                 310                 315                 320 


Tyr Gly Phe Ser Tyr Ser Ser Ser Leu Ile Gln 
                325                 330     


<210>  3614
<211>  2750
<212>  DNA
<213>  Homosapiens

<400>  3614
ggagcagaca cacagacccg ggccggaggc ccctcttcta gccctgcggg aaccggacag     60

ttccccaact ggggactctg gaaccacagc tcctaaatca tcaaattctc aagctttttt    120

tttccctctc ttcgtcccag ccatcccagt cttcttcttc tttttttttt ttttaactta    180

ttgttttttt cgctcctgtc attatgaaag tggtcacgcc attcaatatt aagacttgga    240

gggaattggg gaaagaaaag aaagaatcta aaagaagaga agcgaccggt gcttttaagg    300

gtgtctaatt ttcaaaagag acgtctggga gtattttgct ctgggcgttt ggagcaactt    360

cgcggacagc ggagctcgcc cagcatggat gttccaggtt cacaggcgcc tttcttctga    420

gaacgaccct ggccttgaac gtcagagccg gggacgaagg cccccggagg ctgctgcgag    480

ctccgcgcgt tccttcgcgc ccttccgcgc cgctcgcgcc ggcgccggcc tccacccccg    540

cgcgccgcct cccaccagtc ccgatgcagg cgcccggccg ggggccactc gggctgcggc    600

tgatgatgcc cgggcgccgg ggggcgctgc gcgagcctgg cggctgcgga tcctgcctgg    660

gggtggcgct ggccctgctg ttgctgctac tgcccgcctg ctgccccgtg cgggcgcaga    720

acgacacgga gcccatcgtg ctggagggca agtgcctggt ggtgtgcgac tccagcccgt    780

cggcggacgg cgccgtcacc tcctccctag gcatctccgt gcgctccggc agcgccaagg    840

tggccttctc cgccacgcgg agcaccaacc acgagccgtc cgagatgagc aaccgcacca    900

tgaccatcta tttcgaccag gtattagtaa atattggcaa ccactttgat cttgcttcca    960

gtatatttgt agcaccgaga aaagggattt atagcttcag cttccacgtg gtcaaagtgt   1020

ataacagaca aaccatccag gtcagtttaa tgcagaatgg ctacccagtg atctcggcct   1080

ttgcaggaga ccaggatgtc accagagaag ctgctagcaa tggcgtgctg ctgctcatgg   1140

aaagggaaga caaagtgcat ctcaaacttg agagaggcaa cctcatgggg ggctggaaat   1200

actccacatt ctcgggcttc ttggtgtttc ctctataaac acagagcccc ctagatggtg   1260

ggggaatggc aaactggacc caggactccg ccctttaaaa caccctgaac ttactggaat   1320

tggacacctt gtttccaacc tccgtcagac tgttgcagta gaagaatgat ttcctttgaa   1380

acctccagta cttttgtttt tgttttttgg aatactgaca attcctcggg aacctggcct   1440

ctaattagtt ttagatgaca aggtcttaag gagaaatgaa attatcgatt tgagcaattt   1500

gtacctgtga ttgtaaagtc aatatcggat tttattgttg ggaccatgga cctcttttgt   1560

ttgtatgttg tattgtcgtc ccaacggaag gagagctcct gactccagga tgggctgcag   1620

gttgcagtca gggcttgaag taggagccca gcaaagaacc acctgctgga cagtccttga   1680

catgtgttct gtgtgtgtct gtatagcctt aagaaaaaga atggcttcac tttcattctg   1740

tattcttccc cccaccatgt ggctgggagg acttgggagg gggatgggga cattgggaac   1800

ctgtcaagaa gtgctttatc cagagaagca aattttgcac gattggactg caatttttgt   1860

tttgtattgt ttgtgttttt tcttgaaaag ctttactttt ctttccacac tcagctctcc   1920

ctcctcaacc ccacttttat ttttcttgct ggggttgagg agagaaaata tagaattcct   1980

ggataagacc aaacaaaaca aaacattaaa atacctgtat gttttgtttt agacgagacc   2040

aaactaaaca aaaagtatct gtttatcaaa gtaaaagtaa cacaatggac aattctgctt   2100

attctctcaa agagattcta agatgcacct ttagaactat taatagcaac ctgcattttt   2160

ttttaattta tacttcagaa tcctttaaga acctggtgtt cctgagtggt cctgaatcat   2220

ataagttggt aatggaagct gtaatgacca agtcccctaa acatactatg tctttgccac   2280

gtgtgctgtg acttctctgt gggtgattta atttatttgg atccacctct gagtgagcgc   2340

acagtgatca ggtgcttcaa agccaacaga ccagctcctc ttcctccgga tcctcttttg   2400

atctgcccag gaaagggatg cattgacact ctcctgcatg cacctggcga gaagccacct   2460

gaaagtcact gtggttaaag atattggtgg aggtacccca ggagcactgt tacaaatcct   2520

tcttgttttg gcatctcgta caacattatt aagacacagc tgagagttga tgggtgtgta   2580

atgcatatgc caaggaaatg tcactaatcc caaagcaatc aaaaaggaga cctcaaacca   2640

gatgttaatt tgttctttgt gtaacaatgt aaccaaaata ttgatgataa aagtcataat   2700

ttaagattca gaataaatgg gtttgatgtc tggcaaaaaa aaaaaaaaaa              2750


<210>  3615
<211>  224
<212>  PRT
<213>  Homosapiens

<400>  3615

Met Gln Ala Pro Gly Arg Gly Pro Leu Gly Leu Arg Leu Met Met Pro 
1               5                   10                  15      


Gly Arg Arg Gly Ala Leu Arg Glu Pro Gly Gly Cys Gly Ser Cys Leu 
            20                  25                  30          


Gly Val Ala Leu Ala Leu Leu Leu Leu Leu Leu Pro Ala Cys Cys Pro 
        35                  40                  45              


Val Arg Ala Gln Asn Asp Thr Glu Pro Ile Val Leu Glu Gly Lys Cys 
    50                  55                  60                  


Leu Val Val Cys Asp Ser Ser Pro Ser Ala Asp Gly Ala Val Thr Ser 
65                  70                  75                  80  


Ser Leu Gly Ile Ser Val Arg Ser Gly Ser Ala Lys Val Ala Phe Ser 
                85                  90                  95      


Ala Thr Arg Ser Thr Asn His Glu Pro Ser Glu Met Ser Asn Arg Thr 
            100                 105                 110         


Met Thr Ile Tyr Phe Asp Gln Val Leu Val Asn Ile Gly Asn His Phe 
        115                 120                 125             


Asp Leu Ala Ser Ser Ile Phe Val Ala Pro Arg Lys Gly Ile Tyr Ser 
    130                 135                 140                 


Phe Ser Phe His Val Val Lys Val Tyr Asn Arg Gln Thr Ile Gln Val 
145                 150                 155                 160 


Ser Leu Met Gln Asn Gly Tyr Pro Val Ile Ser Ala Phe Ala Gly Asp 
                165                 170                 175     


Gln Asp Val Thr Arg Glu Ala Ala Ser Asn Gly Val Leu Leu Leu Met 
            180                 185                 190         


Glu Arg Glu Asp Lys Val His Leu Lys Leu Glu Arg Gly Asn Leu Met 
        195                 200                 205             


Gly Gly Trp Lys Tyr Ser Thr Phe Ser Gly Phe Leu Val Phe Pro Leu 
    210                 215                 220                 


<210>  3616
<211>  3327
<212>  DNA
<213>  Homosapiens

<400>  3616
atgagccgcc gggcggcaga gaggatgctt cgagctgacg gggacttcct tgtgcgagac     60

agcgtcacca accccgggca gtatgtcctc accggcatgc acgccgggca gcccaagcac    120

ctgctgctcg tggaccccga gggcgtggta cggacgaagg acgtgctgtt tgagagcatc    180

agccacctga tcgaccacca cctgcagaac gggcagccca tcgtggccgc cgagatccga    240

ctgcgctgcc gccgccgccg ccgcccgcat cgaagctccg gccgcgtccc ccgcgccagc    300

cccgggagcc tgcgcgccga gacccctgcg tgtctgcgaa cagacctccg gcctcgggcc    360

atcaccccgg gcagacgctg cagcccctgt ccgggcctct tgcctgccgc ccccatgaga    420

aaaaccaaca tgtggttctt ggagcggctt cgggggtctg gggaaaacgg tgctgcccgg    480

ggcgtgggga gtgaggcggg ggacaaggcc tccaaggggc ccctgtacag caatgtgttg    540

acgcccgaca agatccccga ctttttcatc ccccccaagc tgccctcggg ccccgcggag    600

ggcgagggac aggccgcgct gggcccctcc acgtcggaac agaacctggc ctctgcggcc    660

ccccgccaga ccccacggag cccccggctg cctgccaagc tggcagccga gagcaagagc    720

ctgctgaagg cagccacccg gcacgtgatc cagatcgaga gtgccgagga ctggctgtcc    780

gaggaggcca ctgacgccga cccccaggcc cagggtgcca tgtccctgcc ctcggtgccc    840

aaggcccaga cgtcctacgg cttcgccatg ctggctgaga gcccccacac gaggcgcaag    900

gagtctctgt tccacagtga gcacggggct ctggcccagg tgggctcccc aggggccggg    960

cgccgccggg cagctgccaa ggccaacggg ggtgatgggg gccccaggga ggctggcggg   1020

gccctcatga gccccggccg ctacttcagt ggcggggaga gcgacacagg gtcctcggcc   1080

gagtcctccc ccttcgggtc ccctctgctg tcccgctccg tgtctctgct caaaggtttc   1140

gcccaggaca gccaggccaa ggtgagccag ctccggcact ccgtgggccg ccacggctcc   1200

ctgtctgcgg acgacagcac cccggacgcc agccccggga gccggcgccg cctgacccgc   1260

cgggcacccc cggaacctgg ccccgagtcg ggccaggcgc gtggggagca cacggtccac   1320

gtgggccctc ggggcagcgt gcggctgctg gccgagtacg aggccggcca ggcccgcctg   1380

cgggtgcacc tgctggccgc cgagggcctc tacgaccgcc tgtgcgacgc ccgcagcatc   1440

aactgctgcg tgggcctgtg cctggtgccg ggcaagctgc agaagcagcg cagcaccatc   1500

gtgaagaaca gccgccgccc cgtcttcaac gaggatttct tcttcgacgg cctggggccc   1560

gccagcgtcc ggaaactggc cctcaggatc aaggtggtga acaagggcag cagcctcaag   1620

cgggacacgc tgctcgggga gaaggagctg cccctgacct ccctgctccc cttcctgtag   1680

agcggggacc tgctcgctgt ccgctcgggt gcagagggca gaccccggtc tctcctccac   1740

accgggtgct ggcgggcggg tccgctggct tgggctgggg ctggccgggg aggggctcac   1800

actcaggctg ggctgggcgc tgatgctgta gctgacgcag ggtttcctgg gtcacccgat   1860

gctgactgga gtattatttt tcatgaatta atttctcctt tggaggagga ggaggaggag   1920

gagaggggcc tcgggggaag agaaggggcc acttcgcggg gcagagggtc cccctttgcc   1980

cctccacact gcctcgcgcc tttcacgcag agttctagaa ggaggttctc aggggttcag   2040

gaatccgtgc atgtggccag ggcggggccg tggacaggga ggtgacaagt cttggagccc   2100

acagtctcct tcactgcacg tgtgtcttcc tcccccacag cctgccgcca tccagttccc   2160

accccgcgga gagcagggcc tcgcggccac accaggccca ggctctgccc gggacgcccc   2220

ctcccagggg tcaggcttgg ctctgggaga ccccagcttc ccaggctccg gtggggagtg   2280

gggccaggcg agggtgccct gacgagggtg ggcgcggagg gagcagccgc tgccacagtc   2340

ggagcagagg aggtcttggc agaggtccgc ggggaggaga cggctctcct ggcctgtttt   2400

cctccaacac tgtcgccgct ggctttttgg gtacaggccc gtctggccat ttctgctgtg   2460

gcgccggagg gtcttgctca gagatgccca gagagcagcc ctatggccca tccgtcctcg   2520

ctgggggctg ccaccccgtc gcccttttgt ccagcgtctg cagctgggag cgacacgcag   2580

tgattgacgg ccgtggcttt gacgccacgt gtgtaaatag gctgtggcta cggtgggtgg   2640

gtcggagccc aggaggcagc tggggggacc tggctatggc ctttcctgct gttaggtggc   2700

tgcaaggctt ccattgtgtg gttatgtggg tccttgaatg attttgggga ggtttccagc   2760

tcagaatgat gcagaaatga taagactcaa agcaggggcc aggccaggcc agtgccttcg   2820

cctctcccgg ctgctggtgg gcacggagga accagggcac atctgtggta cccagggacg   2880

tcccttgtca gcccgtttgc cacacattgt tcctcttgtc caggggaggg tggaggagct   2940

gcttcccagg actggaggag cagctgggcc cctgctgcac gtccggtggg acacacctgt   3000

gagccctcca gagggagagt gcaggcccct tctgagcctg gtgttgcagg gctccgctct   3060

ctcccggaag ccagggcacc cagggcggag gctcctcagg ccggggaggc ggggagggtg   3120

ccctgcatgg agagagacgc cggcgctccc cgccttctct gatgctcacc cctcccaggc   3180

cctgttctcc ctggggtccc ccgtttagta gcccccctgc actctttgat atcttagtgt   3240

ctgaggttga ctgtgggtaa atctttaaga cactccccag ctgtgtttgt ttataaatgc   3300

tgtttatagt gcaataaagg tgtttcg                                       3327


<210>  3617
<211>  559
<212>  PRT
<213>  Homosapiens

<400>  3617

Met Ser Arg Arg Ala Ala Glu Arg Met Leu Arg Ala Asp Gly Asp Phe 
1               5                   10                  15      


Leu Val Arg Asp Ser Val Thr Asn Pro Gly Gln Tyr Val Leu Thr Gly 
            20                  25                  30          


Met His Ala Gly Gln Pro Lys His Leu Leu Leu Val Asp Pro Glu Gly 
        35                  40                  45              


Val Val Arg Thr Lys Asp Val Leu Phe Glu Ser Ile Ser His Leu Ile 
    50                  55                  60                  


Asp His His Leu Gln Asn Gly Gln Pro Ile Val Ala Ala Glu Ile Arg 
65                  70                  75                  80  


Leu Arg Cys Arg Arg Arg Arg Arg Pro His Arg Ser Ser Gly Arg Val 
                85                  90                  95      


Pro Arg Ala Ser Pro Gly Ser Leu Arg Ala Glu Thr Pro Ala Cys Leu 
            100                 105                 110         


Arg Thr Asp Leu Arg Pro Arg Ala Ile Thr Pro Gly Arg Arg Cys Ser 
        115                 120                 125             


Pro Cys Pro Gly Leu Leu Pro Ala Ala Pro Met Arg Lys Thr Asn Met 
    130                 135                 140                 


Trp Phe Leu Glu Arg Leu Arg Gly Ser Gly Glu Asn Gly Ala Ala Arg 
145                 150                 155                 160 


Gly Val Gly Ser Glu Ala Gly Asp Lys Ala Ser Lys Gly Pro Leu Tyr 
                165                 170                 175     


Ser Asn Val Leu Thr Pro Asp Lys Ile Pro Asp Phe Phe Ile Pro Pro 
            180                 185                 190         


Lys Leu Pro Ser Gly Pro Ala Glu Gly Glu Gly Gln Ala Ala Leu Gly 
        195                 200                 205             


Pro Ser Thr Ser Glu Gln Asn Leu Ala Ser Ala Ala Pro Arg Gln Thr 
    210                 215                 220                 


Pro Arg Ser Pro Arg Leu Pro Ala Lys Leu Ala Ala Glu Ser Lys Ser 
225                 230                 235                 240 


Leu Leu Lys Ala Ala Thr Arg His Val Ile Gln Ile Glu Ser Ala Glu 
                245                 250                 255     


Asp Trp Leu Ser Glu Glu Ala Thr Asp Ala Asp Pro Gln Ala Gln Gly 
            260                 265                 270         


Ala Met Ser Leu Pro Ser Val Pro Lys Ala Gln Thr Ser Tyr Gly Phe 
        275                 280                 285             


Ala Met Leu Ala Glu Ser Pro His Thr Arg Arg Lys Glu Ser Leu Phe 
    290                 295                 300                 


His Ser Glu His Gly Ala Leu Ala Gln Val Gly Ser Pro Gly Ala Gly 
305                 310                 315                 320 


Arg Arg Arg Ala Ala Ala Lys Ala Asn Gly Gly Asp Gly Gly Pro Arg 
                325                 330                 335     


Glu Ala Gly Gly Ala Leu Met Ser Pro Gly Arg Tyr Phe Ser Gly Gly 
            340                 345                 350         


Glu Ser Asp Thr Gly Ser Ser Ala Glu Ser Ser Pro Phe Gly Ser Pro 
        355                 360                 365             


Leu Leu Ser Arg Ser Val Ser Leu Leu Lys Gly Phe Ala Gln Asp Ser 
    370                 375                 380                 


Gln Ala Lys Val Ser Gln Leu Arg His Ser Val Gly Arg His Gly Ser 
385                 390                 395                 400 


Leu Ser Ala Asp Asp Ser Thr Pro Asp Ala Ser Pro Gly Ser Arg Arg 
                405                 410                 415     


Arg Leu Thr Arg Arg Ala Pro Pro Glu Pro Gly Pro Glu Ser Gly Gln 
            420                 425                 430         


Ala Arg Gly Glu His Thr Val His Val Gly Pro Arg Gly Ser Val Arg 
        435                 440                 445             


Leu Leu Ala Glu Tyr Glu Ala Gly Gln Ala Arg Leu Arg Val His Leu 
    450                 455                 460                 


Leu Ala Ala Glu Gly Leu Tyr Asp Arg Leu Cys Asp Ala Arg Ser Ile 
465                 470                 475                 480 


Asn Cys Cys Val Gly Leu Cys Leu Val Pro Gly Lys Leu Gln Lys Gln 
                485                 490                 495     


Arg Ser Thr Ile Val Lys Asn Ser Arg Arg Pro Val Phe Asn Glu Asp 
            500                 505                 510         


Phe Phe Phe Asp Gly Leu Gly Pro Ala Ser Val Arg Lys Leu Ala Leu 
        515                 520                 525             


Arg Ile Lys Val Val Asn Lys Gly Ser Ser Leu Lys Arg Asp Thr Leu 
    530                 535                 540                 


Leu Gly Glu Lys Glu Leu Pro Leu Thr Ser Leu Leu Pro Phe Leu 
545                 550                 555                 


<210>  3618
<211>  1083
<212>  DNA
<213>  Homosapiens

<400>  3618
atgatcagcc actcccgcac gccactaccg acccgcttct gcctccccgg gacccacttc     60

cgcctcccca agacccgctt ccgcctcccc aagacccgct tccgcctccc cggaacctac    120

ttccgcctcc ccaagaccct cttctgcctc cccgggaccg gcttccgcct ccccaggacc    180

cgcttccgcc tccccgggac ccacttccgc ctcccccggt acatgggctg catcgaggtt    240

ctccgctcta tgcgctccct ggactttaac acgcgcacgc aggtgaccag ggaagccatc    300

aaccggctcc atgaggccgt gcctggcgtc cggggatcct ggaagaaaaa ggcccccaac    360

aaggccctgg cgtccgtcct gggcaagagc aaccttcgct ttgccggcat gagcatctcc    420

atccacatct ccactgatgg cctcagcctc tccgtgcctg ccacgcgcca ggtcatcgcc    480

aaccaccaca tgccgtccat ctccttcgcg tcaggcggag acacggacat gacggattac    540

gtggcctacg tcgccaagga ccccatcaac cagagagcct gccacatcct ggagtgctgt    600

gagggcctgg cacagagcat catcagcacc gtgggccaag ctttcgagct gcgcttcaag    660

cagtacctgc acagcccgcc caaggtggcg ctgcccccag aaaggctggc agggccggag    720

gagtcggcct ggggggacga ggaggactct ttggagcaca attactacaa cagcatcccg    780

gggaaggagc cgccgctggg cgggctagtg gactccaggc tggccctgac acagccctgc    840

gccctcacgg ccctcgacca gacgggcggg ttaccacagg gagaccagag cagcatccgc    900

cctgcagcca gcagcacagc tccaccgggg gacggctacg tgcaggcgga cgcccggggc    960

cccccggacc acgaggagca cctgtatgtc aacacccagg gtctggacgc ccccgagccg   1020

gaggacagcc ccaaaaagga tctgtttgac atgccgaatg cggccgagca gtgtaatggg   1080

tga                                                                 1083


<210>  3619
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  3619

Met Ile Ser His Ser Arg Thr Pro Leu Pro Thr Arg Phe Cys Leu Pro 
1               5                   10                  15      


Gly Thr His Phe Arg Leu Pro Lys Thr Arg Phe Arg Leu Pro Lys Thr 
            20                  25                  30          


Arg Phe Arg Leu Pro Gly Thr Tyr Phe Arg Leu Pro Lys Thr Leu Phe 
        35                  40                  45              


Cys Leu Pro Gly Thr Gly Phe Arg Leu Pro Arg Thr Arg Phe Arg Leu 
    50                  55                  60                  


Pro Gly Thr His Phe Arg Leu Pro Arg Tyr Met Gly Cys Ile Glu Val 
65                  70                  75                  80  


Leu Arg Ser Met Arg Ser Leu Asp Phe Asn Thr Arg Thr Gln Val Thr 
                85                  90                  95      


Arg Glu Ala Ile Asn Arg Leu His Glu Ala Val Pro Gly Val Arg Gly 
            100                 105                 110         


Ser Trp Lys Lys Lys Ala Pro Asn Lys Ala Leu Ala Ser Val Leu Gly 
        115                 120                 125             


Lys Ser Asn Leu Arg Phe Ala Gly Met Ser Ile Ser Ile His Ile Ser 
    130                 135                 140                 


Thr Asp Gly Leu Ser Leu Ser Val Pro Ala Thr Arg Gln Val Ile Ala 
145                 150                 155                 160 


Asn His His Met Pro Ser Ile Ser Phe Ala Ser Gly Gly Asp Thr Asp 
                165                 170                 175     


Met Thr Asp Tyr Val Ala Tyr Val Ala Lys Asp Pro Ile Asn Gln Arg 
            180                 185                 190         


Ala Cys His Ile Leu Glu Cys Cys Glu Gly Leu Ala Gln Ser Ile Ile 
        195                 200                 205             


Ser Thr Val Gly Gln Ala Phe Glu Leu Arg Phe Lys Gln Tyr Leu His 
    210                 215                 220                 


Ser Pro Pro Lys Val Ala Leu Pro Pro Glu Arg Leu Ala Gly Pro Glu 
225                 230                 235                 240 


Glu Ser Ala Trp Gly Asp Glu Glu Asp Ser Leu Glu His Asn Tyr Tyr 
                245                 250                 255     


Asn Ser Ile Pro Gly Lys Glu Pro Pro Leu Gly Gly Leu Val Asp Ser 
            260                 265                 270         


Arg Leu Ala Leu Thr Gln Pro Cys Ala Leu Thr Ala Leu Asp Gln Thr 
        275                 280                 285             


Gly Gly Leu Pro Gln Gly Asp Gln Ser Ser Ile Arg Pro Ala Ala Ser 
    290                 295                 300                 


Ser Thr Ala Pro Pro Gly Asp Gly Tyr Val Gln Ala Asp Ala Arg Gly 
305                 310                 315                 320 


Pro Pro Asp His Glu Glu His Leu Tyr Val Asn Thr Gln Gly Leu Asp 
                325                 330                 335     


Ala Pro Glu Pro Glu Asp Ser Pro Lys Lys Asp Leu Phe Asp Met Pro 
            340                 345                 350         


Asn Ala Ala Glu Gln Cys Asn Gly 
        355                 360 


<210>  3620
<211>  1589
<212>  DNA
<213>  Homosapiens

<400>  3620
actcgatccc ggccccactt ccaggccagt gtccggccga ccagcctgcc ttgggccagg     60

gccccacgac tccctgctgc gggacaagag gccgtctgtg cggctgtggt cgtgggaggg    120

tgtggtgagg ccgtgaaggt ggggacggtg cctgggcctg tggccgccag agctgctgcg    180

gctcagaagg tagcaccagg ccccgtgggt gctgtggggg ccatcgcctg cccaccatgg    240

ggaccctcag ctgcgactcc accccacggc tggccacagc cccccttggc cggcgagtga    300

cggagggcca gattccggag accggcctga ggaagtcctg tgggacggcc accctggaga    360

acggctcggg gccaggcttg tatgtcctgc cgtccaccgt gggcttcatc aaccacgact    420

gcaccagggt ggccagtccc gcctactcgc tcgtccggag gcccagtgag gcaccacctc    480

aggacaccag cccgggcccc atctacttct tggaccccaa agtcacacgc tttggccgca    540

gctgcacccc tgcctactcc atgcagggcc gggccaagtc tcggggtccg gaggtgacgc    600

caggccctgg ggcctacagc ccagagaagg tgccccctgt gcgccatcgg acaccgccgg    660

ctttcaccct gggctgccgc ctccccctga agcccctgga cacctcagcc cctgccccta    720

atgcctacac catgccccct ctgtggggct cacagatctt caccaagccc agcagcccca    780

gctacacggt ggtgggccgc accccccccg cccgcccccc gcaggatcct gctgagatac    840

caggcccggg ccagtacgac agcccggacg caaacaccta ccgccagcgc ctgcctgcct    900

tcaccatgct ggggcggccc cgggccccgc gacccctgga ggagaccccc ggccctggcg    960

cccactgccc agagcaggtc accgtgaaca aagccagggc tccagcgttc tctatgggca   1020

tccgccactc gaaacgggcc agcaccatgg ccgccaccac gccctcccgg cctgcggggc   1080

acaggctgcc cggccgctgc tgctaggcca ggcctgtttc ccacacagtg aacgggggct   1140

ggcgggcctc tcctggggcc tggctttggc tggaggggct agaaggcgag aggggctggg   1200

aaaggagtct tccctcccct ttcctgaact gtccaggtcc ttctaggaca cctgatcctt   1260

ccagtccctg ggggctgtga cccatggccc tgtgcagggt acagggtgag tctccttcca   1320

gtgccccagt ttcttccagg tcacgccagg ccaggccagg ccaggtgggg aaagggacac   1380

cttccggccc tccccagtag ctggctggag atggagcttc tggtgtccca gaactcggcg   1440

tccagctcca ctagggccta gatccccatc acagcttggg ttagccccgg tcccagccca   1500

agctcaggct ggaggcagcc ccgaggcctg tgcctttccc actccacctt ctacagttgc   1560

ttagccaata aacctttcct gggctggag                                     1589


<210>  3621
<211>  289
<212>  PRT
<213>  Homosapiens

<400>  3621

Met Gly Thr Leu Ser Cys Asp Ser Thr Pro Arg Leu Ala Thr Ala Pro 
1               5                   10                  15      


Leu Gly Arg Arg Val Thr Glu Gly Gln Ile Pro Glu Thr Gly Leu Arg 
            20                  25                  30          


Lys Ser Cys Gly Thr Ala Thr Leu Glu Asn Gly Ser Gly Pro Gly Leu 
        35                  40                  45              


Tyr Val Leu Pro Ser Thr Val Gly Phe Ile Asn His Asp Cys Thr Arg 
    50                  55                  60                  


Val Ala Ser Pro Ala Tyr Ser Leu Val Arg Arg Pro Ser Glu Ala Pro 
65                  70                  75                  80  


Pro Gln Asp Thr Ser Pro Gly Pro Ile Tyr Phe Leu Asp Pro Lys Val 
                85                  90                  95      


Thr Arg Phe Gly Arg Ser Cys Thr Pro Ala Tyr Ser Met Gln Gly Arg 
            100                 105                 110         


Ala Lys Ser Arg Gly Pro Glu Val Thr Pro Gly Pro Gly Ala Tyr Ser 
        115                 120                 125             


Pro Glu Lys Val Pro Pro Val Arg His Arg Thr Pro Pro Ala Phe Thr 
    130                 135                 140                 


Leu Gly Cys Arg Leu Pro Leu Lys Pro Leu Asp Thr Ser Ala Pro Ala 
145                 150                 155                 160 


Pro Asn Ala Tyr Thr Met Pro Pro Leu Trp Gly Ser Gln Ile Phe Thr 
                165                 170                 175     


Lys Pro Ser Ser Pro Ser Tyr Thr Val Val Gly Arg Thr Pro Pro Ala 
            180                 185                 190         


Arg Pro Pro Gln Asp Pro Ala Glu Ile Pro Gly Pro Gly Gln Tyr Asp 
        195                 200                 205             


Ser Pro Asp Ala Asn Thr Tyr Arg Gln Arg Leu Pro Ala Phe Thr Met 
    210                 215                 220                 


Leu Gly Arg Pro Arg Ala Pro Arg Pro Leu Glu Glu Thr Pro Gly Pro 
225                 230                 235                 240 


Gly Ala His Cys Pro Glu Gln Val Thr Val Asn Lys Ala Arg Ala Pro 
                245                 250                 255     


Ala Phe Ser Met Gly Ile Arg His Ser Lys Arg Ala Ser Thr Met Ala 
            260                 265                 270         


Ala Thr Thr Pro Ser Arg Pro Ala Gly His Arg Leu Pro Gly Arg Cys 
        275                 280                 285             


Cys 
    


<210>  3622
<211>  1546
<212>  DNA
<213>  Homosapiens

<400>  3622
gggactgagc atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct     60

cggccagtcc ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt    120

ggccttgggc gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc    180

ggtgcagtgg cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag    240

cgtcctcacc gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc    300

ctgcgggggc cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca    360

gctgaccgtc tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca    420

caaagtcacg cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga    480

actggagggg gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg    540

ggacgaggac gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc    600

tgtcccgccc gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca    660

ccgccaggcc atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc    720

cccggagtct cccgacacca cctccccgga gtctcccgac accacctccc aggagcctcc    780

cgacaccacc tccccggagc ctcccgacaa gacctccccg gagcccgccc cccagcaggg    840

ctccacacac acccccagga gcccaggctc caccaggact cgccgccctg agatctccca    900

ggctgggccc acgcagggag aagtgatccc aacaggctcg tccaaacctg cgggtgacca    960

gctgcccgcg gctctgtgga ccagcagtgc ggtgctggga ctgctgctcc tggccttgcc   1020

cacctatcac ctctggaaac gctgccggca cctggctgag gacgacaccc acccaccagc   1080

ttctctgagg cttctgcccc aggtgtcggc ctgggctggg ttaaggggga ccggccaggt   1140

cgggatcagc ccctcctgag tggccagcct ttccccctgt gaaagcaaaa tagcttggac   1200

cccttcaagt tgagaactgg tcagggcaaa cctgcctccc attctactca aagtcatccc   1260

tctgttcaca gagatggatg catgttctga ttgcctcttt ggagaagctc atcagaaact   1320

caaaagaagg ccactgtttg tctcacctac ccatgacctg aagcccctcc ctgagtggtc   1380

cccacctttc tggacggaac cacgtacttt ttacatacat tgattcatgt ctcacgtctc   1440

cctaaaaatg cgtaagacca agctgtgccc tgaccaccct gggcccctgt cgtcaggacc   1500

tcctgaggct ttggcaaata aacctcctaa aatgataaaa aaaaaa                  1546


<210>  3623
<211>  382
<212>  PRT
<213>  Homosapiens

<400>  3623

Met Asp Phe Gly Leu Ala Leu Leu Leu Ala Gly Leu Leu Gly Leu Leu 
1               5                   10                  15      


Leu Gly Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu 
            20                  25                  30          


Pro Val Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg 
        35                  40                  45              


Leu Ala Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp 
    50                  55                  60                  


Thr Ser Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr 
65                  70                  75                  80  


Val Arg Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly 
                85                  90                  95      


Ser Cys Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr 
            100                 105                 110         


Ala Phe Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly 
        115                 120                 125             


Asp Pro Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro 
    130                 135                 140                 


Asn Ala Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly 
145                 150                 155                 160 


Ala Gln Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln 
                165                 170                 175     


Gly Asp Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro 
            180                 185                 190         


Pro Leu Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met 
        195                 200                 205             


Arg Leu Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu 
    210                 215                 220                 


His Ser Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Ser 
225                 230                 235                 240 


Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Gln Glu Pro 
                245                 250                 255     


Pro Asp Thr Thr Ser Pro Glu Pro Pro Asp Lys Thr Ser Pro Glu Pro 
            260                 265                 270         


Ala Pro Gln Gln Gly Ser Thr His Thr Pro Arg Ser Pro Gly Ser Thr 
        275                 280                 285             


Arg Thr Arg Arg Pro Glu Ile Ser Gln Ala Gly Pro Thr Gln Gly Glu 
    290                 295                 300                 


Val Ile Pro Thr Gly Ser Ser Lys Pro Ala Gly Asp Gln Leu Pro Ala 
305                 310                 315                 320 


Ala Leu Trp Thr Ser Ser Ala Val Leu Gly Leu Leu Leu Leu Ala Leu 
                325                 330                 335     


Pro Thr Tyr His Leu Trp Lys Arg Cys Arg His Leu Ala Glu Asp Asp 
            340                 345                 350         


Thr His Pro Pro Ala Ser Leu Arg Leu Leu Pro Gln Val Ser Ala Trp 
        355                 360                 365             


Ala Gly Leu Arg Gly Thr Gly Gln Val Gly Ile Ser Pro Ser 
    370                 375                 380         


<210>  3624
<211>  1285
<212>  DNA
<213>  Homosapiens

<400>  3624
gggactgagc atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct     60

cggccagtcc ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt    120

ggccttgggc gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc    180

ggtgcagtgg cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag    240

cgtcctcacc gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc    300

ctgcgggggc cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca    360

gctgaccgtc tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca    420

caaagtcacg cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga    480

actggagggg gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg    540

ggacgaggac gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc    600

tgtcccgccc gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca    660

ccgccaggcc atccccgcgt ccaaacctgc gggtgaccag ctgcccgcgg ctctgtggac    720

cagcagtgcg gtgctgggac tgctgctcct ggccttgccc acctatcacc tctggaaacg    780

ctgccggcac ctggctgagg acgacaccca cccaccagct tctctgaggc ttctgcccca    840

ggtgtcggcc tgggctgggt taagggggac cggccaggtc gggatcagcc cctcctgagt    900

ggccagcctt tccccctgtg aaagcaaaat agcttggacc ccttcaagtt gagaactggt    960

cagggcaaac ctgcctccca ttctactcaa agtcatccct ctgttcacag agatggatgc   1020

atgttctgat tgcctctttg gagaagctca tcagaaactc aaaagaaggc cactgtttgt   1080

ctcacctacc catgacctga agcccctccc tgagtggtcc ccacctttct ggacggaacc   1140

acgtactttt tacatacatt gattcatgtc tcacgtctcc ctaaaaatgc gtaagaccaa   1200

gctgtgccct gaccaccctg ggcccctgtc gtcaggacct cctgaggctt tggcaaataa   1260

acctcctaaa atgataaaaa aaaaa                                         1285


<210>  3625
<211>  295
<212>  PRT
<213>  Homosapiens

<400>  3625

Met Asp Phe Gly Leu Ala Leu Leu Leu Ala Gly Leu Leu Gly Leu Leu 
1               5                   10                  15      


Leu Gly Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu 
            20                  25                  30          


Pro Val Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg 
        35                  40                  45              


Leu Ala Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp 
    50                  55                  60                  


Thr Ser Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr 
65                  70                  75                  80  


Val Arg Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly 
                85                  90                  95      


Ser Cys Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr 
            100                 105                 110         


Ala Phe Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly 
        115                 120                 125             


Asp Pro Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro 
    130                 135                 140                 


Asn Ala Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly 
145                 150                 155                 160 


Ala Gln Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln 
                165                 170                 175     


Gly Asp Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro 
            180                 185                 190         


Pro Leu Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met 
        195                 200                 205             


Arg Leu Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Ala Ser 
    210                 215                 220                 


Lys Pro Ala Gly Asp Gln Leu Pro Ala Ala Leu Trp Thr Ser Ser Ala 
225                 230                 235                 240 


Val Leu Gly Leu Leu Leu Leu Ala Leu Pro Thr Tyr His Leu Trp Lys 
                245                 250                 255     


Arg Cys Arg His Leu Ala Glu Asp Asp Thr His Pro Pro Ala Ser Leu 
            260                 265                 270         


Arg Leu Leu Pro Gln Val Ser Ala Trp Ala Gly Leu Arg Gly Thr Gly 
        275                 280                 285             


Gln Val Gly Ile Ser Pro Ser 
    290                 295 


<210>  3626
<211>  1926
<212>  DNA
<213>  Homosapiens

<400>  3626
ctcagcgaag atggcggcag tggagaagcg gcggcaagcg gtaccaccgc cggccggttt     60

cacggacagc ggccgccagt cggtatcccg ggcggcgggg gcggccgaga gcgaggagga    120

cttcctgcgg caggtcggcg tgacggaaat gctacgtgcg gccctgctga aggtgctgga    180

ggcgcggccc gaggagccga tcgccttcct ggctcactac ttcgagaaca tgggcctgcg    240

ctcgcctgta aacggcggcg ccggggagcc cccgggccag ctcctgctgc agcagcagcg    300

cctgggccgc gcgctatggc accttcgcct ggcccaccac tcccagaggg ccgccttcaa    360

caacaacgtg agcgtggcct acgagtgcct gagcgccggc gggcgcagga agaggccggg    420

gctggacggg cgcacctaca gcgagctgct caggcgcatc tgccgggacg gccaagcccc    480

cgaggaggtg gtggcgccgc tgctgcgcaa ggtgcagtgc cgtgaccacg aggcggtgcc    540

gctgagcgtc ttccgcgcgg gcacactcac ctgcttcgtg ctgctggagt tcgtggcgcg    600

cgccggcgcg ctcttccagc tgctggagga ctcggccgcc gccgtggccg accgccgcgt    660

gggccaggcc gtgctggaca ccctggaggg cgcgctgcag gccagcgacg ccgccgcgcc    720

cgcgcgcttc ctggaggccg gctcgcgctt ggcgcccatg acccgcgagg agtttctgga    780

gagggccgcc gcgctcttca tcgcgaaggt caagccggtg ggctgaggcc cgtgggccgc    840

gcggatccgg gatctgcgct ggggggtccc cgcgtgcggg gcgcgcggag ccttcccttc    900

gccctggtga ggccctgcca taaccaggcg cccagccctg cggaggaggc cggggctccc    960

aggaagcgga cgcccggtcc ccacacagcg ccgcggccgc ccctccaccc ccgcgggagc   1020

ccctgcccca cgctaataaa atgtgttgcg aggctgacgc tggtgtgtat gcgagcgccc   1080

gcctcccagc cccggtgccc gcagaagacg cttttcccca gcaggtcacc cacggccccg   1140

gaaccgcggc ggctggaggc tggattcgag gccggaaacg ccgggacccc tggacccggc   1200

ctggtgggag cagcggaggg ggacgcccca cggggccctg cggagcctga agccggagag   1260

caggcggctc ttctggaacg cagggcccgg gccctccagc cccgcccggc ccaggtatcc   1320

tccctgagcc tcagtctccc cagatgtcaa atgaagaggc cagctgggca gatggtagtg   1380

acattggtga gacaacagcc ctaacacttc ccaggaactg aagtgcctca tgtgattgat   1440

tcccaggccc aggcagcgga ggttacaccc tcagcaaggg ctcagctggg atctgcgccc   1500

ggcctgctcc agaacgcaca gggcctccca ctcgccaccg gtggggaggg tcgtccggta   1560

tcccccagtg cccaccacca ccaaccagaa tcacttctca gactgcaaga gcgaatccag   1620

ccgggcgtgg tggctcacgc ctgtgacccc agcactttgg gaggctgggg cggcggatca   1680

cttgaggtca ggagttcagg atcagcctgg ccaacgtggt gaaaccctgt ctctactaaa   1740

aatacgaaaa aaaaaaaaag ctgggctgtg gtggcaggcg cctgtgatcc cagctactcg   1800

ggaggctggg gcaggagaat aacttgaacc cgggaggcag aggtggcagt gagccgagat   1860

tgagccactg cactccaatc tgtgcgacag agtgagaccc tgtctcaaaa acaaaacaac   1920

aacaac                                                              1926


<210>  3627
<211>  271
<212>  PRT
<213>  Homosapiens

<400>  3627

Met Ala Ala Val Glu Lys Arg Arg Gln Ala Val Pro Pro Pro Ala Gly 
1               5                   10                  15      


Phe Thr Asp Ser Gly Arg Gln Ser Val Ser Arg Ala Ala Gly Ala Ala 
            20                  25                  30          


Glu Ser Glu Glu Asp Phe Leu Arg Gln Val Gly Val Thr Glu Met Leu 
        35                  40                  45              


Arg Ala Ala Leu Leu Lys Val Leu Glu Ala Arg Pro Glu Glu Pro Ile 
    50                  55                  60                  


Ala Phe Leu Ala His Tyr Phe Glu Asn Met Gly Leu Arg Ser Pro Val 
65                  70                  75                  80  


Asn Gly Gly Ala Gly Glu Pro Pro Gly Gln Leu Leu Leu Gln Gln Gln 
                85                  90                  95      


Arg Leu Gly Arg Ala Leu Trp His Leu Arg Leu Ala His His Ser Gln 
            100                 105                 110         


Arg Ala Ala Phe Asn Asn Asn Val Ser Val Ala Tyr Glu Cys Leu Ser 
        115                 120                 125             


Ala Gly Gly Arg Arg Lys Arg Pro Gly Leu Asp Gly Arg Thr Tyr Ser 
    130                 135                 140                 


Glu Leu Leu Arg Arg Ile Cys Arg Asp Gly Gln Ala Pro Glu Glu Val 
145                 150                 155                 160 


Val Ala Pro Leu Leu Arg Lys Val Gln Cys Arg Asp His Glu Ala Val 
                165                 170                 175     


Pro Leu Ser Val Phe Arg Ala Gly Thr Leu Thr Cys Phe Val Leu Leu 
            180                 185                 190         


Glu Phe Val Ala Arg Ala Gly Ala Leu Phe Gln Leu Leu Glu Asp Ser 
        195                 200                 205             


Ala Ala Ala Val Ala Asp Arg Arg Val Gly Gln Ala Val Leu Asp Thr 
    210                 215                 220                 


Leu Glu Gly Ala Leu Gln Ala Ser Asp Ala Ala Ala Pro Ala Arg Phe 
225                 230                 235                 240 


Leu Glu Ala Gly Ser Arg Leu Ala Pro Met Thr Arg Glu Glu Phe Leu 
                245                 250                 255     


Glu Arg Ala Ala Ala Leu Phe Ile Ala Lys Val Lys Pro Val Gly 
            260                 265                 270     


<210>  3628
<211>  1462
<212>  DNA
<213>  Homosapiens

<400>  3628
ggcaagcgcc ggtggggcgg cggcgccaga gctgctggag cgctcggggt ccccgggcgg     60

cggcggcggc gcagaggagg aggcaggcgg cggccccggt ggctcccccc cggacggtgc    120

gcggcccggc ccgtctcgcg aactcgcggt ggtcgcgcgg ccccgcgctg ctccgacccc    180

gggcccctcc gccgccgcca tggctcggcc gctagtgccc agctcgcaga aggcgctgct    240

gctggagctc aaggggctgc aggaagagcc ggtcgaggga ttccgcgtga cactggtgga    300

cgagggcgat ctatacaact gggaggtggc catcttcggg ccccccaaca cctactacga    360

gggcggctac ttcaaggcgc gcctcaagtt ccccatcgac tacccatact ctccaccagc    420

ctttcggttc ctgaccaaga tgtggcaccc taacatctac gagacggggg acgtgtgtat    480

ctccatcctc cacccgccgg tggacgaccc ccagagcggg gagctgccct cagagaggtg    540

gaaccccacg cagaacgtca ggaccattct cctgagtgtg atctccctcc tgaacgagcc    600

caacaccttc tcgcccgcaa acgtggacgc ctccgtgatg tacaggaagt ggaaagagag    660

caaggggaag gatcgggagt acacagacat catccggaag caggtcctgg ggaccaaggt    720

ggacgcggag cgtgacggcg tgaaggtgcc caccacgctg gccgagtact gcgtgaagac    780

caaggcgccg gcgcccgacg agggctcaga cctcttctac gacgactact acgaggacgg    840

cgaggtggag gaggaggccg acagctgctt cggggacgat gaggatgact ctggcacgga    900

ggagtcctga caccaccaga ataaacttgc cgagtttacc tcactagggc cggacccgtg    960

gctccttaga cgacagacta cctcacggag gttttgtgct ggtccccgtc tcctctggtt   1020

gtttcgtttt ggctttttct ccctccccat gtctgttctg ggttttcacg tgcttcagag   1080

aagaggggct gccccaccgc cactcacgtc actcggggct cggtggacgg gcccagggtg   1140

ggagcggccg gcccacctgt cccctcggga ggggagctga gcccgacttc taccggggtc   1200

ccccagcttc cggactggcc gcaccccgga ggagccacgg gggcgctgct gggaacgtgg   1260

gcggggggcc gtttcctgac actaccagcc tgggaggccc aggtgtagcg gtccgagggg   1320

cccggtcctg cctgtcagct ccaggtcctg gagccacgtc cagcacagag tggacggatt   1380

caccgtggcc gactcttttc cctgctttgg tttgtttgaa atctaaataa aactacttta   1440

tgagaaaaaa aaaaaaaaaa aa                                            1462


<210>  3629
<211>  236
<212>  PRT
<213>  Homosapiens

<400>  3629

Met Ala Arg Pro Leu Val Pro Ser Ser Gln Lys Ala Leu Leu Leu Glu 
1               5                   10                  15      


Leu Lys Gly Leu Gln Glu Glu Pro Val Glu Gly Phe Arg Val Thr Leu 
            20                  25                  30          


Val Asp Glu Gly Asp Leu Tyr Asn Trp Glu Val Ala Ile Phe Gly Pro 
        35                  40                  45              


Pro Asn Thr Tyr Tyr Glu Gly Gly Tyr Phe Lys Ala Arg Leu Lys Phe 
    50                  55                  60                  


Pro Ile Asp Tyr Pro Tyr Ser Pro Pro Ala Phe Arg Phe Leu Thr Lys 
65                  70                  75                  80  


Met Trp His Pro Asn Ile Tyr Glu Thr Gly Asp Val Cys Ile Ser Ile 
                85                  90                  95      


Leu His Pro Pro Val Asp Asp Pro Gln Ser Gly Glu Leu Pro Ser Glu 
            100                 105                 110         


Arg Trp Asn Pro Thr Gln Asn Val Arg Thr Ile Leu Leu Ser Val Ile 
        115                 120                 125             


Ser Leu Leu Asn Glu Pro Asn Thr Phe Ser Pro Ala Asn Val Asp Ala 
    130                 135                 140                 


Ser Val Met Tyr Arg Lys Trp Lys Glu Ser Lys Gly Lys Asp Arg Glu 
145                 150                 155                 160 


Tyr Thr Asp Ile Ile Arg Lys Gln Val Leu Gly Thr Lys Val Asp Ala 
                165                 170                 175     


Glu Arg Asp Gly Val Lys Val Pro Thr Thr Leu Ala Glu Tyr Cys Val 
            180                 185                 190         


Lys Thr Lys Ala Pro Ala Pro Asp Glu Gly Ser Asp Leu Phe Tyr Asp 
        195                 200                 205             


Asp Tyr Tyr Glu Asp Gly Glu Val Glu Glu Glu Ala Asp Ser Cys Phe 
    210                 215                 220                 


Gly Asp Asp Glu Asp Asp Ser Gly Thr Glu Glu Ser 
225                 230                 235     


<210>  3630
<211>  947
<212>  DNA
<213>  Homosapiens

<400>  3630
ggctcggggc cggggccagc acccacactg ggtctccaca gcggcatgga ggcctgcgtg     60

tcttcactgc tggtgctggc cctgggggcc ctgtcagtag gcagctcctt tgggacccag    120

atcatcgggg gccgggaggt gatcccccac tcgcgcccgt acatggcctc actgcagaga    180

aatggctccc acctgtgcgg gggtgtcctg gtgcacccaa agtgggtgct gacggctgcc    240

cactgcctgg cccagcggat ggcccagctg aggctggtgc tggggctcca caccctggac    300

agccccggtc tcaccttcca catcaaggca gccatccagc accctcgcta caagcccgtc    360

cctgccctgg agaacgacct cgcgctgctt cagctggacg ggaaagtgaa gcccagccgg    420

accatccggc cgttggccct gcccagtaag cgccaggtgg tggcagcagg gactcggtgc    480

agcatggccg gctgggggct gacccaccag ggcgggcgcc tgtcccgggt gctgcgggag    540

ctggacctcc aagtgctgga cacccgcatg tgtaacaaca gccgcttctg gaacggcagc    600

ctctccccca gcatggtctg cctggcggcc gactccaagg accaggctcc ctgcaagggt    660

gactcgggcg ggcccctggt gtgtggcaaa ggccgggtgt tggccggagt cctgtccttc    720

agctccaggg tctgcactga catcttcaag cctcccgtgg ccaccgctgt ggcgccttac    780

gtgtcctgga tcaggaaggt caccggccga tcggcctgat gccctggggt gatggggacc    840

ccctcgctgt ctccacagga cccttcccct ccaggggtgc agtggggtgg gtgaggacgg    900

gtgggaggga cagggaggga ccaataaatc ataatgaaga aacgctc                  947


<210>  3631
<211>  257
<212>  PRT
<213>  Homosapiens

<400>  3631

Met Glu Ala Cys Val Ser Ser Leu Leu Val Leu Ala Leu Gly Ala Leu 
1               5                   10                  15      


Ser Val Gly Ser Ser Phe Gly Thr Gln Ile Ile Gly Gly Arg Glu Val 
            20                  25                  30          


Ile Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Arg Asn Gly Ser 
        35                  40                  45              


His Leu Cys Gly Gly Val Leu Val His Pro Lys Trp Val Leu Thr Ala 
    50                  55                  60                  


Ala His Cys Leu Ala Gln Arg Met Ala Gln Leu Arg Leu Val Leu Gly 
65                  70                  75                  80  


Leu His Thr Leu Asp Ser Pro Gly Leu Thr Phe His Ile Lys Ala Ala 
                85                  90                  95      


Ile Gln His Pro Arg Tyr Lys Pro Val Pro Ala Leu Glu Asn Asp Leu 
            100                 105                 110         


Ala Leu Leu Gln Leu Asp Gly Lys Val Lys Pro Ser Arg Thr Ile Arg 
        115                 120                 125             


Pro Leu Ala Leu Pro Ser Lys Arg Gln Val Val Ala Ala Gly Thr Arg 
    130                 135                 140                 


Cys Ser Met Ala Gly Trp Gly Leu Thr His Gln Gly Gly Arg Leu Ser 
145                 150                 155                 160 


Arg Val Leu Arg Glu Leu Asp Leu Gln Val Leu Asp Thr Arg Met Cys 
                165                 170                 175     


Asn Asn Ser Arg Phe Trp Asn Gly Ser Leu Ser Pro Ser Met Val Cys 
            180                 185                 190         


Leu Ala Ala Asp Ser Lys Asp Gln Ala Pro Cys Lys Gly Asp Ser Gly 
        195                 200                 205             


Gly Pro Leu Val Cys Gly Lys Gly Arg Val Leu Ala Gly Val Leu Ser 
    210                 215                 220                 


Phe Ser Ser Arg Val Cys Thr Asp Ile Phe Lys Pro Pro Val Ala Thr 
225                 230                 235                 240 


Ala Val Ala Pro Tyr Val Ser Trp Ile Arg Lys Val Thr Gly Arg Ser 
                245                 250                 255     


Ala 
    


<210>  3632
<211>  2024
<212>  DNA
<213>  Homosapiens

<400>  3632
gtgcgcgcgc ccggtccgcg cctccgccgc tttttatagc ggccgcgggc ggcggcggca     60

gcggttggag gttgtaggac cggcgaggaa taggaatcat ggcggctgcg ctgttcgtgc    120

tgctgggatt cgcgctgctg ggcacccacg gagcctccgg ggctgccggc ttcgtccagg    180

cgccgctgtc ccagcagagg tgggtggggg gcagtgtgga gctgcactgc gaggccgtgg    240

gcagcccggt gcccgagatc cagtggtggt ttgaagggca gggtcccaac gacacctgct    300

cccagctctg ggacggcgcc cggctggacc gcgtccacat ccacgccacc taccaccagc    360

acgcggccag caccatctcc atcgacacgc tcgtggagga ggacacgggc acttacgagt    420

gccgggccag caacgacccg gatcgcaacc acctgacccg ggcgcccagg gtcaagtggg    480

tccgcgccca ggcagtcgtg ctagtcctgg aacccggcac agtcttcact accgtagaag    540

accttggctc caagatactc ctcacctgct ccttgaatga cagcgccaca gaggtcacag    600

ggcaccgctg gctgaagggg ggcgtggtgc tgaaggagga cgcgctgccc ggccagaaaa    660

cggagttcaa ggtggactcc gacgaccagt ggggagagta ctcctgcgtc ttcctccccg    720

agcccatggg cacggccaac atccagctcc acgggcctcc cagagtgaag gctgtgaagt    780

cgtcagaaca catcaacgag ggggagacgg ccatgctggt ctgcaagtca gagtccgtgc    840

cacctgtcac tgactgggcc tggtacaaga tcactgactc tgaggacaag gccctcatga    900

acggctccga gagcaggttc ttcgtgagtt cctcgcaggg ccggtcagag ctacacattg    960

agaacctgaa catggaggcc gaccccggcc agtaccggtg caacggcacc agctccaagg   1020

gctccgacca ggccatcatc acgctccgcg tgcgcagcca cctggccgcc ctctggccct   1080

tcctgggcat cgtggctgag gtgctggtgc tggtcaccat catcttcatc tacgagaagc   1140

gccggaagcc cgaggacgtc ctggatgatg acgacgccgg ctctgcaccc ctgaagagca   1200

gcgggcagca ccagaatgac aaaggcaaga acgtccgcca gaggaactct tcctgaggca   1260

ggtggcccga ggacgctccc tgctccacgt ctgcgccgcc gccggagtcc actcccagtg   1320

cttgcaagat tccaagttct cacctcttaa agaaaaccca ccccgtagat tcccatcata   1380

cacttccttc ttttttaaaa aagttgggtt ttctccattc aggattctgt tccttaggtt   1440

tttttccttc tgaagtgttt cacgagagcc cgggagctgc tgccctgcgg ccccgtctgt   1500

ggctttcagc ctctgggtct gagtcatggc cgggtgggcg gcacagcctt ctccactggc   1560

cggagtcagt gccaggtcct tgccctttgt ggaaagtcac aggtcacacg aggggccccg   1620

tgtcctgcct gtctgaagcc aatgctgtct ggttgcgcca tttttgtgct tttatgttta   1680

attttatgag ggccacgggt ctgtgttcga ctcagcctca gggacgactc tgacctcttg   1740

gccacagagg actcacttgc ccacaccgag ggcgaccccg tcacagcctc aagtcactcc   1800

caagccccct ccttgtctgt gcatccgggg gcagctctgg agggggtttg ctggggaact   1860

ggcgccatcg ccgggactcc agaaccgcag aagcctcccc agctcacccc tggaggacgg   1920

ccggctctct atagcaccag ggctcacgtg ggaacccccc tcccacccac cgccacaata   1980

aagatcgccc ccacctccac cctcaaaaaa aaaaaaaaaa aaaa                    2024


<210>  3633
<211>  385
<212>  PRT
<213>  Homosapiens

<400>  3633

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 
            20                  25                  30          


Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 
    50                  55                  60                  


Asp Thr Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Thr Tyr His Gln His Ala Ala Ser Thr Ile Ser Ile Asp 
                85                  90                  95      


Thr Leu Val Glu Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Thr Arg Ala Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Thr Val Phe Thr 
    130                 135                 140                 


Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn 
145                 150                 155                 160 


Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val 
                165                 170                 175     


Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val 
            180                 185                 190         


Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 
        195                 200                 205             


Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 
    210                 215                 220                 


Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu 
225                 230                 235                 240 


Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr 
                245                 250                 255     


Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 
            260                 265                 270         


Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 
        275                 280                 285             


Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr 
    290                 295                 300                 


Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser 
305                 310                 315                 320 


His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 
                325                 330                 335     


Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 
            340                 345                 350         


Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 
        355                 360                 365             


Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 
    370                 375                 380                 


Ser 
385 


<210>  3634
<211>  1676
<212>  DNA
<213>  Homosapiens

<400>  3634
gtgcgcgcgc ccggtccgcg cctccgccgc tttttatagc ggccgcgggc ggcggcggca     60

gcggttggag gttgtaggac cggcgaggaa taggaatcat ggcggctgcg ctgttcgtgc    120

tgctgggatt cgcgctgctg ggcacccacg gagcctccgg ggctgccggc acagtcttca    180

ctaccgtaga agaccttggc tccaagatac tcctcacctg ctccttgaat gacagcgcca    240

cagaggtcac agggcaccgc tggctgaagg ggggcgtggt gctgaaggag gacgcgctgc    300

ccggccagaa aacggagttc aaggtggact ccgacgacca gtggggagag tactcctgcg    360

tcttcctccc cgagcccatg ggcacggcca acatccagct ccacgggcct cccagagtga    420

aggctgtgaa gtcgtcagaa cacatcaacg agggggagac ggccatgctg gtctgcaagt    480

cagagtccgt gccacctgtc actgactggg cctggtacaa gatcactgac tctgaggaca    540

aggccctcat gaacggctcc gagagcaggt tcttcgtgag ttcctcgcag ggccggtcag    600

agctacacat tgagaacctg aacatggagg ccgaccccgg ccagtaccgg tgcaacggca    660

ccagctccaa gggctccgac caggccatca tcacgctccg cgtgcgcagc cacctggccg    720

ccctctggcc cttcctgggc atcgtggctg aggtgctggt gctggtcacc atcatcttca    780

tctacgagaa gcgccggaag cccgaggacg tcctggatga tgacgacgcc ggctctgcac    840

ccctgaagag cagcgggcag caccagaatg acaaaggcaa gaacgtccgc cagaggaact    900

cttcctgagg caggtggccc gaggacgctc cctgctccac gtctgcgccg ccgccggagt    960

ccactcccag tgcttgcaag attccaagtt ctcacctctt aaagaaaacc caccccgtag   1020

attcccatca tacacttcct tcttttttaa aaaagttggg ttttctccat tcaggattct   1080

gttccttagg tttttttcct tctgaagtgt ttcacgagag cccgggagct gctgccctgc   1140

ggccccgtct gtggctttca gcctctgggt ctgagtcatg gccgggtggg cggcacagcc   1200

ttctccactg gccggagtca gtgccaggtc cttgcccttt gtggaaagtc acaggtcaca   1260

cgaggggccc cgtgtcctgc ctgtctgaag ccaatgctgt ctggttgcgc catttttgtg   1320

cttttatgtt taattttatg agggccacgg gtctgtgttc gactcagcct cagggacgac   1380

tctgacctct tggccacaga ggactcactt gcccacaccg agggcgaccc cgtcacagcc   1440

tcaagtcact cccaagcccc ctccttgtct gtgcatccgg gggcagctct ggagggggtt   1500

tgctggggaa ctggcgccat cgccgggact ccagaaccgc agaagcctcc ccagctcacc   1560

cctggaggac ggccggctct ctatagcacc agggctcacg tgggaacccc cctcccaccc   1620

accgccacaa taaagatcgc ccccacctcc accctcaaaa aaaaaaaaaa aaaaaa       1676


<210>  3635
<211>  269
<212>  PRT
<213>  Homosapiens

<400>  3635

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp 
            20                  25                  30          


Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr 
        35                  40                  45              


Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu 
    50                  55                  60                  


Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp 
65                  70                  75                  80  


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 
                85                  90                  95      


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
            100                 105                 110         


Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 
        115                 120                 125             


Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 
    130                 135                 140                 


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
145                 150                 155                 160 


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
                165                 170                 175     


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 
            180                 185                 190         


Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 
        195                 200                 205             


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
    210                 215                 220                 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
225                 230                 235                 240 


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
                245                 250                 255     


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
            260                 265                 


<210>  3636
<211>  1766
<212>  DNA
<213>  Homosapiens

<400>  3636
ttcggcttag tctgcggtcc tcttgcattg cgactccgag tttaacttcc aacacacact     60

ttcaacctcc aagagacgcc cccacctgtg tcgccccaat agcgactttt ctcaccgtgg    120

tcgccgcgga acttcaaggg tccttcctac ccgcgttgct gagagtctgg gtttacgcgt    180

cacctcgggc gggacccgat cctccgctcc tgaggccccc acaatgaagc agtcggacgc    240

gtctccccaa gaaagccggc acagtcttca ctaccgtaga agaccttggc tccaagatac    300

tcctcacctg ctccttgaat gacagcgcca cagaggtcac agggcaccgc tggctgaagg    360

ggggcgtggt gctgaaggag gacgcgctgc ccggccagaa aacggagttc aaggtggact    420

ccgacgacca gtggggagag tactcctgcg tcttcctccc cgagcccatg ggcacggcca    480

acatccagct ccacgggcct cccagagtga aggctgtgaa gtcgtcagaa cacatcaacg    540

agggggagac ggccatgctg gtctgcaagt cagagtccgt gccacctgtc actgactggg    600

cctggtacaa gatcactgac tctgaggaca aggccctcat gaacggctcc gagagcaggt    660

tcttcgtgag ttcctcgcag ggccggtcag agctacacat tgagaacctg aacatggagg    720

ccgaccccgg ccagtaccgg tgcaacggca ccagctccaa gggctccgac caggccatca    780

tcacgctccg cgtgcgcagc cacctggccg ccctctggcc cttcctgggc atcgtggctg    840

aggtgctggt gctggtcacc atcatcttca tctacgagaa gcgccggaag cccgaggacg    900

tcctggatga tgacgacgcc ggctctgcac ccctgaagag cagcgggcag caccagaatg    960

acaaaggcaa gaacgtccgc cagaggaact cttcctgagg caggtggccc gaggacgctc   1020

cctgctccac gtctgcgccg ccgccggagt ccactcccag tgcttgcaag attccaagtt   1080

ctcacctctt aaagaaaacc caccccgtag attcccatca tacacttcct tcttttttaa   1140

aaaagttggg ttttctccat tcaggattct gttccttagg tttttttcct tctgaagtgt   1200

ttcacgagag cccgggagct gctgccctgc ggccccgtct gtggctttca gcctctgggt   1260

ctgagtcatg gccgggtggg cggcacagcc ttctccactg gccggagtca gtgccaggtc   1320

cttgcccttt gtggaaagtc acaggtcaca cgaggggccc cgtgtcctgc ctgtctgaag   1380

ccaatgctgt ctggttgcgc catttttgtg cttttatgtt taattttatg agggccacgg   1440

gtctgtgttc gactcagcct cagggacgac tctgacctct tggccacaga ggactcactt   1500

gcccacaccg agggcgaccc cgtcacagcc tcaagtcact cccaagcccc ctccttgtct   1560

gtgcatccgg gggcagctct ggagggggtt tgctggggaa ctggcgccat cgccgggact   1620

ccagaaccgc agaagcctcc ccagctcacc cctggaggac ggccggctct ctatagcacc   1680

agggctcacg tgggaacccc cctcccaccc accgccacaa taaagatcgc ccccacctcc   1740

accctcaaaa aaaaaaaaaa aaaaaa                                        1766


<210>  3637
<211>  176
<212>  PRT
<213>  Homosapiens

<400>  3637

Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala 
1               5                   10                  15      


Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val 
            20                  25                  30          


Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys 
        35                  40                  45              


Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg 
    50                  55                  60                  


Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn 
65                  70                  75                  80  


Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser 
                85                  90                  95      


Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His 
            100                 105                 110         


Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val 
        115                 120                 125             


Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp 
    130                 135                 140                 


Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly 
145                 150                 155                 160 


Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
                165                 170                 175     


<210>  3638
<211>  1609
<212>  DNA
<213>  Homosapiens

<400>  3638
ttcggcttag tctgcggtcc tcttgcattg cgactccgag tttaacttcc aacacacact     60

ttcaacctcc aagagacgcc cccacctgtg tcgccccaat agcgactttt ctcaccgtgg    120

tcgccgcgga acttcaaggg tccttcctac ccgcgttgct gagagtctgg gtttacgcgt    180

cacctcgggc gggacccgat cctccgctcc tgaggccccc acaatgaagc agtcggacgc    240

gtctccccaa gaaagggtgg actccgacga ccagtgggga gagtactcct gcgtcttcct    300

ccccgagccc atgggcacgg ccaacatcca gctccacggg cctcccagag tgaaggctgt    360

gaagtcgtca gaacacatca acgaggggga gacggccatg ctggtctgca agtcagagtc    420

cgtgccacct gtcactgact gggcctggta caagatcact gactctgagg acaaggccct    480

catgaacggc tccgagagca ggttcttcgt gagttcctcg cagggccggt cagagctaca    540

cattgagaac ctgaacatgg aggccgaccc cggccagtac cggtgcaacg gcaccagctc    600

caagggctcc gaccaggcca tcatcacgct ccgcgtgcgc agccacctgg ccgccctctg    660

gcccttcctg ggcatcgtgg ctgaggtgct ggtgctggtc accatcatct tcatctacga    720

gaagcgccgg aagcccgagg acgtcctgga tgatgacgac gccggctctg cacccctgaa    780

gagcagcggg cagcaccaga atgacaaagg caagaacgtc cgccagagga actcttcctg    840

aggcaggtgg cccgaggacg ctccctgctc cacgtctgcg ccgccgccgg agtccactcc    900

cagtgcttgc aagattccaa gttctcacct cttaaagaaa acccaccccg tagattccca    960

tcatacactt ccttcttttt taaaaaagtt gggttttctc cattcaggat tctgttcctt   1020

aggttttttt ccttctgaag tgtttcacga gagcccggga gctgctgccc tgcggccccg   1080

tctgtggctt tcagcctctg ggtctgagtc atggccgggt gggcggcaca gccttctcca   1140

ctggccggag tcagtgccag gtccttgccc tttgtggaaa gtcacaggtc acacgagggg   1200

ccccgtgtcc tgcctgtctg aagccaatgc tgtctggttg cgccattttt gtgcttttat   1260

gtttaatttt atgagggcca cgggtctgtg ttcgactcag cctcagggac gactctgacc   1320

tcttggccac agaggactca cttgcccaca ccgagggcga ccccgtcaca gcctcaagtc   1380

actcccaagc cccctccttg tctgtgcatc cgggggcagc tctggagggg gtttgctggg   1440

gaactggcgc catcgccggg actccagaac cgcagaagcc tccccagctc acccctggag   1500

gacggccggc tctctatagc accagggctc acgtgggaac ccccctccca cccaccgcca   1560

caataaagat cgcccccacc tccaccctca aaaaaaaaaa aaaaaaaaa               1609


<210>  3639
<211>  205
<212>  PRT
<213>  Homosapiens

<400>  3639

Met Lys Gln Ser Asp Ala Ser Pro Gln Glu Arg Val Asp Ser Asp Asp 
1               5                   10                  15      


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 
            20                  25                  30          


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
        35                  40                  45              


Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 
    50                  55                  60                  


Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 
65                  70                  75                  80  


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
                85                  90                  95      


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
            100                 105                 110         


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 
        115                 120                 125             


Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 
    130                 135                 140                 


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
145                 150                 155                 160 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
                165                 170                 175     


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
            180                 185                 190         


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
        195                 200                 205 


<210>  3640
<211>  3459
<212>  DNA
<213>  Homosapiens

<400>  3640
ggccggcggc ggcggcggcg gctccgctcc gcactgcccg gcgccgcctc gccatggacg     60

cgcgcggggg cggcgggcgg cccggggaga gcccgggcgc gacccccgcg ccggggccgc    120

cgccgccgcc gccgcccgcg cccccccaac agcagccgcc gccgccgccg ccgcccgcgc    180

cccccccggg ccccgggccc gcgccccccc agcacccgcc ccgggccgag gcgttgcccc    240

cggaggcggc ggatgagggc ggcccgcggg gccggctccg cagccgcgac agctcgtgcg    300

gccgccccgg caccccgggc gcggcgagca cggccaaggg cagcccgaac ggcgagtgcg    360

ggcgcggcga gccgcagtgc agccccgcgg ggcccgaggg cccggcgcgg gggcccaagg    420

tgtcgttctc gtgccgcggg gcggcctcgg ggcccgcgcc ggggccgggg ccggcggagg    480

aggcgggcag cgaggaggcg ggcccggcgg gggagccgcg cggcagccag gccagcttca    540

tgcagcgcca gttcggcgcg ctcctgcagc cgggcgtcaa caagttctcg ctgcggatgt    600

tcggcagcca gaaggccgtg gagcgcgagc aggagcgcgt caagtcggcg ggggcctgga    660

tcatccaccc gtacagcgac ttcaggttct actgggactt caccatgctg ctgttcatgg    720

tgggaaacct catcatcatc ccagtgggca tcaccttctt caaggatgag accactgccc    780

cgtggatcgt gttcaacgtg gtctcggaca ccttcttcct catggacctg gtgttgaact    840

tccgcaccgg cattgtgatc gaggacaaca cggagatcat cctggacccc gagaagatca    900

agaagaagta tctgcgcacg tggttcgtgg tggacttcgt gtcctccatc cccgtggact    960

acatcttcct tattgtggag aagggcattg actccgaggt ctacaagacg gcacgcgccc   1020

tgcgcatcgt gcgcttcacc aagatcctca gcctcctgcg gctgctgcgc ctctcacgcc   1080

tgatccgcta catccatcag tgggaggaga tcttccacat gacctatgac ctggccagcg   1140

cggtgatgag gatctgcaat ctcatcagca tgatgctgct gctctgccac tgggacggct   1200

gcctgcagtt cctggtgcct atgctgcagg acttcccgcg caactgctgg gtgtccatca   1260

atggcatggt gaaccactcg tggagtgaac tgtactcctt cgcactcttc aaggccatga   1320

gccacatgct gtgcatcggg tacggccggc aggcgcccga gagcatgacg gacatctggc   1380

tgaccatgct cagcatgatt gtgggtgcca cctgctacgc catgttcatc ggccacgcca   1440

ctgccctcat ccagtcgctg gactcctcgc ggcgccagta ccaggagaag tacaagcagg   1500

tggagcagta catgtccttc cacaagctgc cagctgactt ccgccagaag atccacgact   1560

actatgagca ccgttaccag ggcaagatgt ttgacgagga cagcatcctg ggcgagctca   1620

acgggcccct gcgggaggag atcgtcaact tcaactgccg gaagctggtg gcctccatgc   1680

cgctgttcgc caacgccgac cccaacttcg tcacggccat gctgaccaag ctcaagttcg   1740

aggtcttcca gccgggtgac tacatcatcc gcgaaggcac catcgggaag aagatgtact   1800

tcatccagca cggcgtggtc agcgtgctca ctaagggcaa caaggagatg aagctgtccg   1860

atggctccta cttcggggag atctgcctgc tcacccgggg ccgccgcacg gcgagcgtgc   1920

gggccgacac ctactgccgc ctctattcgc tgagcgtgga caacttcaac gaggtgctgg   1980

aggagtaccc catgatgcgg cgcgccttcg agacggtggc catcgaccgc ctggaccgca   2040

tcggcaagaa gaattccatc ctcctgcaca aggtgcagca tgacctcaac tcgggcgtat   2100

tcaacaacca ggagaacgcc atcatccagg agatcgtcaa gtacgaccgc gagatggtgc   2160

agcaggccga gctgggtcag cgcgtgggcc tcttcccgcc gccgccgccg ccgccgcagg   2220

tcacctcggc catcgccacg ctgcagcagg cggcggccat gagcttctgc ccgcaggtgg   2280

cgcggccgct cgtggggccg ctggcgctcg gctcgccgcg cctcgtgcgc cgcccgcccc   2340

cggggcccgc acctgccgcc gcctcacccg ggcccccgcc ccccgccagc cccccgggcg   2400

cgcccgccag cccccgggca ccgcggacct cgccctacgg cggcctgccc gccgcccccc   2460

ttgctgggcc cgccctgccc gcgcgccgcc tgagccgcgc gtcgcgccca ctgtccgcct   2520

cgcagccctc gctgcctcac ggcgcccccg gccccgcggc ctccacacgc ccggccagca   2580

gctccacacc gcgcttgagg cccacgcccg ctgcccgggc cgccgcgccc agcccggacc   2640

gcagggactc ggcctcaccc ggcgccgccg gcggcctgga cccccaggac tccgcgcgct   2700

cgcgcctctc gtccaacttg tgaccctcgc cgaccgcccc gcgggcccag gcgggccagg   2760

ggcggggccg tcatccagac caaagccatg ccattgcgct gccccggccg ccagtccgcc   2820

cagaagccat agacgagacg taggtagccg tagttggacg gacgggcagg gccggcgggg   2880

cagccccctc cgcgcccccg gccgtccccc ctcatcgccc cgcgcccacc cccatcgccc   2940

ctgcccccgg cggcggcctc gcgtgcgagg gggctccctt cacctcggtg cctcagttcc   3000

cccagctgta agacagggac ggggcggccc agtggctgag aggagccggc tgtggagccc   3060

cgcccgcccc ccaccctcta ggtggccccc gtccgaggag gatcgttttc taagtgcaat   3120

acttggcccg ccggcttccc gctgccccca tcgcgctcac gcaataaccg gcccggcccc   3180

cgtccgcgcg cgtcccccgg tgacctcggg gagcagcacc ccgcctccct ccagcactgg   3240

caccgagggg caggcctggc tgcgcagggc gcggggggga ggctggggtc ccgccgccgt   3300

gatgaatgta ctgacgagcc gaggcagcag tgcccccacc gtggcccccc acgccccatt   3360

aacccccaca cccccattcc gcgcaataaa cgacagcatt ggcgccaaaa aaaaaaaaaa   3420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                          3459


<210>  3641
<211>  889
<212>  PRT
<213>  Homosapiens

<400>  3641

Met Asp Ala Arg Gly Gly Gly Gly Arg Pro Gly Glu Ser Pro Gly Ala 
1               5                   10                  15      


Thr Pro Ala Pro Gly Pro Pro Pro Pro Pro Pro Pro Ala Pro Pro Gln 
            20                  25                  30          


Gln Gln Pro Pro Pro Pro Pro Pro Pro Ala Pro Pro Pro Gly Pro Gly 
        35                  40                  45              


Pro Ala Pro Pro Gln His Pro Pro Arg Ala Glu Ala Leu Pro Pro Glu 
    50                  55                  60                  


Ala Ala Asp Glu Gly Gly Pro Arg Gly Arg Leu Arg Ser Arg Asp Ser 
65                  70                  75                  80  


Ser Cys Gly Arg Pro Gly Thr Pro Gly Ala Ala Ser Thr Ala Lys Gly 
                85                  90                  95      


Ser Pro Asn Gly Glu Cys Gly Arg Gly Glu Pro Gln Cys Ser Pro Ala 
            100                 105                 110         


Gly Pro Glu Gly Pro Ala Arg Gly Pro Lys Val Ser Phe Ser Cys Arg 
        115                 120                 125             


Gly Ala Ala Ser Gly Pro Ala Pro Gly Pro Gly Pro Ala Glu Glu Ala 
    130                 135                 140                 


Gly Ser Glu Glu Ala Gly Pro Ala Gly Glu Pro Arg Gly Ser Gln Ala 
145                 150                 155                 160 


Ser Phe Met Gln Arg Gln Phe Gly Ala Leu Leu Gln Pro Gly Val Asn 
                165                 170                 175     


Lys Phe Ser Leu Arg Met Phe Gly Ser Gln Lys Ala Val Glu Arg Glu 
            180                 185                 190         


Gln Glu Arg Val Lys Ser Ala Gly Ala Trp Ile Ile His Pro Tyr Ser 
        195                 200                 205             


Asp Phe Arg Phe Tyr Trp Asp Phe Thr Met Leu Leu Phe Met Val Gly 
    210                 215                 220                 


Asn Leu Ile Ile Ile Pro Val Gly Ile Thr Phe Phe Lys Asp Glu Thr 
225                 230                 235                 240 


Thr Ala Pro Trp Ile Val Phe Asn Val Val Ser Asp Thr Phe Phe Leu 
                245                 250                 255     


Met Asp Leu Val Leu Asn Phe Arg Thr Gly Ile Val Ile Glu Asp Asn 
            260                 265                 270         


Thr Glu Ile Ile Leu Asp Pro Glu Lys Ile Lys Lys Lys Tyr Leu Arg 
        275                 280                 285             


Thr Trp Phe Val Val Asp Phe Val Ser Ser Ile Pro Val Asp Tyr Ile 
    290                 295                 300                 


Phe Leu Ile Val Glu Lys Gly Ile Asp Ser Glu Val Tyr Lys Thr Ala 
305                 310                 315                 320 


Arg Ala Leu Arg Ile Val Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg 
                325                 330                 335     


Leu Leu Arg Leu Ser Arg Leu Ile Arg Tyr Ile His Gln Trp Glu Glu 
            340                 345                 350         


Ile Phe His Met Thr Tyr Asp Leu Ala Ser Ala Val Met Arg Ile Cys 
        355                 360                 365             


Asn Leu Ile Ser Met Met Leu Leu Leu Cys His Trp Asp Gly Cys Leu 
    370                 375                 380                 


Gln Phe Leu Val Pro Met Leu Gln Asp Phe Pro Arg Asn Cys Trp Val 
385                 390                 395                 400 


Ser Ile Asn Gly Met Val Asn His Ser Trp Ser Glu Leu Tyr Ser Phe 
                405                 410                 415     


Ala Leu Phe Lys Ala Met Ser His Met Leu Cys Ile Gly Tyr Gly Arg 
            420                 425                 430         


Gln Ala Pro Glu Ser Met Thr Asp Ile Trp Leu Thr Met Leu Ser Met 
        435                 440                 445             


Ile Val Gly Ala Thr Cys Tyr Ala Met Phe Ile Gly His Ala Thr Ala 
    450                 455                 460                 


Leu Ile Gln Ser Leu Asp Ser Ser Arg Arg Gln Tyr Gln Glu Lys Tyr 
465                 470                 475                 480 


Lys Gln Val Glu Gln Tyr Met Ser Phe His Lys Leu Pro Ala Asp Phe 
                485                 490                 495     


Arg Gln Lys Ile His Asp Tyr Tyr Glu His Arg Tyr Gln Gly Lys Met 
            500                 505                 510         


Phe Asp Glu Asp Ser Ile Leu Gly Glu Leu Asn Gly Pro Leu Arg Glu 
        515                 520                 525             


Glu Ile Val Asn Phe Asn Cys Arg Lys Leu Val Ala Ser Met Pro Leu 
    530                 535                 540                 


Phe Ala Asn Ala Asp Pro Asn Phe Val Thr Ala Met Leu Thr Lys Leu 
545                 550                 555                 560 


Lys Phe Glu Val Phe Gln Pro Gly Asp Tyr Ile Ile Arg Glu Gly Thr 
                565                 570                 575     


Ile Gly Lys Lys Met Tyr Phe Ile Gln His Gly Val Val Ser Val Leu 
            580                 585                 590         


Thr Lys Gly Asn Lys Glu Met Lys Leu Ser Asp Gly Ser Tyr Phe Gly 
        595                 600                 605             


Glu Ile Cys Leu Leu Thr Arg Gly Arg Arg Thr Ala Ser Val Arg Ala 
    610                 615                 620                 


Asp Thr Tyr Cys Arg Leu Tyr Ser Leu Ser Val Asp Asn Phe Asn Glu 
625                 630                 635                 640 


Val Leu Glu Glu Tyr Pro Met Met Arg Arg Ala Phe Glu Thr Val Ala 
                645                 650                 655     


Ile Asp Arg Leu Asp Arg Ile Gly Lys Lys Asn Ser Ile Leu Leu His 
            660                 665                 670         


Lys Val Gln His Asp Leu Asn Ser Gly Val Phe Asn Asn Gln Glu Asn 
        675                 680                 685             


Ala Ile Ile Gln Glu Ile Val Lys Tyr Asp Arg Glu Met Val Gln Gln 
    690                 695                 700                 


Ala Glu Leu Gly Gln Arg Val Gly Leu Phe Pro Pro Pro Pro Pro Pro 
705                 710                 715                 720 


Pro Gln Val Thr Ser Ala Ile Ala Thr Leu Gln Gln Ala Ala Ala Met 
                725                 730                 735     


Ser Phe Cys Pro Gln Val Ala Arg Pro Leu Val Gly Pro Leu Ala Leu 
            740                 745                 750         


Gly Ser Pro Arg Leu Val Arg Arg Pro Pro Pro Gly Pro Ala Pro Ala 
        755                 760                 765             


Ala Ala Ser Pro Gly Pro Pro Pro Pro Ala Ser Pro Pro Gly Ala Pro 
    770                 775                 780                 


Ala Ser Pro Arg Ala Pro Arg Thr Ser Pro Tyr Gly Gly Leu Pro Ala 
785                 790                 795                 800 


Ala Pro Leu Ala Gly Pro Ala Leu Pro Ala Arg Arg Leu Ser Arg Ala 
                805                 810                 815     


Ser Arg Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro His Gly Ala Pro 
            820                 825                 830         


Gly Pro Ala Ala Ser Thr Arg Pro Ala Ser Ser Ser Thr Pro Arg Leu 
        835                 840                 845             


Arg Pro Thr Pro Ala Ala Arg Ala Ala Ala Pro Ser Pro Asp Arg Arg 
    850                 855                 860                 


Asp Ser Ala Ser Pro Gly Ala Ala Gly Gly Leu Asp Pro Gln Asp Ser 
865                 870                 875                 880 


Ala Arg Ser Arg Leu Ser Ser Asn Leu 
                885                 


<210>  3642
<211>  3832
<212>  DNA
<213>  Homosapiens

<400>  3642
cggcggcggc ggcgcctgga gcggcgtgcg taatgtcggc actttgctgg ggccgcggag     60

cggcggggct caaacgagcc ctacggcctt gcggccgccc gggactcccc ggcaaagaag    120

ggaccgccgg tggcgtctgc ggccccagga ggagctcgtc cgccagcccc caggagcaag    180

accaagaccg caggaaggac tggggccacg tggagctgct ggaggtgctc caggcgcggg    240

tgcggcagct gcaggctgag agcgtgtcgg aggtggtggt gaacagggtg gatgtggcgc    300

ggctcccaga atgtggcagt ggagatggta gcctccagcc acccaggaag gtccagatgg    360

gggccaagga tgccaccccg gtgccctgtg gccgctgggc aaagatactg gagaaggata    420

agcggaccca gcagatgcgt atgcagcggt tgaaggcgaa gctgcagatg ccattccaga    480

gcggggagtt caaggcgctg accaggcgcc tgcaggtgga gccccggctc ctgagcaagc    540

agatggccgg gtgcctggag gactgcacgc gccaggcccc cgagagcccc tgggaggagc    600

agctggcccg gctgctgcag gaggcccctg ggaagctgag cctcgatgtg gagcaggccc    660

cgtcggggca gcactcgcag gcccagctct caggtcagca gcagaggctc ctggccttct    720

tcaagtgctg cctgctcact gaccagctgc ccctcgccca ccacctgctg gtcgtccacc    780

acggccagcg gcagaagcgg aagctgctca cgctggacat gtacaacgcc gtgatgcttg    840

gctgggcgcg gcagggtgcc ttcaaggagc tggtatatgt gttattcatg gtgaaggatg    900

ccggcttgac cccggacctg ctgtcctatg cggctgccct ccagtgcatg gggaggcagg    960

accaggacgc cgggaccatc gaaaggtgtc tggaacagat gagccaggag gggctgaagc   1020

tgcaggcact cttcaccgcc gttctgctgt ctgaggagga tcgggccact gttctgaagg   1080

ccgtgcacaa ggtgaagccc accttcagcc tcccgccgca gctgccgccc ccggtcaaca   1140

cctccaagct gctcagggac gtgtatgcca aggatgggcg tgtgtcctac ccgaagctgc   1200

acctgccctt gaagaccctg cagtgcttct ttgagaagca gctccacatg gagctggcca   1260

gcagggtgtg cgtggtgtcc gtggagaagc ccacgttgcc aagcaaggag gtcaagcacg   1320

cgcggaagac cctgaagacc ctgcgggacc aatgggagaa agcactgtgc cgggcgctgc   1380

gggagaccaa gaaccgccta gagcgcgagg tgtacgaggg ccggttctca ctttacccct   1440

tcctgtgcct gctggacgag cgcgaggtgg tgcggatgct cctgcaggtc ctgcaggcgc   1500

tgcccgccca aggtgagtcc ttcaccaccc tggcccggga gctgagtgcg cgcactttca   1560

gccggcacgt ggtgcagagg cagcgggtca gtggccaggt gcaggcgctg cagaaccact   1620

acaggaagta cctctgcttg ctggcctccg acgccgaggt gcccgagccc tgcctgccgc   1680

ggcagtactg ggaggagctg ggggcgcccg aggccctgcg ggagcagccc tggcccctgc   1740

cagtgcagat ggagctgggc aagctgctgg cggagatgct ggtgcaggct acgcagatgc   1800

catgcagcct ggacaagccg catcgttcct ctcggcttgt ccccgtgctc taccacgtgt   1860

attccttccg caacgtccag caaatcggca tcctgaagcc gcacccggcc tacgtgcagc   1920

tgctggagaa ggccgcggaa cccacgctga ccttcgaggc ggtggatgta cccatgcttt   1980

gccccccgct gccctggaca tcgccgcact ctggtgcttt cctgctcagc cccaccaagc   2040

tgatgcgcac ggtggaaggc gccacgcagc accaggagct gctggaaacc tgcccgccca   2100

ccgcgctgca tggcgcactg gacgccctca cccaactggg caactgcgcc tggcgcgtca   2160

acgggcgcgt gctggacctg gtgctgcagc tcttccaggc caagggctgc ccccagctag   2220

gcgtgccggc cccgccctcc gaggcgcccc agccgcccga ggcccacctg ccgcacagcg   2280

ccgcgcccgc ccgcaaggcc gagctgcgcc gtgagctggc gcactgccag aaggtggccc   2340

gggagatgca cagcctgcgg gcggaggcgc tgtaccgcct ctcgctggcg cagcacctgc   2400

gggaccgcgt cttctggctg ccgcacaaca tggacttccg cggccgcacc tacccctgcc   2460

cgccgcactt caaccacctg ggcagcgacg tggcgcgggc cctgctggag ttcgcccagg   2520

gccgcccgct cggcccgcac ggcctggatt ggctcaagat ccacctggtc aatctcacgg   2580

ggttgaagaa gcgggagccg ctgcggaagc gcctggcctt tgcggaggag gtgatggatg   2640

acatcctgga ctccgcggac caacccttga cgggccgaaa gtggtggatg ggcgcggagg   2700

aaccctggca gacgctggcc tgctgtatgg aggtggcgaa cgctgtgcgc gcctccgacc   2760

ctgccgccta tgtctcccac ctccccgtcc atcaggacgg ctcttgcaac ggcctgcagc   2820

attatgctgc tctgggccgc gacagcgtgg gcgccgcctc cgtcaacctg gagccctcgg   2880

atgtgccgca ggacgtgtac agcggcgtgg ccgcgcaggt ggaggtgttc cgtaggcagg   2940

acgcccagcg gggcatgcgg gtggcacagg tgctggaagg tttcatcacc cgcaaggtgg   3000

tgaagcagac ggtgatgacg gtggtgtacg gggtcacgcg ctatggcggg cgcctgcaga   3060

ttgagaagcg cctccgggag ctgagcgact ttccccagga gttcgtgtgg gaggcctctc   3120

actatctcgt acgccaggtc ttcaagagtc tacaggagat gttctcgggg acccgggcca   3180

tccagcactg gctgaccgag agtgcccgcc tcatctccca catgggctct gtggtggagt   3240

gggtcacacc cctgggcgtc cccgtcatcc agccgtatcg cctggactcc aaggtcaagc   3300

aaataggagg tggaattcag agcatcacct acacccacaa cggagacatc agccgaaagc   3360

ccaacacacg taagcagaag aacggcttcc cgcccaactt catccactcg ctggactcct   3420

cccacatgat gctcaccgcc ctgcactgct acaggaaggg cctgaccttc gtctctgtgc   3480

acgactgtta ctggactcac gcagctgatg tctccgtcat gaaccaggtg tgccgggagc   3540

agtttgtccg cttgcacagc gagcccatcc tgcaggacct gtccagattc ctggtcaagc   3600

ggttctgctc tgagccccag aagatcttgg aggccagcca gctgaaggag acactgcagg   3660

cggtgcccaa gccaggggcc ttcgacctgg agcaggtgaa gcgttccacc tacttcttca   3720

gctgacaccc cgtgagcctt gtcagtgtgt aaataaagct cttttgccac cccccaaaaa   3780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa           3832


<210>  3643
<211>  1230
<212>  PRT
<213>  Homosapiens

<400>  3643

Met Ser Ala Leu Cys Trp Gly Arg Gly Ala Ala Gly Leu Lys Arg Ala 
1               5                   10                  15      


Leu Arg Pro Cys Gly Arg Pro Gly Leu Pro Gly Lys Glu Gly Thr Ala 
            20                  25                  30          


Gly Gly Val Cys Gly Pro Arg Arg Ser Ser Ser Ala Ser Pro Gln Glu 
        35                  40                  45              


Gln Asp Gln Asp Arg Arg Lys Asp Trp Gly His Val Glu Leu Leu Glu 
    50                  55                  60                  


Val Leu Gln Ala Arg Val Arg Gln Leu Gln Ala Glu Ser Val Ser Glu 
65                  70                  75                  80  


Val Val Val Asn Arg Val Asp Val Ala Arg Leu Pro Glu Cys Gly Ser 
                85                  90                  95      


Gly Asp Gly Ser Leu Gln Pro Pro Arg Lys Val Gln Met Gly Ala Lys 
            100                 105                 110         


Asp Ala Thr Pro Val Pro Cys Gly Arg Trp Ala Lys Ile Leu Glu Lys 
        115                 120                 125             


Asp Lys Arg Thr Gln Gln Met Arg Met Gln Arg Leu Lys Ala Lys Leu 
    130                 135                 140                 


Gln Met Pro Phe Gln Ser Gly Glu Phe Lys Ala Leu Thr Arg Arg Leu 
145                 150                 155                 160 


Gln Val Glu Pro Arg Leu Leu Ser Lys Gln Met Ala Gly Cys Leu Glu 
                165                 170                 175     


Asp Cys Thr Arg Gln Ala Pro Glu Ser Pro Trp Glu Glu Gln Leu Ala 
            180                 185                 190         


Arg Leu Leu Gln Glu Ala Pro Gly Lys Leu Ser Leu Asp Val Glu Gln 
        195                 200                 205             


Ala Pro Ser Gly Gln His Ser Gln Ala Gln Leu Ser Gly Gln Gln Gln 
    210                 215                 220                 


Arg Leu Leu Ala Phe Phe Lys Cys Cys Leu Leu Thr Asp Gln Leu Pro 
225                 230                 235                 240 


Leu Ala His His Leu Leu Val Val His His Gly Gln Arg Gln Lys Arg 
                245                 250                 255     


Lys Leu Leu Thr Leu Asp Met Tyr Asn Ala Val Met Leu Gly Trp Ala 
            260                 265                 270         


Arg Gln Gly Ala Phe Lys Glu Leu Val Tyr Val Leu Phe Met Val Lys 
        275                 280                 285             


Asp Ala Gly Leu Thr Pro Asp Leu Leu Ser Tyr Ala Ala Ala Leu Gln 
    290                 295                 300                 


Cys Met Gly Arg Gln Asp Gln Asp Ala Gly Thr Ile Glu Arg Cys Leu 
305                 310                 315                 320 


Glu Gln Met Ser Gln Glu Gly Leu Lys Leu Gln Ala Leu Phe Thr Ala 
                325                 330                 335     


Val Leu Leu Ser Glu Glu Asp Arg Ala Thr Val Leu Lys Ala Val His 
            340                 345                 350         


Lys Val Lys Pro Thr Phe Ser Leu Pro Pro Gln Leu Pro Pro Pro Val 
        355                 360                 365             


Asn Thr Ser Lys Leu Leu Arg Asp Val Tyr Ala Lys Asp Gly Arg Val 
    370                 375                 380                 


Ser Tyr Pro Lys Leu His Leu Pro Leu Lys Thr Leu Gln Cys Phe Phe 
385                 390                 395                 400 


Glu Lys Gln Leu His Met Glu Leu Ala Ser Arg Val Cys Val Val Ser 
                405                 410                 415     


Val Glu Lys Pro Thr Leu Pro Ser Lys Glu Val Lys His Ala Arg Lys 
            420                 425                 430         


Thr Leu Lys Thr Leu Arg Asp Gln Trp Glu Lys Ala Leu Cys Arg Ala 
        435                 440                 445             


Leu Arg Glu Thr Lys Asn Arg Leu Glu Arg Glu Val Tyr Glu Gly Arg 
    450                 455                 460                 


Phe Ser Leu Tyr Pro Phe Leu Cys Leu Leu Asp Glu Arg Glu Val Val 
465                 470                 475                 480 


Arg Met Leu Leu Gln Val Leu Gln Ala Leu Pro Ala Gln Gly Glu Ser 
                485                 490                 495     


Phe Thr Thr Leu Ala Arg Glu Leu Ser Ala Arg Thr Phe Ser Arg His 
            500                 505                 510         


Val Val Gln Arg Gln Arg Val Ser Gly Gln Val Gln Ala Leu Gln Asn 
        515                 520                 525             


His Tyr Arg Lys Tyr Leu Cys Leu Leu Ala Ser Asp Ala Glu Val Pro 
    530                 535                 540                 


Glu Pro Cys Leu Pro Arg Gln Tyr Trp Glu Glu Leu Gly Ala Pro Glu 
545                 550                 555                 560 


Ala Leu Arg Glu Gln Pro Trp Pro Leu Pro Val Gln Met Glu Leu Gly 
                565                 570                 575     


Lys Leu Leu Ala Glu Met Leu Val Gln Ala Thr Gln Met Pro Cys Ser 
            580                 585                 590         


Leu Asp Lys Pro His Arg Ser Ser Arg Leu Val Pro Val Leu Tyr His 
        595                 600                 605             


Val Tyr Ser Phe Arg Asn Val Gln Gln Ile Gly Ile Leu Lys Pro His 
    610                 615                 620                 


Pro Ala Tyr Val Gln Leu Leu Glu Lys Ala Ala Glu Pro Thr Leu Thr 
625                 630                 635                 640 


Phe Glu Ala Val Asp Val Pro Met Leu Cys Pro Pro Leu Pro Trp Thr 
                645                 650                 655     


Ser Pro His Ser Gly Ala Phe Leu Leu Ser Pro Thr Lys Leu Met Arg 
            660                 665                 670         


Thr Val Glu Gly Ala Thr Gln His Gln Glu Leu Leu Glu Thr Cys Pro 
        675                 680                 685             


Pro Thr Ala Leu His Gly Ala Leu Asp Ala Leu Thr Gln Leu Gly Asn 
    690                 695                 700                 


Cys Ala Trp Arg Val Asn Gly Arg Val Leu Asp Leu Val Leu Gln Leu 
705                 710                 715                 720 


Phe Gln Ala Lys Gly Cys Pro Gln Leu Gly Val Pro Ala Pro Pro Ser 
                725                 730                 735     


Glu Ala Pro Gln Pro Pro Glu Ala His Leu Pro His Ser Ala Ala Pro 
            740                 745                 750         


Ala Arg Lys Ala Glu Leu Arg Arg Glu Leu Ala His Cys Gln Lys Val 
        755                 760                 765             


Ala Arg Glu Met His Ser Leu Arg Ala Glu Ala Leu Tyr Arg Leu Ser 
    770                 775                 780                 


Leu Ala Gln His Leu Arg Asp Arg Val Phe Trp Leu Pro His Asn Met 
785                 790                 795                 800 


Asp Phe Arg Gly Arg Thr Tyr Pro Cys Pro Pro His Phe Asn His Leu 
                805                 810                 815     


Gly Ser Asp Val Ala Arg Ala Leu Leu Glu Phe Ala Gln Gly Arg Pro 
            820                 825                 830         


Leu Gly Pro His Gly Leu Asp Trp Leu Lys Ile His Leu Val Asn Leu 
        835                 840                 845             


Thr Gly Leu Lys Lys Arg Glu Pro Leu Arg Lys Arg Leu Ala Phe Ala 
    850                 855                 860                 


Glu Glu Val Met Asp Asp Ile Leu Asp Ser Ala Asp Gln Pro Leu Thr 
865                 870                 875                 880 


Gly Arg Lys Trp Trp Met Gly Ala Glu Glu Pro Trp Gln Thr Leu Ala 
                885                 890                 895     


Cys Cys Met Glu Val Ala Asn Ala Val Arg Ala Ser Asp Pro Ala Ala 
            900                 905                 910         


Tyr Val Ser His Leu Pro Val His Gln Asp Gly Ser Cys Asn Gly Leu 
        915                 920                 925             


Gln His Tyr Ala Ala Leu Gly Arg Asp Ser Val Gly Ala Ala Ser Val 
    930                 935                 940                 


Asn Leu Glu Pro Ser Asp Val Pro Gln Asp Val Tyr Ser Gly Val Ala 
945                 950                 955                 960 


Ala Gln Val Glu Val Phe Arg Arg Gln Asp Ala Gln Arg Gly Met Arg 
                965                 970                 975     


Val Ala Gln Val Leu Glu Gly Phe Ile Thr Arg Lys Val Val Lys Gln 
            980                 985                 990         


Thr Val Met Thr Val Val Tyr Gly  Val Thr Arg Tyr Gly  Gly Arg Leu 
        995                 1000                 1005             


Gln Ile  Glu Lys Arg Leu Arg  Glu Leu Ser Asp Phe  Pro Gln Glu 
    1010                 1015                 1020             


Phe Val  Trp Glu Ala Ser His  Tyr Leu Val Arg Gln  Val Phe Lys 
    1025                 1030                 1035             


Ser Leu  Gln Glu Met Phe Ser  Gly Thr Arg Ala Ile  Gln His Trp 
    1040                 1045                 1050             


Leu Thr  Glu Ser Ala Arg Leu  Ile Ser His Met Gly  Ser Val Val 
    1055                 1060                 1065             


Glu Trp  Val Thr Pro Leu Gly  Val Pro Val Ile Gln  Pro Tyr Arg 
    1070                 1075                 1080             


Leu Asp  Ser Lys Val Lys Gln  Ile Gly Gly Gly Ile  Gln Ser Ile 
    1085                 1090                 1095             


Thr Tyr  Thr His Asn Gly Asp  Ile Ser Arg Lys Pro  Asn Thr Arg 
    1100                 1105                 1110             


Lys Gln  Lys Asn Gly Phe Pro  Pro Asn Phe Ile His  Ser Leu Asp 
    1115                 1120                 1125             


Ser Ser  His Met Met Leu Thr  Ala Leu His Cys Tyr  Arg Lys Gly 
    1130                 1135                 1140             


Leu Thr  Phe Val Ser Val His  Asp Cys Tyr Trp Thr  His Ala Ala 
    1145                 1150                 1155             


Asp Val  Ser Val Met Asn Gln  Val Cys Arg Glu Gln  Phe Val Arg 
    1160                 1165                 1170             


Leu His  Ser Glu Pro Ile Leu  Gln Asp Leu Ser Arg  Phe Leu Val 
    1175                 1180                 1185             


Lys Arg  Phe Cys Ser Glu Pro  Gln Lys Ile Leu Glu  Ala Ser Gln 
    1190                 1195                 1200             


Leu Lys  Glu Thr Leu Gln Ala  Val Pro Lys Pro Gly  Ala Phe Asp 
    1205                 1210                 1215             


Leu Glu  Gln Val Lys Arg Ser  Thr Tyr Phe Phe Ser  
    1220                 1225                 1230 


<210>  3644
<211>  513
<212>  DNA
<213>  Homosapiens

<400>  3644
atgcgccgcc gcctgtggct gggcctggcc tggctgctgc tggcgcgggc gccggacgcc     60

gcgggaaccc cgagcgcgtc gcggggaccg cgcagctacc cgcacctgga gggcgacgtg    120

cgctggcggc gcctcttctc ctccactcac ttcttcctgc gcgtggatcc cggcggccgc    180

gtgcagggca cccgctggcg ccacggccag gacagcatcc tggagatccg ctctgtacac    240

gtgggcgtcg tggtcatcaa agcagtgtcc tcaggcttct acgtggccat gaaccgccgg    300

ggccgcctct acgggtcgcg actctacacc gtggactgca ggttccggga gcgcatcgaa    360

gagaacggcc acaacaccta cgcctcacag cgctggcgcc gccgcggcca gcccatgttc    420

ctggcgctgg acaggagggg ggggccccgg ccaggcggcc ggacgcggcg gtaccacctg    480

tccgcccact tcctgcccgt cctggtctcc tga                                 513


<210>  3645
<211>  170
<212>  PRT
<213>  Homosapiens

<400>  3645

Met Arg Arg Arg Leu Trp Leu Gly Leu Ala Trp Leu Leu Leu Ala Arg 
1               5                   10                  15      


Ala Pro Asp Ala Ala Gly Thr Pro Ser Ala Ser Arg Gly Pro Arg Ser 
            20                  25                  30          


Tyr Pro His Leu Glu Gly Asp Val Arg Trp Arg Arg Leu Phe Ser Ser 
        35                  40                  45              


Thr His Phe Phe Leu Arg Val Asp Pro Gly Gly Arg Val Gln Gly Thr 
    50                  55                  60                  


Arg Trp Arg His Gly Gln Asp Ser Ile Leu Glu Ile Arg Ser Val His 
65                  70                  75                  80  


Val Gly Val Val Val Ile Lys Ala Val Ser Ser Gly Phe Tyr Val Ala 
                85                  90                  95      


Met Asn Arg Arg Gly Arg Leu Tyr Gly Ser Arg Leu Tyr Thr Val Asp 
            100                 105                 110         


Cys Arg Phe Arg Glu Arg Ile Glu Glu Asn Gly His Asn Thr Tyr Ala 
        115                 120                 125             


Ser Gln Arg Trp Arg Arg Arg Gly Gln Pro Met Phe Leu Ala Leu Asp 
    130                 135                 140                 


Arg Arg Gly Gly Pro Arg Pro Gly Gly Arg Thr Arg Arg Tyr His Leu 
145                 150                 155                 160 


Ser Ala His Phe Leu Pro Val Leu Val Ser 
                165                 170 


<210>  3646
<211>  2895
<212>  DNA
<213>  Homosapiens

<400>  3646
ttaaaaccag aaacaccagc gttaaagcgc cagggcccag cgcctctgcc ccacgcttcg     60

gtcacacctc agccacgcgg gttcctggcc ccttctgaaa agccggaccc cactgctcaa    120

ggttgctgga tgcctggccc ggggtgcagc cagctcgggc acagctggca aggcgtgggg    180

acctgcgggc tcagggggcc ggggcagtgg gttcatctca gttgctgatg atcccaccat    240

cctgggatcc aagaatcaga cgatggagac ggctaacgga gaggagcctc cagcaggacc    300

acccgtgtcc ctccacggta gacggctcct gcgcgtggga ggcgcgtgcc ccacgcccct    360

acctgttctc caaagactcc cgccctccgc tctgcaccac actcttcacc gtgtcccgcg    420

acgtgtctgc gtcagccccc ttggccaggt aactcggatc ccacctgtcc ggaccgtgcg    480

cagggcacct tctgggctgc tgccgcaacg ccgtggcggg ccctcctggt ggccgccctc    540

tggggtcgcg cgtggcgggc cctcctggtg gccgccctct ggggtcgtgc gtggcgggcc    600

ctcctcgtgg ccgccctctg gggttgcgga gccgagagaa gcgttgggac ttccatgact    660

gtggccgcca gggcagagtg ccagccctga gggcgtccac atctcaaccc caggacccgc    720

ggactcggct cctcacgagg taacgtaccc ggtgccctaa gacgaggttg catggaggac    780

accgaggtag ggaggttacc tcggatcgtc cttgatctcc ggactgagag aacaagtgtt    840

ttaggccccg agtctgcgcg acaggctggg ccgcctgctc cgggtcacag tcccccggcc    900

gagccgtttt cctgttggaa gatggagttt tgagtcagga ggcgttgagg gagacaaggc    960

tcgggttctg tgtgtccgtg gtggttcttg ggagttggag ttggagctgg agaggagggc   1020

tgggcaggtg aggcttgcag cggcgggacc tggagactcg gaactggagg gcctttgtca   1080

gagatgctgc cggggtgtgc gcctgcctgt gaggctggga cttccctcgc gtggagtggc   1140

cagaggagca ggaccgattg gttcgcccca cccaggcatg agcctcgggg gcgctgggcc   1200

cagaggacac cggcaccctg gtgggggctg tgaggccgca ttgctcgagg tcagacagca   1260

gtaagaagtg gccgcccctg gtgtcttccc tgccccagga gcctgctgca cgacaggaca   1320

gggccctggt aaggcccgca cccctgcgtc cccgggcccc tcgcgcctgc agccgtcctc   1380

tccccatccg ccctgccgct caggagggct tcgtaagcgg aagcacagtt tgcaacagtt   1440

tggggttgtc ttattttcac tgctggcgat ttcctgggga gccgctggtt ctgtgccccc   1500

aggccgctcc tctctgttgg ggggccccca cctcactgcc tgaggacaac gggggtcccc   1560

aggtttgggc ttgcgaataa gctgctgagg gctctgtgtg aaccgggatt tcactgccct   1620

gggatgtgcg gagctgtacg cccattccac gctctgtttt agaaacaaag aaacaactgc   1680

tgacctgttt cttttttttt tttttttgag acggagtctc gctgtgtcgc ccaggctgga   1740

gtgcagtggc gcgatctcag ctcactgcaa cctccgcctc ccggattcaa gcgattcccc   1800

gcctcagcct ctcaagtagc tggaattaca ggcgcccgcc accacgcccg gctaattttt   1860

tgtattttta gtagacacgg ggtttcacca tgttgaccaa gatggccttg atctcctgac   1920

ctcgtgatcc acccgcctcg gcctcccaaa gtgctgggat gacaggcgtg agcccccgcg   1980

cccggcctgc tgacccgttt ctacgaggca catgttacgt tcctgcgtgg ggtgccagca   2040

agttttattt cagctgtggt gacctgtgca gctcccagtg acaactcaag tggcgacgcc   2100

ctccgactgg ccaacgtggg ccgatctccc ctcacactgc caacctgggg acatcctggg   2160

tgcagccctg tcctccaccc actccatgcc agccaaagat gtccccagag gccgcctggt   2220

gtcccctggg gtggggctcg cttctgtctg cagggtgagc agaagctctc gggccgggca   2280

cgaccctccc ttcccagaag ggttttcggt gtcaggctgc tcagcacctc ccagcaagtg   2340

cctcggccca gtcttcctgt atttatgtgg aaggcggcgg ctggggacgg agccctggcc   2400

gtccccgggg acttcaccag ggcgatgctg ctgtcgcccc acgcacagaa ggggagacgg   2460

gcccagggtg tcactgcctg gctccaggct gtggggctct tggctctgac cttttctctg   2520

agaggctgga gtttgactcc cagggctgta ggcagaagtc ccagcggagt caggatgtca   2580

ggagggcgct gggcacaggt gggggcgccc ccacaccgac ggccagccct ctctgcgtcc   2640

cgcaggacag cggcatgaag cccccaggcc tgccctgcac ccagcacggc tcctgccctc   2700

agcctctgcc cttcccgggg ggatttgagg agcaccgagg cgtcggcctc cgcccttccc   2760

gggggatccg aggagcaccg aggcgtcggc ctccgccctt cccgggggga tctgaggctt   2820

attttgtcat gagaacagtt tcagacaccg tgtgcatatt tccgacgtct gctgtaacaa   2880

aagaccacaa agttg                                                    2895


<210>  3647
<211>  131
<212>  PRT
<213>  Homosapiens

<400>  3647

Met Glu Thr Ala Asn Gly Glu Glu Pro Pro Ala Gly Pro Pro Val Ser 
1               5                   10                  15      


Leu His Gly Arg Arg Leu Leu Arg Val Gly Gly Ala Cys Pro Thr Pro 
            20                  25                  30          


Leu Pro Val Leu Gln Arg Leu Pro Pro Ser Ala Leu His His Thr Leu 
        35                  40                  45              


His Arg Val Pro Arg Arg Val Cys Val Ser Pro Leu Gly Gln Val Thr 
    50                  55                  60                  


Arg Ile Pro Pro Val Arg Thr Val Arg Arg Ala Pro Ser Gly Leu Leu 
65                  70                  75                  80  


Pro Gln Arg Arg Gly Gly Pro Ser Trp Trp Pro Pro Ser Gly Val Ala 
                85                  90                  95      


Arg Gly Gly Pro Ser Trp Trp Pro Pro Ser Gly Val Val Arg Gly Gly 
            100                 105                 110         


Pro Ser Ser Trp Pro Pro Ser Gly Val Ala Glu Pro Arg Glu Ala Leu 
        115                 120                 125             


Gly Leu Pro 
    130     


<210>  3648
<211>  1457
<212>  DNA
<213>  Homosapiens

<400>  3648
gccgtgcgtg agcgtgcgcg ggcgcgtcgg ccggcgaggg agcagcaaac ggccggcggc     60

gggtgccgcg cggggggcgg gcggcgcgga gtaggtggcg gcggccatgg ccgaggcgtc    120

gccgcatccc ggacggtact tctgccactg ctgctccgtg gagatcgtcc cgcgcctgcc    180

ggattatatc tgtccaagat gcgagtctgg ttttatcgag gagcttccgg aagagaccag    240

gagcacagaa aatggttctg ccccctccac agctcccaca gaccagagcc ggccaccgtt    300

ggagcacgtg gaccagcacc tgttcacgct gccgcagggc tacggacagt ttgctttcgg    360

catcttcgat gacagcttcg agatccccac gttccctcct ggggcgcagg ctgacgacgg    420

cagggaccct gagagccggc gggagagaga ccatccgtcc cggcaccggt acggcgcccg    480

acagccccgc gcccgcctca ccacgcggcg ggccaccggc cggcacgaag gcgtccccac    540

gctggaaggg atcatccagc agctcgtcaa cggcatcatc acgcccgcca ccatccccag    600

cctgggcccc tggggagtcc tgcactcaaa ccctatggac tacgcctggg gggccaacgg    660

cctggatgcc atcatcacac agctcctcaa tcagtttgaa aacacaggcc ccccaccggc    720

agataaagag aaaatccagg ccctccccac cgtccccgtc actgaggagc acgtaggctc    780

cgggctcgag tgccctgtgt gcaaggacga ctacgcgctg ggtgagcgtg tgcggcagct    840

gccctgcaac cacctgttcc acgacggctg catcgtgccc tggctggagc agcacgacag    900

ctgccccgtc tgccgaaaaa gcctcacggg acagaacacg gccacgaacc cccctggcct    960

cactggggtg agcttctcct cctcgtcgtc atcgtcctcc tccagctcgc ccagcaacga   1020

gaacgccaca tggtcccctc tggggcgtcc ccagcctccc cgtcctctgt ctaacctcac   1080

cctctaaacg ttcagcggtg gaaagatttt tataatttta aattattact gctttgaaat   1140

aaacggacgt ttgagctcac gtggcggcca tgcatggttt gtggcggaag acggggccca   1200

gcggctcccc cagcgctgaa gcacggggtt cagcggctcc cccagtgctg caggtgccgc   1260

caggacgggc cacgtgggcc cccagcctcc ccctcggccg cctccacgac ccggagtagg   1320

ggggctcggg accatgagga tgaccagcaa aattcaagaa caaaactgct ccaacagact   1380

tttttaaagg aaaaaatatg tgtatcttga aagctattta aaatacacta cttacaaaga   1440

gaaaaaaaaa aaaaaaa                                                  1457


<210>  3649
<211>  326
<212>  PRT
<213>  Homosapiens

<400>  3649

Met Ala Glu Ala Ser Pro His Pro Gly Arg Tyr Phe Cys His Cys Cys 
1               5                   10                  15      


Ser Val Glu Ile Val Pro Arg Leu Pro Asp Tyr Ile Cys Pro Arg Cys 
            20                  25                  30          


Glu Ser Gly Phe Ile Glu Glu Leu Pro Glu Glu Thr Arg Ser Thr Glu 
        35                  40                  45              


Asn Gly Ser Ala Pro Ser Thr Ala Pro Thr Asp Gln Ser Arg Pro Pro 
    50                  55                  60                  


Leu Glu His Val Asp Gln His Leu Phe Thr Leu Pro Gln Gly Tyr Gly 
65                  70                  75                  80  


Gln Phe Ala Phe Gly Ile Phe Asp Asp Ser Phe Glu Ile Pro Thr Phe 
                85                  90                  95      


Pro Pro Gly Ala Gln Ala Asp Asp Gly Arg Asp Pro Glu Ser Arg Arg 
            100                 105                 110         


Glu Arg Asp His Pro Ser Arg His Arg Tyr Gly Ala Arg Gln Pro Arg 
        115                 120                 125             


Ala Arg Leu Thr Thr Arg Arg Ala Thr Gly Arg His Glu Gly Val Pro 
    130                 135                 140                 


Thr Leu Glu Gly Ile Ile Gln Gln Leu Val Asn Gly Ile Ile Thr Pro 
145                 150                 155                 160 


Ala Thr Ile Pro Ser Leu Gly Pro Trp Gly Val Leu His Ser Asn Pro 
                165                 170                 175     


Met Asp Tyr Ala Trp Gly Ala Asn Gly Leu Asp Ala Ile Ile Thr Gln 
            180                 185                 190         


Leu Leu Asn Gln Phe Glu Asn Thr Gly Pro Pro Pro Ala Asp Lys Glu 
        195                 200                 205             


Lys Ile Gln Ala Leu Pro Thr Val Pro Val Thr Glu Glu His Val Gly 
    210                 215                 220                 


Ser Gly Leu Glu Cys Pro Val Cys Lys Asp Asp Tyr Ala Leu Gly Glu 
225                 230                 235                 240 


Arg Val Arg Gln Leu Pro Cys Asn His Leu Phe His Asp Gly Cys Ile 
                245                 250                 255     


Val Pro Trp Leu Glu Gln His Asp Ser Cys Pro Val Cys Arg Lys Ser 
            260                 265                 270         


Leu Thr Gly Gln Asn Thr Ala Thr Asn Pro Pro Gly Leu Thr Gly Val 
        275                 280                 285             


Ser Phe Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Ser Asn 
    290                 295                 300                 


Glu Asn Ala Thr Trp Ser Pro Leu Gly Arg Pro Gln Pro Pro Arg Pro 
305                 310                 315                 320 


Leu Ser Asn Leu Thr Leu 
                325     


<210>  3650
<211>  1658
<212>  DNA
<213>  Homosapiens

<400>  3650
gccgtgcgtg agcgtgcgcg ggcgcgtcgg ccggcgaggg agcagcaaac ggccggcggc     60

gggtgccgcg cggggggcgg gcggcgcgga gtaggtggcg gcggccatgg ccgaggcgtc    120

gccgcatccc ggacggtact tctgccactg ctgctccgtg gagatcgtcc cgcgcctgcc    180

ggattatatc tgtccaagat gcgagtctgg ttttatcgag gagcttccgg aagagaccag    240

gagcacagaa aatggttctg ccccctccac agctcccaca gaccagagcc ggccaccgtt    300

ggagcacgtg gaccagcacc tgttcacgct gccgcagggc tacggacagt ttgctttcgg    360

catcttcgat gacagcttcg agatccccac gttccctcct ggggcgcagg ctgacgacgg    420

cagggaccct gagagccggc gggagagaga ccatccgtcc cggcaccggt acggcgcccg    480

acagccccgc gcccgcctca ccacgcggcg ggccaccggc cggcacgaag gcgtccccac    540

gctggaaggg atcatccagc agctcgtcaa cggcatcatc acgcccgcca ccatccccag    600

cctgggcccc tggggagtcc tgcactcaaa ccctatggac tacgcctggg gggccaacgg    660

cctggatgcc atcatcacac agctcctcaa tcagtttgaa aacacaggcc ccccaccggc    720

agataaagag aaaatccagg ccctccccac cgtccccgtc actgaggagc acgtaggctc    780

cgggctcgag tgccctgtgt gcaaggacga ctacgcgctg ggtgagcgtg tgcggcagct    840

gccctgcaac cacctgttcc acgacggctg catcgtgccc tggctggagc agcacgacag    900

ctgccccgtc tgccgaaaaa gcctcacggg acagaacacg gccacgaacc cccctggcct    960

cactggggtg agcttctcct cctcgtcgtc atcgtcctcc tccagctcgc ccagcaacga   1020

gaacgccaca agcaactcgt gagcccacgt cggccgtcgg gaaagcacgg ggcctttccc   1080

acccaccctc agccagcgcc acacggcacc cacagactgg gtgccccggc ggcgccacgc   1140

ttggctggtc agcgctgcag gtcccgcctg ttccagggca ggacccgggc ccggcccacc   1200

ggccccctgg cttgggaagg cgtgggccac atggtcccct ctggggcgtc cccagcctcc   1260

ccgtcctctg tctaacctca ccctctaaac gttcagcggt ggaaagattt ttataatttt   1320

aaattattac tgctttgaaa taaacggacg tttgagctca cgtggcggcc atgcatggtt   1380

tgtggcggaa gacggggccc agcggctccc ccagcgctga agcacggggt tcagcggctc   1440

ccccagtgct gcaggtgccg ccaggacggg ccacgtgggc ccccagcctc cccctcggcc   1500

gcctccacga cccggagtag gggggctcgg gaccatgagg atgaccagca aaattcaaga   1560

acaaaactgc tccaacagac ttttttaaag gaaaaaatat gtgtatcttg aaagctattt   1620

aaaatacact acttacaaag agaaaaaaaa aaaaaaaa                           1658


<210>  3651
<211>  311
<212>  PRT
<213>  Homosapiens

<400>  3651

Met Ala Glu Ala Ser Pro His Pro Gly Arg Tyr Phe Cys His Cys Cys 
1               5                   10                  15      


Ser Val Glu Ile Val Pro Arg Leu Pro Asp Tyr Ile Cys Pro Arg Cys 
            20                  25                  30          


Glu Ser Gly Phe Ile Glu Glu Leu Pro Glu Glu Thr Arg Ser Thr Glu 
        35                  40                  45              


Asn Gly Ser Ala Pro Ser Thr Ala Pro Thr Asp Gln Ser Arg Pro Pro 
    50                  55                  60                  


Leu Glu His Val Asp Gln His Leu Phe Thr Leu Pro Gln Gly Tyr Gly 
65                  70                  75                  80  


Gln Phe Ala Phe Gly Ile Phe Asp Asp Ser Phe Glu Ile Pro Thr Phe 
                85                  90                  95      


Pro Pro Gly Ala Gln Ala Asp Asp Gly Arg Asp Pro Glu Ser Arg Arg 
            100                 105                 110         


Glu Arg Asp His Pro Ser Arg His Arg Tyr Gly Ala Arg Gln Pro Arg 
        115                 120                 125             


Ala Arg Leu Thr Thr Arg Arg Ala Thr Gly Arg His Glu Gly Val Pro 
    130                 135                 140                 


Thr Leu Glu Gly Ile Ile Gln Gln Leu Val Asn Gly Ile Ile Thr Pro 
145                 150                 155                 160 


Ala Thr Ile Pro Ser Leu Gly Pro Trp Gly Val Leu His Ser Asn Pro 
                165                 170                 175     


Met Asp Tyr Ala Trp Gly Ala Asn Gly Leu Asp Ala Ile Ile Thr Gln 
            180                 185                 190         


Leu Leu Asn Gln Phe Glu Asn Thr Gly Pro Pro Pro Ala Asp Lys Glu 
        195                 200                 205             


Lys Ile Gln Ala Leu Pro Thr Val Pro Val Thr Glu Glu His Val Gly 
    210                 215                 220                 


Ser Gly Leu Glu Cys Pro Val Cys Lys Asp Asp Tyr Ala Leu Gly Glu 
225                 230                 235                 240 


Arg Val Arg Gln Leu Pro Cys Asn His Leu Phe His Asp Gly Cys Ile 
                245                 250                 255     


Val Pro Trp Leu Glu Gln His Asp Ser Cys Pro Val Cys Arg Lys Ser 
            260                 265                 270         


Leu Thr Gly Gln Asn Thr Ala Thr Asn Pro Pro Gly Leu Thr Gly Val 
        275                 280                 285             


Ser Phe Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Ser Asn 
    290                 295                 300                 


Glu Asn Ala Thr Ser Asn Ser 
305                 310     


<210>  3652
<211>  2525
<212>  DNA
<213>  Homosapiens

<400>  3652
gggaagtcgg tgccgctgcc gtctctgcgt tcgccatgcg tcccggggcg ccagggccac     60

tctggcctct gccctggggg gccctggctt gggccgtggg cttcgtgagc tccatgggct    120

cggggaaccc cgcgcccggt ggtgtttgct ggctccagca gggccaggag gccacctgca    180

gcctggtgct ccagactgat gtcacccggg ccgagtgctg tgcctccggc aacattgaca    240

ccgcctggtc caacctcacc cacccgggga acaagatcaa cctcctcggc ttcttgggcc    300

ttgtccactg ccttccctgc aaagattcgt gcgacggcgt ggagtgcggc ccgggcaagg    360

cgtgccgcat gctggggggc cgcccgcgct gcgagtgcgc gcccgactgc tcggggctcc    420

cggcgcggct gcaggtctgc ggctcagacg gcgccaccta ccgcgacgag tgcgagctgc    480

gcgccgcgcg ctgccgcggc cacccggacc tgagcgtcat gtaccggggc cgctgccgca    540

agtcctgtga gcacgtggtg tgcccgcggc cacagtcgtg cgtcgtggac cagacgggca    600

gcgcccactg cgtggtgtgt cgagcggcgc cctgccctgt gccctccagc cccggccagg    660

agctttgcgg caacaacaac gtcacctaca tctcctcgtg ccacatgcgc caggccacct    720

gcttcctggg ccgctccatc ggcgtgcgcc acgcgggcag ctgcgcaggc acccctgagg    780

agccgccagg tggtgagtct gcagaagagg aagagaactt cgtgtgagcc tgcaggacag    840

gcctgggcct ggtgcccgag gccccccatc atcccctgtt atttattgcc acagcagagt    900

ctaatttata tgccacggac actccttaga gcccggattc ggaccacttg gggatcccag    960

aacctccctg acgatatcct ggaaggactg aggaagggag gcctgggggc cggctggtgg   1020

gtgggataga cctgcgttcc ggacactgag cgcctgattt agggcccttc tctaggatgc   1080

cccagcccct accctaagac ctattgccgg ggaggattcc acacttccgc tcctttgggg   1140

ataaacctat taattattgc tactatcaag agggctgggc attctctgct ggtaattcct   1200

gaagaggcat gactgctttt ctcagcccca agcctctagt ctgggtgtgt acggagggtc   1260

tagcctgggt gtgtacggag ggtctagcct gggtgagtac ggagggtcta gcctgggtga   1320

gtacggaggg tctagcctgg gtgagtacgg agggtctagc ctgggtgtgt atggaggatc   1380

tagcctgggt gagtatggag ggtctagcct gggtgagtat ggagggtcta gcctgggtgt   1440

gtatggaggg tctagcctgg gtgagtatgg agggtctagc ctgggtgtgt atggagggtc   1500

tagcctgggt gagtatggag ggtctagcct gggtgtgtac ggagggtcta gtctgagtgc   1560

gtgtggggac ctcagaacac tgtgacctta gcccagcaag ccaggccctt catgaaggcc   1620

aagaaggctg ccaccattcc ctgccagccc aagaactcca gcttccccac tgcctctgtg   1680

tgcccctttg cgtcctgtga aggccattga gaaatgccca gtgtgccccc tgggaaaggg   1740

cacggcctgt gctcctgaca cgggctgtgc ttggccacag aaccacccag cgtctcccct   1800

gctgctgtcc acgtcagttc atgaggcaac gtcgcgtggt ctcagacgtg gagcagccag   1860

cggcagctca gagcagggca ctgtgtccgg cggagccaag tccactctgg gggagctctg   1920

gcggggacca cgggccactg ctcacccact ggccccgagg ggggtgtaga cgccaagact   1980

cacgcatgtg tgacatccgg agtcctggag ccgggtgtcc cagtggcacc actaggtgcc   2040

tgctgcctcc acagtggggt tcacacccag ggctccttgg tcccccacaa cctgccccgg   2100

ccaggcctgc agacccagac tccagccaga cctgcctcac ccaccaatgc agccggggct   2160

ggcgacacca gccaggtgct ggtcttgggc cagttctccc acgacggctc accctcccct   2220

ccatctgcgt tgatgctcag aatcgcctac ctgtgcctgc gtgtaaacca cagcctcaga   2280

ccagctatgg ggagaggaca acacggagga tatccagctt ccccggtctg gggtgaggaa   2340

tgtggggagc ttgggcatcc tcctccagcc tcctccagcc cccaggcagt gccttacctg   2400

tggtgcccag aaaagtgccc ctaggttggt gggtctacag gagcctcagc caggcagccc   2460

accccaccct ggggccctgc ctcaccaagg aaataaagac tcaagccatt taaaaaaaaa   2520

aaaaa                                                               2525


<210>  3653
<211>  263
<212>  PRT
<213>  Homosapiens

<400>  3653

Met Arg Pro Gly Ala Pro Gly Pro Leu Trp Pro Leu Pro Trp Gly Ala 
1               5                   10                  15      


Leu Ala Trp Ala Val Gly Phe Val Ser Ser Met Gly Ser Gly Asn Pro 
            20                  25                  30          


Ala Pro Gly Gly Val Cys Trp Leu Gln Gln Gly Gln Glu Ala Thr Cys 
        35                  40                  45              


Ser Leu Val Leu Gln Thr Asp Val Thr Arg Ala Glu Cys Cys Ala Ser 
    50                  55                  60                  


Gly Asn Ile Asp Thr Ala Trp Ser Asn Leu Thr His Pro Gly Asn Lys 
65                  70                  75                  80  


Ile Asn Leu Leu Gly Phe Leu Gly Leu Val His Cys Leu Pro Cys Lys 
                85                  90                  95      


Asp Ser Cys Asp Gly Val Glu Cys Gly Pro Gly Lys Ala Cys Arg Met 
            100                 105                 110         


Leu Gly Gly Arg Pro Arg Cys Glu Cys Ala Pro Asp Cys Ser Gly Leu 
        115                 120                 125             


Pro Ala Arg Leu Gln Val Cys Gly Ser Asp Gly Ala Thr Tyr Arg Asp 
    130                 135                 140                 


Glu Cys Glu Leu Arg Ala Ala Arg Cys Arg Gly His Pro Asp Leu Ser 
145                 150                 155                 160 


Val Met Tyr Arg Gly Arg Cys Arg Lys Ser Cys Glu His Val Val Cys 
                165                 170                 175     


Pro Arg Pro Gln Ser Cys Val Val Asp Gln Thr Gly Ser Ala His Cys 
            180                 185                 190         


Val Val Cys Arg Ala Ala Pro Cys Pro Val Pro Ser Ser Pro Gly Gln 
        195                 200                 205             


Glu Leu Cys Gly Asn Asn Asn Val Thr Tyr Ile Ser Ser Cys His Met 
    210                 215                 220                 


Arg Gln Ala Thr Cys Phe Leu Gly Arg Ser Ile Gly Val Arg His Ala 
225                 230                 235                 240 


Gly Ser Cys Ala Gly Thr Pro Glu Glu Pro Pro Gly Gly Glu Ser Ala 
                245                 250                 255     


Glu Glu Glu Glu Asn Phe Val 
            260             


<210>  3654
<211>  1114
<212>  DNA
<213>  Homosapiens

<400>  3654
cggacgcgtg ggcggacgcg tgggcggacg cgtgggtctc tgcggggaga cgccagcctg     60

cgtctgccat ggggctcggg ttgaggggct ggggacgtcc tctgctgact gtggccaccg    120

ccctgatgct gcccgtgaag ccccccgcag gctcctgggg ggcccagatc atcgggggcc    180

acgaggtgac cccccactcc aggccctaca tggcatccgt gcgcttcggg ggccaacatc    240

actgcggagg cttcctgctg cgagcccgct gggtggtctc ggccgcccac tgcttcagcc    300

acagagacct ccgcactggc ctggtggtgc tgggcgccca cgtcctgagt actgcggagc    360

ccacccagca ggtgtttggc atcgatgctc tcaccacgca ccccgactac caccccatga    420

cccacgccaa cgacatctgc ctgctgcggc tgaacggctc tgctgtcctg ggccctgcag    480

tggggctgct gaggctgcca gggagaaggg ccaggccccc cacagcgggg acacggtgcc    540

gggtggctgg ctggggcttc gtgtctgact ttgaggagct gccgcctgga ctgatggagg    600

ccaaggtccg agtgctggac ccggacgtct gcaacagctc ctggaagggc cacctgacac    660

ttaccatgct ctgcacccgc agtggggaca gccacagacg gggcttctgc tcggccgact    720

ccggagggcc cctggtgtgc aggaaccggg ctcacggcct cgtttccttc tcgggcctct    780

ggtgcggcga ccccaagacc cccgacgtgt acacgcaggt gtccgccttt gtggcctgga    840

tctgggacgt ggttcggcgg agcagtcccc agcccggccc cctgcctggg accaccaggc    900

ccccaggaga agccgcctga gccacaacct tgcggcatgc aaatgagatg gccgctccag    960

gcctggaatg ttccgtggct gggccccacg ggaagcctga tgttcagggt tggggtggga   1020

cgggcagcgg tggggcacac ccattccaca tgcaaagggc agaagcaaac ccagtaaaat   1080

gttaactgac aaaaaaaaaa aaaaaaaaaa gaaa                               1114


<210>  3655
<211>  283
<212>  PRT
<213>  Homosapiens

<400>  3655

Met Gly Leu Gly Leu Arg Gly Trp Gly Arg Pro Leu Leu Thr Val Ala 
1               5                   10                  15      


Thr Ala Leu Met Leu Pro Val Lys Pro Pro Ala Gly Ser Trp Gly Ala 
            20                  25                  30          


Gln Ile Ile Gly Gly His Glu Val Thr Pro His Ser Arg Pro Tyr Met 
        35                  40                  45              


Ala Ser Val Arg Phe Gly Gly Gln His His Cys Gly Gly Phe Leu Leu 
    50                  55                  60                  


Arg Ala Arg Trp Val Val Ser Ala Ala His Cys Phe Ser His Arg Asp 
65                  70                  75                  80  


Leu Arg Thr Gly Leu Val Val Leu Gly Ala His Val Leu Ser Thr Ala 
                85                  90                  95      


Glu Pro Thr Gln Gln Val Phe Gly Ile Asp Ala Leu Thr Thr His Pro 
            100                 105                 110         


Asp Tyr His Pro Met Thr His Ala Asn Asp Ile Cys Leu Leu Arg Leu 
        115                 120                 125             


Asn Gly Ser Ala Val Leu Gly Pro Ala Val Gly Leu Leu Arg Leu Pro 
    130                 135                 140                 


Gly Arg Arg Ala Arg Pro Pro Thr Ala Gly Thr Arg Cys Arg Val Ala 
145                 150                 155                 160 


Gly Trp Gly Phe Val Ser Asp Phe Glu Glu Leu Pro Pro Gly Leu Met 
                165                 170                 175     


Glu Ala Lys Val Arg Val Leu Asp Pro Asp Val Cys Asn Ser Ser Trp 
            180                 185                 190         


Lys Gly His Leu Thr Leu Thr Met Leu Cys Thr Arg Ser Gly Asp Ser 
        195                 200                 205             


His Arg Arg Gly Phe Cys Ser Ala Asp Ser Gly Gly Pro Leu Val Cys 
    210                 215                 220                 


Arg Asn Arg Ala His Gly Leu Val Ser Phe Ser Gly Leu Trp Cys Gly 
225                 230                 235                 240 


Asp Pro Lys Thr Pro Asp Val Tyr Thr Gln Val Ser Ala Phe Val Ala 
                245                 250                 255     


Trp Ile Trp Asp Val Val Arg Arg Ser Ser Pro Gln Pro Gly Pro Leu 
            260                 265                 270         


Pro Gly Thr Thr Arg Pro Pro Gly Glu Ala Ala 
        275                 280             


<210>  3656
<211>  2758
<212>  DNA
<213>  Homosapiens

<400>  3656
acaataaaca gcagctttgc gcggggcgat gcccgagccg gtgccgccgc ccccgcgccg     60

cgcagccccg gccgccaggc cttagcccgc cccggccccc gccaggccgc gtccccctcc    120

cctcccctcc cccgcgcgcc acccgcgccc gcccccgccc ggcaccgcgg acccacccgg    180

acctcggcgg ggagatggag gtcctggcgg cagagaccac gtcccagcag gagcggctgc    240

aggccatcgc agagaagcgg aagcggcagg cggagatcga gaacaagcgc cggcagctgg    300

aggacgagcg gaggcagctg cagcacctga agtccaaggc actgcgggag cgctggctgc    360

tggaggggac gccgtcctcg gcctcagagg gggatgagga cctgaggagg cagatgcagg    420

acgacgagca gaagacacgg ctgctggagg actcggtgtc caggttggag aaggaaattg    480

aggtgctgga gcgtggagac tccgccccag ccactgccaa ggagaacgcg gcggccccga    540

gcccagtccg ggccccagcc ccgagtccag ccaaggagga gcgcaagaca gaggtggtga    600

tgaattcaca gcagacgccg gtgggcacgc ccaaagacaa gcgagtctcc aacacgcccc    660

tgaggacggt tgacggctcc cccatgatga aggcagtggt ccatgctgtg gacggcaccg    720

ccgagaacgg gatccacccc ctgagctcct ccgaggtgga cgaactcatc cacaaagcgg    780

acgaggtcac gctgagcgag gcagggtcca cggccggggc ggcagagacc cggggggctg    840

tggagggggc agcccggacc acgccctccc ggcgggagat caccggtgtg caggcacagc    900

caggcgaggc cacgtccggc ccgccgggga tccagcccgg ccaggagccc ccggtcacaa    960

tgatcttcat gggttaccag aacgtggagg atgaggccga gaccaagaag gtgctgggcc   1020

ttcaagatac catcacggcg gagctggtgg tcatcgaaga cgcggctgag cccaaggagc   1080

ctgcaccacc caacggcagt gctgccgagc ctcccacgga ggccgcctcc agggaagaga   1140

atcaggcggg gcccgaggcc accaccagcg acccccagga cctcgacatg aagaagcacc   1200

gttgtaaatg ctgctccatc atgtgagccg gcccccgaga ccccggcccc caccccacac   1260

cacagacacc caccagcccg gcccctcccg gcgcctgccc accctccacc cacagcctca   1320

cgggtccagg acttggcgtg ttgttacatg ttccttccga gttttctttc gctggaaaga   1380

gggacagggg cccccacccg tcaccacgcc ccaacactcc ccccgaacca gagccgtgca   1440

cttgtgcctg gtaggagaga gacaggacag acccgctttt cccgagacaa ggacccccca   1500

tgtcacggca gcttcacaga cgcggctcgc gcccaccggg gtcctggcgg gtgggacccg   1560

cagcctccac gcggcccagg ccagcctgcc accctctggg cctcctacct gtgcctttct   1620

ctgaggggac accccgccag agagggcccc gggagccggg ggtgggtact gaggcctgct   1680

caggccctgg aagtgaggct ctatggggtt ccctggccaa ggcgctggcc ccccaatctc   1740

aggcagttgg ggtgaggccg tgcctctttg ggggctaaag gtcttgggtg gaggacaggc   1800

ccctctgctg tgcccctatg ccctgtgtgg gcccaaccag tggacaatgg agtctggggg   1860

agggggaacc ccggggacat gcccccaccc gggaggggcc ggtaacccct gggctatctt   1920

ctagacgggg cgaaccaggg gtcattgacc tgccccctgc acagggcagg gaccgagtga   1980

gccactcctt gtcccgagct cccgccccca ctgggccctc cttcctcctg gtgctaattt   2040

ggggacccca ggggccgccc ccggcctctt ctccatcctg cttggaccag ggtcctgggt   2100

cttcccaacc ataccccgag atcaggcccc acctgccagc tctactgggc ttggagcacg   2160

tccgggcagt ggagggaggg acacagcctg ggacaggaag cctcttgggt tggagcagga   2220

gaccctcatt tgccacccag accaatgtga gcctgccccc agccccctct cattggaagt   2280

ggcaaggggc ttccctcctg ggggcagcta cactcgtccc cagaggcaca ttcgtgcaca   2340

ttctcacaga caccgtctca cacgttggct ttggacaacc aggccccaac ttggtccctg   2400

ccctagggac ctccagcctg gtgcccagtg ctcaggccac ctcctggtcc agtcaccacc   2460

tgcagcctcg gcagggcagg tacaggggcc acctcggatg ggagcctggg tccctgcctc   2520

cgctctgccc ctgggtggct gggaggagag gccctctcgg gggtgacctg ggcgtcagcc   2580

gtggaacccc ctcctcctcc ctggagtctg cctgagtccc tcgagccgcg agccttcgct   2640

gaagtgccct tgctataacc ccctctgctt ctggtgtgtg acgaggcccc cgatgttctt   2700

gattttccca gagaagcaaa taaacagcgt gaacagcccc agaaaaaaaa aaaaaaaa     2758


<210>  3657
<211>  343
<212>  PRT
<213>  Homosapiens

<400>  3657

Met Glu Val Leu Ala Ala Glu Thr Thr Ser Gln Gln Glu Arg Leu Gln 
1               5                   10                  15      


Ala Ile Ala Glu Lys Arg Lys Arg Gln Ala Glu Ile Glu Asn Lys Arg 
            20                  25                  30          


Arg Gln Leu Glu Asp Glu Arg Arg Gln Leu Gln His Leu Lys Ser Lys 
        35                  40                  45              


Ala Leu Arg Glu Arg Trp Leu Leu Glu Gly Thr Pro Ser Ser Ala Ser 
    50                  55                  60                  


Glu Gly Asp Glu Asp Leu Arg Arg Gln Met Gln Asp Asp Glu Gln Lys 
65                  70                  75                  80  


Thr Arg Leu Leu Glu Asp Ser Val Ser Arg Leu Glu Lys Glu Ile Glu 
                85                  90                  95      


Val Leu Glu Arg Gly Asp Ser Ala Pro Ala Thr Ala Lys Glu Asn Ala 
            100                 105                 110         


Ala Ala Pro Ser Pro Val Arg Ala Pro Ala Pro Ser Pro Ala Lys Glu 
        115                 120                 125             


Glu Arg Lys Thr Glu Val Val Met Asn Ser Gln Gln Thr Pro Val Gly 
    130                 135                 140                 


Thr Pro Lys Asp Lys Arg Val Ser Asn Thr Pro Leu Arg Thr Val Asp 
145                 150                 155                 160 


Gly Ser Pro Met Met Lys Ala Val Val His Ala Val Asp Gly Thr Ala 
                165                 170                 175     


Glu Asn Gly Ile His Pro Leu Ser Ser Ser Glu Val Asp Glu Leu Ile 
            180                 185                 190         


His Lys Ala Asp Glu Val Thr Leu Ser Glu Ala Gly Ser Thr Ala Gly 
        195                 200                 205             


Ala Ala Glu Thr Arg Gly Ala Val Glu Gly Ala Ala Arg Thr Thr Pro 
    210                 215                 220                 


Ser Arg Arg Glu Ile Thr Gly Val Gln Ala Gln Pro Gly Glu Ala Thr 
225                 230                 235                 240 


Ser Gly Pro Pro Gly Ile Gln Pro Gly Gln Glu Pro Pro Val Thr Met 
                245                 250                 255     


Ile Phe Met Gly Tyr Gln Asn Val Glu Asp Glu Ala Glu Thr Lys Lys 
            260                 265                 270         


Val Leu Gly Leu Gln Asp Thr Ile Thr Ala Glu Leu Val Val Ile Glu 
        275                 280                 285             


Asp Ala Ala Glu Pro Lys Glu Pro Ala Pro Pro Asn Gly Ser Ala Ala 
    290                 295                 300                 


Glu Pro Pro Thr Glu Ala Ala Ser Arg Glu Glu Asn Gln Ala Gly Pro 
305                 310                 315                 320 


Glu Ala Thr Thr Ser Asp Pro Gln Asp Leu Asp Met Lys Lys His Arg 
                325                 330                 335     


Cys Lys Cys Cys Ser Ile Met 
            340             


<210>  3658
<211>  2890
<212>  DNA
<213>  Homosapiens

<400>  3658
acaataaaca gcagctttgc gcggggcgat gcccgagccg gtgccgccgc ccccgcgccg     60

cgcagccccg gccgccaggc cttagcccgc cccggccccc gccaggccgc gtccccctcc    120

cctcccctcc cccgcgcgcc acccgcgccc gcccccgccc ggcaccgcgg acccacccgg    180

acctcggcgg ggagatggag gtcctggcgg cagagaccac gtcccagcag gagcggctgc    240

aggccatcgc agagaagcgg aagcggcagg cggagatcga gaacaagcgc cggcagctgg    300

aggacgagcg gaggcagctg cagcacctga agtccaaggc actgcgggag cgctggctgc    360

tggaggggac gccgtcctcg gcctcagagg gggatgagga cctgaggagg cagatgcagg    420

acgacgagca gaagacacgg ctgctggagg actcggtgtc caggttggag aaggaaattg    480

aggtgctgga gcgtggagac tccgccccag ccactgccaa ggagaacgcg gcggccccga    540

gcccagtccg ggccccagcc ccgagtccag ccaaggagga gcgcaagaca gaggtggtga    600

tgaattcaca gcagacgccg gtgggcacgc ccaaagacaa gcgagtctcc aacacgcccc    660

tgaggacggt tgacggctcc cccatgatga aggcagccat gtactcggtt gagatcactg    720

tggagaagga caaggtgaca ggggagacca gggtgctgtc cagcaccacg ctgctccctc    780

ggcagccgct ccctctgggc atcaaagtct acgaggacga gaccaaagtg gtccatgctg    840

tggacggcac cgccgagaac gggatccacc ccctgagctc ctccgaggtg gacgaactca    900

tccacaaagc ggacgaggtc acgctgagcg aggcagggtc cacggccggg gcggcagaga    960

cccggggggc tgtggagggg gcagcccgga ccacgccctc ccggcgggag atcaccggtg   1020

tgcaggcaca gccaggcgag gccacgtccg gcccgccggg gatccagccc ggccaggagc   1080

ccccggtcac aatgatcttc atgggttacc agaacgtgga ggatgaggcc gagaccaaga   1140

aggtgctggg ccttcaagat accatcacgg cggagctggt ggtcatcgaa gacgcggctg   1200

agcccaagga gcctgcacca cccaacggca gtgctgccga gcctcccacg gaggccgcct   1260

ccagggaaga gaatcaggcg gggcccgagg ccaccaccag cgacccccag gacctcgaca   1320

tgaagaagca ccgttgtaaa tgctgctcca tcatgtgagc cggcccccga gaccccggcc   1380

cccaccccac accacagaca cccaccagcc cggcccctcc cggcgcctgc ccaccctcca   1440

cccacagcct cacgggtcca ggacttggcg tgttgttaca tgttccttcc gagttttctt   1500

tcgctggaaa gagggacagg ggcccccacc cgtcaccacg ccccaacact ccccccgaac   1560

cagagccgtg cacttgtgcc tggtaggaga gagacaggac agacccgctt ttcccgagac   1620

aaggaccccc catgtcacgg cagcttcaca gacgcggctc gcgcccaccg gggtcctggc   1680

gggtgggacc cgcagcctcc acgcggccca ggccagcctg ccaccctctg ggcctcctac   1740

ctgtgccttt ctctgagggg acaccccgcc agagagggcc ccgggagccg ggggtgggta   1800

ctgaggcctg ctcaggccct ggaagtgagg ctctatgggg ttccctggcc aaggcgctgg   1860

ccccccaatc tcaggcagtt ggggtgaggc cgtgcctctt tgggggctaa aggtcttggg   1920

tggaggacag gcccctctgc tgtgccccta tgccctgtgt gggcccaacc agtggacaat   1980

ggagtctggg ggagggggaa ccccggggac atgcccccac ccgggagggg ccggtaaccc   2040

ctgggctatc ttctagacgg ggcgaaccag gggtcattga cctgccccct gcacagggca   2100

gggaccgagt gagccactcc ttgtcccgag ctcccgcccc cactgggccc tccttcctcc   2160

tggtgctaat ttggggaccc caggggccgc ccccggcctc ttctccatcc tgcttggacc   2220

agggtcctgg gtcttcccaa ccataccccg agatcaggcc ccacctgcca gctctactgg   2280

gcttggagca cgtccgggca gtggagggag ggacacagcc tgggacagga agcctcttgg   2340

gttggagcag gagaccctca tttgccaccc agaccaatgt gagcctgccc ccagccccct   2400

ctcattggaa gtggcaaggg gcttccctcc tgggggcagc tacactcgtc cccagaggca   2460

cattcgtgca cattctcaca gacaccgtct cacacgttgg ctttggacaa ccaggcccca   2520

acttggtccc tgccctaggg acctccagcc tggtgcccag tgctcaggcc acctcctggt   2580

ccagtcacca cctgcagcct cggcagggca ggtacagggg ccacctcgga tgggagcctg   2640

ggtccctgcc tccgctctgc ccctgggtgg ctgggaggag aggccctctc gggggtgacc   2700

tgggcgtcag ccgtggaacc ccctcctcct ccctggagtc tgcctgagtc cctcgagccg   2760

cgagccttcg ctgaagtgcc cttgctataa ccccctctgc ttctggtgtg tgacgaggcc   2820

cccgatgttc ttgattttcc cagagaagca aataaacagc gtgaacagcc ccagaaaaaa   2880

aaaaaaaaaa                                                          2890


<210>  3659
<211>  387
<212>  PRT
<213>  Homosapiens

<400>  3659

Met Glu Val Leu Ala Ala Glu Thr Thr Ser Gln Gln Glu Arg Leu Gln 
1               5                   10                  15      


Ala Ile Ala Glu Lys Arg Lys Arg Gln Ala Glu Ile Glu Asn Lys Arg 
            20                  25                  30          


Arg Gln Leu Glu Asp Glu Arg Arg Gln Leu Gln His Leu Lys Ser Lys 
        35                  40                  45              


Ala Leu Arg Glu Arg Trp Leu Leu Glu Gly Thr Pro Ser Ser Ala Ser 
    50                  55                  60                  


Glu Gly Asp Glu Asp Leu Arg Arg Gln Met Gln Asp Asp Glu Gln Lys 
65                  70                  75                  80  


Thr Arg Leu Leu Glu Asp Ser Val Ser Arg Leu Glu Lys Glu Ile Glu 
                85                  90                  95      


Val Leu Glu Arg Gly Asp Ser Ala Pro Ala Thr Ala Lys Glu Asn Ala 
            100                 105                 110         


Ala Ala Pro Ser Pro Val Arg Ala Pro Ala Pro Ser Pro Ala Lys Glu 
        115                 120                 125             


Glu Arg Lys Thr Glu Val Val Met Asn Ser Gln Gln Thr Pro Val Gly 
    130                 135                 140                 


Thr Pro Lys Asp Lys Arg Val Ser Asn Thr Pro Leu Arg Thr Val Asp 
145                 150                 155                 160 


Gly Ser Pro Met Met Lys Ala Ala Met Tyr Ser Val Glu Ile Thr Val 
                165                 170                 175     


Glu Lys Asp Lys Val Thr Gly Glu Thr Arg Val Leu Ser Ser Thr Thr 
            180                 185                 190         


Leu Leu Pro Arg Gln Pro Leu Pro Leu Gly Ile Lys Val Tyr Glu Asp 
        195                 200                 205             


Glu Thr Lys Val Val His Ala Val Asp Gly Thr Ala Glu Asn Gly Ile 
    210                 215                 220                 


His Pro Leu Ser Ser Ser Glu Val Asp Glu Leu Ile His Lys Ala Asp 
225                 230                 235                 240 


Glu Val Thr Leu Ser Glu Ala Gly Ser Thr Ala Gly Ala Ala Glu Thr 
                245                 250                 255     


Arg Gly Ala Val Glu Gly Ala Ala Arg Thr Thr Pro Ser Arg Arg Glu 
            260                 265                 270         


Ile Thr Gly Val Gln Ala Gln Pro Gly Glu Ala Thr Ser Gly Pro Pro 
        275                 280                 285             


Gly Ile Gln Pro Gly Gln Glu Pro Pro Val Thr Met Ile Phe Met Gly 
    290                 295                 300                 


Tyr Gln Asn Val Glu Asp Glu Ala Glu Thr Lys Lys Val Leu Gly Leu 
305                 310                 315                 320 


Gln Asp Thr Ile Thr Ala Glu Leu Val Val Ile Glu Asp Ala Ala Glu 
                325                 330                 335     


Pro Lys Glu Pro Ala Pro Pro Asn Gly Ser Ala Ala Glu Pro Pro Thr 
            340                 345                 350         


Glu Ala Ala Ser Arg Glu Glu Asn Gln Ala Gly Pro Glu Ala Thr Thr 
        355                 360                 365             


Ser Asp Pro Gln Asp Leu Asp Met Lys Lys His Arg Cys Lys Cys Cys 
    370                 375                 380                 


Ser Ile Met 
385         


<210>  3660
<211>  1491
<212>  DNA
<213>  Homosapiens

<400>  3660
cgagactcca tctcaaaaac aaaacaaata aacgaacaaa aaaacccaca acgtattatt     60

ttcttgttta cgaggtttct tgtctctctg gctccaccag aagaggagca gggacccttc    120

ttgctgttgt tcattgctgc atcccccaca ccgagagcag agcctggcat gggcagaaag    180

tcctcagtcg atatttggtg gccccaagcg aatgaagcat ccaagaaggg aaagctgggg    240

gctccccact gcacttgcca cctgagtcac attttcagaa gcctctggaa agtcgtgcac    300

agcccaggag tgttgagcaa tttcggtttc ctctgaggtt gaaggaccca ggcgtgtcag    360

ccctgctcca gacaccttgg gcatggagga gagtgtcgta cggccctcag tgtttgtggt    420

ggatggacag accgacatcc cattcacgag gctgggacga agccaccgga gacagtcgtg    480

cagtgtggcc cgggtgggtc tgggtctctt gctgttgctg atgggggccg ggctggccgt    540

ccaaggctgg ttcctcctgc agctgcactg gcgtctagga gagatggtca cccgcctgcc    600

tgacggacct gcaggctcct gggagcagct gatacaagag cgaaggtctc acgaggtcaa    660

cccagcagcg catctcacag gggccaactc cagcttgacc ggcagcgggg ggccgctgtt    720

atgggagact cagctgggcc tggccttcct gaggggcctc agctaccacg atggggccct    780

tgtggtcacc aaagctggct actactacat ctactccaag gtgcagctgg gcggtgtggg    840

ctgcccgctg ggcctggcca gcaccatcac ccacggcctc tacaagcgca caccccgcta    900

ccccgaggag ctggagctgt tggtcagcca gcagtcaccc tgcggacggg ccaccagcag    960

ctcccgggtc tggtgggaca gcagcttcct gggtggtgtg gtacacctgg aggctgggga   1020

gaaggtggtc gtccgtgtgc tggatgaacg cctggttcga ctgcgtgatg gtacccggtc   1080

ttacttcggg gctttcatgg tgtgaaggaa ggagcgtggt gcattggaca tgggtctgac   1140

acgtggagaa ctcagagggt gcctcagggg aaagaaaact cacgaagcag aggctgggcg   1200

tggtggctct cgcctgtaat cccagcactt tgggaggcca aggcaggcgg atcacctgag   1260

gtcaggagtt cgagaccagc ctggctaaca tggcaaaacc ccatctctac taaaaataca   1320

aaaattagcc ggacgtggtg gtgcctgcct gtaatccagc tactcaggag gctgaggcag   1380

gataattttg cttaaacccg ggaggcggag gttgcagtga gccgagatca caccactgca   1440

ctccaacctg ggaaacgcag tgagactgtg cctcaaaaaa aaaaaaaaaa a            1491


<210>  3661
<211>  240
<212>  PRT
<213>  Homosapiens

<400>  3661

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  3662
<211>  1395
<212>  DNA
<213>  Homosapiens

<400>  3662
cgagactcca tctcaaaaac aaaacaaata aacgaacaaa aaaacccaca acgtattatt     60

ttcttgttta cgaggtttct tgtctctctg gctccaccag aagaggagca gggacccttc    120

ttgctgttgt tcattgctgc atcccccaca ccgagagcag agcctggcat gggcagaaag    180

tcctcagtcg atatttggtg gccccaagcg aatgaagcat ccaagaaggg aaagctgggg    240

gctccccact gcacttgcca cctgagtcac attttcagaa gcctctggaa agtcgtgcac    300

agcccaggag tgttgagcaa tttcggtttc ctctgaggtt gaaggaccca ggcgtgtcag    360

ccctgctcca gacaccttgg gcatggagga gagtgtcgta cggccctcag tgtttgtggt    420

ggatggacag accgacatcc cattcacgag gctgggacga agccaccgga gacagtcgtg    480

cagtgtggcc cgggacggac ctgcaggctc ctgggagcag ctgatacaag agcgaaggtc    540

tcacgaggtc aacccagcag cgcatctcac aggggccaac tccagcttga ccggcagcgg    600

ggggccgctg ttatgggaga ctcagctggg cctggccttc ctgaggggcc tcagctacca    660

cgatggggcc cttgtggtca ccaaagctgg ctactactac atctactcca aggtgcagct    720

gggcggtgtg ggctgcccgc tgggcctggc cagcaccatc acccacggcc tctacaagcg    780

cacaccccgc taccccgagg agctggagct gttggtcagc cagcagtcac cctgcggacg    840

ggccaccagc agctcccggg tctggtggga cagcagcttc ctgggtggtg tggtacacct    900

ggaggctggg gaggaggtgg tcgtccgtgt gctggatgaa cgcctggttc gactgcgtga    960

tggtacccgg tcttacttcg gggctttcat ggtgtgaagg aaggagcgtg gtgcattgga   1020

catgggtctg acacgtggag aactcagagg gtgcctcagg ggaaagaaaa ctcacgaagc   1080

agaggctggg cgtggtggct ctcgcctgta atcccagcac tttgggaggc caaggcaggc   1140

ggatcacctg aggtcaggag ttcgagacca gcctggctaa catggcaaaa ccccatctct   1200

actaaaaata caaaaattag ccggacgtgg tggtgcctgc ctgtaatcca gctactcagg   1260

aggctgaggc aggataattt tgcttaaacc cgggaggcgg aggttgcagt gagccgagat   1320

cacaccactg cactccaacc tgggaaacgc agtgagactg tgcctcaaaa aaaaaaaaaa   1380

aaaaaaaaaa aaaaa                                                    1395


<210>  3663
<211>  204
<212>  PRT
<213>  Homosapiens

<400>  3663

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Asp Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile 
        35                  40                  45              


Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly 
    50                  55                  60                  


Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
65                  70                  75                  80  


Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
                85                  90                  95      


Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
            100                 105                 110         


Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
        115                 120                 125             


Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
    130                 135                 140                 


Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
145                 150                 155                 160 


Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
                165                 170                 175     


Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
            180                 185                 190         


Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
        195                 200                 


<210>  3664
<211>  5067
<212>  DNA
<213>  Homosapiens

<400>  3664
ctcctcccca tcctctccct ctgtccctct gtccctctga ccctgcactg tcccagcacc     60

atgggaccca cctcaggtcc cagcctgctg ctcctgctac taacccacct ccccctggct    120

ctggggagtc ccatgtactc tatcatcacc cccaacatct tgcggctgga gagcgaggag    180

accatggtgc tggaggccca cgacgcgcaa ggggatgttc cagtcactgt tactgtccac    240

gacttcccag gcaaaaaact agtgctgtcc agtgagaaga ctgtgctgac ccctgccacc    300

aaccacatgg gcaacgtcac cttcacgatc ccagccaaca gggagttcaa gtcagaaaag    360

gggcgcaaca agttcgtgac cgtgcaggcc accttcggga cccaagtggt ggagaaggtg    420

gtgctggtca gcctgcagag cgggtacctc ttcatccaga cagacaagac catctacacc    480

cctggctcca cagttctcta tcggatcttc accgtcaacc acaagctgct acccgtgggc    540

cggacggtca tggtcaacat tgagaacccg gaaggcatcc cggtcaagca ggactccttg    600

tcttctcaga accagcttgg cgtcttgccc ttgtcttggg acattccgga actcgtcaac    660

atgggccagt ggaagatccg agcctactat gaaaactcac cacagcaggt cttctccact    720

gagtttgagg tgaaggagta cgtgctgccc agtttcgagg tcatagtgga gcctacagag    780

aaattctact acatctataa cgagaagggc ctggaggtca ccatcaccgc caggttcctc    840

tacgggaaga aagtggaggg aactgccttt gtcatcttcg ggatccagga tggcgaacag    900

aggatttccc tgcctgaatc cctcaagcgc attccgattg aggatggctc gggggaggtt    960

gtgctgagcc ggaaggtact gctggacggg gtgcagaacc tccgagcaga agacctggtg   1020

gggaagtctt tgtacgtgtc tgccaccgtc atcttgcact caggcagtga catggtgcag   1080

gcagagcgca gcgggatccc catcgtgacc tctccctacc agatccactt caccaagaca   1140

cccaagtact tcaaaccagg aatgcccttt gacctcatgg tgttcgtgac gaaccctgat   1200

ggctctccag cctaccgagt ccccgtggca gtccagggcg aggacactgt gcagtctcta   1260

acccagggag atggcgtggc caaactcagc atcaacacac accccagcca gaagcccttg   1320

agcatcacgg tgcgcacgaa gaagcaggag ctctcggagg cagagcaggc taccaggacc   1380

atgcaggctc tgccctacag caccgtgggc aactccaaca attacctgca tctctcagtg   1440

ctacgtacag agctcagacc cggggagacc ctcaacgtca acttcctcct gcgaatggac   1500

cgcgcccacg aggccaagat ccgctactac acctacctga tcatgaacaa gggcaggctg   1560

ttgaaggcgg gacgccaggt gcgagagccc ggccaggacc tggtggtgct gcccctgtcc   1620

atcaccaccg acttcatccc ttccttccgc ctggtggcgt actacacgct gatcggtgcc   1680

agcggccaga gggaggtggt ggccgactcc gtgtgggtgg acgtcaagga ctcctgcgtg   1740

ggctcgctgg tggtaaaaag cggccagtca gaagaccggc agcctgtacc tgggcagcag   1800

atgaccctga agatagaggg tgaccacggg gcccgggtgg tactggtggc cgtggacaag   1860

ggcgtgttcg tgctgaataa gaagaacaaa ctgacgcaga gtaagatctg ggacgtggtg   1920

gagaaggcag acatcggctg caccccgggc agtgggaagg attacgccgg tgtcttctcc   1980

gacgcagggc tgaccttcac gagcagcagt ggccagcaga ccgcccagag ggcagaactt   2040

cagtgcccgc agccagccgc ccgccgacgc cgttccgtgc agctcacgga gaagcgaatg   2100

gacaaagtcg gcaagtaccc caaggagctg cgcaagtgct gcgaggacgg catgcgggag   2160

aaccccatga ggttctcgtg ccagcgccgg acccgtttca tctccctggg cgaggcgtgc   2220

aagaaggtct tcctggactg ctgcaactac atcacagagc tgcggcggca gcacgcgcgg   2280

gccagccacc tgggcctggc caggagtaac ctggatgagg acatcattgc agaagagaac   2340

atcgtttccc gaagtgagtt cccagagagc tggctgtgga acgttgagga cttgaaagag   2400

ccaccgaaaa atggaatctc tacgaagctc atgaatatat ttttgaaaga ctccatcacc   2460

acgtgggaga ttctggctgt cagcatgtcg gacaagaaag ggatctgtgt ggcagacccc   2520

ttcgaggtca cagtaatgca ggacttcttc atcgacctgc ggctacccta ctctgttgtt   2580

cgaaacgagc aggtggaaat ccgagccgtt ctctacaatt accggcagaa ccaagagctc   2640

aaggtgaggg tggaactact ccacaatcca gccttctgca gcctggccac caccaagagg   2700

cgtcaccagc agaccgtaac catccccccc aagtcctcgt tgtccgttcc atatgtcatc   2760

gtgccgctaa agaccggcct gcaggaagtg gaagtcaagg ctgccgtcta ccatcatttc   2820

atcagtgacg gtgtcaggaa gtccctgaag gtcgtgccgg aaggaatcag aatgaacaaa   2880

actgtggctg ttcgcaccct ggatccagaa cgcctgggcc gtgaaggagt gcagaaagag   2940

gacatcccac ctgcagacct cagtgaccaa gtcccggaca ccgagtctga gaccagaatt   3000

ctcctgcaag ggaccccagt ggcccagatg acagaggatg ccgtcgacgc ggaacggctg   3060

aagcacctca ttgtgacccc ctcgggctgc ggggaacaga acatgatcgg catgacgccc   3120

acggtcatcg ctgtgcatta cctggatgaa acggagcagt gggagaagtt cggcctagag   3180

aagcggcagg gggccttgga gctcatcaag aaggggtaca cccagcagct ggccttcaga   3240

caacccagct ctgcctttgc ggccttcgtg aaacgggcac ccagcacctg gctgaccgcc   3300

tacgtggtca aggtcttctc tctggctgtc aacctcatcg ccatcgactc ccaagtcctc   3360

tgcggggctg ttaaatggct gatcctggag aagcagaagc ccgacggggt cttccaggag   3420

gatgcgcccg tgatacacca agaaatgatt ggtggattac ggaacaacaa cgagaaagac   3480

atggccctca cggcctttgt tctcatctcg ctgcaggagg ctaaagatat ttgcgaggag   3540

caggtcaaca gcctgccagg cagcatcact aaagcaggag acttccttga agccaactac   3600

atgaacctac agagatccta cactgtggcc attgctggct atgctctggc ccagatgggc   3660

aggctgaagg ggcctcttct taacaaattt ctgaccacag ccaaagataa gaaccgctgg   3720

gaggaccctg gtaagcagct ctacaacgtg gaggccacat cctatgccct cttggcccta   3780

ctgcagctaa aagactttga ctttgtgcct cccgtcgtgc gttggctcaa tgaacagaga   3840

tactacggtg gtggctatgg ctctacccag gccaccttca tggtgttcca agccttggct   3900

caataccaaa aggacgcccc tgaccaccag gaactgaacc ttgatgtgtc cctccaactg   3960

cccagccgca gctccaagat cacccaccgt atccactggg aatctgccag cctcctgcga   4020

tcagaagaga ccaaggaaaa tgagggtttc acagtcacag ctgaaggaaa aggccaaggc   4080

accttgtcgg tggtgacaat gtaccatgct aaggccaaag atcaactcac ctgtaataaa   4140

ttcgacctca aggtcaccat aaaaccagca ccggaaacag aaaagaggcc tcaggatgcc   4200

aagaacacta tgatccttga gatctgtacc aggtaccggg gagaccagga tgccactatg   4260

tctatattgg acatatccat gatgactggc tttgctccag acacagatga cctgaagcag   4320

ctggccaatg gtgttgacag atacatctcc aagtatgagc tggacaaagc cttctccgat   4380

aggaacaccc tcatcatcta cctggacaag gtctcacact ctgaggatga ctgtctagct   4440

ttcaaagttc accaatactt taatgtagag cttatccagc ctggagcagt caaggtctac   4500

gcctattaca acctggagga aagctgtacc cggttctacc atccggaaaa ggaggatgga   4560

aagctgaaca agctctgccg tgatgaactg tgccgctgtg ctgaggagaa ttgcttcata   4620

caaaagtcgg atgacaaggt caccctggaa gaacggctgg acaaggcctg tgagccagga   4680

gtggactatg tgtacaagac ccgactggtc aaggttcagc tgtccaatga ctttgacgag   4740

tacatcatgg ccattgagca gaccatcaag tcaggctcgg atgaggtgca ggttggacag   4800

cagcgcacgt tcatcagccc catcaagtgc agagaagccc tgaagctgga ggagaagaaa   4860

cactacctca tgtggggtct ctcctccgat ttctggggag agaagcccaa cctcagctac   4920

atcatcggga aggacacttg ggtggagcac tggcctgagg aggacgaatg ccaagacgaa   4980

gagaaccaga aacaatgcca ggacctcggc gccttcaccg agagcatggt tgtctttggg   5040

tgccccaact gaccacaccc ccattcc                                       5067


<210>  3665
<211>  1663
<212>  PRT
<213>  Homosapiens

<400>  3665

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Leu Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  3666
<211>  2064
<212>  DNA
<213>  Homosapiens

<400>  3666
gggcgccaga ggcggagtcg gggaggaggt ggctccagag atggcagtga gcgagaggag     60

ggggctcggc cgcgggagcc ccgcggagtg ggggcagcgg ctacttctgg tgctgctgct    120

gggtggctgc tccgggcgca tccaccagct ggcgctgacg ggggagaagc gagcggacat    180

ccagctgaac agcttcggtt tctacaccaa tggctctctg gaggtggagt tgagcgtcct    240

gcggctgggc ctccgggagg cagaagagaa gtccctgctg gtggggttca gtctcagccg    300

ggttcggtct ggcagagttc gctcctattc aacccgggat ttccaggact gccctctcca    360

gaaaaacagt agcagtttcc tggtcctgtt cctcatcaac accaaggatc tgcaggtcca    420

ggtgcggaag tatggagagc agaagacgtt gtttatcttt cccgggctcc tcccggaagc    480

accctccaaa ccagggctcc cgaagccaca ggccacagtc ccccgcaagg tggatggcgg    540

agggacctct gcagccagca agcccaagtc aacacccgca gtgattcagg gtcctagtgg    600

gaaggacaag gacctggtgt tgggcctgag ccacctcaac aactcctaca acttcagttt    660

ccacgtggtg atcggctctc aggcggaaga aggccagtac agcctgaact tccacaactg    720

caacaattca gtgccaggaa aggagcatcc attcgacatc acggtgatga tccgggagaa    780

gaaccccgat ggcttcctgt cggcagcgga gatgcccctt ttcaagctct acatggtcat    840

gtccgcctgc ttcctggccg ctggcatctt ctgggtgtcc atcctctgca ggaacacgta    900

cagcgtcttc aagatccact ggctcatggc ggccttggcc ttcaccaaga gcatctctct    960

cctcttccac agcatcaact actacttcat caacagccag ggccacccca tcgaaggcct   1020

tgccgtcatg tactacatcg cacacctgct gaagggcgcc ctcctcttca tcaccatcgc   1080

cctgattggc tcaggctggg ccttcatcaa gtacgtcctg tcggataagg agaagaaggt   1140

ctttgggatc gtgatcccca tgcaggtcct ggccaacgtg gcctacatca tcatcgagtc   1200

ccgcgaggaa ggcgccagcg actacgtgct gtggaaggag attttgttcc tggtggacct   1260

catctgctgt ggtgccatcc tgttccccgt agtctggtcc atccggcatc tccaggatgc   1320

gtctggcaca gacgggaagg tggcagtgaa cctggccaag ctgaagctgt tccggcatta   1380

ctatgtcatg gtcatctgct acgtctactt cacccgcatc atcgccatcc tgctgcaggt   1440

ggctgtgccc tttcagtggc agtggctgta ccagctcttg gtggagggct ccaccctggc   1500

cttcttcgtg ctcacgggct acaagttcca gcccacagga aacaacccgt acctgcagct   1560

gccccaggag gacgaggagg atgttcagat ggagcaagta atgacggact ctgggttccg   1620

ggaaggcctc tccaaagtca acaaaacagc cagcgggcgg gaactgttat gatcacctcc   1680

acatctcaga ccaaagggtc gtcctccccc agcatttctc actcctgccc ttcttccaca   1740

gcgtatgtgg ggaggtggag ggggtccatg tggaccaggc gcccagctcc ccgggacccc   1800

ggttcccgga caagcccatt tggaagaaga gtcccttcct ccccccaaat attgggcagc   1860

cctgtcctta ccccgggacc acccctccct tccagctatg tgtacaataa tgaccaatct   1920

gtttggctac gccgttgtct tgcctttttg ggggttgggg tctacacgga ggttgtgttt   1980

acaatgtaga aacctgtttt cgctgtgtgt ggcgggggcg cgggcacagg gtccgtgtct   2040

ttgtatattc aataaatatt catt                                          2064


<210>  3667
<211>  543
<212>  PRT
<213>  Homosapiens

<400>  3667

Met Ala Val Ser Glu Arg Arg Gly Leu Gly Arg Gly Ser Pro Ala Glu 
1               5                   10                  15      


Trp Gly Gln Arg Leu Leu Leu Val Leu Leu Leu Gly Gly Cys Ser Gly 
            20                  25                  30          


Arg Ile His Gln Leu Ala Leu Thr Gly Glu Lys Arg Ala Asp Ile Gln 
        35                  40                  45              


Leu Asn Ser Phe Gly Phe Tyr Thr Asn Gly Ser Leu Glu Val Glu Leu 
    50                  55                  60                  


Ser Val Leu Arg Leu Gly Leu Arg Glu Ala Glu Glu Lys Ser Leu Leu 
65                  70                  75                  80  


Val Gly Phe Ser Leu Ser Arg Val Arg Ser Gly Arg Val Arg Ser Tyr 
                85                  90                  95      


Ser Thr Arg Asp Phe Gln Asp Cys Pro Leu Gln Lys Asn Ser Ser Ser 
            100                 105                 110         


Phe Leu Val Leu Phe Leu Ile Asn Thr Lys Asp Leu Gln Val Gln Val 
        115                 120                 125             


Arg Lys Tyr Gly Glu Gln Lys Thr Leu Phe Ile Phe Pro Gly Leu Leu 
    130                 135                 140                 


Pro Glu Ala Pro Ser Lys Pro Gly Leu Pro Lys Pro Gln Ala Thr Val 
145                 150                 155                 160 


Pro Arg Lys Val Asp Gly Gly Gly Thr Ser Ala Ala Ser Lys Pro Lys 
                165                 170                 175     


Ser Thr Pro Ala Val Ile Gln Gly Pro Ser Gly Lys Asp Lys Asp Leu 
            180                 185                 190         


Val Leu Gly Leu Ser His Leu Asn Asn Ser Tyr Asn Phe Ser Phe His 
        195                 200                 205             


Val Val Ile Gly Ser Gln Ala Glu Glu Gly Gln Tyr Ser Leu Asn Phe 
    210                 215                 220                 


His Asn Cys Asn Asn Ser Val Pro Gly Lys Glu His Pro Phe Asp Ile 
225                 230                 235                 240 


Thr Val Met Ile Arg Glu Lys Asn Pro Asp Gly Phe Leu Ser Ala Ala 
                245                 250                 255     


Glu Met Pro Leu Phe Lys Leu Tyr Met Val Met Ser Ala Cys Phe Leu 
            260                 265                 270         


Ala Ala Gly Ile Phe Trp Val Ser Ile Leu Cys Arg Asn Thr Tyr Ser 
        275                 280                 285             


Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Ala Phe Thr Lys Ser 
    290                 295                 300                 


Ile Ser Leu Leu Phe His Ser Ile Asn Tyr Tyr Phe Ile Asn Ser Gln 
305                 310                 315                 320 


Gly His Pro Ile Glu Gly Leu Ala Val Met Tyr Tyr Ile Ala His Leu 
                325                 330                 335     


Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly Ser Gly 
            340                 345                 350         


Trp Ala Phe Ile Lys Tyr Val Leu Ser Asp Lys Glu Lys Lys Val Phe 
        355                 360                 365             


Gly Ile Val Ile Pro Met Gln Val Leu Ala Asn Val Ala Tyr Ile Ile 
    370                 375                 380                 


Ile Glu Ser Arg Glu Glu Gly Ala Ser Asp Tyr Val Leu Trp Lys Glu 
385                 390                 395                 400 


Ile Leu Phe Leu Val Asp Leu Ile Cys Cys Gly Ala Ile Leu Phe Pro 
                405                 410                 415     


Val Val Trp Ser Ile Arg His Leu Gln Asp Ala Ser Gly Thr Asp Gly 
            420                 425                 430         


Lys Val Ala Val Asn Leu Ala Lys Leu Lys Leu Phe Arg His Tyr Tyr 
        435                 440                 445             


Val Met Val Ile Cys Tyr Val Tyr Phe Thr Arg Ile Ile Ala Ile Leu 
    450                 455                 460                 


Leu Gln Val Ala Val Pro Phe Gln Trp Gln Trp Leu Tyr Gln Leu Leu 
465                 470                 475                 480 


Val Glu Gly Ser Thr Leu Ala Phe Phe Val Leu Thr Gly Tyr Lys Phe 
                485                 490                 495     


Gln Pro Thr Gly Asn Asn Pro Tyr Leu Gln Leu Pro Gln Glu Asp Glu 
            500                 505                 510         


Glu Asp Val Gln Met Glu Gln Val Met Thr Asp Ser Gly Phe Arg Glu 
        515                 520                 525             


Gly Leu Ser Lys Val Asn Lys Thr Ala Ser Gly Arg Glu Leu Leu 
    530                 535                 540             


<210>  3668
<211>  2215
<212>  DNA
<213>  Homosapiens

<400>  3668
gatccccttc ggtcctccgg atggagttgc cgggtccgcc tcgctggggt cggccccctc     60

ccttcggggg cgaggctcca tctcttgggg actacacccc ccttcccccc aactgggtct    120

tagtccttta aattcttgga atcacttttg gggcgctaga gaccctggag ccgcacagcg    180

gggtcctggg gggctataga gtggggtcct ctgggcactt aatgggattt ggggggttct    240

gttgaaatat tgctgggagc tcaactggaa tgtaaaagtt cttcgggaag gtgaaggtca    300

ggcacgccga gggggagaag cgagcggaca tccagctgaa cagcttcggt ttctacacca    360

atggctctct ggaggtggag ttgagcgtcc tgcggctggg cctccgggag gcagaagaga    420

agtccctgct ggtggggttc agtctcagcc gggttcggtc tggcagagtt cgctcctatt    480

caacccggga tttccaggac tgccctctcc agaaaaacag tagcagtttc ctggtcctgt    540

tcctcatcaa caccaaggat ctgcaggtcc aggtgcggaa gtatggagag cagaagacgt    600

tgtttatctt tcccgggctc ctcccggaag caccctccaa accagggctc ccgaagccac    660

aggccacagt cccccgcaag gtggatggcg gagggacctc tgcagccagc aagcccaagt    720

caacacccgc agtgattcag ggtcctagtg ggaaggacaa ggacctggtg ttgggcctga    780

gccacctcaa caactcctac aacttcagtt tccacgtggt gatcggctct caggcggaag    840

aaggccagta cagcctgaac ttccacaact gcaacaattc agtgccagga aaggagcatc    900

cattcgacat cacggtgatg atccgggaga agaaccccga tggcttcctg tcggcagcgg    960

agatgcccct tttcaagctc tacatggtca tgtccgcctg cttcctggcc gctggcatct   1020

tctgggtgtc catcctctgc aggaacacgt acagcgtctt caagatccac tggctcatgg   1080

cggccttggc cttcaccaag agcatctctc tcctcttcca cagcatcaac tactacttca   1140

tcaacagcca gggccacccc atcgaaggcc ttgccgtcat gtactacatc gcacacctgc   1200

tgaagggcgc cctcctcttc atcaccatcg ccctgattgg ctcaggctgg gccttcatca   1260

agtacgtcct gtcggataag gagaagaagg tctttgggat cgtgatcccc atgcaggtcc   1320

tggccaacgt ggcctacatc atcatcgagt cccgcgagga aggcgccagc gactacgtgc   1380

tgtggaagga gattttgttc ctggtggacc tcatctgctg tggtgccatc ctgttccccg   1440

tagtctggtc catccggcat ctccaggatg cgtctggcac agacgggaag gtggcagtga   1500

acctggccaa gctgaagctg ttccggcatt actatgtcat ggtcatctgc tacgtctact   1560

tcacccgcat catcgccatc ctgctgcagg tggctgtgcc ctttcagtgg cagtggctgt   1620

accagctctt ggtggagggc tccaccctgg ccttcttcgt gctcacgggc tacaagttcc   1680

agcccacagg aaacaacccg tacctgcagc tgccccagga ggacgaggag gatgttcaga   1740

tggagcaagt aatgacggac tctgggttcc gggaaggcct ctccaaagtc aacaaaacag   1800

ccagcgggcg ggaactgtta tgatcacctc cacatctcag accaaagggt cgtcctcccc   1860

cagcatttct cactcctgcc cttcttccac agcgtatgtg gggaggtgga gggggtccat   1920

gtggaccagg cgcccagctc cccgggaccc cggttcccgg acaagcccat ttggaagaag   1980

agtcccttcc tccccccaaa tattgggcag ccctgtcctt accccgggac cacccctccc   2040

ttccagctat gtgtacaata atgaccaatc tgtttggcta cgccgttgtc ttgccttttt   2100

gggggttggg gtctacacgg aggttgtgtt tacaatgtag aaacctgttt tcgctgtgtg   2160

tggcgggggc gcgggcacag ggtccgtgtc tttgtatatt caataaatat tcatt        2215


<210>  3669
<211>  301
<212>  PRT
<213>  Homosapiens

<400>  3669

Met Ile Arg Glu Lys Asn Pro Asp Gly Phe Leu Ser Ala Ala Glu Met 
1               5                   10                  15      


Pro Leu Phe Lys Leu Tyr Met Val Met Ser Ala Cys Phe Leu Ala Ala 
            20                  25                  30          


Gly Ile Phe Trp Val Ser Ile Leu Cys Arg Asn Thr Tyr Ser Val Phe 
        35                  40                  45              


Lys Ile His Trp Leu Met Ala Ala Leu Ala Phe Thr Lys Ser Ile Ser 
    50                  55                  60                  


Leu Leu Phe His Ser Ile Asn Tyr Tyr Phe Ile Asn Ser Gln Gly His 
65                  70                  75                  80  


Pro Ile Glu Gly Leu Ala Val Met Tyr Tyr Ile Ala His Leu Leu Lys 
                85                  90                  95      


Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly Ser Gly Trp Ala 
            100                 105                 110         


Phe Ile Lys Tyr Val Leu Ser Asp Lys Glu Lys Lys Val Phe Gly Ile 
        115                 120                 125             


Val Ile Pro Met Gln Val Leu Ala Asn Val Ala Tyr Ile Ile Ile Glu 
    130                 135                 140                 


Ser Arg Glu Glu Gly Ala Ser Asp Tyr Val Leu Trp Lys Glu Ile Leu 
145                 150                 155                 160 


Phe Leu Val Asp Leu Ile Cys Cys Gly Ala Ile Leu Phe Pro Val Val 
                165                 170                 175     


Trp Ser Ile Arg His Leu Gln Asp Ala Ser Gly Thr Asp Gly Lys Val 
            180                 185                 190         


Ala Val Asn Leu Ala Lys Leu Lys Leu Phe Arg His Tyr Tyr Val Met 
        195                 200                 205             


Val Ile Cys Tyr Val Tyr Phe Thr Arg Ile Ile Ala Ile Leu Leu Gln 
    210                 215                 220                 


Val Ala Val Pro Phe Gln Trp Gln Trp Leu Tyr Gln Leu Leu Val Glu 
225                 230                 235                 240 


Gly Ser Thr Leu Ala Phe Phe Val Leu Thr Gly Tyr Lys Phe Gln Pro 
                245                 250                 255     


Thr Gly Asn Asn Pro Tyr Leu Gln Leu Pro Gln Glu Asp Glu Glu Asp 
            260                 265                 270         


Val Gln Met Glu Gln Val Met Thr Asp Ser Gly Phe Arg Glu Gly Leu 
        275                 280                 285             


Ser Lys Val Asn Lys Thr Ala Ser Gly Arg Glu Leu Leu 
    290                 295                 300     


<210>  3670
<211>  1812
<212>  DNA
<213>  Homosapiens

<400>  3670
tggctctctg gaggtggagt tgagcgtcct gcggctgggc ctccgggagg cagaagagaa     60

gtccctgctg gtggggttca gtctcagccg ggttcggtct ggcagagttc gctcctattc    120

aacccgggat ttccaggact gccctctcca gaaaaacagt agcagtttcc tggtcctgtt    180

cctcatcaac accaaggatc tgcagtgagt tggggaccgg gggctcgctc agatccttcg    240

tctgcgtttc cctggtgtga tgcccacacg cacctgggct gatcagggtc caggtgcgga    300

agtatggaga gcagaagacg ttgtttatct ttcccgggct cctcccggaa gcaccctcca    360

aaccagggct cccgaagcca caggccacag tcccccgcaa ggtggatggc ggagggacct    420

ctgcagccag caagcccaag tcaacacccg cagtgattca gggtcctagt gggaaggaca    480

aggacctggt gttgggcctg agccacctca acaactccta caacttcagt ttccacgtgg    540

tgatcggctc tcaggcggaa gaaggccagt acagcctgaa cttccacaac tgcaacaatt    600

cagtgccagg aaaggagcat ccattcgaca tcacggtgat gatccgggag aagaaccccg    660

atggcttcct gtcggcagcg gagatgcccc ttttcaagct ctacatggtc atgtccgcct    720

gcttcctggc cgctggcatc ttctgggtgt ccatcctctg caggaacaca tcaactacta    780

cttcatcaac agccagggcc accccatcga aggccttgcc gtcatgtact acatcgcaca    840

cctgctgaag ggcgccctcc tcttcatcac catcgccctg attggctcag gctgggcctt    900

catcaagtac gtcctgtcgg ataaggagaa gaaggtcttt gggatcgtga tccccatgca    960

ggtcctggcc aacgtggcct acatcatcat cgagtcccgc gaggaaggcg ccagcgacta   1020

cgtgctgtgg aaggagattt tgttcctggt ggacctcatc tgctgtggtg ccatcctgtt   1080

ccccgtagtc tggtccatcc ggcatctcca ggatgcgtct ggcacagacg ggaaggtggc   1140

agtgaacctg gccaagctga agctgttccg gcattactat gtcatggtgg ctgtgccctt   1200

tcagtggcag tggctgtacc agctcttggt ggagggctcc accctggcct tcttcgtgct   1260

cacgggctac aagttccagc ccacaggaaa caacccgtac ctgcagctgc cccaggagga   1320

cgaggaggat gttcagatgg agcaagtaat gacggactct gggttccggg aaggcctctc   1380

caaagtcaac aaaacagcca gcgggcggga actgttatga tcacctccac atctcagacc   1440

aaagggtcgt cctcccccag catttctcac tcctgccctt cttccacagc gtatgtgggg   1500

aggtggaggg ggtccatgtg gaccaggcgc ccagctcccc gggaccccgg ttcccggaca   1560

agcccatttg gaagaagagt cccttcctcc ccccaaatat tgggcagccc tgtccttacc   1620

ccgggaccac ccctcccttc cagctatgtg tacaataatg accaatctgt ttggctacgc   1680

cgttgtcttg cctttttggg ggttggggtc tacacggagg ttgtgtttac aatgtagaaa   1740

cctgttttcg ctgtgtgtgg cgggggcgcg ggcacagggt ccgtgtcttt gtatattcaa   1800

taaatattca tt                                                       1812


<210>  3671
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  3671

Met Tyr Tyr Ile Ala His Leu Leu Lys Gly Ala Leu Leu Phe Ile Thr 
1               5                   10                  15      


Ile Ala Leu Ile Gly Ser Gly Trp Ala Phe Ile Lys Tyr Val Leu Ser 
            20                  25                  30          


Asp Lys Glu Lys Lys Val Phe Gly Ile Val Ile Pro Met Gln Val Leu 
        35                  40                  45              


Ala Asn Val Ala Tyr Ile Ile Ile Glu Ser Arg Glu Glu Gly Ala Ser 
    50                  55                  60                  


Asp Tyr Val Leu Trp Lys Glu Ile Leu Phe Leu Val Asp Leu Ile Cys 
65                  70                  75                  80  


Cys Gly Ala Ile Leu Phe Pro Val Val Trp Ser Ile Arg His Leu Gln 
                85                  90                  95      


Asp Ala Ser Gly Thr Asp Gly Lys Val Ala Val Asn Leu Ala Lys Leu 
            100                 105                 110         


Lys Leu Phe Arg His Tyr Tyr Val Met Val Ala Val Pro Phe Gln Trp 
        115                 120                 125             


Gln Trp Leu Tyr Gln Leu Leu Val Glu Gly Ser Thr Leu Ala Phe Phe 
    130                 135                 140                 


Val Leu Thr Gly Tyr Lys Phe Gln Pro Thr Gly Asn Asn Pro Tyr Leu 
145                 150                 155                 160 


Gln Leu Pro Gln Glu Asp Glu Glu Asp Val Gln Met Glu Gln Val Met 
                165                 170                 175     


Thr Asp Ser Gly Phe Arg Glu Gly Leu Ser Lys Val Asn Lys Thr Ala 
            180                 185                 190         


Ser Gly Arg Glu Leu Leu 
        195             


<210>  3672
<211>  748
<212>  DNA
<213>  Homosapiens

<400>  3672
tgccatcctg ttccccgtag tctgtggcag tgaacctggc caagctgaag ctgttccggc     60

attactatgt catggtcatc tgctacgtct acttcacccg catcatcgcc atcctgctgc    120

aggtggctgt gccctttcag tggcagtggc tgtaccagct cttggtggag ggctccaccc    180

tggccttctt cgtgctcacg ggctacaagt tccagcccac aggaaacaac ccgtacctgc    240

agctgcccca ggaggacgag gaggatgttc agatggagca agtaatgacg gactctgggt    300

tccgggaagg cctctccaaa gtcaacaaaa cagccagcgg gcgggaactg ttatgatcac    360

ctccacatct cagaccaaag ggtcgtcctc ccccagcatt tctcactcct gcccttcttc    420

cacagcgtat gtggggaggt ggagggggtc catgtggacc aggcgcccag ctccccggga    480

ccccggttcc cggacaagcc catttggaag aagagtccct tcctcccccc aaatattggg    540

cagccctgtc cttaccccgg gaccacccct cccttccagc tatgtgtaca ataatgacca    600

atctgtttgg ctacgccgtt gtcttgcctt tttgggggtt ggggtctaca cggaggttgt    660

gtttacaatg tagaaacctg ttttcgctgt gtgtggcggg ggcgcgggca cagggtccgt    720

gtctttgtat attcaataaa tattcatt                                       748


<210>  3673
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  3673

Met Val Ile Cys Tyr Val Tyr Phe Thr Arg Ile Ile Ala Ile Leu Leu 
1               5                   10                  15      


Gln Val Ala Val Pro Phe Gln Trp Gln Trp Leu Tyr Gln Leu Leu Val 
            20                  25                  30          


Glu Gly Ser Thr Leu Ala Phe Phe Val Leu Thr Gly Tyr Lys Phe Gln 
        35                  40                  45              


Pro Thr Gly Asn Asn Pro Tyr Leu Gln Leu Pro Gln Glu Asp Glu Glu 
    50                  55                  60                  


Asp Val Gln Met Glu Gln Val Met Thr Asp Ser Gly Phe Arg Glu Gly 
65                  70                  75                  80  


Leu Ser Lys Val Asn Lys Thr Ala Ser Gly Arg Glu Leu Leu 
                85                  90                  


<210>  3674
<211>  1309
<212>  DNA
<213>  Homosapiens

<400>  3674
cgtctctgat tgtccaacta ttcacccctt cagctgtgac tgttccctcc attttttcag     60

ccccgattac cagttttgag tcccacccac cgtcctcatt attcaacttt ctgaccaccc    120

atctgatggt gacggtccgt gttcctaatc ccccaccacc accatcagcc tcccacccct    180

ctgtgcgcct cactgtccgt ctgtccatcc acccccagat caactactac ttcatcaaca    240

gccagggcca ccccatcgaa ggccttgccg tcatgtacta catcgcacac ctgctgaagg    300

gcgccctcct cttcatcacc atcgccctga ttggctcagg ctgggccttc atcaagtacg    360

tcctgtcgga taaggagaag aaggtctttg ggatcgtgat ccccatgcag gtcctggcca    420

acgtggccta catcatcatc gagtcccgcg aggaaggcgc cagcgactac gtgctgtgga    480

aggagatttt gttcctggtg gacctcatct gctgtggtgc catcctgttc cccgtagtct    540

ggtccatccg gcatctccag gatgcgtctg gcacagacgg gaaggtggca gtgaacctgg    600

ccaagctgaa gctgttccgg cattactatg tcatggtcat ctgctacgtc tacttcaccc    660

gcatcatcgc catcctgctg caggtggctg tgccctttca gtggcagtgg ctgtaccagc    720

tcttggtgga gggctccacc ctggccttct tcgtgctcac gggctacaag ttccagccca    780

caggaaacaa cccgtacctg cagctgcccc aggaggacga ggaggatgtt cagatggagc    840

aagtaatgac ggactctggg ttccgggaag gcctctccaa agtcaacaaa acagccagcg    900

ggcgggaact gttatgatca cctccacatc tcagaccaaa gggtcgtcct cccccagcat    960

ttctcactcc tgcccttctt ccacagcgta tgtggggagg tggagggggt ccatgtggac   1020

caggcgccca gctccccggg accccggttc ccggacaagc ccatttggaa gaagagtccc   1080

ttcctccccc caaatattgg gcagccctgt ccttaccccg ggaccacccc tcccttccag   1140

ctatgtgtac aataatgacc aatctgtttg gctacgccgt tgtcttgcct ttttgggggt   1200

tggggtctac acggaggttg tgtttacaat gtagaaacct gttttcgctg tgtgtggcgg   1260

gggcgcgggc acagggtccg tgtctttgta tattcaataa atattcatt               1309


<210>  3675
<211>  263
<212>  PRT
<213>  Homosapiens

<400>  3675

Met Val Thr Val Arg Val Pro Asn Pro Pro Pro Pro Pro Ser Ala Ser 
1               5                   10                  15      


His Pro Ser Val Arg Leu Thr Val Arg Leu Ser Ile His Pro Gln Ile 
            20                  25                  30          


Asn Tyr Tyr Phe Ile Asn Ser Gln Gly His Pro Ile Glu Gly Leu Ala 
        35                  40                  45              


Val Met Tyr Tyr Ile Ala His Leu Leu Lys Gly Ala Leu Leu Phe Ile 
    50                  55                  60                  


Thr Ile Ala Leu Ile Gly Ser Gly Trp Ala Phe Ile Lys Tyr Val Leu 
65                  70                  75                  80  


Ser Asp Lys Glu Lys Lys Val Phe Gly Ile Val Ile Pro Met Gln Val 
                85                  90                  95      


Leu Ala Asn Val Ala Tyr Ile Ile Ile Glu Ser Arg Glu Glu Gly Ala 
            100                 105                 110         


Ser Asp Tyr Val Leu Trp Lys Glu Ile Leu Phe Leu Val Asp Leu Ile 
        115                 120                 125             


Cys Cys Gly Ala Ile Leu Phe Pro Val Val Trp Ser Ile Arg His Leu 
    130                 135                 140                 


Gln Asp Ala Ser Gly Thr Asp Gly Lys Val Ala Val Asn Leu Ala Lys 
145                 150                 155                 160 


Leu Lys Leu Phe Arg His Tyr Tyr Val Met Val Ile Cys Tyr Val Tyr 
                165                 170                 175     


Phe Thr Arg Ile Ile Ala Ile Leu Leu Gln Val Ala Val Pro Phe Gln 
            180                 185                 190         


Trp Gln Trp Leu Tyr Gln Leu Leu Val Glu Gly Ser Thr Leu Ala Phe 
        195                 200                 205             


Phe Val Leu Thr Gly Tyr Lys Phe Gln Pro Thr Gly Asn Asn Pro Tyr 
    210                 215                 220                 


Leu Gln Leu Pro Gln Glu Asp Glu Glu Asp Val Gln Met Glu Gln Val 
225                 230                 235                 240 


Met Thr Asp Ser Gly Phe Arg Glu Gly Leu Ser Lys Val Asn Lys Thr 
                245                 250                 255     


Ala Ser Gly Arg Glu Leu Leu 
            260             


<210>  3676
<211>  1158
<212>  DNA
<213>  Homosapiens

<400>  3676
tattgctggg agctcaactg gaatgtaaaa gttcttcggg aagagcatct ctctcctctt     60

ccacagcatc aactactact tcatcaacag ccagggccac cccatcgaag gccttgccgt    120

catgtactac atcgcacacc tgctgaaggg cgccctcctc ttcatcacca tcgccctgat    180

tggctcaggc tgggccttca tcaagtacgt cctgtcggat aaggagaaga aggtctttgg    240

gatcgtgatc cccatgcagg tcctggccaa cgtggcctac atcatcatcg agtcccgcga    300

ggaaggcgcc agcgactacg tgctgtggaa ggagattttg ttcctggtgg acctcatctg    360

ctgtggtgcc atcctgttcc ccgtagtctg gtccatccgg catctccagg atgcgtctgg    420

cacagacggg aaggtggcag tgaacctggc caagctgaag ctgttccggc attactatgt    480

catggtcatc tgctacgtct acttcacccg catcatcgcc atcctgctgc aggtggctgt    540

gccctttcag tggcagtggc tgtaccagct cttggtggag ggctccaccc tggccttctt    600

cgtgctcacg ggctacaagt tccagcccac aggaaacaac ccgtacctgc agctgcccca    660

ggaggacgag gaggatgttc agatggagca agtaatgacg gactctgggt tccgggaagg    720

cctctccaaa gtcaacaaaa cagccagcgg gcgggaactg ttatgatcac ctccacatct    780

cagaccaaag ggtcgtcctc ccccagcatt tctcactcct gcccttcttc cacagcgtat    840

gtggggaggt ggagggggtc catgtggacc aggcgcccag ctccccggga ccccggttcc    900

cggacaagcc catttggaag aagagtccct tcctcccccc aaatattggg cagccctgtc    960

cttaccccgg gaccacccct cccttccagc tatgtgtaca ataatgacca atctgtttgg   1020

ctacgccgtt gtcttgcctt tttgggggtt ggggtctaca cggaggttgt gtttacaatg   1080

tagaaacctg ttttcgctgt gtgtggcggg ggcgcgggca cagggtccgt gtctttgtat   1140

attcaataaa tattcatt                                                 1158


<210>  3677
<211>  214
<212>  PRT
<213>  Homosapiens

<400>  3677

Met Tyr Tyr Ile Ala His Leu Leu Lys Gly Ala Leu Leu Phe Ile Thr 
1               5                   10                  15      


Ile Ala Leu Ile Gly Ser Gly Trp Ala Phe Ile Lys Tyr Val Leu Ser 
            20                  25                  30          


Asp Lys Glu Lys Lys Val Phe Gly Ile Val Ile Pro Met Gln Val Leu 
        35                  40                  45              


Ala Asn Val Ala Tyr Ile Ile Ile Glu Ser Arg Glu Glu Gly Ala Ser 
    50                  55                  60                  


Asp Tyr Val Leu Trp Lys Glu Ile Leu Phe Leu Val Asp Leu Ile Cys 
65                  70                  75                  80  


Cys Gly Ala Ile Leu Phe Pro Val Val Trp Ser Ile Arg His Leu Gln 
                85                  90                  95      


Asp Ala Ser Gly Thr Asp Gly Lys Val Ala Val Asn Leu Ala Lys Leu 
            100                 105                 110         


Lys Leu Phe Arg His Tyr Tyr Val Met Val Ile Cys Tyr Val Tyr Phe 
        115                 120                 125             


Thr Arg Ile Ile Ala Ile Leu Leu Gln Val Ala Val Pro Phe Gln Trp 
    130                 135                 140                 


Gln Trp Leu Tyr Gln Leu Leu Val Glu Gly Ser Thr Leu Ala Phe Phe 
145                 150                 155                 160 


Val Leu Thr Gly Tyr Lys Phe Gln Pro Thr Gly Asn Asn Pro Tyr Leu 
                165                 170                 175     


Gln Leu Pro Gln Glu Asp Glu Glu Asp Val Gln Met Glu Gln Val Met 
            180                 185                 190         


Thr Asp Ser Gly Phe Arg Glu Gly Leu Ser Lys Val Asn Lys Thr Ala 
        195                 200                 205             


Ser Gly Arg Glu Leu Leu 
    210                 


<210>  3678
<211>  1922
<212>  DNA
<213>  Homosapiens

<400>  3678
gggcgccaga ggcggagtcg gggaggaggt ggctccagag atggcagtga gcgagaggag     60

ggggctcggc cgcgggagcc ccgcggagtg ggggcagcgg ctacttctgg tgctgctgct    120

gggtggctgc tccgggcgca tccaccagct ggcgctgacg ggggagaagc gagcggacat    180

ccagctgaac agcttcggtt tctacaccaa tggctctctg gaggtggagt tgagcgtcct    240

gcggctgggc ctccgggagg cagaagagaa gtccctgctg gtggggttca gtctcagccg    300

ggttcggtct ggcagagttc gctcctattc aacccgggat ttccaggact gccctctcca    360

gaaaaacagt agcagtttcc tggtcctgtt cctcatcaac accaaggatc tgcaggtcca    420

ggtgcggaag tatggagagc agaagacgtt gtttatcttt cccgggctcc tcccggaagc    480

accctccaaa ccagggctcc cgaagccaca ggccacagtc ccccgcaagg tggatggcgg    540

agggacctct gcagccagca agcccaagtc aacacccgca gtgattcagg gtcctagtgg    600

gaaggacaag gacctggtgt tgggcctgag ccacctcaac aactcctaca acttcagttt    660

ccacgtggtg atcggctctc aggcggaaga aggccagtac agcctgaact tccacaactg    720

caacaattca gtgccaggaa aggagcatcc attcgacatc acggtgatga tccgggagaa    780

gaaccccgat ggcttcctgt cggcagcgga gatgcccctt ttcaagctct acatggtcat    840

gtccgcctgc ttcctggccg ctggcatctt ctgggtgtcc atcctctgca ggaacacgta    900

cagcgtcttc aagatccact ggctcatggc ggccttggcc ttcaccaaga gcatctctct    960

cctcttccac agcatcaact actacttcat caacagccag ggccacccca tcgaaggcct   1020

tgccgtcatg tactacatcg cacacctgct gaagggcgcc ctcctcttca tcaccatcgc   1080

cctgattggc tcaggctggg ccttcatcaa gtacgtcctg tcggataagg agaagaaggt   1140

ctttgggatc gtgatcccca tgcaggtcct ggccaacgtg gcctacatca tcatcgagtc   1200

ccgcgaggaa ggcgccagcg actacgtgct gtggaaggag attttgttcc tggtggacct   1260

catctgctgt ggtgccatcc tgttccccgt agtctggtcc atccggcatc tccaggatgc   1320

gtctggcaca gacgggaagg tggcagtgaa cctggccaag ctgaagctgt tccggcatta   1380

ctatgtcatg gtcatctgct acgtctactt cacccgcatc atcgccatcc tgctgcaggt   1440

ggctgtgccc tttcagtggc agtggctgta ccagctcttg gtggagggct ccaccctggc   1500

cttcttcgtg ctcacgggct acaagttcca gcccacagga aacaacccgt acctgcagct   1560

gccccaggag gacgaggagg atgttcagat ggagcaagtc gtatgtgggg aggtggaggg   1620

ggtccatgtg gaccaggcgc ccagctcccc gggaccccgg ttcccggaca agcccatttg   1680

gaagaagagt cccttcctcc ccccaaatat tgggcagccc tgtccttacc ccgggaccac   1740

ccctcccttc cagctatgtg tacaataatg accaatctgt ttggctacgc cgttgtcttg   1800

cctttttggg ggttggggtc tacacggagg ttgtgtttac aatgtagaaa cctgttttcg   1860

ctgtgtgtgg cgggggcgcg ggcacagggt ccgtgtcttt gtatattcaa taaatattca   1920

tt                                                                  1922


<210>  3679
<211>  575
<212>  PRT
<213>  Homosapiens

<400>  3679

Met Ala Val Ser Glu Arg Arg Gly Leu Gly Arg Gly Ser Pro Ala Glu 
1               5                   10                  15      


Trp Gly Gln Arg Leu Leu Leu Val Leu Leu Leu Gly Gly Cys Ser Gly 
            20                  25                  30          


Arg Ile His Gln Leu Ala Leu Thr Gly Glu Lys Arg Ala Asp Ile Gln 
        35                  40                  45              


Leu Asn Ser Phe Gly Phe Tyr Thr Asn Gly Ser Leu Glu Val Glu Leu 
    50                  55                  60                  


Ser Val Leu Arg Leu Gly Leu Arg Glu Ala Glu Glu Lys Ser Leu Leu 
65                  70                  75                  80  


Val Gly Phe Ser Leu Ser Arg Val Arg Ser Gly Arg Val Arg Ser Tyr 
                85                  90                  95      


Ser Thr Arg Asp Phe Gln Asp Cys Pro Leu Gln Lys Asn Ser Ser Ser 
            100                 105                 110         


Phe Leu Val Leu Phe Leu Ile Asn Thr Lys Asp Leu Gln Val Gln Val 
        115                 120                 125             


Arg Lys Tyr Gly Glu Gln Lys Thr Leu Phe Ile Phe Pro Gly Leu Leu 
    130                 135                 140                 


Pro Glu Ala Pro Ser Lys Pro Gly Leu Pro Lys Pro Gln Ala Thr Val 
145                 150                 155                 160 


Pro Arg Lys Val Asp Gly Gly Gly Thr Ser Ala Ala Ser Lys Pro Lys 
                165                 170                 175     


Ser Thr Pro Ala Val Ile Gln Gly Pro Ser Gly Lys Asp Lys Asp Leu 
            180                 185                 190         


Val Leu Gly Leu Ser His Leu Asn Asn Ser Tyr Asn Phe Ser Phe His 
        195                 200                 205             


Val Val Ile Gly Ser Gln Ala Glu Glu Gly Gln Tyr Ser Leu Asn Phe 
    210                 215                 220                 


His Asn Cys Asn Asn Ser Val Pro Gly Lys Glu His Pro Phe Asp Ile 
225                 230                 235                 240 


Thr Val Met Ile Arg Glu Lys Asn Pro Asp Gly Phe Leu Ser Ala Ala 
                245                 250                 255     


Glu Met Pro Leu Phe Lys Leu Tyr Met Val Met Ser Ala Cys Phe Leu 
            260                 265                 270         


Ala Ala Gly Ile Phe Trp Val Ser Ile Leu Cys Arg Asn Thr Tyr Ser 
        275                 280                 285             


Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Ala Phe Thr Lys Ser 
    290                 295                 300                 


Ile Ser Leu Leu Phe His Ser Ile Asn Tyr Tyr Phe Ile Asn Ser Gln 
305                 310                 315                 320 


Gly His Pro Ile Glu Gly Leu Ala Val Met Tyr Tyr Ile Ala His Leu 
                325                 330                 335     


Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly Ser Gly 
            340                 345                 350         


Trp Ala Phe Ile Lys Tyr Val Leu Ser Asp Lys Glu Lys Lys Val Phe 
        355                 360                 365             


Gly Ile Val Ile Pro Met Gln Val Leu Ala Asn Val Ala Tyr Ile Ile 
    370                 375                 380                 


Ile Glu Ser Arg Glu Glu Gly Ala Ser Asp Tyr Val Leu Trp Lys Glu 
385                 390                 395                 400 


Ile Leu Phe Leu Val Asp Leu Ile Cys Cys Gly Ala Ile Leu Phe Pro 
                405                 410                 415     


Val Val Trp Ser Ile Arg His Leu Gln Asp Ala Ser Gly Thr Asp Gly 
            420                 425                 430         


Lys Val Ala Val Asn Leu Ala Lys Leu Lys Leu Phe Arg His Tyr Tyr 
        435                 440                 445             


Val Met Val Ile Cys Tyr Val Tyr Phe Thr Arg Ile Ile Ala Ile Leu 
    450                 455                 460                 


Leu Gln Val Ala Val Pro Phe Gln Trp Gln Trp Leu Tyr Gln Leu Leu 
465                 470                 475                 480 


Val Glu Gly Ser Thr Leu Ala Phe Phe Val Leu Thr Gly Tyr Lys Phe 
                485                 490                 495     


Gln Pro Thr Gly Asn Asn Pro Tyr Leu Gln Leu Pro Gln Glu Asp Glu 
            500                 505                 510         


Glu Asp Val Gln Met Glu Gln Val Val Cys Gly Glu Val Glu Gly Val 
        515                 520                 525             


His Val Asp Gln Ala Pro Ser Ser Pro Gly Pro Arg Phe Pro Asp Lys 
    530                 535                 540                 


Pro Ile Trp Lys Lys Ser Pro Phe Leu Pro Pro Asn Ile Gly Gln Pro 
545                 550                 555                 560 


Cys Pro Tyr Pro Gly Thr Thr Pro Pro Phe Gln Leu Cys Val Gln 
                565                 570                 575 


<210>  3680
<211>  1907
<212>  DNA
<213>  Homosapiens

<400>  3680
tgcggctggg cctccgggag gcagaagaga agtccctgct ggtggggttc agtctcagcc     60

gggttcggtc tggcagagtt cgctcctatt caacccggga tttccaggac tgccctctcc    120

agaaaaacag tagcagtttc ctggtcctgt tcctcatcaa caccaaggat ctgcagtgag    180

ttggggaccg ggggctcgct cagatccttc gtctgcgttt ccctggtgtg atgcccacac    240

gcacctgggc tgatcagggt ccaggtgcgg aagtatggag agcagaagac gttgtttatc    300

tttcccgggc tcctcccgga agcaccctcc aaaccagggc tcccgaagcc acaggccaca    360

gtcccccgca aggtggatgg cggagggacc tctgcagcca gcaagcccaa gtcaacaccc    420

gcagtgattc agggtcctag tgggaaggac aaggacctgg tgttgggcct gagccacctc    480

aacaactcct acaacttcag tttccacgtg gtgatcggct ctcaggcgga agaaggccag    540

tacagcctga acttccacaa ctgcaacaat tcagtgccag gaaaggagca tccattcgac    600

atcacggtga tgatccggga gaagaacccc gatggcttcc tgtcggcagc ggagatgccc    660

cttttcaagc tctacatggt catgtccgcc tgcttcctgg ccgctggcat cttctgggtg    720

tccatcctct gcaggaacac gtacagcgtc ttcaagatcc actggctcat ggcggccttg    780

gccttcacca agagcatctc tctcctcttc cacagcatca actactactt catcaacagc    840

cagggccacc ccatcgaagg ccttgccgtc atgtactaca tcgcacacct gctgaagggc    900

gccctcctct tcatcaccat cgccctgatt ggctcaggct gggccttcat caagtacgtc    960

ctgtcggata aggagaagaa ggtctttggg atcgtgatcc ccatgcaggt cctggccaac   1020

gtggcctaca tcatcatcga gtcccgcgag gaaggcgcca gcgactacgt gctgtggaag   1080

gagattttgt tcctggtgga cctcatctgc tgtggtgcca tcctgttccc cgtagtctgg   1140

tccatccggc atctccagga tgcgtctggc acagacggga aggtggcagt gaacctggcc   1200

aagctgaagc tgttccggca ttactatgtc atggtcatct gctacgtcta cttcacccgc   1260

atcatcgcca tcctgctgca ggtggctgtg ccctttcagt ggcagtggct gtaccagctc   1320

ttggtggagg gctccaccct ggccttcttc gtgctcacgg gctacaagtt ccagcccaca   1380

ggaaacaacc cgtacctgca gctgccccag gaggacgagg aggatgttca gatggagcaa   1440

gtaatgacgg actctgggtt ccgggaaggc ctctccaaag tcaacaaaac agccagcggg   1500

cgggaactgt tatgatcacc tccacatctc agaccaaagg gtcgtcctcc cccagcattt   1560

ctcactcctg cccttcttcc acagcgtatg tggggaggtg gagggggtcc atgtggacca   1620

ggcgcccagc tccccgggac cccggttccc ggacaagccc atttggaaga agagtccctt   1680

cctcccccca aatattgggc agccctgtcc ttaccccggg accacccctc ccttccagct   1740

atgtgtacaa taatgaccaa tctgtttggc tacgccgttg tcttgccttt ttgggggttg   1800

gggtctacac ggaggttgtg tttacaatgt agaaacctgt tttcgctgtg tgtggcgggg   1860

gcgcgggcac agggtccgtg tctttgtata ttcaataaat attcatt                 1907


<210>  3681
<211>  301
<212>  PRT
<213>  Homosapiens

<400>  3681

Met Ile Arg Glu Lys Asn Pro Asp Gly Phe Leu Ser Ala Ala Glu Met 
1               5                   10                  15      


Pro Leu Phe Lys Leu Tyr Met Val Met Ser Ala Cys Phe Leu Ala Ala 
            20                  25                  30          


Gly Ile Phe Trp Val Ser Ile Leu Cys Arg Asn Thr Tyr Ser Val Phe 
        35                  40                  45              


Lys Ile His Trp Leu Met Ala Ala Leu Ala Phe Thr Lys Ser Ile Ser 
    50                  55                  60                  


Leu Leu Phe His Ser Ile Asn Tyr Tyr Phe Ile Asn Ser Gln Gly His 
65                  70                  75                  80  


Pro Ile Glu Gly Leu Ala Val Met Tyr Tyr Ile Ala His Leu Leu Lys 
                85                  90                  95      


Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly Ser Gly Trp Ala 
            100                 105                 110         


Phe Ile Lys Tyr Val Leu Ser Asp Lys Glu Lys Lys Val Phe Gly Ile 
        115                 120                 125             


Val Ile Pro Met Gln Val Leu Ala Asn Val Ala Tyr Ile Ile Ile Glu 
    130                 135                 140                 


Ser Arg Glu Glu Gly Ala Ser Asp Tyr Val Leu Trp Lys Glu Ile Leu 
145                 150                 155                 160 


Phe Leu Val Asp Leu Ile Cys Cys Gly Ala Ile Leu Phe Pro Val Val 
                165                 170                 175     


Trp Ser Ile Arg His Leu Gln Asp Ala Ser Gly Thr Asp Gly Lys Val 
            180                 185                 190         


Ala Val Asn Leu Ala Lys Leu Lys Leu Phe Arg His Tyr Tyr Val Met 
        195                 200                 205             


Val Ile Cys Tyr Val Tyr Phe Thr Arg Ile Ile Ala Ile Leu Leu Gln 
    210                 215                 220                 


Val Ala Val Pro Phe Gln Trp Gln Trp Leu Tyr Gln Leu Leu Val Glu 
225                 230                 235                 240 


Gly Ser Thr Leu Ala Phe Phe Val Leu Thr Gly Tyr Lys Phe Gln Pro 
                245                 250                 255     


Thr Gly Asn Asn Pro Tyr Leu Gln Leu Pro Gln Glu Asp Glu Glu Asp 
            260                 265                 270         


Val Gln Met Glu Gln Val Met Thr Asp Ser Gly Phe Arg Glu Gly Leu 
        275                 280                 285             


Ser Lys Val Asn Lys Thr Ala Ser Gly Arg Glu Leu Leu 
    290                 295                 300     


<210>  3682
<211>  2007
<212>  DNA
<213>  Homosapiens

<400>  3682
gggcgccaga ggcggagtcg gggaggaggt ggctccagag atggcagtga gcgagaggag     60

ggggctcggc cgcgggagcc ccgcggagtg ggggcagcgg ctacttctgg tgctgctgct    120

gggtggctgc tccgggcgca tccaccagct ggcgctgacg ggggagaagc gagcggacat    180

ccagctgaac agcttcggtt tctacaccaa tggctctctg gaggtggagt tgagcgtcct    240

gcggctgggc ctccgggagg cagaagagaa gtccctgctg gtggggttca gtctcagccg    300

ggttcggtct ggcagagttc gctcctattc aacccgggat ttccaggact gccctctcca    360

gaaaaacagt agcagtttcc tggtcctgtt cctcatcaac accaaggatc tgcaggtcca    420

ggtgcggaag tatggagagc agaagacgtt gtttatcttt cccgggctcc tcccggaagc    480

accctccaaa ccagggctcc cgaagccaca ggccacagtc ccccgcaagg tggatggcgg    540

agggacctct gcagccagca agcccaagtc aacacccgca gtgattcagg gtcctagtgg    600

gaaggacaag gacctggtgt tgggcctgag ccacctcaac aactcctaca acttcagttt    660

ccacgtggtg atcggctctc aggcggaaga aggccagtac agcctgaact tccacaactg    720

caacaattca gtgccaggaa aggagcatcc attcgacatc acggtgatga tccgggagaa    780

gaaccccgat ggcttcctgt cggcagcgga gatgcccctt ttcaagctct acatggtcat    840

gtccgcctgc ttcctggccg ctggcatctt ctgggtgtcc atcctctgca ggaacacgta    900

cagcgtcttc aagatccact ggctcatggc ggccttggcc ttcaccaaga gcatctctct    960

cctcttccac agcatcaact actacttcat caacagccag ggccacccca tcgaaggcct   1020

tgccgtcatg tactacatcg cacacctgct gaagggcgcc ctcctcttca tcaccatcgc   1080

cctgattggc tcaggctggg ccttcatcaa gtacgtcctg tcggataagg agaagaaggt   1140

ctttgggatc gtgatcccca tgcaggtcct ggccaacgtg gcctacatca tcatcgagtc   1200

ccgcgaggaa ggcgccagcg actacgtgct gtggaaggag attttgttcc tggtggacct   1260

catctgctgt ggtgccatcc tgttccccgt agtctggtcc atccggcatc tccaggatgc   1320

gtctggcaca gacgggaagg tggcagtgaa cctggccaag ctgaagctgt tccggcatta   1380

ctatgtcatg gtcatctgct acgtctactt cacccgcatc atcgccatcc tgctgcaggt   1440

ggctgtgccc tttcagtggc agtggctgta ccagcccaca ggaaacaacc cgtacctgca   1500

gctgccccag gaggacgagg aggatgttca gatggagcaa gtaatgacgg actctgggtt   1560

ccgggaaggc ctctccaaag tcaacaaaac agccagcggg cgggaactgt tatgatcacc   1620

tccacatctc agaccaaagg gtcgtcctcc cccagcattt ctcactcctg cccttcttcc   1680

acagcgtatg tggggaggtg gagggggtcc atgtggacca ggcgcccagc tccccgggac   1740

cccggttccc ggacaagccc atttggaaga agagtccctt cctcccccca aatattgggc   1800

agccctgtcc ttaccccggg accacccctc ccttccagct atgtgtacaa taatgaccaa   1860

tctgtttggc tacgccgttg tcttgccttt ttgggggttg gggtctacac ggaggttgtg   1920

tttacaatgt agaaacctgt tttcgctgtg tgtggcgggg gcgcgggcac agggtccgtg   1980

tctttgtata ttcaataaat attcatt                                       2007


<210>  3683
<211>  524
<212>  PRT
<213>  Homosapiens

<400>  3683

Met Ala Val Ser Glu Arg Arg Gly Leu Gly Arg Gly Ser Pro Ala Glu 
1               5                   10                  15      


Trp Gly Gln Arg Leu Leu Leu Val Leu Leu Leu Gly Gly Cys Ser Gly 
            20                  25                  30          


Arg Ile His Gln Leu Ala Leu Thr Gly Glu Lys Arg Ala Asp Ile Gln 
        35                  40                  45              


Leu Asn Ser Phe Gly Phe Tyr Thr Asn Gly Ser Leu Glu Val Glu Leu 
    50                  55                  60                  


Ser Val Leu Arg Leu Gly Leu Arg Glu Ala Glu Glu Lys Ser Leu Leu 
65                  70                  75                  80  


Val Gly Phe Ser Leu Ser Arg Val Arg Ser Gly Arg Val Arg Ser Tyr 
                85                  90                  95      


Ser Thr Arg Asp Phe Gln Asp Cys Pro Leu Gln Lys Asn Ser Ser Ser 
            100                 105                 110         


Phe Leu Val Leu Phe Leu Ile Asn Thr Lys Asp Leu Gln Val Gln Val 
        115                 120                 125             


Arg Lys Tyr Gly Glu Gln Lys Thr Leu Phe Ile Phe Pro Gly Leu Leu 
    130                 135                 140                 


Pro Glu Ala Pro Ser Lys Pro Gly Leu Pro Lys Pro Gln Ala Thr Val 
145                 150                 155                 160 


Pro Arg Lys Val Asp Gly Gly Gly Thr Ser Ala Ala Ser Lys Pro Lys 
                165                 170                 175     


Ser Thr Pro Ala Val Ile Gln Gly Pro Ser Gly Lys Asp Lys Asp Leu 
            180                 185                 190         


Val Leu Gly Leu Ser His Leu Asn Asn Ser Tyr Asn Phe Ser Phe His 
        195                 200                 205             


Val Val Ile Gly Ser Gln Ala Glu Glu Gly Gln Tyr Ser Leu Asn Phe 
    210                 215                 220                 


His Asn Cys Asn Asn Ser Val Pro Gly Lys Glu His Pro Phe Asp Ile 
225                 230                 235                 240 


Thr Val Met Ile Arg Glu Lys Asn Pro Asp Gly Phe Leu Ser Ala Ala 
                245                 250                 255     


Glu Met Pro Leu Phe Lys Leu Tyr Met Val Met Ser Ala Cys Phe Leu 
            260                 265                 270         


Ala Ala Gly Ile Phe Trp Val Ser Ile Leu Cys Arg Asn Thr Tyr Ser 
        275                 280                 285             


Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Ala Phe Thr Lys Ser 
    290                 295                 300                 


Ile Ser Leu Leu Phe His Ser Ile Asn Tyr Tyr Phe Ile Asn Ser Gln 
305                 310                 315                 320 


Gly His Pro Ile Glu Gly Leu Ala Val Met Tyr Tyr Ile Ala His Leu 
                325                 330                 335     


Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly Ser Gly 
            340                 345                 350         


Trp Ala Phe Ile Lys Tyr Val Leu Ser Asp Lys Glu Lys Lys Val Phe 
        355                 360                 365             


Gly Ile Val Ile Pro Met Gln Val Leu Ala Asn Val Ala Tyr Ile Ile 
    370                 375                 380                 


Ile Glu Ser Arg Glu Glu Gly Ala Ser Asp Tyr Val Leu Trp Lys Glu 
385                 390                 395                 400 


Ile Leu Phe Leu Val Asp Leu Ile Cys Cys Gly Ala Ile Leu Phe Pro 
                405                 410                 415     


Val Val Trp Ser Ile Arg His Leu Gln Asp Ala Ser Gly Thr Asp Gly 
            420                 425                 430         


Lys Val Ala Val Asn Leu Ala Lys Leu Lys Leu Phe Arg His Tyr Tyr 
        435                 440                 445             


Val Met Val Ile Cys Tyr Val Tyr Phe Thr Arg Ile Ile Ala Ile Leu 
    450                 455                 460                 


Leu Gln Val Ala Val Pro Phe Gln Trp Gln Trp Leu Tyr Gln Pro Thr 
465                 470                 475                 480 


Gly Asn Asn Pro Tyr Leu Gln Leu Pro Gln Glu Asp Glu Glu Asp Val 
                485                 490                 495     


Gln Met Glu Gln Val Met Thr Asp Ser Gly Phe Arg Glu Gly Leu Ser 
            500                 505                 510         


Lys Val Asn Lys Thr Ala Ser Gly Arg Glu Leu Leu 
        515                 520                 


<210>  3684
<211>  2029
<212>  DNA
<213>  Homosapiens

<400>  3684
ggcggcgggc ggcgggcggc ggggaccggg tgcggtggtg gctgcggcgg cggcggcggg     60

agcagcatgg attggggcac tgagctgtgg gatcagttcg aggtgctcga gcgccacacg    120

cagtgggggc tggacctgtt ggacagatat gtaaagttcg tgaaagaacg caccgaagtg    180

gaacaggctt acgccaaaca actgcggagc ctggtgaaaa aatatctgcc caagagacct    240

gccaaggatg atcctgagtc caaattcagc cagcaacagt ccttcgtaca gattctccag    300

gaggtgaatg actttgcagg ccagcgggag ctggtggctg agaacctcag tgtccgtgta    360

tgtcttgagc tgaccaagta ctcacaagag atgaaacagg agaggaagat gcacttccaa    420

gaagggcggc gggcccagca gcagctggaa aatggcttta aacagctgga gaatagtaag    480

cgtaaatttg agcgggactg ccgggaggca gagaaggcag cccagactgc tgaacggcta    540

gaccaggata tcaacgccac caaggctgat gtggagaagg ccaagcagca agcccacctt    600

cggagtcaca tggccgaaga aagcaaaaac gaatatgcgg ctcaactgca gcgcttcaac    660

cgagaccaag cccacttcta tttttcacag atgccccaga tattcgataa gctccaagac    720

atggatgaac gcagggccac ccgcctgggt gccgggtatg ggctcctgtc ggaggccgag    780

ctggaggtgg tgcccataat agccaagtgc ttggagggca tgaaggtggc tgcaaatgct    840

gtggatccca agaacgactc ccacgtcctt atagagctgc acaagtcagg ttttgcccgc    900

ccgggcgacg tggaattcga ggacttcagc cagcccatga accgtgcacc ctccgacagc    960

agtctgggca ccccctcgga tggacggcct gaactccgag gcccgggtcg cagccgcacc   1020

aagcgctggc cttttggcaa gaagaacaag acagtggtga ccgaggattt tagccacttg   1080

cccccagagc agcagcgaaa acggcttcaa cagcagttgg aagaacgcag tcgtgaactt   1140

cagaaggagg ttgaccagag ggaagcccta aagaaaatga aggatgtcta tgagaagaca   1200

cctcagatgg gggaccccgc cagcttggag ccccagatcg ctgaaaccct gagcaacatt   1260

gaacggctga aattggaagt gcagaagtat gaggcgtggc tggcagaagc tgaaagtcga   1320

gtccttagca accggggaga cagcctgagc cggcacgccc ggcctcccga cccccccgct   1380

agcgccccgc cagacagcag cagcaacagc gcatcacagg acaccaagga gagctctgaa   1440

gagcctccct cagaagagag ccaggacacc cccatttaca cggagtttga tgaggatttc   1500

gaggaggaac ccacatcccc cataggtcac tgtgtggcca tctaccactt tgaagggtcc   1560

agcgagggca ctatctctat ggccgagggt gaagacctca gtcttatgga agaagacaaa   1620

ggggacggct ggacccgggt caggcggaaa gagggaggcg agggctacgt gcccacctcc   1680

tacctccgag tcacgctcaa ttgaaccctg ccagagacgg gaagaggggg gctgtcggct   1740

gctgcttctg ggccacgggg agccccagga cctatgcact ttatttctga ccccgtggct   1800

tcggctgaga cctgtgtaac ctgctgcccc ctccaccccc aacccagtcc tacctgtcac   1860

accggacgga cccgctgtgc cttctaccat cgttccacca ttgatgtaca tactcatgtt   1920

ttacatcttt tctttctgcc gctcggctcc ggccattttg ttttatacaa aaatgggaaa   1980

aaaaaaaaag aaattatata aagttcctag aaaaaaaaaa aaaaaaaaa               2029


<210>  3685
<211>  545
<212>  PRT
<213>  Homosapiens

<400>  3685

Met Asp Trp Gly Thr Glu Leu Trp Asp Gln Phe Glu Val Leu Glu Arg 
1               5                   10                  15      


His Thr Gln Trp Gly Leu Asp Leu Leu Asp Arg Tyr Val Lys Phe Val 
            20                  25                  30          


Lys Glu Arg Thr Glu Val Glu Gln Ala Tyr Ala Lys Gln Leu Arg Ser 
        35                  40                  45              


Leu Val Lys Lys Tyr Leu Pro Lys Arg Pro Ala Lys Asp Asp Pro Glu 
    50                  55                  60                  


Ser Lys Phe Ser Gln Gln Gln Ser Phe Val Gln Ile Leu Gln Glu Val 
65                  70                  75                  80  


Asn Asp Phe Ala Gly Gln Arg Glu Leu Val Ala Glu Asn Leu Ser Val 
                85                  90                  95      


Arg Val Cys Leu Glu Leu Thr Lys Tyr Ser Gln Glu Met Lys Gln Glu 
            100                 105                 110         


Arg Lys Met His Phe Gln Glu Gly Arg Arg Ala Gln Gln Gln Leu Glu 
        115                 120                 125             


Asn Gly Phe Lys Gln Leu Glu Asn Ser Lys Arg Lys Phe Glu Arg Asp 
    130                 135                 140                 


Cys Arg Glu Ala Glu Lys Ala Ala Gln Thr Ala Glu Arg Leu Asp Gln 
145                 150                 155                 160 


Asp Ile Asn Ala Thr Lys Ala Asp Val Glu Lys Ala Lys Gln Gln Ala 
                165                 170                 175     


His Leu Arg Ser His Met Ala Glu Glu Ser Lys Asn Glu Tyr Ala Ala 
            180                 185                 190         


Gln Leu Gln Arg Phe Asn Arg Asp Gln Ala His Phe Tyr Phe Ser Gln 
        195                 200                 205             


Met Pro Gln Ile Phe Asp Lys Leu Gln Asp Met Asp Glu Arg Arg Ala 
    210                 215                 220                 


Thr Arg Leu Gly Ala Gly Tyr Gly Leu Leu Ser Glu Ala Glu Leu Glu 
225                 230                 235                 240 


Val Val Pro Ile Ile Ala Lys Cys Leu Glu Gly Met Lys Val Ala Ala 
                245                 250                 255     


Asn Ala Val Asp Pro Lys Asn Asp Ser His Val Leu Ile Glu Leu His 
            260                 265                 270         


Lys Ser Gly Phe Ala Arg Pro Gly Asp Val Glu Phe Glu Asp Phe Ser 
        275                 280                 285             


Gln Pro Met Asn Arg Ala Pro Ser Asp Ser Ser Leu Gly Thr Pro Ser 
    290                 295                 300                 


Asp Gly Arg Pro Glu Leu Arg Gly Pro Gly Arg Ser Arg Thr Lys Arg 
305                 310                 315                 320 


Trp Pro Phe Gly Lys Lys Asn Lys Thr Val Val Thr Glu Asp Phe Ser 
                325                 330                 335     


His Leu Pro Pro Glu Gln Gln Arg Lys Arg Leu Gln Gln Gln Leu Glu 
            340                 345                 350         


Glu Arg Ser Arg Glu Leu Gln Lys Glu Val Asp Gln Arg Glu Ala Leu 
        355                 360                 365             


Lys Lys Met Lys Asp Val Tyr Glu Lys Thr Pro Gln Met Gly Asp Pro 
    370                 375                 380                 


Ala Ser Leu Glu Pro Gln Ile Ala Glu Thr Leu Ser Asn Ile Glu Arg 
385                 390                 395                 400 


Leu Lys Leu Glu Val Gln Lys Tyr Glu Ala Trp Leu Ala Glu Ala Glu 
                405                 410                 415     


Ser Arg Val Leu Ser Asn Arg Gly Asp Ser Leu Ser Arg His Ala Arg 
            420                 425                 430         


Pro Pro Asp Pro Pro Ala Ser Ala Pro Pro Asp Ser Ser Ser Asn Ser 
        435                 440                 445             


Ala Ser Gln Asp Thr Lys Glu Ser Ser Glu Glu Pro Pro Ser Glu Glu 
    450                 455                 460                 


Ser Gln Asp Thr Pro Ile Tyr Thr Glu Phe Asp Glu Asp Phe Glu Glu 
465                 470                 475                 480 


Glu Pro Thr Ser Pro Ile Gly His Cys Val Ala Ile Tyr His Phe Glu 
                485                 490                 495     


Gly Ser Ser Glu Gly Thr Ile Ser Met Ala Glu Gly Glu Asp Leu Ser 
            500                 505                 510         


Leu Met Glu Glu Asp Lys Gly Asp Gly Trp Thr Arg Val Arg Arg Lys 
        515                 520                 525             


Glu Gly Gly Glu Gly Tyr Val Pro Thr Ser Tyr Leu Arg Val Thr Leu 
    530                 535                 540                 


Asn 
545 


<210>  3686
<211>  2327
<212>  DNA
<213>  Homosapiens

<400>  3686
cgggggtgac agcagcccgg agccgcggag cctcagcttc cgcctggacc cagcctcgtg     60

ggagccccgc gggtcctgcc cagatgtgga agactgaggc ctgttgaaag tgcagagctc    120

agccctggca ccctctgttc ccaagagctc catgcaggtg ccacaggatg gagaagacct    180

tgctggccaa ccctggtacc acggcctcct gtcccgccag aaggctgaag ctcttcttca    240

gcaagatggc gacttcctgg ttcgcgcctc tgggtcccgt gggggcaacc ccgtgatctc    300

ctgccgctgg cggggctcag ccctccattt tgaggtgttc cgtgtggccc tgcgtccccg    360

gccaggccga cccacagccc tctttcaact ggaggatgag caattcccca gcataccggc    420

tctggttcac agttatatga caggcaggcg cccactgtcc caggccacag gggctgtggt    480

ctccaggcct gtgacttggc aggggcctct gcgacgcagc tttagcgagg acaccctgat    540

ggatggccca gctcggatag agcctctcag ggcaaggaag tggagcaaca gtcagcctgc    600

agatttggca catatggggc ggtcaagaga agaccccgct gggatggaag cctccaccat    660

gcccatatct gccttgcccc gaacgagcag tgacccggtg ttgctgaagg cccctgctcc    720

cctgggaact gttgccgaca gtctcagggc ctccgatggg cagcttcaag ccaaggcacc    780

aacgaagccc ccccggacac cctccttcga actgcctgat gcctctgaac gtcccccgac    840

gtactgcgag ctggtgcccc gagtgcccag tgtccaggga acatccccga gccaaagctg    900

cccagagcca gaggccccat ggtgggaggc cgaggaggat gaggaggaag agaatagatg    960

ttttacaaga ccacaggctg agatctcttt ctgcccccat gatgccccct cctgcctgct   1020

gggcccccag aatcggcccc tggaacccca agtcctgcat accctccgtg gcctgttcct   1080

ggagcaccat cctgggagca ccgcccttca cctgctattg gtagactgcc aggccacagg   1140

cctcctggga gtgaccagag atcagcgggg caacatggga gtctcatctg gcctggagct   1200

gctcactctt ccccatggac accacttgag gttggaactg ctggagaggc atcagacact   1260

ggcgctggcc ggggcgctgg cggtgctggg ctgctcgggg ccgctggagg agcgcgcagc   1320

cgcactgagg ggactggtag agctggcgct ggcgctgcgg ccaggggcgg cgggggacct   1380

gcccgggctg gctgcagtca tgggcgccct gctcatgccc caggtgtccc ggttggagca   1440

cacgtggcgc cagctccgaa ggagccacac ggaggctgcg ctggcctttg agcaggagct   1500

gaagccgctg atgcgggctc tggatgaggg cgctggaccc tgcgaccccg gcgaggtggc   1560

gctgccgcac gtggcaccca tggttcgcct actggagggc gaggaagtcg cggggccgct   1620

ggacgagagc tgtgagcggc tgttgcgcac cctgcacggg gcgcgtcaca tggtccggga   1680

cgcacccaaa ttccgcaagg tggcagccca gcgcctgcga ggattccggc ctaacccgga   1740

gctgagggag gccctgacca ccggcttcgt gcggaggctg ctctggggta gccggggcgc   1800

gggagctccg cgcgctgaac gctttgagaa gttccagcgc gtcctcggcg tcctgtcgca   1860

gcgcctggag cctgaccgct gagagcgcag acacccttct tcacacccgg gacccccagg   1920

tttttgcgaa ccccagaaga gaccaaagga gtcgtcccag gctcctcgcg cctcaggtgg   1980

aatcctgccc tgtgcctcac agaagaggtg gggaccgcag tcagggtcac ctggaccatg   2040

gtgaacatgt gacctgcaga tctggcatca gaggccagag ttcaaatgtg actccacctc   2100

ttaaaagccg tgatttctag cagttgactt cacctctgtg tcggccttta acaaaatcat   2160

agccatacag cagctcaggc ctgtaatctc agcactttgg gaggccgagg cggaaggaag   2220

gcttgaggcc aggagttcaa gaccagccag ggcaacatgg tgagacctca tctctacaaa   2280

aactgaaaaa taaaaaactt ttaaaaaatg taaaaaaaaa aaaaaaa                 2327


<210>  3687
<211>  576
<212>  PRT
<213>  Homosapiens

<400>  3687

Met Gln Val Pro Gln Asp Gly Glu Asp Leu Ala Gly Gln Pro Trp Tyr 
1               5                   10                  15      


His Gly Leu Leu Ser Arg Gln Lys Ala Glu Ala Leu Leu Gln Gln Asp 
            20                  25                  30          


Gly Asp Phe Leu Val Arg Ala Ser Gly Ser Arg Gly Gly Asn Pro Val 
        35                  40                  45              


Ile Ser Cys Arg Trp Arg Gly Ser Ala Leu His Phe Glu Val Phe Arg 
    50                  55                  60                  


Val Ala Leu Arg Pro Arg Pro Gly Arg Pro Thr Ala Leu Phe Gln Leu 
65                  70                  75                  80  


Glu Asp Glu Gln Phe Pro Ser Ile Pro Ala Leu Val His Ser Tyr Met 
                85                  90                  95      


Thr Gly Arg Arg Pro Leu Ser Gln Ala Thr Gly Ala Val Val Ser Arg 
            100                 105                 110         


Pro Val Thr Trp Gln Gly Pro Leu Arg Arg Ser Phe Ser Glu Asp Thr 
        115                 120                 125             


Leu Met Asp Gly Pro Ala Arg Ile Glu Pro Leu Arg Ala Arg Lys Trp 
    130                 135                 140                 


Ser Asn Ser Gln Pro Ala Asp Leu Ala His Met Gly Arg Ser Arg Glu 
145                 150                 155                 160 


Asp Pro Ala Gly Met Glu Ala Ser Thr Met Pro Ile Ser Ala Leu Pro 
                165                 170                 175     


Arg Thr Ser Ser Asp Pro Val Leu Leu Lys Ala Pro Ala Pro Leu Gly 
            180                 185                 190         


Thr Val Ala Asp Ser Leu Arg Ala Ser Asp Gly Gln Leu Gln Ala Lys 
        195                 200                 205             


Ala Pro Thr Lys Pro Pro Arg Thr Pro Ser Phe Glu Leu Pro Asp Ala 
    210                 215                 220                 


Ser Glu Arg Pro Pro Thr Tyr Cys Glu Leu Val Pro Arg Val Pro Ser 
225                 230                 235                 240 


Val Gln Gly Thr Ser Pro Ser Gln Ser Cys Pro Glu Pro Glu Ala Pro 
                245                 250                 255     


Trp Trp Glu Ala Glu Glu Asp Glu Glu Glu Glu Asn Arg Cys Phe Thr 
            260                 265                 270         


Arg Pro Gln Ala Glu Ile Ser Phe Cys Pro His Asp Ala Pro Ser Cys 
        275                 280                 285             


Leu Leu Gly Pro Gln Asn Arg Pro Leu Glu Pro Gln Val Leu His Thr 
    290                 295                 300                 


Leu Arg Gly Leu Phe Leu Glu His His Pro Gly Ser Thr Ala Leu His 
305                 310                 315                 320 


Leu Leu Leu Val Asp Cys Gln Ala Thr Gly Leu Leu Gly Val Thr Arg 
                325                 330                 335     


Asp Gln Arg Gly Asn Met Gly Val Ser Ser Gly Leu Glu Leu Leu Thr 
            340                 345                 350         


Leu Pro His Gly His His Leu Arg Leu Glu Leu Leu Glu Arg His Gln 
        355                 360                 365             


Thr Leu Ala Leu Ala Gly Ala Leu Ala Val Leu Gly Cys Ser Gly Pro 
    370                 375                 380                 


Leu Glu Glu Arg Ala Ala Ala Leu Arg Gly Leu Val Glu Leu Ala Leu 
385                 390                 395                 400 


Ala Leu Arg Pro Gly Ala Ala Gly Asp Leu Pro Gly Leu Ala Ala Val 
                405                 410                 415     


Met Gly Ala Leu Leu Met Pro Gln Val Ser Arg Leu Glu His Thr Trp 
            420                 425                 430         


Arg Gln Leu Arg Arg Ser His Thr Glu Ala Ala Leu Ala Phe Glu Gln 
        435                 440                 445             


Glu Leu Lys Pro Leu Met Arg Ala Leu Asp Glu Gly Ala Gly Pro Cys 
    450                 455                 460                 


Asp Pro Gly Glu Val Ala Leu Pro His Val Ala Pro Met Val Arg Leu 
465                 470                 475                 480 


Leu Glu Gly Glu Glu Val Ala Gly Pro Leu Asp Glu Ser Cys Glu Arg 
                485                 490                 495     


Leu Leu Arg Thr Leu His Gly Ala Arg His Met Val Arg Asp Ala Pro 
            500                 505                 510         


Lys Phe Arg Lys Val Ala Ala Gln Arg Leu Arg Gly Phe Arg Pro Asn 
        515                 520                 525             


Pro Glu Leu Arg Glu Ala Leu Thr Thr Gly Phe Val Arg Arg Leu Leu 
    530                 535                 540                 


Trp Gly Ser Arg Gly Ala Gly Ala Pro Arg Ala Glu Arg Phe Glu Lys 
545                 550                 555                 560 


Phe Gln Arg Val Leu Gly Val Leu Ser Gln Arg Leu Glu Pro Asp Arg 
                565                 570                 575     


<210>  3688
<211>  2888
<212>  DNA
<213>  Homosapiens

<400>  3688
actagctgtc gctccacagg cgagcagggc aggcgtgcgg gcgggtgggt ggtggaggct     60

gcgagggtgc acggccggcc ctgggcaggc ggtagccatg gagctgtggc gccaatgcac    120

ccactggctc atccagtgcc gggtgctgcc gcccagccac cgcgtgacct gggatggggc    180

tcaggtgtgt gaactggccc aggccctccg ggatggtgtc cttctgtgtc agctgcttaa    240

caacctgcta ccccatgcca tcaacctgcg tgaggtcaac ctgcgccccc agatgtccca    300

gttcctgtgc cttaagaaca ttagaacctt cctgtccacc tgctgtgaga agttcggcct    360

caagcggagc gagctcttcg aagcctttga cctcttcgat gtgcaggatt ttggcaaggt    420

catctacacc ctgtctgctc tgtcctggac cccgatcgcc cagaacaggg ggatcatgcc    480

cttccccacc gaggaggaga gtgtaggtga tgaagacatc tacagtggcc tgtccgacca    540

gatcgacgac acggtggagg aggatgagga cctgtatgac tgcgtggaga atgaggaggc    600

ggaaggcgac gagatctatg aggacctcat gcgctcggag cccgtgtcca tgccgcccaa    660

gatgacagag tatgacaagc gctgctgctg cctgcgggag atccagcaga cggaggagaa    720

gtacactgac acgctgggct ccatccagca gcatttcttg aagcccctgc aacggttcct    780

gaaacctcaa gacattgaga tcatctttat caacattgag gacctgcttc gtgttcatac    840

tcacttccta aaggagatga aggaagccct gggcacccct ggcgcagcca atctctacca    900

ggtcttcatc aaatacaagg agaggttcct cgtctatggc cgctactgca gccaggtgga    960

gtcagccagc aaacacctgg accgtgtggc cgcagcccgg gaggacgtgc agatgaagct   1020

ggaggaatgt tctcagagag ccaacaacgg gaggttcacc ctgcgggacc tgctgatggt   1080

gcctatgcag cgagttctca aatatcacct ccttctccag gagctggtga aacacacgca   1140

ggaggcgatg gagaaggaga acctgcggct ggccctggat gccatgaggg acctggctca   1200

gtgcgtgaac gaggtcaagc gagacaacga gacactgcga cagatcacca atttccagct   1260

gtccattgag aacctggacc agtctctggc tcactatggc cggcccaaga tcgacgggga   1320

actcaagatc acctcggtgg aacggcgctc caagatggac aggtatgcct tcctgctcga   1380

caaagctcta ctcatctgta agcgcagggg agactcctat gacctcaagg actttgtaaa   1440

cctgcacagc ttccaggttc gggatgactc ttcaggagac cgagacaaca agaagtggag   1500

ccacatgttc ctcctgatcg aggaccaagg tgcccagggc tatgagctgt tcttcaagac   1560

aagagaattg aagaagaagt ggatggagca gtttgagatg gccatctcca acatctatcc   1620

ggagaatgcc accgccaacg ggcatgactt ccagatgttc tcctttgagg agaccacatc   1680

ctgcaaggcc tgtcagatgc tgcttagagg taccttctat cagggctacc gctgccatcg   1740

gtgccgggca tctgcacaca aggagtgtct ggggagggtc cctccatgtg gccgacatgg   1800

gcaagatttc ccaggaacta tgaagaagga caaactacat cgcagggctc aggacaaaaa   1860

gaggaatgag ctgggtctgc ccaagatgga ggtgtttcag gaatactacg ggcttcctcc   1920

accccctgga gccattggac cctttctacg gctcaaccct ggagacattg tggagctcac   1980

gaaggctgag gctgaacaga actggtggga gggcagaaat acatctacta atgaaattgg   2040

ctggtttcct tgtaacaggg tgaagcccta tgtccatggc cctcctcagg acctgtctgt   2100

tcatctctgg tacgcaggcc ccatggagcg ggcaggggca gagagcatcc tggccaaccg   2160

ctcggacggg actttcttgg tgcggcagag ggtgaaggat gcagcagaat ttgccatcag   2220

cattaaatat aacgtcgagg tcaagcacat taaaatcatg acagcagaag gactgtaccg   2280

gatcacagag aaaaaggctt tccgggggct tacggagctg gtggagtttt accagcagaa   2340

ctctctaaag gattgcttca agtctctgga caccaccttg cagttcccct tcaaggagcc   2400

tgaaaagaga accatcagca ggccagcagt gggaagcaca aagtattttg gcacagccaa   2460

agcccgctat gacttctgcg cccgagaccg atcagagctg tcgctcaagg agggtgacat   2520

catcaagatc cttaacaaga agggacagca aggctggtgg cgaggggaga tctatggccg   2580

ggttggctgg ttccctgcca actacgtgga ggaagattat tctgaatact gctgagccct   2640

ggtgccttgg cagagagacg agaaactcca ggctctgagc ccggcgtggg caggcagcgg   2700

agccaggggc tgtgacagct cccggcgggt ggagactttg ggatggactg gaggagcgca   2760

gcgtccagct ggcggtgctc ccgggatgtg ccctgacatg gttaatttat aacaccccga   2820

tttcctcttg ggtcccctca agcagacggg gctcaagggg gttacattta ataaaaggat   2880

gaagatgg                                                            2888


<210>  3689
<211>  845
<212>  PRT
<213>  Homosapiens

<400>  3689

Met Glu Leu Trp Arg Gln Cys Thr His Trp Leu Ile Gln Cys Arg Val 
1               5                   10                  15      


Leu Pro Pro Ser His Arg Val Thr Trp Asp Gly Ala Gln Val Cys Glu 
            20                  25                  30          


Leu Ala Gln Ala Leu Arg Asp Gly Val Leu Leu Cys Gln Leu Leu Asn 
        35                  40                  45              


Asn Leu Leu Pro His Ala Ile Asn Leu Arg Glu Val Asn Leu Arg Pro 
    50                  55                  60                  


Gln Met Ser Gln Phe Leu Cys Leu Lys Asn Ile Arg Thr Phe Leu Ser 
65                  70                  75                  80  


Thr Cys Cys Glu Lys Phe Gly Leu Lys Arg Ser Glu Leu Phe Glu Ala 
                85                  90                  95      


Phe Asp Leu Phe Asp Val Gln Asp Phe Gly Lys Val Ile Tyr Thr Leu 
            100                 105                 110         


Ser Ala Leu Ser Trp Thr Pro Ile Ala Gln Asn Arg Gly Ile Met Pro 
        115                 120                 125             


Phe Pro Thr Glu Glu Glu Ser Val Gly Asp Glu Asp Ile Tyr Ser Gly 
    130                 135                 140                 


Leu Ser Asp Gln Ile Asp Asp Thr Val Glu Glu Asp Glu Asp Leu Tyr 
145                 150                 155                 160 


Asp Cys Val Glu Asn Glu Glu Ala Glu Gly Asp Glu Ile Tyr Glu Asp 
                165                 170                 175     


Leu Met Arg Ser Glu Pro Val Ser Met Pro Pro Lys Met Thr Glu Tyr 
            180                 185                 190         


Asp Lys Arg Cys Cys Cys Leu Arg Glu Ile Gln Gln Thr Glu Glu Lys 
        195                 200                 205             


Tyr Thr Asp Thr Leu Gly Ser Ile Gln Gln His Phe Leu Lys Pro Leu 
    210                 215                 220                 


Gln Arg Phe Leu Lys Pro Gln Asp Ile Glu Ile Ile Phe Ile Asn Ile 
225                 230                 235                 240 


Glu Asp Leu Leu Arg Val His Thr His Phe Leu Lys Glu Met Lys Glu 
                245                 250                 255     


Ala Leu Gly Thr Pro Gly Ala Ala Asn Leu Tyr Gln Val Phe Ile Lys 
            260                 265                 270         


Tyr Lys Glu Arg Phe Leu Val Tyr Gly Arg Tyr Cys Ser Gln Val Glu 
        275                 280                 285             


Ser Ala Ser Lys His Leu Asp Arg Val Ala Ala Ala Arg Glu Asp Val 
    290                 295                 300                 


Gln Met Lys Leu Glu Glu Cys Ser Gln Arg Ala Asn Asn Gly Arg Phe 
305                 310                 315                 320 


Thr Leu Arg Asp Leu Leu Met Val Pro Met Gln Arg Val Leu Lys Tyr 
                325                 330                 335     


His Leu Leu Leu Gln Glu Leu Val Lys His Thr Gln Glu Ala Met Glu 
            340                 345                 350         


Lys Glu Asn Leu Arg Leu Ala Leu Asp Ala Met Arg Asp Leu Ala Gln 
        355                 360                 365             


Cys Val Asn Glu Val Lys Arg Asp Asn Glu Thr Leu Arg Gln Ile Thr 
    370                 375                 380                 


Asn Phe Gln Leu Ser Ile Glu Asn Leu Asp Gln Ser Leu Ala His Tyr 
385                 390                 395                 400 


Gly Arg Pro Lys Ile Asp Gly Glu Leu Lys Ile Thr Ser Val Glu Arg 
                405                 410                 415     


Arg Ser Lys Met Asp Arg Tyr Ala Phe Leu Leu Asp Lys Ala Leu Leu 
            420                 425                 430         


Ile Cys Lys Arg Arg Gly Asp Ser Tyr Asp Leu Lys Asp Phe Val Asn 
        435                 440                 445             


Leu His Ser Phe Gln Val Arg Asp Asp Ser Ser Gly Asp Arg Asp Asn 
    450                 455                 460                 


Lys Lys Trp Ser His Met Phe Leu Leu Ile Glu Asp Gln Gly Ala Gln 
465                 470                 475                 480 


Gly Tyr Glu Leu Phe Phe Lys Thr Arg Glu Leu Lys Lys Lys Trp Met 
                485                 490                 495     


Glu Gln Phe Glu Met Ala Ile Ser Asn Ile Tyr Pro Glu Asn Ala Thr 
            500                 505                 510         


Ala Asn Gly His Asp Phe Gln Met Phe Ser Phe Glu Glu Thr Thr Ser 
        515                 520                 525             


Cys Lys Ala Cys Gln Met Leu Leu Arg Gly Thr Phe Tyr Gln Gly Tyr 
    530                 535                 540                 


Arg Cys His Arg Cys Arg Ala Ser Ala His Lys Glu Cys Leu Gly Arg 
545                 550                 555                 560 


Val Pro Pro Cys Gly Arg His Gly Gln Asp Phe Pro Gly Thr Met Lys 
                565                 570                 575     


Lys Asp Lys Leu His Arg Arg Ala Gln Asp Lys Lys Arg Asn Glu Leu 
            580                 585                 590         


Gly Leu Pro Lys Met Glu Val Phe Gln Glu Tyr Tyr Gly Leu Pro Pro 
        595                 600                 605             


Pro Pro Gly Ala Ile Gly Pro Phe Leu Arg Leu Asn Pro Gly Asp Ile 
    610                 615                 620                 


Val Glu Leu Thr Lys Ala Glu Ala Glu Gln Asn Trp Trp Glu Gly Arg 
625                 630                 635                 640 


Asn Thr Ser Thr Asn Glu Ile Gly Trp Phe Pro Cys Asn Arg Val Lys 
                645                 650                 655     


Pro Tyr Val His Gly Pro Pro Gln Asp Leu Ser Val His Leu Trp Tyr 
            660                 665                 670         


Ala Gly Pro Met Glu Arg Ala Gly Ala Glu Ser Ile Leu Ala Asn Arg 
        675                 680                 685             


Ser Asp Gly Thr Phe Leu Val Arg Gln Arg Val Lys Asp Ala Ala Glu 
    690                 695                 700                 


Phe Ala Ile Ser Ile Lys Tyr Asn Val Glu Val Lys His Ile Lys Ile 
705                 710                 715                 720 


Met Thr Ala Glu Gly Leu Tyr Arg Ile Thr Glu Lys Lys Ala Phe Arg 
                725                 730                 735     


Gly Leu Thr Glu Leu Val Glu Phe Tyr Gln Gln Asn Ser Leu Lys Asp 
            740                 745                 750         


Cys Phe Lys Ser Leu Asp Thr Thr Leu Gln Phe Pro Phe Lys Glu Pro 
        755                 760                 765             


Glu Lys Arg Thr Ile Ser Arg Pro Ala Val Gly Ser Thr Lys Tyr Phe 
    770                 775                 780                 


Gly Thr Ala Lys Ala Arg Tyr Asp Phe Cys Ala Arg Asp Arg Ser Glu 
785                 790                 795                 800 


Leu Ser Leu Lys Glu Gly Asp Ile Ile Lys Ile Leu Asn Lys Lys Gly 
                805                 810                 815     


Gln Gln Gly Trp Trp Arg Gly Glu Ile Tyr Gly Arg Val Gly Trp Phe 
            820                 825                 830         


Pro Ala Asn Tyr Val Glu Glu Asp Tyr Ser Glu Tyr Cys 
        835                 840                 845 


<210>  3690
<211>  4691
<212>  DNA
<213>  Homosapiens

<400>  3690
gagaaggacg cgcggccccc agcgctcttg ggggccgcct cggagcatga cccccgcggg     60

ccagcgccgc gcgcctgatc cgaggagacc ccgcgctccc gcagccatgg gcaccggggg    120

ccggcggggg gcggcggccg cgccgctgct ggtggcggtg gccgcgctgc tactgggcgc    180

cgcgggccac ctgtaccccg gagaggtgtg tcccggcatg gatatccgga acaacctcac    240

taggttgcat gagctggaga attgctctgt catcgaagga cacttgcaga tactcttgat    300

gttcaaaacg aggcccgaag atttccgaga cctcagtttc cccaaactca tcatgatcac    360

tgattacttg ctgctcttcc gggtctatgg gctcgagagc ctgaaggacc tgttccccaa    420

cctcacggtc atccggggat cacgactgtt ctttaactac gcgctggtca tcttcgagat    480

ggttcacctc aaggaactcg gcctctacaa cctgatgaac atcacccggg gttctgtccg    540

catcgagaag aacaatgagc tctgttactt ggccactatc gactggtccc gtatcctgga    600

ttccgtggag gataatcaca tcgtgttgaa caaagatgac aacgaggagt gtggagacat    660

ctgtccgggt accgcgaagg gcaagaccaa ctgccccgcc accgtcatca acgggcagtt    720

tgtcgaacga tgttggactc atagtcactg ccagaaagtt tgcccgacca tctgtaagtc    780

acacggctgc accgccgaag gcctctgttg ccacagcgag tgcctgggca actgttctca    840

gcccgacgac cccaccaagt gcgtggcctg ccgcaacttc tacctggacg gcaggtgtgt    900

ggagacctgc ccgcccccgt actaccactt ccaggactgg cgctgtgtga acttcagctt    960

ctgccaggac ctgcaccaca aatgcaagaa ctcgcggagg cagggctgcc accaatacgt   1020

cattcacaac aacaagtgca tccctgagtg tccctccggg tacacgatga attccagcaa   1080

cttgctgtgc accccatgcc tgggtccctg tcccaaggtg tgccacctcc tagaaggcga   1140

gaagaccatc gactcggtga cgtctgccca ggagctccga ggatgcaccg tcatcaacgg   1200

gagtctgatc atcaacattc gaggaggcaa caatctggca gctgagctag aagccaacct   1260

cggcctcatt gaagaaattt cagggtatct aaaaatccgc cgatcctacg ctctggtgtc   1320

actttccttc ttccggaagt tacgtctgat tcgaggagag accttggaaa ttgggaacta   1380

ctccttctat gccttggaca accagaacct aaggcagctc tgggactgga gcaaacacaa   1440

cctcaccacc actcagggga aactcttctt ccactataac cccaaactct gcttgtcaga   1500

aatccacaag atggaagaag tttcaggaac caaggggcgc caggagagaa acgacattgc   1560

cctgaagacc aatggggaca aggcatcctg tgaaaatgag ttacttaaat tttcttacat   1620

tcggacatct tttgacaaga tcttgctgag atgggagccg tactggcccc ccgacttccg   1680

agacctcttg gggttcatgc tgttctacaa agaggcccct tatcagaatg tgacggagtt   1740

cgatgggcag gatgcgtgtg gttccaacag ttggacggtg gtagacattg acccacccct   1800

gaggtccaac gaccccaaat cacagaacca cccagggtgg ctgatgcggg gtctcaagcc   1860

ctggacccag tatgccatct ttgtgaagac cctggtcacc ttttcggatg aacgccggac   1920

ctatggggcc aagagtgaca tcatttatgt ccagacagat gccaccaacc cctctgtgcc   1980

cctggatcca atctcagtgt ctaactcatc atcccagatt attctgaagt ggaaaccacc   2040

ctccgacccc aatggcaaca tcacccacta cctggttttc tgggagaggc aggcggaaga   2100

cagtgagctg ttcgagctgg attattgcct caaagggctg aagctgccct cgaggacctg   2160

gtctccacca ttcgagtctg aagattctca gaagcacaac cagagtgagt atgaggattc   2220

ggccggcgaa tgctgctcct gtccaaagac agactctcag atcctgaagg agctggagga   2280

gtcctcgttt aggaagacgt ttgaggatta cctgcacaac gtggttttcg tccccagaaa   2340

aacctcttca ggcactggtg ccgaggaccc taggccatct cggaaacgca ggtcccttgg   2400

cgatgttggg aatgtgacgg tggccgtgcc cacggtggca gctttcccca acacttcctc   2460

gaccagcgtg cccacgagtc cggaggagca caggcctttt gagaaggtgg tgaacaagga   2520

gtcgctggtc atctccggct tgcgacactt cacgggctat cgcatcgagc tgcaggcttg   2580

caaccaggac acccctgagg aacggtgcag tgtggcagcc tacgtcagtg cgaggaccat   2640

gcctgaagcc aaggctgatg acattgttgg ccctgtgacg catgaaatct ttgagaacaa   2700

cgtcgtccac ttgatgtggc aggagccgaa ggagcccaat ggtctgatcg tgctgtatga   2760

agtgagttat cggcgatatg gtgatgagga gctgcatctc tgcgtctccc gcaagcactt   2820

cgctctggaa cggggctgca ggctgcgtgg gctgtcaccg gggaactaca gcgtgcgaat   2880

ccgggccacc tcccttgcgg gcaacggctc ttggacggaa cccacctatt tctacgtgac   2940

agactattta gacgtcccgt caaatattgc aaaaattatc atcggccccc tcatctttgt   3000

ctttctcttc agtgttgtga ttggaagtat ttatctattc ctgagaaaga ggcagccaga   3060

tgggccgctg ggaccgcttt acgcttcttc aaaccctgag tatctcagtg ccagtgatgt   3120

gtttccatgc tctgtgtacg tgccggacga gtgggaggtg tctcgagaga agatcaccct   3180

ccttcgagag ctggggcagg gctccttcgg catggtgtat gagggcaatg ccagggacat   3240

catcaagggt gaggcagaga cccgcgtggc ggtgaagacg gtcaacgagt cagccagtct   3300

ccgagagcgg attgagttcc tcaatgaggc ctcggtcatg aagggcttca cctgccatca   3360

cgtggtgcgc ctcctgggag tggtgtccaa gggccagccc acgctggtgg tgatggagct   3420

gatggctcac ggagacctga agagctacct ccgttctctg cggccagagg ctgagaataa   3480

tcctggccgc cctcccccta cccttcaaga gatgattcag atggcggcag agattgctga   3540

cgggatggcc tacctgaacg ccaagaagtt tgtgcatcgg gacctggcag cgagaaactg   3600

catggtcgcc catgatttta ctgtcaaaat tggagacttt ggaatgacca gagacatcta   3660

tgaaacggat tactaccgga aagggggcaa gggtctgctc cctgtacggt ggatggcacc   3720

ggagtccctg aaggatgggg tcttcaccac ttcttctgac atgtggtcct ttggcgtggt   3780

cctttgggaa atcaccagct tggcagaaca gccttaccaa ggcctgtcta atgaacaggt   3840

gttgaaattt gtcatggatg gagggtatct ggatcaaccc gacaactgtc cagagagagt   3900

cactgacctc atgcgcatgt gctggcaatt caaccccaag atgaggccaa ccttcctgga   3960

gattgtcaac ctgctcaagg acgacctgca ccccagcttt ccagaggtgt cgttcttcca   4020

cagcgaggag aacaaggctc ccgagagtga ggagctggag atggagtttg aggacatgga   4080

gaatgtgccc ctggaccgtt cctcgcactg tcagagggag gaggcggggg gccgggatgg   4140

agggtcctcg ctgggtttca agcggagcta cgaggaacac atcccttaca cacacatgaa   4200

cggaggcaag aaaaacgggc ggattctgac cttgcctcgg tccaatcctt cctaacagtg   4260

cctaccgtgg cgggggcggg caggggttcc cattttcgct ttcctctggt ttgaaagcct   4320

ctggaaaact caggattctc acgactctac catgtccagt ggagttcaga gatcgttcct   4380

atacatttct gttcatctta aggtggactc gtttggttac caatttaact agtcctgcag   4440

aggatttaac tgtgaacctg gagggcaagg ggtttccaca gttgctgctc ctttggggca   4500

acgacggttt caaaccagga ttttgtgttt tttcgttccc cccacccgcc cccagcagat   4560

ggaaagaaag cacctgtttt tacaaattct tttttttttt tttttttttt tttttttgct   4620

ggtgtctgag cttcagtata aaagacaaaa cttcctgttt gtggaacaaa atttcgaaag   4680

aaaaaaccaa a                                                        4691


<210>  3691
<211>  1382
<212>  PRT
<213>  Homosapiens

<400>  3691

Met Gly Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val 
1               5                   10                  15      


Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly His Leu Tyr Pro Gly 
            20                  25                  30          


Glu Val Cys Pro Gly Met Asp Ile Arg Asn Asn Leu Thr Arg Leu His 
        35                  40                  45              


Glu Leu Glu Asn Cys Ser Val Ile Glu Gly His Leu Gln Ile Leu Leu 
    50                  55                  60                  


Met Phe Lys Thr Arg Pro Glu Asp Phe Arg Asp Leu Ser Phe Pro Lys 
65                  70                  75                  80  


Leu Ile Met Ile Thr Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu 
                85                  90                  95      


Glu Ser Leu Lys Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Ser 
            100                 105                 110         


Arg Leu Phe Phe Asn Tyr Ala Leu Val Ile Phe Glu Met Val His Leu 
        115                 120                 125             


Lys Glu Leu Gly Leu Tyr Asn Leu Met Asn Ile Thr Arg Gly Ser Val 
    130                 135                 140                 


Arg Ile Glu Lys Asn Asn Glu Leu Cys Tyr Leu Ala Thr Ile Asp Trp 
145                 150                 155                 160 


Ser Arg Ile Leu Asp Ser Val Glu Asp Asn His Ile Val Leu Asn Lys 
                165                 170                 175     


Asp Asp Asn Glu Glu Cys Gly Asp Ile Cys Pro Gly Thr Ala Lys Gly 
            180                 185                 190         


Lys Thr Asn Cys Pro Ala Thr Val Ile Asn Gly Gln Phe Val Glu Arg 
        195                 200                 205             


Cys Trp Thr His Ser His Cys Gln Lys Val Cys Pro Thr Ile Cys Lys 
    210                 215                 220                 


Ser His Gly Cys Thr Ala Glu Gly Leu Cys Cys His Ser Glu Cys Leu 
225                 230                 235                 240 


Gly Asn Cys Ser Gln Pro Asp Asp Pro Thr Lys Cys Val Ala Cys Arg 
                245                 250                 255     


Asn Phe Tyr Leu Asp Gly Arg Cys Val Glu Thr Cys Pro Pro Pro Tyr 
            260                 265                 270         


Tyr His Phe Gln Asp Trp Arg Cys Val Asn Phe Ser Phe Cys Gln Asp 
        275                 280                 285             


Leu His His Lys Cys Lys Asn Ser Arg Arg Gln Gly Cys His Gln Tyr 
    290                 295                 300                 


Val Ile His Asn Asn Lys Cys Ile Pro Glu Cys Pro Ser Gly Tyr Thr 
305                 310                 315                 320 


Met Asn Ser Ser Asn Leu Leu Cys Thr Pro Cys Leu Gly Pro Cys Pro 
                325                 330                 335     


Lys Val Cys His Leu Leu Glu Gly Glu Lys Thr Ile Asp Ser Val Thr 
            340                 345                 350         


Ser Ala Gln Glu Leu Arg Gly Cys Thr Val Ile Asn Gly Ser Leu Ile 
        355                 360                 365             


Ile Asn Ile Arg Gly Gly Asn Asn Leu Ala Ala Glu Leu Glu Ala Asn 
    370                 375                 380                 


Leu Gly Leu Ile Glu Glu Ile Ser Gly Tyr Leu Lys Ile Arg Arg Ser 
385                 390                 395                 400 


Tyr Ala Leu Val Ser Leu Ser Phe Phe Arg Lys Leu Arg Leu Ile Arg 
                405                 410                 415     


Gly Glu Thr Leu Glu Ile Gly Asn Tyr Ser Phe Tyr Ala Leu Asp Asn 
            420                 425                 430         


Gln Asn Leu Arg Gln Leu Trp Asp Trp Ser Lys His Asn Leu Thr Thr 
        435                 440                 445             


Thr Gln Gly Lys Leu Phe Phe His Tyr Asn Pro Lys Leu Cys Leu Ser 
    450                 455                 460                 


Glu Ile His Lys Met Glu Glu Val Ser Gly Thr Lys Gly Arg Gln Glu 
465                 470                 475                 480 


Arg Asn Asp Ile Ala Leu Lys Thr Asn Gly Asp Lys Ala Ser Cys Glu 
                485                 490                 495     


Asn Glu Leu Leu Lys Phe Ser Tyr Ile Arg Thr Ser Phe Asp Lys Ile 
            500                 505                 510         


Leu Leu Arg Trp Glu Pro Tyr Trp Pro Pro Asp Phe Arg Asp Leu Leu 
        515                 520                 525             


Gly Phe Met Leu Phe Tyr Lys Glu Ala Pro Tyr Gln Asn Val Thr Glu 
    530                 535                 540                 


Phe Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Thr Val Val Asp 
545                 550                 555                 560 


Ile Asp Pro Pro Leu Arg Ser Asn Asp Pro Lys Ser Gln Asn His Pro 
                565                 570                 575     


Gly Trp Leu Met Arg Gly Leu Lys Pro Trp Thr Gln Tyr Ala Ile Phe 
            580                 585                 590         


Val Lys Thr Leu Val Thr Phe Ser Asp Glu Arg Arg Thr Tyr Gly Ala 
        595                 600                 605             


Lys Ser Asp Ile Ile Tyr Val Gln Thr Asp Ala Thr Asn Pro Ser Val 
    610                 615                 620                 


Pro Leu Asp Pro Ile Ser Val Ser Asn Ser Ser Ser Gln Ile Ile Leu 
625                 630                 635                 640 


Lys Trp Lys Pro Pro Ser Asp Pro Asn Gly Asn Ile Thr His Tyr Leu 
                645                 650                 655     


Val Phe Trp Glu Arg Gln Ala Glu Asp Ser Glu Leu Phe Glu Leu Asp 
            660                 665                 670         


Tyr Cys Leu Lys Gly Leu Lys Leu Pro Ser Arg Thr Trp Ser Pro Pro 
        675                 680                 685             


Phe Glu Ser Glu Asp Ser Gln Lys His Asn Gln Ser Glu Tyr Glu Asp 
    690                 695                 700                 


Ser Ala Gly Glu Cys Cys Ser Cys Pro Lys Thr Asp Ser Gln Ile Leu 
705                 710                 715                 720 


Lys Glu Leu Glu Glu Ser Ser Phe Arg Lys Thr Phe Glu Asp Tyr Leu 
                725                 730                 735     


His Asn Val Val Phe Val Pro Arg Lys Thr Ser Ser Gly Thr Gly Ala 
            740                 745                 750         


Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu Gly Asp Val Gly 
        755                 760                 765             


Asn Val Thr Val Ala Val Pro Thr Val Ala Ala Phe Pro Asn Thr Ser 
    770                 775                 780                 


Ser Thr Ser Val Pro Thr Ser Pro Glu Glu His Arg Pro Phe Glu Lys 
785                 790                 795                 800 


Val Val Asn Lys Glu Ser Leu Val Ile Ser Gly Leu Arg His Phe Thr 
                805                 810                 815     


Gly Tyr Arg Ile Glu Leu Gln Ala Cys Asn Gln Asp Thr Pro Glu Glu 
            820                 825                 830         


Arg Cys Ser Val Ala Ala Tyr Val Ser Ala Arg Thr Met Pro Glu Ala 
        835                 840                 845             


Lys Ala Asp Asp Ile Val Gly Pro Val Thr His Glu Ile Phe Glu Asn 
    850                 855                 860                 


Asn Val Val His Leu Met Trp Gln Glu Pro Lys Glu Pro Asn Gly Leu 
865                 870                 875                 880 


Ile Val Leu Tyr Glu Val Ser Tyr Arg Arg Tyr Gly Asp Glu Glu Leu 
                885                 890                 895     


His Leu Cys Val Ser Arg Lys His Phe Ala Leu Glu Arg Gly Cys Arg 
            900                 905                 910         


Leu Arg Gly Leu Ser Pro Gly Asn Tyr Ser Val Arg Ile Arg Ala Thr 
        915                 920                 925             


Ser Leu Ala Gly Asn Gly Ser Trp Thr Glu Pro Thr Tyr Phe Tyr Val 
    930                 935                 940                 


Thr Asp Tyr Leu Asp Val Pro Ser Asn Ile Ala Lys Ile Ile Ile Gly 
945                 950                 955                 960 


Pro Leu Ile Phe Val Phe Leu Phe Ser Val Val Ile Gly Ser Ile Tyr 
                965                 970                 975     


Leu Phe Leu Arg Lys Arg Gln Pro Asp Gly Pro Leu Gly Pro Leu Tyr 
            980                 985                 990         


Ala Ser Ser Asn Pro Glu Tyr Leu  Ser Ala Ser Asp Val  Phe Pro Cys 
        995                 1000                 1005             


Ser Val  Tyr Val Pro Asp Glu  Trp Glu Val Ser Arg  Glu Lys Ile 
    1010                 1015                 1020             


Thr Leu  Leu Arg Glu Leu Gly  Gln Gly Ser Phe Gly  Met Val Tyr 
    1025                 1030                 1035             


Glu Gly  Asn Ala Arg Asp Ile  Ile Lys Gly Glu Ala  Glu Thr Arg 
    1040                 1045                 1050             


Val Ala  Val Lys Thr Val Asn  Glu Ser Ala Ser Leu  Arg Glu Arg 
    1055                 1060                 1065             


Ile Glu  Phe Leu Asn Glu Ala  Ser Val Met Lys Gly  Phe Thr Cys 
    1070                 1075                 1080             


His His  Val Val Arg Leu Leu  Gly Val Val Ser Lys  Gly Gln Pro 
    1085                 1090                 1095             


Thr Leu  Val Val Met Glu Leu  Met Ala His Gly Asp  Leu Lys Ser 
    1100                 1105                 1110             


Tyr Leu  Arg Ser Leu Arg Pro  Glu Ala Glu Asn Asn  Pro Gly Arg 
    1115                 1120                 1125             


Pro Pro  Pro Thr Leu Gln Glu  Met Ile Gln Met Ala  Ala Glu Ile 
    1130                 1135                 1140             


Ala Asp  Gly Met Ala Tyr Leu  Asn Ala Lys Lys Phe  Val His Arg 
    1145                 1150                 1155             


Asp Leu  Ala Ala Arg Asn Cys  Met Val Ala His Asp  Phe Thr Val 
    1160                 1165                 1170             


Lys Ile  Gly Asp Phe Gly Met  Thr Arg Asp Ile Tyr  Glu Thr Asp 
    1175                 1180                 1185             


Tyr Tyr  Arg Lys Gly Gly Lys  Gly Leu Leu Pro Val  Arg Trp Met 
    1190                 1195                 1200             


Ala Pro  Glu Ser Leu Lys Asp  Gly Val Phe Thr Thr  Ser Ser Asp 
    1205                 1210                 1215             


Met Trp  Ser Phe Gly Val Val  Leu Trp Glu Ile Thr  Ser Leu Ala 
    1220                 1225                 1230             


Glu Gln  Pro Tyr Gln Gly Leu  Ser Asn Glu Gln Val  Leu Lys Phe 
    1235                 1240                 1245             


Val Met  Asp Gly Gly Tyr Leu  Asp Gln Pro Asp Asn  Cys Pro Glu 
    1250                 1255                 1260             


Arg Val  Thr Asp Leu Met Arg  Met Cys Trp Gln Phe  Asn Pro Lys 
    1265                 1270                 1275             


Met Arg  Pro Thr Phe Leu Glu  Ile Val Asn Leu Leu  Lys Asp Asp 
    1280                 1285                 1290             


Leu His  Pro Ser Phe Pro Glu  Val Ser Phe Phe His  Ser Glu Glu 
    1295                 1300                 1305             


Asn Lys  Ala Pro Glu Ser Glu  Glu Leu Glu Met Glu  Phe Glu Asp 
    1310                 1315                 1320             


Met Glu  Asn Val Pro Leu Asp  Arg Ser Ser His Cys  Gln Arg Glu 
    1325                 1330                 1335             


Glu Ala  Gly Gly Arg Asp Gly  Gly Ser Ser Leu Gly  Phe Lys Arg 
    1340                 1345                 1350             


Ser Tyr  Glu Glu His Ile Pro  Tyr Thr His Met Asn  Gly Gly Lys 
    1355                 1360                 1365             


Lys Asn  Gly Arg Ile Leu Thr  Leu Pro Arg Ser Asn  Pro Ser 
    1370                 1375                 1380         


<210>  3692
<211>  5386
<212>  DNA
<213>  Homosapiens

<400>  3692
tgaattcctg tcggagagcg aggacggtgc tggcaagaac gagaagagtg acaagagtac     60

cagtgtgaag cgcaggctga gctgcctccg cagtcgagtg accaggcaga aggagaaggg    120

gaagagccca gcacatctga aggacaaggg ccaggatgca cgagagaggc gggagtgtgt    180

caatgggcac cagctgttgc aagggacctt ctccggcccc tccagctgcc ccctgtgtgg    240

caaacctttc ttgagctcag cctcgctcaa ggagcacccc cggggcaccc tcctgtccga    300

tggcagcccg gccctgtcca ggaatgtcgg tatgacggtc tctcagaaag ggggtcccca    360

gccaacaccg agcccggctg gccctgggac gcaactcgga ccaatcacag gagagatgga    420

tgaagccgat tctgcgtttt taaaatttaa gcagacagct gatgactctc tgtcccttac    480

atctccaaac accgagtcca tttttgtaga agatccctac accgcctcgc tgaggagtga    540

gattgagtca gacggccacg agtttgaagc tgagtcctgg agcctcgccg tggatgcagc    600

ctacgccaag aagcaaaaga gggaggtggt gaaaagacaa gatgtccttt atgagctgat    660

gcagacagag gtgcaccacg tgcggacgct caagatcatg ctgaaggtgt actccagggc    720

cctgcaggag gagctgcagt tcagcagcaa ggccattggc cgcctcttcc catgcgctga    780

cgacctgctg gagacgcaca gccacttcct cgctcggctc aaggagcgcc gccaggagtc    840

cctggaggag ggcagtgacc ggaattatgt catccagaaa atcggcgacc tcctggttca    900

gcagttttca ggtgaaaatg gggagagaat gaaagaaaag tacggtgtgt tttgtagtgg    960

ccacaatgaa gctgttagtc attacaagtt gctgcttcag caaaacaaga aatttcaaaa   1020

cttgatcaag aaaattggca acttctccat cgtgcggcgg cttggcgtgc aggagtgcat   1080

tctcctggtt acacaacgca taaccaaata cccagtgctg gtggagcgca tcatccagaa   1140

cacggaagct ggcactgagg actatgaaga cctgacccag gccttgaacc tcatcaaaga   1200

tatcatctca caagtggacg ccaaggtcag tgagtgtgag aagggccagc gcctcaggga   1260

gatcgcaggg aagatggacc tgaagtcttc cagcaaactc aagaacgggc tcaccttccg   1320

caaggaagac atgcttcagc ggcagctcca cctggagggc atgctatgct ggaagaccac   1380

atcagggcgc ttgaaagata tcctggctat cctgctgacc gacgtacttt tgctgctaca   1440

agaaaaagat cagaaatacg tctttgcttc tgtggactca aagccacccg tcatctcgtt   1500

acaaaagctc atcgtgaggg aagtggccaa cgaggagaaa gcgatgtttc tgatcagcgc   1560

ctccttgcaa gggccggaga tgtatgaaat ctacacgagc tccaaagagg acaggaacgc   1620

ctggatggcc cacatccaaa gggctgtgga gagctgccct gacgaggagg aggggccctt   1680

cagcctgccc gaagaggaaa ggaaggtggt cgaggcccgc gccacgagac tccgggactt   1740

tcaagagcgg ttgagcatga aagaccagct gatcgcacag agcctcctag agaaacagca   1800

gatctacctg gagatggccg agatgggcgg cctcgaagac ctgccccagc cccgaggcct   1860

attccgtgga ggggacccat ccgagaccct gcagggggag ctaattctca agtcggccat   1920

gagcgagatc gagggcatcc agagcctgat ctgcaggcag ctgggcagcg ccaacggcca   1980

ggcggaagac ggaggcagct ccacaggccc gcccaggagg gctgagacct tcgcgggcta   2040

cgactgcaca aacagcccca ccaagaatgg cagtttcaag aagaaagtca gcagcactga   2100

ccccaggccc cgagactggc gaggcccccc aaacagcccg gacttgaagc tcagtgacag   2160

tgacattcct gggagctctg aggaatcgcc gcaggtggtg gaggcgccag gcacggaatc   2220

cgatccccgt ctgcccaccg tcctggagtc ggagcttgtc cagcggatcc agacactgtc   2280

ccagctgctc ctgaaccttc aggcggtaat cgcccaccag gacagctatg tggagacgca   2340

gcgggctgcc atccaggagc gggagaagca gttccggctg cagtcgacgc gtgggaacct   2400

gctgctggag caggagcggc aacgcaactt cgagaagcag cgggaggagc gcgcggccct   2460

ggagaagctg cagagccagc tgcggcacga gcagcagcgc tgggagcgcg agcgccagtg   2520

gcagcaccag gagctggagc gtgcgggcgc gcggctgcag gagcgcgagg gcgaggcgcg   2580

gcagctacgc gagcggctgg agcaggagcg ggccgagctg gagcgccagc gccaggccta   2640

ccagcacgac ctggagcggc tgcgcgaggc ccagcgtgcc gtggagcgcg agcgggagcg   2700

cctggagctg ctgcgccgcc tcaagaagca gaacaccgcg ccaggcgcgc tgccgcccga   2760

cacactggcc gaggcccagc ccccaagcca ccctcccagc ttcaacgggg aagggctgga   2820

gggccctcgt gtgagcatgc tgccatccgg cgtggggcca gagtacgcag agcgccccga   2880

ggtggctcgc cgggacagcg cccccaccga gaaccggctg gccaagagcg atgtgcccat   2940

ccagctgctc agcgccacca accagttcca gaggcaggcg gccgtgcagc agcagatccc   3000

caccaagctg gcggcctcca ccaagggtgg caaggacaag ggcggcaaga gcaggggctc   3060

tcagcgctgg gagagctcag cgtccttcga cctgaagcag cagctgctgc tcaacaagct   3120

catggggaaa gatgagagca cctcacggaa ccgccgctcg ctgagcccta tcctgcccgg   3180

cagacacagt cctgcgcccc caccagaccc tggcttcccc gccccgagcc caccgccagc   3240

tgacagcccc tccgagggct tctctctcaa ggccgggggc acagccctcc tgcccgggcc   3300

cccagctccc tcgccactgc cggccacacc actcagcgcc aaggaggacg ccagcaaaga   3360

agacgtcatc ttcttctaaa agggccgtga ctcaaggaaa gtttttaatg gaaagttgag   3420

ccagaactaa accagggagc tgtctgaaat catagcaccc catccgggtg gcggggagat   3480

caactccgag ctgtttttcc gaggcagtga ggaacggtgc cggctctgca cggagctgag   3540

gacaggacag accttgcttt gagaaggagc tgccggccgg ggccacgctc cacagccgcc   3600

gcgcgacagt ggagccaagg gttagggcac caggaggggc caggtggcgt cggcagcatc   3660

tgtccccaga atcaggcaga atccacttcc caaacagagc cccacgcagg ttcaccatga   3720

acctcagggt cagggaatga gccaggcacg ggggcatggg cagagagggc cacggggcag   3780

ggcccactga gggaacatca gtggccctcc agtcaggttc tgtgggtttg gaagcccatc   3840

gtgaaagggg ctgacctttg ccccttttta cttggcattg gttttgaaac cagctgtttc   3900

ccaaactctg cttcccaagg gcaaccgttg ctgttcacac gctcagcctg tctgggggag   3960

cgggcctcta gcttcagcca gggcgggtac acaccctggg cacagggtcc tcagcccccg   4020

ggaaatgagc tcccagggct ggcgtcccac cttccaggtg ggggctggca catcacagac   4080

tgtcgagagc gccatgtccc agggcatgca gaggatgcac ctagagacgt tgcagcaagt   4140

ggacaagtgg ccgctgtgcg ggcccctcgc ttgtagtgag ctgttgcagc ttacggtccg   4200

ttccctggag gggtggagga aggaggtgtt gggcagcatc aaaggtgctg ggacatccca   4260

gggtggtgag atccatccac gatccagctc cggtggagaa agggcccatg tcaagccttg   4320

ttctgcaccc caagcattgg tggtaggact gggtcctggc tgatcgtcct tgttcccagt   4380

ggggtacatg tgagcccctg ccagggccaa gtccttctcc cgaacccagg gtcctgggaa   4440

ctgcagatcc cggggggatt cagcccttct cccactgtgc tggcagaggc actcctgtga   4500

cgctgaatac agtgaacagg gacattcccg ccactcgggg acagatgggc acaagggagg   4560

ggaaactcca tcaggaagtg ctcccctggg cagaggcgcc cactgggtgc tgtgggctca   4620

ggagggggcg gggcaggagc tggtgccaac cgggaaccag agccccacag ccatacagcc   4680

cattggtgac aaggtcctga gaacacagtg gccaggtgtc cccaggctcc tggcccctcc   4740

gacgacctca actctgccca gcccggtccc tggccatcag cgacgctgtc cgccccccgt   4800

cagatcccat gtgtgccatg tttatcatca gtgttttgta tttttgtact gagtatcgga   4860

gcactttaca gaagctgact gtacattcct gttctgttgt gaagagaaca ttcccagacc   4920

ctggcaccct cctgagccgg cgtgtgccgg tccagccctc cgagatgcca caattccttg   4980

gatgggggag aagttcaagg aatttctgct cggccacgcg gtgggaaccc cgcgtccccg   5040

ccatgtggca gaggggtctc agtcgtgcta ggcatcgggc ggcagcgccg acagcccttc   5100

cctcgccagt gcccctcggc cactcctggg ttggagcccg attttatttg taaagttgac   5160

agtcgagcaa atgttcctat tttcgtggga tctgcacacg tctttgtcag ttgtggtcat   5220

gatcttagtc acctgctaat tatttttaca atgattacaa catttcctca ctgcgggata   5280

tttctgaccc gctttagaac ttaagacctg attctagcaa taaacgtgtc cgagatgagc   5340

ggtgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                  5386


<210>  3693
<211>  1015
<212>  PRT
<213>  Homosapiens

<400>  3693

Met Thr Val Ser Gln Lys Gly Gly Pro Gln Pro Thr Pro Ser Pro Ala 
1               5                   10                  15      


Gly Pro Gly Thr Gln Leu Gly Pro Ile Thr Gly Glu Met Asp Glu Ala 
            20                  25                  30          


Asp Ser Ala Phe Leu Lys Phe Lys Gln Thr Ala Asp Asp Ser Leu Ser 
        35                  40                  45              


Leu Thr Ser Pro Asn Thr Glu Ser Ile Phe Val Glu Asp Pro Tyr Thr 
    50                  55                  60                  


Ala Ser Leu Arg Ser Glu Ile Glu Ser Asp Gly His Glu Phe Glu Ala 
65                  70                  75                  80  


Glu Ser Trp Ser Leu Ala Val Asp Ala Ala Tyr Ala Lys Lys Gln Lys 
                85                  90                  95      


Arg Glu Val Val Lys Arg Gln Asp Val Leu Tyr Glu Leu Met Gln Thr 
            100                 105                 110         


Glu Val His His Val Arg Thr Leu Lys Ile Met Leu Lys Val Tyr Ser 
        115                 120                 125             


Arg Ala Leu Gln Glu Glu Leu Gln Phe Ser Ser Lys Ala Ile Gly Arg 
    130                 135                 140                 


Leu Phe Pro Cys Ala Asp Asp Leu Leu Glu Thr His Ser His Phe Leu 
145                 150                 155                 160 


Ala Arg Leu Lys Glu Arg Arg Gln Glu Ser Leu Glu Glu Gly Ser Asp 
                165                 170                 175     


Arg Asn Tyr Val Ile Gln Lys Ile Gly Asp Leu Leu Val Gln Gln Phe 
            180                 185                 190         


Ser Gly Glu Asn Gly Glu Arg Met Lys Glu Lys Tyr Gly Val Phe Cys 
        195                 200                 205             


Ser Gly His Asn Glu Ala Val Ser His Tyr Lys Leu Leu Leu Gln Gln 
    210                 215                 220                 


Asn Lys Lys Phe Gln Asn Leu Ile Lys Lys Ile Gly Asn Phe Ser Ile 
225                 230                 235                 240 


Val Arg Arg Leu Gly Val Gln Glu Cys Ile Leu Leu Val Thr Gln Arg 
                245                 250                 255     


Ile Thr Lys Tyr Pro Val Leu Val Glu Arg Ile Ile Gln Asn Thr Glu 
            260                 265                 270         


Ala Gly Thr Glu Asp Tyr Glu Asp Leu Thr Gln Ala Leu Asn Leu Ile 
        275                 280                 285             


Lys Asp Ile Ile Ser Gln Val Asp Ala Lys Val Ser Glu Cys Glu Lys 
    290                 295                 300                 


Gly Gln Arg Leu Arg Glu Ile Ala Gly Lys Met Asp Leu Lys Ser Ser 
305                 310                 315                 320 


Ser Lys Leu Lys Asn Gly Leu Thr Phe Arg Lys Glu Asp Met Leu Gln 
                325                 330                 335     


Arg Gln Leu His Leu Glu Gly Met Leu Cys Trp Lys Thr Thr Ser Gly 
            340                 345                 350         


Arg Leu Lys Asp Ile Leu Ala Ile Leu Leu Thr Asp Val Leu Leu Leu 
        355                 360                 365             


Leu Gln Glu Lys Asp Gln Lys Tyr Val Phe Ala Ser Val Asp Ser Lys 
    370                 375                 380                 


Pro Pro Val Ile Ser Leu Gln Lys Leu Ile Val Arg Glu Val Ala Asn 
385                 390                 395                 400 


Glu Glu Lys Ala Met Phe Leu Ile Ser Ala Ser Leu Gln Gly Pro Glu 
                405                 410                 415     


Met Tyr Glu Ile Tyr Thr Ser Ser Lys Glu Asp Arg Asn Ala Trp Met 
            420                 425                 430         


Ala His Ile Gln Arg Ala Val Glu Ser Cys Pro Asp Glu Glu Glu Gly 
        435                 440                 445             


Pro Phe Ser Leu Pro Glu Glu Glu Arg Lys Val Val Glu Ala Arg Ala 
    450                 455                 460                 


Thr Arg Leu Arg Asp Phe Gln Glu Arg Leu Ser Met Lys Asp Gln Leu 
465                 470                 475                 480 


Ile Ala Gln Ser Leu Leu Glu Lys Gln Gln Ile Tyr Leu Glu Met Ala 
                485                 490                 495     


Glu Met Gly Gly Leu Glu Asp Leu Pro Gln Pro Arg Gly Leu Phe Arg 
            500                 505                 510         


Gly Gly Asp Pro Ser Glu Thr Leu Gln Gly Glu Leu Ile Leu Lys Ser 
        515                 520                 525             


Ala Met Ser Glu Ile Glu Gly Ile Gln Ser Leu Ile Cys Arg Gln Leu 
    530                 535                 540                 


Gly Ser Ala Asn Gly Gln Ala Glu Asp Gly Gly Ser Ser Thr Gly Pro 
545                 550                 555                 560 


Pro Arg Arg Ala Glu Thr Phe Ala Gly Tyr Asp Cys Thr Asn Ser Pro 
                565                 570                 575     


Thr Lys Asn Gly Ser Phe Lys Lys Lys Val Ser Ser Thr Asp Pro Arg 
            580                 585                 590         


Pro Arg Asp Trp Arg Gly Pro Pro Asn Ser Pro Asp Leu Lys Leu Ser 
        595                 600                 605             


Asp Ser Asp Ile Pro Gly Ser Ser Glu Glu Ser Pro Gln Val Val Glu 
    610                 615                 620                 


Ala Pro Gly Thr Glu Ser Asp Pro Arg Leu Pro Thr Val Leu Glu Ser 
625                 630                 635                 640 


Glu Leu Val Gln Arg Ile Gln Thr Leu Ser Gln Leu Leu Leu Asn Leu 
                645                 650                 655     


Gln Ala Val Ile Ala His Gln Asp Ser Tyr Val Glu Thr Gln Arg Ala 
            660                 665                 670         


Ala Ile Gln Glu Arg Glu Lys Gln Phe Arg Leu Gln Ser Thr Arg Gly 
        675                 680                 685             


Asn Leu Leu Leu Glu Gln Glu Arg Gln Arg Asn Phe Glu Lys Gln Arg 
    690                 695                 700                 


Glu Glu Arg Ala Ala Leu Glu Lys Leu Gln Ser Gln Leu Arg His Glu 
705                 710                 715                 720 


Gln Gln Arg Trp Glu Arg Glu Arg Gln Trp Gln His Gln Glu Leu Glu 
                725                 730                 735     


Arg Ala Gly Ala Arg Leu Gln Glu Arg Glu Gly Glu Ala Arg Gln Leu 
            740                 745                 750         


Arg Glu Arg Leu Glu Gln Glu Arg Ala Glu Leu Glu Arg Gln Arg Gln 
        755                 760                 765             


Ala Tyr Gln His Asp Leu Glu Arg Leu Arg Glu Ala Gln Arg Ala Val 
    770                 775                 780                 


Glu Arg Glu Arg Glu Arg Leu Glu Leu Leu Arg Arg Leu Lys Lys Gln 
785                 790                 795                 800 


Asn Thr Ala Pro Gly Ala Leu Pro Pro Asp Thr Leu Ala Glu Ala Gln 
                805                 810                 815     


Pro Pro Ser His Pro Pro Ser Phe Asn Gly Glu Gly Leu Glu Gly Pro 
            820                 825                 830         


Arg Val Ser Met Leu Pro Ser Gly Val Gly Pro Glu Tyr Ala Glu Arg 
        835                 840                 845             


Pro Glu Val Ala Arg Arg Asp Ser Ala Pro Thr Glu Asn Arg Leu Ala 
    850                 855                 860                 


Lys Ser Asp Val Pro Ile Gln Leu Leu Ser Ala Thr Asn Gln Phe Gln 
865                 870                 875                 880 


Arg Gln Ala Ala Val Gln Gln Gln Ile Pro Thr Lys Leu Ala Ala Ser 
                885                 890                 895     


Thr Lys Gly Gly Lys Asp Lys Gly Gly Lys Ser Arg Gly Ser Gln Arg 
            900                 905                 910         


Trp Glu Ser Ser Ala Ser Phe Asp Leu Lys Gln Gln Leu Leu Leu Asn 
        915                 920                 925             


Lys Leu Met Gly Lys Asp Glu Ser Thr Ser Arg Asn Arg Arg Ser Leu 
    930                 935                 940                 


Ser Pro Ile Leu Pro Gly Arg His Ser Pro Ala Pro Pro Pro Asp Pro 
945                 950                 955                 960 


Gly Phe Pro Ala Pro Ser Pro Pro Pro Ala Asp Ser Pro Ser Glu Gly 
                965                 970                 975     


Phe Ser Leu Lys Ala Gly Gly Thr Ala Leu Leu Pro Gly Pro Pro Ala 
            980                 985                 990         


Pro Ser Pro Leu Pro Ala Thr Pro  Leu Ser Ala Lys Glu  Asp Ala Ser 
        995                 1000                 1005             


Lys Glu  Asp Val Ile Phe Phe  
    1010                 1015 


<210>  3694
<211>  1143
<212>  DNA
<213>  Homosapiens

<400>  3694
ggagttgcca tggcgtcgct gagcggcctg gcgtcggcgc tggagtcgta caggggccgg     60

gaccgcctga tccgagtgct ggggtactgc tgccagctgg ttggtggagt tctggttgaa    120

cagtgtcccg ccaggtccga agtggggaca cgtctgttgg tggtgtccac ccaactcagc    180

cactgcagga ccatcttgcg actctttgat gacctggcca tgtttgtcta cactaagcaa    240

tatggcctgg gggcacagga ggaggacgcc tttgtccgct gtgtctccgt cctagggaac    300

ctggctgacc agctctacta cccctgtgag cacgtggcct gggcggctga tgcccgggtc    360

ctccacgtgg actcttctcg gtggtggacg ctgagtacaa ccctgtgggc cctctctctg    420

ctcctggggg ttgccaggtc cctgtggatg ctgctgaaac tgagacagag gctgcggagc    480

cccacggcgc ccttcaccag cccgctgccc cggggcaagc ggagggccat ggaggcgcag    540

atgcagtcgg aggcgctgtc acttctcagc aacctggccg acctggccaa cgccgtgcac    600

tggctgcccc ggggcgtgct gtgggccggc cgcttcccgc cgtggctagt gggcctcatg    660

ggcaccatct cctcaatcct cagcatgtac caggcggccc gggccggcgg ccaggccgag    720

gccactaccc cctgacactg ccggaagagc acagggacac agccagagcc cacggagggc    780

ccttcccgca aagcagaagc cgccagggca ggggccgggg ctctcatgga gctgcctgtg    840

gtgaaaccca tgggcagggt gggtggaggg actgatgcga ggtcccccag gcctcagcct    900

ggagctcctg agccgtgaca gttttcaggg gccgtgcagg gcttcagcag cacctcctgc    960

ctgccagctg gcgtcttgta tccaaatcaa gatgaggaag agggggcctg tcgtgccttg   1020

agaaagctgg aacgggaatc aattaaacat tgtggtgctg gcaaaaaaaa aaaaaaaaaa   1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1140

aaa                                                                 1143


<210>  3695
<211>  241
<212>  PRT
<213>  Homosapiens

<400>  3695

Met Ala Ser Leu Ser Gly Leu Ala Ser Ala Leu Glu Ser Tyr Arg Gly 
1               5                   10                  15      


Arg Asp Arg Leu Ile Arg Val Leu Gly Tyr Cys Cys Gln Leu Val Gly 
            20                  25                  30          


Gly Val Leu Val Glu Gln Cys Pro Ala Arg Ser Glu Val Gly Thr Arg 
        35                  40                  45              


Leu Leu Val Val Ser Thr Gln Leu Ser His Cys Arg Thr Ile Leu Arg 
    50                  55                  60                  


Leu Phe Asp Asp Leu Ala Met Phe Val Tyr Thr Lys Gln Tyr Gly Leu 
65                  70                  75                  80  


Gly Ala Gln Glu Glu Asp Ala Phe Val Arg Cys Val Ser Val Leu Gly 
                85                  90                  95      


Asn Leu Ala Asp Gln Leu Tyr Tyr Pro Cys Glu His Val Ala Trp Ala 
            100                 105                 110         


Ala Asp Ala Arg Val Leu His Val Asp Ser Ser Arg Trp Trp Thr Leu 
        115                 120                 125             


Ser Thr Thr Leu Trp Ala Leu Ser Leu Leu Leu Gly Val Ala Arg Ser 
    130                 135                 140                 


Leu Trp Met Leu Leu Lys Leu Arg Gln Arg Leu Arg Ser Pro Thr Ala 
145                 150                 155                 160 


Pro Phe Thr Ser Pro Leu Pro Arg Gly Lys Arg Arg Ala Met Glu Ala 
                165                 170                 175     


Gln Met Gln Ser Glu Ala Leu Ser Leu Leu Ser Asn Leu Ala Asp Leu 
            180                 185                 190         


Ala Asn Ala Val His Trp Leu Pro Arg Gly Val Leu Trp Ala Gly Arg 
        195                 200                 205             


Phe Pro Pro Trp Leu Val Gly Leu Met Gly Thr Ile Ser Ser Ile Leu 
    210                 215                 220                 


Ser Met Tyr Gln Ala Ala Arg Ala Gly Gly Gln Ala Glu Ala Thr Thr 
225                 230                 235                 240 


Pro 
    


<210>  3696
<211>  1669
<212>  DNA
<213>  Homosapiens

<400>  3696
ccagggacag agggagaccc aaagatctgg tctgtagcta agtgaatttt ctaaaactca     60

ttgattcaca cgccatccct tgaggtggct ggtgtcccgc gatggccaca ggcgccctcc    120

tgccgtgctc gcgcccgtgc ccgatgtccc ggctggactt cctcaaggcc tcgcacttct    180

cgctggggcc tgacctgcgg ctgcacgagg gcaccatgcg caccacgtcg caccgggact    240

ttgcctaccc ggctgccacc cgggagccgc cgagcctgca gccgccgccc gcgctgcttt    300

tcccaatgga cccgcgctgg gaccgggaag agcgcgtgtc ggaggcgcac cgcgcgttcc    360

cgccgccatc cacgccgccg tgggagctgc tgcaagcgca ggcgcgggaa cgcacgctcg    420

ccatgcaggc cggcaacctg cacctgcacg aggacgcgca cgccgggatc ggcctctcca    480

acgcgcacgc cgcctacggc tggcccgagc tgccggcgcg cacccgagag cggatccgcg    540

gcgcgcgcct catcttcgac cgcgactccc tgcctcctgg cgaccgcgac aagttgcgca    600

tcccgcccac cacgcaccag gcgctctttc caccccacga cgcgcgcccg cagcctcgcg    660

cgcccagttg ccacctcggg ggccccaaca ccctcaagtg ggactacacg agacaagatg    720

ggacttccta ccaaagacag ttccaggccc tgccaggccc acctgccttg aggtgtaaga    780

gggcctcctc cggagtggag ctgggagact gcaagatcag ctatggatca acgtgttcgg    840

agcagaaaca ggcctacagg ccccaggatc tgcctgaaga taggtatgac aaggcccagg    900

ccacagccca catccactgt gtaaatatcc gtcctggtga cggcctcttc cgcgacagga    960

ccaccaaggc cgagcacttc tatgccaggg agccagagcc ttttgttctt caccacgatc   1020

agactccgga gtcgcacatc ctgaaaggaa attggtgccc cggccccggc agtctggaca   1080

ccttcatgca gtacttctac ggccagccgc cacccccgac ccagccaccc agccgccacg   1140

tgcctcatga gaaattgcag agtcatgtga ccctagggga gccaaagcta ctcaaacgct   1200

tcttcaagac caccatgggc tcggactact gcccttcaga gtggagacag gtgcagaaag   1260

cgcccaacct ccacttgcag caaagctacc tgccgcgggg cacgggcgaa ttcgattttt   1320

taaccatgaa ccagaagatg ctgaagccac acagaacacc tccggccccg gtgactgaag   1380

agatgctaca gcggtgcaag tacagccaca tggagccccc tctgggtgga ctgcgcttct   1440

tctcaacaca atacaaggac gagtttcctt tcaagtacca gggcccagca gccctgagac   1500

tgaaaaatcc tcaggagggc ttcgtgcccc tgggcacgcc tcaccagcgc ggctgcaggg   1560

agaagataga ccctctggtc ccccagcccc ctatgtacct gtgccccagc cagcaataaa   1620

tgccatcttg gcaacattca aaaaaaaaaa aaaaaaaaaa aaaaaaaaa               1669


<210>  3697
<211>  491
<212>  PRT
<213>  Homosapiens

<400>  3697

Met Ser Arg Leu Asp Phe Leu Lys Ala Ser His Phe Ser Leu Gly Pro 
1               5                   10                  15      


Asp Leu Arg Leu His Glu Gly Thr Met Arg Thr Thr Ser His Arg Asp 
            20                  25                  30          


Phe Ala Tyr Pro Ala Ala Thr Arg Glu Pro Pro Ser Leu Gln Pro Pro 
        35                  40                  45              


Pro Ala Leu Leu Phe Pro Met Asp Pro Arg Trp Asp Arg Glu Glu Arg 
    50                  55                  60                  


Val Ser Glu Ala His Arg Ala Phe Pro Pro Pro Ser Thr Pro Pro Trp 
65                  70                  75                  80  


Glu Leu Leu Gln Ala Gln Ala Arg Glu Arg Thr Leu Ala Met Gln Ala 
                85                  90                  95      


Gly Asn Leu His Leu His Glu Asp Ala His Ala Gly Ile Gly Leu Ser 
            100                 105                 110         


Asn Ala His Ala Ala Tyr Gly Trp Pro Glu Leu Pro Ala Arg Thr Arg 
        115                 120                 125             


Glu Arg Ile Arg Gly Ala Arg Leu Ile Phe Asp Arg Asp Ser Leu Pro 
    130                 135                 140                 


Pro Gly Asp Arg Asp Lys Leu Arg Ile Pro Pro Thr Thr His Gln Ala 
145                 150                 155                 160 


Leu Phe Pro Pro His Asp Ala Arg Pro Gln Pro Arg Ala Pro Ser Cys 
                165                 170                 175     


His Leu Gly Gly Pro Asn Thr Leu Lys Trp Asp Tyr Thr Arg Gln Asp 
            180                 185                 190         


Gly Thr Ser Tyr Gln Arg Gln Phe Gln Ala Leu Pro Gly Pro Pro Ala 
        195                 200                 205             


Leu Arg Cys Lys Arg Ala Ser Ser Gly Val Glu Leu Gly Asp Cys Lys 
    210                 215                 220                 


Ile Ser Tyr Gly Ser Thr Cys Ser Glu Gln Lys Gln Ala Tyr Arg Pro 
225                 230                 235                 240 


Gln Asp Leu Pro Glu Asp Arg Tyr Asp Lys Ala Gln Ala Thr Ala His 
                245                 250                 255     


Ile His Cys Val Asn Ile Arg Pro Gly Asp Gly Leu Phe Arg Asp Arg 
            260                 265                 270         


Thr Thr Lys Ala Glu His Phe Tyr Ala Arg Glu Pro Glu Pro Phe Val 
        275                 280                 285             


Leu His His Asp Gln Thr Pro Glu Ser His Ile Leu Lys Gly Asn Trp 
    290                 295                 300                 


Cys Pro Gly Pro Gly Ser Leu Asp Thr Phe Met Gln Tyr Phe Tyr Gly 
305                 310                 315                 320 


Gln Pro Pro Pro Pro Thr Gln Pro Pro Ser Arg His Val Pro His Glu 
                325                 330                 335     


Lys Leu Gln Ser His Val Thr Leu Gly Glu Pro Lys Leu Leu Lys Arg 
            340                 345                 350         


Phe Phe Lys Thr Thr Met Gly Ser Asp Tyr Cys Pro Ser Glu Trp Arg 
        355                 360                 365             


Gln Val Gln Lys Ala Pro Asn Leu His Leu Gln Gln Ser Tyr Leu Pro 
    370                 375                 380                 


Arg Gly Thr Gly Glu Phe Asp Phe Leu Thr Met Asn Gln Lys Met Leu 
385                 390                 395                 400 


Lys Pro His Arg Thr Pro Pro Ala Pro Val Thr Glu Glu Met Leu Gln 
                405                 410                 415     


Arg Cys Lys Tyr Ser His Met Glu Pro Pro Leu Gly Gly Leu Arg Phe 
            420                 425                 430         


Phe Ser Thr Gln Tyr Lys Asp Glu Phe Pro Phe Lys Tyr Gln Gly Pro 
        435                 440                 445             


Ala Ala Leu Arg Leu Lys Asn Pro Gln Glu Gly Phe Val Pro Leu Gly 
    450                 455                 460                 


Thr Pro His Gln Arg Gly Cys Arg Glu Lys Ile Asp Pro Leu Val Pro 
465                 470                 475                 480 


Gln Pro Pro Met Tyr Leu Cys Pro Ser Gln Gln 
                485                 490     


<210>  3698
<211>  1897
<212>  DNA
<213>  Homosapiens

<400>  3698
cccgggggga gccggcggcc ggcgcgggcg cggcgggccg ggcaggggcg aggggcgccg     60

ggtcttgccc cagaagctgc gggcacatcc acgcctgaaa tgcggcgctc agtcctggtc    120

aggaacccag gccacaaagg cctgagaccc gtttatgaag agctcgactc tgactccgag    180

gacctagacc ccaatcctga agatctggac ccggtttctg aagacccaga gcctgatcct    240

gaagacctca acactgtccc ggaagacgtg gaccccagct atgaagatct ggagcccgtc    300

tcggaggatc tggaccccga cgccgaagct ccgggctcgg aaccccaaga tcccgacccc    360

atgtcttcga gtttcgacct cgatccagat gtgattggcc ccgtacccct gattctcgat    420

cctaacagcg acaccctcag ccccggcgat ccaaaagtgg accccatctc ctctggcctc    480

actgccaccc cccaggtctt ggccaccagc cccgcggtgc tccccgcccc cgccagcccg    540

ccccggccct tctcctgccc ggattgcggg cgagccttcc gccgcagctc cgggctgagc    600

cagcatcgcc gcacgcacag cggcgagaag ccgtaccgct gccccgactg cgggaagtcc    660

ttcagccacg gtgccaccct ggctcagcac cgtggcatcc acactggggc gcggccgtac    720

cagtgcgcgg cctgcggcaa ggccttcggc tggcgctcca cgctgctgaa acatcgcagc    780

agccacagcg gggagaagcc gcaccactgc ccggtgtgtg gcaaggcctt cgggcacggc    840

tcgctcctgg cacagcacct gcgcacgcac ggcggcccgc ggccccacaa gtgcccggtg    900

tgcgccaagg gcttcggcca gggctctgcg ctgctcaaac acctgcgcac gcacacgggc    960

gagcggccct acccgtgtcc gcagtgcggc aaggccttcg ggcagagctc ggcgctgctg   1020

cagcaccagc gcacacacac ggccgagcgc ccctaccgct gcccccactg cggcaaagcc   1080

ttcgggcaga gctccaactt gcaacaccac ctgcgcatcc acacgggcga gcggccctac   1140

gcctgcccgc actgctccaa ggccttcggc cagagctcag cgctgctcca gcacctgcac   1200

gtgcattcgg gcgagcgtcc ctatcgctgt cagctctgcg ggaaggcctt cggccaggcc   1260

tccagcctca ccaagcacaa acgggtgcat gagggtgcag ccgctgctgc agctgccgcg   1320

gccgctgcag ctgcagcagc ggccgccggc ctgggcctcg ggcctggcct aagccctgca   1380

tccatgatga ggccggggca ggtctccctc ctgggtcctg atgctgtttc tgtgctcggc   1440

tctggcttgg gcctcagccc tggcaccagc tctggccgca accctgaccc tggctctggg   1500

ccgggcactc tgccggatcc cagctccaaa cccctccccg gctccagatc cacccccagc   1560

cctactcctg tggaatcttc tgacccaaag gctgggcacg acgctggtcc cgaccttgtg   1620

cccagcccag accttgatcc tgtgcccagc ccagaccctg atcctgtgcc cagccctgat   1680

cccaaccctg tgtcctgccc tgacccctgt tctcccactc gtggcactgt cagcccagcc   1740

ctccctaccg gcgagagtcc agagtgggta caggagcaag gggcactgct ggggcctgat   1800

ggctgaagga gacgccggca tcctcggggg cctggggaag ttgtgtgttg tgcagtcagt   1860

aaaatcctcc cactgcctcc ggaaaaaaaa aaaaaaa                            1897


<210>  3699
<211>  481
<212>  PRT
<213>  Homosapiens

<400>  3699

Met Ser Ser Ser Phe Asp Leu Asp Pro Asp Val Ile Gly Pro Val Pro 
1               5                   10                  15      


Leu Ile Leu Asp Pro Asn Ser Asp Thr Leu Ser Pro Gly Asp Pro Lys 
            20                  25                  30          


Val Asp Pro Ile Ser Ser Gly Leu Thr Ala Thr Pro Gln Val Leu Ala 
        35                  40                  45              


Thr Ser Pro Ala Val Leu Pro Ala Pro Ala Ser Pro Pro Arg Pro Phe 
    50                  55                  60                  


Ser Cys Pro Asp Cys Gly Arg Ala Phe Arg Arg Ser Ser Gly Leu Ser 
65                  70                  75                  80  


Gln His Arg Arg Thr His Ser Gly Glu Lys Pro Tyr Arg Cys Pro Asp 
                85                  90                  95      


Cys Gly Lys Ser Phe Ser His Gly Ala Thr Leu Ala Gln His Arg Gly 
            100                 105                 110         


Ile His Thr Gly Ala Arg Pro Tyr Gln Cys Ala Ala Cys Gly Lys Ala 
        115                 120                 125             


Phe Gly Trp Arg Ser Thr Leu Leu Lys His Arg Ser Ser His Ser Gly 
    130                 135                 140                 


Glu Lys Pro His His Cys Pro Val Cys Gly Lys Ala Phe Gly His Gly 
145                 150                 155                 160 


Ser Leu Leu Ala Gln His Leu Arg Thr His Gly Gly Pro Arg Pro His 
                165                 170                 175     


Lys Cys Pro Val Cys Ala Lys Gly Phe Gly Gln Gly Ser Ala Leu Leu 
            180                 185                 190         


Lys His Leu Arg Thr His Thr Gly Glu Arg Pro Tyr Pro Cys Pro Gln 
        195                 200                 205             


Cys Gly Lys Ala Phe Gly Gln Ser Ser Ala Leu Leu Gln His Gln Arg 
    210                 215                 220                 


Thr His Thr Ala Glu Arg Pro Tyr Arg Cys Pro His Cys Gly Lys Ala 
225                 230                 235                 240 


Phe Gly Gln Ser Ser Asn Leu Gln His His Leu Arg Ile His Thr Gly 
                245                 250                 255     


Glu Arg Pro Tyr Ala Cys Pro His Cys Ser Lys Ala Phe Gly Gln Ser 
            260                 265                 270         


Ser Ala Leu Leu Gln His Leu His Val His Ser Gly Glu Arg Pro Tyr 
        275                 280                 285             


Arg Cys Gln Leu Cys Gly Lys Ala Phe Gly Gln Ala Ser Ser Leu Thr 
    290                 295                 300                 


Lys His Lys Arg Val His Glu Gly Ala Ala Ala Ala Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Leu Gly Leu Gly Pro Gly 
                325                 330                 335     


Leu Ser Pro Ala Ser Met Met Arg Pro Gly Gln Val Ser Leu Leu Gly 
            340                 345                 350         


Pro Asp Ala Val Ser Val Leu Gly Ser Gly Leu Gly Leu Ser Pro Gly 
        355                 360                 365             


Thr Ser Ser Gly Arg Asn Pro Asp Pro Gly Ser Gly Pro Gly Thr Leu 
    370                 375                 380                 


Pro Asp Pro Ser Ser Lys Pro Leu Pro Gly Ser Arg Ser Thr Pro Ser 
385                 390                 395                 400 


Pro Thr Pro Val Glu Ser Ser Asp Pro Lys Ala Gly His Asp Ala Gly 
                405                 410                 415     


Pro Asp Leu Val Pro Ser Pro Asp Leu Asp Pro Val Pro Ser Pro Asp 
            420                 425                 430         


Pro Asp Pro Val Pro Ser Pro Asp Pro Asn Pro Val Ser Cys Pro Asp 
        435                 440                 445             


Pro Cys Ser Pro Thr Arg Gly Thr Val Ser Pro Ala Leu Pro Thr Gly 
    450                 455                 460                 


Glu Ser Pro Glu Trp Val Gln Glu Gln Gly Ala Leu Leu Gly Pro Asp 
465                 470                 475                 480 


Gly 
    


<210>  3700
<211>  2051
<212>  DNA
<213>  Homosapiens

<400>  3700
agatcagctg atgccggagg gtttgaagcc gcgccgcgag ggagcgaggt cgcagtgaca     60

gcggcgggcg atcggaccca ggctgccccg ccgtacccgc ctgcgtcccg cgctcccgcc    120

ccagcatgac agccccggcg ggtccgcgcg gctcagagac cgagcggctt ctgaccccca    180

accccgggta tgggacccag gcggggcctt caccggcccc tccgacaccc ccagaagagg    240

aagaccttcg ccgtcgtctc aaatactttt tcatgagtcc ctgcgacaag tttcgagcca    300

agggccgcaa gccctgcaag ctgatgctgc aagtggtcaa gatcctggtg gtcacggtgc    360

agctcatcct gtttgggctc agtaatcagc tggctgtgac attccgggaa gagaacacca    420

tcgccttccg acacctcttc ctgctgggct actcggacgg agcggatgac accttcgcag    480

cctacacgcg ggagcagctg taccaggcca tcttccatgc tgtggaccag tacctggcgt    540

tgcctgacgt gtcactgggc cggtatgcgt atgtccgtgg tgggggtgac ccttggacca    600

atggctcagg gcttgctctc tgccagcggt actaccaccg aggccacgtg gacccggcca    660

acgacacatt tgacattgat ccgatggtgg ttactgactg catccaggtg gatccccccg    720

agcggccccc tccgcccccc agcgacgatc tcaccctctt ggaaagcagc tccagttaca    780

agaacctcac gctcaaattc cacaagctgg tcaatgtcac catccacttc cggctgaaga    840

ccattaacct ccagagcctc atcaataatg agatcccgga ctgctatacc ttcagcgtcc    900

tgatcacgtt tgacaacaaa gcacacagtg ggcggatccc catcagcctg gagacccagg    960

cccacatcca ggagtgtaag caccccagtg tcttccagca cggagacaac agcttccggc   1020

tcctgtttga cgtggtggtc atcctcacct gctccctgtc cttcctcctc tgcgcccgct   1080

cactccttcg aggcttcctg ctgcagaacg agtttgtggg gttcatgtgg cggcagcggg   1140

gacgggtcat cagcctgtgg gagcggctgg aatttgtcaa tggctggtac atcctgctcg   1200

tcaccagcga tgtgctcacc atctcgggca ccatcatgaa gatcggcatc gaggccaaga   1260

acttggcgag ctacgacgtc tgcagcatcc tcctgggcac ctcgacgctg ctggtgtggg   1320

tgggcgtgat ccgctacctg accttcttcc acaactacaa tatcctcatc gccacactgc   1380

gggtggccct gcccagcgtc atgcgcttct gctgctgcgt ggctgtcatc tacctgggct   1440

actgcttctg tggctggatc gtgctggggc cctatcatgt gaagttccgc tcactctcca   1500

tggtgtctga gtgcctgttc tcgctcatca atggggacga catgtttgtg acgttcgccg   1560

ccatgcaggc gcagcagggc cgcagcagcc tggtgtggct cttctcccag ctctaccttt   1620

actccttcat cagcctcttc atctacatgg tgctcagcct cttcatcgcg ctcatcaccg   1680

gcgcctacga caccatcaag catcccggcg gcgcaggcgc agaggagagc gagctgcagg   1740

cctacatcgc acagtgccag gacagcccca cctccggcaa gttccgccgc gggagcggct   1800

cggcctgcag ccttctctgc tgctgcggaa gggacccctc ggaggagcat tcgctgctgg   1860

tgaattgatt cgacctgact gccgttggac cgtaggccct ggactgcaga gacccccgcc   1920

cccgaccccg cttatttatt tgtagggttt gcttttaagg atcggctccc tgtcgcgccc   1980

gaggagggcc tggacctttc gtgtcggacc cttgggggcg gggagactgg gtggggaggg   2040

tgttgaataa a                                                        2051


<210>  3701
<211>  580
<212>  PRT
<213>  Homosapiens

<400>  3701

Met Thr Ala Pro Ala Gly Pro Arg Gly Ser Glu Thr Glu Arg Leu Leu 
1               5                   10                  15      


Thr Pro Asn Pro Gly Tyr Gly Thr Gln Ala Gly Pro Ser Pro Ala Pro 
            20                  25                  30          


Pro Thr Pro Pro Glu Glu Glu Asp Leu Arg Arg Arg Leu Lys Tyr Phe 
        35                  40                  45              


Phe Met Ser Pro Cys Asp Lys Phe Arg Ala Lys Gly Arg Lys Pro Cys 
    50                  55                  60                  


Lys Leu Met Leu Gln Val Val Lys Ile Leu Val Val Thr Val Gln Leu 
65                  70                  75                  80  


Ile Leu Phe Gly Leu Ser Asn Gln Leu Ala Val Thr Phe Arg Glu Glu 
                85                  90                  95      


Asn Thr Ile Ala Phe Arg His Leu Phe Leu Leu Gly Tyr Ser Asp Gly 
            100                 105                 110         


Ala Asp Asp Thr Phe Ala Ala Tyr Thr Arg Glu Gln Leu Tyr Gln Ala 
        115                 120                 125             


Ile Phe His Ala Val Asp Gln Tyr Leu Ala Leu Pro Asp Val Ser Leu 
    130                 135                 140                 


Gly Arg Tyr Ala Tyr Val Arg Gly Gly Gly Asp Pro Trp Thr Asn Gly 
145                 150                 155                 160 


Ser Gly Leu Ala Leu Cys Gln Arg Tyr Tyr His Arg Gly His Val Asp 
                165                 170                 175     


Pro Ala Asn Asp Thr Phe Asp Ile Asp Pro Met Val Val Thr Asp Cys 
            180                 185                 190         


Ile Gln Val Asp Pro Pro Glu Arg Pro Pro Pro Pro Pro Ser Asp Asp 
        195                 200                 205             


Leu Thr Leu Leu Glu Ser Ser Ser Ser Tyr Lys Asn Leu Thr Leu Lys 
    210                 215                 220                 


Phe His Lys Leu Val Asn Val Thr Ile His Phe Arg Leu Lys Thr Ile 
225                 230                 235                 240 


Asn Leu Gln Ser Leu Ile Asn Asn Glu Ile Pro Asp Cys Tyr Thr Phe 
                245                 250                 255     


Ser Val Leu Ile Thr Phe Asp Asn Lys Ala His Ser Gly Arg Ile Pro 
            260                 265                 270         


Ile Ser Leu Glu Thr Gln Ala His Ile Gln Glu Cys Lys His Pro Ser 
        275                 280                 285             


Val Phe Gln His Gly Asp Asn Ser Phe Arg Leu Leu Phe Asp Val Val 
    290                 295                 300                 


Val Ile Leu Thr Cys Ser Leu Ser Phe Leu Leu Cys Ala Arg Ser Leu 
305                 310                 315                 320 


Leu Arg Gly Phe Leu Leu Gln Asn Glu Phe Val Gly Phe Met Trp Arg 
                325                 330                 335     


Gln Arg Gly Arg Val Ile Ser Leu Trp Glu Arg Leu Glu Phe Val Asn 
            340                 345                 350         


Gly Trp Tyr Ile Leu Leu Val Thr Ser Asp Val Leu Thr Ile Ser Gly 
        355                 360                 365             


Thr Ile Met Lys Ile Gly Ile Glu Ala Lys Asn Leu Ala Ser Tyr Asp 
    370                 375                 380                 


Val Cys Ser Ile Leu Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly 
385                 390                 395                 400 


Val Ile Arg Tyr Leu Thr Phe Phe His Asn Tyr Asn Ile Leu Ile Ala 
                405                 410                 415     


Thr Leu Arg Val Ala Leu Pro Ser Val Met Arg Phe Cys Cys Cys Val 
            420                 425                 430         


Ala Val Ile Tyr Leu Gly Tyr Cys Phe Cys Gly Trp Ile Val Leu Gly 
        435                 440                 445             


Pro Tyr His Val Lys Phe Arg Ser Leu Ser Met Val Ser Glu Cys Leu 
    450                 455                 460                 


Phe Ser Leu Ile Asn Gly Asp Asp Met Phe Val Thr Phe Ala Ala Met 
465                 470                 475                 480 


Gln Ala Gln Gln Gly Arg Ser Ser Leu Val Trp Leu Phe Ser Gln Leu 
                485                 490                 495     


Tyr Leu Tyr Ser Phe Ile Ser Leu Phe Ile Tyr Met Val Leu Ser Leu 
            500                 505                 510         


Phe Ile Ala Leu Ile Thr Gly Ala Tyr Asp Thr Ile Lys His Pro Gly 
        515                 520                 525             


Gly Ala Gly Ala Glu Glu Ser Glu Leu Gln Ala Tyr Ile Ala Gln Cys 
    530                 535                 540                 


Gln Asp Ser Pro Thr Ser Gly Lys Phe Arg Arg Gly Ser Gly Ser Ala 
545                 550                 555                 560 


Cys Ser Leu Leu Cys Cys Cys Gly Arg Asp Pro Ser Glu Glu His Ser 
                565                 570                 575     


Leu Leu Val Asn 
            580 


<210>  3702
<211>  4471
<212>  DNA
<213>  Homosapiens

<400>  3702
gcggaacgct agcggtgttg gcgcggagtg gaccccggct gcggcccctg gcaatggcgc     60

caccatcggt cccggagtcc cagtgatgct ctgtgccata gagcccccat aacttcacta    120

ctacgtgata gtaaatcccc ggcaaaaacc agcagcgcct tgcaagccca cgccacccca    180

agcatcccag gactcttctg aaacgactcc gggctaccag atcggccgtc cagctggaat    240

caaccgatgg aggctccgct gcaaactgga atggtgcttg gcgtgatgat cggggccgga    300

gtggcggtgg tggtcacggc cgtgctcatc ctcctggtgg tgcggaggct gcgagtgcca    360

aaaaccccag ccccggatgg cccccggtat cggttccgga agagggacaa agtgctcttc    420

tatggccgga agattatgcg gaaggtgtca caatccacct cctccctcgt ggatacctct    480

gtctccgcca cctcccggcc acgcatgagg aagaaactga agatgctcaa cattgccaag    540

aagatcctgc gcatccagaa agagacgccc acgctgcagc ggaaggagcc cccgcccgca    600

gtgctagaag ctgacctgac cgagggcgac ctggctaact cccatctgcc ctctgaagtg    660

ctttatatgc tcaagaacgt ccgggtgctg ggccacttcg agaagccact cttcctggag    720

ctctgccgcc acatggtctt ccagcggctg ggccagggtg actacgtctt ccggccgggc    780

cagccagatg ccagcatcta cgtggtgcag gacgggctgc tggagctctg tctgccaggg    840

cctgacggga aggagtgtgt ggtgaaggaa gtggttcctg gggacagcgt caacagcctt    900

ctcagcatcc tggatgtcat caccggtcac cagcatcccc agcggaccgt gtctgcccgg    960

gcggcccggg actccacggt gctgcgcctg ccggtggaag cattctccgc ggtcttcacc   1020

aagtacccgg agagcttggt gcgggtcgtg cagatcatca tggtgcggct gcagcgagtc   1080

accttcctgg cactgcacaa ctacctgggt ctgaccaatg agctcttcag ccacgagatc   1140

cagcccctgc gtctgttccc cagccccggc ctcccaactc gcaccagccc tgtgcggggc   1200

tccaagagaa tggtcagcac ctcagctaca gacgagccca gggagacccc agggcggcca   1260

cccgatccca ccggggcccc gctgcctgga cctacagggg accctgtgaa gcccacatcc   1320

ctggaaaccc cctcgccccc tctgctgagc cgctgcgtct ccatgccagg ggacatctca   1380

ggcttgcagg gtggcccccg ctccgacttc gacatggcct atgagcgtgg ccggatctcc   1440

gtgtccctgc aagaagaggc ctccgggggg tccctggcag cccccgctcg gacccccact   1500

caggagcctc gtgagcagcc ggcaggcgcc tgtgaataca gctactgtga ggatgagtcg   1560

gccactggtg gctgcccttt cgggccctac cagggccgcc agaccagcag catcttcgag   1620

gcagcaaagc aggagctggc caagctgatg cggattgagg acccctccct cctgaacagc   1680

agagtcttgc tgcaccacgc caaagctggc accatcattg cccgccaggg agaccaggac   1740

gtgagcctgc acttcgtgct ctggggctgc ctgcacgtgt accagcgcat gatcgacaag   1800

gcggaggacg tgtgcctgtt cgtagcgcag cccggggaac tggtggggca gctggcggtg   1860

ctcactggcg aacctctcat cttcacactg cgagcccaac gcgactgcac cttcctgcgg   1920

atctccaagt ccgacttcta tgagatcatg cgcgcacagc ccagtgtggt gctgagtgcg   1980

gcgcacacgg tggcagccag gatgtcgccc ttcgtgcgcc agatggactt cgccatcgac   2040

tggactgcag tggaggcggg acgcgcgctg tacaggcagg gcgaccgctc cgactgcact   2100

tacatcgtgc tcaatgggcg gctgcgtagc gtgatccagc gaggcagtgg caagaaggag   2160

ctggtgggcg agtacggccg cggcgacctc atcggcgtgg tggaggcact gacccggcag   2220

ccgcgagcca cgacggtgca cgcggtgcgc gacacggagc tggccaagct tcccgagggc   2280

accttgggtc acatcaaacg ccggtacccg caggtcgtga cccgccttat ccacctactg   2340

agccagaaaa ttctagggaa tttgcagcag ctgcaaggac ccttcccagc aggctctggg   2400

ttgggtgtgc ccccacactc ggaactcacc aacccagcca gcaacctggc aactgtggca   2460

atcctgcctg tgtgtgctga ggtccccatg gtggccttca cgctggagct gcagcacgcc   2520

ctgcaggcca tcggtccgac gctactcctt aacagtgaca tcatccgggc acgcctgggg   2580

gcctccgcac tggatagcat ccaagagttc cggctgtcag ggtggctggc ccagcaggag   2640

gatgcacacc gtatcgtact ctaccagacg gacgcctcgc tgacgccctg gaccgtgcgc   2700

tgcctgcgac aggccgactg catcctcatt gtgggcctgg gggaccagga gcctaccctc   2760

ggccagctgg agcagatgct ggagaacacg gctgtgcgcg cccttaagca gctagtcctg   2820

ctccaccgag aggagggcgc gggccccacg cgcaccgtgg agtggctaaa tatgcgcagc   2880

tggtgctcgg ggcacctgca cctgcgctgt ccgcgccgcc tcttttcgcg ccgcagccct   2940

gccaagctgc atgagctcta cgagaaggtt ttctccaggc gcgcggaccg gcacagcgac   3000

ttctcccgct tggcgagggt gctcacgggg aacaccattg cccttgtgct aggcgggggc   3060

ggggccaggg gctgctcgca catcggagta ctaaaggcat tagaggaggc gggggtcccc   3120

gtggacctgg tgggcggcac gtccattggc tctttcatcg gagcgttgta cgcggaggag   3180

cgcagcgcca gccgcacgag gcagcgggcc cgggagtggg ccaagagcat gacttcggtg   3240

ctggaacctg tgttggacct cacgtaccca gtcacctcca tgttcactgg gtctgccttt   3300

aaccgcagca tccatcgggt cttccaggat aagcagattg aggacctgtg gctgccttac   3360

ttcaacgtga ccacagatat caccgcctca gccatgcgag tccacaaaga tggctccctg   3420

tggcggtacg tgcgcgccag catgacgctg tcgggctacc tgcccccgct gtgcgacccc   3480

aaggacgggc acctactcat ggatggcggc tacatcaaca atctgccagc ggacatcgcc   3540

cgcagcatgg gtgccaaaac ggtcatcgcc attgacgtgg ggagccagga tgagacggac   3600

ctcagcacct acggggacag cctgtccggc tggtggctgc tgtggaagcg gctgaatccc   3660

tgggctgaca aggtaaaggt tccagacatg gctgaaatcc agtcccgcct ggcctacgtg   3720

tcctgtgtgc ggcagctaga ggttgtcaag tccagctcct actgcgagta cctgcgcccg   3780

cccatcgact gcttcaagac catggacttt gggaagttcg accagatcta tgatgtgggc   3840

taccagtacg ggaaggcggt gtttggaggc tggagccgtg gcaacgtcat tgagaaaatg   3900

ctcacagacc ggcggtctac agaccttaat gagagccgcc gtgcagacgt gcttgccttc   3960

ccaagctctg gcttcactga cttggcagag attgtgtccc ggattgagcc ccccacgagc   4020

tatgtctctg atggctgtgc tgacggagag gagtcagatt gtctgacaga gtatgaggag   4080

gacgccggac ccgactgctc gagggatgaa ggggggtccc ccgagggcgc aagccccagc   4140

actgcctccg agatggagga ggagaagtcg attctccggc aacgacgctg tctgccccag   4200

gagccgcccg gctcagccac agatgcctga ggacctcgac aggggtcacc ccctccctcc   4260

cacccctgga ctgggctggg ggtggccccg tgggggtagc tcactccccc tcctgctgct   4320

atgcctgtga cccccgcggc ccacacactg gactgacctg ccctgagcgg ggatgcagtg   4380

ttgcactgat gacttgacca gcccctcccc caataaactc gcctcttgga aaaaaaaaaa   4440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                  4471


<210>  3703
<211>  1327
<212>  PRT
<213>  Homosapiens

<400>  3703

Met Glu Ala Pro Leu Gln Thr Gly Met Val Leu Gly Val Met Ile Gly 
1               5                   10                  15      


Ala Gly Val Ala Val Val Val Thr Ala Val Leu Ile Leu Leu Val Val 
            20                  25                  30          


Arg Arg Leu Arg Val Pro Lys Thr Pro Ala Pro Asp Gly Pro Arg Tyr 
        35                  40                  45              


Arg Phe Arg Lys Arg Asp Lys Val Leu Phe Tyr Gly Arg Lys Ile Met 
    50                  55                  60                  


Arg Lys Val Ser Gln Ser Thr Ser Ser Leu Val Asp Thr Ser Val Ser 
65                  70                  75                  80  


Ala Thr Ser Arg Pro Arg Met Arg Lys Lys Leu Lys Met Leu Asn Ile 
                85                  90                  95      


Ala Lys Lys Ile Leu Arg Ile Gln Lys Glu Thr Pro Thr Leu Gln Arg 
            100                 105                 110         


Lys Glu Pro Pro Pro Ala Val Leu Glu Ala Asp Leu Thr Glu Gly Asp 
        115                 120                 125             


Leu Ala Asn Ser His Leu Pro Ser Glu Val Leu Tyr Met Leu Lys Asn 
    130                 135                 140                 


Val Arg Val Leu Gly His Phe Glu Lys Pro Leu Phe Leu Glu Leu Cys 
145                 150                 155                 160 


Arg His Met Val Phe Gln Arg Leu Gly Gln Gly Asp Tyr Val Phe Arg 
                165                 170                 175     


Pro Gly Gln Pro Asp Ala Ser Ile Tyr Val Val Gln Asp Gly Leu Leu 
            180                 185                 190         


Glu Leu Cys Leu Pro Gly Pro Asp Gly Lys Glu Cys Val Val Lys Glu 
        195                 200                 205             


Val Val Pro Gly Asp Ser Val Asn Ser Leu Leu Ser Ile Leu Asp Val 
    210                 215                 220                 


Ile Thr Gly His Gln His Pro Gln Arg Thr Val Ser Ala Arg Ala Ala 
225                 230                 235                 240 


Arg Asp Ser Thr Val Leu Arg Leu Pro Val Glu Ala Phe Ser Ala Val 
                245                 250                 255     


Phe Thr Lys Tyr Pro Glu Ser Leu Val Arg Val Val Gln Ile Ile Met 
            260                 265                 270         


Val Arg Leu Gln Arg Val Thr Phe Leu Ala Leu His Asn Tyr Leu Gly 
        275                 280                 285             


Leu Thr Asn Glu Leu Phe Ser His Glu Ile Gln Pro Leu Arg Leu Phe 
    290                 295                 300                 


Pro Ser Pro Gly Leu Pro Thr Arg Thr Ser Pro Val Arg Gly Ser Lys 
305                 310                 315                 320 


Arg Met Val Ser Thr Ser Ala Thr Asp Glu Pro Arg Glu Thr Pro Gly 
                325                 330                 335     


Arg Pro Pro Asp Pro Thr Gly Ala Pro Leu Pro Gly Pro Thr Gly Asp 
            340                 345                 350         


Pro Val Lys Pro Thr Ser Leu Glu Thr Pro Ser Pro Pro Leu Leu Ser 
        355                 360                 365             


Arg Cys Val Ser Met Pro Gly Asp Ile Ser Gly Leu Gln Gly Gly Pro 
    370                 375                 380                 


Arg Ser Asp Phe Asp Met Ala Tyr Glu Arg Gly Arg Ile Ser Val Ser 
385                 390                 395                 400 


Leu Gln Glu Glu Ala Ser Gly Gly Ser Leu Ala Ala Pro Ala Arg Thr 
                405                 410                 415     


Pro Thr Gln Glu Pro Arg Glu Gln Pro Ala Gly Ala Cys Glu Tyr Ser 
            420                 425                 430         


Tyr Cys Glu Asp Glu Ser Ala Thr Gly Gly Cys Pro Phe Gly Pro Tyr 
        435                 440                 445             


Gln Gly Arg Gln Thr Ser Ser Ile Phe Glu Ala Ala Lys Gln Glu Leu 
    450                 455                 460                 


Ala Lys Leu Met Arg Ile Glu Asp Pro Ser Leu Leu Asn Ser Arg Val 
465                 470                 475                 480 


Leu Leu His His Ala Lys Ala Gly Thr Ile Ile Ala Arg Gln Gly Asp 
                485                 490                 495     


Gln Asp Val Ser Leu His Phe Val Leu Trp Gly Cys Leu His Val Tyr 
            500                 505                 510         


Gln Arg Met Ile Asp Lys Ala Glu Asp Val Cys Leu Phe Val Ala Gln 
        515                 520                 525             


Pro Gly Glu Leu Val Gly Gln Leu Ala Val Leu Thr Gly Glu Pro Leu 
    530                 535                 540                 


Ile Phe Thr Leu Arg Ala Gln Arg Asp Cys Thr Phe Leu Arg Ile Ser 
545                 550                 555                 560 


Lys Ser Asp Phe Tyr Glu Ile Met Arg Ala Gln Pro Ser Val Val Leu 
                565                 570                 575     


Ser Ala Ala His Thr Val Ala Ala Arg Met Ser Pro Phe Val Arg Gln 
            580                 585                 590         


Met Asp Phe Ala Ile Asp Trp Thr Ala Val Glu Ala Gly Arg Ala Leu 
        595                 600                 605             


Tyr Arg Gln Gly Asp Arg Ser Asp Cys Thr Tyr Ile Val Leu Asn Gly 
    610                 615                 620                 


Arg Leu Arg Ser Val Ile Gln Arg Gly Ser Gly Lys Lys Glu Leu Val 
625                 630                 635                 640 


Gly Glu Tyr Gly Arg Gly Asp Leu Ile Gly Val Val Glu Ala Leu Thr 
                645                 650                 655     


Arg Gln Pro Arg Ala Thr Thr Val His Ala Val Arg Asp Thr Glu Leu 
            660                 665                 670         


Ala Lys Leu Pro Glu Gly Thr Leu Gly His Ile Lys Arg Arg Tyr Pro 
        675                 680                 685             


Gln Val Val Thr Arg Leu Ile His Leu Leu Ser Gln Lys Ile Leu Gly 
    690                 695                 700                 


Asn Leu Gln Gln Leu Gln Gly Pro Phe Pro Ala Gly Ser Gly Leu Gly 
705                 710                 715                 720 


Val Pro Pro His Ser Glu Leu Thr Asn Pro Ala Ser Asn Leu Ala Thr 
                725                 730                 735     


Val Ala Ile Leu Pro Val Cys Ala Glu Val Pro Met Val Ala Phe Thr 
            740                 745                 750         


Leu Glu Leu Gln His Ala Leu Gln Ala Ile Gly Pro Thr Leu Leu Leu 
        755                 760                 765             


Asn Ser Asp Ile Ile Arg Ala Arg Leu Gly Ala Ser Ala Leu Asp Ser 
    770                 775                 780                 


Ile Gln Glu Phe Arg Leu Ser Gly Trp Leu Ala Gln Gln Glu Asp Ala 
785                 790                 795                 800 


His Arg Ile Val Leu Tyr Gln Thr Asp Ala Ser Leu Thr Pro Trp Thr 
                805                 810                 815     


Val Arg Cys Leu Arg Gln Ala Asp Cys Ile Leu Ile Val Gly Leu Gly 
            820                 825                 830         


Asp Gln Glu Pro Thr Leu Gly Gln Leu Glu Gln Met Leu Glu Asn Thr 
        835                 840                 845             


Ala Val Arg Ala Leu Lys Gln Leu Val Leu Leu His Arg Glu Glu Gly 
    850                 855                 860                 


Ala Gly Pro Thr Arg Thr Val Glu Trp Leu Asn Met Arg Ser Trp Cys 
865                 870                 875                 880 


Ser Gly His Leu His Leu Arg Cys Pro Arg Arg Leu Phe Ser Arg Arg 
                885                 890                 895     


Ser Pro Ala Lys Leu His Glu Leu Tyr Glu Lys Val Phe Ser Arg Arg 
            900                 905                 910         


Ala Asp Arg His Ser Asp Phe Ser Arg Leu Ala Arg Val Leu Thr Gly 
        915                 920                 925             


Asn Thr Ile Ala Leu Val Leu Gly Gly Gly Gly Ala Arg Gly Cys Ser 
    930                 935                 940                 


His Ile Gly Val Leu Lys Ala Leu Glu Glu Ala Gly Val Pro Val Asp 
945                 950                 955                 960 


Leu Val Gly Gly Thr Ser Ile Gly Ser Phe Ile Gly Ala Leu Tyr Ala 
                965                 970                 975     


Glu Glu Arg Ser Ala Ser Arg Thr Arg Gln Arg Ala Arg Glu Trp Ala 
            980                 985                 990         


Lys Ser Met Thr Ser Val Leu Glu  Pro Val Leu Asp Leu  Thr Tyr Pro 
        995                 1000                 1005             


Val Thr  Ser Met Phe Thr Gly  Ser Ala Phe Asn Arg  Ser Ile His 
    1010                 1015                 1020             


Arg Val  Phe Gln Asp Lys Gln  Ile Glu Asp Leu Trp  Leu Pro Tyr 
    1025                 1030                 1035             


Phe Asn  Val Thr Thr Asp Ile  Thr Ala Ser Ala Met  Arg Val His 
    1040                 1045                 1050             


Lys Asp  Gly Ser Leu Trp Arg  Tyr Val Arg Ala Ser  Met Thr Leu 
    1055                 1060                 1065             


Ser Gly  Tyr Leu Pro Pro Leu  Cys Asp Pro Lys Asp  Gly His Leu 
    1070                 1075                 1080             


Leu Met  Asp Gly Gly Tyr Ile  Asn Asn Leu Pro Ala  Asp Ile Ala 
    1085                 1090                 1095             


Arg Ser  Met Gly Ala Lys Thr  Val Ile Ala Ile Asp  Val Gly Ser 
    1100                 1105                 1110             


Gln Asp  Glu Thr Asp Leu Ser  Thr Tyr Gly Asp Ser  Leu Ser Gly 
    1115                 1120                 1125             


Trp Trp  Leu Leu Trp Lys Arg  Leu Asn Pro Trp Ala  Asp Lys Val 
    1130                 1135                 1140             


Lys Val  Pro Asp Met Ala Glu  Ile Gln Ser Arg Leu  Ala Tyr Val 
    1145                 1150                 1155             


Ser Cys  Val Arg Gln Leu Glu  Val Val Lys Ser Ser  Ser Tyr Cys 
    1160                 1165                 1170             


Glu Tyr  Leu Arg Pro Pro Ile  Asp Cys Phe Lys Thr  Met Asp Phe 
    1175                 1180                 1185             


Gly Lys  Phe Asp Gln Ile Tyr  Asp Val Gly Tyr Gln  Tyr Gly Lys 
    1190                 1195                 1200             


Ala Val  Phe Gly Gly Trp Ser  Arg Gly Asn Val Ile  Glu Lys Met 
    1205                 1210                 1215             


Leu Thr  Asp Arg Arg Ser Thr  Asp Leu Asn Glu Ser  Arg Arg Ala 
    1220                 1225                 1230             


Asp Val  Leu Ala Phe Pro Ser  Ser Gly Phe Thr Asp  Leu Ala Glu 
    1235                 1240                 1245             


Ile Val  Ser Arg Ile Glu Pro  Pro Thr Ser Tyr Val  Ser Asp Gly 
    1250                 1255                 1260             


Cys Ala  Asp Gly Glu Glu Ser  Asp Cys Leu Thr Glu  Tyr Glu Glu 
    1265                 1270                 1275             


Asp Ala  Gly Pro Asp Cys Ser  Arg Asp Glu Gly Gly  Ser Pro Glu 
    1280                 1285                 1290             


Gly Ala  Ser Pro Ser Thr Ala  Ser Glu Met Glu Glu  Glu Lys Ser 
    1295                 1300                 1305             


Ile Leu  Arg Gln Arg Arg Cys  Leu Pro Gln Glu Pro  Pro Gly Ser 
    1310                 1315                 1320             


Ala Thr  Asp Ala 
    1325         


<210>  3704
<211>  4084
<212>  DNA
<213>  Homosapiens

<400>  3704
atgcagaaat ttctagaaaa gggtggtaac ttctgggtga ctgccatgga aacgggtgtg     60

cccgagatca agtcgctgga ccagtacgat ttctcgcggg ccaaggcggc ggccagcctg    120

gcgtgggtgc tgcgggccgc gttcgggggc gcagagcacg tgcccccgga gctgtgggag    180

cccttctata ccgaccagta cgcgcaggag catgtgaagc ccccggtgac acggctgctg    240

ctctcagccg agctctactg cagagcctgg cgccaggcac tgccacagct tgaaacaccc    300

cccaacccct ctgcactgct ggccctgctg gcgcggaggg gcacagtgcc tgctttgccc    360

gagcgcccgg tgcgcgaggc cgacctgagg caccagccca ttctcatggg agcccaccta    420

gctgtcattg atgccctcat ggctgccttt gccttcgagt ggacaaagac cctgccaggt    480

cccttggccc tgaccagctt ggagcacaag ctgcttttct gggtggacac gaccgtccgg    540

cggctgcagg agaagaccga gcaggaagcg gcccagcgag cctctccagc agcccctgca    600

gacggggcgg ccccggcgca gccctcgtgc cctacgcgct ggtactggaa gctggttcct    660

cacgcaattg ccttctgttt gaaggagtcg gggagcaaac cccccatgat ccgataccgc    720

aaggaccgtg tggtggcgcg acgtgccccc tgcttcccga cggtgaccag cctccaggac    780

ctggccagtg gggccgcgct ggccgccacc atccactgct attgtcccca gctgcttcga    840

cttgaggagg tgtgcttgaa ggaccccatg tctgtggcgg acagcctgta caacctccag    900

ctcgtgcagg atttctgtgc ctctcgcctt cctcgtggct gccccctgtc ccttgaggac    960

ttgctgtacg tcccaccgcc actcaaggtc aacttggtgg tgatgctggc cgagttgttc   1020

atgtgttttg aggtgctcaa gcccgacttt gtgcaagtga aggacttgcc cgatggtcac   1080

gctgcctccc cccggggcac tgaggcctcc ccacctcaga acaacagcgg cagtagttct   1140

cctgtcttca ccttccgcca cccgcttctg tcatctggtg gcccccagtc cccactccga   1200

ggatccacag gctccctgaa gtcttccccg tccatgtccc atatggaggc cctgggcaag   1260

gcctggaacc ggcagctcag ccgtcccctc tcccaggctg tgtcattcag cacccccttt   1320

ggcctggaca gcgacgtgga tgtcgtcatg ggagaccctg tgctcctccg ctctgtgagc   1380

tcggacagcc tgggcccccc gcgtcccgcg ccggccagga cccccaccca gccacccccg   1440

gagcctggtg acctgcccac catcgaggaa gctctgcaga tcatccacag tgccgagccc   1500

cggctcctcc cagatggggc ggccgacggc agcttctacc tccactcccc tgaggggccc   1560

tccaagccat ccctggcctc cccctacctg cccgagggga cctccaaacc actgtccgac   1620

aggcccacca aagcaccagt gtacatgcca caccccgaga ccccctcgaa accatctccc   1680

tgtctggtgg gggaggcatc gaaaccgcca gccccatccg aggggtcccc gaaggcggtg   1740

gcttcgtccc cagcagccac caactccgag gtgaaaatga ccagctttgc agaacgcaag   1800

aaacagctgg tgaaggcaga ggctgaggcc ggagcggggt cccccacgtc cactccggcc   1860

ccgccggagg ccctgagctc ggagatgagt gagctcagcg cccggctgga ggagaaacgc   1920

agagccatcg aggctcagaa gcgacggatt gaggccatat tcgccaagca ccgccagcgg   1980

ctgggcaaaa gcgccttcct gcaggtgcag ccgcgggaag cctctgggga ggcggaagca   2040

gaggcggagg aggccgattc cggtccagtc cctggtgggg agcggcccgc aggcgagggc   2100

cagggtgagc caacctcacg gcccaaggca gtgaccttct cgccagacct gggcccggtg   2160

ccccacgagg ggctggggga atacaatcga gcggtcagca agctgagtgc cgccttgagc   2220

tcgctgcagc gggacatgca gaggctcacg gaccagcagc agcggctcct ggccccgccc   2280

gaggcccccg gatccgcccc accacctgct gcgtgggtca tccctggccc cacgacgggg   2340

cccaaagctg catcccccag ccccgcccgg cgagtcccgg ccacccggcg cagccctggg   2400

cccgggccca gccagtcacc ccgcagcccg aaacacacgc ggccagcgga gctgcggctg   2460

gcacccttga ccagggtgct tacgccaccc cacgacgtag acagcctccc ccacctgcgc   2520

aagttctcgc cgagccaggt gcccgtgcag acgcgctctt ccatcctcct ggcggaggag   2580

acgccccccg aggagccagc cgcccggccg ggcctcatcg agatcccgct gggcagcctg   2640

gcagatcccg ccgccgagga cgagggagac gggagccccg ctggtgctga ggattccttg   2700

gaggaggagg cgtcttcgga gggggagccc cgggtggggc tggggttctt ctacaaggat   2760

gaagacaagc ctgaggacga gatggcccaa aagcgggcca gcctgctgga gcggcagcag   2820

cggcgagcag aggaggcgcg gcggcgcaag cagtggcagg aggtggagaa ggaacagcgg   2880

agggaggagg ccgcgaggct ggcccaagag gaggccccgg gcccagcccc gcttgtgtcc   2940

gcagtcccga tggcgactcc agcccctgct gcccgggctc cagccgagga ggaggtgggc   3000

ccccggaagg gggacttcac gcggcaggag tacgagcgcc gggcccagct gaagctgatg   3060

gacgacctcg ataaggtgct gcggccccgg gctgcggggt ccgggggtcc aggtcggggc   3120

gggcggaggg ccacccggcc tcgctcgggt tgctgtgacg actcagccct ggcacgaagc   3180

ccagcccgcg gcctgctggg ctctcggctg agcaaaatct attcccagtc caccctgtca   3240

ctgtccactg tggccaacga ggcccacaat aacctcgggg tgaagaggcc cacgtctcgg   3300

gctccctccc cgtcaggtct catgtcccca agccgcctgc ctggaagccg cgaacgggac   3360

tgggaaaatg gcagcaatgc ctcctcccca gcgtcagtgc ccgagtacac aggtccacgg   3420

ctgtacaaag aacccagcgc caagtccaac aagttcatca tccacaatgc cctatcacac   3480

tgctgcctgg cgggcaaggt gaacgaaccg cagaagaatc gcattctgga ggaaattgag   3540

aaaagcaagg ccaaccactt cctgatcctc tttcgcgact cgagctgcca gttccgggcg   3600

ctctacacgc tgtcggggga gacagaggag ctgtcgcggc tggcagggta tgggccccgg   3660

accgtcacgc ccgccatggt ggaaggcatc tacaagtaca actcggaccg caagcgcttc   3720

acccagatcc ccgccaagac catgtccatg agcgtcgatg ccttcaccat ccagggacac   3780

ctctggcagg gcaagaaacc caccactccc aagaagggcg gcggcacccc caaatagccc   3840

cacccgggcg gtccacgggc cgggccctgt gtgctgcggc cgccatcccc tggaggacag   3900

tcagtcggta ttcctgggtc ctgtctgtcc ccaaccgtgt ctgggtgggg ctggagtctc   3960

caccctctga ctttgagtcc agtcctgctg tgggggctga gctgggaggt tcagggactc   4020

agggctcagc tcagtcccct tgtctgtcct cccccacttc ttgaataaaa taatttaaag   4080

agaa                                                                4084


<210>  3705
<211>  1278
<212>  PRT
<213>  Homosapiens

<400>  3705

Met Gln Lys Phe Leu Glu Lys Gly Gly Asn Phe Trp Val Thr Ala Met 
1               5                   10                  15      


Glu Thr Gly Val Pro Glu Ile Lys Ser Leu Asp Gln Tyr Asp Phe Ser 
            20                  25                  30          


Arg Ala Lys Ala Ala Ala Ser Leu Ala Trp Val Leu Arg Ala Ala Phe 
        35                  40                  45              


Gly Gly Ala Glu His Val Pro Pro Glu Leu Trp Glu Pro Phe Tyr Thr 
    50                  55                  60                  


Asp Gln Tyr Ala Gln Glu His Val Lys Pro Pro Val Thr Arg Leu Leu 
65                  70                  75                  80  


Leu Ser Ala Glu Leu Tyr Cys Arg Ala Trp Arg Gln Ala Leu Pro Gln 
                85                  90                  95      


Leu Glu Thr Pro Pro Asn Pro Ser Ala Leu Leu Ala Leu Leu Ala Arg 
            100                 105                 110         


Arg Gly Thr Val Pro Ala Leu Pro Glu Arg Pro Val Arg Glu Ala Asp 
        115                 120                 125             


Leu Arg His Gln Pro Ile Leu Met Gly Ala His Leu Ala Val Ile Asp 
    130                 135                 140                 


Ala Leu Met Ala Ala Phe Ala Phe Glu Trp Thr Lys Thr Leu Pro Gly 
145                 150                 155                 160 


Pro Leu Ala Leu Thr Ser Leu Glu His Lys Leu Leu Phe Trp Val Asp 
                165                 170                 175     


Thr Thr Val Arg Arg Leu Gln Glu Lys Thr Glu Gln Glu Ala Ala Gln 
            180                 185                 190         


Arg Ala Ser Pro Ala Ala Pro Ala Asp Gly Ala Ala Pro Ala Gln Pro 
        195                 200                 205             


Ser Cys Pro Thr Arg Trp Tyr Trp Lys Leu Val Pro His Ala Ile Ala 
    210                 215                 220                 


Phe Cys Leu Lys Glu Ser Gly Ser Lys Pro Pro Met Ile Arg Tyr Arg 
225                 230                 235                 240 


Lys Asp Arg Val Val Ala Arg Arg Ala Pro Cys Phe Pro Thr Val Thr 
                245                 250                 255     


Ser Leu Gln Asp Leu Ala Ser Gly Ala Ala Leu Ala Ala Thr Ile His 
            260                 265                 270         


Cys Tyr Cys Pro Gln Leu Leu Arg Leu Glu Glu Val Cys Leu Lys Asp 
        275                 280                 285             


Pro Met Ser Val Ala Asp Ser Leu Tyr Asn Leu Gln Leu Val Gln Asp 
    290                 295                 300                 


Phe Cys Ala Ser Arg Leu Pro Arg Gly Cys Pro Leu Ser Leu Glu Asp 
305                 310                 315                 320 


Leu Leu Tyr Val Pro Pro Pro Leu Lys Val Asn Leu Val Val Met Leu 
                325                 330                 335     


Ala Glu Leu Phe Met Cys Phe Glu Val Leu Lys Pro Asp Phe Val Gln 
            340                 345                 350         


Val Lys Asp Leu Pro Asp Gly His Ala Ala Ser Pro Arg Gly Thr Glu 
        355                 360                 365             


Ala Ser Pro Pro Gln Asn Asn Ser Gly Ser Ser Ser Pro Val Phe Thr 
    370                 375                 380                 


Phe Arg His Pro Leu Leu Ser Ser Gly Gly Pro Gln Ser Pro Leu Arg 
385                 390                 395                 400 


Gly Ser Thr Gly Ser Leu Lys Ser Ser Pro Ser Met Ser His Met Glu 
                405                 410                 415     


Ala Leu Gly Lys Ala Trp Asn Arg Gln Leu Ser Arg Pro Leu Ser Gln 
            420                 425                 430         


Ala Val Ser Phe Ser Thr Pro Phe Gly Leu Asp Ser Asp Val Asp Val 
        435                 440                 445             


Val Met Gly Asp Pro Val Leu Leu Arg Ser Val Ser Ser Asp Ser Leu 
    450                 455                 460                 


Gly Pro Pro Arg Pro Ala Pro Ala Arg Thr Pro Thr Gln Pro Pro Pro 
465                 470                 475                 480 


Glu Pro Gly Asp Leu Pro Thr Ile Glu Glu Ala Leu Gln Ile Ile His 
                485                 490                 495     


Ser Ala Glu Pro Arg Leu Leu Pro Asp Gly Ala Ala Asp Gly Ser Phe 
            500                 505                 510         


Tyr Leu His Ser Pro Glu Gly Pro Ser Lys Pro Ser Leu Ala Ser Pro 
        515                 520                 525             


Tyr Leu Pro Glu Gly Thr Ser Lys Pro Leu Ser Asp Arg Pro Thr Lys 
    530                 535                 540                 


Ala Pro Val Tyr Met Pro His Pro Glu Thr Pro Ser Lys Pro Ser Pro 
545                 550                 555                 560 


Cys Leu Val Gly Glu Ala Ser Lys Pro Pro Ala Pro Ser Glu Gly Ser 
                565                 570                 575     


Pro Lys Ala Val Ala Ser Ser Pro Ala Ala Thr Asn Ser Glu Val Lys 
            580                 585                 590         


Met Thr Ser Phe Ala Glu Arg Lys Lys Gln Leu Val Lys Ala Glu Ala 
        595                 600                 605             


Glu Ala Gly Ala Gly Ser Pro Thr Ser Thr Pro Ala Pro Pro Glu Ala 
    610                 615                 620                 


Leu Ser Ser Glu Met Ser Glu Leu Ser Ala Arg Leu Glu Glu Lys Arg 
625                 630                 635                 640 


Arg Ala Ile Glu Ala Gln Lys Arg Arg Ile Glu Ala Ile Phe Ala Lys 
                645                 650                 655     


His Arg Gln Arg Leu Gly Lys Ser Ala Phe Leu Gln Val Gln Pro Arg 
            660                 665                 670         


Glu Ala Ser Gly Glu Ala Glu Ala Glu Ala Glu Glu Ala Asp Ser Gly 
        675                 680                 685             


Pro Val Pro Gly Gly Glu Arg Pro Ala Gly Glu Gly Gln Gly Glu Pro 
    690                 695                 700                 


Thr Ser Arg Pro Lys Ala Val Thr Phe Ser Pro Asp Leu Gly Pro Val 
705                 710                 715                 720 


Pro His Glu Gly Leu Gly Glu Tyr Asn Arg Ala Val Ser Lys Leu Ser 
                725                 730                 735     


Ala Ala Leu Ser Ser Leu Gln Arg Asp Met Gln Arg Leu Thr Asp Gln 
            740                 745                 750         


Gln Gln Arg Leu Leu Ala Pro Pro Glu Ala Pro Gly Ser Ala Pro Pro 
        755                 760                 765             


Pro Ala Ala Trp Val Ile Pro Gly Pro Thr Thr Gly Pro Lys Ala Ala 
    770                 775                 780                 


Ser Pro Ser Pro Ala Arg Arg Val Pro Ala Thr Arg Arg Ser Pro Gly 
785                 790                 795                 800 


Pro Gly Pro Ser Gln Ser Pro Arg Ser Pro Lys His Thr Arg Pro Ala 
                805                 810                 815     


Glu Leu Arg Leu Ala Pro Leu Thr Arg Val Leu Thr Pro Pro His Asp 
            820                 825                 830         


Val Asp Ser Leu Pro His Leu Arg Lys Phe Ser Pro Ser Gln Val Pro 
        835                 840                 845             


Val Gln Thr Arg Ser Ser Ile Leu Leu Ala Glu Glu Thr Pro Pro Glu 
    850                 855                 860                 


Glu Pro Ala Ala Arg Pro Gly Leu Ile Glu Ile Pro Leu Gly Ser Leu 
865                 870                 875                 880 


Ala Asp Pro Ala Ala Glu Asp Glu Gly Asp Gly Ser Pro Ala Gly Ala 
                885                 890                 895     


Glu Asp Ser Leu Glu Glu Glu Ala Ser Ser Glu Gly Glu Pro Arg Val 
            900                 905                 910         


Gly Leu Gly Phe Phe Tyr Lys Asp Glu Asp Lys Pro Glu Asp Glu Met 
        915                 920                 925             


Ala Gln Lys Arg Ala Ser Leu Leu Glu Arg Gln Gln Arg Arg Ala Glu 
    930                 935                 940                 


Glu Ala Arg Arg Arg Lys Gln Trp Gln Glu Val Glu Lys Glu Gln Arg 
945                 950                 955                 960 


Arg Glu Glu Ala Ala Arg Leu Ala Gln Glu Glu Ala Pro Gly Pro Ala 
                965                 970                 975     


Pro Leu Val Ser Ala Val Pro Met Ala Thr Pro Ala Pro Ala Ala Arg 
            980                 985                 990         


Ala Pro Ala Glu Glu Glu Val Gly  Pro Arg Lys Gly Asp  Phe Thr Arg 
        995                 1000                 1005             


Gln Glu  Tyr Glu Arg Arg Ala  Gln Leu Lys Leu Met  Asp Asp Leu 
    1010                 1015                 1020             


Asp Lys  Val Leu Arg Pro Arg  Ala Ala Gly Ser Gly  Gly Pro Gly 
    1025                 1030                 1035             


Arg Gly  Gly Arg Arg Ala Thr  Arg Pro Arg Ser Gly  Cys Cys Asp 
    1040                 1045                 1050             


Asp Ser  Ala Leu Ala Arg Ser  Pro Ala Arg Gly Leu  Leu Gly Ser 
    1055                 1060                 1065             


Arg Leu  Ser Lys Ile Tyr Ser  Gln Ser Thr Leu Ser  Leu Ser Thr 
    1070                 1075                 1080             


Val Ala  Asn Glu Ala His Asn  Asn Leu Gly Val Lys  Arg Pro Thr 
    1085                 1090                 1095             


Ser Arg  Ala Pro Ser Pro Ser  Gly Leu Met Ser Pro  Ser Arg Leu 
    1100                 1105                 1110             


Pro Gly  Ser Arg Glu Arg Asp  Trp Glu Asn Gly Ser  Asn Ala Ser 
    1115                 1120                 1125             


Ser Pro  Ala Ser Val Pro Glu  Tyr Thr Gly Pro Arg  Leu Tyr Lys 
    1130                 1135                 1140             


Glu Pro  Ser Ala Lys Ser Asn  Lys Phe Ile Ile His  Asn Ala Leu 
    1145                 1150                 1155             


Ser His  Cys Cys Leu Ala Gly  Lys Val Asn Glu Pro  Gln Lys Asn 
    1160                 1165                 1170             


Arg Ile  Leu Glu Glu Ile Glu  Lys Ser Lys Ala Asn  His Phe Leu 
    1175                 1180                 1185             


Ile Leu  Phe Arg Asp Ser Ser  Cys Gln Phe Arg Ala  Leu Tyr Thr 
    1190                 1195                 1200             


Leu Ser  Gly Glu Thr Glu Glu  Leu Ser Arg Leu Ala  Gly Tyr Gly 
    1205                 1210                 1215             


Pro Arg  Thr Val Thr Pro Ala  Met Val Glu Gly Ile  Tyr Lys Tyr 
    1220                 1225                 1230             


Asn Ser  Asp Arg Lys Arg Phe  Thr Gln Ile Pro Ala  Lys Thr Met 
    1235                 1240                 1245             


Ser Met  Ser Val Asp Ala Phe  Thr Ile Gln Gly His  Leu Trp Gln 
    1250                 1255                 1260             


Gly Lys  Lys Pro Thr Thr Pro  Lys Lys Gly Gly Gly  Thr Pro Lys 
    1265                 1270                 1275             


<210>  3706
<211>  2682
<212>  DNA
<213>  Homosapiens

<400>  3706
tctcctgtac ctgggcatcc agaaaaatgg tggtgatggc gcgactctcg cggcccgagc     60

ggccggacct tgtcttcgag gaagaggacc tcccctatga ggaggaaatc atgcggaacc    120

aattctctgt caaatgctgg cttcgctaca tcgagttcaa acagggcgcc ccgaagccca    180

ggctcaatca gctatacgag cgggcactca agctgctgcc ctgcagctac aaactctggt    240

accgatacct gaaggcgcgt cgggcacagg tgaagcatcg ctgtgtgacc gaccctgcct    300

atgaagatgt caacaactgt catgagaggg cctttgtgtt catgcacaag atgcctcgtc    360

tgtggctaga ttactgccag ttcctcatgg accaggggcg cgtcacacac acccgccgca    420

ccttcgaccg tgccctccgg gcactgccca tcacgcagca ctctcgaatt tggcccctgt    480

atctgcgctt cctgcgctca cacccactgc ctgagacagc tgtgcgaggc tatcggcgct    540

tcctcaagct gagtcctgag agtgcagagg agtacattga gtacctcaag tcaagtgacc    600

ggctggatga ggccgcccag cgcctggcca ccgtggtgaa cgacgagcgt ttcgtgtcta    660

aggccggcaa gtccaactac cagctgtggc acgagctgtg cgacctcatc tcccagaatc    720

cggacaaggt acagtccctc aatgtggacg ccatcatccg cgggggcctc acccgcttca    780

ccgaccagct gggcaagctc tggtgttctc tcgccgacta ctacatccgc agcggccatt    840

tcgagaaggc tcgggacgtg tacgaggagg ccatccggac agtgatgacc gtgcgggact    900

tcacacaggt gtttgacagc tacgcccagt tcgaggagag catgatcgct gcaaagatgg    960

agaccgcctc ggagctgggg cgcgaggagg aggatgatgt ggacctggag ctgcgcctgg   1020

cccgcttcga gcagctcatc agccggcggc ccctgctcct caacagcgtc ttgctgcgcc   1080

aaaacccaca ccacgtgcac gagtggcaca agcgtgtcgc cctgcaccag ggccgccccc   1140

gggagatcat caacacctac acagaggctg tgcagacggt ggaccccttc aaggccacag   1200

gcaagcccca cactctgtgg gtggcgtttg ccaagtttta tgaggacaac ggacagctgg   1260

acgatgcccg tgtcatcctg gagaaggcca ccaaggtgaa cttcaagcag gtggatgacc   1320

tggcaagcgt gtggtgtcag tgcggagagc tggagctccg acacgagaac tacgatgagg   1380

ccttgcggct gctgcgaaag gccacggcgc tgcctgcccg ccgggccgag tactttgatg   1440

gttcagagcc cgtgcagaac cgcgtgtaca agtcactgaa ggtctggtcc atgctcgccg   1500

acctggagga gagcctcggc accttccagt ccaccaaggc cgtgtacgac cgcatcctgg   1560

acctgcgtat cgcaacaccc cagatcgtca tcaactatgc catgttcctg gaggagcaca   1620

agtacttcga ggagagcttc aaggcgtacg agcgcggcat ctcgctgttc aagtggccca   1680

acgtgtccga catctggagc acctacctga ccaaattcat tgcccgctat gggggccgca   1740

agctggagcg ggcacgggac ctgtttgaac aggctctgga cggctgcccc ccaaaatatg   1800

ccaagacctt gtacctgctg tacgcacagc tggaggagga gtggggcctg gcccggcatg   1860

ccatggccgt gtacgagcgt gccaccaggg ccgtggagcc cgcccagcag tatgacatgt   1920

tcaacatcta catcaagcgg gcggccgaga tctatggggt cacccacacc cgcggcatct   1980

accagaaggc cattgaggtg ctgtcggacg agcacgcgcg tgagatgtgc ctgcggtttg   2040

cagacatgga gtgcaagctc ggggagattg accgcgcccg ggccatctac agcttctgct   2100

cccagatctg tgacccccgg acgaccggcg cgttctggca gacgtggaag gactttgagg   2160

tccggcatgg caatgaggac accatcaagg aaatgctgcg tatccggcgc agcgtgcagg   2220

ccacgtacaa cacgcaggtc aacttcatgg cctcgcagat gctcaaggtc tcgggcagtg   2280

ccacgggcac cgtgtctgac ctggcccctg ggcagagtgg catggacgac atgaagctgc   2340

tggaacagcg ggcagagcag ctggcggctg aggcggagcg tgaccagccc ttgcgcgccc   2400

agagcaagat cctgttcgtg aggagtgacg cctcccggga ggagctggca gagctggcac   2460

agcaggtcaa ccccgaggag atccagctgg gcgaggacga ggacgaggac gagatggacc   2520

tggagcccaa cgaggttcgg ctggagcagc agagcgtgcc agccgcagtg tttgggagcc   2580

tgaaggaaga ctgacccgtc cctcccccat cccccctccc caccccctcc ccaatacagc   2640

tacgtttgta catcaaaaaa aaaaaaaaaa aaaaaaaaaa aa                      2682


<210>  3707
<211>  855
<212>  PRT
<213>  Homosapiens

<400>  3707

Met Val Val Met Ala Arg Leu Ser Arg Pro Glu Arg Pro Asp Leu Val 
1               5                   10                  15      


Phe Glu Glu Glu Asp Leu Pro Tyr Glu Glu Glu Ile Met Arg Asn Gln 
            20                  25                  30          


Phe Ser Val Lys Cys Trp Leu Arg Tyr Ile Glu Phe Lys Gln Gly Ala 
        35                  40                  45              


Pro Lys Pro Arg Leu Asn Gln Leu Tyr Glu Arg Ala Leu Lys Leu Leu 
    50                  55                  60                  


Pro Cys Ser Tyr Lys Leu Trp Tyr Arg Tyr Leu Lys Ala Arg Arg Ala 
65                  70                  75                  80  


Gln Val Lys His Arg Cys Val Thr Asp Pro Ala Tyr Glu Asp Val Asn 
                85                  90                  95      


Asn Cys His Glu Arg Ala Phe Val Phe Met His Lys Met Pro Arg Leu 
            100                 105                 110         


Trp Leu Asp Tyr Cys Gln Phe Leu Met Asp Gln Gly Arg Val Thr His 
        115                 120                 125             


Thr Arg Arg Thr Phe Asp Arg Ala Leu Arg Ala Leu Pro Ile Thr Gln 
    130                 135                 140                 


His Ser Arg Ile Trp Pro Leu Tyr Leu Arg Phe Leu Arg Ser His Pro 
145                 150                 155                 160 


Leu Pro Glu Thr Ala Val Arg Gly Tyr Arg Arg Phe Leu Lys Leu Ser 
                165                 170                 175     


Pro Glu Ser Ala Glu Glu Tyr Ile Glu Tyr Leu Lys Ser Ser Asp Arg 
            180                 185                 190         


Leu Asp Glu Ala Ala Gln Arg Leu Ala Thr Val Val Asn Asp Glu Arg 
        195                 200                 205             


Phe Val Ser Lys Ala Gly Lys Ser Asn Tyr Gln Leu Trp His Glu Leu 
    210                 215                 220                 


Cys Asp Leu Ile Ser Gln Asn Pro Asp Lys Val Gln Ser Leu Asn Val 
225                 230                 235                 240 


Asp Ala Ile Ile Arg Gly Gly Leu Thr Arg Phe Thr Asp Gln Leu Gly 
                245                 250                 255     


Lys Leu Trp Cys Ser Leu Ala Asp Tyr Tyr Ile Arg Ser Gly His Phe 
            260                 265                 270         


Glu Lys Ala Arg Asp Val Tyr Glu Glu Ala Ile Arg Thr Val Met Thr 
        275                 280                 285             


Val Arg Asp Phe Thr Gln Val Phe Asp Ser Tyr Ala Gln Phe Glu Glu 
    290                 295                 300                 


Ser Met Ile Ala Ala Lys Met Glu Thr Ala Ser Glu Leu Gly Arg Glu 
305                 310                 315                 320 


Glu Glu Asp Asp Val Asp Leu Glu Leu Arg Leu Ala Arg Phe Glu Gln 
                325                 330                 335     


Leu Ile Ser Arg Arg Pro Leu Leu Leu Asn Ser Val Leu Leu Arg Gln 
            340                 345                 350         


Asn Pro His His Val His Glu Trp His Lys Arg Val Ala Leu His Gln 
        355                 360                 365             


Gly Arg Pro Arg Glu Ile Ile Asn Thr Tyr Thr Glu Ala Val Gln Thr 
    370                 375                 380                 


Val Asp Pro Phe Lys Ala Thr Gly Lys Pro His Thr Leu Trp Val Ala 
385                 390                 395                 400 


Phe Ala Lys Phe Tyr Glu Asp Asn Gly Gln Leu Asp Asp Ala Arg Val 
                405                 410                 415     


Ile Leu Glu Lys Ala Thr Lys Val Asn Phe Lys Gln Val Asp Asp Leu 
            420                 425                 430         


Ala Ser Val Trp Cys Gln Cys Gly Glu Leu Glu Leu Arg His Glu Asn 
        435                 440                 445             


Tyr Asp Glu Ala Leu Arg Leu Leu Arg Lys Ala Thr Ala Leu Pro Ala 
    450                 455                 460                 


Arg Arg Ala Glu Tyr Phe Asp Gly Ser Glu Pro Val Gln Asn Arg Val 
465                 470                 475                 480 


Tyr Lys Ser Leu Lys Val Trp Ser Met Leu Ala Asp Leu Glu Glu Ser 
                485                 490                 495     


Leu Gly Thr Phe Gln Ser Thr Lys Ala Val Tyr Asp Arg Ile Leu Asp 
            500                 505                 510         


Leu Arg Ile Ala Thr Pro Gln Ile Val Ile Asn Tyr Ala Met Phe Leu 
        515                 520                 525             


Glu Glu His Lys Tyr Phe Glu Glu Ser Phe Lys Ala Tyr Glu Arg Gly 
    530                 535                 540                 


Ile Ser Leu Phe Lys Trp Pro Asn Val Ser Asp Ile Trp Ser Thr Tyr 
545                 550                 555                 560 


Leu Thr Lys Phe Ile Ala Arg Tyr Gly Gly Arg Lys Leu Glu Arg Ala 
                565                 570                 575     


Arg Asp Leu Phe Glu Gln Ala Leu Asp Gly Cys Pro Pro Lys Tyr Ala 
            580                 585                 590         


Lys Thr Leu Tyr Leu Leu Tyr Ala Gln Leu Glu Glu Glu Trp Gly Leu 
        595                 600                 605             


Ala Arg His Ala Met Ala Val Tyr Glu Arg Ala Thr Arg Ala Val Glu 
    610                 615                 620                 


Pro Ala Gln Gln Tyr Asp Met Phe Asn Ile Tyr Ile Lys Arg Ala Ala 
625                 630                 635                 640 


Glu Ile Tyr Gly Val Thr His Thr Arg Gly Ile Tyr Gln Lys Ala Ile 
                645                 650                 655     


Glu Val Leu Ser Asp Glu His Ala Arg Glu Met Cys Leu Arg Phe Ala 
            660                 665                 670         


Asp Met Glu Cys Lys Leu Gly Glu Ile Asp Arg Ala Arg Ala Ile Tyr 
        675                 680                 685             


Ser Phe Cys Ser Gln Ile Cys Asp Pro Arg Thr Thr Gly Ala Phe Trp 
    690                 695                 700                 


Gln Thr Trp Lys Asp Phe Glu Val Arg His Gly Asn Glu Asp Thr Ile 
705                 710                 715                 720 


Lys Glu Met Leu Arg Ile Arg Arg Ser Val Gln Ala Thr Tyr Asn Thr 
                725                 730                 735     


Gln Val Asn Phe Met Ala Ser Gln Met Leu Lys Val Ser Gly Ser Ala 
            740                 745                 750         


Thr Gly Thr Val Ser Asp Leu Ala Pro Gly Gln Ser Gly Met Asp Asp 
        755                 760                 765             


Met Lys Leu Leu Glu Gln Arg Ala Glu Gln Leu Ala Ala Glu Ala Glu 
    770                 775                 780                 


Arg Asp Gln Pro Leu Arg Ala Gln Ser Lys Ile Leu Phe Val Arg Ser 
785                 790                 795                 800 


Asp Ala Ser Arg Glu Glu Leu Ala Glu Leu Ala Gln Gln Val Asn Pro 
                805                 810                 815     


Glu Glu Ile Gln Leu Gly Glu Asp Glu Asp Glu Asp Glu Met Asp Leu 
            820                 825                 830         


Glu Pro Asn Glu Val Arg Leu Glu Gln Gln Ser Val Pro Ala Ala Val 
        835                 840                 845             


Phe Gly Ser Leu Lys Glu Asp 
    850                 855 


<210>  3708
<211>  5576
<212>  DNA
<213>  Homosapiens

<400>  3708
gcggccgccg cctgccgggc ctcccctcgc cgcggccggc cgccgcgctc ccgcccgggc     60

gcccagctat gtactccccg tactgcctca cccaggatga gttccacccg ttcatcgagg    120

cactgctgcc tcacgtccgc gctttctcct acacctggtt caacctgcag gcgcggaagc    180

gcaagtactt caagaagcat gaaaagcgga tgtcgaagga cgaggagcgg gcggtgaagg    240

acgagctgct gggcgagaag cccgagatca agcagaagtg ggcatcccgg ctgctggcca    300

agctgcgcaa ggacatccgg cccgagttcc gcgaggactt cgtgctgacc atcacgggca    360

agaagccccc ctgctgcgtg ctctccaacc ccgaccagaa gggcaagatc cggcggattg    420

actgcctgcg ccaggctgac aaggtgtggc ggctggacct ggtcatggtg attttgttta    480

aggggatccc cctggaaagt actgatgggg agcggctcta caagtcgcct cagtgctcga    540

accccggcct gtgcgtccag ccacatcaca ttggagtcac aatcaaagaa ctggatcttt    600

atctggctta ctttgtccac actccggaat ccggacaatc agatagttca aaccagcaag    660

gagatgcgga catcaaacca ctgcccaacg ggcacttaag tttccaggac tgttttgtga    720

cttccggggt ctggaatgtg acggagctgg tgagagtatc acagactcct gttgcaacag    780

catcagggcc caacttctcc ctggcggacc tggagagtcc cagctactac aacatcaacc    840

aggtgaccct ggggcggcgg tccatcacct cccctccttc caccagcacc accaagcgcc    900

ccaagtccat cgatgacagt gagatggaga gccctgttga tgacgtgttc tatcccggga    960

caggccgttc cccagcagct ggcagcagcc agtccagcgg gtggcccaac gatgtggatg   1020

caggcccggc ttctctaaag aagtcaggaa agctggactt ctgcagtgcc ctctcctctc   1080

agggcagctc cccgcgcatg gctttcaccc accacccgct gcctgtgctt gctggagtca   1140

gaccagggag cccccgggcc acagcatcag ccctgcactt cccctccacg tccatcatcc   1200

agcagtcgag cccgtatttc acgcacccga ccatccgcta ccaccaccac cacgggcagg   1260

actcactgaa ggagtttgtg cagtttgtgt gctcggatgg ctcgggccag gccaccggac   1320

agcattcgca acgacaggcg cctcctctgc caaccggttt gtcagcatcg gaccccggga   1380

cggcaacttt ctgaacatcc cacagcagtc tcagtcctgg ttcctctgat aagatcgaca   1440

aaagaaacaa caaaatgaga agaagaggtt cctcgaaagg ggggagaaga aattttgaga   1500

atggaaaaat cccccagccc agcccagccc caccgaaaag caaaaattac acgtcgtcag   1560

ccactcagcc cttctctcct ccagcccggg gacccccgcg ggccccagaa gcagcccagt   1620

tctcagagag cccttggaag gggtctcggt ggagctgtgc accagcagcc aagcagaaag   1680

aaacacgcga catggactct gtcaagtaga ggacagaaag caagaaagga tgcagaactg   1740

ccttcctccc cctgaccccg ccccggcctt ctggggaagg aacaaagtcc ccaaacaaag   1800

caaccagcac aattctgaag gggcctggcc tccaccctca ccccttccta ggggaacccc   1860

accctccaca cagccggagc tgccctaggg agcctggagg gccagcttgt aaagatgatg   1920

gggtttagat ccctcaggct ctcccctcca gactccgccc ttccctccct ccctccctcc   1980

ctccctctct gccaaggctc cagcttcttc ccccagctgc tcccgaccag gagggggaga   2040

gcagcctcca cttaccccac cccacccttg ggctaaaagc ccccaggcgg gcagggggtg   2100

acccctggag ctagttgcgt gtcccagaat ggagggtgtt ctgacacccc accctgagcc   2160

gcaagagcag tcctggggcc ctggacccct ctgtacagtc cgtaggaaaa agtcggaatg   2220

ctctcgacgg cctcgtccca gcctgggaca ggcccccttt cccctctctc tgcaggccag   2280

gagggcctcc ttcctgccac gagggagggg agtcgggccc caggtcgccc ccgcccccag   2340

ccctgcatgc aggtgccctc gctccgcccc atcagttcct gcccctgccc ctcatgcaga   2400

ctgccctgct ggggccgggc cggagggtgg agcagaaagg ggaccccgga gccgagcgag   2460

gaggaccagg cagccgccgc tgccgcgcta agccaccacc tgcgcttagg taggcgtcct   2520

gctcgccgac tttcagttcc ttgggagggt gttgggtgtc gtccttttca aaagtgtttt   2580

ggagctttct gtgccccccg actttccccc gcctccccgc cccccacgtg gccacttttc   2640

tctggatttt agctgtaatg tctttactct ttatttaggg gtggggcatt cattgtttgg   2700

gtcttttgct gttggaatgg gaactcctcc tccatttgag caacttggga acaatttggt   2760

aacacaccac aggaagtagc tctccccccc agccccctcc tccctcaagg gagggttggg   2820

gggcctgtcc agagggtctt cagaagcccc cctgggaggg aggggaggat gagcacgccc   2880

agctcccctc cagggtgtga cttggcccct ctggcttgtc tttctgtgcc ttactcctcc   2940

tcctgcgtct cccgttcctg gccccttctt gagtccttgt gcctctctct ttctctctct   3000

ttcttaattg tatgaaaaca caaagcacag gtcaggatcc tctgagagaa aatcaacatt   3060

gcaccacgta ggggtgggct atgggctgta tttattgtga atctagtttg tgaggctgtg   3120

gccccgagct ggcggaggga gggaagagga gggagtgacg ggaggggagg aggtcagcga   3180

cctggggccg tagcggcagg cgaacggtgc ctgctaccca gctggaagcc acaaggtggc   3240

tggctccagg ggcggctttt gttggaagtt gagtgaagcc ctccccctgt cctcagcgtg   3300

cagccctaga ggaccccagg gctgaggggc agtggatcct gcgggagtct cccggggcgt   3360

ggggagtaag gccccggggg tggggggccg ggtgggccgg gcgtgacgcg cggtcaaagt   3420

gcaatgattt ttcagttcgg ttggctaaac agggtcagag ctgagagcga agcagaaggg   3480

gctccctgtc cggcccacgt gccctttccc tcgacgacag tcgagggctc gggctctgtg   3540

ggactgtggg agctagggtc tgcggggcgc ctgcccgggc gaggtcggaa gctgcaggcc   3600

agctgggccc gggccggagc gtgcccggcg gggctgcccg ggcgggcagg gggtgggggc   3660

tgctcctttc ccaagtggtg ttgtgagggg caatgagggc aacaggagat gtggggacgt   3720

gttaggagag aaaaaaaaaa aaacaaaaat atatatgggg gaaattaact tttttttttc   3780

attgaaccaa gtgcaatgca tcagagagtt ttcctatctt tgtatgttaa gagattaaga   3840

aaaaaaaatt ctatttttgt tgtaatgtcc tcgcggctct ggggacgcta aaagaaccgg   3900

gcctgccccg ccctgcgcgg ggataacgaa agctgagtgt ttttcccttt tttttgttcg   3960

tttttagttt tttttttttt aagtcgtttt cctgcgttga cgaggatgat ctggggtttt   4020

tatttgtttc gtcgttcgtt ctgtttcggt gggagggctg aaggaaacgt tcacatttta   4080

gagtttaaaa aaaacacctc gacatttaaa aaatcaacca acacaagatc aaaaaggaaa   4140

aggacgagag aaaaattatt tttaagataa ttaaacataa aaccctggtg cttcttacat   4200

tataaagtac gttttaaaga acccacaaac tattatacat aagtttatga atcaattaaa   4260

tatcctgcac ttgttaggaa tacgcatatc ccttctttgt tgagtttaac ggaacgggac   4320

agcggcgtgc ccccggcggc tggactgctc cggccgcggg tctccccggg cgcccctccc   4380

tggggcccag cacccctcct cgccccatcc ccgtccgggt acgggggcgc ggcaggggtc   4440

cccggcccct cccccgcaga ggtcaatgcc aacgaacaaa cgtcccctcc ctccctccct   4500

ctccgccccg agcgcccttc tttgagccag acgccaactt gaccctcacc agcattatca   4560

ggagcgcgct cagcaagttg gtagtttcct cccccctttc ccggcgcccc tcccgccccc   4620

attcaacatc tctcatccta tccccgaccc cctccgggga acaccgggaa ggctcgacgc   4680

tccaggacag gaccagccac gcagacaggt cgatttgccc aggcccgcgc ccgcacgcac   4740

gcacgcacac ggccccgcac acagccccgc cccaccccgc aaccagccct gtcgactgcc   4800

ttatacaccc gcccccgcgc tggccggccg acctagtgcc ttgttctcac ccccgtgctg   4860

gcggagcgga cgccgcgctc tgggtcccag aggggccggg tggctcagac gacccaccac   4920

tcccccaccc tgaccgtgct gaacagaccc ccccacacga gagaaaataa aggagcaata   4980

aagtcacgag aactttcgtc ccccaatcga gagcccgagg ggcaccccag ccccgcctct   5040

gctccccccc accccaccca ccctcggggc gcccccctcc ccccgcaagc cagcctgggc   5100

cagccccgct tcggcccctc ccgggagatc cgtgcgcccg accagcacca gcatcgcgga   5160

ccgcaaaggc cgcccgtccc gtcaaacaag tttcttctta ggctaagaaa cgcagtatat   5220

acgagtatct ctatatatag tactaatgga tttggtgtgc ttccccctta gcgtccccct   5280

ccctctgctc ctcctccttc agcctggtct ccccctcttc tctgccctcc acccccgtct   5340

ctgcactgag atacataaga aacaagggta gtttactgtc tgttttgttt tctgggtttt   5400

cagtgtccta gcggaatgca agtaggcagc cagcccgtct gttccctctc cgccccgccc   5460

cgccccgccc ccgtcactgc gcttctgtta taccatcttt gcctgactct ctccggcttc   5520

tccattgaat ggctaatgtg tatgtgaaat aaagaaataa agaaaaacaa acgcga       5576


<210>  3709
<211>  441
<212>  PRT
<213>  Homosapiens

<400>  3709

Met Tyr Ser Pro Tyr Cys Leu Thr Gln Asp Glu Phe His Pro Phe Ile 
1               5                   10                  15      


Glu Ala Leu Leu Pro His Val Arg Ala Phe Ser Tyr Thr Trp Phe Asn 
            20                  25                  30          


Leu Gln Ala Arg Lys Arg Lys Tyr Phe Lys Lys His Glu Lys Arg Met 
        35                  40                  45              


Ser Lys Asp Glu Glu Arg Ala Val Lys Asp Glu Leu Leu Gly Glu Lys 
    50                  55                  60                  


Pro Glu Ile Lys Gln Lys Trp Ala Ser Arg Leu Leu Ala Lys Leu Arg 
65                  70                  75                  80  


Lys Asp Ile Arg Pro Glu Phe Arg Glu Asp Phe Val Leu Thr Ile Thr 
                85                  90                  95      


Gly Lys Lys Pro Pro Cys Cys Val Leu Ser Asn Pro Asp Gln Lys Gly 
            100                 105                 110         


Lys Ile Arg Arg Ile Asp Cys Leu Arg Gln Ala Asp Lys Val Trp Arg 
        115                 120                 125             


Leu Asp Leu Val Met Val Ile Leu Phe Lys Gly Ile Pro Leu Glu Ser 
    130                 135                 140                 


Thr Asp Gly Glu Arg Leu Tyr Lys Ser Pro Gln Cys Ser Asn Pro Gly 
145                 150                 155                 160 


Leu Cys Val Gln Pro His His Ile Gly Val Thr Ile Lys Glu Leu Asp 
                165                 170                 175     


Leu Tyr Leu Ala Tyr Phe Val His Thr Pro Glu Ser Gly Gln Ser Asp 
            180                 185                 190         


Ser Ser Asn Gln Gln Gly Asp Ala Asp Ile Lys Pro Leu Pro Asn Gly 
        195                 200                 205             


His Leu Ser Phe Gln Asp Cys Phe Val Thr Ser Gly Val Trp Asn Val 
    210                 215                 220                 


Thr Glu Leu Val Arg Val Ser Gln Thr Pro Val Ala Thr Ala Ser Gly 
225                 230                 235                 240 


Pro Asn Phe Ser Leu Ala Asp Leu Glu Ser Pro Ser Tyr Tyr Asn Ile 
                245                 250                 255     


Asn Gln Val Thr Leu Gly Arg Arg Ser Ile Thr Ser Pro Pro Ser Thr 
            260                 265                 270         


Ser Thr Thr Lys Arg Pro Lys Ser Ile Asp Asp Ser Glu Met Glu Ser 
        275                 280                 285             


Pro Val Asp Asp Val Phe Tyr Pro Gly Thr Gly Arg Ser Pro Ala Ala 
    290                 295                 300                 


Gly Ser Ser Gln Ser Ser Gly Trp Pro Asn Asp Val Asp Ala Gly Pro 
305                 310                 315                 320 


Ala Ser Leu Lys Lys Ser Gly Lys Leu Asp Phe Cys Ser Ala Leu Ser 
                325                 330                 335     


Ser Gln Gly Ser Ser Pro Arg Met Ala Phe Thr His His Pro Leu Pro 
            340                 345                 350         


Val Leu Ala Gly Val Arg Pro Gly Ser Pro Arg Ala Thr Ala Ser Ala 
        355                 360                 365             


Leu His Phe Pro Ser Thr Ser Ile Ile Gln Gln Ser Ser Pro Tyr Phe 
    370                 375                 380                 


Thr His Pro Thr Ile Arg Tyr His His His His Gly Gln Asp Ser Leu 
385                 390                 395                 400 


Lys Glu Phe Val Gln Phe Val Cys Ser Asp Gly Ser Gly Gln Ala Thr 
                405                 410                 415     


Gly Gln His Ser Gln Arg Gln Ala Pro Pro Leu Pro Thr Gly Leu Ser 
            420                 425                 430         


Ala Ser Asp Pro Gly Thr Ala Thr Phe 
        435                 440     


<210>  3710
<211>  1510
<212>  DNA
<213>  Homosapiens

<400>  3710
cagcctggcc cttatctgca ctgggccagc atcctccggc cgctgcgccg ccaggggtga     60

gagggaggaa accgggccgc cgggggcggg gagaaggcgg gccggcccgg gagccgctca    120

ctttccctgg gggggaccta cgcggagacc tcggctatcc tggccttccg aggcccacga    180

ggaggcgcgg cccaacgccg gggcctggag cattgaggcc ggaccctcgc gagacagcag    240

agcctggcct gacgctggaa accacaccct ggcccagact gccagccctg acgggacaga    300

gccagggcac tcaccaggct gcaagaacag tgctggggtg agtaccccca cgtcggggtc    360

catgtgcccg cctcaggcac aggcagaggt gggccccacc atgactgaga aggcagagat    420

ggtgtgtgcc cccagcccag cgcctgcccc accccctaag cctgcctcgc ctgggccccc    480

gcaggtggag gaggtgggcc accgaggagg ctcctcgccc cccaggctgc cacctggtgt    540

accagtgatc agcctgggcc acagcaggcc cccaggggta gccatgccca ccacagagct    600

gggcactctg cggcccccgc tgctgcaact ctccaccctg ggaactgccc cgcccacttt    660

ggccctgcac taccaccctc accccttcct caacagtgtc tacattgggc cagcaggacc    720

ttttagcatc ttccctagca gccggttgaa gcggagacca agccactgtg agctggacct    780

ggctgagggg caccagcccc agaaggtggc ccggcgcgtg ttcaccaaca gccgggagcg    840

ctggcggcag cagaacgtta acggcgcctt cgccgagctg aggaagctgc tgccgacgca    900

cccgcccgac cggaagctga gcaagaacga ggtgctccgc ctagccatga agtacatcgg    960

cttcctggtg cggctgctgc gcgaccaagc cgcagctctg gccgcaggcc ccacccctcc   1020

cgggcctcgc aaacggccgg tgcaccgggt cccagacgac ggcgcccgcc ggggatccgg   1080

acgcagggcc gaggcggcag cgcgctcgca gcccgcgccc ccggccgacc ccgacggcag   1140

ccccggtgga gcggcccggc ccatcaagat ggagcaaacc gctttgagcc cagaggtgcg   1200

gtgaccgcac gcggcagcac ctctgagccg gagggcacca gggactcggc ccagggccgt   1260

caaggaaagg gcagtggacg tgctgcgcat gttcgggagc gaactccccc gaagaaggac   1320

cagtgaagac gtcaggggca aggtctcggg ggtccggaag ggtgatcatc gacccccaag   1380

ggacccgcag acccttaaaa aaatcaccca caaccctctg gaagtggcct tgcccggtcc   1440

ccttcccagg ggcgaggtcg gcaaagcaac atggcagagc agtcatagga aaaaaaaaaa   1500

aaaaaaaaaa                                                          1510


<210>  3711
<211>  280
<212>  PRT
<213>  Homosapiens

<400>  3711

Met Cys Pro Pro Gln Ala Gln Ala Glu Val Gly Pro Thr Met Thr Glu 
1               5                   10                  15      


Lys Ala Glu Met Val Cys Ala Pro Ser Pro Ala Pro Ala Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Ser Pro Gly Pro Pro Gln Val Glu Glu Val Gly His Arg 
        35                  40                  45              


Gly Gly Ser Ser Pro Pro Arg Leu Pro Pro Gly Val Pro Val Ile Ser 
    50                  55                  60                  


Leu Gly His Ser Arg Pro Pro Gly Val Ala Met Pro Thr Thr Glu Leu 
65                  70                  75                  80  


Gly Thr Leu Arg Pro Pro Leu Leu Gln Leu Ser Thr Leu Gly Thr Ala 
                85                  90                  95      


Pro Pro Thr Leu Ala Leu His Tyr His Pro His Pro Phe Leu Asn Ser 
            100                 105                 110         


Val Tyr Ile Gly Pro Ala Gly Pro Phe Ser Ile Phe Pro Ser Ser Arg 
        115                 120                 125             


Leu Lys Arg Arg Pro Ser His Cys Glu Leu Asp Leu Ala Glu Gly His 
    130                 135                 140                 


Gln Pro Gln Lys Val Ala Arg Arg Val Phe Thr Asn Ser Arg Glu Arg 
145                 150                 155                 160 


Trp Arg Gln Gln Asn Val Asn Gly Ala Phe Ala Glu Leu Arg Lys Leu 
                165                 170                 175     


Leu Pro Thr His Pro Pro Asp Arg Lys Leu Ser Lys Asn Glu Val Leu 
            180                 185                 190         


Arg Leu Ala Met Lys Tyr Ile Gly Phe Leu Val Arg Leu Leu Arg Asp 
        195                 200                 205             


Gln Ala Ala Ala Leu Ala Ala Gly Pro Thr Pro Pro Gly Pro Arg Lys 
    210                 215                 220                 


Arg Pro Val His Arg Val Pro Asp Asp Gly Ala Arg Arg Gly Ser Gly 
225                 230                 235                 240 


Arg Arg Ala Glu Ala Ala Ala Arg Ser Gln Pro Ala Pro Pro Ala Asp 
                245                 250                 255     


Pro Asp Gly Ser Pro Gly Gly Ala Ala Arg Pro Ile Lys Met Glu Gln 
            260                 265                 270         


Thr Ala Leu Ser Pro Glu Val Arg 
        275                 280 


<210>  3712
<211>  2217
<212>  DNA
<213>  Homosapiens

<400>  3712
ccctacctca tagatatgta ggacatcccc gggcccggaa tgcggctctc tgaccctctc     60

tgtgccctcc cccgcccccc gaaccaggct tggcgggcgg aggcgccagc ggatgtctca    120

tgcaaggatc gtctctgtgg ctaagcctca ctttccgctc cgcccgggtg ctctctagag    180

cccggttttt cgagtggcag tctccagggc tgccgaatac agcagcgatg gagaacggca    240

ccgggcccta cggagaagaa cgtccacgtg aagtccagga gacgacagtc accgaggggg    300

ctgccaaaat cgcctttccc agtgccaacg aggtctttta taacccggtg caggaattca    360

atcgggacct gacatgtgct gtgatcaccg agtttgctcg cattcagctt ggggccaaag    420

gaatccagat caaggttcca ggagagaagg acacgcaaaa agtggtcgtg gacttgtcag    480

agcaagagga ggaaaaggtt gaactgaaag agagtgaaaa cctggcctca ggagaccaac    540

ctcgcacagc ggccgtgggg gagatctgtg aggaaggcct gcatgtgctg gaaggcctgg    600

cagcttcagg cctacgttcc attcgatttg ccctagaggt gcctgggctc agatctgtgg    660

ttgcaaacga tgcctccacc cgggctgtgg atctcatacg ccggaatgtc cagctcaatg    720

acgtggccca cctggtacag ccgagccaag cagatgcccg gatgctgatg taccagcacc    780

agagggtgtc ggagaggttt gacgtcatcg atctggaccc ctatggcagc ccagccacct    840

tcctggatgc agctgtgcag gctgtgagtg aaggagggtt gctgtgtgtg acctgcacag    900

acatggcggt gttggcgggg aacagcgggg agacgtgcta cagcaagtac ggggccatgg    960

ccctcaagag ccgggcctgc cacgagatgg ccctgagaat cgtcctgcac agcctggacc   1020

tccgcgccaa ctgctaccag cgcttcgtgg tgccgctgct cagcatcagc gctgacttct   1080

acgtgcgtgt ttttgtccgt gtcttcaccg gccaggccaa ggtcaaggcc tcagccagca   1140

agcaggcgct ggtgttccag tgtgtgggct gcggggcctt ccaccttcag cgtctcggca   1200

aagcgtcagg agtccccagc ggccgggcca agttctctgc agcctgtggt ccccctgtga   1260

cccccgagtg tgaacactgt gggcaacgac accagcttgg tggccccatg tgggcagagc   1320

ccatccatga cctggatttt gtgggccgtg tcctggaggc tgtgagcgct aaccccggcc   1380

gcttccacac ctcggagcgg atccgagggg tcctgagcgt catcactgag gagctcccgg   1440

acgtgcctct gtactacacc ctggaccagc tgagcagcac catccactgc aacacaccaa   1500

gcctcctgca gttgcggtcg gccctcctcc acgctgactt ccgggtctca ctctcccacg   1560

cctgtaagaa cgctgtgaag acggatgccc ctgcctctgc cctctgggac atcatgcgtt   1620

gctgggagaa ggaatgtccg gtgaaacggg agcgactatc agagactagc ccagcgttcc   1680

gcattctcag tgtggagccc aggctgcagg ccaacttcac catccgggaa gatgccaacc   1740

ccagctcccg acagcgagga ctcaagcgct tccaggctaa cccggaggcc aactggggtc   1800

cccggcctcg tgcccggcca gggggcaagg cggccgacga agctatggag gagagacgca   1860

ggctgcttca gaacaagcgg aaggagccgc cggaagatgt ggcccagcgg gctgcccggc   1920

tcaagacatt tccttgcaag aggtttaagg agggcacctg tcaacgcggg gaccagtgct   1980

gctactccca cagccccccg acacccaggg tttctgctga tgctgcccct gactgtccag   2040

agacctccaa ccagaccccc cctggacctg gggctgccgc tgggccaggc atagactgaa   2100

ccaataaaga gatgtcacgt caccttctcc cgaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2160

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa      2217


<210>  3713
<211>  659
<212>  PRT
<213>  Homosapiens

<400>  3713

Met Gln Gly Ser Ser Leu Trp Leu Ser Leu Thr Phe Arg Ser Ala Arg 
1               5                   10                  15      


Val Leu Ser Arg Ala Arg Phe Phe Glu Trp Gln Ser Pro Gly Leu Pro 
            20                  25                  30          


Asn Thr Ala Ala Met Glu Asn Gly Thr Gly Pro Tyr Gly Glu Glu Arg 
        35                  40                  45              


Pro Arg Glu Val Gln Glu Thr Thr Val Thr Glu Gly Ala Ala Lys Ile 
    50                  55                  60                  


Ala Phe Pro Ser Ala Asn Glu Val Phe Tyr Asn Pro Val Gln Glu Phe 
65                  70                  75                  80  


Asn Arg Asp Leu Thr Cys Ala Val Ile Thr Glu Phe Ala Arg Ile Gln 
                85                  90                  95      


Leu Gly Ala Lys Gly Ile Gln Ile Lys Val Pro Gly Glu Lys Asp Thr 
            100                 105                 110         


Gln Lys Val Val Val Asp Leu Ser Glu Gln Glu Glu Glu Lys Val Glu 
        115                 120                 125             


Leu Lys Glu Ser Glu Asn Leu Ala Ser Gly Asp Gln Pro Arg Thr Ala 
    130                 135                 140                 


Ala Val Gly Glu Ile Cys Glu Glu Gly Leu His Val Leu Glu Gly Leu 
145                 150                 155                 160 


Ala Ala Ser Gly Leu Arg Ser Ile Arg Phe Ala Leu Glu Val Pro Gly 
                165                 170                 175     


Leu Arg Ser Val Val Ala Asn Asp Ala Ser Thr Arg Ala Val Asp Leu 
            180                 185                 190         


Ile Arg Arg Asn Val Gln Leu Asn Asp Val Ala His Leu Val Gln Pro 
        195                 200                 205             


Ser Gln Ala Asp Ala Arg Met Leu Met Tyr Gln His Gln Arg Val Ser 
    210                 215                 220                 


Glu Arg Phe Asp Val Ile Asp Leu Asp Pro Tyr Gly Ser Pro Ala Thr 
225                 230                 235                 240 


Phe Leu Asp Ala Ala Val Gln Ala Val Ser Glu Gly Gly Leu Leu Cys 
                245                 250                 255     


Val Thr Cys Thr Asp Met Ala Val Leu Ala Gly Asn Ser Gly Glu Thr 
            260                 265                 270         


Cys Tyr Ser Lys Tyr Gly Ala Met Ala Leu Lys Ser Arg Ala Cys His 
        275                 280                 285             


Glu Met Ala Leu Arg Ile Val Leu His Ser Leu Asp Leu Arg Ala Asn 
    290                 295                 300                 


Cys Tyr Gln Arg Phe Val Val Pro Leu Leu Ser Ile Ser Ala Asp Phe 
305                 310                 315                 320 


Tyr Val Arg Val Phe Val Arg Val Phe Thr Gly Gln Ala Lys Val Lys 
                325                 330                 335     


Ala Ser Ala Ser Lys Gln Ala Leu Val Phe Gln Cys Val Gly Cys Gly 
            340                 345                 350         


Ala Phe His Leu Gln Arg Leu Gly Lys Ala Ser Gly Val Pro Ser Gly 
        355                 360                 365             


Arg Ala Lys Phe Ser Ala Ala Cys Gly Pro Pro Val Thr Pro Glu Cys 
    370                 375                 380                 


Glu His Cys Gly Gln Arg His Gln Leu Gly Gly Pro Met Trp Ala Glu 
385                 390                 395                 400 


Pro Ile His Asp Leu Asp Phe Val Gly Arg Val Leu Glu Ala Val Ser 
                405                 410                 415     


Ala Asn Pro Gly Arg Phe His Thr Ser Glu Arg Ile Arg Gly Val Leu 
            420                 425                 430         


Ser Val Ile Thr Glu Glu Leu Pro Asp Val Pro Leu Tyr Tyr Thr Leu 
        435                 440                 445             


Asp Gln Leu Ser Ser Thr Ile His Cys Asn Thr Pro Ser Leu Leu Gln 
    450                 455                 460                 


Leu Arg Ser Ala Leu Leu His Ala Asp Phe Arg Val Ser Leu Ser His 
465                 470                 475                 480 


Ala Cys Lys Asn Ala Val Lys Thr Asp Ala Pro Ala Ser Ala Leu Trp 
                485                 490                 495     


Asp Ile Met Arg Cys Trp Glu Lys Glu Cys Pro Val Lys Arg Glu Arg 
            500                 505                 510         


Leu Ser Glu Thr Ser Pro Ala Phe Arg Ile Leu Ser Val Glu Pro Arg 
        515                 520                 525             


Leu Gln Ala Asn Phe Thr Ile Arg Glu Asp Ala Asn Pro Ser Ser Arg 
    530                 535                 540                 


Gln Arg Gly Leu Lys Arg Phe Gln Ala Asn Pro Glu Ala Asn Trp Gly 
545                 550                 555                 560 


Pro Arg Pro Arg Ala Arg Pro Gly Gly Lys Ala Ala Asp Glu Ala Met 
                565                 570                 575     


Glu Glu Arg Arg Arg Leu Leu Gln Asn Lys Arg Lys Glu Pro Pro Glu 
            580                 585                 590         


Asp Val Ala Gln Arg Ala Ala Arg Leu Lys Thr Phe Pro Cys Lys Arg 
        595                 600                 605             


Phe Lys Glu Gly Thr Cys Gln Arg Gly Asp Gln Cys Cys Tyr Ser His 
    610                 615                 620                 


Ser Pro Pro Thr Pro Arg Val Ser Ala Asp Ala Ala Pro Asp Cys Pro 
625                 630                 635                 640 


Glu Thr Ser Asn Gln Thr Pro Pro Gly Pro Gly Ala Ala Ala Gly Pro 
                645                 650                 655     


Gly Ile Asp 
            


<210>  3714
<211>  4556
<212>  DNA
<213>  Homosapiens

<400>  3714
tggccgccgc ggctgccgct gctgctgagg cggaggccgc ggaggccgcg gaggcggagg     60

ccgaggcccc ggcgcagcgg ggcgcgcccc gggcccaggc ccggccccag ccgccgctgc    120

ggagcccgcc gggacccccc ggagcgcggc cacggcgcag ccgctgccat ggcccagaca    180

ctgcagatgg agatcccgaa cttcggcaac agcatcctgg agtgcctcaa tgaacagcgg    240

ctgcagggcc tgtactgtga cgtgtcagtg gtggtcaagg gccatgcctt caaggcccac    300

cgggccgtgc ttgctgccag cagctcctac ttccgggacc tgttcaacaa cagccgcagc    360

gccgtggtgg agctgccggc ggctgtgcag ccccagtctt tccagcagat cctcagcttc    420

tgctacacgg gccggctgag catgaacgtg ggcgaccagt tcctgctcat gtacacggct    480

ggcttcctgc agatccagga gatcatggag aagggcaccg agttcttcct caaggtgagc    540

tccccgagct gcgactccca gggcctgcat gcggaggagg ccccatcgtc ggagccccag    600

agccccgtgg cgcagacatc gggctggcca gcctgtagca ccccgctgcc cctcgtgtcg    660

cgggtgaaga cggagcagca ggagtcggac tccgtgcagt gcatgcccgt ggccaagcgg    720

ctgtgggaca gtggccagaa ggaggctggg ggcggcggca atggcagccg caagatggcc    780

aagttctcca cgccggacct ggctgccaac cggcctcacc agcccccgcc accccaacag    840

gctccggtgg tggcagcagc ccagcccgcc gtggctgcgg gagcagggca gccagccggt    900

ggggtggcag cagcaggggg tgtggtgagt gggcccagca cgtcggagcg gaccagccca    960

ggcacctcaa gcgcctacac cagcgacagc cctggctcct accacaatga ggaggacgag   1020

gaggaggatg gtggcgagga gggcatggat gagcagtacc ggcagatctg caacatgtac   1080

accatgtaca gcatgatgaa cgtcggccag acagccgaga aggtggaggc cctcccggag   1140

caggtagccc ccgagtcccg aaatcgcatc cgggttcggc aagacctggc gtctctcccg   1200

gctgaactta tcaaccagat tgggaaccgc tgccacccca agctctacga cgagggcgac   1260

ccctctgaga agctggagct ggtgacaggc accaacgtgt acatcacaag ggcgcagctg   1320

atgaactgcc acgtcagcgc aggcacgcgg cacaaggtcc tactgcggcg gctcctggcc   1380

tccttctttg accggaacac gctggccaac agctgcggca ccggcatccg ctcttctacc   1440

aacgatcccc gtcggaagcc cctggacagc cgcgtgctcc acgctgtcaa gtactactgc   1500

cagaacttcg cccccaactt caaggagagc gagatgaatg ccatcgcggc cgacatgtgc   1560

accaacgccc gccgcgtcgt gcgcaagagc tggatgccca aggtcaaggt gctcaaggct   1620

gaggatgacg cctacaccac cttcatcagt gaaacgggca agatcgagcc ggacatgatg   1680

ggtgtggagc atggcttcga gaccgccagc cacgagggcg aggcgggtcc ctcggctgaa   1740

gccctgcagt aacccgccca gcctcccgcg gggccacaca cttcccctcc caacacacac   1800

acacacctgc catcttggtc atgagctact gtctgtccct ccccaggacc cgcggtgggt   1860

gctgcatgtt cccggccctc tgcccctcct gtcctacccc ctttccccac cgagagctgg   1920

gccgggagag gaccgcaggg caggtggcgt gaggtccgtg ttgccttctt taacacacac   1980

tcgtgcagtg ggggagttct ggctccccaa cctaacccct agccgtcatc tccacactca   2040

ccaggcccac caggggaggg ggctggcctg ggggtcttgg gaaggcccct ccccaggccc   2100

taggccacct cgcggaagcc ttcagcctcc gcccctcact gcagcccctt gggacttgag   2160

gggggcccca ggggttctca ggacccctcc caccacctcc cagtgcttcc acgtctccaa   2220

aagcgccttc ctgtcaccct cgtctatccc tgcgcctggg ggctggggta ggcgaggccg   2280

tggggactac ccattttata gctggggaaa caggctccga gaaattgcac aaccgacctc   2340

aggtggccgg cagtggcgtg cctggtgccc tttctcctct tccgcctctg ttgctccctt   2400

tggtcctctg gggcctcaga gaggcaggtc ctaaaggagg gggggtctcc tgggggcaga   2460

ccgagggtct cggaggatag aatgagaggt ttccagggct ggcagagtgt gtgcgtgtgt   2520

gtgtgcagaa gttttgcttt caaacaaatg aagatacaag aggcagtagg acctgggttg   2580

gaacccaggg gagcagactg gggggctgtt gcccctccct ccatctcccc acacccaccc   2640

caccccacag cagggctcct ggcccccacc cccctgtaca taatttttaa aacctttttt   2700

tagcgaatga aatattgaag tataagattc cttttatttt tcaaaccaat ggggctgtgt   2760

ctattgtccc cctcggtccc caggggtggg gggccttgga aggcagggcg gtgttggggg   2820

gctggggggc aggctgaatg tgtgtgtgtg ggtgtgtatg tgtggagtgt gtgtgtgtgt   2880

ttccatggta ggactccagt cccagctgct gcctaggctc ctgtgggtcc tgtgggtccc   2940

cctcccctgt tcaccttccc caacagggct atagtttaag ggtgtcccag gccttggctg   3000

gttggctggg cccagctcct gggggctggg cagggcaggg cagggccggg tccacttcca   3060

ttgttagcag ttgtttgcag aattttctct tttaccattc ctctcttttt gttctcgccc   3120

agagtgggtg gttttttgtt gttgttttag attttcatgt gaaggcagtt ttttttcttt   3180

tttaactccc catcccccta tgcagggtgt catttcacca tccacatcca catccttgtt   3240

tgtgtttctg gccctcgtcc tccctgcctc tcatctgcct ccccaacccc cacctaccca   3300

ctgctcccag gggtctctcc aggggcaggg ggattttagg agatggggtg ggggccagcc   3360

cctactggac ccttgtaatc tgatttggag accatccccc cgatgggacc agcagccccg   3420

ccggcccact gggggtccct cttaacatct gcttgttgcg ggggtcagtc atgagtgcca   3480

gggtctggct ggggtcttgg cactgtcttc ctggccgggg cctgaaacct tagcccccag   3540

ccggcctgag tgggggatat tgacaccccc agctaaagca caagcacctt agtcacccct   3600

cctctccccc cgcctcctgg cctgccaccc caccccagcg tttaccccaa agcacaatgc   3660

cctggtcact tggcaagcgg ctgggcctga cggaggccga ggggcagacc ggggctccag   3720

ccagacccct gaaaggaagg tgctccccca cttccaggcc ttagttgggg tgggggggcc   3780

agctcctggg cctggggtct tctcaccccc acccccttgt cctgggtagg cccctgcctg   3840

cccctctctg ccttttcctc gggtgtccct cctcgagccc ctgtggcatt ggcttgggtg   3900

gcagagccca cttgtttcag ggaccccagg aggtgccccc tggctcccag gactgtgtgt   3960

gggtccgggg ggtggggggg tggggagaag ggtcgggcag ggggtgcagg ggaggaaact   4020

cctcaccagg agagccaaag acagggttgt gccttacccc aggagccacc cctgtacccc   4080

ccttgccctg ccattcaccc tccaccccta cccctgggcg gcctgctgct ttttccttct   4140

cttcctcccc tgccctgagc tgcatggttc ccccaccctg ggcagccagg aaggaatctg   4200

aatggagaat caccaaccac cagagaaaaa agactgtggg gccctcccct gccaactccc   4260

cttccctggc cgcccactca acccacacct ctttcacgca ggacaggctg cccaccctgt   4320

ccacgtgaag tgccaacgcc ctccccaccc tgggccgagc ccccacccct ccctgggccc   4380

ccaagtgaga ttgcacattt aactactgta aggagaggag cggcgttggc aaatgtgaac   4440

catgagaata tcagtgatac tgatgagaat aaactaaacg cctttgtaac aaaaaaaaaa   4500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa       4556


<210>  3715
<211>  527
<212>  PRT
<213>  Homosapiens

<400>  3715

Met Ala Gln Thr Leu Gln Met Glu Ile Pro Asn Phe Gly Asn Ser Ile 
1               5                   10                  15      


Leu Glu Cys Leu Asn Glu Gln Arg Leu Gln Gly Leu Tyr Cys Asp Val 
            20                  25                  30          


Ser Val Val Val Lys Gly His Ala Phe Lys Ala His Arg Ala Val Leu 
        35                  40                  45              


Ala Ala Ser Ser Ser Tyr Phe Arg Asp Leu Phe Asn Asn Ser Arg Ser 
    50                  55                  60                  


Ala Val Val Glu Leu Pro Ala Ala Val Gln Pro Gln Ser Phe Gln Gln 
65                  70                  75                  80  


Ile Leu Ser Phe Cys Tyr Thr Gly Arg Leu Ser Met Asn Val Gly Asp 
                85                  90                  95      


Gln Phe Leu Leu Met Tyr Thr Ala Gly Phe Leu Gln Ile Gln Glu Ile 
            100                 105                 110         


Met Glu Lys Gly Thr Glu Phe Phe Leu Lys Val Ser Ser Pro Ser Cys 
        115                 120                 125             


Asp Ser Gln Gly Leu His Ala Glu Glu Ala Pro Ser Ser Glu Pro Gln 
    130                 135                 140                 


Ser Pro Val Ala Gln Thr Ser Gly Trp Pro Ala Cys Ser Thr Pro Leu 
145                 150                 155                 160 


Pro Leu Val Ser Arg Val Lys Thr Glu Gln Gln Glu Ser Asp Ser Val 
                165                 170                 175     


Gln Cys Met Pro Val Ala Lys Arg Leu Trp Asp Ser Gly Gln Lys Glu 
            180                 185                 190         


Ala Gly Gly Gly Gly Asn Gly Ser Arg Lys Met Ala Lys Phe Ser Thr 
        195                 200                 205             


Pro Asp Leu Ala Ala Asn Arg Pro His Gln Pro Pro Pro Pro Gln Gln 
    210                 215                 220                 


Ala Pro Val Val Ala Ala Ala Gln Pro Ala Val Ala Ala Gly Ala Gly 
225                 230                 235                 240 


Gln Pro Ala Gly Gly Val Ala Ala Ala Gly Gly Val Val Ser Gly Pro 
                245                 250                 255     


Ser Thr Ser Glu Arg Thr Ser Pro Gly Thr Ser Ser Ala Tyr Thr Ser 
            260                 265                 270         


Asp Ser Pro Gly Ser Tyr His Asn Glu Glu Asp Glu Glu Glu Asp Gly 
        275                 280                 285             


Gly Glu Glu Gly Met Asp Glu Gln Tyr Arg Gln Ile Cys Asn Met Tyr 
    290                 295                 300                 


Thr Met Tyr Ser Met Met Asn Val Gly Gln Thr Ala Glu Lys Val Glu 
305                 310                 315                 320 


Ala Leu Pro Glu Gln Val Ala Pro Glu Ser Arg Asn Arg Ile Arg Val 
                325                 330                 335     


Arg Gln Asp Leu Ala Ser Leu Pro Ala Glu Leu Ile Asn Gln Ile Gly 
            340                 345                 350         


Asn Arg Cys His Pro Lys Leu Tyr Asp Glu Gly Asp Pro Ser Glu Lys 
        355                 360                 365             


Leu Glu Leu Val Thr Gly Thr Asn Val Tyr Ile Thr Arg Ala Gln Leu 
    370                 375                 380                 


Met Asn Cys His Val Ser Ala Gly Thr Arg His Lys Val Leu Leu Arg 
385                 390                 395                 400 


Arg Leu Leu Ala Ser Phe Phe Asp Arg Asn Thr Leu Ala Asn Ser Cys 
                405                 410                 415     


Gly Thr Gly Ile Arg Ser Ser Thr Asn Asp Pro Arg Arg Lys Pro Leu 
            420                 425                 430         


Asp Ser Arg Val Leu His Ala Val Lys Tyr Tyr Cys Gln Asn Phe Ala 
        435                 440                 445             


Pro Asn Phe Lys Glu Ser Glu Met Asn Ala Ile Ala Ala Asp Met Cys 
    450                 455                 460                 


Thr Asn Ala Arg Arg Val Val Arg Lys Ser Trp Met Pro Lys Val Lys 
465                 470                 475                 480 


Val Leu Lys Ala Glu Asp Asp Ala Tyr Thr Thr Phe Ile Ser Glu Thr 
                485                 490                 495     


Gly Lys Ile Glu Pro Asp Met Met Gly Val Glu His Gly Phe Glu Thr 
            500                 505                 510         


Ala Ser His Glu Gly Glu Ala Gly Pro Ser Ala Glu Ala Leu Gln 
        515                 520                 525         


<210>  3716
<211>  750
<212>  DNA
<213>  Homosapiens

<400>  3716
atgtctctcg aagacccctt ttttgtagtc cgaggcgagg tgcagaaggc ggtgaacacg     60

gcccgcgggc tgtaccagcg ctggtgcgag ctcctgcagg aaagcgcggc ggtcggacgc    120

gaggagctgg actggacgac caatgagctg cggaatggcc tgcgcagcat cgagtgggac    180

ctcgaggacc tggaagagac catcggtata gtggaagcca acccaggcaa gttcaagctc    240

ccagccgggg acctgcagga gagaaaggtg ttcgtggagc ggatgcgaga ggcagtccag    300

gaaatgaagg accatatggt cagcccaaca gccgtagcat ttttggagag gaataacaga    360

gagatactcg caggcaagcc agctgcccag aagtcaccca gcgacctgct ggatgccagc    420

gcagtctcgg ccacatctcg ctacatcgag gagcagcagg ccacacagca gctgatcatg    480

gatgaacagg atcaacagct ggagatggtg tctgggagca tccaggttct gaagcacatg    540

tccggccgcg ttggagaaga gctggacgag cagggcatca tgctggatgc cttcgcccaa    600

gagatggacc acacccagtc ccgcatggac ggggtcctca ggaagttggc caaagtatcc    660

cacatgacga gtgaccgccg acagtggtgt gccatcgccg tgctagtggg ggtgcttctc    720

ctcgttctca tcttactatt ctctctctga                                     750


<210>  3717
<211>  249
<212>  PRT
<213>  Homosapiens

<400>  3717

Met Ser Leu Glu Asp Pro Phe Phe Val Val Arg Gly Glu Val Gln Lys 
1               5                   10                  15      


Ala Val Asn Thr Ala Arg Gly Leu Tyr Gln Arg Trp Cys Glu Leu Leu 
            20                  25                  30          


Gln Glu Ser Ala Ala Val Gly Arg Glu Glu Leu Asp Trp Thr Thr Asn 
        35                  40                  45              


Glu Leu Arg Asn Gly Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu 
    50                  55                  60                  


Glu Glu Thr Ile Gly Ile Val Glu Ala Asn Pro Gly Lys Phe Lys Leu 
65                  70                  75                  80  


Pro Ala Gly Asp Leu Gln Glu Arg Lys Val Phe Val Glu Arg Met Arg 
                85                  90                  95      


Glu Ala Val Gln Glu Met Lys Asp His Met Val Ser Pro Thr Ala Val 
            100                 105                 110         


Ala Phe Leu Glu Arg Asn Asn Arg Glu Ile Leu Ala Gly Lys Pro Ala 
        115                 120                 125             


Ala Gln Lys Ser Pro Ser Asp Leu Leu Asp Ala Ser Ala Val Ser Ala 
    130                 135                 140                 


Thr Ser Arg Tyr Ile Glu Glu Gln Gln Ala Thr Gln Gln Leu Ile Met 
145                 150                 155                 160 


Asp Glu Gln Asp Gln Gln Leu Glu Met Val Ser Gly Ser Ile Gln Val 
                165                 170                 175     


Leu Lys His Met Ser Gly Arg Val Gly Glu Glu Leu Asp Glu Gln Gly 
            180                 185                 190         


Ile Met Leu Asp Ala Phe Ala Gln Glu Met Asp His Thr Gln Ser Arg 
        195                 200                 205             


Met Asp Gly Val Leu Arg Lys Leu Ala Lys Val Ser His Met Thr Ser 
    210                 215                 220                 


Asp Arg Arg Gln Trp Cys Ala Ile Ala Val Leu Val Gly Val Leu Leu 
225                 230                 235                 240 


Leu Val Leu Ile Leu Leu Phe Ser Leu 
                245                 


<210>  3718
<211>  2088
<212>  DNA
<213>  Homosapiens

<400>  3718
ggtccgagtt cggaatttcg gttcaaggcc cagttcctcg gattgttcct gcgcaacttc     60

agtttccctt ccaggcacgg gcaatgagtg tttggccgcg acgagttgga aagcccggat    120

gcgtccttcg gttgggcggg gtgtctcagt gacgtcactg ggggtataaa agggcctggg    180

tggcgggcgc ctgggcagag cgtcctagca gtgtcactgc gtgggttggt ttgtgtagag    240

aggcgtgagc gagcccgttg tccggagtgc acctgctgcc tgttctgtcc ctcccgggag    300

cccccgccgc tgtcgccgtc gagtcgccat ggaagtgcag aaagaggcac agcgcatcat    360

gaccctgtcg gtgtggaaga tgtatcactc ccgcatgcag cgcggtggcc tgcggctgca    420

ccggagtctg cagctgtcgc tggtcatgcg cagcgcccgg gagctctacc tctcggccaa    480

ggtggaggcc ctcgagcccg aggtgtcgtt gccggccgcc ctcccctctg accctcgcct    540

gcacccgccc cgagaagccg agtccacggc cgagacagcg acccccgacg gtgagcaccc    600

gtttccggag ccaatggaca cgcaggaggc gccgacagcc gaggagacct ccgcctgctg    660

tgccccgcgc cccgccaaag tcagccgcaa acgacgcagc agcagcctga gcgacggcgg    720

ggacgctgga ctggtcccga gcaagaaagc ccgtctggaa gaaaaggaag aagaggaggg    780

agcgtcatcc gaagtcgccg atcgcctgca gccccctccg gcgcaagcgg agggcgcctt    840

tcccaacctg gcccgcgtcc tgcagaggcg cttctccggc ctcctgaact gcagccccgc    900

ggcccctccg acggcgccgc ccgcgtgcga ggcaaagccc gcttgccgcc cggcggacag    960

catgctcaac gtgctcgtgc gggccgtggt ggccttctga ggaccccgag cggcgctgcc   1020

ggagcccaga gcgcgcgtcg aaccgtcggc ccgagggcgc agacctgagg cgaggccacc   1080

cccctccatc ctgggggaag cgcccgcgaa aaccgtggag agaagccgcc gcccgggctg   1140

ctgagaggcc cggagaggga ctctgtcccc ggggagccat cgccttcagt gtgcagggac   1200

ggcaccgagg agtctgagcc gggggcgcgg gcgccttccg cagagacctg cgcccacagg   1260

tgctgtctta gtggactggg acgtgaacct ttcgctctcc ttctggactg ggagaaggga   1320

ggcttgggtg ttgtgttttt tgttttgttt gtttgtttgt ttttaaagat ctcctcaggg   1380

tcggacttca ttttgtactg tgggctgtgc tggccctttc aaggtttttc aagagttggt   1440

tttgcgtttc caacctcgga gaattccagg cactcccctt ccccctccgc tgacatactt   1500

gtataagcgg tcatcgttgc gtcatggggc aggcgtgggg agcttcctgt cgccttgcgt   1560

gggtgtgggg cctgggagga ggtcctgggg cgtgcacccg ccctgggcag tggggaggag   1620

agtggcctga gttacttcac ccccgcgtgc tgctggttaa tgtcccgcgt ctctgcacct   1680

tcgggtggga gcggggactg atctactttc acattctcaa gtttttctca tctgcattag   1740

aggtgcccag taggttccca ggttccagcg tgcccctccc tcagacacac ggacacaatc   1800

agccgagaag ttcctggtct gaatcacgag aatgtggagg ggtggggggt gtcagtggaa   1860

aggcataagg ctgagctgag accagttgct ggtgaaactg ggccaatctg gggaggggaa   1920

catccttgcc agggagtttc tgagggtctg ctttgtttac ctttcgtgcg gtggattctt   1980

tttaactccg tctacctggc gttttgttag aaatgtcaga taggaaaata aaaaccattt   2040

gagtaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                2088


<210>  3719
<211>  223
<212>  PRT
<213>  Homosapiens

<400>  3719

Met Glu Val Gln Lys Glu Ala Gln Arg Ile Met Thr Leu Ser Val Trp 
1               5                   10                  15      


Lys Met Tyr His Ser Arg Met Gln Arg Gly Gly Leu Arg Leu His Arg 
            20                  25                  30          


Ser Leu Gln Leu Ser Leu Val Met Arg Ser Ala Arg Glu Leu Tyr Leu 
        35                  40                  45              


Ser Ala Lys Val Glu Ala Leu Glu Pro Glu Val Ser Leu Pro Ala Ala 
    50                  55                  60                  


Leu Pro Ser Asp Pro Arg Leu His Pro Pro Arg Glu Ala Glu Ser Thr 
65                  70                  75                  80  


Ala Glu Thr Ala Thr Pro Asp Gly Glu His Pro Phe Pro Glu Pro Met 
                85                  90                  95      


Asp Thr Gln Glu Ala Pro Thr Ala Glu Glu Thr Ser Ala Cys Cys Ala 
            100                 105                 110         


Pro Arg Pro Ala Lys Val Ser Arg Lys Arg Arg Ser Ser Ser Leu Ser 
        115                 120                 125             


Asp Gly Gly Asp Ala Gly Leu Val Pro Ser Lys Lys Ala Arg Leu Glu 
    130                 135                 140                 


Glu Lys Glu Glu Glu Glu Gly Ala Ser Ser Glu Val Ala Asp Arg Leu 
145                 150                 155                 160 


Gln Pro Pro Pro Ala Gln Ala Glu Gly Ala Phe Pro Asn Leu Ala Arg 
                165                 170                 175     


Val Leu Gln Arg Arg Phe Ser Gly Leu Leu Asn Cys Ser Pro Ala Ala 
            180                 185                 190         


Pro Pro Thr Ala Pro Pro Ala Cys Glu Ala Lys Pro Ala Cys Arg Pro 
        195                 200                 205             


Ala Asp Ser Met Leu Asn Val Leu Val Arg Ala Val Val Ala Phe 
    210                 215                 220             


<210>  3720
<211>  7807
<212>  DNA
<213>  Homosapiens

<400>  3720
cgcaccctcc ttccgcccct ccttctccgg ggtcagccag gaagatgtcc cgagctgcta     60

tccccggctc ggcccgggca gccgccttct gagcccccga cccgaggcgc cgagccgccg    120

ccgcccgatg ggctgggccg tggagcgtct ccgcagtcgt agctccagcc gccgcgctcc    180

cagccccggc agcctcagca tcagcggcgg cggcggcggc ggcggcggcg tcttccgcat    240

cgttcgccgc agcgtaaccc ggagcccttt gctctttgca gaatggcccg cttcggagac    300

gagatgccgg cccgctacgg gggaggaggc tccggggcag ccgccggggt ggtcgtgggc    360

agcggaggcg ggcgaggagc cgggggcagc cggcagggcg ggcagcccgg ggcgcaaagg    420

atgtacaagc agtcaatggc gcagagagcg cggaccatgg cactctacaa ccccatcccc    480

gtccgacaga actgcctcac ggttaaccgg tctctcttcc tcttcagcga agacaacgtg    540

gtgagaaaat acgccaaaaa gatcaccgaa tggcctccct ttgaatatat gattttagcc    600

accatcatag cgaattgcat cgtcctcgca ctggagcagc atctgcctga tgatgacaag    660

accccgatgt ctgaacggct ggatgacaca gaaccatact tcattggaat tttttgtttc    720

gaggctggaa ttaaaatcat tgcccttggg tttgccttcc acaaaggctc ctacttgagg    780

aatggctgga atgtcatgga ctttgtggtg gtgctaacgg gcatcttggc gacagttggg    840

acggagtttg acctacggac gctgagggca gttcgagtgc tgcggccgct caagctggtg    900

tctggaatcc caagtttaca agtcgtcctg aagtcgatca tgaaggcgat gatccctttg    960

ctgcagatcg gcctcctcct attttttgca atccttattt ttgcaatcat agggttagaa   1020

ttttatatgg gaaaatttca taccacctgc tttgaagagg ggacagatga cattcagggt   1080

gagtctccgg ctccatgtgg gacagaagag cccgcccgca cctgccccaa tgggaccaaa   1140

tgtcagccct actgggaagg gcccaacaac gggatcactc agttcgacaa catcctgttt   1200

gcagtgctga ctgttttcca gtgcataacc atggaagggt ggactgatct cctctacaat   1260

agcaacgatg cctcagggaa cacttggaac tggttgtact tcatccccct catcatcatc   1320

ggctcctttt ttatgctgaa ccttgtgctg ggtgtgctgt caggggagtt tgccaaagaa   1380

agggaacggg tggagaaccg gcgggctttt ctgaagctga ggcggcaaca acagattgaa   1440

cgtgagctca atgggtacat ggaatggatc tcaaaagcag aagaggtgat cctcgccgag   1500

gatgaaactg acggggagca gaggcatccc tttgatggag ctctgcggag aaccaccata   1560

aagaaaagca agacagattt gctcaacccc gaagaggctg aggatcagct ggctgatata   1620

gcctctgtgg gttctccctt cgcccgagcc agcattaaaa gtgccaagct ggagaactcg   1680

accttttttc acaaaaagga gaggaggatg cgtttctaca tccgccgcat ggtcaaaact   1740

caggccttct actggactgt actcagtttg gtagctctca acacgctgtg tgttgctatt   1800

gttcactaca accagcccga gtggctctcc gacttccttt actatgcaga attcattttc   1860

ttaggactct ttatgtccga aatgtttata aaaatgtacg ggcttgggac gcggccttac   1920

ttccactctt ccttcaactg ctttgactgt ggggttatca ttgggagcat cttcgaggtc   1980

atctgggctg tcataaaacc tggcacatcc tttggaatca gcgtgttacg agccctcagg   2040

ttattgcgta ttttcaaagt cacaaagtac tgggcatctc tcagaaacct ggtcgtctct   2100

ctcctcaact ccatgaagtc catcatcagc ctgttgtttc tccttttcct gttcattgtc   2160

gtcttcgccc ttttgggaat gcaactcttc ggcggccagt ttaatttcga tgaagggact   2220

cctcccacca acttcgatac ttttccagca gcaataatga cggtgtttca gatcctgacg   2280

ggcgaagact ggaacgaggt catgtacgac gggatcaagt ctcagggggg cgtgcagggc   2340

ggcatggtgt tctccatcta tttcattgta ctgacgctct ttgggaacta caccctcctg   2400

aatgtgttct tggccatcgc tgtggacaat ctggccaacg cccaggagct caccaaggac   2460

gagcaagagg aagaagaagc agcgaaccag aaacttgccc tacagaaagc caaggaggtg   2520

gcagaagtga gtcctctgtc cgcggccaac atgtctatag ctgtgaaaga gcaacagaag   2580

aatcaaaagc cagccaagtc cgtgtgggag cagcggacca gtgagatgcg aaagcagaac   2640

ttgctggcca gccgggaggc cctgtataac gaaatggacc cggacgagcg ctggaaggct   2700

gcctacacgc ggcacctgcg gccagacatg aagacgcact tggaccggcc gctggtggtg   2760

gacccgcagg agaaccgcaa caacaacacc aacaagagcc gggcggccga gcccaccgtg   2820

gaccagcgcc tcggccagca gcgcgccgag gacttcctca ggaaacaggc ccgctaccac   2880

gatcgggccc gggaccccag cggctcggcg ggcctggacg cacggaggcc ctgggcggga   2940

agccaggagg ccgagctgag ccgggaggga ccctacggcc gcgagtcgga ccaccacgcc   3000

cgggagggca gcctggagca acccgggttc tgggagggcg aggccgagcg aggcaaggcc   3060

ggggaccccc accggaggca cgtgcaccgg caggggggca gcagggagag ccgcagcggg   3120

tccccgcgca cgggcgcgga cggggagcat cgacgtcatc gcgcgcaccg caggcccggg   3180

gaggagggtc cggaggacaa ggcggagcgg agggcgcggc accgcgaggg cagccggccg   3240

gcccggggcg gcgagggcga gggcgagggc cccgacgggg gcgagcgcag gagaaggcac   3300

cggcatggcg ctccagccac gtacgagggg gacgcgcgga gggaggacaa ggagcggagg   3360

catcggagga ggaaagagaa ccagggctcc ggggtccctg tgtcgggccc caacctgtca   3420

accacccggc caatccagca ggacctgggc cgccaagacc cacccctggc agaggatatt   3480

gacaacatga agaacaacaa gctggccacc gcggagtcgg ccgctcccca cggcagcctt   3540

ggccacgccg gcctgcccca gagcccagcc aagatgggaa acagcaccga ccccggcccc   3600

atgctggcca tccctgccat ggccaccaac ccccagaacg ccgccagccg ccggacgccc   3660

aacaacccgg ggaacccatc caatcccggc ccccccaaga cccccgagaa tagccttatc   3720

gtcaccaacc ccagcggcac ccagaccaat tcagctaaga ctgccaggaa acccgaccac   3780

accacagtgg acatcccccc agcctgccca ccccccctca accacaccgt cgtacaagtg   3840

aacaaaaacg ccaacccaga cccactgcca aaaaaagagg aagagaagaa ggaggaggag   3900

gaagacgacc gtggggaaga cggccctaag ccaatgcctc cctatagctc catgttcatc   3960

ctgtccacga ccaaccccct tcgccgcctg tgccattaca tcctgaacct gcgctacttt   4020

gagatgtgca tcctcatggt cattgccatg agcagcatcg ccctggccgc cgaggaccct   4080

gtgcagccca acgcacctcg gaacaacgtg ctgcgatact ttgactacgt ttttacaggc   4140

gtctttacct ttgagatggt gatcaagatg attgacctgg ggctcgtcct gcatcagggt   4200

gcctacttcc gtgacctctg gaatattctc gacttcatag tggtcagtgg ggccctggta   4260

gcctttgcct tcactggcaa tagcaaagga aaagacatca acacgattaa atccctccga   4320

gtcctccggg tgctacgacc tcttaaaacc atcaagcggc tgccaaagct caaggctgtg   4380

tttgactgtg tggtgaactc acttaaaaac gtcttcaaca tcctcatcgt ctacatgcta   4440

ttcatgttca tcttcgccgt ggtggctgtg cagctcttca aggggaaatt cttccactgc   4500

actgacgagt ccaaagagtt tgagaaagat tgtcgaggca aatacctcct ctacgagaag   4560

aatgaggtga aggcgcgaga ccgggagtgg aagaagtatg aattccatta cgacaatgtg   4620

ctgtgggctc tgctgaccct cttcaccgtg tccacgggag aaggctggcc acaggtcctc   4680

aagcattcgg tggacgccac ctttgagaac cagggcccca gccccgggta ccgcatggag   4740

atgtccattt tctacgtcgt ctactttgtg gtgttcccct tcttctttgt caatatcttt   4800

gtggccttga tcatcatcac cttccaggag caaggggaca agatgatgga ggaatacagc   4860

ctggagaaaa atgagagggc ctgcattgat ttcgccatca gcgccaagcc gctgacccga   4920

cacatgccgc agaacaagca gagcttccag taccgcatgt ggcagttcgt ggtgtctccg   4980

cctttcgagt acacgatcat ggccatgatc gccctcaaca ccatcgtgct tatgatgaag   5040

ttctatgggg cttctgttgc ttatgaaaat gccctgcggg tgttcaacat cgtcttcacc   5100

tccctcttct ctctggaatg tgtgctgaaa gtcatggctt ttgggattct gaattatttc   5160

cgcgatgcct ggaacatctt cgactttgtg actgttctgg gcagcatcac cgatatcctc   5220

gtgactgagt ttgggaataa cttcatcaac ctgagctttc tccgcctctt ccgagctgcc   5280

cggctcatca aacttctccg tcagggttac accatccgca ttcttctctg gacctttgtg   5340

cagtccttca aggccctgcc ttatgtctgt ctgctgatcg ccatgctctt cttcatctat   5400

gccatcattg ggatgcaggt gtttggtaac attggcatcg acgtggagga cgaggacagt   5460

gatgaagatg agttccaaat cactgagcac aataacttcc ggaccttctt ccaggccctc   5520

atgcttctct tccggagtgc caccggggaa gcttggcaca acatcatgct ttcctgcctc   5580

agcgggaaac cgtgtgataa gaactctggc atcctgactc gagagtgtgg caatgaattt   5640

gcttattttt actttgtttc cttcatcttc ctctgctcgt ttctgatgct gaatctcttt   5700

gtcgccgtca tcatggacaa ctttgagtac ctcacccgag actcctccat cctgggcccc   5760

caccacctgg atgagtacgt gcgtgtctgg gccgagtatg accccgcagc ttgcggtcgg   5820

attcattata aggatatgta cagtttatta cgagtaatat ctccccctct cggcttaggc   5880

aagaaatgtc ctcatagggt tgcttgcaag cggcttctgc ggatggacct gcccgtcgca   5940

gatgacaaca ccgtccactt caattccacc ctcatggctc tgatccgcac agccctggac   6000

atcaagattg ccaagggagg agccgacaaa cagcagatgg acgctgagct gcggaaggag   6060

atgatggcga tttggcccaa tctgtcccag aagacgctag acctgctggt cacacctcac   6120

aagtccacgg acctcaccgt ggggaagatc tacgcagcca tgatgatcat ggagtactac   6180

cggcagagca aggccaagaa gctgcaggcc atgcgcgagg agcaggaccg gacacccctc   6240

atgttccagc gcatggagcc cccgtcccca acgcaggaag ggggacctgg ccagaacgcc   6300

ctcccctcca cccagctgga cccaggagga gccctgatgg ctcacgaaag cggcctcaag   6360

gagagcccgt cctgggtgac ccagcgtgcc caggagatgt tccagaagac gggcacatgg   6420

agtccggaac aaggcccccc taccgacatg cccaacagcc agcctaactc tcagtccgtg   6480

gagatgcgag agatgggcag agatggctac tccgacagcg agcactacct ccccatggaa   6540

ggccagggcc gggctgcctc catgccccgc ctccctgcag agaaccagag gagaaggggc   6600

cggccacgtg ggaataacct cagtaccatc tcagacacca gccccatgaa gcgttcagcc   6660

tccgtgctgg gccccaaggc ccgacgcctg gacgattact cgctggagcg ggtcccgccc   6720

gaggagaacc agcggcacca ccagcggcgc cgcgaccgca gccaccgcgc ctctgagcgc   6780

tccctgggcc gctacaccga tgtggacaca ggcttgggga cagacctgag catgaccacc   6840

caatccgggg acctgccgtc gaaggagcgg gaccaggagc ggggccggcc caaggatcgg   6900

aagcatcgac agcaccacca ccaccaccac caccaccacc atcccccgcc ccccgacaag   6960

gaccgctatg cccaggaacg gccggaccac ggccgggcac gggctcggga ccagcgctgg   7020

tcccgctcgc ccagcgaggg ccgagagcac atggcgcacc ggcagtagtt ccgtaagtgg   7080

aagcccagcc ccctcaacat ctggtaccag cactccgcgg cggggccgcc gccagctccc   7140

ccagaccccc tccacccccc ggccacacgt gtcctattcc cctgtgatcc gtaaggccgg   7200

cggctcgggg cccccgcagc agcagcagca gcagcagcag cagcagcagg cggtggccag   7260

gccgggccgg gcggccacca gcggccctcg gaggtaccca ggccccacgg ccgagcctct   7320

ggccggagat cggccgccca cggggggcca cagcagcggc cgctcgccca ggatggagag   7380

gcgggtccca ggcccggccc ggagcgagtc ccccagggcc tgtcgacacg gcggggcccg   7440

gtggccggca tctggcccgc acgtgtccga ggggcccccg ggtccccggc accatggcta   7500

ctaccggggc tccgactacg acgaggccga tggcccgggc agcgggggcg gcgaggaggc   7560

catggccggg gcctacgacg cgccaccccc cgtacgacac gcgtcctcgg gcgccaccgg   7620

gcgctcgccc aggactcccc gggcctcggg cccggcctgc gcctcgcctt ctcggcacgg   7680

ccggcgactc cccaacggct actacccggc gcacggactg gccaggcccc gcgggccggg   7740

ctccaggaag ggcctgcacg aaccctacag cgagagtgac gatgattggt gctaagcccg   7800

ggcgagg                                                             7807


<210>  3721
<211>  2261
<212>  PRT
<213>  Homosapiens

<400>  3721

Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu Arg 
            180                 185                 190         


Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr Cys 
                245                 250                 255     


Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp 
305                 310                 315                 320 


Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln 
                725                 730                 735     


Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu 
            740                 745                 750         


Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln 
        755                 760                 765             


Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu Met Arg Lys 
    770                 775                 780                 


Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro 
785                 790                 795                 800 


Asp Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg Pro Asp Met 
                805                 810                 815     


Lys Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg 
            820                 825                 830         


Asn Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr Val Asp Gln 
        835                 840                 845             


Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg 
    850                 855                 860                 


Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala 
865                 870                 875                 880 


Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly 
                885                 890                 895     


Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu 
            900                 905                 910         


Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp 
        915                 920                 925             


Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg 
    930                 935                 940                 


Ser Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg Arg His Arg 
945                 950                 955                 960 


Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg 
                965                 970                 975     


Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly 
            980                 985                 990         


Glu Gly Glu Gly Pro Asp Gly Gly  Glu Arg Arg Arg Arg  His Arg His 
        995                 1000                 1005             


Gly Ala  Pro Ala Thr Tyr Glu  Gly Asp Ala Arg Arg  Glu Asp Lys 
    1010                 1015                 1020             


Glu Arg  Arg His Arg Arg Arg  Lys Glu Asn Gln Gly  Ser Gly Val 
    1025                 1030                 1035             


Pro Val  Ser Gly Pro Asn Leu  Ser Thr Thr Arg Pro  Ile Gln Gln 
    1040                 1045                 1050             


Asp Leu  Gly Arg Gln Asp Pro  Pro Leu Ala Glu Asp  Ile Asp Asn 
    1055                 1060                 1065             


Met Lys  Asn Asn Lys Leu Ala  Thr Ala Glu Ser Ala  Ala Pro His 
    1070                 1075                 1080             


Gly Ser  Leu Gly His Ala Gly  Leu Pro Gln Ser Pro  Ala Lys Met 
    1085                 1090                 1095             


Gly Asn  Ser Thr Asp Pro Gly  Pro Met Leu Ala Ile  Pro Ala Met 
    1100                 1105                 1110             


Ala Thr  Asn Pro Gln Asn Ala  Ala Ser Arg Arg Thr  Pro Asn Asn 
    1115                 1120                 1125             


Pro Gly  Asn Pro Ser Asn Pro  Gly Pro Pro Lys Thr  Pro Glu Asn 
    1130                 1135                 1140             


Ser Leu  Ile Val Thr Asn Pro  Ser Gly Thr Gln Thr  Asn Ser Ala 
    1145                 1150                 1155             


Lys Thr  Ala Arg Lys Pro Asp  His Thr Thr Val Asp  Ile Pro Pro 
    1160                 1165                 1170             


Ala Cys  Pro Pro Pro Leu Asn  His Thr Val Val Gln  Val Asn Lys 
    1175                 1180                 1185             


Asn Ala  Asn Pro Asp Pro Leu  Pro Lys Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Glu Asp Asp Arg  Gly Glu Asp Gly Pro  Lys Pro Met 
    1205                 1210                 1215             


Pro Pro  Tyr Ser Ser Met Phe  Ile Leu Ser Thr Thr  Asn Pro Leu 
    1220                 1225                 1230             


Arg Arg  Leu Cys His Tyr Ile  Leu Asn Leu Arg Tyr  Phe Glu Met 
    1235                 1240                 1245             


Cys Ile  Leu Met Val Ile Ala  Met Ser Ser Ile Ala  Leu Ala Ala 
    1250                 1255                 1260             


Glu Asp  Pro Val Gln Pro Asn  Ala Pro Arg Asn Asn  Val Leu Arg 
    1265                 1270                 1275             


Tyr Phe  Asp Tyr Val Phe Thr  Gly Val Phe Thr Phe  Glu Met Val 
    1280                 1285                 1290             


Ile Lys  Met Ile Asp Leu Gly  Leu Val Leu His Gln  Gly Ala Tyr 
    1295                 1300                 1305             


Phe Arg  Asp Leu Trp Asn Ile  Leu Asp Phe Ile Val  Val Ser Gly 
    1310                 1315                 1320             


Ala Leu  Val Ala Phe Ala Phe  Thr Gly Asn Ser Lys  Gly Lys Asp 
    1325                 1330                 1335             


Ile Asn  Thr Ile Lys Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro 
    1340                 1345                 1350             


Leu Lys  Thr Ile Lys Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp 
    1355                 1360                 1365             


Cys Val  Val Asn Ser Leu Lys  Asn Val Phe Asn Ile  Leu Ile Val 
    1370                 1375                 1380             


Tyr Met  Leu Phe Met Phe Ile  Phe Ala Val Val Ala  Val Gln Leu 
    1385                 1390                 1395             


Phe Lys  Gly Lys Phe Phe His  Cys Thr Asp Glu Ser  Lys Glu Phe 
    1400                 1405                 1410             


Glu Lys  Asp Cys Arg Gly Lys  Tyr Leu Leu Tyr Glu  Lys Asn Glu 
    1415                 1420                 1425             


Val Lys  Ala Arg Asp Arg Glu  Trp Lys Lys Tyr Glu  Phe His Tyr 
    1430                 1435                 1440             


Asp Asn  Val Leu Trp Ala Leu  Leu Thr Leu Phe Thr  Val Ser Thr 
    1445                 1450                 1455             


Gly Glu  Gly Trp Pro Gln Val  Leu Lys His Ser Val  Asp Ala Thr 
    1460                 1465                 1470             


Phe Glu  Asn Gln Gly Pro Ser  Pro Gly Tyr Arg Met  Glu Met Ser 
    1475                 1480                 1485             


Ile Phe  Tyr Val Val Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val 
    1490                 1495                 1500             


Asn Ile  Phe Val Ala Leu Ile  Ile Ile Thr Phe Gln  Glu Gln Gly 
    1505                 1510                 1515             


Asp Lys  Met Met Glu Glu Tyr  Ser Leu Glu Lys Asn  Glu Arg Ala 
    1520                 1525                 1530             


Cys Ile  Asp Phe Ala Ile Ser  Ala Lys Pro Leu Thr  Arg His Met 
    1535                 1540                 1545             


Pro Gln  Asn Lys Gln Ser Phe  Gln Tyr Arg Met Trp  Gln Phe Val 
    1550                 1555                 1560             


Val Ser  Pro Pro Phe Glu Tyr  Thr Ile Met Ala Met  Ile Ala Leu 
    1565                 1570                 1575             


Asn Thr  Ile Val Leu Met Met  Lys Phe Tyr Gly Ala  Ser Val Ala 
    1580                 1585                 1590             


Tyr Glu  Asn Ala Leu Arg Val  Phe Asn Ile Val Phe  Thr Ser Leu 
    1595                 1600                 1605             


Phe Ser  Leu Glu Cys Val Leu  Lys Val Met Ala Phe  Gly Ile Leu 
    1610                 1615                 1620             


Asn Tyr  Phe Arg Asp Ala Trp  Asn Ile Phe Asp Phe  Val Thr Val 
    1625                 1630                 1635             


Leu Gly  Ser Ile Thr Asp Ile  Leu Val Thr Glu Phe  Gly Asn Asn 
    1640                 1645                 1650             


Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe Arg Ala  Ala Arg Leu 
    1655                 1660                 1665             


Ile Lys  Leu Leu Arg Gln Gly  Tyr Thr Ile Arg Ile  Leu Leu Trp 
    1670                 1675                 1680             


Thr Phe  Val Gln Ser Phe Lys  Ala Leu Pro Tyr Val  Cys Leu Leu 
    1685                 1690                 1695             


Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile Ile Gly  Met Gln Val 
    1700                 1705                 1710             


Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp Glu Asp  Ser Asp Glu 
    1715                 1720                 1725             


Asp Glu  Phe Gln Ile Thr Glu  His Asn Asn Phe Arg  Thr Phe Phe 
    1730                 1735                 1740             


Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala Thr Gly  Glu Ala Trp 
    1745                 1750                 1755             


His Asn  Ile Met Leu Ser Cys  Leu Ser Gly Lys Pro  Cys Asp Lys 
    1760                 1765                 1770             


Asn Ser  Gly Ile Leu Thr Arg  Glu Cys Gly Asn Glu  Phe Ala Tyr 
    1775                 1780                 1785             


Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys Ser Phe  Leu Met Leu 
    1790                 1795                 1800             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Glu  Tyr Leu Thr 
    1805                 1810                 1815             


Arg Asp  Ser Ser Ile Leu Gly  Pro His His Leu Asp  Glu Tyr Val 
    1820                 1825                 1830             


Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala Cys Gly  Arg Ile His 
    1835                 1840                 1845             


Tyr Lys  Asp Met Tyr Ser Leu  Leu Arg Val Ile Ser  Pro Pro Leu 
    1850                 1855                 1860             


Gly Leu  Gly Lys Lys Cys Pro  His Arg Val Ala Cys  Lys Arg Leu 
    1865                 1870                 1875             


Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp Asn Thr  Val His Phe 
    1880                 1885                 1890             


Asn Ser  Thr Leu Met Ala Leu  Ile Arg Thr Ala Leu  Asp Ile Lys 
    1895                 1900                 1905             


Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln Met Asp  Ala Glu Leu 
    1910                 1915                 1920             


Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn Leu Ser  Gln Lys Thr 
    1925                 1930                 1935             


Leu Asp  Leu Leu Val Thr Pro  His Lys Ser Thr Asp  Leu Thr Val 
    1940                 1945                 1950             


Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met Glu Tyr  Tyr Arg Gln 
    1955                 1960                 1965             


Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg Glu Glu  Gln Asp Arg 
    1970                 1975                 1980             


Thr Pro  Leu Met Phe Gln Arg  Met Glu Pro Pro Ser  Pro Thr Gln 
    1985                 1990                 1995             


Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro Ser Thr  Gln Leu Asp 
    2000                 2005                 2010             


Pro Gly  Gly Ala Leu Met Ala  His Glu Ser Gly Leu  Lys Glu Ser 
    2015                 2020                 2025             


Pro Ser  Trp Val Thr Gln Arg  Ala Gln Glu Met Phe  Gln Lys Thr 
    2030                 2035                 2040             


Gly Thr  Trp Ser Pro Glu Gln  Gly Pro Pro Thr Asp  Met Pro Asn 
    2045                 2050                 2055             


Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met Arg Glu  Met Gly Arg 
    2060                 2065                 2070             


Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu Pro Met  Glu Gly Gln 
    2075                 2080                 2085             


Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro Ala Glu  Asn Gln Arg 
    2090                 2095                 2100             


Arg Arg  Gly Arg Pro Arg Gly  Asn Asn Leu Ser Thr  Ile Ser Asp 
    2105                 2110                 2115             


Thr Ser  Pro Met Lys Arg Ser  Ala Ser Val Leu Gly  Pro Lys Ala 
    2120                 2125                 2130             


Arg Arg  Leu Asp Asp Tyr Ser  Leu Glu Arg Val Pro  Pro Glu Glu 
    2135                 2140                 2145             


Asn Gln  Arg His His Gln Arg  Arg Arg Asp Arg Ser  His Arg Ala 
    2150                 2155                 2160             


Ser Glu  Arg Ser Leu Gly Arg  Tyr Thr Asp Val Asp  Thr Gly Leu 
    2165                 2170                 2175             


Gly Thr  Asp Leu Ser Met Thr  Thr Gln Ser Gly Asp  Leu Pro Ser 
    2180                 2185                 2190             


Lys Glu  Arg Asp Gln Glu Arg  Gly Arg Pro Lys Asp  Arg Lys His 
    2195                 2200                 2205             


Arg Gln  His His His His His  His His His His His  Pro Pro Pro 
    2210                 2215                 2220             


Pro Asp  Lys Asp Arg Tyr Ala  Gln Glu Arg Pro Asp  His Gly Arg 
    2225                 2230                 2235             


Ala Arg  Ala Arg Asp Gln Arg  Trp Ser Arg Ser Pro  Ser Glu Gly 
    2240                 2245                 2250             


Arg Glu  His Met Ala His Arg  Gln 
    2255                 2260     


<210>  3722
<211>  7812
<212>  DNA
<213>  Homosapiens

<400>  3722
cgcaccctcc ttccgcccct ccttctccgg ggtcagccag gaagatgtcc cgagctgcta     60

tccccggctc ggcccgggca gccgccttct gagcccccga cccgaggcgc cgagccgccg    120

ccgcccgatg ggctgggccg tggagcgtct ccgcagtcgt agctccagcc gccgcgctcc    180

cagccccggc agcctcagca tcagcggcgg cggcggcggc ggcggcggcg tcttccgcat    240

cgttcgccgc agcgtaaccc ggagcccttt gctctttgca gaatggcccg cttcggagac    300

gagatgccgg cccgctacgg gggaggaggc tccggggcag ccgccggggt ggtcgtgggc    360

agcggaggcg ggcgaggagc cgggggcagc cggcagggcg ggcagcccgg ggcgcaaagg    420

atgtacaagc agtcaatggc gcagagagcg cggaccatgg cactctacaa ccccatcccc    480

gtccgacaga actgcctcac ggttaaccgg tctctcttcc tcttcagcga agacaacgtg    540

gtgagaaaat acgccaaaaa gatcaccgaa tggcctccct ttgaatatat gattttagcc    600

accatcatag cgaattgcat cgtcctcgca ctggagcagc atctgcctga tgatgacaag    660

accccgatgt ctgaacggct ggatgacaca gaaccatact tcattggaat tttttgtttc    720

gaggctggaa ttaaaatcat tgcccttggg tttgccttcc acaaaggctc ctacttgagg    780

aatggctgga atgtcatgga ctttgtggtg gtgctaacgg gcatcttggc gacagttggg    840

acggagtttg acctacggac gctgagggca gttcgagtgc tgcggccgct caagctggtg    900

tctggaatcc caagtttaca agtcgtcctg aagtcgatca tgaaggcgat gatccctttg    960

ctgcagatcg gcctcctcct attttttgca atccttattt ttgcaatcat agggttagaa   1020

ttttatatgg gaaaatttca taccacctgc tttgaagagg ggacagatga cattcagggt   1080

gagtctccgg ctccatgtgg gacagaagag cccgcccgca cctgccccaa tgggaccaaa   1140

tgtcagccct actgggaagg gcccaacaac gggatcactc agttcgacaa catcctgttt   1200

gcagtgctga ctgttttcca gtgcataacc atggaagggt ggactgatct cctctacaat   1260

agcaacgatg cctcagggaa cacttggaac tggttgtact tcatccccct catcatcatc   1320

ggctcctttt ttatgctgaa ccttgtgctg ggtgtgctgt caggggagtt tgccaaagaa   1380

agggaacggg tggagaaccg gcgggctttt ctgaagctga ggcggcaaca acagattgaa   1440

cgtgagctca atgggtacat ggaatggatc tcaaaagcag aagaggtgat cctcgccgag   1500

gatgaaactg acggggagca gaggcatccc tttgatggag ctctgcggag aaccaccata   1560

aagaaaagca agacagattt gctcaacccc gaagaggctg aggatcagct ggctgatata   1620

gcctctgtgg gttctccctt cgcccgagcc agcattaaaa gtgccaagct ggagaactcg   1680

accttttttc acaaaaagga gaggaggatg cgtttctaca tccgccgcat ggtcaaaact   1740

caggccttct actggactgt actcagtttg gtagctctca acacgctgtg tgttgctatt   1800

gttcactaca accagcccga gtggctctcc gacttccttt actatgcaga attcattttc   1860

ttaggactct ttatgtccga aatgtttata aaaatgtacg ggcttgggac gcggccttac   1920

ttccactctt ccttcaactg ctttgactgt ggggttatca ttgggagcat cttcgaggtc   1980

atctgggctg tcataaaacc tggcacatcc tttggaatca gcgtgttacg agccctcagg   2040

ttattgcgta ttttcaaagt cacaaagtac tgggcatctc tcagaaacct ggtcgtctct   2100

ctcctcaact ccatgaagtc catcatcagc ctgttgtttc tccttttcct gttcattgtc   2160

gtcttcgccc ttttgggaat gcaactcttc ggcggccagt ttaatttcga tgaagggact   2220

cctcccacca acttcgatac ttttccagca gcaataatga cggtgtttca gatcctgacg   2280

ggcgaagact ggaacgaggt catgtacgac gggatcaagt ctcagggggg cgtgcagggc   2340

ggcatggtgt tctccatcta tttcattgta ctgacgctct ttgggaacta caccctcctg   2400

aatgtgttct tggccatcgc tgtggacaat ctggccaacg cccaggagct caccaaggac   2460

gagcaagagg aagaagaagc agcgaaccag aaacttgccc tacagaaagc caaggaggtg   2520

gcagaagtga gtcctctgtc cgcggccaac atgtctatag ctgtgaaaga gcaacagaag   2580

aatcaaaagc cagccaagtc cgtgtgggag cagcggacca gtgagatgcg aaagcagaac   2640

ttgctggcca gccgggaggc cctgtataac gaaatggacc cggacgagcg ctggaaggct   2700

gcctacacgc ggcacctgcg gccagacatg aagacgcact tggaccggcc gctggtggtg   2760

gacccgcagg agaaccgcaa caacaacacc aacaagagcc gggcggccga gcccaccgtg   2820

gaccagcgcc tcggccagca gcgcgccgag gacttcctca ggaaacaggc ccgctaccac   2880

gatcgggccc gggaccccag cggctcggcg ggcctggacg cacggaggcc ctgggcggga   2940

agccaggagg ccgagctgag ccgggaggga ccctacggcc gcgagtcgga ccaccacgcc   3000

cgggagggca gcctggagca acccgggttc tgggagggcg aggccgagcg aggcaaggcc   3060

ggggaccccc accggaggca cgtgcaccgg caggggggca gcagggagag ccgcagcggg   3120

tccccgcgca cgggcgcgga cggggagcat cgacgtcatc gcgcgcaccg caggcccggg   3180

gaggagggtc cggaggacaa ggcggagcgg agggcgcggc accgcgaggg cagccggccg   3240

gcccggggcg gcgagggcga gggcgagggc cccgacgggg gcgagcgcag gagaaggcac   3300

cggcatggcg ctccagccac gtacgagggg gacgcgcgga gggaggacaa ggagcggagg   3360

catcggagga ggaaagagaa ccagggctcc ggggtccctg tgtcgggccc caacctgtca   3420

accacccggc caatccagca ggacctgggc cgccaagacc cacccctggc agaggatatt   3480

gacaacatga agaacaacaa gctggccacc gcggagtcgg ccgctcccca cggcagcctt   3540

ggccacgccg gcctgcccca gagcccagcc aagatgggaa acagcaccga ccccggcccc   3600

atgctggcca tccctgccat ggccaccaac ccccagaacg ccgccagccg ccggacgccc   3660

aacaacccgg ggaacccatc caatcccggc ccccccaaga cccccgagaa tagccttatc   3720

gtcaccaacc ccagcggcac ccagaccaat tcagctaaga ctgccaggaa acccgaccac   3780

accacagtgg acatcccccc agcctgccca ccccccctca accacaccgt cgtacaagtg   3840

aacaaaaacg ccaacccaga cccactgcca aaaaaagagg aagagaagaa ggaggaggag   3900

gaagacgacc gtggggaaga cggccctaag ccaatgcctc cctatagctc catgttcatc   3960

ctgtccacga ccaaccccct tcgccgcctg tgccattaca tcctgaacct gcgctacttt   4020

gagatgtgca tcctcatggt cattgccatg agcagcatcg ccctggccgc cgaggaccct   4080

gtgcagccca acgcacctcg gaacaacgtg ctgcgatact ttgactacgt ttttacaggc   4140

gtctttacct ttgagatggt gatcaagatg attgacctgg ggctcgtcct gcatcagggt   4200

gcctacttcc gtgacctctg gaatattctc gacttcatag tggtcagtgg ggccctggta   4260

gcctttgcct tcactggcaa tagcaaagga aaagacatca acacgattaa atccctccga   4320

gtcctccggg tgctacgacc tcttaaaacc atcaagcggc tgccaaagct caaggctgtg   4380

tttgactgtg tggtgaactc acttaaaaac gtcttcaaca tcctcatcgt ctacatgcta   4440

ttcatgttca tcttcgccgt ggtggctgtg cagctcttca aggggaaatt cttccactgc   4500

actgacgagt ccaaagagtt tgagaaagat tgtcgaggca aatacctcct ctacgagaag   4560

aatgaggtga aggcgcgaga ccgggagtgg aagaagtatg aattccatta cgacaatgtg   4620

ctgtgggctc tgctgaccct cttcaccgtg tccacgggag aaggctggcc acaggtcctc   4680

aagcattcgg tggacgccac ctttgagaac cagggcccca gccccgggta ccgcatggag   4740

atgtccattt tctacgtcgt ctactttgtg gtgttcccct tcttctttgt caatatcttt   4800

gtggccttga tcatcatcac cttccaggag caaggggaca agatgatgga ggaatacagc   4860

ctggagaaaa atgagagggc ctgcattgat ttcgccatca gcgccaagcc gctgacccga   4920

cacatgccgc agaacaagca gagcttccag taccgcatgt ggcagttcgt ggtgtctccg   4980

cctttcgagt acacgatcat ggccatgatc gccctcaaca ccatcgtgct tatgatgaag   5040

ttctatgggg cttctgttgc ttatgaaaat gccctgcggg tgttcaacat cgtcttcacc   5100

tccctcttct ctctggaatg tgtgctgaaa gtcatggctt ttgggattct gaattatttc   5160

cgcgatgcct ggaacatctt cgactttgtg actgttctgg gcagcatcac cgatatcctc   5220

gtgactgagt ttgggaataa cttcatcaac ctgagctttc tccgcctctt ccgagctgcc   5280

cggctcatca aacttctccg tcagggttac accatccgca ttcttctctg gacctttgtg   5340

cagtccttca aggccctgcc ttatgtctgt ctgctgatcg ccatgctctt cttcatctat   5400

gccatcattg ggatgcaggt gtttggtaac attggcatcg acgtggagga cgaggacagt   5460

gatgaagatg agttccaaat cactgagcac aataacttcc ggaccttctt ccaggccctc   5520

atgcttctct tccggagtgc caccggggaa gcttggcaca acatcatgct ttcctgcctc   5580

agcgggaaac cgtgtgataa gaactctggc atcctgactc gagagtgtgg caatgaattt   5640

gcttattttt actttgtttc cttcatcttc ctctgctcgt ttctgatgct gaatctcttt   5700

gtcgccgtca tcatggacaa ctttgagtac ctcacccgag actcctccat cctgggcccc   5760

caccacctgg atgagtacgt gcgtgtctgg gccgagtatg accccgcagc ttgcggtcgg   5820

attcattata aggatatgta cagtttatta cgagtaatat ctccccctct cggcttaggc   5880

aagaaatgtc ctcatagggt tgcttgcaag cggcttctgc ggatggacct gcccgtcgca   5940

gatgacaaca ccgtccactt caattccacc ctcatggctc tgatccgcac agccctggac   6000

atcaagattg ccaagggagg agccgacaaa cagcagatgg acgctgagct gcggaaggag   6060

atgatggcga tttggcccaa tctgtcccag aagacgctag acctgctggt cacacctcac   6120

aagtccacgg acctcaccgt ggggaagatc tacgcagcca tgatgatcat ggagtactac   6180

cggcagagca aggccaagaa gctgcaggcc atgcgcgagg agcaggaccg gacacccctc   6240

atgttccagc gcatggagcc cccgtcccca acgcaggaag ggggacctgg ccagaacgcc   6300

ctcccctcca cccagctgga cccaggagga gccctgatgg ctcacgaaag cggcctcaag   6360

gagagcccgt cctgggtgac ccagcgtgcc caggagatgt tccagaagac gggcacatgg   6420

agtccggaac aaggcccccc taccgacatg cccaacagcc agcctaactc tcagtccgtg   6480

gagatgcgag agatgggcag agatggctac tccgacagcg agcactacct ccccatggaa   6540

ggccagggcc gggctgcctc catgccccgc ctccctgcag agaaccagag gagaaggggc   6600

cggccacgtg ggaataacct cagtaccatc tcagacacca gccccatgaa gcgttcagcc   6660

tccgtgctgg gccccaaggc ccgacgcctg gacgattact cgctggagcg ggtcccgccc   6720

gaggagaacc agcggcacca ccagcggcgc cgcgaccgca gccaccgcgc ctctgagcgc   6780

tccctgggcc gctacaccga tgtggacaca ggcttgggga cagacctgag catgaccacc   6840

caatccgggg acctgccgtc gaaggagcgg gaccaggagc ggggccggcc caaggatcgg   6900

aagcatcgac agcaccacca ccaccaccac caccaccacc atcccccgcc ccccgacaag   6960

gaccgctatg cccaggaacg gccggaccac ggccgggcac gggctcggga ccagcgctgg   7020

tcccgctcgc ccagcgaggg ccgagagcac atggcgcacc ggcagggcag tagttccgta   7080

agtggaagcc cagccccctc aacatctggt accagcactc cgcggcgggg ccgccgccag   7140

ctcccccaga ccccctccac cccccggcca cacgtgtcct attcccctgt gatccgtaag   7200

gccggcggct cggggccccc gcagcagcag cagcagcagc agcagcagca gcaggcggtg   7260

gccaggccgg gccgggcggc caccagcggc cctcggaggt acccaggccc cacggccgag   7320

cctctggccg gagatcggcc gcccacgggg ggccacagca gcggccgctc gcccaggatg   7380

gagaggcggg tcccaggccc ggcccggagc gagtccccca gggcctgtcg acacggcggg   7440

gcccggtggc cggcatctgg cccgcacgtg tccgaggggc ccccgggtcc ccggcaccat   7500

ggctactacc ggggctccga ctacgacgag gccgatggcc cgggcagcgg gggcggcgag   7560

gaggccatgg ccggggccta cgacgcgcca ccccccgtac gacacgcgtc ctcgggcgcc   7620

accgggcgct cgcccaggac tccccgggcc tcgggcccgg cctgcgcctc gccttctcgg   7680

cacggccggc gactccccaa cggctactac ccggcgcacg gactggccag gccccgcggg   7740

ccgggctcca ggaagggcct gcacgaaccc tacagcgaga gtgacgatga ttggtgctaa   7800

gcccgggcga gg                                                       7812


<210>  3723
<211>  2505
<212>  PRT
<213>  Homosapiens

<400>  3723

Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu Arg 
            180                 185                 190         


Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr Cys 
                245                 250                 255     


Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp 
305                 310                 315                 320 


Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln 
                725                 730                 735     


Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu 
            740                 745                 750         


Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln 
        755                 760                 765             


Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu Met Arg Lys 
    770                 775                 780                 


Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro 
785                 790                 795                 800 


Asp Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg Pro Asp Met 
                805                 810                 815     


Lys Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg 
            820                 825                 830         


Asn Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr Val Asp Gln 
        835                 840                 845             


Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg 
    850                 855                 860                 


Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala 
865                 870                 875                 880 


Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly 
                885                 890                 895     


Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu 
            900                 905                 910         


Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp 
        915                 920                 925             


Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg 
    930                 935                 940                 


Ser Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg Arg His Arg 
945                 950                 955                 960 


Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg 
                965                 970                 975     


Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly 
            980                 985                 990         


Glu Gly Glu Gly Pro Asp Gly Gly  Glu Arg Arg Arg Arg  His Arg His 
        995                 1000                 1005             


Gly Ala  Pro Ala Thr Tyr Glu  Gly Asp Ala Arg Arg  Glu Asp Lys 
    1010                 1015                 1020             


Glu Arg  Arg His Arg Arg Arg  Lys Glu Asn Gln Gly  Ser Gly Val 
    1025                 1030                 1035             


Pro Val  Ser Gly Pro Asn Leu  Ser Thr Thr Arg Pro  Ile Gln Gln 
    1040                 1045                 1050             


Asp Leu  Gly Arg Gln Asp Pro  Pro Leu Ala Glu Asp  Ile Asp Asn 
    1055                 1060                 1065             


Met Lys  Asn Asn Lys Leu Ala  Thr Ala Glu Ser Ala  Ala Pro His 
    1070                 1075                 1080             


Gly Ser  Leu Gly His Ala Gly  Leu Pro Gln Ser Pro  Ala Lys Met 
    1085                 1090                 1095             


Gly Asn  Ser Thr Asp Pro Gly  Pro Met Leu Ala Ile  Pro Ala Met 
    1100                 1105                 1110             


Ala Thr  Asn Pro Gln Asn Ala  Ala Ser Arg Arg Thr  Pro Asn Asn 
    1115                 1120                 1125             


Pro Gly  Asn Pro Ser Asn Pro  Gly Pro Pro Lys Thr  Pro Glu Asn 
    1130                 1135                 1140             


Ser Leu  Ile Val Thr Asn Pro  Ser Gly Thr Gln Thr  Asn Ser Ala 
    1145                 1150                 1155             


Lys Thr  Ala Arg Lys Pro Asp  His Thr Thr Val Asp  Ile Pro Pro 
    1160                 1165                 1170             


Ala Cys  Pro Pro Pro Leu Asn  His Thr Val Val Gln  Val Asn Lys 
    1175                 1180                 1185             


Asn Ala  Asn Pro Asp Pro Leu  Pro Lys Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Glu Asp Asp Arg  Gly Glu Asp Gly Pro  Lys Pro Met 
    1205                 1210                 1215             


Pro Pro  Tyr Ser Ser Met Phe  Ile Leu Ser Thr Thr  Asn Pro Leu 
    1220                 1225                 1230             


Arg Arg  Leu Cys His Tyr Ile  Leu Asn Leu Arg Tyr  Phe Glu Met 
    1235                 1240                 1245             


Cys Ile  Leu Met Val Ile Ala  Met Ser Ser Ile Ala  Leu Ala Ala 
    1250                 1255                 1260             


Glu Asp  Pro Val Gln Pro Asn  Ala Pro Arg Asn Asn  Val Leu Arg 
    1265                 1270                 1275             


Tyr Phe  Asp Tyr Val Phe Thr  Gly Val Phe Thr Phe  Glu Met Val 
    1280                 1285                 1290             


Ile Lys  Met Ile Asp Leu Gly  Leu Val Leu His Gln  Gly Ala Tyr 
    1295                 1300                 1305             


Phe Arg  Asp Leu Trp Asn Ile  Leu Asp Phe Ile Val  Val Ser Gly 
    1310                 1315                 1320             


Ala Leu  Val Ala Phe Ala Phe  Thr Gly Asn Ser Lys  Gly Lys Asp 
    1325                 1330                 1335             


Ile Asn  Thr Ile Lys Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro 
    1340                 1345                 1350             


Leu Lys  Thr Ile Lys Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp 
    1355                 1360                 1365             


Cys Val  Val Asn Ser Leu Lys  Asn Val Phe Asn Ile  Leu Ile Val 
    1370                 1375                 1380             


Tyr Met  Leu Phe Met Phe Ile  Phe Ala Val Val Ala  Val Gln Leu 
    1385                 1390                 1395             


Phe Lys  Gly Lys Phe Phe His  Cys Thr Asp Glu Ser  Lys Glu Phe 
    1400                 1405                 1410             


Glu Lys  Asp Cys Arg Gly Lys  Tyr Leu Leu Tyr Glu  Lys Asn Glu 
    1415                 1420                 1425             


Val Lys  Ala Arg Asp Arg Glu  Trp Lys Lys Tyr Glu  Phe His Tyr 
    1430                 1435                 1440             


Asp Asn  Val Leu Trp Ala Leu  Leu Thr Leu Phe Thr  Val Ser Thr 
    1445                 1450                 1455             


Gly Glu  Gly Trp Pro Gln Val  Leu Lys His Ser Val  Asp Ala Thr 
    1460                 1465                 1470             


Phe Glu  Asn Gln Gly Pro Ser  Pro Gly Tyr Arg Met  Glu Met Ser 
    1475                 1480                 1485             


Ile Phe  Tyr Val Val Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val 
    1490                 1495                 1500             


Asn Ile  Phe Val Ala Leu Ile  Ile Ile Thr Phe Gln  Glu Gln Gly 
    1505                 1510                 1515             


Asp Lys  Met Met Glu Glu Tyr  Ser Leu Glu Lys Asn  Glu Arg Ala 
    1520                 1525                 1530             


Cys Ile  Asp Phe Ala Ile Ser  Ala Lys Pro Leu Thr  Arg His Met 
    1535                 1540                 1545             


Pro Gln  Asn Lys Gln Ser Phe  Gln Tyr Arg Met Trp  Gln Phe Val 
    1550                 1555                 1560             


Val Ser  Pro Pro Phe Glu Tyr  Thr Ile Met Ala Met  Ile Ala Leu 
    1565                 1570                 1575             


Asn Thr  Ile Val Leu Met Met  Lys Phe Tyr Gly Ala  Ser Val Ala 
    1580                 1585                 1590             


Tyr Glu  Asn Ala Leu Arg Val  Phe Asn Ile Val Phe  Thr Ser Leu 
    1595                 1600                 1605             


Phe Ser  Leu Glu Cys Val Leu  Lys Val Met Ala Phe  Gly Ile Leu 
    1610                 1615                 1620             


Asn Tyr  Phe Arg Asp Ala Trp  Asn Ile Phe Asp Phe  Val Thr Val 
    1625                 1630                 1635             


Leu Gly  Ser Ile Thr Asp Ile  Leu Val Thr Glu Phe  Gly Asn Asn 
    1640                 1645                 1650             


Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe Arg Ala  Ala Arg Leu 
    1655                 1660                 1665             


Ile Lys  Leu Leu Arg Gln Gly  Tyr Thr Ile Arg Ile  Leu Leu Trp 
    1670                 1675                 1680             


Thr Phe  Val Gln Ser Phe Lys  Ala Leu Pro Tyr Val  Cys Leu Leu 
    1685                 1690                 1695             


Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile Ile Gly  Met Gln Val 
    1700                 1705                 1710             


Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp Glu Asp  Ser Asp Glu 
    1715                 1720                 1725             


Asp Glu  Phe Gln Ile Thr Glu  His Asn Asn Phe Arg  Thr Phe Phe 
    1730                 1735                 1740             


Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala Thr Gly  Glu Ala Trp 
    1745                 1750                 1755             


His Asn  Ile Met Leu Ser Cys  Leu Ser Gly Lys Pro  Cys Asp Lys 
    1760                 1765                 1770             


Asn Ser  Gly Ile Leu Thr Arg  Glu Cys Gly Asn Glu  Phe Ala Tyr 
    1775                 1780                 1785             


Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys Ser Phe  Leu Met Leu 
    1790                 1795                 1800             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Glu  Tyr Leu Thr 
    1805                 1810                 1815             


Arg Asp  Ser Ser Ile Leu Gly  Pro His His Leu Asp  Glu Tyr Val 
    1820                 1825                 1830             


Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala Cys Gly  Arg Ile His 
    1835                 1840                 1845             


Tyr Lys  Asp Met Tyr Ser Leu  Leu Arg Val Ile Ser  Pro Pro Leu 
    1850                 1855                 1860             


Gly Leu  Gly Lys Lys Cys Pro  His Arg Val Ala Cys  Lys Arg Leu 
    1865                 1870                 1875             


Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp Asn Thr  Val His Phe 
    1880                 1885                 1890             


Asn Ser  Thr Leu Met Ala Leu  Ile Arg Thr Ala Leu  Asp Ile Lys 
    1895                 1900                 1905             


Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln Met Asp  Ala Glu Leu 
    1910                 1915                 1920             


Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn Leu Ser  Gln Lys Thr 
    1925                 1930                 1935             


Leu Asp  Leu Leu Val Thr Pro  His Lys Ser Thr Asp  Leu Thr Val 
    1940                 1945                 1950             


Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met Glu Tyr  Tyr Arg Gln 
    1955                 1960                 1965             


Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg Glu Glu  Gln Asp Arg 
    1970                 1975                 1980             


Thr Pro  Leu Met Phe Gln Arg  Met Glu Pro Pro Ser  Pro Thr Gln 
    1985                 1990                 1995             


Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro Ser Thr  Gln Leu Asp 
    2000                 2005                 2010             


Pro Gly  Gly Ala Leu Met Ala  His Glu Ser Gly Leu  Lys Glu Ser 
    2015                 2020                 2025             


Pro Ser  Trp Val Thr Gln Arg  Ala Gln Glu Met Phe  Gln Lys Thr 
    2030                 2035                 2040             


Gly Thr  Trp Ser Pro Glu Gln  Gly Pro Pro Thr Asp  Met Pro Asn 
    2045                 2050                 2055             


Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met Arg Glu  Met Gly Arg 
    2060                 2065                 2070             


Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu Pro Met  Glu Gly Gln 
    2075                 2080                 2085             


Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro Ala Glu  Asn Gln Arg 
    2090                 2095                 2100             


Arg Arg  Gly Arg Pro Arg Gly  Asn Asn Leu Ser Thr  Ile Ser Asp 
    2105                 2110                 2115             


Thr Ser  Pro Met Lys Arg Ser  Ala Ser Val Leu Gly  Pro Lys Ala 
    2120                 2125                 2130             


Arg Arg  Leu Asp Asp Tyr Ser  Leu Glu Arg Val Pro  Pro Glu Glu 
    2135                 2140                 2145             


Asn Gln  Arg His His Gln Arg  Arg Arg Asp Arg Ser  His Arg Ala 
    2150                 2155                 2160             


Ser Glu  Arg Ser Leu Gly Arg  Tyr Thr Asp Val Asp  Thr Gly Leu 
    2165                 2170                 2175             


Gly Thr  Asp Leu Ser Met Thr  Thr Gln Ser Gly Asp  Leu Pro Ser 
    2180                 2185                 2190             


Lys Glu  Arg Asp Gln Glu Arg  Gly Arg Pro Lys Asp  Arg Lys His 
    2195                 2200                 2205             


Arg Gln  His His His His His  His His His His His  Pro Pro Pro 
    2210                 2215                 2220             


Pro Asp  Lys Asp Arg Tyr Ala  Gln Glu Arg Pro Asp  His Gly Arg 
    2225                 2230                 2235             


Ala Arg  Ala Arg Asp Gln Arg  Trp Ser Arg Ser Pro  Ser Glu Gly 
    2240                 2245                 2250             


Arg Glu  His Met Ala His Arg  Gln Gly Ser Ser Ser  Val Ser Gly 
    2255                 2260                 2265             


Ser Pro  Ala Pro Ser Thr Ser  Gly Thr Ser Thr Pro  Arg Arg Gly 
    2270                 2275                 2280             


Arg Arg  Gln Leu Pro Gln Thr  Pro Ser Thr Pro Arg  Pro His Val 
    2285                 2290                 2295             


Ser Tyr  Ser Pro Val Ile Arg  Lys Ala Gly Gly Ser  Gly Pro Pro 
    2300                 2305                 2310             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Ala  Val Ala Arg 
    2315                 2320                 2325             


Pro Gly  Arg Ala Ala Thr Ser  Gly Pro Arg Arg Tyr  Pro Gly Pro 
    2330                 2335                 2340             


Thr Ala  Glu Pro Leu Ala Gly  Asp Arg Pro Pro Thr  Gly Gly His 
    2345                 2350                 2355             


Ser Ser  Gly Arg Ser Pro Arg  Met Glu Arg Arg Val  Pro Gly Pro 
    2360                 2365                 2370             


Ala Arg  Ser Glu Ser Pro Arg  Ala Cys Arg His Gly  Gly Ala Arg 
    2375                 2380                 2385             


Trp Pro  Ala Ser Gly Pro His  Val Ser Glu Gly Pro  Pro Gly Pro 
    2390                 2395                 2400             


Arg His  His Gly Tyr Tyr Arg  Gly Ser Asp Tyr Asp  Glu Ala Asp 
    2405                 2410                 2415             


Gly Pro  Gly Ser Gly Gly Gly  Glu Glu Ala Met Ala  Gly Ala Tyr 
    2420                 2425                 2430             


Asp Ala  Pro Pro Pro Val Arg  His Ala Ser Ser Gly  Ala Thr Gly 
    2435                 2440                 2445             


Arg Ser  Pro Arg Thr Pro Arg  Ala Ser Gly Pro Ala  Cys Ala Ser 
    2450                 2455                 2460             


Pro Ser  Arg His Gly Arg Arg  Leu Pro Asn Gly Tyr  Tyr Pro Ala 
    2465                 2470                 2475             


His Gly  Leu Ala Arg Pro Arg  Gly Pro Gly Ser Arg  Lys Gly Leu 
    2480                 2485                 2490             


His Glu  Pro Tyr Ser Glu Ser  Asp Asp Asp Trp Cys  
    2495                 2500                 2505 


<210>  3724
<211>  1042
<212>  DNA
<213>  Homosapiens

<400>  3724
tctgctcaga aaactgctct tcttggcacc cacttttctc cctcctgtct ctgggccacc     60

cttcttcttt ccactgggtg ggccatggat gcatggactt cagatagctc ggacccctgg    120

gtgctgacga gatgggaccc tcgggacccc tggaggactc gcagtgctga ccactagccg    180

cgtcgcctga gccccagcgc tgatgcgata cagtttcccc ctcactgtgc tggagggaga    240

agaccctggg atttctgagc gaggcccgtg gatgttgaag tcttcctggg tccccgactc    300

catgctctcg cgccccagtt actatgacgc cctgcacaac cgcagctcgg ggcacgccca    360

gcgccctgca ggacactcgg cctccccggc tcagcatctg cttcgagggc ccccctctga    420

ggcggcgggg cggcgtggtg gatcaccgag atgtcatctt ggcccaccag gcccacaaaa    480

tccacagcac cccccaggcc aggaggaaag aatgggagaa gctaccagag gatgtgcttc    540

acccaaacaa gggagtaaac caagaagagg gaaacagaga acactggact taagaaatcc    600

aacaatgaga agcaaaggga atctcctgga tgatgataaa gagagagccc aggatgaaag    660

ctgtatgcca gggaaagtcc tgattagacc atgtgacaag tcttcaggaa agactgcttc    720

tggatgataa aatgaactga atacctgtta agagacttgg ggggtcaaat ttgcaataag    780

taccaaacaa agaagattaa aaaatgataa gtcccaaggg aaacaatatg ttgtaaagaa    840

aaagtagcta tagtttgttc atgacataac tgtaacttgc cttgtacatg ataatataaa    900

caccgaatct tcctcacttt gtgaaagaac aatattgggc aaatgcgcag gttttggaaa    960

gttccatgtg tagggggatg gagggagaaa ttagcaaaat cctccttttc tatagctaat   1020

acctataaag tgctacaaca cc                                            1042


<210>  3725
<211>  174
<212>  PRT
<213>  Homosapiens

<400>  3725

Met Arg Tyr Ser Phe Pro Leu Thr Val Leu Glu Gly Glu Asp Pro Gly 
1               5                   10                  15      


Ile Ser Glu Arg Gly Pro Trp Met Leu Lys Ser Ser Trp Val Pro Asp 
            20                  25                  30          


Ser Met Leu Ser Arg Pro Ser Tyr Tyr Asp Ala Leu His Asn Arg Ser 
        35                  40                  45              


Ser Gly His Ala Gln Arg Pro Ala Gly His Ser Ala Ser Pro Ala Gln 
    50                  55                  60                  


His Leu Leu Arg Gly Pro Pro Ser Glu Ala Ala Gly Arg Arg Gly Gly 
65                  70                  75                  80  


Ser Pro Arg Cys His Leu Gly Pro Pro Gly Pro Gln Asn Pro Gln His 
                85                  90                  95      


Pro Pro Gly Gln Glu Glu Arg Met Gly Glu Ala Thr Arg Gly Cys Ala 
            100                 105                 110         


Ser Pro Lys Gln Gly Ser Lys Pro Arg Arg Gly Lys Gln Arg Thr Leu 
        115                 120                 125             


Asp Leu Arg Asn Pro Thr Met Arg Ser Lys Gly Asn Leu Leu Asp Asp 
    130                 135                 140                 


Asp Lys Glu Arg Ala Gln Asp Glu Ser Cys Met Pro Gly Lys Val Leu 
145                 150                 155                 160 


Ile Arg Pro Cys Asp Lys Ser Ser Gly Lys Thr Ala Ser Gly 
                165                 170                 


<210>  3726
<211>  1061
<212>  DNA
<213>  Homosapiens

<400>  3726
gagacggact cttgctatgt tgcccaggct ggtcttgaac tcctggcctc aagcaatcct     60

cctgcctcag cctcccaaag cacggggatt acaaaccctg ctgagggatg cccaagaagt    120

tccagggtga gaacaccaag tcggcagcgg cccgggcacg gagggcagag gccaaggcgg    180

ccgctgatgc caagaagcag aaggagctgg aggatgccta ctggaaggac gacgacaaac    240

acgtcatgag gaaggagcag cgcaaggagg agaaggagaa gcggcgcctc gaccagctgg    300

aacgtaagaa ggagacgcag cgcctactgg aggaggagga ctccaagctc aagggcggca    360

aggcgccgcg ggtggccacg tccagcaagg tcacccgggc ccagatcgag gacacgctgc    420

gccgagacca tcagctcagg gaggccccgg acacagccga gaaagccaag agccatctgg    480

aggtgccgct ggaggagaac gtgaaccgcc gcgtgctgga ggagggcagc gtggaggcgc    540

gcaccatcga ggacgccatt gcagtgctca gcgtggcgga ggaggcggcc gaccggcacc    600

cagaaagacg catgcgggca gccttcacag cctttgagga agcccagctg ccgcggctca    660

aacaagagaa ccccaacatg cggctgtcgc agctgaaaca gctgctcaag aaggagtggc    720

tccgctctcc tgacaacccc atgaaccagc gggccgtgcc cttcaatgcc cccaagtgag    780

cccagaactt ggggagccag ttcacccacg gggtggtcca ggtcacgact ctgcacgccc    840

ttaggccagg tcagctgcga gggtcacaga gcgttccggg ggccaaggcg ccgggccccg    900

gggccatgct cttatcacca gccacccgtc ctcccgccag agggtccctg ccccgagtga    960

caccccatcc cctcccatcc cccggcgcgt gtgtgtagag cctcagggct gagtgcccaa   1020

taaaggtggc ggcaaggcta aaaaaaaaaa aaaaaaaaaa a                       1061


<210>  3727
<211>  223
<212>  PRT
<213>  Homosapiens

<400>  3727

Met Pro Lys Lys Phe Gln Gly Glu Asn Thr Lys Ser Ala Ala Ala Arg 
1               5                   10                  15      


Ala Arg Arg Ala Glu Ala Lys Ala Ala Ala Asp Ala Lys Lys Gln Lys 
            20                  25                  30          


Glu Leu Glu Asp Ala Tyr Trp Lys Asp Asp Asp Lys His Val Met Arg 
        35                  40                  45              


Lys Glu Gln Arg Lys Glu Glu Lys Glu Lys Arg Arg Leu Asp Gln Leu 
    50                  55                  60                  


Glu Arg Lys Lys Glu Thr Gln Arg Leu Leu Glu Glu Glu Asp Ser Lys 
65                  70                  75                  80  


Leu Lys Gly Gly Lys Ala Pro Arg Val Ala Thr Ser Ser Lys Val Thr 
                85                  90                  95      


Arg Ala Gln Ile Glu Asp Thr Leu Arg Arg Asp His Gln Leu Arg Glu 
            100                 105                 110         


Ala Pro Asp Thr Ala Glu Lys Ala Lys Ser His Leu Glu Val Pro Leu 
        115                 120                 125             


Glu Glu Asn Val Asn Arg Arg Val Leu Glu Glu Gly Ser Val Glu Ala 
    130                 135                 140                 


Arg Thr Ile Glu Asp Ala Ile Ala Val Leu Ser Val Ala Glu Glu Ala 
145                 150                 155                 160 


Ala Asp Arg His Pro Glu Arg Arg Met Arg Ala Ala Phe Thr Ala Phe 
                165                 170                 175     


Glu Glu Ala Gln Leu Pro Arg Leu Lys Gln Glu Asn Pro Asn Met Arg 
            180                 185                 190         


Leu Ser Gln Leu Lys Gln Leu Leu Lys Lys Glu Trp Leu Arg Ser Pro 
        195                 200                 205             


Asp Asn Pro Met Asn Gln Arg Ala Val Pro Phe Asn Ala Pro Lys 
    210                 215                 220             


<210>  3728
<211>  2657
<212>  DNA
<213>  Homosapiens

<400>  3728
ggtggtctga gctggagcca cgctttctgt tggagggggc agctgaagga gaacagcaag     60

acatatccgg cggccctacg gactcggaga gctggaggga ccccggagat ctcaaaggga    120

caggaaaggc agcagcagcc accctctctc ccagtcaagt ggtcaccagc aggactgaag    180

gggacagccc ctttgcagtg gctcggcgag gagacccctg caccctaggg tcagtgcagg    240

agcccagccg ctgagccatg ccgggccccg ggcggcctgc agcgagccca acccctgcac    300

ccaggtagtc atgaacagcc acagctacaa tggcagcgtg gggcggccgc tgggcagcgg    360

gccgggcgcc ctgggacgag accctccgga ccctgaggcc ggccaccccc cacaaccccc    420

gcacagcccg ggcctccagg tggtagtggc caagagtgag ccagcccggc cctcacccgg    480

cagcccccgg gggcagcccc aggaccagga cgatgacgag gatgatgagg aagatgaggc    540

cggcaggcag agagcctcgg ggaaaccctc aaatgtgggc caccgcctgg gccaccggcg    600

ggcgctcttc gagaagcgga agcgcctcag cgactatgcc ctcattttcg gcatgtttgg    660

catcgtcgtc atggtgacgg agaccgagct gtcctggggg gtgtacacca aggagtctct    720

gtactcattc gcactcaaat gcctcatcag cctctccacg gccatcctgc tgggtctcgt    780

tgtcctctac catgcccggg agatccagct gttcatggtg gacaacgggg ctgatgactg    840

gcgcatcgcc atgacctgcg agcgcgtgtt cctcatctcg ctagagctgg cagtgtgcgc    900

cattcacccg gtgcccggcc actaccgctt cacgtggacg gcgcggctgg ccttcacgta    960

cgcgccctcg gtggccgagg ccgacgtgga cgtgctgctg tccatcccca tgttcctgcg   1020

cctctacctg ctgggccggg tgatgctact gcacagcaaa atcttcacgg acgcctcgag   1080

ccgcagcatc ggggccctca acaagatcac cttcaacacg cgcttcgtca tgaagacact   1140

catgaccatc tgccccggca ccgtgctgct ggtcttcagc atctcctcct ggatcatcgc   1200

agcctggacc gtgcgcgtct gcgagaggta ccacgacaag caggaagtga ccagcaactt   1260

cctgggggcc atgtggctga tttccatcac cttcctctcc attggctacg gcgacatggt   1320

gccccacacc tactgcggga agggtgtgtg cctgctcact ggcatcatgg gagctggctg   1380

taccgcgctc gtggtggctg tggtggctcg gaagctggag ctcaccaagg ctgagaagca   1440

cgtgcacaac ttcatgatgg acactcagct caccaagcgg gtaaaaaacg ccgctgctaa   1500

cgttctcagg gagacgtggc tcatctacaa acataccagg ctggtgaaga agccagacca   1560

agcccgggtt cggaaacacc agcgtaagtt cctccaagcc atccatcagg ctcagaagct   1620

ccggagtgtg aagatcgagc aagggaagct gaacgaccag gctaacacgc ttaccgacct   1680

agccaagacc cagaccgtca tgtacgacct tgtatcggag ctgcacgctc agcacgagga   1740

gctggaggcc cgcctggcca ccctggaaag ccgcttggat gcgctgggtg cctctctaca   1800

ggccctgcct ggcctcatcg cccaagccat acgcccaccc ccgcctcccc tgcctcccag   1860

gcccggcccc ggcccccaag accaggcagc ccggagctcc ccctgccggt ggacgcccgt   1920

ggccccctcg gactgcgggt gacggccctg cccgccacca gacccctaaa tcttggccat   1980

cgtgtggccg ccacctccgg gaagccttgt acagtggcgc ctcttggagt tcaagaagcc   2040

aacgctgagt caggctgagt ggactgaggc ctgccccgcc cagactgccc aggcagaggg   2100

cagggctgga ccatgggtga gggcagggga gcccggagct tcctctggtc acctggtccc   2160

ccgactctcc ccaggccccc ggtgggcatg gagcagcccg gggaggggtc cgtgctggtt   2220

ctgaataaag caggacccgc ctagtggctg cctgtgtgca tggctggaag gcactggtga   2280

tgtcccagga ggtagacctc cagccctggg taccaagatg aatgtgggaa tcagaaaaac   2340

ctgttcccat caccggccta gcctagaatc ctagcctaga agccctctct ccctctgggc   2400

tggagctcag tgagggacaa ctctctaggg acacctgtac cagccccacc tggcgctgag   2460

atccctcaga cagcatggcc cagccctggc cagaagcatc gctccccttc aaccaaccgc   2520

gttgatggac acccactgtg tgccaggccc cagcggggcc catgggggag gtgacctggg   2580

tgaggaaggt catttgggtt tttgtgagat ttgtattgag cacctgctgt ctacagagaa   2640

tgtgatgatg tcaatta                                                  2657


<210>  3729
<211>  543
<212>  PRT
<213>  Homosapiens

<400>  3729

Met Asn Ser His Ser Tyr Asn Gly Ser Val Gly Arg Pro Leu Gly Ser 
1               5                   10                  15      


Gly Pro Gly Ala Leu Gly Arg Asp Pro Pro Asp Pro Glu Ala Gly His 
            20                  25                  30          


Pro Pro Gln Pro Pro His Ser Pro Gly Leu Gln Val Val Val Ala Lys 
        35                  40                  45              


Ser Glu Pro Ala Arg Pro Ser Pro Gly Ser Pro Arg Gly Gln Pro Gln 
    50                  55                  60                  


Asp Gln Asp Asp Asp Glu Asp Asp Glu Glu Asp Glu Ala Gly Arg Gln 
65                  70                  75                  80  


Arg Ala Ser Gly Lys Pro Ser Asn Val Gly His Arg Leu Gly His Arg 
                85                  90                  95      


Arg Ala Leu Phe Glu Lys Arg Lys Arg Leu Ser Asp Tyr Ala Leu Ile 
            100                 105                 110         


Phe Gly Met Phe Gly Ile Val Val Met Val Thr Glu Thr Glu Leu Ser 
        115                 120                 125             


Trp Gly Val Tyr Thr Lys Glu Ser Leu Tyr Ser Phe Ala Leu Lys Cys 
    130                 135                 140                 


Leu Ile Ser Leu Ser Thr Ala Ile Leu Leu Gly Leu Val Val Leu Tyr 
145                 150                 155                 160 


His Ala Arg Glu Ile Gln Leu Phe Met Val Asp Asn Gly Ala Asp Asp 
                165                 170                 175     


Trp Arg Ile Ala Met Thr Cys Glu Arg Val Phe Leu Ile Ser Leu Glu 
            180                 185                 190         


Leu Ala Val Cys Ala Ile His Pro Val Pro Gly His Tyr Arg Phe Thr 
        195                 200                 205             


Trp Thr Ala Arg Leu Ala Phe Thr Tyr Ala Pro Ser Val Ala Glu Ala 
    210                 215                 220                 


Asp Val Asp Val Leu Leu Ser Ile Pro Met Phe Leu Arg Leu Tyr Leu 
225                 230                 235                 240 


Leu Gly Arg Val Met Leu Leu His Ser Lys Ile Phe Thr Asp Ala Ser 
                245                 250                 255     


Ser Arg Ser Ile Gly Ala Leu Asn Lys Ile Thr Phe Asn Thr Arg Phe 
            260                 265                 270         


Val Met Lys Thr Leu Met Thr Ile Cys Pro Gly Thr Val Leu Leu Val 
        275                 280                 285             


Phe Ser Ile Ser Ser Trp Ile Ile Ala Ala Trp Thr Val Arg Val Cys 
    290                 295                 300                 


Glu Arg Tyr His Asp Lys Gln Glu Val Thr Ser Asn Phe Leu Gly Ala 
305                 310                 315                 320 


Met Trp Leu Ile Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp Met 
                325                 330                 335     


Val Pro His Thr Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly Ile 
            340                 345                 350         


Met Gly Ala Gly Cys Thr Ala Leu Val Val Ala Val Val Ala Arg Lys 
        355                 360                 365             


Leu Glu Leu Thr Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
    370                 375                 380                 


Thr Gln Leu Thr Lys Arg Val Lys Asn Ala Ala Ala Asn Val Leu Arg 
385                 390                 395                 400 


Glu Thr Trp Leu Ile Tyr Lys His Thr Arg Leu Val Lys Lys Pro Asp 
                405                 410                 415     


Gln Ala Arg Val Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile His 
            420                 425                 430         


Gln Ala Gln Lys Leu Arg Ser Val Lys Ile Glu Gln Gly Lys Leu Asn 
        435                 440                 445             


Asp Gln Ala Asn Thr Leu Thr Asp Leu Ala Lys Thr Gln Thr Val Met 
    450                 455                 460                 


Tyr Asp Leu Val Ser Glu Leu His Ala Gln His Glu Glu Leu Glu Ala 
465                 470                 475                 480 


Arg Leu Ala Thr Leu Glu Ser Arg Leu Asp Ala Leu Gly Ala Ser Leu 
                485                 490                 495     


Gln Ala Leu Pro Gly Leu Ile Ala Gln Ala Ile Arg Pro Pro Pro Pro 
            500                 505                 510         


Pro Leu Pro Pro Arg Pro Gly Pro Gly Pro Gln Asp Gln Ala Ala Arg 
        515                 520                 525             


Ser Ser Pro Cys Arg Trp Thr Pro Val Ala Pro Ser Asp Cys Gly 
    530                 535                 540             


<210>  3730
<211>  2539
<212>  DNA
<213>  Homosapiens

<400>  3730
ggaagttcgc cgacgacgcg cccgccctgg gccaccggcg ccggcccaag ttcgccgggg     60

gggcccggag gaagcttggg ggacgcgacg ggggaacgcg gaaaccccgg ggatctgcag    120

gcgcgcccgg gccgtgtgcc ttctctccgc gtgtccaaac cgtgtcccca gccgcgcgcc    180

atgcgctctg ggggcgtgcg cagcttcgcg ctggagctgg cgcggggccc gggcggcgcc    240

taccgcggcg gggagcggct gtgcggccgg gtgctgctgg aggcggcggc gccgctgcgg    300

gtgcgagcgc tcgaggtgaa ggcgcgcggc ggggcggcca cccactggtt ggagggtcgc    360

agcgtgggcg tcaacgccgt atccagcgac tacgcggccg cggagaccta cctgcggcgt    420

cggcagctgc tgctccgaga taccggggag accacgacgc tgcctcctgg gcgccatgag    480

ttcctgttca gcttccagct gcccccgacc ctggtgacat ccttcgaggg caaacacggt    540

agtgtccgct actgtatcaa ggccaccctg caccggccct gggtcccagc acgccgggca    600

aggaaggtgt tcactgtcat cgagcctgtg gacatcaaca cgccagccct gctggcacct    660

caagcggggg ctcgggaaaa ggttgcccga tcctggtact gtaaccgtgg cctagtctcc    720

ctttcggcca agatcgaccg caagggctac accccaggag aggtcatccc tgtctttgcc    780

gagatcgaca acggctccac acgtcctgtg ctgcctcggg cagccgtggt gcagacacag    840

acgttcatgg cccgaggcgc ccgaaagcag aaacgggcag tggtggccag cctcgcgggc    900

gagccggtgg gccccgggca gcgggcgctg tggcagggcc gggcactgcg gatcccccca    960

gtgggtcctt ccatcctgca ctgccgcgtt ctacacgtgg actacgcact caaggtctgt   1020

gtggatatcc caggaacgtc caagctgctg ctggagctgc cactggtgat cggcaccatt   1080

cccttgcacc cttttggcag ccgttcctcc agcgtgggca gccacgccag cttcctgctg   1140

gactggaggc tgggggcctt gccggagcgg cctgaggctc ctcctgagta ctcggaggtg   1200

gtagccgaca ctgaggaggc agccttgggg cagagcccct tcccgcttcc gcaggacccc   1260

gacatgagcc ttgaaggccc gttcttcgcc tacatccaag agttccgcta ccgcccgcca   1320

cccctgtact ctgaggagga tccaaaccca ctcttggggg acatgaggcc gcgctgcatg   1380

acttgctgaa cggcacaggg acccctcgag gaacaaggtt gcacaccagc tttcagccac   1440

catgactgtg gggagtggct ggaccaaggg ctgacctccc cgactgcatc aaagttgggg   1500

aaccaagtct cagagtgagg cgggggcctt tcggatatca catgggacag aggaagagcc   1560

cggctggaat ctgacttacc tggaccgctg tccttgtgag gcattgaatg cccagtgcag   1620

tatccgagag actgtttaat aacctgtctt cccagccaat tggtggtgct ggaatcccct   1680

aggagccttc agtctgggag aaacagagcc agacatagac agttccagca tcacagaacc   1740

agaagaagag acctgcaact gtgagagtcc agacaggaag cagagaaggc gtccttgcgg   1800

aaagggcatt ttagctgagg ctttggagta cgaataggag ctcagcaggc agacgaatga   1860

ggaataaagg tcagagaagg tcagagctga gtgacgtttg gaatccaccc cgtttattgt   1920

agaactgggg gttcagaggg caggtgcctc agagttgagg ccacacagtg aggtctggtg   1980

ggtgaaagga cccaggaacg aggcgttcag gaaagcaggt tgtcagagct atgtggagtc   2040

tgtgggtggc aggggcagcc gctccagcct ttgaagactt tgaaagccag agattcctgg   2100

cgcaggcttg gacttcctgg gagctcctcc aagtacccag gggcatcaga gctgcctggg   2160

tgttacatgg cccagggaac ccaggttcag ggtaggacag gcaagaccag atacccaatg   2220

tgcaaagtga aaacactggg ctccctgtta aacgatgaag aattcaagac agtgacagca   2280

ttacgtcacc cctggggaca gaggtcagcc taaggtgaca cacggggact actgtgcttc   2340

cggaggctcc ctgtgtcctg gaggagaaaa gcattagagg gggcagctgg acaagctccc   2400

aactgcagag tcccagccct ggctggggca gggccccggc ctgggactca gcatttctga   2460

tatgccttaa gaattcattc tgttttgtac aattattttt taaaagtaaa cgtgtggaga   2520

aagaaaaaaa aaaaaaaaa                                                2539


<210>  3731
<211>  402
<212>  PRT
<213>  Homosapiens

<400>  3731

Met Arg Ser Gly Gly Val Arg Ser Phe Ala Leu Glu Leu Ala Arg Gly 
1               5                   10                  15      


Pro Gly Gly Ala Tyr Arg Gly Gly Glu Arg Leu Cys Gly Arg Val Leu 
            20                  25                  30          


Leu Glu Ala Ala Ala Pro Leu Arg Val Arg Ala Leu Glu Val Lys Ala 
        35                  40                  45              


Arg Gly Gly Ala Ala Thr His Trp Leu Glu Gly Arg Ser Val Gly Val 
    50                  55                  60                  


Asn Ala Val Ser Ser Asp Tyr Ala Ala Ala Glu Thr Tyr Leu Arg Arg 
65                  70                  75                  80  


Arg Gln Leu Leu Leu Arg Asp Thr Gly Glu Thr Thr Thr Leu Pro Pro 
                85                  90                  95      


Gly Arg His Glu Phe Leu Phe Ser Phe Gln Leu Pro Pro Thr Leu Val 
            100                 105                 110         


Thr Ser Phe Glu Gly Lys His Gly Ser Val Arg Tyr Cys Ile Lys Ala 
        115                 120                 125             


Thr Leu His Arg Pro Trp Val Pro Ala Arg Arg Ala Arg Lys Val Phe 
    130                 135                 140                 


Thr Val Ile Glu Pro Val Asp Ile Asn Thr Pro Ala Leu Leu Ala Pro 
145                 150                 155                 160 


Gln Ala Gly Ala Arg Glu Lys Val Ala Arg Ser Trp Tyr Cys Asn Arg 
                165                 170                 175     


Gly Leu Val Ser Leu Ser Ala Lys Ile Asp Arg Lys Gly Tyr Thr Pro 
            180                 185                 190         


Gly Glu Val Ile Pro Val Phe Ala Glu Ile Asp Asn Gly Ser Thr Arg 
        195                 200                 205             


Pro Val Leu Pro Arg Ala Ala Val Val Gln Thr Gln Thr Phe Met Ala 
    210                 215                 220                 


Arg Gly Ala Arg Lys Gln Lys Arg Ala Val Val Ala Ser Leu Ala Gly 
225                 230                 235                 240 


Glu Pro Val Gly Pro Gly Gln Arg Ala Leu Trp Gln Gly Arg Ala Leu 
                245                 250                 255     


Arg Ile Pro Pro Val Gly Pro Ser Ile Leu His Cys Arg Val Leu His 
            260                 265                 270         


Val Asp Tyr Ala Leu Lys Val Cys Val Asp Ile Pro Gly Thr Ser Lys 
        275                 280                 285             


Leu Leu Leu Glu Leu Pro Leu Val Ile Gly Thr Ile Pro Leu His Pro 
    290                 295                 300                 


Phe Gly Ser Arg Ser Ser Ser Val Gly Ser His Ala Ser Phe Leu Leu 
305                 310                 315                 320 


Asp Trp Arg Leu Gly Ala Leu Pro Glu Arg Pro Glu Ala Pro Pro Glu 
                325                 330                 335     


Tyr Ser Glu Val Val Ala Asp Thr Glu Glu Ala Ala Leu Gly Gln Ser 
            340                 345                 350         


Pro Phe Pro Leu Pro Gln Asp Pro Asp Met Ser Leu Glu Gly Pro Phe 
        355                 360                 365             


Phe Ala Tyr Ile Gln Glu Phe Arg Tyr Arg Pro Pro Pro Leu Tyr Ser 
    370                 375                 380                 


Glu Glu Asp Pro Asn Pro Leu Leu Gly Asp Met Arg Pro Arg Cys Met 
385                 390                 395                 400 


Thr Cys 
        


<210>  3732
<211>  2518
<212>  DNA
<213>  Homosapiens

<400>  3732
gggattttct gctccggttg gtgagcgcgc ctgcgcgttg acggcgattt tgcgttctga     60

ggctgcagcg tcggcatctt gagctgccgg ttcgcgagtt cgaggccagg ttccgcctgt    120

cgtgggttcg caccccggac gcgatgctat tcgacaaggt gaaagcgttc tcggtgcagt    180

tggacggcgc gaccgcgggc gtcgagcccg tgtttagcgg cggccaggcc gtggcgggcc    240

gggtgctgct ggagctgtca agcgccgcgc gtgtgggtgc cctgaggctg cgcgcgcggg    300

gccgcgccca cgtgcactgg accgagtcgc gcagcgcggg ctcgagcacg gcttacacgc    360

agagctacag tgaacgcgtg gaggtcgtga gccaccgcgc cacgctcctg gcgccagata    420

ccggggagac cacgacgctg cctcctgggc gccatgagtt cctgttcagc ttccagctgc    480

ccccgaccct ggtgacatcc ttcgagggca aacacggtag tgtccgctac tgtatcaagg    540

ccaccctgca ccggccctgg gtcccagcac gccgggcaag gaaggtgttc actgtcatcg    600

agcctgtgga catcaacacg ccagccctgc tggcacctca agcgggggct cgggaaaagg    660

ttgcccgatc ctggtactgt aaccgtggcc tagtctccct ttcggccaag atcgaccgca    720

agggctacac cccaggagag gtcatccctg tctttgccga gatcgacaac ggctccacac    780

gtcctgtgct gcctcgggca gccgtggtgc agacacagac gttcatggcc cgaggcgccc    840

gaaagcagaa acgggcagtg gtggccagcc tcgcgggcga gccggtgggc cccgggcagc    900

gggcgctgtg gcagggccgg gcactgcgga tccccccagt gggtccttcc atcctgcact    960

gccgcgttct acacgtggac tacgcactca aggtctgtgt ggatatccca ggaacgtcca   1020

agctgctgct ggagctgcca ctggtgatcg gcaccattcc cttgcaccct tttggcagcc   1080

gttcctccag cgtgggcagc cacgccagct tcctgctgga ctggaggctg ggggccttgc   1140

cggagcggcc tgaggctcct cctgagtact cggaggtggt agccgacact gaggaggcag   1200

ccttggggca gagccccttc ccgcttccgc aggaccccga catgagcctt gaaggcccgt   1260

tcttcgccta catccaagag ttccgctacc gcccgccacc cctgtactct gaggaggatc   1320

caaacccact cttgggggac atgaggccgc gctgcatgac ttgctgaacg gcacagggac   1380

ccctcgagga acaaggttgc acaccagctt tcagccacca tgactgtggg gagtggctgg   1440

accaagggct gacctccccg actgcatcaa agttggggaa ccaagtctca gagtgaggcg   1500

ggggcctttc ggatatcaca tgggacagag gaagagcccg gctggaatct gacttacctg   1560

gaccgctgtc cttgtgaggc attgaatgcc cagtgcagta tccgagagac tgtttaataa   1620

cctgtcttcc cagccaattg gtggtgctgg aatcccctag gagccttcag tctgggagaa   1680

acagagccag acatagacag ttccagcatc acagaaccag aagaagagac ctgcaactgt   1740

gagagtccag acaggaagca gagaaggcgt ccttgcggaa agggcatttt agctgaggct   1800

ttggagtacg aataggagct cagcaggcag acgaatgagg aataaaggtc agagaaggtc   1860

agagctgagt gacgtttgga atccaccccg tttattgtag aactgggggt tcagagggca   1920

ggtgcctcag agttgaggcc acacagtgag gtctggtggg tgaaaggacc caggaacgag   1980

gcgttcagga aagcaggttg tcagagctat gtggagtctg tgggtggcag gggcagccgc   2040

tccagccttt gaagactttg aaagccagag attcctggcg caggcttgga cttcctggga   2100

gctcctccaa gtacccaggg gcatcagagc tgcctgggtg ttacatggcc cagggaaccc   2160

aggttcaggg taggacaggc aagaccagat acccaatgtg caaagtgaaa acactgggct   2220

ccctgttaaa cgatgaagaa ttcaagacag tgacagcatt acgtcacccc tggggacaga   2280

ggtcagccta aggtgacaca cggggactac tgtgcttccg gaggctccct gtgtcctgga   2340

ggagaaaagc attagagggg gcagctggac aagctcccaa ctgcagagtc ccagccctgg   2400

ctggggcagg gccccggcct gggactcagc atttctgata tgccttaaga attcattctg   2460

ttttgtacaa ttatttttta aaagtaaacg tgtggagaaa gaaaaaaaaa aaaaaaaa     2518


<210>  3733
<211>  407
<212>  PRT
<213>  Homosapiens

<400>  3733

Met Leu Phe Asp Lys Val Lys Ala Phe Ser Val Gln Leu Asp Gly Ala 
1               5                   10                  15      


Thr Ala Gly Val Glu Pro Val Phe Ser Gly Gly Gln Ala Val Ala Gly 
            20                  25                  30          


Arg Val Leu Leu Glu Leu Ser Ser Ala Ala Arg Val Gly Ala Leu Arg 
        35                  40                  45              


Leu Arg Ala Arg Gly Arg Ala His Val His Trp Thr Glu Ser Arg Ser 
    50                  55                  60                  


Ala Gly Ser Ser Thr Ala Tyr Thr Gln Ser Tyr Ser Glu Arg Val Glu 
65                  70                  75                  80  


Val Val Ser His Arg Ala Thr Leu Leu Ala Pro Asp Thr Gly Glu Thr 
                85                  90                  95      


Thr Thr Leu Pro Pro Gly Arg His Glu Phe Leu Phe Ser Phe Gln Leu 
            100                 105                 110         


Pro Pro Thr Leu Val Thr Ser Phe Glu Gly Lys His Gly Ser Val Arg 
        115                 120                 125             


Tyr Cys Ile Lys Ala Thr Leu His Arg Pro Trp Val Pro Ala Arg Arg 
    130                 135                 140                 


Ala Arg Lys Val Phe Thr Val Ile Glu Pro Val Asp Ile Asn Thr Pro 
145                 150                 155                 160 


Ala Leu Leu Ala Pro Gln Ala Gly Ala Arg Glu Lys Val Ala Arg Ser 
                165                 170                 175     


Trp Tyr Cys Asn Arg Gly Leu Val Ser Leu Ser Ala Lys Ile Asp Arg 
            180                 185                 190         


Lys Gly Tyr Thr Pro Gly Glu Val Ile Pro Val Phe Ala Glu Ile Asp 
        195                 200                 205             


Asn Gly Ser Thr Arg Pro Val Leu Pro Arg Ala Ala Val Val Gln Thr 
    210                 215                 220                 


Gln Thr Phe Met Ala Arg Gly Ala Arg Lys Gln Lys Arg Ala Val Val 
225                 230                 235                 240 


Ala Ser Leu Ala Gly Glu Pro Val Gly Pro Gly Gln Arg Ala Leu Trp 
                245                 250                 255     


Gln Gly Arg Ala Leu Arg Ile Pro Pro Val Gly Pro Ser Ile Leu His 
            260                 265                 270         


Cys Arg Val Leu His Val Asp Tyr Ala Leu Lys Val Cys Val Asp Ile 
        275                 280                 285             


Pro Gly Thr Ser Lys Leu Leu Leu Glu Leu Pro Leu Val Ile Gly Thr 
    290                 295                 300                 


Ile Pro Leu His Pro Phe Gly Ser Arg Ser Ser Ser Val Gly Ser His 
305                 310                 315                 320 


Ala Ser Phe Leu Leu Asp Trp Arg Leu Gly Ala Leu Pro Glu Arg Pro 
                325                 330                 335     


Glu Ala Pro Pro Glu Tyr Ser Glu Val Val Ala Asp Thr Glu Glu Ala 
            340                 345                 350         


Ala Leu Gly Gln Ser Pro Phe Pro Leu Pro Gln Asp Pro Asp Met Ser 
        355                 360                 365             


Leu Glu Gly Pro Phe Phe Ala Tyr Ile Gln Glu Phe Arg Tyr Arg Pro 
    370                 375                 380                 


Pro Pro Leu Tyr Ser Glu Glu Asp Pro Asn Pro Leu Leu Gly Asp Met 
385                 390                 395                 400 


Arg Pro Arg Cys Met Thr Cys 
                405         


<210>  3734
<211>  2100
<212>  DNA
<213>  Homosapiens

<400>  3734
ggtggctgaa cctcgcaggt ggcagagagg ctcccctggg gctgtggggc tctacgtgga     60

tccgatggag ccgctggtga cctgggtggt ccccctcctc ttcctcttcc tgctgtccag    120

gcagggcgct gcctgcagaa ccagtgagtg ctgttttcag gacccgccat atccggatgc    180

agactcaggc tcggcctcgg gccctaggga cctgagatgc tatcggatat ccagtgatcg    240

ttacgagtgc tcctggcagt atgagggtcc cacagctggg gtcagccact tcctgcggtg    300

ttgccttagc tccgggcgct gctgctactt cgccgccggc tcagccacca ggctgcagtt    360

ctccgaccag gctggggtgt ctgtgctgta cactgtcaca ctctgggtgg aatcctgggc    420

caggaaccag acagagaagt ctcctgaggt gaccctgcag ctctacaact cagttaaata    480

tgagcctcct ctgggagaca tcaaggtgtc caagttggcc gggcagctgc gtatggagtg    540

ggagaccccg gataaccagg ttggtgctga ggtgcagttc cggcaccgga cacccagcag    600

cccatggaag ttgggcgact gcggacctca ggatgatgat actgagtcct gcctctgccc    660

cctggagatg aatgtggccc aggaattcca gctccgacga cggcagctgg ggagccaagg    720

aagttcctgg agcaagtgga gcagccccgt gtgcgttccc cctgaaaacc ccccacagcc    780

tcaggtgaga ttctcggtgg agcagctggg ccaggatggg aggaggcggc tgaccctgaa    840

agagcagcca acccagctgg agcttccaga aggctgtcaa gggctggcgc ctggcacgga    900

ggtcacttac cgactacagc tccacatgct gtcctgcccg tgtaaggcca aggccaccag    960

gaccctgcac ctggggaaga tgccctatct ctcgggtgct gcctacaacg tggctgtcat   1020

ctcctcgaac caatttggtc ctggcctgaa ccagacgtgg cacattcctg ccgacaccca   1080

cacagaacca gtggctctga atatcagcgt cggaaccaac gggaccacca tgtattggcc   1140

agcccgggct cagagcatga cgtattgcat tgaatggcag cctgtgggcc aggacggggg   1200

ccttgccacc tgcagcctga ctgcgccgca agacccggat ccggctggaa tggcaaccta   1260

cagctggagt cgagagtctg gggcaatggg gcaggaaaag tgttactaca ttaccatctt   1320

tgcctctgcg caccccgaga agctcacctt gtggtctacg gtcctgtcca cctaccactt   1380

tgggggcaat gcctcagcag ctgggacacc gcaccacgtc tcggtgaaga atcatagctt   1440

ggactctgtg tctgtggact gggcaccatc cctgctgagc acctgtcccg gcgtcctaaa   1500

ggagtatgtt gtccgctgcc gagatgaaga cagcaaacag gtgtcagagc atcccgtgca   1560

gcccacagag acccaagtta ccctcagtgg cctgcgggct ggtgtagcct acacggtgca   1620

ggtgcgagca gacacagcgt ggctgagggg tgtctggagc cagccccagc gcttcagcat   1680

cgaagtgcag gtttctgatt ggctcatctt cttcgcctcc ctggggagct tcctgagcat   1740

ccttctcgtg ggcgtccttg gctaccttgg cctgaacagg gccgcacggc acctgtgccc   1800

gccgctgccc acaccctgtg ccagctccgc cattgagttc cctggaggga aggagacttg   1860

gcagtggatc aacccagtgg acttccagga agaggcatcc ctgcaggagg ccctggtggt   1920

agagatgtcc tgggacaaag gcgagaggac tgagcctctc gagaagacag agctacctga   1980

gggtgcccct gagctggccc tggatacaga gttgtccttg gaggatggag acaggtgcaa   2040

ggccaagatg tgatcgttga ggctcagaga gggtgagtga ctcgcccgag gctacgtagc   2100


<210>  3735
<211>  662
<212>  PRT
<213>  Homosapiens

<400>  3735

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Glu Pro Val Ala Leu Asn Ile Ser Val Gly Thr Asn 
            340                 345                 350         


Gly Thr Thr Met Tyr Trp Pro Ala Arg Ala Gln Ser Met Thr Tyr Cys 
        355                 360                 365             


Ile Glu Trp Gln Pro Val Gly Gln Asp Gly Gly Leu Ala Thr Cys Ser 
    370                 375                 380                 


Leu Thr Ala Pro Gln Asp Pro Asp Pro Ala Gly Met Ala Thr Tyr Ser 
385                 390                 395                 400 


Trp Ser Arg Glu Ser Gly Ala Met Gly Gln Glu Lys Cys Tyr Tyr Ile 
                405                 410                 415     


Thr Ile Phe Ala Ser Ala His Pro Glu Lys Leu Thr Leu Trp Ser Thr 
            420                 425                 430         


Val Leu Ser Thr Tyr His Phe Gly Gly Asn Ala Ser Ala Ala Gly Thr 
        435                 440                 445             


Pro His His Val Ser Val Lys Asn His Ser Leu Asp Ser Val Ser Val 
    450                 455                 460                 


Asp Trp Ala Pro Ser Leu Leu Ser Thr Cys Pro Gly Val Leu Lys Glu 
465                 470                 475                 480 


Tyr Val Val Arg Cys Arg Asp Glu Asp Ser Lys Gln Val Ser Glu His 
                485                 490                 495     


Pro Val Gln Pro Thr Glu Thr Gln Val Thr Leu Ser Gly Leu Arg Ala 
            500                 505                 510         


Gly Val Ala Tyr Thr Val Gln Val Arg Ala Asp Thr Ala Trp Leu Arg 
        515                 520                 525             


Gly Val Trp Ser Gln Pro Gln Arg Phe Ser Ile Glu Val Gln Val Ser 
    530                 535                 540                 


Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu 
545                 550                 555                 560 


Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg Ala Ala Arg His 
                565                 570                 575     


Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe 
            580                 585                 590         


Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln 
        595                 600                 605             


Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu Met Ser Trp Asp 
    610                 615                 620                 


Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro Glu Gly 
625                 630                 635                 640 


Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp Gly Asp 
                645                 650                 655     


Arg Cys Lys Ala Lys Met 
            660         


<210>  3736
<211>  1881
<212>  DNA
<213>  Homosapiens

<400>  3736
ggtggctgaa cctcgcaggt ggcagagagg ctcccctggg gctgtggggc tctacgtgga     60

tccgatggag ccgctggtga cctgggtggt ccccctcctc ttcctcttcc tgctgtccag    120

gcagggcgct gcctgcagaa ccagtgagtg ctgttttcag gacccgccat atccggatgc    180

agactcaggc tcggcctcgg gccctaggga cctgagatgc tatcggatat ccagtgatcg    240

ttacgagtgc tcctggcagt atgagggtcc cacagctggg gtcagccact tcctgcggtg    300

ttgccttagc tccgggcgct gctgctactt cgccgccggc tcagccacca ggctgcagtt    360

ctccgaccag gctggggtgt ctgtgctgta cactgtcaca ctctgggtgg aatcctgggc    420

caggaaccag acagagaagt ctcctgaggt gaccctgcag ctctacaact cagttaaata    480

tgagcctcct ctgggagaca tcaaggtgtc caagttggcc gggcagctgc gtatggagtg    540

ggagaccccg gataaccagg ttggtgctga ggtgcagttc cggcaccgga cacccagcag    600

cccatggaag ttgggcgact gcggacctca ggatgatgat actgagtcct gcctctgccc    660

cctggagatg aatgtggccc aggaattcca gctccgacga cggcagctgg ggagccaagg    720

aagttcctgg agcaagtgga gcagccccgt gtgcgttccc cctgaaaacc ccccacagcc    780

tcaggtgaga ttctcggtgg agcagctggg ccaggatggg aggaggcggc tgaccctgaa    840

agagcagcca acccagctgg agcttccaga aggctgtcaa gggctggcgc ctggcacgga    900

ggtcacttac cgactacagc tccacatgct gtcctgcccg tgtaaggcca aggccaccag    960

gaccctgcac ctggggaaga tgccctatct ctcgggtgct gcctacaacg tggctgtcat   1020

ctcctcgaac caatttggtc ctggcctgaa ccagacgtgg cacattcctg ccgacaccca   1080

cacagatggc atgatctcag ctcactgcaa cctccgcctt ccagattcaa gagattctcc   1140

tgcttcagcc tcccgagtag ctgggattac aggcatctgc caccataccc ggctaatttt   1200

gtatttttag tagagacggg gtttcaccac gttggccagg ctggtctcga actcctgacc   1260

tcaagtgatc cacctgcctt ggcctcccaa agtgttggga ttataggcgt gagccaccat   1320

gcccagccta atttttgtat ttttagtaga gatggagttt caccatgttg cccaggctgg   1380

tctcaaactc ctgccctcag gtgatccacc cacctcagcc tctcaaagtg ctgggattac   1440

aggtgtgagc cactgtggcc gacctactat ttttattatt tttgagctag gttctcagtc   1500

tgttggcaga ctggagtgca atcatggctc actgcagcct tgaactccca gactcaagtg   1560

atccttccac ctcagcctct ggagtagctg ggactacaga catgcaccac cacacctggt   1620

taatttttta tttttatttt ttgtagagac aggtgtctct ctacgttgcc caggctggtc   1680

tcgaactcct gggctcaagt gatccaccca tctccacctc ccaaagtgct aggattacag   1740

gcgtgagcca ccgtacccag cctggtccca tatcatagtg aaatggtgcc tgtaaagctc   1800

tcagcattgg cttggcacat gcagttggta ctcaataaac ggctgttgct atccccaaaa   1860

aaaaaaaaaa aaaaaaaaaa a                                             1881


<210>  3737
<211>  381
<212>  PRT
<213>  Homosapiens

<400>  3737

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Asp Gly Met Ile Ser Ala His Cys Asn Leu Arg Leu 
            340                 345                 350         


Pro Asp Ser Arg Asp Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Ile 
        355                 360                 365             


Thr Gly Ile Cys His His Thr Arg Leu Ile Leu Tyr Phe 
    370                 375                 380     


<210>  3738
<211>  5890
<212>  DNA
<213>  Homosapiens

<400>  3738
atggacgagt cgagcctcct gcggcgccgc gggctccaga aggagctgag cctgccacgc     60

cgaggacgtg gctgccgcag cgggaaccgc aagagcttgg tggtaggaac gccctccccg    120

accctctccc ggcccctgtc gccattgtcg gtcccaacgg caggcagcag ccccttggat    180

agtcctcgga atttctcggc tgcctctgcc ctaaatttcc cctttgcccg gagggcagac    240

ggcagaagat ggtccctcgc gtctctccca tcttccggct atggaaccaa cacacccagc    300

tccaccctct cgtcaagctc atcctcccgg gaacgtctcc accagcttcc cttccagccg    360

acgccggacg agctgcactt cctgtccaag cacttccgca gctcagagaa tgtgcttgat    420

gaggaaggcg gccggtcacc ccgcctccga ccccgctctc gcagtctcag cccgggccgt    480

gcaacgggga ccttcgacaa tgagattgtc atgatgaatc acgtgtaccg ggagaggttc    540

cccaaggcca cagcacagat ggagggccgt ctgcaggagt tcctgacggc ctacgcgccc    600

ggcgcccggc tggcgctggc tgatggcgtc ttgggcttca tccaccacca gatcgtcgag    660

ctggcccgag actgcttggc caagtctggc gagaacctcg tcacctcccg ctacttccta    720

gagatgcagg agaagctgga gcggcttctg caggatgccc atgagcgttc ggacagtgag    780

gaggtcagct tcatcgtcca gcttgtccgg aaactgctga tcatcatctc acggccagct    840

cggctgctgg agtgtctgga gtttgaccct gaggaatttt accacctgct ggaggcggct    900

gagggccatg cgcgggaggg ccaaggcatt aagactgacc ttccacagta catcattggg    960

cagctgggcc tggccaagga ccccctggag gagatggtgc cactgagtca cctcgaagaa   1020

gaacagcccc cagcacctga gtccccagag agccgcgccc tggtcggcca gtcacggagg   1080

aagccatgcg aaagcgactt tgagaccatc aaactcatta gcaacggagc ctatggggcc   1140

gtctacctgg tgcggcaccg tgacacacgg cagcgctttg ccatcaagaa gatcaacaaa   1200

cagaacttga tcctgcgtaa ccagatccag caggtctttg tggagcgtga cattctcacc   1260

tttgccgaga acccctttgt ggtcagcatg ttctgctcct ttgagacccg gcgccaccta   1320

tgtatggtca tggaatacgt ggaaggcggc gactgcgcca cgctcctgaa gaacatgggc   1380

ccgctgcccg tggacatggc ccgcctgtac ttcgccgaga cggtgttggc gctggagtac   1440

ctgcataact atggcatcgt gcaccgtgac ctcaaaccag acaatctgct catcacctcg   1500

cttggccaca tcaagctcac ggacttcggc ctgtccaaga tcggcctcat gagcatggcc   1560

accaacctct atgagggcca catcgagaag gacgcccgag agttcatcga caagcaggtg   1620

tgtgggacgc cggagtacat agcccccgag gtgatcttcc gccagggcta tgggaagcca   1680

gtggactggt gggccatggg cgtcgtcctc tatgagtttc tggtgggctg cgtgcctttc   1740

tttggagata cccccgagga actcttcggt caggtggtca gcgatgagat catgtggcca   1800

gagggagatg aggcccttcc agcagacgcc caggacctca tcaccaggtt gctccggcag   1860

agcccgctgg accgtctggg cactggtggc acccacgaag tgaagcagca cccctttttc   1920

ctggccctgg actgggcagg gcttctccga cacaaagccg agttcgtgcc ccagctcgaa   1980

gctgaggatg ataccagcta ctttgacaca cgttcggaac gttaccgcca tctgggctcc   2040

gaggacgacg agaccaatga tgaagaatcg tccacagaga tcccccagtt ctcctcctgc   2100

tcccaccggt tcagcaaggt ctacagcagc tctgagttcc tggccgtcca gcccactcct   2160

accttcgctg aaaggagctt cagtgaagac cgggaggagg ggtgggagcg cagcgaagtg   2220

gactatggcc gccggctgag tgctgacatc cggctgaggt cctggacatc ctctggatcc   2280

tcctgtcagt catcttcgtc ccagcccgag cggggtccca gcccatctct cctgaatacc   2340

atcagcctgg acacaatgcc caagtttgcc ttctcatcag aggatgaggg ggtaggccca   2400

ggccctgcag gccccaagag gcccgtcttc attctagggg agcctgaccc cccaccagcg   2460

gccaccccag tgatgcccaa gccctcgagc ctttctgccg acacagctgc tctcagccac   2520

gcccgcctac ggagcaatag catcggcgcc cgacactcca caccaaggcc tctggatgcc   2580

ggccggggcc gccgccttgg gggcccaaga gacccagccc ctgagaagtc cagagcctcc   2640

tccagcggtg gcagtggtgg cggcagtggg ggccgcgtgc ccaagtcagc ctctgtctct   2700

gccctgtccc tcatcatcac ggcagatgat ggcagcggcg gccccctcat gagccccctt   2760

tccccgcgct ctctgtcctc gaacccgtcg tcccgtgact cttcgccgag ccgagacccg   2820

tcccccgtgt gtggcagcct gcggcccccc atcgttatcc acagctctgg caagaagtac   2880

ggcttcagcc tgcgggcgat ccgcgtctac atgggtgata gcgacgtcta cactgtgcac   2940

cacgtcgtct ggagtgtgga ggacggaagc cccgcccagg aggcgggcct gcgggctggg   3000

gacctcatca cccacatcaa cggggagtca gtgctggggc tggtgcacat ggacgtcgtg   3060

gagctgctgc tgaagagcgg caacaagata tccctgcgga ccacagccct ggagaacacc   3120

tccatcaagg tgggccccgc ccggaagaat gtggccaagg gccgcatggc acgcaggagc   3180

aagaggagcc gtcggcggga gacccaggat cggcggaagt cacttttcaa gaagatctcc   3240

aagcagacct ccgtgctgca caccagccgc agcttctcct ccggactcca ccactcactg   3300

tcatccagtg agagcctccc cggctcgccc acccacagcc tctcccccag ccccaccact   3360

ccctgccgaa gcccagcccc tgatgtccca gcagatacca ctgcatcccc acccagcgca   3420

tccccgagct ccagcagccc cgcctcccca gctgctgctg gccacacccg ccccagctcc   3480

ctgcacggcc tggctgccaa gcttgggcca ccccgcccca agactggccg ccgcaagtcc   3540

accagcagca tcccgccctc cccgctggcc tgcccgccca tctccgcgcc cccaccccgc   3600

tcgccctcgc ccctgcccgg gcacccgccc gcacctgccc gatccccgcg gctgcgccgg   3660

ggccagtcag ctgacaagct gggcacaggg gagcggctgg atggggaggc ggggcggcgc   3720

actcgtgggc cagaggccga gctcgtggtc atgcggcggc tgcacctgtc cgagcgccga   3780

gactccttca agaagcagga ggccgtgcag gaggttagct tcgatgagcc gcaggaggag   3840

gccactgggc tgcccacctc agtgccacag atcgccgtgg agggcgagga agccgtgcca   3900

gtagctctcg ggcccaccgg aagagactga tcccctgcca ggtctctccc tggcatcaaa   3960

gttacgcgtt ttcttgtgca atgttttttc cgtaaagtca tgcctggatg gggactgagc   4020

caccagcctg acacccagaa ggcgagaagc catctcggtc cttgctggaa ggtggagaca   4080

tcgcttgtgt tctggtgtca atcggggctg gatggggcaa gaatggggga caagggtggc   4140

tttgtaaata gcagcaaatc cctgcaacta atttattact ttttttttct tttttttttt   4200

ttttttttga gacagagtct cactctgttg cccgggctgg agtgcagcgg cgtgatctca   4260

gctcactgca acctccgcct cccaagttca agcgattgtc ctgcctcagc ttcccaagtg   4320

gctgggatta caggcgccca ccactatgcc cagctaattt tttgtatttt tagtacagac   4380

ggggtttcac catgttggtc aggctggtct cgaactcctg acctcatgat ttgcctgcct   4440

ttgcctccca aagtgctggg attacaggcg tgagccactg ggcccagcct aatttattac   4500

tttttataag cgatagccgt actgagccgc cccctgaagg cggctgccag gtcttgcccc   4560

aggcacctgg gactctgttt gcaggccctg ccctctgggc tgagaaggat gcactttgga   4620

caagtcatct gtgtttgtgt tttccagttt ttctgtactt tttaagtgtt ttgtgttacc   4680

tggtctcatt cccctcccca cacctaccca tttgagggga tggagttgaa gtcacctggt   4740

cacctgtacc ggcccagttc ggctacaacc tggagtgtcc gtaaacaatt cctctcaccc   4800

acaaaacaat gtaatcccag cgatggactg gattctgaag gccacttccc accatcatag   4860

ctgccatgcc caggcagtgc ctgctctata tatagagtct gcctccaatc ctgctggctt   4920

cagcctggag aagggatatg ggagctggag ctttgatgga tgaataggtg ttcaccggat   4980

ctgggcagag gggtcatccg ctccccaggt gggcactgat aaaggaaggt acaggcctca   5040

cctggaactg ccaaggcagc ctccagaaat gctcggctgt ctcggggcac gctccagtat   5100

gccagtcctg cgggattacg tccagctact tccagaaaca ctcagtgtcc cctcccctca   5160

ggctctgcct tggcctggcc ttgtccagtc taccctggac aagatgccgt gtgtttgagg   5220

cccagcagag taagcccttg gccgtgatgt gtctgaaaca cctgttaggg gttccctcca   5280

tatgtcagag cctctctggg atgaagttca agccagaaaa cccagtcgag gctcaagttt   5340

gaatttcagc ttcactgtgt ggctctggga aaatggcttt cccactctgt gcctcagttt   5400

ccttgtgttt acaagactaa tcccattgac tgtttattaa gcacctactg tgtgccaagc   5460

gcttttacgt ggcttctccc tcagccagcc ttgagaaggc tggaggtggt gtcatcacct   5520

ccattttaca gacaaagcag ctgagacccc agcgaggggc ggagacctgt cccacgatca   5580

cccagcagga gtcgtggcag aacggagcat cagccagacc ctgttgtggg cgttgtcatc   5640

aagggagctt gaatggaggg tctggtgtca gatacagccg actccagccc cagctcatcc   5700

cccatgatgc tgtgtgaccc actgggcact ctggtgaggg agctttccag acatcaacag   5760

cccactctgc ttccctttct gagtcccctg tccagcactg cctagtgttg gagggtagac   5820

caaggctgtg catgattcac cccctccttc catcctggag ctggcagtga ataaaagccc   5880

gtatttacaa                                                          5890


<210>  3739
<211>  1309
<212>  PRT
<213>  Homosapiens

<400>  3739

Met Asp Glu Ser Ser Leu Leu Arg Arg Arg Gly Leu Gln Lys Glu Leu 
1               5                   10                  15      


Ser Leu Pro Arg Arg Gly Arg Gly Cys Arg Ser Gly Asn Arg Lys Ser 
            20                  25                  30          


Leu Val Val Gly Thr Pro Ser Pro Thr Leu Ser Arg Pro Leu Ser Pro 
        35                  40                  45              


Leu Ser Val Pro Thr Ala Gly Ser Ser Pro Leu Asp Ser Pro Arg Asn 
    50                  55                  60                  


Phe Ser Ala Ala Ser Ala Leu Asn Phe Pro Phe Ala Arg Arg Ala Asp 
65                  70                  75                  80  


Gly Arg Arg Trp Ser Leu Ala Ser Leu Pro Ser Ser Gly Tyr Gly Thr 
                85                  90                  95      


Asn Thr Pro Ser Ser Thr Leu Ser Ser Ser Ser Ser Ser Arg Glu Arg 
            100                 105                 110         


Leu His Gln Leu Pro Phe Gln Pro Thr Pro Asp Glu Leu His Phe Leu 
        115                 120                 125             


Ser Lys His Phe Arg Ser Ser Glu Asn Val Leu Asp Glu Glu Gly Gly 
    130                 135                 140                 


Arg Ser Pro Arg Leu Arg Pro Arg Ser Arg Ser Leu Ser Pro Gly Arg 
145                 150                 155                 160 


Ala Thr Gly Thr Phe Asp Asn Glu Ile Val Met Met Asn His Val Tyr 
                165                 170                 175     


Arg Glu Arg Phe Pro Lys Ala Thr Ala Gln Met Glu Gly Arg Leu Gln 
            180                 185                 190         


Glu Phe Leu Thr Ala Tyr Ala Pro Gly Ala Arg Leu Ala Leu Ala Asp 
        195                 200                 205             


Gly Val Leu Gly Phe Ile His His Gln Ile Val Glu Leu Ala Arg Asp 
    210                 215                 220                 


Cys Leu Ala Lys Ser Gly Glu Asn Leu Val Thr Ser Arg Tyr Phe Leu 
225                 230                 235                 240 


Glu Met Gln Glu Lys Leu Glu Arg Leu Leu Gln Asp Ala His Glu Arg 
                245                 250                 255     


Ser Asp Ser Glu Glu Val Ser Phe Ile Val Gln Leu Val Arg Lys Leu 
            260                 265                 270         


Leu Ile Ile Ile Ser Arg Pro Ala Arg Leu Leu Glu Cys Leu Glu Phe 
        275                 280                 285             


Asp Pro Glu Glu Phe Tyr His Leu Leu Glu Ala Ala Glu Gly His Ala 
    290                 295                 300                 


Arg Glu Gly Gln Gly Ile Lys Thr Asp Leu Pro Gln Tyr Ile Ile Gly 
305                 310                 315                 320 


Gln Leu Gly Leu Ala Lys Asp Pro Leu Glu Glu Met Val Pro Leu Ser 
                325                 330                 335     


His Leu Glu Glu Glu Gln Pro Pro Ala Pro Glu Ser Pro Glu Ser Arg 
            340                 345                 350         


Ala Leu Val Gly Gln Ser Arg Arg Lys Pro Cys Glu Ser Asp Phe Glu 
        355                 360                 365             


Thr Ile Lys Leu Ile Ser Asn Gly Ala Tyr Gly Ala Val Tyr Leu Val 
    370                 375                 380                 


Arg His Arg Asp Thr Arg Gln Arg Phe Ala Ile Lys Lys Ile Asn Lys 
385                 390                 395                 400 


Gln Asn Leu Ile Leu Arg Asn Gln Ile Gln Gln Val Phe Val Glu Arg 
                405                 410                 415     


Asp Ile Leu Thr Phe Ala Glu Asn Pro Phe Val Val Ser Met Phe Cys 
            420                 425                 430         


Ser Phe Glu Thr Arg Arg His Leu Cys Met Val Met Glu Tyr Val Glu 
        435                 440                 445             


Gly Gly Asp Cys Ala Thr Leu Leu Lys Asn Met Gly Pro Leu Pro Val 
    450                 455                 460                 


Asp Met Ala Arg Leu Tyr Phe Ala Glu Thr Val Leu Ala Leu Glu Tyr 
465                 470                 475                 480 


Leu His Asn Tyr Gly Ile Val His Arg Asp Leu Lys Pro Asp Asn Leu 
                485                 490                 495     


Leu Ile Thr Ser Leu Gly His Ile Lys Leu Thr Asp Phe Gly Leu Ser 
            500                 505                 510         


Lys Ile Gly Leu Met Ser Met Ala Thr Asn Leu Tyr Glu Gly His Ile 
        515                 520                 525             


Glu Lys Asp Ala Arg Glu Phe Ile Asp Lys Gln Val Cys Gly Thr Pro 
    530                 535                 540                 


Glu Tyr Ile Ala Pro Glu Val Ile Phe Arg Gln Gly Tyr Gly Lys Pro 
545                 550                 555                 560 


Val Asp Trp Trp Ala Met Gly Val Val Leu Tyr Glu Phe Leu Val Gly 
                565                 570                 575     


Cys Val Pro Phe Phe Gly Asp Thr Pro Glu Glu Leu Phe Gly Gln Val 
            580                 585                 590         


Val Ser Asp Glu Ile Met Trp Pro Glu Gly Asp Glu Ala Leu Pro Ala 
        595                 600                 605             


Asp Ala Gln Asp Leu Ile Thr Arg Leu Leu Arg Gln Ser Pro Leu Asp 
    610                 615                 620                 


Arg Leu Gly Thr Gly Gly Thr His Glu Val Lys Gln His Pro Phe Phe 
625                 630                 635                 640 


Leu Ala Leu Asp Trp Ala Gly Leu Leu Arg His Lys Ala Glu Phe Val 
                645                 650                 655     


Pro Gln Leu Glu Ala Glu Asp Asp Thr Ser Tyr Phe Asp Thr Arg Ser 
            660                 665                 670         


Glu Arg Tyr Arg His Leu Gly Ser Glu Asp Asp Glu Thr Asn Asp Glu 
        675                 680                 685             


Glu Ser Ser Thr Glu Ile Pro Gln Phe Ser Ser Cys Ser His Arg Phe 
    690                 695                 700                 


Ser Lys Val Tyr Ser Ser Ser Glu Phe Leu Ala Val Gln Pro Thr Pro 
705                 710                 715                 720 


Thr Phe Ala Glu Arg Ser Phe Ser Glu Asp Arg Glu Glu Gly Trp Glu 
                725                 730                 735     


Arg Ser Glu Val Asp Tyr Gly Arg Arg Leu Ser Ala Asp Ile Arg Leu 
            740                 745                 750         


Arg Ser Trp Thr Ser Ser Gly Ser Ser Cys Gln Ser Ser Ser Ser Gln 
        755                 760                 765             


Pro Glu Arg Gly Pro Ser Pro Ser Leu Leu Asn Thr Ile Ser Leu Asp 
    770                 775                 780                 


Thr Met Pro Lys Phe Ala Phe Ser Ser Glu Asp Glu Gly Val Gly Pro 
785                 790                 795                 800 


Gly Pro Ala Gly Pro Lys Arg Pro Val Phe Ile Leu Gly Glu Pro Asp 
                805                 810                 815     


Pro Pro Pro Ala Ala Thr Pro Val Met Pro Lys Pro Ser Ser Leu Ser 
            820                 825                 830         


Ala Asp Thr Ala Ala Leu Ser His Ala Arg Leu Arg Ser Asn Ser Ile 
        835                 840                 845             


Gly Ala Arg His Ser Thr Pro Arg Pro Leu Asp Ala Gly Arg Gly Arg 
    850                 855                 860                 


Arg Leu Gly Gly Pro Arg Asp Pro Ala Pro Glu Lys Ser Arg Ala Ser 
865                 870                 875                 880 


Ser Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Arg Val Pro Lys Ser 
                885                 890                 895     


Ala Ser Val Ser Ala Leu Ser Leu Ile Ile Thr Ala Asp Asp Gly Ser 
            900                 905                 910         


Gly Gly Pro Leu Met Ser Pro Leu Ser Pro Arg Ser Leu Ser Ser Asn 
        915                 920                 925             


Pro Ser Ser Arg Asp Ser Ser Pro Ser Arg Asp Pro Ser Pro Val Cys 
    930                 935                 940                 


Gly Ser Leu Arg Pro Pro Ile Val Ile His Ser Ser Gly Lys Lys Tyr 
945                 950                 955                 960 


Gly Phe Ser Leu Arg Ala Ile Arg Val Tyr Met Gly Asp Ser Asp Val 
                965                 970                 975     


Tyr Thr Val His His Val Val Trp Ser Val Glu Asp Gly Ser Pro Ala 
            980                 985                 990         


Gln Glu Ala Gly Leu Arg Ala Gly  Asp Leu Ile Thr His  Ile Asn Gly 
        995                 1000                 1005             


Glu Ser  Val Leu Gly Leu Val  His Met Asp Val Val  Glu Leu Leu 
    1010                 1015                 1020             


Leu Lys  Ser Gly Asn Lys Ile  Ser Leu Arg Thr Thr  Ala Leu Glu 
    1025                 1030                 1035             


Asn Thr  Ser Ile Lys Val Gly  Pro Ala Arg Lys Asn  Val Ala Lys 
    1040                 1045                 1050             


Gly Arg  Met Ala Arg Arg Ser  Lys Arg Ser Arg Arg  Arg Glu Thr 
    1055                 1060                 1065             


Gln Asp  Arg Arg Lys Ser Leu  Phe Lys Lys Ile Ser  Lys Gln Thr 
    1070                 1075                 1080             


Ser Val  Leu His Thr Ser Arg  Ser Phe Ser Ser Gly  Leu His His 
    1085                 1090                 1095             


Ser Leu  Ser Ser Ser Glu Ser  Leu Pro Gly Ser Pro  Thr His Ser 
    1100                 1105                 1110             


Leu Ser  Pro Ser Pro Thr Thr  Pro Cys Arg Ser Pro  Ala Pro Asp 
    1115                 1120                 1125             


Val Pro  Ala Asp Thr Thr Ala  Ser Pro Pro Ser Ala  Ser Pro Ser 
    1130                 1135                 1140             


Ser Ser  Ser Pro Ala Ser Pro  Ala Ala Ala Gly His  Thr Arg Pro 
    1145                 1150                 1155             


Ser Ser  Leu His Gly Leu Ala  Ala Lys Leu Gly Pro  Pro Arg Pro 
    1160                 1165                 1170             


Lys Thr  Gly Arg Arg Lys Ser  Thr Ser Ser Ile Pro  Pro Ser Pro 
    1175                 1180                 1185             


Leu Ala  Cys Pro Pro Ile Ser  Ala Pro Pro Pro Arg  Ser Pro Ser 
    1190                 1195                 1200             


Pro Leu  Pro Gly His Pro Pro  Ala Pro Ala Arg Ser  Pro Arg Leu 
    1205                 1210                 1215             


Arg Arg  Gly Gln Ser Ala Asp  Lys Leu Gly Thr Gly  Glu Arg Leu 
    1220                 1225                 1230             


Asp Gly  Glu Ala Gly Arg Arg  Thr Arg Gly Pro Glu  Ala Glu Leu 
    1235                 1240                 1245             


Val Val  Met Arg Arg Leu His  Leu Ser Glu Arg Arg  Asp Ser Phe 
    1250                 1255                 1260             


Lys Lys  Gln Glu Ala Val Gln  Glu Val Ser Phe Asp  Glu Pro Gln 
    1265                 1270                 1275             


Glu Glu  Ala Thr Gly Leu Pro  Thr Ser Val Pro Gln  Ile Ala Val 
    1280                 1285                 1290             


Glu Gly  Glu Glu Ala Val Pro  Val Ala Leu Gly Pro  Thr Gly Arg 
    1295                 1300                 1305             


Asp 
    


<210>  3740
<211>  4935
<212>  DNA
<213>  Homosapiens

<400>  3740
gtctggagaa gagagtttcc acgttgtcat cataggatct ggactcaagt gaccaaaacc     60

ttgcttggat ttttacctga tgaagtttgt cttgaaaagt gaaaatggtt ccatttccat    120

tttccctgtt ctcaagggat ggaagaagcg agcctgtgcc ttggagtgtc ttcggcggag    180

ccggaagctg agccccacct gagtggcccc gtcctcaacg gccagtatgc catgagtcag    240

aagctgcacc agatcacctc ccagctcagc catgccttcc ccgagctcca tccccggccc    300

aaccccgagg agaagccccc cgcatccctg gaggagaagg cccacgtgcc catgagcggc    360

cagcccatgg gcagtcagat ggcgctcctg gccaaccagc tgggccggga ggtggacacc    420

agcctcaacg ggagggtgga cttgcagcag ttcctcaacg ggcagaacct gggcatcatg    480

tcccagatga gcgacatcga ggacgacgcc cgcaagaacc gcaagtaccc gtgcccactc    540

tgcggcaagc gcttccgctt caacagcatc ctctccctgc acatgcgcac gcacacgggc    600

gagaagccct tcaagtgccc gtactgcgac cacagggcgg cgcagaaggg gaacctcaag    660

attcacctgc ggacccacaa gctgggcaac ctgggcaagg ggcgtgggcg tgtgcgcgag    720

gagaaccgcc tgctgcacga gctggaggag cgcgccatcc tgcgggacaa gcagctgaaa    780

ggcagcctgc tgcagccccg gccggacctg aagcccccgc cgcacgccca gcaggccccg    840

ctggccgcct gcaccctggc cctgcaggct aaccacagcg ttcccgacgt ggcccacccg    900

gtgccctcgc ccaagcctgc cagcgtgcag gaggacgcgg tggccccggc ggcgggcttc    960

cgctgtacct tctgcaaggg caagttcaag aagcgcgagg agctggaccg ccacatccgc   1020

atcttgcaca agccctacaa gtgcacgttg tgcgacttcg cggcttcgca ggaggaggag   1080

ctcatcagcc acgtggagaa ggcacacatc acggccgagt cggcccaggg ccagggcccc   1140

aacggcggtg gcgagcagtc ggccaacgag ttccgctgcg aggtgtgcgg tcaggtgttc   1200

agccaggcgt ggttcctcaa gggtcacatg cgcaagcaca aagactcctt tgagcactgc   1260

tgccagatct gcggccggcg cttcaaggag ccctggttcc tcaagaacca catgaaggtc   1320

cacctcaaca agctgtcggt gaagaacaag tcccccagcg accccgaggt gcctgtgccc   1380

atgggcggca tgtcccagga ggcccacgcc aacctgtact ccaggtacct ctcctgcctg   1440

cagagtggct tcatgacccc ggacaaagcc ggcctgagcg agcccagcca gctctatggc   1500

aagggcgagc tgcccatgaa ggagaaggaa gcgctgggga agctgctgtc tcccatctcc   1560

agcatggccc acggcgtccc ggagggggac aagcactccc tcctgggatg cctcaatctc   1620

gtgccgccgc tgaaatccag ctgcatcgag cggctgcagg cggctgccaa ggctgcggag   1680

atggaccccg tgaacagcta ccaggcttgg cagctcatgg ccaggggcat ggccatggaa   1740

catggcttct tgtctaaaga gcatccgctg cagcgcaacc acgaagacac tttggcaaac   1800

gccggggttc tgtttgataa ggagaagcgg gagtacgtgt tagtgggagc agatggctcc   1860

aagcagaaaa tgcctgctga tttggttcac agcactaaag tgggcagcca gagagacctg   1920

ccaagtaagc tcgacccttt agaaagcagt cgggattttt tgtcacacgg gctgaaccag   1980

actctcgagt ataacctgca gggtcctggg aacatgaagg agaagcccac cgagtgcccc   2040

gactgcggcc gggtgttccg cacttaccac caggtggtcg tgcactcccg tgtccacaag   2100

cgggaccgca agggcgagga ggatgggctg cacgtgggcc tggatgagcg gcgtggctcg   2160

ggcagtgacc aggagtccca gtcggtgagc cgctccacca cgccgggctc ctctaacgtc   2220

accgaggaga gcggggtcgg aggcggcctc tcccagaccg ggagtgccca ggaggacagc   2280

ccgcacccct cctcgccatc ctcctcagac attggcgagg aggctgggag atctgccggc   2340

gtccagcaac cagcgctgct tcgcgacaga agcctgggct cggccatgaa ggactgcccg   2400

tactgtggga aaactttccg gacatcccat caccttaagg tgcacctgag gatacacaca   2460

ggtgagaaac cctacaagtg tccgcactgt gactatgccg gcacgcagtc agcatcctta   2520

aaataccact tagagcgaca ccatcgggag cggcagaacg gggctgggcc gctgtctggg   2580

caacccccaa atcaagacca caaggatgag atgtcaagca aagcttctct gttcatcagg   2640

ccagacatcc tgaggggggc cttcaagggt ctccctggaa tcgacttcag aggaggccct   2700

gcatctcagc agtggacatc aggggttctc tcctctggag atcactcggg gcaggccacg   2760

ggcatgtctt cggaggtccc ctcagatgct ctgaaaggca ctgaccttcc ttccaaaagc   2820

acccacttct ctgagatcgg aagagcttat caaagcattg tgagcaacgg tgtgaatttc   2880

caagggtcct tgcaagcttt catggacagt tttgtcctca gttccttgaa gaaggagaag   2940

gacatgaagg acaaagccct ggctgacccc ccttccatga aagtccacgg agtggatggt   3000

ggtgaggaga aacccagtgg caagtcctcc cagaggaagt ccgagaaatc tcagtatgaa   3060

cccctggact tgtctgtgcg gccagatgcc gcctccctcc cgggctcctc ggtaactgtg   3120

caggacagca ttgcatggca cggctgcttg ttttgtgctt tcacaacgtc ctccatggag   3180

ctcatggccc ttcatctcca ggccaaccac ctgggcaaag cgaaacgcaa agataacacc   3240

atcggggtca cagtcaactg caaagaccaa gcccgggagg cgagtaagat ggccctgctg   3300

ccctcgttac aatcaaacaa agacctgggc ctctccaata tgatcagctc tctagactct   3360

gcttctgaga agatggccca aggtcagctc aaggagactc tgggagagca gaagagcggt   3420

gcatggaccg gccacgtgga ccctgcattt tgtaacttcc catcagactt ctacaagcag   3480

tttggtgttt acccaggcat ggttggctca ggggcctcca gttcctgccc caacaaggag   3540

cctgatggaa aggcccactc tgaagaggat gtccccatcc tgatccccga aaccacgagt   3600

aagaacacta ctgatgacct ctctgacatt gcctcctcag aggacatgga ctcctccaag   3660

ggggagaaca acgatgaaga ggatgttgaa accgaaccgg aaatgatgac caagccactg   3720

tctgccctca gcaaagacag cagcagcgat ggcggggaca gcctgcagcc cacaggcacc   3780

tcccagcccg tccagggact ggtctcacct ttatcccaag caccggagaa gcagtggcac   3840

agccagggtc ttctccaagc ccaggacccc ttggcgggcc tgccaaagcc ggagcggggg   3900

ccccagagcc tggacaagcc gatgaacatg ctgtcggtcc tcagggccta cagttctgat   3960

ggcttagcag cctttaacgg acttgcaagt agcacagcaa attctggatg tatcaagagg   4020

ccagacttgt gtggtaagtg acactccctg tcctagtcgg tctatctgga cttgcccttg   4080

tctgttcgtg gtcctcggtg gttatctgca gcttgttaat cgtgtaaagt caagagaaga   4140

atgtatacac atatgtgtgt tgaataatta ctattggcat aggtatgtgt atacacacgg   4200

tgcaccaatc tacagtatat atagcagaga atcagaggct aaaaatatta ccccatatgt   4260

tccagtatta gtcatggatt gcaaaggctt agtaacttga gcaggagaga aaactccctc   4320

aaagtcataa atcctgagtg acaactgctg ctggatgaca gatcccttca cctgtggaca   4380

acctggctgg gggtgggggg ctgttccacc agctcacctg agcatgtaga ggtgggtcct   4440

gcagtggtct cgtgggtatt actgcttgtg tctgattgtc ctgtattttg taacacttta   4500

gaagaataca gaaaagtgca gtaattctct ttctccatag tatttaagca gaaatattgc   4560

tagtttaata ttgtgtcagg tcgtcctatt aaccaggagc agatgacagt aaaatttcag   4620

tgaatagcac cttgacatct acaacttaaa aatggtgatt gaagcaaaat atgtaaactt   4680

gtacggggtg atcgtgtgct ttggaacaga gtattgttga agtaattaga agatatatta   4740

aggtgttcct ggtaatgaag gcatgtaagt tataataatt gtagctttct gaataagtgt   4800

caaactatat ctttaagtgt gctgtatgct gagttacaag ttaggtcatt tatgaatgga   4860

atgtaaaata atactaaaaa tgcttcaata acttatcttg gtattgctaa taaaaaaaaa   4920

aagctgtgaa acatt                                                    4935


<210>  3741
<211>  1300
<212>  PRT
<213>  Homosapiens

<400>  3741

Met Glu Glu Ala Ser Leu Cys Leu Gly Val Ser Ser Ala Glu Pro Glu 
1               5                   10                  15      


Ala Glu Pro His Leu Ser Gly Pro Val Leu Asn Gly Gln Tyr Ala Met 
            20                  25                  30          


Ser Gln Lys Leu His Gln Ile Thr Ser Gln Leu Ser His Ala Phe Pro 
        35                  40                  45              


Glu Leu His Pro Arg Pro Asn Pro Glu Glu Lys Pro Pro Ala Ser Leu 
    50                  55                  60                  


Glu Glu Lys Ala His Val Pro Met Ser Gly Gln Pro Met Gly Ser Gln 
65                  70                  75                  80  


Met Ala Leu Leu Ala Asn Gln Leu Gly Arg Glu Val Asp Thr Ser Leu 
                85                  90                  95      


Asn Gly Arg Val Asp Leu Gln Gln Phe Leu Asn Gly Gln Asn Leu Gly 
            100                 105                 110         


Ile Met Ser Gln Met Ser Asp Ile Glu Asp Asp Ala Arg Lys Asn Arg 
        115                 120                 125             


Lys Tyr Pro Cys Pro Leu Cys Gly Lys Arg Phe Arg Phe Asn Ser Ile 
    130                 135                 140                 


Leu Ser Leu His Met Arg Thr His Thr Gly Glu Lys Pro Phe Lys Cys 
145                 150                 155                 160 


Pro Tyr Cys Asp His Arg Ala Ala Gln Lys Gly Asn Leu Lys Ile His 
                165                 170                 175     


Leu Arg Thr His Lys Leu Gly Asn Leu Gly Lys Gly Arg Gly Arg Val 
            180                 185                 190         


Arg Glu Glu Asn Arg Leu Leu His Glu Leu Glu Glu Arg Ala Ile Leu 
        195                 200                 205             


Arg Asp Lys Gln Leu Lys Gly Ser Leu Leu Gln Pro Arg Pro Asp Leu 
    210                 215                 220                 


Lys Pro Pro Pro His Ala Gln Gln Ala Pro Leu Ala Ala Cys Thr Leu 
225                 230                 235                 240 


Ala Leu Gln Ala Asn His Ser Val Pro Asp Val Ala His Pro Val Pro 
                245                 250                 255     


Ser Pro Lys Pro Ala Ser Val Gln Glu Asp Ala Val Ala Pro Ala Ala 
            260                 265                 270         


Gly Phe Arg Cys Thr Phe Cys Lys Gly Lys Phe Lys Lys Arg Glu Glu 
        275                 280                 285             


Leu Asp Arg His Ile Arg Ile Leu His Lys Pro Tyr Lys Cys Thr Leu 
    290                 295                 300                 


Cys Asp Phe Ala Ala Ser Gln Glu Glu Glu Leu Ile Ser His Val Glu 
305                 310                 315                 320 


Lys Ala His Ile Thr Ala Glu Ser Ala Gln Gly Gln Gly Pro Asn Gly 
                325                 330                 335     


Gly Gly Glu Gln Ser Ala Asn Glu Phe Arg Cys Glu Val Cys Gly Gln 
            340                 345                 350         


Val Phe Ser Gln Ala Trp Phe Leu Lys Gly His Met Arg Lys His Lys 
        355                 360                 365             


Asp Ser Phe Glu His Cys Cys Gln Ile Cys Gly Arg Arg Phe Lys Glu 
    370                 375                 380                 


Pro Trp Phe Leu Lys Asn His Met Lys Val His Leu Asn Lys Leu Ser 
385                 390                 395                 400 


Val Lys Asn Lys Ser Pro Ser Asp Pro Glu Val Pro Val Pro Met Gly 
                405                 410                 415     


Gly Met Ser Gln Glu Ala His Ala Asn Leu Tyr Ser Arg Tyr Leu Ser 
            420                 425                 430         


Cys Leu Gln Ser Gly Phe Met Thr Pro Asp Lys Ala Gly Leu Ser Glu 
        435                 440                 445             


Pro Ser Gln Leu Tyr Gly Lys Gly Glu Leu Pro Met Lys Glu Lys Glu 
    450                 455                 460                 


Ala Leu Gly Lys Leu Leu Ser Pro Ile Ser Ser Met Ala His Gly Val 
465                 470                 475                 480 


Pro Glu Gly Asp Lys His Ser Leu Leu Gly Cys Leu Asn Leu Val Pro 
                485                 490                 495     


Pro Leu Lys Ser Ser Cys Ile Glu Arg Leu Gln Ala Ala Ala Lys Ala 
            500                 505                 510         


Ala Glu Met Asp Pro Val Asn Ser Tyr Gln Ala Trp Gln Leu Met Ala 
        515                 520                 525             


Arg Gly Met Ala Met Glu His Gly Phe Leu Ser Lys Glu His Pro Leu 
    530                 535                 540                 


Gln Arg Asn His Glu Asp Thr Leu Ala Asn Ala Gly Val Leu Phe Asp 
545                 550                 555                 560 


Lys Glu Lys Arg Glu Tyr Val Leu Val Gly Ala Asp Gly Ser Lys Gln 
                565                 570                 575     


Lys Met Pro Ala Asp Leu Val His Ser Thr Lys Val Gly Ser Gln Arg 
            580                 585                 590         


Asp Leu Pro Ser Lys Leu Asp Pro Leu Glu Ser Ser Arg Asp Phe Leu 
        595                 600                 605             


Ser His Gly Leu Asn Gln Thr Leu Glu Tyr Asn Leu Gln Gly Pro Gly 
    610                 615                 620                 


Asn Met Lys Glu Lys Pro Thr Glu Cys Pro Asp Cys Gly Arg Val Phe 
625                 630                 635                 640 


Arg Thr Tyr His Gln Val Val Val His Ser Arg Val His Lys Arg Asp 
                645                 650                 655     


Arg Lys Gly Glu Glu Asp Gly Leu His Val Gly Leu Asp Glu Arg Arg 
            660                 665                 670         


Gly Ser Gly Ser Asp Gln Glu Ser Gln Ser Val Ser Arg Ser Thr Thr 
        675                 680                 685             


Pro Gly Ser Ser Asn Val Thr Glu Glu Ser Gly Val Gly Gly Gly Leu 
    690                 695                 700                 


Ser Gln Thr Gly Ser Ala Gln Glu Asp Ser Pro His Pro Ser Ser Pro 
705                 710                 715                 720 


Ser Ser Ser Asp Ile Gly Glu Glu Ala Gly Arg Ser Ala Gly Val Gln 
                725                 730                 735     


Gln Pro Ala Leu Leu Arg Asp Arg Ser Leu Gly Ser Ala Met Lys Asp 
            740                 745                 750         


Cys Pro Tyr Cys Gly Lys Thr Phe Arg Thr Ser His His Leu Lys Val 
        755                 760                 765             


His Leu Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Pro His Cys 
    770                 775                 780                 


Asp Tyr Ala Gly Thr Gln Ser Ala Ser Leu Lys Tyr His Leu Glu Arg 
785                 790                 795                 800 


His His Arg Glu Arg Gln Asn Gly Ala Gly Pro Leu Ser Gly Gln Pro 
                805                 810                 815     


Pro Asn Gln Asp His Lys Asp Glu Met Ser Ser Lys Ala Ser Leu Phe 
            820                 825                 830         


Ile Arg Pro Asp Ile Leu Arg Gly Ala Phe Lys Gly Leu Pro Gly Ile 
        835                 840                 845             


Asp Phe Arg Gly Gly Pro Ala Ser Gln Gln Trp Thr Ser Gly Val Leu 
    850                 855                 860                 


Ser Ser Gly Asp His Ser Gly Gln Ala Thr Gly Met Ser Ser Glu Val 
865                 870                 875                 880 


Pro Ser Asp Ala Leu Lys Gly Thr Asp Leu Pro Ser Lys Ser Thr His 
                885                 890                 895     


Phe Ser Glu Ile Gly Arg Ala Tyr Gln Ser Ile Val Ser Asn Gly Val 
            900                 905                 910         


Asn Phe Gln Gly Ser Leu Gln Ala Phe Met Asp Ser Phe Val Leu Ser 
        915                 920                 925             


Ser Leu Lys Lys Glu Lys Asp Met Lys Asp Lys Ala Leu Ala Asp Pro 
    930                 935                 940                 


Pro Ser Met Lys Val His Gly Val Asp Gly Gly Glu Glu Lys Pro Ser 
945                 950                 955                 960 


Gly Lys Ser Ser Gln Arg Lys Ser Glu Lys Ser Gln Tyr Glu Pro Leu 
                965                 970                 975     


Asp Leu Ser Val Arg Pro Asp Ala Ala Ser Leu Pro Gly Ser Ser Val 
            980                 985                 990         


Thr Val Gln Asp Ser Ile Ala Trp  His Gly Cys Leu Phe  Cys Ala Phe 
        995                 1000                 1005             


Thr Thr  Ser Ser Met Glu Leu  Met Ala Leu His Leu  Gln Ala Asn 
    1010                 1015                 1020             


His Leu  Gly Lys Ala Lys Arg  Lys Asp Asn Thr Ile  Gly Val Thr 
    1025                 1030                 1035             


Val Asn  Cys Lys Asp Gln Ala  Arg Glu Ala Ser Lys  Met Ala Leu 
    1040                 1045                 1050             


Leu Pro  Ser Leu Gln Ser Asn  Lys Asp Leu Gly Leu  Ser Asn Met 
    1055                 1060                 1065             


Ile Ser  Ser Leu Asp Ser Ala  Ser Glu Lys Met Ala  Gln Gly Gln 
    1070                 1075                 1080             


Leu Lys  Glu Thr Leu Gly Glu  Gln Lys Ser Gly Ala  Trp Thr Gly 
    1085                 1090                 1095             


His Val  Asp Pro Ala Phe Cys  Asn Phe Pro Ser Asp  Phe Tyr Lys 
    1100                 1105                 1110             


Gln Phe  Gly Val Tyr Pro Gly  Met Val Gly Ser Gly  Ala Ser Ser 
    1115                 1120                 1125             


Ser Cys  Pro Asn Lys Glu Pro  Asp Gly Lys Ala His  Ser Glu Glu 
    1130                 1135                 1140             


Asp Val  Pro Ile Leu Ile Pro  Glu Thr Thr Ser Lys  Asn Thr Thr 
    1145                 1150                 1155             


Asp Asp  Leu Ser Asp Ile Ala  Ser Ser Glu Asp Met  Asp Ser Ser 
    1160                 1165                 1170             


Lys Gly  Glu Asn Asn Asp Glu  Glu Asp Val Glu Thr  Glu Pro Glu 
    1175                 1180                 1185             


Met Met  Thr Lys Pro Leu Ser  Ala Leu Ser Lys Asp  Ser Ser Ser 
    1190                 1195                 1200             


Asp Gly  Gly Asp Ser Leu Gln  Pro Thr Gly Thr Ser  Gln Pro Val 
    1205                 1210                 1215             


Gln Gly  Leu Val Ser Pro Leu  Ser Gln Ala Pro Glu  Lys Gln Trp 
    1220                 1225                 1230             


His Ser  Gln Gly Leu Leu Gln  Ala Gln Asp Pro Leu  Ala Gly Leu 
    1235                 1240                 1245             


Pro Lys  Pro Glu Arg Gly Pro  Gln Ser Leu Asp Lys  Pro Met Asn 
    1250                 1255                 1260             


Met Leu  Ser Val Leu Arg Ala  Tyr Ser Ser Asp Gly  Leu Ala Ala 
    1265                 1270                 1275             


Phe Asn  Gly Leu Ala Ser Ser  Thr Ala Asn Ser Gly  Cys Ile Lys 
    1280                 1285                 1290             


Arg Pro  Asp Leu Cys Gly Lys  
    1295                 1300 


<210>  3742
<211>  3265
<212>  DNA
<213>  Homosapiens

<400>  3742
aggcttcgtc cgccgttagg ttgcggctgc tgtggttgcc aacgctacac tgggtagaac     60

gccagacagg ggccactttt cgagaccgag tagagacgga cagtgaggag gataggaccc    120

acttacacgc ttttatgtca gccgcgatcc aacccccaca agcgtctgca aaacccttcc    180

tggggccttg gcgacagccc tgtgtcctca cggcgcgcag aggcggcgcc gcgaaccttg    240

tgtgcatttt acacgacggc ggggactgag gtccctcgca gcccagagcc ggagcccggg    300

gtcggccgag cccgcaggac cggcttcctc gccgactctc acggcctcac ccagccccct    360

gggcccatgg cggcgccggc gttgtgctcg gagagcatca ctctaggtgc cgtctttgaa    420

gaaggactct ctaggtcctg ctgttgtttt aggggatcat tccagcggaa gtctggccct    480

accaaaagct gggagaggga atgagagcct cgagggcaag aggcattagt atcatttgaa    540

gacgtggttg tgaccttcac tggagaggaa tgggggcacc tggacctggc ccagaggacc    600

ctgtaccagg aggtaatgct ggagacctgc aggctcctgg tctcactggg gcatcctgtt    660

cccaaaccag agctgatcta tctactggaa catggacagg aactgtggac agtgaagaga    720

ggcctctccc aaagcacctg cgcaggtgaa aaagcaaaac ccaagattac agagcctact    780

gcttctcagc tggccttctc tgaggaatcc tctttccagg aacttctggc acagagatcc    840

tcaagagatt ccaggttggg gcaagctaga gatgaggaaa agctaataaa aattcaggaa    900

gggaacttga ggccaggaac aaacccccac aaagagatat gccctgagaa gttgagttat    960

aaacatgatg atttggagcc agatgatagt ctgggcttaa gggttttaca ggaacgagtc   1020

actccacaag atgctctcca tgagtgtgac tctcaaggac caggaaaaga ccccatgact   1080

gatgcaagga ataaccctta cacatgcacg gaatgtggga aagggtttag caagaagtgg   1140

gcccttgttc ggcatcaaca gattcatgct ggagtgaagc cctatgagtg caatgagtgt   1200

gggaaagcct gtcgttatat ggctgatgtc attcgacata tgaggcttca tactggggaa   1260

aaaccataca agtgtattga gtgtgggaaa gccttcaaac gcaggtttca cctcacggag   1320

caccagcgta ttcacaccgg agataagccc tatgagtgca aagaatgtgg caaagcattc   1380

acccaccgct cttcttttat ccagcataat atgactcaca ctcgagaaaa acccttttta   1440

tgcaaagaat gtgggaaagc tttttactac agctcctcat ttgctcaaca tatgaggatt   1500

catactggaa agaaactcta tgagtgcggt gaatgtggaa aggccttcac gcaccgctcc   1560

acatttatcc agcacaatgt gacccacaca ggagaaaaac catttttatg taaagaatgt   1620

ggaaaaacct tttgcctcaa ctcatccttc actcagcaca tgaggattca cactggagag   1680

aaaccctatg agtgcggtga atgtggaaag gcctttactc atcgctccac tttcatccga   1740

cataagagga cccataccgg agagaagccc tttgagtgca aagaatgtgg gaaggccttt   1800

tgtgacagct cttccttaat tcaacatatg aggattcaca ctggtgagaa gccttatgag   1860

tgcagtgaat gtggaaagac ttttacacac cactctgttt ttattcgaca taataggacc   1920

cacagtggac aaaaaccctt ggagtgcaaa gaatgtgcaa aagcctttta ctatagctct   1980

tccttcactc gacacatgag gattcacact ggagagaagc cctatgtttg tagagaatgt   2040

ggaaaggctt ttacccaacc tgcaaatttt gttcggcata ataggatcca cactggagaa   2100

aaaccttttg aatgcaaaga atgtgagaaa gccttctgtg acaactttgc tttaactcag   2160

cacatgagaa ctcacactgg agagaaaccc tttgaatgca atgaatgtgg aaagaccttc   2220

agccacagtt catcgttcac tcaccatcga aagattcata ccagagttta aaagatacag   2280

gaaggcctat tacaagtgtg tttgtcttta gtgaactcat agtggtgaca tacctttcct   2340

tttgagtata actattgagg gaaatatttt ggccagagag atgtcttagt atctgataat   2400

ttatactaac tagaaacaga attgtccctg tgaaatcttt ttatggcagg taatcacttg   2460

tcatccaaag aattatatta aagattcacc cagtttagag ccttacactg tacctgagaa   2520

taatcgaggg gagagacctg gtggttaaca tgcatttagg taaaatgtca ggaacaactt   2580

tcctcttatt aatactataa atccatctca agcatatttt aaaataatga gagatggagg   2640

aaacaatcta gaagataaaa gaaaaagatg tgcataactt gttttcagtt tccctgttta   2700

tgacagtttg tcatttggcg ggttggggga tggagcaggg aataagacat tgaaaaagtc   2760

tcatcccctt tgtgtgtttt acatatatat atctctaagt ccagagccag gagagttgga   2820

ccattgaggg cagctctgcc aacatttagt aaaagtattc attgttccaa aactgtcatc   2880

tctacccttg agggagtgtg tctttgtgag aaatataaag gcttgagtca tgaaatactt   2940

aacacatgtg cacatgtaca catgtacatt tatatgcagt gaattgttac tcgtggtagt   3000

taggttctgt gaattttctg tgcacactga attagtgaat gctgaatgat tgttgctagg   3060

ggaaatacag cgttagcttc tgtgagcctc tgatccaaac atttttatca accagtcaac   3120

acataacctt cttctatggg tatttgtttg tttgtttgtt taaagacact ttatcagtgt   3180

ttcttgaata attataatta ttctttataa taaaaatatt ttaattataa aaaaaaaaaa   3240

aaaaaaaaca aaaaaaaaaa aaaaa                                         3265


<210>  3743
<211>  551
<212>  PRT
<213>  Homosapiens

<400>  3743

Met Leu Glu Thr Cys Arg Leu Leu Val Ser Leu Gly His Pro Val Pro 
1               5                   10                  15      


Lys Pro Glu Leu Ile Tyr Leu Leu Glu His Gly Gln Glu Leu Trp Thr 
            20                  25                  30          


Val Lys Arg Gly Leu Ser Gln Ser Thr Cys Ala Gly Glu Lys Ala Lys 
        35                  40                  45              


Pro Lys Ile Thr Glu Pro Thr Ala Ser Gln Leu Ala Phe Ser Glu Glu 
    50                  55                  60                  


Ser Ser Phe Gln Glu Leu Leu Ala Gln Arg Ser Ser Arg Asp Ser Arg 
65                  70                  75                  80  


Leu Gly Gln Ala Arg Asp Glu Glu Lys Leu Ile Lys Ile Gln Glu Gly 
                85                  90                  95      


Asn Leu Arg Pro Gly Thr Asn Pro His Lys Glu Ile Cys Pro Glu Lys 
            100                 105                 110         


Leu Ser Tyr Lys His Asp Asp Leu Glu Pro Asp Asp Ser Leu Gly Leu 
        115                 120                 125             


Arg Val Leu Gln Glu Arg Val Thr Pro Gln Asp Ala Leu His Glu Cys 
    130                 135                 140                 


Asp Ser Gln Gly Pro Gly Lys Asp Pro Met Thr Asp Ala Arg Asn Asn 
145                 150                 155                 160 


Pro Tyr Thr Cys Thr Glu Cys Gly Lys Gly Phe Ser Lys Lys Trp Ala 
                165                 170                 175     


Leu Val Arg His Gln Gln Ile His Ala Gly Val Lys Pro Tyr Glu Cys 
            180                 185                 190         


Asn Glu Cys Gly Lys Ala Cys Arg Tyr Met Ala Asp Val Ile Arg His 
        195                 200                 205             


Met Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Ile Glu Cys Gly 
    210                 215                 220                 


Lys Ala Phe Lys Arg Arg Phe His Leu Thr Glu His Gln Arg Ile His 
225                 230                 235                 240 


Thr Gly Asp Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Thr 
                245                 250                 255     


His Arg Ser Ser Phe Ile Gln His Asn Met Thr His Thr Arg Glu Lys 
            260                 265                 270         


Pro Phe Leu Cys Lys Glu Cys Gly Lys Ala Phe Tyr Tyr Ser Ser Ser 
        275                 280                 285             


Phe Ala Gln His Met Arg Ile His Thr Gly Lys Lys Leu Tyr Glu Cys 
    290                 295                 300                 


Gly Glu Cys Gly Lys Ala Phe Thr His Arg Ser Thr Phe Ile Gln His 
305                 310                 315                 320 


Asn Val Thr His Thr Gly Glu Lys Pro Phe Leu Cys Lys Glu Cys Gly 
                325                 330                 335     


Lys Thr Phe Cys Leu Asn Ser Ser Phe Thr Gln His Met Arg Ile His 
            340                 345                 350         


Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu Cys Gly Lys Ala Phe Thr 
        355                 360                 365             


His Arg Ser Thr Phe Ile Arg His Lys Arg Thr His Thr Gly Glu Lys 
    370                 375                 380                 


Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe Cys Asp Ser Ser Ser 
385                 390                 395                 400 


Leu Ile Gln His Met Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
                405                 410                 415     


Ser Glu Cys Gly Lys Thr Phe Thr His His Ser Val Phe Ile Arg His 
            420                 425                 430         


Asn Arg Thr His Ser Gly Gln Lys Pro Leu Glu Cys Lys Glu Cys Ala 
        435                 440                 445             


Lys Ala Phe Tyr Tyr Ser Ser Ser Phe Thr Arg His Met Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys Gly Lys Ala Phe Thr 
465                 470                 475                 480 


Gln Pro Ala Asn Phe Val Arg His Asn Arg Ile His Thr Gly Glu Lys 
                485                 490                 495     


Pro Phe Glu Cys Lys Glu Cys Glu Lys Ala Phe Cys Asp Asn Phe Ala 
            500                 505                 510         


Leu Thr Gln His Met Arg Thr His Thr Gly Glu Lys Pro Phe Glu Cys 
        515                 520                 525             


Asn Glu Cys Gly Lys Thr Phe Ser His Ser Ser Ser Phe Thr His His 
    530                 535                 540                 


Arg Lys Ile His Thr Arg Val 
545                 550     


<210>  3744
<211>  3101
<212>  DNA
<213>  Homosapiens

<400>  3744
cggcgtccag tcttcgtccg ccgttaggtt gcggctgctg tggttgccaa cgctacactg     60

ggtagaacgc cagacagggg ccacttttcg agaccgagta gagacggaca gtgaggagga    120

taggacccac ttacacgctt ttatgtcagc cgcgatccca cccccacaag cgtctgcaaa    180

acccttcctg gggccttggc gacagccctg tgtcctcacg gcgcgcagag gcggcgccgc    240

gaaccttgtg tgcattttac acgacggcgg ggactgaggt ccctcgcagc ccagagccgg    300

agcccggggt cggccgagcc cgcaggaccg gcttcctcgc cgactctcac ggcctcaccc    360

agccccctgg gcccatggcg gcgccggcgt tggcattagt atcatttgaa gacgtggttg    420

tgaccttcac tggagaggaa tgggggcacc tggacctggc ccagaggacc ctgtaccagg    480

aggtgatgct ggagacctgc aggctcctgg tctcactggg gcatcctgtt cccaaaccag    540

agctgatcta tctactggaa catggacagg aactgtggac agtgaagaga ggcctctccc    600

aaagcacctg cgcaggtgaa aaagcaaaac ccaagattac agagcctact gcttctcagc    660

tggccttctc tgaggaatcc tctttccagg aacttctggc acagagatcc tcaagagatt    720

ccaggttggg gcaagctaga gatgaggaaa agctaataaa aattcaggaa gggaacttga    780

ggccaggaac aaacccccac aaagagatat gccctgagaa gttgagttat aaacatgatg    840

atttggagcc agatgatagt ctgggcttaa gggttttaca ggaacgagtc actccacaag    900

atgctctcca tgagtgtgac tctcaaggac caggaaaaga ccccatgact gatgcaagga    960

ataaccctta cacatgcacg gaatgtggga aagggtttag caagaagtgg gcccttgttc   1020

ggcatcaaca gattcatgct ggagtgaagc cctatgagtg caatgagtgt gggaaagcct   1080

gtcgttatat ggctgatgtc attcgacata tgaggcttca tactggggaa aaaccataca   1140

agtgtattga gtgtgggaaa gccttcaaac gcaggtttca cctcacggag caccagcgta   1200

ttcacaccgg agataagccc tatgagtgca aagaatgtgg caaagcattc acccaccgct   1260

cttcttttat ccagcataat atgactcaca ctcgagaaaa acccttttta tgcaaagaat   1320

gtgggaaagc tttttactac agctcctcat ttgctcaaca tatgaggatt catactggaa   1380

agaaactcta tgagtgcggt gaatgtggaa aggccttcac gcaccgctcc acatttatcc   1440

agcacaatgt gacccacaca ggagaaaaac catttttatg taaagaatgt ggaaaaacct   1500

tttgcctcaa ctcatccttc actcagcaca tgaggattca cactggagag aaaccctatg   1560

agtgcggtga atgtggaaag gcctttactc atcgctccac tttcatccga cataagagga   1620

cccataccgg agagaagccc tttgagtgca aagaatgtgg gaaggccttt tgtgacagct   1680

cttccttaat tcaacatatg aggattcaca ctggtgagaa gccttatgag tgcagtgaat   1740

gtggaaaggc ttttacacac cactctgttt ttattcgaca taataggacc cacagtggac   1800

aaaaaccctt ggagtgcaaa gaatgtgcaa aagcctttta ctatagctct tccttcactc   1860

gacacatgag gattcacact ggagagaagc cctatgtttg tagagaatgt ggaaaggctt   1920

ttacccaacc tgcaaatttt gttcggcata ataggatcca cactggagaa aaaccttttg   1980

aatgcaaaga atgtgagaaa gccttctgtg acaactttgc tttaactcag cacatgagaa   2040

ctcacactgg agagaaaccc tttgaatgca atgaatgtgg aaagaccttc agccacagtt   2100

catcgttcac tcaccatcga aagattcata ccagagttta aaagatacag gaaggcctat   2160

tacaagtgtg tttgtcttta gtgaactcat agtggtgaca tacctttcct tttgagtata   2220

actattgagg gaaatatttt ggccagagag atgtcttagt atctgataat ttatactaac   2280

tagaaacaga attgtccctg tgaaatcttt ttatggcagg taatcacttg tcatccaaag   2340

aattatatta aagattcacc cagtttagag ccttacactg tacctgagaa taatcgaggg   2400

gagagacctg gtggttaaca tgcatttagg taaaatgtca ggaacaactt tcctcttatt   2460

aatactataa atccatctca agcatatttt aaaataatga gagatggagg aaacaatcta   2520

gaagataaaa gaaaaagatg tgcataactt gttttcagtt tccctgttta tgacagtttg   2580

tcatttggcg ggttggggga tggagcaggg aataagacat tgaaaaagtc tcatcccctt   2640

tgtgtgtttt acatatatat atctctaagt ccagagccag gagagttgga ccattgaggg   2700

cagctctgcc aacatttagt aaaagtattc attgttccaa aactgtcatc tctacccttg   2760

agggagtgtg tctttgtgag aaatataaag gcttgagtca tgaaatactt aacacatgtg   2820

cacatgtaca catgtacatt tatatgcagt gaattgttac tcgtggtagt taggttctgt   2880

gaattttctg tgcacactga attagtgaat gctgaatgat tgttgctagg ggaaatacag   2940

cgttagcttc tgtgagcctc tgatccaaac atttttatca accagtcaac acataacctt   3000

cttctatggg tatttgtttg tttgtttgtt taaagacact ttatcagtgt ttcttgaata   3060

attataatta ttctttataa taaaaatatt ttaattatag c                       3101


<210>  3745
<211>  588
<212>  PRT
<213>  Homosapiens

<400>  3745

Met Ala Ala Pro Ala Leu Ala Leu Val Ser Phe Glu Asp Val Val Val 
1               5                   10                  15      


Thr Phe Thr Gly Glu Glu Trp Gly His Leu Asp Leu Ala Gln Arg Thr 
            20                  25                  30          


Leu Tyr Gln Glu Val Met Leu Glu Thr Cys Arg Leu Leu Val Ser Leu 
        35                  40                  45              


Gly His Pro Val Pro Lys Pro Glu Leu Ile Tyr Leu Leu Glu His Gly 
    50                  55                  60                  


Gln Glu Leu Trp Thr Val Lys Arg Gly Leu Ser Gln Ser Thr Cys Ala 
65                  70                  75                  80  


Gly Glu Lys Ala Lys Pro Lys Ile Thr Glu Pro Thr Ala Ser Gln Leu 
                85                  90                  95      


Ala Phe Ser Glu Glu Ser Ser Phe Gln Glu Leu Leu Ala Gln Arg Ser 
            100                 105                 110         


Ser Arg Asp Ser Arg Leu Gly Gln Ala Arg Asp Glu Glu Lys Leu Ile 
        115                 120                 125             


Lys Ile Gln Glu Gly Asn Leu Arg Pro Gly Thr Asn Pro His Lys Glu 
    130                 135                 140                 


Ile Cys Pro Glu Lys Leu Ser Tyr Lys His Asp Asp Leu Glu Pro Asp 
145                 150                 155                 160 


Asp Ser Leu Gly Leu Arg Val Leu Gln Glu Arg Val Thr Pro Gln Asp 
                165                 170                 175     


Ala Leu His Glu Cys Asp Ser Gln Gly Pro Gly Lys Asp Pro Met Thr 
            180                 185                 190         


Asp Ala Arg Asn Asn Pro Tyr Thr Cys Thr Glu Cys Gly Lys Gly Phe 
        195                 200                 205             


Ser Lys Lys Trp Ala Leu Val Arg His Gln Gln Ile His Ala Gly Val 
    210                 215                 220                 


Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Cys Arg Tyr Met Ala 
225                 230                 235                 240 


Asp Val Ile Arg His Met Arg Leu His Thr Gly Glu Lys Pro Tyr Lys 
                245                 250                 255     


Cys Ile Glu Cys Gly Lys Ala Phe Lys Arg Arg Phe His Leu Thr Glu 
            260                 265                 270         


His Gln Arg Ile His Thr Gly Asp Lys Pro Tyr Glu Cys Lys Glu Cys 
        275                 280                 285             


Gly Lys Ala Phe Thr His Arg Ser Ser Phe Ile Gln His Asn Met Thr 
    290                 295                 300                 


His Thr Arg Glu Lys Pro Phe Leu Cys Lys Glu Cys Gly Lys Ala Phe 
305                 310                 315                 320 


Tyr Tyr Ser Ser Ser Phe Ala Gln His Met Arg Ile His Thr Gly Lys 
                325                 330                 335     


Lys Leu Tyr Glu Cys Gly Glu Cys Gly Lys Ala Phe Thr His Arg Ser 
            340                 345                 350         


Thr Phe Ile Gln His Asn Val Thr His Thr Gly Glu Lys Pro Phe Leu 
        355                 360                 365             


Cys Lys Glu Cys Gly Lys Thr Phe Cys Leu Asn Ser Ser Phe Thr Gln 
    370                 375                 380                 


His Met Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu Cys 
385                 390                 395                 400 


Gly Lys Ala Phe Thr His Arg Ser Thr Phe Ile Arg His Lys Arg Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe 
            420                 425                 430         


Cys Asp Ser Ser Ser Leu Ile Gln His Met Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Thr His His Ser 
    450                 455                 460                 


Val Phe Ile Arg His Asn Arg Thr His Ser Gly Gln Lys Pro Leu Glu 
465                 470                 475                 480 


Cys Lys Glu Cys Ala Lys Ala Phe Tyr Tyr Ser Ser Ser Phe Thr Arg 
                485                 490                 495     


His Met Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys 
            500                 505                 510         


Gly Lys Ala Phe Thr Gln Pro Ala Asn Phe Val Arg His Asn Arg Ile 
        515                 520                 525             


His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Glu Lys Ala Phe 
    530                 535                 540                 


Cys Asp Asn Phe Ala Leu Thr Gln His Met Arg Thr His Thr Gly Glu 
545                 550                 555                 560 


Lys Pro Phe Glu Cys Asn Glu Cys Gly Lys Thr Phe Ser His Ser Ser 
                565                 570                 575     


Ser Phe Thr His His Arg Lys Ile His Thr Arg Val 
            580                 585             


<210>  3746
<211>  5302
<212>  DNA
<213>  Homosapiens

<400>  3746
agaccggccc ctgcgcgata tgagcaccgc tcaggactgc agctgttggg caccagcagc     60

caggtctgca ggctccgcga agcctggccc ggaccgtagc ttctgcaagc agtccaggtg    120

tatcctgggg tcactggagg gcagagcctg ctcagagcga gtacagaagc agcccaggtc    180

ttcccagcac caggttcact ggaagtgcca ggccaccacc tccttcatgc tcctctgtga    240

tcacctctcc aagtcccggt gtcaggagcc ttctctgtgg ccgccctgga gagacttgag    300

cctgggacgt gacgtgctgg gctgtgaagc tttctgagaa gggaaacctg tggcctgacc    360

tgcctgaatg ctgcacccaa cctcatctct tcctgggaga aaccaacaac tgtcagcatt    420

gacaccatca ggcctttccc ttctaattta accttgcagc caaccacacg gctatctgtg    480

cgggatctct ccccaagctc aaggacatga gatgcggatc aggcccaaga ggctggatgc    540

caaacctatc ctctccatgt gaagcaccaa cttgggggtg tcaactaaaa atatgagacc    600

cgtaaacttg gaaaggaaaa ctttatttct tgagaagggt tgcaaactgc aggctgggaa    660

gtgacacctc cagctgagac cacaaacagt ggactttctc aaactggggt attgacctct    720

gatgaaccgc catgcaaacc cgtgcctttc aacataaaaa gaagcccttc gaggtgctca    780

ccttcaagct tgctagagga ggaggaagag caggttgagt ttgacataac tagaatgggt    840

tgagcctttc cagcagagta aggttctttc atggtggaca gtggccaccc actgccattt    900

ctacaagaag attttgcttc ttaggcactg agttcctggt tctttcacta gagaaaaatg    960

agtaggttgg caatccagta cttccatctt ctgtgaagac ctgggcaggc gacgggggct   1020

tgggggcggg ggcagggacc aaagacaagg ctgccatttg ctgtgcccac cacagaggga   1080

catttactcc acctgaagca caagtatttt ctcagtgatg ttggctccta caaagtcaaa   1140

aggggtaggc tccctggctt acgctccagg agtttggact gaaagggaca ctaaaagtgt   1200

cttcctctaa gtttatgatg ttgccctcct ctggctacaa cagtgctctg gccataagca   1260

tcccaggttc tctgaatgat ggtgggtatg gaaatgttcc caaacacagg tatggcggtg   1320

tcccctccca ctgtaccaat ctatgcccag ggctggaagg tccgtggtgc tctgaactgg   1380

attcataaac agtagcatct ccaaccacaa gtgtggtgtc aggccctcca acagtagcac   1440

atgtgctccc gtgggtgcct gatagaaagt gggaacatgt gtttattagc caggtgggcc   1500

ccaaatgctc tgacgaggtg cagaaagagg actctttgtc acagttgtgc tgtgccctcc   1560

cattgcaaca catgtgctct gaacaggtgg agcccaggtg ctttgcatgt aggcggacac   1620

aagagggcct ctaagcacaa gtgtggtgtt ggaaccctca aggctaccga tgcattctgg   1680

ccaggtgtgt cccaggtggt ctgactatag acagcaacag aattatctcc agcaccgtta   1740

tagagatacc cgtccaactg atgtgctcta gcgggatggg acccgggtga tccgaacaca   1800

aggaggaaca gaagtttatt ctgatatatg ctccttctta gcgatgttat ctacttcaat   1860

agtaacggta tgctttggct gggtgggcct cagtcactct gtagccagga aggaaagggc   1920

tcccaaaaca gatttctgct ccgtagagct gatcttccct cattgcaaca gggatgctat   1980

aggcaggcag gacctggtgc tcaggtctaa gcccctccta gaataagttg tggttctgag   2040

tgttgtcagc ccttctgcag atttcaatga cccctgacaa ggagccaggg tttgggacag   2100

acacaatgac tgcaaacctg ccaccaccca aaggggctta gatattgatg gtgcatggca   2160

ctgctgcagt ggccctttat cttgatcccc tttttttttt gagacggagt ttcgctctgt   2220

tgcccaggct ggagtgcagt ggcgcgatct tggctcactg caagctccgc ctccagggtt   2280

catgccattc tcctgcctca ggcctccacc tctcaggttc aagcgattct cccgcctccg   2340

cctctgcctc ctgggttcaa gcaaacctcc gtctcctgga tccaagtgat tctcctgcct   2400

cagcctccca attagctggg actacaggtg tgcgcaacca cgcccagcta atttttgtat   2460

ttttagtaga gatggggttt caccatgttg gccaggctgg tctcgaactc ctgacctcag   2520

gtgatctgcg cgcctcggcc tcccaaagtg ctgggattac aggcgtgaga caccgtgccc   2580

ggccctcagt ctcttttaag caaggatcag gggagtaatc agatggccca tatagcgctc   2640

ctgctattga aggagcgcag atgtcgctca gatagcgaca ggaagagaag tcagtttccc   2700

cctacaggta ggatcagtac ttttcctaag tggctgcact tctttgaggt gcaagcatac   2760

agtgctgtct ttctgagagc cctggcgtga caccaagggg aggccccctt ctgatgtaaa   2820

cactgagctt gctgggttgc ataaggcctc tcaggggtga tataaaccga gggggtaaag   2880

gtgaccgtgt tgctcccagg aactgttttc agaagatgca caggtgcagc aggaggattc   2940

ctgccagaag caggaacaga gagggcaggg agaaaaagga ggatggtggc ctgggggcca   3000

ggcggggtga ggcttactga ggaagttgtc cgtgaagagc agtttgtgtg ctgtctgaca   3060

ctgagagtct agtaagaaat ttggagaggt ctcctagctg catgttcctc caaggcaaac   3120

catgctggat gtttgtgaca tgtcattgga acacacacca gagaaagtgt gtgctagagc   3180

agagagggaa gacaaggcac caaaggacaa aggggaatcc cagcaggact tttgagagct   3240

tgagacagct catgctcttt gcaggtgctt ggcaccaggt gtgcccgatg acatggaaaa   3300

gcatccagga ctgtgtatta taggacccca cataactgtc acccccagat cgccaggtct   3360

gcaggctcct cagcatctaa cctaggggca gcaactagtg cctgtgagtc tcctagccct   3420

tttctctggg gttattggag gtcagaggtc agagcgccct agatcctgcc aggaaggggc   3480

cctggctcac aggaggtcag ggtaggagag gtgggggtgt ggccagcagg gatcaactct   3540

gtctcatgcc attactggtg cacccaggtg gcccagcagg gctgcagctg caagacacgt   3600

gctctgatgg ggaggagaga ccaagcagtg tggggcgtga tttgccctga cctcttcctt   3660

tcaggcaacc tctgcagagg acactagttt acccccacaa tgtccccttc ccatgtggta   3720

gctcagggtt accacacact ctttcctcca gggatccctc tagggcctct caagtcttgg   3780

agcaggcata tcttctctgt ggccacccag gaaggtgtgg gtccatgggc atgagatgtg   3840

agtccagctg ggctgtgaag gtttctgaga tgggtacttg gcaccccaat tttcccaggt   3900

cctgcacccc ataccatccc ttccaggcaa gcagatcttc cctcttttaa caaatttttc   3960

gaattgcaaa cagcatttag gactttgcgc cttcctcagg tcacccatgt gggcgtaagg   4020

gagagtcagg atttgaactc agactgtctg attccagagt ttatccattg accacctgac   4080

agtggtgatg cctcatcatg tgtgtcacgt atttacattt ttaaatagtc cttagggtac   4140

ttagcaccat gtacacctgt catgagagtg ttcactgcct gcatcagaag atgcagggtg   4200

gagagcacca attgtcagca caaccatatt gggcatttct ctgctaaatg agtcttgcac   4260

aaaccacaca gctgtctgtg aactatcttc tcccaggtac aggacaggag gccacttagg   4320

tgcaagatac actctgtctt aagagcctta tgctccaagg acaccaacat ctcttgtgac   4380

aattccatag acctactttt taggatcctg gctgaaattg gcaatttact gatatcaaat   4440

agtgtactct atcaggatgg taaatagttc cttatattta gaactctttt ttttttttgg   4500

acagagtttc actcttgttg cccaggctgg agtgcaatag tgcaatctca gctccctata   4560

gcctccacct cccgggttca agtgattatc ctgcctcagc ctctcgagta gctgggacta   4620

caggcatgca ccactatgcc cagctaattt tgtattttta gtagacactg ggtttcacca   4680

cgttggtcag gctggtctcg aactcctgac ctcaggtgat ccacctacct cagcttccca   4740

aaagcgtgag ccaccgcgcc cggcctttag aatgctttaa ttttctctca gagactattt   4800

tgtggttggg aatgacaaat tacagttcat gagctgaatt ctttccagtc tgtttctgta   4860

atgccaataa ccttagaatg gtgataagag ttttcaaagt ttgtagaaaa gaggaaagga   4920

aaaaagggag aaaaacagag gaaaatatgc aacagagacc atatgcaatc ttcagagcct   4980

ataatatcta ctatctggtc ctttacagaa aaatttgcct cttttgtgat tttcagtgta   5040

taagtcttgt acagtattta ctaatttatc cttatgtgtt ttataagttt tttgtatgct   5100

atcgtaaatg gtatctttta cattttagtt ttcagtattc accactggaa aatacagttg   5160

atttttatat attcaccttg tatgctagaa ctttgctaaa ttcactcttt acttttaata   5220

gtttctttgt gaattcctta ggatattcta tgttcacagt catgttttct atgaacaaag   5280

agagttttgc ttcttccttt tt                                            5302


<210>  3747
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  3747

Met Val His Gly Thr Ala Ala Val Ala Leu Tyr Leu Asp Pro Leu Phe 
1               5                   10                  15      


Phe Leu Arg Arg Ser Phe Ala Leu Leu Pro Arg Leu Glu Cys Ser Gly 
            20                  25                  30          


Ala Ile Leu Ala His Cys Lys Leu Arg Leu Gln Gly Ser Cys His Ser 
        35                  40                  45              


Pro Ala Ser Gly Leu His Leu Ser Gly Ser Ser Asp Ser Pro Ala Ser 
    50                  55                  60                  


Ala Ser Ala Ser Trp Val Gln Ala Asn Leu Arg Leu Leu Asp Pro Ser 
65                  70                  75                  80  


Asp Ser Pro Ala Ser Ala Ser Gln Leu Ala Gly Thr Thr Gly Val Arg 
                85                  90                  95      


Asn His Ala Gln Leu Ile Phe Val Phe Leu Val Glu Met Gly Phe His 
            100                 105                 110         


His Val Gly Gln Ala Gly Leu Glu Leu Leu Thr Ser Gly Asp Leu Arg 
        115                 120                 125             


Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Arg His Arg Ala 
    130                 135                 140                 


Arg Pro Ser Val Ser Phe Lys Gln Gly Ser Gly Glu 
145                 150                 155     


<210>  3748
<211>  2735
<212>  DNA
<213>  Homosapiens

<400>  3748
aatgtagcct gaaactacat ttctcagcgg ccactggaac gacctcaatc tctgcctcct     60

cgccagttca ttgtggtcgt tgacccggca gcgagctttg gagttcatcg agggagaagt    120

cagcgcccag ctccgaggtt ggagcagccc cgccgggcaa cttgaatttc tgcaaacgaa    180

cacagcaccg ggagctctgc agacctgtgt cggcgcggaa cccggactga gacatgcctt    240

ttgaacttct cagatagagg aaccccagtg aagactgatc agttcttaca attctcaaag    300

catggcccat aaatatgtgg gtttgcagta tcacggatca gtgacatttg aggatgtggc    360

catagccttc tcccagcagg agtgggagag tctggactct tcccagaggg gcttgtacag    420

agatgtgatg ttggagaact acaggaactt ggtgtcaatg ggacattccc gttctaaacc    480

acatgtgatc gccttattgg aacaatggaa agagcctgaa gtgacagtga ggaaagatgg    540

aagaagatgg tgcacaggat aagaaagctc cagtctacaa acaaaacatg ccagaagatt    600

tttaggcgat gatgccacct gcacatggaa ccaaaagatt tgcagttgga agatgataca    660

atcggctgta aagaaatgcc cacctctgaa aactgtccat cttttgctct acatcagaaa    720

ataagtagac agaaaccacg tgaatgtcgg gaatatggaa agaccctttg tcaagactca    780

aagcctgttc aacatgaaag aatacatagt agtgaaaaac ccaacagatg taaagaatgt    840

gggaagaact ttagtaatgg acatcaactc accatacatc agagattgca tgttggtgag    900

aaaccctata aatatgaaaa atgtgggaag gcctttatca gtggctcagc ctttgttagg    960

catgggagaa ttcacactgg tgagaagcca ctcaaatgta agcaatgtgg aaagactatt   1020

agcggtagct atcaacttac agtacataag agtattcata ctgggaagaa accatatgag   1080

tgcggggaat gttggaaagc ttttctagta tatggaaagc ttacccggca tcagagtact   1140

cacactggtg aaaaaccctt tgggtgtgag gagtgtggga aggccttcag taccttttca   1200

tacctggttc aacatcagcg aattcatacc agtgaaaaac cttacgaatg caaagaatgt   1260

gggaaggcct ttagcactag ctcacccctt gttaagcatc agagaattca tactggcgag   1320

aaaccctatg aatgtaagga gtgtgggaag tccttcactg tgtatggaca gcttactcga   1380

catcagagta ttcatactgg tgagaaacct tttgaatgta aggaatgtgg aaaggccttt   1440

agacttagtt ccttccttca tgcacatcag cgaattcatg cagagataaa gccctacgga   1500

tgcaaggaat gcgggaaaac cttcagtcgt gcctcatatc ttgttcaaca tggaagactt   1560

cacactggcg agaagcccta tgaatgtaag gagtgtggca aggcctttag tactggctca   1620

taccttgttc agcatcagag gatccatact ggggagaaac cctatgaatg taaggaatgt   1680

ggcaaagcct ttattagtcg ccatcagctt accgtacatc aaagggttca tactggagag   1740

aaaccctatg agtgtaagga atgtggcaag gccttcagag tgcacgtaca tctcacacag   1800

catcggaaaa ttcatactga tgtaaagccc tatgaatgta aggaatgtgg aaagactctt   1860

agtcgagcct cgtaccttgt acaacatagc agaatccata ctggtaagaa gccctatgag   1920

tgtaaggagt gtggcaaggc cttcagttct ggctcatacc ttgttcagca tcaaagaatt   1980

catactgggg agaaacccta tgaatgtaac aaatgtggga aagcctttac tgtttatgga   2040

caacttattg gacatcagag tgttcacact ggtgagaaac cttttgaatg taaggaatgc   2100

gggaaggcct ttagacttaa ttcattcctt actgaacatc agcgggtaca cactggtgag   2160

aaacccttta aatgcaaaaa atgtgggaag acctttagat acagttcagc ccttaaagtg   2220

catctgagaa aacatatgag tgttataccc taagagtctg aggagtgtgg gaagtgcttc   2280

gtgtgtggct caaacattgt tgaacatcgg ggaatttatg ctggtaggaa actttcaaat   2340

gtgaagaata ttggcaggtc tattctcatc ttataattca taatataact cagaaaacat   2400

aagaatattc ctttgtcatt tataggtttg taataccaat atttatactg gtggaccatt   2460

cagaaaaagt gggaaacgtt attacttaat ggttacagca ctgacagcat gaacttttat   2520

atgatgcatt tattctaatg tgattgtatg aacaagtgaa taaaaaacct tggacctcct   2580

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2700

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                              2735


<210>  3749
<211>  542
<212>  PRT
<213>  Homosapiens

<400>  3749

Met Glu Pro Lys Asp Leu Gln Leu Glu Asp Asp Thr Ile Gly Cys Lys 
1               5                   10                  15      


Glu Met Pro Thr Ser Glu Asn Cys Pro Ser Phe Ala Leu His Gln Lys 
            20                  25                  30          


Ile Ser Arg Gln Lys Pro Arg Glu Cys Arg Glu Tyr Gly Lys Thr Leu 
        35                  40                  45              


Cys Gln Asp Ser Lys Pro Val Gln His Glu Arg Ile His Ser Ser Glu 
    50                  55                  60                  


Lys Pro Asn Arg Cys Lys Glu Cys Gly Lys Asn Phe Ser Asn Gly His 
65                  70                  75                  80  


Gln Leu Thr Ile His Gln Arg Leu His Val Gly Glu Lys Pro Tyr Lys 
                85                  90                  95      


Tyr Glu Lys Cys Gly Lys Ala Phe Ile Ser Gly Ser Ala Phe Val Arg 
            100                 105                 110         


His Gly Arg Ile His Thr Gly Glu Lys Pro Leu Lys Cys Lys Gln Cys 
        115                 120                 125             


Gly Lys Thr Ile Ser Gly Ser Tyr Gln Leu Thr Val His Lys Ser Ile 
    130                 135                 140                 


His Thr Gly Lys Lys Pro Tyr Glu Cys Gly Glu Cys Trp Lys Ala Phe 
145                 150                 155                 160 


Leu Val Tyr Gly Lys Leu Thr Arg His Gln Ser Thr His Thr Gly Glu 
                165                 170                 175     


Lys Pro Phe Gly Cys Glu Glu Cys Gly Lys Ala Phe Ser Thr Phe Ser 
            180                 185                 190         


Tyr Leu Val Gln His Gln Arg Ile His Thr Ser Glu Lys Pro Tyr Glu 
        195                 200                 205             


Cys Lys Glu Cys Gly Lys Ala Phe Ser Thr Ser Ser Pro Leu Val Lys 
    210                 215                 220                 


His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys 
225                 230                 235                 240 


Gly Lys Ser Phe Thr Val Tyr Gly Gln Leu Thr Arg His Gln Ser Ile 
                245                 250                 255     


His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe 
            260                 265                 270         


Arg Leu Ser Ser Phe Leu His Ala His Gln Arg Ile His Ala Glu Ile 
        275                 280                 285             


Lys Pro Tyr Gly Cys Lys Glu Cys Gly Lys Thr Phe Ser Arg Ala Ser 
    290                 295                 300                 


Tyr Leu Val Gln His Gly Arg Leu His Thr Gly Glu Lys Pro Tyr Glu 
305                 310                 315                 320 


Cys Lys Glu Cys Gly Lys Ala Phe Ser Thr Gly Ser Tyr Leu Val Gln 
                325                 330                 335     


His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys 
            340                 345                 350         


Gly Lys Ala Phe Ile Ser Arg His Gln Leu Thr Val His Gln Arg Val 
        355                 360                 365             


His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe 
    370                 375                 380                 


Arg Val His Val His Leu Thr Gln His Arg Lys Ile His Thr Asp Val 
385                 390                 395                 400 


Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Thr Leu Ser Arg Ala Ser 
                405                 410                 415     


Tyr Leu Val Gln His Ser Arg Ile His Thr Gly Lys Lys Pro Tyr Glu 
            420                 425                 430         


Cys Lys Glu Cys Gly Lys Ala Phe Ser Ser Gly Ser Tyr Leu Val Gln 
        435                 440                 445             


His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Lys Cys 
    450                 455                 460                 


Gly Lys Ala Phe Thr Val Tyr Gly Gln Leu Ile Gly His Gln Ser Val 
465                 470                 475                 480 


His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe 
                485                 490                 495     


Arg Leu Asn Ser Phe Leu Thr Glu His Gln Arg Val His Thr Gly Glu 
            500                 505                 510         


Lys Pro Phe Lys Cys Lys Lys Cys Gly Lys Thr Phe Arg Tyr Ser Ser 
        515                 520                 525             


Ala Leu Lys Val His Leu Arg Lys His Met Ser Val Ile Pro 
    530                 535                 540         


<210>  3750
<211>  3302
<212>  DNA
<213>  Homosapiens

<400>  3750
gggtgcctga cagtgtggat atgacatcag ccatggccag aggggcttat ggcaggcctg     60

gctctgattt ttgccatgga acagagggca aggacttacc ttctgagcat aacgtttctg    120

tagaaggagt ggcacaggac aggagtcccg aggcaactct gtgcccccag aagacctgcc    180

cctgtgacat atgtggccta cgtttgaaag acattttgca tttggctgaa caccagacaa    240

cacatcccag gcagaaacca tttgtgtgtg aggcatatgt gaaaggctct gagttcagtg    300

caaaccttcc ccagaaacag gtgcagcaga acgtacacaa ccctatcaga acggaggagg    360

gccaggcttc ccctgtaaag acctgcagag accacacatc agatcagctt tccacctgca    420

gggagggtgg gaaggacttt gtggccacag cagggtttct gcagtgtgag gtcactccca    480

gcgatgggga gccgcacgag gccaccgaag gtgtggtgga ttttcacatt gcactaaggc    540

ataacaagtg ctgtgaatct ggggatgcct tcaataacaa atccactctt gttcagcacc    600

agagaatcca cagcagagaa aggccttatg aatgcagcaa atgtggaatc ttcttcactt    660

acgccgctga cctcactcaa caccagaaag ttcacaatag aggaaaaccg tatgagtgct    720

gtgaatgtgg aaaattcttc agccagcact ccagccttgt taaacatcgc agggttcaca    780

ccggtgaaag ccctcacgtg tgtggtgact gtgggaaatt cttcagccga agctccaacc    840

tcattcagca taagagggtt cacactggtg aaaagccata tgagtgcagc gactgtggga    900

agttcttcag ccagcgttcc aacctcattc atcataagag ggttcatacg ggcagaagtg    960

cccatgagtg cagtgaatgt gggaaatctt tcaactgcaa ctccagccta attaaacatt   1020

ggagagttca cactggagaa agaccttaca agtgtaacga atgtgggaaa ttcttcagcc   1080

acattgccag cctcattcaa catcagatag ttcacactgg cgagcggcct cacgggtgtg   1140

gtgagtgtgg gaaagccttc agccgaagct ctgacctcat gaaacatcag cgagttcaca   1200

ctggtgagcg gccttatgaa tgcaatgaat gtgggaagtt atttagccag agctccagcc   1260

tcaatagcca tcggagactt cacactggtg aacggcctta ccagtgcagt gaatgtggga   1320

aattctttaa ccaaagctcc agcctcaata accaccggag acttcacacc ggcgagcggc   1380

cttatgagtg cagcgaatgt gggaaaacct tcaggcagag gtccaatctg aggcagcacc   1440

tgaaagttca caaaccagac aggccttacg aatgcagcga atgtgggaaa gccttcaacc   1500

aaaggcctac cctcattcgg catcagaaga ttcacatcag agaaaggagc atggagaatg   1560

tgctccttcc ctgttcacag cacacaccag agataagctc tgagaacaga ccttatcagg   1620

gcgctgtcaa ctacaagttg aaacttgttc atccaagtac ccaccctggg gaggttccct   1680

aggaatgcta gctgtgttgg aagctttctg gagacaagtt acattctctt actgtagagt   1740

ttatcagcgt tttttcactg ctggggttgt gatagaagcc atgtcagcac cacacactgc   1800

agctctccaa agagtgtgtc caccactcca ctgtgctcag ggaaggcaga cctctcctct   1860

ctctttccaa tccctaaagg gaattaggag tagtctgaag ccttgggaag atgtcattcc   1920

cgccctgtat ggctggttta gccatggaca tgaccagctt ttggctgtga agacctgagc   1980

agggttttgc caacagcttg ttctagagaa ggtttccctt tttctgggac attgttggtc   2040

tcatgttatg cctgtgaagg atttgtccag ccttcatgtt actctacaca acaacttatc   2100

tcctgtgtat tgccctggtt catgtgatga taatggcctt atgataaagc cgcctttagt   2160

cttccatgtt ctgatcactg tgtggggtgg ttcaagagca gagttaagat ctaccaaact   2220

gaaggggtct ccagattatc ttggagggga caggaggatg gcagagaaac aactgtcaat   2280

ccagatttga cctcatttgc attgccacca aggcctccta ggaaaaattg taggaattta   2340

tgggtataat attgtggtct gaatggcgtg aatttttatc ccgaggaggg ggcagttgtg   2400

acaacctcca gtgcatgtgg gaacagcatg aattgggtcc cttattccca gggggtgccc   2460

catattcccc aatactgtaa agcagatgct gtttagcacc tgccaaggag ccatatgccc   2520

tgaagttcag cattaggcag gtatctctta actgtaagac ataccaggcc cagctgggac   2580

cataatttgt acagaaacac tggatgtgat taatagggag taggcgagat tatagcaaac   2640

cagcagaaat ggaactctgc taaatgtgca tccgtgaatg ctcccttgaa tgtggctgtg   2700

caggattcag ggtttgcaga aattctcagg acctcagacc tctgtcctat gactaatgtt   2760

actggcagag caaataatct aaaggttttg gttttgtgga ttaccatctc cgtgctgtgc   2820

atctgaaggc cagtgctgtg ctggcaggaa aatagggact gagaaaaagc agatcctata   2880

ctatagggac tgtagtatct atgacgtagc cagccattct ttgctcccaa ggcaagaaga   2940

aagagatgac agagtcaata tagggttgcc aaatcggatt ttctaaaatg agtaggaagt   3000

tggattttta tgtgcaacag tttcttttaa tgctttgttg atatgtgatt gtcatgcaat   3060

aattattcat atttggtaag ttttgtacat atattatgta cactcaggga accaatacca   3120

taatcatgat aatgaacgta tccatcacct gcaaagctac ctcatgcccc tttacattcc   3180

ctccttgcct tccctaggaa accgttgatt tacatttttt actttagatt tgtttgcctt   3240

ttctagaatt aacacaattg gaatcataaa gtatttatac tctcaaaaaa aaaaaaaaaa   3300

aa                                                                  3302


<210>  3751
<211>  553
<212>  PRT
<213>  Homosapiens

<400>  3751

Met Thr Ser Ala Met Ala Arg Gly Ala Tyr Gly Arg Pro Gly Ser Asp 
1               5                   10                  15      


Phe Cys His Gly Thr Glu Gly Lys Asp Leu Pro Ser Glu His Asn Val 
            20                  25                  30          


Ser Val Glu Gly Val Ala Gln Asp Arg Ser Pro Glu Ala Thr Leu Cys 
        35                  40                  45              


Pro Gln Lys Thr Cys Pro Cys Asp Ile Cys Gly Leu Arg Leu Lys Asp 
    50                  55                  60                  


Ile Leu His Leu Ala Glu His Gln Thr Thr His Pro Arg Gln Lys Pro 
65                  70                  75                  80  


Phe Val Cys Glu Ala Tyr Val Lys Gly Ser Glu Phe Ser Ala Asn Leu 
                85                  90                  95      


Pro Gln Lys Gln Val Gln Gln Asn Val His Asn Pro Ile Arg Thr Glu 
            100                 105                 110         


Glu Gly Gln Ala Ser Pro Val Lys Thr Cys Arg Asp His Thr Ser Asp 
        115                 120                 125             


Gln Leu Ser Thr Cys Arg Glu Gly Gly Lys Asp Phe Val Ala Thr Ala 
    130                 135                 140                 


Gly Phe Leu Gln Cys Glu Val Thr Pro Ser Asp Gly Glu Pro His Glu 
145                 150                 155                 160 


Ala Thr Glu Gly Val Val Asp Phe His Ile Ala Leu Arg His Asn Lys 
                165                 170                 175     


Cys Cys Glu Ser Gly Asp Ala Phe Asn Asn Lys Ser Thr Leu Val Gln 
            180                 185                 190         


His Gln Arg Ile His Ser Arg Glu Arg Pro Tyr Glu Cys Ser Lys Cys 
        195                 200                 205             


Gly Ile Phe Phe Thr Tyr Ala Ala Asp Leu Thr Gln His Gln Lys Val 
    210                 215                 220                 


His Asn Arg Gly Lys Pro Tyr Glu Cys Cys Glu Cys Gly Lys Phe Phe 
225                 230                 235                 240 


Ser Gln His Ser Ser Leu Val Lys His Arg Arg Val His Thr Gly Glu 
                245                 250                 255     


Ser Pro His Val Cys Gly Asp Cys Gly Lys Phe Phe Ser Arg Ser Ser 
            260                 265                 270         


Asn Leu Ile Gln His Lys Arg Val His Thr Gly Glu Lys Pro Tyr Glu 
        275                 280                 285             


Cys Ser Asp Cys Gly Lys Phe Phe Ser Gln Arg Ser Asn Leu Ile His 
    290                 295                 300                 


His Lys Arg Val His Thr Gly Arg Ser Ala His Glu Cys Ser Glu Cys 
305                 310                 315                 320 


Gly Lys Ser Phe Asn Cys Asn Ser Ser Leu Ile Lys His Trp Arg Val 
                325                 330                 335     


His Thr Gly Glu Arg Pro Tyr Lys Cys Asn Glu Cys Gly Lys Phe Phe 
            340                 345                 350         


Ser His Ile Ala Ser Leu Ile Gln His Gln Ile Val His Thr Gly Glu 
        355                 360                 365             


Arg Pro His Gly Cys Gly Glu Cys Gly Lys Ala Phe Ser Arg Ser Ser 
    370                 375                 380                 


Asp Leu Met Lys His Gln Arg Val His Thr Gly Glu Arg Pro Tyr Glu 
385                 390                 395                 400 


Cys Asn Glu Cys Gly Lys Leu Phe Ser Gln Ser Ser Ser Leu Asn Ser 
                405                 410                 415     


His Arg Arg Leu His Thr Gly Glu Arg Pro Tyr Gln Cys Ser Glu Cys 
            420                 425                 430         


Gly Lys Phe Phe Asn Gln Ser Ser Ser Leu Asn Asn His Arg Arg Leu 
        435                 440                 445             


His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Thr Phe 
    450                 455                 460                 


Arg Gln Arg Ser Asn Leu Arg Gln His Leu Lys Val His Lys Pro Asp 
465                 470                 475                 480 


Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Asn Gln Arg Pro 
                485                 490                 495     


Thr Leu Ile Arg His Gln Lys Ile His Ile Arg Glu Arg Ser Met Glu 
            500                 505                 510         


Asn Val Leu Leu Pro Cys Ser Gln His Thr Pro Glu Ile Ser Ser Glu 
        515                 520                 525             


Asn Arg Pro Tyr Gln Gly Ala Val Asn Tyr Lys Leu Lys Leu Val His 
    530                 535                 540                 


Pro Ser Thr His Pro Gly Glu Val Pro 
545                 550             


<210>  3752
<211>  2715
<212>  DNA
<213>  Homosapiens

<400>  3752
gtcgggtggg ggcggcggcc gcggaaggcc aggccggtgc cctgcgggga cgcccagcgc     60

agcccagccc cgcgcagccc agccctgccc tgccctgccc tgccctgccc tgccctgcgc    120

ccggggcgcg cccaccgcgc cgcatccatg ttcgacacca caccccactc tggccggagc    180

acgccaagca gctccccatc gctccggaaa cggctgcagc tcctgccccc aagccggccc    240

ccacctgagc cagaaccagg caccatggtg gagaagggat cagatagctc ctcagagaag    300

ggtggggtgc ctgggacccc cagcacccag agcctaggca gccggaactt catccgcaac    360

agcaagaaga tgcagagctg gtacagtatg ctgagcccca cttataagca gcgtaatgag    420

gacttccgga aactgttcag caaactcccc gaagcagaac gcctcattgt ggattactcc    480

tgcgccctgc agcgtgagat cctgctccag ggccgcctct acctctctga gaactggatc    540

tgcttctaca gcaacatctt ccgctgggag accacgatct ccatccagct gaaggaagtg    600

acatgtctga agaaggaaaa gacggccaag ctgatcccca acgccatcca gatctgcacg    660

gagagcgaga agcatttctt cacttccttt ggggcccgtg accgctgctt cctcctcatc    720

ttccgcctct ggcagaatgc actgcttgaa aagacgctga gtccccgcga gctctggcac    780

ctggtgcatc agtgctacgg ctcagagctg ggcctcacca gtgaggatga ggactatgtc    840

tcccccttgc agctgaacgg tctggggacc cccaaggaag tgggagatgt gatcgccctg    900

agcgacatca cctcctcggg ggcagctgac cgcagccagg agccaagccc agtgggttcg    960

cgccgtggcc atgtcacgcc caacctttcc cgagccagca gcgacgcaga ccatggggca   1020

gaggaggaca aggaggagca ggtagacagc cagccagacg cctcctccag ccagacagtg   1080

accccggtgg ctgaaccccc gagcacagag cccacccagc ctgacgggcc caccaccctg   1140

ggccccttgg atctgctgcc cagtgaggag ctattgacag acacaagtaa ctcctcttca   1200

tccactgggg aggaagcaga cttggctgcc ctgcttcccg acctctccgg ccgcctcctc   1260

atcaactctg tcttccatgt gggcgctgag cggctccagc agatgctctt ctcggactcg   1320

cccttcctcc agggcttcct acagcagtgc aagttcacag acgtgaccct gagcccctgg   1380

agtggggaca gcaagtgcca ccagcgccgg gtgctgacgt acaccatccc catcagcaac   1440

ccactgggcc ccaagagcgc ctccgtggtg gagacacaga cgctgttccg gcgcggcccc   1500

caggccggcg ggtgtgtggt ggactccgag gtgctgacgc agggcatccc ctaccaggac   1560

tacttctaca ctgcccaccg ctactgcatc ctgggtctgg cccggaacaa ggcgcggctc   1620

cgagtgtctt ctgagatccg ctaccgaaag cagccgtgga gcctggtgaa gtcgctcatt   1680

gagaagaact cgtggagcgg cattgaagac tatttccacc atctggagcg agagctcgcc   1740

aaggctgaga agctgtctct ggaggaaggc gggaaggatg cccggggctt gctatccggc   1800

ctgcggcggc ggaagcggcc cctgagctgg cgggctcacg gggacgggcc ccagcaccca   1860

gatcctgacc cctgtgcccg ggccggcatt cacacctcgg gctccctcag ctcccgcttc   1920

tccgaaccat ctgtggacca gggccccggg gcaggcatcc ccagtgccct ggttctcatc   1980

agcattgtga tctgtgtgag ccttatcatc ctcatcgccc tcaacgtcct gctcttctac   2040

cgcctctggt ccctggaaag gacagcccac acctttgagt cctggcacag cctggccctg   2100

gccaagggca agttccccca gacggccaca gagtgggccg agatcctggc gctgcagaag   2160

caattccaca gcgtggaggt gcacaagtgg aggcagatcc tgcgggcctc cgtggagctc   2220

ctggatgaga tgaagttctc gctggagaag ctgcaccaag gcatcacagt ctcagaccct   2280

ccctttgaca cccagccccg gcccgatgac agcttttcct gaggaccccg gccacgcagc   2340

tgttccccca catggacaga tggacacaca gagcctcggc ggccactgct ggcacggtgt   2400

gagcgccagg catctcccac ccgcccctcc cgacggccca accaggggct gtgcagacgt   2460

ggggaccacg gaaccgagat gcactttaga ccagggagct ggcccggcct ctggcaggcc   2520

ccccactaac ttattttgcc cggctgaggt tgtggggggc gcctcctggg gtgcacgatt   2580

ccctcagctc tgggtttaat gtattatatt tatttggggc cgacagtgcc ccaataaagg   2640

gtcagaagtg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2700

aaaaaaaaaa aaaaa                                                    2715


<210>  3753
<211>  724
<212>  PRT
<213>  Homosapiens

<400>  3753

Met Phe Asp Thr Thr Pro His Ser Gly Arg Ser Thr Pro Ser Ser Ser 
1               5                   10                  15      


Pro Ser Leu Arg Lys Arg Leu Gln Leu Leu Pro Pro Ser Arg Pro Pro 
            20                  25                  30          


Pro Glu Pro Glu Pro Gly Thr Met Val Glu Lys Gly Ser Asp Ser Ser 
        35                  40                  45              


Ser Glu Lys Gly Gly Val Pro Gly Thr Pro Ser Thr Gln Ser Leu Gly 
    50                  55                  60                  


Ser Arg Asn Phe Ile Arg Asn Ser Lys Lys Met Gln Ser Trp Tyr Ser 
65                  70                  75                  80  


Met Leu Ser Pro Thr Tyr Lys Gln Arg Asn Glu Asp Phe Arg Lys Leu 
                85                  90                  95      


Phe Ser Lys Leu Pro Glu Ala Glu Arg Leu Ile Val Asp Tyr Ser Cys 
            100                 105                 110         


Ala Leu Gln Arg Glu Ile Leu Leu Gln Gly Arg Leu Tyr Leu Ser Glu 
        115                 120                 125             


Asn Trp Ile Cys Phe Tyr Ser Asn Ile Phe Arg Trp Glu Thr Thr Ile 
    130                 135                 140                 


Ser Ile Gln Leu Lys Glu Val Thr Cys Leu Lys Lys Glu Lys Thr Ala 
145                 150                 155                 160 


Lys Leu Ile Pro Asn Ala Ile Gln Ile Cys Thr Glu Ser Glu Lys His 
                165                 170                 175     


Phe Phe Thr Ser Phe Gly Ala Arg Asp Arg Cys Phe Leu Leu Ile Phe 
            180                 185                 190         


Arg Leu Trp Gln Asn Ala Leu Leu Glu Lys Thr Leu Ser Pro Arg Glu 
        195                 200                 205             


Leu Trp His Leu Val His Gln Cys Tyr Gly Ser Glu Leu Gly Leu Thr 
    210                 215                 220                 


Ser Glu Asp Glu Asp Tyr Val Ser Pro Leu Gln Leu Asn Gly Leu Gly 
225                 230                 235                 240 


Thr Pro Lys Glu Val Gly Asp Val Ile Ala Leu Ser Asp Ile Thr Ser 
                245                 250                 255     


Ser Gly Ala Ala Asp Arg Ser Gln Glu Pro Ser Pro Val Gly Ser Arg 
            260                 265                 270         


Arg Gly His Val Thr Pro Asn Leu Ser Arg Ala Ser Ser Asp Ala Asp 
        275                 280                 285             


His Gly Ala Glu Glu Asp Lys Glu Glu Gln Val Asp Ser Gln Pro Asp 
    290                 295                 300                 


Ala Ser Ser Ser Gln Thr Val Thr Pro Val Ala Glu Pro Pro Ser Thr 
305                 310                 315                 320 


Glu Pro Thr Gln Pro Asp Gly Pro Thr Thr Leu Gly Pro Leu Asp Leu 
                325                 330                 335     


Leu Pro Ser Glu Glu Leu Leu Thr Asp Thr Ser Asn Ser Ser Ser Ser 
            340                 345                 350         


Thr Gly Glu Glu Ala Asp Leu Ala Ala Leu Leu Pro Asp Leu Ser Gly 
        355                 360                 365             


Arg Leu Leu Ile Asn Ser Val Phe His Val Gly Ala Glu Arg Leu Gln 
    370                 375                 380                 


Gln Met Leu Phe Ser Asp Ser Pro Phe Leu Gln Gly Phe Leu Gln Gln 
385                 390                 395                 400 


Cys Lys Phe Thr Asp Val Thr Leu Ser Pro Trp Ser Gly Asp Ser Lys 
                405                 410                 415     


Cys His Gln Arg Arg Val Leu Thr Tyr Thr Ile Pro Ile Ser Asn Pro 
            420                 425                 430         


Leu Gly Pro Lys Ser Ala Ser Val Val Glu Thr Gln Thr Leu Phe Arg 
        435                 440                 445             


Arg Gly Pro Gln Ala Gly Gly Cys Val Val Asp Ser Glu Val Leu Thr 
    450                 455                 460                 


Gln Gly Ile Pro Tyr Gln Asp Tyr Phe Tyr Thr Ala His Arg Tyr Cys 
465                 470                 475                 480 


Ile Leu Gly Leu Ala Arg Asn Lys Ala Arg Leu Arg Val Ser Ser Glu 
                485                 490                 495     


Ile Arg Tyr Arg Lys Gln Pro Trp Ser Leu Val Lys Ser Leu Ile Glu 
            500                 505                 510         


Lys Asn Ser Trp Ser Gly Ile Glu Asp Tyr Phe His His Leu Glu Arg 
        515                 520                 525             


Glu Leu Ala Lys Ala Glu Lys Leu Ser Leu Glu Glu Gly Gly Lys Asp 
    530                 535                 540                 


Ala Arg Gly Leu Leu Ser Gly Leu Arg Arg Arg Lys Arg Pro Leu Ser 
545                 550                 555                 560 


Trp Arg Ala His Gly Asp Gly Pro Gln His Pro Asp Pro Asp Pro Cys 
                565                 570                 575     


Ala Arg Ala Gly Ile His Thr Ser Gly Ser Leu Ser Ser Arg Phe Ser 
            580                 585                 590         


Glu Pro Ser Val Asp Gln Gly Pro Gly Ala Gly Ile Pro Ser Ala Leu 
        595                 600                 605             


Val Leu Ile Ser Ile Val Ile Cys Val Ser Leu Ile Ile Leu Ile Ala 
    610                 615                 620                 


Leu Asn Val Leu Leu Phe Tyr Arg Leu Trp Ser Leu Glu Arg Thr Ala 
625                 630                 635                 640 


His Thr Phe Glu Ser Trp His Ser Leu Ala Leu Ala Lys Gly Lys Phe 
                645                 650                 655     


Pro Gln Thr Ala Thr Glu Trp Ala Glu Ile Leu Ala Leu Gln Lys Gln 
            660                 665                 670         


Phe His Ser Val Glu Val His Lys Trp Arg Gln Ile Leu Arg Ala Ser 
        675                 680                 685             


Val Glu Leu Leu Asp Glu Met Lys Phe Ser Leu Glu Lys Leu His Gln 
    690                 695                 700                 


Gly Ile Thr Val Ser Asp Pro Pro Phe Asp Thr Gln Pro Arg Pro Asp 
705                 710                 715                 720 


Asp Ser Phe Ser 
                


<210>  3754
<211>  1521
<212>  DNA
<213>  Homosapiens

<400>  3754
gctgggcccc cggcggtaac cggagcgggg gggccgcgcc ccccctcctc ccccctcgcc     60

ggtcccagag ccgcagctgc tgcgcccgcg cgctcccggg gacattctaa ccgccgccag    120

gtcccgccgc ctctcgcccc gctattaata ccggcggccc gggagggggg cgcagcacgc    180

gccgcgcagc catggggagg ctgctggcct tagtggtcgg cgcggcactg gtgtcctcag    240

cctgcggggg ctgcgtggag gtggactcgg agaccgaggc cgtgtatggg atgaccttca    300

aaattctttg catctcctgc aagcgccgca gcgagaccaa cgctgagacc ttcaccgagt    360

ggaccttccg ccagaagggc actgaggagt ttgtcaagat cctgcgctat gagaatgagg    420

tgttgcagct ggaggaggat gagcgcttcg agggccgcgt ggtgtggaat ggcagccggg    480

gcaccaaaga cctgcaggat ctgtctatct tcatcaccaa tgtcacctac aaccactcgg    540

gcgactacga gtgccacgtc taccgcctgc tcttcttcga aaactacgag cacaacacca    600

gcgtcgtcaa gaagatccac attgaggtag tggacaaagc caacagagac atggcatcca    660

tcgtgtctga gatcatgatg tatgtgctca ttgtggtgtt gaccatatgg ctcgtggcag    720

agatgattta ctgctacaag aagatcgctg ccgccacgga gactgctgca caggagaatg    780

cctcggaata cctggccatc acctctgaaa gcaaagagaa ctgcacgggc gtccaggtgg    840

ccgaatagcc ctggccctgg gccccgcctc aaggaagagc cagccgtaat ggggactctc    900

caggcaccgc ctgcccccag cgtgggggtg gccactcctg ggccccagaa agcctcagag    960

tcctgccgac ggagccactg gggtgggagg gggcaggggg cttggctcgc acccccactt   1020

tcgcctcctc cagctcctgc cccgccggcc gcgcaccgcc atgcatgatg ggtaaagcaa   1080

tactgccgct gcccccaccc tgcttctgct gcctgtttgg ggaggggggc ggtgaggtgg   1140

gggcagcggc cccgcacccc tcctccttgc tgatttgcac acattggccg cttcagacac   1200

gcacttctgg ggccagcccc tccccgcctc ctccctgcct ggcggcaggg gtcgcgatga   1260

tgggctggag cagtttgggg cagggggttc tgggacccac tccgactccc cctccccggc   1320

atcatttccc ctcccgcttc ctccggctgg acctggggtc ccccctccct gtaatgcact   1380

cctgccccgg cccaacctcg ccctctctca ccagccttga actgtggcca cctagaaagg   1440

ggcccattca gcctcgtctc tttacagaag tagttttgtt catgaaataa agactcttgg   1500

acttgaaaaa aaaaaaaaaa a                                             1521


<210>  3755
<211>  218
<212>  PRT
<213>  Homosapiens

<400>  3755

Met Gly Arg Leu Leu Ala Leu Val Val Gly Ala Ala Leu Val Ser Ser 
1               5                   10                  15      


Ala Cys Gly Gly Cys Val Glu Val Asp Ser Glu Thr Glu Ala Val Tyr 
            20                  25                  30          


Gly Met Thr Phe Lys Ile Leu Cys Ile Ser Cys Lys Arg Arg Ser Glu 
        35                  40                  45              


Thr Asn Ala Glu Thr Phe Thr Glu Trp Thr Phe Arg Gln Lys Gly Thr 
    50                  55                  60                  


Glu Glu Phe Val Lys Ile Leu Arg Tyr Glu Asn Glu Val Leu Gln Leu 
65                  70                  75                  80  


Glu Glu Asp Glu Arg Phe Glu Gly Arg Val Val Trp Asn Gly Ser Arg 
                85                  90                  95      


Gly Thr Lys Asp Leu Gln Asp Leu Ser Ile Phe Ile Thr Asn Val Thr 
            100                 105                 110         


Tyr Asn His Ser Gly Asp Tyr Glu Cys His Val Tyr Arg Leu Leu Phe 
        115                 120                 125             


Phe Glu Asn Tyr Glu His Asn Thr Ser Val Val Lys Lys Ile His Ile 
    130                 135                 140                 


Glu Val Val Asp Lys Ala Asn Arg Asp Met Ala Ser Ile Val Ser Glu 
145                 150                 155                 160 


Ile Met Met Tyr Val Leu Ile Val Val Leu Thr Ile Trp Leu Val Ala 
                165                 170                 175     


Glu Met Ile Tyr Cys Tyr Lys Lys Ile Ala Ala Ala Thr Glu Thr Ala 
            180                 185                 190         


Ala Gln Glu Asn Ala Ser Glu Tyr Leu Ala Ile Thr Ser Glu Ser Lys 
        195                 200                 205             


Glu Asn Cys Thr Gly Val Gln Val Ala Glu 
    210                 215             


<210>  3756
<211>  1170
<212>  DNA
<213>  Homosapiens

<400>  3756
gctgggcccc cggcggtaac cggagcgggg gggccgcgcc ccccctcctc ccccctcgcc     60

ggtcccagag ccgcagctgc tgcgcccgcg cgctcccggg gacattctaa ccgccgccag    120

gtcccgccgc ctctcgcccc gctattaata ccggcggccc gggagggggg cgcagcacgc    180

gccgcgcagc catggggagg ctgctggcct tagtggtcgg cgcggcactg gtgtcctcag    240

cctgcggggg ctgcgtggag gtggactcgg agaccgaggc cgtgtatggg atgaccttca    300

aaattctttg catctcctgc aagcgccgca gcgagaccaa cgctgagacc ttcaccgagt    360

ggaccttccg ccagaagggc actgaggagt ttgtcaagat cctgcgctat gagaatgagg    420

tgttgcagct ggaggaggat gagcgcttcg agggccgcgt ggtgtggaat ggcagccggg    480

gcaccaaaga cctgcaggat ctgtctatct tcatcaccaa tgtcacctac aaccactcgg    540

gcgactacga gtgccacgtc taccgcctgc tcttcttcga aaactacgag cacaacacca    600

gcgtcgtcaa gaagatccac attgaggtag tggacaaagg tgagtcgggt gctgcctgcc    660

cctttaccgt cacccaccgg agagccagat ggagggacag atggcaggca gtggacagga    720

caggctggct ctgtgcctgg ccagccaacc gcccacagca gcgggctgag ggggagggga    780

gcagcccctc ctgcccactc cagctctggc ctctgtttct ctccagccca cggagaggtc    840

aaagcatgcc tgtcccccac agacgctccg ggtacagaac ccagctctgt cacctgtgct    900

gtatgacctc tggcaggtgc cttctgtctc tgagccaaag ggttgtcctg ggcttgcccg    960

ggataataat ccgatgtgtt tctcggggtg tggtttgagc cattcttcca tcatggggtt   1020

catgaggatt gagcagctgc aggcacacgc ctggcttcca gcagagcctt gcaggtggtg   1080

gcgagggtgg cggttcttac tgttcgagta gctcagccct gctgccctct gtggtgatga   1140

ggcaagagag cgtgccacct agagcagagt                                    1170


<210>  3757
<211>  268
<212>  PRT
<213>  Homosapiens

<400>  3757

Met Gly Arg Leu Leu Ala Leu Val Val Gly Ala Ala Leu Val Ser Ser 
1               5                   10                  15      


Ala Cys Gly Gly Cys Val Glu Val Asp Ser Glu Thr Glu Ala Val Tyr 
            20                  25                  30          


Gly Met Thr Phe Lys Ile Leu Cys Ile Ser Cys Lys Arg Arg Ser Glu 
        35                  40                  45              


Thr Asn Ala Glu Thr Phe Thr Glu Trp Thr Phe Arg Gln Lys Gly Thr 
    50                  55                  60                  


Glu Glu Phe Val Lys Ile Leu Arg Tyr Glu Asn Glu Val Leu Gln Leu 
65                  70                  75                  80  


Glu Glu Asp Glu Arg Phe Glu Gly Arg Val Val Trp Asn Gly Ser Arg 
                85                  90                  95      


Gly Thr Lys Asp Leu Gln Asp Leu Ser Ile Phe Ile Thr Asn Val Thr 
            100                 105                 110         


Tyr Asn His Ser Gly Asp Tyr Glu Cys His Val Tyr Arg Leu Leu Phe 
        115                 120                 125             


Phe Glu Asn Tyr Glu His Asn Thr Ser Val Val Lys Lys Ile His Ile 
    130                 135                 140                 


Glu Val Val Asp Lys Gly Glu Ser Gly Ala Ala Cys Pro Phe Thr Val 
145                 150                 155                 160 


Thr His Arg Arg Ala Arg Trp Arg Asp Arg Trp Gln Ala Val Asp Arg 
                165                 170                 175     


Thr Gly Trp Leu Cys Ala Trp Pro Ala Asn Arg Pro Gln Gln Arg Ala 
            180                 185                 190         


Glu Gly Glu Gly Ser Ser Pro Ser Cys Pro Leu Gln Leu Trp Pro Leu 
        195                 200                 205             


Phe Leu Ser Ser Pro Arg Arg Gly Gln Ser Met Pro Val Pro His Arg 
    210                 215                 220                 


Arg Ser Gly Tyr Arg Thr Gln Leu Cys His Leu Cys Cys Met Thr Ser 
225                 230                 235                 240 


Gly Arg Cys Leu Leu Ser Leu Ser Gln Arg Val Val Leu Gly Leu Pro 
                245                 250                 255     


Gly Ile Ile Ile Arg Cys Val Ser Arg Gly Val Val 
            260                 265             


<210>  3758
<211>  1783
<212>  DNA
<213>  Homosapiens

<400>  3758
tcgagcccgc tttccaggga ccctacctga gggcccacag gtgaggcagc ctggcctagc     60

aggccccacg ccaccgcctc tgcctccagg ccgcccgctg ctgcggggcc accatgctcc    120

tgcccaggcc tggagactga cccgaccccg gcactacctc gaggctccgc ccccacctgc    180

tggaccccag ggtcccaccc tggcccagga ggtcagccag ggaatcatta acaagaggca    240

gtgacatggc gcagaaggag ggtggccgga ctgtgccatg ctgctccaga cccaaggtgg    300

cagctctcac tgcggggacc ctgctacttc tgacagccat cggggcggca tcctgggcca    360

ttgtggctgt tctcctcagg agtgaccagg agccgctgta cccagtgcag gtcagctctg    420

cggacgctcg gctcatggtc tttgacaaga cggaagggac gtggcggctg ctgtgctcct    480

cgcgctccaa cgccagggta gccggactca gctgcgagga gatgggcttc ctcagggcac    540

tgacccactc cgagctggac gtgcgaacgg cgggcgccaa tggcacgtcg ggcttcttct    600

gtgtggacga ggggaggctg ccccacaccc agaggctgct ggaggtcatc tccgtgtgtg    660

attgccccag aggccgtttc ttggccgcca tctgccaaga ctgtggccgc aggaagctgc    720

ccgtggaccg catcgtggga ggccgggaca ccagcttggg ccggtggccg tggcaagtca    780

gccttcgcta tgatggagca cacctctgtg ggggatccct gctctccggg gactgggtgc    840

tgacagccgc ccactgcttc ccggagcgga accgggtcct gtcccgatgg cgagtgtttg    900

ccggtgccgt ggcccaggcc tctccccacg gtctgcagct gggggtgcag gctgtggtct    960

accacggggg ctatcttccc tttcgggacc ccaacagcga ggagaacagc aacgatattg   1020

ccctggtcca cctctccagt cccctgcccc tcacagaata catccagcct gtgtgcctcc   1080

cagctgccgg ccaggccctg gtggatggca agatctgtac cgtgacgggc tggggcaaca   1140

cgcagtacta tggccaacag gccggggtac tccaggaggc tcgagtcccc ataatcagca   1200

atgatgtctg caatggcgct gacttctatg gaaaccagat caagcccaag atgttctgtg   1260

ctggctaccc cgagggtggc attgatgcct gccagggcga cagcggtggt ccctttgtgt   1320

gtgaggacag catctctcgg acgccacgtt ggcggctgtg tggcattgtg agttggggca   1380

ctggctgtgc cctggcccag aagccaggcg tctacaccaa agtcagtgac ttccgggagt   1440

ggatcttcca ggccataaag actcactccg aagccagcgg catggtgacc cagctctgac   1500

cggtggcttc tcgctgcgca gcctccaggg cccgaggtga tcccggtggt gggatccacg   1560

ctgggccgag gatgggacgt ttttcttctt gggcccggtc cacaggtcca aggacaccct   1620

ccctccaggg tcctctcttc cacagtggcg ggcccactca gccccgagac cacccaacct   1680

caccctcctg acccccatgt aaatattgtt ctgctgtctg ggactcctgt ctaggtgccc   1740

ctgatgatgg gatgctcttt aaataataaa gatggttttg att                     1783


<210>  3759
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  3759

Met Ala Gln Lys Glu Gly Gly Arg Thr Val Pro Cys Cys Ser Arg Pro 
1               5                   10                  15      


Lys Val Ala Ala Leu Thr Ala Gly Thr Leu Leu Leu Leu Thr Ala Ile 
            20                  25                  30          


Gly Ala Ala Ser Trp Ala Ile Val Ala Val Leu Leu Arg Ser Asp Gln 
        35                  40                  45              


Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met 
    50                  55                  60                  


Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg 
65                  70                  75                  80  


Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu 
                85                  90                  95      


Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn 
            100                 105                 110         


Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr 
        115                 120                 125             


Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg 
    130                 135                 140                 


Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys Leu Pro Val 
145                 150                 155                 160 


Asp Arg Ile Val Gly Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp 
                165                 170                 175     


Gln Val Ser Leu Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu 
            180                 185                 190         


Leu Ser Gly Asp Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg 
        195                 200                 205             


Asn Arg Val Leu Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln 
    210                 215                 220                 


Ala Ser Pro His Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His 
225                 230                 235                 240 


Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn 
                245                 250                 255     


Asp Ile Ala Leu Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr 
            260                 265                 270         


Ile Gln Pro Val Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly 
        275                 280                 285             


Lys Ile Cys Thr Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln 
    290                 295                 300                 


Gln Ala Gly Val Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp 
305                 310                 315                 320 


Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met 
                325                 330                 335     


Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp 
            340                 345                 350         


Ser Gly Gly Pro Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg 
        355                 360                 365             


Trp Arg Leu Cys Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala 
    370                 375                 380                 


Gln Lys Pro Gly Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile 
385                 390                 395                 400 


Phe Gln Ala Ile Lys Thr His Ser Glu Ala Ser Gly Met Val Thr Gln 
                405                 410                 415     


Leu 
    


<210>  3760
<211>  2363
<212>  DNA
<213>  Homosapiens

<400>  3760
tcgagcccgc tttccaggga ccctacctga gggcccacag gtgaggcagc ctggcctagc     60

aggccccacg ccaccgcctc tgcctccagg ccgcccgctg ctgcggggcc accatgctcc    120

tgcccaggcc tggagactga cccgaccccg gcactacctc gaggctccgc ccccacctgc    180

tggaccccag ggtaaggaca agggccccca gactcacagt tccagccctg aggacagggg    240

ttccctcatc cccccaccca gcctaatgcc cacctcctaa tagaggggtt cctggggacc    300

tgaagagggg gcactatgac gtctccccaa gcacctaggt gttctgtcct gctcttcctt    360

cagactcagc cgttggaccc cagtcctttc ctccccagac ccaggagttc cagccctcag    420

gcccctcctc cctcatacta gggagtcctg gcccccaaat tcctcctttc ccaagactta    480

tgatttcagg tcctcagctg tctcctccct caaaccggga tcctcagtcc cctgctccac    540

caggctcagg catgggggtc cccatccctg caaatccagg cgtccccccg ctgctggtca    600

gacactgacc ccatccttga acccagccca atctgcgtcc gtgatcacgg cgtgctctgg    660

ccaaggccca gtccctacag cctgcctgga tggacgcctg ggactggggg cgccaggact    720

gggctgggct gggctccccc aggccctgcc tccccgtcca tctcctcaca ggtcccaccc    780

tggcccagga ggtcagccag ggaatcatta acaagaggca gtgacatggc gcagaaggag    840

ggtggccgga ctgtgccatg ctgctccaga cccaaggtgg cagctctcac tgcggggacc    900

ctgctacttc tgacagccat cggggcggca tcctgggcca ttgtggctgt tctcctcagg    960

agtgaccagg agccgctgta cccagtgcag gtcagctctg cggacgctcg gctcatggtc   1020

tttgacaaga cggaagggac gtggcggctg ctgtgctcct cgcgctccaa cgccagggta   1080

gccggactca gctgcgagga gatgggcttc ctcagggcac tgacccactc cgagctggac   1140

gtgcgaacgg cgggcgccaa tggcacgtcg ggcttcttct gtgtggacga ggggaggctg   1200

ccccacaccc agaggctgct ggaggtcatc tccgtgtgtg attgccccag aggccgtttc   1260

ttggccgcca tctgccaaga ctgtggccgc aggaagctgc ccgtggaccg catcgtggga   1320

ggccgggaca ccagcttggg ccggtggccg tggcaagtca gccttcgcta tgatggagca   1380

cacctctgtg ggggatccct gctctccggg gactgggtgc tgacagccgc ccactgcttc   1440

ccggagcgga accgggtcct gtcccgatgg cgagtgtttg ccggtgccgt ggcccaggcc   1500

tctccccacg gtctgcagct gggggtgcag gctgtggtct accacggggg ctatcttccc   1560

tttcgggacc ccaacagcga ggagaacagc aacgatattg ccctggtcca cctctccagt   1620

cccctgcccc tcacagaata catccagcct gtgtgcctcc cagctgccgg ccaggccctg   1680

gtggatggca agatctgtac cgtgacgggc tggggcaaca cgcagtacta tggccaacag   1740

gccggggtac tccaggaggc tcgagtcccc ataatcagca atgatgtctg caatggcgct   1800

gacttctatg gaaaccagat caagcccaag atgttctgtg ctggctaccc cgagggtggc   1860

attgatgcct gccagggcga cagcggtggt ccctttgtgt gtgaggacag catctctcgg   1920

acgccacgtt ggcggctgtg tggcattgtg agttggggca ctggctgtgc cctggcccag   1980

aagccaggcg tctacaccaa agtcagtgac ttccgggagt ggatcttcca ggccataaag   2040

actcactccg aagccagcgg catggtgacc cagctctgac cggtggcttc tcgctgcgca   2100

gcctccaggg cccgaggtga tcccggtggt gggatccacg ctgggccgag gatgggacgt   2160

ttttcttctt gggcccggtc cacaggtcca aggacaccct ccctccaggg tcctctcttc   2220

cacagtggcg ggcccactca gccccgagac cacccaacct caccctcctg acccccatgt   2280

aaatattgtt ctgctgtctg ggactcctgt ctaggtgccc ctgatgatgg gatgctcttt   2340

aaataataaa gatggttttg att                                           2363


<210>  3761
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  3761

Met Ala Gln Lys Glu Gly Gly Arg Thr Val Pro Cys Cys Ser Arg Pro 
1               5                   10                  15      


Lys Val Ala Ala Leu Thr Ala Gly Thr Leu Leu Leu Leu Thr Ala Ile 
            20                  25                  30          


Gly Ala Ala Ser Trp Ala Ile Val Ala Val Leu Leu Arg Ser Asp Gln 
        35                  40                  45              


Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met 
    50                  55                  60                  


Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg 
65                  70                  75                  80  


Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu 
                85                  90                  95      


Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn 
            100                 105                 110         


Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr 
        115                 120                 125             


Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg 
    130                 135                 140                 


Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys Leu Pro Val 
145                 150                 155                 160 


Asp Arg Ile Val Gly Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp 
                165                 170                 175     


Gln Val Ser Leu Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu 
            180                 185                 190         


Leu Ser Gly Asp Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg 
        195                 200                 205             


Asn Arg Val Leu Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln 
    210                 215                 220                 


Ala Ser Pro His Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His 
225                 230                 235                 240 


Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn 
                245                 250                 255     


Asp Ile Ala Leu Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr 
            260                 265                 270         


Ile Gln Pro Val Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly 
        275                 280                 285             


Lys Ile Cys Thr Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln 
    290                 295                 300                 


Gln Ala Gly Val Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp 
305                 310                 315                 320 


Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met 
                325                 330                 335     


Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp 
            340                 345                 350         


Ser Gly Gly Pro Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg 
        355                 360                 365             


Trp Arg Leu Cys Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala 
    370                 375                 380                 


Gln Lys Pro Gly Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile 
385                 390                 395                 400 


Phe Gln Ala Ile Lys Thr His Ser Glu Ala Ser Gly Met Val Thr Gln 
                405                 410                 415     


Leu 
    


<210>  3762
<211>  1433
<212>  DNA
<213>  Homosapiens

<400>  3762
gtaaactgaa ctggggctgg gcaacaggaa aaaagaagaa accacagatt agagaaatct     60

cggcggtcag gaggcccggg gtctaagatg taaagaggta aacagattta gggattgatt    120

gtctgctggg gtgggttgag aggagaaaag ggaagaaaag tcgggggact acgtcctcag    180

acctgacctg agtggtgaga ggtggaccca ggaggagtgg caggtggtgg cggggttttg    240

cagagctcag ttggaggccc tctccgaggc agcttgatgg aacgtgggag agccgggctg    300

gagtcacagt ttttattttg ctagggaggt agtcagtggc gcacaaaggg taacaagcag    360

tgatagtggg gatgctttcc attttaggaa acttttccta aaaggaagtg gcaattttaa    420

ctaatctccc ctccgccgct cccagctgcc gctccagatg ctgctgctgc cgccgcggcc    480

accccaccct cggtcctcct ctccggaggc catggaccca ccgcccccca aggctccccc    540

tttccccaag gcggaaggcc cctcctccac tccttcctcg gcggcggggc cccgaccccc    600

gcggctgggc cgccacctcc tcatcgacgc caatggggtc ccctacacat acacggtgca    660

gctggaggag gagccccggg gcccgcccca gcgcgaggcg cccccaggag agcccggccc    720

tcgcaagggc tacagctgcc cggagtgcgc ccgtgtcttt gccagccctc tgcggctgca    780

gagccaccgc gtgtcgcact cggacctcaa gcccttcacg tgcggcgcct gcggcaaggc    840

cttcaagcgc tccagccacc tgtcgcggca tcgcgccacg caccgcgccc gcgccgggcc    900

gccgcacacc tgcccgctct gcccacgccg cttccaggac gccgcggagc tggcgcagca    960

cgtgcgcctc cactaagctc gagacccggc ctgtgctgcc ctgcccgtct cagggccacc   1020

aagtctgacc cacacagcgt cactcactcc cacacacacc ccctggctct gctgaggtta   1080

ctgccttacc ctgggcctca gtttccccac cttccaaagg gaggagcatc attccttcct   1140

tacccccttt ctagctgtgt gatgtagacc aaagtcgttg cccctccctg ggcctgggaa   1200

ccagtcggaa ctgggttcca gtccagctgt gctgtgtgag cctgtgcaag tgacatgacc   1260

tctctaaacc ttggttttct gctctctgga gcggtgaacc ggtggttgtc tgcggggaag   1320

agatgataaa gagcacgggc acggtctggt tcatttctgt atctaccccc cttccgccca   1380

cgcccccgac cctttgctca ataaacattc cgcactccaa aaaaaaaaaa aaa          1433


<210>  3763
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  3763

Met Leu Leu Leu Pro Pro Arg Pro Pro His Pro Arg Ser Ser Ser Pro 
1               5                   10                  15      


Glu Ala Met Asp Pro Pro Pro Pro Lys Ala Pro Pro Phe Pro Lys Ala 
            20                  25                  30          


Glu Gly Pro Ser Ser Thr Pro Ser Ser Ala Ala Gly Pro Arg Pro Pro 
        35                  40                  45              


Arg Leu Gly Arg His Leu Leu Ile Asp Ala Asn Gly Val Pro Tyr Thr 
    50                  55                  60                  


Tyr Thr Val Gln Leu Glu Glu Glu Pro Arg Gly Pro Pro Gln Arg Glu 
65                  70                  75                  80  


Ala Pro Pro Gly Glu Pro Gly Pro Arg Lys Gly Tyr Ser Cys Pro Glu 
                85                  90                  95      


Cys Ala Arg Val Phe Ala Ser Pro Leu Arg Leu Gln Ser His Arg Val 
            100                 105                 110         


Ser His Ser Asp Leu Lys Pro Phe Thr Cys Gly Ala Cys Gly Lys Ala 
        115                 120                 125             


Phe Lys Arg Ser Ser His Leu Ser Arg His Arg Ala Thr His Arg Ala 
    130                 135                 140                 


Arg Ala Gly Pro Pro His Thr Cys Pro Leu Cys Pro Arg Arg Phe Gln 
145                 150                 155                 160 


Asp Ala Ala Glu Leu Ala Gln His Val Arg Leu His 
                165                 170         


<210>  3764
<211>  1152
<212>  DNA
<213>  Homosapiens

<400>  3764
cccctcgcac ccccgcgccc ccagtccccg cgtccccggc gccgccggcc cggagctgcc     60

cggaagtctc ggttccgccg ccggcgctcg ccaggggaag cccggggccg cccgggacct    120

cggcccgttc ctccggaccc gagaggccgc cgcacgggct gccgctccag atgctgctgc    180

tgccgccgcg gccaccccac cctcggtcct cctctccgga ggccatggac ccaccgcccc    240

ccaaggctcc ccctttcccc aaggcggaag gcccctcctc cactccttcc tcggcggcgg    300

ggccccgacc cccgcggctg ggccgccacc tcctcatcga cgccaatggg gtcccctaca    360

catacacggt gcagctggag gaggagcccc ggggcccgcc ccagcgcgag gcgcccccag    420

gagagcccgg ccctcgcaag ggctacagct gcccggagtg cgcccgtgtc tttgccagcc    480

ctctgcggct gcagagccac cgcgtgtcgc actcggacct caagcccttc acgtgcggcg    540

cctgcggcaa ggccttcaag cgctccagcc acctgtcgcg gcatcgcgcc acgcaccgcg    600

cccgcgccgg gccgccgcac acctgcccgc tctgcccacg ccgcttccag gacgccgcgg    660

agctggcgca gcacgtgcgc ctccactaag ctcgagaccc ggcctgtgct gccctgcccg    720

tctcagggcc accaagtctg acccacacag cgtcactcac tcccacacac accccctggc    780

tctgctgagg ttactgcctt accctgggcc tcagtttccc caccttccaa agggaggagc    840

atcattcctt ccttaccccc tttctagctg tgtgatgtag accaaagtcg ttgcccctcc    900

ctgggcctgg gaaccagtcg gaactgggtt ccagtccagc tgtgctgtgt gagcctgtgc    960

aagtgacatg acctctctaa accttggttt tctgctctct ggagcggtga accggtggtt   1020

gtctgcgggg aagagatgat aaagagcacg ggcacggtct ggttcatttc tgtatctacc   1080

ccccttccgc ccacgccccc gaccctttgc tcaataaaca ttccgcactc caaaaaaaaa   1140

aaaaaaaaaa aa                                                       1152


<210>  3765
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  3765

Met Leu Leu Leu Pro Pro Arg Pro Pro His Pro Arg Ser Ser Ser Pro 
1               5                   10                  15      


Glu Ala Met Asp Pro Pro Pro Pro Lys Ala Pro Pro Phe Pro Lys Ala 
            20                  25                  30          


Glu Gly Pro Ser Ser Thr Pro Ser Ser Ala Ala Gly Pro Arg Pro Pro 
        35                  40                  45              


Arg Leu Gly Arg His Leu Leu Ile Asp Ala Asn Gly Val Pro Tyr Thr 
    50                  55                  60                  


Tyr Thr Val Gln Leu Glu Glu Glu Pro Arg Gly Pro Pro Gln Arg Glu 
65                  70                  75                  80  


Ala Pro Pro Gly Glu Pro Gly Pro Arg Lys Gly Tyr Ser Cys Pro Glu 
                85                  90                  95      


Cys Ala Arg Val Phe Ala Ser Pro Leu Arg Leu Gln Ser His Arg Val 
            100                 105                 110         


Ser His Ser Asp Leu Lys Pro Phe Thr Cys Gly Ala Cys Gly Lys Ala 
        115                 120                 125             


Phe Lys Arg Ser Ser His Leu Ser Arg His Arg Ala Thr His Arg Ala 
    130                 135                 140                 


Arg Ala Gly Pro Pro His Thr Cys Pro Leu Cys Pro Arg Arg Phe Gln 
145                 150                 155                 160 


Asp Ala Ala Glu Leu Ala Gln His Val Arg Leu His 
                165                 170         


<210>  3766
<211>  1258
<212>  DNA
<213>  Homosapiens

<400>  3766
ctagaccctc ttctctccct tcggcttctc tctttcggcc ggcgccgcca gttcctgggg     60

cacacccaga ggtccccttc tcgccgccgc ctgcaactgc gagggtagcc cggggccgct    120

tggagtcgcc cggacctgag aggctgctgc actgggcctc agccagccct ccggatgctg    180

gtgctgccat ccccctgccc tcagcctctg gcattttcct ccgttgagac catggagggc    240

cctccccgtc ggacttgccg ctccccagaa cctggacctt cctcctccat cggatctccc    300

caggcttcat ctcctccaag gcccaaccac tacctgctta ttgacactca gggtgtcccc    360

tacacagtgc tggtggacga ggagtcacag agggagccag gggccagtgg ggctccaggc    420

cagaaaaagt gctacagctg ccccgtgtgc tcaagggtct tcgagtacat gtcctacctt    480

cagcgacaca gcatcaccca ctcggaggta aagcccttcg agtgtgacat ctgtgggaag    540

gcattcaagc gcgccagcca cttggcacgg caccattcca ttcacctggc gggtggtggg    600

cggccccacg gctgcccgct ctgccctcgc cgcttccggg atgcgggtga gctggcccag    660

cacagccggg tgcactctgg ggaacgcccg tttcagtgtc cacactgccc tcgccgcttt    720

atggagcaga acacactgca gaaacacacg cggtggaagc atccatgagc cgggctgccg    780

ggtgccccag gtaccacagg actttgcagg gagcctggac tcctgtccag acacctggtg    840

agagcctgag gctggtgttc agggccctgg acacagacac agagcagccg catctcaaag    900

gcagagccct gcctgaagga ggaatccgtg agtaatcttc aggtcctccg tgttctggag    960

ctgagatggg aatgagcccc tacacagaat ggagtcctct agcctaaaga tatcagctgt   1020

tccatggcag agccttgact ggatggaggt ggggagtgtg gtgtgtaaag tctctggcct   1080

cataaaaggt ggctgtgggt cgtcaggaat ctgcgccatc ttcctggggc ttctgcgctg   1140

ttgttgggga agggacccca gtcctgcctt ccacccccca accaggcctg agactgatca   1200

aacaataaac acgtttccca ctctgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa     1258


<210>  3767
<211>  197
<212>  PRT
<213>  Homosapiens

<400>  3767

Met Leu Val Leu Pro Ser Pro Cys Pro Gln Pro Leu Ala Phe Ser Ser 
1               5                   10                  15      


Val Glu Thr Met Glu Gly Pro Pro Arg Arg Thr Cys Arg Ser Pro Glu 
            20                  25                  30          


Pro Gly Pro Ser Ser Ser Ile Gly Ser Pro Gln Ala Ser Ser Pro Pro 
        35                  40                  45              


Arg Pro Asn His Tyr Leu Leu Ile Asp Thr Gln Gly Val Pro Tyr Thr 
    50                  55                  60                  


Val Leu Val Asp Glu Glu Ser Gln Arg Glu Pro Gly Ala Ser Gly Ala 
65                  70                  75                  80  


Pro Gly Gln Lys Lys Cys Tyr Ser Cys Pro Val Cys Ser Arg Val Phe 
                85                  90                  95      


Glu Tyr Met Ser Tyr Leu Gln Arg His Ser Ile Thr His Ser Glu Val 
            100                 105                 110         


Lys Pro Phe Glu Cys Asp Ile Cys Gly Lys Ala Phe Lys Arg Ala Ser 
        115                 120                 125             


His Leu Ala Arg His His Ser Ile His Leu Ala Gly Gly Gly Arg Pro 
    130                 135                 140                 


His Gly Cys Pro Leu Cys Pro Arg Arg Phe Arg Asp Ala Gly Glu Leu 
145                 150                 155                 160 


Ala Gln His Ser Arg Val His Ser Gly Glu Arg Pro Phe Gln Cys Pro 
                165                 170                 175     


His Cys Pro Arg Arg Phe Met Glu Gln Asn Thr Leu Gln Lys His Thr 
            180                 185                 190         


Arg Trp Lys His Pro 
        195         


<210>  3768
<211>  1993
<212>  DNA
<213>  Homosapiens

<400>  3768
ggctggggag gagcaggaac agtcaggact ggaatctagc tttgctccaa agccagctct     60

taattaccaa catggggatg ggggtggcgt gttcctggcc ctcattttcc gggagagggg    120

taactccccc gattttggcc cccacatccc tgagaacctt ggggtctggc tgtaggaggt    180

aggggagctc tgaggggtcc gcgctggcta gttcctgaga gagcgttaaa agtagattct    240

cctttcgctc caactttctc ggtgtctcaa acactctcct gccttctggg cccattgggc    300

acaccgccac ccaatccggg gacccccgga gactcgccag ctctccagga tgggaatttc    360

gtgatgttcc ctgcctgagc ttcggggagg gcgggggagt gctgtaaggg gctatcgcgc    420

aagtgcagac cctctgcttc tgccgcaaac ggcgggcctc acctggaccc ggggactctt    480

caacgagggg cgctagcctg gcccgactgg gcgagtcccc gcgtccctgc ccgttccgtc    540

gctcagttcc acgacacgct cccctgccgc cccgcctgtt cgcgggtggg tgggcgcttc    600

cctcggctcc ccgtgacact ttgcagacgc tccccggcgc cgggcatggg cgccgccgcc    660

gtcggtcccc gagccggatt ccgcgagcgg tgcccctgag gccctcggct gctggggtcc    720

gtaggaagcc gcgccatgaa tgaccggagc agtcggaggc ggacaatgaa ggacgatgag    780

accttcgaga tctccattcc cttcgatgag gcaccccacc tagacccaca gatcttttac    840

agtctgagcc cctctcggag aaacttcgag gagcctccgg aggctgcgtc ctccgccctg    900

gctctgatga acagcgtcaa gacccagctg cacatggctc tggagaggaa ctcctggctg    960

cagaagcgca tcgaggacct ggaggaagag agggacttcc tgcggtgcca gctggacaaa   1020

ttcatctctt ctgctcggat ggaggcagag gaccactgcc ggatgaagcc tgggcccagg   1080

cggatggagg gggacagccg tggtggggct gggggcgagg cctcggaccc tgagtcagca   1140

gcctcctccc tcagcggagc gtccgaagaa ggcagcgcca gtgagaggag gcggcagaag   1200

cagaagggag gtgctagtcg gaggcgcttt gggaagccca aggcccggga gaggcagcga   1260

gtgaaggacg ccgacggggt cctctgccgg tacaagaaga tcctgggcac cttccagaag   1320

ctcaagagca tgtcgcgggc cttcgagcac caccgcgtgg acaggaacac cgtggcgctg   1380

accacgccca tcgccgagct gctcattgtg gcccccgaga agctggccga ggtgggcgag   1440

ttcgacccct ccaaggagcg cctgctcgag tactcccgcc gctgctttct ggccctggac   1500

gacgagacgc tcaagaaggt gcaggcgctc aagaagagca agctgctgct gcccatcacc   1560

taccgcttca agcggtgatc gcaccacgcc tccgcgcctc cacccgggcc ttcctccccc   1620

gtggaccccg gtggatgacc tgcccctctc cccgccgcgc ccctgcccct cctcctcgct   1680

ccctgggttg ggggctccct tagccgggcc cccaagcgcg acggccccgg accggccgcg   1740

gccccttccc gaacgccggc acccccttcc gcttgggctg cccagccctg tcctcgccgg   1800

gccccttcct cctggaaaac caggcaggcg ggtgcccccc cctcgagtgg gggactgtac   1860

agaccccgtc tccgccctgg ccccgcggag gagctgccca cctgattccc ggacagacct   1920

ccccaactcc gcgtgagaca gagaattatt cagataattt aaattaaaaa acgacgtgaa   1980

aatttggaat aaa                                                      1993


<210>  3769
<211>  280
<212>  PRT
<213>  Homosapiens

<400>  3769

Met Asn Asp Arg Ser Ser Arg Arg Arg Thr Met Lys Asp Asp Glu Thr 
1               5                   10                  15      


Phe Glu Ile Ser Ile Pro Phe Asp Glu Ala Pro His Leu Asp Pro Gln 
            20                  25                  30          


Ile Phe Tyr Ser Leu Ser Pro Ser Arg Arg Asn Phe Glu Glu Pro Pro 
        35                  40                  45              


Glu Ala Ala Ser Ser Ala Leu Ala Leu Met Asn Ser Val Lys Thr Gln 
    50                  55                  60                  


Leu His Met Ala Leu Glu Arg Asn Ser Trp Leu Gln Lys Arg Ile Glu 
65                  70                  75                  80  


Asp Leu Glu Glu Glu Arg Asp Phe Leu Arg Cys Gln Leu Asp Lys Phe 
                85                  90                  95      


Ile Ser Ser Ala Arg Met Glu Ala Glu Asp His Cys Arg Met Lys Pro 
            100                 105                 110         


Gly Pro Arg Arg Met Glu Gly Asp Ser Arg Gly Gly Ala Gly Gly Glu 
        115                 120                 125             


Ala Ser Asp Pro Glu Ser Ala Ala Ser Ser Leu Ser Gly Ala Ser Glu 
    130                 135                 140                 


Glu Gly Ser Ala Ser Glu Arg Arg Arg Gln Lys Gln Lys Gly Gly Ala 
145                 150                 155                 160 


Ser Arg Arg Arg Phe Gly Lys Pro Lys Ala Arg Glu Arg Gln Arg Val 
                165                 170                 175     


Lys Asp Ala Asp Gly Val Leu Cys Arg Tyr Lys Lys Ile Leu Gly Thr 
            180                 185                 190         


Phe Gln Lys Leu Lys Ser Met Ser Arg Ala Phe Glu His His Arg Val 
        195                 200                 205             


Asp Arg Asn Thr Val Ala Leu Thr Thr Pro Ile Ala Glu Leu Leu Ile 
    210                 215                 220                 


Val Ala Pro Glu Lys Leu Ala Glu Val Gly Glu Phe Asp Pro Ser Lys 
225                 230                 235                 240 


Glu Arg Leu Leu Glu Tyr Ser Arg Arg Cys Phe Leu Ala Leu Asp Asp 
                245                 250                 255     


Glu Thr Leu Lys Lys Val Gln Ala Leu Lys Lys Ser Lys Leu Leu Leu 
            260                 265                 270         


Pro Ile Thr Tyr Arg Phe Lys Arg 
        275                 280 


<210>  3770
<211>  3136
<212>  DNA
<213>  Homosapiens

<400>  3770
ggagagcgcg ccacagaacg acttttacgc aggcgcagaa gcctgtttcc cctcacccgc     60

ggcttccacc ctgcgcaggc gcaaaaagcc gcgctggcaa cctccgcagc ggtcgcgcgc    120

acccttcacc cctcttgctg cttttgtctg gcacaacctt ctcaggccct ccgcgaggcc    180

ggcccttttt ttctttcact ttccccaccc ggagagccag gtgccgagaa ctaggacctc    240

gtccccttct ctatcccttc ccctgatcca tctcgtctct gttctccttc ccttttccgt    300

tcccgaagcc ggaaggagcc gaggtaccca cggaaaaagt cgaagctgtc cccggagagt    360

gaggccttca cgaagcggtg gcggaaggag ccgaagttct ctgatcggag gcgtgagcaa    420

gtggcatctc cggaaagagc cgaaacacgg actcgagctt aatcccagga ggggcccgag    480

ggcgagatcc ggaaatctcc ggaaagagcc gaaggccggg acggttagga ttgtcggaag    540

tggccgattg cttggacagg gccggcggag aagatcggag caagtccgtg gaagaagcca    600

aagactggga cggattgaat tgttggaaga acccgaactc gcagagggga ctgggcgcag    660

tggcacacga ggacacacgg aaacctccga acgttgagga gataatctcg gaaaagttac    720

ggaaacctgg gaagtcggcg aaaccctacg ttcgggtgtt ttcggaagca gccgaagcgg    780

ccgcctgctt cgccttcgtc cagtatccgg agatagccga ggcgcttcgg agccaggctc    840

ggggggaggg gcaagctcgc gggcgggcgg gcgggtgagg gggcggagcc cgggcggggc    900

ggggagggct gccggaggct tgattaggta ggaggtggcg aagcgccggc ggcggccgga    960

agtagccgaa gccagcggcg gaagtagccg aagcggctgg agcgggcggc aaggcgaggc   1020

gaaagctgca cagggcccta cgcggccgcc tcagcatgtc ggacttcgac gagttcgagc   1080

ggcagctcaa cgagaataaa caagagcggg acaaggagaa ccggcatcgg aagcgcagcc   1140

acagccgctc tcggagccgg gaccgcaaac gccggagccg gagccgcgac cggcgcaacc   1200

gggaccagcg gagcgcctcc cgggacaggc gacgacgcag caaacctttg accagaggcg   1260

ctaaagagga gcacggtgga ctgattcgtt ccccccgcca cgagaagaag aagaaggtcc   1320

gtaaatactg ggacgtgcca cccccaggct ttgagcacat caccccaatg cagtacaagg   1380

ccatgcaagc tgcgggtcag attccagcca ctgctcttct ccccaccatg acccctgacg   1440

gtctggctgt gaccccaacg ccggtgcccg tggtcgggag ccagatgacc agacaagccc   1500

ggcgcctcta cgtgggcaac atcccctttg gcatcactga ggaggccatg atggatttct   1560

tcaacgccca gatgcgcctg ggggggctga cccaggcccc tggcaaccca gtgttggctg   1620

tgcagattaa ccaggacaag aattttgcct ttttggagtt ccgctcagtg gacgagacta   1680

cccaggctat ggcctttgat ggcatcatct tccagggcca gtcactaaag atccgcaggc   1740

ctcacgacta ccagccgctt cctggcatgt cagagaaccc ctccgtctat gtgcctgggg   1800

ttgtgtccac tgtggtcccc gactctgccc acaagctgtt catcgggggc ttacccaact   1860

acctgaacga tgaccaggtc aaagagctgc tgacatcctt tgggcccctc aaggccttca   1920

acctggtcaa ggacagtgcc acggggctct ccaagggcta cgccttctgt gagtacgtgg   1980

acatcaacgt cacggatcag gccattgcgg ggctgaacgg catgcagctg ggggataaga   2040

agctgctggt ccagagggcg agtgtgggag ccaagaatgc cacgctgagc accatcaatc   2100

agacgcctgt gaccctgcaa gtgccgggct tgatgagctc ccaggtgcag atgggcggcc   2160

acccgactga ggtcctgtgc ctcatgaaca tggtgctgcc tgaggagctg ctggacgacg   2220

aggagtatga ggagatcgtg gaggatgtgc gggacgagtg cagcaagtac gggcttgtca   2280

agtccatcga gatcccccgg cctgtggacg gcgtcgaggt gcccggctgc ggaaagatct   2340

ttgtggagtt cacctctgtg tttgactgcc agaaagccat gcagggcctg acgggccgca   2400

agttcgccaa cagagtggtt gtcacaaaat actgtgaccc cgactcttat caccgccggg   2460

acttctggta gaggcggctg ggggagggtg ggggcagggc tggctggggg cttctcccca   2520

ctcccgcccc ccccttatcc ccctctgaag acgatgggca gaggagtgac agccgcagac   2580

acacgacagc cggcagcaac tggaatggca gcaattaagg gtggggggcg ggggttgggg   2640

ggttgggggg ttagggcagg gaggggactg gggaagtgcg cacacagccc acacagacaa   2700

cacgcaccca cacagacaca gagggaaggg gttgggatgg ggacagggtg cacagcaggg   2760

cggggtagga ccccagcccc tcccaaaaca gcctctcctt ctcccataga cccctttctt   2820

ctccccttcc ccacggtagg aacatagcgt gtttatattt tatggccaaa ctattttgaa   2880

ttttgttgtc cggccctcag tgccctgccc tctcccttac caggaccaca gctctgttcc   2940

ttcggcctct ggtcctctct ggtcccctcc tgggtttctt acgtagttga tttttcctct   3000

ttagtctccc ccgacctgcg cccagccccg tggcccctgc ccctctccta ctctctgtgg   3060

cagtttcata tttgctaaga cgaatttgct cattaaacat tttgttgtat tttactttaa   3120

aaaaaaaaaa aaaaaa                                                   3136


<210>  3771
<211>  471
<212>  PRT
<213>  Homosapiens

<400>  3771

Met Ser Asp Phe Asp Glu Phe Glu Arg Gln Leu Asn Glu Asn Lys Gln 
1               5                   10                  15      


Glu Arg Asp Lys Glu Asn Arg His Arg Lys Arg Ser His Ser Arg Ser 
            20                  25                  30          


Arg Ser Arg Asp Arg Lys Arg Arg Ser Arg Ser Arg Asp Arg Arg Asn 
        35                  40                  45              


Arg Asp Gln Arg Ser Ala Ser Arg Asp Arg Arg Arg Arg Ser Lys Pro 
    50                  55                  60                  


Leu Thr Arg Gly Ala Lys Glu Glu His Gly Gly Leu Ile Arg Ser Pro 
65                  70                  75                  80  


Arg His Glu Lys Lys Lys Lys Val Arg Lys Tyr Trp Asp Val Pro Pro 
                85                  90                  95      


Pro Gly Phe Glu His Ile Thr Pro Met Gln Tyr Lys Ala Met Gln Ala 
            100                 105                 110         


Ala Gly Gln Ile Pro Ala Thr Ala Leu Leu Pro Thr Met Thr Pro Asp 
        115                 120                 125             


Gly Leu Ala Val Thr Pro Thr Pro Val Pro Val Val Gly Ser Gln Met 
    130                 135                 140                 


Thr Arg Gln Ala Arg Arg Leu Tyr Val Gly Asn Ile Pro Phe Gly Ile 
145                 150                 155                 160 


Thr Glu Glu Ala Met Met Asp Phe Phe Asn Ala Gln Met Arg Leu Gly 
                165                 170                 175     


Gly Leu Thr Gln Ala Pro Gly Asn Pro Val Leu Ala Val Gln Ile Asn 
            180                 185                 190         


Gln Asp Lys Asn Phe Ala Phe Leu Glu Phe Arg Ser Val Asp Glu Thr 
        195                 200                 205             


Thr Gln Ala Met Ala Phe Asp Gly Ile Ile Phe Gln Gly Gln Ser Leu 
    210                 215                 220                 


Lys Ile Arg Arg Pro His Asp Tyr Gln Pro Leu Pro Gly Met Ser Glu 
225                 230                 235                 240 


Asn Pro Ser Val Tyr Val Pro Gly Val Val Ser Thr Val Val Pro Asp 
                245                 250                 255     


Ser Ala His Lys Leu Phe Ile Gly Gly Leu Pro Asn Tyr Leu Asn Asp 
            260                 265                 270         


Asp Gln Val Lys Glu Leu Leu Thr Ser Phe Gly Pro Leu Lys Ala Phe 
        275                 280                 285             


Asn Leu Val Lys Asp Ser Ala Thr Gly Leu Ser Lys Gly Tyr Ala Phe 
    290                 295                 300                 


Cys Glu Tyr Val Asp Ile Asn Val Thr Asp Gln Ala Ile Ala Gly Leu 
305                 310                 315                 320 


Asn Gly Met Gln Leu Gly Asp Lys Lys Leu Leu Val Gln Arg Ala Ser 
                325                 330                 335     


Val Gly Ala Lys Asn Ala Thr Leu Ser Thr Ile Asn Gln Thr Pro Val 
            340                 345                 350         


Thr Leu Gln Val Pro Gly Leu Met Ser Ser Gln Val Gln Met Gly Gly 
        355                 360                 365             


His Pro Thr Glu Val Leu Cys Leu Met Asn Met Val Leu Pro Glu Glu 
    370                 375                 380                 


Leu Leu Asp Asp Glu Glu Tyr Glu Glu Ile Val Glu Asp Val Arg Asp 
385                 390                 395                 400 


Glu Cys Ser Lys Tyr Gly Leu Val Lys Ser Ile Glu Ile Pro Arg Pro 
                405                 410                 415     


Val Asp Gly Val Glu Val Pro Gly Cys Gly Lys Ile Phe Val Glu Phe 
            420                 425                 430         


Thr Ser Val Phe Asp Cys Gln Lys Ala Met Gln Gly Leu Thr Gly Arg 
        435                 440                 445             


Lys Phe Ala Asn Arg Val Val Val Thr Lys Tyr Cys Asp Pro Asp Ser 
    450                 455                 460                 


Tyr His Arg Arg Asp Phe Trp 
465                 470     


<210>  3772
<211>  3148
<212>  DNA
<213>  Homosapiens

<400>  3772
ggagagcgcg ccacagaacg acttttacgc aggcgcagaa gcctgtttcc cctcacccgc     60

ggcttccacc ctgcgcaggc gcaaaaagcc gcgctggcaa cctccgcagc ggtcgcgcgc    120

acccttcacc cctcttgctg cttttgtctg gcacaacctt ctcaggccct ccgcgaggcc    180

ggcccttttt ttctttcact ttccccaccc ggagagccag gtgccgagaa ctaggacctc    240

gtccccttct ctatcccttc ccctgatcca tctcgtctct gttctccttc ccttttccgt    300

tcccgaagcc ggaaggagcc gaggtaccca cggaaaaagt cgaagctgtc cccggagagt    360

gaggccttca cgaagcggtg gcggaaggag ccgaagttct ctgatcggag gcgtgagcaa    420

gtggcatctc cggaaagagc cgaaacacgg actcgagctt aatcccagga ggggcccgag    480

ggcgagatcc ggaaatctcc ggaaagagcc gaaggccggg acggttagga ttgtcggaag    540

tggccgattg cttggacagg gccggcggag aagatcggag caagtccgtg gaagaagcca    600

aagactggga cggattgaat tgttggaaga acccgaactc gcagagggga ctgggcgcag    660

tggcacacga ggacacacgg aaacctccga acgttgagga gataatctcg gaaaagttac    720

ggaaacctgg gaagtcggcg aaaccctacg ttcgggtgtt ttcggaagca gccgaagcgg    780

ccgcctgctt cgccttcgtc cagtatccgg agatagccga ggcgcttcgg agccaggctc    840

ggggggaggg gcaagctcgc gggcgggcgg gcgggtgagg gggcggagcc cgggcggggc    900

ggggagggct gccggaggct tgattaggta ggaggtggcg aagcgccggc ggcggccgga    960

agtagccgaa gccagcggcg gaagtagccg aagcggctgg agcgggcggc aaggcgaggc   1020

gaaagctgca cagggcccta cgcggccgcc tcagcatgtc ggacttcgac gagttcgagc   1080

ggcagctcaa cgagaataaa caagagcggg acaaggagaa ccggcatcgg aagcgcagcc   1140

acagccgctc tcggagccgg gaccgcaaac gccggagccg gagccgcgac cggcgcaacc   1200

gggaccagcg gagcgcctcc cgggacaggc gacgacgcag caaacctttg accagaggcg   1260

ctaaagagga gcacggtgga ctgattcgtt ccccccgcca cgagaagaag aagaaggtcc   1320

gtaaatactg ggacgtgcca cccccaggct ttgagcacat caccccaatg cagtacaagg   1380

ccatgcaagc tgcgggtcag attccagcca ctgctcttct ccccaccatg acccctgacg   1440

gtctggctgt gaccccaacg ccggtgcccg tggtcgggag ccagatgacc agacaagccc   1500

ggcgcctcta cgtgggcaac atcccctttg gcatcactga ggaggccatg atggatttct   1560

tcaacgccca gatgcgcctg ggggggctga cccaggcccc tggcaaccca gtgttggctg   1620

tgcagattaa ccaggacaag aattttgcct ttttggagtt ccgctcagtg gacgagacta   1680

cccaggctat ggcctttgat ggcatcatct tccagggcca gtcactaaag atccgcaggc   1740

ctcacgacta ccagccgctt cctggcatgt cagagaaccc ctccgtctat gtgcctgggg   1800

ttgtgtccac tgtggtcccc gactctgccc acaagctgtt catcgggggc ttacccaact   1860

acctgaacga tgaccaggtc aaagagctgc tgacatcctt tgggcccctc aaggccttca   1920

acctggtcaa ggacagtgcc acggggctct ccaagggcta cgccttctgt gagtacgtgg   1980

acatcaacgt cacggatcag gccattgcgg ggctgaacgg catgcagctg ggggataaga   2040

agctgctggt ccagagggcg agtgtgggag ccaagaatgc cacgctggtg agccccccga   2100

gcaccatcaa tcagacgcct gtgaccctgc aagtgccggg cttgatgagc tcccaggtgc   2160

agatgggcgg ccacccgact gaggtcctgt gcctcatgaa catggtgctg cctgaggagc   2220

tgctggacga cgaggagtat gaggagatcg tggaggatgt gcgggacgag tgcagcaagt   2280

acgggcttgt caagtccatc gagatccccc ggcctgtgga cggcgtcgag gtgcccggct   2340

gcggaaagat ctttgtggag ttcacctctg tgtttgactg ccagaaagcc atgcagggcc   2400

tgacgggccg caagttcgcc aacagagtgg ttgtcacaaa atactgtgac cccgactctt   2460

atcaccgccg ggacttctgg tagaggcggc tgggggaggg tgggggcagg gctggctggg   2520

ggcttctccc cactcccgcc ccccccttat ccccctctga agacgatggg cagaggagtg   2580

acagccgcag acacacgaca gccggcagca actggaatgg cagcaattaa gggtgggggg   2640

cgggggttgg ggggttgggg ggttagggca gggaggggac tggggaagtg cgcacacagc   2700

ccacacagac aacacgcacc cacacagaca cagagggaag gggttgggat ggggacaggg   2760

tgcacagcag ggcggggtag gaccccagcc cctcccaaaa cagcctctcc ttctcccata   2820

gacccctttc ttctcccctt ccccacggta ggaacatagc gtgtttatat tttatggcca   2880

aactattttg aattttgttg tccggccctc agtgccctgc cctctccctt accaggacca   2940

cagctctgtt ccttcggcct ctggtcctct ctggtcccct cctgggtttc ttacgtagtt   3000

gatttttcct ctttagtctc ccccgacctg cgcccagccc cgtggcccct gcccctctcc   3060

tactctctgt ggcagtttca tatttgctaa gacgaatttg ctcattaaac attttgttgt   3120

attttacttt aaaaaaaaaa aaaaaaaa                                      3148


<210>  3773
<211>  475
<212>  PRT
<213>  Homosapiens

<400>  3773

Met Ser Asp Phe Asp Glu Phe Glu Arg Gln Leu Asn Glu Asn Lys Gln 
1               5                   10                  15      


Glu Arg Asp Lys Glu Asn Arg His Arg Lys Arg Ser His Ser Arg Ser 
            20                  25                  30          


Arg Ser Arg Asp Arg Lys Arg Arg Ser Arg Ser Arg Asp Arg Arg Asn 
        35                  40                  45              


Arg Asp Gln Arg Ser Ala Ser Arg Asp Arg Arg Arg Arg Ser Lys Pro 
    50                  55                  60                  


Leu Thr Arg Gly Ala Lys Glu Glu His Gly Gly Leu Ile Arg Ser Pro 
65                  70                  75                  80  


Arg His Glu Lys Lys Lys Lys Val Arg Lys Tyr Trp Asp Val Pro Pro 
                85                  90                  95      


Pro Gly Phe Glu His Ile Thr Pro Met Gln Tyr Lys Ala Met Gln Ala 
            100                 105                 110         


Ala Gly Gln Ile Pro Ala Thr Ala Leu Leu Pro Thr Met Thr Pro Asp 
        115                 120                 125             


Gly Leu Ala Val Thr Pro Thr Pro Val Pro Val Val Gly Ser Gln Met 
    130                 135                 140                 


Thr Arg Gln Ala Arg Arg Leu Tyr Val Gly Asn Ile Pro Phe Gly Ile 
145                 150                 155                 160 


Thr Glu Glu Ala Met Met Asp Phe Phe Asn Ala Gln Met Arg Leu Gly 
                165                 170                 175     


Gly Leu Thr Gln Ala Pro Gly Asn Pro Val Leu Ala Val Gln Ile Asn 
            180                 185                 190         


Gln Asp Lys Asn Phe Ala Phe Leu Glu Phe Arg Ser Val Asp Glu Thr 
        195                 200                 205             


Thr Gln Ala Met Ala Phe Asp Gly Ile Ile Phe Gln Gly Gln Ser Leu 
    210                 215                 220                 


Lys Ile Arg Arg Pro His Asp Tyr Gln Pro Leu Pro Gly Met Ser Glu 
225                 230                 235                 240 


Asn Pro Ser Val Tyr Val Pro Gly Val Val Ser Thr Val Val Pro Asp 
                245                 250                 255     


Ser Ala His Lys Leu Phe Ile Gly Gly Leu Pro Asn Tyr Leu Asn Asp 
            260                 265                 270         


Asp Gln Val Lys Glu Leu Leu Thr Ser Phe Gly Pro Leu Lys Ala Phe 
        275                 280                 285             


Asn Leu Val Lys Asp Ser Ala Thr Gly Leu Ser Lys Gly Tyr Ala Phe 
    290                 295                 300                 


Cys Glu Tyr Val Asp Ile Asn Val Thr Asp Gln Ala Ile Ala Gly Leu 
305                 310                 315                 320 


Asn Gly Met Gln Leu Gly Asp Lys Lys Leu Leu Val Gln Arg Ala Ser 
                325                 330                 335     


Val Gly Ala Lys Asn Ala Thr Leu Val Ser Pro Pro Ser Thr Ile Asn 
            340                 345                 350         


Gln Thr Pro Val Thr Leu Gln Val Pro Gly Leu Met Ser Ser Gln Val 
        355                 360                 365             


Gln Met Gly Gly His Pro Thr Glu Val Leu Cys Leu Met Asn Met Val 
    370                 375                 380                 


Leu Pro Glu Glu Leu Leu Asp Asp Glu Glu Tyr Glu Glu Ile Val Glu 
385                 390                 395                 400 


Asp Val Arg Asp Glu Cys Ser Lys Tyr Gly Leu Val Lys Ser Ile Glu 
                405                 410                 415     


Ile Pro Arg Pro Val Asp Gly Val Glu Val Pro Gly Cys Gly Lys Ile 
            420                 425                 430         


Phe Val Glu Phe Thr Ser Val Phe Asp Cys Gln Lys Ala Met Gln Gly 
        435                 440                 445             


Leu Thr Gly Arg Lys Phe Ala Asn Arg Val Val Val Thr Lys Tyr Cys 
    450                 455                 460                 


Asp Pro Asp Ser Tyr His Arg Arg Asp Phe Trp 
465                 470                 475 


<210>  3774
<211>  2430
<212>  DNA
<213>  Homosapiens

<400>  3774
ctgttgcttc ccgtctcctc ggcggctccc ctcccccgcc cggctctccg cgccccttct     60

gggcggcggg gcggcggagc cgtcggcgtg cggccctcct tgcgttcgtg cgtgcgcccg    120

tggcccggcg cacgtcccgc gacaccgagg ccgagcgggg cagggggctg accgccatga    180

ccccccagag cccggcgtga gggggccgag atgcggtgac ctgccagcac ctgccgcagc    240

cttcgtccgg gagtcgcccc atctctccac gcatcggggc cctgtgcccc ttgctgctgc    300

agccgggcac catgtcgacc tcgtccttga ggcgccagat gaagaacatc gtccacaact    360

actcagaggc ggagatcaag gttcgagagg ccacgagcaa tgacccctgg ggcccatcca    420

gctccctcat gtcagagatt gccgacctca cctacaacgt tgtcgccttc tcggagatca    480

tgagcatgat ctggaagcgg ctcaatgacc atggcaagaa ctggcgtcac gtttacaagg    540

ccatgacgct gatggagtac ctcatcaaga ccggctcgga gcgcgtgtcg cagcagtgca    600

aggagaacat gtacgccgtg cagacgctga aggacttcca gtacgtggac cgcgacggca    660

aggaccaggg cgtgaacgtg cgtgagaaag ctaagcagct ggtggccctg ctgcgcgacg    720

aggaccggct gcgggaagag cgggcgcacg cgctcaagac caaggaaaag ctggcacaga    780

ccgccacggc ctcatcagca gctgtgggct caggcccccc tcccgaggcg gagcaggcgt    840

ggccgcagag cagcggggag gaggagctgc agctccagct ggccctggcc atgagcaagg    900

aggaggccga ccaggaggag cggatccgtc gcggggatga cctgcggctg cagatggcaa    960

tcgaggagag caagagggag actgggggca aggaggagtc gtccctcatg gaccttgctg   1020

acgtcttcac ggccccagct cctgccccga ccacagaccc ctgggggggc ccagcaccca   1080

tggctgctgc cgtccccacg gctgccccca cctcggaccc ctggggcggc ccccctgtcc   1140

ctccagctgc tgatccctgg ggaggtccag cccccacgcc ggcctctggg gacccctgga   1200

ggcctgctgc ccctgcagga ccctcagttg acccttgggg tgggacccca gcccctgcag   1260

ctggggaggg gcccacgcct gatccatggg gaagttccga tggtggggtc ccggtcagtg   1320

ggccctcagc ctccgatccc tggacaccgg ccccggcctt ctcagatccc tggggagggt   1380

cacctgccaa gcccagcacc aatggcacaa cagccggggg attcgacacg gagcccgacg   1440

agttctctga ctttgaccga ctccgcacgg cactgccgac ctccgggagc agcgcaggag   1500

agctggagct gctggcagga gaggtgccgg cccgaagccc tggggcgttt gacatgagtg   1560

gggtcagggg atctctggct gaggctgtgg gcagcccccc acctgcagcc acaccaactc   1620

ccacgccccc cacccggaag acgccggagt cattcctggg gcccaatgca gccctcgtcg   1680

acctggactc gctggtgagc cggccgggcc ccacgccgcc tggagccaag gcctccaacc   1740

ccttcctgcc aggcggaggc ccagccactg gcccttccgt caccaacccc ttccagcccg   1800

cgcctcccgc gacgctcacc ctgaaccagc tccgtctcag tcctgtgcct cccgtccctg   1860

gagcgccacc cacgtacatc tctccccttg gcgggggccc tggcctgccc cccatgatgc   1920

ccccgggccc cccggccccc aacactaatc ccttcctcct ataatccagg gcggaagggg   1980

gcctggctcc atccggctgc cccattccgg ctccctggga gatcagtgtt gtgagtgcat   2040

gtgaaatggg ggatccccac ccccagtgcc cttccccttc ctggggccca ctcacactac   2100

accctcttcc tttcccaccc cacctccccg gagagaaact ggacatgggg cctggggagg   2160

ggagctggcc agaggaggac ccctttcccg tggcattaga agggggaggg gtggctgggg   2220

cccccaccca ttccccctcc ctccaaactc ccaaccccca gtcagtgttt gagcctcctc   2280

gttcccctca cgcacccgct cacgcaccct cggtgaatcc ttggtgatga ttttggcaac   2340

tttgggaata aatggcaatt cccacgggct tggcaaaaaa aaaaaaaaaa aaaaaaaaaa   2400

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                    2430


<210>  3775
<211>  550
<212>  PRT
<213>  Homosapiens

<400>  3775

Met Ser Thr Ser Ser Leu Arg Arg Gln Met Lys Asn Ile Val His Asn 
1               5                   10                  15      


Tyr Ser Glu Ala Glu Ile Lys Val Arg Glu Ala Thr Ser Asn Asp Pro 
            20                  25                  30          


Trp Gly Pro Ser Ser Ser Leu Met Ser Glu Ile Ala Asp Leu Thr Tyr 
        35                  40                  45              


Asn Val Val Ala Phe Ser Glu Ile Met Ser Met Ile Trp Lys Arg Leu 
    50                  55                  60                  


Asn Asp His Gly Lys Asn Trp Arg His Val Tyr Lys Ala Met Thr Leu 
65                  70                  75                  80  


Met Glu Tyr Leu Ile Lys Thr Gly Ser Glu Arg Val Ser Gln Gln Cys 
                85                  90                  95      


Lys Glu Asn Met Tyr Ala Val Gln Thr Leu Lys Asp Phe Gln Tyr Val 
            100                 105                 110         


Asp Arg Asp Gly Lys Asp Gln Gly Val Asn Val Arg Glu Lys Ala Lys 
        115                 120                 125             


Gln Leu Val Ala Leu Leu Arg Asp Glu Asp Arg Leu Arg Glu Glu Arg 
    130                 135                 140                 


Ala His Ala Leu Lys Thr Lys Glu Lys Leu Ala Gln Thr Ala Thr Ala 
145                 150                 155                 160 


Ser Ser Ala Ala Val Gly Ser Gly Pro Pro Pro Glu Ala Glu Gln Ala 
                165                 170                 175     


Trp Pro Gln Ser Ser Gly Glu Glu Glu Leu Gln Leu Gln Leu Ala Leu 
            180                 185                 190         


Ala Met Ser Lys Glu Glu Ala Asp Gln Glu Glu Arg Ile Arg Arg Gly 
        195                 200                 205             


Asp Asp Leu Arg Leu Gln Met Ala Ile Glu Glu Ser Lys Arg Glu Thr 
    210                 215                 220                 


Gly Gly Lys Glu Glu Ser Ser Leu Met Asp Leu Ala Asp Val Phe Thr 
225                 230                 235                 240 


Ala Pro Ala Pro Ala Pro Thr Thr Asp Pro Trp Gly Gly Pro Ala Pro 
                245                 250                 255     


Met Ala Ala Ala Val Pro Thr Ala Ala Pro Thr Ser Asp Pro Trp Gly 
            260                 265                 270         


Gly Pro Pro Val Pro Pro Ala Ala Asp Pro Trp Gly Gly Pro Ala Pro 
        275                 280                 285             


Thr Pro Ala Ser Gly Asp Pro Trp Arg Pro Ala Ala Pro Ala Gly Pro 
    290                 295                 300                 


Ser Val Asp Pro Trp Gly Gly Thr Pro Ala Pro Ala Ala Gly Glu Gly 
305                 310                 315                 320 


Pro Thr Pro Asp Pro Trp Gly Ser Ser Asp Gly Gly Val Pro Val Ser 
                325                 330                 335     


Gly Pro Ser Ala Ser Asp Pro Trp Thr Pro Ala Pro Ala Phe Ser Asp 
            340                 345                 350         


Pro Trp Gly Gly Ser Pro Ala Lys Pro Ser Thr Asn Gly Thr Thr Ala 
        355                 360                 365             


Gly Gly Phe Asp Thr Glu Pro Asp Glu Phe Ser Asp Phe Asp Arg Leu 
    370                 375                 380                 


Arg Thr Ala Leu Pro Thr Ser Gly Ser Ser Ala Gly Glu Leu Glu Leu 
385                 390                 395                 400 


Leu Ala Gly Glu Val Pro Ala Arg Ser Pro Gly Ala Phe Asp Met Ser 
                405                 410                 415     


Gly Val Arg Gly Ser Leu Ala Glu Ala Val Gly Ser Pro Pro Pro Ala 
            420                 425                 430         


Ala Thr Pro Thr Pro Thr Pro Pro Thr Arg Lys Thr Pro Glu Ser Phe 
        435                 440                 445             


Leu Gly Pro Asn Ala Ala Leu Val Asp Leu Asp Ser Leu Val Ser Arg 
    450                 455                 460                 


Pro Gly Pro Thr Pro Pro Gly Ala Lys Ala Ser Asn Pro Phe Leu Pro 
465                 470                 475                 480 


Gly Gly Gly Pro Ala Thr Gly Pro Ser Val Thr Asn Pro Phe Gln Pro 
                485                 490                 495     


Ala Pro Pro Ala Thr Leu Thr Leu Asn Gln Leu Arg Leu Ser Pro Val 
            500                 505                 510         


Pro Pro Val Pro Gly Ala Pro Pro Thr Tyr Ile Ser Pro Leu Gly Gly 
        515                 520                 525             


Gly Pro Gly Leu Pro Pro Met Met Pro Pro Gly Pro Pro Ala Pro Asn 
    530                 535                 540                 


Thr Asn Pro Phe Leu Leu 
545                 550 


<210>  3776
<211>  3484
<212>  DNA
<213>  Homosapiens

<400>  3776
acacctcagt tcacaatcct ggggcgatat ggcagaatct tttttttcgg attttggctt     60

gttgtggtat ctgaaggagc tcagaaagga agagttttgg aaatttaagg agctcctcaa    120

acaacctttg gagaaatttg aactcaagcc aatcccctgg gctgagctga agaaggcctc    180

caaagaagat gtagcaaagc tgctggacaa acattaccca ggaaagcagg catgggaggt    240

aacactgaac ctgtttctac agatcaatag gaaagatctc tggacaaagg ctcaggaaga    300

gatgagaaat aagctaaacc catacagaaa gcatatgaag gaaacatttc aactcatatg    360

ggagaaggaa acctgtcttc acgtccctga gcatttctac aaagaaacca tgaaaaatga    420

gtataaagaa ttgaatgacg catatactgc tgcggctaga cgacacactg tggtcctgga    480

aggtcctgat ggaattggaa aaacaaccct tttaagaaaa gtgatgttgg actgggcaga    540

gggaaactta tggaaggaca ggttcacatt tgtgtttttc ctcaatgtct gtgaaatgaa    600

cggtatcgca gagaccagct tactggagct cctctctagg gactggccgg agtcttcaga    660

gaagatcgaa gacatttttt cccagccaga gagaattctg ttcatcatgg atggctttga    720

gcaactgaag tttaacttac aacttaaggc tgacttgagc gatgattgga ggcagcggca    780

gccaatgcca attatcctga gcagtttgtt gcaaaaaaag atgcttccag aatcctctct    840

ccttattgca ttaggaaaac tggctatgca aaaacactat tttatgttgc ggcatccaaa    900

actcataaag ctcttaggat tcagtgaatc tgaaaagaag tcgtatttct cctacttctt    960

tggtgagaag agcaaagccc tgaaagtctt caattttgtg agagataatg ggccgctgtt   1020

tatcttgtgc cataatccct ttacgtgctg gttggtctgt acttgtgtga aacagaggct   1080

agagagggga gaagaccttg aaataaactc ccaaaacacc acctatttat atgcatcctt   1140

tttaacaact gtattcaaag caggaagtca gagttttcca cctaaggtga acagagcccg   1200

actaaaaagc ctgtgtgctt tggctgcaga gggaatttgg acatatacat ttgtattttc   1260

ccatggggat ctccggagga atgggttatc tgagtctgag ggcgtgatgt gggtgggtat   1320

gagactcctc caaaggagag gggactgttt tgccttcatg catctgtgta tccaagagtt   1380

ttgtgccgcc atgttttatt tgctcaaacg acccaaagac gatcctaacc cggccattgg   1440

aagcataacc cagcttgtaa gagcaagtgt ggttcagcct caaaccctct tgacccaggt   1500

ggggatattc atgtttggaa tttcaacaga agaaatcgtc agcatgctgg agacctcctt   1560

tggttttcca ctgtcaaaag acctaaagca ggaaataacc caatgccttg aaagtttaag   1620

tcaatgtgaa gctgataggg aagccatagc tttccaggaa ctattcattg gtttgtttga   1680

aactcaggaa aaagaatttg taaccaaagt gatgaatttc tttgaagaag ttttcattta   1740

tattggtaac atagaacatt tggtaatagc ttcattctgc ctgaagcatt gtcaacattt   1800

aacgacactt cgcatgtgtg tggagaatat ctttccagat gactcaggat gcatctcaga   1860

ttacaatgag aagctcgtct actggcggga gctttgctca atgttcatta ccaacaagaa   1920

cttccagatt ttagacatgg aaaataccag ccttgatgat ccctccctgg cgattctttg   1980

caaagcgctg gctcagcctg tttgtaaact ccgaaaactc atatttactt ctgtgtactt   2040

tggacatgat tcagaattat ttaaggcagt tcttcacaac cctcatctga aacttctgag   2100

cctgtacggc actagcctct cccagtctga catcagacac ctgtgtgaga cgctgaaaca   2160

tccaatgtgc aagatagaag agctgatact gggaaagtgt gacatctcca gtgaagtttg   2220

tgaagacatc gcctccgtcc tggcctgcaa cagcaagctg aaacacctct ccttggtaga   2280

aaatcccttg agggacgaag gaatgacgtt gctgtgtgaa gccctgaagc actcacactg   2340

tgccctggag aggctgatgt tgatgtactg ctgtctcacc tctgtctcct gtgactccat   2400

ttccgaagtc ctcttgtgca gtaagtccct gtccctcctc gatctgggct caaatgccct   2460

ggaagataat ggagtggcat ctctgtgtgc agcgctgaag cacccaggct gcagcatacg   2520

ggagctgtgg ttgatgggct gtttccttac ttccgattcc tgtaaggaca ttgctgctgt   2580

tcttatttgc aatgggaaac tgaagaccct gaaacttggg cataatgaaa taggagacac   2640

tggtgtcaga cagttatgtg cagctttgca gcatcctcac tgtaaattag agtgtctcgg   2700

gctgcaaacg tgtccgatca cccgtgcctg ctgcgacgac atcgccgcag cactcatcgc   2760

ctgcaaaaca ctgaggagcc tgaacctcga ctggattgcc ttggatgctg atgcagtggt   2820

ggtgctgtgt gaggcattga gccacccgga ctgtgccctg cagatgctgg ggctgcacaa   2880

atctggcttt gatgaagaaa ctcagaagat cctgatgtct gtggaagaaa aaattcccca   2940

tctgaccatt tcacatggac cttggattga cgaggaatac aagatcaggg gtgtgctcct   3000

ctgatgggga acaccctgaa gtagtcgtct cacaaaggct ttccttggcc acagtgggac   3060

cttcacctgg cacctctatc ctgtaattgc acatcatggc agcagggctg tgatttcaga   3120

ggtactccct aagtgttcta gcaatatgat tatggagtgt gattcagtgt acatgctgat   3180

tgtctttgcc tcggtcctat atccccttgt ctttagaaat cccatcctgc cttgtgatat   3240

ttagaagcac aagtacgtta aacaagtgct aaacgctctg gaaagcatgg ctttattttc   3300

ttaatggatg tcttggtgtg taggagcatg catttgtagg caccacaatc cggatacttc   3360

tgacacagaa gtgatgctag aatgtgtcta tagattgtat tgctagcatc cagactttct   3420

agtttgtcca gatttcgatt tgatcaattt tcttgtccaa taaaaaagca tttccaaatc   3480

tcta                                                                3484


<210>  3777
<211>  991
<212>  PRT
<213>  Homosapiens

<400>  3777

Met Ala Glu Ser Phe Phe Ser Asp Phe Gly Leu Leu Trp Tyr Leu Lys 
1               5                   10                  15      


Glu Leu Arg Lys Glu Glu Phe Trp Lys Phe Lys Glu Leu Leu Lys Gln 
            20                  25                  30          


Pro Leu Glu Lys Phe Glu Leu Lys Pro Ile Pro Trp Ala Glu Leu Lys 
        35                  40                  45              


Lys Ala Ser Lys Glu Asp Val Ala Lys Leu Leu Asp Lys His Tyr Pro 
    50                  55                  60                  


Gly Lys Gln Ala Trp Glu Val Thr Leu Asn Leu Phe Leu Gln Ile Asn 
65                  70                  75                  80  


Arg Lys Asp Leu Trp Thr Lys Ala Gln Glu Glu Met Arg Asn Lys Leu 
                85                  90                  95      


Asn Pro Tyr Arg Lys His Met Lys Glu Thr Phe Gln Leu Ile Trp Glu 
            100                 105                 110         


Lys Glu Thr Cys Leu His Val Pro Glu His Phe Tyr Lys Glu Thr Met 
        115                 120                 125             


Lys Asn Glu Tyr Lys Glu Leu Asn Asp Ala Tyr Thr Ala Ala Ala Arg 
    130                 135                 140                 


Arg His Thr Val Val Leu Glu Gly Pro Asp Gly Ile Gly Lys Thr Thr 
145                 150                 155                 160 


Leu Leu Arg Lys Val Met Leu Asp Trp Ala Glu Gly Asn Leu Trp Lys 
                165                 170                 175     


Asp Arg Phe Thr Phe Val Phe Phe Leu Asn Val Cys Glu Met Asn Gly 
            180                 185                 190         


Ile Ala Glu Thr Ser Leu Leu Glu Leu Leu Ser Arg Asp Trp Pro Glu 
        195                 200                 205             


Ser Ser Glu Lys Ile Glu Asp Ile Phe Ser Gln Pro Glu Arg Ile Leu 
    210                 215                 220                 


Phe Ile Met Asp Gly Phe Glu Gln Leu Lys Phe Asn Leu Gln Leu Lys 
225                 230                 235                 240 


Ala Asp Leu Ser Asp Asp Trp Arg Gln Arg Gln Pro Met Pro Ile Ile 
                245                 250                 255     


Leu Ser Ser Leu Leu Gln Lys Lys Met Leu Pro Glu Ser Ser Leu Leu 
            260                 265                 270         


Ile Ala Leu Gly Lys Leu Ala Met Gln Lys His Tyr Phe Met Leu Arg 
        275                 280                 285             


His Pro Lys Leu Ile Lys Leu Leu Gly Phe Ser Glu Ser Glu Lys Lys 
    290                 295                 300                 


Ser Tyr Phe Ser Tyr Phe Phe Gly Glu Lys Ser Lys Ala Leu Lys Val 
305                 310                 315                 320 


Phe Asn Phe Val Arg Asp Asn Gly Pro Leu Phe Ile Leu Cys His Asn 
                325                 330                 335     


Pro Phe Thr Cys Trp Leu Val Cys Thr Cys Val Lys Gln Arg Leu Glu 
            340                 345                 350         


Arg Gly Glu Asp Leu Glu Ile Asn Ser Gln Asn Thr Thr Tyr Leu Tyr 
        355                 360                 365             


Ala Ser Phe Leu Thr Thr Val Phe Lys Ala Gly Ser Gln Ser Phe Pro 
    370                 375                 380                 


Pro Lys Val Asn Arg Ala Arg Leu Lys Ser Leu Cys Ala Leu Ala Ala 
385                 390                 395                 400 


Glu Gly Ile Trp Thr Tyr Thr Phe Val Phe Ser His Gly Asp Leu Arg 
                405                 410                 415     


Arg Asn Gly Leu Ser Glu Ser Glu Gly Val Met Trp Val Gly Met Arg 
            420                 425                 430         


Leu Leu Gln Arg Arg Gly Asp Cys Phe Ala Phe Met His Leu Cys Ile 
        435                 440                 445             


Gln Glu Phe Cys Ala Ala Met Phe Tyr Leu Leu Lys Arg Pro Lys Asp 
    450                 455                 460                 


Asp Pro Asn Pro Ala Ile Gly Ser Ile Thr Gln Leu Val Arg Ala Ser 
465                 470                 475                 480 


Val Val Gln Pro Gln Thr Leu Leu Thr Gln Val Gly Ile Phe Met Phe 
                485                 490                 495     


Gly Ile Ser Thr Glu Glu Ile Val Ser Met Leu Glu Thr Ser Phe Gly 
            500                 505                 510         


Phe Pro Leu Ser Lys Asp Leu Lys Gln Glu Ile Thr Gln Cys Leu Glu 
        515                 520                 525             


Ser Leu Ser Gln Cys Glu Ala Asp Arg Glu Ala Ile Ala Phe Gln Glu 
    530                 535                 540                 


Leu Phe Ile Gly Leu Phe Glu Thr Gln Glu Lys Glu Phe Val Thr Lys 
545                 550                 555                 560 


Val Met Asn Phe Phe Glu Glu Val Phe Ile Tyr Ile Gly Asn Ile Glu 
                565                 570                 575     


His Leu Val Ile Ala Ser Phe Cys Leu Lys His Cys Gln His Leu Thr 
            580                 585                 590         


Thr Leu Arg Met Cys Val Glu Asn Ile Phe Pro Asp Asp Ser Gly Cys 
        595                 600                 605             


Ile Ser Asp Tyr Asn Glu Lys Leu Val Tyr Trp Arg Glu Leu Cys Ser 
    610                 615                 620                 


Met Phe Ile Thr Asn Lys Asn Phe Gln Ile Leu Asp Met Glu Asn Thr 
625                 630                 635                 640 


Ser Leu Asp Asp Pro Ser Leu Ala Ile Leu Cys Lys Ala Leu Ala Gln 
                645                 650                 655     


Pro Val Cys Lys Leu Arg Lys Leu Ile Phe Thr Ser Val Tyr Phe Gly 
            660                 665                 670         


His Asp Ser Glu Leu Phe Lys Ala Val Leu His Asn Pro His Leu Lys 
        675                 680                 685             


Leu Leu Ser Leu Tyr Gly Thr Ser Leu Ser Gln Ser Asp Ile Arg His 
    690                 695                 700                 


Leu Cys Glu Thr Leu Lys His Pro Met Cys Lys Ile Glu Glu Leu Ile 
705                 710                 715                 720 


Leu Gly Lys Cys Asp Ile Ser Ser Glu Val Cys Glu Asp Ile Ala Ser 
                725                 730                 735     


Val Leu Ala Cys Asn Ser Lys Leu Lys His Leu Ser Leu Val Glu Asn 
            740                 745                 750         


Pro Leu Arg Asp Glu Gly Met Thr Leu Leu Cys Glu Ala Leu Lys His 
        755                 760                 765             


Ser His Cys Ala Leu Glu Arg Leu Met Leu Met Tyr Cys Cys Leu Thr 
    770                 775                 780                 


Ser Val Ser Cys Asp Ser Ile Ser Glu Val Leu Leu Cys Ser Lys Ser 
785                 790                 795                 800 


Leu Ser Leu Leu Asp Leu Gly Ser Asn Ala Leu Glu Asp Asn Gly Val 
                805                 810                 815     


Ala Ser Leu Cys Ala Ala Leu Lys His Pro Gly Cys Ser Ile Arg Glu 
            820                 825                 830         


Leu Trp Leu Met Gly Cys Phe Leu Thr Ser Asp Ser Cys Lys Asp Ile 
        835                 840                 845             


Ala Ala Val Leu Ile Cys Asn Gly Lys Leu Lys Thr Leu Lys Leu Gly 
    850                 855                 860                 


His Asn Glu Ile Gly Asp Thr Gly Val Arg Gln Leu Cys Ala Ala Leu 
865                 870                 875                 880 


Gln His Pro His Cys Lys Leu Glu Cys Leu Gly Leu Gln Thr Cys Pro 
                885                 890                 895     


Ile Thr Arg Ala Cys Cys Asp Asp Ile Ala Ala Ala Leu Ile Ala Cys 
            900                 905                 910         


Lys Thr Leu Arg Ser Leu Asn Leu Asp Trp Ile Ala Leu Asp Ala Asp 
        915                 920                 925             


Ala Val Val Val Leu Cys Glu Ala Leu Ser His Pro Asp Cys Ala Leu 
    930                 935                 940                 


Gln Met Leu Gly Leu His Lys Ser Gly Phe Asp Glu Glu Thr Gln Lys 
945                 950                 955                 960 


Ile Leu Met Ser Val Glu Glu Lys Ile Pro His Leu Thr Ile Ser His 
                965                 970                 975     


Gly Pro Trp Ile Asp Glu Glu Tyr Lys Ile Arg Gly Val Leu Leu 
            980                 985                 990     


<210>  3778
<211>  1257
<212>  DNA
<213>  Homosapiens

<400>  3778
atgctgttgg tggccaccat attggacagc ccgggtctag acccttttta ccacttcaac     60

tctatgtcga ataatgaacg atattcttca ttccagctag catgtgaaat tcagaagtca    120

gcagccatga ctcttcacgt ctgtacccgt attgcctggt acaagggata tcacatagta    180

ggtaaaaacc tgtccaatag taacaatctc aatgatggca gaatgaaatc agaatctgat    240

tggattaaaa aggagggaaa gggtgtggct aaggtgggtg gagacaccct ctggtataaa    300

agcccctggc aggcagctct cactccagat ctgagctgtc cgcagaagca gctggaggcc    360

aggggagaaa ctccagaagg agagacattt gccatggctg agcacttcaa acagatcatt    420

agatgtcctg tctgtctaaa agatcttgaa gaagccgtgc aactgaaatg tggatatgcc    480

tgctgcctcc agtgcctcaa ttcactccag aaggagcccg atggggaagg tttactgtgc    540

cgtttctgct ctgtggtctc tcagaaggat gacatcaagc ccaagtacaa gctgagggcg    600

ctggtttcca tcatcaagga actagagccc aagctgaaat ctgttctaac aatgaaccca    660

aggatgagga agtttcaagt ggatatgacg ttcgatgtgg acacagccaa caactatctc    720

atcatttctg aagacctgag gagtttccga agtggggatt tgagccagaa taggaaggag    780

caagctgaga ggttcgacac tgccctgtgc gtcctgggca cccctcgctt cacttccggc    840

cgccattact gggaggtgga cgtgggcacc agccaagtgt gggatgtggg cgtgtgcaag    900

gaatctgtga accgacaggg gaagattgtg ctttcttcag aacacggctt cttgactgtg    960

ggttgcagag aaggaaaggt ctttgctgcc agcactgtgc ctatgactcc tctctgggtg   1020

agtccccagt tgcacagagt ggggattttc ctggatgtag gtatgaggtc cattgccttt   1080

tacaatgtta gtgatgggtg ccatatctac acattcatcg agattcctgt ttgcgagccc   1140

tggcgtccat tttttgctca taaacgtgga agtcaagatg atcagagcat cctgagtatc   1200

tgttctgtga tcaatccatc cgctgccagt gccccagttt cttctgaggg aaagtaa      1257


<210>  3779
<211>  418
<212>  PRT
<213>  Homosapiens

<400>  3779

Met Leu Leu Val Ala Thr Ile Leu Asp Ser Pro Gly Leu Asp Pro Phe 
1               5                   10                  15      


Tyr His Phe Asn Ser Met Ser Asn Asn Glu Arg Tyr Ser Ser Phe Gln 
            20                  25                  30          


Leu Ala Cys Glu Ile Gln Lys Ser Ala Ala Met Thr Leu His Val Cys 
        35                  40                  45              


Thr Arg Ile Ala Trp Tyr Lys Gly Tyr His Ile Val Gly Lys Asn Leu 
    50                  55                  60                  


Ser Asn Ser Asn Asn Leu Asn Asp Gly Arg Met Lys Ser Glu Ser Asp 
65                  70                  75                  80  


Trp Ile Lys Lys Glu Gly Lys Gly Val Ala Lys Val Gly Gly Asp Thr 
                85                  90                  95      


Leu Trp Tyr Lys Ser Pro Trp Gln Ala Ala Leu Thr Pro Asp Leu Ser 
            100                 105                 110         


Cys Pro Gln Lys Gln Leu Glu Ala Arg Gly Glu Thr Pro Glu Gly Glu 
        115                 120                 125             


Thr Phe Ala Met Ala Glu His Phe Lys Gln Ile Ile Arg Cys Pro Val 
    130                 135                 140                 


Cys Leu Lys Asp Leu Glu Glu Ala Val Gln Leu Lys Cys Gly Tyr Ala 
145                 150                 155                 160 


Cys Cys Leu Gln Cys Leu Asn Ser Leu Gln Lys Glu Pro Asp Gly Glu 
                165                 170                 175     


Gly Leu Leu Cys Arg Phe Cys Ser Val Val Ser Gln Lys Asp Asp Ile 
            180                 185                 190         


Lys Pro Lys Tyr Lys Leu Arg Ala Leu Val Ser Ile Ile Lys Glu Leu 
        195                 200                 205             


Glu Pro Lys Leu Lys Ser Val Leu Thr Met Asn Pro Arg Met Arg Lys 
    210                 215                 220                 


Phe Gln Val Asp Met Thr Phe Asp Val Asp Thr Ala Asn Asn Tyr Leu 
225                 230                 235                 240 


Ile Ile Ser Glu Asp Leu Arg Ser Phe Arg Ser Gly Asp Leu Ser Gln 
                245                 250                 255     


Asn Arg Lys Glu Gln Ala Glu Arg Phe Asp Thr Ala Leu Cys Val Leu 
            260                 265                 270         


Gly Thr Pro Arg Phe Thr Ser Gly Arg His Tyr Trp Glu Val Asp Val 
        275                 280                 285             


Gly Thr Ser Gln Val Trp Asp Val Gly Val Cys Lys Glu Ser Val Asn 
    290                 295                 300                 


Arg Gln Gly Lys Ile Val Leu Ser Ser Glu His Gly Phe Leu Thr Val 
305                 310                 315                 320 


Gly Cys Arg Glu Gly Lys Val Phe Ala Ala Ser Thr Val Pro Met Thr 
                325                 330                 335     


Pro Leu Trp Val Ser Pro Gln Leu His Arg Val Gly Ile Phe Leu Asp 
            340                 345                 350         


Val Gly Met Arg Ser Ile Ala Phe Tyr Asn Val Ser Asp Gly Cys His 
        355                 360                 365             


Ile Tyr Thr Phe Ile Glu Ile Pro Val Cys Glu Pro Trp Arg Pro Phe 
    370                 375                 380                 


Phe Ala His Lys Arg Gly Ser Gln Asp Asp Gln Ser Ile Leu Ser Ile 
385                 390                 395                 400 


Cys Ser Val Ile Asn Pro Ser Ala Ala Ser Ala Pro Val Ser Ser Glu 
                405                 410                 415     


Gly Lys 
        


<210>  3780
<211>  3439
<212>  DNA
<213>  Homosapiens

<400>  3780
ccacgcgtcc ggccaaggag acctggtggc agggttgatc tcatatttct tgtgcctcaa     60

aatcccttct ctgaagtctg ccttccctgg agaagcaaga tggcagaatc ggattctact    120

gactttgacc tgctgtggta tctagagaat ctcagtgaca aggaatttca gagttttaag    180

aagtatctgg cacgcaagat tcttgatttc aaactgccac agtttccact gatacagatg    240

acaaaagaag aactggctaa cgtgttgcca atctcttatg agggacagta tatatggaat    300

atgctcttca gcatattttc aatgatgcgt aaggaagatc tttgtaggaa gatcattggc    360

agacgaaacc gcaatcagga ggcatgcaaa gctgtcatga ggagaaaatt catgctgcaa    420

tgggaaagtc acacttttgg aaaatttcat tataaatttt ttcgtgacgt ttcgtcagat    480

gtgttctaca tacttcaatt agcctatgat tctaccagct attattcagc aaacaatctc    540

aatgtgttcc tgatgggaga gagagcatct ggaaaaacta ttgttataaa tctggctgtg    600

ttgaggtgga tcaagggtga gatgtggcag aacatgatct cgtacgtcgt tcacctcact    660

tctcacgaaa taaaccagat gaccaacagc agcttggctg agctaatcgc caaggactgg    720

cctgacggcc aggctcccat tgcagacatc ctgtctgatc ccaagaaact ccttttcatc    780

ctcgaggact tggacaacat aagattcgag ttaaatgtca atgaaagtgc tttgtgtagt    840

aacagcaccc agaaagttcc cattccagtt ctcctggtca gtttgctgaa gagaaaaatg    900

gctccaggct gctggttcct catctcctca aggcccacac gtgggaataa tgtaaaaacg    960

ttcttgaaag aggtagattg ctgcacgacc ttgcagctgt cgaatgggaa gagggagata   1020

tattttaact ctttctttaa agaccgccag agggcgtcgg cagccctcca gcttgtacat   1080

gaggatgaaa tactcgtggg tctgtgccga gtcgccatct tatgctggat cacgtgtact   1140

gtcctgaagc ggcagatgga caaggggcgt gacttccagc tctgctgcca aacacccact   1200

gatctacatg cccactttct tgctgatgcg ttgacatcag aggctggact tactgccaat   1260

cagtatcacc taggtctcct aaaacgtctg tgtttgctgg ctgcaggagg actgtttctg   1320

agcaccctga atttcagtgg tgaagacctc agatgtgttg ggtttactga ggctgatgtc   1380

tctgtgttgc aggccgcgaa tattcttttg ccgagcaaca ctcataaaga ccgttacaag   1440

ttcatacact tgaacgtcca ggagttttgt acagccattg catttctgat ggcagtaccc   1500

aactatctga tcccctcagg cagcagagag tataaagaga agagagaaca atactctgac   1560

tttaatcaag tgtttacttt catttttggt cttctaaatg caaacaggag aaagattctt   1620

gagacatcct ttggatacca gctaccgatg gtagacagct tcaagtggta ctcggtggga   1680

tacatgaaac atttggaccg tgacccggaa aagttgacgc accatatgcc tttgttttac   1740

tgtctctatg agaatcggga agaagaattt gtgaagacga ttgtggatgc tctcatggag   1800

gttacagttt accttcaatc agacaaggat atgatggtct cattatactg tctggattac   1860

tgctgtcacc tgaggacact taagttgagc gttcagcgca tctttcaaaa caaagagcca   1920

cttataaggc caactgctag tcaaatgaag agccttgtct actggagaga gatctgctct   1980

cttttttata caatggagag cctccgggag ctgcatatct ttgacaatga ccttaatggt   2040

atttcagaaa ggattctgtc taaagccctg gagcattcta gctgtaaact tcgcacactc   2100

aagttgtcct atgtctcgac tgcttctggt tttgaagact tactcaaggc tttggctcgt   2160

aatcggagcc tgacatacct gagtatcaac tgtacgtcca tttccctaaa tatgttttca   2220

cttctgcatg acatcctgca cgagcccaca tgccaaataa gtcatctgag cttgatgaaa   2280

tgtgatttgc gagccagcga atgcgaagaa atcgcctctc tcctcatcag tggcgggagt   2340

ctgagaaaac tgaccttatc cagcaatccg ctgaggagcg acgggatgaa catactgtgt   2400

gatgccttgc ttcatcccaa ctgcactctt atatcactgg tgttagtctt ctgctgtctc   2460

actgaaaatt gctgcagcgc ccttggaaga gtgcttctgt tcagcccaac tctaagacaa   2520

ctagacctgt gtgtgaatcg cttaaaaaat tacggagtgt tgcatgtgac gtttcccttg   2580

ctgtttccaa cctgtcagtt agaggagctt catctgtctg gctgtttctt tagcagcgat   2640

atctgtcaat atattgccat agttattgct actaatgaaa aactgaggag cctggagatt   2700

gggagcaaca aaatagaaga tgcaggaatg cagctgctat gtggtggttt gagacatccc   2760

aactgcatgt tggtgaatat tgggctagaa gagtgcatgt taaccagtgc ctgctgtcga   2820

tctcttgcct ctgttcttac caccaacaaa acactagaaa gactcaactt gcttcaaaat   2880

cacttgggca atgatggagt tgcaaaactt cttgagagct tgatcagccc agattgtgta   2940

cttaaggtag ttgggcttcc attaactggc ctgaacacac aaacccagca gttgctgatg   3000

actgtaaagg aaagaaaacc cagtttgatc tttctgtctg aaacttggtc tttaaaggaa   3060

ggcagagaaa ttggtgtgac acctgcttct cagccaggtt caataatacc taattctaat   3120

ttggattaca tgtttttcaa atttcccaga atgtctgcag ccatgagaac gtcaaataca   3180

gcatctaggc aacccctttg atcatgttgt acgtaaacag tatttattat aaattactac   3240

cgtgactggg atgcaagaga attaggacta taattttcct atttgatgtg tgtgtgtgtg   3300

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgaccttg atccagtcaa ccacttcaaa   3360

ttcctacact gtctcaagag tattaaaagg attatatgaa gtaataaagg ataaaatgca   3420

ttggaaaaaa aaaaaaaaa                                                3439


<210>  3781
<211>  1033
<212>  PRT
<213>  Homosapiens

<400>  3781

Met Ala Glu Ser Asp Ser Thr Asp Phe Asp Leu Leu Trp Tyr Leu Glu 
1               5                   10                  15      


Asn Leu Ser Asp Lys Glu Phe Gln Ser Phe Lys Lys Tyr Leu Ala Arg 
            20                  25                  30          


Lys Ile Leu Asp Phe Lys Leu Pro Gln Phe Pro Leu Ile Gln Met Thr 
        35                  40                  45              


Lys Glu Glu Leu Ala Asn Val Leu Pro Ile Ser Tyr Glu Gly Gln Tyr 
    50                  55                  60                  


Ile Trp Asn Met Leu Phe Ser Ile Phe Ser Met Met Arg Lys Glu Asp 
65                  70                  75                  80  


Leu Cys Arg Lys Ile Ile Gly Arg Arg Asn Arg Asn Gln Glu Ala Cys 
                85                  90                  95      


Lys Ala Val Met Arg Arg Lys Phe Met Leu Gln Trp Glu Ser His Thr 
            100                 105                 110         


Phe Gly Lys Phe His Tyr Lys Phe Phe Arg Asp Val Ser Ser Asp Val 
        115                 120                 125             


Phe Tyr Ile Leu Gln Leu Ala Tyr Asp Ser Thr Ser Tyr Tyr Ser Ala 
    130                 135                 140                 


Asn Asn Leu Asn Val Phe Leu Met Gly Glu Arg Ala Ser Gly Lys Thr 
145                 150                 155                 160 


Ile Val Ile Asn Leu Ala Val Leu Arg Trp Ile Lys Gly Glu Met Trp 
                165                 170                 175     


Gln Asn Met Ile Ser Tyr Val Val His Leu Thr Ser His Glu Ile Asn 
            180                 185                 190         


Gln Met Thr Asn Ser Ser Leu Ala Glu Leu Ile Ala Lys Asp Trp Pro 
        195                 200                 205             


Asp Gly Gln Ala Pro Ile Ala Asp Ile Leu Ser Asp Pro Lys Lys Leu 
    210                 215                 220                 


Leu Phe Ile Leu Glu Asp Leu Asp Asn Ile Arg Phe Glu Leu Asn Val 
225                 230                 235                 240 


Asn Glu Ser Ala Leu Cys Ser Asn Ser Thr Gln Lys Val Pro Ile Pro 
                245                 250                 255     


Val Leu Leu Val Ser Leu Leu Lys Arg Lys Met Ala Pro Gly Cys Trp 
            260                 265                 270         


Phe Leu Ile Ser Ser Arg Pro Thr Arg Gly Asn Asn Val Lys Thr Phe 
        275                 280                 285             


Leu Lys Glu Val Asp Cys Cys Thr Thr Leu Gln Leu Ser Asn Gly Lys 
    290                 295                 300                 


Arg Glu Ile Tyr Phe Asn Ser Phe Phe Lys Asp Arg Gln Arg Ala Ser 
305                 310                 315                 320 


Ala Ala Leu Gln Leu Val His Glu Asp Glu Ile Leu Val Gly Leu Cys 
                325                 330                 335     


Arg Val Ala Ile Leu Cys Trp Ile Thr Cys Thr Val Leu Lys Arg Gln 
            340                 345                 350         


Met Asp Lys Gly Arg Asp Phe Gln Leu Cys Cys Gln Thr Pro Thr Asp 
        355                 360                 365             


Leu His Ala His Phe Leu Ala Asp Ala Leu Thr Ser Glu Ala Gly Leu 
    370                 375                 380                 


Thr Ala Asn Gln Tyr His Leu Gly Leu Leu Lys Arg Leu Cys Leu Leu 
385                 390                 395                 400 


Ala Ala Gly Gly Leu Phe Leu Ser Thr Leu Asn Phe Ser Gly Glu Asp 
                405                 410                 415     


Leu Arg Cys Val Gly Phe Thr Glu Ala Asp Val Ser Val Leu Gln Ala 
            420                 425                 430         


Ala Asn Ile Leu Leu Pro Ser Asn Thr His Lys Asp Arg Tyr Lys Phe 
        435                 440                 445             


Ile His Leu Asn Val Gln Glu Phe Cys Thr Ala Ile Ala Phe Leu Met 
    450                 455                 460                 


Ala Val Pro Asn Tyr Leu Ile Pro Ser Gly Ser Arg Glu Tyr Lys Glu 
465                 470                 475                 480 


Lys Arg Glu Gln Tyr Ser Asp Phe Asn Gln Val Phe Thr Phe Ile Phe 
                485                 490                 495     


Gly Leu Leu Asn Ala Asn Arg Arg Lys Ile Leu Glu Thr Ser Phe Gly 
            500                 505                 510         


Tyr Gln Leu Pro Met Val Asp Ser Phe Lys Trp Tyr Ser Val Gly Tyr 
        515                 520                 525             


Met Lys His Leu Asp Arg Asp Pro Glu Lys Leu Thr His His Met Pro 
    530                 535                 540                 


Leu Phe Tyr Cys Leu Tyr Glu Asn Arg Glu Glu Glu Phe Val Lys Thr 
545                 550                 555                 560 


Ile Val Asp Ala Leu Met Glu Val Thr Val Tyr Leu Gln Ser Asp Lys 
                565                 570                 575     


Asp Met Met Val Ser Leu Tyr Cys Leu Asp Tyr Cys Cys His Leu Arg 
            580                 585                 590         


Thr Leu Lys Leu Ser Val Gln Arg Ile Phe Gln Asn Lys Glu Pro Leu 
        595                 600                 605             


Ile Arg Pro Thr Ala Ser Gln Met Lys Ser Leu Val Tyr Trp Arg Glu 
    610                 615                 620                 


Ile Cys Ser Leu Phe Tyr Thr Met Glu Ser Leu Arg Glu Leu His Ile 
625                 630                 635                 640 


Phe Asp Asn Asp Leu Asn Gly Ile Ser Glu Arg Ile Leu Ser Lys Ala 
                645                 650                 655     


Leu Glu His Ser Ser Cys Lys Leu Arg Thr Leu Lys Leu Ser Tyr Val 
            660                 665                 670         


Ser Thr Ala Ser Gly Phe Glu Asp Leu Leu Lys Ala Leu Ala Arg Asn 
        675                 680                 685             


Arg Ser Leu Thr Tyr Leu Ser Ile Asn Cys Thr Ser Ile Ser Leu Asn 
    690                 695                 700                 


Met Phe Ser Leu Leu His Asp Ile Leu His Glu Pro Thr Cys Gln Ile 
705                 710                 715                 720 


Ser His Leu Ser Leu Met Lys Cys Asp Leu Arg Ala Ser Glu Cys Glu 
                725                 730                 735     


Glu Ile Ala Ser Leu Leu Ile Ser Gly Gly Ser Leu Arg Lys Leu Thr 
            740                 745                 750         


Leu Ser Ser Asn Pro Leu Arg Ser Asp Gly Met Asn Ile Leu Cys Asp 
        755                 760                 765             


Ala Leu Leu His Pro Asn Cys Thr Leu Ile Ser Leu Val Leu Val Phe 
    770                 775                 780                 


Cys Cys Leu Thr Glu Asn Cys Cys Ser Ala Leu Gly Arg Val Leu Leu 
785                 790                 795                 800 


Phe Ser Pro Thr Leu Arg Gln Leu Asp Leu Cys Val Asn Arg Leu Lys 
                805                 810                 815     


Asn Tyr Gly Val Leu His Val Thr Phe Pro Leu Leu Phe Pro Thr Cys 
            820                 825                 830         


Gln Leu Glu Glu Leu His Leu Ser Gly Cys Phe Phe Ser Ser Asp Ile 
        835                 840                 845             


Cys Gln Tyr Ile Ala Ile Val Ile Ala Thr Asn Glu Lys Leu Arg Ser 
    850                 855                 860                 


Leu Glu Ile Gly Ser Asn Lys Ile Glu Asp Ala Gly Met Gln Leu Leu 
865                 870                 875                 880 


Cys Gly Gly Leu Arg His Pro Asn Cys Met Leu Val Asn Ile Gly Leu 
                885                 890                 895     


Glu Glu Cys Met Leu Thr Ser Ala Cys Cys Arg Ser Leu Ala Ser Val 
            900                 905                 910         


Leu Thr Thr Asn Lys Thr Leu Glu Arg Leu Asn Leu Leu Gln Asn His 
        915                 920                 925             


Leu Gly Asn Asp Gly Val Ala Lys Leu Leu Glu Ser Leu Ile Ser Pro 
    930                 935                 940                 


Asp Cys Val Leu Lys Val Val Gly Leu Pro Leu Thr Gly Leu Asn Thr 
945                 950                 955                 960 


Gln Thr Gln Gln Leu Leu Met Thr Val Lys Glu Arg Lys Pro Ser Leu 
                965                 970                 975     


Ile Phe Leu Ser Glu Thr Trp Ser Leu Lys Glu Gly Arg Glu Ile Gly 
            980                 985                 990         


Val Thr Pro Ala Ser Gln Pro Gly  Ser Ile Ile Pro Asn  Ser Asn Leu 
        995                 1000                 1005             


Asp Tyr  Met Phe Phe Lys Phe  Pro Arg Met Ser Ala  Ala Met Arg 
    1010                 1015                 1020             


Thr Ser  Asn Thr Ala Ser Arg  Gln Pro Leu 
    1025                 1030             


<210>  3782
<211>  3339
<212>  DNA
<213>  Homosapiens

<400>  3782
atttatttat tgttcctggt cactgtctct ttgaggattg gtatctctgc tccagaaaag     60

atggcagcct ctttcttctc tgattttggt cttatgtggt atctggagga gctcaaaaag    120

gaggagttca ggaaatttaa agaacatctc aagcaaatga ctttgcagct tgaactcaag    180

cagattccct ggactgaggt caaaaaagca tcccgggaag aacttgcaaa cctcttgatc    240

aagcactatg aagaacaaca agcttggaac ataaccttaa gaatctttca aaagatggat    300

agaaaggatc tctgcatgaa ggtcatgagg gagagaacag gatacacaaa gacctatcaa    360

gctcacgcaa agcagaaatt cagccgctta tggtccagca agtctgtcac tgagattcac    420

ctatactttg aggaggaagt caagcaagaa gaatgtgacc atttggaccg cctttttgct    480

cccaaggaaa ctgggaaaca gccacgtaca gtgattattc aaggaccaca aggaattgga    540

aaaacgacac tcctgatgaa gctgatgatg gcctggtcgg acaacaagat ctttcgggat    600

aggttcctgt acacgttcta tttctgctgc agagaactga gggagttgcc gccaacgagt    660

ttggctgact tgatttccag agagtggcct gaccccgctg ctcctataac agagatcgtg    720

tctcaaccgg agagactctt gttcgtcatc gacagcttcg aagagctgca gggcggcttg    780

aacgaacccg attcggatct gtgtggtgac ttgatggaga aacggccggt gcaggtgctt    840

ctgagcagtt tgctgaggaa gaagatgctc ccggaggcct ccctgctcat cgccatcaaa    900

cccgtgtgcc cgaaggagct ccgggatcag gtgacgatct cagaaatcta ccagccccgg    960

ggattcaacg agagtgatag gttagtgtat ttctgctgtt tcttcaaaga cccgaaaaga   1020

gccatggaag ccttcaatct tgtaagagaa agtgaacagc tgttttccat atgccaaatc   1080

ccgctcctct gctggatcct gtgtaccagt ctgaagcaag agatgcagaa aggaaaagac   1140

ctggccctga cctgccagag cactacctct gtgtactcct ctttcgtctt taacctgttc   1200

acacctgagg gtgccgaggg cccgactccg caaacccagc accagctgaa ggccctgtgc   1260

tccctggctg cagagggtat gtggacagac acatttgagt tttgtgaaga cgacctccgg   1320

agaaatgggg ttgttgacgc tgacatccct gcgctgctgg gcaccaagat acttctgaag   1380

tacggggagc gtgagagctc ctacgtgttc ctccacgtgt gtatccagga gttctgtgcc   1440

gccttgttct atttgctcaa gagccacctt gatcatcctc acccagctgt gagatgtgta   1500

caggaattgc tagttgccaa ttttgaaaaa gcaaggagag cacattggat ttttttgggg   1560

tgttttctaa ctggcctttt aaataaaaag gaacaagaaa aactggatgc gttttttggc   1620

ttccaactgt cccaagagat aaagcagcaa attcaccagt gcctgaagag cttaggggag   1680

cgtggcaatc ctcagggaca ggtggattcc ttggcgatat tttactgtct ctttgaaatg   1740

caggatcctg cctttgtgaa gcaggcagtg aacctcctcc aagaagctaa ctttcatatt   1800

attgacaacg tggacttggt ggtttctgcc tactgcttaa aatactgctc cagcttgagg   1860

aaactctgtt tttccgttca aaatgtcttt aagaaagagg atgaacacag ctctacgtcg   1920

gattacagcc tcatctgttg gcatcacatc tgctctgtgc tcaccaccag cgggcacctc   1980

agagagctcc aggtgcagga cagcaccctc agcgagtcga cctttgtgac ctggtgtaac   2040

cagctgaggc atcccagctg tcgccttcag aagcttggaa taaataacgt ttccttttct   2100

ggccagagtg ttctgctctt tgaggtgctc ttttatcagc cagacttgaa atacctgagc   2160

ttcaccctca cgaaactctc tcgtgatgac atcaggtccc tctgtgatgc cttgaactac   2220

ccagcaggca acgtcaaaga gctagcgctg gtaaattgtc acctctcacc cattgattgt   2280

gaagtccttg ctggccttct aaccaacaac aagaagctga cgtatctgaa tgtatcctgc   2340

aaccagttag acacaggcgt gccccttttg tgtgaagccc tgtgcagccc agacacggtc   2400

ctggtatacc tgatgttggc tttctgccac ctcagcgagc agtgctgcga atacatctct   2460

gaaatgcttc tgcgtaacaa gagcgtgcgc tatctagacc tcagtgccaa tgtcctgaag   2520

gacgaaggac tgaaaactct ctgcgaggcc ttgaaacatc cggactgctg cctggattca   2580

ctgtgtttgg taaaatgttt tatcactgct gctggctgtg aagacctcgc ctctgctctc   2640

atcagcaatc aaaacctgaa gattctgcaa attgggtgca atgaaatcgg agatgtgggt   2700

gtgcagctgt tgtgtcgggc tctgacgcat acggattgcc gcttagagat tcttgggttg   2760

gaagaatgtg ggttaacgag cacctgctgt aaggatctcg cgtctgttct cacctgcagt   2820

aagaccctgc agcagctcaa cctgaccttg aacaccttgg accacacagg ggtggttgta   2880

ctctgtgagg ccctgagaca cccagagtgt gccctgcagg tgctcgggct gagaaaaact   2940

gattttgatg aggaaaccca ggcacttctg acggctgagg aagagagaaa tcctaacctg   3000

accatcacag atgactgtga cacaatcaca agggtagaga tctgattgcg aggaacctgg   3060

gctctgactc gaacacctgc aaaggacagg gactgggacc gttacttaca tgacactgca   3120

cccaggagat acaaatcatt gacactctga gttgtgagat ttctggcacc ccattcatag   3180

atttgatatg atacacgtgg tttttatgtg ctctgtggcc ttggatgagt cactgaaagg   3240

ccttcatggt ctctcggtct cacaaggacc tcttaacccc tcaataaagt gttacatttc   3300

taaacattgg aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                          3339


<210>  3783
<211>  994
<212>  PRT
<213>  Homosapiens

<400>  3783

Met Ala Ala Ser Phe Phe Ser Asp Phe Gly Leu Met Trp Tyr Leu Glu 
1               5                   10                  15      


Glu Leu Lys Lys Glu Glu Phe Arg Lys Phe Lys Glu His Leu Lys Gln 
            20                  25                  30          


Met Thr Leu Gln Leu Glu Leu Lys Gln Ile Pro Trp Thr Glu Val Lys 
        35                  40                  45              


Lys Ala Ser Arg Glu Glu Leu Ala Asn Leu Leu Ile Lys His Tyr Glu 
    50                  55                  60                  


Glu Gln Gln Ala Trp Asn Ile Thr Leu Arg Ile Phe Gln Lys Met Asp 
65                  70                  75                  80  


Arg Lys Asp Leu Cys Met Lys Val Met Arg Glu Arg Thr Gly Tyr Thr 
                85                  90                  95      


Lys Thr Tyr Gln Ala His Ala Lys Gln Lys Phe Ser Arg Leu Trp Ser 
            100                 105                 110         


Ser Lys Ser Val Thr Glu Ile His Leu Tyr Phe Glu Glu Glu Val Lys 
        115                 120                 125             


Gln Glu Glu Cys Asp His Leu Asp Arg Leu Phe Ala Pro Lys Glu Thr 
    130                 135                 140                 


Gly Lys Gln Pro Arg Thr Val Ile Ile Gln Gly Pro Gln Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Thr Leu Leu Met Lys Leu Met Met Ala Trp Ser Asp Asn Lys 
                165                 170                 175     


Ile Phe Arg Asp Arg Phe Leu Tyr Thr Phe Tyr Phe Cys Cys Arg Glu 
            180                 185                 190         


Leu Arg Glu Leu Pro Pro Thr Ser Leu Ala Asp Leu Ile Ser Arg Glu 
        195                 200                 205             


Trp Pro Asp Pro Ala Ala Pro Ile Thr Glu Ile Val Ser Gln Pro Glu 
    210                 215                 220                 


Arg Leu Leu Phe Val Ile Asp Ser Phe Glu Glu Leu Gln Gly Gly Leu 
225                 230                 235                 240 


Asn Glu Pro Asp Ser Asp Leu Cys Gly Asp Leu Met Glu Lys Arg Pro 
                245                 250                 255     


Val Gln Val Leu Leu Ser Ser Leu Leu Arg Lys Lys Met Leu Pro Glu 
            260                 265                 270         


Ala Ser Leu Leu Ile Ala Ile Lys Pro Val Cys Pro Lys Glu Leu Arg 
        275                 280                 285             


Asp Gln Val Thr Ile Ser Glu Ile Tyr Gln Pro Arg Gly Phe Asn Glu 
    290                 295                 300                 


Ser Asp Arg Leu Val Tyr Phe Cys Cys Phe Phe Lys Asp Pro Lys Arg 
305                 310                 315                 320 


Ala Met Glu Ala Phe Asn Leu Val Arg Glu Ser Glu Gln Leu Phe Ser 
                325                 330                 335     


Ile Cys Gln Ile Pro Leu Leu Cys Trp Ile Leu Cys Thr Ser Leu Lys 
            340                 345                 350         


Gln Glu Met Gln Lys Gly Lys Asp Leu Ala Leu Thr Cys Gln Ser Thr 
        355                 360                 365             


Thr Ser Val Tyr Ser Ser Phe Val Phe Asn Leu Phe Thr Pro Glu Gly 
    370                 375                 380                 


Ala Glu Gly Pro Thr Pro Gln Thr Gln His Gln Leu Lys Ala Leu Cys 
385                 390                 395                 400 


Ser Leu Ala Ala Glu Gly Met Trp Thr Asp Thr Phe Glu Phe Cys Glu 
                405                 410                 415     


Asp Asp Leu Arg Arg Asn Gly Val Val Asp Ala Asp Ile Pro Ala Leu 
            420                 425                 430         


Leu Gly Thr Lys Ile Leu Leu Lys Tyr Gly Glu Arg Glu Ser Ser Tyr 
        435                 440                 445             


Val Phe Leu His Val Cys Ile Gln Glu Phe Cys Ala Ala Leu Phe Tyr 
    450                 455                 460                 


Leu Leu Lys Ser His Leu Asp His Pro His Pro Ala Val Arg Cys Val 
465                 470                 475                 480 


Gln Glu Leu Leu Val Ala Asn Phe Glu Lys Ala Arg Arg Ala His Trp 
                485                 490                 495     


Ile Phe Leu Gly Cys Phe Leu Thr Gly Leu Leu Asn Lys Lys Glu Gln 
            500                 505                 510         


Glu Lys Leu Asp Ala Phe Phe Gly Phe Gln Leu Ser Gln Glu Ile Lys 
        515                 520                 525             


Gln Gln Ile His Gln Cys Leu Lys Ser Leu Gly Glu Arg Gly Asn Pro 
    530                 535                 540                 


Gln Gly Gln Val Asp Ser Leu Ala Ile Phe Tyr Cys Leu Phe Glu Met 
545                 550                 555                 560 


Gln Asp Pro Ala Phe Val Lys Gln Ala Val Asn Leu Leu Gln Glu Ala 
                565                 570                 575     


Asn Phe His Ile Ile Asp Asn Val Asp Leu Val Val Ser Ala Tyr Cys 
            580                 585                 590         


Leu Lys Tyr Cys Ser Ser Leu Arg Lys Leu Cys Phe Ser Val Gln Asn 
        595                 600                 605             


Val Phe Lys Lys Glu Asp Glu His Ser Ser Thr Ser Asp Tyr Ser Leu 
    610                 615                 620                 


Ile Cys Trp His His Ile Cys Ser Val Leu Thr Thr Ser Gly His Leu 
625                 630                 635                 640 


Arg Glu Leu Gln Val Gln Asp Ser Thr Leu Ser Glu Ser Thr Phe Val 
                645                 650                 655     


Thr Trp Cys Asn Gln Leu Arg His Pro Ser Cys Arg Leu Gln Lys Leu 
            660                 665                 670         


Gly Ile Asn Asn Val Ser Phe Ser Gly Gln Ser Val Leu Leu Phe Glu 
        675                 680                 685             


Val Leu Phe Tyr Gln Pro Asp Leu Lys Tyr Leu Ser Phe Thr Leu Thr 
    690                 695                 700                 


Lys Leu Ser Arg Asp Asp Ile Arg Ser Leu Cys Asp Ala Leu Asn Tyr 
705                 710                 715                 720 


Pro Ala Gly Asn Val Lys Glu Leu Ala Leu Val Asn Cys His Leu Ser 
                725                 730                 735     


Pro Ile Asp Cys Glu Val Leu Ala Gly Leu Leu Thr Asn Asn Lys Lys 
            740                 745                 750         


Leu Thr Tyr Leu Asn Val Ser Cys Asn Gln Leu Asp Thr Gly Val Pro 
        755                 760                 765             


Leu Leu Cys Glu Ala Leu Cys Ser Pro Asp Thr Val Leu Val Tyr Leu 
    770                 775                 780                 


Met Leu Ala Phe Cys His Leu Ser Glu Gln Cys Cys Glu Tyr Ile Ser 
785                 790                 795                 800 


Glu Met Leu Leu Arg Asn Lys Ser Val Arg Tyr Leu Asp Leu Ser Ala 
                805                 810                 815     


Asn Val Leu Lys Asp Glu Gly Leu Lys Thr Leu Cys Glu Ala Leu Lys 
            820                 825                 830         


His Pro Asp Cys Cys Leu Asp Ser Leu Cys Leu Val Lys Cys Phe Ile 
        835                 840                 845             


Thr Ala Ala Gly Cys Glu Asp Leu Ala Ser Ala Leu Ile Ser Asn Gln 
    850                 855                 860                 


Asn Leu Lys Ile Leu Gln Ile Gly Cys Asn Glu Ile Gly Asp Val Gly 
865                 870                 875                 880 


Val Gln Leu Leu Cys Arg Ala Leu Thr His Thr Asp Cys Arg Leu Glu 
                885                 890                 895     


Ile Leu Gly Leu Glu Glu Cys Gly Leu Thr Ser Thr Cys Cys Lys Asp 
            900                 905                 910         


Leu Ala Ser Val Leu Thr Cys Ser Lys Thr Leu Gln Gln Leu Asn Leu 
        915                 920                 925             


Thr Leu Asn Thr Leu Asp His Thr Gly Val Val Val Leu Cys Glu Ala 
    930                 935                 940                 


Leu Arg His Pro Glu Cys Ala Leu Gln Val Leu Gly Leu Arg Lys Thr 
945                 950                 955                 960 


Asp Phe Asp Glu Glu Thr Gln Ala Leu Leu Thr Ala Glu Glu Glu Arg 
                965                 970                 975     


Asn Pro Asn Leu Thr Ile Thr Asp Asp Cys Asp Thr Ile Thr Arg Val 
            980                 985                 990         


Glu Ile 
        


<210>  3784
<211>  413
<212>  DNA
<213>  Homosapiens

<400>  3784
agaacccact gcctcctgat gaagtcccta ctgttcaccc ttgcagtttt tatgctcctg     60

gcccaattgg tctcaggtaa ttggtatgtg aaaaagtgtc taaacgacgt tggaatttgc    120

aagaagaagt gcaaacctga agagatgcat gtaaagaatg gttgggcaat gtgcggcaaa    180

caaagggact gctgtgttcc agctgacaga cgtgctaatt atcctgtttt ctgtgtccag    240

acaaagacta caagaatttc aacagtaaca gcaacaacag caacaacaac tttgatgatg    300

actactgctt cgatgtcttc gatggctcct acccccgttt ctcccactgg ttgaacattc    360

cagcctctgt ctcctgctct aggatccccg actcattaaa gcaaagaggc tta           413


<210>  3785
<211>  111
<212>  PRT
<213>  Homosapiens

<400>  3785

Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln 
1               5                   10                  15      


Leu Val Ser Gly Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly 
            20                  25                  30          


Ile Cys Lys Lys Lys Cys Lys Pro Glu Glu Met His Val Lys Asn Gly 
        35                  40                  45              


Trp Ala Met Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Arg 
    50                  55                  60                  


Arg Ala Asn Tyr Pro Val Phe Cys Val Gln Thr Lys Thr Thr Arg Ile 
65                  70                  75                  80  


Ser Thr Val Thr Ala Thr Thr Ala Thr Thr Thr Leu Met Met Thr Thr 
                85                  90                  95      


Ala Ser Met Ser Ser Met Ala Pro Thr Pro Val Ser Pro Thr Gly 
            100                 105                 110     


<210>  3786
<211>  439
<212>  DNA
<213>  Homosapiens

<400>  3786
atggggctct tcatgatcat tgcaattctg ctgttccaga aacccacagt aaccgaacaa     60

cttaagaagt gctggaataa ctatgtacaa ggacattgca ggaaaatctg cagagtaaat    120

gaagtgcctg aggcactatg tgaaaatggg agatactgtt gcctcaatat caaggaactg    180

gaagcatgta aaaaaattac aaagccacct cgtccaaagc cagcaacact tgcactgact    240

cttcaagact atgttacaat aatagaaaat ttcccaagcc tgaagacaca gtctacataa    300

atcaaataca atttcgtttt cacttgcttc tcaacctagt ctaataaact aaggtgatga    360

gatatacatc ttcttccttt tggtttcttg atccttaaaa tgaccttcga gcatattcta    420

ataaagtgca ttgccagtt                                                 439


<210>  3787
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  3787

Met Gly Leu Phe Met Ile Ile Ala Ile Leu Leu Phe Gln Lys Pro Thr 
1               5                   10                  15      


Val Thr Glu Gln Leu Lys Lys Cys Trp Asn Asn Tyr Val Gln Gly His 
            20                  25                  30          


Cys Arg Lys Ile Cys Arg Val Asn Glu Val Pro Glu Ala Leu Cys Glu 
        35                  40                  45              


Asn Gly Arg Tyr Cys Cys Leu Asn Ile Lys Glu Leu Glu Ala Cys Lys 
    50                  55                  60                  


Lys Ile Thr Lys Pro Pro Arg Pro Lys Pro Ala Thr Leu Ala Leu Thr 
65                  70                  75                  80  


Leu Gln Asp Tyr Val Thr Ile Ile Glu Asn Phe Pro Ser Leu Lys Thr 
                85                  90                  95      


Gln Ser Thr 
            


<210>  3788
<211>  672
<212>  DNA
<213>  Homosapiens

<400>  3788
caaccatgaa gctccttttt cctatctttg ccagcctcat gctacagtac caggtgaaca     60

cagaatttat tggcttgaga cgctgtttaa tgggtttggg gagatgcagg gatcactgca    120

atgtggatga aaaagagata cagaaatgca agatgaaaaa atgttgtgtt ggaccaaaag    180

tggttaaatt gattaaaaac tacctgcaat atggaacacc aaatgtactt aatgaagacg    240

tccaagaaat gctaaaacct gccaagaatt ctagtgctgt gatacaaaga aaacatattt    300

tatctgttct cccccaaatc aaaagcacta gcttttttgc taataccaac tttgtcatca    360

ttccaaatgc cacccctatg aactctgcca ccatcagcac tatgacccca ggacagatca    420

catacactgc tacttctacc aagagtaaca ccaaagaaag cagagattct gccactgcct    480

cgccaccacc agcaccacct ccaccaaaca tactgccaac accatcactg gagctagagg    540

aagcagaaga gcagtaatgt ggatctttcc cttaaaactc caagttcctc tctatttttg    600

ctatctataa aatgacatag aactgtttcc tctgtcatca gtcattcaat aaacactgtt    660

tgagcaccta ca                                                        672


<210>  3789
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  3789

Met Lys Leu Leu Phe Pro Ile Phe Ala Ser Leu Met Leu Gln Tyr Gln 
1               5                   10                  15      


Val Asn Thr Glu Phe Ile Gly Leu Arg Arg Cys Leu Met Gly Leu Gly 
            20                  25                  30          


Arg Cys Arg Asp His Cys Asn Val Asp Glu Lys Glu Ile Gln Lys Cys 
        35                  40                  45              


Lys Met Lys Lys Cys Cys Val Gly Pro Lys Val Val Lys Leu Ile Lys 
    50                  55                  60                  


Asn Tyr Leu Gln Tyr Gly Thr Pro Asn Val Leu Asn Glu Asp Val Gln 
65                  70                  75                  80  


Glu Met Leu Lys Pro Ala Lys Asn Ser Ser Ala Val Ile Gln Arg Lys 
                85                  90                  95      


His Ile Leu Ser Val Leu Pro Gln Ile Lys Ser Thr Ser Phe Phe Ala 
            100                 105                 110         


Asn Thr Asn Phe Val Ile Ile Pro Asn Ala Thr Pro Met Asn Ser Ala 
        115                 120                 125             


Thr Ile Ser Thr Met Thr Pro Gly Gln Ile Thr Tyr Thr Ala Thr Ser 
    130                 135                 140                 


Thr Lys Ser Asn Thr Lys Glu Ser Arg Asp Ser Ala Thr Ala Ser Pro 
145                 150                 155                 160 


Pro Pro Ala Pro Pro Pro Pro Asn Ile Leu Pro Thr Pro Ser Leu Glu 
                165                 170                 175     


Leu Glu Glu Ala Glu Glu Gln 
            180             


<210>  3790
<211>  2119
<212>  DNA
<213>  Homosapiens

<400>  3790
ctccattaaa ccaccaccag ctccccaagc caccccttca gccatgaagt tcctgctcct     60

ggtcttggca gccctcggat tcctgaccca ggtgatccca gccagtgcag gtgggtcaaa    120

atgtgtgagt aacaccccag gatactgcag gacatgttgc cactgggggg agacagcatt    180

gttcatgtgc aacgcttcca gaaaatgctg catcagctac tccttcctgc cgaagcctga    240

cctaccacag ctcatcggta accactggca atcaaggaga agaaacacac aaaggaaaga    300

caagaagcaa caaacgaccg taacatcata ataaccactg ctatcgcctc caccaactca    360

gagaaatatc atttccacag ttccaattcc tcctacattg ctgagtacta gccaaggctc    420

ctctttatgg ggcagatatc tatagccaac cccaaaactt ctgtcttcta tcattctgtc    480

attcatctag taactaattt ggagtttgta tctatcttac gagaacaatc atcatgcaga    540

ttcgtccaca ggggatctgt cagtttgggt cctccaaatg aaaaatgtca agacagaatt    600

ggacatgcaa aagattgact gggagaacac acctctgatg gacaaaggtg agacagagca    660

gccacaggca gggagagcct tcagactgca acgctggcct gatacgtgtc aaaggagaga    720

gggatagagg aggattgaat agaaggagac taagactgca gctctaagaa agtctcagcc    780

aaacagatgg ggaggcccaa agcaaggctt gcccctcaga ggagctcacg cagggcagga    840

atagccaggt tctcatatcc caggggttca gacttggctg agaacagccc ctggagaaca    900

tggggtgact gctaccatag gtctggaagt atgaggctgt ccaccaacta tccccttgaa    960

gcaagttctc ttgaaaggaa atctaaacag tgcaccccca tggctgccac ggagtataag   1020

gagggagaga aaggagctga aagtctaggt ttggccagct aggtagactg acttgtgagg   1080

tatttattta ttcatttgag taacaaagca gacagaatac atagccacca ttggtagtac   1140

accccaaaag caaggatggc atgatgctgg tgactcaaac gtgcctactc atggtgtcaa   1200

attggcataa tcctcttggg aagctgtgtg gaaataagca cagagaagca gaactctaat   1260

tgcttaatcc actaaacatt acttctggga attggctcat cataaattat ccaagagaaa   1320

gcacaaagtt atgggcacaa aggttttcca tataatatta tttaaaatgc tgagaaaatg   1380

aaaaaatcta aatggtgaaa tatatactaa tgccatctat aaatacaaac aaatagaatg   1440

tttatagaat aatggaacat aataacatta ttcaaaattg catttatgct atagttgtca   1500

aaattgtctc cttatatgat acaaaactca tgaaaattat gacttttttg tttggttgga   1560

aagcagaatt atgcataaat ttcctcttac agttcgatgc ccattagttt tatataacat   1620

ttatttgaca cgtactgact tctatctgag aagaacaaac caaaacactc aggcctaaat   1680

aattaaaaac ggtcctaaaa actagcaaac cagataagaa aagatgttaa tgcccattcc   1740

ctaacttatg tcttagacca aaattaattc tagatggttt taaaatgaca gtgtaaaagt   1800

aaagtattaa aagattgtgt ggtcaaatat tcaatttaag agcaaggaaa ttcttataaa   1860

tataacaata gaggcagaac tcatgtaaga ataaattgat taggtggtat taaatattaa   1920

gttcttatgt atgtcaaaag atatcatttt gaaattcatc catcttattg ggtattgcag   1980

gagttcattc ctttttgttt ataaatactc ttccgtcata tgaatagtat tcatttgtat   2040

actggtttgt tgatggacat ttgggttgtt cccagtttat ggctattaca aataaagctt   2100

ctatgaacat ttatgtaca                                                2119


<210>  3791
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  3791

Met Lys Phe Leu Leu Leu Val Leu Ala Ala Leu Gly Phe Leu Thr Gln 
1               5                   10                  15      


Val Ile Pro Ala Ser Ala Gly Gly Ser Lys Cys Val Ser Asn Thr Pro 
            20                  25                  30          


Gly Tyr Cys Arg Thr Cys Cys His Trp Gly Glu Thr Ala Leu Phe Met 
        35                  40                  45              


Cys Asn Ala Ser Arg Lys Cys Cys Ile Ser Tyr Ser Phe Leu Pro Lys 
    50                  55                  60                  


Pro Asp Leu Pro Gln Leu Ile Gly Asn His Trp Gln Ser Arg Arg Arg 
65                  70                  75                  80  


Asn Thr Gln Arg Lys Asp Lys Lys Gln Gln Thr Thr Val Thr Ser 
                85                  90                  95  


<210>  3792
<211>  1555
<212>  DNA
<213>  Homosapiens

<400>  3792
aaagcatcgg gtctcgggac ttctgagtgg cctgggttac cgcgcgatct acactgagac     60

aaggaagttg gaaaagccga gtagttatac cagaagatca gggtctcaca gactcgcaac    120

ttctcttcca ttttccccaa tggcgcatgt cttacaaaaa cccaagcact ctgggactca    180

ctccatagtc caggagttcc aggttccgga ttatgttcca tggcagcagt ccaagcagga    240

aaccaagcca tctactctgc ctccagtcca acaagccaac agccttcata caagcaaaat    300

gaagactttg actagggtcc aaccagtgtt tcacttcaag cccactacgg tggtgacaag    360

ctgccagccg aagaatccaa gagaactaca tagaaggcgg aagttggacc ctgggaagat    420

gcatgccaaa atctggttaa tgaagacgtc gctcaggagc gggagggccg ctctgcgaga    480

gctccgaagc cgtgagaact tcctcagcaa gctcaaccgg gagctgatcg agaccatcca    540

ggagatggag aacagcacga ccctgcacgt gcgggccctg ctgcagcagc aggacacctt    600

ggcgaccatc atcgacatct tggagtactc aaacaagaag aggctgcagc aattgaaatc    660

tgagcttcag gagtgggaag aaaagaagaa atgcaagatg agctatcttg agcagcaggc    720

agagcagctg aatgccaaga ttgagaagac ccaggaggaa gtgaacttcc tgagcactta    780

catggaccat gagtattcca tcaagtctgt ccagatctcc actcttatgc gccagctgca    840

gcaggttaag gacagccagc aggatgagct ggatgacctc ggtgagatgc gcagaaaggt    900

cctggaatcc ttgtccgaca agattcagaa gaagaagaaa aaaattctga gttctgtggt    960

ggcggaaacc cagcgtccct atgaagaggc tctcctacag aagatgtggg aaagccagga   1020

cttcctgaaa tgcatgcaaa ggttcagaga atttattgac cagtttgagg agaacatgcc   1080

tgtattaagg gccgaggtgg aagagctcca agcccagacc cgggaacccc gagaggtcat   1140

atttgaggat gttctgcttc ggagacccaa gtgcacccca gacatggatg tcatcctcaa   1200

cattcctgtg gaagagccac tacccttcta gatggcagtg ccatgggccg ccctcccctc   1260

ctgctctctt cccagcacct ggagccttgg atcatttact tccaggaccg gatctccatt   1320

cagaccctga tctacagtct ccctgctccc tctgcccttc ctccctcttt ctttccctcc   1380

ctccctccct cccttcttcc ccccttccct tccctcctcc ttccttcctc ctctccctcc   1440

ctccctcctt tctttcttcc tgtggttttt tcctctcttc ttcccttctt tctggttggt   1500

gctgctgggc caggtgggaa tttctgatta aatctgctat tcctttttta ccaat        1555


<210>  3793
<211>  363
<212>  PRT
<213>  Homosapiens

<400>  3793

Met Ala His Val Leu Gln Lys Pro Lys His Ser Gly Thr His Ser Ile 
1               5                   10                  15      


Val Gln Glu Phe Gln Val Pro Asp Tyr Val Pro Trp Gln Gln Ser Lys 
            20                  25                  30          


Gln Glu Thr Lys Pro Ser Thr Leu Pro Pro Val Gln Gln Ala Asn Ser 
        35                  40                  45              


Leu His Thr Ser Lys Met Lys Thr Leu Thr Arg Val Gln Pro Val Phe 
    50                  55                  60                  


His Phe Lys Pro Thr Thr Val Val Thr Ser Cys Gln Pro Lys Asn Pro 
65                  70                  75                  80  


Arg Glu Leu His Arg Arg Arg Lys Leu Asp Pro Gly Lys Met His Ala 
                85                  90                  95      


Lys Ile Trp Leu Met Lys Thr Ser Leu Arg Ser Gly Arg Ala Ala Leu 
            100                 105                 110         


Arg Glu Leu Arg Ser Arg Glu Asn Phe Leu Ser Lys Leu Asn Arg Glu 
        115                 120                 125             


Leu Ile Glu Thr Ile Gln Glu Met Glu Asn Ser Thr Thr Leu His Val 
    130                 135                 140                 


Arg Ala Leu Leu Gln Gln Gln Asp Thr Leu Ala Thr Ile Ile Asp Ile 
145                 150                 155                 160 


Leu Glu Tyr Ser Asn Lys Lys Arg Leu Gln Gln Leu Lys Ser Glu Leu 
                165                 170                 175     


Gln Glu Trp Glu Glu Lys Lys Lys Cys Lys Met Ser Tyr Leu Glu Gln 
            180                 185                 190         


Gln Ala Glu Gln Leu Asn Ala Lys Ile Glu Lys Thr Gln Glu Glu Val 
        195                 200                 205             


Asn Phe Leu Ser Thr Tyr Met Asp His Glu Tyr Ser Ile Lys Ser Val 
    210                 215                 220                 


Gln Ile Ser Thr Leu Met Arg Gln Leu Gln Gln Val Lys Asp Ser Gln 
225                 230                 235                 240 


Gln Asp Glu Leu Asp Asp Leu Gly Glu Met Arg Arg Lys Val Leu Glu 
                245                 250                 255     


Ser Leu Ser Asp Lys Ile Gln Lys Lys Lys Lys Lys Ile Leu Ser Ser 
            260                 265                 270         


Val Val Ala Glu Thr Gln Arg Pro Tyr Glu Glu Ala Leu Leu Gln Lys 
        275                 280                 285             


Met Trp Glu Ser Gln Asp Phe Leu Lys Cys Met Gln Arg Phe Arg Glu 
    290                 295                 300                 


Phe Ile Asp Gln Phe Glu Glu Asn Met Pro Val Leu Arg Ala Glu Val 
305                 310                 315                 320 


Glu Glu Leu Gln Ala Gln Thr Arg Glu Pro Arg Glu Val Ile Phe Glu 
                325                 330                 335     


Asp Val Leu Leu Arg Arg Pro Lys Cys Thr Pro Asp Met Asp Val Ile 
            340                 345                 350         


Leu Asn Ile Pro Val Glu Glu Pro Leu Pro Phe 
        355                 360             


<210>  3794
<211>  2773
<212>  DNA
<213>  Homosapiens

<400>  3794
ggaggatgct gggaaggagg taaaatggcc accggcggcg gcgcggagga agagaggaaa     60

cgggggcggc cgcagcttct gccccccgcg cggcccgcgg cccggggcga ggaggccgac    120

ggcggccgcg agaagatggg ctgggcccag gtggtgaaga atctagccga gaagaagggc    180

gaattccgcg agccgcggcc gccgcggcgg gaggaggaaa gcggcggcgg tggagggagc    240

gccgggctcg gcggccccgc gggcctggcg gcgccggacc tcggcgactt cccaccggct    300

ggccgcgggg atccgaaggg ccgtcggaga gatccggccg gcgaggcggt ggacccccgc    360

aaaaagaagg gcgctgcgga ggcgggcagg aggaagaagg ccgaggcggc ggcggccgcc    420

atggcgaccc cggccaggcc cggcgaggcc gaggacgcgg ccgagcggcc cctccaggat    480

gagccggcgg cggcggcagg cccgggcaag ggtcgcttcc tcgtccgcat ctgtttccag    540

ggagacgagg gcgcctgccc gacccgggac ttcgtggtag gagcgcttat cctgcgctcc    600

atcggcatgg acccgagcga catctacgcg gtcatccaga tcccgggcag ccgcgaattc    660

gacgtgagct tccgctcagc ggagaagctg gccctgttcc tacgcgtcta cgaggagaag    720

cgggagcagg aggactgctg ggagaacttt gtggtgctgg ggcggagcaa gtccagcttg    780

aagacgctct tcatcctctt ccggaacgag acggtggacg tggaggacat tgtgacttgg    840

ctcaagcgcc actgcgacgt gctggccgtg ccggtgaaag tgaccgacag gtttgggatc    900

tggaccgggg agtacaaatg cgagatcgag ctgcgccagg gggagggcgg ggtcaggcac    960

ttgccagggg ccttcttcct gggggccgag aggggctaca gctggtacaa ggggcagccc   1020

aagacatgct ttaaatgtgg ttcccggacc cacatgagcg gcagctgcac gcaggacagg   1080

tgcttcaggt gcggggagga ggggcacctg agcccttact gccggaaggg catcgtgtgc   1140

aacctctgtg gcaagcgagg acacgccttt gcccagtgtc ccaaagcagt gcacaattcc   1200

gtggcagctc agctaaccgg cgtggccggg cactaaacac ccgcctgcct gccagggtga   1260

acacacagcc agcttatccc tcttaagtgc caaaactttt ttttaaacca ttttttatcg   1320

tttttgaagg agatcttttt aaaacctaca agagacatct ctctatgcct tcttaaaccg   1380

agtttactcc atttcagcct gttctgaatt ggtgactctg tcaccaataa cgactgcgga   1440

gaactgtagc gtgcagatgt gttgcccctc ccttttaaaa ttttattttc gtttttctat   1500

tgggtatttg ttttgtttct tgtacttttt ctctctctcc ttgcccccct cccgccctcc   1560

ccgccccata ccttttcttc ccctggattt tcaccctttg ggctgccttg ctcatcttta   1620

tgccccagca ctaggtacgg ggcccaacac gtggtaggca ctccatcagt gtttgctgaa   1680

ttgaaaacat tgttgactgt ggcttctatc agagtgtcta ccttttgcag ctcttcccct   1740

ccctcattta atttgctgct tttaatctac gtggtctgag aatttgtgaa accagtgttg   1800

ttagaagtgt atataatctg aatcaataag ctctgaatgg tggccaaggg cctctcttat   1860

ggcacaaaga tgcatggact tcatgacagc tcttttggtg gctcagaagc cattttttat   1920

agaatcatgg aatctagaat attcctgctg gaaagaacct gagagttggt ttggaccaat   1980

tccctggttt tccagcagat gaaacaggcc caaagaggtt aaatgactgg gtgaaaatca   2040

catagctgtc tggtgccaga gccagcctat agtagagtcc cctgacccca agcccggtgc   2100

tcattccact acctctcaca cttcacaaca atttcctcaa cacttgaggg cccagaaagt   2160

ctgatctctc cagaatgatc agcccagagg aatgctgaga aatcacctgg aggagggagc   2220

agaaagagaa ggtttttaag gaggggcttc tgaatacttg ggagatacgg aacggaccaa   2280

ggaccacact ccagggtgca ttcgttgctc cctggggcac cacttctgga ttacagtgtg   2340

ccaggtcctt tggaggccct accccttccc cattcattgc caccagtgag aaatgggggt   2400

gcccctgtgt aaagaaacct accaaaggtt tacatttgca ccttagcctc aatagctacg   2460

aaccctagag aagcagctag ctggagctca tgtgcaactc ctgattctca ggagaaagat   2520

ggattttaac ccaaaattat gagtgagctg ttaactctaa aatgtacttg ggagataggc   2580

caagcgagag gtcatgggcc aactaagtgt tatccagtag aaaagacagt acactgcttt   2640

tcttttagtg tttgcttttc ctttgctata tgttttgcta tttccttgtg gcttagaatg   2700

taaaattgat tgttaaaagt tttgttctga ataaatattt atcttttgta ttgctaaaaa   2760

aaaaaaaaaa aaa                                                      2773


<210>  3795
<211>  403
<212>  PRT
<213>  Homosapiens

<400>  3795

Met Ala Thr Gly Gly Gly Ala Glu Glu Glu Arg Lys Arg Gly Arg Pro 
1               5                   10                  15      


Gln Leu Leu Pro Pro Ala Arg Pro Ala Ala Arg Gly Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Arg Glu Lys Met Gly Trp Ala Gln Val Val Lys Asn Leu Ala 
        35                  40                  45              


Glu Lys Lys Gly Glu Phe Arg Glu Pro Arg Pro Pro Arg Arg Glu Glu 
    50                  55                  60                  


Glu Ser Gly Gly Gly Gly Gly Ser Ala Gly Leu Gly Gly Pro Ala Gly 
65                  70                  75                  80  


Leu Ala Ala Pro Asp Leu Gly Asp Phe Pro Pro Ala Gly Arg Gly Asp 
                85                  90                  95      


Pro Lys Gly Arg Arg Arg Asp Pro Ala Gly Glu Ala Val Asp Pro Arg 
            100                 105                 110         


Lys Lys Lys Gly Ala Ala Glu Ala Gly Arg Arg Lys Lys Ala Glu Ala 
        115                 120                 125             


Ala Ala Ala Ala Met Ala Thr Pro Ala Arg Pro Gly Glu Ala Glu Asp 
    130                 135                 140                 


Ala Ala Glu Arg Pro Leu Gln Asp Glu Pro Ala Ala Ala Ala Gly Pro 
145                 150                 155                 160 


Gly Lys Gly Arg Phe Leu Val Arg Ile Cys Phe Gln Gly Asp Glu Gly 
                165                 170                 175     


Ala Cys Pro Thr Arg Asp Phe Val Val Gly Ala Leu Ile Leu Arg Ser 
            180                 185                 190         


Ile Gly Met Asp Pro Ser Asp Ile Tyr Ala Val Ile Gln Ile Pro Gly 
        195                 200                 205             


Ser Arg Glu Phe Asp Val Ser Phe Arg Ser Ala Glu Lys Leu Ala Leu 
    210                 215                 220                 


Phe Leu Arg Val Tyr Glu Glu Lys Arg Glu Gln Glu Asp Cys Trp Glu 
225                 230                 235                 240 


Asn Phe Val Val Leu Gly Arg Ser Lys Ser Ser Leu Lys Thr Leu Phe 
                245                 250                 255     


Ile Leu Phe Arg Asn Glu Thr Val Asp Val Glu Asp Ile Val Thr Trp 
            260                 265                 270         


Leu Lys Arg His Cys Asp Val Leu Ala Val Pro Val Lys Val Thr Asp 
        275                 280                 285             


Arg Phe Gly Ile Trp Thr Gly Glu Tyr Lys Cys Glu Ile Glu Leu Arg 
    290                 295                 300                 


Gln Gly Glu Gly Gly Val Arg His Leu Pro Gly Ala Phe Phe Leu Gly 
305                 310                 315                 320 


Ala Glu Arg Gly Tyr Ser Trp Tyr Lys Gly Gln Pro Lys Thr Cys Phe 
                325                 330                 335     


Lys Cys Gly Ser Arg Thr His Met Ser Gly Ser Cys Thr Gln Asp Arg 
            340                 345                 350         


Cys Phe Arg Cys Gly Glu Glu Gly His Leu Ser Pro Tyr Cys Arg Lys 
        355                 360                 365             


Gly Ile Val Cys Asn Leu Cys Gly Lys Arg Gly His Ala Phe Ala Gln 
    370                 375                 380                 


Cys Pro Lys Ala Val His Asn Ser Val Ala Ala Gln Leu Thr Gly Val 
385                 390                 395                 400 


Ala Gly His 
            


<210>  3796
<211>  4645
<212>  DNA
<213>  Homosapiens

<400>  3796
ccgcggcgga gccagaggct gcaggaagag cccgcggggg cccggagggt gcgattcctc     60

ggcccccgca aaacaatgtg tgttgtgagc caggacgcaa cttgccggag gcggcggggg    120

cgcgccgagc ccgcctgaga ccgcgctgac cttctccccc cgccgtccgt tgggcccgag    180

cgcccagctc ctcgctcccc agttcgcggg ggccgggccg agccgcgggg cggggccgcc    240

cctccgtcgc cgctgcctcc tcccccaccc ccagccgcgg aggatgcgga cggcccccgg    300

cggcgtctag cggccccggg cccaggcgcg atggtgcagc agcggggcgc gagggccaag    360

cgggacggcg ggccgccgcc cccgggaccc gggccggccg aggagggggc gcgcgagccc    420

ggctggtgca agaccccgag cggccacatc aagaggccga tgaacgcatt catggtgtgg    480

tcgcagcacg aacggcggaa gatcatggac cagtggcccg acatgcacaa cgccgagatc    540

tccaagcgcc tgggccgccg ctggcagctg ctgcaggact cggagaagat cccgttcgtg    600

cgggaggcgg agcggctgcg gctcaagcac atggcggatt acccggacta caagtaccgg    660

ccgcgcaaaa agagcaaggg ggcgcccgcc aaggcgcggc cccgcccccc cggtggtagc    720

ggtggcggca gccggctcaa gcccgggccg cagctgcctg gccgcggggg ccgccgagca    780

gcgggagggc ctttgggggg cggggcggcg gcgcccgagg acgacgatga agacgacgac    840

gaggagctgc tggaagtgcg cctggtcgag accccggggc gggagctgtg gaggatggtc    900

ccggcgggac gggccgctcg gggacaagcg gagcgcgccc aagggccgtc gggcgagggg    960

gcggccgccg ccgccgccgc ctccccgaca ccgtcggagg acgaggagcc ggaggaagag   1020

gaggaggagg cggcagcggc tgaggaaggt gaagaggaga cggtggcgtc gggggaggag   1080

tcgctgggct ttctgtccag gctgccccct ggcccggccg gcctggactg cagcgccctg   1140

gatcgcgacc cggacctgca gcctccctcg ggcacgtcgc acttcgagtt cccggactac   1200

tgcacccccg aggttaccga gatgatcgcg ggggactggc gcccgtctag catcgcagac   1260

ctggttttca cctactgagc ccaccgtcag cggggcgcgc acgcccccaa accagctgtt   1320

tacatacagg aatcaggtat tggggcccct cggaggccga ggctggcacc ccatctcccg   1380

cgcagcctgc cccctcctgg acgtgcccat cccccctcag atccagacat gcccctcccc   1440

cgcagacaca ccccaaggca gcccaacccc caccccttcc ccgacaccca agcccctccc   1500

cacgtcgccc cctcctgcac agccaccagc agccagcccc ctccgataca cctcccgtcc   1560

tctcctacag acctgcaccc ctcccccctt ttgcacacgc ccctcctcgt ggccggagga   1620

cccgccccct cctttgctcc ggaatctctc ctccctcgcc cggcccgcct tctctgggtt   1680

aggggggcga tgcggccggg tggcaacgca cgcgcctcct gcgcccctcc cttccctggg   1740

gggaggggcg cacccctttt atccccggag cgctagggcc cgcccctccg ctggggccca   1800

cccccttcgt gcgcatgctt aatgcttctg gggaggaggg ggctggtccc agcggagccg   1860

cactcttcgc ccgctccggg caaaagcggg ggcgagtgta gagcgatcct gggaaatcct   1920

ttgatccggg agccctaggt ttcctctcca gccaacgggg cgtcgctgcc ttaatgggag   1980

gagcactcgg aagggttggt ttgggcctga aactctccca agtggcatag ccccttttcc   2040

ggtatggggt ctcctacacc cacgcgcacc acctctccgg tcgcgtggct gcctctacag   2100

cctacctata cgtccctttt tccccccaac tgggaattga gaggtaaggt ctttctctgg   2160

aaatccagca gtagaggaag ggaccaccca agaaaactaa aaaccaaggc accttaccag   2220

tctgtctggg gacaggatcc ctgctgcacc ttccccaccc cctcctggga agtgccccct   2280

cacctcaggg cacccgcaac ctgggctcct ccctgagcgc accggccctt cctgtcaccc   2340

aggtccaccc tcagtactca agctgcagta tacagcggga aaaactgagg cactttggtg   2400

ctaggggttt gggactgagg cgtggagagc agatgtgatg gcaggaagac tctcgctttt   2460

aaacatctgg tttgggagag accatcgact tggccagtga gactgagaat ggattccgag   2520

tagtgatggg ccgtttgcac ctcggttttt ccacgtgaga aatggggaga acgctgctgt   2580

taggaggaag ttgtgtccag ttcagggtgc cctcgggagc cctgtccctg ttgctgtggc   2640

ccctctcacg ccgccatctc tctgccccgc cccgcccctc cggcctcccc acacccccct   2700

tgccctcact acctgtatct caccggcgtg tgttcaccct cccgggtggc tcacacactc   2760

tcattcacac acacaaatct caggaacaaa cggtcccaga gtcctccgga cccctgccca   2820

gggtctctgc aggtctctgc cccacgcgtt cccgtcgctg acaaagccac cagctgcctc   2880

ctttaagctt ggtgctccgg ctctgggcct ttcttgcgct ctattttttt tttttttttt   2940

tttaagaaaa acaacaacaa caaaaaaaga caatgaaaaa aaaaacgtca tgtgagtgaa   3000

gagatgtcac tgtctgtggt cttggagaac tagtctcgta gctgaggggt ggggtccctc   3060

tgtctggggc actggcaccc acagcaggac tccgccagtc tgatgccagg actgaataaa   3120

gtgtatttgc cccgaccttg ccctgtggtt ctgcatgtct gtgctcttcc tcaaccctcc   3180

ctaaacagtt tgccagattc aagtccgtgt gatttgggcc cgagctgggt gtcccagggc   3240

aagccacctt gcctgtctag gcctctatgt caggactccc tggccttcat gaagaatagc   3300

aaactcatcc ctgtagggac caggcaggta acatagacga gtgactctgg gtggacagtg   3360

gtgtcatgac ccacttcaag gggcctacct cctgccagtt gtgaccctgt gggaatgcag   3420

tccacagtgg ccaggtggcc agatttttca agaaaagctg gatggatgtt tctgagtcat   3480

cttaatttca aaatgagact catattttaa aatttctgtg ggccaaatga aacaagtatg   3540

caggcaggtc tggtccgagg gggctggctt ggccatgcct ttctgtgcct ttaatgagga   3600

ctaagaagca agattgggcc acactgtctg gactcaaagc ccagctccac cactgagcac   3660

ccgtgtgact ctttccatat gtataacgtg gggataataa taatagctgc ttcacaggat   3720

gaaatgaagt ttgaggtgag aagcattcac catggtgccc atcgtgttac tccattgtca   3780

gaggaggaaa cggggtcagg caggaaagca acttaaagga gggcctgcaa gcagccaggg   3840

tcagagacag ggcttggttc tgcttcctgg tgaagcatgg cttcggggtg ctgcctctcc   3900

ctccctgttt gaatctgcag attgtgttag gcccccagct gagggcctgg agtggtggga   3960

ttggtcccag tgcctggcgc acattggcct gcagagtaga ttaactgaat gaccaaagag   4020

caacagaagt ctagtgattc ttgtctttga ggttctgact ggtgttttac aactgagtcc   4080

aaggcttttc cctcctttgt ccctctgaca cccctccccc taattctcat ctgtcagatc   4140

cagtgtattc ctaagctggg acaaagcctc tgttttccca gtaggagcca gggctgagtg   4200

tggaaattac agtgactgct tcttctcagc ttctctggtt gaaagcaagc tggcgaagta   4260

agaggaggta gagttgagaa ggtgtggaag atagggacag ctgcccccag aactcccttc   4320

aagggaggac ttccccagct atgggaagtg ccatcagggt ggccgcagct gcagagagcc   4380

acttcacctg agaccacgcc cttcctgggg cagcctgtat ctggtgtctg agtgaggcat   4440

ggtataaaca cctggtcatt tcaatccaac atgggacgga cactgacaga cagtactccc   4500

agcaggccca ggccagccag ggcttcgtca ggcctgcagc acaatttgac ttcctatgcc   4560

caggcctgct tcctcttctt cctcttcttt tcacaggtgc ttattcctaa taaacatctt   4620

gcaacccaaa aaaaaaaaaa aaaaa                                         4645


<210>  3797
<211>  315
<212>  PRT
<213>  Homosapiens

<400>  3797

Met Val Gln Gln Arg Gly Ala Arg Ala Lys Arg Asp Gly Gly Pro Pro 
1               5                   10                  15      


Pro Pro Gly Pro Gly Pro Ala Glu Glu Gly Ala Arg Glu Pro Gly Trp 
            20                  25                  30          


Cys Lys Thr Pro Ser Gly His Ile Lys Arg Pro Met Asn Ala Phe Met 
        35                  40                  45              


Val Trp Ser Gln His Glu Arg Arg Lys Ile Met Asp Gln Trp Pro Asp 
    50                  55                  60                  


Met His Asn Ala Glu Ile Ser Lys Arg Leu Gly Arg Arg Trp Gln Leu 
65                  70                  75                  80  


Leu Gln Asp Ser Glu Lys Ile Pro Phe Val Arg Glu Ala Glu Arg Leu 
                85                  90                  95      


Arg Leu Lys His Met Ala Asp Tyr Pro Asp Tyr Lys Tyr Arg Pro Arg 
            100                 105                 110         


Lys Lys Ser Lys Gly Ala Pro Ala Lys Ala Arg Pro Arg Pro Pro Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Arg Leu Lys Pro Gly Pro Gln Leu Pro Gly 
    130                 135                 140                 


Arg Gly Gly Arg Arg Ala Ala Gly Gly Pro Leu Gly Gly Gly Ala Ala 
145                 150                 155                 160 


Ala Pro Glu Asp Asp Asp Glu Asp Asp Asp Glu Glu Leu Leu Glu Val 
                165                 170                 175     


Arg Leu Val Glu Thr Pro Gly Arg Glu Leu Trp Arg Met Val Pro Ala 
            180                 185                 190         


Gly Arg Ala Ala Arg Gly Gln Ala Glu Arg Ala Gln Gly Pro Ser Gly 
        195                 200                 205             


Glu Gly Ala Ala Ala Ala Ala Ala Ala Ser Pro Thr Pro Ser Glu Asp 
    210                 215                 220                 


Glu Glu Pro Glu Glu Glu Glu Glu Glu Ala Ala Ala Ala Glu Glu Gly 
225                 230                 235                 240 


Glu Glu Glu Thr Val Ala Ser Gly Glu Glu Ser Leu Gly Phe Leu Ser 
                245                 250                 255     


Arg Leu Pro Pro Gly Pro Ala Gly Leu Asp Cys Ser Ala Leu Asp Arg 
            260                 265                 270         


Asp Pro Asp Leu Gln Pro Pro Ser Gly Thr Ser His Phe Glu Phe Pro 
        275                 280                 285             


Asp Tyr Cys Thr Pro Glu Val Thr Glu Met Ile Ala Gly Asp Trp Arg 
    290                 295                 300                 


Pro Ser Ser Ile Ala Asp Leu Val Phe Thr Tyr 
305                 310                 315 


<210>  3798
<211>  2042
<212>  DNA
<213>  Homosapiens

<400>  3798
gcaggcagag agatgaggaa actgagaccc agaaaggtgg aagcacttgt ctaaggtcac     60

gcctccagga agcagtgtgt ccacgactcc agtccaagtg gtcaggctcc agagcccaca    120

gtcccagggg tccatgatgc cgagctgcaa tcgttcctgc agctgcagcc gcggccccag    180

cgtggaggat ggcaagtggt atggggtccg ctcctacctg cacctcttct atgaggactg    240

tgcaggcact gctctcagcg acgaccctga gggacctccg gtcctgtgcc cccgccggcc    300

ctggccctca ctgtgttgga agatcagcct gtcctcgggg accctgcttc tgctgctggg    360

tgtggcggct ctgaccactg gctatgcagt gccccccaag ctggagggca tcggtgaggg    420

tgagttcctg gtgttggatc agcgggcagc cgactacaac caggccctgg gcacctgtcg    480

cctggcaggc acagcgctct gtgtggcagc tggagttctg ctcgccatct gcctcttctg    540

ggccatgata ggctggctga gccaggacac caaggcagag cccttggacc ccgaagccga    600

cagccacgtg gaggtcttcg gggatgagcc agagcagcag ttgtcaccca ttttccgcaa    660

tgccagtggc cagtcatggt tctcgccacc cgccagcccc tttgggcaat cttctgtgca    720

gactatccag cccaagaggg actcctgagc tgcccacatg gcctaagatg tgggtcctgg    780

atccttcccc cttctcacca taaccccctc tcagtgtttc cccaacttct ccctttagag    840

cccaactcca ggtcaaatct ggagctcaaa tcccagtgct ccctccccag gagtggggcc    900

ccaactcttc caagatacca gcattcctca agtcctccca aaacttccta cccacaccct    960

cttcccaagg ccctcagggg cagaaaacat ctccttcaac ccgtccccac tccttcctct   1020

gcatgacctt gggcaaaccc ttgccctttc aagccatcag ctcctgcctc tctgccatga   1080

gggctttgga tcagattcct cttctcgcca ggatgaggac acgcactgcc ctccatagac   1140

acagatgaag gggtgggggt cattcagctc gaatgggtcc cagatgctca cttggccttt   1200

ccctgcagga tgagtgaaga cgtttgcctc tcacagtgtg tcttctacct gcattttggc   1260

atcagagccc cccagcccac ccaccacagg caattactag ccctagttga taggtgaggt   1320

gggtgaagaa ggctggaggt gacatgtccg aggtcacaca acaaagcagc atgcaggaac   1380

tagaaacaca tcttcagcct cctcctgggc cagctcttgt gctacaggtg gggcggagcc   1440

agcccctcac cttcctggtt ccctgagggt cctcagggtg gaggacaggt ttggcccaga   1500

aagactagcc agaggcctga tggtcccagg tggctctgga tatactttgg atatggattt   1560

aaatggtctc taagagccgg gggtaggggg caggaaaagt gggttgtctt tgcccctcaa   1620

agtccaccta cctagaaacc aagcccacgg tcttggccgt gaccctgata ataaatgggc   1680

tctctcagag gcgccagccc ctccctcccc agccggaggc gtcatctctc ttctgtacca   1740

ctagagggag ctctgatgca gctggagagc agcgctcaag gctctcgccc ctcccctccc   1800

taacccttac cttcagtctc caccagcctg aagggcctcc taggggatcc tcaggcggcc   1860

cccaccaggg cacaccctac tgtccttgtg cctcacgccc cctcctcatc ctgcacccct   1920

tccatcccac cttccctttc aataaacagc tgggatggaa aaaaaaaaaa agaaaaaaaa   1980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2040

aa                                                                  2042


<210>  3799
<211>  204
<212>  PRT
<213>  Homosapiens

<400>  3799

Met Met Pro Ser Cys Asn Arg Ser Cys Ser Cys Ser Arg Gly Pro Ser 
1               5                   10                  15      


Val Glu Asp Gly Lys Trp Tyr Gly Val Arg Ser Tyr Leu His Leu Phe 
            20                  25                  30          


Tyr Glu Asp Cys Ala Gly Thr Ala Leu Ser Asp Asp Pro Glu Gly Pro 
        35                  40                  45              


Pro Val Leu Cys Pro Arg Arg Pro Trp Pro Ser Leu Cys Trp Lys Ile 
    50                  55                  60                  


Ser Leu Ser Ser Gly Thr Leu Leu Leu Leu Leu Gly Val Ala Ala Leu 
65                  70                  75                  80  


Thr Thr Gly Tyr Ala Val Pro Pro Lys Leu Glu Gly Ile Gly Glu Gly 
                85                  90                  95      


Glu Phe Leu Val Leu Asp Gln Arg Ala Ala Asp Tyr Asn Gln Ala Leu 
            100                 105                 110         


Gly Thr Cys Arg Leu Ala Gly Thr Ala Leu Cys Val Ala Ala Gly Val 
        115                 120                 125             


Leu Leu Ala Ile Cys Leu Phe Trp Ala Met Ile Gly Trp Leu Ser Gln 
    130                 135                 140                 


Asp Thr Lys Ala Glu Pro Leu Asp Pro Glu Ala Asp Ser His Val Glu 
145                 150                 155                 160 


Val Phe Gly Asp Glu Pro Glu Gln Gln Leu Ser Pro Ile Phe Arg Asn 
                165                 170                 175     


Ala Ser Gly Gln Ser Trp Phe Ser Pro Pro Ala Ser Pro Phe Gly Gln 
            180                 185                 190         


Ser Ser Val Gln Thr Ile Gln Pro Lys Arg Asp Ser 
        195                 200                 


<210>  3800
<211>  2469
<212>  DNA
<213>  Homosapiens

<400>  3800
gacagagcaa gactctgtct caaaaaaaaa aaaaaaaaga gcaaattttt tttccaaggt     60

gatagggaga gtccgtggct gatgtctgca ctgaccagac gcccctaggg ggccagcgag    120

ggcgggtccc aggtgcagcg gatgcagagg agagaggccc gggcgcggcg cgggggatgg    180

tgcgatcccg ggcccgaggg catcagacgg cggctgatta gctccggttt gcatcacccg    240

gaccggggga ttagctccgg tttgcatcac ccggaccggg ggattagctc cggtttgcat    300

cacccggacc gggggccggg cgcgcacgag actcgcagcg gaagtggagg cggctccgcg    360

cgcgtccgct gctaggaccc gggcagggct ggagctgggc tgggatcccg agctcggcag    420

cagcgcagcg ggccggccca cctgctggtg ccctggaggc tctgagcccc ggcggcgccc    480

gggcccacgc ggaacgacgg ggcgagatgc gagccacccc tctggctgct cctgcgggtt    540

ccctgtccag gaagaagcgg ttggagttgg atgacaactt agataccgag cgtcccgtcc    600

agaaacgagc tcgaagtggg ccccagccca gactgccccc ctgcctgttg cccctgagcc    660

cacctactgc tccagatcgt gcaactgctg tggccactgc ctcccgtctt gggccctatg    720

tcctcctgga gcccgaggag ggcgggcggg cctaccaggc cctgcactgc cctacaggca    780

ctgagtatac ctgcaaggtg taccccgtcc aggaagccct ggccgtgctg gagccctatg    840

cgcggctgcc cccgcacaag catgtggctc ggcccactga ggtcctggct ggtacccagc    900

tcctctacgc ctttttcact cggacccatg gggacatgca cagcctggtg cgaagccgcc    960

accgtatccc tgagcctgag gctgccgtgc tcttccgcca gatggccacc gccctggcgc   1020

actgtcacca gcacggtctg gtcctgcgtg atctcaagct gtgtcgcttt gtcttcgctg   1080

accgtgagag gaagaagctg gtgctggaga acctggagga ctcctgcgtg ctgactgggc   1140

cagatgattc cctgtgggac aagcacgcgt gcccagccta cgtgggacct gagatactca   1200

gctcacgggc ctcatactcg ggcaaggcag ccgatgtctg gagcctgggc gtggcgctct   1260

tcaccatgct ggccggccac taccccttcc aggactcgga gcctgtcctg ctcttcggca   1320

agatccgccg cggggcctac gccttgcctg caggcctctc ggcccctgcc cgctgtctgg   1380

ttcgctgcct ccttcgtcgg gagccagctg aacggctcac agccacaggc atcctcctgc   1440

acccctggct gcgacaggac ccgatgccct tagccccaac ccgatcccat ctctgggagg   1500

ctgcccaggt ggtccctgat ggactggggc tggacgaagc cagggaagag gagggagaca   1560

gagaagtggt tctgtatggc taggaccacc ctactacacg ctcagctgcc aacagtggat   1620

tgagtttggg ggtagctcca agccttctcc tgcctctgaa ctgagccaaa ccttcagtgc   1680

cttccagaag ggagaaaggc agaagcctgt gtggagtgtg ctgtgtacac atctgctttg   1740

ttccacacac atgcagttcc tgcttgggtg cttatcaggt gccaagccct gttctcggtg   1800

ctgggagtac agcagtgagc aaaggagaca atattccctg ctcacagaga tgacaaactg   1860

gcatccttga gctgacaaca cttttccatg accataggtc actgtctaca ctgggtacac   1920

tttgtaccag tgtcggcctc cactgatgct ggtgctcagg cacctctgtc caaggacaat   1980

ccctttcaca aacaaaccag ctgcctttgt atcttgtacc ttttcagaga aagggaggta   2040

tccctgtgcc aaaggctcca ggcctctccc ctgcaactca ggacccaagc ccagctcact   2100

ctgggaactg tgttcccagc atctctgtcc tcttgattaa gagattctcc ttccaggcct   2160

aagcctggga tttgggccag agataagaat ccaaactatg aggctagttc ttgtctaact   2220

caagactgtt ctggaatgag ggtccaggcc tgtcaaccat ggggcttctg acctgagcac   2280

caaggttgag ggacaggatt aggcagggtc tgtcctgtgg ccacctggaa agtcccaggt   2340

gggactcttc tggggacact tggggtccac aatcccaggt ccatactcta ggttttggat   2400

accatgagta tgtatgttta cctgtgccta ataaaggaga attatgaaat aaaaaaaaaa   2460

aaaaaaaaa                                                           2469


<210>  3801
<211>  358
<212>  PRT
<213>  Homosapiens

<400>  3801

Met Arg Ala Thr Pro Leu Ala Ala Pro Ala Gly Ser Leu Ser Arg Lys 
1               5                   10                  15      


Lys Arg Leu Glu Leu Asp Asp Asn Leu Asp Thr Glu Arg Pro Val Gln 
            20                  25                  30          


Lys Arg Ala Arg Ser Gly Pro Gln Pro Arg Leu Pro Pro Cys Leu Leu 
        35                  40                  45              


Pro Leu Ser Pro Pro Thr Ala Pro Asp Arg Ala Thr Ala Val Ala Thr 
    50                  55                  60                  


Ala Ser Arg Leu Gly Pro Tyr Val Leu Leu Glu Pro Glu Glu Gly Gly 
65                  70                  75                  80  


Arg Ala Tyr Gln Ala Leu His Cys Pro Thr Gly Thr Glu Tyr Thr Cys 
                85                  90                  95      


Lys Val Tyr Pro Val Gln Glu Ala Leu Ala Val Leu Glu Pro Tyr Ala 
            100                 105                 110         


Arg Leu Pro Pro His Lys His Val Ala Arg Pro Thr Glu Val Leu Ala 
        115                 120                 125             


Gly Thr Gln Leu Leu Tyr Ala Phe Phe Thr Arg Thr His Gly Asp Met 
    130                 135                 140                 


His Ser Leu Val Arg Ser Arg His Arg Ile Pro Glu Pro Glu Ala Ala 
145                 150                 155                 160 


Val Leu Phe Arg Gln Met Ala Thr Ala Leu Ala His Cys His Gln His 
                165                 170                 175     


Gly Leu Val Leu Arg Asp Leu Lys Leu Cys Arg Phe Val Phe Ala Asp 
            180                 185                 190         


Arg Glu Arg Lys Lys Leu Val Leu Glu Asn Leu Glu Asp Ser Cys Val 
        195                 200                 205             


Leu Thr Gly Pro Asp Asp Ser Leu Trp Asp Lys His Ala Cys Pro Ala 
    210                 215                 220                 


Tyr Val Gly Pro Glu Ile Leu Ser Ser Arg Ala Ser Tyr Ser Gly Lys 
225                 230                 235                 240 


Ala Ala Asp Val Trp Ser Leu Gly Val Ala Leu Phe Thr Met Leu Ala 
                245                 250                 255     


Gly His Tyr Pro Phe Gln Asp Ser Glu Pro Val Leu Leu Phe Gly Lys 
            260                 265                 270         


Ile Arg Arg Gly Ala Tyr Ala Leu Pro Ala Gly Leu Ser Ala Pro Ala 
        275                 280                 285             


Arg Cys Leu Val Arg Cys Leu Leu Arg Arg Glu Pro Ala Glu Arg Leu 
    290                 295                 300                 


Thr Ala Thr Gly Ile Leu Leu His Pro Trp Leu Arg Gln Asp Pro Met 
305                 310                 315                 320 


Pro Leu Ala Pro Thr Arg Ser His Leu Trp Glu Ala Ala Gln Val Val 
                325                 330                 335     


Pro Asp Gly Leu Gly Leu Asp Glu Ala Arg Glu Glu Glu Gly Asp Arg 
            340                 345                 350         


Glu Val Val Leu Tyr Gly 
        355             


<210>  3802
<211>  2570
<212>  DNA
<213>  Homosapiens

<400>  3802
gggagtccgg ggacccgcga tcagccccgg aggacggggt ggggtcgccc caaacaggag     60

cgccgggacc gctgggaccc cgcactcggc gtccgccgcc gccgggtagc cgggcagtgg    120

aggtcccgga tgaggcgaca atttttccgg ccccccctcc cagtcccgcc ccacttccgg    180

ggccgccact ttcactttct cttccgccga agccgctccc cttgcgaaga actggggcct    240

cccgggagga gagagggctt tgccttgaaa cccgggacgc caggggcgct cccgcaagtg    300

ggggtcctcc gggacttgga acgccccggc tgggtggtgt ccgggcgtcc tttccccgct    360

tcttcccacc tcggctggtc ccgtttcctc ctgcgcccag tgcggacctg tctcggcgcc    420

cgctgccctc tcaccgcccc acgcaggatc ccggcctggt caccgggcag tgtgatgctt    480

cccgactgcc gcggggacag cgaggcacac acagggcttg ggccgcgccg gaggccacac    540

ggcctggctg agttgctcct ggtctcccgc ctctcccagg cgacccggag gtagcatttc    600

ccaggaggca cggtcccccc cagggggatg ggcacagcca cgccagatgg acgagaagac    660

caagaaaggc tgtgggtgag cgtggaggat gctcagatgc acaccgtcac catctggctc    720

acagtgcgcc ctgatatgac agtggcgtct ctcaaggaca tggtttttct ggactatggc    780

ttcccaccag tcttgcagca gtgggtgatt gggcagcggc tggcacgaga ccaggagacc    840

ctgcactccc atggggtgcg gcagaatggg gacagtgcct acctctatct gctgtcagcc    900

cgcaacacct ccctcaaccc tcaggagctg cagcgggagc ggcagctgcg gatgctggaa    960

gatctgggct tcaaggacct cacgctgcag ccgcggggcc ctctggagcc aggcccccca   1020

aagcccgggg tcccccagga acccggacgg gggcagccag atgcagtgcc tgagccccca   1080

ccggtgggct ggcagtgccc cgggtgcacc ttcatcaaca agcccacgcg gcctggctgt   1140

gagatgtgct gccgggcgcg ccccgaggcc taccaggtcc ccgcctcata ccagcccgac   1200

gaggaggagc gagcgcgcct ggcgggcgag gaggaggcgc tgcgtcagta ccagcagcgg   1260

aagcagcagc agcaggaggg gaactacctg cagcacgtcc agctggacca gaggagcctg   1320

gtgctgaaca cggagcccgc cgagtgcccc gtgtgctact cggtgctggc gcccggcgag   1380

gccgtggtgc tgcgtgagtg tctgcacacc ttctgcaggg agtgcctgca gggcaccatc   1440

cgcaacagcc aggaggcgga ggtctcctgc cccttcattg acaacaccta ctcgtgctcg   1500

ggcaagctgc tggagaggga gatcaaggcg ctcctgaccc ctgaggatta ccagcgattt   1560

ctagacctgg gcatctccat tgctgaaaac cgcagtgcct tcagctacca ttgcaagacc   1620

ccagattgca agggatggtg cttctttgag gatgatgtca atgagttcac ctgccctgtg   1680

tgtttccacg tcaactgcct gctctgcaag gccatccatg agcagatgaa ctgcaaggag   1740

tatcaggagg acctggccct gcgggctcag aacgatgtgg ctgcccggca gacgacagag   1800

atgctgaagg tgatgctgca gcagggcgag gccatgcgct gcccccagtg ccagatcgtg   1860

gtacagaaga aggacggctg cgactggatc cgctgcaccg tctgccacac cgagatctgc   1920

tgggtcacca agggcccacg ctggggccct gggggcccag gagacaccag cgggggctgc   1980

cgctgcaggg taaatgggat tccttgccac ccaagctgtc agaactgcca ctgagctaaa   2040

gatggtgggg ccacatgctg acccagcccc acatccacat tctgttagaa tgtagctcag   2100

ggagcttcgt ggacggcctt gcttgctgta gcgttgtagg ggccctgcct gcactgcggt   2160

tgtccacggt cacatctgcc ccagtgcctt tgtccttccc ttggggcttg ccggccagac   2220

ttctctcccc tgcggctccc acctctgcct gaccccagcc ttaaacatag cccctggcca   2280

gaggccttgc tgggtggagc ctctgtgtga ctccatactc ctcccaccac aacactcatc   2340

tgtcaaacac caagcactct cagcctcccc gccttcagct gtcagctttc tggggctaac   2400

ttctctgcct ttgtggttgg aggcctgagg cctcttggaa ctcttgctaa cctgttcaga   2460

gccaggaagg agactgcaca gttttgaaag cacagcccgt caggtccggc tctgcgtctc   2520

cctctctgca gcctgtgtaa gctattataa ttaaaatggt tttccgggaa              2570


<210>  3803
<211>  468
<212>  PRT
<213>  Homosapiens

<400>  3803

Met Gly Thr Ala Thr Pro Asp Gly Arg Glu Asp Gln Glu Arg Leu Trp 
1               5                   10                  15      


Val Ser Val Glu Asp Ala Gln Met His Thr Val Thr Ile Trp Leu Thr 
            20                  25                  30          


Val Arg Pro Asp Met Thr Val Ala Ser Leu Lys Asp Met Val Phe Leu 
        35                  40                  45              


Asp Tyr Gly Phe Pro Pro Val Leu Gln Gln Trp Val Ile Gly Gln Arg 
    50                  55                  60                  


Leu Ala Arg Asp Gln Glu Thr Leu His Ser His Gly Val Arg Gln Asn 
65                  70                  75                  80  


Gly Asp Ser Ala Tyr Leu Tyr Leu Leu Ser Ala Arg Asn Thr Ser Leu 
                85                  90                  95      


Asn Pro Gln Glu Leu Gln Arg Glu Arg Gln Leu Arg Met Leu Glu Asp 
            100                 105                 110         


Leu Gly Phe Lys Asp Leu Thr Leu Gln Pro Arg Gly Pro Leu Glu Pro 
        115                 120                 125             


Gly Pro Pro Lys Pro Gly Val Pro Gln Glu Pro Gly Arg Gly Gln Pro 
    130                 135                 140                 


Asp Ala Val Pro Glu Pro Pro Pro Val Gly Trp Gln Cys Pro Gly Cys 
145                 150                 155                 160 


Thr Phe Ile Asn Lys Pro Thr Arg Pro Gly Cys Glu Met Cys Cys Arg 
                165                 170                 175     


Ala Arg Pro Glu Ala Tyr Gln Val Pro Ala Ser Tyr Gln Pro Asp Glu 
            180                 185                 190         


Glu Glu Arg Ala Arg Leu Ala Gly Glu Glu Glu Ala Leu Arg Gln Tyr 
        195                 200                 205             


Gln Gln Arg Lys Gln Gln Gln Gln Glu Gly Asn Tyr Leu Gln His Val 
    210                 215                 220                 


Gln Leu Asp Gln Arg Ser Leu Val Leu Asn Thr Glu Pro Ala Glu Cys 
225                 230                 235                 240 


Pro Val Cys Tyr Ser Val Leu Ala Pro Gly Glu Ala Val Val Leu Arg 
                245                 250                 255     


Glu Cys Leu His Thr Phe Cys Arg Glu Cys Leu Gln Gly Thr Ile Arg 
            260                 265                 270         


Asn Ser Gln Glu Ala Glu Val Ser Cys Pro Phe Ile Asp Asn Thr Tyr 
        275                 280                 285             


Ser Cys Ser Gly Lys Leu Leu Glu Arg Glu Ile Lys Ala Leu Leu Thr 
    290                 295                 300                 


Pro Glu Asp Tyr Gln Arg Phe Leu Asp Leu Gly Ile Ser Ile Ala Glu 
305                 310                 315                 320 


Asn Arg Ser Ala Phe Ser Tyr His Cys Lys Thr Pro Asp Cys Lys Gly 
                325                 330                 335     


Trp Cys Phe Phe Glu Asp Asp Val Asn Glu Phe Thr Cys Pro Val Cys 
            340                 345                 350         


Phe His Val Asn Cys Leu Leu Cys Lys Ala Ile His Glu Gln Met Asn 
        355                 360                 365             


Cys Lys Glu Tyr Gln Glu Asp Leu Ala Leu Arg Ala Gln Asn Asp Val 
    370                 375                 380                 


Ala Ala Arg Gln Thr Thr Glu Met Leu Lys Val Met Leu Gln Gln Gly 
385                 390                 395                 400 


Glu Ala Met Arg Cys Pro Gln Cys Gln Ile Val Val Gln Lys Lys Asp 
                405                 410                 415     


Gly Cys Asp Trp Ile Arg Cys Thr Val Cys His Thr Glu Ile Cys Trp 
            420                 425                 430         


Val Thr Lys Gly Pro Arg Trp Gly Pro Gly Gly Pro Gly Asp Thr Ser 
        435                 440                 445             


Gly Gly Cys Arg Cys Arg Val Asn Gly Ile Pro Cys His Pro Ser Cys 
    450                 455                 460                 


Gln Asn Cys His 
465             


<210>  3804
<211>  2715
<212>  DNA
<213>  Homosapiens

<400>  3804
gggagtccgg ggacccgcga tcagccccgg aggacggggt ggggtcgccc caaacaggag     60

cgccgggacc gctgggaccc cgcactcggc gtccgccgcc gccgggtagc cgggcagtgg    120

aggtcccgga tgaggcgaca atttttccgg ccccccctcc cagtcccgcc ccacttccgg    180

ggccgccact ttcactttct cttccgccga agccgctccc cttgcgaaga actggggcct    240

cccgggagga gagagggctt tgccttgaaa cccgggacgc caggggcgct cccgcaagtg    300

ggggtcctcc gggacttgga acgccccggc tgggtggtgt ccgggcgtcc tttccccgct    360

tcttcccacc tcggctggtc ccgtttcctc ctgcgcccag tgcggacctg tctcggcgcc    420

cgctgccctc tcaccgcccc acgcaggatc ccggcctggt caccgggcag tgtgatgctt    480

cccgactgcc gcggggacag cgaggcacac acagggcttg ggccgcgccg gaggccacac    540

ggcctggctg agttgctcct ggtctcccgc ctctcccagg cgacccggag gtagcatttc    600

ccaggaggca cggtcccccc cagggggatg ggcacagcca cgccagatgg acgagaagac    660

caagaaagca gaggaaatgg ccctgagcct cacccgagca gtggcgggcg gggatgaaca    720

ggtggcaatg aagtgtgcca tctggctggc agagcaacgg gtgcccctga gtgtgcaact    780

gaagcctgag gtctccccaa cgcaggacat caggctgtgg gtgagcgtgg aggatgctca    840

gatgcacacc gtcaccatct ggctcacagt gcgccctgat atgacagtgg cgtctctcaa    900

ggacatggtt tttctggact atggcttccc accagtcttg cagcagtggg tgattgggca    960

gcggctggca cgagaccagg agaccctgca ctcccatggg gtgcggcaga atggggacag   1020

tgcctacctc tatctgctgt cagcccgcaa cacctccctc aaccctcagg agctgcagcg   1080

ggagcggcag ctgcggatgc tggaagatct gggcttcaag gacctcacgc tgcagccgcg   1140

gggccctctg gagccaggcc ccccaaagcc cggggtcccc caggaacccg gacgggggca   1200

gccagatgca gtgcctgagc ccccaccggt gggctggcag tgccccgggt gcaccttcat   1260

caacaagccc acgcggcctg gctgtgagat gtgctgccgg gcgcgccccg aggcctacca   1320

ggtccccgcc tcataccagc ccgacgagga ggagcgagcg cgcctggcgg gcgaggagga   1380

ggcgctgcgt cagtaccagc agcggaagca gcagcagcag gaggggaact acctgcagca   1440

cgtccagctg gaccagagga gcctggtgct gaacacggag cccgccgagt gccccgtgtg   1500

ctactcggtg ctggcgcccg gcgaggccgt ggtgctgcgt gagtgtctgc acaccttctg   1560

cagggagtgc ctgcagggca ccatccgcaa cagccaggag gcggaggtct cctgcccctt   1620

cattgacaac acctactcgt gctcgggcaa gctgctggag agggagatca aggcgctcct   1680

gacccctgag gattaccagc gatttctaga cctgggcatc tccattgctg aaaaccgcag   1740

tgccttcagc taccattgca agaccccaga ttgcaaggga tggtgcttct ttgaggatga   1800

tgtcaatgag ttcacctgcc ctgtgtgttt ccacgtcaac tgcctgctct gcaaggccat   1860

ccatgagcag atgaactgca aggagtatca ggaggacctg gccctgcggg ctcagaacga   1920

tgtggctgcc cggcagacga cagagatgct gaaggtgatg ctgcagcagg gcgaggccat   1980

gcgctgcccc cagtgccaga tcgtggtaca gaagaaggac ggctgcgact ggatccgctg   2040

caccgtctgc cacaccgaga tctgctgggt caccaagggc ccacgctggg gccctggggg   2100

cccaggagac accagcgggg gctgccgctg cagggtaaat gggattcctt gccacccaag   2160

ctgtcagaac tgccactgag ctaaagatgg tggggccaca tgctgaccca gccccacatc   2220

cacattctgt tagaatgtag ctcagggagc ttcgtggacg gccttgcttg ctgtagcgtt   2280

gtaggggccc tgcctgcact gcggttgtcc acggtcacat ctgccccagt gcctttgtcc   2340

ttcccttggg gcttgccggc cagacttctc tcccctgcgg ctcccacctc tgcctgaccc   2400

cagccttaaa catagcccct ggccagaggc cttgctgggt ggagcctctg tgtgactcca   2460

tactcctccc accacaacac tcatctgtca aacaccaagc actctcagcc tccccgcctt   2520

cagctgtcag ctttctgggg ctaacttctc tgcctttgtg gttggaggcc tgaggcctct   2580

tggaactctt gctaacctgt tcagagccag gaaggagact gcacagtttt gaaagcacag   2640

cccgtcaggt ccggctctgc gtctccctct ctgcagcctg tgtaagctat tataattaaa   2700

atggttttcc gggaa                                                    2715


<210>  3805
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  3805

Met Ala Leu Ser Leu Thr Arg Ala Val Ala Gly Gly Asp Glu Gln Val 
1               5                   10                  15      


Ala Met Lys Cys Ala Ile Trp Leu Ala Glu Gln Arg Val Pro Leu Ser 
            20                  25                  30          


Val Gln Leu Lys Pro Glu Val Ser Pro Thr Gln Asp Ile Arg Leu Trp 
        35                  40                  45              


Val Ser Val Glu Asp Ala Gln Met His Thr Val Thr Ile Trp Leu Thr 
    50                  55                  60                  


Val Arg Pro Asp Met Thr Val Ala Ser Leu Lys Asp Met Val Phe Leu 
65                  70                  75                  80  


Asp Tyr Gly Phe Pro Pro Val Leu Gln Gln Trp Val Ile Gly Gln Arg 
                85                  90                  95      


Leu Ala Arg Asp Gln Glu Thr Leu His Ser His Gly Val Arg Gln Asn 
            100                 105                 110         


Gly Asp Ser Ala Tyr Leu Tyr Leu Leu Ser Ala Arg Asn Thr Ser Leu 
        115                 120                 125             


Asn Pro Gln Glu Leu Gln Arg Glu Arg Gln Leu Arg Met Leu Glu Asp 
    130                 135                 140                 


Leu Gly Phe Lys Asp Leu Thr Leu Gln Pro Arg Gly Pro Leu Glu Pro 
145                 150                 155                 160 


Gly Pro Pro Lys Pro Gly Val Pro Gln Glu Pro Gly Arg Gly Gln Pro 
                165                 170                 175     


Asp Ala Val Pro Glu Pro Pro Pro Val Gly Trp Gln Cys Pro Gly Cys 
            180                 185                 190         


Thr Phe Ile Asn Lys Pro Thr Arg Pro Gly Cys Glu Met Cys Cys Arg 
        195                 200                 205             


Ala Arg Pro Glu Ala Tyr Gln Val Pro Ala Ser Tyr Gln Pro Asp Glu 
    210                 215                 220                 


Glu Glu Arg Ala Arg Leu Ala Gly Glu Glu Glu Ala Leu Arg Gln Tyr 
225                 230                 235                 240 


Gln Gln Arg Lys Gln Gln Gln Gln Glu Gly Asn Tyr Leu Gln His Val 
                245                 250                 255     


Gln Leu Asp Gln Arg Ser Leu Val Leu Asn Thr Glu Pro Ala Glu Cys 
            260                 265                 270         


Pro Val Cys Tyr Ser Val Leu Ala Pro Gly Glu Ala Val Val Leu Arg 
        275                 280                 285             


Glu Cys Leu His Thr Phe Cys Arg Glu Cys Leu Gln Gly Thr Ile Arg 
    290                 295                 300                 


Asn Ser Gln Glu Ala Glu Val Ser Cys Pro Phe Ile Asp Asn Thr Tyr 
305                 310                 315                 320 


Ser Cys Ser Gly Lys Leu Leu Glu Arg Glu Ile Lys Ala Leu Leu Thr 
                325                 330                 335     


Pro Glu Asp Tyr Gln Arg Phe Leu Asp Leu Gly Ile Ser Ile Ala Glu 
            340                 345                 350         


Asn Arg Ser Ala Phe Ser Tyr His Cys Lys Thr Pro Asp Cys Lys Gly 
        355                 360                 365             


Trp Cys Phe Phe Glu Asp Asp Val Asn Glu Phe Thr Cys Pro Val Cys 
    370                 375                 380                 


Phe His Val Asn Cys Leu Leu Cys Lys Ala Ile His Glu Gln Met Asn 
385                 390                 395                 400 


Cys Lys Glu Tyr Gln Glu Asp Leu Ala Leu Arg Ala Gln Asn Asp Val 
                405                 410                 415     


Ala Ala Arg Gln Thr Thr Glu Met Leu Lys Val Met Leu Gln Gln Gly 
            420                 425                 430         


Glu Ala Met Arg Cys Pro Gln Cys Gln Ile Val Val Gln Lys Lys Asp 
        435                 440                 445             


Gly Cys Asp Trp Ile Arg Cys Thr Val Cys His Thr Glu Ile Cys Trp 
    450                 455                 460                 


Val Thr Lys Gly Pro Arg Trp Gly Pro Gly Gly Pro Gly Asp Thr Ser 
465                 470                 475                 480 


Gly Gly Cys Arg Cys Arg Val Asn Gly Ile Pro Cys His Pro Ser Cys 
                485                 490                 495     


Gln Asn Cys His 
            500 


<210>  3806
<211>  2020
<212>  DNA
<213>  Homosapiens

<400>  3806
ccgatgccga gcgggtgcta cgtcccgcgg tcggagccgc gtcttctccc ggctccgcca     60

ccagccgggg ctcgggtggg ggcccggggc cccggggcat ggccctccgg agtgcgcagg    120

gcgacggccc cacctccggc cactgggacg gcggcgcgga gaaggcagac tttaacgcca    180

aaaggaaaaa gaaagtggca gagatacacc aggctctgaa cagtgatccc actgatgtgg    240

ctgcccttag acgcatggct atcagtgaag gagggctcct gactgatgag atcagacgaa    300

aagtgtggcc caagctcctc aatgtcaatg ccaatgaccc acctcctata tcagggaaga    360

acctacggca gatgagcaag gactaccaac aagtgttgct ggacgtccgg cggtcattgc    420

ggcggttccc tcctggcatg ccagaggaac agagagaagg gctccaggaa gaactgattg    480

acatcatcct cctcatcttg gagcgcaacc ctcagctgca ctactaccag ggctaccatg    540

acattgtggt cacatttctg ctggtggtag gcgagaggct ggcaacatcc ctggtagaaa    600

aattatctac ccaccacctc agggatttta tggatccaac aatggacaac accaagcata    660

tattaaacta tctgatgccc atcattgacc aggtgaatcc agagctccat gacttcatgc    720

agagtgctga ggtagggacc atctttgccc tcagctggct catcacctgg tttgggcatg    780

tcctgtctga cttcaggcac gtcgtgcggt tatatgactt cttcctggcc tgccacccac    840

tgatgccgat ttactttgca gccgtgattg tgttgtatcg cgagcaggaa gtcctggact    900

gtgactgtga catggcctcg gtccaccacc tgttgtccca gatccctcag gacttgccct    960

atgagacact gatcagcaga gcaggagacc tttttgttca gtttccccca tccgaacttg   1020

ctcgggaggc cgctgcccaa cagcaagctg agaggacggc agcctctact ttcaaagact   1080

ttgagctggc atcagcccag cagaggcctg atatggtgct gcggcagcgg tttcggggac   1140

ttctgcggcc tgaagatcga acaaaagatg tcctgaccaa gccaaggacc aaccgctttg   1200

tgaaattggc agtgatgggg ctgacagtgg cacttggagc ggctgcactg gctgtggtga   1260

aaagtgccct ggaatgggcc cctaagtttc agctgcagct gtttccctga aagccagaga   1320

agaccttcct cttacatcac attaaggcac ccactcacta ccttggcgtc gttttttggg   1380

tctgacttga ctcgtcaact gctggtctct cccacctggt tggaaatgtc gttggaaact   1440

tgcaaagact ctccagacct tagggaacaa gaggcatcac tcagtccttc tgggacagct   1500

tccctgcctc agaaaacgga atctctgtct gtgaccttct cctgccccat ttcacttgct   1560

caacaccaga ctttaatctg actgtagctc ataagaccct cattccagag agggtgctgc   1620

cccatacccg gaaggaggaa cgctgcacag agaggccaag aagcatctgg acagacaggc   1680

cttgctgggt ttagacctta tgctttttgt ccagtttcat ctcaacacag ctgccatgct   1740

tcagccatgc ctatccaatg acgtctccat aaaaggccca ggaacacggg agcttctgaa   1800

gagctgaaca tgtggaggga ggggaacgag aacttgtcca tgtgccaaga gggtggcgca   1860

cccccactcc atggggacag aagctccagc atttgcccag gacccgtcca gacctcaccc   1920

tgtgtgtatc ttcatctggc tgtttactta tttgtatcct tttctaataa tgtttgtaat   1980

aaactggtaa acataaaaaa aaaaaaaaaa aaaaaaaaaa                         2020


<210>  3807
<211>  403
<212>  PRT
<213>  Homosapiens

<400>  3807

Met Ala Leu Arg Ser Ala Gln Gly Asp Gly Pro Thr Ser Gly His Trp 
1               5                   10                  15      


Asp Gly Gly Ala Glu Lys Ala Asp Phe Asn Ala Lys Arg Lys Lys Lys 
            20                  25                  30          


Val Ala Glu Ile His Gln Ala Leu Asn Ser Asp Pro Thr Asp Val Ala 
        35                  40                  45              


Ala Leu Arg Arg Met Ala Ile Ser Glu Gly Gly Leu Leu Thr Asp Glu 
    50                  55                  60                  


Ile Arg Arg Lys Val Trp Pro Lys Leu Leu Asn Val Asn Ala Asn Asp 
65                  70                  75                  80  


Pro Pro Pro Ile Ser Gly Lys Asn Leu Arg Gln Met Ser Lys Asp Tyr 
                85                  90                  95      


Gln Gln Val Leu Leu Asp Val Arg Arg Ser Leu Arg Arg Phe Pro Pro 
            100                 105                 110         


Gly Met Pro Glu Glu Gln Arg Glu Gly Leu Gln Glu Glu Leu Ile Asp 
        115                 120                 125             


Ile Ile Leu Leu Ile Leu Glu Arg Asn Pro Gln Leu His Tyr Tyr Gln 
    130                 135                 140                 


Gly Tyr His Asp Ile Val Val Thr Phe Leu Leu Val Val Gly Glu Arg 
145                 150                 155                 160 


Leu Ala Thr Ser Leu Val Glu Lys Leu Ser Thr His His Leu Arg Asp 
                165                 170                 175     


Phe Met Asp Pro Thr Met Asp Asn Thr Lys His Ile Leu Asn Tyr Leu 
            180                 185                 190         


Met Pro Ile Ile Asp Gln Val Asn Pro Glu Leu His Asp Phe Met Gln 
        195                 200                 205             


Ser Ala Glu Val Gly Thr Ile Phe Ala Leu Ser Trp Leu Ile Thr Trp 
    210                 215                 220                 


Phe Gly His Val Leu Ser Asp Phe Arg His Val Val Arg Leu Tyr Asp 
225                 230                 235                 240 


Phe Phe Leu Ala Cys His Pro Leu Met Pro Ile Tyr Phe Ala Ala Val 
                245                 250                 255     


Ile Val Leu Tyr Arg Glu Gln Glu Val Leu Asp Cys Asp Cys Asp Met 
            260                 265                 270         


Ala Ser Val His His Leu Leu Ser Gln Ile Pro Gln Asp Leu Pro Tyr 
        275                 280                 285             


Glu Thr Leu Ile Ser Arg Ala Gly Asp Leu Phe Val Gln Phe Pro Pro 
    290                 295                 300                 


Ser Glu Leu Ala Arg Glu Ala Ala Ala Gln Gln Gln Ala Glu Arg Thr 
305                 310                 315                 320 


Ala Ala Ser Thr Phe Lys Asp Phe Glu Leu Ala Ser Ala Gln Gln Arg 
                325                 330                 335     


Pro Asp Met Val Leu Arg Gln Arg Phe Arg Gly Leu Leu Arg Pro Glu 
            340                 345                 350         


Asp Arg Thr Lys Asp Val Leu Thr Lys Pro Arg Thr Asn Arg Phe Val 
        355                 360                 365             


Lys Leu Ala Val Met Gly Leu Thr Val Ala Leu Gly Ala Ala Ala Leu 
    370                 375                 380                 


Ala Val Val Lys Ser Ala Leu Glu Trp Ala Pro Lys Phe Gln Leu Gln 
385                 390                 395                 400 


Leu Phe Pro 
            


<210>  3808
<211>  2732
<212>  DNA
<213>  Homosapiens

<400>  3808
cccgcctcct ggtaggaggg ggtttccgct tccggcagca gcggctgcag cctcgctctg     60

gtccctgcgg ctggcggccg agccgtgtgt ctcctcctcc atcgccgcca tattgtctgt    120

gtgagcagag gggagagcgg ccgccgccgc tgccgcttcc accacagttt gaagaaaaca    180

ggtctgaaac aaggtcttac ccccagctgc ttctgaacac agtgactgcc agatctccaa    240

acatcaagtc cagctttgtc cgccaacctg tctgacatgt cgggacccgt gccaagcagg    300

gccagagttt acacagatgt taatacacac agacctcgag aatactggga ttacgagtca    360

catgtggtgg aatggggaaa tcaagatgac taccagctgg ttcgaaaatt aggccgaggt    420

aaatacagtg aagtatttga agccatcaac atcacaaata atgaaaaagt tgttgttaaa    480

attctcaagc cagtaaaaaa gaagaaaatt aagcgtgaaa taaagatttt ggagaatttg    540

agaggaggtc ccaacatcat cacactggca gacattgtaa aagaccctgt gtcacgaacc    600

cccgccttgg tttttgaaca cgtaaacaac acagacttca agcaattgta ccagacgtta    660

acagactatg atattcgatt ttacatgtat gagattctga aggccctgga ttattgtcac    720

agcatgggaa ttatgcacag agatgtcaag ccccataatg tcatgattga tcatgagcac    780

agaaagctac gactaataga ctggggtttg gctgagtttt atcatcctgg ccaagaatat    840

aatgtccgag ttgcttcccg atacttcaaa ggtcctgagc tacttgtaga ctatcagatg    900

tacgattata gtttggatat gtggagtttg ggttgtatgc tggcaagtat gatctttcgg    960

aaggagccat ttttccatgg acatgacaat tatgatcagt tggtgaggat agccaaggtt   1020

ctggggacag aagatttata tgactatatt gacaaataca acattgaatt agatccacgt   1080

ttcaatgata tcttgggcag acactctcga aagcgatggg aacgctttgt ccacagtgaa   1140

aatcagcacc ttgtcagccc tgaggccttg gatttcctgg acaaactgct gcgatatgac   1200

caccagtcac ggcttactgc aagagaggca atggagcacc cctatttcta cactgttgtg   1260

aaggaccagg ctcgaatggg ttcatctagc atgccagggg gcagtacgcc cgtcagcagc   1320

gccaatatga tgtcagggat ttcttcagtg ccaacccctt caccccttgg acctctggca   1380

ggctcaccag tgattgctgc tgccaacccc cttgggatgc ctgttccagc tgccgctggc   1440

gctcagcagt aacggcccta tctgtctcct gatgcctgag cagaggtggg ggagtccacc   1500

ctctccttga tgcagcttgc gcctggcggg gaggggtgaa acacttcaga agcaccgtgt   1560

ctgaaccgtt gcttgtggat ttatagtagt tcagtcataa aaaaaaaatt ataataggct   1620

gattttcttt tttctttttt tttttaactc gaacttttca taactcaggg gattccctga   1680

aaaattacct gcaggtggaa tatttcatgg acaaattttt ttttctcccc tcccaaattt   1740

agttcctcat cacaaaagaa caaagataaa ccagcctcaa tcccggctgc tgcatttagg   1800

tggagacttc ttcccattcc caccattgtt cctccaccgt cccacacttt agggggttgg   1860

tatctcgtgc tcttctccag agattacaaa aatgtagctt ctcaggggag gcaggaagaa   1920

aggaaggaag gaaagaagga agggaggacc caatctatag gagcagtgga ctgcttgctg   1980

gtcgcttaca tcactttact ccataagcgc ttcagtgggg ttatcctagt ggctcttgtg   2040

gaagtgtgtc ttagttacat caagatgttg aaaatctacc caaaatgcag acagatacta   2100

aaaacttctg ttcagtaaga atcatgtctt actgatctaa ccctaaatcc aactcattta   2160

tacttttatt tttagttcag tttaaaatgt tgataccttc cctcccaggc tccttacctt   2220

ggtcttttcc ctgttcatct cccaacatgc tgtgctccat agctggtagg agagggaagg   2280

caaaatcttt cttagttttc tttgtcttgg ccattttgaa ttcatttagt tactgggcat   2340

aacttactgc tttttacaaa agaaacaaac attgtctgta caggtttcat gctagagcta   2400

atgggagatg tggccacact gacttccatt ttaagctttc taccttcttt tcctccgacc   2460

gtccccttcc ctcacatgcc atccagtgag aagacctgct cctcagtctt gtaaatgtat   2520

cttgagaggt aggagcagag ccactatctc cattgaagct gaaatggtag acctgtaatt   2580

gtgggaaaac tataaactct cttgttacag ccccgccacc ccttgctgtg tgtatatata   2640

taatactttg tccttcatat gtgaaagatc cagtgttgga attctttggt gtaaataaac   2700

gtttggtttt atttatcaaa aaaaaaaaaa aa                                 2732


<210>  3809
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  3809

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp 
                165                 170                 175     


Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val 
            180                 185                 190         


Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met 
        195                 200                 205             


Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser 
    210                 215                 220                 


Met Ile Phe Arg Lys Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp 
225                 230                 235                 240 


Gln Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu Asp Leu Tyr Asp 
                245                 250                 255     


Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile 
            260                 265                 270         


Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu 
        275                 280                 285             


Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu 
    290                 295                 300                 


Leu Arg Tyr Asp His Gln Ser Arg Leu Thr Ala Arg Glu Ala Met Glu 
305                 310                 315                 320 


His Pro Tyr Phe Tyr Thr Val Val Lys Asp Gln Ala Arg Met Gly Ser 
                325                 330                 335     


Ser Ser Met Pro Gly Gly Ser Thr Pro Val Ser Ser Ala Asn Met Met 
            340                 345                 350         


Ser Gly Ile Ser Ser Val Pro Thr Pro Ser Pro Leu Gly Pro Leu Ala 
        355                 360                 365             


Gly Ser Pro Val Ile Ala Ala Ala Asn Pro Leu Gly Met Pro Val Pro 
    370                 375                 380                 


Ala Ala Ala Gly Ala Gln Gln 
385                 390     


<210>  3810
<211>  2849
<212>  DNA
<213>  Homosapiens

<400>  3810
cccgcctcct ggtaggaggg ggtttccgct tccggcagca gcggctgcag cctcgctctg     60

gtccctgcgg ctggcggccg agccgtgtgt ctcctcctcc atcgccgcca tattgtctgt    120

gtgagcagag gggagagcgg ccgccgccgc tgccgcttcc accacagctc tatcaaggct    180

tgtcaagcag tgtgctcatc acatggtaaa tcatgcagcg tggaacctca taaaatctcc    240

aagaaacatc attcacccat actgactagt ttcacatctc tttgtttgaa gaaaacaggt    300

ctgaaacaag gtcttacccc cagctgcttc tgaacacagt gactgccaga tctccaaaca    360

tcaagtccag ctttgtccgc caacctgtct gacatgtcgg gacccgtgcc aagcagggcc    420

agagtttaca cagatgttaa tacacacaga cctcgagaat actgggatta cgagtcacat    480

gtggtggaat ggggaaatca agatgactac cagctggttc gaaaattagg ccgaggtaaa    540

tacagtgaag tatttgaagc catcaacatc acaaataatg aaaaagttgt tgttaaaatt    600

ctcaagccag taaaaaagaa gaaaattaag cgtgaaataa agattttgga gaatttgaga    660

ggaggtccca acatcatcac actggcagac attgtaaaag accctgtgtc acgaaccccc    720

gccttggttt ttgaacacgt aaacaacaca gacttcaagc aattgtacca gacgttaaca    780

gactatgata ttcgatttta catgtatgag attctgaagg ccctggatta ttgtcacagc    840

atgggaatta tgcacagaga tgtcaagccc cataatgtca tgattgatca tgagcacaga    900

aagctacgac taatagactg gggtttggct gagttttatc atcctggcca agaatataat    960

gtccgagttg cttcccgata cttcaaaggt cctgagctac ttgtagacta tcagatgtac   1020

gattatagtt tggatatgtg gagtttgggt tgtatgctgg caagtatgat ctttcggaag   1080

gagccatttt tccatggaca tgacaattat gatcagttgg tgaggatagc caaggttctg   1140

gggacagaag atttatatga ctatattgac aaatacaaca ttgaattaga tccacgtttc   1200

aatgatatct tgggcagaca ctctcgaaag cgatgggaac gctttgtcca cagtgaaaat   1260

cagcaccttg tcagccctga ggccttggat ttcctggaca aactgctgcg atatgaccac   1320

cagtcacggc ttactgcaag agaggcaatg gagcacccct atttctacac tgttgtgaag   1380

gaccaggctc gaatgggttc atctagcatg ccagggggca gtacgcccgt cagcagcgcc   1440

aatatgatgt cagggatttc ttcagtgcca accccttcac cccttggacc tctggcaggc   1500

tcaccagtga ttgctgctgc caaccccctt gggatgcctg ttccagctgc cgctggcgct   1560

cagcagtaac ggccctatct gtctcctgat gcctgagcag aggtggggga gtccaccctc   1620

tccttgatgc agcttgcgcc tggcggggag gggtgaaaca cttcagaagc accgtgtctg   1680

aaccgttgct tgtggattta tagtagttca gtcataaaaa aaaaattata ataggctgat   1740

tttctttttt cttttttttt ttaactcgaa cttttcataa ctcaggggat tccctgaaaa   1800

attacctgca ggtggaatat ttcatggaca aatttttttt tctcccctcc caaatttagt   1860

tcctcatcac aaaagaacaa agataaacca gcctcaatcc cggctgctgc atttaggtgg   1920

agacttcttc ccattcccac cattgttcct ccaccgtccc acactttagg gggttggtat   1980

ctcgtgctct tctccagaga ttacaaaaat gtagcttctc aggggaggca ggaagaaagg   2040

aaggaaggaa agaaggaagg gaggacccaa tctataggag cagtggactg cttgctggtc   2100

gcttacatca ctttactcca taagcgcttc agtggggtta tcctagtggc tcttgtggaa   2160

gtgtgtctta gttacatcaa gatgttgaaa atctacccaa aatgcagaca gatactaaaa   2220

acttctgttc agtaagaatc atgtcttact gatctaaccc taaatccaac tcatttatac   2280

ttttattttt agttcagttt aaaatgttga taccttccct cccaggctcc ttaccttggt   2340

cttttccctg ttcatctccc aacatgctgt gctccatagc tggtaggaga gggaaggcaa   2400

aatctttctt agttttcttt gtcttggcca ttttgaattc atttagttac tgggcataac   2460

ttactgcttt ttacaaaaga aacaaacatt gtctgtacag gtttcatgct agagctaatg   2520

ggagatgtgg ccacactgac ttccatttta agctttctac cttcttttcc tccgaccgtc   2580

cccttccctc acatgccatc cagtgagaag acctgctcct cagtcttgta aatgtatctt   2640

gagaggtagg agcagagcca ctatctccat tgaagctgaa atggtagacc tgtaattgtg   2700

ggaaaactat aaactctctt gttacagccc cgccacccct tgctgtgtgt atatatataa   2760

tactttgtcc ttcatatgtg aaagatccag tgttggaatt ctttggtgta aataaacgtt   2820

tggttttatt tatcaaaaaa aaaaaaaaa                                     2849


<210>  3811
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  3811

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp 
                165                 170                 175     


Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val 
            180                 185                 190         


Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met 
        195                 200                 205             


Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser 
    210                 215                 220                 


Met Ile Phe Arg Lys Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp 
225                 230                 235                 240 


Gln Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu Asp Leu Tyr Asp 
                245                 250                 255     


Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile 
            260                 265                 270         


Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu 
        275                 280                 285             


Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu 
    290                 295                 300                 


Leu Arg Tyr Asp His Gln Ser Arg Leu Thr Ala Arg Glu Ala Met Glu 
305                 310                 315                 320 


His Pro Tyr Phe Tyr Thr Val Val Lys Asp Gln Ala Arg Met Gly Ser 
                325                 330                 335     


Ser Ser Met Pro Gly Gly Ser Thr Pro Val Ser Ser Ala Asn Met Met 
            340                 345                 350         


Ser Gly Ile Ser Ser Val Pro Thr Pro Ser Pro Leu Gly Pro Leu Ala 
        355                 360                 365             


Gly Ser Pro Val Ile Ala Ala Ala Asn Pro Leu Gly Met Pro Val Pro 
    370                 375                 380                 


Ala Ala Ala Gly Ala Gln Gln 
385                 390     


<210>  3812
<211>  2522
<212>  DNA
<213>  Homosapiens

<400>  3812
cccgcctcct ggtaggaggg ggtttccgct tccggcagca gcggctgcag cctcgctctg     60

gtccctgcgg ctggcggccg agccgtgtgt ctcctcctcc atcgccgcca tattgtctgt    120

gtgagcagag gggagagcgg ccgccgccgc tgccgcttcc accacagaaa tcaagatgac    180

taccagctgg ttcgaaaatt aggccgaggt aaatacagtg aagtatttga agccatcaac    240

atcacaaata atgaaaaagt tgttgttaaa attctcaagc cagtaaaaaa gaagaaaatt    300

aagcgtgaaa taaagatttt ggagaatttg agaggaggtc ccaacatcat cacactggca    360

gacattgtaa aagaccctgt gtcacgaacc cccgccttgg tttttgaaca cgtaaacaac    420

acagacttca agcaattgta ccagacgtta acagactatg atattcgatt ttacatgtat    480

gagattctga aggccctgga ttattgtcac agcatgggaa ttatgcacag agatgtcaag    540

ccccataatg tcatgattga tcatgagcac agaaagctac gactaataga ctggggtttg    600

gctgagtttt atcatcctgg ccaagaatat aatgtccgag ttgcttcccg atacttcaaa    660

ggtcctgagc tacttgtaga ctatcagatg tacgattata gtttggatat gtggagtttg    720

ggttgtatgc tggcaagtat gatctttcgg aaggagccat ttttccatgg acatgacaat    780

tatgatcagt tggtgaggat agccaaggtt ctggggacag aagatttata tgactatatt    840

gacaaataca acattgaatt agatccacgt ttcaatgata tcttgggcag acactctcga    900

aagcgatggg aacgctttgt ccacagtgaa aatcagcacc ttgtcagccc tgaggccttg    960

gatttcctgg acaaactgct gcgatatgac caccagtcac ggcttactgc aagagaggca   1020

atggagcacc cctatttcta cactgttgtg aaggaccagg ctcgaatggg ttcatctagc   1080

atgccagggg gcagtacgcc cgtcagcagc gccaatatga tgtcagggat ttcttcagtg   1140

ccaacccctt caccccttgg acctctggca ggctcaccag tgattgctgc tgccaacccc   1200

cttgggatgc ctgttccagc tgccgctggc gctcagcagt aacggcccta tctgtctcct   1260

gatgcctgag cagaggtggg ggagtccacc ctctccttga tgcagcttgc gcctggcggg   1320

gaggggtgaa acacttcaga agcaccgtgt ctgaaccgtt gcttgtggat ttatagtagt   1380

tcagtcataa aaaaaaaatt ataataggct gattttcttt tttctttttt tttttaactc   1440

gaacttttca taactcaggg gattccctga aaaattacct gcaggtggaa tatttcatgg   1500

acaaattttt ttttctcccc tcccaaattt agttcctcat cacaaaagaa caaagataaa   1560

ccagcctcaa tcccggctgc tgcatttagg tggagacttc ttcccattcc caccattgtt   1620

cctccaccgt cccacacttt agggggttgg tatctcgtgc tcttctccag agattacaaa   1680

aatgtagctt ctcaggggag gcaggaagaa aggaaggaag gaaagaagga agggaggacc   1740

caatctatag gagcagtgga ctgcttgctg gtcgcttaca tcactttact ccataagcgc   1800

ttcagtgggg ttatcctagt ggctcttgtg gaagtgtgtc ttagttacat caagatgttg   1860

aaaatctacc caaaatgcag acagatacta aaaacttctg ttcagtaaga atcatgtctt   1920

actgatctaa ccctaaatcc aactcattta tacttttatt tttagttcag tttaaaatgt   1980

tgataccttc cctcccaggc tccttacctt ggtcttttcc ctgttcatct cccaacatgc   2040

tgtgctccat agctggtagg agagggaagg caaaatcttt cttagttttc tttgtcttgg   2100

ccattttgaa ttcatttagt tactgggcat aacttactgc tttttacaaa agaaacaaac   2160

attgtctgta caggtttcat gctagagcta atgggagatg tggccacact gacttccatt   2220

ttaagctttc taccttcttt tcctccgacc gtccccttcc ctcacatgcc atccagtgag   2280

aagacctgct cctcagtctt gtaaatgtat cttgagaggt aggagcagag ccactatctc   2340

cattgaagct gaaatggtag acctgtaatt gtgggaaaac tataaactct cttgttacag   2400

ccccgccacc ccttgctgtg tgtatatata taatactttg tccttcatat gtgaaagatc   2460

cagtgttgga attctttggt gtaaataaac gtttggtttt atttatcaaa aaaaaaaaaa   2520

aa                                                                  2522


<210>  3813
<211>  255
<212>  PRT
<213>  Homosapiens

<400>  3813

Met Tyr Glu Ile Leu Lys Ala Leu Asp Tyr Cys His Ser Met Gly Ile 
1               5                   10                  15      


Met His Arg Asp Val Lys Pro His Asn Val Met Ile Asp His Glu His 
            20                  25                  30          


Arg Lys Leu Arg Leu Ile Asp Trp Gly Leu Ala Glu Phe Tyr His Pro 
        35                  40                  45              


Gly Gln Glu Tyr Asn Val Arg Val Ala Ser Arg Tyr Phe Lys Gly Pro 
    50                  55                  60                  


Glu Leu Leu Val Asp Tyr Gln Met Tyr Asp Tyr Ser Leu Asp Met Trp 
65                  70                  75                  80  


Ser Leu Gly Cys Met Leu Ala Ser Met Ile Phe Arg Lys Glu Pro Phe 
                85                  90                  95      


Phe His Gly His Asp Asn Tyr Asp Gln Leu Val Arg Ile Ala Lys Val 
            100                 105                 110         


Leu Gly Thr Glu Asp Leu Tyr Asp Tyr Ile Asp Lys Tyr Asn Ile Glu 
        115                 120                 125             


Leu Asp Pro Arg Phe Asn Asp Ile Leu Gly Arg His Ser Arg Lys Arg 
    130                 135                 140                 


Trp Glu Arg Phe Val His Ser Glu Asn Gln His Leu Val Ser Pro Glu 
145                 150                 155                 160 


Ala Leu Asp Phe Leu Asp Lys Leu Leu Arg Tyr Asp His Gln Ser Arg 
                165                 170                 175     


Leu Thr Ala Arg Glu Ala Met Glu His Pro Tyr Phe Tyr Thr Val Val 
            180                 185                 190         


Lys Asp Gln Ala Arg Met Gly Ser Ser Ser Met Pro Gly Gly Ser Thr 
        195                 200                 205             


Pro Val Ser Ser Ala Asn Met Met Ser Gly Ile Ser Ser Val Pro Thr 
    210                 215                 220                 


Pro Ser Pro Leu Gly Pro Leu Ala Gly Ser Pro Val Ile Ala Ala Ala 
225                 230                 235                 240 


Asn Pro Leu Gly Met Pro Val Pro Ala Ala Ala Gly Ala Gln Gln 
                245                 250                 255 


<210>  3814
<211>  2722
<212>  DNA
<213>  Homosapiens

<400>  3814
cacagcagcc cccgcgcccg ccgtgccgcc gccgggacgt ggggcccttg ggccgtcggg     60

ccgcctgggg agcgccagcc cggatccggc tgcccagatg cgggcgccac tctgcctgct    120

cctgctcgtc gcccacgccg tggacatgct cgccctgaac cgaaggaaga agcaagtggg    180

cactggcctg gggggcaact gcacaggctg tatcatctgc tcagaggaga acggctgttc    240

cacctgccag cagaggctct tcctgttcat ccgccgggaa ggcatccgcc agtacggcaa    300

gtgcctgcac gactgtcccc ctgggtactt cggcatccgc ggccaggagg tcaacaggtg    360

caaaaaatgt ggggccactt gtgagagctg cttcagccag gacttctgca tccggtgcaa    420

gaggcagttt tacttgtaca aggggaagtg tctgcccacc tgcccgccgg gcactttggc    480

ccaccagaac acacgggagt gccaggggga gtgtgaactg ggtccctggg gcggctggag    540

cccctgcaca cacaatggaa agacctgcgg ctcggcttgg ggcctggaga gccgggtacg    600

agaggctggc cgggctgggc atgaggaggc agccacctgc caggtgcttt ctgagtcaag    660

gaaatgtccc atccagaggc cctgcccagg agagaggagc cccggccaga agaagggcag    720

gaaggaccgg cgcccacgca aggacaggaa gctggaccgc aggctggacg tgaggccgcg    780

ccagcccggc ctgcagccct gaccgccggc tctcccgact ctctggtcct agtcctcggc    840

ccctgcacac ctcctcctgc tccttctcct cctctcctct tactctttct cctctgtctt    900

ctccatttgt cctctctttc tttccaccct tctatcattt ttctgtcagt ctaccttccc    960

tttctttttc ttttttattt cctttatttc ttccacctcc attctcctct cctttctccc   1020

tccctccttc ccttccttcc tcttctttct cacttatctt ttatctttcc ttttctttct   1080

tcctgtgttt cttcctgtcc ttcaccgcat ccttctctct ctccctcctc ttgtctccct   1140

ctcacacaca ctttaagagg gaccatgagc ctgtgccctc ccctgcagct ttctctatct   1200

acaacttaaa gaaagcaaac atcttttccc aggcctttcc ctgaccccat ctttgcagag   1260

aaagggtttc cagagggcaa agctgggaca cagcacaggt gaatcctgaa ggccctgctt   1320

ctgctctggg ggaggctcca ggaccctgag ctgtgagcac ctggttctct ggacagtccc   1380

cagaggccat ttccacagcc ttcagccacc agccaccccg aggagctggc tggacaaggc   1440

tccagggctt ccagaggcct ggcttggaca cctcccccag ctggccgtgg agggtcacaa   1500

cctggcctct gggtgggcag ccagccctgg agggcatcct ctgcaagctg cctgccaccc   1560

tcatcggcac tcccccacag gcctccctct catgggttcc atgccccttt ttcccaagcc   1620

ggatcaggtg agctgtcact gctgggggat ccacctgccc agcccagaag aggccactga   1680

aacggaaagg aaagctgaga ttatccagca gctctgttcc ccacctcagc gcttcctgcc   1740

catgtgggga aacaggtctg agaaggaagg ggcttgccca gggtcacaca ggaagccttc   1800

aggctctgct tctgcctgat ggctctgctc agcacattca cggtggagag gagaatttgg   1860

gggtcacttg aggggggaaa tgtagggaat tgtgggtggg gagcaaggga agatccgtgc   1920

actcgtccac acccaccacc acactcgctg acacccaccc ccacacgctg acacccaccc   1980

ccacacttgc ccacacccat caccgcactc gcccacaccc accaccacac tgccccacac   2040

ccaccaccac actcccccac acccaccacc acactcgccc acacccacca ccagtgactt   2100

gagcatctgt gcttcgctgt gacgcccctc gccctaggca ggaacgacgc tgggaggagt   2160

ctccaggtca gacccagctt ggaagcaagt ctgtcctcac tgcctatcct tctgccatca   2220

taacaccccc ttcctgctct gctccccgga atcctcagaa acgggatttg tatttgccgt   2280

gactggttgg cctgaacacg tagggctccg tgactgggac aggaatgggc aggagaagca   2340

agagtcggag ctccaagggg cccaggggtg gcctggggaa ggaagatggt cagcaggctg   2400

ggggagaggc tctaggtgat gaaatattac attcccgacc ccaagagagc acccaccctc   2460

agacctgccc tccacctggc agctggggag ccctggcctg aacccccccc tcccagcagg   2520

cccaccctct ctctgacttc cctgctctca cctccccgag aacagctaga gccccctcct   2580

ccgcctggcc aggccaccag cttctcttct gcaaacgttt gtgcctctga aatgctccgt   2640

tgttattgtt tcaagaccct aacttttttt taaaactttc ttaataaagg gaaaagaaac   2700

ttgtaaaaaa aaaaaaaaaa aa                                            2722


<210>  3815
<211>  234
<212>  PRT
<213>  Homosapiens

<400>  3815

Met Arg Ala Pro Leu Cys Leu Leu Leu Leu Val Ala His Ala Val Asp 
1               5                   10                  15      


Met Leu Ala Leu Asn Arg Arg Lys Lys Gln Val Gly Thr Gly Leu Gly 
            20                  25                  30          


Gly Asn Cys Thr Gly Cys Ile Ile Cys Ser Glu Glu Asn Gly Cys Ser 
        35                  40                  45              


Thr Cys Gln Gln Arg Leu Phe Leu Phe Ile Arg Arg Glu Gly Ile Arg 
    50                  55                  60                  


Gln Tyr Gly Lys Cys Leu His Asp Cys Pro Pro Gly Tyr Phe Gly Ile 
65                  70                  75                  80  


Arg Gly Gln Glu Val Asn Arg Cys Lys Lys Cys Gly Ala Thr Cys Glu 
                85                  90                  95      


Ser Cys Phe Ser Gln Asp Phe Cys Ile Arg Cys Lys Arg Gln Phe Tyr 
            100                 105                 110         


Leu Tyr Lys Gly Lys Cys Leu Pro Thr Cys Pro Pro Gly Thr Leu Ala 
        115                 120                 125             


His Gln Asn Thr Arg Glu Cys Gln Gly Glu Cys Glu Leu Gly Pro Trp 
    130                 135                 140                 


Gly Gly Trp Ser Pro Cys Thr His Asn Gly Lys Thr Cys Gly Ser Ala 
145                 150                 155                 160 


Trp Gly Leu Glu Ser Arg Val Arg Glu Ala Gly Arg Ala Gly His Glu 
                165                 170                 175     


Glu Ala Ala Thr Cys Gln Val Leu Ser Glu Ser Arg Lys Cys Pro Ile 
            180                 185                 190         


Gln Arg Pro Cys Pro Gly Glu Arg Ser Pro Gly Gln Lys Lys Gly Arg 
        195                 200                 205             


Lys Asp Arg Arg Pro Arg Lys Asp Arg Lys Leu Asp Arg Arg Leu Asp 
    210                 215                 220                 


Val Arg Pro Arg Gln Pro Gly Leu Gln Pro 
225                 230                 


<210>  3816
<211>  2536
<212>  DNA
<213>  Homosapiens

<400>  3816
cacagcagcc cccgcgcccg ccgtgccgcc gccgggacgt ggggcccttg ggccgtcggg     60

ccgcctgggg agcgccagcc cggatccggc tgcccagatg cgggcgccac tctgcctgct    120

cctgctcgtc gcccacgccg tggacatgct cgccctgaac cgaaggaaga agcaagtggg    180

cactggcctg gggggcaact gcacaggctg tatcatctgc tcagaggaga acggctgttc    240

cacctgccag cagaggctct tcctgttcat ccgccgggaa ggcatccgcc agtacggcaa    300

gtgcctgcac gactgtcccc ctgggtactt cggcatccgc ggccaggagg tcaacaggtg    360

caaaaaatgt ggggccactt gtgagagctg cttcagccag gacttctgca tccggtgcaa    420

gaggcagttt tacttgtaca aggggaagtg tctgcccacc tgcccgccgg gcactttggc    480

ccaccagaac acacgggagt gccaggagag gagccccggc cagaagaagg gcaggaagga    540

ccggcgccca cgcaaggaca ggaagctgga ccgcaggctg gacgtgaggc cgcgccagcc    600

cggcctgcag ccctgaccgc cggctctccc gactctctgg tcctagtcct cggcccctgc    660

acacctcctc ctgctccttc tcctcctctc ctcttactct ttctcctctg tcttctccat    720

ttgtcctctc tttctttcca cccttctatc atttttctgt cagtctacct tccctttctt    780

tttctttttt atttccttta tttcttccac ctccattctc ctctcctttc tccctccctc    840

cttcccttcc ttcctcttct ttctcactta tcttttatct ttccttttct ttcttcctgt    900

gtttcttcct gtccttcacc gcatccttct ctctctccct cctcttgtct ccctctcaca    960

cacactttaa gagggaccat gagcctgtgc cctcccctgc agctttctct atctacaact   1020

taaagaaagc aaacatcttt tcccaggcct ttccctgacc ccatctttgc agagaaaggg   1080

tttccagagg gcaaagctgg gacacagcac aggtgaatcc tgaaggccct gcttctgctc   1140

tgggggaggc tccaggaccc tgagctgtga gcacctggtt ctctggacag tccccagagg   1200

ccatttccac agccttcagc caccagccac cccgaggagc tggctggaca aggctccagg   1260

gcttccagag gcctggcttg gacacctccc ccagctggcc gtggagggtc acaacctggc   1320

ctctgggtgg gcagccagcc ctggagggca tcctctgcaa gctgcctgcc accctcatcg   1380

gcactccccc acaggcctcc ctctcatggg ttccatgccc ctttttccca agccggatca   1440

ggtgagctgt cactgctggg ggatccacct gcccagccca gaagaggcca ctgaaacgga   1500

aaggaaagct gagattatcc agcagctctg ttccccacct cagcgcttcc tgcccatgtg   1560

gggaaacagg tctgagaagg aaggggcttg cccagggtca cacaggaagc cttcaggctc   1620

tgcttctgcc tgatggctct gctcagcaca ttcacggtgg agaggagaat ttgggggtca   1680

cttgaggggg gaaatgtagg gaattgtggg tggggagcaa gggaagatcc gtgcactcgt   1740

ccacacccac caccacactc gctgacaccc acccccacac gctgacaccc acccccacac   1800

ttgcccacac ccatcaccgc actcgcccac acccaccacc acactgcccc acacccacca   1860

ccacactccc ccacacccac caccacactc gcccacaccc accaccagtg acttgagcat   1920

ctgtgcttcg ctgtgacgcc cctcgcccta ggcaggaacg acgctgggag gagtctccag   1980

gtcagaccca gcttggaagc aagtctgtcc tcactgccta tccttctgcc atcataacac   2040

ccccttcctg ctctgctccc cggaatcctc agaaacggga tttgtatttg ccgtgactgg   2100

ttggcctgaa cacgtagggc tccgtgactg ggacaggaat gggcaggaga agcaagagtc   2160

ggagctccaa ggggcccagg ggtggcctgg ggaaggaaga tggtcagcag gctgggggag   2220

aggctctagg tgatgaaata ttacattccc gaccccaaga gagcacccac cctcagacct   2280

gccctccacc tggcagctgg ggagccctgg cctgaacccc cccctcccag caggcccacc   2340

ctctctctga cttccctgct ctcacctccc cgagaacagc tagagccccc tcctccgcct   2400

ggccaggcca ccagcttctc ttctgcaaac gtttgtgcct ctgaaatgct ccgttgttat   2460

tgtttcaaga ccctaacttt tttttaaaac tttcttaata aagggaaaag aaacttgtaa   2520

aaaaaaaaaa aaaaaa                                                   2536


<210>  3817
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  3817

Met Arg Ala Pro Leu Cys Leu Leu Leu Leu Val Ala His Ala Val Asp 
1               5                   10                  15      


Met Leu Ala Leu Asn Arg Arg Lys Lys Gln Val Gly Thr Gly Leu Gly 
            20                  25                  30          


Gly Asn Cys Thr Gly Cys Ile Ile Cys Ser Glu Glu Asn Gly Cys Ser 
        35                  40                  45              


Thr Cys Gln Gln Arg Leu Phe Leu Phe Ile Arg Arg Glu Gly Ile Arg 
    50                  55                  60                  


Gln Tyr Gly Lys Cys Leu His Asp Cys Pro Pro Gly Tyr Phe Gly Ile 
65                  70                  75                  80  


Arg Gly Gln Glu Val Asn Arg Cys Lys Lys Cys Gly Ala Thr Cys Glu 
                85                  90                  95      


Ser Cys Phe Ser Gln Asp Phe Cys Ile Arg Cys Lys Arg Gln Phe Tyr 
            100                 105                 110         


Leu Tyr Lys Gly Lys Cys Leu Pro Thr Cys Pro Pro Gly Thr Leu Ala 
        115                 120                 125             


His Gln Asn Thr Arg Glu Cys Gln Glu Arg Ser Pro Gly Gln Lys Lys 
    130                 135                 140                 


Gly Arg Lys Asp Arg Arg Pro Arg Lys Asp Arg Lys Leu Asp Arg Arg 
145                 150                 155                 160 


Leu Asp Val Arg Pro Arg Gln Pro Gly Leu Gln Pro 
                165                 170         


<210>  3818
<211>  3241
<212>  DNA
<213>  Homosapiens

<400>  3818
ggcttccccg ccccgccccg tccccgggcg tctccatttt ggtctcaggt gtggactcgg     60

caagaaccag cgcaagaggg aagcggagtt atagctaccc cggccgcgga gccggctcac    120

tgcactaccc ccgccccctt ctttcctcca gacgccgaag tcgcgggcgc tcatggcggg    180

cctggaggta ctgttcgcat cggcagcgcc ggccatcacc tgcaggcagg acgcgctcgt    240

ctgcttcttg cattgggaag tggtgacaca cggttactgc ggcttgggtg tcggtgacca    300

gccgggtccc aatgataaga agtcagaact gctgccagct gggtggaaca acaataaaga    360

cctgtatgtc ctccggtatg agtataagga tgggtccaga aagctccttg tgaaagccat    420

caccgtggag agcagcatga tcctcaatgt gctggaatat ggctcacagc aagtggcaga    480

cttgaccctg aacttggatg attatatcga tgcagaacac ctgggtgact tccacaggac    540

ctacaagaac agtgaggagc ttcggtctcg tattgtgtct ggaatcatca cacctatcca    600

tgagcagtgg gaaaaggcta atgtaagcag tccccaccgg gagttccccc ctgctaccgc    660

cagagaggtg gacccactcc ggattcctcc acaccaccca cacaccagtc ggcagcctcc    720

ctggtgtgat cccctgggcc cgtttgttgt cgggggagaa gacttagacc cttttgggcc    780

tcggagaggt ggcatgattg tggatcccct gagatctggc ttcccaagag cacttattga    840

cccttcctca ggcctcccga accgacttcc tccaggcgct gtgcccccag gagctcgctt    900

tgaccccttt ggacccattg ggaccagccc acccggacct aacccagacc atctcccccc    960

gccgggctac gatgacatgt acctgtgaag gcctcaagaa tgtaacatcc caggcttccc   1020

tccattctcc tggagctgcc accgctgtcc ccatcagcaa ccatgttctt gcaggctggg   1080

ggcaagggat tctgctcatg tgtttgcaga ccggctggga tagcctcccc accccttatc   1140

agagccaaga cacctgctgc agctctccac ctagctgcag atagctccca aagagaaatc   1200

agtgtgtctc tttcaccatc agctcctccc ctttcaccac cagctcctct ccacttccca   1260

agggagactc cggcaacctt cagcaacata tatcctcgac cagatgcagt gctataagaa   1320

cagaacgcat tttggatgtt attattaaga accaaatgtc aatacagaat tcatgttgcc   1380

ggtttcccac ttttcttttt acattaatgc atagctgctt ccatttatga gactttagag   1440

tttgagtttc tgtagggctg aatgactctt tttcctgccc agggcccatt cttgcttctc   1500

aggcaccttc cgtttattaa ttgccattgc tcctgacatc actaagatgg gtccccttct   1560

ggctgcatga atggaaatga gtgactggaa atcccatagg ccacaagaat gactttcaca   1620

agggcaggaa cattgtggaa agactgcatc attctgatga ggcaaaatcc tccagctatt   1680

cctgtctggg ccagttttgt aggtccatct gtgcatgggc agcagtagtc aaaaagccaa   1740

ggaaaaaaca gagcagacct gaaggctaat cttatttttg ccactaactt agtgaatgac   1800

cctaagcaag ttccttctcc tcttagggcc ttgtgccaag cctatgaaat tggaggtggc   1860

tttcctgctc taaagcattt tgatgtctca ttctgtgttt ggtaacccct ataaactggg   1920

gcagaggaaa agaatgatgg ttcaaggcca tacttccctt gaaccttgtg tggttcttgc   1980

ctaactctgt ggtttttgga ccccatgggg cccagacaga gcacaggagc atgggctgcc   2040

tctgagtgtg gtgttgaact tcgggaggag cagggagccc tgcaccttgt gtcctggccc   2100

acctgacctt tggtgttctc cggatccttt tcagcccgag gcctgacaga cgcgggcagt   2160

gatgagccct gttctggagt ggaaagagca cgatagagca ccaggctaag aggcacgaga   2220

tcaaggcggt agtcacttcc gctctgcagc tagcatttca accatatgtg gatcctttca   2280

tttctcagct ccctggattc cttcccctaa attaggacct attatttacc tgtaggtaag   2340

caagctactg tagctcttct gaggtatctg ccaggctgtt ttctgtagcc tcagattgcc   2400

tatctgctta gcctgagaac aggtagatga aaactaaact gatgcctagg cccagggtca   2460

gtctcagatg gaagctgggc ctgggtgggg aggctagcat gcgtggctcc ctgggtattt   2520

ctgtcagtcc ccatggcaag cagtgattta gtaaaacacc ccagagtcag ggaagccaac   2580

caccttgaaa cctttagaac atctctgctt tggagaaaga cccagagatc aggcagaggt   2640

gcagattcaa tcattactca taacctttga gagctggcaa atgggaggag tgttagtctt   2700

tgttttggaa ttggaccatt cttgcaacca aaaggactta gagcagtttg ctcataaaga   2760

catcctttat tataaaagga agtatttaaa ggatgataga gaccatcaga tagaagcagg   2820

gaaggtagat aacttttagg accttgatgt gaggaaaaga taaaatttaa acaataaatt   2880

tgccacttag attttctagc agcaaagtcc gaaaagatag ttatatacaa aattctgttt   2940

tctgaaaaca aaattgtgat tcaccttcag aattggccat tttttttgtg agtttccttg   3000

catcaaggac actgagaaac acagtcattg tcttaggtgt tctatgggag gaagtgaata   3060

gagcctttag gaacttcctg gtcaagctta tggtgcttat tttgatctgg gccacttccc   3120

tccttccagt catgagtaat catcaaggag caagttggag tgtttcaggt gtatattttg   3180

tagaacccaa aagattggag ccttaacaat aaacatcagc actaagtgac ctgttaaaaa   3240

a                                                                   3241


<210>  3819
<211>  271
<212>  PRT
<213>  Homosapiens

<400>  3819

Met Ala Gly Leu Glu Val Leu Phe Ala Ser Ala Ala Pro Ala Ile Thr 
1               5                   10                  15      


Cys Arg Gln Asp Ala Leu Val Cys Phe Leu His Trp Glu Val Val Thr 
            20                  25                  30          


His Gly Tyr Cys Gly Leu Gly Val Gly Asp Gln Pro Gly Pro Asn Asp 
        35                  40                  45              


Lys Lys Ser Glu Leu Leu Pro Ala Gly Trp Asn Asn Asn Lys Asp Leu 
    50                  55                  60                  


Tyr Val Leu Arg Tyr Glu Tyr Lys Asp Gly Ser Arg Lys Leu Leu Val 
65                  70                  75                  80  


Lys Ala Ile Thr Val Glu Ser Ser Met Ile Leu Asn Val Leu Glu Tyr 
                85                  90                  95      


Gly Ser Gln Gln Val Ala Asp Leu Thr Leu Asn Leu Asp Asp Tyr Ile 
            100                 105                 110         


Asp Ala Glu His Leu Gly Asp Phe His Arg Thr Tyr Lys Asn Ser Glu 
        115                 120                 125             


Glu Leu Arg Ser Arg Ile Val Ser Gly Ile Ile Thr Pro Ile His Glu 
    130                 135                 140                 


Gln Trp Glu Lys Ala Asn Val Ser Ser Pro His Arg Glu Phe Pro Pro 
145                 150                 155                 160 


Ala Thr Ala Arg Glu Val Asp Pro Leu Arg Ile Pro Pro His His Pro 
                165                 170                 175     


His Thr Ser Arg Gln Pro Pro Trp Cys Asp Pro Leu Gly Pro Phe Val 
            180                 185                 190         


Val Gly Gly Glu Asp Leu Asp Pro Phe Gly Pro Arg Arg Gly Gly Met 
        195                 200                 205             


Ile Val Asp Pro Leu Arg Ser Gly Phe Pro Arg Ala Leu Ile Asp Pro 
    210                 215                 220                 


Ser Ser Gly Leu Pro Asn Arg Leu Pro Pro Gly Ala Val Pro Pro Gly 
225                 230                 235                 240 


Ala Arg Phe Asp Pro Phe Gly Pro Ile Gly Thr Ser Pro Pro Gly Pro 
                245                 250                 255     


Asn Pro Asp His Leu Pro Pro Pro Gly Tyr Asp Asp Met Tyr Leu 
            260                 265                 270     


<210>  3820
<211>  3204
<212>  DNA
<213>  Homosapiens

<400>  3820
ctctggcata ggctcttggt agtgggggcc cagacaggga ggcacctgcc acctgcttcc     60

cttctcagcc acccacagcc ctcatagggc agaatgggac tcttgctgat gtagacgccg    120

aagtcgcggg cgctcatggc gggcctggag gtactgttcg catcggcagc gccggccatc    180

acctgcaggc aggacgcgct cgtctgcttc ttgcattggg aagtggtgac acacggttac    240

tgcggcttgg gtgtcggtga ccagccgggt cccaatgata agaagtcaga actgctgcca    300

gctgggtgga acaacaataa agacctgtat gtcctccggt atgagtataa ggatgggtcc    360

agaaagctcc ttgtgaaagc catcaccgtg gagagcagca tgatcctcaa tgtgctggaa    420

tatggctcac agcaagtggc agacttgacc ctgaacttgg atgattatat cgatgcagaa    480

cacctgggtg acttccacag gacctacaag aacagtgagg agcttcggtc tcgtattgtg    540

tctggaatca tcacacctat ccatgagcag tgggaaaagg ctaatgtaag cagtccccac    600

cgggagttcc cccctgctac cgccagagag gtggacccac tccggattcc tccacaccac    660

ccacacacca gtcggcagcc tccctggtgt gatcccctgg gcccgtttgt tgtcggggga    720

gaagacttag acccttttgg gcctcggaga ggtggcatga ttgtggatcc cctgagatct    780

ggcttcccaa gagcacttat tgacccttcc tcaggcctcc cgaaccgact tcctccaggc    840

gctgtgcccc caggagctcg ctttgacccc tttggaccca ttgggaccag cccacccgga    900

cctaacccag accatctccc cccgccgggc tacgatgaca tgtacctgtg aaggcctcaa    960

gaatgtaaca tcccaggctt ccctccattc tcctggagct gccaccgctg tccccatcag   1020

caaccatgtt cttgcaggct gggggcaagg gattctgctc atgtgtttgc agaccggctg   1080

ggatagcctc cccacccctt atcagagcca agacacctgc tgcagctctc cacctagctg   1140

cagatagctc ccaaagagaa atcagtgtgt ctctttcacc atcagctcct cccctttcac   1200

caccagctcc tctccacttc ccaagggaga ctccggcaac cttcagcaac atatatcctc   1260

gaccagatgc agtgctataa gaacagaacg cattttggat gttattatta agaaccaaat   1320

gtcaatacag aattcatgtt gccggtttcc cacttttctt tttacattaa tgcatagctg   1380

cttccattta tgagacttta gagtttgagt ttctgtaggg ctgaatgact ctttttcctg   1440

cccagggccc attcttgctt ctcaggcacc ttccgtttat taattgccat tgctcctgac   1500

atcactaaga tgggtcccct tctggctgca tgaatggaaa tgagtgactg gaaatcccat   1560

aggccacaag aatgactttc acaagggcag gaacattgtg gaaagactgc atcattctga   1620

tgaggcaaaa tcctccagct attcctgtct gggccagttt tgtaggtcca tctgtgcatg   1680

ggcagcagta gtcaaaaagc caaggaaaaa acagagcaga cctgaaggct aatcttattt   1740

ttgccactaa cttagtgaat gaccctaagc aagttccttc tcctcttagg gccttgtgcc   1800

aagcctatga aattggaggt ggctttcctg ctctaaagca ttttgatgtc tcattctgtg   1860

tttggtaacc cctataaact ggggcagagg aaaagaatga tggttcaagg ccatacttcc   1920

cttgaacctt gtgtggttct tgcctaactc tgtggttttt ggaccccatg gggcccagac   1980

agagcacagg agcatgggct gcctctgagt gtggtgttga acttcgggag gagcagggag   2040

ccctgcacct tgtgtcctgg cccacctgac ctttggtgtt ctccggatcc ttttcagccc   2100

gaggcctgac agacgcgggc agtgatgagc cctgttctgg agtggaaaga gcacgataga   2160

gcaccaggct aagaggcacg agatcaaggc ggtagtcact tccgctctgc agctagcatt   2220

tcaaccatat gtggatcctt tcatttctca gctccctgga ttccttcccc taaattagga   2280

cctattattt acctgtaggt aagcaagcta ctgtagctct tctgaggtat ctgccaggct   2340

gttttctgta gcctcagatt gcctatctgc ttagcctgag aacaggtaga tgaaaactaa   2400

actgatgcct aggcccaggg tcagtctcag atggaagctg ggcctgggtg gggaggctag   2460

catgcgtggc tccctgggta tttctgtcag tccccatggc aagcagtgat ttagtaaaac   2520

accccagagt cagggaagcc aaccaccttg aaacctttag aacatctctg ctttggagaa   2580

agacccagag atcaggcaga ggtgcagatt caatcattac tcataacctt tgagagctgg   2640

caaatgggag gagtgttagt ctttgttttg gaattggacc attcttgcaa ccaaaaggac   2700

ttagagcagt ttgctcataa agacatcctt tattataaaa ggaagtattt aaaggatgat   2760

agagaccatc agatagaagc agggaaggta gataactttt aggaccttga tgtgaggaaa   2820

agataaaatt taaacaataa atttgccact tagattttct agcagcaaag tccgaaaaga   2880

tagttatata caaaattctg ttttctgaaa acaaaattgt gattcacctt cagaattggc   2940

catttttttt gtgagtttcc ttgcatcaag gacactgaga aacacagtca ttgtcttagg   3000

tgttctatgg gaggaagtga atagagcctt taggaacttc ctggtcaagc ttatggtgct   3060

tattttgatc tgggccactt ccctccttcc agtcatgagt aatcatcaag gagcaagttg   3120

gagtgtttca ggtgtatatt ttgtagaacc caaaagattg gagccttaac aataaacatc   3180

agcactaagt gacctgttaa aaaa                                          3204


<210>  3821
<211>  271
<212>  PRT
<213>  Homosapiens

<400>  3821

Met Ala Gly Leu Glu Val Leu Phe Ala Ser Ala Ala Pro Ala Ile Thr 
1               5                   10                  15      


Cys Arg Gln Asp Ala Leu Val Cys Phe Leu His Trp Glu Val Val Thr 
            20                  25                  30          


His Gly Tyr Cys Gly Leu Gly Val Gly Asp Gln Pro Gly Pro Asn Asp 
        35                  40                  45              


Lys Lys Ser Glu Leu Leu Pro Ala Gly Trp Asn Asn Asn Lys Asp Leu 
    50                  55                  60                  


Tyr Val Leu Arg Tyr Glu Tyr Lys Asp Gly Ser Arg Lys Leu Leu Val 
65                  70                  75                  80  


Lys Ala Ile Thr Val Glu Ser Ser Met Ile Leu Asn Val Leu Glu Tyr 
                85                  90                  95      


Gly Ser Gln Gln Val Ala Asp Leu Thr Leu Asn Leu Asp Asp Tyr Ile 
            100                 105                 110         


Asp Ala Glu His Leu Gly Asp Phe His Arg Thr Tyr Lys Asn Ser Glu 
        115                 120                 125             


Glu Leu Arg Ser Arg Ile Val Ser Gly Ile Ile Thr Pro Ile His Glu 
    130                 135                 140                 


Gln Trp Glu Lys Ala Asn Val Ser Ser Pro His Arg Glu Phe Pro Pro 
145                 150                 155                 160 


Ala Thr Ala Arg Glu Val Asp Pro Leu Arg Ile Pro Pro His His Pro 
                165                 170                 175     


His Thr Ser Arg Gln Pro Pro Trp Cys Asp Pro Leu Gly Pro Phe Val 
            180                 185                 190         


Val Gly Gly Glu Asp Leu Asp Pro Phe Gly Pro Arg Arg Gly Gly Met 
        195                 200                 205             


Ile Val Asp Pro Leu Arg Ser Gly Phe Pro Arg Ala Leu Ile Asp Pro 
    210                 215                 220                 


Ser Ser Gly Leu Pro Asn Arg Leu Pro Pro Gly Ala Val Pro Pro Gly 
225                 230                 235                 240 


Ala Arg Phe Asp Pro Phe Gly Pro Ile Gly Thr Ser Pro Pro Gly Pro 
                245                 250                 255     


Asn Pro Asp His Leu Pro Pro Pro Gly Tyr Asp Asp Met Tyr Leu 
            260                 265                 270     


<210>  3822
<211>  3158
<212>  DNA
<213>  Homosapiens

<400>  3822
ggcttccccg ccccgccccg tccccgggcg tctccatttt ggtctcaggt gtggactcgg     60

caagaaccag cgcaagaggg aagcggagtt atagctaccc cggccgcgga gccggctcac    120

tgcactaccc ccgccccctt ctttcctcca gacgccgaag tcgcgggcgc tcatggcggg    180

cctggaggta ctgttcgcat cggcagcgcc ggccatcacc tgcaggcagg acgcgctcgt    240

ctgcttcttg cattgggaag tggtgacaca cggttactgc ggcttgggtg tcggtgacca    300

gccgggtccc aatgataaga agtcagaact gctgccagct gggtggaaca acaataaaga    360

cctgtatgtc ctccggtatg agtataagga tgggtccaga aagctccttg tgaaagccat    420

caccgtggag agcagcatga tcctcaatgt gctggaccta caagaacagt gaggagcttc    480

ggtctcgtat tgtgtctgga atcatcacac ctatccatga gcagtgggaa aaggctaatg    540

taagcagtcc ccaccgggag ttcccccctg ctaccgccag agaggtggac ccactccgga    600

ttcctccaca ccacccacac accagtcggc agcctccctg gtgtgatccc ctgggcccgt    660

ttgttgtcgg gggagaagac ttagaccctt ttgggcctcg gagaggtggc atgattgtgg    720

atcccctgag atctggcttc ccaagagcac ttattgaccc ttcctcaggc ctcccgaacc    780

gacttcctcc aggcgctgtg cccccaggag ctcgctttga cccctttgga cccattggga    840

ccagcccacc cggacctaac ccagaccatc tccccccgcc gggctacgat gacatgtacc    900

tgtgaaggcc tcaagaatgt aacatcccag gcttccctcc attctcctgg agctgccacc    960

gctgtcccca tcagcaacca tgttcttgca ggctgggggc aagggattct gctcatgtgt   1020

ttgcagaccg gctgggatag cctccccacc ccttatcaga gccaagacac ctgctgcagc   1080

tctccaccta gctgcagata gctcccaaag agaaatcagt gtgtctcttt caccatcagc   1140

tcctcccctt tcaccaccag ctcctctcca cttcccaagg gagactccgg caaccttcag   1200

caacatatat cctcgaccag atgcagtgct ataagaacag aacgcatttt ggatgttatt   1260

attaagaacc aaatgtcaat acagaattca tgttgccggt ttcccacttt tctttttaca   1320

ttaatgcata gctgcttcca tttatgagac tttagagttt gagtttctgt agggctgaat   1380

gactcttttt cctgcccagg gcccattctt gcttctcagg caccttccgt ttattaattg   1440

ccattgctcc tgacatcact aagatgggtc cccttctggc tgcatgaatg gaaatgagtg   1500

actggaaatc ccataggcca caagaatgac tttcacaagg gcaggaacat tgtggaaaga   1560

ctgcatcatt ctgatgaggc aaaatcctcc agctattcct gtctgggcca gttttgtagg   1620

tccatctgtg catgggcagc agtagtcaaa aagccaagga aaaaacagag cagacctgaa   1680

ggctaatctt atttttgcca ctaacttagt gaatgaccct aagcaagttc cttctcctct   1740

tagggccttg tgccaagcct atgaaattgg aggtggcttt cctgctctaa agcattttga   1800

tgtctcattc tgtgtttggt aacccctata aactggggca gaggaaaaga atgatggttc   1860

aaggccatac ttcccttgaa ccttgtgtgg ttcttgccta actctgtggt ttttggaccc   1920

catggggccc agacagagca caggagcatg ggctgcctct gagtgtggtg ttgaacttcg   1980

ggaggagcag ggagccctgc accttgtgtc ctggcccacc tgacctttgg tgttctccgg   2040

atccttttca gcccgaggcc tgacagacgc gggcagtgat gagccctgtt ctggagtgga   2100

aagagcacga tagagcacca ggctaagagg cacgagatca aggcggtagt cacttccgct   2160

ctgcagctag catttcaacc atatgtggat cctttcattt ctcagctccc tggattcctt   2220

cccctaaatt aggacctatt atttacctgt aggtaagcaa gctactgtag ctcttctgag   2280

gtatctgcca ggctgttttc tgtagcctca gattgcctat ctgcttagcc tgagaacagg   2340

tagatgaaaa ctaaactgat gcctaggccc agggtcagtc tcagatggaa gctgggcctg   2400

ggtggggagg ctagcatgcg tggctccctg ggtatttctg tcagtcccca tggcaagcag   2460

tgatttagta aaacacccca gagtcaggga agccaaccac cttgaaacct ttagaacatc   2520

tctgctttgg agaaagaccc agagatcagg cagaggtgca gattcaatca ttactcataa   2580

cctttgagag ctggcaaatg ggaggagtgt tagtctttgt tttggaattg gaccattctt   2640

gcaaccaaaa ggacttagag cagtttgctc ataaagacat cctttattat aaaaggaagt   2700

atttaaagga tgatagagac catcagatag aagcagggaa ggtagataac ttttaggacc   2760

ttgatgtgag gaaaagataa aatttaaaca ataaatttgc cacttagatt ttctagcagc   2820

aaagtccgaa aagatagtta tatacaaaat tctgttttct gaaaacaaaa ttgtgattca   2880

ccttcagaat tggccatttt ttttgtgagt ttccttgcat caaggacact gagaaacaca   2940

gtcattgtct taggtgttct atgggaggaa gtgaatagag cctttaggaa cttcctggtc   3000

aagcttatgg tgcttatttt gatctgggcc acttccctcc ttccagtcat gagtaatcat   3060

caaggagcaa gttggagtgt ttcaggtgta tattttgtag aacccaaaag attggagcct   3120

taacaataaa catcagcact aagtgacctg ttaaaaaa                           3158


<210>  3823
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  3823

Met Ala Gly Leu Glu Val Leu Phe Ala Ser Ala Ala Pro Ala Ile Thr 
1               5                   10                  15      


Cys Arg Gln Asp Ala Leu Val Cys Phe Leu His Trp Glu Val Val Thr 
            20                  25                  30          


His Gly Tyr Cys Gly Leu Gly Val Gly Asp Gln Pro Gly Pro Asn Asp 
        35                  40                  45              


Lys Lys Ser Glu Leu Leu Pro Ala Gly Trp Asn Asn Asn Lys Asp Leu 
    50                  55                  60                  


Tyr Val Leu Arg Tyr Glu Tyr Lys Asp Gly Ser Arg Lys Leu Leu Val 
65                  70                  75                  80  


Lys Ala Ile Thr Val Glu Ser Ser Met Ile Leu Asn Val Leu Asp Leu 
                85                  90                  95      


Gln Glu Gln 
            


<210>  3824
<211>  5274
<212>  DNA
<213>  Homosapiens

<400>  3824
gcaggtgggg ccgccgcgga actccaggtc cggccgggag cagaggggcg ggggcgagag     60

ggaagtgggc gggagccgcg atctgagtag ccagcgtcgc cggcgaccgc ggagttctgg    120

gctagtggga ccccgcgcgg gctggttcgg gatgagcgat ggcatcggtc aaggtggccg    180

tgagggtccg gcccatgaat cgcagggaaa aggacttgga ggccaagttc attattcaga    240

tggagaaaag caaaacgaca atcacaaact taaagatacc agaaggaggc actggggact    300

caggaagaga acggaccaag accttcacct atgacttttc tttttattct gctgatacaa    360

aaagcccaga ttacgtttca caagaaatgg ttttcaaaac cctcggcaca gatgtcgtga    420

agtctgcatt tgaaggttat aatgcttgtg tctttgcata tgggcaaact ggatctggaa    480

agtcatacac tatgatggga aattctggag attctggctt aatacctcgg atctgtgaag    540

gactcttcag tcggataaat gaaaccacca gatgggatga agcttctttt cgaactgaag    600

tcagctactt agaaatttat aacgaacgtg tgagagatct acttcggcgg aagtcatcta    660

aaaccttcaa tttgagagtc cgtgagcatc ccaaagaagg cccttatgtt gaggatttat    720

ccaaacattt agtacagaat tatggtgacg tagaagaact tatggatgcg ggcaatatca    780

accggaccac cgcagcgact gggatgaacg acgtcagtag caggtctcat gccatcttca    840

ccatcaagtt cactcaggct aaatttgatt ctgaaatgcc atgtgaaacc gtcagtaaga    900

tccacttggt tgatcttgcc ggaagtgagc gtgcagatgc caccggagcc accggggtta    960

ggctaaagga agggggaaat attaacaagt ccctcgtgac tctggggaac gtcatttctg   1020

ccttagctga tttatctcag gatgctgcaa atactcttgc aaagaagaag caagttttcg   1080

tgccttacag ggattctgtg ttgacttggt tgttaaaaga tagccttgga ggaaactcta   1140

aaactatcat gattgccacc atttcacctg ctgatgtcaa ttatggagaa accctaagta   1200

ctcttcgcta tgcaaataga gccaaaaaca tcatcaacaa gcctaccatt aatgaggatg   1260

ccaacgtcaa acttatccgt gagctgcgag ctgaaatagc cagactgaaa acgctgcttg   1320

ctcaagggaa tcagattgcc ctcttagact cccccacagc tttaagtatg gaggaaaaac   1380

ttcagcagaa tgaagcaaga gttcaagaat tgaccaagga atggacaaat aagtggaatg   1440

aaacccaaaa tattttgaaa gaacaaactc tagccctcag gaaagaaggg attggagttg   1500

ttttggattc tgaactgcct catttgattg gcatcgatga tgaccttttg agtactggaa   1560

tcatcttata tcatttaaag gaaggtcaga catacgttgg tagagacgat gcttccacgg   1620

agcaagatat tgttcttcat ggccttgact tggagagtga gcattgcatc tttgaaaata   1680

tcggggggac agtgactctg atacccctga gtgggtccca gtgctctgtg aatggtgttc   1740

agatcgtgga ggccacacat ctaaatcaag gtgctgtgat tctcttggga agaaccaata   1800

tgtttcgctt taaccatcca aaggaagccg ccaagctcag ggagaagagg aagagtggcc   1860

ttctgtcctc cttcagcttg tccatgaccg acctctcgaa gtcccgtgag aacctgtctg   1920

cagtcatgtt gtataacccc ggacttgaat ttgagaggca acagcgtgaa gaacttgaaa   1980

aattagaaag taaaaggaaa ctcatagaag aaatggagga aaagcagaaa tcagacaagg   2040

ctgaactgga gcggatgcag caggaggtgg agacccagcg caaggagaca gaaatcgtgc   2100

agctccagat tcgcaagcag gaggagagcc tcaaacgccg cagcttccac atcgagaaca   2160

agctaaagga tttacttgcg gagaaggaaa aatttgaaga ggagaggctg agggaacagc   2220

aggaaatcga gctgcagaag aagagacaag aagaagagac ctttctccgc gtccaagaag   2280

aactccaacg actcaaagaa ctcaacaaca acgagaaggc tgagaagttt cagatatttc   2340

aagaactgga ccagctccaa aaggaaaaag atgaacagta tgccaagctt gaactggaaa   2400

aaaagagact agaggagcag gagaaggagc aggtcatgct cgtggcccat ctggaagagc   2460

agctccgaga gaagcaggag atgatccagc tcctgcggcg tggggaggta cagtgggtgg   2520

aagaggagaa gagggacctg gaaggcattc gggaatccct cctgcgggtg aaggaggctc   2580

gtgccggagg ggatgaagat ggcgaggagt tagaaaaggc tcaactgcgt ttcttcgaat   2640

tcaagagaag gcagcttgtc aagctagtga acttggagaa ggacctggtt cagcagaaag   2700

acatcctgaa aaaagaagtc caagaagaac aggagatcct agagtgttta aaatgtgaac   2760

atgacaaaga atctagattg ttggaaaaac atgatgagag tgtcacagat gtcacggaag   2820

tgcctcaaga tttcgagaaa ataaagccag tggagtacag gctgcaatat aaagaacgcc   2880

agctacagta cctcctgcag aatcacttgc caactctgtt ggaagaaaag cagagagcat   2940

ttgaaattct tgacagaggc cctctcagct tagacaacac tctttatcaa gtagaaaagg   3000

aaatggaaga aaaagaagaa cagcttgcac agtaccaggc caatgcaaac cagctgcaaa   3060

agctccaagc cacctttgaa ttcactgcca acattgcacg tcaggaggaa aaagtgagga   3120

aaaaggaaaa ggagattttg gagtccagag agaagcagca gagagaggcg ctggagcggg   3180

ccctggccag gctggagagg agacattctg cgctgcagag gcactccacc ctgggcatgg   3240

agattgaaga gcagaggcag aaacttgcca gtctgaacag tggcagcaga gagcagtcag   3300

ggctccaggc tagcctggag gctgagcagg aagccctgga gaaggaccag gagaggttag   3360

aatatgaaat ccagcagctg aaacagaaga tttatgaggt cgatggtgtt caaaaagatc   3420

atcatgggac cctggaaggg aaggtggctt cttccagctt gccagtcagt gctgaaaaat   3480

cacacctggt tcccctcatg gatgccagga tcaatgctta cattgaagaa gaagtccaaa   3540

gacgccttca ggatttgcat cgtgtgatta gtgaaggctg cagtacatct gcagacacga   3600

tgaaggataa tgagaaactt cacaatggca ccattcaacg taaactaaaa tatgagcgga   3660

tggtttctcg ctctttgggc gcaaatccag atgacctgaa ggacccaatt aaaattagta   3720

tcccacgcta cgtcctctgc gggcaaggaa aggatgcaca cttcgagttt gaggtcaaga   3780

ttactgtcct agatgagaca tggactgtat tcaggcgtta cagtcgtttt cgagaaatgc   3840

ataaaacatt gaagttaaag tatgcagagc ttgctgccct tgaatttcct ccaaagaaac   3900

tatttggaaa taaggatgaa cgtgtgattg ctgagagacg aagtcactta gagaaatacc   3960

tcagggactt tttcagcgtg atgctccagt ccgcaacatc tcccctccac atcaacaaag   4020

tgggactgac tctctcgaaa cataccattt gtgagttttc accattcttc aagaaaggag   4080

tctttgacta cagcagccac gggacggggt agagccaggg gtgatggagg aaccaccaca   4140

gcagtgcctt ctcgtcgaag cgggctccga tgcagggcag ctcccccatg cgaggatccg   4200

ggtctgcctc ctcctgctga agacagacat gcagcagcgg gcccgggcca cctcacgttt   4260

ccatacctag tgcctgagtt tggggatggg atgctctgcc tgctgatgtg gccctgacag   4320

gcagccgtta ccgttccatt gcggttgaac gtggcctttt cccacagtgc ttccttctca   4380

ctgcgcagca aagttcgtcc cctgtggcaa gatagatgtg gttgggccat cgtgggttcc   4440

ctgagcccag ccagcctggg acctcccaaa gtgggtggct taccagacca cccttaaatg   4500

actttcatct ggtttcctct ttcaccaaaa tatactcgta ttttttatat ttcttccatg   4560

tggctggcta tattccaaga aaagcatttt aaattatttc attgtatttt tttctttttt   4620

tccctcattt gaatcagaac ttttatataa aacccaaaca ctgatgttta cacagaattt   4680

catattctgc aaaagggatt ttttgatcca atcatgactg tagtcttcca tgcttgacaa   4740

attggatgta gacaacatta cttaaaactt ctataaatcc ctacaattag gatatttatt   4800

taaccttgaa tattcaagaa cattctccca aatctaaatg gctactgtgc attcttgagc   4860

tttttctgct aagcacaaaa tgaacgcaaa gctaaatgca tatttttaag tattattcac   4920

attttttgtt acagaatcta ttggatcttt ggctggaaaa ctagaattta tagcagttta   4980

ttaatgatac cttaaattac tcaggactta atgtagcatt gcacttctgt gtacagtaaa   5040

actgctttgt tttactaaag agaaaaatgt gagtggaaaa aatatgtatg tggtatatac   5100

tcaaatgtat ataattctat ctatagattt atatatgtat acattctgta cagtagttcc   5160

atcaaaatat gtaataattc acaccaattt tattaaatgt atttgctttt tcaaaattta   5220

aattgagctg ctatcaatat taaatgaagt tatggcatct aaaaaaaaaa aaaa         5274


<210>  3825
<211>  1317
<212>  PRT
<213>  Homosapiens

<400>  3825

Met Ala Ser Val Lys Val Ala Val Arg Val Arg Pro Met Asn Arg Arg 
1               5                   10                  15      


Glu Lys Asp Leu Glu Ala Lys Phe Ile Ile Gln Met Glu Lys Ser Lys 
            20                  25                  30          


Thr Thr Ile Thr Asn Leu Lys Ile Pro Glu Gly Gly Thr Gly Asp Ser 
        35                  40                  45              


Gly Arg Glu Arg Thr Lys Thr Phe Thr Tyr Asp Phe Ser Phe Tyr Ser 
    50                  55                  60                  


Ala Asp Thr Lys Ser Pro Asp Tyr Val Ser Gln Glu Met Val Phe Lys 
65                  70                  75                  80  


Thr Leu Gly Thr Asp Val Val Lys Ser Ala Phe Glu Gly Tyr Asn Ala 
                85                  90                  95      


Cys Val Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Ser Tyr Thr Met 
            100                 105                 110         


Met Gly Asn Ser Gly Asp Ser Gly Leu Ile Pro Arg Ile Cys Glu Gly 
        115                 120                 125             


Leu Phe Ser Arg Ile Asn Glu Thr Thr Arg Trp Asp Glu Ala Ser Phe 
    130                 135                 140                 


Arg Thr Glu Val Ser Tyr Leu Glu Ile Tyr Asn Glu Arg Val Arg Asp 
145                 150                 155                 160 


Leu Leu Arg Arg Lys Ser Ser Lys Thr Phe Asn Leu Arg Val Arg Glu 
                165                 170                 175     


His Pro Lys Glu Gly Pro Tyr Val Glu Asp Leu Ser Lys His Leu Val 
            180                 185                 190         


Gln Asn Tyr Gly Asp Val Glu Glu Leu Met Asp Ala Gly Asn Ile Asn 
        195                 200                 205             


Arg Thr Thr Ala Ala Thr Gly Met Asn Asp Val Ser Ser Arg Ser His 
    210                 215                 220                 


Ala Ile Phe Thr Ile Lys Phe Thr Gln Ala Lys Phe Asp Ser Glu Met 
225                 230                 235                 240 


Pro Cys Glu Thr Val Ser Lys Ile His Leu Val Asp Leu Ala Gly Ser 
                245                 250                 255     


Glu Arg Ala Asp Ala Thr Gly Ala Thr Gly Val Arg Leu Lys Glu Gly 
            260                 265                 270         


Gly Asn Ile Asn Lys Ser Leu Val Thr Leu Gly Asn Val Ile Ser Ala 
        275                 280                 285             


Leu Ala Asp Leu Ser Gln Asp Ala Ala Asn Thr Leu Ala Lys Lys Lys 
    290                 295                 300                 


Gln Val Phe Val Pro Tyr Arg Asp Ser Val Leu Thr Trp Leu Leu Lys 
305                 310                 315                 320 


Asp Ser Leu Gly Gly Asn Ser Lys Thr Ile Met Ile Ala Thr Ile Ser 
                325                 330                 335     


Pro Ala Asp Val Asn Tyr Gly Glu Thr Leu Ser Thr Leu Arg Tyr Ala 
            340                 345                 350         


Asn Arg Ala Lys Asn Ile Ile Asn Lys Pro Thr Ile Asn Glu Asp Ala 
        355                 360                 365             


Asn Val Lys Leu Ile Arg Glu Leu Arg Ala Glu Ile Ala Arg Leu Lys 
    370                 375                 380                 


Thr Leu Leu Ala Gln Gly Asn Gln Ile Ala Leu Leu Asp Ser Pro Thr 
385                 390                 395                 400 


Ala Leu Ser Met Glu Glu Lys Leu Gln Gln Asn Glu Ala Arg Val Gln 
                405                 410                 415     


Glu Leu Thr Lys Glu Trp Thr Asn Lys Trp Asn Glu Thr Gln Asn Ile 
            420                 425                 430         


Leu Lys Glu Gln Thr Leu Ala Leu Arg Lys Glu Gly Ile Gly Val Val 
        435                 440                 445             


Leu Asp Ser Glu Leu Pro His Leu Ile Gly Ile Asp Asp Asp Leu Leu 
    450                 455                 460                 


Ser Thr Gly Ile Ile Leu Tyr His Leu Lys Glu Gly Gln Thr Tyr Val 
465                 470                 475                 480 


Gly Arg Asp Asp Ala Ser Thr Glu Gln Asp Ile Val Leu His Gly Leu 
                485                 490                 495     


Asp Leu Glu Ser Glu His Cys Ile Phe Glu Asn Ile Gly Gly Thr Val 
            500                 505                 510         


Thr Leu Ile Pro Leu Ser Gly Ser Gln Cys Ser Val Asn Gly Val Gln 
        515                 520                 525             


Ile Val Glu Ala Thr His Leu Asn Gln Gly Ala Val Ile Leu Leu Gly 
    530                 535                 540                 


Arg Thr Asn Met Phe Arg Phe Asn His Pro Lys Glu Ala Ala Lys Leu 
545                 550                 555                 560 


Arg Glu Lys Arg Lys Ser Gly Leu Leu Ser Ser Phe Ser Leu Ser Met 
                565                 570                 575     


Thr Asp Leu Ser Lys Ser Arg Glu Asn Leu Ser Ala Val Met Leu Tyr 
            580                 585                 590         


Asn Pro Gly Leu Glu Phe Glu Arg Gln Gln Arg Glu Glu Leu Glu Lys 
        595                 600                 605             


Leu Glu Ser Lys Arg Lys Leu Ile Glu Glu Met Glu Glu Lys Gln Lys 
    610                 615                 620                 


Ser Asp Lys Ala Glu Leu Glu Arg Met Gln Gln Glu Val Glu Thr Gln 
625                 630                 635                 640 


Arg Lys Glu Thr Glu Ile Val Gln Leu Gln Ile Arg Lys Gln Glu Glu 
                645                 650                 655     


Ser Leu Lys Arg Arg Ser Phe His Ile Glu Asn Lys Leu Lys Asp Leu 
            660                 665                 670         


Leu Ala Glu Lys Glu Lys Phe Glu Glu Glu Arg Leu Arg Glu Gln Gln 
        675                 680                 685             


Glu Ile Glu Leu Gln Lys Lys Arg Gln Glu Glu Glu Thr Phe Leu Arg 
    690                 695                 700                 


Val Gln Glu Glu Leu Gln Arg Leu Lys Glu Leu Asn Asn Asn Glu Lys 
705                 710                 715                 720 


Ala Glu Lys Phe Gln Ile Phe Gln Glu Leu Asp Gln Leu Gln Lys Glu 
                725                 730                 735     


Lys Asp Glu Gln Tyr Ala Lys Leu Glu Leu Glu Lys Lys Arg Leu Glu 
            740                 745                 750         


Glu Gln Glu Lys Glu Gln Val Met Leu Val Ala His Leu Glu Glu Gln 
        755                 760                 765             


Leu Arg Glu Lys Gln Glu Met Ile Gln Leu Leu Arg Arg Gly Glu Val 
    770                 775                 780                 


Gln Trp Val Glu Glu Glu Lys Arg Asp Leu Glu Gly Ile Arg Glu Ser 
785                 790                 795                 800 


Leu Leu Arg Val Lys Glu Ala Arg Ala Gly Gly Asp Glu Asp Gly Glu 
                805                 810                 815     


Glu Leu Glu Lys Ala Gln Leu Arg Phe Phe Glu Phe Lys Arg Arg Gln 
            820                 825                 830         


Leu Val Lys Leu Val Asn Leu Glu Lys Asp Leu Val Gln Gln Lys Asp 
        835                 840                 845             


Ile Leu Lys Lys Glu Val Gln Glu Glu Gln Glu Ile Leu Glu Cys Leu 
    850                 855                 860                 


Lys Cys Glu His Asp Lys Glu Ser Arg Leu Leu Glu Lys His Asp Glu 
865                 870                 875                 880 


Ser Val Thr Asp Val Thr Glu Val Pro Gln Asp Phe Glu Lys Ile Lys 
                885                 890                 895     


Pro Val Glu Tyr Arg Leu Gln Tyr Lys Glu Arg Gln Leu Gln Tyr Leu 
            900                 905                 910         


Leu Gln Asn His Leu Pro Thr Leu Leu Glu Glu Lys Gln Arg Ala Phe 
        915                 920                 925             


Glu Ile Leu Asp Arg Gly Pro Leu Ser Leu Asp Asn Thr Leu Tyr Gln 
    930                 935                 940                 


Val Glu Lys Glu Met Glu Glu Lys Glu Glu Gln Leu Ala Gln Tyr Gln 
945                 950                 955                 960 


Ala Asn Ala Asn Gln Leu Gln Lys Leu Gln Ala Thr Phe Glu Phe Thr 
                965                 970                 975     


Ala Asn Ile Ala Arg Gln Glu Glu Lys Val Arg Lys Lys Glu Lys Glu 
            980                 985                 990         


Ile Leu Glu Ser Arg Glu Lys Gln  Gln Arg Glu Ala Leu  Glu Arg Ala 
        995                 1000                 1005             


Leu Ala  Arg Leu Glu Arg Arg  His Ser Ala Leu Gln  Arg His Ser 
    1010                 1015                 1020             


Thr Leu  Gly Met Glu Ile Glu  Glu Gln Arg Gln Lys  Leu Ala Ser 
    1025                 1030                 1035             


Leu Asn  Ser Gly Ser Arg Glu  Gln Ser Gly Leu Gln  Ala Ser Leu 
    1040                 1045                 1050             


Glu Ala  Glu Gln Glu Ala Leu  Glu Lys Asp Gln Glu  Arg Leu Glu 
    1055                 1060                 1065             


Tyr Glu  Ile Gln Gln Leu Lys  Gln Lys Ile Tyr Glu  Val Asp Gly 
    1070                 1075                 1080             


Val Gln  Lys Asp His His Gly  Thr Leu Glu Gly Lys  Val Ala Ser 
    1085                 1090                 1095             


Ser Ser  Leu Pro Val Ser Ala  Glu Lys Ser His Leu  Val Pro Leu 
    1100                 1105                 1110             


Met Asp  Ala Arg Ile Asn Ala  Tyr Ile Glu Glu Glu  Val Gln Arg 
    1115                 1120                 1125             


Arg Leu  Gln Asp Leu His Arg  Val Ile Ser Glu Gly  Cys Ser Thr 
    1130                 1135                 1140             


Ser Ala  Asp Thr Met Lys Asp  Asn Glu Lys Leu His  Asn Gly Thr 
    1145                 1150                 1155             


Ile Gln  Arg Lys Leu Lys Tyr  Glu Arg Met Val Ser  Arg Ser Leu 
    1160                 1165                 1170             


Gly Ala  Asn Pro Asp Asp Leu  Lys Asp Pro Ile Lys  Ile Ser Ile 
    1175                 1180                 1185             


Pro Arg  Tyr Val Leu Cys Gly  Gln Gly Lys Asp Ala  His Phe Glu 
    1190                 1195                 1200             


Phe Glu  Val Lys Ile Thr Val  Leu Asp Glu Thr Trp  Thr Val Phe 
    1205                 1210                 1215             


Arg Arg  Tyr Ser Arg Phe Arg  Glu Met His Lys Thr  Leu Lys Leu 
    1220                 1225                 1230             


Lys Tyr  Ala Glu Leu Ala Ala  Leu Glu Phe Pro Pro  Lys Lys Leu 
    1235                 1240                 1245             


Phe Gly  Asn Lys Asp Glu Arg  Val Ile Ala Glu Arg  Arg Ser His 
    1250                 1255                 1260             


Leu Glu  Lys Tyr Leu Arg Asp  Phe Phe Ser Val Met  Leu Gln Ser 
    1265                 1270                 1275             


Ala Thr  Ser Pro Leu His Ile  Asn Lys Val Gly Leu  Thr Leu Ser 
    1280                 1285                 1290             


Lys His  Thr Ile Cys Glu Phe  Ser Pro Phe Phe Lys  Lys Gly Val 
    1295                 1300                 1305             


Phe Asp  Tyr Ser Ser His Gly  Thr Gly 
    1310                 1315         


<210>  3826
<211>  2437
<212>  DNA
<213>  Homosapiens

<400>  3826
agacactggc cgcgggccac catctggacg cgatcccccg ctagggcctc cctggtctgg     60

gccaaagttg gtggccacct tcgcgcgggc tgcgccctcc ttctcttccc tgccctcctc    120

ccccggggcc cgcgcccgct gcctccagca cgcgcgtcgg caggctcggc aagcgaagag    180

gagcggctcg ccccagggcg cccctcgccc agcctgccgg ccaggcgagc gcgacgagag    240

tctccccgca ccccttcctc tcccgggggc cgagagggtt gggctccgcc ccggcgccgc    300

agctcccgac tccccgccgc tcgggctgcc gccgctgccc cgcgcccggc gctcggggca    360

gccgggggcg caggcggaga gcgcagggcg gggagaggcg tggggagcag agcggcgctg    420

aggggagggc agaggaggag agagcctggc agcggaggag cagaggcggg cgccgcaccg    480

ccccgcacgc tcgctcgctc gggagagtcg cgggcggccg cttgggcgca cttgccgggt    540

caccttgtcc cggaggagaa atggcttccc tgaggcaagt gtaacctaca ttcccagccc    600

accagcctga cgcccagcca gggagagagt accatggatg gcatcattga acagaagagc    660

atgctggtgc acagtaaaat cagtgatgct ggcaagagga atggtttaat taacaccaga    720

aacttgatgg ccgagagcag agatggtctg gtgtctgttt acccagcgcc ccagtaccag    780

agccaccggg tgggggccag cacagtgccg gccagcctgg acagcagcag gagtgagccg    840

atgcagcagc tgctggaccc caacaccctg cagcagtcag tggagtcccg ctaccggccc    900

aacatcatcc tctattcaga gggcgtgctg cgctcctggg gggacggtgt ggccgccgac    960

tgctgcgaga ccaccttcat cgaggaccgg tcgcccacca aagacagcct cgagtacccg   1020

gatgggaagt tcattgacct ctcagctgat gacataaaaa tccacaccct gtcctacgat   1080

gtggaggagg aggaggagtt ccaggagctg gagagcgact actcaagcga cacagagagt   1140

gaggacaatt tcctcatgat gcccccgcgg gaccacctgg gcctcagtgt cttctccatg   1200

ctctgctgct tctggcctct gggcatcgca gccttctact tgtcccatga gaccaacaaa   1260

gccgtggcca agggggactt gcaccaggcc agcaccagct cccggcgggc cctattcctg   1320

gcagtgctgt ccatcaccat tgggactggc gtctatgtgg gcgtggccgt ggccctcatc   1380

gcctacctct ccaagaacaa ccacctgtga gcttcctgcg aatggagggg gagcacccgg   1440

ggccaggtct gtgtggacgt ggaggaagca ggcataccgc atgatgctgt acagtacaaa   1500

tgattgccaa atgatgccac gaagccctgg gatttcctac ccatggattt attttgtttt   1560

tatcctttaa tttcatgttc acagcactgt gtagagcacc agacagacgg gcactgctaa   1620

tccttccaaa ggaaagctcc aaagatccca gcccgcaagg ctgtctctgg atggattctg   1680

gtggatgaat ggcaacgcgg ctctctgcag cctgccagtg cccagagtgc caccgcatta   1740

gcaatataca aacagtccaa aaaagtgttt attttttatg gaatacggtg caataggcag   1800

aggacaaggg acacatcact cttctgtctg tggccctgct ggagtccttt gtgccccccg   1860

gagtccacac gccttccctg caagacgaga atggggctgg gaagaaagag gcaacaccac   1920

ggctggcagg agccccgctg cactgctctg cagacccatt ggcctgaccc tgagaagcag   1980

agccagcaaa gcccgggacc tgcccctctt tctttccctt cacaccaccc cagcctcagg   2040

atgtcaagcc acctccggaa cgtgtctaca ctccacagct accccgcagc aatacgcact   2100

cttgggacct cgctgatcta ggatggggag gcaggccacc gcccctccca agactcctca   2160

agaaagagcc ccgcggttgc tccggaaact cgaggcactg cagctatggg cactgcctca   2220

gcctaaagac acaggggcgc ctcccaatca ccgcgctggc ggatgctcac cccgtcataa   2280

gcagaaacta gtgatcctgg aaatgagatg ggccttactc tgtcgactaa atgaatagct   2340

attttcttgt cattttttaa agtgcaactc ttgcttcatg ctgcttaagt taccagatga   2400

atgctgagaa ataagtaatc acagacattt taatacc                            2437


<210>  3827
<211>  258
<212>  PRT
<213>  Homosapiens

<400>  3827

Met Asp Gly Ile Ile Glu Gln Lys Ser Met Leu Val His Ser Lys Ile 
1               5                   10                  15      


Ser Asp Ala Gly Lys Arg Asn Gly Leu Ile Asn Thr Arg Asn Leu Met 
            20                  25                  30          


Ala Glu Ser Arg Asp Gly Leu Val Ser Val Tyr Pro Ala Pro Gln Tyr 
        35                  40                  45              


Gln Ser His Arg Val Gly Ala Ser Thr Val Pro Ala Ser Leu Asp Ser 
    50                  55                  60                  


Ser Arg Ser Glu Pro Met Gln Gln Leu Leu Asp Pro Asn Thr Leu Gln 
65                  70                  75                  80  


Gln Ser Val Glu Ser Arg Tyr Arg Pro Asn Ile Ile Leu Tyr Ser Glu 
                85                  90                  95      


Gly Val Leu Arg Ser Trp Gly Asp Gly Val Ala Ala Asp Cys Cys Glu 
            100                 105                 110         


Thr Thr Phe Ile Glu Asp Arg Ser Pro Thr Lys Asp Ser Leu Glu Tyr 
        115                 120                 125             


Pro Asp Gly Lys Phe Ile Asp Leu Ser Ala Asp Asp Ile Lys Ile His 
    130                 135                 140                 


Thr Leu Ser Tyr Asp Val Glu Glu Glu Glu Glu Phe Gln Glu Leu Glu 
145                 150                 155                 160 


Ser Asp Tyr Ser Ser Asp Thr Glu Ser Glu Asp Asn Phe Leu Met Met 
                165                 170                 175     


Pro Pro Arg Asp His Leu Gly Leu Ser Val Phe Ser Met Leu Cys Cys 
            180                 185                 190         


Phe Trp Pro Leu Gly Ile Ala Ala Phe Tyr Leu Ser His Glu Thr Asn 
        195                 200                 205             


Lys Ala Val Ala Lys Gly Asp Leu His Gln Ala Ser Thr Ser Ser Arg 
    210                 215                 220                 


Arg Ala Leu Phe Leu Ala Val Leu Ser Ile Thr Ile Gly Thr Gly Val 
225                 230                 235                 240 


Tyr Val Gly Val Ala Val Ala Leu Ile Ala Tyr Leu Ser Lys Asn Asn 
                245                 250                 255     


His Leu 
        


<210>  3828
<211>  928
<212>  DNA
<213>  Homosapiens

<400>  3828
gctgtggccc tggcacctgc ccctgggctg ggacagccca ctgttccatg ctgcccaaga     60

aggctcagca caggcacaaa ccattgcccg gcactggccc gtgctgcctg agaaggattg    120

gcacgggcac agaccactgc ccccacctgc cctgcgccat ctacccaaga aggctcggca    180

cgggcaccaa ccactgcctc caactgcccc atgctgcctg agaaggcact gcacggccac    240

ccccaactgc cccgcactgt ccctacccgg gcagccatgc gagcggctgg aactctgctg    300

gccttctgct gcctggtctt gagcaccact gggggccctt ccccagatac ttgttcccag    360

gaccttaact cacgtgtgaa gccaggattt cctaaaacaa taaagaccaa tgacccagga    420

gtcctccaag cagccagata cagtgttgaa aagttcaaca actgcacgaa cgacatgttc    480

ttgttcaagg agtcccgcat cacaagggcc ctagttcaga tagtgaaagg cctgaaatat    540

atgctggagg tggaaattgg cagaactacc tgcaagaaaa accagcacct gcgtctggat    600

gactgtgact tccaaaccaa ccacaccttg aagcagactc tgagctgcta ctctgaagtc    660

tgggtcgtgc cctggctcca gcacttcgag gtgcctgttc tccgttgtca ctgacccccg    720

cctcttcagc aagaccacag ccatgacaaa caccaggatg catgctcctt gtcccctccc    780

acccgcctca tgacccagcc tcacagaccc tctcaggcct ctgacgagtg agcgggtgaa    840

gtgccactgg gtcaccgcag ggcagctgga atggcagcat ggtagcacct cctaacagat    900

taaatagatc acatttgctt ctaaaatt                                       928


<210>  3829
<211>  167
<212>  PRT
<213>  Homosapiens

<400>  3829

Met Leu Pro Glu Lys Ala Leu His Gly His Pro Gln Leu Pro Arg Thr 
1               5                   10                  15      


Val Pro Thr Arg Ala Ala Met Arg Ala Ala Gly Thr Leu Leu Ala Phe 
            20                  25                  30          


Cys Cys Leu Val Leu Ser Thr Thr Gly Gly Pro Ser Pro Asp Thr Cys 
        35                  40                  45              


Ser Gln Asp Leu Asn Ser Arg Val Lys Pro Gly Phe Pro Lys Thr Ile 
    50                  55                  60                  


Lys Thr Asn Asp Pro Gly Val Leu Gln Ala Ala Arg Tyr Ser Val Glu 
65                  70                  75                  80  


Lys Phe Asn Asn Cys Thr Asn Asp Met Phe Leu Phe Lys Glu Ser Arg 
                85                  90                  95      


Ile Thr Arg Ala Leu Val Gln Ile Val Lys Gly Leu Lys Tyr Met Leu 
            100                 105                 110         


Glu Val Glu Ile Gly Arg Thr Thr Cys Lys Lys Asn Gln His Leu Arg 
        115                 120                 125             


Leu Asp Asp Cys Asp Phe Gln Thr Asn His Thr Leu Lys Gln Thr Leu 
    130                 135                 140                 


Ser Cys Tyr Ser Glu Val Trp Val Val Pro Trp Leu Gln His Phe Glu 
145                 150                 155                 160 


Val Pro Val Leu Arg Cys His 
                165         


<210>  3830
<211>  2251
<212>  DNA
<213>  Homosapiens

<400>  3830
gcgcaacgtc atttccgcgt acgggggagg gcgggcctgg agtctgagcc ggcgccgctc     60

agtgtgaggt ggtttctgcg ggtgaggctg gcgcccgtac catgagcgag gcggacgggc    120

tgcgacagcg ccggcccctg cggccgcagg tcgtcacaga cgatgatggc caggccccgg    180

aggctaagga cggcagctcc tttagcggca gagttttccg agtgaccttc ttgatgctgg    240

ctgtttctct caccgttccc ctgcttggag ccatgatgct gctggaatct cctatagatc    300

cacagcctct cagcttcaaa gaacccccgc tcttgcttgg tgttctgcat ccaaatacga    360

agctgcgaca ggcagaaagg ctgtttgaaa atcaacttgt tggaccggag tccatagcac    420

atattgggga tgtgatgttt actgggacag cagatggccg ggtcgtaaaa cttgaaaatg    480

gtgaaataga gaccattgcc cggtttggtt cgggcccttg caaaacccga gatgatgagc    540

ctgtgtgtgg gagacccctg ggtatccgtg cagggcccaa tgggactctc tttgtggccg    600

atgcatacaa gggactattt gaagtaaatc cctggaaacg tgaagtgaaa ctgctgctgt    660

cctccgagac acccattgag gggaagaaca tgtcctttgt gaatgatctt acagtcactc    720

aggatgggag gaagatttat ttcaccgatt ctagcagcaa atggcaaaga cgagactacc    780

tgcttctggt gatggagggc acagatgacg ggcgcctgct ggagtatgat actgtgacca    840

gggaagtaaa agttttattg gaccagctgc ggttcccgaa tggagtccag ctgtctcctg    900

cagaagactt tgtcctggtg gcagaaacaa ccatggccag gatacgaaga gtctacgttt    960

ctggcctgat gaagggcggg gctgatctgt ttgtggagaa catgcctgga tttccagaca   1020

acatccggcc cagcagctct ggggggtact gggtgggcat gtcgaccatc cgccctaacc   1080

ctgggttttc catgctggat ttcttatctg agagaccctg gattaaaagg atgattttta   1140

agctctttag tcaagagacg gtgatgaagt ttgtgccgcg gtacagcctc gtcctagaac   1200

tcagcgacag cggtgccttc cggagaagcc tgcatgatcc cgatgggctg gtggccacct   1260

acatcagcga ggtgcacgaa cacgatgggc acctgtacct gggctctttc aggtccccct   1320

tcctctgcag actcagcctc caggctgttt agccctccca gatagctgcc cctgccacgc   1380

aggccaggag tcttcacact caggcaccag gcctggtcca ggaggagctg tggacacagt   1440

cgtggttcaa gtgtccacat gcacctgtta gtccctgaga ggtggtggga atggctgctt   1500

cattcctcga ggatgcccgg gccccacctg ggcttgtctt tctgtttaga gggaagtgta   1560

acatatctgc catgaggaac ataaattcat gtaaagccat tttctcttaa acaaaacaaa   1620

actttctaag tacagtcatt ctctaggatt tgggaagctc cttgcacttg gaacagggct   1680

caggtgggtg gagcagtaag gcactaccca gagagcttgc tgctgcggcc ctgtcctgcg   1740

gcctcaaagt tcttctttac tatatataac gtgcggtcat acctttcttc gttgtggtgg   1800

ggatggaaga gcagagggag catggcccag gggtgttgag gccagcggtg agagccgtgt   1860

tagccaagac atggaactgt gttctcaagg gttatgtggg gcgtgggctc tccatagtgt   1920

gtatgaaaag cttgttgact ctagcggctc agagaggact ttgctgggtt tctttctgtg   1980

aatatctccg tgctgaccat gctggaattg gatgattctg caattcggga cctactgcag   2040

gggtccgttt agtaacgtct tgtctgtgat ctttgttctt gacctctaga ccccaagatg   2100

tgaacagtgc acgtgttaat gtcatctttg ctcatgtgtt ataagcccca agttgctgta   2160

tattttcaca agtatgtcta cacactggtc atgattttga taataaataa cgataaatcg   2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                  2251


<210>  3831
<211>  416
<212>  PRT
<213>  Homosapiens

<400>  3831

Met Ser Glu Ala Asp Gly Leu Arg Gln Arg Arg Pro Leu Arg Pro Gln 
1               5                   10                  15      


Val Val Thr Asp Asp Asp Gly Gln Ala Pro Glu Ala Lys Asp Gly Ser 
            20                  25                  30          


Ser Phe Ser Gly Arg Val Phe Arg Val Thr Phe Leu Met Leu Ala Val 
        35                  40                  45              


Ser Leu Thr Val Pro Leu Leu Gly Ala Met Met Leu Leu Glu Ser Pro 
    50                  55                  60                  


Ile Asp Pro Gln Pro Leu Ser Phe Lys Glu Pro Pro Leu Leu Leu Gly 
65                  70                  75                  80  


Val Leu His Pro Asn Thr Lys Leu Arg Gln Ala Glu Arg Leu Phe Glu 
                85                  90                  95      


Asn Gln Leu Val Gly Pro Glu Ser Ile Ala His Ile Gly Asp Val Met 
            100                 105                 110         


Phe Thr Gly Thr Ala Asp Gly Arg Val Val Lys Leu Glu Asn Gly Glu 
        115                 120                 125             


Ile Glu Thr Ile Ala Arg Phe Gly Ser Gly Pro Cys Lys Thr Arg Asp 
    130                 135                 140                 


Asp Glu Pro Val Cys Gly Arg Pro Leu Gly Ile Arg Ala Gly Pro Asn 
145                 150                 155                 160 


Gly Thr Leu Phe Val Ala Asp Ala Tyr Lys Gly Leu Phe Glu Val Asn 
                165                 170                 175     


Pro Trp Lys Arg Glu Val Lys Leu Leu Leu Ser Ser Glu Thr Pro Ile 
            180                 185                 190         


Glu Gly Lys Asn Met Ser Phe Val Asn Asp Leu Thr Val Thr Gln Asp 
        195                 200                 205             


Gly Arg Lys Ile Tyr Phe Thr Asp Ser Ser Ser Lys Trp Gln Arg Arg 
    210                 215                 220                 


Asp Tyr Leu Leu Leu Val Met Glu Gly Thr Asp Asp Gly Arg Leu Leu 
225                 230                 235                 240 


Glu Tyr Asp Thr Val Thr Arg Glu Val Lys Val Leu Leu Asp Gln Leu 
                245                 250                 255     


Arg Phe Pro Asn Gly Val Gln Leu Ser Pro Ala Glu Asp Phe Val Leu 
            260                 265                 270         


Val Ala Glu Thr Thr Met Ala Arg Ile Arg Arg Val Tyr Val Ser Gly 
        275                 280                 285             


Leu Met Lys Gly Gly Ala Asp Leu Phe Val Glu Asn Met Pro Gly Phe 
    290                 295                 300                 


Pro Asp Asn Ile Arg Pro Ser Ser Ser Gly Gly Tyr Trp Val Gly Met 
305                 310                 315                 320 


Ser Thr Ile Arg Pro Asn Pro Gly Phe Ser Met Leu Asp Phe Leu Ser 
                325                 330                 335     


Glu Arg Pro Trp Ile Lys Arg Met Ile Phe Lys Leu Phe Ser Gln Glu 
            340                 345                 350         


Thr Val Met Lys Phe Val Pro Arg Tyr Ser Leu Val Leu Glu Leu Ser 
        355                 360                 365             


Asp Ser Gly Ala Phe Arg Arg Ser Leu His Asp Pro Asp Gly Leu Val 
    370                 375                 380                 


Ala Thr Tyr Ile Ser Glu Val His Glu His Asp Gly His Leu Tyr Leu 
385                 390                 395                 400 


Gly Ser Phe Arg Ser Pro Phe Leu Cys Arg Leu Ser Leu Gln Ala Val 
                405                 410                 415     


<210>  3832
<211>  4488
<212>  DNA
<213>  Homosapiens

<400>  3832
aaaaggaaaa cgaggcaccg agaagttaag gaacttgctc aaggtcacag agtttgaact     60

caggctacag atgctgcagc aactggagaa agtcctcatc gccccatatc acccaccacc    120

gacccccagc aggacgtgac ccccgccagg acggaggccg gcagctgggg ggctggagca    180

tgggacccag aacacggact caggcttgcg cagcctcctg gcttctaggc gggagcctag    240

aaaggcgcca gcccctttcg cgtgctgctg agactccagg ggtggggttc actctcaggg    300

gcgcacaaag gcatgaaaac cttggcttca gcctctgaga tgcggaactg accgacctat    360

tgtcttggga cccaccagtg cgcttgggtg caccagcccc cttaacgttg gtgccggctc    420

cctcccggct cctccccatc ccagagggtc ccctcgcccc aggccctgag cctgcgtcct    480

ggggtcctgg gccgcacgtg cctctggcag ctcgaagaag ctgtcggggc ttgcaggaga    540

gcgtgcaaac tgaaaccaaa acaggccgac tcgaggaaca tccgggtggg accgcagact    600

caccggagcg cagcgcctgg gccagggcct gggaccctgc tccgccccgc gctcccctgc    660

accccttccc cacgctgctc ccctcttcct aagcggcccc ccctctcccg ggcagcagaa    720

gaaggggtgg gacccgggcg ggctccggga gggggccctg gaggaatgga tggtggcgga    780

agggcggagc aggggcgggg cccgcggaga ctccacgggg cgccccgggc gtgaggcacc    840

cactctggga gcacagagag ctcaggtagc ctgcctagat ggcggcgcgc accctgggcc    900

gcggcgtcgg gaggctgctg ggcagcctgc gagggctctc ggggcagccc gcgcggccgc    960

cgtgcggggt gagcgcgccg cgcagggcgg cctcgggacc ctcgggcagc gctcccgcag   1020

ttgcagcagc agcagcacag ccaggctcgt atcccgcgct gagtgcacag gcagcccggg   1080

agccggccgc cttctggggg cctctggcgc gggacactct cgtgtgggac accccctacc   1140

acaccgtctg ggactgcgac ttcagcactg gcaagatcgg ctggttcctg ggaggccagt   1200

taaatgtctc tgtcaactgc ttggaccagc atgttcggaa gtcccccgag agcgttgctt   1260

tgatctggga gcgcgatgag cctggaacgg aagtgaggat cacctacagg gaactactgg   1320

agaccacgtg ccgcctggcc aacacgctga agaggcatgg agtccaccgt ggggaccgtg   1380

ttgccatcta catgcccgtg tccccattgg ctgtggcagc aatgctggcc tgtgccagga   1440

tcggagctgt ccacacagtc atctttgctg gcttcagtgc agagtccttg gctgggagga   1500

tcaatgatgc caagtgcaag gtggttatca ccttcaacca aggactccgg ggtgggcgcg   1560

tggtggagct gaagaaaata gtggatgagg ctgtgaagca ctgccccacc gtgcagcatg   1620

tcctggtggc tcacaggaca gacaacaagg tccacatggg ggatctggac gtcccgctgg   1680

agcaggaaat ggccaaggag gaccctgttt gcgccccaga gagcatgggc agtgaggaca   1740

tgctcttcat gctgtacacc tcagggagca ccggaatgcc caagggcatc gtccataccc   1800

aggcaggcta cctgctctat gccgccctga ctcacaagct tgtgtttgac caccagccag   1860

gtgacatctt tggctgtgtg gccgacatcg gttggattac aggacacagc tacgtggtgt   1920

atgggcctct ctgcaatggt gccaccagcg tcctttttga gagcacccca gtttatccca   1980

atgctggtcg gtactgggag acagtagaga ggttgaagat caatcagttc tatggcgccc   2040

caacggctgt ccggctgttg ctgaaatacg gtgatgcctg ggtgaagaag tatgatcgct   2100

cctccctgcg gaccctgggg tcagtgggag agcccatcaa ctgtgaggcc tgggagtggc   2160

ttcacagggt ggtgggggac agcaggtgca cgctggtgga cacctggtgg cagacagaaa   2220

caggtggcat ctgcatcgca ccacggccct cggaagaagg ggcggaaatc ctccctgcca   2280

tggcgatgag gcccttcttt ggcatcgtcc ccgtcctcat ggatgagaag ggcagcgtcg   2340

tggagggcag caacgtctcc ggggccctgt gcatctccca ggcctggccg ggcatggcca   2400

ggaccatcta tggcgaccac cagcgatttg tggacgccta cttcaaggcc tacccaggct   2460

attacttcac tggagacggg gcttaccgaa ctgagggcgg ctattaccag atcacagggc   2520

ggatggatga tgtcatcaac atcagtggcc accggctggg gaccgcagag attgaggacg   2580

ccatcgccga ccaccctgca gtaccagaaa gtgctgtcat tggctacccc cacgacatca   2640

aaggagaagc tgcctttgcc ttcattgtgg tgaaagatag tgcgggtgac tcagatgtgg   2700

tggtgcagga gctcaagtcc atggtggcca ccaagatcgc caaatatgct gtgcctgatg   2760

agatcctggt ggtgaaacgt cttccaaaaa ccaggtctgg gaaggtcatg cggcggctcc   2820

tgaggaagat catcactagt gaggcccagg agctgggaga cactaccacc ttggaggacc   2880

ccagcatcat cgcagagatc ctgagtgtct accagaagtg caaggacaag caggctgctg   2940

ctaagtgagc tggcaccttg tggggctctt gggatgggcg ggcacccaag ccctggcttg   3000

tccttcccag aaggtacccc tgaggttggc gtcttcctac gtcccagaag cagcccccac   3060

cccacacatg acccacaccg ccctcacgtg aagctgggct gagagccctt tctcccatcc   3120

attggaggtc ccaggagtgt cacccatgga gaggctatgc gacatggcta gggctggttc   3180

tgccatctga gtttggtttc ctggaatgaa aaggcattgc catctccatt cctctgccct   3240

cttgagccag cacaggaagg tgaggccctg ggatagcgcg cctgctcaga taacacagag   3300

ctagttagct agtagcaacc gtgttttctc cagatctgtc tagatacaaa ggtcagaaat   3360

cttattttta tacttttata ttgtggaaga acagcatgca acactcacat gtagtgtgtg   3420

gatttacttg aacatgttct ttttaacatg tagttatgaa aatctccttt tttgcctcta   3480

ctggtgagga aacatgagga tcagaggcca catttttaat tattgttagt gtatttggaa   3540

gtctgaattg gagatgtttg tacctctgtc taaacagttc ccttgagaac ttccaagcct   3600

ccggcatctt ttcctggtga gtgtttctcc tgtgcttggt tgtgtataat ggagctaact   3660

cctaagcggt ggggtgaatg tggccgcctt agttctgaag ctactccagt tatgttctgt   3720

ttcttcaagc tgtgatccag aaagattttt gtgcccccag atgcctcttg ataggagagg   3780

caacatactc caaatagttg ggttcttcag ggaagctatt agaaactcag gtgacttgtt   3840

agagcactaa cttggtcaga gccaaatcct ggcaaacgct gcctgacctt cactctgtgg   3900

ttggggcggt gagaaccact gaggtccaat gatgagactt ggaggtctgg atccagtctc   3960

tctttgtttt aatgtgactt aggtgctgtc aacattagca agataatgga aatcacgacg   4020

ccagtgggtg cttacctccc tgctaggcat gcaggggctg gcggttggca ggggaaggag   4080

gcccagtgag ccgggtccct taggggaggg agagtttgtc ctctttgccc cacagtctac   4140

ccttcagggc cttgtggcag tgccagtgtt cggggggtgt ctgggccact gagtacccac   4200

tcggtcgtgg ttgtgctggc ctcttgggtg agtgaacctg tgaagcccag gaggtggtgt   4260

tggctgcagg gtacacaaat actgagtggt ggtcttttgt tacaggctta gcaacaaagc   4320

tgtgccctgg gcatgggggg ctgtagtgta gctacagttg tgcgtttgtg aaatggctta   4380

gctttccatg ttgctgagag gaacctggac atggtcccgg gcatctgaat gatctgtagg   4440

ggagggagtt caaataaagc tttattttgt tcaaaaaaaa aaaaaaaa                4488


<210>  3833
<211>  689
<212>  PRT
<213>  Homosapiens

<400>  3833

Met Ala Ala Arg Thr Leu Gly Arg Gly Val Gly Arg Leu Leu Gly Ser 
1               5                   10                  15      


Leu Arg Gly Leu Ser Gly Gln Pro Ala Arg Pro Pro Cys Gly Val Ser 
            20                  25                  30          


Ala Pro Arg Arg Ala Ala Ser Gly Pro Ser Gly Ser Ala Pro Ala Val 
        35                  40                  45              


Ala Ala Ala Ala Ala Gln Pro Gly Ser Tyr Pro Ala Leu Ser Ala Gln 
    50                  55                  60                  


Ala Ala Arg Glu Pro Ala Ala Phe Trp Gly Pro Leu Ala Arg Asp Thr 
65                  70                  75                  80  


Leu Val Trp Asp Thr Pro Tyr His Thr Val Trp Asp Cys Asp Phe Ser 
                85                  90                  95      


Thr Gly Lys Ile Gly Trp Phe Leu Gly Gly Gln Leu Asn Val Ser Val 
            100                 105                 110         


Asn Cys Leu Asp Gln His Val Arg Lys Ser Pro Glu Ser Val Ala Leu 
        115                 120                 125             


Ile Trp Glu Arg Asp Glu Pro Gly Thr Glu Val Arg Ile Thr Tyr Arg 
    130                 135                 140                 


Glu Leu Leu Glu Thr Thr Cys Arg Leu Ala Asn Thr Leu Lys Arg His 
145                 150                 155                 160 


Gly Val His Arg Gly Asp Arg Val Ala Ile Tyr Met Pro Val Ser Pro 
                165                 170                 175     


Leu Ala Val Ala Ala Met Leu Ala Cys Ala Arg Ile Gly Ala Val His 
            180                 185                 190         


Thr Val Ile Phe Ala Gly Phe Ser Ala Glu Ser Leu Ala Gly Arg Ile 
        195                 200                 205             


Asn Asp Ala Lys Cys Lys Val Val Ile Thr Phe Asn Gln Gly Leu Arg 
    210                 215                 220                 


Gly Gly Arg Val Val Glu Leu Lys Lys Ile Val Asp Glu Ala Val Lys 
225                 230                 235                 240 


His Cys Pro Thr Val Gln His Val Leu Val Ala His Arg Thr Asp Asn 
                245                 250                 255     


Lys Val His Met Gly Asp Leu Asp Val Pro Leu Glu Gln Glu Met Ala 
            260                 265                 270         


Lys Glu Asp Pro Val Cys Ala Pro Glu Ser Met Gly Ser Glu Asp Met 
        275                 280                 285             


Leu Phe Met Leu Tyr Thr Ser Gly Ser Thr Gly Met Pro Lys Gly Ile 
    290                 295                 300                 


Val His Thr Gln Ala Gly Tyr Leu Leu Tyr Ala Ala Leu Thr His Lys 
305                 310                 315                 320 


Leu Val Phe Asp His Gln Pro Gly Asp Ile Phe Gly Cys Val Ala Asp 
                325                 330                 335     


Ile Gly Trp Ile Thr Gly His Ser Tyr Val Val Tyr Gly Pro Leu Cys 
            340                 345                 350         


Asn Gly Ala Thr Ser Val Leu Phe Glu Ser Thr Pro Val Tyr Pro Asn 
        355                 360                 365             


Ala Gly Arg Tyr Trp Glu Thr Val Glu Arg Leu Lys Ile Asn Gln Phe 
    370                 375                 380                 


Tyr Gly Ala Pro Thr Ala Val Arg Leu Leu Leu Lys Tyr Gly Asp Ala 
385                 390                 395                 400 


Trp Val Lys Lys Tyr Asp Arg Ser Ser Leu Arg Thr Leu Gly Ser Val 
                405                 410                 415     


Gly Glu Pro Ile Asn Cys Glu Ala Trp Glu Trp Leu His Arg Val Val 
            420                 425                 430         


Gly Asp Ser Arg Cys Thr Leu Val Asp Thr Trp Trp Gln Thr Glu Thr 
        435                 440                 445             


Gly Gly Ile Cys Ile Ala Pro Arg Pro Ser Glu Glu Gly Ala Glu Ile 
    450                 455                 460                 


Leu Pro Ala Met Ala Met Arg Pro Phe Phe Gly Ile Val Pro Val Leu 
465                 470                 475                 480 


Met Asp Glu Lys Gly Ser Val Val Glu Gly Ser Asn Val Ser Gly Ala 
                485                 490                 495     


Leu Cys Ile Ser Gln Ala Trp Pro Gly Met Ala Arg Thr Ile Tyr Gly 
            500                 505                 510         


Asp His Gln Arg Phe Val Asp Ala Tyr Phe Lys Ala Tyr Pro Gly Tyr 
        515                 520                 525             


Tyr Phe Thr Gly Asp Gly Ala Tyr Arg Thr Glu Gly Gly Tyr Tyr Gln 
    530                 535                 540                 


Ile Thr Gly Arg Met Asp Asp Val Ile Asn Ile Ser Gly His Arg Leu 
545                 550                 555                 560 


Gly Thr Ala Glu Ile Glu Asp Ala Ile Ala Asp His Pro Ala Val Pro 
                565                 570                 575     


Glu Ser Ala Val Ile Gly Tyr Pro His Asp Ile Lys Gly Glu Ala Ala 
            580                 585                 590         


Phe Ala Phe Ile Val Val Lys Asp Ser Ala Gly Asp Ser Asp Val Val 
        595                 600                 605             


Val Gln Glu Leu Lys Ser Met Val Ala Thr Lys Ile Ala Lys Tyr Ala 
    610                 615                 620                 


Val Pro Asp Glu Ile Leu Val Val Lys Arg Leu Pro Lys Thr Arg Ser 
625                 630                 635                 640 


Gly Lys Val Met Arg Arg Leu Leu Arg Lys Ile Ile Thr Ser Glu Ala 
                645                 650                 655     


Gln Glu Leu Gly Asp Thr Thr Thr Leu Glu Asp Pro Ser Ile Ile Ala 
            660                 665                 670         


Glu Ile Leu Ser Val Tyr Gln Lys Cys Lys Asp Lys Gln Ala Ala Ala 
        675                 680                 685             


Lys 
    


<210>  3834
<211>  1956
<212>  DNA
<213>  Homosapiens

<400>  3834
tccagagagg ctcgcgcctt gcttgctaag gaaccatgac cggccgggac tcgctttccg     60

acgggcgcac tagcagcagg gcgctggtgc ctggcggttc ccctaggggc tcgcgccccc    120

ggggcttcgc catcacggac ctgctgggct tggaggccga gctgccggcg cccgctggcc    180

caggacaggg atctggctgc gagggtccgg cagtcgcgcc gtgcccgggc ccggggcttg    240

acggctccag cctggcgcgt ggggccctac cgctgggact cggcctcctc tgtggcttcg    300

gcacgcagcc gccggcggcc gctcgagcac cctgcctgct cctagcggac gtgccgttcc    360

tgccgcccag gggccccgag cccgctgccc cgctggctcc cagccgtccg ccgcctgcgc    420

tcggccgcca gaagcgcagc gacagcgtct ccacgtccga tgaggacagc cagtctgaag    480

acaggaatga cctaaaggca tcccccacct tgggcaagag gaagaagcgg cggcacagga    540

cagttttcac tgctcaccag ctggaagagt tggagaaggc attcagcgag gcccactacc    600

ctgatgtgta tgcccgagaa atgctggctg tgaaaactga gctccccgaa gaccggatac    660

aggtctggtt tcaaaaccgc agggccaaat ggcgcaagcg ggagaagcgc tggggcggca    720

gcagcgtgat ggccgagtac gggctgtacg gggccatggt gcgccactgc atcccgctgc    780

cagactccgt gctcaactcc gccgagggcg gcctgctggg ctcctgcgcg ccctggctcc    840

tggggatgca taaaaaatcc atggggatga taaggaagcc aggaagtgaa gataagttgg    900

caggactctg gggctctgac cacttcaaag aaggttctag ccagagtgag tcaggatcac    960

agagaggctc agataaagtg agccctgaga atggcttgga agatgtggct attgacctct   1020

ccagctctgc ccggcaggag accaagaaag tgcaccctgg ggctggtgct caaggaggct   1080

ccaactccac ggcactggag gggccccagc cagggaaggt gggagccaca tgagacccac   1140

aggtcccact gtcaaaggct gaaaatgtgc atattcctca ctggcatttt ccaaaagaca   1200

aaaattgtcc aagacatata ctctcagttt gattttcttc tgacaatgtc aagataaaat   1260

gcaatgccac ttgctttaag aggacagatg agtgacctag ggaaaattct atttcattct   1320

agaatggaaa cggttcctta atggcacttt aaccagttaa cttggtgcaa aacttttgat   1380

tctcttttgt agcttgagca gggaggatcc gaagttcaaa aatgatttca ctgctgggca   1440

tcatttgaga tgtgtggttc aatgtactgt atagatgaat aggttaggtc tgatgtcctc   1500

attctcaatt aggaaatata aaattgttta atatccagaa gaatctgata tcatcatagt   1560

gaagactcca tacagacaca tgaatgaatt atattgtctt taccttgaac ttggccttgg   1620

atatttcaat tttcttgtta gggagtaatt ttgtgttttc ttgagtgtca cttgataggc   1680

tatgcatatt ggaattcaaa gaaacccata ctctagtcgt ttctgcattt cctttaaaaa   1740

tagcatggga tcatatttaa acaattgttg gatagctgga aacagtgttt ttaggtcaga   1800

ccaggctttt ggtctttcaa aatttgtgat tgaaagcact ttagtgactt ggattttgta   1860

aatctttcct ttcctgcgtt tcctttgcca tttatttatt ctttaaaaat aaacattttg   1920

tggtgtgttt aaaaaaaaaa aaaaaaaaaa aaaaaa                             1956


<210>  3835
<211>  365
<212>  PRT
<213>  Homosapiens

<400>  3835

Met Thr Gly Arg Asp Ser Leu Ser Asp Gly Arg Thr Ser Ser Arg Ala 
1               5                   10                  15      


Leu Val Pro Gly Gly Ser Pro Arg Gly Ser Arg Pro Arg Gly Phe Ala 
            20                  25                  30          


Ile Thr Asp Leu Leu Gly Leu Glu Ala Glu Leu Pro Ala Pro Ala Gly 
        35                  40                  45              


Pro Gly Gln Gly Ser Gly Cys Glu Gly Pro Ala Val Ala Pro Cys Pro 
    50                  55                  60                  


Gly Pro Gly Leu Asp Gly Ser Ser Leu Ala Arg Gly Ala Leu Pro Leu 
65                  70                  75                  80  


Gly Leu Gly Leu Leu Cys Gly Phe Gly Thr Gln Pro Pro Ala Ala Ala 
                85                  90                  95      


Arg Ala Pro Cys Leu Leu Leu Ala Asp Val Pro Phe Leu Pro Pro Arg 
            100                 105                 110         


Gly Pro Glu Pro Ala Ala Pro Leu Ala Pro Ser Arg Pro Pro Pro Ala 
        115                 120                 125             


Leu Gly Arg Gln Lys Arg Ser Asp Ser Val Ser Thr Ser Asp Glu Asp 
    130                 135                 140                 


Ser Gln Ser Glu Asp Arg Asn Asp Leu Lys Ala Ser Pro Thr Leu Gly 
145                 150                 155                 160 


Lys Arg Lys Lys Arg Arg His Arg Thr Val Phe Thr Ala His Gln Leu 
                165                 170                 175     


Glu Glu Leu Glu Lys Ala Phe Ser Glu Ala His Tyr Pro Asp Val Tyr 
            180                 185                 190         


Ala Arg Glu Met Leu Ala Val Lys Thr Glu Leu Pro Glu Asp Arg Ile 
        195                 200                 205             


Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Trp Arg Lys Arg Glu Lys 
    210                 215                 220                 


Arg Trp Gly Gly Ser Ser Val Met Ala Glu Tyr Gly Leu Tyr Gly Ala 
225                 230                 235                 240 


Met Val Arg His Cys Ile Pro Leu Pro Asp Ser Val Leu Asn Ser Ala 
                245                 250                 255     


Glu Gly Gly Leu Leu Gly Ser Cys Ala Pro Trp Leu Leu Gly Met His 
            260                 265                 270         


Lys Lys Ser Met Gly Met Ile Arg Lys Pro Gly Ser Glu Asp Lys Leu 
        275                 280                 285             


Ala Gly Leu Trp Gly Ser Asp His Phe Lys Glu Gly Ser Ser Gln Ser 
    290                 295                 300                 


Glu Ser Gly Ser Gln Arg Gly Ser Asp Lys Val Ser Pro Glu Asn Gly 
305                 310                 315                 320 


Leu Glu Asp Val Ala Ile Asp Leu Ser Ser Ser Ala Arg Gln Glu Thr 
                325                 330                 335     


Lys Lys Val His Pro Gly Ala Gly Ala Gln Gly Gly Ser Asn Ser Thr 
            340                 345                 350         


Ala Leu Glu Gly Pro Gln Pro Gly Lys Val Gly Ala Thr 
        355                 360                 365 


<210>  3836
<211>  943
<212>  DNA
<213>  Homosapiens

<400>  3836
tccagagagg ctcgcgcctt gcttgctaag gaaccatgac cggccgggac tcgctttccg     60

acgggcgcac tagcagcagg gcgctggtgc ctggcggttc ccctaggggc tcgcgccccc    120

ggggcttcgc catcacggac ctgctgggct tggaggccga gctgccggcg cccgctggcc    180

caggacaggg atctggctgc gagggtccgg cagtcgcgcc gtgcccgggc ccggggcttg    240

acggctccag cctggcgcgt ggggccctac cgctgggact cggcctcctc tgtggcttcg    300

gcacgcagcc gccggcggcc gctcgagcac cctgcctgct cctagcggac gtgccgttcc    360

tgccgcccag gggccccgag cccgctgccc cgctggctcc cagccgtccg ccgcctgcgc    420

tcggccgcca gaagcgcagc gacagcgtct ccacgtccga tgaggacagc cagtctgaag    480

acaggaatga cctaaaggca tcccccacct tgggcaagag gaagaagcgg cggcacagga    540

cagttttcac tgctcaccag ctggaagagt tggagaaggc attcagcgag gcccactacc    600

ctgatgtgta tgcccgagaa atgctggctg tgaaaactga gctccccgaa gaccggatac    660

aggtgtctgg ggtccctttt ctccgctcca aagataccac agagaacgtg tcattcccac    720

attcagtgag ccaatcagca gtcccttctc tatagccaac acgctccctt tgcatagaaa    780

ctgagggtcc cttagctgaa ggcaccacaa gagcttgccc ctatgaccct catgcctttt    840

ttcattttat tattatttag tatcaaatca ttctttaaaa tcacatgata atgtgtgctg    900

caactagaaa ctataaagat atgtcaatga aaaaaaaaaa aaa                      943


<210>  3837
<211>  239
<212>  PRT
<213>  Homosapiens

<400>  3837

Met Thr Gly Arg Asp Ser Leu Ser Asp Gly Arg Thr Ser Ser Arg Ala 
1               5                   10                  15      


Leu Val Pro Gly Gly Ser Pro Arg Gly Ser Arg Pro Arg Gly Phe Ala 
            20                  25                  30          


Ile Thr Asp Leu Leu Gly Leu Glu Ala Glu Leu Pro Ala Pro Ala Gly 
        35                  40                  45              


Pro Gly Gln Gly Ser Gly Cys Glu Gly Pro Ala Val Ala Pro Cys Pro 
    50                  55                  60                  


Gly Pro Gly Leu Asp Gly Ser Ser Leu Ala Arg Gly Ala Leu Pro Leu 
65                  70                  75                  80  


Gly Leu Gly Leu Leu Cys Gly Phe Gly Thr Gln Pro Pro Ala Ala Ala 
                85                  90                  95      


Arg Ala Pro Cys Leu Leu Leu Ala Asp Val Pro Phe Leu Pro Pro Arg 
            100                 105                 110         


Gly Pro Glu Pro Ala Ala Pro Leu Ala Pro Ser Arg Pro Pro Pro Ala 
        115                 120                 125             


Leu Gly Arg Gln Lys Arg Ser Asp Ser Val Ser Thr Ser Asp Glu Asp 
    130                 135                 140                 


Ser Gln Ser Glu Asp Arg Asn Asp Leu Lys Ala Ser Pro Thr Leu Gly 
145                 150                 155                 160 


Lys Arg Lys Lys Arg Arg His Arg Thr Val Phe Thr Ala His Gln Leu 
                165                 170                 175     


Glu Glu Leu Glu Lys Ala Phe Ser Glu Ala His Tyr Pro Asp Val Tyr 
            180                 185                 190         


Ala Arg Glu Met Leu Ala Val Lys Thr Glu Leu Pro Glu Asp Arg Ile 
        195                 200                 205             


Gln Val Ser Gly Val Pro Phe Leu Arg Ser Lys Asp Thr Thr Glu Asn 
    210                 215                 220                 


Val Ser Phe Pro His Ser Val Ser Gln Ser Ala Val Pro Ser Leu 
225                 230                 235                 


<210>  3838
<211>  2762
<212>  DNA
<213>  Homosapiens

<400>  3838
gtggggtcgt atcccgcggg tggaggccgg ggtggcgccg gccggggcgg gggagcccaa     60

aagaccggct gccgcctgct ccccggaaaa gggcactcgt ctccgtgggt gtggcggagc    120

gcgcggtgca tggaatgggc tatgtgaatg aaaaaaggta tccgttatga aacttccaga    180

aaaacgagct acatttttca gcagccgcag cacggtcctt ggcaaacaag gatgagaaaa    240

atatccaacc acgggagcct gcgggtggcg aaggtggcat accccctggg gctgtgtgtg    300

ggcgtgttca tctatgttgc ctacatcaag tggcaccggg ccaccgccac ccaggccttc    360

ttcagcatca ccagggcagc cccgggggcc cggtggggtc agcaggccca cagccccctg    420

gggacagctg cagacgggca cgaggtcttc tacgggatca tgtttgatgc aggaagcact    480

ggcacccgag tacacgtctt ccagttcacc cggcccccca gagaaactcc cacgttaacc    540

cacgaaacct tcaaagcagt gaagccaggt ctttctgcct atgctgatga tgttgaaaag    600

agcgctcagg gaatccggga actactggat gttgctaaac aggacattcc gttcgacttc    660

tggaaggcca cccctctggt cctcaaggcc acagctggct tacgcctgtt acctggagaa    720

aaggcccaga agttactgca gaaggtgaaa gaagtattta aagcatcgcc tttccttgta    780

ggggatgact gtgtttccat catgaacgga acagatgaag gcgtttcggc gtggatcacc    840

atcaacttcc tgacaggcag cttgaaaact ccaggaggga gcagcgtggg catgctggac    900

ttgggcggag gatccactca gatcgccttc ctgccacgcg tggagggcac cctgcaggcc    960

tccccacccg gctacctgac ggcactgcgg atgtttaaca ggacctacaa gctctattcc   1020

tacagctacc tcgggctcgg gctgatgtcg gcacgcctgg cgatcctggg cggcgtggag   1080

gggcagcctg ctaaggatgg aaaggagttg gtcagccctt gcttgtctcc cagtttcaaa   1140

ggagagtggg aacacgcaga agtcacgtac agggtttcag ggcagaaagc agcggcaagc   1200

ctgcacgagc tgtgtgctgc cagagtgtca gaggtccttc aaaacagagt gcacaggacg   1260

gaggaagtga agcatgtgga cttctatgct ttctcctact attacgacct tgcagctggt   1320

gtgggcctca tagatgcgga gaagggaggc agcctggtgg tgggggactt cgagatcgca   1380

gccaagtacg tgtgtcggac cctggagaca cagccgcaga gcagcccctt ctcatgcatg   1440

gacctcacct acgtcagcct gctactccag gagttcggct ttcccaggag caaagtgctg   1500

aagctcactc ggaaaattga caatgttgag accagctggg ctctgggggc catttttcat   1560

tacatcgact ccctgaacag acagaagagt ccagcctcat agtggccgag ccatccctgt   1620

ccccgtcagc agtgtctgtg tgtctgcata aaccctcctg tcctggacgt gacttcatcc   1680

tgaggagcca cagcacaggc cgtgctggca ctttctgcac actggctctg ggacttgcag   1740

aaggcctggt gctgccctgg catcagcctc ttccagtcac atctggccag agggctgtct   1800

ggacctgggc cctgctcaat gccacctgtc tgcctgggct ccaagtgggc aggaccagga   1860

cagaaccaca ggcacacact gagggggcag tgtggctccc tgcctgtccc atccccatgc   1920

cccgtccgcg gggctgtggc tgctgctgtg catgtccctg cgatgggagt cttgtctccc   1980

agcctgtcag tttcctcccc agggcagagc tccccttcct gcaagagtct gggaggcggt   2040

gcaggctgtc ctggctgctc tggggaagcc gagggacagc cataacaccc ccgggacagt   2100

aggtctgggc ggcaccactg ggaactctgg acttgagtgt gtttgctctt ccttgggtat   2160

gaatgtgtga gttcacccag aggcctgctc tcctcacaca ttgtgtggtt tggggttaat   2220

gatggaggga gacacctctt catagacggc aggtgcccac ctttcaggga gtctcccagc   2280

atgggcggat gccgggcatg agctgctgta aactatttgt ggctgtgctg cttgagtgac   2340

gtctctgtcg tgtgggtgcc aagtgcttgt gtagaaactg tgttctgagc ccccttttct   2400

ggacaccaac tgtgtcctgt gaatgtatcg ctactgtgag ctgttcccgc ctagccaggg   2460

ccatgtctta ggtgcagctg tgccacgggt cagctgagcc acagtcccag aaccaagctc   2520

tcggtgtctc gggccaccat ccgcccacct cgggctgacc ccacctcctc catggacagt   2580

gtgagccccg ggccgtgcat cctgctcagt gtggcgtcag tgtcggggct gagccccttg   2640

agctgcttca gtgaatgtac agtgcccggc acgagctgaa cctcatgtgt tccactccca   2700

ataaaaggtt gacaggggct tctccttcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2760

aa                                                                  2762


<210>  3839
<211>  484
<212>  PRT
<213>  Homosapiens

<400>  3839

Met Lys Lys Gly Ile Arg Tyr Glu Thr Ser Arg Lys Thr Ser Tyr Ile 
1               5                   10                  15      


Phe Gln Gln Pro Gln His Gly Pro Trp Gln Thr Arg Met Arg Lys Ile 
            20                  25                  30          


Ser Asn His Gly Ser Leu Arg Val Ala Lys Val Ala Tyr Pro Leu Gly 
        35                  40                  45              


Leu Cys Val Gly Val Phe Ile Tyr Val Ala Tyr Ile Lys Trp His Arg 
    50                  55                  60                  


Ala Thr Ala Thr Gln Ala Phe Phe Ser Ile Thr Arg Ala Ala Pro Gly 
65                  70                  75                  80  


Ala Arg Trp Gly Gln Gln Ala His Ser Pro Leu Gly Thr Ala Ala Asp 
                85                  90                  95      


Gly His Glu Val Phe Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly 
            100                 105                 110         


Thr Arg Val His Val Phe Gln Phe Thr Arg Pro Pro Arg Glu Thr Pro 
        115                 120                 125             


Thr Leu Thr His Glu Thr Phe Lys Ala Val Lys Pro Gly Leu Ser Ala 
    130                 135                 140                 


Tyr Ala Asp Asp Val Glu Lys Ser Ala Gln Gly Ile Arg Glu Leu Leu 
145                 150                 155                 160 


Asp Val Ala Lys Gln Asp Ile Pro Phe Asp Phe Trp Lys Ala Thr Pro 
                165                 170                 175     


Leu Val Leu Lys Ala Thr Ala Gly Leu Arg Leu Leu Pro Gly Glu Lys 
            180                 185                 190         


Ala Gln Lys Leu Leu Gln Lys Val Lys Glu Val Phe Lys Ala Ser Pro 
        195                 200                 205             


Phe Leu Val Gly Asp Asp Cys Val Ser Ile Met Asn Gly Thr Asp Glu 
    210                 215                 220                 


Gly Val Ser Ala Trp Ile Thr Ile Asn Phe Leu Thr Gly Ser Leu Lys 
225                 230                 235                 240 


Thr Pro Gly Gly Ser Ser Val Gly Met Leu Asp Leu Gly Gly Gly Ser 
                245                 250                 255     


Thr Gln Ile Ala Phe Leu Pro Arg Val Glu Gly Thr Leu Gln Ala Ser 
            260                 265                 270         


Pro Pro Gly Tyr Leu Thr Ala Leu Arg Met Phe Asn Arg Thr Tyr Lys 
        275                 280                 285             


Leu Tyr Ser Tyr Ser Tyr Leu Gly Leu Gly Leu Met Ser Ala Arg Leu 
    290                 295                 300                 


Ala Ile Leu Gly Gly Val Glu Gly Gln Pro Ala Lys Asp Gly Lys Glu 
305                 310                 315                 320 


Leu Val Ser Pro Cys Leu Ser Pro Ser Phe Lys Gly Glu Trp Glu His 
                325                 330                 335     


Ala Glu Val Thr Tyr Arg Val Ser Gly Gln Lys Ala Ala Ala Ser Leu 
            340                 345                 350         


His Glu Leu Cys Ala Ala Arg Val Ser Glu Val Leu Gln Asn Arg Val 
        355                 360                 365             


His Arg Thr Glu Glu Val Lys His Val Asp Phe Tyr Ala Phe Ser Tyr 
    370                 375                 380                 


Tyr Tyr Asp Leu Ala Ala Gly Val Gly Leu Ile Asp Ala Glu Lys Gly 
385                 390                 395                 400 


Gly Ser Leu Val Val Gly Asp Phe Glu Ile Ala Ala Lys Tyr Val Cys 
                405                 410                 415     


Arg Thr Leu Glu Thr Gln Pro Gln Ser Ser Pro Phe Ser Cys Met Asp 
            420                 425                 430         


Leu Thr Tyr Val Ser Leu Leu Leu Gln Glu Phe Gly Phe Pro Arg Ser 
        435                 440                 445             


Lys Val Leu Lys Leu Thr Arg Lys Ile Asp Asn Val Glu Thr Ser Trp 
    450                 455                 460                 


Ala Leu Gly Ala Ile Phe His Tyr Ile Asp Ser Leu Asn Arg Gln Lys 
465                 470                 475                 480 


Ser Pro Ala Ser 
                


<210>  3840
<211>  4131
<212>  DNA
<213>  Homosapiens

<400>  3840
gcagtgccgg gcgccagagc agcggcgcca gagcagctgc accatcccgg cgttcgcgtg     60

tgccgccgct ttcctcctcc atctcttttc ctccgcctcc gccggcgcga tggcgaagcc    120

gctgacggac agcgagaagc ggaagcagat cagcgtgcgc ggcctggcgg ggctaggcga    180

cgtggccgag gtgcggaaga gcttcaaccg gcacttgcac ttcacgctgg tcaaggaccg    240

caatgtggcc acgccccgcg actacttctt cgcgctggcg cacacggtgc gcgaccacct    300

cgtgggccgc tggatccgca cgcagcagca ctactacgag cgcgacccca agcgcattta    360

ttatctttcc ctggaattct acatgggtcg cacgctgcag aacacgatgg tgaacctggg    420

ccttcagaat gcctgcgatg aagccatcta tcagttgggg ttagacttgg aggaactcga    480

ggagatagaa gaagatgctg gccttgggaa tggaggcctg gggaggctgg cagcgtgttt    540

ccttgactca atggctacct tgggcctggc agcatacggc tatggaatcc gctatgaatt    600

tgggattttt aaccagaaga ttgtcaatgg ctggcaggta gaggaggccg atgactggct    660

gcgctacggc aacccctggg agaaagcgcg gcctgagtat atgcttcccg tgcacttcta    720

cggacgcgtg gagcacaccc ccgacggcgt gaagtggctg gacacacagg tggtgctggc    780

catgccctac gacaccccag tgcccggcta caagaacaac accgtcaaca ccatgcggct    840

gtggtccgcc aaggctccca acgacttcaa gctgcaggac ttcaacgtgg gagactacat    900

cgaggcggtc ctggaccgga acttggctga gaacatctcc agggtcctgt atccaaatga    960

taacttcttt gaggggaagg agctgcggct gaagcaggag tacttcgtgg tggccgccac   1020

gctccaggac atcatccgcc gcttcaagtc gtccaagttc ggctgccggg accctgtgag   1080

aacctgtttc gagacgttcc cagacaaggt ggccatccag ctgaacgaca cccaccccgc   1140

cctctccatc cctgagctca tgcggatcct ggtggacgtg gagaaggtgg actgggacaa   1200

ggcctgggaa atcacgaaga agacctgtgc atacaccaac cacactgtgc tgcctgaggc   1260

cttggagcgc tggcccgtgt ccatgtttga gaagctgctg ccgcggcacc tggagataat   1320

ctatgccatc aaccagcggc acctggacca cgtggccgcg ctgtttcccg gcgatgtgga   1380

ccgcctgcgc aggatgtctg tgatcgagga gggggactgc aagcggatca acatggccca   1440

cctgtgtgtg attgggtccc atgctgtcaa tggtgtggcg aggatccact cggagatcgt   1500

gaaacagtcg gtctttaagg atttttatga actggagcca gagaagttcc agaataagac   1560

caatggcatc accccccgcc ggtggctgct gctgtgcaac ccggggctgg ccgataccat   1620

cgtggagaaa attggggagg agttcctgac tgacctgagc cagctgaaga agctgctgcc   1680

gctggtcagt gacgaggtgt tcatcaggga cgtggccaag gtcaaacagg agaacaagct   1740

caagttctcg gccttcctgg agaaggagta caaggtgaag atcaacccct cctccatgtt   1800

cgatgtgcat gtgaagagga tccacgagta caagcggcag ctgctcaact gcctgcacgt   1860

cgtcaccctg tacaatcgaa tcaagagaga cccggccaag gcttttgtgc ccaggactgt   1920

tatgattggg ggcaaggcag cgcccggtta ccacatggcc aagctgatca tcaagttggt   1980

cacctccatc ggcgacgtcg tcaatcatga cccagttgtg ggtgacaggt tgaaagtgat   2040

cttcctggag aactaccgtg tgtccttggc tgagaaagtg atcccggccg ctgatctgtc   2100

gcagcagatc tccactgcag gcaccgaggc ctcaggcaca ggcaacatga agttcatgct   2160

caacggggcc ctcaccatcg gcaccatgga cggcgccaac gtggagatgg ccgaggaggc   2220

cggggccgag aacctcttca tcttcggcct gcgggtggag gatgtcgagg ccttggaccg   2280

gaaagggtac aatgccaggg agtactacga ccacctgccc gagctgaagc aggccgtgga   2340

ccagatcagc agtggctttt tttctcccaa ggagccagac tgcttcaagg acatcgtgaa   2400

catgctgatg caccatgaca ggttcaaggt gtttgcagac tatgaagcct acatgcagtg   2460

ccaggcacag gtggaccagc tgtaccggaa ccccaaggag tggaccaaga aggtcatcag   2520

gaacatcgcc tgctcgggca agttctccag tgaccggacc atcacggagt atgcacggga   2580

gatctggggt gtggagccct ccgacctgca gatcccgccc cccaacatcc cccgggacta   2640

ggcacaccct gccttggcgg gaccagcggg catttgtttt cttgctgact ttgcacctcc   2700

ttttttcccc aaacactttg ccagccactg gtggtccctg cttttctgag taccatgttt   2760

ccaggagggg ccatgggggt cagggtggtt ttgagagagc agggtaagga aggaatgtgc   2820

tagaagtgct cctagtttct tgtaaaggaa gccagagttg acagtacaaa gggtcgtggc   2880

cagccctgca gcttcagcac ctgccccacc cagagtggga gtcaggtgga gccacctgct   2940

gggctccccc agaactttgc acacatcttg ctatgtatta gccgatgtct ttagtgttga   3000

gcctctggat tctggggtct gggccagtgg ccatagtgaa gcctgggaat gagtgttact   3060

gcagcatctg ggctgccagc cacagggaag ggccaagccc catgtagccc cagtcatcct   3120

gcccagccct gcctcctggc catgccggga ggggtcggat cctctaggca tcgccttcac   3180

agccccctgc cccctgccct ctgtcctggc tctgcacctg gtatatgggt catggaccca   3240

gatggggctt tccctttgta gccatccaat gggcattgtg tgggtgcttg gaacccggga   3300

tgactgaggg ggacactgga gtgggtgctt gtgtctgctg tctcagaggc cttggtcagg   3360

atgaagttgg ctgacacagc ttagcttggt tttgcttatt caaaagagaa aataactaca   3420

catggaaatg aaactagctg aagccttttc ttgttttagc aactgaaaat tgtacttggt   3480

cacttttgtg cttgaggagg cccattttct gcctggcagg gggcaggtct gtgccctccc   3540

gctgactcct gctgtgtcct gaggtgcatt tcctgttgta cacacaaggg ccaggctcca   3600

ttctccctcc ctttccacca gtgccacagc ctcgtctgga aaaaggacca ggggtcccgg   3660

aggaacccat ttgtgctctg cttggacagc aggcctggca ctgggaggtg ggggtgagcc   3720

cctcacagcc ttgcccctcc ccaaggctgg caacctgcct cccattgccc aagagagagg   3780

gcagggaaca ggctactgtc cttccctgtg gaattgccga gaaatctagc accttgcatg   3840

ctggatctgg gctgcgggga ggctcttttt ctccctggcc tccagtgccc accaggagga   3900

tctgcgcacg gtgcacagcc caccagagca ctacagcctt ttattgagtg gggcaagtgc   3960

tgggctgtgg tcgtgccctg acagcatctt ccccaggcag cggctctgtg gaggaggcca   4020

tactccccta gttggccact ggggccacca ccctgaccac cactgtgccc ctcattgtta   4080

ctgccttgtg agataaaaac tgattaaacc tttgtggctg tggttggctg a            4131


<210>  3841
<211>  843
<212>  PRT
<213>  Homosapiens

<400>  3841

Met Ala Lys Pro Leu Thr Asp Ser Glu Lys Arg Lys Gln Ile Ser Val 
1               5                   10                  15      


Arg Gly Leu Ala Gly Leu Gly Asp Val Ala Glu Val Arg Lys Ser Phe 
            20                  25                  30          


Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr 
        35                  40                  45              


Pro Arg Asp Tyr Phe Phe Ala Leu Ala His Thr Val Arg Asp His Leu 
    50                  55                  60                  


Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Glu Arg Asp Pro 
65                  70                  75                  80  


Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu 
                85                  90                  95      


Gln Asn Thr Met Val Asn Leu Gly Leu Gln Asn Ala Cys Asp Glu Ala 
            100                 105                 110         


Ile Tyr Gln Leu Gly Leu Asp Leu Glu Glu Leu Glu Glu Ile Glu Glu 
        115                 120                 125             


Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe 
    130                 135                 140                 


Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile 
145                 150                 155                 160 


Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Val Asn Gly Trp Gln 
                165                 170                 175     


Val Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys 
            180                 185                 190         


Ala Arg Pro Glu Tyr Met Leu Pro Val His Phe Tyr Gly Arg Val Glu 
        195                 200                 205             


His Thr Pro Asp Gly Val Lys Trp Leu Asp Thr Gln Val Val Leu Ala 
    210                 215                 220                 


Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Lys Asn Asn Thr Val Asn 
225                 230                 235                 240 


Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn Asp Phe Lys Leu Gln 
                245                 250                 255     


Asp Phe Asn Val Gly Asp Tyr Ile Glu Ala Val Leu Asp Arg Asn Leu 
            260                 265                 270         


Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu 
        275                 280                 285             


Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr 
    290                 295                 300                 


Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Phe Gly Cys Arg 
305                 310                 315                 320 


Asp Pro Val Arg Thr Cys Phe Glu Thr Phe Pro Asp Lys Val Ala Ile 
                325                 330                 335     


Gln Leu Asn Asp Thr His Pro Ala Leu Ser Ile Pro Glu Leu Met Arg 
            340                 345                 350         


Ile Leu Val Asp Val Glu Lys Val Asp Trp Asp Lys Ala Trp Glu Ile 
        355                 360                 365             


Thr Lys Lys Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala 
    370                 375                 380                 


Leu Glu Arg Trp Pro Val Ser Met Phe Glu Lys Leu Leu Pro Arg His 
385                 390                 395                 400 


Leu Glu Ile Ile Tyr Ala Ile Asn Gln Arg His Leu Asp His Val Ala 
                405                 410                 415     


Ala Leu Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Val Ile 
            420                 425                 430         


Glu Glu Gly Asp Cys Lys Arg Ile Asn Met Ala His Leu Cys Val Ile 
        435                 440                 445             


Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Val 
    450                 455                 460                 


Lys Gln Ser Val Phe Lys Asp Phe Tyr Glu Leu Glu Pro Glu Lys Phe 
465                 470                 475                 480 


Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Leu Leu Cys 
                485                 490                 495     


Asn Pro Gly Leu Ala Asp Thr Ile Val Glu Lys Ile Gly Glu Glu Phe 
            500                 505                 510         


Leu Thr Asp Leu Ser Gln Leu Lys Lys Leu Leu Pro Leu Val Ser Asp 
        515                 520                 525             


Glu Val Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu 
    530                 535                 540                 


Lys Phe Ser Ala Phe Leu Glu Lys Glu Tyr Lys Val Lys Ile Asn Pro 
545                 550                 555                 560 


Ser Ser Met Phe Asp Val His Val Lys Arg Ile His Glu Tyr Lys Arg 
                565                 570                 575     


Gln Leu Leu Asn Cys Leu His Val Val Thr Leu Tyr Asn Arg Ile Lys 
            580                 585                 590         


Arg Asp Pro Ala Lys Ala Phe Val Pro Arg Thr Val Met Ile Gly Gly 
        595                 600                 605             


Lys Ala Ala Pro Gly Tyr His Met Ala Lys Leu Ile Ile Lys Leu Val 
    610                 615                 620                 


Thr Ser Ile Gly Asp Val Val Asn His Asp Pro Val Val Gly Asp Arg 
625                 630                 635                 640 


Leu Lys Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys 
                645                 650                 655     


Val Ile Pro Ala Ala Asp Leu Ser Gln Gln Ile Ser Thr Ala Gly Thr 
            660                 665                 670         


Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu 
        675                 680                 685             


Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala 
    690                 695                 700                 


Gly Ala Glu Asn Leu Phe Ile Phe Gly Leu Arg Val Glu Asp Val Glu 
705                 710                 715                 720 


Ala Leu Asp Arg Lys Gly Tyr Asn Ala Arg Glu Tyr Tyr Asp His Leu 
                725                 730                 735     


Pro Glu Leu Lys Gln Ala Val Asp Gln Ile Ser Ser Gly Phe Phe Ser 
            740                 745                 750         


Pro Lys Glu Pro Asp Cys Phe Lys Asp Ile Val Asn Met Leu Met His 
        755                 760                 765             


His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Ala Tyr Met Gln Cys 
    770                 775                 780                 


Gln Ala Gln Val Asp Gln Leu Tyr Arg Asn Pro Lys Glu Trp Thr Lys 
785                 790                 795                 800 


Lys Val Ile Arg Asn Ile Ala Cys Ser Gly Lys Phe Ser Ser Asp Arg 
                805                 810                 815     


Thr Ile Thr Glu Tyr Ala Arg Glu Ile Trp Gly Val Glu Pro Ser Asp 
            820                 825                 830         


Leu Gln Ile Pro Pro Pro Asn Ile Pro Arg Asp 
        835                 840             


<210>  3842
<211>  1983
<212>  DNA
<213>  Homosapiens

<400>  3842
gccggcgcag cggcctgggc tgggatgtga ggagcggcgg gttccgggct ccgggctctg     60

ggtggcggcg gctgtgagcg gcggcactgc ggcgcaggcc agcgggcgcc gtcggcggct    120

ggccctgtcg gccgcgggat gaggaagcgg accgagcccg tcgccttgga gcatgagcgc    180

tgcgccgccg cgggctcgtc ctcctccggc tcggccgccg cggcgctgga cgccgactgc    240

cgcctgaagc agaacctacg cctgacgggc ccggcggcgg ctgagccgcg ctgcgcagcc    300

gacgcgggaa tgaagcgggc gctgggcagg cgaaagggcg tgtggttgcg cctgaggaag    360

atacttttct gtgttttggg gttgtacatt gccattccat ttctcatcaa actatgtcct    420

ggaatacagg ccaaactgat tttcttgaat ttcgtaagag ttccctattt cattgatttg    480

aaaaaaccac aggatcaagg tttgaatcac acgtgtaact actacctgca gccagaggaa    540

gacgtgacca ttggagtctg gcacaccgtc cctgcagtct ggtggaagaa cgcccaaggc    600

aaagaccaga tgtggtatga ggatgccttg gcttccagcc accctatcat tctgtacctg    660

catgggaacg caggtaccag aggaggcgac caccgcgtgg agctttacaa ggtgctgagt    720

tcccttggtt accatgtggt cacctttgac tacagaggtt ggggtgactc agtgggaacg    780

ccatctgagc ggggcatgac ctatgacgca ctccacgttt ttgactggat caaagcaaga    840

agtggtgaca accccgtgta catctggggc cactctctgg gcactggcgt ggcgacaaat    900

ctggtgcggc gcctctgtga gcgagagacg cctccagatg cccttatatt ggaatctcca    960

ttcactaata tccgcgaaga agctaagagc catccatttt cagtgatata tcgatacttc   1020

cctgggtttg actggttctt ccttgatcct attacaagta gtggaattaa atttgcaaat   1080

gatgaaaacg tgaagcacat ctcctgtccc ctgctcatcc tgcacgctga ggacgacccg   1140

gtggtgccct tccagcttgg cagaaagctc tatagcatcg ccgcaccagc tcgaagcttc   1200

cgagatttca aagttcagtt tgtgcccttt cattcagacc ttggctacag gcacaaatac   1260

atttacaaga gccctgagct gccacggata ctgagggaat tcctggggaa gtcggagcct   1320

gagcaccagc actgagcctg gccgtgggaa ggaagcatga agacctctgc cctcctcccg   1380

ttttcctcca gtcagcagcc cggtatcctg aagccccggg gggccggcac ctgcaatgct   1440

caggagccca gctcgcacct ggagagcacc tcagatccca ggcggggagg cccctgcagg   1500

cctgcagtgc ccggaggcct gagcatggct gtgtggaaag cgtgggtggc aggcatgtgg   1560

ctctccttgc cgcccctcaa cctgagatct tgttgggaga cttaatggca gcaggcagcc   1620

atcactgcct gcttgatgct gcactgagct ggacaggggg agtccgggca ggggactctt   1680

ggggctcggg accatgctga gctttttggc accacccaca gagaacgtgg ggtccaggtt   1740

ctttctgcac cttcccagca catgcagaat gactccagtg gttccatcgt cccctcctgc   1800

cctgtgtacc tgcttgcctt tctcagctgc cccacctccc ctgggctggc ccactcaccc   1860

acagtggaag tgcccgggat ctgcacttcc tcccctttca cctacctgta cacctaacct   1920

ggccttagac tgagctttat ttaagaataa aatcgtggtg gtggtcaaaa aaaaaaaaaa   1980

aaa                                                                 1983


<210>  3843
<211>  398
<212>  PRT
<213>  Homosapiens

<400>  3843

Met Arg Lys Arg Thr Glu Pro Val Ala Leu Glu His Glu Arg Cys Ala 
1               5                   10                  15      


Ala Ala Gly Ser Ser Ser Ser Gly Ser Ala Ala Ala Ala Leu Asp Ala 
            20                  25                  30          


Asp Cys Arg Leu Lys Gln Asn Leu Arg Leu Thr Gly Pro Ala Ala Ala 
        35                  40                  45              


Glu Pro Arg Cys Ala Ala Asp Ala Gly Met Lys Arg Ala Leu Gly Arg 
    50                  55                  60                  


Arg Lys Gly Val Trp Leu Arg Leu Arg Lys Ile Leu Phe Cys Val Leu 
65                  70                  75                  80  


Gly Leu Tyr Ile Ala Ile Pro Phe Leu Ile Lys Leu Cys Pro Gly Ile 
                85                  90                  95      


Gln Ala Lys Leu Ile Phe Leu Asn Phe Val Arg Val Pro Tyr Phe Ile 
            100                 105                 110         


Asp Leu Lys Lys Pro Gln Asp Gln Gly Leu Asn His Thr Cys Asn Tyr 
        115                 120                 125             


Tyr Leu Gln Pro Glu Glu Asp Val Thr Ile Gly Val Trp His Thr Val 
    130                 135                 140                 


Pro Ala Val Trp Trp Lys Asn Ala Gln Gly Lys Asp Gln Met Trp Tyr 
145                 150                 155                 160 


Glu Asp Ala Leu Ala Ser Ser His Pro Ile Ile Leu Tyr Leu His Gly 
                165                 170                 175     


Asn Ala Gly Thr Arg Gly Gly Asp His Arg Val Glu Leu Tyr Lys Val 
            180                 185                 190         


Leu Ser Ser Leu Gly Tyr His Val Val Thr Phe Asp Tyr Arg Gly Trp 
        195                 200                 205             


Gly Asp Ser Val Gly Thr Pro Ser Glu Arg Gly Met Thr Tyr Asp Ala 
    210                 215                 220                 


Leu His Val Phe Asp Trp Ile Lys Ala Arg Ser Gly Asp Asn Pro Val 
225                 230                 235                 240 


Tyr Ile Trp Gly His Ser Leu Gly Thr Gly Val Ala Thr Asn Leu Val 
                245                 250                 255     


Arg Arg Leu Cys Glu Arg Glu Thr Pro Pro Asp Ala Leu Ile Leu Glu 
            260                 265                 270         


Ser Pro Phe Thr Asn Ile Arg Glu Glu Ala Lys Ser His Pro Phe Ser 
        275                 280                 285             


Val Ile Tyr Arg Tyr Phe Pro Gly Phe Asp Trp Phe Phe Leu Asp Pro 
    290                 295                 300                 


Ile Thr Ser Ser Gly Ile Lys Phe Ala Asn Asp Glu Asn Val Lys His 
305                 310                 315                 320 


Ile Ser Cys Pro Leu Leu Ile Leu His Ala Glu Asp Asp Pro Val Val 
                325                 330                 335     


Pro Phe Gln Leu Gly Arg Lys Leu Tyr Ser Ile Ala Ala Pro Ala Arg 
            340                 345                 350         


Ser Phe Arg Asp Phe Lys Val Gln Phe Val Pro Phe His Ser Asp Leu 
        355                 360                 365             


Gly Tyr Arg His Lys Tyr Ile Tyr Lys Ser Pro Glu Leu Pro Arg Ile 
    370                 375                 380                 


Leu Arg Glu Phe Leu Gly Lys Ser Glu Pro Glu His Gln His 
385                 390                 395             


<210>  3844
<211>  1610
<212>  DNA
<213>  Homosapiens

<400>  3844
gccggcgcag cggcctgggc tgggatgtga ggagcggcgg gttccgggct ccgggctctg     60

ggtggcggcg gctgtgagcg gcggcactgc ggcgcaggcc agcgggcgcc gtcggcggct    120

ggccctgtcg gccgcgggat gaggaagcgg accgagcccg tcgccttgga gcatgagcgc    180

tgcgccgccg cgggctcgtc ctcctccggc tcggccgccg cggcgctgga cgccgactgc    240

cgcctgaagc agaacctacg cctgacgggc ccggcggcgg ctgagccgcg ctgcgcagcc    300

gacgcgggaa tgaagcgggc gctgggcagg cgaaagggcg tgtggttgcg cctgaggaag    360

atacttttct gtgttttggg gttgtacatt gccattccat ttctcatcaa actatgtcct    420

ggaatacagg ccaaactgat tttcttgaat ttcgtaagag ttccctattt cattgatttg    480

aaaaaaccac aggatcaagg tttgaatcac acgtgtaact actacctgca gccagaggaa    540

gacgtgacca ttggagtctg gcacaccgtc cctgcagtct ggtggaagaa cgcccaaggc    600

aaagaccaga tgtggtatga ggatgccttg gcttccagcc accctatcat tctgtacctg    660

catgggaacg caggtaccag aggaggcgac caccgcgtgg agctttacaa ggtgctgagt    720

tcccttggtt accatgtggt cacctttgac tacagaggtt ggggtgactc agtgggaacg    780

ccatctgagc ggggcatgac ctatgacgca ctccacgttt ttgactggat caaagcaaga    840

agtggtgaca accccgtgta catctggggc cactctctgg gcactggcgt ggcgacaaat    900

ctggtgcggc gcctctgtga gcgagagacg cctccagatg cccttatatt ggaatctcca    960

ttcactaata tccgcgaaga agctaagagc catccatttt cagtgatata tcgatacttc   1020

cctgggtttg actggttctt ccttgatcct attacaagta gtggaattaa atttgcaaat   1080

gatgaaaacg tgaagcacat ctcctgtccc ctgctcatcc tgcacgctga ggacgacccg   1140

gtggtgccct tccagcttgg cagaaagctc tatagcatcg ccgcaccagc tcgaagcttc   1200

cgagatttca aagttcagtt tgtgcccttt cattcagacc ttggctacag gcacaaatac   1260

atttacaaga gccctgagct gccacggata ctgagacctc agcagggccc aggttccagc   1320

ccagatccca gcatgtggtc agagctggtg tgactgaagc caacaggtga cacggtcatc   1380

gaagagcagc agacaaaact aaaactaacc caaaggcagc tgaaagtgga gggcaggtga   1440

attcccagcc ctcgccggat tcaacttttg ccaacggtga agaactgccc tgagctgcaa   1500

accttacaaa gtctgtaact ctagataaac cataccatgt gctaactgca ctgaaataaa   1560

acactaacta cattataatg tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa              1610


<210>  3845
<211>  404
<212>  PRT
<213>  Homosapiens

<400>  3845

Met Arg Lys Arg Thr Glu Pro Val Ala Leu Glu His Glu Arg Cys Ala 
1               5                   10                  15      


Ala Ala Gly Ser Ser Ser Ser Gly Ser Ala Ala Ala Ala Leu Asp Ala 
            20                  25                  30          


Asp Cys Arg Leu Lys Gln Asn Leu Arg Leu Thr Gly Pro Ala Ala Ala 
        35                  40                  45              


Glu Pro Arg Cys Ala Ala Asp Ala Gly Met Lys Arg Ala Leu Gly Arg 
    50                  55                  60                  


Arg Lys Gly Val Trp Leu Arg Leu Arg Lys Ile Leu Phe Cys Val Leu 
65                  70                  75                  80  


Gly Leu Tyr Ile Ala Ile Pro Phe Leu Ile Lys Leu Cys Pro Gly Ile 
                85                  90                  95      


Gln Ala Lys Leu Ile Phe Leu Asn Phe Val Arg Val Pro Tyr Phe Ile 
            100                 105                 110         


Asp Leu Lys Lys Pro Gln Asp Gln Gly Leu Asn His Thr Cys Asn Tyr 
        115                 120                 125             


Tyr Leu Gln Pro Glu Glu Asp Val Thr Ile Gly Val Trp His Thr Val 
    130                 135                 140                 


Pro Ala Val Trp Trp Lys Asn Ala Gln Gly Lys Asp Gln Met Trp Tyr 
145                 150                 155                 160 


Glu Asp Ala Leu Ala Ser Ser His Pro Ile Ile Leu Tyr Leu His Gly 
                165                 170                 175     


Asn Ala Gly Thr Arg Gly Gly Asp His Arg Val Glu Leu Tyr Lys Val 
            180                 185                 190         


Leu Ser Ser Leu Gly Tyr His Val Val Thr Phe Asp Tyr Arg Gly Trp 
        195                 200                 205             


Gly Asp Ser Val Gly Thr Pro Ser Glu Arg Gly Met Thr Tyr Asp Ala 
    210                 215                 220                 


Leu His Val Phe Asp Trp Ile Lys Ala Arg Ser Gly Asp Asn Pro Val 
225                 230                 235                 240 


Tyr Ile Trp Gly His Ser Leu Gly Thr Gly Val Ala Thr Asn Leu Val 
                245                 250                 255     


Arg Arg Leu Cys Glu Arg Glu Thr Pro Pro Asp Ala Leu Ile Leu Glu 
            260                 265                 270         


Ser Pro Phe Thr Asn Ile Arg Glu Glu Ala Lys Ser His Pro Phe Ser 
        275                 280                 285             


Val Ile Tyr Arg Tyr Phe Pro Gly Phe Asp Trp Phe Phe Leu Asp Pro 
    290                 295                 300                 


Ile Thr Ser Ser Gly Ile Lys Phe Ala Asn Asp Glu Asn Val Lys His 
305                 310                 315                 320 


Ile Ser Cys Pro Leu Leu Ile Leu His Ala Glu Asp Asp Pro Val Val 
                325                 330                 335     


Pro Phe Gln Leu Gly Arg Lys Leu Tyr Ser Ile Ala Ala Pro Ala Arg 
            340                 345                 350         


Ser Phe Arg Asp Phe Lys Val Gln Phe Val Pro Phe His Ser Asp Leu 
        355                 360                 365             


Gly Tyr Arg His Lys Tyr Ile Tyr Lys Ser Pro Glu Leu Pro Arg Ile 
    370                 375                 380                 


Leu Arg Pro Gln Gln Gly Pro Gly Ser Ser Pro Asp Pro Ser Met Trp 
385                 390                 395                 400 


Ser Glu Leu Val 
                


<210>  3846
<211>  1861
<212>  DNA
<213>  Homosapiens

<400>  3846
gggagcgcgg agcggaggcc gaggcgagag cctggcgctg taggactaga acgaaaggag     60

tgaggcgccg agagcccaga taccattttg gcgtgagagc tggtggttgg caaggccgcg    120

ggagtgggaa gcgtccgcca tgttctgcga aaaagccatg gaactgatcc gcgagctgca    180

tcgcgcgccc gaagggcaac tgcctgcctt caacgaggat ggactcagac aagttctgga    240

ggagatgaaa gctttgtatg aacaaaacca gtctgatgtg aatgaagcaa agtcaggtgg    300

acgaagtgat ttgataccaa ctatcaaatt tcgacactgt tctctgttaa gaaatcgacg    360

ctgcactgta gcatacctgt atgaccgctt gcttcggatc agagcactca gatgggaata    420

tggtagcatc ttgccaaatg cattacgatt tcacatggct gctgaagaaa tggagtggtt    480

taataattat aaaagatctc ttgctactta tatgaggtca ctgggaggag atgaaggttt    540

ggacattaca caggatatga aaccaccaaa aagcctatat attgaagtcc ggtgtctaaa    600

agactatgga gaatttgaag ttgatgatgg cacttcagtc ctattaaaaa aaaatagcca    660

gcacttttta cctcgatgga aatgtgagca gctgatcaga caaggagtcc tggagcacat    720

cctgtcatga ccatgcgccg aggcacttcc aggcttcact caactcatgg actcctctgt    780

actcactctc tccaccactc ccttcacctc cctctttgat tttagaagct atagacattg    840

tttaagataa ctaagaatac ttggctaaga agtataattt gctaactatt aaggactttc    900

tttttttaat gttgtacact attcttccta ctcttttttg gttttggttt tgttttgtag    960

agactgtctc actatgttgc ccaagctggt ctcaaactcc tggcctcaag cagtcctccc   1020

accttagctt ctcaaagtgt tgagatcaca ggcgtgagcc actgcacccg gcccctactc   1080

ctttttctaa taagctgtat ctgtaatcac agcattccta cagttgttac agtgtgtttt   1140

ttaaatgaaa gtaaacatgg ttacatttga atctcttaaa taagcagtca cttggctgga   1200

caggaagaag gtagatcctg tgtgtcttgt tttctggtca tgtgtattgt acaagctaga   1260

gagctgaatt tctgagatac acattttcaa atcacatgca agtgaagatg atggtctgta   1320

gaaattttca gtatatataa tgtttaatga catactaatt tatcatctgg ctatttggga   1380

aggaaggaca cacatggatt ttgcacattt ccaccatggt ggctggtgtg gcttgtggct   1440

atggggtgat caccagtatc accactttgg aaggggacag tgaaattggg gctagagaag   1500

gaactttgta cagttttccc tgagattcag attgactgaa aagtcacatg aagagttgat   1560

tgtcttttaa tggtatgttt taaacagctg acattttaaa ttttgatgaa atccagttta   1620

ttcgtttgtt cttttatgct ttgggtgttg catccgagaa atcttttccc atcccaagat   1680

cacaattttt tttccttttt acttctagaa gtgttataat tttaagcttt atactttggt   1740

ctatgacccg tttttttttt tgttttgttt tgttttttcg tttgtttctt tgttttgaga   1800

tggagcctgg gtgatagagt gagacactgt cttgccaaaa aaaaaaaaaa aaaaaaaaaa   1860

a                                                                   1861


<210>  3847
<211>  196
<212>  PRT
<213>  Homosapiens

<400>  3847

Met Phe Cys Glu Lys Ala Met Glu Leu Ile Arg Glu Leu His Arg Ala 
1               5                   10                  15      


Pro Glu Gly Gln Leu Pro Ala Phe Asn Glu Asp Gly Leu Arg Gln Val 
            20                  25                  30          


Leu Glu Glu Met Lys Ala Leu Tyr Glu Gln Asn Gln Ser Asp Val Asn 
        35                  40                  45              


Glu Ala Lys Ser Gly Gly Arg Ser Asp Leu Ile Pro Thr Ile Lys Phe 
    50                  55                  60                  


Arg His Cys Ser Leu Leu Arg Asn Arg Arg Cys Thr Val Ala Tyr Leu 
65                  70                  75                  80  


Tyr Asp Arg Leu Leu Arg Ile Arg Ala Leu Arg Trp Glu Tyr Gly Ser 
                85                  90                  95      


Ile Leu Pro Asn Ala Leu Arg Phe His Met Ala Ala Glu Glu Met Glu 
            100                 105                 110         


Trp Phe Asn Asn Tyr Lys Arg Ser Leu Ala Thr Tyr Met Arg Ser Leu 
        115                 120                 125             


Gly Gly Asp Glu Gly Leu Asp Ile Thr Gln Asp Met Lys Pro Pro Lys 
    130                 135                 140                 


Ser Leu Tyr Ile Glu Val Arg Cys Leu Lys Asp Tyr Gly Glu Phe Glu 
145                 150                 155                 160 


Val Asp Asp Gly Thr Ser Val Leu Leu Lys Lys Asn Ser Gln His Phe 
                165                 170                 175     


Leu Pro Arg Trp Lys Cys Glu Gln Leu Ile Arg Gln Gly Val Leu Glu 
            180                 185                 190         


His Ile Leu Ser 
        195     


<210>  3848
<211>  4979
<212>  DNA
<213>  Homosapiens

<400>  3848
gcggtacggg ggtggtgccg cgctcctggc cccgcgcggg cggacggcgg aggcgcctcc     60

cagcctgcta tgggatggat gaagaagaga accactatgt ctcgcagctc agggaagtct    120

acagcagctg cgacaccacg gggactggct ttctggaccg ccaggagctg acccagctct    180

gccttaagct tcacctggag cagcagctgc ccgtcctcct gcagacgctt ctcggaaacg    240

accatttcgc cagggttaac tttgaggaat ttaaggaagg ttttgtggct gtgttgtctt    300

caaatgctgg tgttcgcccc tcagatgaag acagtagttc tttggaatca gctgcctcca    360

gtgccatccc tccaaagtat gtgaatggtt ctaagtggta tggccgtcgg agccggcctg    420

agctatgtga cgctgccaca gaagccagac gcgtgccgga gcagcaaacc caggccagcc    480

tgaaaagtca cctctggcgc tcagcgtctc tggagagcgt ggagagtccc aagtcagatg    540

aagaggccga gagcactaaa gaagctcaga atgaattatt tgaagcacaa ggacagctgc    600

agacctggga ttctgaggac tttgggagcc cccagaagtc ctgcagcccc tcctttgaca    660

ccccagagag ccagatccgg ggcgtgtggg aagagctggg ggtgggcagc agcggacacc    720

tgagcgagca ggagctggct gtggtctgcc agagcgtcgg gctccaggga ctcgagaaag    780

aggaactcga agacctgttt aacaaactgg atcaagacgg agacggcaaa gtgagtcttg    840

aggaattcca gcttggcctc ttcagtcatg agcccgcgct acttctagag tcttccactc    900

gggttaaacc gagcaaggct tggtctcatt accaggtccc agaggagagc ggctgccaca    960

ccaccacaac ctcatccctc gtgtccctgt gctccagcct gcgcctcttc tccagcattg   1020

acgatggttc tggcttcgct tttcctgatc aggtcctggc catgtggacc caggagggga   1080

ttcagaatgg cagggagatc ttgcagagcc tggacttcag cgtggacgag aaggtgaacc   1140

ttctggagct gacctgggcc cttgacaacg agctcatgac agtggacagt gccgtccagc   1200

aggcagccct ggcctgctac caccaggagc tgagctacca gcaagggcag gtggagcagc   1260

tggcaaggga gcgtgacaag gcaaggcagg acctggagag ggccgagaag aggaacctgg   1320

agtttgtgaa agagatggac gactgccact ccaccctgga gcagctcacg gagaagaaaa   1380

tcaagcatct ggagcagggg taccgggaaa ggctgagcct cctgcggtct gaggtggagg   1440

cggagcgaga gctgttctgg gagcaggccc acaggcagag ggccgcgctg gagtgggacg   1500

tggggcgcct gcaggctgag gaggctggcc tccgcgagaa gctgaccctg gccctgaagg   1560

aaaacagtcg cctacagaag gagattgtgg aagtggtgga aaagctttcg gattcggaga   1620

ggctggccct gaagctgcag aaggacctgg agtttgtgct gaaggacaag ctggagccac   1680

agagtgcaga gctcctggcc caggaggagc ggttcgcagc agtcctgaag gaatacgagc   1740

tcaagtgccg ggacctgcag gaccgcaacg atgagctgca agctgagctg gaaggcctgt   1800

gggcgcggct gcccaagaac cggcacagcc cctcatggag cccggatggg cgcagacggc   1860

agctccctgg actcggccca gcaggcattt cattcctggg taattctgct ccagtgagta   1920

tagaaacgga gctgatgatg gagcaggtaa aggagcatta ccaagacctc aggacccagc   1980

tggagaccaa ggtaaattac tacgaaaggg aaattgcggc actgaaaagg aactttgaga   2040

aggagaggaa ggacatggag caggctcgca ggcgcgaggt cagcgtgctg gagggtcaga   2100

aggccgacct ggaggagctc cacgagaagt ctcaggaggt catctggggc ctgcaggagc   2160

agctgcagga cacagcccgc ggccccgagc ctgagcagat gggcctggca ccctgctgca   2220

cccaggcact gtgtggcctg gccctgcggc atcacagcca cctgcagcag atcaggagag   2280

aggctgaggc ggagctgagt ggagagctgt cggggctggg agccctgccc gctcgcagag   2340

acctgacctt ggagctggag gagccgccgc agggacccct gccacgcggg agccagaggt   2400

cggagcagct ggagctggag agggcactga agctgcagcc ctgtgcgagc gagaagcgcg   2460

cccagatgtg cgtatcgttg gccctcgagg aggaggagtt ggagcttgcc cgcgggaagc   2520

gagtggacgg gccctccctg gaagcagaga tgcaggccct gccgaaagat gggctggtgg   2580

caggaagtgg ccaggagggc acacgtggcc tcctaccact gcgtccgggc tgtggggagc   2640

ggccactggc ctggctggcc ccaggtgatg gcagagagtc tgaggaggcg gcaggagccg   2700

ggcctcgccg caggcaagcc caggacacag aagctacgca gagcccggcc cccgcccctg   2760

ccccggcatc ccacggcccc tcagagaggt ggtcacgcat gcagccctgt ggagtggatg   2820

gggatattgt cccaaaggag ccagagcctt tcggcgcgag cgcagcgggg ctggagcagc   2880

ctggagcccg ggagctgcct ctgctgggaa cagagagaga cgcctcgcaa acccagccac   2940

ggatgtggga gccacccctg aggccggccg cttcgtgcag gggacaggct gagaggctac   3000

aggccattca ggaagagcga gcacgaagct ggagcagggg cacccaggag caggcctcgg   3060

agcagcaggc ccgggccgag ggcgccctgg agcctgggtg tcacaagcac agtgtggagg   3120

ttgccaggag agggtccttg ccatcccacc tccagctcgc agacccgcag ggttcctggc   3180

aggagcagct tgctgcccca gaagaggggg agaccaaaat agcgctggag agagagaagg   3240

atgacatgga aaccaaactt ctacatctgg aagacgtcgt ccgggctctg gagaaacatg   3300

tagatttgag agagaacgac agactggagt tccatagact ttctgaagaa aacactttgt   3360

tgaaaaacga tctgggaagg gttcggcaag agcttgaagc tgcagaaagt actcacgatg   3420

cacagaggaa ggaaattgag gttttaaaga aagacaagga aaaggcctgc tctgagatgg   3480

aggtgctcaa cagacagaat cagaactaca aggatcaatt atcccagctc aatgtcaggg   3540

ttcttcaact gggacaggag gcttctaccc accaggccca aaacgaggag catcgtgtga   3600

ccattcagat gttaacacag agcctggagg aggtggttcg cagtgggcag cagcagagtg   3660

accaaatcca aaaacttaga gttgaacttg aatgcctgaa tcaggaacat cagagcctgc   3720

agctgccatg gtcagagctg acccagaccc ttgaggaaag tcaagaccag gtgcagggag   3780

ctcacctgag gctgaggcag gcccaggccc agcacttgca ggaggtccgg ctggtgcccc   3840

aggaccgtgt ggccgagctg catcgcctgc tcagccttca gggagagcag gccaggaggc   3900

gcctggatgc acagcgggaa gaacatgaga aacagctgaa agccacagaa gagcgggtgg   3960

aagaggcgga gatgattctg aagaatatgg aaatgctcct ccaagagaaa gtggataagc   4020

tgaaggagca gtttgaaaag aacacgaagt ccgacctgct gctgaaggag ctgtacgtgg   4080

agaacgccca cctggtgaga gcacttcagg ccaccgagga gaagcagcga ggcgccgaga   4140

aacaaagccg cctcttggaa gaaaaagttc gcgctctcaa caaactcgtc agtaggattg   4200

cccccgcagc cctctctgtg taaagacaga ttattttcta ggattcattc gaaagcacat   4260

cttttaaatt aagccactgt gctgccttag attccgtggg tcatgagcca tgagtcctgg   4320

gacatctgag gattgggatt ctttgttcac cccgcagata gttaatgaat ggtctgccct   4380

gggcaagatg gaggtggggg ctgggggaat atgcatgttg cagaagccgg cgtttttatt   4440

agcggtcctg agtaatttcc cttggcaaaa ttcccagttt tgccactctc tggagccaga   4500

tcctgggagc tgtcagcaag gagcaggtaa gtgagcagtt atggacagca ctttccatgt   4560

ggtgcttccg accctggctg tcagagtgaa atgtaaagtc agggctctgt acagttttgc   4620

catttcactg ttctgcttta agcttagctt attagaactc ttggtggagg gtgcgtacac   4680

acattccaga aaaggcttca ctcgctggga acgtcaaccc agcgagaaag gaggggaagc   4740

cccttctccg gggaccttat ctgtggactc aggaatgatg gtgtttattg caaatgcaca   4800

atctttttcc cattgaaatg tcatcacact ggaaattgta ctatatgtaa aaaaaaaaaa   4860

aagtatagtt ttatatttga aatgtatgca aattatggcc atatggctga ttggaatgta   4920

ctactgtaat ataaaaagtc actgtatttg caataaattc ttttctatta aaaaaaaaa    4979


<210>  3849
<211>  1382
<212>  PRT
<213>  Homosapiens

<400>  3849

Met Asp Glu Glu Glu Asn His Tyr Val Ser Gln Leu Arg Glu Val Tyr 
1               5                   10                  15      


Ser Ser Cys Asp Thr Thr Gly Thr Gly Phe Leu Asp Arg Gln Glu Leu 
            20                  25                  30          


Thr Gln Leu Cys Leu Lys Leu His Leu Glu Gln Gln Leu Pro Val Leu 
        35                  40                  45              


Leu Gln Thr Leu Leu Gly Asn Asp His Phe Ala Arg Val Asn Phe Glu 
    50                  55                  60                  


Glu Phe Lys Glu Gly Phe Val Ala Val Leu Ser Ser Asn Ala Gly Val 
65                  70                  75                  80  


Arg Pro Ser Asp Glu Asp Ser Ser Ser Leu Glu Ser Ala Ala Ser Ser 
                85                  90                  95      


Ala Ile Pro Pro Lys Tyr Val Asn Gly Ser Lys Trp Tyr Gly Arg Arg 
            100                 105                 110         


Ser Arg Pro Glu Leu Cys Asp Ala Ala Thr Glu Ala Arg Arg Val Pro 
        115                 120                 125             


Glu Gln Gln Thr Gln Ala Ser Leu Lys Ser His Leu Trp Arg Ser Ala 
    130                 135                 140                 


Ser Leu Glu Ser Val Glu Ser Pro Lys Ser Asp Glu Glu Ala Glu Ser 
145                 150                 155                 160 


Thr Lys Glu Ala Gln Asn Glu Leu Phe Glu Ala Gln Gly Gln Leu Gln 
                165                 170                 175     


Thr Trp Asp Ser Glu Asp Phe Gly Ser Pro Gln Lys Ser Cys Ser Pro 
            180                 185                 190         


Ser Phe Asp Thr Pro Glu Ser Gln Ile Arg Gly Val Trp Glu Glu Leu 
        195                 200                 205             


Gly Val Gly Ser Ser Gly His Leu Ser Glu Gln Glu Leu Ala Val Val 
    210                 215                 220                 


Cys Gln Ser Val Gly Leu Gln Gly Leu Glu Lys Glu Glu Leu Glu Asp 
225                 230                 235                 240 


Leu Phe Asn Lys Leu Asp Gln Asp Gly Asp Gly Lys Val Ser Leu Glu 
                245                 250                 255     


Glu Phe Gln Leu Gly Leu Phe Ser His Glu Pro Ala Leu Leu Leu Glu 
            260                 265                 270         


Ser Ser Thr Arg Val Lys Pro Ser Lys Ala Trp Ser His Tyr Gln Val 
        275                 280                 285             


Pro Glu Glu Ser Gly Cys His Thr Thr Thr Thr Ser Ser Leu Val Ser 
    290                 295                 300                 


Leu Cys Ser Ser Leu Arg Leu Phe Ser Ser Ile Asp Asp Gly Ser Gly 
305                 310                 315                 320 


Phe Ala Phe Pro Asp Gln Val Leu Ala Met Trp Thr Gln Glu Gly Ile 
                325                 330                 335     


Gln Asn Gly Arg Glu Ile Leu Gln Ser Leu Asp Phe Ser Val Asp Glu 
            340                 345                 350         


Lys Val Asn Leu Leu Glu Leu Thr Trp Ala Leu Asp Asn Glu Leu Met 
        355                 360                 365             


Thr Val Asp Ser Ala Val Gln Gln Ala Ala Leu Ala Cys Tyr His Gln 
    370                 375                 380                 


Glu Leu Ser Tyr Gln Gln Gly Gln Val Glu Gln Leu Ala Arg Glu Arg 
385                 390                 395                 400 


Asp Lys Ala Arg Gln Asp Leu Glu Arg Ala Glu Lys Arg Asn Leu Glu 
                405                 410                 415     


Phe Val Lys Glu Met Asp Asp Cys His Ser Thr Leu Glu Gln Leu Thr 
            420                 425                 430         


Glu Lys Lys Ile Lys His Leu Glu Gln Gly Tyr Arg Glu Arg Leu Ser 
        435                 440                 445             


Leu Leu Arg Ser Glu Val Glu Ala Glu Arg Glu Leu Phe Trp Glu Gln 
    450                 455                 460                 


Ala His Arg Gln Arg Ala Ala Leu Glu Trp Asp Val Gly Arg Leu Gln 
465                 470                 475                 480 


Ala Glu Glu Ala Gly Leu Arg Glu Lys Leu Thr Leu Ala Leu Lys Glu 
                485                 490                 495     


Asn Ser Arg Leu Gln Lys Glu Ile Val Glu Val Val Glu Lys Leu Ser 
            500                 505                 510         


Asp Ser Glu Arg Leu Ala Leu Lys Leu Gln Lys Asp Leu Glu Phe Val 
        515                 520                 525             


Leu Lys Asp Lys Leu Glu Pro Gln Ser Ala Glu Leu Leu Ala Gln Glu 
    530                 535                 540                 


Glu Arg Phe Ala Ala Val Leu Lys Glu Tyr Glu Leu Lys Cys Arg Asp 
545                 550                 555                 560 


Leu Gln Asp Arg Asn Asp Glu Leu Gln Ala Glu Leu Glu Gly Leu Trp 
                565                 570                 575     


Ala Arg Leu Pro Lys Asn Arg His Ser Pro Ser Trp Ser Pro Asp Gly 
            580                 585                 590         


Arg Arg Arg Gln Leu Pro Gly Leu Gly Pro Ala Gly Ile Ser Phe Leu 
        595                 600                 605             


Gly Asn Ser Ala Pro Val Ser Ile Glu Thr Glu Leu Met Met Glu Gln 
    610                 615                 620                 


Val Lys Glu His Tyr Gln Asp Leu Arg Thr Gln Leu Glu Thr Lys Val 
625                 630                 635                 640 


Asn Tyr Tyr Glu Arg Glu Ile Ala Ala Leu Lys Arg Asn Phe Glu Lys 
                645                 650                 655     


Glu Arg Lys Asp Met Glu Gln Ala Arg Arg Arg Glu Val Ser Val Leu 
            660                 665                 670         


Glu Gly Gln Lys Ala Asp Leu Glu Glu Leu His Glu Lys Ser Gln Glu 
        675                 680                 685             


Val Ile Trp Gly Leu Gln Glu Gln Leu Gln Asp Thr Ala Arg Gly Pro 
    690                 695                 700                 


Glu Pro Glu Gln Met Gly Leu Ala Pro Cys Cys Thr Gln Ala Leu Cys 
705                 710                 715                 720 


Gly Leu Ala Leu Arg His His Ser His Leu Gln Gln Ile Arg Arg Glu 
                725                 730                 735     


Ala Glu Ala Glu Leu Ser Gly Glu Leu Ser Gly Leu Gly Ala Leu Pro 
            740                 745                 750         


Ala Arg Arg Asp Leu Thr Leu Glu Leu Glu Glu Pro Pro Gln Gly Pro 
        755                 760                 765             


Leu Pro Arg Gly Ser Gln Arg Ser Glu Gln Leu Glu Leu Glu Arg Ala 
    770                 775                 780                 


Leu Lys Leu Gln Pro Cys Ala Ser Glu Lys Arg Ala Gln Met Cys Val 
785                 790                 795                 800 


Ser Leu Ala Leu Glu Glu Glu Glu Leu Glu Leu Ala Arg Gly Lys Arg 
                805                 810                 815     


Val Asp Gly Pro Ser Leu Glu Ala Glu Met Gln Ala Leu Pro Lys Asp 
            820                 825                 830         


Gly Leu Val Ala Gly Ser Gly Gln Glu Gly Thr Arg Gly Leu Leu Pro 
        835                 840                 845             


Leu Arg Pro Gly Cys Gly Glu Arg Pro Leu Ala Trp Leu Ala Pro Gly 
    850                 855                 860                 


Asp Gly Arg Glu Ser Glu Glu Ala Ala Gly Ala Gly Pro Arg Arg Arg 
865                 870                 875                 880 


Gln Ala Gln Asp Thr Glu Ala Thr Gln Ser Pro Ala Pro Ala Pro Ala 
                885                 890                 895     


Pro Ala Ser His Gly Pro Ser Glu Arg Trp Ser Arg Met Gln Pro Cys 
            900                 905                 910         


Gly Val Asp Gly Asp Ile Val Pro Lys Glu Pro Glu Pro Phe Gly Ala 
        915                 920                 925             


Ser Ala Ala Gly Leu Glu Gln Pro Gly Ala Arg Glu Leu Pro Leu Leu 
    930                 935                 940                 


Gly Thr Glu Arg Asp Ala Ser Gln Thr Gln Pro Arg Met Trp Glu Pro 
945                 950                 955                 960 


Pro Leu Arg Pro Ala Ala Ser Cys Arg Gly Gln Ala Glu Arg Leu Gln 
                965                 970                 975     


Ala Ile Gln Glu Glu Arg Ala Arg Ser Trp Ser Arg Gly Thr Gln Glu 
            980                 985                 990         


Gln Ala Ser Glu Gln Gln Ala Arg  Ala Glu Gly Ala Leu  Glu Pro Gly 
        995                 1000                 1005             


Cys His  Lys His Ser Val Glu  Val Ala Arg Arg Gly  Ser Leu Pro 
    1010                 1015                 1020             


Ser His  Leu Gln Leu Ala Asp  Pro Gln Gly Ser Trp  Gln Glu Gln 
    1025                 1030                 1035             


Leu Ala  Ala Pro Glu Glu Gly  Glu Thr Lys Ile Ala  Leu Glu Arg 
    1040                 1045                 1050             


Glu Lys  Asp Asp Met Glu Thr  Lys Leu Leu His Leu  Glu Asp Val 
    1055                 1060                 1065             


Val Arg  Ala Leu Glu Lys His  Val Asp Leu Arg Glu  Asn Asp Arg 
    1070                 1075                 1080             


Leu Glu  Phe His Arg Leu Ser  Glu Glu Asn Thr Leu  Leu Lys Asn 
    1085                 1090                 1095             


Asp Leu  Gly Arg Val Arg Gln  Glu Leu Glu Ala Ala  Glu Ser Thr 
    1100                 1105                 1110             


His Asp  Ala Gln Arg Lys Glu  Ile Glu Val Leu Lys  Lys Asp Lys 
    1115                 1120                 1125             


Glu Lys  Ala Cys Ser Glu Met  Glu Val Leu Asn Arg  Gln Asn Gln 
    1130                 1135                 1140             


Asn Tyr  Lys Asp Gln Leu Ser  Gln Leu Asn Val Arg  Val Leu Gln 
    1145                 1150                 1155             


Leu Gly  Gln Glu Ala Ser Thr  His Gln Ala Gln Asn  Glu Glu His 
    1160                 1165                 1170             


Arg Val  Thr Ile Gln Met Leu  Thr Gln Ser Leu Glu  Glu Val Val 
    1175                 1180                 1185             


Arg Ser  Gly Gln Gln Gln Ser  Asp Gln Ile Gln Lys  Leu Arg Val 
    1190                 1195                 1200             


Glu Leu  Glu Cys Leu Asn Gln  Glu His Gln Ser Leu  Gln Leu Pro 
    1205                 1210                 1215             


Trp Ser  Glu Leu Thr Gln Thr  Leu Glu Glu Ser Gln  Asp Gln Val 
    1220                 1225                 1230             


Gln Gly  Ala His Leu Arg Leu  Arg Gln Ala Gln Ala  Gln His Leu 
    1235                 1240                 1245             


Gln Glu  Val Arg Leu Val Pro  Gln Asp Arg Val Ala  Glu Leu His 
    1250                 1255                 1260             


Arg Leu  Leu Ser Leu Gln Gly  Glu Gln Ala Arg Arg  Arg Leu Asp 
    1265                 1270                 1275             


Ala Gln  Arg Glu Glu His Glu  Lys Gln Leu Lys Ala  Thr Glu Glu 
    1280                 1285                 1290             


Arg Val  Glu Glu Ala Glu Met  Ile Leu Lys Asn Met  Glu Met Leu 
    1295                 1300                 1305             


Leu Gln  Glu Lys Val Asp Lys  Leu Lys Glu Gln Phe  Glu Lys Asn 
    1310                 1315                 1320             


Thr Lys  Ser Asp Leu Leu Leu  Lys Glu Leu Tyr Val  Glu Asn Ala 
    1325                 1330                 1335             


His Leu  Val Arg Ala Leu Gln  Ala Thr Glu Glu Lys  Gln Arg Gly 
    1340                 1345                 1350             


Ala Glu  Lys Gln Ser Arg Leu  Leu Glu Glu Lys Val  Arg Ala Leu 
    1355                 1360                 1365             


Asn Lys  Leu Val Ser Arg Ile  Ala Pro Ala Ala Leu  Ser Val 
    1370                 1375                 1380         


<210>  3850
<211>  2352
<212>  DNA
<213>  Homosapiens

<400>  3850
aggctacggt tcgcgccagc ggccggcgct atggggctga gccgcgtgcg ggcggttttc     60

tttgacttgg acaacactct catcgacacg gccggggcga gcaggagagg catgttggag    120

gtgataaaac tcttacaatc aaaataccat tataaagaag aggctgaaat catctgtgat    180

aaagttcaag ttaaactcag caaggaatgt tttcatcctt acaatacatg cattactgat    240

ttaaggactt cacattggga agaagcaatc caggaaacaa aaggtggtgc agccaataga    300

aaattggctg aagaatgtta tttcctttgg aaatctacac gtttacagca tatgacacta    360

gcagaagacg tcaaagccat gcttactgaa cttcgaaagg aggtccgcct acttctatta    420

acgaatgggg acagacagac ccagagggag aagattgagg cttgtgcctg tcagtcctat    480

tttgacgctg ttgttgtagg tggagagcag agagaggaga aaccagcacc gtccatattt    540

tattactgct gcaatcttct cggagtacaa cctggggact gtgtgatggt cggtgacaca    600

ttagaaaccg acatccaagg aggcctcaat gcaggattga aagcaacagt ctggatcaat    660

aaaaatggaa tagtgccact gaagtcctcc ccagttccgc attacatggt ttcttctgtg    720

ctagagttac ctgctctctt acaaagtata gactgcaaag tcagtatgtc cacttaaagc    780

acataaaagg gcatgattat gaatgttaga atcaatttgc tgagtatgaa ataagaaaag    840

ttagggcact ccacttatga taatccagct ctaagaataa ttttacttat gatttaatgg    900

ccaatatttt gaaggtcttc ccaaccctat tgcttctaag ttgtaacaac caaccattga    960

gtggtactta tatctgaaaa ttcagattgc atgaattcag gtcagtagta tagcccagaa   1020

aatttaagga aatatattat ttgttagtct gtatctggag ctttttaaaa ttatgttatt   1080

aatcttttag tatcttggct gcataatgcc aagcaggatt gctttacaca tggatgcaca   1140

aatgtaaggt ttatcttctg gcttaaaaat agatattttt aaaaaataga ttttctaaaa   1200

cacagattta tgaaagcaag tgaatctggt taatatgaaa taagtactaa gtcacatgca   1260

aatcaaggta ttatatagtg aaattatttt gcatattttg aaaacataaa ccatagtttt   1320

tgcctacttt ggatgtatac tttcttttat gaacctgatt tttctgtatg acattttttt   1380

ttttttcaga gggcagggag caatttttct atggcatgtg acagattcct ccagttagaa   1440

aaagctgtta aaatcaacac atggtgctct tttaccgtga cattttctca cctgtgcaca   1500

gtgagccgat agcttccttt tagtcttcac ctctcaagga aatgttttta ctgtcttttc   1560

ccagacacac agtggggttg agggagctag gctgttttgc tagagataat tgcaaggcac   1620

gtggcactaa aagtcatttt tcttctgtgg atccataaga ggaacatttc ctcagtgtag   1680

cctaacaatg cagcccccaa tctgttcctt tttttttttg aaatgggatc tctgtcgccc   1740

aggttggagt gccatggcac catctcggct cactgcaacc tctgcctcct gagctcaagt   1800

gatcctccca cctcagcctc ccaagggtgt gtgtgactac aagtacacac taccacgccc   1860

agctaatgtg tttttttgta gagatgggat tttgccatgt tgcccaggct ggtctcgaat   1920

tcctggattc aagtgatcct cccacctcag cctcctaaag tcctaggatt ataggcatga   1980

gccactgtgc ctggccctct catctgatag aaaattagat tttgctatga gccatttcct   2040

gagggccaat ttaatactcg tgtgactctt cttagagtta ccatctgcct taaatttcct   2100

ctgtttttca cattcttgga aatatatcat tgttttgcaa atttctatat ctaattcagg   2160

gtttaccagg agcttaataa ttaatggcta catagcaagg catcgtcttg gaaccggaga   2220

attttctcta gactattagg ctagacagtc tcatgattat actaaccaaa cctggagtaa   2280

agtggttgaa aaaaaagaaa gtataaaggg gcttattaaa gtggttaata aatatgaaaa   2340

aaaaaaaaaa aa                                                       2352


<210>  3851
<211>  248
<212>  PRT
<213>  Homosapiens

<400>  3851

Met Gly Leu Ser Arg Val Arg Ala Val Phe Phe Asp Leu Asp Asn Thr 
1               5                   10                  15      


Leu Ile Asp Thr Ala Gly Ala Ser Arg Arg Gly Met Leu Glu Val Ile 
            20                  25                  30          


Lys Leu Leu Gln Ser Lys Tyr His Tyr Lys Glu Glu Ala Glu Ile Ile 
        35                  40                  45              


Cys Asp Lys Val Gln Val Lys Leu Ser Lys Glu Cys Phe His Pro Tyr 
    50                  55                  60                  


Asn Thr Cys Ile Thr Asp Leu Arg Thr Ser His Trp Glu Glu Ala Ile 
65                  70                  75                  80  


Gln Glu Thr Lys Gly Gly Ala Ala Asn Arg Lys Leu Ala Glu Glu Cys 
                85                  90                  95      


Tyr Phe Leu Trp Lys Ser Thr Arg Leu Gln His Met Thr Leu Ala Glu 
            100                 105                 110         


Asp Val Lys Ala Met Leu Thr Glu Leu Arg Lys Glu Val Arg Leu Leu 
        115                 120                 125             


Leu Leu Thr Asn Gly Asp Arg Gln Thr Gln Arg Glu Lys Ile Glu Ala 
    130                 135                 140                 


Cys Ala Cys Gln Ser Tyr Phe Asp Ala Val Val Val Gly Gly Glu Gln 
145                 150                 155                 160 


Arg Glu Glu Lys Pro Ala Pro Ser Ile Phe Tyr Tyr Cys Cys Asn Leu 
                165                 170                 175     


Leu Gly Val Gln Pro Gly Asp Cys Val Met Val Gly Asp Thr Leu Glu 
            180                 185                 190         


Thr Asp Ile Gln Gly Gly Leu Asn Ala Gly Leu Lys Ala Thr Val Trp 
        195                 200                 205             


Ile Asn Lys Asn Gly Ile Val Pro Leu Lys Ser Ser Pro Val Pro His 
    210                 215                 220                 


Tyr Met Val Ser Ser Val Leu Glu Leu Pro Ala Leu Leu Gln Ser Ile 
225                 230                 235                 240 


Asp Cys Lys Val Ser Met Ser Thr 
                245             


<210>  3852
<211>  3264
<212>  DNA
<213>  Homosapiens

<400>  3852
gggcgtcagc gagccgtgag atgcgtggtc caccatcggt gacctcaccg cctcggttcg     60

ccctcagccg ccccgattgg ccatctgcaa gcttcccttc tccgtggaga gcaggaagac    120

agtcatggga cctcagggag ccaggagaca ggctttcttg gcatttgggg atgtcactgt    180

ggatttcacc cagaaggaat ggaggctgct gagccctgct cagagggccc tgtacaggga    240

ggtgacactg gagaactaca gccacctggt ctcactagga attctccatt ctaaaccaga    300

actcatcagg cggctagagc aaggggaagt gccctgggga gaagagagaa gacgccggcc    360

aggcccctgt gcaggaatat atgcagaaca tgtcctgcgg cccaagaatc ttggacttgc    420

acatcagagg caacagcaac tacaattttc tgatcaaagc ttccagagtg acacagctga    480

aggtcaagag aaagaaaaaa gcactaagcc catggcattt tccagcccac ccctaagaca    540

tgcagtaagc tcaaggagga ggaacagtgt agtggaaata gagtctagtc aaggccagag    600

ggaaaatcct acagaaatag acaaagtatt gaaaggaata gaaaattcaa gatggggagc    660

attcaagtgt gcagagcgtg ggcaagactt cagccggaag atgatggtaa tcatacacaa    720

aaaagcacat tccaggcaga aactttttac atgcagggag tgtcaccagg gctttagaga    780

tgagtcagca ttgctcttgc accagaacac acacacagga gagaagtcct atgtgtgcag    840

tgtgtgtggg cgaggcttca gcctcaaggc caacctcctc agacaccaga ggacacactc    900

aggagagaag ccttttctgt gcaaggtgtg tggacgaggc tataccagta agtcatacct    960

cactgtgcat gagagaacac acacaggaga gaagccttat gaatgccagg agtgtgggcg   1020

aaggtttaac gataagtcct catacaacaa gcacttgaag gcgcattcag gggagaagcc   1080

ttttgtgtgc aaggagtgtg ggcgaggcta tactaataag tcatacttcg ttgtgcacaa   1140

gagaatacac tcaggagaga agccttacag atgccaggag tgtggccgag gctttagcaa   1200

taagtcacac cttatcacac accagaggac acactcaggg gagaagccct ttgcgtgcag   1260

gcagtgtaag caaagtttta gcgtgaaagg aagtctcctc agacaccaga gaacacactc   1320

aggggagaag ccttttgtgt gcaaggattg tgagcgaagc tttagccaaa agtcaactct   1380

tgtctaccac cagagaacac actcagggga gaaacctttt gtttgtagag aatgtgggca   1440

aggatttatt cagaagtcaa cccttgtgaa acatcagatc acacactcag aggagaagcc   1500

ttttgtgtgc aaggactgtg gacgaggctt tatccaaaag tcaaccttca ctttacacca   1560

gaggacacac tcagaggaga agccttatgg atgtcgggag tgtgggcgaa ggtttcggga   1620

taagtcctcc tataacaagc acctgagggc acacttgggt gagaaacgtt ttttctgcag   1680

ggattgtggg cgaggcttta ccttgaagcc aaatctcacc atacatcaga ggacacactc   1740

aggagagaag cccttcatgt gcaagcagtg tgagaaaagt tttagtttga aggcaaatct   1800

tcttagacat cagtggacac actcggggga aaggccattt aattgcaagg attgcgggcg   1860

aggcttcatc ctaaaatcaa ctctcctctt ccaccagaag acacactcag gggagaagcc   1920

tttcatctgt agtgaatgtg ggcaaggatt tatctggaag tcaaatcttg tgaaacacca   1980

gcttgcacat tctggcaagc agccttttgt atgcaaggag tgtgggcgag gcttcaactg   2040

gaagggaaat ctcctcacac accagaggac acactcaggg gagaagccct tcgtgtgtaa   2100

tgtgtgtggg caaggcttca gctggaagag aagtctcacc agacaccact ggcggataca   2160

ctcaaaggag aagccttttg tttgccagga gtgtaagcga ggctatacca gtaagtcaga   2220

cctcactgtg catgaaagaa tacacacagg agagaggcct tatgaatgcc aagagtgtgg   2280

acgaaagttt agcaataagt catactacag taagcactta aagagacact tacgtgagaa   2340

gcgtttttgt acagggagtg tgggtgaggc ttcatcttga agttatatct caccatccat   2400

cagaggacac actcaggaga gtaactttgc tttgttacaa gctttagttg aggctgcata   2460

acttgttcgt gaagatataa cagaggcaga cagaatccag agggctacag agaacctgaa   2520

ttcaacccat gtgtccccaa gagattcaga gaaaagaggt caatgtttag ggaacagaga   2580

tgccagttga ggggagggca ttacctgggc tattggggaa atgtggtctc tttcctactg   2640

agcacatatt cttgttgtat ttgtgccagg ctgtgctttc taaggactgc tcttagccag   2700

tgactgcaga gcagggatac caaggcaggc ctgttacact ctccccaacc tccttggact   2760

gcaaacaatc taggacacct ccaccaaacc tcctcttgca ctttccctct ggcttccctc   2820

ccagccttcc ttggtttgga tgttttgtcc cctccttaat ttatgttgaa actctacata   2880

aactgtttac tgttgaaaca gtgtaagtat taggaggtgg gacctttggg aagtgattaa   2940

gtcaagtcac gaagatagag ctttgcgaat gggatcaggt gcccttatga aaaggcttga   3000

tagagggagt ttgtcctgtg gcccttctat tttctgctct gtgaggacac aatgctcctc   3060

ccttccaaaa gatgcagcat gaaggcatca tcttggaaac agacatgagc cctcaacaga   3120

caactgcacc tactgatgtt ttgatgttga acttcccagc ctccagaact ctgggaaaat   3180

aaagtcctct ttatacaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3240

aaaaaaaaaa aaaaaaaaaa aaaa                                          3264


<210>  3853
<211>  751
<212>  PRT
<213>  Homosapiens

<400>  3853

Met Gly Pro Gln Gly Ala Arg Arg Gln Ala Phe Leu Ala Phe Gly Asp 
1               5                   10                  15      


Val Thr Val Asp Phe Thr Gln Lys Glu Trp Arg Leu Leu Ser Pro Ala 
            20                  25                  30          


Gln Arg Ala Leu Tyr Arg Glu Val Thr Leu Glu Asn Tyr Ser His Leu 
        35                  40                  45              


Val Ser Leu Gly Ile Leu His Ser Lys Pro Glu Leu Ile Arg Arg Leu 
    50                  55                  60                  


Glu Gln Gly Glu Val Pro Trp Gly Glu Glu Arg Arg Arg Arg Pro Gly 
65                  70                  75                  80  


Pro Cys Ala Gly Ile Tyr Ala Glu His Val Leu Arg Pro Lys Asn Leu 
                85                  90                  95      


Gly Leu Ala His Gln Arg Gln Gln Gln Leu Gln Phe Ser Asp Gln Ser 
            100                 105                 110         


Phe Gln Ser Asp Thr Ala Glu Gly Gln Glu Lys Glu Lys Ser Thr Lys 
        115                 120                 125             


Pro Met Ala Phe Ser Ser Pro Pro Leu Arg His Ala Val Ser Ser Arg 
    130                 135                 140                 


Arg Arg Asn Ser Val Val Glu Ile Glu Ser Ser Gln Gly Gln Arg Glu 
145                 150                 155                 160 


Asn Pro Thr Glu Ile Asp Lys Val Leu Lys Gly Ile Glu Asn Ser Arg 
                165                 170                 175     


Trp Gly Ala Phe Lys Cys Ala Glu Arg Gly Gln Asp Phe Ser Arg Lys 
            180                 185                 190         


Met Met Val Ile Ile His Lys Lys Ala His Ser Arg Gln Lys Leu Phe 
        195                 200                 205             


Thr Cys Arg Glu Cys His Gln Gly Phe Arg Asp Glu Ser Ala Leu Leu 
    210                 215                 220                 


Leu His Gln Asn Thr His Thr Gly Glu Lys Ser Tyr Val Cys Ser Val 
225                 230                 235                 240 


Cys Gly Arg Gly Phe Ser Leu Lys Ala Asn Leu Leu Arg His Gln Arg 
                245                 250                 255     


Thr His Ser Gly Glu Lys Pro Phe Leu Cys Lys Val Cys Gly Arg Gly 
            260                 265                 270         


Tyr Thr Ser Lys Ser Tyr Leu Thr Val His Glu Arg Thr His Thr Gly 
        275                 280                 285             


Glu Lys Pro Tyr Glu Cys Gln Glu Cys Gly Arg Arg Phe Asn Asp Lys 
    290                 295                 300                 


Ser Ser Tyr Asn Lys His Leu Lys Ala His Ser Gly Glu Lys Pro Phe 
305                 310                 315                 320 


Val Cys Lys Glu Cys Gly Arg Gly Tyr Thr Asn Lys Ser Tyr Phe Val 
                325                 330                 335     


Val His Lys Arg Ile His Ser Gly Glu Lys Pro Tyr Arg Cys Gln Glu 
            340                 345                 350         


Cys Gly Arg Gly Phe Ser Asn Lys Ser His Leu Ile Thr His Gln Arg 
        355                 360                 365             


Thr His Ser Gly Glu Lys Pro Phe Ala Cys Arg Gln Cys Lys Gln Ser 
    370                 375                 380                 


Phe Ser Val Lys Gly Ser Leu Leu Arg His Gln Arg Thr His Ser Gly 
385                 390                 395                 400 


Glu Lys Pro Phe Val Cys Lys Asp Cys Glu Arg Ser Phe Ser Gln Lys 
                405                 410                 415     


Ser Thr Leu Val Tyr His Gln Arg Thr His Ser Gly Glu Lys Pro Phe 
            420                 425                 430         


Val Cys Arg Glu Cys Gly Gln Gly Phe Ile Gln Lys Ser Thr Leu Val 
        435                 440                 445             


Lys His Gln Ile Thr His Ser Glu Glu Lys Pro Phe Val Cys Lys Asp 
    450                 455                 460                 


Cys Gly Arg Gly Phe Ile Gln Lys Ser Thr Phe Thr Leu His Gln Arg 
465                 470                 475                 480 


Thr His Ser Glu Glu Lys Pro Tyr Gly Cys Arg Glu Cys Gly Arg Arg 
                485                 490                 495     


Phe Arg Asp Lys Ser Ser Tyr Asn Lys His Leu Arg Ala His Leu Gly 
            500                 505                 510         


Glu Lys Arg Phe Phe Cys Arg Asp Cys Gly Arg Gly Phe Thr Leu Lys 
        515                 520                 525             


Pro Asn Leu Thr Ile His Gln Arg Thr His Ser Gly Glu Lys Pro Phe 
    530                 535                 540                 


Met Cys Lys Gln Cys Glu Lys Ser Phe Ser Leu Lys Ala Asn Leu Leu 
545                 550                 555                 560 


Arg His Gln Trp Thr His Ser Gly Glu Arg Pro Phe Asn Cys Lys Asp 
                565                 570                 575     


Cys Gly Arg Gly Phe Ile Leu Lys Ser Thr Leu Leu Phe His Gln Lys 
            580                 585                 590         


Thr His Ser Gly Glu Lys Pro Phe Ile Cys Ser Glu Cys Gly Gln Gly 
        595                 600                 605             


Phe Ile Trp Lys Ser Asn Leu Val Lys His Gln Leu Ala His Ser Gly 
    610                 615                 620                 


Lys Gln Pro Phe Val Cys Lys Glu Cys Gly Arg Gly Phe Asn Trp Lys 
625                 630                 635                 640 


Gly Asn Leu Leu Thr His Gln Arg Thr His Ser Gly Glu Lys Pro Phe 
                645                 650                 655     


Val Cys Asn Val Cys Gly Gln Gly Phe Ser Trp Lys Arg Ser Leu Thr 
            660                 665                 670         


Arg His His Trp Arg Ile His Ser Lys Glu Lys Pro Phe Val Cys Gln 
        675                 680                 685             


Glu Cys Lys Arg Gly Tyr Thr Ser Lys Ser Asp Leu Thr Val His Glu 
    690                 695                 700                 


Arg Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Gln Glu Cys Gly Arg 
705                 710                 715                 720 


Lys Phe Ser Asn Lys Ser Tyr Tyr Ser Lys His Leu Lys Arg His Leu 
                725                 730                 735     


Arg Glu Lys Arg Phe Cys Thr Gly Ser Val Gly Glu Ala Ser Ser 
            740                 745                 750     


<210>  3854
<211>  2786
<212>  DNA
<213>  Homosapiens

<400>  3854
tgaaatagga gccaaggtat gctatgagcc aaggattatg agtaatccaa ttttgtgcac     60

tttaagccat ttgaaaaaca gaaaagcaaa acaacaaaat aatttttaag aaattgaata    120

tagggtgtta tgctctgaat gtgtccccct aaaattaatc accaatgtca taagattagg    180

aagtagggct ttaaggtagt gattcagtca tgaagggaga gtgttcacga atgagtttag    240

gatccttaca caaggactgg atggagtggg cttcccctgt tttgcccttc caccttctgc    300

catgtgagga cacagtgcat ctcctcctga agacacagtg cacaagatac catcttggat    360

gcagagacca gaccctcacc agacaccaat cctgctggca ccttgatctt ggacttctag    420

cctatggaac tgtaagattg gggaagatgc caggtgatag aatccaccct gcctctgaca    480

gcatccaatc tggagcaaag gcttatttca accctccccc aagctcccaa tacaagccca    540

aattctggaa caggtccttt ccaacacctc cttcagagaa gctccctggc tccaggcagt    600

gcttgctccc ctcactgcag caggaagcct aacttgcgaa ctgcaggtgt gttccaggtg    660

gtcactggat gcaaggcatt gacagatgga tcccatcgat acccccactg caaaaccata    720

gtgcagtgaa tagaagacac ttctctgcac cccaaaagct ccatgctgat tgtgagaagg    780

aaatgctgga tggaggggtt cctggaacta ctgtgagggt ttcttttgat ttctcctgct    840

tagaaatggt gagagaactt tggatgtgga acgtggagga ggaggaacac gaagtgggga    900

tctccacttg gggtggtcag cactgcgggt gcccagcaaa gtcactgcct ggtccacatc    960

ccggaggggt ctctgcgcct cagtcggcat cgcagctgat ggtgaaactt ttggtgtggc   1020

agaagagtgt ccacaaactt cggaagatcg ctgctcagag tgaggaatgg agttgtattt   1080

tgaataaaat atccacgcat ccttttgtga gcaaggagca tgatggtact tagacctacc   1140

atttctcgtt atggtggttg cggttacagt ggggctgggg tgtttacctg gagcctggac   1200

atccactggg acatgatacc cactgggaat tttttgtgtc aatctggtct ctgatgtcca   1260

cctggggatt gggtatccac ctaaggcctg atgtttacct ggagccagat gtgcacctga   1320

gacctgatgt ctatctgtgg ccttatgttc ccctggggac cgatgcacac ctgaaggata   1380

ggtattcatc tggggcctga tacccaccag tagtatgggt gtcaaccttg gggctggtgt   1440

tcagctggcg tccactgtct acttggggcc tggtgtacac atggggcctg ggcatccacc   1500

tgagacttga tgtttaatat ggtctggagt tcttttgggg cctgttgtac cctggagcct   1560

gggtgtacac ctggagcctg atgtcccagg tgaacaactg ggtcccaggt gatcttcagg   1620

ccctaggtga aaactccagg ctctaggtgg acaaccaggc tccaggctga tgtttactgg   1680

ggccagatgt ctaccaggcc ccaggtgaaa tccccaggct ccaaatggac aacatagccc   1740

caggttccag gtggacattg gaatccagat caacaccagg ccccagatgg acacccaggc   1800

ctgtggtgga catcggactg cagaaggtca tctggctcga ggtggacatc gggccccagg   1860

tggatgcctg gtccccaggt ggatatcggg ccccacttgg acaccagtcc ctgggtggat   1920

accttggcct cgggtggata tccagtctct agctaagcat caggctccag ggggacccag   1980

gccctagctg actggggact agtgttcata tggggccaca tgtccatctg ggccctaggt   2040

gtcaacttgt agcctgatgt caacctggaa gctggtgttc accagagagg actaaggtcc   2100

tcctggtgcc tggtgtccaa cttgggactt tgtgtccacc tggagaccga tgtccacttg   2160

ggaccggatg tccagctgga gcaagatgtc cacctgcagc ctaaaacttc acctaaggcc   2220

tgatgttccc cagggcctac agagcctatg tatctaccta gggacttgtg tccaggtggg   2280

gcctgaattc cacctggggc ctggaattaa cctgggacct gatgtccacc tgagacgtgg   2340

gtgttcctct ggagtctgat atctatctgg ggcccgggtg tcctcctgtg gtctgatgtc   2400

cacttgtagg ctggtgtcca cctggggcct gggtgtccac ctaggaacct gatgtatacc   2460

tgaagtccag tgtctacgtg ggtactgatg tctaccagga aagtgatata aacctggggc   2520

ctgatagcca cctgggccct gagtgtccac atatgttctg atttctcttt tggcctgagt   2580

gtagggcctg agtgccacct gcttcctgac gttcaccagg aacctaggta ttcacttggg   2640

agccctgggg gcctctgccc ttttggccgc gttgtctcct ggcttttagg gtggtgggat   2700

tctcggctct gattgcagca ggtggattca cttagctctc ctcccctttt agcattactg   2760

tcttctgtaa taaacctctc actttg                                        2786


<210>  3855
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  3855

Met Gln Gly Ile Asp Arg Trp Ile Pro Ser Ile Pro Pro Leu Gln Asn 
1               5                   10                  15      


His Ser Ala Val Asn Arg Arg His Phe Ser Ala Pro Gln Lys Leu His 
            20                  25                  30          


Ala Asp Cys Glu Lys Glu Met Leu Asp Gly Gly Val Pro Gly Thr Thr 
        35                  40                  45              


Val Arg Val Ser Phe Asp Phe Ser Cys Leu Glu Met Val Arg Glu Leu 
    50                  55                  60                  


Trp Met Trp Asn Val Glu Glu Glu Glu His Glu Val Gly Ile Ser Thr 
65                  70                  75                  80  


Trp Gly Gly Gln His Cys Gly Cys Pro Ala Lys Ser Leu Pro Gly Pro 
                85                  90                  95      


His Pro Gly Gly Val Ser Ala Pro Gln Ser Ala Ser Gln Leu Met Val 
            100                 105                 110         


Lys Leu Leu Val Trp Gln Lys Ser Val His Lys Leu Arg Lys Ile Ala 
        115                 120                 125             


Ala Gln Ser Glu Glu Trp Ser Cys Ile Leu Asn Lys Ile Ser Thr His 
    130                 135                 140                 


Pro Phe Val Ser Lys Glu His Asp Gly Thr 
145                 150                 


<210>  3856
<211>  476
<212>  DNA
<213>  Homosapiens

<400>  3856
gtttagatgt tttcctagaa acatgattgt ttattggcat tgatctcaca gtctggtgag     60

gacttcttta ctgataatgt caagttcagg ttaccctccc aaccaaggag cattcagcac    120

agaacaaagt cattatcctc ctcactctgt aaagtatacg tttcccagca cccaccacca    180

gcaggatcca gcatttggag gcaaacatga agctccatcc tctccaattc tggggcaacc    240

gtgtggagat gatcaaaatg cttcaccttc aaaactttca aaggaagagt taatagagtg    300

tatggatcgt gtagatcgag aaattgcaaa agtagaacag cagatcctta aactgaaaaa    360

gaaacaagta aaagtcttcg tctaatatat tctaagaatg tatgtttttc tccctacaga    420

agatattttt gagttttcca tattttgaaa ctttacataa aaggaatcat tcctta        476


<210>  3857
<211>  102
<212>  PRT
<213>  Homosapiens

<400>  3857

Met Ser Ser Ser Gly Tyr Pro Pro Asn Gln Gly Ala Phe Ser Thr Glu 
1               5                   10                  15      


Gln Ser His Tyr Pro Pro His Ser Val Lys Tyr Thr Phe Pro Ser Thr 
            20                  25                  30          


His His Gln Gln Asp Pro Ala Phe Gly Gly Lys His Glu Ala Pro Ser 
        35                  40                  45              


Ser Pro Ile Leu Gly Gln Pro Cys Gly Asp Asp Gln Asn Ala Ser Pro 
    50                  55                  60                  


Ser Lys Leu Ser Lys Glu Glu Leu Ile Glu Cys Met Asp Arg Val Asp 
65                  70                  75                  80  


Arg Glu Ile Ala Lys Val Glu Gln Gln Ile Leu Lys Leu Lys Lys Lys 
                85                  90                  95      


Gln Val Lys Val Phe Val 
            100         


<210>  3858
<211>  1911
<212>  DNA
<213>  Homosapiens

<400>  3858
atggtagcgc tgcataaggg gaggatcccg ccggcagggc ccagcgtcct agcgggttgg     60

gacgcggctg acagcgagcg atggctgcgc gcagcgttcc gtccggcgag tgacccccct    120

ccgccgcgag tcagctctcc gcccgctccc ttgccgagtc gcgaccggtg cggacgacgg    180

cgtttgcgtg gcacgtggtc gggccgcctg gccctgggaa agcgtcccac ggtgggggcg    240

cgccggtctc ccggagcggg accgggtcgg aggatggacg agaatcacga gcgatgtggc    300

cctggcgttg agtttgtggc tgtggtcgct tcggggcccc ggtggcggga ccaggggctc    360

gtgaggcagg tcttggtggg tgccgagggc cttccggcgt cccaggcggg gcgccgcggg    420

accgccctcg tgtctgtggc ggtgggatcc cgcggccgtg ttttcctggt ggcccggcca    480

tgcctgaggt ttctccctca gccgcccctc tgcgggctcc caggtgccct tgccctcgcg    540

gtccccggcc cttgcctgtc tgcgccccct tccccgcccg ccgcccgccg atcctctctc    600

ctccccgagc ggctcaccgg ctttacgtcg gttggtggcc gcgtctggga ccgaaccggg    660

caccgccttg tggaaaaaaa agaatagaat ataccctgtt aaatcagaca tgatacttgc    720

ttttgtggag cttatgcttt agtgcagaaa cagaaagtca agcaaaaact caaactatgt    780

aactttaaat tggatatgtg ctaatgaagg aaaatgtggc actgtaagaa aaaataatag    840

ggagttaaag gataaatagg agtttgctgg atgaaattta tgaagagctg aagatttcaa    900

acaaaagaaa ctgatgcagg agggtgcagc tttggagtca agaatgaagt tctaggagat    960

agagagcaaa gaaatggtgg gagaggaggt caaacaagac aaatctctcc tctgccttct   1020

ccttatcaga ctactcaaca tgaaggcaat aagaatgaag acctctatgt ataataattg   1080

acttccactt aataaataag gttacttggt acactggtcg acaaaacctt gaaatgttga   1140

tgtttaaggg ctgttgattg ctggcagcaa agaagtccaa ctgtgctggt acccgagata   1200

gcgtctccac attttcttcc aggatcatca cctttgttct aaatagctcc cacatagtgt   1260

gaacagaagt catatgtttt agattttctg ccttggcacc caggaaacca gtatgattga   1320

gtaaacatat taaacttcct ctgcatttcc agcctgaaca gatgttgagt acaagctgat   1380

ccacctacgt tcaacctgag agagtccaca tccacagact gtttcatttc cctttttcaa   1440

tttacataga agcatagatt cttgctggca tatacaaatg cgccatttaa ggcaatcaaa   1500

aatggttcca catctcatct gatttccaca attgttgctg taacgatgga ctactgagga   1560

gagagacaat ttctctggca catcttccca cattttagca acatgttcat ggagagccaa   1620

tattcagtaa ttacagccca attcctcaca atttcacaat tcgctaacaa tatgcatttt   1680

cacaatgtaa agctgatttt cctttaacca aatcaaacat gaaaagatag ctgcatgcaa   1740

tgggcaatct agatcattag aagattgatg taaaattaga ggacactgag actggaatag   1800

attgcaaact tcagggagct cagaaaactt gtaaactcta cattttgagg aaatatgttg   1860

tcgatgcttt tgcaactcta tgcagtaact taacaaataa agccttaaag t            1911


<210>  3859
<211>  228
<212>  PRT
<213>  Homosapiens

<400>  3859

Met Val Ala Leu His Lys Gly Arg Ile Pro Pro Ala Gly Pro Ser Val 
1               5                   10                  15      


Leu Ala Gly Trp Asp Ala Ala Asp Ser Glu Arg Trp Leu Arg Ala Ala 
            20                  25                  30          


Phe Arg Pro Ala Ser Asp Pro Pro Pro Pro Arg Val Ser Ser Pro Pro 
        35                  40                  45              


Ala Pro Leu Pro Ser Arg Asp Arg Cys Gly Arg Arg Arg Leu Arg Gly 
    50                  55                  60                  


Thr Trp Ser Gly Arg Leu Ala Leu Gly Lys Arg Pro Thr Val Gly Ala 
65                  70                  75                  80  


Arg Arg Ser Pro Gly Ala Gly Pro Gly Arg Arg Met Asp Glu Asn His 
                85                  90                  95      


Glu Arg Cys Gly Pro Gly Val Glu Phe Val Ala Val Val Ala Ser Gly 
            100                 105                 110         


Pro Arg Trp Arg Asp Gln Gly Leu Val Arg Gln Val Leu Val Gly Ala 
        115                 120                 125             


Glu Gly Leu Pro Ala Ser Gln Ala Gly Arg Arg Gly Thr Ala Leu Val 
    130                 135                 140                 


Ser Val Ala Val Gly Ser Arg Gly Arg Val Phe Leu Val Ala Arg Pro 
145                 150                 155                 160 


Cys Leu Arg Phe Leu Pro Gln Pro Pro Leu Cys Gly Leu Pro Gly Ala 
                165                 170                 175     


Leu Ala Leu Ala Val Pro Gly Pro Cys Leu Ser Ala Pro Pro Ser Pro 
            180                 185                 190         


Pro Ala Ala Arg Arg Ser Ser Leu Leu Pro Glu Arg Leu Thr Gly Phe 
        195                 200                 205             


Thr Ser Val Gly Gly Arg Val Trp Asp Arg Thr Gly His Arg Leu Val 
    210                 215                 220                 


Glu Lys Lys Glu 
225             


<210>  3860
<211>  898
<212>  DNA
<213>  Homosapiens

<400>  3860
ggggattcac cgtttgggtg aagacggagg cgggttctgg acagacgtag gctgtcaggg     60

agtgtttact tcgcctccac ttctgttcct ccctgccctg gtgctgctcc aggtcacata    120

ctcgtcctga gccggcttca gcctgtccgc gcagaagtct cccggagcca tggcctagta    180

ctcttatgtg aagtctagca agctcgtgct caagggaacc gaggtgaaga gctgggtcct    240

gcagctctgg tgggagcctc ctcagttctt ttcggatgca ctccaccccc gcgaatccgg    300

tggaagccgt ggtgcagaga gccggctttg tggcctccca ggcttcgctc cgaccctgga    360

aacaggatag acgggcgggt gacccgtggc cccgtaccca cgagtttggg taccctgagg    420

catctctcca ggcctctgcc tgtaagaaga aaaagagcaa agataagaag agaaaaagag    480

aagatgaaga aacccagctt gatacgttgg aatctggtga acagtaacaa actttggtga    540

aatttcagga accatagcca ttgaaatgga tgagggaacc tatatacatg cactcgacaa    600

tggtcttttt accctgggag ctccacacaa agaagaatcg ccctgaaatc tggctatgga    660

aaatatcttg gtataaattc agatgaactt gttgggcatt cagatgcaat tggaccaaga    720

gaacaatggg aaccagtctt tcaaaatggg aaaatggctt tgttggcctc aaatagctgc    780

tttattagat gcaatgaagc aggggacata gaagcaaaaa gtaaaacagc aggagaagaa    840

gaaatgatca agattagatc ctgtgcggaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa      898


<210>  3861
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  3861

Met His Ser Thr Pro Ala Asn Pro Val Glu Ala Val Val Gln Arg Ala 
1               5                   10                  15      


Gly Phe Val Ala Ser Gln Ala Ser Leu Arg Pro Trp Lys Gln Asp Arg 
            20                  25                  30          


Arg Ala Gly Asp Pro Trp Pro Arg Thr His Glu Phe Gly Tyr Pro Glu 
        35                  40                  45              


Ala Ser Leu Gln Ala Ser Ala Cys Lys Lys Lys Lys Ser Lys Asp Lys 
    50                  55                  60                  


Lys Arg Lys Arg Glu Asp Glu Glu Thr Gln Leu Asp Thr Leu Glu Ser 
65                  70                  75                  80  


Gly Glu Gln 
            


<210>  3862
<211>  2982
<212>  DNA
<213>  Homosapiens

<400>  3862
gcgtacaaaa ccggagcctc gggccgggct gcgtgaggga ggagggttca tcatgcctag     60

tggcgtataa gaagaccccg ccaccggtcc ctccacgcac cacttcaaag ccgttcatct    120

cagtcacagt ccagagcagt actgagtctg cccaggacac ctacctggac agccaggacc    180

acaagagcga ggtgactagc cagtcgggcc tgagcaactc gtcggacagc ctggacagca    240

gtacccgacc gcccagcgtg acacggggtg gagtcgcccc agcccctgag gccccagagc    300

cacccccaaa acatgcagct ctgaaaagtg aacaagggac gctgaccagc tctgagtccc    360

accccgaggc cgcccccaaa aggaaactgt catcgatagg aatacaagtt gactgcattc    420

agccagtgcc aaaagaggag cccagtcccg ctaccaaatt ccagtccatc ggggttcagg    480

tagaggacga ctggcgaagc agcgtcccct ctcacagtat gtcctcccga cgggacacag    540

actcggatac ccaggatgcc aatgactcaa gctgtaagtc atctgagagg agcctcccgg    600

actgtacccc tcaccccaac tccatcagca tcgatgccgg tccccggcag gcccccaaga    660

ttgcccagat caagcgcaac ctctcctatg gagacaacag cgaccctgcc ctagaggcgt    720

cctcgctgcc cccacccgac ccctggctcg agacctcctc cagctcccca gcagagccgg    780

cacagccagg ggcctgccgc cgagacggct actggttcct aaagctactg caggcagaaa    840

cagagcggct ggaaggctgg tgctgccaga tggacaagga gaccaaagag aacaacctct    900

ctgaagaagt cttaggaaaa gtcctcagtg ctgtgggcag tgcccagcta ctgatgtccc    960

agaaattcca gcagttccgg ggcctctgtg agcaaaactt gaaccctgat gccaacccac   1020

gccccacagc ccaggacctg gcagggttct gggacctgct acagctgtcc atcgaggata   1080

tcagcatgaa gttcgatgaa ctctaccacc tcaaggccaa cagctggcag ctggtggaga   1140

cccccgagaa gaggaaggaa gagaagaaac caccccctcc ggtcccaaag aagccagcca   1200

aatccaagcc ggcagtgagc cgcgacaagg cctcagacgc cagcgacaag cagcgccagg   1260

aggcccgcaa gagactcctg gcggccaagc gggcagcttc tgtgcggcag aactcagcca   1320

ccgagagcgc agacagcatc gagatttatg tcccggaggc ccagaccagg ctctgagacc   1380

atgcaggagg aaagaaacga ttttaaatca ttaaaaacac aaaaactaag tgcgaacgga   1440

acagagtttt ctcaaccttt gctatggtta ttctgtctag agaccctgag ccaactttca   1500

aattgacgca tacaagggct cacaatttgg cttttttggg tccctcccag ctttaggtta   1560

tgaagatttt actcacaaaa aaaatcaaca aaaatcacga aactagaaaa cttttttttt   1620

cctcttgctg gccgtggtgg actagataga tggacgtcgg caactcccgg cccagcctcc   1680

atactgcggt ctttttactc gttctatctg atgagaactc acactagctt gtttacaaga   1740

tgacgacagt ccaagggcag ccttgggcac ctgccatgtc cctcctttcc ccagctatcc   1800

ccgctctgac cttgattttc attcttatgt ttttctcttt tcccttcaga gctcacacag   1860

tggtcaccat tgtggcaagc ggctttctgg gtctcagccc tctctgcggt tgagggccca   1920

gaggacagag agatggacat gcgtcccctc cctccccccg ccaagtgctc acacacaacc   1980

tcacgcgcac acacacacac gcagatggag gcgcctcact gggaggtgcc ccgccagccc   2040

tgggcagtgt caggcaggac tcactcaccg ctgagcagat gagggaagtt ttagtcttgg   2100

cgggtggaaa tgagacgaag ccacagttat cacactccag actcctgccc ttttattttc   2160

tccagcccct tcttccttca gcaaaatcta ggactcccga gtggcttcca gggggccgtc   2220

agtcctcagc cgcgcctgtg tccggtgccc gaggggcggg cggcggtgtc tgtatgtatg   2280

tgtacatatg cacatagacc ttagagtgta tagttaacaa acgcccatct gctcacccat   2340

gcccacccag cgccgccgcc gctggctctc ggggcacctg gcaggaggcg ggtgtgtgaa   2400

tagcatatat ttttacatgt actatatcta ggtgtgtgta caagtgtgtg taaaaatata   2460

taccttgtgt gtaagcagcc cttttttttt ttggtctcca cccccctccc cccgccccgc   2520

actcctaagg gcccatctgc ccagcctctg agttttctgt tctatttttt ttttaacccc   2580

aattatcctt ctctctctcc tgcccccgca tcccactccc agggtgtcac gagccctgag   2640

ctgcaatggc ccgggcctgc agggcggggt aggggagggc aggggctgag ccccgaagcc   2700

agctcagtac ctgaggggct gctctatgct gtgtatgcgc ctctctggca tccgagacat   2760

cctcttggct ggcgcttgct gcaggggggg accccccccc gtccccaggt gaaccaaggg   2820

tctgctccgg ggcccatttc cagcttggcc gccgtctgtg accttgggca agtcacttga   2880

cctctgtgtg cctcaacttc ctcctctgta aaacggggac agtccctgcc cctccctacc   2940

tcacaggcat gttgtgagaa taaatgaggt aacgtgtacc aa                      2982


<210>  3863
<211>  285
<212>  PRT
<213>  Homosapiens

<400>  3863

Met Ser Ser Arg Arg Asp Thr Asp Ser Asp Thr Gln Asp Ala Asn Asp 
1               5                   10                  15      


Ser Ser Cys Lys Ser Ser Glu Arg Ser Leu Pro Asp Cys Thr Pro His 
            20                  25                  30          


Pro Asn Ser Ile Ser Ile Asp Ala Gly Pro Arg Gln Ala Pro Lys Ile 
        35                  40                  45              


Ala Gln Ile Lys Arg Asn Leu Ser Tyr Gly Asp Asn Ser Asp Pro Ala 
    50                  55                  60                  


Leu Glu Ala Ser Ser Leu Pro Pro Pro Asp Pro Trp Leu Glu Thr Ser 
65                  70                  75                  80  


Ser Ser Ser Pro Ala Glu Pro Ala Gln Pro Gly Ala Cys Arg Arg Asp 
                85                  90                  95      


Gly Tyr Trp Phe Leu Lys Leu Leu Gln Ala Glu Thr Glu Arg Leu Glu 
            100                 105                 110         


Gly Trp Cys Cys Gln Met Asp Lys Glu Thr Lys Glu Asn Asn Leu Ser 
        115                 120                 125             


Glu Glu Val Leu Gly Lys Val Leu Ser Ala Val Gly Ser Ala Gln Leu 
    130                 135                 140                 


Leu Met Ser Gln Lys Phe Gln Gln Phe Arg Gly Leu Cys Glu Gln Asn 
145                 150                 155                 160 


Leu Asn Pro Asp Ala Asn Pro Arg Pro Thr Ala Gln Asp Leu Ala Gly 
                165                 170                 175     


Phe Trp Asp Leu Leu Gln Leu Ser Ile Glu Asp Ile Ser Met Lys Phe 
            180                 185                 190         


Asp Glu Leu Tyr His Leu Lys Ala Asn Ser Trp Gln Leu Val Glu Thr 
        195                 200                 205             


Pro Glu Lys Arg Lys Glu Glu Lys Lys Pro Pro Pro Pro Val Pro Lys 
    210                 215                 220                 


Lys Pro Ala Lys Ser Lys Pro Ala Val Ser Arg Asp Lys Ala Ser Asp 
225                 230                 235                 240 


Ala Ser Asp Lys Gln Arg Gln Glu Ala Arg Lys Arg Leu Leu Ala Ala 
                245                 250                 255     


Lys Arg Ala Ala Ser Val Arg Gln Asn Ser Ala Thr Glu Ser Ala Asp 
            260                 265                 270         


Ser Ile Glu Ile Tyr Val Pro Glu Ala Gln Thr Arg Leu 
        275                 280                 285 


<210>  3864
<211>  5011
<212>  DNA
<213>  Homosapiens

<400>  3864
ggggcgcccg cgggccggag ccggggcggg ggccggggcc taggcgcgcg gacctgcgag     60

cggacccgag aggcggcggc ggcgcagcgg aacggcagag cgggccggag gcggccgagg    120

cgcccggcgc aggcacccgt gcctcccctc tgccaggaac cttggggcct tgtgtgtgac    180

caggacctgg tggcccccgg gcggtggcag agcccctgtc ccaagctgct tcctgccggc    240

acctctgatc aagtgcctag agggatgtgt gtgccagccc tcggtccagt gcccgctcct    300

gagctgactc ctgctgggcc ccgacagctt gccgtgtttc ctgtgcctgt agctccctgg    360

ttggatagct gccgcccggg agaggtgacc cgggcgccct gctagggtga aggcccctgc    420

cctcggcccg ggatcatgaa aggcctcggt gacagccgcc cccgccacct ctccgacagc    480

ctagacccac cccacgagcc cctgtttgca gggaccgacc gcaaccccta cctgctgtcg    540

cccacggagg ccttcgcccg cgaggcccgc ttccccgggc agaacaccct gccaggagat    600

ggcctctttc ccctcaacaa ccagctgccc ccgcccagca gcacctttcc ccgcatccac    660

tacaactccc acttcgaggt gccagaggag agccccttcc ccagccatgc ccaagccacc    720

aagatcaacc ggctgcccgc caacctcctg gaccagtttg agaagcagct gcccatccac    780

cgtgatggct tcagcaccct ccaatttccc cgtggcgagg ccaaggcccg tggtgagagc    840

cctggccgca tccgccacct ggtccactca gtccagcggc ttttcttcac caaggcaccc    900

tcactggagg gcacagcggg caaggtcggt ggcaatggca gcaagaaggg tggcatggag    960

gacggcaagg gccggagggc caaaagcaag gagcgggcca aggctgggga gcccaaacgg   1020

cgcagccgct ccaacatctc aggctggtgg agctccgatg acaacttgga cggcgaggcc   1080

ggcgccttcc gcagcagtgg cccagcctct gggctgatga cactaggccg ccaggcagaa   1140

cgcagccagc cacgctactt catgcacgcc tacaacacca tcagtgggca catgctcaaa   1200

accaccaaga acaacactac tgagctgact gccccaccac ccccgcccgc acccccagcc   1260

acctgcccca gccttggggt gggcactgac accaactacg tcaaacgggg ctcctggtcc   1320

actctgaccc tcagccacgc ccacgaggtc tgccagaaga cctcagccac cttggataag   1380

agcctgctca agtccaaatc ctgccaccag ggtctagcct accattacct gcaggtgccc   1440

ggcggcggcg gcgagtggag caccacgctg ctgtccccac gcgagacgga tgccgcggcc   1500

gagggcccta tcccgtgccg gcgcatgcgc agcggcagct acatcaaggc catgggcgac   1560

gaggacagcg acgagtccgg cggcagcccc aagccctcac ccaagaccgc ggcgcggcgc   1620

cagagctatc tgagggccac gcagcagtcg ctgggagagc agagcaaccc ccgcaggagt   1680

ctggaccgcc tggattcagt ggacatgctg ctgccctcca agtgtccgag ctgggaagag   1740

gactacaccc ccgtcagcga cagcctcaac gactccagct gcatcagcca gatttttgga   1800

caggcctccc tgatccccca gttgtttggc catgagcagc aggtacggga ggcagagctg   1860

agtgaccagt atgaggcggc ctgcgagtca gcctgcagtg aagcggagtc cacagcggca   1920

gagacgcttg acttgccact gcccagctac ttccgctccc gcagccacag ctacctgcgt   1980

gccatccagg caggctgctc gcaggaggag gacagtgtct ccctgcagtc cctctcccca   2040

ccgcccagta ccggcagcct cagcaatagt cgcacgcttc cgagttcatc atgcctagtg   2100

gcgtataaga agaccccgcc accggtccct ccacgcacca cttcaaagcc gttcatctca   2160

gtcacagtcc agagcagtac tgagtctgcc caggacacct acctggacag ccaggaccac   2220

aagagcgagg tgactagcca gtcgggcctg agcaactcgt cggacagcct ggacagcagt   2280

acccgaccgc ccagcgtgac acggggtgga gtcgccccag cccctgaggc cccagagcca   2340

cccccaaaac atgcagctct gaaaagtgaa caagggacgc tgaccagctc tgagtcccac   2400

cccgaggccg cccccaaaag gaaactgtca tcgataggaa tacaagagag gactagaagg   2460

aacggttccc acctctcgga ggacaacgga cccaaagcga tcgatgtgat ggcaccctcc   2520

tcagaaagca gcgtcccctc tcacagtatg tcctcccgac gggacacaga ctcggatacc   2580

caggatgcca atgactcaag ctgtaagtca tctgagagga gcctcccgga ctgtacccct   2640

caccccaact ccatcagcat cgatgccggt ccccggcagg cccccaagat tgcccagatc   2700

aagcgcaacc tctcctatgg agacaacagc gaccctgccc tagaggcgtc ctcgctgccc   2760

ccacccgacc cctggctcga gacctcctcc agctccccag cagagccggc acagccaggg   2820

gcctgccgcc gagacggcta ctggttccta aagctactgc aggcagaaac agagcggctg   2880

gaaggctggt gctgccagat ggacaaggag accaaagaga acaacctctc tgaagaagtc   2940

ttaggaaaag tcctcagtgc tgtgggcagt gcccagctac tgatgtccca gaaattccag   3000

cagttccggg gcctctgtga gcaaaacttg aaccctgatg ccaacccacg ccccacagcc   3060

caggacctgg cagggttctg ggacctgcta cagctgtcca tcgaggatat cagcatgaag   3120

ttcgatgaac tctaccacct caaggccaac agctggcagc tggtggagac ccccgagaag   3180

aggaaggaag agaagaaacc accccctccg gtcccaaaga agccagccaa atccaagccg   3240

gcagtgagcc gcgacaaggc ctcagacgcc agcgacaagc agcgccagga ggcccgcaag   3300

agactcctgg cggccaagcg ggcagcttct gtgcggcaga actcagccac cgagagcgca   3360

gacagcatcg agatttatgt cccggaggcc cagaccaggc tctgagacca tgcaggagga   3420

aagaaacgat tttaaatcat taaaaacaca aaaactaagt gcgaacggaa cagagttttc   3480

tcaacctttg ctatggttat tctgtctaga gaccctgagc caactttcaa attgacgcat   3540

acaagggctc acaatttggc ttttttgggt ccctcccagc tttaggttat gaagatttta   3600

ctcacaaaaa aaatcaacaa aaatcacgaa actagaaaac tttttttttc ctcttgctgg   3660

ccgtggtgga ctagatagat ggacgtcggc aactcccggc ccagcctcca tactgcggtc   3720

tttttactcg ttctatctga tgagaactca cactagcttg tttacaagat gacgacagtc   3780

caagggcagc cttgggcacc tgccatgtcc ctcctttccc cagctatccc cgctctgacc   3840

ttgattttca ttcttatgtt tttctctttt cccttcagag ctcacacagt ggtcaccatt   3900

gtggcaagcg gctttctggg tctcagccct ctctgcggtt gagggcccag aggacagaga   3960

gatggacatg cgtcccctcc ctccccccgc caagtgctca cacacaacct cacgcgcaca   4020

cacacacacg cagatggagg cgcctcactg ggaggtgccc cgccagccct gggcagtgtc   4080

aggcaggact cactcaccgc tgagcagatg agggaagttt tagtcttggc gggtggaaat   4140

gagacgaagc cacagttatc acactccaga ctcctgccct tttattttct ccagcccctt   4200

cttccttcag caaaatctag gactcccgag tggcttccag ggggccgtca gtcctcagcc   4260

gcgcctgtgt ccggtgcccg aggggcgggc ggcggtgtct gtatgtatgt gtacatatgc   4320

acatagacct tagagtgtat agttaacaaa cgcccatctg ctcacccatg cccacccagc   4380

gccgccgccg ctggctctcg gggcacctgg caggaggcgg gtgtgtgaat agcatatatt   4440

tttacatgta ctatatctag gtgtgtgtac aagtgtgtgt aaaaatatat accttgtgtg   4500

taagcagccc tttttttttt tggtctccac ccccctcccc ccgccccgca ctcctaaggg   4560

cccatctgcc cagcctctga gttttctgtt ctattttttt tttaacccca attatccttc   4620

tctctctcct gcccccgcat cccactccca gggtgtcacg agccctgagc tgcaatggcc   4680

cgggcctgca gggcggggta ggggagggca ggggctgagc cccgaagcca gctcagtacc   4740

tgaggggctg ctctatgctg tgtatgcgcc tctctggcat ccgagacatc ctcttggctg   4800

gcgcttgctg caggggggga cccccccccg tccccaggtg aaccaagggt ctgctccggg   4860

gcccatttcc agcttggccg ccgtctgtga ccttgggcaa gtcacttgac ctctgtgtgc   4920

ctcaacttcc tcctctgtaa aacggggaca gtccctgccc ctccctacct cacaggcatg   4980

ttgtgagaat aaatgaggta acgtgtacca a                                  5011


<210>  3865
<211>  989
<212>  PRT
<213>  Homosapiens

<400>  3865

Met Lys Gly Leu Gly Asp Ser Arg Pro Arg His Leu Ser Asp Ser Leu 
1               5                   10                  15      


Asp Pro Pro His Glu Pro Leu Phe Ala Gly Thr Asp Arg Asn Pro Tyr 
            20                  25                  30          


Leu Leu Ser Pro Thr Glu Ala Phe Ala Arg Glu Ala Arg Phe Pro Gly 
        35                  40                  45              


Gln Asn Thr Leu Pro Gly Asp Gly Leu Phe Pro Leu Asn Asn Gln Leu 
    50                  55                  60                  


Pro Pro Pro Ser Ser Thr Phe Pro Arg Ile His Tyr Asn Ser His Phe 
65                  70                  75                  80  


Glu Val Pro Glu Glu Ser Pro Phe Pro Ser His Ala Gln Ala Thr Lys 
                85                  90                  95      


Ile Asn Arg Leu Pro Ala Asn Leu Leu Asp Gln Phe Glu Lys Gln Leu 
            100                 105                 110         


Pro Ile His Arg Asp Gly Phe Ser Thr Leu Gln Phe Pro Arg Gly Glu 
        115                 120                 125             


Ala Lys Ala Arg Gly Glu Ser Pro Gly Arg Ile Arg His Leu Val His 
    130                 135                 140                 


Ser Val Gln Arg Leu Phe Phe Thr Lys Ala Pro Ser Leu Glu Gly Thr 
145                 150                 155                 160 


Ala Gly Lys Val Gly Gly Asn Gly Ser Lys Lys Gly Gly Met Glu Asp 
                165                 170                 175     


Gly Lys Gly Arg Arg Ala Lys Ser Lys Glu Arg Ala Lys Ala Gly Glu 
            180                 185                 190         


Pro Lys Arg Arg Ser Arg Ser Asn Ile Ser Gly Trp Trp Ser Ser Asp 
        195                 200                 205             


Asp Asn Leu Asp Gly Glu Ala Gly Ala Phe Arg Ser Ser Gly Pro Ala 
    210                 215                 220                 


Ser Gly Leu Met Thr Leu Gly Arg Gln Ala Glu Arg Ser Gln Pro Arg 
225                 230                 235                 240 


Tyr Phe Met His Ala Tyr Asn Thr Ile Ser Gly His Met Leu Lys Thr 
                245                 250                 255     


Thr Lys Asn Asn Thr Thr Glu Leu Thr Ala Pro Pro Pro Pro Pro Ala 
            260                 265                 270         


Pro Pro Ala Thr Cys Pro Ser Leu Gly Val Gly Thr Asp Thr Asn Tyr 
        275                 280                 285             


Val Lys Arg Gly Ser Trp Ser Thr Leu Thr Leu Ser His Ala His Glu 
    290                 295                 300                 


Val Cys Gln Lys Thr Ser Ala Thr Leu Asp Lys Ser Leu Leu Lys Ser 
305                 310                 315                 320 


Lys Ser Cys His Gln Gly Leu Ala Tyr His Tyr Leu Gln Val Pro Gly 
                325                 330                 335     


Gly Gly Gly Glu Trp Ser Thr Thr Leu Leu Ser Pro Arg Glu Thr Asp 
            340                 345                 350         


Ala Ala Ala Glu Gly Pro Ile Pro Cys Arg Arg Met Arg Ser Gly Ser 
        355                 360                 365             


Tyr Ile Lys Ala Met Gly Asp Glu Asp Ser Asp Glu Ser Gly Gly Ser 
    370                 375                 380                 


Pro Lys Pro Ser Pro Lys Thr Ala Ala Arg Arg Gln Ser Tyr Leu Arg 
385                 390                 395                 400 


Ala Thr Gln Gln Ser Leu Gly Glu Gln Ser Asn Pro Arg Arg Ser Leu 
                405                 410                 415     


Asp Arg Leu Asp Ser Val Asp Met Leu Leu Pro Ser Lys Cys Pro Ser 
            420                 425                 430         


Trp Glu Glu Asp Tyr Thr Pro Val Ser Asp Ser Leu Asn Asp Ser Ser 
        435                 440                 445             


Cys Ile Ser Gln Ile Phe Gly Gln Ala Ser Leu Ile Pro Gln Leu Phe 
    450                 455                 460                 


Gly His Glu Gln Gln Val Arg Glu Ala Glu Leu Ser Asp Gln Tyr Glu 
465                 470                 475                 480 


Ala Ala Cys Glu Ser Ala Cys Ser Glu Ala Glu Ser Thr Ala Ala Glu 
                485                 490                 495     


Thr Leu Asp Leu Pro Leu Pro Ser Tyr Phe Arg Ser Arg Ser His Ser 
            500                 505                 510         


Tyr Leu Arg Ala Ile Gln Ala Gly Cys Ser Gln Glu Glu Asp Ser Val 
        515                 520                 525             


Ser Leu Gln Ser Leu Ser Pro Pro Pro Ser Thr Gly Ser Leu Ser Asn 
    530                 535                 540                 


Ser Arg Thr Leu Pro Ser Ser Ser Cys Leu Val Ala Tyr Lys Lys Thr 
545                 550                 555                 560 


Pro Pro Pro Val Pro Pro Arg Thr Thr Ser Lys Pro Phe Ile Ser Val 
                565                 570                 575     


Thr Val Gln Ser Ser Thr Glu Ser Ala Gln Asp Thr Tyr Leu Asp Ser 
            580                 585                 590         


Gln Asp His Lys Ser Glu Val Thr Ser Gln Ser Gly Leu Ser Asn Ser 
        595                 600                 605             


Ser Asp Ser Leu Asp Ser Ser Thr Arg Pro Pro Ser Val Thr Arg Gly 
    610                 615                 620                 


Gly Val Ala Pro Ala Pro Glu Ala Pro Glu Pro Pro Pro Lys His Ala 
625                 630                 635                 640 


Ala Leu Lys Ser Glu Gln Gly Thr Leu Thr Ser Ser Glu Ser His Pro 
                645                 650                 655     


Glu Ala Ala Pro Lys Arg Lys Leu Ser Ser Ile Gly Ile Gln Glu Arg 
            660                 665                 670         


Thr Arg Arg Asn Gly Ser His Leu Ser Glu Asp Asn Gly Pro Lys Ala 
        675                 680                 685             


Ile Asp Val Met Ala Pro Ser Ser Glu Ser Ser Val Pro Ser His Ser 
    690                 695                 700                 


Met Ser Ser Arg Arg Asp Thr Asp Ser Asp Thr Gln Asp Ala Asn Asp 
705                 710                 715                 720 


Ser Ser Cys Lys Ser Ser Glu Arg Ser Leu Pro Asp Cys Thr Pro His 
                725                 730                 735     


Pro Asn Ser Ile Ser Ile Asp Ala Gly Pro Arg Gln Ala Pro Lys Ile 
            740                 745                 750         


Ala Gln Ile Lys Arg Asn Leu Ser Tyr Gly Asp Asn Ser Asp Pro Ala 
        755                 760                 765             


Leu Glu Ala Ser Ser Leu Pro Pro Pro Asp Pro Trp Leu Glu Thr Ser 
    770                 775                 780                 


Ser Ser Ser Pro Ala Glu Pro Ala Gln Pro Gly Ala Cys Arg Arg Asp 
785                 790                 795                 800 


Gly Tyr Trp Phe Leu Lys Leu Leu Gln Ala Glu Thr Glu Arg Leu Glu 
                805                 810                 815     


Gly Trp Cys Cys Gln Met Asp Lys Glu Thr Lys Glu Asn Asn Leu Ser 
            820                 825                 830         


Glu Glu Val Leu Gly Lys Val Leu Ser Ala Val Gly Ser Ala Gln Leu 
        835                 840                 845             


Leu Met Ser Gln Lys Phe Gln Gln Phe Arg Gly Leu Cys Glu Gln Asn 
    850                 855                 860                 


Leu Asn Pro Asp Ala Asn Pro Arg Pro Thr Ala Gln Asp Leu Ala Gly 
865                 870                 875                 880 


Phe Trp Asp Leu Leu Gln Leu Ser Ile Glu Asp Ile Ser Met Lys Phe 
                885                 890                 895     


Asp Glu Leu Tyr His Leu Lys Ala Asn Ser Trp Gln Leu Val Glu Thr 
            900                 905                 910         


Pro Glu Lys Arg Lys Glu Glu Lys Lys Pro Pro Pro Pro Val Pro Lys 
        915                 920                 925             


Lys Pro Ala Lys Ser Lys Pro Ala Val Ser Arg Asp Lys Ala Ser Asp 
    930                 935                 940                 


Ala Ser Asp Lys Gln Arg Gln Glu Ala Arg Lys Arg Leu Leu Ala Ala 
945                 950                 955                 960 


Lys Arg Ala Ala Ser Val Arg Gln Asn Ser Ala Thr Glu Ser Ala Asp 
                965                 970                 975     


Ser Ile Glu Ile Tyr Val Pro Glu Ala Gln Thr Arg Leu 
            980                 985                 


<210>  3866
<211>  3798
<212>  DNA
<213>  Homosapiens

<400>  3866
gtccgtccgt ccgcccgccc gcccgcccgc ccgcgcttcc gtcctgtcca gccgccagtc     60

ctccagcccg tgtccccgct ccgcccgctt tgtctctccc cggctcgctg tctctttgtc    120

tctgccctcg cgctcctccg cagcccctcc ctcgctcccc atctcgggtc cccttctcag    180

agcgctcttc agccctcaga gccgcccttt ctgggcgacc ccactcttcg ggactccccc    240

tcagagcgcc cccagatctt ttggggttcc ccttgagaac accttccact ctccccaagg    300

gctccccgtg agtttcttgc acatcctttg ggggttctgc accccaagtc gctggggtct    360

cgcctcctct gaacccccat tgcccctggg ctttccctct tctgggtgtt ccccatatcc    420

actgggagct cctaggtccc aagttggggt ctttctcctt gggacccccc aatatgtcct    480

cagctccctg acttcaggag ctcctctctg ctttcccctg gtttgtcccc tgtcgctgtc    540

tctccttgtt ctctctcagg tctccgagca cccccacttc tcgggatcgg ggtcccctgc    600

tttgctctcc ctgcccctct gtgcccccac atctgtctcg gtggtctcgc cactctgtgc    660

ctcttgcgct gaaggccccc ctttgagcct gcttctttgc ctggggccct tggccccccc    720

ttgctttttc agccctagcc ccctgtctcc ccttctctct gctccttgtc tccctctccc    780

tttttctgtc tttgccgggt ctctgggtct ctgaccccca tccggccctc atggctttgt    840

gtctggagct cttgaagcaa tgttcatcat gcctagtggc gtataagaag accccgccac    900

cggtccctcc acgcaccact tcaaagccgt tcatctcagt cacagtccag agcagtactg    960

agtctgccca ggacacctac ctggacagcc aggaccacaa gagcgaggtg actagccagt   1020

cgggcctgag caactcgtcg gacagcctgg acagcagtac ccgaccgccc agcgtgacac   1080

ggggtggagt cgccccagcc cctgaggccc cagagccacc cccaaaacat gcagctctga   1140

aaagtgaaca agggacgctg accagctctg agtcccaccc cgaggccgcc cccaaaagga   1200

aactgtcatc gataggaata caagttgact gcattcagcc agtgccaaaa gaggagccca   1260

gtcccgctac caaattccag tccatcgggg ttcaggtaga ggacgactgg cgaagcagcg   1320

tcccctctca cagtatgtcc tcccgacggg acacagactc ggatacccag gatgccaatg   1380

actcaagctg taagtcatct gagaggagcc tcccggactg tacccctcac cccaactcca   1440

tcagcatcga tgccggtccc cggcaggccc ccaagattgc ccagatcaag cgcaacctct   1500

cctatggaga caacagcgac cctgccctag aggcgtcctc gctgccccca cccgacccct   1560

ggctcgagac ctcctccagc tccccagcag agccggcaca gccaggggcc tgccgccgag   1620

acggctactg gttcctaaag ctactgcagg cagaaacaga gcggctggaa ggctggtgct   1680

gccagatgga caaggagacc aaagagaaca acctctctga agaagtctta ggaaaagtcc   1740

tcagtgctgt gggcagtgcc cagctactga tgtcccagaa attccagcag ttccggggcc   1800

tctgtgagca aaacttgaac cctgatgcca acccacgccc cacagcccag gacctggcag   1860

ggttctggga cctgctacag ctgtccatcg aggatatcag catgaagttc gatgaactct   1920

accacctcaa ggccaacagc tggcagctgg tggagacccc cgagaagagg aaggaagaga   1980

agaaaccacc ccctccggtc ccaaagaagc cagccaaatc caagccggca gtgagccgcg   2040

acaaggcctc agacgccagc gacaagcagc gccaggaggc ccgcaagaga ctcctggcgg   2100

ccaagcgggc agcttctgtg cggcagaact cagccaccga gagcgcagac agcatcgaga   2160

tttatgtccc ggaggcccag accaggctct gagaccatgc aggaggaaag aaacgatttt   2220

aaatcattaa aaacacaaaa actaagtgcg aacggaacag agttttctca acctttgcta   2280

tggttattct gtctagagac cctgagccaa ctttcaaatt gacgcataca agggctcaca   2340

atttggcttt tttgggtccc tcccagcttt aggttatgaa gattttactc acaaaaaaaa   2400

tcaacaaaaa tcacgaaact agaaaacttt ttttttcctc ttgctggccg tggtggacta   2460

gatagatgga cgtcggcaac tcccggccca gcctccatac tgcggtcttt ttactcgttc   2520

tatctgatga gaactcacac tagcttgttt acaagatgac gacagtccaa gggcagcctt   2580

gggcacctgc catgtccctc ctttccccag ctatccccgc tctgaccttg attttcattc   2640

ttatgttttt ctcttttccc ttcagagctc acacagtggt caccattgtg gcaagcggct   2700

ttctgggtct cagccctctc tgcggttgag ggcccagagg acagagagat ggacatgcgt   2760

cccctccctc cccccgccaa gtgctcacac acaacctcac gcgcacacac acacacgcag   2820

atggaggcgc ctcactggga ggtgccccgc cagccctggg cagtgtcagg caggactcac   2880

tcaccgctga gcagatgagg gaagttttag tcttggcggg tggaaatgag acgaagccac   2940

agttatcaca ctccagactc ctgccctttt attttctcca gccccttctt ccttcagcaa   3000

aatctaggac tcccgagtgg cttccagggg gccgtcagtc ctcagccgcg cctgtgtccg   3060

gtgcccgagg ggcgggcggc ggtgtctgta tgtatgtgta catatgcaca tagaccttag   3120

agtgtatagt taacaaacgc ccatctgctc acccatgccc acccagcgcc gccgccgctg   3180

gctctcgggg cacctggcag gaggcgggtg tgtgaatagc atatattttt acatgtacta   3240

tatctaggtg tgtgtacaag tgtgtgtaaa aatatatacc ttgtgtgtaa gcagcccttt   3300

ttttttttgg tctccacccc cctccccccg ccccgcactc ctaagggccc atctgcccag   3360

cctctgagtt ttctgttcta tttttttttt aaccccaatt atccttctct ctctcctgcc   3420

cccgcatccc actcccaggg tgtcacgagc cctgagctgc aatggcccgg gcctgcaggg   3480

cggggtaggg gagggcaggg gctgagcccc gaagccagct cagtacctga ggggctgctc   3540

tatgctgtgt atgcgcctct ctggcatccg agacatcctc ttggctggcg cttgctgcag   3600

ggggggaccc ccccccgtcc ccaggtgaac caagggtctg ctccggggcc catttccagc   3660

ttggccgccg tctgtgacct tgggcaagtc acttgacctc tgtgtgcctc aacttcctcc   3720

tctgtaaaac ggggacagtc cctgcccctc cctacctcac aggcatgttg tgagaataaa   3780

tgaggtaacg tgtaccaa                                                 3798


<210>  3867
<211>  453
<212>  PRT
<213>  Homosapiens

<400>  3867

Met Ala Leu Cys Leu Glu Leu Leu Lys Gln Cys Ser Ser Cys Leu Val 
1               5                   10                  15      


Ala Tyr Lys Lys Thr Pro Pro Pro Val Pro Pro Arg Thr Thr Ser Lys 
            20                  25                  30          


Pro Phe Ile Ser Val Thr Val Gln Ser Ser Thr Glu Ser Ala Gln Asp 
        35                  40                  45              


Thr Tyr Leu Asp Ser Gln Asp His Lys Ser Glu Val Thr Ser Gln Ser 
    50                  55                  60                  


Gly Leu Ser Asn Ser Ser Asp Ser Leu Asp Ser Ser Thr Arg Pro Pro 
65                  70                  75                  80  


Ser Val Thr Arg Gly Gly Val Ala Pro Ala Pro Glu Ala Pro Glu Pro 
                85                  90                  95      


Pro Pro Lys His Ala Ala Leu Lys Ser Glu Gln Gly Thr Leu Thr Ser 
            100                 105                 110         


Ser Glu Ser His Pro Glu Ala Ala Pro Lys Arg Lys Leu Ser Ser Ile 
        115                 120                 125             


Gly Ile Gln Val Asp Cys Ile Gln Pro Val Pro Lys Glu Glu Pro Ser 
    130                 135                 140                 


Pro Ala Thr Lys Phe Gln Ser Ile Gly Val Gln Val Glu Asp Asp Trp 
145                 150                 155                 160 


Arg Ser Ser Val Pro Ser His Ser Met Ser Ser Arg Arg Asp Thr Asp 
                165                 170                 175     


Ser Asp Thr Gln Asp Ala Asn Asp Ser Ser Cys Lys Ser Ser Glu Arg 
            180                 185                 190         


Ser Leu Pro Asp Cys Thr Pro His Pro Asn Ser Ile Ser Ile Asp Ala 
        195                 200                 205             


Gly Pro Arg Gln Ala Pro Lys Ile Ala Gln Ile Lys Arg Asn Leu Ser 
    210                 215                 220                 


Tyr Gly Asp Asn Ser Asp Pro Ala Leu Glu Ala Ser Ser Leu Pro Pro 
225                 230                 235                 240 


Pro Asp Pro Trp Leu Glu Thr Ser Ser Ser Ser Pro Ala Glu Pro Ala 
                245                 250                 255     


Gln Pro Gly Ala Cys Arg Arg Asp Gly Tyr Trp Phe Leu Lys Leu Leu 
            260                 265                 270         


Gln Ala Glu Thr Glu Arg Leu Glu Gly Trp Cys Cys Gln Met Asp Lys 
        275                 280                 285             


Glu Thr Lys Glu Asn Asn Leu Ser Glu Glu Val Leu Gly Lys Val Leu 
    290                 295                 300                 


Ser Ala Val Gly Ser Ala Gln Leu Leu Met Ser Gln Lys Phe Gln Gln 
305                 310                 315                 320 


Phe Arg Gly Leu Cys Glu Gln Asn Leu Asn Pro Asp Ala Asn Pro Arg 
                325                 330                 335     


Pro Thr Ala Gln Asp Leu Ala Gly Phe Trp Asp Leu Leu Gln Leu Ser 
            340                 345                 350         


Ile Glu Asp Ile Ser Met Lys Phe Asp Glu Leu Tyr His Leu Lys Ala 
        355                 360                 365             


Asn Ser Trp Gln Leu Val Glu Thr Pro Glu Lys Arg Lys Glu Glu Lys 
    370                 375                 380                 


Lys Pro Pro Pro Pro Val Pro Lys Lys Pro Ala Lys Ser Lys Pro Ala 
385                 390                 395                 400 


Val Ser Arg Asp Lys Ala Ser Asp Ala Ser Asp Lys Gln Arg Gln Glu 
                405                 410                 415     


Ala Arg Lys Arg Leu Leu Ala Ala Lys Arg Ala Ala Ser Val Arg Gln 
            420                 425                 430         


Asn Ser Ala Thr Glu Ser Ala Asp Ser Ile Glu Ile Tyr Val Pro Glu 
        435                 440                 445             


Ala Gln Thr Arg Leu 
    450             


<210>  3868
<211>  1212
<212>  DNA
<213>  Homosapiens

<400>  3868
ggagtccaga cccgacggcc ggcccagttc cacgcaccca gcgagcccaa gcgccttctc     60

cgcaccaggg aagccccacc caccagaagc caagatgtcc agcaagcggg ccaaagccaa    120

gaccaccaag aagcggccac agcgggccac atccaatgtc ttcgcaatgt ttgaccagtc    180

ccagatccag gagtttaagg aggctttcaa catgattgac cagaaccgtg atggcttcat    240

tgacaaggag gacctgcacg acatgctggc ctcgctgggg aagaacccca cagacgaata    300

cctggagggc atgatgagcg aggccccggg gcccatcaac ttcaccatgt tcctcaccat    360

gtttggggag aagctgaacg gcacggaccc cgaggatgtg attcgcaacg cctttgcctg    420

cttcgacgag gaagcctcag gtttcatcca tgaggaccac ctccgggagc tgctcaccac    480

catgggtgac cgcttcacag atgaggaagt ggacgagatg taccgggagg cacccattga    540

taagaaaggc aacttcaact acgtggagtt cacccgcatc ctcaaacatg gcgccaagga    600

taaagacgac taggccaccc cagccccctg acaccccagc ccccgccagt cacccctccc    660

cgcacacacc cgtccatacc agctccctgc ccatgaccct cgctcaggga tccccctttg    720

aggggttagg gtcccagttc ccagtggaag aaacaggcca ggagaagtgc gtgccgagct    780

gaggcagatg ttcccacagt gaccccagag ccctgggcta tagtctctga cccctccaag    840

gaaagaccac cttctgggga catgggctgg agggcaggac ctagaggcac caagggaagg    900

ccccattccg gggctgttcc ccgaggagga agggaagggg ctctgtgtgc cccccaggag    960

gaagaggccc tgagtcctgg gatcagacac cccttcacgt gtatccccac acaaatgcaa   1020

gctcaccaag gtcccctctc agtccccttc cctacaccct gaccggccac tgccgcacac   1080

ccacccagag cacgccaccc gccatgggag tgtgctcagg agtcgcgggc agcgtggaca   1140

tctgtcccag agggggcaga atctccaata gaggactgag cactgctaaa aaaaaaaaaa   1200

aaaaaaaaaa aa                                                       1212


<210>  3869
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  3869

Met Ser Ser Lys Arg Ala Lys Ala Lys Thr Thr Lys Lys Arg Pro Gln 
1               5                   10                  15      


Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln 
            20                  25                  30          


Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe 
        35                  40                  45              


Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn 
    50                  55                  60                  


Pro Thr Asp Glu Tyr Leu Glu Gly Met Met Ser Glu Ala Pro Gly Pro 
65                  70                  75                  80  


Ile Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly 
                85                  90                  95      


Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu 
            100                 105                 110         


Glu Ala Ser Gly Phe Ile His Glu Asp His Leu Arg Glu Leu Leu Thr 
        115                 120                 125             


Thr Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Met Tyr Arg 
    130                 135                 140                 


Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Val Glu Phe Thr 
145                 150                 155                 160 


Arg Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                165                 170         


<210>  3870
<211>  1044
<212>  DNA
<213>  Homosapiens

<400>  3870
ggagtccaga cccgacggcc ggcccagttc cacgcaccca gcgagcccaa gcgccttctc     60

cgcaccaggg aagccccacc caccagaagc caagatgtcc agcaagcggg ccaaagccaa    120

gaccaccaag aagcggccac agcgggccac atccaatgtc ttcgcaatgt ttgaccagtc    180

ccagatccag gagtttaagg aggctttcaa catgattgac cagaaccgtg atggcttcat    240

tgacaaggag gacctgcacg acatgctggc ctcgctgggt ttcatccatg aggaccacct    300

ccgggagctg ctcaccacca tgggtgaccg cttcacagat gaggaagtgg acgagatgta    360

ccgggaggca cccattgata agaaaggcaa cttcaactac gtggagttca cccgcatcct    420

caaacatggc gccaaggata aagacgacta ggccacccca gccccctgac accccagccc    480

ccgccagtca cccctccccg cacacacccg tccataccag ctccctgccc atgaccctcg    540

ctcagggatc cccctttgag gggttagggt cccagttccc agtggaagaa acaggccagg    600

agaagtgcgt gccgagctga ggcagatgtt cccacagtga ccccagagcc ctgggctata    660

gtctctgacc cctccaagga aagaccacct tctggggaca tgggctggag ggcaggacct    720

agaggcacca agggaaggcc ccattccggg gctgttcccc gaggaggaag ggaaggggct    780

ctgtgtgccc cccaggagga agaggccctg agtcctggga tcagacaccc cttcacgtgt    840

atccccacac aaatgcaagc tcaccaaggt cccctctcag tccccttccc tacaccctga    900

ccggccactg ccgcacaccc acccagagca cgccacccgc catgggagtg tgctcaggag    960

tcgcgggcag cgtggacatc tgtcccagag ggggcagaat ctccaataga ggactgagca   1020

ctgctaaaaa aaaaaaaaaa aaaa                                          1044


<210>  3871
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  3871

Met Ser Ser Lys Arg Ala Lys Ala Lys Thr Thr Lys Lys Arg Pro Gln 
1               5                   10                  15      


Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln 
            20                  25                  30          


Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe 
        35                  40                  45              


Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Phe Ile 
    50                  55                  60                  


His Glu Asp His Leu Arg Glu Leu Leu Thr Thr Met Gly Asp Arg Phe 
65                  70                  75                  80  


Thr Asp Glu Glu Val Asp Glu Met Tyr Arg Glu Ala Pro Ile Asp Lys 
                85                  90                  95      


Lys Gly Asn Phe Asn Tyr Val Glu Phe Thr Arg Ile Leu Lys His Gly 
            100                 105                 110         


Ala Lys Asp Lys Asp Asp 
        115             


<210>  3872
<211>  3425
<212>  DNA
<213>  Homosapiens

<400>  3872
gcgagctgtc aggccgagtg tcaggccggg caggtacgcg gcgcgcgccc ccggcgcccc     60

ccgctccccg ccgggacgcc ccgcgccgag ccggaggccg cgtggacccg aaagccgctg    120

ggaaaagttt acccaaggtc cagcctagcc cctaggcacc atgtcggaca gtgatctagg    180

tgaggacgaa ggcctcctct ccctggcggg caaaaggaag cgcaggggga acctgcccaa    240

ggagtcggtg aagatcctcc gggactggct gtacttgcac cgctacaacg cctacccctc    300

agagcaggag aagctgagcc tttctggaca gaccaacctg tcagtgctgc aaatatgtaa    360

ctggttcatc aatgcccggc ggcggcttct cccagacatg cttcggaagg atggcaaaga    420

ccctaatcag tttaccattt cccgccgcgg gggtaaggcc tcagatgtgg ccctcccccg    480

tggcagcagc ccctcagtgc tggctgtgtc tgtcccagcc cccaccaatg tgctctccct    540

gtctgtgtgc tccatgccgc ttcactcagg ccagggggaa aagccagcag cccctttccc    600

acgtggggag ctggagtctc ccaagcccct ggtgacccct ggtagcacac ttactctgct    660

gaccagggct gaggctggaa gccccacagg tggactcttc aacacgccac cacccacacc    720

cccagagcag gacaaagagg acttcagcag cttccagctg ctggtggagg tggcgctaca    780

gagggctgct gagatggagc ttcagaagca gcaggaccca tcactcccat tactgcacac    840

tcccatccct ttagtctctg aaaatcccca gtaggcatct gccaagaagg gtgctgaagg    900

ctccagccag ctgtcctggg tttccgtttt ggttcccttt catacagagg gttttctatg    960

gatcactgcc aaacattggg atcatctcct ctgtccagag gtcttcaaca ggaagatgcc   1020

agctggcacc actgcactgt gatgggggcc ctctcctctg ctgactctgc cgtttctcca   1080

ggcctccgct cagtgatgag accaagagat cggagacaag catggtgctg ctgcttctgc   1140

tgcttctcca gaaaatccct gggacacctt tgttccagcc tggtttcctg ggctgggctc   1200

aggaaagctg ccaaattcag tcctatgttg ggtccaagct gcccctgtgc tgtttctgtc   1260

aagccaggtg tggacattcc aagttcatat gcgtgaacaa aagaaaagag gaacccagtg   1320

gatgtaacag aaccgactcc agttgaatgt ttagattttt gctaaactgt tttctttttc   1380

ccttttttgc tgtggtttgc attcacggca gtagttagcc caggtgtggg gaacgagagt   1440

gcactgcatg atagcgttct ggtgagctgg gaaggaccca ccactgccac tgaggattgt   1500

tttggaagaa aggaatattt ttatcttggg gaccagctaa gtctctgcag tagtgtgaaa   1560

ttccaaatgg ttgttttatc attggtttgg tttaccaaaa aaaaggcagg gaaaaaaaaa   1620

aaaaacaacc gtatgagcgc attggcttgt ctgccgcagg cacagaaggg tagaaagcca   1680

cagcaggggg cagtccagca gactctgact caactttcta ggcacctagc agagaaagat   1740

aagatcaaaa ggtgtttggt ttttctttta atttttattg tagttttttt gggtgggtgg   1800

gggaagtaaa ctagactgaa gcgatggatt ttttttttct tttttttctt tagtgttttt   1860

ccctttgttc ttgaacactt ttgccctgca gcctcagttt tgaattcttt tagcaacttg   1920

gattagaggg gcccatatgt cagaagctcc cagcacctcc tacttgggag aaaagtgagc   1980

catctgctgg tcaggaagtc ctccagagag gcagcttttc ccacaatggt ggcaggaaac   2040

tttggggaaa gcaggaatgg tgtccactgc tgcggaggaa ctgccttcag agaaggtggg   2100

gctggaaaag ggttagaagc ctcctagctg ggattgtctt tgtttcacct ttctttaaat   2160

tagaattaca gaagcccctg cccagtgaac agataacaat tggtcttatg ctcctccctt   2220

tcccccattt tttcttttgc tgttttgttt tttgtttttt gtttgtttgt ttgttttttt   2280

gagacagagt catgctctgt cacccgggct ggagtgcagt ggtgcgatct cagctcactg   2340

taacctccgc ctcccgggtt caagcaatta tttgcctcag cctcccgagt agctgggatt   2400

ataggcaccc gccaccatgt ctggctttta gtagagacgg ggtttcacca tcttggccag   2460

gctggtcttg gaactcctga cctcgtgagc caccacgccc agcctctttt gctgtttcat   2520

tgctgacagt gttcaacaat atgccccatc tttatatatc ctaagaaaca ctaatcctag   2580

gttattgcta gccaaaatat ttttgtcctg agtagtgtca ctgggccaaa agatagatca   2640

ggacgacagc ctttagtttt cctgaaatca ccaggtcagg cacaaggaga aaaggttcct   2700

ggatactgac taacttgggt gggtctagcc aggagaaaga cagtaacatg tgttctgtac   2760

tttctgggaa gatccctgaa gccatcacag aggctcccca acttctgagt cgcccatctg   2820

ttgctgtggg agtgtgaacg gatcgctgaa ggagagggag ctttgctctc tctaggtggg   2880

caagtttcct gggctctctg tgttgcctcc ctctggcttc ttcctcccgt gccctctccc   2940

cgtgtgcccc agggggatca gggatcctca ccctcctgag gcccagtggg gaagaatgaa   3000

catggcttca tccaggttaa ctgatgctgc catttgccca gcctcttcca tcccagccct   3060

gtcagtgagc ccaggtctgg tgcaactgct gcaggatgcc tgtagtaggg aactctggaa   3120

gtgtattggg ctgaggtggg attttccctc cccacagtgc actgagcaat ggagggtggt   3180

gagggagcca tgctgctgaa ttctggttgg catttcccca ttatgtaaaa tggggtgttg   3240

ggtagggcag actctgcttg ggtttggttg taagataaac ctggaggaga agcacagttg   3300

tcccattgaa ttatttgagc aaaaactact gtaaataact tttttgtctt ttgtcaaata   3360

aaattttttt ttgttttttt aagcagaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3420

aaaaa                                                               3425


<210>  3873
<211>  237
<212>  PRT
<213>  Homosapiens

<400>  3873

Met Ser Asp Ser Asp Leu Gly Glu Asp Glu Gly Leu Leu Ser Leu Ala 
1               5                   10                  15      


Gly Lys Arg Lys Arg Arg Gly Asn Leu Pro Lys Glu Ser Val Lys Ile 
            20                  25                  30          


Leu Arg Asp Trp Leu Tyr Leu His Arg Tyr Asn Ala Tyr Pro Ser Glu 
        35                  40                  45              


Gln Glu Lys Leu Ser Leu Ser Gly Gln Thr Asn Leu Ser Val Leu Gln 
    50                  55                  60                  


Ile Cys Asn Trp Phe Ile Asn Ala Arg Arg Arg Leu Leu Pro Asp Met 
65                  70                  75                  80  


Leu Arg Lys Asp Gly Lys Asp Pro Asn Gln Phe Thr Ile Ser Arg Arg 
                85                  90                  95      


Gly Gly Lys Ala Ser Asp Val Ala Leu Pro Arg Gly Ser Ser Pro Ser 
            100                 105                 110         


Val Leu Ala Val Ser Val Pro Ala Pro Thr Asn Val Leu Ser Leu Ser 
        115                 120                 125             


Val Cys Ser Met Pro Leu His Ser Gly Gln Gly Glu Lys Pro Ala Ala 
    130                 135                 140                 


Pro Phe Pro Arg Gly Glu Leu Glu Ser Pro Lys Pro Leu Val Thr Pro 
145                 150                 155                 160 


Gly Ser Thr Leu Thr Leu Leu Thr Arg Ala Glu Ala Gly Ser Pro Thr 
                165                 170                 175     


Gly Gly Leu Phe Asn Thr Pro Pro Pro Thr Pro Pro Glu Gln Asp Lys 
            180                 185                 190         


Glu Asp Phe Ser Ser Phe Gln Leu Leu Val Glu Val Ala Leu Gln Arg 
        195                 200                 205             


Ala Ala Glu Met Glu Leu Gln Lys Gln Gln Asp Pro Ser Leu Pro Leu 
    210                 215                 220                 


Leu His Thr Pro Ile Pro Leu Val Ser Glu Asn Pro Gln 
225                 230                 235         


<210>  3874
<211>  1091
<212>  DNA
<213>  Homosapiens

<400>  3874
cgcggcgcct gctctgtaga gccggcggaa ccgggtagct tggccaggtt gtgaggaacc     60

gcagcgcgcc gcaggaccgg gccgctgagc ctgcagccgc cccgcgccgt gacctgcgac    120

cctagacccc gactcccttt ggctcagccc gcgcgcccca ggcccggccc gggcggcgcg    180

acgggaggat gagcggcggg cggcggaagg aggagccgcc tcagccgcag ctggccaacg    240

gggccctcaa agtctccgtc tggagtaagg tgctgcggag cgacgcggcc tgggaggata    300

aggatgaatt tttagatgtg atctactggt tccgacagat cattgctgtg gtcctgggtg    360

tcatttgggg agttttgcca ttacgagggt tcttgggaat agcaggattc tgcctgatca    420

atgcaggagt cctgtacctc tacttcagca attacctaca gattgatgag gaagaatatg    480

gtggcacgtg ggagctcacg aaggaagggt ttatgacctc ttttgccttg ttcatggtca    540

tttggatcat cttttacact gccatccatt atgactgatg gtgtacagct cccaagtgct    600

ccctatccag tccaaaggac cctcttgatt acagcacagg aacttgatcg ttggggaacc    660

ccagcccctt ggaacttgga agacccgtgt ttcctggacc gcgaatcagt gtgttgggca    720

tcagtgtttt ctgcaagggt tgtgacctga aactttttaa aaaccaccca cctttgggga    780

agcatttctg aatttatcca tcaccaacca tttcttcttg gataccatca agtaacagct    840

attatttgcc aagtggagct gtcatttaat ttgatgcacc tctggattca gatgaaacat    900

taaattgtct tcctcgattc tccatcgggt gtagagtttt taaactatca atggcatttc    960

aagtcttctg aaacagcatg gctgtatgtg cgtggtccat agcacagtac atgcagcatc   1020

taataagagt ttccattgta gaatgttttc acatacttga ataaatcaaa tctttaattg   1080

agaaaaaaaa a                                                        1091


<210>  3875
<211>  129
<212>  PRT
<213>  Homosapiens

<400>  3875

Met Ser Gly Gly Arg Arg Lys Glu Glu Pro Pro Gln Pro Gln Leu Ala 
1               5                   10                  15      


Asn Gly Ala Leu Lys Val Ser Val Trp Ser Lys Val Leu Arg Ser Asp 
            20                  25                  30          


Ala Ala Trp Glu Asp Lys Asp Glu Phe Leu Asp Val Ile Tyr Trp Phe 
        35                  40                  45              


Arg Gln Ile Ile Ala Val Val Leu Gly Val Ile Trp Gly Val Leu Pro 
    50                  55                  60                  


Leu Arg Gly Phe Leu Gly Ile Ala Gly Phe Cys Leu Ile Asn Ala Gly 
65                  70                  75                  80  


Val Leu Tyr Leu Tyr Phe Ser Asn Tyr Leu Gln Ile Asp Glu Glu Glu 
                85                  90                  95      


Tyr Gly Gly Thr Trp Glu Leu Thr Lys Glu Gly Phe Met Thr Ser Phe 
            100                 105                 110         


Ala Leu Phe Met Val Ile Trp Ile Ile Phe Tyr Thr Ala Ile His Tyr 
        115                 120                 125             


Asp 
    


<210>  3876
<211>  961
<212>  DNA
<213>  Homosapiens

<400>  3876
cgcggcgcct gctctgtaga gccggcggaa ccgggtagct tggccaggtt gtgaggaacc     60

gcagcgcgcc gcaggaccgg gccgctgagc ctgcagccgc cccgcgccgt gacctgcgac    120

cctagacccc gactcccttt ggctcagccc gcgcgcccca ggcccggccc gggcggcgcg    180

acgggaggat gagcggcggg cggcggaagg aggagccgcc tcagccgcag ctggccaacg    240

gggccctcaa agtctccgtc tggagtaagg tgctgcggag cgacgcggcc tgggaggata    300

aggatgaatt tttagatgtg atctactggt tccgacagat cattgctgtg gtcctgggtg    360

tcatttgggg agttttgcca ttacgagggt tcttgggaat agcagggtca tttggatcat    420

cttttacact gccatccatt atgactgatg gtgtacagct cccaagtgct ccctatccag    480

tccaaaggac cctcttgatt acagcacagg aacttgatcg ttggggaacc ccagcccctt    540

ggaacttgga agacccgtgt ttcctggacc gcgaatcagt gtgttgggca tcagtgtttt    600

ctgcaagggt tgtgacctga aactttttaa aaaccaccca cctttgggga agcatttctg    660

aatttatcca tcaccaacca tttcttcttg gataccatca agtaacagct attatttgcc    720

aagtggagct gtcatttaat ttgatgcacc tctggattca gatgaaacat taaattgtct    780

tcctcgattc tccatcgggt gtagagtttt taaactatca atggcatttc aagtcttctg    840

aaacagcatg gctgtatgtg cgtggtccat agcacagtac atgcagcatc taataagagt    900

ttccattgta gaatgttttc acatacttga ataaatcaaa tctttaattg agaaaaaaaa    960

a                                                                    961


<210>  3877
<211>  143
<212>  PRT
<213>  Homosapiens

<400>  3877

Met Ser Gly Gly Arg Arg Lys Glu Glu Pro Pro Gln Pro Gln Leu Ala 
1               5                   10                  15      


Asn Gly Ala Leu Lys Val Ser Val Trp Ser Lys Val Leu Arg Ser Asp 
            20                  25                  30          


Ala Ala Trp Glu Asp Lys Asp Glu Phe Leu Asp Val Ile Tyr Trp Phe 
        35                  40                  45              


Arg Gln Ile Ile Ala Val Val Leu Gly Val Ile Trp Gly Val Leu Pro 
    50                  55                  60                  


Leu Arg Gly Phe Leu Gly Ile Ala Gly Ser Phe Gly Ser Ser Phe Thr 
65                  70                  75                  80  


Leu Pro Ser Ile Met Thr Asp Gly Val Gln Leu Pro Ser Ala Pro Tyr 
                85                  90                  95      


Pro Val Gln Arg Thr Leu Leu Ile Thr Ala Gln Glu Leu Asp Arg Trp 
            100                 105                 110         


Gly Thr Pro Ala Pro Trp Asn Leu Glu Asp Pro Cys Phe Leu Asp Arg 
        115                 120                 125             


Glu Ser Val Cys Trp Ala Ser Val Phe Ser Ala Arg Val Val Thr 
    130                 135                 140             


<210>  3878
<211>  2497
<212>  DNA
<213>  Homosapiens

<400>  3878
gtgacagagc tcaaagggcc ctgggccttc cctccctggc tcggctgtgc ttgggagggt     60

tccccagtcc agaatcccta aggagaatgg ggcagctgat ccatccctgg tgtacaaact    120

gctgactgca gacagatgct gagctaccca aaccaacacc tagcctctcc ctgaagatcc    180

tcccaggctg agagagttct gggtgtccta ggaccaagga cactggcaga cttccagaag    240

ggcccccaaa gccctaacct gtccagccag agcatgcgtc tcagcagagc tgtcttccca    300

agcctttgat gacaaaccaa tttccctcga tgatgtgctt ctgagtgctc tgctgaggaa    360

caatgggaag tctgcccagc agaagaaaat ctctgccaag cccaagcttg agttcctctg    420

tccaaggcca gggacctgtg accatggaag cagagagaag caaggccaca gccgtggccc    480

tgggcagttt cccggcaggt ggcccggccg agctgtcgct gagactcggg gagccattga    540

ccatcgtctc tgaggatgga gactggtgga cggtgctgtc tgaagtctca ggcagagagt    600

ataacatccc cagcgtccac gtggccaaag tctcccatgg gtggctgtat gagggcctga    660

gcagggagaa agcagaggaa ctgctgttgt tacctgggaa ccctggaggg gccttcctca    720

tccgggagag ccagaccagg agaggctctt actctctgtc agtccgcctc agccgccctg    780

catcctggga ccggatcaga cactacagga tccactgcct tgacaatggc tggctgtaca    840

tctcaccgcg cctcaccttc ccctcactcc aggccctggt ggaccattac tctgagctgg    900

cggatgacat ctgctgccta ctcaaggagc cctgtgtcct gcagagggct ggcccgctcc    960

ctggcaagga tataccccta cctgtgactg tgcagaggac accactcaac tggaaagagc   1020

tggacagctc cctcctgttt tctgaagctg ccacagggga ggagtctctt ctcagtgagg   1080

gtctccggga gtccctcagc ttctacatca gcctgaatga cgaggctgtc tctttggatg   1140

atgcctaggc ccaaaggaga ggccaaaagg gaaaccaagg ctgcacacct agaaccccaa   1200

ttcagcctcc tgggcacccc agaggcaagg ctgtgcactc agggagggag ggtgggacac   1260

agaggtgcat ctagggtccc acctgtaccc ttgctctttc ctctcttagc ccttagaagt   1320

cacctacttc cttccagtgc catgatccca cctgcgacct ctagtgcgag tgcagagaag   1380

gtgggaccag ggccagggtt ccaaaaagag aataagcctc ctggggggtc tgacctagtt   1440

agttcttgag tttggggttt ccagtaccat ctggatgccc tgcctgttga gccccattct   1500

acatccccac cattaaccag gccccaccca caaggtagaa acaaccccta gagtcaacga   1560

gaaagtcatt ttcagaaaat ctacaagtct cgttgagacc accaccatac ctcagaaggt   1620

aggactgtgg cctagaaggg aaaggaaagc tgagatgatg tcttaccgta gcagcagatc   1680

ttggatggtc caggctctat gtgacctcca gagcaaagag aaagacttcg gacagtctag   1740

gtcctcaaat gtcccccatt gaggacaaca gccccagctc tttttctttt ttttgagacg   1800

gagtcttgcc ctgttgccca tgctggagtg caatggcacg atctcagctc actgcaacct   1860

ccatctcctg gattcaaaca attctcctgc ctcagcctcc agaatagctg ggattacagg   1920

cgtacaccac catgcctggc taattttttt gtatttttag tagacatggg gtttcaccac   1980

attggccagg ctggtgtcga actcctgacc tcaggtgatc cacccacctt ggcctcccaa   2040

agtgctggga ttacaggtgt gagccacggc acccagccta gctctcagat ctctatttca   2100

ttttgtggct taccattccc tagcacactg gccttgccat cttgtggccg aataaaaaat   2160

aacacctctt aagtctagca cactgcagtg aggccaggca cctcagtgct gggcaggggc   2220

atcagaaggt gctaagccct ctctccacaa tgccaagacg gagaccacag cctacaccaa   2280

atccagccct tgatttccct gctgcctcca taaacagaaa gaggtctgct ggatccgcta   2340

agggatcagg gagaggaaga aagagggatg gggtgggagg caccccctcc agtgctccta   2400

ctggttccca agctacaggt ggggtgggaa aggctttatc aggtatcatc aacaggttct   2460

caattaaaga tttgatttat tcaagtatgt gaaaaaa                            2497


<210>  3879
<211>  261
<212>  PRT
<213>  Homosapiens

<400>  3879

Met Gly Ser Leu Pro Ser Arg Arg Lys Ser Leu Pro Ser Pro Ser Leu 
1               5                   10                  15      


Ser Ser Ser Val Gln Gly Gln Gly Pro Val Thr Met Glu Ala Glu Arg 
            20                  25                  30          


Ser Lys Ala Thr Ala Val Ala Leu Gly Ser Phe Pro Ala Gly Gly Pro 
        35                  40                  45              


Ala Glu Leu Ser Leu Arg Leu Gly Glu Pro Leu Thr Ile Val Ser Glu 
    50                  55                  60                  


Asp Gly Asp Trp Trp Thr Val Leu Ser Glu Val Ser Gly Arg Glu Tyr 
65                  70                  75                  80  


Asn Ile Pro Ser Val His Val Ala Lys Val Ser His Gly Trp Leu Tyr 
                85                  90                  95      


Glu Gly Leu Ser Arg Glu Lys Ala Glu Glu Leu Leu Leu Leu Pro Gly 
            100                 105                 110         


Asn Pro Gly Gly Ala Phe Leu Ile Arg Glu Ser Gln Thr Arg Arg Gly 
        115                 120                 125             


Ser Tyr Ser Leu Ser Val Arg Leu Ser Arg Pro Ala Ser Trp Asp Arg 
    130                 135                 140                 


Ile Arg His Tyr Arg Ile His Cys Leu Asp Asn Gly Trp Leu Tyr Ile 
145                 150                 155                 160 


Ser Pro Arg Leu Thr Phe Pro Ser Leu Gln Ala Leu Val Asp His Tyr 
                165                 170                 175     


Ser Glu Leu Ala Asp Asp Ile Cys Cys Leu Leu Lys Glu Pro Cys Val 
            180                 185                 190         


Leu Gln Arg Ala Gly Pro Leu Pro Gly Lys Asp Ile Pro Leu Pro Val 
        195                 200                 205             


Thr Val Gln Arg Thr Pro Leu Asn Trp Lys Glu Leu Asp Ser Ser Leu 
    210                 215                 220                 


Leu Phe Ser Glu Ala Ala Thr Gly Glu Glu Ser Leu Leu Ser Glu Gly 
225                 230                 235                 240 


Leu Arg Glu Ser Leu Ser Phe Tyr Ile Ser Leu Asn Asp Glu Ala Val 
                245                 250                 255     


Ser Leu Asp Asp Ala 
            260     


<210>  3880
<211>  2447
<212>  DNA
<213>  Homosapiens

<400>  3880
gtgacagagc tcaaagggcc ctgggccttc cctccctggc tcggctgtgc ttgggagggt     60

tccccagtcc agaatcccta aggagaatgg ggcagctgat ccatccctgg tgtacaaact    120

gctgactgca gacagatgct gagctaccca aaccaacacc tagcctctcc ctgaagatcc    180

tcccaggctg agagagttct gggtgtccta ggaccaagga cactggcaga cttccagaag    240

ggcccccaaa gccctaacct gtccagccag agcatgcgtc tcagcagagc tgtcttccca    300

agcctttgat gacaaaccaa tttccctcga tgatgtgctt ctgagtgctc tgctgaggaa    360

caatgggaag tctgcccagc agaagaaaat ctctgccaag cccaagcttg agttcctctg    420

tccaaggcca gggacctgtg accatggaag cagagagaag caaggccaca gccgtggccc    480

tgggcagttt cccggcaggt ggcccggccg agctgtcgct gagactcggg gagccattga    540

ccatcgtctc tgaggatgga gactggtgga cggtgctgtc tgaagtctca ggcagagagt    600

ataacatccc cagcgtccac gtggccaaag tctcccatgg gtggctgtat gagggcctga    660

gcagggagaa agcagaggaa ctgctgttgt tacctgggaa ccctggaggg gccttcctca    720

tccgggagag ccagaccagg agaggctctt actctctgtc agtccgcctc agccgccctg    780

catcctggga ccggatcaga cactacagga tccactgcct tgacaatggc tggctgtaca    840

tctcaccgcg cctcaccttc ccctcactcc aggccctggt ggaccattac tctgagggct    900

ggcccgctcc ctggcaagga tataccccta cctgtgactg tgcagaggac accactcaac    960

tggaaagagc tggacagctc cctcctgttt tctgaagctg ccacagggga ggagtctctt   1020

ctcagtgagg gtctccggga gtccctcagc ttctacatca gcctgaatga cgaggctgtc   1080

tctttggatg atgcctaggc ccaaaggaga ggccaaaagg gaaaccaagg ctgcacacct   1140

agaaccccaa ttcagcctcc tgggcacccc agaggcaagg ctgtgcactc agggagggag   1200

ggtgggacac agaggtgcat ctagggtccc acctgtaccc ttgctctttc ctctcttagc   1260

ccttagaagt cacctacttc cttccagtgc catgatccca cctgcgacct ctagtgcgag   1320

tgcagagaag gtgggaccag ggccagggtt ccaaaaagag aataagcctc ctggggggtc   1380

tgacctagtt agttcttgag tttggggttt ccagtaccat ctggatgccc tgcctgttga   1440

gccccattct acatccccac cattaaccag gccccaccca caaggtagaa acaaccccta   1500

gagtcaacga gaaagtcatt ttcagaaaat ctacaagtct cgttgagacc accaccatac   1560

ctcagaaggt aggactgtgg cctagaaggg aaaggaaagc tgagatgatg tcttaccgta   1620

gcagcagatc ttggatggtc caggctctat gtgacctcca gagcaaagag aaagacttcg   1680

gacagtctag gtcctcaaat gtcccccatt gaggacaaca gccccagctc tttttctttt   1740

ttttgagacg gagtcttgcc ctgttgccca tgctggagtg caatggcacg atctcagctc   1800

actgcaacct ccatctcctg gattcaaaca attctcctgc ctcagcctcc agaatagctg   1860

ggattacagg cgtacaccac catgcctggc taattttttt gtatttttag tagacatggg   1920

gtttcaccac attggccagg ctggtgtcga actcctgacc tcaggtgatc cacccacctt   1980

ggcctcccaa agtgctggga ttacaggtgt gagccacggc acccagccta gctctcagat   2040

ctctatttca ttttgtggct taccattccc tagcacactg gccttgccat cttgtggccg   2100

aataaaaaat aacacctctt aagtctagca cactgcagtg aggccaggca cctcagtgct   2160

gggcaggggc atcagaaggt gctaagccct ctctccacaa tgccaagacg gagaccacag   2220

cctacaccaa atccagccct tgatttccct gctgcctcca taaacagaaa gaggtctgct   2280

ggatccgcta agggatcagg gagaggaaga aagagggatg gggtgggagg caccccctcc   2340

agtgctccta ctggttccca agctacaggt ggggtgggaa aggctttatc aggtatcatc   2400

aacaggttct caattaaaga tttgatttat tcaagtatgt gaaaaaa                 2447


<210>  3881
<211>  210
<212>  PRT
<213>  Homosapiens

<400>  3881

Met Gly Ser Leu Pro Ser Arg Arg Lys Ser Leu Pro Ser Pro Ser Leu 
1               5                   10                  15      


Ser Ser Ser Val Gln Gly Gln Gly Pro Val Thr Met Glu Ala Glu Arg 
            20                  25                  30          


Ser Lys Ala Thr Ala Val Ala Leu Gly Ser Phe Pro Ala Gly Gly Pro 
        35                  40                  45              


Ala Glu Leu Ser Leu Arg Leu Gly Glu Pro Leu Thr Ile Val Ser Glu 
    50                  55                  60                  


Asp Gly Asp Trp Trp Thr Val Leu Ser Glu Val Ser Gly Arg Glu Tyr 
65                  70                  75                  80  


Asn Ile Pro Ser Val His Val Ala Lys Val Ser His Gly Trp Leu Tyr 
                85                  90                  95      


Glu Gly Leu Ser Arg Glu Lys Ala Glu Glu Leu Leu Leu Leu Pro Gly 
            100                 105                 110         


Asn Pro Gly Gly Ala Phe Leu Ile Arg Glu Ser Gln Thr Arg Arg Gly 
        115                 120                 125             


Ser Tyr Ser Leu Ser Val Arg Leu Ser Arg Pro Ala Ser Trp Asp Arg 
    130                 135                 140                 


Ile Arg His Tyr Arg Ile His Cys Leu Asp Asn Gly Trp Leu Tyr Ile 
145                 150                 155                 160 


Ser Pro Arg Leu Thr Phe Pro Ser Leu Gln Ala Leu Val Asp His Tyr 
                165                 170                 175     


Ser Glu Gly Trp Pro Ala Pro Trp Gln Gly Tyr Thr Pro Thr Cys Asp 
            180                 185                 190         


Cys Ala Glu Asp Thr Thr Gln Leu Glu Arg Ala Gly Gln Leu Pro Pro 
        195                 200                 205             


Val Phe 
    210 


<210>  3882
<211>  2928
<212>  DNA
<213>  Homosapiens

<400>  3882
gctgctgcac tgacggcggg tgcccgcgcc tcagagttac tgatttattc ttgagattcc     60

tctactctcg ttatctgacc tcatggatga acttcaggat gttcagctca cagagatcaa    120

accacttcta aatgataagg aacatgatat agaaacaact catggtgtgg tccacgtcac    180

tataagaggc ttacccaaag gaaacagacc agttatacta acatatcatg acattggcct    240

caaccataaa tcctgtttca atgcattctt taactttgag gatatgcaag agatcaccca    300

gcactttgct gtctgtcatg tggatgcccc aggccagcag gaaggtgcac cctctttccc    360

aacagggtat cagtacccca caatggatga gctggctgaa atgctgcctc ctgttcttac    420

ccacctaagc ctgaaaagca tcattggaat tggagttgga gctggagctt acatcctcag    480

cagatttgca ctcaaccatc cagagcttgt ggaaggcctt gtgctcatta atgttgaccc    540

ttgcgctaaa ggctggattg actgggcagc ttccaaactc tctggcctga caaccaatgt    600

tgtggacatt attttggctc atcactttgg gcaggaagag ttacaggcca acctggacct    660

gatccaaacc tacagaatgc atattgccca agacatcaac caagacaacc tgcagctctt    720

cttgaattcc tacaatggac gcagagacct ggagatcgaa agacccatac tgggccaaaa    780

tgataacaaa tcaaaaacat taaagtgttc tactttactg gtggtagggg acaattcgcc    840

tgcagttgag gctgtggtcg aatgcaattc ccgcctgaac cctataaata caactttgct    900

aaagatggcg gactgtgggg gactgcccca ggtagttcag cctgggaagc tcaccgaggc    960

cttcaagtac tttttgcagg gaatgggcta cataccatct gccagcatga ctcggctcgc   1020

ccgatcacga acccactcaa cctcgagtag cctcggctct ggagaaagtc ccttcagccg   1080

gtctgtcacc agcaatcagt cagatggaac tcaagaatcc tgtgagtccc ctgatgtcct   1140

ggacagacac cagaccatgg aggtgtcctg ctaagcagat gctcctcccc tggaccattg   1200

caagtccatc cttcaaatga ccactccata atataacatt tcatccagta aactggcctc   1260

tactatcttt aactcatgca tggccactga acctctctct agtagcctgg atttatcatt   1320

ctctctgcct gcccaccccc ttttttgtat agcccaagaa ccacttccat gccatactgt   1380

aacattccaa catctttagc tgatcagatc tctccatatc ctctcttgcc agctttttcc   1440

cgtgctcccc caactatgta tcagataaga ttctttgatc ccgactctgt gtgtgcgagc   1500

acgcgtgtct gtgtttgtgt gtgcatagtt ctgtggtttt agacacgctt tcttgtagtg   1560

cttctgcaaa aaacaaaaaa gggacttatt ttgcattctc aatggtgttt ttaagggaat   1620

taggcagaac agatttctag gttgggtagg ccactgcatt ctcttttgtt tgcaaattgg   1680

tcaacaaaat ttgcaaagtg atttcaggag agagcagctt tgaggaatgt ggaaaatcat   1740

aattgccgtc tggaccattg attgattgtg accagtagca gaagggtgcc tgttacatag   1800

agaggctcct tctgtccaaa tgaatttctg tatactcttc tataaataaa agggaggaat   1860

atattctgct ggaagcccat gaaccatcgc tgaggttctg atacaacata gagttttttc   1920

caaggagtga atgtggttta attactggac tctcttagca caggaaggtg gaaacaaaat   1980

gccaggcctc tgctctgaag agcaaaactg ctgtcgctgc agtatctgat accagacatc   2040

cacatatcca caagaagtgc ctcttaggtc tgtgacagag agtgtgtctc cattcctcag   2100

ttcccagaaa ggggagaggt ttggcctaaa aagcatgtag atgggggaga aatgggtggg   2160

gggagaggaa cagccattaa cacagtatca tgtttaacaa gtatagcctt gatttcagta   2220

gatgtaatgg aagccaaatt aaattgatac agaacccatt tctcagagtc tttttttttt   2280

tttgagacag agtctcgctg ttacccaggc tggagtgcaa tggcgcaaac ttggctcact   2340

gcaacctctg ccccctgggt tcaagcgatt ctcctgcctc agcctcccga gtagctgaga   2400

ctacaggcac ctgccaccat acccagctaa gttatgtatt tttagtagag atggagtttc   2460

accatgttgg ccaggctggt ctcaaactcc tgacctcagg tgatccacct gcctcagcct   2520

cccaaagtgc tgggattaca ggcatgagtc attgctccca gccattagaa agattgttaa   2580

tcctatgaac tcccttttgt aggagagaaa gggccaatct gtaggggtag ccctgtccag   2640

gtaaagttgt tttcagcctc atgtctactg ttaggtgagg gagtcacagc cagacagaga   2700

gtattgctgg agggtgagag aattgtggag accaactacc acatagcaag agcccagctc   2760

ttgggagcat tgagatgtaa gctcagggtt acacagttcc aaatcttggg aaggggcttt   2820

tcagacagac tgtttgcttt ctgctgagat aaggaatgca tcactctgcc agagtatgac   2880

tttttacaga ttattaaata aagctgcata tgtctcattg ttacctga                2928


<210>  3883
<211>  363
<212>  PRT
<213>  Homosapiens

<400>  3883

Met Asp Glu Leu Gln Asp Val Gln Leu Thr Glu Ile Lys Pro Leu Leu 
1               5                   10                  15      


Asn Asp Lys Glu His Asp Ile Glu Thr Thr His Gly Val Val His Val 
            20                  25                  30          


Thr Ile Arg Gly Leu Pro Lys Gly Asn Arg Pro Val Ile Leu Thr Tyr 
        35                  40                  45              


His Asp Ile Gly Leu Asn His Lys Ser Cys Phe Asn Ala Phe Phe Asn 
    50                  55                  60                  


Phe Glu Asp Met Gln Glu Ile Thr Gln His Phe Ala Val Cys His Val 
65                  70                  75                  80  


Asp Ala Pro Gly Gln Gln Glu Gly Ala Pro Ser Phe Pro Thr Gly Tyr 
                85                  90                  95      


Gln Tyr Pro Thr Met Asp Glu Leu Ala Glu Met Leu Pro Pro Val Leu 
            100                 105                 110         


Thr His Leu Ser Leu Lys Ser Ile Ile Gly Ile Gly Val Gly Ala Gly 
        115                 120                 125             


Ala Tyr Ile Leu Ser Arg Phe Ala Leu Asn His Pro Glu Leu Val Glu 
    130                 135                 140                 


Gly Leu Val Leu Ile Asn Val Asp Pro Cys Ala Lys Gly Trp Ile Asp 
145                 150                 155                 160 


Trp Ala Ala Ser Lys Leu Ser Gly Leu Thr Thr Asn Val Val Asp Ile 
                165                 170                 175     


Ile Leu Ala His His Phe Gly Gln Glu Glu Leu Gln Ala Asn Leu Asp 
            180                 185                 190         


Leu Ile Gln Thr Tyr Arg Met His Ile Ala Gln Asp Ile Asn Gln Asp 
        195                 200                 205             


Asn Leu Gln Leu Phe Leu Asn Ser Tyr Asn Gly Arg Arg Asp Leu Glu 
    210                 215                 220                 


Ile Glu Arg Pro Ile Leu Gly Gln Asn Asp Asn Lys Ser Lys Thr Leu 
225                 230                 235                 240 


Lys Cys Ser Thr Leu Leu Val Val Gly Asp Asn Ser Pro Ala Val Glu 
                245                 250                 255     


Ala Val Val Glu Cys Asn Ser Arg Leu Asn Pro Ile Asn Thr Thr Leu 
            260                 265                 270         


Leu Lys Met Ala Asp Cys Gly Gly Leu Pro Gln Val Val Gln Pro Gly 
        275                 280                 285             


Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr Ile 
    290                 295                 300                 


Pro Ser Ala Ser Met Thr Arg Leu Ala Arg Ser Arg Thr His Ser Thr 
305                 310                 315                 320 


Ser Ser Ser Leu Gly Ser Gly Glu Ser Pro Phe Ser Arg Ser Val Thr 
                325                 330                 335     


Ser Asn Gln Ser Asp Gly Thr Gln Glu Ser Cys Glu Ser Pro Asp Val 
            340                 345                 350         


Leu Asp Arg His Gln Thr Met Glu Val Ser Cys 
        355                 360             


<210>  3884
<211>  2964
<212>  DNA
<213>  Homosapiens

<400>  3884
gctgctgcac tgacggcggg tgcccgcgcc tcagagttac tgatttattc ttgagattcc     60

tctactctcg ttatctgacc tcatggatga acttcaggat gttcagctca cagagatcaa    120

accacttcta aatgataaga atggtacaag aaacttccag gactttgact gtcaggaaca    180

tgatatagaa acaactcatg gtgtggtcca cgtcactata agaggcttac ccaaaggaaa    240

cagaccagtt atactaacat atcatgacat tggcctcaac cataaatcct gtttcaatgc    300

attctttaac tttgaggata tgcaagagat cacccagcac tttgctgtct gtcatgtgga    360

tgccccaggc cagcaggaag gtgcaccctc tttcccaaca gggtatcagt accccacaat    420

ggatgagctg gctgaaatgc tgcctcctgt tcttacccac ctaagcctga aaagcatcat    480

tggaattgga gttggagctg gagcttacat cctcagcaga tttgcactca accatccaga    540

gcttgtggaa ggccttgtgc tcattaatgt tgacccttgc gctaaaggct ggattgactg    600

ggcagcttcc aaactctctg gcctgacaac caatgttgtg gacattattt tggctcatca    660

ctttgggcag gaagagttac aggccaacct ggacctgatc caaacctaca gaatgcatat    720

tgcccaagac atcaaccaag acaacctgca gctcttcttg aattcctaca atggacgcag    780

agacctggag atcgaaagac ccatactggg ccaaaatgat aacaaatcaa aaacattaaa    840

gtgttctact ttactggtgg taggggacaa ttcgcctgca gttgaggctg tggtcgaatg    900

caattcccgc ctgaacccta taaatacaac tttgctaaag atggcggact gtgggggact    960

gccccaggta gttcagcctg ggaagctcac cgaggccttc aagtactttt tgcagggaat   1020

gggctacata ccatctgcca gcatgactcg gctcgcccga tcacgaaccc actcaacctc   1080

gagtagcctc ggctctggag aaagtccctt cagccggtct gtcaccagca atcagtcaga   1140

tggaactcaa gaatcctgtg agtcccctga tgtcctggac agacaccaga ccatggaggt   1200

gtcctgctaa gcagatgctc ctcccctgga ccattgcaag tccatccttc aaatgaccac   1260

tccataatat aacatttcat ccagtaaact ggcctctact atctttaact catgcatggc   1320

cactgaacct ctctctagta gcctggattt atcattctct ctgcctgccc accccctttt   1380

ttgtatagcc caagaaccac ttccatgcca tactgtaaca ttccaacatc tttagctgat   1440

cagatctctc catatcctct cttgccagct ttttcccgtg ctcccccaac tatgtatcag   1500

ataagattct ttgatcccga ctctgtgtgt gcgagcacgc gtgtctgtgt ttgtgtgtgc   1560

atagttctgt ggttttagac acgctttctt gtagtgcttc tgcaaaaaac aaaaaaggga   1620

cttattttgc attctcaatg gtgtttttaa gggaattagg cagaacagat ttctaggttg   1680

ggtaggccac tgcattctct tttgtttgca aattggtcaa caaaatttgc aaagtgattt   1740

caggagagag cagctttgag gaatgtggaa aatcataatt gccgtctgga ccattgattg   1800

attgtgacca gtagcagaag ggtgcctgtt acatagagag gctccttctg tccaaatgaa   1860

tttctgtata ctcttctata aataaaaggg aggaatatat tctgctggaa gcccatgaac   1920

catcgctgag gttctgatac aacatagagt tttttccaag gagtgaatgt ggtttaatta   1980

ctggactctc ttagcacagg aaggtggaaa caaaatgcca ggcctctgct ctgaagagca   2040

aaactgctgt cgctgcagta tctgatacca gacatccaca tatccacaag aagtgcctct   2100

taggtctgtg acagagagtg tgtctccatt cctcagttcc cagaaagggg agaggtttgg   2160

cctaaaaagc atgtagatgg gggagaaatg ggtgggggga gaggaacagc cattaacaca   2220

gtatcatgtt taacaagtat agccttgatt tcagtagatg taatggaagc caaattaaat   2280

tgatacagaa cccatttctc agagtctttt tttttttttg agacagagtc tcgctgttac   2340

ccaggctgga gtgcaatggc gcaaacttgg ctcactgcaa cctctgcccc ctgggttcaa   2400

gcgattctcc tgcctcagcc tcccgagtag ctgagactac aggcacctgc caccataccc   2460

agctaagtta tgtattttta gtagagatgg agtttcacca tgttggccag gctggtctca   2520

aactcctgac ctcaggtgat ccacctgcct cagcctccca aagtgctggg attacaggca   2580

tgagtcattg ctcccagcca ttagaaagat tgttaatcct atgaactccc ttttgtagga   2640

gagaaagggc caatctgtag gggtagccct gtccaggtaa agttgttttc agcctcatgt   2700

ctactgttag gtgagggagt cacagccaga cagagagtat tgctggaggg tgagagaatt   2760

gtggagacca actaccacat agcaagagcc cagctcttgg gagcattgag atgtaagctc   2820

agggttacac agttccaaat cttgggaagg ggcttttcag acagactgtt tgctttctgc   2880

tgagataagg aatgcatcac tctgccagag tatgactttt tacagattat taaataaagc   2940

tgcatatgtc tcattgttac ctga                                          2964


<210>  3885
<211>  375
<212>  PRT
<213>  Homosapiens

<400>  3885

Met Asp Glu Leu Gln Asp Val Gln Leu Thr Glu Ile Lys Pro Leu Leu 
1               5                   10                  15      


Asn Asp Lys Asn Gly Thr Arg Asn Phe Gln Asp Phe Asp Cys Gln Glu 
            20                  25                  30          


His Asp Ile Glu Thr Thr His Gly Val Val His Val Thr Ile Arg Gly 
        35                  40                  45              


Leu Pro Lys Gly Asn Arg Pro Val Ile Leu Thr Tyr His Asp Ile Gly 
    50                  55                  60                  


Leu Asn His Lys Ser Cys Phe Asn Ala Phe Phe Asn Phe Glu Asp Met 
65                  70                  75                  80  


Gln Glu Ile Thr Gln His Phe Ala Val Cys His Val Asp Ala Pro Gly 
                85                  90                  95      


Gln Gln Glu Gly Ala Pro Ser Phe Pro Thr Gly Tyr Gln Tyr Pro Thr 
            100                 105                 110         


Met Asp Glu Leu Ala Glu Met Leu Pro Pro Val Leu Thr His Leu Ser 
        115                 120                 125             


Leu Lys Ser Ile Ile Gly Ile Gly Val Gly Ala Gly Ala Tyr Ile Leu 
    130                 135                 140                 


Ser Arg Phe Ala Leu Asn His Pro Glu Leu Val Glu Gly Leu Val Leu 
145                 150                 155                 160 


Ile Asn Val Asp Pro Cys Ala Lys Gly Trp Ile Asp Trp Ala Ala Ser 
                165                 170                 175     


Lys Leu Ser Gly Leu Thr Thr Asn Val Val Asp Ile Ile Leu Ala His 
            180                 185                 190         


His Phe Gly Gln Glu Glu Leu Gln Ala Asn Leu Asp Leu Ile Gln Thr 
        195                 200                 205             


Tyr Arg Met His Ile Ala Gln Asp Ile Asn Gln Asp Asn Leu Gln Leu 
    210                 215                 220                 


Phe Leu Asn Ser Tyr Asn Gly Arg Arg Asp Leu Glu Ile Glu Arg Pro 
225                 230                 235                 240 


Ile Leu Gly Gln Asn Asp Asn Lys Ser Lys Thr Leu Lys Cys Ser Thr 
                245                 250                 255     


Leu Leu Val Val Gly Asp Asn Ser Pro Ala Val Glu Ala Val Val Glu 
            260                 265                 270         


Cys Asn Ser Arg Leu Asn Pro Ile Asn Thr Thr Leu Leu Lys Met Ala 
        275                 280                 285             


Asp Cys Gly Gly Leu Pro Gln Val Val Gln Pro Gly Lys Leu Thr Glu 
    290                 295                 300                 


Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr Ile Pro Ser Ala Ser 
305                 310                 315                 320 


Met Thr Arg Leu Ala Arg Ser Arg Thr His Ser Thr Ser Ser Ser Leu 
                325                 330                 335     


Gly Ser Gly Glu Ser Pro Phe Ser Arg Ser Val Thr Ser Asn Gln Ser 
            340                 345                 350         


Asp Gly Thr Gln Glu Ser Cys Glu Ser Pro Asp Val Leu Asp Arg His 
        355                 360                 365             


Gln Thr Met Glu Val Ser Cys 
    370                 375 


<210>  3886
<211>  2095
<212>  DNA
<213>  Homosapiens

<400>  3886
gatcagggag tatcggctgc gggtgcgcaa ggcgtccagg agtgacctgg ggctgtggag     60

agcgacccgt ggccttgtgt ttcaggtacg gaggttccgg actggacggg cgtcaggaag    120

tcacagactt gtcctctgat gtggccccgc ccgccgccgc actaatctct tcggcgtcgt    180

acccgtcggc ccagctcgac ccgccgcagc cccggccccg accgtggaca ctgggggtcc    240

ccgagggcgc tgcgacctcc tcccggagtt taccacctag gatgacttca gtgactagat    300

cagagatcat agatgaaaaa ggaccagtga tgtctaagac tcatgatcat caattggaat    360

caagtctcag tcctgtggaa gtgtttgcta aaacatctgc ctccctggag atgaatcaag    420

gcgtttcaga ggaaagaatt caccttggct ctagccctaa aaaaggggga aattgtgatc    480

tcagccacca ggaaagactt cagtcgaagt cccttcattt gtctcctcaa gaacaatctg    540

ccagttatca agacaggagg caatcctggc ggcgagcaag tatgaaagaa acgaaccggc    600

ggaagtcgct gcatcccatt caccagggca tcacagagct cagccggtct atcagtgtcg    660

atttagcaga aagcaaacgg cttggctgtc tcctgctttc cagttcccag ttctctattc    720

agaaacttga acctttccta agggacacta agggcttcag tcttgaaagt tttagagcca    780

aagcatcttc tctttctgaa gaattgaaac attttgcaga cggactggaa actgatggaa    840

ctctacaaaa atgttttgaa gattcaaatg gaaaagcatc agatttttct ttggaagcat    900

ctgtggctga gatgaaggaa tacataacaa agttttcttt agaacgtcag acttgggatc    960

agctcttgct tcactaccag caggaggcta aagagatatt gtccagagga tcaactgagg   1020

ccaaaattac tgaggtcaaa gtggaaccta tgacatatct tgggtcttct cagaatgaag   1080

ttcttaatac aaaacctgac taccagaaaa tattacagaa ccagagcaaa gtctttgact   1140

gtatggagtt ggtgatggat gaactgcaag gatcagtgaa acagctgcag gcctttatgg   1200

atgaaagtac ccagtgcttc cagaaggtgt cagtacagct cggaaagaga agcatgcaac   1260

aattagatcc ctcaccagct cgaaaactgt tgaagcttca gctacagaac ccacctgcca   1320

tacatggatc tggatctgga tcttgtcagt gactttatga gagtttctgc cacaaggtgc   1380

ccaagaggag aggaatggga agagtgcccc agcacgtggt gactgcgtga tttctgctcg   1440

ttgcctttga agataactgg caggactgac tgtagaacac tttgactttt ttcaaaaagt   1500

gatggaattt gtacatccaa atgaatattg tatagacaat tttcccagga atgtgcaaaa   1560

tgcttgaaag ttcaaacttc ttttttgaaa tgatcttcag atccagtggc ccattctttt   1620

atctttatcc tgtgaaggtg tttttcaggt tttgaaacaa tccaaaaatc atttaggacc   1680

aagtctaagg aaacatttta gtggccaagt tggattccga ttgtaaagga atgatactaa   1740

ttttctagca tggctctgaa ggtgatttta ggtagaagag ttttgaggct gggcgcaatg   1800

gctcacgcct gtaatcctag cattttgggt gactgaggcg ggtggattgc ttgagcccag   1860

aagttgaaga ccagcctgag aaataaggtg aaaccctgtc tacaaaaaat acaaaaagtt   1920

agctgggtgt ggtggcgtgt gcctgtagtg ctagctactc agaaggctga ggtgggagga   1980

ttgtttgagc ccaggaggtt gaggctgcag tgagttctaa ttgcgccact gcactccagc   2040

ctgagcgaca gagtgagaca ctgtcttaaa aaaaattaaa aattgtaaga aaatg        2095


<210>  3887
<211>  356
<212>  PRT
<213>  Homosapiens

<400>  3887

Met Thr Ser Val Thr Arg Ser Glu Ile Ile Asp Glu Lys Gly Pro Val 
1               5                   10                  15      


Met Ser Lys Thr His Asp His Gln Leu Glu Ser Ser Leu Ser Pro Val 
            20                  25                  30          


Glu Val Phe Ala Lys Thr Ser Ala Ser Leu Glu Met Asn Gln Gly Val 
        35                  40                  45              


Ser Glu Glu Arg Ile His Leu Gly Ser Ser Pro Lys Lys Gly Gly Asn 
    50                  55                  60                  


Cys Asp Leu Ser His Gln Glu Arg Leu Gln Ser Lys Ser Leu His Leu 
65                  70                  75                  80  


Ser Pro Gln Glu Gln Ser Ala Ser Tyr Gln Asp Arg Arg Gln Ser Trp 
                85                  90                  95      


Arg Arg Ala Ser Met Lys Glu Thr Asn Arg Arg Lys Ser Leu His Pro 
            100                 105                 110         


Ile His Gln Gly Ile Thr Glu Leu Ser Arg Ser Ile Ser Val Asp Leu 
        115                 120                 125             


Ala Glu Ser Lys Arg Leu Gly Cys Leu Leu Leu Ser Ser Ser Gln Phe 
    130                 135                 140                 


Ser Ile Gln Lys Leu Glu Pro Phe Leu Arg Asp Thr Lys Gly Phe Ser 
145                 150                 155                 160 


Leu Glu Ser Phe Arg Ala Lys Ala Ser Ser Leu Ser Glu Glu Leu Lys 
                165                 170                 175     


His Phe Ala Asp Gly Leu Glu Thr Asp Gly Thr Leu Gln Lys Cys Phe 
            180                 185                 190         


Glu Asp Ser Asn Gly Lys Ala Ser Asp Phe Ser Leu Glu Ala Ser Val 
        195                 200                 205             


Ala Glu Met Lys Glu Tyr Ile Thr Lys Phe Ser Leu Glu Arg Gln Thr 
    210                 215                 220                 


Trp Asp Gln Leu Leu Leu His Tyr Gln Gln Glu Ala Lys Glu Ile Leu 
225                 230                 235                 240 


Ser Arg Gly Ser Thr Glu Ala Lys Ile Thr Glu Val Lys Val Glu Pro 
                245                 250                 255     


Met Thr Tyr Leu Gly Ser Ser Gln Asn Glu Val Leu Asn Thr Lys Pro 
            260                 265                 270         


Asp Tyr Gln Lys Ile Leu Gln Asn Gln Ser Lys Val Phe Asp Cys Met 
        275                 280                 285             


Glu Leu Val Met Asp Glu Leu Gln Gly Ser Val Lys Gln Leu Gln Ala 
    290                 295                 300                 


Phe Met Asp Glu Ser Thr Gln Cys Phe Gln Lys Val Ser Val Gln Leu 
305                 310                 315                 320 


Gly Lys Arg Ser Met Gln Gln Leu Asp Pro Ser Pro Ala Arg Lys Leu 
                325                 330                 335     


Leu Lys Leu Gln Leu Gln Asn Pro Pro Ala Ile His Gly Ser Gly Ser 
            340                 345                 350         


Gly Ser Cys Gln 
        355     


<210>  3888
<211>  2701
<212>  DNA
<213>  Homosapiens

<400>  3888
gagcctgcgc aggaggccaa taggctgcca atactccttg gactccccgc cagggccctg     60

ctgtcagtgc gcctgcgcgc gggtccggcg ccgaggttct tgactgctgt gccggacgcc    120

aggtgtagcc atgcagcgag ccgattccga gcagccctcc aagcgtcccc gttgcgatga    180

cagcccgaga accccctcaa acaccccttc cgcagaggca gactggtccc cgggcctgga    240

actccatccc gactacaaga catggggtcc ggagcaggtg tgctccttcc tcaggcgcgg    300

tggctttgaa gagccggtgc tgctgaagaa catccgagaa aatgaaatca caggcgcatt    360

actgccttgt cttgatgagt ctcgttttga aaatcttgga gtaagttcct tgggggagag    420

gaagaagctg cttagttata tccagcgatt ggttcaaatc cacgttgata caatgaaggt    480

aattaatgat cctatccatg gccacattga gctccaccct ctcctcgtcc gaatcattga    540

tacacctcaa tttcaacgtc ttcgatacat caaacagctg ggaggtggtt actatgtttt    600

tccaggagct tcacacaatc gatttgagca tagtctaggg gtggggtatc tagcaggatg    660

tctagttcac gcactgggtg aaaaacaacc agagctgcag ataagtgaac gagatgttct    720

ctgtgttcag attgctggac tttgtcatga tctcggtcat gggccatttt ctcacatgtt    780

tgatggacga tttattccac ttgctcgccc ggaggtgaaa tggacgcatg aacaaggctc    840

agttatgatg tttgagcacc ttattaattc taatggaatt aagcctgtca tggaacaata    900

tggtctcatc cctgaagaag atatttgctt tataaaggaa caaattgtag gaccacttga    960

atcacctgtc gaagattcat tgtggccata taaagggcgt cctgaaaaca aaagcttcct   1020

ttatgagata gtatctaata aaagaaatgg cattgatgtg gacaaatggg attattttgc   1080

cagggactgc catcatcttg gaatccaaaa taattttgat tacaagcgct ttattaagtt   1140

tgcccgtgtc tgtgaagtag acaatgagtt gcgtatttgt gctagagata aggaagttgg   1200

aaatctgtat gacatgttcc acactcgcaa ctctttacac cgtagagctt atcaacacaa   1260

agttggcaac attattgata caatgattac agatgctttc ctcaaagcag atgactacat   1320

agagattaca ggtgctggag gaaaaaagta tcgcatttct acagcaattg acgacatgga   1380

agcctatact aagctgacag ataacatttt tctggagatt ttatactcta ctgatcccaa   1440

attgaaagac gcacgagaga ttttaaaaca aattgaatac cgtaatctat tcaagtatgt   1500

gggtgagacg cagccaacag gacaaataaa gattaaaagg gaggactatg aatctcttcc   1560

aaaagaggtt gccagtgcta aacccaaagt attgctagac gtgaaactga aggctgaaga   1620

ttttatagtg gatgttatca acatggatta tggaatgcaa gaaaagaatc caattgatca   1680

tgttagcttc tattgtaaga ctgcccccaa cagagcaatc aggattacta aaaaccaggt   1740

ttcacaactt ctgccagaga aatttgcaga gcagctgatt cgagtatatt gtaagaaggt   1800

ggacagaaag agtttgtatg ccgcaagaca atattttgtt cagtggtgtg cagacagaaa   1860

tttcaccaag ccgcaggatg gcgatgttat agccccactc ataacacctc aaaaaaagga   1920

atggaacgac agtacttcag tccaaaatcc aactcgcctc cgagaagcat ccaaaagcag   1980

agtccagctt tttaaagatg acccaatgtg aatgtctgta gtcagttgtt tacaaactcc   2040

ctctcctgca caattcattt agaggcttca atcatagaat tctgcaaatt aatgacaact   2100

catgctttaa ttttgtattt tgaatgtaca cgcatgctga agctaagtaa cttttaatca   2160

aagaaataag atggtattag gcaaatctta ctatactatg aaaagcatta ccttgcctat   2220

ttttaatatt attaaagcct ttctccttca gtagtctatt ttcttagaat aacaactctt   2280

ttatctattc tgaactctat tttttttctt ttttaagaga caaggttttg ctctgttgcc   2340

cagcttggac tcgaactttc ctgggctcaa gcgaccctcc tgcctcagcc ccccaagtag   2400

ctgggactaa agtcatgtgc caccacaccc agcttactct gaacttttat gacagatgat   2460

tgttttttgt ttttaatgta gaaatgagac aagggtacaa attggaacta gaaattgaca   2520

ttgtcattga caaacatggc taaaaacaaa acatcaaatc ctgcccccgt gaagagttcc   2580

ctgtcacctc aagtttgagg atagtcctct aagagtgacc taagcataag tgaaagacac   2640

ctcccctcac ccttctagcc ccctacaagg tgccaggttg gggtaaagag ttggagatga   2700

t                                                                   2701


<210>  3889
<211>  626
<212>  PRT
<213>  Homosapiens

<400>  3889

Met Gln Arg Ala Asp Ser Glu Gln Pro Ser Lys Arg Pro Arg Cys Asp 
1               5                   10                  15      


Asp Ser Pro Arg Thr Pro Ser Asn Thr Pro Ser Ala Glu Ala Asp Trp 
            20                  25                  30          


Ser Pro Gly Leu Glu Leu His Pro Asp Tyr Lys Thr Trp Gly Pro Glu 
        35                  40                  45              


Gln Val Cys Ser Phe Leu Arg Arg Gly Gly Phe Glu Glu Pro Val Leu 
    50                  55                  60                  


Leu Lys Asn Ile Arg Glu Asn Glu Ile Thr Gly Ala Leu Leu Pro Cys 
65                  70                  75                  80  


Leu Asp Glu Ser Arg Phe Glu Asn Leu Gly Val Ser Ser Leu Gly Glu 
                85                  90                  95      


Arg Lys Lys Leu Leu Ser Tyr Ile Gln Arg Leu Val Gln Ile His Val 
            100                 105                 110         


Asp Thr Met Lys Val Ile Asn Asp Pro Ile His Gly His Ile Glu Leu 
        115                 120                 125             


His Pro Leu Leu Val Arg Ile Ile Asp Thr Pro Gln Phe Gln Arg Leu 
    130                 135                 140                 


Arg Tyr Ile Lys Gln Leu Gly Gly Gly Tyr Tyr Val Phe Pro Gly Ala 
145                 150                 155                 160 


Ser His Asn Arg Phe Glu His Ser Leu Gly Val Gly Tyr Leu Ala Gly 
                165                 170                 175     


Cys Leu Val His Ala Leu Gly Glu Lys Gln Pro Glu Leu Gln Ile Ser 
            180                 185                 190         


Glu Arg Asp Val Leu Cys Val Gln Ile Ala Gly Leu Cys His Asp Leu 
        195                 200                 205             


Gly His Gly Pro Phe Ser His Met Phe Asp Gly Arg Phe Ile Pro Leu 
    210                 215                 220                 


Ala Arg Pro Glu Val Lys Trp Thr His Glu Gln Gly Ser Val Met Met 
225                 230                 235                 240 


Phe Glu His Leu Ile Asn Ser Asn Gly Ile Lys Pro Val Met Glu Gln 
                245                 250                 255     


Tyr Gly Leu Ile Pro Glu Glu Asp Ile Cys Phe Ile Lys Glu Gln Ile 
            260                 265                 270         


Val Gly Pro Leu Glu Ser Pro Val Glu Asp Ser Leu Trp Pro Tyr Lys 
        275                 280                 285             


Gly Arg Pro Glu Asn Lys Ser Phe Leu Tyr Glu Ile Val Ser Asn Lys 
    290                 295                 300                 


Arg Asn Gly Ile Asp Val Asp Lys Trp Asp Tyr Phe Ala Arg Asp Cys 
305                 310                 315                 320 


His His Leu Gly Ile Gln Asn Asn Phe Asp Tyr Lys Arg Phe Ile Lys 
                325                 330                 335     


Phe Ala Arg Val Cys Glu Val Asp Asn Glu Leu Arg Ile Cys Ala Arg 
            340                 345                 350         


Asp Lys Glu Val Gly Asn Leu Tyr Asp Met Phe His Thr Arg Asn Ser 
        355                 360                 365             


Leu His Arg Arg Ala Tyr Gln His Lys Val Gly Asn Ile Ile Asp Thr 
    370                 375                 380                 


Met Ile Thr Asp Ala Phe Leu Lys Ala Asp Asp Tyr Ile Glu Ile Thr 
385                 390                 395                 400 


Gly Ala Gly Gly Lys Lys Tyr Arg Ile Ser Thr Ala Ile Asp Asp Met 
                405                 410                 415     


Glu Ala Tyr Thr Lys Leu Thr Asp Asn Ile Phe Leu Glu Ile Leu Tyr 
            420                 425                 430         


Ser Thr Asp Pro Lys Leu Lys Asp Ala Arg Glu Ile Leu Lys Gln Ile 
        435                 440                 445             


Glu Tyr Arg Asn Leu Phe Lys Tyr Val Gly Glu Thr Gln Pro Thr Gly 
    450                 455                 460                 


Gln Ile Lys Ile Lys Arg Glu Asp Tyr Glu Ser Leu Pro Lys Glu Val 
465                 470                 475                 480 


Ala Ser Ala Lys Pro Lys Val Leu Leu Asp Val Lys Leu Lys Ala Glu 
                485                 490                 495     


Asp Phe Ile Val Asp Val Ile Asn Met Asp Tyr Gly Met Gln Glu Lys 
            500                 505                 510         


Asn Pro Ile Asp His Val Ser Phe Tyr Cys Lys Thr Ala Pro Asn Arg 
        515                 520                 525             


Ala Ile Arg Ile Thr Lys Asn Gln Val Ser Gln Leu Leu Pro Glu Lys 
    530                 535                 540                 


Phe Ala Glu Gln Leu Ile Arg Val Tyr Cys Lys Lys Val Asp Arg Lys 
545                 550                 555                 560 


Ser Leu Tyr Ala Ala Arg Gln Tyr Phe Val Gln Trp Cys Ala Asp Arg 
                565                 570                 575     


Asn Phe Thr Lys Pro Gln Asp Gly Asp Val Ile Ala Pro Leu Ile Thr 
            580                 585                 590         


Pro Gln Lys Lys Glu Trp Asn Asp Ser Thr Ser Val Gln Asn Pro Thr 
        595                 600                 605             


Arg Leu Arg Glu Ala Ser Lys Ser Arg Val Gln Leu Phe Lys Asp Asp 
    610                 615                 620                 


Pro Met 
625     


<210>  3890
<211>  4270
<212>  DNA
<213>  Homosapiens

<400>  3890
gcaggtggtt gtgggtagcg cgcctgggag ggagaaagaa gtcgggggcc gtggcgcgca     60

gcccgcgggg cctgaaggga tgttcgagga caagccccac gctgaggggg cggcggtggt    120

cgccgcagcc ggggaggcgc tacaggccct gtgccaggag ctgaacctgg acgaggggag    180

cgcggccgaa gccctggacg actttactgc catccgaggc aactacagcc tagagggaga    240

agttacacac tggttggcat gttcattata tgttgcatgc cgcaaaagca ttattcccac    300

ggttggaaag ggtatcatgg aaggcaactg tgtttcactt accagaatac tacgttcagc    360

taaattaagt ttaatacaat tttttagtaa aatgaagaaa tggatggaca tgtcaaatct    420

accacaagaa tttcgtgaac gtatagaaag gctagagaga aattttgagg tgtctactgt    480

aatattcaaa aaatatgagc caattttttt agatatattt caaaatccat atgaagaacc    540

accaaagtta ccacgaagcc ggaagcagag gaggattcct tgcagtgtta aggatctgtt    600

taatttctgt tggacacttt ttgtttatac taagggtaat tttcggatga ttggggatga    660

cttagtaaac tcttatcatt tacttctatg ctgcttggat ctgatttttg ccaatgcgat    720

tatgtgccca aatagacaag acttgctaaa tccatcattt aaaggtttac catctgattt    780

tcatactgct gactttacgg cttctgaaga gccaccctgc atcattgctg tactgtgtga    840

actgcatgat ggacttctcg tagaagcaaa aggaataaag gagcactact ttaagccata    900

tatttcaaaa ctctttgaca ggaagatatt aaaaggagaa tgcctcctgg acctttcaag    960

ttttactgat aatagcaaag cagtgaataa ggagtatgaa gagtatgttc taactgttgg   1020

tgattttgat gagaggatct ttttgggagc agacgcagaa gaggaaattg gaacacctcg   1080

aaagttcact cgtgacaccc cattagggaa actgacagca caggctaatg tggagtataa   1140

ccttcaacag cactttgaaa aaaaaaggtc atttgcacct tctaccccac tgaccggacg   1200

gagatattta cgagaaaaag aagcagtcat tactcctgtt gcatcagcca cccaaagtgt   1260

gagccggtta cagagtattg tggctggtct gaaaaatgca ccaagtgacc aacttataaa   1320

tatttttgaa tcttgtgtgc gtaatcctgt ggaaaacatt atgaaaatac taaaaggaat   1380

aggagagact ttctgtcaac actatactca atcaacagat gaacagccag gatctcacat   1440

agactttgct gtaaacagac taaagctggc agaaattttg tattataaaa tactagagac   1500

tgtaatggtt caggaaacac gaagacttca tggaatggac atgtcagttc ttttagagca   1560

agatatattt catcgttcct tgatggcttg ttgtttggaa attgtgctct ttgcctatag   1620

ctcacctcgt acttttcctt ggattattga agttctcaac ttgcaaccat tttactttta   1680

taaggttatt gaggtggtga tccgctcaga agaggggctc tcaagggaca tggtgaaaca   1740

cctaaacagc attgaagaac agattttgga gagtttagca tggagtcacg attctgcact   1800

gtgggaggct ctccaggttt ctgcaaacaa agttcctacc tgtgaagaag ttatattccc   1860

aaataacttt gaaacaggaa atggaggaaa tgtgcaggga catcttcccc tgatgccaat   1920

gtctcctcta atgcacccaa gagtcaagga agttcgaact gacagtggga gtcttcgaag   1980

agatatgcaa ccattgtctc caatttctgt ccatgaacgc tacagttctc ctaccgcagg   2040

gagtgctaag agaagactct ttggagagga ccccccaaag gaaatgctta tggacaagat   2100

cataacagaa ggaacaaaat tgaaaatcgc tccttcttca agcattactg ctgaaaatgt   2160

atcaatttta cctggtcaaa ctcttctaac aatggccaca gccccagtaa caggaacaac   2220

aggacataaa gttacaattc cattacatgg tgtcgcaaat gatgctggag agatcacact   2280

gatacctctt tccatgaata caaatcagga gtccaaagtc aagagtcctg tatcacttac   2340

tgctcattca ttaattggtg cttctccaaa acagaccaat ctgactaaag cacaagaggt   2400

acattcaact ggaataaaca ggccaaagag aactgggtcc ttagcactat tttacagaaa   2460

ggtctatcat ttggcaagtg tacgcttacg tgatctatgt ctaaaactgg atgtttcaaa   2520

tgagttacga aggaagatat ggacgtgttt tgaattcact ttagttcact gtcctgatct   2580

aatgaaagac aggcatttgg atcagctcct cctttgtgcc ttttatatca tggcaaaggt   2640

aacaaaagaa gaaagaactt ttcaagaaat tatgaaaagt tataggaatc agccccaagc   2700

taatagtcac gtatatagaa gtgttctgct gaaaagtatt ccaagagaag ttgtggcata   2760

taataaaaat ataaatgatg actttgaaat gatagattgt gacttagaag atgctacaaa   2820

aacacctgac tgttccagtg gaccagtgaa agaggaaaga ggtgatctta taaaatttta   2880

caatacaata tatgtaggaa gagtgaagtc atttgcactg aaatacgact tggcgaatca   2940

ggaccatatg atggatgctc caccactctc tccttttcca catattaaac aacagccagg   3000

ctcaccacgc cgcatttccc agcagcactc catttatatt tccccgcaca agaatgggtc   3060

aggccttaca ccaagaagcg ctctgctgta caagttcaat ggcagccctt ctaagagttt   3120

gaaagatatc aacaacatga taaggcaagg tgagcagaga accaagaagc gagtaatagc   3180

catcgatagt gatgcagaat cccctgccaa acgcgtctgt caagaaaatg atgacgtttt   3240

actgaaacga ctacaggatg ttgtcagtga aagagcaaat cattaatgtt gttcttgttt   3300

ctatgataaa agcactttca gattgttctg cagaaagttg gagctctgtc cttcaaacct   3360

tttagcccta tagatgataa atatcactgg gttataagaa aaaattgcac aaaaattatg   3420

tgctttttaa aatatttatc caaaatgtag ttgacagaga tgtattttga gttggattgg   3480

aaaggaatat tttaagtgcc ttttaaaaat actaatagtc cggccaggcg ctgtggctca   3540

cgcctgtaat cccaggactt tgggaggcca aggcgggcag atcaccggag gtcaggagtt   3600

cgagaccagc ctgaccaaca tggagaaacc ccatctctac taaaaataca aaattagccg   3660

ggtgtggtgg cgcatgcctg taatcccagc tacttgggag gctgaggcag aattgcttga   3720

acccaggaag cggaggttgt ggtgagccaa ggttgcgcca ctgcactcca gcctgggcaa   3780

caagagtaaa actccatctc aaaaaatata tatatatata taaataggga atttttttta   3840

atgtttgctc cttgagtttt caagatgaaa taaggagaaa ccccataact ttttagctct   3900

cttttaaaaa taaatgtctc cttctgtgtt ctgtaatatg aggataaata atctactttt   3960

gatagcatgc tttgagatat ttgtattctt aatttaatat tgaaggaagg ggttggttcc   4020

catagtacct ggccagaggg ttatatacca tcctgtctct ggcccactgt ggtaattcca   4080

catccaggta ccaccgccat tcagagttgt ctcacccctt ctcgtgcctt ttctctcctt   4140

gagctttata aacagatttg tacctgagcc ccagtgctac actcatcctt gctttccagc   4200

cctaagccat ctcagcctga tgtcacaacc caataaatgg ggcactttct tcttttgtaa   4260

actattatca                                                          4270


<210>  3891
<211>  1068
<212>  PRT
<213>  Homosapiens

<400>  3891

Met Phe Glu Asp Lys Pro His Ala Glu Gly Ala Ala Val Val Ala Ala 
1               5                   10                  15      


Ala Gly Glu Ala Leu Gln Ala Leu Cys Gln Glu Leu Asn Leu Asp Glu 
            20                  25                  30          


Gly Ser Ala Ala Glu Ala Leu Asp Asp Phe Thr Ala Ile Arg Gly Asn 
        35                  40                  45              


Tyr Ser Leu Glu Gly Glu Val Thr His Trp Leu Ala Cys Ser Leu Tyr 
    50                  55                  60                  


Val Ala Cys Arg Lys Ser Ile Ile Pro Thr Val Gly Lys Gly Ile Met 
65                  70                  75                  80  


Glu Gly Asn Cys Val Ser Leu Thr Arg Ile Leu Arg Ser Ala Lys Leu 
                85                  90                  95      


Ser Leu Ile Gln Phe Phe Ser Lys Met Lys Lys Trp Met Asp Met Ser 
            100                 105                 110         


Asn Leu Pro Gln Glu Phe Arg Glu Arg Ile Glu Arg Leu Glu Arg Asn 
        115                 120                 125             


Phe Glu Val Ser Thr Val Ile Phe Lys Lys Tyr Glu Pro Ile Phe Leu 
    130                 135                 140                 


Asp Ile Phe Gln Asn Pro Tyr Glu Glu Pro Pro Lys Leu Pro Arg Ser 
145                 150                 155                 160 


Arg Lys Gln Arg Arg Ile Pro Cys Ser Val Lys Asp Leu Phe Asn Phe 
                165                 170                 175     


Cys Trp Thr Leu Phe Val Tyr Thr Lys Gly Asn Phe Arg Met Ile Gly 
            180                 185                 190         


Asp Asp Leu Val Asn Ser Tyr His Leu Leu Leu Cys Cys Leu Asp Leu 
        195                 200                 205             


Ile Phe Ala Asn Ala Ile Met Cys Pro Asn Arg Gln Asp Leu Leu Asn 
    210                 215                 220                 


Pro Ser Phe Lys Gly Leu Pro Ser Asp Phe His Thr Ala Asp Phe Thr 
225                 230                 235                 240 


Ala Ser Glu Glu Pro Pro Cys Ile Ile Ala Val Leu Cys Glu Leu His 
                245                 250                 255     


Asp Gly Leu Leu Val Glu Ala Lys Gly Ile Lys Glu His Tyr Phe Lys 
            260                 265                 270         


Pro Tyr Ile Ser Lys Leu Phe Asp Arg Lys Ile Leu Lys Gly Glu Cys 
        275                 280                 285             


Leu Leu Asp Leu Ser Ser Phe Thr Asp Asn Ser Lys Ala Val Asn Lys 
    290                 295                 300                 


Glu Tyr Glu Glu Tyr Val Leu Thr Val Gly Asp Phe Asp Glu Arg Ile 
305                 310                 315                 320 


Phe Leu Gly Ala Asp Ala Glu Glu Glu Ile Gly Thr Pro Arg Lys Phe 
                325                 330                 335     


Thr Arg Asp Thr Pro Leu Gly Lys Leu Thr Ala Gln Ala Asn Val Glu 
            340                 345                 350         


Tyr Asn Leu Gln Gln His Phe Glu Lys Lys Arg Ser Phe Ala Pro Ser 
        355                 360                 365             


Thr Pro Leu Thr Gly Arg Arg Tyr Leu Arg Glu Lys Glu Ala Val Ile 
    370                 375                 380                 


Thr Pro Val Ala Ser Ala Thr Gln Ser Val Ser Arg Leu Gln Ser Ile 
385                 390                 395                 400 


Val Ala Gly Leu Lys Asn Ala Pro Ser Asp Gln Leu Ile Asn Ile Phe 
                405                 410                 415     


Glu Ser Cys Val Arg Asn Pro Val Glu Asn Ile Met Lys Ile Leu Lys 
            420                 425                 430         


Gly Ile Gly Glu Thr Phe Cys Gln His Tyr Thr Gln Ser Thr Asp Glu 
        435                 440                 445             


Gln Pro Gly Ser His Ile Asp Phe Ala Val Asn Arg Leu Lys Leu Ala 
    450                 455                 460                 


Glu Ile Leu Tyr Tyr Lys Ile Leu Glu Thr Val Met Val Gln Glu Thr 
465                 470                 475                 480 


Arg Arg Leu His Gly Met Asp Met Ser Val Leu Leu Glu Gln Asp Ile 
                485                 490                 495     


Phe His Arg Ser Leu Met Ala Cys Cys Leu Glu Ile Val Leu Phe Ala 
            500                 505                 510         


Tyr Ser Ser Pro Arg Thr Phe Pro Trp Ile Ile Glu Val Leu Asn Leu 
        515                 520                 525             


Gln Pro Phe Tyr Phe Tyr Lys Val Ile Glu Val Val Ile Arg Ser Glu 
    530                 535                 540                 


Glu Gly Leu Ser Arg Asp Met Val Lys His Leu Asn Ser Ile Glu Glu 
545                 550                 555                 560 


Gln Ile Leu Glu Ser Leu Ala Trp Ser His Asp Ser Ala Leu Trp Glu 
                565                 570                 575     


Ala Leu Gln Val Ser Ala Asn Lys Val Pro Thr Cys Glu Glu Val Ile 
            580                 585                 590         


Phe Pro Asn Asn Phe Glu Thr Gly Asn Gly Gly Asn Val Gln Gly His 
        595                 600                 605             


Leu Pro Leu Met Pro Met Ser Pro Leu Met His Pro Arg Val Lys Glu 
    610                 615                 620                 


Val Arg Thr Asp Ser Gly Ser Leu Arg Arg Asp Met Gln Pro Leu Ser 
625                 630                 635                 640 


Pro Ile Ser Val His Glu Arg Tyr Ser Ser Pro Thr Ala Gly Ser Ala 
                645                 650                 655     


Lys Arg Arg Leu Phe Gly Glu Asp Pro Pro Lys Glu Met Leu Met Asp 
            660                 665                 670         


Lys Ile Ile Thr Glu Gly Thr Lys Leu Lys Ile Ala Pro Ser Ser Ser 
        675                 680                 685             


Ile Thr Ala Glu Asn Val Ser Ile Leu Pro Gly Gln Thr Leu Leu Thr 
    690                 695                 700                 


Met Ala Thr Ala Pro Val Thr Gly Thr Thr Gly His Lys Val Thr Ile 
705                 710                 715                 720 


Pro Leu His Gly Val Ala Asn Asp Ala Gly Glu Ile Thr Leu Ile Pro 
                725                 730                 735     


Leu Ser Met Asn Thr Asn Gln Glu Ser Lys Val Lys Ser Pro Val Ser 
            740                 745                 750         


Leu Thr Ala His Ser Leu Ile Gly Ala Ser Pro Lys Gln Thr Asn Leu 
        755                 760                 765             


Thr Lys Ala Gln Glu Val His Ser Thr Gly Ile Asn Arg Pro Lys Arg 
    770                 775                 780                 


Thr Gly Ser Leu Ala Leu Phe Tyr Arg Lys Val Tyr His Leu Ala Ser 
785                 790                 795                 800 


Val Arg Leu Arg Asp Leu Cys Leu Lys Leu Asp Val Ser Asn Glu Leu 
                805                 810                 815     


Arg Arg Lys Ile Trp Thr Cys Phe Glu Phe Thr Leu Val His Cys Pro 
            820                 825                 830         


Asp Leu Met Lys Asp Arg His Leu Asp Gln Leu Leu Leu Cys Ala Phe 
        835                 840                 845             


Tyr Ile Met Ala Lys Val Thr Lys Glu Glu Arg Thr Phe Gln Glu Ile 
    850                 855                 860                 


Met Lys Ser Tyr Arg Asn Gln Pro Gln Ala Asn Ser His Val Tyr Arg 
865                 870                 875                 880 


Ser Val Leu Leu Lys Ser Ile Pro Arg Glu Val Val Ala Tyr Asn Lys 
                885                 890                 895     


Asn Ile Asn Asp Asp Phe Glu Met Ile Asp Cys Asp Leu Glu Asp Ala 
            900                 905                 910         


Thr Lys Thr Pro Asp Cys Ser Ser Gly Pro Val Lys Glu Glu Arg Gly 
        915                 920                 925             


Asp Leu Ile Lys Phe Tyr Asn Thr Ile Tyr Val Gly Arg Val Lys Ser 
    930                 935                 940                 


Phe Ala Leu Lys Tyr Asp Leu Ala Asn Gln Asp His Met Met Asp Ala 
945                 950                 955                 960 


Pro Pro Leu Ser Pro Phe Pro His Ile Lys Gln Gln Pro Gly Ser Pro 
                965                 970                 975     


Arg Arg Ile Ser Gln Gln His Ser Ile Tyr Ile Ser Pro His Lys Asn 
            980                 985                 990         


Gly Ser Gly Leu Thr Pro Arg Ser  Ala Leu Leu Tyr Lys  Phe Asn Gly 
        995                 1000                 1005             


Ser Pro  Ser Lys Ser Leu Lys  Asp Ile Asn Asn Met  Ile Arg Gln 
    1010                 1015                 1020             


Gly Glu  Gln Arg Thr Lys Lys  Arg Val Ile Ala Ile  Asp Ser Asp 
    1025                 1030                 1035             


Ala Glu  Ser Pro Ala Lys Arg  Val Cys Gln Glu Asn  Asp Asp Val 
    1040                 1045                 1050             


Leu Leu  Lys Arg Leu Gln Asp  Val Val Ser Glu Arg  Ala Asn His 
    1055                 1060                 1065             


<210>  3892
<211>  3371
<212>  DNA
<213>  Homosapiens

<400>  3892
gcaggtggtt gtgggtagcg cgcctgggag ggagaaagaa gtcgggggcc gtggcgcgca     60

gcccgcgggg cctgaaggga tgttcgagga caagccccac gctgaggggg cggcggtggt    120

cgccgcagcc ggggaggcgc tacaggccct gtgccaggag ctgaacctgg acgaggggag    180

cgcggccgaa gccctggacg actttactgc catccgaggc aactacagcc tagagggaga    240

agttacacac tggttggcat gttcattata tgttgcatgc cgcaaaagca ttattcccac    300

ggttggaaag ggtatcatgg aaggcaactg tgtttcactt accagaatac tacgttcagc    360

taaattaagt ttaatacaat tttttagtaa aatgaagaaa tggatggaca tgtcaaatct    420

accacaagaa tttcgtgaac gtatagaaag gctagagaga aattttgagg tgtctactgt    480

aatattcaaa aaatatgagc caattttttt agatatattt caaaatccat atgaagaacc    540

accaaagtta ccacgaagcc ggaagcagag gaggattcct tgcagtgtta aggatctgtt    600

taatttctgt tggacacttt ttgtttatac taagggtaat tttcggatga ttggggatga    660

cttagtaaac tcttatcatt tacttctatg ctgcttggat ctgatttttg ccaatgcgat    720

tatgtgccca aatagacaag acttgctaaa tccatcattt aaaggtttac catctgattt    780

tcatactgct gactttacgg cttctgaaga gccaccctgc atcattgctg tactgtgtga    840

actgcatgat ggacttctcg tagaagcaaa aggaataaag gagcactact ttaagccata    900

tatttcaaaa ctctttgaca ggaagatatt aaaaggagaa tgcctcctgg acctttcaag    960

ttttactgat aatagcaaag cagtgaataa ggagtatgaa gagtatgttc taactgttgg   1020

tgattttgat gagaggatct ttttgggagc agacgcagaa gaggaaattg gaacacctcg   1080

aaagttcact cgtgacaccc cattagggaa actgacagca caggctaatg tggagtataa   1140

ccttcaacag cactttgaaa aaaaaaggtc atttgcacct tctaccccac tgaccggacg   1200

gagatattta cgagaaaaag aagcagtcat tactcctgtt gcatcagcca cccaaagtgt   1260

gagccggtta cagagtattg tggctggtct gaaaaatgca ccaagtgacc aacttataaa   1320

tatttttgaa tcttgtgtgc gtaatcctgt ggaaaacatt atgaaaatac taaaaggaat   1380

aggagagact ttctgtcaac actatactca atcaacagat gaacagccag gatctcacat   1440

agactttgct gtaaacagac taaagctggc agaaattttg tattataaaa tactagagac   1500

tgtaatggtt caggaaacac gaagacttca tggaatggac atgtcagttc ttttagagca   1560

agatatattt catcgttcct tgatggcttg ttgtttggaa attgtgctct ttgcctatag   1620

ctcacctcgt acttttcctt ggattattga agttctcaac ttgcaaccat tttactttta   1680

taaggttatt gaggtggtga tccgctcaga agaggggctc tcaagggaca tggtgaaaca   1740

cctaaacagc attgaagaac agattttgga gagtttagca tggagtcacg attctgcact   1800

gtgggaggct ctccaggttt ctgcaaacaa agttcctacc tgtgaagaag ttatattccc   1860

aaataacttt gaaacaggaa atggaggaaa tgtgcaggga catcttcccc tgatgccaat   1920

gtctcctcta atgcacccaa gagtcaagga agttcgaact gacagtggga gtcttcgaag   1980

agatatgcaa ccattgtctc caatttctgt ccatgaacgc tacagttctc ctaccgcagg   2040

gagtgctaag agaagactct ttggagagga ccccccaaag gaaatgctta tggacaagat   2100

cataacagaa ggaacaaaat tgaaaatcgc tccttcttca agcattactg ctgaaaatgt   2160

atcaatttta cctggtcaaa ctcttctaac aatggccaca gccccagtaa caggaacaac   2220

aggacataaa gttacaattc cattacatgg tgtcgcaaat gatgctggag agatcacact   2280

gatacctctt tccatgaata caaatcagga gtccaaagtc aagagtcctg tatcacttac   2340

tgctcattca ttaattggtg cttctccaaa acagaccaat ctgactaaag cacaagaggt   2400

acattcaact ggaataaaca ggccaaagag aactgggtcc ttagcactat tttacagaaa   2460

ggtctatcat ttggcaagtg tacgcttacg tgatctatgt ctaaaactgg atgtttcaaa   2520

tgagttacga aggaagatat ggacgtgttt tgaattcact ttagttcact gtcctgatct   2580

aatgaaagac aggcatttgg atcagctcct cctttgtgcc ttttatatca tggcaaaggt   2640

aacaaaagaa gaaagaactt ttcaagaaat tatgaaaagt tataggaatc agccccaagc   2700

taatagtcac gtatatagaa gtgttctgct gaaaagtatt ccaagagaag ttgtggcata   2760

taataaaaat ataaatgatg actttgaaat gatagattgt gacttagaag atgctacaaa   2820

aacacctgac tgttccagtg gaccagtgaa agaggaaaga ggtgatctta taaaatttta   2880

caatacaata tatgtaggaa gagtgaagtc atttgcactg aaatacgact tggcgaatca   2940

ggaccatatg atggatgctc caccactctc tccttttcca catattaaac aacagccagg   3000

ctcaccacgc cgcatttccc agcagcactc catttatatt tccccgcaca agaatgggtc   3060

aggccttaca ccaagaagcg ctctgctgta caagttcaat ggcagccctt ctaaggtaag   3120

gtgaataggc taaaagttgg atttcagatt aacagtcagt aactgttaat cctgcctctt   3180

tttttttttt tcttttttgg ccaagttact actatactaa taaaatatga aatgttaact   3240

atgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3360

aaaaaaaaaa a                                                        3371


<210>  3893
<211>  1014
<212>  PRT
<213>  Homosapiens

<400>  3893

Met Phe Glu Asp Lys Pro His Ala Glu Gly Ala Ala Val Val Ala Ala 
1               5                   10                  15      


Ala Gly Glu Ala Leu Gln Ala Leu Cys Gln Glu Leu Asn Leu Asp Glu 
            20                  25                  30          


Gly Ser Ala Ala Glu Ala Leu Asp Asp Phe Thr Ala Ile Arg Gly Asn 
        35                  40                  45              


Tyr Ser Leu Glu Gly Glu Val Thr His Trp Leu Ala Cys Ser Leu Tyr 
    50                  55                  60                  


Val Ala Cys Arg Lys Ser Ile Ile Pro Thr Val Gly Lys Gly Ile Met 
65                  70                  75                  80  


Glu Gly Asn Cys Val Ser Leu Thr Arg Ile Leu Arg Ser Ala Lys Leu 
                85                  90                  95      


Ser Leu Ile Gln Phe Phe Ser Lys Met Lys Lys Trp Met Asp Met Ser 
            100                 105                 110         


Asn Leu Pro Gln Glu Phe Arg Glu Arg Ile Glu Arg Leu Glu Arg Asn 
        115                 120                 125             


Phe Glu Val Ser Thr Val Ile Phe Lys Lys Tyr Glu Pro Ile Phe Leu 
    130                 135                 140                 


Asp Ile Phe Gln Asn Pro Tyr Glu Glu Pro Pro Lys Leu Pro Arg Ser 
145                 150                 155                 160 


Arg Lys Gln Arg Arg Ile Pro Cys Ser Val Lys Asp Leu Phe Asn Phe 
                165                 170                 175     


Cys Trp Thr Leu Phe Val Tyr Thr Lys Gly Asn Phe Arg Met Ile Gly 
            180                 185                 190         


Asp Asp Leu Val Asn Ser Tyr His Leu Leu Leu Cys Cys Leu Asp Leu 
        195                 200                 205             


Ile Phe Ala Asn Ala Ile Met Cys Pro Asn Arg Gln Asp Leu Leu Asn 
    210                 215                 220                 


Pro Ser Phe Lys Gly Leu Pro Ser Asp Phe His Thr Ala Asp Phe Thr 
225                 230                 235                 240 


Ala Ser Glu Glu Pro Pro Cys Ile Ile Ala Val Leu Cys Glu Leu His 
                245                 250                 255     


Asp Gly Leu Leu Val Glu Ala Lys Gly Ile Lys Glu His Tyr Phe Lys 
            260                 265                 270         


Pro Tyr Ile Ser Lys Leu Phe Asp Arg Lys Ile Leu Lys Gly Glu Cys 
        275                 280                 285             


Leu Leu Asp Leu Ser Ser Phe Thr Asp Asn Ser Lys Ala Val Asn Lys 
    290                 295                 300                 


Glu Tyr Glu Glu Tyr Val Leu Thr Val Gly Asp Phe Asp Glu Arg Ile 
305                 310                 315                 320 


Phe Leu Gly Ala Asp Ala Glu Glu Glu Ile Gly Thr Pro Arg Lys Phe 
                325                 330                 335     


Thr Arg Asp Thr Pro Leu Gly Lys Leu Thr Ala Gln Ala Asn Val Glu 
            340                 345                 350         


Tyr Asn Leu Gln Gln His Phe Glu Lys Lys Arg Ser Phe Ala Pro Ser 
        355                 360                 365             


Thr Pro Leu Thr Gly Arg Arg Tyr Leu Arg Glu Lys Glu Ala Val Ile 
    370                 375                 380                 


Thr Pro Val Ala Ser Ala Thr Gln Ser Val Ser Arg Leu Gln Ser Ile 
385                 390                 395                 400 


Val Ala Gly Leu Lys Asn Ala Pro Ser Asp Gln Leu Ile Asn Ile Phe 
                405                 410                 415     


Glu Ser Cys Val Arg Asn Pro Val Glu Asn Ile Met Lys Ile Leu Lys 
            420                 425                 430         


Gly Ile Gly Glu Thr Phe Cys Gln His Tyr Thr Gln Ser Thr Asp Glu 
        435                 440                 445             


Gln Pro Gly Ser His Ile Asp Phe Ala Val Asn Arg Leu Lys Leu Ala 
    450                 455                 460                 


Glu Ile Leu Tyr Tyr Lys Ile Leu Glu Thr Val Met Val Gln Glu Thr 
465                 470                 475                 480 


Arg Arg Leu His Gly Met Asp Met Ser Val Leu Leu Glu Gln Asp Ile 
                485                 490                 495     


Phe His Arg Ser Leu Met Ala Cys Cys Leu Glu Ile Val Leu Phe Ala 
            500                 505                 510         


Tyr Ser Ser Pro Arg Thr Phe Pro Trp Ile Ile Glu Val Leu Asn Leu 
        515                 520                 525             


Gln Pro Phe Tyr Phe Tyr Lys Val Ile Glu Val Val Ile Arg Ser Glu 
    530                 535                 540                 


Glu Gly Leu Ser Arg Asp Met Val Lys His Leu Asn Ser Ile Glu Glu 
545                 550                 555                 560 


Gln Ile Leu Glu Ser Leu Ala Trp Ser His Asp Ser Ala Leu Trp Glu 
                565                 570                 575     


Ala Leu Gln Val Ser Ala Asn Lys Val Pro Thr Cys Glu Glu Val Ile 
            580                 585                 590         


Phe Pro Asn Asn Phe Glu Thr Gly Asn Gly Gly Asn Val Gln Gly His 
        595                 600                 605             


Leu Pro Leu Met Pro Met Ser Pro Leu Met His Pro Arg Val Lys Glu 
    610                 615                 620                 


Val Arg Thr Asp Ser Gly Ser Leu Arg Arg Asp Met Gln Pro Leu Ser 
625                 630                 635                 640 


Pro Ile Ser Val His Glu Arg Tyr Ser Ser Pro Thr Ala Gly Ser Ala 
                645                 650                 655     


Lys Arg Arg Leu Phe Gly Glu Asp Pro Pro Lys Glu Met Leu Met Asp 
            660                 665                 670         


Lys Ile Ile Thr Glu Gly Thr Lys Leu Lys Ile Ala Pro Ser Ser Ser 
        675                 680                 685             


Ile Thr Ala Glu Asn Val Ser Ile Leu Pro Gly Gln Thr Leu Leu Thr 
    690                 695                 700                 


Met Ala Thr Ala Pro Val Thr Gly Thr Thr Gly His Lys Val Thr Ile 
705                 710                 715                 720 


Pro Leu His Gly Val Ala Asn Asp Ala Gly Glu Ile Thr Leu Ile Pro 
                725                 730                 735     


Leu Ser Met Asn Thr Asn Gln Glu Ser Lys Val Lys Ser Pro Val Ser 
            740                 745                 750         


Leu Thr Ala His Ser Leu Ile Gly Ala Ser Pro Lys Gln Thr Asn Leu 
        755                 760                 765             


Thr Lys Ala Gln Glu Val His Ser Thr Gly Ile Asn Arg Pro Lys Arg 
    770                 775                 780                 


Thr Gly Ser Leu Ala Leu Phe Tyr Arg Lys Val Tyr His Leu Ala Ser 
785                 790                 795                 800 


Val Arg Leu Arg Asp Leu Cys Leu Lys Leu Asp Val Ser Asn Glu Leu 
                805                 810                 815     


Arg Arg Lys Ile Trp Thr Cys Phe Glu Phe Thr Leu Val His Cys Pro 
            820                 825                 830         


Asp Leu Met Lys Asp Arg His Leu Asp Gln Leu Leu Leu Cys Ala Phe 
        835                 840                 845             


Tyr Ile Met Ala Lys Val Thr Lys Glu Glu Arg Thr Phe Gln Glu Ile 
    850                 855                 860                 


Met Lys Ser Tyr Arg Asn Gln Pro Gln Ala Asn Ser His Val Tyr Arg 
865                 870                 875                 880 


Ser Val Leu Leu Lys Ser Ile Pro Arg Glu Val Val Ala Tyr Asn Lys 
                885                 890                 895     


Asn Ile Asn Asp Asp Phe Glu Met Ile Asp Cys Asp Leu Glu Asp Ala 
            900                 905                 910         


Thr Lys Thr Pro Asp Cys Ser Ser Gly Pro Val Lys Glu Glu Arg Gly 
        915                 920                 925             


Asp Leu Ile Lys Phe Tyr Asn Thr Ile Tyr Val Gly Arg Val Lys Ser 
    930                 935                 940                 


Phe Ala Leu Lys Tyr Asp Leu Ala Asn Gln Asp His Met Met Asp Ala 
945                 950                 955                 960 


Pro Pro Leu Ser Pro Phe Pro His Ile Lys Gln Gln Pro Gly Ser Pro 
                965                 970                 975     


Arg Arg Ile Ser Gln Gln His Ser Ile Tyr Ile Ser Pro His Lys Asn 
            980                 985                 990         


Gly Ser Gly Leu Thr Pro Arg Ser  Ala Leu Leu Tyr Lys  Phe Asn Gly 
        995                 1000                 1005             


Ser Pro  Ser Lys Val Arg 
    1010                 


<210>  3894
<211>  3481
<212>  DNA
<213>  Homosapiens

<400>  3894
accaaccccg ccaggtcgcg ggcactccca ccagctcgca gccctccttc ggaccctcga     60

tccgagagcg ccccagccag agcttgtgcc catgcccctg tcccgcaggg gaaggggatc    120

ccgcctggcc ggctctcgag cggcgactag taacctcccg cgggcgacag ccctctcccc    180

aaagagtgcc ggccgcgggg ccctgtctat aagccacgcg caactcctca cccggcggcg    240

ccattcctcc gagcaggtcc cgccggagtc cgagccgcgg gctgacttcc gctcgggaaa    300

gtggctccaa gagcccgcca caggggacgc cagggactcg cggcaggctc tgcgggccag    360

gatgagttct aagcacagga tctgtagtca ggaagaagta gtgatcccct gtgcctatga    420

cagtgattca gaaagtgtgg atttggagct gagcaactta gagattatta aaaaaggctc    480

aagtagcatt gaactgacag acttggacat ccctgacatc cctggactcc attgtgagcc    540

cctgtcacat agccccagac acctgaccca acaggacccg ctcagtgagg ccattgttga    600

gaaactgatc cagtccatcc agaaggtttt caatggtgag ctaaagggtg aacttgaaaa    660

gctgaaattc ctaggagatc tgtcttctct cagccaagct ttaccttatg atgaaaccgc    720

aaaatcattc attcacagcc acatagcaga cattgtgcat accttaaatg tactggtaca    780

agaggaacgc ccgcattctc tgtccagttc catgcgccag gaggtctttg tcaccatcgc    840

tgatctcagt taccaagatg tccatttgct gttgggctct gaagatcgag ctgagttgtt    900

cagtcttacc atcaagagta taatcactct gccctctgta aggaccctta cccagataca    960

ggaaatcatg cccaatggga cctgcaacac agagtgtctt tacaggcaga cgtttcaggc   1020

attctctgag atgctccaga gtttggtggt aaaagaccca catttggaaa atcttgacac   1080

cattattaag cacttggtcc cctggttaca gtcagtcaaa gaccatgagc gggaacgggc   1140

cacggccagc atggctcaag ttctgaagtg cctatccaaa catctcaact tgaagcttcc   1200

actgcgattc caaagacttg gacacctagt ggctctgatg gcactgctct gtggggaccc   1260

acaggaaaag gtggctgagg aggctgcaga gggcattcac tccctgctgc atatcaccct   1320

gaggctgaag tatatcactc atgacaagaa agatcagcaa aacttgaaaa gagcattgac   1380

aaaatgtcga gaattcctgg agctccacag ctctgccgct aaatgcttct acaactgtcc   1440

cttcagaatt gcccaggtct ttgaaggttt tcttgattca aatgagctct gccagtttat   1500

aatgactaca tttgataccc tgaaaaccct gaaacatccc tgcatccagc gatcagcagg   1560

agaattactg ctaactttgg cgaaaaatac agagtcccaa tttgagaagg tgccagaaat   1620

tatgggagtt atctgtgccc agttatccat aatcagccag cctagagtcc gccaacaaat   1680

cataaatacc gtgagtttat ttatatccag acccaagtac acagatatag tgctcagctt   1740

ccttctgtgt catccagtgc cgtataacag gcacctggct gaggtgtgga gaatgctgtc   1800

ggtggagctt cccagcacga cctggattct gtggaggctc ctgaggaagc tgcagaaatg   1860

ccataatgag cctgcacagg agaagatggc atatgtggct gtggctgcaa cagatgccct   1920

ttatgaggtg tttttgggaa acaggcttcg agcagctacg ttccgactct ttcctcagct   1980

tctcatgaca ctgcttatcc agattcatca cagcatcggc ctcaccatgt ctgatgtcga   2040

catcccaagt ggcctgtaca cagaacagga agtgccttca gaggtcaccc ctttgtgctt   2100

tgccatgcag gctacaaaga ctctcctcct cagaacatgc tgcttgcagg aattcaacat   2160

catggaaaag aataaaggat gggctctcct gggaggaaaa gatggccatc ttcagggact   2220

atttctcctt gccaacgcat tgctggaaag aaatcagctc cttgcacaga aggtcatgta   2280

cttattagtc cctcttctta accgagggaa tgataaacat aaactcacat ctgcaggctt   2340

ttttgtggag cttctccgga gtccagtggc caagagactg cccagcatat actctgttgc   2400

ccgctttaaa gactggctac aagatggaaa tcatctcttt agaattctcg gcctgagggg   2460

actgtacaat cttgttggac accaggagat gagagaagac atcaagagcc tgttgccata   2520

cattgtagac agcttgcgtg aaaccgatga gaagatcgtt ctgtcagcca tccagatact   2580

cctgcaactt gttagaacaa tggatttcac taccctggct gccatgatga ggaccctgtt   2640

ctccttattt ggtgatgtga gatctgatgt tcatcgtttc tccgtgactc tctttggagc   2700

cgccataaag tctgtaaaaa acccagataa gaagagtata gagaaccaag tcctggacag   2760

cttggtccca ctacttctgt attctcagga tgaaaatgat gcagtagctg aggagagcag   2820

gcaagtccta actatatgtg cccagttcct gaagtggaag ctgccccaag aagtgtactc   2880

caaagatccc tggcacatca aacctactga agcaggaaca atctgcagat tctttgaaaa   2940

aaagtgcaag gggaaaatta acatcctaga acaaacactg atgtactcca agaacccaaa   3000

acttcccatc agaagatcag cagtcttgtt tgtaggcctt ttatcgaagt acatggatca   3060

caatgagctc aggaggatgg gtactgactg gatagaggac gatctgagag acctgctgtg   3120

tgaccctgag ccctcgctgt gcatcatcgc ttcccagact ctgttactag tccagatggc   3180

gagggccgaa ccaaaaccta agcagagagt gaactggttg cagaagctca tgggcaggtc   3240

ctctgcctag aaacacaagg caagcaacat cagagacaga atcttgctat gttgtgcggc   3300

aagctagtct tgaactcatg gcctcaagtc atcctcctgt gtcagcctcc caaagtgctg   3360

ggattacaag catgcaccac ggcacccagc agaattccag tcttgagaaa caggtcaagg   3420

acagcttcaa aagagattct aaataaatgt taatgttaca atgttaaaaa aaaaaaaaaa   3480

a                                                                   3481


<210>  3895
<211>  1052
<212>  PRT
<213>  Homosapiens

<400>  3895

Met Pro Leu Ser Arg Arg Gly Arg Gly Ser Arg Leu Ala Gly Ser Arg 
1               5                   10                  15      


Ala Ala Thr Ser Asn Leu Pro Arg Ala Thr Ala Leu Ser Pro Lys Ser 
            20                  25                  30          


Ala Gly Arg Gly Ala Leu Ser Ile Ser His Ala Gln Leu Leu Thr Arg 
        35                  40                  45              


Arg Arg His Ser Ser Glu Gln Val Pro Pro Glu Ser Glu Pro Arg Ala 
    50                  55                  60                  


Asp Phe Arg Ser Gly Lys Trp Leu Gln Glu Pro Ala Thr Gly Asp Ala 
65                  70                  75                  80  


Arg Asp Ser Arg Gln Ala Leu Arg Ala Arg Met Ser Ser Lys His Arg 
                85                  90                  95      


Ile Cys Ser Gln Glu Glu Val Val Ile Pro Cys Ala Tyr Asp Ser Asp 
            100                 105                 110         


Ser Glu Ser Val Asp Leu Glu Leu Ser Asn Leu Glu Ile Ile Lys Lys 
        115                 120                 125             


Gly Ser Ser Ser Ile Glu Leu Thr Asp Leu Asp Ile Pro Asp Ile Pro 
    130                 135                 140                 


Gly Leu His Cys Glu Pro Leu Ser His Ser Pro Arg His Leu Thr Gln 
145                 150                 155                 160 


Gln Asp Pro Leu Ser Glu Ala Ile Val Glu Lys Leu Ile Gln Ser Ile 
                165                 170                 175     


Gln Lys Val Phe Asn Gly Glu Leu Lys Gly Glu Leu Glu Lys Leu Lys 
            180                 185                 190         


Phe Leu Gly Asp Leu Ser Ser Leu Ser Gln Ala Leu Pro Tyr Asp Glu 
        195                 200                 205             


Thr Ala Lys Ser Phe Ile His Ser His Ile Ala Asp Ile Val His Thr 
    210                 215                 220                 


Leu Asn Val Leu Val Gln Glu Glu Arg Pro His Ser Leu Ser Ser Ser 
225                 230                 235                 240 


Met Arg Gln Glu Val Phe Val Thr Ile Ala Asp Leu Ser Tyr Gln Asp 
                245                 250                 255     


Val His Leu Leu Leu Gly Ser Glu Asp Arg Ala Glu Leu Phe Ser Leu 
            260                 265                 270         


Thr Ile Lys Ser Ile Ile Thr Leu Pro Ser Val Arg Thr Leu Thr Gln 
        275                 280                 285             


Ile Gln Glu Ile Met Pro Asn Gly Thr Cys Asn Thr Glu Cys Leu Tyr 
    290                 295                 300                 


Arg Gln Thr Phe Gln Ala Phe Ser Glu Met Leu Gln Ser Leu Val Val 
305                 310                 315                 320 


Lys Asp Pro His Leu Glu Asn Leu Asp Thr Ile Ile Lys His Leu Val 
                325                 330                 335     


Pro Trp Leu Gln Ser Val Lys Asp His Glu Arg Glu Arg Ala Thr Ala 
            340                 345                 350         


Ser Met Ala Gln Val Leu Lys Cys Leu Ser Lys His Leu Asn Leu Lys 
        355                 360                 365             


Leu Pro Leu Arg Phe Gln Arg Leu Gly His Leu Val Ala Leu Met Ala 
    370                 375                 380                 


Leu Leu Cys Gly Asp Pro Gln Glu Lys Val Ala Glu Glu Ala Ala Glu 
385                 390                 395                 400 


Gly Ile His Ser Leu Leu His Ile Thr Leu Arg Leu Lys Tyr Ile Thr 
                405                 410                 415     


His Asp Lys Lys Asp Gln Gln Asn Leu Lys Arg Ala Leu Thr Lys Cys 
            420                 425                 430         


Arg Glu Phe Leu Glu Leu His Ser Ser Ala Ala Lys Cys Phe Tyr Asn 
        435                 440                 445             


Cys Pro Phe Arg Ile Ala Gln Val Phe Glu Gly Phe Leu Asp Ser Asn 
    450                 455                 460                 


Glu Leu Cys Gln Phe Ile Met Thr Thr Phe Asp Thr Leu Lys Thr Leu 
465                 470                 475                 480 


Lys His Pro Cys Ile Gln Arg Ser Ala Gly Glu Leu Leu Leu Thr Leu 
                485                 490                 495     


Ala Lys Asn Thr Glu Ser Gln Phe Glu Lys Val Pro Glu Ile Met Gly 
            500                 505                 510         


Val Ile Cys Ala Gln Leu Ser Ile Ile Ser Gln Pro Arg Val Arg Gln 
        515                 520                 525             


Gln Ile Ile Asn Thr Val Ser Leu Phe Ile Ser Arg Pro Lys Tyr Thr 
    530                 535                 540                 


Asp Ile Val Leu Ser Phe Leu Leu Cys His Pro Val Pro Tyr Asn Arg 
545                 550                 555                 560 


His Leu Ala Glu Val Trp Arg Met Leu Ser Val Glu Leu Pro Ser Thr 
                565                 570                 575     


Thr Trp Ile Leu Trp Arg Leu Leu Arg Lys Leu Gln Lys Cys His Asn 
            580                 585                 590         


Glu Pro Ala Gln Glu Lys Met Ala Tyr Val Ala Val Ala Ala Thr Asp 
        595                 600                 605             


Ala Leu Tyr Glu Val Phe Leu Gly Asn Arg Leu Arg Ala Ala Thr Phe 
    610                 615                 620                 


Arg Leu Phe Pro Gln Leu Leu Met Thr Leu Leu Ile Gln Ile His His 
625                 630                 635                 640 


Ser Ile Gly Leu Thr Met Ser Asp Val Asp Ile Pro Ser Gly Leu Tyr 
                645                 650                 655     


Thr Glu Gln Glu Val Pro Ser Glu Val Thr Pro Leu Cys Phe Ala Met 
            660                 665                 670         


Gln Ala Thr Lys Thr Leu Leu Leu Arg Thr Cys Cys Leu Gln Glu Phe 
        675                 680                 685             


Asn Ile Met Glu Lys Asn Lys Gly Trp Ala Leu Leu Gly Gly Lys Asp 
    690                 695                 700                 


Gly His Leu Gln Gly Leu Phe Leu Leu Ala Asn Ala Leu Leu Glu Arg 
705                 710                 715                 720 


Asn Gln Leu Leu Ala Gln Lys Val Met Tyr Leu Leu Val Pro Leu Leu 
                725                 730                 735     


Asn Arg Gly Asn Asp Lys His Lys Leu Thr Ser Ala Gly Phe Phe Val 
            740                 745                 750         


Glu Leu Leu Arg Ser Pro Val Ala Lys Arg Leu Pro Ser Ile Tyr Ser 
        755                 760                 765             


Val Ala Arg Phe Lys Asp Trp Leu Gln Asp Gly Asn His Leu Phe Arg 
    770                 775                 780                 


Ile Leu Gly Leu Arg Gly Leu Tyr Asn Leu Val Gly His Gln Glu Met 
785                 790                 795                 800 


Arg Glu Asp Ile Lys Ser Leu Leu Pro Tyr Ile Val Asp Ser Leu Arg 
                805                 810                 815     


Glu Thr Asp Glu Lys Ile Val Leu Ser Ala Ile Gln Ile Leu Leu Gln 
            820                 825                 830         


Leu Val Arg Thr Met Asp Phe Thr Thr Leu Ala Ala Met Met Arg Thr 
        835                 840                 845             


Leu Phe Ser Leu Phe Gly Asp Val Arg Ser Asp Val His Arg Phe Ser 
    850                 855                 860                 


Val Thr Leu Phe Gly Ala Ala Ile Lys Ser Val Lys Asn Pro Asp Lys 
865                 870                 875                 880 


Lys Ser Ile Glu Asn Gln Val Leu Asp Ser Leu Val Pro Leu Leu Leu 
                885                 890                 895     


Tyr Ser Gln Asp Glu Asn Asp Ala Val Ala Glu Glu Ser Arg Gln Val 
            900                 905                 910         


Leu Thr Ile Cys Ala Gln Phe Leu Lys Trp Lys Leu Pro Gln Glu Val 
        915                 920                 925             


Tyr Ser Lys Asp Pro Trp His Ile Lys Pro Thr Glu Ala Gly Thr Ile 
    930                 935                 940                 


Cys Arg Phe Phe Glu Lys Lys Cys Lys Gly Lys Ile Asn Ile Leu Glu 
945                 950                 955                 960 


Gln Thr Leu Met Tyr Ser Lys Asn Pro Lys Leu Pro Ile Arg Arg Ser 
                965                 970                 975     


Ala Val Leu Phe Val Gly Leu Leu Ser Lys Tyr Met Asp His Asn Glu 
            980                 985                 990         


Leu Arg Arg Met Gly Thr Asp Trp  Ile Glu Asp Asp Leu  Arg Asp Leu 
        995                 1000                 1005             


Leu Cys  Asp Pro Glu Pro Ser  Leu Cys Ile Ile Ala  Ser Gln Thr 
    1010                 1015                 1020             


Leu Leu  Leu Val Gln Met Ala  Arg Ala Glu Pro Lys  Pro Lys Gln 
    1025                 1030                 1035             


Arg Val  Asn Trp Leu Gln Lys  Leu Met Gly Arg Ser  Ser Ala 
    1040                 1045                 1050         


<210>  3896
<211>  2133
<212>  DNA
<213>  Homosapiens

<400>  3896
accaaccccg ccaggtcgcg ggcactccca ccagctcgca gccctccttc ggaccctcga     60

tccgagagcg ccccagccag agcttgtgcc catgcccctg tcccgcaggg gaaggggatc    120

ccgcctggcc ggctctcgag cggcgactag taacctcccg cgggcgacag ccctctcccc    180

aaagagtgcc ggccgcgggg ccctgtctat aagccacgcg caactcctca cccggcggcg    240

ccattcctcc gagcaggtcc cgccggagtc cgagccgcgg gctgacttcc gctcgggaaa    300

gtggctccaa gagcccgcca caggggacgc cagggactcg cggcaggctc tgcgggccag    360

gatgagttct aagcacagga tctgtagtca ggaagaagta gtgatcccct gtgcctatga    420

cagtgattca gaaagtgtgg atttggagct gagcaactta gagattatta aaaaaggctc    480

aagtagcatt gaactgacag acttggacat ccctgacatc cctggactcc attgtgagcc    540

cctgtcacat agccccagac acctgaccca acaggacccg ctcagtgagg ccattgttga    600

gaaactgatc cagtccatcc agaaggtttt caatggtgag ctaaagggtg aacttgaaaa    660

gctgaaattc ctaggagatc tgtcttctct cagccaagct ttaccttatg atgaaaccgc    720

aaaatcattc attcacagcc acatagcaga cattgtgcat accttaaatg tactggtaca    780

agaggaacgc ccgcattctc tgtccagttc catgcgccag gaggtctttg tcaccatcgc    840

tgatctcagt taccaagatg tccatttgct gttgggctct gaagatcgag ctgagttgtt    900

cagtcttacc atcaagagta taatcactct gccctctgta aggaccctta cccagataca    960

ggaaatcatg cccaatggga cctgcaacac agagtgtctt tacaggcaga cgtttcaggc   1020

attctctgag atgctccaga gtttggtggt aaaagaccca catttggaaa atcttgacac   1080

cattattaag cacttggtcc cctggttaca gtcagtcaaa gaccatgagc gggaacgggc   1140

cacggccagc atggctcaag ttctgaagtg cctatccaaa catctcaact tgaagcttcc   1200

actgcgattc caaagacttg gacacctagt ggctctgatg gcactgctct gtggggaccc   1260

acaggaaaag gtggctgagg aggctgcaga gggcattcac tccctgctgc atatcaccct   1320

gaggctgaag tatatcactc atgacaagaa agatcagcaa aacttgaaaa gagcattgac   1380

aaaatgtcga gaattcctgg agctccacag ctctgccgct aaatgcttct acaactgtcc   1440

cttcagaatt gcccaggtct ttgaaggttt tcttgattca aatgagctct gccagtttat   1500

aatgactaca tttgataccc tgaaaaccct gaaacatccc tgcatccagc gatcagcagg   1560

agaattactg ctaactttgg cgaaaaatac agagtcccaa tttgagaagg tgccagaaat   1620

tatgggagtt atctgtgccc agttatccat aatcagccag cctagagtcc gccaacaaat   1680

cataaatacc gtgagtttat ttatatccag acccaagtac acagatatag tgctcagctt   1740

ccttctgtgt catccagtgc cgtataacag gcacctggct gaggtgtgga gaatgctgtc   1800

ggtggagctt cccagcacga cctggattct gtggaggctc ctgaggaagc tgcagaaatg   1860

ccataatgag cctgcacagg agaagatggc atatgtggct gtggctgtaa gcccttgagc   1920

tttgcccctc taatgtcagc ccctcccagg atgactgacc ccacacccca gtggagagtg   1980

ttccttttgg tccctctcaa agcctgcatc tgtcatccat ttataagtct acagtgtttc   2040

tgccaaggga ttgacatgga gggagctggg gagagtgaag gagtcagaat gccttaatac   2100

aaactcgtcc aacctgcaaa aaaaaaaaaa aaa                                2133


<210>  3897
<211>  608
<212>  PRT
<213>  Homosapiens

<400>  3897

Met Pro Leu Ser Arg Arg Gly Arg Gly Ser Arg Leu Ala Gly Ser Arg 
1               5                   10                  15      


Ala Ala Thr Ser Asn Leu Pro Arg Ala Thr Ala Leu Ser Pro Lys Ser 
            20                  25                  30          


Ala Gly Arg Gly Ala Leu Ser Ile Ser His Ala Gln Leu Leu Thr Arg 
        35                  40                  45              


Arg Arg His Ser Ser Glu Gln Val Pro Pro Glu Ser Glu Pro Arg Ala 
    50                  55                  60                  


Asp Phe Arg Ser Gly Lys Trp Leu Gln Glu Pro Ala Thr Gly Asp Ala 
65                  70                  75                  80  


Arg Asp Ser Arg Gln Ala Leu Arg Ala Arg Met Ser Ser Lys His Arg 
                85                  90                  95      


Ile Cys Ser Gln Glu Glu Val Val Ile Pro Cys Ala Tyr Asp Ser Asp 
            100                 105                 110         


Ser Glu Ser Val Asp Leu Glu Leu Ser Asn Leu Glu Ile Ile Lys Lys 
        115                 120                 125             


Gly Ser Ser Ser Ile Glu Leu Thr Asp Leu Asp Ile Pro Asp Ile Pro 
    130                 135                 140                 


Gly Leu His Cys Glu Pro Leu Ser His Ser Pro Arg His Leu Thr Gln 
145                 150                 155                 160 


Gln Asp Pro Leu Ser Glu Ala Ile Val Glu Lys Leu Ile Gln Ser Ile 
                165                 170                 175     


Gln Lys Val Phe Asn Gly Glu Leu Lys Gly Glu Leu Glu Lys Leu Lys 
            180                 185                 190         


Phe Leu Gly Asp Leu Ser Ser Leu Ser Gln Ala Leu Pro Tyr Asp Glu 
        195                 200                 205             


Thr Ala Lys Ser Phe Ile His Ser His Ile Ala Asp Ile Val His Thr 
    210                 215                 220                 


Leu Asn Val Leu Val Gln Glu Glu Arg Pro His Ser Leu Ser Ser Ser 
225                 230                 235                 240 


Met Arg Gln Glu Val Phe Val Thr Ile Ala Asp Leu Ser Tyr Gln Asp 
                245                 250                 255     


Val His Leu Leu Leu Gly Ser Glu Asp Arg Ala Glu Leu Phe Ser Leu 
            260                 265                 270         


Thr Ile Lys Ser Ile Ile Thr Leu Pro Ser Val Arg Thr Leu Thr Gln 
        275                 280                 285             


Ile Gln Glu Ile Met Pro Asn Gly Thr Cys Asn Thr Glu Cys Leu Tyr 
    290                 295                 300                 


Arg Gln Thr Phe Gln Ala Phe Ser Glu Met Leu Gln Ser Leu Val Val 
305                 310                 315                 320 


Lys Asp Pro His Leu Glu Asn Leu Asp Thr Ile Ile Lys His Leu Val 
                325                 330                 335     


Pro Trp Leu Gln Ser Val Lys Asp His Glu Arg Glu Arg Ala Thr Ala 
            340                 345                 350         


Ser Met Ala Gln Val Leu Lys Cys Leu Ser Lys His Leu Asn Leu Lys 
        355                 360                 365             


Leu Pro Leu Arg Phe Gln Arg Leu Gly His Leu Val Ala Leu Met Ala 
    370                 375                 380                 


Leu Leu Cys Gly Asp Pro Gln Glu Lys Val Ala Glu Glu Ala Ala Glu 
385                 390                 395                 400 


Gly Ile His Ser Leu Leu His Ile Thr Leu Arg Leu Lys Tyr Ile Thr 
                405                 410                 415     


His Asp Lys Lys Asp Gln Gln Asn Leu Lys Arg Ala Leu Thr Lys Cys 
            420                 425                 430         


Arg Glu Phe Leu Glu Leu His Ser Ser Ala Ala Lys Cys Phe Tyr Asn 
        435                 440                 445             


Cys Pro Phe Arg Ile Ala Gln Val Phe Glu Gly Phe Leu Asp Ser Asn 
    450                 455                 460                 


Glu Leu Cys Gln Phe Ile Met Thr Thr Phe Asp Thr Leu Lys Thr Leu 
465                 470                 475                 480 


Lys His Pro Cys Ile Gln Arg Ser Ala Gly Glu Leu Leu Leu Thr Leu 
                485                 490                 495     


Ala Lys Asn Thr Glu Ser Gln Phe Glu Lys Val Pro Glu Ile Met Gly 
            500                 505                 510         


Val Ile Cys Ala Gln Leu Ser Ile Ile Ser Gln Pro Arg Val Arg Gln 
        515                 520                 525             


Gln Ile Ile Asn Thr Val Ser Leu Phe Ile Ser Arg Pro Lys Tyr Thr 
    530                 535                 540                 


Asp Ile Val Leu Ser Phe Leu Leu Cys His Pro Val Pro Tyr Asn Arg 
545                 550                 555                 560 


His Leu Ala Glu Val Trp Arg Met Leu Ser Val Glu Leu Pro Ser Thr 
                565                 570                 575     


Thr Trp Ile Leu Trp Arg Leu Leu Arg Lys Leu Gln Lys Cys His Asn 
            580                 585                 590         


Glu Pro Ala Gln Glu Lys Met Ala Tyr Val Ala Val Ala Val Ser Pro 
        595                 600                 605             


<210>  3898
<211>  2028
<212>  DNA
<213>  Homosapiens

<400>  3898
accaaccccg ccaggtcgcg ggcactccca ccagctcgca gccctccttc ggaccctcga     60

tccgagagcg ccccagccag agcttgtgcc catgcccctg tcccgcaggg gaaggggatc    120

ccgcctggcc ggctctcgag cggcgactag taacctcccg cgggcgacag ccctctcccc    180

aaagagtgcc ggccgcgggg ccctgtctat aagccacgcg caactcctca cccggcggcg    240

ccattcctcc gagcaggtcc cgccggagtc cgagccgcgg gctgacttcc gctcgggaaa    300

gtggctccaa gagcccgcca caggggacgc cagggactcg cggcaggctc tgcgggccag    360

gatgagttct aagcacagga tctgtagtca ggaagaagta gtgatcccct gtgcctatga    420

cagtgattca gaaagtgtgg atttggagct gagcaactta gagattatta aaaaaggctc    480

aagtagcatt gaactgacag acttggacat ccctgacatc cctggactcc attgtgagcc    540

cctgtcacat agccccagac acctgaccca acaggacccg ctcagtgagg ccattgttga    600

gaaactgatc cagtccatcc agaaggtttt caatggtgag ctaaagggtg aacttgaaaa    660

gctgaaattc ctaggagatc tgtcttctct cagccaagct ttaccttatg atgaaaccgc    720

aaaatcattc attcacagcc acatagcaga cattgtgcat accttaaatg tactggtaca    780

agaggaacgc ccgcattctc tgtccagttc catgcgccag gaggtctttg tcaccatcgc    840

tgatctcagt taccaagatg tccatttgct gttgggctct gaagatcgag ctgagttgtt    900

cagtcttacc atcaagagta taatcactct gccctctgta aggaccctta cccagataca    960

ggaaatcatg cccaatggga cctgcaacac agagtgtctt tacaggcaga cgtttcaggc   1020

attctctgag atgctccaga gtttggtggt aaaagaccca catttggaaa atcttgacac   1080

cattattaag cttccactgc gattccaaag acttggacac ctagtggctc tgatggcact   1140

gctctgtggg gacccacagg aaaaggtggc tgaggaggct gcagagggca ttcactccct   1200

gctgcatatc accctgaggc tgaagtatat cactcatgac aagaaagatc agcaaaactt   1260

gaaaagagca ttgacaaaat gtcgagaatt cctggagctc cacagctctg ccgctaaatg   1320

cttctacaac tgtcccttca gaattgccca ggtctttgaa ggttttcttg attcaaatga   1380

gctctgccag tttataatga ctacatttga taccctgaaa aacctgaaac atccctgcat   1440

ccagcgatca gcaggagaat tactgctaac tttggcgaaa aatacagagt cccaatttga   1500

gaaggtgcca gaaattatgg gagttatctg tgcccagtta tccataatca gccagcctag   1560

agtccgccaa caaatcataa ataccgtgag tttatttata tccagaccca agtacacaga   1620

tatagtgctc agcttccttc tgtgtcatcc agtgccgtat aacaggcacc tggctgaggt   1680

gtggagaatg ctgtcggtgg agcttcccag cacgacctgg attctgtgga ggctcctgag   1740

gaagctgcag aaatgccata atgagcctgc acaggagaag atggcatatg tggctgtggc   1800

tgtaagccct tgagctttgc ccctctaatg tcagcccctc ccaggatgac tgaccccaca   1860

ccccagtgga gagtgttcct tttggtccct ctcaaagcct gcatctgtca tccatttata   1920

agtctacagt gtttctgcca agggattgac atggagggag ctggggagag tgaaggagtc   1980

agaatgcctt aatacaaact cgtccaacct gcaaaaaaaa aaaaaaaa                2028


<210>  3899
<211>  573
<212>  PRT
<213>  Homosapiens

<400>  3899

Met Pro Leu Ser Arg Arg Gly Arg Gly Ser Arg Leu Ala Gly Ser Arg 
1               5                   10                  15      


Ala Ala Thr Ser Asn Leu Pro Arg Ala Thr Ala Leu Ser Pro Lys Ser 
            20                  25                  30          


Ala Gly Arg Gly Ala Leu Ser Ile Ser His Ala Gln Leu Leu Thr Arg 
        35                  40                  45              


Arg Arg His Ser Ser Glu Gln Val Pro Pro Glu Ser Glu Pro Arg Ala 
    50                  55                  60                  


Asp Phe Arg Ser Gly Lys Trp Leu Gln Glu Pro Ala Thr Gly Asp Ala 
65                  70                  75                  80  


Arg Asp Ser Arg Gln Ala Leu Arg Ala Arg Met Ser Ser Lys His Arg 
                85                  90                  95      


Ile Cys Ser Gln Glu Glu Val Val Ile Pro Cys Ala Tyr Asp Ser Asp 
            100                 105                 110         


Ser Glu Ser Val Asp Leu Glu Leu Ser Asn Leu Glu Ile Ile Lys Lys 
        115                 120                 125             


Gly Ser Ser Ser Ile Glu Leu Thr Asp Leu Asp Ile Pro Asp Ile Pro 
    130                 135                 140                 


Gly Leu His Cys Glu Pro Leu Ser His Ser Pro Arg His Leu Thr Gln 
145                 150                 155                 160 


Gln Asp Pro Leu Ser Glu Ala Ile Val Glu Lys Leu Ile Gln Ser Ile 
                165                 170                 175     


Gln Lys Val Phe Asn Gly Glu Leu Lys Gly Glu Leu Glu Lys Leu Lys 
            180                 185                 190         


Phe Leu Gly Asp Leu Ser Ser Leu Ser Gln Ala Leu Pro Tyr Asp Glu 
        195                 200                 205             


Thr Ala Lys Ser Phe Ile His Ser His Ile Ala Asp Ile Val His Thr 
    210                 215                 220                 


Leu Asn Val Leu Val Gln Glu Glu Arg Pro His Ser Leu Ser Ser Ser 
225                 230                 235                 240 


Met Arg Gln Glu Val Phe Val Thr Ile Ala Asp Leu Ser Tyr Gln Asp 
                245                 250                 255     


Val His Leu Leu Leu Gly Ser Glu Asp Arg Ala Glu Leu Phe Ser Leu 
            260                 265                 270         


Thr Ile Lys Ser Ile Ile Thr Leu Pro Ser Val Arg Thr Leu Thr Gln 
        275                 280                 285             


Ile Gln Glu Ile Met Pro Asn Gly Thr Cys Asn Thr Glu Cys Leu Tyr 
    290                 295                 300                 


Arg Gln Thr Phe Gln Ala Phe Ser Glu Met Leu Gln Ser Leu Val Val 
305                 310                 315                 320 


Lys Asp Pro His Leu Glu Asn Leu Asp Thr Ile Ile Lys Leu Pro Leu 
                325                 330                 335     


Arg Phe Gln Arg Leu Gly His Leu Val Ala Leu Met Ala Leu Leu Cys 
            340                 345                 350         


Gly Asp Pro Gln Glu Lys Val Ala Glu Glu Ala Ala Glu Gly Ile His 
        355                 360                 365             


Ser Leu Leu His Ile Thr Leu Arg Leu Lys Tyr Ile Thr His Asp Lys 
    370                 375                 380                 


Lys Asp Gln Gln Asn Leu Lys Arg Ala Leu Thr Lys Cys Arg Glu Phe 
385                 390                 395                 400 


Leu Glu Leu His Ser Ser Ala Ala Lys Cys Phe Tyr Asn Cys Pro Phe 
                405                 410                 415     


Arg Ile Ala Gln Val Phe Glu Gly Phe Leu Asp Ser Asn Glu Leu Cys 
            420                 425                 430         


Gln Phe Ile Met Thr Thr Phe Asp Thr Leu Lys Asn Leu Lys His Pro 
        435                 440                 445             


Cys Ile Gln Arg Ser Ala Gly Glu Leu Leu Leu Thr Leu Ala Lys Asn 
    450                 455                 460                 


Thr Glu Ser Gln Phe Glu Lys Val Pro Glu Ile Met Gly Val Ile Cys 
465                 470                 475                 480 


Ala Gln Leu Ser Ile Ile Ser Gln Pro Arg Val Arg Gln Gln Ile Ile 
                485                 490                 495     


Asn Thr Val Ser Leu Phe Ile Ser Arg Pro Lys Tyr Thr Asp Ile Val 
            500                 505                 510         


Leu Ser Phe Leu Leu Cys His Pro Val Pro Tyr Asn Arg His Leu Ala 
        515                 520                 525             


Glu Val Trp Arg Met Leu Ser Val Glu Leu Pro Ser Thr Thr Trp Ile 
    530                 535                 540                 


Leu Trp Arg Leu Leu Arg Lys Leu Gln Lys Cys His Asn Glu Pro Ala 
545                 550                 555                 560 


Gln Glu Lys Met Ala Tyr Val Ala Val Ala Val Ser Pro 
                565                 570             


<210>  3900
<211>  2509
<212>  DNA
<213>  Homosapiens

<400>  3900
ttccagcgtt gcgagacggt cggttccaag tgggcctggg cgcgggggag aggcgggtct     60

gtcctcggga actgcaaggc cctgtgagcg ggaggactgg gatcccggcc gcggctgctg    120

gaagcgtcga agctcagcgg gccgcggaca tgacctgtgc ttagaactca tcctggcccg    180

cagagcctgc cgcgagtccc tggcgtcccc tgtggcgggc tcttggagcc actttcccga    240

gcggaagtca gcccgcggct cggactccgg cgggacctgc tcggaggaat ggcgccgccg    300

ggttcaagca ctgtcttcct gttggccctg acaatcatag ccagcacctg ggctctgacg    360

cccactcact acctcaccaa gcatgacgtg gagagactaa aagcctcgct ggatcgccct    420

ttcacaaatt tggaatctgc cttctactcc atcgtgggac tcagcagcct tggtgctcag    480

gtgccagatg caaagaaagc atgtacctac atcagatcta accttgatcc cagcaatgtg    540

gattccctct tctacgctgc ccaggccagc caggccctct caggatgtga gatctctatt    600

tcaaatgaga ccaaagatct gcttctggca gctgtcagtg aggactcatc tgttacccag    660

atctaccatg cagttgcagc tctaagtggc tttggccttc ccttggcatc ccaagaagca    720

ctcagtgccc ttactgctcg tctcagcaag gaggagactg tgctggcaac agtccaggct    780

ctgcagacag catcccacct gtcccagcag gctgacctga ggagcatcgt ggaggagatt    840

gaggaccttg ttgctcgcct ggatgaactc gggggcgtgt atctccagtt tgaagaagga    900

ctggaaacaa cagcgttatt tgtggctgcc acctacaagc tcatggatca tgtggggact    960

gagccatcca ttaaggagga tcaggtcatc cagctgatga acgcgatctt cagcaagaag   1020

aactttgagt ccctctccga agccttcagc gtggcctctg cagctgctgt gctctcgcat   1080

aatcgctacc acgtgccagt tgtggttgtg cctgagggct ctgcttccga cactcatgaa   1140

caggctatct tgcggttgca agtcaccaat gttctgtctc agcctctgac tcaggccact   1200

gttaaactag aacatgctaa atctgttgct tccagagcca ctgtcctcca gaagacatcc   1260

ttcacccctg taggggatgt ttttgaacta aatttcatga acgtcaaatt ttccagtggt   1320

tattatgact tccttgtcga agttgaaggt gacaaccggt atattgcaaa taccgtagag   1380

ctcagagtca agatctccac tgaagttggc atcacaaatg ttgatctttc caccgtggat   1440

aaggatcaga gcattgcacc caaaactacc cgggtgacat acccagccaa agccaagggc   1500

acattcatcg cagacagcca ccagaacttc gccttgttct tccagctggt agatgtgaac   1560

actggtgctg aactcactcc tcaccagaca tttgtccgac tccataacca gaagactggc   1620

caggaagtgg tgtttgttgc cgagccagac aacaagaacg tgtacaagtt tgaactggat   1680

acctctgaaa gaaagattga atttgactct gcctctggca cctacactct ctacttaatc   1740

attggagatg ccactttgaa gaacccaatc ctctggaatg tggctgatgt ggtcatcaag   1800

ttccctgagg aagaagctcc ctcgactgtc ttgtcccaga accttttcac tccaaaacag   1860

gaaattcagc acctgttccg cgagcctgag aagaggcccc ccaccgtggt gtccaataca   1920

ttcactgccc tgatcctctc gccgttgctt ctgctcttcg ctctgtggat ccggattggt   1980

gccaatgtct ccaacttcac ttttgctcct agcacgatta tatttcacct gggacatgct   2040

gctatgctgg gactcatgta tgtctactgg actcagctca acatgttcca gaccttgaag   2100

tacctggcca tcctgggcag tgtgacgttt ctggctggca atcggatgct ggcccagcag   2160

gcagtcaaga gaacagcaca ttagttccag aagaaagatg gaaattctga aaactgaatg   2220

tcaagaaaag gagtcaagaa caattcacag tatgagaaga aaaatggaaa aaaaaaactt   2280

tatttaaaaa agaaaaaagt ccagattgta gttatacttt tgcttgtttt tcagtttccc   2340

caacacacag cagatacctg gtgagctcag atagtctctt tctctgacac tgtgtaagaa   2400

gctgtgaata ttcctaactt acccagatgt tgcttttgaa aagttgaaat gtgtaattgt   2460

tttggaataa agagggtaac aataggaaca aaaaaaaaaa aaaaaaaaa               2509


<210>  3901
<211>  631
<212>  PRT
<213>  Homosapiens

<400>  3901

Met Ala Pro Pro Gly Ser Ser Thr Val Phe Leu Leu Ala Leu Thr Ile 
1               5                   10                  15      


Ile Ala Ser Thr Trp Ala Leu Thr Pro Thr His Tyr Leu Thr Lys His 
            20                  25                  30          


Asp Val Glu Arg Leu Lys Ala Ser Leu Asp Arg Pro Phe Thr Asn Leu 
        35                  40                  45              


Glu Ser Ala Phe Tyr Ser Ile Val Gly Leu Ser Ser Leu Gly Ala Gln 
    50                  55                  60                  


Val Pro Asp Ala Lys Lys Ala Cys Thr Tyr Ile Arg Ser Asn Leu Asp 
65                  70                  75                  80  


Pro Ser Asn Val Asp Ser Leu Phe Tyr Ala Ala Gln Ala Ser Gln Ala 
                85                  90                  95      


Leu Ser Gly Cys Glu Ile Ser Ile Ser Asn Glu Thr Lys Asp Leu Leu 
            100                 105                 110         


Leu Ala Ala Val Ser Glu Asp Ser Ser Val Thr Gln Ile Tyr His Ala 
        115                 120                 125             


Val Ala Ala Leu Ser Gly Phe Gly Leu Pro Leu Ala Ser Gln Glu Ala 
    130                 135                 140                 


Leu Ser Ala Leu Thr Ala Arg Leu Ser Lys Glu Glu Thr Val Leu Ala 
145                 150                 155                 160 


Thr Val Gln Ala Leu Gln Thr Ala Ser His Leu Ser Gln Gln Ala Asp 
                165                 170                 175     


Leu Arg Ser Ile Val Glu Glu Ile Glu Asp Leu Val Ala Arg Leu Asp 
            180                 185                 190         


Glu Leu Gly Gly Val Tyr Leu Gln Phe Glu Glu Gly Leu Glu Thr Thr 
        195                 200                 205             


Ala Leu Phe Val Ala Ala Thr Tyr Lys Leu Met Asp His Val Gly Thr 
    210                 215                 220                 


Glu Pro Ser Ile Lys Glu Asp Gln Val Ile Gln Leu Met Asn Ala Ile 
225                 230                 235                 240 


Phe Ser Lys Lys Asn Phe Glu Ser Leu Ser Glu Ala Phe Ser Val Ala 
                245                 250                 255     


Ser Ala Ala Ala Val Leu Ser His Asn Arg Tyr His Val Pro Val Val 
            260                 265                 270         


Val Val Pro Glu Gly Ser Ala Ser Asp Thr His Glu Gln Ala Ile Leu 
        275                 280                 285             


Arg Leu Gln Val Thr Asn Val Leu Ser Gln Pro Leu Thr Gln Ala Thr 
    290                 295                 300                 


Val Lys Leu Glu His Ala Lys Ser Val Ala Ser Arg Ala Thr Val Leu 
305                 310                 315                 320 


Gln Lys Thr Ser Phe Thr Pro Val Gly Asp Val Phe Glu Leu Asn Phe 
                325                 330                 335     


Met Asn Val Lys Phe Ser Ser Gly Tyr Tyr Asp Phe Leu Val Glu Val 
            340                 345                 350         


Glu Gly Asp Asn Arg Tyr Ile Ala Asn Thr Val Glu Leu Arg Val Lys 
        355                 360                 365             


Ile Ser Thr Glu Val Gly Ile Thr Asn Val Asp Leu Ser Thr Val Asp 
    370                 375                 380                 


Lys Asp Gln Ser Ile Ala Pro Lys Thr Thr Arg Val Thr Tyr Pro Ala 
385                 390                 395                 400 


Lys Ala Lys Gly Thr Phe Ile Ala Asp Ser His Gln Asn Phe Ala Leu 
                405                 410                 415     


Phe Phe Gln Leu Val Asp Val Asn Thr Gly Ala Glu Leu Thr Pro His 
            420                 425                 430         


Gln Thr Phe Val Arg Leu His Asn Gln Lys Thr Gly Gln Glu Val Val 
        435                 440                 445             


Phe Val Ala Glu Pro Asp Asn Lys Asn Val Tyr Lys Phe Glu Leu Asp 
    450                 455                 460                 


Thr Ser Glu Arg Lys Ile Glu Phe Asp Ser Ala Ser Gly Thr Tyr Thr 
465                 470                 475                 480 


Leu Tyr Leu Ile Ile Gly Asp Ala Thr Leu Lys Asn Pro Ile Leu Trp 
                485                 490                 495     


Asn Val Ala Asp Val Val Ile Lys Phe Pro Glu Glu Glu Ala Pro Ser 
            500                 505                 510         


Thr Val Leu Ser Gln Asn Leu Phe Thr Pro Lys Gln Glu Ile Gln His 
        515                 520                 525             


Leu Phe Arg Glu Pro Glu Lys Arg Pro Pro Thr Val Val Ser Asn Thr 
    530                 535                 540                 


Phe Thr Ala Leu Ile Leu Ser Pro Leu Leu Leu Leu Phe Ala Leu Trp 
545                 550                 555                 560 


Ile Arg Ile Gly Ala Asn Val Ser Asn Phe Thr Phe Ala Pro Ser Thr 
                565                 570                 575     


Ile Ile Phe His Leu Gly His Ala Ala Met Leu Gly Leu Met Tyr Val 
            580                 585                 590         


Tyr Trp Thr Gln Leu Asn Met Phe Gln Thr Leu Lys Tyr Leu Ala Ile 
        595                 600                 605             


Leu Gly Ser Val Thr Phe Leu Ala Gly Asn Arg Met Leu Ala Gln Gln 
    610                 615                 620                 


Ala Val Lys Arg Thr Ala His 
625                 630     


<210>  3902
<211>  454
<212>  DNA
<213>  Homosapiens

<400>  3902
atgccactct gggtgttctt ctttgtgatc ctcaccctca gcaacagctc ccactgctcc     60

ccacctcccc ctttgaccct caggatgcgg cggtatgcag atgccatctt caccaacagc    120

taccggaagg tgctgggcca gctgtccgcc cgcaagctgc tccaggacat catgagcagg    180

cagcagggag agagcaacca agagcgagga gcaagggcac ggcttggtcg tcaggtagac    240

agcatgtggg cagaacaaaa gcaaatggaa ttggagagca tcctggtggc cctgctgcag    300

aagcacagca ggaactccca gggatgaaga ttcctcctgt gacccgggct acctgtagcc    360

aaaatgcaac tggatccagt taatcctctc atttctgacc cactttttcc tttgaaaata    420

caataaaatt cccccatacc ggtgtgcatt taaa                                454


<210>  3903
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  3903

Met Pro Leu Trp Val Phe Phe Phe Val Ile Leu Thr Leu Ser Asn Ser 
1               5                   10                  15      


Ser His Cys Ser Pro Pro Pro Pro Leu Thr Leu Arg Met Arg Arg Tyr 
            20                  25                  30          


Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln Leu 
        35                  40                  45              


Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg Gln Gln Gly Glu 
    50                  55                  60                  


Ser Asn Gln Glu Arg Gly Ala Arg Ala Arg Leu Gly Arg Gln Val Asp 
65                  70                  75                  80  


Ser Met Trp Ala Glu Gln Lys Gln Met Glu Leu Glu Ser Ile Leu Val 
                85                  90                  95      


Ala Leu Leu Gln Lys His Ser Arg Asn Ser Gln Gly 
            100                 105             


<210>  3904
<211>  1268
<212>  DNA
<213>  Homosapiens

<400>  3904
gggaactact tccgggggag cggcgcggcg gcgcgggagt tggttctaaa gagtggtgag     60

tcagaagaga cgtcaggcag caagcgactt gggccatggc ctctgaccta gacttctcac    120

ctccggaggt gcccgagccc actttcctgg agaacctgct acggtacgga ctcttcctgg    180

gagccatctt ccagctcatc tgtgtgctgg ccatcatcgt acccattccc aagtcccacg    240

aggcggaggc tgaaccgtct gagcccagaa gtgctgaggt gacgaggaag cccaaggctg    300

ctgttccttc tgtgaacaag aggcccaaga aagagactaa gaagaagcgg tagaagagga    360

ggcctgagga gctgggcggg cagggagagg gtcttgggga cagccctcct gggaatctac    420

attgtgttcc cccgcattcc aggctcaggg tctgaggagg ctgtgacgcc ctatgaccgc    480

agagatctag acagtcgtaa cagtccccag gctccagctg ggcaatccac cacttcctct    540

tccttctgct tctgtgacgg tttagagtca agggggctga aacacactgt gagcatagac    600

tgtattaggt ttgttcagaa gccgggtcag ctcacagagt cacattttct tgcttagtca    660

tgtgtccctc cttgagttgc cccctccttg tgggtttaca ctacatttgg gagtcattgt    720

ctaatgctga caagcacacc ctctcccatt atttgtgcac tacagatctc ctcctgatca    780

gtcacctttg ttgctgctgt gtagacagag ccaggcctca cctgtttgtt taggccaaga    840

tgccatggac atgcagcgtt agtgatccca ctagctgtga cagccaggcc cagaaaatgc    900

ctggcgtgag agccagcaga cagccaggcc agggtaggca gtgcctgctt ctgctccatc    960

aggtgcaggg gatttggctg aaggcgtgca tatttcctgg gcacaaactt cctgagcctc   1020

tgaaatggga ggctcgtcaa tttcagacca acctcttttc aacccatcat agcacgttca   1080

aggtgtgcct tttacttcta cctgtacatc ccccatccct tcaattcttt cattccctga   1140

ccagtgagag ggttcctggg ggaagtatgg tgaataaact gacatgcatg cttcagaaaa   1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1260

aaaaaaaa                                                            1268


<210>  3905
<211>  85
<212>  PRT
<213>  Homosapiens

<400>  3905

Met Ala Ser Asp Leu Asp Phe Ser Pro Pro Glu Val Pro Glu Pro Thr 
1               5                   10                  15      


Phe Leu Glu Asn Leu Leu Arg Tyr Gly Leu Phe Leu Gly Ala Ile Phe 
            20                  25                  30          


Gln Leu Ile Cys Val Leu Ala Ile Ile Val Pro Ile Pro Lys Ser His 
        35                  40                  45              


Glu Ala Glu Ala Glu Pro Ser Glu Pro Arg Ser Ala Glu Val Thr Arg 
    50                  55                  60                  


Lys Pro Lys Ala Ala Val Pro Ser Val Asn Lys Arg Pro Lys Lys Glu 
65                  70                  75                  80  


Thr Lys Lys Lys Arg 
                85  


<210>  3906
<211>  1385
<212>  DNA
<213>  Homosapiens

<400>  3906
gggaactact tccgggggag cggcgcggcg gcgcgggagg atctctcacc ccgtcactca     60

gggtggcgca atcacgactc attggctcac tgcagcctag acctcccagc tggagcaatt    120

ctcctgcctc agccttctga gtagctggga ctacagttgg ttctaaagag tggtgagtca    180

gaagagacgt caggcagcaa gcgacttggg ccatggcctc tgacctagac ttctcacctc    240

cggaggtgcc cgagcccact ttcctggaga acctgctacg gtacggactc ttcctgggag    300

ccatcttcca gctcatctgt gtgctggcca tcatcgtacc cattcccaag tcccacgagg    360

cggaggctga accgtctgag cccagaagtg ctgaggtgac gaggaagccc aaggctgctg    420

ttccttctgt gaacaagagg cccaagaaag agactaagaa gaagcggtag aagaggaggc    480

ctgaggagct gggcgggcag ggagagggtc ttggggacag ccctcctggg aatctacatt    540

gtgttccccc gcattccagg ctcagggtct gaggaggctg tgacgcccta tgaccgcaga    600

gatctagaca gtcgtaacag tccccaggct ccagctgggc aatccaccac ttcctcttcc    660

ttctgcttct gtgacggttt agagtcaagg gggctgaaac acactgtgag catagactgt    720

attaggtttg ttcagaagcc gggtcagctc acagagtcac attttcttgc ttagtcatgt    780

gtccctcctt gagttgcccc ctccttgtgg gtttacacta catttgggag tcattgtcta    840

atgctgacaa gcacaccctc tcccattatt tgtgcactac agatctcctc ctgatcagtc    900

acctttgttg ctgctgtgta gacagagcca ggcctcacct gtttgtttag gccaagatgc    960

catggacatg cagcgttagt gatcccacta gctgtgacag ccaggcccag aaaatgcctg   1020

gcgtgagagc cagcagacag ccaggccagg gtaggcagtg cctgcttctg ctccatcagg   1080

tgcaggggat ttggctgaag gcgtgcatat ttcctgggca caaacttcct gagcctctga   1140

aatgggaggc tcgtcaattt cagaccaacc tcttttcaac ccatcatagc acgttcaagg   1200

tgtgcctttt acttctacct gtacatcccc catcccttca attctttcat tccctgacca   1260

gtgagagggt tcctggggga agtatggtga ataaactgac atgcatgctt cagaaaaaaa   1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1380

aaaaa                                                               1385


<210>  3907
<211>  85
<212>  PRT
<213>  Homosapiens

<400>  3907

Met Ala Ser Asp Leu Asp Phe Ser Pro Pro Glu Val Pro Glu Pro Thr 
1               5                   10                  15      


Phe Leu Glu Asn Leu Leu Arg Tyr Gly Leu Phe Leu Gly Ala Ile Phe 
            20                  25                  30          


Gln Leu Ile Cys Val Leu Ala Ile Ile Val Pro Ile Pro Lys Ser His 
        35                  40                  45              


Glu Ala Glu Ala Glu Pro Ser Glu Pro Arg Ser Ala Glu Val Thr Arg 
    50                  55                  60                  


Lys Pro Lys Ala Ala Val Pro Ser Val Asn Lys Arg Pro Lys Lys Glu 
65                  70                  75                  80  


Thr Lys Lys Lys Arg 
                85  


<210>  3908
<211>  3734
<212>  DNA
<213>  Homosapiens

<400>  3908
caaatgcgaa cttaggctgt tacacaactg ctggggtctg ttctcgccgc ccgcccggca     60

gtcaggcagc gtcgccgccg tggtagcagc ctcagccgtt tctggagtct cgggcccaca    120

gtcaccgccg cttacctgcg cctcctcgag cctccggagt ccccgtccgc ccgcacaggc    180

cggttcgccg tctgcgtctc ccccacgccg cctcgcctgc cgccgcgctc gtccctccgg    240

gccgacatga gtggggacca cctccacaac gattcccaga tcgaagcgga tttccgattg    300

aatgattctc ataaacacaa agataaacac aaagatcgag aacaccggca caaagaacac    360

aagaaggaga aggaccggga aaagtccaag catagcaaca gtgaacataa agattctgaa    420

aagaaacaca aagagaagga gaagaccaaa cacaaagatg gaagctcaga aaagcataaa    480

gacaaacata aagacagaga caaggaaaaa cgaaaagagg aaaaggttcg agcctctggg    540

gatgcaaaaa taaagaagga gaaggaaaat ggcttctcta gtccaccaca aattaaagat    600

gaacctgaag atgatggcta ttttgttcct cctaaagagg atataaagcc attaaagaga    660

cctcgagatg aggatgatgc tgattataaa cctaagaaaa ttaaaacaga agataccaag    720

aaggagaaga aaagaaaact agaagaagaa gaggatggta aattgaaaaa acccaagaat    780

aaagataaag ataaaaaagt tcctgagcca gataacaaga aaaagaagcc gaagaaagaa    840

gaggaacaga agtggaaatg gtgggaagaa gagcgctatc ctgaaggcat caagtggaaa    900

ttcctagaac ataaaggtcc agtatttgcc ccaccatatg agcctcttcc agagaatgtc    960

aagttttatt atgatggtaa agtcatgaag ctgagcccca aagcagagga agtagctacg   1020

ttctttgcaa aaatgctcga ccatgaatat actaccaagg aaatatttag gaaaaatttc   1080

tttaaagact ggagaaagga aatgactaat gaagagaaga atattatcac caacctaagc   1140

aaatgtgatt ttacccagat gagccagtat ttcaaagccc agacggaagc tcggaaacag   1200

atgagcaagg aagagaaact gaaaatcaaa gaggagaatg aaaaattact gaaagaatat   1260

ggattctgta ttatggataa ccacaaagag aggattgcta acttcaagat agagcctcct   1320

ggacttttcc gtggccgcgg caaccacccc aagatgggca tgctgaagag acgaatcatg   1380

cccgaggata taatcatcaa ctgtagcaaa gatgccaagg ttccttctcc tcctccagga   1440

cataagtgga aagaagtccg gcatgataac aaggttactt ggctggtttc ctggacagag   1500

aacatccaag gttccattaa atacatcatg cttaacccta gttcacgaat caagggtgag   1560

aaggactggc agaaatacga gactgctcgg cggctgaaaa aatgtgtgga caagatccgg   1620

aaccagtatc gagaagactg gaagtccaaa gagatgaaag tccggcagag agctgtagcc   1680

ctgtacttca tcgacaagct tgctctgaga gcaggcaatg aaaaggagga aggagaaaca   1740

gcggacactg tgggctgctg ctcacttcgt gtggagcaca tcaatctaca cccagagttg   1800

gatggtcagg aatatgtggt agagtttgac ttcctcggga aggactccat cagatactat   1860

aacaaggtcc ctgttgagaa acgagttttt aagaacctac aactatttat ggagaacaag   1920

cagcccgagg atgatctttt tgatagactc aatactggta ttctgaataa gcatcttcag   1980

gatctcatgg agggcttgac agccaaggta ttccgtacat acaatgcctc catcacgcta   2040

cagcagcagc taaaagaact gacagccccg gatgagaaca tcccagcgaa gatcctttct   2100

tataaccgtg ccaatcgagc tgttgcaatt ctttgtaacc atcagagggc accaccaaaa   2160

acttttgaga agtctatgat gaacttgcaa actaagattg atgccaagaa ggaacagcta   2220

gcagatgccc ggagagacct gaaaagtgct aaggctgatg ccaaggtcat gaaggatgca   2280

aagacgaaga aggtagtaga gtcaaagaag aaggctgttc agagactgga ggaacagttg   2340

atgaagctgg aagttcaagc cacagaccga gaggaaaata aacagattgc cctgggaacc   2400

tccaaactca attatctgga ccctaggatc acagtggctt ggtgcaagaa gtggggtgtc   2460

ccaattgaga agatttacaa caaaacccag cgggagaagt ttgcctgggc cattgacatg   2520

gctgatgaag actatgagtt ttagccagtc tcaagaggca gagttctgtg aagaggaaca   2580

gtgtggtttg ggaaagatgg ataaactgag cctcacttgc cctcgtgcct gggggagaga   2640

ggcagcaagt cttaacaaac caacatcttt gcgaaaagat aaacctggag atattataag   2700

ggagagctga gccagttgtc ctatggacaa cttatttaaa aatatttcag atatcaaaat   2760

tctagctgta tgatttgttt tgaattttgt ttttattttc aagagggcaa gtggatggga   2820

atttgtcagc gttctaccag gcaaattcac tgtttcactg aaatgtttgg attctcttag   2880

ctactgtatg caaagtccga ttatattggt gcgtttttac agttagggtt ttgcaataac   2940

ttctatattt taatagaaat aaattcctaa actcccttcc ctctctccca tttcaggaat   3000

ttaaaattaa gtagaacaaa aaacccagcg cacctgttag agtcgtcact ctctattgtc   3060

atggggatca attttcatta aacttgaagc agtcgtggct ttggcagtgt tttggttcag   3120

acacctgttc acagaaaaag catgatggga aaatatttcc tgacttgagt gttccttttt   3180

aaatgtgaat ttttatttct ttttaattat tttaaaatat ttaaaccttt ttcttgatct   3240

taaagatcgt gtagattggg gttggggagg gatgaagggc gagtgaatct aaggataatg   3300

aaataatcag tgactgaaac cattttccca tcatcctttg ttctgagcat tcgctgtacc   3360

ctttaagata tccatctttt tctttttaac cctaatcttt cacttgaaag attttattgt   3420

ataaaaagtt tcacaggtca ataaacttag aggaaaatga gtatttggtc caaaaaaagg   3480

aaaaataatc aagattttag ggcttttatt ttttcttttg taattgtgta aaaaatggaa   3540

aaaaacataa aaagcagaat tttaatgtga agacattttt tgctataatc attagtttta   3600

gaggcattgt tagtttagtg tgtgtgcaga gtccatttcc cacatctttc ctcaagtatc   3660

ttctattttt atcatgaatt cccttttaat caactgtagg ttatttaaaa taaattccta   3720

caacttaatg gaaa                                                     3734


<210>  3909
<211>  765
<212>  PRT
<213>  Homosapiens

<400>  3909

Met Ser Gly Asp His Leu His Asn Asp Ser Gln Ile Glu Ala Asp Phe 
1               5                   10                  15      


Arg Leu Asn Asp Ser His Lys His Lys Asp Lys His Lys Asp Arg Glu 
            20                  25                  30          


His Arg His Lys Glu His Lys Lys Glu Lys Asp Arg Glu Lys Ser Lys 
        35                  40                  45              


His Ser Asn Ser Glu His Lys Asp Ser Glu Lys Lys His Lys Glu Lys 
    50                  55                  60                  


Glu Lys Thr Lys His Lys Asp Gly Ser Ser Glu Lys His Lys Asp Lys 
65                  70                  75                  80  


His Lys Asp Arg Asp Lys Glu Lys Arg Lys Glu Glu Lys Val Arg Ala 
                85                  90                  95      


Ser Gly Asp Ala Lys Ile Lys Lys Glu Lys Glu Asn Gly Phe Ser Ser 
            100                 105                 110         


Pro Pro Gln Ile Lys Asp Glu Pro Glu Asp Asp Gly Tyr Phe Val Pro 
        115                 120                 125             


Pro Lys Glu Asp Ile Lys Pro Leu Lys Arg Pro Arg Asp Glu Asp Asp 
    130                 135                 140                 


Ala Asp Tyr Lys Pro Lys Lys Ile Lys Thr Glu Asp Thr Lys Lys Glu 
145                 150                 155                 160 


Lys Lys Arg Lys Leu Glu Glu Glu Glu Asp Gly Lys Leu Lys Lys Pro 
                165                 170                 175     


Lys Asn Lys Asp Lys Asp Lys Lys Val Pro Glu Pro Asp Asn Lys Lys 
            180                 185                 190         


Lys Lys Pro Lys Lys Glu Glu Glu Gln Lys Trp Lys Trp Trp Glu Glu 
        195                 200                 205             


Glu Arg Tyr Pro Glu Gly Ile Lys Trp Lys Phe Leu Glu His Lys Gly 
    210                 215                 220                 


Pro Val Phe Ala Pro Pro Tyr Glu Pro Leu Pro Glu Asn Val Lys Phe 
225                 230                 235                 240 


Tyr Tyr Asp Gly Lys Val Met Lys Leu Ser Pro Lys Ala Glu Glu Val 
                245                 250                 255     


Ala Thr Phe Phe Ala Lys Met Leu Asp His Glu Tyr Thr Thr Lys Glu 
            260                 265                 270         


Ile Phe Arg Lys Asn Phe Phe Lys Asp Trp Arg Lys Glu Met Thr Asn 
        275                 280                 285             


Glu Glu Lys Asn Ile Ile Thr Asn Leu Ser Lys Cys Asp Phe Thr Gln 
    290                 295                 300                 


Met Ser Gln Tyr Phe Lys Ala Gln Thr Glu Ala Arg Lys Gln Met Ser 
305                 310                 315                 320 


Lys Glu Glu Lys Leu Lys Ile Lys Glu Glu Asn Glu Lys Leu Leu Lys 
                325                 330                 335     


Glu Tyr Gly Phe Cys Ile Met Asp Asn His Lys Glu Arg Ile Ala Asn 
            340                 345                 350         


Phe Lys Ile Glu Pro Pro Gly Leu Phe Arg Gly Arg Gly Asn His Pro 
        355                 360                 365             


Lys Met Gly Met Leu Lys Arg Arg Ile Met Pro Glu Asp Ile Ile Ile 
    370                 375                 380                 


Asn Cys Ser Lys Asp Ala Lys Val Pro Ser Pro Pro Pro Gly His Lys 
385                 390                 395                 400 


Trp Lys Glu Val Arg His Asp Asn Lys Val Thr Trp Leu Val Ser Trp 
                405                 410                 415     


Thr Glu Asn Ile Gln Gly Ser Ile Lys Tyr Ile Met Leu Asn Pro Ser 
            420                 425                 430         


Ser Arg Ile Lys Gly Glu Lys Asp Trp Gln Lys Tyr Glu Thr Ala Arg 
        435                 440                 445             


Arg Leu Lys Lys Cys Val Asp Lys Ile Arg Asn Gln Tyr Arg Glu Asp 
    450                 455                 460                 


Trp Lys Ser Lys Glu Met Lys Val Arg Gln Arg Ala Val Ala Leu Tyr 
465                 470                 475                 480 


Phe Ile Asp Lys Leu Ala Leu Arg Ala Gly Asn Glu Lys Glu Glu Gly 
                485                 490                 495     


Glu Thr Ala Asp Thr Val Gly Cys Cys Ser Leu Arg Val Glu His Ile 
            500                 505                 510         


Asn Leu His Pro Glu Leu Asp Gly Gln Glu Tyr Val Val Glu Phe Asp 
        515                 520                 525             


Phe Leu Gly Lys Asp Ser Ile Arg Tyr Tyr Asn Lys Val Pro Val Glu 
    530                 535                 540                 


Lys Arg Val Phe Lys Asn Leu Gln Leu Phe Met Glu Asn Lys Gln Pro 
545                 550                 555                 560 


Glu Asp Asp Leu Phe Asp Arg Leu Asn Thr Gly Ile Leu Asn Lys His 
                565                 570                 575     


Leu Gln Asp Leu Met Glu Gly Leu Thr Ala Lys Val Phe Arg Thr Tyr 
            580                 585                 590         


Asn Ala Ser Ile Thr Leu Gln Gln Gln Leu Lys Glu Leu Thr Ala Pro 
        595                 600                 605             


Asp Glu Asn Ile Pro Ala Lys Ile Leu Ser Tyr Asn Arg Ala Asn Arg 
    610                 615                 620                 


Ala Val Ala Ile Leu Cys Asn His Gln Arg Ala Pro Pro Lys Thr Phe 
625                 630                 635                 640 


Glu Lys Ser Met Met Asn Leu Gln Thr Lys Ile Asp Ala Lys Lys Glu 
                645                 650                 655     


Gln Leu Ala Asp Ala Arg Arg Asp Leu Lys Ser Ala Lys Ala Asp Ala 
            660                 665                 670         


Lys Val Met Lys Asp Ala Lys Thr Lys Lys Val Val Glu Ser Lys Lys 
        675                 680                 685             


Lys Ala Val Gln Arg Leu Glu Glu Gln Leu Met Lys Leu Glu Val Gln 
    690                 695                 700                 


Ala Thr Asp Arg Glu Glu Asn Lys Gln Ile Ala Leu Gly Thr Ser Lys 
705                 710                 715                 720 


Leu Asn Tyr Leu Asp Pro Arg Ile Thr Val Ala Trp Cys Lys Lys Trp 
                725                 730                 735     


Gly Val Pro Ile Glu Lys Ile Tyr Asn Lys Thr Gln Arg Glu Lys Phe 
            740                 745                 750         


Ala Trp Ala Ile Asp Met Ala Asp Glu Asp Tyr Glu Phe 
        755                 760                 765 


<210>  3910
<211>  5205
<212>  DNA
<213>  Homosapiens

<400>  3910
gagccgccgc cgggtcccgc tcgtctgccg cctcagcctc agccccaacc tcagccgccg     60

ccgttgcgct tgctcccggg cggtcctggc ctgtgccgcc gccgccccca gcgtcggagc    120

catggcgggc gccgcgtccc cttgcgccaa cggctgcggg cccggcgcgc cctcggacgc    180

cgaggtgctg cacctctgcc gcagcctcga ggtgggcacc gtcatgactt tgttctactc    240

caagaagtcg cagcgacccg agcggaagac cttccaggtc aagctggaga cgcgccagat    300

cacgtggagc cggggcgccg acaagatcga gggggccatt gacattcgtg aaattaagga    360

gatccgccca gggaagacct cacgggactt tgatcgctat caagaggacc cagctttccg    420

gccggaccag tcacattgct ttgtcattct ctatggaatg gaatttcgcc tgaaaacgct    480

gagcctgcaa gccacatctg aggatgaagt gaacatgtgg atcaagggct taacttggct    540

gatggaggat acattgcagg cacccacacc cctgcagatt gagaggtggc tccggaagca    600

gttttactca gtggatcgga atcgtgagga tcgtatatca gccaaggacc tgaagaacat    660

gctgtcccag gtcaactacc gggtccccaa catgcgcttc ctccgagagc ggctgacgga    720

cctggagcag cgcagcgggg acatcaccta cgggcagttt gctcagctgt accgcagcct    780

catgtacagc gcccagaaga cgatggacct ccccttcttg gaagccagta ctctgagggc    840

tggggagcgg ccggagcttt gccgagtgtc ccttcctgag ttccagcagt tccttcttga    900

ctaccagggg gagctgtggg ctgttgatcg cctccaggtg caggagttca tgctcagctt    960

cctccgagac cccttacgag agatcgagga gccatacttc ttcctggatg agtttgtcac   1020

cttcctgttc tccaaagaga acagtgtgtg gaactcgcag ctggatgcag tatgcccgga   1080

caccatgaac aaccctcttt cccactactg gatctcctcc tcgcacaaca cgtacctgac   1140

cggggaccag ttctccagtg agtcctcctt ggaagcctat gctcgctgcc tgcggatggg   1200

ctgtcgctgc attgagttgg actgctggga cggcccggat gggatgccag ttatttacca   1260

tgggcacacc cttaccacca agatcaagtt ctcagatgtc ctgcacacca tcaaggagca   1320

tgcctttgtg gcctcagagt acccagtcat cctgtccatt gaggaccact gcagcattgc   1380

ccagcagaga aacatggccc aatacttcaa gaaggtgctg ggggacacac tcctcaccaa   1440

gcccgtggag atctctgccg acgggctccc ctcacccaac cagcttaaga ggaagatcct   1500

catcaagcac aagaagctgg ctgagggcag tgcctacgag gaggtgccta catccatgat   1560

gtactctgag aacgacatca gcaactctat caagaatggc atcctctacc tggaggaccc   1620

tgtgaaccac gaatggtatc cccactactt tgttctgacc agcagcaaga tctactactc   1680

tgaggagacc agcagtgacc agggcaacga ggatgaggag gagcccaagg aggtcagcag   1740

cagcacagag ctgcactcca atgagaagtg gttccatggg aagctagggg cagggcgtga   1800

cgggcgtcac atcgctgagc gcctgcttac tgagtactgc atcgagaccg gagcccctga   1860

cggctccttc ctcgtgcgag agagtgagac cttcgtgggc gactacacgc tctctttctg   1920

gcggaacggg aaagtccagc actgccgtat ccactcccgg caagatgctg ggacccccaa   1980

gttcttcttg acagacaacc tcgtctttga ctccctctat gacctcatca cgcactacca   2040

gcaggtgccc ctgcgctgta atgagtttga gatgcgactt tcagagcctg tcccacagac   2100

caacgcccac gagagcaaag agtggtacca cgcgagcctg accagagcac aggctgagca   2160

catgctaatg cgcgtccctc gtgatggggc cttcctggtg cggaagcgga atgaacccaa   2220

ctcatatgcc atctctttcc gggctgaggg caagatcaag cattgccgtg tccagcaaga   2280

gggccagaca gtgatgctag ggaactcgga gttcgacagc cttgttgacc tcatcagcta   2340

ctatgagaaa cacccgctat accgcaagat gaagctgcgc tatcccatca acgaggaggc   2400

actggagaag attggcacag ctgagcctga ctacggggcc ctgtatgagg gacgcaaccc   2460

tggcttctat gtagaggcaa accctatgcc aactttcaag tgtgcagtca aagccctctt   2520

tgactacaag gcccagaggg aggacgagct gaccttcatc aagagcgcca tcatccagaa   2580

tgtggagaag caagagggag gctggtggcg aggggactac ggagggaaga agcagctgtg   2640

gttcccatca aactacgtgg aagagatggt caaccccgtg gccctggagc cggagaggga   2700

gcacttggac gagaacagcc ccctagggga cttgctgcgg ggggtcttgg atgtgccggc   2760

ttgtcagatt gccatccgtc ctgagggcaa gaacaaccgg ctcttcgtct tctccatcag   2820

catggcgtcg gtggcccact ggtccctgga tgttgctgcc gactcacagg aggagctgca   2880

ggactgggtg aaaaagatcc gtgaagtggc ccagacagca gacgccaggc tcactgaagg   2940

gaagataatg gaacggagga agaagattgc cctggagctc tctgaacttg tcgtctactg   3000

ccggcctgtt ccctttgatg aagagaagat tggcacagaa cgtgcttgct accgggacat   3060

gtcatccttc ccggaaacca aggctgagaa atacgtgaac aaggccaaag gcaagaagtt   3120

ccttcagtac aatcgactgc agctctcccg catctacccc aagggccagc gactggattc   3180

ctccaactac gatcctttgc ccatgtggat ctgtggcagt cagcttgtgg ccctcaactt   3240

ccagacccct gacaagccta tgcagatgaa ccaggccctc ttcatgacgg gcaggcactg   3300

tggctacgtg ctgcagccaa gcaccatgcg ggatgaggcc ttcgacccct ttgacaagag   3360

cagcctccgc gggctggagc catgtgccat ctctattgag gtgctggggg cccgacatct   3420

gccaaagaat ggccgaggca ttgtgtgtcc ttttgtggag attgaggtgg ctggagctga   3480

gtatgacagc accaagcaga agacagagtt tgtggtggac aatggactca accctgtatg   3540

gccagccaag cccttccact tccagatcag taaccctgaa tttgcctttc tgcgcttcgt   3600

ggtgtatgag gaagacatgt ttagtgacca gaatttcctg gctcaggcta ctttcccagt   3660

aaaaggcctg aagacaggat acagagcagt gcctttgaag aacaactaca gtgaggacct   3720

ggagttggcc tccctgctga tcaagattga cattttccct gccaagcagg agaatggtga   3780

cctcagtccc ttcagtggta cgtccctgcg ggagcggggc tcagatgcct caggccagct   3840

gtttcatggc cgagcccggg aaggctcctt tgaatcccgc taccagcagc cgtttgagga   3900

cttccgcatc tcccaggagc atctcgcaga ccattttgac agtcgagaac gaagggcccc   3960

aagaaggact cgggtcaatg gagacaaccg cctctagttg taccccagcc tcgttggaga   4020

gcagcaggtg ctgtgcgcct tgtagaatgc cgcgaactgg gttctttgga agcagccccc   4080

tgtggcggcc ttccgggtct cgcagcctga agcctggatt ccagcagtga atgctagaca   4140

gaaaccaagc cattaatgag atgttattac tgttttgggc ctccatgccc cagctctgga   4200

tgaaggcaaa aactgtactg tgtttcgcat taagcacaca catctggccc tgacttctgg   4260

agatggatcc ttccatcttg tggggccagg accatggccg aagccccttg gagagagagg   4320

ctgcctcagc cagtggcaca ggagactcca aggagctact gacattccta agagtggagg   4380

aggaggagga gccttgctgg gccagggaaa caaagtttac attgtcctgt agctttaaaa   4440

ccacagctgg gcagggtgag aagctagatg cccctgcagt ttggccctgg agccagggca   4500

gaggaatgta gggcctgcat ggagaagggt tctgccctgc ctgaggagga ggacacagca   4560

caagggcaca ttgcccatgg ctgggaacat gacccagcct gaaagataca ggggatcatg   4620

ttaaaaatag cagtattatt tttcgtctca atggtattgt aactaagtta tttactcctc   4680

ctgctcctca cccctgtagg gaaaccttgg agaggagagt ggcaggtggg ctgcctgctg   4740

tgttaagagg acttagtttg tgatgtaagg cactgtcagg aatggggggc gggccagggt   4800

gggaagagaa gaaatagcag agcctatttt ggtgaggttt tttgttttta agtcaaagaa   4860

gactcagtat gctttccctg aggaatgaaa aagggattga ggagttgcct gactcctggg   4920

tgggtggggt acaggcagtt aggtgctgaa tgaagctgcc atccttgctg cagcttctaa   4980

ctggtaaaaa gatccaggga tggagatggg aaggttagaa aggcagccct cacctctgag   5040

gacagaggcc ggggtccagg cccgtgggcg caaaggtgcc tcatagcata gccagcattc   5100

agcacacaca aacctactgc ccacatttgg gctcagggtt ggccatttgc tagttctgct   5160

gccctcttaa gatctgactg ccaaataaat catcctcatg tcctt                   5205


<210>  3911
<211>  1291
<212>  PRT
<213>  Homosapiens

<400>  3911

Met Ala Gly Ala Ala Ser Pro Cys Ala Asn Gly Cys Gly Pro Gly Ala 
1               5                   10                  15      


Pro Ser Asp Ala Glu Val Leu His Leu Cys Arg Ser Leu Glu Val Gly 
            20                  25                  30          


Thr Val Met Thr Leu Phe Tyr Ser Lys Lys Ser Gln Arg Pro Glu Arg 
        35                  40                  45              


Lys Thr Phe Gln Val Lys Leu Glu Thr Arg Gln Ile Thr Trp Ser Arg 
    50                  55                  60                  


Gly Ala Asp Lys Ile Glu Gly Ala Ile Asp Ile Arg Glu Ile Lys Glu 
65                  70                  75                  80  


Ile Arg Pro Gly Lys Thr Ser Arg Asp Phe Asp Arg Tyr Gln Glu Asp 
                85                  90                  95      


Pro Ala Phe Arg Pro Asp Gln Ser His Cys Phe Val Ile Leu Tyr Gly 
            100                 105                 110         


Met Glu Phe Arg Leu Lys Thr Leu Ser Leu Gln Ala Thr Ser Glu Asp 
        115                 120                 125             


Glu Val Asn Met Trp Ile Lys Gly Leu Thr Trp Leu Met Glu Asp Thr 
    130                 135                 140                 


Leu Gln Ala Pro Thr Pro Leu Gln Ile Glu Arg Trp Leu Arg Lys Gln 
145                 150                 155                 160 


Phe Tyr Ser Val Asp Arg Asn Arg Glu Asp Arg Ile Ser Ala Lys Asp 
                165                 170                 175     


Leu Lys Asn Met Leu Ser Gln Val Asn Tyr Arg Val Pro Asn Met Arg 
            180                 185                 190         


Phe Leu Arg Glu Arg Leu Thr Asp Leu Glu Gln Arg Ser Gly Asp Ile 
        195                 200                 205             


Thr Tyr Gly Gln Phe Ala Gln Leu Tyr Arg Ser Leu Met Tyr Ser Ala 
    210                 215                 220                 


Gln Lys Thr Met Asp Leu Pro Phe Leu Glu Ala Ser Thr Leu Arg Ala 
225                 230                 235                 240 


Gly Glu Arg Pro Glu Leu Cys Arg Val Ser Leu Pro Glu Phe Gln Gln 
                245                 250                 255     


Phe Leu Leu Asp Tyr Gln Gly Glu Leu Trp Ala Val Asp Arg Leu Gln 
            260                 265                 270         


Val Gln Glu Phe Met Leu Ser Phe Leu Arg Asp Pro Leu Arg Glu Ile 
        275                 280                 285             


Glu Glu Pro Tyr Phe Phe Leu Asp Glu Phe Val Thr Phe Leu Phe Ser 
    290                 295                 300                 


Lys Glu Asn Ser Val Trp Asn Ser Gln Leu Asp Ala Val Cys Pro Asp 
305                 310                 315                 320 


Thr Met Asn Asn Pro Leu Ser His Tyr Trp Ile Ser Ser Ser His Asn 
                325                 330                 335     


Thr Tyr Leu Thr Gly Asp Gln Phe Ser Ser Glu Ser Ser Leu Glu Ala 
            340                 345                 350         


Tyr Ala Arg Cys Leu Arg Met Gly Cys Arg Cys Ile Glu Leu Asp Cys 
        355                 360                 365             


Trp Asp Gly Pro Asp Gly Met Pro Val Ile Tyr His Gly His Thr Leu 
    370                 375                 380                 


Thr Thr Lys Ile Lys Phe Ser Asp Val Leu His Thr Ile Lys Glu His 
385                 390                 395                 400 


Ala Phe Val Ala Ser Glu Tyr Pro Val Ile Leu Ser Ile Glu Asp His 
                405                 410                 415     


Cys Ser Ile Ala Gln Gln Arg Asn Met Ala Gln Tyr Phe Lys Lys Val 
            420                 425                 430         


Leu Gly Asp Thr Leu Leu Thr Lys Pro Val Glu Ile Ser Ala Asp Gly 
        435                 440                 445             


Leu Pro Ser Pro Asn Gln Leu Lys Arg Lys Ile Leu Ile Lys His Lys 
    450                 455                 460                 


Lys Leu Ala Glu Gly Ser Ala Tyr Glu Glu Val Pro Thr Ser Met Met 
465                 470                 475                 480 


Tyr Ser Glu Asn Asp Ile Ser Asn Ser Ile Lys Asn Gly Ile Leu Tyr 
                485                 490                 495     


Leu Glu Asp Pro Val Asn His Glu Trp Tyr Pro His Tyr Phe Val Leu 
            500                 505                 510         


Thr Ser Ser Lys Ile Tyr Tyr Ser Glu Glu Thr Ser Ser Asp Gln Gly 
        515                 520                 525             


Asn Glu Asp Glu Glu Glu Pro Lys Glu Val Ser Ser Ser Thr Glu Leu 
    530                 535                 540                 


His Ser Asn Glu Lys Trp Phe His Gly Lys Leu Gly Ala Gly Arg Asp 
545                 550                 555                 560 


Gly Arg His Ile Ala Glu Arg Leu Leu Thr Glu Tyr Cys Ile Glu Thr 
                565                 570                 575     


Gly Ala Pro Asp Gly Ser Phe Leu Val Arg Glu Ser Glu Thr Phe Val 
            580                 585                 590         


Gly Asp Tyr Thr Leu Ser Phe Trp Arg Asn Gly Lys Val Gln His Cys 
        595                 600                 605             


Arg Ile His Ser Arg Gln Asp Ala Gly Thr Pro Lys Phe Phe Leu Thr 
    610                 615                 620                 


Asp Asn Leu Val Phe Asp Ser Leu Tyr Asp Leu Ile Thr His Tyr Gln 
625                 630                 635                 640 


Gln Val Pro Leu Arg Cys Asn Glu Phe Glu Met Arg Leu Ser Glu Pro 
                645                 650                 655     


Val Pro Gln Thr Asn Ala His Glu Ser Lys Glu Trp Tyr His Ala Ser 
            660                 665                 670         


Leu Thr Arg Ala Gln Ala Glu His Met Leu Met Arg Val Pro Arg Asp 
        675                 680                 685             


Gly Ala Phe Leu Val Arg Lys Arg Asn Glu Pro Asn Ser Tyr Ala Ile 
    690                 695                 700                 


Ser Phe Arg Ala Glu Gly Lys Ile Lys His Cys Arg Val Gln Gln Glu 
705                 710                 715                 720 


Gly Gln Thr Val Met Leu Gly Asn Ser Glu Phe Asp Ser Leu Val Asp 
                725                 730                 735     


Leu Ile Ser Tyr Tyr Glu Lys His Pro Leu Tyr Arg Lys Met Lys Leu 
            740                 745                 750         


Arg Tyr Pro Ile Asn Glu Glu Ala Leu Glu Lys Ile Gly Thr Ala Glu 
        755                 760                 765             


Pro Asp Tyr Gly Ala Leu Tyr Glu Gly Arg Asn Pro Gly Phe Tyr Val 
    770                 775                 780                 


Glu Ala Asn Pro Met Pro Thr Phe Lys Cys Ala Val Lys Ala Leu Phe 
785                 790                 795                 800 


Asp Tyr Lys Ala Gln Arg Glu Asp Glu Leu Thr Phe Ile Lys Ser Ala 
                805                 810                 815     


Ile Ile Gln Asn Val Glu Lys Gln Glu Gly Gly Trp Trp Arg Gly Asp 
            820                 825                 830         


Tyr Gly Gly Lys Lys Gln Leu Trp Phe Pro Ser Asn Tyr Val Glu Glu 
        835                 840                 845             


Met Val Asn Pro Val Ala Leu Glu Pro Glu Arg Glu His Leu Asp Glu 
    850                 855                 860                 


Asn Ser Pro Leu Gly Asp Leu Leu Arg Gly Val Leu Asp Val Pro Ala 
865                 870                 875                 880 


Cys Gln Ile Ala Ile Arg Pro Glu Gly Lys Asn Asn Arg Leu Phe Val 
                885                 890                 895     


Phe Ser Ile Ser Met Ala Ser Val Ala His Trp Ser Leu Asp Val Ala 
            900                 905                 910         


Ala Asp Ser Gln Glu Glu Leu Gln Asp Trp Val Lys Lys Ile Arg Glu 
        915                 920                 925             


Val Ala Gln Thr Ala Asp Ala Arg Leu Thr Glu Gly Lys Ile Met Glu 
    930                 935                 940                 


Arg Arg Lys Lys Ile Ala Leu Glu Leu Ser Glu Leu Val Val Tyr Cys 
945                 950                 955                 960 


Arg Pro Val Pro Phe Asp Glu Glu Lys Ile Gly Thr Glu Arg Ala Cys 
                965                 970                 975     


Tyr Arg Asp Met Ser Ser Phe Pro Glu Thr Lys Ala Glu Lys Tyr Val 
            980                 985                 990         


Asn Lys Ala Lys Gly Lys Lys Phe  Leu Gln Tyr Asn Arg  Leu Gln Leu 
        995                 1000                 1005             


Ser Arg  Ile Tyr Pro Lys Gly  Gln Arg Leu Asp Ser  Ser Asn Tyr 
    1010                 1015                 1020             


Asp Pro  Leu Pro Met Trp Ile  Cys Gly Ser Gln Leu  Val Ala Leu 
    1025                 1030                 1035             


Asn Phe  Gln Thr Pro Asp Lys  Pro Met Gln Met Asn  Gln Ala Leu 
    1040                 1045                 1050             


Phe Met  Thr Gly Arg His Cys  Gly Tyr Val Leu Gln  Pro Ser Thr 
    1055                 1060                 1065             


Met Arg  Asp Glu Ala Phe Asp  Pro Phe Asp Lys Ser  Ser Leu Arg 
    1070                 1075                 1080             


Gly Leu  Glu Pro Cys Ala Ile  Ser Ile Glu Val Leu  Gly Ala Arg 
    1085                 1090                 1095             


His Leu  Pro Lys Asn Gly Arg  Gly Ile Val Cys Pro  Phe Val Glu 
    1100                 1105                 1110             


Ile Glu  Val Ala Gly Ala Glu  Tyr Asp Ser Thr Lys  Gln Lys Thr 
    1115                 1120                 1125             


Glu Phe  Val Val Asp Asn Gly  Leu Asn Pro Val Trp  Pro Ala Lys 
    1130                 1135                 1140             


Pro Phe  His Phe Gln Ile Ser  Asn Pro Glu Phe Ala  Phe Leu Arg 
    1145                 1150                 1155             


Phe Val  Val Tyr Glu Glu Asp  Met Phe Ser Asp Gln  Asn Phe Leu 
    1160                 1165                 1170             


Ala Gln  Ala Thr Phe Pro Val  Lys Gly Leu Lys Thr  Gly Tyr Arg 
    1175                 1180                 1185             


Ala Val  Pro Leu Lys Asn Asn  Tyr Ser Glu Asp Leu  Glu Leu Ala 
    1190                 1195                 1200             


Ser Leu  Leu Ile Lys Ile Asp  Ile Phe Pro Ala Lys  Gln Glu Asn 
    1205                 1210                 1215             


Gly Asp  Leu Ser Pro Phe Ser  Gly Thr Ser Leu Arg  Glu Arg Gly 
    1220                 1225                 1230             


Ser Asp  Ala Ser Gly Gln Leu  Phe His Gly Arg Ala  Arg Glu Gly 
    1235                 1240                 1245             


Ser Phe  Glu Ser Arg Tyr Gln  Gln Pro Phe Glu Asp  Phe Arg Ile 
    1250                 1255                 1260             


Ser Gln  Glu His Leu Ala Asp  His Phe Asp Ser Arg  Glu Arg Arg 
    1265                 1270                 1275             


Ala Pro  Arg Arg Thr Arg Val  Asn Gly Asp Asn Arg  Leu 
    1280                 1285                 1290     


<210>  3912
<211>  5202
<212>  DNA
<213>  Homosapiens

<400>  3912
gagccgccgc cgggtcccgc tcgtctgccg cctcagcctc agccccaacc tcagccgccg     60

ccgttgcgct tgctcccggg cggtcctggc ctgtgccgcc gccgccccca gcgtcggagc    120

catggcgggc gccgcgtccc cttgcgccaa cggctgcggg cccggcgcgc cctcggacgc    180

cgaggtgctg cacctctgcc gcagcctcga ggtgggcacc gtcatgactt tgttctactc    240

caagaagtcg cagcgacccg agcggaagac cttccaggtc aagctggaga cgcgccagat    300

cacgtggagc cggggcgccg acaagatcga gggggccatt gacattcgtg aaattaagga    360

gatccgccca gggaagacct cacgggactt tgatcgctat caagaggacc cagctttccg    420

gccggaccag tcacattgct ttgtcattct ctatggaatg gaatttcgcc tgaaaacgct    480

gagcctgcaa gccacatctg aggatgaagt gaacatgtgg atcaagggct taacttggct    540

gatggaggat acattgcagg cacccacacc cctgcagatt gagaggtggc tccggaagca    600

gttttactca gtggatcgga atcgtgagga tcgtatatca gccaaggacc tgaagaacat    660

gctgtcccag gtcaactacc gggtccccaa catgcgcttc ctccgagagc ggctgacgga    720

cctggagcag cgcagcgggg acatcaccta cgggcagttt gctcagctgt accgcagcct    780

catgtacagc gcccagaaga cgatggacct ccccttcttg gaagccagta ctctgagggc    840

tggggagcgg ccggagcttt gccgagtgtc ccttcctgag ttccagcagt tccttcttga    900

ctaccagggg gagctgtggg ctgttgatcg cctccaggtg caggagttca tgctcagctt    960

cctccgagac cccttacgag agatcgagga gccatacttc ttcctggatg agtttgtcac   1020

cttcctgttc tccaaagaga acagtgtgtg gaactcgcag ctggatgcag tatgcccgga   1080

caccatgaac aaccctcttt cccactactg gatctcctcc tcgcacaaca cgtacctgac   1140

cggggaccag ttctccagtg agtcctcctt ggaagcctat gctcgctgcc tgcggatggg   1200

ctgtcgctgc attgagttgg actgctggga cggcccggat gggatgccag ttatttacca   1260

tgggcacacc cttaccacca agatcaagtt ctcagatgtc ctgcacacca tcaaggagca   1320

tgcctttgtg gcctcagagt acccagtcat cctgtccatt gaggaccact gcagcattgc   1380

ccagcagaga aacatggccc aatacttcaa gaaggtgctg ggggacacac tcctcaccaa   1440

gcccgtggag atctctgccg acgggctccc ctcacccaac cagcttaaga ggaagatcct   1500

catcaagcac aagaagctgg ctgagggcag tgcctacgag gaggtgccta catccatgat   1560

gtactctgag aacgacatca gcaactctat caagaatggc atcctctacc tggaggaccc   1620

tgtgaaccac gaatggtatc cccactactt tgttctgacc agcagcaaga tctactactc   1680

tgaggagacc agcagtgacc agggcaacga ggatgaggag gagcccaagg aggtcagcag   1740

cagcacagag ctgcactcca atgagaagtg gttccatggg aagctagggg cagggcgtga   1800

cgggcgtcac atcgctgagc gcctgcttac tgagtactgc atcgagaccg gagcccctga   1860

cggctccttc ctcgtgcgag agagtgagac cttcgtgggc gactacacgc tctctttctg   1920

gcggaacggg aaagtccagc actgccgtat ccactcccgg caagatgctg ggacccccaa   1980

gttcttcttg acagacaacc tcgtctttga ctccctctat gacctcatca cgcactacca   2040

gcaggtgccc ctgcgctgta atgagtttga gatgcgactt tcagagcctg tcccacagac   2100

caacgcccac gagagcaaag agtggtacca cgcgagcctg accagagcac aggctgagca   2160

catgctaatg cgcgtccctc gtgatggggc cttcctggtg cggaagcgga atgaacccaa   2220

ctcatatgcc atctctttcc gggctgaggg caagatcaag cattgccgtg tccagcaaga   2280

gggccagaca gtgatgctag ggaactcgga gttcgacagc cttgttgacc tcatcagcta   2340

ctatgagaaa cacccgctat accgcaagat gaagctgcgc tatcccatca acgaggaggc   2400

actggagaag attggcacag ctgagcctga ctacggggcc ctgtatgagg gacgcaaccc   2460

tggcttctat gtagaggcaa accctatgcc aactttcaag tgtgcagtca aagccctctt   2520

tgactacaag gcccagaggg aggacgagct gaccttcatc aagagcgcca tcatccagaa   2580

tgtggagaag caagagggag gctggtggcg aggggactac ggagggaaga agcagctgtg   2640

gttcccatca aactacgtgg aagagatggt caaccccgtg gccctggagc cggagaggga   2700

gcacttggac gagaacagcc ccctagggga cttgctgcgg ggggtcttgg atgtgccggc   2760

ttgtcagatt gccatccgtc ctgagggcaa gaacaaccgg ctcttcgtct tctccatcag   2820

catggcgtcg gtggcccact ggtccctgga tgttgctgcc gactcacagg aggagctgca   2880

ggactgggtg aaaaagatcc gtgaagtggc ccagacagca gacgccaggc tcactgaagg   2940

gaagataatg gaacggagga agaagattgc cctggagctc tctgaacttg tcgtctactg   3000

ccggcctgtt ccctttgatg aagagaagat tggcacagaa cgtgcttgct accgggacat   3060

gtcatccttc ccggaaacca aggctgagaa atacgtgaac aaggccaaag gcaagaagtt   3120

ccttcagtac aatcgactgc agctctcccg catctacccc aagggccagc gactggattc   3180

ctccaactac gatcctttgc ccatgtggat ctgtggcagt cagcttgtgg ccctcaactt   3240

ccagacccct gacaagccta tgcagatgaa ccaggccctc ttcatgacgg gcaggcactg   3300

tggctacgtg ctgcagccaa gcaccatgcg ggatgaggcc ttcgacccct ttgacaagag   3360

cagcctccgc gggctggagc catgtgccat ctctattgag gtgctggggg cccgacatct   3420

gccaaagaat ggccgaggca ttgtgtgtcc ttttgtggag attgaggtgg ctggagctga   3480

gtatgacagc accaagcaga agacagagtt tgtggtggac aatggactca accctgtatg   3540

gccagccaag cccttccact tccagatcag taaccctgaa tttgcctttc tgcgcttcgt   3600

ggtgtatgag gaagacatgt ttagtgacca gaatttcctg gctcaggcta ctttcccagt   3660

aaaaggcctg aagacaggat acagagcagt gcctttgaag aacaactaca gtgaggacct   3720

ggagttggcc tccctgctga tcaagattga cattttccct gccaaggaga atggtgacct   3780

cagtcccttc agtggtacgt ccctgcggga gcggggctca gatgcctcag gccagctgtt   3840

tcatggccga gcccgggaag gctcctttga atcccgctac cagcagccgt ttgaggactt   3900

ccgcatctcc caggagcatc tcgcagacca ttttgacagt cgagaacgaa gggccccaag   3960

aaggactcgg gtcaatggag acaaccgcct ctagttgtac cccagcctcg ttggagagca   4020

gcaggtgctg tgcgccttgt agaatgccgc gaactgggtt ctttggaagc agccccctgt   4080

ggcggccttc cgggtctcgc agcctgaagc ctggattcca gcagtgaatg ctagacagaa   4140

accaagccat taatgagatg ttattactgt tttgggcctc catgccccag ctctggatga   4200

aggcaaaaac tgtactgtgt ttcgcattaa gcacacacat ctggccctga cttctggaga   4260

tggatccttc catcttgtgg ggccaggacc atggccgaag ccccttggag agagaggctg   4320

cctcagccag tggcacagga gactccaagg agctactgac attcctaaga gtggaggagg   4380

aggaggagcc ttgctgggcc agggaaacaa agtttacatt gtcctgtagc tttaaaacca   4440

cagctgggca gggtgagaag ctagatgccc ctgcagtttg gccctggagc cagggcagag   4500

gaatgtaggg cctgcatgga gaagggttct gccctgcctg aggaggagga cacagcacaa   4560

gggcacattg cccatggctg ggaacatgac ccagcctgaa agatacaggg gatcatgtta   4620

aaaatagcag tattattttt cgtctcaatg gtattgtaac taagttattt actcctcctg   4680

ctcctcaccc ctgtagggaa accttggaga ggagagtggc aggtgggctg cctgctgtgt   4740

taagaggact tagtttgtga tgtaaggcac tgtcaggaat ggggggcggg ccagggtggg   4800

aagagaagaa atagcagagc ctattttggt gaggtttttt gtttttaagt caaagaagac   4860

tcagtatgct ttccctgagg aatgaaaaag ggattgagga gttgcctgac tcctgggtgg   4920

gtggggtaca ggcagttagg tgctgaatga agctgccatc cttgctgcag cttctaactg   4980

gtaaaaagat ccagggatgg agatgggaag gttagaaagg cagccctcac ctctgaggac   5040

agaggccggg gtccaggccc gtgggcgcaa aggtgcctca tagcatagcc agcattcagc   5100

acacacaaac ctactgccca catttgggct cagggttggc catttgctag ttctgctgcc   5160

ctcttaagat ctgactgcca aataaatcat cctcatgtcc tt                      5202


<210>  3913
<211>  1290
<212>  PRT
<213>  Homosapiens

<400>  3913

Met Ala Gly Ala Ala Ser Pro Cys Ala Asn Gly Cys Gly Pro Gly Ala 
1               5                   10                  15      


Pro Ser Asp Ala Glu Val Leu His Leu Cys Arg Ser Leu Glu Val Gly 
            20                  25                  30          


Thr Val Met Thr Leu Phe Tyr Ser Lys Lys Ser Gln Arg Pro Glu Arg 
        35                  40                  45              


Lys Thr Phe Gln Val Lys Leu Glu Thr Arg Gln Ile Thr Trp Ser Arg 
    50                  55                  60                  


Gly Ala Asp Lys Ile Glu Gly Ala Ile Asp Ile Arg Glu Ile Lys Glu 
65                  70                  75                  80  


Ile Arg Pro Gly Lys Thr Ser Arg Asp Phe Asp Arg Tyr Gln Glu Asp 
                85                  90                  95      


Pro Ala Phe Arg Pro Asp Gln Ser His Cys Phe Val Ile Leu Tyr Gly 
            100                 105                 110         


Met Glu Phe Arg Leu Lys Thr Leu Ser Leu Gln Ala Thr Ser Glu Asp 
        115                 120                 125             


Glu Val Asn Met Trp Ile Lys Gly Leu Thr Trp Leu Met Glu Asp Thr 
    130                 135                 140                 


Leu Gln Ala Pro Thr Pro Leu Gln Ile Glu Arg Trp Leu Arg Lys Gln 
145                 150                 155                 160 


Phe Tyr Ser Val Asp Arg Asn Arg Glu Asp Arg Ile Ser Ala Lys Asp 
                165                 170                 175     


Leu Lys Asn Met Leu Ser Gln Val Asn Tyr Arg Val Pro Asn Met Arg 
            180                 185                 190         


Phe Leu Arg Glu Arg Leu Thr Asp Leu Glu Gln Arg Ser Gly Asp Ile 
        195                 200                 205             


Thr Tyr Gly Gln Phe Ala Gln Leu Tyr Arg Ser Leu Met Tyr Ser Ala 
    210                 215                 220                 


Gln Lys Thr Met Asp Leu Pro Phe Leu Glu Ala Ser Thr Leu Arg Ala 
225                 230                 235                 240 


Gly Glu Arg Pro Glu Leu Cys Arg Val Ser Leu Pro Glu Phe Gln Gln 
                245                 250                 255     


Phe Leu Leu Asp Tyr Gln Gly Glu Leu Trp Ala Val Asp Arg Leu Gln 
            260                 265                 270         


Val Gln Glu Phe Met Leu Ser Phe Leu Arg Asp Pro Leu Arg Glu Ile 
        275                 280                 285             


Glu Glu Pro Tyr Phe Phe Leu Asp Glu Phe Val Thr Phe Leu Phe Ser 
    290                 295                 300                 


Lys Glu Asn Ser Val Trp Asn Ser Gln Leu Asp Ala Val Cys Pro Asp 
305                 310                 315                 320 


Thr Met Asn Asn Pro Leu Ser His Tyr Trp Ile Ser Ser Ser His Asn 
                325                 330                 335     


Thr Tyr Leu Thr Gly Asp Gln Phe Ser Ser Glu Ser Ser Leu Glu Ala 
            340                 345                 350         


Tyr Ala Arg Cys Leu Arg Met Gly Cys Arg Cys Ile Glu Leu Asp Cys 
        355                 360                 365             


Trp Asp Gly Pro Asp Gly Met Pro Val Ile Tyr His Gly His Thr Leu 
    370                 375                 380                 


Thr Thr Lys Ile Lys Phe Ser Asp Val Leu His Thr Ile Lys Glu His 
385                 390                 395                 400 


Ala Phe Val Ala Ser Glu Tyr Pro Val Ile Leu Ser Ile Glu Asp His 
                405                 410                 415     


Cys Ser Ile Ala Gln Gln Arg Asn Met Ala Gln Tyr Phe Lys Lys Val 
            420                 425                 430         


Leu Gly Asp Thr Leu Leu Thr Lys Pro Val Glu Ile Ser Ala Asp Gly 
        435                 440                 445             


Leu Pro Ser Pro Asn Gln Leu Lys Arg Lys Ile Leu Ile Lys His Lys 
    450                 455                 460                 


Lys Leu Ala Glu Gly Ser Ala Tyr Glu Glu Val Pro Thr Ser Met Met 
465                 470                 475                 480 


Tyr Ser Glu Asn Asp Ile Ser Asn Ser Ile Lys Asn Gly Ile Leu Tyr 
                485                 490                 495     


Leu Glu Asp Pro Val Asn His Glu Trp Tyr Pro His Tyr Phe Val Leu 
            500                 505                 510         


Thr Ser Ser Lys Ile Tyr Tyr Ser Glu Glu Thr Ser Ser Asp Gln Gly 
        515                 520                 525             


Asn Glu Asp Glu Glu Glu Pro Lys Glu Val Ser Ser Ser Thr Glu Leu 
    530                 535                 540                 


His Ser Asn Glu Lys Trp Phe His Gly Lys Leu Gly Ala Gly Arg Asp 
545                 550                 555                 560 


Gly Arg His Ile Ala Glu Arg Leu Leu Thr Glu Tyr Cys Ile Glu Thr 
                565                 570                 575     


Gly Ala Pro Asp Gly Ser Phe Leu Val Arg Glu Ser Glu Thr Phe Val 
            580                 585                 590         


Gly Asp Tyr Thr Leu Ser Phe Trp Arg Asn Gly Lys Val Gln His Cys 
        595                 600                 605             


Arg Ile His Ser Arg Gln Asp Ala Gly Thr Pro Lys Phe Phe Leu Thr 
    610                 615                 620                 


Asp Asn Leu Val Phe Asp Ser Leu Tyr Asp Leu Ile Thr His Tyr Gln 
625                 630                 635                 640 


Gln Val Pro Leu Arg Cys Asn Glu Phe Glu Met Arg Leu Ser Glu Pro 
                645                 650                 655     


Val Pro Gln Thr Asn Ala His Glu Ser Lys Glu Trp Tyr His Ala Ser 
            660                 665                 670         


Leu Thr Arg Ala Gln Ala Glu His Met Leu Met Arg Val Pro Arg Asp 
        675                 680                 685             


Gly Ala Phe Leu Val Arg Lys Arg Asn Glu Pro Asn Ser Tyr Ala Ile 
    690                 695                 700                 


Ser Phe Arg Ala Glu Gly Lys Ile Lys His Cys Arg Val Gln Gln Glu 
705                 710                 715                 720 


Gly Gln Thr Val Met Leu Gly Asn Ser Glu Phe Asp Ser Leu Val Asp 
                725                 730                 735     


Leu Ile Ser Tyr Tyr Glu Lys His Pro Leu Tyr Arg Lys Met Lys Leu 
            740                 745                 750         


Arg Tyr Pro Ile Asn Glu Glu Ala Leu Glu Lys Ile Gly Thr Ala Glu 
        755                 760                 765             


Pro Asp Tyr Gly Ala Leu Tyr Glu Gly Arg Asn Pro Gly Phe Tyr Val 
    770                 775                 780                 


Glu Ala Asn Pro Met Pro Thr Phe Lys Cys Ala Val Lys Ala Leu Phe 
785                 790                 795                 800 


Asp Tyr Lys Ala Gln Arg Glu Asp Glu Leu Thr Phe Ile Lys Ser Ala 
                805                 810                 815     


Ile Ile Gln Asn Val Glu Lys Gln Glu Gly Gly Trp Trp Arg Gly Asp 
            820                 825                 830         


Tyr Gly Gly Lys Lys Gln Leu Trp Phe Pro Ser Asn Tyr Val Glu Glu 
        835                 840                 845             


Met Val Asn Pro Val Ala Leu Glu Pro Glu Arg Glu His Leu Asp Glu 
    850                 855                 860                 


Asn Ser Pro Leu Gly Asp Leu Leu Arg Gly Val Leu Asp Val Pro Ala 
865                 870                 875                 880 


Cys Gln Ile Ala Ile Arg Pro Glu Gly Lys Asn Asn Arg Leu Phe Val 
                885                 890                 895     


Phe Ser Ile Ser Met Ala Ser Val Ala His Trp Ser Leu Asp Val Ala 
            900                 905                 910         


Ala Asp Ser Gln Glu Glu Leu Gln Asp Trp Val Lys Lys Ile Arg Glu 
        915                 920                 925             


Val Ala Gln Thr Ala Asp Ala Arg Leu Thr Glu Gly Lys Ile Met Glu 
    930                 935                 940                 


Arg Arg Lys Lys Ile Ala Leu Glu Leu Ser Glu Leu Val Val Tyr Cys 
945                 950                 955                 960 


Arg Pro Val Pro Phe Asp Glu Glu Lys Ile Gly Thr Glu Arg Ala Cys 
                965                 970                 975     


Tyr Arg Asp Met Ser Ser Phe Pro Glu Thr Lys Ala Glu Lys Tyr Val 
            980                 985                 990         


Asn Lys Ala Lys Gly Lys Lys Phe  Leu Gln Tyr Asn Arg  Leu Gln Leu 
        995                 1000                 1005             


Ser Arg  Ile Tyr Pro Lys Gly  Gln Arg Leu Asp Ser  Ser Asn Tyr 
    1010                 1015                 1020             


Asp Pro  Leu Pro Met Trp Ile  Cys Gly Ser Gln Leu  Val Ala Leu 
    1025                 1030                 1035             


Asn Phe  Gln Thr Pro Asp Lys  Pro Met Gln Met Asn  Gln Ala Leu 
    1040                 1045                 1050             


Phe Met  Thr Gly Arg His Cys  Gly Tyr Val Leu Gln  Pro Ser Thr 
    1055                 1060                 1065             


Met Arg  Asp Glu Ala Phe Asp  Pro Phe Asp Lys Ser  Ser Leu Arg 
    1070                 1075                 1080             


Gly Leu  Glu Pro Cys Ala Ile  Ser Ile Glu Val Leu  Gly Ala Arg 
    1085                 1090                 1095             


His Leu  Pro Lys Asn Gly Arg  Gly Ile Val Cys Pro  Phe Val Glu 
    1100                 1105                 1110             


Ile Glu  Val Ala Gly Ala Glu  Tyr Asp Ser Thr Lys  Gln Lys Thr 
    1115                 1120                 1125             


Glu Phe  Val Val Asp Asn Gly  Leu Asn Pro Val Trp  Pro Ala Lys 
    1130                 1135                 1140             


Pro Phe  His Phe Gln Ile Ser  Asn Pro Glu Phe Ala  Phe Leu Arg 
    1145                 1150                 1155             


Phe Val  Val Tyr Glu Glu Asp  Met Phe Ser Asp Gln  Asn Phe Leu 
    1160                 1165                 1170             


Ala Gln  Ala Thr Phe Pro Val  Lys Gly Leu Lys Thr  Gly Tyr Arg 
    1175                 1180                 1185             


Ala Val  Pro Leu Lys Asn Asn  Tyr Ser Glu Asp Leu  Glu Leu Ala 
    1190                 1195                 1200             


Ser Leu  Leu Ile Lys Ile Asp  Ile Phe Pro Ala Lys  Glu Asn Gly 
    1205                 1210                 1215             


Asp Leu  Ser Pro Phe Ser Gly  Thr Ser Leu Arg Glu  Arg Gly Ser 
    1220                 1225                 1230             


Asp Ala  Ser Gly Gln Leu Phe  His Gly Arg Ala Arg  Glu Gly Ser 
    1235                 1240                 1245             


Phe Glu  Ser Arg Tyr Gln Gln  Pro Phe Glu Asp Phe  Arg Ile Ser 
    1250                 1255                 1260             


Gln Glu  His Leu Ala Asp His  Phe Asp Ser Arg Glu  Arg Arg Ala 
    1265                 1270                 1275             


Pro Arg  Arg Thr Arg Val Asn  Gly Asp Asn Arg Leu  
    1280                 1285                 1290 


<210>  3914
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3914
gtgatagccg tcaaaggcag caaatagact gaatgaaaga tgagcttctg cctttatatc     60

cttctctcct gctacccaac tcattgtggt gaaggaaaaa gaaaacgcgg gtggagactg    120

cactatatgc ttaggactga aatgcaactg cagaagcaac atgtgacctt ttagagatgc    180

ttgtgggact gcataaagtg aagagggaaa ctggaaaaaa acaatgaaat tgaataggga    240

aaacctgctt tctgcaaaca actgaaaaag ctgcatttag aaactgtttc tttggccctc    300

atcgagaagc tggaacttgt attgttaggc cccttatggg acaagctctc aactgctgat    360

cacccagtga ttgtcaccat ggccagcaag aggaaatcca ccacaccatg catgatccca    420

gtgaagactg tggtgttgca agatgccagc atggaggccc agcccgctga gaccttgcct    480

gaaggacccc agcaggatct gcccccagaa gcatctgctg ccagcagtga ggcagcacag    540

aaccccagca gtactgatgg ctctacactg gccaatgggc atcggagcac tttagatggc    600

tatttatatt cctgtaaata ctgcgatttc agatcccatg acatgaccca atttgtggga    660

catatgaact cagagcacac agactttaat aaagacccaa cctttgtatg cagtgggtgc    720

agttttctgg caaaaacccc tgaggggctt tccttgcaca atgccacatg tcactccggg    780

gaagccagct ttgtgtggaa cgtggccaag ccagacaatc atgtggttgt ggagcagagc    840

atccctgaga gcaccagcac tcctgaccta gcgggtgagc ccagtgctga aggggctgat    900

ggacaggcag aaatcatcat taccaaaact ccaatcatga agataatgaa aggcaaagct    960

gaagccaaaa aaattcatac actcaaggag aatgtcccta gccagcctgt gggtgaggcc   1020

ttaccaaagc tgtcgactgg agaaatggag gtgagagagg gggaccattc cttcatcaat   1080

ggggcagttc cagtcagcca ggcatctgcc agctctgcaa aaaaccccca tgccgccaac   1140

gggcccctga taggaacagt gccagttttg ccagctggca tagcacagtt cctctccctc   1200

cagcagcagc ccccagtgca tgcccaacac catgtccacc agccactgcc cacggccaag   1260

gcccttccca aagtgatgat ccccctgagc agcattccaa cgtacaatgc agccatggac   1320

tctaacagct tcctgaagaa ctccttccac aagttcccct accccaccaa agccgagctc   1380

tgctatttga ctgtggtgac caagtatcca gaagaacagc tcaagatctg gttcacagcc   1440

caaaggctga agcaggggat cagctggtcc cctgaggaga ttgaggatgc ccggaaaaag   1500

atgttcaata cagtcatcca gtctgtgcct cagcccacaa ttacggttct aaatacccca   1560

ctcgtcgcca gtgctggcaa tgtccagcat ctcatccagg ccgctcttcc aggtcacgtt   1620

gtggggcagc cagagggtac aggaggggga cttctggtca ctcagccatt gatggccaat   1680

gggttgcaag caacaagttc ccctctcccc ctcacggtga catccgtccc caagcagcca   1740

ggtgtggcac ccattaacac tgtgtgttca aatacaacgt cagctgtgaa ggtggtcaat   1800

gcggcccagt cgctcctcac ggcctgcccc agcataacct cccaagcctt ccttgatgct   1860

agcatctaca aaaataagaa atctcatgaa cagctgtcag ctctgaaagg gagcttctgt   1920

cggaaccagt tcccagggca gagcgaagtt gaacatctca caaaagtgac gggcctcagt   1980

accagagagg tgcggaaatg gttcagtgat cgtagatacc actgccggaa cttgaagggc   2040

tccagagcga tgatacctgg agatcacagt tccatcatca ttgactctgt gccagaggtg   2100

tccttctccc catcgtccaa ggtccctgag gtaacctgca ttccgacaac agccacacta   2160

gcaacccacc cttctgccaa acgacaatct tggcaccaga ctcctgactt cacaccaacc   2220

aaatacaagg agagagcccc tgagcagctc agagccctgg agagcagttt tgcacaaaac   2280

cctcttcctc ttgatgagga actggaccgc ctgagaagtg aaaccaaaat gacccgacga   2340

gaaattgata gctggttttc agagagacgg aaaaaagtga atgctgagga gaccaagaag   2400

gctgaggaga atgcctctca ggaggaagag gaggctgctg aggatgaggg tggagaagag   2460

gatttggcca gtgagctaag ggtctctggt gaaaatggct ctctggaaat gcccagcagc   2520

catatcttgg cagagcgcaa agtcagcccc attaaaatca acctgaagaa cctgagggtc   2580

actgaagcca atggcaggaa cgagattcca gggctgggtg cctgtgaccc tgaggatgat   2640

gagtcaaaca aactggcaga gcagctccca ggcaaagtga gctgcaaaaa gactgcccag   2700

cagcggcact tgctgcggca gctctttgtc cagacacagt ggccaagcaa ccaggactat   2760

gactccatca tggcccagac gggtctgcca cggccagagg tggtgcgctg gtttggagat   2820

agcaggtacg cactgaagaa cggccaactc aaatggtacg aagactataa gcgaggcaac   2880

ttcccaccag ggctactggt cattgcccct ggcaaccggg agctcctgca ggactattac   2940

atgacacaca agatgctgta tgaagaggac ctgcagaacc tctgtgacaa gacccagatg   3000

agctcccagc aggtcaagca gtggtttgct gagaaaatgg gggaggagac cagagccgtg   3060

gcagacacag gcagtgagga ccagggccct ggtactggtg agctcacagc agttcacaaa   3120

gggatgggtg acacctattc agaggtgtct gagaacagtg agtcgtggga gccccgtgtc   3180

cctgaggcca gctcagagcc ctttgacaca tcgagtcccc aggctggacg tcagctcgaa   3240

acagactgaa tttgatctga ttaatgtgaa ggactggcca gtctgggaaa ccgcctgcca   3300

cgtggaagag ccaaacccga ctctctgctg ccacatgccg ttcccatgcc cggctgctgg   3360

gcacctggga gagcttccag aatcctcgca gacagcccag agcctgccgc taccctcggc   3420

ctgcccacca ccaagcaagc agcaagcaag atggggttct catcagttct tcctcccaca   3480

atgtaggacc tttcctttac cttccaatgg ataaaatagt tcagagttca tagtcatatt   3540

catagacaca gaatcaagct tttaacatat acatccacct ctatatgtta aataaaacat   3600

cagattatca acactgtcat tacgtagaaa ctttggttag ccaagcagtg cattgtcagt   3660

tacgtcatct ctaaaaatga cctgtgtctg ttctctgggg attgctgggt cacaggtgcc   3720

cctcaccttc cacagtcagg cagggaagtt ataggcacaa agctacgtct ggaacccctt   3780

tgtgccccct ttgtgttcct caaggaagca gtacctttga agagatctct gctgcattaa   3840

gtgatgaccg gctacgtttc atgtcaggct tgctttgcct tgtgggctac tcagtgcaga   3900

acctgctgta accctcagtt caaaaaatgg actggcaatg tgattagcgt tggatgcttt   3960

accattctct ttagttgtta ccgtaattct gctttttcat gggagtttga atcatggacc   4020

ataacttttc agttatcaga tcaactaaag aaacatttgt tgttaagcct aatgtgctga   4080

cctatgtgcc tgcatttttt ttttaatcta gacatgtttg gagtgagaga aagatggaaa   4140

aaagacatgg ggtagggacg taagtggaaa tctatagcca cagcctgaag ctttgaccac   4200

tgcggttttc agagcccttt ctccacactc atttcagagc ctcctatggt ttgggaagga   4260

ataacacact ggcccattag taagggtgaa ggctggaggg atttgttgac ttcttggaat   4320

tatcagaggt agggtggtct ttagcacaaa gacttgcatg cagagatccc tggcagaaca   4380

cccagagtgc ccgtggctcc caccccaggg tctggccggt gtgctggatg catgcccaag   4440

ggtgctgggc atcactggtc cttgtgagga tgcttttaaa gttttatatt tatgtcccca   4500

aacttggaaa caagaactct actttagcct aaccctcatg tccttttttg aattgagaaa   4560

attacaggaa atggtgcctt tgaaaattag aaaacttgct tacagagctg ttctaaatgg   4620

taaatcctca atttccccaa gaccggttgc tctgagagta gctggtaaag aggggcgaac   4680

taaagacctg tccacctgta gctccgctca tttcttagaa accacctgct tcccagagtg   4740

ccaagccaca agtaccaggc ttcgtgggca cagacacctc ctgggctggg cagagtgaca   4800

gtgctagaag accccagaga gagggcaagg gctttgggca agaagcactg gtggtgtttt   4860

agggaccgtc cttctcccct acccagggaa ctggacctgg cagggcaccg tgctcatgtg   4920

gctccaagga caagcatggc ggtggcccct tctgccttcc aggagaggtc ttgcttttga   4980

aaccaaaatc atgttcttct aaagtgtcat cttctgccct ccctgtccca atagggacca   5040

catcttattt gtctcaaaca gggacttgtg agtacttggc aagttttgca gcctattttt   5100

gtattcttaa tttggggagt aaagatgttt ggtctcaaaa acctttgagg aattgccaag   5160

aatggcgagt gattgctttc cttcagagaa cagacacttg gaatttctcc ttttagtgtt   5220

tatatacgtg cagattaatt tatatatata tatatacaca cacacatata cagtataaat   5280

actcatttga ttctcgtaaa acgcgcatct ggcgtgtgca gttgagaaac ttggtggcac   5340

atgggtgttg ggggagtagc ctgtgttgga gggacaccag tgcactaggc agctggggcg   5400

gcccaggctg aagccatctc cgggtgtctg agaaaccacc cagtgcctca cctccagatc   5460

ctgctggcat cacctccaga gccctgcatg cactggctga agagttggtc tgtggagagg   5520

attttcttgg ttacttgtat tcacggttaa tttacaaccc aaacagcaaa acacagttgg   5580

tggacaagtt catgcaggac ctacagtgac ccagccatgg gcactagctc atctttcagg   5640

tggaaaagta cagtgctgcc tgccctggta tgtttttctt atagatgtta gccctgccca   5700

acagccaggg ctacactaca aaaggcaaga atgcccatgt aaggagccca gcagtctgga   5760

cagatccttc ttcctctgct gttggatgag agtgagtgag tatgctctgg accttatcct   5820

tgaaagatga tcaaaagcga tgatgaggga ggcagtcatc acgcaggtgc ttaaagggac   5880

attgtaggag gtactcaagg gtttgggggc aaaaccctga atccagccag tcgtgcacag   5940

agacacaccc acactagccc agtggcagtg ggggatgtgg gatggcagca gccaggtatg   6000

tagccctgtc acaggacagc tcactgtggt tttgcacact gcctaagggt taaattgtgt   6060

tgttgccttc agtagaaggc atttgtgggc tgcagagttg agagttgggt gaggttagtc   6120

tctcctgaag aaaaagccta taaaaagtgg ctaatcttat cccttttctc tgtatgcagt   6180

tggactcgtc agagatagta aaatcatctt ttagtgtttt tttgttgctg atgtcttgta   6240

cccatttgtt ttttacatgg ggttgtagat cgagttctca aaggtgaaac cagatgatca   6300

ttctgataaa ggaaatttaa atttgataca tatgctttgt atattttgat tacttgtttt   6360

cgtttttgac tataaaggag cttttttatt ttgggagggg aggagtgtca tttttgagaa   6420

tcttgggttc ctgaaaaaga acgccctagt tggatggctt gccagggcct tggggtttgg   6480

tagtgattgt acaacttaaa gctcctttct cttggctgag tgacaggtgg ctgttcaggt   6540

ggaccaaagc accttgacac aaggactcca cactgtgctc tctagtagca caaggaggaa   6600

gttggacaga acattgggta gtgccttgcg ggctcacaca tgtactagtg gtctcatctc   6660

cagctagcct tgggaggccg tcccaccagg aaatctctct attccgtagc ctgagatgtg   6720

cccttgtggg ttttatcctg ctcagtcagt ggcctagggg caggtcctgt gttctctccc   6780

tctctctcct ggctctggga catctgtccc tggctgcctt tcatggagga aggacactgg   6840

cctttctggt tggatgctgt gtggatgctc tctgcttgag cctcgtggtc tcttgtctct   6900

ttttggacca atatcctcag attggtgcag ctttttcagt tcagatatca caccccaagt   6960

ggataaaggc aacttgcagg agaggagagc cagccaagaa gaaaatttta aaaccaaacc   7020

tcgtttagga ttttcctaaa gtcatcttct cttttttctt gctcagagtt tacctgggag   7080

atttcaccag tttgactcac catttgcaga tgtgcttttg tattaaattt aaattttcac   7140

atatcacatc cattctcaag gtagttatat gctggagaag aaaaatcctc tagacacatg   7200

aaggcccaca tagtcaagtc ttccagggca aagccagcag cccacccagg tcaggtagcc   7260

agcagggctc agttcccctc actccagaca cggaccctcc tcttcagggt ctcttgaccc   7320

agcttccttc tctcctttta cctgagagca cagacctctc tcagccagcc tgcccagacc   7380

acggggggct actcccatgt agtttgggga gcacttgatc tcagaaaagc tccattgtct   7440

gagcaaatgg gcagttgtgg agctcaagcc tttctcctgt gctcaagtcc cttccccaag   7500

caaggcttca acctcatcta cccaccatgt agttttctct ggccatttaa gtggggcggc   7560

agggacatgg ttgggccatg ccacaccagg gctggtgagg caaccagttt tgattttgac   7620

agagtggctg gaggaaaagt ggcaatcaag gtgctgcttg gtttgctctg agtgcaaatg   7680

gaaccaacag gtttctgctg caatctgtgt gttcccagtg ccaggtcaca ccaggagggg   7740

tggggcaggg ctaaccaagt ggtctctgaa ctcaccgagc gtctgcactt ggttgtgaag   7800

ttaatgggag tacagagagc gtctggcctt ggagaggggt tgagagcctc ctttttggtt   7860

cttcattcct gagctcttgc ctgcccacaa atctgacctc tttgaatggg gacgcagtcc   7920

ttcaacagag aagtttctat ggcaaagaag tttctattta gctctagatc cagcagagtc   7980

atccattcta actgccctga agtctagagc aggggaggga acccagaggc tggggatgag   8040

actaggcaga ccctggttac catatggaca aggacagggg aaagcacccc cttcctcaat   8100

ttctgaaagt tctatctttg ggttcgcagg actttgagga tgataaagaa catataggta   8160

ctagcttgtt gttgctggtc caaagcttcc ac                                 8192


<210>  3915
<211>  956
<212>  PRT
<213>  Homosapiens

<400>  3915

Met Ala Ser Lys Arg Lys Ser Thr Thr Pro Cys Met Ile Pro Val Lys 
1               5                   10                  15      


Thr Val Val Leu Gln Asp Ala Ser Met Glu Ala Gln Pro Ala Glu Thr 
            20                  25                  30          


Leu Pro Glu Gly Pro Gln Gln Asp Leu Pro Pro Glu Ala Ser Ala Ala 
        35                  40                  45              


Ser Ser Glu Ala Ala Gln Asn Pro Ser Ser Thr Asp Gly Ser Thr Leu 
    50                  55                  60                  


Ala Asn Gly His Arg Ser Thr Leu Asp Gly Tyr Leu Tyr Ser Cys Lys 
65                  70                  75                  80  


Tyr Cys Asp Phe Arg Ser His Asp Met Thr Gln Phe Val Gly His Met 
                85                  90                  95      


Asn Ser Glu His Thr Asp Phe Asn Lys Asp Pro Thr Phe Val Cys Ser 
            100                 105                 110         


Gly Cys Ser Phe Leu Ala Lys Thr Pro Glu Gly Leu Ser Leu His Asn 
        115                 120                 125             


Ala Thr Cys His Ser Gly Glu Ala Ser Phe Val Trp Asn Val Ala Lys 
    130                 135                 140                 


Pro Asp Asn His Val Val Val Glu Gln Ser Ile Pro Glu Ser Thr Ser 
145                 150                 155                 160 


Thr Pro Asp Leu Ala Gly Glu Pro Ser Ala Glu Gly Ala Asp Gly Gln 
                165                 170                 175     


Ala Glu Ile Ile Ile Thr Lys Thr Pro Ile Met Lys Ile Met Lys Gly 
            180                 185                 190         


Lys Ala Glu Ala Lys Lys Ile His Thr Leu Lys Glu Asn Val Pro Ser 
        195                 200                 205             


Gln Pro Val Gly Glu Ala Leu Pro Lys Leu Ser Thr Gly Glu Met Glu 
    210                 215                 220                 


Val Arg Glu Gly Asp His Ser Phe Ile Asn Gly Ala Val Pro Val Ser 
225                 230                 235                 240 


Gln Ala Ser Ala Ser Ser Ala Lys Asn Pro His Ala Ala Asn Gly Pro 
                245                 250                 255     


Leu Ile Gly Thr Val Pro Val Leu Pro Ala Gly Ile Ala Gln Phe Leu 
            260                 265                 270         


Ser Leu Gln Gln Gln Pro Pro Val His Ala Gln His His Val His Gln 
        275                 280                 285             


Pro Leu Pro Thr Ala Lys Ala Leu Pro Lys Val Met Ile Pro Leu Ser 
    290                 295                 300                 


Ser Ile Pro Thr Tyr Asn Ala Ala Met Asp Ser Asn Ser Phe Leu Lys 
305                 310                 315                 320 


Asn Ser Phe His Lys Phe Pro Tyr Pro Thr Lys Ala Glu Leu Cys Tyr 
                325                 330                 335     


Leu Thr Val Val Thr Lys Tyr Pro Glu Glu Gln Leu Lys Ile Trp Phe 
            340                 345                 350         


Thr Ala Gln Arg Leu Lys Gln Gly Ile Ser Trp Ser Pro Glu Glu Ile 
        355                 360                 365             


Glu Asp Ala Arg Lys Lys Met Phe Asn Thr Val Ile Gln Ser Val Pro 
    370                 375                 380                 


Gln Pro Thr Ile Thr Val Leu Asn Thr Pro Leu Val Ala Ser Ala Gly 
385                 390                 395                 400 


Asn Val Gln His Leu Ile Gln Ala Ala Leu Pro Gly His Val Val Gly 
                405                 410                 415     


Gln Pro Glu Gly Thr Gly Gly Gly Leu Leu Val Thr Gln Pro Leu Met 
            420                 425                 430         


Ala Asn Gly Leu Gln Ala Thr Ser Ser Pro Leu Pro Leu Thr Val Thr 
        435                 440                 445             


Ser Val Pro Lys Gln Pro Gly Val Ala Pro Ile Asn Thr Val Cys Ser 
    450                 455                 460                 


Asn Thr Thr Ser Ala Val Lys Val Val Asn Ala Ala Gln Ser Leu Leu 
465                 470                 475                 480 


Thr Ala Cys Pro Ser Ile Thr Ser Gln Ala Phe Leu Asp Ala Ser Ile 
                485                 490                 495     


Tyr Lys Asn Lys Lys Ser His Glu Gln Leu Ser Ala Leu Lys Gly Ser 
            500                 505                 510         


Phe Cys Arg Asn Gln Phe Pro Gly Gln Ser Glu Val Glu His Leu Thr 
        515                 520                 525             


Lys Val Thr Gly Leu Ser Thr Arg Glu Val Arg Lys Trp Phe Ser Asp 
    530                 535                 540                 


Arg Arg Tyr His Cys Arg Asn Leu Lys Gly Ser Arg Ala Met Ile Pro 
545                 550                 555                 560 


Gly Asp His Ser Ser Ile Ile Ile Asp Ser Val Pro Glu Val Ser Phe 
                565                 570                 575     


Ser Pro Ser Ser Lys Val Pro Glu Val Thr Cys Ile Pro Thr Thr Ala 
            580                 585                 590         


Thr Leu Ala Thr His Pro Ser Ala Lys Arg Gln Ser Trp His Gln Thr 
        595                 600                 605             


Pro Asp Phe Thr Pro Thr Lys Tyr Lys Glu Arg Ala Pro Glu Gln Leu 
    610                 615                 620                 


Arg Ala Leu Glu Ser Ser Phe Ala Gln Asn Pro Leu Pro Leu Asp Glu 
625                 630                 635                 640 


Glu Leu Asp Arg Leu Arg Ser Glu Thr Lys Met Thr Arg Arg Glu Ile 
                645                 650                 655     


Asp Ser Trp Phe Ser Glu Arg Arg Lys Lys Val Asn Ala Glu Glu Thr 
            660                 665                 670         


Lys Lys Ala Glu Glu Asn Ala Ser Gln Glu Glu Glu Glu Ala Ala Glu 
        675                 680                 685             


Asp Glu Gly Gly Glu Glu Asp Leu Ala Ser Glu Leu Arg Val Ser Gly 
    690                 695                 700                 


Glu Asn Gly Ser Leu Glu Met Pro Ser Ser His Ile Leu Ala Glu Arg 
705                 710                 715                 720 


Lys Val Ser Pro Ile Lys Ile Asn Leu Lys Asn Leu Arg Val Thr Glu 
                725                 730                 735     


Ala Asn Gly Arg Asn Glu Ile Pro Gly Leu Gly Ala Cys Asp Pro Glu 
            740                 745                 750         


Asp Asp Glu Ser Asn Lys Leu Ala Glu Gln Leu Pro Gly Lys Val Ser 
        755                 760                 765             


Cys Lys Lys Thr Ala Gln Gln Arg His Leu Leu Arg Gln Leu Phe Val 
    770                 775                 780                 


Gln Thr Gln Trp Pro Ser Asn Gln Asp Tyr Asp Ser Ile Met Ala Gln 
785                 790                 795                 800 


Thr Gly Leu Pro Arg Pro Glu Val Val Arg Trp Phe Gly Asp Ser Arg 
                805                 810                 815     


Tyr Ala Leu Lys Asn Gly Gln Leu Lys Trp Tyr Glu Asp Tyr Lys Arg 
            820                 825                 830         


Gly Asn Phe Pro Pro Gly Leu Leu Val Ile Ala Pro Gly Asn Arg Glu 
        835                 840                 845             


Leu Leu Gln Asp Tyr Tyr Met Thr His Lys Met Leu Tyr Glu Glu Asp 
    850                 855                 860                 


Leu Gln Asn Leu Cys Asp Lys Thr Gln Met Ser Ser Gln Gln Val Lys 
865                 870                 875                 880 


Gln Trp Phe Ala Glu Lys Met Gly Glu Glu Thr Arg Ala Val Ala Asp 
                885                 890                 895     


Thr Gly Ser Glu Asp Gln Gly Pro Gly Thr Gly Glu Leu Thr Ala Val 
            900                 905                 910         


His Lys Gly Met Gly Asp Thr Tyr Ser Glu Val Ser Glu Asn Ser Glu 
        915                 920                 925             


Ser Trp Glu Pro Arg Val Pro Glu Ala Ser Ser Glu Pro Phe Asp Thr 
    930                 935                 940                 


Ser Ser Pro Gln Ala Gly Arg Gln Leu Glu Thr Asp 
945                 950                 955     


<210>  3916
<211>  3827
<212>  DNA
<213>  Homosapiens

<400>  3916
cgcctcccct ccgcggcccc agccgctagc agcgccggcc actccgcggg acgcagccgc     60

cgcgaagcgc caggcggccg ggccagcgag ctcgggggcc gaaggggacc ccgggaccct    120

cggggcggga cccgggccga ccagcggcgg gggcggcgcg gcgctgcagg cggacacccg    180

gcggggggca ccgcgcgggg ccgggcagag gcgcgggggc cgctatgggc cgccgccgcc    240

tgctcgtctg gctgtgcgcc gtcgcggcgc tgctctcggg ggcgcaggcc aggggcaccc    300

cgctcctggc gcggcctgcg ccgcccggtg cctcccgcta cagtctctac acgacgggat    360

ggcgcccgcg gctgcgcccg gggccgcaca aggccctctg tgcctatgtg gtgcacagga    420

atgtgacctg catcctacag gagggagcgg agagctacgt aaaggctgaa taccggcagt    480

gtagatgggg gcccaagtgc cccgggacag tcacgtaccg cacagtactc agacccaaat    540

acaaggttgg ctacaagaca gtgacagacc tcgcctggcg ttgctgtccc ggcttcactg    600

ggaaacgctg ccctgagcac ctcacggacc atggggctgc ctcaccccag ctggagcctg    660

agcctcagat tccttcaggg cagctggacc caggccccag gcccccttcc tacagcagag    720

cagcccccag ccctcatgga aggaaaggcc cagggctgtt tggtgagcgg ctggaacgcc    780

tggagggtga tgtccagcgc ctggctcaaa catatggtac cctcagtggc ctggtggcta    840

gccacgagga tcccaacagg atgactggtg gccccagggc tcctgctgtc cctgtgggct    900

ttggggtcat ccctgagggg cttgtgggcc caggagacag agccagaggg ccactaacac    960

ctcccttaga cgagatccta agcaaggtga cagaggtgag caacactctt cagaccaagg   1020

tgcagcttct agacaaggtg catgggctgg cacttggcca tgaggcccac ctgcagcggc   1080

tgcgggaagc cccaccatcc ccgctcacct ccctggccct gctggaggag tacgtggacc   1140

gacggctgca ccgactctgg gggagcctgc tggatggctt tgagcagaag ctgcaaggcg   1200

tccagagtga gtgtgacctg cgggtgcagg aggtacggcg gcaatgtgag gagggtcagg   1260

ccgccagccg gaggctgcac cagagccttg atggccggga gctggccctg cgccaggagc   1320

tgtcacagct gggcagccag ctgcagggcc tgagcgtgtc tggcaggggc agctgctgtg   1380

ggcaactagc cttgatcaat gcccgtatgg atggccttga gagggccctg caggcagtca   1440

ccgagaccca aaggggcccc ggtgccccgg ccggggatga gcttacgagg ctctctgctg   1500

ccatgctcga gggaggtgtg gacgggctgc ttgagggtct ggagacgctc aatgggacag   1560

agggtggagc aaggggatgc tgtctgaggt tggacatggg ggggtgggga gtgggcggct   1620

ttgggaccat gctggaagag cgcgtgcaga gcctcgagga gcgcctagca acattggctg   1680

gggagctaag ccatgacagc gcctctccgg gcaggtcagc tcggcccctt gtacagacag   1740

agctggctgt gctagagcaa cggttggtct cactggagac ttcgtgcacc ccgagcacca   1800

cctcagccat cctggacagc ctcgtggcag aggtgaaggc ctggcagagc cggagcgagg   1860

ccctcctacg ccaggtggcc agccacgcag cactgctcca gcagctcaat ggcactgtgg   1920

ccgaggtcca gggacagctg gcagaaggga cgggcagctc acttcaaggc gagatcactc   1980

tgctcaaggt caatctgaac tcagtgagca agtcgctcac aggcctcagt gactctgtca   2040

gccagtactc tgatgccttc ttggctgcca acacgtccct ggatgagcgg gaacgcaagg   2100

tggaagccga agtccaggcc atccaggagc aggtcagcag ccaaggctcc aggcttcagg   2160

ctggccacag gcaggtcctg aacctgcgtg gggagctgga gcaactcaag gctggtgtgg   2220

ccaaggtggc cagtgggctg agccgctgcc aggacacagc ccagaaactt cagcacacag   2280

tgggacactt tgaccagcgg gtggcacaag tggagggtgc gtgcaggagg ctgggcctgc   2340

tggccgcggg cctggacagc ttgcccactg agccactgag gcccagagag ggcctgtgga   2400

gccatgtgga ccagctgaat cgtacgctgg cccagcacac gcaggacatt gcccgcctcc   2460

gggatgacct actggactgc caggcccagc tggctgagca ggtgcggcca gggcaagcca   2520

actagacagg ctggccagga cccaacccct agatcccacc aactcgggga acatcacccc   2580

agagcccagc cttatccagc agcgccttcc agccttccct ggctagccca aatggcacta   2640

aggaggccac tgagggaatc ctccacgtgg ctgtcccagc caccaaaacc catgcacagt   2700

gctgcagaaa ctggacagtt ccggacagcg gtcaaggcaa ggatgtcatg cttgaaggcc   2760

agggtagact tgagagagtt cacattccac tgtcagcaaa tcagtgtctg gacagccagc   2820

tgcagggcct gagcatggct ggcaggggca gctgctgtgg caaactggcc ttgatcagtg   2880

tccgtatgta aggccttgag aggaccctgc aggcagtcag caccagcctc agcaactgtg   2940

cagagaccta caggcccaca gccagtggcc tgtccgcatt gccctgtgcc cacaagcaac   3000

agtccacagc ccttggtggc ttctgttcct tgtcccctcg gcttctcttc gcagccatca   3060

ggactaggtt tgtgcaggaa ggtgatgccc actggaactc tcctcacacc tggcagcttc   3120

atggatgttg tatctgaact aaggaccaga ggctgccaga tgtttctggc tcctcacgtg   3180

tccttcagga cagaacagaa gcacaaagac tcagccaaga gttctcttta ttccctttga   3240

tcctccccca aggtgagggc ttaggcagct gtagaacccc aggaaagaac ggaatccagg   3300

caatctgttt agagaccccc cactccaaat ttatcctttt cctttccttc ccctaagatg   3360

tttccagggc cctctggtgc ccacactgtc ctcttccttc cacttggggg tggggaaatc   3420

cttcctgcga ggtcagggca tttctctaca aagtggcctg aatgaggcca ggccctgaga   3480

aggagccacc agctggagga aaggggctcc aagccttgct tttaacaccc ctgcaaaacc   3540

cccaccctcc caagatgttc acaaaaggtg agaaattcag gtacgaaacc atcaatggac   3600

aacttgaaaa tgcatgttcc tcaggcctat gcagttccca gagactcttg acaccggtct   3660

ctgctgaggc tcccagcctc agtttccccc acagcagcac gggccccact gtgctgctct   3720

tcaggtcccc acagccctgc ctttggttcc tggacatttg gtattctgcc ctccactctg   3780

gtactatcag agtagggcag gctctggatt aaagctttta gccggtc                 3827


<210>  3917
<211>  766
<212>  PRT
<213>  Homosapiens

<400>  3917

Met Gly Arg Arg Arg Leu Leu Val Trp Leu Cys Ala Val Ala Ala Leu 
1               5                   10                  15      


Leu Ser Gly Ala Gln Ala Arg Gly Thr Pro Leu Leu Ala Arg Pro Ala 
            20                  25                  30          


Pro Pro Gly Ala Ser Arg Tyr Ser Leu Tyr Thr Thr Gly Trp Arg Pro 
        35                  40                  45              


Arg Leu Arg Pro Gly Pro His Lys Ala Leu Cys Ala Tyr Val Val His 
    50                  55                  60                  


Arg Asn Val Thr Cys Ile Leu Gln Glu Gly Ala Glu Ser Tyr Val Lys 
65                  70                  75                  80  


Ala Glu Tyr Arg Gln Cys Arg Trp Gly Pro Lys Cys Pro Gly Thr Val 
                85                  90                  95      


Thr Tyr Arg Thr Val Leu Arg Pro Lys Tyr Lys Val Gly Tyr Lys Thr 
            100                 105                 110         


Val Thr Asp Leu Ala Trp Arg Cys Cys Pro Gly Phe Thr Gly Lys Arg 
        115                 120                 125             


Cys Pro Glu His Leu Thr Asp His Gly Ala Ala Ser Pro Gln Leu Glu 
    130                 135                 140                 


Pro Glu Pro Gln Ile Pro Ser Gly Gln Leu Asp Pro Gly Pro Arg Pro 
145                 150                 155                 160 


Pro Ser Tyr Ser Arg Ala Ala Pro Ser Pro His Gly Arg Lys Gly Pro 
                165                 170                 175     


Gly Leu Phe Gly Glu Arg Leu Glu Arg Leu Glu Gly Asp Val Gln Arg 
            180                 185                 190         


Leu Ala Gln Thr Tyr Gly Thr Leu Ser Gly Leu Val Ala Ser His Glu 
        195                 200                 205             


Asp Pro Asn Arg Met Thr Gly Gly Pro Arg Ala Pro Ala Val Pro Val 
    210                 215                 220                 


Gly Phe Gly Val Ile Pro Glu Gly Leu Val Gly Pro Gly Asp Arg Ala 
225                 230                 235                 240 


Arg Gly Pro Leu Thr Pro Pro Leu Asp Glu Ile Leu Ser Lys Val Thr 
                245                 250                 255     


Glu Val Ser Asn Thr Leu Gln Thr Lys Val Gln Leu Leu Asp Lys Val 
            260                 265                 270         


His Gly Leu Ala Leu Gly His Glu Ala His Leu Gln Arg Leu Arg Glu 
        275                 280                 285             


Ala Pro Pro Ser Pro Leu Thr Ser Leu Ala Leu Leu Glu Glu Tyr Val 
    290                 295                 300                 


Asp Arg Arg Leu His Arg Leu Trp Gly Ser Leu Leu Asp Gly Phe Glu 
305                 310                 315                 320 


Gln Lys Leu Gln Gly Val Gln Ser Glu Cys Asp Leu Arg Val Gln Glu 
                325                 330                 335     


Val Arg Arg Gln Cys Glu Glu Gly Gln Ala Ala Ser Arg Arg Leu His 
            340                 345                 350         


Gln Ser Leu Asp Gly Arg Glu Leu Ala Leu Arg Gln Glu Leu Ser Gln 
        355                 360                 365             


Leu Gly Ser Gln Leu Gln Gly Leu Ser Val Ser Gly Arg Gly Ser Cys 
    370                 375                 380                 


Cys Gly Gln Leu Ala Leu Ile Asn Ala Arg Met Asp Gly Leu Glu Arg 
385                 390                 395                 400 


Ala Leu Gln Ala Val Thr Glu Thr Gln Arg Gly Pro Gly Ala Pro Ala 
                405                 410                 415     


Gly Asp Glu Leu Thr Arg Leu Ser Ala Ala Met Leu Glu Gly Gly Val 
            420                 425                 430         


Asp Gly Leu Leu Glu Gly Leu Glu Thr Leu Asn Gly Thr Glu Gly Gly 
        435                 440                 445             


Ala Arg Gly Cys Cys Leu Arg Leu Asp Met Gly Gly Trp Gly Val Gly 
    450                 455                 460                 


Gly Phe Gly Thr Met Leu Glu Glu Arg Val Gln Ser Leu Glu Glu Arg 
465                 470                 475                 480 


Leu Ala Thr Leu Ala Gly Glu Leu Ser His Asp Ser Ala Ser Pro Gly 
                485                 490                 495     


Arg Ser Ala Arg Pro Leu Val Gln Thr Glu Leu Ala Val Leu Glu Gln 
            500                 505                 510         


Arg Leu Val Ser Leu Glu Thr Ser Cys Thr Pro Ser Thr Thr Ser Ala 
        515                 520                 525             


Ile Leu Asp Ser Leu Val Ala Glu Val Lys Ala Trp Gln Ser Arg Ser 
    530                 535                 540                 


Glu Ala Leu Leu Arg Gln Val Ala Ser His Ala Ala Leu Leu Gln Gln 
545                 550                 555                 560 


Leu Asn Gly Thr Val Ala Glu Val Gln Gly Gln Leu Ala Glu Gly Thr 
                565                 570                 575     


Gly Ser Ser Leu Gln Gly Glu Ile Thr Leu Leu Lys Val Asn Leu Asn 
            580                 585                 590         


Ser Val Ser Lys Ser Leu Thr Gly Leu Ser Asp Ser Val Ser Gln Tyr 
        595                 600                 605             


Ser Asp Ala Phe Leu Ala Ala Asn Thr Ser Leu Asp Glu Arg Glu Arg 
    610                 615                 620                 


Lys Val Glu Ala Glu Val Gln Ala Ile Gln Glu Gln Val Ser Ser Gln 
625                 630                 635                 640 


Gly Ser Arg Leu Gln Ala Gly His Arg Gln Val Leu Asn Leu Arg Gly 
                645                 650                 655     


Glu Leu Glu Gln Leu Lys Ala Gly Val Ala Lys Val Ala Ser Gly Leu 
            660                 665                 670         


Ser Arg Cys Gln Asp Thr Ala Gln Lys Leu Gln His Thr Val Gly His 
        675                 680                 685             


Phe Asp Gln Arg Val Ala Gln Val Glu Gly Ala Cys Arg Arg Leu Gly 
    690                 695                 700                 


Leu Leu Ala Ala Gly Leu Asp Ser Leu Pro Thr Glu Pro Leu Arg Pro 
705                 710                 715                 720 


Arg Glu Gly Leu Trp Ser His Val Asp Gln Leu Asn Arg Thr Leu Ala 
                725                 730                 735     


Gln His Thr Gln Asp Ile Ala Arg Leu Arg Asp Asp Leu Leu Asp Cys 
            740                 745                 750         


Gln Ala Gln Leu Ala Glu Gln Val Arg Pro Gly Gln Ala Asn 
        755                 760                 765     


<210>  3918
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3918
atgaccaatg ggtctgtgtt ttggaccggc gaagcccaat ggcgcgacag ggaaggcggg     60

cccgagatgg gttagggtgt ccttgcaggg tgtctgagct aaacttcacc aaataatagc    120

tgtttgtatt ttggctgctg caggagccat tttagaaata aatatcttcc ttcaatagat    180

gaaaatgaaa atacagaaaa aagagaagca gttgtcaaat ttaaaagttt tgaatcactc    240

cccaatgtct gatgcctctg tcaattttga ctacaaatct ccatccccat ttgactgcag    300

cactgatcaa gaagagaaaa ttgaagatgt tgctagtcac tgtctgcctc agaaggacct    360

gtatactgct gaagaggaag ctgctaccct ttttcctagg aaaatgacat cccataatgg    420

gatggaggac agtggaggag gaggtactgg agtgaagaag aaacggaaga aaaaggagcc    480

aggagaccaa gagggtgcag caaagggaag caaggacaga gagcccaagc caaagaggaa    540

acgagaaccg aaagagccaa aggaacccag aaaggccaag gagccgaaga aggccaagga    600

gcacaaggag ccgaagcaaa aagatggggc aaagaaggca cggaagcccc gggaggcctc    660

gggcaccaag gaggccaaag agaagaggag ctgcactgac tctgcagcca ggacgaagtc    720

caggaaggcc agcaaggagc aaggaccaac cccagtggag aaaaagaaga aaggaaaaag    780

gaaaagtgaa actacagtgg agagtttaga gctggatcag ggcctgacga acccatctct    840

gcggagtcct gaggagtcca ctgagtctac agacagccag aaacgacgct cgggaaggca    900

agtaaagcgc agaaaataca atgaggacct ggacttcaaa gtggtggatg atgatgggga    960

aacaattgct gttcttggag ctggtcgaac atctgcactc tcagcctcta cactggcctg   1020

gcaggcggag gagcctccag aagatgatgc aaacatcatt gagaagatcc tggcatctaa   1080

gactgtccag gaggttcacc caggagaacc tccgttcgac ttggagctgt tctacgttaa   1140

gtatagaaat ttttcctact tacattgtaa atgggccaca atggaagagc tcgaaaagga   1200

tcctcgcatc gcacagaaga tcaagcgatt taggaataaa caagcccaga tgaagcacat   1260

ttttacggag cctgatgaag acttgttcaa tccagactat gtagaagttg atcgcatctt   1320

ggaggtggcc cacaccaagg atgcagaaac aggggaggag gtaacacatt acctggtgaa   1380

gtggtgctca ctaccatatg aagaaagcac gtgggagcta gaggaagatg tagatcctgc   1440

aaaagttaaa gaatttgaat ctcttcaagt tctccctgaa attaagcatg tggagcggcc   1500

tgcttcagac tcctggcaga aacttgagaa gtctcgcgag tataagaaca gtaaccagct   1560

ccgggagtac cagctggaag ggatgaactg gcttcttttt aactggtata acagaaaaaa   1620

ctgtattttg gctgatgaga tgggcctagg gaaaaccatc cagtccatca cattcctttc   1680

agaaatattt ctgagaggaa tccacggccc ttttctcatt atcgcccctc tctccaccat   1740

cactaactgg gagcgggagt tccggacatg gacagagatg aatgccattg tgtaccacgg   1800

cagccagatc agcaggcaga tgatccagca gtatgaaatg gtgtacagag acgcccaggg   1860

aaaccccctt tcaggagtct tcaagttcca cgtcgtcatc acaacatttg aaatgatcct   1920

agcagactgc ccagagttga agaagattca ctggagctgt gtgataattg atgaagccca   1980

cagactgaag aataggaact gcaaacttct ggagggtcta aagcttatgg ccctggaaca   2040

taaagtgctt ctcactggaa cacccttgca gaactctgtg gaggagctct tcagtttgtt   2100

aaattttctg gagccatcac agtttccttc agagaccgct ttcttggagg aatttggaga   2160

tctgaaaaca gaggagcagg taaagaaact gcagtctatc ctaaaaccaa tgatgcttcg   2220

gcggctgaaa gatgatgtgg aaaagaacct tgctcccaaa caagagacga tcattgaggt   2280

ggaactgacc aatatccaga aaaagtacta ccgtgccatc ctcgagaaga acttttcctt   2340

cctgaccaag ggggcaaatc agcacaacat gcccaatctc atcaacacca tgatggagct   2400

gaggaagtgc tgtaaccatc cctacctgat caatggagca gaggagaaaa ttctagaaga   2460

tttccgaaaa acccacagcc ctgatgcccc tgactttcag ctgcaggcca tgattcaggc   2520

agcaggaaag cttgtgttga ttgataaact actccctaag ctgattgcag gtggccacaa   2580

agtactcatc ttctcccaga tggtgcgctg cctcgacatc ctagaagatt acctcatcca   2640

gagaagatac acctatgagc gaattgatgg gcgagtacgg ggaaacctgc gccaggcagc   2700

catcgaccgg ttctgtaagc cagattcaga ccgctttgtc tttcttctgt gcaccagagc   2760

gggaggcctg gggatcaatc tcacagctgc tgatacctgc atcatatttg attctgactg   2820

gaacccacaa aatgacttgc aggctcaggc ccgatgtcac cgcataggcc agagcaaagc   2880

tgtgaaggtg tatcgcctca tcactcgaaa ttcctacgag cgcgagatgt ttgacaaggc   2940

cagcctaaag ctggggctgg acaaggctgt tcttcaggac atcaaccgaa agggcggcac   3000

caatggggta cagcagctct caaaaatgga ggtggaggac ctactccgga aaggtgctta   3060

tggagcctta atggatgaag aagatgaagg ctccaagttc tgtgaagaag acatagacca   3120

gattctgcag aggcgaacgc acaccatcac catccagtct gaggggaaag ggtccacttt   3180

tgccaaggct agctttgtgg cttcaggaaa cagaacagat atttccttag atgatcctaa   3240

cttttggcag aaatgggcta aaatagctga actagacact gaagcaaaga atgaaaagga   3300

aagcttagtg atcgaccgac ctcgcgtgag aaagcagacc aaacactaca actcgtttga   3360

ggaagacgag ctcatggagt tttcagagtt agacagcgac tcagacgaaa ggcccacgag   3420

atccaggcgc ctcaatgaca aagccaggcg ctacctccga gcggagtgct tccgggtaga   3480

gaagaacctg ctcatctttg gctggggccg gtggaaggac atcctgactc atggccgatt   3540

caagtggcat ctgaacgaga aggacatgga gatgatttgc cgtgccctcc tggtgtactg   3600

tgtcaagcat tataaggggg acgagaagat caagagtttc atttgggaac tgatcacacc   3660

taccaaagat gggcaagccc agaccctcca gaaccactca ggcttatctg ccccagtccc   3720

cagagggagg aaggggaaga agacgaagaa ccagttgcta atcccagagc taaaggatgc   3780

agattggcta gccacctgca accccgaggt ggtcttgcat gatgatggct ataagaaaca   3840

cctcaaacag cactgcaaca aagtactttt gcgagtccgg atgctgtact acctaaaagc   3900

tgaaatactg ggagaagcag ctgagaaagc atttgaagga tctcctgcca gggagctgga   3960

tgtacctctg cctgacatcg actacatgga gatcccagtg gactggtggg atgctgaagc   4020

cgataagtca cttctcattg gcgtgttcaa gcatggttat gaaaggtaca atgccatgcg   4080

agcagaccca gcactttgct tcctggagaa agttgggatg cccgatgaga agtccctttc   4140

tgcagaacag ggtgttacag atgggacctc agacattcct gaaagaggca acacagataa   4200

agaagacaat gctgaggaca aagtagatgg cctccagaaa caaacggaga gttccagtga   4260

tggaggtgat ggcgttttta gcgaaaagaa ggatgacagc cgggcagccc aggatggctc   4320

cgacccagac aaatcgccct ggccagtttc ctccgccctc acagctcgtc tcagacgtct   4380

ggtcactgtt taccagcgct gcaaccgcaa ggaactgtgc cggcctgaaa ttctgggacc   4440

aggtaaccaa ggatattggg ttcaggaaga gatgttcagg agaacctcag aaatggacct   4500

catcaacaag gaagcccaaa agaggtggac taggagagaa caagcagact tctatagaac   4560

agtgtcttcc tttggtgttg tttacgatca agaaaagaaa acctttgact ggacacagtt   4620

ccgcatcatt tcccgtttgg acaagaagtc ggatgagagc ctggaacagt atttttatag   4680

ttttgtggcc atgtgccgga atgtctgtcg tctacccaca tggaaagatg gcggtccccc   4740

agataccacc atctacgttg aacccatcac tgaggaacgt gctgcaagaa ctctgtaccg   4800

cattgaactg ttacggaaag tccgagagca agtgctcaag tgccctcagc tgcatgaacg   4860

cctccagctg tgcaggccca gcctctacct cccagtctgg tgggagtgtg ggaagcatga   4920

tcgagacctg ctcatcggca ctgccaaaca tgggctgaac cgcactgact gttacatcat   4980

gaacgacccc cagctgtcct tcctggatgc ctatagaaac tatgcccagc ataaaagatc   5040

tggcacccag gcaccaggaa atctctgttg cctttaccag accaactcca agttatatga   5100

atctcttaca tattctcaaa tgagtaggac ttcagagtcc cttgaaaatg aacctgaaaa   5160

tctagtgaga gtagaaagca gagatgatca tctcagcctg cctgatgtga catgtgaaaa   5220

ctttatttct aaagttcagg atgtcatttc catcaaccat gatgaaagtc tgctgcctga   5280

gtccttagag agcatgatgt atggtaagaa ggtgctcagc caagaaccaa gctcttttca   5340

ggagagccca agtaccaata ctgaatctag aaaagatgtt attaccatct caataagcaa   5400

agatgggaac tgccagtctg gtggccctga ggcagaaata gcttctggcc ctacttttat   5460

gggtagctta gaagcaggag gagtagctca agcaaacatc aaaaatggaa aacatttgtt   5520

gatgtctatt tcaaaggaag gggagctctg ctgcagtgag gcaggacaga gacctgaaaa   5580

cattggccag ctggaagcca agtgtttagc ttccccttcc ttgaatccag gaaatgaaag   5640

tgggtttgta gatatgtgca gtcttagtgt ctgtgactcc aaaagaaacc tgtcatcaga   5700

tcagcaatta attgatttat tggaaaacaa aagcttagaa agtaaattga ttttgagtca   5760

gaaccacagt gatgaggagg aagaagagga ggaaaacgag gaggaaaact tagccatggc   5820

agtaggcatg ggggaaaggc cagaggtatt gcatctcacg gagcccacta ctaacatctc   5880

aagggaaaag aaccaaggct tccaagatga aaccaagaaa ggaagcttag aggtggcaaa   5940

ccagactcct gggctacaga gggctttccc cgctccagca gcctgtcagt gccactgcaa   6000

acacatggag aggtggatgc atggcctcga gaatgatgaa tttgaaatcg agaaacccaa   6060

ggcttatatc ccagatctgt tcaaaagtaa aaccaatact atcgccatgg agggtgaacc   6120

cactgctatt ccatcacagc cgtttaaagt gaagcatgag cttttaaaag aaccttggaa   6180

agaaagtgca gaggggcaaa acgttttccc cacatatcct cttgaaggaa gtgagctcaa   6240

atcagaagac atggattttg agaataaaga tgattatgat agagacggaa actgccatag   6300

tcaagattat ccagggaagt actctgaaga ggagagcaag agctcaacat cgggcatcac   6360

aggagacatt ggggatgagc tacaggaggc tcgagctccc actattgctc agctgctaca   6420

ggagaaaact ctctattcct tctctgagtg gccaaaggac cgcgtgataa ttaaccgcct   6480

agataatatc tgccacgtgg tgttaaaggg gaagtggccc tctagccagc agtatgagcc   6540

ctcaggcaca ctgcccaccc cggtattaac cagcagtgct ggttctcgaa ccagcctctc   6600

agagccggaa gcagcagaac acagcttcag caacggcgca gcattggcgg cccagatcca   6660

caaggagagc ttcttagctc cagtattcac aaaggatgaa caaaagcaca ggcgtcccta   6720

tgagtttgag gtggagaggg atgcaaaggc tcggggcctg gagcagttct ctgccaccca   6780

cgggcacacc cctatcatcc tcaatggctg gcatggggag tcagctatgg acctctcctg   6840

ctcatcagag gggtccccag gagccacatc ccctttccca gtgagcgcca gcacccctaa   6900

gattggggct atcagttcac ttcagggagc ccttggcatg gacttgtctg ggattctgca   6960

agctggcctg atccatcctg tgactggaca gattgtcaat ggaagcctca gaagagatga   7020

tgcagccacg aggaggcgga gagggaggcg gaaacatgtt gaaggaggga tggacctcat   7080

ctttttgaag gagcagacac ttcaggcggg aatcttggaa gtccatgaag acccagggca   7140

ggccaccttg agcaccacac accctgaggg gccagggcct gccacctcgg ctcctgagcc   7200

agctacggca gccagcagcc aagccgagaa atccattccc agcaagagtc tgcttgactg   7260

gctaaggcag caggctgact actccttaga agttcctggc tttggggcaa atttttcaga   7320

caaaccaaag cagaggaggc cacgctgtaa agaacctgga aaattagatg tcagctccct   7380

gagcggggaa gagagagttc ctgccatccc caaggagcca ggactgaggg ggtttcttcc   7440

agaaaacaag ttcaatcaca ctctggctga gcctattctt cgagatacgg gcccccgcag   7500

gagggggagg cggcctcgga gcgaactcct gaaggctcct tccattgtgg cagactctcc   7560

ctctggaatg gggccactgt tcatgaatgg actgattgct gggatggacc tggtaggact   7620

tcagaacatg agaaatatgc caggcatccc cctcaccggg ctggtggggt ttccagctgg   7680

ctttgccacg atgccaacag gtgaagaggt caaaagtacc ctgagcatgc tgcccatgat   7740

gctgccaggc atggctgctg tgccccagat gtttggtgtt gggggactcc tcagtccacc   7800

catggcaacc acctgcactt ccactgctcc ggcgtctcta tcaagcacaa cgaaaagtgg   7860

tacggcagtg actgaaaaga ctgcggaaga caagccgagt agccatgatg tgaaaacaga   7920

cactttagct gaggacaagc ctggtccagg tccattttct gatcagtctg aacctgcaat   7980

aactactagt agtcctgtgg cttttaaccc atttctcatc ccaggagtat ctcctggact   8040

catttaccca tccatgttcc tctcccctgg tatgggcatg gctctgccag ccatgcagca   8100

ggccagacac tcggaaatag taggtctgga gagccagaag aggaagaaga agaagacaaa   8160

gggggacaac cccaactccc acccagagcc tg                                 8192


<210>  3919
<211>  2715
<212>  PRT
<213>  Homosapiens

<400>  3919

Met Lys Met Lys Ile Gln Lys Lys Glu Lys Gln Leu Ser Asn Leu Lys 
1               5                   10                  15      


Val Leu Asn His Ser Pro Met Ser Asp Ala Ser Val Asn Phe Asp Tyr 
            20                  25                  30          


Lys Ser Pro Ser Pro Phe Asp Cys Ser Thr Asp Gln Glu Glu Lys Ile 
        35                  40                  45              


Glu Asp Val Ala Ser His Cys Leu Pro Gln Lys Asp Leu Tyr Thr Ala 
    50                  55                  60                  


Glu Glu Glu Ala Ala Thr Leu Phe Pro Arg Lys Met Thr Ser His Asn 
65                  70                  75                  80  


Gly Met Glu Asp Ser Gly Gly Gly Gly Thr Gly Val Lys Lys Lys Arg 
                85                  90                  95      


Lys Lys Lys Glu Pro Gly Asp Gln Glu Gly Ala Ala Lys Gly Ser Lys 
            100                 105                 110         


Asp Arg Glu Pro Lys Pro Lys Arg Lys Arg Glu Pro Lys Glu Pro Lys 
        115                 120                 125             


Glu Pro Arg Lys Ala Lys Glu Pro Lys Lys Ala Lys Glu His Lys Glu 
    130                 135                 140                 


Pro Lys Gln Lys Asp Gly Ala Lys Lys Ala Arg Lys Pro Arg Glu Ala 
145                 150                 155                 160 


Ser Gly Thr Lys Glu Ala Lys Glu Lys Arg Ser Cys Thr Asp Ser Ala 
                165                 170                 175     


Ala Arg Thr Lys Ser Arg Lys Ala Ser Lys Glu Gln Gly Pro Thr Pro 
            180                 185                 190         


Val Glu Lys Lys Lys Lys Gly Lys Arg Lys Ser Glu Thr Thr Val Glu 
        195                 200                 205             


Ser Leu Glu Leu Asp Gln Gly Leu Thr Asn Pro Ser Leu Arg Ser Pro 
    210                 215                 220                 


Glu Glu Ser Thr Glu Ser Thr Asp Ser Gln Lys Arg Arg Ser Gly Arg 
225                 230                 235                 240 


Gln Val Lys Arg Arg Lys Tyr Asn Glu Asp Leu Asp Phe Lys Val Val 
                245                 250                 255     


Asp Asp Asp Gly Glu Thr Ile Ala Val Leu Gly Ala Gly Arg Thr Ser 
            260                 265                 270         


Ala Leu Ser Ala Ser Thr Leu Ala Trp Gln Ala Glu Glu Pro Pro Glu 
        275                 280                 285             


Asp Asp Ala Asn Ile Ile Glu Lys Ile Leu Ala Ser Lys Thr Val Gln 
    290                 295                 300                 


Glu Val His Pro Gly Glu Pro Pro Phe Asp Leu Glu Leu Phe Tyr Val 
305                 310                 315                 320 


Lys Tyr Arg Asn Phe Ser Tyr Leu His Cys Lys Trp Ala Thr Met Glu 
                325                 330                 335     


Glu Leu Glu Lys Asp Pro Arg Ile Ala Gln Lys Ile Lys Arg Phe Arg 
            340                 345                 350         


Asn Lys Gln Ala Gln Met Lys His Ile Phe Thr Glu Pro Asp Glu Asp 
        355                 360                 365             


Leu Phe Asn Pro Asp Tyr Val Glu Val Asp Arg Ile Leu Glu Val Ala 
    370                 375                 380                 


His Thr Lys Asp Ala Glu Thr Gly Glu Glu Val Thr His Tyr Leu Val 
385                 390                 395                 400 


Lys Trp Cys Ser Leu Pro Tyr Glu Glu Ser Thr Trp Glu Leu Glu Glu 
                405                 410                 415     


Asp Val Asp Pro Ala Lys Val Lys Glu Phe Glu Ser Leu Gln Val Leu 
            420                 425                 430         


Pro Glu Ile Lys His Val Glu Arg Pro Ala Ser Asp Ser Trp Gln Lys 
        435                 440                 445             


Leu Glu Lys Ser Arg Glu Tyr Lys Asn Ser Asn Gln Leu Arg Glu Tyr 
    450                 455                 460                 


Gln Leu Glu Gly Met Asn Trp Leu Leu Phe Asn Trp Tyr Asn Arg Lys 
465                 470                 475                 480 


Asn Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ser 
                485                 490                 495     


Ile Thr Phe Leu Ser Glu Ile Phe Leu Arg Gly Ile His Gly Pro Phe 
            500                 505                 510         


Leu Ile Ile Ala Pro Leu Ser Thr Ile Thr Asn Trp Glu Arg Glu Phe 
        515                 520                 525             


Arg Thr Trp Thr Glu Met Asn Ala Ile Val Tyr His Gly Ser Gln Ile 
    530                 535                 540                 


Ser Arg Gln Met Ile Gln Gln Tyr Glu Met Val Tyr Arg Asp Ala Gln 
545                 550                 555                 560 


Gly Asn Pro Leu Ser Gly Val Phe Lys Phe His Val Val Ile Thr Thr 
                565                 570                 575     


Phe Glu Met Ile Leu Ala Asp Cys Pro Glu Leu Lys Lys Ile His Trp 
            580                 585                 590         


Ser Cys Val Ile Ile Asp Glu Ala His Arg Leu Lys Asn Arg Asn Cys 
        595                 600                 605             


Lys Leu Leu Glu Gly Leu Lys Leu Met Ala Leu Glu His Lys Val Leu 
    610                 615                 620                 


Leu Thr Gly Thr Pro Leu Gln Asn Ser Val Glu Glu Leu Phe Ser Leu 
625                 630                 635                 640 


Leu Asn Phe Leu Glu Pro Ser Gln Phe Pro Ser Glu Thr Ala Phe Leu 
                645                 650                 655     


Glu Glu Phe Gly Asp Leu Lys Thr Glu Glu Gln Val Lys Lys Leu Gln 
            660                 665                 670         


Ser Ile Leu Lys Pro Met Met Leu Arg Arg Leu Lys Asp Asp Val Glu 
        675                 680                 685             


Lys Asn Leu Ala Pro Lys Gln Glu Thr Ile Ile Glu Val Glu Leu Thr 
    690                 695                 700                 


Asn Ile Gln Lys Lys Tyr Tyr Arg Ala Ile Leu Glu Lys Asn Phe Ser 
705                 710                 715                 720 


Phe Leu Thr Lys Gly Ala Asn Gln His Asn Met Pro Asn Leu Ile Asn 
                725                 730                 735     


Thr Met Met Glu Leu Arg Lys Cys Cys Asn His Pro Tyr Leu Ile Asn 
            740                 745                 750         


Gly Ala Glu Glu Lys Ile Leu Glu Asp Phe Arg Lys Thr His Ser Pro 
        755                 760                 765             


Asp Ala Pro Asp Phe Gln Leu Gln Ala Met Ile Gln Ala Ala Gly Lys 
    770                 775                 780                 


Leu Val Leu Ile Asp Lys Leu Leu Pro Lys Leu Ile Ala Gly Gly His 
785                 790                 795                 800 


Lys Val Leu Ile Phe Ser Gln Met Val Arg Cys Leu Asp Ile Leu Glu 
                805                 810                 815     


Asp Tyr Leu Ile Gln Arg Arg Tyr Thr Tyr Glu Arg Ile Asp Gly Arg 
            820                 825                 830         


Val Arg Gly Asn Leu Arg Gln Ala Ala Ile Asp Arg Phe Cys Lys Pro 
        835                 840                 845             


Asp Ser Asp Arg Phe Val Phe Leu Leu Cys Thr Arg Ala Gly Gly Leu 
    850                 855                 860                 


Gly Ile Asn Leu Thr Ala Ala Asp Thr Cys Ile Ile Phe Asp Ser Asp 
865                 870                 875                 880 


Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala Arg Cys His Arg Ile 
                885                 890                 895     


Gly Gln Ser Lys Ala Val Lys Val Tyr Arg Leu Ile Thr Arg Asn Ser 
            900                 905                 910         


Tyr Glu Arg Glu Met Phe Asp Lys Ala Ser Leu Lys Leu Gly Leu Asp 
        915                 920                 925             


Lys Ala Val Leu Gln Asp Ile Asn Arg Lys Gly Gly Thr Asn Gly Val 
    930                 935                 940                 


Gln Gln Leu Ser Lys Met Glu Val Glu Asp Leu Leu Arg Lys Gly Ala 
945                 950                 955                 960 


Tyr Gly Ala Leu Met Asp Glu Glu Asp Glu Gly Ser Lys Phe Cys Glu 
                965                 970                 975     


Glu Asp Ile Asp Gln Ile Leu Gln Arg Arg Thr His Thr Ile Thr Ile 
            980                 985                 990         


Gln Ser Glu Gly Lys Gly Ser Thr  Phe Ala Lys Ala Ser  Phe Val Ala 
        995                 1000                 1005             


Ser Gly  Asn Arg Thr Asp Ile  Ser Leu Asp Asp Pro  Asn Phe Trp 
    1010                 1015                 1020             


Gln Lys  Trp Ala Lys Ile Ala  Glu Leu Asp Thr Glu  Ala Lys Asn 
    1025                 1030                 1035             


Glu Lys  Glu Ser Leu Val Ile  Asp Arg Pro Arg Val  Arg Lys Gln 
    1040                 1045                 1050             


Thr Lys  His Tyr Asn Ser Phe  Glu Glu Asp Glu Leu  Met Glu Phe 
    1055                 1060                 1065             


Ser Glu  Leu Asp Ser Asp Ser  Asp Glu Arg Pro Thr  Arg Ser Arg 
    1070                 1075                 1080             


Arg Leu  Asn Asp Lys Ala Arg  Arg Tyr Leu Arg Ala  Glu Cys Phe 
    1085                 1090                 1095             


Arg Val  Glu Lys Asn Leu Leu  Ile Phe Gly Trp Gly  Arg Trp Lys 
    1100                 1105                 1110             


Asp Ile  Leu Thr His Gly Arg  Phe Lys Trp His Leu  Asn Glu Lys 
    1115                 1120                 1125             


Asp Met  Glu Met Ile Cys Arg  Ala Leu Leu Val Tyr  Cys Val Lys 
    1130                 1135                 1140             


His Tyr  Lys Gly Asp Glu Lys  Ile Lys Ser Phe Ile  Trp Glu Leu 
    1145                 1150                 1155             


Ile Thr  Pro Thr Lys Asp Gly  Gln Ala Gln Thr Leu  Gln Asn His 
    1160                 1165                 1170             


Ser Gly  Leu Ser Ala Pro Val  Pro Arg Gly Arg Lys  Gly Lys Lys 
    1175                 1180                 1185             


Thr Lys  Asn Gln Leu Leu Ile  Pro Glu Leu Lys Asp  Ala Asp Trp 
    1190                 1195                 1200             


Leu Ala  Thr Cys Asn Pro Glu  Val Val Leu His Asp  Asp Gly Tyr 
    1205                 1210                 1215             


Lys Lys  His Leu Lys Gln His  Cys Asn Lys Val Leu  Leu Arg Val 
    1220                 1225                 1230             


Arg Met  Leu Tyr Tyr Leu Lys  Ala Glu Ile Leu Gly  Glu Ala Ala 
    1235                 1240                 1245             


Glu Lys  Ala Phe Glu Gly Ser  Pro Ala Arg Glu Leu  Asp Val Pro 
    1250                 1255                 1260             


Leu Pro  Asp Ile Asp Tyr Met  Glu Ile Pro Val Asp  Trp Trp Asp 
    1265                 1270                 1275             


Ala Glu  Ala Asp Lys Ser Leu  Leu Ile Gly Val Phe  Lys His Gly 
    1280                 1285                 1290             


Tyr Glu  Arg Tyr Asn Ala Met  Arg Ala Asp Pro Ala  Leu Cys Phe 
    1295                 1300                 1305             


Leu Glu  Lys Val Gly Met Pro  Asp Glu Lys Ser Leu  Ser Ala Glu 
    1310                 1315                 1320             


Gln Gly  Val Thr Asp Gly Thr  Ser Asp Ile Pro Glu  Arg Gly Asn 
    1325                 1330                 1335             


Thr Asp  Lys Glu Asp Asn Ala  Glu Asp Lys Val Asp  Gly Leu Gln 
    1340                 1345                 1350             


Lys Gln  Thr Glu Ser Ser Ser  Asp Gly Gly Asp Gly  Val Phe Ser 
    1355                 1360                 1365             


Glu Lys  Lys Asp Asp Ser Arg  Ala Ala Gln Asp Gly  Ser Asp Pro 
    1370                 1375                 1380             


Asp Lys  Ser Pro Trp Pro Val  Ser Ser Ala Leu Thr  Ala Arg Leu 
    1385                 1390                 1395             


Arg Arg  Leu Val Thr Val Tyr  Gln Arg Cys Asn Arg  Lys Glu Leu 
    1400                 1405                 1410             


Cys Arg  Pro Glu Ile Leu Gly  Pro Gly Asn Gln Gly  Tyr Trp Val 
    1415                 1420                 1425             


Gln Glu  Glu Met Phe Arg Arg  Thr Ser Glu Met Asp  Leu Ile Asn 
    1430                 1435                 1440             


Lys Glu  Ala Gln Lys Arg Trp  Thr Arg Arg Glu Gln  Ala Asp Phe 
    1445                 1450                 1455             


Tyr Arg  Thr Val Ser Ser Phe  Gly Val Val Tyr Asp  Gln Glu Lys 
    1460                 1465                 1470             


Lys Thr  Phe Asp Trp Thr Gln  Phe Arg Ile Ile Ser  Arg Leu Asp 
    1475                 1480                 1485             


Lys Lys  Ser Asp Glu Ser Leu  Glu Gln Tyr Phe Tyr  Ser Phe Val 
    1490                 1495                 1500             


Ala Met  Cys Arg Asn Val Cys  Arg Leu Pro Thr Trp  Lys Asp Gly 
    1505                 1510                 1515             


Gly Pro  Pro Asp Thr Thr Ile  Tyr Val Glu Pro Ile  Thr Glu Glu 
    1520                 1525                 1530             


Arg Ala  Ala Arg Thr Leu Tyr  Arg Ile Glu Leu Leu  Arg Lys Val 
    1535                 1540                 1545             


Arg Glu  Gln Val Leu Lys Cys  Pro Gln Leu His Glu  Arg Leu Gln 
    1550                 1555                 1560             


Leu Cys  Arg Pro Ser Leu Tyr  Leu Pro Val Trp Trp  Glu Cys Gly 
    1565                 1570                 1575             


Lys His  Asp Arg Asp Leu Leu  Ile Gly Thr Ala Lys  His Gly Leu 
    1580                 1585                 1590             


Asn Arg  Thr Asp Cys Tyr Ile  Met Asn Asp Pro Gln  Leu Ser Phe 
    1595                 1600                 1605             


Leu Asp  Ala Tyr Arg Asn Tyr  Ala Gln His Lys Arg  Ser Gly Thr 
    1610                 1615                 1620             


Gln Ala  Pro Gly Asn Leu Cys  Cys Leu Tyr Gln Thr  Asn Ser Lys 
    1625                 1630                 1635             


Leu Tyr  Glu Ser Leu Thr Tyr  Ser Gln Met Ser Arg  Thr Ser Glu 
    1640                 1645                 1650             


Ser Leu  Glu Asn Glu Pro Glu  Asn Leu Val Arg Val  Glu Ser Arg 
    1655                 1660                 1665             


Asp Asp  His Leu Ser Leu Pro  Asp Val Thr Cys Glu  Asn Phe Ile 
    1670                 1675                 1680             


Ser Lys  Val Gln Asp Val Ile  Ser Ile Asn His Asp  Glu Ser Leu 
    1685                 1690                 1695             


Leu Pro  Glu Ser Leu Glu Ser  Met Met Tyr Gly Lys  Lys Val Leu 
    1700                 1705                 1710             


Ser Gln  Glu Pro Ser Ser Phe  Gln Glu Ser Pro Ser  Thr Asn Thr 
    1715                 1720                 1725             


Glu Ser  Arg Lys Asp Val Ile  Thr Ile Ser Ile Ser  Lys Asp Gly 
    1730                 1735                 1740             


Asn Cys  Gln Ser Gly Gly Pro  Glu Ala Glu Ile Ala  Ser Gly Pro 
    1745                 1750                 1755             


Thr Phe  Met Gly Ser Leu Glu  Ala Gly Gly Val Ala  Gln Ala Asn 
    1760                 1765                 1770             


Ile Lys  Asn Gly Lys His Leu  Leu Met Ser Ile Ser  Lys Glu Gly 
    1775                 1780                 1785             


Glu Leu  Cys Cys Ser Glu Ala  Gly Gln Arg Pro Glu  Asn Ile Gly 
    1790                 1795                 1800             


Gln Leu  Glu Ala Lys Cys Leu  Ala Ser Pro Ser Leu  Asn Pro Gly 
    1805                 1810                 1815             


Asn Glu  Ser Gly Phe Val Asp  Met Cys Ser Leu Ser  Val Cys Asp 
    1820                 1825                 1830             


Ser Lys  Arg Asn Leu Ser Ser  Asp Gln Gln Leu Ile  Asp Leu Leu 
    1835                 1840                 1845             


Glu Asn  Lys Ser Leu Glu Ser  Lys Leu Ile Leu Ser  Gln Asn His 
    1850                 1855                 1860             


Ser Asp  Glu Glu Glu Glu Glu  Glu Glu Asn Glu Glu  Glu Asn Leu 
    1865                 1870                 1875             


Ala Met  Ala Val Gly Met Gly  Glu Arg Pro Glu Val  Leu His Leu 
    1880                 1885                 1890             


Thr Glu  Pro Thr Thr Asn Ile  Ser Arg Glu Lys Asn  Gln Gly Phe 
    1895                 1900                 1905             


Gln Asp  Glu Thr Lys Lys Gly  Ser Leu Glu Val Ala  Asn Gln Thr 
    1910                 1915                 1920             


Pro Gly  Leu Gln Arg Ala Phe  Pro Ala Pro Ala Ala  Cys Gln Cys 
    1925                 1930                 1935             


His Cys  Lys His Met Glu Arg  Trp Met His Gly Leu  Glu Asn Asp 
    1940                 1945                 1950             


Glu Phe  Glu Ile Glu Lys Pro  Lys Ala Tyr Ile Pro  Asp Leu Phe 
    1955                 1960                 1965             


Lys Ser  Lys Thr Asn Thr Ile  Ala Met Glu Gly Glu  Pro Thr Ala 
    1970                 1975                 1980             


Ile Pro  Ser Gln Pro Phe Lys  Val Lys His Glu Leu  Leu Lys Glu 
    1985                 1990                 1995             


Pro Trp  Lys Glu Ser Ala Glu  Gly Gln Asn Val Phe  Pro Thr Tyr 
    2000                 2005                 2010             


Pro Leu  Glu Gly Ser Glu Leu  Lys Ser Glu Asp Met  Asp Phe Glu 
    2015                 2020                 2025             


Asn Lys  Asp Asp Tyr Asp Arg  Asp Gly Asn Cys His  Ser Gln Asp 
    2030                 2035                 2040             


Tyr Pro  Gly Lys Tyr Ser Glu  Glu Glu Ser Lys Ser  Ser Thr Ser 
    2045                 2050                 2055             


Gly Ile  Thr Gly Asp Ile Gly  Asp Glu Leu Gln Glu  Ala Arg Ala 
    2060                 2065                 2070             


Pro Thr  Ile Ala Gln Leu Leu  Gln Glu Lys Thr Leu  Tyr Ser Phe 
    2075                 2080                 2085             


Ser Glu  Trp Pro Lys Asp Arg  Val Ile Ile Asn Arg  Leu Asp Asn 
    2090                 2095                 2100             


Ile Cys  His Val Val Leu Lys  Gly Lys Trp Pro Ser  Ser Gln Gln 
    2105                 2110                 2115             


Tyr Glu  Pro Ser Gly Thr Leu  Pro Thr Pro Val Leu  Thr Ser Ser 
    2120                 2125                 2130             


Ala Gly  Ser Arg Thr Ser Leu  Ser Glu Pro Glu Ala  Ala Glu His 
    2135                 2140                 2145             


Ser Phe  Ser Asn Gly Ala Ala  Leu Ala Ala Gln Ile  His Lys Glu 
    2150                 2155                 2160             


Ser Phe  Leu Ala Pro Val Phe  Thr Lys Asp Glu Gln  Lys His Arg 
    2165                 2170                 2175             


Arg Pro  Tyr Glu Phe Glu Val  Glu Arg Asp Ala Lys  Ala Arg Gly 
    2180                 2185                 2190             


Leu Glu  Gln Phe Ser Ala Thr  His Gly His Thr Pro  Ile Ile Leu 
    2195                 2200                 2205             


Asn Gly  Trp His Gly Glu Ser  Ala Met Asp Leu Ser  Cys Ser Ser 
    2210                 2215                 2220             


Glu Gly  Ser Pro Gly Ala Thr  Ser Pro Phe Pro Val  Ser Ala Ser 
    2225                 2230                 2235             


Thr Pro  Lys Ile Gly Ala Ile  Ser Ser Leu Gln Gly  Ala Leu Gly 
    2240                 2245                 2250             


Met Asp  Leu Ser Gly Ile Leu  Gln Ala Gly Leu Ile  His Pro Val 
    2255                 2260                 2265             


Thr Gly  Gln Ile Val Asn Gly  Ser Leu Arg Arg Asp  Asp Ala Ala 
    2270                 2275                 2280             


Thr Arg  Arg Arg Arg Gly Arg  Arg Lys His Val Glu  Gly Gly Met 
    2285                 2290                 2295             


Asp Leu  Ile Phe Leu Lys Glu  Gln Thr Leu Gln Ala  Gly Ile Leu 
    2300                 2305                 2310             


Glu Val  His Glu Asp Pro Gly  Gln Ala Thr Leu Ser  Thr Thr His 
    2315                 2320                 2325             


Pro Glu  Gly Pro Gly Pro Ala  Thr Ser Ala Pro Glu  Pro Ala Thr 
    2330                 2335                 2340             


Ala Ala  Ser Ser Gln Ala Glu  Lys Ser Ile Pro Ser  Lys Ser Leu 
    2345                 2350                 2355             


Leu Asp  Trp Leu Arg Gln Gln  Ala Asp Tyr Ser Leu  Glu Val Pro 
    2360                 2365                 2370             


Gly Phe  Gly Ala Asn Phe Ser  Asp Lys Pro Lys Gln  Arg Arg Pro 
    2375                 2380                 2385             


Arg Cys  Lys Glu Pro Gly Lys  Leu Asp Val Ser Ser  Leu Ser Gly 
    2390                 2395                 2400             


Glu Glu  Arg Val Pro Ala Ile  Pro Lys Glu Pro Gly  Leu Arg Gly 
    2405                 2410                 2415             


Phe Leu  Pro Glu Asn Lys Phe  Asn His Thr Leu Ala  Glu Pro Ile 
    2420                 2425                 2430             


Leu Arg  Asp Thr Gly Pro Arg  Arg Arg Gly Arg Arg  Pro Arg Ser 
    2435                 2440                 2445             


Glu Leu  Leu Lys Ala Pro Ser  Ile Val Ala Asp Ser  Pro Ser Gly 
    2450                 2455                 2460             


Met Gly  Pro Leu Phe Met Asn  Gly Leu Ile Ala Gly  Met Asp Leu 
    2465                 2470                 2475             


Val Gly  Leu Gln Asn Met Arg  Asn Met Pro Gly Ile  Pro Leu Thr 
    2480                 2485                 2490             


Gly Leu  Val Gly Phe Pro Ala  Gly Phe Ala Thr Met  Pro Thr Gly 
    2495                 2500                 2505             


Glu Glu  Val Lys Ser Thr Leu  Ser Met Leu Pro Met  Met Leu Pro 
    2510                 2515                 2520             


Gly Met  Ala Ala Val Pro Gln  Met Phe Gly Val Gly  Gly Leu Leu 
    2525                 2530                 2535             


Ser Pro  Pro Met Ala Thr Thr  Cys Thr Ser Thr Ala  Pro Ala Ser 
    2540                 2545                 2550             


Leu Ser  Ser Thr Thr Lys Ser  Gly Thr Ala Val Thr  Glu Lys Thr 
    2555                 2560                 2565             


Ala Glu  Asp Lys Pro Ser Ser  His Asp Val Lys Thr  Asp Thr Leu 
    2570                 2575                 2580             


Ala Glu  Asp Lys Pro Gly Pro  Gly Pro Phe Ser Asp  Gln Ser Glu 
    2585                 2590                 2595             


Pro Ala  Ile Thr Thr Ser Ser  Pro Val Ala Phe Asn  Pro Phe Leu 
    2600                 2605                 2610             


Ile Pro  Gly Val Ser Pro Gly  Leu Ile Tyr Pro Ser  Met Phe Leu 
    2615                 2620                 2625             


Ser Pro  Gly Met Gly Met Ala  Leu Pro Ala Met Gln  Gln Ala Arg 
    2630                 2635                 2640             


His Ser  Glu Ile Val Gly Leu  Glu Ser Gln Lys Arg  Lys Lys Lys 
    2645                 2650                 2655             


Lys Thr  Lys Gly Asp Asn Pro  Asn Ser His Pro Glu  Pro Ala Pro 
    2660                 2665                 2670             


Ser Cys  Glu Arg Glu Pro Ser  Gly Asp Glu Asn Cys  Ala Glu Pro 
    2675                 2680                 2685             


Ser Ala  Pro Leu Pro Ala Glu  Arg Glu His Gly Ala  Gln Ala Gly 
    2690                 2695                 2700             


Glu Gly  Ala Leu Lys Asp Ser  Asn Asn Asp Thr Asn  
    2705                 2710                 2715 


<210>  3920
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3920
cctcccgcct cagttcgcgc cgcgcctcgg cttggaacgc aggagcgccg gctccgggag     60

cccgagcgga gccagccgcg cgcacagcca gcggccgcgc cggcgatgcg gggccacccc    120

gcgcccgccc cagtcccggc cccggccccc gcgggaaggg gctgagctgc ccgccgccgc    180

ccggatggcg agcctcgccg cgctcgccct cagcctgctc ctgaggctgc agctgccgcc    240

actgcccggc gcccgggctc agagcgcccc aggtggctgt tcctttgatg agcactacag    300

caactgtggt tatagtgtgg ctctagggac caatgggttc acctgggagc agattaacac    360

atgggagaaa ccaatgctgg accaggcagt gcccacagga tctttcatga tggtgaacag    420

ctctgggaga gcctctggcc agaaggccca ccttctcctg ccaaccctga aggagaatga    480

cacccactgc atcgacttcc attactactt ctccagccgt gacaggtcca gcccaggggc    540

cttgaacgtc tacgtgaagg tgaatggtgg cccccaaggg aaccctgtgt ggaatgtgtc    600

cggggtcgtc actgagggct gggtgaaggc agagctcgcc atcagcactt tctggccaca    660

tttctatcag gtgatatttg aatccgtctc attgaagggt catcctggct acatcgccgt    720

ggacgaggtc cgggtccttg ctcatccatg cagaaaagca cctcattttc tgcgactcca    780

aaacgtggag gtgaatgtgg ggcagaatgc cacatttcag tgcattgctg gtgggaagtg    840

gtctcagcat gacaagcttt ggctccagca atggaatggc agggacacgg ccctgatggt    900

cacccgtgtg gtcaaccaca ggcgcttctc agccacagtc agtgtggcag acactgccca    960

gcggagcgtc agcaagtacc gctgtgtgat ccgctctgat ggtgggtctg gtgtgtccaa   1020

ctacgcggag ctgatcgtga aagagcctcc cacgcccatt gctcccccag agctgctggc   1080

tgtgggggcc acatacctgt ggatcaagcc aaatgccaac tccatcatcg gggatggccc   1140

catcatcctg aaggaagtgg aatatcgcac caccacaggc acgtgggcag agacccacat   1200

agtcgactct cccaactata agctgtggca tctggacccc gatgttgagt atgagatccg   1260

agtgctcctc acacgaccag gtgagggggg tacgggaccg ccagggcctc ccctcaccac   1320

caggaccaag tgtgcagatc cggtacatgg cccacagaac gtggaaatcg tagacatcag   1380

agcccggcag ctgaccctgc agtgggagcc cttcggctac gcggtgaccc gctgccatag   1440

ctacaacctc accgtgcagt accagtatgt gttcaaccag cagcagtacg aggccgagga   1500

ggtcatccag acctcctccc actacaccct gcgaggcctg cgccccttca tgaccatccg   1560

gctgcgactc ttgctgtcta accccgaggg ccgaatggag agcgaggagc tggtggtgca   1620

gactgaggaa gacgttccag gagctgttcc tctagaatcc atccaagggg ggccctttga   1680

ggagaagatc tacatccagt ggaaacctcc caatgagacc aatggggtca tcacgctcta   1740

cgagatcaac tacaaggctg tcggctcgct ggacccaagt gctgacctct cgagccagag   1800

ggggaaagtg ttcaagctcc ggaatgaaac ccaccacctc tttgtgggtc tgtacccagg   1860

gaccacctat tccttcacca tcaaggccag cacagcaaag ggctttgggc cccctgtcac   1920

cactcggatt gccaccaaaa tttcagctcc atccatgcct gagtacgaca cagacacccc   1980

attgaatgag acagacacga ccatcacagt gatgctgaaa cccgctcagt cccggggagc   2040

tcctgtcagt gtttatcagc tggttgtcaa ggaggagcga cttcagaagt cacggagggc   2100

agctgacatt attgagtgct tttcggtgcc cgtgagctat cggaatgcct ccagcctcga   2160

ttctctacac tactttgctg ctgagttgaa gcctgccaac ctgcctgtca cccagccatt   2220

tacagtgggt gacaataaga catacaatgg ctactggaac cctcctctct ctcccctgaa   2280

aagctacagc atctacttcc aggcactcag caaagccaat ggagagacca aaatcaactg   2340

tgttcgtctg gctacaaaag gtgcctccac ccagaattct aacactgtgg agccagagaa   2400

gcaggtggac aacaccgtga agatggctgg cgtgatcgct ggcctcctca tgttcatcat   2460

cattctcctg ggcgtgatgc tcaccatcaa aaggagaaga aatgcttatt cctactccta   2520

ttacttgtcc caaaggaagc tggccaagaa gcagaaggag acccagagtg gagcccagag   2580

ggagatgggg cctgtggcct ctgccgacaa acccaccacc aagctcagcg ccagccgcaa   2640

tgatgaaggc ttctcttcta gttctcagga cgtcaacgga ttcacagatg gcagccgcgg   2700

ggagctttcc cagcccaccc tcacgatcca gactcatccc taccgcacct gtgaccctgt   2760

ggagatgagc tacccccggg accagttcca acccgccatc cgggtggctg acttgctgca   2820

gcacatcacg cagatgaaga gaggccaggg ctacgggttc aaggaggaat acgaggcctt   2880

accagagggg cagacagctt cgtgggacac agccaaggag gatgaaaacc gcaataagaa   2940

tcgatatggg aacatcatat cctacgacca ttcccgggtg aggctgctgg tgctggatgg   3000

agacccgcac tctgactaca tcaatgccaa ctacattgac ggataccatc gacctcggca   3060

ctacattgcg actcaaggtc cgatgcagga gactgtaaag gacttttgga gaatgatctg   3120

gcaggagaac tccgccagca tcgtcatggt cacaaacctg gtggaagtgg gcagggtgaa   3180

atgtgtgcga tactggccag atgacacgga ggtctacgga gacattaaag tcaccctgat   3240

tgaaacagag cccctggcag aatacgtcat acgcaccttc acagtccaga agaaaggcta   3300

ccatgagatc cgggagctcc gcctcttcca cttcaccagc tggcctgacc acggcgttcc   3360

ctgctatgcc actggccttc tgggcttcgt ccgccaggtc aagttcctca accccccgga   3420

agctgggccc atagtggtcc actgcagtgc tggggctggg cggactggct gcttcattgc   3480

cattgacacc atgcttgaca tggccgagaa tgaaggggtg gtggacatct tcaactgcgt   3540

gcgtgagctc cgggcccaaa gggtcaacct ggtacagaca gaggagcaat atgtgtttgt   3600

gcacgatgcc atcctggaag cgtgcctctg tggcaacact gccatccctg tgtgtgagtt   3660

ccgttctctc tactacaata tcagcaggct ggacccccag acaaactcca gccaaatcaa   3720

agatgaattt cagaccctca acattgtgac accccgtgtg cggcccgagg actgcagcat   3780

tgggctcctg ccccggaacc atgataagaa tcgaagtatg gacgtgctgc ctctggaccg   3840

ctgcctgccc ttccttatct cagtggacgg agaatccagc aattacatca acgcagcact   3900

gatggatagc cacaagcagc ctgccgcctt cgtggtcacc cagcaccctc tacccaacac   3960

cgtggcagac ttctggaggc tggtgttcga ttacaactgc tcctctgtgg tgatgctgaa   4020

tgagatggac actgcccagt tctgtatgca gtactggcct gagaagacct ccgggtgcta   4080

tgggcccatc caggtggagt tcgtctccgc agacatcgac gaggacatca tccacagaat   4140

attccgcatc tgtaacatgg cccggccaca ggatggttat cgtatagtcc agcacctcca   4200

gtacattggc tggcctgcct accgggacac gcccccctcc aagcgctctc tgctcaaagt   4260

ggtccgacga ctggagaagt ggcaggagca gtatgacggg agggagggac gtactgtggt   4320

ccactgccta aatgggggag gccgtagtgg aaccttctgt gccatctgca gtgtgtgtga   4380

gatgatccag cagcaaaaca tcattgacgt gttccacatc gtgaaaacac tgcgtaacaa   4440

caaatccaac atggtggaga ccctggaaca gtataaattt gtatacgagg tggcactgga   4500

atatttaagc tccttttagc tcaatgggat ggggaacctg ccggagtcca gaggctgctg   4560

tgaccaagcc cccttttgtg tgaatggcag taactgggct caggagctct gaggtggcac   4620

cctgcctgac tccaaggaga agactggtgg ccctgtgttc cacggggggc tctgcacctt   4680

ctgaggggtc tcctgttgcc gtgggagatg ctgctccaaa aggcccaggc ttccttttca   4740

acctaaccag ccacagccaa gggcccaagc agaagtacac ccacaagcaa ggccttggat   4800

ttctggctcc cagaccacct gcttttgttc tgagtttgtg gatctcttgg caagccaact   4860

gtgcaggtgc tggggagtgg gaggctcccc tgccctcctt ctccttagga gtggaggaga   4920

tgtgtgttct gctcctctac gtcatggaaa agattgaggc tcttgggggt cactgctctg   4980

ctgccccctg caacctcctt caggggcctc tggcaccaga catttgcagt ctggaccagt   5040

gtgaccttac gatgttccct aggccacaag agaggccccc catcctcaca cctaacctgc   5100

atggggcttc gcccacaacc attctgtacc ccttccccag cctgggcctt gaccgtccag   5160

cattcactgg ccggccagct gtgtccacag cagtttttga taaaggtgtt ctttgctttt   5220

ttgtgtggtc agtgggaggg ggtggaactg cagggaactt ctctgctcct ccttgtcttt   5280

gtaaaaaggg accacctccc tggggcaggg cttgggctga cctgtaggat gtaacccctg   5340

tgtttctttg gtggtagctt tctttggaag agacaaacaa gataagattt gattattttc   5400

caaagtgtat gtgaaaagaa actttctttt ggagggtgta aaatcttagt ctcttatgtc   5460

aaaaagaagg gggcggggga gtttgagtat gtacctctaa gacaaatctc tcgggccttt   5520

tattttttcc tggcaatgtc cttaaaagct cccaccctgg gacagcatgc cactgagcaa   5580

ggagagatgg gtgagcctga agatggtccc tttggtttct ggggcaaata gagcaccagc   5640

tttgtgcata atttggatgt ccaaatttga actccttcct aaagaaaccc agcagccacc   5700

ttgaaaaagg ccattgtgga gcccattata ctttgattta aaataggcca agagaatcag   5760

gcctggagat ctagggtctt gtccaaagtg tgagtgagtc aatgagaggg aaccaacatt   5820

tgctaagtct ctactgtatg ccagggatca tgcttggcac tttccatagg acatttcaca   5880

cagtccttag aacccccagg agagagctac tgacttgtta tcatctccat ttgatcatct   5940

cctccaatga ggaaacccac gcaccttcct tagtaatgaa atcctgggtt ccaaaggggc   6000

aggtaatggc aatgagactt ctccgtgctg ttttcttcat cttctctaag ccaagcaatt   6060

attttatgga gggaaaataa ggccagaaac ttctgagcag ataactccac aaatggaaat   6120

ttagtacttt cttcctgatg ccagttcttc tgggaagcgc agaatttcag atatatttta   6180

gtaacacatt cccagctccc caggaaagcc agtctcatct aatttcttag tcagtaaaaa   6240

caattccctg ttccttcagg ctatgaatgg accagccagg gaaactctcg accttgatct   6300

ctagccagtg cttaggccca atatctgaca gcctcaggtg ggctgggacc taggaagctc   6360

catcttgaag gctggtctag ccccagacag ggcatgaggg gcagagaatt caagaaggta   6420

cagctttggc cctcaagagc ccactgtatg ctggggaaat ggaaccatgg tgcagtagtg   6480

tggagtggat gagtgttcca tgagcctagg agcaagaaag tctcttcggc ctcgggcttc   6540

ctggagaagg ggacgtccat tcctgctggg tcttaacaag cataaaaagg aaaaaaagga   6600

aactcaggca aagggatcca tatgtgcaat ggcaaagaaa tgtgaaaagg cattgggaga   6660

agcagtctgg gggaggccag cccagtgcgg gcacagcaca acacggggag cagcaagaga   6720

tgagccaggg tccaggagac agatgcccat cgcgagtaca gactttgtcc tattggcaac   6780

aaggagtcca tggagcttta gagagatgca ctcagcttcg tgttggccaa gactccttct   6840

gggccaatgg ggctgcctct tttcctttca tcagacactg tgaaaacatt cccttaagcg   6900

tgcacttttt aatatcacat ctatttgtct gtctgctcat tgttttgttg ctggaactaa   6960

atatgcaatg gatcatgaga ctcagattct atgagaaacc cagggtctct gctttaccac   7020

ggagcagggt caccaaccca gatctccagg cccatgagga tggaacatga aaggagccga   7080

caaaagttgc ttccattggc atgggctctg gagctgtcca gaagtccagg gacaccagac   7140

ttgatcaagg aagggctgtc actttagagg ttcaaaagga agtgcctcaa agcaaaggca   7200

agcaaaggaa ccccacgatg aacttgctct tttcctttga tgagcctctc cccaggtgta   7260

tttcagcaga ccccggggac ccacccccac tgggcctgct ggcctccctc ggctccagcc   7320

caatgcccca gctggccttc cccagcctgc aaggagcctg tagcatggca aatctgcctg   7380

ctgtatgcta ttttcttaga tcttggtaca tccagacagg atgagggtgg agggagagct   7440

atttaacaca aatcctaaga tttttttctg ctcaggaagg ggtgaaatag ctggcagata   7500

caaaagacag tggcttttat cattttaaat ggtaggaatt taaggtgtga cttcagggag   7560

aaacaaactt gcaaaaaaaa aaaatctcag gccatgttgg ggtaacccag caagggccag   7620

tgatgatttc ccccagctca tccccttatt ttcccacaac ccaaccattc tctaaagcag   7680

gacagtgaat aggtcttagg ccagtgcaca caggaagaaa ttgaggctta tggatgggga   7740

tgacttccct aagatcccat gggacaagga tgtggcaagg cttggatgag atggggcacc   7800

agtgcccagg aatttgaaca ttttccttta cccaggaaat ctccggagcc aacaccacca   7860

cccccagggg gtctccccac cccaccccat ttacagggtg agctcagcct gtcatgagca   7920

gaggaaaata ttattaatgc tctctgagtc tttacaacag gagctcttac ctcatagatg   7980

tgggctctgt ttggggaaga tgcaaggaag taatgagaag cccaggaaat ttctccacct   8040

gtgtttatgg cctaaatagc ttcaggatgt atcttagctg cactccaaca ttgcatcctt   8100

tctggggtga agaatctggg ccaaccaggg gtccttgggc ctctagaagg ccacagtagg   8160

cctctctttg tgggaatgga aggggacagt tt                                 8192


<210>  3921
<211>  1444
<212>  PRT
<213>  Homosapiens

<400>  3921

Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln 
1               5                   10                  15      


Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Pro Gly Gly Cys 
            20                  25                  30          


Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly 
        35                  40                  45              


Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Trp Glu Lys Pro Met 
    50                  55                  60                  


Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser 
65                  70                  75                  80  


Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys 
                85                  90                  95      


Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg 
            100                 105                 110         


Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly 
        115                 120                 125             


Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu 
    130                 135                 140                 


Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe 
145                 150                 155                 160 


Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr 
                165                 170                 175     


Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala 
            180                 185                 190         


Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn 
        195                 200                 205             


Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys 
    210                 215                 220                 


Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr 
225                 230                 235                 240 


Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp 
                245                 250                 255     


Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp 
            260                 265                 270         


Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro 
        275                 280                 285             


Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr 
    290                 295                 300                 


Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile 
305                 310                 315                 320 


Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu 
                325                 330                 335     


Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro 
            340                 345                 350         


Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly 
        355                 360                 365             


Gly Thr Gly Pro Pro Gly Pro Pro Leu Thr Thr Arg Thr Lys Cys Ala 
    370                 375                 380                 


Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala 
385                 390                 395                 400 


Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg 
                405                 410                 415     


Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln 
            420                 425                 430         


Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr 
        435                 440                 445             


Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu 
    450                 455                 460                 


Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr 
465                 470                 475                 480 


Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly 
                485                 490                 495     


Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr 
            500                 505                 510         


Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser 
        515                 520                 525             


Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys 
    530                 535                 540                 


Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr 
545                 550                 555                 560 


Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro 
                565                 570                 575     


Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro 
            580                 585                 590         


Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr 
        595                 600                 605             


Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr 
    610                 615                 620                 


Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala 
625                 630                 635                 640 


Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser 
                645                 650                 655     


Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn 
            660                 665                 670         


Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn 
        675                 680                 685             


Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr 
    690                 695                 700                 


Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val 
705                 710                 715                 720 


Arg Leu Ala Thr Lys Gly Ala Ser Thr Gln Asn Ser Asn Thr Val Glu 
                725                 730                 735     


Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly Val Ile Ala 
            740                 745                 750         


Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met Leu Thr Ile 
        755                 760                 765             


Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu Ser Gln Arg 
    770                 775                 780                 


Lys Leu Ala Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala Gln Arg Glu 
785                 790                 795                 800 


Met Gly Pro Val Ala Ser Ala Asp Lys Pro Thr Thr Lys Leu Ser Ala 
                805                 810                 815     


Ser Arg Asn Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp Val Asn Gly 
            820                 825                 830         


Phe Thr Asp Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr Leu Thr Ile 
        835                 840                 845             


Gln Thr His Pro Tyr Arg Thr Cys Asp Pro Val Glu Met Ser Tyr Pro 
    850                 855                 860                 


Arg Asp Gln Phe Gln Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His 
865                 870                 875                 880 


Ile Thr Gln Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys Glu Glu Tyr 
                885                 890                 895     


Glu Ala Leu Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr Ala Lys Glu 
            900                 905                 910         


Asp Glu Asn Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile Ser Tyr Asp 
        915                 920                 925             


His Ser Arg Val Arg Leu Leu Val Leu Asp Gly Asp Pro His Ser Asp 
    930                 935                 940                 


Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro Arg His Tyr 
945                 950                 955                 960 


Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Val Lys Asp Phe Trp Arg 
                965                 970                 975     


Met Ile Trp Gln Glu Asn Ser Ala Ser Ile Val Met Val Thr Asn Leu 
            980                 985                 990         


Val Glu Val Gly Arg Val Lys Cys  Val Arg Tyr Trp Pro  Asp Asp Thr 
        995                 1000                 1005             


Glu Val  Tyr Gly Asp Ile Lys  Val Thr Leu Ile Glu  Thr Glu Pro 
    1010                 1015                 1020             


Leu Ala  Glu Tyr Val Ile Arg  Thr Phe Thr Val Gln  Lys Lys Gly 
    1025                 1030                 1035             


Tyr His  Glu Ile Arg Glu Leu  Arg Leu Phe His Phe  Thr Ser Trp 
    1040                 1045                 1050             


Pro Asp  His Gly Val Pro Cys  Tyr Ala Thr Gly Leu  Leu Gly Phe 
    1055                 1060                 1065             


Val Arg  Gln Val Lys Phe Leu  Asn Pro Pro Glu Ala  Gly Pro Ile 
    1070                 1075                 1080             


Val Val  His Cys Ser Ala Gly  Ala Gly Arg Thr Gly  Cys Phe Ile 
    1085                 1090                 1095             


Ala Ile  Asp Thr Met Leu Asp  Met Ala Glu Asn Glu  Gly Val Val 
    1100                 1105                 1110             


Asp Ile  Phe Asn Cys Val Arg  Glu Leu Arg Ala Gln  Arg Val Asn 
    1115                 1120                 1125             


Leu Val  Gln Thr Glu Glu Gln  Tyr Val Phe Val His  Asp Ala Ile 
    1130                 1135                 1140             


Leu Glu  Ala Cys Leu Cys Gly  Asn Thr Ala Ile Pro  Val Cys Glu 
    1145                 1150                 1155             


Phe Arg  Ser Leu Tyr Tyr Asn  Ile Ser Arg Leu Asp  Pro Gln Thr 
    1160                 1165                 1170             


Asn Ser  Ser Gln Ile Lys Asp  Glu Phe Gln Thr Leu  Asn Ile Val 
    1175                 1180                 1185             


Thr Pro  Arg Val Arg Pro Glu  Asp Cys Ser Ile Gly  Leu Leu Pro 
    1190                 1195                 1200             


Arg Asn  His Asp Lys Asn Arg  Ser Met Asp Val Leu  Pro Leu Asp 
    1205                 1210                 1215             


Arg Cys  Leu Pro Phe Leu Ile  Ser Val Asp Gly Glu  Ser Ser Asn 
    1220                 1225                 1230             


Tyr Ile  Asn Ala Ala Leu Met  Asp Ser His Lys Gln  Pro Ala Ala 
    1235                 1240                 1245             


Phe Val  Val Thr Gln His Pro  Leu Pro Asn Thr Val  Ala Asp Phe 
    1250                 1255                 1260             


Trp Arg  Leu Val Phe Asp Tyr  Asn Cys Ser Ser Val  Val Met Leu 
    1265                 1270                 1275             


Asn Glu  Met Asp Thr Ala Gln  Phe Cys Met Gln Tyr  Trp Pro Glu 
    1280                 1285                 1290             


Lys Thr  Ser Gly Cys Tyr Gly  Pro Ile Gln Val Glu  Phe Val Ser 
    1295                 1300                 1305             


Ala Asp  Ile Asp Glu Asp Ile  Ile His Arg Ile Phe  Arg Ile Cys 
    1310                 1315                 1320             


Asn Met  Ala Arg Pro Gln Asp  Gly Tyr Arg Ile Val  Gln His Leu 
    1325                 1330                 1335             


Gln Tyr  Ile Gly Trp Pro Ala  Tyr Arg Asp Thr Pro  Pro Ser Lys 
    1340                 1345                 1350             


Arg Ser  Leu Leu Lys Val Val  Arg Arg Leu Glu Lys  Trp Gln Glu 
    1355                 1360                 1365             


Gln Tyr  Asp Gly Arg Glu Gly  Arg Thr Val Val His  Cys Leu Asn 
    1370                 1375                 1380             


Gly Gly  Gly Arg Ser Gly Thr  Phe Cys Ala Ile Cys  Ser Val Cys 
    1385                 1390                 1395             


Glu Met  Ile Gln Gln Gln Asn  Ile Ile Asp Val Phe  His Ile Val 
    1400                 1405                 1410             


Lys Thr  Leu Arg Asn Asn Lys  Ser Asn Met Val Glu  Thr Leu Glu 
    1415                 1420                 1425             


Gln Tyr  Lys Phe Val Tyr Glu  Val Ala Leu Glu Tyr  Leu Ser Ser 
    1430                 1435                 1440             


Phe 
    


<210>  3922
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3922
cctcccgcct cagttcgcgc cgcgcctcgg cttggaacgc aggagcgccg gctccgggag     60

cccgagcgga gccagccgcg cgcacagcca gcggccgcgc cggcgatgcg gggccacccc    120

gcgcccgccc cagtcccggc cccggccccc gcgggaaggg gctgagctgc ccgccgccgc    180

ccggatggcg agcctcgccg cgctcgccct cagcctgctc ctgaggctgc agctgccgcc    240

actgcccggc gcccgggctc agagcgcccc aggtggctgt tcctttgatg agcactacag    300

caactgtggt tatagtgtgg ctctagggac caatgggttc acctgggagc agattaacac    360

atgggagaaa ccaatgctgg accaggcagt gcccacagga tctttcatga tggtgaacag    420

ctctgggaga gcctctggcc agaaggccca ccttctcctg ccaaccctga aggagaatga    480

cacccactgc atcgacttcc attactactt ctccagccgt gacaggtcca gcccaggggc    540

cttgaacgtc tacgtgaagg tgaatggtgg cccccaaggg aaccctgtgt ggaatgtgtc    600

cggggtcgtc actgagggct gggtgaaggc agagctcgcc atcagcactt tctggccaca    660

tttctatcag gtgatatttg aatccgtctc attgaagggt catcctggct acatcgccgt    720

ggacgaggtc cgggtccttg ctcatccatg cagaaaagca cctcattttc tgcgactcca    780

aaacgtggag gtgaatgtgg ggcagaatgc cacatttcag tgcattgctg gtgggaagtg    840

gtctcagcat gacaagcttt ggctccagca atggaatggc agggacacgg ccctgatggt    900

cacccgtgtg gtcaaccaca ggcgcttctc agccacagtc agtgtggcag acactgccca    960

gcggagcgtc agcaagtacc gctgtgtgat ccgctctgat ggtgggtctg gtgtgtccaa   1020

ctacgcggag ctgatcgtga aagagcctcc cacgcccatt gctcccccag agctgctggc   1080

tgtgggggcc acatacctgt ggatcaagcc aaatgccaac tccatcatcg gggatggccc   1140

catcatcctg aaggaagtgg aatatcgcac caccacaggc acgtgggcag agacccacat   1200

agtcgactct cccaactata agctgtggca tctggacccc gatgttgagt atgagatccg   1260

agtgctcctc acacgaccag gtgagggggg tacgggaccg ccagggcctc ccctcaccac   1320

caggaccaag tgtgcagatc cggtacatgg cccacagaac gtggaaatcg tagacatcag   1380

agcccggcag ctgaccctgc agtgggagcc cttcggctac gcggtgaccc gctgccatag   1440

ctacaacctc accgtgcagt accagtatgt gttcaaccag cagcagtacg aggccgagga   1500

ggtcatccag acctcctccc actacaccct gcgaggcctg cgccccttca tgaccatccg   1560

gctgcgactc ttgctgtcta accccgaggg ccgaatggag agcgaggagc tggtggtgca   1620

gactgaggaa gacgttccag gagctgttcc tctagaatcc atccaagggg ggccctttga   1680

ggagaagatc tacatccagt ggaaacctcc caatgagacc aatggggtca tcacgctcta   1740

cgagatcaac tacaaggctg tcggctcgct ggacccaagt gctgacctct cgagccagag   1800

ggggaaagtg ttcaagctcc ggaatgaaac ccaccacctc tttgtgggtc tgtacccagg   1860

gaccacctat tccttcacca tcaaggccag cacagcaaag ggctttgggc cccctgtcac   1920

cactcggatt gccaccaaaa tttcagctcc atccatgcct gagtacgaca cagacacccc   1980

attgaatgag acagacacga ccatcacagt gatgctgaaa cccgctcagt cccggggagc   2040

tcctgtcagt gtttatcagc tggttgtcaa ggaggagcga cttcagaagt cacggagggc   2100

agctgacatt attgagtgct tttcggtgcc cgtgagctat cggaatgcct ccagcctcga   2160

ttctctacac tactttgctg ctgagttgaa gcctgccaac ctgcctgtca cccagccatt   2220

tacagtgggt gacaataaga catacaatgg ctactggaac cctcctctct ctcccctgaa   2280

aagctacagc atctacttcc aggcactcag caaagccaat ggagagacca aaatcaactg   2340

tgttcgtctg gctacaaaag caccaatggg cagcgcccag gtgaccccgg ggactccact   2400

ctgcctcctc accacaggtg cctccaccca gaattctaac actgtggagc cagagaagca   2460

ggtggacaac accgtgaaga tggctggcgt gatcgctggc ctcctcatgt tcatcatcat   2520

tctcctgggc gtgatgctca ccatcaaaag gagaagaaat gcttattcct actcctatta   2580

cttgtcccaa aggaagctgg ccaagaagca gaaggagacc cagagtggag cccagaggga   2640

gatggggcct gtggcctctg ccgacaaacc caccaccaag ctcagcgcca gccgcaatga   2700

tgaaggcttc tcttctagtt ctcaggacgt caacggattc acagatggca gccgcgggga   2760

gctttcccag cccaccctca cgatccagac tcatccctac cgcacctgtg accctgtgga   2820

gatgagctac ccccgggacc agttccaacc cgccatccgg gtggctgact tgctgcagca   2880

catcacgcag atgaagagag gccagggcta cgggttcaag gaggaatacg aggccttacc   2940

agaggggcag acagcttcgt gggacacagc caaggaggat gaaaaccgca ataagaatcg   3000

atatgggaac atcatatcct acgaccattc ccgggtgagg ctgctggtgc tggatggaga   3060

cccgcactct gactacatca atgccaacta cattgacgga taccatcgac ctcggcacta   3120

cattgcgact caaggtccga tgcaggagac tgtaaaggac ttttggagaa tgatctggca   3180

ggagaactcc gccagcatcg tcatggtcac aaacctggtg gaagtgggca gggtgaaatg   3240

tgtgcgatac tggccagatg acacggaggt ctacggagac attaaagtca ccctgattga   3300

aacagagccc ctggcagaat acgtcatacg caccttcaca gtccagaaga aaggctacca   3360

tgagatccgg gagctccgcc tcttccactt caccagctgg cctgaccacg gcgttccctg   3420

ctatgccact ggccttctgg gcttcgtccg ccaggtcaag ttcctcaacc ccccggaagc   3480

tgggcccata gtggtccact gcagtgctgg ggctgggcgg actggctgct tcattgccat   3540

tgacaccatg cttgacatgg ccgagaatga aggggtggtg gacatcttca actgcgtgcg   3600

tgagctccgg gcccaaaggg tcaacctggt acagacagag gagcaatatg tgtttgtgca   3660

cgatgccatc ctggaagcgt gcctctgtgg caacactgcc atccctgtgt gtgagttccg   3720

ttctctctac tacaatatca gcaggctgga cccccagaca aactccagcc aaatcaaaga   3780

tgaatttcag accctcaaca ttgtgacacc ccgtgtgcgg cccgaggact gcagcattgg   3840

gctcctgccc cggaaccatg ataagaatcg aagtatggac gtgctgcctc tggaccgctg   3900

cctgcccttc cttatctcag tggacggaga atccagcaat tacatcaacg cagcactgat   3960

ggatagccac aagcagcctg ccgccttcgt ggtcacccag caccctctac ccaacaccgt   4020

ggcagacttc tggaggctgg tgttcgatta caactgctcc tctgtggtga tgctgaatga   4080

gatggacact gcccagttct gtatgcagta ctggcctgag aagacctccg ggtgctatgg   4140

gcccatccag gtggagttcg tctccgcaga catcgacgag gacatcatcc acagaatatt   4200

ccgcatctgt aacatggccc ggccacagga tggttatcgt atagtccagc acctccagta   4260

cattggctgg cctgcctacc gggacacgcc cccctccaag cgctctctgc tcaaagtggt   4320

ccgacgactg gagaagtggc aggagcagta tgacgggagg gagggacgta ctgtggtcca   4380

ctgcctaaat gggggaggcc gtagtggaac cttctgtgcc atctgcagtg tgtgtgagat   4440

gatccagcag caaaacatca ttgacgtgtt ccacatcgtg aaaacactgc gtaacaacaa   4500

atccaacatg gtggagaccc tggaacagta taaatttgta tacgaggtgg cactggaata   4560

tttaagctcc ttttagctca atgggatggg gaacctgccg gagtccagag gctgctgtga   4620

ccaagccccc ttttgtgtga atggcagtaa ctgggctcag gagctctgag gtggcaccct   4680

gcctgactcc aaggagaaga ctggtggccc tgtgttccac ggggggctct gcaccttctg   4740

aggggtctcc tgttgccgtg ggagatgctg ctccaaaagg cccaggcttc cttttcaacc   4800

taaccagcca cagccaaggg cccaagcaga agtacaccca caagcaaggc cttggatttc   4860

tggctcccag accacctgct tttgttctga gtttgtggat ctcttggcaa gccaactgtg   4920

caggtgctgg ggagtgggag gctcccctgc cctccttctc cttaggagtg gaggagatgt   4980

gtgttctgct cctctacgtc atggaaaaga ttgaggctct tgggggtcac tgctctgctg   5040

ccccctgcaa cctccttcag gggcctctgg caccagacat ttgcagtctg gaccagtgtg   5100

accttacgat gttccctagg ccacaagaga ggccccccat cctcacacct aacctgcatg   5160

gggcttcgcc cacaaccatt ctgtacccct tccccagcct gggccttgac cgtccagcat   5220

tcactggccg gccagctgtg tccacagcag tttttgataa aggtgttctt tgcttttttg   5280

tgtggtcagt gggagggggt ggaactgcag ggaacttctc tgctcctcct tgtctttgta   5340

aaaagggacc acctccctgg ggcagggctt gggctgacct gtaggatgta acccctgtgt   5400

ttctttggtg gtagctttct ttggaagaga caaacaagat aagatttgat tattttccaa   5460

agtgtatgtg aaaagaaact ttcttttgga gggtgtaaaa tcttagtctc ttatgtcaaa   5520

aagaaggggg cgggggagtt tgagtatgta cctctaagac aaatctctcg ggccttttat   5580

tttttcctgg caatgtcctt aaaagctccc accctgggac agcatgccac tgagcaagga   5640

gagatgggtg agcctgaaga tggtcccttt ggtttctggg gcaaatagag caccagcttt   5700

gtgcataatt tggatgtcca aatttgaact ccttcctaaa gaaacccagc agccaccttg   5760

aaaaaggcca ttgtggagcc cattatactt tgatttaaaa taggccaaga gaatcaggcc   5820

tggagatcta gggtcttgtc caaagtgtga gtgagtcaat gagagggaac caacatttgc   5880

taagtctcta ctgtatgcca gggatcatgc ttggcacttt ccataggaca tttcacacag   5940

tccttagaac ccccaggaga gagctactga cttgttatca tctccatttg atcatctcct   6000

ccaatgagga aacccacgca ccttccttag taatgaaatc ctgggttcca aaggggcagg   6060

taatggcaat gagacttctc cgtgctgttt tcttcatctt ctctaagcca agcaattatt   6120

ttatggaggg aaaataaggc cagaaacttc tgagcagata actccacaaa tggaaattta   6180

gtactttctt cctgatgcca gttcttctgg gaagcgcaga atttcagata tattttagta   6240

acacattccc agctccccag gaaagccagt ctcatctaat ttcttagtca gtaaaaacaa   6300

ttccctgttc cttcaggcta tgaatggacc agccagggaa actctcgacc ttgatctcta   6360

gccagtgctt aggcccaata tctgacagcc tcaggtgggc tgggacctag gaagctccat   6420

cttgaaggct ggtctagccc cagacagggc atgaggggca gagaattcaa gaaggtacag   6480

ctttggccct caagagccca ctgtatgctg gggaaatgga accatggtgc agtagtgtgg   6540

agtggatgag tgttccatga gcctaggagc aagaaagtct cttcggcctc gggcttcctg   6600

gagaagggga cgtccattcc tgctgggtct taacaagcat aaaaaggaaa aaaaggaaac   6660

tcaggcaaag ggatccatat gtgcaatggc aaagaaatgt gaaaaggcat tgggagaagc   6720

agtctggggg aggccagccc agtgcgggca cagcacaaca cggggagcag caagagatga   6780

gccagggtcc aggagacaga tgcccatcgc gagtacagac tttgtcctat tggcaacaag   6840

gagtccatgg agctttagag agatgcactc agcttcgtgt tggccaagac tccttctggg   6900

ccaatggggc tgcctctttt cctttcatca gacactgtga aaacattccc ttaagcgtgc   6960

actttttaat atcacatcta tttgtctgtc tgctcattgt tttgttgctg gaactaaata   7020

tgcaatggat catgagactc agattctatg agaaacccag ggtctctgct ttaccacgga   7080

gcagggtcac caacccagat ctccaggccc atgaggatgg aacatgaaag gagccgacaa   7140

aagttgcttc cattggcatg ggctctggag ctgtccagaa gtccagggac accagacttg   7200

atcaaggaag ggctgtcact ttagaggttc aaaaggaagt gcctcaaagc aaaggcaagc   7260

aaaggaaccc cacgatgaac ttgctctttt cctttgatga gcctctcccc aggtgtattt   7320

cagcagaccc cggggaccca cccccactgg gcctgctggc ctccctcggc tccagcccaa   7380

tgccccagct ggccttcccc agcctgcaag gagcctgtag catggcaaat ctgcctgctg   7440

tatgctattt tcttagatct tggtacatcc agacaggatg agggtggagg gagagctatt   7500

taacacaaat cctaagattt ttttctgctc aggaaggggt gaaatagctg gcagatacaa   7560

aagacagtgg cttttatcat tttaaatggt aggaatttaa ggtgtgactt cagggagaaa   7620

caaacttgca aaaaaaaaaa atctcaggcc atgttggggt aacccagcaa gggccagtga   7680

tgatttcccc cagctcatcc ccttattttc ccacaaccca accattctct aaagcaggac   7740

agtgaatagg tcttaggcca gtgcacacag gaagaaattg aggcttatgg atggggatga   7800

cttccctaag atcccatggg acaaggatgt ggcaaggctt ggatgagatg gggcaccagt   7860

gcccaggaat ttgaacattt tcctttaccc aggaaatctc cggagccaac accaccaccc   7920

ccagggggtc tccccacccc accccattta cagggtgagc tcagcctgtc atgagcagag   7980

gaaaatatta ttaatgctct ctgagtcttt acaacaggag ctcttacctc atagatgtgg   8040

gctctgtttg gggaagatgc aaggaagtaa tgagaagccc aggaaatttc tccacctgtg   8100

tttatggcct aaatagcttc aggatgtatc ttagctgcac tccaacattg catcctttct   8160

ggggtgaaga atctgggcca accaggggtc ct                                 8192


<210>  3923
<211>  1463
<212>  PRT
<213>  Homosapiens

<400>  3923

Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln 
1               5                   10                  15      


Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Pro Gly Gly Cys 
            20                  25                  30          


Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly 
        35                  40                  45              


Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Trp Glu Lys Pro Met 
    50                  55                  60                  


Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser 
65                  70                  75                  80  


Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys 
                85                  90                  95      


Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg 
            100                 105                 110         


Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly 
        115                 120                 125             


Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu 
    130                 135                 140                 


Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe 
145                 150                 155                 160 


Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr 
                165                 170                 175     


Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala 
            180                 185                 190         


Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn 
        195                 200                 205             


Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys 
    210                 215                 220                 


Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr 
225                 230                 235                 240 


Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp 
                245                 250                 255     


Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp 
            260                 265                 270         


Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro 
        275                 280                 285             


Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr 
    290                 295                 300                 


Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile 
305                 310                 315                 320 


Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu 
                325                 330                 335     


Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro 
            340                 345                 350         


Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly 
        355                 360                 365             


Gly Thr Gly Pro Pro Gly Pro Pro Leu Thr Thr Arg Thr Lys Cys Ala 
    370                 375                 380                 


Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala 
385                 390                 395                 400 


Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg 
                405                 410                 415     


Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln 
            420                 425                 430         


Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr 
        435                 440                 445             


Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu 
    450                 455                 460                 


Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr 
465                 470                 475                 480 


Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly 
                485                 490                 495     


Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr 
            500                 505                 510         


Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser 
        515                 520                 525             


Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys 
    530                 535                 540                 


Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr 
545                 550                 555                 560 


Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro 
                565                 570                 575     


Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro 
            580                 585                 590         


Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr 
        595                 600                 605             


Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr 
    610                 615                 620                 


Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala 
625                 630                 635                 640 


Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser 
                645                 650                 655     


Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn 
            660                 665                 670         


Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn 
        675                 680                 685             


Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr 
    690                 695                 700                 


Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val 
705                 710                 715                 720 


Arg Leu Ala Thr Lys Ala Pro Met Gly Ser Ala Gln Val Thr Pro Gly 
                725                 730                 735     


Thr Pro Leu Cys Leu Leu Thr Thr Gly Ala Ser Thr Gln Asn Ser Asn 
            740                 745                 750         


Thr Val Glu Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly 
        755                 760                 765             


Val Ile Ala Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met 
    770                 775                 780                 


Leu Thr Ile Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu 
785                 790                 795                 800 


Ser Gln Arg Lys Leu Ala Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala 
                805                 810                 815     


Gln Arg Glu Met Gly Pro Val Ala Ser Ala Asp Lys Pro Thr Thr Lys 
            820                 825                 830         


Leu Ser Ala Ser Arg Asn Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp 
        835                 840                 845             


Val Asn Gly Phe Thr Asp Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr 
    850                 855                 860                 


Leu Thr Ile Gln Thr His Pro Tyr Arg Thr Cys Asp Pro Val Glu Met 
865                 870                 875                 880 


Ser Tyr Pro Arg Asp Gln Phe Gln Pro Ala Ile Arg Val Ala Asp Leu 
                885                 890                 895     


Leu Gln His Ile Thr Gln Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys 
            900                 905                 910         


Glu Glu Tyr Glu Ala Leu Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr 
        915                 920                 925             


Ala Lys Glu Asp Glu Asn Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile 
    930                 935                 940                 


Ser Tyr Asp His Ser Arg Val Arg Leu Leu Val Leu Asp Gly Asp Pro 
945                 950                 955                 960 


His Ser Asp Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro 
                965                 970                 975     


Arg His Tyr Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Val Lys Asp 
            980                 985                 990         


Phe Trp Arg Met Ile Trp Gln Glu  Asn Ser Ala Ser Ile  Val Met Val 
        995                 1000                 1005             


Thr Asn  Leu Val Glu Val Gly  Arg Val Lys Cys Val  Arg Tyr Trp 
    1010                 1015                 1020             


Pro Asp  Asp Thr Glu Val Tyr  Gly Asp Ile Lys Val  Thr Leu Ile 
    1025                 1030                 1035             


Glu Thr  Glu Pro Leu Ala Glu  Tyr Val Ile Arg Thr  Phe Thr Val 
    1040                 1045                 1050             


Gln Lys  Lys Gly Tyr His Glu  Ile Arg Glu Leu Arg  Leu Phe His 
    1055                 1060                 1065             


Phe Thr  Ser Trp Pro Asp His  Gly Val Pro Cys Tyr  Ala Thr Gly 
    1070                 1075                 1080             


Leu Leu  Gly Phe Val Arg Gln  Val Lys Phe Leu Asn  Pro Pro Glu 
    1085                 1090                 1095             


Ala Gly  Pro Ile Val Val His  Cys Ser Ala Gly Ala  Gly Arg Thr 
    1100                 1105                 1110             


Gly Cys  Phe Ile Ala Ile Asp  Thr Met Leu Asp Met  Ala Glu Asn 
    1115                 1120                 1125             


Glu Gly  Val Val Asp Ile Phe  Asn Cys Val Arg Glu  Leu Arg Ala 
    1130                 1135                 1140             


Gln Arg  Val Asn Leu Val Gln  Thr Glu Glu Gln Tyr  Val Phe Val 
    1145                 1150                 1155             


His Asp  Ala Ile Leu Glu Ala  Cys Leu Cys Gly Asn  Thr Ala Ile 
    1160                 1165                 1170             


Pro Val  Cys Glu Phe Arg Ser  Leu Tyr Tyr Asn Ile  Ser Arg Leu 
    1175                 1180                 1185             


Asp Pro  Gln Thr Asn Ser Ser  Gln Ile Lys Asp Glu  Phe Gln Thr 
    1190                 1195                 1200             


Leu Asn  Ile Val Thr Pro Arg  Val Arg Pro Glu Asp  Cys Ser Ile 
    1205                 1210                 1215             


Gly Leu  Leu Pro Arg Asn His  Asp Lys Asn Arg Ser  Met Asp Val 
    1220                 1225                 1230             


Leu Pro  Leu Asp Arg Cys Leu  Pro Phe Leu Ile Ser  Val Asp Gly 
    1235                 1240                 1245             


Glu Ser  Ser Asn Tyr Ile Asn  Ala Ala Leu Met Asp  Ser His Lys 
    1250                 1255                 1260             


Gln Pro  Ala Ala Phe Val Val  Thr Gln His Pro Leu  Pro Asn Thr 
    1265                 1270                 1275             


Val Ala  Asp Phe Trp Arg Leu  Val Phe Asp Tyr Asn  Cys Ser Ser 
    1280                 1285                 1290             


Val Val  Met Leu Asn Glu Met  Asp Thr Ala Gln Phe  Cys Met Gln 
    1295                 1300                 1305             


Tyr Trp  Pro Glu Lys Thr Ser  Gly Cys Tyr Gly Pro  Ile Gln Val 
    1310                 1315                 1320             


Glu Phe  Val Ser Ala Asp Ile  Asp Glu Asp Ile Ile  His Arg Ile 
    1325                 1330                 1335             


Phe Arg  Ile Cys Asn Met Ala  Arg Pro Gln Asp Gly  Tyr Arg Ile 
    1340                 1345                 1350             


Val Gln  His Leu Gln Tyr Ile  Gly Trp Pro Ala Tyr  Arg Asp Thr 
    1355                 1360                 1365             


Pro Pro  Ser Lys Arg Ser Leu  Leu Lys Val Val Arg  Arg Leu Glu 
    1370                 1375                 1380             


Lys Trp  Gln Glu Gln Tyr Asp  Gly Arg Glu Gly Arg  Thr Val Val 
    1385                 1390                 1395             


His Cys  Leu Asn Gly Gly Gly  Arg Ser Gly Thr Phe  Cys Ala Ile 
    1400                 1405                 1410             


Cys Ser  Val Cys Glu Met Ile  Gln Gln Gln Asn Ile  Ile Asp Val 
    1415                 1420                 1425             


Phe His  Ile Val Lys Thr Leu  Arg Asn Asn Lys Ser  Asn Met Val 
    1430                 1435                 1440             


Glu Thr  Leu Glu Gln Tyr Lys  Phe Val Tyr Glu Val  Ala Leu Glu 
    1445                 1450                 1455             


Tyr Leu  Ser Ser Phe 
    1460             


<210>  3924
<211>  2731
<212>  DNA
<213>  Homosapiens

<400>  3924
gcgcttggcg ggagatagaa aagtgcttca acccgcgccg gcggcgactg cagttcctgc     60

gagcgaggag cgcgggacct gctgacacgc tgacgccttc gagcgcggcc cggggcccgg    120

agcggccgga gcagcccggg tcctgacccc ggcccggctc ccgctccggg ctctgccggc    180

gggcgggcga gcgcggcgcg gtccgggccg gggggatgtc tcggcggacg cgctgcgagg    240

atctggatga gctgcactac caggacacag attcagatgt gccggagcag agggatagca    300

agtgcaaggt caaatggacc catgaggagg acgagcagct gagggccctg gtgaggcagt    360

ttggacagca ggactggaag ttcctggcca gccacttccc taaccgcact gaccagcaat    420

gccagtacag gtggctgaga gttttgaatc cagaccttgt caaggggcca tggaccaaag    480

aggaagacca aaaagtcatc gagctggtta agaagtatgg cacaaagcag tggacactga    540

ttgccaagca cctgaagggc cggctgggga agcagtgccg tgaacgctgg cacaaccacc    600

tcaaccctga ggtgaagaag tcttgctgga ccgaggagga ggaccgcatc atctgcgagg    660

cccacaaggt gctgggcaac cgctgggccg agatcgccaa gatgttgcca gggaggacag    720

acaatgctgt gaagaatcac tggaactcta ccatcaaaag gaaggtggac acaggaggct    780

tcttgagcga gtccaaagac tgcaagcccc cagtgtactt gctgctggag ctcgaggaca    840

aggacggcct ccagagtgcc cagcccacgg aaggccaggg aagtcttctg accaactggc    900

cctccgtccc tcctaccata aaggaggagg aaaacagtga ggaggaactt gcagcagcca    960

ccacatcgaa ggaacaggag cccatcggta cagatctgga cgcagtgcga acaccagagc   1020

ccttggagga attcccgaag cgtgaggacc aggaaggctc cccaccagaa acgagcctgc   1080

cttacaagtg ggtggtggag gcagctaacc tcctcatccc cgctgtgggt tctagcctct   1140

ctgaagccct ggacttgatc gagtcggacc ctgatgcttg gtgtgacctg agtaaatttg   1200

acctccctga ggaaccatct gcagaggaca gtatcaacaa cagcctagtg cagctgcaag   1260

cgtcacatca gcagcaagtc ctgccacccc gccagccttc cgccctggtg cccagtgtga   1320

ccgagtaccg cctggatggc cacaccatct cagacctgag ccggagcagc cggggcgagc   1380

tgatccccat ctcccccagc actgaagtcg ggggctctgg cattggcaca ccgccctctg   1440

tgctcaagcg gcagaggaag aggcgtgtgg ctctgtcccc tgtcactgag aatagcacca   1500

gtctgtcctt cctggattcc tgtaacagcc tcacgcccaa gagcacacct gttaagaccc   1560

tgcccttctc gccctcccag tttctgaact tctggaacaa acaggacaca ttggagctgg   1620

agagcccctc gctgacatcc accccagtgt gcagccagaa ggtggtggtc accacaccac   1680

tgcaccggga caagacaccc ctgcaccaga aacatgctgc gtttgtaacc ccagatcaga   1740

agtactccat ggacaacact ccccacacgc caaccccgtt caagaacgcc ctggagaagt   1800

acggacccct gaagcccctg ccacagaccc cgcacctgga ggaggacttg aaggaggtgc   1860

tgcgttctga ggctggcatc gaactcatca tcgaggacga catcaggccc gagaagcaga   1920

agaggaagcc tgggctgcgg cggagcccca tcaagaaagt ccggaagtct ctggctcttg   1980

acattgtgga tgaggatgtg aagctgatga tgtccacact gcccaagtct ctatccttgc   2040

cgacaactgc cccttcaaac tcttccagcc tcaccctgtc aggtatcaaa gaagacaaca   2100

gcttgctcaa ccagggcttc ttgcaggcca agcccgagaa ggcagcagtg gcccagaagc   2160

cccgaagcca cttcacgaca cctgccccta tgtccagtgc ctggaagacg gtggcctgcg   2220

gggggaccag ggaccagctt ttcatgcagg agaaagcccg gcagctcctg ggccgcctga   2280

agcccagcca cacatctcgg accctcatct tgtcctgagg tgttgagggt gtcacgagcc   2340

cattctcatg tttacagggg ttgtgggggc agagggggtc tgtgaatctg agagtcattc   2400

aggtgacctc ctgcagggag ccttctgcca ccagcccctc cccagactct caggtggagg   2460

caacagggcc atgtgctgcc ctgttgccga gcccagctgt gggcggctcc tggtgctaac   2520

aacaaagttc cacttccagg tctgcctggt tccctcccca aggccacagg gagctccgtc   2580

agcttctccc aagcccacgt caggcctggc ctcatctcag accctgctta ggatggggga   2640

tgtggccagg ggtgctcctg tgctcaccct ctcttggtgc atttttttgg aagaataaaa   2700

ttgcctctct cttaaaaaaa aaaaaaaaaa a                                  2731


<210>  3925
<211>  700
<212>  PRT
<213>  Homosapiens

<400>  3925

Met Ser Arg Arg Thr Arg Cys Glu Asp Leu Asp Glu Leu His Tyr Gln 
1               5                   10                  15      


Asp Thr Asp Ser Asp Val Pro Glu Gln Arg Asp Ser Lys Cys Lys Val 
            20                  25                  30          


Lys Trp Thr His Glu Glu Asp Glu Gln Leu Arg Ala Leu Val Arg Gln 
        35                  40                  45              


Phe Gly Gln Gln Asp Trp Lys Phe Leu Ala Ser His Phe Pro Asn Arg 
    50                  55                  60                  


Thr Asp Gln Gln Cys Gln Tyr Arg Trp Leu Arg Val Leu Asn Pro Asp 
65                  70                  75                  80  


Leu Val Lys Gly Pro Trp Thr Lys Glu Glu Asp Gln Lys Val Ile Glu 
                85                  90                  95      


Leu Val Lys Lys Tyr Gly Thr Lys Gln Trp Thr Leu Ile Ala Lys His 
            100                 105                 110         


Leu Lys Gly Arg Leu Gly Lys Gln Cys Arg Glu Arg Trp His Asn His 
        115                 120                 125             


Leu Asn Pro Glu Val Lys Lys Ser Cys Trp Thr Glu Glu Glu Asp Arg 
    130                 135                 140                 


Ile Ile Cys Glu Ala His Lys Val Leu Gly Asn Arg Trp Ala Glu Ile 
145                 150                 155                 160 


Ala Lys Met Leu Pro Gly Arg Thr Asp Asn Ala Val Lys Asn His Trp 
                165                 170                 175     


Asn Ser Thr Ile Lys Arg Lys Val Asp Thr Gly Gly Phe Leu Ser Glu 
            180                 185                 190         


Ser Lys Asp Cys Lys Pro Pro Val Tyr Leu Leu Leu Glu Leu Glu Asp 
        195                 200                 205             


Lys Asp Gly Leu Gln Ser Ala Gln Pro Thr Glu Gly Gln Gly Ser Leu 
    210                 215                 220                 


Leu Thr Asn Trp Pro Ser Val Pro Pro Thr Ile Lys Glu Glu Glu Asn 
225                 230                 235                 240 


Ser Glu Glu Glu Leu Ala Ala Ala Thr Thr Ser Lys Glu Gln Glu Pro 
                245                 250                 255     


Ile Gly Thr Asp Leu Asp Ala Val Arg Thr Pro Glu Pro Leu Glu Glu 
            260                 265                 270         


Phe Pro Lys Arg Glu Asp Gln Glu Gly Ser Pro Pro Glu Thr Ser Leu 
        275                 280                 285             


Pro Tyr Lys Trp Val Val Glu Ala Ala Asn Leu Leu Ile Pro Ala Val 
    290                 295                 300                 


Gly Ser Ser Leu Ser Glu Ala Leu Asp Leu Ile Glu Ser Asp Pro Asp 
305                 310                 315                 320 


Ala Trp Cys Asp Leu Ser Lys Phe Asp Leu Pro Glu Glu Pro Ser Ala 
                325                 330                 335     


Glu Asp Ser Ile Asn Asn Ser Leu Val Gln Leu Gln Ala Ser His Gln 
            340                 345                 350         


Gln Gln Val Leu Pro Pro Arg Gln Pro Ser Ala Leu Val Pro Ser Val 
        355                 360                 365             


Thr Glu Tyr Arg Leu Asp Gly His Thr Ile Ser Asp Leu Ser Arg Ser 
    370                 375                 380                 


Ser Arg Gly Glu Leu Ile Pro Ile Ser Pro Ser Thr Glu Val Gly Gly 
385                 390                 395                 400 


Ser Gly Ile Gly Thr Pro Pro Ser Val Leu Lys Arg Gln Arg Lys Arg 
                405                 410                 415     


Arg Val Ala Leu Ser Pro Val Thr Glu Asn Ser Thr Ser Leu Ser Phe 
            420                 425                 430         


Leu Asp Ser Cys Asn Ser Leu Thr Pro Lys Ser Thr Pro Val Lys Thr 
        435                 440                 445             


Leu Pro Phe Ser Pro Ser Gln Phe Leu Asn Phe Trp Asn Lys Gln Asp 
    450                 455                 460                 


Thr Leu Glu Leu Glu Ser Pro Ser Leu Thr Ser Thr Pro Val Cys Ser 
465                 470                 475                 480 


Gln Lys Val Val Val Thr Thr Pro Leu His Arg Asp Lys Thr Pro Leu 
                485                 490                 495     


His Gln Lys His Ala Ala Phe Val Thr Pro Asp Gln Lys Tyr Ser Met 
            500                 505                 510         


Asp Asn Thr Pro His Thr Pro Thr Pro Phe Lys Asn Ala Leu Glu Lys 
        515                 520                 525             


Tyr Gly Pro Leu Lys Pro Leu Pro Gln Thr Pro His Leu Glu Glu Asp 
    530                 535                 540                 


Leu Lys Glu Val Leu Arg Ser Glu Ala Gly Ile Glu Leu Ile Ile Glu 
545                 550                 555                 560 


Asp Asp Ile Arg Pro Glu Lys Gln Lys Arg Lys Pro Gly Leu Arg Arg 
                565                 570                 575     


Ser Pro Ile Lys Lys Val Arg Lys Ser Leu Ala Leu Asp Ile Val Asp 
            580                 585                 590         


Glu Asp Val Lys Leu Met Met Ser Thr Leu Pro Lys Ser Leu Ser Leu 
        595                 600                 605             


Pro Thr Thr Ala Pro Ser Asn Ser Ser Ser Leu Thr Leu Ser Gly Ile 
    610                 615                 620                 


Lys Glu Asp Asn Ser Leu Leu Asn Gln Gly Phe Leu Gln Ala Lys Pro 
625                 630                 635                 640 


Glu Lys Ala Ala Val Ala Gln Lys Pro Arg Ser His Phe Thr Thr Pro 
                645                 650                 655     


Ala Pro Met Ser Ser Ala Trp Lys Thr Val Ala Cys Gly Gly Thr Arg 
            660                 665                 670         


Asp Gln Leu Phe Met Gln Glu Lys Ala Arg Gln Leu Leu Gly Arg Leu 
        675                 680                 685             


Lys Pro Ser His Thr Ser Arg Thr Leu Ile Leu Ser 
    690                 695                 700 


<210>  3926
<211>  773
<212>  DNA
<213>  Homosapiens

<400>  3926
gacatcatag tatatccgtg agtcaagcgg ctgtgggttt ttggctcttg catctgctat     60

agttctgtct cgggtgccat ttgctaactc tgttctctgt gtagctgctt ttggcagctc    120

ctcatctctc ttctaatcca ccactcacag tcctagagaa cagaccacaa gttaagaccg    180

tcacctacag aatcccaagg gccaaaactg ggcagaggac aactccatcc ttcttacaaa    240

agggcttctc cacaagaagc atttccgtta gactctagca gtgagatacc ctgcttcaag    300

aatttctcat ggagccagaa gcctttgaaa tttgccctta tgatcctcac caccgaatcc    360

cactcagcag attccagtac cacctggcat cgtgcaggag aaagaacccc aagaaagcca    420

aaaagatggc cacctgcaaa tacaacgcct gccacgtggt ccccatcaaa aatctggagg    480

aacatgaggc tgtttgtgtc aacaggagcg ctgtggaaga agaggacacc gagaaccctc    540

tgaaagtcag tcctcctagt tcagagcaga acgatgacac ccagcagact ttttttcctc    600

aaaaggttgt ttgtgaaaat gacacgaaag agtcagcaag agagaccagt ccccagaaga    660

tcctcagacc aggacagtaa actgccagct gaggaaggag cacacgcctc atcaatgcat    720

ggaagaacgt gcaatgcatc agaataaaag acatgcaaag taaactaaaa aaa           773


<210>  3927
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  3927

Met Glu Pro Glu Ala Phe Glu Ile Cys Pro Tyr Asp Pro His His Arg 
1               5                   10                  15      


Ile Pro Leu Ser Arg Phe Gln Tyr His Leu Ala Ser Cys Arg Arg Lys 
            20                  25                  30          


Asn Pro Lys Lys Ala Lys Lys Met Ala Thr Cys Lys Tyr Asn Ala Cys 
        35                  40                  45              


His Val Val Pro Ile Lys Asn Leu Glu Glu His Glu Ala Val Cys Val 
    50                  55                  60                  


Asn Arg Ser Ala Val Glu Glu Glu Asp Thr Glu Asn Pro Leu Lys Val 
65                  70                  75                  80  


Ser Pro Pro Ser Ser Glu Gln Asn Asp Asp Thr Gln Gln Thr Phe Phe 
                85                  90                  95      


Pro Gln Lys Val Val Cys Glu Asn Asp Thr Lys Glu Ser Ala Arg Glu 
            100                 105                 110         


Thr Ser Pro Gln Lys Ile Leu Arg Pro Gly Gln 
        115                 120             


<210>  3928
<211>  842
<212>  DNA
<213>  Homosapiens

<400>  3928
gacatcatag tatatccgtg agtcaagcgg ctgtgggttt ttggctcttg catctgctat     60

agttctgtct cgggtgccat ttgctaactc tgttctctgt gtagctgctt ttggcagctc    120

ctcatctctc ttctaatcca ccactcacag tcctagagaa cagaccacaa gttaagaccg    180

tcacctacag aatcccaagg gccaaaactg ggcagaggac aactccatcc ttcttacaaa    240

agggcttctc cacaagaagc atttccgtta gactctagca gtgagatacc ctgcttcaag    300

aatttctcat ggagccagaa gcctttgaaa tttgccctta tgatcctcac caccgaatcc    360

cactcagcag attccagtac cacctggcat cgtgcaggag aaagaacccc aagaaagcca    420

aaaagatggc cacctgcaaa tacaacgcct gccacgtggt ccccatcaaa aatctggagg    480

aacatgaggc tgtttgtgtc aacaggagcg ctgtggaaga agaggacacc gagaaccctc    540

tgaaagtcag tcctcctagt tcagagcaga acgatgacac ccagcaggtc tcaccctgcc    600

ttcccagccc cgatatctgg aatgtcgatg gcgctaattg ccagcatgtg tttgtcctta    660

agactttttt tcctcaaaag gttgtttgtg aaaatgacac gaaagagtca gcaagagaga    720

ccagtcccca gaagatcctc agaccaggac agtaaactgc cagctgagga aggagcacac    780

gcctcatcaa tgcatggaag aacgtgcaat gcatcagaat aaaagacatg caaagtaaac    840

ta                                                                   842


<210>  3929
<211>  148
<212>  PRT
<213>  Homosapiens

<400>  3929

Met Glu Pro Glu Ala Phe Glu Ile Cys Pro Tyr Asp Pro His His Arg 
1               5                   10                  15      


Ile Pro Leu Ser Arg Phe Gln Tyr His Leu Ala Ser Cys Arg Arg Lys 
            20                  25                  30          


Asn Pro Lys Lys Ala Lys Lys Met Ala Thr Cys Lys Tyr Asn Ala Cys 
        35                  40                  45              


His Val Val Pro Ile Lys Asn Leu Glu Glu His Glu Ala Val Cys Val 
    50                  55                  60                  


Asn Arg Ser Ala Val Glu Glu Glu Asp Thr Glu Asn Pro Leu Lys Val 
65                  70                  75                  80  


Ser Pro Pro Ser Ser Glu Gln Asn Asp Asp Thr Gln Gln Val Ser Pro 
                85                  90                  95      


Cys Leu Pro Ser Pro Asp Ile Trp Asn Val Asp Gly Ala Asn Cys Gln 
            100                 105                 110         


His Val Phe Val Leu Lys Thr Phe Phe Pro Gln Lys Val Val Cys Glu 
        115                 120                 125             


Asn Asp Thr Lys Glu Ser Ala Arg Glu Thr Ser Pro Gln Lys Ile Leu 
    130                 135                 140                 


Arg Pro Gly Gln 
145             


<210>  3930
<211>  2533
<212>  DNA
<213>  Homosapiens

<400>  3930
cgcagccctg gcgcagacgc gtgggctccg tggcgatgcg gggtgttgcc tgaggctcca     60

ctgaagctat ggcataattt gcagaatttg cacttcatta cttttctgaa attcaaacaa    120

attctgaaac tgcacgagtt ctggctgaga gctgtggatc tgtgcatttt gatggtgaca    180

gtgcctacgt ggggatgagt gacggaaacc cagagctcct gtcaaccagc cagacctaca    240

acggccagag cgagaacaac gaagactatg agatcccccc gataacacct cccaacctcc    300

cggagccatc cctcctgcac ctgggggacc acgaagccag ctaccactcg ctgtgccacg    360

gcctcacccc caacggtctg ctccctgcct actcctatca ggccatggac ctcccagcca    420

tcatggtgtc caacatgcta gcacaggaca gccacctgct gtcgggccag ctgcccacga    480

tccaggagat ggtccactcg gaagtggctg cctatgactc gggccggccc gggcccctgc    540

tgggtcgccc ggcaatgctg gccagccaca tgagtgccct cagccagtcc cagctcatct    600

cgcagatggg catccggagc agcatcgccc acagctcccc atcaccgccg gggagcaagt    660

cagcgacccc ctctccctcc agctccactc aggaagagga gtcggaagtg catttcaaga    720

tctcgggaga aaagagacct tcagccgacc caggaaaaaa ggccaagaac ccgaagaaga    780

agaaaaagaa ggaccccaat gagccgcaga agcctgtgtc ggcctacgca ctcttcttca    840

gagacactca ggccgccatc aagggtcaga accccagtgc cactttcggt gacgtgtcca    900

aaatcgtggc ctccatgtgg gacagcctgg gagaggaaca gaagcaggcc tacaagagga    960

agacagaagc agcaaagaag gaatatctga aggccctggc agcctaccgg gctagcctcg   1020

tctccaagag ctccccagat caaggtgaga ccaagagcac tcaggcaaac ccaccagcca   1080

aaatgctccc acccaagcag cccatgtatg ccatgccagg cctggcctcc ttcctgacgc   1140

cgtcggacct gcaggccttc cgcagtgggg cctcccctgc cagcctcgcc cggacgctgg   1200

gctccaagtc tctgctgcca ggcctcagtg cgtccccgcc gccgccaccc tccttcccgc   1260

tcagccccac actgcaccag cagctgtcac tgccccctca cgcccagggc gccctcctca   1320

gtccacctgt tagcatgtcc ccagcccccc agccccctgt cctgcccacc cccatggcac   1380

tccaggtgca gctggcgatg agcccctcac ctccagggcc acaggacttc ccgcacatct   1440

ctgagttccc cagcagctcg ggatcctgct cacctggccc atccaacccc accagcagcg   1500

gggactggga cagcagctac cccagtgggg agtgtggcat cagcacctgc agcctgctcc   1560

ccagggacaa atcgctctac ctcacctaat cccgcctccc taccatccct gaggctcgct   1620

ggaaggcact gctcagagcc tgaagggctg acagcagaaa agaggccctg gccagaggca   1680

gggtggccca tcggagagag cagtgacaca cccattgccc gggggctgag tctcttcctc   1740

aacctcccac cagactctgc agaggcagcc cactgcccac caccagccca aagaacctgc   1800

aggaaccttc cgcccgctga cctgcttgct ccagggtaac tgtggaccct gtcctcgccc   1860

tgcgcacggt accctatgtc tggacacccg gccccagctc cagccccagc ccaggtgggc   1920

cgcccctggc ggggtcgctt accaacggac acccacccca gatgcatggg ccagagggcc   1980

ggcccccggc atagatgtgc acatcggttt tccagtgtga acaaaagatt acgaaaccta   2040

gaaactgttg gttccgtgta agtagttgac tacgtgtttt agaactgtgc tgaagacatc   2100

tgtaagacta ttttgtgggg gaaaaaagta gtttccttta aggtaaaaag cattttatat   2160

gatccttagc acatttttaa gttttatctt aagggagacg cgcacaaaag cggctgccaa   2220

accgtttcgt catcctcaca gcaaggaccg gacgcttgct agccaccccg gagcactgct   2280

ctccttttaa tcatgtattc atctatttta aattgccggc gacgactttt gtctatttat   2340

gaagaaacct tgagaacgaa gttacagctt atcctaccgt gtgtgtggtt ttggggtttc   2400

gtttgggttt gggttcttga cgtcgtttgc agctgtttcc tggccctggc gagtgtctgt   2460

cttggtgccc agtgcttctc tcaaatctct ttataataaa acttctgaaa agctgaaaaa   2520

aaaaaaaaaa aaa                                                      2533


<210>  3931
<211>  464
<212>  PRT
<213>  Homosapiens

<400>  3931

Met Ser Asp Gly Asn Pro Glu Leu Leu Ser Thr Ser Gln Thr Tyr Asn 
1               5                   10                  15      


Gly Gln Ser Glu Asn Asn Glu Asp Tyr Glu Ile Pro Pro Ile Thr Pro 
            20                  25                  30          


Pro Asn Leu Pro Glu Pro Ser Leu Leu His Leu Gly Asp His Glu Ala 
        35                  40                  45              


Ser Tyr His Ser Leu Cys His Gly Leu Thr Pro Asn Gly Leu Leu Pro 
    50                  55                  60                  


Ala Tyr Ser Tyr Gln Ala Met Asp Leu Pro Ala Ile Met Val Ser Asn 
65                  70                  75                  80  


Met Leu Ala Gln Asp Ser His Leu Leu Ser Gly Gln Leu Pro Thr Ile 
                85                  90                  95      


Gln Glu Met Val His Ser Glu Val Ala Ala Tyr Asp Ser Gly Arg Pro 
            100                 105                 110         


Gly Pro Leu Leu Gly Arg Pro Ala Met Leu Ala Ser His Met Ser Ala 
        115                 120                 125             


Leu Ser Gln Ser Gln Leu Ile Ser Gln Met Gly Ile Arg Ser Ser Ile 
    130                 135                 140                 


Ala His Ser Ser Pro Ser Pro Pro Gly Ser Lys Ser Ala Thr Pro Ser 
145                 150                 155                 160 


Pro Ser Ser Ser Thr Gln Glu Glu Glu Ser Glu Val His Phe Lys Ile 
                165                 170                 175     


Ser Gly Glu Lys Arg Pro Ser Ala Asp Pro Gly Lys Lys Ala Lys Asn 
            180                 185                 190         


Pro Lys Lys Lys Lys Lys Lys Asp Pro Asn Glu Pro Gln Lys Pro Val 
        195                 200                 205             


Ser Ala Tyr Ala Leu Phe Phe Arg Asp Thr Gln Ala Ala Ile Lys Gly 
    210                 215                 220                 


Gln Asn Pro Ser Ala Thr Phe Gly Asp Val Ser Lys Ile Val Ala Ser 
225                 230                 235                 240 


Met Trp Asp Ser Leu Gly Glu Glu Gln Lys Gln Ala Tyr Lys Arg Lys 
                245                 250                 255     


Thr Glu Ala Ala Lys Lys Glu Tyr Leu Lys Ala Leu Ala Ala Tyr Arg 
            260                 265                 270         


Ala Ser Leu Val Ser Lys Ser Ser Pro Asp Gln Gly Glu Thr Lys Ser 
        275                 280                 285             


Thr Gln Ala Asn Pro Pro Ala Lys Met Leu Pro Pro Lys Gln Pro Met 
    290                 295                 300                 


Tyr Ala Met Pro Gly Leu Ala Ser Phe Leu Thr Pro Ser Asp Leu Gln 
305                 310                 315                 320 


Ala Phe Arg Ser Gly Ala Ser Pro Ala Ser Leu Ala Arg Thr Leu Gly 
                325                 330                 335     


Ser Lys Ser Leu Leu Pro Gly Leu Ser Ala Ser Pro Pro Pro Pro Pro 
            340                 345                 350         


Ser Phe Pro Leu Ser Pro Thr Leu His Gln Gln Leu Ser Leu Pro Pro 
        355                 360                 365             


His Ala Gln Gly Ala Leu Leu Ser Pro Pro Val Ser Met Ser Pro Ala 
    370                 375                 380                 


Pro Gln Pro Pro Val Leu Pro Thr Pro Met Ala Leu Gln Val Gln Leu 
385                 390                 395                 400 


Ala Met Ser Pro Ser Pro Pro Gly Pro Gln Asp Phe Pro His Ile Ser 
                405                 410                 415     


Glu Phe Pro Ser Ser Ser Gly Ser Cys Ser Pro Gly Pro Ser Asn Pro 
            420                 425                 430         


Thr Ser Ser Gly Asp Trp Asp Ser Ser Tyr Pro Ser Gly Glu Cys Gly 
        435                 440                 445             


Ile Ser Thr Cys Ser Leu Leu Pro Arg Asp Lys Ser Leu Tyr Leu Thr 
    450                 455                 460                 


<210>  3932
<211>  1083
<212>  DNA
<213>  Homosapiens

<400>  3932
atgagcatcc aaaagacgta tctggaggga gattttgtct ttcctgtgag cagcagcagc     60

ttcctacgga ccctgctgga gccccagctc ggatcagccc ttctgacagc aatgaatgct    120

tcgtgctgcc tgccctctgt tcagccaaca ctgcctaatg gctcggagca cctccaagcc    180

cctttcttca gcaaccagag cagcagcgcc ttctgtgagc aggtcttcat caagcccgag    240

gttttcctgt ctctgggcat cgtcagtctg ctggaaaaca tcctggttat cctggccgtg    300

gtcaggaacg gcaacctgca ctccccgatg tacttctttc tctgcagcct ggcggtggcc    360

gacatgctgg taagtgtgtc caatgccctg gagaccatca tgatcgccat cgtccacagc    420

gactacctga ccttcgagga ccagtttatc cagcacatgg acaacatctt cgactccatg    480

atctgcatct ccctggtggc ctccatctgc aacctcctgg ccatcgccgt cgacaggtac    540

gtcaccatct tttacgcgct ccgctaccac agcatcatga ccgtgaggaa ggccctcacc    600

ttgatcgtgg ccatctgggt ctgctgcggc gtctgtggcg tggtgttcat cgtctactcg    660

gagagcaaaa tggtcattgt gtgcctcatc accatgttct tcgccatgat gctcctcatg    720

ggcaccctct acgtgcacat gttcctcttt gcgcggctgc acgtcaagcg catagcagca    780

ctgccacctg ccgacggggt ggccccacag caacactcat gcatgaaggg ggcagtcacc    840

atcaccattc tcctgggcgt gttcatcttc tgctgggccc ccttcttcct ccacctggtc    900

ctcatcatca cctgccccac caacccctac tgcatctgct acactgccca cttcaacacc    960

tacctggtcc tcatcatgtg caactccgtc atcgacccac tcatctacgc tttccggagc   1020

ctggaattgc gcaacacctt tagggagatt ctctgtggct gcaacggcat gaacttggga   1080

tag                                                                 1083


<210>  3933
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  3933

Met Ser Ile Gln Lys Thr Tyr Leu Glu Gly Asp Phe Val Phe Pro Val 
1               5                   10                  15      


Ser Ser Ser Ser Phe Leu Arg Thr Leu Leu Glu Pro Gln Leu Gly Ser 
            20                  25                  30          


Ala Leu Leu Thr Ala Met Asn Ala Ser Cys Cys Leu Pro Ser Val Gln 
        35                  40                  45              


Pro Thr Leu Pro Asn Gly Ser Glu His Leu Gln Ala Pro Phe Phe Ser 
    50                  55                  60                  


Asn Gln Ser Ser Ser Ala Phe Cys Glu Gln Val Phe Ile Lys Pro Glu 
65                  70                  75                  80  


Val Phe Leu Ser Leu Gly Ile Val Ser Leu Leu Glu Asn Ile Leu Val 
                85                  90                  95      


Ile Leu Ala Val Val Arg Asn Gly Asn Leu His Ser Pro Met Tyr Phe 
            100                 105                 110         


Phe Leu Cys Ser Leu Ala Val Ala Asp Met Leu Val Ser Val Ser Asn 
        115                 120                 125             


Ala Leu Glu Thr Ile Met Ile Ala Ile Val His Ser Asp Tyr Leu Thr 
    130                 135                 140                 


Phe Glu Asp Gln Phe Ile Gln His Met Asp Asn Ile Phe Asp Ser Met 
145                 150                 155                 160 


Ile Cys Ile Ser Leu Val Ala Ser Ile Cys Asn Leu Leu Ala Ile Ala 
                165                 170                 175     


Val Asp Arg Tyr Val Thr Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile 
            180                 185                 190         


Met Thr Val Arg Lys Ala Leu Thr Leu Ile Val Ala Ile Trp Val Cys 
        195                 200                 205             


Cys Gly Val Cys Gly Val Val Phe Ile Val Tyr Ser Glu Ser Lys Met 
    210                 215                 220                 


Val Ile Val Cys Leu Ile Thr Met Phe Phe Ala Met Met Leu Leu Met 
225                 230                 235                 240 


Gly Thr Leu Tyr Val His Met Phe Leu Phe Ala Arg Leu His Val Lys 
                245                 250                 255     


Arg Ile Ala Ala Leu Pro Pro Ala Asp Gly Val Ala Pro Gln Gln His 
            260                 265                 270         


Ser Cys Met Lys Gly Ala Val Thr Ile Thr Ile Leu Leu Gly Val Phe 
        275                 280                 285             


Ile Phe Cys Trp Ala Pro Phe Phe Leu His Leu Val Leu Ile Ile Thr 
    290                 295                 300                 


Cys Pro Thr Asn Pro Tyr Cys Ile Cys Tyr Thr Ala His Phe Asn Thr 
305                 310                 315                 320 


Tyr Leu Val Leu Ile Met Cys Asn Ser Val Ile Asp Pro Leu Ile Tyr 
                325                 330                 335     


Ala Phe Arg Ser Leu Glu Leu Arg Asn Thr Phe Arg Glu Ile Leu Cys 
            340                 345                 350         


Gly Cys Asn Gly Met Asn Leu Gly 
        355                 360 


<210>  3934
<211>  3066
<212>  DNA
<213>  Homosapiens

<400>  3934
gggtcagctc cgcccaccct ccccggcctc cgcccgcctc ccgggtcagc ggcgcgggtg     60

ctgcgcctag ctgcgcacca tggccgggtt gctggcgttg ctgggtccgg caggcagggt    120

gggcgcccgg gtccggcctc gcgccacctg gctcctgggc gccaccgccc cctgcgcccc    180

gccgcccctg gccctggccc tgctcccgcc caggctagac gcccggctgc tccgcacggc    240

gcgcggggac tgccgcggcc accaggaccc cagccaggcc acggggacaa caggcagcag    300

cgtcagctgc acagaggaga aaaagcaaag caagtcacag caactgaaaa agatttttca    360

agagtatggc actgttggcg tgtcattgca cattggaatc tcattaattt ccttgggcat    420

attttacatg gttgtgtcaa gtggtgtgga catgcctgca atcctgctga aactcggatt    480

taaagagtcc ctggtacagt caaaaatggc agcaggcaca agtaccttcg tggtggccta    540

tgcaatccac aagctgtttg cgccagtgag aatcagcatt acgctagtct ctgtgccctt    600

gattgtcaga tattttcgaa aagtgggatt ttttaaacct ccagctgcaa aaccttaatg    660

aactcttcag tcgtacacac tgaaaaccta tttcttctaa attacatgat ttggattggt    720

tttagggttt tagggttgta gggtttcttt tggagaggta gggggctaat tgctatgttc    780

tcatggataa actttgccag caaaaatcag gcttttgaac aattttaatt ttttgcctca    840

taaattttgt gaatgctatt cattataggg cttgtatata taatctaaaa tgtcagcaag    900

gcatcggaga tgggttaaca tctcaaaaca aaatagccta caaatgttcc ttgtgggaga    960

ctttggcgag ggtctgtggg taaaagcacc agggggttaa tcttggctca gtttcctaaa   1020

aagcattgat taatttaact ggcttttaaa tatccccttc cgctgatatt tgttgtcagc   1080

tgcctacagt ttaatatgca gcgttcacaa aacagctgcc agtgctacaa ttaatgaagc   1140

aaaacttaat atgtaatcac aatctaaatt agcatcaata ctttgacatt cattacattg   1200

gtttggggga agaaaagtag ttctggtatg tttcattgat ccccagatac cttccaatct   1260

ggacatgatg gggctgattc cagatggttt ttctgaaatt tcattaaggt aggtcagcgt   1320

catttgtctc tgtttaggta aaatataaaa accctgccca gtagcagtgg catcgcttgg   1380

ttcctgatgc ccatgttcca gaggaattcg gataccacaa acagctaaga caatctcagc   1440

ttttcttaga caatcttcta tctcaaactt cagacattcc agaattgtca tgatgtttac   1500

actgtctgag ttaaaaatcc tgttcaagaa aaaaaaagat tttgtatcac ttcttaaaaa   1560

ggaatattca tagcacttgt cacaaataga aggcaaccat gagataatac aagccaggga   1620

gaggcttgta ttacatgaca ggtgtaatta gtctgctgag ccagctttac ccaatgaagg   1680

gcatatgtgt tagagagatt agctaagagt agaaattcga gcatagaggc caggtgcggt   1740

ggctcacgcc tgtaatccca gcactttggg aggttgaggc aggcgtgtca cttgaggcca   1800

ggagttcgag accagcctgg ccaacatgat gaaaccccgt ctctactaca aatacaaaaa   1860

ttagccgggt gtggtggcac acgcctgtag tcccagctac tggggaggct gaggcagcat   1920

tgcttgaacc caggaggtgg aggttgcagt gagccaagat cacaccactg cactccagcc   1980

tgggcgacag agggagacac tgtctccaaa agaaagaaat cccagcgtag atccaaactg   2040

agacactgag gcttcgtcct tatagtagtc aggagcaggc gattgaagta attctgtcct   2100

gcggggttca gcatcatgca cgttccccct gggccattct ctgatgcagg gcacttgctc   2160

cacactctgg gaacccagat tcaccagtct gccctgtcac gtagttgaag gagttgcatt   2220

tatctttctg gctcctaatt cctttaaaat tacatttgtt gcagaacctc cacaaggcta   2280

aataaaatta catttgtgac catcagagaa ctgaataaac cattaactgg ccatcctggt   2340

tttgcagaga tcaggttgtt gacagttcct ggttgaccca cagctaccca tgtcagttat   2400

ctccactaac atatccaaga atctttgtag gacaatttct ccacctgcaa ggtctttcag   2460

gtagaactct tcttttaagg caattagccc attgccaaaa ggttttactg tcttaaagct   2520

gtctttctga gatctaattc caaggacttc tccacagcta agtgagatgc ctcacaccat   2580

taggtgatgc tttggacaga acagagtatt ttcatcttgt gtttaaagca attccttggc   2640

ttcggctcct caccactttc tatgccagtc tcccatttat gtccctagta atgcctatgc   2700

aaaaaaaaaa aaagaaaaaa aagaaaaact gatggtgaaa cctacaggtt taagggctta   2760

aatctcaaac tttgttagga gtaacaggag cgtgctgagc gggcaagcaa taaaacaaat   2820

cataccaaaa agccacattg ctctctccta agccccaacc ccactccact cctgtggcca   2880

ggggtccaaa cagaaaataa ccggagaaga caaggaggtc aaaggatcag ggaactaagc   2940

attatgtgaa ttcaccagca agatgtacag aacgcctgtg tttacattgt ttttatggaa   3000

ctagcagaat aaaacatcta ttttaaaaat gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3060

aaaaaa                                                              3066


<210>  3935
<211>  192
<212>  PRT
<213>  Homosapiens

<400>  3935

Met Ala Gly Leu Leu Ala Leu Leu Gly Pro Ala Gly Arg Val Gly Ala 
1               5                   10                  15      


Arg Val Arg Pro Arg Ala Thr Trp Leu Leu Gly Ala Thr Ala Pro Cys 
            20                  25                  30          


Ala Pro Pro Pro Leu Ala Leu Ala Leu Leu Pro Pro Arg Leu Asp Ala 
        35                  40                  45              


Arg Leu Leu Arg Thr Ala Arg Gly Asp Cys Arg Gly His Gln Asp Pro 
    50                  55                  60                  


Ser Gln Ala Thr Gly Thr Thr Gly Ser Ser Val Ser Cys Thr Glu Glu 
65                  70                  75                  80  


Lys Lys Gln Ser Lys Ser Gln Gln Leu Lys Lys Ile Phe Gln Glu Tyr 
                85                  90                  95      


Gly Thr Val Gly Val Ser Leu His Ile Gly Ile Ser Leu Ile Ser Leu 
            100                 105                 110         


Gly Ile Phe Tyr Met Val Val Ser Ser Gly Val Asp Met Pro Ala Ile 
        115                 120                 125             


Leu Leu Lys Leu Gly Phe Lys Glu Ser Leu Val Gln Ser Lys Met Ala 
    130                 135                 140                 


Ala Gly Thr Ser Thr Phe Val Val Ala Tyr Ala Ile His Lys Leu Phe 
145                 150                 155                 160 


Ala Pro Val Arg Ile Ser Ile Thr Leu Val Ser Val Pro Leu Ile Val 
                165                 170                 175     


Arg Tyr Phe Arg Lys Val Gly Phe Phe Lys Pro Pro Ala Ala Lys Pro 
            180                 185                 190         


<210>  3936
<211>  2346
<212>  DNA
<213>  Homosapiens

<400>  3936
acaaggcagc ctcgctcgag cgcaggccaa tcggctttct agctagaggg tttaactcct     60

atttaaaaag aagaaccttt gaattctaac ggctgagctc ttggaagact tgggtccttg    120

ggtcgcaggt gggagccgac gggtgggtag accgtggggg atatctcagt ggcggacgag    180

gacggcgggg acaaggggcg gctggtcgga gtggcggagc gtcaagtccc ctgtcggttc    240

ctccgtccct gagtgtcctt ggcgctgcct tgtgcccgcc cagcgccttt gcatccgctc    300

ctgggcaccg aggcgccctg taggatactg cttgttactt attacagcta gaggcatcat    360

ggaccgatct aaagaaaact gcatttcagg acctgttaag gctacagctc cagttggagg    420

tccaaaacgt gttctcgtga ctcagcaatt tccttgtcag aatccattac ctgtaaatag    480

tggccaggct cagcgggtct tgtgtccttc aaattcttcc cagcgcattc ctttgcaagc    540

acaaaagctt gtctccagtc acaagccggt tcagaatcag aagcagaagc aattgcaggc    600

aaccagtgta cctcatcctg tctccaggcc actgaataac acccaaaaga gcaagcagcc    660

cctgccatcg gcacctgaaa ataatcctga ggaggaactg gcatcaaaac agaaaaatga    720

agaatcaaaa aagaggcagt gggctttgga agactttgaa attggtcgcc ctctgggtaa    780

aggaaagttt ggtaatgttt atttggcaag agaaaagcaa agcaagttta ttctggctct    840

taaagtgtta tttaaagctc agctggagaa agccggagtg gagcatcagc tcagaagaga    900

agtagaaata cagtcccacc ttcggcatcc taatattctt agactgtatg gttatttcca    960

tgatgctacc agagtctacc taattctgga atatgcacca cttggaacag tttatagaga   1020

acttcagaaa ctttcaaagt ttgatgagca gagaactgct acttatataa cagaattggc   1080

aaatgccctg tcttactgtc attcgaagag agttattcat agagacatta agccagagaa   1140

cttacttctt ggatcagctg gagagcttaa aattgcagat tttgggtggt cagtacatgc   1200

tccatcttcc aggaggacca ctctctgtgg caccctggac tacctgcccc ctgaaatgat   1260

tgaaggtcgg atgcatgatg agaaggtgga tctctggagc cttggagttc tttgctatga   1320

atttttagtt gggaagcctc cttttgaggc aaacacatac caagagacct acaaaagaat   1380

atcacgggtt gaattcacat tccctgactt tgtaacagag ggagccaggg acctcatttc   1440

aagactgttg aagcataatc ccagccagag gccaatgctc agagaagtac ttgaacaccc   1500

ctggatcaca gcaaattcat caaaaccatc aaattgccaa aacaaagaat cagctagcaa   1560

acagtcttag gaatcgtgca gggggagaaa tccttgagcc agggctgcca tataacctga   1620

caggaacatg ctactgaagt ttattttacc attgactgct gccctcaatc tagaacgcta   1680

cacaagaaat atttgtttta ctcagcaggt gtgccttaac ctccctattc agaaagctcc   1740

acatcaataa acatgacact ctgaagtgaa agtagccacg agaattgtgc tacttatact   1800

ggttcataat ctggaggcaa ggttcgactg cagccgcccc gtcagcctgt gctaggcatg   1860

gtgtcttcac aggaggcaaa tccagagcct ggctgtgggg aaagtgacca ctctgccctg   1920

accccgatca gttaaggagc tgtgcaataa ccttcctagt acctgagtga gtgtgtaact   1980

tattgggttg gcgaagcctg gtaaagctgt tggaatgagt atgtgattct ttttaagtat   2040

gaaaataaag atatatgtac agacttgtat tttttctctg gtggcattcc tttaggaatg   2100

ctgtgtgtct gtccggcacc ccggtaggcc tgattgggtt tctagtcctc cttaaccact   2160

tatctcccat atgagagtgt gaaaaatagg aacacgtgct ctacctccat ttagggattt   2220

gcttgggata cagaagaggc catgtgtctc agagctgtta agggcttatt tttttaaaac   2280

attggagtca tagcatgtgt gtaaacttta aatatgcaaa taaataagta tctatgtcta   2340

aaaaaa                                                              2346


<210>  3937
<211>  403
<212>  PRT
<213>  Homosapiens

<400>  3937

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  3938
<211>  2554
<212>  DNA
<213>  Homosapiens

<400>  3938
acaaggcagc ctcgctcgag cgcaggccaa tcggctttct agctagaggg tttaactcct     60

atttaaaaag aagaaccttt gaattctaac ggctgagctc ttggaagact tgggtccttg    120

ggtcgcaggt gggagccgac gggtgggtag accgtggggg atatctcagt ggcggacgag    180

gacggcgggg acaaggggcg gctggtcgga gtggcggagc gtcaagtccc ctgtcggttc    240

ctccgtccct gagtgtcctt ggcgctgcct tgtgcccgcc cagcgccttt gcatccgctc    300

ctgggcaccg aggcgccctg taggatactg cttgttactt attacagcta gagggtctca    360

ctccattgcc caggccagag tgcggggata tttgataaga aacttcagtg aaggccgggc    420

gcggtggctc atgcccgtaa tcccagcatt ttcggaggcc gaggctggag tgcaatggtg    480

tgatctcagc tcactgcaac ctctgcttcc tgggtttaag tgattctcct gcctcagcct    540

cccgagtagc tgggattaca ggcatcatgg accgatctaa agaaaactgc atttcaggac    600

ctgttaaggc tacagctcca gttggaggtc caaaacgtgt tctcgtgact cagcaatttc    660

cttgtcagaa tccattacct gtaaatagtg gccaggctca gcgggtcttg tgtccttcaa    720

attcttccca gcgcattcct ttgcaagcac aaaagcttgt ctccagtcac aagccggttc    780

agaatcagaa gcagaagcaa ttgcaggcaa ccagtgtacc tcatcctgtc tccaggccac    840

tgaataacac ccaaaagagc aagcagcccc tgccatcggc acctgaaaat aatcctgagg    900

aggaactggc atcaaaacag aaaaatgaag aatcaaaaaa gaggcagtgg gctttggaag    960

actttgaaat tggtcgccct ctgggtaaag gaaagtttgg taatgtttat ttggcaagag   1020

aaaagcaaag caagtttatt ctggctctta aagtgttatt taaagctcag ctggagaaag   1080

ccggagtgga gcatcagctc agaagagaag tagaaataca gtcccacctt cggcatccta   1140

atattcttag actgtatggt tatttccatg atgctaccag agtctaccta attctggaat   1200

atgcaccact tggaacagtt tatagagaac ttcagaaact ttcaaagttt gatgagcaga   1260

gaactgctac ttatataaca gaattggcaa atgccctgtc ttactgtcat tcgaagagag   1320

ttattcatag agacattaag ccagagaact tacttcttgg atcagctgga gagcttaaaa   1380

ttgcagattt tgggtggtca gtacatgctc catcttccag gaggaccact ctctgtggca   1440

ccctggacta cctgccccct gaaatgattg aaggtcggat gcatgatgag aaggtggatc   1500

tctggagcct tggagttctt tgctatgaat ttttagttgg gaagcctcct tttgaggcaa   1560

acacatacca agagacctac aaaagaatat cacgggttga attcacattc cctgactttg   1620

taacagaggg agccagggac ctcatttcaa gactgttgaa gcataatccc agccagaggc   1680

caatgctcag agaagtactt gaacacccct ggatcacagc aaattcatca aaaccatcaa   1740

attgccaaaa caaagaatca gctagcaaac agtcttagga atcgtgcagg gggagaaatc   1800

cttgagccag ggctgccata taacctgaca ggaacatgct actgaagttt attttaccat   1860

tgactgctgc cctcaatcta gaacgctaca caagaaatat ttgttttact cagcaggtgt   1920

gccttaacct ccctattcag aaagctccac atcaataaac atgacactct gaagtgaaag   1980

tagccacgag aattgtgcta cttatactgg ttcataatct ggaggcaagg ttcgactgca   2040

gccgccccgt cagcctgtgc taggcatggt gtcttcacag gaggcaaatc cagagcctgg   2100

ctgtggggaa agtgaccact ctgccctgac cccgatcagt taaggagctg tgcaataacc   2160

ttcctagtac ctgagtgagt gtgtaactta ttgggttggc gaagcctggt aaagctgttg   2220

gaatgagtat gtgattcttt ttaagtatga aaataaagat atatgtacag acttgtattt   2280

tttctctggt ggcattcctt taggaatgct gtgtgtctgt ccggcacccc ggtaggcctg   2340

attgggtttc tagtcctcct taaccactta tctcccatat gagagtgtga aaaataggaa   2400

cacgtgctct acctccattt agggatttgc ttgggataca gaagaggcca tgtgtctcag   2460

agctgttaag ggcttatttt tttaaaacat tggagtcata gcatgtgtgt aaactttaaa   2520

tatgcaaata aataagtatc tatgtctaaa aaaa                               2554


<210>  3939
<211>  403
<212>  PRT
<213>  Homosapiens

<400>  3939

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  3940
<211>  2245
<212>  DNA
<213>  Homosapiens

<400>  3940
acaaggcagc ctcgctcgag cgcaggccaa tcggctttct agctagaggg tttaactcct     60

atttaaaaag aagaaccttt gaattctaac ggctgagctc ttggaagact tgggtccttg    120

ggtcgcaggt gggagccgac ggggtctcac tccattgccc aggccagagt gcggggatat    180

ttgataagaa acttcagtga aggccgggcg cggtggctca tgcccgtaat cccagcattt    240

tcggaggccg aggcatcatg gaccgatcta aagaaaactg catttcagga cctgttaagg    300

ctacagctcc agttggaggt ccaaaacgtg ttctcgtgac tcagcaattt ccttgtcaga    360

atccattacc tgtaaatagt ggccaggctc agcgggtctt gtgtccttca aattcttccc    420

agcgcattcc tttgcaagca caaaagcttg tctccagtca caagccggtt cagaatcaga    480

agcagaagca attgcaggca accagtgtac ctcatcctgt ctccaggcca ctgaataaca    540

cccaaaagag caagcagccc ctgccatcgg cacctgaaaa taatcctgag gaggaactgg    600

catcaaaaca gaaaaatgaa gaatcaaaaa agaggcagtg ggctttggaa gactttgaaa    660

ttggtcgccc tctgggtaaa ggaaagtttg gtaatgttta tttggcaaga gaaaagcaaa    720

gcaagtttat tctggctctt aaagtgttat ttaaagctca gctggagaaa gccggagtgg    780

agcatcagct cagaagagaa gtagaaatac agtcccacct tcggcatcct aatattctta    840

gactgtatgg ttatttccat gatgctacca gagtctacct aattctggaa tatgcaccac    900

ttggaacagt ttatagagaa cttcagaaac tttcaaagtt tgatgagcag agaactgcta    960

cttatataac agaattggca aatgccctgt cttactgtca ttcgaagaga gttattcata   1020

gagacattaa gccagagaac ttacttcttg gatcagctgg agagcttaaa attgcagatt   1080

ttgggtggtc agtacatgct ccatcttcca ggaggaccac tctctgtggc accctggact   1140

acctgccccc tgaaatgatt gaaggtcgga tgcatgatga gaaggtggat ctctggagcc   1200

ttggagttct ttgctatgaa tttttagttg ggaagcctcc ttttgaggca aacacatacc   1260

aagagaccta caaaagaata tcacgggttg aattcacatt ccctgacttt gtaacagagg   1320

gagccaggga cctcatttca agactgttga agcataatcc cagccagagg ccaatgctca   1380

gagaagtact tgaacacccc tggatcacag caaattcatc aaaaccatca aattgccaaa   1440

acaaagaatc agctagcaaa cagtcttagg aatcgtgcag ggggagaaat ccttgagcca   1500

gggctgccat ataacctgac aggaacatgc tactgaagtt tattttacca ttgactgctg   1560

ccctcaatct agaacgctac acaagaaata tttgttttac tcagcaggtg tgccttaacc   1620

tccctattca gaaagctcca catcaataaa catgacactc tgaagtgaaa gtagccacga   1680

gaattgtgct acttatactg gttcataatc tggaggcaag gttcgactgc agccgccccg   1740

tcagcctgtg ctaggcatgg tgtcttcaca ggaggcaaat ccagagcctg gctgtgggga   1800

aagtgaccac tctgccctga ccccgatcag ttaaggagct gtgcaataac cttcctagta   1860

cctgagtgag tgtgtaactt attgggttgg cgaagcctgg taaagctgtt ggaatgagta   1920

tgtgattctt tttaagtatg aaaataaaga tatatgtaca gacttgtatt ttttctctgg   1980

tggcattcct ttaggaatgc tgtgtgtctg tccggcaccc cggtaggcct gattgggttt   2040

ctagtcctcc ttaaccactt atctcccata tgagagtgtg aaaaatagga acacgtgctc   2100

tacctccatt tagggatttg cttgggatac agaagaggcc atgtgtctca gagctgttaa   2160

gggcttattt ttttaaaaca ttggagtcat agcatgtgtg taaactttaa atatgcaaat   2220

aaataagtat ctatgtctaa aaaaa                                         2245


<210>  3941
<211>  403
<212>  PRT
<213>  Homosapiens

<400>  3941

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  3942
<211>  2135
<212>  DNA
<213>  Homosapiens

<400>  3942
acaaggcagc ctcgctcgag cgcaggccaa tcggctttct agctagaggg tttaactcct     60

atttaaaaag aagaaccttt gaattctaac ggctgagctc ttggaagact tgggtccttg    120

ggtcgcaggt gggagccgac gggcatcatg gaccgatcta aagaaaactg catttcagga    180

cctgttaagg ctacagctcc agttggaggt ccaaaacgtg ttctcgtgac tcagcaattt    240

ccttgtcaga atccattacc tgtaaatagt ggccaggctc agcgggtctt gtgtccttca    300

aattcttccc agcgcattcc tttgcaagca caaaagcttg tctccagtca caagccggtt    360

cagaatcaga agcagaagca attgcaggca accagtgtac ctcatcctgt ctccaggcca    420

ctgaataaca cccaaaagag caagcagccc ctgccatcgg cacctgaaaa taatcctgag    480

gaggaactgg catcaaaaca gaaaaatgaa gaatcaaaaa agaggcagtg ggctttggaa    540

gactttgaaa ttggtcgccc tctgggtaaa ggaaagtttg gtaatgttta tttggcaaga    600

gaaaagcaaa gcaagtttat tctggctctt aaagtgttat ttaaagctca gctggagaaa    660

gccggagtgg agcatcagct cagaagagaa gtagaaatac agtcccacct tcggcatcct    720

aatattctta gactgtatgg ttatttccat gatgctacca gagtctacct aattctggaa    780

tatgcaccac ttggaacagt ttatagagaa cttcagaaac tttcaaagtt tgatgagcag    840

agaactgcta cttatataac agaattggca aatgccctgt cttactgtca ttcgaagaga    900

gttattcata gagacattaa gccagagaac ttacttcttg gatcagctgg agagcttaaa    960

attgcagatt ttgggtggtc agtacatgct ccatcttcca ggaggaccac tctctgtggc   1020

accctggact acctgccccc tgaaatgatt gaaggtcgga tgcatgatga gaaggtggat   1080

ctctggagcc ttggagttct ttgctatgaa tttttagttg ggaagcctcc ttttgaggca   1140

aacacatacc aagagaccta caaaagaata tcacgggttg aattcacatt ccctgacttt   1200

gtaacagagg gagccaggga cctcatttca agactgttga agcataatcc cagccagagg   1260

ccaatgctca gagaagtact tgaacacccc tggatcacag caaattcatc aaaaccatca   1320

aattgccaaa acaaagaatc agctagcaaa cagtcttagg aatcgtgcag ggggagaaat   1380

ccttgagcca gggctgccat ataacctgac aggaacatgc tactgaagtt tattttacca   1440

ttgactgctg ccctcaatct agaacgctac acaagaaata tttgttttac tcagcaggtg   1500

tgccttaacc tccctattca gaaagctcca catcaataaa catgacactc tgaagtgaaa   1560

gtagccacga gaattgtgct acttatactg gttcataatc tggaggcaag gttcgactgc   1620

agccgccccg tcagcctgtg ctaggcatgg tgtcttcaca ggaggcaaat ccagagcctg   1680

gctgtgggga aagtgaccac tctgccctga ccccgatcag ttaaggagct gtgcaataac   1740

cttcctagta cctgagtgag tgtgtaactt attgggttgg cgaagcctgg taaagctgtt   1800

ggaatgagta tgtgattctt tttaagtatg aaaataaaga tatatgtaca gacttgtatt   1860

ttttctctgg tggcattcct ttaggaatgc tgtgtgtctg tccggcaccc cggtaggcct   1920

gattgggttt ctagtcctcc ttaaccactt atctcccata tgagagtgtg aaaaatagga   1980

acacgtgctc tacctccatt tagggatttg cttgggatac agaagaggcc atgtgtctca   2040

gagctgttaa gggcttattt ttttaaaaca ttggagtcat agcatgtgtg taaactttaa   2100

atatgcaaat aaataagtat ctatgtctaa aaaaa                              2135


<210>  3943
<211>  403
<212>  PRT
<213>  Homosapiens

<400>  3943

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  3944
<211>  2231
<212>  DNA
<213>  Homosapiens

<400>  3944
acaaggcagc ctcgctcgag cgcaggccaa tcggctttct agctagaggg tttaactcct     60

atttaaaaag aagaaccttt gaattctaac ggctgagctc ttggaagact tgggtccttg    120

ggtcgcaggg tctcactcca ttgcccaggc cagagtgcgg ggatatttga taagaaactt    180

cagtgaaggc cgggcgcggt ggctcatgcc cgtaatccca gcattttcgg aggccgaggc    240

atcatggacc gatctaaaga aaactgcatt tcaggacctg ttaaggctac agctccagtt    300

ggaggtccaa aacgtgttct cgtgactcag caatttcctt gtcagaatcc attacctgta    360

aatagtggcc aggctcagcg ggtcttgtgt ccttcaaatt cttcccagcg cattcctttg    420

caagcacaaa agcttgtctc cagtcacaag ccggttcaga atcagaagca gaagcaattg    480

caggcaacca gtgtacctca tcctgtctcc aggccactga ataacaccca aaagagcaag    540

cagcccctgc catcggcacc tgaaaataat cctgaggagg aactggcatc aaaacagaaa    600

aatgaagaat caaaaaagag gcagtgggct ttggaagact ttgaaattgg tcgccctctg    660

ggtaaaggaa agtttggtaa tgtttatttg gcaagagaaa agcaaagcaa gtttattctg    720

gctcttaaag tgttatttaa agctcagctg gagaaagccg gagtggagca tcagctcaga    780

agagaagtag aaatacagtc ccaccttcgg catcctaata ttcttagact gtatggttat    840

ttccatgatg ctaccagagt ctacctaatt ctggaatatg caccacttgg aacagtttat    900

agagaacttc agaaactttc aaagtttgat gagcagagaa ctgctactta tataacagaa    960

ttggcaaatg ccctgtctta ctgtcattcg aagagagtta ttcatagaga cattaagcca   1020

gagaacttac ttcttggatc agctggagag cttaaaattg cagattttgg gtggtcagta   1080

catgctccat cttccaggag gaccactctc tgtggcaccc tggactacct gccccctgaa   1140

atgattgaag gtcggatgca tgatgagaag gtggatctct ggagccttgg agttctttgc   1200

tatgaatttt tagttgggaa gcctcctttt gaggcaaaca cataccaaga gacctacaaa   1260

agaatatcac gggttgaatt cacattccct gactttgtaa cagagggagc cagggacctc   1320

atttcaagac tgttgaagca taatcccagc cagaggccaa tgctcagaga agtacttgaa   1380

cacccctgga tcacagcaaa ttcatcaaaa ccatcaaatt gccaaaacaa agaatcagct   1440

agcaaacagt cttaggaatc gtgcaggggg agaaatcctt gagccagggc tgccatataa   1500

cctgacagga acatgctact gaagtttatt ttaccattga ctgctgccct caatctagaa   1560

cgctacacaa gaaatatttg ttttactcag caggtgtgcc ttaacctccc tattcagaaa   1620

gctccacatc aataaacatg acactctgaa gtgaaagtag ccacgagaat tgtgctactt   1680

atactggttc ataatctgga ggcaaggttc gactgcagcc gccccgtcag cctgtgctag   1740

gcatggtgtc ttcacaggag gcaaatccag agcctggctg tggggaaagt gaccactctg   1800

ccctgacccc gatcagttaa ggagctgtgc aataaccttc ctagtacctg agtgagtgtg   1860

taacttattg ggttggcgaa gcctggtaaa gctgttggaa tgagtatgtg attcttttta   1920

agtatgaaaa taaagatata tgtacagact tgtatttttt ctctggtggc attcctttag   1980

gaatgctgtg tgtctgtccg gcaccccggt aggcctgatt gggtttctag tcctccttaa   2040

ccacttatct cccatatgag agtgtgaaaa ataggaacac gtgctctacc tccatttagg   2100

gatttgcttg ggatacagaa gaggccatgt gtctcagagc tgttaagggc ttattttttt   2160

aaaacattgg agtcatagca tgtgtgtaaa ctttaaatat gcaaataaat aagtatctat   2220

gtctaaaaaa a                                                        2231


<210>  3945
<211>  403
<212>  PRT
<213>  Homosapiens

<400>  3945

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  3946
<211>  2121
<212>  DNA
<213>  Homosapiens

<400>  3946
acaaggcagc ctcgctcgag cgcaggccaa tcggctttct agctagaggg tttaactcct     60

atttaaaaag aagaaccttt gaattctaac ggctgagctc ttggaagact tgggtccttg    120

ggtcgcaggc atcatggacc gatctaaaga aaactgcatt tcaggacctg ttaaggctac    180

agctccagtt ggaggtccaa aacgtgttct cgtgactcag caatttcctt gtcagaatcc    240

attacctgta aatagtggcc aggctcagcg ggtcttgtgt ccttcaaatt cttcccagcg    300

cattcctttg caagcacaaa agcttgtctc cagtcacaag ccggttcaga atcagaagca    360

gaagcaattg caggcaacca gtgtacctca tcctgtctcc aggccactga ataacaccca    420

aaagagcaag cagcccctgc catcggcacc tgaaaataat cctgaggagg aactggcatc    480

aaaacagaaa aatgaagaat caaaaaagag gcagtgggct ttggaagact ttgaaattgg    540

tcgccctctg ggtaaaggaa agtttggtaa tgtttatttg gcaagagaaa agcaaagcaa    600

gtttattctg gctcttaaag tgttatttaa agctcagctg gagaaagccg gagtggagca    660

tcagctcaga agagaagtag aaatacagtc ccaccttcgg catcctaata ttcttagact    720

gtatggttat ttccatgatg ctaccagagt ctacctaatt ctggaatatg caccacttgg    780

aacagtttat agagaacttc agaaactttc aaagtttgat gagcagagaa ctgctactta    840

tataacagaa ttggcaaatg ccctgtctta ctgtcattcg aagagagtta ttcatagaga    900

cattaagcca gagaacttac ttcttggatc agctggagag cttaaaattg cagattttgg    960

gtggtcagta catgctccat cttccaggag gaccactctc tgtggcaccc tggactacct   1020

gccccctgaa atgattgaag gtcggatgca tgatgagaag gtggatctct ggagccttgg   1080

agttctttgc tatgaatttt tagttgggaa gcctcctttt gaggcaaaca cataccaaga   1140

gacctacaaa agaatatcac gggttgaatt cacattccct gactttgtaa cagagggagc   1200

cagggacctc atttcaagac tgttgaagca taatcccagc cagaggccaa tgctcagaga   1260

agtacttgaa cacccctgga tcacagcaaa ttcatcaaaa ccatcaaatt gccaaaacaa   1320

agaatcagct agcaaacagt cttaggaatc gtgcaggggg agaaatcctt gagccagggc   1380

tgccatataa cctgacagga acatgctact gaagtttatt ttaccattga ctgctgccct   1440

caatctagaa cgctacacaa gaaatatttg ttttactcag caggtgtgcc ttaacctccc   1500

tattcagaaa gctccacatc aataaacatg acactctgaa gtgaaagtag ccacgagaat   1560

tgtgctactt atactggttc ataatctgga ggcaaggttc gactgcagcc gccccgtcag   1620

cctgtgctag gcatggtgtc ttcacaggag gcaaatccag agcctggctg tggggaaagt   1680

gaccactctg ccctgacccc gatcagttaa ggagctgtgc aataaccttc ctagtacctg   1740

agtgagtgtg taacttattg ggttggcgaa gcctggtaaa gctgttggaa tgagtatgtg   1800

attcttttta agtatgaaaa taaagatata tgtacagact tgtatttttt ctctggtggc   1860

attcctttag gaatgctgtg tgtctgtccg gcaccccggt aggcctgatt gggtttctag   1920

tcctccttaa ccacttatct cccatatgag agtgtgaaaa ataggaacac gtgctctacc   1980

tccatttagg gatttgcttg ggatacagaa gaggccatgt gtctcagagc tgttaagggc   2040

ttattttttt aaaacattgg agtcatagca tgtgtgtaaa ctttaaatat gcaaataaat   2100

aagtatctat gtctaaaaaa a                                             2121


<210>  3947
<211>  403
<212>  PRT
<213>  Homosapiens

<400>  3947

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  3948
<211>  2295
<212>  DNA
<213>  Homosapiens

<400>  3948
aagaacccgg aagtggtgga gccaacggcc agccagacct gtggcagtcc cagccccagg     60

gtgctctccg cggtcggcca tttatcggtg aagcaacagc cccttgacgt caagcttgac    120

gcattggaga taaagtccaa ggaggtgaac taacctttga acgtgccact ggcagggaaa    180

ctgtcttcct tttctccaag atgtacagaa ccaaagtggg cttgaaggac cgccagcagc    240

tctacaagct gatcattagc cagctgctat atgacggcta catcagcatc gccaatggcc    300

tcatcaatga aatcaagcct cagtctgtgt gtgcaccctc ggagcagctc ctgcatctca    360

tcaaactcgg aatggaaaac gatgacaccg cagttcagta tgcaattggt cgttcagata    420

ctgttgcccc tggcacaggg attgacctgg aatttgatgc agatgttcag actatgtccc    480

cagaggcttc tgagtacgaa acatgctatg tcacatcaca taaaggacca tgccgtgtag    540

ctacctatag tagagatgga cagttaatag ctactgggtc tgctgatgct tcgataaaga    600

tacttgacac agagaggatg ttggccaaaa gtgccatgcc aatagaggtc atgatgaatg    660

agaccgcaca acaaaatatg gaaaaccacc cagtgattcg aactctttat gaccatgtgg    720

atgaagtcac gtgccttgct ttccacccaa cagaacagat cctggcttct ggttcaaggg    780

attatactct taaattattt gattattcca aaccatcagc aaaaagagcc ttcaaataca    840

ttcaggaagc tgaaatgtta cgttccatct cttttcatcc ttctggagac tttatacttg    900

tcggaactca gcatcctact cttcgccttt atgatatcaa cacctttcaa tgttttgtct    960

cttgcaatcc tcaagatcaa cacaccgatg ctatatgttc cgttaattac aattctagtg   1020

ccaatatgta cgtaactgga agcaaggacg gctgcatcaa attatgggat ggtgtttcaa   1080

atcgatgcat cacaactttt gagaaagcac atgacggtgc tgaagtttgt tctgccattt   1140

tttccaaaaa ttctaaatac attctctcaa gtggaaaaga ctctgtagct aaactttggg   1200

aaatatcaac gggacgaaca ctggtcagat acacgggcgc gggtttaagt ggacgccagg   1260

tgcaccggac acaggctgtg tttaaccaca ccgaggacta tgtgttgctg cccgacgaga   1320

ggacgatcag tctttgctgc tgggactcga ggacagccga gcggagaaac ctgctgtcgt   1380

tggggcacaa caatattgta cgctgcatag tgcactcccc caccaacccc gggttcatga   1440

cgtgcagcga tgacttcaga gcgcggtttt ggtaccggag atcgaccact gactgagcca   1500

ccctctccgt agggttcttt ctcgaggact ctaccctcct cccccacgtc ctgtctcagc   1560

tgcagtcgta agtccgtgca ccatccttga cgttttgctg ccacctctgt ccacattctt   1620

cttggatttg tataaaagaa tcttttttta ccttgatgta gaatcatggt ggaaaaagtt   1680

ggaaacacag atctgtgcag ttctacattc actgattatt acagtgtgat tttcatcggt   1740

tttgtaagta caggacttgc cgtttctttt gatctcttga ttgaaggagg atagggcatt   1800

aaagtgcttt tgacatgagg aattttcatt tggttcttct gtcaactttc ttgcttattc   1860

tgctgaaccc tctgtgtatt tcccttccag gtatatttga acagataagc aggcatgcag   1920

ctctgagact cctgagtttt atgccattat caaaagcatt ttcaagaatc cctcaattct   1980

atcctgaaat gatgttattc tgataataaa gctcagatct gcaactttat tgttatatat   2040

ttttcacttc tgtaaaatta atggccagtt tttcctgaca atttatagga acagtatctt   2100

tcaacatact ccctacatta tccttcaata tctgcaatac ttgtctttag taactgtatt   2160

tctggtaaga ttatgatttc atgagaaaca attgaaaata tatccgatct aattaaatta   2220

ggtcagcctg ctattgctct caggtgttgc ctgtcttcac gaatgattag tatcgattga   2280

cctctttctt aggtg                                                    2295


<210>  3949
<211>  431
<212>  PRT
<213>  Homosapiens

<400>  3949

Met Tyr Arg Thr Lys Val Gly Leu Lys Asp Arg Gln Gln Leu Tyr Lys 
1               5                   10                  15      


Leu Ile Ile Ser Gln Leu Leu Tyr Asp Gly Tyr Ile Ser Ile Ala Asn 
            20                  25                  30          


Gly Leu Ile Asn Glu Ile Lys Pro Gln Ser Val Cys Ala Pro Ser Glu 
        35                  40                  45              


Gln Leu Leu His Leu Ile Lys Leu Gly Met Glu Asn Asp Asp Thr Ala 
    50                  55                  60                  


Val Gln Tyr Ala Ile Gly Arg Ser Asp Thr Val Ala Pro Gly Thr Gly 
65                  70                  75                  80  


Ile Asp Leu Glu Phe Asp Ala Asp Val Gln Thr Met Ser Pro Glu Ala 
                85                  90                  95      


Ser Glu Tyr Glu Thr Cys Tyr Val Thr Ser His Lys Gly Pro Cys Arg 
            100                 105                 110         


Val Ala Thr Tyr Ser Arg Asp Gly Gln Leu Ile Ala Thr Gly Ser Ala 
        115                 120                 125             


Asp Ala Ser Ile Lys Ile Leu Asp Thr Glu Arg Met Leu Ala Lys Ser 
    130                 135                 140                 


Ala Met Pro Ile Glu Val Met Met Asn Glu Thr Ala Gln Gln Asn Met 
145                 150                 155                 160 


Glu Asn His Pro Val Ile Arg Thr Leu Tyr Asp His Val Asp Glu Val 
                165                 170                 175     


Thr Cys Leu Ala Phe His Pro Thr Glu Gln Ile Leu Ala Ser Gly Ser 
            180                 185                 190         


Arg Asp Tyr Thr Leu Lys Leu Phe Asp Tyr Ser Lys Pro Ser Ala Lys 
        195                 200                 205             


Arg Ala Phe Lys Tyr Ile Gln Glu Ala Glu Met Leu Arg Ser Ile Ser 
    210                 215                 220                 


Phe His Pro Ser Gly Asp Phe Ile Leu Val Gly Thr Gln His Pro Thr 
225                 230                 235                 240 


Leu Arg Leu Tyr Asp Ile Asn Thr Phe Gln Cys Phe Val Ser Cys Asn 
                245                 250                 255     


Pro Gln Asp Gln His Thr Asp Ala Ile Cys Ser Val Asn Tyr Asn Ser 
            260                 265                 270         


Ser Ala Asn Met Tyr Val Thr Gly Ser Lys Asp Gly Cys Ile Lys Leu 
        275                 280                 285             


Trp Asp Gly Val Ser Asn Arg Cys Ile Thr Thr Phe Glu Lys Ala His 
    290                 295                 300                 


Asp Gly Ala Glu Val Cys Ser Ala Ile Phe Ser Lys Asn Ser Lys Tyr 
305                 310                 315                 320 


Ile Leu Ser Ser Gly Lys Asp Ser Val Ala Lys Leu Trp Glu Ile Ser 
                325                 330                 335     


Thr Gly Arg Thr Leu Val Arg Tyr Thr Gly Ala Gly Leu Ser Gly Arg 
            340                 345                 350         


Gln Val His Arg Thr Gln Ala Val Phe Asn His Thr Glu Asp Tyr Val 
        355                 360                 365             


Leu Leu Pro Asp Glu Arg Thr Ile Ser Leu Cys Cys Trp Asp Ser Arg 
    370                 375                 380                 


Thr Ala Glu Arg Arg Asn Leu Leu Ser Leu Gly His Asn Asn Ile Val 
385                 390                 395                 400 


Arg Cys Ile Val His Ser Pro Thr Asn Pro Gly Phe Met Thr Cys Ser 
                405                 410                 415     


Asp Asp Phe Arg Ala Arg Phe Trp Tyr Arg Arg Ser Thr Thr Asp 
            420                 425                 430     


<210>  3950
<211>  2292
<212>  DNA
<213>  Homosapiens

<400>  3950
ggcaggattc gcgcctccat ttttccagga gagagcggga taccaagaga accggaccag     60

ctggtactgg gacacgggga gagtagctgg tgcggtcggc tggggcattt agagaaaacc    120

acagaaacga ctggggcgag actggaagag tcgagagtta gcaagctggc agggaaactg    180

tcttcctttt ctccaagatg tacagaacca aagtgggctt gaaggaccgc cagcagctct    240

acaagctgat cattagccag ctgctatatg acggctacat cagcatcgcc aatggcctca    300

tcaatgaaat caagcctcag tctgtgtgtg caccctcgga gcagctcctg catctcatca    360

aactcggaat ggaaaacgat gacaccgcag ttcagtatgc aattggtcgt tcagatactg    420

ttgcccctgg cacagggatt gacctggaat ttgatgcaga tgttcagact atgtccccag    480

aggcttctga gtacgaaaca tgctatgtca catcacataa aggaccatgc cgtgtagcta    540

cctatagtag agatggacag ttaatagcta ctgggtctgc tgatgcttcg ataaagatac    600

ttgacacaga gaggatgttg gccaaaagtg ccatgccaat agaggtcatg atgaatgaga    660

ccgcacaaca aaatatggaa aaccacccag tgattcgaac tctttatgac catgtggatg    720

aagtcacgtg ccttgctttc cacccaacag aacagatcct ggcttctggt tcaagggatt    780

atactcttaa attatttgat tattccaaac catcagcaaa aagagccttc aaatacattc    840

aggaagctga aatgttacgt tccatctctt ttcatccttc tggagacttt atacttgtcg    900

gaactcagca tcctactctt cgcctttatg atatcaacac ctttcaatgt tttgtctctt    960

gcaatcctca agatcaacac accgatgcta tatgttccgt taattacaat tctagtgcca   1020

atatgtacgt aactggaagc aaggacggct gcatcaaatt atgggatggt gtttcaaatc   1080

gatgcatcac aacttttgag aaagcacatg acggtgctga agtttgttct gccatttttt   1140

ccaaaaattc taaatacatt ctctcaagtg gaaaagactc tgtagctaaa ctttgggaaa   1200

tatcaacggg acgaacactg gtcagataca cgggcgcggg tttaagtgga cgccaggtgc   1260

accggacaca ggctgtgttt aaccacaccg aggactatgt gttgctgccc gacgagagga   1320

cgatcagtct ttgctgctgg gactcgagga cagccgagcg gagaaacctg ctgtcgttgg   1380

ggcacaacaa tattgtacgc tgcatagtgc actcccccac caaccccggg ttcatgacgt   1440

gcagcgatga cttcagagcg cggttttggt accggagatc gaccactgac tgagccaccc   1500

tctccgtagg gttctttctc gaggactcta ccctcctccc ccacgtcctg tctcagctgc   1560

agtcgtaagt ccgtgcacca tccttgacgt tttgctgcca cctctgtcca cattcttctt   1620

ggatttgtat aaaagaatct ttttttacct tgatgtagaa tcatggtgga aaaagttgga   1680

aacacagatc tgtgcagttc tacattcact gattattaca gtgtgatttt catcggtttt   1740

gtaagtacag gacttgccgt ttcttttgat ctcttgattg aaggaggata gggcattaaa   1800

gtgcttttga catgaggaat tttcatttgg ttcttctgtc aactttcttg cttattctgc   1860

tgaaccctct gtgtatttcc cttccaggta tatttgaaca gataagcagg catgcagctc   1920

tgagactcct gagttttatg ccattatcaa aagcattttc aagaatccct caattctatc   1980

ctgaaatgat gttattctga taataaagct cagatctgca actttattgt tatatatttt   2040

tcacttctgt aaaattaatg gccagttttt cctgacaatt tataggaaca gtatctttca   2100

acatactccc tacattatcc ttcaatatct gcaatacttg tctttagtaa ctgtatttct   2160

ggtaagatta tgatttcatg agaaacaatt gaaaatatat ccgatctaat taaattaggt   2220

cagcctgcta ttgctctcag gtgttgcctg tcttcacgaa tgattagtat cgattgacct   2280

ctttcttagg tg                                                       2292


<210>  3951
<211>  431
<212>  PRT
<213>  Homosapiens

<400>  3951

Met Tyr Arg Thr Lys Val Gly Leu Lys Asp Arg Gln Gln Leu Tyr Lys 
1               5                   10                  15      


Leu Ile Ile Ser Gln Leu Leu Tyr Asp Gly Tyr Ile Ser Ile Ala Asn 
            20                  25                  30          


Gly Leu Ile Asn Glu Ile Lys Pro Gln Ser Val Cys Ala Pro Ser Glu 
        35                  40                  45              


Gln Leu Leu His Leu Ile Lys Leu Gly Met Glu Asn Asp Asp Thr Ala 
    50                  55                  60                  


Val Gln Tyr Ala Ile Gly Arg Ser Asp Thr Val Ala Pro Gly Thr Gly 
65                  70                  75                  80  


Ile Asp Leu Glu Phe Asp Ala Asp Val Gln Thr Met Ser Pro Glu Ala 
                85                  90                  95      


Ser Glu Tyr Glu Thr Cys Tyr Val Thr Ser His Lys Gly Pro Cys Arg 
            100                 105                 110         


Val Ala Thr Tyr Ser Arg Asp Gly Gln Leu Ile Ala Thr Gly Ser Ala 
        115                 120                 125             


Asp Ala Ser Ile Lys Ile Leu Asp Thr Glu Arg Met Leu Ala Lys Ser 
    130                 135                 140                 


Ala Met Pro Ile Glu Val Met Met Asn Glu Thr Ala Gln Gln Asn Met 
145                 150                 155                 160 


Glu Asn His Pro Val Ile Arg Thr Leu Tyr Asp His Val Asp Glu Val 
                165                 170                 175     


Thr Cys Leu Ala Phe His Pro Thr Glu Gln Ile Leu Ala Ser Gly Ser 
            180                 185                 190         


Arg Asp Tyr Thr Leu Lys Leu Phe Asp Tyr Ser Lys Pro Ser Ala Lys 
        195                 200                 205             


Arg Ala Phe Lys Tyr Ile Gln Glu Ala Glu Met Leu Arg Ser Ile Ser 
    210                 215                 220                 


Phe His Pro Ser Gly Asp Phe Ile Leu Val Gly Thr Gln His Pro Thr 
225                 230                 235                 240 


Leu Arg Leu Tyr Asp Ile Asn Thr Phe Gln Cys Phe Val Ser Cys Asn 
                245                 250                 255     


Pro Gln Asp Gln His Thr Asp Ala Ile Cys Ser Val Asn Tyr Asn Ser 
            260                 265                 270         


Ser Ala Asn Met Tyr Val Thr Gly Ser Lys Asp Gly Cys Ile Lys Leu 
        275                 280                 285             


Trp Asp Gly Val Ser Asn Arg Cys Ile Thr Thr Phe Glu Lys Ala His 
    290                 295                 300                 


Asp Gly Ala Glu Val Cys Ser Ala Ile Phe Ser Lys Asn Ser Lys Tyr 
305                 310                 315                 320 


Ile Leu Ser Ser Gly Lys Asp Ser Val Ala Lys Leu Trp Glu Ile Ser 
                325                 330                 335     


Thr Gly Arg Thr Leu Val Arg Tyr Thr Gly Ala Gly Leu Ser Gly Arg 
            340                 345                 350         


Gln Val His Arg Thr Gln Ala Val Phe Asn His Thr Glu Asp Tyr Val 
        355                 360                 365             


Leu Leu Pro Asp Glu Arg Thr Ile Ser Leu Cys Cys Trp Asp Ser Arg 
    370                 375                 380                 


Thr Ala Glu Arg Arg Asn Leu Leu Ser Leu Gly His Asn Asn Ile Val 
385                 390                 395                 400 


Arg Cys Ile Val His Ser Pro Thr Asn Pro Gly Phe Met Thr Cys Ser 
                405                 410                 415     


Asp Asp Phe Arg Ala Arg Phe Trp Tyr Arg Arg Ser Thr Thr Asp 
            420                 425                 430     


<210>  3952
<211>  2323
<212>  DNA
<213>  Homosapiens

<400>  3952
aactaacctt tgaacgtgcc agtaagtaag atggcgagaa aagcaagaga gagtgggacc     60

gatcgatagc gcagcggtcg gcttggcgcc ctttcagcgt gcgcagtgaa cgtgcgctcg    120

gagcggtaga ttgggcagga ttcgcgcctc catttttcca ggagagagcg ggataccaag    180

agaaccggac cagctgctgg cagggaaact gtcttccttt tctccaagat gtacagaacc    240

aaagtgggct tgaaggaccg ccagcagctc tacaagctga tcattagcca gctgctatat    300

gacggctaca tcagcatcgc caatggcctc atcaatgaaa tcaagcctca gtctgtgtgt    360

gcaccctcgg agcagctcct gcatctcatc aaactcggaa tggaaaacga tgacaccgca    420

gttcagtatg caattggtcg ttcagatact gttgcccctg gcacagggat tgacctggaa    480

tttgatgcag atgttcagac tatgtcccca gaggcttctg agtacgaaac atgctatgtc    540

acatcacata aaggaccatg ccgtgtagct acctatagta gagatggaca gttaatagct    600

actgggtctg ctgatgcttc gataaagata cttgacacag agaggatgtt ggccaaaagt    660

gccatgccaa tagaggtcat gatgaatgag accgcacaac aaaatatgga aaaccaccca    720

gtgattcgaa ctctttatga ccatgtggat gaagtcacgt gccttgcttt ccacccaaca    780

gaacagatcc tggcttctgg ttcaagggat tatactctta aattatttga ttattccaaa    840

ccatcagcaa aaagagcctt caaatacatt caggaagctg aaatgttacg ttccatctct    900

tttcatcctt ctggagactt tatacttgtc ggaactcagc atcctactct tcgcctttat    960

gatatcaaca cctttcaatg ttttgtctct tgcaatcctc aagatcaaca caccgatgct   1020

atatgttccg ttaattacaa ttctagtgcc aatatgtacg taactggaag caaggacggc   1080

tgcatcaaat tatgggatgg tgtttcaaat cgatgcatca caacttttga gaaagcacat   1140

gacggtgctg aagtttgttc tgccattttt tccaaaaatt ctaaatacat tctctcaagt   1200

ggaaaagact ctgtagctaa actttgggaa atatcaacgg gacgaacact ggtcagatac   1260

acgggcgcgg gtttaagtgg acgccaggtg caccggacac aggctgtgtt taaccacacc   1320

gaggactatg tgttgctgcc cgacgagagg acgatcagtc tttgctgctg ggactcgagg   1380

acagccgagc ggagaaacct gctgtcgttg gggcacaaca atattgtacg ctgcatagtg   1440

cactccccca ccaaccccgg gttcatgacg tgcagcgatg acttcagagc gcggttttgg   1500

taccggagat cgaccactga ctgagccacc ctctccgtag ggttctttct cgaggactct   1560

accctcctcc cccacgtcct gtctcagctg cagtcgtaag tccgtgcacc atccttgacg   1620

ttttgctgcc acctctgtcc acattcttct tggatttgta taaaagaatc tttttttacc   1680

ttgatgtaga atcatggtgg aaaaagttgg aaacacagat ctgtgcagtt ctacattcac   1740

tgattattac agtgtgattt tcatcggttt tgtaagtaca ggacttgccg tttcttttga   1800

tctcttgatt gaaggaggat agggcattaa agtgcttttg acatgaggaa ttttcatttg   1860

gttcttctgt caactttctt gcttattctg ctgaaccctc tgtgtatttc ccttccaggt   1920

atatttgaac agataagcag gcatgcagct ctgagactcc tgagttttat gccattatca   1980

aaagcatttt caagaatccc tcaattctat cctgaaatga tgttattctg ataataaagc   2040

tcagatctgc aactttattg ttatatattt ttcacttctg taaaattaat ggccagtttt   2100

tcctgacaat ttataggaac agtatctttc aacatactcc ctacattatc cttcaatatc   2160

tgcaatactt gtctttagta actgtatttc tggtaagatt atgatttcat gagaaacaat   2220

tgaaaatata tccgatctaa ttaaattagg tcagcctgct attgctctca ggtgttgcct   2280

gtcttcacga atgattagta tcgattgacc tctttcttag gtg                     2323


<210>  3953
<211>  431
<212>  PRT
<213>  Homosapiens

<400>  3953

Met Tyr Arg Thr Lys Val Gly Leu Lys Asp Arg Gln Gln Leu Tyr Lys 
1               5                   10                  15      


Leu Ile Ile Ser Gln Leu Leu Tyr Asp Gly Tyr Ile Ser Ile Ala Asn 
            20                  25                  30          


Gly Leu Ile Asn Glu Ile Lys Pro Gln Ser Val Cys Ala Pro Ser Glu 
        35                  40                  45              


Gln Leu Leu His Leu Ile Lys Leu Gly Met Glu Asn Asp Asp Thr Ala 
    50                  55                  60                  


Val Gln Tyr Ala Ile Gly Arg Ser Asp Thr Val Ala Pro Gly Thr Gly 
65                  70                  75                  80  


Ile Asp Leu Glu Phe Asp Ala Asp Val Gln Thr Met Ser Pro Glu Ala 
                85                  90                  95      


Ser Glu Tyr Glu Thr Cys Tyr Val Thr Ser His Lys Gly Pro Cys Arg 
            100                 105                 110         


Val Ala Thr Tyr Ser Arg Asp Gly Gln Leu Ile Ala Thr Gly Ser Ala 
        115                 120                 125             


Asp Ala Ser Ile Lys Ile Leu Asp Thr Glu Arg Met Leu Ala Lys Ser 
    130                 135                 140                 


Ala Met Pro Ile Glu Val Met Met Asn Glu Thr Ala Gln Gln Asn Met 
145                 150                 155                 160 


Glu Asn His Pro Val Ile Arg Thr Leu Tyr Asp His Val Asp Glu Val 
                165                 170                 175     


Thr Cys Leu Ala Phe His Pro Thr Glu Gln Ile Leu Ala Ser Gly Ser 
            180                 185                 190         


Arg Asp Tyr Thr Leu Lys Leu Phe Asp Tyr Ser Lys Pro Ser Ala Lys 
        195                 200                 205             


Arg Ala Phe Lys Tyr Ile Gln Glu Ala Glu Met Leu Arg Ser Ile Ser 
    210                 215                 220                 


Phe His Pro Ser Gly Asp Phe Ile Leu Val Gly Thr Gln His Pro Thr 
225                 230                 235                 240 


Leu Arg Leu Tyr Asp Ile Asn Thr Phe Gln Cys Phe Val Ser Cys Asn 
                245                 250                 255     


Pro Gln Asp Gln His Thr Asp Ala Ile Cys Ser Val Asn Tyr Asn Ser 
            260                 265                 270         


Ser Ala Asn Met Tyr Val Thr Gly Ser Lys Asp Gly Cys Ile Lys Leu 
        275                 280                 285             


Trp Asp Gly Val Ser Asn Arg Cys Ile Thr Thr Phe Glu Lys Ala His 
    290                 295                 300                 


Asp Gly Ala Glu Val Cys Ser Ala Ile Phe Ser Lys Asn Ser Lys Tyr 
305                 310                 315                 320 


Ile Leu Ser Ser Gly Lys Asp Ser Val Ala Lys Leu Trp Glu Ile Ser 
                325                 330                 335     


Thr Gly Arg Thr Leu Val Arg Tyr Thr Gly Ala Gly Leu Ser Gly Arg 
            340                 345                 350         


Gln Val His Arg Thr Gln Ala Val Phe Asn His Thr Glu Asp Tyr Val 
        355                 360                 365             


Leu Leu Pro Asp Glu Arg Thr Ile Ser Leu Cys Cys Trp Asp Ser Arg 
    370                 375                 380                 


Thr Ala Glu Arg Arg Asn Leu Leu Ser Leu Gly His Asn Asn Ile Val 
385                 390                 395                 400 


Arg Cys Ile Val His Ser Pro Thr Asn Pro Gly Phe Met Thr Cys Ser 
                405                 410                 415     


Asp Asp Phe Arg Ala Arg Phe Trp Tyr Arg Arg Ser Thr Thr Asp 
            420                 425                 430     


<210>  3954
<211>  2545
<212>  DNA
<213>  Homosapiens

<400>  3954
ctttttgatc gtttcccatg tgttgtcaga tagctccata gaattcagtt tctgagaacc     60

agccagaagc atgcagtgac attgcacaat ctgcctctga agctggagat actagctgca    120

gagctcaggg gagctgctcc acatcaccga catgaaggga acaggcatca tggactgtgc    180

gcccaaggca ctcctggcca gggcacttta tgacaactgc cctgactgct ctgacgagct    240

ggctttcagc agaggggaca tcctgaccat tctggagcaa cacgtgccag aaagcgaggg    300

ttggtggaag tgtttgctcc atgggaggca aggcctggcc cctgccaacc gcctccaaat    360

cctcacggag gtcgctgcag acaggccgtg ccccccattc ctgagaggcc tggaagaagc    420

tcctgccagc tcagaggaga cctatcaggt gcccactcta ccccgccctc ccactccagg    480

ccccgtttat gagcagatga ggagttgggc ggaggggccc cagcccccta ctgcccaagt    540

ctatgaattc cccgaccctc ccaccagtgc cagaatcatc tgtgaaaaga ctctcagctt    600

tccaaaacag gccatcctca cgcttcccag acctgtccgg gcctcactgc cgactctgcc    660

ttcccaggtg tatgacgtgc ctacccagca ccggggcccc gtggtcctga aggagccaga    720

gaagcagcag ttatatgaca taccagccag ccccaagaag gcaggactcc atcccccaga    780

cagccaagca agtgggcagg gtgttcccct gatatcagtg actaccttaa gaagaggcgg    840

ttacagcaca ttaccaaatc ctcagaaatc ggaatggatt tatgacactc cagtgtctcc    900

aggaaaggcc agcgtcagaa acacgcctct caccagcttt gcggaagaat caaggcccca    960

cgctctcccc agttccagct ccactttcta caatcctcca agtggcagat ccaggtccct   1020

cactccacaa ctgaataaca atgtgcccat gcagaaaaaa ctcagccttc cagaaattcc   1080

ttcttatggc tttcttgtac ccagaggcac atttcctttg gatgaagatg tcagctacaa   1140

ggttccttca agctttctga ttccccgagt ggaacagcag aacaccaagc ccaatattta   1200

tgacatccct aaagcaacgt cgagtgtttc tcaggctggg aaggagctgg agaaagccaa   1260

ggaggtgtca gagaattccg cgggccataa ttcctcatgg ttctccagac ggacaacttc   1320

cccatctcct gaaccggaca gattatcagg ttccagttct gacagcagag ctagcatcgt   1380

ttcctcgtgc tccaccacat ccaccgacga ctcctccagc tcttcctcgg aggagtcagc   1440

aaaggagctc tccttggacc tggatgtggc caaggagaca gtgatggctc tgcagcacaa   1500

ggtggtcagc tctgtcgctg gcctgatgct ctttgtcagc aggaagtgga gattccgaga   1560

ctatctggag gccaacattg atgcaatcca caggtccact gatcacatag aagaatctgt   1620

aagagaattt ctggattttg cccgaggagt ccatgggact gcctgtaacc tcactgacag   1680

taaccttcag aacagaattc gggaccagat gcagaccatc tccaactcct accgcatcct   1740

gcttgaaaca aaggaaagct tggataatcg caattggcct ctggaagttc ttgtgactga   1800

cagtgtccag aacagcccag atgaccttga gaggtttgtc atggtggcac ggatgcttcc   1860

agaagacatc aagaggtttg cctccattgt cattgccaat ggaaggctcc tttttaagcg   1920

gaactgtgaa aaggaagaga ctgtgcagtt gaccccaaat gcagaattta agtgtgaaaa   1980

atacatccag cctccccaaa gagaaactga atcacaccaa aagagtaccc cttccactaa   2040

gcaaagggaa gatgaacact cttctgaact attaaagaaa aatagggcaa atatctgtgg   2100

acagaatcct ggccctctta tacctcagcc ttcgagtcaa cagactcctg agaggaaacc   2160

ccgcttatct gaacactgcc ggctgtactt tggggcgctc ttcaaagcca tcagcgcatt   2220

tcacggcagc ctcagcagca gccagcccgc ggagatcatc actcagagca agctggtcat   2280

catggtggga cagaagctgg tggacacgct gtgcatggag acccaggaga gggacgtgcg   2340

caatgagatc ctccgcggca gcagtcacct ctgcagcctg ctcaaggacg tagcgctggc   2400

cactaagaat gccgtgctca cataccccag ccctgccgcg ctggggcacc tccaggcgga   2460

ggctgagaag ctggagcaac acacgcggca gttcagaggg acactgggat gaggactgtc   2520

tacctccctt cctcctctgc tcacc                                         2545


<210>  3955
<211>  786
<212>  PRT
<213>  Homosapiens

<400>  3955

Met Lys Gly Thr Gly Ile Met Asp Cys Ala Pro Lys Ala Leu Leu Ala 
1               5                   10                  15      


Arg Ala Leu Tyr Asp Asn Cys Pro Asp Cys Ser Asp Glu Leu Ala Phe 
            20                  25                  30          


Ser Arg Gly Asp Ile Leu Thr Ile Leu Glu Gln His Val Pro Glu Ser 
        35                  40                  45              


Glu Gly Trp Trp Lys Cys Leu Leu His Gly Arg Gln Gly Leu Ala Pro 
    50                  55                  60                  


Ala Asn Arg Leu Gln Ile Leu Thr Glu Val Ala Ala Asp Arg Pro Cys 
65                  70                  75                  80  


Pro Pro Phe Leu Arg Gly Leu Glu Glu Ala Pro Ala Ser Ser Glu Glu 
                85                  90                  95      


Thr Tyr Gln Val Pro Thr Leu Pro Arg Pro Pro Thr Pro Gly Pro Val 
            100                 105                 110         


Tyr Glu Gln Met Arg Ser Trp Ala Glu Gly Pro Gln Pro Pro Thr Ala 
        115                 120                 125             


Gln Val Tyr Glu Phe Pro Asp Pro Pro Thr Ser Ala Arg Ile Ile Cys 
    130                 135                 140                 


Glu Lys Thr Leu Ser Phe Pro Lys Gln Ala Ile Leu Thr Leu Pro Arg 
145                 150                 155                 160 


Pro Val Arg Ala Ser Leu Pro Thr Leu Pro Ser Gln Val Tyr Asp Val 
                165                 170                 175     


Pro Thr Gln His Arg Gly Pro Val Val Leu Lys Glu Pro Glu Lys Gln 
            180                 185                 190         


Gln Leu Tyr Asp Ile Pro Ala Ser Pro Lys Lys Ala Gly Leu His Pro 
        195                 200                 205             


Pro Asp Ser Gln Ala Ser Gly Gln Gly Val Pro Leu Ile Ser Val Thr 
    210                 215                 220                 


Thr Leu Arg Arg Gly Gly Tyr Ser Thr Leu Pro Asn Pro Gln Lys Ser 
225                 230                 235                 240 


Glu Trp Ile Tyr Asp Thr Pro Val Ser Pro Gly Lys Ala Ser Val Arg 
                245                 250                 255     


Asn Thr Pro Leu Thr Ser Phe Ala Glu Glu Ser Arg Pro His Ala Leu 
            260                 265                 270         


Pro Ser Ser Ser Ser Thr Phe Tyr Asn Pro Pro Ser Gly Arg Ser Arg 
        275                 280                 285             


Ser Leu Thr Pro Gln Leu Asn Asn Asn Val Pro Met Gln Lys Lys Leu 
    290                 295                 300                 


Ser Leu Pro Glu Ile Pro Ser Tyr Gly Phe Leu Val Pro Arg Gly Thr 
305                 310                 315                 320 


Phe Pro Leu Asp Glu Asp Val Ser Tyr Lys Val Pro Ser Ser Phe Leu 
                325                 330                 335     


Ile Pro Arg Val Glu Gln Gln Asn Thr Lys Pro Asn Ile Tyr Asp Ile 
            340                 345                 350         


Pro Lys Ala Thr Ser Ser Val Ser Gln Ala Gly Lys Glu Leu Glu Lys 
        355                 360                 365             


Ala Lys Glu Val Ser Glu Asn Ser Ala Gly His Asn Ser Ser Trp Phe 
    370                 375                 380                 


Ser Arg Arg Thr Thr Ser Pro Ser Pro Glu Pro Asp Arg Leu Ser Gly 
385                 390                 395                 400 


Ser Ser Ser Asp Ser Arg Ala Ser Ile Val Ser Ser Cys Ser Thr Thr 
                405                 410                 415     


Ser Thr Asp Asp Ser Ser Ser Ser Ser Ser Glu Glu Ser Ala Lys Glu 
            420                 425                 430         


Leu Ser Leu Asp Leu Asp Val Ala Lys Glu Thr Val Met Ala Leu Gln 
        435                 440                 445             


His Lys Val Val Ser Ser Val Ala Gly Leu Met Leu Phe Val Ser Arg 
    450                 455                 460                 


Lys Trp Arg Phe Arg Asp Tyr Leu Glu Ala Asn Ile Asp Ala Ile His 
465                 470                 475                 480 


Arg Ser Thr Asp His Ile Glu Glu Ser Val Arg Glu Phe Leu Asp Phe 
                485                 490                 495     


Ala Arg Gly Val His Gly Thr Ala Cys Asn Leu Thr Asp Ser Asn Leu 
            500                 505                 510         


Gln Asn Arg Ile Arg Asp Gln Met Gln Thr Ile Ser Asn Ser Tyr Arg 
        515                 520                 525             


Ile Leu Leu Glu Thr Lys Glu Ser Leu Asp Asn Arg Asn Trp Pro Leu 
    530                 535                 540                 


Glu Val Leu Val Thr Asp Ser Val Gln Asn Ser Pro Asp Asp Leu Glu 
545                 550                 555                 560 


Arg Phe Val Met Val Ala Arg Met Leu Pro Glu Asp Ile Lys Arg Phe 
                565                 570                 575     


Ala Ser Ile Val Ile Ala Asn Gly Arg Leu Leu Phe Lys Arg Asn Cys 
            580                 585                 590         


Glu Lys Glu Glu Thr Val Gln Leu Thr Pro Asn Ala Glu Phe Lys Cys 
        595                 600                 605             


Glu Lys Tyr Ile Gln Pro Pro Gln Arg Glu Thr Glu Ser His Gln Lys 
    610                 615                 620                 


Ser Thr Pro Ser Thr Lys Gln Arg Glu Asp Glu His Ser Ser Glu Leu 
625                 630                 635                 640 


Leu Lys Lys Asn Arg Ala Asn Ile Cys Gly Gln Asn Pro Gly Pro Leu 
                645                 650                 655     


Ile Pro Gln Pro Ser Ser Gln Gln Thr Pro Glu Arg Lys Pro Arg Leu 
            660                 665                 670         


Ser Glu His Cys Arg Leu Tyr Phe Gly Ala Leu Phe Lys Ala Ile Ser 
        675                 680                 685             


Ala Phe His Gly Ser Leu Ser Ser Ser Gln Pro Ala Glu Ile Ile Thr 
    690                 695                 700                 


Gln Ser Lys Leu Val Ile Met Val Gly Gln Lys Leu Val Asp Thr Leu 
705                 710                 715                 720 


Cys Met Glu Thr Gln Glu Arg Asp Val Arg Asn Glu Ile Leu Arg Gly 
                725                 730                 735     


Ser Ser His Leu Cys Ser Leu Leu Lys Asp Val Ala Leu Ala Thr Lys 
            740                 745                 750         


Asn Ala Val Leu Thr Tyr Pro Ser Pro Ala Ala Leu Gly His Leu Gln 
        755                 760                 765             


Ala Glu Ala Glu Lys Leu Glu Gln His Thr Arg Gln Phe Arg Gly Thr 
    770                 775                 780                 


Leu Gly 
785     


<210>  3956
<211>  1639
<212>  DNA
<213>  Homosapiens

<400>  3956
gggatttcgc gggaaatccc ggaagtgaca gctttggggg tttgctgctg gctctgactc     60

ccgtcctgcg atgggttgcg acgggggaac aatccccaag aggcatgaac tggtgaaggg    120

gccgaagaag gttgagaagg tcgacaaaga tgctgaatta gtggcccaat ggaactattg    180

tactctaagt caggaaatat taagacgacc aatagttgcc tgtgaacttg gcagacttta    240

taacaaagat gccgtcattg aatttctctt ggacaaatct gcagaaaagg ctcttgggaa    300

ggcagcatct cacattaaaa gcattaagaa tgtgacagag ctgaagcttt ctgataatcc    360

tgcctgggaa ggggataaag gaaacactaa aggtgacaag cacgatgacc tccagcgggc    420

gcgtttcatc tgccccgttg tgggcctgga gatgaacggc cgacacaggt tctgcttcct    480

tcggtgctgc ggctgtgtgt tttctgagcg agccttgaaa gagataaaag cggaagtttg    540

ccacacgtgt ggggctgcct tccaggagga tgatgtcatc gtgctcaatg gcaccaagga    600

ggatgtggac gtgctgaaga caaggatgga ggagagaagg ctgagagcga agctggaaaa    660

gaaaccaaag aaacccaagg cagcagagtc tgcttcaaaa ccagatgtca gtgaagaagc    720

cccagggcca tcaaaagtta agacagggaa gcctgaagaa gccagccttg attctagaga    780

gaagaaaacc aacttggctc ccaaaagcac agcaatgaat gagagctctt ctggaaaagc    840

tgggaagcct ccgtgtggag ccacaaagag gtccatcgct gacagtgaag aatcggaggc    900

ctacaagtcc ctctttacca ctcacagctc cgccaagcgc tccaaggagg agtctgccca    960

ctgggtcacc cacacgtcct actgcttctg aagcccgcac tgccaccgct cctgccccag   1020

aaggttgttt agtttccacg taggcaggtc gctttgtgcc tctgagtgcg ctgctgtgtg   1080

ttctctctat agttctgtgt cataaagctg tcctgggcca gccttcaagc tgggtgttgg   1140

ccactcttga tgtgaggcgt gtcggttcca ggggggacat gggaggggct gcacagtggc   1200

ccgaggtcat gcttgcttcc acctgcaggt gcatttggtc ctttccatgg ccaggaagcc   1260

ctgtgggctg cactttttat gcttgcagta acaagagact ccagagtcct caccggtgca   1320

gagttggcac atattaatta actaaaattc taatgatctt gctaccagca ataaatcaag   1380

taggccaagt gaaactgggc tttaaaaagg atggatttca aatacactgt gcccactaga   1440

agcttcgaag ggcctcgtcc ctctgctaca gccctgggag gagccaggat ccttgttggt   1500

ctagctaaat actgttaggg gagtgtgccc catctcatca tttcgaagat agcagagtca   1560

tagttgggca cccagtgatt gggttcaaaa ataaagctgg tctgcctctc caaaaaaaaa   1620

aaaaaaaaaa aaaaaaaaa                                                1639


<210>  3957
<211>  306
<212>  PRT
<213>  Homosapiens

<400>  3957

Met Gly Cys Asp Gly Gly Thr Ile Pro Lys Arg His Glu Leu Val Lys 
1               5                   10                  15      


Gly Pro Lys Lys Val Glu Lys Val Asp Lys Asp Ala Glu Leu Val Ala 
            20                  25                  30          


Gln Trp Asn Tyr Cys Thr Leu Ser Gln Glu Ile Leu Arg Arg Pro Ile 
        35                  40                  45              


Val Ala Cys Glu Leu Gly Arg Leu Tyr Asn Lys Asp Ala Val Ile Glu 
    50                  55                  60                  


Phe Leu Leu Asp Lys Ser Ala Glu Lys Ala Leu Gly Lys Ala Ala Ser 
65                  70                  75                  80  


His Ile Lys Ser Ile Lys Asn Val Thr Glu Leu Lys Leu Ser Asp Asn 
                85                  90                  95      


Pro Ala Trp Glu Gly Asp Lys Gly Asn Thr Lys Gly Asp Lys His Asp 
            100                 105                 110         


Asp Leu Gln Arg Ala Arg Phe Ile Cys Pro Val Val Gly Leu Glu Met 
        115                 120                 125             


Asn Gly Arg His Arg Phe Cys Phe Leu Arg Cys Cys Gly Cys Val Phe 
    130                 135                 140                 


Ser Glu Arg Ala Leu Lys Glu Ile Lys Ala Glu Val Cys His Thr Cys 
145                 150                 155                 160 


Gly Ala Ala Phe Gln Glu Asp Asp Val Ile Val Leu Asn Gly Thr Lys 
                165                 170                 175     


Glu Asp Val Asp Val Leu Lys Thr Arg Met Glu Glu Arg Arg Leu Arg 
            180                 185                 190         


Ala Lys Leu Glu Lys Lys Pro Lys Lys Pro Lys Ala Ala Glu Ser Ala 
        195                 200                 205             


Ser Lys Pro Asp Val Ser Glu Glu Ala Pro Gly Pro Ser Lys Val Lys 
    210                 215                 220                 


Thr Gly Lys Pro Glu Glu Ala Ser Leu Asp Ser Arg Glu Lys Lys Thr 
225                 230                 235                 240 


Asn Leu Ala Pro Lys Ser Thr Ala Met Asn Glu Ser Ser Ser Gly Lys 
                245                 250                 255     


Ala Gly Lys Pro Pro Cys Gly Ala Thr Lys Arg Ser Ile Ala Asp Ser 
            260                 265                 270         


Glu Glu Ser Glu Ala Tyr Lys Ser Leu Phe Thr Thr His Ser Ser Ala 
        275                 280                 285             


Lys Arg Ser Lys Glu Glu Ser Ala His Trp Val Thr His Thr Ser Tyr 
    290                 295                 300                 


Cys Phe 
305     


<210>  3958
<211>  905
<212>  DNA
<213>  Homosapiens

<400>  3958
aaaacaaaaa catgatggcc tctcccagca aagctccagg gttggaaaga gtcccctggc     60

agggaattgg caccccgtcg tgcccatcct ctctctctga ctgcctgctg gaaatgcccc    120

catctccctt tgagtcctcc tcccgggcaa cccctgtgac ctgtaacctc tgtcctgaaa    180

tcatcacaat ggccagagtg gcctcagctc agggcctctg tgacatcacc aagggcctgg    240

caccaggtgc ccagtctccc agttgcgagg gcaagcaaac ccgtcatgag caactccctt    300

ccccatctct gctcaccatg tggacgctga aatcgtccct ggtcctgctt ctgtgcctca    360

cctgcagcta tgcctttatg ttctcttctc tgagacagaa aactagcgaa ccccagggga    420

aggtgcaata cggagagcac tttcggattc ggcagaatct accagagcac acccaaggct    480

ggcttgggag caaatggctc tggcttcttt ttgttgttgt gccgtttgtg atactgcagt    540

gtcaaagaga cagtgagaag aataaggagc agagtcctcc tggccttcga ggcggccaac    600

ttcactctcc attaaagaaa aaaagaaatg cttcccccaa caaagactgt gcattcaata    660

ccttaatgga actcgaggtg gagcttatga aatttgtgtc caaagtgcgg aatcttaaac    720

gtgccatggc aacaggtagt ggcagtaacc tcaggcttcg aaagtcagag atgcctgcag    780

atccatacca tgtcacgatc tgtgaaatat ggggagaaga aagctctagc tgaatggatt    840

tgtgtgtcag gagagaaaaa agttgagtgt tgacaaactg tatgcaaact aataaaacta    900

ttctg                                                                905


<210>  3959
<211>  171
<212>  PRT
<213>  Homosapiens

<400>  3959

Met Trp Thr Leu Lys Ser Ser Leu Val Leu Leu Leu Cys Leu Thr Cys 
1               5                   10                  15      


Ser Tyr Ala Phe Met Phe Ser Ser Leu Arg Gln Lys Thr Ser Glu Pro 
            20                  25                  30          


Gln Gly Lys Val Gln Tyr Gly Glu His Phe Arg Ile Arg Gln Asn Leu 
        35                  40                  45              


Pro Glu His Thr Gln Gly Trp Leu Gly Ser Lys Trp Leu Trp Leu Leu 
    50                  55                  60                  


Phe Val Val Val Pro Phe Val Ile Leu Gln Cys Gln Arg Asp Ser Glu 
65                  70                  75                  80  


Lys Asn Lys Glu Gln Ser Pro Pro Gly Leu Arg Gly Gly Gln Leu His 
                85                  90                  95      


Ser Pro Leu Lys Lys Lys Arg Asn Ala Ser Pro Asn Lys Asp Cys Ala 
            100                 105                 110         


Phe Asn Thr Leu Met Glu Leu Glu Val Glu Leu Met Lys Phe Val Ser 
        115                 120                 125             


Lys Val Arg Asn Leu Lys Arg Ala Met Ala Thr Gly Ser Gly Ser Asn 
    130                 135                 140                 


Leu Arg Leu Arg Lys Ser Glu Met Pro Ala Asp Pro Tyr His Val Thr 
145                 150                 155                 160 


Ile Cys Glu Ile Trp Gly Glu Glu Ser Ser Ser 
                165                 170     


<210>  3960
<211>  694
<212>  DNA
<213>  Homosapiens

<400>  3960
gacatcacca agggcctggc accaggtgcc cagtcttcca gttgcgaggg caagcaaacc     60

cgtcatgagc aactcccttc cccatctctg ctcaccatgt ggacgctgaa atcgtccctg    120

gtcctgcttc tgtgcctcac ctgcagctat gcctttatgt tctcttctct gagacagaaa    180

actagcgaac cccaggggaa ggtgccgtgt ggagagcact ttcggattcg gcagaaccta    240

ccagagcaca cccaaggctg gcttgggagc aaatggctct ggcttttgtt tgctgttgtg    300

ccgtttgtga tactgcagtg tcaaagagac agtgagaaga ataaggagca gagtcctcct    360

ggccttcgag gcttcccatt tcgcactcca ctaaagaaaa atcaaaatgc ttctctttac    420

aaagactgtg tattcaatac cttaaacgaa cttgaagtgg agcttttgaa atttgtgtcc    480

gaagtgcaga atcttaaagg tgccatggca acaggcagtg gcagtaacct caagcttcga    540

aggtcagaga tgcctgcaga tccataccat gtcacaatct gtaaaatatg gggagaagaa    600

agctctagct gaatggattt gtgtgtcagg agagaaaaaa gttgagtgtt gacaaactgt    660

atgcaaacta ataaaactat tctgaagaaa agaa                                694


<210>  3961
<211>  171
<212>  PRT
<213>  Homosapiens

<400>  3961

Met Trp Thr Leu Lys Ser Ser Leu Val Leu Leu Leu Cys Leu Thr Cys 
1               5                   10                  15      


Ser Tyr Ala Phe Met Phe Ser Ser Leu Arg Gln Lys Thr Ser Glu Pro 
            20                  25                  30          


Gln Gly Lys Val Pro Cys Gly Glu His Phe Arg Ile Arg Gln Asn Leu 
        35                  40                  45              


Pro Glu His Thr Gln Gly Trp Leu Gly Ser Lys Trp Leu Trp Leu Leu 
    50                  55                  60                  


Phe Ala Val Val Pro Phe Val Ile Leu Gln Cys Gln Arg Asp Ser Glu 
65                  70                  75                  80  


Lys Asn Lys Glu Gln Ser Pro Pro Gly Leu Arg Gly Phe Pro Phe Arg 
                85                  90                  95      


Thr Pro Leu Lys Lys Asn Gln Asn Ala Ser Leu Tyr Lys Asp Cys Val 
            100                 105                 110         


Phe Asn Thr Leu Asn Glu Leu Glu Val Glu Leu Leu Lys Phe Val Ser 
        115                 120                 125             


Glu Val Gln Asn Leu Lys Gly Ala Met Ala Thr Gly Ser Gly Ser Asn 
    130                 135                 140                 


Leu Lys Leu Arg Arg Ser Glu Met Pro Ala Asp Pro Tyr His Val Thr 
145                 150                 155                 160 


Ile Cys Lys Ile Trp Gly Glu Glu Ser Ser Ser 
                165                 170     


<210>  3962
<211>  7292
<212>  DNA
<213>  Homosapiens

<400>  3962
aacactgata tttgcattta atggggaaca aaagatgaag aaggaaaagg aatatattca     60

ctaaggattc tatctgctta ctgctacaga cctatgtgtt aaggaattct tctcctcctc    120

cttgcgtaga agttgatcag cactgtggtc agactgcatt tatcttgtca ttgccagaag    180

aaatcttgga cagaatgtaa cagtacgtct ctctctgatt gcgatggaag gtgataaact    240

gatactcctt tattaaagtt acatcgcact caccacagaa aaccattctt taaagtgaat    300

agaaaccaag cccttgtgaa cacttctatt gaacatgact catggagaag agcttggctc    360

tgatgtgcac caggattcta ttgttttaac ttacctagaa ggattactaa tgcatcaggc    420

agcaggggga tcaggtactg ccgttgacaa aaagtctgct gggcataatg aagaggatca    480

gaactttaac atttctggca gtgcatttcc cacctgtcaa agtaatggtc cagttctcaa    540

tacacataca tatcaggggt ctggcatgct gcacctcaaa aaagccagac tgttgcagtc    600

ttctgaggac tggaatgcag caaagcggaa gaggctgtct gattctatca tgaatttaaa    660

cgtaaagaag gaagctttgc tagctggcat ggttgacagt gtgcctaaag gcaaacagga    720

tagcacatta ctggcctctt tgcttcagtc attcagctct aggctgcaga ctgttgctct    780

gtcacaacaa atcaggcaga gcctcaagga gcaaggatat gccctcagtc atgattcttt    840

aaaagtggag aaggatttaa ggtgctatgg tgttgcatca agtcacttaa aaactttgtt    900

gaagaaaagt aaagttaaag atcaaaagcc tgatacgaat cttcctgatg tgactaaaaa    960

cctcatcaga gataggtttg cagagtctcc tcatcatgtt ggacaaagtg gaacaaaggt   1020

catgagtgaa ccgttgtcat gtgctgcaag attacaggct gttgcaagca tggtggaaaa   1080

aagggctagt cctgccacct cacctaaacc tagtgttgct tgtagccagt tagcattact   1140

tctgtcaagc gaagcccatt tgcagcagta ttctcgagaa cacgctttaa aaacgcaaaa   1200

tgcaaatcaa gcagcaagtg aaagacttgc tgctatggcc agattgcaag aaaatggcca   1260

gaaggatgtt ggcagttacc agctcccaaa aggaatgtca agccatctta atggtcaggc   1320

aagaacatca tcaagcaaac tgatggctag caaaagtagt gctacagtgt ttcaaaatcc   1380

aatgggtatc attccttctt cccctaaaaa tgcaggttat aagaactcac tggaaagaaa   1440

caatataaaa caagctgcta acaatagttt gcttttacat cttcttaaaa gccagactat   1500

acctaagcca atgaatggac acagtcacag tgagagagga agcatttttg aggaaagtag   1560

tacacctaca actattgatg aatattcaga taacaatcct agttttacag atgacagcag   1620

tggtgatgaa agttcttatt ccaactgtgt tcccatagac ttgtcttgca aacaccgaac   1680

tgaaaaatca gaatctgacc aacctgtttc cctggataac ttcactcaat ccttgctaaa   1740

cacttgggat ccaaaagtcc cagatgtaga tatcaaagaa gatcaagata cctcaaagaa   1800

ttctaagcta aactcacacc agaaagtaac acttcttcaa ttgctacttg gccataagaa   1860

tgaagaaaat gtagaaaaaa acaccagccc tcagggagta cacaatgatg tgagcaagtt   1920

caatacacaa aattatgcaa ggacttctgt gatagaaagc cccagtacaa atcggactac   1980

tccagtgagc actccacctt tacttacatc aagcaaagca gggtctccca tcaatctctc   2040

tcaacactct ctggtcatca aatggaattc cccaccatat gtctgcagta ctcagtctga   2100

aaagctaaca aatactgcat ctaaccactc aatggacctt acaaaaagca aagacccacc   2160

aggagagaaa ccagcccaaa atgaaggtgc acagaactct gcaacgttta gtgccagtaa   2220

gctgttacaa aatttagcac aatgtggaat gcagtcatcc atgtcagtgg aagagcagag   2280

acccagcaaa cagctgttaa ctggaaacac agataaaccg ataggtatga ttgatagatt   2340

aaatagccct ttgctctcaa ataaaacaaa tgcagttgaa gaaaataaag catttagtag   2400

tcaaccaaca ggtcctgaac cagggctttc tggttctgaa atagaaaatc tgcttgaaag   2460

acgtactgtc ctccagttgc tcctggggaa ccccaacaaa gggaagagtg aaaaaaaaga   2520

gaaaactccc ttaagagatg aaagtactca ggaacactca gagagagctt taagtgaaca   2580

aatactgatg gtgaaaataa aatctgagcc ttgtgatgac ttacaaattc ctaacacaaa   2640

tgtgcacttg agccatgatg ctaagagtgc cccattcttg ggtatggctc ctgctgtgca   2700

gagaagcgca cctgccttac cagtgtccga agactttaaa tcggagcctg tttcacctca   2760

ggatttttct ttctccaaga atggtctgct aagtcgattg ctaagacaaa atcaagatag   2820

ttacctggca gatgattcag acaggagtca cagaaataat gaaatggcac ttctagaatc   2880

aaagaatctt tgcatggtcc ctaagaaaag gaagctttat actgagccat tagaaaatcc   2940

atttaaaaag atgaaaaaca acattgttga tgctgcaaac aatcacagtg ccccagaagt   3000

actgtatggg tccttgctta accaggaaga gctgaaattt agcagaaatg atcttgaatt   3060

taaatatcct gctggtcatg gctcagccag cgaaagtgaa cacaggagtt gggccagaga   3120

gagcaaaagc tttaatgttc tgaaacagct gcttctctca gaaaactgtg tgcgagattt   3180

gtccccgcac agaagtaact ctgtggctga cagtaaaaag aaaggacaca aaaataatgt   3240

gaccaacagc aaacctgaat ttagcatttc ttctttaaat ggactgatgt acagttccac   3300

tcagcccagc agttgcatgg ataacaggac attttcatac ccaggtgtag taaaaactcc   3360

tgtgagtcct actttccctg agcacttggg ctgtgcaggg tctagaccag aatctgggct   3420

tttgaatggg tgttccatgc ccagtgagaa aggacccatt aagtgggtta tcactgatgc   3480

ggagaagaat gagtatgaaa aagactctcc aagattgacc aaaaccaacc caatactata   3540

ttacatgctt caaaaaggag gcaattctgt taccagtcga gaaacacaag acaaggacat   3600

ttggagggag gcttcatctg ctgaaagtgt ctcacaggtc acagccaaag aagagttact   3660

tcctactgca gaaacgaaag cttctttctt taatttaaga agcccttaca atagccatat   3720

gggaaataat gcttctcgcc cacacagcgc aaatggagaa gtttatggac ttctgggaag   3780

cgtgctaacg ataaagaaag aatcagaata aaatgtacct gccatccagt tttggatctt   3840

tttaaaacta atgagtatga acttgagatc tgtataaata agagcatgat ttgaaaaaaa   3900

gcatggtata attgaaactt ttttcatttt gaaaagtatt ggttactggt gatgttgaaa   3960

tatgcatact aatttttgct taacattaga tgtcatgagg aaactactga actagcaatt   4020

ggttgtttaa cacttctgta tgcatcagat aacaactgtg agtagcctat gaatgaaatt   4080

cttttataaa tattaggcat aaattaaaat gtaaaactcc attcatagtg gattaatgca   4140

ttttgctgcc tttattaggg tactttattt tgcttttcag aagtcagcct acataacaca   4200

tttttaaagt ctaaactgtt aaacaactct ttaaaggata attatccaat aaaaaaaaac   4260

ctagtgctga ttcacagctt attatccaat tcaaaaataa attagaaaaa tatatgctta   4320

catttttcac ttttgctaaa aagaaaaaaa aaaggtgttt atttttaact cttggaagag   4380

gttttgtggt tcccaatgtg tctgtcccac cctgatcctt ttcaatatat atttctttaa   4440

accttgtgct acttagtaaa aattgattac aattgaggga agtttgatag atcctttaaa   4500

aaaaaggcag atttccattt tttgtatttt aactacttta ctaaattaat actcctcctt   4560

ttacagaatt agaaaagtta acatttatct ttaggtggtt tcctgaaaag ttgaatattt   4620

aagaaattgt ttttaacaga agcaaaatgg cttttctttg gacagttttc accatctctt   4680

gtaaaagtta attctcacca ttcctgtggt acctgcgagt gttatgacca ggattcctta   4740

aacctgaact cagaccactt gcattagaac catctggagc acttgtttta aaatgcagat   4800

tcataggcag catctcagat ctacagaaca agaatctctg ctaagtggac ctggaatctt   4860

ccatctgcat cttaacatgc tctctaggtg tttcttgtgt ttgagaacca tgacttatga   4920

ctttcctcag aacatgagac tgtaaaacaa aaacaaaaaa ctatgtgatg cctctatttt   4980

ccccaataca gtcacacatc agctcaaaat ttgcaatatt gtagttcata tattaccgtt   5040

atgtctttgg aaatcgggtt cagaacactt tttatgacaa aaattgggtg gaggggataa   5100

ctttcatatc tggctcaaca tctcaggaaa atctgtgatt atttgtgtgt tctaatgagt   5160

aacatctact tagttagcct tagggatgga aaaacagggc cacttaccaa actcaggtga   5220

ttccaggatg gtttggaaac ttctcctgaa tgcatcctta acctttatta aaaccattgt   5280

cctaagaaca atgccaacaa agcttacaac atttagttta aacccaagaa gggcactaaa   5340

ctcagattga ctaaataaaa agtacaaagg gcacatatac gtgacagaat tgtacacaat   5400

cactccattg gatcttttac tttaaagtag tgatgaaaag tacatgttga tactgtctta   5460

gaagaaatta atatattagt gaagccacat ggggtttcag ttgcgaaaca ggtctgtttt   5520

tatgttcagt ttgtacaatc cacaattcat tcaccagata ttttgttctt aattgtgaac   5580

caggttagca aatgacctat caaaaattat tctataatca ctactagtta ggatattgat   5640

ttaaaattgt tctacttgaa gtggtttcta agatttttat attaaaaata ggtgtgattt   5700

cctaatatga tctaaaaccc taaatggtta tttttcctca gaatgatttg taaatagcta   5760

ctggaaatat tatacagtaa taggagtggg tattatgcaa catcatggag aagtgaaggc   5820

ataggcttat tctgacataa aattccactg gccagttgaa tatattctat tccatgtcca   5880

tactatgaca atcttattgt caacactata taaataagct tttaaacaag tcatttttct   5940

tgatcgttgt ggaaggtttg gagccttaga ggtatgtcag aaaaaatatg ttggtattct   6000

cccttgggta gggggaaatg acctttttac aagagagtga aatttaggtc agggaaaaga   6060

ccaagggcca gcattgctac ttttgtgtgt gtgtgtgtgg gttttgtttt gtttttttgg   6120

ttggctggtt gttttcgttg ttgttaacaa aggaatgaga atatgtaata cttaaataaa   6180

catgaccacg aagaatgctg ttctgattta ctagagaatg ttcccaattt gaatttaggg   6240

tgattttaaa gaacagtgag aaagggcata catccacaga ttcactttgt ttatgcatat   6300

gtagatacaa ggatgcacat atacacattt tcaaggacta ttttagatat ctagacaatt   6360

tcttctaata aagtcatttg tgaaagggta ctacagctta ttgacatcag taaggtagca   6420

ttcattacct gtttattctc tgctgcatct tacagaagag taaactggtg agagtatata   6480

ttttatatat atatatatat atatatatat aatatgtata tatatatata ttgacttgtt   6540

acatgaagat gttaaaatcg gtttttaaag gtgatgtaaa tagtgatttc cttaatgaaa   6600

aatacatatt ttgtattgtt ctaatgcaac agaaaagcct tttaatctct ttggttcctg   6660

tatattccat gtataagtgt aaatataatc agacaggttt aaaagttgtg catgtatgta   6720

tacagttgca agtctggaca aatgtataga ataaaccttt tatttaagtt gtgattacct   6780

gctgcatgaa aagtgcatgg gggaccctgt gcatctgtgc atttggcaaa atgtcttaac   6840

aaatcagatc agatgttcat cctaacatga cagtattcca tttctggaca tgacgtctgt   6900

ggtttaagct ttgtgaaaga atgtgctttg attcgaaggg tcttaaagaa tttttttaat   6960

cgtcaaccac ttttaaacat aaagaattca cacaactact ttcatgaatt ttttaatccc   7020

attgcaaaca ttattccaag agtatcccag tattagcaat actggaatat aggcacatta   7080

ccattcatag taagaattct ggtgtttaca caaccaaatt tgatgcgatc tgctcagtaa   7140

tataatttgc catttttatt agaaatttaa tttcttcatg tgatgtcatg aaactgtaca   7200

tactgcagtg tgaatttttt tgttttgttt tttaatcttt tagtgtttac ttcctgcagt   7260

gaatttgaat aaatgagaaa aaatgcattg tc                                 7292


<210>  3963
<211>  1158
<212>  PRT
<213>  Homosapiens

<400>  3963

Met Thr His Gly Glu Glu Leu Gly Ser Asp Val His Gln Asp Ser Ile 
1               5                   10                  15      


Val Leu Thr Tyr Leu Glu Gly Leu Leu Met His Gln Ala Ala Gly Gly 
            20                  25                  30          


Ser Gly Thr Ala Val Asp Lys Lys Ser Ala Gly His Asn Glu Glu Asp 
        35                  40                  45              


Gln Asn Phe Asn Ile Ser Gly Ser Ala Phe Pro Thr Cys Gln Ser Asn 
    50                  55                  60                  


Gly Pro Val Leu Asn Thr His Thr Tyr Gln Gly Ser Gly Met Leu His 
65                  70                  75                  80  


Leu Lys Lys Ala Arg Leu Leu Gln Ser Ser Glu Asp Trp Asn Ala Ala 
                85                  90                  95      


Lys Arg Lys Arg Leu Ser Asp Ser Ile Met Asn Leu Asn Val Lys Lys 
            100                 105                 110         


Glu Ala Leu Leu Ala Gly Met Val Asp Ser Val Pro Lys Gly Lys Gln 
        115                 120                 125             


Asp Ser Thr Leu Leu Ala Ser Leu Leu Gln Ser Phe Ser Ser Arg Leu 
    130                 135                 140                 


Gln Thr Val Ala Leu Ser Gln Gln Ile Arg Gln Ser Leu Lys Glu Gln 
145                 150                 155                 160 


Gly Tyr Ala Leu Ser His Asp Ser Leu Lys Val Glu Lys Asp Leu Arg 
                165                 170                 175     


Cys Tyr Gly Val Ala Ser Ser His Leu Lys Thr Leu Leu Lys Lys Ser 
            180                 185                 190         


Lys Val Lys Asp Gln Lys Pro Asp Thr Asn Leu Pro Asp Val Thr Lys 
        195                 200                 205             


Asn Leu Ile Arg Asp Arg Phe Ala Glu Ser Pro His His Val Gly Gln 
    210                 215                 220                 


Ser Gly Thr Lys Val Met Ser Glu Pro Leu Ser Cys Ala Ala Arg Leu 
225                 230                 235                 240 


Gln Ala Val Ala Ser Met Val Glu Lys Arg Ala Ser Pro Ala Thr Ser 
                245                 250                 255     


Pro Lys Pro Ser Val Ala Cys Ser Gln Leu Ala Leu Leu Leu Ser Ser 
            260                 265                 270         


Glu Ala His Leu Gln Gln Tyr Ser Arg Glu His Ala Leu Lys Thr Gln 
        275                 280                 285             


Asn Ala Asn Gln Ala Ala Ser Glu Arg Leu Ala Ala Met Ala Arg Leu 
    290                 295                 300                 


Gln Glu Asn Gly Gln Lys Asp Val Gly Ser Tyr Gln Leu Pro Lys Gly 
305                 310                 315                 320 


Met Ser Ser His Leu Asn Gly Gln Ala Arg Thr Ser Ser Ser Lys Leu 
                325                 330                 335     


Met Ala Ser Lys Ser Ser Ala Thr Val Phe Gln Asn Pro Met Gly Ile 
            340                 345                 350         


Ile Pro Ser Ser Pro Lys Asn Ala Gly Tyr Lys Asn Ser Leu Glu Arg 
        355                 360                 365             


Asn Asn Ile Lys Gln Ala Ala Asn Asn Ser Leu Leu Leu His Leu Leu 
    370                 375                 380                 


Lys Ser Gln Thr Ile Pro Lys Pro Met Asn Gly His Ser His Ser Glu 
385                 390                 395                 400 


Arg Gly Ser Ile Phe Glu Glu Ser Ser Thr Pro Thr Thr Ile Asp Glu 
                405                 410                 415     


Tyr Ser Asp Asn Asn Pro Ser Phe Thr Asp Asp Ser Ser Gly Asp Glu 
            420                 425                 430         


Ser Ser Tyr Ser Asn Cys Val Pro Ile Asp Leu Ser Cys Lys His Arg 
        435                 440                 445             


Thr Glu Lys Ser Glu Ser Asp Gln Pro Val Ser Leu Asp Asn Phe Thr 
    450                 455                 460                 


Gln Ser Leu Leu Asn Thr Trp Asp Pro Lys Val Pro Asp Val Asp Ile 
465                 470                 475                 480 


Lys Glu Asp Gln Asp Thr Ser Lys Asn Ser Lys Leu Asn Ser His Gln 
                485                 490                 495     


Lys Val Thr Leu Leu Gln Leu Leu Leu Gly His Lys Asn Glu Glu Asn 
            500                 505                 510         


Val Glu Lys Asn Thr Ser Pro Gln Gly Val His Asn Asp Val Ser Lys 
        515                 520                 525             


Phe Asn Thr Gln Asn Tyr Ala Arg Thr Ser Val Ile Glu Ser Pro Ser 
    530                 535                 540                 


Thr Asn Arg Thr Thr Pro Val Ser Thr Pro Pro Leu Leu Thr Ser Ser 
545                 550                 555                 560 


Lys Ala Gly Ser Pro Ile Asn Leu Ser Gln His Ser Leu Val Ile Lys 
                565                 570                 575     


Trp Asn Ser Pro Pro Tyr Val Cys Ser Thr Gln Ser Glu Lys Leu Thr 
            580                 585                 590         


Asn Thr Ala Ser Asn His Ser Met Asp Leu Thr Lys Ser Lys Asp Pro 
        595                 600                 605             


Pro Gly Glu Lys Pro Ala Gln Asn Glu Gly Ala Gln Asn Ser Ala Thr 
    610                 615                 620                 


Phe Ser Ala Ser Lys Leu Leu Gln Asn Leu Ala Gln Cys Gly Met Gln 
625                 630                 635                 640 


Ser Ser Met Ser Val Glu Glu Gln Arg Pro Ser Lys Gln Leu Leu Thr 
                645                 650                 655     


Gly Asn Thr Asp Lys Pro Ile Gly Met Ile Asp Arg Leu Asn Ser Pro 
            660                 665                 670         


Leu Leu Ser Asn Lys Thr Asn Ala Val Glu Glu Asn Lys Ala Phe Ser 
        675                 680                 685             


Ser Gln Pro Thr Gly Pro Glu Pro Gly Leu Ser Gly Ser Glu Ile Glu 
    690                 695                 700                 


Asn Leu Leu Glu Arg Arg Thr Val Leu Gln Leu Leu Leu Gly Asn Pro 
705                 710                 715                 720 


Asn Lys Gly Lys Ser Glu Lys Lys Glu Lys Thr Pro Leu Arg Asp Glu 
                725                 730                 735     


Ser Thr Gln Glu His Ser Glu Arg Ala Leu Ser Glu Gln Ile Leu Met 
            740                 745                 750         


Val Lys Ile Lys Ser Glu Pro Cys Asp Asp Leu Gln Ile Pro Asn Thr 
        755                 760                 765             


Asn Val His Leu Ser His Asp Ala Lys Ser Ala Pro Phe Leu Gly Met 
    770                 775                 780                 


Ala Pro Ala Val Gln Arg Ser Ala Pro Ala Leu Pro Val Ser Glu Asp 
785                 790                 795                 800 


Phe Lys Ser Glu Pro Val Ser Pro Gln Asp Phe Ser Phe Ser Lys Asn 
                805                 810                 815     


Gly Leu Leu Ser Arg Leu Leu Arg Gln Asn Gln Asp Ser Tyr Leu Ala 
            820                 825                 830         


Asp Asp Ser Asp Arg Ser His Arg Asn Asn Glu Met Ala Leu Leu Glu 
        835                 840                 845             


Ser Lys Asn Leu Cys Met Val Pro Lys Lys Arg Lys Leu Tyr Thr Glu 
    850                 855                 860                 


Pro Leu Glu Asn Pro Phe Lys Lys Met Lys Asn Asn Ile Val Asp Ala 
865                 870                 875                 880 


Ala Asn Asn His Ser Ala Pro Glu Val Leu Tyr Gly Ser Leu Leu Asn 
                885                 890                 895     


Gln Glu Glu Leu Lys Phe Ser Arg Asn Asp Leu Glu Phe Lys Tyr Pro 
            900                 905                 910         


Ala Gly His Gly Ser Ala Ser Glu Ser Glu His Arg Ser Trp Ala Arg 
        915                 920                 925             


Glu Ser Lys Ser Phe Asn Val Leu Lys Gln Leu Leu Leu Ser Glu Asn 
    930                 935                 940                 


Cys Val Arg Asp Leu Ser Pro His Arg Ser Asn Ser Val Ala Asp Ser 
945                 950                 955                 960 


Lys Lys Lys Gly His Lys Asn Asn Val Thr Asn Ser Lys Pro Glu Phe 
                965                 970                 975     


Ser Ile Ser Ser Leu Asn Gly Leu Met Tyr Ser Ser Thr Gln Pro Ser 
            980                 985                 990         


Ser Cys Met Asp Asn Arg Thr Phe  Ser Tyr Pro Gly Val  Val Lys Thr 
        995                 1000                 1005             


Pro Val  Ser Pro Thr Phe Pro  Glu His Leu Gly Cys  Ala Gly Ser 
    1010                 1015                 1020             


Arg Pro  Glu Ser Gly Leu Leu  Asn Gly Cys Ser Met  Pro Ser Glu 
    1025                 1030                 1035             


Lys Gly  Pro Ile Lys Trp Val  Ile Thr Asp Ala Glu  Lys Asn Glu 
    1040                 1045                 1050             


Tyr Glu  Lys Asp Ser Pro Arg  Leu Thr Lys Thr Asn  Pro Ile Leu 
    1055                 1060                 1065             


Tyr Tyr  Met Leu Gln Lys Gly  Gly Asn Ser Val Thr  Ser Arg Glu 
    1070                 1075                 1080             


Thr Gln  Asp Lys Asp Ile Trp  Arg Glu Ala Ser Ser  Ala Glu Ser 
    1085                 1090                 1095             


Val Ser  Gln Val Thr Ala Lys  Glu Glu Leu Leu Pro  Thr Ala Glu 
    1100                 1105                 1110             


Thr Lys  Ala Ser Phe Phe Asn  Leu Arg Ser Pro Tyr  Asn Ser His 
    1115                 1120                 1125             


Met Gly  Asn Asn Ala Ser Arg  Pro His Ser Ala Asn  Gly Glu Val 
    1130                 1135                 1140             


Tyr Gly  Leu Leu Gly Ser Val  Leu Thr Ile Lys Lys  Glu Ser Glu 
    1145                 1150                 1155             


<210>  3964
<211>  1114
<212>  DNA
<213>  Homosapiens

<400>  3964
acactgcgct gcccagaggc cccgctgact cctgccagcc tccaggtccc cgtggtacca     60

aagctgaaca tggacgtgac catccagcac ccctggttca agcgcaccct ggggcccttc    120

taccccagcc ggctgttcga ccagtttttc ggcgagggcc tttttgagta tgacctgctg    180

cccttcctgt cgtccaccat cagcccctac taccgccagt ccctcttccg caccgtgctg    240

gactccggca tctctgaggt tcgatccgac cgggacaagt tcgtcatctt cctcgatgtg    300

aagcacttct ccccggagga cctcaccgtg aaggtgcagg acgactttgt ggagatccac    360

ggaaagcaca acgagcgcca ggacgaccac ggctacattt cccgtgagtt ccaccgccgc    420

taccgcctgc cgtccaacgt ggaccagtcg gccctctctt gctccctgtc tgccgatggc    480

atgctgacct tctgtggccc caagatccag actggcctgg atgccaccca cgccgagcga    540

gccatccccg tgtcgcggga ggagaagccc acctcggctc cctcgtccta agcaggcatt    600

gcctcggctg gctcccctgc agccctggcc catcatgggg ggagcaccct gagggcgggg    660

tgtctgtctt cctttgcttc ccttttttcc tttccacctt ctcacatgga atgagggttt    720

gagagagcag ccaggagagc ttagggtctc agggtgtccc agaccccgac accggccagt    780

ggcggaagtg accgcacctc acactccttt agatagcagc ctggctcccc tggggtgcag    840

gcgcctcaac tctgctgagg gtccagaagg agggggtgac ctccggccag gtgcctcctg    900

acacacctgc agcctccctc cgcggcgggc cctgcccaca cctcctgggg cgcgtgaggc    960

ccgtggggcc ggggcttctg tgcacctggg ctctcgcggc ctcttctctc agaccgtctt   1020

cctccaaccc ctctatgtag tgccgctctt ggggacatgg gtcgcccatg agagcgcagc   1080

ccgcggcaat caataaacag caggtgatac aagc                               1114


<210>  3965
<211>  173
<212>  PRT
<213>  Homosapiens

<400>  3965

Met Asp Val Thr Ile Gln His Pro Trp Phe Lys Arg Thr Leu Gly Pro 
1               5                   10                  15      


Phe Tyr Pro Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu Gly Leu Phe 
            20                  25                  30          


Glu Tyr Asp Leu Leu Pro Phe Leu Ser Ser Thr Ile Ser Pro Tyr Tyr 
        35                  40                  45              


Arg Gln Ser Leu Phe Arg Thr Val Leu Asp Ser Gly Ile Ser Glu Val 
    50                  55                  60                  


Arg Ser Asp Arg Asp Lys Phe Val Ile Phe Leu Asp Val Lys His Phe 
65                  70                  75                  80  


Ser Pro Glu Asp Leu Thr Val Lys Val Gln Asp Asp Phe Val Glu Ile 
                85                  90                  95      


His Gly Lys His Asn Glu Arg Gln Asp Asp His Gly Tyr Ile Ser Arg 
            100                 105                 110         


Glu Phe His Arg Arg Tyr Arg Leu Pro Ser Asn Val Asp Gln Ser Ala 
        115                 120                 125             


Leu Ser Cys Ser Leu Ser Ala Asp Gly Met Leu Thr Phe Cys Gly Pro 
    130                 135                 140                 


Lys Ile Gln Thr Gly Leu Asp Ala Thr His Ala Glu Arg Ala Ile Pro 
145                 150                 155                 160 


Val Ser Arg Glu Glu Lys Pro Thr Ser Ala Pro Ser Ser 
                165                 170             


<210>  3966
<211>  2815
<212>  DNA
<213>  Homosapiens

<400>  3966
atttccagtg gatgcaatag tgccgaccat gtgcacatgg ggtcaggatc tcaggcccac     60

cagctggact gcagcgagta cccatggtct cagggaaaag gtcccctgct gcaggctgtg    120

ggggacctcg gctctcacag tggctatgcc tgagaaagcc cctccagact tgccaacctg    180

gcccgcgtgt cctgtccgga gggcagggtg gggctggtgc tggttacaga tgatcctcaa    240

gggcacagca cgcaagccac caggcgcccc tcctgcagct gggtcagaga gaggcacagg    300

gagcctggct ccctccaggt cagtctccac cagggccacc ccggtgacct gcaggagagg    360

aaggcagacg aggagtggcc ctgcccctga gggcgcatcg tgcaggtggc acaagggggt    420

catctgcatc ctggtcaagg gggagcccac ctgcctcctc caggtcggga acactccctg    480

gaggccatgg tgtggagcgt ccacccgggc ttcgtcctcc agctcagctg ctgggccctg    540

ggaagggaca ggcccagcac ccgttcagcc gggctgagcc gcaggcagag cgccttgcct    600

gggagagaca aacccaccgc tgaggacaca ccctcaaggt tcacccttcc ccacttctgt    660

gttgccctta gctctaaggt gctaattcca tctctagttt caacaggctg attgctctta    720

agggaaaatg gggttgcaca atccgactgt ggtggccggg gctcttggtc tccccccagt    780

aagaggatgg actttccagc cctgctgatg gtcagcgggg accacgtgga ggctttggca    840

gatgaaatgg ggcacatgac atagccctgc cccagtggaa gcctcagagc catggctggg    900

ctccgccagg cttgctccag cggccatgag gaccatgccc cacaggcagg ggctgcacct    960

ccaccctggt tccagaagga agaggcacag ccgacatgcc gctcgagcag gaaaccctgg   1020

ggaaggtggg acatgagatc ctgtgtctga tactacagtg taaccggcta gaaactgact   1080

caaaggggca tttttacagc agaaagaggc gaagcacacg tgcatctgcc atcctgtgat   1140

tgtcaggccc cgtttaggag tggacagctc catggttgtg tttgagcccc acaccggccc   1200

tggggggtta tactgccctg gaggacagct gacctcagtt ctccaagctt ccattccccc   1260

ttgtatgggc acagcacccc aaccttcttt tggcagctcc cacgcccccc agtgctggtg   1320

ggctctaggg ctctggtccc tgatgctcag aggcacagag acagcattcc tcaggggccc   1380

tgatcctctg gcccggttca gactgtggtg gggcctcggg acctttccag aaccttggaa   1440

gtgggtagca ccctttgctg ggacagacat gcctggagct ccgggcattg ggccactgct   1500

gggataagcc cacgacagaa tgaagccggg caggcagaaa gagctgcggg ctccctggcc   1560

actcctgttt ccgtaaaggg cctggtgtct catttcctac ttaccttgga ctttaagggc   1620

ctcctgcagc ctttgtcaca cactcttctt atttttttgt ccattacaac cttttacagc   1680

ggcacaagcc attgttctca gggccaacgc gtgagtcctg tggtgagttt cctattagtg   1740

tggctcgaga aggtaccccg tgctgacgaa gcctggagag gcagggccac actgcagagc   1800

ctcaggccaa gggtggcggt gctggggtct catgagccca gggttcactg cccaccaggc   1860

ggcattagcc tgcggctttg gcgcccagaa gtccgacagg cagcaaagtc tcctgctcct   1920

ggctgctggc caggagagcc cagctgggcc tcacctgatc gagaggaaac gcctgtgtcc   1980

tctaatcagc atctcactga cagagtcacc cctggtacag caagtgggct ttcaaggaca   2040

tcaggtggct gcattcaggc tggtaacaac accgccctca gctctcacag tctgaggaag   2100

ccccctgaaa agtcactgga gtggggctgc aggaacccca caaaggcctt tcctgctcct   2160

gaataattcc caagcaccta ggactccccg ggcctggctt ctccgccagc ccaacctccg   2220

gacctgaaga ccaagcagtg cccaagtgtg aggtccctgg agaaggagga ggaagagtgg   2280

aaggaggtgg agggtaacgc atccagagga agacgctgag ggtcaggctg gccctgggtc   2340

tgacctgtcc ttgggatcaa ctgcttcatt aaaaaacatc cgcctaaact gtggagacag   2400

aggaaggatc agtgcttgcc aagggctggg ggaggaggaa caggcagagc gcagagggtt   2460

tcagggcagt gccgctctgc gtgacgccat cacggagggt ccaggtcatc acacgtctct   2520

ccaaacccct agaatgccca acactcactc tgaagccttc tgtcaatgtg ggatcatctg   2580

tcgtaaagtc tgcaccgctg tggtgggggc gtggatagtg ggggaggctg tgcgtgtgtg   2640

ggggcaggga gtgtatggga aatctctgta ccttccgctc aatttggctg cgaacctaaa   2700

ctgctctaaa aaaagtctat ttttaaaaag catatgcccg aaaagtcctt gaaaatgcat   2760

ctttccctaa atattcaaat ttatgttcat taataaaata gcacatattt attct        2815


<210>  3967
<211>  182
<212>  PRT
<213>  Homosapiens

<400>  3967

Met Cys Thr Trp Gly Gln Asp Leu Arg Pro Thr Ser Trp Thr Ala Ala 
1               5                   10                  15      


Ser Thr His Gly Leu Arg Glu Lys Val Pro Cys Cys Arg Leu Trp Gly 
            20                  25                  30          


Thr Ser Ala Leu Thr Val Ala Met Pro Glu Lys Ala Pro Pro Asp Leu 
        35                  40                  45              


Pro Thr Trp Pro Ala Cys Pro Val Arg Arg Ala Gly Trp Gly Trp Cys 
    50                  55                  60                  


Trp Leu Gln Met Ile Leu Lys Gly Thr Ala Arg Lys Pro Pro Gly Ala 
65                  70                  75                  80  


Pro Pro Ala Ala Gly Ser Glu Arg Gly Thr Gly Ser Leu Ala Pro Ser 
                85                  90                  95      


Arg Ser Val Ser Thr Arg Ala Thr Pro Val Thr Cys Arg Arg Gly Arg 
            100                 105                 110         


Gln Thr Arg Ser Gly Pro Ala Pro Glu Gly Ala Ser Cys Arg Trp His 
        115                 120                 125             


Lys Gly Val Ile Cys Ile Leu Val Lys Gly Glu Pro Thr Cys Leu Leu 
    130                 135                 140                 


Gln Val Gly Asn Thr Pro Trp Arg Pro Trp Cys Gly Ala Ser Thr Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Ser Ser Ala Ala Gly Pro Trp Glu Gly Thr Gly Pro 
                165                 170                 175     


Ala Pro Val Gln Pro Gly 
            180         


<210>  3968
<211>  4723
<212>  DNA
<213>  Homosapiens

<400>  3968
atgcggcgcg gccccggagg cagcagcagc ggcggcggca gccggagcag taggcacccg     60

agcagcgcca gcggccgagc gggcggcttc ctggcctggg cgctccggtg gcggcggagg    120

tgcgcgcgga gccatggtta tcatgtcgga gttcagcgcg gaccccgcgg gccagggtca    180

gggccagcag aagcccctcc gggtgggttt ttacgacatc gagcggaccc tgggcaaagg    240

caacttcgcg gtggtgaagc tggcgcggca tcgagtcacc aaaacgcagg ttgcaataaa    300

aataattgat aaaacacgat tagattcaag caatttggag aaaatctatc gtgaggttca    360

gctgatgaag cttctgaacc atccacacat cataaagctt taccaggtta tggaaacaaa    420

ggacatgctt tacatcgtca ctgaatttgc taaaaatgga gaaatgtttg attatttgac    480

ttccaacggg cacctgagtg agaacgaggc gcggaagaag ttctggcaaa tcctgtcggc    540

cgtggagtac tgtcacgacc atcacatcgt ccaccgggac ctcaagaccg agaacctcct    600

gctggatggc aacatggaca tcaagctggc agattttgga tttgggaatt tctacaagtc    660

aggagagcct ctgtccacgt ggtgtgggag ccccccgtat gccgccccgg aagtctttga    720

ggggaaggag tatgaaggcc cccagctgga catctggagc ctgggcgtgg tgctgtacgt    780

cctggtctgc ggttctctcc ccttcgatgg gcctaacctg ccgacgctga gacagcgggt    840

gctggagggc cgcttccgca tccccttctt catgtctcaa gactgtgaga gcctgatccg    900

ccgcatgctg gtggtggacc ccgccaggcg catcaccatc gcccagatcc ggcagcaccg    960

gtggatgcgg gctgagccct gcttgccggg acccgcctgc cccgccttct ccgcacacag   1020

ctacacctcc aacctgggcg actacgatga gcaggcgctg ggtatcatgc agaccctggg   1080

cgtggaccgg cagaggacgg tggagtcact gcaaaacagc agctataacc actttgctgc   1140

catttattac ctcctccttg agcggctcaa ggagtatcgg aatgcccagt gcgcccgccc   1200

cgggcctgcc aggcagccgc ggcctcggag ctcggacctc agtggtttgg aggtgcctca   1260

ggaaggtctt tccaccgacc ctttccgacc tgccttgctg tgcccgcagc cgcagacctt   1320

ggtgcagtcc gtcctccagg ccgagatgga ctgtgagctc cagagctcgc tgcagtggcc   1380

cttgttcttc ccggtggatg ccagctgcag cggagtgttc cggccccggc ccgtgtcccc   1440

aagcagcctg ctggacacag ccatcagtga ggaggccagg caggggccgg gcctagagga   1500

ggagcaggac acgcaggagt ccctgcccag cagcacgggc cggaggcaca ccctggccga   1560

ggtctccacc cgcctctccc cactcaccgc gccatgtata gtcgtctccc cctccaccac   1620

ggcaagtcct gcagagggaa ccagctctga cagttgtctg accttctctg cgagcaaaag   1680

ccccgcgggg ctcagtggca ccccggccac tcaggggctg ctgggcgcct gctccccggt   1740

caggctggcc tcgcccttcc tggggtcgca gtccgccacc ccagtgctgc aggctcaggg   1800

gggcttggga ggagctgttc tgctccctgt cagcttccag gagggacggc gggcgtcgga   1860

cacctcactg actcaagggc tgaaggcctt tcggcagcag ctgaggaaga ccacgcggac   1920

caaagggttt ctgggactga acaaaatcaa ggggctggct cgccaggtgt gccaggtccc   1980

tgccagccgg gccagcaggg gcggcctgag ccccttccac gcccctgcac agagcccagg   2040

cctgcacggc ggcgcagccg gcagccggga gggctggagc ctgctggagg aggtgctaga   2100

gcagcagagg ctgctccagt tacagcacca cccggccgct gcacccggct gctcccaggc   2160

cccccagccg gcccctgccc cgtttgtgat cgccccctgt gatggccctg gggctgcccc   2220

gctccccagc accctcctca cgtcggggct cccgctgctg ccgcccccac tcctgcagac   2280

cggcgcgtcc ccggtggcct cagcggcgca gctcctggac acacacctgc acattggcac   2340

cggccccacc gccctccccg ctgtgccccc accacgcctg gccaggctgg ccccaggttg   2400

tgagcccctg gggctgctgc agggggactg tgagatggag gacctgatgc cctgctccct   2460

aggcacgttt gtcctggtgc agtgagggca gccctgcatc ctggcacgga cactgactct   2520

tacagcaata acttcagagg aggtgaagac atctggcctc aaagccaaga actttctaga   2580

agcgaaataa gcaatacgtt aggtgttttg gctttttagt ttatttttgt tttatttttt   2640

tcttgcactg agtgacctca actttgagta gggactggaa actttaggaa gaaagataat   2700

tgaggggcgt gtctgggggc gggggcagga ggggagcggg gtggagggaa cacgtgcagt   2760

gccgtggtgt ggggatctcg gcccctctct ctgggttcgt cgtggttgag atgattacct   2820

cggacgtcta cggaaacgag cgggcgcatt gttgtccgct tgtgtgtgtg tgtgtgtgtg   2880

tgtgtgtgcg cgtgcattga ttactatcca tttctttagt caacgctctc cacttcctga   2940

tttctgcttt aaggaaaact gtgaactttc tgcttcatgt atcagtttta aagcagccca   3000

ggcaaagatc atctacagat tctaggaatt ctctcccctg aaatcaaaac ctggaagact   3060

tttttttctt attttagttg agaagtttca taaactgctc aaggattagt tttccaggac   3120

tctgcggagg aacggcagga agaacctcag agagggcaga ggtgacttca aagtgctggg   3180

gactccgtcc tgagggtcac ttggccctga gcccctgcgt gcccttgcgg aagcccagaa   3240

gcttcttcct gctgcacctc ccgtttccgc tgctgctgac gtttatgcat ttcatgatgg   3300

ggtccaacaa gaacacctga cttgggtgaa gttgtgcaat attggaggct gactgtaggg   3360

ctgggcagct gggagacagg ctcatggctc atggctcatg gctcagggcg gtgcctgccc   3420

tgggccggga cccccctccc caccccccac ctaggctttt tgggttttgt tcaaggaagg   3480

taaagtgaga ggtttaggtc agtgttttta agtttttgtt ttttttttaa agcaaatcct   3540

gtatatgtat ctacatggga gacaggtaga cactacttat ttgttacatt ttgtactata   3600

cgtttgtgtt ccaggtttca gcttccctcg ctcctgttgt taagaagcgt ccctgtcagc   3660

acaggtgtgc attgaggaag gggccccagg gccttcgctc cctcagcact ggggtggagg   3720

cggcaggaag gggcggccct tacctggcag gtctgggcgc acctttagca ggtggactcc   3780

gtggggctcc accagccaga agcctctgga aggcaacgaa ggcaatgctg ctccctgagt   3840

ccagtccccg cccccaaacc cagcccaggt gccttcagct acttcggctt cttaaaccct   3900

gcagtgttaa acagaggcat tgagaaaggg gaaaggcggg tatttttaaa agccaaagat   3960

tgacccagtt acttgagggt agggaggcgg gcccagtgca ggaggctgca tccctggcct   4020

gctggtgccc accgggggct gtgcctgtgc cgggccgcag ggaagctggc tgcccccatt   4080

cctgctgctg ctgctgctgc tgctctgtgg ctgtttcaaa gactgggcga aaggctgtcc   4140

ggagggcaga ccaggtgcct tgccgcagag aaaacaccaa agtctcctgt tcgctcataa   4200

agaagttttt gggatgggag agaatccaga ccatcttggg gcagccaggc ccttgccttc   4260

atttttacag aggtagcaca actgattcca acacaaaacc ccttcccctt tttaaaatga   4320

tttctgttct aatgccatag atcaaaggcc tcagaaacca ttgtgtgttt cctctttgaa   4380

gcaatgacaa gcactttact ttcacggtgg tttttgtttt ttcttattgc tgtggaacct   4440

cttttggagg acgttaaagg cgtgttttac ttgttttttt aagagtgtgt gatgtgtgtt   4500

ttgtagattt cttgacagtg ctgtaataca gacggcaatg caatagccta tttaaagaca   4560

ctacgtgatc tgattgagat gtacatagtt ttttttttta ccataactga attattttat   4620

ctcttatgtt aacatgagaa atgtatgcca aatgattagt tgatgtatgt tttttaattt   4680

aatatttaaa taaaatattt ggaaggaaaa aaaaaaaaaa aaa                     4723


<210>  3969
<211>  783
<212>  PRT
<213>  Homosapiens

<400>  3969

Met Val Ile Met Ser Glu Phe Ser Ala Asp Pro Ala Gly Gln Gly Gln 
1               5                   10                  15      


Gly Gln Gln Lys Pro Leu Arg Val Gly Phe Tyr Asp Ile Glu Arg Thr 
            20                  25                  30          


Leu Gly Lys Gly Asn Phe Ala Val Val Lys Leu Ala Arg His Arg Val 
        35                  40                  45              


Thr Lys Thr Gln Val Ala Ile Lys Ile Ile Asp Lys Thr Arg Leu Asp 
    50                  55                  60                  


Ser Ser Asn Leu Glu Lys Ile Tyr Arg Glu Val Gln Leu Met Lys Leu 
65                  70                  75                  80  


Leu Asn His Pro His Ile Ile Lys Leu Tyr Gln Val Met Glu Thr Lys 
                85                  90                  95      


Asp Met Leu Tyr Ile Val Thr Glu Phe Ala Lys Asn Gly Glu Met Phe 
            100                 105                 110         


Asp Tyr Leu Thr Ser Asn Gly His Leu Ser Glu Asn Glu Ala Arg Lys 
        115                 120                 125             


Lys Phe Trp Gln Ile Leu Ser Ala Val Glu Tyr Cys His Asp His His 
    130                 135                 140                 


Ile Val His Arg Asp Leu Lys Thr Glu Asn Leu Leu Leu Asp Gly Asn 
145                 150                 155                 160 


Met Asp Ile Lys Leu Ala Asp Phe Gly Phe Gly Asn Phe Tyr Lys Ser 
                165                 170                 175     


Gly Glu Pro Leu Ser Thr Trp Cys Gly Ser Pro Pro Tyr Ala Ala Pro 
            180                 185                 190         


Glu Val Phe Glu Gly Lys Glu Tyr Glu Gly Pro Gln Leu Asp Ile Trp 
        195                 200                 205             


Ser Leu Gly Val Val Leu Tyr Val Leu Val Cys Gly Ser Leu Pro Phe 
    210                 215                 220                 


Asp Gly Pro Asn Leu Pro Thr Leu Arg Gln Arg Val Leu Glu Gly Arg 
225                 230                 235                 240 


Phe Arg Ile Pro Phe Phe Met Ser Gln Asp Cys Glu Ser Leu Ile Arg 
                245                 250                 255     


Arg Met Leu Val Val Asp Pro Ala Arg Arg Ile Thr Ile Ala Gln Ile 
            260                 265                 270         


Arg Gln His Arg Trp Met Arg Ala Glu Pro Cys Leu Pro Gly Pro Ala 
        275                 280                 285             


Cys Pro Ala Phe Ser Ala His Ser Tyr Thr Ser Asn Leu Gly Asp Tyr 
    290                 295                 300                 


Asp Glu Gln Ala Leu Gly Ile Met Gln Thr Leu Gly Val Asp Arg Gln 
305                 310                 315                 320 


Arg Thr Val Glu Ser Leu Gln Asn Ser Ser Tyr Asn His Phe Ala Ala 
                325                 330                 335     


Ile Tyr Tyr Leu Leu Leu Glu Arg Leu Lys Glu Tyr Arg Asn Ala Gln 
            340                 345                 350         


Cys Ala Arg Pro Gly Pro Ala Arg Gln Pro Arg Pro Arg Ser Ser Asp 
        355                 360                 365             


Leu Ser Gly Leu Glu Val Pro Gln Glu Gly Leu Ser Thr Asp Pro Phe 
    370                 375                 380                 


Arg Pro Ala Leu Leu Cys Pro Gln Pro Gln Thr Leu Val Gln Ser Val 
385                 390                 395                 400 


Leu Gln Ala Glu Met Asp Cys Glu Leu Gln Ser Ser Leu Gln Trp Pro 
                405                 410                 415     


Leu Phe Phe Pro Val Asp Ala Ser Cys Ser Gly Val Phe Arg Pro Arg 
            420                 425                 430         


Pro Val Ser Pro Ser Ser Leu Leu Asp Thr Ala Ile Ser Glu Glu Ala 
        435                 440                 445             


Arg Gln Gly Pro Gly Leu Glu Glu Glu Gln Asp Thr Gln Glu Ser Leu 
    450                 455                 460                 


Pro Ser Ser Thr Gly Arg Arg His Thr Leu Ala Glu Val Ser Thr Arg 
465                 470                 475                 480 


Leu Ser Pro Leu Thr Ala Pro Cys Ile Val Val Ser Pro Ser Thr Thr 
                485                 490                 495     


Ala Ser Pro Ala Glu Gly Thr Ser Ser Asp Ser Cys Leu Thr Phe Ser 
            500                 505                 510         


Ala Ser Lys Ser Pro Ala Gly Leu Ser Gly Thr Pro Ala Thr Gln Gly 
        515                 520                 525             


Leu Leu Gly Ala Cys Ser Pro Val Arg Leu Ala Ser Pro Phe Leu Gly 
    530                 535                 540                 


Ser Gln Ser Ala Thr Pro Val Leu Gln Ala Gln Gly Gly Leu Gly Gly 
545                 550                 555                 560 


Ala Val Leu Leu Pro Val Ser Phe Gln Glu Gly Arg Arg Ala Ser Asp 
                565                 570                 575     


Thr Ser Leu Thr Gln Gly Leu Lys Ala Phe Arg Gln Gln Leu Arg Lys 
            580                 585                 590         


Thr Thr Arg Thr Lys Gly Phe Leu Gly Leu Asn Lys Ile Lys Gly Leu 
        595                 600                 605             


Ala Arg Gln Val Cys Gln Val Pro Ala Ser Arg Ala Ser Arg Gly Gly 
    610                 615                 620                 


Leu Ser Pro Phe His Ala Pro Ala Gln Ser Pro Gly Leu His Gly Gly 
625                 630                 635                 640 


Ala Ala Gly Ser Arg Glu Gly Trp Ser Leu Leu Glu Glu Val Leu Glu 
                645                 650                 655     


Gln Gln Arg Leu Leu Gln Leu Gln His His Pro Ala Ala Ala Pro Gly 
            660                 665                 670         


Cys Ser Gln Ala Pro Gln Pro Ala Pro Ala Pro Phe Val Ile Ala Pro 
        675                 680                 685             


Cys Asp Gly Pro Gly Ala Ala Pro Leu Pro Ser Thr Leu Leu Thr Ser 
    690                 695                 700                 


Gly Leu Pro Leu Leu Pro Pro Pro Leu Leu Gln Thr Gly Ala Ser Pro 
705                 710                 715                 720 


Val Ala Ser Ala Ala Gln Leu Leu Asp Thr His Leu His Ile Gly Thr 
                725                 730                 735     


Gly Pro Thr Ala Leu Pro Ala Val Pro Pro Pro Arg Leu Ala Arg Leu 
            740                 745                 750         


Ala Pro Gly Cys Glu Pro Leu Gly Leu Leu Gln Gly Asp Cys Glu Met 
        755                 760                 765             


Glu Asp Leu Met Pro Cys Ser Leu Gly Thr Phe Val Leu Val Gln 
    770                 775                 780             


<210>  3970
<211>  3013
<212>  DNA
<213>  Homosapiens

<400>  3970
cattgccctc tgccccgcag cctgcccgtt cccaggccag cgagggcgct cccaggccgg     60

tctgcagcca gaacacagcc cgttccatgt gcttgtcctc gggacacatt aggaatgaac    120

ccaggcctca gtcctggcct cctcctcaag gctgggtgct cagacgtccc cctcagcccc    180

tttctctaga ccttccggct gaacaaacga gaacatctca cagccctgca acagccagga    240

gctgctcgtg gagctccacg cccggctgga gagagaggag gcaccctggg cagcccgcca    300

gcacccaggc tctcacagtg gaagcccacg tcttcttggg ctctattttg aaagctgttc    360

tttccacgac ggctttgaca agaatcgatt tgagtgagcc ggcgtgtcaa tacaggccag    420

cacaggactg gcctcagggc cacattgggg agggtggcga ccaggccctg gctgcagccc    480

acgtgggcaa aagcatggcc aggcaggagg tggggcctgt gagcttggct acagcgaccg    540

tgggcgctgg gcccggggct cctcagccct gaggggagac ccaggcccag gcaggctccc    600

aggcgggctc ccgggctccc agccttccga tcttctccct ttgagacctt gccttctgca    660

cagtgacagg aaagagccct gagtcccact ttgcagggat gtattgcatt tccagaaagt    720

tccttccggg tgcagagtga tacatgaacc ctggggactc actccaactt ggtattgatt    780

ttctccacgg aggacccagc agtcacggcc cgtgtctgca cagccccttg gatcctgcgg    840

aggaattcag ccggcccctc cccctgtgcc gaaaaccacg gaggcaaagc caggccaggg    900

tacagtgaga acacgggaga ggactgagag accgctggct gccgagggag gaagagcagg    960

attcgcaccc ccgtcatcgc tgggcccaca cgccgccgac agcttccgcg tgtggccatc   1020

tgtctttcag aaactctctg gcagagggac ccagcagatg acacgggggc cgttcacact   1080

ctgaaacctg cctggagtca aaacactgct ggcgagcctc caccgcaaac ccaatccaga   1140

tggtcttccc tggtggccct cggggtggcg ggcaccctgc ccactccctg ccagcccctg   1200

cccgctggac tccaggcccg gtcgagcccc cgaccggtct cctgacccag catgctgctc   1260

tcccctgggc ccggcttcct cgcccgctgg gactcccagg cccctccagc ccagccccga   1320

gagcaggagc cccaagggag gcttggcggc tgtggaggcg agtgggccac gtgtagctgg   1380

gaggccggca ggaccaggag cccctcacag cgcagcaccc acagcatcac gagccacttc   1440

cactcctggg tggcctgggg gcccccaccc tgctctgagc tgccccttgt tgtgacctgg   1500

ggtcccccgt ggtgggcccg ccccttgagc ctgggatcca gcctcagcga ggctccagaa   1560

gtgtcgtctc cgccggccag gcgtcagcgc ctccacccag gatcacacac tcctatctct   1620

gcacttctgc cctccatcct gctccacgcc gcctctgctt gttattccag cacattccag   1680

ggtgatgcct gctgaagcca cgcagccagt gcctccaccc taccccccat ctgacccacc   1740

ggccccttcc gcacgctgga agcctgcccg gcctgaagtg tcctcacctg tcgccctatc   1800

ctcccctcca ctccagccca ccggtgactc agccctcaca gctctctcct ccccgaggga   1860

gccggtgact tggctctgat ggtgccggga cccagccccg gcatgttcag aatccttgtc   1920

ctttaacctg cgtccacatg tagtcgcctc cacctccctg cctgaacctc caggccctgc   1980

agagcaaaca ctgctgcctg caggagaccc ctggggcctt ctccgtcccc tcatcctcct   2040

aaggagcctc ccctgccacc gtgccagaat gtgccggagg aacagaggcc cgagcctccc   2100

gtggccccag cgaggcttcc tctggggaag acagtgagcc caacgccctg gctctcgagg   2160

ggtggacgga gtccagctgg catcaaccgg gtgcccctct tcaccggtgt ccacagtcct   2220

tgagagcaaa gggttcccag aggcgacctc cctcctgcac aggcatttgt catccttacc   2280

ctctaggaca gctttgccat gtgcagtgaa cccctggaca gtgttgcgtg ccactttgcc   2340

ggatttggac tgtatacaga ccgaagcatg tggcatgaag ccttctgctg tcagcaagtt   2400

ccttgtccct cgacagtatg tgcccaggct gcccttcaag gtggcagtga tggcagttgt   2460

ctcttgcacg ctgcgtacag ttctgtcact gactcttaca cacagccctg gagacgggag   2520

agtgccggga gcattctatg caagtgtcct ggcctttgcg ggcgtctcca cagcacaaac   2580

acgagtcagg gaccacccct cttctgcttc catgattcca ccaactgggt ggggcagagc   2640

agtgccaggg ccggaggcac gccccaggtg agggcaggtg gccatgccag tgagtgcact   2700

gcgttctcag ttaattcatc cgaaatattt ctaagtttct tgattattgc agttgcatcc   2760

ccaagataat gccgccctca ccaagtagaa ggcacatgtg ctctgatggc ccctcccaca   2820

ctggggtcag ggcacagcaa cttagcgagg cgacgtgggg gctcagagga cctcggacca   2880

ggctcggcac atggggcttc tccagccagc cagggggaag caccctgcag actgctaact   2940

tttgcaaaat agagtaaaaa agatcagcta gaaaaataaa acaaaaaagg aaagatatac   3000

aaaatacaag gcc                                                      3013


<210>  3971
<211>  161
<212>  PRT
<213>  Homosapiens

<400>  3971

Met Cys Leu Ser Ser Gly His Ile Arg Asn Glu Pro Arg Pro Gln Ser 
1               5                   10                  15      


Trp Pro Pro Pro Gln Gly Trp Val Leu Arg Arg Pro Pro Gln Pro Leu 
            20                  25                  30          


Ser Leu Asp Leu Pro Ala Glu Gln Thr Arg Thr Ser His Ser Pro Ala 
        35                  40                  45              


Thr Ala Arg Ser Cys Ser Trp Ser Ser Thr Pro Gly Trp Arg Glu Arg 
    50                  55                  60                  


Arg His Pro Gly Gln Pro Ala Ser Thr Gln Ala Leu Thr Val Glu Ala 
65                  70                  75                  80  


His Val Phe Leu Gly Ser Ile Leu Lys Ala Val Leu Ser Thr Thr Ala 
                85                  90                  95      


Leu Thr Arg Ile Asp Leu Ser Glu Pro Ala Cys Gln Tyr Arg Pro Ala 
            100                 105                 110         


Gln Asp Trp Pro Gln Gly His Ile Gly Glu Gly Gly Asp Gln Ala Leu 
        115                 120                 125             


Ala Ala Ala His Val Gly Lys Ser Met Ala Arg Gln Glu Val Gly Pro 
    130                 135                 140                 


Val Ser Leu Ala Thr Ala Thr Val Gly Ala Gly Pro Gly Ala Pro Gln 
145                 150                 155                 160 


Pro 
    


<210>  3972
<211>  579
<212>  DNA
<213>  Homosapiens

<400>  3972
ctagagagct ggcgcacctc ctgggcctga cgcgggcttc ctggattgca taaaggctcc     60

ttctccttac atagccaggg caaaggtgca tgacaactct gagcaagtca aaacaaccgt    120

cagcagcggg aaacctcgat gaacaaacac cgggagagtg tttctgcaga tcctgctttg    180

tgacttcgag tgaagtgtgg aagcgctgga agcacttaga ccctgcctgt gccgcagacc    240

cctgggaggc accaacaccc cggatcgaga agcccgatgg gaaagaatgt ctgggaagga    300

cgtcatgccc gaggcttgcg tgacagtttc cactcacagt gcgctcactc tgaacctctg    360

tgcacacgat gggcctgcat ctcttcccac tatctgctag gaaacacgag gggaaggaaa    420

tgaccgcaga agggagtgca ccgtgggggc aggaggtgct gcggccaatg ggcagtgctg    480

ggagatgaaa ccaacagcgg cgattgcccc agaaagaact tggcgctgct aaggcaatgg    540

cggcccgaaa gaggcccctg acgcatgagg agcggccgc                           579


<210>  3973
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  3973

Met Thr Thr Leu Ser Lys Ser Lys Gln Pro Ser Ala Ala Gly Asn Leu 
1               5                   10                  15      


Asp Glu Gln Thr Pro Gly Glu Cys Phe Cys Arg Ser Cys Phe Val Thr 
            20                  25                  30          


Ser Ser Glu Val Trp Lys Arg Trp Lys His Leu Asp Pro Ala Cys Ala 
        35                  40                  45              


Ala Asp Pro Trp Glu Ala Pro Thr Pro Arg Ile Glu Lys Pro Asp Gly 
    50                  55                  60                  


Lys Glu Cys Leu Gly Arg Thr Ser Cys Pro Arg Leu Ala 
65                  70                  75          


<210>  3974
<211>  1916
<212>  DNA
<213>  Homosapiens

<400>  3974
ggagtgagcg cggcagtggc cctggcagct ggcggagcgg cccagcccgt gtgcacgtgg     60

cgccggcgct gcctttcggt tgccaaaatt caggctgtag acggcgagat aacaagttta    120

aaaccccggc taagccagaa gagccaaaga gggacctcgc caaggccact cctcgctctc    180

taggccgaga atactgcgca aattctggga ggtttgggcc tggcggctct ccgttcccga    240

cccccggcgt ggattcgttc ccgcgctttc tggcgtgagg ggtcagaggg cgcgccgacg    300

ctcaggcgaa cggagcggag gcggcagcgg ccatgggcga agcgggcgcc gctgaggagg    360

cctgccggca catgggaact aaagaggaat ttgttaaagt cagaaagaag gatctggaac    420

ggctgacaac tgaagtgatg caaatacggg acttcttacc cagaatacta aatggggagg    480

tgctggagag cttccagaaa ttaaagattg tagaaaaaaa cctggaaagg aaagagcaag    540

aattagagca gctgaaaatg gattgtgagc actttaaagc ccgcctggaa accgtgcagg    600

ccgacaacat aagagagaag aaggagaaac tggctcttcg acagcagttg aatgaagcga    660

agcagcaact cctgcagcag gcagagtatt gtacagaaat gggagcagca gcgtgtaccc    720

tcttgtgggg tgtctccagc agtgaggaag tcgtcaaggc cattttggga ggagataaag    780

ctttgaagtt tttcagcatc actggtcaaa caatggagag ttttgtgaag tcgttagacg    840

gtgatgtcca ggagctggat tcggatgaaa gtcagtttgt tttcgctctg gctggaattg    900

tcacgaatgt tgctgctata gcatgtggtc gtgaattctt ggttaattca agccgggtgc    960

tcttggacac catattgcag cttctgggag acttgaagcc aggacagtgt accaaactca   1020

aagtgctaat gctgatgtcc ctatacaatg taagcatcaa tttgaaaggc ttgaaataca   1080

tcagcgagag tccaggattc atccctttgc tgtggtggct tttgagtgat ccagatgcag   1140

aggtgtgcct tcatgtactg aggcttgtcc agtctgtggt tctggaacct gaagtcttct   1200

ccaagtcggc ctctgagttc cggagctccc tgcccctgca acgcatcctg gcaatgtcca   1260

agagccgcaa cccccgcctg caaaccgcag cccaggagct cctggaagat ctccgcactc   1320

tggagcataa tgtgtaggtg tgctcggcca ccagggtttt ggtgaaaatg ccggtgtccc   1380

ttctccccag atccctcatt tgatactcca aaaccatcac catgtaccat gtgttagagt   1440

tggcaaaatg tgattgacta gagatggaca tgaattgata tgtatcccac ataactttgt   1500

cttggaagtg agagtgcttg taggtggttg gttaagcttg ccaaaggaga ggccatgaaa   1560

gaacctgtcc ttctggaaaa gtggtccatg tctgtgctgg ctggaagagg gcttgcttag   1620

ggcagcttct tgctgctcag cagaccatga cctgtaggtt cacctataaa acagggaaat   1680

tgaataacca tctaccccat tagtcagcat tttcttgaga tacatttctt tgaaaagcaa   1740

ttcattctct ctctagtaat tgtaattaat ccccccaaaa tgcaagttta cttttataac   1800

cttttggtga acctgctatt tcggatgaca ttgggcattt tagttctata ttttttgtgc   1860

ctcttttatt tttgaataaa gaaaatcaga agagttgtaa aaaaaaaaaa aaaaaa       1916


<210>  3975
<211>  334
<212>  PRT
<213>  Homosapiens

<400>  3975

Met Gly Glu Ala Gly Ala Ala Glu Glu Ala Cys Arg His Met Gly Thr 
1               5                   10                  15      


Lys Glu Glu Phe Val Lys Val Arg Lys Lys Asp Leu Glu Arg Leu Thr 
            20                  25                  30          


Thr Glu Val Met Gln Ile Arg Asp Phe Leu Pro Arg Ile Leu Asn Gly 
        35                  40                  45              


Glu Val Leu Glu Ser Phe Gln Lys Leu Lys Ile Val Glu Lys Asn Leu 
    50                  55                  60                  


Glu Arg Lys Glu Gln Glu Leu Glu Gln Leu Lys Met Asp Cys Glu His 
65                  70                  75                  80  


Phe Lys Ala Arg Leu Glu Thr Val Gln Ala Asp Asn Ile Arg Glu Lys 
                85                  90                  95      


Lys Glu Lys Leu Ala Leu Arg Gln Gln Leu Asn Glu Ala Lys Gln Gln 
            100                 105                 110         


Leu Leu Gln Gln Ala Glu Tyr Cys Thr Glu Met Gly Ala Ala Ala Cys 
        115                 120                 125             


Thr Leu Leu Trp Gly Val Ser Ser Ser Glu Glu Val Val Lys Ala Ile 
    130                 135                 140                 


Leu Gly Gly Asp Lys Ala Leu Lys Phe Phe Ser Ile Thr Gly Gln Thr 
145                 150                 155                 160 


Met Glu Ser Phe Val Lys Ser Leu Asp Gly Asp Val Gln Glu Leu Asp 
                165                 170                 175     


Ser Asp Glu Ser Gln Phe Val Phe Ala Leu Ala Gly Ile Val Thr Asn 
            180                 185                 190         


Val Ala Ala Ile Ala Cys Gly Arg Glu Phe Leu Val Asn Ser Ser Arg 
        195                 200                 205             


Val Leu Leu Asp Thr Ile Leu Gln Leu Leu Gly Asp Leu Lys Pro Gly 
    210                 215                 220                 


Gln Cys Thr Lys Leu Lys Val Leu Met Leu Met Ser Leu Tyr Asn Val 
225                 230                 235                 240 


Ser Ile Asn Leu Lys Gly Leu Lys Tyr Ile Ser Glu Ser Pro Gly Phe 
                245                 250                 255     


Ile Pro Leu Leu Trp Trp Leu Leu Ser Asp Pro Asp Ala Glu Val Cys 
            260                 265                 270         


Leu His Val Leu Arg Leu Val Gln Ser Val Val Leu Glu Pro Glu Val 
        275                 280                 285             


Phe Ser Lys Ser Ala Ser Glu Phe Arg Ser Ser Leu Pro Leu Gln Arg 
    290                 295                 300                 


Ile Leu Ala Met Ser Lys Ser Arg Asn Pro Arg Leu Gln Thr Ala Ala 
305                 310                 315                 320 


Gln Glu Leu Leu Glu Asp Leu Arg Thr Leu Glu His Asn Val 
                325                 330                 


<210>  3976
<211>  6113
<212>  DNA
<213>  Homosapiens

<400>  3976
taatacttaa ttaccttcta ataattggag cagaagatga acccaactaa tcctttcagt     60

gggcagcagc ctagtgcttt ttcggcgtct tctagtaatg taggaacact tccatctaag    120

ccgccatttc gatttggtca accttctctt tttggacaaa acagtacctt atctgggaag    180

agctcgggat tttcacaggt atccagcttt ccagcgtctt ctggagtaag tcattcctct    240

tcagtgcaaa cattagggtt cacccaaacc tcaagtgttg gacccttttc tggacttgag    300

cacacttcca cctttgtggc tacctctggg ccttcaagtt catctgtgct gggaaacaca    360

ggatttagtt ttaaatcacc caccagtgtt ggggctttcc caagcacttc tgcttttgga    420

caagaagctg gagaaatagt gaactctggt tttgggaaaa cagaattcag ctttaaacct    480

ctggaaaatg cagtgttcaa accaatactg ggggctgaat ctgagccaga gaaaacccag    540

agccaaattg cttctgggtt ttttacattt tcccacccaa ttagtagtgc acctggaggc    600

ctggcccctt tctcttttcc tcaagtaaca agtagttcag ctaccacttc aaattttacc    660

ttttcaaaac ctgttagtag taataattca ttatctgcct ttacccctgc tttgtcaaac    720

caaaatgtag aggaagagaa gagaggacct aagtcaatat ttggaagttc taataatagc    780

ttcagtagct tccctgtatc atctgcggtt ttgggcgaac ctttccaggc tagcaaagca    840

ggtgtcaggc aggggtgtga agaagctgtt tcccaggtgg aaccacttcc cagcctaatg    900

aaaggactga aaaggaagga ggaccaggat cgctccccaa ggagacatgg ccacgagcca    960

gcagaagatt cggatcctct gtcccggggc gatcatcctc cagacaaacg acctgtccgc   1020

ctgaatcgac cccggggagg tactttattt ggtcggacga tacaggatgt tttcaaaagc   1080

aataaggaag taggtcgtct gggcaacaag gaggccaaaa aggaaactgg ctttgttgag   1140

tctgcagaaa gtgaccacat ggctatccca ggagggaatc agtctgtcct ggcaccttcc   1200

cggattccag gtgtgaataa agaggaagaa actgaaagta gagagaagaa agaagattct   1260

ctaagaggaa ctccggcgcg tcagagtaac agaagcgaga gcacagacag tcttgggggc   1320

ttgtctccct ctgaagtcac agccatccag tgcaagaaca tccctgacta cctcaacgac   1380

aggaccattc tggagaacca ttttggcaaa attgctaaag tgcagcgcat ctttaccagg   1440

cgcagcaaaa agcttgcagt ggtacatttc tttgatcatg catctgcagc cctggctaga   1500

aagaagggga aaagtttgca taaagacatg gctatctttt ggcacaggaa gaaaataagc   1560

cccaataaga aacccttttc cctgaaggag aagaaaccag gtgacggtga agtcagcccg   1620

agcacagagg atgcaccctt tcagcactct cctcttggca aggccgcagg gaggactggt   1680

gctagcagcc tcctgaataa aagctctcca gtgaagaagc caagtcttct aaaggcccac   1740

caattcgagg gagactcttt tgactcagcc tccgagggct ccgagggcct cgggccatgt   1800

gtgctctccc tcagtaccct gataggcact gtggctgaga catccaagga gaagtaccgc   1860

ctgcttgacc agagagacag gatcatgcgg caagctcggg tgaagagaac cgatctggac   1920

aaagcgagga cttttgttgg cacctgcctg gatatgtgtc ctgagaagga gaggtacatg   1980

cgggagaccc gtagccagct gagcgtgttc gaagtggtcc cagggactga ccaggtggac   2040

cacgcagcag ctgtgaaaga gtacagtcgg tcctcggcgg atcaggagga gcccctgccc   2100

cacgagctgc ggcccttgcc agtgctcagc aggaccatgg actacctggt gacccagatc   2160

atggaccaga aggagggcag cctgcgggat tggtatgact tcgtgtggaa ccgcacgcgt   2220

ggcatacgga aggatatcac gcagcagcac ctctgtgacc ccctgacggt gtccctgatt   2280

gagaagtgca cccggtttca catccactgt gcccacttca tgtgtgagga gcccatgtcc   2340

tcctttgatg ccaagatcaa taatgagaac atgaccaagt gcctgcagag cctgaaggag   2400

atgtaccagg acctgagaaa caagggtgtc ttctgtgcca gcgaagcgga gttccagggc   2460

tacaatgttc tgctcagtct caacaaggga gacatcctaa gagaagtaca acagttccat   2520

cctgctgtta gaaactcatc tgaggtgaaa tttgctgttc aggcttttgc tgcattgaac   2580

agtaataatt ttgtgagatt tttcaaactg gtccagtcag cttcttacct gaacgcttgt   2640

cttttacact gttacttcag tcagatccgc aaggatgctc tccgggcgct caactttgcg   2700

tacacggtga gcacacagcg atctaccatc tttcccctgg atggtgtggt gcgcatgctg   2760

ctgttcagag actgtgaaga ggccaccgac ttcctcacct gccacggcct caccgtttcc   2820

gacggctgtg tggagctgaa ccggtctgca ttcctggaac cagagggatt atccaagacc   2880

aggaagtcgg tgtttattac taggaagctg acggtgtcag tcggggaaat tgtgaacgga   2940

gggccattgc cccccgtccc tcgtcatacc cctgtgtgca gcttcaactc ccagaacaag   3000

tacatcgggg agagcctggc cgcggagctg cccgtcagca cccagagacc cggctccgac   3060

acagtgggcg gagggagagg agaggagtgt ggtgtagagc cggatgcacc cctgtccagt   3120

ctcccacagt ctctaccagc ccctgcgccc tcaccagtgc ctctgcctcc tgtcctggca   3180

ctgaccccgt ctgtggcgcc cagcctcttc cagctgtctg tgcagcctga accaccgcct   3240

ccagagcccg tgcccatgta ctctgacgag gacctggcgc aggtggtgga cgagctcatc   3300

caggaggccc tgcagaggga ctgtgaggaa gttggctctg cgggtgctgc ctacgcagct   3360

gccgccctgg gtgtttctaa tgctgctatg gaggatttgt taacagctgc aaccacgggc   3420

attttgaggc acattgcagc tgaagaagtg tctaaggaaa gagagcgaag ggagcaggag   3480

aggcagcggg ctgaagagga aaggttgaaa caagagagag agctggtgtt aagtgagctg   3540

agccagggcc tggccgtgga gctgatggaa cgcgtgatga tggagtttgt gagggaaacc   3600

tgctcccagg agttgaagaa tgcagtagag acagaccaga gggtccgtgt ggcccgttgc   3660

tgtgaggatg tctgtgccca cttagtggac ttgtttctcg tggaggaaat cttccagact   3720

gcaaaggaga ccctccagga gcttcagtgc ttctgcaagt atctacagcg gtggagggaa   3780

gctgtcacag cccgcaagaa actgaggcgc caaatgcggg ctttccctgc tgcgccctgc   3840

tgcgtggacg tgagcgaccg gctgagggcg ctggcgccca gcgcagagtg ccccattgct   3900

gaagagaacc tggccagggg cctcctggac ctgggccatg cagggagatt gggcatctcc   3960

tgcaccaggt taaggcggct cagaaacaag acagctcacc agatgaaggt tcagcacttc   4020

taccagcagc tgctgagtga tgtggcatgg gcgtctctgg acctgccatc cctcgtggct   4080

gagcacctcc ctgggaggca ggagcatgtg ttttggaagc tggtgctggt gttgccggat   4140

gtagaggagc agtccccaga gagttgtggc agaattctag caaattggtt aaaagtcaag   4200

ttcatgggag atgaaggctc agtggatgac acatccagcg atgctggtgg gattcagacg   4260

ctttcgcttt tcaactcact tagcagcaaa ggggatcaga tgatttctgt taacgtgtgt   4320

ataaaggtgg cccatggcgc cctcagtgat ggtgccattg atgctgtgga gacacagaag   4380

gacctcctgg gagccagtgg gctcatgctg ctgcttcccc ccaaaatgaa gagtgaggac   4440

atggcagagg aggacgtgta ctggctgtcg gccttgctgc agctcaagca gctcctgcag   4500

gctaagccct tccagcctgc gcttcctctg gtggttcttg tgcctagccc aggaggggac   4560

gccgttgaga aggaagtaga agatggtctg atgctacagg acttggtttc agctaagctg   4620

atttcagatt acactgttac cgagatccct gataccatta atgatctaca aggttcaact   4680

aaggttttgc aagcagtgca gtggctggtt tcccactgcc cccattccct tgacctctgc   4740

tgccagactc tcattcagta cgtcgaagac gggattggcc atgagtttag tggccgcttt   4800

ttccatgaca gaagagagag gcgtctgggc ggtcttgctt ctcaggagcc tggcgccatc   4860

attgagctgt ttaacagtgt gctgcagttc ctggcttctg tggtgtcctc tgaacagctg   4920

tgtgacctgt cctggcctgt cactgagttt gctgaggcag ggggcagccg gctgcttcct   4980

cacctgcact ggaatgcccc agagcacctg gcctggctga agcaggctgt gctcgggttc   5040

cagcttccgc agatggacct tccacccctg ggggccccct ggctccccgt gtgctccatg   5100

gttgtccagt acgcctccca gatccccagc tcacgccaga cacagcctgt cctccagtcc   5160

caggtggaga acctgctcca cagaacctac tgtaggtgga agagcaagag tccctcccca   5220

gtccatgggg caggcccctc ggtcatggag atcccatggg atgatcttat cgccttgtgt   5280

atcaaccaca agctgagaga ctggacgccc ccccggcttc ctgttacatc agaggcgctg   5340

agtgaagatg gtcagatatg tgtgtatttt tttaaaaacg atttgaaaaa atatgatgtt   5400

cctttgtcgt gggaacaagc caggttgcag acgcagaagg agctacagct gagagaggga   5460

cgtttggcaa taaagccttt tcatccttct gcaaacaatt ttcccatacc attgcttcac   5520

atgcaccgta actggaagag gagcacagag tgtgctcaag aggggaggat tcccagcaca   5580

gaggatctga tgcgaggagc ttctgctgag gagctcttgg cgcagtgttt gtcgagcagt   5640

ctgctgctgg agaaagaaga gaacaagagg tttgaagatc agcttcagca atggttgtct   5700

gaagactcag gagcatttac ggatttaact tcccttcccc tctatcttcc tcagactcta   5760

gtgtctcttt ctcacactat tgaacctgtg atgaaaacat ctgtaactac tagcccacag   5820

agtgacatga tgagggagca actgcagctg tcagaggcga caggaacgtg tctaggcgaa   5880

cgactaaagc acctggaaag gctgatccgg agttcaaggg aagaggaagt tgcctctgag   5940

ctccatctct ctgcgctgct agacatggtg gacatttgag cagcctgacc tgtggggagg   6000

gggtctctcc cgaagagttt ctgtttttac tcaaaataat gttattctca gatgcttgat   6060

gcactgttgg aaatgtgatt aatttaatca tgcagataaa ccatttaaat gtc          6113


<210>  3977
<211>  1980
<212>  PRT
<213>  Homosapiens

<400>  3977

Met Asn Pro Thr Asn Pro Phe Ser Gly Gln Gln Pro Ser Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ser Ser Asn Val Gly Thr Leu Pro Ser Lys Pro Pro Phe Arg 
            20                  25                  30          


Phe Gly Gln Pro Ser Leu Phe Gly Gln Asn Ser Thr Leu Ser Gly Lys 
        35                  40                  45              


Ser Ser Gly Phe Ser Gln Val Ser Ser Phe Pro Ala Ser Ser Gly Val 
    50                  55                  60                  


Ser His Ser Ser Ser Val Gln Thr Leu Gly Phe Thr Gln Thr Ser Ser 
65                  70                  75                  80  


Val Gly Pro Phe Ser Gly Leu Glu His Thr Ser Thr Phe Val Ala Thr 
                85                  90                  95      


Ser Gly Pro Ser Ser Ser Ser Val Leu Gly Asn Thr Gly Phe Ser Phe 
            100                 105                 110         


Lys Ser Pro Thr Ser Val Gly Ala Phe Pro Ser Thr Ser Ala Phe Gly 
        115                 120                 125             


Gln Glu Ala Gly Glu Ile Val Asn Ser Gly Phe Gly Lys Thr Glu Phe 
    130                 135                 140                 


Ser Phe Lys Pro Leu Glu Asn Ala Val Phe Lys Pro Ile Leu Gly Ala 
145                 150                 155                 160 


Glu Ser Glu Pro Glu Lys Thr Gln Ser Gln Ile Ala Ser Gly Phe Phe 
                165                 170                 175     


Thr Phe Ser His Pro Ile Ser Ser Ala Pro Gly Gly Leu Ala Pro Phe 
            180                 185                 190         


Ser Phe Pro Gln Val Thr Ser Ser Ser Ala Thr Thr Ser Asn Phe Thr 
        195                 200                 205             


Phe Ser Lys Pro Val Ser Ser Asn Asn Ser Leu Ser Ala Phe Thr Pro 
    210                 215                 220                 


Ala Leu Ser Asn Gln Asn Val Glu Glu Glu Lys Arg Gly Pro Lys Ser 
225                 230                 235                 240 


Ile Phe Gly Ser Ser Asn Asn Ser Phe Ser Ser Phe Pro Val Ser Ser 
                245                 250                 255     


Ala Val Leu Gly Glu Pro Phe Gln Ala Ser Lys Ala Gly Val Arg Gln 
            260                 265                 270         


Gly Cys Glu Glu Ala Val Ser Gln Val Glu Pro Leu Pro Ser Leu Met 
        275                 280                 285             


Lys Gly Leu Lys Arg Lys Glu Asp Gln Asp Arg Ser Pro Arg Arg His 
    290                 295                 300                 


Gly His Glu Pro Ala Glu Asp Ser Asp Pro Leu Ser Arg Gly Asp His 
305                 310                 315                 320 


Pro Pro Asp Lys Arg Pro Val Arg Leu Asn Arg Pro Arg Gly Gly Thr 
                325                 330                 335     


Leu Phe Gly Arg Thr Ile Gln Asp Val Phe Lys Ser Asn Lys Glu Val 
            340                 345                 350         


Gly Arg Leu Gly Asn Lys Glu Ala Lys Lys Glu Thr Gly Phe Val Glu 
        355                 360                 365             


Ser Ala Glu Ser Asp His Met Ala Ile Pro Gly Gly Asn Gln Ser Val 
    370                 375                 380                 


Leu Ala Pro Ser Arg Ile Pro Gly Val Asn Lys Glu Glu Glu Thr Glu 
385                 390                 395                 400 


Ser Arg Glu Lys Lys Glu Asp Ser Leu Arg Gly Thr Pro Ala Arg Gln 
                405                 410                 415     


Ser Asn Arg Ser Glu Ser Thr Asp Ser Leu Gly Gly Leu Ser Pro Ser 
            420                 425                 430         


Glu Val Thr Ala Ile Gln Cys Lys Asn Ile Pro Asp Tyr Leu Asn Asp 
        435                 440                 445             


Arg Thr Ile Leu Glu Asn His Phe Gly Lys Ile Ala Lys Val Gln Arg 
    450                 455                 460                 


Ile Phe Thr Arg Arg Ser Lys Lys Leu Ala Val Val His Phe Phe Asp 
465                 470                 475                 480 


His Ala Ser Ala Ala Leu Ala Arg Lys Lys Gly Lys Ser Leu His Lys 
                485                 490                 495     


Asp Met Ala Ile Phe Trp His Arg Lys Lys Ile Ser Pro Asn Lys Lys 
            500                 505                 510         


Pro Phe Ser Leu Lys Glu Lys Lys Pro Gly Asp Gly Glu Val Ser Pro 
        515                 520                 525             


Ser Thr Glu Asp Ala Pro Phe Gln His Ser Pro Leu Gly Lys Ala Ala 
    530                 535                 540                 


Gly Arg Thr Gly Ala Ser Ser Leu Leu Asn Lys Ser Ser Pro Val Lys 
545                 550                 555                 560 


Lys Pro Ser Leu Leu Lys Ala His Gln Phe Glu Gly Asp Ser Phe Asp 
                565                 570                 575     


Ser Ala Ser Glu Gly Ser Glu Gly Leu Gly Pro Cys Val Leu Ser Leu 
            580                 585                 590         


Ser Thr Leu Ile Gly Thr Val Ala Glu Thr Ser Lys Glu Lys Tyr Arg 
        595                 600                 605             


Leu Leu Asp Gln Arg Asp Arg Ile Met Arg Gln Ala Arg Val Lys Arg 
    610                 615                 620                 


Thr Asp Leu Asp Lys Ala Arg Thr Phe Val Gly Thr Cys Leu Asp Met 
625                 630                 635                 640 


Cys Pro Glu Lys Glu Arg Tyr Met Arg Glu Thr Arg Ser Gln Leu Ser 
                645                 650                 655     


Val Phe Glu Val Val Pro Gly Thr Asp Gln Val Asp His Ala Ala Ala 
            660                 665                 670         


Val Lys Glu Tyr Ser Arg Ser Ser Ala Asp Gln Glu Glu Pro Leu Pro 
        675                 680                 685             


His Glu Leu Arg Pro Leu Pro Val Leu Ser Arg Thr Met Asp Tyr Leu 
    690                 695                 700                 


Val Thr Gln Ile Met Asp Gln Lys Glu Gly Ser Leu Arg Asp Trp Tyr 
705                 710                 715                 720 


Asp Phe Val Trp Asn Arg Thr Arg Gly Ile Arg Lys Asp Ile Thr Gln 
                725                 730                 735     


Gln His Leu Cys Asp Pro Leu Thr Val Ser Leu Ile Glu Lys Cys Thr 
            740                 745                 750         


Arg Phe His Ile His Cys Ala His Phe Met Cys Glu Glu Pro Met Ser 
        755                 760                 765             


Ser Phe Asp Ala Lys Ile Asn Asn Glu Asn Met Thr Lys Cys Leu Gln 
    770                 775                 780                 


Ser Leu Lys Glu Met Tyr Gln Asp Leu Arg Asn Lys Gly Val Phe Cys 
785                 790                 795                 800 


Ala Ser Glu Ala Glu Phe Gln Gly Tyr Asn Val Leu Leu Ser Leu Asn 
                805                 810                 815     


Lys Gly Asp Ile Leu Arg Glu Val Gln Gln Phe His Pro Ala Val Arg 
            820                 825                 830         


Asn Ser Ser Glu Val Lys Phe Ala Val Gln Ala Phe Ala Ala Leu Asn 
        835                 840                 845             


Ser Asn Asn Phe Val Arg Phe Phe Lys Leu Val Gln Ser Ala Ser Tyr 
    850                 855                 860                 


Leu Asn Ala Cys Leu Leu His Cys Tyr Phe Ser Gln Ile Arg Lys Asp 
865                 870                 875                 880 


Ala Leu Arg Ala Leu Asn Phe Ala Tyr Thr Val Ser Thr Gln Arg Ser 
                885                 890                 895     


Thr Ile Phe Pro Leu Asp Gly Val Val Arg Met Leu Leu Phe Arg Asp 
            900                 905                 910         


Cys Glu Glu Ala Thr Asp Phe Leu Thr Cys His Gly Leu Thr Val Ser 
        915                 920                 925             


Asp Gly Cys Val Glu Leu Asn Arg Ser Ala Phe Leu Glu Pro Glu Gly 
    930                 935                 940                 


Leu Ser Lys Thr Arg Lys Ser Val Phe Ile Thr Arg Lys Leu Thr Val 
945                 950                 955                 960 


Ser Val Gly Glu Ile Val Asn Gly Gly Pro Leu Pro Pro Val Pro Arg 
                965                 970                 975     


His Thr Pro Val Cys Ser Phe Asn Ser Gln Asn Lys Tyr Ile Gly Glu 
            980                 985                 990         


Ser Leu Ala Ala Glu Leu Pro Val  Ser Thr Gln Arg Pro  Gly Ser Asp 
        995                 1000                 1005             


Thr Val  Gly Gly Gly Arg Gly  Glu Glu Cys Gly Val  Glu Pro Asp 
    1010                 1015                 1020             


Ala Pro  Leu Ser Ser Leu Pro  Gln Ser Leu Pro Ala  Pro Ala Pro 
    1025                 1030                 1035             


Ser Pro  Val Pro Leu Pro Pro  Val Leu Ala Leu Thr  Pro Ser Val 
    1040                 1045                 1050             


Ala Pro  Ser Leu Phe Gln Leu  Ser Val Gln Pro Glu  Pro Pro Pro 
    1055                 1060                 1065             


Pro Glu  Pro Val Pro Met Tyr  Ser Asp Glu Asp Leu  Ala Gln Val 
    1070                 1075                 1080             


Val Asp  Glu Leu Ile Gln Glu  Ala Leu Gln Arg Asp  Cys Glu Glu 
    1085                 1090                 1095             


Val Gly  Ser Ala Gly Ala Ala  Tyr Ala Ala Ala Ala  Leu Gly Val 
    1100                 1105                 1110             


Ser Asn  Ala Ala Met Glu Asp  Leu Leu Thr Ala Ala  Thr Thr Gly 
    1115                 1120                 1125             


Ile Leu  Arg His Ile Ala Ala  Glu Glu Val Ser Lys  Glu Arg Glu 
    1130                 1135                 1140             


Arg Arg  Glu Gln Glu Arg Gln  Arg Ala Glu Glu Glu  Arg Leu Lys 
    1145                 1150                 1155             


Gln Glu  Arg Glu Leu Val Leu  Ser Glu Leu Ser Gln  Gly Leu Ala 
    1160                 1165                 1170             


Val Glu  Leu Met Glu Arg Val  Met Met Glu Phe Val  Arg Glu Thr 
    1175                 1180                 1185             


Cys Ser  Gln Glu Leu Lys Asn  Ala Val Glu Thr Asp  Gln Arg Val 
    1190                 1195                 1200             


Arg Val  Ala Arg Cys Cys Glu  Asp Val Cys Ala His  Leu Val Asp 
    1205                 1210                 1215             


Leu Phe  Leu Val Glu Glu Ile  Phe Gln Thr Ala Lys  Glu Thr Leu 
    1220                 1225                 1230             


Gln Glu  Leu Gln Cys Phe Cys  Lys Tyr Leu Gln Arg  Trp Arg Glu 
    1235                 1240                 1245             


Ala Val  Thr Ala Arg Lys Lys  Leu Arg Arg Gln Met  Arg Ala Phe 
    1250                 1255                 1260             


Pro Ala  Ala Pro Cys Cys Val  Asp Val Ser Asp Arg  Leu Arg Ala 
    1265                 1270                 1275             


Leu Ala  Pro Ser Ala Glu Cys  Pro Ile Ala Glu Glu  Asn Leu Ala 
    1280                 1285                 1290             


Arg Gly  Leu Leu Asp Leu Gly  His Ala Gly Arg Leu  Gly Ile Ser 
    1295                 1300                 1305             


Cys Thr  Arg Leu Arg Arg Leu  Arg Asn Lys Thr Ala  His Gln Met 
    1310                 1315                 1320             


Lys Val  Gln His Phe Tyr Gln  Gln Leu Leu Ser Asp  Val Ala Trp 
    1325                 1330                 1335             


Ala Ser  Leu Asp Leu Pro Ser  Leu Val Ala Glu His  Leu Pro Gly 
    1340                 1345                 1350             


Arg Gln  Glu His Val Phe Trp  Lys Leu Val Leu Val  Leu Pro Asp 
    1355                 1360                 1365             


Val Glu  Glu Gln Ser Pro Glu  Ser Cys Gly Arg Ile  Leu Ala Asn 
    1370                 1375                 1380             


Trp Leu  Lys Val Lys Phe Met  Gly Asp Glu Gly Ser  Val Asp Asp 
    1385                 1390                 1395             


Thr Ser  Ser Asp Ala Gly Gly  Ile Gln Thr Leu Ser  Leu Phe Asn 
    1400                 1405                 1410             


Ser Leu  Ser Ser Lys Gly Asp  Gln Met Ile Ser Val  Asn Val Cys 
    1415                 1420                 1425             


Ile Lys  Val Ala His Gly Ala  Leu Ser Asp Gly Ala  Ile Asp Ala 
    1430                 1435                 1440             


Val Glu  Thr Gln Lys Asp Leu  Leu Gly Ala Ser Gly  Leu Met Leu 
    1445                 1450                 1455             


Leu Leu  Pro Pro Lys Met Lys  Ser Glu Asp Met Ala  Glu Glu Asp 
    1460                 1465                 1470             


Val Tyr  Trp Leu Ser Ala Leu  Leu Gln Leu Lys Gln  Leu Leu Gln 
    1475                 1480                 1485             


Ala Lys  Pro Phe Gln Pro Ala  Leu Pro Leu Val Val  Leu Val Pro 
    1490                 1495                 1500             


Ser Pro  Gly Gly Asp Ala Val  Glu Lys Glu Val Glu  Asp Gly Leu 
    1505                 1510                 1515             


Met Leu  Gln Asp Leu Val Ser  Ala Lys Leu Ile Ser  Asp Tyr Thr 
    1520                 1525                 1530             


Val Thr  Glu Ile Pro Asp Thr  Ile Asn Asp Leu Gln  Gly Ser Thr 
    1535                 1540                 1545             


Lys Val  Leu Gln Ala Val Gln  Trp Leu Val Ser His  Cys Pro His 
    1550                 1555                 1560             


Ser Leu  Asp Leu Cys Cys Gln  Thr Leu Ile Gln Tyr  Val Glu Asp 
    1565                 1570                 1575             


Gly Ile  Gly His Glu Phe Ser  Gly Arg Phe Phe His  Asp Arg Arg 
    1580                 1585                 1590             


Glu Arg  Arg Leu Gly Gly Leu  Ala Ser Gln Glu Pro  Gly Ala Ile 
    1595                 1600                 1605             


Ile Glu  Leu Phe Asn Ser Val  Leu Gln Phe Leu Ala  Ser Val Val 
    1610                 1615                 1620             


Ser Ser  Glu Gln Leu Cys Asp  Leu Ser Trp Pro Val  Thr Glu Phe 
    1625                 1630                 1635             


Ala Glu  Ala Gly Gly Ser Arg  Leu Leu Pro His Leu  His Trp Asn 
    1640                 1645                 1650             


Ala Pro  Glu His Leu Ala Trp  Leu Lys Gln Ala Val  Leu Gly Phe 
    1655                 1660                 1665             


Gln Leu  Pro Gln Met Asp Leu  Pro Pro Leu Gly Ala  Pro Trp Leu 
    1670                 1675                 1680             


Pro Val  Cys Ser Met Val Val  Gln Tyr Ala Ser Gln  Ile Pro Ser 
    1685                 1690                 1695             


Ser Arg  Gln Thr Gln Pro Val  Leu Gln Ser Gln Val  Glu Asn Leu 
    1700                 1705                 1710             


Leu His  Arg Thr Tyr Cys Arg  Trp Lys Ser Lys Ser  Pro Ser Pro 
    1715                 1720                 1725             


Val His  Gly Ala Gly Pro Ser  Val Met Glu Ile Pro  Trp Asp Asp 
    1730                 1735                 1740             


Leu Ile  Ala Leu Cys Ile Asn  His Lys Leu Arg Asp  Trp Thr Pro 
    1745                 1750                 1755             


Pro Arg  Leu Pro Val Thr Ser  Glu Ala Leu Ser Glu  Asp Gly Gln 
    1760                 1765                 1770             


Ile Cys  Val Tyr Phe Phe Lys  Asn Asp Leu Lys Lys  Tyr Asp Val 
    1775                 1780                 1785             


Pro Leu  Ser Trp Glu Gln Ala  Arg Leu Gln Thr Gln  Lys Glu Leu 
    1790                 1795                 1800             


Gln Leu  Arg Glu Gly Arg Leu  Ala Ile Lys Pro Phe  His Pro Ser 
    1805                 1810                 1815             


Ala Asn  Asn Phe Pro Ile Pro  Leu Leu His Met His  Arg Asn Trp 
    1820                 1825                 1830             


Lys Arg  Ser Thr Glu Cys Ala  Gln Glu Gly Arg Ile  Pro Ser Thr 
    1835                 1840                 1845             


Glu Asp  Leu Met Arg Gly Ala  Ser Ala Glu Glu Leu  Leu Ala Gln 
    1850                 1855                 1860             


Cys Leu  Ser Ser Ser Leu Leu  Leu Glu Lys Glu Glu  Asn Lys Arg 
    1865                 1870                 1875             


Phe Glu  Asp Gln Leu Gln Gln  Trp Leu Ser Glu Asp  Ser Gly Ala 
    1880                 1885                 1890             


Phe Thr  Asp Leu Thr Ser Leu  Pro Leu Tyr Leu Pro  Gln Thr Leu 
    1895                 1900                 1905             


Val Ser  Leu Ser His Thr Ile  Glu Pro Val Met Lys  Thr Ser Val 
    1910                 1915                 1920             


Thr Thr  Ser Pro Gln Ser Asp  Met Met Arg Glu Gln  Leu Gln Leu 
    1925                 1930                 1935             


Ser Glu  Ala Thr Gly Thr Cys  Leu Gly Glu Arg Leu  Lys His Leu 
    1940                 1945                 1950             


Glu Arg  Leu Ile Arg Ser Ser  Arg Glu Glu Glu Val  Ala Ser Glu 
    1955                 1960                 1965             


Leu His  Leu Ser Ala Leu Leu  Asp Met Val Asp Ile  
    1970                 1975                 1980 


<210>  3978
<211>  2991
<212>  DNA
<213>  Homosapiens

<400>  3978
caaaaagttc gcgctgctgg tcccgcgcgg gcggcccctg ggctttgtgt ccaccaggac     60

agcgggccgg gctccctgca ggcgcgggcg gcgccgaacg gtgctcagca accacccgga    120

cagggccagg ccgttttctc ccgctcaggc attagtcgtt ggctgtgggc cgccgcggga    180

agttgaggcc taccacggag gaggctgctg aggtggatct caggggatcc gcaagggctc    240

cctcaccctt gccgggaccc tgggaacccg aaacaaaatc ctacgccacc agcccgccga    300

atgcgccccc tcggccgggg gtcctgggtc ttcagagaag aactcggccg aatgcggtca    360

gaaagcccgc gaaccgcctg gacctgcagg ccccgccgct tggagctccc gcctttcccg    420

accgagcccg tgtctgctcg tgtgtctcac tgatgtctta ggtctcaaaa aaaaaagaaa    480

agaaaaggtt tttagtagac agaagagaaa tggggccgtg ggttcgtggt cccaggggga    540

aactgacgtc gcatgaggtc gtcgtccctc agcttgagct cagcggaaca taagcttgca    600

gaggtggaaa ccacggaagg tttgggtgtc ttggagctct ctggacaccg aagcccggac    660

acagtcccgg ggtccgcacc gcctgtgacc tgtggcggga ccgccggggt gggcgttttc    720

tcagctggcg cgcgcgtagg tggaacttgg gaaactaact ggagcgaagt ggcaaaaaac    780

caagacaggg ccggtgacct cgcgcaggcc gtccttaact gtggagtatt ccttcagcta    840

acccctttat ttcatgtgtc caagtctggt ttctgggttt ctttgtagtc cctccgggcc    900

tgttcgtgcg ccttcacttg caaaaggttc gtcgtggagg gccgtgtgct tgtttgcagc    960

agtaacgatg cccttcccga gcgtgctgga gtggctcctc gctgacgcaa gctcaccttg   1020

cagcctcctc agcaactgca acttaaacgc gccctcagga agccctggaa tctcgctcag   1080

aatttttttt ctttttttga gacagtctcg ctgcgacgcc caggctatag cgcaatggcg   1140

cgatctcggc tccctgcaac ctccctcagg aagccgtgga agctcgaccg ccagaaactt   1200

ccttctcctg actcaggcca cagtcttctg tgtggctggt ctccaggagg taaggcccgc   1260

cctgcaggca acaccggtgc ttgggctcct gctgagcagt tctttcctgc gagtaacaga   1320

accagggagg gaggtgggct gtggcctccc ctgcccctac agtcgtctcc tgcagctccc   1380

accatgctgg actcatcagc agcagagcaa gtgacccgac tgacgctgaa gctcttggga   1440

cagaagctgg agcaagaacg gcagaacgtg gaagggggac ctgagggcct ccacctcgag   1500

ccaggaaatg aggaccggcc ggacgatgcc ctgcagactg ctctgaagag aaggagggac   1560

cttctgcaga gactccggga acaacacctc ctggacgagc tctctcgggc ccaggcctgg   1620

agcgggccaa gcagaggagc cctcgggtca gccctgcccc cagagctgcc ccccacgggc   1680

atcctaccca ctgcctcccc atccccgctg gccccagacc cgccaaggat catcctgcct   1740

acggtccccc agcctcctgc caccatcatt cagcagctcc ctcagcagcc actcatagca   1800

cagattcctc ctccccaggc cttccctact caacggtcag gaagtattaa ggaagacatg   1860

gtggagctgc tgctgctgca gaacgcacag gtgcaccagt tggtcctgca gaactggatg   1920

ctcaaggccc tgcccccagc cctgcaggac ccgccacatg tgcccccgag ggtcccacga   1980

gctgccaggc caaggctgcc tgccgtgcac caccaccacc accaccacca tgctgtgtgg   2040

ccacctgggg ctgccactgt cctccagccc gcccccagcc tgtggacgcc tggcccaccc   2100

tgagtgtgag tcacagagac cctggccggg gcaccctcca cccccaggct tcctcagggc   2160

tgtgggctgt ggcgggacta tggaagggag cagggagaga ccctgccacc acccggagtg   2220

gctacgcgag tgtggactgc aggctcctcc tggggaagct gggcaggctc gctttctggt   2280

cacggggcca ttccaggggg catcccttgc tccgggtccc ctgcagtgag gggcctgtga   2340

accccaccag ggcaacagcc cctcccaggg acccctcctt tcctgtaggg cggcgccggc   2400

ccacctggga gcctcagatc cccctcttcc atcacggagg taaagttgag gccgtggacg   2460

ccaccagcct gatgaaataa agatttcatc cagaaagagt ttaagaaaat ctcagctcag   2520

gagccagaac agaaaagatc aatagcttta gccacatgga agtgtgaaca tcctgatggg   2580

gaaaatacca caaagtctaa tttaataact agggacacct gtgtgccaca gctgtggcac   2640

agactcccac taaagaagta ggggtgcatg gctcatgcct gtaatcccag cactttaaga   2700

ggctgaggca ggaggatcac ttgagctcag gaattcgaga ccagcctggg tcacatagca   2760

agaccccgtc tctacaaaaa ataaatttaa aaaactagcc aggtgtggtg atatgcgcct   2820

gttatctcag cagctctggg ggctgaggtg ggaggattgc ttgagcccag gagttagaag   2880

ctgcagtgag ctctgatgga accactgcac tatagcctgg accacagagc aggcccctgt   2940

ctcaaaaaat aaaataaaaa agtgaaagaa gaaaaaaaaa aaaaaaaaaa a            2991


<210>  3979
<211>  322
<212>  PRT
<213>  Homosapiens

<400>  3979

Met Ala Arg Ser Arg Leu Pro Ala Thr Ser Leu Arg Lys Pro Trp Lys 
1               5                   10                  15      


Leu Asp Arg Gln Lys Leu Pro Ser Pro Asp Ser Gly His Ser Leu Leu 
            20                  25                  30          


Cys Gly Trp Ser Pro Gly Gly Lys Ala Arg Pro Ala Gly Asn Thr Gly 
        35                  40                  45              


Ala Trp Ala Pro Ala Glu Gln Phe Phe Pro Ala Ser Asn Arg Thr Arg 
    50                  55                  60                  


Glu Gly Gly Gly Leu Trp Pro Pro Leu Pro Leu Gln Ser Ser Pro Ala 
65                  70                  75                  80  


Ala Pro Thr Met Leu Asp Ser Ser Ala Ala Glu Gln Val Thr Arg Leu 
                85                  90                  95      


Thr Leu Lys Leu Leu Gly Gln Lys Leu Glu Gln Glu Arg Gln Asn Val 
            100                 105                 110         


Glu Gly Gly Pro Glu Gly Leu His Leu Glu Pro Gly Asn Glu Asp Arg 
        115                 120                 125             


Pro Asp Asp Ala Leu Gln Thr Ala Leu Lys Arg Arg Arg Asp Leu Leu 
    130                 135                 140                 


Gln Arg Leu Arg Glu Gln His Leu Leu Asp Glu Leu Ser Arg Ala Gln 
145                 150                 155                 160 


Ala Trp Ser Gly Pro Ser Arg Gly Ala Leu Gly Ser Ala Leu Pro Pro 
                165                 170                 175     


Glu Leu Pro Pro Thr Gly Ile Leu Pro Thr Ala Ser Pro Ser Pro Leu 
            180                 185                 190         


Ala Pro Asp Pro Pro Arg Ile Ile Leu Pro Thr Val Pro Gln Pro Pro 
        195                 200                 205             


Ala Thr Ile Ile Gln Gln Leu Pro Gln Gln Pro Leu Ile Ala Gln Ile 
    210                 215                 220                 


Pro Pro Pro Gln Ala Phe Pro Thr Gln Arg Ser Gly Ser Ile Lys Glu 
225                 230                 235                 240 


Asp Met Val Glu Leu Leu Leu Leu Gln Asn Ala Gln Val His Gln Leu 
                245                 250                 255     


Val Leu Gln Asn Trp Met Leu Lys Ala Leu Pro Pro Ala Leu Gln Asp 
            260                 265                 270         


Pro Pro His Val Pro Pro Arg Val Pro Arg Ala Ala Arg Pro Arg Leu 
        275                 280                 285             


Pro Ala Val His His His His His His His His Ala Val Trp Pro Pro 
    290                 295                 300                 


Gly Ala Ala Thr Val Leu Gln Pro Ala Pro Ser Leu Trp Thr Pro Gly 
305                 310                 315                 320 


Pro Pro 
        


<210>  3980
<211>  2957
<212>  DNA
<213>  Homosapiens

<400>  3980
caaaaagttc gcgctgctgg tcccgcgcgg gcggcccctg ggctttgtgt ccaccaggac     60

agcgggccgg gctccctgca ggcgcgggcg gcgccgaacg gtgctcagca accacccgga    120

cagggccagg ccgttttctc ccgctcaggc attagtcgtt ggctgtgggc cgccgcggga    180

agttgaggcc taccacggag gaggctgctg aggtggatct caggggatcc gcaagggctc    240

cctcaccctt gccgggaccc tgggaacccg aaacaaaatc ctacgccacc agcccgccga    300

atgcgccccc tcggccgggg gtcctgggtc ttcagagaag aactcggccg aatgcggtca    360

gaaagcccgc gaaccgcctg gacctgcagg ccccgccgct tggagctccc gcctttcccg    420

accgagcccg tgtctgctcg tgtgtctcac tgatgtctta ggtctcaaaa aaaaaagaaa    480

agaaaaggtt tttagtagac agaagagaaa tggggccgtg ggttcgtggt cccaggggga    540

aactgacgtc gcatgaggtc gtcgtccctc agcttgagct cagcggaaca taagcttgca    600

gaggtggaaa ccacggaagg tttgggtgtc ttggagctct ctggacaccg aagcccggac    660

acagtcccgg ggtccgcacc gcctgtgacc tgtggcggga ccgccggggt gggcgttttc    720

tcagctggcg cgcgcgtagg tggaacttgg gaaactaact ggagcgaagt ggcaaaaaac    780

caagacaggg ccggtgacct cgcgcaggcc gtccttaact gtggagtatt ccttcagcta    840

acccctttat ttcatgtgtc caagtctggt ttctgggttt ctttgtagtc cctccgggcc    900

tgttcgtgcg ccttcacttg caaaaggttc gtcgtggagg gccgtgtgct tgtttgcagc    960

agtaacgatg cccttcccga gcgtgctgga gtggctcctc gctgacgcaa gctcaccttg   1020

cagcctcctc agcaactgca acttaaacgc gccctcagga agccctggaa tctcgctcag   1080

aatttttttt ctttttttga gacagtctcg ctgcgacgcc caggctatag cgcaatggcg   1140

cgatctcggc tccctgcaac ctccctcagg aagccgtgga agctcgaccg ccagaaactt   1200

ccttctcctg actcaggcca cagtcttctg tgtggctggt ctccaggagg taaggcccgc   1260

cctgcaggca acaccggtgc ttgggctcct gctgagcagt tctttcctgc gagtaacaga   1320

accagggagg gaggtgggct gtggcctccc ctgcccctac agtcgtctcc tgcagctccc   1380

accatgctgg actcatcagc agcagagcaa gtgacccgac tgacgctgaa gctcttggga   1440

cagaaagcct cttagtcatt cctggagcac acagggcctt tgcgtggagc caccgtctct   1500

gtcacggtct ctcttcctca cagaagctgg agcaagaacg gcagaacgtg gaagggggac   1560

ctgagggcct ccacctcgag ccaggaaatg aggaccggcc ggacgatgcc ctgcagactg   1620

ctctgaagag aaggagggac cttctgcaga gactccggga ggccaccctc atgcacataa   1680

ccctggaagg gtcttccagt catggccatc ctgcccggag aggcgcctgt acctggccca   1740

ggctggcctg agcctgatgc tgggggtgcc tctgtggcgt tggggctccc cgtccccgtg   1800

tgcagcagct ctgcatcggc cttgcaggaa caacacctcc tggacgagct ctctcgggcc   1860

caggcctgga gcgggccaag cagaggagcc ctcgggtcag ccctgccccc agagctgccc   1920

cccacgggca tcctacccac tgcctcccca tccccgctgg ccccagaccc gccaaggatc   1980

atcctgccta cggtccccca gcctcctgcc accatcattc agcagctccc tcagcagcca   2040

ctcatagcac agattcctcc tccccaggcc ttccctactc aacggtcagg aagtattaag   2100

gaagacatgg tggagctgct gctgctgcag aacgcacagg tgcaccagtt ggtcctgcag   2160

aactggatgc tcaaggccct gcccccagcc ctgcaggacc cgccacatgt gcccccgagg   2220

gtcccacgag ctgccaggcc aaggctgcct gccgtgcacc accaccacca ccaccaccat   2280

gctgtgtggc cacctggggc tgccactgtc ctccagcccg cccccagcct gtggacgcct   2340

ggcccaccct gagtggcggc gccggcccac ctgggagcct cagatccccc tcttccatca   2400

cggaggtaaa gttgaggccg tggacgccac cagcctgatg aaataaagat ttcatccaga   2460

aagagtttaa gaaaatctca gctcaggagc cagaacagaa aagatcaata gctttagcca   2520

catggaagtg tgaacatcct gatggggaaa ataccacaaa gtctaattta ataactaggg   2580

acacctgtgt gccacagctg tggcacagac tcccactaaa gaagtagggg tgcatggctc   2640

atgcctgtaa tcccagcact ttaagaggct gaggcaggag gatcacttga gctcaggaat   2700

tcgagaccag cctgggtcac atagcaagac cccgtctcta caaaaaataa atttaaaaaa   2760

ctagccaggt gtggtgatat gcgcctgtta tctcagcagc tctgggggct gaggtgggag   2820

gattgcttga gcccaggagt tagaagctgc agtgagctct gatggaacca ctgcactata   2880

gcctggacca cagagcaggc ccctgtctca aaaaataaaa taaaaaagtg aaagaagaaa   2940

aaaaaaaaaa aaaaaaa                                                  2957


<210>  3981
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  3981

Met Ala Arg Ser Arg Leu Pro Ala Thr Ser Leu Arg Lys Pro Trp Lys 
1               5                   10                  15      


Leu Asp Arg Gln Lys Leu Pro Ser Pro Asp Ser Gly His Ser Leu Leu 
            20                  25                  30          


Cys Gly Trp Ser Pro Gly Gly Lys Ala Arg Pro Ala Gly Asn Thr Gly 
        35                  40                  45              


Ala Trp Ala Pro Ala Glu Gln Phe Phe Pro Ala Ser Asn Arg Thr Arg 
    50                  55                  60                  


Glu Gly Gly Gly Leu Trp Pro Pro Leu Pro Leu Gln Ser Ser Pro Ala 
65                  70                  75                  80  


Ala Pro Thr Met Leu Asp Ser Ser Ala Ala Glu Gln Val Thr Arg Leu 
                85                  90                  95      


Thr Leu Lys Leu Leu Gly Gln Lys Ala Ser 
            100                 105     


<210>  3982
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  3982
aagcgcgggg gagggagtgt aaatagagcg aaggctgctc tgtgtcagcc ccgtcaccgc     60

cgggcggccc gcgcggagtc tgagggagat ggaagttgag caagagcagc ggcgcagaaa    120

ggtggaggcc gggaggacga agcttgctca cttccgacag agaaaaacaa aaggtgacag    180

ttcgcattcg gagaaaaaga cggcgaagag gaagggctcg gctgtcgatg cgtctgtcca    240

ggaggagagt ccggtaacca aggaggacag cgcactctgt ggaggagggg acatttgcaa    300

aagcacatca tgtgacgaca cccctgatgg ggcaggaggg gcctttgcag ctcagccgga    360

ggactgtgat ggagagaaga gagaggactt ggaacagctg cagcagaagc aagtcaatga    420

ccatcctcca gagcagtgtg ggatgttcac agtcagtgac cacccaccag aacagcatgg    480

gatgttcaca gtcggtgacc acccaccaga acagcgtggg atgttcacag tcagtgacca    540

cccaccagaa cagcatggga tgttcacagt cagtgaccac ccaccagaac agcgtgggat    600

gttcacaatc agtgaccacc aaccggaaca gcgtgggatg ttcacagtca gtgaccacac    660

accagaacag cgtgggatct tcacaatcag tgaccaccca gcagaacagc gtgggatgtt    720

cacaaaggag tgtgaacaag aatgtgaact tgccattact gacctggaga gcggccgtga    780

agatgaggct ggcctgcatc agagtcaggc cgtgcatggc cttgagctgg aggcgctgcg    840

cctgagtctg agcaacatgc acacggcgca gctggagctg acacaggcca acctccagaa    900

ggagaaggag acggcattga cggagctgcg ggagatgctc aacagccggc gtgcccagga    960

gctggccctg ctacagagca ggcagcagca cgagctggag ctcctcaggg agcagcacgc   1020

acgggagaag gaggaggtgg tgctcaggtg tggacaggaa gcagctgagc tgaaggagaa   1080

gttacaatca gaaatggaga aaaacgccca gatagtaaag accctgaagg aagattggga   1140

atctgaaaaa gatttatgtt tagaaaatct acgcaaagaa ctgtctgcaa agcatcaatc   1200

agaaatggag gatttacaaa accagtttca gaaagaattg gcagaacaga gagctgagtt   1260

ggagaagatt tttcaagaca aaaaccaggc tgaacgggcc cttaggaacc tggagagtca   1320

tcatcaagca gccattgaga agttacgtga agacctgcag tccgagcacg gccggtgttt   1380

agaagacttg gagttcaagt tcaaagagag cgagaaagaa aaacagctgg agttagagaa   1440

tcttcaagca tcatatgaag acctgaaggc acaatcacaa gaagagatca ggcgcttgtg   1500

gtcccagctt gattctgcca ggaccagtag acaggaattg agtgagctac atgagcaact   1560

cctggcgcgc acctctcgtg tggaagattt agaacagctg aagcagcgag aaaaaaccca   1620

gcatgagtcc gaactggagc aactgaggat ttattttgaa aagaagttaa gggatgctga   1680

gaaaacttac caagaagacc taaccctgtt acagcagagg ctgcaggggg cgagggaaga   1740

tgctcttctg gactctgtgg aagttgggtt gtcctgtgtg ggtttagaag agaaacctga   1800

gaaaggaaga aaagatcacg ttgatgaact cgagcctgag cgacataagg agagcctgcc   1860

acgcttccag gcggagttag aagaaagcca caggcaccag ctggaagcgc tggagtctcc   1920

cctctgcatc cagcacgagg ggcatgtctc agacagatgc tgcgtagaga cttcagcatt   1980

gggacacgag tggcgtctgg aaccctctga agggcacagc caagagcttc cctgggtgca   2040

tctccagggt gtgcaggacg gggacttgga ggccgacaca gagcgggcag ccagagtctt   2100

gggtctggaa actgagcaca aggtgcaact ttcgcttctt cagactgagc tcaaagaaga   2160

aattgaactc ctaaaaatag aaaatagaaa tttgtatggg aagttgcagc atgaaactcg   2220

tctgaaggac gatttggaga aggtaaaaca caatctaatt gaagaccacc agaaggaact   2280

aaataatgct aagcaaaaga ctgagctgat gaaacaggaa ttccaaagaa aagaaacgga   2340

ctggaaagtt atgaaggagg agctacagcg ggaagctgag gagaagttaa cattgatgct   2400

acttgaactg agagaaaagg ctgaatccga gaaacagacc atcataaaca agtttgagct   2460

tcgagaagct gaaatgaggc agcttcagga ccaacaggca gcccagatcc tggatctgga   2520

gaggtccttg acggagcagc agggccgcct gcagcagctg gaacaggacc tcacttcaga   2580

cgacgccctg cattgcagcc agtgtgggcg ggagccgccc acagcccagg acggggagct   2640

tgctgcgctc cacgtgaagg aagactgcgc cctgcagctg atgctggccc ggagcaggtt   2700

tttagaggaa cgtaaagaga tcaccgagaa attcagtgcg gaacaagatg ccttcctgca   2760

ggaggcccag gagcagcatg cccgtgagct gcagctcctc caggagagac accagcagca   2820

gctcctgtca gtgacggcgg agctcgaggc cagacaccag gccgcgttgg gcgagctgac   2880

agcctcctta gagagcaagc agggggctct gctggctgca cgtgtggccg aactgcagac   2940

aaaacacgct gccgacctcg gcgctctgga gaccagacat ctgtccagcc ttgattcttt   3000

ggaatcctgt tacctctctg aatttcagac catccgtgag gagcacaggc aggccctaga   3060

gctcttacga gcagactttg aggaacaact gtggaaaaag gactctcttc accaaacgat   3120

tttgactcaa gagttggaga aactgaagcg gaaacacgaa ggggagctac agtctgtgcg   3180

ggaccacctg cgaaccgaag tgagcacaga gctcgccgga accgtggctc acgagctgca   3240

gggagtgcac cagggtgaat ttggaagtga aaagaaaact gctttgcatg aaaaagagga   3300

gacacttcgg cttcagagtg cacaggcaca gccttttcac caagaggaga aagagtcttt   3360

gtctctgcag cttcaaaaga agaatcacca agtccagcag ctgaaagacc aggttttatc   3420

cttaagtcac gagatagaag agtgccgctc cgagttggag gtgctgcagc agaggcggga   3480

gcgggagaac cgggaaggcg caaacctcct ctccatgctc aaggccgacg tcaacctgtc   3540

ccacagcgaa agaggggccc tccaggacgc cctgcgcagg ctgctgggtt tgtttggaga   3600

gacgctgagg gcagccgtca ccctgaggag ccggatcggg gagcgcgtgg ggctctgcct   3660

ggatgacgcg ggcgcaggcc tggccctgtc gacagctccg gcgctggagg agacatggtc   3720

tgatgtggcc ctcccggagt tggacagaac tttgtctgaa tgtgcagaga tgtcttccgt   3780

ggctgaaatt agcagccaca tgcgtgaaag ctttctcatg agcccagaaa gtgtgcggga   3840

gtgtgagcag cccatccgga gggtcttcca gagcctcagc ctggccgtgg acggcctcat   3900

ggagatggcc ctggactcca gcaggcagct ggaagaagca cgccaaattc attctcgttt   3960

tgaaaaagaa tttagtttta agaatgagga gacagcacag gttgtcagga agcaccagga   4020

gctgctggag tgtttgaagg aggagagcgc agcaaaggca gagctggcgc tggagctgca   4080

caagactcag ggtacccttg agggattcaa ggtggagaca gcagatctga aggaggtgct   4140

ggccgggaag gaggattccg agcaccgtct ggtgctggag ctggagagcc tgagacggca   4200

gctgcagcag gcggcccagg agcaggcggc gctgagggag gagtgcaccc gtctgtggag   4260

tcggggggag gccacagcca cggacgccga ggccagagaa gctgctctcc ggaaggaagt   4320

ggaggatctg accaaagaac agtcggagac caggaagcag gctgagaagg accgctcagc   4380

cctgctctcc cagatgaaga ttttggagtc tgagttagaa gaacagctgt ctcagcatcg   4440

cgggtgtgcc aagcaggcgg aggccgtcac tgccctggaa cagcaggtgg catctctgga   4500

caagcatttg cgcaaccagc ggcaattcat ggatgagcag gcagccgagc gggagcacga   4560

gcgcgaggag ttccagcagg agattcagag gctggagggg cagctccgcc aggcggccaa   4620

gccgcagccc tggggccctc gcgacagcca gcaggcgccg ctggatggag aggttgagtt   4680

gttacaacaa aagttgagag aaaagttgga tgaatttaat gaattggcta tacagaaaga   4740

gtcggcagat agacaagtgt taatgcagga agaagaaatt aaacgtctgg aggagatgaa   4800

catcaacatc aggaaaaaag tggcccagct ccaggaagaa gtggaaaaac agaaaaacat   4860

cgtgaaaggg ctggaacagg ataaagaggt gttaaagaaa cagcagatga gtagcttgct   4920

tctggcgtcc acgttgcagt ctacactaga tgcaggcaga tgtcccgagc ctccttcggg   4980

cagccctcct gagggtccag aaatacagtt agaggtgaca cagagagcac tcctgcggcg   5040

cgagagcgag gttttggact taaaagaaca gctagaaaag atgaaaggtg acttagaaag   5100

taaaaatgaa gaaatactac atctgaactt aaaattggac atgcagaaca gccagactgc   5160

tgtcagcctc agagaacttg aggaagagaa cacgagcttg aaggtcatat ataccagaag   5220

ttctgagatt gaagagctga aagccactat tgaaaatctg caagagaatc agaaacgatt   5280

acaaaaggag aaagcagagg aaattgaaca actccatgaa gtcattgaga agctgcagca   5340

cgagctgtcc ctcatggggc ctgtggtgca cgaagtcagc gacagtcagg ctggcagtct   5400

gcagagcgag ctgctctgct cccaggccgg gggccctcgt gggcaggccc tacagggcga   5460

gctcgaggct gcgctggaag ccaaggaggc cctgagccgg ctgctggctg accaggagcg   5520

caggcacagc caggccctgg aggccctgca gcagcgcctc cagggcgcag aggaggctgc   5580

ggagctacag ctggctgagc tggagcgcaa tgtagccctc agggaggctg aggtcgaaga   5640

catggcctcc cggatccagg agttcgaagc ggccctgaaa gcaaaggaag cgacgattgc   5700

cgagagaaat ttagaaatcg acgctctgaa ccagcggaag gcggcccact ctgccgagct   5760

ggaggccgtc ctgttggcct tggcccgcat ccgccgcgcc ctggagcagc agcccctggc   5820

agccggggcg gcgcctcccg agctgcagtg gctccgagcg cagtgtgccc gcctcagccg   5880

ccagctgcag gtgctgcacc agcggttcct gaggtgccag gtggagctgg acaggcggca   5940

ggcccgcaga gccacagctc acacacgggt gcccggggcc cacccacagc ctcgcatgga   6000

tggtggcgcc aaggcccagg tcaccggcga cgtggaggcc tcccatgatg ctgctttgga   6060

gccggttgtc cctgacccac agggtgatct gcagcctgtc ctggtgacgt tgaaggatgc   6120

acctctctgc aagcaagaag gcgtgatgtc agtgctcacc gtctgccaga ggcagctgca   6180

gtcggagctg ctcttggtga aaaatgaaat gcgcctgagt ctggaggacg gcggcaaggg   6240

taaagaaaaa gtactggaag attgtcagct gccgaaggtc gatctcgtag ctcaggtgaa   6300

acagcttcag gaaaaactga accgtttgct gtattccatg accttccaga atgtggatgc   6360

tgccgacacc aaatctctgt ggcccatggc ctcagcacac ctgttggaga gcagctggag   6420

tgatgattcc tgtgacggag aagagcctga catatcaccc cacatagaca catgtgatgc   6480

caatacagcc acggggggtg taactgatgt tatcaaaaat caggccatag acgcgtgtga   6540

tgccaataca accccagggg gtgtaactga tgttatcaaa aattgggatt ccttgatacc   6600

agatgaaatg ccagattctc ccattcaaga aaaatcagaa tgtcaggaca tgtctctttc   6660

ttcaccgacc agcgtacttg gtggctcccg ccaccagagc cacactgcag aggctgggcc   6720

ccggaagagc ccggtcggga tgctggacct gtcttcctgg agctcccctg aggtcctcag   6780

gaaggactgg accctggagc cctggcccag cctccccgtg acaccccact caggagccct   6840

gagcctgtgc agtgccgaca catccctggg ggacagggcg gacacctcgc tgccacagac   6900

ccaggggccg gggctgcttt gttccccagg cgtgtctgca gcagcgctgg cactgcagtg   6960

ggccgagtct ccgccggctg acgaccacca tgtgcagagg acggctgtgg agaaagatgt   7020

cgaagatttt atcacaacat cctttgattc tcaagaaaca ttaagttcac ctcctcctgg   7080

attagaagga aaagctgata gaagtgagaa aagtgacggc tcgggttttg gagcaagact   7140

gagcccgggg tcaggaggcc ctgaggctca aactgctggt cctgtgaccc ctgcttccat   7200

ctctggaagg tttcagccgc tgccggaagc catgaaggag aaggaagtgc gtccgaagca   7260

cgtgaaggct ttactgcaga tggtgcgtga cgagagccac cagatcctgg cgctgtcaga   7320

aggccttgca cccccaagcg gcgagccaca cccaccccgg aaggaagacg agatacagga   7380

catctcgctc catgggggaa agacgcagga agtgcccacc gcgtgccccg attggagagg   7440

ggaccttctg caggttgtgc aagaggcctt tgaaaaagag caggagatgc agggggttga   7500

gctgcagccc cgactcagtg gctcagatct ggggggtcac agctccctgc tcgaaaggct   7560

ggagaagatc atccgtgagc agggagacct gcaggaaaag tccctggagc atcttcgctt   7620

gccggaccgg agcagcctgc tgtccgagat ccaggcgctg cgtgcccagc tgcgcatgac   7680

gcacctgcag aaccaggaga agctgcagca cttgcgcacg gcgctgacaa gcgcagaggc   7740

gcgcgggagc cagcaggagc accagctgcg caggcaggtt gaactgctgg cttataaagt   7800

agagcaggag aagtgcattg ctggtgactt gcagaagacg ctgagtgaag agcaagagaa   7860

ggcaaacagc gtgcagaagc tcctggcggc ggagcagact gtagtgcgag atttgaagtc   7920

cgacctctgt gagagcaggc agaagagcga acagctgtcc cggtccctct gcgaggtgca   7980

gcaggaggtc ctccagctga gatccatgct gagcagtaag gagaacgagc tgaaggccgc   8040

gcttcaggag ctggagagtg agcaggggaa ggggcgtgcc ctgcagagcc agctggagga   8100

ggagcagctg cggcacctgc agagggagag ccagagtgcc aaggccctgg aggagctgcg   8160

ggcgtctttg gagacacagc gtgctcagag ca                                 8192


<210>  3983
<211>  3336
<212>  PRT
<213>  Homosapiens

<400>  3983

Met Glu Val Glu Gln Glu Gln Arg Arg Arg Lys Val Glu Ala Gly Arg 
1               5                   10                  15      


Thr Lys Leu Ala His Phe Arg Gln Arg Lys Thr Lys Gly Asp Ser Ser 
            20                  25                  30          


His Ser Glu Lys Lys Thr Ala Lys Arg Lys Gly Ser Ala Val Asp Ala 
        35                  40                  45              


Ser Val Gln Glu Glu Ser Pro Val Thr Lys Glu Asp Ser Ala Leu Cys 
    50                  55                  60                  


Gly Gly Gly Asp Ile Cys Lys Ser Thr Ser Cys Asp Asp Thr Pro Asp 
65                  70                  75                  80  


Gly Ala Gly Gly Ala Phe Ala Ala Gln Pro Glu Asp Cys Asp Gly Glu 
                85                  90                  95      


Lys Arg Glu Asp Leu Glu Gln Leu Gln Gln Lys Gln Val Asn Asp His 
            100                 105                 110         


Pro Pro Glu Gln Cys Gly Met Phe Thr Val Ser Asp His Pro Pro Glu 
        115                 120                 125             


Gln His Gly Met Phe Thr Val Gly Asp His Pro Pro Glu Gln Arg Gly 
    130                 135                 140                 


Met Phe Thr Val Ser Asp His Pro Pro Glu Gln His Gly Met Phe Thr 
145                 150                 155                 160 


Val Ser Asp His Pro Pro Glu Gln Arg Gly Met Phe Thr Ile Ser Asp 
                165                 170                 175     


His Gln Pro Glu Gln Arg Gly Met Phe Thr Val Ser Asp His Thr Pro 
            180                 185                 190         


Glu Gln Arg Gly Ile Phe Thr Ile Ser Asp His Pro Ala Glu Gln Arg 
        195                 200                 205             


Gly Met Phe Thr Lys Glu Cys Glu Gln Glu Cys Glu Leu Ala Ile Thr 
    210                 215                 220                 


Asp Leu Glu Ser Gly Arg Glu Asp Glu Ala Gly Leu His Gln Ser Gln 
225                 230                 235                 240 


Ala Val His Gly Leu Glu Leu Glu Ala Leu Arg Leu Ser Leu Ser Asn 
                245                 250                 255     


Met His Thr Ala Gln Leu Glu Leu Thr Gln Ala Asn Leu Gln Lys Glu 
            260                 265                 270         


Lys Glu Thr Ala Leu Thr Glu Leu Arg Glu Met Leu Asn Ser Arg Arg 
        275                 280                 285             


Ala Gln Glu Leu Ala Leu Leu Gln Ser Arg Gln Gln His Glu Leu Glu 
    290                 295                 300                 


Leu Leu Arg Glu Gln His Ala Arg Glu Lys Glu Glu Val Val Leu Arg 
305                 310                 315                 320 


Cys Gly Gln Glu Ala Ala Glu Leu Lys Glu Lys Leu Gln Ser Glu Met 
                325                 330                 335     


Glu Lys Asn Ala Gln Ile Val Lys Thr Leu Lys Glu Asp Trp Glu Ser 
            340                 345                 350         


Glu Lys Asp Leu Cys Leu Glu Asn Leu Arg Lys Glu Leu Ser Ala Lys 
        355                 360                 365             


His Gln Ser Glu Met Glu Asp Leu Gln Asn Gln Phe Gln Lys Glu Leu 
    370                 375                 380                 


Ala Glu Gln Arg Ala Glu Leu Glu Lys Ile Phe Gln Asp Lys Asn Gln 
385                 390                 395                 400 


Ala Glu Arg Ala Leu Arg Asn Leu Glu Ser His His Gln Ala Ala Ile 
                405                 410                 415     


Glu Lys Leu Arg Glu Asp Leu Gln Ser Glu His Gly Arg Cys Leu Glu 
            420                 425                 430         


Asp Leu Glu Phe Lys Phe Lys Glu Ser Glu Lys Glu Lys Gln Leu Glu 
        435                 440                 445             


Leu Glu Asn Leu Gln Ala Ser Tyr Glu Asp Leu Lys Ala Gln Ser Gln 
    450                 455                 460                 


Glu Glu Ile Arg Arg Leu Trp Ser Gln Leu Asp Ser Ala Arg Thr Ser 
465                 470                 475                 480 


Arg Gln Glu Leu Ser Glu Leu His Glu Gln Leu Leu Ala Arg Thr Ser 
                485                 490                 495     


Arg Val Glu Asp Leu Glu Gln Leu Lys Gln Arg Glu Lys Thr Gln His 
            500                 505                 510         


Glu Ser Glu Leu Glu Gln Leu Arg Ile Tyr Phe Glu Lys Lys Leu Arg 
        515                 520                 525             


Asp Ala Glu Lys Thr Tyr Gln Glu Asp Leu Thr Leu Leu Gln Gln Arg 
    530                 535                 540                 


Leu Gln Gly Ala Arg Glu Asp Ala Leu Leu Asp Ser Val Glu Val Gly 
545                 550                 555                 560 


Leu Ser Cys Val Gly Leu Glu Glu Lys Pro Glu Lys Gly Arg Lys Asp 
                565                 570                 575     


His Val Asp Glu Leu Glu Pro Glu Arg His Lys Glu Ser Leu Pro Arg 
            580                 585                 590         


Phe Gln Ala Glu Leu Glu Glu Ser His Arg His Gln Leu Glu Ala Leu 
        595                 600                 605             


Glu Ser Pro Leu Cys Ile Gln His Glu Gly His Val Ser Asp Arg Cys 
    610                 615                 620                 


Cys Val Glu Thr Ser Ala Leu Gly His Glu Trp Arg Leu Glu Pro Ser 
625                 630                 635                 640 


Glu Gly His Ser Gln Glu Leu Pro Trp Val His Leu Gln Gly Val Gln 
                645                 650                 655     


Asp Gly Asp Leu Glu Ala Asp Thr Glu Arg Ala Ala Arg Val Leu Gly 
            660                 665                 670         


Leu Glu Thr Glu His Lys Val Gln Leu Ser Leu Leu Gln Thr Glu Leu 
        675                 680                 685             


Lys Glu Glu Ile Glu Leu Leu Lys Ile Glu Asn Arg Asn Leu Tyr Gly 
    690                 695                 700                 


Lys Leu Gln His Glu Thr Arg Leu Lys Asp Asp Leu Glu Lys Val Lys 
705                 710                 715                 720 


His Asn Leu Ile Glu Asp His Gln Lys Glu Leu Asn Asn Ala Lys Gln 
                725                 730                 735     


Lys Thr Glu Leu Met Lys Gln Glu Phe Gln Arg Lys Glu Thr Asp Trp 
            740                 745                 750         


Lys Val Met Lys Glu Glu Leu Gln Arg Glu Ala Glu Glu Lys Leu Thr 
        755                 760                 765             


Leu Met Leu Leu Glu Leu Arg Glu Lys Ala Glu Ser Glu Lys Gln Thr 
    770                 775                 780                 


Ile Ile Asn Lys Phe Glu Leu Arg Glu Ala Glu Met Arg Gln Leu Gln 
785                 790                 795                 800 


Asp Gln Gln Ala Ala Gln Ile Leu Asp Leu Glu Arg Ser Leu Thr Glu 
                805                 810                 815     


Gln Gln Gly Arg Leu Gln Gln Leu Glu Gln Asp Leu Thr Ser Asp Asp 
            820                 825                 830         


Ala Leu His Cys Ser Gln Cys Gly Arg Glu Pro Pro Thr Ala Gln Asp 
        835                 840                 845             


Gly Glu Leu Ala Ala Leu His Val Lys Glu Asp Cys Ala Leu Gln Leu 
    850                 855                 860                 


Met Leu Ala Arg Ser Arg Phe Leu Glu Glu Arg Lys Glu Ile Thr Glu 
865                 870                 875                 880 


Lys Phe Ser Ala Glu Gln Asp Ala Phe Leu Gln Glu Ala Gln Glu Gln 
                885                 890                 895     


His Ala Arg Glu Leu Gln Leu Leu Gln Glu Arg His Gln Gln Gln Leu 
            900                 905                 910         


Leu Ser Val Thr Ala Glu Leu Glu Ala Arg His Gln Ala Ala Leu Gly 
        915                 920                 925             


Glu Leu Thr Ala Ser Leu Glu Ser Lys Gln Gly Ala Leu Leu Ala Ala 
    930                 935                 940                 


Arg Val Ala Glu Leu Gln Thr Lys His Ala Ala Asp Leu Gly Ala Leu 
945                 950                 955                 960 


Glu Thr Arg His Leu Ser Ser Leu Asp Ser Leu Glu Ser Cys Tyr Leu 
                965                 970                 975     


Ser Glu Phe Gln Thr Ile Arg Glu Glu His Arg Gln Ala Leu Glu Leu 
            980                 985                 990         


Leu Arg Ala Asp Phe Glu Glu Gln  Leu Trp Lys Lys Asp  Ser Leu His 
        995                 1000                 1005             


Gln Thr  Ile Leu Thr Gln Glu  Leu Glu Lys Leu Lys  Arg Lys His 
    1010                 1015                 1020             


Glu Gly  Glu Leu Gln Ser Val  Arg Asp His Leu Arg  Thr Glu Val 
    1025                 1030                 1035             


Ser Thr  Glu Leu Ala Gly Thr  Val Ala His Glu Leu  Gln Gly Val 
    1040                 1045                 1050             


His Gln  Gly Glu Phe Gly Ser  Glu Lys Lys Thr Ala  Leu His Glu 
    1055                 1060                 1065             


Lys Glu  Glu Thr Leu Arg Leu  Gln Ser Ala Gln Ala  Gln Pro Phe 
    1070                 1075                 1080             


His Gln  Glu Glu Lys Glu Ser  Leu Ser Leu Gln Leu  Gln Lys Lys 
    1085                 1090                 1095             


Asn His  Gln Val Gln Gln Leu  Lys Asp Gln Val Leu  Ser Leu Ser 
    1100                 1105                 1110             


His Glu  Ile Glu Glu Cys Arg  Ser Glu Leu Glu Val  Leu Gln Gln 
    1115                 1120                 1125             


Arg Arg  Glu Arg Glu Asn Arg  Glu Gly Ala Asn Leu  Leu Ser Met 
    1130                 1135                 1140             


Leu Lys  Ala Asp Val Asn Leu  Ser His Ser Glu Arg  Gly Ala Leu 
    1145                 1150                 1155             


Gln Asp  Ala Leu Arg Arg Leu  Leu Gly Leu Phe Gly  Glu Thr Leu 
    1160                 1165                 1170             


Arg Ala  Ala Val Thr Leu Arg  Ser Arg Ile Gly Glu  Arg Val Gly 
    1175                 1180                 1185             


Leu Cys  Leu Asp Asp Ala Gly  Ala Gly Leu Ala Leu  Ser Thr Ala 
    1190                 1195                 1200             


Pro Ala  Leu Glu Glu Thr Trp  Ser Asp Val Ala Leu  Pro Glu Leu 
    1205                 1210                 1215             


Asp Arg  Thr Leu Ser Glu Cys  Ala Glu Met Ser Ser  Val Ala Glu 
    1220                 1225                 1230             


Ile Ser  Ser His Met Arg Glu  Ser Phe Leu Met Ser  Pro Glu Ser 
    1235                 1240                 1245             


Val Arg  Glu Cys Glu Gln Pro  Ile Arg Arg Val Phe  Gln Ser Leu 
    1250                 1255                 1260             


Ser Leu  Ala Val Asp Gly Leu  Met Glu Met Ala Leu  Asp Ser Ser 
    1265                 1270                 1275             


Arg Gln  Leu Glu Glu Ala Arg  Gln Ile His Ser Arg  Phe Glu Lys 
    1280                 1285                 1290             


Glu Phe  Ser Phe Lys Asn Glu  Glu Thr Ala Gln Val  Val Arg Lys 
    1295                 1300                 1305             


His Gln  Glu Leu Leu Glu Cys  Leu Lys Glu Glu Ser  Ala Ala Lys 
    1310                 1315                 1320             


Ala Glu  Leu Ala Leu Glu Leu  His Lys Thr Gln Gly  Thr Leu Glu 
    1325                 1330                 1335             


Gly Phe  Lys Val Glu Thr Ala  Asp Leu Lys Glu Val  Leu Ala Gly 
    1340                 1345                 1350             


Lys Glu  Asp Ser Glu His Arg  Leu Val Leu Glu Leu  Glu Ser Leu 
    1355                 1360                 1365             


Arg Arg  Gln Leu Gln Gln Ala  Ala Gln Glu Gln Ala  Ala Leu Arg 
    1370                 1375                 1380             


Glu Glu  Cys Thr Arg Leu Trp  Ser Arg Gly Glu Ala  Thr Ala Thr 
    1385                 1390                 1395             


Asp Ala  Glu Ala Arg Glu Ala  Ala Leu Arg Lys Glu  Val Glu Asp 
    1400                 1405                 1410             


Leu Thr  Lys Glu Gln Ser Glu  Thr Arg Lys Gln Ala  Glu Lys Asp 
    1415                 1420                 1425             


Arg Ser  Ala Leu Leu Ser Gln  Met Lys Ile Leu Glu  Ser Glu Leu 
    1430                 1435                 1440             


Glu Glu  Gln Leu Ser Gln His  Arg Gly Cys Ala Lys  Gln Ala Glu 
    1445                 1450                 1455             


Ala Val  Thr Ala Leu Glu Gln  Gln Val Ala Ser Leu  Asp Lys His 
    1460                 1465                 1470             


Leu Arg  Asn Gln Arg Gln Phe  Met Asp Glu Gln Ala  Ala Glu Arg 
    1475                 1480                 1485             


Glu His  Glu Arg Glu Glu Phe  Gln Gln Glu Ile Gln  Arg Leu Glu 
    1490                 1495                 1500             


Gly Gln  Leu Arg Gln Ala Ala  Lys Pro Gln Pro Trp  Gly Pro Arg 
    1505                 1510                 1515             


Asp Ser  Gln Gln Ala Pro Leu  Asp Gly Glu Val Glu  Leu Leu Gln 
    1520                 1525                 1530             


Gln Lys  Leu Arg Glu Lys Leu  Asp Glu Phe Asn Glu  Leu Ala Ile 
    1535                 1540                 1545             


Gln Lys  Glu Ser Ala Asp Arg  Gln Val Leu Met Gln  Glu Glu Glu 
    1550                 1555                 1560             


Ile Lys  Arg Leu Glu Glu Met  Asn Ile Asn Ile Arg  Lys Lys Val 
    1565                 1570                 1575             


Ala Gln  Leu Gln Glu Glu Val  Glu Lys Gln Lys Asn  Ile Val Lys 
    1580                 1585                 1590             


Gly Leu  Glu Gln Asp Lys Glu  Val Leu Lys Lys Gln  Gln Met Ser 
    1595                 1600                 1605             


Ser Leu  Leu Leu Ala Ser Thr  Leu Gln Ser Thr Leu  Asp Ala Gly 
    1610                 1615                 1620             


Arg Cys  Pro Glu Pro Pro Ser  Gly Ser Pro Pro Glu  Gly Pro Glu 
    1625                 1630                 1635             


Ile Gln  Leu Glu Val Thr Gln  Arg Ala Leu Leu Arg  Arg Glu Ser 
    1640                 1645                 1650             


Glu Val  Leu Asp Leu Lys Glu  Gln Leu Glu Lys Met  Lys Gly Asp 
    1655                 1660                 1665             


Leu Glu  Ser Lys Asn Glu Glu  Ile Leu His Leu Asn  Leu Lys Leu 
    1670                 1675                 1680             


Asp Met  Gln Asn Ser Gln Thr  Ala Val Ser Leu Arg  Glu Leu Glu 
    1685                 1690                 1695             


Glu Glu  Asn Thr Ser Leu Lys  Val Ile Tyr Thr Arg  Ser Ser Glu 
    1700                 1705                 1710             


Ile Glu  Glu Leu Lys Ala Thr  Ile Glu Asn Leu Gln  Glu Asn Gln 
    1715                 1720                 1725             


Lys Arg  Leu Gln Lys Glu Lys  Ala Glu Glu Ile Glu  Gln Leu His 
    1730                 1735                 1740             


Glu Val  Ile Glu Lys Leu Gln  His Glu Leu Ser Leu  Met Gly Pro 
    1745                 1750                 1755             


Val Val  His Glu Val Ser Asp  Ser Gln Ala Gly Ser  Leu Gln Ser 
    1760                 1765                 1770             


Glu Leu  Leu Cys Ser Gln Ala  Gly Gly Pro Arg Gly  Gln Ala Leu 
    1775                 1780                 1785             


Gln Gly  Glu Leu Glu Ala Ala  Leu Glu Ala Lys Glu  Ala Leu Ser 
    1790                 1795                 1800             


Arg Leu  Leu Ala Asp Gln Glu  Arg Arg His Ser Gln  Ala Leu Glu 
    1805                 1810                 1815             


Ala Leu  Gln Gln Arg Leu Gln  Gly Ala Glu Glu Ala  Ala Glu Leu 
    1820                 1825                 1830             


Gln Leu  Ala Glu Leu Glu Arg  Asn Val Ala Leu Arg  Glu Ala Glu 
    1835                 1840                 1845             


Val Glu  Asp Met Ala Ser Arg  Ile Gln Glu Phe Glu  Ala Ala Leu 
    1850                 1855                 1860             


Lys Ala  Lys Glu Ala Thr Ile  Ala Glu Arg Asn Leu  Glu Ile Asp 
    1865                 1870                 1875             


Ala Leu  Asn Gln Arg Lys Ala  Ala His Ser Ala Glu  Leu Glu Ala 
    1880                 1885                 1890             


Val Leu  Leu Ala Leu Ala Arg  Ile Arg Arg Ala Leu  Glu Gln Gln 
    1895                 1900                 1905             


Pro Leu  Ala Ala Gly Ala Ala  Pro Pro Glu Leu Gln  Trp Leu Arg 
    1910                 1915                 1920             


Ala Gln  Cys Ala Arg Leu Ser  Arg Gln Leu Gln Val  Leu His Gln 
    1925                 1930                 1935             


Arg Phe  Leu Arg Cys Gln Val  Glu Leu Asp Arg Arg  Gln Ala Arg 
    1940                 1945                 1950             


Arg Ala  Thr Ala His Thr Arg  Val Pro Gly Ala His  Pro Gln Pro 
    1955                 1960                 1965             


Arg Met  Asp Gly Gly Ala Lys  Ala Gln Val Thr Gly  Asp Val Glu 
    1970                 1975                 1980             


Ala Ser  His Asp Ala Ala Leu  Glu Pro Val Val Pro  Asp Pro Gln 
    1985                 1990                 1995             


Gly Asp  Leu Gln Pro Val Leu  Val Thr Leu Lys Asp  Ala Pro Leu 
    2000                 2005                 2010             


Cys Lys  Gln Glu Gly Val Met  Ser Val Leu Thr Val  Cys Gln Arg 
    2015                 2020                 2025             


Gln Leu  Gln Ser Glu Leu Leu  Leu Val Lys Asn Glu  Met Arg Leu 
    2030                 2035                 2040             


Ser Leu  Glu Asp Gly Gly Lys  Gly Lys Glu Lys Val  Leu Glu Asp 
    2045                 2050                 2055             


Cys Gln  Leu Pro Lys Val Asp  Leu Val Ala Gln Val  Lys Gln Leu 
    2060                 2065                 2070             


Gln Glu  Lys Leu Asn Arg Leu  Leu Tyr Ser Met Thr  Phe Gln Asn 
    2075                 2080                 2085             


Val Asp  Ala Ala Asp Thr Lys  Ser Leu Trp Pro Met  Ala Ser Ala 
    2090                 2095                 2100             


His Leu  Leu Glu Ser Ser Trp  Ser Asp Asp Ser Cys  Asp Gly Glu 
    2105                 2110                 2115             


Glu Pro  Asp Ile Ser Pro His  Ile Asp Thr Cys Asp  Ala Asn Thr 
    2120                 2125                 2130             


Ala Thr  Gly Gly Val Thr Asp  Val Ile Lys Asn Gln  Ala Ile Asp 
    2135                 2140                 2145             


Ala Cys  Asp Ala Asn Thr Thr  Pro Gly Gly Val Thr  Asp Val Ile 
    2150                 2155                 2160             


Lys Asn  Trp Asp Ser Leu Ile  Pro Asp Glu Met Pro  Asp Ser Pro 
    2165                 2170                 2175             


Ile Gln  Glu Lys Ser Glu Cys  Gln Asp Met Ser Leu  Ser Ser Pro 
    2180                 2185                 2190             


Thr Ser  Val Leu Gly Gly Ser  Arg His Gln Ser His  Thr Ala Glu 
    2195                 2200                 2205             


Ala Gly  Pro Arg Lys Ser Pro  Val Gly Met Leu Asp  Leu Ser Ser 
    2210                 2215                 2220             


Trp Ser  Ser Pro Glu Val Leu  Arg Lys Asp Trp Thr  Leu Glu Pro 
    2225                 2230                 2235             


Trp Pro  Ser Leu Pro Val Thr  Pro His Ser Gly Ala  Leu Ser Leu 
    2240                 2245                 2250             


Cys Ser  Ala Asp Thr Ser Leu  Gly Asp Arg Ala Asp  Thr Ser Leu 
    2255                 2260                 2265             


Pro Gln  Thr Gln Gly Pro Gly  Leu Leu Cys Ser Pro  Gly Val Ser 
    2270                 2275                 2280             


Ala Ala  Ala Leu Ala Leu Gln  Trp Ala Glu Ser Pro  Pro Ala Asp 
    2285                 2290                 2295             


Asp His  His Val Gln Arg Thr  Ala Val Glu Lys Asp  Val Glu Asp 
    2300                 2305                 2310             


Phe Ile  Thr Thr Ser Phe Asp  Ser Gln Glu Thr Leu  Ser Ser Pro 
    2315                 2320                 2325             


Pro Pro  Gly Leu Glu Gly Lys  Ala Asp Arg Ser Glu  Lys Ser Asp 
    2330                 2335                 2340             


Gly Ser  Gly Phe Gly Ala Arg  Leu Ser Pro Gly Ser  Gly Gly Pro 
    2345                 2350                 2355             


Glu Ala  Gln Thr Ala Gly Pro  Val Thr Pro Ala Ser  Ile Ser Gly 
    2360                 2365                 2370             


Arg Phe  Gln Pro Leu Pro Glu  Ala Met Lys Glu Lys  Glu Val Arg 
    2375                 2380                 2385             


Pro Lys  His Val Lys Ala Leu  Leu Gln Met Val Arg  Asp Glu Ser 
    2390                 2395                 2400             


His Gln  Ile Leu Ala Leu Ser  Glu Gly Leu Ala Pro  Pro Ser Gly 
    2405                 2410                 2415             


Glu Pro  His Pro Pro Arg Lys  Glu Asp Glu Ile Gln  Asp Ile Ser 
    2420                 2425                 2430             


Leu His  Gly Gly Lys Thr Gln  Glu Val Pro Thr Ala  Cys Pro Asp 
    2435                 2440                 2445             


Trp Arg  Gly Asp Leu Leu Gln  Val Val Gln Glu Ala  Phe Glu Lys 
    2450                 2455                 2460             


Glu Gln  Glu Met Gln Gly Val  Glu Leu Gln Pro Arg  Leu Ser Gly 
    2465                 2470                 2475             


Ser Asp  Leu Gly Gly His Ser  Ser Leu Leu Glu Arg  Leu Glu Lys 
    2480                 2485                 2490             


Ile Ile  Arg Glu Gln Gly Asp  Leu Gln Glu Lys Ser  Leu Glu His 
    2495                 2500                 2505             


Leu Arg  Leu Pro Asp Arg Ser  Ser Leu Leu Ser Glu  Ile Gln Ala 
    2510                 2515                 2520             


Leu Arg  Ala Gln Leu Arg Met  Thr His Leu Gln Asn  Gln Glu Lys 
    2525                 2530                 2535             


Leu Gln  His Leu Arg Thr Ala  Leu Thr Ser Ala Glu  Ala Arg Gly 
    2540                 2545                 2550             


Ser Gln  Gln Glu His Gln Leu  Arg Arg Gln Val Glu  Leu Leu Ala 
    2555                 2560                 2565             


Tyr Lys  Val Glu Gln Glu Lys  Cys Ile Ala Gly Asp  Leu Gln Lys 
    2570                 2575                 2580             


Thr Leu  Ser Glu Glu Gln Glu  Lys Ala Asn Ser Val  Gln Lys Leu 
    2585                 2590                 2595             


Leu Ala  Ala Glu Gln Thr Val  Val Arg Asp Leu Lys  Ser Asp Leu 
    2600                 2605                 2610             


Cys Glu  Ser Arg Gln Lys Ser  Glu Gln Leu Ser Arg  Ser Leu Cys 
    2615                 2620                 2625             


Glu Val  Gln Gln Glu Val Leu  Gln Leu Arg Ser Met  Leu Ser Ser 
    2630                 2635                 2640             


Lys Glu  Asn Glu Leu Lys Ala  Ala Leu Gln Glu Leu  Glu Ser Glu 
    2645                 2650                 2655             


Gln Gly  Lys Gly Arg Ala Leu  Gln Ser Gln Leu Glu  Glu Glu Gln 
    2660                 2665                 2670             


Leu Arg  His Leu Gln Arg Glu  Ser Gln Ser Ala Lys  Ala Leu Glu 
    2675                 2680                 2685             


Glu Leu  Arg Ala Ser Leu Glu  Thr Gln Arg Ala Gln  Ser Ser Arg 
    2690                 2695                 2700             


Leu Cys  Val Ala Leu Lys His  Glu Gln Thr Ala Lys  Asp Asn Leu 
    2705                 2710                 2715             


Gln Lys  Glu Leu Arg Ile Glu  His Ser Arg Cys Glu  Ala Leu Leu 
    2720                 2725                 2730             


Ala Gln  Glu Arg Ser Gln Leu  Ser Glu Leu Gln Lys  Asp Leu Ala 
    2735                 2740                 2745             


Ala Glu  Lys Ser Arg Thr Leu  Glu Leu Ser Glu Ala  Leu Arg His 
    2750                 2755                 2760             


Glu Arg  Leu Leu Thr Glu Gln  Leu Ser Gln Arg Thr  Gln Glu Ala 
    2765                 2770                 2775             


Cys Val  His Gln Asp Thr Gln  Ala His His Ala Leu  Leu Gln Lys 
    2780                 2785                 2790             


Leu Lys  Glu Glu Lys Ser Arg  Val Val Asp Leu Gln  Ala Met Leu 
    2795                 2800                 2805             


Glu Lys  Val Gln Gln Gln Ala  Leu His Ser Gln Gln  Gln Leu Glu 
    2810                 2815                 2820             


Ala Glu  Ala Gln Lys His Cys  Glu Ala Leu Arg Arg  Glu Lys Glu 
    2825                 2830                 2835             


Val Ser  Ala Thr Leu Lys Ser  Thr Val Glu Ala Leu  His Thr Gln 
    2840                 2845                 2850             


Lys Arg  Glu Leu Arg Cys Ser  Leu Glu Arg Glu Arg  Glu Lys Pro 
    2855                 2860                 2865             


Ala Trp  Leu Gln Ala Glu Leu  Glu Gln Ser His Pro  Arg Leu Lys 
    2870                 2875                 2880             


Glu Gln  Glu Gly Arg Lys Ala  Ala Arg Arg Ser Ala  Glu Ala Arg 
    2885                 2890                 2895             


Gln Ser  Pro Ala Ala Ala Glu  Gln Trp Arg Lys Trp  Gln Arg Asp 
    2900                 2905                 2910             


Lys Glu  Lys Leu Arg Glu Leu  Glu Leu Gln Arg Gln  Arg Asp Leu 
    2915                 2920                 2925             


His Lys  Ile Lys Gln Leu Gln  Gln Thr Val Arg Asp  Leu Glu Ser 
    2930                 2935                 2940             


Lys Asp  Glu Val Pro Gly Ser  Arg Leu His Leu Gly  Ser Ala Arg 
    2945                 2950                 2955             


Arg Ala  Ala Gly Ser Asp Ala  Asp His Leu Arg Glu  Gln Gln Arg 
    2960                 2965                 2970             


Glu Leu  Glu Ala Met Arg Gln  Arg Leu Leu Ser Ala  Ala Arg Leu 
    2975                 2980                 2985             


Leu Thr  Ser Phe Thr Ser Gln  Ala Val Asp Arg Thr  Val Asn Asp 
    2990                 2995                 3000             


Trp Thr  Ser Ser Asn Glu Lys  Ala Val Met Ser Leu  Leu His Thr 
    3005                 3010                 3015             


Leu Glu  Glu Leu Lys Ser Asp  Leu Ser Arg Pro Thr  Ser Ser Gln 
    3020                 3025                 3030             


Lys Lys  Met Ala Ala Glu Leu  Gln Phe Gln Phe Val  Asp Val Leu 
    3035                 3040                 3045             


Leu Lys  Asp Asn Val Ser Leu  Thr Lys Ala Leu Ser  Thr Val Thr 
    3050                 3055                 3060             


Gln Glu  Lys Leu Glu Leu Ser  Arg Ala Val Ser Lys  Leu Glu Lys 
    3065                 3070                 3075             


Leu Leu  Lys His His Leu Gln  Lys Gly Cys Ser Pro  Ser Arg Ser 
    3080                 3085                 3090             


Glu Arg  Ser Ala Trp Lys Pro  Asp Glu Thr Ala Pro  Gln Ser Ser 
    3095                 3100                 3105             


Leu Arg  Arg Pro Asp Pro Gly  Arg Leu Pro Pro Ala  Ala Ser Glu 
    3110                 3115                 3120             


Glu Ala  His Thr Ser Asn Val  Lys Met Glu Lys Leu  Tyr Leu His 
    3125                 3130                 3135             


Tyr Leu  Arg Ala Glu Ser Phe  Arg Lys Ala Leu Ile  Tyr Gln Lys 
    3140                 3145                 3150             


Lys Tyr  Leu Leu Leu Leu Ile  Gly Gly Phe Gln Asp  Ser Glu Gln 
    3155                 3160                 3165             


Glu Thr  Leu Ser Met Ile Ala  His Leu Gly Val Phe  Pro Ser Lys 
    3170                 3175                 3180             


Ala Glu  Arg Lys Ile Thr Ser  Arg Pro Phe Thr Arg  Phe Arg Thr 
    3185                 3190                 3195             


Ala Val  Arg Val Val Ile Ala  Ile Leu Arg Leu Arg  Phe Leu Val 
    3200                 3205                 3210             


Lys Lys  Trp Gln Glu Val Asp  Arg Lys Gly Ala Leu  Ala Gln Gly 
    3215                 3220                 3225             


Lys Ala  Pro Arg Pro Gly Pro  Arg Ala Arg Gln Pro  Gln Ser Pro 
    3230                 3235                 3240             


Pro Arg  Thr Arg Glu Ser Pro  Pro Thr Arg Asp Val  Pro Ser Gly 
    3245                 3250                 3255             


His Thr  Arg Asp Pro Ala Arg  Gly Arg Arg Leu Ala  Ala Ala Ala 
    3260                 3265                 3270             


Ser Pro  His Ser Gly Gly Arg  Ala Thr Pro Ser Pro  Asn Ser Arg 
    3275                 3280                 3285             


Leu Glu  Arg Ser Leu Thr Ala  Ser Gln Asp Pro Glu  His Ser Leu 
    3290                 3295                 3300             


Thr Glu  Tyr Ile His His Leu  Glu Val Ile Gln Gln  Arg Leu Gly 
    3305                 3310                 3315             


Gly Val  Leu Pro Asp Ser Thr  Ser Lys Lys Ser Cys  His Pro Met 
    3320                 3325                 3330             


Ile Lys  Gln 
    3335     


<210>  3984
<211>  5936
<212>  DNA
<213>  Homosapiens

<400>  3984
gctgtcctgg ccgcgcccct gtcccgccgc ctcccgctcc tcgcctggcg gatgtaggtt     60

gttggcctga ggggagctac gtagccgagg tttgcgctgc cgccgccagg cccggtccgg    120

ttccagcctc tgcccggacg ctagccggcc tggccatggc tgaccgcggg tgcccgctgg    180

aggcggcgcc gctgcctgcc gaggtgcggg agagcctggc tgagctggag ctggagctgt    240

cggaaggtga catcactcaa aaaggatatg aaaagaaaag ggcaaagctg cttgcacgtt    300

atataccgct tattcaagga atagacccat ctctgcaagc agagaataga attcctgggc    360

cctcacaaac cacggccgct gcacccaagc agcagaagtc tcggcccacc gcctcgaggg    420

atgagcgctt ccggtcagat gtccacactg aagccgtgca agcagctttg gccaaataca    480

aagagaggaa gatgcctatg ccttcgaaga gacgttctgt ccttgtgcat tcgtctgtgg    540

aaacctacac ccctccagac acgtcgtctg cctcagaaga tgagggctct ttacggcgac    600

ccgggcgact cacctccact ccgctccaga gccattccag cgtcgagccc tggctcgacc    660

gggtcattca gggctcgtcc acctcatcct ctgcatcctc cacctcatct cacccgggag    720

ggagacccac cactgctccc agtgctgcag ccacgccggg ggccgccgct accactgcac    780

tcgcaggcct cgaggcccac acccacatag atctgcattc tgcccctcct gatgtcacca    840

cgggcctcgt ggagcattcg tactttgagc gtccacaggt ggcttctgtg agaagtgttc    900

ctcgggggtg cagcgggagc atgctggaaa cagcagatgg tgtccctgtg aacagcagag    960

tgtcctccaa aatccagcag cttctgaaca ccctgaagag gccaaagcgc cctccactga   1020

aggagttctt tgtggatgat tttgaggaat tgttggaagt tcagcaacca gatccaaatc   1080

agccaaagcc tgagggaagc gagacgagtg tgctgagagg ggagcctctc actgcaggtg   1140

tcccccgacc gccgtcgctg ttggccacct tgcagcgctg gggcacaaca cagcccaaat   1200

ccccctgtct gactgccttg gatacaactg ggaaagccgt ctacactctc acctatggta   1260

aactttggag tcggagttta aaactagctt atactctact taataaactg acaagtaaga   1320

atgaacctct acttaaacct ggagacagag tggcgctcgt gtttccgaat agtgaccctg   1380

tgatgttcat ggttgcattt tatgggtgtc tcctggcaga gctggttcct gtccccatag   1440

aagtgccatt aacaagaaag gatgcaggca gccagcaggt tgggtttctg ctgggcagct   1500

gtggagtctt cttggccctg accacagacg cttgtcagaa aggcctcccc aaggcacaga   1560

caggagaggt ggcagctttc aaaggttggc ccccgctctc ctggctagtg attgatggga   1620

agcatctagc caagccccca aaggactggc accctctggc ccaggacaca gggactggga   1680

ctgcctacat tgagtataaa accagcaaag aaggcagtac ggtgggggtc acagtgtccc   1740

acgcatccct gctggcacag tgccgggctc tgacccaggc gtgcgggtac tcagaagctg   1800

aaacattaac aaacgtgctg gatttcaaaa gggatgctgg tctgtggcat ggcgtgttaa   1860

caagcgtcat gaacaggatg cacgtggtca gcgtccccta cgcgctgatg aaggcgaacc   1920

cactctcctg gatccagaaa gtgtgcttct ataaagctcg ggccgcgctg gtgaagtcgc   1980

gagacatgca ctggtctctc ctagctcagc ggggccagag ggacgtcagc ctcagctcac   2040

tgcgcatgct gattgtggcc gatggtgcca acccgtggtc gatctcctcc tgtgacgcct   2100

tcctcaacgt cttccagtcc agaggtctga ggccagaggt catctgtcct tgtgcaagtt   2160

ctcctgaggc gctgactgtc gccatccgca ggccacctga tctgggagga ccacctccaa   2220

gaaaagcagt cctgtcgatg aacggtctaa gttatggtgt tatcagagtg gatactgaag   2280

aaaagttgtc agtccttact gttcaggacg ttggtcaggt gatgcctgga gctaatgtat   2340

gtgttgtgaa gttagaaggt accccttatc tttgtaaaac tgatgaagtg ggagaaatat   2400

gcgtcagttc cagtgcaact ggcacagcgt actatggatt gcttggaatc acgaagaatg   2460

tgtttgaggc agttccggtc accacaggag gagcacccat ctttgacagg ccattcacca   2520

ggacaggcct gctgggcttc atcgggcctg acaacctggt cttcatcgtg ggcaaactgg   2580

acgggctgat ggtcactgga gttcgcagac acaatgcaga tgacgttgtg gccaccgcac   2640

tggccgtgga gcccatgaag tttgtctaca gaggcaggat cgctgtgttc tctgtgaccg   2700

tgctgcacga cgaccggatt gtcctggtgg ctgagcagcg gccggatgcc tcggaggagg   2760

acagcttcca gtggatgagc cgtgtgctgc aggccattga tagcatccac caggtgggcg   2820

tgtactgtct ggccctggtt cctgccaaca ccttgcccaa ggctcctctc ggagggattc   2880

acatttctga aaccaaacag cgctttctgg aagggacgct gcacccgtgt aatgtgctga   2940

tgtgccctca cacctgtgtt accaacctcc ccaaacctcg tcagaaacaa ccagaggttg   3000

gaccagcctc aatgatcgtg gggaacctgg ttgctgggaa gagaatcgct caggcttccg   3060

ggagagagct cgcccacctg gaggacagcg accaggcacg gaagttcctg ttcctggctg   3120

acgtgctgca gtggcgtgcc cacaccactc ctgaccaccc gctgttcttg ctgctgaacg   3180

ccaagggcac cgtcacaagc actgcaacct gtgtccagct gcacaaaagg gctgagagag   3240

tggccgcggc tctgatggag aagggaagac tgagtgttgg ggaccatgtg gctctggtct   3300

acccaccagg ggtggacctc attgccgcgt tctatggctg cttgtactgt ggctgcgtgc   3360

ctgtcaccgt gcggcccccg caccctcaga acctcggcac cacactgccc accgtcaaga   3420

tgatcgtgga ggtcagcaag tctgcatgcg tcctcaccac gcaggctgtc acacggctgc   3480

tcaggtccaa ggaggctgct gctgccgtgg acatcaggac ctggcccacc atcctagaca   3540

cagatgacat cccaaaaaag aagatagcaa gcgttttcag gcccccctcc cccgatgtcc   3600

tcgcatactt ggacttcagc gtgtcaacca ctgggatatt agcgggagtg aagatgtcgc   3660

acgcggccac aagcgcctta tgccgctcca taaagctgca gtgtgagctg tacccctcgc   3720

ggcagatcgc catctgcctc gacccctact gtggccttgg ttttgccctg tggtgtctgt   3780

gcagtgtcta ctcgggacac caatcagtgc tggtgccccc gctggagctg gagagcaacg   3840

tgtccctgtg gctgtcggcc gtcagccagt acaaggcccg cgtcaccttc tgctcctact   3900

ctgtgatgga gatgtgcacc aagggcctag gcgcacagac gggtgtcctc aggatgaagg   3960

gggtgaacct gtcatgtgtg cgcacgtgca tggtggtcgc cgaggagcgg cccaggattg   4020

cgctgaccca gtccttctcc aagctcttca aggacctggg cctgccggcc cgcgccgtaa   4080

gcaccacgtt cgggtgcagg gtcaacgtgg ccatctgcct ccagggcaca gctggcccgg   4140

accccacaac cgtctacgtg gacatgcggg cactgcgcca tgacagggtt cgtttggtag   4200

aacggggttc tccgcacagc ctgccattga tggagtctgg aaagatcctc cccggcgtga   4260

aggtcatcat cgcacacacc gagaccaaag gacccttggg agactcacac ctgggagaga   4320

tctgggtaag cagcccccac aatgccaccg ggtactacac cgtttacggg gaggaggcgc   4380

ttcatgccga ccacttcagt gcccggctga gttttggaga cacacagacc atctgggcaa   4440

ggaccggcta ccttggcttc cttcggcgaa cagagctcac tgatgccagt ggagggcggc   4500

acgatgcact gtatgtggtt gggtctctgg atgaaactct ggagctcaga ggcatgcggt   4560

accaccccat cgacattgag acctctgtca tccgagcaca caggagcatc gctgagtgtg   4620

ccgtattcac ctggaccaac ctgctggtgg tggtggtgga gctggatggg ctagagcagg   4680

atgccctgga cctggtggcc ctggtgacca acgtggtgct ggaggagcac tacctggtcg   4740

tgggagtggt ggtcatcgtg gacccagggg tgatccctat caactctcgg ggtgagaagc   4800

agcgcatgca cctgcgggac ggcttcctgg ctgaccagct ggaccccatc tatgtcgcct   4860

acaacatgtg agcgcagcac accggcccag gtgccggaga tgaatgagcc ccagcagtcc   4920

aaggtgtgat gtgggaagac accgcagagc tcactcaccg ggactcgccc ttcctgtgct   4980

cttacagatc cctctcaaca atccccgcat ctccttttag aaagcacttc ctgaattatt   5040

taaagaaata ttttgaatct gccaagtaca tttacaaaaa cacggatgct ggtattttaa   5100

cagatggaga gacaaggaaa ggaaaggaaa ggcctggcat gggcattgtg aggaatcaca   5160

ggcaccgagg ttgttctctg ctgtactgca agtttgcact ttctttaggc taaaaatata   5220

gttcctgatt tttaaaattc agttatttat tcccacttca aatgacaagt tcatatatag   5280

aatttacggg agaaacttga gaccatttac ggggagaaac ttgattctgg gaagatagca   5340

gagtacaaac cagctgcctc acttctgttt cacagggagg ctgatggaaa aaggaagcaa   5400

gctggaccca tcctccctgc tcacagaggg cactgtggtc acacacagtg cctcctctgc   5460

cagttccttt attgaaagag gtgtgctggc tggccacggt ggcttacacc tgtaatccca   5520

gcactttggg aggccgaggc gagcagatca cgaggtcagg agaccgagac catcctggct   5580

aacatggtga aaccctgtct ctactaaaaa tacaaaaaat tagccgggtg tggtggtggg   5640

cgcctgtagt cccagctact tgggaggctg aggcaggaga atggtatgaa ccagggaggc   5700

ggagcttgca gtgagccgag atcacgctac tgcactccag cctgggtgac agcacgagat   5760

gccgtcttaa aaaaacaaaa aagaggtgtg ctgcttgtca gcatgtattg tcacggacac   5820

tcaataagtg ccattttgga ctgtcaaatt tagatgcttt gtttcagaaa gataagccag   5880

catttagttt taaatcactt tcctggtttg taacttgatg ctgtttagtt aaattg       5936


<210>  3985
<211>  1571
<212>  PRT
<213>  Homosapiens

<400>  3985

Met Ala Asp Arg Gly Cys Pro Leu Glu Ala Ala Pro Leu Pro Ala Glu 
1               5                   10                  15      


Val Arg Glu Ser Leu Ala Glu Leu Glu Leu Glu Leu Ser Glu Gly Asp 
            20                  25                  30          


Ile Thr Gln Lys Gly Tyr Glu Lys Lys Arg Ala Lys Leu Leu Ala Arg 
        35                  40                  45              


Tyr Ile Pro Leu Ile Gln Gly Ile Asp Pro Ser Leu Gln Ala Glu Asn 
    50                  55                  60                  


Arg Ile Pro Gly Pro Ser Gln Thr Thr Ala Ala Ala Pro Lys Gln Gln 
65                  70                  75                  80  


Lys Ser Arg Pro Thr Ala Ser Arg Asp Glu Arg Phe Arg Ser Asp Val 
                85                  90                  95      


His Thr Glu Ala Val Gln Ala Ala Leu Ala Lys Tyr Lys Glu Arg Lys 
            100                 105                 110         


Met Pro Met Pro Ser Lys Arg Arg Ser Val Leu Val His Ser Ser Val 
        115                 120                 125             


Glu Thr Tyr Thr Pro Pro Asp Thr Ser Ser Ala Ser Glu Asp Glu Gly 
    130                 135                 140                 


Ser Leu Arg Arg Pro Gly Arg Leu Thr Ser Thr Pro Leu Gln Ser His 
145                 150                 155                 160 


Ser Ser Val Glu Pro Trp Leu Asp Arg Val Ile Gln Gly Ser Ser Thr 
                165                 170                 175     


Ser Ser Ser Ala Ser Ser Thr Ser Ser His Pro Gly Gly Arg Pro Thr 
            180                 185                 190         


Thr Ala Pro Ser Ala Ala Ala Thr Pro Gly Ala Ala Ala Thr Thr Ala 
        195                 200                 205             


Leu Ala Gly Leu Glu Ala His Thr His Ile Asp Leu His Ser Ala Pro 
    210                 215                 220                 


Pro Asp Val Thr Thr Gly Leu Val Glu His Ser Tyr Phe Glu Arg Pro 
225                 230                 235                 240 


Gln Val Ala Ser Val Arg Ser Val Pro Arg Gly Cys Ser Gly Ser Met 
                245                 250                 255     


Leu Glu Thr Ala Asp Gly Val Pro Val Asn Ser Arg Val Ser Ser Lys 
            260                 265                 270         


Ile Gln Gln Leu Leu Asn Thr Leu Lys Arg Pro Lys Arg Pro Pro Leu 
        275                 280                 285             


Lys Glu Phe Phe Val Asp Asp Phe Glu Glu Leu Leu Glu Val Gln Gln 
    290                 295                 300                 


Pro Asp Pro Asn Gln Pro Lys Pro Glu Gly Ser Glu Thr Ser Val Leu 
305                 310                 315                 320 


Arg Gly Glu Pro Leu Thr Ala Gly Val Pro Arg Pro Pro Ser Leu Leu 
                325                 330                 335     


Ala Thr Leu Gln Arg Trp Gly Thr Thr Gln Pro Lys Ser Pro Cys Leu 
            340                 345                 350         


Thr Ala Leu Asp Thr Thr Gly Lys Ala Val Tyr Thr Leu Thr Tyr Gly 
        355                 360                 365             


Lys Leu Trp Ser Arg Ser Leu Lys Leu Ala Tyr Thr Leu Leu Asn Lys 
    370                 375                 380                 


Leu Thr Ser Lys Asn Glu Pro Leu Leu Lys Pro Gly Asp Arg Val Ala 
385                 390                 395                 400 


Leu Val Phe Pro Asn Ser Asp Pro Val Met Phe Met Val Ala Phe Tyr 
                405                 410                 415     


Gly Cys Leu Leu Ala Glu Leu Val Pro Val Pro Ile Glu Val Pro Leu 
            420                 425                 430         


Thr Arg Lys Asp Ala Gly Ser Gln Gln Val Gly Phe Leu Leu Gly Ser 
        435                 440                 445             


Cys Gly Val Phe Leu Ala Leu Thr Thr Asp Ala Cys Gln Lys Gly Leu 
    450                 455                 460                 


Pro Lys Ala Gln Thr Gly Glu Val Ala Ala Phe Lys Gly Trp Pro Pro 
465                 470                 475                 480 


Leu Ser Trp Leu Val Ile Asp Gly Lys His Leu Ala Lys Pro Pro Lys 
                485                 490                 495     


Asp Trp His Pro Leu Ala Gln Asp Thr Gly Thr Gly Thr Ala Tyr Ile 
            500                 505                 510         


Glu Tyr Lys Thr Ser Lys Glu Gly Ser Thr Val Gly Val Thr Val Ser 
        515                 520                 525             


His Ala Ser Leu Leu Ala Gln Cys Arg Ala Leu Thr Gln Ala Cys Gly 
    530                 535                 540                 


Tyr Ser Glu Ala Glu Thr Leu Thr Asn Val Leu Asp Phe Lys Arg Asp 
545                 550                 555                 560 


Ala Gly Leu Trp His Gly Val Leu Thr Ser Val Met Asn Arg Met His 
                565                 570                 575     


Val Val Ser Val Pro Tyr Ala Leu Met Lys Ala Asn Pro Leu Ser Trp 
            580                 585                 590         


Ile Gln Lys Val Cys Phe Tyr Lys Ala Arg Ala Ala Leu Val Lys Ser 
        595                 600                 605             


Arg Asp Met His Trp Ser Leu Leu Ala Gln Arg Gly Gln Arg Asp Val 
    610                 615                 620                 


Ser Leu Ser Ser Leu Arg Met Leu Ile Val Ala Asp Gly Ala Asn Pro 
625                 630                 635                 640 


Trp Ser Ile Ser Ser Cys Asp Ala Phe Leu Asn Val Phe Gln Ser Arg 
                645                 650                 655     


Gly Leu Arg Pro Glu Val Ile Cys Pro Cys Ala Ser Ser Pro Glu Ala 
            660                 665                 670         


Leu Thr Val Ala Ile Arg Arg Pro Pro Asp Leu Gly Gly Pro Pro Pro 
        675                 680                 685             


Arg Lys Ala Val Leu Ser Met Asn Gly Leu Ser Tyr Gly Val Ile Arg 
    690                 695                 700                 


Val Asp Thr Glu Glu Lys Leu Ser Val Leu Thr Val Gln Asp Val Gly 
705                 710                 715                 720 


Gln Val Met Pro Gly Ala Asn Val Cys Val Val Lys Leu Glu Gly Thr 
                725                 730                 735     


Pro Tyr Leu Cys Lys Thr Asp Glu Val Gly Glu Ile Cys Val Ser Ser 
            740                 745                 750         


Ser Ala Thr Gly Thr Ala Tyr Tyr Gly Leu Leu Gly Ile Thr Lys Asn 
        755                 760                 765             


Val Phe Glu Ala Val Pro Val Thr Thr Gly Gly Ala Pro Ile Phe Asp 
    770                 775                 780                 


Arg Pro Phe Thr Arg Thr Gly Leu Leu Gly Phe Ile Gly Pro Asp Asn 
785                 790                 795                 800 


Leu Val Phe Ile Val Gly Lys Leu Asp Gly Leu Met Val Thr Gly Val 
                805                 810                 815     


Arg Arg His Asn Ala Asp Asp Val Val Ala Thr Ala Leu Ala Val Glu 
            820                 825                 830         


Pro Met Lys Phe Val Tyr Arg Gly Arg Ile Ala Val Phe Ser Val Thr 
        835                 840                 845             


Val Leu His Asp Asp Arg Ile Val Leu Val Ala Glu Gln Arg Pro Asp 
    850                 855                 860                 


Ala Ser Glu Glu Asp Ser Phe Gln Trp Met Ser Arg Val Leu Gln Ala 
865                 870                 875                 880 


Ile Asp Ser Ile His Gln Val Gly Val Tyr Cys Leu Ala Leu Val Pro 
                885                 890                 895     


Ala Asn Thr Leu Pro Lys Ala Pro Leu Gly Gly Ile His Ile Ser Glu 
            900                 905                 910         


Thr Lys Gln Arg Phe Leu Glu Gly Thr Leu His Pro Cys Asn Val Leu 
        915                 920                 925             


Met Cys Pro His Thr Cys Val Thr Asn Leu Pro Lys Pro Arg Gln Lys 
    930                 935                 940                 


Gln Pro Glu Val Gly Pro Ala Ser Met Ile Val Gly Asn Leu Val Ala 
945                 950                 955                 960 


Gly Lys Arg Ile Ala Gln Ala Ser Gly Arg Glu Leu Ala His Leu Glu 
                965                 970                 975     


Asp Ser Asp Gln Ala Arg Lys Phe Leu Phe Leu Ala Asp Val Leu Gln 
            980                 985                 990         


Trp Arg Ala His Thr Thr Pro Asp  His Pro Leu Phe Leu  Leu Leu Asn 
        995                 1000                 1005             


Ala Lys  Gly Thr Val Thr Ser  Thr Ala Thr Cys Val  Gln Leu His 
    1010                 1015                 1020             


Lys Arg  Ala Glu Arg Val Ala  Ala Ala Leu Met Glu  Lys Gly Arg 
    1025                 1030                 1035             


Leu Ser  Val Gly Asp His Val  Ala Leu Val Tyr Pro  Pro Gly Val 
    1040                 1045                 1050             


Asp Leu  Ile Ala Ala Phe Tyr  Gly Cys Leu Tyr Cys  Gly Cys Val 
    1055                 1060                 1065             


Pro Val  Thr Val Arg Pro Pro  His Pro Gln Asn Leu  Gly Thr Thr 
    1070                 1075                 1080             


Leu Pro  Thr Val Lys Met Ile  Val Glu Val Ser Lys  Ser Ala Cys 
    1085                 1090                 1095             


Val Leu  Thr Thr Gln Ala Val  Thr Arg Leu Leu Arg  Ser Lys Glu 
    1100                 1105                 1110             


Ala Ala  Ala Ala Val Asp Ile  Arg Thr Trp Pro Thr  Ile Leu Asp 
    1115                 1120                 1125             


Thr Asp  Asp Ile Pro Lys Lys  Lys Ile Ala Ser Val  Phe Arg Pro 
    1130                 1135                 1140             


Pro Ser  Pro Asp Val Leu Ala  Tyr Leu Asp Phe Ser  Val Ser Thr 
    1145                 1150                 1155             


Thr Gly  Ile Leu Ala Gly Val  Lys Met Ser His Ala  Ala Thr Ser 
    1160                 1165                 1170             


Ala Leu  Cys Arg Ser Ile Lys  Leu Gln Cys Glu Leu  Tyr Pro Ser 
    1175                 1180                 1185             


Arg Gln  Ile Ala Ile Cys Leu  Asp Pro Tyr Cys Gly  Leu Gly Phe 
    1190                 1195                 1200             


Ala Leu  Trp Cys Leu Cys Ser  Val Tyr Ser Gly His  Gln Ser Val 
    1205                 1210                 1215             


Leu Val  Pro Pro Leu Glu Leu  Glu Ser Asn Val Ser  Leu Trp Leu 
    1220                 1225                 1230             


Ser Ala  Val Ser Gln Tyr Lys  Ala Arg Val Thr Phe  Cys Ser Tyr 
    1235                 1240                 1245             


Ser Val  Met Glu Met Cys Thr  Lys Gly Leu Gly Ala  Gln Thr Gly 
    1250                 1255                 1260             


Val Leu  Arg Met Lys Gly Val  Asn Leu Ser Cys Val  Arg Thr Cys 
    1265                 1270                 1275             


Met Val  Val Ala Glu Glu Arg  Pro Arg Ile Ala Leu  Thr Gln Ser 
    1280                 1285                 1290             


Phe Ser  Lys Leu Phe Lys Asp  Leu Gly Leu Pro Ala  Arg Ala Val 
    1295                 1300                 1305             


Ser Thr  Thr Phe Gly Cys Arg  Val Asn Val Ala Ile  Cys Leu Gln 
    1310                 1315                 1320             


Gly Thr  Ala Gly Pro Asp Pro  Thr Thr Val Tyr Val  Asp Met Arg 
    1325                 1330                 1335             


Ala Leu  Arg His Asp Arg Val  Arg Leu Val Glu Arg  Gly Ser Pro 
    1340                 1345                 1350             


His Ser  Leu Pro Leu Met Glu  Ser Gly Lys Ile Leu  Pro Gly Val 
    1355                 1360                 1365             


Lys Val  Ile Ile Ala His Thr  Glu Thr Lys Gly Pro  Leu Gly Asp 
    1370                 1375                 1380             


Ser His  Leu Gly Glu Ile Trp  Val Ser Ser Pro His  Asn Ala Thr 
    1385                 1390                 1395             


Gly Tyr  Tyr Thr Val Tyr Gly  Glu Glu Ala Leu His  Ala Asp His 
    1400                 1405                 1410             


Phe Ser  Ala Arg Leu Ser Phe  Gly Asp Thr Gln Thr  Ile Trp Ala 
    1415                 1420                 1425             


Arg Thr  Gly Tyr Leu Gly Phe  Leu Arg Arg Thr Glu  Leu Thr Asp 
    1430                 1435                 1440             


Ala Ser  Gly Gly Arg His Asp  Ala Leu Tyr Val Val  Gly Ser Leu 
    1445                 1450                 1455             


Asp Glu  Thr Leu Glu Leu Arg  Gly Met Arg Tyr His  Pro Ile Asp 
    1460                 1465                 1470             


Ile Glu  Thr Ser Val Ile Arg  Ala His Arg Ser Ile  Ala Glu Cys 
    1475                 1480                 1485             


Ala Val  Phe Thr Trp Thr Asn  Leu Leu Val Val Val  Val Glu Leu 
    1490                 1495                 1500             


Asp Gly  Leu Glu Gln Asp Ala  Leu Asp Leu Val Ala  Leu Val Thr 
    1505                 1510                 1515             


Asn Val  Val Leu Glu Glu His  Tyr Leu Val Val Gly  Val Val Val 
    1520                 1525                 1530             


Ile Val  Asp Pro Gly Val Ile  Pro Ile Asn Ser Arg  Gly Glu Lys 
    1535                 1540                 1545             


Gln Arg  Met His Leu Arg Asp  Gly Phe Leu Ala Asp  Gln Leu Asp 
    1550                 1555                 1560             


Pro Ile  Tyr Val Ala Tyr Asn  Met 
    1565                 1570     


<210>  3986
<211>  3042
<212>  DNA
<213>  Homosapiens

<400>  3986
gctgtcctgg ccgcgcccct gtcccgccgc ctcccgctcc tcgcctggcg gatgtaggtt     60

gttggcctga ggggagctac gtagccgagg tttgcgctgc cgccgccagg cccggtccgg    120

ttccagcctc tgcccggacg ctagccggcc tggccatggc tgaccgcggg tgcccgctgg    180

aggcggcgcc gctgcctgcc gaggtgcggg agagcctggc tgagctggag ctggagctgt    240

cggaaggtga catcactcaa aaaggatatg aaaagaaaag ggcaaagctg cttgcacgtt    300

atataccgct tattcaagga atagacccat ctctgcaagc agagaataga attcctgggc    360

cctcacaaac cacggccgct gcacccaagc agcagaagtc tcggcccacc gcctcgaggg    420

atgagcgctt ccggtcagat gtccacactg aagccgtgca agcagctttg gccaaataca    480

aagagaggaa gatgcctatg ccttcgaaga gacgttctgt ccttgtgcat tcgtctgtgg    540

aaacctacac ccctccagac acgtcgtctg cctcagaaga tgagggctct ttacggcgac    600

ccgggcgact cacctccact ccgctccaga gccattccag cgtcgagccc tggctcgacc    660

gggtcattca gggctcgtcc acctcatcct ctgcatcctc cacctcatct cacccgggag    720

ggagacccac cactgctccc agtgctgcag ccacgccggg ggccgccgct accactgcac    780

tcgcaggcct cgaggcccac acccacatag atctgcattc tgcccctcct gatgtcacca    840

cgggcctcgt ggagcattcg tactttgagc gtccacaggt ggcttctgtg agaagtgttc    900

ctcgggggtg cagcgggagc atgctggaaa cagcagatgg tgtccctgtg aacagcagag    960

tgtcctccaa aatccagcag cttctgaaca ccctgaagag gccaaagcgc cctccactga   1020

aggagttctt tgtggatgat tttgaggaat tgttggaagt tcagcaacca gatccaaatc   1080

agccaaagcc tgagggaagc gagacgagtg tgctgagagg ggagcctctc actgcaggtg   1140

tcccccgacc gccgtcgctg ttggccacct tgcagcgctg gggcacaaca cagcccaaat   1200

ccccctgtct gactgccttg gatacaactg ggaaagccgt ctacactctc acctatggta   1260

aactttggag tcggagttta aaactagctt atactctact taataaactg acaagtaaga   1320

atgaacctct acttaaacct ggagacagag tggcgctcgt gtttccgaat agtgaccctg   1380

tgatgttcat ggttgcattt tatgggtgtc tcctggcaga gctggttcct gtccccatag   1440

aagtgccatt aacaagaaag gatgcaggca gccagcaggt tgggtttctg ctgggcagct   1500

gtggagtctt cttggccctg accacagacg cttgtcagaa aggcctcccc aaggcacaga   1560

caggagaggt ggcagctttc aaaggttggc ccccgctctc ctggctagtg attgatggga   1620

agcatctagc caagccccca aaggactggc accctctggc ccaggacaca gggactggga   1680

ctgcctacat tgagtataaa accagcaaag aaggcagtac ggtgggggtc acagtgtccc   1740

acgcatccct gctggcacag tgccgggctc tgacccaggc gtgcgggtac tcagaagctg   1800

aaacattaac aaacgtgctg gatttcaaaa gggatgctgg tctgtggcat ggcgtgttaa   1860

caagcgtcat gaacaggatg cacgtggtca gcgtccccta cgcgctgatg aaggcgaacc   1920

cactctcctg gatccagaaa gtgtgcttct ataaagctcg ggccgcgctg gtgaagtcgc   1980

gagacatgca ctggtctctc ctagctcagc ggggccagag ggacgtcagc ctcagctcac   2040

tgcgcatgct gattgtggcc gatggtgcca acccgtggtc gatctcctcc tgtgacgcct   2100

tcctcaacgt cttccagtcc agaggtctga ggccagaggt catctgtcct tgtgcaagtt   2160

ctcctgaggc gctgactgtc gccatccgca ggccacctga tctgggagga ccacctccaa   2220

gaaaagcagt cctgtcgatg aacggtctaa gttatggtgt tatcagagtg gatactgaag   2280

aaaagttgtc agtccttact gttcaggacg ttggtcaggt gatgcctgga gctaatgtat   2340

gtgttgtgaa gttagaaggt accccttatc tttgtaaaac tgatgaagtg ggagaaatat   2400

gcgtcagttc cagtgcaact ggcacagcgt actatggatt gcttggaatc acgaagaatg   2460

tgtttgaggc agttccggtc accacaggag gagcacccat ctttgacagg ccattcacca   2520

ggacaggcct gctgggcttc atcgggcctg acaacctggt cttcatcgtg ggcaaactgg   2580

acgggctgat ggtcactgga gttcgcagac acaatgcaga tgacgttgtg gccaccgcac   2640

tggccgtgga gcccatgaag tttgtctaca gaggcaggat cgctgtgttc tctgtgaccg   2700

tgctgcacga cgaccggatt gtcctggtgg ctgagcagcg gccggatgcc tcggaggagg   2760

acagcttcca gtggatgagc cgtgtgctgc aggtgggcgc cccggcacgg cctatggttc   2820

ggtgaatctc ccaagctggc acccccactc cactccaagt gccaagtggt tggcttgtcc   2880

cgcccggtcc tccctggctc cagctttgtt tatctgtatt tttcattgca aattgacaaa   2940

ttacagctgt atgtatttac gggatacaaa gtgatgttat aatttatgaa tacaatatag   3000

aataattaat atatccaaaa aaaaaaaaaa aaaaaaaaaa aa                      3042


<210>  3987
<211>  889
<212>  PRT
<213>  Homosapiens

<400>  3987

Met Ala Asp Arg Gly Cys Pro Leu Glu Ala Ala Pro Leu Pro Ala Glu 
1               5                   10                  15      


Val Arg Glu Ser Leu Ala Glu Leu Glu Leu Glu Leu Ser Glu Gly Asp 
            20                  25                  30          


Ile Thr Gln Lys Gly Tyr Glu Lys Lys Arg Ala Lys Leu Leu Ala Arg 
        35                  40                  45              


Tyr Ile Pro Leu Ile Gln Gly Ile Asp Pro Ser Leu Gln Ala Glu Asn 
    50                  55                  60                  


Arg Ile Pro Gly Pro Ser Gln Thr Thr Ala Ala Ala Pro Lys Gln Gln 
65                  70                  75                  80  


Lys Ser Arg Pro Thr Ala Ser Arg Asp Glu Arg Phe Arg Ser Asp Val 
                85                  90                  95      


His Thr Glu Ala Val Gln Ala Ala Leu Ala Lys Tyr Lys Glu Arg Lys 
            100                 105                 110         


Met Pro Met Pro Ser Lys Arg Arg Ser Val Leu Val His Ser Ser Val 
        115                 120                 125             


Glu Thr Tyr Thr Pro Pro Asp Thr Ser Ser Ala Ser Glu Asp Glu Gly 
    130                 135                 140                 


Ser Leu Arg Arg Pro Gly Arg Leu Thr Ser Thr Pro Leu Gln Ser His 
145                 150                 155                 160 


Ser Ser Val Glu Pro Trp Leu Asp Arg Val Ile Gln Gly Ser Ser Thr 
                165                 170                 175     


Ser Ser Ser Ala Ser Ser Thr Ser Ser His Pro Gly Gly Arg Pro Thr 
            180                 185                 190         


Thr Ala Pro Ser Ala Ala Ala Thr Pro Gly Ala Ala Ala Thr Thr Ala 
        195                 200                 205             


Leu Ala Gly Leu Glu Ala His Thr His Ile Asp Leu His Ser Ala Pro 
    210                 215                 220                 


Pro Asp Val Thr Thr Gly Leu Val Glu His Ser Tyr Phe Glu Arg Pro 
225                 230                 235                 240 


Gln Val Ala Ser Val Arg Ser Val Pro Arg Gly Cys Ser Gly Ser Met 
                245                 250                 255     


Leu Glu Thr Ala Asp Gly Val Pro Val Asn Ser Arg Val Ser Ser Lys 
            260                 265                 270         


Ile Gln Gln Leu Leu Asn Thr Leu Lys Arg Pro Lys Arg Pro Pro Leu 
        275                 280                 285             


Lys Glu Phe Phe Val Asp Asp Phe Glu Glu Leu Leu Glu Val Gln Gln 
    290                 295                 300                 


Pro Asp Pro Asn Gln Pro Lys Pro Glu Gly Ser Glu Thr Ser Val Leu 
305                 310                 315                 320 


Arg Gly Glu Pro Leu Thr Ala Gly Val Pro Arg Pro Pro Ser Leu Leu 
                325                 330                 335     


Ala Thr Leu Gln Arg Trp Gly Thr Thr Gln Pro Lys Ser Pro Cys Leu 
            340                 345                 350         


Thr Ala Leu Asp Thr Thr Gly Lys Ala Val Tyr Thr Leu Thr Tyr Gly 
        355                 360                 365             


Lys Leu Trp Ser Arg Ser Leu Lys Leu Ala Tyr Thr Leu Leu Asn Lys 
    370                 375                 380                 


Leu Thr Ser Lys Asn Glu Pro Leu Leu Lys Pro Gly Asp Arg Val Ala 
385                 390                 395                 400 


Leu Val Phe Pro Asn Ser Asp Pro Val Met Phe Met Val Ala Phe Tyr 
                405                 410                 415     


Gly Cys Leu Leu Ala Glu Leu Val Pro Val Pro Ile Glu Val Pro Leu 
            420                 425                 430         


Thr Arg Lys Asp Ala Gly Ser Gln Gln Val Gly Phe Leu Leu Gly Ser 
        435                 440                 445             


Cys Gly Val Phe Leu Ala Leu Thr Thr Asp Ala Cys Gln Lys Gly Leu 
    450                 455                 460                 


Pro Lys Ala Gln Thr Gly Glu Val Ala Ala Phe Lys Gly Trp Pro Pro 
465                 470                 475                 480 


Leu Ser Trp Leu Val Ile Asp Gly Lys His Leu Ala Lys Pro Pro Lys 
                485                 490                 495     


Asp Trp His Pro Leu Ala Gln Asp Thr Gly Thr Gly Thr Ala Tyr Ile 
            500                 505                 510         


Glu Tyr Lys Thr Ser Lys Glu Gly Ser Thr Val Gly Val Thr Val Ser 
        515                 520                 525             


His Ala Ser Leu Leu Ala Gln Cys Arg Ala Leu Thr Gln Ala Cys Gly 
    530                 535                 540                 


Tyr Ser Glu Ala Glu Thr Leu Thr Asn Val Leu Asp Phe Lys Arg Asp 
545                 550                 555                 560 


Ala Gly Leu Trp His Gly Val Leu Thr Ser Val Met Asn Arg Met His 
                565                 570                 575     


Val Val Ser Val Pro Tyr Ala Leu Met Lys Ala Asn Pro Leu Ser Trp 
            580                 585                 590         


Ile Gln Lys Val Cys Phe Tyr Lys Ala Arg Ala Ala Leu Val Lys Ser 
        595                 600                 605             


Arg Asp Met His Trp Ser Leu Leu Ala Gln Arg Gly Gln Arg Asp Val 
    610                 615                 620                 


Ser Leu Ser Ser Leu Arg Met Leu Ile Val Ala Asp Gly Ala Asn Pro 
625                 630                 635                 640 


Trp Ser Ile Ser Ser Cys Asp Ala Phe Leu Asn Val Phe Gln Ser Arg 
                645                 650                 655     


Gly Leu Arg Pro Glu Val Ile Cys Pro Cys Ala Ser Ser Pro Glu Ala 
            660                 665                 670         


Leu Thr Val Ala Ile Arg Arg Pro Pro Asp Leu Gly Gly Pro Pro Pro 
        675                 680                 685             


Arg Lys Ala Val Leu Ser Met Asn Gly Leu Ser Tyr Gly Val Ile Arg 
    690                 695                 700                 


Val Asp Thr Glu Glu Lys Leu Ser Val Leu Thr Val Gln Asp Val Gly 
705                 710                 715                 720 


Gln Val Met Pro Gly Ala Asn Val Cys Val Val Lys Leu Glu Gly Thr 
                725                 730                 735     


Pro Tyr Leu Cys Lys Thr Asp Glu Val Gly Glu Ile Cys Val Ser Ser 
            740                 745                 750         


Ser Ala Thr Gly Thr Ala Tyr Tyr Gly Leu Leu Gly Ile Thr Lys Asn 
        755                 760                 765             


Val Phe Glu Ala Val Pro Val Thr Thr Gly Gly Ala Pro Ile Phe Asp 
    770                 775                 780                 


Arg Pro Phe Thr Arg Thr Gly Leu Leu Gly Phe Ile Gly Pro Asp Asn 
785                 790                 795                 800 


Leu Val Phe Ile Val Gly Lys Leu Asp Gly Leu Met Val Thr Gly Val 
                805                 810                 815     


Arg Arg His Asn Ala Asp Asp Val Val Ala Thr Ala Leu Ala Val Glu 
            820                 825                 830         


Pro Met Lys Phe Val Tyr Arg Gly Arg Ile Ala Val Phe Ser Val Thr 
        835                 840                 845             


Val Leu His Asp Asp Arg Ile Val Leu Val Ala Glu Gln Arg Pro Asp 
    850                 855                 860                 


Ala Ser Glu Glu Asp Ser Phe Gln Trp Met Ser Arg Val Leu Gln Val 
865                 870                 875                 880 


Gly Ala Pro Ala Arg Pro Met Val Arg 
                885                 


<210>  3988
<211>  2859
<212>  DNA
<213>  Homosapiens

<400>  3988
gctgtcctgg ccgcgcccct gtcccgccgc ctcccgctcc tcgcctggcg gatgtaggtt     60

gttggcctga ggggagctac gtagccgagg tttgcgctgc cgccgccagg cccggtccgg    120

ttccagcctc tgcccggacg ctagccggcc tggccatggc tgaccgcggg tgcccgctgg    180

aggcggcgcc gctgcctgcc gaggtgcggg agagcctggc tgagctggag ctggagctgt    240

cggaaggtga catcactcaa aaaggatatg aaaagaaaag ggcaaagctg cttgcacgtt    300

atataccgct tattcaagga atagacccat ctctgcaagc agagaataga attcctgggc    360

cctcacaaac cacggccgct gcacccaagc agcagaagtc tcggcccacc gcctcgaggg    420

atgagcgctt ccggtcagat gtccacactg aagccgtgca agcagctttg gccaaataca    480

aagagaggaa gatgcctatg ccttcgaaga gacgttctgt ccttgtgcat tcgtctgtgg    540

aaacctacac ccctccagac acgtcgtctg cctcagaaga tgagggctct ttacggcgac    600

ccgggcgact cacctccact ccgctccaga gccattccag cgtcgagccc tggctcgacc    660

gggtcattca gggctcgtcc acctcatcct ctgcatcctc cacctcatct cacccgggag    720

ggagacccac cactgctccc agtgctgcag ccacgccggg ggccgccgct accactgcac    780

tcgcaggcct cgaggcccac acccacatag atctgcattc tgcccctcct gatgtcacca    840

cgggcctcgt ggagcattcg tactttgagc gtccacaggt ggcttctgtg agaagtgttc    900

ctcgggggtg cagcgggagc atgctggaaa cagcagatgg tgtccctgtg aacagcagag    960

tgtcctccaa aatccagcag cttctgaaca ccctgaagag gccaaagcgc cctccactga   1020

aggagttctt tgtggatgat tttgaggaat tgttggaagt tcagcaacca gatccaaatc   1080

agccaaagcc tgagggaagc gagacgagtg tgctgagagg ggagcctctc actgcaggtg   1140

tcccccgacc gccgtcgctg ttggccacct tgcagcgctg gggcacaaca cagcccaaat   1200

ccccctgtct gactgccttg gatacaactg ggaaagccgt ctacactctc acctatggta   1260

aactttggag tcggagttta aaactagctt atactctact taataaactg acaagtaaga   1320

atgaacctct acttaaacct ggagacagag tggcgctcgt gtttccgaat agtgaccctg   1380

tgatgttcat ggttgcattt tatgggtgtc tcctggcaga gctggttcct gtccccatag   1440

aagtgccatt aacaagaaag gatgcaggca gccagcaggt tgggtttctg ctgggcagct   1500

gtggagtctt cttggccctg accacagacg cttgtcagaa aggcctcccc aaggcacaga   1560

caggagaggt ggcagctttc aaaggttggc ccccgctctc ctggctagtg attgatggga   1620

agcatctagc caagccccca aaggactggc accctctggc ccaggacaca gggactggga   1680

ctgcctacat tgagtataaa accagcaaag aaggcagtac ggtgggggtc acagtgtccc   1740

acgcatccct gctggcacag tgccgggctc tgacccaggc gtgcgggtac tcagaagctg   1800

aaacattaac aaacgtgctg gatttcaaaa gggatgctgg tctgtggcat ggcgtgttaa   1860

caagcgtcat gaacaggatg cacgtggtca gcgtccccta cgcgctgatg aaggcgaacc   1920

cactctcctg gatccagaaa gtgtgcttct ataaagctcg ggccgcgctg gtgaagtcgc   1980

gagacatgca ctggtctctc ctagctcagc ggggccagag ggacgtcagc ctcagctcac   2040

tgcgcatgct gattgtggcc gatggtgcca acccgtggtc gatctcctcc tgtgacgcct   2100

tcctcaacgt cttccagtcc agaggtctga ggccagaggt catctgtcct tgtgcaagtt   2160

ctcctgaggc gctgactgtc gccatccgca ggccacctga tctgggagga ccacctccaa   2220

gaaaagcagt cctgtcgatg aacggtctaa gttatggtgt tatcagagtg gatactgaag   2280

aaaagttgtc agtccttact gttcaggacg ttggtcaggt gatgcctgga gctaatgtat   2340

gtgttgtgaa gttagaaggt accccttatc tttgtaaaac tgatgaagtg ggagaaatat   2400

gcgtcagttc cagtgcaact ggcacagcgt actatggatt gcttggaatc acgaagaatg   2460

tgtttgaggc agttccggtc accacaggag gagcacccat ctttgacagg ccattcacca   2520

ggacaggcct gctgggcttc atcgggcctg acaacctggt cttcatcgtg ggcaaactgg   2580

acgggctgat ggtcactgga gttcgcagac acaatgcaga tgacgttgtg gccaccgcac   2640

tggccgtgga gcccatgaag tttgtctaca gaggcaggtg atgcgctgcg gacccccacg   2700

ccgggagtag attccttcat ttgcagctcg ggaagtcttt gtgcagtaga tggaaagccc   2760

agcaaacttg aattcacaaa gcctaaaaat tgttgtacat cagaaaactc ctaaagtaaa   2820

aggaaaatat ttgcagcaat gaaaaaaaaa aaaaaaaaa                          2859


<210>  3989
<211>  841
<212>  PRT
<213>  Homosapiens

<400>  3989

Met Ala Asp Arg Gly Cys Pro Leu Glu Ala Ala Pro Leu Pro Ala Glu 
1               5                   10                  15      


Val Arg Glu Ser Leu Ala Glu Leu Glu Leu Glu Leu Ser Glu Gly Asp 
            20                  25                  30          


Ile Thr Gln Lys Gly Tyr Glu Lys Lys Arg Ala Lys Leu Leu Ala Arg 
        35                  40                  45              


Tyr Ile Pro Leu Ile Gln Gly Ile Asp Pro Ser Leu Gln Ala Glu Asn 
    50                  55                  60                  


Arg Ile Pro Gly Pro Ser Gln Thr Thr Ala Ala Ala Pro Lys Gln Gln 
65                  70                  75                  80  


Lys Ser Arg Pro Thr Ala Ser Arg Asp Glu Arg Phe Arg Ser Asp Val 
                85                  90                  95      


His Thr Glu Ala Val Gln Ala Ala Leu Ala Lys Tyr Lys Glu Arg Lys 
            100                 105                 110         


Met Pro Met Pro Ser Lys Arg Arg Ser Val Leu Val His Ser Ser Val 
        115                 120                 125             


Glu Thr Tyr Thr Pro Pro Asp Thr Ser Ser Ala Ser Glu Asp Glu Gly 
    130                 135                 140                 


Ser Leu Arg Arg Pro Gly Arg Leu Thr Ser Thr Pro Leu Gln Ser His 
145                 150                 155                 160 


Ser Ser Val Glu Pro Trp Leu Asp Arg Val Ile Gln Gly Ser Ser Thr 
                165                 170                 175     


Ser Ser Ser Ala Ser Ser Thr Ser Ser His Pro Gly Gly Arg Pro Thr 
            180                 185                 190         


Thr Ala Pro Ser Ala Ala Ala Thr Pro Gly Ala Ala Ala Thr Thr Ala 
        195                 200                 205             


Leu Ala Gly Leu Glu Ala His Thr His Ile Asp Leu His Ser Ala Pro 
    210                 215                 220                 


Pro Asp Val Thr Thr Gly Leu Val Glu His Ser Tyr Phe Glu Arg Pro 
225                 230                 235                 240 


Gln Val Ala Ser Val Arg Ser Val Pro Arg Gly Cys Ser Gly Ser Met 
                245                 250                 255     


Leu Glu Thr Ala Asp Gly Val Pro Val Asn Ser Arg Val Ser Ser Lys 
            260                 265                 270         


Ile Gln Gln Leu Leu Asn Thr Leu Lys Arg Pro Lys Arg Pro Pro Leu 
        275                 280                 285             


Lys Glu Phe Phe Val Asp Asp Phe Glu Glu Leu Leu Glu Val Gln Gln 
    290                 295                 300                 


Pro Asp Pro Asn Gln Pro Lys Pro Glu Gly Ser Glu Thr Ser Val Leu 
305                 310                 315                 320 


Arg Gly Glu Pro Leu Thr Ala Gly Val Pro Arg Pro Pro Ser Leu Leu 
                325                 330                 335     


Ala Thr Leu Gln Arg Trp Gly Thr Thr Gln Pro Lys Ser Pro Cys Leu 
            340                 345                 350         


Thr Ala Leu Asp Thr Thr Gly Lys Ala Val Tyr Thr Leu Thr Tyr Gly 
        355                 360                 365             


Lys Leu Trp Ser Arg Ser Leu Lys Leu Ala Tyr Thr Leu Leu Asn Lys 
    370                 375                 380                 


Leu Thr Ser Lys Asn Glu Pro Leu Leu Lys Pro Gly Asp Arg Val Ala 
385                 390                 395                 400 


Leu Val Phe Pro Asn Ser Asp Pro Val Met Phe Met Val Ala Phe Tyr 
                405                 410                 415     


Gly Cys Leu Leu Ala Glu Leu Val Pro Val Pro Ile Glu Val Pro Leu 
            420                 425                 430         


Thr Arg Lys Asp Ala Gly Ser Gln Gln Val Gly Phe Leu Leu Gly Ser 
        435                 440                 445             


Cys Gly Val Phe Leu Ala Leu Thr Thr Asp Ala Cys Gln Lys Gly Leu 
    450                 455                 460                 


Pro Lys Ala Gln Thr Gly Glu Val Ala Ala Phe Lys Gly Trp Pro Pro 
465                 470                 475                 480 


Leu Ser Trp Leu Val Ile Asp Gly Lys His Leu Ala Lys Pro Pro Lys 
                485                 490                 495     


Asp Trp His Pro Leu Ala Gln Asp Thr Gly Thr Gly Thr Ala Tyr Ile 
            500                 505                 510         


Glu Tyr Lys Thr Ser Lys Glu Gly Ser Thr Val Gly Val Thr Val Ser 
        515                 520                 525             


His Ala Ser Leu Leu Ala Gln Cys Arg Ala Leu Thr Gln Ala Cys Gly 
    530                 535                 540                 


Tyr Ser Glu Ala Glu Thr Leu Thr Asn Val Leu Asp Phe Lys Arg Asp 
545                 550                 555                 560 


Ala Gly Leu Trp His Gly Val Leu Thr Ser Val Met Asn Arg Met His 
                565                 570                 575     


Val Val Ser Val Pro Tyr Ala Leu Met Lys Ala Asn Pro Leu Ser Trp 
            580                 585                 590         


Ile Gln Lys Val Cys Phe Tyr Lys Ala Arg Ala Ala Leu Val Lys Ser 
        595                 600                 605             


Arg Asp Met His Trp Ser Leu Leu Ala Gln Arg Gly Gln Arg Asp Val 
    610                 615                 620                 


Ser Leu Ser Ser Leu Arg Met Leu Ile Val Ala Asp Gly Ala Asn Pro 
625                 630                 635                 640 


Trp Ser Ile Ser Ser Cys Asp Ala Phe Leu Asn Val Phe Gln Ser Arg 
                645                 650                 655     


Gly Leu Arg Pro Glu Val Ile Cys Pro Cys Ala Ser Ser Pro Glu Ala 
            660                 665                 670         


Leu Thr Val Ala Ile Arg Arg Pro Pro Asp Leu Gly Gly Pro Pro Pro 
        675                 680                 685             


Arg Lys Ala Val Leu Ser Met Asn Gly Leu Ser Tyr Gly Val Ile Arg 
    690                 695                 700                 


Val Asp Thr Glu Glu Lys Leu Ser Val Leu Thr Val Gln Asp Val Gly 
705                 710                 715                 720 


Gln Val Met Pro Gly Ala Asn Val Cys Val Val Lys Leu Glu Gly Thr 
                725                 730                 735     


Pro Tyr Leu Cys Lys Thr Asp Glu Val Gly Glu Ile Cys Val Ser Ser 
            740                 745                 750         


Ser Ala Thr Gly Thr Ala Tyr Tyr Gly Leu Leu Gly Ile Thr Lys Asn 
        755                 760                 765             


Val Phe Glu Ala Val Pro Val Thr Thr Gly Gly Ala Pro Ile Phe Asp 
    770                 775                 780                 


Arg Pro Phe Thr Arg Thr Gly Leu Leu Gly Phe Ile Gly Pro Asp Asn 
785                 790                 795                 800 


Leu Val Phe Ile Val Gly Lys Leu Asp Gly Leu Met Val Thr Gly Val 
                805                 810                 815     


Arg Arg His Asn Ala Asp Asp Val Val Ala Thr Ala Leu Ala Val Glu 
            820                 825                 830         


Pro Met Lys Phe Val Tyr Arg Gly Arg 
        835                 840     


<210>  3990
<211>  2909
<212>  DNA
<213>  Homosapiens

<400>  3990
gctgtcctgg ccgcgcccct gtcccgccgc ctcccgctcc tcgcctggcg gatgtaggtt     60

gttggcctga ggggagctac gtagccgagg tttgcgctgc cgccgccagg cccggtccgg    120

ttccagcctc tgcccggacg ctagccggcc tggccatggc tgaccgcggg tgcccgctgg    180

aggcggcgcc gctgcctgcc gaggtgcggg agagcctggc tgagctggag ctggagctgt    240

cggaaggtga catcactcaa aaaggatatg aaaagaaaag ggcaaagctg cttgcacgtt    300

atataccgct tattcaagga atagacccat ctctgcaagc agagaataga attcctgggc    360

cctcacaaac cacggccgct gcacccaagc agcagaagtc tcggcccacc gcctcgaggg    420

atgagcgctt ccggtcagat gtccacactg aagccgtgca agcagctttg gccaaataca    480

aagagaggaa gatgcctatg ccttcgaaga gacgttctgt ccttgtgcat tcgtctgtgg    540

aaacctacac ccctccagac acgtcgtctg cctcagaaga tgagggctct ttacggcgac    600

ccgggcgact cacctccact ccgctccaga gccattccag cgtcgagccc tggctcgacc    660

gggtcattca gggctcgtcc acctcatcct ctgcatcctc cacctcatct cacccgggag    720

ggagacccac cactgctccc agtgctgcag ccacgccggg ggccgccgct accactgcac    780

tcgcaggcct cgaggcccac acccacatag atctgcattc tgcccctcct gatgtcacca    840

cgggcctcgt ggagcattcg tactttgagc gtccacaggt ggcttctgtg agaagtgttc    900

ctcgggggtg cagcgggagc atgctggaaa cagcagatgg tgtccctgtg aacagcagag    960

tgtcctccaa aatccagcag cttctgaaca ccctgaagag gccaaagcgc cctccactga   1020

aggagttctt tgtggatgat tttgaggaat tgttggaagt tcagcaacca gatccaaatc   1080

agccaaagcc tgagggaagc gagacgagtg tgctgagagg ggagcctctc actgcaggtg   1140

tcccccgacc gccgtcgctg ttggccacct tgcagcgctg gggcacaaca cagcccaaat   1200

ccccctgtct gactgccttg gatacaactg ggaaagccgt ctacactctc acctatggta   1260

aactttggag tcggagttta aaactagctt atactctact taataaactg acaagtaaga   1320

atgaacctct acttaaacct ggagacagag tggcgctcgt gtttccgaat agtgaccctg   1380

tgatgttcat ggttgcattt tatgggtgtc tcctggcaga gctggttcct gtccccatag   1440

aagtgccatt aacaagaaag gatgcaggca gccagcaggt tgggtttctg ctgggcagct   1500

gtggagtctt cttggccctg accacagacg cttgtcagaa aggcctcccc aaggcacaga   1560

caggagaggt ggcagctttc aaaggttggc ccccgctctc ctggctagtg attgatggga   1620

agcatctagc caagccccca aaggactggc accctctggc ccaggacaca gggactggga   1680

ctgcctacat tgagtataaa accagcaaag aaggcagtac ggtgggggtc acagtgtccc   1740

acgcatccct gctggcacag tgccgggctc tgacccaggc gtgcgggtac tcagaagctg   1800

aaacattaac aaacgtgctg gatttcaaaa gggatgctgg tctgtggcat ggcgtgttaa   1860

caagcgtcat gaacaggatg cacgtggtca gcgtccccta cgcgctgatg aaggcgaacc   1920

cactctcctg gatccagaaa gtgtgcttct ataaagctcg ggccgcgctg gtgaagtcgc   1980

gagacatgca ctggtctctc ctagctcagc ggggccagag ggacgtcagc ctcagctcac   2040

tgcgcatgct gattgtggcc gatggtgcca acccgtggtc gatctcctcc tgtgacgcct   2100

tcctcaacgt cttccagtcc agaggtctga ggccagaggt catctgtcct tgtgcaagtt   2160

ctcctgaggc gctgactgtc gccatccgca ggccacctga tctgggagga ccacctccaa   2220

gaaaagcagt cctgtcgatg aacggtctaa gttatggtgt tatcagagtg gatactgaag   2280

aaaagttgtc agtccttact gttcaggacg ttggtcaggt gatgcctgga gctaatgtat   2340

gtgttgtgaa gttagaaggt accccttatc tttgtaaaac tgatgaagtg ggagaaatat   2400

gcgtcagttc cagtgcaact ggcacagcgt actatggatt gcttggaatc acgaagaatg   2460

tgtttgaggc agttccggtc accacaggag gagcacccat ctttgacagg ccattcacca   2520

ggacaggcct gctgggcttc atcgggcctg tgagtatgtc ctcctgtacc agcactggca   2580

gtcagagaag gtagggggtg tggctaaggg acacctcgtt gcagccccac ccttgtcctg   2640

gccgttcctg acctcccatg tggccttggt cggtggcgct gacctccctg cccatcaccc   2700

tacctgtgtg cagggccatc cacacctccg agactggtgc acagtcctgc acacaggcct   2760

gagtcggggg tccccggggt ggatgaggat gttttgcttt ttatatggag tggcaggttt   2820

gtgagtattc attatatcat tctttaccat tttggatgtc taaactattc aaaaataaat   2880

gcttctattt gtaaaaaaaa aaaaaaaaa                                     2909


<210>  3991
<211>  812
<212>  PRT
<213>  Homosapiens

<400>  3991

Met Ala Asp Arg Gly Cys Pro Leu Glu Ala Ala Pro Leu Pro Ala Glu 
1               5                   10                  15      


Val Arg Glu Ser Leu Ala Glu Leu Glu Leu Glu Leu Ser Glu Gly Asp 
            20                  25                  30          


Ile Thr Gln Lys Gly Tyr Glu Lys Lys Arg Ala Lys Leu Leu Ala Arg 
        35                  40                  45              


Tyr Ile Pro Leu Ile Gln Gly Ile Asp Pro Ser Leu Gln Ala Glu Asn 
    50                  55                  60                  


Arg Ile Pro Gly Pro Ser Gln Thr Thr Ala Ala Ala Pro Lys Gln Gln 
65                  70                  75                  80  


Lys Ser Arg Pro Thr Ala Ser Arg Asp Glu Arg Phe Arg Ser Asp Val 
                85                  90                  95      


His Thr Glu Ala Val Gln Ala Ala Leu Ala Lys Tyr Lys Glu Arg Lys 
            100                 105                 110         


Met Pro Met Pro Ser Lys Arg Arg Ser Val Leu Val His Ser Ser Val 
        115                 120                 125             


Glu Thr Tyr Thr Pro Pro Asp Thr Ser Ser Ala Ser Glu Asp Glu Gly 
    130                 135                 140                 


Ser Leu Arg Arg Pro Gly Arg Leu Thr Ser Thr Pro Leu Gln Ser His 
145                 150                 155                 160 


Ser Ser Val Glu Pro Trp Leu Asp Arg Val Ile Gln Gly Ser Ser Thr 
                165                 170                 175     


Ser Ser Ser Ala Ser Ser Thr Ser Ser His Pro Gly Gly Arg Pro Thr 
            180                 185                 190         


Thr Ala Pro Ser Ala Ala Ala Thr Pro Gly Ala Ala Ala Thr Thr Ala 
        195                 200                 205             


Leu Ala Gly Leu Glu Ala His Thr His Ile Asp Leu His Ser Ala Pro 
    210                 215                 220                 


Pro Asp Val Thr Thr Gly Leu Val Glu His Ser Tyr Phe Glu Arg Pro 
225                 230                 235                 240 


Gln Val Ala Ser Val Arg Ser Val Pro Arg Gly Cys Ser Gly Ser Met 
                245                 250                 255     


Leu Glu Thr Ala Asp Gly Val Pro Val Asn Ser Arg Val Ser Ser Lys 
            260                 265                 270         


Ile Gln Gln Leu Leu Asn Thr Leu Lys Arg Pro Lys Arg Pro Pro Leu 
        275                 280                 285             


Lys Glu Phe Phe Val Asp Asp Phe Glu Glu Leu Leu Glu Val Gln Gln 
    290                 295                 300                 


Pro Asp Pro Asn Gln Pro Lys Pro Glu Gly Ser Glu Thr Ser Val Leu 
305                 310                 315                 320 


Arg Gly Glu Pro Leu Thr Ala Gly Val Pro Arg Pro Pro Ser Leu Leu 
                325                 330                 335     


Ala Thr Leu Gln Arg Trp Gly Thr Thr Gln Pro Lys Ser Pro Cys Leu 
            340                 345                 350         


Thr Ala Leu Asp Thr Thr Gly Lys Ala Val Tyr Thr Leu Thr Tyr Gly 
        355                 360                 365             


Lys Leu Trp Ser Arg Ser Leu Lys Leu Ala Tyr Thr Leu Leu Asn Lys 
    370                 375                 380                 


Leu Thr Ser Lys Asn Glu Pro Leu Leu Lys Pro Gly Asp Arg Val Ala 
385                 390                 395                 400 


Leu Val Phe Pro Asn Ser Asp Pro Val Met Phe Met Val Ala Phe Tyr 
                405                 410                 415     


Gly Cys Leu Leu Ala Glu Leu Val Pro Val Pro Ile Glu Val Pro Leu 
            420                 425                 430         


Thr Arg Lys Asp Ala Gly Ser Gln Gln Val Gly Phe Leu Leu Gly Ser 
        435                 440                 445             


Cys Gly Val Phe Leu Ala Leu Thr Thr Asp Ala Cys Gln Lys Gly Leu 
    450                 455                 460                 


Pro Lys Ala Gln Thr Gly Glu Val Ala Ala Phe Lys Gly Trp Pro Pro 
465                 470                 475                 480 


Leu Ser Trp Leu Val Ile Asp Gly Lys His Leu Ala Lys Pro Pro Lys 
                485                 490                 495     


Asp Trp His Pro Leu Ala Gln Asp Thr Gly Thr Gly Thr Ala Tyr Ile 
            500                 505                 510         


Glu Tyr Lys Thr Ser Lys Glu Gly Ser Thr Val Gly Val Thr Val Ser 
        515                 520                 525             


His Ala Ser Leu Leu Ala Gln Cys Arg Ala Leu Thr Gln Ala Cys Gly 
    530                 535                 540                 


Tyr Ser Glu Ala Glu Thr Leu Thr Asn Val Leu Asp Phe Lys Arg Asp 
545                 550                 555                 560 


Ala Gly Leu Trp His Gly Val Leu Thr Ser Val Met Asn Arg Met His 
                565                 570                 575     


Val Val Ser Val Pro Tyr Ala Leu Met Lys Ala Asn Pro Leu Ser Trp 
            580                 585                 590         


Ile Gln Lys Val Cys Phe Tyr Lys Ala Arg Ala Ala Leu Val Lys Ser 
        595                 600                 605             


Arg Asp Met His Trp Ser Leu Leu Ala Gln Arg Gly Gln Arg Asp Val 
    610                 615                 620                 


Ser Leu Ser Ser Leu Arg Met Leu Ile Val Ala Asp Gly Ala Asn Pro 
625                 630                 635                 640 


Trp Ser Ile Ser Ser Cys Asp Ala Phe Leu Asn Val Phe Gln Ser Arg 
                645                 650                 655     


Gly Leu Arg Pro Glu Val Ile Cys Pro Cys Ala Ser Ser Pro Glu Ala 
            660                 665                 670         


Leu Thr Val Ala Ile Arg Arg Pro Pro Asp Leu Gly Gly Pro Pro Pro 
        675                 680                 685             


Arg Lys Ala Val Leu Ser Met Asn Gly Leu Ser Tyr Gly Val Ile Arg 
    690                 695                 700                 


Val Asp Thr Glu Glu Lys Leu Ser Val Leu Thr Val Gln Asp Val Gly 
705                 710                 715                 720 


Gln Val Met Pro Gly Ala Asn Val Cys Val Val Lys Leu Glu Gly Thr 
                725                 730                 735     


Pro Tyr Leu Cys Lys Thr Asp Glu Val Gly Glu Ile Cys Val Ser Ser 
            740                 745                 750         


Ser Ala Thr Gly Thr Ala Tyr Tyr Gly Leu Leu Gly Ile Thr Lys Asn 
        755                 760                 765             


Val Phe Glu Ala Val Pro Val Thr Thr Gly Gly Ala Pro Ile Phe Asp 
    770                 775                 780                 


Arg Pro Phe Thr Arg Thr Gly Leu Leu Gly Phe Ile Gly Pro Val Ser 
785                 790                 795                 800 


Met Ser Ser Cys Thr Ser Thr Gly Ser Gln Arg Arg 
                805                 810         


<210>  3992
<211>  1095
<212>  DNA
<213>  Homosapiens

<400>  3992
tgccgcccag gacccgcagc agagacgacg cctgcagcaa ggagaccagg aaggggtgag     60

acaaggaaga ggatgtctga gctggagaag gccatggtgg ccctcatcga cgttttccac    120

caatattctg gaagggaggg agacaagcac aagctgaaga aatccgaact caaggagctc    180

atcaacaatg agctttccca tttcttagag gaaatcaaag agcaggaggt tgtggacaaa    240

gtcatggaaa cactggacaa tgatggagac ggcgaatgtg acttccagga attcatggcc    300

tttgttgcca tggttactac tgcctgccac gagttctttg aacatgagtg agattagaaa    360

gcagccaaac ctttcctgta acagagacgg tcatgcaaga aagcagacag caagggcttg    420

cagcctagta ggagctgagc tttccagccg tgttgtagct aattaggaag cttgatttgc    480

tttgtgattg aaaaattgaa aacctctttc caaaggctgt tttaacggcc tgcatcattc    540

tttctgctat attaggcctg tgtgtaagct gactggcccc agggactctt gttaacagta    600

acttaggagt caggtctcag tgataaagcg tgcaccgtgc agcccgccat ggccgtgtag    660

accctaaccc ggagggaacc ctgactacag aaattacccc ggggcaccct taaaacttcc    720

actaccttta aaaaacaaag ccttatccag cattatttga aaacactgct gttctttaaa    780

tgcgttcctc atccatgcag ataacagctg gttggccggt gtggccctgc aagggcgtgg    840

tggcttcggc ctgcttcccg ggatgcgcct gatcaccagg tgaacgctca gcgctggcag    900

cgtcctggaa aaagcaactc catcagaact cgcaatccga gccagctctg ggggctccag    960

cgtggcctcc gtgacccatg cgattcaagt cgcggctgca ggatccttgc ctccaacgtg   1020

cctccagcac atgcggcttc cgagggcact accgggggct ctgagccacc gcgagggcct   1080

gcgttcaata aaaag                                                    1095


<210>  3993
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  3993

Met Ser Glu Leu Glu Lys Ala Met Val Ala Leu Ile Asp Val Phe His 
1               5                   10                  15      


Gln Tyr Ser Gly Arg Glu Gly Asp Lys His Lys Leu Lys Lys Ser Glu 
            20                  25                  30          


Leu Lys Glu Leu Ile Asn Asn Glu Leu Ser His Phe Leu Glu Glu Ile 
        35                  40                  45              


Lys Glu Gln Glu Val Val Asp Lys Val Met Glu Thr Leu Asp Asn Asp 
    50                  55                  60                  


Gly Asp Gly Glu Cys Asp Phe Gln Glu Phe Met Ala Phe Val Ala Met 
65                  70                  75                  80  


Val Thr Thr Ala Cys His Glu Phe Phe Glu His Glu 
                85                  90          


<210>  3994
<211>  641
<212>  DNA
<213>  Homosapiens

<400>  3994
gagtcagagc tctgcatgtc tgcaccatgt cctgggctcc tgtcctgctc atgctgtttg     60

tctactgcac aggttgtggt cctcagccgg tgctgcatca gccgccggcc atgtcctcgg    120

cccttggaac cacaatccgc ctcacctgca ccctgaggaa cgaccatgac atcggtgtgt    180

acagcgtcta ctggtaccag cagaggccgg gccaccctcc caggttcctg ctgagatatt    240

tctcacaatc agacaagagc cagggccccc aggtcccccc tcgcttctct ggatccaaag    300

atgtggccag gaacaggggg tatttgagca tctctgagct gcagcctgag gacgaggcta    360

tgtattactg tgctatgggg gcccgcagct cggagaagga ggagagggag agggagtggg    420

aggaagaaat ggaacccact gcagccagga cacgtgtccc ttgaactgaa gacagcagag    480

gcacgcatcc ccttggagag actgtcatgg aagagggtgg agccgccgcc cgaagcgccg    540

aggaggctga gccactcagc atctcctggt cctgcagtgt tgctgtaaat ccccattgga    600

gactgcatta gggaattaaa gctgcttgtc actttttgct g                        641


<210>  3995
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  3995

Met Ser Trp Ala Pro Val Leu Leu Met Leu Phe Val Tyr Cys Thr Gly 
1               5                   10                  15      


Cys Gly Pro Gln Pro Val Leu His Gln Pro Pro Ala Met Ser Ser Ala 
            20                  25                  30          


Leu Gly Thr Thr Ile Arg Leu Thr Cys Thr Leu Arg Asn Asp His Asp 
        35                  40                  45              


Ile Gly Val Tyr Ser Val Tyr Trp Tyr Gln Gln Arg Pro Gly His Pro 
    50                  55                  60                  


Pro Arg Phe Leu Leu Arg Tyr Phe Ser Gln Ser Asp Lys Ser Gln Gly 
65                  70                  75                  80  


Pro Gln Val Pro Pro Arg Phe Ser Gly Ser Lys Asp Val Ala Arg Asn 
                85                  90                  95      


Arg Gly Tyr Leu Ser Ile Ser Glu Leu Gln Pro Glu Asp Glu Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Met Gly Ala Arg Ser Ser Glu Lys Glu Glu Arg Glu 
        115                 120                 125             


Arg Glu Trp Glu Glu Glu Met Glu Pro Thr Ala Ala Arg Thr Arg Val 
    130                 135                 140                 


Pro 
145 


<210>  3996
<211>  702
<212>  DNA
<213>  Homosapiens

<400>  3996
aggagctcta cggtgacttt gaagacttgg aaacagggga cgtgcacaag ggaaaatcgg     60

gccccgatac tcagaatgaa gatgtagaga aacaaggaag aaattgaccc tgacgaagaa    120

gaaagtgcca agaaaaagca tttggataag aagagaaaat tgaaggagat gtttgatgtg    180

gaatatgatg aaggagaaag cacatatttt gatgatctta aaggagaaat gcagaaacaa    240

gcacagctga atcatgcaga atttgaagat caagatgatg aagccagagt tcagtatgag    300

ggttttcgac ctgggatgta cgtctgcgtt gagattgaaa atgttccctg tgaatttgtg    360

tagaactttg acccccgtta ccccattatc ctgggtggct tgggcaacag cgagggaaat    420

gttggatacg tgcagatgcg tctgaagaaa catcgctggt ataagaaaat cctcaagtcc    480

cgagatccaa tcatattttc tgtagggtgg aggaggtttc agaccatccc gctctgttat    540

atcgaagacc acaatggaag acaaaggctt ctaaagtata ccccacagca tgtgcatcgc    600

ggagcagcct tttgggatcc tatcactcca cagggaactg gtttcttggc aatacagtct    660

gtcagtggca taatgcctga ttttcggata gctgccacat aa                       702


<210>  3997
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  3997

Met Arg Leu Lys Lys His Arg Trp Tyr Lys Lys Ile Leu Lys Ser Arg 
1               5                   10                  15      


Asp Pro Ile Ile Phe Ser Val Gly Trp Arg Arg Phe Gln Thr Ile Pro 
            20                  25                  30          


Leu Cys Tyr Ile Glu Asp His Asn Gly Arg Gln Arg Leu Leu Lys Tyr 
        35                  40                  45              


Thr Pro Gln His Val His Arg Gly Ala Ala Phe Trp Asp Pro Ile Thr 
    50                  55                  60                  


Pro Gln Gly Thr Gly Phe Leu Ala Ile Gln Ser Val Ser Gly Ile Met 
65                  70                  75                  80  


Pro Asp Phe Arg Ile Ala Ala Thr 
                85              


<210>  3998
<211>  5733
<212>  DNA
<213>  Homosapiens

<400>  3998
aattataaca gctggccttc tggtgggcaa accatcccct gatggactgg aagcctaccc     60

cccaccccaa gccctggctg cgacagctct ggaaccctga ctgcctgggt gcccctcagc    120

tctggaaccc tgactgcctg gatgctcctc agctctggaa ccctgactgc ttggataccc    180

cctcagctct ggaaccctga ctgcctggaa ccgtgatccg gaacccaaga tcctttcaag    240

gcctcagggg tattgctgct gccctcctcc ttctcaattt aaccccgcgt ccagccgtcg    300

ccaccagggg cgtcagagcg cgcgcatgct cctagctcgg agccgcgccg atctcgcgcc    360

ggcacctggc agccaatcgc aggtctccac tggacgcgcg cgtgtggagg cgtgcgcgtc    420

ggcggcgccg ggggcctgag gaggcgtagt cgccgccggc tgtgccccgg gagcgcctcc    480

ggggctggtg cgtggccggc agctcgcgaa cagcagctga tccggactgg atgtgacctt    540

ctgcctggaa tagctcaagt tcttaaaagt tgcgttgtaa taaacctgag gctgggaagt    600

tcaagatcaa gatgctggac gatttggttc cttagtgaag gctctcttcc tggctggtgg    660

atgacagcct tcttgctgtg ttctcacatg acagaaagag gaagcaaggt ggcagtttat    720

ataaaggaag cattgggact tgtggcccca ccattcagga ataaaaaaat tagaaaatgg    780

aacaatcatg tgaggaagag aaagagcctg aaccacagaa gaacatacaa gaaaccaaac    840

aagtagatga cgaagatgct gagctcatct ttgttggtgt ggaacatgta aatgaagatg    900

ctgagctaat ctttgttggg gtgacttcaa attcaaaacc agtcgtttca aacattttga    960

acagagtcac cccgggttca tggtcaagga gaaaaaagta tgatcacctt agaaaagata   1020

ctgctcgcaa attgcagcct aaaagtcatg agaccgttac atcagaagca gtgaccgtcc   1080

tgccagcttc ccaacttgaa tcgagatcaa cagatagtcc tattattatt gagcctttgt   1140

ctaaacctga ttatagaaat agttcaccac aagttgtgcc taataactct tcagaattac   1200

cttctccttt gattacattc acagattcat tgcatcatcc agtaagtaca gcactttcag   1260

taggaggtat aaatgaaagt cctcgtgtat caaagcaact ttccactttc gaagtaaaca   1320

gcataaatcc caaaagggct aaactcaggg atggaattat agaaggaaat tcttcagctt   1380

cgttcccttc agataccttt catacaatga atactcagca aagtacaccc tcaaataatg   1440

ttcatacctc attaagccat gttcagaatg gagcaccttt tccagcagct tttccaaagg   1500

acaatatcca tttcaagcct ataaatacaa atcttgatag ggaaaatgaa ttggcaaaaa   1560

cagacatttt gagtctaaca agtcaaaaca agacctttga tcccaagaaa gaaaatccca   1620

ttgtgttact tagtgacttt tactatggac agcataaagg agaagggcag ccggaacaga   1680

agactcacac cacctttaaa tgcctcagct gcgtgaaagt tctaaaaaat gttaagttta   1740

tgaatcacgt gaagcatcat ttggaatttg agaagcagag gaacgacagc tgggaaaacc   1800

acaccacctg ccagcactgc caccggcagt ttcccactcc cttccagcta cagtgtcaca   1860

tcgaaaatgt ccacactgcc caggagccct ctactgtctg taaaatctgt gaattgtcat   1920

ttgaaacaga tcaggtcctc ttacaacaca tgaaggacca tcataagcct ggcgaaatgc   1980

cctatgtgtg ccaggtttgc cattatagat cgtcggtctt tgctgatgta gaaacacatt   2040

ttagaacgtg ccatgaaaac acaaagaatt tgctttgtcc cttttgtctc aaaattttca   2100

aaacagcaac accatacatg tgtcattata ggggccactg gggaaagagt gcacaccagt   2160

gttccaagtg ccggctacag tttttaactt tcaaggagaa aatggagcac aagacccagt   2220

gtcatcaaat gtttaagaag cctaagcaac tagaaggatt acctcctgaa acaaaagtta   2280

ctattcaagt gtcactggaa cctcttcagc caggatcagt ggatgtagca tccataactg   2340

tgagcacatc tgactctgaa ccatcactcc ccaggtctaa aagcaaaatt tcaaaaaagt   2400

cccattaatt ctagtttcag taaatctaaa gcaagtattt caaaccaaat taaaaaacct   2460

cataaaacaa aaaatacaaa ccatacatta ttcagtagca ccaaaaatag tgaaactagt   2520

ggattatata tgacttttta aacaagattc aggatatata ttatttgatc tgaattttga   2580

ggtattattt taaaacatct ggttttcatg ttaactgtat ctggcttaac acataaaagg   2640

tgtttgtgtg tgtgtgtgtg agagagaaag gtattaattt atttttttaa ttttaatttt   2700

tttttttttt actttagaga cagggtctca ctgttaccca ggctggagtg cagtggcgtg   2760

atcctagctc actgcaacct tgaacttcca ggctcaagca ttcctccgcc tcagcctttg   2820

gagagtagct aggactacag gcgcagccac cacacccagc tagtttttta ttttaatttt   2880

ttgtagcgat ggaatcttgt tatgtcgccc agggtggtct cgaactcctg accttagggg   2940

agcctcctgc ctcagcctcc ccaagtgctg ggttgtgtga gtcactgccc ctggcaccta   3000

tttattgttt tggtatttca tgttactcct aagcttgaaa gctctttttt ctatatacag   3060

aattcataga atttttgaaa tacttagttt tctttacagc tttttccatg cattcagcat   3120

ttcatggtta actctagtca gactggaatg gctttgttat gccctggccc acttgctgcc   3180

gaattcccag aagtgcctct gctgtgctgg cataaaataa cctgaaaaga ttctgaaaag   3240

ccaggatgtg gaattgaaag agaagctgct gcgtgagcag agaccaagaa ggcggaggtt   3300

agttgaggga gagcagtggt tctttgttct agttgaagga taggcacaca ttcattctag   3360

tcttggggcc aggtcaaaag gaacactgct tcagagtatc tttacctacc tgaaaacatc   3420

caaggaagcc aaaccattca aagtaaaatg gttttgtttg gtgaagggcc cctgcagaca   3480

tcaaacagcc gtcatgtatc attggtttga ggtgaaatag caataaaatt aatagaatgg   3540

tgcctggtac tagctgactt cctgttctgt gatctaaagg tgaatttgat tcattccctc   3600

tcctctccct tctggctagc cgttagtgga gaatgaactg gccatattct cagccacagc   3660

tgtaaagcaa gtttcccaag gggaagaagc cctaatatct ataatttgaa ctgtactgga   3720

cccatagttt taactgaaaa gggccaaaca agtggtgtct gtccagttcc tggactgggc   3780

taaatttagt tttcccactg ttaagctgga atgaggactg tcccaacaac agtaggtaca   3840

gtggacaaaa atagcccagg gtgactgact gaatttaaac ccataatggc tttatatttt   3900

tctgtgcata tatatcttac cctaattgaa catgtgaagc ttgcaacttt atgtcttgct   3960

ttggacatga atgtattaca gcttgcagct attctgttaa atgtatagtt tcccagtttt   4020

ttgacactaa tgctgtttgg gtcttacctg acacacacca gtgtgcaaga aatgtctctc   4080

taattcaata agttttaaga cttagagtta atgtccttca tctgatctat cctatctaat   4140

ctgtactatg ggtgaatctt tttcccttgc tctccccagg ggctgtttca cagtattctg   4200

gagtaccttt tgagtattgg ttcctgaaca tcagcagtct tggctgcctc tgtggactcc   4260

cggagttgtc tccctgcttg tgttctggtg ccatcctttg ttcctccacc cctgaccaag   4320

gtgcccagca gcctgtcttc accagtcaag gaatccgcca tcttggctgt agacataggt   4380

ctggagaaat ctctcccttt ttccttgatt tctttttaaa ggtaccttat ctctccccac   4440

tcctttcttc cctcctcaat ctagttaaat ttcctaagct ttcacaaaaa tccgggaaga   4500

gataattaag agcttagcat ccctcttaga gtagaaggca gtacagataa caaagaagtt   4560

gtgagtatat tatctacatt ttagaaaatt ttctgactct agatccatag attctgttgt   4620

atttatttgc cggacactca tttgattgat ttgcaccttg aacactatac taggtctttt   4680

cagttacgtt gcttgggtta agacactttg ctaaaattac agcctgaatc ctttctttag   4740

ttgaagaaag ggtatgtgtg tgcaagtggg tgtgtgtgtg ccagtttttc ttgtctcagg   4800

tagatactcc cactgtgtat aaatagatct acagactttt catacttacc tcccgtattc   4860

tgtttctgtg gtaaaaatat gaagtgtttt agttgtatgt tgagtgattg gttggtatta   4920

tcaacactgt tgtttgcagt ttcattaaag catgctctta aggagtacat atggtcatta   4980

attgccaact gtagattcca gtgatctggc ccctgcctac ctccttcctc tctttttcat   5040

tctctgtcat gcttctccac tgttttcccc aatgacgcac tattttgaca cactggcctt   5100

gctattcctt aagcaaatca cattcttccc aatccaaaga ctttgcacat gctgttgtct   5160

ttcttagaat gcccttcccc taggcctgca tggcttgcta cctcacttaa ttgtttgaca   5220

cttcctttgg ttcattgagc ttcaaggctc ttaaaatgcc actgacaatg agatctccct   5280

ttaaaaaaaa aaaaaaactt ctacttttcc tcttaaaggc actttactct ctccccactc   5340

ttttcttcct cttcaaagta tttaaatttc ctaggttttc atgaaaaagc tggaaagcga   5400

tcagcatcaa gggctttgct tctgtcttag aattgagcta gcttgagtca atttctgtgc   5460

ctgcaaccaa atgaaaatta atatagtgag ttctttcagg agctttctct gtttttctat   5520

tgatacctct atatattttt aaggcaatgt cactttgttt tgtttacaaa tatattgaat   5580

atgtcaagat tactattttg ttattgccct ttgtgaattt ccttgtctat tttgctcgct   5640

tgttctttca ggtgaaattt attattttat taatgttgcc aaaaattata agtaaaatat   5700

caattatagt aataaaatgt tttgtgaaaa aaa                                5733


<210>  3999
<211>  543
<212>  PRT
<213>  Homosapiens

<400>  3999

Met Glu Gln Ser Cys Glu Glu Glu Lys Glu Pro Glu Pro Gln Lys Asn 
1               5                   10                  15      


Ile Gln Glu Thr Lys Gln Val Asp Asp Glu Asp Ala Glu Leu Ile Phe 
            20                  25                  30          


Val Gly Val Glu His Val Asn Glu Asp Ala Glu Leu Ile Phe Val Gly 
        35                  40                  45              


Val Thr Ser Asn Ser Lys Pro Val Val Ser Asn Ile Leu Asn Arg Val 
    50                  55                  60                  


Thr Pro Gly Ser Trp Ser Arg Arg Lys Lys Tyr Asp His Leu Arg Lys 
65                  70                  75                  80  


Asp Thr Ala Arg Lys Leu Gln Pro Lys Ser His Glu Thr Val Thr Ser 
                85                  90                  95      


Glu Ala Val Thr Val Leu Pro Ala Ser Gln Leu Glu Ser Arg Ser Thr 
            100                 105                 110         


Asp Ser Pro Ile Ile Ile Glu Pro Leu Ser Lys Pro Asp Tyr Arg Asn 
        115                 120                 125             


Ser Ser Pro Gln Val Val Pro Asn Asn Ser Ser Glu Leu Pro Ser Pro 
    130                 135                 140                 


Leu Ile Thr Phe Thr Asp Ser Leu His His Pro Val Ser Thr Ala Leu 
145                 150                 155                 160 


Ser Val Gly Gly Ile Asn Glu Ser Pro Arg Val Ser Lys Gln Leu Ser 
                165                 170                 175     


Thr Phe Glu Val Asn Ser Ile Asn Pro Lys Arg Ala Lys Leu Arg Asp 
            180                 185                 190         


Gly Ile Ile Glu Gly Asn Ser Ser Ala Ser Phe Pro Ser Asp Thr Phe 
        195                 200                 205             


His Thr Met Asn Thr Gln Gln Ser Thr Pro Ser Asn Asn Val His Thr 
    210                 215                 220                 


Ser Leu Ser His Val Gln Asn Gly Ala Pro Phe Pro Ala Ala Phe Pro 
225                 230                 235                 240 


Lys Asp Asn Ile His Phe Lys Pro Ile Asn Thr Asn Leu Asp Arg Glu 
                245                 250                 255     


Asn Glu Leu Ala Lys Thr Asp Ile Leu Ser Leu Thr Ser Gln Asn Lys 
            260                 265                 270         


Thr Phe Asp Pro Lys Lys Glu Asn Pro Ile Val Leu Leu Ser Asp Phe 
        275                 280                 285             


Tyr Tyr Gly Gln His Lys Gly Glu Gly Gln Pro Glu Gln Lys Thr His 
    290                 295                 300                 


Thr Thr Phe Lys Cys Leu Ser Cys Val Lys Val Leu Lys Asn Val Lys 
305                 310                 315                 320 


Phe Met Asn His Val Lys His His Leu Glu Phe Glu Lys Gln Arg Asn 
                325                 330                 335     


Asp Ser Trp Glu Asn His Thr Thr Cys Gln His Cys His Arg Gln Phe 
            340                 345                 350         


Pro Thr Pro Phe Gln Leu Gln Cys His Ile Glu Asn Val His Thr Ala 
        355                 360                 365             


Gln Glu Pro Ser Thr Val Cys Lys Ile Cys Glu Leu Ser Phe Glu Thr 
    370                 375                 380                 


Asp Gln Val Leu Leu Gln His Met Lys Asp His His Lys Pro Gly Glu 
385                 390                 395                 400 


Met Pro Tyr Val Cys Gln Val Cys His Tyr Arg Ser Ser Val Phe Ala 
                405                 410                 415     


Asp Val Glu Thr His Phe Arg Thr Cys His Glu Asn Thr Lys Asn Leu 
            420                 425                 430         


Leu Cys Pro Phe Cys Leu Lys Ile Phe Lys Thr Ala Thr Pro Tyr Met 
        435                 440                 445             


Cys His Tyr Arg Gly His Trp Gly Lys Ser Ala His Gln Cys Ser Lys 
    450                 455                 460                 


Cys Arg Leu Gln Phe Leu Thr Phe Lys Glu Lys Met Glu His Lys Thr 
465                 470                 475                 480 


Gln Cys His Gln Met Phe Lys Lys Pro Lys Gln Leu Glu Gly Leu Pro 
                485                 490                 495     


Pro Glu Thr Lys Val Thr Ile Gln Val Ser Leu Glu Pro Leu Gln Pro 
            500                 505                 510         


Gly Ser Val Asp Val Ala Ser Ile Thr Val Ser Thr Ser Asp Ser Glu 
        515                 520                 525             


Pro Ser Leu Pro Arg Ser Lys Ser Lys Ile Ser Lys Lys Ser His 
    530                 535                 540             


<210>  4000
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  4000
atggccacgc gggtcgaggt gggctccata acgcccttga cggccgtgcc aggcctgggt     60

gagatgggca aggaggagac cctgacgagg acctacttcc tccaggccgg cgaagcctct    120

ggggctcccc cagcccggat cttggaagcg aagagccccc tgcggagccc ggcccggtta    180

ctccctctgc caaggctcgc ccccaaaccc ttctcgaagg agcaggacgt gaaatctcct    240

gtcccgtctc tgcggcccag ttcgactgga ccttccccct ctggggggct ctctgaggag    300

ccagcagcaa aggatctgga caacaggatg cccggcttgg tggggcagga ggtgggcagt    360

ggggagggcc cgaggacgag ctcgcccctc ttcaacaagg ctgtgttcct gcggcccagc    420

tccagcacca tgattctctt cgaaaccacc aaaagcggcc ccgctctggg gaaggcggtt    480

agtgaggggg cggaggaggc caagctaggt gtgtccggct cccggcctga ggtggctgcc    540

aagcccgccc tgcccaccca gaagcctgcg gggacccttc cccggtcagc tcccctgtct    600

caggacacaa aaccacctgt accccaagag gaggcaggcc aagaccatcc tccctcaaag    660

gccagcagtg tggaggacac ggcacgcccc cttgtggagc ccaggcctcg cctgaagaga    720

aggcccgtgt ctgccatttt cacggagtcc attcagcctc agaagccagg ccccggcgca    780

gcggccacag tgggcaaagt gccacccacc cctcccgaga agacgtgggt gaggaagccc    840

aggcccttgt ccatggacct cacggcccgg tttgagaaca aagaggcctt gctgaggaag    900

gtggccgatg aaggaagtgg acccacagca ggggatatgg ctgggctaga gaggcccaga    960

gcagcgtcca agctggacag ggactgtttg gtcaaggcgg aggctcctct tcatgatcct   1020

gatttggact tcctggaggt ggccaagaaa atccgtgaac ggaaggagaa gatgctttcg   1080

aagccggaga tgggcagccc cagagccctg gtggggggct catctggggt cacccccagc   1140

aatgaccaga gtccctggga agaaaaggcc aagctggacc cagagccaga gaaggctgct   1200

gagtccccct cacccaggct gggaaggggc ctagaacttg ctgaggttaa gagcagagtg   1260

gcggatgggg aggccgcggc agggggagag tgggcctcca ggaggagtgt caggaagtgc   1320

atcagcctgt ttcgggagga cagcaccttg gccttggcag tggggtctga atctcccctg   1380

gccacccctg cgtccccatc ggcggcacca gagccggaga aaggggttgt gagcgttcag   1440

gaacggatca gaggctggac tgccgagagc tcagaggcta agcccgaggt caggaggagg   1500

acgttccagg ctcggccgct gtcggcggat ttgaccaaat tgttttcaag ttcagcttcc   1560

agcaacgaag tcaaatatga gaagagtgct gagctgagcg gcgagtttcc taaggaaccg   1620

agagaaaagc aaaaggaggg gcacagtttg gatggagcat gcatcccgag aagcccctgg   1680

aagcctggga cactccggga taagtccagg cagacggagc agaaggttag ctctaaccaa   1740

gaccccgaca gctgtcgcgg tggaagctca gtggaggccc cgtgcccttc tgacgtcact   1800

ccagaggatg accggagctt ccagactgtg tgggccacag tatttgagca ccacgtggag   1860

agacacacag tggctgacca gtcgggacgt tgtctctcca ccacaccccc tggtgacatg   1920

gcccatgccc gtgtctcaga acccaggccg aggcctgaga tgggctcttg gctgggcagg   1980

gacccaccag acatgacaaa actgaagaaa gagaactcca gagggtttga caatcccgag   2040

acggagaaat tgggaccaac cacccttttg aatggtgaac tgagaccgta tcacacgcct   2100

ctccgggaca aatacccttt gtctgaaaac cacaataata acaccttcct caaacacttg   2160

gaaaatcctc ccacatcgca gagaattgag cccagatatg acattgtgca tgcagtggga   2220

gagcgtgtgc acagcgaggc catctcaccg gcaccggagg agaaagcggt cacgctccgc   2280

agcctcaggt cttggctctc actgaaggac aggcagctgt cccaggaggt cacccctgct   2340

gacctggagt gtggtttgga aggtcaggcg gggtccgtcc aaagggccag tttgatttgg   2400

gaagctcgag gcatgcctga ggctagtgga ccgaagtttg ggggcaattg cccgtttccc   2460

aaatggacag gcggggcagt ggtgagctcg cacaaagcca ccgtggcagt cagcgaagag   2520

cactgtgctc ccggggccac ctccgtcagg gctatcaagg ctgccatctg ggaaagccag   2580

catgaggggc cagagggggc cagaagcaag ccaggagtgg gagcaagggg cccaccccag   2640

ggatgccccc tcgatcctct ttccagggct acgaatgggc cttctgactc ccaagcacga   2700

acacatccag atgcatttgc tgtgcagaaa gggcccttca ttgtagccgc cagggagggt   2760

gatccagggc cggcccaggt gccacagcct gcagtcagaa tgcggaaagc cggcgccatg   2820

gaccagagaa tggacagatg gcggcggcgg actttacccc ccaacgtgaa atttgataca   2880

ttcagttctc ttgtcccaga ggactctcca catgtggggc acagacgaac agattatgtg   2940

agccccacag ccagtgcctt aagaaaacct caactatccc actacagggt ggagacccag   3000

gaggtgaacc caggtgcttc acgggaccag acttccccag cagtgaagca agggtcacct   3060

gtggaaccca aggcgacatt ttttgcagtc acctatcaga ttcccaatac tcaaaaggca   3120

aagggtgtgg ttctgtcagg agctgaaagc ttgctggaac attctagaaa aatcactcca   3180

ccctcgtctc ctcattcttt aacatccact ttggtttctc ttggtcatga agaggcattg   3240

gagatggcag gcagtaaaaa ctggatgaag ggacgagagc atgaaaatgc aagcatttta   3300

aaaactctga agccaacaga ccgtccatca tctcttgggg cctggagtct ggaccctttc   3360

aatggaagaa tcattgatgt ggatgcctta tggagtcatc ggggatcaga agatggccct   3420

cgtcctcaaa gcaattggaa ggaaagtgcg aacaagatgt cccccagcgg cggagctccc   3480

caaaccaccc cgactctgag gagtcgtcca aaagatcttc ctgtgagaag gaagactgat   3540

gtgatcagtg acacgttccc aggtaaaatc agagatggct acagatccag cgttcttgac   3600

attgacgccc tgatggcaga gtaccaggag ctgtcgctga aagtccctgg ggaggctcag   3660

gagaggagga gtcccaccgt ggagcccagt acgttgcctc gggagaggcc tgttcagctg   3720

ggcggggtgg agcagagaag gaggagcctg aaggagatgc ccgataccgg gggtctctgg   3780

aaaccggcca gttctgccga aataaatcac agtttcactc ctggcttagg caagcagctg   3840

gcagagacct tggagacagc catgggcacc aaatctagcc ctcccttctg ggctctgcca   3900

ccctcggctc cttctgaaag gtatccaggg ggctctccta tacctgcgga tcccaggaaa   3960

aaaacggggt ttgctgagga tgacagaaag gcctttgcca gtaaacatca tgttgcaaag   4020

tgtcagaatt acctggctga gtcaaagccc tctggtcggg aggatccagg cagtggggtc   4080

agggtgtcac ccaaatcgcc ccccactgac cagaagaaag ggaccccaag gaaatccacc   4140

gggcggggag aggaggacag tgtggcccag tggggtgacc acccacgtga ctgtggacgg   4200

gtgccgctgg atatcaagag ggcctactca gagaaggggc cccctgccaa catccgagag   4260

ggcctgtcca tcatgcatga agccagagag aggaggcgag agcagcccaa agggaggccc   4320

agccttactg gagagaattt ggaggccaaa atgggaccct gttggtggga gtcagggact   4380

ggagacagtc acaaggtgct gccacgggac ctggagaagg aggatgcccc ccaggagaag   4440

gagcgaccgc tccagcaggt gtcccctgtg gcctcggttc cctggagaag ccacagcttc   4500

tgcaaagaca ggaggagtgg gccctttgtg agggtgcctg ggacctgcca ggccaatgcc   4560

ctgctgattt gcatagccct gcccatggtt gctgaactac agaccctgcc acttgctaga   4620

ggccttgagc aaggttcccc tcaggacctc gagtccacat ggcgaatcca agtcctgtat   4680

caggcttcct ccctctcctc ttttccccag gaattagcgg ggcctaaccc cagacttgac   4740

actcatcagc cagtcagcca ggacacgcag cgccaggggt acagccaggc agctggcatc   4800

atccctccag cggtgccgcc agtgcagagg aaccagccct tttgctgcac ttttgtcggt   4860

cagcaggacc cagtgctctg gctatgctgt cagctggggc tgtcctctga ctggtactgt   4920

cagctgtgga gccgactggc tggtcccctg gccgtgagcc ggcttctgaa tgatttatgc   4980

cgccttgaac ttgactccag cgtgacagga gtgagaagag ccgctcccgc tagaggaaag   5040

ctggaaaccg tactgtgctc accacataac ctctgggtgc tggaaatgga gtattactac   5100

tgccccagcc tgctgaagct cttgcgctac ctctgggacc agctgaagca gtgtttctcc   5160

cggcagccca ctgaacccaa ggacactgac accctcgtgc acgaagccgg cagccagtat   5220

gggacgtgga cagagcagtg ccagagtggg gagagcttgg ccactgagtc cccagatagc   5280

agtgccacat cgacaaggaa acagcccccc agcagccgtt tgtcttctct gtcctcccaa   5340

acggagccca cctcggcagg ggaccagtat gactgctcca gggaccagcg gagcaccagc   5400

gtggaccact ccagcactga cctggaatcc accgatggga tggaggggcc gcctccaccg   5460

gacgcctgcc ctgaaaagag agtagatgac ttctccttca ttgatcaaac ctcagtcctc   5520

gactcaagtg ccctcaagac ccgggtgcag ctcagcaaga gaagccgccg ccgggccccc   5580

atctcccact ccctccggcg cagccgattt agtgagtccg agagcagatc acctttggag   5640

gatgagactg acaacacgtg gatgttcaaa gactcaacgg aggagaaatc acccaggaag   5700

gaggagtcgg atgaggagga gacggcatcc aaagctgaga ggacccctgt cagccatcct   5760

cagaggatgc ctgcgtttcc aggcatggat ccggcagtgc taaaggctca gctgcacaag   5820

aggccagagg tggacagtcc tggcgagacc cccagctggg caccccaacc caagagcccc   5880

aagtccccct tccagcctgg ggtgctgggc agtcgcgtgc tgccttccag catggacaag   5940

gatgagaggt cggatgaacc ctctccccag tggctaaagg aattgaaatc caagaagagg   6000

caaagtcttt atgagaacca agtttgacca ggcagggaac actgccacat ctacgtaaca   6060

gaagccttaa ccatcagaac ccgcagacga ggccgagctg ctgccgtttc ttcctgcaca   6120

acgcttacgt gcctgggccc ttcccattgg attgagaacg ctatccagtg cccctgtcct   6180

cgccaggctc tccctggatc cagacgggaa gacccaacct ccaggagcac tcgctcatct   6240

ccccagacag cacttcaggc tgggaaagga gccaggctgc ccagaaacgt ccatgtgggt   6300

ggttttgctt tttatgtaaa aatttgcatt tctacctatt ttagacacct tcatcagctc   6360

caagaacatc agtgtgaggc tggaattgtc tccccaggtt ctgaaaaaca cctgcatttg   6420

tgaaagcacc tcctcacccg accccggggc aggtcttttt ttggaaggac atttccaagg   6480

aagatcaaac tgttcatttt ctgctgtagt ctcggtgcag ggtattaccg ctgggttgag   6540

gttttctatt cttttttttt ggtgagttcc ttcttcccct tgaggaatca gcagttccaa   6600

tttttaaaca tactctccct gattatgtgt atttctcttt ctagtggggc tgtgtgcatc   6660

gttggcctat gttattgtat gtcatttttg tttgctttag aaggcgataa agcaataatt   6720

cagctaattt tctttgaaac ttgataggta tatatgtgtt tacgttaaag gacaggagga   6780

aagatgtgcg aataatttgt tctgaagtat ccagtcacct caggttatct tatccctatc   6840

caagctgttt agaagttata attgtcactc ttgtatttat ttccatggct tcttttcatt   6900

tgagctctgg tttcggtagg gtgacctttg ccccttggcc ttaagggttc ataaactgca   6960

gcccaagtgg tggtgccttt gcttatgaat catcagacct gccctagtaa tctttttctc   7020

cagagtcttc tttgaacatg acgtgggctg ctggcatgga ggagttgttc caaactggcc   7080

tcagaacaga tgcatgaatg aagggtactt tttgcttttg ctcacctcat tttccttcat   7140

ctttcttgat gaatccatta tttgcaaatg ctgtcaaaac atgctttcct tctccctggc   7200

tacctctcag gagttcattt gtctctctgt ctcagcttcc tccctcatct tcctttaccc   7260

ctcttctctg tcttagtggg tggatgggca tggatagaaa tcctctgttt ctttaggtta   7320

ggataaacac ctgggccctg gtgaggcagt tgctgttcag caccagggac agcaactgca   7380

gggctgtgag gccggagccc accttgtgtc ctgttcgatg agctttggtt actgatgagc   7440

aattgccaga tcatgtcacc cacccagcct tttacacctg ggagcctcat gcatctgggt   7500

ttgggagttt ggccctgctg atgatagttt gttttctctt cattccctga attagtcatc   7560

agttctccgt ggccatttgg ggattcatgc ctgcaactgc ttcagtcgaa ttctttttta   7620

aagatccagt ttatgtttta taataatttt gatcttatgg ctttcaacgt caataggatc   7680

ccctttaaaa ataccctgct agtgttttgt tttgttttgt ttttctgaga caaggtctta   7740

ctctgttgct caagctggag tggagtggca cgatcatagc tcactaacac ctgggctcaa   7800

gtgattctcc cacctcagcc tcccaagtag ctgggactac aggtgtatgc taccatgacc   7860

agctaatttt taaatatttt tgtagagaca agggtcttac catgttgccc aggctggtct   7920

cgaacttctg ggctcaagca attgtccctc ctcagcctcc caaagtgctc ggattacaga   7980

catgagccac tgcacctggc ctgaaacaca ttcctagtct tttgatcctg acttcttatc   8040

tgggctgctg tctctctttc cttcaggtgg aaaggacccc ttggtaccat ctcaagcagt   8100

aggaaaggac ctgctcttac atatattgat ggtcctcatg caaaactctc aattcttaat   8160

tagtcatgtc tcagctcaag gatatcagac ag                                 8192


<210>  4001
<211>  2008
<212>  PRT
<213>  Homosapiens

<400>  4001

Met Ala Thr Arg Val Glu Val Gly Ser Ile Thr Pro Leu Thr Ala Val 
1               5                   10                  15      


Pro Gly Leu Gly Glu Met Gly Lys Glu Glu Thr Leu Thr Arg Thr Tyr 
            20                  25                  30          


Phe Leu Gln Ala Gly Glu Ala Ser Gly Ala Pro Pro Ala Arg Ile Leu 
        35                  40                  45              


Glu Ala Lys Ser Pro Leu Arg Ser Pro Ala Arg Leu Leu Pro Leu Pro 
    50                  55                  60                  


Arg Leu Ala Pro Lys Pro Phe Ser Lys Glu Gln Asp Val Lys Ser Pro 
65                  70                  75                  80  


Val Pro Ser Leu Arg Pro Ser Ser Thr Gly Pro Ser Pro Ser Gly Gly 
                85                  90                  95      


Leu Ser Glu Glu Pro Ala Ala Lys Asp Leu Asp Asn Arg Met Pro Gly 
            100                 105                 110         


Leu Val Gly Gln Glu Val Gly Ser Gly Glu Gly Pro Arg Thr Ser Ser 
        115                 120                 125             


Pro Leu Phe Asn Lys Ala Val Phe Leu Arg Pro Ser Ser Ser Thr Met 
    130                 135                 140                 


Ile Leu Phe Glu Thr Thr Lys Ser Gly Pro Ala Leu Gly Lys Ala Val 
145                 150                 155                 160 


Ser Glu Gly Ala Glu Glu Ala Lys Leu Gly Val Ser Gly Ser Arg Pro 
                165                 170                 175     


Glu Val Ala Ala Lys Pro Ala Leu Pro Thr Gln Lys Pro Ala Gly Thr 
            180                 185                 190         


Leu Pro Arg Ser Ala Pro Leu Ser Gln Asp Thr Lys Pro Pro Val Pro 
        195                 200                 205             


Gln Glu Glu Ala Gly Gln Asp His Pro Pro Ser Lys Ala Ser Ser Val 
    210                 215                 220                 


Glu Asp Thr Ala Arg Pro Leu Val Glu Pro Arg Pro Arg Leu Lys Arg 
225                 230                 235                 240 


Arg Pro Val Ser Ala Ile Phe Thr Glu Ser Ile Gln Pro Gln Lys Pro 
                245                 250                 255     


Gly Pro Gly Ala Ala Ala Thr Val Gly Lys Val Pro Pro Thr Pro Pro 
            260                 265                 270         


Glu Lys Thr Trp Val Arg Lys Pro Arg Pro Leu Ser Met Asp Leu Thr 
        275                 280                 285             


Ala Arg Phe Glu Asn Lys Glu Ala Leu Leu Arg Lys Val Ala Asp Glu 
    290                 295                 300                 


Gly Ser Gly Pro Thr Ala Gly Asp Met Ala Gly Leu Glu Arg Pro Arg 
305                 310                 315                 320 


Ala Ala Ser Lys Leu Asp Arg Asp Cys Leu Val Lys Ala Glu Ala Pro 
                325                 330                 335     


Leu His Asp Pro Asp Leu Asp Phe Leu Glu Val Ala Lys Lys Ile Arg 
            340                 345                 350         


Glu Arg Lys Glu Lys Met Leu Ser Lys Pro Glu Met Gly Ser Pro Arg 
        355                 360                 365             


Ala Leu Val Gly Gly Ser Ser Gly Val Thr Pro Ser Asn Asp Gln Ser 
    370                 375                 380                 


Pro Trp Glu Glu Lys Ala Lys Leu Asp Pro Glu Pro Glu Lys Ala Ala 
385                 390                 395                 400 


Glu Ser Pro Ser Pro Arg Leu Gly Arg Gly Leu Glu Leu Ala Glu Val 
                405                 410                 415     


Lys Ser Arg Val Ala Asp Gly Glu Ala Ala Ala Gly Gly Glu Trp Ala 
            420                 425                 430         


Ser Arg Arg Ser Val Arg Lys Cys Ile Ser Leu Phe Arg Glu Asp Ser 
        435                 440                 445             


Thr Leu Ala Leu Ala Val Gly Ser Glu Ser Pro Leu Ala Thr Pro Ala 
    450                 455                 460                 


Ser Pro Ser Ala Ala Pro Glu Pro Glu Lys Gly Val Val Ser Val Gln 
465                 470                 475                 480 


Glu Arg Ile Arg Gly Trp Thr Ala Glu Ser Ser Glu Ala Lys Pro Glu 
                485                 490                 495     


Val Arg Arg Arg Thr Phe Gln Ala Arg Pro Leu Ser Ala Asp Leu Thr 
            500                 505                 510         


Lys Leu Phe Ser Ser Ser Ala Ser Ser Asn Glu Val Lys Tyr Glu Lys 
        515                 520                 525             


Ser Ala Glu Leu Ser Gly Glu Phe Pro Lys Glu Pro Arg Glu Lys Gln 
    530                 535                 540                 


Lys Glu Gly His Ser Leu Asp Gly Ala Cys Ile Pro Arg Ser Pro Trp 
545                 550                 555                 560 


Lys Pro Gly Thr Leu Arg Asp Lys Ser Arg Gln Thr Glu Gln Lys Val 
                565                 570                 575     


Ser Ser Asn Gln Asp Pro Asp Ser Cys Arg Gly Gly Ser Ser Val Glu 
            580                 585                 590         


Ala Pro Cys Pro Ser Asp Val Thr Pro Glu Asp Asp Arg Ser Phe Gln 
        595                 600                 605             


Thr Val Trp Ala Thr Val Phe Glu His His Val Glu Arg His Thr Val 
    610                 615                 620                 


Ala Asp Gln Ser Gly Arg Cys Leu Ser Thr Thr Pro Pro Gly Asp Met 
625                 630                 635                 640 


Ala His Ala Arg Val Ser Glu Pro Arg Pro Arg Pro Glu Met Gly Ser 
                645                 650                 655     


Trp Leu Gly Arg Asp Pro Pro Asp Met Thr Lys Leu Lys Lys Glu Asn 
            660                 665                 670         


Ser Arg Gly Phe Asp Asn Pro Glu Thr Glu Lys Leu Gly Pro Thr Thr 
        675                 680                 685             


Leu Leu Asn Gly Glu Leu Arg Pro Tyr His Thr Pro Leu Arg Asp Lys 
    690                 695                 700                 


Tyr Pro Leu Ser Glu Asn His Asn Asn Asn Thr Phe Leu Lys His Leu 
705                 710                 715                 720 


Glu Asn Pro Pro Thr Ser Gln Arg Ile Glu Pro Arg Tyr Asp Ile Val 
                725                 730                 735     


His Ala Val Gly Glu Arg Val His Ser Glu Ala Ile Ser Pro Ala Pro 
            740                 745                 750         


Glu Glu Lys Ala Val Thr Leu Arg Ser Leu Arg Ser Trp Leu Ser Leu 
        755                 760                 765             


Lys Asp Arg Gln Leu Ser Gln Glu Val Thr Pro Ala Asp Leu Glu Cys 
    770                 775                 780                 


Gly Leu Glu Gly Gln Ala Gly Ser Val Gln Arg Ala Ser Leu Ile Trp 
785                 790                 795                 800 


Glu Ala Arg Gly Met Pro Glu Ala Ser Gly Pro Lys Phe Gly Gly Asn 
                805                 810                 815     


Cys Pro Phe Pro Lys Trp Thr Gly Gly Ala Val Val Ser Ser His Lys 
            820                 825                 830         


Ala Thr Val Ala Val Ser Glu Glu His Cys Ala Pro Gly Ala Thr Ser 
        835                 840                 845             


Val Arg Ala Ile Lys Ala Ala Ile Trp Glu Ser Gln His Glu Gly Pro 
    850                 855                 860                 


Glu Gly Ala Arg Ser Lys Pro Gly Val Gly Ala Arg Gly Pro Pro Gln 
865                 870                 875                 880 


Gly Cys Pro Leu Asp Pro Leu Ser Arg Ala Thr Asn Gly Pro Ser Asp 
                885                 890                 895     


Ser Gln Ala Arg Thr His Pro Asp Ala Phe Ala Val Gln Lys Gly Pro 
            900                 905                 910         


Phe Ile Val Ala Ala Arg Glu Gly Asp Pro Gly Pro Ala Gln Val Pro 
        915                 920                 925             


Gln Pro Ala Val Arg Met Arg Lys Ala Gly Ala Met Asp Gln Arg Met 
    930                 935                 940                 


Asp Arg Trp Arg Arg Arg Thr Leu Pro Pro Asn Val Lys Phe Asp Thr 
945                 950                 955                 960 


Phe Ser Ser Leu Val Pro Glu Asp Ser Pro His Val Gly His Arg Arg 
                965                 970                 975     


Thr Asp Tyr Val Ser Pro Thr Ala Ser Ala Leu Arg Lys Pro Gln Leu 
            980                 985                 990         


Ser His Tyr Arg Val Glu Thr Gln  Glu Val Asn Pro Gly  Ala Ser Arg 
        995                 1000                 1005             


Asp Gln  Thr Ser Pro Ala Val  Lys Gln Gly Ser Pro  Val Glu Pro 
    1010                 1015                 1020             


Lys Ala  Thr Phe Phe Ala Val  Thr Tyr Gln Ile Pro  Asn Thr Gln 
    1025                 1030                 1035             


Lys Ala  Lys Gly Val Val Leu  Ser Gly Ala Glu Ser  Leu Leu Glu 
    1040                 1045                 1050             


His Ser  Arg Lys Ile Thr Pro  Pro Ser Ser Pro His  Ser Leu Thr 
    1055                 1060                 1065             


Ser Thr  Leu Val Ser Leu Gly  His Glu Glu Ala Leu  Glu Met Ala 
    1070                 1075                 1080             


Gly Ser  Lys Asn Trp Met Lys  Gly Arg Glu His Glu  Asn Ala Ser 
    1085                 1090                 1095             


Ile Leu  Lys Thr Leu Lys Pro  Thr Asp Arg Pro Ser  Ser Leu Gly 
    1100                 1105                 1110             


Ala Trp  Ser Leu Asp Pro Phe  Asn Gly Arg Ile Ile  Asp Val Asp 
    1115                 1120                 1125             


Ala Leu  Trp Ser His Arg Gly  Ser Glu Asp Gly Pro  Arg Pro Gln 
    1130                 1135                 1140             


Ser Asn  Trp Lys Glu Ser Ala  Asn Lys Met Ser Pro  Ser Gly Gly 
    1145                 1150                 1155             


Ala Pro  Gln Thr Thr Pro Thr  Leu Arg Ser Arg Pro  Lys Asp Leu 
    1160                 1165                 1170             


Pro Val  Arg Arg Lys Thr Asp  Val Ile Ser Asp Thr  Phe Pro Gly 
    1175                 1180                 1185             


Lys Ile  Arg Asp Gly Tyr Arg  Ser Ser Val Leu Asp  Ile Asp Ala 
    1190                 1195                 1200             


Leu Met  Ala Glu Tyr Gln Glu  Leu Ser Leu Lys Val  Pro Gly Glu 
    1205                 1210                 1215             


Ala Gln  Glu Arg Arg Ser Pro  Thr Val Glu Pro Ser  Thr Leu Pro 
    1220                 1225                 1230             


Arg Glu  Arg Pro Val Gln Leu  Gly Gly Val Glu Gln  Arg Arg Arg 
    1235                 1240                 1245             


Ser Leu  Lys Glu Met Pro Asp  Thr Gly Gly Leu Trp  Lys Pro Ala 
    1250                 1255                 1260             


Ser Ser  Ala Glu Ile Asn His  Ser Phe Thr Pro Gly  Leu Gly Lys 
    1265                 1270                 1275             


Gln Leu  Ala Glu Thr Leu Glu  Thr Ala Met Gly Thr  Lys Ser Ser 
    1280                 1285                 1290             


Pro Pro  Phe Trp Ala Leu Pro  Pro Ser Ala Pro Ser  Glu Arg Tyr 
    1295                 1300                 1305             


Pro Gly  Gly Ser Pro Ile Pro  Ala Asp Pro Arg Lys  Lys Thr Gly 
    1310                 1315                 1320             


Phe Ala  Glu Asp Asp Arg Lys  Ala Phe Ala Ser Lys  His His Val 
    1325                 1330                 1335             


Ala Lys  Cys Gln Asn Tyr Leu  Ala Glu Ser Lys Pro  Ser Gly Arg 
    1340                 1345                 1350             


Glu Asp  Pro Gly Ser Gly Val  Arg Val Ser Pro Lys  Ser Pro Pro 
    1355                 1360                 1365             


Thr Asp  Gln Lys Lys Gly Thr  Pro Arg Lys Ser Thr  Gly Arg Gly 
    1370                 1375                 1380             


Glu Glu  Asp Ser Val Ala Gln  Trp Gly Asp His Pro  Arg Asp Cys 
    1385                 1390                 1395             


Gly Arg  Val Pro Leu Asp Ile  Lys Arg Ala Tyr Ser  Glu Lys Gly 
    1400                 1405                 1410             


Pro Pro  Ala Asn Ile Arg Glu  Gly Leu Ser Ile Met  His Glu Ala 
    1415                 1420                 1425             


Arg Glu  Arg Arg Arg Glu Gln  Pro Lys Gly Arg Pro  Ser Leu Thr 
    1430                 1435                 1440             


Gly Glu  Asn Leu Glu Ala Lys  Met Gly Pro Cys Trp  Trp Glu Ser 
    1445                 1450                 1455             


Gly Thr  Gly Asp Ser His Lys  Val Leu Pro Arg Asp  Leu Glu Lys 
    1460                 1465                 1470             


Glu Asp  Ala Pro Gln Glu Lys  Glu Arg Pro Leu Gln  Gln Val Ser 
    1475                 1480                 1485             


Pro Val  Ala Ser Val Pro Trp  Arg Ser His Ser Phe  Cys Lys Asp 
    1490                 1495                 1500             


Arg Arg  Ser Gly Pro Phe Val  Arg Val Pro Gly Thr  Cys Gln Ala 
    1505                 1510                 1515             


Asn Ala  Leu Leu Ile Cys Ile  Ala Leu Pro Met Val  Ala Glu Leu 
    1520                 1525                 1530             


Gln Thr  Leu Pro Leu Ala Arg  Gly Leu Glu Gln Gly  Ser Pro Gln 
    1535                 1540                 1545             


Asp Leu  Glu Ser Thr Trp Arg  Ile Gln Val Leu Tyr  Gln Ala Ser 
    1550                 1555                 1560             


Ser Leu  Ser Ser Phe Pro Gln  Glu Leu Ala Gly Pro  Asn Pro Arg 
    1565                 1570                 1575             


Leu Asp  Thr His Gln Pro Val  Ser Gln Asp Thr Gln  Arg Gln Gly 
    1580                 1585                 1590             


Tyr Ser  Gln Ala Ala Gly Ile  Ile Pro Pro Ala Val  Pro Pro Val 
    1595                 1600                 1605             


Gln Arg  Asn Gln Pro Phe Cys  Cys Thr Phe Val Gly  Gln Gln Asp 
    1610                 1615                 1620             


Pro Val  Leu Trp Leu Cys Cys  Gln Leu Gly Leu Ser  Ser Asp Trp 
    1625                 1630                 1635             


Tyr Cys  Gln Leu Trp Ser Arg  Leu Ala Gly Pro Leu  Ala Val Ser 
    1640                 1645                 1650             


Arg Leu  Leu Asn Asp Leu Cys  Arg Leu Glu Leu Asp  Ser Ser Val 
    1655                 1660                 1665             


Thr Gly  Val Arg Arg Ala Ala  Pro Ala Arg Gly Lys  Leu Glu Thr 
    1670                 1675                 1680             


Val Leu  Cys Ser Pro His Asn  Leu Trp Val Leu Glu  Met Glu Tyr 
    1685                 1690                 1695             


Tyr Tyr  Cys Pro Ser Leu Leu  Lys Leu Leu Arg Tyr  Leu Trp Asp 
    1700                 1705                 1710             


Gln Leu  Lys Gln Cys Phe Ser  Arg Gln Pro Thr Glu  Pro Lys Asp 
    1715                 1720                 1725             


Thr Asp  Thr Leu Val His Glu  Ala Gly Ser Gln Tyr  Gly Thr Trp 
    1730                 1735                 1740             


Thr Glu  Gln Cys Gln Ser Gly  Glu Ser Leu Ala Thr  Glu Ser Pro 
    1745                 1750                 1755             


Asp Ser  Ser Ala Thr Ser Thr  Arg Lys Gln Pro Pro  Ser Ser Arg 
    1760                 1765                 1770             


Leu Ser  Ser Leu Ser Ser Gln  Thr Glu Pro Thr Ser  Ala Gly Asp 
    1775                 1780                 1785             


Gln Tyr  Asp Cys Ser Arg Asp  Gln Arg Ser Thr Ser  Val Asp His 
    1790                 1795                 1800             


Ser Ser  Thr Asp Leu Glu Ser  Thr Asp Gly Met Glu  Gly Pro Pro 
    1805                 1810                 1815             


Pro Pro  Asp Ala Cys Pro Glu  Lys Arg Val Asp Asp  Phe Ser Phe 
    1820                 1825                 1830             


Ile Asp  Gln Thr Ser Val Leu  Asp Ser Ser Ala Leu  Lys Thr Arg 
    1835                 1840                 1845             


Val Gln  Leu Ser Lys Arg Ser  Arg Arg Arg Ala Pro  Ile Ser His 
    1850                 1855                 1860             


Ser Leu  Arg Arg Ser Arg Phe  Ser Glu Ser Glu Ser  Arg Ser Pro 
    1865                 1870                 1875             


Leu Glu  Asp Glu Thr Asp Asn  Thr Trp Met Phe Lys  Asp Ser Thr 
    1880                 1885                 1890             


Glu Glu  Lys Ser Pro Arg Lys  Glu Glu Ser Asp Glu  Glu Glu Thr 
    1895                 1900                 1905             


Ala Ser  Lys Ala Glu Arg Thr  Pro Val Ser His Pro  Gln Arg Met 
    1910                 1915                 1920             


Pro Ala  Phe Pro Gly Met Asp  Pro Ala Val Leu Lys  Ala Gln Leu 
    1925                 1930                 1935             


His Lys  Arg Pro Glu Val Asp  Ser Pro Gly Glu Thr  Pro Ser Trp 
    1940                 1945                 1950             


Ala Pro  Gln Pro Lys Ser Pro  Lys Ser Pro Phe Gln  Pro Gly Val 
    1955                 1960                 1965             


Leu Gly  Ser Arg Val Leu Pro  Ser Ser Met Asp Lys  Asp Glu Arg 
    1970                 1975                 1980             


Ser Asp  Glu Pro Ser Pro Gln  Trp Leu Lys Glu Leu  Lys Ser Lys 
    1985                 1990                 1995             


Lys Arg  Gln Ser Leu Tyr Glu  Asn Gln Val 
    2000                 2005             


<210>  4002
<211>  853
<212>  DNA
<213>  Homosapiens

<400>  4002
gagtctgcag acggccgtgg ctcctctgtt cttcccgagg ctacagcaac agccagaggt     60

gttcctgggg agatggcgga acagcacgga gcacccgaac aggctgcagc tggcaagagc    120

catggagacc ttgggggcag ctacaaggtg atcttgtacg aactagagaa cttccaaggc    180

aaacgctgcg agctctcggc cgagtgcccc agcctgaccg acagcctgct ggagaaggtg    240

ggctccatcc aagtggagtc cgggccgtgg ctggcatttg agtccagggc cttccgcggg    300

gagcagtttg ttctggagaa gggggattat cctcgctggg atgcctggtc caacagccgt    360

gatagtgaca gccttctgtc cctccggcct ctgaatattg atagtccaca tcacaagctg    420

catctgtttg agaacccagc tttcagtggc cgcaagatgg agatagtgga tgatgacgtg    480

cccagcctgt gggctcatgg cttccaggac cgtgtggcga gtgtccgtgc catcaacggg    540

acgtgggttg gctatgagtt ccccggctac cgtgggcgcc agtacgtgtt tgagcggggc    600

gagtaccgcc actggaatga gtgggacgcc agccagccgc agctgcagtc tgtgcgccgc    660

atccgtgacc agaagtggca caagcggggc cgcttcccca gcagctgaaa ggcacccaga    720

cttcaaggac ccagacccac cctggggggc tgcaagggca agaagaggag gctccagggt    780

tggggcgagg gccgacctgt ccacccttcc ctggaatctg ctcaataaag cctggggttg    840

gtcccccacc cgc                                                       853


<210>  4003
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  4003

Met Ala Glu Gln His Gly Ala Pro Glu Gln Ala Ala Ala Gly Lys Ser 
1               5                   10                  15      


His Gly Asp Leu Gly Gly Ser Tyr Lys Val Ile Leu Tyr Glu Leu Glu 
            20                  25                  30          


Asn Phe Gln Gly Lys Arg Cys Glu Leu Ser Ala Glu Cys Pro Ser Leu 
        35                  40                  45              


Thr Asp Ser Leu Leu Glu Lys Val Gly Ser Ile Gln Val Glu Ser Gly 
    50                  55                  60                  


Pro Trp Leu Ala Phe Glu Ser Arg Ala Phe Arg Gly Glu Gln Phe Val 
65                  70                  75                  80  


Leu Glu Lys Gly Asp Tyr Pro Arg Trp Asp Ala Trp Ser Asn Ser Arg 
                85                  90                  95      


Asp Ser Asp Ser Leu Leu Ser Leu Arg Pro Leu Asn Ile Asp Ser Pro 
            100                 105                 110         


His His Lys Leu His Leu Phe Glu Asn Pro Ala Phe Ser Gly Arg Lys 
        115                 120                 125             


Met Glu Ile Val Asp Asp Asp Val Pro Ser Leu Trp Ala His Gly Phe 
    130                 135                 140                 


Gln Asp Arg Val Ala Ser Val Arg Ala Ile Asn Gly Thr Trp Val Gly 
145                 150                 155                 160 


Tyr Glu Phe Pro Gly Tyr Arg Gly Arg Gln Tyr Val Phe Glu Arg Gly 
                165                 170                 175     


Glu Tyr Arg His Trp Asn Glu Trp Asp Ala Ser Gln Pro Gln Leu Gln 
            180                 185                 190         


Ser Val Arg Arg Ile Arg Asp Gln Lys Trp His Lys Arg Gly Arg Phe 
        195                 200                 205             


Pro Ser Ser 
    210     


<210>  4004
<211>  781
<212>  DNA
<213>  Homosapiens

<400>  4004
ctcgcagggg ctggtgtcac tggtcattcc tgcacaggac agtccaccat ggcctcagat     60

caccagaccc aggcgggcaa gccacagtcc ctcaacccca agatcatcat ctttgagcag    120

gaaaactttc aaggccactc gcatgagctc aatgggccct gccccaacct gaaggaaact    180

ggcgtggaga aggcaggttc tgtcctagtg caggctggac cctgggtggg ctatgaacag    240

gccaactgca agggcgagca gtttgtgttt gagaagggtg agtacccccg ctgggactca    300

tggaccagca gccgaaggac ggactccctc agctccctga ggcccatcaa agtggacagc    360

caagagcaca agatcatcct ctatgaaaac cccaacttca ccgggaagaa gatggaaatc    420

atagatgacg atgtacccag cttccacgcc catggctacc aggagaaggt gtcatctgtg    480

cgggtgcaga gtggcacgtg ggttggctac cagtaccccg gctaccgtgg gctgcagtac    540

ctgctggaga agggagacta caaggacagc agcgactttg gggcccctca cccccaggtg    600

cagtccgtgc gccgtatccg cgacatgcag tggcaccaac gtggtgcctt ccacccctcc    660

aactagtgcc ctccccacca tgcctccttc ccaggaccca ggtctgctgc ccaggaaccc    720

tccagacctc ccagagagtg aataaagtgt gacttgcaac ttgaaaaaaa aaaaaaaaaa    780

a                                                                    781


<210>  4005
<211>  205
<212>  PRT
<213>  Homosapiens

<400>  4005

Met Ala Ser Asp His Gln Thr Gln Ala Gly Lys Pro Gln Ser Leu Asn 
1               5                   10                  15      


Pro Lys Ile Ile Ile Phe Glu Gln Glu Asn Phe Gln Gly His Ser His 
            20                  25                  30          


Glu Leu Asn Gly Pro Cys Pro Asn Leu Lys Glu Thr Gly Val Glu Lys 
        35                  40                  45              


Ala Gly Ser Val Leu Val Gln Ala Gly Pro Trp Val Gly Tyr Glu Gln 
    50                  55                  60                  


Ala Asn Cys Lys Gly Glu Gln Phe Val Phe Glu Lys Gly Glu Tyr Pro 
65                  70                  75                  80  


Arg Trp Asp Ser Trp Thr Ser Ser Arg Arg Thr Asp Ser Leu Ser Ser 
                85                  90                  95      


Leu Arg Pro Ile Lys Val Asp Ser Gln Glu His Lys Ile Ile Leu Tyr 
            100                 105                 110         


Glu Asn Pro Asn Phe Thr Gly Lys Lys Met Glu Ile Ile Asp Asp Asp 
        115                 120                 125             


Val Pro Ser Phe His Ala His Gly Tyr Gln Glu Lys Val Ser Ser Val 
    130                 135                 140                 


Arg Val Gln Ser Gly Thr Trp Val Gly Tyr Gln Tyr Pro Gly Tyr Arg 
145                 150                 155                 160 


Gly Leu Gln Tyr Leu Leu Glu Lys Gly Asp Tyr Lys Asp Ser Ser Asp 
                165                 170                 175     


Phe Gly Ala Pro His Pro Gln Val Gln Ser Val Arg Arg Ile Arg Asp 
            180                 185                 190         


Met Gln Trp His Gln Arg Gly Ala Phe His Pro Ser Asn 
        195                 200                 205 


<210>  4006
<211>  914
<212>  DNA
<213>  Homosapiens

<400>  4006
tgtggcagat ttcagaggcc cttaaaatga ggccaagtga ggtggacagg tccgagccag     60

ctgaggactc ctcagccaca cggcacagct gcctgagggg atgtgtcact cagggagttg    120

ctgggaccta ctgggcccag cgttgccatc agcaccaaca gcttcagaga gggggacaca    180

tgccggggtg actccaaggc tgtgggcggc acctgcctca gatagagaac aggcacagag    240

acactactgg gggacactac tgggacactg gccacccccc taccctgtgc ctagatcaca    300

gcctacacac tgcagccctg tgcccctcac acccagcagg ttcctgctcc agcgcggctc    360

ctggactggc cccgggtgct ggccccgggg gtttcaatcc aagcataatt cagtgaagca    420

tgtgtttggc agcgggaccc agctcaccgt tttaggtcag cccaaggcca ccccctcggt    480

cactctgttc ctgccgtcct ctgaggagct ccaagccaac aaggccacac tggtgtgtct    540

catgaatgac ttctatctgg gaatcttgac ggtgacctgg aaggcagatg gtacccccat    600

cacccagggc gtggagatga ccacgccctc caaacagagc aacagcaagt acatggccag    660

cagctacctg agcctgacgc ccgagcagtg gaggtcccgc agaagctaca gctgccaggt    720

catgcatgaa gggagcactg cagagaagac ggtggcccct gcagaatgtt cataggttcc    780

cagcccccac cccacccaca ggggcctgga gctgcaggat cccaggggag gcgtctctct    840

ctgcatccca agccatccag cccttctccc tgtacccagt aaaccctcag taaatatcct    900

ctttgtcaac caga                                                      914


<210>  4007
<211>  224
<212>  PRT
<213>  Homosapiens

<400>  4007

Met Cys His Ser Gly Ser Cys Trp Asp Leu Leu Gly Pro Ala Leu Pro 
1               5                   10                  15      


Ser Ala Pro Thr Ala Ser Glu Arg Gly Thr His Ala Gly Val Thr Pro 
            20                  25                  30          


Arg Leu Trp Ala Ala Pro Ala Ser Asp Arg Glu Gln Ala Gln Arg His 
        35                  40                  45              


Tyr Trp Gly Thr Leu Leu Gly His Trp Pro Pro Pro Tyr Pro Val Pro 
    50                  55                  60                  


Arg Ser Gln Pro Thr His Cys Ser Pro Val Pro Leu Thr Pro Ser Arg 
65                  70                  75                  80  


Phe Leu Leu Gln Arg Gly Ser Trp Thr Gly Pro Gly Cys Trp Pro Arg 
                85                  90                  95      


Gly Phe Gln Ser Lys His Asn Ser Val Lys His Val Phe Gly Ser Gly 
            100                 105                 110         


Thr Gln Leu Thr Val Leu Gly Gln Pro Lys Ala Thr Pro Ser Val Thr 
        115                 120                 125             


Leu Phe Leu Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Met Asn Asp Phe Tyr Leu Gly Ile Leu Thr Val Thr Trp 
145                 150                 155                 160 


Lys Ala Asp Gly Thr Pro Ile Thr Gln Gly Val Glu Met Thr Thr Pro 
                165                 170                 175     


Ser Lys Gln Ser Asn Ser Lys Tyr Met Ala Ser Ser Tyr Leu Ser Leu 
            180                 185                 190         


Thr Pro Glu Gln Trp Arg Ser Arg Arg Ser Tyr Ser Cys Gln Val Met 
        195                 200                 205             


His Glu Gly Ser Thr Ala Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
    210                 215                 220                 


<210>  4008
<211>  3601
<212>  DNA
<213>  Homosapiens

<400>  4008
gcctagaggg agaaaacttg ttgaaattca gagatccccc tccccctacc agtacacacc     60

aaatcagacg cctctgacca gatctgaatt tggctctcag agatttccat tgtagccagg    120

cagttggggc actttctgag tgctgcctcc acctcactgt ccccagcctg cctgcctccg    180

tttccctagc cctgggcctg tgccgctgtc accatcacct gggcgccctc tagtggatga    240

atcggattat gcacgagggg gcttggagca ggattcagaa ggggctcctg tccttccttg    300

aaatgctgga cgccgggatc ctggaacagc tcttcaggtc tctgcattcc tcctggcaac    360

agccagagcc tgggcgcagg gggctactgt tgtttgaagg ctgaaggctg cagcctggta    420

gggcactcag gagacctggc agttggctgc agggccaggt ctaggggcca gggcatgagg    480

gatgctctgg gctggctcag ccccgggccc ccatgcggat tgtgactgtg ggggcatggc    540

cacatgatgt tgagggggga tctctgaccc tgaccttctt ggctctgtgc atccttgaaa    600

ccagaaaggt ctggaacaaa tcagtgaaca atgccctaac tcggggaggg agccacatcc    660

tgaccccagc agcctcagaa ggatccgtgt cagggttatg gggcaccctg ggggccccga    720

gtctgcatgg gtctccacgt gcaacttctg ccggaaactc tgaaaaatcc caactgcggg    780

ggtcatagga cacaatcaga aatgctgatg ccactgtgtg tggatccccg ggccctgggg    840

gtcaggagca tgtagaaggt gggccacagg gggttcataa gagaatcctg taaccgcccc    900

tgccccccaa acttagaagc ccactggagg gccatgggtg aaagcttggg ggggtgtcct    960

gtggagtggg tggtgggggg tctttgggtt tacatgctgc tgggcctgag cagcaggacc   1020

ccgtccacag ctgatccctg ggccctgctg ctcagctgct ctcttgagtg ttgctgtggc   1080

tgccgagaga gcctgagtcg agcctctctt gtgccggccg tacgctgtca ggccacgctg   1140

gtgagtttgg caaggcacag atgcccagag cagagaactt tccttgggga tttaatatgt   1200

gcgaatcttg aggtccggca aatctttccc tcagctagag agggggtttt tgagaccaga   1260

atcacctcag catcctcctg tccccagctg tgtccagcct gtctgcaggg acatcctgag   1320

aggactaggc tctcccctca tccacctgcg taagtgccac cctgaagcct gtccacccat   1380

gcttggagag gcttggcctc aacctgctta gccagcagca ggcttgggcc tggggtgcag   1440

tagagaccca ggtggctgtg gggtggttgc ttcatggggt ggttctgaaa cgcagttgga   1500

agtgcatgga cagtgcctta cctgttctct gtgggaccct gtttagaaac caggtctgag   1560

ttactggggg tcatcgctac attctgatgg cctagctgtg tggaggccac ggtggagccc   1620

catccaagga gccagggccc tgggtctagc cgtgaccaga acgcatgccc tggaggtgtt   1680

tctcatcttg cacctgtgtt gcctggtgtc tcaagtggcc acaaaactct gtgttagctc   1740

taggtgcccc tgggcttcgg aaccagggtt tcccttcatc tcagtgaccc gggagcatct   1800

gggcagtgag taaagagggt gatttacttg atgggtacgt ttggtcctgc ctaggagccc   1860

ccccaggcac ggtcctggga cctgaagctg ccctcgttgg tggaggggag ggagagagct   1920

tcagggatga ggtggcgttg agctgggcgg gaagggtgag cccctgcaag gtggggtggg   1980

tgtgctgggg acgctgagca gcacggccag caggtgggtc ttcagctcgg tacccggtgg   2040

gacttgtggt tggggctggt gtgtggccag gagaggggct ggcagaagac aagggggact   2100

gtgaggcagc tcccatccag cggttgaagc ctgatggcct ggctctgtgc ctcagttctc   2160

tcatctataa aatgagaaaa cagtgccagc ctcccagacc tgtcatgagg atgaacgagt   2220

gaccacgtag catgggctgg gtgcgtgtca cctaacatta ccagcctttg caaggagagc   2280

cctggggacc tggctgagtt tttcccttgc ctggcccact gcacctgtcc ccacaggagc   2340

caaggaggtc ctgctgctgg cccggtagac ggaccaatgg agggtctcgc tggacacacc   2400

ggacttcacc gacatcgtgc tgcagctgga cgacatccag catgccatcg ccatcaacta   2460

tgacccaatg gagggccacg tctactggac ggatgacgag gtgtgggcca tccgcagggc   2520

atacctggat gggtctgggg cgcagacgct gatcaacacc aagatcaacg accccgatga   2580

catcgcagtc aactgggtgg cccgaagcct ctattggacc cacacaggca ctgaacacat   2640

cgaggtgacg tgcctcaaca gcacctccca caagatcctg gtgtcagagg acatggacga   2700

gccccgtgcc attgcactgc atcccgagat gggcctcacg tactggatag actggggaga   2760

gaaccctgaa atcaagcgtg ccaacctgga caggcaggag ctgcgcgtgc tggtcaatgc   2820

ttccctcggg tggcccaacg gcctggccct ggacctgcag gaagggaagc tctactgggg   2880

agatgccaag acagataaga tcgaggcgat cagtgtcgat gagacgaaga ggcagaccct   2940

cctgaaggac aagctcccac acattttcag gttcaccctg ctgggggact tcatctactg   3000

gaccgcctgg cagcaccaca gcatcaagcg ggtacacaag gtcaaggcca accgggacgt   3060

catcattgac cagctgcccg acctgatggg gctcaaagct gtgaacgtgg acaaggtcgt   3120

cggaaccaac cctcatgcgg acaggaatgg gggtgcagcc acctgtgctt cttcacgccc   3180

cacacaaccc ggtttggctg ccccatctag ggcctggaac tgctgagtga catgaagacc   3240

tgcatcatgc ccaaggcctt cttggtcttc accagtagag ccgccatcca caggatctcc   3300

ctcgagacca acaacaacga tgtggccatc ctgctctcgg cgtcaaggag gcctcggccc   3360

tggactttga tgtgtccagc aaccacatct actggacaga catcagcctg aaggtagcgt   3420

gggcccgaac atgcacacgt gcagcctata tgggaaaacc ttccctctgt acctgcctca   3480

aaggtttcag acatttttct taaagcacta taatatttat tgtaacacaa ttcaagctaa   3540

ttaaatatga gcaagcctat ttcaaaaaaa aaaaaaaaaa aaaacaaaaa aaaaaaaaaa   3600

a                                                                   3601


<210>  4009
<211>  252
<212>  PRT
<213>  Homosapiens

<400>  4009

Met Glu Gly His Val Tyr Trp Thr Asp Asp Glu Val Trp Ala Ile Arg 
1               5                   10                  15      


Arg Ala Tyr Leu Asp Gly Ser Gly Ala Gln Thr Leu Ile Asn Thr Lys 
            20                  25                  30          


Ile Asn Asp Pro Asp Asp Ile Ala Val Asn Trp Val Ala Arg Ser Leu 
        35                  40                  45              


Tyr Trp Thr His Thr Gly Thr Glu His Ile Glu Val Thr Cys Leu Asn 
    50                  55                  60                  


Ser Thr Ser His Lys Ile Leu Val Ser Glu Asp Met Asp Glu Pro Arg 
65                  70                  75                  80  


Ala Ile Ala Leu His Pro Glu Met Gly Leu Thr Tyr Trp Ile Asp Trp 
                85                  90                  95      


Gly Glu Asn Pro Glu Ile Lys Arg Ala Asn Leu Asp Arg Gln Glu Leu 
            100                 105                 110         


Arg Val Leu Val Asn Ala Ser Leu Gly Trp Pro Asn Gly Leu Ala Leu 
        115                 120                 125             


Asp Leu Gln Glu Gly Lys Leu Tyr Trp Gly Asp Ala Lys Thr Asp Lys 
    130                 135                 140                 


Ile Glu Ala Ile Ser Val Asp Glu Thr Lys Arg Gln Thr Leu Leu Lys 
145                 150                 155                 160 


Asp Lys Leu Pro His Ile Phe Arg Phe Thr Leu Leu Gly Asp Phe Ile 
                165                 170                 175     


Tyr Trp Thr Ala Trp Gln His His Ser Ile Lys Arg Val His Lys Val 
            180                 185                 190         


Lys Ala Asn Arg Asp Val Ile Ile Asp Gln Leu Pro Asp Leu Met Gly 
        195                 200                 205             


Leu Lys Ala Val Asn Val Asp Lys Val Val Gly Thr Asn Pro His Ala 
    210                 215                 220                 


Asp Arg Asn Gly Gly Ala Ala Thr Cys Ala Ser Ser Arg Pro Thr Gln 
225                 230                 235                 240 


Pro Gly Leu Ala Ala Pro Ser Arg Ala Trp Asn Cys 
                245                 250         


<210>  4010
<211>  3628
<212>  DNA
<213>  Homosapiens

<400>  4010
gcgggcgcgc gtcccgtcca ggtccggagt aaccgccgcc gccgccgcca aagctcgcca     60

acatggcgga cctggaggcc gtgctggccg atgtcagtta cctgatggcc atggagaaga    120

gcaaggcgac cccggccgcc cgcgccagca agaggatcgt cctgccggag cccagtatcc    180

ggagtgtgat gcagaagtac cttgcagaga gaaatgaaat aacctttgac aagattttca    240

atcagaaaat tggtttcttg ctatttaaag atttttgttt gaatgaaatt aatgaagctg    300

tacctcaggt gaagttttat gaagagataa aggaatatga aaaacttgat aatgaggaag    360

accgcctttg cagaagtcga caaatttatg atgcctacat catgaaggaa cttctttcct    420

gttcacatcc tttctcaaag caagctgtag aacacgtaca aagtcattta tccaagaaac    480

aagtgacatc aactcttttt cagccataca tagaagaaat ttgtgaaagc cttcgaggtg    540

acatttttca aaaatttatg gaaagtgaca agttcactag attttgtcag tggaaaaacg    600

ttgaattaaa tatccatttg accatgaatg agttcagtgt gcataggatt attggacgag    660

gaggattcgg ggaagtttat ggttgcagga aagcagacac tggaaaaatg tatgcaatga    720

aatgcttaga taagaagagg atcaaaatga aacaaggaga aacattagct ttaaatgaaa    780

gaatcatgtt gtctcttgtc agcacaggag actgtccttt cattgtatgt atgacctatg    840

ccttccatac cccagataaa ctctgcttca tcctggatct gatgaacggg ggcgatttgc    900

actaccacct ttcacaacac ggtgtgttct ctgagaagga gatgcggttt tatgccactg    960

aaatcattct gggtctggaa cacgtgcaca atcggtttgt tgtctacaga gatttgaagc   1020

cagcaaatat tctcttggat gaacatggac acgcaagaat atcagatctt ggtcttgcct   1080

gcgatttttc caaaaagaag cctcatgcga gtgttggcac ccatgggtac atggctcccg   1140

aggtgctgca gaaggggacg gcctatgaca gcagtgccga ctggttctcc ctgggctgca   1200

tgcttttcaa acttctgaga ggtcacagcc ctttcagaca acataaaacc aaagacaagc   1260

atgaaattga ccgaatgaca ctcaccgtga atgtggaact tccagacacc ttctctcctg   1320

aactgaagtc ccttttggag ggcttgcttc agcgagacgt tagcaagcgg ctgggctgtc   1380

acggaggcgg ctcacaggaa gtaaaagagc acagcttttt caaaggtgtt gactggcagc   1440

atgtctactt acaaaagtac ccaccaccct tgattcctcc ccggggagaa gtcaatgctg   1500

ctgatgcctt tgatattggc tcatttgatg aagaggatac caaagggatt aagctacttg   1560

attgcgacca agaactctac aagaacttcc ctttggtcat ctctgaacgc tggcagcaag   1620

aagtaacgga aacagtttat gaagcagtaa atgcagacac agataaaatc gaggccagga   1680

agagagctaa aaataagcaa cttggccacg aagaagatta cgctctgggg aaggactgta   1740

ttatgcacgg gtacatgctg aaactgggaa acccatttct gactcagtgg cagcgtcgct   1800

atttttacct ctttccaaat agacttgaat ggagaggaga gggagagtcc cggcaaaatt   1860

tactgacaat ggaacagatt ctctctgtgg aagaaactca aattaaagac aaaaaatgca   1920

ttttgttcag aataaaagga gggaaacaat ttgtcttgca atgtgagagt gatccagagt   1980

ttgtgcagtg gaagaaagag ttgaacgaaa ccttcaagga ggcccagcgg ctattgcgtc   2040

gtgccccgaa gttcctcaac aaacctcggt caggtactgt ggagctccca aagccatccc   2100

tctgtcacag gaacagcaac ggcctctgac acccagaaac agggagggtc ctcgaggagg   2160

acacaccagg gtctcagcct tttggggtga acgaggatga ggcatctgat ctattcgcta   2220

ccgggactcc tccaggctcc cgagaggagt cgggaccctt cggcttgggg tcagctcagc   2280

tccctgcctt gtcacatttg tctgcattag aaactactga agaaataaaa gttctttttc   2340

tttgctacac actttggtac ctatgaacct agaacttgaa gtgactccta cttatcacgt   2400

aaatttttat gtctgatatc aaacacatct tagactcccc agaatggaat ttaaagatgt   2460

tcagtgttgg gtaacagatt gccctaagca ttgccacata ttctgtctag tcactgctga   2520

ttttctatgt ctttgctcca tactgctggg ggatgggaga gccacagtgt gtttcttttg   2580

tgcacttcgc aactgacttc ttgtcctggg gttaaaagtt gaagatattt tctgatgata   2640

ttaaaagttg aagatatttc tgcacttggg ccctcctctg ggagccgcac ccacatgact   2700

gccctgcctc tgaccagtct gttccggggc cccctcagcc aggtgggaat gacggacacg   2760

tactatccaa gtgtatggga ttaactaatc attgaaggca ttcatccgtc catcattgga   2820

aagatttaca gtgattctga aggacaggcc gtggagtttt aggtttcagg ggcaagagca   2880

gttttcaaaa gtctttgagt ccagtgtgca cgagtcgaca agcagtacct ggcatgcagg   2940

agcactcatg ggtgagtccg tctcaggtct cgacaattag cagttgtgtg acagtcattc   3000

tggttccttc tgcctgaccc tgggagacat atcagtaatg gatgtacaaa agcaggtctg   3060

ttttatgtct tagtataatt tcagatgaat tgtattgaaa aaatgctgag gaatgaatgt   3120

gtcaaaatgg gttaactgtg tatattgact ttcatgtcgt catgcatctg tcatgaatga   3180

atgatacttt gcactgggct gtacgacagt gaggacctta gggcatgaag cctttttcct   3240

ggtcccagca gcatctgccc tgtgaagttt gttttctccc actgcctcca ggccccactg   3300

atacccccaa atagatgctg ggttatgaga accagcgaaa tcccccatgt catcagtctt   3360

aaaaaaaaaa ttttacaaat ccacgtattt gtcccattct tggagtagtt ttagtgtatg   3420

tctttacatt aactactaac agtataaata acttgacatc gtaattgtct gcatcctgtc   3480

cttgatattt ttagcagttc caaatctttg tttttgtatt tgtttgctgt gttcatgggc   3540

aaagtaagta ctttttaatg cagttatttt gagagtttgg aagataatta ccaaaagggt   3600

ccattatttc ataagagtta ctttgcaa                                      3628


<210>  4011
<211>  688
<212>  PRT
<213>  Homosapiens

<400>  4011

Met Ala Asp Leu Glu Ala Val Leu Ala Asp Val Ser Tyr Leu Met Ala 
1               5                   10                  15      


Met Glu Lys Ser Lys Ala Thr Pro Ala Ala Arg Ala Ser Lys Arg Ile 
            20                  25                  30          


Val Leu Pro Glu Pro Ser Ile Arg Ser Val Met Gln Lys Tyr Leu Ala 
        35                  40                  45              


Glu Arg Asn Glu Ile Thr Phe Asp Lys Ile Phe Asn Gln Lys Ile Gly 
    50                  55                  60                  


Phe Leu Leu Phe Lys Asp Phe Cys Leu Asn Glu Ile Asn Glu Ala Val 
65                  70                  75                  80  


Pro Gln Val Lys Phe Tyr Glu Glu Ile Lys Glu Tyr Glu Lys Leu Asp 
                85                  90                  95      


Asn Glu Glu Asp Arg Leu Cys Arg Ser Arg Gln Ile Tyr Asp Ala Tyr 
            100                 105                 110         


Ile Met Lys Glu Leu Leu Ser Cys Ser His Pro Phe Ser Lys Gln Ala 
        115                 120                 125             


Val Glu His Val Gln Ser His Leu Ser Lys Lys Gln Val Thr Ser Thr 
    130                 135                 140                 


Leu Phe Gln Pro Tyr Ile Glu Glu Ile Cys Glu Ser Leu Arg Gly Asp 
145                 150                 155                 160 


Ile Phe Gln Lys Phe Met Glu Ser Asp Lys Phe Thr Arg Phe Cys Gln 
                165                 170                 175     


Trp Lys Asn Val Glu Leu Asn Ile His Leu Thr Met Asn Glu Phe Ser 
            180                 185                 190         


Val His Arg Ile Ile Gly Arg Gly Gly Phe Gly Glu Val Tyr Gly Cys 
        195                 200                 205             


Arg Lys Ala Asp Thr Gly Lys Met Tyr Ala Met Lys Cys Leu Asp Lys 
    210                 215                 220                 


Lys Arg Ile Lys Met Lys Gln Gly Glu Thr Leu Ala Leu Asn Glu Arg 
225                 230                 235                 240 


Ile Met Leu Ser Leu Val Ser Thr Gly Asp Cys Pro Phe Ile Val Cys 
                245                 250                 255     


Met Thr Tyr Ala Phe His Thr Pro Asp Lys Leu Cys Phe Ile Leu Asp 
            260                 265                 270         


Leu Met Asn Gly Gly Asp Leu His Tyr His Leu Ser Gln His Gly Val 
        275                 280                 285             


Phe Ser Glu Lys Glu Met Arg Phe Tyr Ala Thr Glu Ile Ile Leu Gly 
    290                 295                 300                 


Leu Glu His Val His Asn Arg Phe Val Val Tyr Arg Asp Leu Lys Pro 
305                 310                 315                 320 


Ala Asn Ile Leu Leu Asp Glu His Gly His Ala Arg Ile Ser Asp Leu 
                325                 330                 335     


Gly Leu Ala Cys Asp Phe Ser Lys Lys Lys Pro His Ala Ser Val Gly 
            340                 345                 350         


Thr His Gly Tyr Met Ala Pro Glu Val Leu Gln Lys Gly Thr Ala Tyr 
        355                 360                 365             


Asp Ser Ser Ala Asp Trp Phe Ser Leu Gly Cys Met Leu Phe Lys Leu 
    370                 375                 380                 


Leu Arg Gly His Ser Pro Phe Arg Gln His Lys Thr Lys Asp Lys His 
385                 390                 395                 400 


Glu Ile Asp Arg Met Thr Leu Thr Val Asn Val Glu Leu Pro Asp Thr 
                405                 410                 415     


Phe Ser Pro Glu Leu Lys Ser Leu Leu Glu Gly Leu Leu Gln Arg Asp 
            420                 425                 430         


Val Ser Lys Arg Leu Gly Cys His Gly Gly Gly Ser Gln Glu Val Lys 
        435                 440                 445             


Glu His Ser Phe Phe Lys Gly Val Asp Trp Gln His Val Tyr Leu Gln 
    450                 455                 460                 


Lys Tyr Pro Pro Pro Leu Ile Pro Pro Arg Gly Glu Val Asn Ala Ala 
465                 470                 475                 480 


Asp Ala Phe Asp Ile Gly Ser Phe Asp Glu Glu Asp Thr Lys Gly Ile 
                485                 490                 495     


Lys Leu Leu Asp Cys Asp Gln Glu Leu Tyr Lys Asn Phe Pro Leu Val 
            500                 505                 510         


Ile Ser Glu Arg Trp Gln Gln Glu Val Thr Glu Thr Val Tyr Glu Ala 
        515                 520                 525             


Val Asn Ala Asp Thr Asp Lys Ile Glu Ala Arg Lys Arg Ala Lys Asn 
    530                 535                 540                 


Lys Gln Leu Gly His Glu Glu Asp Tyr Ala Leu Gly Lys Asp Cys Ile 
545                 550                 555                 560 


Met His Gly Tyr Met Leu Lys Leu Gly Asn Pro Phe Leu Thr Gln Trp 
                565                 570                 575     


Gln Arg Arg Tyr Phe Tyr Leu Phe Pro Asn Arg Leu Glu Trp Arg Gly 
            580                 585                 590         


Glu Gly Glu Ser Arg Gln Asn Leu Leu Thr Met Glu Gln Ile Leu Ser 
        595                 600                 605             


Val Glu Glu Thr Gln Ile Lys Asp Lys Lys Cys Ile Leu Phe Arg Ile 
    610                 615                 620                 


Lys Gly Gly Lys Gln Phe Val Leu Gln Cys Glu Ser Asp Pro Glu Phe 
625                 630                 635                 640 


Val Gln Trp Lys Lys Glu Leu Asn Glu Thr Phe Lys Glu Ala Gln Arg 
                645                 650                 655     


Leu Leu Arg Arg Ala Pro Lys Phe Leu Asn Lys Pro Arg Ser Gly Thr 
            660                 665                 670         


Val Glu Leu Pro Lys Pro Ser Leu Cys His Arg Asn Ser Asn Gly Leu 
        675                 680                 685             


<210>  4012
<211>  1070
<212>  DNA
<213>  Homosapiens

<400>  4012
gcacttctgg gcttcagcac acatcagtgt ggttcacgtg tttcctgctg ttatgaaaga     60

gattggagag gactaagctt ggaattgcct gtcccacagc aagaggctat ggagctgggc    120

cacggagcag ggcccatctg aatgacaagg agggccaaca ggacttggac ccctggaaag    180

cggcctacag ttccttggac acctccaagt tcaagaacca gggtctgtca tccccacagc    240

ccctgcccct gggatccagc actcaaggca gctccctagg gcagtgccac ttgaaggaga    300

ttccccctcc acccccgact gctgccagca gggattctct gggcatggac ccacagtcca    360

ggtccctgaa gaatgcgggc tctcgatcct cctcgagaga gaacagggcc acctcgggag    420

agggggctca gccatgccag gggacggatg acggtcccag cttgggggct caggaccaga    480

ggagcacgcc cacgaaccag aagggcagca tcattcctaa caacattcgc cacaagtttg    540

ggagcaatgt ggtggaccag ctggtctccg aggagcaggc tcaaaaggct attgatgaag    600

tcttcgaggg ccagaaaagg gcaagctcat ggcccagcag gacccagaat cctgtggaaa    660

tctcctccgt cttctcagac tactatgacc tcggctacaa catgcggtca aacttgtttc    720

gaggggctgc tgaggagaca aagagcctca tgaaggcttc ttacacacca gaggtcattg    780

agaaatcagt gagggactta gaacactggc atggcaggaa gacggatgat ctggggcggt    840

ggcaccagaa aaatgctatg aacctgaact tgcagaaagc actggaagag aaatatggag    900

aaaacagcaa atccaagagc tccaagtact agttttgaca cagtagaggt gtcttctact    960

caaataaagt gctaacaata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa              1070


<210>  4013
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  4013

Met Asp Pro Gln Ser Arg Ser Leu Lys Asn Ala Gly Ser Arg Ser Ser 
1               5                   10                  15      


Ser Arg Glu Asn Arg Ala Thr Ser Gly Glu Gly Ala Gln Pro Cys Gln 
            20                  25                  30          


Gly Thr Asp Asp Gly Pro Ser Leu Gly Ala Gln Asp Gln Arg Ser Thr 
        35                  40                  45              


Pro Thr Asn Gln Lys Gly Ser Ile Ile Pro Asn Asn Ile Arg His Lys 
    50                  55                  60                  


Phe Gly Ser Asn Val Val Asp Gln Leu Val Ser Glu Glu Gln Ala Gln 
65                  70                  75                  80  


Lys Ala Ile Asp Glu Val Phe Glu Gly Gln Lys Arg Ala Ser Ser Trp 
                85                  90                  95      


Pro Ser Arg Thr Gln Asn Pro Val Glu Ile Ser Ser Val Phe Ser Asp 
            100                 105                 110         


Tyr Tyr Asp Leu Gly Tyr Asn Met Arg Ser Asn Leu Phe Arg Gly Ala 
        115                 120                 125             


Ala Glu Glu Thr Lys Ser Leu Met Lys Ala Ser Tyr Thr Pro Glu Val 
    130                 135                 140                 


Ile Glu Lys Ser Val Arg Asp Leu Glu His Trp His Gly Arg Lys Thr 
145                 150                 155                 160 


Asp Asp Leu Gly Arg Trp His Gln Lys Asn Ala Met Asn Leu Asn Leu 
                165                 170                 175     


Gln Lys Ala Leu Glu Glu Lys Tyr Gly Glu Asn Ser Lys Ser Lys Ser 
            180                 185                 190         


Ser Lys Tyr 
        195 


<210>  4014
<211>  1167
<212>  DNA
<213>  Homosapiens

<400>  4014
gccaacttct ccagccggcc ggggcgagcg ccagcgcggc gtccggggcg agtgacacgc     60

agagctgaag ccatggttca tcaggtgctc taccgggcgc tggtctccac caagtggctg    120

gcggagtcca tcaggactgg caagctgggg cccggcctgc gggtgctgga cgcgtcctgg    180

tactcaccag gcacccgaga ggcccgcaag gagtacctcg agcgccacgt acccggcgcc    240

tctttctttg acatagaaga gtgccgggac acggcgtcgc cctacgagat gatgctgccc    300

agcgaggctg gcttcgccga gtatgtgggc cgcctgggca tcagcaacca cacgcacgtg    360

gtggtgtatg atggtgaaca cctgggcagc ttctatgctc cccgggtctg gtggatgttc    420

cgtgtgtttg gccaccgcac cgtatcagtg ctcaatggtg gcttccggaa ctggctgaag    480

gagggccacc cggtgacatc cgagccctca cgcccagaac cggccgtctt caaagccaca    540

ctggaccgct ccctgctcaa gacctacgag caggtgctgg agaaccttga atctaagagg    600

ttccagctgg tggattcaag gtctcaaggg cggttcctgg gcaccgagcc ggagccggat    660

gcagtaggac tggactcggg ccatatccgt ggtgccgtca acatgccttt catggacttc    720

ctgactgagg atggcttcga gaagggccca gaagagctcc gtgctctgtt ccagaccaag    780

aaggtggatc tctcgcagcc tctcattgcc acgtgccgca agggagtcac cgcctgccac    840

gtggccttgg ctgcctacct ctgcggcaag cctgatgtgg ccgtgtacga tggctcctgg    900

tccgagtggt ttcgccgggc ccccccagag agccgtgtgt cccagggaaa gtctgagaag    960

gcctgagccg tgacctcttc tgcttactgt aactgcggcc ggtttagtga ccccatgact   1020

tacagccggt tcttacctct taggtgaagg agatgacatg tttttagaat tgctgtgcaa   1080

ggctcaccct ctctctgtca acactggaat aaactttgcc ttttctgaaa aaaaaaaaaa   1140

aaaaaaaaaa aaaaaaaaaa aaaaaaa                                       1167


<210>  4015
<211>  297
<212>  PRT
<213>  Homosapiens

<400>  4015

Met Val His Gln Val Leu Tyr Arg Ala Leu Val Ser Thr Lys Trp Leu 
1               5                   10                  15      


Ala Glu Ser Ile Arg Thr Gly Lys Leu Gly Pro Gly Leu Arg Val Leu 
            20                  25                  30          


Asp Ala Ser Trp Tyr Ser Pro Gly Thr Arg Glu Ala Arg Lys Glu Tyr 
        35                  40                  45              


Leu Glu Arg His Val Pro Gly Ala Ser Phe Phe Asp Ile Glu Glu Cys 
    50                  55                  60                  


Arg Asp Thr Ala Ser Pro Tyr Glu Met Met Leu Pro Ser Glu Ala Gly 
65                  70                  75                  80  


Phe Ala Glu Tyr Val Gly Arg Leu Gly Ile Ser Asn His Thr His Val 
                85                  90                  95      


Val Val Tyr Asp Gly Glu His Leu Gly Ser Phe Tyr Ala Pro Arg Val 
            100                 105                 110         


Trp Trp Met Phe Arg Val Phe Gly His Arg Thr Val Ser Val Leu Asn 
        115                 120                 125             


Gly Gly Phe Arg Asn Trp Leu Lys Glu Gly His Pro Val Thr Ser Glu 
    130                 135                 140                 


Pro Ser Arg Pro Glu Pro Ala Val Phe Lys Ala Thr Leu Asp Arg Ser 
145                 150                 155                 160 


Leu Leu Lys Thr Tyr Glu Gln Val Leu Glu Asn Leu Glu Ser Lys Arg 
                165                 170                 175     


Phe Gln Leu Val Asp Ser Arg Ser Gln Gly Arg Phe Leu Gly Thr Glu 
            180                 185                 190         


Pro Glu Pro Asp Ala Val Gly Leu Asp Ser Gly His Ile Arg Gly Ala 
        195                 200                 205             


Val Asn Met Pro Phe Met Asp Phe Leu Thr Glu Asp Gly Phe Glu Lys 
    210                 215                 220                 


Gly Pro Glu Glu Leu Arg Ala Leu Phe Gln Thr Lys Lys Val Asp Leu 
225                 230                 235                 240 


Ser Gln Pro Leu Ile Ala Thr Cys Arg Lys Gly Val Thr Ala Cys His 
                245                 250                 255     


Val Ala Leu Ala Ala Tyr Leu Cys Gly Lys Pro Asp Val Ala Val Tyr 
            260                 265                 270         


Asp Gly Ser Trp Ser Glu Trp Phe Arg Arg Ala Pro Pro Glu Ser Arg 
        275                 280                 285             


Val Ser Gln Gly Lys Ser Glu Lys Ala 
    290                 295         


<210>  4016
<211>  1352
<212>  DNA
<213>  Homosapiens

<400>  4016
gggcggagcg ggcgtacccc cacggcccgg ccagtggaag gcgcgggcag cagcggctcc     60

gagtggccgc ggcggtgggc tgtgccggag tctcctccct ttggtccgct gcaggcccgc    120

agcccgagtg tcgccgccat ggcttcgccg cagctctgcc gcgcgctggt gtcggcgcaa    180

tgggtggcgg aggcgctgcg ggccccgcgc gctgggcagc ctctgcagct gctggacgcc    240

tcctggtacc tgccgaagct ggggcgcgac gcgcgacgcg agttcgagga gcgccacatc    300

ccgggcgccg ctttcttcga catcgaccag tgcagcgacc gcacctcgcc ctacgaccac    360

atgctgcccg gggccgagca tttcgcggag tacgcaggcc gcctgggcgt gggcgcggcc    420

acccacgtcg tgatctacga cgccagcgac cagggcctct actccgcccc gcgcgtctgg    480

tggatgttcc gcgccttcgg ccaccacgcc gtgtcactgc ttgatggcgg cctccgccac    540

tggctgcgcc agaacctccc gctcagctcc ggcaagagcc aacctgctcc cgccgagttc    600

cgcgctcagc tcgaccccgc cttcatcaag acctacgagg acatcaagga gaacctggaa    660

tcccggcgct tccaggtggt ggactcccga gccactggca ggttccgcgg caccgagccc    720

gagccccgag acggcattga acctggccac atcccaggta ccgtgaacat ccccttcaca    780

gacttcctga gccaggaggg gctggagaag agccctgagg agatccgcca tctgttccag    840

gagaagaaag tggacctgtc taagccactg gtggccacgt gtggctctgg cgtcacagcc    900

tgccacgtgg cactaggggc ctacctctgc ggcaagccag acgtgcccat ctacgatggc    960

tcctgggtgg agtggtacat gcgcgcccgg cccgaggatg tcatctcaga gggccggggg   1020

aagacccact gaagctgggc aggacacagg cgagctcagg tgatgccggc caccagcaat   1080

gcctggcctg gtagctccgc ttctgctttc accaagagag tgtttcttca ctcaactcag   1140

gtggcatttg gggtgacatc tcaaaggcca ggaattccgt tgacttgttg gctgccagta   1200

ggggcgggag gaaaggcgga ggcgagccct ggaggaggga ggccacaact ccgagctgcc   1260

cacctggtgc tgagctgggg ccccgcctcc tttctgtttt atttttgagg aaataaaata   1320

accaagtgct aaatcttgta aaaaaaaaaa aa                                 1352


<210>  4017
<211>  297
<212>  PRT
<213>  Homosapiens

<400>  4017

Met Ala Ser Pro Gln Leu Cys Arg Ala Leu Val Ser Ala Gln Trp Val 
1               5                   10                  15      


Ala Glu Ala Leu Arg Ala Pro Arg Ala Gly Gln Pro Leu Gln Leu Leu 
            20                  25                  30          


Asp Ala Ser Trp Tyr Leu Pro Lys Leu Gly Arg Asp Ala Arg Arg Glu 
        35                  40                  45              


Phe Glu Glu Arg His Ile Pro Gly Ala Ala Phe Phe Asp Ile Asp Gln 
    50                  55                  60                  


Cys Ser Asp Arg Thr Ser Pro Tyr Asp His Met Leu Pro Gly Ala Glu 
65                  70                  75                  80  


His Phe Ala Glu Tyr Ala Gly Arg Leu Gly Val Gly Ala Ala Thr His 
                85                  90                  95      


Val Val Ile Tyr Asp Ala Ser Asp Gln Gly Leu Tyr Ser Ala Pro Arg 
            100                 105                 110         


Val Trp Trp Met Phe Arg Ala Phe Gly His His Ala Val Ser Leu Leu 
        115                 120                 125             


Asp Gly Gly Leu Arg His Trp Leu Arg Gln Asn Leu Pro Leu Ser Ser 
    130                 135                 140                 


Gly Lys Ser Gln Pro Ala Pro Ala Glu Phe Arg Ala Gln Leu Asp Pro 
145                 150                 155                 160 


Ala Phe Ile Lys Thr Tyr Glu Asp Ile Lys Glu Asn Leu Glu Ser Arg 
                165                 170                 175     


Arg Phe Gln Val Val Asp Ser Arg Ala Thr Gly Arg Phe Arg Gly Thr 
            180                 185                 190         


Glu Pro Glu Pro Arg Asp Gly Ile Glu Pro Gly His Ile Pro Gly Thr 
        195                 200                 205             


Val Asn Ile Pro Phe Thr Asp Phe Leu Ser Gln Glu Gly Leu Glu Lys 
    210                 215                 220                 


Ser Pro Glu Glu Ile Arg His Leu Phe Gln Glu Lys Lys Val Asp Leu 
225                 230                 235                 240 


Ser Lys Pro Leu Val Ala Thr Cys Gly Ser Gly Val Thr Ala Cys His 
                245                 250                 255     


Val Ala Leu Gly Ala Tyr Leu Cys Gly Lys Pro Asp Val Pro Ile Tyr 
            260                 265                 270         


Asp Gly Ser Trp Val Glu Trp Tyr Met Arg Ala Arg Pro Glu Asp Val 
        275                 280                 285             


Ile Ser Glu Gly Arg Gly Lys Thr His 
    290                 295         


<210>  4018
<211>  1626
<212>  DNA
<213>  Homosapiens

<400>  4018
gggcggagcg ggcgtacccc cacggcccgg ccagtggaag gcgcgggcag cagcggctcc     60

gagtggccgc ggcggtgggc tgtgccggag tctcctccct ttggtccgct gcaggttggt    120

ggcgggagga ggggacagct gcgggcgcgg ggagggggcg ccgcgccgcg ggggccatgg    180

cggagccagg aagccgggag tccgagaccc gggtcgccaa tataaatgct tgatgagtga    240

atgaatgact tccgtctggg acttggttgc aaataaagcc gagctgcatc ttagggaggg    300

gtggagactt tgcccctgtt tgtgccttga agccagcagg gccttgccct aggatacctc    360

cacccaccct cctgcccagc aagtggaggc ccgcagcccg agtgtcgccg ccatggcttc    420

gccgcagctc tgccgcgcgc tggtgtcggc gcaatgggtg gcggaggcgc tgcgggcccc    480

gcgcgctggg cagcctctgc agctgctgga cgcctcctgg tacctgccga agctggggcg    540

cgacgcgcga cgcgagttcg aggagcgcca catcccgggc gccgctttct tcgacatcga    600

ccagtgcagc gaccgcacct cgccctacga ccacatgctg cccggggccg agcatttcgc    660

ggagtacgca ggccgcctgg gcgtgggcgc ggccacccac gtcgtgatct acgacgccag    720

cgaccagggc ctctactccg ccccgcgcgt ctggtggatg ttccgcgcct tcggccacca    780

cgccgtgtca ctgcttgatg gcggcctccg ccactggctg cgccagaacc tcccgctcag    840

ctccggcaag agccaacctg ctcccgccga gttccgcgct cagctcgacc ccgccttcat    900

caagacctac gaggacatca aggagaacct ggaatcccgg cgcttccagg tggtggactc    960

ccgagccact ggcaggttcc gcggcaccga gcccgagccc cgagacggca ttgaacctgg   1020

ccacatccca ggtaccgtga acatcccctt cacagacttc ctgagccagg aggggctgga   1080

gaagagccct gaggagatcc gccatctgtt ccaggagaag aaagtggacc tgtctaagcc   1140

actggtggcc acgtgtggct ctggcgtcac agcctgccac gtggcactag gggcctacct   1200

ctgcggcaag ccagacgtgc ccatctacga tggctcctgg gtggagtggt acatgcgcgc   1260

ccggcccgag gatgtcatct cagagggccg ggggaagacc cactgaagct gggcaggaca   1320

caggcgagct caggtgatgc cggccaccag caatgcctgg cctggtagct ccgcttctgc   1380

tttcaccaag agagtgtttc ttcactcaac tcaggtggca tttggggtga catctcaaag   1440

gccaggaatt ccgttgactt gttggctgcc agtaggggcg ggaggaaagg cggaggcgag   1500

ccctggagga gggaggccac aactccgagc tgcccacctg gtgctgagct ggggccccgc   1560

ctcctttctg ttttattttt gaggaaataa aataaccaag tgctaaatct tgtaaaaaaa   1620

aaaaaa                                                              1626


<210>  4019
<211>  297
<212>  PRT
<213>  Homosapiens

<400>  4019

Met Ala Ser Pro Gln Leu Cys Arg Ala Leu Val Ser Ala Gln Trp Val 
1               5                   10                  15      


Ala Glu Ala Leu Arg Ala Pro Arg Ala Gly Gln Pro Leu Gln Leu Leu 
            20                  25                  30          


Asp Ala Ser Trp Tyr Leu Pro Lys Leu Gly Arg Asp Ala Arg Arg Glu 
        35                  40                  45              


Phe Glu Glu Arg His Ile Pro Gly Ala Ala Phe Phe Asp Ile Asp Gln 
    50                  55                  60                  


Cys Ser Asp Arg Thr Ser Pro Tyr Asp His Met Leu Pro Gly Ala Glu 
65                  70                  75                  80  


His Phe Ala Glu Tyr Ala Gly Arg Leu Gly Val Gly Ala Ala Thr His 
                85                  90                  95      


Val Val Ile Tyr Asp Ala Ser Asp Gln Gly Leu Tyr Ser Ala Pro Arg 
            100                 105                 110         


Val Trp Trp Met Phe Arg Ala Phe Gly His His Ala Val Ser Leu Leu 
        115                 120                 125             


Asp Gly Gly Leu Arg His Trp Leu Arg Gln Asn Leu Pro Leu Ser Ser 
    130                 135                 140                 


Gly Lys Ser Gln Pro Ala Pro Ala Glu Phe Arg Ala Gln Leu Asp Pro 
145                 150                 155                 160 


Ala Phe Ile Lys Thr Tyr Glu Asp Ile Lys Glu Asn Leu Glu Ser Arg 
                165                 170                 175     


Arg Phe Gln Val Val Asp Ser Arg Ala Thr Gly Arg Phe Arg Gly Thr 
            180                 185                 190         


Glu Pro Glu Pro Arg Asp Gly Ile Glu Pro Gly His Ile Pro Gly Thr 
        195                 200                 205             


Val Asn Ile Pro Phe Thr Asp Phe Leu Ser Gln Glu Gly Leu Glu Lys 
    210                 215                 220                 


Ser Pro Glu Glu Ile Arg His Leu Phe Gln Glu Lys Lys Val Asp Leu 
225                 230                 235                 240 


Ser Lys Pro Leu Val Ala Thr Cys Gly Ser Gly Val Thr Ala Cys His 
                245                 250                 255     


Val Ala Leu Gly Ala Tyr Leu Cys Gly Lys Pro Asp Val Pro Ile Tyr 
            260                 265                 270         


Asp Gly Ser Trp Val Glu Trp Tyr Met Arg Ala Arg Pro Glu Asp Val 
        275                 280                 285             


Ile Ser Glu Gly Arg Gly Lys Thr His 
    290                 295         


<210>  4020
<211>  1450
<212>  DNA
<213>  Homosapiens

<400>  4020
gggcggagcg ggcgtacccc cacggcccgg ccagtggaag gcgcgggcag cagcggctcc     60

gagtggccgc ggcggtgggc tgtgccggag tctcctccct ttggtccgct gcaggttggt    120

ggcgggagga ggggacagct gcgggcgcgg ggagggggcg ccgcgccgcg ggggccatgg    180

cggagccagg aagccgggag tccgagaccc gggcccgcag cccgagtgtc gccgccatgg    240

cttcgccgca gctctgccgc gcgctggtgt cggcgcaatg ggtggcggag gcgctgcggg    300

ccccgcgcgc tgggcagcct ctgcagctgc tggacgcctc ctggtacctg ccgaagctgg    360

ggcgcgacgc gcgacgcgag ttcgaggagc gccacatccc gggcgccgct ttcttcgaca    420

tcgaccagtg cagcgaccgc acctcgccct acgaccacat gctgcccggg gccgagcatt    480

tcgcggagta cgcaggccgc ctgggcgtgg gcgcggccac ccacgtcgtg atctacgacg    540

ccagcgacca gggcctctac tccgccccgc gcgtctggtg gatgttccgc gccttcggcc    600

accacgccgt gtcactgctt gatggcggcc tccgccactg gctgcgccag aacctcccgc    660

tcagctccgg caagagccaa cctgctcccg ccgagttccg cgctcagctc gaccccgcct    720

tcatcaagac ctacgaggac atcaaggaga acctggaatc ccggcgcttc caggtggtgg    780

actcccgagc cactggcagg ttccgcggca ccgagcccga gccccgagac ggcattgaac    840

ctggccacat cccaggtacc gtgaacatcc ccttcacaga cttcctgagc caggaggggc    900

tggagaagag ccctgaggag atccgccatc tgttccagga gaagaaagtg gacctgtcta    960

agccactggt ggccacgtgt ggctctggcg tcacagcctg ccacgtggca ctaggggcct   1020

acctctgcgg caagccagac gtgcccatct acgatggctc ctgggtggag tggtacatgc   1080

gcgcccggcc cgaggatgtc atctcagagg gccgggggaa gacccactga agctgggcag   1140

gacacaggcg agctcaggtg atgccggcca ccagcaatgc ctggcctggt agctccgctt   1200

ctgctttcac caagagagtg tttcttcact caactcaggt ggcatttggg gtgacatctc   1260

aaaggccagg aattccgttg acttgttggc tgccagtagg ggcgggagga aaggcggagg   1320

cgagccctgg aggagggagg ccacaactcc gagctgccca cctggtgctg agctggggcc   1380

ccgcctcctt tctgttttat ttttgaggaa ataaaataac caagtgctaa atcttgtaaa   1440

aaaaaaaaaa                                                          1450


<210>  4021
<211>  297
<212>  PRT
<213>  Homosapiens

<400>  4021

Met Ala Ser Pro Gln Leu Cys Arg Ala Leu Val Ser Ala Gln Trp Val 
1               5                   10                  15      


Ala Glu Ala Leu Arg Ala Pro Arg Ala Gly Gln Pro Leu Gln Leu Leu 
            20                  25                  30          


Asp Ala Ser Trp Tyr Leu Pro Lys Leu Gly Arg Asp Ala Arg Arg Glu 
        35                  40                  45              


Phe Glu Glu Arg His Ile Pro Gly Ala Ala Phe Phe Asp Ile Asp Gln 
    50                  55                  60                  


Cys Ser Asp Arg Thr Ser Pro Tyr Asp His Met Leu Pro Gly Ala Glu 
65                  70                  75                  80  


His Phe Ala Glu Tyr Ala Gly Arg Leu Gly Val Gly Ala Ala Thr His 
                85                  90                  95      


Val Val Ile Tyr Asp Ala Ser Asp Gln Gly Leu Tyr Ser Ala Pro Arg 
            100                 105                 110         


Val Trp Trp Met Phe Arg Ala Phe Gly His His Ala Val Ser Leu Leu 
        115                 120                 125             


Asp Gly Gly Leu Arg His Trp Leu Arg Gln Asn Leu Pro Leu Ser Ser 
    130                 135                 140                 


Gly Lys Ser Gln Pro Ala Pro Ala Glu Phe Arg Ala Gln Leu Asp Pro 
145                 150                 155                 160 


Ala Phe Ile Lys Thr Tyr Glu Asp Ile Lys Glu Asn Leu Glu Ser Arg 
                165                 170                 175     


Arg Phe Gln Val Val Asp Ser Arg Ala Thr Gly Arg Phe Arg Gly Thr 
            180                 185                 190         


Glu Pro Glu Pro Arg Asp Gly Ile Glu Pro Gly His Ile Pro Gly Thr 
        195                 200                 205             


Val Asn Ile Pro Phe Thr Asp Phe Leu Ser Gln Glu Gly Leu Glu Lys 
    210                 215                 220                 


Ser Pro Glu Glu Ile Arg His Leu Phe Gln Glu Lys Lys Val Asp Leu 
225                 230                 235                 240 


Ser Lys Pro Leu Val Ala Thr Cys Gly Ser Gly Val Thr Ala Cys His 
                245                 250                 255     


Val Ala Leu Gly Ala Tyr Leu Cys Gly Lys Pro Asp Val Pro Ile Tyr 
            260                 265                 270         


Asp Gly Ser Trp Val Glu Trp Tyr Met Arg Ala Arg Pro Glu Asp Val 
        275                 280                 285             


Ile Ser Glu Gly Arg Gly Lys Thr His 
    290                 295         


<210>  4022
<211>  1854
<212>  DNA
<213>  Homosapiens

<400>  4022
agactgcggg cctgcgggga agggcgaagc ggggcgggac cgggggcggg agcagcgcgg     60

ggcgggaccc tacccgcggc ccacgcggag ccaggaggcg cggactacag ctcccggcct    120

gccccgcgtg cggtccccgc ccgcccccag cgcccgggag gaggatgcag acgccgcggc    180

cggcgatgag gatggaggcc ggggaggcag cgccgccggc gggggcgggc ggccgcgccg    240

caggcggctg gggcaagtgg gtgcggctca acgtgggggg cacggtgttc ctgaccaccc    300

ggcagacgct gtgccgcgag cagaagtcct tcctcagccg cctgtgccag ggggaagagc    360

tgcagtcgga ccgggatgag accggggcct acctcattga ccgtgacccc acctacttcg    420

ggcccatcct gaacttcctc cggcatggca agctggtgct ggacaaggac atggctgagg    480

agggggtcct ggaggaagcc gagttctaca acatcggccc gctgatccgc atcatcaaag    540

accggatgga agagaaggac tacacggtca cccaggtccc acccaagcac gtgtaccgcg    600

tgctgcagtg ccaggaggag gagctcacgc aaatggtctc caccatgtct gatggctggc    660

gcttcgagca gctggtgaac atcggctcct cctacaacta cggcagcgag gaccaggcag    720

agttcctgtg tgtggtgtcc aaggagctcc acagcacccc aaacgggctg agctcagagt    780

ccagccgcaa aaccaagagc acggaggagc agctggagga gcagcagcag caggaggagg    840

aggtggagga ggtggaggtg gaacaggtgc aggtggaggc agatgcacag gagaaaggtt    900

cccgtccgca ccctctcaga cctgaggctg agcttgcagt gagggcttct cctcggcccc    960

tcgcccgccc ccagagctgc catccctgct gttacaagcc agaggcaccc ggatgtgagg   1020

ccccagatca cctccaggga cttggggttc ccatctgaaa tcctttattt ttgtaccatg   1080

gggtgggccc cgggcctgag aaggaagaag caccctctcc ccggcctcct ctgtctgcac   1140

ccgtggggct gtgacttact cctgcctcca ggggcggggc ggggcccccc tgggacctct   1200

taaggcccaa ggtgggcccc aggacctctg ggcagagtgg actgctcatg gcagatgtgt   1260

ggcaatgtct ggctgtgtct ctccggcacc tgcgtcccct ctcccgggct cccctgctgc   1320

atggtggatg tgctccttcc tggcccggtc acattgcctc cttgagcctt agtccagggg   1380

gtcactcctc ccaccccacc tacctcacag ggttgttgtg agggtgcaca gaggagcaaa   1440

gtccctgaag gccctcaggc agtatatagg ggccgcccac cttcagctgc cctgggatgg   1500

gaaggaccca gcccgacccc tgggcataac actgtgtttg caaatggaga ttcaggtatt   1560

ggggatgcag gttgtgggga gctggcctgg cagagtaggg gtagttggct tggccttctc   1620

tttggtgatc ccacccccag ccatttgcat tgctggccca gcgcctggcc tggggggcgg   1680

ggagaggcag cagaaggggc tgggcagggg cggtggagga ctcaggaact gcccggggag   1740

agtgggtatg gcggctgagc caggggccct cctgtgtttg acttcccggg atgggtcctt   1800

gcttctcagc tgtgtccgac cccaccatgt aataaaaccc aaaggaacag ccca         1854


<210>  4023
<211>  290
<212>  PRT
<213>  Homosapiens

<400>  4023

Met Arg Met Glu Ala Gly Glu Ala Ala Pro Pro Ala Gly Ala Gly Gly 
1               5                   10                  15      


Arg Ala Ala Gly Gly Trp Gly Lys Trp Val Arg Leu Asn Val Gly Gly 
            20                  25                  30          


Thr Val Phe Leu Thr Thr Arg Gln Thr Leu Cys Arg Glu Gln Lys Ser 
        35                  40                  45              


Phe Leu Ser Arg Leu Cys Gln Gly Glu Glu Leu Gln Ser Asp Arg Asp 
    50                  55                  60                  


Glu Thr Gly Ala Tyr Leu Ile Asp Arg Asp Pro Thr Tyr Phe Gly Pro 
65                  70                  75                  80  


Ile Leu Asn Phe Leu Arg His Gly Lys Leu Val Leu Asp Lys Asp Met 
                85                  90                  95      


Ala Glu Glu Gly Val Leu Glu Glu Ala Glu Phe Tyr Asn Ile Gly Pro 
            100                 105                 110         


Leu Ile Arg Ile Ile Lys Asp Arg Met Glu Glu Lys Asp Tyr Thr Val 
        115                 120                 125             


Thr Gln Val Pro Pro Lys His Val Tyr Arg Val Leu Gln Cys Gln Glu 
    130                 135                 140                 


Glu Glu Leu Thr Gln Met Val Ser Thr Met Ser Asp Gly Trp Arg Phe 
145                 150                 155                 160 


Glu Gln Leu Val Asn Ile Gly Ser Ser Tyr Asn Tyr Gly Ser Glu Asp 
                165                 170                 175     


Gln Ala Glu Phe Leu Cys Val Val Ser Lys Glu Leu His Ser Thr Pro 
            180                 185                 190         


Asn Gly Leu Ser Ser Glu Ser Ser Arg Lys Thr Lys Ser Thr Glu Glu 
        195                 200                 205             


Gln Leu Glu Glu Gln Gln Gln Gln Glu Glu Glu Val Glu Glu Val Glu 
    210                 215                 220                 


Val Glu Gln Val Gln Val Glu Ala Asp Ala Gln Glu Lys Gly Ser Arg 
225                 230                 235                 240 


Pro His Pro Leu Arg Pro Glu Ala Glu Leu Ala Val Arg Ala Ser Pro 
                245                 250                 255     


Arg Pro Leu Ala Arg Pro Gln Ser Cys His Pro Cys Cys Tyr Lys Pro 
            260                 265                 270         


Glu Ala Pro Gly Cys Glu Ala Pro Asp His Leu Gln Gly Leu Gly Val 
        275                 280                 285             


Pro Ile 
    290 


<210>  4024
<211>  3212
<212>  DNA
<213>  Homosapiens

<400>  4024
cttgagccag acccagtcca gctctggtgc ctgccctctg gtgcgagctg acctgagatg     60

cacttccctc ctctgtgagc tgtctcggca cccacttgca gtcactgccg cctgatgttg    120

ttactcttcc actccaaaag gatgcccgtg gccgaggccc cccaggtggc tggcgggcag    180

ggggacggag gtgatggcga ggaagcggag ccggagggga tgttcaaggc ctgtgaggac    240

tccaagagaa aagcccgggg ctacctccgc ctggtgcccc tgtttgtgct gctggccctg    300

ctcgtgctgg cttcggcggg ggtgctactc tggtatttcc tagggtacaa ggcggaggtg    360

atggtcagcc aggtgtactc aggcagtctg cgtgtactca atcgccactt ctcccaggat    420

cttacccgcc gggaatctag tgccttccgc agtgaaaccg ccaaagccca gaagatgctc    480

aaggagctca tcaccagcac ccgcctggga acttactaca actccagctc cgtctattcc    540

tttggggagg gacccctcac ctgcttcttc tggttcattc tccaaatccc cgagcaccgc    600

cggctgatgc tgagccccga ggtggtgcag gcactgctgg tggaggagct gctgtccaca    660

gtcaacagct cggctgccgt cccctacagg gccgagtacg aagtggaccc cgagggccta    720

gtgatcctgg aagccagtgt gaaagacata gctgcattga attccacgct gggttgttac    780

cgctacagct acgtgggcca gggccaggtc ctccggctga aggggcctga ccacctggcc    840

tccagctgcc tgtggcacct gcagggcccc aaggacctca tgctcaaact ccggctggag    900

tggacgctgg cagagtgccg ggaccgactg gccatgtatg acgtggccgg gcccctggag    960

aagaggctca tcacctcggt gtacggctgc agccgccagg agcccgtggt ggaggttctg   1020

gcgtcggggg ccatcatggc ggtcgtctgg aagaagggcc tgcacagcta ctacgacccc   1080

ttcgtgctct ccgtgcagcc ggtggtcttc caggcctgtg aagtgaacct gacgctggac   1140

aacaggctcg actcccaggg cgtcctcagc accccgtact tccccagcta ctactcgccc   1200

caaacccact gctcctggca cctcacggtg ccctctctgg actacggctt ggccctctgg   1260

tttgatgcct atgcactgag gaggcagaag tatgatttgc cgtgcaccca gggccagtgg   1320

acgatccaga acaggaggct gtgtggcttg cgcatcctgc agccctacgc cgagaggatc   1380

cccgtggtgg ccacggccgg gatcaccatc aacttcacct cccagatctc cctcaccggg   1440

cccggtgtgc gggtgcacta tggcttgtac aaccagtcgg acccctgccc tggagagttc   1500

ctctgttctg tgaatggact ctgtgtccct gcctgtgatg gggtcaagga ctgccccaac   1560

ggcctggatg agagaaactg cgtttgcaga gccacattcc agtgcaaaga ggacagcaca   1620

tgcatctcac tgcccaaggt ctgtgatggg cagcctgatt gtctcaacgg cagcgacgaa   1680

gagcagtgcc aggaaggggt gccatgtggg acattcacct tccagtgtga ggaccggagc   1740

tgcgtgaaga agcccaaccc gcagtgtgat gggcggcccg actgcaggga cggctcggat   1800

gaggagcact gtgactgtgg cctccagggc ccctccagcc gcattgttgg tggagctgtg   1860

tcctccgagg gtgagtggcc atggcaggcc agcctccagg ttcggggtcg acacatctgt   1920

gggggggccc tcatcgctga ccgctgggtg ataacagctg cccactgctt ccaggaggac   1980

agcatggcct ccacggtgct gtggaccgtg ttcctgggca aggtgtggca gaactcgcgc   2040

tggcctggag aggtgtcctt caaggtgagc cgcctgctcc tgcacccgta ccacgaagag   2100

gacagccatg actacgacgt ggcgctgctg cagctcgacc acccggtggt gcgctcggcc   2160

gccgtgcgcc ccgtctgcct gcccgcgcgc tcccacttct tcgagcccgg cctgcactgc   2220

tggattacgg gctggggcgc cttgcgcgag ggcggcccca tcagcaacgc tctgcagaaa   2280

gtggatgtgc agttgatccc acaggacctg tgcagcgagg tctatcgcta ccaggtgacg   2340

ccacgcatgc tgtgtgccgg ctaccgcaag ggcaagaagg atgcctgtca gggtgactca   2400

ggtggtccgc tggtgtgcaa ggcactcagt ggccgctggt tcctggcggg gctggtcagc   2460

tggggcctgg gctgtggccg gcctaactac ttcggcgtct acacccgcat cacaggtgtg   2520

atcagctgga tccagcaagt ggtgacctga ggaactgccc ccctgcaaag cagggcccac   2580

ctcctggact cagagagccc agggcaactg ccaagcaggg ggacaagtat tctggcgggg   2640

ggtgggggag agagcaggcc ctgtggtggc aggaggtggc atcttgtctc gtccctgatg   2700

tctgctccag tgatggcagg aggatggaga agtgccagca gctgggggtc aagacgtccc   2760

ctgaggaccc aggcccacac ccagcccttc tgcctcccaa ttctctctcc tccgtcccct   2820

tcctccactg ctgcctaatg caaggcagtg gctcagcagc aagaatgctg gttctacatc   2880

ccgaggagtg tctgaggtgc gccccactct gtacagaggc tgtttgggca gccttgcctc   2940

cagagagcag attccagctt cggaagcccc tggtctaact tgggatctgg gaatggaagg   3000

tgctcccatc ggaggggacc ctcagagccc tggagactgc caggtgggcc tgctgccact   3060

gtaagccaaa aggtggggaa gtcctgactc cagggtcctt gccccacccc tgcctgccac   3120

ctgggccctc acagcccaga ccctcactgg gaggtgagct cagctgccct ttggaataaa   3180

gctgcctgat caaaaaaaaa aaaaaaaaaa aa                                 3212


<210>  4025
<211>  811
<212>  PRT
<213>  Homosapiens

<400>  4025

Met Leu Leu Leu Phe His Ser Lys Arg Met Pro Val Ala Glu Ala Pro 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Gly Asp Gly Gly Asp Gly Glu Glu Ala Glu 
            20                  25                  30          


Pro Glu Gly Met Phe Lys Ala Cys Glu Asp Ser Lys Arg Lys Ala Arg 
        35                  40                  45              


Gly Tyr Leu Arg Leu Val Pro Leu Phe Val Leu Leu Ala Leu Leu Val 
    50                  55                  60                  


Leu Ala Ser Ala Gly Val Leu Leu Trp Tyr Phe Leu Gly Tyr Lys Ala 
65                  70                  75                  80  


Glu Val Met Val Ser Gln Val Tyr Ser Gly Ser Leu Arg Val Leu Asn 
                85                  90                  95      


Arg His Phe Ser Gln Asp Leu Thr Arg Arg Glu Ser Ser Ala Phe Arg 
            100                 105                 110         


Ser Glu Thr Ala Lys Ala Gln Lys Met Leu Lys Glu Leu Ile Thr Ser 
        115                 120                 125             


Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr Ser Phe Gly 
    130                 135                 140                 


Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile Leu Gln Ile Pro Glu 
145                 150                 155                 160 


His Arg Arg Leu Met Leu Ser Pro Glu Val Val Gln Ala Leu Leu Val 
                165                 170                 175     


Glu Glu Leu Leu Ser Thr Val Asn Ser Ser Ala Ala Val Pro Tyr Arg 
            180                 185                 190         


Ala Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu Glu Ala Ser 
        195                 200                 205             


Val Lys Asp Ile Ala Ala Leu Asn Ser Thr Leu Gly Cys Tyr Arg Tyr 
    210                 215                 220                 


Ser Tyr Val Gly Gln Gly Gln Val Leu Arg Leu Lys Gly Pro Asp His 
225                 230                 235                 240 


Leu Ala Ser Ser Cys Leu Trp His Leu Gln Gly Pro Lys Asp Leu Met 
                245                 250                 255     


Leu Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu Cys Arg Asp Arg Leu 
            260                 265                 270         


Ala Met Tyr Asp Val Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr Ser 
        275                 280                 285             


Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Val Glu Val Leu Ala Ser 
    290                 295                 300                 


Gly Ala Ile Met Ala Val Val Trp Lys Lys Gly Leu His Ser Tyr Tyr 
305                 310                 315                 320 


Asp Pro Phe Val Leu Ser Val Gln Pro Val Val Phe Gln Ala Cys Glu 
                325                 330                 335     


Val Asn Leu Thr Leu Asp Asn Arg Leu Asp Ser Gln Gly Val Leu Ser 
            340                 345                 350         


Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Gln Thr His Cys Ser Trp 
        355                 360                 365             


His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp 
    370                 375                 380                 


Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys Thr Gln Gly 
385                 390                 395                 400 


Gln Trp Thr Ile Gln Asn Arg Arg Leu Cys Gly Leu Arg Ile Leu Gln 
                405                 410                 415     


Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Thr Ala Gly Ile Thr Ile 
            420                 425                 430         


Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Arg Val His 
        435                 440                 445             


Tyr Gly Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu Cys 
    450                 455                 460                 


Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Val Lys Asp Cys 
465                 470                 475                 480 


Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Thr Phe Gln 
                485                 490                 495     


Cys Lys Glu Asp Ser Thr Cys Ile Ser Leu Pro Lys Val Cys Asp Gly 
            500                 505                 510         


Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys Gln Glu Gly 
        515                 520                 525             


Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg Ser Cys Val 
    530                 535                 540                 


Lys Lys Pro Asn Pro Gln Cys Asp Gly Arg Pro Asp Cys Arg Asp Gly 
545                 550                 555                 560 


Ser Asp Glu Glu His Cys Asp Cys Gly Leu Gln Gly Pro Ser Ser Arg 
                565                 570                 575     


Ile Val Gly Gly Ala Val Ser Ser Glu Gly Glu Trp Pro Trp Gln Ala 
            580                 585                 590         


Ser Leu Gln Val Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile Ala 
        595                 600                 605             


Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser Met 
    610                 615                 620                 


Ala Ser Thr Val Leu Trp Thr Val Phe Leu Gly Lys Val Trp Gln Asn 
625                 630                 635                 640 


Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Leu Leu 
                645                 650                 655     


His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu Leu 
            660                 665                 670         


Gln Leu Asp His Pro Val Val Arg Ser Ala Ala Val Arg Pro Val Cys 
        675                 680                 685             


Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Leu His Cys Trp Ile 
    690                 695                 700                 


Thr Gly Trp Gly Ala Leu Arg Glu Gly Gly Pro Ile Ser Asn Ala Leu 
705                 710                 715                 720 


Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Ser Glu Val 
                725                 730                 735     


Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys 
            740                 745                 750         


Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
        755                 760                 765             


Lys Ala Leu Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly 
    770                 775                 780                 


Leu Gly Cys Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr Arg Ile Thr 
785                 790                 795                 800 


Gly Val Ile Ser Trp Ile Gln Gln Val Val Thr 
                805                 810     


<210>  4026
<211>  4045
<212>  DNA
<213>  Homosapiens

<400>  4026
gcagccagag ctcagcaggg ccctggagag atggccacgg tcccagcacc ggggaggact     60

ggagagcgcg cgctgccacc gccccatgtc tcagccaggg cttccttcct cggctccacc    120

ctgtggatgt aatggcggcc cctgctctgt cctggcgtct gcccctcctc atcctcctcc    180

tgcccctggc tacctcttgg gcatctgcag cggtgaatgg cacttcccag ttcacatgct    240

tctacaactc gagagccaac atctcctgtg tctggagcca agatggggct ctgcaggaca    300

cttcctgcca agtccatgcc tggccggaca gacggcggtg gaaccaaacc tgtgagctgc    360

tccccgtgag tcaagcatcc tgggcctgca acctgatcct cggagcccca gattctcaga    420

aactgaccac agttgacatc gtcaccctga gggtgctgtg ccgtgagggg gtgcgatgga    480

gggtgatggc catccaggac ttcaagccct ttgagaacct tcgcctgatg gcccccatct    540

ccctccaagt tgtccacgtg gagacccaca gatgcaacat aagctgggaa atctcccaag    600

cctcccacta ctttgaaaga cacctggagt tcgaggcccg gacgctgtcc ccaggccaca    660

cctgggagga ggcccccctg ctgactctca agcagaagca ggaatggatc tgcctggaga    720

cgctcacccc agacacccag tatgagtttc aggtgcgggt caagcctctg caaggcgagt    780

tcacgacctg gagcccctgg agccagcccc tggccttcag gacaaagcct gcagcccttg    840

ggaaggacac cattccgtgg ctcggccacc tcctcgtggg cctcagcggg gcttttggct    900

tcatcatctt agtgtacttg ctgatcaact gcaggaacac cgggccatgg ctgaagaagg    960

tcctgaagtg taacacccca gacccctcga agttcttttc ccagctgagc tcagagcatg   1020

gaggagacgt ccagaagtgg ctctcttcgc ccttcccctc atcgtccttc agccctggcg   1080

gcctggcacc tgagatctcg ccactagaag tgctggagag ggacaaggtg acgcagctgc   1140

tcctgcagca ggacaaggtg cctgagcccg catccttaag cagcaaccac tcgctgacca   1200

gctgcttcac caaccagggt tacttcttct tccacctccc ggatgccttg gagatagagg   1260

cctgccaggt gtactttact tacgacccct actcagagga agaccctgat gagggtgtgg   1320

ccggggcacc cacagggtct tccccccaac ccctgcagcc tctgtcaggg gaggacgacg   1380

cctactgcac cttcccctcc agggatgacc tgctgctctt ctcccccagt ctcctcggtg   1440

gccccagccc cccaagcact gcccctgggg gcagtggggc cggtgaagag aggatgcccc   1500

cttctttgca agaaagagtc cccagagact gggaccccca gcccctgggg cctcccaccc   1560

caggagtccc agacctggtg gattttcagc caccccctga gctggtgctg cgagaggctg   1620

gggaggaggt ccctgacgct ggccccaggg agggagtcag tttcccctgg tccaggcctc   1680

ctgggcaggg ggagttcagg gcccttaatg ctcgcctgcc cctgaacact gatgcctact   1740

tgtccctcca agaactccag ggtcaggacc caactcactt ggtgtagaca gatggccagg   1800

gtgggaggca ggcagctgcc tgctctgcgc cgagcctcag aaggaccctg ttgagggtcc   1860

tcagtccact gctgaggaca ctcagtgtcc agttgcagct ggacttctcc acccggatgg   1920

cccccaccca gtcctgcaca cttggtccat ccatttccaa acctccactg ctgctcccgg   1980

gtcctgctgc ccgagccagg aactgtgtgt gttgcagggg ggcagtaact ccccaactcc   2040

ctcgttaatc acaggatccc acgaatttag gctcagaagc atcgctcctc tccagccctg   2100

cagctattca ccaatatcag tcctcgcggc tctccagggc tccctgccct gacctcttcc   2160

ctgggttttc tgccccagcc tcctccttcc ctcccctccc cgtccacagg gcagcctgag   2220

cgtgctttcc aaaacccaaa tatggccacg ctccccctcg gttcaaaacc ttgcacaggt   2280

cccactgccc tcagccccac ttctcagcct ggtacttgta cctccggtgt cgtgtgggga   2340

catccccttc tgcaatcctc cctaccgtcc tcctgagcca ctcagagctc cctcacaccc   2400

cctctgttgc acatgctatt ccctggggct gctgtgcgct ccccctcatc taggtgacaa   2460

acttccctga ctcttcaagt gccggttttg cttctcctgg agggaagcac tgcctccctt   2520

aatctgccag aaacttctag cgtcagtgct ggagggagaa gctgtcaggg acccagggcg   2580

cctggagaaa gaggccctgt tactattcct ttgggatctc tgaggcctca gagtgcttgg   2640

ctgctgtatc tttaatgctg gggcccaagt aagggcacag atccccccac aaagtggatg   2700

cctgctgcat cttcccacag tggcttcaca gacccacaag agaagctgat ggggagtaaa   2760

ccctggagtc cgaggcccag gcagcagccc cgcctagtgg tgggccctga tgctgccagg   2820

cctgggacct cccactgccc cctccactgg aggggtctcc tctgcagctc agggactggc   2880

acactggcct ccagaagggc agctccacag ggcagggcct cattattttt cactgcccca   2940

gacacagtgc ccaacacccc gtcgtatacc ctggatgaac gaattaatta cctggcacca   3000

cctcgtctgg gctccctgcg cctgacattc acacagagag gcagagtccc gtgcccatta   3060

ggtctggcat gccccctcct gcaaggggct caacccccta ccccgacccc tccacgtatc   3120

tttcctaggc agatcacgtt gcaatggctc aaacaacatt ccaccccagc aggacagtga   3180

ccccagtccc agctaactct gacctgggag ccctcaggca cctgcactta caggccttgc   3240

tcacagctga ttgggcacct gaccacacgc ccccacaggc tctgaccagc agcctatgag   3300

ggggtttggc accaagctct gtccaatcag gtaggctggg cctgaactag ccaatcagat   3360

caactctgtc ttgggcgttt gaactcaggg agggaggccc ttgggagcag gtgcttgtgg   3420

acaaggctcc acaagcgttg agccttggaa aggtagacaa gcgttgagcc actaagcaga   3480

ggaccttggg ttcccaatac aaaaatacct actgctgaga gggctgctga ccatttggtc   3540

aggattcctg ttgcctttat atccaaaata aactcccctt tcttgaggtt gtctgagtct   3600

tgggtctatg ccttgaaaaa agctgaatta ttggacagtc tcacctcctg ccatagggtc   3660

ctgaatgttt cagaccacaa ggggctccac acctttgctg tgtgttctgg ggcaacctac   3720

taatcctctc tgcaagtcgg tctccttatc cccccaaatg gaaattgtat ttgccttctc   3780

cactttggga ggctcccact tcttgggagg gttacatttt ttaagtctta atcatttgtg   3840

acatatgtat ctatacatcc gtatctttta atgatccgtg tgtaccatct ttgtgattat   3900

ttccttaata ttttttcttt aagtcagttc attttcgttg aaatacattt atttaaagaa   3960

aaatctttgt tactctgtaa atgaaaaaac ccattttcgc tataaataaa aggtaactgt   4020

acaaaataag tacaatgcaa caaaa                                         4045


<210>  4027
<211>  551
<212>  PRT
<213>  Homosapiens

<400>  4027

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
            340                 345                 350         


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
            500                 505                 510         


Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  4028
<211>  2954
<212>  DNA
<213>  Homosapiens

<400>  4028
tccctcctct gctgggcctg ggggtctggg ccagcaacaa gttagtattg cagacatggg     60

ccaaggagcc agaggccatg cagtggctca gggtccgtga gtcgcctggg gaggccacag    120

gacacagggt caccatgggg acagccgccc tgggtcccgt ctgggcagcg ctcctgctct    180

ttctcctgat gtgtgagatc cctatggtgg agctcacctt tgacagagct gtggccagcg    240

gctgccaacg gtgctgtgac tctgaggacc ccctggatcc tgcccatgta tcctcagcct    300

cttcctccgg ccgcccccac gccctgcctg agatcagacc ctacattaat atcaccatcc    360

tgaagggtga caaaggggac ccaggcccaa tgggcctgcc agggtacatg ggcagggagg    420

gtccccaagg ggagcctggc cctcagggca gcaagggtga caagggggag atgggcagcc    480

ccggcgcccc gtgccagaag cgcttcttcg ccttctcagt gggccgcaag acggccctgc    540

acagcggcga ggacttccag acgctgctct tcgaaagggt ctttgtgaac cttgatgggt    600

gctttgacat ggcgaccggc cagtttgctg ctcccctgcg tggcatctac ttcttcagcc    660

tcaatgtgca cagctggaat tacaaggaga cgtacgtgca cattatgcat aaccagaaag    720

aggctgtcat cctgtacgcg cagcccagcg agcgcagcat catgcagagc cagagtgtga    780

tgctggacct ggcctacggg gaccgcgtct gggtgcggct cttcaagcgc cagcgcgaga    840

acgccatcta cagcaacgac ttcgacacct acatcacctt cagcggccac ctcatcaagg    900

ccgaggacga ctgagggcct ctgggccacc ctcccggctg gagagctcag gtgctggtcc    960

cgtcccctgc agggctcagt ttgcactgct gtgaagcagg aaggccaggg aggtccccgg   1020

ggacctggca ttctggggag accctgcttc tatcttggct gccatcatcc ctcccagcct   1080

atttctgctc ctctcttctc tcttggacct attttaagaa gcttgctaac ctaaatattc   1140

tagaactttc ccagcctcgt agcccagcac ttctcaaact tggaaatgca tgcgaatcac   1200

ccggggttcg tgttaaatgc agattctgac tcagcaggtc tgagtgggtc caggattctg   1260

tgtttctcat atgttcctgg gtgatgctga tggggtcagt ctatgaacca cactggagca   1320

accaggttct aggactttct caatattcta gtactttctg aacattctgg aatcctcccc   1380

acattctaga attctcccaa catttttttt tcttgagaca gagtcttgct ctgttgccca   1440

ggctagagtg cagtggtgca atctcagttc actgcaacct ctgcctcccg ggttcaagcg   1500

attcttctgc ctcagcctcc ctagtggctg ggattacagg cgcctgctac catgcctggc   1560

taatttttgt atttttagta gagatggggt ttcaccatat tggccaggct ggtcttgaac   1620

tcctgacttc aggtgaccca cccgcctcgg cctctcaaaa tgctgggatt acaggtgtga   1680

gccaccgtgc ctggccaatt ccaacattct taaattctct catccctcca gggctccccg   1740

tgctatgttc tctttacccc ttccccctct tctcttgctc aggcctgcac cactgcagcc   1800

accgttcatt tattcattca ttaaacactg agcactcact ctgtgctggg tcccgggaag   1860

ggtgaggggg tcagacacag gccctgcccc tgccctcagt gactggccag tccagcccag   1920

gcggggagag atgtgtacat aggttttaaa gcagacccag agctcatggg ggcctgtgtt   1980

ctgggtgttc aggtgctgct ggtcctccat tacccactgc tccccaaggc tggtgggacg   2040

gggtcccggt ggcaggggca ggtatctcct tcccgttcct catccacctg cccagtgctc   2100

atcgttacag caaaccccag ggggccttgg ccaggtcaag ggttctgtga ggagaggacc   2160

caggagtgtg ggggcatttg gggggtgaag tggcccccga agaatggaac ccacacccat   2220

agctctcccc acagctgata cggcatcctg cgagaagacc tgccctcctc actgggatcc   2280

ccttcctgcc tcctcccagg gctctgccag ggccttgctc agtcccttcc accaaagtca   2340

tctgaacttc cgtttcccca gggcctccag ctgccctcag acactgatgt ctgtccccag   2400

gtgctctctg cccctcatgc ccctctcacc ggcccagtgc cccgactctc caggctttat   2460

caaggtgcta aggcccgggt gggcagctcc tcgtctcaga gccctcctcc ggcctggtgc   2520

tgcctttaca aacacctgca ggagaagggc cacggaagcc ccaggcttta gagccctcag   2580

caggtctggg gagctagagc aaaggaggga cctcaggcct tccgtttctt cttccagggt   2640

ggggtggcct ggtgttcccc tagccttcca aacccaggtg gcctgccctt ctccccagag   2700

ggaggcggcc tccgcccatt ggtgctcatg cagactctgg ggctgaggtg ccccgggggg   2760

tgatctctgg tgctcacagc cgaggagccg tggctccatg gccagatgac ggaaacaggg   2820

tctgaccaag tgccaggaag acctgtgcta taaaccaccc tgcctgatcc tgcccctgcc   2880

tgaccccgcc acgccctgcc gtccagcatg attaaagaat gctgtctcct cttggcaaaa   2940

aaaaaaaaaa aaaa                                                     2954


<210>  4029
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  4029

Met Gln Trp Leu Arg Val Arg Glu Ser Pro Gly Glu Ala Thr Gly His 
1               5                   10                  15      


Arg Val Thr Met Gly Thr Ala Ala Leu Gly Pro Val Trp Ala Ala Leu 
            20                  25                  30          


Leu Leu Phe Leu Leu Met Cys Glu Ile Pro Met Val Glu Leu Thr Phe 
        35                  40                  45              


Asp Arg Ala Val Ala Ser Gly Cys Gln Arg Cys Cys Asp Ser Glu Asp 
    50                  55                  60                  


Pro Leu Asp Pro Ala His Val Ser Ser Ala Ser Ser Ser Gly Arg Pro 
65                  70                  75                  80  


His Ala Leu Pro Glu Ile Arg Pro Tyr Ile Asn Ile Thr Ile Leu Lys 
                85                  90                  95      


Gly Asp Lys Gly Asp Pro Gly Pro Met Gly Leu Pro Gly Tyr Met Gly 
            100                 105                 110         


Arg Glu Gly Pro Gln Gly Glu Pro Gly Pro Gln Gly Ser Lys Gly Asp 
        115                 120                 125             


Lys Gly Glu Met Gly Ser Pro Gly Ala Pro Cys Gln Lys Arg Phe Phe 
    130                 135                 140                 


Ala Phe Ser Val Gly Arg Lys Thr Ala Leu His Ser Gly Glu Asp Phe 
145                 150                 155                 160 


Gln Thr Leu Leu Phe Glu Arg Val Phe Val Asn Leu Asp Gly Cys Phe 
                165                 170                 175     


Asp Met Ala Thr Gly Gln Phe Ala Ala Pro Leu Arg Gly Ile Tyr Phe 
            180                 185                 190         


Phe Ser Leu Asn Val His Ser Trp Asn Tyr Lys Glu Thr Tyr Val His 
        195                 200                 205             


Ile Met His Asn Gln Lys Glu Ala Val Ile Leu Tyr Ala Gln Pro Ser 
    210                 215                 220                 


Glu Arg Ser Ile Met Gln Ser Gln Ser Val Met Leu Asp Leu Ala Tyr 
225                 230                 235                 240 


Gly Asp Arg Val Trp Val Arg Leu Phe Lys Arg Gln Arg Glu Asn Ala 
                245                 250                 255     


Ile Tyr Ser Asn Asp Phe Asp Thr Tyr Ile Thr Phe Ser Gly His Leu 
            260                 265                 270         


Ile Lys Ala Glu Asp Asp 
        275             


<210>  4030
<211>  1670
<212>  DNA
<213>  Homosapiens

<400>  4030
tccctcctct gctgggcctg ggggtctggg ccagcaacaa gttagtattg cagacatggg     60

ccaaggagcc agaggccatg cagtggctca gggtccgtga gtcgcctggg gaggccacag    120

gacacagggt caccatgggg acagccgccc tgggtcccgt ctgggcagcg ctcctgctct    180

ttctcctgat gtgtgagatc cctatggtgg agctcacctt tgacagagct gtggccagcg    240

gctgccaacg gtgctgtgac tctgaggacc ccctggatcc tgcccatgta tcctcagcct    300

cttcctccgg ccgcccccac gccctgcctg agatcagacc ctacattaat atcaccatcc    360

tgaagggtga caaaggggac ccaggcccaa tgggcctgcc agggtacatg ggcagggagg    420

gtccccaagg ggagcctggc cctcagggca gcaagggtga caagggggag atgggcagcc    480

ccggcgcccc gtgccagaag cgcttcttcg ccttctcagt gggccgcaag acggccctgc    540

acagcggcga ggacttccag acgctgctct tcgaaagggt ctttgtgaac cttgatgggt    600

gctttgacat ggcgaccggc cagtttgctg ctcccctgcg tggcatctac ttcttcagcc    660

tcaatgtgca cagctggaat tacaaggaga cgtacgtgca cattatgcat aaccagaaag    720

aggctgtcat cctgtacgcg cagcccagcg agcgcagcat catgcagagc cagagtgtga    780

tgctggacct ggcctacggg gaccgcgtct gggtgcggct cttcaagcgc cagcgcgaga    840

acgccatcta cagcaacgac ttcgacacct acatcacctt cagcggccac ctcatcaagg    900

ccgaggacga ctgagggcct ctgggccacc ctcccggctg gagagctcag ctgatacggc    960

atcctgcgag aagacctgcc ctcctcactg ggatcccctt cctgcctcct cccagggctc   1020

tgccagggcc ttgctcagtc ccttccacca aagtcatctg aacttccgtt tccccagggc   1080

ctccagctgc cctcagacac tgatgtctgt ccccaggtgc tctctgcccc tcatgcccct   1140

ctcaccggcc cagtgccccg actctccagg ctttatcaag gtgctaaggc ccgggtgggc   1200

agctcctcgt ctcagagccc tcctccggcc tggtgctgcc tttacaaaca cctgcaggag   1260

aagggccacg gaagccccag gctttagagc cctcagcagg tctggggagc tagagcaaag   1320

gagggacctc aggccttccg tttcttcttc cagggtgggg tggcctggtg ttcccctagc   1380

cttccaaacc caggtggcct gcccttctcc ccagagggag gcggcctccg cccattggtg   1440

ctcatgcaga ctctggggct gaggtgcccc ggggggtgat ctctggtgct cacagccgag   1500

gagccgtggc tccatggcca gatgacggaa acagggtctg accaagtgcc aggaagacct   1560

gtgctataaa ccaccctgcc tgatcctgcc cctgcctgac cccgccacgc cctgccgtcc   1620

agcatgatta aagaatgctg tctcctcttg gcaaaaaaaa aaaaaaaaaa              1670


<210>  4031
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  4031

Met Gln Trp Leu Arg Val Arg Glu Ser Pro Gly Glu Ala Thr Gly His 
1               5                   10                  15      


Arg Val Thr Met Gly Thr Ala Ala Leu Gly Pro Val Trp Ala Ala Leu 
            20                  25                  30          


Leu Leu Phe Leu Leu Met Cys Glu Ile Pro Met Val Glu Leu Thr Phe 
        35                  40                  45              


Asp Arg Ala Val Ala Ser Gly Cys Gln Arg Cys Cys Asp Ser Glu Asp 
    50                  55                  60                  


Pro Leu Asp Pro Ala His Val Ser Ser Ala Ser Ser Ser Gly Arg Pro 
65                  70                  75                  80  


His Ala Leu Pro Glu Ile Arg Pro Tyr Ile Asn Ile Thr Ile Leu Lys 
                85                  90                  95      


Gly Asp Lys Gly Asp Pro Gly Pro Met Gly Leu Pro Gly Tyr Met Gly 
            100                 105                 110         


Arg Glu Gly Pro Gln Gly Glu Pro Gly Pro Gln Gly Ser Lys Gly Asp 
        115                 120                 125             


Lys Gly Glu Met Gly Ser Pro Gly Ala Pro Cys Gln Lys Arg Phe Phe 
    130                 135                 140                 


Ala Phe Ser Val Gly Arg Lys Thr Ala Leu His Ser Gly Glu Asp Phe 
145                 150                 155                 160 


Gln Thr Leu Leu Phe Glu Arg Val Phe Val Asn Leu Asp Gly Cys Phe 
                165                 170                 175     


Asp Met Ala Thr Gly Gln Phe Ala Ala Pro Leu Arg Gly Ile Tyr Phe 
            180                 185                 190         


Phe Ser Leu Asn Val His Ser Trp Asn Tyr Lys Glu Thr Tyr Val His 
        195                 200                 205             


Ile Met His Asn Gln Lys Glu Ala Val Ile Leu Tyr Ala Gln Pro Ser 
    210                 215                 220                 


Glu Arg Ser Ile Met Gln Ser Gln Ser Val Met Leu Asp Leu Ala Tyr 
225                 230                 235                 240 


Gly Asp Arg Val Trp Val Arg Leu Phe Lys Arg Gln Arg Glu Asn Ala 
                245                 250                 255     


Ile Tyr Ser Asn Asp Phe Asp Thr Tyr Ile Thr Phe Ser Gly His Leu 
            260                 265                 270         


Ile Lys Ala Glu Asp Asp 
        275             


<210>  4032
<211>  2123
<212>  DNA
<213>  Homosapiens

<400>  4032
cgcatctctc atcactcccc ctcattctgc ctttcctcct actcacggtc tcctctccct     60

ctccctctct ctctctcccc ctccctcttt ctctctctct ctctttctcc acctcctccc    120

gacccccttt cccctctatt tctattggct tctgtgtccc ttgctcccct cttctcttcc    180

tcaccctggg aagcttctcc cccctatcct tgcccctgcc cccccaggat gtgtcctgga    240

gatggggggt gacgtaccag gctctggttg ggaagtcagg gccggagacc agatgggaga    300

ggctctgtgg acagccgtgg ccgagggcct gggagggaac ctgagcccgc aagcggtcta    360

gaagtgggtg ccgtgtgggg accctagtta ggagtgccct gggggcacct ggggactggg    420

cagggagagg ggacagcaga atgataacca gcctggcggc aaggagggaa gccctcaccc    480

catgggcagg caaatagctg actgctgacc accctcccct cagccatgga catgcttcat    540

ccatcatcgg tgtccacgac ctcagaacct gagaatgcct cctcggcctg gcccccagat    600

gccaccctgg gcaacgtgtc ggcgggccca agcccggcag ggctggccgt cagtggcgtt    660

ctgatccccc tggtctacct ggtggtgtgc gtggtgggcc tgctgggtaa ctcgctggtc    720

atctatgtgg tcctgcggca cacggccagc ccttcagtca ccaacgtcta catcctcaac    780

ctggcgctgg ccgacgagct cttcatgctg gggctgccct tcctggccgc ccagaacgcc    840

ctgtcctact ggcccttcgg ctccctcatg tgccgcctgg tcatggcggt ggatggcatc    900

aaccagttca ccagcatatt ctgcctgact gtcatgagcg tggaccgcta cctggccgtg    960

gtacatccca cccgctcggc ccgctggcgc acagctccgg tggcccgcac ggtcagcgcg   1020

gctgtgtggg tggcctcagc cgtggtggtg ctgcccgtgg tggtcttctc gggagtgccc   1080

cgcggcatga gcacctgcca catgcagtgg cccgagccgg cggcggcctg gcgagccggc   1140

ttcatcatct acacggccgc actgggcttc ttcgggccgc tgctggtcat ctgcctctgc   1200

tacctgctca tcgtggtgaa ggtgcgctca gctgggcgcc gggtgtgggc accctcgtgc   1260

cagcggcggc ggcgctccga acgcagggtc acgcgcatgg tggtggccgt ggtggcgctc   1320

ttcgtgctct gctggatgcc cttctacgtg ctcaacatcg tcaacgtggt gtgcccactg   1380

cccgaggagc ctgccttctt tgggctctac ttcctggtgg tggcgctgcc ctatgccaac   1440

agctgtgcca accccatcct ttatggcttc ctctcctacc gcttcaagca gggcttccgc   1500

agggtcctgc tgcggccctc ccgccgtgtg cgcagccagg agcccactgt ggggcccccg   1560

gagaagactg aggaggagga tgaggaggag gaggatgggg aggagagcag ggaggggggc   1620

aaggggaagg agatgaacgg ccgggtcagc cagatcacgc agcctggcac cagcgggcag   1680

gagcggccgc ccagcagagt ggccagcaag gagcagcagc tcctacccca agaggcttcc   1740

actggggaga agtccagcac gatgcgcatc agctacctgt agggcctggg gaaagccagg   1800

atggcccgag gaagaggcag aagccgtggg tgtgcctagg gcctacttcc caaggtgcca   1860

caggcccatg atgggatgtt gaggggcctg gactttgatg ctattgctgc caggtcttgc   1920

tgtgtgacct tgggtaggtt gcttctactc tctgggcctt gttttctcct ctgtgactca   1980

gggataggag tcatcagcct ggatgagcta tgtcagatga gaggtttgga gggcactgtt   2040

gctgggctga cctggctgag caggcaaaag gtgggtgcag actggcctcc ccccagggat   2100

ggagtgtctt ggggcatcaa cta                                           2123


<210>  4033
<211>  418
<212>  PRT
<213>  Homosapiens

<400>  4033

Met Asp Met Leu His Pro Ser Ser Val Ser Thr Thr Ser Glu Pro Glu 
1               5                   10                  15      


Asn Ala Ser Ser Ala Trp Pro Pro Asp Ala Thr Leu Gly Asn Val Ser 
            20                  25                  30          


Ala Gly Pro Ser Pro Ala Gly Leu Ala Val Ser Gly Val Leu Ile Pro 
        35                  40                  45              


Leu Val Tyr Leu Val Val Cys Val Val Gly Leu Leu Gly Asn Ser Leu 
    50                  55                  60                  


Val Ile Tyr Val Val Leu Arg His Thr Ala Ser Pro Ser Val Thr Asn 
65                  70                  75                  80  


Val Tyr Ile Leu Asn Leu Ala Leu Ala Asp Glu Leu Phe Met Leu Gly 
                85                  90                  95      


Leu Pro Phe Leu Ala Ala Gln Asn Ala Leu Ser Tyr Trp Pro Phe Gly 
            100                 105                 110         


Ser Leu Met Cys Arg Leu Val Met Ala Val Asp Gly Ile Asn Gln Phe 
        115                 120                 125             


Thr Ser Ile Phe Cys Leu Thr Val Met Ser Val Asp Arg Tyr Leu Ala 
    130                 135                 140                 


Val Val His Pro Thr Arg Ser Ala Arg Trp Arg Thr Ala Pro Val Ala 
145                 150                 155                 160 


Arg Thr Val Ser Ala Ala Val Trp Val Ala Ser Ala Val Val Val Leu 
                165                 170                 175     


Pro Val Val Val Phe Ser Gly Val Pro Arg Gly Met Ser Thr Cys His 
            180                 185                 190         


Met Gln Trp Pro Glu Pro Ala Ala Ala Trp Arg Ala Gly Phe Ile Ile 
        195                 200                 205             


Tyr Thr Ala Ala Leu Gly Phe Phe Gly Pro Leu Leu Val Ile Cys Leu 
    210                 215                 220                 


Cys Tyr Leu Leu Ile Val Val Lys Val Arg Ser Ala Gly Arg Arg Val 
225                 230                 235                 240 


Trp Ala Pro Ser Cys Gln Arg Arg Arg Arg Ser Glu Arg Arg Val Thr 
                245                 250                 255     


Arg Met Val Val Ala Val Val Ala Leu Phe Val Leu Cys Trp Met Pro 
            260                 265                 270         


Phe Tyr Val Leu Asn Ile Val Asn Val Val Cys Pro Leu Pro Glu Glu 
        275                 280                 285             


Pro Ala Phe Phe Gly Leu Tyr Phe Leu Val Val Ala Leu Pro Tyr Ala 
    290                 295                 300                 


Asn Ser Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu Ser Tyr Arg Phe 
305                 310                 315                 320 


Lys Gln Gly Phe Arg Arg Val Leu Leu Arg Pro Ser Arg Arg Val Arg 
                325                 330                 335     


Ser Gln Glu Pro Thr Val Gly Pro Pro Glu Lys Thr Glu Glu Glu Asp 
            340                 345                 350         


Glu Glu Glu Glu Asp Gly Glu Glu Ser Arg Glu Gly Gly Lys Gly Lys 
        355                 360                 365             


Glu Met Asn Gly Arg Val Ser Gln Ile Thr Gln Pro Gly Thr Ser Gly 
    370                 375                 380                 


Gln Glu Arg Pro Pro Ser Arg Val Ala Ser Lys Glu Gln Gln Leu Leu 
385                 390                 395                 400 


Pro Gln Glu Ala Ser Thr Gly Glu Lys Ser Ser Thr Met Arg Ile Ser 
                405                 410                 415     


Tyr Leu 
        


<210>  4034
<211>  1516
<212>  DNA
<213>  Homosapiens

<400>  4034
tgccccacca ccgctgctcc tcagcaggcg cctcaccagc ctccacaccc cttgcgcccg     60

cagaaacgcg cctggccctg agctgtcacc accgacactc tccaggctcc ggacacgatg    120

caggccatca agtgtgtggt ggtgggagat ggggccgtgg gcaagacctg ccttctcatc    180

agctacacca ccaacgcctt tcccggagag tacatcccca ccgtgtttga caactattca    240

gccaatgtga tggtggacag caagccagtg aacctggggc tgtgggacac tgctgggcag    300

gaggactacg accgtctccg gccgctctcc tatccacaga cggacgtctt cctcatctgc    360

ttctccctcg tcagcccagc ctcttatgag aacgtccgcg ccaagtggtt cccagaagtg    420

cggcaccact gccccagcac acccatcatc ctggtgggca ccaagctgga cctgcgggac    480

gacaaggaca ccatcgagaa actgaaggag aagaagctgg ctcccatcac ctacccgcag    540

ggcctggcac tggccaagga gattgactcg gtgaaatacc tggagtgctc agctctcacc    600

cagagaggcc tgaaaaccgt gttcgacgag gccatccggg ccgtgctgtg ccctcagccc    660

acgcggcagc agaagcgcgc ctgcagcctc ctctaggggt tgcaccccag cgctcccacc    720

tagatgggtc tgatcctcca ggatccccac ccaaagcctg atggcacccc ggctggccat    780

gctgtcccct ccctgtggcg tttcttagca gatggctgca gagcttcgtt gatggtcttt    840

tctgtactgg aggcctcctg aggccaggaa cgtgcaaatt tgcaggtgct gcatcccaag    900

cccctcatgc tcctgccttc ctgagggcca gaggggagcc ccaggaccca ttaagccacc    960

cccgtgttcc tgccgtcagt gccaactgcc gcatgtggaa gcatctaccc gttcactcca   1020

gtcccacccc acgcctgact cccctctgga aactgcaggc cagatggttg ctgccacaac   1080

ttgtgtacct tcagggatgg ggctcttact ccctcctgag gccagctgct ctaatatcga   1140

tggtcctgct tgccagagag ttcctctacc cagcaaaaat gagtgtctca gaagtgtgct   1200

cctctggcct cagttctcct cttttggaac aacataaaac aaatttaatt ttctacgcct   1260

ctggggatat ctgctcagcc aatggaaaat ctgggttcaa ccagcccctg ccatttctta   1320

agactttctg ctgcactcac aggatcctga gctgcactta cctgtgagag tcttcaaact   1380

tttaaacctt gccagtcagg acttttgcta ttgcaaatag aaaacccaac tcaacctgct   1440

taagcagaaa ataaatttat tgattcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1500

aaaaaaaaaa aaaaaa                                                   1516


<210>  4035
<211>  192
<212>  PRT
<213>  Homosapiens

<400>  4035

Met Gln Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30          


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Ser 
        35                  40                  45              


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80  


Cys Phe Ser Leu Val Ser Pro Ala Ser Tyr Glu Asn Val Arg Ala Lys 
                85                  90                  95      


Trp Phe Pro Glu Val Arg His His Cys Pro Ser Thr Pro Ile Ile Leu 
            100                 105                 110         


Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu Lys 
        115                 120                 125             


Leu Lys Glu Lys Lys Leu Ala Pro Ile Thr Tyr Pro Gln Gly Leu Ala 
    130                 135                 140                 


Leu Ala Lys Glu Ile Asp Ser Val Lys Tyr Leu Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val 
                165                 170                 175     


Leu Cys Pro Gln Pro Thr Arg Gln Gln Lys Arg Ala Cys Ser Leu Leu 
            180                 185                 190         


<210>  4036
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  4036
ggacagcgcc gaggaggaag aggttgatgg cggcggcgga gctccgagag acctcggctg     60

ggcaggggcc ggccgtggcg ggccggggac tgcgcctcta gagccgcgag ttctcgggaa    120

ttcgccgcag cggacgcgct cggcgaattt gtgctcttgt gccctcctcc gggcttgggc    180

ccaggcccgg cccctcgcac ttgcccttac cttttctatc gagtccgcat ccctctccag    240

ccactgcgac ccggcgaaga gaaaaaggaa cttcccccac cccctcgggt gccgtcggag    300

ccccccagcc cacccctggg tgcggcgcgg ggaccccggg ccgaagaaga gatttcctga    360

ggattctggt tttcctcgct tgtatctccg aaagaattaa aaatggccga gaatgtggtg    420

gaaccggggc cgccttcagc caagcggcct aaactctcat ctccggccct ctcggcgtcc    480

gccagcgatg gcacagattt tggctctcta tttgacttgg agcacgactt accagatgaa    540

ttaatcaact ctacagaatt gggactaacc aatggtggtg atattaatca gcttcagaca    600

agtcttggca tggtacaaga tgcagcttct aaacataaac agctgtcaga attgctgcga    660

tctggtagtt cccctaacct caatatggga gttggtggcc caggtcaagt catggccagc    720

caggcccaac agagcagtcc tggattaggt ttgataaata gcatggtcaa aagcccaatg    780

acacaggcag gcttgacttc tcccaacatg gggatgggca ctagtggacc aaatcagggt    840

cctacgcagt caacaggtat gatgaacagt ccagtaaatc agcctgccat gggaatgaac    900

acagggatga atgcgggcat gaatcctgga atgttggctg caggcaatgg acaagggata    960

atgcctaatc aagtcatgaa cggttcaatt ggagcaggcc gagggcgaca gaatatgcag   1020

tacccaaacc caggcatggg aagtgctggc aacttactga ctgagcctct tcagcagggc   1080

tctccccaga tgggaggaca aacaggattg agaggccccc agcctcttaa gatgggaatg   1140

atgaacaacc ccaatcctta tggttcacca tatactcaga atcctggaca gcagattgga   1200

gccagtggcc ttggtctcca gattcagaca aaaactgtac tatcaaataa cttatctcca   1260

tttgctatgg acaaaaaggc agttcctggt ggaggaatgc ccaacatggg tcaacagcca   1320

gccccgcagg tccagcagcc aggcctggtg actccagttg cccaagggat gggttctgga   1380

gcacatacag ctgatccaga gaagcgcaag ctcatccagc agcagcttgt tctccttttg   1440

catgctcaca agtgccagcg ccgggaacag gccaatgggg aagtgaggca gtgcaacctt   1500

ccccactgtc gcacaatgaa gaatgtccta aaccacatga cacactgcca gtcaggcaag   1560

tcttgccaag tggcacactg tgcatcttct cgacaaatca tttcacactg gaagaattgt   1620

acaagacatg attgtcctgt gtgtctcccc ctcaaaaatg ctggtgataa gagaaatcaa   1680

cagccaattt tgactggagc acccgttgga cttggaaatc ctagctctct aggggtgggt   1740

caacagtctg cccccaacct aagcactgtt agtcagattg atcccagctc catagaaaga   1800

gcctatgcag ctcttggact accctatcaa gtaaatcaga tgccgacaca accccaggtg   1860

caagcaaaga accagcagaa tcagcagcct gggcagtctc cccaaggcat gcggcccatg   1920

agcaacatga gtgctagtcc tatgggagta aatggaggtg taggagttca aacgccgagt   1980

cttctttctg actcaatgtt gcattcagcc ataaattctc aaaacccaat gatgagtgaa   2040

aatgccagtg tgccctccct gggtcctatg ccaacagcag ctcaaccatc cactactgga   2100

attcggaaac agtggcacga agatattact caggatcttc gaaatcatct tgttcacaaa   2160

ctcgtccaag ccatatttcc tacgccggat cctgctgctt taaaagacag acggatggaa   2220

aacctagttg catatgctcg gaaagttgaa ggggacatgt atgaatctgc aaacaatcga   2280

gcggaatact accaccttct agctgagaaa atctataaga tccagaaaga actagaagaa   2340

aaacgaagga ccagactaca gaagcagaac atgctaccaa atgctgcagg catggttcca   2400

gtttccatga atccagggcc taacatggga cagccgcaac caggaatgac ttctaatggc   2460

cctctacctg acccaagtat gatccgtggc agtgtgccaa accagatgat gcctcgaata   2520

actccacaat ctggtttgaa tcaatttggc cagatgagca tggcccagcc ccctattgta   2580

ccccggcaaa cccctcctct tcagcaccat ggacagttgg ctcaacctgg agctctcaac   2640

ccgcctatgg gctatgggcc tcgtatgcaa cagccttcca accagggcca gttccttcct   2700

cagactcagt tcccatcaca gggaatgaat gtaacaaata tccctttggc tccgtccagc   2760

ggtcaagctc cagtgtctca agcacaaatg tctagttctt cctgcccggt gaactctcct   2820

ataatgcctc cagggtctca ggggagccac attcactgtc cccagcttcc tcaaccagct   2880

cttcatcaga attcaccctc gcctgtacct agtcgtaccc ccacccctca ccatactccc   2940

ccaagcatag gggctcagca gccaccagca acaacaattc cagcccctgt tcctacacct   3000

cctgccatgc cacctgggcc acagtcccag gctctacatc cccctccaag gcagacacct   3060

acaccaccaa caacacaact tccccaacaa gtgcagcctt cacttcctgc tgcaccttct   3120

gctgaccagc cccagcagca gcctcgctca cagcagagca cagcagcgtc tgttcctacc   3180

ccaacagcac cgctgcttcc tccgcagcct gcaactccac tttcccagcc agctgtaagc   3240

attgaaggac aggtatcaaa tcctccatct actagtagca cagaagtgaa ttctcaggcc   3300

attgctgaga agcagccttc ccaggaagtg aagatggagg ccaaaatgga agtggatcaa   3360

ccagaaccag cagatactca gccggaggat atttcagagt ctaaagtgga agactgtaaa   3420

atggaatcta ccgaaacaga agagagaagc actgagttaa aaactgaaat aaaagaggag   3480

gaagaccagc caagtacttc agctacccag tcatctccgg ctccaggaca gtcaaagaaa   3540

aagattttca aaccagaaga actacgacag gcactgatgc caactttgga ggcactttac   3600

cgtcaggatc cagaatccct tccctttcgt caacctgtgg accctcagct tttaggaatc   3660

cctgattact ttgatattgt gaagagcccc atggatcttt ctaccattaa gaggaagtta   3720

gacactggac agtatcagga gccctggcag tatgtcgatg atatttggct tatgttcaat   3780

aatgcctggt tatataaccg gaaaacatca cgggtataca aatactgctc caagctctct   3840

gaggtctttg aacaagaaat tgacccagtg atgcaaagcc ttggatactg ttgtggcaga   3900

aagttggagt tctctccaca gacactgtgt tgctacggca aacagttgtg cacaatacct   3960

cgtgatgcca cttattacag ttaccagaac aggtatcatt tctgtgagaa gtgtttcaat   4020

gagatccaag gggagagcgt ttctttgggg gatgaccctt cccagcctca aactacaata   4080

aataaagaac aattttccaa gagaaaaaat gacacactgg atcctgaact gtttgttgaa   4140

tgtacagagt gcggaagaaa gatgcatcag atctgtgtcc ttcaccatga gatcatctgg   4200

cctgctggat tcgtctgtga tggctgttta aagaaaagtg cacgaactag gaaagaaaat   4260

aagttttctg ctaaaaggtt gccatctacc agacttggca cctttctaga gaatcgtgtg   4320

aatgactttc tgaggcgaca gaatcaccct gagtcaggag aggtcactgt tagagtagtt   4380

catgcttctg acaaaaccgt ggaagtaaaa ccaggcatga aagcaaggtt tgtggacagt   4440

ggagagatgg cagaatcctt tccataccga accaaagccc tctttgcctt tgaagaaatt   4500

gatggtgttg acctgtgctt ctttggcatg catgttcaag agtatggctc tgactgccct   4560

ccacccaacc agaggagagt atacatatct tacctcgata gtgttcattt cttccgtcct   4620

aaatgcttga ggactgcagt ctatcatgaa atcctaattg gatatttaga atatgtcaag   4680

aaattaggtt acacaacagg gcatatttgg gcatgtccac caagtgaggg agatgattat   4740

atcttccatt gccatcctcc tgaccagaag atacccaagc ccaagcgact gcaggaatgg   4800

tacaaaaaaa tgcttgacaa ggctgtatca gagcgtattg tccatgacta caaggatatt   4860

tttaaacaag ctactgaaga tagattaaca agtgcaaagg aattgcctta tttcgagggt   4920

gatttctggc ccaatgttct ggaagaaagc attaaggaac tggaacagga ggaagaagag   4980

agaaaacgag aggaaaacac cagcaatgaa agcacagatg tgaccaaggg agacagcaaa   5040

aatgctaaaa agaagaataa taagaaaacc agcaaaaata agagcagcct gagtaggggc   5100

aacaagaaga aacccgggat gcccaatgta tctaacgacc tctcacagaa actatatgcc   5160

accatggaga agcataaaga ggtcttcttt gtgatccgcc tcattgctgg ccctgctgcc   5220

aactccctgc ctcccattgt tgatcctgat cctctcatcc cctgcgatct gatggatggt   5280

cgggatgcgt ttctcacgct ggcaagggac aagcacctgg agttctcttc actccgaaga   5340

gcccagtggt ccaccatgtg catgctggtg gagctgcaca cgcagagcca ggaccgcttt   5400

gtctacacct gcaatgaatg caagcaccat gtggagacac gctggcactg tactgtctgt   5460

gaggattatg acttgtgtat cacctgctat aacactaaaa accatgacca caaaatggag   5520

aaactaggcc ttggcttaga tgatgagagc aacaaccagc aggctgcagc cacccagagc   5580

ccaggcgatt ctcgccgcct gagtatccag cgctgcatcc agtctctggt ccatgcttgc   5640

cagtgtcgga atgccaattg ctcactgcca tcctgccaga agatgaagcg ggttgtgcag   5700

cataccaagg gttgcaaacg gaaaaccaat ggcgggtgcc ccatctgcaa gcagctcatt   5760

gccctctgct gctaccatgc caagcactgc caggagaaca aatgcccggt gccgttctgc   5820

ctaaacatca agcagaagct ccggcagcaa cagctgcagc accgactaca gcaggcccaa   5880

atgcttcgca ggaggatggc cagcatgcag cggactggtg tggttgggca gcaacagggc   5940

ctcccttccc ccactcctgc cactccaacg acaccaactg gccaacagcc aaccaccccg   6000

cagacgcccc agcccacttc tcagcctcag cctacccctc ccaatagcat gccaccctac   6060

ttgcccagga ctcaagctgc tggccctgtg tcccagggta aggcagcagg ccaggtgacc   6120

cctccaaccc ctcctcagac tgctcagcca ccccttccag ggcccccacc tgcagcagtg   6180

gaaatggcaa tgcagattca gagagcagcg gagacgcagc gccagatggc ccacgtgcaa   6240

atttttcaaa ggccaatcca acaccagatg cccccgatga ctcccatggc ccccatgggt   6300

atgaacccac ctcccatgac cagaggtccc agtgggcatt tggagccagg gatgggaccg   6360

acagggatgc agcaacagcc accctggagc caaggaggat tgcctcagcc ccagcaacta   6420

cagtctggga tgccaaggcc agccatgatg tcagtggccc agcatggtca acctttgaac   6480

atggctccac aaccaggatt gggccaggta ggtatcagcc cactcaaacc aggcactgtg   6540

tctcaacaag ccttacaaaa ccttttgcgg actctcaggt ctcccagctc tcccctgcag   6600

cagcaacagg tgcttagtat ccttcacgcc aacccccagc tgttggctgc attcatcaag   6660

cagcgggctg ccaagtatgc caactctaat ccacaaccca tccctgggca gcctggcatg   6720

ccccaggggc agccagggct acagccacct accatgccag gtcagcaggg ggtccactcc   6780

aatccagcca tgcagaacat gaatccaatg caggcgggcg ttcagagggc tggcctgccc   6840

cagcagcaac cacagcagca actccagcca cccatgggag ggatgagccc ccaggctcag   6900

cagatgaaca tgaaccacaa caccatgcct tcacaattcc gagacatctt gagacgacag   6960

caaatgatgc aacagcagca gcaacaggga gcagggccag gaataggccc tggaatggcc   7020

aaccataacc agttccagca accccaagga gttggctacc caccacagca gcagcagcgg   7080

atgcagcatc acatgcaaca gatgcaacaa ggaaatatgg gacagatagg ccagcttccc   7140

caggccttgg gagcagaggc aggtgccagt ctacaggcct atcagcagcg actccttcag   7200

caacagatgg ggtcccctgt tcagcccaac cccatgagcc cccagcagca tatgctccca   7260

aatcaggccc agtccccaca cctacaaggc cagcagatcc ctaattctct ctccaatcaa   7320

gtgcgctctc cccagcctgt cccttctcca cggccacagt cccagccccc ccactccagt   7380

ccttccccaa ggatgcagcc tcagccttct ccacaccacg tttccccaca gacaagttcc   7440

ccacatcctg gactggtagc tgcccaggcc aaccccatgg aacaagggca ttttgccagc   7500

ccggaccaga attcaatgct ttctcagctt gctagcaatc caggcatggc aaacctccat   7560

ggtgcaagcg ccacggacct gggactcagc accgataact cagacttgaa ttcaaacctc   7620

tcacagagta cactagacat acactagaga caccttgtag tattttggga gcaaaaaaat   7680

tattttctct taacaagact ttttgtactg aaaacaattt ttttgaatct ttcgtagcct   7740

aaaagacaat tttccttgga acacataaga actgtgcagt agccgtttgt ggtttaaagc   7800

aaacatgcaa gatgaacctg agggatgata gaatacaaag aatatatttt tgttatggct   7860

ggttaccacc agcctttctt cccctttgtg tgtgtggttc aagtgtgcac tgggaggagg   7920

ctgaggcctg tgaagccaaa caatatgctc ctgccttgca cctccaatag gttttattat   7980

tttttttaaa ttaatgaaca tatgtaatat taatagttat tatttactgg tgcagatggt   8040

tgacattttt ccctattttc ctcactttat ggaagagtta aaacatttct aaaccagagg   8100

acaaaagggg ttaatgttac tttaaaatta cattctatat atatataaat atatataaat   8160

atatattaaa ataccagttt tttttctctg gg                                 8192


<210>  4037
<211>  2414
<212>  PRT
<213>  Homosapiens

<400>  4037

Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro 
1               5                   10                  15      


Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp 
            20                  25                  30          


Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile 
        35                  40                  45              


Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu 
    50                  55                  60                  


Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln 
65                  70                  75                  80  


Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly 
                85                  90                  95      


Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser 
            100                 105                 110         


Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln 
        115                 120                 125             


Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn 
    130                 135                 140                 


Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln 
145                 150                 155                 160 


Pro Ala Met Gly Met Asn Thr Gly Met Asn Ala Gly Met Asn Pro Gly 
                165                 170                 175     


Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met 
            180                 185                 190         


Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asn Met Gln Tyr Pro 
        195                 200                 205             


Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln 
    210                 215                 220                 


Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln 
225                 230                 235                 240 


Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro 
                245                 250                 255     


Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu 
            260                 265                 270         


Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala 
        275                 280                 285             


Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln 
    290                 295                 300                 


Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala 
305                 310                 315                 320 


Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys 
                325                 330                 335     


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
            340                 345                 350         


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His 
        355                 360                 365             


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser 
    370                 375                 380                 


Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
385                 390                 395                 400 


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
                405                 410                 415     


Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly 
            420                 425                 430         


Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln 
        435                 440                 445             


Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile 
    450                 455                 460                 


Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met 
465                 470                 475                 480 


Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro 
                485                 490                 495     


Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser 
            500                 505                 510         


Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu 
        515                 520                 525             


Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met 
    530                 535                 540                 


Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala 
545                 550                 555                 560 


Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr 
                565                 570                 575     


Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe 
            580                 585                 590         


Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu 
        595                 600                 605             


Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn 
    610                 615                 620                 


Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile 
625                 630                 635                 640 


Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn 
                645                 650                 655     


Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly 
            660                 665                 670         


Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu 
        675                 680                 685             


Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro 
    690                 695                 700                 


Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met 
705                 710                 715                 720 


Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His 
                725                 730                 735     


Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly 
            740                 745                 750         


Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr 
        755                 760                 765             


Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro 
    770                 775                 780                 


Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser 
785                 790                 795                 800 


Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His 
                805                 810                 815     


Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro 
            820                 825                 830         


Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser 
        835                 840                 845             


Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro 
    850                 855                 860                 


Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro 
865                 870                 875                 880 


Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln 
                885                 890                 895     


Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln 
            900                 905                 910         


Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Thr 
        915                 920                 925             


Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala 
    930                 935                 940                 


Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr 
945                 950                 955                 960 


Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val 
                965                 970                 975     


Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr 
            980                 985                 990         


Gln Pro Glu Asp Ile Ser Glu Ser  Lys Val Glu Asp Cys  Lys Met Glu 
        995                 1000                 1005             


Ser Thr  Glu Thr Glu Glu Arg  Ser Thr Glu Leu Lys  Thr Glu Ile 
    1010                 1015                 1020             


Lys Glu  Glu Glu Asp Gln Pro  Ser Thr Ser Ala Thr  Gln Ser Ser 
    1025                 1030                 1035             


Pro Ala  Pro Gly Gln Ser Lys  Lys Lys Ile Phe Lys  Pro Glu Glu 
    1040                 1045                 1050             


Leu Arg  Gln Ala Leu Met Pro  Thr Leu Glu Ala Leu  Tyr Arg Gln 
    1055                 1060                 1065             


Asp Pro  Glu Ser Leu Pro Phe  Arg Gln Pro Val Asp  Pro Gln Leu 
    1070                 1075                 1080             


Leu Gly  Ile Pro Asp Tyr Phe  Asp Ile Val Lys Ser  Pro Met Asp 
    1085                 1090                 1095             


Leu Ser  Thr Ile Lys Arg Lys  Leu Asp Thr Gly Gln  Tyr Gln Glu 
    1100                 1105                 1110             


Pro Trp  Gln Tyr Val Asp Asp  Ile Trp Leu Met Phe  Asn Asn Ala 
    1115                 1120                 1125             


Trp Leu  Tyr Asn Arg Lys Thr  Ser Arg Val Tyr Lys  Tyr Cys Ser 
    1130                 1135                 1140             


Lys Leu  Ser Glu Val Phe Glu  Gln Glu Ile Asp Pro  Val Met Gln 
    1145                 1150                 1155             


Ser Leu  Gly Tyr Cys Cys Gly  Arg Lys Leu Glu Phe  Ser Pro Gln 
    1160                 1165                 1170             


Thr Leu  Cys Cys Tyr Gly Lys  Gln Leu Cys Thr Ile  Pro Arg Asp 
    1175                 1180                 1185             


Ala Thr  Tyr Tyr Ser Tyr Gln  Asn Arg Tyr His Phe  Cys Glu Lys 
    1190                 1195                 1200             


Cys Phe  Asn Glu Ile Gln Gly  Glu Ser Val Ser Leu  Gly Asp Asp 
    1205                 1210                 1215             


Pro Ser  Gln Pro Gln Thr Thr  Ile Asn Lys Glu Gln  Phe Ser Lys 
    1220                 1225                 1230             


Arg Lys  Asn Asp Thr Leu Asp  Pro Glu Leu Phe Val  Glu Cys Thr 
    1235                 1240                 1245             


Glu Cys  Gly Arg Lys Met His  Gln Ile Cys Val Leu  His His Glu 
    1250                 1255                 1260             


Ile Ile  Trp Pro Ala Gly Phe  Val Cys Asp Gly Cys  Leu Lys Lys 
    1265                 1270                 1275             


Ser Ala  Arg Thr Arg Lys Glu  Asn Lys Phe Ser Ala  Lys Arg Leu 
    1280                 1285                 1290             


Pro Ser  Thr Arg Leu Gly Thr  Phe Leu Glu Asn Arg  Val Asn Asp 
    1295                 1300                 1305             


Phe Leu  Arg Arg Gln Asn His  Pro Glu Ser Gly Glu  Val Thr Val 
    1310                 1315                 1320             


Arg Val  Val His Ala Ser Asp  Lys Thr Val Glu Val  Lys Pro Gly 
    1325                 1330                 1335             


Met Lys  Ala Arg Phe Val Asp  Ser Gly Glu Met Ala  Glu Ser Phe 
    1340                 1345                 1350             


Pro Tyr  Arg Thr Lys Ala Leu  Phe Ala Phe Glu Glu  Ile Asp Gly 
    1355                 1360                 1365             


Val Asp  Leu Cys Phe Phe Gly  Met His Val Gln Glu  Tyr Gly Ser 
    1370                 1375                 1380             


Asp Cys  Pro Pro Pro Asn Gln  Arg Arg Val Tyr Ile  Ser Tyr Leu 
    1385                 1390                 1395             


Asp Ser  Val His Phe Phe Arg  Pro Lys Cys Leu Arg  Thr Ala Val 
    1400                 1405                 1410             


Tyr His  Glu Ile Leu Ile Gly  Tyr Leu Glu Tyr Val  Lys Lys Leu 
    1415                 1420                 1425             


Gly Tyr  Thr Thr Gly His Ile  Trp Ala Cys Pro Pro  Ser Glu Gly 
    1430                 1435                 1440             


Asp Asp  Tyr Ile Phe His Cys  His Pro Pro Asp Gln  Lys Ile Pro 
    1445                 1450                 1455             


Lys Pro  Lys Arg Leu Gln Glu  Trp Tyr Lys Lys Met  Leu Asp Lys 
    1460                 1465                 1470             


Ala Val  Ser Glu Arg Ile Val  His Asp Tyr Lys Asp  Ile Phe Lys 
    1475                 1480                 1485             


Gln Ala  Thr Glu Asp Arg Leu  Thr Ser Ala Lys Glu  Leu Pro Tyr 
    1490                 1495                 1500             


Phe Glu  Gly Asp Phe Trp Pro  Asn Val Leu Glu Glu  Ser Ile Lys 
    1505                 1510                 1515             


Glu Leu  Glu Gln Glu Glu Glu  Glu Arg Lys Arg Glu  Glu Asn Thr 
    1520                 1525                 1530             


Ser Asn  Glu Ser Thr Asp Val  Thr Lys Gly Asp Ser  Lys Asn Ala 
    1535                 1540                 1545             


Lys Lys  Lys Asn Asn Lys Lys  Thr Ser Lys Asn Lys  Ser Ser Leu 
    1550                 1555                 1560             


Ser Arg  Gly Asn Lys Lys Lys  Pro Gly Met Pro Asn  Val Ser Asn 
    1565                 1570                 1575             


Asp Leu  Ser Gln Lys Leu Tyr  Ala Thr Met Glu Lys  His Lys Glu 
    1580                 1585                 1590             


Val Phe  Phe Val Ile Arg Leu  Ile Ala Gly Pro Ala  Ala Asn Ser 
    1595                 1600                 1605             


Leu Pro  Pro Ile Val Asp Pro  Asp Pro Leu Ile Pro  Cys Asp Leu 
    1610                 1615                 1620             


Met Asp  Gly Arg Asp Ala Phe  Leu Thr Leu Ala Arg  Asp Lys His 
    1625                 1630                 1635             


Leu Glu  Phe Ser Ser Leu Arg  Arg Ala Gln Trp Ser  Thr Met Cys 
    1640                 1645                 1650             


Met Leu  Val Glu Leu His Thr  Gln Ser Gln Asp Arg  Phe Val Tyr 
    1655                 1660                 1665             


Thr Cys  Asn Glu Cys Lys His  His Val Glu Thr Arg  Trp His Cys 
    1670                 1675                 1680             


Thr Val  Cys Glu Asp Tyr Asp  Leu Cys Ile Thr Cys  Tyr Asn Thr 
    1685                 1690                 1695             


Lys Asn  His Asp His Lys Met  Glu Lys Leu Gly Leu  Gly Leu Asp 
    1700                 1705                 1710             


Asp Glu  Ser Asn Asn Gln Gln  Ala Ala Ala Thr Gln  Ser Pro Gly 
    1715                 1720                 1725             


Asp Ser  Arg Arg Leu Ser Ile  Gln Arg Cys Ile Gln  Ser Leu Val 
    1730                 1735                 1740             


His Ala  Cys Gln Cys Arg Asn  Ala Asn Cys Ser Leu  Pro Ser Cys 
    1745                 1750                 1755             


Gln Lys  Met Lys Arg Val Val  Gln His Thr Lys Gly  Cys Lys Arg 
    1760                 1765                 1770             


Lys Thr  Asn Gly Gly Cys Pro  Ile Cys Lys Gln Leu  Ile Ala Leu 
    1775                 1780                 1785             


Cys Cys  Tyr His Ala Lys His  Cys Gln Glu Asn Lys  Cys Pro Val 
    1790                 1795                 1800             


Pro Phe  Cys Leu Asn Ile Lys  Gln Lys Leu Arg Gln  Gln Gln Leu 
    1805                 1810                 1815             


Gln His  Arg Leu Gln Gln Ala  Gln Met Leu Arg Arg  Arg Met Ala 
    1820                 1825                 1830             


Ser Met  Gln Arg Thr Gly Val  Val Gly Gln Gln Gln  Gly Leu Pro 
    1835                 1840                 1845             


Ser Pro  Thr Pro Ala Thr Pro  Thr Thr Pro Thr Gly  Gln Gln Pro 
    1850                 1855                 1860             


Thr Thr  Pro Gln Thr Pro Gln  Pro Thr Ser Gln Pro  Gln Pro Thr 
    1865                 1870                 1875             


Pro Pro  Asn Ser Met Pro Pro  Tyr Leu Pro Arg Thr  Gln Ala Ala 
    1880                 1885                 1890             


Gly Pro  Val Ser Gln Gly Lys  Ala Ala Gly Gln Val  Thr Pro Pro 
    1895                 1900                 1905             


Thr Pro  Pro Gln Thr Ala Gln  Pro Pro Leu Pro Gly  Pro Pro Pro 
    1910                 1915                 1920             


Ala Ala  Val Glu Met Ala Met  Gln Ile Gln Arg Ala  Ala Glu Thr 
    1925                 1930                 1935             


Gln Arg  Gln Met Ala His Val  Gln Ile Phe Gln Arg  Pro Ile Gln 
    1940                 1945                 1950             


His Gln  Met Pro Pro Met Thr  Pro Met Ala Pro Met  Gly Met Asn 
    1955                 1960                 1965             


Pro Pro  Pro Met Thr Arg Gly  Pro Ser Gly His Leu  Glu Pro Gly 
    1970                 1975                 1980             


Met Gly  Pro Thr Gly Met Gln  Gln Gln Pro Pro Trp  Ser Gln Gly 
    1985                 1990                 1995             


Gly Leu  Pro Gln Pro Gln Gln  Leu Gln Ser Gly Met  Pro Arg Pro 
    2000                 2005                 2010             


Ala Met  Met Ser Val Ala Gln  His Gly Gln Pro Leu  Asn Met Ala 
    2015                 2020                 2025             


Pro Gln  Pro Gly Leu Gly Gln  Val Gly Ile Ser Pro  Leu Lys Pro 
    2030                 2035                 2040             


Gly Thr  Val Ser Gln Gln Ala  Leu Gln Asn Leu Leu  Arg Thr Leu 
    2045                 2050                 2055             


Arg Ser  Pro Ser Ser Pro Leu  Gln Gln Gln Gln Val  Leu Ser Ile 
    2060                 2065                 2070             


Leu His  Ala Asn Pro Gln Leu  Leu Ala Ala Phe Ile  Lys Gln Arg 
    2075                 2080                 2085             


Ala Ala  Lys Tyr Ala Asn Ser  Asn Pro Gln Pro Ile  Pro Gly Gln 
    2090                 2095                 2100             


Pro Gly  Met Pro Gln Gly Gln  Pro Gly Leu Gln Pro  Pro Thr Met 
    2105                 2110                 2115             


Pro Gly  Gln Gln Gly Val His  Ser Asn Pro Ala Met  Gln Asn Met 
    2120                 2125                 2130             


Asn Pro  Met Gln Ala Gly Val  Gln Arg Ala Gly Leu  Pro Gln Gln 
    2135                 2140                 2145             


Gln Pro  Gln Gln Gln Leu Gln  Pro Pro Met Gly Gly  Met Ser Pro 
    2150                 2155                 2160             


Gln Ala  Gln Gln Met Asn Met  Asn His Asn Thr Met  Pro Ser Gln 
    2165                 2170                 2175             


Phe Arg  Asp Ile Leu Arg Arg  Gln Gln Met Met Gln  Gln Gln Gln 
    2180                 2185                 2190             


Gln Gln  Gly Ala Gly Pro Gly  Ile Gly Pro Gly Met  Ala Asn His 
    2195                 2200                 2205             


Asn Gln  Phe Gln Gln Pro Gln  Gly Val Gly Tyr Pro  Pro Gln Gln 
    2210                 2215                 2220             


Gln Gln  Arg Met Gln His His  Met Gln Gln Met Gln  Gln Gly Asn 
    2225                 2230                 2235             


Met Gly  Gln Ile Gly Gln Leu  Pro Gln Ala Leu Gly  Ala Glu Ala 
    2240                 2245                 2250             


Gly Ala  Ser Leu Gln Ala Tyr  Gln Gln Arg Leu Leu  Gln Gln Gln 
    2255                 2260                 2265             


Met Gly  Ser Pro Val Gln Pro  Asn Pro Met Ser Pro  Gln Gln His 
    2270                 2275                 2280             


Met Leu  Pro Asn Gln Ala Gln  Ser Pro His Leu Gln  Gly Gln Gln 
    2285                 2290                 2295             


Ile Pro  Asn Ser Leu Ser Asn  Gln Val Arg Ser Pro  Gln Pro Val 
    2300                 2305                 2310             


Pro Ser  Pro Arg Pro Gln Ser  Gln Pro Pro His Ser  Ser Pro Ser 
    2315                 2320                 2325             


Pro Arg  Met Gln Pro Gln Pro  Ser Pro His His Val  Ser Pro Gln 
    2330                 2335                 2340             


Thr Ser  Ser Pro His Pro Gly  Leu Val Ala Ala Gln  Ala Asn Pro 
    2345                 2350                 2355             


Met Glu  Gln Gly His Phe Ala  Ser Pro Asp Gln Asn  Ser Met Leu 
    2360                 2365                 2370             


Ser Gln  Leu Ala Ser Asn Pro  Gly Met Ala Asn Leu  His Gly Ala 
    2375                 2380                 2385             


Ser Ala  Thr Asp Leu Gly Leu  Ser Thr Asp Asn Ser  Asp Leu Asn 
    2390                 2395                 2400             


Ser Asn  Leu Ser Gln Ser Thr  Leu Asp Ile His 
    2405                 2410                 


<210>  4038
<211>  3310
<212>  DNA
<213>  Homosapiens

<400>  4038
ggcaggccaa tatggcttcc tgcacctggt gacgcttggc gaaactgagg tctcatggag     60

aagccccgga gtattgagga gaccccatct tcagaaccaa tggaggaaga ggaagatgac    120

gacttggagc tgtttggtgg ctatgatagt ttccggagtt ataacagcag tgtgggcagt    180

gagagcagct cctatctgga ggagtcaagt gaagcagaaa atgaggatcg ggaagcaggg    240

gaactgccga cctccccgct gcatttgctc agccctggga ctcctcgctc cttggatggc    300

agtggttctg agccagctgt ctgtgagatg tgtggtatcg tgggtacaag ggaagccttc    360

ttctccaaga ccaagaggtt ctgcagcgtc tcctgctcca ggagctactc ctccaactcc    420

aagaaagcca gtatcttggc taggttacag ggaaaaccac cgaccaaaaa agccaaagtc    480

ctgcacaagg ctgcctggtc tgccaaaatt ggagccttcc tccactctca agggacagga    540

cagctggcag atgggacacc aacaggacaa gacgctctgg tcttgggctt cgactggggg    600

aagttcctga aggatcacag ttacaaggct gctcccgtca gctgtttcaa gcacgtccca    660

ctctatgacc agtgggagga tgtgatgaaa gggatgaagg tggaggtgct caacagtgat    720

gctgtgctcc ccagccgggt gtactggatc gcctctgtca tccagacagc agggtatcgg    780

gtgctgcttc ggtatgaagg ctttgaaaat gacgccagcc atgacttctg gtgcaacctg    840

ggaacagtgg atgtccaccc cattggctgg tgtgccatca acagcaagat cctagtgccc    900

ccacggacca tccatgccaa gttcaccgac tggaagggct acctcatgaa acggctggtg    960

ggctccagga cgcttcccgt ggatttccac atcaagatgg tggagagcat gaagtacccc   1020

tttaggcagg gcatgcggct ggaagtggtg gacaagtccc aggtgtcacg cactcgcatg   1080

gctgtggtgg acacagtaat cgggggtcgc ctacggctcc tctacgagga tggtgacagt   1140

gacgacgact tctggtgcca catgtggagc cccctgatcc acccagtggg ttggtcacga   1200

cgtgtgggcc acggcatcaa gatgtcagag aggcgaagtg acatggccca tcaccccacc   1260

ttccggaaga tctactgtga tgccgttcct tacctcttca agaaggtacg agcagtctac   1320

acagaaggcg gttggtttga ggaagggatg aagctggagg ccattgaccc cctgaatctg   1380

ggcaacatct gcgtggcaac tgtctgtaag gttctcctgg atggatacct gatgatctgt   1440

gtggacgggg ggccctccac agatggcttg gactggttct gctaccatgc ctcttcccac   1500

gccatcttcc cggccacctt ctgtcagaag aatgacattg agctcacacc gccaaaaggt   1560

tatgaggcac agactttcaa ctgggagaac tacttggaga agaccaagtc gaaagccgct   1620

ccatcgagac tctttaacat ggattgccca aaccatggct tcaaggtggg catgaagctg   1680

gaggccgtgg acctgatgga gccccggctc atctgtgtgg ccacggtgaa acgagtggtg   1740

catcggctcc tcagcatcca ctttgacggc tgggacagcg agtacgacca gtgggtggac   1800

tgcgagtccc cagacatcta ccccgtcggc tggtgtgagc tcaccggcta ccagctccag   1860

cctcctgtgg ccgcaggtaa actacccagg tccctctgag cagccctggt aacaagggtg   1920

ggaagaaggg acagctgttc tccggcccct cctccagccc cgccctctcc tcattgccca   1980

gaaccggcca caccgctgaa ggccaaagag gccacaaaga agaaaaagaa acagtttggg   2040

aagaaaagga aaagaatccc gcccactaag acgcgacccc tcagacaggg gtccaagaag   2100

cccctgctgg aggacgaccc tcagggtgcc aggaagatct cgtcggagcc tgttcctggc   2160

gagatcattg ctgtgcgtgt gaaggaagag catctagacg tggcctcgcc cgacaaggct   2220

tcaagtccag agctgcctgt ctccgtcgag aacatcaagc aggaaacaga cgactgagcc   2280

ttcctgcctc cagcctggct tctagctgga agccagccca gcgtttctct accaccacca   2340

ccatgcctcc acctgacttt ggcttggaga ctgatcctct ctgtgtaaat tctgcccggt   2400

gctgtgaagg ctggacggtg gaggacctgc tggggtctcc tgggacccgc ctgttgcttc   2460

tgccctcccc tgtggaaagg tctatatgac gggccgcctg aggccccaga actcgtctgt   2520

gaaccacctt ttccagccag agttcccaaa gctggaacgc tagctgcctg ctcttcctta   2580

agatggcctc cccccgaccc gccacggccc tcagttgcca gggatggggc caccactgtc   2640

acactgtgga atacaagaca gtgaactctg tctgcctgaa cgagccatgt aaattaagtt   2700

ctagagcagc tctctgagca ggataaggtc ccctgacagt gagttgtgtg gtgggggcag   2760

cctctgcctc aaaaattcac caagcagaat gcctctcagc ctcatgtgtt ggtcctctgc   2820

tcctcctagc tccccaggga tgttggggac ccagcttgtc tcggcagcta agaagcagtg   2880

accaggatgt ggattttggc gacctgtgtg gtggccttga gctgctttct gtgtttgtga   2940

ggactgactc ccatttccta aaggaaatgc ccccggggag gacattggga ggaagatggc   3000

ctgagtgtgc actttggctc tgctacctgc tcctgaagcc ccgctaaaaa taattcatcc   3060

aagattcctt tgtagttaaa gggtccagtt ctgactggag cctctagaga gctgggcttg   3120

tatgttcttt tggccttttg ttcctaccta aatgaagaaa ccatgcctgg aggggccgtg   3180

aacacagaac cctcaagaca aggatgacag agctggagga cacatctagc tgccattgca   3240

acctcactgg gctccccaga ctctgtgtgt gagaaattaa accccctgct tgcttgaaaa   3300

aaaaaaaaaa                                                          3310


<210>  4039
<211>  614
<212>  PRT
<213>  Homosapiens

<400>  4039

Met Glu Lys Pro Arg Ser Ile Glu Glu Thr Pro Ser Ser Glu Pro Met 
1               5                   10                  15      


Glu Glu Glu Glu Asp Asp Asp Leu Glu Leu Phe Gly Gly Tyr Asp Ser 
            20                  25                  30          


Phe Arg Ser Tyr Asn Ser Ser Val Gly Ser Glu Ser Ser Ser Tyr Leu 
        35                  40                  45              


Glu Glu Ser Ser Glu Ala Glu Asn Glu Asp Arg Glu Ala Gly Glu Leu 
    50                  55                  60                  


Pro Thr Ser Pro Leu His Leu Leu Ser Pro Gly Thr Pro Arg Ser Leu 
65                  70                  75                  80  


Asp Gly Ser Gly Ser Glu Pro Ala Val Cys Glu Met Cys Gly Ile Val 
                85                  90                  95      


Gly Thr Arg Glu Ala Phe Phe Ser Lys Thr Lys Arg Phe Cys Ser Val 
            100                 105                 110         


Ser Cys Ser Arg Ser Tyr Ser Ser Asn Ser Lys Lys Ala Ser Ile Leu 
        115                 120                 125             


Ala Arg Leu Gln Gly Lys Pro Pro Thr Lys Lys Ala Lys Val Leu His 
    130                 135                 140                 


Lys Ala Ala Trp Ser Ala Lys Ile Gly Ala Phe Leu His Ser Gln Gly 
145                 150                 155                 160 


Thr Gly Gln Leu Ala Asp Gly Thr Pro Thr Gly Gln Asp Ala Leu Val 
                165                 170                 175     


Leu Gly Phe Asp Trp Gly Lys Phe Leu Lys Asp His Ser Tyr Lys Ala 
            180                 185                 190         


Ala Pro Val Ser Cys Phe Lys His Val Pro Leu Tyr Asp Gln Trp Glu 
        195                 200                 205             


Asp Val Met Lys Gly Met Lys Val Glu Val Leu Asn Ser Asp Ala Val 
    210                 215                 220                 


Leu Pro Ser Arg Val Tyr Trp Ile Ala Ser Val Ile Gln Thr Ala Gly 
225                 230                 235                 240 


Tyr Arg Val Leu Leu Arg Tyr Glu Gly Phe Glu Asn Asp Ala Ser His 
                245                 250                 255     


Asp Phe Trp Cys Asn Leu Gly Thr Val Asp Val His Pro Ile Gly Trp 
            260                 265                 270         


Cys Ala Ile Asn Ser Lys Ile Leu Val Pro Pro Arg Thr Ile His Ala 
        275                 280                 285             


Lys Phe Thr Asp Trp Lys Gly Tyr Leu Met Lys Arg Leu Val Gly Ser 
    290                 295                 300                 


Arg Thr Leu Pro Val Asp Phe His Ile Lys Met Val Glu Ser Met Lys 
305                 310                 315                 320 


Tyr Pro Phe Arg Gln Gly Met Arg Leu Glu Val Val Asp Lys Ser Gln 
                325                 330                 335     


Val Ser Arg Thr Arg Met Ala Val Val Asp Thr Val Ile Gly Gly Arg 
            340                 345                 350         


Leu Arg Leu Leu Tyr Glu Asp Gly Asp Ser Asp Asp Asp Phe Trp Cys 
        355                 360                 365             


His Met Trp Ser Pro Leu Ile His Pro Val Gly Trp Ser Arg Arg Val 
    370                 375                 380                 


Gly His Gly Ile Lys Met Ser Glu Arg Arg Ser Asp Met Ala His His 
385                 390                 395                 400 


Pro Thr Phe Arg Lys Ile Tyr Cys Asp Ala Val Pro Tyr Leu Phe Lys 
                405                 410                 415     


Lys Val Arg Ala Val Tyr Thr Glu Gly Gly Trp Phe Glu Glu Gly Met 
            420                 425                 430         


Lys Leu Glu Ala Ile Asp Pro Leu Asn Leu Gly Asn Ile Cys Val Ala 
        435                 440                 445             


Thr Val Cys Lys Val Leu Leu Asp Gly Tyr Leu Met Ile Cys Val Asp 
    450                 455                 460                 


Gly Gly Pro Ser Thr Asp Gly Leu Asp Trp Phe Cys Tyr His Ala Ser 
465                 470                 475                 480 


Ser His Ala Ile Phe Pro Ala Thr Phe Cys Gln Lys Asn Asp Ile Glu 
                485                 490                 495     


Leu Thr Pro Pro Lys Gly Tyr Glu Ala Gln Thr Phe Asn Trp Glu Asn 
            500                 505                 510         


Tyr Leu Glu Lys Thr Lys Ser Lys Ala Ala Pro Ser Arg Leu Phe Asn 
        515                 520                 525             


Met Asp Cys Pro Asn His Gly Phe Lys Val Gly Met Lys Leu Glu Ala 
    530                 535                 540                 


Val Asp Leu Met Glu Pro Arg Leu Ile Cys Val Ala Thr Val Lys Arg 
545                 550                 555                 560 


Val Val His Arg Leu Leu Ser Ile His Phe Asp Gly Trp Asp Ser Glu 
                565                 570                 575     


Tyr Asp Gln Trp Val Asp Cys Glu Ser Pro Asp Ile Tyr Pro Val Gly 
            580                 585                 590         


Trp Cys Glu Leu Thr Gly Tyr Gln Leu Gln Pro Pro Val Ala Ala Gly 
        595                 600                 605             


Lys Leu Pro Arg Ser Leu 
    610                 


<210>  4040
<211>  3205
<212>  DNA
<213>  Homosapiens

<400>  4040
ggcaggccaa tatggcttcc tgcacctggt gacgcttggc gaaactgagg tctcatggag     60

aagccccgga gtattgagga gaccccatct tcagaaccaa tggaggaaga ggaagatgac    120

gacttggagc tgtttggtgg ctatgatagt ttccggagtt ataacagcag tgtgggcagt    180

gagagcagct cctatctgga ggagtcaagt gaagcagaaa atgaggatcg ggaagcaggg    240

gaactgccga cctccccgct gcatttgctc agccctggga ctcctcgctc cttggatggc    300

agtggttctg agccagctgt ctgtgagatg tgtggtatcg tgggtacaag ggaagccttc    360

ttctccaaga ccaagaggtt ctgcagcgtc tcctgctcca ggagctactc ctccaactcc    420

aagaaagcca gtatcttggc taggttacag ggaaaaccac cgaccaaaaa agccaaagtc    480

ctgcacaagg ctgcctggtc tgccaaaatt ggagccttcc tccactctca agggacagga    540

cagctggcag atgggacacc aacaggacaa gacgctctgg tcttgggctt cgactggggg    600

aagttcctga aggatcacag ttacaaggct gctcccgtca gctgtttcaa gcacgtccca    660

ctctatgacc agtgggagga tgtgatgaaa gggatgaagg tggaggtgct caacagtgat    720

gctgtgctcc ccagccgggt gtactggatc gcctctgtca tccagacagc agggtatcgg    780

gtgctgcttc ggtatgaagg ctttgaaaat gacgccagcc atgacttctg gtgcaacctg    840

ggaacagtgg atgtccaccc cattggctgg tgtgccatca acagcaagat cctagtgccc    900

ccacggacca tccatgccaa gttcaccgac tggaagggct acctcatgaa acggctggtg    960

ggctccagga cgcttcccgt ggatttccac atcaagatgg tggagagcat gaagtacccc   1020

tttaggcagg gcatgcggct ggaagtggtg gacaagtccc aggtgtcacg cactcgcatg   1080

gctgtggtgg acacagtaat cgggggtcgc ctacggctcc tctacgagga tggtgacagt   1140

gacgacgact tctggtgcca catgtggagc cccctgatcc acccagtggg ttggtcacga   1200

cgtgtgggcc acggcatcaa gatgtcagag aggcgaagtg acatggccca tcaccccacc   1260

ttccggaaga tctactgtga tgccgttcct tacctcttca agaaggtacg agcagtctac   1320

acagaaggcg gttggtttga ggaagggatg aagctggagg ccattgaccc cctgaatctg   1380

ggcaacatct gcgtggcaac tgtctgtaag gttctcctgg atggatacct gatgatctgt   1440

gtggacgggg ggccctccac agatggcttg gactggttct gctaccatgc ctcttcccac   1500

gccatcttcc cggccacctt ctgtcagaag aatgacattg agctcacacc gccaaaaggt   1560

tatgaggcac agactttcaa ctgggagaac tacttggaga agaccaagtc gaaagccgct   1620

ccatcgagac tctttaacat ggattgccca aaccatggct tcaaggtggg catgaagctg   1680

gaggccgtgg acctgatgga gccccggctc atctgtgtgg ccacggtgaa acgagtggtg   1740

catcggctcc tcagcatcca ctttgacggc tgggacagcg agtacgacca gtgggtggac   1800

tgcgagtccc cagacatcta ccccgtcggc tggtgtgagc tcaccggcta ccagctccag   1860

cctcctgtgg ccgcagaacc ggccacaccg ctgaaggcca aagaggccac aaagaagaaa   1920

aagaaacagt ttgggaagaa aaggaaaaga atcccgccca ctaagacgcg acccctcaga   1980

caggggtcca agaagcccct gctggaggac gaccctcagg gtgccaggaa gatctcgtcg   2040

gagcctgttc ctggcgagat cattgctgtg cgtgtgaagg aagagcatct agacgtggcc   2100

tcgcccgaca aggcttcaag tccagagctg cctgtctccg tcgagaacat caagcaggaa   2160

acagacgact gagccttcct gcctccagcc tggcttctag ctggaagcca gcccagcgtt   2220

tctctaccac caccaccatg cctccacctg actttggctt ggagactgat cctctctgtg   2280

taaattctgc ccggtgctgt gaaggctgga cggtggagga cctgctgggg tctcctggga   2340

cccgcctgtt gcttctgccc tcccctgtgg aaaggtctat atgacgggcc gcctgaggcc   2400

ccagaactcg tctgtgaacc accttttcca gccagagttc ccaaagctgg aacgctagct   2460

gcctgctctt ccttaagatg gcctcccccc gacccgccac ggccctcagt tgccagggat   2520

ggggccacca ctgtcacact gtggaataca agacagtgaa ctctgtctgc ctgaacgagc   2580

catgtaaatt aagttctaga gcagctctct gagcaggata aggtcccctg acagtgagtt   2640

gtgtggtggg ggcagcctct gcctcaaaaa ttcaccaagc agaatgcctc tcagcctcat   2700

gtgttggtcc tctgctcctc ctagctcccc agggatgttg gggacccagc ttgtctcggc   2760

agctaagaag cagtgaccag gatgtggatt ttggcgacct gtgtggtggc cttgagctgc   2820

tttctgtgtt tgtgaggact gactcccatt tcctaaagga aatgcccccg gggaggacat   2880

tgggaggaag atggcctgag tgtgcacttt ggctctgcta cctgctcctg aagccccgct   2940

aaaaataatt catccaagat tcctttgtag ttaaagggtc cagttctgac tggagcctct   3000

agagagctgg gcttgtatgt tcttttggcc ttttgttcct acctaaatga agaaaccatg   3060

cctggagggg ccgtgaacac agaaccctca agacaaggat gacagagctg gaggacacat   3120

ctagctgcca ttgcaacctc actgggctcc ccagactctg tgtgtgagaa attaaacccc   3180

ctgcttgctt gaaaaaaaaa aaaaa                                         3205


<210>  4041
<211>  705
<212>  PRT
<213>  Homosapiens

<400>  4041

Met Glu Lys Pro Arg Ser Ile Glu Glu Thr Pro Ser Ser Glu Pro Met 
1               5                   10                  15      


Glu Glu Glu Glu Asp Asp Asp Leu Glu Leu Phe Gly Gly Tyr Asp Ser 
            20                  25                  30          


Phe Arg Ser Tyr Asn Ser Ser Val Gly Ser Glu Ser Ser Ser Tyr Leu 
        35                  40                  45              


Glu Glu Ser Ser Glu Ala Glu Asn Glu Asp Arg Glu Ala Gly Glu Leu 
    50                  55                  60                  


Pro Thr Ser Pro Leu His Leu Leu Ser Pro Gly Thr Pro Arg Ser Leu 
65                  70                  75                  80  


Asp Gly Ser Gly Ser Glu Pro Ala Val Cys Glu Met Cys Gly Ile Val 
                85                  90                  95      


Gly Thr Arg Glu Ala Phe Phe Ser Lys Thr Lys Arg Phe Cys Ser Val 
            100                 105                 110         


Ser Cys Ser Arg Ser Tyr Ser Ser Asn Ser Lys Lys Ala Ser Ile Leu 
        115                 120                 125             


Ala Arg Leu Gln Gly Lys Pro Pro Thr Lys Lys Ala Lys Val Leu His 
    130                 135                 140                 


Lys Ala Ala Trp Ser Ala Lys Ile Gly Ala Phe Leu His Ser Gln Gly 
145                 150                 155                 160 


Thr Gly Gln Leu Ala Asp Gly Thr Pro Thr Gly Gln Asp Ala Leu Val 
                165                 170                 175     


Leu Gly Phe Asp Trp Gly Lys Phe Leu Lys Asp His Ser Tyr Lys Ala 
            180                 185                 190         


Ala Pro Val Ser Cys Phe Lys His Val Pro Leu Tyr Asp Gln Trp Glu 
        195                 200                 205             


Asp Val Met Lys Gly Met Lys Val Glu Val Leu Asn Ser Asp Ala Val 
    210                 215                 220                 


Leu Pro Ser Arg Val Tyr Trp Ile Ala Ser Val Ile Gln Thr Ala Gly 
225                 230                 235                 240 


Tyr Arg Val Leu Leu Arg Tyr Glu Gly Phe Glu Asn Asp Ala Ser His 
                245                 250                 255     


Asp Phe Trp Cys Asn Leu Gly Thr Val Asp Val His Pro Ile Gly Trp 
            260                 265                 270         


Cys Ala Ile Asn Ser Lys Ile Leu Val Pro Pro Arg Thr Ile His Ala 
        275                 280                 285             


Lys Phe Thr Asp Trp Lys Gly Tyr Leu Met Lys Arg Leu Val Gly Ser 
    290                 295                 300                 


Arg Thr Leu Pro Val Asp Phe His Ile Lys Met Val Glu Ser Met Lys 
305                 310                 315                 320 


Tyr Pro Phe Arg Gln Gly Met Arg Leu Glu Val Val Asp Lys Ser Gln 
                325                 330                 335     


Val Ser Arg Thr Arg Met Ala Val Val Asp Thr Val Ile Gly Gly Arg 
            340                 345                 350         


Leu Arg Leu Leu Tyr Glu Asp Gly Asp Ser Asp Asp Asp Phe Trp Cys 
        355                 360                 365             


His Met Trp Ser Pro Leu Ile His Pro Val Gly Trp Ser Arg Arg Val 
    370                 375                 380                 


Gly His Gly Ile Lys Met Ser Glu Arg Arg Ser Asp Met Ala His His 
385                 390                 395                 400 


Pro Thr Phe Arg Lys Ile Tyr Cys Asp Ala Val Pro Tyr Leu Phe Lys 
                405                 410                 415     


Lys Val Arg Ala Val Tyr Thr Glu Gly Gly Trp Phe Glu Glu Gly Met 
            420                 425                 430         


Lys Leu Glu Ala Ile Asp Pro Leu Asn Leu Gly Asn Ile Cys Val Ala 
        435                 440                 445             


Thr Val Cys Lys Val Leu Leu Asp Gly Tyr Leu Met Ile Cys Val Asp 
    450                 455                 460                 


Gly Gly Pro Ser Thr Asp Gly Leu Asp Trp Phe Cys Tyr His Ala Ser 
465                 470                 475                 480 


Ser His Ala Ile Phe Pro Ala Thr Phe Cys Gln Lys Asn Asp Ile Glu 
                485                 490                 495     


Leu Thr Pro Pro Lys Gly Tyr Glu Ala Gln Thr Phe Asn Trp Glu Asn 
            500                 505                 510         


Tyr Leu Glu Lys Thr Lys Ser Lys Ala Ala Pro Ser Arg Leu Phe Asn 
        515                 520                 525             


Met Asp Cys Pro Asn His Gly Phe Lys Val Gly Met Lys Leu Glu Ala 
    530                 535                 540                 


Val Asp Leu Met Glu Pro Arg Leu Ile Cys Val Ala Thr Val Lys Arg 
545                 550                 555                 560 


Val Val His Arg Leu Leu Ser Ile His Phe Asp Gly Trp Asp Ser Glu 
                565                 570                 575     


Tyr Asp Gln Trp Val Asp Cys Glu Ser Pro Asp Ile Tyr Pro Val Gly 
            580                 585                 590         


Trp Cys Glu Leu Thr Gly Tyr Gln Leu Gln Pro Pro Val Ala Ala Glu 
        595                 600                 605             


Pro Ala Thr Pro Leu Lys Ala Lys Glu Ala Thr Lys Lys Lys Lys Lys 
    610                 615                 620                 


Gln Phe Gly Lys Lys Arg Lys Arg Ile Pro Pro Thr Lys Thr Arg Pro 
625                 630                 635                 640 


Leu Arg Gln Gly Ser Lys Lys Pro Leu Leu Glu Asp Asp Pro Gln Gly 
                645                 650                 655     


Ala Arg Lys Ile Ser Ser Glu Pro Val Pro Gly Glu Ile Ile Ala Val 
            660                 665                 670         


Arg Val Lys Glu Glu His Leu Asp Val Ala Ser Pro Asp Lys Ala Ser 
        675                 680                 685             


Ser Pro Glu Leu Pro Val Ser Val Glu Asn Ile Lys Gln Glu Thr Asp 
    690                 695                 700                 


Asp 
705 


<210>  4042
<211>  2310
<212>  DNA
<213>  Homosapiens

<400>  4042
atggtgcaag gggggattca gagcagctca gtggcctcag gctctggaga agccaccaac     60

tccaacgcag gggctggagc ctgggaccca aaggagactc caaaacagac gatagtccag    120

ccccggagct ccacccatgt ccccttggtg ctgccgcttc ttgtacttct gctgctggcc    180

ccggctaggc aggccgccgc ccagcgctgc ccacaggcct gcatctgtga caactccagg    240

cgacacgttg cctgccggta ccagaacctc actgaggtgc cagacgccat ccctgagctg    300

acccagcggc tggacctgca gggcaatttg ctgaaggtga tccccgcagc cgccttccag    360

ggcgtgcctc acctcacaca cctggacctg cgccactgcg aggtggagct ggtggccgag    420

ggcgccttcc gtggcctggg ccgcctgctc ctgctcaacc tggcctccaa ccacctgcgt    480

gagctgcccc aggaggcgct ggacgggctg ggctcgttgc ggcggctgga gctggagggg    540

aacgcactgg aggagctgcg gccggggacg ttcggggcac tgggtgcgct ggccacgcta    600

aacctggccc acaacgccct ggtttacctg cccgccatgg ccttccaggg gctactgcgc    660

gtccgctggc tgcggctgtc gcacaacgcg ctcagcgtgc tggcccccga ggccctggct    720

ggcctgcccg ccctgagacg gctcagccta caccacaacg agctccaggc tctgcccggg    780

cctgtcttgt cccaggcccg cggcctggcc cgtctggagc tgggccacaa cccgctcacc    840

tacgcgggcg aggaggacgg gctggcgctg cccggcctgc gggagctgct gctggacggc    900

ggggccctgc aggccctggg tcccagggcc ttcgcacact gtccgcgcct gcacaccctc    960

gacctccgcg ggaaccagct agacaccctg cccccgctgc agggcccggg ccagctgcgc   1020

cggctgcggc tgcaggggaa tccgctgtgg tgcggctgcc aggcgcggcc cctactcgag   1080

tggctggcgc gggcgcgcga agaggaagag ctggaagagc gggctgtggc cgggccccgc   1140

gcccctccgc gcggccctcc gcgcggcccc ggggaggagc gggcagtcgc gccttgccct   1200

cgcgcctgcg tgtgcgtccc cgagtcccgg cacagcagct gcgagggctg cggcctgcag   1260

gcggtgcccc gcggcttccc cagcgacacc cagctcctgg acctgaggcg gaaccacttc   1320

ccctcggtgc cccgagcggc cttccccggc ctgggccacc tggtgtcgct gcacctgcag   1380

cactgcggca tcgcggagct ggaagcgggc gccctggccg ggctgggccg cctgatctac   1440

ctgtacctct ccgacaacca gctcgcaggc ctcagcgctg ctgcccttga aggggctccc   1500

cgcctcggct acctgtacct agaacgcaac cgtttcctgc aggtgccagg ggctgccctg   1560

cgcgccctgc ccagcctctt ctccctgcac ctgcaggaca acgctgtgga ccgcctggca   1620

cctggggacc tggggagaac acgggccttg cgctgggtct acctgagtgg aaaccgcatc   1680

accgaagtgt cccttggggc gctgggccca gctcgggagc tggagaagct gcacctggac   1740

aggaatcagc tgcgagaggt gcccactggg gccttggagg ggctgcctgc cctcctggag   1800

ctgcagctct cgggcaaccc actcagggcc ttgcgtgacg gagccttcca gcctgtgggc   1860

aggtcgctgc agcacctctt cctgaacagc agtggcctgg agcagatttg tcctggggcc   1920

ttttcaggcc tggggcccgg gctccagagc ctgcacctgc agaagaacca gcttcgggcc   1980

ctgcctgccc tgcccagtct cagccagctg gagctcatcg acctcagcag caatcccttc   2040

cactgtgact gccagctgct tccgctgcac aggtggctta ctgggctgaa cctgcgggtg   2100

ggggccacct gcgccacccc tcccaatgcc cgtggccaga gggtgaaggc tgcagctgct   2160

gtctttgaag actgcccggg ctgggctgcc agaaaggcca agcggacacc agcctccagg   2220

cccagtgcca ggagaacccc catcaaagga agacagtgct ccctgatctg tggcagcata   2280

atctccatct ctgtcccaac cttcacgtga                                    2310


<210>  4043
<211>  769
<212>  PRT
<213>  Homosapiens

<400>  4043

Met Val Gln Gly Gly Ile Gln Ser Ser Ser Val Ala Ser Gly Ser Gly 
1               5                   10                  15      


Glu Ala Thr Asn Ser Asn Ala Gly Ala Gly Ala Trp Asp Pro Lys Glu 
            20                  25                  30          


Thr Pro Lys Gln Thr Ile Val Gln Pro Arg Ser Ser Thr His Val Pro 
        35                  40                  45              


Leu Val Leu Pro Leu Leu Val Leu Leu Leu Leu Ala Pro Ala Arg Gln 
    50                  55                  60                  


Ala Ala Ala Gln Arg Cys Pro Gln Ala Cys Ile Cys Asp Asn Ser Arg 
65                  70                  75                  80  


Arg His Val Ala Cys Arg Tyr Gln Asn Leu Thr Glu Val Pro Asp Ala 
                85                  90                  95      


Ile Pro Glu Leu Thr Gln Arg Leu Asp Leu Gln Gly Asn Leu Leu Lys 
            100                 105                 110         


Val Ile Pro Ala Ala Ala Phe Gln Gly Val Pro His Leu Thr His Leu 
        115                 120                 125             


Asp Leu Arg His Cys Glu Val Glu Leu Val Ala Glu Gly Ala Phe Arg 
    130                 135                 140                 


Gly Leu Gly Arg Leu Leu Leu Leu Asn Leu Ala Ser Asn His Leu Arg 
145                 150                 155                 160 


Glu Leu Pro Gln Glu Ala Leu Asp Gly Leu Gly Ser Leu Arg Arg Leu 
                165                 170                 175     


Glu Leu Glu Gly Asn Ala Leu Glu Glu Leu Arg Pro Gly Thr Phe Gly 
            180                 185                 190         


Ala Leu Gly Ala Leu Ala Thr Leu Asn Leu Ala His Asn Ala Leu Val 
        195                 200                 205             


Tyr Leu Pro Ala Met Ala Phe Gln Gly Leu Leu Arg Val Arg Trp Leu 
    210                 215                 220                 


Arg Leu Ser His Asn Ala Leu Ser Val Leu Ala Pro Glu Ala Leu Ala 
225                 230                 235                 240 


Gly Leu Pro Ala Leu Arg Arg Leu Ser Leu His His Asn Glu Leu Gln 
                245                 250                 255     


Ala Leu Pro Gly Pro Val Leu Ser Gln Ala Arg Gly Leu Ala Arg Leu 
            260                 265                 270         


Glu Leu Gly His Asn Pro Leu Thr Tyr Ala Gly Glu Glu Asp Gly Leu 
        275                 280                 285             


Ala Leu Pro Gly Leu Arg Glu Leu Leu Leu Asp Gly Gly Ala Leu Gln 
    290                 295                 300                 


Ala Leu Gly Pro Arg Ala Phe Ala His Cys Pro Arg Leu His Thr Leu 
305                 310                 315                 320 


Asp Leu Arg Gly Asn Gln Leu Asp Thr Leu Pro Pro Leu Gln Gly Pro 
                325                 330                 335     


Gly Gln Leu Arg Arg Leu Arg Leu Gln Gly Asn Pro Leu Trp Cys Gly 
            340                 345                 350         


Cys Gln Ala Arg Pro Leu Leu Glu Trp Leu Ala Arg Ala Arg Glu Glu 
        355                 360                 365             


Glu Glu Leu Glu Glu Arg Ala Val Ala Gly Pro Arg Ala Pro Pro Arg 
    370                 375                 380                 


Gly Pro Pro Arg Gly Pro Gly Glu Glu Arg Ala Val Ala Pro Cys Pro 
385                 390                 395                 400 


Arg Ala Cys Val Cys Val Pro Glu Ser Arg His Ser Ser Cys Glu Gly 
                405                 410                 415     


Cys Gly Leu Gln Ala Val Pro Arg Gly Phe Pro Ser Asp Thr Gln Leu 
            420                 425                 430         


Leu Asp Leu Arg Arg Asn His Phe Pro Ser Val Pro Arg Ala Ala Phe 
        435                 440                 445             


Pro Gly Leu Gly His Leu Val Ser Leu His Leu Gln His Cys Gly Ile 
    450                 455                 460                 


Ala Glu Leu Glu Ala Gly Ala Leu Ala Gly Leu Gly Arg Leu Ile Tyr 
465                 470                 475                 480 


Leu Tyr Leu Ser Asp Asn Gln Leu Ala Gly Leu Ser Ala Ala Ala Leu 
                485                 490                 495     


Glu Gly Ala Pro Arg Leu Gly Tyr Leu Tyr Leu Glu Arg Asn Arg Phe 
            500                 505                 510         


Leu Gln Val Pro Gly Ala Ala Leu Arg Ala Leu Pro Ser Leu Phe Ser 
        515                 520                 525             


Leu His Leu Gln Asp Asn Ala Val Asp Arg Leu Ala Pro Gly Asp Leu 
    530                 535                 540                 


Gly Arg Thr Arg Ala Leu Arg Trp Val Tyr Leu Ser Gly Asn Arg Ile 
545                 550                 555                 560 


Thr Glu Val Ser Leu Gly Ala Leu Gly Pro Ala Arg Glu Leu Glu Lys 
                565                 570                 575     


Leu His Leu Asp Arg Asn Gln Leu Arg Glu Val Pro Thr Gly Ala Leu 
            580                 585                 590         


Glu Gly Leu Pro Ala Leu Leu Glu Leu Gln Leu Ser Gly Asn Pro Leu 
        595                 600                 605             


Arg Ala Leu Arg Asp Gly Ala Phe Gln Pro Val Gly Arg Ser Leu Gln 
    610                 615                 620                 


His Leu Phe Leu Asn Ser Ser Gly Leu Glu Gln Ile Cys Pro Gly Ala 
625                 630                 635                 640 


Phe Ser Gly Leu Gly Pro Gly Leu Gln Ser Leu His Leu Gln Lys Asn 
                645                 650                 655     


Gln Leu Arg Ala Leu Pro Ala Leu Pro Ser Leu Ser Gln Leu Glu Leu 
            660                 665                 670         


Ile Asp Leu Ser Ser Asn Pro Phe His Cys Asp Cys Gln Leu Leu Pro 
        675                 680                 685             


Leu His Arg Trp Leu Thr Gly Leu Asn Leu Arg Val Gly Ala Thr Cys 
    690                 695                 700                 


Ala Thr Pro Pro Asn Ala Arg Gly Gln Arg Val Lys Ala Ala Ala Ala 
705                 710                 715                 720 


Val Phe Glu Asp Cys Pro Gly Trp Ala Ala Arg Lys Ala Lys Arg Thr 
                725                 730                 735     


Pro Ala Ser Arg Pro Ser Ala Arg Arg Thr Pro Ile Lys Gly Arg Gln 
            740                 745                 750         


Cys Ser Leu Ile Cys Gly Ser Ile Ile Ser Ile Ser Val Pro Thr Phe 
        755                 760                 765             


Thr 
    


<210>  4044
<211>  3040
<212>  DNA
<213>  Homosapiens

<400>  4044
aaatcctcct cctccgccat catccgccgc ggtgcggaga gcaggtggtg ctggaagcgc     60

gtgaggccgg gagctcgaga gagctaacag actagccggc tggacatctg gaccgctgga    120

tccggaggtg gcgaccccgg cctgacccgg accctaaatc cgtccccgcc ccagagggcg    180

gaggcgcgcg ctcgattccc cccacgcggc ggcgccgcct gtttacgtct gcagatctcc    240

aggggagccc accagcctag tcaacatggc ctcggaagac attgccaagc tggcagagac    300

acttgccaag actcaggtgg ccgggggaca gctgagtttc aaaggcaaga gcctcaaact    360

caacactgca gaagatgcta aagatgtgat taaagagatt gaagactttg acagcttgga    420

ggctctgcgt ctggaaggca acacagtggg cgtggaagca gccagggtca tcgccaaggc    480

cttagagaag aagtcggagt tgaagcgctg ccactggagt gacatgttca cgggaaggct    540

gcggaccgag atcccaccag ccctgatctc actaggggaa ggactcatca cagctggggc    600

tcagctggtg gagctggact taagcgacaa cgcattcggg cccgacggtg tgcaaggctt    660

cgaggccctg ctcaagagct cagcctgctt caccctgcag gaactcaagc tcaacaactg    720

tggcatgggc attggcggcg gcaagatcct ggctgcagct ctgaccgaat gtcaccggaa    780

atccagtgcc caaggcaagc ctctggccct gaaggtcttt gtggctggca gaaaccgtct    840

ggagaatgat ggcgccactg ccttggcaga agcttttagg gtcatcggga ccctggagga    900

ggtccacatg ccacagaatg ggatcaacca ccctggcatc actgccctgg cccaggcttt    960

cgctgtcaac cccctgctgc gggtcatcaa cctgaatgac aacaccttca ctgagaaggg   1020

cgccgtggcc atggccgaga ccttgaagac cttgcggcag gtggaggtga ttaattttgg   1080

ggactgcctg gtgcgctcca agggtgcagt tgccattgca gatgccatcc gcggcggcct   1140

gcccaagcta aaggagctga acttgtcatt ctgtgaaatc aagagggatg ctgccctggc   1200

tgttgctgag gccatggcag acaaagctga gctggagaag ctggacctga atggcaacac   1260

cctgggagaa gaaggctgtg aacagcttca ggaggtgctg gagggcttca acatggccaa   1320

ggtgctggcg tccctcagtg atgacgagga cgaggaggag gaggaggaag gagaagagga   1380

agaagaggaa gcagaagaag aggaggagga agatgaggaa gaggaggaag aagaggagga   1440

ggaggaggaa gaagagcctc agcagcgagg gcagggagag aagtcagcca cgccctcacg   1500

gaagattctg gaccctaaca ctggggagcc agctcccgtg ctgtcctccc cacctcctgc   1560

agacgtctcc accttcctgg cttttccctc tccagagaag ctgctgcgcc tagggcccaa   1620

gagctccgtg ctgatagccc agcagactga cacgtctgac cccgagaagg tggtctctgc   1680

cttcctaaag gtgtcatctg tgttcaagga cgaagctact gtgaggatgg cagtgcagga   1740

tgcagtagat gccctgatgc agaaggcttt caactcctcg tccttcaact ccaacacctt   1800

cctcaccagg ctgctcgtgc acatgggtct gctcaagagt gaagacaagg tcaaggccat   1860

tgccaacctg tacggccccc tgatggcgct gaaccacatg gtgcagcagg actatttccc   1920

caaggccctt gcacccctgc tgctggcgtt cgtgaccaag cccaacagcg ccctggaatc   1980

ctgctccttc gcccgccaca gtctgctgca gacgctgtac aaggtctaga ctcaaagcct   2040

ctcccatccc ttggcctgga ccagtgagct ggggagggac tcggatgaac tgaggcgcag   2100

cctacgccat tgccttggac aggactctgg ccacaggcag ggcgggtctg tgtcccatgt   2160

gtcctgtcag tcccctgagt atgtgtgtgg gtgtggcgca tgtgcaggtc tgtgcctcct   2220

gtcgggattt gggttttaac gtcttctgct ggcccagccc tgctctgttg tggggagttg   2280

gcccccaggg gaaagggctg tgagctgctc cgccattaaa ctcacctcca cctgagggcg   2340

ctctgctgat ctccgcctgg gccctgatgg ccgtccccac ccacctgcct tccggcccgg   2400

ctccctggcg gagccagaac ccagggagtt gcccgcgtgc tgtccttccc ctctgtgttg   2460

tgattgggtt gtttcctgcc ctgcctgggg ctgcttctcg tcaccaagcc ctggtcctgc   2520

ggcagctgtc acccctacca tccataccac tgtgctgacc gctcagcctg aagagcagag   2580

aatgccatgg gtgggactgt gggggtcgga tcgtggggtt gttggcagag ggcaaccctg   2640

ggccccacac cgtgtggaca ggcagacacc agattgtcca ggagcaggag ctgctgggac   2700

tgcgctggcc ccggacctag tgggccttct cctggctgct gagatgtcgt ctgtgactgg   2760

cctggctgga gggggagtgt tgacaaccca aagctgttct ccagtctggg gagggagagg   2820

cagggtcccc aatgtccgag ctgcatctgg acgctgctct taaaggacct cctggggcag   2880

gggagcggta gggtctggac tgggcagatg ctgtatgacc tccctgagca cccgtgactg   2940

ccccatgctt tcccctttgt gctctgtgtg tgtctgggct gtgcccgggg gcttcacaaa   3000

taaagtcgtg tggcagcttc aaaaaaaaaa aaaaaaaaaa                         3040


<210>  4045
<211>  587
<212>  PRT
<213>  Homosapiens

<400>  4045

Met Ala Ser Glu Asp Ile Ala Lys Leu Ala Glu Thr Leu Ala Lys Thr 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Leu Ser Phe Lys Gly Lys Ser Leu Lys Leu 
            20                  25                  30          


Asn Thr Ala Glu Asp Ala Lys Asp Val Ile Lys Glu Ile Glu Asp Phe 
        35                  40                  45              


Asp Ser Leu Glu Ala Leu Arg Leu Glu Gly Asn Thr Val Gly Val Glu 
    50                  55                  60                  


Ala Ala Arg Val Ile Ala Lys Ala Leu Glu Lys Lys Ser Glu Leu Lys 
65                  70                  75                  80  


Arg Cys His Trp Ser Asp Met Phe Thr Gly Arg Leu Arg Thr Glu Ile 
                85                  90                  95      


Pro Pro Ala Leu Ile Ser Leu Gly Glu Gly Leu Ile Thr Ala Gly Ala 
            100                 105                 110         


Gln Leu Val Glu Leu Asp Leu Ser Asp Asn Ala Phe Gly Pro Asp Gly 
        115                 120                 125             


Val Gln Gly Phe Glu Ala Leu Leu Lys Ser Ser Ala Cys Phe Thr Leu 
    130                 135                 140                 


Gln Glu Leu Lys Leu Asn Asn Cys Gly Met Gly Ile Gly Gly Gly Lys 
145                 150                 155                 160 


Ile Leu Ala Ala Ala Leu Thr Glu Cys His Arg Lys Ser Ser Ala Gln 
                165                 170                 175     


Gly Lys Pro Leu Ala Leu Lys Val Phe Val Ala Gly Arg Asn Arg Leu 
            180                 185                 190         


Glu Asn Asp Gly Ala Thr Ala Leu Ala Glu Ala Phe Arg Val Ile Gly 
        195                 200                 205             


Thr Leu Glu Glu Val His Met Pro Gln Asn Gly Ile Asn His Pro Gly 
    210                 215                 220                 


Ile Thr Ala Leu Ala Gln Ala Phe Ala Val Asn Pro Leu Leu Arg Val 
225                 230                 235                 240 


Ile Asn Leu Asn Asp Asn Thr Phe Thr Glu Lys Gly Ala Val Ala Met 
                245                 250                 255     


Ala Glu Thr Leu Lys Thr Leu Arg Gln Val Glu Val Ile Asn Phe Gly 
            260                 265                 270         


Asp Cys Leu Val Arg Ser Lys Gly Ala Val Ala Ile Ala Asp Ala Ile 
        275                 280                 285             


Arg Gly Gly Leu Pro Lys Leu Lys Glu Leu Asn Leu Ser Phe Cys Glu 
    290                 295                 300                 


Ile Lys Arg Asp Ala Ala Leu Ala Val Ala Glu Ala Met Ala Asp Lys 
305                 310                 315                 320 


Ala Glu Leu Glu Lys Leu Asp Leu Asn Gly Asn Thr Leu Gly Glu Glu 
                325                 330                 335     


Gly Cys Glu Gln Leu Gln Glu Val Leu Glu Gly Phe Asn Met Ala Lys 
            340                 345                 350         


Val Leu Ala Ser Leu Ser Asp Asp Glu Asp Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Gly Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Asp Glu 
    370                 375                 380                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro Gln Gln 
385                 390                 395                 400 


Arg Gly Gln Gly Glu Lys Ser Ala Thr Pro Ser Arg Lys Ile Leu Asp 
                405                 410                 415     


Pro Asn Thr Gly Glu Pro Ala Pro Val Leu Ser Ser Pro Pro Pro Ala 
            420                 425                 430         


Asp Val Ser Thr Phe Leu Ala Phe Pro Ser Pro Glu Lys Leu Leu Arg 
        435                 440                 445             


Leu Gly Pro Lys Ser Ser Val Leu Ile Ala Gln Gln Thr Asp Thr Ser 
    450                 455                 460                 


Asp Pro Glu Lys Val Val Ser Ala Phe Leu Lys Val Ser Ser Val Phe 
465                 470                 475                 480 


Lys Asp Glu Ala Thr Val Arg Met Ala Val Gln Asp Ala Val Asp Ala 
                485                 490                 495     


Leu Met Gln Lys Ala Phe Asn Ser Ser Ser Phe Asn Ser Asn Thr Phe 
            500                 505                 510         


Leu Thr Arg Leu Leu Val His Met Gly Leu Leu Lys Ser Glu Asp Lys 
        515                 520                 525             


Val Lys Ala Ile Ala Asn Leu Tyr Gly Pro Leu Met Ala Leu Asn His 
    530                 535                 540                 


Met Val Gln Gln Asp Tyr Phe Pro Lys Ala Leu Ala Pro Leu Leu Leu 
545                 550                 555                 560 


Ala Phe Val Thr Lys Pro Asn Ser Ala Leu Glu Ser Cys Ser Phe Ala 
                565                 570                 575     


Arg His Ser Leu Leu Gln Thr Leu Tyr Lys Val 
            580                 585         


<210>  4046
<211>  5868
<212>  DNA
<213>  Homosapiens

<400>  4046
gccgaggggc tggaaatgaa agtaaagcgc tccagagcca catggacgga gctgccgggg     60

cggcggcgcc gggagcagga tgcggccgcc cgtaattaaa tagcatttac tcttattatt    120

actaataata ataacgtaat catacctcta gtcatagcat accatttatc gggctcggcg    180

caggcccgcg gggagcgcag cccggcggag agactgatgg agaggcagaa acggaaggcg    240

gacatcgaga aagggctgca gttcattcag tcgacactac ccctaaagca agaagaatat    300

gaggcctttc tgctcaagct ggtgcagaat ctgtttgctg agggcaatga tctgttccgg    360

gagaaggact ataagcaggc tctggtgcag tacatggaag ggctgaacgt ggccgactac    420

gctgcctctg accaggtggc cctgccccgg gagctgctgt gcaagctgca tgtcaatagg    480

gccgcctgct acttcaccat gggcctgtat gagaaggcgc tggaggacag cgagaaggcg    540

ctgggcctgg acagtgagag tatccgggcg ttgttccgca aggcacgcgc tctcaatgaa    600

ctgggacgcc acaaggaggc ctacgagtgc agcagccggt gttccctcgc cctgccccac    660

gatgaaagcg tgactcagct tggtcaggag ctggcccaga aactggggct gcgagttcgc    720

aaggcgtata agaggcccca ggaattggaa accttttctc tgctcagtaa cggcactgcg    780

gctggcgtgg cagatcaggg aacttctaat ggattggggt ccatagatga catcgaaaca    840

gactgctacg tggaccctcg aggctcccca gcccttctcc cctccacgcc cacgatgccc    900

ctgttccctc acgttctgga cctgctggcc cccctggaca gcagcaggac cctccccagc    960

accgacagcc tggatgactt ctcagacggg gatgtctttg gcccagagct ggacaccctc   1020

ctggactcgc tgtctctggt ccagggtggc ctgtctggca gcggcgtgcc tagtgagttg   1080

ccccagctga tacccgtgtt ccccggcggg accccactgc taccacctgt ggtgggtggc   1140

tccatccctg tctccagccc actgcccccc gcctccttcg gcttggtcat ggacccctcc   1200

aagaagctgg ccgcctctgt gctggatgcc ctcgatcccc cgggccccac gctggacccc   1260

ctggacctgc tgccgtactc ggagacccgg ctggatgcac tcgacagctt tgggtcgaca   1320

cgaggctccc tggacaaacc tgactccttc atggaggaga ccaactcaca ggaccaccgt   1380

ccccctagcg gtgctcagaa accagccccc tcgccagagc cctgcatgcc caacactgcc   1440

ttgctcatca agaacccctt ggctgccacc cacgagttca agcaggcctg ccagctctgc   1500

taccccaaga caggcccccg ggctggcgac tacacctacc gtgagggcct tgagcacaag   1560

tgcaagcggg acatcctgct cggccggctc cggagctcgg aggaccagac ctggaagcgg   1620

atccggcccc ggcccactaa gaccagcttc gtgggctcct actacctgtg caaagacatg   1680

attaacaagc aggactgtaa gtacggggat aactgcacct tcgcctacca tcaggaggag   1740

atcgacgtgt ggaccgagga gcggaagggc accctcaacc gcgacctgct cttcgacccg   1800

ctggggggtg ttaagcgcgg cagcctcacc atcgccaagc tcctgaagga gcaccagggc   1860

atcttcacct tcctctgcga gatctgcttt gacagtaaac cccggatcat cagcaaaggc   1920

accaaggact ctccgtctgt ctgctccaac ctggctgcca agcacagctt ctacaacaac   1980

aagtgcctgg tgcacatcgt ccgctccacc tccctcaagt actccaagat ccgccagttc   2040

caggagcact tccagttcga cgtgtgccgc catgaggtgc gctacggctg cctgcgggag   2100

gacagctgcc acttcgccca cagcttcatc gagctcaagg tctggctgct gcagcagtac   2160

tcaggcatga cccacgaaga catcgttcag gagtctaaga agtactggca gcagatggag   2220

gcgcatgcgg ggaaggccag cagcagcatg ggtgctccga ggacacatgg gcccagcacc   2280

tttgacctgc agatgaagtt tgtatgtggc cagtgctgga gaaacgggca ggtggtggag   2340

cctgacaagg acctcaagta ctgtagtgcc aaggcccggc actgctggac caaggagcgg   2400

cgggtccttc tggtgatgtc caaggccaag aggaaatggg tgtcagtgag gccactgcca   2460

tccattcgta acttcccaca gcaatacgat ctctgcatcc atgcacagaa cggccgcaag   2520

tgccaatatg tggggaactg ctccttcgca cacagcccgg aggagaggga catgtggacc   2580

ttcatgaagg agaacaagat cctggacatg cagcagacct atgacatgtg gctgaaaaaa   2640

cacaacccag gaaagcctgg agaagggacc cccatcagtt ctcgggaagg ggagaagcag   2700

atccagatgc ccacggacta cgcggacatc atgatgggct accactgctg gctctgcggc   2760

aagaacagca acagcaagaa gcagtggcag cagcacatcc agtccgagaa gcacaaggag   2820

aaggtcttca cgtccgacag tgacgccagc ggctgggcct tccgcttccc catgggcgag   2880

ttccggctct gcgacaggct ccagaagggc aaagcctgcc cagatgggga caagtgccgc   2940

tgcgcccatg gacaggagga gctcaacgag tggctggacc ggcgcgaggt gctgaagcag   3000

aagttggcca aggctcgcaa ggacatgctg ctgtgcccac gggacgacga ctttggcaaa   3060

tacaacttcc tgctgcaaga ggacggggac cttgccggtg ccaccccaga agcccctgct   3120

gctgctgcca ccgccaccac tggggagtag ggccaggtgt tggccgtggg tgaagtcctg   3180

gggtcagggg gtggggtggg gccagaaggc ctgatagaag ggtcagggca ggccaggggg   3240

gtggggggcc gccctcatca ggcagccccc agccccctga ggccctgtcc atcttctccc   3300

caccaccgcc ccggtgtgcg tacccaggcg cacgtgctgc agcccccgga ggccccgctg   3360

aaacctgggc tgcccttccc ccacccccac ggctctcctg gttgaggagg gaggggcctg   3420

gctgacccct ccagcttcag cctccagctt taacttctgt ctgctcctaa tgggggccca   3480

aagctcaggg ctggggagcc tggggtcccc acttgaatct ccagcaggag ggtccttctc   3540

tccctggccc gtcctcctcc caccccctcc ccctgggggc aaatcaggac acaacagagg   3600

gcagaggccc cattagcttt aaaatgtagc cccaggttgg agctgggaac actgtactgg   3660

ccacttaccc tctggggcct cagctttccc tccggaaggc tgggaggagg tgggctagat   3720

gatctttgga gcttaaggag tcccagccct ttctctgatg ccaccacctg aaccctgctc   3780

cctcgtgggc cagtgaaaat agactgtagg tcctcagagc cttcagagat gatccagccc   3840

aaaccccatt ttgcagagag gaaaactgag gcctagaagg gaggagtggt ccacccacgg   3900

tcccagcaca aggcagagct gggatgaaaa cagggctgaa aagactcagg gccaattatt   3960

ggctgagccc acggtcccct cagcagggat gcgatggtct ctgaatcagt gtgcagctgg   4020

ggtcccaggc agcgctgcct gggggctggg gaggggaggc ccagaggagg gctggccatg   4080

tgagcacccc atgaagggac cgccccctcc caaggatggt ccctttgggt gcagcagcag   4140

aggtcacctc ctgacatgcg ctctgggaaa ggtggcagag ggcaggacac catgagctca   4200

ggatctgtgt gaggtgtggg aggtgggaag ggtgagggtc tgggggaatg cggagaaaag   4260

ggaggcttga ccccgggcac catgggccac tccaggatgg gacacggccc ctctttcttg   4320

gggacccagt atgtcctctc ctctagaccc agacatacag ttataaccgt ctgtcctagc   4380

ccctccctaa tccctggccc tcccagctgt ctgggacttc agtggacccc cagcccctgc   4440

ccccactcac caaggcctcg ctcgtccctc tcgtctgaca tgtctgtgtg cacccccctc   4500

ctctccaccc taccttccat caaccagggc agatccaccg tgccctggtt ccccagacat   4560

tccagaatgc cccacatcat tggcacagga gtggggcagc cccggaagga accagggatt   4620

aggctgtagg ggggtgagaa ggagagaagg gaccacccca ttcttctcaa gcaaggattg   4680

ccagcgcgcg ctgacacagt gatgggctgc ccagggctgg aggggacgct gttcctcccg   4740

ccgccactgc ccaacctttc ctgataatcg tggcatgcgc cctttcctct tccctgcccc   4800

accccctggc cgcagcaggc cagcactgca gagtttgggt gctggtggtg tggctgtagg   4860

ggaggggaga ccacacccaa ggtgggggct gtggccatgt gtggccgtga tgtcgatgat   4920

actcgttttc cctgatccgt ggtgttgcag tccgttgtca ccagccttgt ttctagtgtg   4980

tatatatgtc gcccccgtga tgcatatata cacaggtatt aaatatatcg ctctatataa   5040

tattatatat gtgtgtggta tccaaggaat cacttttatg agggctaaag ataaagaatt   5100

tggccagaaa atgcagccat ccttgtgtga ttaggagggt ttcaggggcc actggactat   5160

ttgcaaggtg acagggactg gagccatggc tcagaggtga ttcgggcagc cagggacagg   5220

agccaccctc cccaggccca actctgctag cttcccagac cacccccatc gagtgcggag   5280

agagtgggag tgctcaggga aagaaggtga tttgtatttg tctccccgct gaaaagaaca   5340

ggattcaagt ccagagtttt catcttcagc ctgtgatctg tccagggacc cttgggatct   5400

ggggcttcct ggcctggcca gagctggagc ccccacaggg taaggaagag agagtgggag   5460

gcagagtgtg atggggagga gggacaggaa gaccctttta atgatgaggg taactatttc   5520

agttgtgagc cttctagggc cccaggctgg gaggctcaga ggactgaatc tgggacctgt   5580

gttccccccg gcaggcaggg acaagatggc atggcaagca tgggggcggg gtgggtgggg   5640

agggatgctg catttctcag ctgggcagta atcaatttaa tggtccttta aaatgtctgt   5700

gtattaaaaa tttaagaata ccacacttta atattaaata ttcataaggt ctagtatctt   5760

gataataatg tagatgtttt aataacaatt tttgtccttc ttaaaataaa atgaaagaaa   5820

cttgcttccc ttagcctttg ttctagaaaa taaacttgtg cactttga                5868


<210>  4047
<211>  977
<212>  PRT
<213>  Homosapiens

<400>  4047

Met Glu Arg Gln Lys Arg Lys Ala Asp Ile Glu Lys Gly Leu Gln Phe 
1               5                   10                  15      


Ile Gln Ser Thr Leu Pro Leu Lys Gln Glu Glu Tyr Glu Ala Phe Leu 
            20                  25                  30          


Leu Lys Leu Val Gln Asn Leu Phe Ala Glu Gly Asn Asp Leu Phe Arg 
        35                  40                  45              


Glu Lys Asp Tyr Lys Gln Ala Leu Val Gln Tyr Met Glu Gly Leu Asn 
    50                  55                  60                  


Val Ala Asp Tyr Ala Ala Ser Asp Gln Val Ala Leu Pro Arg Glu Leu 
65                  70                  75                  80  


Leu Cys Lys Leu His Val Asn Arg Ala Ala Cys Tyr Phe Thr Met Gly 
                85                  90                  95      


Leu Tyr Glu Lys Ala Leu Glu Asp Ser Glu Lys Ala Leu Gly Leu Asp 
            100                 105                 110         


Ser Glu Ser Ile Arg Ala Leu Phe Arg Lys Ala Arg Ala Leu Asn Glu 
        115                 120                 125             


Leu Gly Arg His Lys Glu Ala Tyr Glu Cys Ser Ser Arg Cys Ser Leu 
    130                 135                 140                 


Ala Leu Pro His Asp Glu Ser Val Thr Gln Leu Gly Gln Glu Leu Ala 
145                 150                 155                 160 


Gln Lys Leu Gly Leu Arg Val Arg Lys Ala Tyr Lys Arg Pro Gln Glu 
                165                 170                 175     


Leu Glu Thr Phe Ser Leu Leu Ser Asn Gly Thr Ala Ala Gly Val Ala 
            180                 185                 190         


Asp Gln Gly Thr Ser Asn Gly Leu Gly Ser Ile Asp Asp Ile Glu Thr 
        195                 200                 205             


Asp Cys Tyr Val Asp Pro Arg Gly Ser Pro Ala Leu Leu Pro Ser Thr 
    210                 215                 220                 


Pro Thr Met Pro Leu Phe Pro His Val Leu Asp Leu Leu Ala Pro Leu 
225                 230                 235                 240 


Asp Ser Ser Arg Thr Leu Pro Ser Thr Asp Ser Leu Asp Asp Phe Ser 
                245                 250                 255     


Asp Gly Asp Val Phe Gly Pro Glu Leu Asp Thr Leu Leu Asp Ser Leu 
            260                 265                 270         


Ser Leu Val Gln Gly Gly Leu Ser Gly Ser Gly Val Pro Ser Glu Leu 
        275                 280                 285             


Pro Gln Leu Ile Pro Val Phe Pro Gly Gly Thr Pro Leu Leu Pro Pro 
    290                 295                 300                 


Val Val Gly Gly Ser Ile Pro Val Ser Ser Pro Leu Pro Pro Ala Ser 
305                 310                 315                 320 


Phe Gly Leu Val Met Asp Pro Ser Lys Lys Leu Ala Ala Ser Val Leu 
                325                 330                 335     


Asp Ala Leu Asp Pro Pro Gly Pro Thr Leu Asp Pro Leu Asp Leu Leu 
            340                 345                 350         


Pro Tyr Ser Glu Thr Arg Leu Asp Ala Leu Asp Ser Phe Gly Ser Thr 
        355                 360                 365             


Arg Gly Ser Leu Asp Lys Pro Asp Ser Phe Met Glu Glu Thr Asn Ser 
    370                 375                 380                 


Gln Asp His Arg Pro Pro Ser Gly Ala Gln Lys Pro Ala Pro Ser Pro 
385                 390                 395                 400 


Glu Pro Cys Met Pro Asn Thr Ala Leu Leu Ile Lys Asn Pro Leu Ala 
                405                 410                 415     


Ala Thr His Glu Phe Lys Gln Ala Cys Gln Leu Cys Tyr Pro Lys Thr 
            420                 425                 430         


Gly Pro Arg Ala Gly Asp Tyr Thr Tyr Arg Glu Gly Leu Glu His Lys 
        435                 440                 445             


Cys Lys Arg Asp Ile Leu Leu Gly Arg Leu Arg Ser Ser Glu Asp Gln 
    450                 455                 460                 


Thr Trp Lys Arg Ile Arg Pro Arg Pro Thr Lys Thr Ser Phe Val Gly 
465                 470                 475                 480 


Ser Tyr Tyr Leu Cys Lys Asp Met Ile Asn Lys Gln Asp Cys Lys Tyr 
                485                 490                 495     


Gly Asp Asn Cys Thr Phe Ala Tyr His Gln Glu Glu Ile Asp Val Trp 
            500                 505                 510         


Thr Glu Glu Arg Lys Gly Thr Leu Asn Arg Asp Leu Leu Phe Asp Pro 
        515                 520                 525             


Leu Gly Gly Val Lys Arg Gly Ser Leu Thr Ile Ala Lys Leu Leu Lys 
    530                 535                 540                 


Glu His Gln Gly Ile Phe Thr Phe Leu Cys Glu Ile Cys Phe Asp Ser 
545                 550                 555                 560 


Lys Pro Arg Ile Ile Ser Lys Gly Thr Lys Asp Ser Pro Ser Val Cys 
                565                 570                 575     


Ser Asn Leu Ala Ala Lys His Ser Phe Tyr Asn Asn Lys Cys Leu Val 
            580                 585                 590         


His Ile Val Arg Ser Thr Ser Leu Lys Tyr Ser Lys Ile Arg Gln Phe 
        595                 600                 605             


Gln Glu His Phe Gln Phe Asp Val Cys Arg His Glu Val Arg Tyr Gly 
    610                 615                 620                 


Cys Leu Arg Glu Asp Ser Cys His Phe Ala His Ser Phe Ile Glu Leu 
625                 630                 635                 640 


Lys Val Trp Leu Leu Gln Gln Tyr Ser Gly Met Thr His Glu Asp Ile 
                645                 650                 655     


Val Gln Glu Ser Lys Lys Tyr Trp Gln Gln Met Glu Ala His Ala Gly 
            660                 665                 670         


Lys Ala Ser Ser Ser Met Gly Ala Pro Arg Thr His Gly Pro Ser Thr 
        675                 680                 685             


Phe Asp Leu Gln Met Lys Phe Val Cys Gly Gln Cys Trp Arg Asn Gly 
    690                 695                 700                 


Gln Val Val Glu Pro Asp Lys Asp Leu Lys Tyr Cys Ser Ala Lys Ala 
705                 710                 715                 720 


Arg His Cys Trp Thr Lys Glu Arg Arg Val Leu Leu Val Met Ser Lys 
                725                 730                 735     


Ala Lys Arg Lys Trp Val Ser Val Arg Pro Leu Pro Ser Ile Arg Asn 
            740                 745                 750         


Phe Pro Gln Gln Tyr Asp Leu Cys Ile His Ala Gln Asn Gly Arg Lys 
        755                 760                 765             


Cys Gln Tyr Val Gly Asn Cys Ser Phe Ala His Ser Pro Glu Glu Arg 
    770                 775                 780                 


Asp Met Trp Thr Phe Met Lys Glu Asn Lys Ile Leu Asp Met Gln Gln 
785                 790                 795                 800 


Thr Tyr Asp Met Trp Leu Lys Lys His Asn Pro Gly Lys Pro Gly Glu 
                805                 810                 815     


Gly Thr Pro Ile Ser Ser Arg Glu Gly Glu Lys Gln Ile Gln Met Pro 
            820                 825                 830         


Thr Asp Tyr Ala Asp Ile Met Met Gly Tyr His Cys Trp Leu Cys Gly 
        835                 840                 845             


Lys Asn Ser Asn Ser Lys Lys Gln Trp Gln Gln His Ile Gln Ser Glu 
    850                 855                 860                 


Lys His Lys Glu Lys Val Phe Thr Ser Asp Ser Asp Ala Ser Gly Trp 
865                 870                 875                 880 


Ala Phe Arg Phe Pro Met Gly Glu Phe Arg Leu Cys Asp Arg Leu Gln 
                885                 890                 895     


Lys Gly Lys Ala Cys Pro Asp Gly Asp Lys Cys Arg Cys Ala His Gly 
            900                 905                 910         


Gln Glu Glu Leu Asn Glu Trp Leu Asp Arg Arg Glu Val Leu Lys Gln 
        915                 920                 925             


Lys Leu Ala Lys Ala Arg Lys Asp Met Leu Leu Cys Pro Arg Asp Asp 
    930                 935                 940                 


Asp Phe Gly Lys Tyr Asn Phe Leu Leu Gln Glu Asp Gly Asp Leu Ala 
945                 950                 955                 960 


Gly Ala Thr Pro Glu Ala Pro Ala Ala Ala Ala Thr Ala Thr Thr Gly 
                965                 970                 975     


Glu 
    


<210>  4048
<211>  4382
<212>  DNA
<213>  Homosapiens

<400>  4048
cggcagctgc agcgggtcgc acggctccgg cccatctcgg ggggcgggcg ggggaggcga     60

ggtgcgcgag ccgagtccgg ggcacgatgt ccgacgcggg cggcggaaag aagccgcctg    120

tggacccgca ggcaggaccc ggtccggggc cggggcgcgc agctggggaa aggggcctgt    180

cggggtcctt ccccctggtc ctgaagaagc tgatggagaa ccccccgcgc gaggcgcgcc    240

tcgataagga aaaggggaag gaaaagctgg aggaggacga ggccgcagcc gccagcacca    300

tggctgtctc agcctccctc atgccaccca tctgggacaa gaccatccca tatgatggcg    360

aatctttcca cctggagtac atggacctgg atgagttcct gctggagaat ggcatccccg    420

ccagccccac ccacctggcc cacaacctgc tgctgcctgt agcagagcta gaagggaagg    480

agtctgccag ctcttccaca gcatccccac catcctcctc cactgccatc tttcagccct    540

ctgaaaccgt gtccagcaca gaatcttccc tggagaagga gagggagact cccagtccca    600

tcgaccccaa ttgtgtggaa gtggatgtga acttcaatcc ggaccccgcc gacctggtgc    660

tctccagtgt gccaggcggg gagctcttca accctcggaa gcacaagttt gctgaggagg    720

acctgaagcc ccagcctatg atcaaaaagg ccaagaaggt ctttgtcccc gacgagcaga    780

aggatgaaaa gtactggaca agacgcaaga agaacaacgt ggcagctaaa cggtcacggg    840

atgcccggcg cctgaaagag aatcagatca ccatccgggc agccttcctg gagaaggaga    900

acacagccct gcggacggag gtggccgagc tacgcaagga ggtgggcaag tgcaagacca    960

tcgtgtccaa gtatgagacc aaatacgggc ccttgtaacc cgtgcccccc gcccgggcgg   1020

ggtactgcct gcacctcaga cctctgcctg ggggctccct gtaacccctc acacgcgtgg   1080

agacttatga ctcgtcgtgg gcgcatggcg gcgcacctgc tgcaggagcg gccacgtctc   1140

agcttcatta taccatggcc tgcgcacgtg gcgacgtccc tgaggggcca gtctcctcac   1200

tggtggggaa cgcaagagaa tctgcgtaga tgggtgactc agccttagtt tctattcttg   1260

gatgtcccag ttgaatcaga aggggacctc tggagtacac acctctctcc tgggcgctca   1320

gggtccctgg actctccctc agtctccagc ctgggctgcc gagggctatc tctgcagaat   1380

gagttgtgat cattgtcacc ctatgtcttc tcaggtagca gggcgcgttt ccacttaagg   1440

tgtgtctgtc acgcacctca ttctccccag acagtctttg agtaacatct gttcccatct   1500

tccttggaag caggacacac cagctcctcc gtcagtgtct gcatgggtag caggctgcag   1560

gagtggggtc tctgcacagc ctgggatggg gcttggggct ggggcctgca gcagaagtgt   1620

gcccagcgtt tctcggctcc cgcacccctt ttcccttatg gctctgaggc catcggctgt   1680

ctctgcattt cattggctgt ggaggagaga ctcctaggat ggctgctgtc tgagccatga   1740

gtgccagggc tgagagaggc ctcttcattt cctctccagg ctactcagag gccatgtgaa   1800

gctcgtttgt cccactagac caggcctctg ggcctgctct ttctttccac ccaatgtcca   1860

gtcttggatc atagatttaa aaggaaaacc cctcttatct aggaggcttt aacttcctgg   1920

accccaggat tcaccttcct agtggtgttt agaaaatgcc tccacagccc ccttccacca   1980

tgggcatgag agctggggtg tgtttcttga gaagctccct tttttcttgc tctgctcacc   2040

ggtgtggcct gggctggagt gcactctccc tgggggcagc tggggcctcg caattcttgc   2100

ttcaggatct ctcccatgcg agctgcccgg agggtgtcag cagggcaaga cacctagtct   2160

agagtcacca aggtcacagt gccactttca cgggatagca ggctcttggg acttttacac   2220

aggcctaggg tcccctcagt cttggtccca ggagatgggg gccactcgtg aggctggcca   2280

tgctgtggct tctcacagct gtggtctccc ctgcctcaca acgactcctt tctcttgtgt   2340

ggcgggactc gcccttttgc tgtgctcaga agattcactg aggaaactca tggaagcctc   2400

tgctcatttg ggtcactggg acacccctga gatgggtgtg tttatttgct cagggcgggc   2460

agcctatggt gaagaggaga cagaggcgat gggcgtgctt cgtcctccgt aacactggct   2520

ttatttaccg tggtggttca gagtcccagg ccctgacctc taaagacttt tcataacaga   2580

cgttaagacc aagccgtgga cctcacccca ggggaatgcc acggcccttt ggggacctgc   2640

acacccacct ctccggggga cttgacaagg ggccctgagg ccaagggagg tcactcctcc   2700

ctccaggccc ctgactttta ctttgtggtt ctctaaaaac catgtacaca ctttcactct   2760

attgtaacca cacagggcag gcgcatccag catgtcagtg tcctgccccg ggcagctctc   2820

cctcccgggc acgctccctc tggcctggtg gatcaccaag agggcggttc tcattttgtt   2880

attagtggaa gagccttgag cttaaaagct cttcattttc tttgccggaa agtatatggt   2940

ttgtgttttt gcagttttat ttttttaagg atggacacta aatctctggt gtccatgttc   3000

cgagcccggt ggctgggatg gtggctcgat gtgtctcctc tttatcccgc cctctgcctg   3060

tttggtgccc tcccttcttt cccccaggca gtgggtatcg ggttctttcc caaagtgctt   3120

acttggaaag agtgtggctg ctggactctt ttcgaaatgc ccctctgagt caggagcctg   3180

gtggggacaa gatggaggat gtccacagag gctgacctgt gggggaaaag aagtgctcag   3240

gtaaggttgt ctcctctcct gtcctaaaaa aatccatgct tgcaggagag ggttggtgcc   3300

tgctcagttt ctgtcgaggg aatgggagtc tcctcggctc cctcctgggc cctctgcttc   3360

ttggaggccg accgctggag actgcggctc ctgtgcttgg atctttgaca tctgtcagtc   3420

actggaggct agagaagttg actttacctt ggctttctgt gggttcccga tgggcttgga   3480

agtgccgtct acttcctaag catcctgtct aaagctttgt ggcaccctca gtgcaacctc   3540

agaacagaca aatcatgaat gagctggaac tttgcaagaa tattcatatt ataaatgtct   3600

catctgatgg aggaacgtgt gcatttagag agagggagag ttttcaaggt ttatggcaac   3660

tttgtggagg acctgggtaa ctcttaccct tggccaaagg aagaggtttt cctgtctggc   3720

ttctgaggtt ggagggggca cttagcagtg aaccttaagt ctgggtacat gtaaccctgc   3780

tgaggggctg tgcaggccgc tcctacggtc ctttggcctg aggcagggcg ggaggcatgc   3840

aagccagtgg gggaaaaccc ctctgaagct gggcagccct ctacctgggc cccgggagcc   3900

gtgctccttg gaacgcaaag ggccgaggag catctggttt tcatggcaaa gctctactcc   3960

agagctcctt taacatctgc taattaagtg caataaattt ttctagaaaa tggcaaagat   4020

gacttccagg tggatattgc tctcttacgg tgttggggat gccagaacac cacttggttt   4080

tatttttcta agtgcatgtg atgtgataga gtgtgtgggg ctctgtgtcc ttccctggga   4140

gctggcattc cagcgggccc ctctctttac ctttgttggg ggaaggaggc aagagagaaa   4200

ttccttcttc ccagccagag agggcagaag cagaccgtag cccattggcc ttatgtgcgt   4260

gtgtgcgtgc gagtgtgtca ctgctggtgg gccggagtga tgtggtggga gggaagccgg   4320

gaatgtatcc ttttcagaca aaattaaata ttttgaaatg agaaaaaaaa aaaaaaaaaa   4380

aa                                                                  4382


<210>  4049
<211>  303
<212>  PRT
<213>  Homosapiens

<400>  4049

Met Ser Asp Ala Gly Gly Gly Lys Lys Pro Pro Val Asp Pro Gln Ala 
1               5                   10                  15      


Gly Pro Gly Pro Gly Pro Gly Arg Ala Ala Gly Glu Arg Gly Leu Ser 
            20                  25                  30          


Gly Ser Phe Pro Leu Val Leu Lys Lys Leu Met Glu Asn Pro Pro Arg 
        35                  40                  45              


Glu Ala Arg Leu Asp Lys Glu Lys Gly Lys Glu Lys Leu Glu Glu Asp 
    50                  55                  60                  


Glu Ala Ala Ala Ala Ser Thr Met Ala Val Ser Ala Ser Leu Met Pro 
65                  70                  75                  80  


Pro Ile Trp Asp Lys Thr Ile Pro Tyr Asp Gly Glu Ser Phe His Leu 
                85                  90                  95      


Glu Tyr Met Asp Leu Asp Glu Phe Leu Leu Glu Asn Gly Ile Pro Ala 
            100                 105                 110         


Ser Pro Thr His Leu Ala His Asn Leu Leu Leu Pro Val Ala Glu Leu 
        115                 120                 125             


Glu Gly Lys Glu Ser Ala Ser Ser Ser Thr Ala Ser Pro Pro Ser Ser 
    130                 135                 140                 


Ser Thr Ala Ile Phe Gln Pro Ser Glu Thr Val Ser Ser Thr Glu Ser 
145                 150                 155                 160 


Ser Leu Glu Lys Glu Arg Glu Thr Pro Ser Pro Ile Asp Pro Asn Cys 
                165                 170                 175     


Val Glu Val Asp Val Asn Phe Asn Pro Asp Pro Ala Asp Leu Val Leu 
            180                 185                 190         


Ser Ser Val Pro Gly Gly Glu Leu Phe Asn Pro Arg Lys His Lys Phe 
        195                 200                 205             


Ala Glu Glu Asp Leu Lys Pro Gln Pro Met Ile Lys Lys Ala Lys Lys 
    210                 215                 220                 


Val Phe Val Pro Asp Glu Gln Lys Asp Glu Lys Tyr Trp Thr Arg Arg 
225                 230                 235                 240 


Lys Lys Asn Asn Val Ala Ala Lys Arg Ser Arg Asp Ala Arg Arg Leu 
                245                 250                 255     


Lys Glu Asn Gln Ile Thr Ile Arg Ala Ala Phe Leu Glu Lys Glu Asn 
            260                 265                 270         


Thr Ala Leu Arg Thr Glu Val Ala Glu Leu Arg Lys Glu Val Gly Lys 
        275                 280                 285             


Cys Lys Thr Ile Val Ser Lys Tyr Glu Thr Lys Tyr Gly Pro Leu 
    290                 295                 300             


<210>  4050
<211>  4575
<212>  DNA
<213>  Homosapiens

<400>  4050
cagggagggg aagacgggga gccggacgca cgaccggcga gcacagaagg gcacaggagc     60

tgctccgcga gataccagcg agctgaggcg cggggctggc tgggaagtag tcccggccgg    120

gccctggccc cgcccctgca gggcggaggg acgcatcacg caggggtggg gaagccggat    180

ccgtgcgcag ggttgctaag ggtgaaactt ttcattgact ttgctcactt cgggccgggg    240

cgcgggaagg tgcgggttgt tggctgaggc aagccgtggc tcgggcgacg cggggccagg    300

agggcaggac cgtctgccgg cgacagccca taccgtctgc cgttgcgcga cacgaaccac    360

cctccgatcc gccatccccg cgtcgtcgcc gctagtccgc ccgcccgccc tcgggccccc    420

cgctgccgag cccgacctcc taagagctga aagaaattat tgagagtcat agtccatagc    480

cccctgcttc gtcccccaac cctcaacgac gaaaaggact tcggtcccct ggcccggcga    540

cgcccgggaa ggaaaggaga gcgacctccg ccccgcgctc aggccaccct ggagggagaa    600

gccgccccgc ggccggtaga gcgccccgcc gccgcggaga cccgaagccg cctggagccc    660

aaggctgtac acgtgccctg tgctgattct ctgcctagga aaggaccatg cagctagaga    720

tcaaagtggc cctgaacttc atcatctcct acttgtacaa caagctgccc cggcgccggg    780

cagacctgtt tggggaggag ctagagcggc ttttgaaaaa gaaatatgaa ggccactggt    840

accctgagaa gccactgaaa ggctctggct tccgctgtgt tcacattggg gagatggtgg    900

accccgtggt ggagctggcc gccaagcgga gtggcctggc ggtggaagat gtgcgggcca    960

atgtgcctga ggagctgagt gtctggattg atccctttga ggtgtcctac cagattggtg   1020

agaagggagc tgtgaaagtg ctgtacctgg atgacagtga gggttgcggt gccccagagc   1080

tggacaagga gatcaagagc agcttcaacc ctgacgccca ggtgttcgtg cccattggca   1140

gccaggacag ctccctgtcc aactccccat cgccatcctt tggccagtca cccagcccta   1200

ccttcattcc ccgctccgct cagcccatca ccttcaccac cgcctccttc gctgccacca   1260

aatttggctc cactaagatg aagaaggggg gcggggcagc aagtggtggg ggtgtagcca   1320

gcagtggggc gggtggccag cagccaccac agcagcctcg catggcccgc tcacccacca   1380

acagcctgct gaagcacaag agcctctctc tgtctatgca ttcactgaac ttcatcacgg   1440

ccaacccggc ccctcagtcc cagctctcac ccaatgccaa ggagttcgtg tacaacggtg   1500

gtggctcacc cagcctcttc tttgatgcgg ccgatggcca gggcagcggc accccaggcc   1560

cgtttggagg cagtggggct ggcacctgca acagcagcag ctttgacatg gcccaggtat   1620

ttggaggtgg tgccaacagc ctcttcctgg agaagacacc ctttgtggaa ggcctcagct   1680

acaacctgaa caccatgcag tatcccagcc agcagttcca gcccgtggtg ctggccaact   1740

gaccatctac ctgcccgtgg ggccaggagc acccaagacc acagaaaaga gaaaggaaag   1800

gccaaaaaaa agaggaaaag aaaaatgtac aaaaagattt tcgatcttct cactcttact   1860

tctagaaaaa agatccagcc caggcacgga atgggagggc cctgcaaagc acccaagtgt   1920

gtttcactca ccccttaccg ctcgcccacc ggcctgtgat ttatttggtt ggtttgggtt   1980

ttatatttct ttttcttttt tttttttctt acatgtagtt ttctatataa catctttaat   2040

gagtggcttc ctgtgctaag aatggtccag atgtgaactg ctgctccctg ctcctccctt   2100

cctccttcac actcctagtt taggattgat gtgtccaagc tcatagggaa gaaagagctg   2160

cagctggagc ctgaccctcc ctggaacagg gagaggctgg cccgtgtcac tgcctctgtc   2220

acccagctat cctcgcactc aaagccatcc aacctcagca ggccttctcg ggccctgcca   2280

cctgaatagg tctgacccca gtccccactc cctttcaggc tgggccacag ggagttgctg   2340

gctggccact tgacaccctc cccctggagc tgatgtctgt gactacaggg agattagcac   2400

ttcgtctagt gaaactcctt tcatctctgt cctatggccc caccccacca ttccctctag   2460

gcccagacca tcatcatggc cctggccatt gatgtgtatg ggctttcttt ccctcatgca   2520

gccccttctt ccccaggctg gatgttgtgg gtagggaggg gtgtgtgtgt gtgtatttgg   2580

tttgctgtcc ttttttaaag gattccaagc catgtgaaac ttcccttctg gatgtgattc   2640

tgggtcgcaa gtccttattt atatgtgagg ctggggaatg ggctgggggt attggcagtc   2700

cttttgcagg gcagtgtgtg tggtggggtg acaccgctgt ggcttagccc aagacactcc   2760

cagaggaaaa cactgcagaa ggaactggtt tgcagactgt ggaaggatct gcagttttgt   2820

ttttgaccaa aaaaataata ataagttagc tctgaagggc agagggaata cccaagcccc   2880

tgatgcctat gagaagtccc tggacttcaa ccctcctgtt gtttggcctt agcccagagg   2940

gagctgctca cctgagcacc cttgggggtg ggcagagagg cagggtggga ttttagagtt   3000

agtgtctgtg cgggggcagc cctgagcctg gagttgagac tttggggtct cttagtttgg   3060

aggtgttgag tgcatttgtg cccctgcctg gttgagagct tcttggtacc tcttgccacc   3120

ccttctcact gccctgaccc aaccccactg gaccttgatg ctgcgaggag tggtgtcctg   3180

acggactcag cactcccgcc tgatgtattg gatcatagga gagcacttgc tctcctgcct   3240

ctgccaggag agggcttgtt cctccaactc taggaggcca ggcaagcatg gacaggagcc   3300

aagggagcag ggtcattaac tttttcttct ttgcaaagtg ggcacttggc atcagggtcc   3360

caatcaccag aaagcaccaa agcccctggc accccaccca ctccatccta cccagggacc   3420

ccaagtaggc aactgttatg gcagtgggtc cagcccaggc cagcactgcc agcctcctct   3480

ccctgcagta ggcaccagct ctacctcccc cggcaggcaa tgtcctggct tctcagccca   3540

gcaccatctg ttcccctaga cttctcaggg gccagcccag tctgggccac cctttgtttc   3600

cctcatcctc ggctcccaca caggtgacag acccagcaga tagcttctct ctgggaaagg   3660

ttggatgctg ccttacatcc ccttctagcc ctcctcccat ccacacacac aggcacccac   3720

ccacaccagg tcggcttgtt tctcacatgt agggagagag gggagaccaa cccctttgtg   3780

tcttttgaaa tacgaagaaa aatgtgtgtt caggagcatg actccagtgc tgcgctcttg   3840

ggcccagttc agtctgtctt gtctcaaatc taggcatttt tgcttcaatt ttattttttt   3900

taagaataca aaaacagaaa tctgcactaa tttacctggt ttcgtaggaa aacttttttt   3960

tattttttac attttttggt gtccgtttgt attgaataat ttgctacatt tgtaaaatgt   4020

aagaggtata taatatatgt atatttctaa cgtaaaaaac ataatttttt tcttttcaag   4080

attttttctt aaaaagatga gagaaacata ttttttcagg aaaaacaaac tttaaaaaaa   4140

aaagaggaga aataaaacct tttctcccct ttccccatcc tctatctatc cctctttccc   4200

aggaacaaat caaaaggtgg attatcttct gaagaatgga aactgttagt ccagaatgat   4260

gtgtttttct caatgcagtg agttatagat tctctagttt tctccctagg gatgggaagg   4320

gggcattgag gcaagcctgg agaggagccc ggggagcagg gtcatgaact tttttcttta   4380

gtgaaggagg aatacaatca agggttttgt attcagaatg ttgtgcaata ttttggaatg   4440

ggacattggt gtgtttagag attttagttt aaaaacaaaa caaaaagatt gatcaaatct   4500

gtacagtttc tattgttcca gattttttta agtttgtatt aaaagcatga tacataatag   4560

ccttcaaaaa aaaaa                                                    4575


<210>  4051
<211>  344
<212>  PRT
<213>  Homosapiens

<400>  4051

Met Gln Leu Glu Ile Lys Val Ala Leu Asn Phe Ile Ile Ser Tyr Leu 
1               5                   10                  15      


Tyr Asn Lys Leu Pro Arg Arg Arg Ala Asp Leu Phe Gly Glu Glu Leu 
            20                  25                  30          


Glu Arg Leu Leu Lys Lys Lys Tyr Glu Gly His Trp Tyr Pro Glu Lys 
        35                  40                  45              


Pro Leu Lys Gly Ser Gly Phe Arg Cys Val His Ile Gly Glu Met Val 
    50                  55                  60                  


Asp Pro Val Val Glu Leu Ala Ala Lys Arg Ser Gly Leu Ala Val Glu 
65                  70                  75                  80  


Asp Val Arg Ala Asn Val Pro Glu Glu Leu Ser Val Trp Ile Asp Pro 
                85                  90                  95      


Phe Glu Val Ser Tyr Gln Ile Gly Glu Lys Gly Ala Val Lys Val Leu 
            100                 105                 110         


Tyr Leu Asp Asp Ser Glu Gly Cys Gly Ala Pro Glu Leu Asp Lys Glu 
        115                 120                 125             


Ile Lys Ser Ser Phe Asn Pro Asp Ala Gln Val Phe Val Pro Ile Gly 
    130                 135                 140                 


Ser Gln Asp Ser Ser Leu Ser Asn Ser Pro Ser Pro Ser Phe Gly Gln 
145                 150                 155                 160 


Ser Pro Ser Pro Thr Phe Ile Pro Arg Ser Ala Gln Pro Ile Thr Phe 
                165                 170                 175     


Thr Thr Ala Ser Phe Ala Ala Thr Lys Phe Gly Ser Thr Lys Met Lys 
            180                 185                 190         


Lys Gly Gly Gly Ala Ala Ser Gly Gly Gly Val Ala Ser Ser Gly Ala 
        195                 200                 205             


Gly Gly Gln Gln Pro Pro Gln Gln Pro Arg Met Ala Arg Ser Pro Thr 
    210                 215                 220                 


Asn Ser Leu Leu Lys His Lys Ser Leu Ser Leu Ser Met His Ser Leu 
225                 230                 235                 240 


Asn Phe Ile Thr Ala Asn Pro Ala Pro Gln Ser Gln Leu Ser Pro Asn 
                245                 250                 255     


Ala Lys Glu Phe Val Tyr Asn Gly Gly Gly Ser Pro Ser Leu Phe Phe 
            260                 265                 270         


Asp Ala Ala Asp Gly Gln Gly Ser Gly Thr Pro Gly Pro Phe Gly Gly 
        275                 280                 285             


Ser Gly Ala Gly Thr Cys Asn Ser Ser Ser Phe Asp Met Ala Gln Val 
    290                 295                 300                 


Phe Gly Gly Gly Ala Asn Ser Leu Phe Leu Glu Lys Thr Pro Phe Val 
305                 310                 315                 320 


Glu Gly Leu Ser Tyr Asn Leu Asn Thr Met Gln Tyr Pro Ser Gln Gln 
                325                 330                 335     


Phe Gln Pro Val Val Leu Ala Asn 
            340                 


<210>  4052
<211>  1105
<212>  DNA
<213>  Homosapiens

<400>  4052
aggtcggacg gaagttcccg aagcttccgg tggccggctt agttaggagc tatggctaaa     60

catcatcctg atttgatctt ttgccgcaag caggctggtg ttgccatcgg aagactgtgt    120

gaaaaatgtg atggcaagtg tgtgatttgt gactcctatg tgcgtccctg cactctggtg    180

cgcatatgtg atgagtgtaa ctatggatct taccaggggc gctgtgtgat ctgtggagga    240

cctggggtct ctgatgccta ttattgtaag gagtgcacca tccaggagaa ggacagagat    300

ggctgcccaa agattgtcaa tctggggagc tctaagacag acctcttcta tgaacgcaaa    360

aaatacggct tcaagaagag gtgattggtg ggtggcccct tcctcccccc aacatcagtc    420

tgctgcagct gccagaaaac atgcctacta ctaccagcag aaagggagca gagcccagag    480

catcaccagg agtgcctgct agtgtactgg cagcttgcca ccccctcctc tcccttcacc    540

cagacacgtg gtagggatgg aaaaggattc ttcacagagc actctggcac accatatcgg    600

agaaaacttg atagattagt taatggtttt tcttgaattc gagaagcaaa gatctgttct    660

ccatattggt atgttctccc tcaaccaaga tcttctaaaa agaaataata ttttagtctt    720

ctgcttgagg aactgactgt gaagcgacgc ccagtgaaaa acatgttctt gcagcagctc    780

tggtggcagc tgtccttgag gaacctttgg tgtgtggtgg gaagctatca gaacaagaaa    840

tgtaggcatt tcccgttttt tttggggggg gggtgggggg gcagggctct gccctcttga    900

aaggcattta cttgtttaac acttgtccag ctacagtggg gtacagtagc tggctattca    960

caggcatcat catagcccac tagtctcata ttattttcct tttgagaaat tggaaactct   1020

ttctgttgct attatattaa taaagttggt gtttattttc tggtaaaaaa aaaaaaaaaa   1080

aaaaaaaaaa aaaaaaaaaa aaaaa                                         1105


<210>  4053
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  4053

Met Ala Lys His His Pro Asp Leu Ile Phe Cys Arg Lys Gln Ala Gly 
1               5                   10                  15      


Val Ala Ile Gly Arg Leu Cys Glu Lys Cys Asp Gly Lys Cys Val Ile 
            20                  25                  30          


Cys Asp Ser Tyr Val Arg Pro Cys Thr Leu Val Arg Ile Cys Asp Glu 
        35                  40                  45              


Cys Asn Tyr Gly Ser Tyr Gln Gly Arg Cys Val Ile Cys Gly Gly Pro 
    50                  55                  60                  


Gly Val Ser Asp Ala Tyr Tyr Cys Lys Glu Cys Thr Ile Gln Glu Lys 
65                  70                  75                  80  


Asp Arg Asp Gly Cys Pro Lys Ile Val Asn Leu Gly Ser Ser Lys Thr 
                85                  90                  95      


Asp Leu Phe Tyr Glu Arg Lys Lys Tyr Gly Phe Lys Lys Arg 
            100                 105                 110 


<210>  4054
<211>  2744
<212>  DNA
<213>  Homosapiens

<400>  4054
ctcatctttg tcagtgcaca aaatggcgcc ctacagccta ctggtgactc ggctgcagaa     60

agctctgggt gtgcggcagt accatgtggc ctcagtcctg tgccaacggg ccaaggtggc    120

gatgagccac tttgagccca acgagtacat ccattatgac ctgctagaga agaacattaa    180

cattgttcgc aaacgactga accggccgct gacactctcg gagaagattg tgtatggaca    240

cctggatgac cccgccagcc aggaaattga gcgaggcaag tcgtacctgc ggctgcggcc    300

ggaccgtgtg gccatgcagg atgcgacggc ccagatggcc atgctccagt tcatcagcag    360

cgggctgtcc aaggtggctg tgccatccac catccactgt gaccatctga ttgaagccca    420

ggttgggggc gagaaagacc tgcgccgggc caaggacatc aaccaggaag tttataattt    480

cctggcaact gcaggtgcca aatatggcgt gggcttctgg aagcctggat ctggaatcat    540

tcaccagatt attctggaaa actatgcgta ccctggtgtt cttctgattg gcactgactc    600

ccacaccccc aatggtggcg gccttggggg catctgcatt ggagttgggg gtgccgatgc    660

tgtggatgtc atggctggga tcccctggga gctgaagtgc cccaaggtga ttggcgtgaa    720

gctgacgggc tctctctccg gttggtcctc acccaaagat gtgatcctga aggtggcagg    780

catcctcacg gtgaaaggtg gcacaggtgc aatcgtggaa taccacgggc ctggtgtaga    840

ctccatctcc tgcactggca tggcgacaat ctgcaacatg ggtgcagaaa ttggggccac    900

cacttccgtg ttcccttaca accacaggat gaagaagtac ctgagcaaga ccggccggga    960

agacattgcc aatctagctg atgaattcaa ggatcacttg gtgcctgacc ctggctgcca   1020

ttatgaccaa ctaattgaaa ttaacctcag tgagctgaag ccacacatca atgggccctt   1080

cacccctgac ctggctcacc ctgtggcaga agtgggcaag gtggcagaga aggaaggatg   1140

gcctctggac atccgagtgg gtctaattgg tagctgcacc aattcaagct atgaagatat   1200

ggggcgctca gcagctgtgg ccaagcaggc actggcccat ggcctcaagt gcaagtccca   1260

gttcaccatc actccaggtt ccgagcagat ccgcgccacc attgagcggg acggctatgc   1320

acagatcttg agggatctgg gtggcattgt cctggccaat gcttgtggcc cctgcattgg   1380

ccagtgggac aggaaggaca tcaagaaggg ggagaagaac acaatcgtca cctcctacaa   1440

caggaacttc acgggccgca acgacgcaaa ccccgagacc catgcctttg tcacgtcccc   1500

agagattgtc acagccctgg ccattgcggg aaccctcaag ttcaacccag agaccgacta   1560

cctgacgggc acggatggca agaagttcag gctggaggct ccggatgcag atgagcttcc   1620

caaaggggag tttgacccag ggcaggacac ctaccagcac ccacccaagg acagcagcgg   1680

gcagcatgtg gacgtgagcc ccaccagcca gcgcctgcag ctcctggagc cttttgacaa   1740

gtgggatggc aaggacctgg aggacctgca gatcctcatc aaggtcaaag ggaagtgtac   1800

cactgaccac atctcagctg ctggcccctg gctcaagttc cgtgggcact tggataacat   1860

ctccaacaac ctgctcattg gtgccatcaa cattgaaaac ggcaaggcca actccgtgcg   1920

caatgccgtc actcaggagt ttggccccgt ccctgacact gcccgctact acaagaaaca   1980

tggcatcagg tgggtggtga tcggagacga gaactacggc gagggctcga gccgggagca   2040

tgcagctctg gagcctcgcc accttggggg ccgggccatc atcaccaaga gctttgccag   2100

gatccacgag accaacctga agaaacaggg cctgctgcct ctgaccttcg ctgacccggc   2160

tgactacaac aagattcacc ctgtggacaa gctgaccatt cagggcctga aggacttcac   2220

ccctggcaag cccctgaagt gcatcatcaa gcaccccaac gggacccagg agaccatcct   2280

cctgaaccac accttcaacg agacgcagat tgagtggttc cgcgctggca gtgccctcaa   2340

cagaatgaag gaactgcaac agtgagggca gtgcctcccc gccccgccgc tggcgtcaag   2400

ttcagctcca cgtgtgccat cagtggatcc gatccgtcca gccatggctt cctattccaa   2460

gatggtgtga ccagacatgc ttcctgctcc ccgcttagcc cacggagtga ctgtggttgt   2520

ggtggggggg ttcttaaaat aactttttag cccccgtctt cctattttga gtttggttca   2580

gatcttaagc agctccatgc aactgtattt atttttgatg acaagactcc catctaaagt   2640

ttttctcctg cctgatcatt tcattggtgg ctgaaggatt ctagagaacc ttttgttctt   2700

gcaaggaaaa caagaatcca aaaccagtga ctgttctgtg aaaa                    2744


<210>  4055
<211>  780
<212>  PRT
<213>  Homosapiens

<400>  4055

Met Ala Pro Tyr Ser Leu Leu Val Thr Arg Leu Gln Lys Ala Leu Gly 
1               5                   10                  15      


Val Arg Gln Tyr His Val Ala Ser Val Leu Cys Gln Arg Ala Lys Val 
            20                  25                  30          


Ala Met Ser His Phe Glu Pro Asn Glu Tyr Ile His Tyr Asp Leu Leu 
        35                  40                  45              


Glu Lys Asn Ile Asn Ile Val Arg Lys Arg Leu Asn Arg Pro Leu Thr 
    50                  55                  60                  


Leu Ser Glu Lys Ile Val Tyr Gly His Leu Asp Asp Pro Ala Ser Gln 
65                  70                  75                  80  


Glu Ile Glu Arg Gly Lys Ser Tyr Leu Arg Leu Arg Pro Asp Arg Val 
                85                  90                  95      


Ala Met Gln Asp Ala Thr Ala Gln Met Ala Met Leu Gln Phe Ile Ser 
            100                 105                 110         


Ser Gly Leu Ser Lys Val Ala Val Pro Ser Thr Ile His Cys Asp His 
        115                 120                 125             


Leu Ile Glu Ala Gln Val Gly Gly Glu Lys Asp Leu Arg Arg Ala Lys 
    130                 135                 140                 


Asp Ile Asn Gln Glu Val Tyr Asn Phe Leu Ala Thr Ala Gly Ala Lys 
145                 150                 155                 160 


Tyr Gly Val Gly Phe Trp Lys Pro Gly Ser Gly Ile Ile His Gln Ile 
                165                 170                 175     


Ile Leu Glu Asn Tyr Ala Tyr Pro Gly Val Leu Leu Ile Gly Thr Asp 
            180                 185                 190         


Ser His Thr Pro Asn Gly Gly Gly Leu Gly Gly Ile Cys Ile Gly Val 
        195                 200                 205             


Gly Gly Ala Asp Ala Val Asp Val Met Ala Gly Ile Pro Trp Glu Leu 
    210                 215                 220                 


Lys Cys Pro Lys Val Ile Gly Val Lys Leu Thr Gly Ser Leu Ser Gly 
225                 230                 235                 240 


Trp Ser Ser Pro Lys Asp Val Ile Leu Lys Val Ala Gly Ile Leu Thr 
                245                 250                 255     


Val Lys Gly Gly Thr Gly Ala Ile Val Glu Tyr His Gly Pro Gly Val 
            260                 265                 270         


Asp Ser Ile Ser Cys Thr Gly Met Ala Thr Ile Cys Asn Met Gly Ala 
        275                 280                 285             


Glu Ile Gly Ala Thr Thr Ser Val Phe Pro Tyr Asn His Arg Met Lys 
    290                 295                 300                 


Lys Tyr Leu Ser Lys Thr Gly Arg Glu Asp Ile Ala Asn Leu Ala Asp 
305                 310                 315                 320 


Glu Phe Lys Asp His Leu Val Pro Asp Pro Gly Cys His Tyr Asp Gln 
                325                 330                 335     


Leu Ile Glu Ile Asn Leu Ser Glu Leu Lys Pro His Ile Asn Gly Pro 
            340                 345                 350         


Phe Thr Pro Asp Leu Ala His Pro Val Ala Glu Val Gly Lys Val Ala 
        355                 360                 365             


Glu Lys Glu Gly Trp Pro Leu Asp Ile Arg Val Gly Leu Ile Gly Ser 
    370                 375                 380                 


Cys Thr Asn Ser Ser Tyr Glu Asp Met Gly Arg Ser Ala Ala Val Ala 
385                 390                 395                 400 


Lys Gln Ala Leu Ala His Gly Leu Lys Cys Lys Ser Gln Phe Thr Ile 
                405                 410                 415     


Thr Pro Gly Ser Glu Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Tyr 
            420                 425                 430         


Ala Gln Ile Leu Arg Asp Leu Gly Gly Ile Val Leu Ala Asn Ala Cys 
        435                 440                 445             


Gly Pro Cys Ile Gly Gln Trp Asp Arg Lys Asp Ile Lys Lys Gly Glu 
    450                 455                 460                 


Lys Asn Thr Ile Val Thr Ser Tyr Asn Arg Asn Phe Thr Gly Arg Asn 
465                 470                 475                 480 


Asp Ala Asn Pro Glu Thr His Ala Phe Val Thr Ser Pro Glu Ile Val 
                485                 490                 495     


Thr Ala Leu Ala Ile Ala Gly Thr Leu Lys Phe Asn Pro Glu Thr Asp 
            500                 505                 510         


Tyr Leu Thr Gly Thr Asp Gly Lys Lys Phe Arg Leu Glu Ala Pro Asp 
        515                 520                 525             


Ala Asp Glu Leu Pro Lys Gly Glu Phe Asp Pro Gly Gln Asp Thr Tyr 
    530                 535                 540                 


Gln His Pro Pro Lys Asp Ser Ser Gly Gln His Val Asp Val Ser Pro 
545                 550                 555                 560 


Thr Ser Gln Arg Leu Gln Leu Leu Glu Pro Phe Asp Lys Trp Asp Gly 
                565                 570                 575     


Lys Asp Leu Glu Asp Leu Gln Ile Leu Ile Lys Val Lys Gly Lys Cys 
            580                 585                 590         


Thr Thr Asp His Ile Ser Ala Ala Gly Pro Trp Leu Lys Phe Arg Gly 
        595                 600                 605             


His Leu Asp Asn Ile Ser Asn Asn Leu Leu Ile Gly Ala Ile Asn Ile 
    610                 615                 620                 


Glu Asn Gly Lys Ala Asn Ser Val Arg Asn Ala Val Thr Gln Glu Phe 
625                 630                 635                 640 


Gly Pro Val Pro Asp Thr Ala Arg Tyr Tyr Lys Lys His Gly Ile Arg 
                645                 650                 655     


Trp Val Val Ile Gly Asp Glu Asn Tyr Gly Glu Gly Ser Ser Arg Glu 
            660                 665                 670         


His Ala Ala Leu Glu Pro Arg His Leu Gly Gly Arg Ala Ile Ile Thr 
        675                 680                 685             


Lys Ser Phe Ala Arg Ile His Glu Thr Asn Leu Lys Lys Gln Gly Leu 
    690                 695                 700                 


Leu Pro Leu Thr Phe Ala Asp Pro Ala Asp Tyr Asn Lys Ile His Pro 
705                 710                 715                 720 


Val Asp Lys Leu Thr Ile Gln Gly Leu Lys Asp Phe Thr Pro Gly Lys 
                725                 730                 735     


Pro Leu Lys Cys Ile Ile Lys His Pro Asn Gly Thr Gln Glu Thr Ile 
            740                 745                 750         


Leu Leu Asn His Thr Phe Asn Glu Thr Gln Ile Glu Trp Phe Arg Ala 
        755                 760                 765             


Gly Ser Ala Leu Asn Arg Met Lys Glu Leu Gln Gln 
    770                 775                 780 


<210>  4056
<211>  4465
<212>  DNA
<213>  Homosapiens

<400>  4056
gggcaaagcg cgagcggctg tgcgcggtgc gtggtgcgtg gtgcgtgata cgagcggcgg     60

cacgtggcgc gggtgcgggg cgtggagtgg cgtggcgtgg agtggcgtgg cgtggcgggg    120

tctcgcggcg cgggcgcgca cccggagctg tggacggaga gtgcctccct ctggcctcag    180

tttcctcatg ttgtagtagc ggagcatggc ccggaccggg cccccgagac cgccccgtgc    240

aacctcaccg ccagcctggg ggcctcagcg actgggacgg gaccaagggg ctcggggatt    300

ctccctgccc ccggccctgg tgcgtgactg accctcctgt tcccagagcc cccagcgcag    360

gccgggatgt tcgtcctggt ggaaatggtg gacaccgtcc ggatcccccc ttggcagttt    420

gagaggaagc tcaacgactc cattgccgag gagctgaaca agaagttggc caacaaggtc    480

gtgtacaacg tgggactctg catttgtctg tttgatatca ccaaactgga ggatgcctat    540

gtattccctg gggatggcgc atcacacacc aaagtccatt ttcgctgcgt ggtgtttcat    600

ccattcctag atgagattct cattgggaag atcaaaggct gcagcccaga aggagtgcac    660

gtctctctag gcttcttcga tgacattctc atccccccag agtcactgca gcagccagcc    720

aagttcgacg aagcggagca ggtgtgggtg tgggagtacg agacggagga aggagcacac    780

gacctctaca tggacaccgg cgaggagatc cgcttccggg tggtggacga gagctttgtt    840

gacacgtccc ccacagggcc cagctcagca gatgccacca cttccagtga ggagctgcca    900

aagaaggagg ctccgtacac gcttgtggga tccatcagtg agccaggcct gggccttctc    960

tcctggtgga ccagcaacta gccctggggc tggacagtgg accctaccag cctgcgggaa   1020

ggtggtatgg ccggctgtga agacaacagc agctgaggcc gatgctaagg agatagtgtc   1080

tcgagctgga cagtgaggca aggccaggag tgcccaccag cttgccccgc tcctccacca   1140

tctaggccct gctcctcctt cactgcagtg atggatccat ctgtggctgt ggctgttggg   1200

cctccactga ccttgactga aaagaccctt cctggaccct ggacttgaca acaaacggca   1260

cagacaccaa tcactcacag aacagtcact ggttttggat tcttgttttc cttgcaagaa   1320

caaaaggttc tctagaatcc ttcagccacc aatgaaatga tcaggcagga gaaaaacttt   1380

agatgggagt cttgtcatca aaaataaata cagttgcatg gagctgctta agatctgaac   1440

caaactcaaa ataggaagac gggggctaaa aagttatttt aagaaccccc ccaccacaac   1500

cacagtcact ccgtgggcta agcggggagc aggaagcatg tctggtcaca ccatcttgga   1560

ataggaagcc atggctggac ggatcggatc cactgatggc acacgtggag ctgaacttga   1620

cgccagcggc ggggcgggga ggcactgccc tcactgttgc agttccttca ttctgttgag   1680

ggcactgcca gcgcggaacc actcaatctg cgtctcgttg aaggtgtggt tcaggaggat   1740

ggtctcctgg gtcccgttgg ggtgcttgat gatgcacttc aggggctgca aggagaaggt   1800

gggtgtgggt ggaagtggtg ggtactgtgt gcccttggcc ccgcaggggg gtcagggaga   1860

cagggcactg cctggggacc taagaggtca gcaggcaaac caaatcctag gccagtctgt   1920

gcctgatggc ccaggtcaga cccaggtggc acctacaggg gattcctggg gcccagaggg   1980

tcctgcagtg ggtgggctgt cccctgagtg ccaggtcctg gtgagtaaag ggaggttggg   2040

gaggtgtgag ggccccgggt tgactccaac ccccaactct gagaagccac tttgctttct   2100

ctgtggggcc acctggagaa ctgggggcct ttccagctgg aatgaagcct cctgggagaa   2160

gctaccctgg ggccagtgca ggaggggaaa caaggtggct gcccctcacc ccaccacctc   2220

agggggaccc gggcccctaa ccttgccagg ggtgaagtcc ttcaggccct gaatggtcag   2280

cttgtccaca gggtgaatct tgttgtagtc agccgggtca gcgaaggtca gaggcagcag   2340

gccctgtttc ttcaggttgg tctctggaaa gcaggcggca ttcggtcatc gggggcctga   2400

ctagcctgga gagcttcatt ttctgaaccc atctggggct ctgggagatg cccctaatcc   2460

tgctgcctgg gacaatgccc gggcagtgac tatggggccc tggtctgctc cctttcacta   2520

ggggtgcccc tagcaagtgt gcgctggtgc tgaggtctgc gaggccttcc tgctgcacat   2580

tcatgatcag aaagaacccc ctggcacatg tcctagatct cagcggctca gatctacaag   2640

cctggaagca gggcctgcgg gaagccggga agctgagcgt cggatgtgca ctgtgtgagc   2700

ctaagaaggg gcaagaggct gacgggcctg tgggctgcag tggacacagc ctagaaccag   2760

gcccaactca gccacgggca gggagagtga ccttgatcac tagggatggg atgaggatgg   2820

cctgggtaca gactccagct caccgtggat cctggcaaag ctcttggtga tgatggcccg   2880

gcccccaagg tggcgaggct ccagagctgc atgctcccgg ctcgagccct cgccgtagtt   2940

ctcgtctccg atcaccaccc acctgatgcc atgtttctgt caggcaagcg ggggtaaggt   3000

tataaggcag aggagggcac cgtcctcacc tgtctggccc tacctgcctg gcctcaccca   3060

cctggcgcct gggcatcctg aggctcccgg taaaggggct ggaggggccc ttcctcgcct   3120

gctgcctaag ggcaagtgaa gcctgcgtga atgagaccca aacgaggccc cgaggggaca   3180

gaggcacgtg gttgtttgca gtggcaaaga agacagaagc cacccattgg tgcttggcag   3240

aggcaggtgt gtgtggaggg aggttgggtg agacagggac ggcctccggg ccccacacaa   3300

gatgcatctg tgaagctcaa ggcgccccct tcctgggagc accctctgcc ccacccagcc   3360

accagggggt gccagagtcc tttcacccgg ctgggccagg acttgggttc agccctggtt   3420

ctgtttgttt ctcaaagcag aaaaagtcca atcacctcag accctctctg cctgctcact   3480

gtgaggcccc gtgtagcccc ctctctgagc ttttggcctc tgacttcctg agtcggcccc   3540

cttccttgtc tttgtctagg gccagatatc ctaagatatc tctcactaac tcctcctggt   3600

gcagggaccc ggctgtacca ccggacctgg gcctcatgcc ttctcagcca cagggagggg   3660

ctgcaggcct ctcctccctt ccacagcagt cccctttggg cttggtcggc ctccttccca   3720

gtttccactc ccctaatgtc ctccctgcac ctgccttgca ggccccttca ggagtgacca   3780

ctggcattgc ccctatcaac tctgacccac cttgtagtag cgggcagtgt cagggacggg   3840

gccaaactcc tgagtgacgg cattgcgcac ggagttggcc ttgccgtttt caatgttgat   3900

ggcaccaatg agcaggttgt tggagatgtt atccaagtgc ccacggaact tgagccaggg   3960

gccagcagct gagatgtggt cagtggtaca cttccctttg accttgggtg gtaagtagag   4020

aggacagagg tcagggcatg gccctggagg ggtggatgac aagccctcca gaggcaggca   4080

gcaggccccg gggcccagga ggggtgacag aggggtgaga ggcaggcaag tcttcagaca   4140

cgtgttctgt ggtcctggtg cttccaccct aaggccacat gggctcaggc caggccttca   4200

tcccctcaaa ggcctctggc tgctcagtct cccttatggg gcagaggccg cccaaagttg   4260

ggacaggtca atgttcgctc acccttcagg cctcagctgc aagatcagcc acagacctca   4320

tgctggacac aggagcccag gacatgcctg ggtcctggct gatgactgat tagtctcttc   4380

tgtcacaggg gtgcctggag accccttaat aagcagcata aataaatatc tgacacagat   4440

tggaggcctc tggccacacc aaaaa                                         4465


<210>  4057
<211>  204
<212>  PRT
<213>  Homosapiens

<400>  4057

Met Phe Val Leu Val Glu Met Val Asp Thr Val Arg Ile Pro Pro Trp 
1               5                   10                  15      


Gln Phe Glu Arg Lys Leu Asn Asp Ser Ile Ala Glu Glu Leu Asn Lys 
            20                  25                  30          


Lys Leu Ala Asn Lys Val Val Tyr Asn Val Gly Leu Cys Ile Cys Leu 
        35                  40                  45              


Phe Asp Ile Thr Lys Leu Glu Asp Ala Tyr Val Phe Pro Gly Asp Gly 
    50                  55                  60                  


Ala Ser His Thr Lys Val His Phe Arg Cys Val Val Phe His Pro Phe 
65                  70                  75                  80  


Leu Asp Glu Ile Leu Ile Gly Lys Ile Lys Gly Cys Ser Pro Glu Gly 
                85                  90                  95      


Val His Val Ser Leu Gly Phe Phe Asp Asp Ile Leu Ile Pro Pro Glu 
            100                 105                 110         


Ser Leu Gln Gln Pro Ala Lys Phe Asp Glu Ala Glu Gln Val Trp Val 
        115                 120                 125             


Trp Glu Tyr Glu Thr Glu Glu Gly Ala His Asp Leu Tyr Met Asp Thr 
    130                 135                 140                 


Gly Glu Glu Ile Arg Phe Arg Val Val Asp Glu Ser Phe Val Asp Thr 
145                 150                 155                 160 


Ser Pro Thr Gly Pro Ser Ser Ala Asp Ala Thr Thr Ser Ser Glu Glu 
                165                 170                 175     


Leu Pro Lys Lys Glu Ala Pro Tyr Thr Leu Val Gly Ser Ile Ser Glu 
            180                 185                 190         


Pro Gly Leu Gly Leu Leu Ser Trp Trp Thr Ser Asn 
        195                 200                 


<210>  4058
<211>  4520
<212>  DNA
<213>  Homosapiens

<400>  4058
gggcaaagcg cgagcggctg tgcgcggtgc gtggtgcgtg gtgcgtgata cgagcggcgg     60

cacgtggcgc gggtgcgggg cgtggagtgg cgtggcgtgg agtggcgtgg cgtggcgggg    120

tctcgcggcg cgggcgcgca cccggagctg tggacggaga gtgcctccct ctggcctcag    180

tttcctcatg ttgtagtagc ggagcatggc ccggaccggg cccccgagac cgccccgtgc    240

aacctcaccg ccagcctggg ggcctcagcg actgggacgg gaccaagggg ctcggggatt    300

ctccctgccc ccggccctgg tgcgtgactg accctcctgt tcccagagcc cccagcgcag    360

gccgggatgt tcgtcctggt ggaaatggtg gacaccgtcc ggatcccccc ttggcagttt    420

gagaggaagc tcaacgactc cattgccgag gagctgaaca agaagttggc caacaaggtc    480

gtgtacaacg tgggactctg catttgtctg tttgatatca ccaaactgga ggatgcctat    540

gtattccctg gggatggcgc atcacacacc aaagtccatt ttcgctgcgt ggtgtttcat    600

ccattcctag atgagattct cattgggaag atcaaaggct gcagcccaga aggagtgcac    660

ggtaacagtg gccctgacgc ctcagacaag acttgggaac actgtggggg caggagtctc    720

tctaggcttc ttcgatgaca ttctcatccc cccagagtca ctgcagcagc cagccaagtt    780

cgacgaagcg gagcaggtgt gggtgtggga gtacgagacg gaggaaggag cacacgacct    840

ctacatggac accggcgagg agatccgctt ccgggtggtg gacgagagct ttgttgacac    900

gtcccccaca gggcccagct cagcagatgc caccacttcc agtgaggagc tgccaaagaa    960

ggaggctccg tacacgcttg tgggatccat cagtgagcca ggcctgggcc ttctctcctg   1020

gtggaccagc aactagccct ggggctggac agtggaccct accagcctgc gggaaggtgg   1080

tatggccggc tgtgaagaca acagcagctg aggccgatgc taaggagata gtgtctcgag   1140

ctggacagtg aggcaaggcc aggagtgccc accagcttgc cccgctcctc caccatctag   1200

gccctgctcc tccttcactg cagtgatgga tccatctgtg gctgtggctg ttgggcctcc   1260

actgaccttg actgaaaaga cccttcctgg accctggact tgacaacaaa cggcacagac   1320

accaatcact cacagaacag tcactggttt tggattcttg ttttccttgc aagaacaaaa   1380

ggttctctag aatccttcag ccaccaatga aatgatcagg caggagaaaa actttagatg   1440

ggagtcttgt catcaaaaat aaatacagtt gcatggagct gcttaagatc tgaaccaaac   1500

tcaaaatagg aagacggggg ctaaaaagtt attttaagaa cccccccacc acaaccacag   1560

tcactccgtg ggctaagcgg ggagcaggaa gcatgtctgg tcacaccatc ttggaatagg   1620

aagccatggc tggacggatc ggatccactg atggcacacg tggagctgaa cttgacgcca   1680

gcggcggggc ggggaggcac tgccctcact gttgcagttc cttcattctg ttgagggcac   1740

tgccagcgcg gaaccactca atctgcgtct cgttgaaggt gtggttcagg aggatggtct   1800

cctgggtccc gttggggtgc ttgatgatgc acttcagggg ctgcaaggag aaggtgggtg   1860

tgggtggaag tggtgggtac tgtgtgccct tggccccgca ggggggtcag ggagacaggg   1920

cactgcctgg ggacctaaga ggtcagcagg caaaccaaat cctaggccag tctgtgcctg   1980

atggcccagg tcagacccag gtggcaccta caggggattc ctggggccca gagggtcctg   2040

cagtgggtgg gctgtcccct gagtgccagg tcctggtgag taaagggagg ttggggaggt   2100

gtgagggccc cgggttgact ccaaccccca actctgagaa gccactttgc tttctctgtg   2160

gggccacctg gagaactggg ggcctttcca gctggaatga agcctcctgg gagaagctac   2220

cctggggcca gtgcaggagg ggaaacaagg tggctgcccc tcaccccacc acctcagggg   2280

gacccgggcc cctaaccttg ccaggggtga agtccttcag gccctgaatg gtcagcttgt   2340

ccacagggtg aatcttgttg tagtcagccg ggtcagcgaa ggtcagaggc agcaggccct   2400

gtttcttcag gttggtctct ggaaagcagg cggcattcgg tcatcggggg cctgactagc   2460

ctggagagct tcattttctg aacccatctg gggctctggg agatgcccct aatcctgctg   2520

cctgggacaa tgcccgggca gtgactatgg ggccctggtc tgctcccttt cactaggggt   2580

gcccctagca agtgtgcgct ggtgctgagg tctgcgaggc cttcctgctg cacattcatg   2640

atcagaaaga accccctggc acatgtccta gatctcagcg gctcagatct acaagcctgg   2700

aagcagggcc tgcgggaagc cgggaagctg agcgtcggat gtgcactgtg tgagcctaag   2760

aaggggcaag aggctgacgg gcctgtgggc tgcagtggac acagcctaga accaggccca   2820

actcagccac gggcagggag agtgaccttg atcactaggg atgggatgag gatggcctgg   2880

gtacagactc cagctcaccg tggatcctgg caaagctctt ggtgatgatg gcccggcccc   2940

caaggtggcg aggctccaga gctgcatgct cccggctcga gccctcgccg tagttctcgt   3000

ctccgatcac cacccacctg atgccatgtt tctgtcaggc aagcgggggt aaggttataa   3060

ggcagaggag ggcaccgtcc tcacctgtct ggccctacct gcctggcctc acccacctgg   3120

cgcctgggca tcctgaggct cccggtaaag gggctggagg ggcccttcct cgcctgctgc   3180

ctaagggcaa gtgaagcctg cgtgaatgag acccaaacga ggccccgagg ggacagaggc   3240

acgtggttgt ttgcagtggc aaagaagaca gaagccaccc attggtgctt ggcagaggca   3300

ggtgtgtgtg gagggaggtt gggtgagaca gggacggcct ccgggcccca cacaagatgc   3360

atctgtgaag ctcaaggcgc ccccttcctg ggagcaccct ctgccccacc cagccaccag   3420

ggggtgccag agtcctttca cccggctggg ccaggacttg ggttcagccc tggttctgtt   3480

tgtttctcaa agcagaaaaa gtccaatcac ctcagaccct ctctgcctgc tcactgtgag   3540

gccccgtgta gccccctctc tgagcttttg gcctctgact tcctgagtcg gcccccttcc   3600

ttgtctttgt ctagggccag atatcctaag atatctctca ctaactcctc ctggtgcagg   3660

gacccggctg taccaccgga cctgggcctc atgccttctc agccacaggg aggggctgca   3720

ggcctctcct cccttccaca gcagtcccct ttgggcttgg tcggcctcct tcccagtttc   3780

cactccccta atgtcctccc tgcacctgcc ttgcaggccc cttcaggagt gaccactggc   3840

attgccccta tcaactctga cccaccttgt agtagcgggc agtgtcaggg acggggccaa   3900

actcctgagt gacggcattg cgcacggagt tggccttgcc gttttcaatg ttgatggcac   3960

caatgagcag gttgttggag atgttatcca agtgcccacg gaacttgagc caggggccag   4020

cagctgagat gtggtcagtg gtacacttcc ctttgacctt gggtggtaag tagagaggac   4080

agaggtcagg gcatggccct ggaggggtgg atgacaagcc ctccagaggc aggcagcagg   4140

ccccggggcc caggaggggt gacagagggg tgagaggcag gcaagtcttc agacacgtgt   4200

tctgtggtcc tggtgcttcc accctaaggc cacatgggct caggccaggc cttcatcccc   4260

tcaaaggcct ctggctgctc agtctccctt atggggcaga ggccgcccaa agttgggaca   4320

ggtcaatgtt cgctcaccct tcaggcctca gctgcaagat cagccacaga cctcatgctg   4380

gacacaggag cccaggacat gcctgggtcc tggctgatga ctgattagtc tcttctgtca   4440

caggggtgcc tggagacccc ttaataagca gcataaataa atatctgaca cagattggag   4500

gcctctggcc acaccaaaaa                                               4520


<210>  4059
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  4059

Met Phe Val Leu Val Glu Met Val Asp Thr Val Arg Ile Pro Pro Trp 
1               5                   10                  15      


Gln Phe Glu Arg Lys Leu Asn Asp Ser Ile Ala Glu Glu Leu Asn Lys 
            20                  25                  30          


Lys Leu Ala Asn Lys Val Val Tyr Asn Val Gly Leu Cys Ile Cys Leu 
        35                  40                  45              


Phe Asp Ile Thr Lys Leu Glu Asp Ala Tyr Val Phe Pro Gly Asp Gly 
    50                  55                  60                  


Ala Ser His Thr Lys Val His Phe Arg Cys Val Val Phe His Pro Phe 
65                  70                  75                  80  


Leu Asp Glu Ile Leu Ile Gly Lys Ile Lys Gly Cys Ser Pro Glu Gly 
                85                  90                  95      


Val His Gly Asn Ser Gly Pro Asp Ala Ser Asp Lys Thr Trp Glu His 
            100                 105                 110         


Cys Gly Gly Arg Ser Leu Ser Arg Leu Leu Arg 
        115                 120             


<210>  4060
<211>  4378
<212>  DNA
<213>  Homosapiens

<400>  4060
gggcaaagcg cgagcggctg tgcgcggtgc gtggtgcgtg gtgcgtgata cgagcggcgg     60

cacgtggcgc gggtgcgggg cgtggagtgg cgtggcgtgg agtggcgtgg cgtggcgggg    120

tctcgcggcg cgggcgcgca cccggagctg tggacggaga gtgcctccct ctggcctcag    180

tttcctcatg ttgtagtagc ggagcatggc ccggaccggg cccccgagac cgccccgtgc    240

aacctcaccg ccagcctggg ggcctcagcg actgggacgg gaccaagggg ctcggggatt    300

ctccctgccc ccggccctgg tgcgtgactg accctcctgt tcccagagcc cccagcgcag    360

gccgggatgt tcgtcctggt ggaaatggtg gacaccgtcc ggatcccccc ttggcagttt    420

gagaggaagc tcaacgactc cattgccgag gagctgaaca agaagttggc caacaaggtc    480

gtgtacaacg tgggactctg catttgtctg tttgatatca ccaaactgga ggatgcctat    540

gtattccctg gggatggcgc atcacacacc aaagtctctc taggcttctt cgatgacatt    600

ctcatccccc cagagtcact gcagcagcca gccaagttcg acgaagcgga gcaggtgtgg    660

gtgtgggagt acgagacgga ggaaggagca cacgacctct acatggacac cggcgaggag    720

atccgcttcc gggtggtgga cgagagcttt gttgacacgt cccccacagg gcccagctca    780

gcagatgcca ccacttccag tgaggagctg ccaaagaagg aggctccgta cacgcttgtg    840

ggatccatca gtgagccagg cctgggcctt ctctcctggt ggaccagcaa ctagccctgg    900

ggctggacag tggaccctac cagcctgcgg gaaggtggta tggccggctg tgaagacaac    960

agcagctgag gccgatgcta aggagatagt gtctcgagct ggacagtgag gcaaggccag   1020

gagtgcccac cagcttgccc cgctcctcca ccatctaggc cctgctcctc cttcactgca   1080

gtgatggatc catctgtggc tgtggctgtt gggcctccac tgaccttgac tgaaaagacc   1140

cttcctggac cctggacttg acaacaaacg gcacagacac caatcactca cagaacagtc   1200

actggttttg gattcttgtt ttccttgcaa gaacaaaagg ttctctagaa tccttcagcc   1260

accaatgaaa tgatcaggca ggagaaaaac tttagatggg agtcttgtca tcaaaaataa   1320

atacagttgc atggagctgc ttaagatctg aaccaaactc aaaataggaa gacgggggct   1380

aaaaagttat tttaagaacc cccccaccac aaccacagtc actccgtggg ctaagcgggg   1440

agcaggaagc atgtctggtc acaccatctt ggaataggaa gccatggctg gacggatcgg   1500

atccactgat ggcacacgtg gagctgaact tgacgccagc ggcggggcgg ggaggcactg   1560

ccctcactgt tgcagttcct tcattctgtt gagggcactg ccagcgcgga accactcaat   1620

ctgcgtctcg ttgaaggtgt ggttcaggag gatggtctcc tgggtcccgt tggggtgctt   1680

gatgatgcac ttcaggggct gcaaggagaa ggtgggtgtg ggtggaagtg gtgggtactg   1740

tgtgcccttg gccccgcagg ggggtcaggg agacagggca ctgcctgggg acctaagagg   1800

tcagcaggca aaccaaatcc taggccagtc tgtgcctgat ggcccaggtc agacccaggt   1860

ggcacctaca ggggattcct ggggcccaga gggtcctgca gtgggtgggc tgtcccctga   1920

gtgccaggtc ctggtgagta aagggaggtt ggggaggtgt gagggccccg ggttgactcc   1980

aacccccaac tctgagaagc cactttgctt tctctgtggg gccacctgga gaactggggg   2040

cctttccagc tggaatgaag cctcctggga gaagctaccc tggggccagt gcaggagggg   2100

aaacaaggtg gctgcccctc accccaccac ctcaggggga cccgggcccc taaccttgcc   2160

aggggtgaag tccttcaggc cctgaatggt cagcttgtcc acagggtgaa tcttgttgta   2220

gtcagccggg tcagcgaagg tcagaggcag caggccctgt ttcttcaggt tggtctctgg   2280

aaagcaggcg gcattcggtc atcgggggcc tgactagcct ggagagcttc attttctgaa   2340

cccatctggg gctctgggag atgcccctaa tcctgctgcc tgggacaatg cccgggcagt   2400

gactatgggg ccctggtctg ctccctttca ctaggggtgc ccctagcaag tgtgcgctgg   2460

tgctgaggtc tgcgaggcct tcctgctgca cattcatgat cagaaagaac cccctggcac   2520

atgtcctaga tctcagcggc tcagatctac aagcctggaa gcagggcctg cgggaagccg   2580

ggaagctgag cgtcggatgt gcactgtgtg agcctaagaa ggggcaagag gctgacgggc   2640

ctgtgggctg cagtggacac agcctagaac caggcccaac tcagccacgg gcagggagag   2700

tgaccttgat cactagggat gggatgagga tggcctgggt acagactcca gctcaccgtg   2760

gatcctggca aagctcttgg tgatgatggc ccggccccca aggtggcgag gctccagagc   2820

tgcatgctcc cggctcgagc cctcgccgta gttctcgtct ccgatcacca cccacctgat   2880

gccatgtttc tgtcaggcaa gcgggggtaa ggttataagg cagaggaggg caccgtcctc   2940

acctgtctgg ccctacctgc ctggcctcac ccacctggcg cctgggcatc ctgaggctcc   3000

cggtaaaggg gctggagggg cccttcctcg cctgctgcct aagggcaagt gaagcctgcg   3060

tgaatgagac ccaaacgagg ccccgagggg acagaggcac gtggttgttt gcagtggcaa   3120

agaagacaga agccacccat tggtgcttgg cagaggcagg tgtgtgtgga gggaggttgg   3180

gtgagacagg gacggcctcc gggccccaca caagatgcat ctgtgaagct caaggcgccc   3240

ccttcctggg agcaccctct gccccaccca gccaccaggg ggtgccagag tcctttcacc   3300

cggctgggcc aggacttggg ttcagccctg gttctgtttg tttctcaaag cagaaaaagt   3360

ccaatcacct cagaccctct ctgcctgctc actgtgaggc cccgtgtagc cccctctctg   3420

agcttttggc ctctgacttc ctgagtcggc ccccttcctt gtctttgtct agggccagat   3480

atcctaagat atctctcact aactcctcct ggtgcaggga cccggctgta ccaccggacc   3540

tgggcctcat gccttctcag ccacagggag gggctgcagg cctctcctcc cttccacagc   3600

agtccccttt gggcttggtc ggcctccttc ccagtttcca ctcccctaat gtcctccctg   3660

cacctgcctt gcaggcccct tcaggagtga ccactggcat tgcccctatc aactctgacc   3720

caccttgtag tagcgggcag tgtcagggac ggggccaaac tcctgagtga cggcattgcg   3780

cacggagttg gccttgccgt tttcaatgtt gatggcacca atgagcaggt tgttggagat   3840

gttatccaag tgcccacgga acttgagcca ggggccagca gctgagatgt ggtcagtggt   3900

acacttccct ttgaccttgg gtggtaagta gagaggacag aggtcagggc atggccctgg   3960

aggggtggat gacaagccct ccagaggcag gcagcaggcc ccggggccca ggaggggtga   4020

cagaggggtg agaggcaggc aagtcttcag acacgtgttc tgtggtcctg gtgcttccac   4080

cctaaggcca catgggctca ggccaggcct tcatcccctc aaaggcctct ggctgctcag   4140

tctcccttat ggggcagagg ccgcccaaag ttgggacagg tcaatgttcg ctcacccttc   4200

aggcctcagc tgcaagatca gccacagacc tcatgctgga cacaggagcc caggacatgc   4260

ctgggtcctg gctgatgact gattagtctc ttctgtcaca ggggtgcctg gagacccctt   4320

aataagcagc ataaataaat atctgacaca gattggaggc ctctggccac accaaaaa     4378


<210>  4061
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  4061

Met Phe Val Leu Val Glu Met Val Asp Thr Val Arg Ile Pro Pro Trp 
1               5                   10                  15      


Gln Phe Glu Arg Lys Leu Asn Asp Ser Ile Ala Glu Glu Leu Asn Lys 
            20                  25                  30          


Lys Leu Ala Asn Lys Val Val Tyr Asn Val Gly Leu Cys Ile Cys Leu 
        35                  40                  45              


Phe Asp Ile Thr Lys Leu Glu Asp Ala Tyr Val Phe Pro Gly Asp Gly 
    50                  55                  60                  


Ala Ser His Thr Lys Val Ser Leu Gly Phe Phe Asp Asp Ile Leu Ile 
65                  70                  75                  80  


Pro Pro Glu Ser Leu Gln Gln Pro Ala Lys Phe Asp Glu Ala Glu Gln 
                85                  90                  95      


Val Trp Val Trp Glu Tyr Glu Thr Glu Glu Gly Ala His Asp Leu Tyr 
            100                 105                 110         


Met Asp Thr Gly Glu Glu Ile Arg Phe Arg Val Val Asp Glu Ser Phe 
        115                 120                 125             


Val Asp Thr Ser Pro Thr Gly Pro Ser Ser Ala Asp Ala Thr Thr Ser 
    130                 135                 140                 


Ser Glu Glu Leu Pro Lys Lys Glu Ala Pro Tyr Thr Leu Val Gly Ser 
145                 150                 155                 160 


Ile Ser Glu Pro Gly Leu Gly Leu Leu Ser Trp Trp Thr Ser Asn 
                165                 170                 175 


<210>  4062
<211>  4159
<212>  DNA
<213>  Homosapiens

<400>  4062
gcgcgagcgg ctgtgcgcgg tgcgtggtgc gtggtgcgag agcccccagc gcaggccggg     60

atgttcgtcc tggtggaaat ggtggacacc gtccggatcc ccccttggca gtttgagagg    120

aagctcaacg actccattgc cgaggagctg aacaagaagt tggccaacaa ggtcgtgtac    180

aacgtgggac tctgcatttg tctgtttgat atcaccaaac tggaggatgc ctatgtattc    240

cctggggatg gcgcatcaca caccaaagtc cattttcgct gcgtggtgtt tcatccattc    300

ctagatgaga ttctcattgg gaagatcaaa ggctgcagcc cagaaggagt gcacgtctct    360

ctaggcttct tcgatgacat tctcatcccc ccagagtcac tgcagcagcc agccaagttc    420

gacgaagcgg agcaggtgtg ggtgtgggag tacgagacgg aggaaggagc acacgacctc    480

tacatggaca ccggcgagga gatccgcttc cgggtggtgg acgagagctt tgttgacacg    540

tcccccacag ggcccagctc agcagatgcc accacttcca gtgaggagct gccaaagaag    600

gaggctccgt acacgcttgt gggatccatc agtgagccag gcctgggcct tctctcctgg    660

tggaccagca actagccctg gggctggaca gtggacccta ccagcctgcg ggaaggtggt    720

atggccggct gtgaagacaa cagcagctga ggccgatgct aaggagatag tgtctcgagc    780

tggacagtga ggcaaggcca ggagtgccca ccagcttgcc ccgctcctcc accatctagg    840

ccctgctcct ccttcactgc agtgatggat ccatctgtgg ctgtggctgt tgggcctcca    900

ctgaccttga ctgaaaagac ccttcctgga ccctggactt gacaacaaac ggcacagaca    960

ccaatcactc acagaacagt cactggtttt ggattcttgt tttccttgca agaacaaaag   1020

gttctctaga atccttcagc caccaatgaa atgatcaggc aggagaaaaa ctttagatgg   1080

gagtcttgtc atcaaaaata aatacagttg catggagctg cttaagatct gaaccaaact   1140

caaaatagga agacgggggc taaaaagtta ttttaagaac ccccccacca caaccacagt   1200

cactccgtgg gctaagcggg gagcaggaag catgtctggt cacaccatct tggaatagga   1260

agccatggct ggacggatcg gatccactga tggcacacgt ggagctgaac ttgacgccag   1320

cggcggggcg gggaggcact gccctcactg ttgcagttcc ttcattctgt tgagggcact   1380

gccagcgcgg aaccactcaa tctgcgtctc gttgaaggtg tggttcagga ggatggtctc   1440

ctgggtcccg ttggggtgct tgatgatgca cttcaggggc tgcaaggaga aggtgggtgt   1500

gggtggaagt ggtgggtact gtgtgccctt ggccccgcag gggggtcagg gagacagggc   1560

actgcctggg gacctaagag gtcagcaggc aaaccaaatc ctaggccagt ctgtgcctga   1620

tggcccaggt cagacccagg tggcacctac aggggattcc tggggcccag agggtcctgc   1680

agtgggtggg ctgtcccctg agtgccaggt cctggtgagt aaagggaggt tggggaggtg   1740

tgagggcccc gggttgactc caacccccaa ctctgagaag ccactttgct ttctctgtgg   1800

ggccacctgg agaactgggg gcctttccag ctggaatgaa gcctcctggg agaagctacc   1860

ctggggccag tgcaggaggg gaaacaaggt ggctgcccct caccccacca cctcaggggg   1920

acccgggccc ctaaccttgc caggggtgaa gtccttcagg ccctgaatgg tcagcttgtc   1980

cacagggtga atcttgttgt agtcagccgg gtcagcgaag gtcagaggca gcaggccctg   2040

tttcttcagg ttggtctctg gaaagcaggc ggcattcggt catcgggggc ctgactagcc   2100

tggagagctt cattttctga acccatctgg ggctctggga gatgccccta atcctgctgc   2160

ctgggacaat gcccgggcag tgactatggg gccctggtct gctccctttc actaggggtg   2220

cccctagcaa gtgtgcgctg gtgctgaggt ctgcgaggcc ttcctgctgc acattcatga   2280

tcagaaagaa ccccctggca catgtcctag atctcagcgg ctcagatcta caagcctgga   2340

agcagggcct gcgggaagcc gggaagctga gcgtcggatg tgcactgtgt gagcctaaga   2400

aggggcaaga ggctgacggg cctgtgggct gcagtggaca cagcctagaa ccaggcccaa   2460

ctcagccacg ggcagggaga gtgaccttga tcactaggga tgggatgagg atggcctggg   2520

tacagactcc agctcaccgt ggatcctggc aaagctcttg gtgatgatgg cccggccccc   2580

aaggtggcga ggctccagag ctgcatgctc ccggctcgag ccctcgccgt agttctcgtc   2640

tccgatcacc acccacctga tgccatgttt ctgtcaggca agcgggggta aggttataag   2700

gcagaggagg gcaccgtcct cacctgtctg gccctacctg cctggcctca cccacctggc   2760

gcctgggcat cctgaggctc ccggtaaagg ggctggaggg gcccttcctc gcctgctgcc   2820

taagggcaag tgaagcctgc gtgaatgaga cccaaacgag gccccgaggg gacagaggca   2880

cgtggttgtt tgcagtggca aagaagacag aagccaccca ttggtgcttg gcagaggcag   2940

gtgtgtgtgg agggaggttg ggtgagacag ggacggcctc cgggccccac acaagatgca   3000

tctgtgaagc tcaaggcgcc cccttcctgg gagcaccctc tgccccaccc agccaccagg   3060

gggtgccaga gtcctttcac ccggctgggc caggacttgg gttcagccct ggttctgttt   3120

gtttctcaaa gcagaaaaag tccaatcacc tcagaccctc tctgcctgct cactgtgagg   3180

ccccgtgtag ccccctctct gagcttttgg cctctgactt cctgagtcgg cccccttcct   3240

tgtctttgtc tagggccaga tatcctaaga tatctctcac taactcctcc tggtgcaggg   3300

acccggctgt accaccggac ctgggcctca tgccttctca gccacaggga ggggctgcag   3360

gcctctcctc ccttccacag cagtcccctt tgggcttggt cggcctcctt cccagtttcc   3420

actcccctaa tgtcctccct gcacctgcct tgcaggcccc ttcaggagtg accactggca   3480

ttgcccctat caactctgac ccaccttgta gtagcgggca gtgtcaggga cggggccaaa   3540

ctcctgagtg acggcattgc gcacggagtt ggccttgccg ttttcaatgt tgatggcacc   3600

aatgagcagg ttgttggaga tgttatccaa gtgcccacgg aacttgagcc aggggccagc   3660

agctgagatg tggtcagtgg tacacttccc tttgaccttg ggtggtaagt agagaggaca   3720

gaggtcaggg catggccctg gaggggtgga tgacaagccc tccagaggca ggcagcaggc   3780

cccggggccc aggaggggtg acagaggggt gagaggcagg caagtcttca gacacgtgtt   3840

ctgtggtcct ggtgcttcca ccctaaggcc acatgggctc aggccaggcc ttcatcccct   3900

caaaggcctc tggctgctca gtctccctta tggggcagag gccgcccaaa gttgggacag   3960

gtcaatgttc gctcaccctt caggcctcag ctgcaagatc agccacagac ctcatgctgg   4020

acacaggagc ccaggacatg cctgggtcct ggctgatgac tgattagtct cttctgtcac   4080

aggggtgcct ggagacccct taataagcag cataaataaa tatctgacac agattggagg   4140

cctctggcca caccaaaaa                                                4159


<210>  4063
<211>  204
<212>  PRT
<213>  Homosapiens

<400>  4063

Met Phe Val Leu Val Glu Met Val Asp Thr Val Arg Ile Pro Pro Trp 
1               5                   10                  15      


Gln Phe Glu Arg Lys Leu Asn Asp Ser Ile Ala Glu Glu Leu Asn Lys 
            20                  25                  30          


Lys Leu Ala Asn Lys Val Val Tyr Asn Val Gly Leu Cys Ile Cys Leu 
        35                  40                  45              


Phe Asp Ile Thr Lys Leu Glu Asp Ala Tyr Val Phe Pro Gly Asp Gly 
    50                  55                  60                  


Ala Ser His Thr Lys Val His Phe Arg Cys Val Val Phe His Pro Phe 
65                  70                  75                  80  


Leu Asp Glu Ile Leu Ile Gly Lys Ile Lys Gly Cys Ser Pro Glu Gly 
                85                  90                  95      


Val His Val Ser Leu Gly Phe Phe Asp Asp Ile Leu Ile Pro Pro Glu 
            100                 105                 110         


Ser Leu Gln Gln Pro Ala Lys Phe Asp Glu Ala Glu Gln Val Trp Val 
        115                 120                 125             


Trp Glu Tyr Glu Thr Glu Glu Gly Ala His Asp Leu Tyr Met Asp Thr 
    130                 135                 140                 


Gly Glu Glu Ile Arg Phe Arg Val Val Asp Glu Ser Phe Val Asp Thr 
145                 150                 155                 160 


Ser Pro Thr Gly Pro Ser Ser Ala Asp Ala Thr Thr Ser Ser Glu Glu 
                165                 170                 175     


Leu Pro Lys Lys Glu Ala Pro Tyr Thr Leu Val Gly Ser Ile Ser Glu 
            180                 185                 190         


Pro Gly Leu Gly Leu Leu Ser Trp Trp Thr Ser Asn 
        195                 200                 


<210>  4064
<211>  2380
<212>  DNA
<213>  Homosapiens

<400>  4064
cacacacaca cacacacaat cttccagacc catcccctgc ctgccagctc cacgagccag     60

agagagacag agcgcggacg ccgcaggagg cagtgcctgg accccagctg cccaggagag    120

acggagcccg tggctggtga ggccgcagag cagggccagg ccgggccctg cccgcaagga    180

cgaccaaacc cctcaccggc ccctgggccc cagagcccac caggctctcc tgctggcccc    240

accatgactt cagagtcgac gtcaccccca gttgtgcccc cgctccactc ccccaagtcc    300

ccagtctggc ccaccttccc cttccacagg gagggcagca gggtctggga gcggggtggt    360

gtcccacctc gggacctacc cagccctctg cccaccaagc ggaccaggac ctattcagcg    420

acagcccggg cctcagctgg ccccgtgttc aagggcgtct gtaagcagtt ctcacgctca    480

cagggccatg gcttcatcac ccccgagaac gggtccgagg acatcttcgt acatgtgtct    540

gacatcgagg gggagtacgt gccagtggag ggcgacgagg tgacctacaa gatgtgccct    600

atccctccca agaaccagaa gttccaggcc gtggaggtgg tgctcactca gctggccccc    660

cacactcccc acgagacgtg gtctggccag gtcgtgggct cctaggctga gtggttcaca    720

ggccagctgg ccgggggttg gggagccaca cagggtgaac gggcagcagc cggctccatg    780

ccccactgcc ctggctgatg agtccttcgg tggcctcagt gtgcacgtct gtctgtccgt    840

ctgtgcttgt ggctatgagc gtgtgcctcc acccacccca cgacccgtga ctactgtgca    900

agctggccag gaggtaggtg gagggcaagg ccaccagacc tggcttcgcg ctgtccactg    960

cctctctcct cccctccctg ccgcagacac gcaggacccg ctcgccctcc tgcttacccg   1020

tccccacggt gactgagctg cgagagcctg cgctgggctc actccctggc ctccgcccct   1080

gagctgtccc gtgtcagtcc ctggcccgga gccaggctct ctgtgctact tacatctccc   1140

tcccttggct gaggtccccc gccacagcct ggacccttcc ctcagaagcc tggccgatgg   1200

gtgcttttgg ggagcctctc agcctggcag tggcgctggg ctccttcccc tgggctgtac   1260

tgagccgagc ccaggggttt gcagagggtg ggggtccatc tctccagctt ggctgcagac   1320

ctcctttacc ctgactcaca agccccactg atgctctggg ccatgcccgg ctgacggctg   1380

ctgtggatgc cgcgagggac ggacacacgt ccggggcacc cacgaggagg gcccccagcc   1440

tgggagactg gccctgcggc ctccacgtca aactctcttc ccaaagccct aacagaccag   1500

tggccgaggt gtggctctta ttgcatccat ccctgaagat gtgtggctgt tgctgtcacc   1560

tggagtcctt ttggggccaa gatgtgtgtg cacccggggt cgtggccatt cactcccagg   1620

caggggtgag ggtggcctgg cccaggaggc caggaaggag ggccctgtct gcctccacct   1680

ctgggtgcac cccctgccta ccaccctccc ttctagagag cacatcgcct gaccggggag   1740

aagtggggcc gtggttcgag ggagggctgg ccaggggtgg gacccttatg agactcagtc   1800

tgtgagtaaa actgggggct caaatgccca ggatgagggg atcagtgact gtctaggagg   1860

atcccttgcc ttgtaggtgc cccaagaccg cagggtagaa atcagccggg atgcctgcat   1920

cccacccccg gccccagggc ccaccacata aaatctggga gcccagagct gctgaggtgt   1980

ggtcagctcc cctaaaatgg gcacggccca gcctgtccca tgaggaataa aggcccctgg   2040

cccccttgag agagggcttg ttggtgaggg ctgactcctg ggggccccca aggctcccct   2100

cctgtgggga ggccaccttt taaggcacca ctagcagtca ggatatggtg gcatcagccc   2160

tggggcctcc tgggtggcag gggggcagca gctctcctcc ccactcacag gccctgcagt   2220

gctcatttgg aattcctccc aagacccctg gccacccaga ccccccattc ttcctaacac   2280

tggcaataaa ccctcaactg tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2340

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                         2380


<210>  4065
<211>  153
<212>  PRT
<213>  Homosapiens

<400>  4065

Met Thr Ser Glu Ser Thr Ser Pro Pro Val Val Pro Pro Leu His Ser 
1               5                   10                  15      


Pro Lys Ser Pro Val Trp Pro Thr Phe Pro Phe His Arg Glu Gly Ser 
            20                  25                  30          


Arg Val Trp Glu Arg Gly Gly Val Pro Pro Arg Asp Leu Pro Ser Pro 
        35                  40                  45              


Leu Pro Thr Lys Arg Thr Arg Thr Tyr Ser Ala Thr Ala Arg Ala Ser 
    50                  55                  60                  


Ala Gly Pro Val Phe Lys Gly Val Cys Lys Gln Phe Ser Arg Ser Gln 
65                  70                  75                  80  


Gly His Gly Phe Ile Thr Pro Glu Asn Gly Ser Glu Asp Ile Phe Val 
                85                  90                  95      


His Val Ser Asp Ile Glu Gly Glu Tyr Val Pro Val Glu Gly Asp Glu 
            100                 105                 110         


Val Thr Tyr Lys Met Cys Pro Ile Pro Pro Lys Asn Gln Lys Phe Gln 
        115                 120                 125             


Ala Val Glu Val Val Leu Thr Gln Leu Ala Pro His Thr Pro His Glu 
    130                 135                 140                 


Thr Trp Ser Gly Gln Val Val Gly Ser 
145                 150             


<210>  4066
<211>  1210
<212>  DNA
<213>  Homosapiens

<400>  4066
agccatggca gtcaccgccc aggcagcccg cagaagggag cgcgtcctct gcctgtttga     60

cgtggacggg accctcacgc cggctcgcca gaaaattgac cctgaggtgg ccgccttcct    120

gcagaagcta cgaagtagag tgcagatcgg tgtggtgggc ggctctgact actgtaagat    180

cgctgagcag ctgggtgacg gggatgaagt cattgagaag tttgattatg tgtttgccga    240

gaacgggacg gtgcagtata agcacggacg actgctctcc aagcagacca tccagaacca    300

cctgggggag gagctgctgc aggacttgat caacttctgc ctcagctaca tggccctgct    360

caggctgccc aagaagcgtg gaaccttcat cgagttccgg aatggcatgc tgaacatctc    420

gcccatcggc cggagctgca ccctggagga gaggatcgag ttctccgaac tggacaagaa    480

agagaagatc cgggagaagt tcgtggaaga cctgaaaaca gagtttgctg gcaaagggct    540

gaggttctct cgaggaggca tgatcagctt tgacgtcttc cccgagggct gggacaagcg    600

ctactgcctg gatagcctgg accaggacag cttcgacacc atccacttct ttgggaacga    660

gactagccct ggtgggaacg actttgagat ctttgccgac ccccggactg ttggccacag    720

cgtggtgtct cctcaggaca cggtgcagcg atgccgggag attttcttcc cagagacagc    780

tcatgaggcg tgaccggggc ccacatctgt gtgtcgtgac ttctgaagag tttggcctag    840

gcctaaagag aggtcctggt gttggataga tgccagggcc cctcctctgg cccaggacgc    900

ctgctgcaag cccacccaga tggggccaga gtctgtgtgg acaaccgtcc ccagccagtc    960

tgctcctagt ggcactggct tcgtcctccc agggcccaga gtgttcccca tgctccacct   1020

ggtgccccag gccacagctg ctgcttgtat ttcggtacag aagaggtttc tttctgcacc   1080

aggaggaggc gtgctcaagt atcggtacga gatctagcct gccctgcctg cctgccctgg   1140

gcgatgaggt acggtgggga aggtgcctat tttagagaac tttgtcacag tattaaagtt   1200

ccctcgtgcc                                                          1210


<210>  4067
<211>  262
<212>  PRT
<213>  Homosapiens

<400>  4067

Met Ala Val Thr Ala Gln Ala Ala Arg Arg Arg Glu Arg Val Leu Cys 
1               5                   10                  15      


Leu Phe Asp Val Asp Gly Thr Leu Thr Pro Ala Arg Gln Lys Ile Asp 
            20                  25                  30          


Pro Glu Val Ala Ala Phe Leu Gln Lys Leu Arg Ser Arg Val Gln Ile 
        35                  40                  45              


Gly Val Val Gly Gly Ser Asp Tyr Cys Lys Ile Ala Glu Gln Leu Gly 
    50                  55                  60                  


Asp Gly Asp Glu Val Ile Glu Lys Phe Asp Tyr Val Phe Ala Glu Asn 
65                  70                  75                  80  


Gly Thr Val Gln Tyr Lys His Gly Arg Leu Leu Ser Lys Gln Thr Ile 
                85                  90                  95      


Gln Asn His Leu Gly Glu Glu Leu Leu Gln Asp Leu Ile Asn Phe Cys 
            100                 105                 110         


Leu Ser Tyr Met Ala Leu Leu Arg Leu Pro Lys Lys Arg Gly Thr Phe 
        115                 120                 125             


Ile Glu Phe Arg Asn Gly Met Leu Asn Ile Ser Pro Ile Gly Arg Ser 
    130                 135                 140                 


Cys Thr Leu Glu Glu Arg Ile Glu Phe Ser Glu Leu Asp Lys Lys Glu 
145                 150                 155                 160 


Lys Ile Arg Glu Lys Phe Val Glu Asp Leu Lys Thr Glu Phe Ala Gly 
                165                 170                 175     


Lys Gly Leu Arg Phe Ser Arg Gly Gly Met Ile Ser Phe Asp Val Phe 
            180                 185                 190         


Pro Glu Gly Trp Asp Lys Arg Tyr Cys Leu Asp Ser Leu Asp Gln Asp 
        195                 200                 205             


Ser Phe Asp Thr Ile His Phe Phe Gly Asn Glu Thr Ser Pro Gly Gly 
    210                 215                 220                 


Asn Asp Phe Glu Ile Phe Ala Asp Pro Arg Thr Val Gly His Ser Val 
225                 230                 235                 240 


Val Ser Pro Gln Asp Thr Val Gln Arg Cys Arg Glu Ile Phe Phe Pro 
                245                 250                 255     


Glu Thr Ala His Glu Ala 
            260         


<210>  4068
<211>  745
<212>  DNA
<213>  Homosapiens

<400>  4068
gtcgggtacg ggaaggtcca agccgctgcc gggtgcccga gggccgtcgt ggccgccgtc     60

gccacgggtc ccaatggagc cgccgaatct ctatccggtg aagctctacg tgtacgacct    120

gtccaaaggc ctggcccggc ggctcagccc catcatgctg gggaaacaac tggaaggcat    180

ctggcacaca tccatagttg tgcacaagga tgagttcttc ttcggcagtg gtggtatctc    240

cagctgcccc ccgggaggga cattgcttgg gcctccagac tctgtggttg atgtggggag    300

tacagaagtc acagaagaaa tctttctgga gtacctctcc tccctggggg agtccctgtt    360

ccgaggtgag gcctacaacc tctttgaaca caattgtaac accttcagca acgaagtggc    420

acagttcctg actgggcgga agattccttc ttacatcaca gacctgccct ctgaagttct    480

ctccacgccc tttggacagg cacttcggcc cctcctggac tccattcaga tccagcctcc    540

aggagggagc tccgtgggca gacccaacgg ccagagctaa caggactgcc tgggaccgcc    600

ctgcctcacc agggcttttc ctttttaaac aaaacaaacc ctaccagatt tctattttat    660

aattttacat cagagctaac aaccagggga cggcttttta aatttcccag ggaaggagac    720

cgtcaggccg catgtagaca atgct                                          745


<210>  4069
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  4069

Met Glu Pro Pro Asn Leu Tyr Pro Val Lys Leu Tyr Val Tyr Asp Leu 
1               5                   10                  15      


Ser Lys Gly Leu Ala Arg Arg Leu Ser Pro Ile Met Leu Gly Lys Gln 
            20                  25                  30          


Leu Glu Gly Ile Trp His Thr Ser Ile Val Val His Lys Asp Glu Phe 
        35                  40                  45              


Phe Phe Gly Ser Gly Gly Ile Ser Ser Cys Pro Pro Gly Gly Thr Leu 
    50                  55                  60                  


Leu Gly Pro Pro Asp Ser Val Val Asp Val Gly Ser Thr Glu Val Thr 
65                  70                  75                  80  


Glu Glu Ile Phe Leu Glu Tyr Leu Ser Ser Leu Gly Glu Ser Leu Phe 
                85                  90                  95      


Arg Gly Glu Ala Tyr Asn Leu Phe Glu His Asn Cys Asn Thr Phe Ser 
            100                 105                 110         


Asn Glu Val Ala Gln Phe Leu Thr Gly Arg Lys Ile Pro Ser Tyr Ile 
        115                 120                 125             


Thr Asp Leu Pro Ser Glu Val Leu Ser Thr Pro Phe Gly Gln Ala Leu 
    130                 135                 140                 


Arg Pro Leu Leu Asp Ser Ile Gln Ile Gln Pro Pro Gly Gly Ser Ser 
145                 150                 155                 160 


Val Gly Arg Pro Asn Gly Gln Ser 
                165             


<210>  4070
<211>  2156
<212>  DNA
<213>  Homosapiens

<400>  4070
gcgcatgcgt ggattgtcgt cttctgtcca agttggtcgc ttccctgcgc caaagtgagc     60

agtagccaac atgtcagggt gggagtcata ttacaaaacc gagggcgatg aagaagcaga    120

ggaagaacaa gaagagaacc ttgaagcaag tggagactat aaatattcag gaagagatag    180

tttgattttt ttggttgatg cctccaaggc tatgtttgaa tctcagagtg aagatgagtt    240

gacacctttt gacatgagca tccagtgtat ccaaagtgtg tacatcagta agatcataag    300

cagtgatcga gatctcttgg ctgtggtgtt ctatggtacc gagaaagaca aaaattcagt    360

gaattttaaa aatatttacg tcttacagga gctggataat ccaggtgcaa aacgaattct    420

agagcttgac cagtttaagg ggcagcaggg acaaaaacgt ttccaagaca tgatgggcca    480

cggatctgac tactcactca gtgaagtgct gtgggtctgt gccaacctct ttagtgatgt    540

ccaattcaag atgagtcata agaggatcat gctgttcacc aatgaagaca acccccatgg    600

caatgacagt gccaaagcca gccgggccag gaccaaagcc ggtgatctcc gagatacagg    660

catcttcctt gacttgatgc acctgaagaa acctgggggc tttgacatat ccttgttcta    720

cagagatatc atcagcatag cagaggatga ggacctcagg gttcactttg aggaatccag    780

caagctagaa gacctgttgc ggaaggttcg cgccaaggag accaggaagc gagcactcag    840

caggttaaag ctgaagctca acaaagatat agtgatctct gtgggcattt ataatctggt    900

ccagaaggct ctcaagcctc ctccaataaa gctctatcgg gaaacaaatg aaccagtgaa    960

aaccaagacc cggaccttta atacaagtac aggcggtttg cttctgccta gcgataccaa   1020

gaggtctcag atctatggga gtcgtcagat tatactggag aaagaggaaa cagaagagct   1080

aaaacggttt gatgatccag gtttgatgct catgggtttc aagccgttgg tactgctgaa   1140

gaaacaccat tacctgaggc cctccctgtt cgtgtaccca gaggagtcgc tggtgattgg   1200

gagctcaacc ctgttcagtg ctctgctcat caagtgtctg gagaaggagg ttgcagcatt   1260

gtgcagatac acaccccgca ggaacatccc tccttatttt gtggctttgg tgccacagga   1320

agaagagttg gatgaccaga aaattcaggt gactcctcca ggcttccagc tggtcttttt   1380

accctttgct gatgataaaa ggaagatgcc ctttactgaa aaaatcatgg caactccaga   1440

gcaggtgggc aagatgaagg ctatcgttga gaagcttcgc ttcacataca gaagtgacag   1500

ctttgagaac cccgtgctgc agcagcactt caggaacctg gaggccttgg ccttggattt   1560

gatggagccg gaacaagcag tggacctgac attgcccaag gttgaagcaa tgaataaaag   1620

actgggctcc ttggtggatg agtttaagga gcttgtttac ccaccagatt acaatcctga   1680

agggaaagtt accaagagaa aacacgataa tgaaggttct ggaagcaaaa ggcccaaggt   1740

ggagtattca gaagaggagc tgaagaccca catcagcaag ggtacgctgg gcaagttcac   1800

tgtgcccatg ctgaaagagg cctgccgggc ttacgggctg aagagtgggc tgaagaagca   1860

ggagctgctg gaagccctca ccaagcactt ccaggactga ccagaggccg cgcgtccagc   1920

tgcccttccg cagtgtggcc aggctgcctg gccttgtcct cagccagtta aaatgtgttt   1980

ctcctgagct aggaagagtc tacccgacat aagtcgaggg actttatgtt tttgaggctt   2040

tctgttgcca tggtgatggt gtagccctcc cactttgctg ttccttactt tactgcctga   2100

ataaagagcc ctaagtttgt actatatact gttaaaaaaa aaaaaaaaaa aaaaaa       2156


<210>  4071
<211>  609
<212>  PRT
<213>  Homosapiens

<400>  4071

Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Asp Glu Glu Ala 
1               5                   10                  15      


Glu Glu Glu Gln Glu Glu Asn Leu Glu Ala Ser Gly Asp Tyr Lys Tyr 
            20                  25                  30          


Ser Gly Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Lys Ala Met 
        35                  40                  45              


Phe Glu Ser Gln Ser Glu Asp Glu Leu Thr Pro Phe Asp Met Ser Ile 
    50                  55                  60                  


Gln Cys Ile Gln Ser Val Tyr Ile Ser Lys Ile Ile Ser Ser Asp Arg 
65                  70                  75                  80  


Asp Leu Leu Ala Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser 
                85                  90                  95      


Val Asn Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly 
            100                 105                 110         


Ala Lys Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln 
        115                 120                 125             


Lys Arg Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser 
    130                 135                 140                 


Glu Val Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Phe Lys 
145                 150                 155                 160 


Met Ser His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asn Pro His 
                165                 170                 175     


Gly Asn Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Gly Asp 
            180                 185                 190         


Leu Arg Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Lys Pro 
        195                 200                 205             


Gly Gly Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala 
    210                 215                 220                 


Glu Asp Glu Asp Leu Arg Val His Phe Glu Glu Ser Ser Lys Leu Glu 
225                 230                 235                 240 


Asp Leu Leu Arg Lys Val Arg Ala Lys Glu Thr Arg Lys Arg Ala Leu 
                245                 250                 255     


Ser Arg Leu Lys Leu Lys Leu Asn Lys Asp Ile Val Ile Ser Val Gly 
            260                 265                 270         


Ile Tyr Asn Leu Val Gln Lys Ala Leu Lys Pro Pro Pro Ile Lys Leu 
        275                 280                 285             


Tyr Arg Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn 
    290                 295                 300                 


Thr Ser Thr Gly Gly Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln 
305                 310                 315                 320 


Ile Tyr Gly Ser Arg Gln Ile Ile Leu Glu Lys Glu Glu Thr Glu Glu 
                325                 330                 335     


Leu Lys Arg Phe Asp Asp Pro Gly Leu Met Leu Met Gly Phe Lys Pro 
            340                 345                 350         


Leu Val Leu Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val 
        355                 360                 365             


Tyr Pro Glu Glu Ser Leu Val Ile Gly Ser Ser Thr Leu Phe Ser Ala 
    370                 375                 380                 


Leu Leu Ile Lys Cys Leu Glu Lys Glu Val Ala Ala Leu Cys Arg Tyr 
385                 390                 395                 400 


Thr Pro Arg Arg Asn Ile Pro Pro Tyr Phe Val Ala Leu Val Pro Gln 
                405                 410                 415     


Glu Glu Glu Leu Asp Asp Gln Lys Ile Gln Val Thr Pro Pro Gly Phe 
            420                 425                 430         


Gln Leu Val Phe Leu Pro Phe Ala Asp Asp Lys Arg Lys Met Pro Phe 
        435                 440                 445             


Thr Glu Lys Ile Met Ala Thr Pro Glu Gln Val Gly Lys Met Lys Ala 
    450                 455                 460                 


Ile Val Glu Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn 
465                 470                 475                 480 


Pro Val Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp 
                485                 490                 495     


Leu Met Glu Pro Glu Gln Ala Val Asp Leu Thr Leu Pro Lys Val Glu 
            500                 505                 510         


Ala Met Asn Lys Arg Leu Gly Ser Leu Val Asp Glu Phe Lys Glu Leu 
        515                 520                 525             


Val Tyr Pro Pro Asp Tyr Asn Pro Glu Gly Lys Val Thr Lys Arg Lys 
    530                 535                 540                 


His Asp Asn Glu Gly Ser Gly Ser Lys Arg Pro Lys Val Glu Tyr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys Phe 
                565                 570                 575     


Thr Val Pro Met Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys Ser 
            580                 585                 590         


Gly Leu Lys Lys Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe Gln 
        595                 600                 605             


Asp 
    


<210>  4072
<211>  1520
<212>  DNA
<213>  Homosapiens

<400>  4072
gccgcgcggg gccatttccg ctgctgcttc tgtgagtttt tccggtgcac gcgagtgctt     60

ctgaaacgtc agctgcgctc ccctaggagt gctgagcccg cggaaccgca gccatgactg    120

aggctgatgt gaatccaaag gcctatcccc ttgccgatgc ccacctcacc aagaagctac    180

tggacctcgt tcagcagtca tgtaactata agcagcttcg gaaaggagcc aatgaggcca    240

ccaaaaccct caacaggggc atctctgagt tcatcgtgat ggctgcagac gccgagccac    300

tggagatcat tctgcacctg ccgctgctgt gtgaagacaa gaatgtgccc tacgtgtttg    360

tgcgctccaa gcaggccctg gggagagcct gtggggtctc caggcctgtc atcgcctgtt    420

ctgtcaccat caaagaaggc tcgcagctga aacagcagat ccaatccatt cagcagtcca    480

ttgaaaggct cttagtctaa acctgtggcc tctgccacgt gctccctgcc agcttccccc    540

ctgaggttgt gtatcatatt atctgtgtta gcatgtagta ttttcagcta ctctctattg    600

ttataaaatg tagtactaaa tctggtttct ggatttttgt gttgtttttg ttctgtttta    660

cagggttgct atcccccttc ctttcctccc tccctctgcc atccttcatc cttttatcct    720

ccctttttgg aacaagtgtt cagagcagac agaagcaggg tggtggcacc gttgaaaggc    780

agaaagagcc aggagaaagc tgatggagcc aggacagaga tctggttcca gctttcagcc    840

actagcttcc tgttgtgtgc ggggtgtggt ggaattaaac agcattcatt gtgtgtccct    900

gtgcctggca cacagaatca ttcatacgtg ttcaagtgat caaggggttt catttgctct    960

tgggggatta ggtatcattt ggggaggaag catgtgttct gtgaggttgt tcggctatgt   1020

ccaagtgtcg tttactaatg tacccctgct gtttgctttt ggtaatgtga tgttgatgtt   1080

ctccccctac ccacaaccat gcccttgagg gtagcagggc agcagcatac caaagagatg   1140

tgctgcagga ctccggaggc agcctgggtg ggtgagccat ggggcagttg acctgggtct   1200

tgaaagagtc gggagtgaca agctcagaga gcatgaactg atgctggcat gaaggattcc   1260

aggaagatca tggagacctg gctggtagct gtaacagaga tggtggagtc caaggaaaca   1320

gcctgtctct ggtgaatggg actttctttg gtggacactt ggcaccagct ctgagagccc   1380

ttcccctgtg tcctgccacc atgtgggtca gatgtactct ctgtcacatg aggagagtgc   1440

tagttcatgt gttctccatt cttgtgagca tcctaataaa tctgttccat tttgatgaca   1500

aaaaaaaaaa aaaaaaaaaa                                               1520


<210>  4073
<211>  128
<212>  PRT
<213>  Homosapiens

<400>  4073

Met Thr Glu Ala Asp Val Asn Pro Lys Ala Tyr Pro Leu Ala Asp Ala 
1               5                   10                  15      


His Leu Thr Lys Lys Leu Leu Asp Leu Val Gln Gln Ser Cys Asn Tyr 
            20                  25                  30          


Lys Gln Leu Arg Lys Gly Ala Asn Glu Ala Thr Lys Thr Leu Asn Arg 
        35                  40                  45              


Gly Ile Ser Glu Phe Ile Val Met Ala Ala Asp Ala Glu Pro Leu Glu 
    50                  55                  60                  


Ile Ile Leu His Leu Pro Leu Leu Cys Glu Asp Lys Asn Val Pro Tyr 
65                  70                  75                  80  


Val Phe Val Arg Ser Lys Gln Ala Leu Gly Arg Ala Cys Gly Val Ser 
                85                  90                  95      


Arg Pro Val Ile Ala Cys Ser Val Thr Ile Lys Glu Gly Ser Gln Leu 
            100                 105                 110         


Lys Gln Gln Ile Gln Ser Ile Gln Gln Ser Ile Glu Arg Leu Leu Val 
        115                 120                 125             


<210>  4074
<211>  1601
<212>  DNA
<213>  Homosapiens

<400>  4074
ggagttacgt agaagacagg gcgtcctggt gtacgggctg gccctggacg tcacttccgc     60

tggcggcagt ggcgtcactt cctgctcttg ggggcggggc atccgtgtcc ttgcggtgct    120

gggcagcaga ccgtccaaac cgacacgcgt ggtatcctcg cggtgtccgg caagagacta    180

ccaagacaga cgctatgact gaggctgatg tgaatccaaa ggcctatccc cttgccgatg    240

cccacctcac caagaagcta ctggacctcg ttcagcagtc atgtaactat aagcagcttc    300

ggaaaggagc caatgaggcc accaaaaccc tcaacagggg catctctgag ttcatcgtga    360

tggctgcaga cgccgagcca ctggagatca ttctgcacct gccgctgctg tgtgaagaca    420

agaatgtgcc ctacgtgttt gtgcgctcca agcaggccct ggggagagcc tgtggggtct    480

ccaggcctgt catcgcctgt tctgtcacca tcaaagaagg ctcgcagctg aaacagcaga    540

tccaatccat tcagcagtcc attgaaaggc tcttagtcta aacctgtggc ctctgccacg    600

tgctccctgc cagcttcccc cctgaggttg tgtatcatat tatctgtgtt agcatgtagt    660

attttcagct actctctatt gttataaaat gtagtactaa atctggtttc tggatttttg    720

tgttgttttt gttctgtttt acagggttgc tatccccctt cctttcctcc ctccctctgc    780

catccttcat ccttttatcc tccctttttg gaacaagtgt tcagagcaga cagaagcagg    840

gtggtggcac cgttgaaagg cagaaagagc caggagaaag ctgatggagc caggacagag    900

atctggttcc agctttcagc cactagcttc ctgttgtgtg cggggtgtgg tggaattaaa    960

cagcattcat tgtgtgtccc tgtgcctggc acacagaatc attcatacgt gttcaagtga   1020

tcaaggggtt tcatttgctc ttgggggatt aggtatcatt tggggaggaa gcatgtgttc   1080

tgtgaggttg ttcggctatg tccaagtgtc gtttactaat gtacccctgc tgtttgcttt   1140

tggtaatgtg atgttgatgt tctcccccta cccacaacca tgcccttgag ggtagcaggg   1200

cagcagcata ccaaagagat gtgctgcagg actccggagg cagcctgggt gggtgagcca   1260

tggggcagtt gacctgggtc ttgaaagagt cgggagtgac aagctcagag agcatgaact   1320

gatgctggca tgaaggattc caggaagatc atggagacct ggctggtagc tgtaacagag   1380

atggtggagt ccaaggaaac agcctgtctc tggtgaatgg gactttcttt ggtggacact   1440

tggcaccagc tctgagagcc cttcccctgt gtcctgccac catgtgggtc agatgtactc   1500

tctgtcacat gaggagagtg ctagttcatg tgttctccat tcttgtgagc atcctaataa   1560

atctgttcca ttttgatgac aaaaaaaaaa aaaaaaaaaa a                       1601


<210>  4075
<211>  128
<212>  PRT
<213>  Homosapiens

<400>  4075

Met Thr Glu Ala Asp Val Asn Pro Lys Ala Tyr Pro Leu Ala Asp Ala 
1               5                   10                  15      


His Leu Thr Lys Lys Leu Leu Asp Leu Val Gln Gln Ser Cys Asn Tyr 
            20                  25                  30          


Lys Gln Leu Arg Lys Gly Ala Asn Glu Ala Thr Lys Thr Leu Asn Arg 
        35                  40                  45              


Gly Ile Ser Glu Phe Ile Val Met Ala Ala Asp Ala Glu Pro Leu Glu 
    50                  55                  60                  


Ile Ile Leu His Leu Pro Leu Leu Cys Glu Asp Lys Asn Val Pro Tyr 
65                  70                  75                  80  


Val Phe Val Arg Ser Lys Gln Ala Leu Gly Arg Ala Cys Gly Val Ser 
                85                  90                  95      


Arg Pro Val Ile Ala Cys Ser Val Thr Ile Lys Glu Gly Ser Gln Leu 
            100                 105                 110         


Lys Gln Gln Ile Gln Ser Ile Gln Gln Ser Ile Glu Arg Leu Leu Val 
        115                 120                 125             


<210>  4076
<211>  4992
<212>  DNA
<213>  Homosapiens

<400>  4076
ggctatccta ctgcagctgg ctgcatcaga tgtgccaggc ctgccctcta gctcccaaca     60

ccatctgcct gatctaagct ttgccatgtt gttgtcactg ctgggtgcct gtgctgtggt    120

ggggccattc catggccctg agtgggagcc agtgcagggc ctgctctccc agaatcacag    180

ctgcagggac cctcagtgct gtggcaacct gcttgtcctc tgcctctttc tggtctggca    240

ggtccggcac tgttggcacc aggtcaccag gacccgcttc agcacaagga atgtcatcaa    300

ggtgccactg cagaagcggg cagtgccctc catgaggtgc gaaactgtct tcaagctgac    360

tcctgaattc ttcagtcctg gaaagtccag gggcctagat tctcaacaat gcgcacaaag    420

gcagagatgg ggataccgga ggagcctcca ggaatcatgg gcccagaacc tgctctctcc    480

acagcaccca tgtccaggcc caccttcggg tgtccacacc cactctgagc ccatcttttg    540

taccacctcc atttcaaaca cctgtttact gcctcagaac agttcctgga aagcatggca    600

ggtgccttgg tgtctccatg atggtcagac tcgccctgcc ttggacatgt gtcaagagat    660

ggagcagctg ctgcttcact cacaggaaag gttggtgtca ctggagcctg tcatcagtgt    720

gaggtctcgc cccacctcca tgaccttaac cacctctctt ccaaacttac tttcagctga    780

gaggctgcag ttctgccccc agagagctcc tgcctgatcc ttcccaccaa acactgagaa    840

tgtgcacttg gaagtcttgg cactgtcgac cagaggcctg ggaaccaggg ggtaaaaacc    900

agaaagcagg cagagaggat agtagagaga cccaggctcc aaggtgggtg aaccagacag    960

ggagcagacg ggaggatgct tcagaaatcc aggcatctgg ggagtagttc ccagtagact   1020

ttggaatgga gggtgatgca gagactaacg tgttggagtg tgcaaaccag agactagtaa   1080

taagtgaaac tgatggcgag atcttgacac cagggtggga cacccaggac cggatgggag   1140

ttgagagtag aaccaacatt caggaactag ggaatagaaa ccagagggag gctggaggtg   1200

agaatctccc tgaaacccag gcacatatgg gagagaacca agaacagtta agatgtaaaa   1260

ttgatgcaga gacccaaaca cctgagtggg agaaccagga taagaatgga agtgaggatg   1320

ctgtggagac ccagacattt gagaagaagg acaagaaaga ggctggagag gaggatgggg   1380

aagagatcca ggctcaagga ttggggaagc aaggccagac tggagatgag aatggtgagg   1440

agacccagac accacagtgg gagaaacaag atcagatgaa aggtgatgcg gatgtggaaa   1500

ttcagatgga agaggggaga aacaaggatc aggttggagg tcaggatgct gcacaaaccc   1560

aatcatgtgg gagggagaac gtgggagaag taaaaaaaga gaatagtgta gagacccagg   1620

ccttggattg gggaaaacag gaatgtgttg gaaatgggaa tgttacagag atccagacac   1680

caaggtggga gaagcatgat caaggtggaa gtaagaaagc taagaagacc caagcatctg   1740

ggggagagaa ccagaaacaa ttaagtcatg aaattcaagt ggggtgggga aataagggcc   1800

tgagaagaga tgaagatgct aaggaaaccc agatagctac caagaagaag ctcagggaga   1860

taagagaagg attgggtggt gatccaggca ctatggtggg gaaaccggag acaagtagca   1920

agtgaaattt atagagaatt tgagatacta tgttgggaga atcagaactg gattggaggt   1980

gaacatagag cagaaattca ggcatcagag aagagagacc aaagaaagga tggatgtgag   2040

gatggcacaa atatcctggc acccgaggct gagatccagg aacaattaaa aggtgaaact   2100

gatgtggaga ctcagagcaa tgagccactt agagaagagg atggtacaga cattcagtca   2160

ctagggagga gagaggttaa aggtgaggat gataaagaca cccaggaact tgggaggaaa   2220

aatcagggtc agttaggaaa tgaatttagt ggaaagattc acataccaaa ggggaagaat   2280

caggaacata ttagaggcga agatggtgca catacccaga tatctgagtc agggaactgg   2340

ggcaaattaa caagtcaaat tgatggagaa atgcattcag cagaatggaa gaaagatcag   2400

cagattggag gtgagaatgg ggcagaaatt cagatacaag ggaagagaaa cctgagagaa   2460

gttggaggtg aggacggtgt aaagacctgg gcacctggga aagaaaccca gagtcagttt   2520

agaagtgatc ttggtagaaa gatcctttta tcagagtgga agagccagaa gcagatggga   2580

agtgagaatg gaacagaaat tcaggctcca gtggagagaa accagagaga acctggaggt   2640

gaggacggtg taaagactca gagacctaag agagagaacg aggaccagtt agatagtgaa   2700

attggaggga gccattcacc agggaggagg aactgggagc tgattggaaa ggatgttgca   2760

gaaaatcagg catcagagaa gagaaaccag agagaggttg gaaacgagga cggtagaatg   2820

atctggaggc ttaggggaaa aaactggagg cttagagcga agaaacagac tgttaaaaag   2880

taaagataat ggaaagaccc gtttatcaga gtggaagaac caggaacagg gtggaggtgg   2940

gaatgatgaa gaaattcaaa tacaggggaa gagaaacctg agagggacca cagctgatga   3000

tggtacagag acccaggctc ctgcaggaga tgaccaggga cagttaagag ttgaaattgc   3060

tgaagagatc caggtacaag ggcaaggaaa taagaatgac ggtggagttg aggatgttgc   3120

agaactccag gatataggaa gccagagaaa gtgcacagat gaggatgttg gagagcctcg   3180

agcaccaagg ggaggaaaca aggatctggt cagaggagag gatgctgtga gggacagtct   3240

ccaagtcgac tgttctggga gtgagaggcc cacaggcagg aagcacagcc taccatggcc   3300

tccagccttc actggctatg gatgtgggac ccgggaacag gaacaggcag tggctgtgaa   3360

tggtttcatc tctgccccct gtcctgagat gaatcctgtc ccccactggg gtgaagtctt   3420

cctgctggtg ggtggggagg gagagcatct ggccagccag ggcacaaccc ctgccaggga   3480

tcatagagtg gggatcagtc cagcctccca gcaggcccaa cctgaatcct ggagaagacg   3540

acaaagggac aaaggggtgg atccagagaa ggcccccagc ctgactcggc agtcccaaaa   3600

ccctccgtct ctgacagctc ccttgggcat gccctctgcc tgctcctgtc tcccgtgtgg   3660

cccagccccg gaagctgcca tcattctagc gggtcctccc accgccctca ctgtcctgcc   3720

caaggggaca ggcctcaaga agagcaaacg actgctcctg gagtccctca tgcggaggag   3780

gattgcacac ctgaagtggg gtcttccccg gcggatcctg gagtcctatt tcctgtttaa   3840

cttcttagga tcttgctcat tgacccttgc tggggcgagg ctctctggac tgaacacagg   3900

ccaggagctc caagcccagc aggaaaggta ttgtgaggcc caaggctccc caccaggcct   3960

taagtcccca gagaggttcc agagggttca gcgcccagac agaaaaagct cgaaacttcc   4020

tatacaagcc agagctctgg agaggaacag accgcacatg tcagagccca ttaagcattt   4080

ccatccagcc tgaaaaggcc aggagagtca ggccaccagg gggcgccaga gaaccacagg   4140

agatccagga agcgcttgct aggaccaagc tcccagctcc caggaccccc aggccggcag   4200

cggagtccag gagctggtgt ggcccacaaa gggtcggaga gcctcccagt gagaacagta   4260

ggggcaggaa aatgatcagg tcaagggtct cccagctggc agagagggct cccagcagag   4320

tgaggacttc attctctagg gcagaccacg cccactggag gaaggaatgt acatcctggg   4380

aggcctctaa gctccccaga ctcaaatgcc agcagctcac atactggaga agaggaagcc   4440

tggaatctac agggtgcaga ggggctgggc agcagccttc ctgccattct gcagaacctg   4500

tcagcttcaa agggaggctc cactctgcgg tggcaaagct gggcctgacc cttctggcca   4560

agatgtcctg gtccccacag ctcgccaagc gcaagcactt ggcccctaac ctgagcctga   4620

gggaacctga ttctactctg cctcccaaag tgggtgatcc tcgtgcaggg gaggacagca   4680

tcggagatca cactgcttca cagagggatc ttcagctgca aggtcactgc tgtactgggg   4740

ccacccttcc taagacagag agtccccagg gccaggaggc acctgggaac ccaaatgggg   4800

ctccacagaa tacacgagcc tccaaaaagt ttagtattat gaagcatctg aatttttttt   4860

ctcttccaga atggctttaa aaagtagact caggcccaga gtcctcagga catatcagaa   4920

aagctttgag agtgtcctga tccctgcaaa gcctctaata aattggtcat ttgggcaaaa   4980

aaaaaaaaaa aa                                                       4992


<210>  4077
<211>  234
<212>  PRT
<213>  Homosapiens

<400>  4077

Met Asn Pro Val Pro His Trp Gly Glu Val Phe Leu Leu Val Gly Gly 
1               5                   10                  15      


Glu Gly Glu His Leu Ala Ser Gln Gly Thr Thr Pro Ala Arg Asp His 
            20                  25                  30          


Arg Val Gly Ile Ser Pro Ala Ser Gln Gln Ala Gln Pro Glu Ser Trp 
        35                  40                  45              


Arg Arg Arg Gln Arg Asp Lys Gly Val Asp Pro Glu Lys Ala Pro Ser 
    50                  55                  60                  


Leu Thr Arg Gln Ser Gln Asn Pro Pro Ser Leu Thr Ala Pro Leu Gly 
65                  70                  75                  80  


Met Pro Ser Ala Cys Ser Cys Leu Pro Cys Gly Pro Ala Pro Glu Ala 
                85                  90                  95      


Ala Ile Ile Leu Ala Gly Pro Pro Thr Ala Leu Thr Val Leu Pro Lys 
            100                 105                 110         


Gly Thr Gly Leu Lys Lys Ser Lys Arg Leu Leu Leu Glu Ser Leu Met 
        115                 120                 125             


Arg Arg Arg Ile Ala His Leu Lys Trp Gly Leu Pro Arg Arg Ile Leu 
    130                 135                 140                 


Glu Ser Tyr Phe Leu Phe Asn Phe Leu Gly Ser Cys Ser Leu Thr Leu 
145                 150                 155                 160 


Ala Gly Ala Arg Leu Ser Gly Leu Asn Thr Gly Gln Glu Leu Gln Ala 
                165                 170                 175     


Gln Gln Glu Arg Tyr Cys Glu Ala Gln Gly Ser Pro Pro Gly Leu Lys 
            180                 185                 190         


Ser Pro Glu Arg Phe Gln Arg Val Gln Arg Pro Asp Arg Lys Ser Ser 
        195                 200                 205             


Lys Leu Pro Ile Gln Ala Arg Ala Leu Glu Arg Asn Arg Pro His Met 
    210                 215                 220                 


Ser Glu Pro Ile Lys His Phe His Pro Ala 
225                 230                 


<210>  4078
<211>  1279
<212>  DNA
<213>  Homosapiens

<400>  4078
ctttcagttg ctttgctgtt agcctgttgg accttcgagc ctagctgctc gcacaggact     60

cggccacctg cccttcctgc accgactggc cagctcaaga ggtttggata tggaccttct    120

tcaattcctg gccttcctct ttgtcctgct tttgtctggg atgggagcca caggcacctt    180

gaggacctcc ctggacccaa gcctggagat ctacaagaag atgtttgagg tgaagcggcg    240

ggagcagctg ttggcactga agaacctggc acagctgaac gacatccacc agcagtacaa    300

gatccttgat gtcatgctca aggggctctt taaggtgctg gaggactccc ggacagtgct    360

caccgctgct gatgtgctcc cagatgggcc cttcccccag gacgagaagc tgaaggatgc    420

tttctcccac gtggtggaga acacggcctt cttcggcgat gtggtgctgc gcttcccgag    480

gattgtgcac tattactttg accacaactc caactggaac ctcctcatcc gctggggtat    540

cagtttctgc aaccagacag gcgtcttcaa ccaggggccc cactcgccca tcctcagcct    600

gatggcccag gagctgggga tcagtgagaa agactccaac ttccagaacc catttaaaat    660

cgaccgcaca gagttcattc ccagcactga ccctttccag aaggccctga gagaagaaga    720

gaaacgccga aagaaagagg agaagcggaa ggagatccga aaaggcccaa ggatctccag    780

atcccagtct gagttatagc cctggagcag ctcagggctc agggggccac aaggaggcag    840

gtcgggagga agaagaggtg gaggtgtggt tgtggtggag agcaccagct agccccttcc    900

agaaggggag gccacatttg cccggccccc tggagctggg tctgagcccc agctgaaggg    960

actgagcctc agatggctgg attttctctc aggggcctcc tgctgaaggg gccttcagag   1020

gattttatgc tggaaatatg accctgtgca gactgctggg ggaggcagga ggatgcctgc   1080

ctggaccctg ttggtggctg aagacctctg gccagctggc ttccgccctt ggtggggaag   1140

cagcagaact aggttctgag ccacgggtca gggtgccacc ctgctgctgg ccccactgtg   1200

tcacagagct gcctggcaca ggtcccagcc cctctgcaga gacacaataa aagccagcag   1260

accctttgga ccgacaaaa                                                1279


<210>  4079
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  4079

Met Asp Leu Leu Gln Phe Leu Ala Phe Leu Phe Val Leu Leu Leu Ser 
1               5                   10                  15      


Gly Met Gly Ala Thr Gly Thr Leu Arg Thr Ser Leu Asp Pro Ser Leu 
            20                  25                  30          


Glu Ile Tyr Lys Lys Met Phe Glu Val Lys Arg Arg Glu Gln Leu Leu 
        35                  40                  45              


Ala Leu Lys Asn Leu Ala Gln Leu Asn Asp Ile His Gln Gln Tyr Lys 
    50                  55                  60                  


Ile Leu Asp Val Met Leu Lys Gly Leu Phe Lys Val Leu Glu Asp Ser 
65                  70                  75                  80  


Arg Thr Val Leu Thr Ala Ala Asp Val Leu Pro Asp Gly Pro Phe Pro 
                85                  90                  95      


Gln Asp Glu Lys Leu Lys Asp Ala Phe Ser His Val Val Glu Asn Thr 
            100                 105                 110         


Ala Phe Phe Gly Asp Val Val Leu Arg Phe Pro Arg Ile Val His Tyr 
        115                 120                 125             


Tyr Phe Asp His Asn Ser Asn Trp Asn Leu Leu Ile Arg Trp Gly Ile 
    130                 135                 140                 


Ser Phe Cys Asn Gln Thr Gly Val Phe Asn Gln Gly Pro His Ser Pro 
145                 150                 155                 160 


Ile Leu Ser Leu Met Ala Gln Glu Leu Gly Ile Ser Glu Lys Asp Ser 
                165                 170                 175     


Asn Phe Gln Asn Pro Phe Lys Ile Asp Arg Thr Glu Phe Ile Pro Ser 
            180                 185                 190         


Thr Asp Pro Phe Gln Lys Ala Leu Arg Glu Glu Glu Lys Arg Arg Lys 
        195                 200                 205             


Lys Glu Glu Lys Arg Lys Glu Ile Arg Lys Gly Pro Arg Ile Ser Arg 
    210                 215                 220                 


Ser Gln Ser Glu Leu 
225                 


<210>  4080
<211>  4325
<212>  DNA
<213>  Homosapiens

<400>  4080
gccctttctg tgcggcgccc gggcgcaacg caaacatggc ggcgggtggc acccgtcggt     60

gaggcggtgc cgggcggggg ttgtcgggtg tcatgggcgg tggcgacggc accgcccccg    120

cgtctccctg agcgggacgg cagggggggc ttctgcgctg agccgggcga tggacgacag    180

cggcgagctg ggtggtctgg agaccatgga gaccctcacg gagctgggcg acgagctgac    240

cctgggagac atcgacgaga tgctgcaatt tgtcagtaat caagtgggag agttccctga    300

cttgttttca gaacagctgt gtagctcctt tcctggcagt ggtggtagtg gtagcagcag    360

cggcagcagt ggcagcagca gcagcagcag caatggcagg ggcagcagca gcggagctgt    420

ggacccttca gtgcaacggt cattcaccca ggtcacatta ccttccttct ctccctcggc    480

ggcctcccca caggctccaa ctctgcaagt caaggtttct cccacctcag ttcccaccac    540

acccagggca actcctattc ttcagccccg cccccagccc cagcctcaac ctcaaactca    600

gctgcaacaa cagacggtaa tgatcacgcc aacattcagc accactccgc agacgaggat    660

catccagcag cctttgatat accagaatgc agctactagc tttcaagtcc ttcagcctca    720

agtccaaagc ctggtgacat cctcccaggt acagccggtc accattcagc agcaggtgca    780

gacagtacag gcccagcggg tgctgacaca aacggccaat ggcacgctgc agacccttgc    840

cccggctacg gtgcagacag ttgctgcgcc acaggtgcag caggtcccgg tcctggtcca    900

gcctcagatc atcaagacag attcccttgt tttgaccaca ctgaagacag atggcagccc    960

tgttatggct gcggtccaga acccggccct caccgccctc accaccccta tccagacggc   1020

tgcccttcaa gtaccaaccc tggtgggcag cagtgggacc attctgacca caatgcctgt   1080

aatgatgggg caagagaaag tgcccattaa gcaggtacct gggggagtca agcagcttga   1140

gccccccaaa gaaggagaaa ggcggacaac ccataatatc attgagaaac gatatcgctc   1200

ctccatcaat gacaaaatca tcgaattgaa agacctggtc atggggacag acgccaagat   1260

gcacaagtct ggcgttctga ggaaggccat tgattacatc aaatacttgc agcaggtcaa   1320

tcataaactg cgccaggaga acatggtgct gaagctggca aatcaaaaga acaagcttct   1380

aaagggcatc gacctaggca gtctggtgga caatgaggtg gacctgaaga tcgaggactt   1440

taatcagaat gtccttctga tgtccccccc agcctctgac tcagggtccc aggctggctt   1500

ctctccctac tccattgact ctgagccagg aagccctcta ttggatgatg caaaggtcaa   1560

agatgagcca gactctcctc ctgtggcgct gggcatggta gaccgctcac ggattcttct   1620

gtgtgtcctc accttcctgt gcctctcctt taaccccctg acttccctgc tgcagtgggg   1680

aggggcccac gactctgacc agcacccaca ctcaggctct ggccgcagtg tcctgtcatt   1740

cgagtcaggt tctgggggct ggtttgactg gatgatgcct actcttctct tatggctggt   1800

aaatggtgtg attgtcctga gcgtctttgt gaagctgctg gttcatgggg agccagtgat   1860

ccggccacac tcgcgctcct cggtcacctt ctggaggcac cggaaacagg cagatctgga   1920

tctcgccaga ggagattttg cagctgctgc cggcaaccta caaacctgcc tggcagtttt   1980

gggccgggca ctgcccacct cccgcctgga cctggcctgc agcctctcct ggaacgtgat   2040

ccgctacagc ctgcagaagc tacgcctggt gcgctggctg ctcaagaaag tcttccagtg   2100

ccggcgggcc acgccagcca ctgaggcagg ctttgaagac gaagctaaga ccagcgcccg   2160

ggatgcggct ctggcctatc accggctgca ccagctgcac atcacaggga agcttcctgc   2220

aggatccgcc tgttccgatg tacacatggc gttgtgtgcc gtgaacctgg ctgaatgtgc   2280

agaggagaag atcccaccga gcacactggt tgagatccat ctgactgctg ccatggggct   2340

caagacccgg tgtggaggca agctgggctt cctggccagc tacttcctca gccgagccca   2400

gagcctgtgt ggccccgagc acagtgctgt tcctgactcc ctgcgctggc tctgccaccc   2460

cctgggccag aagtttttca tggagcggag ctggtctgtg aagtcagctg ccaaggagag   2520

tctatactgt gcccagagga acccagctga ccccattgcg caggtccacc aggccttctg   2580

caagaacctg ctggagcgag ctatagagtc cttggtgaaa cctcaggcca agaagaaggc   2640

tggagaccag gaagaagaga gctgtgaatt ctccagtgct ctggagtact tgaaattact   2700

tcattctttt gtggactctg tgggggttat gagcccccca ctctccagga gctccgtgct   2760

caagtccgcc ctgggtccag acatcatctg tcggtggtgg acgtctgcaa tcactgtggc   2820

catcagctgg ctccagggag acgatgcagc tgtgcgctct cattttacca aagtggaacg   2880

catccccaag gccctggaag tgacagagag ccccctggtg aaggccatct tccatgcctg   2940

cagagccatg catgcctcac tccctgggaa agcagatggg cagcagagtt ccttctgcca   3000

ttgcgagagg gccagtggcc acctatggag cagcctcaac gtcagtgggg ccacctctga   3060

ccctgccctc aaccacgtgg tccagctgct cacctgtgac ctgctactgt cgctacggac   3120

agcgctctgg caaaaacagg ccagtgccag ccaggctgtg ggggagacct accacgcgtc   3180

aggcgctgaa ctggcgggct tccaacggga cctgggcagc ctgcgcaggc tggcacacag   3240

cttccgccca gcataccgca aggtgttcct gcatgaagcc accgtgcgcc tgatggcagg   3300

agccagcccc acccgcaccc accagctgct ggaacacagc ctgcggcggc gcaccacgca   3360

gagcaccaag cacggagagg tggatgcctg gcccggccag cgagagcggg ccaccgccat   3420

cctgctggcc tgccgccacc tgcccctctc cttcctctcc tccccgggcc agcgggcagt   3480

gctgctggcc gaagctgccc gcaccctgga gaaggtgggc gaccggcgct cctgcaacga   3540

ctgccagcag atgattgtta agctgggtgg tggcactgcc attgccgcct cctgaccacc   3600

aggctcagcc cacccctcca cctctctctc gatttctctc tctccccctc agcatcttcc   3660

cgctgagagt ggtggggaag agccttgtct tcttagctgt cacctgccga ggcttctggg   3720

ccactcaggc cagtgcaccc ctgggcagag ccccttaaag ctgctgtcac tagatgccca   3780

tggtccaggg cctggtgggc gtgagaggat aggtggcagg gcagaaactg ggcagccctg   3840

acttgatagc agcaggggga gctcccaagc tgccaagccc ctgcctccag ccttcctgag   3900

tttctctctc ctgaacccta ctctctcctt tttgcttcct cagtttttat caggctttct   3960

ctgggggaca gcagtctctg agcaccaggg agcagttgcc ctcaggcctg tgcccagcat   4020

gccctcccct ttttatacga atgttttcta ccagtgtgct tgggtttgcc atgatgcgag   4080

gctgagttgc tgtagcgtct tgattctctc cctgggtctg cgttccctcc cctgggcctg   4140

actgagcctg ctcattgttt ttccctttat tacacaggac agccagggga ggaggggggc   4200

ccagccctgg gaggctggtg ggaggcaggg ggcaggcctg cggatgcatg aaataatgtt   4260

ggcattattt tttaattttt taaaaaataa atggtatctt atttaaaaaa aaaaaaaaaa   4320

aaaaa                                                               4325


<210>  4081
<211>  1141
<212>  PRT
<213>  Homosapiens

<400>  4081

Met Asp Asp Ser Gly Glu Leu Gly Gly Leu Glu Thr Met Glu Thr Leu 
1               5                   10                  15      


Thr Glu Leu Gly Asp Glu Leu Thr Leu Gly Asp Ile Asp Glu Met Leu 
            20                  25                  30          


Gln Phe Val Ser Asn Gln Val Gly Glu Phe Pro Asp Leu Phe Ser Glu 
        35                  40                  45              


Gln Leu Cys Ser Ser Phe Pro Gly Ser Gly Gly Ser Gly Ser Ser Ser 
    50                  55                  60                  


Gly Ser Ser Gly Ser Ser Ser Ser Ser Ser Asn Gly Arg Gly Ser Ser 
65                  70                  75                  80  


Ser Gly Ala Val Asp Pro Ser Val Gln Arg Ser Phe Thr Gln Val Thr 
                85                  90                  95      


Leu Pro Ser Phe Ser Pro Ser Ala Ala Ser Pro Gln Ala Pro Thr Leu 
            100                 105                 110         


Gln Val Lys Val Ser Pro Thr Ser Val Pro Thr Thr Pro Arg Ala Thr 
        115                 120                 125             


Pro Ile Leu Gln Pro Arg Pro Gln Pro Gln Pro Gln Pro Gln Thr Gln 
    130                 135                 140                 


Leu Gln Gln Gln Thr Val Met Ile Thr Pro Thr Phe Ser Thr Thr Pro 
145                 150                 155                 160 


Gln Thr Arg Ile Ile Gln Gln Pro Leu Ile Tyr Gln Asn Ala Ala Thr 
                165                 170                 175     


Ser Phe Gln Val Leu Gln Pro Gln Val Gln Ser Leu Val Thr Ser Ser 
            180                 185                 190         


Gln Val Gln Pro Val Thr Ile Gln Gln Gln Val Gln Thr Val Gln Ala 
        195                 200                 205             


Gln Arg Val Leu Thr Gln Thr Ala Asn Gly Thr Leu Gln Thr Leu Ala 
    210                 215                 220                 


Pro Ala Thr Val Gln Thr Val Ala Ala Pro Gln Val Gln Gln Val Pro 
225                 230                 235                 240 


Val Leu Val Gln Pro Gln Ile Ile Lys Thr Asp Ser Leu Val Leu Thr 
                245                 250                 255     


Thr Leu Lys Thr Asp Gly Ser Pro Val Met Ala Ala Val Gln Asn Pro 
            260                 265                 270         


Ala Leu Thr Ala Leu Thr Thr Pro Ile Gln Thr Ala Ala Leu Gln Val 
        275                 280                 285             


Pro Thr Leu Val Gly Ser Ser Gly Thr Ile Leu Thr Thr Met Pro Val 
    290                 295                 300                 


Met Met Gly Gln Glu Lys Val Pro Ile Lys Gln Val Pro Gly Gly Val 
305                 310                 315                 320 


Lys Gln Leu Glu Pro Pro Lys Glu Gly Glu Arg Arg Thr Thr His Asn 
                325                 330                 335     


Ile Ile Glu Lys Arg Tyr Arg Ser Ser Ile Asn Asp Lys Ile Ile Glu 
            340                 345                 350         


Leu Lys Asp Leu Val Met Gly Thr Asp Ala Lys Met His Lys Ser Gly 
        355                 360                 365             


Val Leu Arg Lys Ala Ile Asp Tyr Ile Lys Tyr Leu Gln Gln Val Asn 
    370                 375                 380                 


His Lys Leu Arg Gln Glu Asn Met Val Leu Lys Leu Ala Asn Gln Lys 
385                 390                 395                 400 


Asn Lys Leu Leu Lys Gly Ile Asp Leu Gly Ser Leu Val Asp Asn Glu 
                405                 410                 415     


Val Asp Leu Lys Ile Glu Asp Phe Asn Gln Asn Val Leu Leu Met Ser 
            420                 425                 430         


Pro Pro Ala Ser Asp Ser Gly Ser Gln Ala Gly Phe Ser Pro Tyr Ser 
        435                 440                 445             


Ile Asp Ser Glu Pro Gly Ser Pro Leu Leu Asp Asp Ala Lys Val Lys 
    450                 455                 460                 


Asp Glu Pro Asp Ser Pro Pro Val Ala Leu Gly Met Val Asp Arg Ser 
465                 470                 475                 480 


Arg Ile Leu Leu Cys Val Leu Thr Phe Leu Cys Leu Ser Phe Asn Pro 
                485                 490                 495     


Leu Thr Ser Leu Leu Gln Trp Gly Gly Ala His Asp Ser Asp Gln His 
            500                 505                 510         


Pro His Ser Gly Ser Gly Arg Ser Val Leu Ser Phe Glu Ser Gly Ser 
        515                 520                 525             


Gly Gly Trp Phe Asp Trp Met Met Pro Thr Leu Leu Leu Trp Leu Val 
    530                 535                 540                 


Asn Gly Val Ile Val Leu Ser Val Phe Val Lys Leu Leu Val His Gly 
545                 550                 555                 560 


Glu Pro Val Ile Arg Pro His Ser Arg Ser Ser Val Thr Phe Trp Arg 
                565                 570                 575     


His Arg Lys Gln Ala Asp Leu Asp Leu Ala Arg Gly Asp Phe Ala Ala 
            580                 585                 590         


Ala Ala Gly Asn Leu Gln Thr Cys Leu Ala Val Leu Gly Arg Ala Leu 
        595                 600                 605             


Pro Thr Ser Arg Leu Asp Leu Ala Cys Ser Leu Ser Trp Asn Val Ile 
    610                 615                 620                 


Arg Tyr Ser Leu Gln Lys Leu Arg Leu Val Arg Trp Leu Leu Lys Lys 
625                 630                 635                 640 


Val Phe Gln Cys Arg Arg Ala Thr Pro Ala Thr Glu Ala Gly Phe Glu 
                645                 650                 655     


Asp Glu Ala Lys Thr Ser Ala Arg Asp Ala Ala Leu Ala Tyr His Arg 
            660                 665                 670         


Leu His Gln Leu His Ile Thr Gly Lys Leu Pro Ala Gly Ser Ala Cys 
        675                 680                 685             


Ser Asp Val His Met Ala Leu Cys Ala Val Asn Leu Ala Glu Cys Ala 
    690                 695                 700                 


Glu Glu Lys Ile Pro Pro Ser Thr Leu Val Glu Ile His Leu Thr Ala 
705                 710                 715                 720 


Ala Met Gly Leu Lys Thr Arg Cys Gly Gly Lys Leu Gly Phe Leu Ala 
                725                 730                 735     


Ser Tyr Phe Leu Ser Arg Ala Gln Ser Leu Cys Gly Pro Glu His Ser 
            740                 745                 750         


Ala Val Pro Asp Ser Leu Arg Trp Leu Cys His Pro Leu Gly Gln Lys 
        755                 760                 765             


Phe Phe Met Glu Arg Ser Trp Ser Val Lys Ser Ala Ala Lys Glu Ser 
    770                 775                 780                 


Leu Tyr Cys Ala Gln Arg Asn Pro Ala Asp Pro Ile Ala Gln Val His 
785                 790                 795                 800 


Gln Ala Phe Cys Lys Asn Leu Leu Glu Arg Ala Ile Glu Ser Leu Val 
                805                 810                 815     


Lys Pro Gln Ala Lys Lys Lys Ala Gly Asp Gln Glu Glu Glu Ser Cys 
            820                 825                 830         


Glu Phe Ser Ser Ala Leu Glu Tyr Leu Lys Leu Leu His Ser Phe Val 
        835                 840                 845             


Asp Ser Val Gly Val Met Ser Pro Pro Leu Ser Arg Ser Ser Val Leu 
    850                 855                 860                 


Lys Ser Ala Leu Gly Pro Asp Ile Ile Cys Arg Trp Trp Thr Ser Ala 
865                 870                 875                 880 


Ile Thr Val Ala Ile Ser Trp Leu Gln Gly Asp Asp Ala Ala Val Arg 
                885                 890                 895     


Ser His Phe Thr Lys Val Glu Arg Ile Pro Lys Ala Leu Glu Val Thr 
            900                 905                 910         


Glu Ser Pro Leu Val Lys Ala Ile Phe His Ala Cys Arg Ala Met His 
        915                 920                 925             


Ala Ser Leu Pro Gly Lys Ala Asp Gly Gln Gln Ser Ser Phe Cys His 
    930                 935                 940                 


Cys Glu Arg Ala Ser Gly His Leu Trp Ser Ser Leu Asn Val Ser Gly 
945                 950                 955                 960 


Ala Thr Ser Asp Pro Ala Leu Asn His Val Val Gln Leu Leu Thr Cys 
                965                 970                 975     


Asp Leu Leu Leu Ser Leu Arg Thr Ala Leu Trp Gln Lys Gln Ala Ser 
            980                 985                 990         


Ala Ser Gln Ala Val Gly Glu Thr  Tyr His Ala Ser Gly  Ala Glu Leu 
        995                 1000                 1005             


Ala Gly  Phe Gln Arg Asp Leu  Gly Ser Leu Arg Arg  Leu Ala His 
    1010                 1015                 1020             


Ser Phe  Arg Pro Ala Tyr Arg  Lys Val Phe Leu His  Glu Ala Thr 
    1025                 1030                 1035             


Val Arg  Leu Met Ala Gly Ala  Ser Pro Thr Arg Thr  His Gln Leu 
    1040                 1045                 1050             


Leu Glu  His Ser Leu Arg Arg  Arg Thr Thr Gln Ser  Thr Lys His 
    1055                 1060                 1065             


Gly Glu  Val Asp Ala Trp Pro  Gly Gln Arg Glu Arg  Ala Thr Ala 
    1070                 1075                 1080             


Ile Leu  Leu Ala Cys Arg His  Leu Pro Leu Ser Phe  Leu Ser Ser 
    1085                 1090                 1095             


Pro Gly  Gln Arg Ala Val Leu  Leu Ala Glu Ala Ala  Arg Thr Leu 
    1100                 1105                 1110             


Glu Lys  Val Gly Asp Arg Arg  Ser Cys Asn Asp Cys  Gln Gln Met 
    1115                 1120                 1125             


Ile Val  Lys Leu Gly Gly Gly  Thr Ala Ile Ala Ala  Ser 
    1130                 1135                 1140     


<210>  4082
<211>  1263
<212>  DNA
<213>  Homosapiens

<400>  4082
atggcgcggg ccggggcgcg gggactgctc ggcggccgcc gtcctcccgg cctccggctc     60

gcgctcgcgc ttcggctcgc gttgctgctg gcgcggccgc cgtcgggccg cgcgggagcc    120

cccgaggcgc agggtcccgc ggcgcccggc acgacagccc cggagggggg cgaccgctgc    180

cgcggctact acgacgtgat gggccagtgg gacccgccct tcaactgcag ctccggagcc    240

tacagcttct gctgcggcac gtgcggctac cgcttctgct gccacgacgg gccgcggcgc    300

ctcgaccaga gccgctgttc caactacgac acgccggcct gggtccagac aggccggccg    360

cccgcccgcg cccgcgacac cgcagcgccc cgggaccccg gccgcgagcg cagccatacg    420

gccgtctacg ctgtgtgcgg cgtcgcagcg ctgctggtgc tggccggcat cggggcgcgc    480

ctgggactgg agagggcgca cagcccgcgc gcgcggcgca cagtgaccag ggcgctgaca    540

gagcttctga agcagccggg cccccaggag ccactgcctc ccaccctggg cccacccctg    600

ggtggctgtg tccaggtgca gatgggggac ggcctccccc ggggctcccc ccacaacagc    660

gcaggtccca ggactccgcg cctggctcga gcgtcgcctc cgggcgagcc gttcatgagg    720

gtggcacccc ccgggctggc tgccgccgcc gctgcgcgtg actcggagcc aggccctgtt    780

ccaggcgctg gaggctgcgg cgaagacagg cttggctcgc agcctcgccc ggagaacggt    840

cccccaggtt ctcaccgaac ggcctcgggg agaggactac ggagaggtga cagcgagggc    900

ggagtgaacc ggggcatcgg accgagccgc ggcggcggca gcctgacgct gcagccagac    960

tacgccaagt acgccacgtt caaggccgcc gcgctcaagg ccgcagaggc cgccccgcgg   1020

gacttctgtc agcgtttccc cgccctcgag ccgtccccgc gtcgcccggc ccggcccgcc   1080

ccgctcagcc acccgacggc tcgggccttc caggtacccc ggcgacccgg gcacgcggcc   1140

cggcgccagt tcagtgtgaa gatgcctgag accttcaacc cgcagctccc cggcctttac   1200

ggcagcgcgg gccgcgggtc ccggtaccta aggaccaata gcaagaccga ggtcaccgtg   1260

tga                                                                 1263


<210>  4083
<211>  420
<212>  PRT
<213>  Homosapiens

<400>  4083

Met Ala Arg Ala Gly Ala Arg Gly Leu Leu Gly Gly Arg Arg Pro Pro 
1               5                   10                  15      


Gly Leu Arg Leu Ala Leu Ala Leu Arg Leu Ala Leu Leu Leu Ala Arg 
            20                  25                  30          


Pro Pro Ser Gly Arg Ala Gly Ala Pro Glu Ala Gln Gly Pro Ala Ala 
        35                  40                  45              


Pro Gly Thr Thr Ala Pro Glu Gly Gly Asp Arg Cys Arg Gly Tyr Tyr 
    50                  55                  60                  


Asp Val Met Gly Gln Trp Asp Pro Pro Phe Asn Cys Ser Ser Gly Ala 
65                  70                  75                  80  


Tyr Ser Phe Cys Cys Gly Thr Cys Gly Tyr Arg Phe Cys Cys His Asp 
                85                  90                  95      


Gly Pro Arg Arg Leu Asp Gln Ser Arg Cys Ser Asn Tyr Asp Thr Pro 
            100                 105                 110         


Ala Trp Val Gln Thr Gly Arg Pro Pro Ala Arg Ala Arg Asp Thr Ala 
        115                 120                 125             


Ala Pro Arg Asp Pro Gly Arg Glu Arg Ser His Thr Ala Val Tyr Ala 
    130                 135                 140                 


Val Cys Gly Val Ala Ala Leu Leu Val Leu Ala Gly Ile Gly Ala Arg 
145                 150                 155                 160 


Leu Gly Leu Glu Arg Ala His Ser Pro Arg Ala Arg Arg Thr Val Thr 
                165                 170                 175     


Arg Ala Leu Thr Glu Leu Leu Lys Gln Pro Gly Pro Gln Glu Pro Leu 
            180                 185                 190         


Pro Pro Thr Leu Gly Pro Pro Leu Gly Gly Cys Val Gln Val Gln Met 
        195                 200                 205             


Gly Asp Gly Leu Pro Arg Gly Ser Pro His Asn Ser Ala Gly Pro Arg 
    210                 215                 220                 


Thr Pro Arg Leu Ala Arg Ala Ser Pro Pro Gly Glu Pro Phe Met Arg 
225                 230                 235                 240 


Val Ala Pro Pro Gly Leu Ala Ala Ala Ala Ala Ala Arg Asp Ser Glu 
                245                 250                 255     


Pro Gly Pro Val Pro Gly Ala Gly Gly Cys Gly Glu Asp Arg Leu Gly 
            260                 265                 270         


Ser Gln Pro Arg Pro Glu Asn Gly Pro Pro Gly Ser His Arg Thr Ala 
        275                 280                 285             


Ser Gly Arg Gly Leu Arg Arg Gly Asp Ser Glu Gly Gly Val Asn Arg 
    290                 295                 300                 


Gly Ile Gly Pro Ser Arg Gly Gly Gly Ser Leu Thr Leu Gln Pro Asp 
305                 310                 315                 320 


Tyr Ala Lys Tyr Ala Thr Phe Lys Ala Ala Ala Leu Lys Ala Ala Glu 
                325                 330                 335     


Ala Ala Pro Arg Asp Phe Cys Gln Arg Phe Pro Ala Leu Glu Pro Ser 
            340                 345                 350         


Pro Arg Arg Pro Ala Arg Pro Ala Pro Leu Ser His Pro Thr Ala Arg 
        355                 360                 365             


Ala Phe Gln Val Pro Arg Arg Pro Gly His Ala Ala Arg Arg Gln Phe 
    370                 375                 380                 


Ser Val Lys Met Pro Glu Thr Phe Asn Pro Gln Leu Pro Gly Leu Tyr 
385                 390                 395                 400 


Gly Ser Ala Gly Arg Gly Ser Arg Tyr Leu Arg Thr Asn Ser Lys Thr 
                405                 410                 415     


Glu Val Thr Val 
            420 


<210>  4084
<211>  898
<212>  DNA
<213>  Homosapiens

<400>  4084
gcaccatgag gcgagggccc cggagcctgc ggggcaggga cgcgccagcc cccacgccct     60

gcgtcccggc cgagtgcttc gacctgctgg tccgccactg cgtggcctgc gggctcctgc    120

gcacgccgcg gccgaaaccg gccggggcca gcagccctgc gcccaggacg gcgctgcagc    180

cgcaggagtc ggtgggcgcg ggggccggcg aggcggcgct gcccctgccc gggctgctct    240

ttggcgcccc cgcgctgctg ggcctggcac tggtcctggc gctggtcctg gtgggtctgg    300

tgagctggag gcggcgacag cggcggcttc gcggcgcgtc ctccgcagag gcccccgacg    360

gagacaagga cgccccagag cccctggaca aggtcatcat tctgtctccg ggaatctctg    420

atgccacagc tcctgcctgg cctcctcctg gggaagaccc aggaaccacc ccacctggcc    480

acagtgtccc tgtgccagcc acagagctgg gctccactga actggtgacc accaagacgg    540

ccggccctga gcaacaatag cagggagccg gcaggaggtg gcccctgccc tccctctgga    600

cccccagcca ggggcttgga aatcaaattc agctcttcac tccagcatgc acatgccctc    660

tttctgggac caggctaacc tgcagaagca cagacactac agaccacagc attcagcccc    720

catggagttt ggtgtgcttg cctttggctt cagacctcac catctttgac agcccttgaa    780

ggtggtagcc cagctcctgt tcctgtgcct tcaaaaggct ggggcactat gagtaaaaga    840

ccgcttttaa aatggggaag gcaccattaa gccaaaatga atctgaaaaa agacaaaa      898


<210>  4085
<211>  184
<212>  PRT
<213>  Homosapiens

<400>  4085

Met Arg Arg Gly Pro Arg Ser Leu Arg Gly Arg Asp Ala Pro Ala Pro 
1               5                   10                  15      


Thr Pro Cys Val Pro Ala Glu Cys Phe Asp Leu Leu Val Arg His Cys 
            20                  25                  30          


Val Ala Cys Gly Leu Leu Arg Thr Pro Arg Pro Lys Pro Ala Gly Ala 
        35                  40                  45              


Ser Ser Pro Ala Pro Arg Thr Ala Leu Gln Pro Gln Glu Ser Val Gly 
    50                  55                  60                  


Ala Gly Ala Gly Glu Ala Ala Leu Pro Leu Pro Gly Leu Leu Phe Gly 
65                  70                  75                  80  


Ala Pro Ala Leu Leu Gly Leu Ala Leu Val Leu Ala Leu Val Leu Val 
                85                  90                  95      


Gly Leu Val Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser 
            100                 105                 110         


Ser Ala Glu Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp 
        115                 120                 125             


Lys Val Ile Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala 
    130                 135                 140                 


Trp Pro Pro Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser 
145                 150                 155                 160 


Val Pro Val Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr 
                165                 170                 175     


Lys Thr Ala Gly Pro Glu Gln Gln 
            180                 


<210>  4086
<211>  855
<212>  DNA
<213>  Homosapiens

<400>  4086
ggctggactc agggcggttt gaaagatcgg cgcgcaccgc aggagcaacg gttggtcctg     60

cggctgtgat gtcggtgttg aggcccctgg acaagctgcc cggcctgaac acggccacca    120

tcttgctggt gggcacggag gatgctcttc tgcagcagct ggcggactcg atgctcaaag    180

aggactgcgc ctccgagctg aaggtccact tggcaaagtc cctccctttg ccctccagtg    240

tgaatcggcc ccgaattgac ctgatcgtgt ttgtggttaa tcttcacagc aaatacagtc    300

tccagaacac agaggagtcc ctgcgccatg tggatgccag cttcttcttg gggaaggtgt    360

gtttcctcgc cacaggtggt ggaaggcttt agggccacca tggcgcagcg cctggtgcgc    420

gtgctgcaga tctgtgctgg ccacgtgccc ggtgtctcag ctctgaacct gctgtccctg    480

ctgagaagct ctgagggccc ctccctggag gacctgtgag ggtggctggc ccctgggctg    540

ccccttctca tggcttcgtg ctgactccat aaacattctc tgttgaggat gtccagtcag    600

ggcttgacag gcccaggctc agcccgccgt ggctgggaag gttccctgca gtgccagtgc    660

tgcagcaggg agagctgggc agaagcagcg agggggccca gctggcgaga ctgtagcccc    720

ctcccactcc cacactcact cttgcagagc ctgtgtcttt aagcagctgg cgtgttacat    780

ctccatttaa ggtttccttt gaacaaaagg tctgtggcta aaaaaagttt aaaaatcaaa    840

aaaaaaaaaa aaaaa                                                     855


<210>  4087
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  4087

Met Ser Val Leu Arg Pro Leu Asp Lys Leu Pro Gly Leu Asn Thr Ala 
1               5                   10                  15      


Thr Ile Leu Leu Val Gly Thr Glu Asp Ala Leu Leu Gln Gln Leu Ala 
            20                  25                  30          


Asp Ser Met Leu Lys Glu Asp Cys Ala Ser Glu Leu Lys Val His Leu 
        35                  40                  45              


Ala Lys Ser Leu Pro Leu Pro Ser Ser Val Asn Arg Pro Arg Ile Asp 
    50                  55                  60                  


Leu Ile Val Phe Val Val Asn Leu His Ser Lys Tyr Ser Leu Gln Asn 
65                  70                  75                  80  


Thr Glu Glu Ser Leu Arg His Val Asp Ala Ser Phe Phe Leu Gly Lys 
                85                  90                  95      


Val Cys Phe Leu Ala Thr Gly Gly Gly Arg Leu 
            100                 105         


<210>  4088
<211>  947
<212>  DNA
<213>  Homosapiens

<400>  4088
ggctggactc agggcggttt gaaagatcgg cgcgcaccgc aggagcaacg gttggtcctg     60

cggctgtgat gtcggtgttg aggcccctgg acaagctgcc cggcctgaac acggccacca    120

tcttgctggt gggcacggag gatgctcttc tgcagcagct ggcggactcg atgctcaaag    180

aggactgcgc ctccgagctg aaggtccact tggcaaagtc cctccctttg ccctccagtg    240

tgaatcggcc ccgaattgac ctgatcgtgt ttgtggttaa tcttcacagc aaatacagtc    300

tccagaacac agaggagtcc ctgcgccatg tggatgccag cttcttcttg gggaaggtgt    360

gtttcctcgc cacaggtgct gggcgggaga gccactgcag cattcaccgg cacaccgtgg    420

tgaagctggc ccacacctat caaagccccc tgctctactg tgacctggag gtggaaggct    480

ttagggccac catggcgcag cgcctggtgc gcgtgctgca gatctgtgct ggccacgtgc    540

ccggtgtctc agctctgaac ctgctgtccc tgctgagaag ctctgagggc ccctccctgg    600

aggacctgtg agggtggctg gcccctgggc tgccccttct catggcttcg tgctgactcc    660

ataaacattc tctgttgagg atgtccagtc agggcttgac aggcccaggc tcagcccgcc    720

gtggctggga aggttccctg cagtgccagt gctgcagcag ggagagctgg gcagaagcag    780

cgagggggcc cagctggcga gactgtagcc ccctcccact cccacactca ctcttgcaga    840

gcctgtgtct ttaagcagct ggcgtgttac atctccattt aaggtttcct ttgaacaaaa    900

ggtctgtggc taaaaaaagt ttaaaaatca aaaaaaaaaa aaaaaaa                  947


<210>  4089
<211>  180
<212>  PRT
<213>  Homosapiens

<400>  4089

Met Ser Val Leu Arg Pro Leu Asp Lys Leu Pro Gly Leu Asn Thr Ala 
1               5                   10                  15      


Thr Ile Leu Leu Val Gly Thr Glu Asp Ala Leu Leu Gln Gln Leu Ala 
            20                  25                  30          


Asp Ser Met Leu Lys Glu Asp Cys Ala Ser Glu Leu Lys Val His Leu 
        35                  40                  45              


Ala Lys Ser Leu Pro Leu Pro Ser Ser Val Asn Arg Pro Arg Ile Asp 
    50                  55                  60                  


Leu Ile Val Phe Val Val Asn Leu His Ser Lys Tyr Ser Leu Gln Asn 
65                  70                  75                  80  


Thr Glu Glu Ser Leu Arg His Val Asp Ala Ser Phe Phe Leu Gly Lys 
                85                  90                  95      


Val Cys Phe Leu Ala Thr Gly Ala Gly Arg Glu Ser His Cys Ser Ile 
            100                 105                 110         


His Arg His Thr Val Val Lys Leu Ala His Thr Tyr Gln Ser Pro Leu 
        115                 120                 125             


Leu Tyr Cys Asp Leu Glu Val Glu Gly Phe Arg Ala Thr Met Ala Gln 
    130                 135                 140                 


Arg Leu Val Arg Val Leu Gln Ile Cys Ala Gly His Val Pro Gly Val 
145                 150                 155                 160 


Ser Ala Leu Asn Leu Leu Ser Leu Leu Arg Ser Ser Glu Gly Pro Ser 
                165                 170                 175     


Leu Glu Asp Leu 
            180 


<210>  4090
<211>  4607
<212>  DNA
<213>  Homosapiens

<400>  4090
cccgcgcccc gctcagcctt gcagccccgc gcccggagca tctccctgga ggaacggaga     60

caaaggagga ttcatgtcca aagggctccc agagaccagg acggacgcag ccatgtcaga    120

gctggtgcct gagcccaggc ctaagccagc ggtgcccatg aagcccatga gcatcaactc    180

caacctgctg ggctacatcg gcatcgacac catcatcgag cagatgcgca agaagaccat    240

gaagaccggt ttcgacttca acatcatggt cgttggccag agtggactgg gcaaatcaac    300

gctggtcaac acgctcttca aatcccaagt gagccgcaag gcctccagct ggaaccggga    360

ggagaagatc cccaagacag tggagatcaa agctatcggg catgtgatag aggaaggcgg    420

tgtcaaaatg aagctgaccg tcatcgacac cccaggcttt ggagaccaaa tcaacaatga    480

aaactgctgg gagcccattg agaagtacat caatgagcag tacgagaagt tcctgaagga    540

ggaggtcaac atcgccagga agaaacgcat ccctgacact cgtgtccact gctgccttta    600

cttcatctct cccacaggac actccttgcg acctctggat cttgagttca tgaaacacct    660

cagcaaggtt gtgaacatca tccctgtcat tgctaaggct gacaccatga ccctggagga    720

gaagtctgaa ttcaagcaaa gggttcgcaa ggagcttgaa gtaaatggca ttgaattcta    780

cccccagaag gaatttgatg aggatttgga ggataagacg gagaatgaca aaatcaggca    840

ggagagcatg ccttttgctg tggtgggaag tgacaaggag taccaagtga atggcaagag    900

ggtcctcggc cgaaaaactc catgggggat catcgaagtg gaaaacctca accactgtga    960

gtttgccctg cttcgagact ttgtcatcag gacccacctc caggacctca aggaagtgac   1020

acacaacatc cactatgaga cttacagggc caagcggctc aatgacaatg gaggcctccc   1080

tccggtgagc gtggacacag aggaaagcca cgacagtaac ccatgacgac cacttctctg   1140

tgtcatcaca catacccact tcacacacac acatcccaaa taccaccacc aaccaccttc   1200

ttcctctcaa ctctgtccca caggcctgtc tggtatttgt ggagcatctt gtctgtgtgt   1260

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgacagaga gagagcgaga gagcctgtgt   1320

gtgtgcatgc aggggtgagg tattttcact gccctccctg gagagtccct tgtaagtttg   1380

gctcctccat gcctgtccat tatctgtctc ctttccttgt gtcccaaaac aaagctgttt   1440

gcctcactca ggagatctgg gggaggtttc atttaaaagt gctgggagca ggtgagccac   1500

aggcaactct tctctcggaa cctgcacaca aactggggct atagagattc tccaaggaca   1560

gatggcagtg gagctagacc tgagtagggg gcagggagtt caggacaacc ctcctgtaag   1620

ttgggggtgg tctgggggta aggctggggc ttcctgggaa aaggaaggcc atgagaaggc   1680

agagaagtag gccagagctg ggttcttgca gaaagcatca gtgcctacaa atggagctcc   1740

acccttcagt ctgtgtcgtg ttcagtgtca caaagctacc acctgtcacc agagcctact   1800

gctgctctcc actcaactgg cctctgctgc caggccactg cctgtctctg cttccgactt   1860

tgtcttcttt ctccctttcc ctccttccct catacattgc tttctctccc tctcctgcgt   1920

gtctctgaca tctctcactt ccttttagat gaatctactt taggttcatt cctatattta   1980

gcatttatgc ccagtctact tccagaaatg actttagact gcctttcaca taaaatcaca   2040

aaactacagg acagtacaaa cagattgcca gagaaatctg ggtcaaagaa aggaatagga   2100

aagaaagttt ctgtagtcaa gcacctgaac aggccctgag ctcacaggca gccaatgtaa   2160

agagggaaac acagtgagtt atgcagttcc cagtgtccag ttaaaggaag cacacatgct   2220

agtcatgtga gacaaccttt tattgggaca tcaggttcta gaactaattc taaagaagta   2280

tcagaaacaa tatacataat ttgtctttct tagtaatttg gcttcaaaga caaatttttg   2340

accacacctc cgttttctcc gtcagacttc tctcccttct aagcaggctt ctctgttgct   2400

ccatttgctt catacatact tgacctctct tttctattcc ccatcacttt tgtgctgaag   2460

ctaatcatat ttatgtctgt ctttctctac ttttccctaa ttccctctcc tcctgactcc   2520

tgtagacatt cccaatgata cccaccgtca tacatttagg cttttcttgc ctttccctga   2580

agccctgtat ttattaatgc atatatttcc cctgcttgtt gtacaagtaa gttactcttt   2640

tcctttaatc tgtaagattc atgaaattcg gggccaggga aacagtttag ccttagggaa   2700

gggaaaacac taagtgaaac tgtttacaat aacctcatac aaccttctgt cccatctcct   2760

ggttcagcct aggtgtttca ctggtcctct atgaatccca gcacttataa tcccagtctt   2820

ttatcactca ggtgctagga aaaaaaacat agactcaaga cccaagattc aatggaccag   2880

gagaaagggg ggcggtgatc aggtcaccag tgaccccaac ctatgctctc ggtctttcct   2940

ggaggctgcc aacccagccc tcatcctccc ttgctcacaa agttacaggg taggcacctg   3000

tcaggacaga acagcagcag cgctacagcc cagaggttat acatttcaac agaacaggga   3060

tccttggcta ctgtagaagc agtcctgtat ggagaccttg gaccagcagg ggaagatcta   3120

tgggcatggg aggtgggcgt tggaaaggct gagtaggaat ggtgcctggc acccctgaac   3180

catgatctga gcctccctgg agaaggtatt ttatatgtct gctgccagct gctggtctcc   3240

acaccctcaa ccgttctcaa cccccctgca gggagaaggc ctcctgggca ctgtccttcc   3300

acctgtgcca gccaccccct gccccactgc tgaatgaagg ccatttcaag cgctgcttct   3360

cactccattc ctctcagctg ttattgctgc agggccaagc cctttttagt gctgtgctcg   3420

tccagctcac caccacagcc cctctcagcc ctcagtaggt gggaggggcc agctgcctct   3480

ttaggccagt tgcatcctcc atttatccaa accactcctc tcctcccagt ggagtggggt   3540

tctgccagta cagccctact gcatcatctg cgtcagccgg tcctagccca tctgcagggt   3600

gaaagaactc atcaagagct ccttctgccc ttgtaagccc atcccagcta cttgtaacca   3660

tctctaaggg caatggcatt gctccctacc cattcatctg catgagctac tcttggcttc   3720

cttaaagggt caagaaagca atttttctgc ttactagatt cattgagatc agctgtgtga   3780

gccccaaagt gggacaaggg tgtctccttc attacttaaa gatattcatg agggtgggtc   3840

actacagatg ttggggagca agggctagga tcacttttta aaaaatcacc acttgtggct   3900

gtcccagagt gcggttgtac atcctcccca cctcataacg cagccactga ggaagagtgg   3960

ttttcctaag aagacattgc tggagttgac tttcttctgt ccaaacaaac aaacaaaaac   4020

taaacacaca cacaaacccc cagaaaccca caatatgtac acgctaagga aaaactagca   4080

cccttctgtc cactcagcaa taagagggat ctcttcccac ctaccctacc tactcctacc   4140

cccaaccccc ttccccatta atgtgagtaa tgaattagcc tgaccacagg tggtcactgt   4200

aggctaatgg aaaataccca agggagggca aagcccccca tcagatgcat gaatgtttgc   4260

gaatgttgac tgccactgcc ccacacactg tgtctttata gaattcccct ttgcccaccc   4320

tcttcctgtc tccacctgga cacaacttgc tcaaaggctg gtgacttgtg ggccattcat   4380

ctacaaccaa gtcctgatgg agcaagaggc ccacgcctag gggatgcaag aacaacccgt   4440

ttcttaaatg ttaccagtcc cagccaatct tacggtgaca ttacagttaa atttcccaat   4500

tgaaaacaag caaacagaca ctcaaactgg tcctgtaatt gttgctagac tttatgtgtt   4560

gtacaactaa acattgctgt ttgaacagta aaaaaaaaaa aaaaaaa                 4607


<210>  4091
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  4091

Met Ser Glu Leu Val Pro Glu Pro Arg Pro Lys Pro Ala Val Pro Met 
1               5                   10                  15      


Lys Pro Met Ser Ile Asn Ser Asn Leu Leu Gly Tyr Ile Gly Ile Asp 
            20                  25                  30          


Thr Ile Ile Glu Gln Met Arg Lys Lys Thr Met Lys Thr Gly Phe Asp 
        35                  40                  45              


Phe Asn Ile Met Val Val Gly Gln Ser Gly Leu Gly Lys Ser Thr Leu 
    50                  55                  60                  


Val Asn Thr Leu Phe Lys Ser Gln Val Ser Arg Lys Ala Ser Ser Trp 
65                  70                  75                  80  


Asn Arg Glu Glu Lys Ile Pro Lys Thr Val Glu Ile Lys Ala Ile Gly 
                85                  90                  95      


His Val Ile Glu Glu Gly Gly Val Lys Met Lys Leu Thr Val Ile Asp 
            100                 105                 110         


Thr Pro Gly Phe Gly Asp Gln Ile Asn Asn Glu Asn Cys Trp Glu Pro 
        115                 120                 125             


Ile Glu Lys Tyr Ile Asn Glu Gln Tyr Glu Lys Phe Leu Lys Glu Glu 
    130                 135                 140                 


Val Asn Ile Ala Arg Lys Lys Arg Ile Pro Asp Thr Arg Val His Cys 
145                 150                 155                 160 


Cys Leu Tyr Phe Ile Ser Pro Thr Gly His Ser Leu Arg Pro Leu Asp 
                165                 170                 175     


Leu Glu Phe Met Lys His Leu Ser Lys Val Val Asn Ile Ile Pro Val 
            180                 185                 190         


Ile Ala Lys Ala Asp Thr Met Thr Leu Glu Glu Lys Ser Glu Phe Lys 
        195                 200                 205             


Gln Arg Val Arg Lys Glu Leu Glu Val Asn Gly Ile Glu Phe Tyr Pro 
    210                 215                 220                 


Gln Lys Glu Phe Asp Glu Asp Leu Glu Asp Lys Thr Glu Asn Asp Lys 
225                 230                 235                 240 


Ile Arg Gln Glu Ser Met Pro Phe Ala Val Val Gly Ser Asp Lys Glu 
                245                 250                 255     


Tyr Gln Val Asn Gly Lys Arg Val Leu Gly Arg Lys Thr Pro Trp Gly 
            260                 265                 270         


Ile Ile Glu Val Glu Asn Leu Asn His Cys Glu Phe Ala Leu Leu Arg 
        275                 280                 285             


Asp Phe Val Ile Arg Thr His Leu Gln Asp Leu Lys Glu Val Thr His 
    290                 295                 300                 


Asn Ile His Tyr Glu Thr Tyr Arg Ala Lys Arg Leu Asn Asp Asn Gly 
305                 310                 315                 320 


Gly Leu Pro Pro Val Ser Val Asp Thr Glu Glu Ser His Asp Ser Asn 
                325                 330                 335     


Pro 
    


<210>  4092
<211>  2249
<212>  DNA
<213>  Homosapiens

<400>  4092
cccgcgcccc gctcagcctt gcagccccgc gcccggagca tctccctgga ggaacggaga     60

caaaggagga ttcatgtcca aagggctccc agagaccagg acggacgcag ccatgtcaga    120

gctggtgcct gagcccaggc ctaagccagc ggtgcccatg aagcccatga gcatcaactc    180

caacctgctg ggctacatcg gcatcgacac catcatcgag cagatgcgca agaagaccat    240

gaagaccggt ttcgacttca acatcatggt cgttggccag agtggactgg gcaaatcaac    300

gctggtcaac acgctcttca aatcccaagt gagccgcaag gcctccagct ggaaccggga    360

ggagaagatc cccaagacag tggagatcaa agctatcggg catgtgatag aggaaggcgg    420

tgtcaaaatg aagctgaccg tcatcgacac cccaggcttt ggagaccaaa tcaacaatga    480

aaactgctgg gagcccattg agaagtacat caatgagcag tacgagaagt tcctgaagga    540

ggaggtcaac atcgccagga agaaacgcat ccctgacact cgtgtccact gctgccttta    600

cttcatctct cccacaggac actccttgcg acctctggat cttgagttca tgaaacacct    660

cagcaaggtt gtgaacatca tccctgtcat tgctaaggct gacaccatga ccctggagga    720

gaagtctgaa ttcaagcaaa gggttcgcaa ggagcttgaa gtaaatggca ttgaattcta    780

cccccagaag gaatttgatg aggatttgga ggataagacg gagaatgaca aaatcaggca    840

ggagagcatg ccttttgctg tggtgggaag tgacaaggag taccaagtga atggcaagag    900

ggtcctcggc cgaaaaactc catgggggat catcgaagtg gaaaacctca accactgtga    960

gtttgccctg cttcgagact ttgtcatcag gacccacctc caggacctca aggaagtgac   1020

acacaacatc cactatgaga cttacagggc caagcggctc aatgacaatg gaggcctccc   1080

tccgggagaa ggcctcctgg gcactgtcct tccacctgtg ccagccaccc cctgccccac   1140

tgctgaatga aggccatttc aagcgctgct tctcactcca ttcctctcag ctgttattgc   1200

tgcagggcca agcccttttt agtgctgtgc tcgtccagct caccaccaca gcccctctca   1260

gccctcagta ggtgggaggg gccagctgcc tctttaggcc agttgcatcc tccatttatc   1320

caaaccactc ctctcctccc agtggagtgg ggttctgcca gtacagccct actgcatcat   1380

ctgcgtcagc cggtcctagc ccatctgcag ggtgaaagaa ctcatcaaga gctccttctg   1440

cccttgtaag cccatcccag ctacttgtaa ccatctctaa gggcaatggc attgctccct   1500

acccattcat ctgcatgagc tactcttggc ttccttaaag ggtcaagaaa gcaatttttc   1560

tgcttactag attcattgag atcagctgtg tgagccccaa agtgggacaa gggtgtctcc   1620

ttcattactt aaagatattc atgagggtgg gtcactacag atgttgggga gcaagggcta   1680

ggatcacttt ttaaaaaatc accacttgtg gctgtcccag agtgcggttg tacatcctcc   1740

ccacctcata acgcagccac tgaggaagag tggttttcct aagaagacat tgctggagtt   1800

gactttcttc tgtccaaaca aacaaacaaa aactaaacac acacacaaac ccccagaaac   1860

ccacaatatg tacacgctaa ggaaaaacta gcacccttct gtccactcag caataagagg   1920

gatctcttcc cacctaccct acctactcct acccccaacc cccttcccca ttaatgtgag   1980

taatgaatta gcctgaccac aggtggtcac tgtaggctaa tggaaaatac ccaagggagg   2040

gcaaagcccc ccatcagatg catgaatgtt tgcgaatgtt gactgccact gccccacaca   2100

ctgtgtcttt atagaattcc cctttgccca ccctcttcct gtctccacct ggacacaact   2160

tgctcaaagg ctggtgactt gtgggccatt catctacaac caagtcctga tggagcaaga   2220

ggcccacgcc taggggatgc aagaacaac                                     2249


<210>  4093
<211>  345
<212>  PRT
<213>  Homosapiens

<400>  4093

Met Ser Glu Leu Val Pro Glu Pro Arg Pro Lys Pro Ala Val Pro Met 
1               5                   10                  15      


Lys Pro Met Ser Ile Asn Ser Asn Leu Leu Gly Tyr Ile Gly Ile Asp 
            20                  25                  30          


Thr Ile Ile Glu Gln Met Arg Lys Lys Thr Met Lys Thr Gly Phe Asp 
        35                  40                  45              


Phe Asn Ile Met Val Val Gly Gln Ser Gly Leu Gly Lys Ser Thr Leu 
    50                  55                  60                  


Val Asn Thr Leu Phe Lys Ser Gln Val Ser Arg Lys Ala Ser Ser Trp 
65                  70                  75                  80  


Asn Arg Glu Glu Lys Ile Pro Lys Thr Val Glu Ile Lys Ala Ile Gly 
                85                  90                  95      


His Val Ile Glu Glu Gly Gly Val Lys Met Lys Leu Thr Val Ile Asp 
            100                 105                 110         


Thr Pro Gly Phe Gly Asp Gln Ile Asn Asn Glu Asn Cys Trp Glu Pro 
        115                 120                 125             


Ile Glu Lys Tyr Ile Asn Glu Gln Tyr Glu Lys Phe Leu Lys Glu Glu 
    130                 135                 140                 


Val Asn Ile Ala Arg Lys Lys Arg Ile Pro Asp Thr Arg Val His Cys 
145                 150                 155                 160 


Cys Leu Tyr Phe Ile Ser Pro Thr Gly His Ser Leu Arg Pro Leu Asp 
                165                 170                 175     


Leu Glu Phe Met Lys His Leu Ser Lys Val Val Asn Ile Ile Pro Val 
            180                 185                 190         


Ile Ala Lys Ala Asp Thr Met Thr Leu Glu Glu Lys Ser Glu Phe Lys 
        195                 200                 205             


Gln Arg Val Arg Lys Glu Leu Glu Val Asn Gly Ile Glu Phe Tyr Pro 
    210                 215                 220                 


Gln Lys Glu Phe Asp Glu Asp Leu Glu Asp Lys Thr Glu Asn Asp Lys 
225                 230                 235                 240 


Ile Arg Gln Glu Ser Met Pro Phe Ala Val Val Gly Ser Asp Lys Glu 
                245                 250                 255     


Tyr Gln Val Asn Gly Lys Arg Val Leu Gly Arg Lys Thr Pro Trp Gly 
            260                 265                 270         


Ile Ile Glu Val Glu Asn Leu Asn His Cys Glu Phe Ala Leu Leu Arg 
        275                 280                 285             


Asp Phe Val Ile Arg Thr His Leu Gln Asp Leu Lys Glu Val Thr His 
    290                 295                 300                 


Asn Ile His Tyr Glu Thr Tyr Arg Ala Lys Arg Leu Asn Asp Asn Gly 
305                 310                 315                 320 


Gly Leu Pro Pro Gly Glu Gly Leu Leu Gly Thr Val Leu Pro Pro Val 
                325                 330                 335     


Pro Ala Thr Pro Cys Pro Thr Ala Glu 
            340                 345 


<210>  4094
<211>  2267
<212>  DNA
<213>  Homosapiens

<400>  4094
atctacgggg cggcaggagg cccgaagcaa gatggcggtg aatcagagcc acaccgagaa     60

ccgccgcgga gccctcatcc ctaacggtga aagtctcttg aagcggtctc cgaatgtgga    120

gctctccttc ccacagcgat cagaaggctc aaatgtcttt agtggtagaa agacaggaac    180

attgtttctc acttcatacc gggtgatttt cataacttca tgctccatca gtgatcccat    240

gttgtctttt atgatgccat ttgatctgat gacgaacctc actgttgaac aaccagtatt    300

tgctgcaaac ttcattaagg gaactattca ggcagctcca tatggtggct gggaaggaca    360

agctactttt aaattagtct tcagaaatgg aggtgccatt gaatttgccc agttgatggt    420

gaaagctgcc tctgctgctg cccgaggatt tccacttaga accttaaatg actggttcag    480

ctctatggga atttatgtaa ttactgggga agggaatatg tgcactccac agatgccttg    540

ttcagttatt gtctatggag ccccacctgc aggatatgga gccccacctc ccggatacgg    600

agccccacct gcaggatatg gagcccaacc cgtaggaaat gaaggcccgc ctgtgggata    660

cagagcctca cctgtgcgat atggagcccc acctcttgga tacggagccc cacctgcagg    720

atatggagcc ccacctctag gatatggagc cccacctctt ggatatggaa ccccacctct    780

cggatatgga gccccacctc tcggatatgg agccccacct gcaggaaatg aaggcccgcc    840

tgcgggatac agagcctcac ctgctggatc aggagccagg cctcacgaat ctacagcagc    900

ccaggctcct gaaaacgagg cttctcttcc ctctgcctcc tcttctcagg tccattctta    960

accttctaag atgtaaacct tgaagactca ccaagcaaag aggtacccta aaattgaagt   1020

caggataagg aggacgactc aggtatgtga tcacaggctt ctcgcaggta gttgttccac   1080

cctttggaag ggcaatctta tgggggaagg tgaaacttta cttctgtgcc tagattttag   1140

aagcagaatc aactcttaaa tagctggcta aaggaagaat accattgtgg ggctaattcc   1200

ccagtaattt ggttgacatt gggttgcatt tttaaacata actttttcca cactcgcatt   1260

caaggttcct gtcttcccat cctcattcaa gaaacattta ttatgctccg tttgctaggc   1320

actaagatgc gtgctaaaaa cgtcatgttg aacacttagt tgtttgagaa agctaaattt   1380

tcaatagtaa gagtgttata aattacggtg gatccacaaa ttggagtatt atacacctgt   1440

tgaaaactat gtctagaggt agagaaagcc ttctttgagg agaccaaaac caacaaataa   1500

aagcatgata aattgactat atcaaaattt aaaacttctc tatgacagaa gttaaaagat   1560

aggcaacaga ataggaaaaa gtgattttca acatatatat taatttatag tcagaatacg   1620

tgaataacta caaatcaatt ctccccaaaa tgacagaaat atgaattgcc gaataaccaa   1680

ggcaatagca tggccagaaa acgtttgaaa agatgttcag cttgactagt gttagggaaa   1740

tgcaacctga gatgagaaaa catttttatc tccaaagatt tacaaatatt aaaactcttg   1800

atatggcact ttcacatttt aaaatatgcc tgcgagaaaa cttgcatgtg tgcacaaaga   1860

tgcatgtggg aagatttcat tatattcatt gtttctaaca gcacaaaatt agaaataacc   1920

tatatgtcca ttaataggaa atatatgaat aggctatggt atgcccatac tacgtatgca   1980

gaaatttcta agacttgttg ataaggagaa aagcaagttg tagggagcat atactatagt   2040

gattttcagc ctcatcagac tgaatgcccc attttataac aaatatttat attttataac   2100

aaacgtttat atttgtatat ttataacaaa tattttgtaa tgtctccttc acttcaatga   2160

agtttgtaga taattgcata tgattccaca ccatttcaac caaaattaat aggccataaa   2220

tgtgatagag gaaataaaag gagtttgtag taaaaaaaaa aaaaaaa                 2267


<210>  4095
<211>  309
<212>  PRT
<213>  Homosapiens

<400>  4095

Met Ala Val Asn Gln Ser His Thr Glu Asn Arg Arg Gly Ala Leu Ile 
1               5                   10                  15      


Pro Asn Gly Glu Ser Leu Leu Lys Arg Ser Pro Asn Val Glu Leu Ser 
            20                  25                  30          


Phe Pro Gln Arg Ser Glu Gly Ser Asn Val Phe Ser Gly Arg Lys Thr 
        35                  40                  45              


Gly Thr Leu Phe Leu Thr Ser Tyr Arg Val Ile Phe Ile Thr Ser Cys 
    50                  55                  60                  


Ser Ile Ser Asp Pro Met Leu Ser Phe Met Met Pro Phe Asp Leu Met 
65                  70                  75                  80  


Thr Asn Leu Thr Val Glu Gln Pro Val Phe Ala Ala Asn Phe Ile Lys 
                85                  90                  95      


Gly Thr Ile Gln Ala Ala Pro Tyr Gly Gly Trp Glu Gly Gln Ala Thr 
            100                 105                 110         


Phe Lys Leu Val Phe Arg Asn Gly Gly Ala Ile Glu Phe Ala Gln Leu 
        115                 120                 125             


Met Val Lys Ala Ala Ser Ala Ala Ala Arg Gly Phe Pro Leu Arg Thr 
    130                 135                 140                 


Leu Asn Asp Trp Phe Ser Ser Met Gly Ile Tyr Val Ile Thr Gly Glu 
145                 150                 155                 160 


Gly Asn Met Cys Thr Pro Gln Met Pro Cys Ser Val Ile Val Tyr Gly 
                165                 170                 175     


Ala Pro Pro Ala Gly Tyr Gly Ala Pro Pro Pro Gly Tyr Gly Ala Pro 
            180                 185                 190         


Pro Ala Gly Tyr Gly Ala Gln Pro Val Gly Asn Glu Gly Pro Pro Val 
        195                 200                 205             


Gly Tyr Arg Ala Ser Pro Val Arg Tyr Gly Ala Pro Pro Leu Gly Tyr 
    210                 215                 220                 


Gly Ala Pro Pro Ala Gly Tyr Gly Ala Pro Pro Leu Gly Tyr Gly Ala 
225                 230                 235                 240 


Pro Pro Leu Gly Tyr Gly Thr Pro Pro Leu Gly Tyr Gly Ala Pro Pro 
                245                 250                 255     


Leu Gly Tyr Gly Ala Pro Pro Ala Gly Asn Glu Gly Pro Pro Ala Gly 
            260                 265                 270         


Tyr Arg Ala Ser Pro Ala Gly Ser Gly Ala Arg Pro His Glu Ser Thr 
        275                 280                 285             


Ala Ala Gln Ala Pro Glu Asn Glu Ala Ser Leu Pro Ser Ala Ser Ser 
    290                 295                 300                 


Ser Gln Val His Ser 
305                 


<210>  4096
<211>  1978
<212>  DNA
<213>  Homosapiens

<400>  4096
ctgctccgga gtgacgcggg cccgggcgcg acggtctcgg cggcggcggc ggcggcgaca     60

gagcgagcgc ggcgcggggc caccatgggg gcccagctca gcacgttggg ccatatggtg    120

ctcttcccag tctggttcct gtacagtctg ctcatgaagc tgttccagcg ctccacgcca    180

gccatcaccc tcgagagccc ggacatcaag tacccgctgc ggctcatcga ccgggagatc    240

atcagccatg acacccggcg cttccgcttt gccctgccgt caccccagca catcctgggc    300

ctccctgtcg gccagcacat ctacctctcg gctcgaattg atggaaacct ggtcgtccgg    360

ccctatacac ccatctccag cgatgatgac aagggcttcg tggacctggt catcaaggtt    420

tacttcaagg acacccatcc caagtttccc gctggaggga agatgtctca gtacctggag    480

agcatgcaga ttggagacac cattgagttc cggggcccca gtgggctgct ggtctaccag    540

ggcaaaggga agttcgccat ccgacctgac aaaaagtcca accctatcat caggacagtg    600

aagtctgtgg gcatgatcgc gggagggaca ggcatcaccc cgatgctgca ggtgatccgc    660

gccatcatga aggaccctga tgaccacact gtgtgccacc tgctctttgc caaccagacc    720

gagaaggaca tcctgctgcg acctgagctg gaggaactca ggaacaaaca ttctgcacgc    780

ttcaagctct ggtacacgct ggacagagcc cctgaagcct gggactacgg ccagggcttc    840

gtgaatgagg agatgatccg ggaccacctt ccacccccag aggaggagcc gctggtgctg    900

atgtgtggcc ccccacccat gatccagtac gcctgccttc ccaacctgga ccacgtgggc    960

caccccacgg agcgctgctt cgtcttctga gggccgggca cggtcacacg gccacccgcc   1020

ccgcgcaccc cacgccctgt tcacgctcac ccagtcacct ccccacatcg cacactgggg   1080

ccccgggttc agcctggcct gcccgtgccc tggtgaatca cctggctgag cagttcccct   1140

ggagcccctt cgggagcagg gctgtgtccc agatgggcca cggctgagcc ttcagagtac   1200

gtcctgcctg gcacttactg gtccttacca gagacgccca gccccatccc tgtcctcatg   1260

acccctcgtc caccccccac acacactata aggctgaggg ctgccagcag ccccgtctgc   1320

ccaccattcc cggccgtgga ccatagtcgg gatgtcagca gacacacatg ggcagcccaa   1380

agctgcaggt gccagggccc accccagcct cgcctgtcac ccccactccc gcctcagggc   1440

caggcccagg cctcaccacc tgacgctgca tgagacattg acaccagaaa gccctcttgg   1500

gggcactgct ccctacccca gggccctggc cagccgggag cttggctctc ctctggctag   1560

agtgggaaga gggggctggc catggggccc tcccagaacc tcagcatttc cttccagccc   1620

atccaaacac tgaggcagcc ttggggaacc ccgagctggg gggttggcag cccactgcac   1680

cgcctcaggg ttttggggtc ctgggctggg gccaccatcc ctgatggcag aactcccaca   1740

accacatgta tttattcctc tgtcctaaac cgtcccctcc ttccctcacc cccagcacag   1800

ggggattctg agcagtgcct cttgtctgag ggacatatca gtgacctcga cgttgccttt   1860

agactacagt tgtgttagcc tcttgcgtat tggctttttc agagtcattt atgagcagaa   1920

aaaaaaaaag taaaactttg ctaatattaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa     1978


<210>  4097
<211>  301
<212>  PRT
<213>  Homosapiens

<400>  4097

Met Gly Ala Gln Leu Ser Thr Leu Gly His Met Val Leu Phe Pro Val 
1               5                   10                  15      


Trp Phe Leu Tyr Ser Leu Leu Met Lys Leu Phe Gln Arg Ser Thr Pro 
            20                  25                  30          


Ala Ile Thr Leu Glu Ser Pro Asp Ile Lys Tyr Pro Leu Arg Leu Ile 
        35                  40                  45              


Asp Arg Glu Ile Ile Ser His Asp Thr Arg Arg Phe Arg Phe Ala Leu 
    50                  55                  60                  


Pro Ser Pro Gln His Ile Leu Gly Leu Pro Val Gly Gln His Ile Tyr 
65                  70                  75                  80  


Leu Ser Ala Arg Ile Asp Gly Asn Leu Val Val Arg Pro Tyr Thr Pro 
                85                  90                  95      


Ile Ser Ser Asp Asp Asp Lys Gly Phe Val Asp Leu Val Ile Lys Val 
            100                 105                 110         


Tyr Phe Lys Asp Thr His Pro Lys Phe Pro Ala Gly Gly Lys Met Ser 
        115                 120                 125             


Gln Tyr Leu Glu Ser Met Gln Ile Gly Asp Thr Ile Glu Phe Arg Gly 
    130                 135                 140                 


Pro Ser Gly Leu Leu Val Tyr Gln Gly Lys Gly Lys Phe Ala Ile Arg 
145                 150                 155                 160 


Pro Asp Lys Lys Ser Asn Pro Ile Ile Arg Thr Val Lys Ser Val Gly 
                165                 170                 175     


Met Ile Ala Gly Gly Thr Gly Ile Thr Pro Met Leu Gln Val Ile Arg 
            180                 185                 190         


Ala Ile Met Lys Asp Pro Asp Asp His Thr Val Cys His Leu Leu Phe 
        195                 200                 205             


Ala Asn Gln Thr Glu Lys Asp Ile Leu Leu Arg Pro Glu Leu Glu Glu 
    210                 215                 220                 


Leu Arg Asn Lys His Ser Ala Arg Phe Lys Leu Trp Tyr Thr Leu Asp 
225                 230                 235                 240 


Arg Ala Pro Glu Ala Trp Asp Tyr Gly Gln Gly Phe Val Asn Glu Glu 
                245                 250                 255     


Met Ile Arg Asp His Leu Pro Pro Pro Glu Glu Glu Pro Leu Val Leu 
            260                 265                 270         


Met Cys Gly Pro Pro Pro Met Ile Gln Tyr Ala Cys Leu Pro Asn Leu 
        275                 280                 285             


Asp His Val Gly His Pro Thr Glu Arg Cys Phe Val Phe 
    290                 295                 300     


<210>  4098
<211>  2000
<212>  DNA
<213>  Homosapiens

<400>  4098
aggggttggc cctggagtct gccagccaca ctgggaaaac attggagctt ggtctgccat     60

cctgaactgt ggttcccctg cctcccagcc cggctgtgag tgctcagcga ccctgacagg    120

ctgacagttg ggccatatgg tgctcttccc agtctggttc ctgtacagtc tgctcatgaa    180

gctgttccag cgctccacgc cagccatcac cctcgagagc ccggacatca agtacccgct    240

gcggctcatc gaccgggaga tcatcagcca tgacacccgg cgcttccgct ttgccctgcc    300

gtcaccccag cacatcctgg gcctccctgt cggccagcac atctacctct cggctcgaat    360

tgatggaaac ctggtcgtcc ggccctatac acccatctcc agcgatgatg acaagggctt    420

cgtggacctg gtcatcaagg tttacttcaa ggacacccat cccaagtttc ccgctggagg    480

gaagatgtct cagtacctgg agagcatgca gattggagac accattgagt tccggggccc    540

cagtgggctg ctggtctacc agggcaaagg gaagttcgcc atccgacctg acaaaaagtc    600

caaccctatc atcaggacag tgaagtctgt gggcatgatc gcgggaggga caggcatcac    660

cccgatgctg caggtgatcc gcgccatcat gaaggaccct gatgaccaca ctgtgtgcca    720

cctgctcttt gccaaccaga ccgagaagga catcctgctg cgacctgagc tggaggaact    780

caggaacaaa cattctgcac gcttcaagct ctggtacacg ctggacagag cccctgaagc    840

ctgggactac ggccagggct tcgtgaatga ggagatgatc cgggaccacc ttccaccccc    900

agaggaggag ccgctggtgc tgatgtgtgg ccccccaccc atgatccagt acgcctgcct    960

tcccaacctg gaccacgtgg gccaccccac ggagcgctgc ttcgtcttct gagggccggg   1020

cacggtcaca cggccacccg ccccgcgcac cccacgccct gttcacgctc acccagtcac   1080

ctccccacat cgcacactgg ggccccgggt tcagcctggc ctgcccgtgc cctggtgaat   1140

cacctggctg agcagttccc ctggagcccc ttcgggagca gggctgtgtc ccagatgggc   1200

cacggctgag ccttcagagt acgtcctgcc tggcacttac tggtccttac cagagacgcc   1260

cagccccatc cctgtcctca tgacccctcg tccacccccc acacacacta taaggctgag   1320

ggctgccagc agccccgtct gcccaccatt cccggccgtg gaccatagtc gggatgtcag   1380

cagacacaca tgggcagccc aaagctgcag gtgccagggc ccaccccagc ctcgcctgtc   1440

acccccactc ccgcctcagg gccaggccca ggcctcacca cctgacgctg catgagacat   1500

tgacaccaga aagccctctt gggggcactg ctccctaccc cagggccctg gccagccggg   1560

agcttggctc tcctctggct agagtgggaa gagggggctg gccatggggc cctcccagaa   1620

cctcagcatt tccttccagc ccatccaaac actgaggcag ccttggggaa ccccgagctg   1680

gggggttggc agcccactgc accgcctcag ggttttgggg tcctgggctg gggccaccat   1740

ccctgatggc agaactccca caaccacatg tatttattcc tctgtcctaa accgtcccct   1800

ccttccctca cccccagcac agggggattc tgagcagtgc ctcttgtctg agggacatat   1860

cagtgacctc gacgttgcct ttagactaca gttgtgttag cctcttgcgt attggctttt   1920

tcagagtcat ttatgagcag aaaaaaaaaa agtaaaactt tgctaatatt aaaaaaaaaa   1980

aaaaaaaaaa aaaaaaaaaa                                               2000


<210>  4099
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  4099

Met Lys Leu Phe Gln Arg Ser Thr Pro Ala Ile Thr Leu Glu Ser Pro 
1               5                   10                  15      


Asp Ile Lys Tyr Pro Leu Arg Leu Ile Asp Arg Glu Ile Ile Ser His 
            20                  25                  30          


Asp Thr Arg Arg Phe Arg Phe Ala Leu Pro Ser Pro Gln His Ile Leu 
        35                  40                  45              


Gly Leu Pro Val Gly Gln His Ile Tyr Leu Ser Ala Arg Ile Asp Gly 
    50                  55                  60                  


Asn Leu Val Val Arg Pro Tyr Thr Pro Ile Ser Ser Asp Asp Asp Lys 
65                  70                  75                  80  


Gly Phe Val Asp Leu Val Ile Lys Val Tyr Phe Lys Asp Thr His Pro 
                85                  90                  95      


Lys Phe Pro Ala Gly Gly Lys Met Ser Gln Tyr Leu Glu Ser Met Gln 
            100                 105                 110         


Ile Gly Asp Thr Ile Glu Phe Arg Gly Pro Ser Gly Leu Leu Val Tyr 
        115                 120                 125             


Gln Gly Lys Gly Lys Phe Ala Ile Arg Pro Asp Lys Lys Ser Asn Pro 
    130                 135                 140                 


Ile Ile Arg Thr Val Lys Ser Val Gly Met Ile Ala Gly Gly Thr Gly 
145                 150                 155                 160 


Ile Thr Pro Met Leu Gln Val Ile Arg Ala Ile Met Lys Asp Pro Asp 
                165                 170                 175     


Asp His Thr Val Cys His Leu Leu Phe Ala Asn Gln Thr Glu Lys Asp 
            180                 185                 190         


Ile Leu Leu Arg Pro Glu Leu Glu Glu Leu Arg Asn Lys His Ser Ala 
        195                 200                 205             


Arg Phe Lys Leu Trp Tyr Thr Leu Asp Arg Ala Pro Glu Ala Trp Asp 
    210                 215                 220                 


Tyr Gly Gln Gly Phe Val Asn Glu Glu Met Ile Arg Asp His Leu Pro 
225                 230                 235                 240 


Pro Pro Glu Glu Glu Pro Leu Val Leu Met Cys Gly Pro Pro Pro Met 
                245                 250                 255     


Ile Gln Tyr Ala Cys Leu Pro Asn Leu Asp His Val Gly His Pro Thr 
            260                 265                 270         


Glu Arg Cys Phe Val Phe 
        275             


<210>  4100
<211>  2106
<212>  DNA
<213>  Homosapiens

<400>  4100
actgccctcc ggccgccgcg ccgcccgccc gccggggccc cgctgtccgc cgcccgccgc     60

cgctggagct agagatggat ttgcagccgc tgcaagtgtg tggaagggcc gtgttcgtgt    120

tggcaaagaa ggtcggctgc tgagccaggg cgtgtctccc ggaggcctgt gggctgccag    180

gatccccacc tctctgcaat gggctgccca ggctgaccag ccggttcctg ctggaagctc    240

ctggtctgat ctggggatac catgtccaag ccccccgacc tcctgctgcg gctgctccgg    300

ggcgccccaa ggcagcgggt ctgcaccctg ttcatcatcg gcttcaagtt cacgtttttc    360

gtctccatca tgatctactg gcacgttgtg ggagagccca aggagaaagg gcagctctat    420

aacctgccag cagagatccc ctgccccacc ttgacacccc ccaccccacc ctcccacggc    480

cccactccag gcaacatctt cttcctggag acttcagacc ggaccaaccc caacttcctg    540

ttcatgtgct cggtggagtc ggccgccaga actcaccccg aatcccacgt gctggtcctg    600

atgaaagggc ttccgggtgg caacgcctct ctgccccggc acctgggcat ctcacttctg    660

agctgcttcc cgaatgtcca gatgctcccg ctggacctgc gggagctgtt ccgggacaca    720

cccctggccg actggtacgc ggccgtgcag gggcgctggg agccctacct gctgcccgtg    780

ctctccgacg cctccaggat cgcactcatg tggaagttcg gcggcatcta cctggacacg    840

gacttcattg ttctcaagaa cctgcggaac ctgaccaacg tgctgggcac ccagtcccgc    900

tacgtcctca acggcgcgtt cctggccttc gagcgccggc acgagttcat ggcgctgtgc    960

atgcgggact tcgtggacca ctacaacggc tggatctggg gtcaccaggg cccgcagctg   1020

ctcacgcggg tcttcaagaa gtggtgttcc atccgcagcc tggccgagag ccgcgcctgc   1080

cgcggcgtca ccaccctgcc ccctgaggcc ttctacccca tcccctggca ggactggaag   1140

aagtactttg aggacatcaa ccccgaggag ctgccgcggc tgctcagtgc cacctatgct   1200

gtccacgtgt ggaacaagaa gagccagggc acgcggttcg aggccacgtc cagggcactg   1260

ctggcccagc tgcatgcccg ctactgcccc acgacgcacg aggccatgaa aatgtacttg   1320

tgaggggccc gccaggtcac ctccccaacc tgctcctgat ggggcactgg gccgcccttc   1380

ccggggaggc aagattgagg gcccgggaga gggaggcccg agctgccacc gggcttaggc   1440

aggctgttga ggagctgtgg gagcaggccc agtgggaggc tgtggacacc ccgaggacag   1500

tgtcctgtct cgaggcaggg ctgacacatg gtgccatagc cagcggaggg cgctcagtga   1560

gtgccccggg ccttctagac aacaggcagg aaggatgaac ctcagggcac ccccaggtgg   1620

tgcggaaagc caggcagttg ggacagaggt gcccacgagg gcagaggccg gtgctaaggg   1680

gatggggaag aagggacaag attcccagag aggagaggag gctgttggta ggaaagtggc   1740

agggctgggg gagacccagc cccaagggtc cggggcggag gatgctttgt tcttttctgg   1800

ttttggttcc tctttcgcgg ggggtggggg aggtcaacag ggactgagtg gggcagaggc   1860

ccagaagtgc cagcctgggg agccgtttgg gggcagcccc ttctgcccac cccatccttc   1920

ttcctctcca gagatgccag gggggcgtgt atgctctgcc ccttccctca gacaggggct   1980

gggtggggag gctctttagg ctcaggagaa gcattttaaa gaaaccccca ccctgccgcc   2040

cgcattataa acacaggaga ataatcaata gaataaaagt gaccgactgt caaaaaaaaa   2100

aaaaaa                                                              2106


<210>  4101
<211>  353
<212>  PRT
<213>  Homosapiens

<400>  4101

Met Ser Lys Pro Pro Asp Leu Leu Leu Arg Leu Leu Arg Gly Ala Pro 
1               5                   10                  15      


Arg Gln Arg Val Cys Thr Leu Phe Ile Ile Gly Phe Lys Phe Thr Phe 
            20                  25                  30          


Phe Val Ser Ile Met Ile Tyr Trp His Val Val Gly Glu Pro Lys Glu 
        35                  40                  45              


Lys Gly Gln Leu Tyr Asn Leu Pro Ala Glu Ile Pro Cys Pro Thr Leu 
    50                  55                  60                  


Thr Pro Pro Thr Pro Pro Ser His Gly Pro Thr Pro Gly Asn Ile Phe 
65                  70                  75                  80  


Phe Leu Glu Thr Ser Asp Arg Thr Asn Pro Asn Phe Leu Phe Met Cys 
                85                  90                  95      


Ser Val Glu Ser Ala Ala Arg Thr His Pro Glu Ser His Val Leu Val 
            100                 105                 110         


Leu Met Lys Gly Leu Pro Gly Gly Asn Ala Ser Leu Pro Arg His Leu 
        115                 120                 125             


Gly Ile Ser Leu Leu Ser Cys Phe Pro Asn Val Gln Met Leu Pro Leu 
    130                 135                 140                 


Asp Leu Arg Glu Leu Phe Arg Asp Thr Pro Leu Ala Asp Trp Tyr Ala 
145                 150                 155                 160 


Ala Val Gln Gly Arg Trp Glu Pro Tyr Leu Leu Pro Val Leu Ser Asp 
                165                 170                 175     


Ala Ser Arg Ile Ala Leu Met Trp Lys Phe Gly Gly Ile Tyr Leu Asp 
            180                 185                 190         


Thr Asp Phe Ile Val Leu Lys Asn Leu Arg Asn Leu Thr Asn Val Leu 
        195                 200                 205             


Gly Thr Gln Ser Arg Tyr Val Leu Asn Gly Ala Phe Leu Ala Phe Glu 
    210                 215                 220                 


Arg Arg His Glu Phe Met Ala Leu Cys Met Arg Asp Phe Val Asp His 
225                 230                 235                 240 


Tyr Asn Gly Trp Ile Trp Gly His Gln Gly Pro Gln Leu Leu Thr Arg 
                245                 250                 255     


Val Phe Lys Lys Trp Cys Ser Ile Arg Ser Leu Ala Glu Ser Arg Ala 
            260                 265                 270         


Cys Arg Gly Val Thr Thr Leu Pro Pro Glu Ala Phe Tyr Pro Ile Pro 
        275                 280                 285             


Trp Gln Asp Trp Lys Lys Tyr Phe Glu Asp Ile Asn Pro Glu Glu Leu 
    290                 295                 300                 


Pro Arg Leu Leu Ser Ala Thr Tyr Ala Val His Val Trp Asn Lys Lys 
305                 310                 315                 320 


Ser Gln Gly Thr Arg Phe Glu Ala Thr Ser Arg Ala Leu Leu Ala Gln 
                325                 330                 335     


Leu His Ala Arg Tyr Cys Pro Thr Thr His Glu Ala Met Lys Met Tyr 
            340                 345                 350         


Leu 
    


<210>  4102
<211>  2725
<212>  DNA
<213>  Homosapiens

<400>  4102
gttacgcgca gccccgcccc cgcggcctcg tcgctcctgc tgaggcggta gccgcttttc     60

gtcgactctt accggttggc tgggccagct gcgccgcggc tcacagctga cgatggggga    120

ccccagcaag caggacatct tgaccatctt caagcgcctc cgctcggtgc ccactaacaa    180

ggtgtgtttt gattgtggtg ccaaaaatcc cagctgggca agcataacct atggagtgtt    240

cctttgcatt gattgctcag ggtcccaccg gtcacttggt gttcacttga gttttattcg    300

atctacagag ttggattcca actggtcatg gtttcagttg cgatgcatgc aagtcggagg    360

aaacgctagt gcatcttcct tttttcatca acatgggtgt tccaccaatg acaccaatgc    420

caagtacaac agtcgtgctg ctcagctcta tagggagaaa atcaaatcgc tcgcctctca    480

agcaacacgg aagcatggca ctgatctgtg gcttgatagt tgtgtggttc cacctttgtc    540

ccctccacca aaggaggaag atttttttgc ctctcacgtt tctcctgagg tgagtgacac    600

agcgtgggca tcagcaatag cagaaccatc ttctttaaca tcaaggcctg tggaaaccac    660

tttggaaaat aatgaaggtg gacaagagca aggaccaagt gtggaaggtc ttaatgtacc    720

aacaaaggct actttagagg tatcctctat cataaaaaag aaaccaaatc aagctaaaaa    780

aggccttggg gccaaaaaag gaagtttggg agctcagaaa ctggcaaaca catgctttaa    840

tgaaattgaa aaacaagctc aagctgcgga taaaatgaag gagcaggaag acctggccaa    900

ggtggtatct aaagaagaat caattgtttc atcattacga ttagcctata aggatcttga    960

aattcaaatg aagaaagacg aaaagatgaa cattagtggc aaaaaaaatg ttgactcaga   1020

cagactcggc atgggatttg gaaattgcag aagtgttatt tcacattcag tgacttcaga   1080

tatgcagacc atagagcagg aatcacccat tatggcaaaa ccaagaaaaa agtataatga   1140

tgacagtgac gattcatatt ttacttccag ctcaaggtac tttgacgagc cagtggagtt   1200

aaggagcagt tctttctcta gctgggatga cagttcagat tcctattgga aaaaagagac   1260

cagcaaagat actgaaacag ttctgaaaac cacaggctat tcagacagac ctactgctcg   1320

ccgcaagcca gattatgagc cagttgaaaa tacagatgag gcccagaaga agtttggcaa   1380

tgtcaaggcc atttcatcag atatgtattt tggaagacaa tcccaggctg attatgagac   1440

cagggcccgc ctagagaggc tgtcggcaag ttcctccata agctcggctg atctgttcga   1500

ggagccgagg aagcagccag cagggaacta cagcctgtcc agtgtgctgc ccaacgcccc   1560

cgacatggcg cagttcaagc agggagtgag atcggttgct ggaaaactct ccgtctttgc   1620

taatggagtc gtgacttcaa ttcaggatcg ctacggttct taatactgaa gtcatgatgt   1680

gtatttcctg gagaaattcc tctttaaatg aacaagtaac cacatctcag gcggcagtga   1740

agtccagata gttttgcaga ttgttttgct actttttcat atggtatatg tttctgattt   1800

ttaatatttc ttttgagaaa ttctgagttc tgatgtagga gctttcctgt gatttctgtt   1860

tcacgttcct tcctgtcaca ccctcctttg gcgtctctgt gtatatcctt gctttatttt   1920

cttggaacct ttgatttcaa cactgagggc ctggagacct cggctcctcc tgctcctgaa   1980

ccaggaggct tcatgtgggg gaggaggaga ggtctccatg tgacacatgg gctcagggct   2040

gccagaatca gcggatgctg gatgggcctg cagaaacaac actcaccaca cacacttcct   2100

tcaaaagacc aaaagtgact ggtgtctcgt gtgacagatt gcttcattta tgtttctaca   2160

tagtaaggtg actgccaaat aatatttgaa gtcatctgtc tctttgtaaa ttattttata   2220

tgacctataa atttaaaaat gtttttcagt gagtgctttt aacaaactta agcttctgcc   2280

ctgccaaggg aattaatgtt atcttgtgaa aggtgttgct gtttgaattg atgagaaatg   2340

gaagatgaga actccctaag agttctcata ataaatcatc tcatcacaaa tcaatacggt   2400

atacagagtt aaagtggaat gaggtaagaa gatacagcta cagaaaatag ttgcgtgtat   2460

gggagaacag tcattgtaat tgggtagttt tgttaataaa tatttttaaa tcttgctttt   2520

cagaaattac cgaatgtgta taaacaaata aagaaaaata atttagctgt gttttagaca   2580

gcattagaat atattgttca gcacagtaaa atatatttga aatttgataa gccaaaaatg   2640

tggttttgaa tgaatatttt gtgaatcttt cttaaaagct caaatttgta gacttctaaa   2700

tagaataaac acttgcagca gatgg                                         2725


<210>  4103
<211>  516
<212>  PRT
<213>  Homosapiens

<400>  4103

Met Gly Asp Pro Ser Lys Gln Asp Ile Leu Thr Ile Phe Lys Arg Leu 
1               5                   10                  15      


Arg Ser Val Pro Thr Asn Lys Val Cys Phe Asp Cys Gly Ala Lys Asn 
            20                  25                  30          


Pro Ser Trp Ala Ser Ile Thr Tyr Gly Val Phe Leu Cys Ile Asp Cys 
        35                  40                  45              


Ser Gly Ser His Arg Ser Leu Gly Val His Leu Ser Phe Ile Arg Ser 
    50                  55                  60                  


Thr Glu Leu Asp Ser Asn Trp Ser Trp Phe Gln Leu Arg Cys Met Gln 
65                  70                  75                  80  


Val Gly Gly Asn Ala Ser Ala Ser Ser Phe Phe His Gln His Gly Cys 
                85                  90                  95      


Ser Thr Asn Asp Thr Asn Ala Lys Tyr Asn Ser Arg Ala Ala Gln Leu 
            100                 105                 110         


Tyr Arg Glu Lys Ile Lys Ser Leu Ala Ser Gln Ala Thr Arg Lys His 
        115                 120                 125             


Gly Thr Asp Leu Trp Leu Asp Ser Cys Val Val Pro Pro Leu Ser Pro 
    130                 135                 140                 


Pro Pro Lys Glu Glu Asp Phe Phe Ala Ser His Val Ser Pro Glu Val 
145                 150                 155                 160 


Ser Asp Thr Ala Trp Ala Ser Ala Ile Ala Glu Pro Ser Ser Leu Thr 
                165                 170                 175     


Ser Arg Pro Val Glu Thr Thr Leu Glu Asn Asn Glu Gly Gly Gln Glu 
            180                 185                 190         


Gln Gly Pro Ser Val Glu Gly Leu Asn Val Pro Thr Lys Ala Thr Leu 
        195                 200                 205             


Glu Val Ser Ser Ile Ile Lys Lys Lys Pro Asn Gln Ala Lys Lys Gly 
    210                 215                 220                 


Leu Gly Ala Lys Lys Gly Ser Leu Gly Ala Gln Lys Leu Ala Asn Thr 
225                 230                 235                 240 


Cys Phe Asn Glu Ile Glu Lys Gln Ala Gln Ala Ala Asp Lys Met Lys 
                245                 250                 255     


Glu Gln Glu Asp Leu Ala Lys Val Val Ser Lys Glu Glu Ser Ile Val 
            260                 265                 270         


Ser Ser Leu Arg Leu Ala Tyr Lys Asp Leu Glu Ile Gln Met Lys Lys 
        275                 280                 285             


Asp Glu Lys Met Asn Ile Ser Gly Lys Lys Asn Val Asp Ser Asp Arg 
    290                 295                 300                 


Leu Gly Met Gly Phe Gly Asn Cys Arg Ser Val Ile Ser His Ser Val 
305                 310                 315                 320 


Thr Ser Asp Met Gln Thr Ile Glu Gln Glu Ser Pro Ile Met Ala Lys 
                325                 330                 335     


Pro Arg Lys Lys Tyr Asn Asp Asp Ser Asp Asp Ser Tyr Phe Thr Ser 
            340                 345                 350         


Ser Ser Arg Tyr Phe Asp Glu Pro Val Glu Leu Arg Ser Ser Ser Phe 
        355                 360                 365             


Ser Ser Trp Asp Asp Ser Ser Asp Ser Tyr Trp Lys Lys Glu Thr Ser 
    370                 375                 380                 


Lys Asp Thr Glu Thr Val Leu Lys Thr Thr Gly Tyr Ser Asp Arg Pro 
385                 390                 395                 400 


Thr Ala Arg Arg Lys Pro Asp Tyr Glu Pro Val Glu Asn Thr Asp Glu 
                405                 410                 415     


Ala Gln Lys Lys Phe Gly Asn Val Lys Ala Ile Ser Ser Asp Met Tyr 
            420                 425                 430         


Phe Gly Arg Gln Ser Gln Ala Asp Tyr Glu Thr Arg Ala Arg Leu Glu 
        435                 440                 445             


Arg Leu Ser Ala Ser Ser Ser Ile Ser Ser Ala Asp Leu Phe Glu Glu 
    450                 455                 460                 


Pro Arg Lys Gln Pro Ala Gly Asn Tyr Ser Leu Ser Ser Val Leu Pro 
465                 470                 475                 480 


Asn Ala Pro Asp Met Ala Gln Phe Lys Gln Gly Val Arg Ser Val Ala 
                485                 490                 495     


Gly Lys Leu Ser Val Phe Ala Asn Gly Val Val Thr Ser Ile Gln Asp 
            500                 505                 510         


Arg Tyr Gly Ser 
        515     


<210>  4104
<211>  3255
<212>  DNA
<213>  Homosapiens

<400>  4104
accgttgcgg ccgcaggggt ctgggcaggg ctgggcagtg ctgccggagc aaaagcggta     60

gcgggagccc ggccggagct gggtctggag acgccgtggc agcctgaacg gagtgtgcga    120

cggattggga ggtttgtcta cagattttga gcgttcgaag ttgacccctg actaagtata    180

ctttgctgct ccctcagcct ttgaaaaaat gtctgtcaca tatgatgatt ccgttggagt    240

agaagtgtcc agcgacagct tctgggaggt cgggaactac aagcggactg tgaagcggat    300

cgacgatggc caccgcctgt gcagcgacct catgaactgc ctgcatgagc gggcgcgcat    360

cgagaaggcg tatgcgcagc agctcactga gtgggcccgg cgctggaggc agcttgtgga    420

gaaagggccc cagtacggga ccgtggagaa ggcctggatg gccttcatgt ccgaggcaga    480

gagggtgagc gagctgcacc tcgaggtgaa ggcctcactg atgaacgatg acttcgagaa    540

gatcaagaac tggcagaagg aagcctttca caagcagatg atgggcggct tcaaggagac    600

caaggaagct gaggacggct ttcggaaggc acagaagccc tgggccaaga agctgaaaga    660

ggtagaagca gcaaagaaag cccaccatgc agcgtgcaaa gaggagaagc tggctatctc    720

acgagaagcc aacagcaagg cagacccatc cttcaaccct gaacagctca agaaattgca    780

agacaaaata gaaaagtgca agcaagatgt tcttaagacc aaagagaagt atgagaagtc    840

cctcaaggaa ctcgaccagg gcacacccca gtacatggag aacatggagc aggtgtttga    900

gcagtgccag cagttcgagg agaaacgcct tcgcttcttc cgggaggttc tgctggaggt    960

tcagaagcac ctaaacctgt ccaatgtggc tggttacaaa gccatttacc atgacctgga   1020

gcagagcatc agagcagctg atgcagtgga ggacctgagg tggttccgag ccaatcacgg   1080

gccaggcatg gccatgaact ggccgcagtt tgaggagtgg tccgcagacc tgattcgaac   1140

cctcagccgg agagagaaga agaaggccac tgacggcttc accctgacgg gcatcaacca   1200

gacaggcgac cagtttttgc cgagtaagcc cagcagcacc cttaatgtcc cgagcaaccc   1260

cgcccagtct gcgcagtcac agtccagcta caaccccttc gaggatgagg acgacacggg   1320

cagcaccgtc agtgagaagg aggacattaa ggccaaaaat gtgagcagct acgagaagac   1380

ccagagctat cccaccgact ggtcagacga tgagtctaac aaccccttct cctccacgga   1440

tgccaatggg gactcgaatc cattcgacga cgacgccacc tcggggacgg aagtgcgagt   1500

ccgggccctg tatgactatg aggggcagga gcatgatgag ctgagcttca aggctgggga   1560

tgagctgacc aagatggagg acgaggatga gcagggctgg tgcaagggac gcttggacaa   1620

cgggcaagtt ggcctatacc cggcaaatta tgtggaggcg atccagtgat gagtcgggga   1680

caggccagcg gggggacgga ggcggcgggc ccaggagcct cagccagcca cgtgggcatc   1740

cactcctttt cctgcaagag atgatggttc cattgctctt ggcttcatgg tgttcctgga   1800

aggcagatga gctggtcatt tcgcctggga ctcggcacct ttccgagtgc agctggaggg   1860

atctgagcgc aggaagacgc agaacaacag aaatagccgc ccctccccgc ccactgtgcc   1920

tgttggccta tcatagatct ctatgttctt gactttgtct ctcctttccg agtcaatggt   1980

gggttacact gatcttgttc cactgattac tctctctgac gagtccatca cctgcaactt   2040

aaatgaacaa gcttacatcc cattttgagt gaagattttg aggtttttaa tttaaaggct   2100

gtgtacagtt atactttttt atacacctgt tcatttctac ttaaattatg gcacagattg   2160

atgcgcacca gtcttgagga aacgatctcc ctattccctt accctgttac tcagccacgc   2220

cgtgtgtagg cttagcctca ggtggcagat gtttgaggaa aggaattatg ccaggaaggt   2280

gggaccgggt tatggtcggg tttctattgg gaatgctctt tgtgcttttg ggcatctgaa   2340

tggaagcttt acatagaacc ttaggtagaa ctcccccaaa tcgccatatt taaaaattat   2400

tttcactcta ttcttgctta aaactgtact cttttgcaaa ttaacaattt tatcactgat   2460

tcagagttaa aaagaagact aacttttcaa gcaaatgcat ctgtaaagat gctttagatt   2520

agactgtcat gtctcagtgt ctatctgtat atattatttg atattcagag aatctaaagc   2580

actcgtctac tgttttaatg agatttaaca gcttttaaca gtgagtttcg tttgtaaact   2640

gcttgaagtc tgtggcattc aggcacacgt ctggctggcc ggctgggtct cctcccgggc   2700

tcagtgggcc tggggcctct ctgacgtggt gcctgctgga gggaggctcg tcgtcaccag   2760

ctgactgctg gtccggcttc tgaccggcct ttgtcctggc tccgtagcag aacactgtaa   2820

aagtgcccgc gtctttgcag tagttgcaga tttcagtcgt cgtgttactt gtgcacaaac   2880

agaagctggg tcttacccgc agcacgagtg tctcgggctg cccggagtcg cccgggagca   2940

ggtgctgcag ccagagttac gcgggggcca cgcgggccgg cgggggtggg gggaacgtgg   3000

gggaacctgt gtttcacgtg actcagcagt gcccgccgcc gtcaccagct atgcattcac   3060

tccgtttcca gtgagcagat gtcttgcttg gaaagtggac ctgtgtctgt gtctgtcctg   3120

agaacttacc agcagaaatc ctcatttctg tgctacggat ttaccaaaaa ttgtcaagtc   3180

tttttcagtt taacagttcc tttacatgtg tagtatttga ggaaaaaaat caataaacag   3240

ttgatctcgt gcata                                                    3255


<210>  4105
<211>  486
<212>  PRT
<213>  Homosapiens

<400>  4105

Met Ser Val Thr Tyr Asp Asp Ser Val Gly Val Glu Val Ser Ser Asp 
1               5                   10                  15      


Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg Ile Asp 
            20                  25                  30          


Asp Gly His Arg Leu Cys Ser Asp Leu Met Asn Cys Leu His Glu Arg 
        35                  40                  45              


Ala Arg Ile Glu Lys Ala Tyr Ala Gln Gln Leu Thr Glu Trp Ala Arg 
    50                  55                  60                  


Arg Trp Arg Gln Leu Val Glu Lys Gly Pro Gln Tyr Gly Thr Val Glu 
65                  70                  75                  80  


Lys Ala Trp Met Ala Phe Met Ser Glu Ala Glu Arg Val Ser Glu Leu 
                85                  90                  95      


His Leu Glu Val Lys Ala Ser Leu Met Asn Asp Asp Phe Glu Lys Ile 
            100                 105                 110         


Lys Asn Trp Gln Lys Glu Ala Phe His Lys Gln Met Met Gly Gly Phe 
        115                 120                 125             


Lys Glu Thr Lys Glu Ala Glu Asp Gly Phe Arg Lys Ala Gln Lys Pro 
    130                 135                 140                 


Trp Ala Lys Lys Leu Lys Glu Val Glu Ala Ala Lys Lys Ala His His 
145                 150                 155                 160 


Ala Ala Cys Lys Glu Glu Lys Leu Ala Ile Ser Arg Glu Ala Asn Ser 
                165                 170                 175     


Lys Ala Asp Pro Ser Phe Asn Pro Glu Gln Leu Lys Lys Leu Gln Asp 
            180                 185                 190         


Lys Ile Glu Lys Cys Lys Gln Asp Val Leu Lys Thr Lys Glu Lys Tyr 
        195                 200                 205             


Glu Lys Ser Leu Lys Glu Leu Asp Gln Gly Thr Pro Gln Tyr Met Glu 
    210                 215                 220                 


Asn Met Glu Gln Val Phe Glu Gln Cys Gln Gln Phe Glu Glu Lys Arg 
225                 230                 235                 240 


Leu Arg Phe Phe Arg Glu Val Leu Leu Glu Val Gln Lys His Leu Asn 
                245                 250                 255     


Leu Ser Asn Val Ala Gly Tyr Lys Ala Ile Tyr His Asp Leu Glu Gln 
            260                 265                 270         


Ser Ile Arg Ala Ala Asp Ala Val Glu Asp Leu Arg Trp Phe Arg Ala 
        275                 280                 285             


Asn His Gly Pro Gly Met Ala Met Asn Trp Pro Gln Phe Glu Glu Trp 
    290                 295                 300                 


Ser Ala Asp Leu Ile Arg Thr Leu Ser Arg Arg Glu Lys Lys Lys Ala 
305                 310                 315                 320 


Thr Asp Gly Phe Thr Leu Thr Gly Ile Asn Gln Thr Gly Asp Gln Phe 
                325                 330                 335     


Leu Pro Ser Lys Pro Ser Ser Thr Leu Asn Val Pro Ser Asn Pro Ala 
            340                 345                 350         


Gln Ser Ala Gln Ser Gln Ser Ser Tyr Asn Pro Phe Glu Asp Glu Asp 
        355                 360                 365             


Asp Thr Gly Ser Thr Val Ser Glu Lys Glu Asp Ile Lys Ala Lys Asn 
    370                 375                 380                 


Val Ser Ser Tyr Glu Lys Thr Gln Ser Tyr Pro Thr Asp Trp Ser Asp 
385                 390                 395                 400 


Asp Glu Ser Asn Asn Pro Phe Ser Ser Thr Asp Ala Asn Gly Asp Ser 
                405                 410                 415     


Asn Pro Phe Asp Asp Asp Ala Thr Ser Gly Thr Glu Val Arg Val Arg 
            420                 425                 430         


Ala Leu Tyr Asp Tyr Glu Gly Gln Glu His Asp Glu Leu Ser Phe Lys 
        435                 440                 445             


Ala Gly Asp Glu Leu Thr Lys Met Glu Asp Glu Asp Glu Gln Gly Trp 
    450                 455                 460                 


Cys Lys Gly Arg Leu Asp Asn Gly Gln Val Gly Leu Tyr Pro Ala Asn 
465                 470                 475                 480 


Tyr Val Glu Ala Ile Gln 
                485     


<210>  4106
<211>  2992
<212>  DNA
<213>  Homosapiens

<400>  4106
cagcggggcc cgcattgagc atgggcgcgg cggccgtgcg ctggcacttg tgcgtgctgc     60

tggccctggg cacacgcggg cggctggccg ggggcagcgg gctcccaggg tcagtcgacg    120

tggatgagtg ctcagagggc acagatgact gccacatcga tgccatctgt cagaacgcgc    180

ccaagtccta caaatgcctc tgcaagccag gctacaaggg ggaaggcaag cagtgtggag    240

acattgacga gtgtgagaat gactactaca atgggggctg tgtccacgag tgcatcaaca    300

tcccggggaa ctacaggtgt acctgctttg atggcttcat gctggcacac gatggacaca    360

actgcctgga tgtggacgag tgtcaggaca ataatggtgg ctgccagcag atctgcgtca    420

atgccatggg cagctacgag tgtcagtgcc acagtggctt cttccttagt gacaaccagc    480

atacctgcat ccaccgctcc aatgagggta tgaactgcat gaacaaagac catggctgtg    540

cccacatctg ccgggagacg cccaaaggtg gggtggcctg cgactgcagg cccggctttg    600

accttgccca aaaccagaag gactgcacac taacctgtaa ttatggaaac ggaggctgcc    660

agcacagctg tgaggacaca gacacaggcc ccacgtgtgg ttgccaccag aagtacgccc    720

cccactcaga cggtcgcacg tgcatcgaga cgtgcgcagt caataacgga ggctgcgacc    780

ggacatgcaa ggacacagcc actggcgtgc gatgcagctg ccccgttgga ttcacactgc    840

agccggacgg gaagacatgc aaagacatca acgagtgcct ggtcaacaac ggaggctgcg    900

accacttctg ccgcaacacc gtaggcagct tcgagtgcgg ctgccggaag ggctacaagc    960

tgctcaccga cgagcgcacc tgccaggaca tcgacgagtg ctccttcgag cggacctgtg   1020

accacatctg catcaactcc ccgggcagct tccagtgcct gtgtcaccgc ggctacatcc   1080

tctacgggac aacccactgc ggagatgtgg acgagtgcag catgagcaac gggagctgtg   1140

accagggctg cgtcaacacc aagggcagct acgagtgcgt ctgtcccccg gggaggcggc   1200

tccactggaa ccggaaggat tgcgtggaga caggcaagtg tctttctcgc gccaagacct   1260

ccccccgggc ccagctgtcc tgcagcaagg caggcggtgt ggagagctgc ttcctttcct   1320

gcccggctca cacactcttc gtgccagact cggaaaatag ctacgtcctg agctgcggag   1380

ttccagggcc gcagggcaag gcgctgcaga aacgcaacgg caccagctct ggcctcgggc   1440

ccagctgctc agatgccccc accaccccca tcaaacagaa ggcccgcttc aagatccgag   1500

atgccaagtg ccacctccgg ccccacagcc aggcacgagc aaaggagacc gccaggcagc   1560

cgctgctgga ccactgccat gtgactttcg tgaccctcaa gtgtgactcc tccaagaaga   1620

ggcgccgtgg ccgcaagtcc ccatccaagg aggtgtccca cattacagca gagtttgaga   1680

tcgagacaaa gatggaagag gcctcagaca catgcgaagc ggactgcttg cggaagcgag   1740

cagaacagag cctgcaggcc gccatcaaga ccctgcgcaa gtccatcggc cggcagcagt   1800

tctatgtcca ggtctcaggc actgagtacg aggtagccca gaggccagcc aaggcgctgg   1860

aggggcaggg ggcatgtggc gcaggccagg tgctacagga cagcaaatgc gttgcctgtg   1920

ggcctggcac ccacttcggt ggtgagctcg gccagtgtgt gccatgtatg ccaggaacat   1980

accaggacat ggaaggccag ctcagttgca caccgtgccc cagcagcgac gggcttggtc   2040

tgcctggtgc ccgcaacgtg tcggaatgtg gaggccagtg ttctccaggc ttcttctcgg   2100

ccgatggctt caagccctgc caggcctgcc ccgtgggcac gtaccagcct gagcccgggc   2160

gcaccggctg cttcccctgt ggagggggtt tgctcaccaa acacgaaggc accacctcct   2220

tccaggactg cgaggctaaa gtgcactgct cccccggcca ccactacaac accaccaccc   2280

accgctgcat ccgctgcccc gtcggcacct accagcccga gtttggccag aaccactgca   2340

tcacctgtcc gggcaacacc agcacagact tcgatggctc caccaacgtc acacactgca   2400

aaaaccagca ctgcggcggc gagcttggtg actacaccgg ctacatcgag tcccccaact   2460

accctggcga ctacccagcc aacgctgaat gcgtctggca catcgcacct cccccaaagc   2520

gcaggatcct catcgtggtc cctgagatct tcctgcccat cgaggatgag tgcggcgatg   2580

ttctggtcat gaggaagagt gcctctccca cgtccatcac cacctatgag acctgccaga   2640

cctacgagag gcccatcgcc ttcacctccc gctcccgcaa gctctggatc cagttcaaat   2700

ccaatgaagg caacagcggc aaaggcttcc aagtgcccta tgtcacctac gatgaggact   2760

accagcaact catagaggac atcgtgcgcg atgggcgcct gtacgcctcg gagaaccacc   2820

aggaaatttt gaaagacaag aagctgatca aggccctctt cgacgtgctg gcgcatcccc   2880

agaactactt caagtacaca gcccaggaat ccaaggagat gttcccacgg tccttcatca   2940

aactgctgcg ctccaaagtg tctcggttcc tgcggcccta caaataaccg gg           2992


<210>  4107
<211>  988
<212>  PRT
<213>  Homosapiens

<400>  4107

Met Gly Ala Ala Ala Val Arg Trp His Leu Cys Val Leu Leu Ala Leu 
1               5                   10                  15      


Gly Thr Arg Gly Arg Leu Ala Gly Gly Ser Gly Leu Pro Gly Ser Val 
            20                  25                  30          


Asp Val Asp Glu Cys Ser Glu Gly Thr Asp Asp Cys His Ile Asp Ala 
        35                  40                  45              


Ile Cys Gln Asn Ala Pro Lys Ser Tyr Lys Cys Leu Cys Lys Pro Gly 
    50                  55                  60                  


Tyr Lys Gly Glu Gly Lys Gln Cys Gly Asp Ile Asp Glu Cys Glu Asn 
65                  70                  75                  80  


Asp Tyr Tyr Asn Gly Gly Cys Val His Glu Cys Ile Asn Ile Pro Gly 
                85                  90                  95      


Asn Tyr Arg Cys Thr Cys Phe Asp Gly Phe Met Leu Ala His Asp Gly 
            100                 105                 110         


His Asn Cys Leu Asp Val Asp Glu Cys Gln Asp Asn Asn Gly Gly Cys 
        115                 120                 125             


Gln Gln Ile Cys Val Asn Ala Met Gly Ser Tyr Glu Cys Gln Cys His 
    130                 135                 140                 


Ser Gly Phe Phe Leu Ser Asp Asn Gln His Thr Cys Ile His Arg Ser 
145                 150                 155                 160 


Asn Glu Gly Met Asn Cys Met Asn Lys Asp His Gly Cys Ala His Ile 
                165                 170                 175     


Cys Arg Glu Thr Pro Lys Gly Gly Val Ala Cys Asp Cys Arg Pro Gly 
            180                 185                 190         


Phe Asp Leu Ala Gln Asn Gln Lys Asp Cys Thr Leu Thr Cys Asn Tyr 
        195                 200                 205             


Gly Asn Gly Gly Cys Gln His Ser Cys Glu Asp Thr Asp Thr Gly Pro 
    210                 215                 220                 


Thr Cys Gly Cys His Gln Lys Tyr Ala Pro His Ser Asp Gly Arg Thr 
225                 230                 235                 240 


Cys Ile Glu Thr Cys Ala Val Asn Asn Gly Gly Cys Asp Arg Thr Cys 
                245                 250                 255     


Lys Asp Thr Ala Thr Gly Val Arg Cys Ser Cys Pro Val Gly Phe Thr 
            260                 265                 270         


Leu Gln Pro Asp Gly Lys Thr Cys Lys Asp Ile Asn Glu Cys Leu Val 
        275                 280                 285             


Asn Asn Gly Gly Cys Asp His Phe Cys Arg Asn Thr Val Gly Ser Phe 
    290                 295                 300                 


Glu Cys Gly Cys Arg Lys Gly Tyr Lys Leu Leu Thr Asp Glu Arg Thr 
305                 310                 315                 320 


Cys Gln Asp Ile Asp Glu Cys Ser Phe Glu Arg Thr Cys Asp His Ile 
                325                 330                 335     


Cys Ile Asn Ser Pro Gly Ser Phe Gln Cys Leu Cys His Arg Gly Tyr 
            340                 345                 350         


Ile Leu Tyr Gly Thr Thr His Cys Gly Asp Val Asp Glu Cys Ser Met 
        355                 360                 365             


Ser Asn Gly Ser Cys Asp Gln Gly Cys Val Asn Thr Lys Gly Ser Tyr 
    370                 375                 380                 


Glu Cys Val Cys Pro Pro Gly Arg Arg Leu His Trp Asn Arg Lys Asp 
385                 390                 395                 400 


Cys Val Glu Thr Gly Lys Cys Leu Ser Arg Ala Lys Thr Ser Pro Arg 
                405                 410                 415     


Ala Gln Leu Ser Cys Ser Lys Ala Gly Gly Val Glu Ser Cys Phe Leu 
            420                 425                 430         


Ser Cys Pro Ala His Thr Leu Phe Val Pro Asp Ser Glu Asn Ser Tyr 
        435                 440                 445             


Val Leu Ser Cys Gly Val Pro Gly Pro Gln Gly Lys Ala Leu Gln Lys 
    450                 455                 460                 


Arg Asn Gly Thr Ser Ser Gly Leu Gly Pro Ser Cys Ser Asp Ala Pro 
465                 470                 475                 480 


Thr Thr Pro Ile Lys Gln Lys Ala Arg Phe Lys Ile Arg Asp Ala Lys 
                485                 490                 495     


Cys His Leu Arg Pro His Ser Gln Ala Arg Ala Lys Glu Thr Ala Arg 
            500                 505                 510         


Gln Pro Leu Leu Asp His Cys His Val Thr Phe Val Thr Leu Lys Cys 
        515                 520                 525             


Asp Ser Ser Lys Lys Arg Arg Arg Gly Arg Lys Ser Pro Ser Lys Glu 
    530                 535                 540                 


Val Ser His Ile Thr Ala Glu Phe Glu Ile Glu Thr Lys Met Glu Glu 
545                 550                 555                 560 


Ala Ser Asp Thr Cys Glu Ala Asp Cys Leu Arg Lys Arg Ala Glu Gln 
                565                 570                 575     


Ser Leu Gln Ala Ala Ile Lys Thr Leu Arg Lys Ser Ile Gly Arg Gln 
            580                 585                 590         


Gln Phe Tyr Val Gln Val Ser Gly Thr Glu Tyr Glu Val Ala Gln Arg 
        595                 600                 605             


Pro Ala Lys Ala Leu Glu Gly Gln Gly Ala Cys Gly Ala Gly Gln Val 
    610                 615                 620                 


Leu Gln Asp Ser Lys Cys Val Ala Cys Gly Pro Gly Thr His Phe Gly 
625                 630                 635                 640 


Gly Glu Leu Gly Gln Cys Val Pro Cys Met Pro Gly Thr Tyr Gln Asp 
                645                 650                 655     


Met Glu Gly Gln Leu Ser Cys Thr Pro Cys Pro Ser Ser Asp Gly Leu 
            660                 665                 670         


Gly Leu Pro Gly Ala Arg Asn Val Ser Glu Cys Gly Gly Gln Cys Ser 
        675                 680                 685             


Pro Gly Phe Phe Ser Ala Asp Gly Phe Lys Pro Cys Gln Ala Cys Pro 
    690                 695                 700                 


Val Gly Thr Tyr Gln Pro Glu Pro Gly Arg Thr Gly Cys Phe Pro Cys 
705                 710                 715                 720 


Gly Gly Gly Leu Leu Thr Lys His Glu Gly Thr Thr Ser Phe Gln Asp 
                725                 730                 735     


Cys Glu Ala Lys Val His Cys Ser Pro Gly His His Tyr Asn Thr Thr 
            740                 745                 750         


Thr His Arg Cys Ile Arg Cys Pro Val Gly Thr Tyr Gln Pro Glu Phe 
        755                 760                 765             


Gly Gln Asn His Cys Ile Thr Cys Pro Gly Asn Thr Ser Thr Asp Phe 
    770                 775                 780                 


Asp Gly Ser Thr Asn Val Thr His Cys Lys Asn Gln His Cys Gly Gly 
785                 790                 795                 800 


Glu Leu Gly Asp Tyr Thr Gly Tyr Ile Glu Ser Pro Asn Tyr Pro Gly 
                805                 810                 815     


Asp Tyr Pro Ala Asn Ala Glu Cys Val Trp His Ile Ala Pro Pro Pro 
            820                 825                 830         


Lys Arg Arg Ile Leu Ile Val Val Pro Glu Ile Phe Leu Pro Ile Glu 
        835                 840                 845             


Asp Glu Cys Gly Asp Val Leu Val Met Arg Lys Ser Ala Ser Pro Thr 
    850                 855                 860                 


Ser Ile Thr Thr Tyr Glu Thr Cys Gln Thr Tyr Glu Arg Pro Ile Ala 
865                 870                 875                 880 


Phe Thr Ser Arg Ser Arg Lys Leu Trp Ile Gln Phe Lys Ser Asn Glu 
                885                 890                 895     


Gly Asn Ser Gly Lys Gly Phe Gln Val Pro Tyr Val Thr Tyr Asp Glu 
            900                 905                 910         


Asp Tyr Gln Gln Leu Ile Glu Asp Ile Val Arg Asp Gly Arg Leu Tyr 
        915                 920                 925             


Ala Ser Glu Asn His Gln Glu Ile Leu Lys Asp Lys Lys Leu Ile Lys 
    930                 935                 940                 


Ala Leu Phe Asp Val Leu Ala His Pro Gln Asn Tyr Phe Lys Tyr Thr 
945                 950                 955                 960 


Ala Gln Glu Ser Lys Glu Met Phe Pro Arg Ser Phe Ile Lys Leu Leu 
                965                 970                 975     


Arg Ser Lys Val Ser Arg Phe Leu Arg Pro Tyr Lys 
            980                 985             


<210>  4108
<211>  2395
<212>  DNA
<213>  Homosapiens

<400>  4108
cggggccagt ctgtttccag gtctggcggg gggccgggct gcggtggcgg cagcggtggg     60

agatgccggg gcggccggcg gaggcccatg tggcgctcta ggtgggatgc cagcgtcctg    120

aaggcggagg ccctggccct cctcccctgc ggcctgggca tggcattctc ccagtcccac    180

gtgatggccg ctcggcggca ccagcacagc cggctcatca tcgaggtgga cgagtacagc    240

tccaacccca cccaggcctt caccttctac aacatcaacc agggccgctt ccagccaccg    300

catgtgcaga tggtggaccc ggtgcctcac gatgccccca aacctccagg ctacacccgc    360

ttcgtctgcg tctctgatac ccactcgagg acggacccca tccagatgcc gtacggcgac    420

gtgctgatcc acgctgggga cttcactgag ctggggctcc cgagcgaggt gaagaagttc    480

aacgagtggc tgggcagcct gccctacgag tacaagatcg tgatcgcagg caaccacgag    540

ctgacctttg accaggagtt catggccgac ctcatcaagc aggactttta ctacttccca    600

tctgtgtcga agctgaagcc ggagaactat gagaatgtgc agtcgctgct gaccaactgc    660

atctaccttc aggactcgga ggtcaccgtg cggggcttcc ggatctatgg ctccccatgg    720

cagccctggt tctacggctg gggcttcaac ctcccgcgag gccaagccct gctggagaaa    780

tggaacctca ttcccgaagg cgtagacatc ctgataaccc atggaccacc actgggcttc    840

ctggactggg tccccaagaa gatgcagcgg gtgggctgtg tggagctgct caacacggtg    900

cagaggcgcg tccagccgcg gttacatgtc tttggccaca tccacgaagg gtatggtgtc    960

atggcagatg ggacgaccac ctatgtgaat gcgtccgtat gcactgtgaa ctaccagccc   1020

gtgaacccgc ccatagtcat cgacctcccc acaccccgga actcctgact gctccccact   1080

gcccctgccc tgcccgcccg tgtcagctcc acaggcctgg cccggccact gttccttcca   1140

tgctgagttg cctggacgac ccatctggct gcggggactg gcctagcagg caggtcaggg   1200

ccttggaacg actctttagc cttctgtcac ctggagttgg gaccctgcgc atccccatca   1260

ggggttctgt gctcatttac tttttctgcg tgtacatcct gcgtgtacct cgttaaagga   1320

cctactaagc tcatggccct gtcatgtttg ggaaatgact aaatcttcat tcttctccct   1380

tggacgccct cctggtttgg gaagctgctg ctcttgaatg ggttttggaa gttacacaaa   1440

atctccctct aaccacgggt ctgtgtggcg gcatgcccct gggttggggt gggtgggagg   1500

attcgtgagc tgcacacaga cagtcccttt ctctcctccc aagtgaggga ggagacaggc   1560

ccaaggcgga ggccctccga gggagcattt agggacatct caggaattca gaccgcacct   1620

ggccaggccc acagctgttt gcctggcatt gttcccccct ttttcttccc ataggcattt   1680

ttgtttactt gaacaatgac ctgagtgtcc taggcattca ctcggagcct ggatgatggg   1740

ggctggttct acagaatgag ccactggcat tcgtgcccag gaccagtgag agcgttccca   1800

gtcatggggg gatgaccctt ggtcccacgg ggaacacact gctctgtaga atgcggtagc   1860

ctggatggag ggtctgcagg cttaggctgc agcaggcctg ccatgggtgt gaacccatgt   1920

ccaggcacgc accgacacac atgcacgcac gcacccctct taattgaacc aagtgggtcc   1980

tgtgtttctc ttttctgccc cgtagtgagg ttctgttcct tggtgcggct tcccttgcac   2040

cgttaggatt ctgtctggca tgcctgcagc cgaggaagcc caggaccagc cggccctgtg   2100

aattggaggg tggcacaggg accgagcggg ccccaggctc cagcagcccc accttggaca   2160

gcttcttttt cttctttgaa ttaggactgg agcgggtggg gccagggcgg tggtgggaac   2220

cggtagggcc tagatgaggg gcaggcagtc aggcagaaat gggcaagttc agggtcagat   2280

tctgtcgtta tttaatattt tgttcatcat ggactttttc tgcatttatt ttgattttta   2340

acgttgcatt aaagtagtat tatttgtcct gaaaaaaaaa aaaaaaaaaa aaaaa        2395


<210>  4109
<211>  326
<212>  PRT
<213>  Homosapiens

<400>  4109

Met Trp Arg Ser Arg Trp Asp Ala Ser Val Leu Lys Ala Glu Ala Leu 
1               5                   10                  15      


Ala Leu Leu Pro Cys Gly Leu Gly Met Ala Phe Ser Gln Ser His Val 
            20                  25                  30          


Met Ala Ala Arg Arg His Gln His Ser Arg Leu Ile Ile Glu Val Asp 
        35                  40                  45              


Glu Tyr Ser Ser Asn Pro Thr Gln Ala Phe Thr Phe Tyr Asn Ile Asn 
    50                  55                  60                  


Gln Gly Arg Phe Gln Pro Pro His Val Gln Met Val Asp Pro Val Pro 
65                  70                  75                  80  


His Asp Ala Pro Lys Pro Pro Gly Tyr Thr Arg Phe Val Cys Val Ser 
                85                  90                  95      


Asp Thr His Ser Arg Thr Asp Pro Ile Gln Met Pro Tyr Gly Asp Val 
            100                 105                 110         


Leu Ile His Ala Gly Asp Phe Thr Glu Leu Gly Leu Pro Ser Glu Val 
        115                 120                 125             


Lys Lys Phe Asn Glu Trp Leu Gly Ser Leu Pro Tyr Glu Tyr Lys Ile 
    130                 135                 140                 


Val Ile Ala Gly Asn His Glu Leu Thr Phe Asp Gln Glu Phe Met Ala 
145                 150                 155                 160 


Asp Leu Ile Lys Gln Asp Phe Tyr Tyr Phe Pro Ser Val Ser Lys Leu 
                165                 170                 175     


Lys Pro Glu Asn Tyr Glu Asn Val Gln Ser Leu Leu Thr Asn Cys Ile 
            180                 185                 190         


Tyr Leu Gln Asp Ser Glu Val Thr Val Arg Gly Phe Arg Ile Tyr Gly 
        195                 200                 205             


Ser Pro Trp Gln Pro Trp Phe Tyr Gly Trp Gly Phe Asn Leu Pro Arg 
    210                 215                 220                 


Gly Gln Ala Leu Leu Glu Lys Trp Asn Leu Ile Pro Glu Gly Val Asp 
225                 230                 235                 240 


Ile Leu Ile Thr His Gly Pro Pro Leu Gly Phe Leu Asp Trp Val Pro 
                245                 250                 255     


Lys Lys Met Gln Arg Val Gly Cys Val Glu Leu Leu Asn Thr Val Gln 
            260                 265                 270         


Arg Arg Val Gln Pro Arg Leu His Val Phe Gly His Ile His Glu Gly 
        275                 280                 285             


Tyr Gly Val Met Ala Asp Gly Thr Thr Thr Tyr Val Asn Ala Ser Val 
    290                 295                 300                 


Cys Thr Val Asn Tyr Gln Pro Val Asn Pro Pro Ile Val Ile Asp Leu 
305                 310                 315                 320 


Pro Thr Pro Arg Asn Ser 
                325     


<210>  4110
<211>  4817
<212>  DNA
<213>  Homosapiens

<400>  4110
gaccccgcgg cttggggtcc gcgcacgcgg gtgccggccc agctaggcgg agaatcgagg     60

aggggttccc gggctcatcg cagaggattg gaagggccta gattactgcc caatgacaaa    120

agtgtgggct taatgtcctc actcttcagg gagagaatgt ggactttagc atttgaactg    180

aatatttgag attgaagatt tctgaatagg atttaatgtg caaaatggcg attataccag    240

actggcttag gtcgcatcct cacacacgaa aatttacaca ttcaagaccc cattcttcac    300

cgtgtagagt atattcaagg aatggttccc caaataagtt cagatcttct tcaaccacag    360

ctgttgcaaa tccaacactg tcctccttag atgttaaacg gattttattt caaaaaatta    420

ccgacagagg ggatgagttg caaaaagcct ttcagctgct ggatactggt cagaacttga    480

ctgtgtcaaa aagtgaactg agaagaatca tcacagactt cctgatgccg ctcacacgag    540

aacagtttca ggacgtgttg gctcagatcc cccttagcac ctctggtact gtaccgtacc    600

ttgcctttct gtccaggttt ggtggaattg acctatatat aaatggtata aagaggggag    660

gtgggaatga aatgaattgc tgccgcacat taagagaact tgaaatccaa gtgggagaaa    720

aggttttcaa aaacattaag actgttatga aagcctttga gctcattgat gttaacaaga    780

ctggactggt tcgaccgcag gagctaagaa gggttctgga gaccttctgt atgaagttaa    840

gagacgagga atacgaaaag ttttcgaaac actacaacat ccacaaggat actgcagtag    900

attacaacgt gtttttgaag aatctcagca taaataacga cttgaacctt agatattgta    960

tgggaaatca agaggtctca ttggagaatc aacaagccaa aaattccaaa aaggaacgtt   1020

tgctaggttc tgcatcatct gaagatatct ggagaaacta ctccttggat gaaattgaga   1080

ggaacttttg tctacaactt tcgaagtctt atgaaaaggt tgaaaaggcc ctcagtgcag   1140

gggacccctg taaaggtggc tacgtgtctt ttaattatct aaagattgtc ctcgacactt   1200

ttgtatacca aataccaaga agaattttta tccagttaat gaaaagattt ggacttaaag   1260

ccaccactaa aatcaattgg aagcaatttc taacatcatt tcatgagcct caggggttgc   1320

aagttagcag taaaggtccc ctgacaaaaa gaaatagcat caactctaga aatgaatctc   1380

acaaggaaaa catcatcaca aagttattta gacacactga agatcactct gcgtcactga   1440

agaaagcatt actgataatc aacactaaac ccgatggacc gataacaaga gaagaatttc   1500

gatatattct aaattgcatg gctgtaaaac taagcgattc agaattcaaa gaactaatgc   1560

aaatgcttga ccctggggac actggagtgg tcaacaccag catgtttatt gatctgattg   1620

aagagaactg taggatgaga aagacatctc cctgtacaga tgctaagaca cctttcctcc   1680

tggcctggga ttcagtggaa gaaattgttc atgatacaat tactaggaac ctacaagctt   1740

tttataacat gctacgctca tatgaccttg gagacacagg gcgcattggc cgaaataatt   1800

tcaagaaaat catgcacgtc ttctgtccat ttttaacgaa tgcacatttc ataaaactct   1860

gcagtaagat tcaggacatt ggttcaggaa gaatccttta caagaaactt ttggcatgca   1920

taggaattga tggcccaccc actgtctctc cagttcttgt tccaaaggat cagctgttaa   1980

gtgaacattt acaaaaagat gaacagcagc agccagatct ttctgagaga accaagctca   2040

cggaggataa aaccaccctg accaagaaga tgaccacaga agaagtgatt gaaaaattca   2100

aaaagtgtat acagcagcag gacccggcat tcaaaaaacg atttcttgac ttcagcaagg   2160

agcctaatgg aaaaattaac gtgcatgact ttaagaaggt actggaagac actgggatgc   2220

ccatggacga tgatcagtat gccctgctga ccactaaaat aggcttcgag aaggaaggga   2280

tgagctatct tgattttgca gcaggatttg aagatcctcc aatgagaggg ccggaaacca   2340

ctccgccgca gcctccaact ccttcaaaaa gttacgtgaa cagccacttt atcaccgcag   2400

aagaatgcct gaagcttttc cctaggaggc tgaaggagtc attccgggac ccctactctg   2460

ccttctttaa aacagatgct gacagggatg gcataatcaa catgcatgac cttcacagac   2520

tgctcctgca tctactgctt aatctcaaag acgacgagtt tgagcgcttc cttggccttc   2580

ttggcttgag acttagtgtc actttaaatt ttcgggaatt tcaaaatttg tgtgagaaga   2640

gaccatggag aacagatgaa gcgcctcaaa gactcattag accaaaacag aaggttgcgg   2700

attcagaact agcttgtgag caggctcatc agtatcttgt taccaaagca aaaaacagat   2760

ggtcagactt gtctaagaat tttctagaaa ccgataatga gggcaatggc attcttcgac   2820

gccgggacat aaagaacgca ctgtacggtt ttgatattcc cctcacacca agagagtttg   2880

aaaagctttg ggcaagatac gacaccgagg gaaaagggca cattacttac caggaatttt   2940

tacagaaatt gggtattaac tattcgcctg ctgtccatcg gccctgtgca gaggattatt   3000

tcaacttcat gggtcatttt acaaagccac agcagctaca ggaagagatg aaggagctgc   3060

agcagagcac agagaaggct gtggcagcca gggataagct tatggaccgc catcaagata   3120

tcagcaaagc attcaccaaa actgatcaat ccaaaaccaa ctacatatcc atatgcaaga   3180

tgcaggaagt gctggaagaa tgtggatgtt ctcttaccga aggggagctg acccatctgc   3240

taaacagttg gggagtcagc cggcatgata atgctatcaa ttacctcgac ttcctgagag   3300

cagtggagaa cagcaagtca acaggagctc agcccaagga aaaagaagag agcatgccaa   3360

tcaattttgc aacgctgaat ccacaggagg ctgtgaggaa gatccaggaa gtagttgagt   3420

cctcccagct ggctttgtcc acggcatttt ctgcattgga taaagaggat acaggatttg   3480

taaaggctac agaattcgga caagttctta aggatttctg ttacaaacta acggacaatc   3540

agtatcatta ttttttgagg aaactaagaa ttcatctaac cccctatata aattggaaat   3600

attttctcca gaactttagc tgtttccttg aggagacagc tgatgagtgg gctgagaaaa   3660

tgcccaaagg cccgccgcct acctctccca aggccacagc cgacagagac atcctggctc   3720

gcctccacaa agcagtgact tcccattacc atgccatcac ccaggagttt gagaattttg   3780

acaccatgaa aacgaacacc atctccagag aggagtttag ggccatttgt aatcgccgcg   3840

tccaaatcct gacggacgaa cagtttgaca gactctggaa cgagatgcca gtcaatgcca   3900

aggggaggct gaaatacccg gacttcctga gcaggttcag ttccgagaca gcagccacac   3960

caatggccac tggtgactcg gccgtggccc agagagggag cagtgtccct gacgtctcgg   4020

aaggcaccag atctgccctc tcattgccca ctcaggagct gagaccaggg tcaaagtcgc   4080

agagccaccc ctgtactcca gcgagcacca ccgtgatccc gggcactcca cccttgcaga   4140

actgtgatcc catagagagc aggctccgga agagaatcca gggctgctgg cgccagctcc   4200

tgaaagaatg caaggagaag gacgtggcca gacaggggga catcaacgcc tccgatttcc   4260

tggctcttgt ggagaaattc aacctggaca taagcaaaga ggagtgtcag cagctcatta   4320

taaaatacga cttaaagagc aacgggaaat ttgcatactg tgacttcatt cagagctgtg   4380

tcctcctgct aaaagcaaag gaaagctcac tgatgcacag gatgaagatc cagaatgcac   4440

acaagatgaa agaagccggc gcggagacgc catcttttta ctctgctctg ctgcgtattc   4500

agcccaaaat tgtgcactgc tggaggccaa tgcggcgcac gttcaaaagc tatgatgagg   4560

ctggaacagg gctgctaagc gtcgcagatt tcaggacggt cctgagacag tacagcatca   4620

acctctctga ggaagagttc ttccatattc tggagtatta cgataagacg ctgtcttcaa   4680

aaatctccta caacgacttc ctccgggcat tcctccagta gacacccctg ctgtgtgccc   4740

agcgggacga cagccacagg gcctgtttca aggctaataa aatcctataa tttgggggtt   4800

aaaaaaaaaa aaaaaaa                                                  4817


<210>  4111
<211>  1501
<212>  PRT
<213>  Homosapiens

<400>  4111

Met Cys Lys Met Ala Ile Ile Pro Asp Trp Leu Arg Ser His Pro His 
1               5                   10                  15      


Thr Arg Lys Phe Thr His Ser Arg Pro His Ser Ser Pro Cys Arg Val 
            20                  25                  30          


Tyr Ser Arg Asn Gly Ser Pro Asn Lys Phe Arg Ser Ser Ser Thr Thr 
        35                  40                  45              


Ala Val Ala Asn Pro Thr Leu Ser Ser Leu Asp Val Lys Arg Ile Leu 
    50                  55                  60                  


Phe Gln Lys Ile Thr Asp Arg Gly Asp Glu Leu Gln Lys Ala Phe Gln 
65                  70                  75                  80  


Leu Leu Asp Thr Gly Gln Asn Leu Thr Val Ser Lys Ser Glu Leu Arg 
                85                  90                  95      


Arg Ile Ile Thr Asp Phe Leu Met Pro Leu Thr Arg Glu Gln Phe Gln 
            100                 105                 110         


Asp Val Leu Ala Gln Ile Pro Leu Ser Thr Ser Gly Thr Val Pro Tyr 
        115                 120                 125             


Leu Ala Phe Leu Ser Arg Phe Gly Gly Ile Asp Leu Tyr Ile Asn Gly 
    130                 135                 140                 


Ile Lys Arg Gly Gly Gly Asn Glu Met Asn Cys Cys Arg Thr Leu Arg 
145                 150                 155                 160 


Glu Leu Glu Ile Gln Val Gly Glu Lys Val Phe Lys Asn Ile Lys Thr 
                165                 170                 175     


Val Met Lys Ala Phe Glu Leu Ile Asp Val Asn Lys Thr Gly Leu Val 
            180                 185                 190         


Arg Pro Gln Glu Leu Arg Arg Val Leu Glu Thr Phe Cys Met Lys Leu 
        195                 200                 205             


Arg Asp Glu Glu Tyr Glu Lys Phe Ser Lys His Tyr Asn Ile His Lys 
    210                 215                 220                 


Asp Thr Ala Val Asp Tyr Asn Val Phe Leu Lys Asn Leu Ser Ile Asn 
225                 230                 235                 240 


Asn Asp Leu Asn Leu Arg Tyr Cys Met Gly Asn Gln Glu Val Ser Leu 
                245                 250                 255     


Glu Asn Gln Gln Ala Lys Asn Ser Lys Lys Glu Arg Leu Leu Gly Ser 
            260                 265                 270         


Ala Ser Ser Glu Asp Ile Trp Arg Asn Tyr Ser Leu Asp Glu Ile Glu 
        275                 280                 285             


Arg Asn Phe Cys Leu Gln Leu Ser Lys Ser Tyr Glu Lys Val Glu Lys 
    290                 295                 300                 


Ala Leu Ser Ala Gly Asp Pro Cys Lys Gly Gly Tyr Val Ser Phe Asn 
305                 310                 315                 320 


Tyr Leu Lys Ile Val Leu Asp Thr Phe Val Tyr Gln Ile Pro Arg Arg 
                325                 330                 335     


Ile Phe Ile Gln Leu Met Lys Arg Phe Gly Leu Lys Ala Thr Thr Lys 
            340                 345                 350         


Ile Asn Trp Lys Gln Phe Leu Thr Ser Phe His Glu Pro Gln Gly Leu 
        355                 360                 365             


Gln Val Ser Ser Lys Gly Pro Leu Thr Lys Arg Asn Ser Ile Asn Ser 
    370                 375                 380                 


Arg Asn Glu Ser His Lys Glu Asn Ile Ile Thr Lys Leu Phe Arg His 
385                 390                 395                 400 


Thr Glu Asp His Ser Ala Ser Leu Lys Lys Ala Leu Leu Ile Ile Asn 
                405                 410                 415     


Thr Lys Pro Asp Gly Pro Ile Thr Arg Glu Glu Phe Arg Tyr Ile Leu 
            420                 425                 430         


Asn Cys Met Ala Val Lys Leu Ser Asp Ser Glu Phe Lys Glu Leu Met 
        435                 440                 445             


Gln Met Leu Asp Pro Gly Asp Thr Gly Val Val Asn Thr Ser Met Phe 
    450                 455                 460                 


Ile Asp Leu Ile Glu Glu Asn Cys Arg Met Arg Lys Thr Ser Pro Cys 
465                 470                 475                 480 


Thr Asp Ala Lys Thr Pro Phe Leu Leu Ala Trp Asp Ser Val Glu Glu 
                485                 490                 495     


Ile Val His Asp Thr Ile Thr Arg Asn Leu Gln Ala Phe Tyr Asn Met 
            500                 505                 510         


Leu Arg Ser Tyr Asp Leu Gly Asp Thr Gly Arg Ile Gly Arg Asn Asn 
        515                 520                 525             


Phe Lys Lys Ile Met His Val Phe Cys Pro Phe Leu Thr Asn Ala His 
    530                 535                 540                 


Phe Ile Lys Leu Cys Ser Lys Ile Gln Asp Ile Gly Ser Gly Arg Ile 
545                 550                 555                 560 


Leu Tyr Lys Lys Leu Leu Ala Cys Ile Gly Ile Asp Gly Pro Pro Thr 
                565                 570                 575     


Val Ser Pro Val Leu Val Pro Lys Asp Gln Leu Leu Ser Glu His Leu 
            580                 585                 590         


Gln Lys Asp Glu Gln Gln Gln Pro Asp Leu Ser Glu Arg Thr Lys Leu 
        595                 600                 605             


Thr Glu Asp Lys Thr Thr Leu Thr Lys Lys Met Thr Thr Glu Glu Val 
    610                 615                 620                 


Ile Glu Lys Phe Lys Lys Cys Ile Gln Gln Gln Asp Pro Ala Phe Lys 
625                 630                 635                 640 


Lys Arg Phe Leu Asp Phe Ser Lys Glu Pro Asn Gly Lys Ile Asn Val 
                645                 650                 655     


His Asp Phe Lys Lys Val Leu Glu Asp Thr Gly Met Pro Met Asp Asp 
            660                 665                 670         


Asp Gln Tyr Ala Leu Leu Thr Thr Lys Ile Gly Phe Glu Lys Glu Gly 
        675                 680                 685             


Met Ser Tyr Leu Asp Phe Ala Ala Gly Phe Glu Asp Pro Pro Met Arg 
    690                 695                 700                 


Gly Pro Glu Thr Thr Pro Pro Gln Pro Pro Thr Pro Ser Lys Ser Tyr 
705                 710                 715                 720 


Val Asn Ser His Phe Ile Thr Ala Glu Glu Cys Leu Lys Leu Phe Pro 
                725                 730                 735     


Arg Arg Leu Lys Glu Ser Phe Arg Asp Pro Tyr Ser Ala Phe Phe Lys 
            740                 745                 750         


Thr Asp Ala Asp Arg Asp Gly Ile Ile Asn Met His Asp Leu His Arg 
        755                 760                 765             


Leu Leu Leu His Leu Leu Leu Asn Leu Lys Asp Asp Glu Phe Glu Arg 
    770                 775                 780                 


Phe Leu Gly Leu Leu Gly Leu Arg Leu Ser Val Thr Leu Asn Phe Arg 
785                 790                 795                 800 


Glu Phe Gln Asn Leu Cys Glu Lys Arg Pro Trp Arg Thr Asp Glu Ala 
                805                 810                 815     


Pro Gln Arg Leu Ile Arg Pro Lys Gln Lys Val Ala Asp Ser Glu Leu 
            820                 825                 830         


Ala Cys Glu Gln Ala His Gln Tyr Leu Val Thr Lys Ala Lys Asn Arg 
        835                 840                 845             


Trp Ser Asp Leu Ser Lys Asn Phe Leu Glu Thr Asp Asn Glu Gly Asn 
    850                 855                 860                 


Gly Ile Leu Arg Arg Arg Asp Ile Lys Asn Ala Leu Tyr Gly Phe Asp 
865                 870                 875                 880 


Ile Pro Leu Thr Pro Arg Glu Phe Glu Lys Leu Trp Ala Arg Tyr Asp 
                885                 890                 895     


Thr Glu Gly Lys Gly His Ile Thr Tyr Gln Glu Phe Leu Gln Lys Leu 
            900                 905                 910         


Gly Ile Asn Tyr Ser Pro Ala Val His Arg Pro Cys Ala Glu Asp Tyr 
        915                 920                 925             


Phe Asn Phe Met Gly His Phe Thr Lys Pro Gln Gln Leu Gln Glu Glu 
    930                 935                 940                 


Met Lys Glu Leu Gln Gln Ser Thr Glu Lys Ala Val Ala Ala Arg Asp 
945                 950                 955                 960 


Lys Leu Met Asp Arg His Gln Asp Ile Ser Lys Ala Phe Thr Lys Thr 
                965                 970                 975     


Asp Gln Ser Lys Thr Asn Tyr Ile Ser Ile Cys Lys Met Gln Glu Val 
            980                 985                 990         


Leu Glu Glu Cys Gly Cys Ser Leu  Thr Glu Gly Glu Leu  Thr His Leu 
        995                 1000                 1005             


Leu Asn  Ser Trp Gly Val Ser  Arg His Asp Asn Ala  Ile Asn Tyr 
    1010                 1015                 1020             


Leu Asp  Phe Leu Arg Ala Val  Glu Asn Ser Lys Ser  Thr Gly Ala 
    1025                 1030                 1035             


Gln Pro  Lys Glu Lys Glu Glu  Ser Met Pro Ile Asn  Phe Ala Thr 
    1040                 1045                 1050             


Leu Asn  Pro Gln Glu Ala Val  Arg Lys Ile Gln Glu  Val Val Glu 
    1055                 1060                 1065             


Ser Ser  Gln Leu Ala Leu Ser  Thr Ala Phe Ser Ala  Leu Asp Lys 
    1070                 1075                 1080             


Glu Asp  Thr Gly Phe Val Lys  Ala Thr Glu Phe Gly  Gln Val Leu 
    1085                 1090                 1095             


Lys Asp  Phe Cys Tyr Lys Leu  Thr Asp Asn Gln Tyr  His Tyr Phe 
    1100                 1105                 1110             


Leu Arg  Lys Leu Arg Ile His  Leu Thr Pro Tyr Ile  Asn Trp Lys 
    1115                 1120                 1125             


Tyr Phe  Leu Gln Asn Phe Ser  Cys Phe Leu Glu Glu  Thr Ala Asp 
    1130                 1135                 1140             


Glu Trp  Ala Glu Lys Met Pro  Lys Gly Pro Pro Pro  Thr Ser Pro 
    1145                 1150                 1155             


Lys Ala  Thr Ala Asp Arg Asp  Ile Leu Ala Arg Leu  His Lys Ala 
    1160                 1165                 1170             


Val Thr  Ser His Tyr His Ala  Ile Thr Gln Glu Phe  Glu Asn Phe 
    1175                 1180                 1185             


Asp Thr  Met Lys Thr Asn Thr  Ile Ser Arg Glu Glu  Phe Arg Ala 
    1190                 1195                 1200             


Ile Cys  Asn Arg Arg Val Gln  Ile Leu Thr Asp Glu  Gln Phe Asp 
    1205                 1210                 1215             


Arg Leu  Trp Asn Glu Met Pro  Val Asn Ala Lys Gly  Arg Leu Lys 
    1220                 1225                 1230             


Tyr Pro  Asp Phe Leu Ser Arg  Phe Ser Ser Glu Thr  Ala Ala Thr 
    1235                 1240                 1245             


Pro Met  Ala Thr Gly Asp Ser  Ala Val Ala Gln Arg  Gly Ser Ser 
    1250                 1255                 1260             


Val Pro  Asp Val Ser Glu Gly  Thr Arg Ser Ala Leu  Ser Leu Pro 
    1265                 1270                 1275             


Thr Gln  Glu Leu Arg Pro Gly  Ser Lys Ser Gln Ser  His Pro Cys 
    1280                 1285                 1290             


Thr Pro  Ala Ser Thr Thr Val  Ile Pro Gly Thr Pro  Pro Leu Gln 
    1295                 1300                 1305             


Asn Cys  Asp Pro Ile Glu Ser  Arg Leu Arg Lys Arg  Ile Gln Gly 
    1310                 1315                 1320             


Cys Trp  Arg Gln Leu Leu Lys  Glu Cys Lys Glu Lys  Asp Val Ala 
    1325                 1330                 1335             


Arg Gln  Gly Asp Ile Asn Ala  Ser Asp Phe Leu Ala  Leu Val Glu 
    1340                 1345                 1350             


Lys Phe  Asn Leu Asp Ile Ser  Lys Glu Glu Cys Gln  Gln Leu Ile 
    1355                 1360                 1365             


Ile Lys  Tyr Asp Leu Lys Ser  Asn Gly Lys Phe Ala  Tyr Cys Asp 
    1370                 1375                 1380             


Phe Ile  Gln Ser Cys Val Leu  Leu Leu Lys Ala Lys  Glu Ser Ser 
    1385                 1390                 1395             


Leu Met  His Arg Met Lys Ile  Gln Asn Ala His Lys  Met Lys Glu 
    1400                 1405                 1410             


Ala Gly  Ala Glu Thr Pro Ser  Phe Tyr Ser Ala Leu  Leu Arg Ile 
    1415                 1420                 1425             


Gln Pro  Lys Ile Val His Cys  Trp Arg Pro Met Arg  Arg Thr Phe 
    1430                 1435                 1440             


Lys Ser  Tyr Asp Glu Ala Gly  Thr Gly Leu Leu Ser  Val Ala Asp 
    1445                 1450                 1455             


Phe Arg  Thr Val Leu Arg Gln  Tyr Ser Ile Asn Leu  Ser Glu Glu 
    1460                 1465                 1470             


Glu Phe  Phe His Ile Leu Glu  Tyr Tyr Asp Lys Thr  Leu Ser Ser 
    1475                 1480                 1485             


Lys Ile  Ser Tyr Asn Asp Phe  Leu Arg Ala Phe Leu  Gln 
    1490                 1495                 1500     


<210>  4112
<211>  4459
<212>  DNA
<213>  Homosapiens

<400>  4112
gaccccgcgg cttggggtcc gcgcacgcgg gtgccggccc agctaggcgg agaatcgagg     60

aggggttccc gggctcatcg cagaggattg gaagggccta gattactgcc caatgacaaa    120

agtgtgggct taatgtcctc actcttcagg gagagaatgt ggactttagc atttgaactg    180

aatatttgag attgaagatt tctgaataat cccccttagc acctctggta ctgtaccgta    240

ccttgccttt ctgtccaggt ttggtggaat tgacctatat ataaatggta taaagagggg    300

aggtgggaat gaaatgaatt gctgccgcac attaagagaa cttgaaatcc aagtgggaga    360

aaaggttttc aaaaacatta agactgttat gaaagccttt gagctcattg atgttaacaa    420

gactggactg gttcgaccgc aggagctaag aagggttctg gagaccttct gtatgaagtt    480

aagagacgag gaatacgaaa agttttcgaa acactacaac atccacaagg atactgcagt    540

agattacaac gtgtttttga agaatctcag cataaataac gacttgaacc ttagatattg    600

tatgggaaat caagaggtct cattggagaa tcaacaagcc aaaaattcca aaaaggaacg    660

tttgctaggt tctgcatcat ctgaagatat ctggagaaac tactccttgg atgaaattga    720

gaggaacttt tgtctacaac tttcgaagtc ttatgaaaag gttgaaaagg ccctcagtgc    780

aggggacccc tgtaaaggtg gctacgtgtc ttttaattat ctaaagattg tcctcgacac    840

ttttgtatac caaataccaa gaagaatttt tatccagtta atgaaaagat ttggacttaa    900

agccaccact aaaatcaatt ggaagcaatt tctaacatca tttcatgagc ctcaggggtt    960

gcaagttagc agtaaaggtc ccctgacaaa aagaaatagc atcaactcta gaaatgaatc   1020

tcacaaggaa aacatcatca caaagttatt tagacacact gaagatcact ctgcgtcact   1080

gaagaaagca ttactgataa tcaacactaa acccgatgga ccgataacaa gagaagaatt   1140

tcgatatatt ctaaattgca tggctgtaaa actaagcgat tcagaattca aagaactaat   1200

gcaaatgctt gaccctgggg acactggagt ggtcaacacc agcatgttta ttgatctgat   1260

tgaagagaac tgtaggatga gaaagacatc tccctgtaca gatgctaaga cacctttcct   1320

cctggcctgg gattcagtgg aagaaattgt tcatgataca attactagga acctacaagc   1380

tttttataac atgctacgct catatgacct tggagacaca gggcgcattg gccgaaataa   1440

tttcaagaaa atcatgcacg tcttctgtcc atttttaacg aatgcacatt tcataaaact   1500

ctgcagtaag attcaggaca ttggttcagg aagaatcctt tacaagaaac ttttggcatg   1560

cataggaatt gatggcccac ccactgtctc tccagttctt gttccaaagg atcagctgtt   1620

aagtgaacat ttacaaaaag atgaacagca gcagccagat ctttctgaga gaaccaagct   1680

cacggaggat aaaaccaccc tgaccaagaa gatgaccaca gaagaagtga ttgaaaaatt   1740

caaaaagtgt atacagcagc aggacccggc attcaaaaaa cgatttcttg acttcagcaa   1800

ggagcctaat ggaaaaatta acgtgcatga ctttaagaag gtactggaag acactgggat   1860

gcccatggac gatgatcagt atgccctgct gaccactaaa ataggcttcg agaaggaagg   1920

gatgagctat cttgattttg cagcaggatt tgaagatcct ccaatgagag ggccggaaac   1980

cactccgccg cagcctccaa ctccttcaaa aagttacgtg aacagccact ttatcaccgc   2040

agaagaatgc ctgaagcttt tccctaggag gctgaaggag tcattccggg acccctactc   2100

tgccttcttt aaaacagatg ctgacaggga tggcataatc aacatgcatg accttcacag   2160

actgctcctg catctactgc ttaatctcaa agacgacgag tttgagcgct tccttggcct   2220

tcttggcttg agacttagtg tcactttaaa ttttcgggaa tttcaaaatt tgtgtgagaa   2280

gagaccatgg agaacagatg aagcgcctca aagactcatt agaccaaaac agaaggttgc   2340

ggattcagaa ctagcttgtg agcaggctca tcagtatctt gttaccaaag caaaaaacag   2400

atggtcagac ttgtctaaga attttctaga aaccgataat gagggcaatg gcattcttcg   2460

acgccgggac ataaagaacg cactgtacgg ttttgatatt cccctcacac caagagagtt   2520

tgaaaagctt tgggcaagat acgacaccga gggaaaaggg cacattactt accaggaatt   2580

tttacagaaa ttgggtatta actattcgcc tgctgtccat cggccctgtg cagaggatta   2640

tttcaacttc atgggtcatt ttacaaagcc acagcagcta caggaagaga tgaaggagct   2700

gcagcagagc acagagaagg ctgtggcagc cagggataag cttatggacc gccatcaaga   2760

tatcagcaaa gcattcacca aaactgatca atccaaaacc aactacatat ccatatgcaa   2820

gatgcaggaa gtgctggaag aatgtggatg ttctcttacc gaaggggagc tgacccatct   2880

gctaaacagt tggggagtca gccggcatga taatgctatc aattacctcg acttcctgag   2940

agcagtggag aacagcaagt caacaggagc tcagcccaag gaaaaagaag agagcatgcc   3000

aatcaatttt gcaacgctga atccacagga ggctgtgagg aagatccagg aagtagttga   3060

gtcctcccag ctggctttgt ccacggcatt ttctgcattg gataaagagg atacaggatt   3120

tgtaaaggct acagaattcg gacaagttct taaggatttc tgttacaaac taacggacaa   3180

tcagtatcat tattttttga ggaaactaag aattcatcta accccctata taaattggaa   3240

atattttctc cagaacttta gctgtttcct tgaggagaca gctgatgagt gggctgagaa   3300

aatgcccaaa ggcccgccgc ctacctctcc caaggccaca gccgacagag acatcctggc   3360

tcgcctccac aaagcagtga cttcccatta ccatgccatc acccaggagt ttgagaattt   3420

tgacaccatg aaaacgaaca ccatctccag agaggagttt agggccattt gtaatcgccg   3480

cgtccaaatc ctgacggacg aacagtttga cagactctgg aacgagatgc cagtcaatgc   3540

caaggggagg ctgaaatacc cggacttcct gagcaggttc agttccgaga cagcagccac   3600

accaatggcc actggtgact cggccgtggc ccagagaggg agcagtgtcc ctgacgtctc   3660

ggaaggcacc agatctgccc tctcattgcc cactcaggag ctgagaccag ggtcaaagtc   3720

gcagagccac ccctgtactc cagcgagcac caccgtgatc ccgggcactc cacccttgca   3780

gaactgtgat cccatagaga gcaggctccg gaagagaatc cagggctgct ggcgccagct   3840

cctgaaagaa tgcaaggaga aggacgtggc cagacagggg gacatcaacg cctccgattt   3900

cctggctctt gtggagaaat tcaacctgga cataagcaaa gaggagtgtc agcagctcat   3960

tataaaatac gacttaaaga gcaacgggaa atttgcatac tgtgacttca ttcagagctg   4020

tgtcctcctg ctaaaagcaa aggaaagctc actgatgcac aggatgaaga tccagaatgc   4080

acacaagatg aaagaagccg gcgcggagac gccatctttt tactctgctc tgctgcgtat   4140

tcagcccaaa attgtgcact gctggaggcc aatgcggcgc acgttcaaaa gctatgatga   4200

ggctggaaca gggctgctaa gcgtcgcaga tttcaggacg gtcctgagac agtacagcat   4260

caacctctct gaggaagagt tcttccatat tctggagtat tacgataaga cgctgtcttc   4320

aaaaatctcc tacaacgact tcctccgggc attcctccag tagacacccc tgctgtgtgc   4380

ccagcgggac gacagccaca gggcctgttt caaggctaat aaaatcctat aatttggggg   4440

ttaaaaaaaa aaaaaaaaa                                                4459


<210>  4113
<211>  1349
<212>  PRT
<213>  Homosapiens

<400>  4113

Met Asn Cys Cys Arg Thr Leu Arg Glu Leu Glu Ile Gln Val Gly Glu 
1               5                   10                  15      


Lys Val Phe Lys Asn Ile Lys Thr Val Met Lys Ala Phe Glu Leu Ile 
            20                  25                  30          


Asp Val Asn Lys Thr Gly Leu Val Arg Pro Gln Glu Leu Arg Arg Val 
        35                  40                  45              


Leu Glu Thr Phe Cys Met Lys Leu Arg Asp Glu Glu Tyr Glu Lys Phe 
    50                  55                  60                  


Ser Lys His Tyr Asn Ile His Lys Asp Thr Ala Val Asp Tyr Asn Val 
65                  70                  75                  80  


Phe Leu Lys Asn Leu Ser Ile Asn Asn Asp Leu Asn Leu Arg Tyr Cys 
                85                  90                  95      


Met Gly Asn Gln Glu Val Ser Leu Glu Asn Gln Gln Ala Lys Asn Ser 
            100                 105                 110         


Lys Lys Glu Arg Leu Leu Gly Ser Ala Ser Ser Glu Asp Ile Trp Arg 
        115                 120                 125             


Asn Tyr Ser Leu Asp Glu Ile Glu Arg Asn Phe Cys Leu Gln Leu Ser 
    130                 135                 140                 


Lys Ser Tyr Glu Lys Val Glu Lys Ala Leu Ser Ala Gly Asp Pro Cys 
145                 150                 155                 160 


Lys Gly Gly Tyr Val Ser Phe Asn Tyr Leu Lys Ile Val Leu Asp Thr 
                165                 170                 175     


Phe Val Tyr Gln Ile Pro Arg Arg Ile Phe Ile Gln Leu Met Lys Arg 
            180                 185                 190         


Phe Gly Leu Lys Ala Thr Thr Lys Ile Asn Trp Lys Gln Phe Leu Thr 
        195                 200                 205             


Ser Phe His Glu Pro Gln Gly Leu Gln Val Ser Ser Lys Gly Pro Leu 
    210                 215                 220                 


Thr Lys Arg Asn Ser Ile Asn Ser Arg Asn Glu Ser His Lys Glu Asn 
225                 230                 235                 240 


Ile Ile Thr Lys Leu Phe Arg His Thr Glu Asp His Ser Ala Ser Leu 
                245                 250                 255     


Lys Lys Ala Leu Leu Ile Ile Asn Thr Lys Pro Asp Gly Pro Ile Thr 
            260                 265                 270         


Arg Glu Glu Phe Arg Tyr Ile Leu Asn Cys Met Ala Val Lys Leu Ser 
        275                 280                 285             


Asp Ser Glu Phe Lys Glu Leu Met Gln Met Leu Asp Pro Gly Asp Thr 
    290                 295                 300                 


Gly Val Val Asn Thr Ser Met Phe Ile Asp Leu Ile Glu Glu Asn Cys 
305                 310                 315                 320 


Arg Met Arg Lys Thr Ser Pro Cys Thr Asp Ala Lys Thr Pro Phe Leu 
                325                 330                 335     


Leu Ala Trp Asp Ser Val Glu Glu Ile Val His Asp Thr Ile Thr Arg 
            340                 345                 350         


Asn Leu Gln Ala Phe Tyr Asn Met Leu Arg Ser Tyr Asp Leu Gly Asp 
        355                 360                 365             


Thr Gly Arg Ile Gly Arg Asn Asn Phe Lys Lys Ile Met His Val Phe 
    370                 375                 380                 


Cys Pro Phe Leu Thr Asn Ala His Phe Ile Lys Leu Cys Ser Lys Ile 
385                 390                 395                 400 


Gln Asp Ile Gly Ser Gly Arg Ile Leu Tyr Lys Lys Leu Leu Ala Cys 
                405                 410                 415     


Ile Gly Ile Asp Gly Pro Pro Thr Val Ser Pro Val Leu Val Pro Lys 
            420                 425                 430         


Asp Gln Leu Leu Ser Glu His Leu Gln Lys Asp Glu Gln Gln Gln Pro 
        435                 440                 445             


Asp Leu Ser Glu Arg Thr Lys Leu Thr Glu Asp Lys Thr Thr Leu Thr 
    450                 455                 460                 


Lys Lys Met Thr Thr Glu Glu Val Ile Glu Lys Phe Lys Lys Cys Ile 
465                 470                 475                 480 


Gln Gln Gln Asp Pro Ala Phe Lys Lys Arg Phe Leu Asp Phe Ser Lys 
                485                 490                 495     


Glu Pro Asn Gly Lys Ile Asn Val His Asp Phe Lys Lys Val Leu Glu 
            500                 505                 510         


Asp Thr Gly Met Pro Met Asp Asp Asp Gln Tyr Ala Leu Leu Thr Thr 
        515                 520                 525             


Lys Ile Gly Phe Glu Lys Glu Gly Met Ser Tyr Leu Asp Phe Ala Ala 
    530                 535                 540                 


Gly Phe Glu Asp Pro Pro Met Arg Gly Pro Glu Thr Thr Pro Pro Gln 
545                 550                 555                 560 


Pro Pro Thr Pro Ser Lys Ser Tyr Val Asn Ser His Phe Ile Thr Ala 
                565                 570                 575     


Glu Glu Cys Leu Lys Leu Phe Pro Arg Arg Leu Lys Glu Ser Phe Arg 
            580                 585                 590         


Asp Pro Tyr Ser Ala Phe Phe Lys Thr Asp Ala Asp Arg Asp Gly Ile 
        595                 600                 605             


Ile Asn Met His Asp Leu His Arg Leu Leu Leu His Leu Leu Leu Asn 
    610                 615                 620                 


Leu Lys Asp Asp Glu Phe Glu Arg Phe Leu Gly Leu Leu Gly Leu Arg 
625                 630                 635                 640 


Leu Ser Val Thr Leu Asn Phe Arg Glu Phe Gln Asn Leu Cys Glu Lys 
                645                 650                 655     


Arg Pro Trp Arg Thr Asp Glu Ala Pro Gln Arg Leu Ile Arg Pro Lys 
            660                 665                 670         


Gln Lys Val Ala Asp Ser Glu Leu Ala Cys Glu Gln Ala His Gln Tyr 
        675                 680                 685             


Leu Val Thr Lys Ala Lys Asn Arg Trp Ser Asp Leu Ser Lys Asn Phe 
    690                 695                 700                 


Leu Glu Thr Asp Asn Glu Gly Asn Gly Ile Leu Arg Arg Arg Asp Ile 
705                 710                 715                 720 


Lys Asn Ala Leu Tyr Gly Phe Asp Ile Pro Leu Thr Pro Arg Glu Phe 
                725                 730                 735     


Glu Lys Leu Trp Ala Arg Tyr Asp Thr Glu Gly Lys Gly His Ile Thr 
            740                 745                 750         


Tyr Gln Glu Phe Leu Gln Lys Leu Gly Ile Asn Tyr Ser Pro Ala Val 
        755                 760                 765             


His Arg Pro Cys Ala Glu Asp Tyr Phe Asn Phe Met Gly His Phe Thr 
    770                 775                 780                 


Lys Pro Gln Gln Leu Gln Glu Glu Met Lys Glu Leu Gln Gln Ser Thr 
785                 790                 795                 800 


Glu Lys Ala Val Ala Ala Arg Asp Lys Leu Met Asp Arg His Gln Asp 
                805                 810                 815     


Ile Ser Lys Ala Phe Thr Lys Thr Asp Gln Ser Lys Thr Asn Tyr Ile 
            820                 825                 830         


Ser Ile Cys Lys Met Gln Glu Val Leu Glu Glu Cys Gly Cys Ser Leu 
        835                 840                 845             


Thr Glu Gly Glu Leu Thr His Leu Leu Asn Ser Trp Gly Val Ser Arg 
    850                 855                 860                 


His Asp Asn Ala Ile Asn Tyr Leu Asp Phe Leu Arg Ala Val Glu Asn 
865                 870                 875                 880 


Ser Lys Ser Thr Gly Ala Gln Pro Lys Glu Lys Glu Glu Ser Met Pro 
                885                 890                 895     


Ile Asn Phe Ala Thr Leu Asn Pro Gln Glu Ala Val Arg Lys Ile Gln 
            900                 905                 910         


Glu Val Val Glu Ser Ser Gln Leu Ala Leu Ser Thr Ala Phe Ser Ala 
        915                 920                 925             


Leu Asp Lys Glu Asp Thr Gly Phe Val Lys Ala Thr Glu Phe Gly Gln 
    930                 935                 940                 


Val Leu Lys Asp Phe Cys Tyr Lys Leu Thr Asp Asn Gln Tyr His Tyr 
945                 950                 955                 960 


Phe Leu Arg Lys Leu Arg Ile His Leu Thr Pro Tyr Ile Asn Trp Lys 
                965                 970                 975     


Tyr Phe Leu Gln Asn Phe Ser Cys Phe Leu Glu Glu Thr Ala Asp Glu 
            980                 985                 990         


Trp Ala Glu Lys Met Pro Lys Gly  Pro Pro Pro Thr Ser  Pro Lys Ala 
        995                 1000                 1005             


Thr Ala  Asp Arg Asp Ile Leu  Ala Arg Leu His Lys  Ala Val Thr 
    1010                 1015                 1020             


Ser His  Tyr His Ala Ile Thr  Gln Glu Phe Glu Asn  Phe Asp Thr 
    1025                 1030                 1035             


Met Lys  Thr Asn Thr Ile Ser  Arg Glu Glu Phe Arg  Ala Ile Cys 
    1040                 1045                 1050             


Asn Arg  Arg Val Gln Ile Leu  Thr Asp Glu Gln Phe  Asp Arg Leu 
    1055                 1060                 1065             


Trp Asn  Glu Met Pro Val Asn  Ala Lys Gly Arg Leu  Lys Tyr Pro 
    1070                 1075                 1080             


Asp Phe  Leu Ser Arg Phe Ser  Ser Glu Thr Ala Ala  Thr Pro Met 
    1085                 1090                 1095             


Ala Thr  Gly Asp Ser Ala Val  Ala Gln Arg Gly Ser  Ser Val Pro 
    1100                 1105                 1110             


Asp Val  Ser Glu Gly Thr Arg  Ser Ala Leu Ser Leu  Pro Thr Gln 
    1115                 1120                 1125             


Glu Leu  Arg Pro Gly Ser Lys  Ser Gln Ser His Pro  Cys Thr Pro 
    1130                 1135                 1140             


Ala Ser  Thr Thr Val Ile Pro  Gly Thr Pro Pro Leu  Gln Asn Cys 
    1145                 1150                 1155             


Asp Pro  Ile Glu Ser Arg Leu  Arg Lys Arg Ile Gln  Gly Cys Trp 
    1160                 1165                 1170             


Arg Gln  Leu Leu Lys Glu Cys  Lys Glu Lys Asp Val  Ala Arg Gln 
    1175                 1180                 1185             


Gly Asp  Ile Asn Ala Ser Asp  Phe Leu Ala Leu Val  Glu Lys Phe 
    1190                 1195                 1200             


Asn Leu  Asp Ile Ser Lys Glu  Glu Cys Gln Gln Leu  Ile Ile Lys 
    1205                 1210                 1215             


Tyr Asp  Leu Lys Ser Asn Gly  Lys Phe Ala Tyr Cys  Asp Phe Ile 
    1220                 1225                 1230             


Gln Ser  Cys Val Leu Leu Leu  Lys Ala Lys Glu Ser  Ser Leu Met 
    1235                 1240                 1245             


His Arg  Met Lys Ile Gln Asn  Ala His Lys Met Lys  Glu Ala Gly 
    1250                 1255                 1260             


Ala Glu  Thr Pro Ser Phe Tyr  Ser Ala Leu Leu Arg  Ile Gln Pro 
    1265                 1270                 1275             


Lys Ile  Val His Cys Trp Arg  Pro Met Arg Arg Thr  Phe Lys Ser 
    1280                 1285                 1290             


Tyr Asp  Glu Ala Gly Thr Gly  Leu Leu Ser Val Ala  Asp Phe Arg 
    1295                 1300                 1305             


Thr Val  Leu Arg Gln Tyr Ser  Ile Asn Leu Ser Glu  Glu Glu Phe 
    1310                 1315                 1320             


Phe His  Ile Leu Glu Tyr Tyr  Asp Lys Thr Leu Ser  Ser Lys Ile 
    1325                 1330                 1335             


Ser Tyr  Asn Asp Phe Leu Arg  Ala Phe Leu Gln 
    1340                 1345                 


<210>  4114
<211>  1689
<212>  DNA
<213>  Homosapiens

<400>  4114
atgacaagaa acgccagacc caacattgtc ctgctgatgg cagatgacct tggagtgggg     60

gatttgtgct gctacggtaa taactcagtg agcacaccta atattgaccg cctggcaagt    120

gaaggagtga ggcttaccca gcatctcgca gctgcttcca tgtgcacccc aagtcgggct    180

gccttcctga ccggccggta ccccatcaga tcagggatgg tgtctgccta caacctgaac    240

cgtgccttca cgtggcttgg tgggtcaggt ggtcttccca ccaatgaaac gacttttgcc    300

aagctgctgc agcaccgtgg ctaccgcacg ggactcatag gcaaatggca cctgggtttg    360

agctgcgcct ctcggaatga tcactgttac cacccgctca accatggttt tcactacttt    420

tacggggtgc cttttggact tttaagcgac tgccaggcat ccaagacacc agaactgcac    480

cgctggctca ggatcaaact gtggatctcc acggtagccc ttgccctggt tccttttctg    540

cttctcattc ccaagttcgc ccgctggttc tcagtgccat ggaaggtcat ctttgtcttt    600

gctctcctcg cctttctgtt tttcacttcc tggtactcta gttatggatt tactcgacgt    660

tggaattgca tccttatgag gaaccatgaa attatccagc agccaatgaa agaggagaaa    720

gtagcttccc tcatgctgaa ggaggcactt gctttcattg aaaggtacaa aagggaacct    780

tttctcctct ttttttcctt cctgcacgta catactccac tcatctccaa aaagaagttt    840

gttgggcgca gtaaatatgg caggtatggg gacaatgtag aagaaatgga ttggatggtg    900

ggtaaaatcc tggatgccct ggaccaggag cgcctggcca accacacctt ggtgtacttc    960

acctctgaca acgggggcca cctggagccc ctggacgggg ctgttcagct gggtggctgg   1020

aacgggatct acaaaggtgg caaaggaatg ggaggatggg aaggaggtat ccgtgtgcca   1080

gggatattcc ggtggccgtc agtcttggag gctgggagag tgatcaatga gcccaccagc   1140

ttaatggaca tctatccgac gctgtcttat ataggcggag ggatcttgtc ccaggacaga   1200

gtgattgacg gccagaacct aatgcccctg ctggaaggaa gggcgtccca ctccgaccac   1260

gagttcctct tccactactg tggggtctat ctgcacacgg tcaggtggca tcagaaggac   1320

tgtgcaactg tgtggaaagc tcattatgtg actcctaaat tctaccctga aggaacaggt   1380

gcctgctatg ggagtggaat atgttcatgt tcgggggatg taacctacca cgacccacca   1440

ctcctctttg acatctcaag agacccttca gaagcccttc cactgaaccc tgacaatgag   1500

ccattatttg actccgtgat caaaaagatg gaggcagcca taagagagca tcgtaggaca   1560

ctaacacctg tcccacagca gttctctgtg ttcaacacaa tttggaaacc atggctgcag   1620

ccttgctgtg ggaccttccc cttctgtggg tgtgacaagg aagatgacat ccttcccatg   1680

gctccctga                                                           1689


<210>  4115
<211>  562
<212>  PRT
<213>  Homosapiens

<400>  4115

Met Thr Arg Asn Ala Arg Pro Asn Ile Val Leu Leu Met Ala Asp Asp 
1               5                   10                  15      


Leu Gly Val Gly Asp Leu Cys Cys Tyr Gly Asn Asn Ser Val Ser Thr 
            20                  25                  30          


Pro Asn Ile Asp Arg Leu Ala Ser Glu Gly Val Arg Leu Thr Gln His 
        35                  40                  45              


Leu Ala Ala Ala Ser Met Cys Thr Pro Ser Arg Ala Ala Phe Leu Thr 
    50                  55                  60                  


Gly Arg Tyr Pro Ile Arg Ser Gly Met Val Ser Ala Tyr Asn Leu Asn 
65                  70                  75                  80  


Arg Ala Phe Thr Trp Leu Gly Gly Ser Gly Gly Leu Pro Thr Asn Glu 
                85                  90                  95      


Thr Thr Phe Ala Lys Leu Leu Gln His Arg Gly Tyr Arg Thr Gly Leu 
            100                 105                 110         


Ile Gly Lys Trp His Leu Gly Leu Ser Cys Ala Ser Arg Asn Asp His 
        115                 120                 125             


Cys Tyr His Pro Leu Asn His Gly Phe His Tyr Phe Tyr Gly Val Pro 
    130                 135                 140                 


Phe Gly Leu Leu Ser Asp Cys Gln Ala Ser Lys Thr Pro Glu Leu His 
145                 150                 155                 160 


Arg Trp Leu Arg Ile Lys Leu Trp Ile Ser Thr Val Ala Leu Ala Leu 
                165                 170                 175     


Val Pro Phe Leu Leu Leu Ile Pro Lys Phe Ala Arg Trp Phe Ser Val 
            180                 185                 190         


Pro Trp Lys Val Ile Phe Val Phe Ala Leu Leu Ala Phe Leu Phe Phe 
        195                 200                 205             


Thr Ser Trp Tyr Ser Ser Tyr Gly Phe Thr Arg Arg Trp Asn Cys Ile 
    210                 215                 220                 


Leu Met Arg Asn His Glu Ile Ile Gln Gln Pro Met Lys Glu Glu Lys 
225                 230                 235                 240 


Val Ala Ser Leu Met Leu Lys Glu Ala Leu Ala Phe Ile Glu Arg Tyr 
                245                 250                 255     


Lys Arg Glu Pro Phe Leu Leu Phe Phe Ser Phe Leu His Val His Thr 
            260                 265                 270         


Pro Leu Ile Ser Lys Lys Lys Phe Val Gly Arg Ser Lys Tyr Gly Arg 
        275                 280                 285             


Tyr Gly Asp Asn Val Glu Glu Met Asp Trp Met Val Gly Lys Ile Leu 
    290                 295                 300                 


Asp Ala Leu Asp Gln Glu Arg Leu Ala Asn His Thr Leu Val Tyr Phe 
305                 310                 315                 320 


Thr Ser Asp Asn Gly Gly His Leu Glu Pro Leu Asp Gly Ala Val Gln 
                325                 330                 335     


Leu Gly Gly Trp Asn Gly Ile Tyr Lys Gly Gly Lys Gly Met Gly Gly 
            340                 345                 350         


Trp Glu Gly Gly Ile Arg Val Pro Gly Ile Phe Arg Trp Pro Ser Val 
        355                 360                 365             


Leu Glu Ala Gly Arg Val Ile Asn Glu Pro Thr Ser Leu Met Asp Ile 
    370                 375                 380                 


Tyr Pro Thr Leu Ser Tyr Ile Gly Gly Gly Ile Leu Ser Gln Asp Arg 
385                 390                 395                 400 


Val Ile Asp Gly Gln Asn Leu Met Pro Leu Leu Glu Gly Arg Ala Ser 
                405                 410                 415     


His Ser Asp His Glu Phe Leu Phe His Tyr Cys Gly Val Tyr Leu His 
            420                 425                 430         


Thr Val Arg Trp His Gln Lys Asp Cys Ala Thr Val Trp Lys Ala His 
        435                 440                 445             


Tyr Val Thr Pro Lys Phe Tyr Pro Glu Gly Thr Gly Ala Cys Tyr Gly 
    450                 455                 460                 


Ser Gly Ile Cys Ser Cys Ser Gly Asp Val Thr Tyr His Asp Pro Pro 
465                 470                 475                 480 


Leu Leu Phe Asp Ile Ser Arg Asp Pro Ser Glu Ala Leu Pro Leu Asn 
                485                 490                 495     


Pro Asp Asn Glu Pro Leu Phe Asp Ser Val Ile Lys Lys Met Glu Ala 
            500                 505                 510         


Ala Ile Arg Glu His Arg Arg Thr Leu Thr Pro Val Pro Gln Gln Phe 
        515                 520                 525             


Ser Val Phe Asn Thr Ile Trp Lys Pro Trp Leu Gln Pro Cys Cys Gly 
    530                 535                 540                 


Thr Phe Pro Phe Cys Gly Cys Asp Lys Glu Asp Asp Ile Leu Pro Met 
545                 550                 555                 560 


Ala Pro 
        


<210>  4116
<211>  2012
<212>  DNA
<213>  Homosapiens

<400>  4116
cctttgcaga acagcctgtc tgttctgctc ctagacatta gagagataat acggctgata     60

gacaacaaga aggtattcca agctgcacaa tgaggcccag gagacccttg gtcttcatgt    120

ctttggtgtg tgcactcttg aacacatgcc aggcacacag ggtgcatgac gacaagccta    180

atattgtcct aatcatggtt gatgacctgg gtattggaga tctgggctgc tacggcaatg    240

acaccatgag gacgcctcac atcgaccgcc ttgccaggga aggcgtgcga ctgactcagc    300

acatctctgc cgcctccctc tgcagcccaa gccggtccgc gttcttgacg ggaagatacc    360

ccatccgatc aggtatggtt tctagtggta atagacgtgt catccaaaat cttgcagtcc    420

ccgcaggcct ccctcttaat gagacaacac ttgcagcctt gctaaagaag caaggataca    480

gcacggggct tataggcaaa tggcaccaag gcttgaactg cgactcccga agtgaccagt    540

gccaccatcc atataattat gggtttgact actactatgg catgccgttc actctcgttg    600

acagctgctg gccggacccc tctcgtaaca cggaattagc ctttgagagt cagctctggc    660

tctgtgtgca gctagttgcc attgccatcc tcaccctaac ctttgggaag ctgagcggct    720

gggtctctgt tccctggctc ctgatcttct ccatgattct gtttattttc ctcttgggct    780

atgcttggtt ctccagccac acgtcccctt tatactggga ctgcctcctc atgcgggggc    840

acgagatcac ggagcagccc atgaaggctg aacgagctgg atccattatg gtgaaggaag    900

cgatttcctt tttagaaagg cacagtaagg aaactttcct tctctttttc tcctttcttc    960

acgtgcacac acctctcccc accacggacg atttcactgg caccagcaag catggcttgt   1020

atggggataa tgtggaagag atggactcca tggtgggcaa gattcttgat gctatcgatg   1080

attttggcct aaggaacaac acccttgtct actttacatc agatcacgga gggcatttgg   1140

aagctaggcg agggcatgcc caacttggtg gatggaatgg aatatacaaa ggtggaaaag   1200

gcatgggggg ctgggaaggt ggaatccgcg tcccaggaat tgtccgatgg cctggaaagg   1260

taccagctgg acggttgatt aaggaaccta caagtttaat ggatatttta ccaactgtcg   1320

catcagtgtc aggaggaagt ctccctcagg acagggtcat tgacggccga gacctcatgc   1380

ccttgctgca gggcaacgtc aggcactcgg agcatgaatt tcttttccac tactgtggct   1440

cctacctgca cgccgtgcgg tggatcccca aggacgacag tgggtcagtt tggaaggctc   1500

actatgtgac cccggtattc cagccaccag cttctggtgg ctgctatgtc acctcattat   1560

gcagatgttt cggagaacag gttacctacc acaacccccc tctgctcttc gatctctcca   1620

gggacccctc agagtccaca cccctgacac ctgccacaga gcccctccat gattttgtga   1680

ttaaaaaggt ggccaacgcc ctgaaggaac accaggaaac catcgtgcct gtgacctacc   1740

aactctcaga actgaatcag ggcaggacgt ggctgaagcc ttgctgtggg gtgttcccat   1800

tttgtctgtg tgacaaggaa gaggaagtct ctcagcctcg gggtcctaac gagaagagat   1860

aattacaatc aggctaccag aggaagcctt tggtcctaac gagaagagat aattacaatc   1920

aggctaccaa aggaagcact aactttggtg ctttcaagtt ggcaaggagt gcatttaata   1980

gtcaataaat tcatctacca ttccagatta tt                                 2012


<210>  4117
<211>  590
<212>  PRT
<213>  Homosapiens

<400>  4117

Met Arg Pro Arg Arg Pro Leu Val Phe Met Ser Leu Val Cys Ala Leu 
1               5                   10                  15      


Leu Asn Thr Cys Gln Ala His Arg Val His Asp Asp Lys Pro Asn Ile 
            20                  25                  30          


Val Leu Ile Met Val Asp Asp Leu Gly Ile Gly Asp Leu Gly Cys Tyr 
        35                  40                  45              


Gly Asn Asp Thr Met Arg Thr Pro His Ile Asp Arg Leu Ala Arg Glu 
    50                  55                  60                  


Gly Val Arg Leu Thr Gln His Ile Ser Ala Ala Ser Leu Cys Ser Pro 
65                  70                  75                  80  


Ser Arg Ser Ala Phe Leu Thr Gly Arg Tyr Pro Ile Arg Ser Gly Met 
                85                  90                  95      


Val Ser Ser Gly Asn Arg Arg Val Ile Gln Asn Leu Ala Val Pro Ala 
            100                 105                 110         


Gly Leu Pro Leu Asn Glu Thr Thr Leu Ala Ala Leu Leu Lys Lys Gln 
        115                 120                 125             


Gly Tyr Ser Thr Gly Leu Ile Gly Lys Trp His Gln Gly Leu Asn Cys 
    130                 135                 140                 


Asp Ser Arg Ser Asp Gln Cys His His Pro Tyr Asn Tyr Gly Phe Asp 
145                 150                 155                 160 


Tyr Tyr Tyr Gly Met Pro Phe Thr Leu Val Asp Ser Cys Trp Pro Asp 
                165                 170                 175     


Pro Ser Arg Asn Thr Glu Leu Ala Phe Glu Ser Gln Leu Trp Leu Cys 
            180                 185                 190         


Val Gln Leu Val Ala Ile Ala Ile Leu Thr Leu Thr Phe Gly Lys Leu 
        195                 200                 205             


Ser Gly Trp Val Ser Val Pro Trp Leu Leu Ile Phe Ser Met Ile Leu 
    210                 215                 220                 


Phe Ile Phe Leu Leu Gly Tyr Ala Trp Phe Ser Ser His Thr Ser Pro 
225                 230                 235                 240 


Leu Tyr Trp Asp Cys Leu Leu Met Arg Gly His Glu Ile Thr Glu Gln 
                245                 250                 255     


Pro Met Lys Ala Glu Arg Ala Gly Ser Ile Met Val Lys Glu Ala Ile 
            260                 265                 270         


Ser Phe Leu Glu Arg His Ser Lys Glu Thr Phe Leu Leu Phe Phe Ser 
        275                 280                 285             


Phe Leu His Val His Thr Pro Leu Pro Thr Thr Asp Asp Phe Thr Gly 
    290                 295                 300                 


Thr Ser Lys His Gly Leu Tyr Gly Asp Asn Val Glu Glu Met Asp Ser 
305                 310                 315                 320 


Met Val Gly Lys Ile Leu Asp Ala Ile Asp Asp Phe Gly Leu Arg Asn 
                325                 330                 335     


Asn Thr Leu Val Tyr Phe Thr Ser Asp His Gly Gly His Leu Glu Ala 
            340                 345                 350         


Arg Arg Gly His Ala Gln Leu Gly Gly Trp Asn Gly Ile Tyr Lys Gly 
        355                 360                 365             


Gly Lys Gly Met Gly Gly Trp Glu Gly Gly Ile Arg Val Pro Gly Ile 
    370                 375                 380                 


Val Arg Trp Pro Gly Lys Val Pro Ala Gly Arg Leu Ile Lys Glu Pro 
385                 390                 395                 400 


Thr Ser Leu Met Asp Ile Leu Pro Thr Val Ala Ser Val Ser Gly Gly 
                405                 410                 415     


Ser Leu Pro Gln Asp Arg Val Ile Asp Gly Arg Asp Leu Met Pro Leu 
            420                 425                 430         


Leu Gln Gly Asn Val Arg His Ser Glu His Glu Phe Leu Phe His Tyr 
        435                 440                 445             


Cys Gly Ser Tyr Leu His Ala Val Arg Trp Ile Pro Lys Asp Asp Ser 
    450                 455                 460                 


Gly Ser Val Trp Lys Ala His Tyr Val Thr Pro Val Phe Gln Pro Pro 
465                 470                 475                 480 


Ala Ser Gly Gly Cys Tyr Val Thr Ser Leu Cys Arg Cys Phe Gly Glu 
                485                 490                 495     


Gln Val Thr Tyr His Asn Pro Pro Leu Leu Phe Asp Leu Ser Arg Asp 
            500                 505                 510         


Pro Ser Glu Ser Thr Pro Leu Thr Pro Ala Thr Glu Pro Leu His Asp 
        515                 520                 525             


Phe Val Ile Lys Lys Val Ala Asn Ala Leu Lys Glu His Gln Glu Thr 
    530                 535                 540                 


Ile Val Pro Val Thr Tyr Gln Leu Ser Glu Leu Asn Gln Gly Arg Thr 
545                 550                 555                 560 


Trp Leu Lys Pro Cys Cys Gly Val Phe Pro Phe Cys Leu Cys Asp Lys 
                565                 570                 575     


Glu Glu Glu Val Ser Gln Pro Arg Gly Pro Asn Glu Lys Arg 
            580                 585                 590 


<210>  4118
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  4118
atgcccaagc gcgcgcactg gggggccctc tccgtggtgc tgatcctgct ttggggccat     60

ccgcgagtgg cgctggcctg cccgcatcct tgtgcctgct acgtccccag cgaggtccac    120

tgcacgttcc gatccctggc ttccgtgccc gctggcattg ctagacacgt ggaaagaatc    180

aatttggggt ttaatagcat acaggccctg tcagaaacct catttgcagg actgaccaag    240

ttggagctac ttatgattca cggcaatgag atcccaagca tccccgatgg agctttaaga    300

gacctcagct ctcttcaggt tttcaagttc agctacaaca agctgagagt gatcacagga    360

cagaccctcc agggtctctc taacttaatg aggctgcaca ttgaccacaa caagatcgag    420

tttatccacc ctcaagcttt caacggctta acgtctctga ggctactcca tttggaagga    480

aatctcctcc accagctgca ccccagcacc ttctccacgt tcacattttt ggattatttc    540

agactctcca ccataaggca cctctactta gcagagaaca tggttagaac tcttcctgcc    600

agcatgcttc ggaacatgcc gcttctggag aatctttact tgcagggaaa tccgtggacc    660

tgcgattgtg agatgagatg gtttttggaa tgggatgcaa aatccagagg aattctgaag    720

tgtaaaaagg acaaagctta tgaaggcggt cagttgtgtg caatgtgctt cagtccaaag    780

aagttgtaca aacatgagat acacaagctg aaggacatga cttgtctgaa gccttcaata    840

gagtcccctc tgagacagaa caggagcagg agtattgagg aggagcaaga acaggaagag    900

gatggtggca gccagctcat cctggagaaa ttccaactgc cccagtggag catctctttg    960

aatatgaccg acgagcacgg gaacatggtg aacttggtct gtgacatcaa gaaaccaatg   1020

gatgtgtaca agattcactt gaaccaaacg gatcctccag atattgacat aaatgcaaca   1080

gttgccttgg actttgagtg tccaatgacc cgagaaaact atgaaaagct atggaaattg   1140

atagcatact acagtgaagt tcccgtgaag ctacacagag agctcatgct cagcaaagac   1200

cccagagtca gctaccagta caggcaggat gctgatgagg aagctcttta ctacacaggt   1260

gtgagagccc agattcttgc agaaccagaa tgggtcatgc agccatccat agatatccag   1320

ctgaaccgac gtcagagtac ggccaagaag gtgctacttt cctactacac ccagtattct   1380

caaacaatat ccaccaaaga tacaaggcag gctcggggca gaagctgggt aatgattgag   1440

cctagtggag ctgtgcaaag agatcagact gtcctggaag ggggtccatg ccagttgagc   1500

tgcaacgtga aagcttctga gagtccatct atcttctggg tgcttccaga tggctccatc   1560

ctgaaagcgc ccatggatga cccagacagc aagttctcca ttctcagcag tggctggctg   1620

aggatcaagt ccatggagcc atctgactca ggcttgtacc agtgcattgc tcaagtgagg   1680

gatgaaatgg accgcatggt atatagggta cttgtgcagt ctccctccac tcagccagcc   1740

gagaaagaca cagtgacaat tggcaagaac ccaggggagt cggtgacatt gccttgcaat   1800

gctttagcaa tacccgaagc ccaccttagc tggattcttc caaacagaag gataattaat   1860

gatttggcta acacatcaca tgtatacatg ttgccaaatg gaactctttc catcccaaag   1920

gtccaagtca gtgatagtgg ttactacaga tgtgtggctg tcaaccagca aggggcagac   1980

cattttacgg tgggaatcac agtgaccaag aaagggtctg gcttgccatc caaaagaggc   2040

agacgcccag gtgcaaaggc tctttccaga gtcagagaag acatcgtgga ggatgaaggg   2100

ggctcgggca tgggagatga agagaacact tcaaggagac ttctgcatcc aaaggaccaa   2160

gaggtgttcc tcaaaacaaa ggatgatgcc atcaatggag acaagaaagc caagaaaggg   2220

agaagaaagc tgaaactctg gaagcattcg gaaaaagaac cagagaccaa tgttgcagaa   2280

ggtcgcagag tgtttgaatc tagacgaagg ataaacatgg caaacaaaca gattaatccg   2340

gagcgctggg ctgatatttt agccaaagtc cgtgggaaaa atctccctaa gggcacagaa   2400

gtacccccgt tgattaaaac cacaagtcct ccatccttga gcctagaagt cacaccacct   2460

tttcctgctg tttctccccc ctcagcatct cctgtgcaga cagtaaccag tgctgaagaa   2520

tcctcagcag atgtacctct acttggtgaa gaagagcacg ttttgggtac catttcctca   2580

gccagcatgg ggctagaaca caaccacaat ggagttattc ttgttgaacc tgaagtaaca   2640

agcacacctc tggaggaagt tgttgatgac ctttctgaga agactgagga gataacttcc   2700

actgaaggag acctgaaggg gacagcagcc cctacactta tatctgagcc ttatgaacca   2760

tctcctactc tgcacacatt agacacagtc tatgaaaagc ccacccatga agagacggca   2820

acagagggtt ggtctgcagc agatgttgga tcgtcaccag agcccacatc cagtgagtat   2880

gagcctccat tggatgctgt ctccttggct gagtctgagc ccatgcaata ctttgaccca   2940

gatttggaga ctaagtcaca accagatgag gataagatga aagaagacac ctttgcacac   3000

cttactccaa cccccaccat ctgggttaat gactccagta catcacagtt atttgaggat   3060

tctactatag gggaaccagg tgtcccaggc caatcacatc tacaaggact gacagacaac   3120

atccaccttg tgaaaagtag tctaagcact caagacacct tactgattaa aaagggtatg   3180

aaagagatgt ctcagacact acagggagga aatatgctag agggagaccc cacacactcc   3240

agaagttctg agagtgaggg ccaagagagc aaatccatca ctttgcctga ctccacactg   3300

ggtataatga gcagtatgtc tccagttaag aagcctgcgg aaaccacagt tggtaccctc   3360

ctagacaaag acaccacaac agtaacaaca acaccaaggc aaaaagttgc tccgtcatcc   3420

accatgagca ctcacccttc tcgaaggaga cccaacggga gaaggagatt acgccccaac   3480

aaattccgcc accggcacaa gcaaacccca cccacaactt ttgccccatc agagactttt   3540

tctactcaac caactcaagc acctgacatt aagatttcaa gtcaagtgga gagttctctg   3600

gttcctacag cttgggtgga taacacagtt aataccccca aacagttgga aatggagaag   3660

aatgcagaac ccacatccaa gggaacacca cggagaaaac acgggaagag gccaaacaaa   3720

catcgatata ccccttctac agtgagctca agagcgtccg gatccaagcc cagcccttct   3780

ccagaaaata aacatagaaa cattgttact cccagttcag aaactatact tttgcctaga   3840

actgtttctc tgaaaactga gggcccttat gattccttag attacatgac aaccaccaga   3900

aaaatatatt catcttaccc taaagtccaa gagacacttc cagtcacata taaacccaca   3960

tcagatggaa aagaaattaa ggatgatgtt gccacaaatg ttgacaaaca taaaagtgac   4020

attttagtca ctggtgaatc aattactaat gccataccaa cttctcgctc cttggtctcc   4080

actatgggag aatttaagga agaatcctct cctgtaggct ttccaggaac tccaacctgg   4140

aatccctcaa ggacggccca gcctgggagg ctacagacag acatacctgt taccacttct   4200

ggggaaaatc ttacagaccc tccccttctt aaagagcttg aggatgtgga tttcacttcc   4260

gagtttttgt cctctttgac agtctccaca ccatttcacc aggaagaagc tggttcttcc   4320

acaactctct caagcataaa agtggaggtg gcttcaagtc aggcagaaac caccaccctt   4380

gatcaagatc atcttgaaac cactgtggct attctccttt ctgaaactag accacagaat   4440

cacaccccta ctgctgcccg gatgaaggag ccagcatcct cgtccccatc cacaattctc   4500

atgtctttgg gacaaaccac caccactaag ccagcacttc ccagtccaag aatatctcaa   4560

gcatctagag attccaagga aaatgttttc ttgaattatg tggggaatcc agaaacagaa   4620

gcaaccccag tcaacaatga aggaacacag catatgtcag ggccaaatga attatcaaca   4680

ccctcttccg accgggatgc atttaacttg tctacaaagc tggaattgga aaagcaagta   4740

tttggtagta ggagtctacc acgtggccca gatagccaac gccaggatgg aagagttcat   4800

gcttctcatc aactaaccag agtccctgcc aaacccatcc taccaacagc aacagtgagg   4860

ctacctgaaa tgtccacaca aagcgcttcc agatactttg taacttccca gtcacctcgt   4920

cactggacca acaaaccgga aataactaca tatccttctg gggctttgcc agagaacaaa   4980

cagtttacaa ctccaagatt atcaagtaca acaattcctc tcccattgca catgtccaaa   5040

cccagcattc ctagtaagtt tactgaccga agaactgacc aattcaatgg ttactccaaa   5100

gtgtttggaa ataacaacat ccctgaggca agaaacccag ttggaaagcc tcccagtcca   5160

agaattcctc attattccaa tggaagactc cctttcttta ccaacaagac tctttctttt   5220

ccacagttgg gagtcacccg gagaccccag atacccactt ctcctgcccc agtaatgaga   5280

gagagaaaag ttattccagg ttcctacaac aggatacatt cccatagcac cttccatctg   5340

gactttggcc ctccggcacc tccgttgttg cacactccgc agaccacggg atcaccctca   5400

actaacttac agaatatccc tatggtctct tccacccaga gttctatctc ctttataaca   5460

tcttctgtcc agtcctcagg aagcttccac cagagcagct caaagttctt tgcaggagga   5520

cctcctgcat ccaaattctg gtctcttggg gaaaagcccc aaatcctcac caagtcccca   5580

cagactgtgt ccgtcaccgc tgagacagac actgtgttcc cctgtgaggc aacaggaaaa   5640

ccaaagcctt tcgttacttg gacaaaggtt tccacaggag ctcttatgac tccgaatacc   5700

aggatacaac ggtttgaggt tctcaagaac ggtaccttag tgatacggaa ggttcaagta   5760

caagatcgag gccagtatat gtgcaccgcc agcaacctgc acggcctgga caggatggtg   5820

gtcttgcttt cggtcaccgt gcagcaacct caaatcctag cctcccacta ccaggacgtc   5880

actgtctacc tgggagacac cattgcaatg gagtgtctgg ccaaagggac cccagccccc   5940

caaatttcct ggatcttccc tgacaggagg gtgtggcaaa ctgtgtcccc cgtggagagc   6000

cgcatcaccc tgcacgaaaa ccggaccctt tccatcaagg aggcgtcctt ctcagacaga   6060

ggcgtctata agtgcgtggc cagcaatgca gccggggcgg acagcctggc catccgcctg   6120

cacgtggcgg cactgccccc cgttatccac caggagaagc tggagaacat ctcgctgccc   6180

ccggggctca gcattcacat tcactgcact gccaaggctg cgcccctgcc cagcgtgcgc   6240

tgggtgctcg gggacggtac ccagatccgc ccctcgcagt tcctccacgg gaacttgttt   6300

gttttcccca acgggacgct ctacatccgc aacctcgcgc ccaaggacag cgggcgctat   6360

gagtgcgtgg ccgccaacct ggtaggctcc gcgcgcagga cggtgcagct gaacgtgcag   6420

cgtgcagcag ccaacgcgcg catcacgggc acctccccgc ggaggacgga cgtcaggtac   6480

ggaggaaccc tcaagctgga ctgcagcgcc tcgggggacc cctggccgcg catcctctgg   6540

aggctgccgt ccaagaggat gatcgacgcg ctcttcagtt ttgatagcag aatcaaggtg   6600

tttgccaatg ggaccctggt ggtgaaatca gtgacggaca aagatgccgg agattacctg   6660

tgcgtagctc gaaataaggt tggtgatgac tacgtggtgc tcaaagtgga tgtggtgatg   6720

aaaccggcca agattgaaca caaggaggag aacgaccaca aagtcttcta cgggggtgac   6780

ctgaaagtgg actgtgtggc caccgggctt cccaatcccg agatctcctg gagcctccca   6840

gacgggagtc tggtgaactc cttcatgcag tcggatgaca gcggtggacg caccaagcgc   6900

tatgtcgtct tcaacaatgg gacactctac tttaacgaag tggggatgag ggaggaagga   6960

gactacacct gctttgctga aaatcaggtc gggaaggacg agatgagagt cagagtcaag   7020

gtggtgacag cgcccgccac catccggaac aagacttact tggcggttca ggtgccctat   7080

ggagacgtgg tcactgtagc ctgtgaggcc aaaggagaac ccatgcccaa ggtgacttgg   7140

ttgtccccaa ccaacaaggt gatccccacc tcctctgaga agtatcagat ataccaagat   7200

ggcactctcc ttattcagaa agcccagcgt tctgacagcg gcaactacac ctgcctggtc   7260

aggaacagcg cgggagagga taggaagacg gtgtggattc acgtcaacgt ccagccaccc   7320

aagatcaacg gtaaccccaa ccccatcacc accgtgcggg agatagcagc cgggggcagt   7380

cggaaactga ttgactgcaa agctgaaggc atccccaccc cgagggtgtt atgggctttt   7440

cccgagggtg tggttctgcc agctccatac tatggaaacc ggatcactgt ccatggcaac   7500

ggttccctgg acatcaggag tttgaggaag agcgactccg tccagctggt atgcatggca   7560

cgcaacgagg gaggggaggc gaggttgatc gtgcagctca ctgtcctgga gcccatggag   7620

aaacccatct tccacgaccc gatcagcgag aagatcacgg ccatggcggg ccacaccatc   7680

agcctcaact gctctgccgc ggggaccccg acacccagcc tggtgtgggt ccttcccaat   7740

ggcaccgatc tgcagagtgg acagcagctg cagcgcttct accacaaggc tgacggcatg   7800

ctacacatta gcggtctctc ctcggtggac gctggggcct accgctgcgt ggcccgcaat   7860

gccgctggcc acacggagag gctggtctcc ctgaaggtgg gactgaagcc agaagcaaac   7920

aagcagtatc ataacctggt cagcatcatc aatggtgaga ccctgaagct cccctgcacc   7980

cctcccgggg ctgggcaggg acgtttctcc tggacgctcc ccaatggcat gcatctggag   8040

ggcccccaaa ccctgggacg cgtttctctt ctggacaatg gcaccctcac ggttcgtgag   8100

gcctcggtgt ttgacagggg tacctatgta tgcaggatgg agacggagta cggcccttcg   8160

gtcaccagca tccccgtgat tgtgatcgcc ta                                 8192


<210>  4119
<211>  2828
<212>  PRT
<213>  Homosapiens

<400>  4119

Met Pro Lys Arg Ala His Trp Gly Ala Leu Ser Val Val Leu Ile Leu 
1               5                   10                  15      


Leu Trp Gly His Pro Arg Val Ala Leu Ala Cys Pro His Pro Cys Ala 
            20                  25                  30          


Cys Tyr Val Pro Ser Glu Val His Cys Thr Phe Arg Ser Leu Ala Ser 
        35                  40                  45              


Val Pro Ala Gly Ile Ala Arg His Val Glu Arg Ile Asn Leu Gly Phe 
    50                  55                  60                  


Asn Ser Ile Gln Ala Leu Ser Glu Thr Ser Phe Ala Gly Leu Thr Lys 
65                  70                  75                  80  


Leu Glu Leu Leu Met Ile His Gly Asn Glu Ile Pro Ser Ile Pro Asp 
                85                  90                  95      


Gly Ala Leu Arg Asp Leu Ser Ser Leu Gln Val Phe Lys Phe Ser Tyr 
            100                 105                 110         


Asn Lys Leu Arg Val Ile Thr Gly Gln Thr Leu Gln Gly Leu Ser Asn 
        115                 120                 125             


Leu Met Arg Leu His Ile Asp His Asn Lys Ile Glu Phe Ile His Pro 
    130                 135                 140                 


Gln Ala Phe Asn Gly Leu Thr Ser Leu Arg Leu Leu His Leu Glu Gly 
145                 150                 155                 160 


Asn Leu Leu His Gln Leu His Pro Ser Thr Phe Ser Thr Phe Thr Phe 
                165                 170                 175     


Leu Asp Tyr Phe Arg Leu Ser Thr Ile Arg His Leu Tyr Leu Ala Glu 
            180                 185                 190         


Asn Met Val Arg Thr Leu Pro Ala Ser Met Leu Arg Asn Met Pro Leu 
        195                 200                 205             


Leu Glu Asn Leu Tyr Leu Gln Gly Asn Pro Trp Thr Cys Asp Cys Glu 
    210                 215                 220                 


Met Arg Trp Phe Leu Glu Trp Asp Ala Lys Ser Arg Gly Ile Leu Lys 
225                 230                 235                 240 


Cys Lys Lys Asp Lys Ala Tyr Glu Gly Gly Gln Leu Cys Ala Met Cys 
                245                 250                 255     


Phe Ser Pro Lys Lys Leu Tyr Lys His Glu Ile His Lys Leu Lys Asp 
            260                 265                 270         


Met Thr Cys Leu Lys Pro Ser Ile Glu Ser Pro Leu Arg Gln Asn Arg 
        275                 280                 285             


Ser Arg Ser Ile Glu Glu Glu Gln Glu Gln Glu Glu Asp Gly Gly Ser 
    290                 295                 300                 


Gln Leu Ile Leu Glu Lys Phe Gln Leu Pro Gln Trp Ser Ile Ser Leu 
305                 310                 315                 320 


Asn Met Thr Asp Glu His Gly Asn Met Val Asn Leu Val Cys Asp Ile 
                325                 330                 335     


Lys Lys Pro Met Asp Val Tyr Lys Ile His Leu Asn Gln Thr Asp Pro 
            340                 345                 350         


Pro Asp Ile Asp Ile Asn Ala Thr Val Ala Leu Asp Phe Glu Cys Pro 
        355                 360                 365             


Met Thr Arg Glu Asn Tyr Glu Lys Leu Trp Lys Leu Ile Ala Tyr Tyr 
    370                 375                 380                 


Ser Glu Val Pro Val Lys Leu His Arg Glu Leu Met Leu Ser Lys Asp 
385                 390                 395                 400 


Pro Arg Val Ser Tyr Gln Tyr Arg Gln Asp Ala Asp Glu Glu Ala Leu 
                405                 410                 415     


Tyr Tyr Thr Gly Val Arg Ala Gln Ile Leu Ala Glu Pro Glu Trp Val 
            420                 425                 430         


Met Gln Pro Ser Ile Asp Ile Gln Leu Asn Arg Arg Gln Ser Thr Ala 
        435                 440                 445             


Lys Lys Val Leu Leu Ser Tyr Tyr Thr Gln Tyr Ser Gln Thr Ile Ser 
    450                 455                 460                 


Thr Lys Asp Thr Arg Gln Ala Arg Gly Arg Ser Trp Val Met Ile Glu 
465                 470                 475                 480 


Pro Ser Gly Ala Val Gln Arg Asp Gln Thr Val Leu Glu Gly Gly Pro 
                485                 490                 495     


Cys Gln Leu Ser Cys Asn Val Lys Ala Ser Glu Ser Pro Ser Ile Phe 
            500                 505                 510         


Trp Val Leu Pro Asp Gly Ser Ile Leu Lys Ala Pro Met Asp Asp Pro 
        515                 520                 525             


Asp Ser Lys Phe Ser Ile Leu Ser Ser Gly Trp Leu Arg Ile Lys Ser 
    530                 535                 540                 


Met Glu Pro Ser Asp Ser Gly Leu Tyr Gln Cys Ile Ala Gln Val Arg 
545                 550                 555                 560 


Asp Glu Met Asp Arg Met Val Tyr Arg Val Leu Val Gln Ser Pro Ser 
                565                 570                 575     


Thr Gln Pro Ala Glu Lys Asp Thr Val Thr Ile Gly Lys Asn Pro Gly 
            580                 585                 590         


Glu Ser Val Thr Leu Pro Cys Asn Ala Leu Ala Ile Pro Glu Ala His 
        595                 600                 605             


Leu Ser Trp Ile Leu Pro Asn Arg Arg Ile Ile Asn Asp Leu Ala Asn 
    610                 615                 620                 


Thr Ser His Val Tyr Met Leu Pro Asn Gly Thr Leu Ser Ile Pro Lys 
625                 630                 635                 640 


Val Gln Val Ser Asp Ser Gly Tyr Tyr Arg Cys Val Ala Val Asn Gln 
                645                 650                 655     


Gln Gly Ala Asp His Phe Thr Val Gly Ile Thr Val Thr Lys Lys Gly 
            660                 665                 670         


Ser Gly Leu Pro Ser Lys Arg Gly Arg Arg Pro Gly Ala Lys Ala Leu 
        675                 680                 685             


Ser Arg Val Arg Glu Asp Ile Val Glu Asp Glu Gly Gly Ser Gly Met 
    690                 695                 700                 


Gly Asp Glu Glu Asn Thr Ser Arg Arg Leu Leu His Pro Lys Asp Gln 
705                 710                 715                 720 


Glu Val Phe Leu Lys Thr Lys Asp Asp Ala Ile Asn Gly Asp Lys Lys 
                725                 730                 735     


Ala Lys Lys Gly Arg Arg Lys Leu Lys Leu Trp Lys His Ser Glu Lys 
            740                 745                 750         


Glu Pro Glu Thr Asn Val Ala Glu Gly Arg Arg Val Phe Glu Ser Arg 
        755                 760                 765             


Arg Arg Ile Asn Met Ala Asn Lys Gln Ile Asn Pro Glu Arg Trp Ala 
    770                 775                 780                 


Asp Ile Leu Ala Lys Val Arg Gly Lys Asn Leu Pro Lys Gly Thr Glu 
785                 790                 795                 800 


Val Pro Pro Leu Ile Lys Thr Thr Ser Pro Pro Ser Leu Ser Leu Glu 
                805                 810                 815     


Val Thr Pro Pro Phe Pro Ala Val Ser Pro Pro Ser Ala Ser Pro Val 
            820                 825                 830         


Gln Thr Val Thr Ser Ala Glu Glu Ser Ser Ala Asp Val Pro Leu Leu 
        835                 840                 845             


Gly Glu Glu Glu His Val Leu Gly Thr Ile Ser Ser Ala Ser Met Gly 
    850                 855                 860                 


Leu Glu His Asn His Asn Gly Val Ile Leu Val Glu Pro Glu Val Thr 
865                 870                 875                 880 


Ser Thr Pro Leu Glu Glu Val Val Asp Asp Leu Ser Glu Lys Thr Glu 
                885                 890                 895     


Glu Ile Thr Ser Thr Glu Gly Asp Leu Lys Gly Thr Ala Ala Pro Thr 
            900                 905                 910         


Leu Ile Ser Glu Pro Tyr Glu Pro Ser Pro Thr Leu His Thr Leu Asp 
        915                 920                 925             


Thr Val Tyr Glu Lys Pro Thr His Glu Glu Thr Ala Thr Glu Gly Trp 
    930                 935                 940                 


Ser Ala Ala Asp Val Gly Ser Ser Pro Glu Pro Thr Ser Ser Glu Tyr 
945                 950                 955                 960 


Glu Pro Pro Leu Asp Ala Val Ser Leu Ala Glu Ser Glu Pro Met Gln 
                965                 970                 975     


Tyr Phe Asp Pro Asp Leu Glu Thr Lys Ser Gln Pro Asp Glu Asp Lys 
            980                 985                 990         


Met Lys Glu Asp Thr Phe Ala His  Leu Thr Pro Thr Pro  Thr Ile Trp 
        995                 1000                 1005             


Val Asn  Asp Ser Ser Thr Ser  Gln Leu Phe Glu Asp  Ser Thr Ile 
    1010                 1015                 1020             


Gly Glu  Pro Gly Val Pro Gly  Gln Ser His Leu Gln  Gly Leu Thr 
    1025                 1030                 1035             


Asp Asn  Ile His Leu Val Lys  Ser Ser Leu Ser Thr  Gln Asp Thr 
    1040                 1045                 1050             


Leu Leu  Ile Lys Lys Gly Met  Lys Glu Met Ser Gln  Thr Leu Gln 
    1055                 1060                 1065             


Gly Gly  Asn Met Leu Glu Gly  Asp Pro Thr His Ser  Arg Ser Ser 
    1070                 1075                 1080             


Glu Ser  Glu Gly Gln Glu Ser  Lys Ser Ile Thr Leu  Pro Asp Ser 
    1085                 1090                 1095             


Thr Leu  Gly Ile Met Ser Ser  Met Ser Pro Val Lys  Lys Pro Ala 
    1100                 1105                 1110             


Glu Thr  Thr Val Gly Thr Leu  Leu Asp Lys Asp Thr  Thr Thr Val 
    1115                 1120                 1125             


Thr Thr  Thr Pro Arg Gln Lys  Val Ala Pro Ser Ser  Thr Met Ser 
    1130                 1135                 1140             


Thr His  Pro Ser Arg Arg Arg  Pro Asn Gly Arg Arg  Arg Leu Arg 
    1145                 1150                 1155             


Pro Asn  Lys Phe Arg His Arg  His Lys Gln Thr Pro  Pro Thr Thr 
    1160                 1165                 1170             


Phe Ala  Pro Ser Glu Thr Phe  Ser Thr Gln Pro Thr  Gln Ala Pro 
    1175                 1180                 1185             


Asp Ile  Lys Ile Ser Ser Gln  Val Glu Ser Ser Leu  Val Pro Thr 
    1190                 1195                 1200             


Ala Trp  Val Asp Asn Thr Val  Asn Thr Pro Lys Gln  Leu Glu Met 
    1205                 1210                 1215             


Glu Lys  Asn Ala Glu Pro Thr  Ser Lys Gly Thr Pro  Arg Arg Lys 
    1220                 1225                 1230             


His Gly  Lys Arg Pro Asn Lys  His Arg Tyr Thr Pro  Ser Thr Val 
    1235                 1240                 1245             


Ser Ser  Arg Ala Ser Gly Ser  Lys Pro Ser Pro Ser  Pro Glu Asn 
    1250                 1255                 1260             


Lys His  Arg Asn Ile Val Thr  Pro Ser Ser Glu Thr  Ile Leu Leu 
    1265                 1270                 1275             


Pro Arg  Thr Val Ser Leu Lys  Thr Glu Gly Pro Tyr  Asp Ser Leu 
    1280                 1285                 1290             


Asp Tyr  Met Thr Thr Thr Arg  Lys Ile Tyr Ser Ser  Tyr Pro Lys 
    1295                 1300                 1305             


Val Gln  Glu Thr Leu Pro Val  Thr Tyr Lys Pro Thr  Ser Asp Gly 
    1310                 1315                 1320             


Lys Glu  Ile Lys Asp Asp Val  Ala Thr Asn Val Asp  Lys His Lys 
    1325                 1330                 1335             


Ser Asp  Ile Leu Val Thr Gly  Glu Ser Ile Thr Asn  Ala Ile Pro 
    1340                 1345                 1350             


Thr Ser  Arg Ser Leu Val Ser  Thr Met Gly Glu Phe  Lys Glu Glu 
    1355                 1360                 1365             


Ser Ser  Pro Val Gly Phe Pro  Gly Thr Pro Thr Trp  Asn Pro Ser 
    1370                 1375                 1380             


Arg Thr  Ala Gln Pro Gly Arg  Leu Gln Thr Asp Ile  Pro Val Thr 
    1385                 1390                 1395             


Thr Ser  Gly Glu Asn Leu Thr  Asp Pro Pro Leu Leu  Lys Glu Leu 
    1400                 1405                 1410             


Glu Asp  Val Asp Phe Thr Ser  Glu Phe Leu Ser Ser  Leu Thr Val 
    1415                 1420                 1425             


Ser Thr  Pro Phe His Gln Glu  Glu Ala Gly Ser Ser  Thr Thr Leu 
    1430                 1435                 1440             


Ser Ser  Ile Lys Val Glu Val  Ala Ser Ser Gln Ala  Glu Thr Thr 
    1445                 1450                 1455             


Thr Leu  Asp Gln Asp His Leu  Glu Thr Thr Val Ala  Ile Leu Leu 
    1460                 1465                 1470             


Ser Glu  Thr Arg Pro Gln Asn  His Thr Pro Thr Ala  Ala Arg Met 
    1475                 1480                 1485             


Lys Glu  Pro Ala Ser Ser Ser  Pro Ser Thr Ile Leu  Met Ser Leu 
    1490                 1495                 1500             


Gly Gln  Thr Thr Thr Thr Lys  Pro Ala Leu Pro Ser  Pro Arg Ile 
    1505                 1510                 1515             


Ser Gln  Ala Ser Arg Asp Ser  Lys Glu Asn Val Phe  Leu Asn Tyr 
    1520                 1525                 1530             


Val Gly  Asn Pro Glu Thr Glu  Ala Thr Pro Val Asn  Asn Glu Gly 
    1535                 1540                 1545             


Thr Gln  His Met Ser Gly Pro  Asn Glu Leu Ser Thr  Pro Ser Ser 
    1550                 1555                 1560             


Asp Arg  Asp Ala Phe Asn Leu  Ser Thr Lys Leu Glu  Leu Glu Lys 
    1565                 1570                 1575             


Gln Val  Phe Gly Ser Arg Ser  Leu Pro Arg Gly Pro  Asp Ser Gln 
    1580                 1585                 1590             


Arg Gln  Asp Gly Arg Val His  Ala Ser His Gln Leu  Thr Arg Val 
    1595                 1600                 1605             


Pro Ala  Lys Pro Ile Leu Pro  Thr Ala Thr Val Arg  Leu Pro Glu 
    1610                 1615                 1620             


Met Ser  Thr Gln Ser Ala Ser  Arg Tyr Phe Val Thr  Ser Gln Ser 
    1625                 1630                 1635             


Pro Arg  His Trp Thr Asn Lys  Pro Glu Ile Thr Thr  Tyr Pro Ser 
    1640                 1645                 1650             


Gly Ala  Leu Pro Glu Asn Lys  Gln Phe Thr Thr Pro  Arg Leu Ser 
    1655                 1660                 1665             


Ser Thr  Thr Ile Pro Leu Pro  Leu His Met Ser Lys  Pro Ser Ile 
    1670                 1675                 1680             


Pro Ser  Lys Phe Thr Asp Arg  Arg Thr Asp Gln Phe  Asn Gly Tyr 
    1685                 1690                 1695             


Ser Lys  Val Phe Gly Asn Asn  Asn Ile Pro Glu Ala  Arg Asn Pro 
    1700                 1705                 1710             


Val Gly  Lys Pro Pro Ser Pro  Arg Ile Pro His Tyr  Ser Asn Gly 
    1715                 1720                 1725             


Arg Leu  Pro Phe Phe Thr Asn  Lys Thr Leu Ser Phe  Pro Gln Leu 
    1730                 1735                 1740             


Gly Val  Thr Arg Arg Pro Gln  Ile Pro Thr Ser Pro  Ala Pro Val 
    1745                 1750                 1755             


Met Arg  Glu Arg Lys Val Ile  Pro Gly Ser Tyr Asn  Arg Ile His 
    1760                 1765                 1770             


Ser His  Ser Thr Phe His Leu  Asp Phe Gly Pro Pro  Ala Pro Pro 
    1775                 1780                 1785             


Leu Leu  His Thr Pro Gln Thr  Thr Gly Ser Pro Ser  Thr Asn Leu 
    1790                 1795                 1800             


Gln Asn  Ile Pro Met Val Ser  Ser Thr Gln Ser Ser  Ile Ser Phe 
    1805                 1810                 1815             


Ile Thr  Ser Ser Val Gln Ser  Ser Gly Ser Phe His  Gln Ser Ser 
    1820                 1825                 1830             


Ser Lys  Phe Phe Ala Gly Gly  Pro Pro Ala Ser Lys  Phe Trp Ser 
    1835                 1840                 1845             


Leu Gly  Glu Lys Pro Gln Ile  Leu Thr Lys Ser Pro  Gln Thr Val 
    1850                 1855                 1860             


Ser Val  Thr Ala Glu Thr Asp  Thr Val Phe Pro Cys  Glu Ala Thr 
    1865                 1870                 1875             


Gly Lys  Pro Lys Pro Phe Val  Thr Trp Thr Lys Val  Ser Thr Gly 
    1880                 1885                 1890             


Ala Leu  Met Thr Pro Asn Thr  Arg Ile Gln Arg Phe  Glu Val Leu 
    1895                 1900                 1905             


Lys Asn  Gly Thr Leu Val Ile  Arg Lys Val Gln Val  Gln Asp Arg 
    1910                 1915                 1920             


Gly Gln  Tyr Met Cys Thr Ala  Ser Asn Leu His Gly  Leu Asp Arg 
    1925                 1930                 1935             


Met Val  Val Leu Leu Ser Val  Thr Val Gln Gln Pro  Gln Ile Leu 
    1940                 1945                 1950             


Ala Ser  His Tyr Gln Asp Val  Thr Val Tyr Leu Gly  Asp Thr Ile 
    1955                 1960                 1965             


Ala Met  Glu Cys Leu Ala Lys  Gly Thr Pro Ala Pro  Gln Ile Ser 
    1970                 1975                 1980             


Trp Ile  Phe Pro Asp Arg Arg  Val Trp Gln Thr Val  Ser Pro Val 
    1985                 1990                 1995             


Glu Ser  Arg Ile Thr Leu His  Glu Asn Arg Thr Leu  Ser Ile Lys 
    2000                 2005                 2010             


Glu Ala  Ser Phe Ser Asp Arg  Gly Val Tyr Lys Cys  Val Ala Ser 
    2015                 2020                 2025             


Asn Ala  Ala Gly Ala Asp Ser  Leu Ala Ile Arg Leu  His Val Ala 
    2030                 2035                 2040             


Ala Leu  Pro Pro Val Ile His  Gln Glu Lys Leu Glu  Asn Ile Ser 
    2045                 2050                 2055             


Leu Pro  Pro Gly Leu Ser Ile  His Ile His Cys Thr  Ala Lys Ala 
    2060                 2065                 2070             


Ala Pro  Leu Pro Ser Val Arg  Trp Val Leu Gly Asp  Gly Thr Gln 
    2075                 2080                 2085             


Ile Arg  Pro Ser Gln Phe Leu  His Gly Asn Leu Phe  Val Phe Pro 
    2090                 2095                 2100             


Asn Gly  Thr Leu Tyr Ile Arg  Asn Leu Ala Pro Lys  Asp Ser Gly 
    2105                 2110                 2115             


Arg Tyr  Glu Cys Val Ala Ala  Asn Leu Val Gly Ser  Ala Arg Arg 
    2120                 2125                 2130             


Thr Val  Gln Leu Asn Val Gln  Arg Ala Ala Ala Asn  Ala Arg Ile 
    2135                 2140                 2145             


Thr Gly  Thr Ser Pro Arg Arg  Thr Asp Val Arg Tyr  Gly Gly Thr 
    2150                 2155                 2160             


Leu Lys  Leu Asp Cys Ser Ala  Ser Gly Asp Pro Trp  Pro Arg Ile 
    2165                 2170                 2175             


Leu Trp  Arg Leu Pro Ser Lys  Arg Met Ile Asp Ala  Leu Phe Ser 
    2180                 2185                 2190             


Phe Asp  Ser Arg Ile Lys Val  Phe Ala Asn Gly Thr  Leu Val Val 
    2195                 2200                 2205             


Lys Ser  Val Thr Asp Lys Asp  Ala Gly Asp Tyr Leu  Cys Val Ala 
    2210                 2215                 2220             


Arg Asn  Lys Val Gly Asp Asp  Tyr Val Val Leu Lys  Val Asp Val 
    2225                 2230                 2235             


Val Met  Lys Pro Ala Lys Ile  Glu His Lys Glu Glu  Asn Asp His 
    2240                 2245                 2250             


Lys Val  Phe Tyr Gly Gly Asp  Leu Lys Val Asp Cys  Val Ala Thr 
    2255                 2260                 2265             


Gly Leu  Pro Asn Pro Glu Ile  Ser Trp Ser Leu Pro  Asp Gly Ser 
    2270                 2275                 2280             


Leu Val  Asn Ser Phe Met Gln  Ser Asp Asp Ser Gly  Gly Arg Thr 
    2285                 2290                 2295             


Lys Arg  Tyr Val Val Phe Asn  Asn Gly Thr Leu Tyr  Phe Asn Glu 
    2300                 2305                 2310             


Val Gly  Met Arg Glu Glu Gly  Asp Tyr Thr Cys Phe  Ala Glu Asn 
    2315                 2320                 2325             


Gln Val  Gly Lys Asp Glu Met  Arg Val Arg Val Lys  Val Val Thr 
    2330                 2335                 2340             


Ala Pro  Ala Thr Ile Arg Asn  Lys Thr Tyr Leu Ala  Val Gln Val 
    2345                 2350                 2355             


Pro Tyr  Gly Asp Val Val Thr  Val Ala Cys Glu Ala  Lys Gly Glu 
    2360                 2365                 2370             


Pro Met  Pro Lys Val Thr Trp  Leu Ser Pro Thr Asn  Lys Val Ile 
    2375                 2380                 2385             


Pro Thr  Ser Ser Glu Lys Tyr  Gln Ile Tyr Gln Asp  Gly Thr Leu 
    2390                 2395                 2400             


Leu Ile  Gln Lys Ala Gln Arg  Ser Asp Ser Gly Asn  Tyr Thr Cys 
    2405                 2410                 2415             


Leu Val  Arg Asn Ser Ala Gly  Glu Asp Arg Lys Thr  Val Trp Ile 
    2420                 2425                 2430             


His Val  Asn Val Gln Pro Pro  Lys Ile Asn Gly Asn  Pro Asn Pro 
    2435                 2440                 2445             


Ile Thr  Thr Val Arg Glu Ile  Ala Ala Gly Gly Ser  Arg Lys Leu 
    2450                 2455                 2460             


Ile Asp  Cys Lys Ala Glu Gly  Ile Pro Thr Pro Arg  Val Leu Trp 
    2465                 2470                 2475             


Ala Phe  Pro Glu Gly Val Val  Leu Pro Ala Pro Tyr  Tyr Gly Asn 
    2480                 2485                 2490             


Arg Ile  Thr Val His Gly Asn  Gly Ser Leu Asp Ile  Arg Ser Leu 
    2495                 2500                 2505             


Arg Lys  Ser Asp Ser Val Gln  Leu Val Cys Met Ala  Arg Asn Glu 
    2510                 2515                 2520             


Gly Gly  Glu Ala Arg Leu Ile  Val Gln Leu Thr Val  Leu Glu Pro 
    2525                 2530                 2535             


Met Glu  Lys Pro Ile Phe His  Asp Pro Ile Ser Glu  Lys Ile Thr 
    2540                 2545                 2550             


Ala Met  Ala Gly His Thr Ile  Ser Leu Asn Cys Ser  Ala Ala Gly 
    2555                 2560                 2565             


Thr Pro  Thr Pro Ser Leu Val  Trp Val Leu Pro Asn  Gly Thr Asp 
    2570                 2575                 2580             


Leu Gln  Ser Gly Gln Gln Leu  Gln Arg Phe Tyr His  Lys Ala Asp 
    2585                 2590                 2595             


Gly Met  Leu His Ile Ser Gly  Leu Ser Ser Val Asp  Ala Gly Ala 
    2600                 2605                 2610             


Tyr Arg  Cys Val Ala Arg Asn  Ala Ala Gly His Thr  Glu Arg Leu 
    2615                 2620                 2625             


Val Ser  Leu Lys Val Gly Leu  Lys Pro Glu Ala Asn  Lys Gln Tyr 
    2630                 2635                 2640             


His Asn  Leu Val Ser Ile Ile  Asn Gly Glu Thr Leu  Lys Leu Pro 
    2645                 2650                 2655             


Cys Thr  Pro Pro Gly Ala Gly  Gln Gly Arg Phe Ser  Trp Thr Leu 
    2660                 2665                 2670             


Pro Asn  Gly Met His Leu Glu  Gly Pro Gln Thr Leu  Gly Arg Val 
    2675                 2680                 2685             


Ser Leu  Leu Asp Asn Gly Thr  Leu Thr Val Arg Glu  Ala Ser Val 
    2690                 2695                 2700             


Phe Asp  Arg Gly Thr Tyr Val  Cys Arg Met Glu Thr  Glu Tyr Gly 
    2705                 2710                 2715             


Pro Ser  Val Thr Ser Ile Pro  Val Ile Val Ile Ala  Tyr Pro Pro 
    2720                 2725                 2730             


Arg Ile  Thr Ser Glu Pro Thr  Pro Val Ile Tyr Thr  Arg Pro Gly 
    2735                 2740                 2745             


Asn Thr  Val Lys Leu Asn Cys  Met Ala Met Gly Ile  Pro Lys Ala 
    2750                 2755                 2760             


Asp Ile  Thr Trp Glu Leu Pro  Asp Lys Ser His Leu  Lys Ala Gly 
    2765                 2770                 2775             


Val Gln  Ala Arg Leu Tyr Gly  Asn Arg Phe Leu His  Pro Gln Gly 
    2780                 2785                 2790             


Ser Leu  Thr Ile Gln His Ala  Thr Gln Arg Asp Ala  Gly Phe Tyr 
    2795                 2800                 2805             


Lys Cys  Met Ala Lys Asn Ile  Leu Gly Ser Asp Ser  Lys Thr Thr 
    2810                 2815                 2820             


Tyr Ile  His Val Phe 
    2825             


<210>  4120
<211>  3844
<212>  DNA
<213>  Homosapiens

<400>  4120
aaaggcaggc attctctttc cttttccttc tctcctgagc gctcctgcag ttcctggggc     60

gtagtagggg atccacaagc gtttgtgacc agtgaagttc tttacaaggg tgagatctgc    120

acgggaggac ccgagcgagg gtctcggctt gccaggaagc cggggttccc cgggaagcgt    180

ggagttcacc cgcgcactcg aagtgccttt gcaaaattat atctgggtgt tggcacccag    240

ccactattct gccaatgaag tacatcctgg tcacgggtgg ggtcatctca ggcattggta    300

aagggatcat tgccagcagc attggaacga ttctaaaatc atgtggactc cgagttactg    360

ccataaaaat cgacccctat attaacatcg atgctggcac tttttcacct tatgaacacg    420

gtgaagtctt cgtcttaaat gatggtggag aagttgattt agaccttgga aattatgaaa    480

gatttttgga tattaatctt tataaagaca acaatatcac cacggggaag atatatcagc    540

atgtgatcaa taaagagagg cgtggtgatt acctggggaa aacagtgcaa gttgtccctc    600

acattactga tgctgtccag gagtgggtta tgaatcaagc caaggtgccg gtggatggta    660

ataaggaaga gccccaaata tgcgttattg agctgggagg caccattgga gacatcgaag    720

gaatgccgtt tgtggaggcg tttagacaat tccagtttaa ggcgaaaaga gagaatttct    780

gtaatatcca cgttagcctt gtcccacagc tcagtgctac cggagaacaa aaaaccaaac    840

ccacccaaaa cagcgtccgc gcactgaggg gtttaggcct gtctccagat ctgattgtct    900

gccgaagttc aacgcccatt gagatggccg tgaaggagaa gatttctatg ttttgtcacg    960

tgaaccctga acaggtcata tgtatccatg atgtttcttc cacataccga gttcctgtgc   1020

ttttagagga acaaagcatt gtgaaatatt ttaaggagag attgcacctg cccatcggtg   1080

attctgcaag taatttgctt tttaagtgga gaaatatggc tgacaggtat gaaaggttac   1140

agaaaatatg ctccatagcc ctggttggca aatacaccaa gctcagagac tgctacgcct   1200

ctgtgttcaa agccctggaa cactcagccc tggccatcaa ccacaagttg aatctgatgt   1260

acatagactc cattgatctg gagaagatca ctgaaaccga ggaccctgtg aaatttcatg   1320

aagcttggca gaagctatgc aaagctgatg gtattcttgt gcctggaggc tttggaatca   1380

gaggaacatt gggaaaactc caggcgattt cttgggcaag gacaaagaag attccttttc   1440

tgggagtttg tcttgggatg caactagcag tgatagagtt tgcaagaaac tgccttaact   1500

tgaaagatgc tgattccaca gagtttaggc caaatgcccc agttcctctg gtgattgata   1560

tgcccgagca caaccctggc aatttgggag gaacaatgag actgggaata agaagaactg   1620

ttttcaaaac tgaaaattca atattaagga aactttatgg tgatgttcct tttatagaag   1680

aaagacacag acatcggttc gaggtaaacc ctaacctgat caaacaattt gagcagaatg   1740

acttaagttt tgtaggtcag gatgttgatg gagacaggat ggaaatcatt gaactggcaa   1800

atcatcctta ttttgttggt gtccagttcc atcctgagtt ttcttctagg ccgatgaagc   1860

cttcccctcc gtatctgggg ctgttacttg cagcaactgg gaacctgaat gcctacttgc   1920

aacagggttg caaactgtct tccagtgata gatacagtga tgccagtgat gacagctttt   1980

cagagccaag gatagctgag ttggaaataa gctgaaatga atacatgact gggaataatg   2040

gggactgcct gtgaggcctc tgaaataatt gaaggcaaga tgaaggaact atctgaagaa   2100

atcactacac tcttagagaa tccctctgtt ctccagcaaa catgggatgt aaagcctcac   2160

agggaatctg ataatacata cttctgtcaa ccagaaccag aggggtagtt ttcttttccc   2220

tccagaggca gcctttggta cttaaaatat ctgtagctga ttaaattttt cccaacaacc   2280

tcactgggga gaaagtgtgt tcatgttttg tccagcggat caggatgtta ggatgacgag   2340

caagagtcca ggtcactgtg cctttgctgt gttgtatgga aaggatggca gggaacatgc   2400

tgtaagtaat tttgagtaag aaaatgagtc actgtgttac ctggaactca gccacagatt   2460

tgtgtgtggt ccaagatcat tgcagtttct caccctgttt atttcctggt aaaagtaaaa   2520

ttgaataggt ccaagacttg ggggtggcaa gtaaggcttt gcctcaggca caaaatttaa   2580

gggggctcca aaaaactcag gaatcaagat cagcaataca gtctgagtat cccttatgtg   2640

aaatgcttgg ggctagaagt gttttgaatt tcagattttg gaatatttgc atatacatgc   2700

gatatcttgg ggatgagact caagactaaa catgaaattc atttatgctt catatacacc   2760

ttatatacat agcctaaagg taatttgata caatatttta aataattttg tgcatgaaac   2820

aaagtttcga ctgcattttg actgtgattt ctggcatgag atcagttatg gaattttcca   2880

cttctagcgt catgttggca ttcagaaatt ttgaaatttt ggagcatttt ggattttcag   2940

attagggatg ctcaacctgt atatatattt tttaatcgac gtgaaattca cgtaacatag   3000

aattaaccat tttgaagtga acaatttggt tgcattcact gatgttgagc aaccaccacc   3060

tttaactatt tccaaaacat tttcatcact ccaaaataaa tgcctgtaca cactagcagt   3120

cactccctat cttcccctcc acctgtccgc tggcaaccac tgatctcctt tttatttctg   3180

tggctttttc tattctggat atttcatata agtggaatta cacaatatat gtggtctttt   3240

gtgtctggct tcttctgaga cagtaggaag ggggcttggc tttggctcac ccccactaga   3300

gcattttttc atgcattccc actgatcaca aaacccatac tactacctca ttgacaccat   3360

acctgctaac ctcgaggctt tagtcataca aagaaaatgg cctttctgta ttgttcttct   3420

gtgctctcat aatgcttaac catgtctttt acttaaacaa ttccaggaac tggccttagg   3480

agatccaaat agggaaccaa gattgcagag tgtcccatct tgggagggaa tgctgaataa   3540

ttaattgatt tacagccttg ttgccgctgg ccagaccacc aggtggccca ttactcgaga   3600

tgatcatcac aaccagatga tgctaaccta tatcctctac ccttcgcgtg ctttgtctgg   3660

gaagtctttt ggccccatgt cagtttctat tgcattgaga gcccaagagc ccctggtcag   3720

tcaggcttcc atttagcatg gcgtttgcaa ggtttaccca tgttgtagca tgtgtcagaa   3780

tttcattcct ttctatggct gaataaaatt ccattgtatg aatataccac aaaaaaaaaa   3840

aaaa                                                                3844


<210>  4121
<211>  586
<212>  PRT
<213>  Homosapiens

<400>  4121

Met Lys Tyr Ile Leu Val Thr Gly Gly Val Ile Ser Gly Ile Gly Lys 
1               5                   10                  15      


Gly Ile Ile Ala Ser Ser Ile Gly Thr Ile Leu Lys Ser Cys Gly Leu 
            20                  25                  30          


Arg Val Thr Ala Ile Lys Ile Asp Pro Tyr Ile Asn Ile Asp Ala Gly 
        35                  40                  45              


Thr Phe Ser Pro Tyr Glu His Gly Glu Val Phe Val Leu Asn Asp Gly 
    50                  55                  60                  


Gly Glu Val Asp Leu Asp Leu Gly Asn Tyr Glu Arg Phe Leu Asp Ile 
65                  70                  75                  80  


Asn Leu Tyr Lys Asp Asn Asn Ile Thr Thr Gly Lys Ile Tyr Gln His 
                85                  90                  95      


Val Ile Asn Lys Glu Arg Arg Gly Asp Tyr Leu Gly Lys Thr Val Gln 
            100                 105                 110         


Val Val Pro His Ile Thr Asp Ala Val Gln Glu Trp Val Met Asn Gln 
        115                 120                 125             


Ala Lys Val Pro Val Asp Gly Asn Lys Glu Glu Pro Gln Ile Cys Val 
    130                 135                 140                 


Ile Glu Leu Gly Gly Thr Ile Gly Asp Ile Glu Gly Met Pro Phe Val 
145                 150                 155                 160 


Glu Ala Phe Arg Gln Phe Gln Phe Lys Ala Lys Arg Glu Asn Phe Cys 
                165                 170                 175     


Asn Ile His Val Ser Leu Val Pro Gln Leu Ser Ala Thr Gly Glu Gln 
            180                 185                 190         


Lys Thr Lys Pro Thr Gln Asn Ser Val Arg Ala Leu Arg Gly Leu Gly 
        195                 200                 205             


Leu Ser Pro Asp Leu Ile Val Cys Arg Ser Ser Thr Pro Ile Glu Met 
    210                 215                 220                 


Ala Val Lys Glu Lys Ile Ser Met Phe Cys His Val Asn Pro Glu Gln 
225                 230                 235                 240 


Val Ile Cys Ile His Asp Val Ser Ser Thr Tyr Arg Val Pro Val Leu 
                245                 250                 255     


Leu Glu Glu Gln Ser Ile Val Lys Tyr Phe Lys Glu Arg Leu His Leu 
            260                 265                 270         


Pro Ile Gly Asp Ser Ala Ser Asn Leu Leu Phe Lys Trp Arg Asn Met 
        275                 280                 285             


Ala Asp Arg Tyr Glu Arg Leu Gln Lys Ile Cys Ser Ile Ala Leu Val 
    290                 295                 300                 


Gly Lys Tyr Thr Lys Leu Arg Asp Cys Tyr Ala Ser Val Phe Lys Ala 
305                 310                 315                 320 


Leu Glu His Ser Ala Leu Ala Ile Asn His Lys Leu Asn Leu Met Tyr 
                325                 330                 335     


Ile Asp Ser Ile Asp Leu Glu Lys Ile Thr Glu Thr Glu Asp Pro Val 
            340                 345                 350         


Lys Phe His Glu Ala Trp Gln Lys Leu Cys Lys Ala Asp Gly Ile Leu 
        355                 360                 365             


Val Pro Gly Gly Phe Gly Ile Arg Gly Thr Leu Gly Lys Leu Gln Ala 
    370                 375                 380                 


Ile Ser Trp Ala Arg Thr Lys Lys Ile Pro Phe Leu Gly Val Cys Leu 
385                 390                 395                 400 


Gly Met Gln Leu Ala Val Ile Glu Phe Ala Arg Asn Cys Leu Asn Leu 
                405                 410                 415     


Lys Asp Ala Asp Ser Thr Glu Phe Arg Pro Asn Ala Pro Val Pro Leu 
            420                 425                 430         


Val Ile Asp Met Pro Glu His Asn Pro Gly Asn Leu Gly Gly Thr Met 
        435                 440                 445             


Arg Leu Gly Ile Arg Arg Thr Val Phe Lys Thr Glu Asn Ser Ile Leu 
    450                 455                 460                 


Arg Lys Leu Tyr Gly Asp Val Pro Phe Ile Glu Glu Arg His Arg His 
465                 470                 475                 480 


Arg Phe Glu Val Asn Pro Asn Leu Ile Lys Gln Phe Glu Gln Asn Asp 
                485                 490                 495     


Leu Ser Phe Val Gly Gln Asp Val Asp Gly Asp Arg Met Glu Ile Ile 
            500                 505                 510         


Glu Leu Ala Asn His Pro Tyr Phe Val Gly Val Gln Phe His Pro Glu 
        515                 520                 525             


Phe Ser Ser Arg Pro Met Lys Pro Ser Pro Pro Tyr Leu Gly Leu Leu 
    530                 535                 540                 


Leu Ala Ala Thr Gly Asn Leu Asn Ala Tyr Leu Gln Gln Gly Cys Lys 
545                 550                 555                 560 


Leu Ser Ser Ser Asp Arg Tyr Ser Asp Ala Ser Asp Asp Ser Phe Ser 
                565                 570                 575     


Glu Pro Arg Ile Ala Glu Leu Glu Ile Ser 
            580                 585     


<210>  4122
<211>  3947
<212>  DNA
<213>  Homosapiens

<400>  4122
gggtgacggg agctgcctgt gctggaggaa tcacttttta ggcgcttgtt ttggaccatt     60

gcacaaaccc gggtgcaaac cccaagctca ccagcgtgag tgagctgggc cagcagcagg    120

gaggagaggg gaaggtgggc gaggagggcg ccgcgcaccc cgaggcccgt gtgggcggtg    180

ggaagatccc gggggcggct ttggacagcc ccggcagcga ccccttcccc agcccgacag    240

gtgagcgcca ggccagccgc ggggtggagc ccgccgtgcc caccggccac cctccccggt    300

gctaccacca ccgcgcagat tatatctggg tgttggcacc cagccactat tctgccaatg    360

aagtacatcc tggtcacggg tggggtcatc tcaggcattg gtaaagggat cattgccagc    420

agcattggaa cgattctaaa atcatgtgga ctccgagtta ctgccataaa aatcgacccc    480

tatattaaca tcgatgctgg cactttttca ccttatgaac acggtgaagt cttcgtctta    540

aatgatggtg gagaagttga tttagacctt ggaaattatg aaagattttt ggatattaat    600

ctttataaag acaacaatat caccacgggg aagatatatc agcatgtgat caataaagag    660

aggcgtggtg attacctggg gaaaacagtg caagttgtcc ctcacattac tgatgctgtc    720

caggagtggg ttatgaatca agccaaggtg ccggtggatg gtaataagga agagccccaa    780

atatgcgtta ttgagctggg aggcaccatt ggagacatcg aaggaatgcc gtttgtggag    840

gcgtttagac aattccagtt taaggcgaaa agagagaatt tctgtaatat ccacgttagc    900

cttgtcccac agctcagtgc taccggagaa caaaaaacca aacccaccca aaacagcgtc    960

cgcgcactga ggggtttagg cctgtctcca gatctgattg tctgccgaag ttcaacgccc   1020

attgagatgg ccgtgaagga gaagatttct atgttttgtc acgtgaaccc tgaacaggtc   1080

atatgtatcc atgatgtttc ttccacatac cgagttcctg tgcttttaga ggaacaaagc   1140

attgtgaaat attttaagga gagattgcac ctgcccatcg gtgattctgc aagtaatttg   1200

ctttttaagt ggagaaatat ggctgacagg tatgaaaggt tacagaaaat atgctccata   1260

gccctggttg gcaaatacac caagctcaga gactgctacg cctctgtgtt caaagccctg   1320

gaacactcag ccctggccat caaccacaag ttgaatctga tgtacataga ctccattgat   1380

ctggagaaga tcactgaaac cgaggaccct gtgaaatttc atgaagcttg gcagaagcta   1440

tgcaaagctg atggtattct tgtgcctgga ggctttggaa tcagaggaac attgggaaaa   1500

ctccaggcga tttcttgggc aaggacaaag aagattcctt ttctgggagt ttgtcttggg   1560

atgcaactag cagtgataga gtttgcaaga aactgcctta acttgaaaga tgctgattcc   1620

acagagttta ggccaaatgc cccagttcct ctggtgattg atatgcccga gcacaaccct   1680

ggcaatttgg gaggaacaat gagactggga ataagaagaa ctgttttcaa aactgaaaat   1740

tcaatattaa ggaaacttta tggtgatgtt ccttttatag aagaaagaca cagacatcgg   1800

ttcgaggtaa accctaacct gatcaaacaa tttgagcaga atgacttaag ttttgtaggt   1860

caggatgttg atggagacag gatggaaatc attgaactgg caaatcatcc ttattttgtt   1920

ggtgtccagt tccatcctga gttttcttct aggccgatga agccttcccc tccgtatctg   1980

gggctgttac ttgcagcaac tgggaacctg aatgcctact tgcaacaggg ttgcaaactg   2040

tcttccagtg atagatacag tgatgccagt gatgacagct tttcagagcc aaggatagct   2100

gagttggaaa taagctgaaa tgaatacatg actgggaata atggggactg cctgtgaggc   2160

ctctgaaata attgaaggca agatgaagga actatctgaa gaaatcacta cactcttaga   2220

gaatccctct gttctccagc aaacatggga tgtaaagcct cacagggaat ctgataatac   2280

atacttctgt caaccagaac cagaggggta gttttctttt ccctccagag gcagcctttg   2340

gtacttaaaa tatctgtagc tgattaaatt tttcccaaca acctcactgg ggagaaagtg   2400

tgttcatgtt ttgtccagcg gatcaggatg ttaggatgac gagcaagagt ccaggtcact   2460

gtgcctttgc tgtgttgtat ggaaaggatg gcagggaaca tgctgtaagt aattttgagt   2520

aagaaaatga gtcactgtgt tacctggaac tcagccacag atttgtgtgt ggtccaagat   2580

cattgcagtt tctcaccctg tttatttcct ggtaaaagta aaattgaata ggtccaagac   2640

ttgggggtgg caagtaaggc tttgcctcag gcacaaaatt taagggggct ccaaaaaact   2700

caggaatcaa gatcagcaat acagtctgag tatcccttat gtgaaatgct tggggctaga   2760

agtgttttga atttcagatt ttggaatatt tgcatataca tgcgatatct tggggatgag   2820

actcaagact aaacatgaaa ttcatttatg cttcatatac accttatata catagcctaa   2880

aggtaatttg atacaatatt ttaaataatt ttgtgcatga aacaaagttt cgactgcatt   2940

ttgactgtga tttctggcat gagatcagtt atggaatttt ccacttctag cgtcatgttg   3000

gcattcagaa attttgaaat tttggagcat tttggatttt cagattaggg atgctcaacc   3060

tgtatatata ttttttaatc gacgtgaaat tcacgtaaca tagaattaac cattttgaag   3120

tgaacaattt ggttgcattc actgatgttg agcaaccacc acctttaact atttccaaaa   3180

cattttcatc actccaaaat aaatgcctgt acacactagc agtcactccc tatcttcccc   3240

tccacctgtc cgctggcaac cactgatctc ctttttattt ctgtggcttt ttctattctg   3300

gatatttcat ataagtggaa ttacacaata tatgtggtct tttgtgtctg gcttcttctg   3360

agacagtagg aagggggctt ggctttggct cacccccact agagcatttt ttcatgcatt   3420

cccactgatc acaaaaccca tactactacc tcattgacac catacctgct aacctcgagg   3480

ctttagtcat acaaagaaaa tggcctttct gtattgttct tctgtgctct cataatgctt   3540

aaccatgtct tttacttaaa caattccagg aactggcctt aggagatcca aatagggaac   3600

caagattgca gagtgtccca tcttgggagg gaatgctgaa taattaattg atttacagcc   3660

ttgttgccgc tggccagacc accaggtggc ccattactcg agatgatcat cacaaccaga   3720

tgatgctaac ctatatcctc tacccttcgc gtgctttgtc tgggaagtct tttggcccca   3780

tgtcagtttc tattgcattg agagcccaag agcccctggt cagtcaggct tccatttagc   3840

atggcgtttg caaggtttac ccatgttgta gcatgtgtca gaatttcatt cctttctatg   3900

gctgaataaa attccattgt atgaatatac cacaaaaaaa aaaaaaa                 3947


<210>  4123
<211>  586
<212>  PRT
<213>  Homosapiens

<400>  4123

Met Lys Tyr Ile Leu Val Thr Gly Gly Val Ile Ser Gly Ile Gly Lys 
1               5                   10                  15      


Gly Ile Ile Ala Ser Ser Ile Gly Thr Ile Leu Lys Ser Cys Gly Leu 
            20                  25                  30          


Arg Val Thr Ala Ile Lys Ile Asp Pro Tyr Ile Asn Ile Asp Ala Gly 
        35                  40                  45              


Thr Phe Ser Pro Tyr Glu His Gly Glu Val Phe Val Leu Asn Asp Gly 
    50                  55                  60                  


Gly Glu Val Asp Leu Asp Leu Gly Asn Tyr Glu Arg Phe Leu Asp Ile 
65                  70                  75                  80  


Asn Leu Tyr Lys Asp Asn Asn Ile Thr Thr Gly Lys Ile Tyr Gln His 
                85                  90                  95      


Val Ile Asn Lys Glu Arg Arg Gly Asp Tyr Leu Gly Lys Thr Val Gln 
            100                 105                 110         


Val Val Pro His Ile Thr Asp Ala Val Gln Glu Trp Val Met Asn Gln 
        115                 120                 125             


Ala Lys Val Pro Val Asp Gly Asn Lys Glu Glu Pro Gln Ile Cys Val 
    130                 135                 140                 


Ile Glu Leu Gly Gly Thr Ile Gly Asp Ile Glu Gly Met Pro Phe Val 
145                 150                 155                 160 


Glu Ala Phe Arg Gln Phe Gln Phe Lys Ala Lys Arg Glu Asn Phe Cys 
                165                 170                 175     


Asn Ile His Val Ser Leu Val Pro Gln Leu Ser Ala Thr Gly Glu Gln 
            180                 185                 190         


Lys Thr Lys Pro Thr Gln Asn Ser Val Arg Ala Leu Arg Gly Leu Gly 
        195                 200                 205             


Leu Ser Pro Asp Leu Ile Val Cys Arg Ser Ser Thr Pro Ile Glu Met 
    210                 215                 220                 


Ala Val Lys Glu Lys Ile Ser Met Phe Cys His Val Asn Pro Glu Gln 
225                 230                 235                 240 


Val Ile Cys Ile His Asp Val Ser Ser Thr Tyr Arg Val Pro Val Leu 
                245                 250                 255     


Leu Glu Glu Gln Ser Ile Val Lys Tyr Phe Lys Glu Arg Leu His Leu 
            260                 265                 270         


Pro Ile Gly Asp Ser Ala Ser Asn Leu Leu Phe Lys Trp Arg Asn Met 
        275                 280                 285             


Ala Asp Arg Tyr Glu Arg Leu Gln Lys Ile Cys Ser Ile Ala Leu Val 
    290                 295                 300                 


Gly Lys Tyr Thr Lys Leu Arg Asp Cys Tyr Ala Ser Val Phe Lys Ala 
305                 310                 315                 320 


Leu Glu His Ser Ala Leu Ala Ile Asn His Lys Leu Asn Leu Met Tyr 
                325                 330                 335     


Ile Asp Ser Ile Asp Leu Glu Lys Ile Thr Glu Thr Glu Asp Pro Val 
            340                 345                 350         


Lys Phe His Glu Ala Trp Gln Lys Leu Cys Lys Ala Asp Gly Ile Leu 
        355                 360                 365             


Val Pro Gly Gly Phe Gly Ile Arg Gly Thr Leu Gly Lys Leu Gln Ala 
    370                 375                 380                 


Ile Ser Trp Ala Arg Thr Lys Lys Ile Pro Phe Leu Gly Val Cys Leu 
385                 390                 395                 400 


Gly Met Gln Leu Ala Val Ile Glu Phe Ala Arg Asn Cys Leu Asn Leu 
                405                 410                 415     


Lys Asp Ala Asp Ser Thr Glu Phe Arg Pro Asn Ala Pro Val Pro Leu 
            420                 425                 430         


Val Ile Asp Met Pro Glu His Asn Pro Gly Asn Leu Gly Gly Thr Met 
        435                 440                 445             


Arg Leu Gly Ile Arg Arg Thr Val Phe Lys Thr Glu Asn Ser Ile Leu 
    450                 455                 460                 


Arg Lys Leu Tyr Gly Asp Val Pro Phe Ile Glu Glu Arg His Arg His 
465                 470                 475                 480 


Arg Phe Glu Val Asn Pro Asn Leu Ile Lys Gln Phe Glu Gln Asn Asp 
                485                 490                 495     


Leu Ser Phe Val Gly Gln Asp Val Asp Gly Asp Arg Met Glu Ile Ile 
            500                 505                 510         


Glu Leu Ala Asn His Pro Tyr Phe Val Gly Val Gln Phe His Pro Glu 
        515                 520                 525             


Phe Ser Ser Arg Pro Met Lys Pro Ser Pro Pro Tyr Leu Gly Leu Leu 
    530                 535                 540                 


Leu Ala Ala Thr Gly Asn Leu Asn Ala Tyr Leu Gln Gln Gly Cys Lys 
545                 550                 555                 560 


Leu Ser Ser Ser Asp Arg Tyr Ser Asp Ala Ser Asp Asp Ser Phe Ser 
                565                 570                 575     


Glu Pro Arg Ile Ala Glu Leu Glu Ile Ser 
            580                 585     


<210>  4124
<211>  2030
<212>  DNA
<213>  Homosapiens

<400>  4124
tctccctggg agtcgcgcag agtggagtca aaggcaacca gtgctcgctg cggtctctgg     60

ggatcgggac cgcggcggcg gcccgcgagc gggatgttcc ggggcttgag cagttggttg    120

ggcttgcagc agccggtggc aggcggtggg cagcccaatg gagatgctcc acccgagcag    180

ccgtccgaga cggtggctga gtctgcggag gaggagctgc agcaagcggg agaccaggag    240

ctcctccacc aggccaaaga cttcggcaac tatttattta actttgcatc tgctgccaca    300

aaaaagataa ctgaatcagt tgctgaaaca gcacaaacaa taaagaaatc cgtagaagaa    360

ggaaaaatag atggcatcat tgacaagaca attataggag attttcagaa ggaacagaaa    420

aaatttgttg aagagcaaca tacaaagaag tcagaagcag ctgtgccccc atgggttgac    480

actaacgatg aagaaacaat tcaacaacaa attttggcct tatcagctga caagaggaat    540

ttccttcgtg accctccggc tggcgtgcaa tttaatttcg actttgatca gatgtacccc    600

gtggccctgg tcatgctcca ggaggatgag ctgctaagca agatgagatt tgccctcgtt    660

cctaaacttg tgaaggaaga agtgttctgg aggaactact tttaccgcgt ctccctgatt    720

aagcagtcag cccagctcac ggccctggct gcccaacagc aggccgcagg gaaggaggag    780

aagagcaatg gcagagagca agatttgccg ctggcagagg cagtacggcc caaaacgcca    840

cccgttgtaa tcaaatctca gcttaaaact caagaggatg aggaagaaat ttctactagc    900

ccaggtgttt ctgagtttgt cagtgatgcc ttcgatgcct gtaacctaaa tcaggaagat    960

ctaaggaaag aaatggagca actagtgctt gacaaaaagc aagaggagac agccgtactg   1020

gaagaggatt ctgcagattg ggaaaaagaa ctgcagcagg aacttcaaga atatgaagtg   1080

gtgacagaat ctgaaaaacg agatgaaaac tgggataagg aaatagagaa aatgcttcaa   1140

gaggaaaatt agctgttcct gaaatagaag aataatcctt aacagtctgc aaactgacat   1200

taaattctag atgttgacaa ttactgaatc agaaggcatg aaagagtata attttatgaa   1260

attcaaaatt attctttttt caagttgaaa cttgcctctt ctactttaaa aaagtatata   1320

gaacagttac ttctaataat cagaaagaga tgttttatag aacatttctt taatataaag   1380

ttagagatgt cttcataggc agtatggcta tctttgccac agaaacataa gtaaaatttt   1440

agagttctgt tttccatgag gtcaaaaata taatttattc ctcagtcatg gttttctaaa   1500

tatctgtact ccacattcca ttttaattga tatgagggtg ttaaagtacc tacttaatgg   1560

gttgattatt atcaaaatga ccaaattata ccaaagaact taagaggaag cactttcaga   1620

actattcact tgccaggtat tttctaaaat tccacctgaa agccaaaaga taaaataaat   1680

aacttgattt taatgatata agcatcacac aattttacat taagaaatac tgtgcaggcc   1740

atgcgtggtg gctcaggcct gtaatcccag cactttggga ggccgaggtg ggcagatcac   1800

cggaggtcag gagttcgaga ccagccttgc caacatagtg aaaccctgtc tttactaaaa   1860

atacaaaaat tagccgggca tggtggcagg cacctgtaat cccaggtact agggaggctt   1920

ttgaacccag gaggcagagg ttgcagcgag ctgagatcgc gccactgcac tccagcctgg   1980

gtgatagagt gagattcagt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa              2030


<210>  4125
<211>  352
<212>  PRT
<213>  Homosapiens

<400>  4125

Met Phe Arg Gly Leu Ser Ser Trp Leu Gly Leu Gln Gln Pro Val Ala 
1               5                   10                  15      


Gly Gly Gly Gln Pro Asn Gly Asp Ala Pro Pro Glu Gln Pro Ser Glu 
            20                  25                  30          


Thr Val Ala Glu Ser Ala Glu Glu Glu Leu Gln Gln Ala Gly Asp Gln 
        35                  40                  45              


Glu Leu Leu His Gln Ala Lys Asp Phe Gly Asn Tyr Leu Phe Asn Phe 
    50                  55                  60                  


Ala Ser Ala Ala Thr Lys Lys Ile Thr Glu Ser Val Ala Glu Thr Ala 
65                  70                  75                  80  


Gln Thr Ile Lys Lys Ser Val Glu Glu Gly Lys Ile Asp Gly Ile Ile 
                85                  90                  95      


Asp Lys Thr Ile Ile Gly Asp Phe Gln Lys Glu Gln Lys Lys Phe Val 
            100                 105                 110         


Glu Glu Gln His Thr Lys Lys Ser Glu Ala Ala Val Pro Pro Trp Val 
        115                 120                 125             


Asp Thr Asn Asp Glu Glu Thr Ile Gln Gln Gln Ile Leu Ala Leu Ser 
    130                 135                 140                 


Ala Asp Lys Arg Asn Phe Leu Arg Asp Pro Pro Ala Gly Val Gln Phe 
145                 150                 155                 160 


Asn Phe Asp Phe Asp Gln Met Tyr Pro Val Ala Leu Val Met Leu Gln 
                165                 170                 175     


Glu Asp Glu Leu Leu Ser Lys Met Arg Phe Ala Leu Val Pro Lys Leu 
            180                 185                 190         


Val Lys Glu Glu Val Phe Trp Arg Asn Tyr Phe Tyr Arg Val Ser Leu 
        195                 200                 205             


Ile Lys Gln Ser Ala Gln Leu Thr Ala Leu Ala Ala Gln Gln Gln Ala 
    210                 215                 220                 


Ala Gly Lys Glu Glu Lys Ser Asn Gly Arg Glu Gln Asp Leu Pro Leu 
225                 230                 235                 240 


Ala Glu Ala Val Arg Pro Lys Thr Pro Pro Val Val Ile Lys Ser Gln 
                245                 250                 255     


Leu Lys Thr Gln Glu Asp Glu Glu Glu Ile Ser Thr Ser Pro Gly Val 
            260                 265                 270         


Ser Glu Phe Val Ser Asp Ala Phe Asp Ala Cys Asn Leu Asn Gln Glu 
        275                 280                 285             


Asp Leu Arg Lys Glu Met Glu Gln Leu Val Leu Asp Lys Lys Gln Glu 
    290                 295                 300                 


Glu Thr Ala Val Leu Glu Glu Asp Ser Ala Asp Trp Glu Lys Glu Leu 
305                 310                 315                 320 


Gln Gln Glu Leu Gln Glu Tyr Glu Val Val Thr Glu Ser Glu Lys Arg 
                325                 330                 335     


Asp Glu Asn Trp Asp Lys Glu Ile Glu Lys Met Leu Gln Glu Glu Asn 
            340                 345                 350         


<210>  4126
<211>  2045
<212>  DNA
<213>  Homosapiens

<400>  4126
gagattctgt gccccttgtc gggccgcttg tttggctgct gccgtcacct catggcgacg     60

cgggtagagg aggcagcgcg gggaagaggc ggcggcgccg aagaggcgac tgaggccgga    120

cggggcggac ggcgacgcag cccgcggcag aagtttgaaa ttggcacaat ggaagaagct    180

ggaatttgtg ggctaggggt gaaagcagat atgttgtgta actctcaatc aaatgatatt    240

cttcaacatc aaggctcaaa ttgtggtggc acaagtaaca agcattcatt ggaagaggat    300

gaaggcagtg actttataac agagaacagg aatttggtga gcccagcata ctgcacgcaa    360

gaatcaagag aggaaatccc tgggggagaa gctcgaacag atccccctga tggtcagcaa    420

gattcagagt gcaacaggaa caaagaaaaa actttaggaa aagaagtttt attactgatg    480

caagccctaa acaccctttc aaccccagag gagaagctgg cagctctctg taagaaatat    540

gctgatcttc tggaggagag caggagtgtt cagaagcaaa tgaagatcct gcagaagaag    600

caagcccaga ttgtgaaaga gaaagttcac ttgcagagtg aacatagcaa ggctatcttg    660

gcaagaagca agctagaatc tctttgcaga gaacttcagc gtcacaataa gacgttaaag    720

gaggaaaata tgcagcaggc acgagaggaa gaagaacgac gtaaagaagc aactgcacat    780

ttccagatta ccttagatga aattcaagcc cagctggagc agcatgacat ccacaacgcc    840

aaactccgac aggaaaacat tgagctgggg gagaagctaa agaagctcat cgaacagtac    900

gcactgaggg aagagcacat tgataaggtg ttcaaacgta aggaactgca acagcagctc    960

gtggatgcca aactgcagca aacgacacaa ctgataaaag aagctgatga aaaacatcag   1020

agagagagag agtttttatt aaaagaagcg acagaatcga ggcacaaata cgaacaaatg   1080

aaacagcagg aagtacaact aaaacagcag ctttctcttt atatggataa gtttgaagaa   1140

ttccagacta ccatggcaaa aagcaatgaa ctgtttacaa ccttcagaca ggaaatggaa   1200

aagatgacaa agaaaattaa aaaactggaa aaagaaacaa taatttggcg taccaaatgg   1260

gaaaacaata ataaagcact tctgcaaatg gctgaagaga aaacagtccg tgataaagag   1320

tacaaggccc ttcaaataaa actggaacgg ttagagaagc tgtgcagggc tcttcaaaca   1380

gaaaggaatg agctcaatga gaaggtggaa gtcctgaaag agcaggtatc catcaaagcg   1440

gccatcaaag cggcgaacag ggatttagca acacctgtga tgcagccctg tactgccctg   1500

gattctcaca aggagctgaa cacttcctcg aaaagagccc tgggagcgca cctggaggct   1560

gagcccaaga gtcagagaag cgctgtgcaa aagcccccgt ccacaggctc tgctccggcc   1620

atcgagtcgg ttgactaaga tgaggtgtga tcactgtatt gagagatata ttttgtgtat   1680

aactttctct gttagtagtt aactattggt tttgtggtga aaattttctt actttttcta   1740

ccatatctgt attttcttag aactactgga cttatgtggt acaggaggct gcttagcagt   1800

tttgaatagt ttaatctata aattttcctc agctgtgttg cacatcagcc tcgttctccc   1860

tccactggaa tgcatgtgtt cactgccttg tcctttctct ccctgctcct tgcacattat   1920

catcctaatg aaaatttcac tgacagggcc gaccattaca agggaacttt gttctgacga   1980

tggttccttg atgtgaaaac aatattaatt taaacgtctt agcccccccc cccataatat   2040

tattc                                                               2045


<210>  4127
<211>  528
<212>  PRT
<213>  Homosapiens

<400>  4127

Met Ala Thr Arg Val Glu Glu Ala Ala Arg Gly Arg Gly Gly Gly Ala 
1               5                   10                  15      


Glu Glu Ala Thr Glu Ala Gly Arg Gly Gly Arg Arg Arg Ser Pro Arg 
            20                  25                  30          


Gln Lys Phe Glu Ile Gly Thr Met Glu Glu Ala Gly Ile Cys Gly Leu 
        35                  40                  45              


Gly Val Lys Ala Asp Met Leu Cys Asn Ser Gln Ser Asn Asp Ile Leu 
    50                  55                  60                  


Gln His Gln Gly Ser Asn Cys Gly Gly Thr Ser Asn Lys His Ser Leu 
65                  70                  75                  80  


Glu Glu Asp Glu Gly Ser Asp Phe Ile Thr Glu Asn Arg Asn Leu Val 
                85                  90                  95      


Ser Pro Ala Tyr Cys Thr Gln Glu Ser Arg Glu Glu Ile Pro Gly Gly 
            100                 105                 110         


Glu Ala Arg Thr Asp Pro Pro Asp Gly Gln Gln Asp Ser Glu Cys Asn 
        115                 120                 125             


Arg Asn Lys Glu Lys Thr Leu Gly Lys Glu Val Leu Leu Leu Met Gln 
    130                 135                 140                 


Ala Leu Asn Thr Leu Ser Thr Pro Glu Glu Lys Leu Ala Ala Leu Cys 
145                 150                 155                 160 


Lys Lys Tyr Ala Asp Leu Leu Glu Glu Ser Arg Ser Val Gln Lys Gln 
                165                 170                 175     


Met Lys Ile Leu Gln Lys Lys Gln Ala Gln Ile Val Lys Glu Lys Val 
            180                 185                 190         


His Leu Gln Ser Glu His Ser Lys Ala Ile Leu Ala Arg Ser Lys Leu 
        195                 200                 205             


Glu Ser Leu Cys Arg Glu Leu Gln Arg His Asn Lys Thr Leu Lys Glu 
    210                 215                 220                 


Glu Asn Met Gln Gln Ala Arg Glu Glu Glu Glu Arg Arg Lys Glu Ala 
225                 230                 235                 240 


Thr Ala His Phe Gln Ile Thr Leu Asp Glu Ile Gln Ala Gln Leu Glu 
                245                 250                 255     


Gln His Asp Ile His Asn Ala Lys Leu Arg Gln Glu Asn Ile Glu Leu 
            260                 265                 270         


Gly Glu Lys Leu Lys Lys Leu Ile Glu Gln Tyr Ala Leu Arg Glu Glu 
        275                 280                 285             


His Ile Asp Lys Val Phe Lys Arg Lys Glu Leu Gln Gln Gln Leu Val 
    290                 295                 300                 


Asp Ala Lys Leu Gln Gln Thr Thr Gln Leu Ile Lys Glu Ala Asp Glu 
305                 310                 315                 320 


Lys His Gln Arg Glu Arg Glu Phe Leu Leu Lys Glu Ala Thr Glu Ser 
                325                 330                 335     


Arg His Lys Tyr Glu Gln Met Lys Gln Gln Glu Val Gln Leu Lys Gln 
            340                 345                 350         


Gln Leu Ser Leu Tyr Met Asp Lys Phe Glu Glu Phe Gln Thr Thr Met 
        355                 360                 365             


Ala Lys Ser Asn Glu Leu Phe Thr Thr Phe Arg Gln Glu Met Glu Lys 
    370                 375                 380                 


Met Thr Lys Lys Ile Lys Lys Leu Glu Lys Glu Thr Ile Ile Trp Arg 
385                 390                 395                 400 


Thr Lys Trp Glu Asn Asn Asn Lys Ala Leu Leu Gln Met Ala Glu Glu 
                405                 410                 415     


Lys Thr Val Arg Asp Lys Glu Tyr Lys Ala Leu Gln Ile Lys Leu Glu 
            420                 425                 430         


Arg Leu Glu Lys Leu Cys Arg Ala Leu Gln Thr Glu Arg Asn Glu Leu 
        435                 440                 445             


Asn Glu Lys Val Glu Val Leu Lys Glu Gln Val Ser Ile Lys Ala Ala 
    450                 455                 460                 


Ile Lys Ala Ala Asn Arg Asp Leu Ala Thr Pro Val Met Gln Pro Cys 
465                 470                 475                 480 


Thr Ala Leu Asp Ser His Lys Glu Leu Asn Thr Ser Ser Lys Arg Ala 
                485                 490                 495     


Leu Gly Ala His Leu Glu Ala Glu Pro Lys Ser Gln Arg Ser Ala Val 
            500                 505                 510         


Gln Lys Pro Pro Ser Thr Gly Ser Ala Pro Ala Ile Glu Ser Val Asp 
        515                 520                 525             


<210>  4128
<211>  1946
<212>  DNA
<213>  Homosapiens

<400>  4128
gcctcgtcag ctgcctgggc gggctgggag gcgcgggttg aaaagtctcg ttccaagttt     60

ggagagagag agaagagcgc ctcagacctc ggtacccgcg agcggggagg aggcaggaaa    120

gaaggacgcg gcgtctgggg agcacccagg cagcaagacg gggcccgggc tttcgacagt    180

ggggagtgtg acgcgcttgg gaaaggcagg agcgccagcg gtcgggctgc tcttggctaa    240

cgagaggagt ccgaggcggc ggcgaggggc gaacgacccg acgcaagatg gcgagtaaag    300

agatgtttga agatactgtg gaggagcgtg tcatcaatga agaatataaa atctggaaga    360

agaatacacc gtttctatat gacctggtta tgacccatgc tcttcagtgg cccagtctta    420

ccgttcagtg gcttcctgaa gtgactaaac ctgaaggaaa agattatgcc cttcattggc    480

tagtgctggg gactcatacg tctgatgagc agaatcatct ggtggttgct cgagtacata    540

ttcccaatga tgatgcacag tttgatgctt cccattgtga cagtgacaag ggtgaatttg    600

gtggctttgg ttctgtaaca ggaaaaattg aatgtgaaat taaaatcaat cacgaaggag    660

aagtaaaccg tgctcgttac atgccgcaga atcctcacat cattgctaca aaaacaccat    720

cttctgatgt gttggttttt gactatacaa aacaccctgc taaaccagac ccaagtggag    780

aatgtaatcc tgatctcaga ttaagaggtc accagaagga aggctatggt ctctcctgga    840

attcaaattt gagtggacat ctcctaagtg catctgatga ccatactgtt tgtctgtggg    900

atataaacgc aggaccaaaa gaaggcaaaa ttgtggatgc taaagccatc tttactggcc    960

actcagctgt tgtagaggat gtggcctggc acctgctgca cgagtcattg tttggatctg   1020

ttgctgatga tcagaaactt atgatatggg acaccaggtc caataccacc tccaagccga   1080

gtcacttggt ggatgcgcac actgccgaag tcaactgcct ctcattcaat ccctacagcg   1140

aatttattct agccaccggc tctgcggata agaccgtagc tttatgggat ctgcgtaact   1200

taaaattaaa actccatacc ttcgaatctc ataaagatga aattttccag gtccactggt   1260

ctccacataa tgaaactatt ctggcttcaa gtggtactga ccgccgcctg aatgtgtggg   1320

atttaagtaa aattggggaa gaacaatcag cagaagatgc agaagatggg cctccagaac   1380

tcctgtttat tcatggagga cacactgcta agatttcaga ttttagctgg aaccccaatg   1440

agccttgggt catttgctca gtgtctgagg ataacatcat gcagatatgg caaatggctg   1500

aaaatattta caatgatgaa gagtcagatg tcacgacatc cgaactggag ggacaaggat   1560

cttaaaccca aagtacgaga aatgtttctg ttgaatgtaa tgctacatga atgcttgatt   1620

tatcaagcgc caaaaaggca ttgtatagta ggaaatgtaa gtggggtggc ttatggcttc   1680

tttatcctct gattctagca ctttcaagtg agctgttgcg tactgtatca tattgtagct   1740

attagggaag agaagaatgt tgcttaagaa agaacatcac cattgatttt aaatacaagt   1800

agcagggtat tgcctttgat tcaactgttt taagtcctca ttttctcaaa ctaagtgctt   1860

gctgttccca aatatgcaag aataactttt acactttttc cttccaacac ttcttgattg   1920

gctttgcaga aataaagttt taaaat                                        1946


<210>  4129
<211>  425
<212>  PRT
<213>  Homosapiens

<400>  4129

Met Ala Ser Lys Glu Met Phe Glu Asp Thr Val Glu Glu Arg Val Ile 
1               5                   10                  15      


Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr Asp 
            20                  25                  30          


Leu Val Met Thr His Ala Leu Gln Trp Pro Ser Leu Thr Val Gln Trp 
        35                  40                  45              


Leu Pro Glu Val Thr Lys Pro Glu Gly Lys Asp Tyr Ala Leu His Trp 
    50                  55                  60                  


Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val Val 
65                  70                  75                  80  


Ala Arg Val His Ile Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser His 
                85                  90                  95      


Cys Asp Ser Asp Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Thr Gly 
            100                 105                 110         


Lys Ile Glu Cys Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn Arg 
        115                 120                 125             


Ala Arg Tyr Met Pro Gln Asn Pro His Ile Ile Ala Thr Lys Thr Pro 
    130                 135                 140                 


Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ala Lys Pro 
145                 150                 155                 160 


Asp Pro Ser Gly Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His Gln 
                165                 170                 175     


Lys Glu Gly Tyr Gly Leu Ser Trp Asn Ser Asn Leu Ser Gly His Leu 
            180                 185                 190         


Leu Ser Ala Ser Asp Asp His Thr Val Cys Leu Trp Asp Ile Asn Ala 
        195                 200                 205             


Gly Pro Lys Glu Gly Lys Ile Val Asp Ala Lys Ala Ile Phe Thr Gly 
    210                 215                 220                 


His Ser Ala Val Val Glu Asp Val Ala Trp His Leu Leu His Glu Ser 
225                 230                 235                 240 


Leu Phe Gly Ser Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp Thr 
                245                 250                 255     


Arg Ser Asn Thr Thr Ser Lys Pro Ser His Leu Val Asp Ala His Thr 
            260                 265                 270         


Ala Glu Val Asn Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile Leu 
        275                 280                 285             


Ala Thr Gly Ser Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg Asn 
    290                 295                 300                 


Leu Lys Leu Lys Leu His Thr Phe Glu Ser His Lys Asp Glu Ile Phe 
305                 310                 315                 320 


Gln Val His Trp Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser Gly 
                325                 330                 335     


Thr Asp Arg Arg Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu Glu 
            340                 345                 350         


Gln Ser Ala Glu Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe Ile 
        355                 360                 365             


His Gly Gly His Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro Asn 
    370                 375                 380                 


Glu Pro Trp Val Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln Ile 
385                 390                 395                 400 


Trp Gln Met Ala Glu Asn Ile Tyr Asn Asp Glu Glu Ser Asp Val Thr 
                405                 410                 415     


Thr Ser Glu Leu Glu Gly Gln Gly Ser 
            420                 425 


<210>  4130
<211>  2285
<212>  DNA
<213>  Homosapiens

<400>  4130
ccgggaggaa gcggccgcgc ggcagctgcg gggcgtgggg gtggtggtgg cggcggcggt     60

ggtggcggcg gcggcggcgg cggcagctga ggccgaggag gcggtggctg tggcggacgc    120

agcagcaccc cagctaggga tagggctccg ccgcgccccc ttgctggccc catggaggcg    180

gcagcggcgg cggcggcggc ggcagcggca gcggcagcgg cgggcggggg ctgtggctcc    240

gggccgccgc cgctgctgct gagcgagggc gagcagcagt gctactccga gctcttcgcg    300

cgctgtgccg gcgccgcggg cgggggcccc gggtctgggc cccccgaggc cgccagagtc    360

gcccccggca cggccactgc ggccgccggc cccgtggctg acctgtttcg ggcatcgcag    420

ctgcccgccg agacgctgca ccagatcaca gaactgtgtg gtgcaaagcg ggttggttat    480

tttggtccaa cacagtttta cattgccctg aaattaattg ctgcagcaca atctggcctc    540

ccggtacgga tagagagtat taaatgtgaa ttgcctctgc ctcgctttat gatgtcaaag    600

aatgatggtg agatacgatt tgggaaccca gctgagctgc atggaactaa ggttcagatt    660

ccatatttaa ctacagaaaa aaattccttc aaaagaatgg acgatgagga taaacagcag    720

gaaacacagt ctcccacgat gtcacccctc gcctcccctc cttcttcccc gcctcattac    780

cagagggtgc ccttgagcca tggctacagc aaactgcgga gcagcgcaga acagatgcat    840

ccagcacctt atgaagctag gcagcccctt gtccagcccg agggatcctc atcagggggc    900

ccaggaacca agccccttcg gcatcaggct tcccttatcc ggtccttttc agtggagagg    960

gaactacagg ataacagcag ttaccccgac gaaccctgga ggataacaga agaacagcgc   1020

gagtactatg tcaatcagtt ccgatccctt cagccagacc caagctcttt catttcaggt   1080

tctgtggcca agaacttctt caccaaatca aagctttcca ttccagaact ctcctatata   1140

tgggagctta gtgatgctga ctgtgatgga gccctgaccc tgcctgagtt ctgtgctgcg   1200

tttcatctca ttgtggctcg gaagaacggc tacccattgc ctgagggcct ccctccaact   1260

ctgcagccag aatacctgca ggcagctttt cctaagccca aatgggactg tcaattattt   1320

gattcttatt ctgagtcact gccggcaaat caacaacctc gtgacttgaa tcggatggag   1380

aagacatctg ttaaagacat ggctgacctt cctgtcccta accaggatgt aactagtgat   1440

gacaaacaag ctttgaaaag tactatcaat gaagccttac caaaggacgt gtctgaggat   1500

ccagcaactc ccaaggattc caacagtctc aaagcaagac caagatccag atcttactct   1560

agcacctcca tagaagaggc catgaaaagg ggcgaggacc ctcccacccc gccacctcgg   1620

ccacagaaaa cccattccag agcctcctcc ttggatctga ataaagtctt ccagcccagt   1680

gtgccagcta ccaagtcagg attgttaccc ccaccacctg cgctccctcc aagaccttgt   1740

ccatcacagt ctgaacaagt gtcggaggcc gagttactcc cacagctgag cagagcccca   1800

tcccaggctg cagaaagtag tccagcaaag aaggatgtac tgtattctca gccaccatca   1860

aagcccattc gtaggaaatt cagaccagaa aaccaagcta cagaaaacca agagccttcc   1920

actgctgcaa gtgggccagc ttctgcggca accatgaaac cgcatccaac agtccaaaag   1980

cagtcttcca aacagaagaa ggccattcaa actgctatcc gcaaaaataa agaggcaaac   2040

gcagtgctgg ctcggctgaa cagtgagctc cagcagcagc tcaaggaggt tcatcaagaa   2100

cgaattgcat tggaaaacca attggaacaa cttcgtccgg tcactgtgtt gtgacccccc   2160

catggttcaa gtgacagtgg gtgaccttgt ctgccaagat ctttcttttg aatgttttga   2220

acccaactac ttgtcataga tgtttgactg tgtcaaaagc tgtgagcagc aaaatataat   2280

ccata                                                               2285


<210>  4131
<211>  521
<212>  PRT
<213>  Homosapiens

<400>  4131

Met Met Ser Lys Asn Asp Gly Glu Ile Arg Phe Gly Asn Pro Ala Glu 
1               5                   10                  15      


Leu His Gly Thr Lys Val Gln Ile Pro Tyr Leu Thr Thr Glu Lys Asn 
            20                  25                  30          


Ser Phe Lys Arg Met Asp Asp Glu Asp Lys Gln Gln Glu Thr Gln Ser 
        35                  40                  45              


Pro Thr Met Ser Pro Leu Ala Ser Pro Pro Ser Ser Pro Pro His Tyr 
    50                  55                  60                  


Gln Arg Val Pro Leu Ser His Gly Tyr Ser Lys Leu Arg Ser Ser Ala 
65                  70                  75                  80  


Glu Gln Met His Pro Ala Pro Tyr Glu Ala Arg Gln Pro Leu Val Gln 
                85                  90                  95      


Pro Glu Gly Ser Ser Ser Gly Gly Pro Gly Thr Lys Pro Leu Arg His 
            100                 105                 110         


Gln Ala Ser Leu Ile Arg Ser Phe Ser Val Glu Arg Glu Leu Gln Asp 
        115                 120                 125             


Asn Ser Ser Tyr Pro Asp Glu Pro Trp Arg Ile Thr Glu Glu Gln Arg 
    130                 135                 140                 


Glu Tyr Tyr Val Asn Gln Phe Arg Ser Leu Gln Pro Asp Pro Ser Ser 
145                 150                 155                 160 


Phe Ile Ser Gly Ser Val Ala Lys Asn Phe Phe Thr Lys Ser Lys Leu 
                165                 170                 175     


Ser Ile Pro Glu Leu Ser Tyr Ile Trp Glu Leu Ser Asp Ala Asp Cys 
            180                 185                 190         


Asp Gly Ala Leu Thr Leu Pro Glu Phe Cys Ala Ala Phe His Leu Ile 
        195                 200                 205             


Val Ala Arg Lys Asn Gly Tyr Pro Leu Pro Glu Gly Leu Pro Pro Thr 
    210                 215                 220                 


Leu Gln Pro Glu Tyr Leu Gln Ala Ala Phe Pro Lys Pro Lys Trp Asp 
225                 230                 235                 240 


Cys Gln Leu Phe Asp Ser Tyr Ser Glu Ser Leu Pro Ala Asn Gln Gln 
                245                 250                 255     


Pro Arg Asp Leu Asn Arg Met Glu Lys Thr Ser Val Lys Asp Met Ala 
            260                 265                 270         


Asp Leu Pro Val Pro Asn Gln Asp Val Thr Ser Asp Asp Lys Gln Ala 
        275                 280                 285             


Leu Lys Ser Thr Ile Asn Glu Ala Leu Pro Lys Asp Val Ser Glu Asp 
    290                 295                 300                 


Pro Ala Thr Pro Lys Asp Ser Asn Ser Leu Lys Ala Arg Pro Arg Ser 
305                 310                 315                 320 


Arg Ser Tyr Ser Ser Thr Ser Ile Glu Glu Ala Met Lys Arg Gly Glu 
                325                 330                 335     


Asp Pro Pro Thr Pro Pro Pro Arg Pro Gln Lys Thr His Ser Arg Ala 
            340                 345                 350         


Ser Ser Leu Asp Leu Asn Lys Val Phe Gln Pro Ser Val Pro Ala Thr 
        355                 360                 365             


Lys Ser Gly Leu Leu Pro Pro Pro Pro Ala Leu Pro Pro Arg Pro Cys 
    370                 375                 380                 


Pro Ser Gln Ser Glu Gln Val Ser Glu Ala Glu Leu Leu Pro Gln Leu 
385                 390                 395                 400 


Ser Arg Ala Pro Ser Gln Ala Ala Glu Ser Ser Pro Ala Lys Lys Asp 
                405                 410                 415     


Val Leu Tyr Ser Gln Pro Pro Ser Lys Pro Ile Arg Arg Lys Phe Arg 
            420                 425                 430         


Pro Glu Asn Gln Ala Thr Glu Asn Gln Glu Pro Ser Thr Ala Ala Ser 
        435                 440                 445             


Gly Pro Ala Ser Ala Ala Thr Met Lys Pro His Pro Thr Val Gln Lys 
    450                 455                 460                 


Gln Ser Ser Lys Gln Lys Lys Ala Ile Gln Thr Ala Ile Arg Lys Asn 
465                 470                 475                 480 


Lys Glu Ala Asn Ala Val Leu Ala Arg Leu Asn Ser Glu Leu Gln Gln 
                485                 490                 495     


Gln Leu Lys Glu Val His Gln Glu Arg Ile Ala Leu Glu Asn Gln Leu 
            500                 505                 510         


Glu Gln Leu Arg Pro Val Thr Val Leu 
        515                 520     


<210>  4132
<211>  2142
<212>  DNA
<213>  Homosapiens

<400>  4132
gcagaaggtg acgggaaaca ggccgcagac ctgaacttcc aaccgtatgt aggcgagaag     60

ccggtgccga tactcccact atcccacaat gtcccactgg gccccagagt ggaagagggc    120

ggaggctaat ccaagagacc ttggggccag ctgggatgtc aggggcagca gaggcagtgg    180

ctggagtggc cccttcggcc atcagggacc gagagcagca ggctcccgtg aaccaccact    240

ctgctttaaa ataaagaaca atatggttgg tgtggtcatt ggttacagtg gatcaaaaat    300

aaaagatcta caacattcga caaacactaa aatacagatc ataaacgggg aatctgaagc    360

aaaagtcaga atttttggca atagggaaat gaaagcaaag gccaaagcgg ctatagaaac    420

acttattaga aaacaagaaa gctacaactc agaatccagt gtggataatg ctgcatccca    480

aacccctatt ggaagaaatc taggcagaaa tgacattgtt ggagaagctg agccattgtc    540

aaattgggat cgcattaggg cagcagtcgt ggagtgcgaa aagagaaaat gggcagatct    600

accaccagtt aagaaaaact tttacataga atccaaagca acaagctgca tgtctgaaat    660

gcaggtgatt aactggagaa aggaaaattt caacataacg tgtgatgact tgaaaagtgg    720

tgaaaagcgt ctcattccaa aaccaacttg caggtttaaa gacgcttttc agcaataccc    780

tgatcttctg aaaagcataa taagggtagg gattgtaaag ccaacgccaa ttcagtcaca    840

ggcatggcca attattctac aaggaataga tcttatagta gttgcacaaa ccggaacagg    900

gaaaacattg tcctatctaa tgcctgggtt tattcatctt gattctcaac caatatctag    960

agagcaaagg aatgggcctg ggatgctagt ccttacaccc actagagagt tggctcttca   1020

cgtggaagct gaatgttcaa agtattcata taaaggtctc aaaagcattt gcatatatgg   1080

tggtagaaac agaaatggac aaatagaaga cattagcaaa ggtgtagata tcattattgc   1140

aactcctggg aggctgaatg acctacaaat gaataactct gtcaacctaa gaagcataac   1200

ctacttggtt atagatgagg cagataaaat gctggatatg gaatttgaac cccagataag   1260

gaagatttta ttagatgtgc gcccagaccg acagactgtt atgacaagtg caacttggcc   1320

agatactgta cgtcaactag cactttctta tttgaaagat cctatgattg tttatgttgg   1380

taatctgaat ctagtggctg taaatacagt gaagcaaaat ataattgtta ccacagaaaa   1440

agaaaaacga gctctcaccc aagaattcgt agagaacatg tcacccaacg acaaagtcat   1500

catgtttgtc agccaaaaac atattgctga tgacttgtca agcgacttca atatccaagg   1560

catatctgca gaatcattac atggcaacag tgaacagagt gatcaagagc gagcagtaga   1620

ggactttaaa agcggaaaca taaagatact gattacaact gatatagtat cccgaggtct   1680

tgatcttaat gatgtcacac atgtatataa ttatgatttc ccaaggaata ttgacgtata   1740

tgtacacaga gtagggtaca ttggacggac aggaaagact ggcacatcag ttaccctcat   1800

cactcagaga gattcgaaaa tggccggtga attgattaaa attctggaca gagcaaatca   1860

gagtgttccg gaagatcttg tagtaatggc tgagcaatac aagttaaatc aacaaaagag   1920

gcacagagaa acacgatcaa gaaaacctgg acaaagacgc aaggagtttt attttttaag   1980

ttgaaaagtt gtaccaggct actggaagat tccaggcatg ttaaagatat gcagtattga   2040

atatatgtaa ggaagtattg gaaacatact agccatttga agacataact aattcttaaa   2100

taatactgct aaactttcaa aaaaaaaaaa aaaaaaaaaa aa                      2142


<210>  4133
<211>  631
<212>  PRT
<213>  Homosapiens

<400>  4133

Met Ser His Trp Ala Pro Glu Trp Lys Arg Ala Glu Ala Asn Pro Arg 
1               5                   10                  15      


Asp Leu Gly Ala Ser Trp Asp Val Arg Gly Ser Arg Gly Ser Gly Trp 
            20                  25                  30          


Ser Gly Pro Phe Gly His Gln Gly Pro Arg Ala Ala Gly Ser Arg Glu 
        35                  40                  45              


Pro Pro Leu Cys Phe Lys Ile Lys Asn Asn Met Val Gly Val Val Ile 
    50                  55                  60                  


Gly Tyr Ser Gly Ser Lys Ile Lys Asp Leu Gln His Ser Thr Asn Thr 
65                  70                  75                  80  


Lys Ile Gln Ile Ile Asn Gly Glu Ser Glu Ala Lys Val Arg Ile Phe 
                85                  90                  95      


Gly Asn Arg Glu Met Lys Ala Lys Ala Lys Ala Ala Ile Glu Thr Leu 
            100                 105                 110         


Ile Arg Lys Gln Glu Ser Tyr Asn Ser Glu Ser Ser Val Asp Asn Ala 
        115                 120                 125             


Ala Ser Gln Thr Pro Ile Gly Arg Asn Leu Gly Arg Asn Asp Ile Val 
    130                 135                 140                 


Gly Glu Ala Glu Pro Leu Ser Asn Trp Asp Arg Ile Arg Ala Ala Val 
145                 150                 155                 160 


Val Glu Cys Glu Lys Arg Lys Trp Ala Asp Leu Pro Pro Val Lys Lys 
                165                 170                 175     


Asn Phe Tyr Ile Glu Ser Lys Ala Thr Ser Cys Met Ser Glu Met Gln 
            180                 185                 190         


Val Ile Asn Trp Arg Lys Glu Asn Phe Asn Ile Thr Cys Asp Asp Leu 
        195                 200                 205             


Lys Ser Gly Glu Lys Arg Leu Ile Pro Lys Pro Thr Cys Arg Phe Lys 
    210                 215                 220                 


Asp Ala Phe Gln Gln Tyr Pro Asp Leu Leu Lys Ser Ile Ile Arg Val 
225                 230                 235                 240 


Gly Ile Val Lys Pro Thr Pro Ile Gln Ser Gln Ala Trp Pro Ile Ile 
                245                 250                 255     


Leu Gln Gly Ile Asp Leu Ile Val Val Ala Gln Thr Gly Thr Gly Lys 
            260                 265                 270         


Thr Leu Ser Tyr Leu Met Pro Gly Phe Ile His Leu Asp Ser Gln Pro 
        275                 280                 285             


Ile Ser Arg Glu Gln Arg Asn Gly Pro Gly Met Leu Val Leu Thr Pro 
    290                 295                 300                 


Thr Arg Glu Leu Ala Leu His Val Glu Ala Glu Cys Ser Lys Tyr Ser 
305                 310                 315                 320 


Tyr Lys Gly Leu Lys Ser Ile Cys Ile Tyr Gly Gly Arg Asn Arg Asn 
                325                 330                 335     


Gly Gln Ile Glu Asp Ile Ser Lys Gly Val Asp Ile Ile Ile Ala Thr 
            340                 345                 350         


Pro Gly Arg Leu Asn Asp Leu Gln Met Asn Asn Ser Val Asn Leu Arg 
        355                 360                 365             


Ser Ile Thr Tyr Leu Val Ile Asp Glu Ala Asp Lys Met Leu Asp Met 
    370                 375                 380                 


Glu Phe Glu Pro Gln Ile Arg Lys Ile Leu Leu Asp Val Arg Pro Asp 
385                 390                 395                 400 


Arg Gln Thr Val Met Thr Ser Ala Thr Trp Pro Asp Thr Val Arg Gln 
                405                 410                 415     


Leu Ala Leu Ser Tyr Leu Lys Asp Pro Met Ile Val Tyr Val Gly Asn 
            420                 425                 430         


Leu Asn Leu Val Ala Val Asn Thr Val Lys Gln Asn Ile Ile Val Thr 
        435                 440                 445             


Thr Glu Lys Glu Lys Arg Ala Leu Thr Gln Glu Phe Val Glu Asn Met 
    450                 455                 460                 


Ser Pro Asn Asp Lys Val Ile Met Phe Val Ser Gln Lys His Ile Ala 
465                 470                 475                 480 


Asp Asp Leu Ser Ser Asp Phe Asn Ile Gln Gly Ile Ser Ala Glu Ser 
                485                 490                 495     


Leu His Gly Asn Ser Glu Gln Ser Asp Gln Glu Arg Ala Val Glu Asp 
            500                 505                 510         


Phe Lys Ser Gly Asn Ile Lys Ile Leu Ile Thr Thr Asp Ile Val Ser 
        515                 520                 525             


Arg Gly Leu Asp Leu Asn Asp Val Thr His Val Tyr Asn Tyr Asp Phe 
    530                 535                 540                 


Pro Arg Asn Ile Asp Val Tyr Val His Arg Val Gly Tyr Ile Gly Arg 
545                 550                 555                 560 


Thr Gly Lys Thr Gly Thr Ser Val Thr Leu Ile Thr Gln Arg Asp Ser 
                565                 570                 575     


Lys Met Ala Gly Glu Leu Ile Lys Ile Leu Asp Arg Ala Asn Gln Ser 
            580                 585                 590         


Val Pro Glu Asp Leu Val Val Met Ala Glu Gln Tyr Lys Leu Asn Gln 
        595                 600                 605             


Gln Lys Arg His Arg Glu Thr Arg Ser Arg Lys Pro Gly Gln Arg Arg 
    610                 615                 620                 


Lys Glu Phe Tyr Phe Leu Ser 
625                 630     


<210>  4134
<211>  2682
<212>  DNA
<213>  Homosapiens

<400>  4134
atctccatcc tgctcggcgc cagcttcagc cgctaccagg tcgaggagag cgtggagcac     60

ctgctggcgc cccagcacag cctggccaag atcgagcgca acctcgttaa cagcctcttc    120

ccggtcaacc gctccaagca ccgtctctac tcggacctgc agacccccgg gcgctacggc    180

cgggtcatcg tcacctcctt ccagaaagcc aacatgctgg accagcatca caccgacctg    240

atcttaaagt tgcatgctgc tgtcaccaag atccaggttc caaggcctgg ttttaattac    300

acgtttgccc atatatgtat cctgaataat gataagactt gcatcgtgga tgacatagtg    360

cacgtcctgg aagagctaaa gaatgctcgg gccaccaatc ggaccaattt tgctatcaca    420

tacccaatca cccacttaaa ggacgggagg gctgtgtaca atgggcacca gcttgggggc    480

gtcactgtgc acagcaaaga ccgggtgaaa tctgcagagg ccatccagct cacctactac    540

ctgcagtcaa tcaacagtct caatgacatg gtggctgaga ggtgggagtc cagcttctgc    600

gacactgtca gactgtttca gaaatccaac agcaaagtca aaatgtaccc ttacacgtcc    660

tcctcactga gggaagattt ccagaagacc agccgcgtat cagaacgtta cctggtcacc    720

agcctgattc tggtggttac catggccatc ctgtgctgct ctatgcagga ctgcgtccgc    780

agcaaaccct ggctaggcct gctcggattg gtgaccataa gcctggccac tctcactgca    840

gccgggatca tcaatcttac tggtgggaaa tataattcca ccttcctggg agtccctttc    900

gtcatgctag gtcatggatt atatgggact tttgaaatgt tatcctcctg gaggaaaact    960

agagaagacc aacatgttaa agagagaact gcagcagtct atgcagactc catgctctcc   1020

ttttctctca ccactgccat gtacctggtc acctttggca taggggccag ccctttcacg   1080

aacattgagg cagccaggat tttctgctgc aattcctgta ttgcaatctt cttcaactac   1140

ctctatgtac tctcgtttta tggttccagc ctagtgttca ctggctacat agaaaacaat   1200

taccagcata gtatcttctg tagaaaagtc ccaaagcctg aggcattgca ggagaagccg   1260

gcatggtaca ggtttctcct gacggccaga ttcagtgagg acacggctga aggcgaggaa   1320

gcgaacactt acgagagtca cctattggta tgtttcctca aacgctatta ctgtgactgg   1380

ataaccaaca cctatgtcaa gccttttgta gttctctttt accttattta tatttccttt   1440

gccttaatgg gctatctgca ggtcagtgaa gggtcagacc ttagtaacat tgtagcaacc   1500

gcgacacaaa ccattgagta cactactgcc cagcaaaagt acttcagcaa ctacagtcct   1560

gtgattgggt tttacatata tgagtctata gaatactgga acactagtgt ccaagaagat   1620

gttctagaat acaccaaggg gtttgtgcgg atatcccggt ttgagagcta tttaaattac   1680

cttcggaaac tcaatgtatc cactggcttg cctaagaaaa atttcacaga catgttgagg   1740

aattcctttc tgaaagcccc tcaattttca cattttcaag aggacatcat cttctctaaa   1800

aaatacaatg atgaggtcga tgtagtggcc tccagaatgt ttttggtggc caagaccatg   1860

gaaacaaaca gagaagaact ctatgatctc ttggaaaccc tgaggagact ttctgtcacc   1920

tccaaggtga agttcatcgt cttcaatccg tcctttgtat acatggatcg atatgcctcc   1980

tctctgggag cccccctgca caactcctgc atcagtgctt tgttcctgct cttcttctcg   2040

gcattcctgg tggcagattc actgattaac gtctggatca ctctcacagt tgtgtccgtg   2100

gagtttggag tgataggttt catgacatta tggaaagtag aactggactg catttctgtg   2160

ctatgcttaa tttatggaat taattacaca attgacaatt gtgctccaat gttatccgca   2220

tttgttctgg gcaaggattt cacaagaact aaatgggtaa aaaatgccct ggaagtgcat   2280

ggggtagcta ttttacagag ttacctctgc tatattgttg gtctgattcc tcttgcagct   2340

gtgccttcaa atctgacctg tacactgttc aggtgcttgt ttttaatagc atttgtcacc   2400

ttctttcact gctttgccat tttacctgtg atactgactt tcctgccacc ctctaagaaa   2460

aaaaggaaag agaagaaaaa tcctgagaac cgggaggaaa ttgagtgtgt agaaatggta   2520

gatatcgata gtacccgtgt ggttgaccaa attacaacag tgtgataatg tctgcttggc   2580

atattttcac cttaggtctt atcaagacca aagagattat gttaatgaaa caattaaatt   2640

caaagttctt ccctttttta aagataggaa acaggcattg cc                      2682


<210>  4135
<211>  783
<212>  PRT
<213>  Homosapiens

<400>  4135

Met Leu Asp Gln His His Thr Asp Leu Ile Leu Lys Leu His Ala Ala 
1               5                   10                  15      


Val Thr Lys Ile Gln Val Pro Arg Pro Gly Phe Asn Tyr Thr Phe Ala 
            20                  25                  30          


His Ile Cys Ile Leu Asn Asn Asp Lys Thr Cys Ile Val Asp Asp Ile 
        35                  40                  45              


Val His Val Leu Glu Glu Leu Lys Asn Ala Arg Ala Thr Asn Arg Thr 
    50                  55                  60                  


Asn Phe Ala Ile Thr Tyr Pro Ile Thr His Leu Lys Asp Gly Arg Ala 
65                  70                  75                  80  


Val Tyr Asn Gly His Gln Leu Gly Gly Val Thr Val His Ser Lys Asp 
                85                  90                  95      


Arg Val Lys Ser Ala Glu Ala Ile Gln Leu Thr Tyr Tyr Leu Gln Ser 
            100                 105                 110         


Ile Asn Ser Leu Asn Asp Met Val Ala Glu Arg Trp Glu Ser Ser Phe 
        115                 120                 125             


Cys Asp Thr Val Arg Leu Phe Gln Lys Ser Asn Ser Lys Val Lys Met 
    130                 135                 140                 


Tyr Pro Tyr Thr Ser Ser Ser Leu Arg Glu Asp Phe Gln Lys Thr Ser 
145                 150                 155                 160 


Arg Val Ser Glu Arg Tyr Leu Val Thr Ser Leu Ile Leu Val Val Thr 
                165                 170                 175     


Met Ala Ile Leu Cys Cys Ser Met Gln Asp Cys Val Arg Ser Lys Pro 
            180                 185                 190         


Trp Leu Gly Leu Leu Gly Leu Val Thr Ile Ser Leu Ala Thr Leu Thr 
        195                 200                 205             


Ala Ala Gly Ile Ile Asn Leu Thr Gly Gly Lys Tyr Asn Ser Thr Phe 
    210                 215                 220                 


Leu Gly Val Pro Phe Val Met Leu Gly His Gly Leu Tyr Gly Thr Phe 
225                 230                 235                 240 


Glu Met Leu Ser Ser Trp Arg Lys Thr Arg Glu Asp Gln His Val Lys 
                245                 250                 255     


Glu Arg Thr Ala Ala Val Tyr Ala Asp Ser Met Leu Ser Phe Ser Leu 
            260                 265                 270         


Thr Thr Ala Met Tyr Leu Val Thr Phe Gly Ile Gly Ala Ser Pro Phe 
        275                 280                 285             


Thr Asn Ile Glu Ala Ala Arg Ile Phe Cys Cys Asn Ser Cys Ile Ala 
    290                 295                 300                 


Ile Phe Phe Asn Tyr Leu Tyr Val Leu Ser Phe Tyr Gly Ser Ser Leu 
305                 310                 315                 320 


Val Phe Thr Gly Tyr Ile Glu Asn Asn Tyr Gln His Ser Ile Phe Cys 
                325                 330                 335     


Arg Lys Val Pro Lys Pro Glu Ala Leu Gln Glu Lys Pro Ala Trp Tyr 
            340                 345                 350         


Arg Phe Leu Leu Thr Ala Arg Phe Ser Glu Asp Thr Ala Glu Gly Glu 
        355                 360                 365             


Glu Ala Asn Thr Tyr Glu Ser His Leu Leu Val Cys Phe Leu Lys Arg 
    370                 375                 380                 


Tyr Tyr Cys Asp Trp Ile Thr Asn Thr Tyr Val Lys Pro Phe Val Val 
385                 390                 395                 400 


Leu Phe Tyr Leu Ile Tyr Ile Ser Phe Ala Leu Met Gly Tyr Leu Gln 
                405                 410                 415     


Val Ser Glu Gly Ser Asp Leu Ser Asn Ile Val Ala Thr Ala Thr Gln 
            420                 425                 430         


Thr Ile Glu Tyr Thr Thr Ala Gln Gln Lys Tyr Phe Ser Asn Tyr Ser 
        435                 440                 445             


Pro Val Ile Gly Phe Tyr Ile Tyr Glu Ser Ile Glu Tyr Trp Asn Thr 
    450                 455                 460                 


Ser Val Gln Glu Asp Val Leu Glu Tyr Thr Lys Gly Phe Val Arg Ile 
465                 470                 475                 480 


Ser Arg Phe Glu Ser Tyr Leu Asn Tyr Leu Arg Lys Leu Asn Val Ser 
                485                 490                 495     


Thr Gly Leu Pro Lys Lys Asn Phe Thr Asp Met Leu Arg Asn Ser Phe 
            500                 505                 510         


Leu Lys Ala Pro Gln Phe Ser His Phe Gln Glu Asp Ile Ile Phe Ser 
        515                 520                 525             


Lys Lys Tyr Asn Asp Glu Val Asp Val Val Ala Ser Arg Met Phe Leu 
    530                 535                 540                 


Val Ala Lys Thr Met Glu Thr Asn Arg Glu Glu Leu Tyr Asp Leu Leu 
545                 550                 555                 560 


Glu Thr Leu Arg Arg Leu Ser Val Thr Ser Lys Val Lys Phe Ile Val 
                565                 570                 575     


Phe Asn Pro Ser Phe Val Tyr Met Asp Arg Tyr Ala Ser Ser Leu Gly 
            580                 585                 590         


Ala Pro Leu His Asn Ser Cys Ile Ser Ala Leu Phe Leu Leu Phe Phe 
        595                 600                 605             


Ser Ala Phe Leu Val Ala Asp Ser Leu Ile Asn Val Trp Ile Thr Leu 
    610                 615                 620                 


Thr Val Val Ser Val Glu Phe Gly Val Ile Gly Phe Met Thr Leu Trp 
625                 630                 635                 640 


Lys Val Glu Leu Asp Cys Ile Ser Val Leu Cys Leu Ile Tyr Gly Ile 
                645                 650                 655     


Asn Tyr Thr Ile Asp Asn Cys Ala Pro Met Leu Ser Ala Phe Val Leu 
            660                 665                 670         


Gly Lys Asp Phe Thr Arg Thr Lys Trp Val Lys Asn Ala Leu Glu Val 
        675                 680                 685             


His Gly Val Ala Ile Leu Gln Ser Tyr Leu Cys Tyr Ile Val Gly Leu 
    690                 695                 700                 


Ile Pro Leu Ala Ala Val Pro Ser Asn Leu Thr Cys Thr Leu Phe Arg 
705                 710                 715                 720 


Cys Leu Phe Leu Ile Ala Phe Val Thr Phe Phe His Cys Phe Ala Ile 
                725                 730                 735     


Leu Pro Val Ile Leu Thr Phe Leu Pro Pro Ser Lys Lys Lys Arg Lys 
            740                 745                 750         


Glu Lys Lys Asn Pro Glu Asn Arg Glu Glu Ile Glu Cys Val Glu Met 
        755                 760                 765             


Val Asp Ile Asp Ser Thr Arg Val Val Asp Gln Ile Thr Thr Val 
    770                 775                 780             


<210>  4136
<211>  3624
<212>  DNA
<213>  Homosapiens

<400>  4136
cagtactgta caaggaaaac cccgtcggat ctgttattgc gggatacttg tgaaatatac     60

ataggattct ttcttatggc tgcatcccgg atctggaaat tttacttggg gaccaggagg    120

atttgaaagg ctgcatgtac tcagaagatt tgcaagcaac actccaattc ttgtcataga    180

gctcgcagac ttctcactta tcggcttttt tccttcctta ttttttaaga attattctta    240

ttttcccctc tctttttctg ctctctcctc tctcagtctc tccttttcta tctgcctctt    300

catttttctc ctagtctgtt tttttttttc ctgctctgca cctggattgt atcttcagca    360

aacaatcggg cactttgaga actaactgga gacagtcttg tagggaagat ctgtatggaa    420

ttatctgctt ttatggtgaa cttggcattt gtgaatggga atcttgttca caatattaat    480

tgctagcaaa aacaagaaaa agaacacagg agtaaaacgt ggatttttct gaatacgcat    540

tgtgatgacc agcaattacc ttaccgacta atatccagag gagaataatt tggaagactg    600

ttgtggggaa cagcctttaa gagctggaag atgaaagctc cgattccaca cttgattctc    660

ttatacgcta cttttactca gagtttgaag gttgtgacca aaagaggctc cgccgatgga    720

tgcactgact ggtctatcga tatcaagaaa tatcaagttt tggtgggaga gcctgttcga    780

atcaaatgtg cactctttta tggttatatc agaacaaatt actcccttgc ccaaagtgct    840

ggactcagtt tgatgtggta caaaagttct ggtcctggag actttgaaga gccaatagcc    900

tttgacggaa gtagaatgag caaagaagaa gactccattt ggttccggcc aacattgcta    960

caggacagtg gtctctacgc ctgtgtcatc agaaactcca cttactgtat gaaagtatcc   1020

atctcactga cagtgggtga aaatgacact ggactctgct ataattccaa gatgaagtat   1080

tttgaaaaag ctgaacttag caaaagcaag gaaatttcat gccgtgacat agaggatttt   1140

ctactgccaa ccagagaacc tgaaatcctt tggtacaagg aatgcaggac aaaaacatgg   1200

aggccaagta ttgtattcaa aagagatact ctgcttataa gagaagtcag agaagatgac   1260

attggaaatt atacctgtga attaaaatat ggaggctttg ttgtgagaag aactactgaa   1320

ttaactgtta cagcccctct gactgataag ccacccaagc ttttgtatcc tatggaaagt   1380

aaactgacaa ttcaggagac ccagctgggt gactctgcta atctaacctg cagagctttc   1440

tttgggtaca gcggagatgt cagtccttta atttactgga tgaaaggaga aaaatttatt   1500

gaagatctgg atgaaaatcg agtttgggaa agtgacatta gaattcttaa ggagcatctt   1560

ggggaacagg aagtttccat ctcattaatt gtggactctg tggaagaagg tgacttggga   1620

aattactcct gttatgttga aaatggaaat ggacgtcgac acgccagcgt tctccttcat   1680

aaacgagagc taatgtacac agtggaactt gctggaggcc ttggtgctat actcttgctg   1740

cttgtatgtt tggtgaccat ctacaagtgt tacaagatag aaatcatgct cttctacagg   1800

aatcattttg gagctgaaga gctcgatgga gacaataaag attatgatgc atacttatca   1860

tacaccaaag tggatcctga ccagtggaat caagagactg gggaagaaga acgttttgcc   1920

cttgaaatcc tacctgatat gcttgaaaag cattatggat ataagttgtt tataccagat   1980

agagatttaa tcccaactgg aacatacatt gaagatgtgg caagatgtgt agatcaaagc   2040

aagcggctga ttattgtcat gaccccaaat tacgtagtta gaaggggctg gagcatcttt   2100

gagctggaaa ccagacttcg aaatatgctt gtgactggag aaattaaagt gattctaatt   2160

gaatgcagtg aactgagagg aattatgaac taccaggagg tggaggccct gaagcacacc   2220

atcaagctcc tgacggtcat taaatggcat ggaccaaaat gcaacaagtt gaactccaag   2280

ttctggaaac gtttacagta tgaaatgcct tttaagagga tagaacccat tacacatgag   2340

caggctttag atgtcagtga gcaagggcct tttggggagc tgcagactgt ctcggccatt   2400

tccatggccg cggccacctc cacagctcta gccactgccc atccagatct ccgttctacc   2460

tttcacaaca cgtaccattc acaaatgcgt cagaaacact actaccgaag ctatgagtac   2520

gacgtacctc ctaccggcac cctgcctctt acctccatag gcaatcagca tacctactgt   2580

aacatcccta tgacactcat caacgggcag cggccacaga caaaatcgag cagggagcag   2640

aatccagatg aggcccacac aaacagtgcc atcctgccgc tgttgccaag ggagaccagt   2700

atatccagtg tgatatggtg acagaaaagc aagggacatc ccgtccctgg gaggttgagt   2760

ggaatctgca gtccagtgcc tggaactaaa tcctcgactg ctgctgttaa aaaacatgca   2820

ttagaatctc tagaacacga ggaaaaacag ggtcttgtac atatgttttt tggaatttct   2880

ttgtagcatc agtgtcctcc tgttttacca tgtcttttac cattacattt tttgactttg   2940

ttttatatgt cgttggaatt tgtaaattta catttttttt aaagaagaga ctgatgtgta   3000

gatagaaaac cctttttttg cttcattagt ttagttttag aatgggtttt tattttattt   3060

ccttttttaa aattttactt tgcttttaac atttccttgg ggtgcttgga caaatctatc   3120

cgatgggaca aggagcaccg gattctttct cgggttctgc ctagcatcaa ctgggccacg   3180

tcggccttca gagaacagtg caacaaatgc cagcattgcc attcggggga aaaaaaaaaa   3240

aaaaaaaaaa agatgagaag aacacttgtt cataggaggg ccccaccagt cagagccctg   3300

aatctcttcc ttgtcccacc tcattcccca cctctacctt tctaatggcg gcatgatgtg   3360

taaactctgt gcaggggtgg gggcgggtct aactgtctta acattcaagt cactgctctt   3420

cagaatacac tctagaccca aaggtgtgct aatcacttca cagtgaccac tacagagtac   3480

taagaagaga agatcaaggg catgaaattg gggaagagtg ttatttccgt tttttaaatg   3540

agttgatgta cccttatata tatatacata tatatataaa tataaatata tataaaaaca   3600

acaaaacaaa acaaaaaaag aaaa                                          3624


<210>  4137
<211>  696
<212>  PRT
<213>  Homosapiens

<400>  4137

Met Lys Ala Pro Ile Pro His Leu Ile Leu Leu Tyr Ala Thr Phe Thr 
1               5                   10                  15      


Gln Ser Leu Lys Val Val Thr Lys Arg Gly Ser Ala Asp Gly Cys Thr 
            20                  25                  30          


Asp Trp Ser Ile Asp Ile Lys Lys Tyr Gln Val Leu Val Gly Glu Pro 
        35                  40                  45              


Val Arg Ile Lys Cys Ala Leu Phe Tyr Gly Tyr Ile Arg Thr Asn Tyr 
    50                  55                  60                  


Ser Leu Ala Gln Ser Ala Gly Leu Ser Leu Met Trp Tyr Lys Ser Ser 
65                  70                  75                  80  


Gly Pro Gly Asp Phe Glu Glu Pro Ile Ala Phe Asp Gly Ser Arg Met 
                85                  90                  95      


Ser Lys Glu Glu Asp Ser Ile Trp Phe Arg Pro Thr Leu Leu Gln Asp 
            100                 105                 110         


Ser Gly Leu Tyr Ala Cys Val Ile Arg Asn Ser Thr Tyr Cys Met Lys 
        115                 120                 125             


Val Ser Ile Ser Leu Thr Val Gly Glu Asn Asp Thr Gly Leu Cys Tyr 
    130                 135                 140                 


Asn Ser Lys Met Lys Tyr Phe Glu Lys Ala Glu Leu Ser Lys Ser Lys 
145                 150                 155                 160 


Glu Ile Ser Cys Arg Asp Ile Glu Asp Phe Leu Leu Pro Thr Arg Glu 
                165                 170                 175     


Pro Glu Ile Leu Trp Tyr Lys Glu Cys Arg Thr Lys Thr Trp Arg Pro 
            180                 185                 190         


Ser Ile Val Phe Lys Arg Asp Thr Leu Leu Ile Arg Glu Val Arg Glu 
        195                 200                 205             


Asp Asp Ile Gly Asn Tyr Thr Cys Glu Leu Lys Tyr Gly Gly Phe Val 
    210                 215                 220                 


Val Arg Arg Thr Thr Glu Leu Thr Val Thr Ala Pro Leu Thr Asp Lys 
225                 230                 235                 240 


Pro Pro Lys Leu Leu Tyr Pro Met Glu Ser Lys Leu Thr Ile Gln Glu 
                245                 250                 255     


Thr Gln Leu Gly Asp Ser Ala Asn Leu Thr Cys Arg Ala Phe Phe Gly 
            260                 265                 270         


Tyr Ser Gly Asp Val Ser Pro Leu Ile Tyr Trp Met Lys Gly Glu Lys 
        275                 280                 285             


Phe Ile Glu Asp Leu Asp Glu Asn Arg Val Trp Glu Ser Asp Ile Arg 
    290                 295                 300                 


Ile Leu Lys Glu His Leu Gly Glu Gln Glu Val Ser Ile Ser Leu Ile 
305                 310                 315                 320 


Val Asp Ser Val Glu Glu Gly Asp Leu Gly Asn Tyr Ser Cys Tyr Val 
                325                 330                 335     


Glu Asn Gly Asn Gly Arg Arg His Ala Ser Val Leu Leu His Lys Arg 
            340                 345                 350         


Glu Leu Met Tyr Thr Val Glu Leu Ala Gly Gly Leu Gly Ala Ile Leu 
        355                 360                 365             


Leu Leu Leu Val Cys Leu Val Thr Ile Tyr Lys Cys Tyr Lys Ile Glu 
    370                 375                 380                 


Ile Met Leu Phe Tyr Arg Asn His Phe Gly Ala Glu Glu Leu Asp Gly 
385                 390                 395                 400 


Asp Asn Lys Asp Tyr Asp Ala Tyr Leu Ser Tyr Thr Lys Val Asp Pro 
                405                 410                 415     


Asp Gln Trp Asn Gln Glu Thr Gly Glu Glu Glu Arg Phe Ala Leu Glu 
            420                 425                 430         


Ile Leu Pro Asp Met Leu Glu Lys His Tyr Gly Tyr Lys Leu Phe Ile 
        435                 440                 445             


Pro Asp Arg Asp Leu Ile Pro Thr Gly Thr Tyr Ile Glu Asp Val Ala 
    450                 455                 460                 


Arg Cys Val Asp Gln Ser Lys Arg Leu Ile Ile Val Met Thr Pro Asn 
465                 470                 475                 480 


Tyr Val Val Arg Arg Gly Trp Ser Ile Phe Glu Leu Glu Thr Arg Leu 
                485                 490                 495     


Arg Asn Met Leu Val Thr Gly Glu Ile Lys Val Ile Leu Ile Glu Cys 
            500                 505                 510         


Ser Glu Leu Arg Gly Ile Met Asn Tyr Gln Glu Val Glu Ala Leu Lys 
        515                 520                 525             


His Thr Ile Lys Leu Leu Thr Val Ile Lys Trp His Gly Pro Lys Cys 
    530                 535                 540                 


Asn Lys Leu Asn Ser Lys Phe Trp Lys Arg Leu Gln Tyr Glu Met Pro 
545                 550                 555                 560 


Phe Lys Arg Ile Glu Pro Ile Thr His Glu Gln Ala Leu Asp Val Ser 
                565                 570                 575     


Glu Gln Gly Pro Phe Gly Glu Leu Gln Thr Val Ser Ala Ile Ser Met 
            580                 585                 590         


Ala Ala Ala Thr Ser Thr Ala Leu Ala Thr Ala His Pro Asp Leu Arg 
        595                 600                 605             


Ser Thr Phe His Asn Thr Tyr His Ser Gln Met Arg Gln Lys His Tyr 
    610                 615                 620                 


Tyr Arg Ser Tyr Glu Tyr Asp Val Pro Pro Thr Gly Thr Leu Pro Leu 
625                 630                 635                 640 


Thr Ser Ile Gly Asn Gln His Thr Tyr Cys Asn Ile Pro Met Thr Leu 
                645                 650                 655     


Ile Asn Gly Gln Arg Pro Gln Thr Lys Ser Ser Arg Glu Gln Asn Pro 
            660                 665                 670         


Asp Glu Ala His Thr Asn Ser Ala Ile Leu Pro Leu Leu Pro Arg Glu 
        675                 680                 685             


Thr Ser Ile Ser Ser Val Ile Trp 
    690                 695     


<210>  4138
<211>  1626
<212>  DNA
<213>  Homosapiens

<400>  4138
acttccgctt tggaggcgag gacccgagcg agtgtagggg gtgcggcgtc tggtcagcca     60

ggggtgaatt ctcaggactg gtcggcagtc aagccatcat gcctcgtggt cagaagagta    120

agctccgtgc ccgtgagaaa cgccgcaagg cccgagatga gacccggggt ctcaatgttc    180

ctcaggtcac tgaagcagag gaagaagagg ccccctgctg ttcctcttct gtttctgggg    240

gtgctgcttc aagctctcct gctgctggca ttccccagaa gcctcagaga gccccaacca    300

ctgccgctgc tgcggctgcg ggtgtttcat ccacaaaatc taaaaaaggt gccaagagcc    360

accaaggtga gaaaaatgca agttcctccc aggcctcaac atctactaag agcccaagcg    420

aagatcctct aaccaggaag tcagggtcgt tggtgcagtt cctgttgtac aagtataaaa    480

taaaaaagtc cgttacaaag ggagaaatgc tgaaaattgt tggcaaaagg ttcagggagc    540

acttccctga gatcctcaag aaagcctctg agggcctcag tgttgtcttt ggccttgagc    600

tgaataaagt caaccccaac ggccacactt acaccttcat cgacaaggta gacctcactg    660

atgaggaatc cctgctcagt tcctgggact ttcccaggag aaagcttctg atgcctctcc    720

tgggtgtgat cttcttaaat ggcaactcag ctactgagga agagatctgg gaattcctga    780

atatgttggg agtctatgat ggagaggagc actcagtctt tggggaaccc tggaagctca    840

tcaccaaaga tctggtgcag gaaaaatatc tggagtacaa gcaggtgccc agcagtgatc    900

ccccacgctt tcaattcctg tggggtccga gagcctatgc tgaaaccagc aagatgaaag    960

tcctggagtt tttggccaag gtaaatggta ccaccccctg tgccttccca acccattacg   1020

aagaagcttt gaaagatgaa gagaaagccg gagtctgagc cagagttgta gccaggcctt   1080

gcactactgc catagccaat caatctccca aagccaagtt tacctgctgt tctcaccccc   1140

aatgaggtct taggcagatt ctttactttg taattcaaaa ggcctgttaa cctttgttct   1200

tgttatgcat gaataacttg ttgacttttt ttttttctct ttttcaacta gtgtttcaac   1260

aggtttattt agattcagaa tgtaaattta caaatgatat agatcaccct gttattgctg   1320

tttttcaggg acagtagaaa gtgttttgtt ttttgagtga aacaacttat taataaaaat   1380

ccttaaatca cttttgtaat ccaggacaag aaaatgtggc attagagtag aaatatcttt   1440

ggaaatgtga aagaccccat agtgaaatat ttgggatcag aagccagagg ggtaaaagtg   1500

gtcaattctt ggtttacttc atttaatctt tcttttcata aagatacata cctggatttg   1560

tttatgttat tcaagaatgt gtgagaaatt aaaccatagt tagttaaaaa aaaaaaaaaa   1620

aaaaaa                                                              1626


<210>  4139
<211>  319
<212>  PRT
<213>  Homosapiens

<400>  4139

Met Pro Arg Gly Gln Lys Ser Lys Leu Arg Ala Arg Glu Lys Arg Arg 
1               5                   10                  15      


Lys Ala Arg Asp Glu Thr Arg Gly Leu Asn Val Pro Gln Val Thr Glu 
            20                  25                  30          


Ala Glu Glu Glu Glu Ala Pro Cys Cys Ser Ser Ser Val Ser Gly Gly 
        35                  40                  45              


Ala Ala Ser Ser Ser Pro Ala Ala Gly Ile Pro Gln Lys Pro Gln Arg 
    50                  55                  60                  


Ala Pro Thr Thr Ala Ala Ala Ala Ala Ala Gly Val Ser Ser Thr Lys 
65                  70                  75                  80  


Ser Lys Lys Gly Ala Lys Ser His Gln Gly Glu Lys Asn Ala Ser Ser 
                85                  90                  95      


Ser Gln Ala Ser Thr Ser Thr Lys Ser Pro Ser Glu Asp Pro Leu Thr 
            100                 105                 110         


Arg Lys Ser Gly Ser Leu Val Gln Phe Leu Leu Tyr Lys Tyr Lys Ile 
        115                 120                 125             


Lys Lys Ser Val Thr Lys Gly Glu Met Leu Lys Ile Val Gly Lys Arg 
    130                 135                 140                 


Phe Arg Glu His Phe Pro Glu Ile Leu Lys Lys Ala Ser Glu Gly Leu 
145                 150                 155                 160 


Ser Val Val Phe Gly Leu Glu Leu Asn Lys Val Asn Pro Asn Gly His 
                165                 170                 175     


Thr Tyr Thr Phe Ile Asp Lys Val Asp Leu Thr Asp Glu Glu Ser Leu 
            180                 185                 190         


Leu Ser Ser Trp Asp Phe Pro Arg Arg Lys Leu Leu Met Pro Leu Leu 
        195                 200                 205             


Gly Val Ile Phe Leu Asn Gly Asn Ser Ala Thr Glu Glu Glu Ile Trp 
    210                 215                 220                 


Glu Phe Leu Asn Met Leu Gly Val Tyr Asp Gly Glu Glu His Ser Val 
225                 230                 235                 240 


Phe Gly Glu Pro Trp Lys Leu Ile Thr Lys Asp Leu Val Gln Glu Lys 
                245                 250                 255     


Tyr Leu Glu Tyr Lys Gln Val Pro Ser Ser Asp Pro Pro Arg Phe Gln 
            260                 265                 270         


Phe Leu Trp Gly Pro Arg Ala Tyr Ala Glu Thr Ser Lys Met Lys Val 
        275                 280                 285             


Leu Glu Phe Leu Ala Lys Val Asn Gly Thr Thr Pro Cys Ala Phe Pro 
    290                 295                 300                 


Thr His Tyr Glu Glu Ala Leu Lys Asp Glu Glu Lys Ala Gly Val 
305                 310                 315                 


<210>  4140
<211>  6507
<212>  DNA
<213>  Homosapiens

<400>  4140
ctgggtctca acggcagtgt ctcctaccag atcgtgccgt cgcaggtgcg ggacatgcct     60

gtcttcacct atgtctccat caatcccaac tcaggcgaca tctacgcgct gcgatccttt    120

aaccacgagc agaccaaggc gttcgaattc aaggtgctgg ccaaggacgg cggccttccc    180

tcattgcaaa gcaacgctac ggtgcgggtc atcatcctcg acgtcaacga caacaccccg    240

gtcatcacgg ccccacctct gattaacggc actgccgagg tctacatacc ccgcaactct    300

ggcataggct acctggtgac tgttgtcaag gcagaagact acgatgaggg cgaaaatggc    360

cgagtcacct acgacatgac cgagggcgac cgcggcttct ttgaaataga ccaggtcaat    420

ggcgaagtca gaaccacccg caccttcggg gagagctcca agtcctccta tgagcttatc    480

gtggtggctc acgaccacgg caagacatct ctctctgcct ctgctctcgt cctaatctac    540

ttgtcccctg ctctcgatgc ccaagagtca atgggctctg tgaacttgtc cttgattttc    600

attattgccc tgggctccat tgcgggcatc ctctttgtaa ctatgatctt cgtggcaatc    660

aagtgcaagc gagacaacaa agagatccgg acctacaact gcagaattgc tgagtactcc    720

tatgggcatc aaaagaaatc aagcaagaag aaaaaaatca gtaagaatga catccgcctg    780

gtaccccggg atgtggagga gacagacaag atgaacgttg tcagttgctc ttccctgacc    840

tcctccctca actattttga ctaccaccag cagacgctgc ccctgggctg ccgccgctct    900

gagagcactt tcctgaatgt ggagaaccag aatacccgca acaccagtgc taaccacatc    960

taccatcact ctttcaacag ccaggggccc cagcagcctg acctgattat caacggtgcg   1020

cctctgcctg agactgaaaa ctattctttt gactccaact acgtgaatag ccgagcccat   1080

ttaatcaaga gctccacctt caaggactta gagggcaaca gcctgaagga tagtggacat   1140

gaggagagtg accaaactga cagtgagcat gatgtccagc ggagcctgta ttgtgatact   1200

gctgtcaacg atgtgctgaa caccagtgtg acctccatgg gatctcagat gcctgatcat   1260

gatcagaatg aaggatttca ttgccgggaa gaatgccgga ttcttggcca ctctgacagg   1320

tgctggatgc cccggaaccc catgcccatc cgttccaagt cccctgagca tgtgaggaac   1380

atcatcgcgc tgtctattga agctactgct gctgatgtcg aggcttatga cgactgcggc   1440

cccaccaaac ggactttcgc aaccttcggg aaagatgtca gcgaccaccc ggctgaggag   1500

aggcctaccc tgaaaggcaa gaggactgtc gatgtgacca tctgcagccc caaggtcaac   1560

agcgttatcc gggaggcagg caatggctgt gaggcgatta gccctgtcac ctcccccctc   1620

cacctcaaga gctctctgcc caccaagcct tccgtgtctt acaccattgc cctggctccc   1680

ccagcccgtg atctggagca gtatgtcaac aatgtcaaca atggccctac tcgtccctct   1740

gaagctgagc cccgtggagc tgatagcgag aaagtcatgc atgaggtcag ccccattctg   1800

aaggaaggtc gcaacaaaga gtcccctggt gtgaagcgtc tgaaggatat cgttctctaa   1860

accagtctcc aggaagaaga gaaagaaacc acactggcta gtgaagaagc aggagcttct   1920

tgttttaatt gctcaccaat ggttggttct tgagtggcta tatttcagag cttttcctaa   1980

atgtattgtt tataggtgat tatcattctg tgacagtccc ttgtttcaac aggcagcagg   2040

ggtgttcagt tggagcaaat tagctttggc ttgagttgtt catggggcct tgatgttggg   2100

gaaacagaga caaattcagt tgtgaaaagt attatgtatt aagtgtttga atttatatat   2160

ttttctatgt caaaattata atataaatta ccattgtttg tggaggatta catttaaaaa   2220

agcaaaaagt gaaaaaaaaa agctctggac atctttaata agctcgccac tgttttttgt   2280

agtgtagaca agttaatggt catttattgt gtactattca ttgattcagt gatgtgaaat   2340

tgagccccca aaaggttgtt tctgaagctc gagtacttcc caatgccgct actttgctgt   2400

ggacacccct gctttaaaaa cccttttgct agctgtgcta ttgttgtatt tgatattgca   2460

aattgctatg tgtgtggtga tggcaaaagg cttttaaaag ttggtgtttt ctttttctta   2520

aaaaaataat aaaactacag acaaaaacaa agtgcaaaca actgagacag caaatgaatg   2580

agcaacacca tgcatataga ttgagtactt ggagaatact cacgtttttt aactcatgta   2640

gtgattgctc accactttgc aaagtatttt tcctgccttt cagtggtctg cccaggtcca   2700

tgatagatca ttgcagaaag tcatttttgg ataggctgct atctaatttg cagttgtcag   2760

aaatactgtg ctgaaagttt tatgacatcc atcttttaaa ttttcaggcc ctgaacagga   2820

aagttgctcc tgaagttatg tttccaggct tagaaattcc ctctctccaa tcatctaaaa   2880

ttgaagatga ctgaatctat tttaagatct aaattagcat ctcttcagac acacacttcc   2940

tgattcagtg tttcccaatc atgattagaa ttagactgca aagcacgtca tgggctggga   3000

ttgagaactc catgttgctc tgtatcttag gcttatatac gtagggatag agtaagcagt   3060

acaaagtgta tattttggaa aagacaggta acaggtaaca gcatcgctaa tccaattact   3120

gtgccttcta aacggagaca ctcagacact tgaactcatc tttttatgac taatagtttt   3180

ttgattaaaa atgtgaacaa gaaaatacta aaataaaaat cctttcgatt tagccaactc   3240

tttttgctgt aggctaggaa tacacccttt ttaaattaac acactgtaga tccttttttt   3300

ctgttttaac attcctctaa ctcccccatt tatcttttgt ctattaatat tcactagcca   3360

acatagtatt tttgcagcct aagagttcat tatttaaaaa taaactaaag aaatatgtca   3420

cctttgttct gccttggtct taagagagtt gtttctagag aaacaagttt tatggttctg   3480

ttttcatttg tttcattttt tgaaattcag gaatacacag agagaaggcc tagaggttag   3540

agcactagaa tgcaaaagag gatttatttt cttaagttta ggtagataag tcagctcttt   3600

tgaatgtttt acttattttt gcctgagttc ctagctttac gcattactag gaatattttc   3660

ttttacagga gggagaaggg ttttgaggga gggggtgggt aaggcagtag ggatggggtt   3720

aggtagggga gaacatttct gaaaaagaac ttataatgaa gctacaaatc catccttatt   3780

tcttattcag tgctgaatac tacctcatgc aaaatattgg tgtggctgca aatttccctc   3840

tgaagctgac acaattaagg atgaattacc ataacatctt catttttcct catttcattg   3900

cctctcatac agttttctcc ctctgattta tttcattttg gtagtggatt ttgaattaag   3960

tatttatttc tctttgcaag tgactatttg attaacacat taaaaatttt ttaaaaattt   4020

cccctttaag ttatgatggc tgcctataga atttagactg tttctcaccc tgatccatcc   4080

tgatattatg ttattagcta cgatttcaag gtcactttga agtcagactt cacagttttc   4140

tacaggtgta tttcttgcta tgctcagtgg gaaccaggga gcagaaaaga ttgtggaaag   4200

tgggaacatt aattgtcacg tggctgttga gccagagagg ccactggctg ccatgcctct   4260

taccagccaa gttttaaatg gttagagtgg cattggcatt gattttgctt ttctcttggg   4320

ttttcttcat ttcttttcat aattcatctt caagctatag atccatcctt cttccctatc   4380

caaatacttt gttctcagcg ggcagtcaga tttttttggc ttccaaacct cactgagcat   4440

gttcagagaa ttcctctcat taaggaaata tttttcccca caattgtctg atgtatgagt   4500

cctctcagaa gcacaagtgc atactaggaa ggctttgtaa actggttttg taggcaggct   4560

gtacctgcaa ataggcattc tgagcaagga tcctaaattt ccctttggct catgtccccc   4620

ccgccccacc ccaccttctc ctttttggca tgtctggtga aatgctacaa ggttcacagg   4680

gccaaatatt ctcccttttg ttctctaaac atgttgcaca cataaactca agggagtgat   4740

ttcggttcct aagtcctagg gagttctatt ccatttattc tgatgtccct tttaaggagg   4800

agttggtgtt gaagtgtgac atgctttaat gataactgct ttggcaattc cccagacagg   4860

tatacttctt catccaaaat tgcacctaag gtgttcattt agacaaaatt gttcgcttag   4920

tgatccactg atctctaatc agaaatattt ttaaaaaata caatttagat ctctgaaaat   4980

tggaaccact caagagtatc atcttgatag tgttacttca gcatatgact gactgatttt   5040

atgaagggag tttagctgac ttttccctgt agccctatca tattaaaaac aaaaagtggt   5100

ccacttgaag cagcaaggac aaagggcagt ttagggagag gcagggtgaa ggggatagct   5160

cgattgggca tccagagtgg aaaaggatta ttattgtaca taatagcagt tctggctgga   5220

attccaatcc actttctggg gatcattttg atgttgaatg ttcccccaaa gcattctgac   5280

aagtttggtc cacttggctc tttaccccgg gtaataagac ccttattgac tttgaaaaac   5340

tggcataaat gagcttaaga aatccattgt atacagtcct agtgtttgcc ttcttggtaa   5400

aattacattt aaggatgtca tttcatgagt caaattgtat ctgctgacac tgaagtgtat   5460

tgagatgttg ttctttagtt taagtatgta acaaagtaat attcaaaggg gatgtttggg   5520

ggtggggctg ggaccgggtg gctttatatt gataatgaaa tattccagag caaaacacat   5580

tgtcctaatg aagttgttgc agctctcttc gttttcttgt gccgctggaa ttggcttgtg   5640

ggtcacttgt tgtgcaaaag tgaattaatt tcaaatagga atcatattgc ttttgtgaaa   5700

caaagaaaat ttaccacctt gtctgataca tagattggaa ggcgctcttg gtaaagaata   5760

acccacaaac acctgatctt gattggaaag cattgtaggt cattagggaa aactgatgat   5820

gctgactgtt gctccagccg tgttggcaat tcaagatgac cttgttacta actgaaagtt   5880

gctgtcaacc ttagcaaaca aaccagctaa caccattaca gcactggtta agtagatttt   5940

tactggcact ggctggcgtt cagctgagga aggctaggat acagacttta atgaccaaga   6000

gccagactag ctcgagctag aaatcagcaa caaatacctc cttgtgctat ttgaatgcta   6060

aggtattagt tgcaataggc ttacgccttc gctcctctag tgaggggaat gagcctgatg   6120

acactattac tgtttacctg tcaaaccagg gtggaaattt agagggatgc aagtacagta   6180

tgtctcatta agcagtctct gttgctgatt atatgaagat aaaattgttg tatatgctga   6240

tctgtatgtt atgtacattt tcacagtgat tgaatcattg taaaaagaaa aaagacaaaa   6300

aagaatcacc actgtctatt ttatgaagat gataaagcag ctttattaaa ttattacagt   6360

tatgtttcaa atggtgttat ctgccacatt gtttcctttt atctggtggt tctctgtttc   6420

cccctttaaa tgtgttttct ctgcttcaaa aatttaatgc attttagtat taaaggctat   6480

tatggaaaaa gtaataaaaa aaaaaaa                                       6507


<210>  4141
<211>  601
<212>  PRT
<213>  Homosapiens

<400>  4141

Met Pro Val Phe Thr Tyr Val Ser Ile Asn Pro Asn Ser Gly Asp Ile 
1               5                   10                  15      


Tyr Ala Leu Arg Ser Phe Asn His Glu Gln Thr Lys Ala Phe Glu Phe 
            20                  25                  30          


Lys Val Leu Ala Lys Asp Gly Gly Leu Pro Ser Leu Gln Ser Asn Ala 
        35                  40                  45              


Thr Val Arg Val Ile Ile Leu Asp Val Asn Asp Asn Thr Pro Val Ile 
    50                  55                  60                  


Thr Ala Pro Pro Leu Ile Asn Gly Thr Ala Glu Val Tyr Ile Pro Arg 
65                  70                  75                  80  


Asn Ser Gly Ile Gly Tyr Leu Val Thr Val Val Lys Ala Glu Asp Tyr 
                85                  90                  95      


Asp Glu Gly Glu Asn Gly Arg Val Thr Tyr Asp Met Thr Glu Gly Asp 
            100                 105                 110         


Arg Gly Phe Phe Glu Ile Asp Gln Val Asn Gly Glu Val Arg Thr Thr 
        115                 120                 125             


Arg Thr Phe Gly Glu Ser Ser Lys Ser Ser Tyr Glu Leu Ile Val Val 
    130                 135                 140                 


Ala His Asp His Gly Lys Thr Ser Leu Ser Ala Ser Ala Leu Val Leu 
145                 150                 155                 160 


Ile Tyr Leu Ser Pro Ala Leu Asp Ala Gln Glu Ser Met Gly Ser Val 
                165                 170                 175     


Asn Leu Ser Leu Ile Phe Ile Ile Ala Leu Gly Ser Ile Ala Gly Ile 
            180                 185                 190         


Leu Phe Val Thr Met Ile Phe Val Ala Ile Lys Cys Lys Arg Asp Asn 
        195                 200                 205             


Lys Glu Ile Arg Thr Tyr Asn Cys Arg Ile Ala Glu Tyr Ser Tyr Gly 
    210                 215                 220                 


His Gln Lys Lys Ser Ser Lys Lys Lys Lys Ile Ser Lys Asn Asp Ile 
225                 230                 235                 240 


Arg Leu Val Pro Arg Asp Val Glu Glu Thr Asp Lys Met Asn Val Val 
                245                 250                 255     


Ser Cys Ser Ser Leu Thr Ser Ser Leu Asn Tyr Phe Asp Tyr His Gln 
            260                 265                 270         


Gln Thr Leu Pro Leu Gly Cys Arg Arg Ser Glu Ser Thr Phe Leu Asn 
        275                 280                 285             


Val Glu Asn Gln Asn Thr Arg Asn Thr Ser Ala Asn His Ile Tyr His 
    290                 295                 300                 


His Ser Phe Asn Ser Gln Gly Pro Gln Gln Pro Asp Leu Ile Ile Asn 
305                 310                 315                 320 


Gly Ala Pro Leu Pro Glu Thr Glu Asn Tyr Ser Phe Asp Ser Asn Tyr 
                325                 330                 335     


Val Asn Ser Arg Ala His Leu Ile Lys Ser Ser Thr Phe Lys Asp Leu 
            340                 345                 350         


Glu Gly Asn Ser Leu Lys Asp Ser Gly His Glu Glu Ser Asp Gln Thr 
        355                 360                 365             


Asp Ser Glu His Asp Val Gln Arg Ser Leu Tyr Cys Asp Thr Ala Val 
    370                 375                 380                 


Asn Asp Val Leu Asn Thr Ser Val Thr Ser Met Gly Ser Gln Met Pro 
385                 390                 395                 400 


Asp His Asp Gln Asn Glu Gly Phe His Cys Arg Glu Glu Cys Arg Ile 
                405                 410                 415     


Leu Gly His Ser Asp Arg Cys Trp Met Pro Arg Asn Pro Met Pro Ile 
            420                 425                 430         


Arg Ser Lys Ser Pro Glu His Val Arg Asn Ile Ile Ala Leu Ser Ile 
        435                 440                 445             


Glu Ala Thr Ala Ala Asp Val Glu Ala Tyr Asp Asp Cys Gly Pro Thr 
    450                 455                 460                 


Lys Arg Thr Phe Ala Thr Phe Gly Lys Asp Val Ser Asp His Pro Ala 
465                 470                 475                 480 


Glu Glu Arg Pro Thr Leu Lys Gly Lys Arg Thr Val Asp Val Thr Ile 
                485                 490                 495     


Cys Ser Pro Lys Val Asn Ser Val Ile Arg Glu Ala Gly Asn Gly Cys 
            500                 505                 510         


Glu Ala Ile Ser Pro Val Thr Ser Pro Leu His Leu Lys Ser Ser Leu 
        515                 520                 525             


Pro Thr Lys Pro Ser Val Ser Tyr Thr Ile Ala Leu Ala Pro Pro Ala 
    530                 535                 540                 


Arg Asp Leu Glu Gln Tyr Val Asn Asn Val Asn Asn Gly Pro Thr Arg 
545                 550                 555                 560 


Pro Ser Glu Ala Glu Pro Arg Gly Ala Asp Ser Glu Lys Val Met His 
                565                 570                 575     


Glu Val Ser Pro Ile Leu Lys Glu Gly Arg Asn Lys Glu Ser Pro Gly 
            580                 585                 590         


Val Lys Arg Leu Lys Asp Ile Val Leu 
        595                 600     


<210>  4142
<211>  1309
<212>  DNA
<213>  Homosapiens

<400>  4142
tatctatgta acaaatcgca gcacaggagt cccctgggct ccctcaggct ctggtatgac     60

atatttgagc catataaatt cagcttctcc tctggcatct gttagccgac tcacttgcaa    120

ctccacctca gcagtggtct ctcagtcctc tcaaagcaag gaaagagtac tgtgtgctga    180

gagaccatgg caaagaatcc tccagagaat tgtgaagact gtcacattct aaatgcagaa    240

gcttttaaat ccaagaaaat atgtaaatca cttaagattt gtggactggt gtttggtatc    300

ctgaccctaa ctctaattgt cctgttttgg gggagcaagc acttctggcc ggaggtaccc    360

aaaaaagcct atgacatgga gcacactttc tacagcagtg gagagaagaa gaagatttac    420

atggaaattg atcctgtgac cagaactgaa atattcagaa gcggaaatgg cactgatgaa    480

acattggaag tacacgactt taaaaacgga tacactggca tctacttcgt gggtcttcaa    540

aaatgtttta tcaaaactca gattaaagtg attcctgaat tttctgaacc agaagaggaa    600

atagatgaga atgaagaaat taccacaact ttctttgaac agtcagtgat ttgggtccca    660

gcagaaaagc ctattgaaaa ccgagatttt cttaaaaatt ccaaaattct ggagatttgt    720

gataacgtga ccatgtattg gatcaatccc actctaatat cagtttctga gttacaagac    780

tttgaggagg agggagaaga tcttcacttt cctgccaacg aaaaaaaagg gattgaacaa    840

aatgaacagt gggtggtccc tcaagtgaaa gtagagaaga cccgtcacgc cagacaagca    900

agtgaggaag aacttccaat aaatgactat actgaaaatg gaatagaatt tgatcccatg    960

ctggatgaga gaggttattg ttgtatttac tgccgtcgag gcaaccgcta ttgccgccgc   1020

gtctgtgaac ctttactagg ctactaccca tatccatact gctaccaagg aggacgagtc   1080

atctgtcgtg tcatcatgcc ttgtaactgg tgggtggccc gcatgctggg gagggtctaa   1140

taggaggttt gagctcaaat gcttaaactg ctggcaacat ataataaatg catgctattc   1200

aatgaatttc tgcctatgag gcatctggcc cctggtagcc agctctccag aattacttgt   1260

aggtaattcc tctcttcatg ttctaataaa cttctacatt atcaaaaaa               1309


<210>  4143
<211>  317
<212>  PRT
<213>  Homosapiens

<400>  4143

Met Ala Lys Asn Pro Pro Glu Asn Cys Glu Asp Cys His Ile Leu Asn 
1               5                   10                  15      


Ala Glu Ala Phe Lys Ser Lys Lys Ile Cys Lys Ser Leu Lys Ile Cys 
            20                  25                  30          


Gly Leu Val Phe Gly Ile Leu Thr Leu Thr Leu Ile Val Leu Phe Trp 
        35                  40                  45              


Gly Ser Lys His Phe Trp Pro Glu Val Pro Lys Lys Ala Tyr Asp Met 
    50                  55                  60                  


Glu His Thr Phe Tyr Ser Ser Gly Glu Lys Lys Lys Ile Tyr Met Glu 
65                  70                  75                  80  


Ile Asp Pro Val Thr Arg Thr Glu Ile Phe Arg Ser Gly Asn Gly Thr 
                85                  90                  95      


Asp Glu Thr Leu Glu Val His Asp Phe Lys Asn Gly Tyr Thr Gly Ile 
            100                 105                 110         


Tyr Phe Val Gly Leu Gln Lys Cys Phe Ile Lys Thr Gln Ile Lys Val 
        115                 120                 125             


Ile Pro Glu Phe Ser Glu Pro Glu Glu Glu Ile Asp Glu Asn Glu Glu 
    130                 135                 140                 


Ile Thr Thr Thr Phe Phe Glu Gln Ser Val Ile Trp Val Pro Ala Glu 
145                 150                 155                 160 


Lys Pro Ile Glu Asn Arg Asp Phe Leu Lys Asn Ser Lys Ile Leu Glu 
                165                 170                 175     


Ile Cys Asp Asn Val Thr Met Tyr Trp Ile Asn Pro Thr Leu Ile Ser 
            180                 185                 190         


Val Ser Glu Leu Gln Asp Phe Glu Glu Glu Gly Glu Asp Leu His Phe 
        195                 200                 205             


Pro Ala Asn Glu Lys Lys Gly Ile Glu Gln Asn Glu Gln Trp Val Val 
    210                 215                 220                 


Pro Gln Val Lys Val Glu Lys Thr Arg His Ala Arg Gln Ala Ser Glu 
225                 230                 235                 240 


Glu Glu Leu Pro Ile Asn Asp Tyr Thr Glu Asn Gly Ile Glu Phe Asp 
                245                 250                 255     


Pro Met Leu Asp Glu Arg Gly Tyr Cys Cys Ile Tyr Cys Arg Arg Gly 
            260                 265                 270         


Asn Arg Tyr Cys Arg Arg Val Cys Glu Pro Leu Leu Gly Tyr Tyr Pro 
        275                 280                 285             


Tyr Pro Tyr Cys Tyr Gln Gly Gly Arg Val Ile Cys Arg Val Ile Met 
    290                 295                 300                 


Pro Cys Asn Trp Trp Val Ala Arg Met Leu Gly Arg Val 
305                 310                 315         


<210>  4144
<211>  2069
<212>  DNA
<213>  Homosapiens

<400>  4144
cgctcgtaag ttttcggcag tttccgggga gactcgggga ctccgcgtct cgctctctgt     60

gttccaatcg cccggtgcgg tggtgcaggg tctcgggcta gtcatggcgt ccccgtctcg    120

gagactgcag actaaaccag tcattacttg tttcaagagc gttctgctaa tctacacttt    180

tattttctgg atcactggcg ttatccttct tgcagttggc atttggggca aggtgagcct    240

ggagaattac ttttctcttt taaatgagaa ggccaccaat gtccccttcg tgctcattgc    300

tactggtacc gtcattattc ttttgggcac ctttggttgt tttgctacct gccgagcttc    360

tgcatggatg ctaaaactgt atgcaatgtt tctgactctc gtttttttgg tcgaactggt    420

cgctgccatc gtaggatttg ttttcagaca tgagattaag aacagcttta agaataatta    480

tgagaaggct ttgaagcagt ataactctac aggagattat agaagccatg cagtagacaa    540

gatccaaaat acgttgcatt gttgtggtgt caccgattat agagattgga cagatactaa    600

ttattactca gaaaaaggat ttcctaagag ttgctgtaaa cttgaagatt gtactccaca    660

gagagatgca gacaaagtaa acaatgaagg ttgttttata aaggtgatga ccattataga    720

gtcagaaatg ggagtcgttg caggaatttc ctttggagtt gcttgcttcc aactgattgg    780

aatctttctc gcctactgcc tctctcgtgc cataacaaat aaccagtatg agatagtgta    840

acccaatgta tctgtgggcc tattcctctc tacctttaag gacatttagg gtcccccctg    900

tgaattagaa agttgcttgg ctggagaact gacaacacta cttactgata gaccaaaaaa    960

ctacaccagt aggttgattc aatcaagatg tatgtagacc taaaactaca ccaataggct   1020

gattcaatca agatccgtgc tcgcagtggg ctgattcaat caagatgtat gtttgctatg   1080

ttctaagtcc accttctatc ccattcatgt tagatcgttg aaaccctgta tccctctgaa   1140

acactggaag agctagtaaa ttgtaaatga agtaatactg tgttcctctt gactgttatt   1200

tttcttagta gggggccttt ggaaggcact gtgaatttgc tattttgatg tagtgttaca   1260

agatggaaaa ttgattcctc tgactttgct attgatgtag tgtgatagaa aattcacccc   1320

tctgaactgg ctccttccca gtcaaggtta tctggtttga ttgtataatt tgcaccaaga   1380

agttaaaatg ttttatgact ctctgttctg ctgacaggca gagagtcaca ttgtgtaatt   1440

taatttcagt cagtcaatag atggcatccc tcatcagggt tgccagatgg tgataacagt   1500

gtaaggcctt gggtctaagg catccacgac tggaagggac tactgatgtt ctgtgataca   1560

tcaggtttca gcacacaact tacatttctt tgcctccaaa ttgaggcatt tattatgatg   1620

ttcatacttt ccctcttgtt tgaaagtttc taattattaa atggtgtcgg aattgttgta   1680

ttttccttag gaattcagtg gaacttatct tcattaaatt tagctggtac caggttgata   1740

tgacttgtca atattatggt caactttaag tcttagtttt cgtttgtgcc tttgattaat   1800

aagtataact cttatacaat aaatactgct ttcctctaaa aagatcgtgt ttaaattaac   1860

ttgtagaaaa tctgctggaa tggttgttgt tttccactga gaaagctaag ccctacattt   1920

ctattcagag tactgttttt agatgtgaaa tataagcctg cggccttaac tctgtattaa   1980

aaaaaatgtt tttgtttaaa aaaaactgtt cccataggtg cagcaaacca ccatggcaca   2040

tgtataccta tgtaacaaac ctgcacatt                                     2069


<210>  4145
<211>  245
<212>  PRT
<213>  Homosapiens

<400>  4145

Met Ala Ser Pro Ser Arg Arg Leu Gln Thr Lys Pro Val Ile Thr Cys 
1               5                   10                  15      


Phe Lys Ser Val Leu Leu Ile Tyr Thr Phe Ile Phe Trp Ile Thr Gly 
            20                  25                  30          


Val Ile Leu Leu Ala Val Gly Ile Trp Gly Lys Val Ser Leu Glu Asn 
        35                  40                  45              


Tyr Phe Ser Leu Leu Asn Glu Lys Ala Thr Asn Val Pro Phe Val Leu 
    50                  55                  60                  


Ile Ala Thr Gly Thr Val Ile Ile Leu Leu Gly Thr Phe Gly Cys Phe 
65                  70                  75                  80  


Ala Thr Cys Arg Ala Ser Ala Trp Met Leu Lys Leu Tyr Ala Met Phe 
                85                  90                  95      


Leu Thr Leu Val Phe Leu Val Glu Leu Val Ala Ala Ile Val Gly Phe 
            100                 105                 110         


Val Phe Arg His Glu Ile Lys Asn Ser Phe Lys Asn Asn Tyr Glu Lys 
        115                 120                 125             


Ala Leu Lys Gln Tyr Asn Ser Thr Gly Asp Tyr Arg Ser His Ala Val 
    130                 135                 140                 


Asp Lys Ile Gln Asn Thr Leu His Cys Cys Gly Val Thr Asp Tyr Arg 
145                 150                 155                 160 


Asp Trp Thr Asp Thr Asn Tyr Tyr Ser Glu Lys Gly Phe Pro Lys Ser 
                165                 170                 175     


Cys Cys Lys Leu Glu Asp Cys Thr Pro Gln Arg Asp Ala Asp Lys Val 
            180                 185                 190         


Asn Asn Glu Gly Cys Phe Ile Lys Val Met Thr Ile Ile Glu Ser Glu 
        195                 200                 205             


Met Gly Val Val Ala Gly Ile Ser Phe Gly Val Ala Cys Phe Gln Leu 
    210                 215                 220                 


Ile Gly Ile Phe Leu Ala Tyr Cys Leu Ser Arg Ala Ile Thr Asn Asn 
225                 230                 235                 240 


Gln Tyr Glu Ile Val 
                245 


<210>  4146
<211>  2133
<212>  DNA
<213>  Homosapiens

<400>  4146
ctgagttcct ctaatccctg tgttccttct cccccatctt tctaaaaccc ttctctgaga     60

gaggaataac tatagcttca gggataatat agctttaagg aaacttttgg cagatgtgga    120

cgtcgtaaca tctgggcagt gttaacagaa tcccggaggc cgggacagac caggagccac    180

tcgttctagg aatgttaaag tagaaggttt tttccaattg atgagaggag cagagaggaa    240

ggagaaagag gaggagagag aaaaagggca caaaatacca taaaacagat cccatatttc    300

tgcttcccct cacttttaga agttaattga tggctgactt ctgaaagtca ctttcctttg    360

ccctggtact tcaggccata tacatctttt cttgtctcca taatcctccc tttcaaggat    420

ggccagtcag ctaactcaaa gaggagctct ctttctgctg ttcttcctaa ctccggcagt    480

gacaccaaca tggtatgcag gttctggcta ctatccggat gaaagctaca atgaagtata    540

tgcagaggag gtcccacagg ctcctgccct ggactaccga gtcccccgat ggtgttatac    600

attaaatatc caggatggag aagccacatg ctactcaccg aagggaggaa attatcacag    660

cagcctgggc acgcgttgtg agctctcctg tgaccggggc tttcgattga ttggaaggag    720

gtcggtgcaa tgcctgccaa gccgtcgttg gtctggaact gcctactgca ggcagatgag    780

atgccacgca ctaccattca tcactagtgg cacttacacc tgcacaaatg gagtgcttct    840

tgactctcgc tgtgactaca gctgttccag tggctaccac ctggaaggtg atcgcagccg    900

aatctgcatg gaagatggga gatggagtgg aggcgagcct gtatgtgtag acatagatcc    960

ccccaagatc cgctgtcccc actcacgtga gaagatggca gagccagaga aattgactgc   1020

tcgagtatac tgggacccac cgttggtgaa agattctgct gatggtacca tcaccagggt   1080

gacacttcgg ggccctgagc ctggctctca ctttcccgaa ggagagcatg tgattcgtta   1140

cactgcctat gaccgagcct acaaccgggc cagctgcaag ttcattgtga aagtacaagt   1200

gagacgctgc ccaactctga aacctccgca gcacggctac ctcacctgca cctcagcggg   1260

ggacaactat ggtgccacct gtgaatacca ctgtgatggc ggttatgatc gccaggggac   1320

accctcccgg gtctgtcagt ccagccgcca gtggtcaggt tcaccaccaa tctgtgctcc   1380

tatgaagatt aacgtcaacg tcaactcagc tgctggtctc ttggatcaat tctatgagaa   1440

acagcgactc ctcatcatct cagctcctga tccttccaac cgatattata aaatgcagat   1500

ctctatgcta cagcaatcca cctgtggact ggatttgcgg catgtgacca tcattgaact   1560

ggtgggacag ccacctcagg aggtggggcg catccgggag caacagctgt cagccaacat   1620

catcgaggag ctcaggcaat ttcagcgcct cactcgctcc tacttcaaca tggtgttgat   1680

tgacaagcag ggtattgacc gagaccgcta catggaacct gtcacccccg aggaaatctt   1740

cacattcatt gatgactacc tactgagcaa tcaggagttg acccagcgtc gggagcaaag   1800

ggacatatgc gagtgaactt gagccagggc atggttaaag tcaagggaaa agctcctcta   1860

gttagctgaa actgggacct aataaaagga ggaaatgttt tcccacagtt ctagggacag   1920

gactctgagg tgggtgagtt tgacaaatcc tgcagtgttt ccaggcatcc ttttaggact   1980

gtgtaatagt ttccctagaa gctaggtagg gactgaggac aggccttggg cagtgggttg   2040

ggggtagaag ttcttccttt cctaacccgg gcccctgccc agctctccaa agtctttcag   2100

aaaagtaaat cctaaattca gtgaaaaaaa aac                                2133


<210>  4147
<211>  465
<212>  PRT
<213>  Homosapiens

<400>  4147

Met Ala Ser Gln Leu Thr Gln Arg Gly Ala Leu Phe Leu Leu Phe Phe 
1               5                   10                  15      


Leu Thr Pro Ala Val Thr Pro Thr Trp Tyr Ala Gly Ser Gly Tyr Tyr 
            20                  25                  30          


Pro Asp Glu Ser Tyr Asn Glu Val Tyr Ala Glu Glu Val Pro Gln Ala 
        35                  40                  45              


Pro Ala Leu Asp Tyr Arg Val Pro Arg Trp Cys Tyr Thr Leu Asn Ile 
    50                  55                  60                  


Gln Asp Gly Glu Ala Thr Cys Tyr Ser Pro Lys Gly Gly Asn Tyr His 
65                  70                  75                  80  


Ser Ser Leu Gly Thr Arg Cys Glu Leu Ser Cys Asp Arg Gly Phe Arg 
                85                  90                  95      


Leu Ile Gly Arg Arg Ser Val Gln Cys Leu Pro Ser Arg Arg Trp Ser 
            100                 105                 110         


Gly Thr Ala Tyr Cys Arg Gln Met Arg Cys His Ala Leu Pro Phe Ile 
        115                 120                 125             


Thr Ser Gly Thr Tyr Thr Cys Thr Asn Gly Val Leu Leu Asp Ser Arg 
    130                 135                 140                 


Cys Asp Tyr Ser Cys Ser Ser Gly Tyr His Leu Glu Gly Asp Arg Ser 
145                 150                 155                 160 


Arg Ile Cys Met Glu Asp Gly Arg Trp Ser Gly Gly Glu Pro Val Cys 
                165                 170                 175     


Val Asp Ile Asp Pro Pro Lys Ile Arg Cys Pro His Ser Arg Glu Lys 
            180                 185                 190         


Met Ala Glu Pro Glu Lys Leu Thr Ala Arg Val Tyr Trp Asp Pro Pro 
        195                 200                 205             


Leu Val Lys Asp Ser Ala Asp Gly Thr Ile Thr Arg Val Thr Leu Arg 
    210                 215                 220                 


Gly Pro Glu Pro Gly Ser His Phe Pro Glu Gly Glu His Val Ile Arg 
225                 230                 235                 240 


Tyr Thr Ala Tyr Asp Arg Ala Tyr Asn Arg Ala Ser Cys Lys Phe Ile 
                245                 250                 255     


Val Lys Val Gln Val Arg Arg Cys Pro Thr Leu Lys Pro Pro Gln His 
            260                 265                 270         


Gly Tyr Leu Thr Cys Thr Ser Ala Gly Asp Asn Tyr Gly Ala Thr Cys 
        275                 280                 285             


Glu Tyr His Cys Asp Gly Gly Tyr Asp Arg Gln Gly Thr Pro Ser Arg 
    290                 295                 300                 


Val Cys Gln Ser Ser Arg Gln Trp Ser Gly Ser Pro Pro Ile Cys Ala 
305                 310                 315                 320 


Pro Met Lys Ile Asn Val Asn Val Asn Ser Ala Ala Gly Leu Leu Asp 
                325                 330                 335     


Gln Phe Tyr Glu Lys Gln Arg Leu Leu Ile Ile Ser Ala Pro Asp Pro 
            340                 345                 350         


Ser Asn Arg Tyr Tyr Lys Met Gln Ile Ser Met Leu Gln Gln Ser Thr 
        355                 360                 365             


Cys Gly Leu Asp Leu Arg His Val Thr Ile Ile Glu Leu Val Gly Gln 
    370                 375                 380                 


Pro Pro Gln Glu Val Gly Arg Ile Arg Glu Gln Gln Leu Ser Ala Asn 
385                 390                 395                 400 


Ile Ile Glu Glu Leu Arg Gln Phe Gln Arg Leu Thr Arg Ser Tyr Phe 
                405                 410                 415     


Asn Met Val Leu Ile Asp Lys Gln Gly Ile Asp Arg Asp Arg Tyr Met 
            420                 425                 430         


Glu Pro Val Thr Pro Glu Glu Ile Phe Thr Phe Ile Asp Asp Tyr Leu 
        435                 440                 445             


Leu Ser Asn Gln Glu Leu Thr Gln Arg Arg Glu Gln Arg Asp Ile Cys 
    450                 455                 460                 


Glu 
465 


<210>  4148
<211>  3914
<212>  DNA
<213>  Homosapiens

<400>  4148
cacagcgctc ggccgtcgag cggggtcgct aacccgcact ctcttcggac ctacgacatc     60

gcggcttctc tggcgttggc cagtcagcca cagggaacta gtaaaaaaag aaaaagaaaa    120

aataaagtga aagaggcgtg ttgtctagtt tcaaaggaga ggagagaaga gactgagtcg    180

ccctgtgttg cccaggctgg tcttgaactc ctaggctcaa gagatcctcc tgcctcagcc    240

tcccaaagtg ctgggattac aggcaactct ggtagctctc cttgtctggt tgttttgaag    300

aaagaagagt agaagaaaaa gttgagtaaa tcatgtcgga gttactggac ctttcttttc    360

tgtctgagga ggaaaaggat ttgattctca gtgttctaca gcgagatgaa gaggtccgga    420

aagcagatga gaaaaggatt aggcgactaa agaatgagtt actggagata aaaaggaaag    480

gggccaagag gggcagccaa cactacagtg atcggacctg tgcccggtgc caggagagcc    540

tgggccgttt gagtcccaaa accaatactt gtcggggttg taatcacctg gtgtgtcggg    600

actgccgcat acaggaaagc aatggtacct ggaggtgcaa ggtgtgcgcc aaggaaatag    660

agttgaagaa agcaactggg gactggtttt atgaccagaa agtgaatcgc tttgcttacc    720

gcacaggtag tgagataatc aggatgtccc tgcgccacaa acctgcagtg agtaaaagag    780

agacagtggg acagtccctc cttcatcaga cacagatggg tgacatctgg ccaggaagaa    840

agatcattca ggagcggcag aaggagccca gtgtgctatt tgaagtgcca aagctgaaaa    900

gtggaaagag tgcattggaa gctgagagtg agagtctgga tagcttcaca gctgactcgg    960

atagcacctc caggagagac tctctggata aatctggcct ctttccagaa tggaagaaga   1020

tgtctgctcc caaatctcaa gtagaaaagg aaactcagcc tggaggtcaa aatgtggtat   1080

ttgtggatga gggtgagatg atatttaaga agaacaccag aaaaatcctc aggccttcag   1140

agtacactaa atctgtgata gatcttcgcc cagaagatgt ggtacatgaa agtggctcct   1200

tgggagacag aagcaaatcc gtcccaggcc tcaatgtgga tatggaagag gaagaagaag   1260

aagaagacat tgaccaccta gtgaagttac atcgccagaa gctagccaga agcagcatgc   1320

aaagtggctc ctccatgagt acgatcggca gcatgatgag catctacagt gaagctggtg   1380

atttcgggaa catctttgtg actggcagga ttgccttttc cctgaagtat gagcagcaaa   1440

cccagagtct ggttgtccat gtgaaggagt gccatcagct ggcctatgct gatgaagcca   1500

agaagcgctc taacccatat gtgaagactt accttctgcc tgacaagtcc cgccaaggaa   1560

aaagaaaaac cagcatcaag cgggacactg ttaatccact atatgatgag acgctgaggt   1620

atgagatccc agaatctctc ctggcccaga ggaccctgca gttctcagtt tggcatcatg   1680

gtcgttttgg cagaaacact ttccttggag aggcagagat ccagatggat tcctggaagc   1740

ttgataagaa actggatcat tgcctccctt tacatggaaa gatcagtgct gagtccccga   1800

ctggcttgcc atcacacaaa ggcgagttgg tggtttcatt gaaatacatc ccagcctcca   1860

aaacccctgt tggaggtgac cggaaaaaga gtaaaggtgg ggaaggggga gagctccagg   1920

tgtggatcaa agaagccaag aacttgacgg ctgccaaagc aggagggact tcagacagct   1980

ttgtcaaggg atacctcctt cccatgagga acaaggccag taaacgtaaa actcctgtga   2040

tgaagaagac cctgaatcct cactacaacc atacatttgt ctacaatggt gtgaggctgg   2100

aagatctaca gcatatgtgc ctggaactga ctgtgtggga ccgggagccc ctggccagca   2160

atgacttcct gggaggggtc aggctgggtg ttggcactgg gatcagtaat ggggaagtgg   2220

tggactggat ggactcgact ggggaagaag tgagcctgtg gcagaagatg cgacagtacc   2280

cagggtcttg ggcagaaggg actctgcagc tccgttcctc aatggccaag cagaagctgg   2340

gtttatgagt ccctgtcctc ttctgcaggt ccagccctgg cgagggcagg tcagaggaag   2400

tgaagaaatc aagagcaaag atttataatt taatgtgtat gtgtgtatgt gtgtatgtgt   2460

gtgtgtgtgt gtgtgtgtgt gtgtgtgtac aaacatgtat tttctgcaaa tctcattatg   2520

ctggctagag tgatgcagac ttgttcttct ttttaaagca gtctcaagaa taagcatttc   2580

tttaaaatgt ttctgtgtat aatctagttt attttcagag tccatttttt cttatgtctt   2640

tataaggttc acttaactta aaaacagctt ttaaaacaac tttttatctt ctgtcttgct   2700

atcattgttc ctacttccct aggaagccct ggctaccttt cgcattagga ccagtctggg   2760

ttttaaggct ctgggaagca gggttggtta gtaaagacag gaatgttggg gagaggtgag   2820

tagttccttc ctctttctcc tctccaattt atgcttttaa cttattttct acctggataa   2880

acttctggaa cttggctttt aaatttaact tttctagttt ttaagcagtt tccaccttgc   2940

tttggtctaa tgcttttctt tgaaatgcta acagaattcc caagcttttt ccagttctag   3000

atatctttac tagacctttg ggggactctt ataatggagc tgcttttgaa aagcacttta   3060

attagataat gtattttgac taaatcacga ggatgcccag tgagagcttc tagctgatct   3120

cagaggacca gagtgactga gggtaaagtg tctcacagcc catgctgaat tttctgcatt   3180

ttaaactgat actgcagtca ttggagagag agctcctcat ttctcgaatg aaagatgaga   3240

tatattcatc ctcatgtacc acatctgtct tagtgtttgc gtctggggtg tgttatcaaa   3300

cagagcatgg tctacatccc actgtgtcaa ccagaagagc caagtgttat ctcaattggc   3360

ccagtgtttc tccaggctgg ggactgttaa gggctctaag ggaatgtaga cagagtctcc   3420

ctgttattct gacttcctgc ttgatgagct ttcagttcct gtttttgcta ttgtttccta   3480

aatttgacct acatattaca tgggtgtagt gtgttgaggc ttttcaaaga agggtctagt   3540

gagctaagtt tcatcttctg gtactcattg atcaaactga cctttctatt ctcataagcg   3600

tttctaccca aagttgtgtg tggaaggagt gtatagcaga gaggaaatcc ctttcaacag   3660

agtcagctgc taactgattt cctataagca cactggatta agggcagcca cagtggtttc   3720

tactgtatgt atgaaccgaa tggaggaatg ttttcaaaga ttgatttggt gtggattgca   3780

attgtaatgg aaggcataac ttgggatccc gggctgtaac ttgctctttt gtttcccacc   3840

cccctgacat gtatgtgtgc tttaataaag ctttctcact tgtcaaaaaa aaaaaaaaaa   3900

aaaaaaaaaa aaaa                                                     3914


<210>  4149
<211>  671
<212>  PRT
<213>  Homosapiens

<400>  4149

Met Ser Glu Leu Leu Asp Leu Ser Phe Leu Ser Glu Glu Glu Lys Asp 
1               5                   10                  15      


Leu Ile Leu Ser Val Leu Gln Arg Asp Glu Glu Val Arg Lys Ala Asp 
            20                  25                  30          


Glu Lys Arg Ile Arg Arg Leu Lys Asn Glu Leu Leu Glu Ile Lys Arg 
        35                  40                  45              


Lys Gly Ala Lys Arg Gly Ser Gln His Tyr Ser Asp Arg Thr Cys Ala 
    50                  55                  60                  


Arg Cys Gln Glu Ser Leu Gly Arg Leu Ser Pro Lys Thr Asn Thr Cys 
65                  70                  75                  80  


Arg Gly Cys Asn His Leu Val Cys Arg Asp Cys Arg Ile Gln Glu Ser 
                85                  90                  95      


Asn Gly Thr Trp Arg Cys Lys Val Cys Ala Lys Glu Ile Glu Leu Lys 
            100                 105                 110         


Lys Ala Thr Gly Asp Trp Phe Tyr Asp Gln Lys Val Asn Arg Phe Ala 
        115                 120                 125             


Tyr Arg Thr Gly Ser Glu Ile Ile Arg Met Ser Leu Arg His Lys Pro 
    130                 135                 140                 


Ala Val Ser Lys Arg Glu Thr Val Gly Gln Ser Leu Leu His Gln Thr 
145                 150                 155                 160 


Gln Met Gly Asp Ile Trp Pro Gly Arg Lys Ile Ile Gln Glu Arg Gln 
                165                 170                 175     


Lys Glu Pro Ser Val Leu Phe Glu Val Pro Lys Leu Lys Ser Gly Lys 
            180                 185                 190         


Ser Ala Leu Glu Ala Glu Ser Glu Ser Leu Asp Ser Phe Thr Ala Asp 
        195                 200                 205             


Ser Asp Ser Thr Ser Arg Arg Asp Ser Leu Asp Lys Ser Gly Leu Phe 
    210                 215                 220                 


Pro Glu Trp Lys Lys Met Ser Ala Pro Lys Ser Gln Val Glu Lys Glu 
225                 230                 235                 240 


Thr Gln Pro Gly Gly Gln Asn Val Val Phe Val Asp Glu Gly Glu Met 
                245                 250                 255     


Ile Phe Lys Lys Asn Thr Arg Lys Ile Leu Arg Pro Ser Glu Tyr Thr 
            260                 265                 270         


Lys Ser Val Ile Asp Leu Arg Pro Glu Asp Val Val His Glu Ser Gly 
        275                 280                 285             


Ser Leu Gly Asp Arg Ser Lys Ser Val Pro Gly Leu Asn Val Asp Met 
    290                 295                 300                 


Glu Glu Glu Glu Glu Glu Glu Asp Ile Asp His Leu Val Lys Leu His 
305                 310                 315                 320 


Arg Gln Lys Leu Ala Arg Ser Ser Met Gln Ser Gly Ser Ser Met Ser 
                325                 330                 335     


Thr Ile Gly Ser Met Met Ser Ile Tyr Ser Glu Ala Gly Asp Phe Gly 
            340                 345                 350         


Asn Ile Phe Val Thr Gly Arg Ile Ala Phe Ser Leu Lys Tyr Glu Gln 
        355                 360                 365             


Gln Thr Gln Ser Leu Val Val His Val Lys Glu Cys His Gln Leu Ala 
    370                 375                 380                 


Tyr Ala Asp Glu Ala Lys Lys Arg Ser Asn Pro Tyr Val Lys Thr Tyr 
385                 390                 395                 400 


Leu Leu Pro Asp Lys Ser Arg Gln Gly Lys Arg Lys Thr Ser Ile Lys 
                405                 410                 415     


Arg Asp Thr Val Asn Pro Leu Tyr Asp Glu Thr Leu Arg Tyr Glu Ile 
            420                 425                 430         


Pro Glu Ser Leu Leu Ala Gln Arg Thr Leu Gln Phe Ser Val Trp His 
        435                 440                 445             


His Gly Arg Phe Gly Arg Asn Thr Phe Leu Gly Glu Ala Glu Ile Gln 
    450                 455                 460                 


Met Asp Ser Trp Lys Leu Asp Lys Lys Leu Asp His Cys Leu Pro Leu 
465                 470                 475                 480 


His Gly Lys Ile Ser Ala Glu Ser Pro Thr Gly Leu Pro Ser His Lys 
                485                 490                 495     


Gly Glu Leu Val Val Ser Leu Lys Tyr Ile Pro Ala Ser Lys Thr Pro 
            500                 505                 510         


Val Gly Gly Asp Arg Lys Lys Ser Lys Gly Gly Glu Gly Gly Glu Leu 
        515                 520                 525             


Gln Val Trp Ile Lys Glu Ala Lys Asn Leu Thr Ala Ala Lys Ala Gly 
    530                 535                 540                 


Gly Thr Ser Asp Ser Phe Val Lys Gly Tyr Leu Leu Pro Met Arg Asn 
545                 550                 555                 560 


Lys Ala Ser Lys Arg Lys Thr Pro Val Met Lys Lys Thr Leu Asn Pro 
                565                 570                 575     


His Tyr Asn His Thr Phe Val Tyr Asn Gly Val Arg Leu Glu Asp Leu 
            580                 585                 590         


Gln His Met Cys Leu Glu Leu Thr Val Trp Asp Arg Glu Pro Leu Ala 
        595                 600                 605             


Ser Asn Asp Phe Leu Gly Gly Val Arg Leu Gly Val Gly Thr Gly Ile 
    610                 615                 620                 


Ser Asn Gly Glu Val Val Asp Trp Met Asp Ser Thr Gly Glu Glu Val 
625                 630                 635                 640 


Ser Leu Trp Gln Lys Met Arg Gln Tyr Pro Gly Ser Trp Ala Glu Gly 
                645                 650                 655     


Thr Leu Gln Leu Arg Ser Ser Met Ala Lys Gln Lys Leu Gly Leu 
            660                 665                 670     


<210>  4150
<211>  1354
<212>  DNA
<213>  Homosapiens

<400>  4150
ccaaacatgg atcctcatga ttttattttc tagattggct gataggctga ataatctcct     60

gtagggtaag aagtgtcaac tgtatcaagc acatggaggt ggactggcta caggagaaag    120

tgtgacgtgg gtgaaggagt tcttattgag ccatgggagg aagaaatagt acagaagagc    180

aaagaataat aatgagtcag ctagacagaa gacaggagtc atcagatttg taccctagtt    240

actcgaccca tcaactgact gtggtttttg ggaacaggcc cggcaccacc tctgcgcaca    300

accccgcggg cctggctcag gcgggagtgc ggggccagca ccatgagcgc cccgggcagc    360

cccgaccagg cctatgactt cctgctcaag ttcctgctgg tgggcgacag ggacgtaggc    420

aagagtgaga tcctggagag cctgcaggat ggtgcagctg agtccccgta cagccatctc    480

ggggggatcg actacaagac gaccaccatc ctgctggacg gccagcgggt gaagctgaag    540

ctctgggata cgtcggggca gggaagattt tgtaccatat tccgctccta ctctcgtggt    600

gcacaaggag tgatcctggt ctacgacatt gcaaaccgct ggtctttcga gggtatggat    660

cgatggatta agaagattga ggaacatgcc cctggtgtcc ctaaaatcct ggtggggaat    720

cgcctacatc tggcattcaa gaggcaggtg cccagggagc aggcccaggc ctacgccgag    780

cgcctgggtg tgaccttctt tgaggtcagc cctctgtgca atttcaacat catagagtct    840

ttcacggagc tggccaggat agtgctgctg cggcacagga tgaattggct cgggaggccg    900

agcaaggtac tgagcttgca agacctctgc tgccgcacca tcgtgtcctg cacacctgtg    960

catctggtgg acaagctccc gctccccagt accttaagaa gccacctcaa gtccttctcc   1020

atggctaagg gcctgaatgc caggatgatg cgaggcctct cctactccct caccaccagc   1080

tccactcaca agagcagcct ctgcaaagtg gagatcgtct gcccacccca gagcccaccc   1140

aaaaactgca ccagaaacag ctgcaaaatt tcttaaggaa ggcaccaaaa ggaaacaagc   1200

tggaatcgct ccaggaaaaa ctctggttac acctggaaga tggaagtcgc attgtagatt   1260

caagaaatta gttttcagtt tctcacggga accatgctgc ttgggaatgt gtgtgatgcc   1320

ttctgtcaat aaaaacacat tacacaaaaa aaaa                               1354


<210>  4151
<211>  277
<212>  PRT
<213>  Homosapiens

<400>  4151

Met Ser Ala Pro Gly Ser Pro Asp Gln Ala Tyr Asp Phe Leu Leu Lys 
1               5                   10                  15      


Phe Leu Leu Val Gly Asp Arg Asp Val Gly Lys Ser Glu Ile Leu Glu 
            20                  25                  30          


Ser Leu Gln Asp Gly Ala Ala Glu Ser Pro Tyr Ser His Leu Gly Gly 
        35                  40                  45              


Ile Asp Tyr Lys Thr Thr Thr Ile Leu Leu Asp Gly Gln Arg Val Lys 
    50                  55                  60                  


Leu Lys Leu Trp Asp Thr Ser Gly Gln Gly Arg Phe Cys Thr Ile Phe 
65                  70                  75                  80  


Arg Ser Tyr Ser Arg Gly Ala Gln Gly Val Ile Leu Val Tyr Asp Ile 
                85                  90                  95      


Ala Asn Arg Trp Ser Phe Glu Gly Met Asp Arg Trp Ile Lys Lys Ile 
            100                 105                 110         


Glu Glu His Ala Pro Gly Val Pro Lys Ile Leu Val Gly Asn Arg Leu 
        115                 120                 125             


His Leu Ala Phe Lys Arg Gln Val Pro Arg Glu Gln Ala Gln Ala Tyr 
    130                 135                 140                 


Ala Glu Arg Leu Gly Val Thr Phe Phe Glu Val Ser Pro Leu Cys Asn 
145                 150                 155                 160 


Phe Asn Ile Ile Glu Ser Phe Thr Glu Leu Ala Arg Ile Val Leu Leu 
                165                 170                 175     


Arg His Arg Met Asn Trp Leu Gly Arg Pro Ser Lys Val Leu Ser Leu 
            180                 185                 190         


Gln Asp Leu Cys Cys Arg Thr Ile Val Ser Cys Thr Pro Val His Leu 
        195                 200                 205             


Val Asp Lys Leu Pro Leu Pro Ser Thr Leu Arg Ser His Leu Lys Ser 
    210                 215                 220                 


Phe Ser Met Ala Lys Gly Leu Asn Ala Arg Met Met Arg Gly Leu Ser 
225                 230                 235                 240 


Tyr Ser Leu Thr Thr Ser Ser Thr His Lys Ser Ser Leu Cys Lys Val 
                245                 250                 255     


Glu Ile Val Cys Pro Pro Gln Ser Pro Pro Lys Asn Cys Thr Arg Asn 
            260                 265                 270         


Ser Cys Lys Ile Ser 
        275         


<210>  4152
<211>  1294
<212>  DNA
<213>  Homosapiens

<400>  4152
tgggctgcgg cattcacgtg atctgcacgg gcgcagatgt aggcaccggt ccgagtgcct     60

gccctctgtc cccgcggctg ggtctcgtct gctccggttc ctgggctcct aattcttggt    120

ccagcttctt ccaggtctgc gcgtctgttg ttcccagcgc tctgcgaagc ctgaaaagga    180

ggagcaacct gtccagaatc cccgcaggac aggaaaagga ggggaaatct cgacatggaa    240

aaactctaca gtgaaaatga aggaatggct tcaaaccaag gaaagatgga aaatgaagaa    300

cagccacaag acgagagaaa gccagaagta acttgtactc tggaagacaa gaagttagaa    360

aacgagggaa agacagaaaa caagggcaaa acaggagatg aggaaatgtt aaaggataaa    420

ggaaagccag agagtgaggg agaggcaaaa gaaggaaagt cagagaggga gggagagtca    480

gagatggagg gaggatcaga gagagaggga aaaccagaga tagagggaaa gccagagagt    540

gaaggagagc cagggagtga aacaagggct gcaggaaagc gcccagctga ggatgatgta    600

cccaggaaag ccaaaagaaa aactaataag gggctggctc attacctcaa ggagtataaa    660

gaggccatac atgatatgaa tttcagcaat gaggacatga taagagaatt tgacaatatg    720

gctaaggtgc aggatgagaa gagaaaaagc aaacagaaat tgggggcgtt tttgtggatg    780

caaagaaatt tacaggaccc cttctaccct agaggtccaa gggaattcag gggtggctgc    840

agggccccac gaagggacat tgaagacatt ccttatgtgt agtgtccctg gcaggcattt    900

accaggccat gtgctttaac gttacggtaa tactttactt taggcatccc tcctgttgct    960

agcagccttt tgacctatct gcaatgcagt gttctcagta ggaaatgttc atctgttaca   1020

tggaaaaaat gttgatggtg cattgtaaaa ttaaaaaaca caacttgcag aaccaaatat   1080

atggcatcag tacatttttg taaaactaca aagatactta cctagtaata tagtatagaa   1140

aacaattctg aaagctgtgt ccactaaaag attaacagtg gttatctctg ggtgattttt   1200

tctgttcttt tttgttcatc tgtccatttt tctcctaaaa acagatttct ttagtcataa   1260

aaataataaa atataaagta ttggaaaaaa aaaa                               1294


<210>  4153
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  4153

Met Glu Lys Leu Tyr Ser Glu Asn Glu Gly Met Ala Ser Asn Gln Gly 
1               5                   10                  15      


Lys Met Glu Asn Glu Glu Gln Pro Gln Asp Glu Arg Lys Pro Glu Val 
            20                  25                  30          


Thr Cys Thr Leu Glu Asp Lys Lys Leu Glu Asn Glu Gly Lys Thr Glu 
        35                  40                  45              


Asn Lys Gly Lys Thr Gly Asp Glu Glu Met Leu Lys Asp Lys Gly Lys 
    50                  55                  60                  


Pro Glu Ser Glu Gly Glu Ala Lys Glu Gly Lys Ser Glu Arg Glu Gly 
65                  70                  75                  80  


Glu Ser Glu Met Glu Gly Gly Ser Glu Arg Glu Gly Lys Pro Glu Ile 
                85                  90                  95      


Glu Gly Lys Pro Glu Ser Glu Gly Glu Pro Gly Ser Glu Thr Arg Ala 
            100                 105                 110         


Ala Gly Lys Arg Pro Ala Glu Asp Asp Val Pro Arg Lys Ala Lys Arg 
        115                 120                 125             


Lys Thr Asn Lys Gly Leu Ala His Tyr Leu Lys Glu Tyr Lys Glu Ala 
    130                 135                 140                 


Ile His Asp Met Asn Phe Ser Asn Glu Asp Met Ile Arg Glu Phe Asp 
145                 150                 155                 160 


Asn Met Ala Lys Val Gln Asp Glu Lys Arg Lys Ser Lys Gln Lys Leu 
                165                 170                 175     


Gly Ala Phe Leu Trp Met Gln Arg Asn Leu Gln Asp Pro Phe Tyr Pro 
            180                 185                 190         


Arg Gly Pro Arg Glu Phe Arg Gly Gly Cys Arg Ala Pro Arg Arg Asp 
        195                 200                 205             


Ile Glu Asp Ile Pro Tyr Val 
    210                 215 


<210>  4154
<211>  1293
<212>  DNA
<213>  Homosapiens

<400>  4154
tgggctgcgg cattcacgtg atctgcacgg gcgcagatgt aggcaccggt ccgagtgcct     60

gccctctgtc cccgcggctg ggtctcgtct gctccggttc ctgggctcct aattcttggt    120

ccagcttctt ccaggtctgc gcgtctgttg ttcccagcgc tctgcgaagc ctgaaaagga    180

ggagcaacct gtccagaatc cccgcagaca ggaaaaggag gggaaatctc gacatggaaa    240

aactctacag tgaaaatgaa ggaatggctt caaaccaagg aaagatggaa aatgaagaac    300

agccacaaga cgagagaaag ccagaagtaa cttgtactct ggaagacaag aagttagaaa    360

acgagggaaa gacagaaaac aagggcaaaa caggagatga ggaaatgtta aaggataaag    420

gaaagccaga gagtgaggga gaggcaaaag aaggaaagtc agagagggag ggagagtcag    480

agatggaggg aggatcagag agagagggaa aaccagagat agagggaaag ccagagagtg    540

aaggagagcc agggagtgaa acaagggctg caggaaagcg cccagctgag gatgatgtac    600

ccaggaaagc caaaagaaaa actaataagg ggctggctca ttacctcaag gagtataaag    660

aggccataca tgatatgaat ttcagcaatg aggacatgat aagagaattt gacaatatgg    720

ctaaggtgca ggatgagaag agaaaaagca aacagaaatt gggggcgttt ttgtggatgc    780

aaagaaattt acaggacccc ttctacccta gaggtccaag ggaattcagg ggtggctgca    840

gggccccacg aagggacatt gaagacattc cttatgtgta gtgtccctgg caggcattta    900

ccaggccatg tgctttaacg ttacggtaat actttacttt aggcatccct cctgttgcta    960

gcagcctttt gacctatctg caatgcagtg ttctcagtag gaaatgttca tctgttacat   1020

ggaaaaaatg ttgatggtgc attgtaaaat taaaaaacac aacttgcaga accaaatata   1080

tggcatcagt acatttttgt aaaactacaa agatacttac ctagtaatat agtatagaaa   1140

acaattctga aagctgtgtc cactaaaaga ttaacagtgg ttatctctgg gtgatttttt   1200

ctgttctttt ttgttcatct gtccattttt ctcctaaaaa cagatttctt tagtcataaa   1260

aataataaaa tataaagtat tggaaaaaaa aaa                                1293


<210>  4155
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  4155

Met Glu Lys Leu Tyr Ser Glu Asn Glu Gly Met Ala Ser Asn Gln Gly 
1               5                   10                  15      


Lys Met Glu Asn Glu Glu Gln Pro Gln Asp Glu Arg Lys Pro Glu Val 
            20                  25                  30          


Thr Cys Thr Leu Glu Asp Lys Lys Leu Glu Asn Glu Gly Lys Thr Glu 
        35                  40                  45              


Asn Lys Gly Lys Thr Gly Asp Glu Glu Met Leu Lys Asp Lys Gly Lys 
    50                  55                  60                  


Pro Glu Ser Glu Gly Glu Ala Lys Glu Gly Lys Ser Glu Arg Glu Gly 
65                  70                  75                  80  


Glu Ser Glu Met Glu Gly Gly Ser Glu Arg Glu Gly Lys Pro Glu Ile 
                85                  90                  95      


Glu Gly Lys Pro Glu Ser Glu Gly Glu Pro Gly Ser Glu Thr Arg Ala 
            100                 105                 110         


Ala Gly Lys Arg Pro Ala Glu Asp Asp Val Pro Arg Lys Ala Lys Arg 
        115                 120                 125             


Lys Thr Asn Lys Gly Leu Ala His Tyr Leu Lys Glu Tyr Lys Glu Ala 
    130                 135                 140                 


Ile His Asp Met Asn Phe Ser Asn Glu Asp Met Ile Arg Glu Phe Asp 
145                 150                 155                 160 


Asn Met Ala Lys Val Gln Asp Glu Lys Arg Lys Ser Lys Gln Lys Leu 
                165                 170                 175     


Gly Ala Phe Leu Trp Met Gln Arg Asn Leu Gln Asp Pro Phe Tyr Pro 
            180                 185                 190         


Arg Gly Pro Arg Glu Phe Arg Gly Gly Cys Arg Ala Pro Arg Arg Asp 
        195                 200                 205             


Ile Glu Asp Ile Pro Tyr Val 
    210                 215 


<210>  4156
<211>  1289
<212>  DNA
<213>  Homosapiens

<400>  4156
tgggctgcgg cattcacgtg atctgcacgg gcgcagatgt aggcaccggt ccgagtgcct     60

gccctctgtc cccgcggctg ggtctcgtct gctccggttc ctgggctcct aattcttggt    120

ccagcttctt ccaggtctgc gcgtctgttg ttcccagcgc tctgcgaagc ctgaaaagga    180

ggagcaacct gtccagaatc cccgcaggaa aaggagggga aatctcgaca tggaaaaact    240

ctacagtgaa aatgaaggaa tggcttcaaa ccaaggaaag atggaaaatg aagaacagcc    300

acaagacgag agaaagccag aagtaacttg tactctggaa gacaagaagt tagaaaacga    360

gggaaagaca gaaaacaagg gcaaaacagg agatgaggaa atgttaaagg ataaaggaaa    420

gccagagagt gagggagagg caaaagaagg aaagtcagag agggagggag agtcagagat    480

ggagggagga tcagagagag agggaaaacc agagatagag ggaaagccag agagtgaagg    540

agagccaggg agtgaaacaa gggctgcagg aaagcgccca gctgaggatg atgtacccag    600

gaaagccaaa agaaaaacta ataaggggct ggctcattac ctcaaggagt ataaagaggc    660

catacatgat atgaatttca gcaatgagga catgataaga gaatttgaca atatggctaa    720

ggtgcaggat gagaagagaa aaagcaaaca gaaattgggg gcgtttttgt ggatgcaaag    780

aaatttacag gaccccttct accctagagg tccaagggaa ttcaggggtg gctgcagggc    840

cccacgaagg gacattgaag acattcctta tgtgtagtgt ccctggcagg catttaccag    900

gccatgtgct ttaacgttac ggtaatactt tactttaggc atccctcctg ttgctagcag    960

ccttttgacc tatctgcaat gcagtgttct cagtaggaaa tgttcatctg ttacatggaa   1020

aaaatgttga tggtgcattg taaaattaaa aaacacaact tgcagaacca aatatatggc   1080

atcagtacat ttttgtaaaa ctacaaagat acttacctag taatatagta tagaaaacaa   1140

ttctgaaagc tgtgtccact aaaagattaa cagtggttat ctctgggtga ttttttctgt   1200

tcttttttgt tcatctgtcc atttttctcc taaaaacaga tttctttagt cataaaaata   1260

ataaaatata aagtattgga aaaaaaaaa                                     1289


<210>  4157
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  4157

Met Glu Lys Leu Tyr Ser Glu Asn Glu Gly Met Ala Ser Asn Gln Gly 
1               5                   10                  15      


Lys Met Glu Asn Glu Glu Gln Pro Gln Asp Glu Arg Lys Pro Glu Val 
            20                  25                  30          


Thr Cys Thr Leu Glu Asp Lys Lys Leu Glu Asn Glu Gly Lys Thr Glu 
        35                  40                  45              


Asn Lys Gly Lys Thr Gly Asp Glu Glu Met Leu Lys Asp Lys Gly Lys 
    50                  55                  60                  


Pro Glu Ser Glu Gly Glu Ala Lys Glu Gly Lys Ser Glu Arg Glu Gly 
65                  70                  75                  80  


Glu Ser Glu Met Glu Gly Gly Ser Glu Arg Glu Gly Lys Pro Glu Ile 
                85                  90                  95      


Glu Gly Lys Pro Glu Ser Glu Gly Glu Pro Gly Ser Glu Thr Arg Ala 
            100                 105                 110         


Ala Gly Lys Arg Pro Ala Glu Asp Asp Val Pro Arg Lys Ala Lys Arg 
        115                 120                 125             


Lys Thr Asn Lys Gly Leu Ala His Tyr Leu Lys Glu Tyr Lys Glu Ala 
    130                 135                 140                 


Ile His Asp Met Asn Phe Ser Asn Glu Asp Met Ile Arg Glu Phe Asp 
145                 150                 155                 160 


Asn Met Ala Lys Val Gln Asp Glu Lys Arg Lys Ser Lys Gln Lys Leu 
                165                 170                 175     


Gly Ala Phe Leu Trp Met Gln Arg Asn Leu Gln Asp Pro Phe Tyr Pro 
            180                 185                 190         


Arg Gly Pro Arg Glu Phe Arg Gly Gly Cys Arg Ala Pro Arg Arg Asp 
        195                 200                 205             


Ile Glu Asp Ile Pro Tyr Val 
    210                 215 


<210>  4158
<211>  1353
<212>  DNA
<213>  Homosapiens

<400>  4158
tgggctgcgg cattcacgtg atctgcacgg gcgcagatgt aggcaccggt ccgagtgcct     60

gccctctgtc cccgcggctg ggtctcgtct gctccggttc ctgggctcct aattcttggt    120

ccagcttctt ccaggtcagt gtgcgggcct tccacgctgc cagcggaaca ctggaatggc    180

ggaaggggaa cgggtctgcg cgtctgttgt tcccagcgct ctgcgaagcc tgaaaaggag    240

gagcaacctg tccagaatcc ccgcaggaca ggaaaaggag gggaaatctc gacatggaaa    300

aactctacag tgaaaatgaa ggaatggctt caaaccaagg aaagatggaa aatgaagaac    360

agccacaaga cgagagaaag ccagaagtaa cttgtactct ggaagacaag aagttagaaa    420

acgagggaaa gacagaaaac aagggcaaaa caggagatga ggaaatgtta aaggataaag    480

gaaagccaga gagtgaggga gaggcaaaag aaggaaagtc agagagggag ggagagtcag    540

agatggaggg aggatcagag agagagggaa aaccagagat agagggaaag ccagagagtg    600

aaggagagcc agggagtgaa acaagggctg caggaaagcg cccagctgag gatgatgtac    660

ccaggaaagc caaaagaaaa actaataagg ggctggctca ttacctcaag gagtataaag    720

aggccataca tgatatgaat ttcagcaatg aggacatgat aagagaattt gacaatatgg    780

ctaaggtgca ggatgagaag agaaaaagca aacagaaatt gggggcgttt ttgtggatgc    840

aaagaaattt acaggacccc ttctacccta gaggtccaag ggaattcagg ggtggctgca    900

gggccccacg aagggacatt gaagacattc cttatgtgta gtgtccctgg caggcattta    960

ccaggccatg tgctttaacg ttacggtaat actttacttt aggcatccct cctgttgcta   1020

gcagcctttt gacctatctg caatgcagtg ttctcagtag gaaatgttca tctgttacat   1080

ggaaaaaatg ttgatggtgc attgtaaaat taaaaaacac aacttgcaga accaaatata   1140

tggcatcagt acatttttgt aaaactacaa agatacttac ctagtaatat agtatagaaa   1200

acaattctga aagctgtgtc cactaaaaga ttaacagtgg ttatctctgg gtgatttttt   1260

ctgttctttt ttgttcatct gtccattttt ctcctaaaaa cagatttctt tagtcataaa   1320

aataataaaa tataaagtat tggaaaaaaa aaa                                1353


<210>  4159
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  4159

Met Glu Lys Leu Tyr Ser Glu Asn Glu Gly Met Ala Ser Asn Gln Gly 
1               5                   10                  15      


Lys Met Glu Asn Glu Glu Gln Pro Gln Asp Glu Arg Lys Pro Glu Val 
            20                  25                  30          


Thr Cys Thr Leu Glu Asp Lys Lys Leu Glu Asn Glu Gly Lys Thr Glu 
        35                  40                  45              


Asn Lys Gly Lys Thr Gly Asp Glu Glu Met Leu Lys Asp Lys Gly Lys 
    50                  55                  60                  


Pro Glu Ser Glu Gly Glu Ala Lys Glu Gly Lys Ser Glu Arg Glu Gly 
65                  70                  75                  80  


Glu Ser Glu Met Glu Gly Gly Ser Glu Arg Glu Gly Lys Pro Glu Ile 
                85                  90                  95      


Glu Gly Lys Pro Glu Ser Glu Gly Glu Pro Gly Ser Glu Thr Arg Ala 
            100                 105                 110         


Ala Gly Lys Arg Pro Ala Glu Asp Asp Val Pro Arg Lys Ala Lys Arg 
        115                 120                 125             


Lys Thr Asn Lys Gly Leu Ala His Tyr Leu Lys Glu Tyr Lys Glu Ala 
    130                 135                 140                 


Ile His Asp Met Asn Phe Ser Asn Glu Asp Met Ile Arg Glu Phe Asp 
145                 150                 155                 160 


Asn Met Ala Lys Val Gln Asp Glu Lys Arg Lys Ser Lys Gln Lys Leu 
                165                 170                 175     


Gly Ala Phe Leu Trp Met Gln Arg Asn Leu Gln Asp Pro Phe Tyr Pro 
            180                 185                 190         


Arg Gly Pro Arg Glu Phe Arg Gly Gly Cys Arg Ala Pro Arg Arg Asp 
        195                 200                 205             


Ile Glu Asp Ile Pro Tyr Val 
    210                 215 


<210>  4160
<211>  1154
<212>  DNA
<213>  Homosapiens

<400>  4160
gtgggcacca gcccccgcgc ccgcccgccc gccctgcggt ccggtcctgg cgcccgcgca     60

gaaccagctg tctgagctgc ccgggcagcg ggggagcagc gagcgggctt ccgcgagccg    120

gagaaggcac aggcctgtcc cgggtcccgg caggtcagtg tgaaggtctg cgcgtctgtt    180

cccagcgctc tgcgaggcct aaaaaggagg agcaacctgt ccagaatccc tgcaggacag    240

gaaaaggagg ggaaatctcg acatggaaaa accctacaat aaaaatgaag gaaacctgga    300

aaacgaggga aagccagaag atgaagtaga gcctgatgat gaaggaaagt cagacgagga    360

agaaaagcca gacgtggagg ggaagacaga atgcgaggga aagagagagg atgagggaga    420

gccaggtgat gagggacaac tggaagatga gggaagccag gaaaagcagg gcaggtccga    480

aggtgagggc aagccacaag gcgagggcaa gccagcctcc caggcaaagc cagagagcca    540

gccgcgggcc gccgaaaagc gcccggctga agattatgtg ccccggaaag caaaaagaaa    600

aacggacagg gggacggacg attcccccaa ggactctcag gaggacttac aggaaaggca    660

tctgagcagt gaggagatga tgagagaatg tggagatgtg tcaagggctc aagaggagct    720

aaggaaaaaa cagaaaatgg gtggttttca ttggatgcaa agagatgtac aggatccatt    780

cgccccaagg ggacaacggg gtgtcagggg agtgaggggt ggaggtaggg gccagagggg    840

cttacacgat atcccatacc tttaatgcct ttggccttcc attctgattt ctctgatgag    900

aatattgctg gccctgcttt ccctggtagg tatttgccag gcccaatgct ttaaccttaa    960

gctgatactt tgctttagat gtcagtctcg ttaccagcag ccttttgacc caactacggc   1020

gctctatatt ttagtagagg attttcaccc atgtgcatgg aaaagatgtt catggtacat   1080

tgtaaaaaaa taaaattaaa attaaaaaaa gtttgcagaa ccgcaaaaaa aaaaaaaaaa   1140

aaaaaaaaaa aaaa                                                     1154


<210>  4161
<211>  200
<212>  PRT
<213>  Homosapiens

<400>  4161

Met Glu Lys Pro Tyr Asn Lys Asn Glu Gly Asn Leu Glu Asn Glu Gly 
1               5                   10                  15      


Lys Pro Glu Asp Glu Val Glu Pro Asp Asp Glu Gly Lys Ser Asp Glu 
            20                  25                  30          


Glu Glu Lys Pro Asp Val Glu Gly Lys Thr Glu Cys Glu Gly Lys Arg 
        35                  40                  45              


Glu Asp Glu Gly Glu Pro Gly Asp Glu Gly Gln Leu Glu Asp Glu Gly 
    50                  55                  60                  


Ser Gln Glu Lys Gln Gly Arg Ser Glu Gly Glu Gly Lys Pro Gln Gly 
65                  70                  75                  80  


Glu Gly Lys Pro Ala Ser Gln Ala Lys Pro Glu Ser Gln Pro Arg Ala 
                85                  90                  95      


Ala Glu Lys Arg Pro Ala Glu Asp Tyr Val Pro Arg Lys Ala Lys Arg 
            100                 105                 110         


Lys Thr Asp Arg Gly Thr Asp Asp Ser Pro Lys Asp Ser Gln Glu Asp 
        115                 120                 125             


Leu Gln Glu Arg His Leu Ser Ser Glu Glu Met Met Arg Glu Cys Gly 
    130                 135                 140                 


Asp Val Ser Arg Ala Gln Glu Glu Leu Arg Lys Lys Gln Lys Met Gly 
145                 150                 155                 160 


Gly Phe His Trp Met Gln Arg Asp Val Gln Asp Pro Phe Ala Pro Arg 
                165                 170                 175     


Gly Gln Arg Gly Val Arg Gly Val Arg Gly Gly Gly Arg Gly Gln Arg 
            180                 185                 190         


Gly Leu His Asp Ile Pro Tyr Leu 
        195                 200 


<210>  4162
<211>  1142
<212>  DNA
<213>  Homosapiens

<400>  4162
gtgggcacca gcccccgcgc ccgcccgccc gccctgcggt ccggtcctgg cgcccgcgca     60

gaaccagctg tctgagctgc ccgggcagcg ggggagcagc gagcgggctt ccgcgagccg    120

gagaaggcac aggcctgtcc cgggtcccgg caggtctgcg cgtctgttcc cagcgctctg    180

cgaggcctaa aaaggaggag caacctgtcc agaatccctg caggacagga aaaggagggg    240

aaatctcgac atggaaaaac cctacaataa aaatgaagga aacctggaaa acgagggaaa    300

gccagaagat gaagtagagc ctgatgatga aggaaagtca gacgaggaag aaaagccaga    360

cgtggagggg aagacagaat gcgagggaaa gagagaggat gagggagagc caggtgatga    420

gggacaactg gaagatgagg gaagccagga aaagcagggc aggtccgaag gtgagggcaa    480

gccacaaggc gagggcaagc cagcctccca ggcaaagcca gagagccagc cgcgggccgc    540

cgaaaagcgc ccggctgaag attatgtgcc ccggaaagca aaaagaaaaa cggacagggg    600

gacggacgat tcccccaagg actctcagga ggacttacag gaaaggcatc tgagcagtga    660

ggagatgatg agagaatgtg gagatgtgtc aagggctcaa gaggagctaa ggaaaaaaca    720

gaaaatgggt ggttttcatt ggatgcaaag agatgtacag gatccattcg ccccaagggg    780

acaacggggt gtcaggggag tgaggggtgg aggtaggggc cagaggggct tacacgatat    840

cccatacctt taatgccttt ggccttccat tctgatttct ctgatgagaa tattgctggc    900

cctgctttcc ctggtaggta tttgccaggc ccaatgcttt aaccttaagc tgatactttg    960

ctttagatgt cagtctcgtt accagcagcc ttttgaccca actacggcgc tctatatttt   1020

agtagaggat tttcacccat gtgcatggaa aagatgttca tggtacattg taaaaaaata   1080

aaattaaaat taaaaaaagt ttgcagaacc gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1140

aa                                                                  1142


<210>  4163
<211>  200
<212>  PRT
<213>  Homosapiens

<400>  4163

Met Glu Lys Pro Tyr Asn Lys Asn Glu Gly Asn Leu Glu Asn Glu Gly 
1               5                   10                  15      


Lys Pro Glu Asp Glu Val Glu Pro Asp Asp Glu Gly Lys Ser Asp Glu 
            20                  25                  30          


Glu Glu Lys Pro Asp Val Glu Gly Lys Thr Glu Cys Glu Gly Lys Arg 
        35                  40                  45              


Glu Asp Glu Gly Glu Pro Gly Asp Glu Gly Gln Leu Glu Asp Glu Gly 
    50                  55                  60                  


Ser Gln Glu Lys Gln Gly Arg Ser Glu Gly Glu Gly Lys Pro Gln Gly 
65                  70                  75                  80  


Glu Gly Lys Pro Ala Ser Gln Ala Lys Pro Glu Ser Gln Pro Arg Ala 
                85                  90                  95      


Ala Glu Lys Arg Pro Ala Glu Asp Tyr Val Pro Arg Lys Ala Lys Arg 
            100                 105                 110         


Lys Thr Asp Arg Gly Thr Asp Asp Ser Pro Lys Asp Ser Gln Glu Asp 
        115                 120                 125             


Leu Gln Glu Arg His Leu Ser Ser Glu Glu Met Met Arg Glu Cys Gly 
    130                 135                 140                 


Asp Val Ser Arg Ala Gln Glu Glu Leu Arg Lys Lys Gln Lys Met Gly 
145                 150                 155                 160 


Gly Phe His Trp Met Gln Arg Asp Val Gln Asp Pro Phe Ala Pro Arg 
                165                 170                 175     


Gly Gln Arg Gly Val Arg Gly Val Arg Gly Gly Gly Arg Gly Gln Arg 
            180                 185                 190         


Gly Leu His Asp Ile Pro Tyr Leu 
        195                 200 


<210>  4164
<211>  1208
<212>  DNA
<213>  Homosapiens

<400>  4164
tctttttttt gcctgtccac catctcccta ttaccctttg gtcgagaggg aaagcagaag     60

aagtctgctg gtcacagcgg ggcacctcga ggagaggacg actaggagca cacggcccgg    120

aaaggtccag aataactgtg cttgaagaag aaaattccca acatggacaa accacgcaaa    180

gaaaatgaag aagagccgca gagcgcgccc aagaccgatg aggagaggcc tccggtggag    240

cactctcccg aaaagcagtc ccccgaggag cagtcttcgg aggagcagtc ctcggaggag    300

gagttctttc ctgaggagct cttgcctgag ctcctgcctg agatgctcct ctcggaggag    360

cgccctccgc aggagggtct ttccaggaag gacctgtttg aggggcgccc tcccatggag    420

cagcctcctt gtggagtagg aaaacataag cttgaagaag gaagctttaa agaaaggttg    480

gctcgttctc gcccgcaatt tagaggggac atacatggca gaaatttaag caatgaggag    540

atgatacagg cagcagatga gctagaagag atgaaaagag taagaaacaa actgatgata    600

atgcactgga aggcaaaacg gagccgtcct tatcctattt aatgtgttcg gcctttaatt    660

ctgttttgcc tgctaatagt attgccattg ccacctggac tttctgtttg cattttctta    720

atgccttttc ccatattctg aattttaact ttttgtgagg ctttatttta gatgtttagc    780

atgtaactcg cttaaagttg aggtttcccc ctaaaatcta caagtttccc tctttcagtc    840

atgagcccta cacatttgca tgaaagatgt acattatata ttgtgaaacg aaaaaagcaa    900

ttttcaaatg gtatatattg tatcccattt ttgtaaaaaa aatgtatatt tatatattaa    960

tatgcaaaga aaaagctaaa agtatagact tcaaaggcat aacagtggtt gtgtggtaag   1020

ataataggtg attttttaaa tttttgtttt atctgaattt ctcatttttt caggacaaac   1080

gttttacttg tgttgcaaaa atatataatg aaaaaatcac acaattttga agaaaactgt   1140

caatcagctt ataacgacaa tgtggcactt aataaatact tgtcagaact ttaaaaaaaa   1200

aaaaaaaa                                                            1208


<210>  4165
<211>  159
<212>  PRT
<213>  Homosapiens

<400>  4165

Met Asp Lys Pro Arg Lys Glu Asn Glu Glu Glu Pro Gln Ser Ala Pro 
1               5                   10                  15      


Lys Thr Asp Glu Glu Arg Pro Pro Val Glu His Ser Pro Glu Lys Gln 
            20                  25                  30          


Ser Pro Glu Glu Gln Ser Ser Glu Glu Gln Ser Ser Glu Glu Glu Phe 
        35                  40                  45              


Phe Pro Glu Glu Leu Leu Pro Glu Leu Leu Pro Glu Met Leu Leu Ser 
    50                  55                  60                  


Glu Glu Arg Pro Pro Gln Glu Gly Leu Ser Arg Lys Asp Leu Phe Glu 
65                  70                  75                  80  


Gly Arg Pro Pro Met Glu Gln Pro Pro Cys Gly Val Gly Lys His Lys 
                85                  90                  95      


Leu Glu Glu Gly Ser Phe Lys Glu Arg Leu Ala Arg Ser Arg Pro Gln 
            100                 105                 110         


Phe Arg Gly Asp Ile His Gly Arg Asn Leu Ser Asn Glu Glu Met Ile 
        115                 120                 125             


Gln Ala Ala Asp Glu Leu Glu Glu Met Lys Arg Val Arg Asn Lys Leu 
    130                 135                 140                 


Met Ile Met His Trp Lys Ala Lys Arg Ser Arg Pro Tyr Pro Ile 
145                 150                 155                 


<210>  4166
<211>  1220
<212>  DNA
<213>  Homosapiens

<400>  4166
aggaagaggc aatactaccc gagactagat gcggaccgtc tctggcaacc aggaaaaggc     60

aaatacaaag agaggtctgc tggtcacagc ggggcacctc gaggagagga cgactaggag    120

cacacggccc ggaaaggtcc agaataactg tgcttgaaga agaaaattcc caacatggac    180

aaaccacgca aagaaaatga agaagagccg cagagcgcgc ccaagaccga tgaggagagg    240

cctccggtgg agcactctcc cgaaaagcag tcccccgagg agcagtcttc ggaggagcag    300

tcctcggagg aggagttctt tcctgaggag ctcttgcctg agctcctgcc tgagatgctc    360

ctctcggagg agcgccctcc gcaggagggt ctttccagga aggacctgtt tgaggggcgc    420

cctcccatgg agcagcctcc ttgtggagta ggaaaacata agcttgaaga aggaagcttt    480

aaagaaaggt tggctcgttc tcgcccgcaa tttagagggg acatacatgg cagaaattta    540

agcaatgagg agatgataca ggcagcagat gagctagaag agatgaaaag agtaagaaac    600

aaactgatga taatgcactg gaaggcaaaa cggagccgtc cttatcctat ttaatgtgtt    660

cggcctttaa ttctgttttg cctgctaata gtattgccat tgccacctgg actttctgtt    720

tgcattttct taatgccttt tcccatattc tgaattttaa ctttttgtga ggctttattt    780

tagatgttta gcatgtaact cgcttaaagt tgaggtttcc ccctaaaatc tacaagtttc    840

cctctttcag tcatgagccc tacacatttg catgaaagat gtacattata tattgtgaaa    900

cgaaaaaagc aattttcaaa tggtatatat tgtatcccat ttttgtaaaa aaaatgtata    960

tttatatatt aatatgcaaa gaaaaagcta aaagtataga cttcaaaggc ataacagtgg   1020

ttgtgtggta agataatagg tgatttttta aatttttgtt ttatctgaat ttctcatttt   1080

ttcaggacaa acgttttact tgtgttgcaa aaatatataa tgaaaaaatc acacaatttt   1140

gaagaaaact gtcaatcagc ttataacgac aatgtggcac ttaataaata cttgtcagaa   1200

ctttaaaaaa aaaaaaaaaa                                               1220


<210>  4167
<211>  159
<212>  PRT
<213>  Homosapiens

<400>  4167

Met Asp Lys Pro Arg Lys Glu Asn Glu Glu Glu Pro Gln Ser Ala Pro 
1               5                   10                  15      


Lys Thr Asp Glu Glu Arg Pro Pro Val Glu His Ser Pro Glu Lys Gln 
            20                  25                  30          


Ser Pro Glu Glu Gln Ser Ser Glu Glu Gln Ser Ser Glu Glu Glu Phe 
        35                  40                  45              


Phe Pro Glu Glu Leu Leu Pro Glu Leu Leu Pro Glu Met Leu Leu Ser 
    50                  55                  60                  


Glu Glu Arg Pro Pro Gln Glu Gly Leu Ser Arg Lys Asp Leu Phe Glu 
65                  70                  75                  80  


Gly Arg Pro Pro Met Glu Gln Pro Pro Cys Gly Val Gly Lys His Lys 
                85                  90                  95      


Leu Glu Glu Gly Ser Phe Lys Glu Arg Leu Ala Arg Ser Arg Pro Gln 
            100                 105                 110         


Phe Arg Gly Asp Ile His Gly Arg Asn Leu Ser Asn Glu Glu Met Ile 
        115                 120                 125             


Gln Ala Ala Asp Glu Leu Glu Glu Met Lys Arg Val Arg Asn Lys Leu 
    130                 135                 140                 


Met Ile Met His Trp Lys Ala Lys Arg Ser Arg Pro Tyr Pro Ile 
145                 150                 155                 


<210>  4168
<211>  1220
<212>  DNA
<213>  Homosapiens

<400>  4168
tctttttttt gcctgtccac catctcccta ttaccctttg gtcgagaggg aaagcagaag     60

aagtctgctg gtcacagcgg ggcacctcga ggagaggacg actaggagca cacggcccgg    120

aaaggtccag gtcagggaag ggaataactg tgcttgaaga agaaaattcc caacatggac    180

aaaccacgca aagaaaatga agaagagccg cagagcgcgc ccaagaccga tgaggagagg    240

cctccggtgg agcactctcc cgaaaagcag tcccccgagg agcagtcttc ggaggagcag    300

tcctcggagg aggagttctt tcctgaggag ctcttgcctg agctcctgcc tgagatgctc    360

ctctcggagg agcgccctcc gcaggagggt ctttccagga aggacctgtt tgaggggcgc    420

cctcccatgg agcagcctcc ttgtggagta ggaaaacata agcttgaaga aggaagcttt    480

aaagaaaggt tggctcgttc tcgcccgcaa tttagagggg acatacatgg cagaaattta    540

agcaatgagg agatgataca ggcagcagat gagctagaag agatgaaaag agtaagaaac    600

aaactgatga taatgcactg gaaggcaaaa cggagccgtc cttatcctat ttaatgtgtt    660

cggcctttaa ttctgttttg cctgctaata gtattgccat tgccacctgg actttctgtt    720

tgcattttct taatgccttt tcccatattc tgaattttaa ctttttgtga ggctttattt    780

tagatgttta gcatgtaact cgcttaaagt tgaggtttcc ccctaaaatc tacaagtttc    840

cctctttcag tcatgagccc tacacatttg catgaaagat gtacattata tattgtgaaa    900

cgaaaaaagc aattttcaaa tggtatatat tgtatcccat ttttgtaaaa aaaatgtata    960

tttatatatt aatatgcaaa gaaaaagcta aaagtataga cttcaaaggc ataacagtgg   1020

ttgtgtggta agataatagg tgatttttta aatttttgtt ttatctgaat ttctcatttt   1080

ttcaggacaa acgttttact tgtgttgcaa aaatatataa tgaaaaaatc acacaatttt   1140

gaagaaaact gtcaatcagc ttataacgac aatgtggcac ttaataaata cttgtcagaa   1200

ctttaaaaaa aaaaaaaaaa                                               1220


<210>  4169
<211>  159
<212>  PRT
<213>  Homosapiens

<400>  4169

Met Asp Lys Pro Arg Lys Glu Asn Glu Glu Glu Pro Gln Ser Ala Pro 
1               5                   10                  15      


Lys Thr Asp Glu Glu Arg Pro Pro Val Glu His Ser Pro Glu Lys Gln 
            20                  25                  30          


Ser Pro Glu Glu Gln Ser Ser Glu Glu Gln Ser Ser Glu Glu Glu Phe 
        35                  40                  45              


Phe Pro Glu Glu Leu Leu Pro Glu Leu Leu Pro Glu Met Leu Leu Ser 
    50                  55                  60                  


Glu Glu Arg Pro Pro Gln Glu Gly Leu Ser Arg Lys Asp Leu Phe Glu 
65                  70                  75                  80  


Gly Arg Pro Pro Met Glu Gln Pro Pro Cys Gly Val Gly Lys His Lys 
                85                  90                  95      


Leu Glu Glu Gly Ser Phe Lys Glu Arg Leu Ala Arg Ser Arg Pro Gln 
            100                 105                 110         


Phe Arg Gly Asp Ile His Gly Arg Asn Leu Ser Asn Glu Glu Met Ile 
        115                 120                 125             


Gln Ala Ala Asp Glu Leu Glu Glu Met Lys Arg Val Arg Asn Lys Leu 
    130                 135                 140                 


Met Ile Met His Trp Lys Ala Lys Arg Ser Arg Pro Tyr Pro Ile 
145                 150                 155                 


<210>  4170
<211>  1826
<212>  DNA
<213>  Homosapiens

<400>  4170
cacgtcggct gctgggaaga tctggattct cgtttcaggt caccatcaga aaagctaagt     60

ttgctgtata gtgaggatca ggagatctga tcctgattgc agaaccttcc ctgattacag    120

aatcttggat gatttcacaa aagttcatct tcattgcaga tacctgcctt tctttctagg    180

ttgtatctcc cacttcaccc ttctagacca tcccagaaga tctataagat ttcatctggg    240

aaatcactag gagttcttgg aagggaaaga aggaagattg ttggttggaa taaaaacagg    300

gttgaatgag ttccagaaag cagggttctc aacctcgtgg acagcaatct gcagaagaag    360

agaacttcaa aaaaccaact agaagcaaca tgcagagaag taaaatgaga ggggcctcct    420

caggaaagaa gacagctggt ccacagcaga aaaatcttga accagctctc ccaggaagat    480

ggggtggtcg ctctgcagag aacccccctt caggatccgt gaggaagacc agaaagaaca    540

agcagaagac tcctggaaac ggagatggtg gcagtaccag cgaagcacct cagccccctc    600

ggaagaaaag ggcccgggca gaccccactg ttgaaagtga ggaggcgttt aagaatagaa    660

tggaggttaa agtgaagatt cctgaagaat taaaaccatg gcttgttgag gactgggact    720

tagttaccag gcagaagcag ctgtttcaac tccctgccaa gaaaaatgta gatgcaattc    780

tggaggagta tgcaaattgc aagaaatcgc agggaaatgt tgataataag gaatatgcgg    840

ttaatgaagt tgtggcagga ataaaagaat atttcaatgt gatgttgggc actcagctgc    900

tctacaaatt tgagaggccc cagtatgctg aaatcctctt ggctcaccct gatgctccaa    960

tgtcccaggt ttatggagca ccacacctac tgagattatt tgtaagaatt ggagcaatgt   1020

tggcctatac gccccttgat gagaaaagcc ttgcattatt gttgggctat ttgcatgatt   1080

tcctaaaata tctggcaaag aattctgcat ctctctttac tgccagtgat tacaaagtgg   1140

cttctgctga gtaccaccgc aaagccctgt gagcgtctac agacagctca ccatttttgt   1200

cctgtatctg taaacacttt ttgttcttag tctttttctt gtaaaattga tgttctttaa   1260

aatcgttaat gtataacagg gcttatgttt cagtttgttt tccgttctgt tttaaacaga   1320

aaataaaagg agtgtaagct ccttttctca tttcaaagtt gctaccagtg tatgcagtaa   1380

ttagaacaaa gaagaaacat tcagtagaac attttattgc ctagttgaca acattgcttg   1440

aatgctggtg gttcctatcc ctttgacact acacaatttt ctaatatgtg ttaatgctat   1500

gtgacaaaac gccctgattc ctagtgccaa aggttcaact taatgtatat acctgaaaac   1560

ccatgcattt gtgctctttt tttttttatg gtgcttgaag taaaacagcc catcctctgc   1620

aagtccatct atgttgttct taggcattct atctttgctc aaattgttga aggatggtga   1680

tttgtttcat ggtttttgta tttgagtcta atgcacgttc taacatgata gaggcaatgc   1740

attattgtgt agccacggtt ttctggaaaa gttgatattt taggaattgt atttcagatc   1800

ttaaataaaa tttgtttcta aatttc                                        1826


<210>  4171
<211>  288
<212>  PRT
<213>  Homosapiens

<400>  4171

Met Ser Ser Arg Lys Gln Gly Ser Gln Pro Arg Gly Gln Gln Ser Ala 
1               5                   10                  15      


Glu Glu Glu Asn Phe Lys Lys Pro Thr Arg Ser Asn Met Gln Arg Ser 
            20                  25                  30          


Lys Met Arg Gly Ala Ser Ser Gly Lys Lys Thr Ala Gly Pro Gln Gln 
        35                  40                  45              


Lys Asn Leu Glu Pro Ala Leu Pro Gly Arg Trp Gly Gly Arg Ser Ala 
    50                  55                  60                  


Glu Asn Pro Pro Ser Gly Ser Val Arg Lys Thr Arg Lys Asn Lys Gln 
65                  70                  75                  80  


Lys Thr Pro Gly Asn Gly Asp Gly Gly Ser Thr Ser Glu Ala Pro Gln 
                85                  90                  95      


Pro Pro Arg Lys Lys Arg Ala Arg Ala Asp Pro Thr Val Glu Ser Glu 
            100                 105                 110         


Glu Ala Phe Lys Asn Arg Met Glu Val Lys Val Lys Ile Pro Glu Glu 
        115                 120                 125             


Leu Lys Pro Trp Leu Val Glu Asp Trp Asp Leu Val Thr Arg Gln Lys 
    130                 135                 140                 


Gln Leu Phe Gln Leu Pro Ala Lys Lys Asn Val Asp Ala Ile Leu Glu 
145                 150                 155                 160 


Glu Tyr Ala Asn Cys Lys Lys Ser Gln Gly Asn Val Asp Asn Lys Glu 
                165                 170                 175     


Tyr Ala Val Asn Glu Val Val Ala Gly Ile Lys Glu Tyr Phe Asn Val 
            180                 185                 190         


Met Leu Gly Thr Gln Leu Leu Tyr Lys Phe Glu Arg Pro Gln Tyr Ala 
        195                 200                 205             


Glu Ile Leu Leu Ala His Pro Asp Ala Pro Met Ser Gln Val Tyr Gly 
    210                 215                 220                 


Ala Pro His Leu Leu Arg Leu Phe Val Arg Ile Gly Ala Met Leu Ala 
225                 230                 235                 240 


Tyr Thr Pro Leu Asp Glu Lys Ser Leu Ala Leu Leu Leu Gly Tyr Leu 
                245                 250                 255     


His Asp Phe Leu Lys Tyr Leu Ala Lys Asn Ser Ala Ser Leu Phe Thr 
            260                 265                 270         


Ala Ser Asp Tyr Lys Val Ala Ser Ala Glu Tyr His Arg Lys Ala Leu 
        275                 280                 285             


<210>  4172
<211>  732
<212>  DNA
<213>  Homosapiens

<400>  4172
aggcagttgc gggttgcagg agttcaggaa aggaggtggg actagagtca acctggaata     60

gctctacagt aacaatggca gcctttttgt tgctgggaca tccatacagg caacttagct    120

ggtgaaagga ctctggattg gttggcagtc tgcttttttt tttccaaggt gatcacttta    180

ctgtagaaga aatgaggtta acagaaaaga gtgagggaga acaacaactc aagcccaaca    240

actctaatgc acccaatgaa gatcaagaag aagaaatcca acagtcagaa cagcatactc    300

cagcaaggca gcgaacacaa agagcagaca cacagccatc cagatgtcga ttgccttcac    360

gtaggacacc tacaacatcc agcgacagaa cgatcaacct tcttgaagtc cttccgtggc    420

ctactgagtg gattttcaac ccctatcgat tgcctgctct ttttgagctt tatcctgaat    480

ttcttctggt gtttaaagaa gccttccatg acatatccca ttgtctgaaa gcccagatgg    540

aaaagatcgg actgcccatc atactccacc tcttcgcact ctccaccctc tacttctaca    600

agtttttcct tcctacaatt ctttcccttt ctttctttat tcttcttgta cttctgcttc    660

tgctttttat tattgtcttc attctgatct tcttctgatt cttttgtttc aataaacagc    720

aatgagcatg aa                                                        732


<210>  4173
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  4173

Met Arg Leu Thr Glu Lys Ser Glu Gly Glu Gln Gln Leu Lys Pro Asn 
1               5                   10                  15      


Asn Ser Asn Ala Pro Asn Glu Asp Gln Glu Glu Glu Ile Gln Gln Ser 
            20                  25                  30          


Glu Gln His Thr Pro Ala Arg Gln Arg Thr Gln Arg Ala Asp Thr Gln 
        35                  40                  45              


Pro Ser Arg Cys Arg Leu Pro Ser Arg Arg Thr Pro Thr Thr Ser Ser 
    50                  55                  60                  


Asp Arg Thr Ile Asn Leu Leu Glu Val Leu Pro Trp Pro Thr Glu Trp 
65                  70                  75                  80  


Ile Phe Asn Pro Tyr Arg Leu Pro Ala Leu Phe Glu Leu Tyr Pro Glu 
                85                  90                  95      


Phe Leu Leu Val Phe Lys Glu Ala Phe His Asp Ile Ser His Cys Leu 
            100                 105                 110         


Lys Ala Gln Met Glu Lys Ile Gly Leu Pro Ile Ile Leu His Leu Phe 
        115                 120                 125             


Ala Leu Ser Thr Leu Tyr Phe Tyr Lys Phe Phe Leu Pro Thr Ile Leu 
    130                 135                 140                 


Ser Leu Ser Phe Phe Ile Leu Leu Val Leu Leu Leu Leu Leu Phe Ile 
145                 150                 155                 160 


Ile Val Phe Ile Leu Ile Phe Phe 
                165             


<210>  4174
<211>  3038
<212>  DNA
<213>  Homosapiens

<400>  4174
tcaatcagaa agcccttttc attgcaggag aagaggacaa agatactcag agagaaaaag     60

taaaagaccg aagaaggagg ctggagagac caggatcctt ccagctgaac aaagtcagcc    120

acaaagcaga ctagccagcc ggctacaatt ggagtcagag tcccaaagac atgggcttgt    180

tagagtgctg tgcaagatgt ctggtagggg ccccctttgc ttccctggtg gccactggat    240

tgtgtttctt tggggtggca ctgttctgtg gctgtggaca tgaagccctc actggcacag    300

aaaagctaat tgagacctat ttctccaaaa actaccaaga ctatgagtat ctcatcaatg    360

tgatccatgc cttccagtat gtcatctatg gaactgcctc tttcttcttc ctttatgggg    420

ccctcctgct ggctgagggc ttctacacca ccggcgcagt caggcagatc tttggcgact    480

acaagaccac catctgcggc aagggcctga gcgcaacggt aacagggggc cagaagggga    540

ggggttccag aggccaacat caagctcatt ctttggagcg ggtgtgtcat tgtttgggaa    600

aatggctagg acatcccgac aagtttgtgg gcatcaccta tgccctgacc gttgtgtggc    660

tcctggtgtt tgcctgctct gctgtgcctg tgtacattta cttcaacacc tggaccacct    720

gccagtctat tgccttcccc agcaagacct ctgccagtat aggcagtctc tgtgctgatg    780

ccagaatgta tggtgttctc ccatggaatg ctttccctgg caaggtttgt ggctccaacc    840

ttctgtccat ctgcaaaaca gctgagttcc aaatgacctt ccacctgttt attgctgcat    900

ttgtgggggc tgcagctaca ctggtttccc tgctcacctt catgattgct gccacttaca    960

actttgccgt ccttaaactc atgggccgag gcaccaagtt ctgatccccc gtagaaatcc   1020

ccctttctct aatagcgagg ctctaaccac acagcctaca atgctgcgtc tcccatctta   1080

actctttgcc tttgccacca actggccctc ttcttacttg atgagtgtaa caagaaagga   1140

gagtcttgca gtgattaagg tctctctttg gactctcccc tcttatgtac ctcttttagt   1200

cattttgctt catagctggt tcctgctaga aatgggaaat gcctaagaag atgacttccc   1260

aactgcaagt cacaaaggaa tggaggctct aattgaattt tcaagcatct cctgaggatc   1320

agaaagtaat ttcttctcaa agggtacttc cactgatgga aacaaagtgg aaggaaagat   1380

gctcaggtac agagaaggaa tgtctttggt cctcttgcca tctatagggg ccaaatatat   1440

tctctttggt gtacaaaatg gaattcattc tggtctctct attaccactg aagatagaag   1500

aaaaaagaat gtcagaaaaa caataagagc gtttgcccaa atctgcctat tgcagctggg   1560

agaagggggt caaagcaagg atctttcacc cacagaaaga gagcactgac cccgatggcg   1620

atggactact gaagccctaa ctcagccaac cttacttaca gcataaggga gcgtagaatc   1680

tgtgtagacg aagggggcat ctggccttac acctcgttag ggaagagaaa cagggtgttg   1740

tcagcatctt ctcactccct tctccttgat aacagctacc atgacaaccc tgtggtttcc   1800

aaggagctga gaatagaagg aaactagctt acatgagaac agactggcct gaggagcagc   1860

agttgctggt ggctaatggt gtaacctgag atggccctct ggtagacaca ggatagataa   1920

ctctttggat agcatgtctt tttttctgtt aattagttgt gtactctggc ctctgtcata   1980

tcttcacaat ggtgctcatt tcatgggggt attatccatt cagtcatcgt aggtgatttg   2040

aaggtcttga tttgttttag aatgatgcac atttcatgta ttccagtttg tttattactt   2100

atttggggtt gcatcagaaa tgtctggaga ataattcttt gattatgact gttttttaaa   2160

ctaggaaaat tggacattaa gcatcacaaa tgatattaaa aattggctag ttgaatctat   2220

tgggattttc tacaagtatt ctgcctttgc agaaacagat ttggtgaatt tgaatctcaa   2280

tttgagtaat ctgatcgttc tttctagcta atggaaaatg attttactta gcaatgttat   2340

cttggtgtgt taagagttag gtttaacata aaggttattt tctcctgata tagatcacat   2400

aacagaatgc accagtcatc agctattcag ttggtaagct tccaggaaaa aggacaggca   2460

gaaagagttt gagacctgaa tagctcccag atttcagtct tttcctgttt ttgttaactt   2520

tgggttaaaa aaaaaaaaag tctgattggt tttaattgaa ggaaagattt gtactacagt   2580

tcttttgttg taaagagttg tgttgttctt ttcccccaaa gtggtttcag caatatttaa   2640

ggagatgtaa gagctttaca aaaagacact tgatacttgt tttcaaacca gtatacaaga   2700

taagcttcca ggctgcatag aaggaggaga gggaaaatgt tttgtaagaa accaatcaag   2760

ataaaggaca gtgaagtaat ccgtaccttg tgttttgttt tgatttaata acataacaaa   2820

taaccaaccc ttccctgaaa acctcacatg catacataca catatataca cacacaaaga   2880

gagttaatca actgaaagtg tttccttcat ttctgatata gaattgcaat tttaacacac   2940

ataaaggata aacttttaga aacttatctt acaaagtgta ttttataaaa ttaaagaaaa   3000

taaaattaag aatgttctca atcaaaaaaa aaaaaaaa                           3038


<210>  4175
<211>  277
<212>  PRT
<213>  Homosapiens

<400>  4175

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  4176
<211>  2933
<212>  DNA
<213>  Homosapiens

<400>  4176
tcaatcagaa agcccttttc attgcaggag aagaggacaa agatactcag agagaaaaag     60

taaaagaccg aagaaggagg ctggagagac caggatcctt ccagctgaac aaagtcagcc    120

acaaagcaga ctagccagcc ggctacaatt ggagtcagag tcccaaagac atgggcttgt    180

tagagtgctg tgcaagatgt ctggtagggg ccccctttgc ttccctggtg gccactggat    240

tgtgtttctt tggggtggca ctgttctgtg gctgtggaca tgaagccctc actggcacag    300

aaaagctaat tgagacctat ttctccaaaa actaccaaga ctatgagtat ctcatcaatg    360

tgatccatgc cttccagtat gtcatctatg gaactgcctc tttcttcttc ctttatgggg    420

ccctcctgct ggctgagggc ttctacacca ccggcgcagt caggcagatc tttggcgact    480

acaagaccac catctgcggc aagggcctga gcgcaacgtt tgtgggcatc acctatgccc    540

tgaccgttgt gtggctcctg gtgtttgcct gctctgctgt gcctgtgtac atttacttca    600

acacctggac cacctgccag tctattgcct tccccagcaa gacctctgcc agtataggca    660

gtctctgtgc tgatgccaga atgtatggtg ttctcccatg gaatgctttc cctggcaagg    720

tttgtggctc caaccttctg tccatctgca aaacagctga gttccaaatg accttccacc    780

tgtttattgc tgcatttgtg ggggctgcag ctacactggt ttccctgctc accttcatga    840

ttgctgccac ttacaacttt gccgtcctta aactcatggg ccgaggcacc aagttctgat    900

cccccgtaga aatccccctt tctctaatag cgaggctcta accacacagc ctacaatgct    960

gcgtctccca tcttaactct ttgcctttgc caccaactgg ccctcttctt acttgatgag   1020

tgtaacaaga aaggagagtc ttgcagtgat taaggtctct ctttggactc tcccctctta   1080

tgtacctctt ttagtcattt tgcttcatag ctggttcctg ctagaaatgg gaaatgccta   1140

agaagatgac ttcccaactg caagtcacaa aggaatggag gctctaattg aattttcaag   1200

catctcctga ggatcagaaa gtaatttctt ctcaaagggt acttccactg atggaaacaa   1260

agtggaagga aagatgctca ggtacagaga aggaatgtct ttggtcctct tgccatctat   1320

aggggccaaa tatattctct ttggtgtaca aaatggaatt cattctggtc tctctattac   1380

cactgaagat agaagaaaaa agaatgtcag aaaaacaata agagcgtttg cccaaatctg   1440

cctattgcag ctgggagaag ggggtcaaag caaggatctt tcacccacag aaagagagca   1500

ctgaccccga tggcgatgga ctactgaagc cctaactcag ccaaccttac ttacagcata   1560

agggagcgta gaatctgtgt agacgaaggg ggcatctggc cttacacctc gttagggaag   1620

agaaacaggg tgttgtcagc atcttctcac tcccttctcc ttgataacag ctaccatgac   1680

aaccctgtgg tttccaagga gctgagaata gaaggaaact agcttacatg agaacagact   1740

ggcctgagga gcagcagttg ctggtggcta atggtgtaac ctgagatggc cctctggtag   1800

acacaggata gataactctt tggatagcat gtcttttttt ctgttaatta gttgtgtact   1860

ctggcctctg tcatatcttc acaatggtgc tcatttcatg ggggtattat ccattcagtc   1920

atcgtaggtg atttgaaggt cttgatttgt tttagaatga tgcacatttc atgtattcca   1980

gtttgtttat tacttatttg gggttgcatc agaaatgtct ggagaataat tctttgatta   2040

tgactgtttt ttaaactagg aaaattggac attaagcatc acaaatgata ttaaaaattg   2100

gctagttgaa tctattggga ttttctacaa gtattctgcc tttgcagaaa cagatttggt   2160

gaatttgaat ctcaatttga gtaatctgat cgttctttct agctaatgga aaatgatttt   2220

acttagcaat gttatcttgg tgtgttaaga gttaggttta acataaaggt tattttctcc   2280

tgatatagat cacataacag aatgcaccag tcatcagcta ttcagttggt aagcttccag   2340

gaaaaaggac aggcagaaag agtttgagac ctgaatagct cccagatttc agtcttttcc   2400

tgtttttgtt aactttgggt taaaaaaaaa aaaagtctga ttggttttaa ttgaaggaaa   2460

gatttgtact acagttcttt tgttgtaaag agttgtgttg ttcttttccc ccaaagtggt   2520

ttcagcaata tttaaggaga tgtaagagct ttacaaaaag acacttgata cttgttttca   2580

aaccagtata caagataagc ttccaggctg catagaagga ggagagggaa aatgttttgt   2640

aagaaaccaa tcaagataaa ggacagtgaa gtaatccgta ccttgtgttt tgttttgatt   2700

taataacata acaaataacc aacccttccc tgaaaacctc acatgcatac atacacatat   2760

atacacacac aaagagagtt aatcaactga aagtgtttcc ttcatttctg atatagaatt   2820

gcaattttaa cacacataaa ggataaactt ttagaaactt atcttacaaa gtgtatttta   2880

taaaattaaa gaaaataaaa ttaagaatgt tctcaatcaa aaaaaaaaaa aaa          2933


<210>  4177
<211>  242
<212>  PRT
<213>  Homosapiens

<400>  4177

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Phe Val Gly Ile Thr Tyr Ala Leu Thr Val Val Trp 
        115                 120                 125             


Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn 
    130                 135                 140                 


Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala 
145                 150                 155                 160 


Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu Pro 
                165                 170                 175     


Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser Ile 
            180                 185                 190         


Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe Ile Ala Ala 
        195                 200                 205             


Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr Phe Met Ile 
    210                 215                 220                 


Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg Gly Thr 
225                 230                 235                 240 


Lys Phe 
        


<210>  4178
<211>  1049
<212>  DNA
<213>  Homosapiens

<400>  4178
cgagcggcac gtgtcaggcc accgaggtcc aagccgcact tgctgcccca ttgaggacga     60

ggaggcagca ggagcagtga cggtgactct aaggagccgg attcccggca cgcagagctg    120

acctgcctgg cacccgcggc cctctcctgt ttccttccca ttgtgttggc accctaaaaa    180

gaaagaataa aacaacaaca ggaaaaaaag gaaaatattt aaattgtgac aaaaacccac    240

tgggttctct tggttacaaa ctccttccct tctggtgctg caaaaatgag tgggaaatcc    300

ctgctcttaa aggtcattct cttgggtgat ggtggagttg ggaaaagttc gcttatgaac    360

cgttacgtaa ccaacaaatt tgactcccag gcttttcaca ccataggggt agagttctta    420

aatcgagatc tggaggtaga tggacgcttt gtaaccctcc agatctggga cactgcaggg    480

caggaacgtt tcaagagcct taggacaccc ttctacaggg gagcagactg ctgcctcttg    540

accttcagcg tggatgatcg gcagagcttc gagaatcttg gtaactggca gaaagaattt    600

atttactatg cggatgtgaa ggaccctgag catttcccct ttgtagttct gggtaacaag    660

gtagacaaag aggataggca agtgactact gaggaggcac aaacctggtg catggagaat    720

ggggattacc cttatttaga aactagtgcc aaagatgata ctaatgtgac agtggccttt    780

gaagaagctg tcaggcaggt gctggctgta gaggaacagc tggagcattg catgttgggt    840

cacaccattg acttgaacag tggctccaaa gcagggtctt cgtgctgtta aagataggga    900

gccttttaaa aatgtgcccc aaattgatca gtcagtagtg taagaataac tgtgcccctc    960

taagagtgca cacacacgca cacaagaggg taagagacaa ggttctgatt gtgaaacaga   1020

gcctttcaaa ttgaagtgta gattgattt                                     1049


<210>  4179
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  4179

Met Ser Gly Lys Ser Leu Leu Leu Lys Val Ile Leu Leu Gly Asp Gly 
1               5                   10                  15      


Gly Val Gly Lys Ser Ser Leu Met Asn Arg Tyr Val Thr Asn Lys Phe 
            20                  25                  30          


Asp Ser Gln Ala Phe His Thr Ile Gly Val Glu Phe Leu Asn Arg Asp 
        35                  40                  45              


Leu Glu Val Asp Gly Arg Phe Val Thr Leu Gln Ile Trp Asp Thr Ala 
    50                  55                  60                  


Gly Gln Glu Arg Phe Lys Ser Leu Arg Thr Pro Phe Tyr Arg Gly Ala 
65                  70                  75                  80  


Asp Cys Cys Leu Leu Thr Phe Ser Val Asp Asp Arg Gln Ser Phe Glu 
                85                  90                  95      


Asn Leu Gly Asn Trp Gln Lys Glu Phe Ile Tyr Tyr Ala Asp Val Lys 
            100                 105                 110         


Asp Pro Glu His Phe Pro Phe Val Val Leu Gly Asn Lys Val Asp Lys 
        115                 120                 125             


Glu Asp Arg Gln Val Thr Thr Glu Glu Ala Gln Thr Trp Cys Met Glu 
    130                 135                 140                 


Asn Gly Asp Tyr Pro Tyr Leu Glu Thr Ser Ala Lys Asp Asp Thr Asn 
145                 150                 155                 160 


Val Thr Val Ala Phe Glu Glu Ala Val Arg Gln Val Leu Ala Val Glu 
                165                 170                 175     


Glu Gln Leu Glu His Cys Met Leu Gly His Thr Ile Asp Leu Asn Ser 
            180                 185                 190         


Gly Ser Lys Ala Gly Ser Ser Cys Cys 
        195                 200     


<210>  4180
<211>  1308
<212>  DNA
<213>  Homosapiens

<400>  4180
atggggtttg atttctcaca cttcttcatc aagcatggct tgaagaagga agacattatg     60

acagacccat ttgaaaatct gcaaagctgt ggactcagaa gaatgtacgg agtccagatt    120

ctttgcatac agttccagga aggaccgcgg caaccgcggc tgcccggagg tccgaactgg    180

agggtggccg cagccgtgac ttccttggga accgcgctgc ctcgactcgg ctacctctct    240

gcgaagcact cgctaagccg ggcagccccg gggtcgctta gcggcccagg aggcgccagc    300

gatcctgttc ccctgcagag ctatggggac cggaaggcga aacagagctg tcgacgcggg    360

agcatacgct gcccaccagt ggagcgcagg tcatcaaagc cgaatccgaa tttgaattct    420

gtgcggctga ttgcagagct ggtaggccga cggtttcccg caggaaatgt ctcctactac    480

taccaaatct gtatcagcaa cagcagcagc tccaaggaca gtatgtgtgg caatgcaagt    540

acctgctgtc atgacatcag aaaatttcaa ctatggcggt tgaaagaacc agcggaactt    600

caccaccaag gggctgcagt tggtgatggt aacctagcga atgacctcag tattgttcag    660

gatgcagcca aaatccagct ccatcatctc aaagctgagg ttggggtaga tcgccccaaa    720

cccccttcaa ggacagattt tctgcttcag ctgctgggac agcagttgga tgccagtcat    780

cagccatcag ttccttcaga cctcaagttg gcccacaatg tcagccatgt ggtgactaca    840

aaaggccctc ccactggtga tcagcagctt atctgttcct cctatccact ggcagctgcc    900

tccaagatgg ctgagccttc ctctgagatg acctccaaca aaggcctgag caccaaggag    960

cccaaagcgg ccaatgccac gatggcccac aagcagaaga ggcatgggca ctctcacccc   1020

agccgctgca gggacagctt caccacctat tttccccggg tgctgaagca ggttcacgcg   1080

ggcctcagcc tttcccccga ggcagtggat gtcatagatt ccttcgttca cgacatcttg   1140

gagcacatcg ccaccaaggc cggccacttg gcccactata ccaagtgcac caccatcacc   1200

tcctgcgaga tgcagaccac cattcgcctg atgttcccgg ggcagatggg caagcacgcc   1260

atatccaggg gctccaagac tctgctccac tacaccagga gcaagtga                1308


<210>  4181
<211>  435
<212>  PRT
<213>  Homosapiens

<400>  4181

Met Gly Phe Asp Phe Ser His Phe Phe Ile Lys His Gly Leu Lys Lys 
1               5                   10                  15      


Glu Asp Ile Met Thr Asp Pro Phe Glu Asn Leu Gln Ser Cys Gly Leu 
            20                  25                  30          


Arg Arg Met Tyr Gly Val Gln Ile Leu Cys Ile Gln Phe Gln Glu Gly 
        35                  40                  45              


Pro Arg Gln Pro Arg Leu Pro Gly Gly Pro Asn Trp Arg Val Ala Ala 
    50                  55                  60                  


Ala Val Thr Ser Leu Gly Thr Ala Leu Pro Arg Leu Gly Tyr Leu Ser 
65                  70                  75                  80  


Ala Lys His Ser Leu Ser Arg Ala Ala Pro Gly Ser Leu Ser Gly Pro 
                85                  90                  95      


Gly Gly Ala Ser Asp Pro Val Pro Leu Gln Ser Tyr Gly Asp Arg Lys 
            100                 105                 110         


Ala Lys Gln Ser Cys Arg Arg Gly Ser Ile Arg Cys Pro Pro Val Glu 
        115                 120                 125             


Arg Arg Ser Ser Lys Pro Asn Pro Asn Leu Asn Ser Val Arg Leu Ile 
    130                 135                 140                 


Ala Glu Leu Val Gly Arg Arg Phe Pro Ala Gly Asn Val Ser Tyr Tyr 
145                 150                 155                 160 


Tyr Gln Ile Cys Ile Ser Asn Ser Ser Ser Ser Lys Asp Ser Met Cys 
                165                 170                 175     


Gly Asn Ala Ser Thr Cys Cys His Asp Ile Arg Lys Phe Gln Leu Trp 
            180                 185                 190         


Arg Leu Lys Glu Pro Ala Glu Leu His His Gln Gly Ala Ala Val Gly 
        195                 200                 205             


Asp Gly Asn Leu Ala Asn Asp Leu Ser Ile Val Gln Asp Ala Ala Lys 
    210                 215                 220                 


Ile Gln Leu His His Leu Lys Ala Glu Val Gly Val Asp Arg Pro Lys 
225                 230                 235                 240 


Pro Pro Ser Arg Thr Asp Phe Leu Leu Gln Leu Leu Gly Gln Gln Leu 
                245                 250                 255     


Asp Ala Ser His Gln Pro Ser Val Pro Ser Asp Leu Lys Leu Ala His 
            260                 265                 270         


Asn Val Ser His Val Val Thr Thr Lys Gly Pro Pro Thr Gly Asp Gln 
        275                 280                 285             


Gln Leu Ile Cys Ser Ser Tyr Pro Leu Ala Ala Ala Ser Lys Met Ala 
    290                 295                 300                 


Glu Pro Ser Ser Glu Met Thr Ser Asn Lys Gly Leu Ser Thr Lys Glu 
305                 310                 315                 320 


Pro Lys Ala Ala Asn Ala Thr Met Ala His Lys Gln Lys Arg His Gly 
                325                 330                 335     


His Ser His Pro Ser Arg Cys Arg Asp Ser Phe Thr Thr Tyr Phe Pro 
            340                 345                 350         


Arg Val Leu Lys Gln Val His Ala Gly Leu Ser Leu Ser Pro Glu Ala 
        355                 360                 365             


Val Asp Val Ile Asp Ser Phe Val His Asp Ile Leu Glu His Ile Ala 
    370                 375                 380                 


Thr Lys Ala Gly His Leu Ala His Tyr Thr Lys Cys Thr Thr Ile Thr 
385                 390                 395                 400 


Ser Cys Glu Met Gln Thr Thr Ile Arg Leu Met Phe Pro Gly Gln Met 
                405                 410                 415     


Gly Lys His Ala Ile Ser Arg Gly Ser Lys Thr Leu Leu His Tyr Thr 
            420                 425                 430         


Arg Ser Lys 
        435 


<210>  4182
<211>  1729
<212>  DNA
<213>  Homosapiens

<400>  4182
tgcagggctc tgggcgggaa ggctaacctg gtgcggagcc agcctgggtc tcagccccgc     60

gtacggcctt tcacgagtct tcaagccttc aggctttctt ctagtcaaga tgagtgataa    120

accagacttg tcggaagtgg agaagtttga caggtcaaaa ctgaagaaaa ctaatactga    180

agaaaaaaat actcttccct caaaggaaaa acttcattat gtgcgatatg gcaagagaga    240

aagtgaatac gctgatataa gaagcaagaa accttccttc cttccagatg tgtgtcagta    300

gaattacaga gtgtccacgg aaacagctca tgccctagtg tacagtggtg cagccaatga    360

gtgacctgaa gtctatgagc aacactcatt gtcccaatgt gggacgagtg accgaagctg    420

aacccacaac agccttcctg tgatattcca cgtggtggtt aaaggcatgg cgatgtgatt    480

ctttacctga tgtttttgtt tgcagtgttt gtaatcatgg tcttttaggg atatgaatcc    540

aaagctaaga ttaatatacg ttccttgacc ctaacatcaa gttatacaga gcattgtcag    600

ccattagaag aagtcagata acgcttattt cctcaaaaga ttggcatatt aatattcacg    660

ttaatattaa tacaggctac ctttcattgt gctctcttct gggtcccaag tcttggtatt    720

tttagaattt ttttttttct ataagtgtat tgctgaattt cagagcaggt gctgacttac    780

ccattgcttt ccttttccat tgatttccag tcgcccgagt atgtggacaa gagaacatac    840

tctgggattg caacccacag gaatttatta tgttgtgcct tgaagctcaa tatgtggcca    900

tttttgttaa atgtttcccg taaattttga aacatctcat aaacaaccct tctccttcat    960

atgtagaaac cagtaaagga tggcactctc agtcaaacca cgaagcaaaa gctggataaa   1020

tgacaaaaat caaaattttc ttgagcccgt cagaagtggg aaagaaccac cccagaggga   1080

cccaacacat agccacatag attatttcac catttaaaga ggaccccttg gtcaagaggg   1140

aaaagggttc ggggcaggat agtagccaga gcttccctga gtagtgcaga tgggaagagg   1200

ggaaggtcac ctccagagct ccacttggga tccatagaga aatgatatag aaccaagaag   1260

tccactcact gggatttgtt actttctgtt tttccagaat attagaaaaa tattatgaaa   1320

atagttgaag agaaatgtta tgaaaatagt tgaaggagac caagaaaaac tcccacaaaa   1380

tcagctgcaa gtaaatccct ctggatggtg ccgccacatg ttcctacaag tccagaacaa   1440

cccttgccaa accaaagaca cttggcagaa ccctgttcct ttctagagac agagctgtat   1500

acctgttcca aaacaccaca tctcactcag tgacttattt ctcattatgc taattgtttt   1560

gctgtaaagt gccaatgttt ctgtgaatta agacatacga ataaatttct gaagttaaaa   1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa               1729


<210>  4183
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  4183

Met Ser Asp Lys Pro Asp Leu Ser Glu Val Glu Lys Phe Asp Arg Ser 
1               5                   10                  15      


Lys Leu Lys Lys Thr Asn Thr Glu Glu Lys Asn Thr Leu Pro Ser Lys 
            20                  25                  30          


Glu Lys Leu His Tyr Val Arg Tyr Gly Lys Arg Glu Ser Glu Tyr Ala 
        35                  40                  45              


Asp Ile Arg Ser Lys Lys Pro Ser Phe Leu Pro Asp Val Cys Gln 
    50                  55                  60              


<210>  4184
<211>  935
<212>  DNA
<213>  Homosapiens

<400>  4184
gaagctggcc cgagatgtgg agccatgctg cgtaccgaag tgccccggct tccccggtcc     60

acaaccgcca ttgtctggtc gtgccatcta atggccactg cctccgccat ggctggacct    120

tcctctgaga cgacctctga ggaacagctg atcacccagg agcccaaaga ggccaactcc    180

actacgtccc agaagcagag caagcagagg aagcgagggc gccatgggcc ccgcaggtgc    240

cactccaact gccgcgggga cagcttcgcc acctatttcc gccgggtgct gaagcaggtt    300

caccagggcc tcagcctttc ccgggaggcc gtgagtgtca tggattcttt ggttcatgac    360

atattggacc gcatcgccac cgaggctggt cacctggccc gctccaccaa gcgccagacc    420

atcactgcct gggagacccg gatggctgtg cgcctgctgc tgccggggca gatgggcaag    480

ctcgccgagt ccgaaggcac gaaggctgtc ctcagaactt cactgtatgc catacagcaa    540

cagagaaagt gaatacgctg atacaagaag caagaatatt agaaaaatgt catgaaaata    600

gttgaagaga aatgctcact gcacaaggag accaagaaaa accccccacg aaatcagcca    660

caactaaatc gctctggacg gtgccgccag gtgaccctac atgtccggag caacactttg    720

aaaaccaaag acgcttggca gaaccctgtt cctttccaga gacagagctg tgtaccttgt    780

ctaaaacacc gcatctcact cagtgactta tttctcatta tgctaattgt tttcgcttta    840

aagcgccagt ctttctgtca aatgggacat acaaataaat ttctaaaatt aaaaaaaaaa    900

aaaaaaaaaa aaaaaaaaag aaaaaaaaaa aaaaa                               935


<210>  4185
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  4185

Met Leu Arg Thr Glu Val Pro Arg Leu Pro Arg Ser Thr Thr Ala Ile 
1               5                   10                  15      


Val Trp Ser Cys His Leu Met Ala Thr Ala Ser Ala Met Ala Gly Pro 
            20                  25                  30          


Ser Ser Glu Thr Thr Ser Glu Glu Gln Leu Ile Thr Gln Glu Pro Lys 
        35                  40                  45              


Glu Ala Asn Ser Thr Thr Ser Gln Lys Gln Ser Lys Gln Arg Lys Arg 
    50                  55                  60                  


Gly Arg His Gly Pro Arg Arg Cys His Ser Asn Cys Arg Gly Asp Ser 
65                  70                  75                  80  


Phe Ala Thr Tyr Phe Arg Arg Val Leu Lys Gln Val His Gln Gly Leu 
                85                  90                  95      


Ser Leu Ser Arg Glu Ala Val Ser Val Met Asp Ser Leu Val His Asp 
            100                 105                 110         


Ile Leu Asp Arg Ile Ala Thr Glu Ala Gly His Leu Ala Arg Ser Thr 
        115                 120                 125             


Lys Arg Gln Thr Ile Thr Ala Trp Glu Thr Arg Met Ala Val Arg Leu 
    130                 135                 140                 


Leu Leu Pro Gly Gln Met Gly Lys Leu Ala Glu Ser Glu Gly Thr Lys 
145                 150                 155                 160 


Ala Val Leu Arg Thr Ser Leu Tyr Ala Ile Gln Gln Gln Arg Lys 
                165                 170                 175 


<210>  4186
<211>  2157
<212>  DNA
<213>  Homosapiens

<400>  4186
atgaagtgtc acgcagggag cctctcagca aacctacctg cgttgaaggt gactggatgg     60

tcccgttgcg tggcatctcg tcaaccaatc acagtgggcg tctgcgggcc taagcgcccc    120

ttgtggccca gctcggagaa accattcaac tttcatactt tggcgaagct ccatgacata    180

ggcctgggca atgatttttt ggatatgacc ctgaaagccc agcaacagaa gcaaaaaagc    240

catgcgacca taccaaagtg ccccccactt ccctggtccc caaccgtcac tctctgttct    300

tgctatctaa tggccgctgc ttccgccatg gctgaggctt cctctgagac aacctcggag    360

gaaggccaga gcatccagga gcccaaagag gccaactcca cgaaggccca gaagcagaag    420

aggcgagggt gccgaggctc ccgcaggcgc cacgccaacc gccgtgggga cagcttcggg    480

gacagcttca ccccctattt cccccgggtg ctgaagcagg ttcaccaggg cctcagcctt    540

tcccaggagg ccgtgagtgt catggattct atgatccatg acatattgga ccgcatcgcc    600

accgaggctg gtcagctggc ccattacacc aagcgcgtga ccatcacctc ccgggacatc    660

cagatggccg tgcgactgct gctgccgggg aagatgggca agctcgccga ggcccagggc    720

acgaatgccg ccctcagaac ttcattatgt gcgatatggc aacagagaaa gtgaatatgc    780

tgatacaaga agcaagaaac cttccttact tccaggtgtg tgtcagtagg attacggagt    840

gtccacggaa acagctcatg ccctagtgta cagtggtaca gccaatgagt gacctgcagt    900

ctatgagcaa cagtcattga cccaatgtgg ggggagtgac ccaagctgaa cccacagcag    960

ccttcctgtt atattcaacc tggtgtttaa aggaacggca gtgtgattct ttacctgatg   1020

tttttgtttg cattgcttgt aatcatgatc ttttagggat atgaatccaa agctaagatt   1080

agaatatgta ccttgtccct aacatcaagt tatacagaac attggcaacc attagtagaa   1140

gtcagataag gcttatttcc tcaaaagatt agcatattta tattcatgtt aatattaata   1200

taggctacct ttcattgtgc tctcttctgg gtcccaagtc ttggcatttt aagcattttt   1260

ttctataagt gtattgctga atttcagagc aggtgctcac tttcccattg ctttcctttt   1320

ccattgattt ccagtcgccc gagtatgtgg acaagagaac atactctggg actgcaaccc   1380

acaggaattt attatgttgt gccttgaagc tcaacatgtg gccatttttg ttaaatgttt   1440

cccgtaaatt ttgaaacatc tcataaacaa cccttctcct tcatatgtag aaaccagtaa   1500

aggatggcac tctcagtcaa accatgaaac aaaagctgga taaatgacaa aaatcaaaat   1560

tttcttgagc ccatcagaag tgggaaagaa ccaccccaga gggcccaaca catagccaca   1620

tagattattc caccatttaa agaggacccc ttggtcaaga gggaaacagg gtcagggcaa   1680

gatggtagcc agagcttccc tgagtagtgc agatgggaag aggggaaggt cacctccaga   1740

gctccacttg ggatccatag agaaatgata tagaaccaag aagtccactc attgggatct   1800

gttactttct gtttttccag attattagaa aaatattaca gaaatagctg aagagaaatg   1860

ttatgaaaat agttgaagtt gtgcttattg cacgaggaga ccaagaaaaa ccccacaaaa   1920

tcagctgcaa gtaaatcctt ctggatggtg ccaccaaatg ttcctacaag tccggaacaa   1980

cccttgccaa accaaagacc cttgccagaa ccctgcttct tcccagagac agagctgtgt   2040

acctgacaaa acaccacatc tcactcagtg acttatttct cattatgcta attgttttgc   2100

tgtaaaatgc caatgtttct gtgaattaag acatacgaat aaatttctga agttacc      2157


<210>  4187
<211>  257
<212>  PRT
<213>  Homosapiens

<400>  4187

Met Lys Cys His Ala Gly Ser Leu Ser Ala Asn Leu Pro Ala Leu Lys 
1               5                   10                  15      


Val Thr Gly Trp Ser Arg Cys Val Ala Ser Arg Gln Pro Ile Thr Val 
            20                  25                  30          


Gly Val Cys Gly Pro Lys Arg Pro Leu Trp Pro Ser Ser Glu Lys Pro 
        35                  40                  45              


Phe Asn Phe His Thr Leu Ala Lys Leu His Asp Ile Gly Leu Gly Asn 
    50                  55                  60                  


Asp Phe Leu Asp Met Thr Leu Lys Ala Gln Gln Gln Lys Gln Lys Ser 
65                  70                  75                  80  


His Ala Thr Ile Pro Lys Cys Pro Pro Leu Pro Trp Ser Pro Thr Val 
                85                  90                  95      


Thr Leu Cys Ser Cys Tyr Leu Met Ala Ala Ala Ser Ala Met Ala Glu 
            100                 105                 110         


Ala Ser Ser Glu Thr Thr Ser Glu Glu Gly Gln Ser Ile Gln Glu Pro 
        115                 120                 125             


Lys Glu Ala Asn Ser Thr Lys Ala Gln Lys Gln Lys Arg Arg Gly Cys 
    130                 135                 140                 


Arg Gly Ser Arg Arg Arg His Ala Asn Arg Arg Gly Asp Ser Phe Gly 
145                 150                 155                 160 


Asp Ser Phe Thr Pro Tyr Phe Pro Arg Val Leu Lys Gln Val His Gln 
                165                 170                 175     


Gly Leu Ser Leu Ser Gln Glu Ala Val Ser Val Met Asp Ser Met Ile 
            180                 185                 190         


His Asp Ile Leu Asp Arg Ile Ala Thr Glu Ala Gly Gln Leu Ala His 
        195                 200                 205             


Tyr Thr Lys Arg Val Thr Ile Thr Ser Arg Asp Ile Gln Met Ala Val 
    210                 215                 220                 


Arg Leu Leu Leu Pro Gly Lys Met Gly Lys Leu Ala Glu Ala Gln Gly 
225                 230                 235                 240 


Thr Asn Ala Ala Leu Arg Thr Ser Leu Cys Ala Ile Trp Gln Gln Arg 
                245                 250                 255     


Lys 
    


<210>  4188
<211>  6241
<212>  DNA
<213>  Homosapiens

<400>  4188
gggaagcaaa gaggattgtg ggagctccgt tgtgcgtcgc ttaagtgagg gcggcggatg     60

ggcgaaggtc cggtgactgc gactgtcgct gctttctgag gccacaggaa aggggccgtc    120

ggtcgccgcc atgacagcga gcgaggcgga gtttcttcca tctgcaccca gttgtcttca    180

gcatggggga gcagaaccac tctcccggga aggagcttca gcacaggacg cgagcagagg    240

ctccaggaaa gaaaagctgg cattcccagg cctatgccct tggggccgtt tccaacttta    300

tgtctacttt tctgaccttt cctatctata aggttgtgtt ccggcaacag atccatgcca    360

tggcagtgtc agaggctgtg agacagcttt ggcatgaagg tcctcaatac ttctaccggg    420

gaatctaccc tcctcttctc tccaagacgt tgcaagggac tcttctgttt gggacttatg    480

atagcctgct gtgctttctc tctcctgttg ggccacacac cctgggacac cgctgggctg    540

ccgggctcat gtctggcgtg gtggaggccg tggcactcag cccctttgaa agggtgcaaa    600

atgtgctcca ggatggtcgc aagcaagctc gcttccccag caccttctgc attctcaagg    660

aattcaattc ttatgggctt tgggggcggc tgtcactggg ctactatcgt ggtttctggc    720

ctgtcctggc caggaacagc ctggggagtg ctctatattt ttctttcaag gaccccatcc    780

aggatggcct ggcagagcaa ggcctgcccc actgggttcc tgccttggtg tctggtagtg    840

tcaatggaac aatcacctgc ctagttctgt atcctctgat tgtgctggtt gctaatatgc    900

agtcccatat tggatggcag aacatgccaa gcctgtgggc ctctgcccag gatgtatgga    960

acactcgggg ccgaaagctg ctcctgatct accgtggagg ctccctagtc atcctaaggt   1020

ccagtgtgac atggggcctc actacggcaa tccatgactt cctgcagagg aagtcgcact   1080

ccaggaaaga gctgaagact gactagctgc agaaagtgtg gcatggcagc tttgttattc   1140

taaatcttcc ctggttggtt ctatatagct tacttctttg gctaggttgc ctaatacagc   1200

catcctttag catctataaa ctcattgcat gggagaagtt cccaactacc aacctgttga   1260

gcaaggacaa agcccaaaag tattccttag tcaaaaagaa acgttcaccc cagtctctcc   1320

acagtttcag tagcctcaga gccaggaggc ctttaaataa catgtaaccc agattaagtg   1380

tcattccttt aaggaattcc ttggcaataa acagaaactt aaaaagatga ccttacttag   1440

gcactctgag ctctgggacc cctctaggtg tcctccagac caaactgagt ggaactccaa   1500

tttcaaagaa ctatgcttga ctcttaggat gggaattcca taaaacttct cagatggcta   1560

cattttcatg atattgttca ctgcctctac caccacctct cacttctcaa ggctgtgggt   1620

cctactttca gggtagcagc tgtggctgga aatcctaaat taggcttgca tgaactcgtc   1680

aggtgccaca agaactagtg gggctggaga tgggagtgag aagaggcgtg gcccatggat   1740

ggaaagaata aaaactttga aagaaaagat ttaattacat gcaaaataga aacatttgct   1800

atagtctgct tggtgttatc tgctaggaca tttccgagag caaggtgata acattgccta   1860

gaaaccgttt gagtttccct aagaaacctg gaaatgaagt gaccatatct cttcacagaa   1920

aattgcatat tttgttgatg tggttaaatg tagttactat gacataaaga tcagaaatct   1980

tagcctgtca ttcagagcca ttcaaaatat ggtcatcata taactttcaa catattgtca   2040

ctccacttac ataaacccca aacactagcc ataatgaact attgttctct ccccagacat   2100

tccatgaact ttcccatggc catactctgg cccacactat tctttccacc tgcagtgctc   2160

cttcttcaca tgccagtcta ccaaaatcct tccagttcct tgaagcccag ctcagaggtc   2220

accttctcta tggagttctt gattttcccc tactgaatgt gacattagtc tctgtgatgc   2280

ccctttcttt tttttttttt tgagacggag tttcgctctt gttgcccagg ctggagtgcc   2340

aatggtgtga tctcagctca ctgcaacctc cacctcccgg attcaagtga ttctcctgcc   2400

tcagcctccc gagtagctgg aattacaggc gcccaccacc atgcctggct aattttgtat   2460

ttttagtaga gatggggtct ctccatgttg gtcaggctgg tctcgaactc ccaacctcat   2520

caggtgatcc acccacctcg gtctcccaaa gtgctgggat tacaggcgtg agccaccgcg   2580

cccagcctct gtgatgcccc tttctaacag cacttcatac agggtactga ttccattatg   2640

tcactaatct catgtgaccc tttgttcttg tattcttcaa tacctcctac tagactgtaa   2700

aactcattga aagcagggat ttttgtatgc attttaaaat cttccattgt gcctaggtgc   2760

tcaataacgt tggtcaaatt actgagttga ttatcaagct gtgatatggt atatcctcag   2820

ggtgctgtcc cttgtacatg acgataaagt tattgactca ctgtcagcaa gacacgtgcc   2880

tttgggctgt gtttttgctt tcttttaata attgatttag ttttgtgcta atgataatga   2940

tgctgctact gataataata ataacaataa taaaaattac tttcaactgg cacatttgat   3000

gagtttatat tactgatggc atgtttgcta ttagcaccag ttcaggaact gaaatttcac   3060

aaacagaatc acactgtaca actgtaccat ttgtttcaac tctggaattt tgaggatttc   3120

caagatgaca tgtgttatag tttcccccta cagatatctt agtaatgccc tcctcttgca   3180

tctccttact gaaccaaatt tgtcctgtat ttgtcttact tggttgtaga tttagcagtg   3240

agaacttctc actgaatgcc acagaaatta aagacatggt tgttggaggt atgatgtcag   3300

agagcatttg ccaccaaggt tggcagaaaa tggctggtcc aggagagctg aagatgagct   3360

tccacatctg cagatcggga tgtgttggga cagtactcaa cttgtggatt caaggaagta   3420

tgaacacaga gtctgcataa ggaaaggaaa aagatgcatt catctcccaa gtacaccggt   3480

gatttccact tatgtcattc tgtccatcca tgtccctttc ttcattttaa cttcttattt   3540

aaaaataatt tcaaacattt aaaaatgttg caagcataaa taaagcttaa agaacaccca   3600

tgtccccttt accctaattc ccctattatt aatgtttctc cccatttgct ttattattta   3660

agtgtgcact ctgtctatac acacacagga tattttttcc ctgaactatc tgagagttgc   3720

atacatcagt tttcaatatt cctagattca atgtttgtag atccaaatta ttttttaaga   3780

gaccgtgttt tatctctgac aatgggacag ttattacaga atataataaa atgaaaactc   3840

acacaatata tgtgatattg tgaaatatat acttggtctt tgatcctgtt tcttggcata   3900

caactcctaa aatccttaga atttccaaag tgatatcttt ttgtatgcta ataattgact   3960

gatggctggc agcctctggt tgcttcagga tgggaactag tcaccaggaa gaccaaggca   4020

ccattagagg gttgggactt aacagcctca ttcccgacct ccagggaggg gagagggatg   4080

gaaggttaag ttgatcacca gtggccaatg atttaatcaa tcatgcctac gcaatgaagc   4140

ttccataaaa accccaaagc actgggtttg gagagcttcc agatagctga acatgtggag   4200

gttcctggag ggtggtgacc cagggagggc acagaagctc tgagcccctt ccgcagtacc   4260

tcaccctatg catctcttca tctctatcct ttgatatatc ctttataata aagtggtaaa   4320

cgttaagtat ttccccaagt tctgtgaccc tttctggcaa attaaaccca aagaaggggt   4380

catgtgaact caaacttgaa gcccatctgt cagaagttct ggaggcttgg atttgcgact   4440

ggtgtctgaa gggcctggga acagtcttgt gaaacctagt cctcagcttg tgggatatga   4500

cgctatctcc aggtagattg tgtcagaatg gaattggagt acacccagct ggtgttcgct   4560

gcagaactga ttgctcactt agtgtgtggg aaaactccac acatctggac atggaaatat   4620

tctgtgctga ttgccgtggt gtaagagcaa tgcaaaaagt ttgggtattt tcccctcgga   4680

gtatattttg aagctaaatt gctaataatt gcttaaattt actatatttg cctttataaa   4740

aactttatgt atgttgaagc ttgaagctat gcaattataa tataaacatg gatttacaac   4800

taaagcatgt tataatttaa ataattgagt ttttcaaatc ggttcatatg aaatcctagg   4860

caatattgta aaattataca gacctgtcaa ctttttccac ttaaaagttg tgagcaaaat   4920

ttaagggcat agtcgttttc aagtaatttt aaatgtcaat gttaatattt agtttagtga   4980

tgttaatgga gctatgtttt ctgatattaa aaatgagttt taggagttga gaccaataaa   5040

ataaggaggt aataaatatc tatatctgtt taaacacata aaatatacaa tttaacacta   5100

aaattacttg gtataaaaag tcaaaaaaag gaataaaaag ccatcataca acacaatata   5160

tgcgtgatat atatttttct ctaaatataa actacatcag cttttataaa gctcaagttg   5220

aaataataac gttttatgac aaatcattat atggtatatt ctgacttaat tttgcattta   5280

caatttattt ttaaacacta aatagcatta taattttact gggataacta tatatagtgt   5340

agtatattaa agttaataaa atgacgttgc atatgagaga aaaagcataa taaatcagaa   5400

acaatataaa aagctttcag aaaagataaa aatattgtat ttctctagtc tgttcactct   5460

ccagtgtctc tggttctttc atatcatctt cctttcctca aatcttttaa tactccctcc   5520

ctcatcattt ccaactagtg accctacttt ctatttcatt aagaaaacag atacattcag   5580

aagagaactg ccagtttaaa gaacatttac aaagccatca cccatgtaat aaccagccag   5640

agcaagaaat agagcccttt aataacctac tcttctcccc ccaccactga tgacaccgct   5700

ccctccatct taggtgtagc ccccatgctg acttttgtaa taataatttc tttgcttttg   5760

tttataagtt ttcttcctta taagcatctc taaacaacag ttttgtttta cagatgttca   5820

aacattaaat gctttttaga cttggaattg tgactatctt gtttcactcc acattgcttg   5880

tgagactcat tgatattgca gatagctgta gttgatccat ttttattgtt gtacagttta   5940

ccattgtata aatataccat gatttattca tgataacttt gaggaacatt ctggttgttt   6000

gcaggtttta tttttacagt tcattagttt tattgatgta taataattgt atatgtttat   6060

ggggtatatg tgatattttg atacatgtgt acaatgtgta atgattaaat caaggtaatt   6120

gggatatcca tcagctcaaa catttatcat ttctttgcat tgggaacatt ccaaatcttc   6180

tcttctagct attttgaaat acacaataaa ttgaatactg tggtcaaaaa aaaaaaaaaa   6240

a                                                                   6241


<210>  4189
<211>  307
<212>  PRT
<213>  Homosapiens

<400>  4189

Met Gly Glu Gln Asn His Ser Pro Gly Lys Glu Leu Gln His Arg Thr 
1               5                   10                  15      


Arg Ala Glu Ala Pro Gly Lys Lys Ser Trp His Ser Gln Ala Tyr Ala 
            20                  25                  30          


Leu Gly Ala Val Ser Asn Phe Met Ser Thr Phe Leu Thr Phe Pro Ile 
        35                  40                  45              


Tyr Lys Val Val Phe Arg Gln Gln Ile His Ala Met Ala Val Ser Glu 
    50                  55                  60                  


Ala Val Arg Gln Leu Trp His Glu Gly Pro Gln Tyr Phe Tyr Arg Gly 
65                  70                  75                  80  


Ile Tyr Pro Pro Leu Leu Ser Lys Thr Leu Gln Gly Thr Leu Leu Phe 
                85                  90                  95      


Gly Thr Tyr Asp Ser Leu Leu Cys Phe Leu Ser Pro Val Gly Pro His 
            100                 105                 110         


Thr Leu Gly His Arg Trp Ala Ala Gly Leu Met Ser Gly Val Val Glu 
        115                 120                 125             


Ala Val Ala Leu Ser Pro Phe Glu Arg Val Gln Asn Val Leu Gln Asp 
    130                 135                 140                 


Gly Arg Lys Gln Ala Arg Phe Pro Ser Thr Phe Cys Ile Leu Lys Glu 
145                 150                 155                 160 


Phe Asn Ser Tyr Gly Leu Trp Gly Arg Leu Ser Leu Gly Tyr Tyr Arg 
                165                 170                 175     


Gly Phe Trp Pro Val Leu Ala Arg Asn Ser Leu Gly Ser Ala Leu Tyr 
            180                 185                 190         


Phe Ser Phe Lys Asp Pro Ile Gln Asp Gly Leu Ala Glu Gln Gly Leu 
        195                 200                 205             


Pro His Trp Val Pro Ala Leu Val Ser Gly Ser Val Asn Gly Thr Ile 
    210                 215                 220                 


Thr Cys Leu Val Leu Tyr Pro Leu Ile Val Leu Val Ala Asn Met Gln 
225                 230                 235                 240 


Ser His Ile Gly Trp Gln Asn Met Pro Ser Leu Trp Ala Ser Ala Gln 
                245                 250                 255     


Asp Val Trp Asn Thr Arg Gly Arg Lys Leu Leu Leu Ile Tyr Arg Gly 
            260                 265                 270         


Gly Ser Leu Val Ile Leu Arg Ser Ser Val Thr Trp Gly Leu Thr Thr 
        275                 280                 285             


Ala Ile His Asp Phe Leu Gln Arg Lys Ser His Ser Arg Lys Glu Leu 
    290                 295                 300                 


Lys Thr Asp 
305         


<210>  4190
<211>  2985
<212>  DNA
<213>  Homosapiens

<400>  4190
gtgaggcgag cctggagctc atttccaggc gcccttccct cttcggaact aagggagact     60

tgtgggcttt tgcacactgg ctgtagggtt cccgggaaag actggagcag cgaacaggag    120

ggagagaggt ggacaggcag agtctgcacc tgccgcctgc acctccgtta gggcgacagg    180

gcagctggtg tttcgctcct ggagtgtgcc tacctcgcaa ggggggcgag ggccacaggc    240

tgaggcgccc gcgtcccgga gtgcaccgct tggccgaggc aaggtgttgc tggggcaagg    300

ctgctccgaa gcgaagtcgc gcaaaaggaa gagtctggga ggcaggcgac ttaggagagt    360

ctagtcactg agagacagag gcagcatctg ccattctaac tacggagctg agtaatttag    420

aaaccctcct taactctccc tttccagctc tccccaaagt ccacagaagc tctgctgaac    480

tctagaaatc ttccctggct ggggggaagt ttactagtat cctctttggc taagacaggg    540

agtggaaaaa acaggcgggg ctgtactgtc cgctgtttgg ggagacgcgg tcttcctcgc    600

gcccccttca gccactccga ctgcctggga agtcccagcc cgcgctctcc ggaacccggc    660

tcgccgtctc gccctggaca tggaactacg catctgagac ctgctggacg ttttgctggc    720

cgttttgcaa gactcagctg tcaagaaaag tgaaggatga agccaccatt tcttttggcc    780

cttgtggtct gttctgtagt cagcacaaat ctgaagatgg tgtcaaagag aaattctgtg    840

gatggctgca ttgactggtc agtggatctc aagacataca tggctttggc aggtgaacca    900

gtccgagtga aatgtgccct tttctacagt tatattcgta ccaactatag cacggcccag    960

agcactgggc tcaggcttat gtggtacaaa aacaaaggtg atttggaaga gcccatcatc   1020

ttttcagagg tcaggatgag caaagaggaa gattcaatat ggtttcactc agctgaggca   1080

caagacagtg gattctacac ttgtgtttta agaaactcaa catattgcat gaaggtgtca   1140

atgtccttga ctgttgcaga gaatgaatca ggcctgtgct acaacagcag gatccgctat   1200

ttagaaaaat ctgaagtcac taaaagaaag gagatctcct gtccagacat ggatgacttt   1260

aaaaagtccg atcaggagcc tgatgttgtg tggtataagg aatgcaagcc aaaaatgtgg   1320

agaagcataa taatacagaa aggaaatgct cttctgatcc aagaagttca agaagaagat   1380

ggaggaaatt acacatgtga acttaaatat gaaggaaaac ttgtaagacg aacaactgaa   1440

ttgaaagtta cagctttact cacagacaag cctcccaagc cattgttccc catggagaat   1500

cagccaagtg ttatagatgt ccagctgggt aagcctctga acatcccctg caaagcattc   1560

ttcggattca gtggagagtc tgggccaatg atctactgga tgaaaggaga aaagtttatt   1620

gaagaactgg caggtcacat tagagaaggt gaaataaggc ttctcaaaga gcatcttgga   1680

gaaaaagaag ttgaattggc actcatcttt gactcagttg tggaagctga cctggcgaat   1740

tatacctgcc atgttgaaaa ccgaaatgga cggaaacatg ccagtgtttt gctgcgtaaa   1800

aaggatttaa tctataaaat tgagcttgca gggggcctgg gagcaatctt cctcctcctt   1860

gtactgctgg tggtcattta caaatgctac aacattgaat tgatgctctt ctacaggcag   1920

cactttggag ctgatgaaac taatgatgac aacaaggaat atgatgccta tctctcttac   1980

acaaaagtgg accaagatac tttagactgt gacaatcctg aagaagagca gtttgctctt   2040

gaagtactgc cagatgtcct ggaaaaacac tatggatata aactcttcat cccagaaaga   2100

gacctgattc caagtggaac atacatggaa gatctcacaa gatatgttga acaaagcaga   2160

agacttatta tcgtgctaac tccagactat attctcagac ggggatggag tattttcgaa   2220

ctggaaagca gactccataa catgctagtc agtggagaaa tcaaagtgat tttgattgag   2280

tgtacagaat taaaagggaa agtgaattgc caggaagtgg aatcactaaa gcgtagcatc   2340

aaacttctgt ccctgatcaa gtggaaggga tccaaaagca gcaaattaaa ttctaagttt   2400

tggaagcact tagtatatga aatgcccatc aagaaaaaag aaatgctacc tcggtgccat   2460

gttctggact ccgcagaaca aggacttttt ggagaactcc agcctatacc ctctattgcc   2520

atgaccagta cttcagccac tctggtgtca tctcaggctg atctccctga attccaccct   2580

tcagattcaa tgcaaatcag gcactgttgc agaggttata aacatgagat accagccacg   2640

accttgccag taccttcctt aggcaaccac catacttatt gtaacctgcc tctgacgcta   2700

ctcaacggac agctacccct taataacacc ctgaaagata cccaggaatt tcacaggaac   2760

agttctttgc tgcctttatc ctccaaagag cttagcttta ccagtgatat ttggtagtga   2820

aaaatctgaa ttcctctgaa cagctagata agcatagaga atttctgtta taccaagcat   2880

aaagtacacc taataacgtt gtgttaaaaa agtgtttgaa gaaaaaggta caaaaatggc   2940

ttttatactt aaatattttt gtttacattt ccagaatagt ggggg                   2985


<210>  4191
<211>  686
<212>  PRT
<213>  Homosapiens

<400>  4191

Met Lys Pro Pro Phe Leu Leu Ala Leu Val Val Cys Ser Val Val Ser 
1               5                   10                  15      


Thr Asn Leu Lys Met Val Ser Lys Arg Asn Ser Val Asp Gly Cys Ile 
            20                  25                  30          


Asp Trp Ser Val Asp Leu Lys Thr Tyr Met Ala Leu Ala Gly Glu Pro 
        35                  40                  45              


Val Arg Val Lys Cys Ala Leu Phe Tyr Ser Tyr Ile Arg Thr Asn Tyr 
    50                  55                  60                  


Ser Thr Ala Gln Ser Thr Gly Leu Arg Leu Met Trp Tyr Lys Asn Lys 
65                  70                  75                  80  


Gly Asp Leu Glu Glu Pro Ile Ile Phe Ser Glu Val Arg Met Ser Lys 
                85                  90                  95      


Glu Glu Asp Ser Ile Trp Phe His Ser Ala Glu Ala Gln Asp Ser Gly 
            100                 105                 110         


Phe Tyr Thr Cys Val Leu Arg Asn Ser Thr Tyr Cys Met Lys Val Ser 
        115                 120                 125             


Met Ser Leu Thr Val Ala Glu Asn Glu Ser Gly Leu Cys Tyr Asn Ser 
    130                 135                 140                 


Arg Ile Arg Tyr Leu Glu Lys Ser Glu Val Thr Lys Arg Lys Glu Ile 
145                 150                 155                 160 


Ser Cys Pro Asp Met Asp Asp Phe Lys Lys Ser Asp Gln Glu Pro Asp 
                165                 170                 175     


Val Val Trp Tyr Lys Glu Cys Lys Pro Lys Met Trp Arg Ser Ile Ile 
            180                 185                 190         


Ile Gln Lys Gly Asn Ala Leu Leu Ile Gln Glu Val Gln Glu Glu Asp 
        195                 200                 205             


Gly Gly Asn Tyr Thr Cys Glu Leu Lys Tyr Glu Gly Lys Leu Val Arg 
    210                 215                 220                 


Arg Thr Thr Glu Leu Lys Val Thr Ala Leu Leu Thr Asp Lys Pro Pro 
225                 230                 235                 240 


Lys Pro Leu Phe Pro Met Glu Asn Gln Pro Ser Val Ile Asp Val Gln 
                245                 250                 255     


Leu Gly Lys Pro Leu Asn Ile Pro Cys Lys Ala Phe Phe Gly Phe Ser 
            260                 265                 270         


Gly Glu Ser Gly Pro Met Ile Tyr Trp Met Lys Gly Glu Lys Phe Ile 
        275                 280                 285             


Glu Glu Leu Ala Gly His Ile Arg Glu Gly Glu Ile Arg Leu Leu Lys 
    290                 295                 300                 


Glu His Leu Gly Glu Lys Glu Val Glu Leu Ala Leu Ile Phe Asp Ser 
305                 310                 315                 320 


Val Val Glu Ala Asp Leu Ala Asn Tyr Thr Cys His Val Glu Asn Arg 
                325                 330                 335     


Asn Gly Arg Lys His Ala Ser Val Leu Leu Arg Lys Lys Asp Leu Ile 
            340                 345                 350         


Tyr Lys Ile Glu Leu Ala Gly Gly Leu Gly Ala Ile Phe Leu Leu Leu 
        355                 360                 365             


Val Leu Leu Val Val Ile Tyr Lys Cys Tyr Asn Ile Glu Leu Met Leu 
    370                 375                 380                 


Phe Tyr Arg Gln His Phe Gly Ala Asp Glu Thr Asn Asp Asp Asn Lys 
385                 390                 395                 400 


Glu Tyr Asp Ala Tyr Leu Ser Tyr Thr Lys Val Asp Gln Asp Thr Leu 
                405                 410                 415     


Asp Cys Asp Asn Pro Glu Glu Glu Gln Phe Ala Leu Glu Val Leu Pro 
            420                 425                 430         


Asp Val Leu Glu Lys His Tyr Gly Tyr Lys Leu Phe Ile Pro Glu Arg 
        435                 440                 445             


Asp Leu Ile Pro Ser Gly Thr Tyr Met Glu Asp Leu Thr Arg Tyr Val 
    450                 455                 460                 


Glu Gln Ser Arg Arg Leu Ile Ile Val Leu Thr Pro Asp Tyr Ile Leu 
465                 470                 475                 480 


Arg Arg Gly Trp Ser Ile Phe Glu Leu Glu Ser Arg Leu His Asn Met 
                485                 490                 495     


Leu Val Ser Gly Glu Ile Lys Val Ile Leu Ile Glu Cys Thr Glu Leu 
            500                 505                 510         


Lys Gly Lys Val Asn Cys Gln Glu Val Glu Ser Leu Lys Arg Ser Ile 
        515                 520                 525             


Lys Leu Leu Ser Leu Ile Lys Trp Lys Gly Ser Lys Ser Ser Lys Leu 
    530                 535                 540                 


Asn Ser Lys Phe Trp Lys His Leu Val Tyr Glu Met Pro Ile Lys Lys 
545                 550                 555                 560 


Lys Glu Met Leu Pro Arg Cys His Val Leu Asp Ser Ala Glu Gln Gly 
                565                 570                 575     


Leu Phe Gly Glu Leu Gln Pro Ile Pro Ser Ile Ala Met Thr Ser Thr 
            580                 585                 590         


Ser Ala Thr Leu Val Ser Ser Gln Ala Asp Leu Pro Glu Phe His Pro 
        595                 600                 605             


Ser Asp Ser Met Gln Ile Arg His Cys Cys Arg Gly Tyr Lys His Glu 
    610                 615                 620                 


Ile Pro Ala Thr Thr Leu Pro Val Pro Ser Leu Gly Asn His His Thr 
625                 630                 635                 640 


Tyr Cys Asn Leu Pro Leu Thr Leu Leu Asn Gly Gln Leu Pro Leu Asn 
                645                 650                 655     


Asn Thr Leu Lys Asp Thr Gln Glu Phe His Arg Asn Ser Ser Leu Leu 
            660                 665                 670         


Pro Leu Ser Ser Lys Glu Leu Ser Phe Thr Ser Asp Ile Trp 
        675                 680                 685     


<210>  4192
<211>  1390
<212>  DNA
<213>  Homosapiens

<400>  4192
gggagagaga tcttcctctc tcttcgggcg tgttaagaca gcggggttgg cctgtacttc     60

ctctggccct ggctgaagag ggctagtgaa accgttaaac ccctaggcga tcatggcctt    120

gagacctgag gaccccagta gcgggttccg gcatagcaac gtggtggcct tcatcaacga    180

gaaaatggcc aggcacacga aaggccccga gttctatctt gagaatatat ccttatcctg    240

ggagaaggtg gaagacaagc tgagggccat actggaggac agcgaggtgc ccagtgaggt    300

caaagaggcc tgcacctggg gcagcctggc cttgggtgtg cgctttgccc acaggcaggc    360

acagctacaa aggcacaggg tgcggtggct gcacggcttc gccaaactgc acaaatcagc    420

cgcacaggcc ttggcatcag acctgaagaa gctcagggag cagcaggaga cggaacgcaa    480

ggaggcggcc tcccggctaa gaatggccca gaccagcctc gtggaggtgc agaaagagag    540

agacaaggag ctggtgtctc cccatgagtg ggagcagggg gcagggtggc caggcctggc    600

cactgccgga ggggtttgca cagaaggagc agctgaggag gaagaagagg cggcggtggc    660

tgctgctggt gctgctggag gaaaaggagc agaagaagag cagagggatg tggaggttgt    720

ggctgcccct gtggaggcca tggctccccc tgtggaggct ggggctgccc ccatggagac    780

ccagttcccc cacgtggagg ccagggctgc ctccatggag accacagaga agctggagag    840

aatcctcctg cagctccttg gagatgctga tcaggaaaag tacacctatt gggggcagaa    900

ggagggagat ctccggtcgg tcgaaacagc cacatcttat ttctctggaa ccacgaaccc    960

ctggtccaga gcctcatcag aacctcttcc tgtccagctc cctgcctcat actcatactc   1020

atactcaagc cctttttcct ccttctcaga catacccact atatcccctc cacaagcaac   1080

agtcacagca ccagttccgc ctcagctgcc ttccgactgg gaggcctttg atactagcct   1140

gtggtctgat ggggggcccc acagaataga ccatcaggag cacccaagag acaggagata   1200

ctccgaacct catcagcaaa gacctccagt atatcgcagg ccaggggact gggactgccc   1260

ttggtgtaac gctgtgaatt tttcacggag ggatacttgc ttcgactgtg ggaagggaat   1320

ctggctgcaa aaacctcatt gagtgcagaa atgcaaaata gaaccgaagc atgtataaaa   1380

aaaaaaaaaa                                                          1390


<210>  4193
<211>  409
<212>  PRT
<213>  Homosapiens

<400>  4193

Met Ala Leu Arg Pro Glu Asp Pro Ser Ser Gly Phe Arg His Ser Asn 
1               5                   10                  15      


Val Val Ala Phe Ile Asn Glu Lys Met Ala Arg His Thr Lys Gly Pro 
            20                  25                  30          


Glu Phe Tyr Leu Glu Asn Ile Ser Leu Ser Trp Glu Lys Val Glu Asp 
        35                  40                  45              


Lys Leu Arg Ala Ile Leu Glu Asp Ser Glu Val Pro Ser Glu Val Lys 
    50                  55                  60                  


Glu Ala Cys Thr Trp Gly Ser Leu Ala Leu Gly Val Arg Phe Ala His 
65                  70                  75                  80  


Arg Gln Ala Gln Leu Gln Arg His Arg Val Arg Trp Leu His Gly Phe 
                85                  90                  95      


Ala Lys Leu His Lys Ser Ala Ala Gln Ala Leu Ala Ser Asp Leu Lys 
            100                 105                 110         


Lys Leu Arg Glu Gln Gln Glu Thr Glu Arg Lys Glu Ala Ala Ser Arg 
        115                 120                 125             


Leu Arg Met Ala Gln Thr Ser Leu Val Glu Val Gln Lys Glu Arg Asp 
    130                 135                 140                 


Lys Glu Leu Val Ser Pro His Glu Trp Glu Gln Gly Ala Gly Trp Pro 
145                 150                 155                 160 


Gly Leu Ala Thr Ala Gly Gly Val Cys Thr Glu Gly Ala Ala Glu Glu 
                165                 170                 175     


Glu Glu Glu Ala Ala Val Ala Ala Ala Gly Ala Ala Gly Gly Lys Gly 
            180                 185                 190         


Ala Glu Glu Glu Gln Arg Asp Val Glu Val Val Ala Ala Pro Val Glu 
        195                 200                 205             


Ala Met Ala Pro Pro Val Glu Ala Gly Ala Ala Pro Met Glu Thr Gln 
    210                 215                 220                 


Phe Pro His Val Glu Ala Arg Ala Ala Ser Met Glu Thr Thr Glu Lys 
225                 230                 235                 240 


Leu Glu Arg Ile Leu Leu Gln Leu Leu Gly Asp Ala Asp Gln Glu Lys 
                245                 250                 255     


Tyr Thr Tyr Trp Gly Gln Lys Glu Gly Asp Leu Arg Ser Val Glu Thr 
            260                 265                 270         


Ala Thr Ser Tyr Phe Ser Gly Thr Thr Asn Pro Trp Ser Arg Ala Ser 
        275                 280                 285             


Ser Glu Pro Leu Pro Val Gln Leu Pro Ala Ser Tyr Ser Tyr Ser Tyr 
    290                 295                 300                 


Ser Ser Pro Phe Ser Ser Phe Ser Asp Ile Pro Thr Ile Ser Pro Pro 
305                 310                 315                 320 


Gln Ala Thr Val Thr Ala Pro Val Pro Pro Gln Leu Pro Ser Asp Trp 
                325                 330                 335     


Glu Ala Phe Asp Thr Ser Leu Trp Ser Asp Gly Gly Pro His Arg Ile 
            340                 345                 350         


Asp His Gln Glu His Pro Arg Asp Arg Arg Tyr Ser Glu Pro His Gln 
        355                 360                 365             


Gln Arg Pro Pro Val Tyr Arg Arg Pro Gly Asp Trp Asp Cys Pro Trp 
    370                 375                 380                 


Cys Asn Ala Val Asn Phe Ser Arg Arg Asp Thr Cys Phe Asp Cys Gly 
385                 390                 395                 400 


Lys Gly Ile Trp Leu Gln Lys Pro His 
                405                 


<210>  4194
<211>  8082
<212>  DNA
<213>  Homosapiens

<400>  4194
ggacagcgct ctcgacacgg agcacccttc tagcttcttc gtctccagga ctgacgctca     60

ggctcctctc tcgccttagc ccaacttgct ttcccgcctc gcaaactccg gtttccctcc    120

actcccaact cttttcacta cacgtttccc ctcctctatc tcccacgcca cgaaccccga    180

tccccagact cctctctccc gccctcctcc ttcctctctc ctcccttcaa ctcttcatcc    240

gcttccacct cagactctgc gcgcacccaa ttcagtcgcc cgctcccgtt cggctcctcg    300

aagccatggc gggacctggg ggctggaggg acagggaggt cacggatctg ggccacctgc    360

cggatccaac tggaatattc tcactagata aaaccattgg ccttggtact tatggcagaa    420

tctatttggg acttcatgag aagactggtg catttacagc tgttaaagtg atgaacgctc    480

gtaagacccc tttacctgaa ataggaaggc gagtgagagt gaataaatat caaaaatctg    540

ttgggtggag atacagtgat gaggaagagg atctcaggac tgaactcaac cttctgagga    600

agtactcttt ccacaaaaac attgtgtcct tctatggagc atttttcaag ctgagtcccc    660

ctggtcagcg gcaccaactt tggatggtga tggagttatg tgcagcaggt tcggtcactg    720

atgtagtgag aatgaccagt aatcagagtt taaaagaagg ttggattgct tatatctgcc    780

gagaaatcct tcagggctta gctcaccttc acgcacaccg agtaattcac cgggacatca    840

aaggtcagaa tgtgctgctg actcataatg ctgaagtaaa actggttgat tttggagtga    900

gtgcccaggt gagcagaact aatggaagaa ggaatagttt cattgggaca ccatactgga    960

tggcacctga ggtgattgac tgtgatgagg acccaagacg ctcctatgat tacagaagtg   1020

atgtgtggtc tgtgggaatt actgccattg aaatggctga aggagcccct cctctgtgta   1080

accttcaacc cttggaagct ctcttcgtta ttttgcggga atctgctccc acagtcaaat   1140

ccagcggatg gtcccgtaag ttccacaatt tcatggaaaa gtgtacgata aaaaatttcc   1200

tgtttcgtcc tacttctgca aacatgcttc aacacccatt tgttcgggat ataaaaaatg   1260

aacgacatgt tgttgagtca ttaacaaggc atcttactgg aatcattaaa aaaagacaga   1320

aaaaaggaat acctttgatc tttgaaagag aagaagctat taaggaacag tacaccgtga   1380

gaagattcag aggaccctct tgcactcacg agcttctgag attgccaacc agcagcagat   1440

gcagaccact tagagtcctg catggggaac cctctcagcc aaggtggcta cctgatcgag   1500

aagagccaca ggtccaggca cttcagcagc tacagggagc agccagggta ttcatgccac   1560

tgcaggctct ggacagtgca cctaagcctc taaaggggca ggctcaggca cctcaacgac   1620

tacaaggggc agctcgggtg ttcatgccac tacaggctca ggtgaaggct aaggcctcta   1680

aacctctaca aatgcagatt aaggcacctc cacgactacg gagggcagcc agggtgctca   1740

tgccactaca ggcacaggtt agggcaccta ggcttctgca ggtacagtcc caggtatcca   1800

aaaagcagca ggcccagacc cagacatcag aaccacaaga tttggaccag gtaccagagg   1860

aatttcagag tcaagatcag gtacccgaac aacaaaggca gggccaggcc cctgaacaac   1920

agcagaggca caaccaggtg cctgaacaag agctggagca gaaccaggca cctgaacagc   1980

cagaggtaca ggaacaggct gccgagcctg cacaggcagg gactgaggca gaggaacctg   2040

agtcattacg agtaaatgcc caggtatttc tgcccctgct atcacaagat caccatgtgc   2100

tgttgccact acatttggat actcaggtgc tcattccagt agaggggcaa actgaaggat   2160

cacctcaggc acaggcttgg acactagagc ccccacaggc aattggctca gttcaagcac   2220

tgatagaggg actatcaaga gacttgcttc gggcgccaaa ctcaaataac tcaaagccac   2280

ttggtccgtt gcaaaccctg atggaaaatc tgtcatcaaa taggttttac tcacaaccag   2340

aacaggcacg ggagaaaaaa tcaaaagttt ctactctgag gcaagcactg gcaaaaagac   2400

tatcaccaaa gaggttcggg gcaaagtcat catggagacc tgaaaagctt gaactctcgg   2460

atttagaagc ccgcaggcaa aggcgccaac gcagatggga agatatcttt aatcagcatg   2520

aggaagaatt gagacaagtt gataaagaca aagaagatga atcatcagac aatgatgaag   2580

tatttcattc gattcaggct gaagtccaga tagagccatt gaagccatac atttcaaatc   2640

ctaaaaaaat tgaggttcaa gagagatctc cttctgtgcc taacaaccag gatcatgcac   2700

atcatgtcaa gttctcttca agcgttcctc agcggtctct tttggaacaa gctcagaagc   2760

ccattgacat cagacaaagg agttcgcaaa atcgtcaaaa ttggctggca gcatcagaat   2820

cttcttctga ggaagaaagt cctgtgactg gaaggaggtc tcagtcatca ccaccttatt   2880

ctactattga tcagaagttg ctggttgaca tccatgttcc agatggattt aaagtaggaa   2940

aaatatcacc ccctgtatac ttgacaaacg aatgggtagg ctataatgca ctctctgaaa   3000

tcttccggaa tgattggtta actccggcac ctgtcattca gccacctgaa gaggatggtg   3060

attatgttga actctatgat gccagtgctg atactgatgg tgatgatgat gatgagtcta   3120

atgatacttt tgaagatacc tatgatcatg ccaatggcaa tgatgacttg gataaccagg   3180

ttgatcaggc taatgatgtt tgtaaagacc atgatgatga caacaataag tttgttgatg   3240

atgtaaataa taattattat gaggcgccta gttgtccaag ggcaagctat ggcagagatg   3300

gaagctgcaa gcaagatggt tatgatggaa gtcgtggaaa agaggaagcc tacagaggct   3360

atggaagcca tacagccaat agaagccatg gaggaagtgc agccagtgag gacaatgcag   3420

ccattggaga tcaggaagaa catgcagcca atataggcag tgaaagaaga ggcagtgagg   3480

gtgatggagg taagggagtc gttcgaacca gtgaagagag tggagccctt ggactcaatg   3540

gagaagaaaa ttgctcagag acagatggtc caggattgaa gagacctgcg tctcaggact   3600

ttgaatatct acaggaggag ccaggtggtg gaaatgaggc ctcaaatgcc attgactcag   3660

gtgctgcacc gtcagcacct gatcatgaga gtgacaataa ggacatatca gaatcaccaa   3720

cacaatcaga tttttctgcc aatcactcat ctccttccaa aggttctggg atgtctgctg   3780

atgctaactt tgccagtgcc atcttatacg ctggattcgt agaagtacct gaggaatcac   3840

ctaagcaacc ctctgaagtc aatgttaacc cactctatgt ctctcctgca tgtaaaaaac   3900

cactaatcca catgtatgaa aaggagttca cttctgagat ctgctgcggt tctttgtggg   3960

gagtcaattt gctgttggga acccgatcta atctatatct gatggacaga agtggaaagg   4020

ctgacattac taaacttata aggcgaagac cattccgcca gattcaagtc ttagagccac   4080

tcaatttgct gattaccatc tcaggtcata agaacagact tcgggtgtat catctgacct   4140

ggttgaggaa caagattttg aataatgatc cagaaagtaa aagaaggcaa gaagaaatgc   4200

tgaagacaga ggaagcctgc aaagctattg ataagttaac aggctgtgaa cacttcagtg   4260

tcctccaaca tgaagaaaca acatatattg caattgcttt gaaatcatca attcaccttt   4320

atgcatgggc accaaagtcc tttgatgaaa gcactgctat taaagtatgc attgatcaat   4380

cagcagactc tgaaggagac tacatgtcct atcaagccta tatacgaata ctggcaaaaa   4440

tacaggcagc tgatccagtg aaccggttta agagaccaga tgagctcctt catttgctga   4500

agctcaaggt atttccaaca cttgatcata agccagtgac agttgacctg gctattggtt   4560

ctgaaaaaag actaaagatt ttcttcagct cagcagatgg atatcacctc atcgatgcag   4620

aatctgaggt tatgtctgat gtgaccctgc caaagaatcc cctggaaatc attataccac   4680

agaatatcat cattttacct gattgcttgg gaattggcat gatgctcacc ttcaatgctg   4740

aagccctctc tgtggaagca aatgaacaac tcttcaagaa gatccttgaa atgtggaaag   4800

acataccatc ttctatagct tttgaatgta cacagcgaac cacaggatgg ggccaaaagg   4860

ccattgaagt gcgctctttg caatccaggg ttctggaaag tgagctgaag cgcaggtcaa   4920

ttaagaagct gagattcctg tgcacccggg gtgacaagct gttctttacc tctaccctgc   4980

gcaatcacca cagccgggtt tacttcatga cacttggaaa acttgaagag ctccaaagca   5040

attatgatgt ctaaaagttt ccagtgattt attaccacat tataaacatc atgtataggc   5100

agtctgcatc ttcagatttc agagattaaa tgagtattca gttttatttt tagtaaagat   5160

taaatccaaa actttacttt taatgtagca cagaatagtt ttaatgagaa atgcagcttt   5220

atgtataaaa ttaactatag caagctctag gtactccaat ggtgtacaat gtcttttgca   5280

caaactttgt aacttttgtt actgtgaatt caaacattac tctttggaca gtttggacag   5340

tatctgtatt cagattttac aacatggagt aaagaaacct gttatgaatt agattacaag   5400

cagccttcaa aagaattggc actgggataa gatttttcag aaaaagaaaa acatcggcaa   5460

actgtgtgtg atttttccaa agctatataa agaaccaaag gtttagtcaa gaaacaaaaa   5520

tcttaaagat tattataacc cagactaagg ttgaacaacc tgcatgccca gagaaaacta   5580

tggcgacaaa ggggaaaagg ccaccactcg ttttctcact gattcatgcc aattaagcct   5640

acagttaaag accagttttg ttcttttcac ccatttttaa gctggttttc tcctgataag   5700

aagaaaggaa gaaagcccca gacgcttggt ttttctcaga acccccaaaa gatgtgcaat   5760

agctgttgtt acaaaccacc aaataataca gttgtgagcc tgaatacagg actgaactcc   5820

tatacacgtg tactgtagaa tgagtatttt ttaatacctt aaggtaggcg tcaaattcta   5880

ctccccaaag cagagatgga ttgatttatc aaaattatta tctggccaac agtgtgacta   5940

tcagacagca tcaaatattt gcccaatcca agattagact acacaaaagc ttccttccag   6000

tattaaacaa aaagaattaa acataactat gaaaaaactt tgctaatatc tgtgtttttc   6060

agatttcatt ttttgtaaaa tcagaaatta atctaaacat attcagtgat aagttcatgt   6120

gtaacgactt aatgttaaag gttaaaaaaa agatttcaca aaatatacaa ctttcaccat   6180

atatataagc ctgcaaaatt agagtagtga aagtcatgct agtccatcac ccaaatatgt   6240

tatagacgcc atagacaggt gatgtttggt cacctatggt aactgctacc tgatgaagag   6300

cataatttct gcatatccat cctcaatacc atggtaaatt ctggggcaat agagaagcaa   6360

cagaactgcc acaaagtata cctcaatata attcctctag ttctgcttct aaaatctgag   6420

gacagtgcta gtgggaaaat aattttcaaa ctacctggtt aaccaaaata caaaagcagc   6480

tgactatgtg tgatttcata atagcacatt tcttgacact tagtgctaga aatgaagatt   6540

tggattttcc taacaactta catcaagaat gtagtgtagc tcattattga gaatttagga   6600

aagcctgaat ccattaatta aggaaataaa tgtgactcac atttctttta ctgtgacaca   6660

ataatgtgat cctaaaactg gcttatcctt gagtgtttac aactcaaaca actttttgaa   6720

tgcagtagtt tttttttttt aaaaacaaac ttttatgtca aatttttttt cttagaagta   6780

gtcttcatta ttataaattt gtacaccaaa aggccatggg gaactttgtg caagtacctc   6840

atcgctgagc aaatggagct tgctatgttt taatttcaga aaatttcctc atatacgtag   6900

tgtgtagaat caagtctttt aataattcat tttttcttca taatatttac tcaaagttaa   6960

gcttaaaaat aagttttatc ttaaaatcat atttgaagac agtaagacag taaactattt   7020

taggaagtca acccccattg cactctgtgg cagttattct ggtaaaaata ggcaaaagtg   7080

acctgaatct acaatgatgt cccaaagtaa ccaagtaaga gagattgtaa atgataaacc   7140

gagctttaaa ggataaagtg ttaataaaga aaggaagctg ggcacatgtc aaaaagggag   7200

atcgaaatgt taggtaatca tttagaaagg acagaaaata tttaaagtgg ctcataggta   7260

atgaatattt ctgacttaga tgtaaatcca tctggaatct ttacatcctt tgccagctga   7320

aacaagaaag tgaagggaca atgatatttc atggtcagtt tattttgtaa gagacagaag   7380

aaattatatc tatacattac cttgtagcag cagtacctgg aagccccagc ccgtcacaga   7440

agtgtggagg ggggctcctg actagacaat ttccctagcc cttgtgattt gaagcatgaa   7500

agttctggca ggttatgagc agcactaggg ataaagtatg gttttatttt ggtgtaattt   7560

aggtttttca acaaagccct tgtctaaaat aaaaggcatt attggaaata tttgaaaact   7620

agaaaatgat ggataaaagg gctgataaga aaatttctgg ctgtcagtag aagtgagata   7680

agatcctcag aggaaacagt aagaagggat aatcattaag atagtaaaac aggcaaagca   7740

gaatcacatg tgcacacaca catacacatg taaacattgg aatgcataag ttttaatatt   7800

ttagcgctat cagtttctaa atgcattaat tactaactgc cctctcccaa gattcattta   7860

gttcaaacag tatccgtaaa ctaggaataa tgccacatgc attcaatggg accttttaag   7920

tactcttcag tttgttccaa gaaatgtgcc tactgaaatc aaattaattt gtattcaatg   7980

tgtacttcaa gactgctaat tgtttcatct gaaagcctac aatgaatcat tgttcaacct   8040

tgaaaaataa aattttgtaa atcaaaaaaa aaaaaaaaaa aa                      8082


<210>  4195
<211>  1582
<212>  PRT
<213>  Homosapiens

<400>  4195

Met Ala Gly Pro Gly Gly Trp Arg Asp Arg Glu Val Thr Asp Leu Gly 
1               5                   10                  15      


His Leu Pro Asp Pro Thr Gly Ile Phe Ser Leu Asp Lys Thr Ile Gly 
            20                  25                  30          


Leu Gly Thr Tyr Gly Arg Ile Tyr Leu Gly Leu His Glu Lys Thr Gly 
        35                  40                  45              


Ala Phe Thr Ala Val Lys Val Met Asn Ala Arg Lys Thr Pro Leu Pro 
    50                  55                  60                  


Glu Ile Gly Arg Arg Val Arg Val Asn Lys Tyr Gln Lys Ser Val Gly 
65                  70                  75                  80  


Trp Arg Tyr Ser Asp Glu Glu Glu Asp Leu Arg Thr Glu Leu Asn Leu 
                85                  90                  95      


Leu Arg Lys Tyr Ser Phe His Lys Asn Ile Val Ser Phe Tyr Gly Ala 
            100                 105                 110         


Phe Phe Lys Leu Ser Pro Pro Gly Gln Arg His Gln Leu Trp Met Val 
        115                 120                 125             


Met Glu Leu Cys Ala Ala Gly Ser Val Thr Asp Val Val Arg Met Thr 
    130                 135                 140                 


Ser Asn Gln Ser Leu Lys Glu Gly Trp Ile Ala Tyr Ile Cys Arg Glu 
145                 150                 155                 160 


Ile Leu Gln Gly Leu Ala His Leu His Ala His Arg Val Ile His Arg 
                165                 170                 175     


Asp Ile Lys Gly Gln Asn Val Leu Leu Thr His Asn Ala Glu Val Lys 
            180                 185                 190         


Leu Val Asp Phe Gly Val Ser Ala Gln Val Ser Arg Thr Asn Gly Arg 
        195                 200                 205             


Arg Asn Ser Phe Ile Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Ile 
    210                 215                 220                 


Asp Cys Asp Glu Asp Pro Arg Arg Ser Tyr Asp Tyr Arg Ser Asp Val 
225                 230                 235                 240 


Trp Ser Val Gly Ile Thr Ala Ile Glu Met Ala Glu Gly Ala Pro Pro 
                245                 250                 255     


Leu Cys Asn Leu Gln Pro Leu Glu Ala Leu Phe Val Ile Leu Arg Glu 
            260                 265                 270         


Ser Ala Pro Thr Val Lys Ser Ser Gly Trp Ser Arg Lys Phe His Asn 
        275                 280                 285             


Phe Met Glu Lys Cys Thr Ile Lys Asn Phe Leu Phe Arg Pro Thr Ser 
    290                 295                 300                 


Ala Asn Met Leu Gln His Pro Phe Val Arg Asp Ile Lys Asn Glu Arg 
305                 310                 315                 320 


His Val Val Glu Ser Leu Thr Arg His Leu Thr Gly Ile Ile Lys Lys 
                325                 330                 335     


Arg Gln Lys Lys Gly Ile Pro Leu Ile Phe Glu Arg Glu Glu Ala Ile 
            340                 345                 350         


Lys Glu Gln Tyr Thr Val Arg Arg Phe Arg Gly Pro Ser Cys Thr His 
        355                 360                 365             


Glu Leu Leu Arg Leu Pro Thr Ser Ser Arg Cys Arg Pro Leu Arg Val 
    370                 375                 380                 


Leu His Gly Glu Pro Ser Gln Pro Arg Trp Leu Pro Asp Arg Glu Glu 
385                 390                 395                 400 


Pro Gln Val Gln Ala Leu Gln Gln Leu Gln Gly Ala Ala Arg Val Phe 
                405                 410                 415     


Met Pro Leu Gln Ala Leu Asp Ser Ala Pro Lys Pro Leu Lys Gly Gln 
            420                 425                 430         


Ala Gln Ala Pro Gln Arg Leu Gln Gly Ala Ala Arg Val Phe Met Pro 
        435                 440                 445             


Leu Gln Ala Gln Val Lys Ala Lys Ala Ser Lys Pro Leu Gln Met Gln 
    450                 455                 460                 


Ile Lys Ala Pro Pro Arg Leu Arg Arg Ala Ala Arg Val Leu Met Pro 
465                 470                 475                 480 


Leu Gln Ala Gln Val Arg Ala Pro Arg Leu Leu Gln Val Gln Ser Gln 
                485                 490                 495     


Val Ser Lys Lys Gln Gln Ala Gln Thr Gln Thr Ser Glu Pro Gln Asp 
            500                 505                 510         


Leu Asp Gln Val Pro Glu Glu Phe Gln Ser Gln Asp Gln Val Pro Glu 
        515                 520                 525             


Gln Gln Arg Gln Gly Gln Ala Pro Glu Gln Gln Gln Arg His Asn Gln 
    530                 535                 540                 


Val Pro Glu Gln Glu Leu Glu Gln Asn Gln Ala Pro Glu Gln Pro Glu 
545                 550                 555                 560 


Val Gln Glu Gln Ala Ala Glu Pro Ala Gln Ala Gly Thr Glu Ala Glu 
                565                 570                 575     


Glu Pro Glu Ser Leu Arg Val Asn Ala Gln Val Phe Leu Pro Leu Leu 
            580                 585                 590         


Ser Gln Asp His His Val Leu Leu Pro Leu His Leu Asp Thr Gln Val 
        595                 600                 605             


Leu Ile Pro Val Glu Gly Gln Thr Glu Gly Ser Pro Gln Ala Gln Ala 
    610                 615                 620                 


Trp Thr Leu Glu Pro Pro Gln Ala Ile Gly Ser Val Gln Ala Leu Ile 
625                 630                 635                 640 


Glu Gly Leu Ser Arg Asp Leu Leu Arg Ala Pro Asn Ser Asn Asn Ser 
                645                 650                 655     


Lys Pro Leu Gly Pro Leu Gln Thr Leu Met Glu Asn Leu Ser Ser Asn 
            660                 665                 670         


Arg Phe Tyr Ser Gln Pro Glu Gln Ala Arg Glu Lys Lys Ser Lys Val 
        675                 680                 685             


Ser Thr Leu Arg Gln Ala Leu Ala Lys Arg Leu Ser Pro Lys Arg Phe 
    690                 695                 700                 


Gly Ala Lys Ser Ser Trp Arg Pro Glu Lys Leu Glu Leu Ser Asp Leu 
705                 710                 715                 720 


Glu Ala Arg Arg Gln Arg Arg Gln Arg Arg Trp Glu Asp Ile Phe Asn 
                725                 730                 735     


Gln His Glu Glu Glu Leu Arg Gln Val Asp Lys Asp Lys Glu Asp Glu 
            740                 745                 750         


Ser Ser Asp Asn Asp Glu Val Phe His Ser Ile Gln Ala Glu Val Gln 
        755                 760                 765             


Ile Glu Pro Leu Lys Pro Tyr Ile Ser Asn Pro Lys Lys Ile Glu Val 
    770                 775                 780                 


Gln Glu Arg Ser Pro Ser Val Pro Asn Asn Gln Asp His Ala His His 
785                 790                 795                 800 


Val Lys Phe Ser Ser Ser Val Pro Gln Arg Ser Leu Leu Glu Gln Ala 
                805                 810                 815     


Gln Lys Pro Ile Asp Ile Arg Gln Arg Ser Ser Gln Asn Arg Gln Asn 
            820                 825                 830         


Trp Leu Ala Ala Ser Glu Ser Ser Ser Glu Glu Glu Ser Pro Val Thr 
        835                 840                 845             


Gly Arg Arg Ser Gln Ser Ser Pro Pro Tyr Ser Thr Ile Asp Gln Lys 
    850                 855                 860                 


Leu Leu Val Asp Ile His Val Pro Asp Gly Phe Lys Val Gly Lys Ile 
865                 870                 875                 880 


Ser Pro Pro Val Tyr Leu Thr Asn Glu Trp Val Gly Tyr Asn Ala Leu 
                885                 890                 895     


Ser Glu Ile Phe Arg Asn Asp Trp Leu Thr Pro Ala Pro Val Ile Gln 
            900                 905                 910         


Pro Pro Glu Glu Asp Gly Asp Tyr Val Glu Leu Tyr Asp Ala Ser Ala 
        915                 920                 925             


Asp Thr Asp Gly Asp Asp Asp Asp Glu Ser Asn Asp Thr Phe Glu Asp 
    930                 935                 940                 


Thr Tyr Asp His Ala Asn Gly Asn Asp Asp Leu Asp Asn Gln Val Asp 
945                 950                 955                 960 


Gln Ala Asn Asp Val Cys Lys Asp His Asp Asp Asp Asn Asn Lys Phe 
                965                 970                 975     


Val Asp Asp Val Asn Asn Asn Tyr Tyr Glu Ala Pro Ser Cys Pro Arg 
            980                 985                 990         


Ala Ser Tyr Gly Arg Asp Gly Ser  Cys Lys Gln Asp Gly  Tyr Asp Gly 
        995                 1000                 1005             


Ser Arg  Gly Lys Glu Glu Ala  Tyr Arg Gly Tyr Gly  Ser His Thr 
    1010                 1015                 1020             


Ala Asn  Arg Ser His Gly Gly  Ser Ala Ala Ser Glu  Asp Asn Ala 
    1025                 1030                 1035             


Ala Ile  Gly Asp Gln Glu Glu  His Ala Ala Asn Ile  Gly Ser Glu 
    1040                 1045                 1050             


Arg Arg  Gly Ser Glu Gly Asp  Gly Gly Lys Gly Val  Val Arg Thr 
    1055                 1060                 1065             


Ser Glu  Glu Ser Gly Ala Leu  Gly Leu Asn Gly Glu  Glu Asn Cys 
    1070                 1075                 1080             


Ser Glu  Thr Asp Gly Pro Gly  Leu Lys Arg Pro Ala  Ser Gln Asp 
    1085                 1090                 1095             


Phe Glu  Tyr Leu Gln Glu Glu  Pro Gly Gly Gly Asn  Glu Ala Ser 
    1100                 1105                 1110             


Asn Ala  Ile Asp Ser Gly Ala  Ala Pro Ser Ala Pro  Asp His Glu 
    1115                 1120                 1125             


Ser Asp  Asn Lys Asp Ile Ser  Glu Ser Pro Thr Gln  Ser Asp Phe 
    1130                 1135                 1140             


Ser Ala  Asn His Ser Ser Pro  Ser Lys Gly Ser Gly  Met Ser Ala 
    1145                 1150                 1155             


Asp Ala  Asn Phe Ala Ser Ala  Ile Leu Tyr Ala Gly  Phe Val Glu 
    1160                 1165                 1170             


Val Pro  Glu Glu Ser Pro Lys  Gln Pro Ser Glu Val  Asn Val Asn 
    1175                 1180                 1185             


Pro Leu  Tyr Val Ser Pro Ala  Cys Lys Lys Pro Leu  Ile His Met 
    1190                 1195                 1200             


Tyr Glu  Lys Glu Phe Thr Ser  Glu Ile Cys Cys Gly  Ser Leu Trp 
    1205                 1210                 1215             


Gly Val  Asn Leu Leu Leu Gly  Thr Arg Ser Asn Leu  Tyr Leu Met 
    1220                 1225                 1230             


Asp Arg  Ser Gly Lys Ala Asp  Ile Thr Lys Leu Ile  Arg Arg Arg 
    1235                 1240                 1245             


Pro Phe  Arg Gln Ile Gln Val  Leu Glu Pro Leu Asn  Leu Leu Ile 
    1250                 1255                 1260             


Thr Ile  Ser Gly His Lys Asn  Arg Leu Arg Val Tyr  His Leu Thr 
    1265                 1270                 1275             


Trp Leu  Arg Asn Lys Ile Leu  Asn Asn Asp Pro Glu  Ser Lys Arg 
    1280                 1285                 1290             


Arg Gln  Glu Glu Met Leu Lys  Thr Glu Glu Ala Cys  Lys Ala Ile 
    1295                 1300                 1305             


Asp Lys  Leu Thr Gly Cys Glu  His Phe Ser Val Leu  Gln His Glu 
    1310                 1315                 1320             


Glu Thr  Thr Tyr Ile Ala Ile  Ala Leu Lys Ser Ser  Ile His Leu 
    1325                 1330                 1335             


Tyr Ala  Trp Ala Pro Lys Ser  Phe Asp Glu Ser Thr  Ala Ile Lys 
    1340                 1345                 1350             


Val Cys  Ile Asp Gln Ser Ala  Asp Ser Glu Gly Asp  Tyr Met Ser 
    1355                 1360                 1365             


Tyr Gln  Ala Tyr Ile Arg Ile  Leu Ala Lys Ile Gln  Ala Ala Asp 
    1370                 1375                 1380             


Pro Val  Asn Arg Phe Lys Arg  Pro Asp Glu Leu Leu  His Leu Leu 
    1385                 1390                 1395             


Lys Leu  Lys Val Phe Pro Thr  Leu Asp His Lys Pro  Val Thr Val 
    1400                 1405                 1410             


Asp Leu  Ala Ile Gly Ser Glu  Lys Arg Leu Lys Ile  Phe Phe Ser 
    1415                 1420                 1425             


Ser Ala  Asp Gly Tyr His Leu  Ile Asp Ala Glu Ser  Glu Val Met 
    1430                 1435                 1440             


Ser Asp  Val Thr Leu Pro Lys  Asn Pro Leu Glu Ile  Ile Ile Pro 
    1445                 1450                 1455             


Gln Asn  Ile Ile Ile Leu Pro  Asp Cys Leu Gly Ile  Gly Met Met 
    1460                 1465                 1470             


Leu Thr  Phe Asn Ala Glu Ala  Leu Ser Val Glu Ala  Asn Glu Gln 
    1475                 1480                 1485             


Leu Phe  Lys Lys Ile Leu Glu  Met Trp Lys Asp Ile  Pro Ser Ser 
    1490                 1495                 1500             


Ile Ala  Phe Glu Cys Thr Gln  Arg Thr Thr Gly Trp  Gly Gln Lys 
    1505                 1510                 1515             


Ala Ile  Glu Val Arg Ser Leu  Gln Ser Arg Val Leu  Glu Ser Glu 
    1520                 1525                 1530             


Leu Lys  Arg Arg Ser Ile Lys  Lys Leu Arg Phe Leu  Cys Thr Arg 
    1535                 1540                 1545             


Gly Asp  Lys Leu Phe Phe Thr  Ser Thr Leu Arg Asn  His His Ser 
    1550                 1555                 1560             


Arg Val  Tyr Phe Met Thr Leu  Gly Lys Leu Glu Glu  Leu Gln Ser 
    1565                 1570                 1575             


Asn Tyr  Asp Val 
    1580         


<210>  4196
<211>  1559
<212>  DNA
<213>  Homosapiens

<400>  4196
attaacttcc ttccaaaatg tcaccattcc tgtacctggt tctcttggta cttgggcttc     60

atgctacaat ccactgtgca tcacctgaag gcaaagtaac agcctgccat tcatcccaac    120

caaatgccac tctctacaag atgtcatcca ttaatgctga ctttgcattc aatctgtacc    180

ggaggttcac tgtggagacc ccagataaga acatcttctt ttcccctgtg agcatttctg    240

cagctttggt tatgctttcc tttggggcct gctgcagcac ccaaactgag attgtggaga    300

ccttggggtt caacctcaca gacactccaa tggtagagat ccagcatggc ttccagcatc    360

tgatctgttc actgaatttt ccaaagaagg aactggaatt gcagatagga aatgccctct    420

tcattggcaa gcatctgaaa ccactggcaa agttcttgaa tgatgtcaag accctctatg    480

agactgaagt cttttctacc gacttctcca acatttctgc agccaagcag gagattaaca    540

gtcatgtgga gatgcaaacc aaagggaaag ttgtgggtct aattcaagac ctcaagccaa    600

acaccactat ggtcttagtg aactatattc actttaaagc ccagtgggca aatccttttg    660

atccatccaa gacagaagac agttccagct tcttaataga caagaccacc actgttcaag    720

tgcccatgat gcaccagatg gaacaatact atcacctagt ggatatggaa ttgaactgca    780

cagttctgca aatggactac agcaagaatg ctctggcact ctttgttctt cccaaggagg    840

gacagatgga gtcagtggaa gctgccatgt catctaaaac actgaagaag tggaaccgct    900

tactacagaa gggatgggtt gacttgtttg ttccaaagtt ttccatttct gccacatatg    960

accttggagc cacacttttg aagatgggca ttcagcatgc ctattctgaa aatgctgatt   1020

tttctggact cacagaggac aatggtctga aactttccaa tgctgcccat aaggctgtgc   1080

tgcacattgg tgaaaaggga actgaagctg cagctgtccc tgaagttgaa ctttcggatc   1140

agcctgaaaa cactttccta caccctatta tccaaattga tagatctttc atgttgttga   1200

ttttggagag aagcacaagg agtattctct ttctagggaa agttgtgaac ccaacggaag   1260

cgtagttggg aaaaaggcca ttggctaatt gcacgtgtgt attgcaatgg gaaataaata   1320

aataatatag cctggtgtga ttgatgtgag cttggacttg cattccctta tgatgggatg   1380

aagattgaac cctggctgaa ctttgttggc tgtggaagag gccaatccta tggcagagca   1440

ttcagaatgt caatgagtaa ttcattatta tccaaagcat aggaaggctc tatgtttgta   1500

tatttctctt tgtcagaata cccctcaact catttgctct aataaatttg actgggttg    1559


<210>  4197
<211>  415
<212>  PRT
<213>  Homosapiens

<400>  4197

Met Ser Pro Phe Leu Tyr Leu Val Leu Leu Val Leu Gly Leu His Ala 
1               5                   10                  15      


Thr Ile His Cys Ala Ser Pro Glu Gly Lys Val Thr Ala Cys His Ser 
            20                  25                  30          


Ser Gln Pro Asn Ala Thr Leu Tyr Lys Met Ser Ser Ile Asn Ala Asp 
        35                  40                  45              


Phe Ala Phe Asn Leu Tyr Arg Arg Phe Thr Val Glu Thr Pro Asp Lys 
    50                  55                  60                  


Asn Ile Phe Phe Ser Pro Val Ser Ile Ser Ala Ala Leu Val Met Leu 
65                  70                  75                  80  


Ser Phe Gly Ala Cys Cys Ser Thr Gln Thr Glu Ile Val Glu Thr Leu 
                85                  90                  95      


Gly Phe Asn Leu Thr Asp Thr Pro Met Val Glu Ile Gln His Gly Phe 
            100                 105                 110         


Gln His Leu Ile Cys Ser Leu Asn Phe Pro Lys Lys Glu Leu Glu Leu 
        115                 120                 125             


Gln Ile Gly Asn Ala Leu Phe Ile Gly Lys His Leu Lys Pro Leu Ala 
    130                 135                 140                 


Lys Phe Leu Asn Asp Val Lys Thr Leu Tyr Glu Thr Glu Val Phe Ser 
145                 150                 155                 160 


Thr Asp Phe Ser Asn Ile Ser Ala Ala Lys Gln Glu Ile Asn Ser His 
                165                 170                 175     


Val Glu Met Gln Thr Lys Gly Lys Val Val Gly Leu Ile Gln Asp Leu 
            180                 185                 190         


Lys Pro Asn Thr Thr Met Val Leu Val Asn Tyr Ile His Phe Lys Ala 
        195                 200                 205             


Gln Trp Ala Asn Pro Phe Asp Pro Ser Lys Thr Glu Asp Ser Ser Ser 
    210                 215                 220                 


Phe Leu Ile Asp Lys Thr Thr Thr Val Gln Val Pro Met Met His Gln 
225                 230                 235                 240 


Met Glu Gln Tyr Tyr His Leu Val Asp Met Glu Leu Asn Cys Thr Val 
                245                 250                 255     


Leu Gln Met Asp Tyr Ser Lys Asn Ala Leu Ala Leu Phe Val Leu Pro 
            260                 265                 270         


Lys Glu Gly Gln Met Glu Ser Val Glu Ala Ala Met Ser Ser Lys Thr 
        275                 280                 285             


Leu Lys Lys Trp Asn Arg Leu Leu Gln Lys Gly Trp Val Asp Leu Phe 
    290                 295                 300                 


Val Pro Lys Phe Ser Ile Ser Ala Thr Tyr Asp Leu Gly Ala Thr Leu 
305                 310                 315                 320 


Leu Lys Met Gly Ile Gln His Ala Tyr Ser Glu Asn Ala Asp Phe Ser 
                325                 330                 335     


Gly Leu Thr Glu Asp Asn Gly Leu Lys Leu Ser Asn Ala Ala His Lys 
            340                 345                 350         


Ala Val Leu His Ile Gly Glu Lys Gly Thr Glu Ala Ala Ala Val Pro 
        355                 360                 365             


Glu Val Glu Leu Ser Asp Gln Pro Glu Asn Thr Phe Leu His Pro Ile 
    370                 375                 380                 


Ile Gln Ile Asp Arg Ser Phe Met Leu Leu Ile Leu Glu Arg Ser Thr 
385                 390                 395                 400 


Arg Ser Ile Leu Phe Leu Gly Lys Val Val Asn Pro Thr Glu Ala 
                405                 410                 415 


<210>  4198
<211>  3958
<212>  DNA
<213>  Homosapiens

<400>  4198
ttttcaagag gctgcagctg acaagaagct tcaagcatag gttaatatca gagaagcaca     60

tgacctgggc aatctgcatg tgatgccaac caagccttgg aaagacagtg caaccacaga    120

agtgccgagc tgggtaaagg ccctgctgga caagcagttg gagtgagaat caagacagcc    180

ggaccacagg accagaccca ccaggatcca catgacagtg gtatcttccg gtatcatcct    240

attcaaacaa cgtgttcaag catccttgga aaattgaggt ggagaacagg ccacacaagc    300

tgtaaaccct ttgtagtcat aagacgaaag aggatttgtt aagagtattg ttttgggtag    360

aacttgcatt agcagtgaca aagatagcca cctcaacctt tggtaataac ccttggcaca    420

caaatataaa ccataatgga gtctgagtat gtcctatgcg actggaaaga ccagttgtgg    480

ccagcaaaag ttttgtccag atctgaaact tcatcaaaca gtaagaggaa aaaggcattt    540

tctctagaag ttcaaatact ctcactagat gaaaaaatta aattggacag cacagaaaca    600

aagatcctaa ataaatctca aattgaagcc attgctgcct cattaggact acagtcagag    660

gacagtgctc cacctacaga ggaaactgcc tatggaagat cactaaaagt ggcactgggt    720

attctgaatg agagaacaaa tttgagtcaa gcaagcactt cagatgaaga ggagatcact    780

atgctgtctc aaaatgtacc acaaaaacag tccgattcac cccctcataa aaaataccgg    840

aaggatgaag gtgacttacc agggtgtctt gaggaaaggg aaaactcagc atgcttgtta    900

gcatcttcag agagtgatga ttccctgtat gatgataaat cacaagcacc cacaatggtc    960

gatactattc caagtgaagt ggaaacaaag tcattacaaa actctagctg gtgcgagact   1020

ttcccttcac tttcggaaga taatgatgaa aaagagaaca agaataagat tgatatctca   1080

gcagttatgt ctgtgcattc tgcagtcaaa gaggaaagtg catgtgttaa agatgaaaag   1140

tttgctccac ctttgtcacc tttgtcatca gatatgctca ttatgcccaa agctttgaaa   1200

gaagagagcg aggatacctg cctagagacc ctggctgttc cctctgaatg ctctgctttc   1260

tcagagaata ttgaggatcc tggagagggt ccctcaaatc catgcttaga taccagccag   1320

aatcaacctt ccatggaatc agagatgggg gctgcagcat gccctgggag ttgttcaagg   1380

gaatgcgagg tttcatttag tgcctctaac cctgtctggg attattcaca tcttatgagt   1440

agtgaaagaa attttcagag actggatttt gaagaacttg aggaagaagg tcaagcctct   1500

gacaagtcat tgcttccaag tcgcattaat ctttctctat tagatgatga tgaggaagac   1560

gaagaacttc cacgcttcat tttacattat gagacacatc cgtttgaaac aggaatgata   1620

gtctggttta aatatcagaa atatccattt tggccagcag tgataaaaag tatcagacga   1680

aaagagagga aagcaagtgt gctttttgtt gaggcaaaca tgaattctga aaagaagggc   1740

attagagtaa attttagaag attaaagaaa tttgattgta aagagaaaca aatgctagtg   1800

gacaaagcca gggaggatta tagtgagagt attgactggt gcatctcact aatttgtgac   1860

tacagagtta gaataggttg tggttctttc acgggctctt tgcttgagta ttatgctgct   1920

gatattagtt acccagttag gaaagaaaca aaacaggata ctttcaggaa caaatttcca   1980

aagctgcata atgaagatgc cagggaaccg atggctgtaa cttcccagac caagaaaatg   2040

tccttccaaa aaattctccc tgaccggatg aaggctgctc gggaccgagc caacaagaac   2100

ctggtggact tcattgtgaa tgcaaaggga acagagaacc atcttctggc cattgtaaat   2160

ggcacaaaag gatccagatg gctgaaatca tttttgaatg caaataggtt cacaccctgt   2220

attgaaacat actttgagga tgaagatcag ttggatgaag tggtgaaata tttacaagaa   2280

gtctgcaatc aaatagatca aataatgcca acttggataa aagatgataa aattaaattt   2340

atcctataag ttcttctgcc agaagcaatt atttgttcaa tttctgctgt tgatgggtta   2400

gattacgagg cagctgaagc aaagtatcta aaaggaccat gtctaggcta cagggaaaga   2460

gaattatttg atgcaaaaat aatatatgaa aagagacgaa aagcaccaac aaatgaagct   2520

cactaaatgt gctgaaagtt gaaaccatga cagggagctc tcatagatac tagttgaaaa   2580

aagtctctga acaattctct ctaatacata ttttctgcaa atgggagcat ggataatgtg   2640

ttcacttttt tttgagatct ctaggatctg tggttataat tacatcttta tttccttttc   2700

ttgcgcttct tcaaagttaa ttttgtcaac atatttcagc agttctactt tcccgtacat   2760

tttttagaaa gcataattcc taaatgattt tgaagggaaa gtactatttt gttttatgac   2820

acttttgagt ctatgctgta ttgttaaata tattgtgcac aattatttta atgttaaaat   2880

tgcactggtg ttagatatta acgaagatga ttggaaaaaa gtctgaaaga tacatcattt   2940

ctatattcct tgcttaattt ttataaaata ttgggttttc ccttaagata gttgaagtat   3000

ttttcttgcc atgcctattt atttttgcaa aaaaattatc tgctatatag aaccaaagat   3060

agattcgctt tgctatatat tataactata cttgcttttg caataaaaca acttgtaatt   3120

caaaaatgaa gattatctgc atatagtatt tatgtgtgtg aataacatct tggcatgcag   3180

aaaataattt tggctgcttt gaacaggatt gttcattcta cacttccctg aaattccatt   3240

tttgggagtg tctatccttc aatggctgaa tagttcctta aatcagacaa gctcctggct   3300

atcttcataa ccagcagtga gtagatcttc ttaatatagc tgtctgacca catgtggaag   3360

gcagctagac ttattgtatt tacagcctgg ccactctaga catatgaatc caggctgact   3420

gcttaagtgc ccatctcgtt tgatataaac tgtagaaaag gcaagcactt tgttctgagt   3480

cttttatctc caaatacata gttgtctcaa accaagcaag ctttatcaaa atggcttatt   3540

tgcagaatag ttccaatgat ataaatgcca actggcaagt cattccaaac tgcttgaagg   3600

agtagatgaa ccagaatctg agaatttgga aataggtcac agaaaaagcc tccatttggc   3660

taaatatgac aattatctga gtatggttaa atacatacaa ttaaatgtct gaagccaatg   3720

agttgtttat tctaacttga aatatatttt tgtgagaata aatgttagaa aagttagttt   3780

attttggaaa cctgccgtga aaggaaattc taaaggctta acatgaaact gtctgcattt   3840

ctacctgtta gacaatggtt gctcttgggc tcttgttata cagtcatatg gctacacgtt   3900

tatgtaaagt ttgcaaaagt ttggtgtttt gatttataat aaaactgtta tattattc     3958


<210>  4199
<211>  637
<212>  PRT
<213>  Homosapiens

<400>  4199

Met Glu Ser Glu Tyr Val Leu Cys Asp Trp Lys Asp Gln Leu Trp Pro 
1               5                   10                  15      


Ala Lys Val Leu Ser Arg Ser Glu Thr Ser Ser Asn Ser Lys Arg Lys 
            20                  25                  30          


Lys Ala Phe Ser Leu Glu Val Gln Ile Leu Ser Leu Asp Glu Lys Ile 
        35                  40                  45              


Lys Leu Asp Ser Thr Glu Thr Lys Ile Leu Asn Lys Ser Gln Ile Glu 
    50                  55                  60                  


Ala Ile Ala Ala Ser Leu Gly Leu Gln Ser Glu Asp Ser Ala Pro Pro 
65                  70                  75                  80  


Thr Glu Glu Thr Ala Tyr Gly Arg Ser Leu Lys Val Ala Leu Gly Ile 
                85                  90                  95      


Leu Asn Glu Arg Thr Asn Leu Ser Gln Ala Ser Thr Ser Asp Glu Glu 
            100                 105                 110         


Glu Ile Thr Met Leu Ser Gln Asn Val Pro Gln Lys Gln Ser Asp Ser 
        115                 120                 125             


Pro Pro His Lys Lys Tyr Arg Lys Asp Glu Gly Asp Leu Pro Gly Cys 
    130                 135                 140                 


Leu Glu Glu Arg Glu Asn Ser Ala Cys Leu Leu Ala Ser Ser Glu Ser 
145                 150                 155                 160 


Asp Asp Ser Leu Tyr Asp Asp Lys Ser Gln Ala Pro Thr Met Val Asp 
                165                 170                 175     


Thr Ile Pro Ser Glu Val Glu Thr Lys Ser Leu Gln Asn Ser Ser Trp 
            180                 185                 190         


Cys Glu Thr Phe Pro Ser Leu Ser Glu Asp Asn Asp Glu Lys Glu Asn 
        195                 200                 205             


Lys Asn Lys Ile Asp Ile Ser Ala Val Met Ser Val His Ser Ala Val 
    210                 215                 220                 


Lys Glu Glu Ser Ala Cys Val Lys Asp Glu Lys Phe Ala Pro Pro Leu 
225                 230                 235                 240 


Ser Pro Leu Ser Ser Asp Met Leu Ile Met Pro Lys Ala Leu Lys Glu 
                245                 250                 255     


Glu Ser Glu Asp Thr Cys Leu Glu Thr Leu Ala Val Pro Ser Glu Cys 
            260                 265                 270         


Ser Ala Phe Ser Glu Asn Ile Glu Asp Pro Gly Glu Gly Pro Ser Asn 
        275                 280                 285             


Pro Cys Leu Asp Thr Ser Gln Asn Gln Pro Ser Met Glu Ser Glu Met 
    290                 295                 300                 


Gly Ala Ala Ala Cys Pro Gly Ser Cys Ser Arg Glu Cys Glu Val Ser 
305                 310                 315                 320 


Phe Ser Ala Ser Asn Pro Val Trp Asp Tyr Ser His Leu Met Ser Ser 
                325                 330                 335     


Glu Arg Asn Phe Gln Arg Leu Asp Phe Glu Glu Leu Glu Glu Glu Gly 
            340                 345                 350         


Gln Ala Ser Asp Lys Ser Leu Leu Pro Ser Arg Ile Asn Leu Ser Leu 
        355                 360                 365             


Leu Asp Asp Asp Glu Glu Asp Glu Glu Leu Pro Arg Phe Ile Leu His 
    370                 375                 380                 


Tyr Glu Thr His Pro Phe Glu Thr Gly Met Ile Val Trp Phe Lys Tyr 
385                 390                 395                 400 


Gln Lys Tyr Pro Phe Trp Pro Ala Val Ile Lys Ser Ile Arg Arg Lys 
                405                 410                 415     


Glu Arg Lys Ala Ser Val Leu Phe Val Glu Ala Asn Met Asn Ser Glu 
            420                 425                 430         


Lys Lys Gly Ile Arg Val Asn Phe Arg Arg Leu Lys Lys Phe Asp Cys 
        435                 440                 445             


Lys Glu Lys Gln Met Leu Val Asp Lys Ala Arg Glu Asp Tyr Ser Glu 
    450                 455                 460                 


Ser Ile Asp Trp Cys Ile Ser Leu Ile Cys Asp Tyr Arg Val Arg Ile 
465                 470                 475                 480 


Gly Cys Gly Ser Phe Thr Gly Ser Leu Leu Glu Tyr Tyr Ala Ala Asp 
                485                 490                 495     


Ile Ser Tyr Pro Val Arg Lys Glu Thr Lys Gln Asp Thr Phe Arg Asn 
            500                 505                 510         


Lys Phe Pro Lys Leu His Asn Glu Asp Ala Arg Glu Pro Met Ala Val 
        515                 520                 525             


Thr Ser Gln Thr Lys Lys Met Ser Phe Gln Lys Ile Leu Pro Asp Arg 
    530                 535                 540                 


Met Lys Ala Ala Arg Asp Arg Ala Asn Lys Asn Leu Val Asp Phe Ile 
545                 550                 555                 560 


Val Asn Ala Lys Gly Thr Glu Asn His Leu Leu Ala Ile Val Asn Gly 
                565                 570                 575     


Thr Lys Gly Ser Arg Trp Leu Lys Ser Phe Leu Asn Ala Asn Arg Phe 
            580                 585                 590         


Thr Pro Cys Ile Glu Thr Tyr Phe Glu Asp Glu Asp Gln Leu Asp Glu 
        595                 600                 605             


Val Val Lys Tyr Leu Gln Glu Val Cys Asn Gln Ile Asp Gln Ile Met 
    610                 615                 620                 


Pro Thr Trp Ile Lys Asp Asp Lys Ile Lys Phe Ile Leu 
625                 630                 635         


<210>  4200
<211>  3861
<212>  DNA
<213>  Homosapiens

<400>  4200
ccacgcgtcc gggacggggc aaactagctt ttgggagtga agcgggtacg cagttatcca     60

acaatgtctg gtgagtcagg acagcctgag gctggtccct cacatgcagg gctagattgg    120

ccgaaccctg agaggaatcg ggctggggtc ccgggagggg tgatccgaag agctggttcc    180

caagggccca ggtcctggat ccaaaaggtt cttgagcaga ttatggactc acctcgccag    240

tgtgtcaccc cctcggaggt ggtgcctgta actgtgctgg ccgtccagag gtacctgtta    300

gaggatgagc cacgcgacac ggtgcccaag cctccccttt attgctatga tgtgacgatc    360

tcagatgggg tgtaccagga gaagtgctac ctggacccca gcttgaactc tctcgtatat    420

caaaatattc ttaaagttgg cattcaaatg agaatttcca gggtctcatg tctttacaat    480

gagaaaagga taggccaggg gatcctgtgc atagataacg tccactgtgg ggagacttca    540

gacagtattt ctttagaaac tcccttcaga aatagagcgc accaggagaa accagagagg    600

cctttaagag gcgggaagag tcattacctg gcgctgtgga ataacgaaga tccctatgga    660

gatatctggt taacagacaa gcaacctgag gaacacaact ttagcgatac caaaataatt    720

tccctttctc atcttgaaat gacctggact aacagaagaa attttcctgc attgcttgtg    780

aggatcttac ataaatcaaa actgcgatac tatggaaaac ctgataaaaa gatgattgaa    840

ccatatcaga cctttttgga agttgctgac agttcaggca cagtgtcagt gattatgtgg    900

aatgccctgt gtcctgagtg gtataaaagt ttgcgggttg gtttagttct tctgcttcaa    960

gactattctg ttaaaaagag ttatccattc agaatacagc ctgtccccgt ggatccacag   1020

atcaaactaa tttctacaat ggaaatctgc ctgaatcttc gagatccccc aacaaatata   1080

attatcattc cagaaaagca ggtgaaacca gaatggagac tgccaaagct aaatcaccga   1140

tttaccacaa ggtcagaact ggatgatatg ccagaaaatt gcatctgtga tgttattggc   1200

cttttagttt ttgtaggaag ggtccagcgg tcaaaaaaga aagaaaaccg tgaagatttt   1260

tggtcatatc gctggattca cattgctgac ggtacttcag aacaaccatt tatagtggaa   1320

ctgttttcaa catcgcagcc agaaatcttt gaaaatattt acccaatggc atattttgtg   1380

tgtacacagt tgaaagttgt cagaaatgac aatcaagtac ctaagctgct ttacctcacc   1440

actacaaatg agagtggagt gtttattact ggtcatagag gccagccgta tacgtatgat   1500

gccaaggtaa aaaactttat tcaatggatt agaacaaagt ctgattccgg ggaacagaag   1560

aatatggtta ttggtggata ttacccctat ccaccagtgc cagagacatt ttccaagtat   1620

agtagttcta ttaaagttga gtcgctcttg acagctataa gtgaagtcag gaaggagatt   1680

gaagacttgc agtataggga acaaaagcgc attgcaattc aggggataat tactgctata   1740

aagtatatcc cccatagcag tgcgactgaa agtgcctcag catcagaaac acttcggaat   1800

gctaacagac cctcgacctc tcaagcagct agagtagaaa tgcaagaaag aaatggtaaa   1860

cggcatcaag atgatgagcc tgtgaattct cagtatttcc aaactacatc tacaaattta   1920

agtctgagca ataaaataag aattcttcaa ggcccacacg ctaatccagt tgctgtacct   1980

caaccaggag cttctgtaca aacaaaggga attaaaccgg gcatgccaag catcttcaac   2040

cgtcgagcaa atataaatgc taatctgcaa gggaaagcca gaaaaactat aagtgatagg   2100

tgggagagtc agctgtggag agagaaaaag tttggcttaa tagatcacct acactacagc   2160

cgtgtttatc ctgaaagtat tccacggaaa tttatgtttg aacacagaaa gtttcttagt   2220

gaccagtata attctcagcc tgcgaaatat gtaccaccag aaggaaggcc cccaaaactt   2280

gatgatttta agagcgcccg aagccttgga cattttgaag taaccatact aggtctgaac   2340

catgagatag caatcgatgt tgctttccta cccatgtatt gtccagaaga tattcgaaca   2400

tctcaaatag acacactgtt gacctccatg aattacagct gtgcatatcc acaggacaca   2460

actggaaatg accgattgcc aggtccaaga gcggttgcag gtgatattat aaaagcagca   2520

actgaactgg atagagtgca tatcgtcggt atcttggata tctgtaattt gggtaataat   2580

aaagtggaag tctatttgca caagatttat agtccagaga atacttctta aaagttagca   2640

aatgaaatta ttacagatta tacgagtgta ctgctttaaa gatattccat cattttgctg   2700

gtaatttcag taactgtttt cagcaagaat attacatgag ctctaaagtt attaagcagt   2760

tttatgttcg ttttgtgttt agggagcttt ttaaaacact tcatttcaga ttcattattg   2820

aaaaaggtca tcaaaataat ttttgtgtat aagggaattt accttgctta ccttactagt   2880

atgactatta tcttgacttc tggtaattta tgttcactat tccatttgtg aagtgtactt   2940

tcattctaaa gcctcagtat aaggcatcct aacttacaag agtaactttc catggacatt   3000

taacatcctt ccaattttat tcacatataa tgggaaattt tgaattgcca gtttgaagac   3060

tgttctccta aagtgttcaa cctgcacttc ttacaaccaa ggtagtttgt atcattttca   3120

aaagtacaca ttattagggt ctagttgccc ctggtcctta gcttgctcag ctgcaaaata   3180

agcgtgctaa attaaattgt cttaaggttt ttccacttca ttttgtgact ttgtgtggtt   3240

cgaatttctc agtattttaa ccagtgtgtt gatgttaaag tcaaaggccg cagtatgtct   3300

atattcttgc tgtactcatt ggtagtttca gtatatgtaa tgtgagttta aatagtgaaa   3360

ttgtatctca tattaacatt tcaaatgctc atattgaaaa tggaaaatag taaacacagg   3420

aattgatttt attctggttg tctataatac ttcattttaa atgtaaatgg ccactctgca   3480

tttgcaaggc ccggtggttg acatctgtgt ggtttgttag atgagacaaa atgaccatta   3540

aatgagttta tagattattc tgtatcaaga taaatctgat tccagttaag ctataaactt   3600

gtgggatttt cttgtagccc tatagttctg tgacttcatt tgctatacgc tttaaatgtg   3660

ttgagcagcc tatgaaccta aagacatact gcagtttgtt cataaatgta ttcagtcttt   3720

tattctttat aattgtgtgt aaatgttaac taaacagtgg attcctctcg tgttacagtt   3780

ttgagtgaat tattaaagaa gttaaaatgc aataaaaaaa aaaaaaaaaa aaaaaaaaaa   3840

aaaaaaaaaa aaaaaaaaaa a                                             3861


<210>  4201
<211>  855
<212>  PRT
<213>  Homosapiens

<400>  4201

Met Ser Gly Glu Ser Gly Gln Pro Glu Ala Gly Pro Ser His Ala Gly 
1               5                   10                  15      


Leu Asp Trp Pro Asn Pro Glu Arg Asn Arg Ala Gly Val Pro Gly Gly 
            20                  25                  30          


Val Ile Arg Arg Ala Gly Ser Gln Gly Pro Arg Ser Trp Ile Gln Lys 
        35                  40                  45              


Val Leu Glu Gln Ile Met Asp Ser Pro Arg Gln Cys Val Thr Pro Ser 
    50                  55                  60                  


Glu Val Val Pro Val Thr Val Leu Ala Val Gln Arg Tyr Leu Leu Glu 
65                  70                  75                  80  


Asp Glu Pro Arg Asp Thr Val Pro Lys Pro Pro Leu Tyr Cys Tyr Asp 
                85                  90                  95      


Val Thr Ile Ser Asp Gly Val Tyr Gln Glu Lys Cys Tyr Leu Asp Pro 
            100                 105                 110         


Ser Leu Asn Ser Leu Val Tyr Gln Asn Ile Leu Lys Val Gly Ile Gln 
        115                 120                 125             


Met Arg Ile Ser Arg Val Ser Cys Leu Tyr Asn Glu Lys Arg Ile Gly 
    130                 135                 140                 


Gln Gly Ile Leu Cys Ile Asp Asn Val His Cys Gly Glu Thr Ser Asp 
145                 150                 155                 160 


Ser Ile Ser Leu Glu Thr Pro Phe Arg Asn Arg Ala His Gln Glu Lys 
                165                 170                 175     


Pro Glu Arg Pro Leu Arg Gly Gly Lys Ser His Tyr Leu Ala Leu Trp 
            180                 185                 190         


Asn Asn Glu Asp Pro Tyr Gly Asp Ile Trp Leu Thr Asp Lys Gln Pro 
        195                 200                 205             


Glu Glu His Asn Phe Ser Asp Thr Lys Ile Ile Ser Leu Ser His Leu 
    210                 215                 220                 


Glu Met Thr Trp Thr Asn Arg Arg Asn Phe Pro Ala Leu Leu Val Arg 
225                 230                 235                 240 


Ile Leu His Lys Ser Lys Leu Arg Tyr Tyr Gly Lys Pro Asp Lys Lys 
                245                 250                 255     


Met Ile Glu Pro Tyr Gln Thr Phe Leu Glu Val Ala Asp Ser Ser Gly 
            260                 265                 270         


Thr Val Ser Val Ile Met Trp Asn Ala Leu Cys Pro Glu Trp Tyr Lys 
        275                 280                 285             


Ser Leu Arg Val Gly Leu Val Leu Leu Leu Gln Asp Tyr Ser Val Lys 
    290                 295                 300                 


Lys Ser Tyr Pro Phe Arg Ile Gln Pro Val Pro Val Asp Pro Gln Ile 
305                 310                 315                 320 


Lys Leu Ile Ser Thr Met Glu Ile Cys Leu Asn Leu Arg Asp Pro Pro 
                325                 330                 335     


Thr Asn Ile Ile Ile Ile Pro Glu Lys Gln Val Lys Pro Glu Trp Arg 
            340                 345                 350         


Leu Pro Lys Leu Asn His Arg Phe Thr Thr Arg Ser Glu Leu Asp Asp 
        355                 360                 365             


Met Pro Glu Asn Cys Ile Cys Asp Val Ile Gly Leu Leu Val Phe Val 
    370                 375                 380                 


Gly Arg Val Gln Arg Ser Lys Lys Lys Glu Asn Arg Glu Asp Phe Trp 
385                 390                 395                 400 


Ser Tyr Arg Trp Ile His Ile Ala Asp Gly Thr Ser Glu Gln Pro Phe 
                405                 410                 415     


Ile Val Glu Leu Phe Ser Thr Ser Gln Pro Glu Ile Phe Glu Asn Ile 
            420                 425                 430         


Tyr Pro Met Ala Tyr Phe Val Cys Thr Gln Leu Lys Val Val Arg Asn 
        435                 440                 445             


Asp Asn Gln Val Pro Lys Leu Leu Tyr Leu Thr Thr Thr Asn Glu Ser 
    450                 455                 460                 


Gly Val Phe Ile Thr Gly His Arg Gly Gln Pro Tyr Thr Tyr Asp Ala 
465                 470                 475                 480 


Lys Val Lys Asn Phe Ile Gln Trp Ile Arg Thr Lys Ser Asp Ser Gly 
                485                 490                 495     


Glu Gln Lys Asn Met Val Ile Gly Gly Tyr Tyr Pro Tyr Pro Pro Val 
            500                 505                 510         


Pro Glu Thr Phe Ser Lys Tyr Ser Ser Ser Ile Lys Val Glu Ser Leu 
        515                 520                 525             


Leu Thr Ala Ile Ser Glu Val Arg Lys Glu Ile Glu Asp Leu Gln Tyr 
    530                 535                 540                 


Arg Glu Gln Lys Arg Ile Ala Ile Gln Gly Ile Ile Thr Ala Ile Lys 
545                 550                 555                 560 


Tyr Ile Pro His Ser Ser Ala Thr Glu Ser Ala Ser Ala Ser Glu Thr 
                565                 570                 575     


Leu Arg Asn Ala Asn Arg Pro Ser Thr Ser Gln Ala Ala Arg Val Glu 
            580                 585                 590         


Met Gln Glu Arg Asn Gly Lys Arg His Gln Asp Asp Glu Pro Val Asn 
        595                 600                 605             


Ser Gln Tyr Phe Gln Thr Thr Ser Thr Asn Leu Ser Leu Ser Asn Lys 
    610                 615                 620                 


Ile Arg Ile Leu Gln Gly Pro His Ala Asn Pro Val Ala Val Pro Gln 
625                 630                 635                 640 


Pro Gly Ala Ser Val Gln Thr Lys Gly Ile Lys Pro Gly Met Pro Ser 
                645                 650                 655     


Ile Phe Asn Arg Arg Ala Asn Ile Asn Ala Asn Leu Gln Gly Lys Ala 
            660                 665                 670         


Arg Lys Thr Ile Ser Asp Arg Trp Glu Ser Gln Leu Trp Arg Glu Lys 
        675                 680                 685             


Lys Phe Gly Leu Ile Asp His Leu His Tyr Ser Arg Val Tyr Pro Glu 
    690                 695                 700                 


Ser Ile Pro Arg Lys Phe Met Phe Glu His Arg Lys Phe Leu Ser Asp 
705                 710                 715                 720 


Gln Tyr Asn Ser Gln Pro Ala Lys Tyr Val Pro Pro Glu Gly Arg Pro 
                725                 730                 735     


Pro Lys Leu Asp Asp Phe Lys Ser Ala Arg Ser Leu Gly His Phe Glu 
            740                 745                 750         


Val Thr Ile Leu Gly Leu Asn His Glu Ile Ala Ile Asp Val Ala Phe 
        755                 760                 765             


Leu Pro Met Tyr Cys Pro Glu Asp Ile Arg Thr Ser Gln Ile Asp Thr 
    770                 775                 780                 


Leu Leu Thr Ser Met Asn Tyr Ser Cys Ala Tyr Pro Gln Asp Thr Thr 
785                 790                 795                 800 


Gly Asn Asp Arg Leu Pro Gly Pro Arg Ala Val Ala Gly Asp Ile Ile 
                805                 810                 815     


Lys Ala Ala Thr Glu Leu Asp Arg Val His Ile Val Gly Ile Leu Asp 
            820                 825                 830         


Ile Cys Asn Leu Gly Asn Asn Lys Val Glu Val Tyr Leu His Lys Ile 
        835                 840                 845             


Tyr Ser Pro Glu Asn Thr Ser 
    850                 855 


<210>  4202
<211>  2688
<212>  DNA
<213>  Homosapiens

<400>  4202
atagagctga tgtatccaga ggttatgttg ctagaggtga gatcagttac ctacgtgcaa     60

ctgaaatttc aaacttctgt tcagcaggga cgtgagtgga caatggtgac tgatagttgg    120

aaatatcagc aaacatctta aattttatac tcaaatgaat gagcaatgaa ccaggagaat    180

aggtccagtt ttttttggct ccttgtaatt tttacctttt tacttaaaat tacagcatct    240

ttttcaatga gtgcctatgt gactgtgact tattacaatg aaaccagcaa ctacactgca    300

atagagacat gtgaatgtgg cgtttatgga ttagcttcac cagtggctaa tgctatggga    360

gtggtaggca tccctaagaa caataactac caagcttgtg accacaacac tgagtttagt    420

aatactaaga agccctggat tgcgctgata gaaagaggta attgtacatt ttcagaaaaa    480

attcaaacag cgggcagaag aaatgctgat gctgttgtga tttacaatgc tccagagact    540

ggcaatcaga cgatacagat ggcaaatttt ggtgcagtag acattgttgc aatcatgatc    600

ggcaatctga aaggcacaaa aattctgcaa tctattcaaa gaggcataca agtgacaatg    660

gtcatagaag tagggaaaaa acatggccct tgggtgaatc actattcaat ttttttcgtt    720

tctgtgtcct tttttattat tacggcggca actgtgggct attttatctt ttattctgct    780

cgaaggctac ggaatgcaag agctcaaagc aggaagcaga ggcaattaaa ggcagatgct    840

aaaaaagcta ttggaaggct tcaactacgc acactgaaac aaggagacaa ggaaattggc    900

cctgatggag atagttgtgc tgtgtgcatt gaattgtata aaccaaatga tttggtacgc    960

atcttaacgt gcaaccatat tttccataag acatgtgttg acccatggct gttagaacac   1020

aggacttgcc ccatgtgcaa atgtgacata ctcaaagctt tgggaattga ggtggatgtt   1080

gaagatggat cagtgtcttt acaagtccct gtatccaatg aaatatctaa tagtgcctcc   1140

tcccatgaag aggataatcg cagcgagacc gcatcatctg gatatgcttc agtacaggga   1200

acagatgaac cgcctctgga ggaacacgtg cagtcaacaa atgaaagtct acagctggta   1260

aaccatgaag caaattctgt ggcagtggat gttattcctc atgttgacaa cccaaccttt   1320

gaagaagacg aaactcctaa tcaagagact gctgttcgag aaattaaatc ttaaaatctg   1380

tgtaaataga aaacttgaac cattagtaat aacagaactg ccaatcaggg cctagtttct   1440

attaataaat tggataaatt taataaaata agagtgatac tgaaagtgct cagatgacta   1500

atattatgct atagttaaat ggcttaaaat atttaacctg ttaacttttt tccacaaact   1560

cattataata tttttcatag gcaagtttcc tctcagtagt gataacaaca tttttagaca   1620

ttcaaaactg tcttcaagaa gtcacgtttt tcatttataa caattttctt ataaaaacat   1680

gttgctttta aaatgtggag tagctgtaat cactttattt tatgatagta tcttaatgaa   1740

aaatactact tctttagctt gggctacatg tgtcagggtt tttctccagg tgcttatatt   1800

gatctggaat tgtaatgtaa aaagcaatgc aaacttaggc gagtacttct tgaaatgtct   1860

atttaagctg ctttaagtta atagaaaaga ttaaagcaaa atattcattt ttactttttc   1920

ttatttttaa aattaggctg aatgtacttc atgtgatttg tcaaccatag tttatcagag   1980

attatggact taattgattg gtatattagt gacatcaact tgacacaaga ttagacaaaa   2040

aattccttac aaaaatactg tgtaactatt tctcaaactt gtgggatttt tcaaaagctc   2100

agtatatgaa tcatcatact gtttgaaatt gctaatgaca gagtaagtaa cactaatatt   2160

ggtcattgat cttcgttcat gaattagtct acagaaaaaa aatgttctgt aaaattagtc   2220

tgttgaaaat gttttccaaa caatgttact ttgaaaattg agtttatgtt tgacctaaat   2280

gggctaaaat tacattagat aaactaaaat tctgtccgtg taactataaa ttttgtgaat   2340

gcattttcct ggtgtttgaa aaagaagggg gggagaattc caggtgcctt aatataaagt   2400

ttgaagcttc atccaccaaa gttaaataga gctatttaaa aatgcacttt atttgtactc   2460

tgtgtggctt ttgttttaga attttgttca aattatagca gaatttaggc aaaaataaaa   2520

cagacatgta tttttgtttg ctgaatggat gaaaccattg cattcttgta cactgatttg   2580

aaatgctgta aatatgtccc aatttgtatt gattctcttt aaatataaaa tgtaaataaa   2640

atattccaat aaaagtttgt gtctggtgtt agtttaaaaa aaaaaaaa                2688


<210>  4203
<211>  402
<212>  PRT
<213>  Homosapiens

<400>  4203

Met Asn Gln Glu Asn Arg Ser Ser Phe Phe Trp Leu Leu Val Ile Phe 
1               5                   10                  15      


Thr Phe Leu Leu Lys Ile Thr Ala Ser Phe Ser Met Ser Ala Tyr Val 
            20                  25                  30          


Thr Val Thr Tyr Tyr Asn Glu Thr Ser Asn Tyr Thr Ala Ile Glu Thr 
        35                  40                  45              


Cys Glu Cys Gly Val Tyr Gly Leu Ala Ser Pro Val Ala Asn Ala Met 
    50                  55                  60                  


Gly Val Val Gly Ile Pro Lys Asn Asn Asn Tyr Gln Ala Cys Asp His 
65                  70                  75                  80  


Asn Thr Glu Phe Ser Asn Thr Lys Lys Pro Trp Ile Ala Leu Ile Glu 
                85                  90                  95      


Arg Gly Asn Cys Thr Phe Ser Glu Lys Ile Gln Thr Ala Gly Arg Arg 
            100                 105                 110         


Asn Ala Asp Ala Val Val Ile Tyr Asn Ala Pro Glu Thr Gly Asn Gln 
        115                 120                 125             


Thr Ile Gln Met Ala Asn Phe Gly Ala Val Asp Ile Val Ala Ile Met 
    130                 135                 140                 


Ile Gly Asn Leu Lys Gly Thr Lys Ile Leu Gln Ser Ile Gln Arg Gly 
145                 150                 155                 160 


Ile Gln Val Thr Met Val Ile Glu Val Gly Lys Lys His Gly Pro Trp 
                165                 170                 175     


Val Asn His Tyr Ser Ile Phe Phe Val Ser Val Ser Phe Phe Ile Ile 
            180                 185                 190         


Thr Ala Ala Thr Val Gly Tyr Phe Ile Phe Tyr Ser Ala Arg Arg Leu 
        195                 200                 205             


Arg Asn Ala Arg Ala Gln Ser Arg Lys Gln Arg Gln Leu Lys Ala Asp 
    210                 215                 220                 


Ala Lys Lys Ala Ile Gly Arg Leu Gln Leu Arg Thr Leu Lys Gln Gly 
225                 230                 235                 240 


Asp Lys Glu Ile Gly Pro Asp Gly Asp Ser Cys Ala Val Cys Ile Glu 
                245                 250                 255     


Leu Tyr Lys Pro Asn Asp Leu Val Arg Ile Leu Thr Cys Asn His Ile 
            260                 265                 270         


Phe His Lys Thr Cys Val Asp Pro Trp Leu Leu Glu His Arg Thr Cys 
        275                 280                 285             


Pro Met Cys Lys Cys Asp Ile Leu Lys Ala Leu Gly Ile Glu Val Asp 
    290                 295                 300                 


Val Glu Asp Gly Ser Val Ser Leu Gln Val Pro Val Ser Asn Glu Ile 
305                 310                 315                 320 


Ser Asn Ser Ala Ser Ser His Glu Glu Asp Asn Arg Ser Glu Thr Ala 
                325                 330                 335     


Ser Ser Gly Tyr Ala Ser Val Gln Gly Thr Asp Glu Pro Pro Leu Glu 
            340                 345                 350         


Glu His Val Gln Ser Thr Asn Glu Ser Leu Gln Leu Val Asn His Glu 
        355                 360                 365             


Ala Asn Ser Val Ala Val Asp Val Ile Pro His Val Asp Asn Pro Thr 
    370                 375                 380                 


Phe Glu Glu Asp Glu Thr Pro Asn Gln Glu Thr Ala Val Arg Glu Ile 
385                 390                 395                 400 


Lys Ser 
        


<210>  4204
<211>  2851
<212>  DNA
<213>  Homosapiens

<400>  4204
gcttcacgct aaagccccag agcccgacgc ggcagccgcg gtagcggaga agactggagc     60

tccgaggagc tgcatctgcg gcaacctgtg tgctgacgct acgtgcctcc tggctccgac    120

gtagctcgca gctccccagt ctcactccat tccttcccca cctggcgcgc acctgctcaa    180

gaccagggtc ctgccaagcg ctaggagggc gcgtgccagg ggcgctaggg aactgcggag    240

cgcgcgcgcc atggggccgc cgcctggggc cggggtctcc tgccgcggtg gctgcggctt    300

ttccagattg ctggcatggt gcttcctgct ggccctgagt ccgcaggcac ccggttcccg    360

gggggctgaa gcagtgtgga ccgcgtacct caacgtgtcc tggcgggttc cgcacacggg    420

agtgaaccgt acggtgtggg agctgagcga ggagggcgtg tacggccagg actcgccgct    480

ggagcctgtg gctggggtcc tggtaccgcc cgacgggccc ggggcgctta acgcctgtaa    540

cccgcacacg aatttcacgg tgcccacggt ttggggaagc accgtgcaag tctcttggtt    600

ggccctcatc caacgcggcg ggggctgcac cttcgcagac aagatccatc tggcttatga    660

gagaggggcg tctggagccg tcatctttaa cttccccggg acccgcaatg aggtcatccc    720

catgtctcac ccgggtgcag tagacattgt tgcaatcatg atcggcaatc tgaaaggcac    780

aaaaattctg caatctattc aaagaggcat acaagtgaca atggtcatag aagtagggaa    840

aaaacatggc ccttgggtga atcactattc aatttttttc gtttctgtgt ccttttttat    900

tattacggcg gcaactgtgg gctattttat cttttattct gctcgaaggc tacggaatgc    960

aagagctcaa agcaggaagc agaggcaatt aaaggcagat gctaaaaaag ctattggaag   1020

gcttcaacta cgcacactga aacaaggaga caaggaaatt ggccctgatg gagatagttg   1080

tgctgtgtgc attgaattgt ataaaccaaa tgatttggta cgcatcttaa cgtgcaacca   1140

tattttccat aagacatgtg ttgacccatg gctgttagaa cacaggactt gccccatgtg   1200

caaatgtgac atactcaaag ctttgggaat tgaggtggat gttgaagatg gatcagtgtc   1260

tttacaagtc cctgtatcca atgaaatatc taatagtgcc tcctcccatg aagaggataa   1320

tcgcagcgag accgcatcat ctggatatgc ttcagtacag ggaacagatg aaccgcctct   1380

ggaggaacac gtgcagtcaa caaatgaaag tctacagctg gtaaaccatg aagcaaattc   1440

tgtggcagtg gatgttattc ctcatgttga caacccaacc tttgaagaag acgaaactcc   1500

taatcaagag actgctgttc gagaaattaa atcttaaaat ctgtgtaaat agaaaacttg   1560

aaccattagt aataacagaa ctgccaatca gggcctagtt tctattaata aattggataa   1620

atttaataaa ataagagtga tactgaaagt gctcagatga ctaatattat gctatagtta   1680

aatggcttaa aatatttaac ctgttaactt ttttccacaa actcattata atatttttca   1740

taggcaagtt tcctctcagt agtgataaca acatttttag acattcaaaa ctgtcttcaa   1800

gaagtcacgt ttttcattta taacaatttt cttataaaaa catgttgctt ttaaaatgtg   1860

gagtagctgt aatcacttta ttttatgata gtatcttaat gaaaaatact acttctttag   1920

cttgggctac atgtgtcagg gtttttctcc aggtgcttat attgatctgg aattgtaatg   1980

taaaaagcaa tgcaaactta ggcgagtact tcttgaaatg tctatttaag ctgctttaag   2040

ttaatagaaa agattaaagc aaaatattca tttttacttt ttcttatttt taaaattagg   2100

ctgaatgtac ttcatgtgat ttgtcaacca tagtttatca gagattatgg acttaattga   2160

ttggtatatt agtgacatca acttgacaca agattagaca aaaaattcct tacaaaaata   2220

ctgtgtaact atttctcaaa cttgtgggat ttttcaaaag ctcagtatat gaatcatcat   2280

actgtttgaa attgctaatg acagagtaag taacactaat attggtcatt gatcttcgtt   2340

catgaattag tctacagaaa aaaaatgttc tgtaaaatta gtctgttgaa aatgttttcc   2400

aaacaatgtt actttgaaaa ttgagtttat gtttgaccta aatgggctaa aattacatta   2460

gataaactaa aattctgtcc gtgtaactat aaattttgtg aatgcatttt cctggtgttt   2520

gaaaaagaag ggggggagaa ttccaggtgc cttaatataa agtttgaagc ttcatccacc   2580

aaagttaaat agagctattt aaaaatgcac tttatttgta ctctgtgtgg cttttgtttt   2640

agaattttgt tcaaattata gcagaattta ggcaaaaata aaacagacat gtatttttgt   2700

ttgctgaatg gatgaaacca ttgcattctt gtacactgat ttgaaatgct gtaaatatgt   2760

cccaatttgt attgattctc tttaaatata aaatgtaaat aaaatattcc aataaaagtt   2820

tgtgtctggt gttagtttaa aaaaaaaaaa a                                  2851


<210>  4205
<211>  428
<212>  PRT
<213>  Homosapiens

<400>  4205

Met Gly Pro Pro Pro Gly Ala Gly Val Ser Cys Arg Gly Gly Cys Gly 
1               5                   10                  15      


Phe Ser Arg Leu Leu Ala Trp Cys Phe Leu Leu Ala Leu Ser Pro Gln 
            20                  25                  30          


Ala Pro Gly Ser Arg Gly Ala Glu Ala Val Trp Thr Ala Tyr Leu Asn 
        35                  40                  45              


Val Ser Trp Arg Val Pro His Thr Gly Val Asn Arg Thr Val Trp Glu 
    50                  55                  60                  


Leu Ser Glu Glu Gly Val Tyr Gly Gln Asp Ser Pro Leu Glu Pro Val 
65                  70                  75                  80  


Ala Gly Val Leu Val Pro Pro Asp Gly Pro Gly Ala Leu Asn Ala Cys 
                85                  90                  95      


Asn Pro His Thr Asn Phe Thr Val Pro Thr Val Trp Gly Ser Thr Val 
            100                 105                 110         


Gln Val Ser Trp Leu Ala Leu Ile Gln Arg Gly Gly Gly Cys Thr Phe 
        115                 120                 125             


Ala Asp Lys Ile His Leu Ala Tyr Glu Arg Gly Ala Ser Gly Ala Val 
    130                 135                 140                 


Ile Phe Asn Phe Pro Gly Thr Arg Asn Glu Val Ile Pro Met Ser His 
145                 150                 155                 160 


Pro Gly Ala Val Asp Ile Val Ala Ile Met Ile Gly Asn Leu Lys Gly 
                165                 170                 175     


Thr Lys Ile Leu Gln Ser Ile Gln Arg Gly Ile Gln Val Thr Met Val 
            180                 185                 190         


Ile Glu Val Gly Lys Lys His Gly Pro Trp Val Asn His Tyr Ser Ile 
        195                 200                 205             


Phe Phe Val Ser Val Ser Phe Phe Ile Ile Thr Ala Ala Thr Val Gly 
    210                 215                 220                 


Tyr Phe Ile Phe Tyr Ser Ala Arg Arg Leu Arg Asn Ala Arg Ala Gln 
225                 230                 235                 240 


Ser Arg Lys Gln Arg Gln Leu Lys Ala Asp Ala Lys Lys Ala Ile Gly 
                245                 250                 255     


Arg Leu Gln Leu Arg Thr Leu Lys Gln Gly Asp Lys Glu Ile Gly Pro 
            260                 265                 270         


Asp Gly Asp Ser Cys Ala Val Cys Ile Glu Leu Tyr Lys Pro Asn Asp 
        275                 280                 285             


Leu Val Arg Ile Leu Thr Cys Asn His Ile Phe His Lys Thr Cys Val 
    290                 295                 300                 


Asp Pro Trp Leu Leu Glu His Arg Thr Cys Pro Met Cys Lys Cys Asp 
305                 310                 315                 320 


Ile Leu Lys Ala Leu Gly Ile Glu Val Asp Val Glu Asp Gly Ser Val 
                325                 330                 335     


Ser Leu Gln Val Pro Val Ser Asn Glu Ile Ser Asn Ser Ala Ser Ser 
            340                 345                 350         


His Glu Glu Asp Asn Arg Ser Glu Thr Ala Ser Ser Gly Tyr Ala Ser 
        355                 360                 365             


Val Gln Gly Thr Asp Glu Pro Pro Leu Glu Glu His Val Gln Ser Thr 
    370                 375                 380                 


Asn Glu Ser Leu Gln Leu Val Asn His Glu Ala Asn Ser Val Ala Val 
385                 390                 395                 400 


Asp Val Ile Pro His Val Asp Asn Pro Thr Phe Glu Glu Asp Glu Thr 
                405                 410                 415     


Pro Asn Gln Glu Thr Ala Val Arg Glu Ile Lys Ser 
            420                 425             


<210>  4206
<211>  5726
<212>  DNA
<213>  Homosapiens

<400>  4206
acgtgggaga gaagggaggg ttgggggaag tgtggaaaac ctgaacctga gctgctgtcg     60

cctgaggaag atttggtggg aggagaagca gaggggaaga gacgggttga gagtgaggtg    120

aggagggcat ctaggtcact gctcccgggg ggcacaaagt tcgcgatgtg gctgaagcct    180

gaggaagtgc ttctgaaaaa tgcgctgaag ctgtggctga tggaaaggtc caacgactac    240

ttcgtgctgc agcggcgtcg gggctacggg gaggaaggcg gaggggggct cacagggctt    300

ctggttggga ctcttgattc agtcttggac tctactgcta aagtagctcc atttcgcatc    360

ctacaccaga caccagattc tcaagtttac ttgtcaattg catgtggagc caacagagaa    420

gaaataacca agcattggga ttggttggaa caaaatatta tgaagacctt atctgtattt    480

gattcaaatg aagatattac taattttgta caaggaaaaa taagaggatt aattgctgaa    540

gagggaaaac attgttttgc aaaagaagat gatcctgaga aatttcgaga agcccttttg    600

aaatttgaaa aatgttttgg tttaccagag aaggagaagt tagtgaccta ttattcatgc    660

agttattgga aaggacgggt tccttgtcag ggttggcttt atcttagcac caactttctg    720

agcttctatt cttttttgtt gggatcagaa ataaaactca ttatctcctg ggatgaagtc    780

tcaaaacttg aaaagacttc aaatgtcata ctgacagaga gtattcacgt gtgttcccaa    840

ggagagaatc actacttttc aatgtttttg cacattaacc aaacatacct tcttatggaa    900

cagctggcaa actatgccat tagaagactt tttgataagg aaacatttga taatgaccca    960

gtcctttata atcctctaca gatcaccaaa agaggtctgg aaaatagagc ccacagtgag   1020

caatttaatg ccttttttag gctgcccaaa ggagagagtt tgaaagaagt acatgaatgt   1080

ttcttatggg taccattcag ccacttcaat actcatggga aaatgtgcat ctcagaaaat   1140

tatatctgct ttgctagcca agatggcaat cagtgtagtg taatcattcc actacgagag   1200

gtcttagcta tagataagac aaatgattcc agcaaatctg tcatcattag catcaaagga   1260

aaaacagctt ttcgcttcca tgaagttaaa gactttgaac aactggtagc aaaactcagg   1320

ctcagatgcg gagcagcttc aactcaatat catgatatta gcacagagct tgctattagt   1380

tctgagtcta cagagccatc tgataatttt gaggtgcaat ctttgacaag tcagagggaa   1440

tgcagtaaaa ctgtgaacac tgaagcctta atgacagtat ttcaccctca gaatttggag   1500

actcttaatt ctaaaatgtt gaaagaaaaa atgaaggaac agtcatggaa aatactgttt   1560

gcagaatgtg gacgtggtgt tagtatgttt cgaaccaaaa agactcgaga tcttgttgta   1620

agagggattc cagaaacatt aagaggagaa ctctggatgc ttttttcagg tgctgttaat   1680

gacatggcta ctaatcctga ctattatact gaagtggttg agcagtcctt agggacctgc   1740

aacttggcta ctgaagaaat tgaacgtgat ttacgtcgct ctctgcctga gcacccagcc   1800

tttcagagtg atactggcat atctgctctg agaagggtac tcacagctta tgcatacagg   1860

aatcccaaaa ttggatactg ccaggcaatg aatattttga cttcagtgct gcttctatat   1920

gcaaaagagg aagaagcttt ttggcttctg gttgctgtat gtgaacgaat gttgcctgat   1980

tattttaatc gtcgaattat tggtgccttg gtggatcagg cagtctttga agaacttatc   2040

agggatcacc ttcctcagct gacagaacac atgactgata tgacattctt ttcctcagtt   2100

tctctctctt ggtttctcac actttttatt agtgtgctac ctattgaaag tgcagtgaat   2160

gtggtggact gtttcttcta tgatggaata aaggccattt tgcaactggg attggcaata   2220

cttgactata atttagacaa actgctgact tgtaaagatg atgctgaagc tgtgacagcc   2280

ttaaacaggt tctttgacaa tgtcactaat aaggatagtc cattgccttc aaatgttcag   2340

caaggttcaa atgtgagtga tgaaaaaacc agtcatacta gagtggatat tacagatttg   2400

attagagaat caaatgagaa atatggtaat attcgctatg aagatataca tagtatgcgc   2460

tgtcgaaata ggttgtatgt gatacagacc ctagaggaaa caacaaaaca gaatgtgttg   2520

cgtgttgtat cacaagatgt gaaattgagc cttcaagaat tggatgaact ttatgtcatc   2580

tttaagaaag agctgttttt atcttgttat tggtgtttgg gttgcccagt attgaagcat   2640

catgacccca gtctgccata tttggaacag tatcagattg actgccagca gttcagagcg   2700

ttgtatcact tgttgagtcc ctgggctcat tctgcaaata aagactcact agctttatgg   2760

acattcagat tgttagatga aaactctgat tgccttataa acttcaaaga attctcctct   2820

gcaattgaca taatgtacaa tggaagtttt actgagaagc ttaagctgct ttttaagcta   2880

catattcctc cagcttacac tgaagtgaaa tctaaggatg cttcaaaagg agatgaactt   2940

tccaaggaag aattacttta tttcagtcag ctgcatgttt ccaagcctgc aaatgagaag   3000

gaagcagaat cagcaaaaca cagccctgaa aaaggcaaag ggaaaattga tattcaagca   3060

tatctaagtc aatggcaaga tgagcttttc aaaaaagaag aaaacattaa ggatttacca   3120

agaatgaatc agtctcagtt tattcagttt tcaaagaccc tctataactt atttcatgag   3180

gaccctgaag aagaatcatt atatcaagcc attgctgttg taaccagcct tttactcagg   3240

atggaagaag ttggaaggaa actacatagc cctacatcat cagccaaagg attctctggt   3300

actgtctgtg gttctggagg acccagtgag gaaaaaacag ggagccactt ggagaaagat   3360

ccttgttcct ttagggagga acctcagtgg tcatttgcat ttgaacagat tcttgcatcg   3420

ctgttgaatg aaccagcatt ggtgaggttt tttgagaaac ccatagatgt aaaagccaag   3480

ctggaaaatg caagaatttc tcagttaagg tctagaacca agatgtaaat ccctaggaat   3540

tgcctatcat agacaagttt actaacattc ctgtagctgt cagtttgatt cctgtgagta   3600

gggctcaggg atttatcttg ttaccaatgt gtctgaaggc caaaatatat atccagaagc   3660

acaatgcatc attcctttgt tgttgataat gggctttgtt agcacttttt aaaacaaaca   3720

aacaaacaaa acaaaaaagc aaaccacatt tgttatctca aattttgatg atattctcaa   3780

atacaaatat acttttttat atttcacaat atatgcaata tcaggggaat atgctaaatg   3840

ttaccaccag agggcacaag catatcactt ttagtaagga aattactagc ttgtgttgct   3900

atttacatat gaattactga ttattttgaa aagacggtgt tatgcttggg tgttagtgag   3960

gctgatatgt catgtcaatc gataaaccct actttccaaa ttatctaaaa gattaccatt   4020

tggggccctt gttttcaagt tatctaactg aaatattatt aattttttta agttaatctc   4080

attcagtctt ctagtaataa atgctttttt aagtaccttc tacagtcttc ctacctgagg   4140

ggttcagagg ctgctgactc acactgctaa ctctgttact gacaaaagca aatcaataac   4200

tctaaattct gggctgatat aaagaaaaaa acaatattgg atttggattt aatctgggta   4260

aaatcagcct tctgagaagg gctaagaaac agttcaatta actgtatagg tctttcatta   4320

gaccgagaca tcactagaaa ttctgggcac tgctgtttgt ggtatttgtc tcagagtagc   4380

ttatgactgt tttggttcta gctttagatt ttggattttc accagtcatg tgttaattta   4440

cattagatag taaagaatgg ctacactaag actgaattat cttattagtc tggcaagcat   4500

ataaagtata cttgtatgta atgattgcca aggtaacaga attgctgaca tctgtctaaa   4560

aagttttgac tatccaattt agatgtgtaa tttctatata ctttatgctg tttatatttc   4620

agtcattaca ccaagtccat ttagagataa tgggctttgt tagcactttc aaaaaaaaaa   4680

aaagcaaacc atacttgtcc actgtcctgt gctattccta ccaaggacaa tttattaatc   4740

aattgactta gaaaataggg ggagaaatca ttcattggag cttctttctt tagaaaagac   4800

tttggttata agccttttga cttttctaga tgtgaaacca tgaaagggca gacctccttc   4860

agagtgactc aagaggtctc cctttcttgg agggagttgg tacagtcagc ctttgggaag   4920

aatccactgt gaacaaagct taacacatgg ggcttcatcg ctcatagaat atgttatttt   4980

caaagaagtt caagaatttt caagttgagc ctttgaaaat cccataaatt ggttttagct   5040

aaacacttac tagtagtgtc tttaaattat ttaatcaacc ttgtcttttc aaggaaatta   5100

ccacttaaag agatagttgg taaataaaca tctatgcctt ttctcagaaa tgatttgctg   5160

aactatgtcc atattttaca gcttagataa tagtttatat ggaaactatt atacatctgc   5220

tattgtgcaa tgattgttaa attatactga agtagctcta gaaagacaca tgtatacaag   5280

gcactattgt acacactttg ctgaatattt tgtcagttgt atttacaaag aaaggtactt   5340

tcttaagagc atatatgtta ttaatatttg atatgatttt aaagtcagaa tagtacagat   5400

tgctgagtat tatactttag gctagattaa ttaaaattga atactgaaag agattttttg   5460

agttgcaaaa agtttataaa tgcaaagcaa aaagaaaaca tttattttct gagtctgcag   5520

gagaaacaaa ctaaacatta tagttttata gctgctatct tgttaaccaa acaggttgtt   5580

cataatatta aaaatcttac gtagttgtgt taaactgaac cagttcatta taccttatgc   5640

attaaattaa atatgttata aggtggcttt acttgtcttt ataaaaataa atatatctac   5700

taaacatgaa aaaaaaaaaa aaaaaa                                        5726


<210>  4207
<211>  1120
<212>  PRT
<213>  Homosapiens

<400>  4207

Met Trp Leu Lys Pro Glu Glu Val Leu Leu Lys Asn Ala Leu Lys Leu 
1               5                   10                  15      


Trp Leu Met Glu Arg Ser Asn Asp Tyr Phe Val Leu Gln Arg Arg Arg 
            20                  25                  30          


Gly Tyr Gly Glu Glu Gly Gly Gly Gly Leu Thr Gly Leu Leu Val Gly 
        35                  40                  45              


Thr Leu Asp Ser Val Leu Asp Ser Thr Ala Lys Val Ala Pro Phe Arg 
    50                  55                  60                  


Ile Leu His Gln Thr Pro Asp Ser Gln Val Tyr Leu Ser Ile Ala Cys 
65                  70                  75                  80  


Gly Ala Asn Arg Glu Glu Ile Thr Lys His Trp Asp Trp Leu Glu Gln 
                85                  90                  95      


Asn Ile Met Lys Thr Leu Ser Val Phe Asp Ser Asn Glu Asp Ile Thr 
            100                 105                 110         


Asn Phe Val Gln Gly Lys Ile Arg Gly Leu Ile Ala Glu Glu Gly Lys 
        115                 120                 125             


His Cys Phe Ala Lys Glu Asp Asp Pro Glu Lys Phe Arg Glu Ala Leu 
    130                 135                 140                 


Leu Lys Phe Glu Lys Cys Phe Gly Leu Pro Glu Lys Glu Lys Leu Val 
145                 150                 155                 160 


Thr Tyr Tyr Ser Cys Ser Tyr Trp Lys Gly Arg Val Pro Cys Gln Gly 
                165                 170                 175     


Trp Leu Tyr Leu Ser Thr Asn Phe Leu Ser Phe Tyr Ser Phe Leu Leu 
            180                 185                 190         


Gly Ser Glu Ile Lys Leu Ile Ile Ser Trp Asp Glu Val Ser Lys Leu 
        195                 200                 205             


Glu Lys Thr Ser Asn Val Ile Leu Thr Glu Ser Ile His Val Cys Ser 
    210                 215                 220                 


Gln Gly Glu Asn His Tyr Phe Ser Met Phe Leu His Ile Asn Gln Thr 
225                 230                 235                 240 


Tyr Leu Leu Met Glu Gln Leu Ala Asn Tyr Ala Ile Arg Arg Leu Phe 
                245                 250                 255     


Asp Lys Glu Thr Phe Asp Asn Asp Pro Val Leu Tyr Asn Pro Leu Gln 
            260                 265                 270         


Ile Thr Lys Arg Gly Leu Glu Asn Arg Ala His Ser Glu Gln Phe Asn 
        275                 280                 285             


Ala Phe Phe Arg Leu Pro Lys Gly Glu Ser Leu Lys Glu Val His Glu 
    290                 295                 300                 


Cys Phe Leu Trp Val Pro Phe Ser His Phe Asn Thr His Gly Lys Met 
305                 310                 315                 320 


Cys Ile Ser Glu Asn Tyr Ile Cys Phe Ala Ser Gln Asp Gly Asn Gln 
                325                 330                 335     


Cys Ser Val Ile Ile Pro Leu Arg Glu Val Leu Ala Ile Asp Lys Thr 
            340                 345                 350         


Asn Asp Ser Ser Lys Ser Val Ile Ile Ser Ile Lys Gly Lys Thr Ala 
        355                 360                 365             


Phe Arg Phe His Glu Val Lys Asp Phe Glu Gln Leu Val Ala Lys Leu 
    370                 375                 380                 


Arg Leu Arg Cys Gly Ala Ala Ser Thr Gln Tyr His Asp Ile Ser Thr 
385                 390                 395                 400 


Glu Leu Ala Ile Ser Ser Glu Ser Thr Glu Pro Ser Asp Asn Phe Glu 
                405                 410                 415     


Val Gln Ser Leu Thr Ser Gln Arg Glu Cys Ser Lys Thr Val Asn Thr 
            420                 425                 430         


Glu Ala Leu Met Thr Val Phe His Pro Gln Asn Leu Glu Thr Leu Asn 
        435                 440                 445             


Ser Lys Met Leu Lys Glu Lys Met Lys Glu Gln Ser Trp Lys Ile Leu 
    450                 455                 460                 


Phe Ala Glu Cys Gly Arg Gly Val Ser Met Phe Arg Thr Lys Lys Thr 
465                 470                 475                 480 


Arg Asp Leu Val Val Arg Gly Ile Pro Glu Thr Leu Arg Gly Glu Leu 
                485                 490                 495     


Trp Met Leu Phe Ser Gly Ala Val Asn Asp Met Ala Thr Asn Pro Asp 
            500                 505                 510         


Tyr Tyr Thr Glu Val Val Glu Gln Ser Leu Gly Thr Cys Asn Leu Ala 
        515                 520                 525             


Thr Glu Glu Ile Glu Arg Asp Leu Arg Arg Ser Leu Pro Glu His Pro 
    530                 535                 540                 


Ala Phe Gln Ser Asp Thr Gly Ile Ser Ala Leu Arg Arg Val Leu Thr 
545                 550                 555                 560 


Ala Tyr Ala Tyr Arg Asn Pro Lys Ile Gly Tyr Cys Gln Ala Met Asn 
                565                 570                 575     


Ile Leu Thr Ser Val Leu Leu Leu Tyr Ala Lys Glu Glu Glu Ala Phe 
            580                 585                 590         


Trp Leu Leu Val Ala Val Cys Glu Arg Met Leu Pro Asp Tyr Phe Asn 
        595                 600                 605             


Arg Arg Ile Ile Gly Ala Leu Val Asp Gln Ala Val Phe Glu Glu Leu 
    610                 615                 620                 


Ile Arg Asp His Leu Pro Gln Leu Thr Glu His Met Thr Asp Met Thr 
625                 630                 635                 640 


Phe Phe Ser Ser Val Ser Leu Ser Trp Phe Leu Thr Leu Phe Ile Ser 
                645                 650                 655     


Val Leu Pro Ile Glu Ser Ala Val Asn Val Val Asp Cys Phe Phe Tyr 
            660                 665                 670         


Asp Gly Ile Lys Ala Ile Leu Gln Leu Gly Leu Ala Ile Leu Asp Tyr 
        675                 680                 685             


Asn Leu Asp Lys Leu Leu Thr Cys Lys Asp Asp Ala Glu Ala Val Thr 
    690                 695                 700                 


Ala Leu Asn Arg Phe Phe Asp Asn Val Thr Asn Lys Asp Ser Pro Leu 
705                 710                 715                 720 


Pro Ser Asn Val Gln Gln Gly Ser Asn Val Ser Asp Glu Lys Thr Ser 
                725                 730                 735     


His Thr Arg Val Asp Ile Thr Asp Leu Ile Arg Glu Ser Asn Glu Lys 
            740                 745                 750         


Tyr Gly Asn Ile Arg Tyr Glu Asp Ile His Ser Met Arg Cys Arg Asn 
        755                 760                 765             


Arg Leu Tyr Val Ile Gln Thr Leu Glu Glu Thr Thr Lys Gln Asn Val 
    770                 775                 780                 


Leu Arg Val Val Ser Gln Asp Val Lys Leu Ser Leu Gln Glu Leu Asp 
785                 790                 795                 800 


Glu Leu Tyr Val Ile Phe Lys Lys Glu Leu Phe Leu Ser Cys Tyr Trp 
                805                 810                 815     


Cys Leu Gly Cys Pro Val Leu Lys His His Asp Pro Ser Leu Pro Tyr 
            820                 825                 830         


Leu Glu Gln Tyr Gln Ile Asp Cys Gln Gln Phe Arg Ala Leu Tyr His 
        835                 840                 845             


Leu Leu Ser Pro Trp Ala His Ser Ala Asn Lys Asp Ser Leu Ala Leu 
    850                 855                 860                 


Trp Thr Phe Arg Leu Leu Asp Glu Asn Ser Asp Cys Leu Ile Asn Phe 
865                 870                 875                 880 


Lys Glu Phe Ser Ser Ala Ile Asp Ile Met Tyr Asn Gly Ser Phe Thr 
                885                 890                 895     


Glu Lys Leu Lys Leu Leu Phe Lys Leu His Ile Pro Pro Ala Tyr Thr 
            900                 905                 910         


Glu Val Lys Ser Lys Asp Ala Ser Lys Gly Asp Glu Leu Ser Lys Glu 
        915                 920                 925             


Glu Leu Leu Tyr Phe Ser Gln Leu His Val Ser Lys Pro Ala Asn Glu 
    930                 935                 940                 


Lys Glu Ala Glu Ser Ala Lys His Ser Pro Glu Lys Gly Lys Gly Lys 
945                 950                 955                 960 


Ile Asp Ile Gln Ala Tyr Leu Ser Gln Trp Gln Asp Glu Leu Phe Lys 
                965                 970                 975     


Lys Glu Glu Asn Ile Lys Asp Leu Pro Arg Met Asn Gln Ser Gln Phe 
            980                 985                 990         


Ile Gln Phe Ser Lys Thr Leu Tyr  Asn Leu Phe His Glu  Asp Pro Glu 
        995                 1000                 1005             


Glu Glu  Ser Leu Tyr Gln Ala  Ile Ala Val Val Thr  Ser Leu Leu 
    1010                 1015                 1020             


Leu Arg  Met Glu Glu Val Gly  Arg Lys Leu His Ser  Pro Thr Ser 
    1025                 1030                 1035             


Ser Ala  Lys Gly Phe Ser Gly  Thr Val Cys Gly Ser  Gly Gly Pro 
    1040                 1045                 1050             


Ser Glu  Glu Lys Thr Gly Ser  His Leu Glu Lys Asp  Pro Cys Ser 
    1055                 1060                 1065             


Phe Arg  Glu Glu Pro Gln Trp  Ser Phe Ala Phe Glu  Gln Ile Leu 
    1070                 1075                 1080             


Ala Ser  Leu Leu Asn Glu Pro  Ala Leu Val Arg Phe  Phe Glu Lys 
    1085                 1090                 1095             


Pro Ile  Asp Val Lys Ala Lys  Leu Glu Asn Ala Arg  Ile Ser Gln 
    1100                 1105                 1110             


Leu Arg  Ser Arg Thr Lys Met  
    1115                 1120 


<210>  4208
<211>  2607
<212>  DNA
<213>  Homosapiens

<400>  4208
acgtgggaga gaagggaggg ttgggggaag tgtggaaaac ctgaacctga gctgctgtcg     60

cctgaggaag atttggtggg aggagaagca gaggggaaga gacgggttga gagtgaggtg    120

aggagggcat ctaggtcact gctcccgggg ggcacaaagt tcgcgatgtg gctgaagcct    180

gaggaagtgc ttctgaaaaa tgcgctgaag ctgtggctga tggaaaggtc caacgactac    240

ttcgtgctgc agcggcgtcg gggctacggg gaggaaggcg gaggggggct cacagggctt    300

ctggttggga ctcttgattc agtcttggac tctactgcta aagtagctcc atttcgcatc    360

ctacaccaga caccagattc tcaagtttac ttgtcaattg catgtggagc caacagagaa    420

gaaataacca agcattggga ttggttggaa caaaatatta tgaagacctt atctgtattt    480

gattcaaatg aagatattac taattttgta caaggaaaaa taagaggatt aattgctgaa    540

gagggaaaac attgttttgc aaaagaagat gatcctgaga aatttcgaga agcccttttg    600

aaatttgaaa aatgttttgg tttaccagag aaggagaagt tagtgaccta ttattcatgc    660

agttattgga aaggacgggt tccttgtcag ggttggcttt atcttagcac caactttctg    720

agcttctatt cttttttgtt gggatcagaa ataaaactca ttatctcctg ggatgaagtc    780

tcaaaacttg aaaagacttc aaatgtcata ctgacagaga gtattcacgt gtgttcccaa    840

ggagagaatc actacttttc aatgtttttg cacattaacc aaacatacct tcttatggaa    900

cagctggcaa actatgccat tagaagactt tttgataagg aaacatttga taatgaccca    960

gtcctttata atcctctaca gatcaccaaa agaggtctgg aaaatagagc ccacagtgag   1020

caatttaatg ccttttttag gctgcccaaa ggagagagtt tgaaagaagt acatgaatgt   1080

ttcttatggg taccattcag ccacttcaat actcatggga aaatgtgcat ctcagaaaat   1140

tatatctgct ttgctagcca agatggcaat cagtgtagtg taatcattcc actacgagag   1200

gtcttagcta tagataagac aaatgattcc agcaaatctg tcatcattag catcaaagga   1260

aaaacagctt ttcgcttcca tgaagttaaa gactttgaac aactggtagc aaaactcagg   1320

ctcagatgcg gagcagcttc aactcaatat catgatatta gcacagagct tgctattagt   1380

tctgagtcta cagagccatc tgataatttt gaggtgcaat ctttgacaag tcagagggaa   1440

tgcagtaaaa ctgtgaacac tgaagcctta atgacagtat ttcaccctca gaatttggag   1500

actcttaatt ctaaaatgtt gaaagaaaaa atgaaggaac agtcatggaa aatactgttt   1560

gcagaatgtg gacgtggtgt tagtatgttt cgaaccaaaa agactcgaga tcttgttgta   1620

agagggattc cagaaacatt aagaggagaa ctctggatgc ttttttcagg tgctgttaat   1680

gacatggcta ctaatcctga ctattatact gaagtggttg agcagtcctt agggacctgc   1740

aacttggcta ctgaagaaat tgaacgtgat ttacgtcgct ctctgcctga gcacccagcc   1800

tttcagagtg atactggcat atctgctctg agaagggtac tcacagctta tgcatacagg   1860

aatcccaaaa ttggatactg ccaggcaatg aatattttga cttcagtgct gcttctatat   1920

gcaaaagagg aagaagcttt ttggcttctg gttgctgtat gtgaacgaat gttgcctgat   1980

tattttaatc gtcgaattat tggttcagat gattttatgc cactagtaag aatccaagga   2040

caatgtgtta ttggggagaa gtagaaaaag gaaaatctgg ggtagcacct ggcatgctct   2100

ttctccaatt ttctactact tactcctatt ccccaaattc tcccatcaag gaggaaatga   2160

actctgagac agaagatgag ttttcctcaa agcttgacca ggatataagt ggatgcctta   2220

ttgggcaaag cagagggtaa ccaattagaa ggccctggct tctcttgatt gatagctgag   2280

aactcatcag agggatcagt gctttctctg tgtattgctg gagtctgaaa gtgtgactct   2340

catgtcactg attcatttct gaagtgttaa attcagaata aatttttgat aatcaaaatg   2400

aacttagaga actttgttgt ttggcattgt caagagtgaa gaattctaat tatttgtgta   2460

tttatcttgt gttatgctag atattaaact ccctgaacat gagactattt cattaattgg   2520

tatagctctt ataataccta gtacaggtct ctgcatataa taaagactca ataaataact   2580

cttcaaatga aaaaaaaaaa aaaaaaa                                       2607


<210>  4209
<211>  632
<212>  PRT
<213>  Homosapiens

<400>  4209

Met Trp Leu Lys Pro Glu Glu Val Leu Leu Lys Asn Ala Leu Lys Leu 
1               5                   10                  15      


Trp Leu Met Glu Arg Ser Asn Asp Tyr Phe Val Leu Gln Arg Arg Arg 
            20                  25                  30          


Gly Tyr Gly Glu Glu Gly Gly Gly Gly Leu Thr Gly Leu Leu Val Gly 
        35                  40                  45              


Thr Leu Asp Ser Val Leu Asp Ser Thr Ala Lys Val Ala Pro Phe Arg 
    50                  55                  60                  


Ile Leu His Gln Thr Pro Asp Ser Gln Val Tyr Leu Ser Ile Ala Cys 
65                  70                  75                  80  


Gly Ala Asn Arg Glu Glu Ile Thr Lys His Trp Asp Trp Leu Glu Gln 
                85                  90                  95      


Asn Ile Met Lys Thr Leu Ser Val Phe Asp Ser Asn Glu Asp Ile Thr 
            100                 105                 110         


Asn Phe Val Gln Gly Lys Ile Arg Gly Leu Ile Ala Glu Glu Gly Lys 
        115                 120                 125             


His Cys Phe Ala Lys Glu Asp Asp Pro Glu Lys Phe Arg Glu Ala Leu 
    130                 135                 140                 


Leu Lys Phe Glu Lys Cys Phe Gly Leu Pro Glu Lys Glu Lys Leu Val 
145                 150                 155                 160 


Thr Tyr Tyr Ser Cys Ser Tyr Trp Lys Gly Arg Val Pro Cys Gln Gly 
                165                 170                 175     


Trp Leu Tyr Leu Ser Thr Asn Phe Leu Ser Phe Tyr Ser Phe Leu Leu 
            180                 185                 190         


Gly Ser Glu Ile Lys Leu Ile Ile Ser Trp Asp Glu Val Ser Lys Leu 
        195                 200                 205             


Glu Lys Thr Ser Asn Val Ile Leu Thr Glu Ser Ile His Val Cys Ser 
    210                 215                 220                 


Gln Gly Glu Asn His Tyr Phe Ser Met Phe Leu His Ile Asn Gln Thr 
225                 230                 235                 240 


Tyr Leu Leu Met Glu Gln Leu Ala Asn Tyr Ala Ile Arg Arg Leu Phe 
                245                 250                 255     


Asp Lys Glu Thr Phe Asp Asn Asp Pro Val Leu Tyr Asn Pro Leu Gln 
            260                 265                 270         


Ile Thr Lys Arg Gly Leu Glu Asn Arg Ala His Ser Glu Gln Phe Asn 
        275                 280                 285             


Ala Phe Phe Arg Leu Pro Lys Gly Glu Ser Leu Lys Glu Val His Glu 
    290                 295                 300                 


Cys Phe Leu Trp Val Pro Phe Ser His Phe Asn Thr His Gly Lys Met 
305                 310                 315                 320 


Cys Ile Ser Glu Asn Tyr Ile Cys Phe Ala Ser Gln Asp Gly Asn Gln 
                325                 330                 335     


Cys Ser Val Ile Ile Pro Leu Arg Glu Val Leu Ala Ile Asp Lys Thr 
            340                 345                 350         


Asn Asp Ser Ser Lys Ser Val Ile Ile Ser Ile Lys Gly Lys Thr Ala 
        355                 360                 365             


Phe Arg Phe His Glu Val Lys Asp Phe Glu Gln Leu Val Ala Lys Leu 
    370                 375                 380                 


Arg Leu Arg Cys Gly Ala Ala Ser Thr Gln Tyr His Asp Ile Ser Thr 
385                 390                 395                 400 


Glu Leu Ala Ile Ser Ser Glu Ser Thr Glu Pro Ser Asp Asn Phe Glu 
                405                 410                 415     


Val Gln Ser Leu Thr Ser Gln Arg Glu Cys Ser Lys Thr Val Asn Thr 
            420                 425                 430         


Glu Ala Leu Met Thr Val Phe His Pro Gln Asn Leu Glu Thr Leu Asn 
        435                 440                 445             


Ser Lys Met Leu Lys Glu Lys Met Lys Glu Gln Ser Trp Lys Ile Leu 
    450                 455                 460                 


Phe Ala Glu Cys Gly Arg Gly Val Ser Met Phe Arg Thr Lys Lys Thr 
465                 470                 475                 480 


Arg Asp Leu Val Val Arg Gly Ile Pro Glu Thr Leu Arg Gly Glu Leu 
                485                 490                 495     


Trp Met Leu Phe Ser Gly Ala Val Asn Asp Met Ala Thr Asn Pro Asp 
            500                 505                 510         


Tyr Tyr Thr Glu Val Val Glu Gln Ser Leu Gly Thr Cys Asn Leu Ala 
        515                 520                 525             


Thr Glu Glu Ile Glu Arg Asp Leu Arg Arg Ser Leu Pro Glu His Pro 
    530                 535                 540                 


Ala Phe Gln Ser Asp Thr Gly Ile Ser Ala Leu Arg Arg Val Leu Thr 
545                 550                 555                 560 


Ala Tyr Ala Tyr Arg Asn Pro Lys Ile Gly Tyr Cys Gln Ala Met Asn 
                565                 570                 575     


Ile Leu Thr Ser Val Leu Leu Leu Tyr Ala Lys Glu Glu Glu Ala Phe 
            580                 585                 590         


Trp Leu Leu Val Ala Val Cys Glu Arg Met Leu Pro Asp Tyr Phe Asn 
        595                 600                 605             


Arg Arg Ile Ile Gly Ser Asp Asp Phe Met Pro Leu Val Arg Ile Gln 
    610                 615                 620                 


Gly Gln Cys Val Ile Gly Glu Lys 
625                 630         


<210>  4210
<211>  1174
<212>  DNA
<213>  Homosapiens

<400>  4210
gggaagtagg agaccccact ggctttggtc ccctaagaat ggactctgct gcctgtgctg     60

ctgctgccac ccctgttcca gccctggctt tggccctagc tccagaccta gcacaagccc    120

cactggcact ccctggcctg ttaagcccat cttgccttct ctcctctgga caagaagtaa    180

atgggagtga aagaggaact tgtctctgga ggccctggct gtcttccaca aatgactccc    240

caaggcagat gaggaagctg gtggatttgg ctgctggtgg ggcaacggct gctgaggtca    300

ccaaggctga atccaagttc catcaccctg tcaggctctt ctggcctaaa tcccgctcct    360

tcgactatct gtacagtgct ggggagattt tactgcagaa ctttcctgtc caggcaacca    420

tcaacctata cgaggactca gacagcgaag aagaagagga agatgaagag caggaggatg    480

aagaagagaa gtaggaggcc aatgaaaagg ggccagaagg gtgtgtgagg gtaccagggt    540

ccatacccta cagcgccaca gctcatcccc cttcctcacc cctaacctat ccaaatggag    600

gcagccagag tctgattggg gttcagtttg tctggcaagt tttcacagac atcagttagc    660

cggaagtatt agtccagcag atagagcttt ctggactgaa aattgggtca tctagctgcc    720

cagctcaccc tggcttacct gaatggcctg tgagctcagg cctcttgcat ctcattgtct    780

gggctgctgt tgtgttgacc atgggagggt tctaggagct ctagaaggaa ggcttgctga    840

agcccccagg aagcagagca gggcagggaa tgcccttgtg gagggaagta gtcattcctc    900

aggccctttg actccctagc cttcccaggt ggccatgtag tcccgtctct ctgtggaaag    960

cctgacttct ggcttcaccc caaggaatac caacagcaga tccatgcaag gttggggtgc   1020

ctttttgatg agtcttacag gaagggaagg cagtgtgtag agaatcggct tgctctgggg   1080

atgcctcccc attttgcctg ctgtccattg aagtctgtgt gttggcatga gatgaatcag   1140

gagaaaaata aactggatgg tgttttcctt tttc                               1174


<210>  4211
<211>  151
<212>  PRT
<213>  Homosapiens

<400>  4211

Met Asp Ser Ala Ala Cys Ala Ala Ala Ala Thr Pro Val Pro Ala Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ala Pro Asp Leu Ala Gln Ala Pro Leu Ala Leu Pro 
            20                  25                  30          


Gly Leu Leu Ser Pro Ser Cys Leu Leu Ser Ser Gly Gln Glu Val Asn 
        35                  40                  45              


Gly Ser Glu Arg Gly Thr Cys Leu Trp Arg Pro Trp Leu Ser Ser Thr 
    50                  55                  60                  


Asn Asp Ser Pro Arg Gln Met Arg Lys Leu Val Asp Leu Ala Ala Gly 
65                  70                  75                  80  


Gly Ala Thr Ala Ala Glu Val Thr Lys Ala Glu Ser Lys Phe His His 
                85                  90                  95      


Pro Val Arg Leu Phe Trp Pro Lys Ser Arg Ser Phe Asp Tyr Leu Tyr 
            100                 105                 110         


Ser Ala Gly Glu Ile Leu Leu Gln Asn Phe Pro Val Gln Ala Thr Ile 
        115                 120                 125             


Asn Leu Tyr Glu Asp Ser Asp Ser Glu Glu Glu Glu Glu Asp Glu Glu 
    130                 135                 140                 


Gln Glu Asp Glu Glu Glu Lys 
145                 150     


<210>  4212
<211>  1030
<212>  DNA
<213>  Homosapiens

<400>  4212
ttctgggaag taggagaccc cactggcttt ggtcccctaa gaatggactc tgctgcctgt     60

gctgctgctg ccacccctgt tccagccctg gctttggccc tagctccaga cctagcacaa    120

gccccactgg cactccctgg cctgttaagc ccatcttgcc ttctctcctc tggacaagaa    180

gtaaatggga gtgaaaggct cttctggcct aaatcccgct ccttcgacta tctgtacagt    240

gctggggaga ttttactgca gaactttcct gtccaggcaa ccatcaacct atacgaggac    300

tcagacagcg aagaagaaga ggaagatgaa gagcaggagg atgaagaaga gaagtaggag    360

gccaatgaaa aggggccaga agggtgtgtg agggtaccag ggtccatacc ctacagcgcc    420

acagctcatc ccccttcctc acccctaacc tatccaaatg gaggcagcca gagtctgatt    480

ggggttcagt ttgtctggca agttttcaca gacatcagtt agccggaagt attagtccag    540

cagatagagc tttctggact gaaaattggg tcatctagct gcccagctca ccctggctta    600

cctgaatggc ctgtgagctc aggcctcttg catctcattg tctgggctgc tgttgtgttg    660

accatgggag ggttctagga gctctagaag gaaggcttgc tgaagccccc aggaagcaga    720

gcagggcagg gaatgccctt gtggagggaa gtagtcattc ctcaggccct ttgactccct    780

agccttccca ggtggccatg tagtcccgtc tctctgtgga aagcctgact tctggcttca    840

ccccaaggaa taccaacagc agatccatgc aaggttgggg tgcctttttg atgagtctta    900

caggaaggga aggcagtgtg tagagaatcg gcttgctctg gggatgcctc cccattttgc    960

ctgctgtcca ttgaagtctg tgtgttggca tgagatgaat caggagaaaa ataaactgga   1020

tggtgttttc                                                          1030


<210>  4213
<211>  104
<212>  PRT
<213>  Homosapiens

<400>  4213

Met Asp Ser Ala Ala Cys Ala Ala Ala Ala Thr Pro Val Pro Ala Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ala Pro Asp Leu Ala Gln Ala Pro Leu Ala Leu Pro 
            20                  25                  30          


Gly Leu Leu Ser Pro Ser Cys Leu Leu Ser Ser Gly Gln Glu Val Asn 
        35                  40                  45              


Gly Ser Glu Arg Leu Phe Trp Pro Lys Ser Arg Ser Phe Asp Tyr Leu 
    50                  55                  60                  


Tyr Ser Ala Gly Glu Ile Leu Leu Gln Asn Phe Pro Val Gln Ala Thr 
65                  70                  75                  80  


Ile Asn Leu Tyr Glu Asp Ser Asp Ser Glu Glu Glu Glu Glu Asp Glu 
                85                  90                  95      


Glu Gln Glu Asp Glu Glu Glu Lys 
            100                 


<210>  4214
<211>  2959
<212>  DNA
<213>  Homosapiens

<400>  4214
agatggattt tgcaaagctg tggttaacga ttagaaatcc tttatcacct cagcccgtgg     60

ccccttgtac ttcgctcccc tccctcagga tccctttctc cctctccagg ggcatctccc    120

cctccaaggc tctgcaaaga actgccctgt cttctagatg ccttcttgag gctgcttgtg    180

gccacccaca gacacttgta aggaggagag aagtcagcct ggcagagaga ctctgaaatg    240

agggattaga ggtgttcaag gagcaagagc ttcagcctga agacaaggga gcagtccctg    300

aagacgcttc tactgagagg tctgccatgg cctctcttgg cctccaactt gtgggctaca    360

tcctaggcct tctggggctt ttgggcacac tggttgccat gctgctcccc agctggaaaa    420

caagttctta tgtcggtgcc agcattgtga cagcagttgg cttctccaag ggcctctgga    480

tggaatgtgc cacacacagc acaggcatca cccagtgtga catctatagc acccttctgg    540

gcctgcccgc tgacatccag gctgcccagg ccatgatggt gacatccagt gcaatctcct    600

ccctggcctg cattatctct gtggtgggca tgagatgcac agtcttctgc caggaatccc    660

gagccaaaga cagagtggcg gtagcaggtg gagtcttttt catccttgga ggcctcctgg    720

gattcattcc tgttgcctgg aatcttcatg ggatcctacg ggacttctac tcaccactgg    780

tgcctgacag catgaaattt gagattggag aggctcttta cttgggcatt atttcttccc    840

tgttctccct gatagctgga atcatcctct gcttttcctg ctcatcccag agaaatcgct    900

ccaactacta cgatgcctac caagcccaac ctcttgccac aaggagctct ccaaggcctg    960

gtcaacctcc caaagtcaag agtgagttca attcctacag cctgacaggg tatgtgtgaa   1020

gaaccagggg ccagagctgg ggggtggctg ggtctgtgaa aaacagtgga cagcaccccg   1080

agggccacag gtgagggaca ctaccactgg atcgtgtcag aaggtgctgc tgaggataga   1140

ctgactttgg ccattggatt gagcaaaggc agaaatgggg gctagtgtaa cagcatgcag   1200

gttgaattgc caaggatgct cgccatgcca gcctttctgt tttcctcacc ttgctgctcc   1260

cctgccctaa gtccccaacc ctcaacttga aaccccattc ccttaagcca ggactcagag   1320

gatccctttg ccctctggtt tacctgggac tccatcccca aacccactaa tcacatccca   1380

ctgactgacc ctctgtgatc aaagaccctc tctctggctg aggttggctc ttagctcatt   1440

gctggggatg ggaaggagaa gcagtggctt ttgtgggcat tgctctaacc tacttctcaa   1500

gcttccctcc aaagaaactg attggccctg gaacctccat cccactcttg ttatgactcc   1560

acagtgtcca gactaatttg tgcatgaact gaaataaaac catcctacgg tatccaggga   1620

acagaaagca ggatgcagga tgggaggaca ggaaggcagc ctgggacatt taaaaaaata   1680

aaaatgaaaa aaaaacccag aacccatttc tcagggcact ttccagaatt ctctcatatt   1740

tgtgggctgg gatcaagcct gcagcttgag gaaagcacaa ggaaaggaaa gaagatctgg   1800

tggaaagctc aggtggcagc ggactctgac tccactgagg aactgcctca gaagctgcga   1860

tcacaacttt ggctgaagcc cctgcctcac tctagggcac ctgacctggc ctcttgccta   1920

aaccacaagg ctaagggcta tagacaatgg tttccttagg aacagtaaac cagtttttct   1980

agggatggcc cttggctggg ggatgacagt gtgggagctg tggggtactg aggaagacac   2040

cattccttga cggtgtctaa gaagccaggt ggatgtgtgt ggtggctcca gtgggtgttt   2100

ctactctgcc agtgagaggc agccccctag aaactcttca ggcgtaatgg aaaatcagct   2160

caaatgagat caggcccccc cagggtccac ccacagagca ctacagagcc tctgaaagac   2220

catagcacca agcgagcccc ttcagattcc cccactgtcc atcggaagat gctccagagt   2280

ggctagaggg catctaaggg ctccagcatg gcatatccat gcccacggtg ctgtgtccat   2340

gatctgagtg atagctgcac tgctgcctgg gattgcagct gaggtgggag tggagaatgg   2400

ttcccaggaa gacagttcca cctctaaggt ccgaaaatgt tccctttacc ctggagtggg   2460

agtgaggggt catacaccaa aggtattttc cctcaccagt ctaggcatga ctggcttctg   2520

aaaaattcca gcacacctcc tcgaacctca ttgtcagcag agagggccca tctgttgtct   2580

gtaacatgcc tttcacatgt ccaccttctt gccatgttcc agctgctctc ccaacctgga   2640

aggccgtctc cccttagcca agtcctcctc aggcttggag aacttcctca gcgtcacctc   2700

cttcattgag ccttctctga tcactccatc cctctcctac ccctccctcc cccaaccctc   2760

aatgtataaa ttgcttcttg atgcttagca ttcacaattt ttgattgatc gttatttgtg   2820

tgtgtgtgtc cgatctcaca agtatattgt aaacccttcg gtgggtgggg gccatatcct   2880

agacctctct gtatccccca gactatctgt aacagtgcca ggcacacagt aggtgatcaa   2940

taaacacttg ttgattgag                                                2959


<210>  4215
<211>  230
<212>  PRT
<213>  Homosapiens

<400>  4215

Met Ala Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu 
1               5                   10                  15      


Gly Leu Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr 
            20                  25                  30          


Ser Ser Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys 
    50                  55                  60                  


Asp Ile Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala 
65                  70                  75                  80  


Gln Ala Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile 
                85                  90                  95      


Ile Ser Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg 
            100                 105                 110         


Ala Lys Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly 
        115                 120                 125             


Gly Leu Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu 
    130                 135                 140                 


Arg Asp Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Glu Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile 
                165                 170                 175     


Ala Gly Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser 
            180                 185                 190         


Asn Tyr Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser 
        195                 200                 205             


Pro Arg Pro Gly Gln Pro Pro Lys Val Lys Ser Glu Phe Asn Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Gly Tyr Val 
225                 230 


<210>  4216
<211>  3037
<212>  DNA
<213>  Homosapiens

<400>  4216
aaccagcaaa acaaaaaaat gattattacc gaggattcat tgcccagcct agaagccatc     60

ttgaactatt ccattttcaa ccgtgaaaat gacctgctgg cccagtttga tgccatccca    120

ggcaaaaaag gcactcgtgt tctcatttgg aacatccgca gaaataaaaa tggaaaatct    180

gagttggact ttgatacaga tcaatatgac atcctggttt cagactttga cacagaagaa    240

aaaatgactg gcggtgttac ctctgagcta ccagaaacag aatattcttt aagggcattt    300

tgtggtattc tatacatgaa gccacgcatg aaaatttttc tgcgtcaaaa gaaggtgact    360

acccagatga ttgccaagag cctggccaat gtagaatatg atacacataa acctaccttc    420

acaaataagc aggtgagaat cacctttggg ttctcttgca agaatagtaa ccagtttgga    480

ataatgatgt atcataacaa ccgactcata aaatcttttg agaaggtggg gtgccaggtg    540

aagccaactc gtggagaagg tgtaggagta attggagtca ttgagtgcaa tttcctaaaa    600

cctgcctaca acaaacaaga ctttgagtat accaaggagt accggctaac aataaatgcc    660

cttgcccaga agctcaatgc ttactggaag gaaaaaacat ctcaagataa ttttgagacc    720

tcaactgtag ccaggccaat accgaaggtt cctgaccaga catgggttca gtgtgatgag    780

tgtcttaaat ggagaaagct tcctgggaag attgatccat ccatgttacc tgcaagatgg    840

ttttgttatt ataattccca tccaaagtac aggagatgct ctgttccaga ggaacaagaa    900

ctcattgatg aagacctgtg cttgagcaaa gctaagaaac aagaacaaac tgttgaggag    960

aagaagaaga tgcctatgga aaatgagaac caccaggtat tcagtaatcc accaaagatc   1020

ctcactgttc aagaaatggc tggattgaat aacaagacaa ttggatatga gggaattcat   1080

agccctagtg tgcttccttc tggtggagaa gaaagcagat caccatctct tcaacttaag   1140

cctctggatt ccagtgtttt acagttttcc agtaagtaca aatggatcct aggtgaagaa   1200

ccggtggaga aacgaagaag gctccagaat gagatgacaa caccttctct agattattcc   1260

atgcctgctc cttacaggag ggtagaagca cctgttgcct acccagaagg ggagaacagc   1320

catgataaat cgagttctga gagaagtaca ccaccatacc ttttcccaga atacccagaa   1380

gcaagcaaga atacaggtca gaatagggag gtttcaattc tgtatccagg ggccaaagac   1440

caacgccagg ggtccctgct tcctgaagaa ttagaagatc agatgccaag attggtggca   1500

gaagaatcta acagaggtag cacaaccata aacaaagaag aagtcaacaa gggacctttt   1560

gtagctgttg tgggtgttgc caaaggtgtt agagattcag gagctcccat tcagctgatc   1620

ccttttaaca gagaggagct tgctgagaga cgaaaagcag ttgaatcctg gaacccagtg   1680

ccttattctg tggcctctgc tgcaatccct gctgcagcca ttggggagaa agcaagaggc   1740

tatgaggaga gcgaaggtca taatacacca aagttgaaga accagagaga gctggaagaa   1800

ttgaagagaa ccacagaaaa attggaacgt gttttggctg aaaggaattt gttccagcaa   1860

aaggtggagg agctggaaca ggagaggaat cactggcagt ctgaattcaa gaaagtccaa   1920

catgaattgg tgatctacag tacccaggag gcggaaggct tgtactggag caagaaacac   1980

atgggttatc gccaagctga attccagatt ctgaaagctg agctggaaag aaccaaagag   2040

gaaaagcaag agttaaaaga gaaactgaag gaaacagaga cacacctgga aatgctgcag   2100

aaggctcagg tctcctaccg gaccccagag ggagatgacc tagaaagggc tttggcaaag   2160

cttacgcggc tacgtatcca cgtcagctat ctccttactt ctgtcctccc tcacttggag   2220

cttcgtgaga tcgggtatga ctcagaacaa gtggatggga tcctgtacac ggtgctggag   2280

gcaaatcaca tactggattg agcaccagac tgtataccct tctcttctct tatcttctgt   2340

ctgttctctt ttctctccct ccctcacgtc tctctctctc tctctctctc tctctctctc   2400

tctcaccctc acctttatgc cttatataga gaatctctgt gtaaatcctg gctcataatc   2460

agtctccttt ttatcagttt tggtgtggag aaagaggcca gtttaaatag gctttcaaga   2520

gtctagggtc agaaaagcaa tagtcactaa gctaggtgac ctgaaagctt taattttcat   2580

gacctggata tgtggtctat tgtatatctt tttctgaaat ggtttgtatt catttaggtt   2640

agatcaatca gcagatattg ggtccggtat accaggtatt attttggggt aagctaacaa   2700

gtacaactca tgtttgcagc cttcgaagat gtaacaatct cgttggaaac ataagacata   2760

catcacatta tacacaaaag tgtatgatat gtacaactga gtggtacaga tatgacatgg   2820

aagatctggg ggaggaagtt caaggaaggc accacaccag aaatgggacc taaattaagg   2880

cttaaagaat gagcatggcc acactgtcag tgagtgttct ttaggtggta ggactatggt   2940

tgatattttt cttcttccta tcttcctgcc tttttcagat tttcaatatt aaacttgtta   3000

ttcttacatt ggaaaaaaat aaattgtttt taaaaag                            3037


<210>  4217
<211>  760
<212>  PRT
<213>  Homosapiens

<400>  4217

Met Ile Ile Thr Glu Asp Ser Leu Pro Ser Leu Glu Ala Ile Leu Asn 
1               5                   10                  15      


Tyr Ser Ile Phe Asn Arg Glu Asn Asp Leu Leu Ala Gln Phe Asp Ala 
            20                  25                  30          


Ile Pro Gly Lys Lys Gly Thr Arg Val Leu Ile Trp Asn Ile Arg Arg 
        35                  40                  45              


Asn Lys Asn Gly Lys Ser Glu Leu Asp Phe Asp Thr Asp Gln Tyr Asp 
    50                  55                  60                  


Ile Leu Val Ser Asp Phe Asp Thr Glu Glu Lys Met Thr Gly Gly Val 
65                  70                  75                  80  


Thr Ser Glu Leu Pro Glu Thr Glu Tyr Ser Leu Arg Ala Phe Cys Gly 
                85                  90                  95      


Ile Leu Tyr Met Lys Pro Arg Met Lys Ile Phe Leu Arg Gln Lys Lys 
            100                 105                 110         


Val Thr Thr Gln Met Ile Ala Lys Ser Leu Ala Asn Val Glu Tyr Asp 
        115                 120                 125             


Thr His Lys Pro Thr Phe Thr Asn Lys Gln Val Arg Ile Thr Phe Gly 
    130                 135                 140                 


Phe Ser Cys Lys Asn Ser Asn Gln Phe Gly Ile Met Met Tyr His Asn 
145                 150                 155                 160 


Asn Arg Leu Ile Lys Ser Phe Glu Lys Val Gly Cys Gln Val Lys Pro 
                165                 170                 175     


Thr Arg Gly Glu Gly Val Gly Val Ile Gly Val Ile Glu Cys Asn Phe 
            180                 185                 190         


Leu Lys Pro Ala Tyr Asn Lys Gln Asp Phe Glu Tyr Thr Lys Glu Tyr 
        195                 200                 205             


Arg Leu Thr Ile Asn Ala Leu Ala Gln Lys Leu Asn Ala Tyr Trp Lys 
    210                 215                 220                 


Glu Lys Thr Ser Gln Asp Asn Phe Glu Thr Ser Thr Val Ala Arg Pro 
225                 230                 235                 240 


Ile Pro Lys Val Pro Asp Gln Thr Trp Val Gln Cys Asp Glu Cys Leu 
                245                 250                 255     


Lys Trp Arg Lys Leu Pro Gly Lys Ile Asp Pro Ser Met Leu Pro Ala 
            260                 265                 270         


Arg Trp Phe Cys Tyr Tyr Asn Ser His Pro Lys Tyr Arg Arg Cys Ser 
        275                 280                 285             


Val Pro Glu Glu Gln Glu Leu Ile Asp Glu Asp Leu Cys Leu Ser Lys 
    290                 295                 300                 


Ala Lys Lys Gln Glu Gln Thr Val Glu Glu Lys Lys Lys Met Pro Met 
305                 310                 315                 320 


Glu Asn Glu Asn His Gln Val Phe Ser Asn Pro Pro Lys Ile Leu Thr 
                325                 330                 335     


Val Gln Glu Met Ala Gly Leu Asn Asn Lys Thr Ile Gly Tyr Glu Gly 
            340                 345                 350         


Ile His Ser Pro Ser Val Leu Pro Ser Gly Gly Glu Glu Ser Arg Ser 
        355                 360                 365             


Pro Ser Leu Gln Leu Lys Pro Leu Asp Ser Ser Val Leu Gln Phe Ser 
    370                 375                 380                 


Ser Lys Tyr Lys Trp Ile Leu Gly Glu Glu Pro Val Glu Lys Arg Arg 
385                 390                 395                 400 


Arg Leu Gln Asn Glu Met Thr Thr Pro Ser Leu Asp Tyr Ser Met Pro 
                405                 410                 415     


Ala Pro Tyr Arg Arg Val Glu Ala Pro Val Ala Tyr Pro Glu Gly Glu 
            420                 425                 430         


Asn Ser His Asp Lys Ser Ser Ser Glu Arg Ser Thr Pro Pro Tyr Leu 
        435                 440                 445             


Phe Pro Glu Tyr Pro Glu Ala Ser Lys Asn Thr Gly Gln Asn Arg Glu 
    450                 455                 460                 


Val Ser Ile Leu Tyr Pro Gly Ala Lys Asp Gln Arg Gln Gly Ser Leu 
465                 470                 475                 480 


Leu Pro Glu Glu Leu Glu Asp Gln Met Pro Arg Leu Val Ala Glu Glu 
                485                 490                 495     


Ser Asn Arg Gly Ser Thr Thr Ile Asn Lys Glu Glu Val Asn Lys Gly 
            500                 505                 510         


Pro Phe Val Ala Val Val Gly Val Ala Lys Gly Val Arg Asp Ser Gly 
        515                 520                 525             


Ala Pro Ile Gln Leu Ile Pro Phe Asn Arg Glu Glu Leu Ala Glu Arg 
    530                 535                 540                 


Arg Lys Ala Val Glu Ser Trp Asn Pro Val Pro Tyr Ser Val Ala Ser 
545                 550                 555                 560 


Ala Ala Ile Pro Ala Ala Ala Ile Gly Glu Lys Ala Arg Gly Tyr Glu 
                565                 570                 575     


Glu Ser Glu Gly His Asn Thr Pro Lys Leu Lys Asn Gln Arg Glu Leu 
            580                 585                 590         


Glu Glu Leu Lys Arg Thr Thr Glu Lys Leu Glu Arg Val Leu Ala Glu 
        595                 600                 605             


Arg Asn Leu Phe Gln Gln Lys Val Glu Glu Leu Glu Gln Glu Arg Asn 
    610                 615                 620                 


His Trp Gln Ser Glu Phe Lys Lys Val Gln His Glu Leu Val Ile Tyr 
625                 630                 635                 640 


Ser Thr Gln Glu Ala Glu Gly Leu Tyr Trp Ser Lys Lys His Met Gly 
                645                 650                 655     


Tyr Arg Gln Ala Glu Phe Gln Ile Leu Lys Ala Glu Leu Glu Arg Thr 
            660                 665                 670         


Lys Glu Glu Lys Gln Glu Leu Lys Glu Lys Leu Lys Glu Thr Glu Thr 
        675                 680                 685             


His Leu Glu Met Leu Gln Lys Ala Gln Val Ser Tyr Arg Thr Pro Glu 
    690                 695                 700                 


Gly Asp Asp Leu Glu Arg Ala Leu Ala Lys Leu Thr Arg Leu Arg Ile 
705                 710                 715                 720 


His Val Ser Tyr Leu Leu Thr Ser Val Leu Pro His Leu Glu Leu Arg 
                725                 730                 735     


Glu Ile Gly Tyr Asp Ser Glu Gln Val Asp Gly Ile Leu Tyr Thr Val 
            740                 745                 750         


Leu Glu Ala Asn His Ile Leu Asp 
        755                 760 


<210>  4218
<211>  1689
<212>  DNA
<213>  Homosapiens

<400>  4218
acccaagttg gaggtagggg cctgtggaaa catgaagagg gtaaacagct gtgtgaagag     60

tgatgagcat gtcctggagg agctggaaac agaaggggag aggcagctga aaagcctcct    120

tcagcatcaa cttgatactt ctgtctccat tgaggaatgt atgtctaaga aagagagctt    180

tgctcctggt actatgtaca agccctttgg gaaggaagca gctgggacta tgactttgtc    240

ccaattccag acactgcatg agaaggacca ggaaactgct tctctcaggg aattagggct    300

taatgaaaca gaaatcttga tctggaagag ccatgtttct ggtgaaaaga agacaaaact    360

gagggcaact cctgaagcaa tacagaaccg tcttcaagat attgaagaaa ggatctcgga    420

gcgtcagcgc attctttgcc tgccacagag atttgcaaag agcaaacagc tgacccggcg    480

agaaatggaa atagaaaagt ctttatttca gggagctgat cgtcactcct tccttaaggc    540

tctttattac caagatgaac cccaaaagaa gaacaaaggt gatcccatga acaacctgga    600

aagtttttac caagagatga taatgaaaaa acgtcttgaa gagtttcaac ttatgagagg    660

tgaacccttt gcttcccact cactggtctc agctacatca gtgggtgata gtggcacagc    720

tgagagccca tcattactcc aggacaaggg aaaacaggca gcacagggta aaggccccag    780

tctccatgtg gcaaatgtta ttgatttttc acctgagcag tgttggactg ggcctaagaa    840

gctgacgcag ccaatagaat ttgtcccaga agatgaaatc cagagaaatc gtttgtcaga    900

ggaagagatc cgaaaaattc ctatgttttc ttcatataat ccaggggaac caaacaaggt    960

attatacctg aagaacctta gccctcgggt gactgaaaga gatcttgtgt cattgttcgc   1020

tcggttccag gagaaaaaag gacctccaat tcaattccga atgatgactg gacgaatgag   1080

gggccaggcc tttatcacct ttcccaataa ggagatagca tggcaagcat tgcatctagt   1140

aaatggatac aaactatatg ggaaaatatt ggtgatagag tttggaaaga acaaaaagca   1200

acggtcaaat ctccaagcga cttctctcat atcatgtgct acaggtagca ctacagaaat   1260

tagtggtagc tagaatatat ataaattgtg ggtcctggat ggtctttctt gaattggaat   1320

cttggatcta ggatttatgt atagacacca gtttgtttgg agttgaagag gaaaaactaa   1380

ctgagggagg ggaaaaaagt aatttcagct tttggagaga actggtagaa aacattttct   1440

attatataat tgaagactat ataggacaga tgatatgctg agtatgaagg gtaaagtgca   1500

aagagtatta ttttctcagg atgaattaca acggattatt cctaaggatt tttaaaaatc   1560

tttataattt ttctggggtc ctcaatattt gtctctagag ataacattct ttcttagact   1620

gcttcgtata cacagaaata aaaaactaat taaatgttga aaaaaaaaaa aaaaaaaaaa   1680

aaaaaaaaa                                                           1689


<210>  4219
<211>  413
<212>  PRT
<213>  Homosapiens

<400>  4219

Met Lys Arg Val Asn Ser Cys Val Lys Ser Asp Glu His Val Leu Glu 
1               5                   10                  15      


Glu Leu Glu Thr Glu Gly Glu Arg Gln Leu Lys Ser Leu Leu Gln His 
            20                  25                  30          


Gln Leu Asp Thr Ser Val Ser Ile Glu Glu Cys Met Ser Lys Lys Glu 
        35                  40                  45              


Ser Phe Ala Pro Gly Thr Met Tyr Lys Pro Phe Gly Lys Glu Ala Ala 
    50                  55                  60                  


Gly Thr Met Thr Leu Ser Gln Phe Gln Thr Leu His Glu Lys Asp Gln 
65                  70                  75                  80  


Glu Thr Ala Ser Leu Arg Glu Leu Gly Leu Asn Glu Thr Glu Ile Leu 
                85                  90                  95      


Ile Trp Lys Ser His Val Ser Gly Glu Lys Lys Thr Lys Leu Arg Ala 
            100                 105                 110         


Thr Pro Glu Ala Ile Gln Asn Arg Leu Gln Asp Ile Glu Glu Arg Ile 
        115                 120                 125             


Ser Glu Arg Gln Arg Ile Leu Cys Leu Pro Gln Arg Phe Ala Lys Ser 
    130                 135                 140                 


Lys Gln Leu Thr Arg Arg Glu Met Glu Ile Glu Lys Ser Leu Phe Gln 
145                 150                 155                 160 


Gly Ala Asp Arg His Ser Phe Leu Lys Ala Leu Tyr Tyr Gln Asp Glu 
                165                 170                 175     


Pro Gln Lys Lys Asn Lys Gly Asp Pro Met Asn Asn Leu Glu Ser Phe 
            180                 185                 190         


Tyr Gln Glu Met Ile Met Lys Lys Arg Leu Glu Glu Phe Gln Leu Met 
        195                 200                 205             


Arg Gly Glu Pro Phe Ala Ser His Ser Leu Val Ser Ala Thr Ser Val 
    210                 215                 220                 


Gly Asp Ser Gly Thr Ala Glu Ser Pro Ser Leu Leu Gln Asp Lys Gly 
225                 230                 235                 240 


Lys Gln Ala Ala Gln Gly Lys Gly Pro Ser Leu His Val Ala Asn Val 
                245                 250                 255     


Ile Asp Phe Ser Pro Glu Gln Cys Trp Thr Gly Pro Lys Lys Leu Thr 
            260                 265                 270         


Gln Pro Ile Glu Phe Val Pro Glu Asp Glu Ile Gln Arg Asn Arg Leu 
        275                 280                 285             


Ser Glu Glu Glu Ile Arg Lys Ile Pro Met Phe Ser Ser Tyr Asn Pro 
    290                 295                 300                 


Gly Glu Pro Asn Lys Val Leu Tyr Leu Lys Asn Leu Ser Pro Arg Val 
305                 310                 315                 320 


Thr Glu Arg Asp Leu Val Ser Leu Phe Ala Arg Phe Gln Glu Lys Lys 
                325                 330                 335     


Gly Pro Pro Ile Gln Phe Arg Met Met Thr Gly Arg Met Arg Gly Gln 
            340                 345                 350         


Ala Phe Ile Thr Phe Pro Asn Lys Glu Ile Ala Trp Gln Ala Leu His 
        355                 360                 365             


Leu Val Asn Gly Tyr Lys Leu Tyr Gly Lys Ile Leu Val Ile Glu Phe 
    370                 375                 380                 


Gly Lys Asn Lys Lys Gln Arg Ser Asn Leu Gln Ala Thr Ser Leu Ile 
385                 390                 395                 400 


Ser Cys Ala Thr Gly Ser Thr Thr Glu Ile Ser Gly Ser 
                405                 410             


<210>  4220
<211>  4775
<212>  DNA
<213>  Homosapiens

<400>  4220
acccgcgcga ggtaggcgct ctggtgcttg cggaggacgc ttccttcctc agatgcaccg     60

atcttcccga tactgccttt ggagcggcta gattgctagc cttggctgct ccattggcct    120

gccttgcccc ttacctgccg attgcatatg aactcttctt ctgtctgtac atcgttgtcg    180

tcggagtcgt cgcgatcgtc gtggcgctcg tgtgatggcc ttcgtccgtt tagagtagtg    240

tagttagtta ggggccaacg aagaagaaag aagacgcgat tagtgcagag atgctggagg    300

tggtcagtta ctaagctaga gtaagatagc ggagcgaaaa gagccaaacc tagccggggg    360

gcgcacggtc acccaaagga ggtcgactcg ccggcgcttc ctatcgcgcc gagctccctc    420

cattcctctc cctccgccga ggcgcgaggt tgcggcgcgc agcgcagcgc agctcagcgc    480

accgactgcc gcgggctccg ctgggcgatt gcagccgagt ccgtttctcg tctagctgcc    540

gccgcggcga ccgctgcctg gtcttcctcc cggacgctag tgggttatca gctaacaccc    600

gcgagcatct ataacatagg ccaactgacg ccatccttca aaaacaacta aaggatgata    660

tgatgaacct agcctgttaa tttcgtcttc tcaattttaa actttggttg cttaagactg    720

aagcaatcat ggtgaacctg aggaatgcgg tgcattcatt ccttgtgcac ctaattggcc    780

tattggtttg gcaatgtgat atttctgtga gcccagtagc agctatagta actgacattt    840

tcaatacctc cgatggtgga cgcttcaaat tcccagacgg ggtacaaaac tggccagcac    900

tttcaatcgt catcataata atcatgacaa taggtggcaa catccttgtg atcatggcag    960

taagcatgga aaagaaactg cacaatgcca ccaattactt cttaatgtcc ctagccattg   1020

ctgatatgct agtgggacta cttgtcatgc ccctgtctct cctggcaatc ctttatgatt   1080

atgtctggcc actacctaga tatttgtgcc ccgtctggat ttctttagat gttttatttt   1140

caacagcgtc catcatgcac ctctgcgcta tatcgctgga tcggtatgta gcaatacgta   1200

atcctattga gcatagccgt ttcaattcgc ggactaaggc catcatgaag attgctattg   1260

tttgggcaat ttctataggt gtatcagttc ctatccctgt gattggactg agggacgaag   1320

aaaaggtgtt cgtgaacaac acgacgtgcg tgctcaacga cccaaatttc gttcttattg   1380

ggtccttcgt agctttcttc ataccgctga cgattatggt gattacgtat tgcctgacca   1440

tctacgttct gcgccgacaa gctttgatgt tactgcacgg ccacaccgag gaaccgcctg   1500

gactaagtct ggatttcctg aagtgctgca agaggaatac ggccgaggaa gagaactctg   1560

caaaccctaa ccaagaccag aacgcacgcc gaagaaagaa gaaggagaga cgtcctaggg   1620

gcaccatgca ggctatcaac aatgaaagaa aagcttcgaa agtccttggg attgttttct   1680

ttgtgtttct gatcatgtgg tgcccatttt tcattaccaa tattctgtct gttctttgtg   1740

agaagtcctg taaccaaaag ctcatggaaa agcttctgaa tgtgtttgtt tggattggct   1800

atgtttgttc aggaatcaat cctctggtgt atactctgtt caacaaaatt taccgaaggg   1860

cattctccaa ctatttgcgt tgcaattata aggtagagaa aaagcctcct gtcaggcaga   1920

ttccaagagt tgccgccact gctttgtctg ggagggagct taatgttaac atttatcggc   1980

ataccaatga accggtgatc gagaaagcca gtgacaatga gcccggtata gagatgcaag   2040

ttgagaattt agagttacca gtaaatccct ccagtgtggt tagcgaaagg attagcagtg   2100

tgtgagaaag aacagcacag tcttttccta cggtacaagc tacatatgta ggaaaatttt   2160

cttctttaat ttttctgttg gtcttaacta atgtaaatat tgctgtctga aaaagtgttt   2220

ttacatatag ctttgcaacc ttgtacttta caatcatgcc tacattagtg agatttaggg   2280

ttctatattt actgtttata ataggtggag actaacttat tttgattgtt tgatgaataa   2340

aatgtttatt tttgctctcc ctcccttctt tccttccttt tttcctttct tccttccttt   2400

ctctctttct tttgtgcata tggcaacgtt catgttcatc tcaggtggca tttgcaggtg   2460

accagaatga ggcacatgac agtggttata tttcaaccac acctaaatta acaaattcag   2520

tggacatttg ttctgggtta acagtaaata tacactttac attcttgctc tgctcatcta   2580

cacatataaa cacagtaaga taggttctgc tttctgatac atctgtcagt gagtcagagg   2640

cagaacctag tcttgttgtt catatagggg caaaaatttg acattgtcag aatgttgtgt   2700

tggtatttac tgcaatgtct gtccctaaac atagtggtat tttaacatag cagctggtta   2760

accgggacta cagaagtgga aggataatga gatgtaatac accaaatagc ttttcacttc   2820

ttaaggacag tgttcaaatt ctgattatta caacaagcaa actgaaatta gtgttttcat   2880

tctggtcctt agtaaattcc taattctatg attaaactgg gaaatgagat cccagagtta   2940

tttcccaacc caggattcaa catcaattgg gttttgatct cagcatcctg gaaatttgtg   3000

tgcttcacac aaagtgaaat tagtattttg agccttatta aaatattttc ttaattatgg   3060

tacctctgtc tataggactt aatttagcag tccatttttg agtaaaactt gtattggaag   3120

tatagatggt agaaactttg gaagttttac ttgattaagg actacagaat tgggccctta   3180

gaatgtgaaa aaaaaaagta attaaaaaga cacttttacc gaactcggga ttacagaaac   3240

acggagtttc catttggatt ttaaacaaaa tttatgtcat tttcagatcc ttccaaactc   3300

tctagtgcag gaaaaggctg cagctaattt gtgaaagtgg caagctcttc attgcactgc   3360

agttatttac cagaagttta aatctttgtt aaaatatagt gttgtgttac aataagtgtt   3420

ggccatcatt tcattcgtgg gcctgctgct ctctaagaat tcagtagcat tttaatagtt   3480

tctaaaccat gaaaagtttt caagcattgc taaagtcagg ccattcagtc tatgctgtgt   3540

gcagagtata caagtgtttc tagtaacagt atttccatac gtgcccattt cacacaactg   3600

tggataaatt ttggaagaat tcatgatgct agttcttacg cttgacagtt acttacacac   3660

ctgagaatgt gcctctcagt atcttaaaat tggttaatga aaaatctgaa tttctaaaac   3720

ccttggtctg tgttctcaac acacagtata gataaatcca atagtctgcc acaagggcag   3780

tggaagagct gctgtatttg aggaaactca tacagtctct atttgatttg caacactggc   3840

caaacatcag tcatttgctt gagcatgccc aaatattaca tgaaagtcaa gtctacctgc   3900

cttgcctgtt aggtctgttg aagtgcatgt taaaataatt atatgaagca gaatgagatg   3960

atttaattct taccgaaatg aaaatggctg aagaaacaca gcatgcattt agcatgagtt   4020

ctgcacatac agatggtgtc ctgcatgtat gccatgtatg ttgcatgaat ccatcgattt   4080

gtattaatgt agggcagaat agctgataga agaaggactg aagaaaatcc ttcagcaatc   4140

cttaaaaaga ccatgcattc agatctgaag tagtgtgagt gttagaaaaa actggaaaca   4200

tctgatttct gaactatcag ggcaagctca tagcacatgt tttacaaaga aacaaaatat   4260

aaatcacaga tttccaaaag tactagcaat aagttgaatg ataatagctc acagcacatt   4320

tgttaatgat tcttgtgtca tcaagtagta gtacttaata gtacccaacc tggtaattat   4380

cctcaagttg tgtgctattc gtaagttctg tgcagtttgg tatgaaacaa atatactcat   4440

ttggatataa atcttaccct tcaatgttaa atctacaaac ttttataaat gttttaaaga   4500

agtccatgtg ataattgtaa aggtgatgaa tttaccatca aacaaatcat tttgatgtat   4560

tattatatat gtatatctgt gtaagacacg tgcaacagac tgccttatat tattttctgt   4620

aattcttctc ctttgtcaaa tggtattttt tgtgaatggt tgcaaagtgt tgtcttattc   4680

ctaattcctg tatgttatcc actacaggtt ttatgagact tcctattaat ttattaaatt   4740

tattaaatgt tgaaaaaaaa aaaaaaaaaa aaaaa                              4775


<210>  4221
<211>  458
<212>  PRT
<213>  Homosapiens

<400>  4221

Met Val Asn Leu Arg Asn Ala Val His Ser Phe Leu Val His Leu Ile 
1               5                   10                  15      


Gly Leu Leu Val Trp Gln Cys Asp Ile Ser Val Ser Pro Val Ala Ala 
            20                  25                  30          


Ile Val Thr Asp Ile Phe Asn Thr Ser Asp Gly Gly Arg Phe Lys Phe 
        35                  40                  45              


Pro Asp Gly Val Gln Asn Trp Pro Ala Leu Ser Ile Val Ile Ile Ile 
    50                  55                  60                  


Ile Met Thr Ile Gly Gly Asn Ile Leu Val Ile Met Ala Val Ser Met 
65                  70                  75                  80  


Glu Lys Lys Leu His Asn Ala Thr Asn Tyr Phe Leu Met Ser Leu Ala 
                85                  90                  95      


Ile Ala Asp Met Leu Val Gly Leu Leu Val Met Pro Leu Ser Leu Leu 
            100                 105                 110         


Ala Ile Leu Tyr Asp Tyr Val Trp Pro Leu Pro Arg Tyr Leu Cys Pro 
        115                 120                 125             


Val Trp Ile Ser Leu Asp Val Leu Phe Ser Thr Ala Ser Ile Met His 
    130                 135                 140                 


Leu Cys Ala Ile Ser Leu Asp Arg Tyr Val Ala Ile Arg Asn Pro Ile 
145                 150                 155                 160 


Glu His Ser Arg Phe Asn Ser Arg Thr Lys Ala Ile Met Lys Ile Ala 
                165                 170                 175     


Ile Val Trp Ala Ile Ser Ile Gly Val Ser Val Pro Ile Pro Val Ile 
            180                 185                 190         


Gly Leu Arg Asp Glu Glu Lys Val Phe Val Asn Asn Thr Thr Cys Val 
        195                 200                 205             


Leu Asn Asp Pro Asn Phe Val Leu Ile Gly Ser Phe Val Ala Phe Phe 
    210                 215                 220                 


Ile Pro Leu Thr Ile Met Val Ile Thr Tyr Cys Leu Thr Ile Tyr Val 
225                 230                 235                 240 


Leu Arg Arg Gln Ala Leu Met Leu Leu His Gly His Thr Glu Glu Pro 
                245                 250                 255     


Pro Gly Leu Ser Leu Asp Phe Leu Lys Cys Cys Lys Arg Asn Thr Ala 
            260                 265                 270         


Glu Glu Glu Asn Ser Ala Asn Pro Asn Gln Asp Gln Asn Ala Arg Arg 
        275                 280                 285             


Arg Lys Lys Lys Glu Arg Arg Pro Arg Gly Thr Met Gln Ala Ile Asn 
    290                 295                 300                 


Asn Glu Arg Lys Ala Ser Lys Val Leu Gly Ile Val Phe Phe Val Phe 
305                 310                 315                 320 


Leu Ile Met Trp Cys Pro Phe Phe Ile Thr Asn Ile Leu Ser Val Leu 
                325                 330                 335     


Cys Glu Lys Ser Cys Asn Gln Lys Leu Met Glu Lys Leu Leu Asn Val 
            340                 345                 350         


Phe Val Trp Ile Gly Tyr Val Cys Ser Gly Ile Asn Pro Leu Val Tyr 
        355                 360                 365             


Thr Leu Phe Asn Lys Ile Tyr Arg Arg Ala Phe Ser Asn Tyr Leu Arg 
    370                 375                 380                 


Cys Asn Tyr Lys Val Glu Lys Lys Pro Pro Val Arg Gln Ile Pro Arg 
385                 390                 395                 400 


Val Ala Ala Thr Ala Leu Ser Gly Arg Glu Leu Asn Val Asn Ile Tyr 
                405                 410                 415     


Arg His Thr Asn Glu Pro Val Ile Glu Lys Ala Ser Asp Asn Glu Pro 
            420                 425                 430         


Gly Ile Glu Met Gln Val Glu Asn Leu Glu Leu Pro Val Asn Pro Ser 
        435                 440                 445             


Ser Val Val Ser Glu Arg Ile Ser Ser Val 
    450                 455             


<210>  4222
<211>  1376
<212>  DNA
<213>  Homosapiens

<400>  4222
gtaagaacac tctcgtgagt ctaacggtct tccggatgaa ggctatttga agtcgccata     60

acctggtcag aagtgtgcct gtcggcgggg agagaggcaa tatcaaggtt ttaaatctcg    120

gagaaatggc tttcgtttgc ttggctatcg gatgcttata tacctttctg ataagcacaa    180

catttggctg tacttcatct tcagacaccg agataaaagt taaccctcct caggattttg    240

agatagtgga tcccggatac ttaggttatc tctatttgca atggcaaccc ccactgtctc    300

tggatcattt taaggaatgc acagtggaat atgaactaaa ataccgaaac attggtagtg    360

aaacatggaa gaccatcatt actaagaatc tacattacaa agatgggttt gatcttaaca    420

agggcattga agcgaagata cacacgcttt taccatggca atgcacaaat ggatcagaag    480

ttcaaagttc ctgggcagaa actacttatt ggatatcacc acaaggaatt ccagaaacta    540

aagttcagga tatggattgc gtatattaca attggcaata tttactctgt tcttggaaac    600

ctggcatagg tgtacttctt gataccaatt acaacttgtt ttactggtat gagggcttgg    660

atcatgcatt acagtgtgtt gattacatca aggctgatgg acaaaatata ggatgcagat    720

ttccctattt ggaggcatca gactataaag atttctatat ttgtgttaat ggatcatcag    780

agaacaagcc tatcagatcc agttatttca cttttcagct tcaaaatata gttaaacctt    840

tgccgccagt ctatcttact tttactcggg agagttcatg tgaaattaag ctgaaatgga    900

gcataccttt gggacctatt ccagcaaggt gttttgatta tgaaattgag atcagagaag    960

atgatactac cttggtgact gctacagttg aaaatgaaac atacaccttg aaaacaacaa   1020

atgaaacccg acaattatgc tttgtagtaa gaagcaaagt gaatatttat tgctcagatg   1080

acggaatttg gagtgagtgg agtgataaac aatgctggga aggtgaagac ctatcgaaga   1140

aaactttgct acgtttctgg ctaccatttg gtttcatctt aatattagtt atatttgtaa   1200

ccggtctgct tttgcgtaag ccaaacacct acccaaaaat gattccagaa tttttctgtg   1260

atacatgaag actttccata tcaagagaca tggtattgac tcaacagttt ccagtcatgg   1320

ccaaatgttc aatatgagtc tcaataaact gaatttttct tgcgaatgtt gaaaaa       1376


<210>  4223
<211>  380
<212>  PRT
<213>  Homosapiens

<400>  4223

Met Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile 
1               5                   10                  15      


Ser Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val 
            20                  25                  30          


Asn Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr 
        35                  40                  45              


Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu 
    50                  55                  60                  


Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
65                  70                  75                  80  


Trp Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp 
                85                  90                  95      


Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln 
            100                 105                 110         


Cys Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr 
        115                 120                 125             


Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp 
    130                 135                 140                 


Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly 
145                 150                 155                 160 


Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu 
                165                 170                 175     


Gly Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gly 
            180                 185                 190         


Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys 
        195                 200                 205             


Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg 
    210                 215                 220                 


Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro 
225                 230                 235                 240 


Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu 
                245                 250                 255     


Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr 
            260                 265                 270         


Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val 
        275                 280                 285             


Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gln Leu 
    290                 295                 300                 


Cys Phe Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly 
305                 310                 315                 320 


Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu 
                325                 330                 335     


Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu Pro Phe Gly Phe Ile Leu 
            340                 345                 350         


Ile Leu Val Ile Phe Val Thr Gly Leu Leu Leu Arg Lys Pro Asn Thr 
        355                 360                 365             


Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp Thr 
    370                 375                 380 


<210>  4224
<211>  4943
<212>  DNA
<213>  Homosapiens

<400>  4224
attgtcgggg gctattctct ctcccaggaa catggcggcg agtcagggag gaggcggtaa     60

cagtgggggc ggcggttgtg gtggaggtgg aagtagcggt ggctgtggca cggctggagg    120

gggaggtggc ggggctggag ggggaggcgg cggcggcggc gggaccctgg tggtccccat    180

cccggtaccg actcttttcg gtcagccgtt ccccaacggg ccgccgtgga acccggggag    240

cctgcagcct cagcacaccg tgaggagcct ggaccgggcc ctggaagagg cgggcagctc    300

cggcatcctg agcctcagtg gtcggaaact ccgagacttc ccgggcagcg gctacgacct    360

gacggacacc acccaagcag atctttccag aaatcgtttt acagaaattc cttctgatgt    420

ctggttattt gcaccccttg aaacattaaa tttatatcat aattgcatca aaaccattcc    480

tgaagccatt aaaaatctgc agatgttaac ataccttaac attagccgaa atcttttatc    540

aacattgcca aaatacctat ttgatcttcc ccttaaagtt ttggtcgtca gtaataataa    600

actggtatcc attccagaag aaattgggaa gttaaaagat ttaatggaat tggatattag    660

ctgcaatgag attcaagtcc ttccccaaca aatgggaaaa ttacattcac ttagagagct    720

aaatataaga agaaataatc ttcatgtttt gccagatgaa ttaggagacc ttcccttagt    780

caagctggat ttctcttgta ataaagtgac cgaaattcca gtttgttaca gaaagctgca    840

tcatttacaa gtaataattt tggataacaa tccattgcaa gtaccaccag cacagatatg    900

tttaaagggt aaggtgcaca tatttaagta cttaaatatt caagcatgtt gcagaatgga    960

taagaaacca gattccctgg atcttccatc attgagtaaa cgaatgccct cacagcctct   1020

cacagacagt atggaagatt tttatccaaa taaaaatcat ggccctgact ctggaattgg   1080

aagtgataat ggagagaaac gattatccac aacagaacca tcagatgatg acacagtcag   1140

ccttcattct caagtctcag aatcaaatag agagcagaca tcaagaaatg acagtcacat   1200

aataggaagt aagactgatt ctcagaaaga ccaggaggta tatgattttg ttgaccccaa   1260

cacagaagat gtagcagttc ctgaacaggg aaatgcacat attggatcat ttgtatcatt   1320

ctttaaggga aaagaaaaat gttctgaaaa atctcggaaa aatgaagaat taggagatga   1380

aaaaagactt gagaaagaac agttactggc agaggaagag gatgatgatt tgaaggaagt   1440

aactgatttg aggaaaatag ctgctcagtt attgcagcaa gaacagaaga acaggattct   1500

taatcattca acttctgtga tgagaaacaa gccaaaacaa actgtggaat gtgaaaagag   1560

tgtctcagca gatgaagtta attcaccatt atcacccctc acctggcagc ccttagaaaa   1620

tcagaaggat caaatagatg aacaaccgtg gccagaatct caccctataa tctggcagag   1680

tgaagaaagg aggcggagca aacagattag aaaagaatat ttcaagtata aatcaatgag   1740

gaagagttca agtggcaatg aaaatgatga gcaagacagt gataatgcta atatgtcaac   1800

acaatctcca gtatcatctg aggaatatga cagaactgat ggtttttcac acagtccctt   1860

tggcttgaag cctagatcag cttttagccg ctcatctcgc caagaatatg gggcagcaga   1920

tccaggattt acaatgagaa gaaagatgga acatttacgg gaagagcgag agcaaatacg   1980

acaacttcgc aacaatcttg aatccaggtt aaaagtaatt ttgcctgatg acattggagc   2040

tgcactgatg gatggggttg ttctttgcca tttagccaat catataaggc cacgttctgt   2100

tgctagtatt catgtaccat caccagcagt gcccaaactg agcatggcaa aatgtcgaag   2160

aaatgtagaa aattttcttg atgcttgtaa aaagttgggt gtctcacaga ggaaagactt   2220

tgtttgcctc atcatatttt ggaagaacga ggacttgtga aagttggtgt cacagttcag   2280

gcgctccttg aattaccaac aaccaaggca tctcagcttt ctgtggctta atataacatt   2340

ttaaaattct aagtgtatag tttcatttat ttgaagtgat ttcaaatatt tcaaattcat   2400

gaataagaat attccgtcaa aaatagtttg ccttaggtca cgccttagga ttttaaaaaa   2460

attacattga aacatcaaac ttaaacattg aattgcccga acttctttgg gggaaaactg   2520

gattaactta ataagagtat ttgataaact caaattctct ttttactaag tcagttgata   2580

atcttgatta tttttcagaa agcagactga tactaaattt aaaatgtagt ttcaatttaa   2640

taatcacatt aggtttaatt tttttacatc atagcatatt agtaaacatc tggataaagg   2700

taattttttt tagcaattta gagcaattct atatttgagt tatttaatac acttctaatt   2760

ctagtttata cacaatttct tcaatctttg gtcttagttt tctagaaaaa aggagtagaa   2820

aaaacaattc tggctttata ttaaattctt ttagtattat aggttggtgc caaaatattt   2880

tcagttgtac tgtagattgt ttacatgtga agtgcctgtg taattgatga ctcttacata   2940

gtcttaagca tttttgcaat tttttaaatg tattaataga gtcaatggaa ctttaaaata   3000

ttttagtaga ttttgtaaag tcagtaatat gtgaggattt aaatgagcct cacattgtga   3060

catttgtggt tttttagtta gtccattgca gtttccctta aattggttat ttcatgttgt   3120

caaaaatacc aatgttaata tgattaattt atgctattta attttgtgaa acttaatcat   3180

cttttaaaat gtattatttg aagagtattt tatttctgta ttgaaaatgt tacacaaagc   3240

agtaaagttt ttgagaacta gtgaagtact aattatcaag gacattttga taaaactgcc   3300

aaagtttggg tttatatctt ccctttgagc agcattctat cagtgctgcc tttagctata   3360

ctcagagagc agcagttgag gaataggttt ttactcaaaa tctggccatt tgtgaatcct   3420

gtaaaccttg tgatcttcaa ttactttgat gttaaattaa acacagactc ttctataaat   3480

attttcatga gatactgtgt tacacaaagt ccttgtttta acttaggtat gggtaaattt   3540

acattggtgg tattgcagga atttttcaaa aacattactg taatgaataa ctgagtttcc   3600

tatagaagaa cctgaataat tacttttgta gtaaccaagc aagcatcata tcttaagtat   3660

gtgatcattt gcacttgtta cctcttaata tggatgcaac ttattaaaaa tgttggcctg   3720

ggtatttcaa agggtatata taaaaggtaa aaaactagtg tgccaaatgg tataggaaca   3780

actgtacttt ttttgatcag ttggcatgaa gccatagaat taaattttgg ctttagaata   3840

cagatgtgtt cattacattc cccaagggtc aaattggagc ttttaaagaa ttaaagcttc   3900

tatgagtata tggtttaaga attaaattat tagtaattta ttattttaaa tatttgacct   3960

cattagttgt taatttttta gttggataaa aaaaaaactc gctgacataa tctccctagt   4020

gaaaacttgg gtaatatatg taagaaatgg caaataaata ccttagttaa tgacttttta   4080

tgtagaaatt tgacagcatt acaaattaag tgaccattaa aaacacagca atcattcata   4140

ctgctttcat aggtgttatg atagtctctg attaatcaat ctagtatgaa ttattttaca   4200

agtgttgtcc tgtttcatat ctttgaagta gtagtgaaat tgtaggccat tttcttataa   4260

catttcagtt acttttcagt taattattcc tttaaaaaga aaatacagca gaacctcact   4320

gtagcattct ttactgcaga gcaaaattca atttaagatg ggcttctctg aggtccacat   4380

catggcagtt catttactct tgtgccaaat ggcaacacca cgtctaaagc agtttcacag   4440

catggtcccc tacaatgtta taccaaggct ctgatgtatt tcttttagta gtttctaagt   4500

gtaaaattta ttctaaatgt ttttatggct attatctatt tcatcagtta ttgaattaag   4560

aatgattttc attacttgag tgggatttgt gatttaatga cagttgaata atcaaaaata   4620

ttttattagg cccccaaaat ttaatagata tctatttctg ttacatttta ttactgtatg   4680

gcacaagaaa gaagtgacat tgggtatgtt agaaatgaaa taaggagtaa aaatgcatta   4740

ccatttgttt aataattatc tttacagaat gctagtttaa tgactttttt aactgaattt   4800

tttgaataaa tcagaaatgt ttgtattggt cacagatcta tcataattgc ttttctgatg   4860

catttaaaaa taaatggaac acttaaatgt atattaccga tgcaaactgt ggataaagtt   4920

gaaagaaaaa aaaaaaaaaa aaa                                           4943


<210>  4225
<211>  742
<212>  PRT
<213>  Homosapiens

<400>  4225

Met Ala Ala Ser Gln Gly Gly Gly Gly Asn Ser Gly Gly Gly Gly Cys 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Gly Gly Cys Gly Thr Ala Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Thr Leu Val Val 
        35                  40                  45              


Pro Ile Pro Val Pro Thr Leu Phe Gly Gln Pro Phe Pro Asn Gly Pro 
    50                  55                  60                  


Pro Trp Asn Pro Gly Ser Leu Gln Pro Gln His Thr Val Arg Ser Leu 
65                  70                  75                  80  


Asp Arg Ala Leu Glu Glu Ala Gly Ser Ser Gly Ile Leu Ser Leu Ser 
                85                  90                  95      


Gly Arg Lys Leu Arg Asp Phe Pro Gly Ser Gly Tyr Asp Leu Thr Asp 
            100                 105                 110         


Thr Thr Gln Ala Asp Leu Ser Arg Asn Arg Phe Thr Glu Ile Pro Ser 
        115                 120                 125             


Asp Val Trp Leu Phe Ala Pro Leu Glu Thr Leu Asn Leu Tyr His Asn 
    130                 135                 140                 


Cys Ile Lys Thr Ile Pro Glu Ala Ile Lys Asn Leu Gln Met Leu Thr 
145                 150                 155                 160 


Tyr Leu Asn Ile Ser Arg Asn Leu Leu Ser Thr Leu Pro Lys Tyr Leu 
                165                 170                 175     


Phe Asp Leu Pro Leu Lys Val Leu Val Val Ser Asn Asn Lys Leu Val 
            180                 185                 190         


Ser Ile Pro Glu Glu Ile Gly Lys Leu Lys Asp Leu Met Glu Leu Asp 
        195                 200                 205             


Ile Ser Cys Asn Glu Ile Gln Val Leu Pro Gln Gln Met Gly Lys Leu 
    210                 215                 220                 


His Ser Leu Arg Glu Leu Asn Ile Arg Arg Asn Asn Leu His Val Leu 
225                 230                 235                 240 


Pro Asp Glu Leu Gly Asp Leu Pro Leu Val Lys Leu Asp Phe Ser Cys 
                245                 250                 255     


Asn Lys Val Thr Glu Ile Pro Val Cys Tyr Arg Lys Leu His His Leu 
            260                 265                 270         


Gln Val Ile Ile Leu Asp Asn Asn Pro Leu Gln Val Pro Pro Ala Gln 
        275                 280                 285             


Ile Cys Leu Lys Gly Lys Val His Ile Phe Lys Tyr Leu Asn Ile Gln 
    290                 295                 300                 


Ala Cys Cys Arg Met Asp Lys Lys Pro Asp Ser Leu Asp Leu Pro Ser 
305                 310                 315                 320 


Leu Ser Lys Arg Met Pro Ser Gln Pro Leu Thr Asp Ser Met Glu Asp 
                325                 330                 335     


Phe Tyr Pro Asn Lys Asn His Gly Pro Asp Ser Gly Ile Gly Ser Asp 
            340                 345                 350         


Asn Gly Glu Lys Arg Leu Ser Thr Thr Glu Pro Ser Asp Asp Asp Thr 
        355                 360                 365             


Val Ser Leu His Ser Gln Val Ser Glu Ser Asn Arg Glu Gln Thr Ser 
    370                 375                 380                 


Arg Asn Asp Ser His Ile Ile Gly Ser Lys Thr Asp Ser Gln Lys Asp 
385                 390                 395                 400 


Gln Glu Val Tyr Asp Phe Val Asp Pro Asn Thr Glu Asp Val Ala Val 
                405                 410                 415     


Pro Glu Gln Gly Asn Ala His Ile Gly Ser Phe Val Ser Phe Phe Lys 
            420                 425                 430         


Gly Lys Glu Lys Cys Ser Glu Lys Ser Arg Lys Asn Glu Glu Leu Gly 
        435                 440                 445             


Asp Glu Lys Arg Leu Glu Lys Glu Gln Leu Leu Ala Glu Glu Glu Asp 
    450                 455                 460                 


Asp Asp Leu Lys Glu Val Thr Asp Leu Arg Lys Ile Ala Ala Gln Leu 
465                 470                 475                 480 


Leu Gln Gln Glu Gln Lys Asn Arg Ile Leu Asn His Ser Thr Ser Val 
                485                 490                 495     


Met Arg Asn Lys Pro Lys Gln Thr Val Glu Cys Glu Lys Ser Val Ser 
            500                 505                 510         


Ala Asp Glu Val Asn Ser Pro Leu Ser Pro Leu Thr Trp Gln Pro Leu 
        515                 520                 525             


Glu Asn Gln Lys Asp Gln Ile Asp Glu Gln Pro Trp Pro Glu Ser His 
    530                 535                 540                 


Pro Ile Ile Trp Gln Ser Glu Glu Arg Arg Arg Ser Lys Gln Ile Arg 
545                 550                 555                 560 


Lys Glu Tyr Phe Lys Tyr Lys Ser Met Arg Lys Ser Ser Ser Gly Asn 
                565                 570                 575     


Glu Asn Asp Glu Gln Asp Ser Asp Asn Ala Asn Met Ser Thr Gln Ser 
            580                 585                 590         


Pro Val Ser Ser Glu Glu Tyr Asp Arg Thr Asp Gly Phe Ser His Ser 
        595                 600                 605             


Pro Phe Gly Leu Lys Pro Arg Ser Ala Phe Ser Arg Ser Ser Arg Gln 
    610                 615                 620                 


Glu Tyr Gly Ala Ala Asp Pro Gly Phe Thr Met Arg Arg Lys Met Glu 
625                 630                 635                 640 


His Leu Arg Glu Glu Arg Glu Gln Ile Arg Gln Leu Arg Asn Asn Leu 
                645                 650                 655     


Glu Ser Arg Leu Lys Val Ile Leu Pro Asp Asp Ile Gly Ala Ala Leu 
            660                 665                 670         


Met Asp Gly Val Val Leu Cys His Leu Ala Asn His Ile Arg Pro Arg 
        675                 680                 685             


Ser Val Ala Ser Ile His Val Pro Ser Pro Ala Val Pro Lys Leu Ser 
    690                 695                 700                 


Met Ala Lys Cys Arg Arg Asn Val Glu Asn Phe Leu Asp Ala Cys Lys 
705                 710                 715                 720 


Lys Leu Gly Val Ser Gln Arg Lys Asp Phe Val Cys Leu Ile Ile Phe 
                725                 730                 735     


Trp Lys Asn Glu Asp Leu 
            740         


<210>  4226
<211>  1745
<212>  DNA
<213>  Homosapiens

<400>  4226
acctcggagt gtgtggcgcc atgatgcagg gaagatggct tcgtttcgga agctaacgct     60

ttctgaaaaa gtgccgccaa atcatcccag tcggaaaaag gttaacttcc tagatatgtc    120

tctagacgac attataatct ataaagagtt agaagggaca aatgctgaag aagaaaagaa    180

taaaagacag aaccatagta aaaaggaatc gccttcaaga cagcaatcaa aagctcatag    240

acatcgccat cggagaggct actcaagatg cagaagcaac tctgaggaag gaaatcatga    300

taaaaaacca tcccaaaaac cttctggatt caagtctgga caacaccctt taaatgggca    360

gcctttaatt gagcaggaga agtgcagtga caattatgag gcccaagcag agaagaatca    420

aggccagtca gaggggaacc agcatcaatc agaaggaaat ccggacaaat cagaagaatc    480

ccagggccaa ccagaagaaa atcatcattc tgagcgatcc cgaaaccact tagagagatc    540

tctttctcag tcagacagat ctcaagggca gctaaagaga catcatcccc aatatgagag    600

atctcatggc caatacaaga gatctcatgg tcaatctgag agatctcatg gccactcaga    660

gagatctcat ggtcactcag agagatctca tggtcactca gagagatctc atggtcactc    720

aaagagatct cgtagccagg gagatcttgt ggacactcag agtgatctca tagccactca    780

gagagatctc atagccactc agaaagatct catagccact cagagagatc tcatagccac    840

tcagagagat ctcatagtca ctcagagaga tctcgtggcc actgagagag atctcataaa    900

tcagtcaggg agatctcatg gccaatcaga aagacatcag agatactcaa caggtaaaaa    960

tacaataact acttaatcat cagaacaatg tgttgaattc tgtggaaata gaaaagcata   1020

tatctatatt ctaatggcta aatatgtatt tgttgaaaca tgtatattgg gacaaagaca   1080

taaatattag aatggaggta atacatacat agtatcaata ttgtttcaac ttgatgtcct   1140

ctaagctatc atccagttac ccaagatgtc ccattaagtt gttcccggta ggtctgcttt   1200

ccctggaaga gccgtatgta ctcagccttt cctattgggc cttccccaca attagaatat   1260

tttgacttag tgtcctgtcc cccttggacg ttccaacttg acttagtgtc cagtgcccct   1320

tggacattcc aacctggtag gtaagctaat ctaacaacta actgccaaat tgataatata   1380

taatctatga taatgaatat ctcttttgtg tctccttcct aagccatcct cagagagtcc   1440

ttagcagaca aatggtagat gtatctttgg gcagctgaac ttttctgctt tcctcaaatc   1500

agaccatatg agaggatata ttctatgcat agatgtaatg ctaaccttct gaatatattt   1560

tgaatacatt tatatattca ctgttgcctt ataaaactgt tagggtaggt ctgtctaccc   1620

tagcaaaaga aacacagaaa tttaaatgta ctgggagtta tgttgttaaa aacacaagat   1680

atgttaactg cagtttgttt ggttattcaa taaaagtttt agttttaaaa aaaaaaaaaa   1740

aaaaa                                                               1745


<210>  4227
<211>  313
<212>  PRT
<213>  Homosapiens

<400>  4227

Met Ala Ser Phe Arg Lys Leu Thr Leu Ser Glu Lys Val Pro Pro Asn 
1               5                   10                  15      


His Pro Ser Arg Lys Lys Val Asn Phe Leu Asp Met Ser Leu Asp Asp 
            20                  25                  30          


Ile Ile Ile Tyr Lys Glu Leu Glu Gly Thr Asn Ala Glu Glu Glu Lys 
        35                  40                  45              


Asn Lys Arg Gln Asn His Ser Lys Lys Glu Ser Pro Ser Arg Gln Gln 
    50                  55                  60                  


Ser Lys Ala His Arg His Arg His Arg Arg Gly Tyr Ser Arg Cys Arg 
65                  70                  75                  80  


Ser Asn Ser Glu Glu Gly Asn His Asp Lys Lys Pro Ser Gln Lys Pro 
                85                  90                  95      


Ser Gly Phe Lys Ser Gly Gln His Pro Leu Asn Gly Gln Pro Leu Ile 
            100                 105                 110         


Glu Gln Glu Lys Cys Ser Asp Asn Tyr Glu Ala Gln Ala Glu Lys Asn 
        115                 120                 125             


Gln Gly Gln Ser Glu Gly Asn Gln His Gln Ser Glu Gly Asn Pro Asp 
    130                 135                 140                 


Lys Ser Glu Glu Ser Gln Gly Gln Pro Glu Glu Asn His His Ser Glu 
145                 150                 155                 160 


Arg Ser Arg Asn His Leu Glu Arg Ser Leu Ser Gln Ser Asp Arg Ser 
                165                 170                 175     


Gln Gly Gln Leu Lys Arg His His Pro Gln Tyr Glu Arg Ser His Gly 
            180                 185                 190         


Gln Tyr Lys Arg Ser His Gly Gln Ser Glu Arg Ser His Gly His Ser 
        195                 200                 205             


Glu Arg Ser His Gly His Ser Glu Arg Ser His Gly His Ser Glu Arg 
    210                 215                 220                 


Ser His Gly His Ser Lys Arg Ser Arg Ser Gln Gly Asp Leu Val Asp 
225                 230                 235                 240 


Thr Gln Ser Asp Leu Ile Ala Thr Gln Arg Asp Leu Ile Ala Thr Gln 
                245                 250                 255     


Lys Asp Leu Ile Ala Thr Gln Arg Asp Leu Ile Ala Thr Gln Arg Asp 
            260                 265                 270         


Leu Ile Val Thr Gln Arg Asp Leu Val Ala Thr Glu Arg Asp Leu Ile 
        275                 280                 285             


Asn Gln Ser Gly Arg Ser His Gly Gln Ser Glu Arg His Gln Arg Tyr 
    290                 295                 300                 


Ser Thr Gly Lys Asn Thr Ile Thr Thr 
305                 310             


<210>  4228
<211>  4520
<212>  DNA
<213>  Homosapiens

<400>  4228
taggaacagg ggagagtgca cctgctacca gtcaagctca gccagactgc aagaggaggc     60

gaggcggagc cagccgaggg agtgaaccat ggacaagttg aaatgcccga gtttcttcaa    120

gtgcagggag aaggagaaag tgtcggcttc atcagagaat ttccatgttg gtgaaaatga    180

tgagaatcag gaccgtggta actggtccaa aaaatcggat tatcttctat ctatgattgg    240

atacgcagtg ggattaggaa atgtgtggag atttccatat ctgacctaca gcaatggtgg    300

aggcgccttc ttgatacctt atgcaattat gttagcattg gctggtttac ctttgttctt    360

tctggagtgt tcactgggac aatttgctag cttaggtcca gtttcagttt ggaggattct    420

tccattgttt caaggtgtgg gaattacaat ggtcctgatc tccatttttg tgacaatcta    480

ttacaatgtc ataattgcct atagtcttta ctacatgttt gcttcttttc aaagtgaact    540

accatggaaa aattgttctt cgtggtcaga taaaaactgt agcagatcac caatagtaac    600

tcactgtaat gtgagtacag tgaataaagg aatacaagag atcatccaaa tgaataaaag    660

ctgggtagac atcaacaatt ttacctgcat caacggcagt gaaatttatc agccagggca    720

gcttcccagt gaacaatatt ggaataaagt ggcgctccaa cggtcaagtg gaatgaatga    780

gactggagta attgtttggt atttagcact ttgtcttctt ctggcttggc tcatagttgg    840

agcagcacta tttaaaggaa tcaaatcgtc tggcaaggtg gtatatttta cagctctttt    900

cccctatgtg gtcctactca tcctgttagt acgaggtgca actctggagg gtgcttcaaa    960

aggcatttca tactatattg gagcccagtc aaattttaca aaacttaagg aagctgaggt   1020

atggaaagat gctgccactc agatatttta ctccctttca gtggcttggg gtggcttagt   1080

tgctctatca tcttacaata agttcaaaaa caactgcttc tctgatgcca ttgtggtttg   1140

tttgacaaac tgtctcacta gcgtgtttgc tggatttgct attttttcta tattgggaca   1200

catggcccat atatctggaa aggaagtttc tcaagttgta aaatcaggtt ttgatttggc   1260

attcattgcc tatccagagg ctctagccca actcccaggt ggtccatttt ggtccatatt   1320

attttttttc atgcttttaa ctttgggtct cgattctcag tttgcttcga ttgaaacgat   1380

cacaacaaca attcaagatt tatttcccaa agtgatgaag aaaatgaggg ttcccataac   1440

tttgggctgc tgcttggttt tgtttctcct tggtctcgtc tgtgtgactc aggctggaat   1500

ttactgggtt catctgattg accacttctg tgctggatgg ggcattttaa ttgcagctat   1560

actggagcta gttggaatca tctggattta tggagggaac agattcattg aggatacaga   1620

aatgatgatt ggagcaaaga ggtggatatt ctggctatgg tggagagctt gctggtttgt   1680

aattacgcct atccttttga ttgcaatatt tatctggtca ttggtgcaat ttcatagacc   1740

taattatggc gcaattccat accctgactg gggagttgct ttaggctggt gtatgattgt   1800

tttctgcatt atttggatac caattatggc tatcataaaa ataattcagg ctaaaggaaa   1860

catctttcaa cgccttataa gttgctgcag accagcttct aactggggtc catacctgga   1920

acaacatcgt ggggaaagat ataaagacat ggtagatcct aaaaaagagg ctgaccatga   1980

aatacctact gttagtggca gcagaaaacc ggaatgagat ctcattgaaa aaaatatatg   2040

attgtataat gtgatttttt ttagaatagg gggaacctta tttatttgtg tgttaactga   2100

ataggaaaat gtacatacta tgttcatgat agtgtgattt ttttcacatt taagcaggaa   2160

tgcaatataa aaatgtgaat ctcttaattc tcagccatgt gcttattata tttcttttta   2220

gattgtctat ctgtataaca cacacacaca cacctaagag tctctatttc acaattatat   2280

ttttgtaaat agtatatgca tttttaatac attggaggct ttattttgaa ctaatttctt   2340

agagaatagt tatattttct attacacaag tttaaaaata ttattaactt gtattttctt   2400

aatatacaat ctatcttttc cacaaatatg agtgggaaat aaatcagcac atttgaaaga   2460

aagtgttaaa actgaaggcc tcacttaatt agaaacgtga taaatatatg gacaaatgga   2520

ctatacatac tataagagga ctgtagttta atacttttta cccaaatatg tttaaaaaca   2580

tcgtgcattt gttacagctc atgttttcta tatgaactta gtcattaatg ttctttataa   2640

aaagtgaaat aagatggaaa aattaggatc ctacagccag tacgtgataa atctagaaaa   2700

ttgagttttg agtacctctt ttcccatata caatcttcct tccttaggta atttggaaga   2760

aaactatgac ccatttaatt tctattgtgt ttcaccaaat tcagtgttgt tcattatacc   2820

tctctgaaat ataggtttaa tttcaaatag aatatggact taaatgttaa tgagaaactg   2880

gctttaatca attctagcat tttattactg taatacaggg ctgatagagt gattttgtct   2940

tatatgagtc agttactact tacaggtgat aacttgcata ctattggaag ataaagttgt   3000

caaacttgtc aagaatgaga aaagccaaat tagaaaatcc tatgtcctag tttccttacc   3060

aaggataatt aaatatatca ctaagagctt tatatattga ttatatattg ttgacaactg   3120

gtttaagcat catagcctat gatgataaac actgcctata tatgtaaata gcttttcatc   3180

aattcttaaa tttcttaacc taggcttcag ggagcatatg aaaccaaaat tatatggaac   3240

attttctgtg tgtacatgta catgcatttt tctagggaga gagtccgtag gtttatcaga   3300

atatcaagga aaactgtgac ccaaagaagt ttaagaatca catacagtgc tgctggcttt   3360

ttgtgcttgg caaatgagtg acaatagaag aaataatttt tcttacacat tttaaaacgt   3420

tttctcttcc ttgtgattga agatgaaagg agtaagaaat taaggcattt gtttaattta   3480

tactggtaac ttatttaggg gggaggggac atgaaggtag gtaaataggt aggcctctaa   3540

ttgaaccacc tctctaagtt atgtacgtat atataagctg aaattgtgtt tgacattctg   3600

agggttttct ttttcttttt cctttttttt tttttttggt ggggggctgg gggtcagagt   3660

cttgttctgt tgcctgggct ggagtgcagt ggcatgatct cagctcactg caacctctgc   3720

cttctggatt caagtgattc tcctgcctca gcctcttgag tagctgggac tacaggtgcc   3780

cgccaccaca ccagctaatt tttgtatttt tagtagaggc gaagtttccc catgttggcc   3840

aggctggtct tgaactcccg acctcaagtg atctgtctac ctcggcctcc taaagtgctg   3900

agattacagg tgtgagccac cgtgcccggc ccattctaag ggttttcttt gaagacaggt   3960

caaatgctgt tagtaagttt caggagattg ttaattcctc agttatacca gattttataa   4020

aatatttgag aatagatggc taacaagagg ttagaaatac ttttccttaa ttttaatcca   4080

cagtatgtta catgcattct accactacat tttggtgcta tttaaggtgt gcaattttct   4140

ataggtgact tttgcaattc agggaagatt tgggcatatt aaatgaaaga atatctaatt   4200

gggggaggtg tgaagggaaa gaaattcttt tcaaaagctg accacaaaga gtagttaaaa   4260

gtttttgtca ctatcttcac aagtgtgtaa agcacagatt tcaacagagt gcttggcata   4320

ttgtagggtg ctcaatggtg gtttttatta ttattactca gattccacag tggcaagaaa   4380

catcattcta cataatggaa aacatttaca tcaaatccca cttactttaa tgcgaacttg   4440

gagataattt atggtattgt attgtaaacc attaatgaaa actttttcac agttgagtga   4500

aattaaaatc actatatctc                                               4520


<210>  4229
<211>  642
<212>  PRT
<213>  Homosapiens

<400>  4229

Met Asp Lys Leu Lys Cys Pro Ser Phe Phe Lys Cys Arg Glu Lys Glu 
1               5                   10                  15      


Lys Val Ser Ala Ser Ser Glu Asn Phe His Val Gly Glu Asn Asp Glu 
            20                  25                  30          


Asn Gln Asp Arg Gly Asn Trp Ser Lys Lys Ser Asp Tyr Leu Leu Ser 
        35                  40                  45              


Met Ile Gly Tyr Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
    50                  55                  60                  


Leu Thr Tyr Ser Asn Gly Gly Gly Ala Phe Leu Ile Pro Tyr Ala Ile 
65                  70                  75                  80  


Met Leu Ala Leu Ala Gly Leu Pro Leu Phe Phe Leu Glu Cys Ser Leu 
                85                  90                  95      


Gly Gln Phe Ala Ser Leu Gly Pro Val Ser Val Trp Arg Ile Leu Pro 
            100                 105                 110         


Leu Phe Gln Gly Val Gly Ile Thr Met Val Leu Ile Ser Ile Phe Val 
        115                 120                 125             


Thr Ile Tyr Tyr Asn Val Ile Ile Ala Tyr Ser Leu Tyr Tyr Met Phe 
    130                 135                 140                 


Ala Ser Phe Gln Ser Glu Leu Pro Trp Lys Asn Cys Ser Ser Trp Ser 
145                 150                 155                 160 


Asp Lys Asn Cys Ser Arg Ser Pro Ile Val Thr His Cys Asn Val Ser 
                165                 170                 175     


Thr Val Asn Lys Gly Ile Gln Glu Ile Ile Gln Met Asn Lys Ser Trp 
            180                 185                 190         


Val Asp Ile Asn Asn Phe Thr Cys Ile Asn Gly Ser Glu Ile Tyr Gln 
        195                 200                 205             


Pro Gly Gln Leu Pro Ser Glu Gln Tyr Trp Asn Lys Val Ala Leu Gln 
    210                 215                 220                 


Arg Ser Ser Gly Met Asn Glu Thr Gly Val Ile Val Trp Tyr Leu Ala 
225                 230                 235                 240 


Leu Cys Leu Leu Leu Ala Trp Leu Ile Val Gly Ala Ala Leu Phe Lys 
                245                 250                 255     


Gly Ile Lys Ser Ser Gly Lys Val Val Tyr Phe Thr Ala Leu Phe Pro 
            260                 265                 270         


Tyr Val Val Leu Leu Ile Leu Leu Val Arg Gly Ala Thr Leu Glu Gly 
        275                 280                 285             


Ala Ser Lys Gly Ile Ser Tyr Tyr Ile Gly Ala Gln Ser Asn Phe Thr 
    290                 295                 300                 


Lys Leu Lys Glu Ala Glu Val Trp Lys Asp Ala Ala Thr Gln Ile Phe 
305                 310                 315                 320 


Tyr Ser Leu Ser Val Ala Trp Gly Gly Leu Val Ala Leu Ser Ser Tyr 
                325                 330                 335     


Asn Lys Phe Lys Asn Asn Cys Phe Ser Asp Ala Ile Val Val Cys Leu 
            340                 345                 350         


Thr Asn Cys Leu Thr Ser Val Phe Ala Gly Phe Ala Ile Phe Ser Ile 
        355                 360                 365             


Leu Gly His Met Ala His Ile Ser Gly Lys Glu Val Ser Gln Val Val 
    370                 375                 380                 


Lys Ser Gly Phe Asp Leu Ala Phe Ile Ala Tyr Pro Glu Ala Leu Ala 
385                 390                 395                 400 


Gln Leu Pro Gly Gly Pro Phe Trp Ser Ile Leu Phe Phe Phe Met Leu 
                405                 410                 415     


Leu Thr Leu Gly Leu Asp Ser Gln Phe Ala Ser Ile Glu Thr Ile Thr 
            420                 425                 430         


Thr Thr Ile Gln Asp Leu Phe Pro Lys Val Met Lys Lys Met Arg Val 
        435                 440                 445             


Pro Ile Thr Leu Gly Cys Cys Leu Val Leu Phe Leu Leu Gly Leu Val 
    450                 455                 460                 


Cys Val Thr Gln Ala Gly Ile Tyr Trp Val His Leu Ile Asp His Phe 
465                 470                 475                 480 


Cys Ala Gly Trp Gly Ile Leu Ile Ala Ala Ile Leu Glu Leu Val Gly 
                485                 490                 495     


Ile Ile Trp Ile Tyr Gly Gly Asn Arg Phe Ile Glu Asp Thr Glu Met 
            500                 505                 510         


Met Ile Gly Ala Lys Arg Trp Ile Phe Trp Leu Trp Trp Arg Ala Cys 
        515                 520                 525             


Trp Phe Val Ile Thr Pro Ile Leu Leu Ile Ala Ile Phe Ile Trp Ser 
    530                 535                 540                 


Leu Val Gln Phe His Arg Pro Asn Tyr Gly Ala Ile Pro Tyr Pro Asp 
545                 550                 555                 560 


Trp Gly Val Ala Leu Gly Trp Cys Met Ile Val Phe Cys Ile Ile Trp 
                565                 570                 575     


Ile Pro Ile Met Ala Ile Ile Lys Ile Ile Gln Ala Lys Gly Asn Ile 
            580                 585                 590         


Phe Gln Arg Leu Ile Ser Cys Cys Arg Pro Ala Ser Asn Trp Gly Pro 
        595                 600                 605             


Tyr Leu Glu Gln His Arg Gly Glu Arg Tyr Lys Asp Met Val Asp Pro 
    610                 615                 620                 


Lys Lys Glu Ala Asp His Glu Ile Pro Thr Val Ser Gly Ser Arg Lys 
625                 630                 635                 640 


Pro Glu 
        


<210>  4230
<211>  552
<212>  DNA
<213>  Homosapiens

<400>  4230
ggggagttac accaggcatc ctggcccaaa gtttcccaaa tccaggcggc tagaggccca     60

ctgcttccca actaccagct gagggggtcc gtcccgagaa gggagaagag gccgaagagg    120

aaacatgaac ttctatttac tcctagcgag cagcattctg tgtgccttga ttgtcttctg    180

gaaatatcgc cgctttcaga gaaacactgg cgaaatgtca tcaaattcaa ctgctcttgc    240

actagtgaga ccctcttctt ctgggttaat taacagcaat acagacaaca atcttgcagt    300

ctacgacctc tctcgggata ttttaaataa tttcccacac tcaatagcca ggcagaagcg    360

aatattggta aacctcagta tggtggaaaa caagctggtt gaactggaac atactctact    420

tagcaagggt ttcagaggtg catcacctca ccggaaatcc acctaaaagc gtacaggatg    480

taatgccagt ggtggaaatc attaaagaca ctttgagtag atccaaaaaa aaaaaaaaaa    540

aaaaaaaaaa aa                                                        552


<210>  4231
<211>  113
<212>  PRT
<213>  Homosapiens

<400>  4231

Met Asn Phe Tyr Leu Leu Leu Ala Ser Ser Ile Leu Cys Ala Leu Ile 
1               5                   10                  15      


Val Phe Trp Lys Tyr Arg Arg Phe Gln Arg Asn Thr Gly Glu Met Ser 
            20                  25                  30          


Ser Asn Ser Thr Ala Leu Ala Leu Val Arg Pro Ser Ser Ser Gly Leu 
        35                  40                  45              


Ile Asn Ser Asn Thr Asp Asn Asn Leu Ala Val Tyr Asp Leu Ser Arg 
    50                  55                  60                  


Asp Ile Leu Asn Asn Phe Pro His Ser Ile Ala Arg Gln Lys Arg Ile 
65                  70                  75                  80  


Leu Val Asn Leu Ser Met Val Glu Asn Lys Leu Val Glu Leu Glu His 
                85                  90                  95      


Thr Leu Leu Ser Lys Gly Phe Arg Gly Ala Ser Pro His Arg Lys Ser 
            100                 105                 110         


Thr 
    


<210>  4232
<211>  4154
<212>  DNA
<213>  Homosapiens

<400>  4232
gaaatctcgc gagggtaggt gcgcgtcggt attttgcggg caactagctc ttccagctgc     60

tgtaaattgc tgctgcggga gaaactggag ccgctgtagc cggcgcgccc ttcttccctt    120

actgcgagga gccaccgcct ctttcgcgct ccttatacac ctatcactgg gagcggtggc    180

agcaacattc cctggaccaa ccgccgcctc ttcaggcggc cgctttgccg gtcattcccg    240

aagcccggca actgagggcg gccccctttc cttaacagtc tcctcgctac agatcgtctg    300

ctccctcagc ctcgcccgag acccacttcc ccagtctcgc ccgggtggag gtcgacgagg    360

aggagacaag agtcaccctt cctccaggcg gcgccggccc cctcacccgc gggtgtgtcc    420

tataaatggc gtcggaaagc gacaccgagg aattctatga tgcccctgaa gatgtgcacc    480

tagggggcgg ctaccccgtg gggtctccag gaaaagttgg gctttcaaca ttcaaggaaa    540

cagagaacac tgcatacaaa gttggaaatg agtcccctgt acaagaattg aaacaagatg    600

tgtctaaaaa gattattgaa agtattattg aggagagtca gaaagtacta cagcttgaag    660

atgactcttt ggattccaaa ggaaaagaac tctctgatca agctactgcc agtcctattg    720

tggctagaac agatctgagc aatatacccg gactgttagc catagatcaa gtactaccgg    780

aagaatccca aaaggcagag agtcagaata catttgaaga gactgaatta gaattaaaaa    840

aatgctttcc ttctgatgaa acctgtgaga aaccagtaga tgaaaccacg aagttaactc    900

aaacaagttc aactgagcag cttaatgtgc ttgaaactga aacagaagta ttgaacaagg    960

aagcagtgga agtcaaagga ggtggtgatg ttttagagcc tgtgtcctca gactccttat   1020

ctactaaaga ttttgccgct gtggaagaag tggcccctgc caaaccccca agacacctta   1080

ctccagagcc tgatatagtg gctagtacaa agaagcctgt tccagcacgc ccacctcctc   1140

caactaattt cccacctcct agacccccac ctccttctcg acctgctcca ccaccaagaa   1200

aaaggaaaag cgaattggaa tttgagactc tgaaaactcc tgatatagat gttcccaaag   1260

agaatattac gtctgattct ctcctaaccg caagcatggc ttcagaaagt acggttaagg   1320

attctcagcc ttctcttgat ttggcaagtg ctaccagtgg agataaaata gttaccgccc   1380

aggaaaatgg aaaagcacct gatgggcaga ctgtagcagg tgaagtgatg ggccctcaga   1440

gacctagatc caactctggg agagagctta ctgatgagga aattttagcc agtgtaatga   1500

ttaagaacct ggatactgga gaagaaatac ctttgagtct tgcagaagag aaactaccaa   1560

caggcattaa tcctctcact ctacacatca tgagaaggac aaaagaatat gtaagtaatg   1620

acgcggcaca gtcagatgat gaagagaagt tacagtctca gccaacagat actgatggtg   1680

gaaggttaaa acagaaaacg actcaactaa agaagtttct tggaaaatca gtaaagagag   1740

caaagcacct tgctgaggaa tatggtgaac gtgctataaa taaagttaaa agtgttagag   1800

atgaagtgtt tcatactgat caagatgatc cttcatcaag tgatgatgaa ggaatgccat   1860

acacaagacc agttaaattc aaagcagcac acggtttcaa aggaccttat gattttgatc   1920

agatcaaagt ggtgcaagat cttagtggtg aacatatggg agctgtttgg accatgaaat   1980

tttctcactg tggccgatta cttgcctcag ctggacaaga caatgtagtg agaatatggg   2040

ctttaaaaaa tgcttttgac tatttcaaca atatgcgaat gaaatacaat actgaaggac   2100

gtgtgtcccc atcaccctct caggaaagtc taagttcatc aaaatcggat acagatacag   2160

gggtatgcag tggaactgat gaagaccctg atgataaaaa cgcacccttt cggcaacggc   2220

cattttgcaa atataaagga catactgctg atctccttga tctttcatgg tctaaaaact   2280

actttcttct ttcttcttca atggataaaa cagtcagatt atggcacatt tctcgaagag   2340

aatgcctttg ctgttttcaa catatagatt ttgtcactgc catagctttt catccaagag   2400

atgacaggta ttttctaagt gggtctttgg atggaaagct ccgcctttgg aacatacctg   2460

acaaaaaagt ggctttgtgg aatgaagtag atggtcagac aaaattgatc acagctgcaa   2520

atttctgtca gaatggcaaa tatgcagtga ttgggacata tgatggcaga tgtattttct   2580

atgatacaga gcatttgaaa taccatacac aaatacatgt ccgatctact agagggcgca   2640

acaaggttgg aagaaaaatt actggcattg agcctttacc tggagaaaat aagatattgg   2700

taacctcaaa tgactccaga atcagactat atgatttgag agatttgtca ctatccatga   2760

agtataaggg ttacgtcaat agcagcagcc agatcaaagc aagtttcagc catgatttta   2820

cttacctcgt tagtggttca gaagataagt atgtttatat ctggagtacc taccatgacc   2880

taagcaagtt tacttcagtc aggagagatc gtaatgactt ctgggaaggt attaaagccc   2940

acaatgcagt tgttacatca gccatctttg caccaaaccc aagtttgatg ttatctttgg   3000

atgtgcaatc tgaaaaatca gaagggaacg agaaaagtga agatgctgaa gttttggatg   3060

ccacaccttc tggtattatg aagacagata acacagaagt tcttctctct gctgacttca   3120

ctggagcaat caaagtgttt gttaataaaa gaaaaaatgt atcttaattt gaaatggcat   3180

ttaaaataaa catatcagta agtttctata tgtatcaaaa ctgaaaaaat agtgttccag   3240

gctaacatac ttttttaatt tttattgaaa gttgttcaaa tataatatat tttttgagag   3300

gcagtgttaa tgatctagga aaccctgggc tgatagagta gaaaggaata tggctagaat   3360

aacattgcca aacattaggc tttatgtttt gttatgtttg tgttttcgtt gtataattat   3420

gaacatgcac aagtttctgc atgaaaagat attaatatat taatcacatg tatgtgcctt   3480

ttggttacat gcattaaatc taacagagtt aaattatttc agtggctctt ttggcctctt   3540

actagggggg atagtcttgt ttctagctta aacaattttt tttttgcaca aaatttcatt   3600

tttaataaaa gtggtatctt ttgactgagt tattgttttg aaaatggtat ataggtttcc   3660

agtaggtcaa caaccatatg taaatggttt ttataaattt ctcaatttgg ggacaagatt   3720

tttttgtggt ctaaattgtg ggcttaagat tcttttcttt atatgtgtac atataatttt   3780

tttttctttg ccacactgga gcacaatgtt tctatgtaaa gaattatttt cattctttat   3840

ccatgagcac caggctttgc tcacttaaaa aaaaattaag ccacattaag gagtgagtct   3900

tcttttttac aataatgtaa aaattaaact gtttacattt ttttaaagca ttgtagtttt   3960

taaaaattaa gctgttttgt tttgtgttgt tgaatttgaa agcctttgta aatatcaata   4020

taatgtacca atgaaataac atctggggca atgaaaccct gatcatgttg ttgatggtta   4080

gcatatgttt ctgaaaatta aatatgtatt attaaaagtt ggtctccaac acttgtttaa   4140

aaaaaaaaaa aaaa                                                     4154


<210>  4233
<211>  913
<212>  PRT
<213>  Homosapiens

<400>  4233

Met Ala Ser Glu Ser Asp Thr Glu Glu Phe Tyr Asp Ala Pro Glu Asp 
1               5                   10                  15      


Val His Leu Gly Gly Gly Tyr Pro Val Gly Ser Pro Gly Lys Val Gly 
            20                  25                  30          


Leu Ser Thr Phe Lys Glu Thr Glu Asn Thr Ala Tyr Lys Val Gly Asn 
        35                  40                  45              


Glu Ser Pro Val Gln Glu Leu Lys Gln Asp Val Ser Lys Lys Ile Ile 
    50                  55                  60                  


Glu Ser Ile Ile Glu Glu Ser Gln Lys Val Leu Gln Leu Glu Asp Asp 
65                  70                  75                  80  


Ser Leu Asp Ser Lys Gly Lys Glu Leu Ser Asp Gln Ala Thr Ala Ser 
                85                  90                  95      


Pro Ile Val Ala Arg Thr Asp Leu Ser Asn Ile Pro Gly Leu Leu Ala 
            100                 105                 110         


Ile Asp Gln Val Leu Pro Glu Glu Ser Gln Lys Ala Glu Ser Gln Asn 
        115                 120                 125             


Thr Phe Glu Glu Thr Glu Leu Glu Leu Lys Lys Cys Phe Pro Ser Asp 
    130                 135                 140                 


Glu Thr Cys Glu Lys Pro Val Asp Glu Thr Thr Lys Leu Thr Gln Thr 
145                 150                 155                 160 


Ser Ser Thr Glu Gln Leu Asn Val Leu Glu Thr Glu Thr Glu Val Leu 
                165                 170                 175     


Asn Lys Glu Ala Val Glu Val Lys Gly Gly Gly Asp Val Leu Glu Pro 
            180                 185                 190         


Val Ser Ser Asp Ser Leu Ser Thr Lys Asp Phe Ala Ala Val Glu Glu 
        195                 200                 205             


Val Ala Pro Ala Lys Pro Pro Arg His Leu Thr Pro Glu Pro Asp Ile 
    210                 215                 220                 


Val Ala Ser Thr Lys Lys Pro Val Pro Ala Arg Pro Pro Pro Pro Thr 
225                 230                 235                 240 


Asn Phe Pro Pro Pro Arg Pro Pro Pro Pro Ser Arg Pro Ala Pro Pro 
                245                 250                 255     


Pro Arg Lys Arg Lys Ser Glu Leu Glu Phe Glu Thr Leu Lys Thr Pro 
            260                 265                 270         


Asp Ile Asp Val Pro Lys Glu Asn Ile Thr Ser Asp Ser Leu Leu Thr 
        275                 280                 285             


Ala Ser Met Ala Ser Glu Ser Thr Val Lys Asp Ser Gln Pro Ser Leu 
    290                 295                 300                 


Asp Leu Ala Ser Ala Thr Ser Gly Asp Lys Ile Val Thr Ala Gln Glu 
305                 310                 315                 320 


Asn Gly Lys Ala Pro Asp Gly Gln Thr Val Ala Gly Glu Val Met Gly 
                325                 330                 335     


Pro Gln Arg Pro Arg Ser Asn Ser Gly Arg Glu Leu Thr Asp Glu Glu 
            340                 345                 350         


Ile Leu Ala Ser Val Met Ile Lys Asn Leu Asp Thr Gly Glu Glu Ile 
        355                 360                 365             


Pro Leu Ser Leu Ala Glu Glu Lys Leu Pro Thr Gly Ile Asn Pro Leu 
    370                 375                 380                 


Thr Leu His Ile Met Arg Arg Thr Lys Glu Tyr Val Ser Asn Asp Ala 
385                 390                 395                 400 


Ala Gln Ser Asp Asp Glu Glu Lys Leu Gln Ser Gln Pro Thr Asp Thr 
                405                 410                 415     


Asp Gly Gly Arg Leu Lys Gln Lys Thr Thr Gln Leu Lys Lys Phe Leu 
            420                 425                 430         


Gly Lys Ser Val Lys Arg Ala Lys His Leu Ala Glu Glu Tyr Gly Glu 
        435                 440                 445             


Arg Ala Ile Asn Lys Val Lys Ser Val Arg Asp Glu Val Phe His Thr 
    450                 455                 460                 


Asp Gln Asp Asp Pro Ser Ser Ser Asp Asp Glu Gly Met Pro Tyr Thr 
465                 470                 475                 480 


Arg Pro Val Lys Phe Lys Ala Ala His Gly Phe Lys Gly Pro Tyr Asp 
                485                 490                 495     


Phe Asp Gln Ile Lys Val Val Gln Asp Leu Ser Gly Glu His Met Gly 
            500                 505                 510         


Ala Val Trp Thr Met Lys Phe Ser His Cys Gly Arg Leu Leu Ala Ser 
        515                 520                 525             


Ala Gly Gln Asp Asn Val Val Arg Ile Trp Ala Leu Lys Asn Ala Phe 
    530                 535                 540                 


Asp Tyr Phe Asn Asn Met Arg Met Lys Tyr Asn Thr Glu Gly Arg Val 
545                 550                 555                 560 


Ser Pro Ser Pro Ser Gln Glu Ser Leu Ser Ser Ser Lys Ser Asp Thr 
                565                 570                 575     


Asp Thr Gly Val Cys Ser Gly Thr Asp Glu Asp Pro Asp Asp Lys Asn 
            580                 585                 590         


Ala Pro Phe Arg Gln Arg Pro Phe Cys Lys Tyr Lys Gly His Thr Ala 
        595                 600                 605             


Asp Leu Leu Asp Leu Ser Trp Ser Lys Asn Tyr Phe Leu Leu Ser Ser 
    610                 615                 620                 


Ser Met Asp Lys Thr Val Arg Leu Trp His Ile Ser Arg Arg Glu Cys 
625                 630                 635                 640 


Leu Cys Cys Phe Gln His Ile Asp Phe Val Thr Ala Ile Ala Phe His 
                645                 650                 655     


Pro Arg Asp Asp Arg Tyr Phe Leu Ser Gly Ser Leu Asp Gly Lys Leu 
            660                 665                 670         


Arg Leu Trp Asn Ile Pro Asp Lys Lys Val Ala Leu Trp Asn Glu Val 
        675                 680                 685             


Asp Gly Gln Thr Lys Leu Ile Thr Ala Ala Asn Phe Cys Gln Asn Gly 
    690                 695                 700                 


Lys Tyr Ala Val Ile Gly Thr Tyr Asp Gly Arg Cys Ile Phe Tyr Asp 
705                 710                 715                 720 


Thr Glu His Leu Lys Tyr His Thr Gln Ile His Val Arg Ser Thr Arg 
                725                 730                 735     


Gly Arg Asn Lys Val Gly Arg Lys Ile Thr Gly Ile Glu Pro Leu Pro 
            740                 745                 750         


Gly Glu Asn Lys Ile Leu Val Thr Ser Asn Asp Ser Arg Ile Arg Leu 
        755                 760                 765             


Tyr Asp Leu Arg Asp Leu Ser Leu Ser Met Lys Tyr Lys Gly Tyr Val 
    770                 775                 780                 


Asn Ser Ser Ser Gln Ile Lys Ala Ser Phe Ser His Asp Phe Thr Tyr 
785                 790                 795                 800 


Leu Val Ser Gly Ser Glu Asp Lys Tyr Val Tyr Ile Trp Ser Thr Tyr 
                805                 810                 815     


His Asp Leu Ser Lys Phe Thr Ser Val Arg Arg Asp Arg Asn Asp Phe 
            820                 825                 830         


Trp Glu Gly Ile Lys Ala His Asn Ala Val Val Thr Ser Ala Ile Phe 
        835                 840                 845             


Ala Pro Asn Pro Ser Leu Met Leu Ser Leu Asp Val Gln Ser Glu Lys 
    850                 855                 860                 


Ser Glu Gly Asn Glu Lys Ser Glu Asp Ala Glu Val Leu Asp Ala Thr 
865                 870                 875                 880 


Pro Ser Gly Ile Met Lys Thr Asp Asn Thr Glu Val Leu Leu Ser Ala 
                885                 890                 895     


Asp Phe Thr Gly Ala Ile Lys Val Phe Val Asn Lys Arg Lys Asn Val 
            900                 905                 910         


Ser 
    


<210>  4234
<211>  6639
<212>  DNA
<213>  Homosapiens

<400>  4234
ggcagtgagt ccacccgccc gccgaggtcc gcccgcccgc cgagacccgc ccgccgccgc     60

tgccatggcc gaagtgcgca aattcaccaa acggctcagc aagcctggca cggcggctga    120

gctccggcag agcgtgtctg aggccgtgcg gggctccgtg gtgctggaaa aggccaaagt    180

tgttgagccc ctggactatg agaatgttat tgcccaaaga aaaacccaga tttacagcga    240

ccccctccga gatctgctta tgttcccaat ggaagatata tctatctcgg tgataggtcg    300

tcaacgcaga acggtgcagt ctactgtacc agaagatgct gaaaagaggg cccagagttt    360

atttgttaaa gagtgtatta aaacctatag cacagattgg cacgtggtaa actacaagta    420

tgaggacttc tctggggact ttcgaatgtt gccatgtaaa tctttgagac cagaaaagat    480

tcctaatcat gtatttgaga tagatgaaga ctgtgagaaa gatgaggact catcttcttt    540

atgttctcag aagggtggtg tgataaaaca aggctggttg cataaagcaa atgtaaatag    600

taccatcaca gtaaccatga aggtattcaa gagacgatat ttttacttga cccaacttcc    660

tgacggttca tatattctca attcctataa agatgagaaa aattcaaaag aatcgaaagg    720

ttgcatctac ttggacgcct gcattgatgt tgttcagtgc cccaaaatgc gccgtcatgc    780

ttttgaactc aagatgttag ataaatatag ccattatctg gctgctgaaa ctgagcagga    840

aatggaggaa tggttgataa ctttgaaaaa gattattcag atcaacaccg acagtttagt    900

tcaagaaaaa aaggagacgg tagaaacagc acaagatgat gaaactagca gccaaggaaa    960

agccgagaac atcatggcaa gtttggaaag gagcatgcat ccggaactga tgaagtatgg   1020

aagagaaact gaacaactaa acaaactcag tagaggagat ggaagacaga atctcttttc   1080

ttttgattca gaagttcaga ggttggactt ttcaggaatt gaacctgata taaagccatt   1140

tgaagaaaaa tgcaataaac gtttcctggt gaattgccat gatttaactt tcaatatctt   1200

gggccaaatt ggagacaatg caaaaggacc acccacaaat gttgagccct tttttatcaa   1260

tcttgcctta tttgatgtaa agaacaattg taagatttca gcagactttc atgtagacct   1320

gaatccccca tctgtccgtg aaatgctgtg gggctcttca acccaactgg ccagtgacgg   1380

tagcccaaag ggctcttcac ccgaatctta cattcatgga attgccgaat ctcagttacg   1440

ctacatacaa cagggaattt tctcagtgac gaatccacat cctgaaattt ttctagttgc   1500

cagaattgaa aaggtactac agggaaacat tacacactgt gcagaaccct atatcaaaaa   1560

ttctgatcca gtaaagacgg cccagaaggt gcacaggaca gctaaacaag tgtgtagccg   1620

ccttggacaa tacagaatgc ccttcgcttg ggctgccaga cccattttca aagatactca   1680

aggctctctt gatctggatg ggagattttc tcctctgtat aaacaagaca gtagcaagct   1740

ttcaagtgaa gacattctca agttgctctc agaatataag aagccagaaa agaccaaact   1800

gcagattatt cctgggcagc taaacatcac agtagaatgt gttcctgtgg atttatcaaa   1860

ttgtattact tcttcatatg tgcccttgaa gccttttgaa aagaattgcc aaaatattac   1920

tgtggaggtt gaagagtttg ttccagaaat gacaaaatat tgttatccat ttactattta   1980

caaaaaccat ctgtatgtat atcccctgca attaaaatac gatagccaga aaacatttgc   2040

caaggcaagg aacattgcag tctgtgtgga attccgggat tcagatgaaa gtgacgctag   2100

tgccctaaag tgtatttatg gaaaacctgc agggtctgtt tttaccacaa atgcttatgc   2160

tgttgtctcg catcacaacc aaaatccaga gttctatgat gagattaaaa ttgagcttcc   2220

cattcaccta catcaaaaac atcgtttgct tttcactttt tatcatgtaa gttgtgaaat   2280

taacacaaag ggaacaacca aaaagcaaga cacagttgaa actccagttg ggtttgcctg   2340

ggtacctttg ctgaaagatg gtagaatcat cacatttgag cagcagctgc cagtttccgc   2400

caatcttccc ccaggctact tgaatctgaa tgatgcagaa tcaagaaggc aatgtaacgt   2460

ggatattaaa tgggtagatg gtgcaaagcc tttgttgaag attaaaagcc acttagaatc   2520

taccatttac actcaagatc tgcatgtgca caaattcttc catcattgcc agctgattca   2580

gtcaggctcg aaagaagttc caggggagct cattaaatat ttaaagtgtt tgcatgccat   2640

ggagatccaa gtcatgatac agtttctacc tgtaattctt atgcaactct tccgagttct   2700

cacaaatatg acccatgaag atgacgttcc tatcaactgc accatggttc tcttacatat   2760

tgtatcaaag tgccatgaag aaggcttgga tagttatcta agatcattca taaagtatag   2820

cttccgacct gaaaaaccga gtgctcctca ggcccagctg atacatgaaa ccctggctac   2880

tacgatgata gcaatattga aacagtctgc agatttttta tcaataaaca aattgctaaa   2940

gtactcatgg tttttctttg aaataattgc aaagtcaatg gccacatact tgttggaaga   3000

gaataagatt aagcttcccc gaggccagag atttcccgag acatatcatc atgtcttaca   3060

ttcactgctt cttgcaataa ttccccatgt gactattcgg tatgcggaga ttcccgatga   3120

gtccagaaat gtgaactata gtttggctag cttcctgaag cgctgtttga cactaatgga   3180

tagaggattt attttcaatt taataaatga ctatatatct ggattcagcc ccaaagatcc   3240

taaggttctg gctgaataca agtttgaatt tctgcaaaca atttgcaatc acgaacatta   3300

cattcctctg aacttgccaa tggcatttgc aaaacctaaa ctgcagcggg ttcaagattc   3360

aaatcttgaa tacagtttat cagatgagta ttgcaagcat cacttcttgg ttggtctact   3420

tctgagggaa acttccattg ctcttcagga caattatgag atcagatata cagctatctc   3480

tgttataaag aatcttttga taaaacatgc atttgacaca agataccagc acaagaacca   3540

acaagccaaa atagcacaat tgtacctccc ctttgttgga ctacttttgg aaaatataca   3600

gcgattagca ggtcgagata ccttgtattc ttgtgcagcc atgcctaatt ctgcatccag   3660

agatgagttt ccatgtggct ttacttcacc tgccaataga gggagtctga gcactgacaa   3720

agacaccgct tatgggtctt ttcaaaatgg acatggaatt aagagagaag attcaagagg   3780

ttccctcatc ccagaaggag caacaggatt tccagatcag ggcaacactg gtgaaaatac   3840

ccgacagagt tctacaagga gtagtgtatc ccagtataac cgcctggatc agtatgaaat   3900

cagaagcctc ctgatgtgct acctgtatat agtaaaaatg atttcagaag atactctctt   3960

aacttactgg aataaagtat cacctcagga gctcataaac attcttatac ttttagaagt   4020

atgcttgttt cactttagat atatggggaa aagaaacata gcaagggtgc atgatgcctg   4080

gctgtcaaaa cacttcggaa tagaccgaaa atcgcaaacc atgcctgctc ttcgaaacag   4140

atcaggagta atgcaggccc ggcttcagca tcttagtagc ctagaaagtt catttacact   4200

taatcacagt tctacaacaa ctgaagcaga cattttccac caggcacttc ttgaaggcaa   4260

tacagctact gaagtttccc taacagtact agacaccata tcatttttca ctcagtgctt   4320

caagacccaa cttttaaata atgatggcca taacccatta atgaaaaaag tgtttgatat   4380

acatcttgct tttcttaaaa atggacaatc tgaagtgtcg ctgaaacatg tatttgcctc   4440

actgagagct ttcatcagta agtttccttc agcatttttc aaaggaagag taaacatgtg   4500

tgctgcattt tgctatgagg ttttaaagtg ctgcacatcg aagattagct caaccaggaa   4560

tgaagcatct gcacttttgt atcttttgat gagaaacaac tttgagtata ccaaaaggaa   4620

aacctttttg aggacacatc tacagataat aattgctgta agccaactga tagctgatgt   4680

agcactaagc ggaggatcaa gatttcagga gtctttattc attatcaata attttgcaaa   4740

tagtgacaga cctatgaagg caactgcctt tcccgcagaa gtcaaagact tgaccaagag   4800

aatccgcact gttcttatgg ccactgccca aatgaaggag catgagaaag accctgaaat   4860

gctaattgat ctccagtata gcttagccaa gtcctatgca agcaccccag agctcaggaa   4920

aacctggctt gatagcatgg ccaagattca tgtaaaaaat ggagattttt cagaggctgc   4980

gatgtgttat gtccatgtag cagctctagt tgcagagttt cttcatcgaa aaaaattatt   5040

tcctaacgga tgttcagcgt tcaagaaaat tactcccaat atagatgaag aaggagcaat   5100

gaaagaagat gctgggatga tggatgtcca ttatagtgaa gaggtcttgc tggagttgct   5160

agaacaatgt gtggatggct tatggaaggc agaacgttat gaaataattt ctgagatttc   5220

caagttgatc gttccaattt atgagaaacg tcgtgagttt gagaaactta ctcaagttta   5280

tagaactctt catggagctt acacaaaaat tctggaagtt atgcatacaa aaaagagact   5340

tttaggcact ttcttcagag ttgcctttta tggccaatct ttttttgaag aagaagatgg   5400

aaaggagtac atctataaag aaccaaagct cactggcctc tcagaaattt ccttgagact   5460

tgttaaactt tatggtgaaa agtttggtac ggagaatgtc aaaataattc aggattcaga   5520

caaggtaaat gccaaagagc ttgatccaaa atatgctcat atacaagtta cttatgtgaa   5580

gccttacttt gatgacaaag aactcacaga aaggaagacc gagtttgaaa gaaatcataa   5640

tatcagcaga tttgtttttg aggcccctta cactttatca ggcaaaaaac agggctgtat   5700

agaagaacag tgcaaacgcc gtacaatctt gacaacttca aactcgtttc cttacgtgaa   5760

gaagaggatt cctattaact gtgaacagca gattaattta aaaccaattg atgttgccac   5820

tgatgaaata aaagataaaa ctgcagagct gcaaaagctt tgctcctcta ctgacgtgga   5880

catgattcag ctccaactta aattgcaggg ctgtgtttct gtgcaggtca atgctggtcc   5940

attagcatat gcaagagctt tcttaaatga cagccaagct agcaagtatc cacctaagaa   6000

agtgagtgag ttgaaagaca tgtttaggaa atttatacaa gcatgcagca ttgcacttga   6060

actaaatgag cggctaatta aagaagatca agttgagtac catgaagggc taaagtcaaa   6120

tttcagagac atggtaaaag aattatctga cattatccat gagcagatat tacaagaaga   6180

cacaatgcat tctccctgga tgagcaacac attacatgta ttttgtgcaa ttagtggtac   6240

atcaagtgac cgaggttatg gttccccaag atacgctgaa gtgtgaggaa atgcagatgt   6300

acgtgacaat gagactgacc tttctcagga atatttggag ctgtgcaaat gttaaaattt   6360

aaagatttga tatacatgga gtgtttcttc tcgacaccaa aattttcatg tgttccaaca   6420

gggtgcttac atatttgtaa ataagcaact tgaaagtgcc tggaaaattg caccactgtg   6480

cttggtttgt acttttttag gtaaatctat atgctgaaaa gtagagctca aaaacagtag   6540

ttcaatttgc ttaattattg cttaaaataa tggtactatg taaaattgta taatggaata   6600

caataaaagg taaaacttat ttgtaaaaaa aaaaaaaaa                          6639


<210>  4235
<211>  2073
<212>  PRT
<213>  Homosapiens

<400>  4235

Met Ala Glu Val Arg Lys Phe Thr Lys Arg Leu Ser Lys Pro Gly Thr 
1               5                   10                  15      


Ala Ala Glu Leu Arg Gln Ser Val Ser Glu Ala Val Arg Gly Ser Val 
            20                  25                  30          


Val Leu Glu Lys Ala Lys Val Val Glu Pro Leu Asp Tyr Glu Asn Val 
        35                  40                  45              


Ile Ala Gln Arg Lys Thr Gln Ile Tyr Ser Asp Pro Leu Arg Asp Leu 
    50                  55                  60                  


Leu Met Phe Pro Met Glu Asp Ile Ser Ile Ser Val Ile Gly Arg Gln 
65                  70                  75                  80  


Arg Arg Thr Val Gln Ser Thr Val Pro Glu Asp Ala Glu Lys Arg Ala 
                85                  90                  95      


Gln Ser Leu Phe Val Lys Glu Cys Ile Lys Thr Tyr Ser Thr Asp Trp 
            100                 105                 110         


His Val Val Asn Tyr Lys Tyr Glu Asp Phe Ser Gly Asp Phe Arg Met 
        115                 120                 125             


Leu Pro Cys Lys Ser Leu Arg Pro Glu Lys Ile Pro Asn His Val Phe 
    130                 135                 140                 


Glu Ile Asp Glu Asp Cys Glu Lys Asp Glu Asp Ser Ser Ser Leu Cys 
145                 150                 155                 160 


Ser Gln Lys Gly Gly Val Ile Lys Gln Gly Trp Leu His Lys Ala Asn 
                165                 170                 175     


Val Asn Ser Thr Ile Thr Val Thr Met Lys Val Phe Lys Arg Arg Tyr 
            180                 185                 190         


Phe Tyr Leu Thr Gln Leu Pro Asp Gly Ser Tyr Ile Leu Asn Ser Tyr 
        195                 200                 205             


Lys Asp Glu Lys Asn Ser Lys Glu Ser Lys Gly Cys Ile Tyr Leu Asp 
    210                 215                 220                 


Ala Cys Ile Asp Val Val Gln Cys Pro Lys Met Arg Arg His Ala Phe 
225                 230                 235                 240 


Glu Leu Lys Met Leu Asp Lys Tyr Ser His Tyr Leu Ala Ala Glu Thr 
                245                 250                 255     


Glu Gln Glu Met Glu Glu Trp Leu Ile Thr Leu Lys Lys Ile Ile Gln 
            260                 265                 270         


Ile Asn Thr Asp Ser Leu Val Gln Glu Lys Lys Glu Thr Val Glu Thr 
        275                 280                 285             


Ala Gln Asp Asp Glu Thr Ser Ser Gln Gly Lys Ala Glu Asn Ile Met 
    290                 295                 300                 


Ala Ser Leu Glu Arg Ser Met His Pro Glu Leu Met Lys Tyr Gly Arg 
305                 310                 315                 320 


Glu Thr Glu Gln Leu Asn Lys Leu Ser Arg Gly Asp Gly Arg Gln Asn 
                325                 330                 335     


Leu Phe Ser Phe Asp Ser Glu Val Gln Arg Leu Asp Phe Ser Gly Ile 
            340                 345                 350         


Glu Pro Asp Ile Lys Pro Phe Glu Glu Lys Cys Asn Lys Arg Phe Leu 
        355                 360                 365             


Val Asn Cys His Asp Leu Thr Phe Asn Ile Leu Gly Gln Ile Gly Asp 
    370                 375                 380                 


Asn Ala Lys Gly Pro Pro Thr Asn Val Glu Pro Phe Phe Ile Asn Leu 
385                 390                 395                 400 


Ala Leu Phe Asp Val Lys Asn Asn Cys Lys Ile Ser Ala Asp Phe His 
                405                 410                 415     


Val Asp Leu Asn Pro Pro Ser Val Arg Glu Met Leu Trp Gly Ser Ser 
            420                 425                 430         


Thr Gln Leu Ala Ser Asp Gly Ser Pro Lys Gly Ser Ser Pro Glu Ser 
        435                 440                 445             


Tyr Ile His Gly Ile Ala Glu Ser Gln Leu Arg Tyr Ile Gln Gln Gly 
    450                 455                 460                 


Ile Phe Ser Val Thr Asn Pro His Pro Glu Ile Phe Leu Val Ala Arg 
465                 470                 475                 480 


Ile Glu Lys Val Leu Gln Gly Asn Ile Thr His Cys Ala Glu Pro Tyr 
                485                 490                 495     


Ile Lys Asn Ser Asp Pro Val Lys Thr Ala Gln Lys Val His Arg Thr 
            500                 505                 510         


Ala Lys Gln Val Cys Ser Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala 
        515                 520                 525             


Trp Ala Ala Arg Pro Ile Phe Lys Asp Thr Gln Gly Ser Leu Asp Leu 
    530                 535                 540                 


Asp Gly Arg Phe Ser Pro Leu Tyr Lys Gln Asp Ser Ser Lys Leu Ser 
545                 550                 555                 560 


Ser Glu Asp Ile Leu Lys Leu Leu Ser Glu Tyr Lys Lys Pro Glu Lys 
                565                 570                 575     


Thr Lys Leu Gln Ile Ile Pro Gly Gln Leu Asn Ile Thr Val Glu Cys 
            580                 585                 590         


Val Pro Val Asp Leu Ser Asn Cys Ile Thr Ser Ser Tyr Val Pro Leu 
        595                 600                 605             


Lys Pro Phe Glu Lys Asn Cys Gln Asn Ile Thr Val Glu Val Glu Glu 
    610                 615                 620                 


Phe Val Pro Glu Met Thr Lys Tyr Cys Tyr Pro Phe Thr Ile Tyr Lys 
625                 630                 635                 640 


Asn His Leu Tyr Val Tyr Pro Leu Gln Leu Lys Tyr Asp Ser Gln Lys 
                645                 650                 655     


Thr Phe Ala Lys Ala Arg Asn Ile Ala Val Cys Val Glu Phe Arg Asp 
            660                 665                 670         


Ser Asp Glu Ser Asp Ala Ser Ala Leu Lys Cys Ile Tyr Gly Lys Pro 
        675                 680                 685             


Ala Gly Ser Val Phe Thr Thr Asn Ala Tyr Ala Val Val Ser His His 
    690                 695                 700                 


Asn Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Ile 
705                 710                 715                 720 


His Leu His Gln Lys His Arg Leu Leu Phe Thr Phe Tyr His Val Ser 
                725                 730                 735     


Cys Glu Ile Asn Thr Lys Gly Thr Thr Lys Lys Gln Asp Thr Val Glu 
            740                 745                 750         


Thr Pro Val Gly Phe Ala Trp Val Pro Leu Leu Lys Asp Gly Arg Ile 
        755                 760                 765             


Ile Thr Phe Glu Gln Gln Leu Pro Val Ser Ala Asn Leu Pro Pro Gly 
    770                 775                 780                 


Tyr Leu Asn Leu Asn Asp Ala Glu Ser Arg Arg Gln Cys Asn Val Asp 
785                 790                 795                 800 


Ile Lys Trp Val Asp Gly Ala Lys Pro Leu Leu Lys Ile Lys Ser His 
                805                 810                 815     


Leu Glu Ser Thr Ile Tyr Thr Gln Asp Leu His Val His Lys Phe Phe 
            820                 825                 830         


His His Cys Gln Leu Ile Gln Ser Gly Ser Lys Glu Val Pro Gly Glu 
        835                 840                 845             


Leu Ile Lys Tyr Leu Lys Cys Leu His Ala Met Glu Ile Gln Val Met 
    850                 855                 860                 


Ile Gln Phe Leu Pro Val Ile Leu Met Gln Leu Phe Arg Val Leu Thr 
865                 870                 875                 880 


Asn Met Thr His Glu Asp Asp Val Pro Ile Asn Cys Thr Met Val Leu 
                885                 890                 895     


Leu His Ile Val Ser Lys Cys His Glu Glu Gly Leu Asp Ser Tyr Leu 
            900                 905                 910         


Arg Ser Phe Ile Lys Tyr Ser Phe Arg Pro Glu Lys Pro Ser Ala Pro 
        915                 920                 925             


Gln Ala Gln Leu Ile His Glu Thr Leu Ala Thr Thr Met Ile Ala Ile 
    930                 935                 940                 


Leu Lys Gln Ser Ala Asp Phe Leu Ser Ile Asn Lys Leu Leu Lys Tyr 
945                 950                 955                 960 


Ser Trp Phe Phe Phe Glu Ile Ile Ala Lys Ser Met Ala Thr Tyr Leu 
                965                 970                 975     


Leu Glu Glu Asn Lys Ile Lys Leu Pro Arg Gly Gln Arg Phe Pro Glu 
            980                 985                 990         


Thr Tyr His His Val Leu His Ser  Leu Leu Leu Ala Ile  Ile Pro His 
        995                 1000                 1005             


Val Thr  Ile Arg Tyr Ala Glu  Ile Pro Asp Glu Ser  Arg Asn Val 
    1010                 1015                 1020             


Asn Tyr  Ser Leu Ala Ser Phe  Leu Lys Arg Cys Leu  Thr Leu Met 
    1025                 1030                 1035             


Asp Arg  Gly Phe Ile Phe Asn  Leu Ile Asn Asp Tyr  Ile Ser Gly 
    1040                 1045                 1050             


Phe Ser  Pro Lys Asp Pro Lys  Val Leu Ala Glu Tyr  Lys Phe Glu 
    1055                 1060                 1065             


Phe Leu  Gln Thr Ile Cys Asn  His Glu His Tyr Ile  Pro Leu Asn 
    1070                 1075                 1080             


Leu Pro  Met Ala Phe Ala Lys  Pro Lys Leu Gln Arg  Val Gln Asp 
    1085                 1090                 1095             


Ser Asn  Leu Glu Tyr Ser Leu  Ser Asp Glu Tyr Cys  Lys His His 
    1100                 1105                 1110             


Phe Leu  Val Gly Leu Leu Leu  Arg Glu Thr Ser Ile  Ala Leu Gln 
    1115                 1120                 1125             


Asp Asn  Tyr Glu Ile Arg Tyr  Thr Ala Ile Ser Val  Ile Lys Asn 
    1130                 1135                 1140             


Leu Leu  Ile Lys His Ala Phe  Asp Thr Arg Tyr Gln  His Lys Asn 
    1145                 1150                 1155             


Gln Gln  Ala Lys Ile Ala Gln  Leu Tyr Leu Pro Phe  Val Gly Leu 
    1160                 1165                 1170             


Leu Leu  Glu Asn Ile Gln Arg  Leu Ala Gly Arg Asp  Thr Leu Tyr 
    1175                 1180                 1185             


Ser Cys  Ala Ala Met Pro Asn  Ser Ala Ser Arg Asp  Glu Phe Pro 
    1190                 1195                 1200             


Cys Gly  Phe Thr Ser Pro Ala  Asn Arg Gly Ser Leu  Ser Thr Asp 
    1205                 1210                 1215             


Lys Asp  Thr Ala Tyr Gly Ser  Phe Gln Asn Gly His  Gly Ile Lys 
    1220                 1225                 1230             


Arg Glu  Asp Ser Arg Gly Ser  Leu Ile Pro Glu Gly  Ala Thr Gly 
    1235                 1240                 1245             


Phe Pro  Asp Gln Gly Asn Thr  Gly Glu Asn Thr Arg  Gln Ser Ser 
    1250                 1255                 1260             


Thr Arg  Ser Ser Val Ser Gln  Tyr Asn Arg Leu Asp  Gln Tyr Glu 
    1265                 1270                 1275             


Ile Arg  Ser Leu Leu Met Cys  Tyr Leu Tyr Ile Val  Lys Met Ile 
    1280                 1285                 1290             


Ser Glu  Asp Thr Leu Leu Thr  Tyr Trp Asn Lys Val  Ser Pro Gln 
    1295                 1300                 1305             


Glu Leu  Ile Asn Ile Leu Ile  Leu Leu Glu Val Cys  Leu Phe His 
    1310                 1315                 1320             


Phe Arg  Tyr Met Gly Lys Arg  Asn Ile Ala Arg Val  His Asp Ala 
    1325                 1330                 1335             


Trp Leu  Ser Lys His Phe Gly  Ile Asp Arg Lys Ser  Gln Thr Met 
    1340                 1345                 1350             


Pro Ala  Leu Arg Asn Arg Ser  Gly Val Met Gln Ala  Arg Leu Gln 
    1355                 1360                 1365             


His Leu  Ser Ser Leu Glu Ser  Ser Phe Thr Leu Asn  His Ser Ser 
    1370                 1375                 1380             


Thr Thr  Thr Glu Ala Asp Ile  Phe His Gln Ala Leu  Leu Glu Gly 
    1385                 1390                 1395             


Asn Thr  Ala Thr Glu Val Ser  Leu Thr Val Leu Asp  Thr Ile Ser 
    1400                 1405                 1410             


Phe Phe  Thr Gln Cys Phe Lys  Thr Gln Leu Leu Asn  Asn Asp Gly 
    1415                 1420                 1425             


His Asn  Pro Leu Met Lys Lys  Val Phe Asp Ile His  Leu Ala Phe 
    1430                 1435                 1440             


Leu Lys  Asn Gly Gln Ser Glu  Val Ser Leu Lys His  Val Phe Ala 
    1445                 1450                 1455             


Ser Leu  Arg Ala Phe Ile Ser  Lys Phe Pro Ser Ala  Phe Phe Lys 
    1460                 1465                 1470             


Gly Arg  Val Asn Met Cys Ala  Ala Phe Cys Tyr Glu  Val Leu Lys 
    1475                 1480                 1485             


Cys Cys  Thr Ser Lys Ile Ser  Ser Thr Arg Asn Glu  Ala Ser Ala 
    1490                 1495                 1500             


Leu Leu  Tyr Leu Leu Met Arg  Asn Asn Phe Glu Tyr  Thr Lys Arg 
    1505                 1510                 1515             


Lys Thr  Phe Leu Arg Thr His  Leu Gln Ile Ile Ile  Ala Val Ser 
    1520                 1525                 1530             


Gln Leu  Ile Ala Asp Val Ala  Leu Ser Gly Gly Ser  Arg Phe Gln 
    1535                 1540                 1545             


Glu Ser  Leu Phe Ile Ile Asn  Asn Phe Ala Asn Ser  Asp Arg Pro 
    1550                 1555                 1560             


Met Lys  Ala Thr Ala Phe Pro  Ala Glu Val Lys Asp  Leu Thr Lys 
    1565                 1570                 1575             


Arg Ile  Arg Thr Val Leu Met  Ala Thr Ala Gln Met  Lys Glu His 
    1580                 1585                 1590             


Glu Lys  Asp Pro Glu Met Leu  Ile Asp Leu Gln Tyr  Ser Leu Ala 
    1595                 1600                 1605             


Lys Ser  Tyr Ala Ser Thr Pro  Glu Leu Arg Lys Thr  Trp Leu Asp 
    1610                 1615                 1620             


Ser Met  Ala Lys Ile His Val  Lys Asn Gly Asp Phe  Ser Glu Ala 
    1625                 1630                 1635             


Ala Met  Cys Tyr Val His Val  Ala Ala Leu Val Ala  Glu Phe Leu 
    1640                 1645                 1650             


His Arg  Lys Lys Leu Phe Pro  Asn Gly Cys Ser Ala  Phe Lys Lys 
    1655                 1660                 1665             


Ile Thr  Pro Asn Ile Asp Glu  Glu Gly Ala Met Lys  Glu Asp Ala 
    1670                 1675                 1680             


Gly Met  Met Asp Val His Tyr  Ser Glu Glu Val Leu  Leu Glu Leu 
    1685                 1690                 1695             


Leu Glu  Gln Cys Val Asp Gly  Leu Trp Lys Ala Glu  Arg Tyr Glu 
    1700                 1705                 1710             


Ile Ile  Ser Glu Ile Ser Lys  Leu Ile Val Pro Ile  Tyr Glu Lys 
    1715                 1720                 1725             


Arg Arg  Glu Phe Glu Lys Leu  Thr Gln Val Tyr Arg  Thr Leu His 
    1730                 1735                 1740             


Gly Ala  Tyr Thr Lys Ile Leu  Glu Val Met His Thr  Lys Lys Arg 
    1745                 1750                 1755             


Leu Leu  Gly Thr Phe Phe Arg  Val Ala Phe Tyr Gly  Gln Ser Phe 
    1760                 1765                 1770             


Phe Glu  Glu Glu Asp Gly Lys  Glu Tyr Ile Tyr Lys  Glu Pro Lys 
    1775                 1780                 1785             


Leu Thr  Gly Leu Ser Glu Ile  Ser Leu Arg Leu Val  Lys Leu Tyr 
    1790                 1795                 1800             


Gly Glu  Lys Phe Gly Thr Glu  Asn Val Lys Ile Ile  Gln Asp Ser 
    1805                 1810                 1815             


Asp Lys  Val Asn Ala Lys Glu  Leu Asp Pro Lys Tyr  Ala His Ile 
    1820                 1825                 1830             


Gln Val  Thr Tyr Val Lys Pro  Tyr Phe Asp Asp Lys  Glu Leu Thr 
    1835                 1840                 1845             


Glu Arg  Lys Thr Glu Phe Glu  Arg Asn His Asn Ile  Ser Arg Phe 
    1850                 1855                 1860             


Val Phe  Glu Ala Pro Tyr Thr  Leu Ser Gly Lys Lys  Gln Gly Cys 
    1865                 1870                 1875             


Ile Glu  Glu Gln Cys Lys Arg  Arg Thr Ile Leu Thr  Thr Ser Asn 
    1880                 1885                 1890             


Ser Phe  Pro Tyr Val Lys Lys  Arg Ile Pro Ile Asn  Cys Glu Gln 
    1895                 1900                 1905             


Gln Ile  Asn Leu Lys Pro Ile  Asp Val Ala Thr Asp  Glu Ile Lys 
    1910                 1915                 1920             


Asp Lys  Thr Ala Glu Leu Gln  Lys Leu Cys Ser Ser  Thr Asp Val 
    1925                 1930                 1935             


Asp Met  Ile Gln Leu Gln Leu  Lys Leu Gln Gly Cys  Val Ser Val 
    1940                 1945                 1950             


Gln Val  Asn Ala Gly Pro Leu  Ala Tyr Ala Arg Ala  Phe Leu Asn 
    1955                 1960                 1965             


Asp Ser  Gln Ala Ser Lys Tyr  Pro Pro Lys Lys Val  Ser Glu Leu 
    1970                 1975                 1980             


Lys Asp  Met Phe Arg Lys Phe  Ile Gln Ala Cys Ser  Ile Ala Leu 
    1985                 1990                 1995             


Glu Leu  Asn Glu Arg Leu Ile  Lys Glu Asp Gln Val  Glu Tyr His 
    2000                 2005                 2010             


Glu Gly  Leu Lys Ser Asn Phe  Arg Asp Met Val Lys  Glu Leu Ser 
    2015                 2020                 2025             


Asp Ile  Ile His Glu Gln Ile  Leu Gln Glu Asp Thr  Met His Ser 
    2030                 2035                 2040             


Pro Trp  Met Ser Asn Thr Leu  His Val Phe Cys Ala  Ile Ser Gly 
    2045                 2050                 2055             


Thr Ser  Ser Asp Arg Gly Tyr  Gly Ser Pro Arg Tyr  Ala Glu Val 
    2060                 2065                 2070             


<210>  4236
<211>  4006
<212>  DNA
<213>  Homosapiens

<400>  4236
tgccaaggct ccagcccggc cgggctccga ggcgagaggc tgcatggagt ggccggcgcg     60

gctctgcggg ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc    120

cgcgcctacg gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg    180

cacagtaata tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta    240

ttttagtcat tttggcgaca aacaagataa gaaaatagct ccggaaactc gtcgttcaat    300

agaagtaccc ctgaatgaga ggatttgtct gcaagtgggg tcccagtgta gcaccaatga    360

gagtgagaag cctagcattt tggttgaaaa atgcatctca cccccagaag gtgatcctga    420

gtctgctgtg actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg    480

gctccctgga aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag    540

cctggaaaaa attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc    600

ctttgatctg accaaagtga aggattccag ttttgaacaa cacagtgtcc aaataatggt    660

caaggataat gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt    720

gaaacctgat cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca    780

atgggagaat ccacagaatt ttattagcag atgcctattt tatgaagtag aagtcaataa    840

cagccaaact gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga    900

atttgagaga aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac    960

tttgaacaca gtcagaataa gagtcaaaac aaataagtta tgctatgagg atgacaaact   1020

ctggagtaat tggagccaag aaatgagtat aggtaagaag cgcaattcca cactctacat   1080

aaccatgtta ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta   1140

cctaaaaagg ctcaagatta ttatattccc tccaattcct gatcctggca agatttttaa   1200

agaaatgttt ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga   1260

gaagcaaacc aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc   1320

tcagtgatgg agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt   1380

ctccatttgt tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa   1440

caggcagctc ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat   1500

aatgggcgct ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc   1560

ttcaaactag gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt   1620

tgtgacaact tcctgaggga tctatacttg ctttgtgttc tttgtgtcaa catgaacaaa   1680

ttttatttgt aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa   1740

gaacatgtag aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac   1800

catgtttgtg gctattaaaa ctcttttaac agtctgggct gggtccggtg gctcacgcct   1860

gtaatcccag caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga   1920

ccagcctgac caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg   1980

tggtggcgcg tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa   2040

cctgggaggt ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac   2100

agagcaagac tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat   2160

attctggagt catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc   2220

agtgttggcc atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt   2280

caaagccatt ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt   2340

ttcaaccatg aagtctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta   2400

ctgtgtcttt ggtttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt   2460

acagtctatt tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt   2520

tttcagacct tttaactcct caattccaac actgatttcc ccttttgcat tctccctcct   2580

tcccttcctt gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga   2640

cctggaggag cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat   2700

gactaattct tgcatatttt gtaacttcca tgtgagggtt ttcagcattg atatttgtgc   2760

attttctaaa cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa   2820

aaaagaatag ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc   2880

tctgccataa atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa   2940

ggctctgttt atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac   3000

atatccgtat atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg   3060

agaggcattt cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa   3120

cttgagaact ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc   3180

tatttgcaat tcctgctcct aggggagggg agataagaaa ccctcactct ctacaggttt   3240

gggtacaagt ggcaacctgc ttccatggcc gtgtagaagc atggtgccct ggcttctctg   3300

aggaagctgg ggttcatgac aatggcagat gtaaagttat tcttgaagtc agattgaggc   3360

tgggagacag ccgtagtaga tgttctactt tgttctgctg ttctctagaa agaatatttg   3420

gttttcctgt ataggaatga gattaattcc tttccaggta ttttataatt ctgggaagca   3480

aaacccatgc ctccccctag ccatttttac tgttatccta tttagatggc catgaagagg   3540

atgctgtgaa attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa   3600

gtgatctttt gttcccatcc tcttctttta gcagtaaaat agctgaggga aaagggaggg   3660

aaaaggaagt tatgggaata cctgtggtgg ttgtgatccc taggtcttgg gagctcttgg   3720

aggtgtctgt atcagtggat ttcccatccc ctgtgggaaa ttagtaggct catttactgt   3780

tttaggtcta gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat   3840

ggtaattctt attctttcgt tcagttaagt ttttcccttc atctgggcac tgaagggata   3900

tgtgaaacaa tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc   3960

ttataggaaa gcttgagtaa aataaatatt gtctttttgt atgtca                  4006


<210>  4237
<211>  427
<212>  PRT
<213>  Homosapiens

<400>  4237

Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln 
            20                  25                  30          


Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 
        35                  40                  45              


Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu 
    50                  55                  60                  


Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro 
65                  70                  75                  80  


Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 
                85                  90                  95      


Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile 
            100                 105                 110         


Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala 
        115                 120                 125             


Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys 
    130                 135                 140                 


Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile 
                165                 170                 175     


Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val 
            180                 185                 190         


Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp 
        195                 200                 205             


Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 
    210                 215                 220                 


Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn 
225                 230                 235                 240 


Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg 
                245                 250                 255     


Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His 
            260                 265                 270         


Asn Val Phe Tyr Val Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu 
        275                 280                 285             


Arg Asn Val Glu Asn Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro 
    290                 295                 300                 


Asp Thr Leu Asn Thr Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys 
305                 310                 315                 320 


Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile 
                325                 330                 335     


Gly Lys Lys Arg Asn Ser Thr Leu Tyr Ile Thr Met Leu Leu Ile Val 
            340                 345                 350         


Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys 
        355                 360                 365             


Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile 
    370                 375                 380                 


Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys 
385                 390                 395                 400 


Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val 
                405                 410                 415     


Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 
            420                 425         


<210>  4238
<211>  2212
<212>  DNA
<213>  Homosapiens

<400>  4238
ggcgctgcct cgtctctgct acccctggtt gggcggccct gcgaagcagc tccttcgggc     60

agccccgggt cgcttagcgg ccaaggaggc ttcagttctt tgccgcctgc aaggcggaga    120

ccagaaggcg gaatccacag ctggcgacgc gggagcatct gctgtccacc agcggagcac    180

aggccatcaa agccgcatct gaacttgaat tctgtgcagc tgattgcaga gctggacccg    240

gatctgcgac cccctgtgga cagaggttga ccgtaccccg gagaggagct ttctcacgga    300

gggcactggt tgcagaggct ggaagtgaaa taaagacgcg ctcttgtttc agagttcgtc    360

ccctgctgag ataggaaggc agagccacct cctctcctct cccacctgca gattaagctt    420

ttctaaaaag cctaggcatc ttcttatatt cagataccct atcgtcgtca gtcatggcta    480

gcatcattgc acgtgtcggt aacagccggc ggctgaatgc acccttgccg ccttgggccc    540

attccatgct gaggtccctg gggagaagtc tcggtcctat aatggccagc atggcagaca    600

gaaacatgaa gttgttctcg gggagggtgg tgccagccca aggggaagaa acctttgaaa    660

actggctgac ccaagtcaat ggcgtcctgc cagattggaa tatgtctgag gaggaaaagc    720

tcaagcgctt gatgaaaacc cttaggggcc ctgcccgcga ggtcatgcgt gtgcttcagg    780

cgaccaaccc taacctaagt gtggcagatt tcttgcgagc catgaaattg gtgtttgggg    840

agtctgaaag cagtgtgact gcccatggta aattttttaa caccctacaa gctcaagggg    900

agaaagcctc cctttatgtg atccgtttag aggtgcagct ccagaacgct attcaggcag    960

gcattatagc tgagaaagat gcaaaccgga ctcgcttgca gcagctcctt ttaggcggtg   1020

agctgagtag ggacctccga ctcagactta aggattttct caggatgtat gcaaatgagc   1080

aggagcggct tcccaacttt ctggagttaa tcagaatggt aagggaggaa gaggattggg   1140

atgatgcttt tattaaacgg aagcgtccaa aaaggtctga gtcaatggtg gagagggcag   1200

tcagccctgt ggcatttcag ggctccccac cgatagtgat cggcagtgct gactgcaatg   1260

tgatagagat agatgatacc ctcgacgact ccgatgagga tgtgatcctg gtggagtctc   1320

aggaccctcc acttccatcc tggggtgccc ctcccctcag agacagggcc agacctcagg   1380

atgaagtgct ggtcattgat tccccccaca attccagggc tcagtttcct tccaccagtg   1440

gtggttctgg ctataagaat aacggtcctg gggagatgcg tagagccagg aagcgaaaac   1500

acacaatccg ctgttcgtat tgtggtgagg aaggccactc aaaagaaacc tgtgacaacg   1560

agagtgacaa ggcccaggtt tttgagaatt tgatcatcac tctccaggag ctgacccata   1620

ctgagatgga gaggtcaaga gtggcccctg gcgaatacaa tgacttctct gagccactgt   1680

aagggaccac ccccaggttt cagtgaaccc ttacctatat tcagcatcca gtagtgggaa   1740

aactggggtg ggggtggggg tgggacttct aactgcatga attaatccac aaagcggcta   1800

tcttttgggg tggagtagaa agggtcttgg ataccagcac attggaggga gatagcctga   1860

cctctgtcct tgctccttct ccctgcagcc tacgggtctg ttttctgtgt gtgcccattt   1920

ccttgacagc tttattcttt gtgaaagtgg tataatttat tgttaaatat ttgaacaata   1980

aaaaaggtac aaaaagtgaa gtacaaatta cccaaatctc tccaccctta tataatcatt   2040

gtcaaccctt tgatgagtga tatttcccta tacctatgta cccagataga tatatgcata   2100

gataaaagtg atgaaatata agtgctgttc tatctgtatt ttttcaccaa acaatatatg   2160

ttgtgagctt ctatgtcaat aaatatatat atcagcaaaa aaaaaaaaaa aa           2212


<210>  4239
<211>  402
<212>  PRT
<213>  Homosapiens

<400>  4239

Met Ala Ser Ile Ile Ala Arg Val Gly Asn Ser Arg Arg Leu Asn Ala 
1               5                   10                  15      


Pro Leu Pro Pro Trp Ala His Ser Met Leu Arg Ser Leu Gly Arg Ser 
            20                  25                  30          


Leu Gly Pro Ile Met Ala Ser Met Ala Asp Arg Asn Met Lys Leu Phe 
        35                  40                  45              


Ser Gly Arg Val Val Pro Ala Gln Gly Glu Glu Thr Phe Glu Asn Trp 
    50                  55                  60                  


Leu Thr Gln Val Asn Gly Val Leu Pro Asp Trp Asn Met Ser Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Lys Arg Leu Met Lys Thr Leu Arg Gly Pro Ala Arg Glu 
                85                  90                  95      


Val Met Arg Val Leu Gln Ala Thr Asn Pro Asn Leu Ser Val Ala Asp 
            100                 105                 110         


Phe Leu Arg Ala Met Lys Leu Val Phe Gly Glu Ser Glu Ser Ser Val 
        115                 120                 125             


Thr Ala His Gly Lys Phe Phe Asn Thr Leu Gln Ala Gln Gly Glu Lys 
    130                 135                 140                 


Ala Ser Leu Tyr Val Ile Arg Leu Glu Val Gln Leu Gln Asn Ala Ile 
145                 150                 155                 160 


Gln Ala Gly Ile Ile Ala Glu Lys Asp Ala Asn Arg Thr Arg Leu Gln 
                165                 170                 175     


Gln Leu Leu Leu Gly Gly Glu Leu Ser Arg Asp Leu Arg Leu Arg Leu 
            180                 185                 190         


Lys Asp Phe Leu Arg Met Tyr Ala Asn Glu Gln Glu Arg Leu Pro Asn 
        195                 200                 205             


Phe Leu Glu Leu Ile Arg Met Val Arg Glu Glu Glu Asp Trp Asp Asp 
    210                 215                 220                 


Ala Phe Ile Lys Arg Lys Arg Pro Lys Arg Ser Glu Ser Met Val Glu 
225                 230                 235                 240 


Arg Ala Val Ser Pro Val Ala Phe Gln Gly Ser Pro Pro Ile Val Ile 
                245                 250                 255     


Gly Ser Ala Asp Cys Asn Val Ile Glu Ile Asp Asp Thr Leu Asp Asp 
            260                 265                 270         


Ser Asp Glu Asp Val Ile Leu Val Glu Ser Gln Asp Pro Pro Leu Pro 
        275                 280                 285             


Ser Trp Gly Ala Pro Pro Leu Arg Asp Arg Ala Arg Pro Gln Asp Glu 
    290                 295                 300                 


Val Leu Val Ile Asp Ser Pro His Asn Ser Arg Ala Gln Phe Pro Ser 
305                 310                 315                 320 


Thr Ser Gly Gly Ser Gly Tyr Lys Asn Asn Gly Pro Gly Glu Met Arg 
                325                 330                 335     


Arg Ala Arg Lys Arg Lys His Thr Ile Arg Cys Ser Tyr Cys Gly Glu 
            340                 345                 350         


Glu Gly His Ser Lys Glu Thr Cys Asp Asn Glu Ser Asp Lys Ala Gln 
        355                 360                 365             


Val Phe Glu Asn Leu Ile Ile Thr Leu Gln Glu Leu Thr His Thr Glu 
    370                 375                 380                 


Met Glu Arg Ser Arg Val Ala Pro Gly Glu Tyr Asn Asp Phe Ser Glu 
385                 390                 395                 400 


Pro Leu 
        


<210>  4240
<211>  2277
<212>  DNA
<213>  Homosapiens

<400>  4240
gtaggggacc gcctggggat ccccggacgg ctgcgaggaa tgagcggttg gctcgggctg     60

gtttcctccc tccaccgcct gcttgtttcg ccatgcccgg gccggacggt ggggctgcag    120

cggcgaaagc gactgaagtc cgggagcagt cgcatgagct tcccggtcac caggaggccc    180

cgggaacaga cacctcaccc tgacattgtg gcaggaactt ctggattgct ttccaaagtg    240

gctgcactgt tttctatccc cactgggcag gaaaacatct aagaaaggag gctcccccct    300

tcccttgcag ggttaccagc aattaaaaag aagtactaga gaggcaaata tcggcagtat    360

acatctaagc gctggtcgga aaagaaggaa ctcagcccaa gaacttgccc aatctgatac    420

tggaggtgcc actcaagaac cactccctcc aagatgtttt cctggatttc ctcagcctaa    480

agtaatccct ctttttcctg gctataccat ctggaacaga tgacttccaa ggacaccgta    540

gcaaagaaaa agagaactgg aagcccatgt gccttaatcg cttcatccta gaggaggagg    600

ataaccagtg gagccttttc tggatttctc actagaagta aagaccaaat ttccagaagg    660

aacctgagag ataaaaagtg gttggctgct cctgacctga ctcatagtgt ttaactgaac    720

cataccacta gtgtatacta gtgtgtgtgt atgtacatgc atacacacat gcacacacac    780

attcacacac aatcctatgg tatttggtga ctttggatgc ccagctcttg caacaatttc    840

ctgctgtcat tcttttccct ttgaatctca ggggtgagca aactaaagaa atactatcat    900

cttactgctt ttagtatatt ccatagaaaa ggagtggctg gagtcagtgt agatcaaccc    960

aagcagtaca aatctgccag aattgcagct cagcttcctt acctccagca tgtgtacctt   1020

tctgaagggt aggcccttaa gccagacata agtaagttat ccactctgtg cataactgtc   1080

tgacttggct tagaagcatg aaaggggcag aaatgtaaga tgggtaaaga agggcttcat   1140

ctgaaatagg gccatgatga ttagctctct ctttccttcc tttggcttca ttgctgtatt   1200

ccatgtgggt cttgatatct tgaaactgga tgagataccc aaatagtcag tccctgaata   1260

taaatcattt ccttgtacag aatcactgcc aaactcagta tggttaaaag atttttaaca   1320

cccagctgca gcattcactc tggttagaat tggccattta aatttatttc acatatgtaa   1380

gtatcatatc ctttataatg cattcttaat tgttgctcag ttcttccaga ttgaattcct   1440

ttaaaaaatt ccttatgtaa tcttttaatt ctagttggaa aacatcactt gacagttgct   1500

gtttatacag gcatgcctcg ttttattgtg cctggcttta ttgtactttg cagatactgt   1560

gtttttcaca aatggaaggt ttgtggcaac cctgcgttaa gcaagtctgt tggcaccatt   1620

ttctcgacag catgtgctaa ctttgtctct gtctcacatt ttggtaattc tctcaatgtt   1680

tcaaactttt tcattatgat tacatctgtt atgtggagct gtgatcagtg atctttgatg   1740

ttaacattgt aattgttttg gggtgccaca actgtgccca gataagacag tgaacttaat   1800

tggtaaatgt tttatgtgtt cagactgttc cactgactag cccttcttca aactctctca   1860

ctctccttgg gcctccctat tccctgaaat acaacaatat tgatattaag ccaattaata   1920

accctacaat gatttccaag tgtttaagtg aaaggaaaga catgtatgtt tcaccttaaa   1980

tcaaaagcta gaaatggcca ggcgtggagg ctcacgcctg taatcccagc actttgggag   2040

gccaaggcgg gcggatcaca aggtcaggag atcgagacca tcctggctaa cacggtgaaa   2100

ccctgtctct actaaaaaat acaaaaaatt agccgggcgt agtggcaggc gcctgtagtc   2160

ccagctacat gggaggctga ggcaggagaa tggcgtgaac ctgggaggcg gagcttgcag   2220

tgagccgaga tcgcgccact gcattccagc ctgggtgaca gagcgagact ccatctc      2277


<210>  4241
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  4241

Met Ser Gly Trp Leu Gly Leu Val Ser Ser Leu His Arg Leu Leu Val 
1               5                   10                  15      


Ser Pro Cys Pro Gly Arg Thr Val Gly Leu Gln Arg Arg Lys Arg Leu 
            20                  25                  30          


Lys Ser Gly Ser Ser Arg Met Ser Phe Pro Val Thr Arg Arg Pro Arg 
        35                  40                  45              


Glu Gln Thr Pro His Pro Asp Ile Val Ala Gly Thr Ser Gly Leu Leu 
    50                  55                  60                  


Ser Lys Val Ala Ala Leu Phe Ser Ile Pro Thr Gly Gln Glu Asn Ile 
65                  70                  75                  80  


<210>  4242
<211>  2625
<212>  DNA
<213>  Homosapiens

<400>  4242
acgcctcgtc tcctcccgtg tccctcttcc catggagtca gtacggatcg aacagatgct     60

gagcttgccc gctgaggtca gcagcgacaa cttggagtcg gcggagcgag gggcatcagc    120

ggcccaagta gacatgggcc cccacccaaa ggtggctgca gagggccccg cacctctacc    180

gacgcgggag ccagagcaag agcagtctcc ggggacctca acgccggaga gcaaagtcct    240

gctcacgcag gcagacgcct tggcgtcccg ggggcgaatc cgtgaagccc tcgaggtgta    300

tagacagctc tccgagcggc agcagctggt ggctgagcag ctggagcagc tggtgcgctg    360

cctggcggag aaagtcccgc aaggcgaggc gctggcgccg gcgcccccgg acgagggtag    420

cactgcaagc ggcaccgtgg cggcggaaga gacgggggcc gccgcggctg cggcggccac    480

cgaggtgtgg gacggcttta agtgccggaa atgtcatggg tttctatcag accccgtgtc    540

cttgtcgtgt ggccacacct tttgtaaact gtgcctggaa cgtgggcggg ccgccgaccg    600

gcgctgtgcg ctgtgcgggg tcaagctctc cgccttgatg gtggccactg ggcgggcgcg    660

tggagcccgg cgggctgggc agcagccgcc gccgccgctg cgagtcaacg tggtgctcag    720

cggcctcctc ggcaagttgt ttccaggccc agcgcgagcg tcgcaactcc ggcacgaggg    780

caaccgactg taccgcgagc gccaggtgga ggcggcactg ctcaagtaca acgaggcagt    840

taagttggct ccaaatgacc acttgcttta tagcaatcgg tctcagattt atttcacctt    900

ggagtctcat gagaatgcac tgcatgatgc agaaatagca tgtaagctcc gcccgatggg    960

ttttaaggca catttcagaa aagcccaagc cttagccacc ctaggcaagg tggaggaggc   1020

actaagggag tttctctact gtgtatccct tgatggaaag aacaagagag caagatgtga   1080

agcccaaaga gacaatctgg agctcccaca ttgttctagt caggaggaag cagcagccag   1140

gggagatggc agcagtctga tggacccagc taaagtgaag ggggatggtc agcagcacca   1200

catgaaagac caggaagaag aggaggagaa gtgggatgct acctctccaa aagctgcttc   1260

cagcaagact ggaaaatgcc aggaaaagaa aaggaaacat tgccagattg aatcccaaga   1320

agaaacgggg atgcctaata aagcctccaa gcaagatcct cccactgatc agggggacaa   1380

acctgctctc agtttaccac ttgcatcttt cgacgcatct gaccttgaat gcgctctatg   1440

tatgagatta ttctatgagc cagtcacaac accttgcggg catacttttt gcttaaaatg   1500

cctagaaaga tgcctagatc acaacgcaaa gtgtccattg tgcaaagacg gtctttcaca   1560

gtgcttggca tcaagaaaat acagcaaaaa tgtaataatg gaggagctca tagctaaatt   1620

ccttccagaa gaactgaagg aacgaaggaa gctttatgaa gaggaaatgg aagaactttc   1680

taaccttaat aagaatgtgc ctattttcgt gtgtactatg gcctatccca ccgttccttg   1740

tcccctgcac atctttgagc cttgttaccg cctgatgatt cgtagatgca ttgagacagg   1800

cacgagacag tttggcatgt gccttggaga tcctgtcaaa gggtttgcag aatatggctg   1860

catcctagag atcagaaatg ttcaattctt tgctgatggc cgctcagtgg ttgacagcat   1920

aggcaagagg cgcttcaggg tgctccatca gagccagcgg gatggctaca acacagccga   1980

cattgaatac attgaagacc aaaaggttca gggagaggat tgtgctgagc tcatgggatt   2040

acataactgt gtctatcagc aagcatcatt gtggtttcat tcgctcaaat tatccctaaa   2100

gaatcggata ctcaatcact ttggtcccat gccggagaaa gacgccgatc ctcagatgaa   2160

cccgaatggc ccagcctggt gctggtggat gttagcagtt cttcccttgg aaagccgagc   2220

tcagctcccc ttcctagcaa tgaggtcctt aaaggacaga ctgaatggta ttcgacgagt   2280

cctggccttc atatcccgaa accaaaacta gtgagtggat tgccgaagag gagctcccac   2340

cttccccact gccgtcgggg ggagtcttct tgtaaatata tctaattgca ataatatctt   2400

aacagaaggg ggtgtcaaac agaggcatca gcctgctgtt gatcacagag agaaattgag   2460

tagaaagacc aaaagaatgt gacctatttg aaactttctg tcttaagatg cttcttgaca   2520

tgctgcataa ctacataaac agcagaggtg tttaagagcc cagaaaaaca taatttgatt   2580

ttaacattaa aatttccaaa agtttaaaaa aaaaaaaaaa aaaaa                   2625


<210>  4243
<211>  759
<212>  PRT
<213>  Homosapiens

<400>  4243

Met Glu Ser Val Arg Ile Glu Gln Met Leu Ser Leu Pro Ala Glu Val 
1               5                   10                  15      


Ser Ser Asp Asn Leu Glu Ser Ala Glu Arg Gly Ala Ser Ala Ala Gln 
            20                  25                  30          


Val Asp Met Gly Pro His Pro Lys Val Ala Ala Glu Gly Pro Ala Pro 
        35                  40                  45              


Leu Pro Thr Arg Glu Pro Glu Gln Glu Gln Ser Pro Gly Thr Ser Thr 
    50                  55                  60                  


Pro Glu Ser Lys Val Leu Leu Thr Gln Ala Asp Ala Leu Ala Ser Arg 
65                  70                  75                  80  


Gly Arg Ile Arg Glu Ala Leu Glu Val Tyr Arg Gln Leu Ser Glu Arg 
                85                  90                  95      


Gln Gln Leu Val Ala Glu Gln Leu Glu Gln Leu Val Arg Cys Leu Ala 
            100                 105                 110         


Glu Lys Val Pro Gln Gly Glu Ala Leu Ala Pro Ala Pro Pro Asp Glu 
        115                 120                 125             


Gly Ser Thr Ala Ser Gly Thr Val Ala Ala Glu Glu Thr Gly Ala Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Thr Glu Val Trp Asp Gly Phe Lys Cys Arg Lys 
145                 150                 155                 160 


Cys His Gly Phe Leu Ser Asp Pro Val Ser Leu Ser Cys Gly His Thr 
                165                 170                 175     


Phe Cys Lys Leu Cys Leu Glu Arg Gly Arg Ala Ala Asp Arg Arg Cys 
            180                 185                 190         


Ala Leu Cys Gly Val Lys Leu Ser Ala Leu Met Val Ala Thr Gly Arg 
        195                 200                 205             


Ala Arg Gly Ala Arg Arg Ala Gly Gln Gln Pro Pro Pro Pro Leu Arg 
    210                 215                 220                 


Val Asn Val Val Leu Ser Gly Leu Leu Gly Lys Leu Phe Pro Gly Pro 
225                 230                 235                 240 


Ala Arg Ala Ser Gln Leu Arg His Glu Gly Asn Arg Leu Tyr Arg Glu 
                245                 250                 255     


Arg Gln Val Glu Ala Ala Leu Leu Lys Tyr Asn Glu Ala Val Lys Leu 
            260                 265                 270         


Ala Pro Asn Asp His Leu Leu Tyr Ser Asn Arg Ser Gln Ile Tyr Phe 
        275                 280                 285             


Thr Leu Glu Ser His Glu Asn Ala Leu His Asp Ala Glu Ile Ala Cys 
    290                 295                 300                 


Lys Leu Arg Pro Met Gly Phe Lys Ala His Phe Arg Lys Ala Gln Ala 
305                 310                 315                 320 


Leu Ala Thr Leu Gly Lys Val Glu Glu Ala Leu Arg Glu Phe Leu Tyr 
                325                 330                 335     


Cys Val Ser Leu Asp Gly Lys Asn Lys Arg Ala Arg Cys Glu Ala Gln 
            340                 345                 350         


Arg Asp Asn Leu Glu Leu Pro His Cys Ser Ser Gln Glu Glu Ala Ala 
        355                 360                 365             


Ala Arg Gly Asp Gly Ser Ser Leu Met Asp Pro Ala Lys Val Lys Gly 
    370                 375                 380                 


Asp Gly Gln Gln His His Met Lys Asp Gln Glu Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Trp Asp Ala Thr Ser Pro Lys Ala Ala Ser Ser Lys Thr Gly Lys Cys 
                405                 410                 415     


Gln Glu Lys Lys Arg Lys His Cys Gln Ile Glu Ser Gln Glu Glu Thr 
            420                 425                 430         


Gly Met Pro Asn Lys Ala Ser Lys Gln Asp Pro Pro Thr Asp Gln Gly 
        435                 440                 445             


Asp Lys Pro Ala Leu Ser Leu Pro Leu Ala Ser Phe Asp Ala Ser Asp 
    450                 455                 460                 


Leu Glu Cys Ala Leu Cys Met Arg Leu Phe Tyr Glu Pro Val Thr Thr 
465                 470                 475                 480 


Pro Cys Gly His Thr Phe Cys Leu Lys Cys Leu Glu Arg Cys Leu Asp 
                485                 490                 495     


His Asn Ala Lys Cys Pro Leu Cys Lys Asp Gly Leu Ser Gln Cys Leu 
            500                 505                 510         


Ala Ser Arg Lys Tyr Ser Lys Asn Val Ile Met Glu Glu Leu Ile Ala 
        515                 520                 525             


Lys Phe Leu Pro Glu Glu Leu Lys Glu Arg Arg Lys Leu Tyr Glu Glu 
    530                 535                 540                 


Glu Met Glu Glu Leu Ser Asn Leu Asn Lys Asn Val Pro Ile Phe Val 
545                 550                 555                 560 


Cys Thr Met Ala Tyr Pro Thr Val Pro Cys Pro Leu His Ile Phe Glu 
                565                 570                 575     


Pro Cys Tyr Arg Leu Met Ile Arg Arg Cys Ile Glu Thr Gly Thr Arg 
            580                 585                 590         


Gln Phe Gly Met Cys Leu Gly Asp Pro Val Lys Gly Phe Ala Glu Tyr 
        595                 600                 605             


Gly Cys Ile Leu Glu Ile Arg Asn Val Gln Phe Phe Ala Asp Gly Arg 
    610                 615                 620                 


Ser Val Val Asp Ser Ile Gly Lys Arg Arg Phe Arg Val Leu His Gln 
625                 630                 635                 640 


Ser Gln Arg Asp Gly Tyr Asn Thr Ala Asp Ile Glu Tyr Ile Glu Asp 
                645                 650                 655     


Gln Lys Val Gln Gly Glu Asp Cys Ala Glu Leu Met Gly Leu His Asn 
            660                 665                 670         


Cys Val Tyr Gln Gln Ala Ser Leu Trp Phe His Ser Leu Lys Leu Ser 
        675                 680                 685             


Leu Lys Asn Arg Ile Leu Asn His Phe Gly Pro Met Pro Glu Lys Asp 
    690                 695                 700                 


Ala Asp Pro Gln Met Asn Pro Asn Gly Pro Ala Trp Cys Trp Trp Met 
705                 710                 715                 720 


Leu Ala Val Leu Pro Leu Glu Ser Arg Ala Gln Leu Pro Phe Leu Ala 
                725                 730                 735     


Met Arg Ser Leu Lys Asp Arg Leu Asn Gly Ile Arg Arg Val Leu Ala 
            740                 745                 750         


Phe Ile Ser Arg Asn Gln Asn 
        755                 


<210>  4244
<211>  2502
<212>  DNA
<213>  Homosapiens

<400>  4244
acgcctcgtc tcctcccgtg tccctcttcc catggagtca gtacggatcg aacagatgct     60

gagcttgccc gctgaggtca gcagcgacaa cttggagtcg gcggagcgag gggcatcagc    120

ggcccaagta gacatgggcc cccacccaaa ggtggctgca gagggccccg cacctctacc    180

gacgcgggag ccagagcaag agcagtctcc ggggacctca acgccggaga gcaaagtcct    240

gctcacgcag gcagacgcct tggcgtcccg ggggcgaatc cgtgaagccc tcgaggtgta    300

tagacagctc tccgagcggc agcagctggt ggctgagcag ctggagcagc tggtgcgctg    360

cctggcggag aaagtcccgc aaggcgaggc gctggcgccg gcgcccccgg acgagggtag    420

cactgcaagc ggcaccgtgg cggcggaaga gacgggggcc gccgcggctg cggcggccac    480

cgaggtgtgg gacggcttta agtgccggaa atgtcatggg tttctatcag accccgtgtc    540

cttgtcgtgt ggccacacct tttgtaaact gtgcctggaa cgtgggcggg ccgccgaccg    600

gcgctgtgcg ctgtgcgggg tcaagctctc cgccttgatg gtggccactg ggcgggcgcg    660

tggagcccgg cgggctgggc agcagccgcc gccgccgctg cgagtcaacg tggtgctcag    720

cggcctcctc ggcaagttgt ttccaggccc agcgcgagcg tcgcaactcc ggcacgaggg    780

caaccgactg taccgcgagc gccaggtgga ggcggcactg ctcaagtaca acgaggcagt    840

taagttggct ccaaatgacc acttgcttta tagcaatcgg tctcagattt atttcacctt    900

ggagtctcat gagaatgcac tgcatgatgc agaaatagca tgtaagctcc gcccgatggg    960

ttttaaggac aatctggagc tcccacattg ttctagtcag gaggaagcag cagccagggg   1020

agatggcagc agtctgatgg acccagctaa agtgaagggg gatggtcagc agcaccacat   1080

gaaagaccag gaagaagagg aggagaagtg ggatgctacc tctccaaaag ctgcttccag   1140

caagactgga aaatgccagg aaaagaaaag gaaacattgc cagattgaat cccaagaaga   1200

aacggggatg cctaataaag cctccaagca agatcctccc actgatcagg gggacaaacc   1260

tgctctcagt ttaccacttg catctttcga cgcatctgac cttgaatgcg ctctatgtat   1320

gagattattc tatgagccag tcacaacacc ttgcgggcat actttttgct taaaatgcct   1380

agaaagatgc ctagatcaca acgcaaagtg tccattgtgc aaagacggtc tttcacagtg   1440

cttggcatca agaaaataca gcaaaaatgt aataatggag gagctcatag ctaaattcct   1500

tccagaagaa ctgaaggaac gaaggaagct ttatgaagag gaaatggaag aactttctaa   1560

ccttaataag aatgtgccta ttttcgtgtg tactatggcc tatcccaccg ttccttgtcc   1620

cctgcacatc tttgagcctt gttaccgcct gatgattcgt agatgcattg agacaggcac   1680

gagacagttt ggcatgtgcc ttggagatcc tgtcaaaggg tttgcagaat atggctgcat   1740

cctagagatc agaaatgttc aattctttgc tgatggccgc tcagtggttg acagcatagg   1800

caagaggcgc ttcagggtgc tccatcagag ccagcgggat ggctacaaca cagccgacat   1860

tgaatacatt gaagaccaaa aggttcaggg agaggattgt gctgagctca tgggattaca   1920

taactgtgtc tatcagcaag catcattgtg gtttcattcg ctcaaattat ccctaaagaa   1980

tcggatactc aatcactttg gtcccatgcc ggagaaagac gccgatcctc agatgaaccc   2040

gaatggccca gcctggtgct ggtggatgtt agcagttctt cccttggaaa gccgagctca   2100

gctccccttc ctagcaatga ggtccttaaa ggacagactg aatggtattc gacgagtcct   2160

ggccttcata tcccgaaacc aaaactagtg agtggattgc cgaagaggag ctcccacctt   2220

ccccactgcc gtcgggggga gtcttcttgt aaatatatct aattgcaata atatcttaac   2280

agaagggggt gtcaaacaga ggcatcagcc tgctgttgat cacagagaga aattgagtag   2340

aaagaccaaa agaatgtgac ctatttgaaa ctttctgtct taagatgctt cttgacatgc   2400

tgcataacta cataaacagc agaggtgttt aagagcccag aaaaacataa tttgatttta   2460

acattaaaat ttccaaaagt ttaaaaaaaa aaaaaaaaaa aa                      2502


<210>  4245
<211>  718
<212>  PRT
<213>  Homosapiens

<400>  4245

Met Glu Ser Val Arg Ile Glu Gln Met Leu Ser Leu Pro Ala Glu Val 
1               5                   10                  15      


Ser Ser Asp Asn Leu Glu Ser Ala Glu Arg Gly Ala Ser Ala Ala Gln 
            20                  25                  30          


Val Asp Met Gly Pro His Pro Lys Val Ala Ala Glu Gly Pro Ala Pro 
        35                  40                  45              


Leu Pro Thr Arg Glu Pro Glu Gln Glu Gln Ser Pro Gly Thr Ser Thr 
    50                  55                  60                  


Pro Glu Ser Lys Val Leu Leu Thr Gln Ala Asp Ala Leu Ala Ser Arg 
65                  70                  75                  80  


Gly Arg Ile Arg Glu Ala Leu Glu Val Tyr Arg Gln Leu Ser Glu Arg 
                85                  90                  95      


Gln Gln Leu Val Ala Glu Gln Leu Glu Gln Leu Val Arg Cys Leu Ala 
            100                 105                 110         


Glu Lys Val Pro Gln Gly Glu Ala Leu Ala Pro Ala Pro Pro Asp Glu 
        115                 120                 125             


Gly Ser Thr Ala Ser Gly Thr Val Ala Ala Glu Glu Thr Gly Ala Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Thr Glu Val Trp Asp Gly Phe Lys Cys Arg Lys 
145                 150                 155                 160 


Cys His Gly Phe Leu Ser Asp Pro Val Ser Leu Ser Cys Gly His Thr 
                165                 170                 175     


Phe Cys Lys Leu Cys Leu Glu Arg Gly Arg Ala Ala Asp Arg Arg Cys 
            180                 185                 190         


Ala Leu Cys Gly Val Lys Leu Ser Ala Leu Met Val Ala Thr Gly Arg 
        195                 200                 205             


Ala Arg Gly Ala Arg Arg Ala Gly Gln Gln Pro Pro Pro Pro Leu Arg 
    210                 215                 220                 


Val Asn Val Val Leu Ser Gly Leu Leu Gly Lys Leu Phe Pro Gly Pro 
225                 230                 235                 240 


Ala Arg Ala Ser Gln Leu Arg His Glu Gly Asn Arg Leu Tyr Arg Glu 
                245                 250                 255     


Arg Gln Val Glu Ala Ala Leu Leu Lys Tyr Asn Glu Ala Val Lys Leu 
            260                 265                 270         


Ala Pro Asn Asp His Leu Leu Tyr Ser Asn Arg Ser Gln Ile Tyr Phe 
        275                 280                 285             


Thr Leu Glu Ser His Glu Asn Ala Leu His Asp Ala Glu Ile Ala Cys 
    290                 295                 300                 


Lys Leu Arg Pro Met Gly Phe Lys Asp Asn Leu Glu Leu Pro His Cys 
305                 310                 315                 320 


Ser Ser Gln Glu Glu Ala Ala Ala Arg Gly Asp Gly Ser Ser Leu Met 
                325                 330                 335     


Asp Pro Ala Lys Val Lys Gly Asp Gly Gln Gln His His Met Lys Asp 
            340                 345                 350         


Gln Glu Glu Glu Glu Glu Lys Trp Asp Ala Thr Ser Pro Lys Ala Ala 
        355                 360                 365             


Ser Ser Lys Thr Gly Lys Cys Gln Glu Lys Lys Arg Lys His Cys Gln 
    370                 375                 380                 


Ile Glu Ser Gln Glu Glu Thr Gly Met Pro Asn Lys Ala Ser Lys Gln 
385                 390                 395                 400 


Asp Pro Pro Thr Asp Gln Gly Asp Lys Pro Ala Leu Ser Leu Pro Leu 
                405                 410                 415     


Ala Ser Phe Asp Ala Ser Asp Leu Glu Cys Ala Leu Cys Met Arg Leu 
            420                 425                 430         


Phe Tyr Glu Pro Val Thr Thr Pro Cys Gly His Thr Phe Cys Leu Lys 
        435                 440                 445             


Cys Leu Glu Arg Cys Leu Asp His Asn Ala Lys Cys Pro Leu Cys Lys 
    450                 455                 460                 


Asp Gly Leu Ser Gln Cys Leu Ala Ser Arg Lys Tyr Ser Lys Asn Val 
465                 470                 475                 480 


Ile Met Glu Glu Leu Ile Ala Lys Phe Leu Pro Glu Glu Leu Lys Glu 
                485                 490                 495     


Arg Arg Lys Leu Tyr Glu Glu Glu Met Glu Glu Leu Ser Asn Leu Asn 
            500                 505                 510         


Lys Asn Val Pro Ile Phe Val Cys Thr Met Ala Tyr Pro Thr Val Pro 
        515                 520                 525             


Cys Pro Leu His Ile Phe Glu Pro Cys Tyr Arg Leu Met Ile Arg Arg 
    530                 535                 540                 


Cys Ile Glu Thr Gly Thr Arg Gln Phe Gly Met Cys Leu Gly Asp Pro 
545                 550                 555                 560 


Val Lys Gly Phe Ala Glu Tyr Gly Cys Ile Leu Glu Ile Arg Asn Val 
                565                 570                 575     


Gln Phe Phe Ala Asp Gly Arg Ser Val Val Asp Ser Ile Gly Lys Arg 
            580                 585                 590         


Arg Phe Arg Val Leu His Gln Ser Gln Arg Asp Gly Tyr Asn Thr Ala 
        595                 600                 605             


Asp Ile Glu Tyr Ile Glu Asp Gln Lys Val Gln Gly Glu Asp Cys Ala 
    610                 615                 620                 


Glu Leu Met Gly Leu His Asn Cys Val Tyr Gln Gln Ala Ser Leu Trp 
625                 630                 635                 640 


Phe His Ser Leu Lys Leu Ser Leu Lys Asn Arg Ile Leu Asn His Phe 
                645                 650                 655     


Gly Pro Met Pro Glu Lys Asp Ala Asp Pro Gln Met Asn Pro Asn Gly 
            660                 665                 670         


Pro Ala Trp Cys Trp Trp Met Leu Ala Val Leu Pro Leu Glu Ser Arg 
        675                 680                 685             


Ala Gln Leu Pro Phe Leu Ala Met Arg Ser Leu Lys Asp Arg Leu Asn 
    690                 695                 700                 


Gly Ile Arg Arg Val Leu Ala Phe Ile Ser Arg Asn Gln Asn 
705                 710                 715             


<210>  4246
<211>  7398
<212>  DNA
<213>  Homosapiens

<400>  4246
atggctgaat cactaagtga aatttctgac agtctggatg ttctggaggc cggtgatgag     60

ggaaagaaga aatgcaaatt taaagccctt aagagctttt ttgttaagaa gaaggaaaaa    120

gaagccgaag atacccagga agaagaaatg ctagaactga gcttgtccag cagcaacatt    180

aacatctctt ctctgcagcc cgttcgggaa aatcaaccaa ctaaggccag ggccaagagc    240

agcatgggga gcaaagccct atcccatgat agcatcttca tgttgggtcc tgagcctgaa    300

agatcagcaa gtaaaatgtt tccttctatg gatccccaga gaggcagacc tcagcagaga    360

tcccatattt ccagaactct gcctaaacct aggagtaagg ttcctggagt tgtgtctgga    420

gccatgtcag gagctgtgct tcaaaatgtg cctacaagtg cagtctgggt tgctggcccc    480

aagatcactg agaacccacc atcgcgccga cgccgactca gcatcatccc acctgttatc    540

caacctgaaa taatttctaa gaacttggta gaaatctctc tcgatgatga gtcacctaag    600

aatccacaaa agaaggcttt accacataag agtttgacag cgactcagag cttctctgag    660

ttatcatctg gacctgattg ctcacagtcc ttgactgcat ttgccacact tgcctctacc    720

agtagcaccc agctgcccat tggtttcagc accccagcca ccacccaggg ctgtttggat    780

tcttcagctg ctcgccacaa aatgacttta aatccccgca aacaaaagaa gaaccttcaa    840

gtgattattc gtggccttcc agtgtggttc agtcatttcc agggtatttt agagggatcc    900

ctgcagtgtg tcactcagac attagaaact ccaaacctgg atgaaccact tccagtggaa    960

ccaaaggagg aggagccaaa ccttccattg gtttctgaag aagaaaagag cataaccaaa   1020

ccaaaagaaa tcaacgaaaa gaagctggga atggacagtg cagattcctc aagccagaaa   1080

cagaacaaca aaactgagat gtatgataag aagacaacag accaggctcc aaacactgat   1140

gcttctcgga gtcagggcta tccaatgtca gcagcatatg gaagaagatg gagaagaaaa   1200

ggagcaagtg tttcaggatt gagtgggtgt gaattcaaag gaagaagcct taaacaatcc   1260

agtgaagggt atggcctggg cgatagagct gggtcttcac ctaccaataa gactgccagg   1320

aatgtccctt tctcgcactt gtccttagag aaggacaaca tggagcagcc tacaacttca   1380

caaccagaaa ccactacccc tcaggggttg ctttcagata aagatgacat gggaaggaga   1440

aatgctggca tagatttcgg atccagaaaa gcatcagcag cacagcccat acctgaaaac   1500

atggacaatt ccatggttag tgatccacaa ccataccatg aagatgcagc ttctggagct   1560

gagaagacag aagccagagc ttctctctca ctgatggtgg aaagcctttc tacaacccaa   1620

gaggaggcca ttctctcagt agcagcagag gctcaggtgt ttatgaatcc ttctcatatc   1680

cagttagaag atcaagaagc tttcagcttt gatttacaaa aggcccaatc caaaatggag   1740

tcagcccagg atgttcaaac tatctgcaaa gaaaagcctt ctggaaatgt tcaccagacc   1800

tttacagcaa gtgttttggg tatgacaagt actacagcca aaggagatgt ttatgccaag   1860

actctgcctc ccagaagcct ttttcagtcc tcaaggaagc ctgatgctga agaagtctcc   1920

tcagattcag agaatattcc tgaggagggg gatggttctg aagaactggc tcatggtcac   1980

tcttcccagt ccttggggaa gtttgaagat gaacaagaag tcttctcaga atcaaaaagt   2040

tttgttgagg acttgagcag ctctgaggag gagctggacc tcagatgcct ctcccaggct   2100

ttagaggagc ctgaagatgc agaagtcttc acagaatcaa gcagttatgt tgaaaagtac   2160

aacacttctg atgattgcag cagctcagag gaagacctgc ctctcagaca ccctgctcag   2220

gccttgggaa agcccaaaaa ccaacaagaa gtctcctctg cttcaaataa tactcctgaa   2280

gagcagaatg attttatgca gcagctgcct tccagatgcc cttctcagcc cattatgaat   2340

cctactgttc agcaacaagt ccccaccagt tcagtgggca cttctataaa acagagcgat   2400

tccgtggagc caatccctcc aagacaccct ttccagccat gggtgaaccc taaagtggag   2460

caagaagttt cctcatctcc aaagagcatg gctgttgaag agagcatttc tatgaagcct   2520

ctgcctccta aacttctttg ccagcccttg atgaatccta aagttcaaca aaacatgttc   2580

tcaggttcag aggacattgc tgttgagaga gtcatttctg tggagccact actccccaga   2640

tattctcctc agtccttgac agatcctcaa atccggcaaa tctcagaaag cacagctgtt   2700

gaggaaggca cttatgtgga accgctgcct cccagatgcc tttcccagcc ctcggagagg   2760

cctaagttcc tggactcaat gagtacttct gcagaatgga gcagtcctgt ggcaccaaca   2820

ccttccaaat acacttcccc gccatgggtg acccctaaat ttgaggaact gtatcaactc   2880

tctgcacatc cagaaagcac tactgttgaa gaggacattt ctaaggagca gctgcttccc   2940

agacatcttt cccagttgac tgtgggaaat aaagtccagc aactgtcctc aaatttcgag   3000

cgggctgcta ttgaggcaga catttctggg agtccattgc ctccccaata tgctacccag   3060

ttcttaaaga ggtctaaagt tcaggaaatg acctcacgac tagagaaaat ggctgttgaa   3120

ggcacttcta acaaatcacc gattcccagg cgtccgaccc agtcattcgt gaaatttatg   3180

gcacagcaaa tcttttcaga gagctctgct cttaagaggg gcagtgatgt ggcacctctg   3240

cctcccaatc ttccttccaa atctttatca aagcctgaag tcaagcacca agttttctca   3300

gattcaggga gtgctaatcc taagggaggc atttcttcaa agatgctacc tatgaagcac   3360

cctttacagt ccttggggag gcctgaagac ccacagaaag ttttctctta ttcagagaga   3420

gctcctggga agtgcagcag ttttaaagag cagctgtctc ccaggcagct ttcccaggcc   3480

ttgaggaaac ctgagtatga gcaaaaagtc tcccctgttt ctgccagttc tcctaaagag   3540

tggaggaatt ctaaaaagca gctgcctccc aaacattctt cccaagcctc agataggtct   3600

aaattccagc cacagatgtc atcaaagggc ccagtgaatg tacctgtaaa gcagagcagc   3660

ggtgagaagc acctgccttc aagtagtcct ttccagcaac aggttcattc aagttctgtg   3720

aatgctgctg ctaggcgatc tgtttttgag agcaattctg acaattggtt cctaggaaga   3780

gatgaagctt ttgcaatcaa aaccaagaaa ttcagccaag gttccaaaaa ccccataaag   3840

agcattccag cccctgctac caaacctggg aagttcacca ttgctcctgt caggcaaaca   3900

tccacttctg ggggcattta ctctaagaaa gaagatcttg agagtggtga tggtaataat   3960

aaccagcatg caaacctatc caatcaggat gatgttgaaa agctttttgg agttcgactg   4020

aaaagagccc ctccctcgca gaagtataag agtgagaaac aagataactt cacccagctt   4080

gcttcagtgc cctcgggccc aatttcatcc tctgtaggca ggggacataa aatcagaagc   4140

acttcccagg ggctcctgga tgctgcaggg aacctcacca aaatatctta cgttgcagat   4200

aagcaacaga gcaggcccaa atctgaaagc atggccaaga agcaacctgc ttgcaagacc   4260

ccaggaaagc ctgctggtca acagtcagat tatgctgtct cagagccggt ttggataact   4320

atggcaaagc agaagcagaa gagtttcaag gcccacattt ctgtgaaaga gctgaaaact   4380

aagagcaatg ctggagccga tgctgagact aaggagccta aatatgaggg agctggctct   4440

gcaaatgaaa accaacctaa aaagatgttc acttccagtg tccataaaca ggagaagaca   4500

gcacagatga agccacctaa gcctacaaaa tcagttggat ttgaagctca gaagatactg   4560

caagttcctg ccatggaaaa agaaaccaaa cgatcttcaa ctctcccagc caagttccag   4620

aacccagttg agccaattga gcctgtctgg ttctcactgg ccaggaagaa agccaaagca   4680

tggagccaca tggcagaaat cacgcaataa agagctcttg tgtggagcat cagcatttat   4740

tttatttagt tttttttttt tttttttttt ttgagacaga gtctcgctct gttacccaga   4800

ttggagtgca gtggcgcgat ctccgctcac tgcaagctcc gcctcccggg ttcacgccac   4860

tctcccgcct cagtctcccg actagctggg actacaggcg cccgccatca cgcccggcta   4920

attttgtttt cgtattttta gtagagacgg ggtttcacca tgttggccag gatggtcttg   4980

atctcctgac ctcgtgatcc gcccgcctca gcctcccaaa agctgggatt acaggcgtga   5040

gccaccgcgc ccggccaagc atcagcgttt taaatgataa ttgctaatag ctgtattaat   5100

tctatgtagt gatcttttta ctgtgaccac ttgtattaag caaaataagt attaagcaaa   5160

ctaagaattt attaagcaaa ataagaattt attaagcaaa atagccttag aaatgcaaat   5220

taaaacataa ttatttgaat gaaataaatg ccatgaatgc ttaaccttcc acgtagtcac   5280

tgccagcacc cagaaaccca gcatttcctc tattaaaact atcgaaaaca tttgcactgc   5340

tgtaaaattg caaaatcttt aactttggac aatgtgcttt agaagggaga aagcaaaaac   5400

attttgttgg agcaactaga aaattgtcat ttccctcaac caaataaagt aattctaatg   5460

gaaacattca gatgatttga cctaaagatt ggcctttagg ttttatgagc ctagatagat   5520

gccgcaatta tttggttgtt gctctaagct ttgcaaggga tcctaaaaga ggcggtggaa   5580

gtgaaaattc tgggtctcca agaaaatttc tgcacagcca gttctccaat cagcctatca   5640

ccccttgaaa catcttccct gtgtccctgg gggcccctga tgctttctcc ttgggtgata   5700

gtaacatgca gagcacttac acaaagctcc ctctttggac ataccccacg tcgacctgtc   5760

acaggcctgg ctgtagcgag cacctcccta tgacgcagaa tgcttcttgg gaattatctt   5820

actcctctgg agggttagtc catcaatgtt ttgcttcttg tcccaatact actgtgaccc   5880

tctctgatcg cacagaaatc actgcctatc acatatatcc tgttaagcac tgaagaccct   5940

attgaaatta gagttctaca gatgccaaaa gctgtacttt ccatcaggca gatggcaagc   6000

ttactgcctt gatgcacatc tggagccact ggagctcctt cctctctggt tccagcatta   6060

aggtggagaa ctccatgtag cttcttgtcc tttcccctca gctgtctttg cttcacaagg   6120

ttttagccca aagcaagagt gcaatcccaa agccacagag aaatgaactt tccgctacct   6180

ggaagcttta agtgagtaaa tcagcttttc ccctctcatt cctagaggca cacacctcaa   6240

aagttactag gctggagaga ccctaccttc cagtgaccca ctcatccccc agccacggag   6300

aagagggaag accaaaaagg gagagtgaga aagaggatga gagggatggt cagctgtgag   6360

gggagggggc aagtggccca gcaaatgttg atgcctccct tcccatcttg ccacacggtc   6420

tttttctttt gtagcacagc ctccattaat aactcctcgg ctgaggatga agatgtaggc   6480

acctttaccc ccagagccag ttccttaatt ggctggcttt ctgagatgca gaccacccta   6540

gaatctcatc taggttcact agaagttagt taaatcttcc tttctctgtc tttctcttca   6600

ttccatcccc caaacccacc aaacactaag ggagagctcc ctttggatgt ctgggcagta   6660

aacctagctc atttttctag gagacccaga agtgacttct gagtagttat cactgtgtct   6720

gcctctgtta cactgtgctg ctttgcttaa acagaaatgc aggcctggac atctgactgt   6780

gcctttatat tctgagtggg gtgctgcccc atgcaaaaaa atccagagag gtagtgaggt   6840

gtcagagcta aacacttggt gctgggtttt gttgatgctg gtataatgtg acacagtaca   6900

attacatgct aaattttgca ttttctctat ataacatcta tttttcctga tactgtgcct   6960

ttgccatttt gataatgcta ttttgattga gtgaatttta tttcctttgt attcccatag   7020

tgaacaatat attaaggtag atgcccttta tctgggtact cctggtagat tagctgttac   7080

acctcccttc ccttttttac agtgaacctg tattcagtta ttgtcactct gagaactctc   7140

caataacaat ttcttttcca cagttaacaa cacagctgtt acacctccct tccttttttt   7200

cacagtgaac ctgtattcag ctattctcac tctgagaact ctccaataac aatttctttt   7260

ccacagttaa caacaaagtt ctgtttttaa atgaagagat taagttcttt ttaaatgcct   7320

aaaggcatat tctgacaact tttctacttc tttaactttt ttgatttaag atatatgcaa   7380

agcaaataaa ttcaataa                                                 7398


<210>  4247
<211>  1569
<212>  PRT
<213>  Homosapiens

<400>  4247

Met Ala Glu Ser Leu Ser Glu Ile Ser Asp Ser Leu Asp Val Leu Glu 
1               5                   10                  15      


Ala Gly Asp Glu Gly Lys Lys Lys Cys Lys Phe Lys Ala Leu Lys Ser 
            20                  25                  30          


Phe Phe Val Lys Lys Lys Glu Lys Glu Ala Glu Asp Thr Gln Glu Glu 
        35                  40                  45              


Glu Met Leu Glu Leu Ser Leu Ser Ser Ser Asn Ile Asn Ile Ser Ser 
    50                  55                  60                  


Leu Gln Pro Val Arg Glu Asn Gln Pro Thr Lys Ala Arg Ala Lys Ser 
65                  70                  75                  80  


Ser Met Gly Ser Lys Ala Leu Ser His Asp Ser Ile Phe Met Leu Gly 
                85                  90                  95      


Pro Glu Pro Glu Arg Ser Ala Ser Lys Met Phe Pro Ser Met Asp Pro 
            100                 105                 110         


Gln Arg Gly Arg Pro Gln Gln Arg Ser His Ile Ser Arg Thr Leu Pro 
        115                 120                 125             


Lys Pro Arg Ser Lys Val Pro Gly Val Val Ser Gly Ala Met Ser Gly 
    130                 135                 140                 


Ala Val Leu Gln Asn Val Pro Thr Ser Ala Val Trp Val Ala Gly Pro 
145                 150                 155                 160 


Lys Ile Thr Glu Asn Pro Pro Ser Arg Arg Arg Arg Leu Ser Ile Ile 
                165                 170                 175     


Pro Pro Val Ile Gln Pro Glu Ile Ile Ser Lys Asn Leu Val Glu Ile 
            180                 185                 190         


Ser Leu Asp Asp Glu Ser Pro Lys Asn Pro Gln Lys Lys Ala Leu Pro 
        195                 200                 205             


His Lys Ser Leu Thr Ala Thr Gln Ser Phe Ser Glu Leu Ser Ser Gly 
    210                 215                 220                 


Pro Asp Cys Ser Gln Ser Leu Thr Ala Phe Ala Thr Leu Ala Ser Thr 
225                 230                 235                 240 


Ser Ser Thr Gln Leu Pro Ile Gly Phe Ser Thr Pro Ala Thr Thr Gln 
                245                 250                 255     


Gly Cys Leu Asp Ser Ser Ala Ala Arg His Lys Met Thr Leu Asn Pro 
            260                 265                 270         


Arg Lys Gln Lys Lys Asn Leu Gln Val Ile Ile Arg Gly Leu Pro Val 
        275                 280                 285             


Trp Phe Ser His Phe Gln Gly Ile Leu Glu Gly Ser Leu Gln Cys Val 
    290                 295                 300                 


Thr Gln Thr Leu Glu Thr Pro Asn Leu Asp Glu Pro Leu Pro Val Glu 
305                 310                 315                 320 


Pro Lys Glu Glu Glu Pro Asn Leu Pro Leu Val Ser Glu Glu Glu Lys 
                325                 330                 335     


Ser Ile Thr Lys Pro Lys Glu Ile Asn Glu Lys Lys Leu Gly Met Asp 
            340                 345                 350         


Ser Ala Asp Ser Ser Ser Gln Lys Gln Asn Asn Lys Thr Glu Met Tyr 
        355                 360                 365             


Asp Lys Lys Thr Thr Asp Gln Ala Pro Asn Thr Asp Ala Ser Arg Ser 
    370                 375                 380                 


Gln Gly Tyr Pro Met Ser Ala Ala Tyr Gly Arg Arg Trp Arg Arg Lys 
385                 390                 395                 400 


Gly Ala Ser Val Ser Gly Leu Ser Gly Cys Glu Phe Lys Gly Arg Ser 
                405                 410                 415     


Leu Lys Gln Ser Ser Glu Gly Tyr Gly Leu Gly Asp Arg Ala Gly Ser 
            420                 425                 430         


Ser Pro Thr Asn Lys Thr Ala Arg Asn Val Pro Phe Ser His Leu Ser 
        435                 440                 445             


Leu Glu Lys Asp Asn Met Glu Gln Pro Thr Thr Ser Gln Pro Glu Thr 
    450                 455                 460                 


Thr Thr Pro Gln Gly Leu Leu Ser Asp Lys Asp Asp Met Gly Arg Arg 
465                 470                 475                 480 


Asn Ala Gly Ile Asp Phe Gly Ser Arg Lys Ala Ser Ala Ala Gln Pro 
                485                 490                 495     


Ile Pro Glu Asn Met Asp Asn Ser Met Val Ser Asp Pro Gln Pro Tyr 
            500                 505                 510         


His Glu Asp Ala Ala Ser Gly Ala Glu Lys Thr Glu Ala Arg Ala Ser 
        515                 520                 525             


Leu Ser Leu Met Val Glu Ser Leu Ser Thr Thr Gln Glu Glu Ala Ile 
    530                 535                 540                 


Leu Ser Val Ala Ala Glu Ala Gln Val Phe Met Asn Pro Ser His Ile 
545                 550                 555                 560 


Gln Leu Glu Asp Gln Glu Ala Phe Ser Phe Asp Leu Gln Lys Ala Gln 
                565                 570                 575     


Ser Lys Met Glu Ser Ala Gln Asp Val Gln Thr Ile Cys Lys Glu Lys 
            580                 585                 590         


Pro Ser Gly Asn Val His Gln Thr Phe Thr Ala Ser Val Leu Gly Met 
        595                 600                 605             


Thr Ser Thr Thr Ala Lys Gly Asp Val Tyr Ala Lys Thr Leu Pro Pro 
    610                 615                 620                 


Arg Ser Leu Phe Gln Ser Ser Arg Lys Pro Asp Ala Glu Glu Val Ser 
625                 630                 635                 640 


Ser Asp Ser Glu Asn Ile Pro Glu Glu Gly Asp Gly Ser Glu Glu Leu 
                645                 650                 655     


Ala His Gly His Ser Ser Gln Ser Leu Gly Lys Phe Glu Asp Glu Gln 
            660                 665                 670         


Glu Val Phe Ser Glu Ser Lys Ser Phe Val Glu Asp Leu Ser Ser Ser 
        675                 680                 685             


Glu Glu Glu Leu Asp Leu Arg Cys Leu Ser Gln Ala Leu Glu Glu Pro 
    690                 695                 700                 


Glu Asp Ala Glu Val Phe Thr Glu Ser Ser Ser Tyr Val Glu Lys Tyr 
705                 710                 715                 720 


Asn Thr Ser Asp Asp Cys Ser Ser Ser Glu Glu Asp Leu Pro Leu Arg 
                725                 730                 735     


His Pro Ala Gln Ala Leu Gly Lys Pro Lys Asn Gln Gln Glu Val Ser 
            740                 745                 750         


Ser Ala Ser Asn Asn Thr Pro Glu Glu Gln Asn Asp Phe Met Gln Gln 
        755                 760                 765             


Leu Pro Ser Arg Cys Pro Ser Gln Pro Ile Met Asn Pro Thr Val Gln 
    770                 775                 780                 


Gln Gln Val Pro Thr Ser Ser Val Gly Thr Ser Ile Lys Gln Ser Asp 
785                 790                 795                 800 


Ser Val Glu Pro Ile Pro Pro Arg His Pro Phe Gln Pro Trp Val Asn 
                805                 810                 815     


Pro Lys Val Glu Gln Glu Val Ser Ser Ser Pro Lys Ser Met Ala Val 
            820                 825                 830         


Glu Glu Ser Ile Ser Met Lys Pro Leu Pro Pro Lys Leu Leu Cys Gln 
        835                 840                 845             


Pro Leu Met Asn Pro Lys Val Gln Gln Asn Met Phe Ser Gly Ser Glu 
    850                 855                 860                 


Asp Ile Ala Val Glu Arg Val Ile Ser Val Glu Pro Leu Leu Pro Arg 
865                 870                 875                 880 


Tyr Ser Pro Gln Ser Leu Thr Asp Pro Gln Ile Arg Gln Ile Ser Glu 
                885                 890                 895     


Ser Thr Ala Val Glu Glu Gly Thr Tyr Val Glu Pro Leu Pro Pro Arg 
            900                 905                 910         


Cys Leu Ser Gln Pro Ser Glu Arg Pro Lys Phe Leu Asp Ser Met Ser 
        915                 920                 925             


Thr Ser Ala Glu Trp Ser Ser Pro Val Ala Pro Thr Pro Ser Lys Tyr 
    930                 935                 940                 


Thr Ser Pro Pro Trp Val Thr Pro Lys Phe Glu Glu Leu Tyr Gln Leu 
945                 950                 955                 960 


Ser Ala His Pro Glu Ser Thr Thr Val Glu Glu Asp Ile Ser Lys Glu 
                965                 970                 975     


Gln Leu Leu Pro Arg His Leu Ser Gln Leu Thr Val Gly Asn Lys Val 
            980                 985                 990         


Gln Gln Leu Ser Ser Asn Phe Glu  Arg Ala Ala Ile Glu  Ala Asp Ile 
        995                 1000                 1005             


Ser Gly  Ser Pro Leu Pro Pro  Gln Tyr Ala Thr Gln  Phe Leu Lys 
    1010                 1015                 1020             


Arg Ser  Lys Val Gln Glu Met  Thr Ser Arg Leu Glu  Lys Met Ala 
    1025                 1030                 1035             


Val Glu  Gly Thr Ser Asn Lys  Ser Pro Ile Pro Arg  Arg Pro Thr 
    1040                 1045                 1050             


Gln Ser  Phe Val Lys Phe Met  Ala Gln Gln Ile Phe  Ser Glu Ser 
    1055                 1060                 1065             


Ser Ala  Leu Lys Arg Gly Ser  Asp Val Ala Pro Leu  Pro Pro Asn 
    1070                 1075                 1080             


Leu Pro  Ser Lys Ser Leu Ser  Lys Pro Glu Val Lys  His Gln Val 
    1085                 1090                 1095             


Phe Ser  Asp Ser Gly Ser Ala  Asn Pro Lys Gly Gly  Ile Ser Ser 
    1100                 1105                 1110             


Lys Met  Leu Pro Met Lys His  Pro Leu Gln Ser Leu  Gly Arg Pro 
    1115                 1120                 1125             


Glu Asp  Pro Gln Lys Val Phe  Ser Tyr Ser Glu Arg  Ala Pro Gly 
    1130                 1135                 1140             


Lys Cys  Ser Ser Phe Lys Glu  Gln Leu Ser Pro Arg  Gln Leu Ser 
    1145                 1150                 1155             


Gln Ala  Leu Arg Lys Pro Glu  Tyr Glu Gln Lys Val  Ser Pro Val 
    1160                 1165                 1170             


Ser Ala  Ser Ser Pro Lys Glu  Trp Arg Asn Ser Lys  Lys Gln Leu 
    1175                 1180                 1185             


Pro Pro  Lys His Ser Ser Gln  Ala Ser Asp Arg Ser  Lys Phe Gln 
    1190                 1195                 1200             


Pro Gln  Met Ser Ser Lys Gly  Pro Val Asn Val Pro  Val Lys Gln 
    1205                 1210                 1215             


Ser Ser  Gly Glu Lys His Leu  Pro Ser Ser Ser Pro  Phe Gln Gln 
    1220                 1225                 1230             


Gln Val  His Ser Ser Ser Val  Asn Ala Ala Ala Arg  Arg Ser Val 
    1235                 1240                 1245             


Phe Glu  Ser Asn Ser Asp Asn  Trp Phe Leu Gly Arg  Asp Glu Ala 
    1250                 1255                 1260             


Phe Ala  Ile Lys Thr Lys Lys  Phe Ser Gln Gly Ser  Lys Asn Pro 
    1265                 1270                 1275             


Ile Lys  Ser Ile Pro Ala Pro  Ala Thr Lys Pro Gly  Lys Phe Thr 
    1280                 1285                 1290             


Ile Ala  Pro Val Arg Gln Thr  Ser Thr Ser Gly Gly  Ile Tyr Ser 
    1295                 1300                 1305             


Lys Lys  Glu Asp Leu Glu Ser  Gly Asp Gly Asn Asn  Asn Gln His 
    1310                 1315                 1320             


Ala Asn  Leu Ser Asn Gln Asp  Asp Val Glu Lys Leu  Phe Gly Val 
    1325                 1330                 1335             


Arg Leu  Lys Arg Ala Pro Pro  Ser Gln Lys Tyr Lys  Ser Glu Lys 
    1340                 1345                 1350             


Gln Asp  Asn Phe Thr Gln Leu  Ala Ser Val Pro Ser  Gly Pro Ile 
    1355                 1360                 1365             


Ser Ser  Ser Val Gly Arg Gly  His Lys Ile Arg Ser  Thr Ser Gln 
    1370                 1375                 1380             


Gly Leu  Leu Asp Ala Ala Gly  Asn Leu Thr Lys Ile  Ser Tyr Val 
    1385                 1390                 1395             


Ala Asp  Lys Gln Gln Ser Arg  Pro Lys Ser Glu Ser  Met Ala Lys 
    1400                 1405                 1410             


Lys Gln  Pro Ala Cys Lys Thr  Pro Gly Lys Pro Ala  Gly Gln Gln 
    1415                 1420                 1425             


Ser Asp  Tyr Ala Val Ser Glu  Pro Val Trp Ile Thr  Met Ala Lys 
    1430                 1435                 1440             


Gln Lys  Gln Lys Ser Phe Lys  Ala His Ile Ser Val  Lys Glu Leu 
    1445                 1450                 1455             


Lys Thr  Lys Ser Asn Ala Gly  Ala Asp Ala Glu Thr  Lys Glu Pro 
    1460                 1465                 1470             


Lys Tyr  Glu Gly Ala Gly Ser  Ala Asn Glu Asn Gln  Pro Lys Lys 
    1475                 1480                 1485             


Met Phe  Thr Ser Ser Val His  Lys Gln Glu Lys Thr  Ala Gln Met 
    1490                 1495                 1500             


Lys Pro  Pro Lys Pro Thr Lys  Ser Val Gly Phe Glu  Ala Gln Lys 
    1505                 1510                 1515             


Ile Leu  Gln Val Pro Ala Met  Glu Lys Glu Thr Lys  Arg Ser Ser 
    1520                 1525                 1530             


Thr Leu  Pro Ala Lys Phe Gln  Asn Pro Val Glu Pro  Ile Glu Pro 
    1535                 1540                 1545             


Val Trp  Phe Ser Leu Ala Arg  Lys Lys Ala Lys Ala  Trp Ser His 
    1550                 1555                 1560             


Met Ala  Glu Ile Thr Gln 
    1565                 


<210>  4248
<211>  3148
<212>  DNA
<213>  Homosapiens

<400>  4248
agagcgagcg aataagagag agagtaagag ggagagagaa gaagaggaag aagaggaggc     60

ggcggcagcg gaggaggagg aggactagtg tggggtggaa aggaagagtg agcgagagca    120

agttaagggg agggggtgta agagccagcg aattcttttt ctttttctat tattattttg    180

acgactcctg agttgcgccc atgctcttgt cagcttcgtt ttaggcgtag catggccagg    240

cagaagaaaa tggggcaaag cgtgctccgg gcggtcttct ttttagtcct ggggcttttg    300

ggtcattctc acggaggatt ccccaacacc atcagcatag gtggactttt catgagaaac    360

acagtgcagg agcacagcgc tttccgcttt gccgtgcagt tatacaacac caaccagaac    420

accaccgaga agcccttcca tttgaattac cacgtagatc acttggattc ctccaatagt    480

ttttccgtga caaatgcttt ctgctcccag ttctcgagag gggtgtatgc catctttgga    540

ttctatgacc agatgtcaat gaacaccctg acctccttct gtggggccct gcacacatcc    600

tttgttacgc ctagcttccc cactgacgca gatgtgcagt ttgtcatcca gatgcgccca    660

gccttgaagg gcgctattct gagtcttctg ggtcattaca agtgggagaa gtttgtgtac    720

ctctatgaca cagaacgagg attttccatc ctccaagcga ttatggaagc agcagtgcaa    780

aacaactggc aagtaacagc aaggtctgtg ggaaacataa aggacgtcca agaattcagg    840

cgcatcattg aagaaatgga caggaggcag gaaaagcgat acttgattga ctgcgaagtc    900

gaaaggatta acacaatttt ggaacaggtt gtgatcctag ggaaacactc aagaggttat    960

cactacatgc tcgctaacct gggttttact gatattttac tggaaagagt catgcatggg   1020

ggagccaaca ttacaggttt ccagattgtc aacaatgaaa accctatggt tcagcagttc   1080

atacagcgct gggtgaggct ggatgaaagg gaattccctg aagccaagaa tgcaccacta   1140

aagtatacat ctgcattgac acacgacgca atactggtca tagcagaagc tttccgctac   1200

ctgaggaggc agcgagtaga tgtgtcccgg agaggaagtg ctggagactg cttagcaaat   1260

cctgctgtgc cctggagtca aggaattgat attgagagag ctctgaaaat ggtgcaagta   1320

caaggaatga ctggaaatat tcaatttgac acttatggac gtaggacaaa ttataccatc   1380

gatgtgtatg aaatgaaagt cagtggctct cgaaaagctg gctactggaa cgagtatgaa   1440

aggtttgtgc ctttctcaga tcagcaaatc agcaatgaca gtgcatcctc agagaatcgg   1500

accatagtag tgactaccat tctggaatca ccatatgtaa tgtacaagaa gaaccatgag   1560

caactggaag gaaatgaacg atatgaaggc tattgtgtag acctagccta tgaaatagcc   1620

aaacatgtaa ggatcaaata caaattgtcc atcgttggtg acgggaaata tggtgcaagg   1680

gatccagaga ctaaaatatg gaacggcatg gttggggaac ttgtctatgg gagagctgat   1740

atagctgttg ctccactcac tataacattg gtccgtgaag aagtcataga tttttcaaag   1800

ccattcatga gcctgggcat ctccatcatg ataaagaagc ctcagaaatc aaaaccaggc   1860

gtattctcat ttctggatcc cctggcttat gaaatctgga tgtgcattgt ctttgcttac   1920

attggagtca gcgtagttct tttcctagtc agcaggttca gtccttatga atggcacttg   1980

gaagacaaca atgaagaacc tcgtgaccca caaagtcctc ctgatcctcc aaatgaattt   2040

ggaatattta acagtctttg gttttccttg ggtgccttta tgcagcaagg atgtgatatt   2100

tctccaagat cactctccgg gcgcattgtt ggaggggttt ggtggttctt caccctgatc   2160

ataatttctt cctatactgc caatctcgct gctttcctga ctgtggagag gatggtttct   2220

cccatagaga gtgctgaaga cttagctaaa cagactgaaa ttgcatatgg gaccctggac   2280

tccggttcaa caaaagaatt tttcagaaga tccaaaattg ctgtgtacga gaaaatgtgg   2340

tcttacatga aatcagcgga gccatctgtg tttaccaaaa caacagcaga cggagtggcc   2400

cgagtgcgaa agtccaaggg aaagttcgcc ttcctgctgg agtcaaccat gaatgagtac   2460

attgagcaga gaaaaccatg tgatacgatg aaagttggtg gaaatctgga ttccaaaggc   2520

tatggtgtgg caacccctaa aggctcagca ttaggaaatg ctgttaacct ggcagtatta   2580

aaactgaatg agcaaggcct cttggacaaa ttgaaaaaca aatggtggta cgacaaagga   2640

gagtgcggca gcgggggcgg tgactccaag gacaagacca gcgctctgag cctgagcaat   2700

gtggcaggcg ttttctatat acttgtcgga ggtctggggc tggccatgat ggtggctttg   2760

atagaattct gttacaaatc acgggcagag tccaaacgca tgaaactcac aaagaacacc   2820

caaaacttta agcctgctcc tgccaccaac actcagaatt atgctacata cagagaaggc   2880

tacaacgtgt atggaacaga gagtgttaag atctagggat cccttcccac tggaggcatg   2940

tgatgagagg aaatcaccga aaacgtggct gcttcaagga tcctgagcca gatttcactc   3000

tccttggtgt cgggcatgac acgaatattg ctgatggtgc aatgaccttt caataggaaa   3060

aactgatttt tttttccttc agtgccttat ggaacactct gagactcgcg acaatgcaaa   3120

ccatcattga aatctttttg ctttgctt                                      3148


<210>  4249
<211>  894
<212>  PRT
<213>  Homosapiens

<400>  4249

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg 
                85                  90                  95      


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Gln Met Ser Met Asn Thr 
            100                 105                 110         


Leu Thr Ser Phe Cys Gly Ala Leu His Thr Ser Phe Val Thr Pro Ser 
        115                 120                 125             


Phe Pro Thr Asp Ala Asp Val Gln Phe Val Ile Gln Met Arg Pro Ala 
    130                 135                 140                 


Leu Lys Gly Ala Ile Leu Ser Leu Leu Gly His Tyr Lys Trp Glu Lys 
145                 150                 155                 160 


Phe Val Tyr Leu Tyr Asp Thr Glu Arg Gly Phe Ser Ile Leu Gln Ala 
                165                 170                 175     


Ile Met Glu Ala Ala Val Gln Asn Asn Trp Gln Val Thr Ala Arg Ser 
            180                 185                 190         


Val Gly Asn Ile Lys Asp Val Gln Glu Phe Arg Arg Ile Ile Glu Glu 
        195                 200                 205             


Met Asp Arg Arg Gln Glu Lys Arg Tyr Leu Ile Asp Cys Glu Val Glu 
    210                 215                 220                 


Arg Ile Asn Thr Ile Leu Glu Gln Val Val Ile Leu Gly Lys His Ser 
225                 230                 235                 240 


Arg Gly Tyr His Tyr Met Leu Ala Asn Leu Gly Phe Thr Asp Ile Leu 
                245                 250                 255     


Leu Glu Arg Val Met His Gly Gly Ala Asn Ile Thr Gly Phe Gln Ile 
            260                 265                 270         


Val Asn Asn Glu Asn Pro Met Val Gln Gln Phe Ile Gln Arg Trp Val 
        275                 280                 285             


Arg Leu Asp Glu Arg Glu Phe Pro Glu Ala Lys Asn Ala Pro Leu Lys 
    290                 295                 300                 


Tyr Thr Ser Ala Leu Thr His Asp Ala Ile Leu Val Ile Ala Glu Ala 
305                 310                 315                 320 


Phe Arg Tyr Leu Arg Arg Gln Arg Val Asp Val Ser Arg Arg Gly Ser 
                325                 330                 335     


Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Ser Gln Gly Ile 
            340                 345                 350         


Asp Ile Glu Arg Ala Leu Lys Met Val Gln Val Gln Gly Met Thr Gly 
        355                 360                 365             


Asn Ile Gln Phe Asp Thr Tyr Gly Arg Arg Thr Asn Tyr Thr Ile Asp 
    370                 375                 380                 


Val Tyr Glu Met Lys Val Ser Gly Ser Arg Lys Ala Gly Tyr Trp Asn 
385                 390                 395                 400 


Glu Tyr Glu Arg Phe Val Pro Phe Ser Asp Gln Gln Ile Ser Asn Asp 
                405                 410                 415     


Ser Ala Ser Ser Glu Asn Arg Thr Ile Val Val Thr Thr Ile Leu Glu 
            420                 425                 430         


Ser Pro Tyr Val Met Tyr Lys Lys Asn His Glu Gln Leu Glu Gly Asn 
        435                 440                 445             


Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Tyr Glu Ile Ala Lys 
    450                 455                 460                 


His Val Arg Ile Lys Tyr Lys Leu Ser Ile Val Gly Asp Gly Lys Tyr 
465                 470                 475                 480 


Gly Ala Arg Asp Pro Glu Thr Lys Ile Trp Asn Gly Met Val Gly Glu 
                485                 490                 495     


Leu Val Tyr Gly Arg Ala Asp Ile Ala Val Ala Pro Leu Thr Ile Thr 
            500                 505                 510         


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
        515                 520                 525             


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
    530                 535                 540                 


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
545                 550                 555                 560 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
                565                 570                 575     


Ser Pro Tyr Glu Trp His Leu Glu Asp Asn Asn Glu Glu Pro Arg Asp 
            580                 585                 590         


Pro Gln Ser Pro Pro Asp Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser 
        595                 600                 605             


Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser 
    610                 615                 620                 


Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe 
625                 630                 635                 640 


Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala 
            660                 665                 670         


Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys 
        675                 680                 685             


Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Ser 
    690                 695                 700                 


Tyr Met Lys Ser Ala Glu Pro Ser Val Phe Thr Lys Thr Thr Ala Asp 
705                 710                 715                 720 


Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu 
                725                 730                 735     


Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr 
            740                 745                 750         


Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr 
        755                 760                 765             


Pro Lys Gly Ser Ala Leu Gly Asn Ala Val Asn Leu Ala Val Leu Lys 
    770                 775                 780                 


Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr 
785                 790                 795                 800 


Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp Ser Lys Asp Lys Thr 
                805                 810                 815     


Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Val 
            820                 825                 830         


Gly Gly Leu Gly Leu Ala Met Met Val Ala Leu Ile Glu Phe Cys Tyr 
        835                 840                 845             


Lys Ser Arg Ala Glu Ser Lys Arg Met Lys Leu Thr Lys Asn Thr Gln 
    850                 855                 860                 


Asn Phe Lys Pro Ala Pro Ala Thr Asn Thr Gln Asn Tyr Ala Thr Tyr 
865                 870                 875                 880 


Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu Ser Val Lys Ile 
                885                 890                 


<210>  4250
<211>  3148
<212>  DNA
<213>  Homosapiens

<400>  4250
agagcgagcg aataagagag agagtaagag ggagagagaa gaagaggaag aagaggaggc     60

ggcggcagcg gaggaggagg aggactagtg tggggtggaa aggaagagtg agcgagagca    120

agttaagggg agggggtgta agagccagcg aattcttttt ctttttctat tattattttg    180

acgactcctg agttgcgccc atgctcttgt cagcttcgtt ttaggcgtag catggccagg    240

cagaagaaaa tggggcaaag cgtgctccgg gcggtcttct ttttagtcct ggggcttttg    300

ggtcattctc acggaggatt ccccaacacc atcagcatag gtggactttt catgagaaac    360

acagtgcagg agcacagcgc tttccgcttt gccgtgcagt tatacaacac caaccagaac    420

accaccgaga agcccttcca tttgaattac cacgtagatc acttggattc ctccaatagt    480

ttttccgtga caaatgcttt ctgctcccag ttctcgagag gggtgtatgc catctttgga    540

ttctatgacc agatgtcaat gaacaccctg acctccttct gtggggccct gcacacatcc    600

tttgttacgc ctagcttccc cactgacgca gatgtgcagt ttgtcatcca gatgcgccca    660

gccttgaagg gcgctattct gagtcttctg ggtcattaca agtgggagaa gtttgtgtac    720

ctctatgaca cagaacgagg attttccatc ctccaagcga ttatggaagc agcagtgcaa    780

aacaactggc aagtaacagc aaggtctgtg ggaaacataa aggacgtcca agaattcagg    840

cgcatcattg aagaaatgga caggaggcag gaaaagcgat acttgattga ctgcgaagtc    900

gaaaggatta acacaatttt ggaacaggtt gtgatcctag ggaaacactc aagaggttat    960

cactacatgc tcgctaacct gggttttact gatattttac tggaaagagt catgcatggg   1020

ggagccaaca ttacaggttt ccagattgtc aacaatgaaa accctatggt tcagcagttc   1080

atacagcgct gggtgaggct ggatgaaagg gaattccctg aagccaagaa tgcaccacta   1140

aagtatacat ctgcattgac acacgacgca atactggtca tagcagaagc tttccgctac   1200

ctgaggaggc agcgagtaga tgtgtcccgg agaggaagtg ctggagactg cttagcaaat   1260

cctgctgtgc cctggagtca aggaattgat attgagagag ctctgaaaat ggtgcaagta   1320

caaggaatga ctggaaatat tcaatttgac acttatggac gtaggacaaa ttataccatc   1380

gatgtgtatg aaatgaaagt cagtggctct cgaaaagctg gctactggaa cgagtatgaa   1440

aggtttgtgc ctttctcaga tcagcaaatc agcaatgaca gtgcatcctc agagaatcgg   1500

accatagtag tgactaccat tctggaatca ccatatgtaa tgtacaagaa gaaccatgag   1560

caactggaag gaaatgaacg atatgaaggc tattgtgtag acctagccta tgaaatagcc   1620

aaacatgtaa ggatcaaata caaattgtcc atcgttggtg acgggaaata tggtgcaagg   1680

gatccagaga ctaaaatatg gaacggcatg gttggggaac ttgtctatgg gagagctgat   1740

atagctgttg ctccactcac tataacattg gtccgtgaag aagtcataga tttttcaaag   1800

ccattcatga gcctgggcat ctccatcatg ataaagaagc ctcagaaatc aaaaccaggc   1860

gtattctcat ttctggatcc cctggcttat gaaatctgga tgtgcattgt ctttgcttac   1920

attggagtca gcgtagttct tttcctagtc agcaggttca gtccttatga atggcacttg   1980

gaagacaaca atgaagaacc tcgtgaccca caaagtcctc ctgatcctcc aaatgaattt   2040

ggaatattta acagtctttg gttttccttg ggtgccttta tgcagcaagg atgtgatatt   2100

tctccaagat cactctccgg gcgcattgtt ggaggggttt ggtggttctt caccctgatc   2160

ataatttctt cctatactgc caatctcgct gctttcctga ctgtggagag gatggtttct   2220

cccatagaga gtgctgaaga cttagctaaa cagactgaaa ttgcatatgg gaccctggac   2280

tccggttcaa caaaagaatt tttcagaaga tccaaaattg ctgtgtacga gaaaatgtgg   2340

tcttacatga aatcagcgga gccatctgtg tttaccaaaa caacagcaga cggagtggcc   2400

cgagtgcgaa agtccaaggg aaagttcgcc ttcctgctgg agtcaaccat gaatgagtac   2460

attgagcaga gaaaaccatg tgatacgatg aaagttggtg gaaatctgga ttccaaaggc   2520

tatggtgtgg caacccctaa aggctcagca ttaggaacgc ctgtaaacct tgcagtattg   2580

aaactcagtg aacaaggcat cttagacaag ctgaaaaaca aatggtggta cgataagggg   2640

gaatgtggag ccaaggactc cgggagtaag gacaagacca gcgctctgag cctgagcaat   2700

gtggcaggcg ttttctatat acttgtcgga ggtctggggc tggccatgat ggtggctttg   2760

atagaattct gttacaaatc acgggcagag tccaaacgca tgaaactcac aaagaacacc   2820

caaaacttta agcctgctcc tgccaccaac actcagaatt atgctacata cagagaaggc   2880

tacaacgtgt atggaacaga gagtgttaag atctagggat cccttcccac tggaggcatg   2940

tgatgagagg aaatcaccga aaacgtggct gcttcaagga tcctgagcca gatttcactc   3000

tccttggtgt cgggcatgac acgaatattg ctgatggtgc aatgaccttt caataggaaa   3060

aactgatttt tttttccttc agtgccttat ggaacactct gagactcgcg acaatgcaaa   3120

ccatcattga aatctttttg ctttgctt                                      3148


<210>  4251
<211>  894
<212>  PRT
<213>  Homosapiens

<400>  4251

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg 
                85                  90                  95      


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Gln Met Ser Met Asn Thr 
            100                 105                 110         


Leu Thr Ser Phe Cys Gly Ala Leu His Thr Ser Phe Val Thr Pro Ser 
        115                 120                 125             


Phe Pro Thr Asp Ala Asp Val Gln Phe Val Ile Gln Met Arg Pro Ala 
    130                 135                 140                 


Leu Lys Gly Ala Ile Leu Ser Leu Leu Gly His Tyr Lys Trp Glu Lys 
145                 150                 155                 160 


Phe Val Tyr Leu Tyr Asp Thr Glu Arg Gly Phe Ser Ile Leu Gln Ala 
                165                 170                 175     


Ile Met Glu Ala Ala Val Gln Asn Asn Trp Gln Val Thr Ala Arg Ser 
            180                 185                 190         


Val Gly Asn Ile Lys Asp Val Gln Glu Phe Arg Arg Ile Ile Glu Glu 
        195                 200                 205             


Met Asp Arg Arg Gln Glu Lys Arg Tyr Leu Ile Asp Cys Glu Val Glu 
    210                 215                 220                 


Arg Ile Asn Thr Ile Leu Glu Gln Val Val Ile Leu Gly Lys His Ser 
225                 230                 235                 240 


Arg Gly Tyr His Tyr Met Leu Ala Asn Leu Gly Phe Thr Asp Ile Leu 
                245                 250                 255     


Leu Glu Arg Val Met His Gly Gly Ala Asn Ile Thr Gly Phe Gln Ile 
            260                 265                 270         


Val Asn Asn Glu Asn Pro Met Val Gln Gln Phe Ile Gln Arg Trp Val 
        275                 280                 285             


Arg Leu Asp Glu Arg Glu Phe Pro Glu Ala Lys Asn Ala Pro Leu Lys 
    290                 295                 300                 


Tyr Thr Ser Ala Leu Thr His Asp Ala Ile Leu Val Ile Ala Glu Ala 
305                 310                 315                 320 


Phe Arg Tyr Leu Arg Arg Gln Arg Val Asp Val Ser Arg Arg Gly Ser 
                325                 330                 335     


Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Ser Gln Gly Ile 
            340                 345                 350         


Asp Ile Glu Arg Ala Leu Lys Met Val Gln Val Gln Gly Met Thr Gly 
        355                 360                 365             


Asn Ile Gln Phe Asp Thr Tyr Gly Arg Arg Thr Asn Tyr Thr Ile Asp 
    370                 375                 380                 


Val Tyr Glu Met Lys Val Ser Gly Ser Arg Lys Ala Gly Tyr Trp Asn 
385                 390                 395                 400 


Glu Tyr Glu Arg Phe Val Pro Phe Ser Asp Gln Gln Ile Ser Asn Asp 
                405                 410                 415     


Ser Ala Ser Ser Glu Asn Arg Thr Ile Val Val Thr Thr Ile Leu Glu 
            420                 425                 430         


Ser Pro Tyr Val Met Tyr Lys Lys Asn His Glu Gln Leu Glu Gly Asn 
        435                 440                 445             


Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Tyr Glu Ile Ala Lys 
    450                 455                 460                 


His Val Arg Ile Lys Tyr Lys Leu Ser Ile Val Gly Asp Gly Lys Tyr 
465                 470                 475                 480 


Gly Ala Arg Asp Pro Glu Thr Lys Ile Trp Asn Gly Met Val Gly Glu 
                485                 490                 495     


Leu Val Tyr Gly Arg Ala Asp Ile Ala Val Ala Pro Leu Thr Ile Thr 
            500                 505                 510         


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
        515                 520                 525             


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
    530                 535                 540                 


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
545                 550                 555                 560 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
                565                 570                 575     


Ser Pro Tyr Glu Trp His Leu Glu Asp Asn Asn Glu Glu Pro Arg Asp 
            580                 585                 590         


Pro Gln Ser Pro Pro Asp Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser 
        595                 600                 605             


Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser 
    610                 615                 620                 


Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe 
625                 630                 635                 640 


Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala 
            660                 665                 670         


Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys 
        675                 680                 685             


Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Ser 
    690                 695                 700                 


Tyr Met Lys Ser Ala Glu Pro Ser Val Phe Thr Lys Thr Thr Ala Asp 
705                 710                 715                 720 


Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu 
                725                 730                 735     


Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr 
            740                 745                 750         


Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr 
        755                 760                 765             


Pro Lys Gly Ser Ala Leu Gly Thr Pro Val Asn Leu Ala Val Leu Lys 
    770                 775                 780                 


Leu Ser Glu Gln Gly Ile Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr 
785                 790                 795                 800 


Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser Gly Ser Lys Asp Lys Thr 
                805                 810                 815     


Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Val 
            820                 825                 830         


Gly Gly Leu Gly Leu Ala Met Met Val Ala Leu Ile Glu Phe Cys Tyr 
        835                 840                 845             


Lys Ser Arg Ala Glu Ser Lys Arg Met Lys Leu Thr Lys Asn Thr Gln 
    850                 855                 860                 


Asn Phe Lys Pro Ala Pro Ala Thr Asn Thr Gln Asn Tyr Ala Thr Tyr 
865                 870                 875                 880 


Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu Ser Val Lys Ile 
                885                 890                 


<210>  4252
<211>  1005
<212>  DNA
<213>  Homosapiens

<400>  4252
agagcgagcg aataagagag agagtaagag ggagagagaa gaagaggaag aagaggaggc     60

ggcggcagcg gaggaggagg aggactagtg tggggtggaa aggaagagtg agcgagagca    120

agttaagggg agggggtgta agagccagcg aattcttttt ctttttctat tattattttg    180

acgactcctg agttgcgccc atgctcttgt cagcttcgtt ttaggcgtag catggccagg    240

cagaagaaaa tggggcaaag cgtgctccgg gcggtcttct ttttagtcct ggggcttttg    300

ggtcattctc acggaggatt ccccaacacc atcagcatag gtggactttt catgagaaac    360

acagtgcagg agcacagcgc tttccgcttt gccgtgcagt tatacaacac caaccagaac    420

accaccgaga agcccttcca tttgaattac cacgtagatc acttggattc ctccaatagt    480

ttttccgtga caaatgcttg tcctgctgaa agggactacc tgccttggcc aggaagcatc    540

agggaaaaca attggacagc tctgccgtgc tgcaaagatc atgggctgct gcacctaaaa    600

tgttcaccag gtggggcccg ccaaaactgg gcctattgta tctggggcgt tacaggtgaa    660

ctgtaagatg agaacaagat cacaagtcag cactacctcc tcccttcttg agttctcaac    720

tgagtgagca tcatggaggg agaagaaaga aagaagttca gcctgggtgt gtgaagctgt    780

aaagttgcag gttgaaccca aacccatttt agagacagaa gaaactaccc tctggagata    840

aaataaaaag atgaagctga gatgggacag gatcaaagtt gatgaaatat caagagaggt    900

taataaagga acattaattt attcctcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                   1005


<210>  4253
<211>  144
<212>  PRT
<213>  Homosapiens

<400>  4253

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Cys Pro Ala Glu Arg Asp Tyr 
                85                  90                  95      


Leu Pro Trp Pro Gly Ser Ile Arg Glu Asn Asn Trp Thr Ala Leu Pro 
            100                 105                 110         


Cys Cys Lys Asp His Gly Leu Leu His Leu Lys Cys Ser Pro Gly Gly 
        115                 120                 125             


Ala Arg Gln Asn Trp Ala Tyr Cys Ile Trp Gly Val Thr Gly Glu Leu 
    130                 135                 140                 


<210>  4254
<211>  4452
<212>  DNA
<213>  Homosapiens

<400>  4254
atgtttgttt cagacacagt tctaaaggaa cgcctggatc cagaaacact ggaatcatta     60

gggcttatca aacaatcaca gcaattcaat caaaagtcag ttaaaatcaa gacaaaactc    120

ttttataagc agcaaaaatt caatttgtta agagaagaga atgaaggtta tgccaagctg    180

attgctgaat tggggcaaga tttatctgga agtattacta gtgatttaat cttagaaaat    240

atcaaatctt taataggatg ctttaatctg gatcccaata gagttttgga tgtcatttta    300

gaagtgtttg aatgcaggcc agaacacgat gacttcttta tatctttgtt agaatcttac    360

atgagtatgt gtgaaccgca aacactgtgt catattcttg ggttcaaatt caagttttac    420

caggaaccaa atggcgagac accatcatct ttatacagag ttgcagcagt acttctacaa    480

tttaatctta ttgatttaga tgatctttat gtacatcttc ttccggctga taattgcatt    540

atggatgaac acaaacgaga aattgcggaa gctaagcaaa ttgttagaaa gcttacgatg    600

gttgtgttgt cttctgaaaa aatggatgag cgagagaaag aaaaggaaaa agaagaggag    660

aaagtagaga aaccacctga taaccaaaaa cttggcttgt tggaagcctt attaaagatt    720

ggtgattggc aacatgcaca gaacattatg gatcagatgc ctccatacta tgcagcttca    780

cacaagctaa tagcccttgc tatttgcaag ctcattcata taactattga gcctctctac    840

cgaagagttg gagttcctaa aggtgctaaa ggctcacctg ttaatgcttt gcaaaacaag    900

agagcaccaa aacaagctga gagctttgaa gatttgagga gagacgtgtt caatatgttc    960

tgttaccttg gtcctcacct ttctcacgat cccattttat ttgcaaaagt ggtgcgcata   1020

ggcaagtcat ttatgaagga gtttcagtct gatggaagca aacaagaaga taaagaaaaa   1080

acggaagtta tccttagctg tttgcttagc attactgacc aggtactact tccatctctt   1140

tctttgatgg actgcaatgc ttgtatgtct gaggaactat ggggaatgtt taaaacattt   1200

ccatatcagc atagatatcg tctgtatggc cagtggaaga atgaaactta taacagtcac   1260

ccacttttag taaaagttaa agctcaaaca atagacagag ccaaatatat catgaagcgc   1320

ctaaccaagg aaaatgtgaa gccttctgga agacaaattg ggaagttgag ccacagcaat   1380

ccaaccattt tgtttgatta tatcttgtca caaatacaga agtatgataa cttaataaca   1440

cctgtagtag attcattgaa atacctcact tcactgaatt atgatgtctt ggcctattgt   1500

atcattgaag ctttagctaa tccagaaaag gaaagaatga aacatgatga cacaaccatc   1560

tcaagctggc ttcagagtct ggctagtttc tgtggtgcag tttttcgtaa atatccaatt   1620

gatcttgctg gtcttcttca gtatgttgcc aatcagctaa aggcgggcaa aagttttgac   1680

ctgcttatat tgaaagaagt ggtacaaaaa atggcaggaa tagaaattac agaggaaatg   1740

acaatggagc aactagaggc tatgactggt ggagagcagc taaaagctga gggtggttat   1800

tttggtcaga tcagaaacac taaaaaatcc tctcagagat taaaggatgc tctattggac   1860

catgatcttg cccttcctct ctgtctgctt atggctcagc agagaaatgg ggtaatcttt   1920

caggaaggtg gagagaaaca tttgaaactt gtgggaaagc tctatgacca gtgtcatgat   1980

accctggtgc agtttggtgg gtttttagca tctaatctga gcacagaaga ttatataaag   2040

cgagtgcctt caattgatgt actctgtaat gaatttcata caccccatga tgcagcattt   2100

ttcctgtcta ggccaatgta tgcccatcat atttcgtcaa agtatgatga acttaaaaaa   2160

tcagaaaagg gaagtaaaca gcaacataaa gttcataagt acattacatc atgtgagatg   2220

gtgatggcgc ctgtccatga agcagtggtc tccttacatg tttccaaagt ctgggatgac   2280

atcagccctc aattctatgc tacattctgg tcattgacaa tgtatgacct tgcagttcca   2340

cacaccagct atgaacgaga agtcaataaa cttaaagtcc agatgaaagc aattgatgac   2400

aatcaggaaa tgcccccaaa taaaaagaaa aaagagaagg agcgctgtac tgcccttcag   2460

gacaagcttc ttgaagaaga aaagaaacag atggaacatg tacagagagt tctacagaga   2520

ttgaaactgg aaaaggacaa ctggctttta gcaaaatcta ccaaaaatga gaccatcaca   2580

aaatttctac agctgtgtat atttcctcga tgtatttttt cagcaattga tgctgtttac   2640

tgtgctcgtt ttgttgaatt ggtacatcaa cagaaaactc caaatttttc cacacttctt   2700

tgctatgatc gagttttctc tgacataatt tacacagttg caagctgtac tgaaaatgaa   2760

gccagtcgat acggaaggtt tctttgctgc atgttagaga ctgtgaccag gtggcatagt   2820

gatagagcca catatgaaaa ggaatgtgga aactatccag gattccttac catattacgg   2880

gcaactggat ttgatggtgg aaataaggct gatcaattag actatgaaaa ttttcgacat   2940

gttgtacata aatggcatta caaactaacc aaggcatcgg tacattgcct tgaaacaggc   3000

gaatatactc acatcaggaa tatcttgatt gtgctaacaa aaatacttcc ttggtaccca   3060

aaagttttga atctgggtca agctttggaa agaagagtac acaaaatctg ccaagaagaa   3120

aaagagaaga ggccagatct atatgcattg gctatgggct actctgggca gttgaaaagt   3180

agaaagtcat acatgatacc tgaaaatgag tttcatcaca aagacccccc tccgaggaat   3240

gcagttgcca gtgtgcaaaa tgggcctggt ggtgggcctt cttcatcatc aataggaagt   3300

gcatctaaat cggatgaaag cagtactgag gagactgata aatcaaggga gagatctcag   3360

tgtggtgtga aagctgttaa taaagcttct agtaccacac ctaaagggaa ttcaagcaat   3420

ggaaatagtg gctctaacag caacaaagct gttaaagaaa atgacaaaga aaaagggaaa   3480

gagaaagaaa aagagaaaaa agaaaagact ccagctacta ctccagaggc cagggtactt   3540

ggtaaagatg gtaaagaaaa accaaaggaa gagcggccaa ataaagatga aaaagcaaga   3600

gagaccaagg aaagaacgcc gaagtctgac aaagagaaag aaaaattcaa gaaggaagaa   3660

aaagctaaag atgagaaatt taagaccact gtccccaacg cagaatcaaa atcaactcaa   3720

gaaagggaaa gagagaagga gccatccaga gaaagagata tagcaaagga aatgaaatca   3780

aaggaaaatg ttaaaggagg agaaaaaaca ccagtttctg ggtccttgaa atcacctgtt   3840

cccagatcag atattccaga gcctgaaagg gaacaaaaac gccgcaaaat tgatactcac   3900

ccttctccat cacattcctc cacagtaaag gacagtctca tcgaactcaa ggaatcttca   3960

gcaaagctct acattaatca tactcctcca ccactgtcca agagtaagga gagagaaatg   4020

gacaagaaag atttggacaa gtcaagggaa agatccagag aaagagagaa aaaagatgaa   4080

aaggacagga aagagcggaa aagggatcac tcaaacaacg accgtgaagt gccaccggac   4140

ttaaccaaga gacgtaaaga ggagaatgga acaatggggg tttcaaaaca taaaagtgaa   4200

agtccttgtg aatctcctta tccaaatgag aaagacaagg aaaaaaataa gtcaaaatct   4260

tcaggcaaag aaaaaggcag tgattcattt aaatctgaga agatggataa aatctcctcc   4320

ggtggcaaaa aggagtccag gcatgataaa gaaaagatag aaaagaaaga gaaacgggac   4380

agttcaggag gaaaggaaga gaagaaacat cataagtcct cggacaagca cagataatga   4440

agactttcca tc                                                       4452


<210>  4255
<211>  1478
<212>  PRT
<213>  Homosapiens

<400>  4255

Met Phe Val Ser Asp Thr Val Leu Lys Glu Arg Leu Asp Pro Glu Thr 
1               5                   10                  15      


Leu Glu Ser Leu Gly Leu Ile Lys Gln Ser Gln Gln Phe Asn Gln Lys 
            20                  25                  30          


Ser Val Lys Ile Lys Thr Lys Leu Phe Tyr Lys Gln Gln Lys Phe Asn 
        35                  40                  45              


Leu Leu Arg Glu Glu Asn Glu Gly Tyr Ala Lys Leu Ile Ala Glu Leu 
    50                  55                  60                  


Gly Gln Asp Leu Ser Gly Ser Ile Thr Ser Asp Leu Ile Leu Glu Asn 
65                  70                  75                  80  


Ile Lys Ser Leu Ile Gly Cys Phe Asn Leu Asp Pro Asn Arg Val Leu 
                85                  90                  95      


Asp Val Ile Leu Glu Val Phe Glu Cys Arg Pro Glu His Asp Asp Phe 
            100                 105                 110         


Phe Ile Ser Leu Leu Glu Ser Tyr Met Ser Met Cys Glu Pro Gln Thr 
        115                 120                 125             


Leu Cys His Ile Leu Gly Phe Lys Phe Lys Phe Tyr Gln Glu Pro Asn 
    130                 135                 140                 


Gly Glu Thr Pro Ser Ser Leu Tyr Arg Val Ala Ala Val Leu Leu Gln 
145                 150                 155                 160 


Phe Asn Leu Ile Asp Leu Asp Asp Leu Tyr Val His Leu Leu Pro Ala 
                165                 170                 175     


Asp Asn Cys Ile Met Asp Glu His Lys Arg Glu Ile Ala Glu Ala Lys 
            180                 185                 190         


Gln Ile Val Arg Lys Leu Thr Met Val Val Leu Ser Ser Glu Lys Met 
        195                 200                 205             


Asp Glu Arg Glu Lys Glu Lys Glu Lys Glu Glu Glu Lys Val Glu Lys 
    210                 215                 220                 


Pro Pro Asp Asn Gln Lys Leu Gly Leu Leu Glu Ala Leu Leu Lys Ile 
225                 230                 235                 240 


Gly Asp Trp Gln His Ala Gln Asn Ile Met Asp Gln Met Pro Pro Tyr 
                245                 250                 255     


Tyr Ala Ala Ser His Lys Leu Ile Ala Leu Ala Ile Cys Lys Leu Ile 
            260                 265                 270         


His Ile Thr Ile Glu Pro Leu Tyr Arg Arg Val Gly Val Pro Lys Gly 
        275                 280                 285             


Ala Lys Gly Ser Pro Val Asn Ala Leu Gln Asn Lys Arg Ala Pro Lys 
    290                 295                 300                 


Gln Ala Glu Ser Phe Glu Asp Leu Arg Arg Asp Val Phe Asn Met Phe 
305                 310                 315                 320 


Cys Tyr Leu Gly Pro His Leu Ser His Asp Pro Ile Leu Phe Ala Lys 
                325                 330                 335     


Val Val Arg Ile Gly Lys Ser Phe Met Lys Glu Phe Gln Ser Asp Gly 
            340                 345                 350         


Ser Lys Gln Glu Asp Lys Glu Lys Thr Glu Val Ile Leu Ser Cys Leu 
        355                 360                 365             


Leu Ser Ile Thr Asp Gln Val Leu Leu Pro Ser Leu Ser Leu Met Asp 
    370                 375                 380                 


Cys Asn Ala Cys Met Ser Glu Glu Leu Trp Gly Met Phe Lys Thr Phe 
385                 390                 395                 400 


Pro Tyr Gln His Arg Tyr Arg Leu Tyr Gly Gln Trp Lys Asn Glu Thr 
                405                 410                 415     


Tyr Asn Ser His Pro Leu Leu Val Lys Val Lys Ala Gln Thr Ile Asp 
            420                 425                 430         


Arg Ala Lys Tyr Ile Met Lys Arg Leu Thr Lys Glu Asn Val Lys Pro 
        435                 440                 445             


Ser Gly Arg Gln Ile Gly Lys Leu Ser His Ser Asn Pro Thr Ile Leu 
    450                 455                 460                 


Phe Asp Tyr Ile Leu Ser Gln Ile Gln Lys Tyr Asp Asn Leu Ile Thr 
465                 470                 475                 480 


Pro Val Val Asp Ser Leu Lys Tyr Leu Thr Ser Leu Asn Tyr Asp Val 
                485                 490                 495     


Leu Ala Tyr Cys Ile Ile Glu Ala Leu Ala Asn Pro Glu Lys Glu Arg 
            500                 505                 510         


Met Lys His Asp Asp Thr Thr Ile Ser Ser Trp Leu Gln Ser Leu Ala 
        515                 520                 525             


Ser Phe Cys Gly Ala Val Phe Arg Lys Tyr Pro Ile Asp Leu Ala Gly 
    530                 535                 540                 


Leu Leu Gln Tyr Val Ala Asn Gln Leu Lys Ala Gly Lys Ser Phe Asp 
545                 550                 555                 560 


Leu Leu Ile Leu Lys Glu Val Val Gln Lys Met Ala Gly Ile Glu Ile 
                565                 570                 575     


Thr Glu Glu Met Thr Met Glu Gln Leu Glu Ala Met Thr Gly Gly Glu 
            580                 585                 590         


Gln Leu Lys Ala Glu Gly Gly Tyr Phe Gly Gln Ile Arg Asn Thr Lys 
        595                 600                 605             


Lys Ser Ser Gln Arg Leu Lys Asp Ala Leu Leu Asp His Asp Leu Ala 
    610                 615                 620                 


Leu Pro Leu Cys Leu Leu Met Ala Gln Gln Arg Asn Gly Val Ile Phe 
625                 630                 635                 640 


Gln Glu Gly Gly Glu Lys His Leu Lys Leu Val Gly Lys Leu Tyr Asp 
                645                 650                 655     


Gln Cys His Asp Thr Leu Val Gln Phe Gly Gly Phe Leu Ala Ser Asn 
            660                 665                 670         


Leu Ser Thr Glu Asp Tyr Ile Lys Arg Val Pro Ser Ile Asp Val Leu 
        675                 680                 685             


Cys Asn Glu Phe His Thr Pro His Asp Ala Ala Phe Phe Leu Ser Arg 
    690                 695                 700                 


Pro Met Tyr Ala His His Ile Ser Ser Lys Tyr Asp Glu Leu Lys Lys 
705                 710                 715                 720 


Ser Glu Lys Gly Ser Lys Gln Gln His Lys Val His Lys Tyr Ile Thr 
                725                 730                 735     


Ser Cys Glu Met Val Met Ala Pro Val His Glu Ala Val Val Ser Leu 
            740                 745                 750         


His Val Ser Lys Val Trp Asp Asp Ile Ser Pro Gln Phe Tyr Ala Thr 
        755                 760                 765             


Phe Trp Ser Leu Thr Met Tyr Asp Leu Ala Val Pro His Thr Ser Tyr 
    770                 775                 780                 


Glu Arg Glu Val Asn Lys Leu Lys Val Gln Met Lys Ala Ile Asp Asp 
785                 790                 795                 800 


Asn Gln Glu Met Pro Pro Asn Lys Lys Lys Lys Glu Lys Glu Arg Cys 
                805                 810                 815     


Thr Ala Leu Gln Asp Lys Leu Leu Glu Glu Glu Lys Lys Gln Met Glu 
            820                 825                 830         


His Val Gln Arg Val Leu Gln Arg Leu Lys Leu Glu Lys Asp Asn Trp 
        835                 840                 845             


Leu Leu Ala Lys Ser Thr Lys Asn Glu Thr Ile Thr Lys Phe Leu Gln 
    850                 855                 860                 


Leu Cys Ile Phe Pro Arg Cys Ile Phe Ser Ala Ile Asp Ala Val Tyr 
865                 870                 875                 880 


Cys Ala Arg Phe Val Glu Leu Val His Gln Gln Lys Thr Pro Asn Phe 
                885                 890                 895     


Ser Thr Leu Leu Cys Tyr Asp Arg Val Phe Ser Asp Ile Ile Tyr Thr 
            900                 905                 910         


Val Ala Ser Cys Thr Glu Asn Glu Ala Ser Arg Tyr Gly Arg Phe Leu 
        915                 920                 925             


Cys Cys Met Leu Glu Thr Val Thr Arg Trp His Ser Asp Arg Ala Thr 
    930                 935                 940                 


Tyr Glu Lys Glu Cys Gly Asn Tyr Pro Gly Phe Leu Thr Ile Leu Arg 
945                 950                 955                 960 


Ala Thr Gly Phe Asp Gly Gly Asn Lys Ala Asp Gln Leu Asp Tyr Glu 
                965                 970                 975     


Asn Phe Arg His Val Val His Lys Trp His Tyr Lys Leu Thr Lys Ala 
            980                 985                 990         


Ser Val His Cys Leu Glu Thr Gly  Glu Tyr Thr His Ile  Arg Asn Ile 
        995                 1000                 1005             


Leu Ile  Val Leu Thr Lys Ile  Leu Pro Trp Tyr Pro  Lys Val Leu 
    1010                 1015                 1020             


Asn Leu  Gly Gln Ala Leu Glu  Arg Arg Val His Lys  Ile Cys Gln 
    1025                 1030                 1035             


Glu Glu  Lys Glu Lys Arg Pro  Asp Leu Tyr Ala Leu  Ala Met Gly 
    1040                 1045                 1050             


Tyr Ser  Gly Gln Leu Lys Ser  Arg Lys Ser Tyr Met  Ile Pro Glu 
    1055                 1060                 1065             


Asn Glu  Phe His His Lys Asp  Pro Pro Pro Arg Asn  Ala Val Ala 
    1070                 1075                 1080             


Ser Val  Gln Asn Gly Pro Gly  Gly Gly Pro Ser Ser  Ser Ser Ile 
    1085                 1090                 1095             


Gly Ser  Ala Ser Lys Ser Asp  Glu Ser Ser Thr Glu  Glu Thr Asp 
    1100                 1105                 1110             


Lys Ser  Arg Glu Arg Ser Gln  Cys Gly Val Lys Ala  Val Asn Lys 
    1115                 1120                 1125             


Ala Ser  Ser Thr Thr Pro Lys  Gly Asn Ser Ser Asn  Gly Asn Ser 
    1130                 1135                 1140             


Gly Ser  Asn Ser Asn Lys Ala  Val Lys Glu Asn Asp  Lys Glu Lys 
    1145                 1150                 1155             


Gly Lys  Glu Lys Glu Lys Glu  Lys Lys Glu Lys Thr  Pro Ala Thr 
    1160                 1165                 1170             


Thr Pro  Glu Ala Arg Val Leu  Gly Lys Asp Gly Lys  Glu Lys Pro 
    1175                 1180                 1185             


Lys Glu  Glu Arg Pro Asn Lys  Asp Glu Lys Ala Arg  Glu Thr Lys 
    1190                 1195                 1200             


Glu Arg  Thr Pro Lys Ser Asp  Lys Glu Lys Glu Lys  Phe Lys Lys 
    1205                 1210                 1215             


Glu Glu  Lys Ala Lys Asp Glu  Lys Phe Lys Thr Thr  Val Pro Asn 
    1220                 1225                 1230             


Ala Glu  Ser Lys Ser Thr Gln  Glu Arg Glu Arg Glu  Lys Glu Pro 
    1235                 1240                 1245             


Ser Arg  Glu Arg Asp Ile Ala  Lys Glu Met Lys Ser  Lys Glu Asn 
    1250                 1255                 1260             


Val Lys  Gly Gly Glu Lys Thr  Pro Val Ser Gly Ser  Leu Lys Ser 
    1265                 1270                 1275             


Pro Val  Pro Arg Ser Asp Ile  Pro Glu Pro Glu Arg  Glu Gln Lys 
    1280                 1285                 1290             


Arg Arg  Lys Ile Asp Thr His  Pro Ser Pro Ser His  Ser Ser Thr 
    1295                 1300                 1305             


Val Lys  Asp Ser Leu Ile Glu  Leu Lys Glu Ser Ser  Ala Lys Leu 
    1310                 1315                 1320             


Tyr Ile  Asn His Thr Pro Pro  Pro Leu Ser Lys Ser  Lys Glu Arg 
    1325                 1330                 1335             


Glu Met  Asp Lys Lys Asp Leu  Asp Lys Ser Arg Glu  Arg Ser Arg 
    1340                 1345                 1350             


Glu Arg  Glu Lys Lys Asp Glu  Lys Asp Arg Lys Glu  Arg Lys Arg 
    1355                 1360                 1365             


Asp His  Ser Asn Asn Asp Arg  Glu Val Pro Pro Asp  Leu Thr Lys 
    1370                 1375                 1380             


Arg Arg  Lys Glu Glu Asn Gly  Thr Met Gly Val Ser  Lys His Lys 
    1385                 1390                 1395             


Ser Glu  Ser Pro Cys Glu Ser  Pro Tyr Pro Asn Glu  Lys Asp Lys 
    1400                 1405                 1410             


Glu Lys  Asn Lys Ser Lys Ser  Ser Gly Lys Glu Lys  Gly Ser Asp 
    1415                 1420                 1425             


Ser Phe  Lys Ser Glu Lys Met  Asp Lys Ile Ser Ser  Gly Gly Lys 
    1430                 1435                 1440             


Lys Glu  Ser Arg His Asp Lys  Glu Lys Ile Glu Lys  Lys Glu Lys 
    1445                 1450                 1455             


Arg Asp  Ser Ser Gly Gly Lys  Glu Glu Lys Lys His  His Lys Ser 
    1460                 1465                 1470             


Ser Asp  Lys His Arg 
    1475             


<210>  4256
<211>  2021
<212>  DNA
<213>  Homosapiens

<400>  4256
gctttcccga cggccatctt gggaatctga cggatcggag gcatttgtga ggaggcgcga     60

atcaagttag cggggggaag agtcttagac ctggccagtc ctcagggtga gggccctgag    120

gaagaactga gggacctccc accatagaga gaagaaaccc cggcctgtac tgcgctgccg    180

tgagactggt gctccaggaa ccaggtggtg acgaactggg tgtgaggcac acagcctaaa    240

gtcagcacag cagaggaggc ccaggcagtg ccaggagtca aggcctgttg gatctcatca    300

tccatatccc tgttgatacg tttacctgct gctcctgaag aagtcgtcat gcctcccgtt    360

ccaggcgttc cattccgcaa cgttgacaac gactccccga cctcagttga gttagaagac    420

tgggtagatg cacagcatcc cacagatgag gaagaggagg aagcctcctc cgcctcttcc    480

actttgtact tagtattttc cccctcttct ttctccacat cctcttctct gattcttggt    540

ggtcctgagg aggaggaggt gccctctggt gtgataccaa atcttaccga gagcattccc    600

agtagtcctc cacagggtcc tccacagggt ccttcccaga gtcctctgag ctcctgctgc    660

tcctcttttt catggagctc attcagtgag gagtccagca gccagaaagg ggaggataca    720

ggcacctgtc agggcctgcc agacagtgag tcctctttca catatacact agatgaaaag    780

gtggccgagt tagtggagtt cctgctcctc aaatacgaag cagaggagcc tgtaacagag    840

gcagagatgc tgatgattgt catcaagtac aaagattact ttcctgtgat actcaagaga    900

gcccgtgagt tcatggagct tctttttggc cttgccctga tagaagtggg ccctgaccac    960

ttctgtgtgt ttgcaaacac agtaggcctc accgatgagg gtagtgatga tgagggcatg   1020

cccgagaaca gcctcctgat tattattctg agtgtgatct tcataaaggg caactgtgcc   1080

tctgaggagg tcatctggga agtgctgaat gcagtagggg tatatgctgg gagggagcac   1140

ttcgtctatg gggagcctag ggagctcctc actaaagttt gggtgcaggg acattacctg   1200

gagtatcggg aggtgcccca cagttctcct ccatattatg aattcctgtg gggtccaaga   1260

gcccattcag aaagcatcaa gaagaaagta ctagagtttt tagccaagct gaacaacact   1320

gttcctagtt cctttccatc ctggtacaag gatgctttga aagatgtgga agagagagtc   1380

caggccacaa ttgataccgc agatgatgcc actgtcatgg ccagtgaaag cctcagtgtc   1440

atgtccagca acgtctcctt ttctgagtga agtctaggat agtttcttcc ccttgtgttt   1500

gaacagggca gtttaggttc taggtagtgg agggccaggt ggggctcgag gaacgtagtg   1560

ttctttgcat ttctgtccca tatgggtgat gtagagattt acctgttttt cagtattttc   1620

taaatgcttt tcctttgaat agcaggtagt tagcttcaga gtgttaattt atgaatatta   1680

gtcgcacatg tattgctctt tatctggttt aagagtaaca gtttgatatt ttgttaaaaa   1740

aatggaaata ccttctccct tattttgtga tctgtaacag ggtagtgtgg tattgtaata   1800

ggcatttttt ttttttttta caatgtgcaa taactcagca gttaaatagt ggaacaaaat   1860

tgaagggtgg tcagtagttt catttccttg tcctgcttat tcttttgttc ttgaaaatta   1920

tatatacctg gctttgctta gcttgttgaa gaaagtagca gaaattaaat cttaataaaa   1980

gaaagcccca ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       2021


<210>  4257
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  4257

Met Pro Pro Val Pro Gly Val Pro Phe Arg Asn Val Asp Asn Asp Ser 
1               5                   10                  15      


Pro Thr Ser Val Glu Leu Glu Asp Trp Val Asp Ala Gln His Pro Thr 
            20                  25                  30          


Asp Glu Glu Glu Glu Glu Ala Ser Ser Ala Ser Ser Thr Leu Tyr Leu 
        35                  40                  45              


Val Phe Ser Pro Ser Ser Phe Ser Thr Ser Ser Ser Leu Ile Leu Gly 
    50                  55                  60                  


Gly Pro Glu Glu Glu Glu Val Pro Ser Gly Val Ile Pro Asn Leu Thr 
65                  70                  75                  80  


Glu Ser Ile Pro Ser Ser Pro Pro Gln Gly Pro Pro Gln Gly Pro Ser 
                85                  90                  95      


Gln Ser Pro Leu Ser Ser Cys Cys Ser Ser Phe Ser Trp Ser Ser Phe 
            100                 105                 110         


Ser Glu Glu Ser Ser Ser Gln Lys Gly Glu Asp Thr Gly Thr Cys Gln 
        115                 120                 125             


Gly Leu Pro Asp Ser Glu Ser Ser Phe Thr Tyr Thr Leu Asp Glu Lys 
    130                 135                 140                 


Val Ala Glu Leu Val Glu Phe Leu Leu Leu Lys Tyr Glu Ala Glu Glu 
145                 150                 155                 160 


Pro Val Thr Glu Ala Glu Met Leu Met Ile Val Ile Lys Tyr Lys Asp 
                165                 170                 175     


Tyr Phe Pro Val Ile Leu Lys Arg Ala Arg Glu Phe Met Glu Leu Leu 
            180                 185                 190         


Phe Gly Leu Ala Leu Ile Glu Val Gly Pro Asp His Phe Cys Val Phe 
        195                 200                 205             


Ala Asn Thr Val Gly Leu Thr Asp Glu Gly Ser Asp Asp Glu Gly Met 
    210                 215                 220                 


Pro Glu Asn Ser Leu Leu Ile Ile Ile Leu Ser Val Ile Phe Ile Lys 
225                 230                 235                 240 


Gly Asn Cys Ala Ser Glu Glu Val Ile Trp Glu Val Leu Asn Ala Val 
                245                 250                 255     


Gly Val Tyr Ala Gly Arg Glu His Phe Val Tyr Gly Glu Pro Arg Glu 
            260                 265                 270         


Leu Leu Thr Lys Val Trp Val Gln Gly His Tyr Leu Glu Tyr Arg Glu 
        275                 280                 285             


Val Pro His Ser Ser Pro Pro Tyr Tyr Glu Phe Leu Trp Gly Pro Arg 
    290                 295                 300                 


Ala His Ser Glu Ser Ile Lys Lys Lys Val Leu Glu Phe Leu Ala Lys 
305                 310                 315                 320 


Leu Asn Asn Thr Val Pro Ser Ser Phe Pro Ser Trp Tyr Lys Asp Ala 
                325                 330                 335     


Leu Lys Asp Val Glu Glu Arg Val Gln Ala Thr Ile Asp Thr Ala Asp 
            340                 345                 350         


Asp Ala Thr Val Met Ala Ser Glu Ser Leu Ser Val Met Ser Ser Asn 
        355                 360                 365             


Val Ser Phe Ser Glu 
    370             


<210>  4258
<211>  585
<212>  DNA
<213>  Homosapiens

<400>  4258
ctctctcatc cccttgggat tcaaagctga gaagatgtaa ggactggagc tgcagcagtc     60

tttctgggac cattatacag agattctgtc tgaggttgga tccacgtggt caaaagtatt    120

gctgaggagc cagagagaga ctgaggtctg atgacatcac ttgagccctg cagacttttc    180

atttacggga aaacagagag gatgaaggcc tatctaaaga gcgcagaagg cttttttgtc    240

ctaaataaaa gtaccacaat tggaaggcat gaaaattcag accttgtttt acagtctcct    300

gacatcgaca accaccatgc actcattgaa tataacgagg cggagtgcag ctttgttctc    360

caggacttca attcccgcaa cggcacgttt gtcaacgagt gccacattca aaacgtggct    420

gtgaagctca tccctggaga catcctgaga tttgggtctg cagggctgac ctatgaactg    480

gtcattgaaa atccacctcc ggtgaccttc ccatggacag aaaacctccc aagacctccc    540

aactaccagg tggatgcctt tgcaaataac ttacccatgg agtga                    585


<210>  4259
<211>  144
<212>  PRT
<213>  Homosapiens

<400>  4259

Met Thr Ser Leu Glu Pro Cys Arg Leu Phe Ile Tyr Gly Lys Thr Glu 
1               5                   10                  15      


Arg Met Lys Ala Tyr Leu Lys Ser Ala Glu Gly Phe Phe Val Leu Asn 
            20                  25                  30          


Lys Ser Thr Thr Ile Gly Arg His Glu Asn Ser Asp Leu Val Leu Gln 
        35                  40                  45              


Ser Pro Asp Ile Asp Asn His His Ala Leu Ile Glu Tyr Asn Glu Ala 
    50                  55                  60                  


Glu Cys Ser Phe Val Leu Gln Asp Phe Asn Ser Arg Asn Gly Thr Phe 
65                  70                  75                  80  


Val Asn Glu Cys His Ile Gln Asn Val Ala Val Lys Leu Ile Pro Gly 
                85                  90                  95      


Asp Ile Leu Arg Phe Gly Ser Ala Gly Leu Thr Tyr Glu Leu Val Ile 
            100                 105                 110         


Glu Asn Pro Pro Pro Val Thr Phe Pro Trp Thr Glu Asn Leu Pro Arg 
        115                 120                 125             


Pro Pro Asn Tyr Gln Val Asp Ala Phe Ala Asn Asn Leu Pro Met Glu 
    130                 135                 140                 


<210>  4260
<211>  732
<212>  DNA
<213>  Homosapiens

<400>  4260
aaaaaaagaa gtcacttagc tcttcgctgg ttgtcacacg tccggaggcc gagccgtcgc     60

gtacctagga tacctggaag ccgaagccac acctcccgca tggcccctcc ggccagccgg    120

gcccctcaga tgagagctgc acccaggcca gcaccagtcg ctcagccacc agcagcggca    180

ccgccatcta cagttggctc ttctgctgct gcgccccggc agccaggtct gatggcccag    240

atggcaacca ctgcagctgg cgtggctgtg ggctctgctg tggggcacat actgggtcat    300

gccattactg ggggcttcag tggaggaagt aatgctgagc ctgcgaggcc tgacatcact    360

taccaggagc ctcagggaac ccagccggca cagcagcagc agccttgctt ctgtgagatc    420

aaacagtttc tggagtgtgc cgagaaccag ggtgacatca agctctgtga gggtttcaat    480

gaggtgctga aacagtgccg acttgcaaac ggattggcct aatcaagaag ttcaacctgg    540

agagatggaa aatcagctct catactaatt aatttagtat aaaaatagaa ttggtagtga    600

gggtataaag tgtaagcatc agttaaactt ctcctgtcat tcctagcttc cttgcttcag    660

aattgaaatg gaagggaggg tgttcctact ctgtagaatc tgggactggg caaatgtttg    720

tgtgccactg ca                                                        732


<210>  4261
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  4261

Met Ala Pro Pro Ala Ser Arg Ala Pro Gln Met Arg Ala Ala Pro Arg 
1               5                   10                  15      


Pro Ala Pro Val Ala Gln Pro Pro Ala Ala Ala Pro Pro Ser Thr Val 
            20                  25                  30          


Gly Ser Ser Ala Ala Ala Pro Arg Gln Pro Gly Leu Met Ala Gln Met 
        35                  40                  45              


Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Ile 
    50                  55                  60                  


Leu Gly His Ala Ile Thr Gly Gly Phe Ser Gly Gly Ser Asn Ala Glu 
65                  70                  75                  80  


Pro Ala Arg Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Pro 
                85                  90                  95      


Ala Gln Gln Gln Gln Pro Cys Phe Cys Glu Ile Lys Gln Phe Leu Glu 
            100                 105                 110         


Cys Ala Glu Asn Gln Gly Asp Ile Lys Leu Cys Glu Gly Phe Asn Glu 
        115                 120                 125             


Val Leu Lys Gln Cys Arg Leu Ala Asn Gly Leu Ala 
    130                 135                 140 


<210>  4262
<211>  1490
<212>  DNA
<213>  Homosapiens

<400>  4262
cataggcgag gcattcctgg ggtttgcgcc gtatcctttt acaaagtcct ggctttggct     60

ggtgcgacca aagaaaggaa accggcgctt gagacttgtc tgggctggct atggtgaagc    120

agtgaaacgg tgcagaattg tgtcaatgag gctagttcag ttgtgcaaga gcatttcctc    180

aaagtaagac agaagctttt agttacgtca acacctgcta atgttaggct ggccagaaat    240

ttcctgacaa ataatgggtg aaggtcgggc gtgtggtcgc tcatgcctgt aatctcagcg    300

ctttgggatc acttgaggtc aggagttcga gaccagcttg gccaactagg cgaaacccca    360

tctctactga aagtacaaaa attagccgtg tgtggtggcg cgcatctgta atcccagcta    420

ctctggaggc tgaggcagga caatcgcttg aacccaggag gcagaggttg cagtgagctg    480

agatcacgcc acttaaaaga aacgaaactt tgctggtgac catgtggtga tgaaactgag    540

cgttttggag cgcagcaagg tgactcccca tgtaattagt atagacagag agtttgtgct    600

ctaaaggtta gaaataaatg ttttcggcct ggtggctcat gcctgtaatc ccaggacttt    660

gaaaggctga gccaggcgga tcacctgagg tcagggttcg agaccagcct ggccaacatg    720

gtgaaacccg tctctattaa agatacaaaa attagccagg cggaagaagt cacttagctc    780

ttcgctggtt gtcacacgtc cggaggccga gccgtcgcgt acctaggata cctggaagcc    840

gaagccacac ctcccgcatg gcccctccgg ccagccgggc ccctcagatg agagctgcac    900

ccaggccagc accagtcgct cagccaccag cagcggcacc gccatctaca gttggctctt    960

ctgctgctgc gccccggcag ccaggtctga tggcccagat ggcaaccact gcagctggcg   1020

tggctgtggg ctctgctgtg gggcacatac tgggtcatgc cattactggg ggcttcagtg   1080

gaggaagtaa tgctgagcct gcgaggcctg acatcactta ccaggagcct cagggaaccc   1140

agccggcaca gcagcagcag ccttgcttct gtgagatcaa acagtttctg gagtgtgccg   1200

agaaccaggg tgacatcaag ctctgtgagg gtttcaatga ggtgctgaaa cagtgccgac   1260

ttgcaaacgg attggcctaa tcaagaagtt caacctggag agatggaaaa tcagctctca   1320

tactaattaa tttagtataa aaatagaatt ggtagtgagg gtataaagtg taagcatcag   1380

ttaaacttct cctgtcattc ctagcttcct tgcttcagaa ttgaaatgga agggagggtg   1440

ttcctactct gtagaatctg ggactgggca aatgtttgtg tgccactgca              1490


<210>  4263
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  4263

Met Ala Pro Pro Ala Ser Arg Ala Pro Gln Met Arg Ala Ala Pro Arg 
1               5                   10                  15      


Pro Ala Pro Val Ala Gln Pro Pro Ala Ala Ala Pro Pro Ser Thr Val 
            20                  25                  30          


Gly Ser Ser Ala Ala Ala Pro Arg Gln Pro Gly Leu Met Ala Gln Met 
        35                  40                  45              


Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Ile 
    50                  55                  60                  


Leu Gly His Ala Ile Thr Gly Gly Phe Ser Gly Gly Ser Asn Ala Glu 
65                  70                  75                  80  


Pro Ala Arg Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Pro 
                85                  90                  95      


Ala Gln Gln Gln Gln Pro Cys Phe Cys Glu Ile Lys Gln Phe Leu Glu 
            100                 105                 110         


Cys Ala Glu Asn Gln Gly Asp Ile Lys Leu Cys Glu Gly Phe Asn Glu 
        115                 120                 125             


Val Leu Lys Gln Cys Arg Leu Ala Asn Gly Leu Ala 
    130                 135                 140 


<210>  4264
<211>  1562
<212>  DNA
<213>  Homosapiens

<400>  4264
cataggcgag gcattcctgg ggtttgcgcc gtatcctttt acaaagtcct ggctttggct     60

ggtgcgacca aagaaaggaa accggcgctt gagacttgtc tgggctggct atggtgaagc    120

agtgaaacgg tgcagaattg tgtcaatgag gctagttcag ttgtgcaaga gcatttcctc    180

aaagtaagac agaagctttt agttacgtca acacctgcta atgttaggct ggccagaaat    240

ttcctgacaa ataatgggtg aaggtcgggc gtgtggtcgc tcatgcctgt aatctcagcg    300

ctttgggatc acttgaggtc aggagttcga gaccagcttg gccaactagg cgaaacccca    360

tctctactga aagtacaaaa attagccgtg tgtggtggcg cgcatctgta atcccagcta    420

ctctggaggc tgaggcagga caatcgcttg aacccaggag gcagaggttg cagtgagctg    480

agatcacgcc acttaaaaga aacgaaactt tgctggtgac catgtggtga tgaaactgag    540

cgttttggag cgcagcaagg tgactcccca tgtaattagt atagacagag agtttgtgct    600

ctaaaggtta gaaataaatg ttttcggcct ggtggctcat gcctgtaatc ccaggacttt    660

gaaaggctga gccaggcgga tcacctgagg tcagggttcg agaccagcct ggccaacatg    720

gtgaaacccg tctctattaa agatacaaaa attagccagg cggaagaagt cacttagctc    780

ttcgctggtt gtcacacgtc cggaggccga gccgtcgcgt acctaggata cctggaagcc    840

gaagccacac ctcccgcatg gcccctccgg ccagccgggc ccctcagatg agagctgcac    900

ccaggccagc accagtcgct cagccaccag cagcggcacc gccatctaca gttggctctt    960

ctgctgctgc gccccggcag ccaggtctga tggcccagat ggcaaccact gcagctggcg   1020

tggctgtggg ctctgctgtg gggcacatac tgggtcatgc cattactggg ggcttcagtg   1080

gaggaagtaa tgctgagcct gcgaggcctg acatcactta ccaggagcct cagggaaccc   1140

agccggcaca gcagcagcag ccttgcttct gtgagatcaa acagtttctg gagtgtgccg   1200

agaaccaggg tgacatcaag ctctgtgagg gtttcaatga ggtgctgaaa cagtgccgac   1260

ttgcaaacgg attggcctaa tcaagaagtt caacctggag agatggaaaa tcagctctca   1320

tactaattaa tttagtataa aaatagaatt ggtagtgagg gtataaagtg taagcatcag   1380

ttaaacttct cctgtcattc ctagcttcct tgcttcagaa ttgaaatgga agggagggtg   1440

ttcctactct gtagaatctg ggactgggca aatgtttgtg tggcctcctt aaactagctg   1500

ttatgatttt attctttgtg agttaattag aataaagtca ttttcttcca aaaaagaaaa   1560

aa                                                                  1562


<210>  4265
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  4265

Met Ala Pro Pro Ala Ser Arg Ala Pro Gln Met Arg Ala Ala Pro Arg 
1               5                   10                  15      


Pro Ala Pro Val Ala Gln Pro Pro Ala Ala Ala Pro Pro Ser Thr Val 
            20                  25                  30          


Gly Ser Ser Ala Ala Ala Pro Arg Gln Pro Gly Leu Met Ala Gln Met 
        35                  40                  45              


Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Ile 
    50                  55                  60                  


Leu Gly His Ala Ile Thr Gly Gly Phe Ser Gly Gly Ser Asn Ala Glu 
65                  70                  75                  80  


Pro Ala Arg Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Pro 
                85                  90                  95      


Ala Gln Gln Gln Gln Pro Cys Phe Cys Glu Ile Lys Gln Phe Leu Glu 
            100                 105                 110         


Cys Ala Glu Asn Gln Gly Asp Ile Lys Leu Cys Glu Gly Phe Asn Glu 
        115                 120                 125             


Val Leu Lys Gln Cys Arg Leu Ala Asn Gly Leu Ala 
    130                 135                 140 


<210>  4266
<211>  804
<212>  DNA
<213>  Homosapiens

<400>  4266
aaaaaaagaa gtcacttagc tcttcgctgg ttgtcacacg tccggaggcc gagccgtcgc     60

gtacctagga tacctggaag ccgaagccac acctcccgca tggcccctcc ggccagccgg    120

gcccctcaga tgagagctgc acccaggcca gcaccagtcg ctcagccacc agcagcggca    180

ccgccatcta cagttggctc ttctgctgct gcgccccggc agccaggtct gatggcccag    240

atggcaacca ctgcagctgg cgtggctgtg ggctctgctg tggggcacat actgggtcat    300

gccattactg ggggcttcag tggaggaagt aatgctgagc ctgcgaggcc tgacatcact    360

taccaggagc ctcagggaac ccagccggca cagcagcagc agccttgctt ctgtgagatc    420

aaacagtttc tggagtgtgc cgagaaccag ggtgacatca agctctgtga gggtttcaat    480

gaggtgctga aacagtgccg acttgcaaac ggattggcct aatcaagaag ttcaacctgg    540

agagatggaa aatcagctct catactaatt aatttagtat aaaaatagaa ttggtagtga    600

gggtataaag tgtaagcatc agttaaactt ctcctgtcat tcctagcttc cttgcttcag    660

aattgaaatg gaagggaggg tgttcctact ctgtagaatc tgggactggg caaatgtttg    720

tgtggcctcc ttaaactagc tgttatgatt ttattctttg tgagttaatt agaataaagt    780

cattttcttc caaaaaagaa aaaa                                           804


<210>  4267
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  4267

Met Ala Pro Pro Ala Ser Arg Ala Pro Gln Met Arg Ala Ala Pro Arg 
1               5                   10                  15      


Pro Ala Pro Val Ala Gln Pro Pro Ala Ala Ala Pro Pro Ser Thr Val 
            20                  25                  30          


Gly Ser Ser Ala Ala Ala Pro Arg Gln Pro Gly Leu Met Ala Gln Met 
        35                  40                  45              


Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Ile 
    50                  55                  60                  


Leu Gly His Ala Ile Thr Gly Gly Phe Ser Gly Gly Ser Asn Ala Glu 
65                  70                  75                  80  


Pro Ala Arg Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Pro 
                85                  90                  95      


Ala Gln Gln Gln Gln Pro Cys Phe Cys Glu Ile Lys Gln Phe Leu Glu 
            100                 105                 110         


Cys Ala Glu Asn Gln Gly Asp Ile Lys Leu Cys Glu Gly Phe Asn Glu 
        115                 120                 125             


Val Leu Lys Gln Cys Arg Leu Ala Asn Gly Leu Ala 
    130                 135                 140 


<210>  4268
<211>  802
<212>  DNA
<213>  Homosapiens

<400>  4268
aaaaaaaagt cacttagctc ttcgctggtt gtcacacgtc cggaggccga gccgtcgcgt     60

acctaggata cctggaagcc gaagccacac ctcccgcatg gcccctccgg ccagccgggc    120

ccctcagatg agagctgcac ccaggccagc accagtcgct cagccaccag cagcggcacc    180

gccatctaca gttggctctt ctgctgctgc gccccggcag ccaggtctga tggcccagat    240

ggcaaccact gcagctggcg tggctgtggg ctctgctgtg gggcacatac tgggtcatgc    300

cattactggg ggcttcagtg gaggaagtaa tgctgagcct gcgaggcctg acatcactta    360

ccaggagcct cagggaaccc agccggcaca gcagcagcag ccttgcttct gtgagatcaa    420

acagtttctg gagtgtgccg agaaccaggg tgacatcaag ctctgtgagg gtttcaatga    480

ggtgctgaaa cagtgccgac ttgcaaacgg attggcctaa tcaagaagtt caacctggag    540

agatggaaaa tcagctctca tactaattaa tttagtataa aaatagaatt ggtagtgagg    600

gtataaagtg taagcatcag ttaaacttct cctgtcattc ctagcttcct tgcttcagaa    660

ttgaaatgga agggagggtg ttcctactct gtagaatctg ggactgggca aatgtttgtg    720

tggcctcctt aaactagctg ttatgatttt attctttgtg agttaattag aataaagtca    780

ttttcttcca aaaaagaaaa aa                                             802


<210>  4269
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  4269

Met Ala Pro Pro Ala Ser Arg Ala Pro Gln Met Arg Ala Ala Pro Arg 
1               5                   10                  15      


Pro Ala Pro Val Ala Gln Pro Pro Ala Ala Ala Pro Pro Ser Thr Val 
            20                  25                  30          


Gly Ser Ser Ala Ala Ala Pro Arg Gln Pro Gly Leu Met Ala Gln Met 
        35                  40                  45              


Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Ile 
    50                  55                  60                  


Leu Gly His Ala Ile Thr Gly Gly Phe Ser Gly Gly Ser Asn Ala Glu 
65                  70                  75                  80  


Pro Ala Arg Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Pro 
                85                  90                  95      


Ala Gln Gln Gln Gln Pro Cys Phe Cys Glu Ile Lys Gln Phe Leu Glu 
            100                 105                 110         


Cys Ala Glu Asn Gln Gly Asp Ile Lys Leu Cys Glu Gly Phe Asn Glu 
        115                 120                 125             


Val Leu Lys Gln Cys Arg Leu Ala Asn Gly Leu Ala 
    130                 135                 140 


<210>  4270
<211>  732
<212>  DNA
<213>  Homosapiens

<400>  4270
aaaaaaagaa gtcacttagc tcttcgctgg ttgtcacacg tccggaggcc gagccgtcgc     60

gtacctagga tacctggaag ccgaagccac acctcccgca tggcccctcc ggccagccgg    120

gcccctcaga tgagagctgc acccaggcca gcaccagtcg ctcagccacc agcagcggca    180

ccgccatcta cagttggctc ttctgctgct gcgccccggc agccaggtct gatggcccag    240

atggcaacca ctgcagctgg cgtggctgtg ggctctgctg tggggcacat actgggtcat    300

gccattactg ggggcttcag tggaggaagt aatgctgagc ctgcgaggcc tgacatcact    360

taccaggagc ctcagggaac ccagccggca cagcagcagc agccttgctt ctgtgagatc    420

aaacagtttc tggagtgtgc cgagaaccag ggtgacatca agctctgtga gggtttcaat    480

gaggtgctga aacagtgccg acttgcaaac ggattggcct aatcaagaag ttcaacctgg    540

agagatggaa aatcagctct catactaatt aatttagtat aaaaatagaa ttggtagtga    600

gggtataaag tgtaagcatc agttaaactt ctcctgtcat tcctagcttc cttgcttcag    660

aattgaaatg gaagggaggg tgttcctact ctgtagaatc tgggactggg caaatgtttg    720

tgtgccactg ca                                                        732


<210>  4271
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  4271

Met Ala Pro Pro Ala Ser Arg Ala Pro Gln Met Arg Ala Ala Pro Arg 
1               5                   10                  15      


Pro Ala Pro Val Ala Gln Pro Pro Ala Ala Ala Pro Pro Ser Thr Val 
            20                  25                  30          


Gly Ser Ser Ala Ala Ala Pro Arg Gln Pro Gly Leu Met Ala Gln Met 
        35                  40                  45              


Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Ile 
    50                  55                  60                  


Leu Gly His Ala Ile Thr Gly Gly Phe Ser Gly Gly Ser Asn Ala Glu 
65                  70                  75                  80  


Pro Ala Arg Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Pro 
                85                  90                  95      


Ala Gln Gln Gln Gln Pro Cys Phe Cys Glu Ile Lys Gln Phe Leu Glu 
            100                 105                 110         


Cys Ala Glu Asn Gln Gly Asp Ile Lys Leu Cys Glu Gly Phe Asn Glu 
        115                 120                 125             


Val Leu Lys Gln Cys Arg Leu Ala Asn Gly Leu Ala 
    130                 135                 140 


<210>  4272
<211>  1490
<212>  DNA
<213>  Homosapiens

<400>  4272
cataggcgag gcattcctgg ggtttgcgcc gtatcctttt acaaagtcct ggctttggct     60

ggtgcgacca aagaaaggaa accggcgctt gagacttgtc tgggctggct atggtgaagc    120

agtgaaacgg tgcagaattg tgtcaatgag gctagttcag ttgtgcaaga gcatttcctc    180

aaagtaagac agaagctttt agttacgtca acacctgcta atgttaggct ggccagaaat    240

ttcctgacaa ataatgggtg aaggtcgggc gtgtggtcgc tcatgcctgt aatctcagcg    300

ctttgggatc acttgaggtc aggagttcga gaccagcttg gccaactagg cgaaacccca    360

tctctactga aagtacaaaa attagccgtg tgtggtggcg cgcatctgta atcccagcta    420

ctctggaggc tgaggcagga caatcgcttg aacccaggag gcagaggttg cagtgagctg    480

agatcacgcc acttaaaaga aacgaaactt tgctggtgac catgtggtga tgaaactgag    540

cgttttggag cgcagcaagg tgactcccca tgtaattagt atagacagag agtttgtgct    600

ctaaaggtta gaaataaatg ttttcggcct ggtggctcat gcctgtaatc ccaggacttt    660

gaaaggctga gccaggcgga tcacctgagg tcagggttcg agaccagcct ggccaacatg    720

gtgaaacccg tctctattaa agatacaaaa attagccagg cggaagaagt cacttagctc    780

ttcgctggtt gtcacacgtc cggaggccga gccgtcgcgt acctaggata cctggaagcc    840

gaagccacac ctcccgcatg gcccctccgg ccagccgggc ccctcagatg agagctgcac    900

ccaggccagc accagtcgct cagccaccag cagcggcacc gccatctaca gttggctctt    960

ctgctgctgc gccccggcag ccaggtctga tggcccagat ggcaaccact gcagctggcg   1020

tggctgtggg ctctgctgtg gggcacatac tgggtcatgc cattactggg ggcttcagtg   1080

gaggaagtaa tgctgagcct gcgaggcctg acatcactta ccaggagcct cagggaaccc   1140

agccggcaca gcagcagcag ccttgcttct gtgagatcaa acagtttctg gagtgtgccg   1200

agaaccaggg tgacatcaag ctctgtgagg gtttcaatga ggtgctgaaa cagtgccgac   1260

ttgcaaacgg attggcctaa tcaagaagtt caacctggag agatggaaaa tcagctctca   1320

tactaattaa tttagtataa aaatagaatt ggtagtgagg gtataaagtg taagcatcag   1380

ttaaacttct cctgtcattc ctagcttcct tgcttcagaa ttgaaatgga agggagggtg   1440

ttcctactct gtagaatctg ggactgggca aatgtttgtg tgccactgca              1490


<210>  4273
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  4273

Met Ala Pro Pro Ala Ser Arg Ala Pro Gln Met Arg Ala Ala Pro Arg 
1               5                   10                  15      


Pro Ala Pro Val Ala Gln Pro Pro Ala Ala Ala Pro Pro Ser Thr Val 
            20                  25                  30          


Gly Ser Ser Ala Ala Ala Pro Arg Gln Pro Gly Leu Met Ala Gln Met 
        35                  40                  45              


Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Ile 
    50                  55                  60                  


Leu Gly His Ala Ile Thr Gly Gly Phe Ser Gly Gly Ser Asn Ala Glu 
65                  70                  75                  80  


Pro Ala Arg Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Pro 
                85                  90                  95      


Ala Gln Gln Gln Gln Pro Cys Phe Cys Glu Ile Lys Gln Phe Leu Glu 
            100                 105                 110         


Cys Ala Glu Asn Gln Gly Asp Ile Lys Leu Cys Glu Gly Phe Asn Glu 
        115                 120                 125             


Val Leu Lys Gln Cys Arg Leu Ala Asn Gly Leu Ala 
    130                 135                 140 


<210>  4274
<211>  1562
<212>  DNA
<213>  Homosapiens

<400>  4274
cataggcgag gcattcctgg ggtttgcgcc gtatcctttt acaaagtcct ggctttggct     60

ggtgcgacca aagaaaggaa accggcgctt gagacttgtc tgggctggct atggtgaagc    120

agtgaaacgg tgcagaattg tgtcaatgag gctagttcag ttgtgcaaga gcatttcctc    180

aaagtaagac agaagctttt agttacgtca acacctgcta atgttaggct ggccagaaat    240

ttcctgacaa ataatgggtg aaggtcgggc gtgtggtcgc tcatgcctgt aatctcagcg    300

ctttgggatc acttgaggtc aggagttcga gaccagcttg gccaactagg cgaaacccca    360

tctctactga aagtacaaaa attagccgtg tgtggtggcg cgcatctgta atcccagcta    420

ctctggaggc tgaggcagga caatcgcttg aacccaggag gcagaggttg cagtgagctg    480

agatcacgcc acttaaaaga aacgaaactt tgctggtgac catgtggtga tgaaactgag    540

cgttttggag cgcagcaagg tgactcccca tgtaattagt atagacagag agtttgtgct    600

ctaaaggtta gaaataaatg ttttcggcct ggtggctcat gcctgtaatc ccaggacttt    660

gaaaggctga gccaggcgga tcacctgagg tcagggttcg agaccagcct ggccaacatg    720

gtgaaacccg tctctattaa agatacaaaa attagccagg cggaagaagt cacttagctc    780

ttcgctggtt gtcacacgtc cggaggccga gccgtcgcgt acctaggata cctggaagcc    840

gaagccacac ctcccgcatg gcccctccgg ccagccgggc ccctcagatg agagctgcac    900

ccaggccagc accagtcgct cagccaccag cagcggcacc gccatctaca gttggctctt    960

ctgctgctgc gccccggcag ccaggtctga tggcccagat ggcaaccact gcagctggcg   1020

tggctgtggg ctctgctgtg gggcacatac tgggtcatgc cattactggg ggcttcagtg   1080

gaggaagtaa tgctgagcct gcgaggcctg acatcactta ccaggagcct cagggaaccc   1140

agccggcaca gcagcagcag ccttgcttct gtgagatcaa acagtttctg gagtgtgccg   1200

agaaccaggg tgacatcaag ctctgtgagg gtttcaatga ggtgctgaaa cagtgccgac   1260

ttgcaaacgg attggcctaa tcaagaagtt caacctggag agatggaaaa tcagctctca   1320

tactaattaa tttagtataa aaatagaatt ggtagtgagg gtataaagtg taagcatcag   1380

ttaaacttct cctgtcattc ctagcttcct tgcttcagaa ttgaaatgga agggagggtg   1440

ttcctactct gtagaatctg ggactgggca aatgtttgtg tggcctcctt aaactagctg   1500

ttatgatttt attctttgtg agttaattag aataaagtca ttttcttcca aaaaagaaaa   1560

aa                                                                  1562


<210>  4275
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  4275

Met Ala Pro Pro Ala Ser Arg Ala Pro Gln Met Arg Ala Ala Pro Arg 
1               5                   10                  15      


Pro Ala Pro Val Ala Gln Pro Pro Ala Ala Ala Pro Pro Ser Thr Val 
            20                  25                  30          


Gly Ser Ser Ala Ala Ala Pro Arg Gln Pro Gly Leu Met Ala Gln Met 
        35                  40                  45              


Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Ile 
    50                  55                  60                  


Leu Gly His Ala Ile Thr Gly Gly Phe Ser Gly Gly Ser Asn Ala Glu 
65                  70                  75                  80  


Pro Ala Arg Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Pro 
                85                  90                  95      


Ala Gln Gln Gln Gln Pro Cys Phe Cys Glu Ile Lys Gln Phe Leu Glu 
            100                 105                 110         


Cys Ala Glu Asn Gln Gly Asp Ile Lys Leu Cys Glu Gly Phe Asn Glu 
        115                 120                 125             


Val Leu Lys Gln Cys Arg Leu Ala Asn Gly Leu Ala 
    130                 135                 140 


<210>  4276
<211>  804
<212>  DNA
<213>  Homosapiens

<400>  4276
aaaaaaagaa gtcacttagc tcttcgctgg ttgtcacacg tccggaggcc gagccgtcgc     60

gtacctagga tacctggaag ccgaagccac acctcccgca tggcccctcc ggccagccgg    120

gcccctcaga tgagagctgc acccaggcca gcaccagtcg ctcagccacc agcagcggca    180

ccgccatcta cagttggctc ttctgctgct gcgccccggc agccaggtct gatggcccag    240

atggcaacca ctgcagctgg cgtggctgtg ggctctgctg tggggcacat actgggtcat    300

gccattactg ggggcttcag tggaggaagt aatgctgagc ctgcgaggcc tgacatcact    360

taccaggagc ctcagggaac ccagccggca cagcagcagc agccttgctt ctgtgagatc    420

aaacagtttc tggagtgtgc cgagaaccag ggtgacatca agctctgtga gggtttcaat    480

gaggtgctga aacagtgccg acttgcaaac ggattggcct aatcaagaag ttcaacctgg    540

agagatggaa aatcagctct catactaatt aatttagtat aaaaatagaa ttggtagtga    600

gggtataaag tgtaagcatc agttaaactt ctcctgtcat tcctagcttc cttgcttcag    660

aattgaaatg gaagggaggg tgttcctact ctgtagaatc tgggactggg caaatgtttg    720

tgtggcctcc ttaaactagc tgttatgatt ttattctttg tgagttaatt agaataaagt    780

cattttcttc caaaaaagaa aaaa                                           804


<210>  4277
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  4277

Met Ala Pro Pro Ala Ser Arg Ala Pro Gln Met Arg Ala Ala Pro Arg 
1               5                   10                  15      


Pro Ala Pro Val Ala Gln Pro Pro Ala Ala Ala Pro Pro Ser Thr Val 
            20                  25                  30          


Gly Ser Ser Ala Ala Ala Pro Arg Gln Pro Gly Leu Met Ala Gln Met 
        35                  40                  45              


Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Ile 
    50                  55                  60                  


Leu Gly His Ala Ile Thr Gly Gly Phe Ser Gly Gly Ser Asn Ala Glu 
65                  70                  75                  80  


Pro Ala Arg Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Pro 
                85                  90                  95      


Ala Gln Gln Gln Gln Pro Cys Phe Cys Glu Ile Lys Gln Phe Leu Glu 
            100                 105                 110         


Cys Ala Glu Asn Gln Gly Asp Ile Lys Leu Cys Glu Gly Phe Asn Glu 
        115                 120                 125             


Val Leu Lys Gln Cys Arg Leu Ala Asn Gly Leu Ala 
    130                 135                 140 


<210>  4278
<211>  802
<212>  DNA
<213>  Homosapiens

<400>  4278
aaaaaaaagt cacttagctc ttcgctggtt gtcacacgtc cggaggccga gccgtcgcgt     60

acctaggata cctggaagcc gaagccacac ctcccgcatg gcccctccgg ccagccgggc    120

ccctcagatg agagctgcac ccaggccagc accagtcgct cagccaccag cagcggcacc    180

gccatctaca gttggctctt ctgctgctgc gccccggcag ccaggtctga tggcccagat    240

ggcaaccact gcagctggcg tggctgtggg ctctgctgtg gggcacatac tgggtcatgc    300

cattactggg ggcttcagtg gaggaagtaa tgctgagcct gcgaggcctg acatcactta    360

ccaggagcct cagggaaccc agccggcaca gcagcagcag ccttgcttct gtgagatcaa    420

acagtttctg gagtgtgccg agaaccaggg tgacatcaag ctctgtgagg gtttcaatga    480

ggtgctgaaa cagtgccgac ttgcaaacgg attggcctaa tcaagaagtt caacctggag    540

agatggaaaa tcagctctca tactaattaa tttagtataa aaatagaatt ggtagtgagg    600

gtataaagtg taagcatcag ttaaacttct cctgtcattc ctagcttcct tgcttcagaa    660

ttgaaatgga agggagggtg ttcctactct gtagaatctg ggactgggca aatgtttgtg    720

tggcctcctt aaactagctg ttatgatttt attctttgtg agttaattag aataaagtca    780

ttttcttcca aaaaagaaaa aa                                             802


<210>  4279
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  4279

Met Ala Pro Pro Ala Ser Arg Ala Pro Gln Met Arg Ala Ala Pro Arg 
1               5                   10                  15      


Pro Ala Pro Val Ala Gln Pro Pro Ala Ala Ala Pro Pro Ser Thr Val 
            20                  25                  30          


Gly Ser Ser Ala Ala Ala Pro Arg Gln Pro Gly Leu Met Ala Gln Met 
        35                  40                  45              


Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Ile 
    50                  55                  60                  


Leu Gly His Ala Ile Thr Gly Gly Phe Ser Gly Gly Ser Asn Ala Glu 
65                  70                  75                  80  


Pro Ala Arg Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Pro 
                85                  90                  95      


Ala Gln Gln Gln Gln Pro Cys Phe Cys Glu Ile Lys Gln Phe Leu Glu 
            100                 105                 110         


Cys Ala Glu Asn Gln Gly Asp Ile Lys Leu Cys Glu Gly Phe Asn Glu 
        115                 120                 125             


Val Leu Lys Gln Cys Arg Leu Ala Asn Gly Leu Ala 
    130                 135                 140 


<210>  4280
<211>  2870
<212>  DNA
<213>  Homosapiens

<400>  4280
tgctcgatga tcttctcttc ccgcacgttc tcgggccggg cgtggcggct cacacctgta     60

atctcagcac tttggaaggc cctggcggaa ggatctcttg acgtcaggac ttccaaaaca    120

gttgggcaac acagcaagac cccgttccca ggctgggggc aaagccgggc tcggtggctc    180

acgcctgtaa ttccagcact ttgggaggcc gaggtgggcg gatcacctga gctcaggagt    240

tcgagaccag cctgaccaac atggtgaaac ccatctctac taaacataca aaaattaccc    300

gagcgtattg gcgggcgcct gtagtcccag ctacatggga ggctgaggca ggagaatcgc    360

ttgaacccgg gaggcgaagg ttgcagtgag ccgagactgc gccactgcac tacagcctgg    420

atgacaagag actcccgtct caaaaaaaaa aaaaaaaaga cacctttctt tgggcttagt    480

gagcaaacat tctacgcagt gcctaatata agccggccca ggcaccaccc aagccttcgg    540

ccaggactgt tttcccgttt cgagaaggct ccatcacact ccacacggga tccagtcaac    600

agccgttcca aacatggcgc gggaaggggt ggaagacaag ccagcgcgac gccgtccagc    660

ctcatccccg gggcacaaag gggagactaa tctccaggaa actcggggta cagaatcgat    720

aaccccacaa gaaactagtt tccgcgagtg ggccttaagg aaaaagtagg tcgggcacaa    780

gcgagctgtt cagacgcact tcacagcaaa gactcgcgga caacacagcg agacgaaaac    840

ggccccgtgc gcaggcgcgc ggaaacacga ctagcgcgct tcgggacgac ccctccccct    900

tccctcaaag gccaaggaag tggctccgac gcgcttgcgc gaggacggaa tgttgagggg    960

agggggaatt ctttcccttc attgtcagag agaaccgccc ccgcacggcg agcgcgcgcg   1020

cgctcacgca ccactctcac actccggcgc gccaaaggct ttccgcttgg cgtctcgcgc   1080

atgcgcggag ggggaagcag tggcgaaatt ggatgctttt tgctgagttt ctcagagaag   1140

tttctggaaa gatggagcca aagggacgct ggggggtggg gagcgccagg aagcaagcgt   1200

ttgaaagaaa gcgaaaaaac ccaagcgcac cgcgacacct ccaaccttca agccacggcc   1260

caagcagagc ccaaggccac tgagaccctc acgccagaga aaaagcacag ggaccgcggc   1320

agccgctcct ccctctgcca ctgctcagcc cccgagactc cccagcacgg ggagagggca   1380

gggggtagcc atgagaaacc tagagcgctc actggacttt tgcgaggtgg aaggaaagcc   1440

gaaacccgcc ctttggagcc gcctgtgcgc acgggccccg tcgagtgggc tcagtacgtt   1500

aggactcagc gtggccgcca aagcattggt tgggggcgtc tttcactaat ttttcctagg   1560

ttttctcttc tatcgggctc tgtggtcctt tcaccaccca tcttcacttt ggtggcctga   1620

cgctaacgct gcgagttggg gaaaccgtag taaccccggg cctgaggggc gtcccgggcg   1680

gcggtgctcc gtttcttcca gcggttgccc ctttaagaaa aagccccccg gagaggggcc   1740

cgtgtggctg agtaaaggtg gcgtgcgccc gcacaaaggc gccgcgttgt tggcgggctc   1800

cggaccctgt tgcccctggg cggggcggcg tgggaagacc ggggcgcctg ggcggggaga   1860

acgacgttgg cgctagcggg gcagggcagg gggagggagt cacgggattt agcaggtgct   1920

tctccgcgac cgagcgactg ccattttgtg gtgcggccgc cgccatttcg cgcggccgag   1980

gggcggggtg tgggcggagc ggcgggcgcg cccgggctgt ccctcggggc ggcgggctaa   2040

cgcggccgct ttgttcttcg cttctcggct cgaggcccca gtctcgaccg ccgaccgcct   2100

cggaaccggg ctgcatccga gctgccacgc ggcgtgtgaa ccttgaagcg cggccgggga   2160

atccgcaagg cgccgactct cttcctcctt gcaagccctt cgaaagtgag atttctcacc   2220

ccacccttgc agggtggaga gaacacgttt caaaaagggg atgcctagaa ctcagccgtg   2280

ggaagtgcct gtctaaagcc ttgtgctggt gccagtagca aacccgtgcg cgtgctcggc   2340

tttgagcgat catggagctc tgcaaatagc tcaactgcag agcgtgcccc ttagagctcc   2400

tgtgctgctg ggaggcctca taaaggtgcc aaaaccaggt gtccccagcg gttggcctct   2460

ttaaaaagaa aaaaaaaaaa aggcggagtg ggatgtcctt gacgtgctga aagacggagt   2520

agaatgagac gttggttttc attggctggc cattaagcac gcactgcgca actgttttcc   2580

agatacgggt ttatagccca ttatttatat cggagccata aacttgaaca atagattgga   2640

atatcttatt tttgcctgtt gagaatatct cccatttaac ttcttttgaa agttcagatg   2700

agtatataaa taatacattg acccagtaga atctattgtg tgcgttccag cgtcatttca   2760

aagagctatt gtttttctga tttcaaaaga aatatttaaa tgtgagtctt tgtgttttaa   2820

tgttaacctt gtggttcgaa atcaacaaag ccaggaaatt caagagaact              2870


<210>  4281
<211>  179
<212>  PRT
<213>  Homosapiens

<400>  4281

Met Arg Gly Gly Gly Ser Ser Gly Glu Ile Gly Cys Phe Leu Leu Ser 
1               5                   10                  15      


Phe Ser Glu Lys Phe Leu Glu Arg Trp Ser Gln Arg Asp Ala Gly Gly 
            20                  25                  30          


Trp Gly Ala Pro Gly Ser Lys Arg Leu Lys Glu Ser Glu Lys Thr Gln 
        35                  40                  45              


Ala His Arg Asp Thr Ser Asn Leu Gln Ala Thr Ala Gln Ala Glu Pro 
    50                  55                  60                  


Lys Ala Thr Glu Thr Leu Thr Pro Glu Lys Lys His Arg Asp Arg Gly 
65                  70                  75                  80  


Ser Arg Ser Ser Leu Cys His Cys Ser Ala Pro Glu Thr Pro Gln His 
                85                  90                  95      


Gly Glu Arg Ala Gly Gly Ser His Glu Lys Pro Arg Ala Leu Thr Gly 
            100                 105                 110         


Leu Leu Arg Gly Gly Arg Lys Ala Glu Thr Arg Pro Leu Glu Pro Pro 
        115                 120                 125             


Val Arg Thr Gly Pro Val Glu Trp Ala Gln Tyr Val Arg Thr Gln Arg 
    130                 135                 140                 


Gly Arg Gln Ser Ile Gly Trp Gly Arg Leu Ser Leu Ile Phe Pro Arg 
145                 150                 155                 160 


Phe Ser Leu Leu Ser Gly Ser Val Val Leu Ser Pro Pro Ile Phe Thr 
                165                 170                 175     


Leu Val Ala 
            


<210>  4282
<211>  962
<212>  DNA
<213>  Homosapiens

<400>  4282
gcctcttctt tatatttcag cctgtttctc cagaactccc tgttggctca gtcctacgtg     60

ggtttactgc acaggtctgt ggcccaacat gtatgaacca tactccatct gtgaggggca    120

tctctaccct ctcagtcact aaggttggaa atttccaagt tatctaggac tcctgcctct    180

tcctcgcttc ccacagtttg tcaccaaaaa ctctggagtc cataccctcc tctcagcagc    240

tgctggccag gttcggtctt cattccctct cacatggact ctgcctctag tgtcccctcc    300

cagcaagggc tgaagaagag gagactgggg tgggagaagg tggaatgggg gctgcctttg    360

tcgctagcct ccgcagtaac ctttcttctg ccacttcaag gtcagagatg aacagcagtg    420

ttggggacct gggtgttggc ggctgcagcc tctgggatga ccctgctcgc ttcatcgtgg    480

tgcccgcggc ctatgccttg gcactgggcc tggggctgcc agccaacgtg gcggccctgg    540

caatgttcat ccgcagcggc gggcgcctgg gccaggccct gcttctctac ctgttcaacc    600

tggctctggt tgatgagttc ttcacgctca cgctgcagct gtggctcacc tactacctgg    660

gcctggcccg gaggccgcct gccacgcggc cggggccacc tactacgtgt ccacctatgc    720

ggcggtggtc ttcgccgcgc tcatcagcgt gtgccgctgc ggcttcgtac gcggtcccgg    780

gcccagggcg gctgcccgcc tggcccggtg cctacggcgc cccgcgcgcg ctgcctgcgc    840

cttcgcctgg ctggcgggcc tggcccctcc ctgcctggag caccgctggg caagctcggg    900

gctggcctcc gccacggtgg ccttcgcggc cgccttcctg ctggtgctcg cggccaacgt    960

ga                                                                   962


<210>  4283
<211>  205
<212>  PRT
<213>  Homosapiens

<400>  4283

Met Gly Ala Ala Phe Val Ala Ser Leu Arg Ser Asn Leu Ser Ser Ala 
1               5                   10                  15      


Thr Ser Arg Ser Glu Met Asn Ser Ser Val Gly Asp Leu Gly Val Gly 
            20                  25                  30          


Gly Cys Ser Leu Trp Asp Asp Pro Ala Arg Phe Ile Val Val Pro Ala 
        35                  40                  45              


Ala Tyr Ala Leu Ala Leu Gly Leu Gly Leu Pro Ala Asn Val Ala Ala 
    50                  55                  60                  


Leu Ala Met Phe Ile Arg Ser Gly Gly Arg Leu Gly Gln Ala Leu Leu 
65                  70                  75                  80  


Leu Tyr Leu Phe Asn Leu Ala Leu Val Asp Glu Phe Phe Thr Leu Thr 
                85                  90                  95      


Leu Gln Leu Trp Leu Thr Tyr Tyr Leu Gly Leu Ala Arg Arg Pro Pro 
            100                 105                 110         


Ala Thr Arg Pro Gly Pro Pro Thr Thr Cys Pro Pro Met Arg Arg Trp 
        115                 120                 125             


Ser Ser Pro Arg Ser Ser Ala Cys Ala Ala Ala Ala Ser Tyr Ala Val 
    130                 135                 140                 


Pro Gly Pro Gly Arg Leu Pro Ala Trp Pro Gly Ala Tyr Gly Ala Pro 
145                 150                 155                 160 


Arg Ala Leu Pro Ala Pro Ser Pro Gly Trp Arg Ala Trp Pro Leu Pro 
                165                 170                 175     


Ala Trp Ser Thr Ala Gly Gln Ala Arg Gly Trp Pro Pro Pro Arg Trp 
            180                 185                 190         


Pro Ser Arg Pro Pro Ser Cys Trp Cys Ser Arg Pro Thr 
        195                 200                 205 


<210>  4284
<211>  1875
<212>  DNA
<213>  Homosapiens

<400>  4284
agaggcaaga aaggaacagt ctgaggtttg agtctgaccc aggacctctt tgtggtcaaa     60

aagtgagggg ggaggaaaca ggatgaaagg cttgagagtg gcaaaagctt ttcagcccag    120

ccaagggtgc tccaggcaag cgctggggca cctctctggg agaggacctt caccaaggtc    180

agagatgaac agcagtgttg gggacctggg tgttggcggc tgcagcctct gggatgaccc    240

tgctcgcttc atcgtggtgc ccgcggccta tgccttggca ctgggcctgg ggctgccagc    300

caacgtggcg gccctggcaa tgttcatccg cagcggcggg cgcctgggcc aggccctgct    360

tctctacctg ttcaacctgg ctctggttga tgagttcttc acgctcacgc tgcagctgtg    420

gctcacctac tacctgggcc tggcccggag gccgcctgcc acgcggccgg ggccacctac    480

tacgtgtcca cctatgcggc ggtggtcttc gccgcgctca tcagcgtgtg ccgctgcggc    540

ttcgtacgcg gtcccgggcc cagggcggct gcccgcctgg cccggtgcct acggcgcccc    600

gcgcgcgctg cctgcgcctt cgcctggctg gcgggcctgg cccctccctg cctggagcac    660

cgctgggcaa gctcggggct ggcctccgcc acggtggcct tcgcggccgc cttcctgctg    720

gtgctcgcgg ccaacgtgag cctggcgcgg gcgctcaagg cgccctctgg cccgggcccg    780

ggccctgcaa ccgccggcgc gcaccggcgc gcggccaaga ccatggtcct ggggttcctg    840

ctggtcttcg ccctcagtct ggcgcccaac cacctgctgc tggcgcccta ggtggctggg    900

ggggaagaca acggagaccg gtgtcgcgcc gcctccacgc tcgacatcct gcacaccctc    960

agcctggcgc tgctgagcct caacagctgc ctggacccac tcatctgctg cttcttcgtg   1020

cgcctcttcc accaggactg ctgctgggca ctgagctgcc gcctggtgaa gggggcgccc   1080

agggcgcatg gggcctcctt ggcctcctct tggagagtct cctggcctcc cctcctgtct   1140

cacccccctg tcaccctccc agtggcatcc agggtggaga aagctctttg gaaagaccta   1200

gattctaatc ctgacgcaac cacatactac ccctgtagct gtgaacctcc gggctcatct   1260

gtaccaagga catagaacat tctttgtaac ccgaatgttc cctggatgtt gccagctttt   1320

ggatacaaat aatataccac tgtgtttttt ttaaacctct tgggataaaa cccaaagtcc   1380

ttatcatggc ctacaaggcc ctgtctgatt tggctcccct ttctctccct aacccaccac   1440

ccctgcgtct ccctgcaggc agtcaccttc ttaggcccgg gaaaatgccg gtctcctact   1500

cttcatggcc tttgtacctg acttggccag gaatgatctc tgttcctctc tttcactaag   1560

ttagttcttc ttcaccctca cttcctctaa agtaactcct tatagggaag cctttcttgg   1620

ctggcaacac acacacacac acacacacac acatacacac acgactgaat cagatcggat   1680

tgctctttga tagctctttt cataattgta atcaagcaat taattgggta atgcgttgtt   1740

gttgttttct ttctctcttg ccagaatgta ttcatgttga cccataagac attatcattt   1800

ttataagtcc ccaaaagttg aatattggaa attttatttc cacccaattc aacttaataa   1860

attctgtgtt tacct                                                    1875


<210>  4285
<211>  218
<212>  PRT
<213>  Homosapiens

<400>  4285

Met Lys Gly Leu Arg Val Ala Lys Ala Phe Gln Pro Ser Gln Gly Cys 
1               5                   10                  15      


Ser Arg Gln Ala Leu Gly His Leu Ser Gly Arg Gly Pro Ser Pro Arg 
            20                  25                  30          


Ser Glu Met Asn Ser Ser Val Gly Asp Leu Gly Val Gly Gly Cys Ser 
        35                  40                  45              


Leu Trp Asp Asp Pro Ala Arg Phe Ile Val Val Pro Ala Ala Tyr Ala 
    50                  55                  60                  


Leu Ala Leu Gly Leu Gly Leu Pro Ala Asn Val Ala Ala Leu Ala Met 
65                  70                  75                  80  


Phe Ile Arg Ser Gly Gly Arg Leu Gly Gln Ala Leu Leu Leu Tyr Leu 
                85                  90                  95      


Phe Asn Leu Ala Leu Val Asp Glu Phe Phe Thr Leu Thr Leu Gln Leu 
            100                 105                 110         


Trp Leu Thr Tyr Tyr Leu Gly Leu Ala Arg Arg Pro Pro Ala Thr Arg 
        115                 120                 125             


Pro Gly Pro Pro Thr Thr Cys Pro Pro Met Arg Arg Trp Ser Ser Pro 
    130                 135                 140                 


Arg Ser Ser Ala Cys Ala Ala Ala Ala Ser Tyr Ala Val Pro Gly Pro 
145                 150                 155                 160 


Gly Arg Leu Pro Ala Trp Pro Gly Ala Tyr Gly Ala Pro Arg Ala Leu 
                165                 170                 175     


Pro Ala Pro Ser Pro Gly Trp Arg Ala Trp Pro Leu Pro Ala Trp Ser 
            180                 185                 190         


Thr Ala Gly Gln Ala Arg Gly Trp Pro Pro Pro Arg Trp Pro Ser Arg 
        195                 200                 205             


Pro Pro Ser Cys Trp Cys Ser Arg Pro Thr 
    210                 215             


<210>  4286
<211>  540
<212>  DNA
<213>  Homosapiens

<400>  4286
atggtcctcg gcctggcagc cagccgcccc cggccaccta ccggggctca gggccacata     60

gcggggcccc ggctctcggc ggcctccgcc tcctcctggt ccatgggctc ggggaccccc    120

aaccttcgct cccctcaccc ggaggaggag gaggaagagg aagaaggtag tgcgggctcc    180

ccacccggac agctacctct cgcctcagcc tccctggaca gcgacggcgg ccggaaacac    240

cgcctcctcc cacctccccg ggaccgaccc ggaaacacac tctccatgct aaccaagccc    300

tcccgcccct cccccgggaa gggcaatgcc ggccgcgaga ccaaggggga ggaggggcag    360

tgctgggcgg gtaaaactac gcacaagcga aggaatctgg gcccccagcc tctcgccgcc    420

cgctctccag aggcagtctg caccttgcct ccttcgctcg agccccagcc cccagactcg    480

ggcaataccc acaagcaaga tggcggcaac ggcggcaccc cctactgctt agcaccctga    540


<210>  4287
<211>  179
<212>  PRT
<213>  Homosapiens

<400>  4287

Met Val Leu Gly Leu Ala Ala Ser Arg Pro Arg Pro Pro Thr Gly Ala 
1               5                   10                  15      


Gln Gly His Ile Ala Gly Pro Arg Leu Ser Ala Ala Ser Ala Ser Ser 
            20                  25                  30          


Trp Ser Met Gly Ser Gly Thr Pro Asn Leu Arg Ser Pro His Pro Glu 
        35                  40                  45              


Glu Glu Glu Glu Glu Glu Glu Gly Ser Ala Gly Ser Pro Pro Gly Gln 
    50                  55                  60                  


Leu Pro Leu Ala Ser Ala Ser Leu Asp Ser Asp Gly Gly Arg Lys His 
65                  70                  75                  80  


Arg Leu Leu Pro Pro Pro Arg Asp Arg Pro Gly Asn Thr Leu Ser Met 
                85                  90                  95      


Leu Thr Lys Pro Ser Arg Pro Ser Pro Gly Lys Gly Asn Ala Gly Arg 
            100                 105                 110         


Glu Thr Lys Gly Glu Glu Gly Gln Cys Trp Ala Gly Lys Thr Thr His 
        115                 120                 125             


Lys Arg Arg Asn Leu Gly Pro Gln Pro Leu Ala Ala Arg Ser Pro Glu 
    130                 135                 140                 


Ala Val Cys Thr Leu Pro Pro Ser Leu Glu Pro Gln Pro Pro Asp Ser 
145                 150                 155                 160 


Gly Asn Thr His Lys Gln Asp Gly Gly Asn Gly Gly Thr Pro Tyr Cys 
                165                 170                 175     


Leu Ala Pro 
            


<210>  4288
<211>  540
<212>  DNA
<213>  Homosapiens

<400>  4288
atggtcctcg gcctggcagc cagccgcccc cggccaccta ccggggctca gggccacata     60

gcggggcccc ggctctcggc ggcctccgcc tcctcctggt ccatgggctc ggggaccccc    120

aaccttcgct cccctcaccc ggaggaggag gaggaagagg aagaaggtag tgcgggctcc    180

ccacccggac agctacctct cgcctcagcc tccctggaca gcgacggcgg ccggaaacac    240

cgcctcctcc cacctccccg ggaccgaccc ggaaacacac tctccatgct aaccaagccc    300

tcccgcccct cccccgggaa gggcaatgcc ggccgcgaga ccaaggggga ggaggggcag    360

tgctgggcgg gtaaaactac gcacaagcga aggaatctgg gcccccagcc tctcgccgcc    420

cgctctccag aggcagtctg caccttgcct ccttcgctcg agccccagcc cccagactcg    480

ggcaataccc acaagcaaga tggcggcaac ggcggcaccc cctactgctt agcaccctga    540


<210>  4289
<211>  179
<212>  PRT
<213>  Homosapiens

<400>  4289

Met Val Leu Gly Leu Ala Ala Ser Arg Pro Arg Pro Pro Thr Gly Ala 
1               5                   10                  15      


Gln Gly His Ile Ala Gly Pro Arg Leu Ser Ala Ala Ser Ala Ser Ser 
            20                  25                  30          


Trp Ser Met Gly Ser Gly Thr Pro Asn Leu Arg Ser Pro His Pro Glu 
        35                  40                  45              


Glu Glu Glu Glu Glu Glu Glu Gly Ser Ala Gly Ser Pro Pro Gly Gln 
    50                  55                  60                  


Leu Pro Leu Ala Ser Ala Ser Leu Asp Ser Asp Gly Gly Arg Lys His 
65                  70                  75                  80  


Arg Leu Leu Pro Pro Pro Arg Asp Arg Pro Gly Asn Thr Leu Ser Met 
                85                  90                  95      


Leu Thr Lys Pro Ser Arg Pro Ser Pro Gly Lys Gly Asn Ala Gly Arg 
            100                 105                 110         


Glu Thr Lys Gly Glu Glu Gly Gln Cys Trp Ala Gly Lys Thr Thr His 
        115                 120                 125             


Lys Arg Arg Asn Leu Gly Pro Gln Pro Leu Ala Ala Arg Ser Pro Glu 
    130                 135                 140                 


Ala Val Cys Thr Leu Pro Pro Ser Leu Glu Pro Gln Pro Pro Asp Ser 
145                 150                 155                 160 


Gly Asn Thr His Lys Gln Asp Gly Gly Asn Gly Gly Thr Pro Tyr Cys 
                165                 170                 175     


Leu Ala Pro 
            


<210>  4290
<211>  1898
<212>  DNA
<213>  Homosapiens

<400>  4290
gacatttgac attttattgt agcagctttc tgggttaata tctctttgtg attgatagaa     60

gtggttggaa gaggaagagt agggaaaagt gtgacattac agattaaaca gtgaaaatca    120

gtaccataat gactccttta cacccatgag atacgtacca tgatgaccag ggctcggtga    180

aagaaagatt tctttttttt tttttgagat agtctcactt tgttgcccag tctggagtgc    240

agtggcgcaa tctcggctca cggcaacctc tgcctcccgg gttcaagtga ttctcctgtc    300

tcagcctccc aagtagctgg gactacaggt gcatgccacc acacctggct aatttttgta    360

tttttagtgg agacagggag tcaccatgtt ggccaggctg gtctcgatct cctgacctca    420

agtgatccag ctgcctcagc ctcccaaagt gctgagatta caggcgtgag ccactgtgcc    480

cagccaaaag aacgatttct tagatggagg acctaggaac caacagatgg gctgctgtat    540

tactcttacc cctttcattt tcctgtatgc ttcttcccaa ggcagcatca aattttgaat    600

taatttttgc tgcttaataa ggacttaaac tggtacccaa gtcagaaaga ctctgcctct    660

aattttctgg ggcttgggga tgaagataaa gtgttacacc cagtgtttgt ccaccacagt    720

ctgtggggca gagagaccct tcctgggact gaattctcaa tttgaagcac tgttgttcaa    780

agatctccct tctgggtctg acaagaagaa acataaccct tatttattgc attcttctgg    840

cttacataca ttgccctcac taatcaatgg acatttcagc atttcattac taattttgag    900

agaaggccac catggaattt aataaaaata ttattgaaga gaattgccat cattctccat    960

tttccctgaa ctaccacaag cttctcagaa ttttagacaa atgtttttcc cctcagaact   1020

gagcatcagt gctgctttgg aaaaacattc catgtgaata ctgtggtttc agtgtcagga   1080

cctgtacttg ggcagttgga agagagtgtg ccagtttttt actgggagat gggaacacca   1140

atttaattga tgcaattagg ttgtaggttt tttacagttt ttcttttctt ttctttttct   1200

ttttcttttc ttttcttttc tttttttttt tttgagacat aggctggctc tgtcacctag   1260

gctggaatac aatggcatga tctcggctta ctgcaacctc cgcctcctag gttcaagcaa   1320

ttctgcctcg gcctcccaaa tagcagggat tacaggcacc tgccaccact cccagctaat   1380

tttttgtatt tttattagag atgaggtttc gccatgttgg ccaggctggt cttgaactcc   1440

tgacctgagg tgatccaccc gtctcggcct cccaaagtgc tgggattata ggcatgagcc   1500

accgcacccg gccggttttc tacagttttc taatactcaa gatgttgact ttgacaatac   1560

ttatgtttgt atacttgtaa tcttataatg gggaaaatgt gtataaagat gttttaatat   1620

gtatgtagtt tttcaataaa tcttaatgcc ttgaagggaa gatttgctgt ccagcttgaa   1680

tgctcattct tgggtcagtg cctgtctaac cttgaggagc atttcatttt caggttatct   1740

ccatcccagg gaaaccctct gggtctaaac tgagaagctg ctgcaattgt cccctcactg   1800

gcttctcagt cctagtgaat tgatcaagtt aacttaccaa gtggtttggg ttcagctcag   1860

gtgaagagga taattgagtt tacataaatg gtaccttc                           1898


<210>  4291
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  4291

Met Lys Ile Lys Cys Tyr Thr Gln Cys Leu Ser Thr Thr Val Cys Gly 
1               5                   10                  15      


Ala Glu Arg Pro Phe Leu Gly Leu Asn Ser Gln Phe Glu Ala Leu Leu 
            20                  25                  30          


Phe Lys Asp Leu Pro Ser Gly Ser Asp Lys Lys Lys His Asn Pro Tyr 
        35                  40                  45              


Leu Leu His Ser Ser Gly Leu His Thr Leu Pro Ser Leu Ile Asn Gly 
    50                  55                  60                  


His Phe Ser Ile Ser Leu Leu Ile Leu Arg Glu Gly His His Gly Ile 
65                  70                  75                  80  


<210>  4292
<211>  1900
<212>  DNA
<213>  Homosapiens

<400>  4292
gacatttgac attttattgt agcagctttc tgggttaata tctctttgtg attgatagaa     60

gtggttggaa gaggaagagt agggaaaagt gtgacattac agattaaaca gtgaaaatca    120

gtaccataat gactccttta cacccatgag atacgtacca tgatgaccag ggctcggtga    180

aagaaagatt tctttttttt tttttgagat agtctcactt tgttgcccag tctggagtgc    240

agtggcgcaa tctcggctca cggcaacctc tgcctcccgg gttcaagtga ttctcctgtc    300

tcagcctccc aagtagctgg gactacaggt gcatgccacc acacctggct aatttttgta    360

tttttagtgg agacagggag tcaccatgtt ggccaggctg gtctcgatct cctgacctca    420

agtgatccag ctgcctcagc ctcccaaagt gctgagatta caggcgtgag ccactgtgcc    480

cagccaaaag aacgatttct tagatggagg acctaggaac caacagatgg gctgctgtat    540

tactcttacc cctttcattt tcctgtatgc ttcttcccaa ggcagcatca aattttgaat    600

taatttttgc tgcttaataa ggacttaaac tggtacccaa gtcagaaaga ctctgcctct    660

aattttctgg ggcttgggga tgaagataaa gtgttacacc cagtgtttgt ccaccacagt    720

ctgtggggca gagagaccct tcctgggact gaattctcaa tttgaagcac tgttgttcaa    780

agatctccct tctgggtctg acaagaagaa acataaccct tatttattgc attcttctgg    840

cttacataca ttgccctcac taatcaatgg acatttcagc atttcattac taattttgag    900

agaaggccac catggaattt aataaaaata ttattgaaga gaattgccat cattctccat    960

tttccctgaa ctaccacaag cttctcagaa ttttagacaa atgtttttcc cctcagaact   1020

gagcatcagt gctgctttgg aaaaacattc catgtgaata ctgtggtttc agtgtcagga   1080

cctgtacttg ggcagttgga agagagtgtg ccagtttttt actgggagat gggaacacca   1140

atttaattga tgcaattagg ttgtaggttt tttacagttt ttcttttctt ttctttttct   1200

ttttcttttc ttttcttttc tttttttttt tttttgagac ataggctggc tctgtcacct   1260

aggctggaat acaatggcac gatctcggct tactgcaacc tccgcctcct aggttcaagc   1320

aattctgcct cggcctccca aatagcaggg attacaggca cctgccacca ctcccagcta   1380

attttttgta tttttattag agatgaggtt tcgccatgtt ggccaggctg gtcttgaact   1440

cctgacctga ggtgatccac ccgtctcggc ctcccaaagt gctgggatta taggcatgag   1500

ccaccgcacc cggccggttt tctacagttt tctaatactc aagatgttga ctttgacaat   1560

acttatgttt gtatacttgt aatcttataa tggggaaaat gtgtataaag atgttttaat   1620

atgtatgtag tttttcaata aatcttaatg ccttgaaggg aagatttgct gtccagcttg   1680

aatgctcatt cttgggtcag tgcctgtcta accttgagga gcatttcatt ttcaggttat   1740

ctccatccca gggaaaccct ctgggtctaa actgagaagc tgctgcaatt gtcccctcac   1800

tggcttctca gtcctagtga attgatcaag ttaacttacc aagtggtttg ggttcagctc   1860

aggtgaagag gataattgag tttacataaa tggtaccttc                         1900


<210>  4293
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  4293

Met Lys Ile Lys Cys Tyr Thr Gln Cys Leu Ser Thr Thr Val Cys Gly 
1               5                   10                  15      


Ala Glu Arg Pro Phe Leu Gly Leu Asn Ser Gln Phe Glu Ala Leu Leu 
            20                  25                  30          


Phe Lys Asp Leu Pro Ser Gly Ser Asp Lys Lys Lys His Asn Pro Tyr 
        35                  40                  45              


Leu Leu His Ser Ser Gly Leu His Thr Leu Pro Ser Leu Ile Asn Gly 
    50                  55                  60                  


His Phe Ser Ile Ser Leu Leu Ile Leu Arg Glu Gly His His Gly Ile 
65                  70                  75                  80  


<210>  4294
<211>  2203
<212>  DNA
<213>  Homosapiens

<400>  4294
ttccaagccc acggccccgg tcgcggcctc gccgccctcc cgcgccccgc accgggagcg     60

ggcctagagc actcgcctcg cccctccgcg agcagggctc tggcgcccgc ccctgtccgc    120

accgctggca gcctgaagag agtcgctggc catggtcgct gctaggtagg atatatctgc    180

atcttgaaag gaagataaaa caaaagcctt ctttggaata gatggatttt tgtcactttc    240

tgtgtgaact aaagtgattc aatgtctctt ttggattgct tctgcacttc aagaacacaa    300

gatgaatcac tcagacctga aaaacagtct gaaaccagta tccatcaata cttggttgat    360

gagccaaccc tttcctggtc acctccatcc actagagcca gtgaagtact atgttccacc    420

aacgtttctc actacgagct ccaagtagaa acaggaagag gatttgacaa cttgacttct    480

gtccatcttg catggcatac tcccacggga acactggtaa ctataaaaat tacaaatctg    540

gaaaactgca atgaagaacg cctgaaagct ttacagaaag ccgtgattct atcccacttt    600

ttccggcatc ccaatattac aacttactgg acagttttca ctgttggcag ctggctttgg    660

gttatttctc catttatggc ctatggttca gcaagtcaac tcttgaggac ctgttttcct    720

gaaggaatga gtgaaacttt aataagaaac attatctttg gagctgtgag agggttgaac    780

tatctgtacc aaaatggctg tattcacagg agtattaaag ccagccatat cctcatttct    840

ggtgatggcc tagtgaccct ctctggcctg tcccatctgc atagtttggt taagcatgga    900

cagaggcata gggctgtgta tgatttccca cagttcagca catcagtgca gccgtggctg    960

agtccagaac tactgagaca ggatttacat gggtataatg tgaagtcaga tatttacagt   1020

gttgggatta cagcatgtga attagccagt gggcaggtgc ctttccagga catgcataga   1080

actcagatgc tgttacagaa actgaaaggt cctccttata gcccattgga tatcagtatt   1140

ttccctcaat cagaatccag aatgaaaaat tcccggtcag gtgtagactc tggaattgga   1200

gaaagtgtgc ttgtctccag tggaactcac acagtaaata gtgaccgatt acacacacca   1260

tcctcaaaaa ctttctctcc tgccttcttt agcttggtac agctctgttt gcaacaagat   1320

cctgagaaaa ggccatcagc aagcagttta ttgtcccatg ttttcttcaa acagatgaaa   1380

gaagaaagcc aggattcaat actttcacgg ttgcctcctg cttataacaa gccatcaata   1440

ccattgcctc cagtgttacc ttggactgag ccagaatgtg attttcctga tgaaaaagac   1500

tcatacttgg aattctaggg ctgccaaatc atttcatgtc ctatatactt gacactttct   1560

ccttgctgct ttttcttctg tatttctagg tacaaatacg agaattatac ttgaaaatac   1620

agttggtgca ctggagaatc tattatttaa aaccactctg ttcaaagggg caccagtttg   1680

tagtccctct gttttgcaca gagtactatg acaaggaaac atcagaatta ccaatctagc   1740

tagtgtcatt tattctggaa tttttttcta agctgtgact aactcttttt atctctcaat   1800

ataatttttg agccagttaa tttttttcag tattttgctg ttccttggga atgagccctc   1860

agaggacagt gcttccaagt acatcttctt ctcccagatt ctctggcctt tttaatgagc   1920

tattgttaaa ccaacaggct agtttatctt acatcagacc cttttctggt agagggaaaa   1980

tgtttgtgct ttcctttttt cttctgttaa tacttatggt aacacctaac tgagcctcac   2040

tcacattaaa tgattcactt gaaatatata cagaaattgt aatttgcttt tttttaaaaa   2100

agggggctaa agtaacactt tcctactttg taaattatag atcttaaatt catgcacccc   2160

gtgggagctc aataaagata tactgaattg agaaaaaaaa aaa                     2203


<210>  4295
<211>  418
<212>  PRT
<213>  Homosapiens

<400>  4295

Met Ser Leu Leu Asp Cys Phe Cys Thr Ser Arg Thr Gln Asp Glu Ser 
1               5                   10                  15      


Leu Arg Pro Glu Lys Gln Ser Glu Thr Ser Ile His Gln Tyr Leu Val 
            20                  25                  30          


Asp Glu Pro Thr Leu Ser Trp Ser Pro Pro Ser Thr Arg Ala Ser Glu 
        35                  40                  45              


Val Leu Cys Ser Thr Asn Val Ser His Tyr Glu Leu Gln Val Glu Thr 
    50                  55                  60                  


Gly Arg Gly Phe Asp Asn Leu Thr Ser Val His Leu Ala Trp His Thr 
65                  70                  75                  80  


Pro Thr Gly Thr Leu Val Thr Ile Lys Ile Thr Asn Leu Glu Asn Cys 
                85                  90                  95      


Asn Glu Glu Arg Leu Lys Ala Leu Gln Lys Ala Val Ile Leu Ser His 
            100                 105                 110         


Phe Phe Arg His Pro Asn Ile Thr Thr Tyr Trp Thr Val Phe Thr Val 
        115                 120                 125             


Gly Ser Trp Leu Trp Val Ile Ser Pro Phe Met Ala Tyr Gly Ser Ala 
    130                 135                 140                 


Ser Gln Leu Leu Arg Thr Cys Phe Pro Glu Gly Met Ser Glu Thr Leu 
145                 150                 155                 160 


Ile Arg Asn Ile Ile Phe Gly Ala Val Arg Gly Leu Asn Tyr Leu Tyr 
                165                 170                 175     


Gln Asn Gly Cys Ile His Arg Ser Ile Lys Ala Ser His Ile Leu Ile 
            180                 185                 190         


Ser Gly Asp Gly Leu Val Thr Leu Ser Gly Leu Ser His Leu His Ser 
        195                 200                 205             


Leu Val Lys His Gly Gln Arg His Arg Ala Val Tyr Asp Phe Pro Gln 
    210                 215                 220                 


Phe Ser Thr Ser Val Gln Pro Trp Leu Ser Pro Glu Leu Leu Arg Gln 
225                 230                 235                 240 


Asp Leu His Gly Tyr Asn Val Lys Ser Asp Ile Tyr Ser Val Gly Ile 
                245                 250                 255     


Thr Ala Cys Glu Leu Ala Ser Gly Gln Val Pro Phe Gln Asp Met His 
            260                 265                 270         


Arg Thr Gln Met Leu Leu Gln Lys Leu Lys Gly Pro Pro Tyr Ser Pro 
        275                 280                 285             


Leu Asp Ile Ser Ile Phe Pro Gln Ser Glu Ser Arg Met Lys Asn Ser 
    290                 295                 300                 


Arg Ser Gly Val Asp Ser Gly Ile Gly Glu Ser Val Leu Val Ser Ser 
305                 310                 315                 320 


Gly Thr His Thr Val Asn Ser Asp Arg Leu His Thr Pro Ser Ser Lys 
                325                 330                 335     


Thr Phe Ser Pro Ala Phe Phe Ser Leu Val Gln Leu Cys Leu Gln Gln 
            340                 345                 350         


Asp Pro Glu Lys Arg Pro Ser Ala Ser Ser Leu Leu Ser His Val Phe 
        355                 360                 365             


Phe Lys Gln Met Lys Glu Glu Ser Gln Asp Ser Ile Leu Ser Arg Leu 
    370                 375                 380                 


Pro Pro Ala Tyr Asn Lys Pro Ser Ile Pro Leu Pro Pro Val Leu Pro 
385                 390                 395                 400 


Trp Thr Glu Pro Glu Cys Asp Phe Pro Asp Glu Lys Asp Ser Tyr Leu 
                405                 410                 415     


Glu Phe 
        


<210>  4296
<211>  1302
<212>  DNA
<213>  Homosapiens

<400>  4296
atggagctca gtgatgggca caaagcaaga ctcatggagg aggatgtgtt tggcagctct     60

ggattttgtg ggagaatata tgtggctttc aggctggact cggtcacttg tagctgcgta    120

gccagcagtc aaggaaggaa atatggttat actttccttg ctaaggaaat ccaaccctcc    180

acaaggcagc tttcttccca tccccttgac cttttaggaa aaagcaccct gagagcacaa    240

ctgaacaaaa ctgtagccca gggcattgaa aacctctcgg agagggccag gtgtgaccag    300

aaaaggctgt ccatcttcac cccaagccca ctggctcctg agatacgaca tccagaccca    360

gtgcagctgg acctggccca ggaagatcat gcggtttctg ggaagcactg gagaaggaaa    420

aggctgaaga aaggaagacc ggaaaagaaa tacaagtcct tccgccttgg caaagatgat    480

agtaccgttc ccttcagtgt tccggttctg ctctattgga taagttccgg tttgactatg    540

actacgtgaa aatgtggaac cagaccttca ccccacattc cagctccagc tctaccacag    600

aggaagtgca atatcacctt agttattcaa cacattatgc tcctcgtgat acaaccagag    660

ttcacatcag caatcttggc agctctcacc acgctgctga ctcacgactc tctcatgtcc    720

caatttcctg tccattgttc tttcctctac ttggcctgat ttctaaaggc ctctcttggt    780

tgcattaagc gggattcctg agggattccc ttggcagtta ccttggggga gctcttaggt    840

ttggggctga tccatgtcct ctaaatgtag gacttcaaag ctcccaaaga taggcaggcc    900

cagtgggaag ctgggaaatg ctctctgacc cctctgggag ggctggcagt cagagggcct    960

tttggaaaga gtcagacctg atccataagt ccctggaaaa caccctgccc agggagcaaa   1020

tgccactgtg gccttgactg aggcttcaga agagtttggg agctgcaatt catccacaca   1080

cgcattcatt ttcaagtagt ggtttgcagt tcaggctttg gagccacata agcctggctt   1140

caaagccact ttccagcttt gtaggaagtc tctacatttt taaacctcca tttttttttc   1200

ctgtaaaact ggggtcttca tggtacttaa cttcatcgtg atgttgagag aatgaaaaga   1260

aaaaggataa ataaatggct tagcctcgtg ccttggcaca ta                      1302


<210>  4297
<211>  182
<212>  PRT
<213>  Homosapiens

<400>  4297

Met Glu Leu Ser Asp Gly His Lys Ala Arg Leu Met Glu Glu Asp Val 
1               5                   10                  15      


Phe Gly Ser Ser Gly Phe Cys Gly Arg Ile Tyr Val Ala Phe Arg Leu 
            20                  25                  30          


Asp Ser Val Thr Cys Ser Cys Val Ala Ser Ser Gln Gly Arg Lys Tyr 
        35                  40                  45              


Gly Tyr Thr Phe Leu Ala Lys Glu Ile Gln Pro Ser Thr Arg Gln Leu 
    50                  55                  60                  


Ser Ser His Pro Leu Asp Leu Leu Gly Lys Ser Thr Leu Arg Ala Gln 
65                  70                  75                  80  


Leu Asn Lys Thr Val Ala Gln Gly Ile Glu Asn Leu Ser Glu Arg Ala 
                85                  90                  95      


Arg Cys Asp Gln Lys Arg Leu Ser Ile Phe Thr Pro Ser Pro Leu Ala 
            100                 105                 110         


Pro Glu Ile Arg His Pro Asp Pro Val Gln Leu Asp Leu Ala Gln Glu 
        115                 120                 125             


Asp His Ala Val Ser Gly Lys His Trp Arg Arg Lys Arg Leu Lys Lys 
    130                 135                 140                 


Gly Arg Pro Glu Lys Lys Tyr Lys Ser Phe Arg Leu Gly Lys Asp Asp 
145                 150                 155                 160 


Ser Thr Val Pro Phe Ser Val Pro Val Leu Leu Tyr Trp Ile Ser Ser 
                165                 170                 175     


Gly Leu Thr Met Thr Thr 
            180         


<210>  4298
<211>  304
<212>  DNA
<213>  Homosapiens

<400>  4298
tgggaaaatg actgagtgcc catagatgaa gtgctttcaa gactgtctgg cacctagagg     60

tatcatcgca gaagccttgg atatgaacag aagcaggcag aggatgaagc tgatggtgtg    120

catggtcact gtgctcctgc ccatttttga gcttctggaa tacaagctgt gcctttgcct    180

ggaatgtccc tcccagtctg actaggcatc ttctgatggg gtttgacctg gttgcttcta    240

acactaggat ggacctcttg gcaatctctg gatatctttc tgtggtttgt tataatggta    300

atta                                                                 304


<210>  4299
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  4299

Met Lys Cys Phe Gln Asp Cys Leu Ala Pro Arg Gly Ile Ile Ala Glu 
1               5                   10                  15      


Ala Leu Asp Met Asn Arg Ser Arg Gln Arg Met Lys Leu Met Val Cys 
            20                  25                  30          


Met Val Thr Val Leu Leu Pro Ile Phe Glu Leu Leu Glu Tyr Lys Leu 
        35                  40                  45              


Cys Leu Cys Leu Glu Cys Pro Ser Gln Ser Asp 
    50                  55                  


<210>  4300
<211>  672
<212>  DNA
<213>  Homosapiens

<400>  4300
atggcttcca aactcctgcg cgcggtcatc ctcgggccgc ccggctcggg caagggcacc     60

gtgtgccaga ggatcgccca gaactttggt ctccagcatc tctccagcgg ccacttcttg    120

cgggagaaca tcaaggccag caccgaagtt ggtgagatgg caaagcagta tatagagaaa    180

agtcttttgg ttccagacca tgtgatcaca cgcctaatga tgtccgagtt ggagaacagg    240

cgtggccagc actggctcct tgatggtttt cctaggacat taggacaagc cgaagccctg    300

gacaaaatct gtgaagtgga tctagtgatc agtttgaata ttccatttga aacacttaaa    360

gatcgtctca gccgccgttg gattcaccct cctagcggaa gggtatataa cctggacttc    420

aatccacctc atgtacatgg tattgatgac gtcactggtg aaccgttagt ccagcaggag    480

gatgataaac ccgaagcagt tgctgccagg ctaagacagt acaaagacgt ggcaaagcca    540

gtcattgaat tatacaagag ccgaggagtg ctccaccaat tttccggaac ggagacgaac    600

aaaatctggc cctacgttta cacacttttc tcaaacaaga tcacacctat tcagtccaaa    660

gaagcatatt aa                                                        672


<210>  4301
<211>  223
<212>  PRT
<213>  Homosapiens

<400>  4301

Met Ala Ser Lys Leu Leu Arg Ala Val Ile Leu Gly Pro Pro Gly Ser 
1               5                   10                  15      


Gly Lys Gly Thr Val Cys Gln Arg Ile Ala Gln Asn Phe Gly Leu Gln 
            20                  25                  30          


His Leu Ser Ser Gly His Phe Leu Arg Glu Asn Ile Lys Ala Ser Thr 
        35                  40                  45              


Glu Val Gly Glu Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val 
    50                  55                  60                  


Pro Asp His Val Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg 
65                  70                  75                  80  


Arg Gly Gln His Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln 
                85                  90                  95      


Ala Glu Ala Leu Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu 
            100                 105                 110         


Asn Ile Pro Phe Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile 
        115                 120                 125             


His Pro Pro Ser Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His 
    130                 135                 140                 


Val His Gly Ile Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu 
145                 150                 155                 160 


Asp Asp Lys Pro Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp 
                165                 170                 175     


Val Ala Lys Pro Val Ile Glu Leu Tyr Lys Ser Arg Gly Val Leu His 
            180                 185                 190         


Gln Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr Thr 
        195                 200                 205             


Leu Phe Ser Asn Lys Ile Thr Pro Ile Gln Ser Lys Glu Ala Tyr 
    210                 215                 220             


<210>  4302
<211>  1694
<212>  DNA
<213>  Homosapiens

<400>  4302
gcggcggcgg cggcgagcgg tggcgctcgg ctcgggcgac cgcggcgggg gagggcgcgg     60

cgcaccgatg ggcgccactg agaagggagg ccagaagagc cggaagctgt tttccttgcg    120

gcggccgtgg aaggcgaccc ggcggctgtg gaggccacgc tcagctcgcc aggcggcgca    180

gggtgagtgt gggcgcggcc ggtcgggacc tgttaccctg aggcaggggc gcagcggcgg    240

cggggccgtc cccggcggtc tctcgggtcg cgttcccggc cctgggagcc tggatgccta    300

ggcgacgccc gaacccgacc ctcggtcgcg ggtaccggga ccgctgggga agcgcagggg    360

ctgatgtcgg cacagtctcc tttcctctag cccctgctcg ttgctttggc tctggacaca    420

gggaagccac ggtggcgcgg cgacacagcc tcactgaggt tagcttgtcc ccggccccca    480

gcacctggcc tggcgcctgc aatgcagtgc ctactggggg aatgaatcag aacccgaggc    540

tcccttcaag gtcctcccgc cctgtaccca cctcctctct acctgcctgc ggtgatttcg    600

aagctctcgc cacgataaac tatttccaag cacactcagt cctgtcctcg ccagggcctc    660

aactcacagc caatcactga ctcactccat tcattcattc cacaattttt atcgagcccc    720

tccatctgcc ttggccggag aacacgatgg gcaaagcccg gatcttggaa ctacttctag    780

agaggaagac agacattaca cacgcaaaac agagaaagcc cggtacacat tgctatgtgc    840

gcttagaggg aatcagtctg ctgacagagg aaaaaaggca ggtccccgag cttccatggc    900

aggcggactg ggaaggcctc tccgaggcat tgcaagtcag cggagacccg aggactgact    960

aggagttact ctagcgtgaa gccgagtaat agagaatagc aagtggaaag gttcccagag   1020

tgcctgaatt gagcaagggg aaagagaggg atgcagggcc tggatcgagg tctgggcaga   1080

acatgaagag gagttcggat tttattctac gtgagctggg aaaacactga agtgtgctaa   1140

gcagggaagt gacctgatct gggggctccc ggcttttctc tgtctgcagt gtccatgctc   1200

gcatctcagc ctgccggatt cctaccctcc tgccaagact agcacaaatg cagtctcctc   1260

gctgaaatct ctgtggttcc tgccacctgt aacccctcct ttagcatttc gtcacctgta   1320

gagcgtttgt cactgttcat ctggtattaa agattccaca ttctcatcca tttcatcttt   1380

gcatccccca cgaggctaag tgcagggctt ggtactgtgt agatactgct tatgaatgtg   1440

tcttgtcttg tcctttttgt ctgtttccat catctgagga tccttcctct ggggggttga   1500

catgccttat ttctaaaatg gccgaccgga tgcagggcag agccagattg caccaggacc   1560

ctgccatcga tatagtcccc ctcacccacc cccggtgttt tgaggattaa ataaattaat   1620

gaattaaacg agttagtagt tataaagtgt tagcacctat taagcattat aaaaataaat   1680

ttgaaaatga ccag                                                     1694


<210>  4303
<211>  128
<212>  PRT
<213>  Homosapiens

<400>  4303

Met Pro Arg Arg Arg Pro Asn Pro Thr Leu Gly Arg Gly Tyr Arg Asp 
1               5                   10                  15      


Arg Trp Gly Ser Ala Gly Ala Asp Val Gly Thr Val Ser Phe Pro Leu 
            20                  25                  30          


Ala Pro Ala Arg Cys Phe Gly Ser Gly His Arg Glu Ala Thr Val Ala 
        35                  40                  45              


Arg Arg His Ser Leu Thr Glu Val Ser Leu Ser Pro Ala Pro Ser Thr 
    50                  55                  60                  


Trp Pro Gly Ala Cys Asn Ala Val Pro Thr Gly Gly Met Asn Gln Asn 
65                  70                  75                  80  


Pro Arg Leu Pro Ser Arg Ser Ser Arg Pro Val Pro Thr Ser Ser Leu 
                85                  90                  95      


Pro Ala Cys Gly Asp Phe Glu Ala Leu Ala Thr Ile Asn Tyr Phe Gln 
            100                 105                 110         


Ala His Ser Val Leu Ser Ser Pro Gly Pro Gln Leu Thr Ala Asn His 
        115                 120                 125             


<210>  4304
<211>  1694
<212>  DNA
<213>  Homosapiens

<400>  4304
gcggcggcgg cggcgagcgg tggcgctcgg ctcgggcgac cgcggcgggg gagggcgcgg     60

cgcaccgatg ggcgccactg agaagggagg ccagaagagc cggaagctgt tttccttgcg    120

gcggccgtgg aaggcgaccc ggcggctgtg gaggccacgc tcagctcgcc aggcggcgca    180

gggtgagtgt gggcgcggcc ggtcgggacc tgttaccctg aggcaggggc gcagcggcgg    240

cggggccgtc cccggcggtc tctcgggtcg cgttcccggc cctgggagcc tggatgccta    300

ggcgacgccc gaacccgacc ctcggtcgcg ggtaccggga ccgctgggga agcgcagggg    360

ctgatgtcgg cacagtctcc tttcctctag cccctgctcg ttgctttggc tctggacaca    420

gggaagccac ggtggcgcgg cgacacagcc tcactgaggt tagcttgtcc ccggccccca    480

gcacctggcc tggcgcctgc aatgcagtgc ctactggggg aatgaatcag aacccgaggc    540

tcccttcaag gtcctcccgc cctgtaccca cctcctctct acctgcctgc ggtgatttcg    600

aagctctcgc cacgataaac tatttccaag cacactcagt cctgtcctcg ccagggcctc    660

aactcacagc caatcactga ctcactccat tcattcattc cacaattttt atcgagcccc    720

tccatctgcc ttggccggag aacacgatgg gcaaagcccg gatcttggaa ctacttctag    780

agaggaagac agacattaca cacgcaaaac agagaaagcc cggtacacat tgctatgtgc    840

gcttagaggg aatcagtctg ctgacagagg aaaaaaggca ggtccccgag cttccatggc    900

aggcggactg ggaaggcctc tccgaggcat tgcaagtcag cggagacccg aggactgact    960

aggagttact ctagcgtgaa gccgagtaat agagaatagc aagtggaaag gttcccagag   1020

tgcctgaatt gagcaagggg aaagagaggg atgcagggcc tggatcgagg tctgggcaga   1080

acatgaagag gagttcggat tttattctac gtgagctggg aaaacactga agtgtgctaa   1140

gcagggaagt gacctgatct gggggctccc ggcttttctc tgtctgcagt gtccatgctc   1200

gcatctcagc ctgccggatt cctaccctcc tgccaagact agcacaaatg cagtctcctc   1260

gctgaaatct ctgtggttcc tgccacctgt aacccctcct ttagcatttc gtcacctgta   1320

gagcgtttgt cactgttcat ctggtattaa agattccaca ttctcatcca tttcatcttt   1380

gcatccccca cgaggctaag tgcagggctt ggtactgtgt agatactgct tatgaatgtg   1440

tcttgtcttg tcctttttgt ctgtttccat catctgagga tccttcctct ggggggttga   1500

catgccttat ttctaaaatg gccgaccgga tgcagggcag agccagattg caccaggacc   1560

ctgccatcga tatagtcccc ctcacccacc cccggtgttt tgaggattaa ataaattaat   1620

gaattaaacg agttagtagt tataaagtgt tagcacctat taagcattat aaaaataaat   1680

ttgaaaatga ccag                                                     1694


<210>  4305
<211>  128
<212>  PRT
<213>  Homosapiens

<400>  4305

Met Pro Arg Arg Arg Pro Asn Pro Thr Leu Gly Arg Gly Tyr Arg Asp 
1               5                   10                  15      


Arg Trp Gly Ser Ala Gly Ala Asp Val Gly Thr Val Ser Phe Pro Leu 
            20                  25                  30          


Ala Pro Ala Arg Cys Phe Gly Ser Gly His Arg Glu Ala Thr Val Ala 
        35                  40                  45              


Arg Arg His Ser Leu Thr Glu Val Ser Leu Ser Pro Ala Pro Ser Thr 
    50                  55                  60                  


Trp Pro Gly Ala Cys Asn Ala Val Pro Thr Gly Gly Met Asn Gln Asn 
65                  70                  75                  80  


Pro Arg Leu Pro Ser Arg Ser Ser Arg Pro Val Pro Thr Ser Ser Leu 
                85                  90                  95      


Pro Ala Cys Gly Asp Phe Glu Ala Leu Ala Thr Ile Asn Tyr Phe Gln 
            100                 105                 110         


Ala His Ser Val Leu Ser Ser Pro Gly Pro Gln Leu Thr Ala Asn His 
        115                 120                 125             


<210>  4306
<211>  1449
<212>  DNA
<213>  Homosapiens

<400>  4306
cgttcaaagt gtttgttaat tatttattaa gataaacaat ttcttagccc acatattcat     60

gtttcacaga tagttcagga acacaggtac agtgacaaac ttctatgtaa ttcaacccaa    120

agaaatactt tatgttccaa aatcactttg tactctgaga gatattagcc ttcctcatct    180

caaattcttt aattcaatta taatttctgt agaaatctgc atatgccttc tttcttggtc    240

aggccacagc aaacttacag agagctgcaa ccccagggtt ataaggaatg ctccaacaat    300

atgaaatgac agatgcttgg ccagaaggcc acacatccca ggttacacca aggcactgag    360

agccatggta gttattgtcc ttgacaggga tgtcagcatc aacactaatg tctttcccgg    420

atgatggaga aatggaccaa cttgataagt attgatgctg agtgatacat acaaagaagt    480

ccattatatg attttcccta cttttgaata tgtttgaaaa tttccctaat agaaagtaaa    540

aagatagaat aataaaataa aaataccccc acttattacc taagttttct tttagcacaa    600

atggaaaata agtcagactc tctcatttgg ccatattgaa gctaatagtc tcagaaccac    660

tgtgtcataa cactgacatt ttgcttaaag ctctgtatca cctttaatgg cttaaaatat    720

tctagactgt attgagatca tgcaagtaga tcaaagaaag agaattacac gcaaaggaag    780

ggatagctgt actagggagt tcactggtaa cagagtcagg ggtccacagc tctgggctgg    840

gtctgtcctg aaaggcagtc tctggatagc aggatgagat ggagtgatca ctggctttgg    900

agtcagacac aatagactga gctatgttga aggacaatga caaataacac aatagatagc    960

attcattgaa ccctcactat atgccaggcc ttatgctaag ctctttatgt actttatgtt   1020

atgcaatttt aataactacc ctgtttttat tagtatttta tggatgagaa aacacaggtt   1080

tagaggttat caaatttgtc catgaccaca tgaacttgta attcccagta aatatttttg   1140

taaataaata tctgaaagtg tccaggcacg gtggctcatg cctgcaatcc cagcactttg   1200

ggaggccgag gtaggcggat cacctgaggt caagagtttg agaccagcct ggccaacatg   1260

ctgaaacccc gtctctacta aaaacacaaa agaattagct gggcatggtg gtgtgtgctt   1320

gtaatcccag ccacttggga ggctgaggca ggagaattgc ttgaacccgg gaggtgagtc   1380

aagattgcgc cactgcactc cagcctgggc aacaagagtg tgaaaactcc atctcaaaaa   1440

aaaaaaaaa                                                           1449


<210>  4307
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  4307

Met Gln Val Asp Gln Arg Lys Arg Ile Thr Arg Lys Gly Arg Asp Ser 
1               5                   10                  15      


Cys Thr Arg Glu Phe Thr Gly Asn Arg Val Arg Gly Pro Gln Leu Trp 
            20                  25                  30          


Ala Gly Ser Val Leu Lys Gly Ser Leu Trp Ile Ala Gly 
        35                  40                  45  


<210>  4308
<211>  1449
<212>  DNA
<213>  Homosapiens

<400>  4308
cgttcaaagt gtttgttaat tatttattaa gataaacaat ttcttagccc acatattcat     60

gtttcacaga tagttcagga acacaggtac agtgacaaac ttctatgtaa ttcaacccaa    120

agaaatactt tatgttccaa aatcactttg tactctgaga gatattagcc ttcctcacct    180

caaattcttt aattcaatta taatttctgt agaaatctgc atatgccttc tttcttggtc    240

aggccacagc aaacttacag agagctgcaa ccccagggtt ataaggaatg ctccaacaat    300

atgaaatgac agatgcttgg ccagaaggcc acacatccca ggttacacca aggcactgag    360

agccatggta gttattgtcc ttgacaggga tgtcagcatc aacactaatg tctttcccgg    420

atgatggaga aatggaccaa cttgataagt attgatgctg agtgatacat acaaagaagt    480

ccattatatg attttcccta cttttgaata tgtttgaaaa tttccctaat agaaagtaaa    540

aagatagaat aataaaataa aaataccccc acttattacc taagttttct tttagcacaa    600

atggaaaata agtcagactc tctcatttgg ccatattgaa gctaatagtc tcagaaccac    660

tgtgtcataa cactgacatt ttgcttaaag ctctgtatca cctttaatgg cttaaaatat    720

tctagactgt attgagatca tgcaagtaga tcaaagaaag agaattacac gcaaaggaag    780

ggatagctgt actagggagt tcactggtaa cagagtcagg ggtccacagc tctgggctgg    840

gtctgtcctg aaaggcagtc tctggatagc aggatgagat ggagtgatca ctggctttgg    900

agtcagacac aatagactga gctatgttga aggacaatga caaataacac aatagatagc    960

attcattgaa ccctcactat atgccaggcc ttatgctaag ctctttatgt actttatgtt   1020

atgcaatttt aataactacc ctgtttttat tagtatttta tggatgagaa aacacaggtt   1080

tagaggttat caaatttgtc catgaccaca tgaacttgta attcccagta aatatttttg   1140

taaataaata tctgaaagtg tccaggcacg gtggctcatg cctgcaatcc cagcactttg   1200

ggaggccgag gtaggcggat cacctgaggt caagagtttg agaccagcct ggccaacatg   1260

ctgaaacccc gtctctacta aaaacacaaa agaattagct gggcatggtg gtgtgtgctt   1320

gtaatcccag ccacttggga ggctgaggca ggagaattgc ttgaacccgg gaggtgagtc   1380

aagattgcgc cactgcactc cagcctgggc aacaagagtg tgaaaactcc atctcaaaaa   1440

aaaaaaaaa                                                           1449


<210>  4309
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  4309

Met Gln Val Asp Gln Arg Lys Arg Ile Thr Arg Lys Gly Arg Asp Ser 
1               5                   10                  15      


Cys Thr Arg Glu Phe Thr Gly Asn Arg Val Arg Gly Pro Gln Leu Trp 
            20                  25                  30          


Ala Gly Ser Val Leu Lys Gly Ser Leu Trp Ile Ala Gly 
        35                  40                  45  


<210>  4310
<211>  1789
<212>  DNA
<213>  Homosapiens

<400>  4310
tccagacgag caaggagact catggtctgg ttcttggact tccctaacag catggcccct     60

aaacgccagt ctccactccc acttcaaaag aagaaaccaa gaccacctcc tgctctggga    120

ctggaggaga catcggcctc tgcaggcttg ccgaagaagg gagaaaaaga acagcaagaa    180

gcaattgaac acattgatga agtacaaaat gaaatagaca gacttaatga acaagacagt    240

gaggagattt tgaaagtaga acagaaatat aacaaactcc gccaaccatt ttttcagaag    300

aggtcagaat tgatcgccaa aatcccaaat tttggggtaa caacatttgt caaccatcca    360

caagtgtctt cactgcttgg ggaggaggac gaagaggcac tgcattattt gactaaagtt    420

gaagtgacag aatttgaaga tattaaatca ggttacagaa tagattttta ttttgatgaa    480

aatccttact ttgaaaataa agttttctcc aaagaatttc atctgaatga gagtggtgat    540

ccatcttcaa agtccaccaa aatcaaatgg aaatctggaa aggatgtgac gaaacgttca    600

agtcaaacgc agaataaagc cagcaggaag aggcagcatg aggaaccaga gagcttcttt    660

acctggttta ctgatcattc tgatgcaggt gctgatgagt tagaagaggt catcaaagat    720

gatatttggc caaacccatt acagtattac ttggttcctg atatggatga tgaagaagga    780

ggagaagatg atgatgatga tgatgatgat ggtgatgaag gggaggaaga attagaagat    840

attgatgaag gggatgagga tgaaggtgaa gaagatgaag atgatgatga aggggaggaa    900

ggagaggagg atgaaggaga agatgactaa tagaacactg atggactcca accttccttt    960

tttaaaattt tctccagccc tgggagcaag ttgcagtctt tttttttttc tcttgtgctc   1020

agtcaccctg ttcttcagct ctcttttctc tactccatgg ttctcaactt atttgggggg   1080

aaataccttg agcagaatac aatgggaaaa gagtctctac ccttttctgt tcgaagttca   1140

tttttatccc ttcctgtctg aacaaaaact gtatggaatc aacaccaccg agctctgtgg   1200

ggaaaaagaa aaacctgctc ccttcgctct gctggaagct ggaggatgct aggcccctgt   1260

atagtagtgc atagaattct agcttttttc ctcctttctc tgtatattgg gttcagagag   1320

tacactgtgt ctctatgtag gtcaaaggga caatatggac agttagcatt taccaacaca   1380

tatctgtcta ctttctcgtg tttaaaaaaa gaaaaaaaac ttaaaaaaat ggggttatag   1440

aaggtcagca aagtgtggat ttgagatgtt tgggtgggtt aagtgggcat tttgacaaca   1500

tggcttctcc tttggcatgt ttaattgtga tatttgacag acatccttgc agtttaagat   1560

gacactttta aaataaattc cctcctaatg atgacttgag ccctgccact caatgggaga   1620

atcagcagaa cctgtaggat cttatttgga attgacattc tctattgtaa ttttgttcct   1680

gtttattttt aaattttctt tttgtttcgc tggaaaggga agatgatgct cagttttaaa   1740

cattaaaagt gtacaagttg ctttgttaca ataaaagtaa atgtataca               1789


<210>  4311
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  4311

Met Ala Pro Lys Arg Gln Ser Pro Leu Pro Leu Gln Lys Lys Lys Pro 
1               5                   10                  15      


Arg Pro Pro Pro Ala Leu Gly Leu Glu Glu Thr Ser Ala Ser Ala Gly 
            20                  25                  30          


Leu Pro Lys Lys Gly Glu Lys Glu Gln Gln Glu Ala Ile Glu His Ile 
        35                  40                  45              


Asp Glu Val Gln Asn Glu Ile Asp Arg Leu Asn Glu Gln Asp Ser Glu 
    50                  55                  60                  


Glu Ile Leu Lys Val Glu Gln Lys Tyr Asn Lys Leu Arg Gln Pro Phe 
65                  70                  75                  80  


Phe Gln Lys Arg Ser Glu Leu Ile Ala Lys Ile Pro Asn Phe Gly Val 
                85                  90                  95      


Thr Thr Phe Val Asn His Pro Gln Val Ser Ser Leu Leu Gly Glu Glu 
            100                 105                 110         


Asp Glu Glu Ala Leu His Tyr Leu Thr Lys Val Glu Val Thr Glu Phe 
        115                 120                 125             


Glu Asp Ile Lys Ser Gly Tyr Arg Ile Asp Phe Tyr Phe Asp Glu Asn 
    130                 135                 140                 


Pro Tyr Phe Glu Asn Lys Val Phe Ser Lys Glu Phe His Leu Asn Glu 
145                 150                 155                 160 


Ser Gly Asp Pro Ser Ser Lys Ser Thr Lys Ile Lys Trp Lys Ser Gly 
                165                 170                 175     


Lys Asp Val Thr Lys Arg Ser Ser Gln Thr Gln Asn Lys Ala Ser Arg 
            180                 185                 190         


Lys Arg Gln His Glu Glu Pro Glu Ser Phe Phe Thr Trp Phe Thr Asp 
        195                 200                 205             


His Ser Asp Ala Gly Ala Asp Glu Leu Glu Glu Val Ile Lys Asp Asp 
    210                 215                 220                 


Ile Trp Pro Asn Pro Leu Gln Tyr Tyr Leu Val Pro Asp Met Asp Asp 
225                 230                 235                 240 


Glu Glu Gly Gly Glu Asp Asp Asp Asp Asp Asp Asp Asp Gly Asp Glu 
                245                 250                 255     


Gly Glu Glu Glu Leu Glu Asp Ile Asp Glu Gly Asp Glu Asp Glu Gly 
            260                 265                 270         


Glu Glu Asp Glu Asp Asp Asp Glu Gly Glu Glu Gly Glu Glu Asp Glu 
        275                 280                 285             


Gly Glu Asp Asp 
    290         


<210>  4312
<211>  1789
<212>  DNA
<213>  Homosapiens

<400>  4312
tccagacgag caaggagact catggtctgg ttcttggact tccctaacag catggcccct     60

aaacgccagt ctccactccc acttcaaaag aagaaaccaa gaccacctcc tgctctggga    120

ctggaggaga catcggcctc tgcaggcttg ccgaagaagg gagaaaaaga acagcaagaa    180

gcaattgaac acattgatga agtacaaaat gaaatagaca gacttaatga acaagacagt    240

gaggagattt tgaaagtaga acagaaatat aacaaactcc gccaaccatt ttttcagaag    300

aggtcagaat tgatcgccaa aatcccaaat tttggggtaa caacatttgt caaccatcca    360

caagtgtctt cactgcttgg ggaggaggac gaagaggcac tgcattattt gactaaagtt    420

gaagtgacag aatttgaaga tattaaatca ggttacagaa tagattttta ttttgatgaa    480

aatccttact ttgaaaataa agttttctcc aaagaatttc atctgaatga gagtggtgat    540

ccatcttcaa agtccaccaa aatcaaatgg aaatctggaa aggatgtgac gaaacgttca    600

agtcaaacgc agaataaagc cagcaggaag aggcagcatg aggaaccaga gagcttcttt    660

acctggttta ctgatcattc tgatgcaggt gctgatgagt tagaagaggt catcaaagat    720

gatatttggc caaacccatt acagtattac ttggttcctg atatggatga tgaagaagga    780

ggagaagatg atgatgatga tgatgatgat ggtgatgaag gggaggaaga attagaagat    840

attgatgaag gggatgagga tgaaggtgaa gaagatgaag atgatgatga aggggaggaa    900

ggagaggagg atgaaggaga agatgactaa tagaacactg atggactcca accttccttt    960

tttaaaattt tctccagccc tgggagcaag ttgcagtctt tttttttttc tcttgtgctc   1020

agtcaccctg ttcttcagct ctcttttctc tactccatgg ttctcaactt atttgggggg   1080

aaataccttg agcagaatac aatgggaaaa gagtctctac ccttttctgt tcgaagttca   1140

tttttatccc ttcctgtctg aacaaaaact gtatggaatc aacaccaccg agctctgtgg   1200

ggaaaaagaa aaacctgctc ccttcgctct gctggaagct ggaggatgct aggcccctgt   1260

atagtagtgc atagaattct agcttttttc ctcctttctc tgtatattgg gttcagagag   1320

tacactgtgt ctctatgtag gtcaaaggga caatatggac agttagcatt taccaacaca   1380

tatctgtcta ctttctcgtg tttaaaaaaa gaaaaaaaac ttaaaaaaat ggggttatag   1440

aaggtcagca aagtgtggat ttgagatgtt tgggtgggtt aagtgggcat tttgacaaca   1500

tggcttctcc tttggcatgt ttaattgtga tatttgacag acatccttgc agtttaagat   1560

gacactttta aaataaattc cctcctaatg atgacttgag ccctgccact caatgggaga   1620

atcagcagaa cctgtaggat cttatttgga attgacattc tctattgtaa ttttgttcct   1680

gtttattttt aaattttctt tttgtttcgc tggaaaggga agatgatgct cagttttaaa   1740

cattaaaagt gtacaagttg ctttgttaca ataaaagtaa atgtataca               1789


<210>  4313
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  4313

Met Ala Pro Lys Arg Gln Ser Pro Leu Pro Leu Gln Lys Lys Lys Pro 
1               5                   10                  15      


Arg Pro Pro Pro Ala Leu Gly Leu Glu Glu Thr Ser Ala Ser Ala Gly 
            20                  25                  30          


Leu Pro Lys Lys Gly Glu Lys Glu Gln Gln Glu Ala Ile Glu His Ile 
        35                  40                  45              


Asp Glu Val Gln Asn Glu Ile Asp Arg Leu Asn Glu Gln Asp Ser Glu 
    50                  55                  60                  


Glu Ile Leu Lys Val Glu Gln Lys Tyr Asn Lys Leu Arg Gln Pro Phe 
65                  70                  75                  80  


Phe Gln Lys Arg Ser Glu Leu Ile Ala Lys Ile Pro Asn Phe Gly Val 
                85                  90                  95      


Thr Thr Phe Val Asn His Pro Gln Val Ser Ser Leu Leu Gly Glu Glu 
            100                 105                 110         


Asp Glu Glu Ala Leu His Tyr Leu Thr Lys Val Glu Val Thr Glu Phe 
        115                 120                 125             


Glu Asp Ile Lys Ser Gly Tyr Arg Ile Asp Phe Tyr Phe Asp Glu Asn 
    130                 135                 140                 


Pro Tyr Phe Glu Asn Lys Val Phe Ser Lys Glu Phe His Leu Asn Glu 
145                 150                 155                 160 


Ser Gly Asp Pro Ser Ser Lys Ser Thr Lys Ile Lys Trp Lys Ser Gly 
                165                 170                 175     


Lys Asp Val Thr Lys Arg Ser Ser Gln Thr Gln Asn Lys Ala Ser Arg 
            180                 185                 190         


Lys Arg Gln His Glu Glu Pro Glu Ser Phe Phe Thr Trp Phe Thr Asp 
        195                 200                 205             


His Ser Asp Ala Gly Ala Asp Glu Leu Glu Glu Val Ile Lys Asp Asp 
    210                 215                 220                 


Ile Trp Pro Asn Pro Leu Gln Tyr Tyr Leu Val Pro Asp Met Asp Asp 
225                 230                 235                 240 


Glu Glu Gly Gly Glu Asp Asp Asp Asp Asp Asp Asp Asp Gly Asp Glu 
                245                 250                 255     


Gly Glu Glu Glu Leu Glu Asp Ile Asp Glu Gly Asp Glu Asp Glu Gly 
            260                 265                 270         


Glu Glu Asp Glu Asp Asp Asp Glu Gly Glu Glu Gly Glu Glu Asp Glu 
        275                 280                 285             


Gly Glu Asp Asp 
    290         


<210>  4314
<211>  459
<212>  DNA
<213>  Homosapiens

<400>  4314
atggtacaaa gaacagctac agctgatgac aaaaagctgg agaagagcta caagctgccc     60

gacggccagg tcatcaccat cggcaacgaa cggttccggt gtccggaggt gctgttccag    120

tcttccttcc tgggcatgga atcctgtggc acccacaaga ccaccttcaa ctgcatcatg    180

aagtgtgatg tggacatctt caaagacctg tacgccaaca cagtgctgtc cagcggcacc    240

accatgtacc cagacatcac caacaggatg cagaaggcaa tcactgccct ggcacctagc    300

accatgaaga tcaagatcat tgcaccccga gagcgaaagt actcggtgtg gatcggcggc    360

tccatcctga cctcactgtc caccttccag cagatgtgca ctagcaagca ggagtatgac    420

aagttgggcc cctccactgt tcaccacaaa tgcttctaa                           459


<210>  4315
<211>  152
<212>  PRT
<213>  Homosapiens

<400>  4315

Met Val Gln Arg Thr Ala Thr Ala Asp Asp Lys Lys Leu Glu Lys Ser 
1               5                   10                  15      


Tyr Lys Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe 
            20                  25                  30          


Arg Cys Pro Glu Val Leu Phe Gln Ser Ser Phe Leu Gly Met Glu Ser 
        35                  40                  45              


Cys Gly Thr His Lys Thr Thr Phe Asn Cys Ile Met Lys Cys Asp Val 
    50                  55                  60                  


Asp Ile Phe Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Ser Gly Thr 
65                  70                  75                  80  


Thr Met Tyr Pro Asp Ile Thr Asn Arg Met Gln Lys Ala Ile Thr Ala 
                85                  90                  95      


Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Arg Glu Arg 
            100                 105                 110         


Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Thr Ser Leu Ser Thr 
        115                 120                 125             


Phe Gln Gln Met Cys Thr Ser Lys Gln Glu Tyr Asp Lys Leu Gly Pro 
    130                 135                 140                 


Ser Thr Val His His Lys Cys Phe 
145                 150         


<210>  4316
<211>  459
<212>  DNA
<213>  Homosapiens

<400>  4316
atggtacaaa gaacagctac agctgatgac aaaaagctgg agaagagcta caagctgccc     60

gacggccagg tcatcaccat cggcaacgaa cggttccggt gtccggaggt gctgttccag    120

tcttccttcc tgggcatgga atcctgtggc acccacaaga ccaccttcaa ctgcatcatg    180

aagtgtgatg tggacatctt caaagacctg tacgccaaca cagtgctgtc cagcggcacc    240

accatgtacc cagacatcac caacaggatg cagaaggcaa tcactgccct ggcacctagc    300

accatgaaga tcaagatcat tgcaccccga gagcgaaagt actcggtgtg gatcggcggc    360

tccatcctga cctcactgtc caccttccag cagatgtgca ctagcaagca ggagtatgac    420

aagttgggcc cctccactgt tcaccacaaa tgcttctaa                           459


<210>  4317
<211>  152
<212>  PRT
<213>  Homosapiens

<400>  4317

Met Val Gln Arg Thr Ala Thr Ala Asp Asp Lys Lys Leu Glu Lys Ser 
1               5                   10                  15      


Tyr Lys Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe 
            20                  25                  30          


Arg Cys Pro Glu Val Leu Phe Gln Ser Ser Phe Leu Gly Met Glu Ser 
        35                  40                  45              


Cys Gly Thr His Lys Thr Thr Phe Asn Cys Ile Met Lys Cys Asp Val 
    50                  55                  60                  


Asp Ile Phe Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Ser Gly Thr 
65                  70                  75                  80  


Thr Met Tyr Pro Asp Ile Thr Asn Arg Met Gln Lys Ala Ile Thr Ala 
                85                  90                  95      


Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Arg Glu Arg 
            100                 105                 110         


Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Thr Ser Leu Ser Thr 
        115                 120                 125             


Phe Gln Gln Met Cys Thr Ser Lys Gln Glu Tyr Asp Lys Leu Gly Pro 
    130                 135                 140                 


Ser Thr Val His His Lys Cys Phe 
145                 150         


<210>  4318
<211>  2523
<212>  DNA
<213>  Homosapiens

<400>  4318
agcctgaagg actgcttgcc tgtgaggagg gtcactcttg actggctgca tcaggaccat     60

gtgtgaccag cagcagatcc agtgccgcct gccgctccaa cagtgctgcg tcaagggtcc    120

ctccttctgc tcctctcaat ccccctttgc ccagagccaa gtggtggttc aagccccttg    180

tgagatgcaa attgtggact gccctgcatc atgcccagtt caagtttgcc aggtgtcaga    240

ccaggctcca tgccagtctc agaccacaca ggtgaagtgc cagtctaaga ccaagcaggt    300

gaagggccag gctcaatgtc agtctaagac cacccaggtg aagggccagg ctgcatccca    360

atctcaaact tcctctgttc aaagccaggc tccatgccaa tctgaggtgt cctacgtgca    420

gtgcgaagcg tcacaacctg ttcagacttg cttcgtagaa tgtgctccag tttgttatac    480

agaaacttgt tatgtagaat gcccagtcca gaactatgta ccctgtccag ctcctcagcc    540

tgtccagatg tatagagggc gtcctgcagt gtgccagcct cagggaagat tctccaccca    600

gtgccagtat caaggctcct atagcagttg tggcccccag tttcagtcaa gggctacctg    660

caacaactac accccccagt tccagttgag gccttcctac agcagctgtt tccctcagta    720

tcggtcccgg acttcattta gtccctgtgt gccccagtgc cagacccagg gctcctatgg    780

gagcttcact gaacagcacc gctctcggag caccagcaga tgccttcctc ctcctcggcg    840

gctgcagctt ttcccccgca gctgttcccc accaagacgt tttgagccct gctccagcag    900

ctacctgcca ctaagaccct ctgaaggttt ccctaactac tgcaccccac cccgccgctc    960

tgaacccata tataacagtc gctgtcctcg ccgccccatt tcaagctgct ctcagagacg   1020

tggccccaag tgccgaatcg agatttcctc cccgtgctgc cccaggcagg ttcccccaca   1080

gaggtgtcct gttgagattc ctcccatcag acgccgctcc cagagctgtg gcccgcagcc   1140

ctcctggggc gcctcctgcc ctgagctgag gccacacgta gagccacgtc cactcccaag   1200

cttctgtcca ccacggcgtc ttgaccagtg tccagagtca ccactgcagc gatgtccacc   1260

tcctgctcca cgtccacgtc tgcgcccaga accatgcata agtctagaac cacgcccgcg   1320

tcctctacca cgacaacttt cagaaccttg tttgtatcca gaaccacttc cagcactacg   1380

tccaacaccg cggccagttc cccttcctcg cccagggcag tgtgagattc cagagccacg   1440

tccatgcctg cagccctgtg agcacccaga gccttgtcca cgaccagagc caattcccct   1500

gccggcgccc tgcccaagcc cggagccctg cagggagact tggcgcagcc ccagcccatg   1560

ctggggccca aatccagttc catacccagg agacctaggc tgtcatgagt ctagtccaca   1620

ccgcctagac accgaagctc cctactgtgg cccatccagt tacaaccagg ggcaagagag   1680

tggtgctggc tgtgggcctg gtgatgtgtt tccagagcgg aggggtcagg atggccatgg   1740

agaccaaggc aatgcctttg ctggagtgaa aggggaagca aagagtgctt atttttaaag   1800

gaaaggtgac tgagataacc ctctctcctg ctctgaaaat gttgttcctc ctattccaca   1860

atttccagta cgctcttgtt tgaatctctc caaagatatt cagagactcc ctattacgaa   1920

ggtgatgtcc aaactccttt gcctatcatc caaagatcca cacctgggtc tcagatgcct   1980

ctccagcctc acgtgtcact cctcgcccgt acgcatcctc ggctctagcc agaccagtct   2040

ggccactggg cacagcttgg gtgttcccca ggccatactt tagatgtccc tgcctccaag   2100

cctctgctca ctcttcccca ctctgcctgg accacttctc tcctcctccc cagcttctga   2160

aatccacccc atctttcagt gcctctccct tggagccttc tttgcttgtt cccactcaca   2220

agaacctgtg ccgacttcct agaactcact gcatcccccg cactacttgg taactgcctg   2280

gtgacatctc ttgaattgtt atttcacttt gcaggcatgt cttccttatc tgcccaacta   2340

ggttgtaaac tcccaactga gtggagtcgg agaatctcta aatctcagtg tctatcctgg   2400

ggctggctgt tgcttagcaa ggcttgtggg ttggcagctt gaaccatgtt ctgtcctgat   2460

gctcaactgc aggaactgag gtgagaggag gccatgtgac aataaagatc attatgtact   2520

cac                                                                 2523


<210>  4319
<211>  579
<212>  PRT
<213>  Homosapiens

<400>  4319

Met Cys Asp Gln Gln Gln Ile Gln Cys Arg Leu Pro Leu Gln Gln Cys 
1               5                   10                  15      


Cys Val Lys Gly Pro Ser Phe Cys Ser Ser Gln Ser Pro Phe Ala Gln 
            20                  25                  30          


Ser Gln Val Val Val Gln Ala Pro Cys Glu Met Gln Ile Val Asp Cys 
        35                  40                  45              


Pro Ala Ser Cys Pro Val Gln Val Cys Gln Val Ser Asp Gln Ala Pro 
    50                  55                  60                  


Cys Gln Ser Gln Thr Thr Gln Val Lys Cys Gln Ser Lys Thr Lys Gln 
65                  70                  75                  80  


Val Lys Gly Gln Ala Gln Cys Gln Ser Lys Thr Thr Gln Val Lys Gly 
                85                  90                  95      


Gln Ala Ala Ser Gln Ser Gln Thr Ser Ser Val Gln Ser Gln Ala Pro 
            100                 105                 110         


Cys Gln Ser Glu Val Ser Tyr Val Gln Cys Glu Ala Ser Gln Pro Val 
        115                 120                 125             


Gln Thr Cys Phe Val Glu Cys Ala Pro Val Cys Tyr Thr Glu Thr Cys 
    130                 135                 140                 


Tyr Val Glu Cys Pro Val Gln Asn Tyr Val Pro Cys Pro Ala Pro Gln 
145                 150                 155                 160 


Pro Val Gln Met Tyr Arg Gly Arg Pro Ala Val Cys Gln Pro Gln Gly 
                165                 170                 175     


Arg Phe Ser Thr Gln Cys Gln Tyr Gln Gly Ser Tyr Ser Ser Cys Gly 
            180                 185                 190         


Pro Gln Phe Gln Ser Arg Ala Thr Cys Asn Asn Tyr Thr Pro Gln Phe 
        195                 200                 205             


Gln Leu Arg Pro Ser Tyr Ser Ser Cys Phe Pro Gln Tyr Arg Ser Arg 
    210                 215                 220                 


Thr Ser Phe Ser Pro Cys Val Pro Gln Cys Gln Thr Gln Gly Ser Tyr 
225                 230                 235                 240 


Gly Ser Phe Thr Glu Gln His Arg Ser Arg Ser Thr Ser Arg Cys Leu 
                245                 250                 255     


Pro Pro Pro Arg Arg Leu Gln Leu Phe Pro Arg Ser Cys Ser Pro Pro 
            260                 265                 270         


Arg Arg Phe Glu Pro Cys Ser Ser Ser Tyr Leu Pro Leu Arg Pro Ser 
        275                 280                 285             


Glu Gly Phe Pro Asn Tyr Cys Thr Pro Pro Arg Arg Ser Glu Pro Ile 
    290                 295                 300                 


Tyr Asn Ser Arg Cys Pro Arg Arg Pro Ile Ser Ser Cys Ser Gln Arg 
305                 310                 315                 320 


Arg Gly Pro Lys Cys Arg Ile Glu Ile Ser Ser Pro Cys Cys Pro Arg 
                325                 330                 335     


Gln Val Pro Pro Gln Arg Cys Pro Val Glu Ile Pro Pro Ile Arg Arg 
            340                 345                 350         


Arg Ser Gln Ser Cys Gly Pro Gln Pro Ser Trp Gly Ala Ser Cys Pro 
        355                 360                 365             


Glu Leu Arg Pro His Val Glu Pro Arg Pro Leu Pro Ser Phe Cys Pro 
    370                 375                 380                 


Pro Arg Arg Leu Asp Gln Cys Pro Glu Ser Pro Leu Gln Arg Cys Pro 
385                 390                 395                 400 


Pro Pro Ala Pro Arg Pro Arg Leu Arg Pro Glu Pro Cys Ile Ser Leu 
                405                 410                 415     


Glu Pro Arg Pro Arg Pro Leu Pro Arg Gln Leu Ser Glu Pro Cys Leu 
            420                 425                 430         


Tyr Pro Glu Pro Leu Pro Ala Leu Arg Pro Thr Pro Arg Pro Val Pro 
        435                 440                 445             


Leu Pro Arg Pro Gly Gln Cys Glu Ile Pro Glu Pro Arg Pro Cys Leu 
    450                 455                 460                 


Gln Pro Cys Glu His Pro Glu Pro Cys Pro Arg Pro Glu Pro Ile Pro 
465                 470                 475                 480 


Leu Pro Ala Pro Cys Pro Ser Pro Glu Pro Cys Arg Glu Thr Trp Arg 
                485                 490                 495     


Ser Pro Ser Pro Cys Trp Gly Pro Asn Pro Val Pro Tyr Pro Gly Asp 
            500                 505                 510         


Leu Gly Cys His Glu Ser Ser Pro His Arg Leu Asp Thr Glu Ala Pro 
        515                 520                 525             


Tyr Cys Gly Pro Ser Ser Tyr Asn Gln Gly Gln Glu Ser Gly Ala Gly 
    530                 535                 540                 


Cys Gly Pro Gly Asp Val Phe Pro Glu Arg Arg Gly Gln Asp Gly His 
545                 550                 555                 560 


Gly Asp Gln Gly Asn Ala Phe Ala Gly Val Lys Gly Glu Ala Lys Ser 
                565                 570                 575     


Ala Tyr Phe 
            


<210>  4320
<211>  790
<212>  DNA
<213>  Homosapiens

<400>  4320
ctgtagtaca catccttgat ggcaccaagt agcaaacgtg ctgtggagac tagatctcac     60

tctcaaatct gtcctgggat gcaagtgcct ctacgaatgt ggtgcagaag ctacaaatgt    120

ggtgcagaag acagcttcaa agaggaaagg aatatagatc ctgagactcc agcaggatgt    180

cttatcaaca gcagcagtgc aagcagccct gccagccacc tcctgtgtgc cccacgccaa    240

agtgcccaga gccatgtcca cccccgaagt gccctgagcc ctgcccatca ccaaagtgtc    300

cacagccctg cccacctcag cagtgccagc agaaatatcc tcctgtgaca ccttccccac    360

cctgccagcc aaagtgtcca cccaagagca agtaacagct tcaggattca tcaggagcat    420

gagaggataa ggataattgg ctcacctcgt tccacagctc cacttgcatc ttctcaccaa    480

agccttccat ggatgcacag ggagcttctt tctccttaac ctgtggcctg cctgtgatga    540

tctgtgacag caaaagattc cctttctgag gctgccatac tgccactgtc caggtggagc    600

taagaaaagg aagtcctcag ctgtgccagc tcccagagct tcggaagaaa gagcagcagc    660

tctctccctg ggaaccatca gacaattctg ttgatgtgtt ctgtgtctgt ctgtcacctg    720

gtcatgagct tctaccacct ttgcaattgt catttatctt tcactccctg aataaagtat    780

ctatgcatat                                                           790


<210>  4321
<211>  72
<212>  PRT
<213>  Homosapiens

<400>  4321

Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Ser Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Tyr Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210>  4322
<211>  762
<212>  DNA
<213>  Homosapiens

<400>  4322
aaactcctgg tacttgagca ctgatctgct ttggagaacc tgattctgag actccagcag     60

gatgtcttat caacagcagc agtgcaagca gccctgccag ccacctcctg tgtgccccac    120

gccaaagtgc ccagagccat gtccaccccc gaagtgccct gagccctgcc caccaccaaa    180

gtgtccacag ccctgcccac ctcagcagtg ccagcaaaaa tgtcctcctg tgacaccttc    240

cccaccctgc cagccaaagt gtccacccaa gagcaagtaa cagcttcaga attcatcagg    300

agcatgaaag gataaggata attggctcac cttgttccac agcttcacct gcatcttctc    360

atcaaagcct accatggata cacagttagc ttctttcctc ttagccagtg atctgcccat    420

gatgatccct gatagcaaaa ggtttccttt ctgaggctgc catattgcca ctgtccaggt    480

ggagactgag aaaggaagtc ctcagcagtg tcagttccca gagctttgga agaaggacca    540

gcagctctgt ccctgggaac catcaaaaaa tgctgttgat gttttctgtg tctgtctgtc    600

acctgggcat gggcttctaa cacctgtgca attgtcactt ttctttcact ccctgaataa    660

aatatctttg catacgtaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                       762


<210>  4323
<211>  72
<212>  PRT
<213>  Homosapiens

<400>  4323

Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Pro Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Cys Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210>  4324
<211>  657
<212>  DNA
<213>  Homosapiens

<400>  4324
actcctggta cctaagcacc gatctgcctt ggagaacctg attctgagac tccagcagga     60

tgtcttatca acagcagcag tgcaagcagc cctgccagcc acctcctgtg tgccccgcgc    120

caaagtgccc agagccatgt ccacccccga agtgccctga gccctgccca ccatcaaagt    180

gtccacagtc ctgcccacct cagcagtgcc agcagaaatg tcctcctgtg acaccttccc    240

caccctgcca gccaaagtgt ccacccaaga gcaagtaaca gcttcaggat tcatcaggag    300

catgaaagga taaggataat tggctcacct cgttccacag ctccacctgc atcttctcat    360

caaagccatc cagggataca cagggagctt ctttcctctt agcctgtgat cggcctgtga    420

tgatctctga tagcaaaagg ttttcttttt gaggctgcca tactgccact gtcgaggtgg    480

agactgagca aaggaagtcc tgggctgtgc cagctcccag agcttcagaa gaaagagcag    540

ctctctccct gggaaccatt agagaattct gttgatgttt tctgtgtctg tctgtcccct    600

gggcatgagc ttccaccacc tgtgcagttg tcactttcct ttcactccct gaataaa       657


<210>  4325
<211>  72
<212>  PRT
<213>  Homosapiens

<400>  4325

Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Ala Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Pro Ser Lys Cys Pro Gln Ser Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Cys Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210>  4326
<211>  678
<212>  DNA
<213>  Homosapiens

<400>  4326
agaggttctc agcctcatga ctcctaaact cctggtactt gagcaccgat ctgcttcgga     60

gaacctgatt ctgagactcc agcaggatgt cttatcaaca gtagcaatgt aagcagccct    120

gccagccacc tcctgtgtgc cgcctgccaa agcgtccaga gccatgtcca cccctgaagt    180

gccctgagcc ctgcccacca ccaaagtgtc cacagccctg cccacctcag cagtgccagc    240

agaaatatcc tctggtgaca ccttccccac cctgccagcc aaagtgtcca cccaagagca    300

agtaacagct tcggaattca tcaggaccac gaaaggatag ggataattgg ctcacctcgt    360

tccacagctc cacctgcatc ttctcatcaa agccatccag ggatacacag ggagcttctt    420

tccccttagc ctgtgatctg cccatgatga tccccgacag caaaatgttt cctttctgag    480

gctgccatgc tgccactgtc caggtggaga ctgagcaaag gaagtcctca gctgtaccgg    540

cctttcagag cttctctttg ggtgccatca aagaattatt ttgatgtctt ctgtctctgt    600

ctgtcacctg gcatgagctt ctactatctg tgcaattgtc acttttcttt cactccctga    660

ataaagtagc tatgccta                                                  678


<210>  4327
<211>  580
<212>  DNA
<213>  Homosapiens

<400>  4327
gaagactctg attctctgag actgaggaga gatgtcttac cagcagcagc agtgcaagca     60

gccctgccag ccacctcctg tgtgccccac gccaaagtgc ccagagccat gtccaccccc    120

gaagtgccct gagccttacc tgcctcctcc ttgtccacct gagcattgcc cacctccacc    180

atgccaggat aaatgccctc ctgtgcaacc atacccaccc tgccagcaga agtatccacc    240

caagagcaag taacatcact agaattcatc aggaccatga aacaacaaga tccagtggct    300

cttcttactc ccaggactcc atcatcttcc cttcagctgt agtgggaggc tgcatcttcc    360

ctaacctctg tctggcttga gcgttgacag agaaaaggct tagttctgaa aaccgatatg    420

ttgttggaag atgagcagcc agatcactgc ctaatctcgc tttgctgtct gtgatgtaga    480

tggtggttcc tatcctgaga gcaagtgtgt ttattctttt gcttctcccc aataaagcac    540

atgtttcatg gtcaagccca aaaaaaaaaa aaaaaaaaaa                          580


<210>  4328
<211>  73
<212>  PRT
<213>  Homosapiens

<400>  4328

Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Tyr Leu Pro Pro Pro Cys Pro Pro Glu His Cys Pro Pro 
        35                  40                  45              


Pro Pro Cys Gln Asp Lys Cys Pro Pro Val Gln Pro Tyr Pro Pro Cys 
    50                  55                  60                  


Gln Gln Lys Tyr Pro Pro Lys Ser Lys 
65                  70              


<210>  4329
<211>  1175
<212>  DNA
<213>  Homosapiens

<400>  4329
atggaactat tttacttaat ccttagtaac cttgtacaga ggcagcagcg ggaaacgctg     60

ggcggaggag aggggagggg gccacaggct gcccggacgg cgcaagcgca tcgcggcgag    120

gcgcgcacgc aacccgcaat ccggggaccc gcgggcggct cgtcccttcc cccaccccca    180

gccgccgccg ccgcccgcgc ttcgcaacaa agccggctgc ggagccatgg tccacggcgc    240

ccgcccgcga ccccgccgcc ccgcatggta gccggaacgt ctctccctta ccagccttcg    300

cttcctggtg cccagctctt aggaccgtgt gtgactctgg ccttctaccg agacaacaga    360

gaaacgcaca gcaactcgca tggaggaatc ggcgaaatgg ctccgaccgc ggcgctaggg    420

ggcggggcca gcgagcggtg ttgaaagcag caggggccta gaagacatta aaccgatacc    480

acagaaatac aaaggatcat tagagactat tatgaacaac tatatgccaa caaattggaa    540

accaaatgga aatggataaa ttcctgaaca gatacaactt accaaaattg gaccaagaag    600

aaatagaaaa cctgaaaaga ccaactatga gtaatgagat taaatcagta atatagagtc    660

tcccatcaaa gaaaagtcca ggccctgatg gcttcactgc tgaattctac tgaacagtta    720

aagaagaact cataccagtt ctcaaactca tcctgtgagg gcagcattac cctgatacca    780

aaactagata tggacacaag aaaaaaaatc tataggccag tatccctgat gaacatagat    840

gcaagaatcc tcaacaagac caggtgtggt ggttcatgcc tgtaatccca gcactttggg    900

aggccaaggc aggtggatca cctgaggtca ggaatttgag accagcctgg ccaacatggc    960

aaaaccctgt ctgtactaaa aatacaaaaa ttagccgggc aaggtggcgt gtgcctgtaa   1020

tcctagctac ttgggaggct gaggcaggag aattgcttga acctggaggg aggaggggca   1080

gaagttgcag cgagctcaga tcgtcccact gcactccagc ctgggtgaca gagtgagact   1140

ccatctcaaa ataagtaaat aaataaagag actca                              1175


<210>  4330
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  4330

Met Glu Leu Phe Tyr Leu Ile Leu Ser Asn Leu Val Gln Arg Gln Gln 
1               5                   10                  15      


Arg Glu Thr Leu Gly Gly Gly Glu Gly Arg Gly Pro Gln Ala Ala Arg 
            20                  25                  30          


Thr Ala Gln Ala His Arg Gly Glu Ala Arg Thr Gln Pro Ala Ile Arg 
        35                  40                  45              


Gly Pro Ala Gly Gly Ser Ser Leu Pro Pro Pro Pro Ala Ala Ala Ala 
    50                  55                  60                  


Ala Arg Ala Ser Gln Gln Ser Arg Leu Arg Ser His Gly Pro Arg Arg 
65                  70                  75                  80  


Pro Pro Ala Thr Pro Pro Pro Arg Met Val Ala Gly Thr Ser Leu Pro 
                85                  90                  95      


Tyr Gln Pro Ser Leu Pro Gly Ala Gln Leu Leu Gly Pro Cys Val Thr 
            100                 105                 110         


Leu Ala Phe Tyr Arg Asp Asn Arg Glu Thr His Ser Asn Ser His Gly 
        115                 120                 125             


Gly Ile Gly Glu Met Ala Pro Thr Ala Ala Leu Gly Gly Gly Ala Ser 
    130                 135                 140                 


Glu Arg Cys 
145         


<210>  4331
<211>  1175
<212>  DNA
<213>  Homosapiens

<400>  4331
atggaactat tttacttaat ccttagtaac cttgtacaga ggcagcagcg ggaaacgctg     60

ggcggaggag aggggagggg gccacaggct gcccggacgg cgcaagcgca tcgcggcgag    120

gcgcgcacgc aacccgcaat ccggggaccc gcgggcggct cgtcccttcc cccaccccca    180

gccgccgccg ccgcccgcgc ttcgcaacaa agccggctgc ggagccatgg tccacgccgc    240

ccgcccgcga ccccgccgcc ccgcatggta gccggaacgt ctctccctta ccagccttcg    300

cttcctggtg cccagctctt aggaccgtgt gtgactctgg ccttctaccg agacaacaga    360

gaaacgcaca gcaactcgca tggaggaatc ggcgaaatgg ctccgaccgc ggcgctaggg    420

ggcggggcca gcgagcggtg ttgaaagcag caggggccta gaagacatta aaccgatacc    480

acagaaatac aaaggatcat tagagactat tatgaacaac tatatgccaa caaattggaa    540

accaaatgga aatggataaa ttcctgaaca gatacaactt accaaaattg gaccaagaag    600

aaatagaaaa cctgaaaaga ccaactatga gtaatgagat taaatcagta atatagagtc    660

tcccatcaaa gaaaagtcca ggccctgatg gcttcactgc tgaattctac tgaacagtta    720

aagaagaact cataccagtt ctcaaactca tcctgtgagg gcagcattac cctgatacca    780

aaactagata tggacacaag aaaaaaaatc tataggccag tatccctgat gaacatagat    840

gcaagaatcc tcaacaagac caggtgtggt ggttcatgcc tgtaatccca gcactttggg    900

aggccaaggc aggtggatca cctgaggtca ggaatttgag accagcctgg ccaacatggc    960

aaaaccctgt ctgtactaaa aatacaaaaa ttagccgggc aaggtggcgt gtgcctgtaa   1020

tcctagctac ttgggaggct gaggcaggag aattgcttga acctggaggg aggaggggca   1080

gaagttgcag cgagctcaga tcgtcccact gcactccagc ctgggtgaca gagtgagact   1140

ccatctcaaa ataagtaaat aaataaagag actca                              1175


<210>  4332
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  4332

Met Glu Leu Phe Tyr Leu Ile Leu Ser Asn Leu Val Gln Arg Gln Gln 
1               5                   10                  15      


Arg Glu Thr Leu Gly Gly Gly Glu Gly Arg Gly Pro Gln Ala Ala Arg 
            20                  25                  30          


Thr Ala Gln Ala His Arg Gly Glu Ala Arg Thr Gln Pro Ala Ile Arg 
        35                  40                  45              


Gly Pro Ala Gly Gly Ser Ser Leu Pro Pro Pro Pro Ala Ala Ala Ala 
    50                  55                  60                  


Ala Arg Ala Ser Gln Gln Ser Arg Leu Arg Ser His Gly Pro Arg Arg 
65                  70                  75                  80  


Pro Pro Ala Thr Pro Pro Pro Arg Met Val Ala Gly Thr Ser Leu Pro 
                85                  90                  95      


Tyr Gln Pro Ser Leu Pro Gly Ala Gln Leu Leu Gly Pro Cys Val Thr 
            100                 105                 110         


Leu Ala Phe Tyr Arg Asp Asn Arg Glu Thr His Ser Asn Ser His Gly 
        115                 120                 125             


Gly Ile Gly Glu Met Ala Pro Thr Ala Ala Leu Gly Gly Gly Ala Ser 
    130                 135                 140                 


Glu Arg Cys 
145         


<210>  4333
<211>  279
<212>  DNA
<213>  Homosapiens

<400>  4333
atgaaaaaag gtttaatggt ctggaaagaa gatcaaacca gccacaacat tcccttaagt     60

gaagctgcaa acgctgatgc aggagatata gcaagttatc cagaagattt ggctaaggtt    120

gttgatgaat gtggctacac tgaacaacag attttcagtg tagatgaaac agcgttacac    180

tggaaaaaga tgccatctaa aactttcata gctagagagg agaaggcaat gtctggattc    240

aaagctccaa aggacaacct gactcttgat aggggataa                           279


<210>  4334
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  4334

Met Lys Lys Gly Leu Met Val Trp Lys Glu Asp Gln Thr Ser His Asn 
1               5                   10                  15      


Ile Pro Leu Ser Glu Ala Ala Asn Ala Asp Ala Gly Asp Ile Ala Ser 
            20                  25                  30          


Tyr Pro Glu Asp Leu Ala Lys Val Val Asp Glu Cys Gly Tyr Thr Glu 
        35                  40                  45              


Gln Gln Ile Phe Ser Val Asp Glu Thr Ala Leu His Trp Lys Lys Met 
    50                  55                  60                  


Pro Ser Lys Thr Phe Ile Ala Arg Glu Glu Lys Ala Met Ser Gly Phe 
65                  70                  75                  80  


Lys Ala Pro Lys Asp Asn Leu Thr Leu Asp Arg Gly 
                85                  90          


<210>  4335
<211>  339
<212>  DNA
<213>  Homosapiens

<400>  4335
atggagtggg aaggtagttt tcccttggag tgggctgccc cgcggctagg ttctcctccg     60

tccgaccggc cccagctaaa ctccgcatca ttcagctggt ggatggcctg ctggcgtctg    120

ccggtgccgg tcggtgtgcc cttccaccgg tatgttcctc tcgacgtcca gccgcttgtg    180

tgttcctctg gtgtgtttca ctcaatgtcc acccactcgt gtttctaccc actagggcac    240

cggggattta taggcacagg atgggggcgt ggagggccag agtcgtcttg gaaaatggaa    300

gatttgggca cgagaacaga aatgcccgtc ctcacctag                           339


<210>  4336
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  4336

Met Glu Trp Glu Gly Ser Phe Pro Leu Glu Trp Ala Ala Pro Arg Leu 
1               5                   10                  15      


Gly Ser Pro Pro Ser Asp Arg Pro Gln Leu Asn Ser Ala Ser Phe Ser 
            20                  25                  30          


Trp Trp Met Ala Cys Trp Arg Leu Pro Val Pro Val Gly Val Pro Phe 
        35                  40                  45              


His Arg Tyr Val Pro Leu Asp Val Gln Pro Leu Val Cys Ser Ser Gly 
    50                  55                  60                  


Val Phe His Ser Met Ser Thr His Ser Cys Phe Tyr Pro Leu Gly His 
65                  70                  75                  80  


Arg Gly Phe Ile Gly Thr Gly Trp Gly Arg Gly Gly Pro Glu Ser Ser 
                85                  90                  95      


Trp Lys Met Glu Asp Leu Gly Thr Arg Thr Glu Met Pro Val Leu Thr 
            100                 105                 110         


<210>  4337
<211>  583
<212>  DNA
<213>  Homosapiens

<400>  4337
ttcgggaggc gggggaggaa agcggccggc gagcgctggc tgacattttc ctgcccggaa     60

ggatgcatgg cccggggtct cctgcacctg agggtgggcg ggaggcggcc ccgcgggttg    120

tgttgctgga aaaaggggtc tcgatccaga ccccaagaga gggttcttgg gtctacttca    180

gggaagaatt ggaggcgagt cacagagcgc agtgaaggaa gcaagtttat tggaatctac    240

tccgttagag agtgcaagtc ctcagactgc aggaggagga actcccgtcc ttcggtagtg    300

tcactactta gaggcagctg tgaggagctg tgattaatcg tggaatgtgc tgatgtgccc    360

actaaaggta ggggctgttg gtgcactaat gaccattaat ccttcaacct aagcctgcgc    420

attgacgtta tctctgagta gagggctggg ccgggctcgg tggccacgtc tgtaatccca    480

gcactgtggg aggccggaca ggagtctccc ttgagcccag gagttcgaga ccagcctggg    540

caacatactg agatgccatc tatttaaaaa aaaaaaaaaa aaa                      583


<210>  4338
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  4338

Met Ala Arg Gly Leu Leu His Leu Arg Val Gly Gly Arg Arg Pro Arg 
1               5                   10                  15      


Gly Leu Cys Cys Trp Lys Lys Gly Ser Arg Ser Arg Pro Gln Glu Arg 
            20                  25                  30          


Val Leu Gly Ser Thr Ser Gly Lys Asn Trp Arg Arg Val Thr Glu Arg 
        35                  40                  45              


Ser Glu Gly Ser Lys Phe Ile Gly Ile Tyr Ser Val Arg Glu Cys Lys 
    50                  55                  60                  


Ser Ser Asp Cys Arg Arg Arg Asn Ser Arg Pro Ser Val Val Ser Leu 
65                  70                  75                  80  


Leu Arg Gly Ser Cys Glu Glu Leu 
                85              


<210>  4339
<211>  1379
<212>  DNA
<213>  Homosapiens

<400>  4339
gcgagcgctg gctgacattt tcctgcccgg aaggatgcat ggcccggggt ctcctgcacc     60

tgagggtggg cgggaggcgg ccccgcgggt tgtgttgctg gaaaaagggg tctcgatcca    120

gaccccaaga gagggttctt gggtctactt cagggaagaa ttggaggcga gtcacagagc    180

gcagtgaagg aagcaagttt attggaatct actccgttag agagtgcaag tcctcagact    240

gcaggaggag gaactcccgt ccttcggtag tgtcactact tagaggcagc tgtgaggagc    300

tgtgattaat cgtggaatgt gctgatgtgc ccactaaaga tgcctggtaa gcagtggctc    360

ctctaacaag tgggcagctt ggaactggga acgagagagc caccgaaaca gaatgaggga    420

gacaaagaag tgggcatcac ccttaactcc acaagggctt cccaagggcg ctgtaccgta    480

cgcaggccca ggacgaactt tatttctcgc cccagcatcg ctgtccttgt cggtgagacc    540

ctggctttag ggcagacagg accacgtttc ataagttcat gctgtcccag cagaggaata    600

acgccagaaa gtgttccagt acaaccagag aaagagagtc catgagaaat ctgcccttgt    660

gaagttggaa tcccctcaac ctcaccccgc tgacttgaat gaagcgactg agacgggcta    720

tgatggagca gatccggttg ctcgaccttc tcccttgcac caacacatgt agttaatagt    780

tactggacat gcatattcag tgggttccag gtaccaaact tgtattgaat ggtatgtgcc    840

agacaccgtc ttgagatctg gagaataaaa aaataaaaaa ataaaaacga gacatccaga    900

gcacagtagc cttgcggtct tcctggaact agagaaaatt cagcccttct gctccttggg    960

aagctatgtt tgggaaaaaa aaaaaaagag agagagagag actccaaaga gtttgttatt   1020

aaatttaagt tcaaactagg tgtatatagt acaaaagttc ttaccatgca tttaatctta   1080

aaatgtgctg atatctagaa ccctaaaacc ctgcactttt ttattgcctc ttacattatt   1140

attttggtca tgtatgaaat atatcaggca tctctcggta caggtgaaat gctacatgtt   1200

ctaaactaag gaataagtgc attattataa tgtcttcctt ggccaaactg tataaatccc   1260

cccctccgcc cgccccggcc aacatccctt ccctgctttt ttttttcttt ctttcctagt   1320

gcttaccttc acctaaaatg tcctatattt ttactttttt tttctggtta ttttctttc    1379


<210>  4340
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  4340

Met Ala Arg Gly Leu Leu His Leu Arg Val Gly Gly Arg Arg Pro Arg 
1               5                   10                  15      


Gly Leu Cys Cys Trp Lys Lys Gly Ser Arg Ser Arg Pro Gln Glu Arg 
            20                  25                  30          


Val Leu Gly Ser Thr Ser Gly Lys Asn Trp Arg Arg Val Thr Glu Arg 
        35                  40                  45              


Ser Glu Gly Ser Lys Phe Ile Gly Ile Tyr Ser Val Arg Glu Cys Lys 
    50                  55                  60                  


Ser Ser Asp Cys Arg Arg Arg Asn Ser Arg Pro Ser Val Val Ser Leu 
65                  70                  75                  80  


Leu Arg Gly Ser Cys Glu Glu Leu 
                85              


<210>  4341
<211>  1580
<212>  DNA
<213>  Homosapiens

<400>  4341
tttggggtca agtttgaggc agttgtaact gtactgagtt tagttttgct aataatggta     60

ttctacgtgt gtcagcctcg tgtggacttc tgtaatgact aatggatatg tttatatcct    120

gagcatttgc tgtaggaatt ttaaatgcaa tcccaaaact caagattacc ttatttggag    180

aaatattcgt gttactatgt ttaaaattta atagaaccat attttacctt tcactttggg    240

actcgcacag gatgtttgca gctcttgata tacaggaact agaacgtgtc ttttaagagc    300

atgcggtttt ataattacgt ggaagtatgc tacgcaaggg aaaaaagcct cttgctagtg    360

ttaagggtct tcataaacag aaaccgcaag gaacctggga tctgacagct gttggaggaa    420

tgcctgtgag gaaggaggag gaacagaaga atgctttgat gtcttaaatg gtacatccaa    480

acttaagtga aatagagctg tgaggacatt ttggggagaa gtgacctaga taagcactga    540

ctgttgcatt catctctctt cttgctgatt gtgatgattt cctgtgccat agccattcaa    600

agtctgccaa aaaaggcctt gcctcctgga tggcattttt gaacccaccc tgggccagag    660

gggagcccac ttctttgaag acagaaacac aggactggca acatttacca taagctgact    720

gagcagccat tgggccttga gtgaacattg gtggtagcca ggcagtactt gtctcagtac    780

ttgcctcagg cctggggtgt cggtgaccac agggagagca tccatctgct tgaggaaagg    840

agaacaaaga aaataaaggg cttaatcttg cacttgattg ccagctcagc catagtagaa    900

tacagcacca agtaaattcc taaggatcct gattccaggt cctggctccc agatgacatt    960

ttaggacttg tcttgggctt agggggagct cgtcatactg aagggaaaaa cacaagcctg   1020

gctggatttg ccaccagctg aataaagagt gcttgggcct tgagtgaaca ttggcaatag   1080

ccaaggagtg gtcaccatgg accttaggca agaaacccgg tgccgtgctg gctttggatc   1140

tgacccagca taatctcact ggtattttac ttcttgtcca tttacttttt agtttatcat   1200

acacaccatg tttactagta ctaaaactgt cttaaaatat tgcaattttg accctttttc   1260

taattgacct ttatgttttt acaagcacat tttattacat atgaatgaga ctttactatg   1320

ttatatgtaa ctcttaattc tgtaaataat agattgctta tctgaaatat agctgatatt   1380

tgtttcttaa ttatttggct attccctata tgttatactc tactaaagat catgggattt   1440

agattcagaa aacttacttc ctagctctta ttatttctgt gatcttgcaa aagaaaacaa   1500

aaatgaacca ttgttttttt atctgtaaca ggaaatgtac ttcacaggat tgtaatgaga   1560

attaaattag ataatataca                                               1580


<210>  4342
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  4342

Met Leu Arg Lys Gly Lys Lys Pro Leu Ala Ser Val Lys Gly Leu His 
1               5                   10                  15      


Lys Gln Lys Pro Gln Gly Thr Trp Asp Leu Thr Ala Val Gly Gly Met 
            20                  25                  30          


Pro Val Arg Lys Glu Glu Glu Gln Lys Asn Ala Leu Met Ser 
        35                  40                  45      


<210>  4343
<211>  1580
<212>  DNA
<213>  Homosapiens

<400>  4343
tttggggtca agtttgaggc agttgtaact gtactgagtt tagttttgct aataatggta     60

ttctacgtgt gtcagcctcg tgtggacttc tgtaatgact aatggatatg tttatatcct    120

gagcatttgc tgtaggaatt ttaaatgcaa tcccaaaact caagattacc ttatttggag    180

aaatattcgt gttactatgt ttaaaattta atagaaccat attttacctt tcactttggg    240

actcgcacag gatgtttgca gctcttgata tacaggaact agaacgtgtc ttttaagagc    300

atgcggtttt ataattacgt ggaagtatgc tacgcaaggg aaaaaagcct cttgctagtg    360

ttaagggtct tcataaacag aaaccgcaag gaacctggga tctgacagct gttggaggaa    420

tgcctgtgag gaaggaggag gaacagaaga atgctttgat gtcttaaatg gtacatccaa    480

acttaagtga aatagagctg tgaggacatt ttggggagaa gtgacctaga taagcactga    540

ctgttgcatt catctctctt cttgctgatt gtgatgattt cctgtgccat agccattcaa    600

agtctgccaa aaaaggcctt gcctcctgga tggcattttt gaacccaccc tgggccagag    660

gggagcccac ttctttgaag acagaaacac aggactggca acatttacca taagctgact    720

gagcagccat tgggccttga gtgaacattg gtggtagcca ggcagtactt gtctcagtac    780

ttgcctcagg cctggggtgt cggtgaccac agggagagca tccatctgct tgaggaaagg    840

agaacaaaga aaataaaggg cttaatcttg cacttgattg ccagctcagc catagtagaa    900

tacagcacca agtaaattcc taaggatcct gattccaggt cctggctccc agatgacatt    960

ttaggacttg tcttgggctt agggggagct cgtcatactg aagggaaaaa cacaagcctg   1020

gctggatttg ccaccagctg aataaagagt gcttgggcct tgagtgaaca ttggcaatag   1080

ccaaggagtg gtcaccatgg accttaggca agaaacccgg tgccgtgctg gctttggatc   1140

tgacccagca taatctcact ggtattttac ttcttgtcca tttacttttt agtttatcat   1200

acacaccatg tttactagta ctaaaactgt cttaaaatat tgcaattttg accctttttc   1260

taattgacct ttatgttttt acaagcacat tttattacat atgaatgaga ctttactatg   1320

ttatatgtaa ctcttaattc tgtaaataat agattgctta tctgaaatat agctgatatt   1380

tgtttcttaa ttatttggct attccctata tgttatactc tactaaagat catgggattt   1440

agattcagaa aacttacttc ctagctctta ttatttctgt gatcttgcaa aagaaaacaa   1500

aaatgaacca ttgttttttt atctgtaaca ggaaatgtac ttcacaggat tgtaatgaga   1560

attaaattag ataatataca                                               1580


<210>  4344
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  4344

Met Leu Arg Lys Gly Lys Lys Pro Leu Ala Ser Val Lys Gly Leu His 
1               5                   10                  15      


Lys Gln Lys Pro Gln Gly Thr Trp Asp Leu Thr Ala Val Gly Gly Met 
            20                  25                  30          


Pro Val Arg Lys Glu Glu Glu Gln Lys Asn Ala Leu Met Ser 
        35                  40                  45      


<210>  4345
<211>  4581
<212>  DNA
<213>  Homosapiens

<400>  4345
gcacttttac cggccgggcc ttagagcgca gcctgtagcc gggcgccatc tttgacgctg     60

gcagtcttgg ttttctgcta gtgctgctgc tgctgggagg acgacggacg gcagcggcca    120

agcaagaaga aagacgtggc agcaagcggg agtcggggat agtgtcatcg gttcggtgat    180

gctttttagg atttggggat attccctgcc caaaaaattc ctggaaaatt gactagtatt    240

aagtgcataa tagattggaa ctcagtgaag acacagacgt tcctgttgag agcaaccagc    300

taatgattac agtttaaaga caatttctgt gatcaagttg tcatttggaa gattaaaccc    360

atttcacgag gacttggagc ctggtccttg ctttgaggaa gcagtggctt gtttcaagaa    420

gccacttctg atctaagaat ctacccagca tgcctaatca aggagaagac tgctattttt    480

ttttctattc tacatgtacc aaaggtgaca gctgcccatt ccgtcactgt gaagctgcac    540

taggcaatga aactgtttgc acattatggc aagaagggcg ctgttttcga cgggtgtgca    600

ggtttcggca catggagatt gataaaaaac gcagtgaaat tccttgttat tgggaaaatc    660

agccaacagg atgtcaaaaa ttaaactgcg ttttccatca caatagagga cgatatgttg    720

atggcctttt cctacctccg agcaaaagtg tgttgcccac tgtgcctgag tcaccagaag    780

aggaagtgaa ggctagccaa ctttcagttc agcagaacaa attgtctgtc cagtccaata    840

cttcccctca gctgcggagc gttatgaaag tagaaagttc cgaaaatgtt cctagcccca    900

agcatccacc agttgtaatt aatgctgcag atgatgatga agatgatgat gatcagtttt    960

ctgaggaagg tgatgaaacc aaaacaccta ccctgcaacc aactcctgaa gttcacaatg   1020

gattacgagt gacttctgtc cggaaacctg cagtcaatat aaagcaaggt gaatgtttgc   1080

attttggaat aaaaactctt gaggaaatta agtcaaagaa aatgaaggaa aaatctgagg   1140

agcaaggtga gggttcttca ggagtttcca gtcttttact ccaccctgag cctgttccag   1200

gtcctgaaaa agaaaatgtc aggactgtgg tgaggacagt aactctctcc accaaacaag   1260

gagaagaacc cttggttaga ttgggcctta ctgagacact ggggaaacga aaattttcga   1320

caggcggtga cagtgatcct ccattaaagc gtagcctggc acagaggcta gggaagaaag   1380

ttgaagctcc agaaactaac actgacgaaa caccaaagaa agctcaagtt tccaagtctc   1440

ttaaggagcg attaggcatg tcagctgatc caaataatga ggacgcaaca gataaagtta   1500

ataaagttgg tgagatccat gtgaagacat tagaagaaat gcttcttgaa agagccagtc   1560

agaaacatgg ggaatcgcaa actaaactca agacagaagg accttcaaaa actgatgatt   1620

ctacttcagg agcaagaagc tcctccacta tccgtatcaa aaccttctct gaggtcctgg   1680

ctgaagaaga acataggcag caggaagcag agagacaaaa aagcaaaaag gatacaactt   1740

gcatcaagct aaagactgat agtgaaatta aaaaaacagt agttttgcca cccattgttg   1800

ccagcaaagg acaatcagag gagcctgcag gtaaaacaaa gtccatgcag gaggtgcaca   1860

tgaagacggt ggaagaaatt aaactggaga aggcactgag ggtgcagcag agctctgaga   1920

gcagcaccag ctccccgtct caacatgagg ccactccagg ggcaaggttg ctgctgcgaa   1980

tcaccaaaag aacatggagg aaagaagaga agaaacttca ggaaggaaat gaagttgatt   2040

ttctgagccg tgttagaatg gaagctacag aggcttcagt tgagaccaca ggagttgaca   2100

tcactaaaat tcaagtcaag agatgtgaga tcatgagaga gacgcgcatg cagaaacagc   2160

aggagaggga aaaatcagtc ttgacacctc ttcagggaga tgtagcctct tgcaataccc   2220

aagtggcaga gaaaccagtg ctcactgctg tgccaggaat cacatggcac ctgaccaagc   2280

agcttcccac aaagtcatcc cagaaggtgg aggtagaaac ctcagggatt gcagactcat   2340

tattgaatgt gaaatggtca gcacagacct tggaaaaaag gggtgaagct aaacccacag   2400

tgaacgtgaa gcaatctgtg gttaaagttg tgtcatcccc caaattggcc ccaaaacgta   2460

aggcagtgga gatgcaccct gctgtcactg ccgctgtgaa gccactcagc tccagcagcg   2520

tcctacagga acccccagcc aaaaaggcag ctgtggatgc tgttgtcctg cttgactctg   2580

aggacaaatc agtcactgtg cctgaagcag aaaatcctag agacagtctt gtgctgcctc   2640

caacccagtc ctcttcagat tcctcacccc cggaggtgtc tggcccttcc tcatcccaaa   2700

tgagcatgaa aactcgccga ctcagctctg cctcaacagg aaagccccca ctctctgtgg   2760

aggatgattt tgagaaacta acatgggaga tttcaggagg caaattggaa gctgagattg   2820

acctggatcc tgggaaagat gaagatgacc ttccgcttga gctatgagaa atgattgata   2880

gctgaaggtg gtagtgagga cactttaaaa aaaaatcgcc aaaaaactgg acttagtttc   2940

atctattgta acatttacct gagatgatca tttctttagt ctagaatttg ccccaaatca   3000

gaagtatacc tctgaattat ctgtatgtgt cctggattcc ttggggtcag atttttaaag   3060

ttactttata accattttgt ccatttgatg ccattgttta tcatcttttg agaaaaaagt   3120

tctgtcatac ccttctctcc acaaaaaaga gactgagggg gagatcaagt gaaagggtgc   3180

aagcaaactt agtgactcct tgaggtgttt gtcagttttg gcttttttct cctttgttgt   3240

attctttatg tattgtctta atgtacttaa tattacctga gtttgaaatg gatgaagaca   3300

gctgctacca ttaagggcca aattttatgc taccactaaa caaaaatacc cactcagtct   3360

gtgttaaatt gtatgtcttt ttaaaggtat ttagagattc aactaagctt taaagagggc   3420

tgagcaactc aggaagcctg taatgtgggc ataactcttt ggacctgatc ttgatgcttc   3480

tgctgctctg ttggcctctg aagagcaata tctaatttat tattactgta attttttaaa   3540

aggctttaaa gtgcctcagg ggtcccctga aactaatttt ctatttctgg gattccctgg   3600

attcattata tgagatggtg acatgattag aggaattctt ttttagtatg aaaattgttc   3660

cttttcttct tcagtacttg cctccttgct ggcattgaat taacacaggg acaaaatttg   3720

gttaattttt tatttctaat tctcccaaca aacccctgtt gcccagtatt tatgtggtgg   3780

cctttaacca cctgagggaa aaaatgagct tattcaagct gccaatattt atctatgggc   3840

tgtagcagta cactgaattg tactgtgcca gggatattga gatgctctgg gggtgtattg   3900

tatacctgcc agttttcttc atttctgaat tgggttttct cttcttgatg ttggtttcct   3960

tcatatcacc tcaaggttta gatttgtgaa ggaataagca tgatggaaat aatagtcttg   4020

aaaggagata tgttgtatat aatcaggagg aagaggaagg caggacttac tcattttgat   4080

attttgctgt aggtggccag ttttgtttct catagggaaa tctgacccac ctgtcatgtt   4140

ggctcctaag gaactgctgt tgtaagcggc tcatcaagag ttgaacttca agtagccttg   4200

ttgggaatat ggaaaaggaa gaaagccaca ggactgccca ttcagtcttg ttaagattgg   4260

gatgattctg cacaagcaaa aatgactcga aatttatgta tcgacacacc tctaccaatc   4320

catcttcagc tgactgaatg ttgtatgata gcccttctcc aaagcagggg tagaatgttc   4380

aggtttcacc acggattttc tacttatttc gcttttggaa tcagcttaca gattccaggt   4440

cccttttgta tatattcttt attcttttgc ttttttaaaa aataaacttg tattagtcaa   4500

tgtttcgtgt tccgcattat ttgaaccatt tgcccttaca gaaagagaaa tacttgtttg   4560

tgttttaaat aaaactgatg t                                             4581


<210>  4346
<211>  805
<212>  PRT
<213>  Homosapiens

<400>  4346

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Val Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Thr Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320 


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350         


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495     


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510         


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525             


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540                 


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560 


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575     


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590         


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605             


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620                 


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640 


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655     


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670         


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685             


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700                 


Val Val Leu Leu Asp Ser Glu Asp Lys Ser Val Thr Val Pro Glu Ala 
705                 710                 715                 720 


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Pro Thr Gln Ser Ser Ser 
                725                 730                 735     


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750         


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765             


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780                 


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800 


Leu Pro Leu Glu Leu 
                805 


<210>  4347
<211>  1442
<212>  DNA
<213>  Homosapiens

<400>  4347
ttgttttgtt tttgaggaga taactaaccc ttgctgtctc cagtctgaca aaggttattt     60

gaatggactt aatctcccag tagttgggag atgttttaaa aacacatgct gtgtttgaat    120

tgtggctgag aggttttctt ggcaatgtga ggaggaaaat tttttctgcc tcattattat    180

taattcatgg attgagtgtt ggttcgacct acaggcataa tagattggaa ctcagtgaag    240

acacagacgt tcctgttgag agcaaccagc taatgattac agtttaaaga caatttctgt    300

gatcaagttg tcatttggaa gattaaaccc atttcacgag gacttggagc ctggtccttg    360

ctttgaggaa gcagtggctt gtttcaagaa gccacttctg atctaagaat ctacccagca    420

tgcctaatca aggagaagac tgctattttt ttttctattc tacatgtacc aaaggtgaca    480

gctgcccatt ccgtcactgt gaagctgcac taggcaatga aactgtttgc acattatggc    540

aagaagggcg ctgttttcga cgggtgtgca ggtttcggca catggagatt gataaaaaac    600

gcagtgaaat tccttgttat tgggaaaatc agccaacagg atgtcaaaaa ttaaactgcg    660

ttttccatca caatagagga cgatatgttg atggcctttt cctacctccg agcaaaagtg    720

tgttgcccac tgtgcctgag tcaccagaag aggaagtgaa ggctagccaa ctttcagttc    780

agcagaacaa attgtctgtc cagtccaata cttcccctca gctgcggagc gttatgaaag    840

tagaaagttc cgaaaatgtt cctagcccca agcatccacc agttgtaatt aatgctgcag    900

atgatgatga agatgatgat gatcagtttt ctgaggaagg tgatgaaacc aaaacaccta    960

ccctgcaacc aactcctgaa gttcacaatg gattacgagt gacttctgtc cggaaacctg   1020

cagtcaatat aaagcaaggt gaatgtttgc attttggaat aaaaactctt gaggaaatta   1080

agtcaaagaa aatgaaggaa aaatctgagg agcaaggaac tgctgttgta agcggctcat   1140

caagagttga acttcaagta gccttgttgg gaatatggaa aaggaagaaa gccacaggac   1200

tgcccattca gtcttgttaa gattgggatg attctgcaca agcaaaaatg actcgaaatt   1260

tatgtatcga cacacctcta ccaatccatc ttcagctgac tgaatgttgt atgatagccc   1320

ttctccaaag caggggtaga atgttcaggt ttcaccacgg attttctact tatttcgctt   1380

ttggaatcag cttacagatt ccaggtccct tttgtatata ttctttattc ttttgctttt   1440

tt                                                                  1442


<210>  4348
<211>  266
<212>  PRT
<213>  Homosapiens

<400>  4348

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Val Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Thr Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Glu Glu Gln Gly Thr Ala Val Val Ser Gly Ser 
225                 230                 235                 240 


Ser Arg Val Glu Leu Gln Val Ala Leu Leu Gly Ile Trp Lys Arg Lys 
                245                 250                 255     


Lys Ala Thr Gly Leu Pro Ile Gln Ser Cys 
            260                 265     


<210>  4349
<211>  5086
<212>  DNA
<213>  Homosapiens

<400>  4349
gctagtgctg ctgctgctgg gaggacgacg gacggcagcg gccaagcaag aagaaagacg     60

tggcagcaag cgggagtcgg ggatagtgtc atcggttcgg gtcccactac tttggagctt    120

gtctcaaact ccacatacag aaagccacca accttattcc ggtatcctac acccattccc    180

caccctcatt acactcccac ccctggccct cagcatggga gtcaagagca acagggacac    240

ttccgtactc cttgtaggat tggtgaaacc gtaatgaaga acacccctaa actcccataa    300

ttggtgcgga ttcctgtggg gaaggcctat actgttgaca tcttccaggc catctcaagg    360

ttctggacct tgagaaggag gctgtggaac tagagatagt gatgcttttt aggatttggg    420

gatattccct gcccaaaaaa ttcctggaaa attgactagt attaagtcta tggaagatgg    480

attttttttc atgatccttt gactctcaag ttcatcttta aatgaactct tttttttgtt    540

ttgtttttga ggagataact aacccttgct gtctccagtc tgacaaaggt tatttgaatg    600

gacttaatct cccagtagtt gggagatgtt ttaaaaacac atgctgtgtt tgaattgtgg    660

ctgagaggtt ttcttggcaa tgtgaggagg aaaatttttt ctgcctcatt attattaatt    720

catggattga gtgttggttc gacctacagg cataatagat tggaactcag tgaagacaca    780

gacgttcctg ttgagagcaa ccagctaatg attacagttt aaagacaatt tctgtgatca    840

agttgtcatt tggaagatta aacccatttc acgaggactt ggagcctggt ccttgctttg    900

aggaagcagt ggcttgtttc aagaagccac ttctgatcta agaatctacc cagcatgcct    960

aatcaaggag aagactgcta tttttttttc tattctacat gtaccaaagg tgacagctgc   1020

ccattccgtc actgtgaagc tgcactaggc aatgaaactg tttgcacatt atggcaagaa   1080

gggcgctgtt ttcgacgggt gtgcaggttt cggcacatgg agattgataa aaaacgcagt   1140

gaaattcctt gttattggga aaatcagcca acaggatgtc aaaaattaaa ctgcgttttc   1200

catcacaata gaggacgata tgttgatggc cttttcctac ctccgagcaa aagtgtgttg   1260

cccactgtgc ctgagtcacc agaagaggaa gtgaaggcta gccaactttc agttcagcag   1320

aacaaattgt ctgtccagtc caatacttcc cctcagctgc ggagcgttat gaaagtagaa   1380

agttccgaaa atgttcctag ccccaagcat ccaccagttg taattaatgc tgcagatgat   1440

gatgaagatg atgatgatca gttttctgag gaaggtgatg aaaccaaaac acctaccctg   1500

caaccaactc ctgaagttca caatggatta cgagtgactt ctgtccggaa acctgcagtc   1560

aatataaagc aaggtgaatg tttgcatttt ggaataaaaa ctcttgagga aattaagtca   1620

aagaaaatga aggaaaaatc tgaggagcaa ggtgagggtt cttcaggagt ttccagtctt   1680

ttactccacc ctgagcctgt tccaggtcct gaaaaagaaa atgtcaggac tgtggtgagg   1740

acagtaactc tctccaccaa acaaggagaa gaacccttgg ttagattggg ccttactgag   1800

acactgggga aacgaaaatt ttcgacaggc ggtgacagtg atcctccatt aaagcgtagc   1860

ctggcacaga ggctagggaa gaaagttgaa gctccagaaa ctaacactga cgaaacacca   1920

aagaaagctc aagtttccaa gtctcttaag gagcgattag gcatgtcagc tgatccaaat   1980

aatgaggacg caacagataa agttaataaa gttggtgaga tccatgtgaa gacattagaa   2040

gaaatgcttc ttgaaagagc cagtcagaaa catggggaat cgcaaactaa actcaagaca   2100

gaaggacctt caaaaactga tgattctact tcaggagcaa gaagctcctc cactatccgt   2160

atcaaaacct tctctgaggt cctggctgaa gaagaacata ggcagcagga agcagagaga   2220

caaaaaagca aaaaggatac aacttgcatc aagctaaaga ctgatagtga aattaaaaaa   2280

acagtagttt tgccacccat tgttgccagc aaaggacaat cagaggagcc tgcaggtaaa   2340

acaaagtcca tgcaggaggt gcacatgaag acggtggaag aaattaaact ggagaaggca   2400

ctgagggtgc agcagagctc tgagagcagc accagctccc cgtctcaaca tgaggccact   2460

ccaggggcaa ggttgctgct gcgaatcacc aaaagaacat ggaggaaaga agagaagaaa   2520

cttcaggaag gaaatgaagt tgattttctg agccgtgtta gaatggaagc tacagaggct   2580

tcagttgaga ccacaggagt tgacatcact aaaattcaag tcaagagatg tgagatcatg   2640

agagagacgc gcatgcagaa acagcaggag agggaaaaat cagtcttgac acctcttcag   2700

ggagatgtag cctcttgcaa tacccaagtg gcagagaaac cagtgctcac tgctgtgcca   2760

ggaatcacat ggcacctgac caagcagctt cccacaaagt catcccagaa ggtggaggta   2820

gaaacctcag ggattgcaga ctcattattg aatgtgaaat ggtcagcaca gaccttggaa   2880

aaaaggggtg aagctaaacc cacagtgaac gtgaagcaat ctgtggttaa agttgtgtca   2940

tcccccaaat tggccccaaa acgtaaggca gtggagatgc accctgctgt cactgccgct   3000

gtgaagccac tcagctccag cagcgtccta caggaacccc cagccaaaaa ggcagctgtg   3060

gatgctgttg tcctgcttga ctctgaggac aaatcagtca ctgtgcctga agcagaaaat   3120

cctagagaca gtcttgtgct gcctccaacc cagtcctctt cagattcctc acccccggag   3180

gtgtctggcc cttcctcatc ccaaatgagc atgaaaactc gccgactcag ctctgcctca   3240

acaggaaagc ccccactctc tgtggaggat gattttgaga aactaacatg ggagatttca   3300

ggaggcaaat tggaagctga gattgacctg gatcctggga aagatgaaga tgaccttccg   3360

cttgagctat gagaaatgat tgatagctga aggtggtagt gaggacactt taaaaaaaaa   3420

tcgccaaaaa actggactta gtttcatcta ttgtaacatt tacctgagat gatcatttct   3480

ttagtctaga atttgcccca aatcagaagt atacctctga attatctgta tgtgtcctgg   3540

attccttggg gtcagatttt taaagttact ttataaccat tttgtccatt tgatgccatt   3600

gtttatcatc ttttgagaaa aaagttctgt catacccttc tctccacaaa aaagagactg   3660

agggggagat caagtgaaag ggtgcaagca aacttagtga ctccttgagg tgtttgtcag   3720

ttttggcttt tttctccttt gttgtattct ttatgtattg tcttaatgta cttaatatta   3780

cctgagtttg aaatggatga agacagctgc taccattaag ggccaaattt tatgctacca   3840

ctaaacaaaa atacccactc agtctgtgtt aaattgtatg tctttttaaa ggtatttaga   3900

gattcaacta agctttaaag agggctgagc aactcaggaa gcctgtaatg tgggcataac   3960

tctttggacc tgatcttgat gcttctgctg ctctgttggc ctctgaagag caatatctaa   4020

tttattatta ctgtaatttt ttaaaaggct ttaaagtgcc tcaggggtcc cctgaaacta   4080

attttctatt tctgggattc cctggattca ttatatgaga tggtgacatg attagaggaa   4140

ttctttttta gtatgaaaat tgttcctttt cttcttcagt acttgcctcc ttgctggcat   4200

tgaattaaca cagggacaaa atttggttaa ttttttattt ctaattctcc caacaaaccc   4260

ctgttgccca gtatttatgt ggtggccttt aaccacctga gggaaaaaat gagcttattc   4320

aagctgccaa tatttatcta tgggctgtag cagtacactg aattgtactg tgccagggat   4380

attgagatgc tctgggggtg tattgtatac ctgccagttt tcttcatttc tgaattgggt   4440

tttctcttct tgatgttggt ttccttcata tcacctcaag gtttagattt gtgaaggaat   4500

aagcatgatg gaaataatag tcttgaaagg agatatgttg tatataatca ggaggaagag   4560

gaaggcagga cttactcatt ttgatatttt gctgtaggtg gccagttttg tttctcatag   4620

ggaaatctga cccacctgtc atgttggctc ctaaggaact gctgttgtaa gcggctcatc   4680

aagagttgaa cttcaagtag ccttgttggg aatatggaaa aggaagaaag ccacaggact   4740

gcccattcag tcttgttaag attgggatga ttctgcacaa gcaaaaatga ctcgaaattt   4800

atgtatcgac acacctctac caatccatct tcagctgact gaatgttgta tgatagccct   4860

tctccaaagc aggggtagaa tgttcaggtt tcaccacgga ttttctactt atttcgcttt   4920

tggaatcagc ttacagattc caggtccctt ttgtatatat tctttattct tttgcttttt   4980

taaaaaataa acttgtatta gtcaatgttt cgtgttccgc attatttgaa ccatttgccc   5040

ttacagaaag agaaatactt gtttgtgttt taaataaaac tgatgt                  5086


<210>  4350
<211>  805
<212>  PRT
<213>  Homosapiens

<400>  4350

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Val Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Thr Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320 


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350         


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495     


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510         


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525             


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540                 


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560 


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575     


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590         


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605             


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620                 


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640 


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655     


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670         


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685             


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700                 


Val Val Leu Leu Asp Ser Glu Asp Lys Ser Val Thr Val Pro Glu Ala 
705                 710                 715                 720 


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Pro Thr Gln Ser Ser Ser 
                725                 730                 735     


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750         


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765             


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780                 


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800 


Leu Pro Leu Glu Leu 
                805 


<210>  4351
<211>  4338
<212>  DNA
<213>  Homosapiens

<400>  4351
ctccacctcc cagattcaag caattctcct gcctcagcct cctgagtagc tgggattaca     60

ggattacagt ttaaagacaa tttctgtgat caagttgtca tttggaagat taaacccatt    120

tcacgaggac ttggagcctg gtccttgctt tgaggaagca gtggcttgtt tcaagaagcc    180

acttctgatc taagaatcta cccagcatgc ctaatcaagg agaagactgc tatttttttt    240

tctattctac atgtaccaaa ggtgacagct gcccattccg tcactgtgaa gctgcactag    300

gcaatgaaac tgtttgcaca ttatggcaag aagggcgctg ttttcgacgg gtgtgcaggt    360

ttcggcacat ggagattgat aaaaaacgca gtgaaattcc ttgttattgg gaaaatcagc    420

caacaggatg tcaaaaatta aactgcgttt tccatcacaa tagaggacga tatgttgatg    480

gccttttcct acctccgagc aaaagtgtgt tgcccactgt gcctgagtca ccagaagagg    540

aagtgaaggc tagccaactt tcagttcagc agaacaaatt gtctgtccag tccaatactt    600

cccctcagct gcggagcgtt atgaaagtag aaagttccga aaatgttcct agccccaagc    660

atccaccagt tgtaattaat gctgcagatg atgatgaaga tgatgatgat cagttttctg    720

aggaaggtga tgaaaccaaa acacctaccc tgcaaccaac tcctgaagtt cacaatggat    780

tacgagtgac ttctgtccgg aaacctgcag tcaatataaa gcaaggtgaa tgtttgcatt    840

ttggaataaa aactcttgag gaaattaagt caaagaaaat gaaggaaaaa tctgaggagc    900

aaggtgaggg ttcttcagga gtttccagtc ttttactcca ccctgagcct gttccaggtc    960

ctgaaaaaga aaatgtcagg actgtggtga ggacagtaac tctctccacc aaacaaggag   1020

aagaaccctt ggttagattg ggccttactg agacactggg gaaacgaaaa ttttcgacag   1080

gcggtgacag tgatcctcca ttaaagcgta gcctggcaca gaggctaggg aagaaagttg   1140

aagctccaga aactaacact gacgaaacac caaagaaagc tcaagtttcc aagtctctta   1200

aggagcgatt aggcatgtca gctgatccaa ataatgagga cgcaacagat aaagttaata   1260

aagttggtga gatccatgtg aagacattag aagaaatgct tcttgaaaga gccagtcaga   1320

aacatgggga atcgcaaact aaactcaaga cagaaggacc ttcaaaaact gatgattcta   1380

cttcaggagc aagaagctcc tccactatcc gtatcaaaac cttctctgag gtcctggctg   1440

aagaagaaca taggcagcag gaagcagaga gacaaaaaag caaaaaggat acaacttgca   1500

tcaagctaaa gactgatagt gaaattaaaa aaacagtagt tttgccaccc attgttgcca   1560

gcaaaggaca atcagaggag cctgcaggta aaacaaagtc catgcaggag gtgcacatga   1620

agacggtgga agaaattaaa ctggagaagg cactgagggt gcagcagagc tctgagagca   1680

gcaccagctc cccgtctcaa catgaggcca ctccaggggc aaggttgctg ctgcgaatca   1740

ccaaaagaac atggaggaaa gaagagaaga aacttcagga aggaaatgaa gttgattttc   1800

tgagccgtgt tagaatggaa gctacagagg cttcagttga gaccacagga gttgacatca   1860

ctaaaattca agtcaagaga tgtgagatca tgagagagac gcgcatgcag aaacagcagg   1920

agagggaaaa atcagtcttg acacctcttc agggagatgt agcctcttgc aatacccaag   1980

tggcagagaa accagtgctc actgctgtgc caggaatcac atggcacctg accaagcagc   2040

ttcccacaaa gtcatcccag aaggtggagg tagaaacctc agggattgca gactcattat   2100

tgaatgtgaa atggtcagca cagaccttgg aaaaaagggg tgaagctaaa cccacagtga   2160

acgtgaagca atctgtggtt aaagttgtgt catcccccaa attggcccca aaacgtaagg   2220

cagtggagat gcaccctgct gtcactgccg ctgtgaagcc actcagctcc agcagcgtcc   2280

tacaggaacc cccagccaaa aaggcagctg tggatgctgt tgtcctgctt gactctgagg   2340

acaaatcagt cactgtgcct gaagcagaaa atcctagaga cagtcttgtg ctgcctccaa   2400

cccagtcctc ttcagattcc tcacccccgg aggtgtctgg cccttcctca tcccaaatga   2460

gcatgaaaac tcgccgactc agctctgcct caacaggaaa gcccccactc tctgtggagg   2520

atgattttga gaaactaaca tgggagattt caggaggcaa attggaagct gagattgacc   2580

tggatcctgg gaaagatgaa gatgaccttc cgcttgagct atgagaaatg attgatagct   2640

gaaggtggta gtgaggacac tttaaaaaaa aatcgccaaa aaactggact tagtttcatc   2700

tattgtaaca tttacctgag atgatcattt ctttagtcta gaatttgccc caaatcagaa   2760

gtatacctct gaattatctg tatgtgtcct ggattccttg gggtcagatt tttaaagtta   2820

ctttataacc attttgtcca tttgatgcca ttgtttatca tcttttgaga aaaaagttct   2880

gtcataccct tctctccaca aaaaagagac tgagggggag atcaagtgaa agggtgcaag   2940

caaacttagt gactccttga ggtgtttgtc agttttggct tttttctcct ttgttgtatt   3000

ctttatgtat tgtcttaatg tacttaatat tacctgagtt tgaaatggat gaagacagct   3060

gctaccatta agggccaaat tttatgctac cactaaacaa aaatacccac tcagtctgtg   3120

ttaaattgta tgtcttttta aaggtattta gagattcaac taagctttaa agagggctga   3180

gcaactcagg aagcctgtaa tgtgggcata actctttgga cctgatcttg atgcttctgc   3240

tgctctgttg gcctctgaag agcaatatct aatttattat tactgtaatt ttttaaaagg   3300

ctttaaagtg cctcaggggt cccctgaaac taattttcta tttctgggat tccctggatt   3360

cattatatga gatggtgaca tgattagagg aattcttttt tagtatgaaa attgttcctt   3420

ttcttcttca gtacttgcct ccttgctggc attgaattaa cacagggaca aaatttggtt   3480

aattttttat ttctaattct cccaacaaac ccctgttgcc cagtatttat gtggtggcct   3540

ttaaccacct gagggaaaaa atgagcttat tcaagctgcc aatatttatc tatgggctgt   3600

agcagtacac tgaattgtac tgtgccaggg atattgagat gctctggggg tgtattgtat   3660

acctgccagt tttcttcatt tctgaattgg gttttctctt cttgatgttg gtttccttca   3720

tatcacctca aggtttagat ttgtgaagga ataagcatga tggaaataat agtcttgaaa   3780

ggagatatgt tgtatataat caggaggaag aggaaggcag gacttactca ttttgatatt   3840

ttgctgtagg tggccagttt tgtttctcat agggaaatct gacccacctg tcatgttggc   3900

tcctaaggaa ctgctgttgt aagcggctca tcaagagttg aacttcaagt agccttgttg   3960

ggaatatgga aaaggaagaa agccacagga ctgcccattc agtcttgtta agattgggat   4020

gattctgcac aagcaaaaat gactcgaaat ttatgtatcg acacacctct accaatccat   4080

cttcagctga ctgaatgttg tatgatagcc cttctccaaa gcaggggtag aatgttcagg   4140

tttcaccacg gattttctac ttatttcgct tttggaatca gcttacagat tccaggtccc   4200

ttttgtatat attctttatt cttttgcttt tttaaaaaat aaacttgtat tagtcaatgt   4260

ttcgtgttcc gcattatttg aaccatttgc ccttacagaa agagaaatac ttgtttgtgt   4320

tttaaataaa actgatgt                                                 4338


<210>  4352
<211>  805
<212>  PRT
<213>  Homosapiens

<400>  4352

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Val Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Thr Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320 


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350         


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495     


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510         


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525             


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540                 


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560 


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575     


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590         


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605             


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620                 


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640 


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655     


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670         


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685             


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700                 


Val Val Leu Leu Asp Ser Glu Asp Lys Ser Val Thr Val Pro Glu Ala 
705                 710                 715                 720 


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Pro Thr Gln Ser Ser Ser 
                725                 730                 735     


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750         


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765             


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780                 


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800 


Leu Pro Leu Glu Leu 
                805 


<210>  4353
<211>  4368
<212>  DNA
<213>  Homosapiens

<400>  4353
gcaacctcca cctcccagat tcaagcaatt ctcctgcctc agcctcctga gtagctggga     60

ttacaggcgc gtactaccat gcctggctaa tgattacagt ttaaagacaa tttctgtgat    120

caagttgtca tttggaagat taaacccatt tcacgaggac ttggagcctg gtccttgctt    180

tgaggaagca gtggcttgtt tcaagaagcc acttctgatc taagaatcta cccagcatgc    240

ctaatcaagg agaagactgc tatttttttt tctattctac atgtaccaaa ggtgacagct    300

gcccattccg tcactgtgaa gctgcactag gcaatgaaac tgtttgcaca ttatggcaag    360

aagggcgctg ttttcgacgg gtgtgcaggt ttcggcacat ggagattgat aaaaaacgca    420

gtgaaattcc ttgttattgg gaaaatcagc caacaggatg tcaaaaatta aactgcgttt    480

tccatcacaa tagaggacga tatgttgatg gccttttcct acctccgagc aaaagtgtgt    540

tgcccactgt gcctgagtca ccagaagagg aagtgaaggc tagccaactt tcagttcagc    600

agaacaaatt gtctgtccag tccaatactt cccctcagct gcggagcgtt atgaaagtag    660

aaagttccga aaatgttcct agccccaagc atccaccagt tgtaattaat gctgcagatg    720

atgatgaaga tgatgatgat cagttttctg aggaaggtga tgaaaccaaa acacctaccc    780

tgcaaccaac tcctgaagtt cacaatggat tacgagtgac ttctgtccgg aaacctgcag    840

tcaatataaa gcaaggtgaa tgtttgcatt ttggaataaa aactcttgag gaaattaagt    900

caaagaaaat gaaggaaaaa tctgaggagc aaggtgaggg ttcttcagga gtttccagtc    960

ttttactcca ccctgagcct gttccaggtc ctgaaaaaga aaatgtcagg actgtggtga   1020

ggacagtaac tctctccacc aaacaaggag aagaaccctt ggttagattg ggccttactg   1080

agacactggg gaaacgaaaa ttttcgacag gcggtgacag tgatcctcca ttaaagcgta   1140

gcctggcaca gaggctaggg aagaaagttg aagctccaga aactaacact gacgaaacac   1200

caaagaaagc tcaagtttcc aagtctctta aggagcgatt aggcatgtca gctgatccaa   1260

ataatgagga cgcaacagat aaagttaata aagttggtga gatccatgtg aagacattag   1320

aagaaatgct tcttgaaaga gccagtcaga aacatgggga atcgcaaact aaactcaaga   1380

cagaaggacc ttcaaaaact gatgattcta cttcaggagc aagaagctcc tccactatcc   1440

gtatcaaaac cttctctgag gtcctggctg aagaagaaca taggcagcag gaagcagaga   1500

gacaaaaaag caaaaaggat acaacttgca tcaagctaaa gactgatagt gaaattaaaa   1560

aaacagtagt tttgccaccc attgttgcca gcaaaggaca atcagaggag cctgcaggta   1620

aaacaaagtc catgcaggag gtgcacatga agacggtgga agaaattaaa ctggagaagg   1680

cactgagggt gcagcagagc tctgagagca gcaccagctc cccgtctcaa catgaggcca   1740

ctccaggggc aaggttgctg ctgcgaatca ccaaaagaac atggaggaaa gaagagaaga   1800

aacttcagga aggaaatgaa gttgattttc tgagccgtgt tagaatggaa gctacagagg   1860

cttcagttga gaccacagga gttgacatca ctaaaattca agtcaagaga tgtgagatca   1920

tgagagagac gcgcatgcag aaacagcagg agagggaaaa atcagtcttg acacctcttc   1980

agggagatgt agcctcttgc aatacccaag tggcagagaa accagtgctc actgctgtgc   2040

caggaatcac atggcacctg accaagcagc ttcccacaaa gtcatcccag aaggtggagg   2100

tagaaacctc agggattgca gactcattat tgaatgtgaa atggtcagca cagaccttgg   2160

aaaaaagggg tgaagctaaa cccacagtga acgtgaagca atctgtggtt aaagttgtgt   2220

catcccccaa attggcccca aaacgtaagg cagtggagat gcaccctgct gtcactgccg   2280

ctgtgaagcc actcagctcc agcagcgtcc tacaggaacc cccagccaaa aaggcagctg   2340

tggatgctgt tgtcctgctt gactctgagg acaaatcagt cactgtgcct gaagcagaaa   2400

atcctagaga cagtcttgtg ctgcctccaa cccagtcctc ttcagattcc tcacccccgg   2460

aggtgtctgg cccttcctca tcccaaatga gcatgaaaac tcgccgactc agctctgcct   2520

caacaggaaa gcccccactc tctgtggagg atgattttga gaaactaaca tgggagattt   2580

caggaggcaa attggaagct gagattgacc tggatcctgg gaaagatgaa gatgaccttc   2640

cgcttgagct atgagaaatg attgatagct gaaggtggta gtgaggacac tttaaaaaaa   2700

aatcgccaaa aaactggact tagtttcatc tattgtaaca tttacctgag atgatcattt   2760

ctttagtcta gaatttgccc caaatcagaa gtatacctct gaattatctg tatgtgtcct   2820

ggattccttg gggtcagatt tttaaagtta ctttataacc attttgtcca tttgatgcca   2880

ttgtttatca tcttttgaga aaaaagttct gtcataccct tctctccaca aaaaagagac   2940

tgagggggag atcaagtgaa agggtgcaag caaacttagt gactccttga ggtgtttgtc   3000

agttttggct tttttctcct ttgttgtatt ctttatgtat tgtcttaatg tacttaatat   3060

tacctgagtt tgaaatggat gaagacagct gctaccatta agggccaaat tttatgctac   3120

cactaaacaa aaatacccac tcagtctgtg ttaaattgta tgtcttttta aaggtattta   3180

gagattcaac taagctttaa agagggctga gcaactcagg aagcctgtaa tgtgggcata   3240

actctttgga cctgatcttg atgcttctgc tgctctgttg gcctctgaag agcaatatct   3300

aatttattat tactgtaatt ttttaaaagg ctttaaagtg cctcaggggt cccctgaaac   3360

taattttcta tttctgggat tccctggatt cattatatga gatggtgaca tgattagagg   3420

aattcttttt tagtatgaaa attgttcctt ttcttcttca gtacttgcct ccttgctggc   3480

attgaattaa cacagggaca aaatttggtt aattttttat ttctaattct cccaacaaac   3540

ccctgttgcc cagtatttat gtggtggcct ttaaccacct gagggaaaaa atgagcttat   3600

tcaagctgcc aatatttatc tatgggctgt agcagtacac tgaattgtac tgtgccaggg   3660

atattgagat gctctggggg tgtattgtat acctgccagt tttcttcatt tctgaattgg   3720

gttttctctt cttgatgttg gtttccttca tatcacctca aggtttagat ttgtgaagga   3780

ataagcatga tggaaataat agtcttgaaa ggagatatgt tgtatataat caggaggaag   3840

aggaaggcag gacttactca ttttgatatt ttgctgtagg tggccagttt tgtttctcat   3900

agggaaatct gacccacctg tcatgttggc tcctaaggaa ctgctgttgt aagcggctca   3960

tcaagagttg aacttcaagt agccttgttg ggaatatgga aaaggaagaa agccacagga   4020

ctgcccattc agtcttgtta agattgggat gattctgcac aagcaaaaat gactcgaaat   4080

ttatgtatcg acacacctct accaatccat cttcagctga ctgaatgttg tatgatagcc   4140

cttctccaaa gcaggggtag aatgttcagg tttcaccacg gattttctac ttatttcgct   4200

tttggaatca gcttacagat tccaggtccc ttttgtatat attctttatt cttttgcttt   4260

tttaaaaaat aaacttgtat tagtcaatgt ttcgtgttcc gcattatttg aaccatttgc   4320

ccttacagaa agagaaatac ttgtttgtgt tttaaataaa actgatgt                4368


<210>  4354
<211>  805
<212>  PRT
<213>  Homosapiens

<400>  4354

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Val Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Thr Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320 


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350         


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495     


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510         


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525             


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540                 


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560 


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575     


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590         


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605             


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620                 


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640 


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655     


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670         


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685             


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700                 


Val Val Leu Leu Asp Ser Glu Asp Lys Ser Val Thr Val Pro Glu Ala 
705                 710                 715                 720 


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Pro Thr Gln Ser Ser Ser 
                725                 730                 735     


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750         


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765             


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780                 


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800 


Leu Pro Leu Glu Leu 
                805 


<210>  4355
<211>  4667
<212>  DNA
<213>  Homosapiens

<400>  4355
cggacggcag cggccaagca agaagaaaga cgtggcagca agcgggagtc ggggatagtg     60

tcatcggttc gggtcccact actttggagc ttgtctcaaa ctccacatac agaaagccac    120

caaccttatt ccggtatcct acacccattc cccaccctca ttacactccc acccctggcc    180

ctcagcatgg gagtcaagag caacagggac acttccgtac tccttgtagg attggtgaaa    240

ccgtaatgaa gaacacccct aaactcccat aattggattt ggggatattc cctgcccaaa    300

aaattcctgg aaaattgact agtattaagt gcataataga ttggaactca gtgaagacac    360

agacgttcct gttgagagca accagctaat gattacagtt taaagacaat ttctgtgatc    420

aagttgtcat ttggaagatt aaacccattt cacgaggact tggagcctgg tccttgcttt    480

gaggaagcag tggcttgttt caagaagcca cttctgatct aagaatctac ccagcatgcc    540

taatcaagga gaagactgct attttttttt ctattctaca tgtaccaaag gtgacagctg    600

cccattccgt cactgtgaag ctgcactagg caatgaaact gtttgcacat tatggcaaga    660

agggcgctgt tttcgacggg tgtgcaggtt tcggcacatg gagattgata aaaaacgcag    720

tgaaattcct tgttattggg aaaatcagcc aacaggatgt caaaaattaa actgcgtttt    780

ccatcacaat agaggacgat atgttgatgg ccttttccta cctccgagca aaagtgtgtt    840

gcccactgtg cctgagtcac cagaagagga agtgaaggct agccaacttt cagttcagca    900

gaacaaattg tctgtccagt ccaatacttc ccctcagctg cggagcgtta tgaaagtaga    960

aagttccgaa aatgttccta gccccaagca tccaccagtt gtaattaatg ctgcagatga   1020

tgatgaagat gatgatgatc agttttctga ggaaggtgat gaaaccaaaa cacctaccct   1080

gcaaccaact cctgaagttc acaatggatt acgagtgact tctgtccgga aacctgcagt   1140

caatataaag caaggtgaat gtttgcattt tggaataaaa actcttgagg aaattaagtc   1200

aaagaaaatg aaggaaaaat ctgaggagca aggtgagggt tcttcaggag tttccagtct   1260

tttactccac cctgagcctg ttccaggtcc tgaaaaagaa aatgtcagga ctgtggtgag   1320

gacagtaact ctctccacca aacaaggaga agaacccttg gttagattgg gccttactga   1380

gacactgggg aaacgaaaat tttcgacagg cggtgacagt gatcctccat taaagcgtag   1440

cctggcacag aggctaggga agaaagttga agctccagaa actaacactg acgaaacacc   1500

aaagaaagct caagtttcca agtctcttaa ggagcgatta ggcatgtcag ctgatccaaa   1560

taatgaggac gcaacagata aagttaataa agttggtgag atccatgtga agacattaga   1620

agaaatgctt cttgaaagag ccagtcagaa acatggggaa tcgcaaacta aactcaagac   1680

agaaggacct tcaaaaactg atgattctac ttcaggagca agaagctcct ccactatccg   1740

tatcaaaacc ttctctgagg tcctggctga agaagaacat aggcagcagg aagcagagag   1800

acaaaaaagc aaaaaggata caacttgcat caagctaaag actgatagtg aaattaaaaa   1860

aacagtagtt ttgccaccca ttgttgccag caaaggacaa tcagaggagc ctgcaggtaa   1920

aacaaagtcc atgcaggagg tgcacatgaa gacggtggaa gaaattaaac tggagaaggc   1980

actgagggtg cagcagagct ctgagagcag caccagctcc ccgtctcaac atgaggccac   2040

tccaggggca aggttgctgc tgcgaatcac caaaagaaca tggaggaaag aagagaagaa   2100

acttcaggaa ggaaatgaag ttgattttct gagccgtgtt agaatggaag ctacagaggc   2160

ttcagttgag accacaggag ttgacatcac taaaattcaa gtcaagagat gtgagatcat   2220

gagagagacg cgcatgcaga aacagcagga gagggaaaaa tcagtcttga cacctcttca   2280

gggagatgta gcctcttgca atacccaagt ggcagagaaa ccagtgctca ctgctgtgcc   2340

aggaatcaca tggcacctga ccaagcagct tcccacaaag tcatcccaga aggtggaggt   2400

agaaacctca gggattgcag actcattatt gaatgtgaaa tggtcagcac agaccttgga   2460

aaaaaggggt gaagctaaac ccacagtgaa cgtgaagcaa tctgtggtta aagttgtgtc   2520

atcccccaaa ttggccccaa aacgtaaggc agtggagatg caccctgctg tcactgccgc   2580

tgtgaagcca ctcagctcca gcagcgtcct acaggaaccc ccagccaaaa aggcagctgt   2640

ggatgctgtt gtcctgcttg actctgagga caaatcagtc actgtgcctg aagcagaaaa   2700

tcctagagac agtcttgtgc tgcctccaac ccagtcctct tcagattcct cacccccgga   2760

ggtgtctggc ccttcctcat cccaaatgag catgaaaact cgccgactca gctctgcctc   2820

aacaggaaag cccccactct ctgtggagga tgattttgag aaactaacat gggagatttc   2880

aggaggcaaa ttggaagctg agattgacct ggatcctggg aaagatgaag atgaccttcc   2940

gcttgagcta tgagaaatga ttgatagctg aaggtggtag tgaggacact ttaaaaaaaa   3000

atcgccaaaa aactggactt agtttcatct attgtaacat ttacctgaga tgatcatttc   3060

tttagtctag aatttgcccc aaatcagaag tatacctctg aattatctgt atgtgtcctg   3120

gattccttgg ggtcagattt ttaaagttac tttataacca ttttgtccat ttgatgccat   3180

tgtttatcat cttttgagaa aaaagttctg tcataccctt ctctccacaa aaaagagact   3240

gagggggaga tcaagtgaaa gggtgcaagc aaacttagtg actccttgag gtgtttgtca   3300

gttttggctt ttttctcctt tgttgtattc tttatgtatt gtcttaatgt acttaatatt   3360

acctgagttt gaaatggatg aagacagctg ctaccattaa gggccaaatt ttatgctacc   3420

actaaacaaa aatacccact cagtctgtgt taaattgtat gtctttttaa aggtatttag   3480

agattcaact aagctttaaa gagggctgag caactcagga agcctgtaat gtgggcataa   3540

ctctttggac ctgatcttga tgcttctgct gctctgttgg cctctgaaga gcaatatcta   3600

atttattatt actgtaattt tttaaaaggc tttaaagtgc ctcaggggtc ccctgaaact   3660

aattttctat ttctgggatt ccctggattc attatatgag atggtgacat gattagagga   3720

attctttttt agtatgaaaa ttgttccttt tcttcttcag tacttgcctc cttgctggca   3780

ttgaattaac acagggacaa aatttggtta attttttatt tctaattctc ccaacaaacc   3840

cctgttgccc agtatttatg tggtggcctt taaccacctg agggaaaaaa tgagcttatt   3900

caagctgcca atatttatct atgggctgta gcagtacact gaattgtact gtgccaggga   3960

tattgagatg ctctgggggt gtattgtata cctgccagtt ttcttcattt ctgaattggg   4020

ttttctcttc ttgatgttgg tttccttcat atcacctcaa ggtttagatt tgtgaaggaa   4080

taagcatgat ggaaataata gtcttgaaag gagatatgtt gtatataatc aggaggaaga   4140

ggaaggcagg acttactcat tttgatattt tgctgtaggt ggccagtttt gtttctcata   4200

gggaaatctg acccacctgt catgttggct cctaaggaac tgctgttgta agcggctcat   4260

caagagttga acttcaagta gccttgttgg gaatatggaa aaggaagaaa gccacaggac   4320

tgcccattca gtcttgttaa gattgggatg attctgcaca agcaaaaatg actcgaaatt   4380

tatgtatcga cacacctcta ccaatccatc ttcagctgac tgaatgttgt atgatagccc   4440

ttctccaaag caggggtaga atgttcaggt ttcaccacgg attttctact tatttcgctt   4500

ttggaatcag cttacagatt ccaggtccct tttgtatata ttctttattc ttttgctttt   4560

ttaaaaaata aacttgtatt agtcaatgtt tcgtgttccg cattatttga accatttgcc   4620

cttacagaaa gagaaatact tgtttgtgtt ttaaataaaa ctgatgt                 4667


<210>  4356
<211>  805
<212>  PRT
<213>  Homosapiens

<400>  4356

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Val Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Thr Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320 


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350         


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495     


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510         


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525             


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540                 


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560 


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575     


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590         


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605             


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620                 


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640 


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655     


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670         


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685             


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700                 


Val Val Leu Leu Asp Ser Glu Asp Lys Ser Val Thr Val Pro Glu Ala 
705                 710                 715                 720 


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Pro Thr Gln Ser Ser Ser 
                725                 730                 735     


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750         


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765             


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780                 


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800 


Leu Pro Leu Glu Leu 
                805 


<210>  4357
<211>  4949
<212>  DNA
<213>  Homosapiens

<400>  4357
cagcggccaa gcaagaagaa agacgtggca gcaagcggga gtcggggata gtgtcatcgg     60

ttcgggtccc actactttgg agcttgtctc aaactccaca tacagaaagc caccaacctt    120

attccggtat cctacaccca ttccccaccc tcattacact cccacccctg gccctcagca    180

tgggagtcaa gagcaacagg gacacttccg tactccttgt aggattggtg aaaccgtaat    240

gaagaacacc cctaaactcc cataattgga tttggggata ttccctgccc aaaaaattcc    300

tggaaaattg actagtatta agtctatgga agatggattt tttttcatga tcctttgact    360

ctcaagttca tctttaaatg aactcttttt tttgttttgt ttttgaggag ataactaacc    420

cttgctgtct ccagtctgac aaaggttatt tgaatggact taatctccca gtagttggga    480

gatgttttaa aaacacatgc tgtgtttgaa ttgtggctga gaggttttct tggcaatgtg    540

aggaggaaaa ttttttctgc ctcattatta ttaattcatg gattgagtgt tggttcgacc    600

tacaggcata atagattgga actcagtgaa gacacagacg ttcctgttga gagcaaccag    660

ctaatgatta cagtttaaag acaatttctg tgatcaagtt gtcatttgga agattaaacc    720

catttcacga ggacttggag cctggtcctt gctttgagga agcagtggct tgtttcaaga    780

agccacttct gatctaagaa tctacccagc atgcctaatc aaggagaaga ctgctatttt    840

tttttctatt ctacatgtac caaaggtgac agctgcccat tccgtcactg tgaagctgca    900

ctaggcaatg aaactgtttg cacattatgg caagaagggc gctgttttcg acgggtgtgc    960

aggtttcggc acatggagat tgataaaaaa cgcagtgaaa ttccttgtta ttgggaaaat   1020

cagccaacag gatgtcaaaa attaaactgc gttttccatc acaatagagg acgatatgtt   1080

gatggccttt tcctacctcc gagcaaaagt gtgttgccca ctgtgcctga gtcaccagaa   1140

gaggaagtga aggctagcca actttcagtt cagcagaaca aattgtctgt ccagtccaat   1200

acttcccctc agctgcggag cgttatgaaa gtagaaagtt ccgaaaatgt tcctagcccc   1260

aagcatccac cagttgtaat taatgctgca gatgatgatg aagatgatga tgatcagttt   1320

tctgaggaag gtgatgaaac caaaacacct accctgcaac caactcctga agttcacaat   1380

ggattacgag tgacttctgt ccggaaacct gcagtcaata taaagcaagg tgaatgtttg   1440

cattttggaa taaaaactct tgaggaaatt aagtcaaaga aaatgaagga aaaatctgag   1500

gagcaaggtg agggttcttc aggagtttcc agtcttttac tccaccctga gcctgttcca   1560

ggtcctgaaa aagaaaatgt caggactgtg gtgaggacag taactctctc caccaaacaa   1620

ggagaagaac ccttggttag attgggcctt actgagacac tggggaaacg aaaattttcg   1680

acaggcggtg acagtgatcc tccattaaag cgtagcctgg cacagaggct agggaagaaa   1740

gttgaagctc cagaaactaa cactgacgaa acaccaaaga aagctcaagt ttccaagtct   1800

cttaaggagc gattaggcat gtcagctgat ccaaataatg aggacgcaac agataaagtt   1860

aataaagttg gtgagatcca tgtgaagaca ttagaagaaa tgcttcttga aagagccagt   1920

cagaaacatg gggaatcgca aactaaactc aagacagaag gaccttcaaa aactgatgat   1980

tctacttcag gagcaagaag ctcctccact atccgtatca aaaccttctc tgaggtcctg   2040

gctgaagaag aacataggca gcaggaagca gagagacaaa aaagcaaaaa ggatacaact   2100

tgcatcaagc taaagactga tagtgaaatt aaaaaaacag tagttttgcc acccattgtt   2160

gccagcaaag gacaatcaga ggagcctgca ggtaaaacaa agtccatgca ggaggtgcac   2220

atgaagacgg tggaagaaat taaactggag aaggcactga gggtgcagca gagctctgag   2280

agcagcacca gctccccgtc tcaacatgag gccactccag gggcaaggtt gctgctgcga   2340

atcaccaaaa gaacatggag gaaagaagag aagaaacttc aggaaggaaa tgaagttgat   2400

tttctgagcc gtgttagaat ggaagctaca gaggcttcag ttgagaccac aggagttgac   2460

atcactaaaa ttcaagtcaa gagatgtgag atcatgagag agacgcgcat gcagaaacag   2520

caggagaggg aaaaatcagt cttgacacct cttcagggag atgtagcctc ttgcaatacc   2580

caagtggcag agaaaccagt gctcactgct gtgccaggaa tcacatggca cctgaccaag   2640

cagcttccca caaagtcatc ccagaaggtg gaggtagaaa cctcagggat tgcagactca   2700

ttattgaatg tgaaatggtc agcacagacc ttggaaaaaa ggggtgaagc taaacccaca   2760

gtgaacgtga agcaatctgt ggttaaagtt gtgtcatccc ccaaattggc cccaaaacgt   2820

aaggcagtgg agatgcaccc tgctgtcact gccgctgtga agccactcag ctccagcagc   2880

gtcctacagg aacccccagc caaaaaggca gctgtggatg ctgttgtcct gcttgactct   2940

gaggacaaat cagtcactgt gcctgaagca gaaaatccta gagacagtct tgtgctgcct   3000

ccaacccagt cctcttcaga ttcctcaccc ccggaggtgt ctggcccttc ctcatcccaa   3060

atgagcatga aaactcgccg actcagctct gcctcaacag gaaagccccc actctctgtg   3120

gaggatgatt ttgagaaact aacatgggag atttcaggag gcaaattgga agctgagatt   3180

gacctggatc ctgggaaaga tgaagatgac cttccgcttg agctatgaga aatgattgat   3240

agctgaaggt ggtagtgagg acactttaaa aaaaaatcgc caaaaaactg gacttagttt   3300

catctattgt aacatttacc tgagatgatc atttctttag tctagaattt gccccaaatc   3360

agaagtatac ctctgaatta tctgtatgtg tcctggattc cttggggtca gatttttaaa   3420

gttactttat aaccattttg tccatttgat gccattgttt atcatctttt gagaaaaaag   3480

ttctgtcata cccttctctc cacaaaaaag agactgaggg ggagatcaag tgaaagggtg   3540

caagcaaact tagtgactcc ttgaggtgtt tgtcagtttt ggcttttttc tcctttgttg   3600

tattctttat gtattgtctt aatgtactta atattacctg agtttgaaat ggatgaagac   3660

agctgctacc attaagggcc aaattttatg ctaccactaa acaaaaatac ccactcagtc   3720

tgtgttaaat tgtatgtctt tttaaaggta tttagagatt caactaagct ttaaagaggg   3780

ctgagcaact caggaagcct gtaatgtggg cataactctt tggacctgat cttgatgctt   3840

ctgctgctct gttggcctct gaagagcaat atctaattta ttattactgt aattttttaa   3900

aaggctttaa agtgcctcag gggtcccctg aaactaattt tctatttctg ggattccctg   3960

gattcattat atgagatggt gacatgatta gaggaattct tttttagtat gaaaattgtt   4020

ccttttcttc ttcagtactt gcctccttgc tggcattgaa ttaacacagg gacaaaattt   4080

ggttaatttt ttatttctaa ttctcccaac aaacccctgt tgcccagtat ttatgtggtg   4140

gcctttaacc acctgaggga aaaaatgagc ttattcaagc tgccaatatt tatctatggg   4200

ctgtagcagt acactgaatt gtactgtgcc agggatattg agatgctctg ggggtgtatt   4260

gtatacctgc cagttttctt catttctgaa ttgggttttc tcttcttgat gttggtttcc   4320

ttcatatcac ctcaaggttt agatttgtga aggaataagc atgatggaaa taatagtctt   4380

gaaaggagat atgttgtata taatcaggag gaagaggaag gcaggactta ctcattttga   4440

tattttgctg taggtggcca gttttgtttc tcatagggaa atctgaccca cctgtcatgt   4500

tggctcctaa ggaactgctg ttgtaagcgg ctcatcaaga gttgaacttc aagtagcctt   4560

gttgggaata tggaaaagga agaaagccac aggactgccc attcagtctt gttaagattg   4620

ggatgattct gcacaagcaa aaatgactcg aaatttatgt atcgacacac ctctaccaat   4680

ccatcttcag ctgactgaat gttgtatgat agcccttctc caaagcaggg gtagaatgtt   4740

caggtttcac cacggatttt ctacttattt cgcttttgga atcagcttac agattccagg   4800

tcccttttgt atatattctt tattcttttg cttttttaaa aaataaactt gtattagtca   4860

atgtttcgtg ttccgcatta tttgaaccat ttgcccttac agaaagagaa atacttgttt   4920

gtgttttaaa taaaactgat gtaggataa                                     4949


<210>  4358
<211>  805
<212>  PRT
<213>  Homosapiens

<400>  4358

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Val Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Thr Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320 


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350         


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495     


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510         


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525             


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540                 


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560 


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575     


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590         


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605             


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620                 


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640 


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655     


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670         


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685             


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700                 


Val Val Leu Leu Asp Ser Glu Asp Lys Ser Val Thr Val Pro Glu Ala 
705                 710                 715                 720 


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Pro Thr Gln Ser Ser Ser 
                725                 730                 735     


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750         


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765             


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780                 


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800 


Leu Pro Leu Glu Leu 
                805 


<210>  4359
<211>  4163
<212>  DNA
<213>  Homosapiens

<400>  4359
gcacttttac cggccgggcc ttagagcgca gcctgtagcc gggcgccatc tttgacgctg     60

gcagtcttgg ttttctgcta gtgctgctgc tgctgggagg acgacggacg gcagcggcca    120

agcaagaaga aagacgtggc agcaagcggg agtcggggat agtgtcatcg gttcggtgat    180

gctttttagg atttggggat attccctgcc caaaaaattc ctggaaaatt gactagtatt    240

aagtgcgtaa tagattggaa ctcagtgaag acacagacgt tcctgttgag agcaatcagc    300

taatgattac agtttaaaga caatttctgt gatcaagttg tcatttggaa gattaaaccc    360

atttcacgag gacttggagc ctggtccttg ctttgaggaa gcagtggctt gtttcaagaa    420

gccacttctg atctaagaat ctacccagca tgcctaatca aggagaagac tgctattttt    480

ttttctattc tacatgtacc aaaggtgaca gctgcccatt ccgtcactgt gaagctgcac    540

taggcaatga aactgtttgc acattatggc aagaagggcg ctgttttcga cgggtgtgca    600

ggtttcggca catggagatt gataaaaaac gcagtgaaat tccttgttat tgggaaaatc    660

agccaacagg atgtcaaaaa ttaaactgcg ctttccatca caatagagga cgatatgttg    720

atggcctttt cctacctccg agcaaaagtg tgttgcccac tgtgcctgag tcaccagaag    780

aggaagtgaa ggctagccaa ctttcagttc agcagaacaa attgtctgtc cagtccaata    840

cttcccctca gctgcggagc gttatgaaag tagaaagttc cgaaaatgtt cctagcccca    900

agcatccacc agttgtaatt aatgctgcag atgatgatga agatgatgat gatcagtttt    960

ctgaggaagg tgatgaaacc aaaacaccta ccctgcaacc aactcctgaa gttcacaatg   1020

gattacgagt gacttctgtc cggaaacctg cagtcaatat aaagcaaggt gaatgtttgc   1080

attttggaat aaaaactctt gaggaaatta agtcaaagaa aatgaaggaa aaatctgagg   1140

agcaaggtga gggttcttca ggagtttcca gtcttttact ccaccctgag cctgttccag   1200

gtcctgaaaa agaaaatgtc aggactgtgg tgaggacagt aactctctcc accaaacaag   1260

gagaagaacc cttggttaga ttgggcctta ctgagacact ggggaaacga aaattttcga   1320

caggcggtga cagtgatcct ccattaaagc gcagcctggc acagaggcta gggaagaaag   1380

ttgaagctcc agaaactaac actgacgaaa caccaaagaa agctcaagtt tccaagtctc   1440

ttaaggagcg attaggcatg tcagctgatc caaataatga ggacgcaaca gataaagtta   1500

ataaagttgg tgagatccat gtgaagacat tagaagaaat gcttcttgaa agagccagtc   1560

agaaacatgg ggaatcgcaa actaaactca agacagaagg accttcaaaa actgatgatt   1620

ctacttcagg agcaagaagc tcctccacta tccgtatcaa aaccttctct gaggtcctgg   1680

ctgaagaaga acataggcag caggaagcag agagacaaaa aagcaaaaag gatacaactt   1740

gcatcaagct aaagactgat agtgaaatta aaaaaacagt agttttgcca cccattgttg   1800

ccagcaaagg acaatcagag gagcctgcag gtaaaacaaa gtccatgcag gaggtgcaca   1860

tgaagacggt ggaagaaatt aaactggaga aggcactgag ggtgcagcag agctctgaga   1920

gcagcaccag ctccccgtct caacatgagg ccactccagg ggcaaggttg ctactgcgaa   1980

tcaccaaaag aacatggagg aaagaagaga agaaacttca ggaaggaaat gaagttgatt   2040

ttctgagccg tgttagaatg gaagctacag aggcttcagt tgagaccaca ggagttgaca   2100

tcactaaaat tcaagtcaag agatgtgaga tcatgagaga gacgcgcatg cagaaacagc   2160

aggagaggga aaaatcagtc ttgacacctc ttcagggaga tgtagcctct tgcaataccc   2220

aagtggcaga gaaaccagtg ctcactgctg tgccaggaat cacatggcac ctgaccaagc   2280

agcttcccac aaagtcatcc cagaaggtgg aggtagaaac ctcagggatt gcagactcat   2340

tattgaatgt gaaatggtca gcacagacct tggaaaaaag gggtgaagct aaacccacag   2400

tgaacgtgaa gcaatctgtg gttaaagttg tgtcatcccc caaattggcc ccaaaacgta   2460

aggcagtgga gatgcaccct gctgtcactg ccgctgtgaa gccactcagc tccagcagcg   2520

tcctacagga acccccagcc aaaaaggcag ctgtggatgc tgttgtcctg cttgtctctg   2580

aggacaaatc agtcactgtg cctgaagcag aaaatcctag agacagtctt gtgctgcctc   2640

caacccagtc ctcttcagat tcctcacccc cggaggtgtc tggcccttcc tcatcccaaa   2700

tgagcatgaa aactcgccga ctcagctctg cctcaacagg aaagccccca ctctctgtgg   2760

aggatgattt tgagaaacta acatgggaga tttcaggagg caaattggaa gctgagattg   2820

acctggatcc tgggaaagat gaagatgacc ttccgcttga gctatgagaa atgattgata   2880

gctgaaggtg gtagtgagga cactttaaaa aaaaaatcgc caaaaaactg gacttagttt   2940

catctattgt aacatttacc tgagatgatc atttctttag tctagaattt gccccaaatc   3000

agaagtatac ctctgaatta tctgtatgtg tcctggattc cttggggtca gatttttaaa   3060

gttactttat aaccattttg tccatttgat gccattgttt atcatctttt gagaaaaaag   3120

ttctgtcata cccttctctc cacaaaaaag agactgagag ggagatcaag tgaaagggtg   3180

caagcaaact tagtgactcc ttgaggtgtt tgtcagtttt ggcttttttc tcctttgttg   3240

tattctttat gtattgtctt gatgtactta atattacctg agtttgaaat ggatgaagac   3300

agctgctacc attaaggacc aaattttatg ctaccactaa acaaaaatac ccactcagtc   3360

tgtgttaaat tgtatgtctt tttaaaggta tttagagatt caactaagct ttaaagaggg   3420

ctgagcagct caggaagcct gtaatgtggg cataactctt tggacctgat cttgatgctt   3480

ctgctgctct gttggcctct gaagagcaat atctaattta ttattactgt aattttttaa   3540

aaggctttaa agtgcctcag gggtcccctg aaactaattt tctatttctg ggattccctg   3600

gattcattat atgagatggt gacatgatta gaggaattct tttttagtat gaaaattgtc   3660

ccttttcttc ttcagtactt gcctccttgc tggcattgaa ttaacacagg gacaaaattt   3720

ggttaatttt ttatttctaa ttctcccaac aaacccctgt tgcccagtat ttatgtggtg   3780

gcctttaacc acctgaggga aaaaatgagc ttattcaagc tgccaatatt tatctatggg   3840

ctgtagcagt acactgaatt gtactgtgcc agggatattg agatgctctg ggggtgtatt   3900

gtatacctgc cagttttctt catttctgaa ttgagttttc ttttcttgat gttggtttcc   3960

ttcatatcac ctcaaggttt agatttgtga aggaataagc atgatggaaa taatagtctt   4020

gaaaggagat atgttgtata taatcaggag gaagaggaag gaaggactta cccattttga   4080

tattttgctg taggtggcca gttttgtttc tcatagggaa atctgaccca cctgtcatgt   4140

tggctcctaa ggaactgctg ttg                                           4163


<210>  4360
<211>  805
<212>  PRT
<213>  Homosapiens

<400>  4360

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Thr Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320 


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350         


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495     


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510         


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525             


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540                 


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560 


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575     


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590         


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605             


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620                 


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640 


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655     


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670         


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685             


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700                 


Val Val Leu Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Ala 
705                 710                 715                 720 


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Pro Thr Gln Ser Ser Ser 
                725                 730                 735     


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750         


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765             


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780                 


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800 


Leu Pro Leu Glu Leu 
                805 


<210>  4361
<211>  4668
<212>  DNA
<213>  Homosapiens

<400>  4361
gctagtgctg ctgctgctgg gaggacgacg gacggcagcg gccaagcaag aagaaagacg     60

tggcagcaag cgggagtcgg ggatagtgtc atcggttcgg gtcccactac tttggagctt    120

gtctcaaact ccacatacag aaagccaccg accttattcc ggtatcctac acccattccc    180

caccctcatt acactcccac ccctggccct cagcgtggga gtcaagagca acagggacac    240

ttccgtactc cttgtaggat tggtgaaacc gtaatgacga acacccctaa actcccataa    300

ttggtgcgga ttcctgtggg gaaggcctat actgttgaca tcttccaggc catctcaagg    360

ttctggacct tgagaaggag gctgtggaac tagagatagt gatgcttttt aggatttggg    420

gatattccct gcccaaaaaa ttcctggaaa attgactagt attaagtcta tggaagatgg    480

attttttttc atgatccttt gactctcaag ttcatcttta aatgaactct tttttttgtt    540

ttgtttttga ggagataact aaccctagct gtctccagtc tgacaaaggt tatttgaatg    600

gacttaatct cccagtagtt gggagatgtt ttaaaaacac atgctgtgtt tgaattgtgg    660

ctgagaggtt ttcttggcaa tgtgaggagg aaaatttttt ctgcttcatt attattaatt    720

catggattga gtgttggttc gacctacagg cgtaatagat tggaactcag tgaagacaca    780

gacgttcctg ttgagagcaa tcagctaatg attacagttt aaagacaatt tctgtgatca    840

agttgtcatt tggaagatta aacccatttc acgaggactt ggagcctggt ccttgctttg    900

aggaagcagt ggcttgtttc aagaagccac ttctgatcta agaatctacc cagcatgcct    960

aatcaaggag aagactgcta tttttttttc tattctacat gtaccaaagg tgacagctgc   1020

ccattccgtc actgtgaagc tgcactaggc aatgaaactg tttgcacatt atggcaagaa   1080

gggcgctgtt ttcgacgggt gtgcaggttt cggcacatgg agattgataa aaaacgcagt   1140

gaaattcctt gttattggga aaatcagcca acaggatgtc aaaaattaaa ctgcgctttc   1200

catcacaata gaggacgata tgttgatggc cttttcctac ctccgagcaa aagtgtgttg   1260

cccactgtgc ctgagtcacc agaagaggaa gtgaaggcta gccaactttc agttcagcag   1320

aacaaattgt ctgtccagtc caatacttcc cctcagctgc ggagcgttat gaaagtagaa   1380

agttccgaaa atgttcctag ccccaagcat ccaccagttg taattaatgc tgcagatgat   1440

gatgaagatg atgatgatca gttttctgag gaaggtgatg aaaccaaaac acctaccctg   1500

caaccaactc ctgaagttca caatggatta cgagtgactt ctgtccggaa acctgcagtc   1560

aatataaagc aaggtgaatg tttgcatttt ggaataaaaa ctcttgagga aattaagtca   1620

aagaaaatga aggaaaaatc tgaggagcaa ggtgagggtt cttcaggagt ttccagtctt   1680

ttactccacc ctgagcctgt tccaggtcct gaaaaagaaa atgtcaggac tgtggtgagg   1740

acagtaactc tctccaccaa acaaggagaa gaacccttgg ttagattggg ccttactgag   1800

acactgggga aacgaaaatt ttcgacaggc ggtgacagtg atcctccatt aaagcgcagc   1860

ctggcacaga ggctagggaa gaaagttgaa gctccagaaa ctaacactga cgaaacacca   1920

aagaaagctc aagtttccaa gtctcttaag gagcgattag gcatgtcagc tgatccaaat   1980

aatgaggacg caacagataa agttaataaa gttggtgaga tccatgtgaa gacattagaa   2040

gaaatgcttc ttgaaagagc cagtcagaaa catggggaat cgcaaactaa actcaagaca   2100

gaaggacctt caaaaactga tgattctact tcaggagcaa gaagctcctc cactatccgt   2160

atcaaaacct tctctgaggt cctggctgaa gaagaacata ggcagcagga agcagagaga   2220

caaaaaagca aaaaggatac aacttgcatc aagctaaaga ctgatagtga aattaaaaaa   2280

acagtagttt tgccacccat tgttgccagc aaaggacaat cagaggagcc tgcaggtaaa   2340

acaaagtcca tgcaggaggt gcacatgaag acggtggaag aaattaaact ggagaaggca   2400

ctgagggtgc agcagagctc tgagagcagc accagctccc cgtctcaaca tgaggccact   2460

ccaggggcaa ggttgctact gcgaatcacc aaaagaacat ggaggaaaga agagaagaaa   2520

cttcaggaag gaaatgaagt tgattttctg agccgtgtta gaatggaagc tacagaggct   2580

tcagttgaga ccacaggagt tgacatcact aaaattcaag tcaagagatg tgagatcatg   2640

agagagacgc gcatgcagaa acagcaggag agggaaaaat cagtcttgac acctcttcag   2700

ggagatgtag cctcttgcaa tacccaagtg gcagagaaac cagtgctcac tgctgtgcca   2760

ggaatcacat ggcacctgac caagcagctt cccacaaagt catcccagaa ggtggaggta   2820

gaaacctcag ggattgcaga ctcattattg aatgtgaaat ggtcagcaca gaccttggaa   2880

aaaaggggtg aagctaaacc cacagtgaac gtgaagcaat ctgtggttaa agttgtgtca   2940

tcccccaaat tggccccaaa acgtaaggca gtggagatgc accctgctgt cactgccgct   3000

gtgaagccac tcagctccag cagcgtccta caggaacccc cagccaaaaa ggcagctgtg   3060

gatgctgttg tcctgcttgt ctctgaggac aaatcagtca ctgtgcctga agcagaaaat   3120

cctagagaca gtcttgtgct gcctccaacc cagtcctctt cagattcctc acccccggag   3180

gtgtctggcc cttcctcatc ccaaatgagc atgaaaactc gccgactcag ctctgcctca   3240

acaggaaagc ccccactctc tgtggaggat gattttgaga aactaacatg ggagatttca   3300

ggaggcaaat tggaagctga gattgacctg gatcctggga aagatgaaga tgaccttccg   3360

cttgagctat gagaaatgat tgatagctga aggtggtagt gaggacactt taaaaaaaaa   3420

atcgccaaaa aactggactt agtttcatct attgtaacat ttacctgaga tgatcatttc   3480

tttagtctag aatttgcccc aaatcagaag tatacctctg aattatctgt atgtgtcctg   3540

gattccttgg ggtcagattt ttaaagttac tttataacca ttttgtccat ttgatgccat   3600

tgtttatcat cttttgagaa aaaagttctg tcataccctt ctctccacaa aaaagagact   3660

gagagggaga tcaagtgaaa gggtgcaagc aaacttagtg actccttgag gtgtttgtca   3720

gttttggctt ttttctcctt tgttgtattc tttatgtatt gtcttgatgt acttaatatt   3780

acctgagttt gaaatggatg aagacagctg ctaccattaa ggaccaaatt ttatgctacc   3840

actaaacaaa aatacccact cagtctgtgt taaattgtat gtctttttaa aggtatttag   3900

agattcaact aagctttaaa gagggctgag cagctcagga agcctgtaat gtgggcataa   3960

ctctttggac ctgatcttga tgcttctgct gctctgttgg cctctgaaga gcaatatcta   4020

atttattatt actgtaattt tttaaaaggc tttaaagtgc ctcaggggtc ccctgaaact   4080

aattttctat ttctgggatt ccctggattc attatatgag atggtgacat gattagagga   4140

attctttttt agtatgaaaa ttgtcccttt tcttcttcag tacttgcctc cttgctggca   4200

ttgaattaac acagggacaa aatttggtta attttttatt tctaattctc ccaacaaacc   4260

cctgttgccc agtatttatg tggtggcctt taaccacctg agggaaaaaa tgagcttatt   4320

caagctgcca atatttatct atgggctgta gcagtacact gaattgtact gtgccaggga   4380

tattgagatg ctctgggggt gtattgtata cctgccagtt ttcttcattt ctgaattgag   4440

ttttcttttc ttgatgttgg tttccttcat atcacctcaa ggtttagatt tgtgaaggaa   4500

taagcatgat ggaaataata gtcttgaaag gagatatgtt gtatataatc aggaggaaga   4560

ggaaggaagg acttacccat tttgatattt tgctgtaggt ggccagtttt gtttctcata   4620

gggaaatctg acccacctgt catgttggct cctaaggaac tgctgttg                4668


<210>  4362
<211>  805
<212>  PRT
<213>  Homosapiens

<400>  4362

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Thr Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320 


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350         


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495     


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510         


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525             


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540                 


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560 


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575     


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590         


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605             


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620                 


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640 


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655     


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670         


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685             


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700                 


Val Val Leu Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Ala 
705                 710                 715                 720 


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Pro Thr Gln Ser Ser Ser 
                725                 730                 735     


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750         


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765             


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780                 


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800 


Leu Pro Leu Glu Leu 
                805 


<210>  4363
<211>  3950
<212>  DNA
<213>  Homosapiens

<400>  4363
gcaacctcca cctcccagat tcaagcaatt ctcctgcctc agcctcctga gtagctggga     60

ttacaggcgc gtactaccat gcctggctaa tgattacagt ttaaagacaa tttctgtgat    120

caagttgtca tttggaagat taaacccatt tcacgaggac ttggagcctg gtccttgctt    180

tgaggaagca gtggcttgtt tcaagaagcc acttctgatc taagaatcta cccagcatgc    240

ctaatcaagg agaagactgc tatttttttt tctattctac atgtaccaaa ggtgacagct    300

gcccattccg tcactgtgaa gctgcactag gcaatgaaac tgtttgcaca ttatggcaag    360

aagggcgctg ttttcgacgg gtgtgcaggt ttcggcacat ggagattgat aaaaaacgca    420

gtgaaattcc ttgttattgg gaaaatcagc caacaggatg tcaaaaatta aactgcgctt    480

tccatcacaa tagaggacga tatgttgatg gccttttcct acctccgagc aaaagtgtgt    540

tgcccactgt gcctgagtca ccagaagagg aagtgaaggc tagccaactt tcagttcagc    600

agaacaaatt gtctgtccag tccaatactt cccctcagct gcggagcgtt atgaaagtag    660

aaagttccga aaatgttcct agccccaagc atccaccagt tgtaattaat gctgcagatg    720

atgatgaaga tgatgatgat cagttttctg aggaaggtga tgaaaccaaa acacctaccc    780

tgcaaccaac tcctgaagtt cacaatggat tacgagtgac ttctgtccgg aaacctgcag    840

tcaatataaa gcaaggtgaa tgtttgcatt ttggaataaa aactcttgag gaaattaagt    900

caaagaaaat gaaggaaaaa tctgaggagc aaggtgaggg ttcttcagga gtttccagtc    960

ttttactcca ccctgagcct gttccaggtc ctgaaaaaga aaatgtcagg actgtggtga   1020

ggacagtaac tctctccacc aaacaaggag aagaaccctt ggttagattg ggccttactg   1080

agacactggg gaaacgaaaa ttttcgacag gcggtgacag tgatcctcca ttaaagcgca   1140

gcctggcaca gaggctaggg aagaaagttg aagctccaga aactaacact gacgaaacac   1200

caaagaaagc tcaagtttcc aagtctctta aggagcgatt aggcatgtca gctgatccaa   1260

ataatgagga cgcaacagat aaagttaata aagttggtga gatccatgtg aagacattag   1320

aagaaatgct tcttgaaaga gccagtcaga aacatgggga atcgcaaact aaactcaaga   1380

cagaaggacc ttcaaaaact gatgattcta cttcaggagc aagaagctcc tccactatcc   1440

gtatcaaaac cttctctgag gtcctggctg aagaagaaca taggcagcag gaagcagaga   1500

gacaaaaaag caaaaaggat acaacttgca tcaagctaaa gactgatagt gaaattaaaa   1560

aaacagtagt tttgccaccc attgttgcca gcaaaggaca atcagaggag cctgcaggta   1620

aaacaaagtc catgcaggag gtgcacatga agacggtgga agaaattaaa ctggagaagg   1680

cactgagggt gcagcagagc tctgagagca gcaccagctc cccgtctcaa catgaggcca   1740

ctccaggggc aaggttgcta ctgcgaatca ccaaaagaac atggaggaaa gaagagaaga   1800

aacttcagga aggaaatgaa gttgattttc tgagccgtgt tagaatggaa gctacagagg   1860

cttcagttga gaccacagga gttgacatca ctaaaattca agtcaagaga tgtgagatca   1920

tgagagagac gcgcatgcag aaacagcagg agagggaaaa atcagtcttg acacctcttc   1980

agggagatgt agcctcttgc aatacccaag tggcagagaa accagtgctc actgctgtgc   2040

caggaatcac atggcacctg accaagcagc ttcccacaaa gtcatcccag aaggtggagg   2100

tagaaacctc agggattgca gactcattat tgaatgtgaa atggtcagca cagaccttgg   2160

aaaaaagggg tgaagctaaa cccacagtga acgtgaagca atctgtggtt aaagttgtgt   2220

catcccccaa attggcccca aaacgtaagg cagtggagat gcaccctgct gtcactgccg   2280

ctgtgaagcc actcagctcc agcagcgtcc tacaggaacc cccagccaaa aaggcagctg   2340

tggatgctgt tgtcctgctt gtctctgagg acaaatcagt cactgtgcct gaagcagaaa   2400

atcctagaga cagtcttgtg ctgcctccaa cccagtcctc ttcagattcc tcacccccgg   2460

aggtgtctgg cccttcctca tcccaaatga gcatgaaaac tcgccgactc agctctgcct   2520

caacaggaaa gcccccactc tctgtggagg atgattttga gaaactaaca tgggagattt   2580

caggaggcaa attggaagct gagattgacc tggatcctgg gaaagatgaa gatgaccttc   2640

cgcttgagct atgagaaatg attgatagct gaaggtggta gtgaggacac tttaaaaaaa   2700

aaatcgccaa aaaactggac ttagtttcat ctattgtaac atttacctga gatgatcatt   2760

tctttagtct agaatttgcc ccaaatcaga agtatacctc tgaattatct gtatgtgtcc   2820

tggattcctt ggggtcagat ttttaaagtt actttataac cattttgtcc atttgatgcc   2880

attgtttatc atcttttgag aaaaaagttc tgtcataccc ttctctccac aaaaaagaga   2940

ctgagaggga gatcaagtga aagggtgcaa gcaaacttag tgactccttg aggtgtttgt   3000

cagttttggc ttttttctcc tttgttgtat tctttatgta ttgtcttgat gtacttaata   3060

ttacctgagt ttgaaatgga tgaagacagc tgctaccatt aaggaccaaa ttttatgcta   3120

ccactaaaca aaaataccca ctcagtctgt gttaaattgt atgtcttttt aaaggtattt   3180

agagattcaa ctaagcttta aagagggctg agcagctcag gaagcctgta atgtgggcat   3240

aactctttgg acctgatctt gatgcttctg ctgctctgtt ggcctctgaa gagcaatatc   3300

taatttatta ttactgtaat tttttaaaag gctttaaagt gcctcagggg tcccctgaaa   3360

ctaattttct atttctggga ttccctggat tcattatatg agatggtgac atgattagag   3420

gaattctttt ttagtatgaa aattgtccct tttcttcttc agtacttgcc tccttgctgg   3480

cattgaatta acacagggac aaaatttggt taatttttta tttctaattc tcccaacaaa   3540

cccctgttgc ccagtattta tgtggtggcc tttaaccacc tgagggaaaa aatgagctta   3600

ttcaagctgc caatatttat ctatgggctg tagcagtaca ctgaattgta ctgtgccagg   3660

gatattgaga tgctctgggg gtgtattgta tacctgccag ttttcttcat ttctgaattg   3720

agttttcttt tcttgatgtt ggtttccttc atatcacctc aaggtttaga tttgtgaagg   3780

aataagcatg atggaaataa tagtcttgaa aggagatatg ttgtatataa tcaggaggaa   3840

gaggaaggaa ggacttaccc attttgatat tttgctgtag gtggccagtt ttgtttctca   3900

tagggaaatc tgacccacct gtcatgttgg ctcctaagga actgctgttg              3950


<210>  4364
<211>  805
<212>  PRT
<213>  Homosapiens

<400>  4364

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Thr Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320 


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350         


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495     


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510         


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525             


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540                 


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560 


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575     


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590         


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605             


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620                 


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640 


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655     


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670         


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685             


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700                 


Val Val Leu Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Ala 
705                 710                 715                 720 


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Pro Thr Gln Ser Ser Ser 
                725                 730                 735     


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750         


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765             


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780                 


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800 


Leu Pro Leu Glu Leu 
                805 


<210>  4365
<211>  4249
<212>  DNA
<213>  Homosapiens

<400>  4365
cggacggcag cggccaagca agaagaaaga cgtggcagca agcgggagtc ggggatagtg     60

tcatcggttc gggtcccact actttggagc ttgtctcaaa ctccacatac agaaagccac    120

cgaccttatt ccggtatcct acacccattc cccaccctca ttacactccc acccctggcc    180

ctcagcgtgg gagtcaagag caacagggac acttccgtac tccttgtagg attggtgaaa    240

ccgtaatgac gaacacccct aaactcccat aattggattt ggggatattc cctgcccaaa    300

aaattcctgg aaaattgact agtattaagt gcgtaataga ttggaactca gtgaagacac    360

agacgttcct gttgagagca atcagctaat gattacagtt taaagacaat ttctgtgatc    420

aagttgtcat ttggaagatt aaacccattt cacgaggact tggagcctgg tccttgcttt    480

gaggaagcag tggcttgttt caagaagcca cttctgatct aagaatctac ccagcatgcc    540

taatcaagga gaagactgct attttttttt ctattctaca tgtaccaaag gtgacagctg    600

cccattccgt cactgtgaag ctgcactagg caatgaaact gtttgcacat tatggcaaga    660

agggcgctgt tttcgacggg tgtgcaggtt tcggcacatg gagattgata aaaaacgcag    720

tgaaattcct tgttattggg aaaatcagcc aacaggatgt caaaaattaa actgcgcttt    780

ccatcacaat agaggacgat atgttgatgg ccttttccta cctccgagca aaagtgtgtt    840

gcccactgtg cctgagtcac cagaagagga agtgaaggct agccaacttt cagttcagca    900

gaacaaattg tctgtccagt ccaatacttc ccctcagctg cggagcgtta tgaaagtaga    960

aagttccgaa aatgttccta gccccaagca tccaccagtt gtaattaatg ctgcagatga   1020

tgatgaagat gatgatgatc agttttctga ggaaggtgat gaaaccaaaa cacctaccct   1080

gcaaccaact cctgaagttc acaatggatt acgagtgact tctgtccgga aacctgcagt   1140

caatataaag caaggtgaat gtttgcattt tggaataaaa actcttgagg aaattaagtc   1200

aaagaaaatg aaggaaaaat ctgaggagca aggtgagggt tcttcaggag tttccagtct   1260

tttactccac cctgagcctg ttccaggtcc tgaaaaagaa aatgtcagga ctgtggtgag   1320

gacagtaact ctctccacca aacaaggaga agaacccttg gttagattgg gccttactga   1380

gacactgggg aaacgaaaat tttcgacagg cggtgacagt gatcctccat taaagcgcag   1440

cctggcacag aggctaggga agaaagttga agctccagaa actaacactg acgaaacacc   1500

aaagaaagct caagtttcca agtctcttaa ggagcgatta ggcatgtcag ctgatccaaa   1560

taatgaggac gcaacagata aagttaataa agttggtgag atccatgtga agacattaga   1620

agaaatgctt cttgaaagag ccagtcagaa acatggggaa tcgcaaacta aactcaagac   1680

agaaggacct tcaaaaactg atgattctac ttcaggagca agaagctcct ccactatccg   1740

tatcaaaacc ttctctgagg tcctggctga agaagaacat aggcagcagg aagcagagag   1800

acaaaaaagc aaaaaggata caacttgcat caagctaaag actgatagtg aaattaaaaa   1860

aacagtagtt ttgccaccca ttgttgccag caaaggacaa tcagaggagc ctgcaggtaa   1920

aacaaagtcc atgcaggagg tgcacatgaa gacggtggaa gaaattaaac tggagaaggc   1980

actgagggtg cagcagagct ctgagagcag caccagctcc ccgtctcaac atgaggccac   2040

tccaggggca aggttgctac tgcgaatcac caaaagaaca tggaggaaag aagagaagaa   2100

acttcaggaa ggaaatgaag ttgattttct gagccgtgtt agaatggaag ctacagaggc   2160

ttcagttgag accacaggag ttgacatcac taaaattcaa gtcaagagat gtgagatcat   2220

gagagagacg cgcatgcaga aacagcagga gagggaaaaa tcagtcttga cacctcttca   2280

gggagatgta gcctcttgca atacccaagt ggcagagaaa ccagtgctca ctgctgtgcc   2340

aggaatcaca tggcacctga ccaagcagct tcccacaaag tcatcccaga aggtggaggt   2400

agaaacctca gggattgcag actcattatt gaatgtgaaa tggtcagcac agaccttgga   2460

aaaaaggggt gaagctaaac ccacagtgaa cgtgaagcaa tctgtggtta aagttgtgtc   2520

atcccccaaa ttggccccaa aacgtaaggc agtggagatg caccctgctg tcactgccgc   2580

tgtgaagcca ctcagctcca gcagcgtcct acaggaaccc ccagccaaaa aggcagctgt   2640

ggatgctgtt gtcctgcttg tctctgagga caaatcagtc actgtgcctg aagcagaaaa   2700

tcctagagac agtcttgtgc tgcctccaac ccagtcctct tcagattcct cacccccgga   2760

ggtgtctggc ccttcctcat cccaaatgag catgaaaact cgccgactca gctctgcctc   2820

aacaggaaag cccccactct ctgtggagga tgattttgag aaactaacat gggagatttc   2880

aggaggcaaa ttggaagctg agattgacct ggatcctggg aaagatgaag atgaccttcc   2940

gcttgagcta tgagaaatga ttgatagctg aaggtggtag tgaggacact ttaaaaaaaa   3000

aatcgccaaa aaactggact tagtttcatc tattgtaaca tttacctgag atgatcattt   3060

ctttagtcta gaatttgccc caaatcagaa gtatacctct gaattatctg tatgtgtcct   3120

ggattccttg gggtcagatt tttaaagtta ctttataacc attttgtcca tttgatgcca   3180

ttgtttatca tcttttgaga aaaaagttct gtcataccct tctctccaca aaaaagagac   3240

tgagagggag atcaagtgaa agggtgcaag caaacttagt gactccttga ggtgtttgtc   3300

agttttggct tttttctcct ttgttgtatt ctttatgtat tgtcttgatg tacttaatat   3360

tacctgagtt tgaaatggat gaagacagct gctaccatta aggaccaaat tttatgctac   3420

cactaaacaa aaatacccac tcagtctgtg ttaaattgta tgtcttttta aaggtattta   3480

gagattcaac taagctttaa agagggctga gcagctcagg aagcctgtaa tgtgggcata   3540

actctttgga cctgatcttg atgcttctgc tgctctgttg gcctctgaag agcaatatct   3600

aatttattat tactgtaatt ttttaaaagg ctttaaagtg cctcaggggt cccctgaaac   3660

taattttcta tttctgggat tccctggatt cattatatga gatggtgaca tgattagagg   3720

aattcttttt tagtatgaaa attgtccctt ttcttcttca gtacttgcct ccttgctggc   3780

attgaattaa cacagggaca aaatttggtt aattttttat ttctaattct cccaacaaac   3840

ccctgttgcc cagtatttat gtggtggcct ttaaccacct gagggaaaaa atgagcttat   3900

tcaagctgcc aatatttatc tatgggctgt agcagtacac tgaattgtac tgtgccaggg   3960

atattgagat gctctggggg tgtattgtat acctgccagt tttcttcatt tctgaattga   4020

gttttctttt cttgatgttg gtttccttca tatcacctca aggtttagat ttgtgaagga   4080

ataagcatga tggaaataat agtcttgaaa ggagatatgt tgtatataat caggaggaag   4140

aggaaggaag gacttaccca ttttgatatt ttgctgtagg tggccagttt tgtttctcat   4200

agggaaatct gacccacctg tcatgttggc tcctaaggaa ctgctgttg               4249


<210>  4366
<211>  805
<212>  PRT
<213>  Homosapiens

<400>  4366

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Thr Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320 


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350         


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495     


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510         


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525             


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540                 


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560 


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575     


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590         


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605             


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620                 


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640 


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655     


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670         


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685             


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700                 


Val Val Leu Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Ala 
705                 710                 715                 720 


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Pro Thr Gln Ser Ser Ser 
                725                 730                 735     


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750         


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765             


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780                 


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800 


Leu Pro Leu Glu Leu 
                805 


<210>  4367
<211>  926
<212>  DNA
<213>  Homosapiens

<400>  4367
atgcacacat cttctccaag gtttgtgtgc agaacatcct gcccatgctg ccccagcagc     60

ttcagttggc acctgcccca gtccagcctc tgggaaccac gcagcagctc ccagcggccc    120

tgcacccacc accagcatcc gtttcacctg cagttgaaga tccgtgaggt gcccagaaga    180

tcatgcagtc atcagtccca cggagcagcc cgtgaggctg aggctcctcc cactggaccg    240

ccccccgact ggcaccactg ctgcccctgc ccctactctc agcctcacgt gactctcggg    300

cagaggcagt ggtggggcag ccagggcagc gtcaagagtc tgagccagct gcaggacaaa    360

ttcgagcatc ttaaaatgat tcaacaggag gagataagga agctcgagga agagaaaaaa    420

caactggaag gagaaatcat agatttttat aaaatgaaag ctgcctctga agcactgcag    480

actcagctga gcactgatac aaagaaagac aaacatcctg atccatatga attcctctta    540

ttaagaaaaa taaagcatcc aggattcagt gaagaactga ctatcacctt gttaatcatt    600

cagaaacatg ttgcagactt aagccatttt tgatatagat actgaaacaa ttacttgcta    660

agagcaaact tgaaggtatg gataaggccc tgagtcatct tgctgagctg aatgatagtt    720

aagctgaatg tacgtataaa atatgatttt ctaaccactt gctcgccaac aaggaaaact    780

tttaagtaga gcagaacctg aatagacaag acatttcttt cttttggtag aaaatgattt    840

accatcactg tctagttaat tgtagactag gtaattttaa ctttgtgatt tattgccgga    900

gacattttct tctgtactat aaagtg                                         926


<210>  4368
<211>  210
<212>  PRT
<213>  Homosapiens

<400>  4368

Met His Thr Ser Ser Pro Arg Phe Val Cys Arg Thr Ser Cys Pro Cys 
1               5                   10                  15      


Cys Pro Ser Ser Phe Ser Trp His Leu Pro Gln Ser Ser Leu Trp Glu 
            20                  25                  30          


Pro Arg Ser Ser Ser Gln Arg Pro Cys Thr His His Gln His Pro Phe 
        35                  40                  45              


His Leu Gln Leu Lys Ile Arg Glu Val Pro Arg Arg Ser Cys Ser His 
    50                  55                  60                  


Gln Ser His Gly Ala Ala Arg Glu Ala Glu Ala Pro Pro Thr Gly Pro 
65                  70                  75                  80  


Pro Pro Asp Trp His His Cys Cys Pro Cys Pro Tyr Ser Gln Pro His 
                85                  90                  95      


Val Thr Leu Gly Gln Arg Gln Trp Trp Gly Ser Gln Gly Ser Val Lys 
            100                 105                 110         


Ser Leu Ser Gln Leu Gln Asp Lys Phe Glu His Leu Lys Met Ile Gln 
        115                 120                 125             


Gln Glu Glu Ile Arg Lys Leu Glu Glu Glu Lys Lys Gln Leu Glu Gly 
    130                 135                 140                 


Glu Ile Ile Asp Phe Tyr Lys Met Lys Ala Ala Ser Glu Ala Leu Gln 
145                 150                 155                 160 


Thr Gln Leu Ser Thr Asp Thr Lys Lys Asp Lys His Pro Asp Pro Tyr 
                165                 170                 175     


Glu Phe Leu Leu Leu Arg Lys Ile Lys His Pro Gly Phe Ser Glu Glu 
            180                 185                 190         


Leu Thr Ile Thr Leu Leu Ile Ile Gln Lys His Val Ala Asp Leu Ser 
        195                 200                 205             


His Phe 
    210 


<210>  4369
<211>  2868
<212>  DNA
<213>  Homosapiens

<400>  4369
gcacaacctc tgctcactgc agcctccacc tgccaggctc aagcaatgct cctgcctcag     60

cctcccgagt agctgggatt acaggtaagt gccaccacac ccagctgatt tttgtgtttt    120

ttgtagagac gaggtttcgc catgtttccc agactgttct caaactcctg agctcaaagc    180

agtccaccca ccttggcctc ccagagtgct gggattacag gtgtgagcca tcttgctcat    240

tctagtttaa acttttgagt agtttgtgtc tcctgattgg actcctacaa atacagaatt    300

gatgctagga agggtaccag gagatagacg cacacagatg ggatttggga ataggtttgg    360

ttatccaagg agcagtgctg agctccttgc taatgggata tgggatgctg gtgatttcca    420

ggaagtgagc tcacaatgac tcaagctgcc acatagtgtt gattgtgaaa tgccagttga    480

agcatatgtc ctgcgagctt gggggtgcta caagttgacc actgcagcag taaagatgac    540

tctgaagaat ggcgtgggat ggatcctttc aaatgcactt gagcagcagt ctccaaccac    600

agggccacag agctggagct ggatctacca tgaaagactt ctgaatccag gaagagagac    660

tgactgggca acatgttatt caggtgggac catccagttg caggaaaaca agcttaacac    720

gcccactgat tctacattat gctcctacct cccggcagcc tctccaggcc cagaactttc    780

tccagtcagc ctctacagac caagctcatg actcacaatg gcctatttag gcccataccc    840

tacctcacgg cagtctccgc agatgagcct actgcctcac aacagcctcc acaggcacag    900

ctccatcgtt acaatggcct ctttagaccc agctcctgcc tcccagcctt ctctccaggc    960

cctgaacttt ctcaagtcga cctcaccagg cccagctcat gcttctttgc agcctctcca   1020

ggcccaactc ctgcatcttg gtggcccctc caggcccagc ctgtgcctcc cgtcggcctc   1080

tacaatccca acatctgcct cacagcagat tcttcacgcc cagcctctgc ctcacagtgg   1140

accctccaga cccagatggt gtctcactgt ggcatcctca ggcgaagctc ctgcctttca   1200

gcagcctctc caggcccagc tcctcctgcc tcccagtggc ctctttcggc ccagcccagc   1260

tcatgcctcc cggcggcctt cccaagcccc gcttttgact tttggtggcc tctgcaggcc   1320

tcgacaaggc ccagcctcct gcctcccgaa ggcctgcaca ggcccagcct ctgcctcaca   1380

gcggactctc cacgcccagc tagctctcgc ctcactgcgg cctccccagt ccaaagctcc   1440

tgcctttcgg ccacttcggc aggtccagct actgcctgcc agtggcctct ttaggcccag   1500

ctcattcctc acaacggcct ttccaggccc cgtttttccc ttccggcagc ctcttggctt   1560

ctaatttgtt tatcttttgt gtataaatcc caaaatatgg aattttggaa tatttccacc   1620

attatatatt ttggtcggta atttatttgg agtgagtttc tgcaccatgc ccgaattttt   1680

tattttattt tccttattat ttggtgttaa acaggtttaa tgacagtcat ggcaactttt   1740

tggcacaatg aaaaatatcg cccatgatca acgtgttctg ttctggggaa gggggcaaag   1800

gcagggtgaa tcactttctt aaaaagtata gctcaagttg ggagtgcaga gggaatgggg   1860

agaaaaccct cccgctgcct gtgtcgaagt gcaggagccc ccacccccat actcacctga   1920

gtccagcccc tctggggaaa gaaggggtgc atgaactccc cctagtccac aggcgcctcc   1980

ctgtggccca aggccctctt cacactccat cttgtagccc cagcaggagc tattttctga   2040

aaagtgaaaa gctctgaagg tcccacaatt catggtatgt acaggggctc ggaggaggga   2100

aactgcccag ctttcccccg gcacagctgc aggggtaggg ggtatagata agaggagcag   2160

gccttggcca ggcgtggtgg ctcacgcctg taatcccagc actttgggag ggggaggcag   2220

gcagatcacg atgtcaggag atcgaaatca gcctggccaa gatgatgaag ccccgtctgt   2280

actaaaaata caaaaattag ccggacgtgg tagtgtgcac ctgtaatcct agctacccgg   2340

aaggctgagg caggagaatg gcgtgaaccc agcgggaaga ggttgcagtg agccaagatt   2400

gcaccactgc actccagcct gggcaacaga gcaagactcg gtctcaaaaa aaaaaaaaaa   2460

aaaaaaaaaa gaggcaggcc ttactccgtc ccaaactgaa aggattaaat ggctttacct   2520

gggagaagat aaccatcctg ccctccgttg ctaccctcac atactgtcca tgttctcaag   2580

gggtactgtg agtcctggga tctttggggt tgcccacctg cctgtggtag ttatggagac   2640

ccccaggtgt tgaggcaggg ctggggtgtc cccttccaac caggctgtca aggccccaac   2700

tctggggcag aggcagtggc agggcagcca gggttgcgcc agagcctgag cagattgagg   2760

tggggtcagg cagggctggg agtcagggca ggggcagcag cagtggaccc gctatgcaca   2820

catcttctcc aaggtttgtg tgcagaacat cctgcccatg ctgcccca                2868


<210>  4370
<211>  113
<212>  PRT
<213>  Homosapiens

<400>  4370

Met Pro Val Glu Ala Tyr Val Leu Arg Ala Trp Gly Cys Tyr Lys Leu 
1               5                   10                  15      


Thr Thr Ala Ala Val Lys Met Thr Leu Lys Asn Gly Val Gly Trp Ile 
            20                  25                  30          


Leu Ser Asn Ala Leu Glu Gln Gln Ser Pro Thr Thr Gly Pro Gln Ser 
        35                  40                  45              


Trp Ser Trp Ile Tyr His Glu Arg Leu Leu Asn Pro Gly Arg Glu Thr 
    50                  55                  60                  


Asp Trp Ala Thr Cys Tyr Ser Gly Gly Thr Ile Gln Leu Gln Glu Asn 
65                  70                  75                  80  


Lys Leu Asn Thr Pro Thr Asp Ser Thr Leu Cys Ser Tyr Leu Pro Ala 
                85                  90                  95      


Ala Ser Pro Gly Pro Glu Leu Ser Pro Val Ser Leu Tyr Arg Pro Ser 
            100                 105                 110         


Ser 
    


<210>  4371
<211>  749
<212>  DNA
<213>  Homosapiens

<400>  4371
tggggactgg taagagcgac ctccccgcca ggtcctgtgt gttgccggct gaagaagggt     60

agctgaaaaa ttcagaccca gcacagtgtt tatgttggtc aaaaatagaa aactatgtct    120

ggcgcggccg aggcgggagg acccttcagg ccaagagcag cgtagcaaca tggcgcaacc    180

ccatctctgt agtcctacct cagcccccca gctacttgaa cccaaaggtt caaggctcca    240

gtgagctatg atcccaccac agcattccag cctgcgagat tgagatgatg attattcccc    300

accttctaag agacaaagac caacgagcca ccacagccac cagtcccaga acccgccaat    360

gctggggaac ggaaaatgag ggagttcaac tctgagaaat ggaatcatcg tatcgctgat    420

ctacgtaaac aaactgaaga attgtctgaa agaaaatatg acatgaactt atgaattcaa    480

caggtgaaga tttacaactt gataaatcaa ctttgtgagc tcgagctgta aaagccaaag    540

gtctggtgat gatcccatac ccttttttcc agtctcatgt tgaagatttt tatgtagaag    600

gccttcccaa aggaattttt tttttttttt ttttttgaga tggagttttc actcttatcg    660

cccaggctgg ggtgcaatgg cgcaaccttg ctggtcactg caacctctgc ctcctgggtt    720

caagaaattc tcctgcctta gcctcccaa                                      749


<210>  4372
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  4372

Met Arg Glu Phe Asn Ser Glu Lys Trp Asn His Arg Ile Ala Asp Leu 
1               5                   10                  15      


Arg Lys Gln Thr Glu Glu Leu Ser Glu Arg Lys Tyr Asp Met Asn Leu 
            20                  25                  30          


<210>  4373
<211>  1431
<212>  DNA
<213>  Homosapiens

<400>  4373
agctgcagtc tgggagtctt tggagtaaga atggccttgg aagggatgag caaacggaag     60

agaaagagaa gtgtccagga gggagagaat cctgacgacg gcgttcgcgg gagtccgccg    120

gaagactaca ggcttggaca ggtcgccagt agcttatttc gcggcgaaca ccattccaga    180

ggtggcaccg gtcggctggc gtccctcttc agttctctgg agccccagat tcaacccgtg    240

tacgtgcctg tgcctaaaca aaccatcaaa aaaacgaaac ggaatgagga ggaagaaagt    300

acatcccaga ttgaaagacc actttcgcaa gaacctgcca aaaaagtgaa agcgaagaag    360

aaacacacta acgcagaaaa aaagttggca gacagggaaa gcgctctagc gagtgctgat    420

ttagaagaag aaattcacca gaaacaaggg cagaaaagga aaaattctca acctggtgtt    480

aaagtagcag atagaaaaat acttgatgac acagaagaca cagttgtcag tcaaagaaag    540

aaaattcaaa tcaaccaaga agaagagaga ttaaagaatg agagaactgt gtttgttggg    600

aatttgcctg ttacatgtaa taagaagaag ctgaagtcgt tttttaaaga gtatggacaa    660

atagaatctg tacgatttcg ttctctgatt ccagcagagg gaacgctatc caaaaagttg    720

gcagcaataa aacgtaaaat tcatcctgat cagaaaaata ttaatgccta tgttgtgttt    780

aaggaggaga gtgctgccac gcaagcattg aaaagaaatg gggcccagat tgcagatgga    840

tttcgtatta gagttgatct cgcatctgag acctcatcta gagacaagag atcggttttt    900

gtggggaatc tcccttataa agttgaagaa tctgccattg agaagcactt tctggactgt    960

ggaagtatca tggccgtgag gattgtgaga gacaaaatga caggcatcgg caaagggttt   1020

ggctatgtgc tctttgagaa tacagattct gttcatcttg ctctgaaatt aaataattct   1080

gaactcatgg ggagaaaact cagagtcatg cgttctgtta ataaagaaaa atttaaacaa   1140

caaaattcaa atccacgatt gaagaatgtc agtaaaccta agcagggact taattttact   1200

tccaaaactg cagaaggaca tcctaaaagc ttatttattg gagaaaaagc tgttctcctt   1260

aaaacgaaga agaaaggaca gaagaaaagt ggacgcccta agaaacagag aaaacagaaa   1320

taacaaccag gaactgcttt ttcttttcct gctgagtact gctaataaaa gtgctattat   1380

ctgctgatag catcgtctgc taaaaaaaaa aaaaaaaaaa aaaaaaaaaa a            1431


<210>  4374
<211>  425
<212>  PRT
<213>  Homosapiens

<400>  4374

Met Ser Lys Arg Lys Arg Lys Arg Ser Val Gln Glu Gly Glu Asn Pro 
1               5                   10                  15      


Asp Asp Gly Val Arg Gly Ser Pro Pro Glu Asp Tyr Arg Leu Gly Gln 
            20                  25                  30          


Val Ala Ser Ser Leu Phe Arg Gly Glu His His Ser Arg Gly Gly Thr 
        35                  40                  45              


Gly Arg Leu Ala Ser Leu Phe Ser Ser Leu Glu Pro Gln Ile Gln Pro 
    50                  55                  60                  


Val Tyr Val Pro Val Pro Lys Gln Thr Ile Lys Lys Thr Lys Arg Asn 
65                  70                  75                  80  


Glu Glu Glu Glu Ser Thr Ser Gln Ile Glu Arg Pro Leu Ser Gln Glu 
                85                  90                  95      


Pro Ala Lys Lys Val Lys Ala Lys Lys Lys His Thr Asn Ala Glu Lys 
            100                 105                 110         


Lys Leu Ala Asp Arg Glu Ser Ala Leu Ala Ser Ala Asp Leu Glu Glu 
        115                 120                 125             


Glu Ile His Gln Lys Gln Gly Gln Lys Arg Lys Asn Ser Gln Pro Gly 
    130                 135                 140                 


Val Lys Val Ala Asp Arg Lys Ile Leu Asp Asp Thr Glu Asp Thr Val 
145                 150                 155                 160 


Val Ser Gln Arg Lys Lys Ile Gln Ile Asn Gln Glu Glu Glu Arg Leu 
                165                 170                 175     


Lys Asn Glu Arg Thr Val Phe Val Gly Asn Leu Pro Val Thr Cys Asn 
            180                 185                 190         


Lys Lys Lys Leu Lys Ser Phe Phe Lys Glu Tyr Gly Gln Ile Glu Ser 
        195                 200                 205             


Val Arg Phe Arg Ser Leu Ile Pro Ala Glu Gly Thr Leu Ser Lys Lys 
    210                 215                 220                 


Leu Ala Ala Ile Lys Arg Lys Ile His Pro Asp Gln Lys Asn Ile Asn 
225                 230                 235                 240 


Ala Tyr Val Val Phe Lys Glu Glu Ser Ala Ala Thr Gln Ala Leu Lys 
                245                 250                 255     


Arg Asn Gly Ala Gln Ile Ala Asp Gly Phe Arg Ile Arg Val Asp Leu 
            260                 265                 270         


Ala Ser Glu Thr Ser Ser Arg Asp Lys Arg Ser Val Phe Val Gly Asn 
        275                 280                 285             


Leu Pro Tyr Lys Val Glu Glu Ser Ala Ile Glu Lys His Phe Leu Asp 
    290                 295                 300                 


Cys Gly Ser Ile Met Ala Val Arg Ile Val Arg Asp Lys Met Thr Gly 
305                 310                 315                 320 


Ile Gly Lys Gly Phe Gly Tyr Val Leu Phe Glu Asn Thr Asp Ser Val 
                325                 330                 335     


His Leu Ala Leu Lys Leu Asn Asn Ser Glu Leu Met Gly Arg Lys Leu 
            340                 345                 350         


Arg Val Met Arg Ser Val Asn Lys Glu Lys Phe Lys Gln Gln Asn Ser 
        355                 360                 365             


Asn Pro Arg Leu Lys Asn Val Ser Lys Pro Lys Gln Gly Leu Asn Phe 
    370                 375                 380                 


Thr Ser Lys Thr Ala Glu Gly His Pro Lys Ser Leu Phe Ile Gly Glu 
385                 390                 395                 400 


Lys Ala Val Leu Leu Lys Thr Lys Lys Lys Gly Gln Lys Lys Ser Gly 
                405                 410                 415     


Arg Pro Lys Lys Gln Arg Lys Gln Lys 
            420                 425 


<210>  4375
<211>  2757
<212>  DNA
<213>  Homosapiens

<400>  4375
gggcaatggc gggcgcccct cccccagcct cgttgccgcc ttgcagtttg atctcagact     60

gctgtgctag caatcagcga gactccgtgg gcgtaggacc ctccgagcca ggtgtgggat    120

atagtctcgt ggtgcgccgt ttcttaagct ggtctgaaaa gcgcaatatt cgggtgggag    180

tgacccgatt ttccaggtgc ttccgtcacc cctttctttg actcggaaag ggaactccct    240

gaccccttgc gcttcccagg tgaggcaatg cctcgccctg cttcggctcg cgcacggtgc    300

gcgcacacac tggcctgcgc ccactgtcta gcactcccta gtgagatgaa cccggtacct    360

cagatggaaa tgcagaaatc acccgtcttc tgcgtcgctc acgctgggag ctgtagaccg    420

gagctgttcc tattcggcca tcttggctcc tagtattttt aattaagcac ttgtgttctg    480

attagtggcc aaataaatga cagtcagaac ttcagctaag gtacaataag gttttgctgt    540

ggcgtggcac ctggtctctt tctagaagga aagttcaaca tacagcacaa ttctggacac    600

attgtattgg tttgatgctc ctacctggaa caggtggagc tggtctcttg ggcagcctga    660

catctggtcc actcctctgt cctatgccgg gatcatcatg accgtagaga ttatgtcact    720

gttttgcatc cttgttacat aactcagttc ctggtagatt actatgtcag agagtcacaa    780

tgaccttgca caataacagt acaacctcgc ctttgtttcc aaacatcagc tcctcctgga    840

tacacagccc ctccgatgca gggctgcccc cgggaaccgt cactcatttc ggcagctaca    900

atgtttctcg agcagctggc aatttctcct ctccagacgg taccaccgat gaccctctgg    960

gaggtcatac cgtctggcaa gtggtcttca tcgctttctt aacgggcatc ctggccttgg   1020

tgaccatcat cggcaacatc ctggtaattg tgtcatttaa ggtcaacaag cagctgaaga   1080

cggtcaacaa ctacttcctc ttaagcctgg cctgtgccga tctgattatc ggggtcattt   1140

caatgaatct gtttacgacc tacatcatca tgaatcgatg ggccttaggg aacttggcct   1200

gtgacctctg gcttgccatt gactacgtag ccagcaatgc ctctgttatg aatcttctgg   1260

tcatcagctt tgacagatac ttttccatca cgaggccgct cacgtaccga gccaaacgaa   1320

caacaaagag agccggtgtg atgatcggtc tggcttgggt catctccttt gtcctttggg   1380

ctcctgccat cttgttctgg caatactttg ttggaaagag aactgtgcct ccgggagagt   1440

gcttcattca gttcctcagt gagcccacca ttacttttgg cacagccatc gctgcttttt   1500

atatgcctgt caccattatg actattttat actggaggat ctataaggaa actgaaaagc   1560

gtaccaaaga gcttgctggc ctgcaagcct ctgggacaga ggcagagaca gaaaactttg   1620

tccaccccac gggcagttct cgaagctgca gcagttacga acttcaacag caaagcatga   1680

aacgctccaa caggaggaag tatggccgct gccacttctg gttcacaacc aagagctgga   1740

aacccagctc cgagcagatg gaccaagacc acagcagcag tgacagttgg aacaacaatg   1800

atgctgctgc ctccctggag aactccgcct cctccgacga ggaggacatt ggctccgaga   1860

cgagagccat ctactccatc gtgctcaagc ttccgggtca cagcaccatc ctcaactcca   1920

ccaagttacc ctcatcggac aacctgcagg tgcctgagga ggagctgggg atggtggact   1980

tggagaggaa agccgacaag ctgcaggccc agaagagcgt ggacgatgga ggcagttttc   2040

caaaaagctt ctccaagctt cccatccagc tagagtcagc cgtggacaca gctaagactt   2100

ctgacgtcaa ctcctcagtg ggtaagagca cggccactct acctctgtcc ttcaaggaag   2160

ccactctggc caagaggttt gctctgaaga ccagaagtca gatcactaag cggaaaagga   2220

tgtccctggt caaggagaag aaagcggccc agaccctcag tgcgatcttg cttgccttca   2280

tcatcacttg gaccccatac aacatcatgg ttctggtgaa caccttttgt gacagctgca   2340

tacccaaaac cttttggaat ctgggctact ggctgtgcta catcaacagc accgtgaacc   2400

ccgtgtgcta tgctctgtgc aacaaaacat tcagaaccac tttcaagatg ctgctgctgt   2460

gccagtgtga caaaaaaaag aggcgcaagc agcagtacca gcagagacag tcggtcattt   2520

ttcacaagcg cgcacccgag caggccttgt agaatgaggt tgtatcaata gcagtgacaa   2580

aacgcacaca tcaacccaca gaccttagga ggaggaaggc gagggcgggg tgacttctgg   2640

tgatgataaa aatggtttta tcacccagat gtgaaagaag ctgcctgttt actgatccat   2700

tgaataaacc cattttaata gaaaaagtca ataccaattc agcaaaaaaa aaaaaaa      2757


<210>  4376
<211>  590
<212>  PRT
<213>  Homosapiens

<400>  4376

Met Thr Leu His Asn Asn Ser Thr Thr Ser Pro Leu Phe Pro Asn Ile 
1               5                   10                  15      


Ser Ser Ser Trp Ile His Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly 
            20                  25                  30          


Thr Val Thr His Phe Gly Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn 
        35                  40                  45              


Phe Ser Ser Pro Asp Gly Thr Thr Asp Asp Pro Leu Gly Gly His Thr 
    50                  55                  60                  


Val Trp Gln Val Val Phe Ile Ala Phe Leu Thr Gly Ile Leu Ala Leu 
65                  70                  75                  80  


Val Thr Ile Ile Gly Asn Ile Leu Val Ile Val Ser Phe Lys Val Asn 
                85                  90                  95      


Lys Gln Leu Lys Thr Val Asn Asn Tyr Phe Leu Leu Ser Leu Ala Cys 
            100                 105                 110         


Ala Asp Leu Ile Ile Gly Val Ile Ser Met Asn Leu Phe Thr Thr Tyr 
        115                 120                 125             


Ile Ile Met Asn Arg Trp Ala Leu Gly Asn Leu Ala Cys Asp Leu Trp 
    130                 135                 140                 


Leu Ala Ile Asp Tyr Val Ala Ser Asn Ala Ser Val Met Asn Leu Leu 
145                 150                 155                 160 


Val Ile Ser Phe Asp Arg Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr 
                165                 170                 175     


Arg Ala Lys Arg Thr Thr Lys Arg Ala Gly Val Met Ile Gly Leu Ala 
            180                 185                 190         


Trp Val Ile Ser Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln 
        195                 200                 205             


Tyr Phe Val Gly Lys Arg Thr Val Pro Pro Gly Glu Cys Phe Ile Gln 
    210                 215                 220                 


Phe Leu Ser Glu Pro Thr Ile Thr Phe Gly Thr Ala Ile Ala Ala Phe 
225                 230                 235                 240 


Tyr Met Pro Val Thr Ile Met Thr Ile Leu Tyr Trp Arg Ile Tyr Lys 
                245                 250                 255     


Glu Thr Glu Lys Arg Thr Lys Glu Leu Ala Gly Leu Gln Ala Ser Gly 
            260                 265                 270         


Thr Glu Ala Glu Thr Glu Asn Phe Val His Pro Thr Gly Ser Ser Arg 
        275                 280                 285             


Ser Cys Ser Ser Tyr Glu Leu Gln Gln Gln Ser Met Lys Arg Ser Asn 
    290                 295                 300                 


Arg Arg Lys Tyr Gly Arg Cys His Phe Trp Phe Thr Thr Lys Ser Trp 
305                 310                 315                 320 


Lys Pro Ser Ser Glu Gln Met Asp Gln Asp His Ser Ser Ser Asp Ser 
                325                 330                 335     


Trp Asn Asn Asn Asp Ala Ala Ala Ser Leu Glu Asn Ser Ala Ser Ser 
            340                 345                 350         


Asp Glu Glu Asp Ile Gly Ser Glu Thr Arg Ala Ile Tyr Ser Ile Val 
        355                 360                 365             


Leu Lys Leu Pro Gly His Ser Thr Ile Leu Asn Ser Thr Lys Leu Pro 
    370                 375                 380                 


Ser Ser Asp Asn Leu Gln Val Pro Glu Glu Glu Leu Gly Met Val Asp 
385                 390                 395                 400 


Leu Glu Arg Lys Ala Asp Lys Leu Gln Ala Gln Lys Ser Val Asp Asp 
                405                 410                 415     


Gly Gly Ser Phe Pro Lys Ser Phe Ser Lys Leu Pro Ile Gln Leu Glu 
            420                 425                 430         


Ser Ala Val Asp Thr Ala Lys Thr Ser Asp Val Asn Ser Ser Val Gly 
        435                 440                 445             


Lys Ser Thr Ala Thr Leu Pro Leu Ser Phe Lys Glu Ala Thr Leu Ala 
    450                 455                 460                 


Lys Arg Phe Ala Leu Lys Thr Arg Ser Gln Ile Thr Lys Arg Lys Arg 
465                 470                 475                 480 


Met Ser Leu Val Lys Glu Lys Lys Ala Ala Gln Thr Leu Ser Ala Ile 
                485                 490                 495     


Leu Leu Ala Phe Ile Ile Thr Trp Thr Pro Tyr Asn Ile Met Val Leu 
            500                 505                 510         


Val Asn Thr Phe Cys Asp Ser Cys Ile Pro Lys Thr Phe Trp Asn Leu 
        515                 520                 525             


Gly Tyr Trp Leu Cys Tyr Ile Asn Ser Thr Val Asn Pro Val Cys Tyr 
    530                 535                 540                 


Ala Leu Cys Asn Lys Thr Phe Arg Thr Thr Phe Lys Met Leu Leu Leu 
545                 550                 555                 560 


Cys Gln Cys Asp Lys Lys Lys Arg Arg Lys Gln Gln Tyr Gln Gln Arg 
                565                 570                 575     


Gln Ser Val Ile Phe His Lys Arg Ala Pro Glu Gln Ala Leu 
            580                 585                 590 


<210>  4377
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  4377
atggaaaatt acaatcaaac atcaactgat ttcatcttat tggggctgtt tccaccatca     60

agaattgacc ttttcttctt cattctcatt gttttcattt tcctgatggc tctaattgga    120

aacctgtcca tgattcttct catcttcttg gacacccatc tccacacacc catgtatttc    180

ctactgagtc agctctccct cattgaccta aattacatct ccaccattgt tcctaagatg    240

gcatctgatt ttctgcatgg aaacaagtct atctccttca ctgggtgtgg gattcagagt    300

ttcttcttct tggcattagg aggtgcagaa gcactacttt tggcatctat ggcctatgat    360

cgttacattg ctatttgctt tcctctccac tatctcatcc gcatgagcaa aagagtgtgt    420

gtgctgatga taacagggtc ttggatcata ggctcgatca atgcttgtgc tcacactgta    480

tatgtactcc atattcctta ttgccgatcc agggccatca atcatttctt ctgtgatgtc    540

ccagcaatgg tgactctggc ctgcatggac acctgggtct atgagggcac agtgtttttg    600

agtgccacca tctttctcgt gtttcccttc attggtattt catgttccta tggccaggtt    660

ctctttgctg tctaccacat gaaatctgca gaagggagga agaaagccta tttgacctgc    720

agcacccacc tcactgtagt aactttctac tatgcacctt ttgtctacac ttatctacgt    780

ccaagatccc tgcgatctcc aacagaggac aaggttctgg ctgtcttcta caccatcctc    840

accccaatgc tcaaccccat catctatagc ctgaggaaca aggaggtgat gggggccctg    900

acacgagtga gtcagagaat ctgctctgtg aaaatgtag                           939


<210>  4378
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  4378

Met Glu Asn Tyr Asn Gln Thr Ser Thr Asp Phe Ile Leu Leu Gly Leu 
1               5                   10                  15      


Phe Pro Pro Ser Arg Ile Asp Leu Phe Phe Phe Ile Leu Ile Val Phe 
            20                  25                  30          


Ile Phe Leu Met Ala Leu Ile Gly Asn Leu Ser Met Ile Leu Leu Ile 
        35                  40                  45              


Phe Leu Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 
    50                  55                  60                  


Leu Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met 
65                  70                  75                  80  


Ala Ser Asp Phe Leu His Gly Asn Lys Ser Ile Ser Phe Thr Gly Cys 
                85                  90                  95      


Gly Ile Gln Ser Phe Phe Phe Leu Ala Leu Gly Gly Ala Glu Ala Leu 
            100                 105                 110         


Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Phe Pro 
        115                 120                 125             


Leu His Tyr Leu Ile Arg Met Ser Lys Arg Val Cys Val Leu Met Ile 
    130                 135                 140                 


Thr Gly Ser Trp Ile Ile Gly Ser Ile Asn Ala Cys Ala His Thr Val 
145                 150                 155                 160 


Tyr Val Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asn His Phe 
                165                 170                 175     


Phe Cys Asp Val Pro Ala Met Val Thr Leu Ala Cys Met Asp Thr Trp 
            180                 185                 190         


Val Tyr Glu Gly Thr Val Phe Leu Ser Ala Thr Ile Phe Leu Val Phe 
        195                 200                 205             


Pro Phe Ile Gly Ile Ser Cys Ser Tyr Gly Gln Val Leu Phe Ala Val 
    210                 215                 220                 


Tyr His Met Lys Ser Ala Glu Gly Arg Lys Lys Ala Tyr Leu Thr Cys 
225                 230                 235                 240 


Ser Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Val Tyr 
                245                 250                 255     


Thr Tyr Leu Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Val 
            260                 265                 270         


Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Thr Arg Val Ser 
    290                 295                 300                 


Gln Arg Ile Cys Ser Val Lys Met 
305                 310         


<210>  4379
<211>  312
<212>  DNA
<213>  Homosapiens

<400>  4379
atgaaaatat caacaataac gggagtttgg aggaagttga tttccacctt catgaattac     60

tttgagaggt tcaagacttc cttggaggaa gtagctgaag atgtggatga aatagcaaca    120

gaactagaat tagaagtgga gcctgaagat gtgactgaat tgcttcaatc tcatgatgaa    180

actttaaccg ataaggagtt agtttttgta ggtgagcaaa ggaagaggtt tatggagata    240

aaatttactc ctcccgaaga tgttgtgaac gttcttgaaa tgacaacaaa gatattacat    300

caacttagtt ga                                                        312


<210>  4380
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  4380

Met Lys Ile Ser Thr Ile Thr Gly Val Trp Arg Lys Leu Ile Ser Thr 
1               5                   10                  15      


Phe Met Asn Tyr Phe Glu Arg Phe Lys Thr Ser Leu Glu Glu Val Ala 
            20                  25                  30          


Glu Asp Val Asp Glu Ile Ala Thr Glu Leu Glu Leu Glu Val Glu Pro 
        35                  40                  45              


Glu Asp Val Thr Glu Leu Leu Gln Ser His Asp Glu Thr Leu Thr Asp 
    50                  55                  60                  


Lys Glu Leu Val Phe Val Gly Glu Gln Arg Lys Arg Phe Met Glu Ile 
65                  70                  75                  80  


Lys Phe Thr Pro Pro Glu Asp Val Val Asn Val Leu Glu Met Thr Thr 
                85                  90                  95      


Lys Ile Leu His Gln Leu Ser 
            100             


<210>  4381
<211>  528
<212>  DNA
<213>  Homosapiens

<400>  4381
gatacccatc ctgagctgtt tatgtccttg tgcctctctt cacaaacctg ctggtctccc     60

tctgccacct gggatgcagt gcagtggcct gaccacaggt tcaaggaaaa gttagtggaa    120

gccgttatcc atgtcaacat tgaaccagaa ggttctggga tacatgtgca gaatgtgcag    180

agcatgattt gcaagaggaa ctgctacaca ttttacactt atttactcca acctttcctg    240

ctaattccag gtttattgta aaaccactga tcccttcatt tgagctcgac ttccctgcac    300

ttagttttga atttttcccc tgtccaatag taagacacac acacagagaa gaacaacaag    360

aacaagaaga gaattgcaat gatgtgaagt aatgtatatg ttaattagct tgaattagct    420

tgattgtggt gattatttca caatgtacat gtatatcaga tcataaactt gtatatctta    480

aatgaataca acttttattt gtcaattata cctcattcga gctggaaa                 528


<210>  4382
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  4382

Met Ser Leu Cys Leu Ser Ser Gln Thr Cys Trp Ser Pro Ser Ala Thr 
1               5                   10                  15      


Trp Asp Ala Val Gln Trp Pro Asp His Arg Phe Lys Glu Lys Leu Val 
            20                  25                  30          


Glu Ala Val Ile His Val Asn Ile Glu Pro Glu Gly Ser Gly Ile His 
        35                  40                  45              


Val Gln Asn Val Gln Ser Met Ile Cys Lys Arg Asn Cys Tyr Thr Phe 
    50                  55                  60                  


Tyr Thr Tyr Leu Leu Gln Pro Phe Leu Leu Ile Pro Gly Leu Leu 
65                  70                  75                  


<210>  4383
<211>  1312
<212>  DNA
<213>  Homosapiens

<400>  4383
agccggctgc agggcggtga ttcgcccccg ggatggtggc ggcgattccg tgcgccttcc     60

tgcagttgga catcagttat atttcaggct ttcaaagtaa acgacgaact cagcactttg    120

gcagagtcca aaatccgcca gcgaacttgg gtgctagagt tcggcgggaa gaaaagcgcc    180

cgggctgcgc cgaccgccgg ccccgagccg ccgcgggctc cgaggagtcg gccgagctgc    240

tcccgcgccc tggccggacg tttgaaacta ttgctttgct gaaaacatct gactgccagg    300

ctaggatgtg acacttaagg gacttaccaa tttgggattc ttccaggagc tgaaaactga    360

ttgcaaatat gaaacagatt tcactacagg acttgaaccc tacattaaaa aacaacaagc    420

tccccaaaat aattgaaaaa gatcttcacc aaagagtagc tgcaatgtga atggcaggat    480

atgaagcaag taagagatgg tgaaaagatt atcttaagct tggaattaag tgatgaaagg    540

gaccttcgaa attatcaact ctaaatactt ctttacagga aaattgaaag cagttaagaa    600

cctgccccct accgtggagt tcttggtgcc gtgagttgga gttcttggtg cctgggtgcg    660

tccccaaggc cactggtctt cagatctttc ttacttgaga agaacgcctc cgcctcctgg    720

ctctcccacc agtggtattg ccaccaccac acaccagcat aaagcacaga ttgctgccca    780

gctccttgga gaggggccag tgcatttgtc aggaattgaa aagttttgga gccagttcga    840

ggactttctc ctgcacaaag tgttggctgg aagcatgaag caataacaca tggtttgcca    900

aagaatctgc attgaataat actggtggtg accacaagaa catgcctctc tgactgcaag    960

gaacaagagt gacccagggt ttcagctgct gccttggaaa ttcatcacag tgcaagtcta   1020

tgcttcccac gggctgctcc cagcctgtga ataagcctgg catctttgtt gaggcaggcc   1080

tatttctgga gatgcaggat cctccgatgg gcgaatttgg ctctaggact gcttgatggc   1140

cttgacagac tttccttaga aatgcatggc aatttagggt tcctccaccc ttccctcttt   1200

ctctccttca cctagggtcg gacttgcatc atggcctgaa agctccacca gcctctcctg   1260

ccctcctcct cattttcttt cacaggcata tcctctaata aatttcttgc ac           1312


<210>  4384
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  4384

Met Val Ala Ala Ile Pro Cys Ala Phe Leu Gln Leu Asp Ile Ser Tyr 
1               5                   10                  15      


Ile Ser Gly Phe Gln Ser Lys Arg Arg Thr Gln His Phe Gly Arg Val 
            20                  25                  30          


Gln Asn Pro Pro Ala Asn Leu Gly Ala Arg Val Arg Arg Glu Glu Lys 
        35                  40                  45              


Arg Pro Gly Cys Ala Asp Arg Arg Pro Arg Ala Ala Ala Gly Ser Glu 
    50                  55                  60                  


Glu Ser Ala Glu Leu Leu Pro Arg Pro Gly Arg Thr Phe Glu Thr Ile 
65                  70                  75                  80  


Ala Leu Leu Lys Thr Ser Asp Cys Gln Ala Arg Met 
                85                  90          


<210>  4385
<211>  249
<212>  DNA
<213>  Homosapiens

<400>  4385
atgatatttt tgcatgaggt tttccagctt ctgggtggaa acatcttggt ggccaccgat     60

gcagctggag ggctcaaccc caagtctgag gttggaagga tcatgcttct ctgtgatcac    120

atcaagctac ttggtttctg tgatcagaac tctcccaaag ggcccaatga tgaaaggttt    180

ggagttcatt ttcctgccac gtctgatgcc tacaactgga caatgaagca aaaggcgctc    240

aattcttag                                                            249


<210>  4386
<211>  82
<212>  PRT
<213>  Homosapiens

<400>  4386

Met Ile Phe Leu His Glu Val Phe Gln Leu Leu Gly Gly Asn Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ala Ala Gly Gly Leu Asn Pro Lys Ser Glu Val Gly 
            20                  25                  30          


Arg Ile Met Leu Leu Cys Asp His Ile Lys Leu Leu Gly Phe Cys Asp 
        35                  40                  45              


Gln Asn Ser Pro Lys Gly Pro Asn Asp Glu Arg Phe Gly Val His Phe 
    50                  55                  60                  


Pro Ala Thr Ser Asp Ala Tyr Asn Trp Thr Met Lys Gln Lys Ala Leu 
65                  70                  75                  80  


Asn Ser 
        


<210>  4387
<211>  249
<212>  DNA
<213>  Homosapiens

<400>  4387
atgatatttt tgcatgaggt tttccagctt ctgggtggaa acatcttggt ggccaccgat     60

gcagctggag ggctcaaccc caagtctgag gttggaagga tcatgcttct ctgtgatcac    120

atcaagctac ttggtttctg tgatcagaac tctcccaaag ggcccaatga tgaaaggttt    180

ggagttcatt ttcctgccac gtctgatgcc tacaactgga caatgaagca aaaggcgctc    240

aattcttag                                                            249


<210>  4388
<211>  82
<212>  PRT
<213>  Homosapiens

<400>  4388

Met Ile Phe Leu His Glu Val Phe Gln Leu Leu Gly Gly Asn Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ala Ala Gly Gly Leu Asn Pro Lys Ser Glu Val Gly 
            20                  25                  30          


Arg Ile Met Leu Leu Cys Asp His Ile Lys Leu Leu Gly Phe Cys Asp 
        35                  40                  45              


Gln Asn Ser Pro Lys Gly Pro Asn Asp Glu Arg Phe Gly Val His Phe 
    50                  55                  60                  


Pro Ala Thr Ser Asp Ala Tyr Asn Trp Thr Met Lys Gln Lys Ala Leu 
65                  70                  75                  80  


Asn Ser 
        


<210>  4389
<211>  724
<212>  DNA
<213>  Homosapiens

<400>  4389
tgcttgtgat taaataaccc caactgacgt ggaaatcaaa taaagcaaca aagaactgct     60

ttttcaacta acaaaatata cagctggatg tttgtcacaa ttctaatgtc cctgcaaaga    120

tgagatgcat gaatcacaca gcaatctcat caaaaaggaa tttctggaag gcataggaga    180

agagaatcct ggaaaaagca agaagcagga agataagagg caaagaagaa gagagcccca    240

cccactgggg caagctgggg ccccagatga tgaaactgtg gcccagaaag tttaagggat    300

gtgtcaaatg tcacacagct cacagatcca gggacatggc ttaaatccag atatcttgat    360

tctaacttca gttgaggaag agaaagagtg ctgccccacg ctgcctgatt tacaacgtga    420

agtgaaatct ttgaaaagaa aaataagaca atgtcactca agctcttatc tgaggatttc    480

ctgggtttga agacagagct caaactcata caaggggtca tctgagtctg cagataggct    540

tgctttatgc tgctccgtca gatctcttct aaagattagt gcgcaattct ggacattaca    600

ttttaatggt aacatggatt caactaaagg gtaagcaaag gacaccgaca ggaataggga    660

gggtgccatt tatagagaaa agactgagag gtccatattg ttattttacc tgaaagatat    720

aata                                                                 724


<210>  4390
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  4390

Met His Glu Ser His Ser Asn Leu Ile Lys Lys Glu Phe Leu Glu Gly 
1               5                   10                  15      


Ile Gly Glu Glu Asn Pro Gly Lys Ser Lys Lys Gln Glu Asp Lys Arg 
            20                  25                  30          


Gln Arg Arg Arg Glu Pro His Pro Leu Gly Gln Ala Gly Ala Pro Asp 
        35                  40                  45              


Asp Glu Thr Val Ala Gln Lys Val 
    50                  55      


<210>  4391
<211>  724
<212>  DNA
<213>  Homosapiens

<400>  4391
tgcttgtgat taaataaccc caactgacgt ggaaatcaaa taaagcaaca aagaactgct     60

ttttcaacta acaaaatata cagctggatg tttgtcacaa ttctaatgtc cctgcaaaga    120

tgagatgcat gaatcacaca gcaatctcat caaaaaggaa tttctggaag gcataggaga    180

agagaatcct ggaaaaagca agaagcagga agataagagg caaagaagaa gagagcccca    240

cccactgggg caagctgggg ccccagatga tgaaactgtg gcccagaaag tttaagggat    300

gtgtcaaatg tcacacagct cacagatcca gggacatggc ttaaatccag atatcttgat    360

tctaacttca gttgaggaag agaaagagtg ctgccccacg ctgcctgatt tacaacgtga    420

agtgaaatct ttgaaaagaa aaataagaca atgtcactca agctcttatc tgaggatttc    480

ctgggtttga agacagagct caaactcata caaggggtca tctgagtctg cagataggct    540

tgctttatgc tgctccgtca gatctcttct aaagattagt gcgcaattct ggacattaca    600

ttttaatggt aacatggatt caactaaagg gtaagcaaag gacaccgaca ggaataggga    660

gggtgccatt tatagagaaa agactgagag gtccatattg ttattttacc tgaaagatat    720

aata                                                                 724


<210>  4392
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  4392

Met His Glu Ser His Ser Asn Leu Ile Lys Lys Glu Phe Leu Glu Gly 
1               5                   10                  15      


Ile Gly Glu Glu Asn Pro Gly Lys Ser Lys Lys Gln Glu Asp Lys Arg 
            20                  25                  30          


Gln Arg Arg Arg Glu Pro His Pro Leu Gly Gln Ala Gly Ala Pro Asp 
        35                  40                  45              


Asp Glu Thr Val Ala Gln Lys Val 
    50                  55      


<210>  4393
<211>  1257
<212>  DNA
<213>  Homosapiens

<400>  4393
atgatacgag tcattggact taggtcccac cctaaaccca gactaatctc attaggagat     60

taccaagaca tcaaagtggc tttgcctaga agccaaggcc attggtccaa cgcagacatc    120

ttgaggttac tggaatgcat ggagaataat ctcccatatg atgacaacgg cacgttcagc    180

tcaactcagt cacacatgga ctggggaaaa gtagctttta aaaacttttc tggtgaaatg    240

tgcagactca aatggttaga gatttcttgc agcttgagaa aattcagcac tttgaaaaaa    300

ttagtcctgg aagctaagaa atgtgttaaa aatacaaaca aaagccaaaa aggcaggaac    360

catccagact ttccaaagag gctccttact gcttatatcc gcttcttcaa ggagaattgg    420

ccccagtact cccaaatgta ccctgggatg agaagccagg aagtgaccaa aatcctgtca    480

aagaaataca aggagctccc agagcagatg aaacagaaac atattcagga tttccggaag    540

gaaaagcaag aatttgagga aaaacttgct cgattcaggg aagaacaccc tgatttagac    600

cagaagggca agaaatctga tatctgcaag agggttcaaa ccaaagtgca aaagaaggtt    660

cagaaaaata ttgaagaagt gaggtctctt ccaaaaacgg atcaattttt caagaaggta    720

aaatttcatg gagagcctca gaaacccccc atgaatggat accagaagtt tcaccaagat    780

tcctggtcaa gtaaggagct gcaacatttg tccctgaggg agcgcatggt agagattggc    840

agacgctggc agcgcatccc gcagagccag aaggatcatt acaagagcca ggctgagttg    900

ctgcagaagg aatacaaagt ggaattggat ctctggctca agactttgtc acctgaagat    960

tatgctgcat acaaagaatc gacctatgct aagggtaaga atatggcgat gatgggaggc   1020

ccggccccca gcttgaaaca aacagatccg cagtcctcat cagcaaaggg tctgcaagaa   1080

gggtttgggg aggggcaggg gctccaggct gcaggaacag aggcatcaca gactatttgg   1140

gtaaactgtc aggtctctat ggaaccagaa gacaacagga agaaagatgg cgaagaggaa   1200

gaaagcagta actctttaga ctgcagcagt ggggaagaca tggaagttga tgtctga      1257


<210>  4394
<211>  418
<212>  PRT
<213>  Homosapiens

<400>  4394

Met Ile Arg Val Ile Gly Leu Arg Ser His Pro Lys Pro Arg Leu Ile 
1               5                   10                  15      


Ser Leu Gly Asp Tyr Gln Asp Ile Lys Val Ala Leu Pro Arg Ser Gln 
            20                  25                  30          


Gly His Trp Ser Asn Ala Asp Ile Leu Arg Leu Leu Glu Cys Met Glu 
        35                  40                  45              


Asn Asn Leu Pro Tyr Asp Asp Asn Gly Thr Phe Ser Ser Thr Gln Ser 
    50                  55                  60                  


His Met Asp Trp Gly Lys Val Ala Phe Lys Asn Phe Ser Gly Glu Met 
65                  70                  75                  80  


Cys Arg Leu Lys Trp Leu Glu Ile Ser Cys Ser Leu Arg Lys Phe Ser 
                85                  90                  95      


Thr Leu Lys Lys Leu Val Leu Glu Ala Lys Lys Cys Val Lys Asn Thr 
            100                 105                 110         


Asn Lys Ser Gln Lys Gly Arg Asn His Pro Asp Phe Pro Lys Arg Leu 
        115                 120                 125             


Leu Thr Ala Tyr Ile Arg Phe Phe Lys Glu Asn Trp Pro Gln Tyr Ser 
    130                 135                 140                 


Gln Met Tyr Pro Gly Met Arg Ser Gln Glu Val Thr Lys Ile Leu Ser 
145                 150                 155                 160 


Lys Lys Tyr Lys Glu Leu Pro Glu Gln Met Lys Gln Lys His Ile Gln 
                165                 170                 175     


Asp Phe Arg Lys Glu Lys Gln Glu Phe Glu Glu Lys Leu Ala Arg Phe 
            180                 185                 190         


Arg Glu Glu His Pro Asp Leu Asp Gln Lys Gly Lys Lys Ser Asp Ile 
        195                 200                 205             


Cys Lys Arg Val Gln Thr Lys Val Gln Lys Lys Val Gln Lys Asn Ile 
    210                 215                 220                 


Glu Glu Val Arg Ser Leu Pro Lys Thr Asp Gln Phe Phe Lys Lys Val 
225                 230                 235                 240 


Lys Phe His Gly Glu Pro Gln Lys Pro Pro Met Asn Gly Tyr Gln Lys 
                245                 250                 255     


Phe His Gln Asp Ser Trp Ser Ser Lys Glu Leu Gln His Leu Ser Leu 
            260                 265                 270         


Arg Glu Arg Met Val Glu Ile Gly Arg Arg Trp Gln Arg Ile Pro Gln 
        275                 280                 285             


Ser Gln Lys Asp His Tyr Lys Ser Gln Ala Glu Leu Leu Gln Lys Glu 
    290                 295                 300                 


Tyr Lys Val Glu Leu Asp Leu Trp Leu Lys Thr Leu Ser Pro Glu Asp 
305                 310                 315                 320 


Tyr Ala Ala Tyr Lys Glu Ser Thr Tyr Ala Lys Gly Lys Asn Met Ala 
                325                 330                 335     


Met Met Gly Gly Pro Ala Pro Ser Leu Lys Gln Thr Asp Pro Gln Ser 
            340                 345                 350         


Ser Ser Ala Lys Gly Leu Gln Glu Gly Phe Gly Glu Gly Gln Gly Leu 
        355                 360                 365             


Gln Ala Ala Gly Thr Glu Ala Ser Gln Thr Ile Trp Val Asn Cys Gln 
    370                 375                 380                 


Val Ser Met Glu Pro Glu Asp Asn Arg Lys Lys Asp Gly Glu Glu Glu 
385                 390                 395                 400 


Glu Ser Ser Asn Ser Leu Asp Cys Ser Ser Gly Glu Asp Met Glu Val 
                405                 410                 415     


Asp Val 
        


<210>  4395
<211>  1244
<212>  DNA
<213>  Homosapiens

<400>  4395
atgaagagaa gacagctcca gaactctgtt cagcaaactg aaaaaggtct ttttggttca     60

tcacgggtac aatatgttgt agatcatgca atgaaaattg ttttcctcaa tactgacccc    120

tctattgtaa cgacttatga tgctgttcaa aatgtgcatt ctgtgtggac tctccggaga    180

gtcaaatcag aggaagagaa tgttgtttta aagttctctg aacagggggg aaccccacag    240

aatgtggcca ctagcagctc cctcacagca catctcagaa gcctctccaa aggagattcc    300

cctgtgattt cacctttccg gaattactcc tccattcaca gccagagtcg ctcaacctca    360

tcacccagtc tacattctcg ctcaccttct atttccaaca tggcagctct aagtcgtgct    420

cattctcctg cgttaggagt gcactctttt tcaggggtgc aaaggttcaa catttcaagc    480

cataatcagt ctccaaagag acatagtatt tctcattctc caaatagtaa ttctaatgac    540

tcctttcttg caccagaaac ggagccaatt gttcctgaac tgtgtattga ccatttgtgg    600

acagaaatga ttactaatat aagagagaaa aattcacaag cctcaaaagt gtttattaca    660

tctgacctat gtgggcaaaa ttcctgtgct ttttagtaga gtcccagctc cacttacgct    720

gtgtaaagtt tcaagagagt aatgataaaa cccagctcat ctttgattca gtgaccaaca    780

taccagcaaa ggatgcagca ccagtggaga aaatagacac catgctggtc ttggaaggca    840

gtggaaacct ggtgctatac acaggagtgg ttcgggtaag caataagtag cacttcatgc    900

ctttagtagg acttcaggct gcctgcatga atattcgtaa tgttacttta gattgatatt    960

ttaaatttgt tatgttcctg tctgcacaat ttggcagaag aattttgtta ataattctca   1020

gtgaagcttc ccatttaggt gggtcctaat ttggagggct atggctcact gctattaaat   1080

gcattggtac tctaaacctg tcacagatgg gaaaccttca atgagtatag gtagattttt   1140

tttaaagtta aactagtttt gaaattgaag catgggtccc tttggtaagt actaaagttt   1200

tggtaaagtt tcactatatt aaatgtggta tatgttagct gtat                    1244


<210>  4396
<211>  231
<212>  PRT
<213>  Homosapiens

<400>  4396

Met Lys Arg Arg Gln Leu Gln Asn Ser Val Gln Gln Thr Glu Lys Gly 
1               5                   10                  15      


Leu Phe Gly Ser Ser Arg Val Gln Tyr Val Val Asp His Ala Met Lys 
            20                  25                  30          


Ile Val Phe Leu Asn Thr Asp Pro Ser Ile Val Thr Thr Tyr Asp Ala 
        35                  40                  45              


Val Gln Asn Val His Ser Val Trp Thr Leu Arg Arg Val Lys Ser Glu 
    50                  55                  60                  


Glu Glu Asn Val Val Leu Lys Phe Ser Glu Gln Gly Gly Thr Pro Gln 
65                  70                  75                  80  


Asn Val Ala Thr Ser Ser Ser Leu Thr Ala His Leu Arg Ser Leu Ser 
                85                  90                  95      


Lys Gly Asp Ser Pro Val Ile Ser Pro Phe Arg Asn Tyr Ser Ser Ile 
            100                 105                 110         


His Ser Gln Ser Arg Ser Thr Ser Ser Pro Ser Leu His Ser Arg Ser 
        115                 120                 125             


Pro Ser Ile Ser Asn Met Ala Ala Leu Ser Arg Ala His Ser Pro Ala 
    130                 135                 140                 


Leu Gly Val His Ser Phe Ser Gly Val Gln Arg Phe Asn Ile Ser Ser 
145                 150                 155                 160 


His Asn Gln Ser Pro Lys Arg His Ser Ile Ser His Ser Pro Asn Ser 
                165                 170                 175     


Asn Ser Asn Asp Ser Phe Leu Ala Pro Glu Thr Glu Pro Ile Val Pro 
            180                 185                 190         


Glu Leu Cys Ile Asp His Leu Trp Thr Glu Met Ile Thr Asn Ile Arg 
        195                 200                 205             


Glu Lys Asn Ser Gln Ala Ser Lys Val Phe Ile Thr Ser Asp Leu Cys 
    210                 215                 220                 


Gly Gln Asn Ser Cys Ala Phe 
225                 230     


<210>  4397
<211>  7170
<212>  DNA
<213>  Homosapiens

<400>  4397
tcttggaatt ggcgactgct gcggggctga gcgctggtct cacgcatctc gggagccagg     60

ttggtggcgc gatgagttgc agcaaggcct acggggagcg gtacgtcgcc tcggtgcagg    120

gctccgcccc gtcgcctcga aagaagtcaa cgagaggatt ctattttgca aagctgtatt    180

atgaagctaa agaatatgat cttgctaaaa aatacatatg tacttacatt aatgtgcgag    240

agatggatcc cagagctcac agatttctgg gtcttcttta tgaattggaa gaaaacacag    300

agaaagccgt tgaatgttac aggcgttcag tggaattaaa cccaacacaa aaagatcttg    360

tgttgaagat tgcagaattg ctttgtaaaa atgatgttac tgatggaaga gcagaatact    420

gggtggaaag agcagcaaaa cttttcccag gaagtcctgc aatttataaa ctaaaggaac    480

agcttctaga ttgtgaaggt gaagatggat ggaataaact ttttgacttg attcagtcag    540

aactttatgt aagacctgat gacgtccatg tgaacatccg gctagtggag ttgtatcgct    600

caactaaaag attgaaggat gctgtggccc gctgccatga ggcagagagg aacatagctt    660

tgcgttcaag tttagagtgg aattcgtgtg ttgtacagac ccttaaggaa tatctggagt    720

ctttacagtg tttggagtct gataaaagtg actggcgagc aaccaataca gacttactgc    780

tggcctatgc taatcttatg cttcttacgc tttccactag agatgtgcag gaaagtagag    840

aattactgga aagttttgat agtgctcttc agtctgcgaa atcttctttg ggtggaaatg    900

atgaactgtc agctactttc ttagaaatga aaggacattt ctacatgcat gctggttctc    960

tgctcttgaa gatgggtcag catggtaata atgttcaatg gcgagctctt tctgagctgg   1020

ctgcattgtg ctatctcata gcatttcagg ttccaagacc aaagattaaa ttaataaaag   1080

gtgaagctgg acaaaatctg ctggaaatga tggcctgtga ccgactgagc caatcagggc   1140

acatgttgct aaacttaagt cgtggcaagc aagatttttt aaaagtggtt gttgaaactt   1200

ttgccaacaa aagcgggcag tctgcattat atgatgctct gttttctagt cagtcaccta   1260

aggatacatc ttttcttggt agcgatgata ttggaaacat tgatgtacaa gaaccagagc   1320

ttgaagattt ggctagatac gatgttggtg ctattcgagc acataatggt agtcttcagc   1380

accttacttg gcttggctta cagtggaatt cattgcctgc tttacctgga atccgaaaat   1440

ggctaaaaca gcttttccat catttgcccc aggaaacctc aaggcttgaa acaaatgcac   1500

ctgaatcaat atgtatttta gatcttgaag tatttctcct tggagtagta tataccagcc   1560

acttacaatt aaaggagaaa tgtaattctc accacagctc ctatcagccg ttatgcctgc   1620

cccttcctgt gtgtaaacag ctttgtacag aaagacaaaa atcttggtgg gatgcggttt   1680

gtactctgat tcacagaaaa gcagtacctg gaaactcagc aaaattgaga cttctagttc   1740

agcatgaaat aaacactcta agagcccagg aaaaacatgg ccttcaacct gctctgcttg   1800

tacattgggc aaaatgcctt cagaaaatgg gcagcggtct taattctttt tatgatcaac   1860

gagaatacat agggagaagt gttcattatt ggaagaaagt tttgccattg ttgaagataa   1920

taaaaaagaa gaacagtatt cctgaaccta ttgatcctct gtttaaacat tttcatagtg   1980

tagacattca ggcatcagaa attgttgaat atgaagaaga cgcacacgta acttttgcta   2040

tattggatgc agtaaatgga aatatagaag atgctatgac tgcttttgaa tctataaaaa   2100

gtgttgtttc ttattggaat cttgcactga tttttcacag gaaggcagaa gacattgcaa   2160

atgatgccct ttctcctgaa gaacaagaag aatgcaaaaa ttatctgaga aagaccaggg   2220

gctacctaat aaagatttta gatgacagtg attcaaatct ttcagtggtc aagaaattgc   2280

ctgtgcccct ggagtctgta aaagagatgc ttaagtcagt catgcaggaa ctcgaaaact   2340

atagtgaagg aggtcctctc tataaaaatg gttctttgcg aaatgcggat tcagaaataa   2400

aacattctac accatctcct accaaatatt cactatcacc aagtaaaagt tacaagtatt   2460

ctcccaaaac accacctcga tgggcagaag atcagaattc tttactgaaa atgattcgcc   2520

aagaagtaaa ggccattaag gaagaaatgc aggagttgaa actaaatagc agtaagtcag   2580

catcccatca tcgttggccc acagagaatt atggaccaga ctcggtgcct gatggatatc   2640

aggggtcaca gacatttcat ggggctccac taacagttgc aactactggc ccttcagtat   2700

attatagtca gtcaccagca tataattccc agtatcttct cagaccagca gctaatgtta   2760

ctcccacaaa gggttcttct aatacagaat ttaagtcaac caaagaagga ttttccatcc   2820

ctgtgtctgc tgatggattt aaatttggca tttcggaacc aggaaatcaa gaaaagaaaa   2880

gtgaaaagcc tcttgaaaat gatactggct tacaggctca ggatattagt ggccggaaga   2940

agggccgtgg tgtgattttt ggccaaacaa gtagcacttt tacatttgca gatgttgcaa   3000

aatcaacttc aggagaagga tttcagtttg gcaaaaaaga cctcaatttc aagggatttt   3060

caggtgctgg agaaaaatta ttctcatcac aatacggtaa aatggccaat aaagcaaaca   3120

cttccggtga ctttgagaaa gatgatgatg cctataagac tgaggacagc gatgacatcc   3180

attttgaacc agtagttcaa atgcctgaaa aagtagaact tgtaacagga gaagaaggtg   3240

aaaaagttct gtattcacag ggggtaaaac tatttagatt tgatgctgag gtaagtcagt   3300

ggaaagaaag gggcttgggg aacttaaaaa ttctcaaaaa cgaggtcaat ggcaaagtaa   3360

gaatgctgat gcaaagagaa caagtactaa aagtgtgtgc taatcattgg ataacgacta   3420

caatgaacct gaagcccctc tctggatcag atagagcatg gatgtggtca gccagtgatt   3480

tctctgatgg tgatgccaaa ctagagcgat tggcagcaaa atttaaaaca ccagagctgg   3540

ctgaagaatt caagcagaaa tttgaggaat gccagcggct tctgttagac ataccacttc   3600

aaactcccca taaacttgta gatactggca gagctgccaa gttaatacag agagctgaag   3660

aaatgaagag tggactgaaa gatttcaaaa catttttgac aaatgatcaa acaaaagtcg   3720

ctgaggaaga aaataagggt tcaggtacag gtgcggccgg tgcctcagac acaacaataa   3780

aacccaatgc tgaaaacact gggcccacat tagaatggga taactatgat ttaagggaag   3840

atgctttgga tgatagtgtc agtagtagct cagtacatgc ttctccattg gcaagtagcc   3900

ctgtgagaaa aaatcttttc cactttgatg agtcaacaac aggatctaac ttcagtttta   3960

aatctgcttt gagtctatct aagtctcctg ccaagttgaa tcagagtggg acttcagttg   4020

gcactgatga agaatctgat gttactcaag aagaagagag agatggacag tactttgaac   4080

ctgttgttcc tttacctgat ctagttgaag tatccagtgg tgaggaaaat gaacaagttg   4140

tttttagtca cagggcagaa ttctacagat atgataaaga tgttggtcaa tggaaagaaa   4200

ggggcattgg tgatataaag attttacaga attatgataa taagcacgtt cgtatactga   4260

tgagaaggga ccaagtatta aaactttgtg ccaatcacag aataactcca gacatgagtt   4320

tgcaaaatat gaaagggaca gaaagagtat gggtgtggac tgcatgtgat tttgcagatg   4380

gagaaagaaa agtagagcat ttagctgttc gttttaaact acaggatgtt gcagactcgt   4440

ttaagaaaat ttttgatgaa gcaaaaacag cccaggaaaa agattctttg ataacacctc   4500

atgtttctcg gtcaagcact cccagagagt caccatgtgg caaaattgct gtagctgtat   4560

tagaagaaac cacaagagag aggacagatg ttattcaggg tgatgatgta gcagatgcag   4620

cttcagaagt tgaagtgtct agcacatctg aaacaacaac aaaagcagtg gtttctcctc   4680

caaagtttgt atttggttca gagtctgtta aaagaatttt tagtagtgaa aaatcaaaac   4740

catttgcatt tggcaacagt tctgccactg ggtctttgtt tggatttagt tttaatgcac   4800

ctttgaaaag taacaatagt gaaactagtt cagtagccca gagtggatct gaaagcaaag   4860

tggaacctaa aaaatgtgaa ctgtcaaaga actctgatat cgaacagtct tcagatagca   4920

aagtcaaaaa tctctctgct tcctttccaa cggaagaatc ttcaatcaac tacacattta   4980

aaacaccaga aaaggagcct ccattatggt atgctgaatt tactaaagaa gaattggttc   5040

agaagctcag ttccaccaca aaaagtgcag atcacttaaa cggcctgctt cgggaaatag   5100

aggcaaccaa tgcagtcctt atggagcaaa ttaagcttct caaaagtgaa ataagaagat   5160

tggaaaggaa tcaagagcaa gaggtgtctg cagctaacgt ggaacacttg aagaacgtct   5220

tgctgcagtt cattttcttg aagccaggta gtgaaagaga gagacttctt cctgttataa   5280

atacgatgtt gcagctcagc cttgaagaaa agggaaaact tgctgcggtt gctcaaggtg   5340

aggaataaaa tgcttcccgt tcttctggat gggcatccta tcttcgtagt tggtttggac   5400

ttcgataggt tgatggaagg aatgttttta ttaaccaaat aaaatctatt tacaaaaatg   5460

gttcatgtgt attaccatca ttcttttgtc aaaaagtgtg tatatgtttg catttacata   5520

tatttgtaca tctatatgac agatgtattt taaaagtttc aacttgaagt aaaagtacaa   5580

cagcttgaag tgttgatacc aggccacagc cctctaactc atgtgatctc ccatgcatgc   5640

tgccagaata aaaccaccag gaatgaattc actccccact tctctggaac ctcaggaccc   5700

gcccatttct cggcagtact gtgaattttg aagttaaact aaattttggt accataccaa   5760

ctggaattta ggctttaaaa ataatgtttc aaggccaggt gtggtgattc atgcctgaaa   5820

tcccactact tggggaggct gaggctggag aatcgtttga ggctagtgag ctgtgattgt   5880

atcactgcac tccagctcgg ggaacagagc gagaccttgt ctctaaaaat aataatagta   5940

ataaaaataa cattttatga ctatttattg caaggtcaga tttacagatt gttataaatt   6000

gttgagaaat ttttgtgatt agaatatgaa ggaaaaagct ttgttggtaa aagtgacatg   6060

ttaaggggct atgaagtaaa tatgctgcag ttaattgtgc taagttaaaa tacagtttag   6120

ttatttgctt taaaataaac tcttcttttt ttctttaaag tatactatct caaaactcat   6180

tatgttgtca gagccctaga gctggctagt gtaacactga ctatgaatag gtgggcccac   6240

cacttgagtt gaggtgattt catggtgtct ttccaggctc ttgatagggt gtcactgcat   6300

gcaagccatg aatctgtttt gagaatcctc tccattttcc caaataaaaa cctatcccaa   6360

cagtgactat atcactcagc attgaatcta aatataaaag tggtgctttc agtgtttttg   6420

gcagatagtg ttccataagc tttccatcag aagggatttt agacacctta gaggtccgtg   6480

ctacatcttc acagttcctc tgaataacct taggtggtag tgttacttgc ctttgacacc   6540

gctgcatatg ttttaatgac tagatccaaa ctgtgttgtt cttaaatcaa aaattggata   6600

atttttaata tttatgtatt aatcacatag tatgctctct gaagttctct taagccttca   6660

gtttatactc ttaattttct ttctgagctg gggaactgac tttgcacttt ggttacacag   6720

aacattggtt tccaatttag tttaactgaa atttgctgct gatatgttga gtttgttctt   6780

taaaaaatat ctcatatatc tcgtctttcc tccttagaag aacagaccta actagcgaat   6840

gtatgaatga aaatgcatct atttcagagc cgacatgaag agtttagttt ttttacttta   6900

taaactgtga atatgagtat gccagctgca tacgatgtaa ctaatcatat ttaaatatat   6960

ttcactttct ctttgacttg agaccttttg aagtctgtat aaacttgttt tgaaatatag   7020

tctccactta caaatgtcat aacaaaatac ttttttgcat gataaaaaat tgattacaaa   7080

aggcatattc tttcatggtt tctgcaatga gaggaagtgt aatgattatt ttaatatttc   7140

tattaaatat gtttaactgt atatttttat                                    7170


<210>  4398
<211>  1758
<212>  PRT
<213>  Homosapiens

<400>  4398

Met Ser Cys Ser Lys Ala Tyr Gly Glu Arg Tyr Val Ala Ser Val Gln 
1               5                   10                  15      


Gly Ser Ala Pro Ser Pro Arg Lys Lys Ser Thr Arg Gly Phe Tyr Phe 
            20                  25                  30          


Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 
        35                  40                  45              


Ile Cys Thr Tyr Ile Asn Val Arg Glu Met Asp Pro Arg Ala His Arg 
    50                  55                  60                  


Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Glu Lys Ala Val 
65                  70                  75                  80  


Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 
                85                  90                  95      


Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 
            100                 105                 110         


Arg Ala Glu Tyr Trp Val Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 
        115                 120                 125             


Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 
    130                 135                 140                 


Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 
145                 150                 155                 160 


Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Leu Tyr Arg 
                165                 170                 175     


Ser Thr Lys Arg Leu Lys Asp Ala Val Ala Arg Cys His Glu Ala Glu 
            180                 185                 190         


Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 
        195                 200                 205             


Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 
    210                 215                 220                 


Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 
225                 230                 235                 240 


Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg 
                245                 250                 255     


Glu Leu Leu Glu Ser Phe Asp Ser Ala Leu Gln Ser Ala Lys Ser Ser 
            260                 265                 270         


Leu Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly 
        275                 280                 285             


His Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His 
    290                 295                 300                 


Gly Asn Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys 
305                 310                 315                 320 


Tyr Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys 
                325                 330                 335     


Gly Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu 
            340                 345                 350         


Ser Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp 
        355                 360                 365             


Phe Leu Lys Val Val Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser 
    370                 375                 380                 


Ala Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser 
385                 390                 395                 400 


Phe Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Gln Glu Pro Glu 
                405                 410                 415     


Leu Glu Asp Leu Ala Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn 
            420                 425                 430         


Gly Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu 
        435                 440                 445             


Pro Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His 
    450                 455                 460                 


Leu Pro Gln Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile 
465                 470                 475                 480 


Cys Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser 
                485                 490                 495     


His Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln 
            500                 505                 510         


Pro Leu Cys Leu Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg 
        515                 520                 525             


Gln Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala 
    530                 535                 540                 


Val Pro Gly Asn Ser Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile 
545                 550                 555                 560 


Asn Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu 
                565                 570                 575     


Val His Trp Ala Lys Cys Leu Gln Lys Met Gly Ser Gly Leu Asn Ser 
            580                 585                 590         


Phe Tyr Asp Gln Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys 
        595                 600                 605             


Lys Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro 
    610                 615                 620                 


Glu Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln 
625                 630                 635                 640 


Ala Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Val Thr Phe Ala 
                645                 650                 655     


Ile Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Met Thr Ala Phe 
            660                 665                 670         


Glu Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe 
        675                 680                 685             


His Arg Lys Ala Glu Asp Ile Ala Asn Asp Ala Leu Ser Pro Glu Glu 
    690                 695                 700                 


Gln Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr Arg Gly Tyr Leu Ile 
705                 710                 715                 720 


Lys Ile Leu Asp Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu 
                725                 730                 735     


Pro Val Pro Leu Glu Ser Val Lys Glu Met Leu Lys Ser Val Met Gln 
            740                 745                 750         


Glu Leu Glu Asn Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser 
        755                 760                 765             


Leu Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr 
    770                 775                 780                 


Lys Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Lys Thr 
785                 790                 795                 800 


Pro Pro Arg Trp Ala Glu Asp Gln Asn Ser Leu Leu Lys Met Ile Arg 
                805                 810                 815     


Gln Glu Val Lys Ala Ile Lys Glu Glu Met Gln Glu Leu Lys Leu Asn 
            820                 825                 830         


Ser Ser Lys Ser Ala Ser His His Arg Trp Pro Thr Glu Asn Tyr Gly 
        835                 840                 845             


Pro Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly 
    850                 855                 860                 


Ala Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln 
865                 870                 875                 880 


Ser Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val 
                885                 890                 895     


Thr Pro Thr Lys Gly Ser Ser Asn Thr Glu Phe Lys Ser Thr Lys Glu 
            900                 905                 910         


Gly Phe Ser Ile Pro Val Ser Ala Asp Gly Phe Lys Phe Gly Ile Ser 
        915                 920                 925             


Glu Pro Gly Asn Gln Glu Lys Lys Ser Glu Lys Pro Leu Glu Asn Asp 
    930                 935                 940                 


Thr Gly Leu Gln Ala Gln Asp Ile Ser Gly Arg Lys Lys Gly Arg Gly 
945                 950                 955                 960 


Val Ile Phe Gly Gln Thr Ser Ser Thr Phe Thr Phe Ala Asp Val Ala 
                965                 970                 975     


Lys Ser Thr Ser Gly Glu Gly Phe Gln Phe Gly Lys Lys Asp Leu Asn 
            980                 985                 990         


Phe Lys Gly Phe Ser Gly Ala Gly  Glu Lys Leu Phe Ser  Ser Gln Tyr 
        995                 1000                 1005             


Gly Lys  Met Ala Asn Lys Ala  Asn Thr Ser Gly Asp  Phe Glu Lys 
    1010                 1015                 1020             


Asp Asp  Asp Ala Tyr Lys Thr  Glu Asp Ser Asp Asp  Ile His Phe 
    1025                 1030                 1035             


Glu Pro  Val Val Gln Met Pro  Glu Lys Val Glu Leu  Val Thr Gly 
    1040                 1045                 1050             


Glu Glu  Gly Glu Lys Val Leu  Tyr Ser Gln Gly Val  Lys Leu Phe 
    1055                 1060                 1065             


Arg Phe  Asp Ala Glu Val Ser  Gln Trp Lys Glu Arg  Gly Leu Gly 
    1070                 1075                 1080             


Asn Leu  Lys Ile Leu Lys Asn  Glu Val Asn Gly Lys  Val Arg Met 
    1085                 1090                 1095             


Leu Met  Gln Arg Glu Gln Val  Leu Lys Val Cys Ala  Asn His Trp 
    1100                 1105                 1110             


Ile Thr  Thr Thr Met Asn Leu  Lys Pro Leu Ser Gly  Ser Asp Arg 
    1115                 1120                 1125             


Ala Trp  Met Trp Ser Ala Ser  Asp Phe Ser Asp Gly  Asp Ala Lys 
    1130                 1135                 1140             


Leu Glu  Arg Leu Ala Ala Lys  Phe Lys Thr Pro Glu  Leu Ala Glu 
    1145                 1150                 1155             


Glu Phe  Lys Gln Lys Phe Glu  Glu Cys Gln Arg Leu  Leu Leu Asp 
    1160                 1165                 1170             


Ile Pro  Leu Gln Thr Pro His  Lys Leu Val Asp Thr  Gly Arg Ala 
    1175                 1180                 1185             


Ala Lys  Leu Ile Gln Arg Ala  Glu Glu Met Lys Ser  Gly Leu Lys 
    1190                 1195                 1200             


Asp Phe  Lys Thr Phe Leu Thr  Asn Asp Gln Thr Lys  Val Ala Glu 
    1205                 1210                 1215             


Glu Glu  Asn Lys Gly Ser Gly  Thr Gly Ala Ala Gly  Ala Ser Asp 
    1220                 1225                 1230             


Thr Thr  Ile Lys Pro Asn Ala  Glu Asn Thr Gly Pro  Thr Leu Glu 
    1235                 1240                 1245             


Trp Asp  Asn Tyr Asp Leu Arg  Glu Asp Ala Leu Asp  Asp Ser Val 
    1250                 1255                 1260             


Ser Ser  Ser Ser Val His Ala  Ser Pro Leu Ala Ser  Ser Pro Val 
    1265                 1270                 1275             


Arg Lys  Asn Leu Phe His Phe  Asp Glu Ser Thr Thr  Gly Ser Asn 
    1280                 1285                 1290             


Phe Ser  Phe Lys Ser Ala Leu  Ser Leu Ser Lys Ser  Pro Ala Lys 
    1295                 1300                 1305             


Leu Asn  Gln Ser Gly Thr Ser  Val Gly Thr Asp Glu  Glu Ser Asp 
    1310                 1315                 1320             


Val Thr  Gln Glu Glu Glu Arg  Asp Gly Gln Tyr Phe  Glu Pro Val 
    1325                 1330                 1335             


Val Pro  Leu Pro Asp Leu Val  Glu Val Ser Ser Gly  Glu Glu Asn 
    1340                 1345                 1350             


Glu Gln  Val Val Phe Ser His  Arg Ala Glu Phe Tyr  Arg Tyr Asp 
    1355                 1360                 1365             


Lys Asp  Val Gly Gln Trp Lys  Glu Arg Gly Ile Gly  Asp Ile Lys 
    1370                 1375                 1380             


Ile Leu  Gln Asn Tyr Asp Asn  Lys His Val Arg Ile  Leu Met Arg 
    1385                 1390                 1395             


Arg Asp  Gln Val Leu Lys Leu  Cys Ala Asn His Arg  Ile Thr Pro 
    1400                 1405                 1410             


Asp Met  Ser Leu Gln Asn Met  Lys Gly Thr Glu Arg  Val Trp Val 
    1415                 1420                 1425             


Trp Thr  Ala Cys Asp Phe Ala  Asp Gly Glu Arg Lys  Val Glu His 
    1430                 1435                 1440             


Leu Ala  Val Arg Phe Lys Leu  Gln Asp Val Ala Asp  Ser Phe Lys 
    1445                 1450                 1455             


Lys Ile  Phe Asp Glu Ala Lys  Thr Ala Gln Glu Lys  Asp Ser Leu 
    1460                 1465                 1470             


Ile Thr  Pro His Val Ser Arg  Ser Ser Thr Pro Arg  Glu Ser Pro 
    1475                 1480                 1485             


Cys Gly  Lys Ile Ala Val Ala  Val Leu Glu Glu Thr  Thr Arg Glu 
    1490                 1495                 1500             


Arg Thr  Asp Val Ile Gln Gly  Asp Asp Val Ala Asp  Ala Ala Ser 
    1505                 1510                 1515             


Glu Val  Glu Val Ser Ser Thr  Ser Glu Thr Thr Thr  Lys Ala Val 
    1520                 1525                 1530             


Val Ser  Pro Pro Lys Phe Val  Phe Gly Ser Glu Ser  Val Lys Arg 
    1535                 1540                 1545             


Ile Phe  Ser Ser Glu Lys Ser  Lys Pro Phe Ala Phe  Gly Asn Ser 
    1550                 1555                 1560             


Ser Ala  Thr Gly Ser Leu Phe  Gly Phe Ser Phe Asn  Ala Pro Leu 
    1565                 1570                 1575             


Lys Ser  Asn Asn Ser Glu Thr  Ser Ser Val Ala Gln  Ser Gly Ser 
    1580                 1585                 1590             


Glu Ser  Lys Val Glu Pro Lys  Lys Cys Glu Leu Ser  Lys Asn Ser 
    1595                 1600                 1605             


Asp Ile  Glu Gln Ser Ser Asp  Ser Lys Val Lys Asn  Leu Ser Ala 
    1610                 1615                 1620             


Ser Phe  Pro Thr Glu Glu Ser  Ser Ile Asn Tyr Thr  Phe Lys Thr 
    1625                 1630                 1635             


Pro Glu  Lys Glu Pro Pro Leu  Trp Tyr Ala Glu Phe  Thr Lys Glu 
    1640                 1645                 1650             


Glu Leu  Val Gln Lys Leu Ser  Ser Thr Thr Lys Ser  Ala Asp His 
    1655                 1660                 1665             


Leu Asn  Gly Leu Leu Arg Glu  Ile Glu Ala Thr Asn  Ala Val Leu 
    1670                 1675                 1680             


Met Glu  Gln Ile Lys Leu Leu  Lys Ser Glu Ile Arg  Arg Leu Glu 
    1685                 1690                 1695             


Arg Asn  Gln Glu Gln Glu Val  Ser Ala Ala Asn Val  Glu His Leu 
    1700                 1705                 1710             


Lys Asn  Val Leu Leu Gln Phe  Ile Phe Leu Lys Pro  Gly Ser Glu 
    1715                 1720                 1725             


Arg Glu  Arg Leu Leu Pro Val  Ile Asn Thr Met Leu  Gln Leu Ser 
    1730                 1735                 1740             


Leu Glu  Glu Lys Gly Lys Leu  Ala Ala Val Ala Gln  Gly Glu Glu 
    1745                 1750                 1755             


<210>  4399
<211>  1586
<212>  DNA
<213>  Homosapiens

<400>  4399
ggcgcgatga gttgcagcaa ggcctacggg gagcggtacg tcgcctcggt gcagggctcc     60

gccccgtcgc ctcgaaagaa gtcaacgaga ggattctatt ttgcaaagct gtattatgaa    120

gctaaagaat atgatcttgc taaaaaatac atatgtactt acattaatgt gcgagagatg    180

gatcccagag ctcacagatt tctgggtctt ctttatgaat tggaagaaaa cacagagaaa    240

gccgttgaat gttacaggcg ttcagtggaa ttaaacccaa cacaaaaaga tcttgtgttg    300

aagattgcag aattgctttg taaaaatgat gttactgatg gaagagcaga atactgggtg    360

gaaagagcag caaaactttt cccaggaagt cctgcaattt ataaactaaa ggaacagctt    420

ctagattgtg aaggtgaaga tggatggaat aaactttttg acttgattca gtcagaactt    480

tatgtaagac ctgatgacgt ccatgtgaac atccggctag tggagttgta tcgctcaact    540

aaaagattga aggatgctgt ggcccgctgc catgaggcag agaggaacat agctttgcgt    600

tcaagtttag agtggaattc gtgtgttgta cagaccctta aggaatatct ggagtcttta    660

cagtgtttgg agtctgataa aagtgactgg cgagcaacca atacagactt actgctggcc    720

tatgctaatc ttatgcttct tacgctttcc actagagatg tgcaggaaag tagagaatta    780

ctggaaagtt ttgatagtgc tcttcagtct gcgaaatctt ctttgggtgg aaatgatgaa    840

ctgtcagcta ctttcttaga aatgaaagga catttctaca tgcatgctgg ttctctgctc    900

ttgaagatgg gtcagcatgg taataatgtt caatggcgag ctctttctga gctggctgca    960

ttgtgctatc tcatagcatt tcaggttcca agaccaaaga ttaaattaat aaaaggtgaa   1020

gctggacaaa atctgctgga aatgatggcc tgtgaccgac tgagccaatc agggcacatg   1080

ttgctaaact taagtcgtgg caagcaagat tttttaaaag tggttgttga aacttttgcc   1140

aacaaaagcg ggcagtctgc attatatgat gctctgtttt ctagtcagtc acctaaggat   1200

acatcttttc ttggtagcga tgatattgga aacattgatg tacaagaacc agagcttgaa   1260

gatttggcta gatacgatgt tggtgctatt cgagcacata atggtagtct tcagcacctt   1320

acttggcttg gcttacagtg gaattcattg cctgctttac ctggaatccg aaaatggcta   1380

aaacagcttt tccatcattt gccccaggaa acctcaaggc ttgaaacaaa tgcacctgaa   1440

tcaatatgta ttttagatct tgaagtaagc aaagatttta acaaattaaa tattctgaat   1500

tttgtttaat ttttttttct aacttaactt ttccttaaat gaaacaggta tttctccttg   1560

gagtagtata taccagccac ttacaa                                        1586


<210>  4400
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  4400

Met Ser Cys Ser Lys Ala Tyr Gly Glu Arg Tyr Val Ala Ser Val Gln 
1               5                   10                  15      


Gly Ser Ala Pro Ser Pro Arg Lys Lys Ser Thr Arg Gly Phe Tyr Phe 
            20                  25                  30          


Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 
        35                  40                  45              


Ile Cys Thr Tyr Ile Asn Val Arg Glu Met Asp Pro Arg Ala His Arg 
    50                  55                  60                  


Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Glu Lys Ala Val 
65                  70                  75                  80  


Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 
                85                  90                  95      


Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 
            100                 105                 110         


Arg Ala Glu Tyr Trp Val Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 
        115                 120                 125             


Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 
    130                 135                 140                 


Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 
145                 150                 155                 160 


Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Leu Tyr Arg 
                165                 170                 175     


Ser Thr Lys Arg Leu Lys Asp Ala Val Ala Arg Cys His Glu Ala Glu 
            180                 185                 190         


Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 
        195                 200                 205             


Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 
    210                 215                 220                 


Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 
225                 230                 235                 240 


Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg 
                245                 250                 255     


Glu Leu Leu Glu Ser Phe Asp Ser Ala Leu Gln Ser Ala Lys Ser Ser 
            260                 265                 270         


Leu Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly 
        275                 280                 285             


His Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His 
    290                 295                 300                 


Gly Asn Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys 
305                 310                 315                 320 


Tyr Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys 
                325                 330                 335     


Gly Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu 
            340                 345                 350         


Ser Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp 
        355                 360                 365             


Phe Leu Lys Val Val Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser 
    370                 375                 380                 


Ala Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser 
385                 390                 395                 400 


Phe Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Gln Glu Pro Glu 
                405                 410                 415     


Leu Glu Asp Leu Ala Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn 
            420                 425                 430         


Gly Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu 
        435                 440                 445             


Pro Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His 
    450                 455                 460                 


Leu Pro Gln Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile 
465                 470                 475                 480 


Cys Ile Leu Asp Leu Glu Val Ser Lys Asp Phe Asn Lys Leu Asn Ile 
                485                 490                 495     


Leu Asn Phe Val 
            500 


<210>  4401
<211>  6899
<212>  DNA
<213>  Homosapiens

<400>  4401
aaagtaactt tatcgataga tttgatttaa ctcattatgt ccagaatatc attttaactt     60

ctaattaata taaaaattaa tgatatttta cattattgtt tttcaccaag tcttcaaaat    120

ccagtgtgtg tgtttacact tactgttagc atgtcttgat ttggactagc caccttgtga    180

ggttttaata gaatgtggct aggctaccat attggacacc atagctctca gaatgtttcc    240

ctgtcaccag ttgctataca tggcatgctt catgactggc ttactttatt aaactccttt    300

agccagaagt tcttctttac attagtagat cagaacaggt tgcatataga agttttttct    360

gtttctaatt ttttgccctt tgcattaatg gtggctgggg atgggttgtt ttcagccata    420

tgaatggtct tagattttat agtgttagct acccatagag taacagtttt tatttaattt    480

tatctagtat cattcttgaa cacaggcaaa ctagatgcaa ctctagtcac cttccattct    540

tggcaattgt taactttcct tacaggaact aatcacagtt ggctttggat tagtttcata    600

tgtatactaa tacttgctta tgttttaaga tttttttcag ttgctgcaaa tgcatggata    660

ttttggtaaa ctattgtatg ctaagtatag ttaggcaaca ctttaaaatt tttaaccttt    720

ttaaattcta gaaatttgta gtaattcttt tcaatgacta ttaagtaaac acaagatttt    780

tttgttttct ttggttttaa atagattctg tgttcactta gggtttttgg tagaacacta    840

aatcaggatg ctaattctaa ttcatgatta tcgtacatct ctgcatcaaa gtatatgtgt    900

tttttatcag tatgctgttt taacctatag ataggttcca tggtttttat tttcaggtag    960

agtattaacg tcaatactta ataccttatc tttgtcaatt tttttgactg gtgttacagc   1020

aaaagagaag aaaaaacctg aagattctcc ctcagatagt ctcggtctcc tgacctcgtg   1080

atccacccgc ctcggcctcc caaagtgctg ggattacagg catgagccac tgcgcctggc   1140

tgacacatgt cctaattctg gtattcacca gatttgtttc gtgttctccg ttgttagtca   1200

tcaaatttgt ctacttttta aatagaaaca ttagctagag caaggaactt agaaacactc   1260

aagcggcact gaatgtgtag aactgcataa ccaatatagc ttctttgctt tcacatttac   1320

aattagttgg agttttagtt cagccgtacc cagtatcttc cattctgctt ccaggaagaa   1380

atggaaaaat gtcagccatg atgatgcagt attttagtag caagttgatg gtgttttggt   1440

ttcccatggg aaatattgtc actggagcat tagcagctat cggtcactta ttagggtaaa   1500

aaagcaactt cagaagaatt taatatatgc caaagaatca acaaaggaag taatcagcca   1560

gggcaaaggt cgcacaagag attgtaatct agcaatcagc agtggaataa gcagtcagct   1620

taccagaaac ccaggaaaat gcttcagaaa ggtcagtcag gactaaggca atttaatgaa   1680

atgcaaaata aatgaaatct gaagtttaaa aatctagatt acaattctgg tttctaactc   1740

agttatgaga ccttgggcaa agtcattaaa tttctctgaa cttcagattt ttgggagtca   1800

ataaaccaat acatgtcaaa gggcctggta aactttacag tttagaccag gcgtggtgtc   1860

tcacccctgc aatctcagca ctttgggagg ccaaggcggg tggatcacat gaggccagga   1920

gtttgagacc agtctgaaca acatggtgaa atcccatctc tattaaaagt acaaaaatta   1980

tctgggcggg atggcatgca cctggaagtc ccagctactt gtggggctga ggtgggagga   2040

tggcttgagc ctgggaggca gaggttgctg tgagccaaga tcgtgccact gcactccaac   2100

ctgtgtgaca gagtgagacc ctgtctcaga aaaaataaca ctttacagtt tatcagcaaa   2160

cagcaaagtc ttgctaggca atgtaattga ttagttccgt gccctggatt ctgggctctt   2220

aactgtatga gcactgtagg tgtgagcagc aacaattacg aagctgcaga ggtaaaggta   2280

taagggcagt gattgaggat gtctaccaag cagatttcag caagtgtgtt tcaagaagta   2340

tgcagcaatc tgaaatacct aatcctgaaa aattgctaga atctagtctt ttaattttgg   2400

ccagtattta gcagtagttt ggccctctac tctaaattaa taaaaaataa gtagtactat   2460

attatgagct gtgttatcta acagtttgtc ttagctagta gcaattaatt tatagctgct   2520

attaaaatga ctaacgtagt taaaagtttg atgactaagt ttttttttgt ttgttttttt   2580

gttttgagct ggagtcttgc tctgtcacca ggctgaagtg cagtggcgtg atcttggctc   2640

actacaacct ccgcctcctg gcttccagca gttctctgcc tcagcctccc cagcagctgg   2700

gattacaggc acctgccact gtgcctggct aatttttgca tttttagtag agatagggtt   2760

tcaccatctt ggccaggctg gtcttgaact tgctgacctc gtgatccacc caccttagcc   2820

tcccaaactg ctaggattac agatttgagc caccacgccc ggccttgatg actaaatttt   2880

aagaaatgtt ttagcaattc ttcatacacc tttcacttat cttatagtta cttaattcct   2940

ctactcttat catttgatat tttcattttg tgtacctctg taaggccgaa tcaatagatt   3000

ttgaacaatc tcatacttaa cctttaaaaa aaatctaata ggcccagttt cctctcaaca   3060

atctttgaag aaccttcgag aaaggagaaa cacagacctc ccgcttctag acatgcacac   3120

tgtaacccgg gaagagggag aaggcatgga gacaactgat acggagtctg tgtcttccgc   3180

cagcacatac acacagtctt tagagcagct gcttaattct cccgaaacta aacttggtct   3240

gttactctgt ctaaatatgt tcttcttctt taatttcact gtcttattta attactatta   3300

ctctaaggta catatgcttt tttgggctgc tccaataaaa tttctttcaa tattccacta   3360

cctgtttgca ttagggttct ctagagggac agagctaatt ggatggttgg atggatggat   3420

gagatggatg gatggatgct tattaagtat taccttacac gatcactagg ccatctgcag   3480

actgaggagc aacgagagcc agtccaagtt ccaaaactga agaactagga gtctgatgtt   3540

caagggcagg aagcatccag cacaggagaa agatgtaggt tgggaggcta ggccagtctc   3600

gccttttcag gtttttctgc ctgctttata ttcactggca gctgattaga tggcacctac   3660

caggttaagg gtgggtctgc cttccccagc ccactgactc aaatgttaat ctcctttggc   3720

aacaccctca cagacaacac tcaggattaa tactttgcat cctttaatcc aatcaagttg   3780

acacccagta ttaaccatca cactgtccaa atggaaaaat tattaaacaa atctttttta   3840

aaataaaatg ctagctcttg ccctaggctt gaaccataaa taagtggtgg gaagtttata   3900

gtcacaaata ggtggtgggt attagaaagc aggataaact atcctctcac ccttccaaga   3960

aactgacagt ttcagtttat tcctcttgat gaagtaatgc taaatttttg tagtgatgtt   4020

ttggtatatt ttattacctg taattaatat tactgttcaa aatttagggg gaaatctgtc   4080

atcttcctga aacttcagaa tcacctggag taagggtcat ttgtattcat ggtcactgac   4140

cacgtggggt agaaactgca agtcatggtt ccttcaggca aagttaatag tggtgacatg   4200

gaggcatcat gatagagcag cagactccag aagccaattt gactttgtga tttctgcaaa   4260

aattacctgt caactgtgag cctgtttcat cgtctgtaaa gtttgaataa tgatacctac   4320

cccgcctgat agaagattct tatgagggaa catgatacgt gaccagtaaa tgttaatgct   4380

ttccttatac gtgaaatgac ataaaatctt ggaatattaa tagatgggaa gaagatgtgt   4440

aataaaactg tctataaaca caattctgac aaatttcaga actgggactc atagggcttg   4500

tattcagtta gatgacatgc tttacaacag agatactgtt ttatttgtgt cacctacaac   4560

atataatctg ttgattgagg tatgccgaat agatgaatgg caaagaaagc agagctataa   4620

aatatcacat agtaagatat ttatatttag atttttctta tttagaatct tcatctgtaa   4680

tgtatgattt tgaaaattaa ttcttggaac aacatgttgc agagcctcca ttatggtatg   4740

ctgaatttac taaagaagaa ttggttcaga agctcagttc caccacaaaa agtgcagatc   4800

acttaaacgg cctgcttcgg gaaatagagg caaccaatgc agtccttatg gagcaaatta   4860

agcttctcaa aagtgaaata agaagattgg aaaggaatca agagcaagag gtgtctgcag   4920

ctaacgtgga acacttgaag aacgtcttgc tgcagttcat tttcttgaag ccaggtagtg   4980

aaagagagag acttcttcct gttataaata cgatgttgca gctcagcctt gaagaaaagg   5040

gaaaacttgc tgcggttgct caaggtgagg aataaaatgc ttcccgttct tctggatggg   5100

catcctatct tcgtagttgg tttggacttc gataggttga tggaaggaat gtttttatta   5160

accaaataaa atctatttac aaaaatggtt catgtgtatt accatcattc ttttgtcaaa   5220

aagtgtgtat atgtttgcat ttacatatat ttgtacatct atatgacaga tgtattttaa   5280

aagtttcaac ttgaagtaaa agtacaacag cttgaagtgt tgataccagg ccacagccct   5340

ctaactcatg tgatctccca tgcatgctgc cagaataaaa ccaccaggaa tgaattcact   5400

ccccacttct ctggaacctc aggacccgcc catttctcgg cagtactgtg aattttgaag   5460

ttaaactaaa ttttggtacc ataccaactg gaatttaggc tttaaaaata atgtttcaag   5520

gccaggtgtg gtgattcatg cctgaaatcc cactacttgg ggaggctgag gctggagaat   5580

cgtttgaggc tagtgagctg tgattgtatc actgcactcc agctcgggga acagagcgag   5640

accttgtctc taaaaataat aatagtaata aaaataacat tttatgacta tttattgcaa   5700

ggtcagattt acagattgtt ataaattgtt gagaaatttt tgtgattaga atatgaagga   5760

aaaagctttg ttggtaaaag tgacatgtta aggggctatg aagtaaatat gctgcagtta   5820

attgtgctaa gttaaaatac agtttagtta tttgctttaa aataaactct tctttttttc   5880

tttaaagtat actatctcaa aactcattat gttgtcagag ccctagagct ggctagtgta   5940

acactgacta tgaataggtg ggcccaccac ttgagttgag gtgatttcat ggtgtctttc   6000

caggctcttg atagggtgtc actgcatgca agccatgaat ctgttttgag aatcctctcc   6060

attttcccaa ataaaaacct atcccaacag tgactatatc actcagcatt gaatctaaat   6120

ataaaagtgg tgctttcagt gtttttggca gatagtgttc cataagcttt ccatcagaag   6180

ggattttaga caccttagag gtccgtgcta catcttcaca gttcctctga ataaccttag   6240

gtggtagtgt tacttgcctt tgacaccgct gcatatgttt taatgactag atccaaactg   6300

tgttgttctt aaatcaaaaa ttggataatt tttaatattt atgtattaat cacatagtat   6360

gctctctgaa gttctcttaa gccttcagtt tatactctta attttctttc tgagctgggg   6420

aactgacttt gcactttggt tacacagaac attggtttcc aatttagttt aactgaaatt   6480

tgctgctgat atgttgagtt tgttctttaa aaaatatctc atatatctcg tctttcctcc   6540

ttagaagaac agacctaact agcgaatgta tgaatgaaaa tgcatctatt tcagagccga   6600

catgaagagt ttagtttttt tactttataa actgtgaata tgagtatgcc agctgcatac   6660

gatgtaacta atcatattta aatatatttc actttctctt tgacttgaga ccttttgaag   6720

tctgtataaa cttgttttga aatatagtct ccacttacaa atgtcataac aaaatacttt   6780

tttgcatgat aaaaaattga ttacaaaagg catattcttt catggtttct gcaatgagag   6840

gaagtgtaat gattatttta atatttctat taaatatgtt taactgtata tttttatgg    6899


<210>  4402
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  4402

Met Glu Gln Ile Lys Leu Leu Lys Ser Glu Ile Arg Arg Leu Glu Arg 
1               5                   10                  15      


Asn Gln Glu Gln Glu Val Ser Ala Ala Asn Val Glu His Leu Lys Asn 
            20                  25                  30          


Val Leu Leu Gln Phe Ile Phe Leu Lys Pro Gly Ser Glu Arg Glu Arg 
        35                  40                  45              


Leu Leu Pro Val Ile Asn Thr Met Leu Gln Leu Ser Leu Glu Glu Lys 
    50                  55                  60                  


Gly Lys Leu Ala Ala Val Ala Gln Gly Glu Glu 
65                  70                  75  


<210>  4403
<211>  6479
<212>  DNA
<213>  Homosapiens

<400>  4403
ggtgtgtgcc accacgcctg gctctttgtt tttttttttt atttttagta gagactgtgt     60

ttcaccatgt tggccaggct ggtctcgaac tcctgacctc aagtgatcag cccaccttgg    120

cctcccagac agagtgttgg gattacaggt gtgagccacc acgcctgtac ctggcctatc    180

tttcataggt tatacaaatt ccttggttcc cagtttttgc agtcttttcc aattcagttt    240

aattaatggt taactgttca ttcattatca aaaaaagtac agtgtaatag ataagaccat    300

gttactatta gaagtatggg tatcatcaaa ttaagatttt tgattctaaa attattaggt    360

tccaagacca aagattaaat taataaaagg tgaagctgga caaaatctgc tggaaatgat    420

ggcctgtgac cgactgagcc aatcagggca catgttgcta aacttaagtc gtggcaagca    480

agatttttta aaagtggttg ttgaaacttt tgccaacaaa agcgggcagt ctgcattata    540

tgatgctctg ttttctagtc agtcacctaa ggatacatct tttcttggta gcgatgatat    600

tggaaacatt gatgtacaag aaccagagct tgaagatttg gctagatacg atgttggtgc    660

tattcgagca cataatggta gtcttcagca ccttacttgg cttggcttac agtggaattc    720

attgcctgct ttacctggaa tccgaaaatg gctaaaacag cttttccatc atttgcccca    780

ggaaacctca aggcttgaaa caaatgcacc tgaatcaata tgtattttag atcttgaagt    840

atttctcctt ggagtagtat ataccagcca cttacaatta aaggagaaat gtaattctca    900

ccacagctcc tatcagccgt tatgcctgcc ccttcctgtg tgtaaacagc tttgtacaga    960

aagacaaaaa tcttggtggg atgcggtttg tactctgatt cacagaaaag cagtacctgg   1020

aaactcagca aaattgagac ttctagttca gcatgaaata aacactctaa gagcccagga   1080

aaaacatggc cttcaacctg ctctgcttgt acattgggca aaatgccttc agaaaatggg   1140

cagcggtctt aattcttttt atgatcaacg agaatacata gggagaagtg ttcattattg   1200

gaagaaagtt ttgccattgt tgaagataat aaaaaagaag aacagtattc ctgaacctat   1260

tgatcctctg tttaaacatt ttcatagtgt agacattcag gcatcagaaa ttgttgaata   1320

tgaagaagac gcacacgtaa cttttgctat attggatgca gtaaatggaa atatagaaga   1380

tgctatgact gcttttgaat ctataaaaag tgttgtttct tattggaatc ttgcactgat   1440

ttttcacagg aaggcagaag acattgcaaa tgatgccctt tctcctgaag aacaagaaga   1500

atgcaaaaat tatctgagaa agaccagggg ctacctaata aagattttag atgacagtga   1560

ttcaaatctt tcagtggtca agaaattgcc tgtgcccctg gagtctgtaa aagagatgct   1620

taagtcagtc atgcaggaac tcgaaaacta tagtgaagga ggtcctctct ataaaaatgg   1680

ttctttgcga aatgcggatt cagaaataaa acattctaca ccatctccta ccaaatattc   1740

actatcacca agtaaaagtt acaagtattc tcccaaaaca ccacctcgat gggcagaaga   1800

tcagaattct ttactgaaaa tgattcgcca agaagtaaag gccattaagg aagaaatgca   1860

ggagttgaaa ctaaatagca gtaagtcagc atcccatcat cgttggccca cagagaatta   1920

tggaccagac tcggtgcctg atggatatca ggggtcacag acatttcatg gggctccact   1980

aacagttgca actactggcc cttcagtata ttatagtcag tcaccagcat ataattccca   2040

gtatcttctc agaccagcag ctaatgttac tcccacaaag ggttcttcta atacagaatt   2100

taagtcaacc aaagaaggat tttccatccc tgtgtctgct gatggattta aatttggcat   2160

ttcggaacca ggaaatcaag aaaagaaaag tgaaaagcct cttgaaaatg atactggctt   2220

acaggctcag gatattagtg gccggaagaa gggccgtggt gtgatttttg gccaaacaag   2280

tagcactttt acatttgcag atgttgcaaa atcaacttca ggagaaggat ttcagtttgg   2340

caaaaaagac ctcaatttca agggattttc aggtgctgga gaaaaattat tctcatcaca   2400

atacggtaaa atggccaata aagcaaacac ttccggtgac tttgagaaag atgatgatgc   2460

ctataagact gaggacagcg atgacatcca ttttgaacca gtagttcaaa tgcctgaaaa   2520

agtagaactt gtaacaggag aagaaggtga aaaagttctg tattcacagg gggtaaaact   2580

atttagattt gatgctgagg taagtcagtg gaaagaaagg ggcttgggga acttaaaaat   2640

tctcaaaaac gaggtcaatg gcaaagtaag aatgctgatg caaagagaac aagtactaaa   2700

agtgtgtgct aatcattgga taacgactac aatgaacctg aagcccctct ctggatcaga   2760

tagagcatgg atgtggtcag ccagtgattt ctctgatggt gatgccaaac tagagcgatt   2820

ggcagcaaaa tttaaaacac cagagctggc tgaagaattc aagcagaaat ttgaggaatg   2880

ccagcggctt ctgttagaca taccacttca aactccccat aaacttgtag atactggcag   2940

agctgccaag ttaatacaga gagctgaaga aatgaagagt ggactgaaag atttcaaaac   3000

atttttgaca aatgatcaaa caaaagtcgc tgaggaagaa aataagggtt caggtacagg   3060

tgcggccggt gcctcagaca caacaataaa acccaatgct gaaaacactg ggcccacatt   3120

agaatgggat aactatgatt taagggaaga tgctttggat gatagtgtca gtagtagctc   3180

agtacatgct tctccattgg caagtagccc tgtgagaaaa aatcttttcc actttgatga   3240

gtcaacaaca ggatctaact tcagttttaa atctgctttg agtctatcta agtctcctgc   3300

caagttgaat cagagtggga cttcagttgg cactgatgaa gaatctgatg ttactcaaga   3360

agaagagaga gatggacagt actttgaacc tgttgttcct ttacctgatc tagttgaagt   3420

atccagtggt gaggaaaatg aacaagttgt ttttagtcac agggcagaat tctacagata   3480

tgataaagat gttggtcaat ggaaagaaag gggcattggt gatataaaga ttttacagaa   3540

ttatgataat aagcacgttc gtatactgat gagaagggac caagtattaa aactttgtgc   3600

caatcacaga ataactccag acatgagttt gcaaaatatg aaagggacag aaagagtatg   3660

ggtgtggact gcatgtgatt ttgcagatgg agaaagaaaa gtagagcatt tagctgttcg   3720

ttttaaacta caggatgttg cagactcgtt taagaaaatt tttgatgaag caaaaacagc   3780

ccaggaaaaa gattctttga taacacctca tgtttctcgg tcaagcactc ccagagagtc   3840

accatgtggc aaaattgctg tagctgtatt agaagaaacc acaagagaga ggacagatgt   3900

tattcagggt gatgatgtag cagatgcagc ttcagaagtt gaagtgtcta gcacatctga   3960

aacaacaaca aaagcagtgg tttctcctcc aaagtttgta tttggttcag agtctgttaa   4020

aagaattttt agtagtgaaa aatcaaaacc atttgcattt ggcaacagtt ctgccactgg   4080

gtctttgttt ggatttagtt ttaatgcacc tttgaaaagt aacaatagtg aaactagttc   4140

agtagcccag agtggatctg aaagcaaagt ggaacctaaa aaatgtgaac tgtcaaagaa   4200

ctctgatatc gaacagtctt cagatagcaa agtcaaaaat ctctctgctt cctttccaac   4260

ggaagaatct tcaatcaact acacatttaa aacaccagaa aaggagcctc cattatggta   4320

tgctgaattt actaaagaag aattggttca gaagctcagt tccaccacaa aaagtgcaga   4380

tcacttaaac ggcctgcttc gggaaataga ggcaaccaat gcagtcctta tggagcaaat   4440

taagcttctc aaaagtgaaa taagaagatt ggaaaggaat caagagcaag aggtgtctgc   4500

agctaacgtg gaacacttga agaacgtctt gctgcagttc attttcttga agccaggtag   4560

tgaaagagag agacttcttc ctgttataaa tacgatgttg cagctcagcc ttgaagaaaa   4620

gggaaaactt gctgcggttg ctcaaggtga ggaataaaat gcttcccgtt cttctggatg   4680

ggcatcctat cttcgtagtt ggtttggact tcgataggtt gatggaagga atgtttttat   4740

taaccaaata aaatctattt acaaaaatgg ttcatgtgta ttaccatcat tcttttgtca   4800

aaaagtgtgt atatgtttgc atttacatat atttgtacat ctatatgaca gatgtatttt   4860

aaaagtttca acttgaagta aaagtacaac agcttgaagt gttgatacca ggccacagcc   4920

ctctaactca tgtgatctcc catgcatgct gccagaataa aaccaccagg aatgaattca   4980

ctccccactt ctctggaacc tcaggacccg cccatttctc ggcagtactg tgaattttga   5040

agttaaacta aattttggta ccataccaac tggaatttag gctttaaaaa taatgtttca   5100

aggccaggtg tggtgattca tgcctgaaat cccactactt ggggaggctg aggctggaga   5160

atcgtttgag gctagtgagc tgtgattgta tcactgcact ccagctcggg gaacagagcg   5220

agaccttgtc tctaaaaata ataatagtaa taaaaataac attttatgac tatttattgc   5280

aaggtcagat ttacagattg ttataaattg ttgagaaatt tttgtgatta gaatatgaag   5340

gaaaaagctt tgttggtaaa agtgacatgt taaggggcta tgaagtaaat atgctgcagt   5400

taattgtgct aagttaaaat acagtttagt tatttgcttt aaaataaact cttctttttt   5460

tctttaaagt atactatctc aaaactcatt atgttgtcag agccctagag ctggctagtg   5520

taacactgac tatgaatagg tgggcccacc acttgagttg aggtgatttc atggtgtctt   5580

tccaggctct tgatagggtg tcactgcatg caagccatga atctgttttg agaatcctct   5640

ccattttccc aaataaaaac ctatcccaac agtgactata tcactcagca ttgaatctaa   5700

atataaaagt ggtgctttca gtgtttttgg cagatagtgt tccataagct ttccatcaga   5760

agggatttta gacaccttag aggtccgtgc tacatcttca cagttcctct gaataacctt   5820

aggtggtagt gttacttgcc tttgacaccg ctgcatatgt tttaatgact agatccaaac   5880

tgtgttgttc ttaaatcaaa aattggataa tttttaatat ttatgtatta atcacatagt   5940

atgctctctg aagttctctt aagccttcag tttatactct taattttctt tctgagctgg   6000

ggaactgact ttgcactttg gttacacaga acattggttt ccaatttagt ttaactgaaa   6060

tttgctgctg atatgttgag tttgttcttt aaaaaatatc tcatatatct cgtctttcct   6120

ccttagaaga acagacctaa ctagcgaatg tatgaatgaa aatgcatcta tttcagagcc   6180

gacatgaaga gtttagtttt tttactttat aaactgtgaa tatgagtatg ccagctgcat   6240

acgatgtaac taatcatatt taaatatatt tcactttctc tttgacttga gaccttttga   6300

agtctgtata aacttgtttt gaaatatagt ctccacttac aaatgtcata acaaaatact   6360

tttttgcatg ataaaaaatt gattacaaaa ggcatattct ttcatggttt ctgcaatgag   6420

aggaagtgta atgattattt taatatttct attaaatatg tttaactgta tatttttat    6479


<210>  4404
<211>  1412
<212>  PRT
<213>  Homosapiens

<400>  4404

Met Ala Cys Asp Arg Leu Ser Gln Ser Gly His Met Leu Leu Asn Leu 
1               5                   10                  15      


Ser Arg Gly Lys Gln Asp Phe Leu Lys Val Val Val Glu Thr Phe Ala 
            20                  25                  30          


Asn Lys Ser Gly Gln Ser Ala Leu Tyr Asp Ala Leu Phe Ser Ser Gln 
        35                  40                  45              


Ser Pro Lys Asp Thr Ser Phe Leu Gly Ser Asp Asp Ile Gly Asn Ile 
    50                  55                  60                  


Asp Val Gln Glu Pro Glu Leu Glu Asp Leu Ala Arg Tyr Asp Val Gly 
65                  70                  75                  80  


Ala Ile Arg Ala His Asn Gly Ser Leu Gln His Leu Thr Trp Leu Gly 
                85                  90                  95      


Leu Gln Trp Asn Ser Leu Pro Ala Leu Pro Gly Ile Arg Lys Trp Leu 
            100                 105                 110         


Lys Gln Leu Phe His His Leu Pro Gln Glu Thr Ser Arg Leu Glu Thr 
        115                 120                 125             


Asn Ala Pro Glu Ser Ile Cys Ile Leu Asp Leu Glu Val Phe Leu Leu 
    130                 135                 140                 


Gly Val Val Tyr Thr Ser His Leu Gln Leu Lys Glu Lys Cys Asn Ser 
145                 150                 155                 160 


His His Ser Ser Tyr Gln Pro Leu Cys Leu Pro Leu Pro Val Cys Lys 
                165                 170                 175     


Gln Leu Cys Thr Glu Arg Gln Lys Ser Trp Trp Asp Ala Val Cys Thr 
            180                 185                 190         


Leu Ile His Arg Lys Ala Val Pro Gly Asn Ser Ala Lys Leu Arg Leu 
        195                 200                 205             


Leu Val Gln His Glu Ile Asn Thr Leu Arg Ala Gln Glu Lys His Gly 
    210                 215                 220                 


Leu Gln Pro Ala Leu Leu Val His Trp Ala Lys Cys Leu Gln Lys Met 
225                 230                 235                 240 


Gly Ser Gly Leu Asn Ser Phe Tyr Asp Gln Arg Glu Tyr Ile Gly Arg 
                245                 250                 255     


Ser Val His Tyr Trp Lys Lys Val Leu Pro Leu Leu Lys Ile Ile Lys 
            260                 265                 270         


Lys Lys Asn Ser Ile Pro Glu Pro Ile Asp Pro Leu Phe Lys His Phe 
        275                 280                 285             


His Ser Val Asp Ile Gln Ala Ser Glu Ile Val Glu Tyr Glu Glu Asp 
    290                 295                 300                 


Ala His Val Thr Phe Ala Ile Leu Asp Ala Val Asn Gly Asn Ile Glu 
305                 310                 315                 320 


Asp Ala Met Thr Ala Phe Glu Ser Ile Lys Ser Val Val Ser Tyr Trp 
                325                 330                 335     


Asn Leu Ala Leu Ile Phe His Arg Lys Ala Glu Asp Ile Ala Asn Asp 
            340                 345                 350         


Ala Leu Ser Pro Glu Glu Gln Glu Glu Cys Lys Asn Tyr Leu Arg Lys 
        355                 360                 365             


Thr Arg Gly Tyr Leu Ile Lys Ile Leu Asp Asp Ser Asp Ser Asn Leu 
    370                 375                 380                 


Ser Val Val Lys Lys Leu Pro Val Pro Leu Glu Ser Val Lys Glu Met 
385                 390                 395                 400 


Leu Lys Ser Val Met Gln Glu Leu Glu Asn Tyr Ser Glu Gly Gly Pro 
                405                 410                 415     


Leu Tyr Lys Asn Gly Ser Leu Arg Asn Ala Asp Ser Glu Ile Lys His 
            420                 425                 430         


Ser Thr Pro Ser Pro Thr Lys Tyr Ser Leu Ser Pro Ser Lys Ser Tyr 
        435                 440                 445             


Lys Tyr Ser Pro Lys Thr Pro Pro Arg Trp Ala Glu Asp Gln Asn Ser 
    450                 455                 460                 


Leu Leu Lys Met Ile Arg Gln Glu Val Lys Ala Ile Lys Glu Glu Met 
465                 470                 475                 480 


Gln Glu Leu Lys Leu Asn Ser Ser Lys Ser Ala Ser His His Arg Trp 
                485                 490                 495     


Pro Thr Glu Asn Tyr Gly Pro Asp Ser Val Pro Asp Gly Tyr Gln Gly 
            500                 505                 510         


Ser Gln Thr Phe His Gly Ala Pro Leu Thr Val Ala Thr Thr Gly Pro 
        515                 520                 525             


Ser Val Tyr Tyr Ser Gln Ser Pro Ala Tyr Asn Ser Gln Tyr Leu Leu 
    530                 535                 540                 


Arg Pro Ala Ala Asn Val Thr Pro Thr Lys Gly Ser Ser Asn Thr Glu 
545                 550                 555                 560 


Phe Lys Ser Thr Lys Glu Gly Phe Ser Ile Pro Val Ser Ala Asp Gly 
                565                 570                 575     


Phe Lys Phe Gly Ile Ser Glu Pro Gly Asn Gln Glu Lys Lys Ser Glu 
            580                 585                 590         


Lys Pro Leu Glu Asn Asp Thr Gly Leu Gln Ala Gln Asp Ile Ser Gly 
        595                 600                 605             


Arg Lys Lys Gly Arg Gly Val Ile Phe Gly Gln Thr Ser Ser Thr Phe 
    610                 615                 620                 


Thr Phe Ala Asp Val Ala Lys Ser Thr Ser Gly Glu Gly Phe Gln Phe 
625                 630                 635                 640 


Gly Lys Lys Asp Leu Asn Phe Lys Gly Phe Ser Gly Ala Gly Glu Lys 
                645                 650                 655     


Leu Phe Ser Ser Gln Tyr Gly Lys Met Ala Asn Lys Ala Asn Thr Ser 
            660                 665                 670         


Gly Asp Phe Glu Lys Asp Asp Asp Ala Tyr Lys Thr Glu Asp Ser Asp 
        675                 680                 685             


Asp Ile His Phe Glu Pro Val Val Gln Met Pro Glu Lys Val Glu Leu 
    690                 695                 700                 


Val Thr Gly Glu Glu Gly Glu Lys Val Leu Tyr Ser Gln Gly Val Lys 
705                 710                 715                 720 


Leu Phe Arg Phe Asp Ala Glu Val Ser Gln Trp Lys Glu Arg Gly Leu 
                725                 730                 735     


Gly Asn Leu Lys Ile Leu Lys Asn Glu Val Asn Gly Lys Val Arg Met 
            740                 745                 750         


Leu Met Gln Arg Glu Gln Val Leu Lys Val Cys Ala Asn His Trp Ile 
        755                 760                 765             


Thr Thr Thr Met Asn Leu Lys Pro Leu Ser Gly Ser Asp Arg Ala Trp 
    770                 775                 780                 


Met Trp Ser Ala Ser Asp Phe Ser Asp Gly Asp Ala Lys Leu Glu Arg 
785                 790                 795                 800 


Leu Ala Ala Lys Phe Lys Thr Pro Glu Leu Ala Glu Glu Phe Lys Gln 
                805                 810                 815     


Lys Phe Glu Glu Cys Gln Arg Leu Leu Leu Asp Ile Pro Leu Gln Thr 
            820                 825                 830         


Pro His Lys Leu Val Asp Thr Gly Arg Ala Ala Lys Leu Ile Gln Arg 
        835                 840                 845             


Ala Glu Glu Met Lys Ser Gly Leu Lys Asp Phe Lys Thr Phe Leu Thr 
    850                 855                 860                 


Asn Asp Gln Thr Lys Val Ala Glu Glu Glu Asn Lys Gly Ser Gly Thr 
865                 870                 875                 880 


Gly Ala Ala Gly Ala Ser Asp Thr Thr Ile Lys Pro Asn Ala Glu Asn 
                885                 890                 895     


Thr Gly Pro Thr Leu Glu Trp Asp Asn Tyr Asp Leu Arg Glu Asp Ala 
            900                 905                 910         


Leu Asp Asp Ser Val Ser Ser Ser Ser Val His Ala Ser Pro Leu Ala 
        915                 920                 925             


Ser Ser Pro Val Arg Lys Asn Leu Phe His Phe Asp Glu Ser Thr Thr 
    930                 935                 940                 


Gly Ser Asn Phe Ser Phe Lys Ser Ala Leu Ser Leu Ser Lys Ser Pro 
945                 950                 955                 960 


Ala Lys Leu Asn Gln Ser Gly Thr Ser Val Gly Thr Asp Glu Glu Ser 
                965                 970                 975     


Asp Val Thr Gln Glu Glu Glu Arg Asp Gly Gln Tyr Phe Glu Pro Val 
            980                 985                 990         


Val Pro Leu Pro Asp Leu Val Glu  Val Ser Ser Gly Glu  Glu Asn Glu 
        995                 1000                 1005             


Gln Val  Val Phe Ser His Arg  Ala Glu Phe Tyr Arg  Tyr Asp Lys 
    1010                 1015                 1020             


Asp Val  Gly Gln Trp Lys Glu  Arg Gly Ile Gly Asp  Ile Lys Ile 
    1025                 1030                 1035             


Leu Gln  Asn Tyr Asp Asn Lys  His Val Arg Ile Leu  Met Arg Arg 
    1040                 1045                 1050             


Asp Gln  Val Leu Lys Leu Cys  Ala Asn His Arg Ile  Thr Pro Asp 
    1055                 1060                 1065             


Met Ser  Leu Gln Asn Met Lys  Gly Thr Glu Arg Val  Trp Val Trp 
    1070                 1075                 1080             


Thr Ala  Cys Asp Phe Ala Asp  Gly Glu Arg Lys Val  Glu His Leu 
    1085                 1090                 1095             


Ala Val  Arg Phe Lys Leu Gln  Asp Val Ala Asp Ser  Phe Lys Lys 
    1100                 1105                 1110             


Ile Phe  Asp Glu Ala Lys Thr  Ala Gln Glu Lys Asp  Ser Leu Ile 
    1115                 1120                 1125             


Thr Pro  His Val Ser Arg Ser  Ser Thr Pro Arg Glu  Ser Pro Cys 
    1130                 1135                 1140             


Gly Lys  Ile Ala Val Ala Val  Leu Glu Glu Thr Thr  Arg Glu Arg 
    1145                 1150                 1155             


Thr Asp  Val Ile Gln Gly Asp  Asp Val Ala Asp Ala  Ala Ser Glu 
    1160                 1165                 1170             


Val Glu  Val Ser Ser Thr Ser  Glu Thr Thr Thr Lys  Ala Val Val 
    1175                 1180                 1185             


Ser Pro  Pro Lys Phe Val Phe  Gly Ser Glu Ser Val  Lys Arg Ile 
    1190                 1195                 1200             


Phe Ser  Ser Glu Lys Ser Lys  Pro Phe Ala Phe Gly  Asn Ser Ser 
    1205                 1210                 1215             


Ala Thr  Gly Ser Leu Phe Gly  Phe Ser Phe Asn Ala  Pro Leu Lys 
    1220                 1225                 1230             


Ser Asn  Asn Ser Glu Thr Ser  Ser Val Ala Gln Ser  Gly Ser Glu 
    1235                 1240                 1245             


Ser Lys  Val Glu Pro Lys Lys  Cys Glu Leu Ser Lys  Asn Ser Asp 
    1250                 1255                 1260             


Ile Glu  Gln Ser Ser Asp Ser  Lys Val Lys Asn Leu  Ser Ala Ser 
    1265                 1270                 1275             


Phe Pro  Thr Glu Glu Ser Ser  Ile Asn Tyr Thr Phe  Lys Thr Pro 
    1280                 1285                 1290             


Glu Lys  Glu Pro Pro Leu Trp  Tyr Ala Glu Phe Thr  Lys Glu Glu 
    1295                 1300                 1305             


Leu Val  Gln Lys Leu Ser Ser  Thr Thr Lys Ser Ala  Asp His Leu 
    1310                 1315                 1320             


Asn Gly  Leu Leu Arg Glu Ile  Glu Ala Thr Asn Ala  Val Leu Met 
    1325                 1330                 1335             


Glu Gln  Ile Lys Leu Leu Lys  Ser Glu Ile Arg Arg  Leu Glu Arg 
    1340                 1345                 1350             


Asn Gln  Glu Gln Glu Val Ser  Ala Ala Asn Val Glu  His Leu Lys 
    1355                 1360                 1365             


Asn Val  Leu Leu Gln Phe Ile  Phe Leu Lys Pro Gly  Ser Glu Arg 
    1370                 1375                 1380             


Glu Arg  Leu Leu Pro Val Ile  Asn Thr Met Leu Gln  Leu Ser Leu 
    1385                 1390                 1395             


Glu Glu  Lys Gly Lys Leu Ala  Ala Val Ala Gln Gly  Glu Glu 
    1400                 1405                 1410         


<210>  4405
<211>  8074
<212>  DNA
<213>  Homosapiens

<400>  4405
ccatagtgtt gagactacag gtgtgtgtta ctgctcccag ctgggaggca ggcttttaaa     60

ggcatccaaa ggaagatgga aatgctgata catatgtact tacattaatg tgcgagagat    120

ggatcccaga gctcacagat ttctgggtct tctttatgaa ttggaagaaa acacagagaa    180

agccgttgaa tgttacaggc gttcagtgga attaaaccca acacaaaaag atcttgtgtt    240

gaagattgca gaattgcttt gtaaaaatga tgttactgat ggaagagcag aatactgggt    300

ggaaagagca gcaaaacttt tcccaggaag tcctgcaatt tataaactaa aggaacagct    360

tctagattgt gaaggtgaag atggatggaa taaacttttt gacttgattc agtcagaact    420

ttatgtaaga cctgatgacg tccatgtgaa catccggcta gtggagttgt atcgctcaac    480

taaaagattg aaggatgctg tggcccgctg ccatgaggca gagaggaaca tagctttgcg    540

ttcaagttta gagtggaatt cgtgtgttgt acagaccctt aagttttgat agtgctcttc    600

agtctgcgaa atcttctttg ggtggaaatg atgaactgtc agctactttc ttagaaatga    660

aaggacattt ctacatgcat gctggttctc tgctcttgaa gatgggtcag catggtaata    720

atgttcaatg gcgagctctt tctgagctgg ctgcattgtg ctatctcata gcatttcagg    780

ttccaagacc aaagattaaa ttaataaaag gtgaagctgg acaaaatctg ctggaaatga    840

tggcctgtga ccgactgagc caatcagggc acatgttgct aaacttaagt cgtggcaagc    900

aagatttttt aaaagtggtt gttgaaactt ttgccaacaa aagcgggcag tctgcattat    960

atgatgctct gttttctagt cagtcaccta aggatacatc ttttcttggt agcgatgata   1020

ttggaaacat tgatgtacaa gaaccagagc ttgaagattt ggctagatac gatgttggtg   1080

ctattcgagc acataatggt agtcttcagc accttacttg gcttggctta cagtggaatt   1140

cattgcctgc tttacctgga atccgaaaat ggctaaaaca gcttttccat catttgcccc   1200

aggaaacctc aaggcttgaa acaaatgcac ctgaatcaat atgtatttta gatcttgaag   1260

tatttctcct tggagtagta tataccagcc acttacaatt aaaggagaaa tgtaattctc   1320

accacagctc ctatcagccg ttatgcctgc cccttcctgt gtgtaaacag ctttgtacag   1380

aaagacaaaa atcttggtgg gatgcggttt gtactctgat tcacagaaaa gcagtgtaag   1440

tagtaaaaca aaaatattgc tttcacttag tgcgtaggtt ttaccgggga tttaatcctc   1500

gtgtgaagat ttaatttgtc atgtgaccca ttaacatata tgtatgtaag cgctgaactg   1560

tgtatttaga aagcaatttt agtaaattga actatttttt agacctggaa actcagcaaa   1620

attgagactt ctagttcagc atgaaataaa cactctaaga gcccaggaaa aacatggcct   1680

tcaacctgct ctgcttgtac attgggcaaa atgccttcag aaaatggtga gttttaaagt   1740

ataagcattt taaaagaaca ttaccttaat tttttaaaat catgaacttt ttattgaaag   1800

tttttttgtt ctgaaaacag cagctttgtc atattatgac agatgtgttt tttattgctg   1860

caaaatagtt aatgtagtta aatataagca cttagaggag caatgcctgg cacacagtga   1920

atgttacata ttagctgagc tgttactgtt attccttaat aattaagttc tgataattat   1980

tcagcctgaa aattaaaaaa aaattagcac aaggctttgt aggtaagacc attatagatc   2040

tttctaaata tttaaggtgt gttttgtgtc accattaggt gtagatggtc agccttttga   2100

acaaactgac actacagaag aggcaggttt cagctatcta aaaatggcaa ctgttaaaaa   2160

gcagttggga ttgctacgtt agggtggtat cattagaagc atttaaaagt tgagtgtaga   2220

ggccgggtgc ggtggctcac acctgtaatc ccagcacgtt aggaggccga ggcgggcaga   2280

tcacaaggtc aggagatcga gatcattcct ggctaacacg gtgaaacccc gtctctacta   2340

aaaatacaaa aaaaactcta ctaaaactac aaaattagcc agacatggtg gcaggtgcct   2400

gtaatcccag ctacttggga agctgaggca ggagaattgc ttgaacctgc acggcagagg   2460

ttgcagtgag ttcactggta ttaaggtggt ttagttatta cagtatttgg aagttgaaca   2520

aatgactatt gaggtaccat ttggttttga cttgaaattt tagccagttc ttacaacttg   2580

taaatgaact ttagatctaa tcatgcgtgt tccttaaagt tgtgtgcttt taactttctt   2640

ttttagggca gcggtcttaa ttctttttat gatcaacgag aatacatagg gagaagtgtt   2700

cattattgga agaaagtttt gccattgttg aagataataa aaaagaagaa cagtattcct   2760

gaacctattg atcctctgtt taaacatttt catagtgtag acattcaggc atcagaaatt   2820

gttgaatatg aagaagacgc acacgtaact tttgctatat tggatgcagt aaatggaaat   2880

atagaagatg ctatgactgc ttttgaatct ataaaaagtg ttgtttctta ttggaatctt   2940

gcactgattt ttcacaggaa ggcagaagac attgcaaatg atgccctttc tcctgaagaa   3000

caagaagaat gcaaaaatta tctgagaaag accaggggct acctaataaa gattttagat   3060

gacagtgatt caaatctttc agtggtcaag aaattgcctg tgcccctgga gtctgtaaaa   3120

gagatgctta agtcagtcat gcaggaactc gaaaactata gtgaaggagg tcctctctat   3180

aaaaatggtt ctttgcgaaa tgcggattca gaaataaaac attctacacc atctcctacc   3240

aaatattcac tatcaccaag taaaagttac aaggtaaaca ggaaagaatg gaatcatttc   3300

attgtgaaat tgtttctaag tgttttaaat gctcttttgt tatttttatt ttttttttag   3360

tattctccca aaacaccacc tcgatgggca gaagatcaga attctttact gaaaatgatt   3420

cgccaagaag taaaggccat taaggaagaa atgcaggagt tgaaactaaa tagcagtaag   3480

tcagcatccc atcatcgttg gcccacagag aattatggac cagactcggt gcctgatgga   3540

tatcaggggt cacagacatt tcatggggct ccactaacag ttgcaactac tggcccttca   3600

gtatattata gtcagtcacc agcatataat tcccagtatc ttctcagacc agcagctaat   3660

gttactccca caaagggttc ttctaataca gaatttaagt caaccaaaga aggattttcc   3720

atccctgtgt ctgctgatgg atttaaattt ggcatttcgg aaccaggaaa tcaagaaaag   3780

aaaagtgaaa agcctcttga aaatgatact ggcttacagg ctcaggatat tagtggccgg   3840

aagaagggcc gtggtgtgat ttttggccaa acaagtagca cttttacatt tgcagatgtt   3900

gcaaaatcaa cttcaggaga aggatttcag tttggcaaaa aagacctcaa tttcaaggga   3960

ttttcaggtg ctggagaaaa attattctca tcacaatacg gtaaaatggc caataaagca   4020

aacacttccg gtgactttga gaaagatgat gatgcctata agactgagga cagcgatgac   4080

atccattttg aaccagtagt tcaaatgcct gaaaaagtag aacttgtaac aggagaagaa   4140

ggtgaaaaag ttctgtattc acagggggta aaactattta gatttgatgc tgaggtaagt   4200

cagtggaaag aaaggggctt ggggaactta aaaattctca aaaacgaggt caatggcaaa   4260

gtaagaatgc tgatgcaaag agaacaagta ctaaaagtgt gtgctaatca ttggataacg   4320

actacaatga acctgaagcc cctctctgga tcagatagag catggatgtg gtcagccagt   4380

gatttctctg atggtgatgc caaactagag cgattggcag caaaatttaa aacaccagag   4440

ctggctgaag aattcaagca gaaatttgag gaatgccagc ggcttctgtt agacatacca   4500

cttcaaactc cccataaact tgtagatact ggcagagctg ccaagttaat acagagagct   4560

gaagaaatga agagtggact gaaagatttc aaaacatttt tgacaaatga tcaaacaaaa   4620

gtcgctgagg aagaaaataa gggttcaggt acaggtgcgg ccggtgcctc agacacaaca   4680

ataaaaccca atgctgaaaa cactgggccc acattagaat gggataacta tgatttaagg   4740

gaagatgctt tggatgatag tgtcagtagt agctcagtac atgcttctcc attggcaagt   4800

agccctgtga gaaaaaatct tttccacttt gatgagtcaa caacaggatc taacttcagt   4860

tttaaatctg ctttgagtct atctaagtct cctgccaagt tgaatcagag tgggacttca   4920

gttggcactg atgaagaatc tgatgttact caagaagaag agagagatgg acagtacttt   4980

gaacctgttg ttcctttacc tgatctagtt gaagtatcca gtggtgagga aaatgaacaa   5040

gttgttttta gtcacagggc agaattctac agatatgata aagatgttgg tcaatggaaa   5100

gaaaggggca ttggtgatat aaagatttta cagaattatg ataataagca cgttcgtata   5160

ctgatgagaa gggaccaagt attaaaactt tgtgccaatc acagaataac tccagacatg   5220

agtttgcaaa atatgaaagg gacagaaaga gtatgggtgt ggactgcatg tgattttgca   5280

gatggagaaa gaaaagtaga gcatttagct gttcgtttta aactacagga tgttgcagac   5340

tcgtttaaga aaatttttga tgaagcaaaa acagcccagg aaaaagattc tttgataaca   5400

cctcatgttt ctcggtcaag cactcccaga gagtcaccat gtggcaaaat tgctgtagct   5460

gtattagaag aaaccacaag agagaggaca gatgttattc agggtgatga tgtagcagat   5520

gcagcttcag aagttgaagt gtctagcaca tctgaaacaa caacaaaagc agtggtttct   5580

cctccaaagt ttgtatttgg ttcagagtct gttaaaagaa tttttagtag tgaaaaatca   5640

aaaccatttg catttggcaa cagttctgcc actgggtctt tgtttggatt tagttttaat   5700

gcacctttga aaagtaacaa tagtgaaact agttcagtag cccagagtgg atctgaaagc   5760

aaagtggaac ctaaaaaatg tgaactgtca aagaactctg atatcgaaca gtcttcagat   5820

agcaaagtca aaaatctctc tgcttccttt ccaacggaag aatcttcaat caactacaca   5880

tttaaaacac cagaaaagga gcctccatta tggtatgctg aatttactaa agaagaattg   5940

gttcagaagc tcagttccac cacaaaaagt gcagatcact taaacggcct gcttcgggaa   6000

atagaggcaa ccaatgcagt ccttatggag caaattaagc ttctcaaaag tgaaataaga   6060

agattggaaa ggaatcaaga gcaagaggtg tctgcagcta acgtggaaca cttgaagaac   6120

gtcttgctgc agttcatttt cttgaagcca ggtagtgaaa gagagagact tcttcctgtt   6180

ataaatacga tgttgcagct cagccttgaa gaaaagggaa aacttgctgc ggttgctcaa   6240

ggtgaggaat aaaatgcttc ccgttcttct ggatgggcat cctatcttcg tagttggttt   6300

ggacttcgat aggttgatgg aaggaatgtt tttattaacc aaataaaatc tatttacaaa   6360

aatggttcat gtgtattacc atcattcttt tgtcaaaaag tgtgtatatg tttgcattta   6420

catatatttg tacatctata tgacagatgt attttaaaag tttcaacttg aagtaaaagt   6480

acaacagctt gaagtgttga taccaggcca cagccctcta actcatgtga tctcccatgc   6540

atgctgccag aataaaacca ccaggaatga attcactccc cacttctctg gaacctcagg   6600

acccgcccat ttctcggcag tactgtgaat tttgaagtta aactaaattt tggtaccata   6660

ccaactggaa tttaggcttt aaaaataatg tttcaaggcc aggtgtggtg attcatgcct   6720

gaaatcccac tacttgggga ggctgaggct ggagaatcgt ttgaggctag tgagctgtga   6780

ttgtatcact gcactccagc tcggggaaca gagcgagacc ttgtctctaa aaataataat   6840

agtaataaaa ataacatttt atgactattt attgcaaggt cagatttaca gattgttata   6900

aattgttgag aaatttttgt gattagaata tgaaggaaaa agctttgttg gtaaaagtga   6960

catgttaagg ggctatgaag taaatatgct gcagttaatt gtgctaagtt aaaatacagt   7020

ttagttattt gctttaaaat aaactcttct ttttttcttt aaagtatact atctcaaaac   7080

tcattatgtt gtcagagccc tagagctggc tagtgtaaca ctgactatga ataggtgggc   7140

ccaccacttg agttgaggtg atttcatggt gtctttccag gctcttgata gggtgtcact   7200

gcatgcaagc catgaatctg ttttgagaat cctctccatt ttcccaaata aaaacctatc   7260

ccaacagtga ctatatcact cagcattgaa tctaaatata aaagtggtgc tttcagtgtt   7320

tttggcagat agtgttccat aagctttcca tcagaaggga ttttagacac cttagaggtc   7380

cgtgctacat cttcacagtt cctctgaata accttaggtg gtagtgttac ttgcctttga   7440

caccgctgca tatgttttaa tgactagatc caaactgtgt tgttcttaaa tcaaaaattg   7500

gataattttt aatatttatg tattaatcac atagtatgct ctctgaagtt ctcttaagcc   7560

ttcagtttat actcttaatt ttctttctga gctggggaac tgactttgca ctttggttac   7620

acagaacatt ggtttccaat ttagtttaac tgaaatttgc tgctgatatg ttgagtttgt   7680

tctttaaaaa atatctcata tatctcgtct ttcctcctta gaagaacaga cctaactagc   7740

gaatgtatga atgaaaatgc atctatttca gagccgacat gaagagttta gtttttttac   7800

tttataaact gtgaatatga gtatgccagc tgcatacgat gtaactaatc atatttaaat   7860

atatttcact ttctctttga cttgagacct tttgaagtct gtataaactt gttttgaaat   7920

atagtctcca cttacaaatg tcataacaaa atactttttt gcatgataaa aaattgatta   7980

caaaaggcat attctttcat ggtttctgca atgagaggaa gtgtaatgat tattttaata   8040

tttctattaa atatgtttaa ctgtatattt ttat                               8074


<210>  4406
<211>  945
<212>  PRT
<213>  Homosapiens

<400>  4406

Met Ile Arg Gln Glu Val Lys Ala Ile Lys Glu Glu Met Gln Glu Leu 
1               5                   10                  15      


Lys Leu Asn Ser Ser Lys Ser Ala Ser His His Arg Trp Pro Thr Glu 
            20                  25                  30          


Asn Tyr Gly Pro Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr 
        35                  40                  45              


Phe His Gly Ala Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr 
    50                  55                  60                  


Tyr Ser Gln Ser Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala 
65                  70                  75                  80  


Ala Asn Val Thr Pro Thr Lys Gly Ser Ser Asn Thr Glu Phe Lys Ser 
                85                  90                  95      


Thr Lys Glu Gly Phe Ser Ile Pro Val Ser Ala Asp Gly Phe Lys Phe 
            100                 105                 110         


Gly Ile Ser Glu Pro Gly Asn Gln Glu Lys Lys Ser Glu Lys Pro Leu 
        115                 120                 125             


Glu Asn Asp Thr Gly Leu Gln Ala Gln Asp Ile Ser Gly Arg Lys Lys 
    130                 135                 140                 


Gly Arg Gly Val Ile Phe Gly Gln Thr Ser Ser Thr Phe Thr Phe Ala 
145                 150                 155                 160 


Asp Val Ala Lys Ser Thr Ser Gly Glu Gly Phe Gln Phe Gly Lys Lys 
                165                 170                 175     


Asp Leu Asn Phe Lys Gly Phe Ser Gly Ala Gly Glu Lys Leu Phe Ser 
            180                 185                 190         


Ser Gln Tyr Gly Lys Met Ala Asn Lys Ala Asn Thr Ser Gly Asp Phe 
        195                 200                 205             


Glu Lys Asp Asp Asp Ala Tyr Lys Thr Glu Asp Ser Asp Asp Ile His 
    210                 215                 220                 


Phe Glu Pro Val Val Gln Met Pro Glu Lys Val Glu Leu Val Thr Gly 
225                 230                 235                 240 


Glu Glu Gly Glu Lys Val Leu Tyr Ser Gln Gly Val Lys Leu Phe Arg 
                245                 250                 255     


Phe Asp Ala Glu Val Ser Gln Trp Lys Glu Arg Gly Leu Gly Asn Leu 
            260                 265                 270         


Lys Ile Leu Lys Asn Glu Val Asn Gly Lys Val Arg Met Leu Met Gln 
        275                 280                 285             


Arg Glu Gln Val Leu Lys Val Cys Ala Asn His Trp Ile Thr Thr Thr 
    290                 295                 300                 


Met Asn Leu Lys Pro Leu Ser Gly Ser Asp Arg Ala Trp Met Trp Ser 
305                 310                 315                 320 


Ala Ser Asp Phe Ser Asp Gly Asp Ala Lys Leu Glu Arg Leu Ala Ala 
                325                 330                 335     


Lys Phe Lys Thr Pro Glu Leu Ala Glu Glu Phe Lys Gln Lys Phe Glu 
            340                 345                 350         


Glu Cys Gln Arg Leu Leu Leu Asp Ile Pro Leu Gln Thr Pro His Lys 
        355                 360                 365             


Leu Val Asp Thr Gly Arg Ala Ala Lys Leu Ile Gln Arg Ala Glu Glu 
    370                 375                 380                 


Met Lys Ser Gly Leu Lys Asp Phe Lys Thr Phe Leu Thr Asn Asp Gln 
385                 390                 395                 400 


Thr Lys Val Ala Glu Glu Glu Asn Lys Gly Ser Gly Thr Gly Ala Ala 
                405                 410                 415     


Gly Ala Ser Asp Thr Thr Ile Lys Pro Asn Ala Glu Asn Thr Gly Pro 
            420                 425                 430         


Thr Leu Glu Trp Asp Asn Tyr Asp Leu Arg Glu Asp Ala Leu Asp Asp 
        435                 440                 445             


Ser Val Ser Ser Ser Ser Val His Ala Ser Pro Leu Ala Ser Ser Pro 
    450                 455                 460                 


Val Arg Lys Asn Leu Phe His Phe Asp Glu Ser Thr Thr Gly Ser Asn 
465                 470                 475                 480 


Phe Ser Phe Lys Ser Ala Leu Ser Leu Ser Lys Ser Pro Ala Lys Leu 
                485                 490                 495     


Asn Gln Ser Gly Thr Ser Val Gly Thr Asp Glu Glu Ser Asp Val Thr 
            500                 505                 510         


Gln Glu Glu Glu Arg Asp Gly Gln Tyr Phe Glu Pro Val Val Pro Leu 
        515                 520                 525             


Pro Asp Leu Val Glu Val Ser Ser Gly Glu Glu Asn Glu Gln Val Val 
    530                 535                 540                 


Phe Ser His Arg Ala Glu Phe Tyr Arg Tyr Asp Lys Asp Val Gly Gln 
545                 550                 555                 560 


Trp Lys Glu Arg Gly Ile Gly Asp Ile Lys Ile Leu Gln Asn Tyr Asp 
                565                 570                 575     


Asn Lys His Val Arg Ile Leu Met Arg Arg Asp Gln Val Leu Lys Leu 
            580                 585                 590         


Cys Ala Asn His Arg Ile Thr Pro Asp Met Ser Leu Gln Asn Met Lys 
        595                 600                 605             


Gly Thr Glu Arg Val Trp Val Trp Thr Ala Cys Asp Phe Ala Asp Gly 
    610                 615                 620                 


Glu Arg Lys Val Glu His Leu Ala Val Arg Phe Lys Leu Gln Asp Val 
625                 630                 635                 640 


Ala Asp Ser Phe Lys Lys Ile Phe Asp Glu Ala Lys Thr Ala Gln Glu 
                645                 650                 655     


Lys Asp Ser Leu Ile Thr Pro His Val Ser Arg Ser Ser Thr Pro Arg 
            660                 665                 670         


Glu Ser Pro Cys Gly Lys Ile Ala Val Ala Val Leu Glu Glu Thr Thr 
        675                 680                 685             


Arg Glu Arg Thr Asp Val Ile Gln Gly Asp Asp Val Ala Asp Ala Ala 
    690                 695                 700                 


Ser Glu Val Glu Val Ser Ser Thr Ser Glu Thr Thr Thr Lys Ala Val 
705                 710                 715                 720 


Val Ser Pro Pro Lys Phe Val Phe Gly Ser Glu Ser Val Lys Arg Ile 
                725                 730                 735     


Phe Ser Ser Glu Lys Ser Lys Pro Phe Ala Phe Gly Asn Ser Ser Ala 
            740                 745                 750         


Thr Gly Ser Leu Phe Gly Phe Ser Phe Asn Ala Pro Leu Lys Ser Asn 
        755                 760                 765             


Asn Ser Glu Thr Ser Ser Val Ala Gln Ser Gly Ser Glu Ser Lys Val 
    770                 775                 780                 


Glu Pro Lys Lys Cys Glu Leu Ser Lys Asn Ser Asp Ile Glu Gln Ser 
785                 790                 795                 800 


Ser Asp Ser Lys Val Lys Asn Leu Ser Ala Ser Phe Pro Thr Glu Glu 
                805                 810                 815     


Ser Ser Ile Asn Tyr Thr Phe Lys Thr Pro Glu Lys Glu Pro Pro Leu 
            820                 825                 830         


Trp Tyr Ala Glu Phe Thr Lys Glu Glu Leu Val Gln Lys Leu Ser Ser 
        835                 840                 845             


Thr Thr Lys Ser Ala Asp His Leu Asn Gly Leu Leu Arg Glu Ile Glu 
    850                 855                 860                 


Ala Thr Asn Ala Val Leu Met Glu Gln Ile Lys Leu Leu Lys Ser Glu 
865                 870                 875                 880 


Ile Arg Arg Leu Glu Arg Asn Gln Glu Gln Glu Val Ser Ala Ala Asn 
                885                 890                 895     


Val Glu His Leu Lys Asn Val Leu Leu Gln Phe Ile Phe Leu Lys Pro 
            900                 905                 910         


Gly Ser Glu Arg Glu Arg Leu Leu Pro Val Ile Asn Thr Met Leu Gln 
        915                 920                 925             


Leu Ser Leu Glu Glu Lys Gly Lys Leu Ala Ala Val Ala Gln Gly Glu 
    930                 935                 940                 


Glu 
945 


<210>  4407
<211>  2556
<212>  DNA
<213>  Homosapiens

<400>  4407
ggcgcgatga gttgcagcaa ggcctacggg gagcggtacg tcgcctcggt gcagggctcc     60

gccccgtcgc ctcgaaagaa gtcaacgaga ggattctatt ttgcaaagct gtattatgaa    120

gctaaagaat atgatcttgc taaaaaatac atatgtactt acattaatgt gcgagagatg    180

gatcccagag ctcacagatt tctgggtctt ctttatgaat tggaagaaaa cacagagaaa    240

gccgttgaat gttacaggcg ttcagtggaa ttaaacccaa cacaaaaaga tcttgtgttg    300

aagattgcag aattgctttg taaaaatgat gttactgatg gaagagcaga atactgggtg    360

gaaagagcag caaaactttt cccaggaagt cctgcaattt ataaactaaa ggaacagctt    420

ctagattgtg aaggtgaaga tggatggaat aaactttttg acttgattca gtcagaactt    480

tatgtaagac ctgatgacgt ccatgtgaac atccggctag tggagttgta tcgctcaact    540

aaaagattga aggatgctgt ggcccgctgc catgaggcag agaggaacat agctttgcgt    600

tcaagtttag agtggaattc gtgtgttgta cagaccctta aggaatatct ggagtcttta    660

cagtgtttgg agtctgataa aagtgactgg cgagcaacca atacagactt actgctggcc    720

tatgctaatc ttatgcttct tacgctttcc actagagatg tgcaggaaag tagagaatta    780

ctggaaagtt ttgatagtgc tcttcagtct gcgaaatctt ctttgggtgg aaatgatgaa    840

ctgtcagcta ctttcttaga aatgaaagga catttctaca tgcatgctgg ttctctgctc    900

ttgaagatgg gtcagcatgg taataatgtt caatggcgag ctctttctga gctggctgca    960

ttgtgctatc tcatagcatt tcaggttcca agaccaaaga ttaaattaat aaaaggtgaa   1020

gctggacaaa atctgctgga aatgatggcc tgtgaccgac tgagccaatc agggcacatg   1080

ttgctaaact taagtcgtgg caagcaagat tttttaaaag tggttgttga aacttttgcc   1140

aacaaaagcg ggcagtctgc attatatgat gctctgtttt ctagtcagtc acctaaggat   1200

acatcttttc ttggtagcga tgatattgga aacattgatg tacaagaacc agagcttgaa   1260

gatttggcta gatacgatgt tggtgctatt cgagcacata atggtagtct tcagcacctt   1320

acttggcttg gcttacagtg gaattcattg cctgctttac ctggaatccg aaaatggcta   1380

aaacagcttt tccatcattt gccccaggaa acctcaaggc ttgaaacaaa tgcacctgaa   1440

tcaatatgta ttttagatct tgaagtattt ctccttggag tagtatatac cagccactta   1500

caattaaagg agaaatgtaa ttctcaccac agctcctatc agccgttatg cctgcccctt   1560

cctgtgtgta aacagctttg tacagaaaga caaaaatctt ggtgggatgc ggtttgtact   1620

ctgattcaca gaaaagcagt acctggaaac tcagcaaaat tgagacttct agttcagcat   1680

gaaataaaca ctctaagagc ccaggaaaaa catggccttc aacctgctct gcttgtacat   1740

tgggcaaaat gccttcagaa aatgggcagc ggtcttaatt ctttttatga tcaacgagaa   1800

tacataggga gaagtgttca ttattggaag aaagttttgc cattgttgaa gataataaaa   1860

aagaagaaca gtattcctga acctattgat cctctgttta aacattttca tagtgtagac   1920

attcaggcat cagaaattgt tgaatatgaa gaagacgcac acgtaacttt tgctatattg   1980

gatgcagtaa atggaaatat agaagatgct atgactgctt ttgaatctat aaaaagtgtt   2040

gtttcttatt ggaatcttgc actgattttt cacaggaagg cagaagacat tgcaaatgat   2100

gccctttctc ctgaagaaca agaagaatgc aaaaattatc tgagaaagac caggggctac   2160

ctaataaaga ttttagatga cagtgattca aatctttcag tggtcaagaa attgcctgtg   2220

cccctggagt ctgtaaaaga gatgcttaag tcagtcatgc aggaactcga aaactatagt   2280

gaaggaggtc ctctctataa aaatggttct ttgcgaaatg cggattcaga aataaaacat   2340

tctacaccat ctcctaccaa atattcacta tcaccaagta aaagttacaa ggtaaacagg   2400

aaagaatgga atcatttcat tgtgaaattg tttctaagtg ttttaaatgc tcttttgtta   2460

tttttatttt ttttttagta ttctcccaaa acaccacctc gatgggcaga agatcagaat   2520

tctttactga aaatgattcg ccaagaagta aaggcc                             2556


<210>  4408
<211>  823
<212>  PRT
<213>  Homosapiens

<400>  4408

Met Ser Cys Ser Lys Ala Tyr Gly Glu Arg Tyr Val Ala Ser Val Gln 
1               5                   10                  15      


Gly Ser Ala Pro Ser Pro Arg Lys Lys Ser Thr Arg Gly Phe Tyr Phe 
            20                  25                  30          


Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 
        35                  40                  45              


Ile Cys Thr Tyr Ile Asn Val Arg Glu Met Asp Pro Arg Ala His Arg 
    50                  55                  60                  


Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Glu Lys Ala Val 
65                  70                  75                  80  


Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 
                85                  90                  95      


Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 
            100                 105                 110         


Arg Ala Glu Tyr Trp Val Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 
        115                 120                 125             


Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 
    130                 135                 140                 


Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 
145                 150                 155                 160 


Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Leu Tyr Arg 
                165                 170                 175     


Ser Thr Lys Arg Leu Lys Asp Ala Val Ala Arg Cys His Glu Ala Glu 
            180                 185                 190         


Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 
        195                 200                 205             


Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 
    210                 215                 220                 


Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 
225                 230                 235                 240 


Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg 
                245                 250                 255     


Glu Leu Leu Glu Ser Phe Asp Ser Ala Leu Gln Ser Ala Lys Ser Ser 
            260                 265                 270         


Leu Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly 
        275                 280                 285             


His Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His 
    290                 295                 300                 


Gly Asn Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys 
305                 310                 315                 320 


Tyr Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys 
                325                 330                 335     


Gly Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu 
            340                 345                 350         


Ser Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp 
        355                 360                 365             


Phe Leu Lys Val Val Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser 
    370                 375                 380                 


Ala Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser 
385                 390                 395                 400 


Phe Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Gln Glu Pro Glu 
                405                 410                 415     


Leu Glu Asp Leu Ala Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn 
            420                 425                 430         


Gly Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu 
        435                 440                 445             


Pro Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His 
    450                 455                 460                 


Leu Pro Gln Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile 
465                 470                 475                 480 


Cys Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser 
                485                 490                 495     


His Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln 
            500                 505                 510         


Pro Leu Cys Leu Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg 
        515                 520                 525             


Gln Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala 
    530                 535                 540                 


Val Pro Gly Asn Ser Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile 
545                 550                 555                 560 


Asn Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu 
                565                 570                 575     


Val His Trp Ala Lys Cys Leu Gln Lys Met Gly Ser Gly Leu Asn Ser 
            580                 585                 590         


Phe Tyr Asp Gln Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys 
        595                 600                 605             


Lys Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro 
    610                 615                 620                 


Glu Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln 
625                 630                 635                 640 


Ala Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Val Thr Phe Ala 
                645                 650                 655     


Ile Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Met Thr Ala Phe 
            660                 665                 670         


Glu Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe 
        675                 680                 685             


His Arg Lys Ala Glu Asp Ile Ala Asn Asp Ala Leu Ser Pro Glu Glu 
    690                 695                 700                 


Gln Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr Arg Gly Tyr Leu Ile 
705                 710                 715                 720 


Lys Ile Leu Asp Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu 
                725                 730                 735     


Pro Val Pro Leu Glu Ser Val Lys Glu Met Leu Lys Ser Val Met Gln 
            740                 745                 750         


Glu Leu Glu Asn Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser 
        755                 760                 765             


Leu Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr 
    770                 775                 780                 


Lys Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Val Asn Arg Lys Glu 
785                 790                 795                 800 


Trp Asn His Phe Ile Val Lys Leu Phe Leu Ser Val Leu Asn Ala Leu 
                805                 810                 815     


Leu Leu Phe Leu Phe Phe Phe 
            820             


<210>  4409
<211>  6024
<212>  DNA
<213>  Homosapiens

<400>  4409
ggcgcgatga gttgcagcaa ggcctacggg gagcggtacg tcgcctcggt gcagggctcc     60

gccccgtcgc ctcgaaagaa gtcaacgaga ggattctatt ttgcaaagct gtattatgaa    120

gctaaagaat atgatcttgc taaaaaatac atatgtactt acattaatgt gcgagagatg    180

gatcccagag ctcacagatt tctgggtctt ctttatgaat tggaagaaaa cacagagaaa    240

gccgttgaat gttacaggcg ttcagtggaa ttaaacccaa cacaaaaaga tcttgtgttg    300

aagattgcag aattgctttg taaaaatgat gttactgatg gaagagcaga atactgggtg    360

gaaagagcag caaaactttt cccaggaagt cctgcaattt ataaactaaa ggaacagctt    420

ctagattgtg aaggtgaaga tggatggaat aaactttttg acttgattca gtcagaactt    480

tatgtaagac ctgatgacgt ccatgtgaac atccggctag tggagttgta tcgctcaact    540

aaaagattga aggatgctgt ggcccgctgc catgaggcag agaggaacat agctttgcgt    600

tcaagtttag agtggaattc gtgtgttgta cagaccctta aggaatatct ggagtcttta    660

cagtgtttgg agtctgataa aagtgactgg cgagcaacca atacagactt actgctggcc    720

tatgctaatc ttatgcttct tacgctttcc actagagatg tgcaggaaag tagagaatta    780

ctggaaagtt ttgatagtgc tcttcagtct gcgaaatctt ctttgggtgg aaatgatgaa    840

ctgtcagcta ctttcttaga aatgaaagga catttctaca tgcatgctgg ttctctgctc    900

ttgaagatgg gtcagcatgg taataatgtt caatggcgag ctctttctga gctggctgca    960

ttgtgctatc tcatagcatt tcaggttcca agaccaaaga ttaaattaat aaaaggtgaa   1020

gctggacaaa atctgctgga aatgatggcc tgtgaccgac tgagccaatc agggcacatg   1080

ttgctaaact taagtcgtgg caagcaagat tttttaaaag tggttgttga aacttttgcc   1140

aacaaaagcg ggcagtctgc attatatgat gctctgtttt ctagtcagtc acctaaggat   1200

acatcttttc ttggtagcga tgatattgga aacattgatg tacaagaacc agagcttgaa   1260

gatttggcta gatacgatgt tggtgctatt cgagcacata atggtagtct tcagcacctt   1320

acttggcttg gcttacagtg gaattcattg cctgctttac ctggaatccg aaaatggcta   1380

aaacagcttt tccatcattt gccccaggaa acctcaaggc ttgaaacaaa tgcacctgaa   1440

tcaatatgta ttttagatct tgaagtattt ctccttggag tagtatatac cagccactta   1500

caattaaagg agaaatgtaa ttctcaccac agctcctatc agccgttatg cctgcccctt   1560

cctgtgtgta aacagctttg tacagaaaga caaaaatctt ggtgggatgc ggtttgtact   1620

ctgattcaca gaaaagcagt acctggaaac tcagcaaaat tgagacttct agttcagcat   1680

gaaataaaca ctctaagagc ccaggaaaaa catggccttc aacctgctct gcttgtacat   1740

tgggcaaaat gccttcagaa aatgggcagc ggtcttaatt ctttttatga tcaacgagaa   1800

tacataggga gaagtgttca ttattggaag aaagttttgc cattgttgaa gataataaaa   1860

aagaagaaca gtattcctga acctattgat cctctgttta aacattttca tagtgtagac   1920

attcaggcat cagaaattgt tgaatatgaa gaagacgcac acgtaacttt tgctatattg   1980

gatgcagtaa atggaaatat agaagatgct atgactgctt ttgaatctat aaaaagtgtt   2040

gtttcttatt ggaatcttgc actgattttt cacaggaagg cagaagacat tgcaaatgat   2100

gccctttctc ctgaagaaca agaagaatgc aaaaattatc tgagaaagac caggggctac   2160

ctaataaaga ttttagatga cagtgattca aatctttcag tggtcaagaa attgcctgtg   2220

cccctggagt ctgtaaaaga gatgcttaag tcagtcatgc aggaactcga aaactatagt   2280

gaaggaggtc ctctctataa aaatggttct ttgcgaaatg cggattcaga aataaaacat   2340

tctacaccat ctcctaccaa atattcacta tcaccaagta aaagttacaa gtattctccc   2400

aaaacaccac ctcgatgggc agaagatcag aattctttac tgaaaatgat tcgccaagaa   2460

gtaaaggcca ttaaggaaga aatgcaggag ttgaaactaa atagcagtaa gtcagcatcc   2520

catcatcgtt ggcccacaga gaattatgga ccagactcgg tgcctgatgg atatcagggg   2580

tcacagacat ttcatggggc tccactaaca gttgcaacta ctggcccttc agtatattat   2640

agtcagtcac cagcatataa ttcccagtat cttctcagac cagcagctaa tgttactccc   2700

acaaagggtt cttctaatac agaatttaag tcaaccaaag aaggattttc catccctgtg   2760

tctgctgatg gatttaaatt tggcatttcg gaaccaggaa atcaagaaaa gaaaagtgaa   2820

aagcctcttg aaaatgatac tggcttacag gctcaggata ttagtggccg gaagaagggc   2880

cgtggtgtga tttttggcca aacaagtagc acttttacat ttgcagatgt tgcaaaatca   2940

acttcaggag aaggatttca gtttggcaaa aaagacctca atttcaaggg attttcaggt   3000

gctggagaaa aattattctc atcacaatac ggtaaaatgg ccaataaagc aaacacttcc   3060

ggtgactttg agaaagatga tgatgcctat aagactgagg acagcgatga catccatttt   3120

gaaccagtag ttcaaatgcc tgaaaaagta gaacttgtaa caggagaaga aggtgaaaaa   3180

gttctgtatt cacagggggt aaaactattt agatttgatg ctgaggtaag tcagtggaaa   3240

gaaaggggct tggggaactt aaaaattctc aaaaacgagg tcaatggcaa agtaagaatg   3300

ctgatgcaaa gagaacaagt actaaaagtg tgtgctaatc attggataac gactacaatg   3360

aacctgaagc ccctctctgg atcagataga gcatggatgt ggtcagccag tgatttctct   3420

gatggtgatg ccaaactaga gcgattggca gcaaaattta aaacaccaga gctggctgaa   3480

gaattcaagc agaaatttga ggaatgccag cggcttctgt tagacatacc acttcaaact   3540

ccccataaac ttgtagatac tggcagagct gccaagttaa tacagagagc tgaagaaatg   3600

aagagtggac tgaaagattt caaaacattt ttgacaaatg atcaaacaaa agtcgctgag   3660

gaagaaaata agggttcagg tacaggtgcg gccggtgcct cagacacaac aataaaaccc   3720

aatgctgaaa acactgggcc cacattagaa tgggataact atgatttaag ggaagatgct   3780

ttggatgata gtgtcagtag tagctcagta catgcttctc cattggcaag tagccctgtg   3840

agaaaaaatc ttttccactt tgatgagtca acaacaggat ctaacttcag ttttaaatct   3900

gctttgagtc tatctaagtc tcctgccaag ttgaatcaga gtgggacttc agttggcact   3960

gatgaagaat ctgatgttac tcaagaagaa gagagagatg gacagtactt tgaacctgtt   4020

gttcctttac ctgatctagt tgaagtatcc agtggtgagg aaaatgaaca agttgttttt   4080

agtcacaggg cagaattcta cagatatgat aaagatgttg gtcaatggaa agaaaggggc   4140

attggtgata taaagatttt acagaattat gataataagc acgttcgtat actgatgaga   4200

agggaccaag tattaaaact ttgtgccaat cacagaataa ctccagacat gagtttgcaa   4260

aatatgaaag ggacagaaag agtatgggtg tggactgcat gtgattttgc agatggagaa   4320

agaaaagtag agcatttagc tgttcgtttt aaactacagg atgttgcaga ctcgtttaag   4380

aaaatttttg atgaagcaaa aacagcccag gaaaaagatt ctttgataac acctcatgtt   4440

tctcggtcaa gcactcccag agagtcacca tgtggcaaaa ttgctgtagc tgtattagaa   4500

gaaaccacaa gagagaggac agatgttatt cagggtgatg atgtagcaga tgcagcttca   4560

gaagttgaag tgtctagcac atctgaaaca acaacaaaag cagtggtttc tcctccaaag   4620

tttgtatttg gttcagagtc tgttaaaaga atttttagta gtgaaaaatc aaaaccattt   4680

gcatttggca acagttctgc cactgggtct ttgtttggat ttagttttaa tgcacctttg   4740

aaaagtaaca atagtgaaac tagttcagta gcccagagtg gatctgaaag caaagtggaa   4800

cctaaaaaat gtgaactgtc aaagaactct gatatcgaac agtcttcaga tagcaaagtc   4860

aaaaatctct ctgcttcctt tccaacggaa gaatcttcaa tcaactacac atttaaaaca   4920

ccagaaaagg agcctccatt atggtatgct gaatttacta aagaagaatt ggttcagaag   4980

ctcagttcca ccacaaaaag tgcagatcac ttaaacggcc tgcttcggga aatagaggca   5040

accaatgcag tccttatgga gcaaattaag cttctcaaaa gtgaaataag aagattggaa   5100

aggaatcaag agcaagaggt gtctgcagct aacgtggaac acttgaagaa cgtcttgctg   5160

cagttcattt tcttgaagcc aggtagtgaa agagagagac ttcttcctgt tataaatacg   5220

atgttgcagc tcagccttga agaaaaggga aaacttgctg cggttgctca aggtgggtaa   5280

aaggagagtc tcagaacttc tgacttctaa cttaaactaa acagcctggt ggttgagaag   5340

ttgtctgtat gtgtaacttt tcaattttgc tcatttgaat tgggtctgtc atatgagtag   5400

gccgtgacta gatttgaaaa gctgactttt taacatcttg aggcaaatgt agtacattta   5460

tataatttta acgttcagca aaatacaata agtgcttagc ttgatcttct agctctttga   5520

aaattggatt tttatcctgg tgttgcgttc tggtgttcag ctgaacgtgg ttttgtttta   5580

aattctactt tttaaaaaac atttattagc ttgttccttt tctacttcac ccctcttcct   5640

tcctccaacc ccaaatagct taagacaatg gagccataga gcccaacact tggtctatat   5700

acagcagtcc actttctagg caaatgcagt tttaaaactg tgccataggc caggcgccgg   5760

tggttcacac ctataatccc accactttgg gaggccgagg caggcggatc acaagatcaa   5820

gataccgaga ccatcctggc caacatggtg aaatctcgtc tctactaaaa atacaaaaat   5880

tagctggacg tggtggcatg cgcctgtagt cccagctact caggaggctg aggcaggaga   5940

gtcacttgaa ctcacgaggc ggaggttgca gtgatctgtc acaccactgt actccagcct   6000

gacggcagag cgagactcca tctc                                          6024


<210>  4410
<211>  1757
<212>  PRT
<213>  Homosapiens

<400>  4410

Met Ser Cys Ser Lys Ala Tyr Gly Glu Arg Tyr Val Ala Ser Val Gln 
1               5                   10                  15      


Gly Ser Ala Pro Ser Pro Arg Lys Lys Ser Thr Arg Gly Phe Tyr Phe 
            20                  25                  30          


Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 
        35                  40                  45              


Ile Cys Thr Tyr Ile Asn Val Arg Glu Met Asp Pro Arg Ala His Arg 
    50                  55                  60                  


Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Glu Lys Ala Val 
65                  70                  75                  80  


Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 
                85                  90                  95      


Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 
            100                 105                 110         


Arg Ala Glu Tyr Trp Val Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 
        115                 120                 125             


Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 
    130                 135                 140                 


Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 
145                 150                 155                 160 


Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Leu Tyr Arg 
                165                 170                 175     


Ser Thr Lys Arg Leu Lys Asp Ala Val Ala Arg Cys His Glu Ala Glu 
            180                 185                 190         


Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 
        195                 200                 205             


Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 
    210                 215                 220                 


Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 
225                 230                 235                 240 


Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg 
                245                 250                 255     


Glu Leu Leu Glu Ser Phe Asp Ser Ala Leu Gln Ser Ala Lys Ser Ser 
            260                 265                 270         


Leu Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly 
        275                 280                 285             


His Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His 
    290                 295                 300                 


Gly Asn Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys 
305                 310                 315                 320 


Tyr Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys 
                325                 330                 335     


Gly Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu 
            340                 345                 350         


Ser Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp 
        355                 360                 365             


Phe Leu Lys Val Val Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser 
    370                 375                 380                 


Ala Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser 
385                 390                 395                 400 


Phe Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Gln Glu Pro Glu 
                405                 410                 415     


Leu Glu Asp Leu Ala Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn 
            420                 425                 430         


Gly Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu 
        435                 440                 445             


Pro Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His 
    450                 455                 460                 


Leu Pro Gln Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile 
465                 470                 475                 480 


Cys Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser 
                485                 490                 495     


His Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln 
            500                 505                 510         


Pro Leu Cys Leu Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg 
        515                 520                 525             


Gln Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala 
    530                 535                 540                 


Val Pro Gly Asn Ser Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile 
545                 550                 555                 560 


Asn Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu 
                565                 570                 575     


Val His Trp Ala Lys Cys Leu Gln Lys Met Gly Ser Gly Leu Asn Ser 
            580                 585                 590         


Phe Tyr Asp Gln Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys 
        595                 600                 605             


Lys Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro 
    610                 615                 620                 


Glu Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln 
625                 630                 635                 640 


Ala Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Val Thr Phe Ala 
                645                 650                 655     


Ile Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Met Thr Ala Phe 
            660                 665                 670         


Glu Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe 
        675                 680                 685             


His Arg Lys Ala Glu Asp Ile Ala Asn Asp Ala Leu Ser Pro Glu Glu 
    690                 695                 700                 


Gln Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr Arg Gly Tyr Leu Ile 
705                 710                 715                 720 


Lys Ile Leu Asp Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu 
                725                 730                 735     


Pro Val Pro Leu Glu Ser Val Lys Glu Met Leu Lys Ser Val Met Gln 
            740                 745                 750         


Glu Leu Glu Asn Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser 
        755                 760                 765             


Leu Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr 
    770                 775                 780                 


Lys Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Lys Thr 
785                 790                 795                 800 


Pro Pro Arg Trp Ala Glu Asp Gln Asn Ser Leu Leu Lys Met Ile Arg 
                805                 810                 815     


Gln Glu Val Lys Ala Ile Lys Glu Glu Met Gln Glu Leu Lys Leu Asn 
            820                 825                 830         


Ser Ser Lys Ser Ala Ser His His Arg Trp Pro Thr Glu Asn Tyr Gly 
        835                 840                 845             


Pro Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly 
    850                 855                 860                 


Ala Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln 
865                 870                 875                 880 


Ser Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val 
                885                 890                 895     


Thr Pro Thr Lys Gly Ser Ser Asn Thr Glu Phe Lys Ser Thr Lys Glu 
            900                 905                 910         


Gly Phe Ser Ile Pro Val Ser Ala Asp Gly Phe Lys Phe Gly Ile Ser 
        915                 920                 925             


Glu Pro Gly Asn Gln Glu Lys Lys Ser Glu Lys Pro Leu Glu Asn Asp 
    930                 935                 940                 


Thr Gly Leu Gln Ala Gln Asp Ile Ser Gly Arg Lys Lys Gly Arg Gly 
945                 950                 955                 960 


Val Ile Phe Gly Gln Thr Ser Ser Thr Phe Thr Phe Ala Asp Val Ala 
                965                 970                 975     


Lys Ser Thr Ser Gly Glu Gly Phe Gln Phe Gly Lys Lys Asp Leu Asn 
            980                 985                 990         


Phe Lys Gly Phe Ser Gly Ala Gly  Glu Lys Leu Phe Ser  Ser Gln Tyr 
        995                 1000                 1005             


Gly Lys  Met Ala Asn Lys Ala  Asn Thr Ser Gly Asp  Phe Glu Lys 
    1010                 1015                 1020             


Asp Asp  Asp Ala Tyr Lys Thr  Glu Asp Ser Asp Asp  Ile His Phe 
    1025                 1030                 1035             


Glu Pro  Val Val Gln Met Pro  Glu Lys Val Glu Leu  Val Thr Gly 
    1040                 1045                 1050             


Glu Glu  Gly Glu Lys Val Leu  Tyr Ser Gln Gly Val  Lys Leu Phe 
    1055                 1060                 1065             


Arg Phe  Asp Ala Glu Val Ser  Gln Trp Lys Glu Arg  Gly Leu Gly 
    1070                 1075                 1080             


Asn Leu  Lys Ile Leu Lys Asn  Glu Val Asn Gly Lys  Val Arg Met 
    1085                 1090                 1095             


Leu Met  Gln Arg Glu Gln Val  Leu Lys Val Cys Ala  Asn His Trp 
    1100                 1105                 1110             


Ile Thr  Thr Thr Met Asn Leu  Lys Pro Leu Ser Gly  Ser Asp Arg 
    1115                 1120                 1125             


Ala Trp  Met Trp Ser Ala Ser  Asp Phe Ser Asp Gly  Asp Ala Lys 
    1130                 1135                 1140             


Leu Glu  Arg Leu Ala Ala Lys  Phe Lys Thr Pro Glu  Leu Ala Glu 
    1145                 1150                 1155             


Glu Phe  Lys Gln Lys Phe Glu  Glu Cys Gln Arg Leu  Leu Leu Asp 
    1160                 1165                 1170             


Ile Pro  Leu Gln Thr Pro His  Lys Leu Val Asp Thr  Gly Arg Ala 
    1175                 1180                 1185             


Ala Lys  Leu Ile Gln Arg Ala  Glu Glu Met Lys Ser  Gly Leu Lys 
    1190                 1195                 1200             


Asp Phe  Lys Thr Phe Leu Thr  Asn Asp Gln Thr Lys  Val Ala Glu 
    1205                 1210                 1215             


Glu Glu  Asn Lys Gly Ser Gly  Thr Gly Ala Ala Gly  Ala Ser Asp 
    1220                 1225                 1230             


Thr Thr  Ile Lys Pro Asn Ala  Glu Asn Thr Gly Pro  Thr Leu Glu 
    1235                 1240                 1245             


Trp Asp  Asn Tyr Asp Leu Arg  Glu Asp Ala Leu Asp  Asp Ser Val 
    1250                 1255                 1260             


Ser Ser  Ser Ser Val His Ala  Ser Pro Leu Ala Ser  Ser Pro Val 
    1265                 1270                 1275             


Arg Lys  Asn Leu Phe His Phe  Asp Glu Ser Thr Thr  Gly Ser Asn 
    1280                 1285                 1290             


Phe Ser  Phe Lys Ser Ala Leu  Ser Leu Ser Lys Ser  Pro Ala Lys 
    1295                 1300                 1305             


Leu Asn  Gln Ser Gly Thr Ser  Val Gly Thr Asp Glu  Glu Ser Asp 
    1310                 1315                 1320             


Val Thr  Gln Glu Glu Glu Arg  Asp Gly Gln Tyr Phe  Glu Pro Val 
    1325                 1330                 1335             


Val Pro  Leu Pro Asp Leu Val  Glu Val Ser Ser Gly  Glu Glu Asn 
    1340                 1345                 1350             


Glu Gln  Val Val Phe Ser His  Arg Ala Glu Phe Tyr  Arg Tyr Asp 
    1355                 1360                 1365             


Lys Asp  Val Gly Gln Trp Lys  Glu Arg Gly Ile Gly  Asp Ile Lys 
    1370                 1375                 1380             


Ile Leu  Gln Asn Tyr Asp Asn  Lys His Val Arg Ile  Leu Met Arg 
    1385                 1390                 1395             


Arg Asp  Gln Val Leu Lys Leu  Cys Ala Asn His Arg  Ile Thr Pro 
    1400                 1405                 1410             


Asp Met  Ser Leu Gln Asn Met  Lys Gly Thr Glu Arg  Val Trp Val 
    1415                 1420                 1425             


Trp Thr  Ala Cys Asp Phe Ala  Asp Gly Glu Arg Lys  Val Glu His 
    1430                 1435                 1440             


Leu Ala  Val Arg Phe Lys Leu  Gln Asp Val Ala Asp  Ser Phe Lys 
    1445                 1450                 1455             


Lys Ile  Phe Asp Glu Ala Lys  Thr Ala Gln Glu Lys  Asp Ser Leu 
    1460                 1465                 1470             


Ile Thr  Pro His Val Ser Arg  Ser Ser Thr Pro Arg  Glu Ser Pro 
    1475                 1480                 1485             


Cys Gly  Lys Ile Ala Val Ala  Val Leu Glu Glu Thr  Thr Arg Glu 
    1490                 1495                 1500             


Arg Thr  Asp Val Ile Gln Gly  Asp Asp Val Ala Asp  Ala Ala Ser 
    1505                 1510                 1515             


Glu Val  Glu Val Ser Ser Thr  Ser Glu Thr Thr Thr  Lys Ala Val 
    1520                 1525                 1530             


Val Ser  Pro Pro Lys Phe Val  Phe Gly Ser Glu Ser  Val Lys Arg 
    1535                 1540                 1545             


Ile Phe  Ser Ser Glu Lys Ser  Lys Pro Phe Ala Phe  Gly Asn Ser 
    1550                 1555                 1560             


Ser Ala  Thr Gly Ser Leu Phe  Gly Phe Ser Phe Asn  Ala Pro Leu 
    1565                 1570                 1575             


Lys Ser  Asn Asn Ser Glu Thr  Ser Ser Val Ala Gln  Ser Gly Ser 
    1580                 1585                 1590             


Glu Ser  Lys Val Glu Pro Lys  Lys Cys Glu Leu Ser  Lys Asn Ser 
    1595                 1600                 1605             


Asp Ile  Glu Gln Ser Ser Asp  Ser Lys Val Lys Asn  Leu Ser Ala 
    1610                 1615                 1620             


Ser Phe  Pro Thr Glu Glu Ser  Ser Ile Asn Tyr Thr  Phe Lys Thr 
    1625                 1630                 1635             


Pro Glu  Lys Glu Pro Pro Leu  Trp Tyr Ala Glu Phe  Thr Lys Glu 
    1640                 1645                 1650             


Glu Leu  Val Gln Lys Leu Ser  Ser Thr Thr Lys Ser  Ala Asp His 
    1655                 1660                 1665             


Leu Asn  Gly Leu Leu Arg Glu  Ile Glu Ala Thr Asn  Ala Val Leu 
    1670                 1675                 1680             


Met Glu  Gln Ile Lys Leu Leu  Lys Ser Glu Ile Arg  Arg Leu Glu 
    1685                 1690                 1695             


Arg Asn  Gln Glu Gln Glu Val  Ser Ala Ala Asn Val  Glu His Leu 
    1700                 1705                 1710             


Lys Asn  Val Leu Leu Gln Phe  Ile Phe Leu Lys Pro  Gly Ser Glu 
    1715                 1720                 1725             


Arg Glu  Arg Leu Leu Pro Val  Ile Asn Thr Met Leu  Gln Leu Ser 
    1730                 1735                 1740             


Leu Glu  Glu Lys Gly Lys Leu  Ala Ala Val Ala Gln  Gly Gly 
    1745                 1750                 1755         


<210>  4411
<211>  7156
<212>  DNA
<213>  Homosapiens

<400>  4411
ggcgcgatga gttgcagcaa ggcctacggg gagcggtacg tcgcctcggt gcagggctcc     60

gccccgtcgc ctcgaaagaa gtcaacgaga ggattctatt ttgcaaagct gtattatgaa    120

gctaaagaat atgatcttgc taaaaaatac atatgtactt acattaatgt gcgagagatg    180

gatcccagag ctcacagatt tctgggtctt ctttatgaat tggaagaaaa cacagagaaa    240

gccgttgaat gttacaggcg ttcagtggaa ttaaacccaa cacaaaaaga tcttgtgttg    300

aagattgcag aattgctttg taaaaatgat gttactgatg gaagagcaga atactgggtg    360

gaaagagcag caaaactttt cccaggaagt cctgcaattt ataaactaaa ggaacagctt    420

ctagattgtg aaggtgaaga tggatggaat aaactttttg acttgattca gtcagaactt    480

tatgtaagac ctgatgacgt ccatgtgaac atccggctag tggagttgta tcgctcaact    540

aaaagattga aggatgctgt ggcccgctgc catgaggcag agaggaacat agctttgcgt    600

tcaagtttag agtggaattc gtgtgttgta cagaccctta aggaatatct ggagtcttta    660

cagtgtttgg agtctgataa aagtgactgg cgagcaacca atacagactt actgctggcc    720

tatgctaatc ttatgcttct tacgctttcc actagagatg tgcaggaaag tagagaatta    780

ctggaaagtt ttgatagtgc tcttcagtct gcgaaatctt ctttgggtgg aaatgatgaa    840

ctgtcagcta ctttcttaga aatgaaagga catttctaca tgcatgctgg ttctctgctc    900

ttgaagatgg gtcagcatgg taataatgtt caatggcgag ctctttctga gctggctgca    960

ttgtgctatc tcatagcatt tcaggttcca agaccaaaga ttaaattaat aaaaggtgaa   1020

gctggacaaa atctgctgga aatgatggcc tgtgaccgac tgagccaatc agggcacatg   1080

ttgctaaact taagtcgtgg caagcaagat tttttaaaag tggttgttga aacttttgcc   1140

aacaaaagcg ggcagtctgc attatatgat gctctgtttt ctagtcagtc acctaaggat   1200

acatcttttc ttggtagcga tgatattgga aacattgatg tacaagaacc agagcttgaa   1260

gatttggcta gatacgatgt tggtgctatt cgagcacata atggtagtct tcagcacctt   1320

acttggcttg gcttacagtg gaattcattg cctgctttac ctggaatccg aaaatggcta   1380

aaacagcttt tccatcattt gccccaggaa acctcaaggc ttgaaacaaa tgcacctgaa   1440

tcaatatgta ttttagatct tgaagtattt ctccttggag tagtatatac cagccactta   1500

caattaaagg agaaatgtaa ttctcaccac agctcctatc agccgttatg cctgcccctt   1560

cctgtgtgta aacagctttg tacagaaaga caaaaatctt ggtgggatgc ggtttgtact   1620

ctgattcaca gaaaagcagt acctggaaac tcagcaaaat tgagacttct agttcagcat   1680

gaaataaaca ctctaagagc ccaggaaaaa catggccttc aacctgctct gcttgtacat   1740

tgggcaaaat gccttcagaa aatgggcagc ggtcttaatt ctttttatga tcaacgagaa   1800

tacataggga gaagtgttca ttattggaag aaagttttgc cattgttgaa gataataaaa   1860

aagaagaaca gtattcctga acctattgat cctctgttta aacattttca tagtgtagac   1920

attcaggcat cagaaattgt tgaatatgaa gaagacgcac acgtaacttt tgctatattg   1980

gatgcagtaa atggaaatat agaagatgct atgactgctt ttgaatctat aaaaagtgtt   2040

gtttcttatt ggaatcttgc actgattttt cacaggaagg cagaagacat tgcaaatgat   2100

gccctttctc ctgaagaaca agaagaatgc aaaaattatc tgagaaagac caggggctac   2160

ctaataaaga ttttagatga cagtgattca aatctttcag tggtcaagaa attgcctgtg   2220

cccctggagt ctgtaaaaga gatgcttaag tcagtcatgc aggaactcga aaactatagt   2280

gaaggaggtc ctctctataa aaatggttct ttgcgaaatg cggattcaga aataaaacat   2340

tctacaccat ctcctaccaa atattcacta tcaccaagta aaagttacaa gtattctccc   2400

aaaacaccac ctcgatgggc agaagatcag aattctttac tgaaaatgat tcgccaagaa   2460

gtaaaggcca ttaaggaaga aatgcaggag ttgaaactaa atagcagtaa gtcagcatcc   2520

catcatcgtt ggcccacaga gaattatgga ccagactcgg tgcctgatgg atatcagggg   2580

tcacagacat ttcatggggc tccactaaca gttgcaacta ctggcccttc agtatattat   2640

agtcagtcac cagcatataa ttcccagtat cttctcagac cagcagctaa tgttactccc   2700

acaaagggtt cttctaatac agaatttaag tcaaccaaag aaggattttc catccctgtg   2760

tctgctgatg gatttaaatt tggcatttcg gaaccaggaa atcaagaaaa gaaaagtgaa   2820

aagcctcttg aaaatgatac tggcttacag gctcaggata ttagtggccg gaagaagggc   2880

cgtggtgtga tttttggcca aacaagtagc acttttacat ttgcagatgt tgcaaaatca   2940

acttcaggag aaggatttca gtttggcaaa aaagacctca atttcaaggg attttcaggt   3000

gctggagaaa aattattctc atcacaatac ggtaaaatgg ccaataaagc aaacacttcc   3060

ggtgactttg agaaagatga tgatgcctat aagactgagg acagcgatga catccatttt   3120

gaaccagtag ttcaaatgcc tgaaaaagta gaacttgtaa caggagaaga aggtgaaaaa   3180

gttctgtatt cacagggggt aaaactattt agatttgatg ctgaggtaag tcagtggaaa   3240

gaaaggggct tggggaactt aaaaattctc aaaaacgagg tcaatggcaa agtaagaatg   3300

ctgatgcaaa gagaacaagt actaaaagtg tgtgctaatc attggataac gactacaatg   3360

aacctgaagc ccctctctgg atcagataga gcatggatgt ggtcagccag tgatttctct   3420

gatggtgatg ccaaactaga gcgattggca gcaaaattta aaacaccaga gctggctgaa   3480

gaattcaagc agaaatttga ggaatgccag cggcttctgt tagacatacc acttcaaact   3540

ccccataaac ttgtagatac tggcagagct gccaagttaa tacagagagc tgaagaaatg   3600

aagagtggac tgaaagattt caaaacattt ttgacaaatg atcaaacaaa agtcgctgag   3660

gaagaaaata agggttcagg tacaggtgcg gccggtgcct cagacacaac aataaaaccc   3720

aatgctgaaa acactgggcc cacattagaa tgggataact atgatttaag ggaagatgct   3780

ttggatgata gtgtcagtag tagctcagta catgcttctc cattggcaag tagccctgtg   3840

agaaaaaatc ttttccactt tgatgagtca acaacaggat ctaacttcag ttttaaatct   3900

gctttgagtc tatctaagtc tcctgccaag ttgaatcaga gtgggacttc agttggcact   3960

gatgaagaat ctgatgttac tcaagaagaa gagagagatg gacagtactt tgaacctgtt   4020

gttcctttac ctgatctagt tgaagtatcc agtggtgagg aaaatgaaca agttgttttt   4080

agtcacaggg cagaattcta cagatatgat aaagatgttg gtcaatggaa agaaaggggc   4140

attggtgata taaagatttt acagaattat gataataagc acgttcgtat actgatgaga   4200

agggaccaag tattaaaact ttgtgccaat cacagaataa ctccagacat gagtttgcaa   4260

aatatgaaag ggacagaaag agtatgggtg tggactgcat gtgattttgc agatggagaa   4320

agaaaagtag agcatttagc tgttcgtttt aaactacagg atgttgcaga ctcgtttaag   4380

aaaatttttg atgaagcaaa aacagcccag gaaaaagatt ctttgataac acctcatgtt   4440

tctcggtcaa gcactcccag agagtcacca tgtggcaaaa ttgctgtagc tgtattagaa   4500

gaaaccacaa gagagaggac agatgttatt cagggtgatg atgtagcaga tgcagcttca   4560

gaagttgaag tgtctagcac atctgaaaca acaacaaaag cagtggtttc tcctccaaag   4620

tttgtatttg gttcagagtc tgttaaaaga atttttagta gtgaaaaatc aaaaccattt   4680

gcatttggca acagttctgc cactgggtct ttgtttggat ttagttttaa tgcacctttg   4740

aaaagtaaca atagtgaaac tagttcagta gcccagagtg gatctgaaag caaagtggaa   4800

cctaaaaaat gtgaactgtc aaagaactct gatatcgaac agtcttcaga tagcaaagtc   4860

aaaaatctct ctgcttcctt tccaacggaa gaatcttcaa tcaactacac atttaaaaca   4920

ccagaaaagg agcctccatt atggtatgct gaatttacta aagaagaatt ggttcagaag   4980

ctcagttcca ccacaaaaag tgcagatcac ttaaacggcc tgcttcggga aatagaggca   5040

accaatgcag tccttatgga gcaaattaag cttctcaaaa gtgaaataag aagattggaa   5100

aggaatcaag agcaagaggt gtctgcagct aacgtggaac acttgaagaa cgtcttgctg   5160

cagttcattt tcttgaagcc aggtagtgaa agagagagac ttcttcctgt tataaatacg   5220

atgttgcagc tcagccttga agaaaaggga aaacttgctg cggttgctca aggtcttcaa   5280

gaaacctcca tacccaagaa aaaatagaaa gcaacgatgt tctactatgg tgccaaaaat   5340

agttgaacat cgacatcaaa aagattcttt ctgtctgctt attcacatat tctggtttga   5400

attaaaagtg atgaaattat cctaaataca gttggccctc tgtatccatg ggttccacat   5460

ccacaaattc aaccaactgt ggatggaaaa gacttgaaaa agatgagaga aaataacaat   5520

atgacaataa aacataatac aaataaaaac aatacagcat aacaacgatt acatagcatt   5580

tacattatat tagggattgc acaagagaag gtatgtaggt tatatgcaaa tactgcacca   5640

ttttacataa gggacttgag aagcatggat tttggtagcc acaggggtcc tggaaccaat   5700

ccctcacaga cacagaggga caactttaca gtagatgaac acaaagatga aagggaaagt   5760

cttacctagg tctgcgggga gaagtggaac tccatttttg acaggtgatg ccattttttg   5820

ttttggacat cgtccctctg tagttctttc cattcccagt cttgcactct gaaagataca   5880

ctgaaggaaa gtccacacag cggtcaaagt ctttcacaag acaccacgtg aaggtctgca   5940

cagcatagtc acgttgagaa aaagatctca tgcaccagac cccctgtttc tgctttctaa   6000

aagatcatct tttgcatctg caaaaaggct gcagtaaact gggccattcc atactttgat   6060

tcatgtattc aaatgctact tatgagctct ctgtgtattg agccccacca ggatgctggg   6120

gacacacggg gcacagtgca gccagaggct tggccgtcat agagctcaca ttctagtgga   6180

atcaggcagg ggggttacag gaaatattca aggaaacaat ataaaatgag atcacttaat   6240

gatgatacat gttacataca tgatgagaca gagtaagaga atggggaaag ggtttttaga   6300

tgggggaatg gcaggctttt ccgaggctga aagagatcca acccacttct atttcttcag   6360

gctcccagtg atatgaaaaa gtgccaaaca gggctataaa attgtggtct actgtaaatg   6420

gtttgcagta aaagttctca accagcttcc actcaaccaa ctcaccagtt agacaatggg   6480

ccctctcctg tgtttaaaac agtctggtgc ccacctgggt ccacatgcag ctggcaggtg   6540

tttgctagtg tgcccaccca tgtctgttcc ccccacgtga gttatgtgct tacaacgagt   6600

catttctttg cattttccaa ctttcttaca tttatattta attaaagatg atctaaactg   6660

agaaatgaat gtgaaaagga acaaagctct tttttgtttg gtttttaact aaattaaatg   6720

tttttaacaa gttgaaacgt gaatcattta aaaaattgct atcagatcca cagagggcaa   6780

tccactcata tagttgactg taaagcttga ggaggaattc ataaaaatct aaaggtttta   6840

cacatgcaga ttgattaata aatgtcgaga tatggtccac ttcaaaaata aggaaagtaa   6900

ttattgtaga tgttgcacta gagcatagtt tatgcaggaa atgcaccaga gaccttctac   6960

tggtgacccc atattcgaag aaaaaaagcc tctgctctac atcaaaaggt gtcaagtaca   7020

cttgtgtttt caatgaaaat ataaaatgtt taaggtatat ttgcaccatc atttaaggtt   7080

acccacttta gccattttta aattcactga tcaatcacat ggggaaagta ctcctaacat   7140

acctgcagca aactaa                                                   7156


<210>  4412
<211>  1766
<212>  PRT
<213>  Homosapiens

<400>  4412

Met Ser Cys Ser Lys Ala Tyr Gly Glu Arg Tyr Val Ala Ser Val Gln 
1               5                   10                  15      


Gly Ser Ala Pro Ser Pro Arg Lys Lys Ser Thr Arg Gly Phe Tyr Phe 
            20                  25                  30          


Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 
        35                  40                  45              


Ile Cys Thr Tyr Ile Asn Val Arg Glu Met Asp Pro Arg Ala His Arg 
    50                  55                  60                  


Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Glu Lys Ala Val 
65                  70                  75                  80  


Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 
                85                  90                  95      


Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 
            100                 105                 110         


Arg Ala Glu Tyr Trp Val Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 
        115                 120                 125             


Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 
    130                 135                 140                 


Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 
145                 150                 155                 160 


Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Leu Tyr Arg 
                165                 170                 175     


Ser Thr Lys Arg Leu Lys Asp Ala Val Ala Arg Cys His Glu Ala Glu 
            180                 185                 190         


Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 
        195                 200                 205             


Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 
    210                 215                 220                 


Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 
225                 230                 235                 240 


Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg 
                245                 250                 255     


Glu Leu Leu Glu Ser Phe Asp Ser Ala Leu Gln Ser Ala Lys Ser Ser 
            260                 265                 270         


Leu Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly 
        275                 280                 285             


His Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His 
    290                 295                 300                 


Gly Asn Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys 
305                 310                 315                 320 


Tyr Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys 
                325                 330                 335     


Gly Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu 
            340                 345                 350         


Ser Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp 
        355                 360                 365             


Phe Leu Lys Val Val Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser 
    370                 375                 380                 


Ala Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser 
385                 390                 395                 400 


Phe Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Gln Glu Pro Glu 
                405                 410                 415     


Leu Glu Asp Leu Ala Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn 
            420                 425                 430         


Gly Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu 
        435                 440                 445             


Pro Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His 
    450                 455                 460                 


Leu Pro Gln Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile 
465                 470                 475                 480 


Cys Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser 
                485                 490                 495     


His Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln 
            500                 505                 510         


Pro Leu Cys Leu Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg 
        515                 520                 525             


Gln Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala 
    530                 535                 540                 


Val Pro Gly Asn Ser Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile 
545                 550                 555                 560 


Asn Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu 
                565                 570                 575     


Val His Trp Ala Lys Cys Leu Gln Lys Met Gly Ser Gly Leu Asn Ser 
            580                 585                 590         


Phe Tyr Asp Gln Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys 
        595                 600                 605             


Lys Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro 
    610                 615                 620                 


Glu Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln 
625                 630                 635                 640 


Ala Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Val Thr Phe Ala 
                645                 650                 655     


Ile Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Met Thr Ala Phe 
            660                 665                 670         


Glu Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe 
        675                 680                 685             


His Arg Lys Ala Glu Asp Ile Ala Asn Asp Ala Leu Ser Pro Glu Glu 
    690                 695                 700                 


Gln Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr Arg Gly Tyr Leu Ile 
705                 710                 715                 720 


Lys Ile Leu Asp Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu 
                725                 730                 735     


Pro Val Pro Leu Glu Ser Val Lys Glu Met Leu Lys Ser Val Met Gln 
            740                 745                 750         


Glu Leu Glu Asn Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser 
        755                 760                 765             


Leu Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr 
    770                 775                 780                 


Lys Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Lys Thr 
785                 790                 795                 800 


Pro Pro Arg Trp Ala Glu Asp Gln Asn Ser Leu Leu Lys Met Ile Arg 
                805                 810                 815     


Gln Glu Val Lys Ala Ile Lys Glu Glu Met Gln Glu Leu Lys Leu Asn 
            820                 825                 830         


Ser Ser Lys Ser Ala Ser His His Arg Trp Pro Thr Glu Asn Tyr Gly 
        835                 840                 845             


Pro Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly 
    850                 855                 860                 


Ala Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln 
865                 870                 875                 880 


Ser Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val 
                885                 890                 895     


Thr Pro Thr Lys Gly Ser Ser Asn Thr Glu Phe Lys Ser Thr Lys Glu 
            900                 905                 910         


Gly Phe Ser Ile Pro Val Ser Ala Asp Gly Phe Lys Phe Gly Ile Ser 
        915                 920                 925             


Glu Pro Gly Asn Gln Glu Lys Lys Ser Glu Lys Pro Leu Glu Asn Asp 
    930                 935                 940                 


Thr Gly Leu Gln Ala Gln Asp Ile Ser Gly Arg Lys Lys Gly Arg Gly 
945                 950                 955                 960 


Val Ile Phe Gly Gln Thr Ser Ser Thr Phe Thr Phe Ala Asp Val Ala 
                965                 970                 975     


Lys Ser Thr Ser Gly Glu Gly Phe Gln Phe Gly Lys Lys Asp Leu Asn 
            980                 985                 990         


Phe Lys Gly Phe Ser Gly Ala Gly  Glu Lys Leu Phe Ser  Ser Gln Tyr 
        995                 1000                 1005             


Gly Lys  Met Ala Asn Lys Ala  Asn Thr Ser Gly Asp  Phe Glu Lys 
    1010                 1015                 1020             


Asp Asp  Asp Ala Tyr Lys Thr  Glu Asp Ser Asp Asp  Ile His Phe 
    1025                 1030                 1035             


Glu Pro  Val Val Gln Met Pro  Glu Lys Val Glu Leu  Val Thr Gly 
    1040                 1045                 1050             


Glu Glu  Gly Glu Lys Val Leu  Tyr Ser Gln Gly Val  Lys Leu Phe 
    1055                 1060                 1065             


Arg Phe  Asp Ala Glu Val Ser  Gln Trp Lys Glu Arg  Gly Leu Gly 
    1070                 1075                 1080             


Asn Leu  Lys Ile Leu Lys Asn  Glu Val Asn Gly Lys  Val Arg Met 
    1085                 1090                 1095             


Leu Met  Gln Arg Glu Gln Val  Leu Lys Val Cys Ala  Asn His Trp 
    1100                 1105                 1110             


Ile Thr  Thr Thr Met Asn Leu  Lys Pro Leu Ser Gly  Ser Asp Arg 
    1115                 1120                 1125             


Ala Trp  Met Trp Ser Ala Ser  Asp Phe Ser Asp Gly  Asp Ala Lys 
    1130                 1135                 1140             


Leu Glu  Arg Leu Ala Ala Lys  Phe Lys Thr Pro Glu  Leu Ala Glu 
    1145                 1150                 1155             


Glu Phe  Lys Gln Lys Phe Glu  Glu Cys Gln Arg Leu  Leu Leu Asp 
    1160                 1165                 1170             


Ile Pro  Leu Gln Thr Pro His  Lys Leu Val Asp Thr  Gly Arg Ala 
    1175                 1180                 1185             


Ala Lys  Leu Ile Gln Arg Ala  Glu Glu Met Lys Ser  Gly Leu Lys 
    1190                 1195                 1200             


Asp Phe  Lys Thr Phe Leu Thr  Asn Asp Gln Thr Lys  Val Ala Glu 
    1205                 1210                 1215             


Glu Glu  Asn Lys Gly Ser Gly  Thr Gly Ala Ala Gly  Ala Ser Asp 
    1220                 1225                 1230             


Thr Thr  Ile Lys Pro Asn Ala  Glu Asn Thr Gly Pro  Thr Leu Glu 
    1235                 1240                 1245             


Trp Asp  Asn Tyr Asp Leu Arg  Glu Asp Ala Leu Asp  Asp Ser Val 
    1250                 1255                 1260             


Ser Ser  Ser Ser Val His Ala  Ser Pro Leu Ala Ser  Ser Pro Val 
    1265                 1270                 1275             


Arg Lys  Asn Leu Phe His Phe  Asp Glu Ser Thr Thr  Gly Ser Asn 
    1280                 1285                 1290             


Phe Ser  Phe Lys Ser Ala Leu  Ser Leu Ser Lys Ser  Pro Ala Lys 
    1295                 1300                 1305             


Leu Asn  Gln Ser Gly Thr Ser  Val Gly Thr Asp Glu  Glu Ser Asp 
    1310                 1315                 1320             


Val Thr  Gln Glu Glu Glu Arg  Asp Gly Gln Tyr Phe  Glu Pro Val 
    1325                 1330                 1335             


Val Pro  Leu Pro Asp Leu Val  Glu Val Ser Ser Gly  Glu Glu Asn 
    1340                 1345                 1350             


Glu Gln  Val Val Phe Ser His  Arg Ala Glu Phe Tyr  Arg Tyr Asp 
    1355                 1360                 1365             


Lys Asp  Val Gly Gln Trp Lys  Glu Arg Gly Ile Gly  Asp Ile Lys 
    1370                 1375                 1380             


Ile Leu  Gln Asn Tyr Asp Asn  Lys His Val Arg Ile  Leu Met Arg 
    1385                 1390                 1395             


Arg Asp  Gln Val Leu Lys Leu  Cys Ala Asn His Arg  Ile Thr Pro 
    1400                 1405                 1410             


Asp Met  Ser Leu Gln Asn Met  Lys Gly Thr Glu Arg  Val Trp Val 
    1415                 1420                 1425             


Trp Thr  Ala Cys Asp Phe Ala  Asp Gly Glu Arg Lys  Val Glu His 
    1430                 1435                 1440             


Leu Ala  Val Arg Phe Lys Leu  Gln Asp Val Ala Asp  Ser Phe Lys 
    1445                 1450                 1455             


Lys Ile  Phe Asp Glu Ala Lys  Thr Ala Gln Glu Lys  Asp Ser Leu 
    1460                 1465                 1470             


Ile Thr  Pro His Val Ser Arg  Ser Ser Thr Pro Arg  Glu Ser Pro 
    1475                 1480                 1485             


Cys Gly  Lys Ile Ala Val Ala  Val Leu Glu Glu Thr  Thr Arg Glu 
    1490                 1495                 1500             


Arg Thr  Asp Val Ile Gln Gly  Asp Asp Val Ala Asp  Ala Ala Ser 
    1505                 1510                 1515             


Glu Val  Glu Val Ser Ser Thr  Ser Glu Thr Thr Thr  Lys Ala Val 
    1520                 1525                 1530             


Val Ser  Pro Pro Lys Phe Val  Phe Gly Ser Glu Ser  Val Lys Arg 
    1535                 1540                 1545             


Ile Phe  Ser Ser Glu Lys Ser  Lys Pro Phe Ala Phe  Gly Asn Ser 
    1550                 1555                 1560             


Ser Ala  Thr Gly Ser Leu Phe  Gly Phe Ser Phe Asn  Ala Pro Leu 
    1565                 1570                 1575             


Lys Ser  Asn Asn Ser Glu Thr  Ser Ser Val Ala Gln  Ser Gly Ser 
    1580                 1585                 1590             


Glu Ser  Lys Val Glu Pro Lys  Lys Cys Glu Leu Ser  Lys Asn Ser 
    1595                 1600                 1605             


Asp Ile  Glu Gln Ser Ser Asp  Ser Lys Val Lys Asn  Leu Ser Ala 
    1610                 1615                 1620             


Ser Phe  Pro Thr Glu Glu Ser  Ser Ile Asn Tyr Thr  Phe Lys Thr 
    1625                 1630                 1635             


Pro Glu  Lys Glu Pro Pro Leu  Trp Tyr Ala Glu Phe  Thr Lys Glu 
    1640                 1645                 1650             


Glu Leu  Val Gln Lys Leu Ser  Ser Thr Thr Lys Ser  Ala Asp His 
    1655                 1660                 1665             


Leu Asn  Gly Leu Leu Arg Glu  Ile Glu Ala Thr Asn  Ala Val Leu 
    1670                 1675                 1680             


Met Glu  Gln Ile Lys Leu Leu  Lys Ser Glu Ile Arg  Arg Leu Glu 
    1685                 1690                 1695             


Arg Asn  Gln Glu Gln Glu Val  Ser Ala Ala Asn Val  Glu His Leu 
    1700                 1705                 1710             


Lys Asn  Val Leu Leu Gln Phe  Ile Phe Leu Lys Pro  Gly Ser Glu 
    1715                 1720                 1725             


Arg Glu  Arg Leu Leu Pro Val  Ile Asn Thr Met Leu  Gln Leu Ser 
    1730                 1735                 1740             


Leu Glu  Glu Lys Gly Lys Leu  Ala Ala Val Ala Gln  Gly Leu Gln 
    1745                 1750                 1755             


Glu Thr  Ser Ile Pro Lys Lys  Lys 
    1760                 1765     


<210>  4413
<211>  7138
<212>  DNA
<213>  Homosapiens

<400>  4413
ggcgcgatga gttgcagcaa ggcctacggg gagcggtacg tcgcctcggt gcagggctcc     60

gccccgtcgc ctcgaaagaa gtcaacgaga ggattctatt ttgcaaagct gtattatgaa    120

gctaaagaat atgatcttgc taaaaaatac atatgtactt acattaatgt gcgagagatg    180

gatcccagag ctcacagatt tctgggtctt ctttatgaat tggaagaaaa cacagagaaa    240

gccgttgaat gttacaggcg ttcagtggaa ttaaacccaa cacaaaaaga tcttgtgttg    300

aagattgcag aattgctttg taaaaatgat gttactgatg gaagagcaga atactgggtg    360

gaaagagcag caaaactttt cccaggaagt cctgcaattt ataaactaaa ggaacagctt    420

ctagattgtg aaggtgaaga tggatggaat aaactttttg acttgattca gtcagaactt    480

tatgtaagac ctgatgacgt ccatgtgaac atccggctag tggagttgta tcgctcaact    540

aaaagattga aggatgctgt ggcccgctgc catgaggcag agaggaacat agctttgcgt    600

tcaagtttag agtggaattc gtgtgttgta cagaccctta aggaatatct ggagtcttta    660

cagtgtttgg agtctgataa aagtgactgg cgagcaacca atacagactt actgctggcc    720

tatgctaatc ttatgcttct tacgctttcc actagagatg tgcaggaaag tagagaatta    780

ctggaaagtt ttgatagtgc tcttcagtct gcgaaatctt ctttgggtgg aaatgatgaa    840

ctgtcagcta ctttcttaga aatgaaagga catttctaca tgcatgctgg ttctctgctc    900

ttgaagatgg gtcagcatgg taataatgtt caatggcgag ctctttctga gctggctgca    960

ttgtgctatc tcatagcatt tcaggttcca agaccaaaga ttaaattaat aaaaggtgaa   1020

gctggacaaa atctgctgga aatgatggcc tgtgaccgac tgagccaatc agggcacatg   1080

ttgctaaact taagtcgtgg caagcaagat tttttaaaag tggttgttga aacttttgcc   1140

aacaaaagcg ggcagtctgc attatatgat gctctgtttt ctagtcagtc acctaaggat   1200

acatcttttc ttggtagcga tgatattgga aacattgatg tacaagaacc agagcttgaa   1260

gatttggcta gatacgatgt tggtgctatt cgagcacata atggtagtct tcagcacctt   1320

acttggcttg gcttacagtg gaattcattg cctgctttac ctggaatccg aaaatggcta   1380

aaacagcttt tccatcattt gccccaggaa acctcaaggc ttgaaacaaa tgcacctgaa   1440

tcaatatgta ttttagatct tgaagtattt ctccttggag tagtatatac cagccactta   1500

caattaaagg agaaatgtaa ttctcaccac agctcctatc agccgttatg cctgcccctt   1560

cctgtgtgta aacagctttg tacagaaaga caaaaatctt ggtgggatgc ggtttgtact   1620

ctgattcaca gaaaagcagt acctggaaac tcagcaaaat tgagacttct agttcagcat   1680

gaaataaaca ctctaagagc ccaggaaaaa catggccttc aacctgctct gcttgtacat   1740

tgggcaaaat gccttcagaa aatgggcagc ggtcttaatt ctttttatga tcaacgagaa   1800

tacataggga gaagtgttca ttattggaag aaagttttgc cattgttgaa gataataaaa   1860

aagaagaaca gtattcctga acctattgat cctctgttta aacattttca tagtgtagac   1920

attcaggcat cagaaattgt tgaatatgaa gaagacgcac acgtaacttt tgctatattg   1980

gatgcagtaa atggaaatat agaagatgct atgactgctt ttgaatctat aaaaagtgtt   2040

gtttcttatt ggaatcttgc actgattttt cacaggaagg cagaagacat tgcaaatgat   2100

gccctttctc ctgaagaaca agaagaatgc aaaaattatc tgagaaagac caggggctac   2160

ctaataaaga ttttagatga cagtgattca aatctttcag tggtcaagaa attgcctgtg   2220

cccctggagt ctgtaaaaga gatgcttaag tcagtcatgc aggaactcga aaactatagt   2280

gaaggaggtc ctctctataa aaatggttct ttgcgaaatg cggattcaga aataaaacat   2340

tctacaccat ctcctaccaa atattcacta tcaccaagta aaagttacaa gtattctccc   2400

aaaacaccac ctcgatgggc agaagatcag aattctttac tgaaaatgat tcgccaagaa   2460

gtaaaggcca ttatgaaact aaatagcagt aagtcagcat cccatcatcg ttggcccaca   2520

gagaattatg gaccagactc ggtgcctgat ggatatcagg ggtcacagac atttcatggg   2580

gctccactaa cagttgcaac tactggccct tcagtatatt atagtcagtc accagcatat   2640

aattcccagt atcttctcag accagcagct aatgttactc ccacaaaggg ttcttctaat   2700

acagaattta agtcaaccaa agaaggattt tccatccctg tgtctgctga tggatttaaa   2760

tttggcattt cggaaccagg aaatcaagaa aagaaaagtg aaaagcctct tgaaaatgat   2820

actggcttac aggctcagga tattagtggc cggaagaagg gccgtggtgt gatttttggc   2880

caaacaagta gcacttttac atttgcagat gttgcaaaat caacttcagg agaaggattt   2940

cagtttggca aaaaagacct caatttcaag ggattttcag gtgctggaga aaaattattc   3000

tcatcacaat acggtaaaat ggccaataaa gcaaacactt ccggtgactt tgagaaagat   3060

gatgatgcct ataagactga ggacagcgat gacatccatt ttgaaccagt agttcaaatg   3120

cctgaaaaag tagaacttgt aacaggagaa gaaggtgaaa aagttctgta ttcacagggg   3180

gtaaaactat ttagatttga tgctgaggta agtcagtgga aagaaagggg cttggggaac   3240

ttaaaaattc tcaaaaacga ggtcaatggc aaagtaagaa tgctgatgca aagagaacaa   3300

gtactaaaag tgtgtgctaa tcattggata acgactacaa tgaacctgaa gcccctctct   3360

ggatcagata gagcatggat gtggtcagcc agtgatttct ctgatggtga tgccaaacta   3420

gagcgattgg cagcaaaatt taaaacacca gagctggctg aagaattcaa gcagaaattt   3480

gaggaatgcc agcggcttct gttagacata ccacttcaaa ctccccataa acttgtagat   3540

actggcagag ctgccaagtt aatacagaga gctgaagaaa tgaagagtgg actgaaagat   3600

ttcaaaacat ttttgacaaa tgatcaaaca aaagtcgctg aggaagaaaa taagggttca   3660

ggtacaggtg cggccggtgc ctcagacaca acaataaaac ccaatgctga aaacactggg   3720

cccacattag aatgggataa ctatgattta agggaagatg ctttggatga tagtgtcagt   3780

agtagctcag tacatgcttc tccattggca agtagccctg tgagaaaaaa tcttttccac   3840

tttgatgagt caacaacagg atctaacttc agttttaaat ctgctttgag tctatctaag   3900

tctcctgcca agttgaatca gagtgggact tcagttggca ctgatgaaga atctgatgtt   3960

actcaagaag aagagagaga tggacagtac tttgaacctg ttgttccttt acctgatcta   4020

gttgaagtat ccagtggtga ggaaaatgaa caagttgttt ttagtcacag ggcagaattc   4080

tacagatatg ataaagatgt tggtcaatgg aaagaaaggg gcattggtga tataaagatt   4140

ttacagaatt atgataataa gcacgttcgt atactgatga gaagggacca agtattaaaa   4200

ctttgtgcca atcacagaat aactccagac atgagtttgc aaaatatgaa agggacagaa   4260

agagtatggg tgtggactgc atgtgatttt gcagatggag aaagaaaagt agagcattta   4320

gctgttcgtt ttaaactaca ggatgttgca gactcgttta agaaaatttt tgatgaagca   4380

aaaacagccc aggaaaaaga ttctttgata acacctcatg tttctcggtc aagcactccc   4440

agagagtcac catgtggcaa aattgctgta gctgtattag aagaaaccac aagagagagg   4500

acagatgtta ttcagggtga tgatgtagca gatgcagctt cagaagttga agtgtctagc   4560

acatctgaaa caacaacaaa agcagtggtt tctcctccaa agtttgtatt tggttcagag   4620

tctgttaaaa gaatttttag tagtgaaaaa tcaaaaccat ttgcatttgg caacagttct   4680

gccactgggt ctttgtttgg atttagtttt aatgcacctt tgaaaagtaa caatagtgaa   4740

actagttcag tagcccagag tggatctgaa agcaaagtgg aacctaaaaa atgtgaactg   4800

tcaaagaact ctgatatcga acagtcttca gatagcaaag tcaaaaatct ctctgcttcc   4860

tttccaacgg aagaatcttc aatcaactac acatttaaaa caccagaaaa ggagcctcca   4920

ttatggtatg ctgaatttac taaagaagaa ttggttcaga agctcagttc caccacaaaa   4980

agtgcagatc acttaaacgg cctgcttcgg gaaatagagg caaccaatgc agtccttatg   5040

gagcaaatta agcttctcaa aagtgaaata agaagattgg aaaggaatca agagcaagag   5100

gtgtctgcag ctaacgtgga acacttgaag aacgtcttgc tgcagttcat tttcttgaag   5160

ccaggtagtg aaagagagag acttcttcct gttataaata cgatgttgca gctcagcctt   5220

gaagaaaagg gaaaacttgc tgcggttgct caaggtcttc aagaaacctc catacccaag   5280

aaaaaataga aagcaacgat gttctactat ggtgccaaaa atagttgaac atcgacatca   5340

aaaagattct ttctgtctgc ttattcacat attctggttt gaattaaaag tgatgaaatt   5400

atcctaaata cagttggccc tctgtatcca tgggttccac atccacaaat tcaaccaact   5460

gtggatggaa aagacttgaa aaagatgaga gaaaataaca atatgacaat aaaacataat   5520

acaaataaaa acaatacagc ataacaacga ttacatagca tttacattat attagggatt   5580

gcacaagaga aggtatgtag gttatatgca aatactgcac cattttacat aagggacttg   5640

agaagcatgg attttggtag ccacaggggt cctggaacca atccctcaca gacacagagg   5700

gacaacttta cagtagatga acacaaagat gaaagggaaa gtcttaccta ggtctgcggg   5760

gagaagtgga actccatttt tgacaggtga tgccattttt tgttttggac atcgtccctc   5820

tgtagttctt tccattccca gtcttgcact ctgaaagata cactgaagga aagtccacac   5880

agcggtcaaa gtctttcaca agacaccacg tgaaggtctg cacagcatag tcacgttgag   5940

aaaaagatct catgcaccag accccctgtt tctgctttct aaaagatcat cttttgcatc   6000

tgcaaaaagg ctgcagtaaa ctgggccatt ccatactttg attcatgtat tcaaatgcta   6060

cttatgagct ctctgtgtat tgagccccac caggatgctg gggacacacg gggcacagtg   6120

cagccagagg cttggccgtc atagagctca cattctagtg gaatcaggca ggggggttac   6180

aggaaatatt caaggaaaca atataaaatg agatcactta atgatgatac atgttacata   6240

catgatgaga cagagtaaga gaatggggaa agggttttta gatgggggaa tggcaggctt   6300

ttccgaggct gaaagagatc caacccactt ctatttcttc aggctcccag tgatatgaaa   6360

aagtgccaaa cagggctata aaattgtggt ctactgtaaa tggtttgcag taaaagttct   6420

caaccagctt ccactcaacc aactcaccag ttagacaatg ggccctctcc tgtgtttaaa   6480

acagtctggt gcccacctgg gtccacatgc agctggcagg tgtttgctag tgtgcccacc   6540

catgtctgtt ccccccacgt gagttatgtg cttacaacga gtcatttctt tgcattttcc   6600

aactttctta catttatatt taattaaaga tgatctaaac tgagaaatga atgtgaaaag   6660

gaacaaagct cttttttgtt tggtttttaa ctaaattaaa tgtttttaac aagttgaaac   6720

gtgaatcatt taaaaaattg ctatcagatc cacagagggc aatccactca tatagttgac   6780

tgtaaagctt gaggaggaat tcataaaaat ctaaaggttt tacacatgca gattgattaa   6840

taaatgtcga gatatggtcc acttcaaaaa taaggaaagt aattattgta gatgttgcac   6900

tagagcatag tttatgcagg aaatgcacca gagaccttct actggtgacc ccatattcga   6960

agaaaaaaag cctctgctct acatcaaaag gtgtcaagta cacttgtgtt ttcaatgaaa   7020

atataaaatg tttaaggtat atttgcacca tcatttaagg ttacccactt tagccatttt   7080

taaattcact gatcaatcac atggggaaag tactcctaac atacctgcag caaactaa     7138


<210>  4414
<211>  1760
<212>  PRT
<213>  Homosapiens

<400>  4414

Met Ser Cys Ser Lys Ala Tyr Gly Glu Arg Tyr Val Ala Ser Val Gln 
1               5                   10                  15      


Gly Ser Ala Pro Ser Pro Arg Lys Lys Ser Thr Arg Gly Phe Tyr Phe 
            20                  25                  30          


Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 
        35                  40                  45              


Ile Cys Thr Tyr Ile Asn Val Arg Glu Met Asp Pro Arg Ala His Arg 
    50                  55                  60                  


Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Glu Lys Ala Val 
65                  70                  75                  80  


Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 
                85                  90                  95      


Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 
            100                 105                 110         


Arg Ala Glu Tyr Trp Val Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 
        115                 120                 125             


Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 
    130                 135                 140                 


Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 
145                 150                 155                 160 


Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Leu Tyr Arg 
                165                 170                 175     


Ser Thr Lys Arg Leu Lys Asp Ala Val Ala Arg Cys His Glu Ala Glu 
            180                 185                 190         


Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 
        195                 200                 205             


Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 
    210                 215                 220                 


Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 
225                 230                 235                 240 


Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg 
                245                 250                 255     


Glu Leu Leu Glu Ser Phe Asp Ser Ala Leu Gln Ser Ala Lys Ser Ser 
            260                 265                 270         


Leu Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly 
        275                 280                 285             


His Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His 
    290                 295                 300                 


Gly Asn Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys 
305                 310                 315                 320 


Tyr Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys 
                325                 330                 335     


Gly Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu 
            340                 345                 350         


Ser Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp 
        355                 360                 365             


Phe Leu Lys Val Val Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser 
    370                 375                 380                 


Ala Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser 
385                 390                 395                 400 


Phe Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Gln Glu Pro Glu 
                405                 410                 415     


Leu Glu Asp Leu Ala Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn 
            420                 425                 430         


Gly Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu 
        435                 440                 445             


Pro Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His 
    450                 455                 460                 


Leu Pro Gln Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile 
465                 470                 475                 480 


Cys Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser 
                485                 490                 495     


His Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln 
            500                 505                 510         


Pro Leu Cys Leu Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg 
        515                 520                 525             


Gln Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala 
    530                 535                 540                 


Val Pro Gly Asn Ser Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile 
545                 550                 555                 560 


Asn Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu 
                565                 570                 575     


Val His Trp Ala Lys Cys Leu Gln Lys Met Gly Ser Gly Leu Asn Ser 
            580                 585                 590         


Phe Tyr Asp Gln Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys 
        595                 600                 605             


Lys Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro 
    610                 615                 620                 


Glu Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln 
625                 630                 635                 640 


Ala Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Val Thr Phe Ala 
                645                 650                 655     


Ile Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Met Thr Ala Phe 
            660                 665                 670         


Glu Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe 
        675                 680                 685             


His Arg Lys Ala Glu Asp Ile Ala Asn Asp Ala Leu Ser Pro Glu Glu 
    690                 695                 700                 


Gln Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr Arg Gly Tyr Leu Ile 
705                 710                 715                 720 


Lys Ile Leu Asp Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu 
                725                 730                 735     


Pro Val Pro Leu Glu Ser Val Lys Glu Met Leu Lys Ser Val Met Gln 
            740                 745                 750         


Glu Leu Glu Asn Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser 
        755                 760                 765             


Leu Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr 
    770                 775                 780                 


Lys Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Lys Thr 
785                 790                 795                 800 


Pro Pro Arg Trp Ala Glu Asp Gln Asn Ser Leu Leu Lys Met Ile Arg 
                805                 810                 815     


Gln Glu Val Lys Ala Ile Met Lys Leu Asn Ser Ser Lys Ser Ala Ser 
            820                 825                 830         


His His Arg Trp Pro Thr Glu Asn Tyr Gly Pro Asp Ser Val Pro Asp 
        835                 840                 845             


Gly Tyr Gln Gly Ser Gln Thr Phe His Gly Ala Pro Leu Thr Val Ala 
    850                 855                 860                 


Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln Ser Pro Ala Tyr Asn Ser 
865                 870                 875                 880 


Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val Thr Pro Thr Lys Gly Ser 
                885                 890                 895     


Ser Asn Thr Glu Phe Lys Ser Thr Lys Glu Gly Phe Ser Ile Pro Val 
            900                 905                 910         


Ser Ala Asp Gly Phe Lys Phe Gly Ile Ser Glu Pro Gly Asn Gln Glu 
        915                 920                 925             


Lys Lys Ser Glu Lys Pro Leu Glu Asn Asp Thr Gly Leu Gln Ala Gln 
    930                 935                 940                 


Asp Ile Ser Gly Arg Lys Lys Gly Arg Gly Val Ile Phe Gly Gln Thr 
945                 950                 955                 960 


Ser Ser Thr Phe Thr Phe Ala Asp Val Ala Lys Ser Thr Ser Gly Glu 
                965                 970                 975     


Gly Phe Gln Phe Gly Lys Lys Asp Leu Asn Phe Lys Gly Phe Ser Gly 
            980                 985                 990         


Ala Gly Glu Lys Leu Phe Ser Ser  Gln Tyr Gly Lys Met  Ala Asn Lys 
        995                 1000                 1005             


Ala Asn  Thr Ser Gly Asp Phe  Glu Lys Asp Asp Asp  Ala Tyr Lys 
    1010                 1015                 1020             


Thr Glu  Asp Ser Asp Asp Ile  His Phe Glu Pro Val  Val Gln Met 
    1025                 1030                 1035             


Pro Glu  Lys Val Glu Leu Val  Thr Gly Glu Glu Gly  Glu Lys Val 
    1040                 1045                 1050             


Leu Tyr  Ser Gln Gly Val Lys  Leu Phe Arg Phe Asp  Ala Glu Val 
    1055                 1060                 1065             


Ser Gln  Trp Lys Glu Arg Gly  Leu Gly Asn Leu Lys  Ile Leu Lys 
    1070                 1075                 1080             


Asn Glu  Val Asn Gly Lys Val  Arg Met Leu Met Gln  Arg Glu Gln 
    1085                 1090                 1095             


Val Leu  Lys Val Cys Ala Asn  His Trp Ile Thr Thr  Thr Met Asn 
    1100                 1105                 1110             


Leu Lys  Pro Leu Ser Gly Ser  Asp Arg Ala Trp Met  Trp Ser Ala 
    1115                 1120                 1125             


Ser Asp  Phe Ser Asp Gly Asp  Ala Lys Leu Glu Arg  Leu Ala Ala 
    1130                 1135                 1140             


Lys Phe  Lys Thr Pro Glu Leu  Ala Glu Glu Phe Lys  Gln Lys Phe 
    1145                 1150                 1155             


Glu Glu  Cys Gln Arg Leu Leu  Leu Asp Ile Pro Leu  Gln Thr Pro 
    1160                 1165                 1170             


His Lys  Leu Val Asp Thr Gly  Arg Ala Ala Lys Leu  Ile Gln Arg 
    1175                 1180                 1185             


Ala Glu  Glu Met Lys Ser Gly  Leu Lys Asp Phe Lys  Thr Phe Leu 
    1190                 1195                 1200             


Thr Asn  Asp Gln Thr Lys Val  Ala Glu Glu Glu Asn  Lys Gly Ser 
    1205                 1210                 1215             


Gly Thr  Gly Ala Ala Gly Ala  Ser Asp Thr Thr Ile  Lys Pro Asn 
    1220                 1225                 1230             


Ala Glu  Asn Thr Gly Pro Thr  Leu Glu Trp Asp Asn  Tyr Asp Leu 
    1235                 1240                 1245             


Arg Glu  Asp Ala Leu Asp Asp  Ser Val Ser Ser Ser  Ser Val His 
    1250                 1255                 1260             


Ala Ser  Pro Leu Ala Ser Ser  Pro Val Arg Lys Asn  Leu Phe His 
    1265                 1270                 1275             


Phe Asp  Glu Ser Thr Thr Gly  Ser Asn Phe Ser Phe  Lys Ser Ala 
    1280                 1285                 1290             


Leu Ser  Leu Ser Lys Ser Pro  Ala Lys Leu Asn Gln  Ser Gly Thr 
    1295                 1300                 1305             


Ser Val  Gly Thr Asp Glu Glu  Ser Asp Val Thr Gln  Glu Glu Glu 
    1310                 1315                 1320             


Arg Asp  Gly Gln Tyr Phe Glu  Pro Val Val Pro Leu  Pro Asp Leu 
    1325                 1330                 1335             


Val Glu  Val Ser Ser Gly Glu  Glu Asn Glu Gln Val  Val Phe Ser 
    1340                 1345                 1350             


His Arg  Ala Glu Phe Tyr Arg  Tyr Asp Lys Asp Val  Gly Gln Trp 
    1355                 1360                 1365             


Lys Glu  Arg Gly Ile Gly Asp  Ile Lys Ile Leu Gln  Asn Tyr Asp 
    1370                 1375                 1380             


Asn Lys  His Val Arg Ile Leu  Met Arg Arg Asp Gln  Val Leu Lys 
    1385                 1390                 1395             


Leu Cys  Ala Asn His Arg Ile  Thr Pro Asp Met Ser  Leu Gln Asn 
    1400                 1405                 1410             


Met Lys  Gly Thr Glu Arg Val  Trp Val Trp Thr Ala  Cys Asp Phe 
    1415                 1420                 1425             


Ala Asp  Gly Glu Arg Lys Val  Glu His Leu Ala Val  Arg Phe Lys 
    1430                 1435                 1440             


Leu Gln  Asp Val Ala Asp Ser  Phe Lys Lys Ile Phe  Asp Glu Ala 
    1445                 1450                 1455             


Lys Thr  Ala Gln Glu Lys Asp  Ser Leu Ile Thr Pro  His Val Ser 
    1460                 1465                 1470             


Arg Ser  Ser Thr Pro Arg Glu  Ser Pro Cys Gly Lys  Ile Ala Val 
    1475                 1480                 1485             


Ala Val  Leu Glu Glu Thr Thr  Arg Glu Arg Thr Asp  Val Ile Gln 
    1490                 1495                 1500             


Gly Asp  Asp Val Ala Asp Ala  Ala Ser Glu Val Glu  Val Ser Ser 
    1505                 1510                 1515             


Thr Ser  Glu Thr Thr Thr Lys  Ala Val Val Ser Pro  Pro Lys Phe 
    1520                 1525                 1530             


Val Phe  Gly Ser Glu Ser Val  Lys Arg Ile Phe Ser  Ser Glu Lys 
    1535                 1540                 1545             


Ser Lys  Pro Phe Ala Phe Gly  Asn Ser Ser Ala Thr  Gly Ser Leu 
    1550                 1555                 1560             


Phe Gly  Phe Ser Phe Asn Ala  Pro Leu Lys Ser Asn  Asn Ser Glu 
    1565                 1570                 1575             


Thr Ser  Ser Val Ala Gln Ser  Gly Ser Glu Ser Lys  Val Glu Pro 
    1580                 1585                 1590             


Lys Lys  Cys Glu Leu Ser Lys  Asn Ser Asp Ile Glu  Gln Ser Ser 
    1595                 1600                 1605             


Asp Ser  Lys Val Lys Asn Leu  Ser Ala Ser Phe Pro  Thr Glu Glu 
    1610                 1615                 1620             


Ser Ser  Ile Asn Tyr Thr Phe  Lys Thr Pro Glu Lys  Glu Pro Pro 
    1625                 1630                 1635             


Leu Trp  Tyr Ala Glu Phe Thr  Lys Glu Glu Leu Val  Gln Lys Leu 
    1640                 1645                 1650             


Ser Ser  Thr Thr Lys Ser Ala  Asp His Leu Asn Gly  Leu Leu Arg 
    1655                 1660                 1665             


Glu Ile  Glu Ala Thr Asn Ala  Val Leu Met Glu Gln  Ile Lys Leu 
    1670                 1675                 1680             


Leu Lys  Ser Glu Ile Arg Arg  Leu Glu Arg Asn Gln  Glu Gln Glu 
    1685                 1690                 1695             


Val Ser  Ala Ala Asn Val Glu  His Leu Lys Asn Val  Leu Leu Gln 
    1700                 1705                 1710             


Phe Ile  Phe Leu Lys Pro Gly  Ser Glu Arg Glu Arg  Leu Leu Pro 
    1715                 1720                 1725             


Val Ile  Asn Thr Met Leu Gln  Leu Ser Leu Glu Glu  Lys Gly Lys 
    1730                 1735                 1740             


Leu Ala  Ala Val Ala Gln Gly  Leu Gln Glu Thr Ser  Ile Pro Lys 
    1745                 1750                 1755             


Lys Lys  
    1760 


<210>  4415
<211>  6691
<212>  DNA
<213>  Homosapiens

<400>  4415
cagatacata tgtacttaca ttaatgtgcg agagatggat cccagagctc acagatttct     60

gggtcttctt tatgaattgg aagaaaacac agagaaagcc gttgaatgtt acaggcgttc    120

agtggaatta aacccaacac aaaaagatct tgtgttgaag attgcagaat tgctttgtaa    180

aaatgatgtt actgatggaa gagcagaata ctgggtggaa agagcagcaa aacttttccc    240

aggaagtcct gcaatttata aactaaagga acagcttcta gattgtgaag gtgaagatgg    300

atggaataaa ctttttgact tgattcagtc agaactttat gtaagacctg atgacgtcca    360

tgtgaacatc cggctagtgg agttgtatcg ctcaactaaa agattgaagg atgctgtggc    420

ccgctgccat gaggcagaga ggaacatagc tttgcgttca agtttagagt ggaattcgtg    480

tgttgtacag acccttaagt tttgatagtg ctcttcagtc tgcgaaatct tctttgggtg    540

gaaatgatga actgtcagct actttcttag aaatgaaagg acatttctac atgcatgctg    600

gttctctgct cttgaagatg ggtcagcatg gtaataatgt tcaatggcga gctctttctg    660

agctggctgc attgtgctat ctcatagcat ttcaggttcc aagaccaaag attaaattaa    720

taaaaggtga agctggacaa aatctgctgg aaatgatggc ctgtgaccga ctgagccaat    780

cagcgatgat attggaaaca ttgatgtaca agaaccagag cttgaagatt tggctagata    840

cgatgttggt gctattcgag cacataatgg tagtcttcag caccttactt ggcttggctt    900

acagtggaat tcattgcctg ctttacctgg aatccgaaaa tggctaaaac agcttttcca    960

tcatttgccc caggaaacct caaggcttga aacaaatgca cctgaatcaa tatgtatttt   1020

agatcttgaa gtatttctcc ttggagtagt atataccagc cacttacaat taaaggagaa   1080

atgtaattct caccacagct cctatcagcc gttatgcctg ccccttcctg tgtgtaaaca   1140

gctttgtaca gaaagacaaa aatcttggtg ggatgcggtt tgtactctga ttcacagaaa   1200

agcagttaaa ttgaactatt ttttagacct ggaaactcag caaaattgag acttctagtt   1260

cagcatgaaa taaacactct aagagcccag gaaaaacatg gccttcaacc tgctctgctt   1320

gtacattggg caaaatgcct tcagaaaatg ggcagcggtc ttaattcttt ttatgatcaa   1380

cgagaataca tagggagaag tgttcattat tggaagaaag ttttgccatt gttgaagata   1440

ataaaaaaga agaacagtat tcctgaacct attgatcctc tgtttaaaca ttttcatagt   1500

gtagacattc aggcatcaga aattgttgaa tatgaagaag acgcacacgt aacttttgct   1560

atattggatg cagtaaatgg aaatatagaa gatgctatga ctgcttttga atctataaaa   1620

agtgttgttt cttattggaa tcttgcactg atttttcaca ggaaggcaga agacattgca   1680

aatgatgccc tttctcctga agaacaagaa gaatgcaaaa attatctgag aaagaccagg   1740

ggctacctaa taaagatttt agatgacagt gattcaaatc tttcagtggt caagaaattg   1800

cctgtgcccc tggagtctgt aaaagagatg cttaagtcag tcatgcagga actcgaaaac   1860

tatagtgaag gaggtcctct ctataaaaat ggttctttgc gaaatgcgga ttcagaaata   1920

aaacattcta caccatctcc taccaaatat tcactatcac caagtaaaag ttacaagtat   1980

tctcccaaaa caccacctcg atgggcagaa gatcagaatt ctttactgaa aatgattcgc   2040

caagaagtaa aggccattaa ggaagaaatg caggagttga aactaaatag cagtaagtca   2100

gcatcccatc atcgttggcc cacagagaat tatggaccag actcggtgcc tgatggatat   2160

caggggtcac agacatttca tggggctcca ctaacagttg caactactgg cccttcagta   2220

tattatagtc agtcaccagc atataattcc cagtatcttc tcagaccagc agctaatgtt   2280

actcccacaa agggttcttc taatacagaa tttaagtcaa ccaaagaagg attttccatc   2340

cctgtgtctg ctgatggatt taaatttggc atttcggaac caggaaatca agaaaagaaa   2400

agtgaaaagc ctcttgaaaa tgatactggc ttacaggctc aggatattag tggccggaag   2460

aagggccgtg gtgtgatttt tggccaaaca agtagcactt ttacatttgc agatgttgca   2520

aaatcaactt caggagaagg atttcagttt ggcaaaaaag acctcaattt caagggattt   2580

tcaggtgctg gagaaaaatt attctcatca caatacggta aaatggccaa taaagcaaac   2640

acttccggtg actttgagaa agatgatgat gcctataaga ctgaggacag cgatgacatc   2700

cattttgaac cagtagttca aatgcctgaa aaagtagaac ttgtaacagg agaagaaggt   2760

gaaaaagttc tgtattcaca gggggtaaaa ctatttagat ttgatgctga ggtaagtcag   2820

tggaaagaaa ggggcttggg gaacttaaaa attctcaaaa acgaggtcaa tggcaaagta   2880

agaatgctga tgcaaagaga acaagtacta aaagtgtgtg ctaatcattg gataacgact   2940

acaatgaacc tgaagcccct ctctggatca gatagagcat ggatgtggtc agccagtgat   3000

ttctctgatg gtgatgccaa actagagcga ttggcagcaa aatttaaaac accagagctg   3060

gctgaagaat tcaagcagaa atttgaggaa tgccagcggc ttctgttaga cataccactt   3120

caaactcccc ataaacttgt agatactggc agagctgcca agttaataca gagagctgaa   3180

gaaatgaaga gtggactgaa agatttcaaa acatttttga caaatgatca aacaaaagtc   3240

gctgaggaag aaaataaggg ttcaggtaca ggtgcggccg gtgcctcaga cacaacaata   3300

aaacccaatg ctgaaaacac tgggcccaca ttagaatggg ataactatga tttaagggaa   3360

gatgctttgg atgatagtgt cagtagtagc tcagtacatg cttctccatt ggcaagtagc   3420

cctgtgagaa aaaatctttt ccactttgat gagtcaacaa caggatctaa cttcagtttt   3480

aaatctgctt tgagtctatc taagtctcct gccaagttga atcagagtgg gacttcagtt   3540

ggcactgatg aagaatctga tgttactcaa gaagaagaga gagatggaca gtactttgaa   3600

cctgttgttc ctttacctga tctagttgaa gtatccagtg gtgaggaaaa tgaacaagtt   3660

gtttttagtc acagggcaga attctacaga tatgataaag atgttggtca atggaaagaa   3720

aggggcattg gtgatataaa gattttacag aattatgata ataagcacgt tcgtatactg   3780

atgagaaggg accaagtatt aaaactttgt gccaatcaca gaataactcc agacatgagt   3840

ttgcaaaata tgaaagggac agaaagagta tgggtgtgga ctgcatgtga ttttgcagat   3900

ggagaaagaa aagtagagca tttagctgtt cgttttaaac tacaggatgt tgcagactcg   3960

tttaagaaaa tttttgatga agcaaaaaca gcccaggaaa aagattcttt gataacacct   4020

catgtttctc ggtcaagcac tcccagagag tcaccatgtg gcaaaattgc tgtagctgta   4080

ttagaagaaa ccacaagaga gaggacagat gttattcagg gtgatgatgt agcagatgca   4140

gcttcagaag ttgaagtgtc tagcacatct gaaacaacaa caaaagcagt ggtttctcct   4200

ccaaagtttg tatttggttc agagtctgtt aaaagaattt ttagtagtga aaaatcaaaa   4260

ccatttgcat ttggcaacag ttctgccact gggtctttgt ttggatttag ttttaatgca   4320

cctttgaaaa gtaacaatag tgaaactagt tcagtagccc agagtggatc tgaaagcaaa   4380

gtggaaccta aaaaatgtga actgtcaaag aactctgata tcgaacagtc ttcagatagc   4440

aaagtcaaaa atctctctgc ttcctttcca acggaagaat cttcaatcaa ctacacattt   4500

aaaacaccag aaaaggagcc tccattatgg tatgctgaat ttactaaaga agaattggtt   4560

cagaagctca gttccaccac aaaaagtgca gatcacttaa acggcctgct tcgggaaata   4620

gaggcaacca atgcagtcct tatggagcaa attaagcttc tcaaaagtga aataagaaga   4680

ttggaaagga atcaagagca agaggtgtct gcagctaacg tggaacactt gaagaacgtc   4740

ttgctgcagt tcattttctt gaagccaggt agtgaaagag agagacttct tcctgttata   4800

aatacgatgt tgcagctcag ccttgaagaa aagggaaaac ttgctgcggt tgctcaaggt   4860

gaggaataaa atgcttcccg ttcttctgga tgggcatcct atcttcgtag ttggtttgga   4920

cttcgatagg ttgatggaag gaatgttttt attaaccaaa taaaatctat ttacaaaaat   4980

ggttcatgtg tattaccatc attcttttgt caaaaagtgt gtatatgttt gcatttacat   5040

atatttgtac atctatatga cagatgtatt ttaaaagttt caacttgaag taaaagtaca   5100

acagcttgaa gtgttgatac caggccacag ccctctaact catgtgatct cccatgcatg   5160

ctgccagaat aaaaccacca ggaatgaatt cactccccac ttctctggaa cctcaggacc   5220

cgcccatttc tcggcagtac tgtgaatttt gaagttaaac taaattttgg taccatacca   5280

actggaattt aggctttaaa aataatgttt caaggccagg tgtggtgatt catgcctgaa   5340

atcccactac ttggggaggc tgaggctgga gaatcgtttg aggctagtga gctgtgattg   5400

tatcactgca ctccagctcg gggaacagag cgagaccttg tctctaaaaa taataatagt   5460

aataaaaata acattttatg actatttatt gcaaggtcag atttacagat tgttataaat   5520

tgttgagaaa tttttgtgat tagaatatga aggaaaaagc tttgttggta aaagtgacat   5580

gttaaggggc tatgaagtaa atatgctgca gttaattgtg ctaagttaaa atacagttta   5640

gttatttgct ttaaaataaa ctcttctttt tttctttaaa gtatactatc tcaaaactca   5700

ttatgttgtc agagccctag agctggctag tgtaacactg actatgaata ggtgggccca   5760

ccacttgagt tgaggtgatt tcatggtgtc tttccaggct cttgataggg tgtcactgca   5820

tgcaagccat gaatctgttt tgagaatcct ctccattttc ccaaataaaa acctatccca   5880

acagtgacta tatcactcag cattgaatct aaatataaaa gtggtgcttt cagtgttttt   5940

ggcagatagt gttccataag ctttccatca gaagggattt tagacacctt agaggtccgt   6000

gctacatctt cacagttcct ctgaataacc ttaggtggta gtgttacttg cctttgacac   6060

cgctgcatat gttttaatga ctagatccaa actgtgttgt tcttaaatca aaaattggat   6120

aatttttaat atttatgtat taatcacata gtatgctctc tgaagttctc ttaagccttc   6180

agtttatact cttaattttc tttctgagct ggggaactga ctttgcactt tggttacaca   6240

gaacattggt ttccaattta gtttaactga aatttgctgc tgatatgttg agtttgttct   6300

ttaaaaaata tctcatatat ctcgtctttc ctccttagaa gaacagacct aactagcgaa   6360

tgtatgaatg aaaatgcatc tatttcagag ccgacatgaa gagtttagtt tttttacttt   6420

ataaactgtg aatatgagta tgccagctgc atacgatgta actaatcata tttaaatata   6480

tttcactttc tctttgactt gagacctttt gaagtctgta taaacttgtt ttgaaatata   6540

gtctccactt acaaatgtca taacaaaata cttttttgca tgataaaaaa ttgattacaa   6600

aaggcatatt ctttcatggt ttctgcaatg agaggaagtg taatgattat tttaatattt   6660

ctattaaata tgtttaactg tatattttta t                                  6691


<210>  4416
<211>  1173
<212>  PRT
<213>  Homosapiens

<400>  4416

Met Gly Ser Gly Leu Asn Ser Phe Tyr Asp Gln Arg Glu Tyr Ile Gly 
1               5                   10                  15      


Arg Ser Val His Tyr Trp Lys Lys Val Leu Pro Leu Leu Lys Ile Ile 
            20                  25                  30          


Lys Lys Lys Asn Ser Ile Pro Glu Pro Ile Asp Pro Leu Phe Lys His 
        35                  40                  45              


Phe His Ser Val Asp Ile Gln Ala Ser Glu Ile Val Glu Tyr Glu Glu 
    50                  55                  60                  


Asp Ala His Val Thr Phe Ala Ile Leu Asp Ala Val Asn Gly Asn Ile 
65                  70                  75                  80  


Glu Asp Ala Met Thr Ala Phe Glu Ser Ile Lys Ser Val Val Ser Tyr 
                85                  90                  95      


Trp Asn Leu Ala Leu Ile Phe His Arg Lys Ala Glu Asp Ile Ala Asn 
            100                 105                 110         


Asp Ala Leu Ser Pro Glu Glu Gln Glu Glu Cys Lys Asn Tyr Leu Arg 
        115                 120                 125             


Lys Thr Arg Gly Tyr Leu Ile Lys Ile Leu Asp Asp Ser Asp Ser Asn 
    130                 135                 140                 


Leu Ser Val Val Lys Lys Leu Pro Val Pro Leu Glu Ser Val Lys Glu 
145                 150                 155                 160 


Met Leu Lys Ser Val Met Gln Glu Leu Glu Asn Tyr Ser Glu Gly Gly 
                165                 170                 175     


Pro Leu Tyr Lys Asn Gly Ser Leu Arg Asn Ala Asp Ser Glu Ile Lys 
            180                 185                 190         


His Ser Thr Pro Ser Pro Thr Lys Tyr Ser Leu Ser Pro Ser Lys Ser 
        195                 200                 205             


Tyr Lys Tyr Ser Pro Lys Thr Pro Pro Arg Trp Ala Glu Asp Gln Asn 
    210                 215                 220                 


Ser Leu Leu Lys Met Ile Arg Gln Glu Val Lys Ala Ile Lys Glu Glu 
225                 230                 235                 240 


Met Gln Glu Leu Lys Leu Asn Ser Ser Lys Ser Ala Ser His His Arg 
                245                 250                 255     


Trp Pro Thr Glu Asn Tyr Gly Pro Asp Ser Val Pro Asp Gly Tyr Gln 
            260                 265                 270         


Gly Ser Gln Thr Phe His Gly Ala Pro Leu Thr Val Ala Thr Thr Gly 
        275                 280                 285             


Pro Ser Val Tyr Tyr Ser Gln Ser Pro Ala Tyr Asn Ser Gln Tyr Leu 
    290                 295                 300                 


Leu Arg Pro Ala Ala Asn Val Thr Pro Thr Lys Gly Ser Ser Asn Thr 
305                 310                 315                 320 


Glu Phe Lys Ser Thr Lys Glu Gly Phe Ser Ile Pro Val Ser Ala Asp 
                325                 330                 335     


Gly Phe Lys Phe Gly Ile Ser Glu Pro Gly Asn Gln Glu Lys Lys Ser 
            340                 345                 350         


Glu Lys Pro Leu Glu Asn Asp Thr Gly Leu Gln Ala Gln Asp Ile Ser 
        355                 360                 365             


Gly Arg Lys Lys Gly Arg Gly Val Ile Phe Gly Gln Thr Ser Ser Thr 
    370                 375                 380                 


Phe Thr Phe Ala Asp Val Ala Lys Ser Thr Ser Gly Glu Gly Phe Gln 
385                 390                 395                 400 


Phe Gly Lys Lys Asp Leu Asn Phe Lys Gly Phe Ser Gly Ala Gly Glu 
                405                 410                 415     


Lys Leu Phe Ser Ser Gln Tyr Gly Lys Met Ala Asn Lys Ala Asn Thr 
            420                 425                 430         


Ser Gly Asp Phe Glu Lys Asp Asp Asp Ala Tyr Lys Thr Glu Asp Ser 
        435                 440                 445             


Asp Asp Ile His Phe Glu Pro Val Val Gln Met Pro Glu Lys Val Glu 
    450                 455                 460                 


Leu Val Thr Gly Glu Glu Gly Glu Lys Val Leu Tyr Ser Gln Gly Val 
465                 470                 475                 480 


Lys Leu Phe Arg Phe Asp Ala Glu Val Ser Gln Trp Lys Glu Arg Gly 
                485                 490                 495     


Leu Gly Asn Leu Lys Ile Leu Lys Asn Glu Val Asn Gly Lys Val Arg 
            500                 505                 510         


Met Leu Met Gln Arg Glu Gln Val Leu Lys Val Cys Ala Asn His Trp 
        515                 520                 525             


Ile Thr Thr Thr Met Asn Leu Lys Pro Leu Ser Gly Ser Asp Arg Ala 
    530                 535                 540                 


Trp Met Trp Ser Ala Ser Asp Phe Ser Asp Gly Asp Ala Lys Leu Glu 
545                 550                 555                 560 


Arg Leu Ala Ala Lys Phe Lys Thr Pro Glu Leu Ala Glu Glu Phe Lys 
                565                 570                 575     


Gln Lys Phe Glu Glu Cys Gln Arg Leu Leu Leu Asp Ile Pro Leu Gln 
            580                 585                 590         


Thr Pro His Lys Leu Val Asp Thr Gly Arg Ala Ala Lys Leu Ile Gln 
        595                 600                 605             


Arg Ala Glu Glu Met Lys Ser Gly Leu Lys Asp Phe Lys Thr Phe Leu 
    610                 615                 620                 


Thr Asn Asp Gln Thr Lys Val Ala Glu Glu Glu Asn Lys Gly Ser Gly 
625                 630                 635                 640 


Thr Gly Ala Ala Gly Ala Ser Asp Thr Thr Ile Lys Pro Asn Ala Glu 
                645                 650                 655     


Asn Thr Gly Pro Thr Leu Glu Trp Asp Asn Tyr Asp Leu Arg Glu Asp 
            660                 665                 670         


Ala Leu Asp Asp Ser Val Ser Ser Ser Ser Val His Ala Ser Pro Leu 
        675                 680                 685             


Ala Ser Ser Pro Val Arg Lys Asn Leu Phe His Phe Asp Glu Ser Thr 
    690                 695                 700                 


Thr Gly Ser Asn Phe Ser Phe Lys Ser Ala Leu Ser Leu Ser Lys Ser 
705                 710                 715                 720 


Pro Ala Lys Leu Asn Gln Ser Gly Thr Ser Val Gly Thr Asp Glu Glu 
                725                 730                 735     


Ser Asp Val Thr Gln Glu Glu Glu Arg Asp Gly Gln Tyr Phe Glu Pro 
            740                 745                 750         


Val Val Pro Leu Pro Asp Leu Val Glu Val Ser Ser Gly Glu Glu Asn 
        755                 760                 765             


Glu Gln Val Val Phe Ser His Arg Ala Glu Phe Tyr Arg Tyr Asp Lys 
    770                 775                 780                 


Asp Val Gly Gln Trp Lys Glu Arg Gly Ile Gly Asp Ile Lys Ile Leu 
785                 790                 795                 800 


Gln Asn Tyr Asp Asn Lys His Val Arg Ile Leu Met Arg Arg Asp Gln 
                805                 810                 815     


Val Leu Lys Leu Cys Ala Asn His Arg Ile Thr Pro Asp Met Ser Leu 
            820                 825                 830         


Gln Asn Met Lys Gly Thr Glu Arg Val Trp Val Trp Thr Ala Cys Asp 
        835                 840                 845             


Phe Ala Asp Gly Glu Arg Lys Val Glu His Leu Ala Val Arg Phe Lys 
    850                 855                 860                 


Leu Gln Asp Val Ala Asp Ser Phe Lys Lys Ile Phe Asp Glu Ala Lys 
865                 870                 875                 880 


Thr Ala Gln Glu Lys Asp Ser Leu Ile Thr Pro His Val Ser Arg Ser 
                885                 890                 895     


Ser Thr Pro Arg Glu Ser Pro Cys Gly Lys Ile Ala Val Ala Val Leu 
            900                 905                 910         


Glu Glu Thr Thr Arg Glu Arg Thr Asp Val Ile Gln Gly Asp Asp Val 
        915                 920                 925             


Ala Asp Ala Ala Ser Glu Val Glu Val Ser Ser Thr Ser Glu Thr Thr 
    930                 935                 940                 


Thr Lys Ala Val Val Ser Pro Pro Lys Phe Val Phe Gly Ser Glu Ser 
945                 950                 955                 960 


Val Lys Arg Ile Phe Ser Ser Glu Lys Ser Lys Pro Phe Ala Phe Gly 
                965                 970                 975     


Asn Ser Ser Ala Thr Gly Ser Leu Phe Gly Phe Ser Phe Asn Ala Pro 
            980                 985                 990         


Leu Lys Ser Asn Asn Ser Glu Thr  Ser Ser Val Ala Gln  Ser Gly Ser 
        995                 1000                 1005             


Glu Ser  Lys Val Glu Pro Lys  Lys Cys Glu Leu Ser  Lys Asn Ser 
    1010                 1015                 1020             


Asp Ile  Glu Gln Ser Ser Asp  Ser Lys Val Lys Asn  Leu Ser Ala 
    1025                 1030                 1035             


Ser Phe  Pro Thr Glu Glu Ser  Ser Ile Asn Tyr Thr  Phe Lys Thr 
    1040                 1045                 1050             


Pro Glu  Lys Glu Pro Pro Leu  Trp Tyr Ala Glu Phe  Thr Lys Glu 
    1055                 1060                 1065             


Glu Leu  Val Gln Lys Leu Ser  Ser Thr Thr Lys Ser  Ala Asp His 
    1070                 1075                 1080             


Leu Asn  Gly Leu Leu Arg Glu  Ile Glu Ala Thr Asn  Ala Val Leu 
    1085                 1090                 1095             


Met Glu  Gln Ile Lys Leu Leu  Lys Ser Glu Ile Arg  Arg Leu Glu 
    1100                 1105                 1110             


Arg Asn  Gln Glu Gln Glu Val  Ser Ala Ala Asn Val  Glu His Leu 
    1115                 1120                 1125             


Lys Asn  Val Leu Leu Gln Phe  Ile Phe Leu Lys Pro  Gly Ser Glu 
    1130                 1135                 1140             


Arg Glu  Arg Leu Leu Pro Val  Ile Asn Thr Met Leu  Gln Leu Ser 
    1145                 1150                 1155             


Leu Glu  Glu Lys Gly Lys Leu  Ala Ala Val Ala Gln  Gly Glu Glu 
    1160                 1165                 1170             


<210>  4417
<211>  498
<212>  DNA
<213>  Homosapiens

<400>  4417
atgacgaact tctatgaaga aaggacaacg atgattgcag ccagggattt gcaggaattt     60

gttccttttg gtggagacca ctgcaagcac caccctaatg ctttgaacct tcaacttcgc    120

cagctgcagc cagcttcaga attatggtct tctgatggtg ctgctggctt ggtgggatcc    180

cttcaggagg ttacaatcca cgagaaacag aaggaaaact ggcagttaag gaaaggagta    240

agtgaaattg gagaagatgt ggactatgat gaggaactct atgttgctgg aaatatggtg    300

atatggagca aaggaagtaa aagccaggca ttggcagttt ataaagcatt tacagttgac    360

agtcctgttc agcaggaccc tctaatggcc tctaagtttt caaatgaagg gaagaatcac    420

aagtttctca ctttacatca aaaactagaa atgattaagc ttcgtgagga aggcgtgttg    480

aaagctgaga taggttga                                                  498


<210>  4418
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  4418

Met Thr Asn Phe Tyr Glu Glu Arg Thr Thr Met Ile Ala Ala Arg Asp 
1               5                   10                  15      


Leu Gln Glu Phe Val Pro Phe Gly Gly Asp His Cys Lys His His Pro 
            20                  25                  30          


Asn Ala Leu Asn Leu Gln Leu Arg Gln Leu Gln Pro Ala Ser Glu Leu 
        35                  40                  45              


Trp Ser Ser Asp Gly Ala Ala Gly Leu Val Gly Ser Leu Gln Glu Val 
    50                  55                  60                  


Thr Ile His Glu Lys Gln Lys Glu Asn Trp Gln Leu Arg Lys Gly Val 
65                  70                  75                  80  


Ser Glu Ile Gly Glu Asp Val Asp Tyr Asp Glu Glu Leu Tyr Val Ala 
                85                  90                  95      


Gly Asn Met Val Ile Trp Ser Lys Gly Ser Lys Ser Gln Ala Leu Ala 
            100                 105                 110         


Val Tyr Lys Ala Phe Thr Val Asp Ser Pro Val Gln Gln Asp Pro Leu 
        115                 120                 125             


Met Ala Ser Lys Phe Ser Asn Glu Gly Lys Asn His Lys Phe Leu Thr 
    130                 135                 140                 


Leu His Gln Lys Leu Glu Met Ile Lys Leu Arg Glu Glu Gly Val Leu 
145                 150                 155                 160 


Lys Ala Glu Ile Gly 
                165 


<210>  4419
<211>  1028
<212>  DNA
<213>  Homosapiens

<400>  4419
catgccttgg aaccatgctg cttgaggctc tggactgcat cctaccacca actcgtccaa     60

ctgacaagcc cttgcacctg cctctccagg atgtctacaa aattggtggt attggtagtg    120

ttcctgttgg ccgagtggag actggtgttc tcaaacctgg tatggtggtc acctttgctc    180

cagtcaacgt tacaacagaa gtaaaatctg tcgaaatgca ccatgaagct ttgagtgaag    240

ctcttcctgg ggacaatgtg ggcttcaatg tcaagaatgt gtctgtcaag gatgttcgtc    300

atggcaacgt tgctggtgac agcaaaaatg acccaccaat ggaagcagct ggtttcactg    360

ctcaggtgat tatcctgaac catccaggcc aaataagcac tggctatgcc cctgtattgg    420

attgccacac ggctcatatt gcatgcaagt ttgctgagct gaaggaaaag attgatcacc    480

gttctggtaa aaagctggaa gatggcccta aattcttgaa gtctgttgat gctgccattg    540

ttgatatggt tcctggcaag cccatgtgtg ttgagagctt ctcggactat ccatctttgg    600

gttgctttgc tgttcgtgat atgagacaga tagttacagt gggtgtcatc aaagcagtgg    660

acaagaagac tgctggagct ggcaaggtca ccaagtctgc ccagaaagct cagaaggcta    720

aatgaatatt atccctaata cctgccaccc cactcttaat cagtgatgga agaacagtct    780

cagaactctg tttcaattgg ccatttaagt ttagtagtaa aagactggtt aatgataaca    840

atgcatcgta aaaccttcag aaggaaagga gaatgttctg tggaccactt tggttttctt    900

ttttgcgtgt ggcagtttta agttactagc ttttaaaatc agcccttttt aatggaaaca    960

acttgaccaa aaatttgtca cagaattttg agacccattt aaaaagttta atgaggaaaa   1020

aaaaggtt                                                            1028


<210>  4420
<211>  236
<212>  PRT
<213>  Homosapiens

<400>  4420

Met Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg Pro Thr 
1               5                   10                  15      


Asp Lys Pro Leu His Leu Pro Leu Gln Asp Val Tyr Lys Ile Gly Gly 
            20                  25                  30          


Ile Gly Ser Val Pro Val Gly Arg Val Glu Thr Gly Val Leu Lys Pro 
        35                  40                  45              


Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu Val Lys 
    50                  55                  60                  


Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro Gly Asp 
65                  70                  75                  80  


Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Val Arg His 
                85                  90                  95      


Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu Ala Ala 
            100                 105                 110         


Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln Ile Ser 
        115                 120                 125             


Thr Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile Ala Cys 
    130                 135                 140                 


Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp His Arg Ser Gly Lys Lys 
145                 150                 155                 160 


Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Val Asp Ala Ala Ile Val 
                165                 170                 175     


Asp Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser Asp Tyr 
            180                 185                 190         


Pro Ser Leu Gly Cys Phe Ala Val Arg Asp Met Arg Gln Ile Val Thr 
        195                 200                 205             


Val Gly Val Ile Lys Ala Val Asp Lys Lys Thr Ala Gly Ala Gly Lys 
    210                 215                 220                 


Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Lys 
225                 230                 235     


<210>  4421
<211>  1366
<212>  DNA
<213>  Homosapiens

<400>  4421
gctttttttt tcacaatggg tttgccgcca gaacacaggt gtcatgaaaa ctacccccaa     60

aagccaaaat gggaaaggaa aagactcata ccaacattgt cgtcattgga cacatagatt    120

cgggcaagtc caccactact ggccatctga tctacaaagg cggtggcatc gacaaaagaa    180

ccattgaaaa atttgagaag gaggctgctg agatgggaaa gggctccttc aagtatgcct    240

gggtcttgga taaactgaaa gctgagtgtg aacatggtat caccattgat acctccttgt    300

ggaaatttga gaccagcaag tactatgtga ctatcgttga tgccccagga cacagagact    360

tcatcaaaaa catgattaca gagacatctc aggctgactg tgctgtcctg attgttgctg    420

ctggtgttgg tgaatttgaa gctggtatct ccaagaatgg gcaaacccaa gagcatgccc    480

ttctggctta cacactgggt gtgaaacaac taattgttgg tgttaacaaa atggattcta    540

ctgagccacc ctacagccag aagagatatg aggaaaattg ttaaggaagt cagcacttac    600

attaagaaaa ttggctacaa ccctgacaca gtagcatttg tgccaatttc tggttggaat    660

gtggagactg gtgttctcaa acctggtatg gtggtcacct ttgctccagt caacgttaca    720

acagaagtaa aatctgtcga aatgcaccat gaagctttga gtgaagctct tcctggggac    780

aatgtgggct tcaatgtcaa gaatgtgtct gtcaaggatg ttcgtcatgg caacgttgct    840

ggtgacagca aaaatgaccc accaatggaa gcagctggtt tcactgctca ggtgattatc    900

ctgaaccatc caggccaaat aagcactggc tatgcccctg tattggattg ccacacggct    960

catattgcat gcaagtttgc tgagctgaag gaaaagattg atcaccgttc tggtaaaaag   1020

ctggaagatg gccctaaatt cttgaagtct gttgatgctg ccattgttga tatggttcct   1080

ggcaagccca tgtgtgttga gagcttctcg gactatccat ctttgggttg ctttgctgtt   1140

cgtgatatga gacagatagt tacagtgggt gtcatcaaag cagtggacaa gaagactgct   1200

ggagctggca aggtcaccaa gtctgcccag aaagctcaga aggctaaatg aatattatcc   1260

ctaatacctg ccaccccact cttaatcagt gatggaagaa cagtctcaga actctgtttc   1320

aattggccat ttaagtttag taaatgttct gtggaccact ttggtt                  1366


<210>  4422
<211>  227
<212>  PRT
<213>  Homosapiens

<400>  4422

Met Arg Lys Ile Val Lys Glu Val Ser Thr Tyr Ile Lys Lys Ile Gly 
1               5                   10                  15      


Tyr Asn Pro Asp Thr Val Ala Phe Val Pro Ile Ser Gly Trp Asn Val 
            20                  25                  30          


Glu Thr Gly Val Leu Lys Pro Gly Met Val Val Thr Phe Ala Pro Val 
        35                  40                  45              


Asn Val Thr Thr Glu Val Lys Ser Val Glu Met His His Glu Ala Leu 
    50                  55                  60                  


Ser Glu Ala Leu Pro Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val 
65                  70                  75                  80  


Ser Val Lys Asp Val Arg His Gly Asn Val Ala Gly Asp Ser Lys Asn 
                85                  90                  95      


Asp Pro Pro Met Glu Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu 
            100                 105                 110         


Asn His Pro Gly Gln Ile Ser Thr Gly Tyr Ala Pro Val Leu Asp Cys 
        115                 120                 125             


His Thr Ala His Ile Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile 
    130                 135                 140                 


Asp His Arg Ser Gly Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys 
145                 150                 155                 160 


Ser Val Asp Ala Ala Ile Val Asp Met Val Pro Gly Lys Pro Met Cys 
                165                 170                 175     


Val Glu Ser Phe Ser Asp Tyr Pro Ser Leu Gly Cys Phe Ala Val Arg 
            180                 185                 190         


Asp Met Arg Gln Ile Val Thr Val Gly Val Ile Lys Ala Val Asp Lys 
        195                 200                 205             


Lys Thr Ala Gly Ala Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln 
    210                 215                 220                 


Lys Ala Lys 
225         


<210>  4423
<211>  1550
<212>  DNA
<213>  Homosapiens

<400>  4423
gctttttttt tcacaatggg tttgccgcca gaacacaggt gtcatgaaaa ctacccccaa     60

aagccaaaat gggaaaggaa aagactcata ccaacattgt cgtcattgga cacatagatt    120

cgggcaagtc caccactact ggccatctga tctacaaagg cggtggcatc gacaaaagaa    180

ccattgaaaa atttgagaag gaggctgctg agatgggaaa gggctccttc aagtatgcct    240

gggtcttgga taaactgaaa gctgagtgtg aacatggtat caccattgat acctccttgt    300

ggaaatttga gaccagcaag tactatgtga ctatcgttga tgccccagga cacagagact    360

tcatcaaaaa catgattaca gagacatctc aggctgactg tgctgtcctg attgttgctg    420

ctggtgttgg tgaatttgaa gctggtatct ccaagaatgg gcaaacccaa gagcatgccc    480

ttctggctta cacactgggt gtgaaacaac taattgttgg tgttaacaaa atggattcta    540

ctgagccacc ctacagccag aagagatatg aggaaaattg ttaaggaagt cagcacttac    600

attaagaaaa ttggctacaa ccctgacaca gtagcatttg tgccaatttc tggttggaat    660

gtggagactg gtgttctcaa acctggtatg gtggtcacct ttgctccagt caacgttaca    720

acagaagtaa aatctgtcga aatgcaccat gaagctttga gtgaagctct tcctggggac    780

aatgtgggct tcaatgtcaa gaatgtgtct gtcaaggatg ttcgtcatgg caacgttgct    840

ggtgacagca aaaatgaccc accaatggaa gcagctggtt tcactgctca ggtgattatc    900

ctgaaccatc caggccaaat aagcactggc tatgcccctg tattggattg ccacacggct    960

catattgcat gcaagtttgc tgagctgaag gaaaagattg atcaccgttc tggtaaaaag   1020

ctggaagatg gccctaaatt cttgaagtct gttgatgctg ccattgttga tatggttcct   1080

ggcaagccca tgtgtgttga gagcttctcg gactatccat ctttgggttg ctttgctgtt   1140

cgtgatatga gacagatagt tacagtgggt gtcatcaaag cagtggacaa gaagactgct   1200

ggagctggca aggtcaccaa gtctgcccag aaagctcaga aggctaaatg aatattatcc   1260

ctaatacctg ccaccccact cttaatcagt gatggaagaa cagtctcaga actctgtttc   1320

aattggccat ttaagtttag tagtaaaaga ctggttaatg ataacaatgc atcgtaaaac   1380

cttcagaagg aaaggagaat gttctgtgga ccactttggt tttctttttt gcgtgtggca   1440

gttttaagtt actagctttt aaaatcagcc ctttttaatg gaaacaactt gaccaaaaat   1500

ttgtcacaga attttgagac ccatttaaaa aattacatgc agaaaacagc              1550


<210>  4424
<211>  227
<212>  PRT
<213>  Homosapiens

<400>  4424

Met Arg Lys Ile Val Lys Glu Val Ser Thr Tyr Ile Lys Lys Ile Gly 
1               5                   10                  15      


Tyr Asn Pro Asp Thr Val Ala Phe Val Pro Ile Ser Gly Trp Asn Val 
            20                  25                  30          


Glu Thr Gly Val Leu Lys Pro Gly Met Val Val Thr Phe Ala Pro Val 
        35                  40                  45              


Asn Val Thr Thr Glu Val Lys Ser Val Glu Met His His Glu Ala Leu 
    50                  55                  60                  


Ser Glu Ala Leu Pro Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val 
65                  70                  75                  80  


Ser Val Lys Asp Val Arg His Gly Asn Val Ala Gly Asp Ser Lys Asn 
                85                  90                  95      


Asp Pro Pro Met Glu Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu 
            100                 105                 110         


Asn His Pro Gly Gln Ile Ser Thr Gly Tyr Ala Pro Val Leu Asp Cys 
        115                 120                 125             


His Thr Ala His Ile Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile 
    130                 135                 140                 


Asp His Arg Ser Gly Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys 
145                 150                 155                 160 


Ser Val Asp Ala Ala Ile Val Asp Met Val Pro Gly Lys Pro Met Cys 
                165                 170                 175     


Val Glu Ser Phe Ser Asp Tyr Pro Ser Leu Gly Cys Phe Ala Val Arg 
            180                 185                 190         


Asp Met Arg Gln Ile Val Thr Val Gly Val Ile Lys Ala Val Asp Lys 
        195                 200                 205             


Lys Thr Ala Gly Ala Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln 
    210                 215                 220                 


Lys Ala Lys 
225         


<210>  4425
<211>  1554
<212>  DNA
<213>  Homosapiens

<400>  4425
gctttttttt tcacaatggg tttgccgcca gaacacaggt gtcatgaaaa ctacccccaa     60

aagccaaaat gggaaaggaa aagactcata ccaacattgt cgtcattgga cacatagatt    120

cgggcaagtc caccactact ggccatctga tctacaaagg cggtggcatc gacaaaagaa    180

ccattgaaaa atttgagaag gaggctgctg agatgggaaa gggctccttc aagtatgcct    240

gggtcttgga taaactgaaa gctgagtgtg aacatggtat caccattgat acctccttgt    300

ggaaatttga gaccagcaag tactatgtga ctatcgttga tgccccagga cacagagact    360

tcatcaaaaa catgattaca gagacatctc aggctgactg tgctgtcctg attgttgctg    420

ctggtgttgg tgaatttgaa gctggtatct ccaagaatgg gcaaacccaa gagcatgccc    480

ttctggctta cacactgggt gtgaaacaac taattgttgg tgttaacaaa atggattcta    540

ctgagccacc ctacagccag aagagatatg aggaaaattg ttaaggaagt cagcacttac    600

attaagaaaa ttggctacaa ccctgacaca gtagcatttg tgccaatttc tggttggaat    660

gtggagactg gtgttctcaa acctggtatg gtggtcacct ttgctccagt caacgttaca    720

acagaagtaa aatctgtcga aatgcaccat gaagctttga gtgaagctct tcctggggac    780

aatgtgggct tcaatgtcaa gaatgtgtct gtcaaggatg ttcgtcatgg caacgttgct    840

ggtgacagca aaaatgaccc accaatggaa gcagctggtt tcactgctca ggtgattatc    900

ctgaaccatc caggccaaat aagcactggc tatgcccctg tattggattg ccacacggct    960

catattgcat gcaagtttgc tgagctgaag gaaaagattg atcaccgttc tggtaaaaag   1020

ctggaagatg gccctaaatt cttgaagtct gttgatgctg ccattgttga tatggttcct   1080

ggcaagccca tgtgtgttga gagcttctcg gactatccat ctttgggttg ctttgctgtt   1140

cgtgatatga gacagatagt tacagtgggt gtcatcaaag cagtggacaa gaagactgct   1200

ggagctggca aggtcaccaa gtctgcccag aaagctcaga aggctaaatg aatattatcc   1260

ctaatacctg ccaccccact cttaatcagt gatggaagaa cagtctcaga actctgtttc   1320

aattggccat ttaagtttag tagtaaaaga ctggttaatg ataacaatgc atcgtaaaac   1380

cttcagaagg aaaggagaat gttctgtgga ccactttggt tttctttttt gcgtgtggca   1440

gttttaagtt actagctttt aaaatcagcc ctttttaatg gaaacaactt gaccaaaaat   1500

ttgtcacaga attttgagac ccatttaaaa agtttaatga ggaaaaaaaa ggtt         1554


<210>  4426
<211>  227
<212>  PRT
<213>  Homosapiens

<400>  4426

Met Arg Lys Ile Val Lys Glu Val Ser Thr Tyr Ile Lys Lys Ile Gly 
1               5                   10                  15      


Tyr Asn Pro Asp Thr Val Ala Phe Val Pro Ile Ser Gly Trp Asn Val 
            20                  25                  30          


Glu Thr Gly Val Leu Lys Pro Gly Met Val Val Thr Phe Ala Pro Val 
        35                  40                  45              


Asn Val Thr Thr Glu Val Lys Ser Val Glu Met His His Glu Ala Leu 
    50                  55                  60                  


Ser Glu Ala Leu Pro Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val 
65                  70                  75                  80  


Ser Val Lys Asp Val Arg His Gly Asn Val Ala Gly Asp Ser Lys Asn 
                85                  90                  95      


Asp Pro Pro Met Glu Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu 
            100                 105                 110         


Asn His Pro Gly Gln Ile Ser Thr Gly Tyr Ala Pro Val Leu Asp Cys 
        115                 120                 125             


His Thr Ala His Ile Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile 
    130                 135                 140                 


Asp His Arg Ser Gly Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys 
145                 150                 155                 160 


Ser Val Asp Ala Ala Ile Val Asp Met Val Pro Gly Lys Pro Met Cys 
                165                 170                 175     


Val Glu Ser Phe Ser Asp Tyr Pro Ser Leu Gly Cys Phe Ala Val Arg 
            180                 185                 190         


Asp Met Arg Gln Ile Val Thr Val Gly Val Ile Lys Ala Val Asp Lys 
        195                 200                 205             


Lys Thr Ala Gly Ala Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln 
    210                 215                 220                 


Lys Ala Lys 
225         


<210>  4427
<211>  1863
<212>  DNA
<213>  Homosapiens

<400>  4427
tactttcccc tgctggtgcc caagaccacc gtggaaggaa tggctaaagg ataaggtgga     60

ggagacaagt gagttagaat ggggcttgtt acccccagaa gaattttccc aagtgaatgg    120

aatcattctt caaaagaaaa tgtgcgattt ctgggataag atctggaact tccaagccaa    180

gcctgatgac ctgctcattg cttcttaccc caaagcagga accacttgga cacaggaaat    240

tgtagatctg atacaaaatg atggcgatat tgagaaaagc aggcgcgctt ccattcaact    300

tcaacaccct ttcctggagt ggataagaat gacacactgt gggattgacc aggctaacac    360

aatgccttcc ccaaggaccc tgaaaactca tcttcctgta caactactgc ctccatcctt    420

ctgggaggaa aactgtaagt gtccaagagg gagaatctga gacccacttt cctgaggtca    480

tccaatcccc tcccatctta tcaggggtat ggtatggcag ctgtggcaga gggatggagg    540

agaggagaca ccagagggaa aaaaaaaacg caaatcctgt tcacccagga ggtcaacaat    600

ggaaggaata cagaggagaa agcaccagga gggtgtagca ggcatacccc gagatgaaga    660

ggggtttggg cgaagttgga tgtgcaaaca actcaacccc accatgacat gaaggaggcc    720

accgtgtgag cacagggcct ggaacaatgg gtgtaatgag ttactgccac gtcagagaaa    780

ttggttgctc ctgttgatat ggtttgactg tgtccccacc caaatctcat cttgaattgt    840

acttcccata atccccacat gttgtgggac gcacccggtg gcaggtaatg gaatcatggg    900

tggttgcctc catgctgttc tcatcatagt gagttctcat gggatctgat ggttttctaa    960

ggggcttttc ccctttttct cagcacttcc ttttgctgcc atcatgtgaa gaaggatatg   1020

tttgcttccc tttccaccat gattgtaaat ttgctgaggc ctccccagcc atgcggaact   1080

gtgagtcagt taaacctctt ttctttataa atcacccagt ctcaggtatg tccttatagg   1140

agcctgagaa cagactaata cacctgtcaa tgccaaaatg atatattttg gtggatttaa   1200

aattagcaaa gccagcctgc ccaaccacaa acacctccat ctcaggcaca tggtactgct   1260

ttaaataaat atcagtagga catgaaaggt tgggtctgaa aagtcatcac ctacctaact   1320

tcctcagatt cctacctttt tttatattaa tcttgaagct tgctctccct atctaatttt   1380

gtatagattt aggaatgtta aagtgtgtgg ataggctgat gctataggtt gcttctaggg   1440

gaggaatctg ccaagagata ctgacccctg accctagtca tagactgttc tcacttcacg   1500

gtaagtcaat aaaatgatag ctttcctgtt tgagggatgc ccaaattctt tgcaaaatct   1560

aattacaagt ctgaataggc agtaaaattt gttcttgcta tttatataat tgtaaacttt   1620

aactcagaaa tggacattat aagctgttct cagagtatcc aaagatcagg ttggcaccaa   1680

caggtcccga gtaagtcagg ttttcttcac ccctccctgt gtccctctgg ggaccgagca   1740

cgtccaggga gcaaggagca gaccagtcag caaaatgtaa aacctgtctt aacctggaag   1800

gtggggctgt cttatccaca tttggctcca cctctgagct aacttctgat taaagctgat   1860

cta                                                                 1863


<210>  4428
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  4428

Met Cys Asp Phe Trp Asp Lys Ile Trp Asn Phe Gln Ala Lys Pro Asp 
1               5                   10                  15      


Asp Leu Leu Ile Ala Ser Tyr Pro Lys Ala Gly Thr Thr Trp Thr Gln 
            20                  25                  30          


Glu Ile Val Asp Leu Ile Gln Asn Asp Gly Asp Ile Glu Lys Ser Arg 
        35                  40                  45              


Arg Ala Ser Ile Gln Leu Gln His Pro Phe Leu Glu Trp Ile Arg Met 
    50                  55                  60                  


Thr His Cys Gly Ile Asp Gln Ala Asn Thr Met Pro Ser Pro Arg Thr 
65                  70                  75                  80  


Leu Lys Thr His Leu Pro Val Gln Leu Leu Pro Pro Ser Phe Trp Glu 
                85                  90                  95      


Glu Asn Cys Lys Cys Pro Arg Gly Arg Ile 
            100                 105     


<210>  4429
<211>  2525
<212>  DNA
<213>  Homosapiens

<400>  4429
atttcagcac cccaggctag tctgggaggc tggcgcaaac gcagcgggtg gctggggtag     60

gggctcattg ggagcccacg gagcgcggcg gcggctcggg ggccgagttc cctacaacaa    120

ggatggcggt gacgggcgca gggagcgggg cccggctctc cttgcctcga ggctcctctg    180

attccactcg cgtggctgcg cggccctggc agcggccttc gtcccggggg tgggagctac    240

acagggatcc gccccgtcct ggcgaggacg cctgaggggg ctctgtggta aggctctgtc    300

gggcaggccg ggcttccggg aggacctggt ctggatcggt caccgctggg tgcctgagct    360

ccgcatggag cctgcagcct ttgtttaact tataaagaaa tgggggctcc gagcagtcaa    420

gaagaacatg ccccaagtta ttcgtcagtg aggcggaaat tgtggtgtac ttgtgtaagt    480

ttacatttta tactttacca ttatactgtg ctccaaatta tctgatattt actttcaaag    540

tatgtgtagg aagtttacta tgacgatgca gagacattgt acagaatcca gtcccttgat    600

tctcaggtcc ccagaacact cacttcacaa ttttgttgac cttttctgtc aacttaaacc    660

tggcactctc ttggctggct ttctctgctc tttctgggca ctccaaagct tctgtactta    720

catgctacaa ctccagtcac aggaagatgc tgagttcttt agtcccagat ccatattcct    780

gagaaaacct aattgcctag gctcatgtca taactctgta tctgtttcag ttgattatgg    840

ctgggcctac tgcccctctg tatggtggtg gggcaaaagt tcccagagag aggcaggggt    900

gacagggact gttgtctcaa atgctaggca gacatctgga gtggtaacca ctacatctgt    960

tcacagtgag cacatccttg cagggaaact gggttaatca tctctattat tgaaactcag   1020

aggtatagtg tttcttcata ggaattttct ttccttattt gagatggggg tctcactttg   1080

ttgcccaggc tggagtgcag tggtgtgtga tcttggctca ctgcagcctc ccctcccgag   1140

ttcaagtgat tctcctacct cagcctgctg agtagctggg actacaggca tgggccaaca   1200

tgcctggcta atttttgtat ttttcgtaga gacaagtttt caccatattg gccaggctgg   1260

tcttggactc ctgacctcag gtgatctgcc caccctggcc tccctaagtg ccgggatgac   1320

aggtgtgagc catcgcgccc agcctattta taggaatttt ctgtaggtat ataagtaata   1380

atttgaaggt cccaactaga tgccttttcg tgtaaccgta tcttgaatgg aacattttct   1440

ttctacgtaa ttatacataa ataacccaat gctttttaat acccacgaaa aaccattagc   1500

tcaaagacac ttgcaaactt gtatcaggtt gttctccttg gtgtgtatta agtttgaaaa   1560

ggggattttc agataccaag acgaagcaga agtcttccac caagttgaaa tcatcacgtt   1620

gcaatttaat catatgatac aaccaatttt ttgatgtgtt atgccattcg ccaaatacca   1680

aaaatttttt aggggaaact ttacatcctc aatactatac acttccagct acaccaccac   1740

ctaacagaga ctttaaaaag aatacaaagt acggtatgcc ttctcagtgc cttgttagta   1800

attcagttac agttctgccg aactttcttt aaaggaatac aattctcaat cttacaccgt   1860

tcagagcaca agcatagctt attgtataca agagatgtgc atcagttccc actcctcagg   1920

gactgtatga atttggcttt ttttttgacg gagtctcact ctgtcaccgg gctggagtgc   1980

agtagtgtga tcttggctca ctggactctg cctcccgggt tcaagtgatt ctcctgcctc   2040

agcctcccga gtagctggga ctacaggtgc acaccactat gcccagctga ttttttgtgt   2100

gtttttagta gagatggggt ttcaccatgt tggccaggat ggtcttgatc tcttgacctc   2160

atgatctacc cgctttggcc tcccaaggtg ctgggattac aggcatgagg cactgtgctg   2220

ggccaaattt ggttcttgtg gcatctgtgt ttctctttct gctctgtctc tccccatatc   2280

ctagtccaaa catccaaaga aattaattac ctccaggaga tcgagaccat cctggctaac   2340

acggtgaaac cccgtctcta ctaaaaatac aaaaaattag ccgggcatgg tggcgggcgc   2400

ctgtggtccc agctacttgg gaggctgggg cgggagaatg gcgtgaaccc gggaggcaga   2460

gcttgcagtg agccgagatc gcgccattgc actccagcct gggcgacaga gcaagactct   2520

gtctc                                                               2525


<210>  4430
<211>  151
<212>  PRT
<213>  Homosapiens

<400>  4430

Met Cys Arg Lys Phe Thr Met Thr Met Gln Arg His Cys Thr Glu Ser 
1               5                   10                  15      


Ser Pro Leu Ile Leu Arg Ser Pro Glu His Ser Leu His Asn Phe Val 
            20                  25                  30          


Asp Leu Phe Cys Gln Leu Lys Pro Gly Thr Leu Leu Ala Gly Phe Leu 
        35                  40                  45              


Cys Ser Phe Trp Ala Leu Gln Ser Phe Cys Thr Tyr Met Leu Gln Leu 
    50                  55                  60                  


Gln Ser Gln Glu Asp Ala Glu Phe Phe Ser Pro Arg Ser Ile Phe Leu 
65                  70                  75                  80  


Arg Lys Pro Asn Cys Leu Gly Ser Cys His Asn Ser Val Ser Val Ser 
                85                  90                  95      


Val Asp Tyr Gly Trp Ala Tyr Cys Pro Ser Val Trp Trp Trp Gly Lys 
            100                 105                 110         


Ser Ser Gln Arg Glu Ala Gly Val Thr Gly Thr Val Val Ser Asn Ala 
        115                 120                 125             


Arg Gln Thr Ser Gly Val Val Thr Thr Thr Ser Val His Ser Glu His 
    130                 135                 140                 


Ile Leu Ala Gly Lys Leu Gly 
145                 150     


<210>  4431
<211>  3371
<212>  DNA
<213>  Homosapiens

<400>  4431
atgaggaaag agggtccggg gcgctgggga gttggggaga cgatggagcg acggcgagcg     60

agcctgcttc ctggagggag tgcagacaag gaccaggagc gggagccgag cctcgcggcc    120

cggggcacgg cgccgcccgc ccctccccgg cagtgcctcc cgaccccctg ccctccgctg    180

ggacatggcc tgaggccccg cccgccgccc gggactcctc ccccccgctg cccccggacc    240

ctcgccccag gaccgcgggg tctcttcccg gccccgccgc ccgccccggc gagaacaggc    300

ccggcgggca aggcggcggc ggaccgaggg aggcctggcc cggcagcggg gagaagggtg    360

cggcgcagcc cgagtttccc accttttctc ctggcccaga cgcggctggg gcggacggga    420

cctctcgcgc tctgcctcct cctcttgctt catggagcca tgcgcctggg tgggggctcc    480

cgagagaagc tggcctgcgg gcgggccgga cgcgctgcgc ggacggggcg gggcgaagga    540

ggccggcggg cggaggagga agcggcgggg cggcggcggc ggcggcggcc gggaagaact    600

agaggtattc cccgggcggc tggaggactg agtcgagccg ggacccgagt cctccggtat    660

cccagcagcc accggaggca gtgaggtaat ggaggaagaa tgtagggagt cctccagtgg    720

accacactcc ttctagcgag ccgcggaaac catagagatc agggctcagc cggagggccg    780

gcccactgct gtcacgtggc ctccatccgt gcgctttatt ggctggtgct ggctttacgg    840

ggttgaattt tggacgctgc ctgccattcg tgggaccgag tttcaggcag ctggaataaa    900

gagagacatc gggggaaagc cgcgagaagg ccagcgtccc tggctgggag cagagctagc    960

cgagtagggc gcccggctgt caaaactggc cggcgcagtg cacgctgggc cgccccggag   1020

cggtcgcaga gcccgtcggg agtcgtagtc cgggacgggc ccgcagcatt gtccgcgacg   1080

cagctcggga tccgcgtcgg gttgtcggcc gggttgctgc caggcaccgt cgagcgttag   1140

ccacccagca ttgagctgcc agcggctgtt ctccctaagc accctcgctc acgtcgcctc   1200

gcctcgcctc gcctgaccgg ccgcagcctt ggataccagc cttaaatcga gccgactacg   1260

gcccagcccc gcccgcggcg aagtgcgcgg ggttcggtgc cagccgctcg cccctggccg   1320

ggccagcctc ttgatgcacc ggggacgggc gcgcccatcc gactcttcga ggggcggcag   1380

ggccccatct gtgtctttcg ctctcgagcc cccagctaga gttggcttca gcggaatacc   1440

tactgtgcag gattattcaa caagccgatt gatcacattc ttcagctcta gcagtgcaaa   1500

ggcttcactg aaaaagaaca ttacaaattt tttttgaaag aaatttgggg gtaaatttaa   1560

ttttaaatac tgatttttga taacatttga tcttatgaca gcatttgtat ttttaattac   1620

agataggatt acactaaaag tcatttctga cctgctccct tacccttatg gctaaaataa   1680

actgctaggc cctgaagcaa aggcgagcca tgttctagag caatgtcttt cttgtattaa   1740

aatacggccc catgctcaca tataggctgt tttgtgtttt gcttttctgt tgatgcacaa   1800

aggaatcctt gatatgtttg tcctcaaaga ccaaagacaa gtatctagta aaaaatgcaa   1860

atcatatcta acagtgaagc tttccagcaa aaaccttctg ctctagaatg cataattatg   1920

cgagcataag atctactact ctagactttt agcataatta cctataggca gcaaaaccct   1980

agtcaattga gtgtctggtg cctcttggac ctggacttct ccaagagaat gggcaaggag   2040

gacgaaaagg aagagacagc tatgctttgt gaaacaggag gtgacttaaa aaaaaaattc   2100

tatagcagtc ttcttaattc ctgttacaga cttgatacgc ttatctgctg ttgaggacac   2160

ggttgccagt ttctaacctt ctctgtctgc ctgaaaaact agaaattaga tgatcatatg   2220

gcctagagcc agaagtgcag gaggcagaaa gccaggggcc agtttttttc tttttgtttc   2280

tgaataagaa ggccaaatcc tgacttaaaa taatcaaaat aaattttacg gagtgacggt   2340

ctttccagct gaaaacctta aaacatggca tctggaagaa ggccttagtc tattgctccc   2400

aggatggtac tatatagtca ttaaatagcc cacagataag ggagttattg ccccctcgtt   2460

attgggctgc caggaattaa atgatggaac taagtttcac ttgaaacatt cccaaattaa   2520

aacaaaaaca agccttgctt tgagctgttg aaaaggcatt ttactgagaa gatccagatg   2580

ctattgctgt tcttaaatga tgttgaaagg caaagggtca ggactttcaa aaagtcactt   2640

tgaggtcacc tcacataagc aagcaacagt ttgaactgat gcaaaaacaa acaatgaaat   2700

tatgaacagg aggaagaaac taaaatgagg gcagtatatg ccataaatat ggaagaggct   2760

gtctcttatt tatcttctca tttcctgtac ataatacaga aacctggtat gtaataggca   2820

tacaattatt tgtggctcaa ctgaataaac gaagatggaa accagcaagc agcgggcaga   2880

taatatactt gggaaaggag aactgcagag acgctgggtg gttcaaggct tctgcatgat   2940

cctcaaatgt caccccaatc tgctgtgaca tagctatacc actcatcaga ataccccaaa   3000

acaaattgtc tgcctccctt atgtacaact tttattattt cttatctcgg ttggttaaga   3060

atatgtagta atggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggcc   3120

gaggcaggag gatcacctga ggtcaggagt tcgagaccag cctcaacatg gagaaacccc   3180

gtctctacta aaaatacaaa attagccggg cgtggtggtg catacctgta attccagcta   3240

ctcgggaggc tgaggcagga gaattgcttg aacctgggag gcagagtttg cggtgagctg   3300

agatcgcgcc attgcactcc atccagcctg ggcaacaaga gcgaaactcc atctcaaaaa   3360

aaaaaaaaaa a                                                        3371


<210>  4432
<211>  227
<212>  PRT
<213>  Homosapiens

<400>  4432

Met Arg Lys Glu Gly Pro Gly Arg Trp Gly Val Gly Glu Thr Met Glu 
1               5                   10                  15      


Arg Arg Arg Ala Ser Leu Leu Pro Gly Gly Ser Ala Asp Lys Asp Gln 
            20                  25                  30          


Glu Arg Glu Pro Ser Leu Ala Ala Arg Gly Thr Ala Pro Pro Ala Pro 
        35                  40                  45              


Pro Arg Gln Cys Leu Pro Thr Pro Cys Pro Pro Leu Gly His Gly Leu 
    50                  55                  60                  


Arg Pro Arg Pro Pro Pro Gly Thr Pro Pro Pro Arg Cys Pro Arg Thr 
65                  70                  75                  80  


Leu Ala Pro Gly Pro Arg Gly Leu Phe Pro Ala Pro Pro Pro Ala Pro 
                85                  90                  95      


Ala Arg Thr Gly Pro Ala Gly Lys Ala Ala Ala Asp Arg Gly Arg Pro 
            100                 105                 110         


Gly Pro Ala Ala Gly Arg Arg Val Arg Arg Ser Pro Ser Phe Pro Pro 
        115                 120                 125             


Phe Leu Leu Ala Gln Thr Arg Leu Gly Arg Thr Gly Pro Leu Ala Leu 
    130                 135                 140                 


Cys Leu Leu Leu Leu Leu His Gly Ala Met Arg Leu Gly Gly Gly Ser 
145                 150                 155                 160 


Arg Glu Lys Leu Ala Cys Gly Arg Ala Gly Arg Ala Ala Arg Thr Gly 
                165                 170                 175     


Arg Gly Glu Gly Gly Arg Arg Ala Glu Glu Glu Ala Ala Gly Arg Arg 
            180                 185                 190         


Arg Arg Arg Arg Pro Gly Arg Thr Arg Gly Ile Pro Arg Ala Ala Gly 
        195                 200                 205             


Gly Leu Ser Arg Ala Gly Thr Arg Val Leu Arg Tyr Pro Ser Ser His 
    210                 215                 220                 


Arg Arg Gln 
225         


<210>  4433
<211>  4060
<212>  DNA
<213>  Homosapiens

<400>  4433
atgaggaaag agggtccggg gcgctgggga gttggggaga cgatggagcg acgggtagag     60

cagcttgggc cgagccgcgg ggcgagcgag cctgcttcct ggagggagtg cagacaagga    120

ccaggagcgg gagccgagcc tcgcggcccg gggcacggcg ccgcccgccc ctccccggca    180

gtgcctcccg accccctgcc ctccgctggg acatggcctg aggccccgcc cgccgcccgg    240

gacccctccc ccacgctgcc cccggaccct cgccccagga ccgcggggtc tcttcccggc    300

cccgccgccc gccccggcga gaacaggccc ggcgggcaag gcggcggcgg accgagggag    360

gcctggcccg gcagcgggga gaagggtgcg gcgcagcccg agtttcccac cttttctcct    420

ggcccagacg cggctggggc ggacgggacc tctcgcgctc tgcctcctcc tcttgcttca    480

tggagccatg cgcctgggtg ggggctcccg agagaagctg gcctgcgggc gggccggacg    540

cgctgcgcgg acggggcggg gcgaaggagg ccggcgggcg gaggaggaag cggcggggcg    600

gcggcggcgg cggcggccgg gaagaactag aggtattccc cgggcggctg gaggactgag    660

tcgagccggg acccgagtcc tccggtatcc cagcagccac cggaggcagt gaggtaatgg    720

aggaagaatg tagggagtcc tccagtggac cacactcctt ctagcgagcc gcggaaacca    780

tagagatcag ggctcagccg gagggccggc ccactgctgt cacgtggcct ccatccgtgc    840

gctttattgg ctggtgctgg ctttacgggg ttgaattttg gacgctgcct gccattcgtg    900

ggaccgagtt tcaggcagct ggaataaaga gagacatcgg gggaaagccg cgagaaggcc    960

agcgtccctg gctgggagca gagctagccg agtagggcgc ccggctgtca aactggccgg   1020

cgcagtgcac gctgggccgc cccggagcgg tcgcagagcc cgtcgggagt cgtagtccgg   1080

gacgggcccg cggcattgtc cgcgacgcag ctcgggatcc gggtcggggt gtcggccggg   1140

ttgctgccgg gcaccgtcga gcgttagcca cccagcattg agctgccagc ggctgttctc   1200

cctaagcacc ctcgctcacg tcgcctcgcc tcgcctcgcc tgaccggccg cagccttgga   1260

taccagcctt aaatcgagcc gactacggcc cagccccgcc cgcggcgagg tgcgcggggt   1320

tcggtgccag ccgctcgccc ctggcggggc cagcctcttg atgcaccggg gacgggcgcc   1380

cccatccgac tcttcgaggg gcggcagggc cccatctgtg tctttcgctc tcgagccccc   1440

agctagagtt ggcttcagcg gaatacctac tgtgcaggat tattcaacaa gccgattgat   1500

cacattcttc agctctagca gtgcaaaggc ttcactgaaa aagaacatta caaatttttt   1560

ttgaaagaaa tttgggggta aatttaattt taaatactga tttttgataa catttgatct   1620

tatgacagca tttgtatttt taattacaga taggattaca ctaaaagtca tttctgacct   1680

gctcccttac ccttatggct aaaataaact gctaggccct gaagcaaagg cgagccatgt   1740

tctagagcaa tgtctttctt gtattaaaat acggccccat gctcacatat aggctgtttt   1800

gtgttttgct tttctgttga tgcacaaagg aatccttgat atgtttgtcc tcaaagacca   1860

aagacaagta tctagtaaaa aatgcaaatc atatctaaca gtgaagcttt ccagcaaaaa   1920

ccttctgctc tagaatgcat aattatgcga gcataagatc tactactcta gacttttagc   1980

ataattacct ataggcagca aaaccctagt caattgagtg tctggtgcct cttggacctg   2040

gacttctcca agagaatggg caaggaggac gaaaaggaag agacagctat gctttgtgaa   2100

acaggaggtg acttaaaaaa aaaattctat agcagtcttc ttaattcctg ttacagactt   2160

gatacgctta tctgctgttg aggacacggt tgccagtttc taaccttctc tgtctgcctg   2220

aaaaactaga aattagatga tcatatggcc tagagccaga agtgcaggag gcagaaagcc   2280

aggggccagt ttttttcttt ttgtttctga ataagaaggc caaatcctga cttaaaataa   2340

tcaaaataaa ttttacggag tgacggtctt tccagctgaa aaccttaaaa catggcatct   2400

ggaagaaggc cttagtctat tgctcccagg atggtactat atagtcatta aatagcccac   2460

agataaggga gttattgccc cctcgttatt gggctgccag gaattaaatg atggaactaa   2520

gtttcacttg aaacattccc aaattaaaac aaaaacaagc cttgctttga gctgttgaaa   2580

aggcatttta ctgagaagat ccagatgcta ttgctgttct taaatgatgt tgaaaggcaa   2640

agggtcagga ctttcaaaaa gtcactttga ggtcacctca cataagcaag caacagtttg   2700

aactgatgca aaaacaaaca atgaaattat gaacaggagg aagaaactaa aatgagggca   2760

gtatatgcca taaatatgga agaggctgtc tcttatttat cttctcattt cctgtacata   2820

atacagaaac ctggtatgta ataggcatac aattatttgt ggctcaactg aataaacgaa   2880

gatggaaacc agcaagcagc gggcagataa tatacttggg aaaggagaac tgcagagacg   2940

ctgggtggtt caaggcttct gcatgatcct caaatgtcac cccaatctgc tgtgacatag   3000

ctataccact catcagaata ccccaaaaca aattgtctgc ctcccttatg tacaactttt   3060

attatttctt atctcggttg gttaagaata tgtagtaatg gccgggcgcg gtggctcacg   3120

cctgtaatcc cagcactttg ggaggccgag gcaggaggat cacctgaggt caggagttcg   3180

agaccagcct caacatggag aaaccccgtc tctactaaaa atacaaaatt agccgggcgt   3240

ggtggtgcat acctgtaatt ccagctactc gggaggctga ggcaggagaa ttgcttgaac   3300

ctgggaggca gagtttgcgg tgagctgaga tcgcgccatt gcactccatc cagcctgggc   3360

aacaagagcg aaactccatc tcaaaaaaaa aaaaaaaaaa aaaagaatat gtagtaatgg   3420

ttaagagtcc actgtggaat cagcctgcat aggtccaaat cccagccctg actgaatacc   3480

tgtgaacaag ttatatcagt gactcaggct tattatctgt aaaatgggga ttatagcatt   3540

cctgcctcat agggatgtta tgagatttaa ataccaataa gtctgtacat tataaacctt   3600

atcagattgg tgtggtgaaa atgctcagta actgagcctc gtgagcatta gaatgttgag   3660

atcagcatga agttagcctg tatactgggc atacacattc ttctggattt gctccttttg   3720

tgagcaatca atgatgagct aaaggcattt gctaactagt aggaatgaaa taaggtttca   3780

gacaggatct tggtgggtga tgtagatttt atctgtccca tttgtcccat ttctcaactg   3840

gaagtgagtc tggccttggt ctgcatctgt gctctcccct tcacaaaagg caggcccaga   3900

gagactccag agatggcccc tgtctcctgt gtgtcctccg ccgctgtgtc cacttgggca   3960

cgtcaaaggt atgatcggta cttatctgat gaaaacaaat ctttgtatat acagttgtct   4020

acctgggttg aatatttcag aggtataaag tagtttaaat                         4060


<210>  4434
<211>  209
<212>  PRT
<213>  Homosapiens

<400>  4434

Met Arg Lys Glu Gly Pro Gly Arg Trp Gly Val Gly Glu Thr Met Glu 
1               5                   10                  15      


Arg Arg Val Glu Gln Leu Gly Pro Ser Arg Gly Ala Ser Glu Pro Ala 
            20                  25                  30          


Ser Trp Arg Glu Cys Arg Gln Gly Pro Gly Ala Gly Ala Glu Pro Arg 
        35                  40                  45              


Gly Pro Gly His Gly Ala Ala Arg Pro Ser Pro Ala Val Pro Pro Asp 
    50                  55                  60                  


Pro Leu Pro Ser Ala Gly Thr Trp Pro Glu Ala Pro Pro Ala Ala Arg 
65                  70                  75                  80  


Asp Pro Ser Pro Thr Leu Pro Pro Asp Pro Arg Pro Arg Thr Ala Gly 
                85                  90                  95      


Ser Leu Pro Gly Pro Ala Ala Arg Pro Gly Glu Asn Arg Pro Gly Gly 
            100                 105                 110         


Gln Gly Gly Gly Gly Pro Arg Glu Ala Trp Pro Gly Ser Gly Glu Lys 
        115                 120                 125             


Gly Ala Ala Gln Pro Glu Phe Pro Thr Phe Ser Pro Gly Pro Asp Ala 
    130                 135                 140                 


Ala Gly Ala Asp Gly Thr Ser Arg Ala Leu Pro Pro Pro Leu Ala Ser 
145                 150                 155                 160 


Trp Ser His Ala Pro Gly Trp Gly Leu Pro Arg Glu Ala Gly Leu Arg 
                165                 170                 175     


Ala Gly Arg Thr Arg Cys Ala Asp Gly Ala Gly Arg Arg Arg Pro Ala 
            180                 185                 190         


Gly Gly Gly Gly Ser Gly Gly Ala Ala Ala Ala Ala Ala Ala Gly Lys 
        195                 200                 205             


Asn 
    


<210>  4435
<211>  1668
<212>  DNA
<213>  Homosapiens

<400>  4435
cctatgcgga cagcatgatg ccaggtctgt gtcaggcatc ggaaatgcag ctgggtagga     60

aactagggct ccttttggga atgttgagtt caccatctac cggaggagaa tgactgaaag    120

tattggttgc gctcatgtct tttttgaccc tcaacttgta gatgcattca ccctagtcca    180

agaaaaccta ttggctttgc ctgacctttt ggccttagaa atgaccttca aacactatag    240

ccatctcagg atagggatag caatgatgta caggaactgg cacagaagga attttctcct    300

gtcacaaggc agaagttgta tggctcctgt gctacttgtc acagcaaact taagcagatc    360

cagaaactgc ctgacccttt actgtacctt cccactccaa aatggggagg ggaactcctg    420

tgcgggagtg ctcagctctc aagggaagac agtcattaac ctgtctaaac tctatgttaa    480

tagaaccttc tcgataattg ctttcattaa gtgtggttaa tgtgaacagt acaagttata    540

gcaagatttg cagaagaaca aagtaaatat ttaagacttt atttcaggat gcagttgggt    600

cgaggcaagg agaagattag tagaagctgt atctgatggt atctgaggtt gaaacacagt    660

gaacctcttg gcagaagtgc cagtcatttc tcatcagtgg ttcacagaat cctaactctg    720

gggaggcaga tgggtgtctc ctggagatgg ttgtgtgttc aggttttctc ctttcgcttc    780

tggcctctgt cagacatgaa tgacatggtg atgaagataa actgccttcc ctgtactgcc    840

caggaatgca atgaggatta agaaggtggc ttttagcctg tgtctatgcc acatggggag    900

gatggttgct ccctgagggc agaaggccat tattagcaac tgagttggcc aggagtgtgt    960

gccatgccgg gctgggtgta cggagctgtc aagccaggca cctggggatt aatttagcat   1020

gggttttcat gcccccgggc taccagtgac catacagcca tcatctctac ctttgagttg   1080

atgtgtataa ctgaataata gtgctgtgtt ttcaaaagga aaggcttaaa aaacagtgct   1140

tctgtagtac aaggagggat gctctgctga aaatctggaa attacagcta agcaaaaaga   1200

tgaaaataca aagtagctgt tattctacca cccagagatc gatttgtttc tttactaaca   1260

gatacggcaa gtgcctgttc tgtgccaggc actgtctagg cactggagat agtgatgagc   1320

aaaaccatct cttctttctg gagatgacac tccagcagtg aaggcagata ggaaacaaat   1380

acataaacac atctggtgaa aaatgcttga ggaacagcaa agtagggtaa gaaattagcg   1440

aaggaagtgg gtgctgtttc aggtttgagg cttgtcaaga aagcctctct gaagaagaga   1500

gattgagcag agacccatat tattgagtga gggaggcctg gggttctcca gctagctgcc   1560

agcaggatca gtctgtacaa cagcccaggg cacattcttc ctgggtgcat ttaagaacca   1620

ctgttgggcc cttttaattc taatacagaa ggtggcctat taaaacca                1668


<210>  4436
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  4436

Met Thr Glu Ser Ile Gly Cys Ala His Val Phe Phe Asp Pro Gln Leu 
1               5                   10                  15      


Val Asp Ala Phe Thr Leu Val Gln Glu Asn Leu Leu Ala Leu Pro Asp 
            20                  25                  30          


Leu Leu Ala Leu Glu Met Thr Phe Lys His Tyr Ser His Leu Arg Ile 
        35                  40                  45              


Gly Ile Ala Met Met Tyr Arg Asn Trp His Arg Arg Asn Phe Leu Leu 
    50                  55                  60                  


Ser Gln Gly Arg Ser Cys Met Ala Pro Val Leu Leu Val Thr Ala Asn 
65                  70                  75                  80  


Leu Ser Arg Ser Arg Asn Cys Leu Thr Leu Tyr Cys Thr Phe Pro Leu 
                85                  90                  95      


Gln Asn Gly Glu Gly Asn Ser Cys Ala Gly Val Leu Ser Ser Gln Gly 
            100                 105                 110         


Lys Thr Val Ile Asn Leu Ser Lys Leu Tyr Val Asn Arg Thr Phe Ser 
        115                 120                 125             


Ile Ile Ala Phe Ile Lys Cys Gly 
    130                 135     


<210>  4437
<211>  1668
<212>  DNA
<213>  Homosapiens

<400>  4437
cctatgcgga cagcatgatg ccaggtctgt gtcaggcatc ggaaatgcag ctgggtagga     60

aactagggct ccttttggga atgttgagtt caccatctac cggaggagaa tgactgaaag    120

tattggttgc gctcatgtct tttttgaccc tcaacttgta gatgcattca ccctagtcca    180

agaaaaccta ttggctttgc ctgacctttt ggccttagaa atgaccttca aacactatag    240

ccatctcagg atagggatag caatgatgta caggaactgg cacagaagga attttctcct    300

gtcacaaggc agaagttgta tggctcctgt gctacttgtc acagcaaact taagcagatc    360

cagaaactgc ctgacccttt actgtacctt cccactccaa aatggggagg ggaactcctg    420

tgcgggagtg ctcagctctc aagggaagac agtcattaac ctgtctaaac tctatgttaa    480

tagaaccttc tcgataattg ctttcattaa gtgtggttaa tgtgaacagt acaagttata    540

gcaagatttg cagaagaaca aagtaaatat ttaagacttt atttcaggat gcagttgggt    600

cgaggcaagg agaagattag tagaagctgt atctgatggt atctgaggtt gaaacacagt    660

gaacctcttg gcagaagtgc cagtcatttc tcatcagtgg ttcacagaat cctaactctg    720

gggaggcaga tgggtgtctc ctggagatgg ttgtgtgttc aggttttctc ctttcgcttc    780

tggcctctgt cagacatgaa tgacatggtg atgaagataa actgccttcc ctgtactgcc    840

caggaatgca atgaggatta agaaggtggc ttttagcctg tgtctatgcc acatggggag    900

gatggttgct ccctgagggc agaaggccat tattagcaac tgagttggcc aggagtgtgt    960

gccatgccgg gctgggtgta cggagctgtc aagccaggca cctggggatt aatttagcat   1020

gggttttcat gcccccgggc taccagtgac catacagcca tcatctctac ctttgagttg   1080

atgtgtataa ctgaataata gtgctgtgtt ttcaaaagga aaggcttaaa aaacagtgct   1140

tctgtagtac aaggagggat gctctgctga aaatctggaa attacagcta agcaaaaaga   1200

tgaaaataca aagtagctgt tattctacca cccagagatc gatttgtttc tttactaaca   1260

gatacggcaa gtgcctgttc tgtgccaggc actgtctagg cactggagat agtgatgagc   1320

aaaaccatct cttctttctg gagatgacac tccagcagtg aaggcagata ggaaacaaat   1380

acataaacac atctggtgaa aaatgcttga ggaacagcaa agtagggtaa gaaattagcg   1440

aaggaagtgg gtgctgtttc aggtttgagg cttgtcaaga aagcctctct gaagaagaga   1500

gattgagcag agacccatat tattgagtga gggaggcctg gggctctcca gctagctgcc   1560

agcaggatca gtctgtacaa cagcccaggg cacattcttc ctgggtgcat ttaagaacca   1620

ctgttgggcc cttttaattc taatacagaa ggtggcctat taaaacca                1668


<210>  4438
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  4438

Met Thr Glu Ser Ile Gly Cys Ala His Val Phe Phe Asp Pro Gln Leu 
1               5                   10                  15      


Val Asp Ala Phe Thr Leu Val Gln Glu Asn Leu Leu Ala Leu Pro Asp 
            20                  25                  30          


Leu Leu Ala Leu Glu Met Thr Phe Lys His Tyr Ser His Leu Arg Ile 
        35                  40                  45              


Gly Ile Ala Met Met Tyr Arg Asn Trp His Arg Arg Asn Phe Leu Leu 
    50                  55                  60                  


Ser Gln Gly Arg Ser Cys Met Ala Pro Val Leu Leu Val Thr Ala Asn 
65                  70                  75                  80  


Leu Ser Arg Ser Arg Asn Cys Leu Thr Leu Tyr Cys Thr Phe Pro Leu 
                85                  90                  95      


Gln Asn Gly Glu Gly Asn Ser Cys Ala Gly Val Leu Ser Ser Gln Gly 
            100                 105                 110         


Lys Thr Val Ile Asn Leu Ser Lys Leu Tyr Val Asn Arg Thr Phe Ser 
        115                 120                 125             


Ile Ile Ala Phe Ile Lys Cys Gly 
    130                 135     


<210>  4439
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  4439
ggtctaggag ggagcgcgcc gcacgcgtga gtaaacagcc ggagctggga aagtcgagct     60

ctggcagcgt ctgggtgctg aggggcagag gcggagagaa ccctgtcctg atcttcctag    120

ggtggccgac atgacggcca ggggtcagag ccccctcgcg ccgctgttgg agactttgga    180

agacccttct gcctcccatg gagggcagac tgacgcttac ctgactctga ccagtcgtat    240

gactggagaa gaaggaaaag aagtaattac agaaattgag aaaaaacttc ctcggctgta    300

caaagtttta aagactcaca tttccagtca aaactcggag ctgagtagtg ctgctctaca    360

agccctgggg ttttgcttat ataatcccaa aattacctca gaattatcag aggcaaatgc    420

tctagaattg ctttcaaaat tgaatgatac cattaagaat tcagacaaaa atgtacgtac    480

tagagcactt tgggtgatat ctaagcagac atttccctct gaagtggttg gcaaaatggt    540

atccagtata attgattcat tagaaatact gtttaacaaa ggagagacgc attctgctgt    600

tgttgatttt gaagcattaa atgttatcgt aaggctaatt gaacaagccc caattcaaat    660

gggagaagag gcagtgaggt gggcaaaact ggtcatacct ttagtggttc attcagcaca    720

aaaggtacat ttgcggggag caactgctct ggagatggga atgccattat tgcttcagaa    780

acagcaagaa atagcatcta ttacggagca gcttatgact actaaattaa tctcagaact    840

tcagaagcta tttatgagta aaaatgagac ttacgtgtta aaattatggc ctttgtttgt    900

caaactactt ggaaggacct tgcatcgaag tgggagtttc atcaattctc tcttgcaact    960

agaagaactt ggatttcgta gtggagcacc catgattaaa aagatagctt ttattgcttg   1020

gaagagttta atagataatt ttgctttaaa tccagatata ctatgtagtg caaaaagact   1080

caagttgtta atgcagcctt tgagttccat ccatgtgaga acagaaactc tagcattaac   1140

aaaactagaa gtctggtggt atttactgat gagacttgga cctcatcttc ctgctaattt   1200

tgaacaggtt tgtgtgcctc tgattcaaag tacaataagc attgattcta atgcctcacc   1260

tcagggcaat tcgtgtcatg tagctacatc tccaggttta aatcctatga ctcctgtaca   1320

caaaggtgct tcctccccgt acggagcccc gggaactccc cgaatgaacc tgagttcgaa   1380

tttaggtgga atggccacaa tcccatccat tcaacttttg ggacttgaaa tgttgcttca   1440

tttcttgttg ggtccagaag ccttgagttt tgctaagcaa aataaacttg tgctgagctt   1500

agagccattg gaacatccgt taatcagcag cccttccttt ttttccaaac atgcaaatac   1560

acttatcact gctgttcatg atagctttgt tgcagttgga aaagatgccc ccgatgtggt   1620

tgtcagtgct atctggaagg agctaattag cttggtgaag tcagttactg aatcaggtaa   1680

caaaaaagag aaaccaggtt ctgaagtttt gactctctta ttaaagtctt tggaaagcat   1740

agtaaagtct gaagtatttc ctgtatcaaa aacgctggtc ctcatggaaa ttacaattaa   1800

aggacttcct cagaaagtat taggttcacc agcatatcag gttgctaata tggatattct   1860

taatggaact ccagctttgt tcttaattca attaattttc aacaatttct tggaatgtgg   1920

tgtatcagat gaaaggttct ttctcagttt ggaatcactt gtaggctgtg ttctttctgg   1980

tccaacttca ccactagctt tcagtgactc agttttaaat gttattaatc aaaatgcaaa   2040

gcagttggaa aataaggagc atctctggaa aatgtggagt gttatagtca ccccattaac   2100

tgaattgatt aatcagacca atgaagtaaa tcaaggtgat gccttagaac ataattttag   2160

tgccatctat ggtgcattga ctttaccagt aaaccacatt ttttcagaac agagatttcc   2220

agtggccacc atgaagactt tgcttagaac ttggtcagaa ttatatagag catttgctcg   2280

ttgtgctgct ttggtggcaa cagcagaaga gaacttgtgc tgtgaggaac tttcttccaa   2340

gataatgtcc agtttggaag atgaaggctt ttctaatttg ttgttcgtgg atagaattat   2400

ttatattatt actgtaatgg ttgattgcat tgacttctca ccatataata ttaaatatca   2460

gcccaaagtt aaatcaccac agagaccttc agattggtcc aaaaagaaga atgagcccct   2520

agggaaattg acttctttat ttaaacttat tgtgaaagtg atctattctt tccacacact   2580

gagcttcaag gaagcacatt ctgataccct cttcactatt ggcaactcaa tcaccggcat   2640

tatttccagt gtacttgggc atatttcttt gccttctatg atccgaaaaa tatttgcaac   2700

tttaacaaga cctctggcat tattttatga aaactcaaag cttgatgaag ttcctaaagt   2760

atatagttgt ctgaacaaca agttagaaaa gctactggga gaaattattg cttgtctgca   2820

attcagctac accggaactt atgatagtga acttcttgaa caactctccc cactattatg   2880

cataatattt ctgcacaaga ataaacagat tcgaaaacag agtgctcagt tctggaatgc   2940

cacttttgcc aaagtgatga tgttggttta tcctgaagag ttaaaaccag tactaacaca   3000

agccaaacaa aaatttctgc tcctgttgcc tggtttggaa actgttgaaa tgatggagga   3060

atccagtgga ccatattctg atggaacaga aaattcacaa ctaaatgtga agataagtgg   3120

catggagaga aaatcaaatg gaaaaagaga ttcatttttg gcacaaacaa agaataaaaa   3180

agaaaatatg aaaccagcag ccaaactgaa acttgaatct tcgtctttaa aagtaaaggg   3240

tgaaattctt ttggaagagg aaaagtctac tgactttgtg tttatacctc cagaaggaaa   3300

agatgcaaag gaaagaatat taactgatca tcaaaaagaa gttctcaaaa caaagcggtg   3360

tgatattcct gccatgtata ataatctgga tgtttcccaa gataccttat ttactcagta   3420

tagtcaggaa gagcctatgg aaattcctac tttaaccaga aaaccaaagg aggattctaa   3480

gatgatgatt acggaggagc aaatggacag tgacattgtc attcctcaag atgtcacgga   3540

agactgtggt atggctgaac atcttgaaaa gtcctccctt tcgaataatg agtgtggttc   3600

tcttgacaaa accagtccag aaatgtcaaa cagtaataat gatgaaagaa aaaaagcttt   3660

aatttcatca aggaaaacat caactgaatg tgcatctagt acagaaaatt ctttcgttgt   3720

cagcagtagt tcagtttcta ataccactgt tgctggaact cccccatacc ctacaagtcg   3780

gaggcaaacc tttattactt tggagaagtt tgatggttca gaaaatagac cttttagtcc   3840

atcccccttg aataatattt catcaactgt tacagtgaaa aataaccagg aaaccatgat   3900

taaaacagat tttctaccaa aagcaaagca aagagaaggg actttttcaa aatctgattc   3960

tgaaaaaata gtgaatggaa ctaagagatc aagccggaga gctggtaaag ctgaacaaac   4020

agggaataaa aggtctaagc ccttaatgag atctgagccg gagaaaaata ctgaggaatc   4080

tgttgaaggc attgtagtct tagaaaataa cccacctggt ttgcttaatc aaacagaatg   4140

tgtgtcagat aatcaggttc atctttctga atctacaatg gagcatgaca atacaaagct   4200

taaagcagca acagtggaaa atgctgtatt attggaaact aatactgtag aggagaaaaa   4260

tgtagaaatt aatttggaat ccaaagagaa tacaccccca gtagtaatat cagcagatca   4320

aatggtaaat gaggatagtc aggttcagat aactccaaat cagaaaaccc ttagacggtc   4380

ttcaaggcga cgttcagaag tagtagagtc taccactgaa agccaagata aggaaaatag   4440

tcatcaaaaa aaggaacgac gtaaggaaga agaaaaacct cttcagaaga gtccattgca   4500

tataaaagat gatgtgttac ctaaacaaaa actgattgct gaacaaactc tacaggagaa   4560

tttaattgag aaaggaagta atttacatga gaagactctt ggggaaacta gtgctaatgc   4620

agaaactgaa caaaataaaa aaaaggcaga ccctgagaac attaagtctg agggggatgg   4680

tacccaggac attgtagata agtcctctga gaaactagtc agaggccgaa cacggtatca   4740

aactagaaga gcatctcagg gtttgctttc cagcattgaa aactcagaat ctgatagttc   4800

ggaggcaaaa gaagaaggtt ctaggaagaa gagatctgga aaatggaaaa acaaaagcaa   4860

tgaaagtgtt gacattcaag atcaagaaga gaaagtggtg aaacaggaat gtataaaagc   4920

tgaaaatcag tcacatgatt ataaagcaac ttctgaagaa gatgtaagca taaaatctcc   4980

gatttgcgaa aaacaagatg aaagtaatac tgtaatatgt caggattcta cagtaacttc   5040

agatttgttg caagttcctg atgatttacc aaatgtgtgt gaggaaaaaa atgaaactag   5100

caaatatgca gaatattcct ttacaagtct acctgtgcca gaatcaaatc taaggactag   5160

aaatgccatt aagagattac ataagcgaga ctcttttgat aattgtagtt tgggagaatc   5220

ctcaaaaata gggatatcag atatttcttc gctttcagaa aaaacttttc aaacacttga   5280

atgccaacac aagagaagta ggagggtgag gagatctaaa ggttgtgatt gctgtgggga   5340

aaaatcacaa cctcaggaaa agtcactcat tgggttaaag aatacagaaa ataatgacgt   5400

agagattagt gaaacaaaaa aggcagatgt gcaagcacct gtaagcccat cagaaacttc   5460

tcaagctaat ccatattctg aaggacaatt tttagatgaa catcatagtg tgaattttca   5520

tttgggtctc aaagaggata atgatactat taatgattca ttaattgttt ctgaaaccaa   5580

atcaaaagaa aacactatgc aagaatctct tccttctgga atagtaaact ttagagagga   5640

aatttgtgat atggattcta gtgaagcaat gtctcttgaa agccaggagt cacctaatga   5700

aaattttaaa actgttggcc cgtgtttagg agactcgaaa aatgtttcac aggaatcttt   5760

ggagacaaaa gaagaaaaac cagaagaaac cccaaaaatg gaactgagtc tagagaatgt   5820

tactgttgaa ggaaatgcat gtaaagtaac agaatccaat ctagagaaag caaaaactat   5880

ggaattgaat gtaggaaatg aagctagctt tcatggacaa gagagaacca aaactggtat   5940

ttctgaagaa gcagcaatag aagaaaataa aagaaatgat gactctgaag cagacacagc   6000

taaactgaat gccaaagaag tagcaactga ggaatttaat tcagatatta gtctttctga   6060

taatactaca cctgtaaaat tgaatgctca aactgagatt tctgaacaaa cagcagctgg   6120

ggaactagat ggaggaaatg atgtatctga tctacactca tctgaagaaa cgaataccaa   6180

aatgaaaaat aatgaagaaa tgatgatcgg cgaggcaatg gctgaaactg gccatgatgg   6240

tgaaacagag aatgagggca taactaccaa aacctcaaag cctgatgaag ctgaaacaaa   6300

catgttgact gcagaaatgg acaactttgt ttgtgacaca gttgaaatga gcactgaaga   6360

aggaatcatt gacgctaata aaactgaaac aaatactgag tatagtaaat ctgaagaaaa   6420

attagataac aatcaaatgg taatggaaag tgatatttta caggaagatc accatacttc   6480

acagaaagtg gaggaaccat cacagtgtct ggcatctgga acagctatct ctgagctaat   6540

aatagaagac aataatgcat ctcctcaaaa actaagggaa cttgatcctt cacttgtgtc   6600

agcaaatgac agtcctagtg gcatgcagac acgctgtgtc tggtctcctt tggcttctcc   6660

gtctacgagc attttaaaga gaggactaaa aagatcccaa gaagatgaaa tctcatcacc   6720

tgttaataag gttcgccgtg tctcctttgc agatccaata taccaagcag gattggcaga   6780

tgacattgat agacggtgct ctattgttag gtcccattct tccaatagtt ctcccatagg   6840

aaaaagtgtt aaaacttctc ctactacaca atctaagcat aataccactt cagccaaagg   6900

atttctgtcc ccaggatcac gtagccctaa atttaagagc tcaaagaagt gtttaatttc   6960

agaaatggcc aaagaatcca taccatgccc aacagaaagt gtttacccac cattggtgaa   7020

ctgtgtggca ccagttgaca tcattttacc tcagattaca tcaaacatgt gggcaagagg   7080

cctgggacaa ctcattagag ctaagaatat aaaaactatt ggtgatttga gtactcttac   7140

agcatctgaa ataaaaactc ttcctatccg ttctccaaaa gtgtccaatg taaaaaaggc   7200

tctcagaata tatcatgagc agcaggtgaa gactcgtgga ctagaagaga ttccagtttt   7260

tgatatttct gaaaaaacag taaatggaat agaaaataaa tctttgtcac ctgatgaaga   7320

aagacttgtc tcagatataa ttgatcctgt tgctttagaa attccattat ccaaaaacct   7380

tctggcacag attagtgctc ttgctcttca gctggattca gaagatcttc ataattattc   7440

aggaagccaa ctatttgaaa tgcacgagaa actaagttgt atggcaaact ctgtaataaa   7500

aaatctacag tcacgttgga gatcaccatc ccatgaaaat tctatttagt attttcagag   7560

aaaattgaag gtttttttaa acatcactgg atttcttgat tgaggaaaca agttctgaaa   7620

taatagcaca atttcaaaga agagactctt tgcaaagttg ataacatttc aaaccctgaa   7680

ggacagtgac ttattatgta agttcaattt tgtaagttca ttatgtaaga tccttttttt   7740

tttcataata tgtattcttg gctgctatgc gtggtttttc aggaaattta attatcttac   7800

tgagatgtga aagcaaaact agtaacagaa cttacatttt atttcatgct ttcttaaacc   7860

cgtgcatatt ctggtgaaac atgtaaaata ctttaagtaa aattgaacat ttttatttga   7920

atttttgctg aactgataaa ggtgtttata tttttgtttg tttgtttgtt taattcatgt   7980

ttgttgggac tgaggtttag gaagtttgtt actggttaaa aacctcaaat gaaatgcgaa   8040

agaatttgaa tttttcctgc atatgtcaac tttggacagc tttcaagaaa aatgagaaaa   8100

gtttcaactt ctggcggtta aaatattaat gcagaattta ctaagatttt attcatttgc   8160

attagcaaat attcatgcag cagcagttga ct                                 8192


<210>  4440
<211>  2472
<212>  PRT
<213>  Homosapiens

<400>  4440

Met Thr Ala Arg Gly Gln Ser Pro Leu Ala Pro Leu Leu Glu Thr Leu 
1               5                   10                  15      


Glu Asp Pro Ser Ala Ser His Gly Gly Gln Thr Asp Ala Tyr Leu Thr 
            20                  25                  30          


Leu Thr Ser Arg Met Thr Gly Glu Glu Gly Lys Glu Val Ile Thr Glu 
        35                  40                  45              


Ile Glu Lys Lys Leu Pro Arg Leu Tyr Lys Val Leu Lys Thr His Ile 
    50                  55                  60                  


Ser Ser Gln Asn Ser Glu Leu Ser Ser Ala Ala Leu Gln Ala Leu Gly 
65                  70                  75                  80  


Phe Cys Leu Tyr Asn Pro Lys Ile Thr Ser Glu Leu Ser Glu Ala Asn 
                85                  90                  95      


Ala Leu Glu Leu Leu Ser Lys Leu Asn Asp Thr Ile Lys Asn Ser Asp 
            100                 105                 110         


Lys Asn Val Arg Thr Arg Ala Leu Trp Val Ile Ser Lys Gln Thr Phe 
        115                 120                 125             


Pro Ser Glu Val Val Gly Lys Met Val Ser Ser Ile Ile Asp Ser Leu 
    130                 135                 140                 


Glu Ile Leu Phe Asn Lys Gly Glu Thr His Ser Ala Val Val Asp Phe 
145                 150                 155                 160 


Glu Ala Leu Asn Val Ile Val Arg Leu Ile Glu Gln Ala Pro Ile Gln 
                165                 170                 175     


Met Gly Glu Glu Ala Val Arg Trp Ala Lys Leu Val Ile Pro Leu Val 
            180                 185                 190         


Val His Ser Ala Gln Lys Val His Leu Arg Gly Ala Thr Ala Leu Glu 
        195                 200                 205             


Met Gly Met Pro Leu Leu Leu Gln Lys Gln Gln Glu Ile Ala Ser Ile 
    210                 215                 220                 


Thr Glu Gln Leu Met Thr Thr Lys Leu Ile Ser Glu Leu Gln Lys Leu 
225                 230                 235                 240 


Phe Met Ser Lys Asn Glu Thr Tyr Val Leu Lys Leu Trp Pro Leu Phe 
                245                 250                 255     


Val Lys Leu Leu Gly Arg Thr Leu His Arg Ser Gly Ser Phe Ile Asn 
            260                 265                 270         


Ser Leu Leu Gln Leu Glu Glu Leu Gly Phe Arg Ser Gly Ala Pro Met 
        275                 280                 285             


Ile Lys Lys Ile Ala Phe Ile Ala Trp Lys Ser Leu Ile Asp Asn Phe 
    290                 295                 300                 


Ala Leu Asn Pro Asp Ile Leu Cys Ser Ala Lys Arg Leu Lys Leu Leu 
305                 310                 315                 320 


Met Gln Pro Leu Ser Ser Ile His Val Arg Thr Glu Thr Leu Ala Leu 
                325                 330                 335     


Thr Lys Leu Glu Val Trp Trp Tyr Leu Leu Met Arg Leu Gly Pro His 
            340                 345                 350         


Leu Pro Ala Asn Phe Glu Gln Val Cys Val Pro Leu Ile Gln Ser Thr 
        355                 360                 365             


Ile Ser Ile Asp Ser Asn Ala Ser Pro Gln Gly Asn Ser Cys His Val 
    370                 375                 380                 


Ala Thr Ser Pro Gly Leu Asn Pro Met Thr Pro Val His Lys Gly Ala 
385                 390                 395                 400 


Ser Ser Pro Tyr Gly Ala Pro Gly Thr Pro Arg Met Asn Leu Ser Ser 
                405                 410                 415     


Asn Leu Gly Gly Met Ala Thr Ile Pro Ser Ile Gln Leu Leu Gly Leu 
            420                 425                 430         


Glu Met Leu Leu His Phe Leu Leu Gly Pro Glu Ala Leu Ser Phe Ala 
        435                 440                 445             


Lys Gln Asn Lys Leu Val Leu Ser Leu Glu Pro Leu Glu His Pro Leu 
    450                 455                 460                 


Ile Ser Ser Pro Ser Phe Phe Ser Lys His Ala Asn Thr Leu Ile Thr 
465                 470                 475                 480 


Ala Val His Asp Ser Phe Val Ala Val Gly Lys Asp Ala Pro Asp Val 
                485                 490                 495     


Val Val Ser Ala Ile Trp Lys Glu Leu Ile Ser Leu Val Lys Ser Val 
            500                 505                 510         


Thr Glu Ser Gly Asn Lys Lys Glu Lys Pro Gly Ser Glu Val Leu Thr 
        515                 520                 525             


Leu Leu Leu Lys Ser Leu Glu Ser Ile Val Lys Ser Glu Val Phe Pro 
    530                 535                 540                 


Val Ser Lys Thr Leu Val Leu Met Glu Ile Thr Ile Lys Gly Leu Pro 
545                 550                 555                 560 


Gln Lys Val Leu Gly Ser Pro Ala Tyr Gln Val Ala Asn Met Asp Ile 
                565                 570                 575     


Leu Asn Gly Thr Pro Ala Leu Phe Leu Ile Gln Leu Ile Phe Asn Asn 
            580                 585                 590         


Phe Leu Glu Cys Gly Val Ser Asp Glu Arg Phe Phe Leu Ser Leu Glu 
        595                 600                 605             


Ser Leu Val Gly Cys Val Leu Ser Gly Pro Thr Ser Pro Leu Ala Phe 
    610                 615                 620                 


Ser Asp Ser Val Leu Asn Val Ile Asn Gln Asn Ala Lys Gln Leu Glu 
625                 630                 635                 640 


Asn Lys Glu His Leu Trp Lys Met Trp Ser Val Ile Val Thr Pro Leu 
                645                 650                 655     


Thr Glu Leu Ile Asn Gln Thr Asn Glu Val Asn Gln Gly Asp Ala Leu 
            660                 665                 670         


Glu His Asn Phe Ser Ala Ile Tyr Gly Ala Leu Thr Leu Pro Val Asn 
        675                 680                 685             


His Ile Phe Ser Glu Gln Arg Phe Pro Val Ala Thr Met Lys Thr Leu 
    690                 695                 700                 


Leu Arg Thr Trp Ser Glu Leu Tyr Arg Ala Phe Ala Arg Cys Ala Ala 
705                 710                 715                 720 


Leu Val Ala Thr Ala Glu Glu Asn Leu Cys Cys Glu Glu Leu Ser Ser 
                725                 730                 735     


Lys Ile Met Ser Ser Leu Glu Asp Glu Gly Phe Ser Asn Leu Leu Phe 
            740                 745                 750         


Val Asp Arg Ile Ile Tyr Ile Ile Thr Val Met Val Asp Cys Ile Asp 
        755                 760                 765             


Phe Ser Pro Tyr Asn Ile Lys Tyr Gln Pro Lys Val Lys Ser Pro Gln 
    770                 775                 780                 


Arg Pro Ser Asp Trp Ser Lys Lys Lys Asn Glu Pro Leu Gly Lys Leu 
785                 790                 795                 800 


Thr Ser Leu Phe Lys Leu Ile Val Lys Val Ile Tyr Ser Phe His Thr 
                805                 810                 815     


Leu Ser Phe Lys Glu Ala His Ser Asp Thr Leu Phe Thr Ile Gly Asn 
            820                 825                 830         


Ser Ile Thr Gly Ile Ile Ser Ser Val Leu Gly His Ile Ser Leu Pro 
        835                 840                 845             


Ser Met Ile Arg Lys Ile Phe Ala Thr Leu Thr Arg Pro Leu Ala Leu 
    850                 855                 860                 


Phe Tyr Glu Asn Ser Lys Leu Asp Glu Val Pro Lys Val Tyr Ser Cys 
865                 870                 875                 880 


Leu Asn Asn Lys Leu Glu Lys Leu Leu Gly Glu Ile Ile Ala Cys Leu 
                885                 890                 895     


Gln Phe Ser Tyr Thr Gly Thr Tyr Asp Ser Glu Leu Leu Glu Gln Leu 
            900                 905                 910         


Ser Pro Leu Leu Cys Ile Ile Phe Leu His Lys Asn Lys Gln Ile Arg 
        915                 920                 925             


Lys Gln Ser Ala Gln Phe Trp Asn Ala Thr Phe Ala Lys Val Met Met 
    930                 935                 940                 


Leu Val Tyr Pro Glu Glu Leu Lys Pro Val Leu Thr Gln Ala Lys Gln 
945                 950                 955                 960 


Lys Phe Leu Leu Leu Leu Pro Gly Leu Glu Thr Val Glu Met Met Glu 
                965                 970                 975     


Glu Ser Ser Gly Pro Tyr Ser Asp Gly Thr Glu Asn Ser Gln Leu Asn 
            980                 985                 990         


Val Lys Ile Ser Gly Met Glu Arg  Lys Ser Asn Gly Lys  Arg Asp Ser 
        995                 1000                 1005             


Phe Leu  Ala Gln Thr Lys Asn  Lys Lys Glu Asn Met  Lys Pro Ala 
    1010                 1015                 1020             


Ala Lys  Leu Lys Leu Glu Ser  Ser Ser Leu Lys Val  Lys Gly Glu 
    1025                 1030                 1035             


Ile Leu  Leu Glu Glu Glu Lys  Ser Thr Asp Phe Val  Phe Ile Pro 
    1040                 1045                 1050             


Pro Glu  Gly Lys Asp Ala Lys  Glu Arg Ile Leu Thr  Asp His Gln 
    1055                 1060                 1065             


Lys Glu  Val Leu Lys Thr Lys  Arg Cys Asp Ile Pro  Ala Met Tyr 
    1070                 1075                 1080             


Asn Asn  Leu Asp Val Ser Gln  Asp Thr Leu Phe Thr  Gln Tyr Ser 
    1085                 1090                 1095             


Gln Glu  Glu Pro Met Glu Ile  Pro Thr Leu Thr Arg  Lys Pro Lys 
    1100                 1105                 1110             


Glu Asp  Ser Lys Met Met Ile  Thr Glu Glu Gln Met  Asp Ser Asp 
    1115                 1120                 1125             


Ile Val  Ile Pro Gln Asp Val  Thr Glu Asp Cys Gly  Met Ala Glu 
    1130                 1135                 1140             


His Leu  Glu Lys Ser Ser Leu  Ser Asn Asn Glu Cys  Gly Ser Leu 
    1145                 1150                 1155             


Asp Lys  Thr Ser Pro Glu Met  Ser Asn Ser Asn Asn  Asp Glu Arg 
    1160                 1165                 1170             


Lys Lys  Ala Leu Ile Ser Ser  Arg Lys Thr Ser Thr  Glu Cys Ala 
    1175                 1180                 1185             


Ser Ser  Thr Glu Asn Ser Phe  Val Val Ser Ser Ser  Ser Val Ser 
    1190                 1195                 1200             


Asn Thr  Thr Val Ala Gly Thr  Pro Pro Tyr Pro Thr  Ser Arg Arg 
    1205                 1210                 1215             


Gln Thr  Phe Ile Thr Leu Glu  Lys Phe Asp Gly Ser  Glu Asn Arg 
    1220                 1225                 1230             


Pro Phe  Ser Pro Ser Pro Leu  Asn Asn Ile Ser Ser  Thr Val Thr 
    1235                 1240                 1245             


Val Lys  Asn Asn Gln Glu Thr  Met Ile Lys Thr Asp  Phe Leu Pro 
    1250                 1255                 1260             


Lys Ala  Lys Gln Arg Glu Gly  Thr Phe Ser Lys Ser  Asp Ser Glu 
    1265                 1270                 1275             


Lys Ile  Val Asn Gly Thr Lys  Arg Ser Ser Arg Arg  Ala Gly Lys 
    1280                 1285                 1290             


Ala Glu  Gln Thr Gly Asn Lys  Arg Ser Lys Pro Leu  Met Arg Ser 
    1295                 1300                 1305             


Glu Pro  Glu Lys Asn Thr Glu  Glu Ser Val Glu Gly  Ile Val Val 
    1310                 1315                 1320             


Leu Glu  Asn Asn Pro Pro Gly  Leu Leu Asn Gln Thr  Glu Cys Val 
    1325                 1330                 1335             


Ser Asp  Asn Gln Val His Leu  Ser Glu Ser Thr Met  Glu His Asp 
    1340                 1345                 1350             


Asn Thr  Lys Leu Lys Ala Ala  Thr Val Glu Asn Ala  Val Leu Leu 
    1355                 1360                 1365             


Glu Thr  Asn Thr Val Glu Glu  Lys Asn Val Glu Ile  Asn Leu Glu 
    1370                 1375                 1380             


Ser Lys  Glu Asn Thr Pro Pro  Val Val Ile Ser Ala  Asp Gln Met 
    1385                 1390                 1395             


Val Asn  Glu Asp Ser Gln Val  Gln Ile Thr Pro Asn  Gln Lys Thr 
    1400                 1405                 1410             


Leu Arg  Arg Ser Ser Arg Arg  Arg Ser Glu Val Val  Glu Ser Thr 
    1415                 1420                 1425             


Thr Glu  Ser Gln Asp Lys Glu  Asn Ser His Gln Lys  Lys Glu Arg 
    1430                 1435                 1440             


Arg Lys  Glu Glu Glu Lys Pro  Leu Gln Lys Ser Pro  Leu His Ile 
    1445                 1450                 1455             


Lys Asp  Asp Val Leu Pro Lys  Gln Lys Leu Ile Ala  Glu Gln Thr 
    1460                 1465                 1470             


Leu Gln  Glu Asn Leu Ile Glu  Lys Gly Ser Asn Leu  His Glu Lys 
    1475                 1480                 1485             


Thr Leu  Gly Glu Thr Ser Ala  Asn Ala Glu Thr Glu  Gln Asn Lys 
    1490                 1495                 1500             


Lys Lys  Ala Asp Pro Glu Asn  Ile Lys Ser Glu Gly  Asp Gly Thr 
    1505                 1510                 1515             


Gln Asp  Ile Val Asp Lys Ser  Ser Glu Lys Leu Val  Arg Gly Arg 
    1520                 1525                 1530             


Thr Arg  Tyr Gln Thr Arg Arg  Ala Ser Gln Gly Leu  Leu Ser Ser 
    1535                 1540                 1545             


Ile Glu  Asn Ser Glu Ser Asp  Ser Ser Glu Ala Lys  Glu Glu Gly 
    1550                 1555                 1560             


Ser Arg  Lys Lys Arg Ser Gly  Lys Trp Lys Asn Lys  Ser Asn Glu 
    1565                 1570                 1575             


Ser Val  Asp Ile Gln Asp Gln  Glu Glu Lys Val Val  Lys Gln Glu 
    1580                 1585                 1590             


Cys Ile  Lys Ala Glu Asn Gln  Ser His Asp Tyr Lys  Ala Thr Ser 
    1595                 1600                 1605             


Glu Glu  Asp Val Ser Ile Lys  Ser Pro Ile Cys Glu  Lys Gln Asp 
    1610                 1615                 1620             


Glu Ser  Asn Thr Val Ile Cys  Gln Asp Ser Thr Val  Thr Ser Asp 
    1625                 1630                 1635             


Leu Leu  Gln Val Pro Asp Asp  Leu Pro Asn Val Cys  Glu Glu Lys 
    1640                 1645                 1650             


Asn Glu  Thr Ser Lys Tyr Ala  Glu Tyr Ser Phe Thr  Ser Leu Pro 
    1655                 1660                 1665             


Val Pro  Glu Ser Asn Leu Arg  Thr Arg Asn Ala Ile  Lys Arg Leu 
    1670                 1675                 1680             


His Lys  Arg Asp Ser Phe Asp  Asn Cys Ser Leu Gly  Glu Ser Ser 
    1685                 1690                 1695             


Lys Ile  Gly Ile Ser Asp Ile  Ser Ser Leu Ser Glu  Lys Thr Phe 
    1700                 1705                 1710             


Gln Thr  Leu Glu Cys Gln His  Lys Arg Ser Arg Arg  Val Arg Arg 
    1715                 1720                 1725             


Ser Lys  Gly Cys Asp Cys Cys  Gly Glu Lys Ser Gln  Pro Gln Glu 
    1730                 1735                 1740             


Lys Ser  Leu Ile Gly Leu Lys  Asn Thr Glu Asn Asn  Asp Val Glu 
    1745                 1750                 1755             


Ile Ser  Glu Thr Lys Lys Ala  Asp Val Gln Ala Pro  Val Ser Pro 
    1760                 1765                 1770             


Ser Glu  Thr Ser Gln Ala Asn  Pro Tyr Ser Glu Gly  Gln Phe Leu 
    1775                 1780                 1785             


Asp Glu  His His Ser Val Asn  Phe His Leu Gly Leu  Lys Glu Asp 
    1790                 1795                 1800             


Asn Asp  Thr Ile Asn Asp Ser  Leu Ile Val Ser Glu  Thr Lys Ser 
    1805                 1810                 1815             


Lys Glu  Asn Thr Met Gln Glu  Ser Leu Pro Ser Gly  Ile Val Asn 
    1820                 1825                 1830             


Phe Arg  Glu Glu Ile Cys Asp  Met Asp Ser Ser Glu  Ala Met Ser 
    1835                 1840                 1845             


Leu Glu  Ser Gln Glu Ser Pro  Asn Glu Asn Phe Lys  Thr Val Gly 
    1850                 1855                 1860             


Pro Cys  Leu Gly Asp Ser Lys  Asn Val Ser Gln Glu  Ser Leu Glu 
    1865                 1870                 1875             


Thr Lys  Glu Glu Lys Pro Glu  Glu Thr Pro Lys Met  Glu Leu Ser 
    1880                 1885                 1890             


Leu Glu  Asn Val Thr Val Glu  Gly Asn Ala Cys Lys  Val Thr Glu 
    1895                 1900                 1905             


Ser Asn  Leu Glu Lys Ala Lys  Thr Met Glu Leu Asn  Val Gly Asn 
    1910                 1915                 1920             


Glu Ala  Ser Phe His Gly Gln  Glu Arg Thr Lys Thr  Gly Ile Ser 
    1925                 1930                 1935             


Glu Glu  Ala Ala Ile Glu Glu  Asn Lys Arg Asn Asp  Asp Ser Glu 
    1940                 1945                 1950             


Ala Asp  Thr Ala Lys Leu Asn  Ala Lys Glu Val Ala  Thr Glu Glu 
    1955                 1960                 1965             


Phe Asn  Ser Asp Ile Ser Leu  Ser Asp Asn Thr Thr  Pro Val Lys 
    1970                 1975                 1980             


Leu Asn  Ala Gln Thr Glu Ile  Ser Glu Gln Thr Ala  Ala Gly Glu 
    1985                 1990                 1995             


Leu Asp  Gly Gly Asn Asp Val  Ser Asp Leu His Ser  Ser Glu Glu 
    2000                 2005                 2010             


Thr Asn  Thr Lys Met Lys Asn  Asn Glu Glu Met Met  Ile Gly Glu 
    2015                 2020                 2025             


Ala Met  Ala Glu Thr Gly His  Asp Gly Glu Thr Glu  Asn Glu Gly 
    2030                 2035                 2040             


Ile Thr  Thr Lys Thr Ser Lys  Pro Asp Glu Ala Glu  Thr Asn Met 
    2045                 2050                 2055             


Leu Thr  Ala Glu Met Asp Asn  Phe Val Cys Asp Thr  Val Glu Met 
    2060                 2065                 2070             


Ser Thr  Glu Glu Gly Ile Ile  Asp Ala Asn Lys Thr  Glu Thr Asn 
    2075                 2080                 2085             


Thr Glu  Tyr Ser Lys Ser Glu  Glu Lys Leu Asp Asn  Asn Gln Met 
    2090                 2095                 2100             


Val Met  Glu Ser Asp Ile Leu  Gln Glu Asp His His  Thr Ser Gln 
    2105                 2110                 2115             


Lys Val  Glu Glu Pro Ser Gln  Cys Leu Ala Ser Gly  Thr Ala Ile 
    2120                 2125                 2130             


Ser Glu  Leu Ile Ile Glu Asp  Asn Asn Ala Ser Pro  Gln Lys Leu 
    2135                 2140                 2145             


Arg Glu  Leu Asp Pro Ser Leu  Val Ser Ala Asn Asp  Ser Pro Ser 
    2150                 2155                 2160             


Gly Met  Gln Thr Arg Cys Val  Trp Ser Pro Leu Ala  Ser Pro Ser 
    2165                 2170                 2175             


Thr Ser  Ile Leu Lys Arg Gly  Leu Lys Arg Ser Gln  Glu Asp Glu 
    2180                 2185                 2190             


Ile Ser  Ser Pro Val Asn Lys  Val Arg Arg Val Ser  Phe Ala Asp 
    2195                 2200                 2205             


Pro Ile  Tyr Gln Ala Gly Leu  Ala Asp Asp Ile Asp  Arg Arg Cys 
    2210                 2215                 2220             


Ser Ile  Val Arg Ser His Ser  Ser Asn Ser Ser Pro  Ile Gly Lys 
    2225                 2230                 2235             


Ser Val  Lys Thr Ser Pro Thr  Thr Gln Ser Lys His  Asn Thr Thr 
    2240                 2245                 2250             


Ser Ala  Lys Gly Phe Leu Ser  Pro Gly Ser Arg Ser  Pro Lys Phe 
    2255                 2260                 2265             


Lys Ser  Ser Lys Lys Cys Leu  Ile Ser Glu Met Ala  Lys Glu Ser 
    2270                 2275                 2280             


Ile Pro  Cys Pro Thr Glu Ser  Val Tyr Pro Pro Leu  Val Asn Cys 
    2285                 2290                 2295             


Val Ala  Pro Val Asp Ile Ile  Leu Pro Gln Ile Thr  Ser Asn Met 
    2300                 2305                 2310             


Trp Ala  Arg Gly Leu Gly Gln  Leu Ile Arg Ala Lys  Asn Ile Lys 
    2315                 2320                 2325             


Thr Ile  Gly Asp Leu Ser Thr  Leu Thr Ala Ser Glu  Ile Lys Thr 
    2330                 2335                 2340             


Leu Pro  Ile Arg Ser Pro Lys  Val Ser Asn Val Lys  Lys Ala Leu 
    2345                 2350                 2355             


Arg Ile  Tyr His Glu Gln Gln  Val Lys Thr Arg Gly  Leu Glu Glu 
    2360                 2365                 2370             


Ile Pro  Val Phe Asp Ile Ser  Glu Lys Thr Val Asn  Gly Ile Glu 
    2375                 2380                 2385             


Asn Lys  Ser Leu Ser Pro Asp  Glu Glu Arg Leu Val  Ser Asp Ile 
    2390                 2395                 2400             


Ile Asp  Pro Val Ala Leu Glu  Ile Pro Leu Ser Lys  Asn Leu Leu 
    2405                 2410                 2415             


Ala Gln  Ile Ser Ala Leu Ala  Leu Gln Leu Asp Ser  Glu Asp Leu 
    2420                 2425                 2430             


His Asn  Tyr Ser Gly Ser Gln  Leu Phe Glu Met His  Glu Lys Leu 
    2435                 2440                 2445             


Ser Cys  Met Ala Asn Ser Val  Ile Lys Asn Leu Gln  Ser Arg Trp 
    2450                 2455                 2460             


Arg Ser  Pro Ser His Glu Asn  Ser Ile 
    2465                 2470         


<210>  4441
<211>  1744
<212>  DNA
<213>  Homosapiens

<400>  4441
atgcaggaaa ctattatagc tggcctaact taccaatacc acctaaatac tgggagggag     60

ccgcgaaaga gaacgggggc tggggggagg ggtagcgaca agaagattaa aagagggaag    120

cagaggagtt gggagctggc ggtcgttccc ggggaagaac tgctaaaaca tgagaccaag    180

gcacagacct tactgtatga gaagcaatgc tcctcaaacc ttctgcgtgc tgacatagac    240

cttcccagaa gcaaaactgt tggcggcgac ctgagcgctg gaagccgaag gggaagagga    300

aggagacgcg aagccagggc ggccggcaca aaggcggcgg actcgcggcg gcagcgcctg    360

cccggccggg agcacaaccc acggccctac tccagcgaag tcccgcaccg gcttctagga    420

ataaagttta cgttctcctg aggccgcacc ccccacctcc cacccaggac ggcacatctc    480

cgtgtcctcc tcccccaaac tccactcggg accccgagaa ccaccccagc cttccggcca    540

ccacaacaaa gagccgcacc gaccggcgag gataaacagc ggcggagggc gagagggcgg    600

cggggcgagc gcctccacgc agcaactccg gagtcccccg cttgcccgag cgcagtttct    660

ccgctgctgt ttccaccggc tttgtaacac tgggaattta catcctcacc cgcacccctc    720

acgcccgagg attttaaact cacctttact ctcgaactga gagttgcggt agatgggatt    780

tttgcctttt ccccagatgg ttgaaggtta agatttttgg aaaccccacc acctccttat    840

ttctattatt atttctgcaa gaaaagtata aagagagttg tagtggaggt gagatttgtg    900

atcgggaaag ccttcgactc cctccttctc cgtcttccgc ctctctctct ctgattagtt    960

cctatccagc agcagattga agcaggagat gattcttctc aaggtttgtt cagcagcttc   1020

acttctaggc gaaggcttca tgaaccaagt gacgtcaacc aacaaggctt ctctctctct   1080

cctctctcta acaatgaaag ttgctgttaa caagggaaaa aaagagagag aattgtttat   1140

accatttcag ttccaataat aaatgaccta tcagctccta aaggagccaa gggagggggt   1200

tgcttcttct ttccaagaat actgtagctt tgagtttgca ccgttccttg tcccaggaaa   1260

aagttaagaa acttaaaatg ttttgttttg cttttaaaga agacaggaca gaaaacggga   1320

tttaaaactt agtttttaaa aaaacaaaag ctacagagta gggagcatag gtcaaccatc   1380

tccacctaaa ttttttttgt tcctaaactc agaattctac aacccaacta aattaatatg   1440

ccaagatttt gcggatgtta aaactcaaaa aaagcagtat gcaagacggt cccggggtaa   1500

aattctactg cctttccacg gacaagttaa actggctgta atgtttatgc actaagttaa   1560

aataaaattt aaataaaaga cgttaaaata gtcgttttaa agttatatgc acacactgta   1620

aaaggtaatc tcgatagctt tttttcaagt ttctgagaga ttagaaaaaa agcatagcaa   1680

attgtaggca ctgaacactt tttaaaaatc aagttatgag taagactggt agccctttgc   1740

tcct                                                                1744


<210>  4442
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  4442

Met Gln Glu Thr Ile Ile Ala Gly Leu Thr Tyr Gln Tyr His Leu Asn 
1               5                   10                  15      


Thr Gly Arg Glu Pro Arg Lys Arg Thr Gly Ala Gly Gly Arg Gly Ser 
            20                  25                  30          


Asp Lys Lys Ile Lys Arg Gly Lys Gln Arg Ser Trp Glu Leu Ala Val 
        35                  40                  45              


Val Pro Gly Glu Glu Leu Leu Lys His Glu Thr Lys Ala Gln Thr Leu 
    50                  55                  60                  


Leu Tyr Glu Lys Gln Cys Ser Ser Asn Leu Leu Arg Ala Asp Ile Asp 
65                  70                  75                  80  


Leu Pro Arg Ser Lys Thr Val Gly Gly Asp Leu Ser Ala Gly Ser Arg 
                85                  90                  95      


Arg Gly Arg Gly Arg Arg Arg Glu Ala Arg Ala Ala Gly Thr Lys Ala 
            100                 105                 110         


Ala Asp Ser Arg Arg Gln Arg Leu Pro Gly Arg Glu His Asn Pro Arg 
        115                 120                 125             


Pro Tyr Ser Ser Glu Val Pro His Arg Leu Leu Gly Ile Lys Phe Thr 
    130                 135                 140                 


Phe Ser 
145     


<210>  4443
<211>  1744
<212>  DNA
<213>  Homosapiens

<400>  4443
atgcaggaaa ctattatagc tggcctaact taccaatacc acctaaatac tgggagggag     60

ccgcgaaaga gaacgggggc gggggggagg ggtagcgaca agaagattaa aagagggaag    120

cagaggagtt gggagctggc ggtcgttccc ggggaagaac tgctaaaaca tgagaccaag    180

gcacagacct tactgtatga gaagcaatgc tcctcaaacc ttctgcgtgc tgacatagac    240

cttcccagaa gcaaaactgt tggcggcgac ctgagcgctg gaagccgaag gggaagagga    300

aggagacgcg aagccagggc ggccggcaca aaggcggcgg actcgcggcg gcagcgcctg    360

cccggccggg agcacaaccc acggccctac tccagcgaag tcccgcaccg gcttctagga    420

ataaagttta cgttctcctg aggccgcacc ccccacctcc cacccaggac ggcacatctc    480

cgtgtcctcc tcccccaaac tccactcggg accccgagaa ccaccccagc cttccggcca    540

ccacaacaaa gagccgcacc gaccggcgag gataaacagc ggcggagggc gagagggcgg    600

cggggcgagc gcctccacgc agcaactccg gagtcccccg cttgcccgag cgcagtttct    660

ccgctgctgt ttccaccggc tttgtaacac tgggaattta catcctcacc cgcacccctc    720

acgcccgagg attttaaact cacctttact ctcgaactga gagttgcggt agatgggatt    780

tttgcctttt ccccagatgg ttgaaggtta agatttttgg aaaccccacc acctccttat    840

ttctattatt atttctgcaa gaaaagtata aagagagttg tagtggaggt gagatttgtg    900

atcgggaaag ccttcgactc cctccttctc cgtcttccgc ctctctctct ctgattagtt    960

cctatccagc agcagattga agcaggagat gattcttctc aaggtttgtt cagcagcttc   1020

acttctaggc gaaggcttca tgaaccaagt gacgtcaacc aacaaggctt ctctctctct   1080

cctctctcta acaatgaaag ttgctgttaa caagggaaaa aaagagagag aattgtttat   1140

accatttcag ttccaataat aaatgaccta tcagctccta aaggagccaa gggagggggt   1200

tgcttcttct ttccaagaat actgtagctt tgagtttgca ccgttccttg tcccaggaaa   1260

aagttaagaa acttaaaatg ttttgttttg cttttaaaga agacaggaca gaaaacggga   1320

tttaaaactt agtttttaaa aaaacaaaag ctacagagta gggagcatag gtcaaccatc   1380

tccacctaaa ttttttttgt tcctaaactc agaattctac aacccaacta aattaatatg   1440

ccaagatttt gcggatgtta aaactcaaaa aaagcagtat gcaagacggt cccggggtaa   1500

aattctactg cctttccacg gacaagttaa actggctgta atgtttatgc actaagttaa   1560

aataaaattt aaataaaaga cgttaaaata gtcgttttaa agttatatgc acacactgta   1620

aaaggtaatc tcgatagctt tttttcaagt ttctgagaga ttagaaaaaa agcatagcaa   1680

attgtaggca ctgaacactt tttaaaaatc aagttatgag taagactggt agccctttgc   1740

tcct                                                                1744


<210>  4444
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  4444

Met Gln Glu Thr Ile Ile Ala Gly Leu Thr Tyr Gln Tyr His Leu Asn 
1               5                   10                  15      


Thr Gly Arg Glu Pro Arg Lys Arg Thr Gly Ala Gly Gly Arg Gly Ser 
            20                  25                  30          


Asp Lys Lys Ile Lys Arg Gly Lys Gln Arg Ser Trp Glu Leu Ala Val 
        35                  40                  45              


Val Pro Gly Glu Glu Leu Leu Lys His Glu Thr Lys Ala Gln Thr Leu 
    50                  55                  60                  


Leu Tyr Glu Lys Gln Cys Ser Ser Asn Leu Leu Arg Ala Asp Ile Asp 
65                  70                  75                  80  


Leu Pro Arg Ser Lys Thr Val Gly Gly Asp Leu Ser Ala Gly Ser Arg 
                85                  90                  95      


Arg Gly Arg Gly Arg Arg Arg Glu Ala Arg Ala Ala Gly Thr Lys Ala 
            100                 105                 110         


Ala Asp Ser Arg Arg Gln Arg Leu Pro Gly Arg Glu His Asn Pro Arg 
        115                 120                 125             


Pro Tyr Ser Ser Glu Val Pro His Arg Leu Leu Gly Ile Lys Phe Thr 
    130                 135                 140                 


Phe Ser 
145     


<210>  4445
<211>  381
<212>  DNA
<213>  Homosapiens

<400>  4445
atggtcctgg ggatgctggt gtctgagatc atgactatgc ctgtgctgag tatgtactgt     60

gggatgctga agttttatgt gtatgtaagc ctggatccag ccatggccaa cgatttcctc    120

atattttcct atgaccttag gaacatcaga tatgggtaca tccagcaaaa ccaaccagag    180

aacatggaga tactcatctc taccgctggt gctgggttcc cctctcatcg gtctggctgc    240

cactgttggg aggtggaagt gggaggccca gctgaacggg ctctgggtgt gtgcagagaa    300

tctgcatatt gcaaagggac tttccctgta tctttagact ttgggttctg gattgtgggc    360

tcaggggagg acatgaagta g                                              381


<210>  4446
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  4446

Met Val Leu Gly Met Leu Val Ser Glu Ile Met Thr Met Pro Val Leu 
1               5                   10                  15      


Ser Met Tyr Cys Gly Met Leu Lys Phe Tyr Val Tyr Val Ser Leu Asp 
            20                  25                  30          


Pro Ala Met Ala Asn Asp Phe Leu Ile Phe Ser Tyr Asp Leu Arg Asn 
        35                  40                  45              


Ile Arg Tyr Gly Tyr Ile Gln Gln Asn Gln Pro Glu Asn Met Glu Ile 
    50                  55                  60                  


Leu Ile Ser Thr Ala Gly Ala Gly Phe Pro Ser His Arg Ser Gly Cys 
65                  70                  75                  80  


His Cys Trp Glu Val Glu Val Gly Gly Pro Ala Glu Arg Ala Leu Gly 
                85                  90                  95      


Val Cys Arg Glu Ser Ala Tyr Cys Lys Gly Thr Phe Pro Val Ser Leu 
            100                 105                 110         


Asp Phe Gly Phe Trp Ile Val Gly Ser Gly Glu Asp Met Lys 
        115                 120                 125     


<210>  4447
<211>  381
<212>  DNA
<213>  Homosapiens

<400>  4447
atggtcctgg ggatgctggt gtctgagatc atgactatgc ctgtgctgag tatgtactgt     60

gggatgctga agttttatgt gtatgtaagc ctggatccag ccatggccaa cgatttcctc    120

atattttcct atgaccttag gaacatcaga tatgggtaca tccagcaaaa ccaaccagag    180

aacatggaga tactcatctc taccgctggt gctgggttcc cctctcatcg gtctggctgc    240

cactgttggg aggtggaagt gggaggccca gctgaacggg ctctgggtgt gtgcagagaa    300

tctgcatatt gcaaagggac tttccctgta tctttagact ttgggttctg gattgtgggc    360

tcaggggagg acatgaagta g                                              381


<210>  4448
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  4448

Met Val Leu Gly Met Leu Val Ser Glu Ile Met Thr Met Pro Val Leu 
1               5                   10                  15      


Ser Met Tyr Cys Gly Met Leu Lys Phe Tyr Val Tyr Val Ser Leu Asp 
            20                  25                  30          


Pro Ala Met Ala Asn Asp Phe Leu Ile Phe Ser Tyr Asp Leu Arg Asn 
        35                  40                  45              


Ile Arg Tyr Gly Tyr Ile Gln Gln Asn Gln Pro Glu Asn Met Glu Ile 
    50                  55                  60                  


Leu Ile Ser Thr Ala Gly Ala Gly Phe Pro Ser His Arg Ser Gly Cys 
65                  70                  75                  80  


His Cys Trp Glu Val Glu Val Gly Gly Pro Ala Glu Arg Ala Leu Gly 
                85                  90                  95      


Val Cys Arg Glu Ser Ala Tyr Cys Lys Gly Thr Phe Pro Val Ser Leu 
            100                 105                 110         


Asp Phe Gly Phe Trp Ile Val Gly Ser Gly Glu Asp Met Lys 
        115                 120                 125     


<210>  4449
<211>  640
<212>  DNA
<213>  Homosapiens

<400>  4449
atggtcaacc ccaccgtgtt cttccacatc tctgtcgacg gtgagtcctt gggccgcatc     60

tcttttgagc tgtttgcaga caagtttcca aagacagcag aaaacttttg tgctctgaat    120

actggagaga aaggatttgg ttacaagggt tgctgctttc acagaattat tccagggttt    180

atgtgtcatg gtggtgactt cacacaccat aatggcactg gtggcaagtc aatctacggg    240

gagaaagttg atgatgacaa cttcatcctg aagcatacag gtcctggcat attgtccatg    300

gcaaatgctg gacccaacac aaatggttcc cagtttttca tctgcactgc caagtctgag    360

tggttggata gcaagcatgt ggtcattggc aaggtgaaag aaggcatgaa tattgtggag    420

gccatggagc actttgggtc caggaatggc aagaccagca agaaggtcac cattcctgac    480

tttggacaac tcgaataagt ttgacttgtg ttttatctta accactggac cattccttct    540

gcagctcagg agagcagccc tccaccccat ctgctcgcag tattctagaa tctttgtgct    600

ctcgctgcag ttccctttgg gttccatgtt ttccttgttc                          640


<210>  4450
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  4450

Met Val Asn Pro Thr Val Phe Phe His Ile Ser Val Asp Gly Glu Ser 
1               5                   10                  15      


Leu Gly Arg Ile Ser Phe Glu Leu Phe Ala Asp Lys Phe Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Cys Ala Leu Asn Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Cys Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys His Gly 
    50                  55                  60                  


Gly Asp Phe Thr His His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Val Asp Asp Asp Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Ser Glu Trp Leu Asp Ser Lys His Val Val 
        115                 120                 125             


Ile Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu His 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Val Thr Ile Pro Asp 
145                 150                 155                 160 


Phe Gly Gln Leu Glu 
                165 


<210>  4451
<211>  1077
<212>  DNA
<213>  Homosapiens

<400>  4451
atggtgcgga tcgtggctgg gtgggcgcag ggccgaggaa aacttgcttt tcgttcctct     60

gttgcgctgg aagctatggg acaggaaatg ccagggaaac cgggggactc gaaatcgcac    120

tgcccttacc gggcccgggc gagactctgg gcccccaggc cgcgtccccc gcccccaccg    180

acctccaggc cgctacccgc ctctgagctt gggcccctga ccaccgcctc cagctccttc    240

tggcccctga gccggaaagg cacaggcctc tggggccccg aggtggccct ggggaggcga    300

ggccccaccg caattgggga ccgaactcgt gttgtaactg gcgggatctc gcctcccacg    360

cgcgctgtct ccaatttggt catcaccggc cggccggtcg ccacccgctc aggtcaaggt    420

tccccgcgcc cccaggggcg cctagggctt gggggaggcc gggcaggggg cctaggccct    480

gttttcgcct gttggcttcg gccggggccc cggggccccg ctgcctctgg gctcaggttc    540

cgcggactgc tgtctcccgg ctggacgctc ggtccggggc cgccgcccgc cgctcccggg    600

agcctgggtg atggacgtcc gctgacccgc ggggcagagg cagcgcacac aggccttgat    660

cactggcctg cggagggagc cgcgcggcca gcgggacctg cacgaccggg ccctttgatc    720

tgcctttatt atcaacgaga aacaaagctc cctgggcccg acgcccgggc gcccgcgttc    780

ctggggagac ccaccacacc ctctactccg cgccgccagc ccgcggcccc caaacgcgcc    840

aggcaccctc tgggcctcca gtgccccggc ccgaagcccc tccggaaaac gcgtccctgc    900

cagccggctc tccggaagac catcccccga ccagaggcgc ttagggagtg gggggctccc    960

ggttatgaac agcttgatcg gggagagaaa atggccaaag tgaagaaaaa ctcgagtaag   1020

aagagcgggg cagcctggcc gcggggagct caagaaggag aaggaagaag ccattga      1077


<210>  4452
<211>  358
<212>  PRT
<213>  Homosapiens

<400>  4452

Met Val Arg Ile Val Ala Gly Trp Ala Gln Gly Arg Gly Lys Leu Ala 
1               5                   10                  15      


Phe Arg Ser Ser Val Ala Leu Glu Ala Met Gly Gln Glu Met Pro Gly 
            20                  25                  30          


Lys Pro Gly Asp Ser Lys Ser His Cys Pro Tyr Arg Ala Arg Ala Arg 
        35                  40                  45              


Leu Trp Ala Pro Arg Pro Arg Pro Pro Pro Pro Pro Thr Ser Arg Pro 
    50                  55                  60                  


Leu Pro Ala Ser Glu Leu Gly Pro Leu Thr Thr Ala Ser Ser Ser Phe 
65                  70                  75                  80  


Trp Pro Leu Ser Arg Lys Gly Thr Gly Leu Trp Gly Pro Glu Val Ala 
                85                  90                  95      


Leu Gly Arg Arg Gly Pro Thr Ala Ile Gly Asp Arg Thr Arg Val Val 
            100                 105                 110         


Thr Gly Gly Ile Ser Pro Pro Thr Arg Ala Val Ser Asn Leu Val Ile 
        115                 120                 125             


Thr Gly Arg Pro Val Ala Thr Arg Ser Gly Gln Gly Ser Pro Arg Pro 
    130                 135                 140                 


Gln Gly Arg Leu Gly Leu Gly Gly Gly Arg Ala Gly Gly Leu Gly Pro 
145                 150                 155                 160 


Val Phe Ala Cys Trp Leu Arg Pro Gly Pro Arg Gly Pro Ala Ala Ser 
                165                 170                 175     


Gly Leu Arg Phe Arg Gly Leu Leu Ser Pro Gly Trp Thr Leu Gly Pro 
            180                 185                 190         


Gly Pro Pro Pro Ala Ala Pro Gly Ser Leu Gly Asp Gly Arg Pro Leu 
        195                 200                 205             


Thr Arg Gly Ala Glu Ala Ala His Thr Gly Leu Asp His Trp Pro Ala 
    210                 215                 220                 


Glu Gly Ala Ala Arg Pro Ala Gly Pro Ala Arg Pro Gly Pro Leu Ile 
225                 230                 235                 240 


Cys Leu Tyr Tyr Gln Arg Glu Thr Lys Leu Pro Gly Pro Asp Ala Arg 
                245                 250                 255     


Ala Pro Ala Phe Leu Gly Arg Pro Thr Thr Pro Ser Thr Pro Arg Arg 
            260                 265                 270         


Gln Pro Ala Ala Pro Lys Arg Ala Arg His Pro Leu Gly Leu Gln Cys 
        275                 280                 285             


Pro Gly Pro Lys Pro Leu Arg Lys Thr Arg Pro Cys Gln Pro Ala Leu 
    290                 295                 300                 


Arg Lys Thr Ile Pro Arg Pro Glu Ala Leu Arg Glu Trp Gly Ala Pro 
305                 310                 315                 320 


Gly Tyr Glu Gln Leu Asp Arg Gly Glu Lys Met Ala Lys Val Lys Lys 
                325                 330                 335     


Asn Ser Ser Lys Lys Ser Gly Ala Ala Trp Pro Arg Gly Ala Gln Glu 
            340                 345                 350         


Gly Glu Gly Arg Ser His 
        355             


<210>  4453
<211>  1077
<212>  DNA
<213>  Homosapiens

<400>  4453
atggtgcgga tcgtggctgg gtgggcgcag ggccgaggaa aacttgcttt tcgttcctct     60

gttgcgctgg aagctatggg acaggaaatg ccagggaaac cgggggactc gaaatcgcac    120

tgcccttacc gggcccgggc gagactctgg gcccccaggc cgcgtccccc gcccccaccg    180

acctccaggc cgctacccgc ctctgagctt gggcccctga ccaccgcctc cagctccttc    240

tggcccctga gccggaaagg cacaggcctc tggggccccg aggtggccct ggggaggcga    300

ggccccaccg caattgggga ccgaactcgt gttgtaactg gcgggatctc gcctcccacg    360

cgcgctgtct ccaatttggt catcaccggc cggccggtcg ccacccgctc aggtcaaggt    420

tccccgcgcc cccaggggcg cctagggctt gggggaggcc gggcaggggg cctaggccct    480

gttttcgcct gttggcttcg gccggggccc cggggccccg ctgcctctgg gctcaggttc    540

cgcggactgc tgtctcccgg ctggacgctc ggtccggggc cgccgcccgc cgctcccggg    600

agcctgggtg atggacgtcc gctgacccgc ggggcagagg cagcgcacac aggccttgat    660

cactggcctg cggagggagc cgcgcggcca gcgggacctg cacgaccggg ccctttgatc    720

tgcctttatt atcaacgaga aacaaagctc cctgggcccg acgcccgggc gcccgcgttc    780

ctggggagac ccaccacacc ctctactccg cgccgccagc ccgcggcccc caaacgcgcc    840

aggcaccctc tgggcctcca gtgccccggc ccgaagcccc tccggaaaac gcgtccctgc    900

cagccggctc tccggaagac catcccccga ccagaggcgc ttagggagtg gggggctccc    960

ggttatgaac agcttgatcg gggagagaaa atggccaaag tgaagaaaaa ctcgagtaag   1020

aagagcgggg cagcctggcc gcggggagct caagaaggag aaggaagaag ccattga      1077


<210>  4454
<211>  358
<212>  PRT
<213>  Homosapiens

<400>  4454

Met Val Arg Ile Val Ala Gly Trp Ala Gln Gly Arg Gly Lys Leu Ala 
1               5                   10                  15      


Phe Arg Ser Ser Val Ala Leu Glu Ala Met Gly Gln Glu Met Pro Gly 
            20                  25                  30          


Lys Pro Gly Asp Ser Lys Ser His Cys Pro Tyr Arg Ala Arg Ala Arg 
        35                  40                  45              


Leu Trp Ala Pro Arg Pro Arg Pro Pro Pro Pro Pro Thr Ser Arg Pro 
    50                  55                  60                  


Leu Pro Ala Ser Glu Leu Gly Pro Leu Thr Thr Ala Ser Ser Ser Phe 
65                  70                  75                  80  


Trp Pro Leu Ser Arg Lys Gly Thr Gly Leu Trp Gly Pro Glu Val Ala 
                85                  90                  95      


Leu Gly Arg Arg Gly Pro Thr Ala Ile Gly Asp Arg Thr Arg Val Val 
            100                 105                 110         


Thr Gly Gly Ile Ser Pro Pro Thr Arg Ala Val Ser Asn Leu Val Ile 
        115                 120                 125             


Thr Gly Arg Pro Val Ala Thr Arg Ser Gly Gln Gly Ser Pro Arg Pro 
    130                 135                 140                 


Gln Gly Arg Leu Gly Leu Gly Gly Gly Arg Ala Gly Gly Leu Gly Pro 
145                 150                 155                 160 


Val Phe Ala Cys Trp Leu Arg Pro Gly Pro Arg Gly Pro Ala Ala Ser 
                165                 170                 175     


Gly Leu Arg Phe Arg Gly Leu Leu Ser Pro Gly Trp Thr Leu Gly Pro 
            180                 185                 190         


Gly Pro Pro Pro Ala Ala Pro Gly Ser Leu Gly Asp Gly Arg Pro Leu 
        195                 200                 205             


Thr Arg Gly Ala Glu Ala Ala His Thr Gly Leu Asp His Trp Pro Ala 
    210                 215                 220                 


Glu Gly Ala Ala Arg Pro Ala Gly Pro Ala Arg Pro Gly Pro Leu Ile 
225                 230                 235                 240 


Cys Leu Tyr Tyr Gln Arg Glu Thr Lys Leu Pro Gly Pro Asp Ala Arg 
                245                 250                 255     


Ala Pro Ala Phe Leu Gly Arg Pro Thr Thr Pro Ser Thr Pro Arg Arg 
            260                 265                 270         


Gln Pro Ala Ala Pro Lys Arg Ala Arg His Pro Leu Gly Leu Gln Cys 
        275                 280                 285             


Pro Gly Pro Lys Pro Leu Arg Lys Thr Arg Pro Cys Gln Pro Ala Leu 
    290                 295                 300                 


Arg Lys Thr Ile Pro Arg Pro Glu Ala Leu Arg Glu Trp Gly Ala Pro 
305                 310                 315                 320 


Gly Tyr Glu Gln Leu Asp Arg Gly Glu Lys Met Ala Lys Val Lys Lys 
                325                 330                 335     


Asn Ser Ser Lys Lys Ser Gly Ala Ala Trp Pro Arg Gly Ala Gln Glu 
            340                 345                 350         


Gly Glu Gly Arg Ser His 
        355             


<210>  4455
<211>  483
<212>  DNA
<213>  Homosapiens

<400>  4455
atgggatccc tgccccctac agagttggca gggtgggggt cccatgctcc caggcatacc     60

tgcagctgcc tagctgtggc tctggatcca ggcatccctg aactctcagg ggcccaggaa    120

gcccctgccc tcatagcccc agacgtccct gctcccactc cttggactct ccctgctcct    180

agtgcctgct ccgatttcag agcaaagttg tggccaatcc tgggcgctgt tgtgacccag    240

ccaggtgtgc atgtactcgg tgcagtactc acacaccagc cccctgctgt cttggccgct    300

tctggatttt gtgtgccaat gagcatgagg gggaggccag ggggccctga ggcagcttgg    360

catcggcctg caggcacctc tcaacacaaa cagcctggat gccatggaca gcatgttgat    420

ggcagggggg aagacaggtt cctgggtgga aagggccagg tccccagtaa aacctcacat    480

tga                                                                  483


<210>  4456
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  4456

Met Gly Ser Leu Pro Pro Thr Glu Leu Ala Gly Trp Gly Ser His Ala 
1               5                   10                  15      


Pro Arg His Thr Cys Ser Cys Leu Ala Val Ala Leu Asp Pro Gly Ile 
            20                  25                  30          


Pro Glu Leu Ser Gly Ala Gln Glu Ala Pro Ala Leu Ile Ala Pro Asp 
        35                  40                  45              


Val Pro Ala Pro Thr Pro Trp Thr Leu Pro Ala Pro Ser Ala Cys Ser 
    50                  55                  60                  


Asp Phe Arg Ala Lys Leu Trp Pro Ile Leu Gly Ala Val Val Thr Gln 
65                  70                  75                  80  


Pro Gly Val His Val Leu Gly Ala Val Leu Thr His Gln Pro Pro Ala 
                85                  90                  95      


Val Leu Ala Ala Ser Gly Phe Cys Val Pro Met Ser Met Arg Gly Arg 
            100                 105                 110         


Pro Gly Gly Pro Glu Ala Ala Trp His Arg Pro Ala Gly Thr Ser Gln 
        115                 120                 125             


His Lys Gln Pro Gly Cys His Gly Gln His Val Asp Gly Arg Gly Glu 
    130                 135                 140                 


Asp Arg Phe Leu Gly Gly Lys Gly Gln Val Pro Ser Lys Thr Ser His 
145                 150                 155                 160 


<210>  4457
<211>  483
<212>  DNA
<213>  Homosapiens

<400>  4457
atgggatccc tgccccctac agagttggca gggtgggggt cccatgctcc caggcatacc     60

tgcagctgcc tagctgtggc tctggatcca ggcatccctg aactctcagg ggcccaggaa    120

gcccctgccc tcatagcccc agacgtccct gctcccactc cttggactct ccctgctcct    180

agtgcctgct ccgatttcag agcaaagttg tggccaatcc tgggcgctgt tgtgacccag    240

ccaggtgtgc atgtactcgg tgcagtactc acacaccagc cccctgctgt cttggccgct    300

tctggatttt gtgtgccaat gagcatgagg gggaggccag ggggccctga ggcagcttgg    360

catcggcctg caggcacctc tcaacacaaa cagcctggat gccatggaca gcatgttgat    420

ggcagggggg aagacaggtt cctgggtgga aagggccagg tccccagtaa aacctcacat    480

tga                                                                  483


<210>  4458
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  4458

Met Gly Ser Leu Pro Pro Thr Glu Leu Ala Gly Trp Gly Ser His Ala 
1               5                   10                  15      


Pro Arg His Thr Cys Ser Cys Leu Ala Val Ala Leu Asp Pro Gly Ile 
            20                  25                  30          


Pro Glu Leu Ser Gly Ala Gln Glu Ala Pro Ala Leu Ile Ala Pro Asp 
        35                  40                  45              


Val Pro Ala Pro Thr Pro Trp Thr Leu Pro Ala Pro Ser Ala Cys Ser 
    50                  55                  60                  


Asp Phe Arg Ala Lys Leu Trp Pro Ile Leu Gly Ala Val Val Thr Gln 
65                  70                  75                  80  


Pro Gly Val His Val Leu Gly Ala Val Leu Thr His Gln Pro Pro Ala 
                85                  90                  95      


Val Leu Ala Ala Ser Gly Phe Cys Val Pro Met Ser Met Arg Gly Arg 
            100                 105                 110         


Pro Gly Gly Pro Glu Ala Ala Trp His Arg Pro Ala Gly Thr Ser Gln 
        115                 120                 125             


His Lys Gln Pro Gly Cys His Gly Gln His Val Asp Gly Arg Gly Glu 
    130                 135                 140                 


Asp Arg Phe Leu Gly Gly Lys Gly Gln Val Pro Ser Lys Thr Ser His 
145                 150                 155                 160 


<210>  4459
<211>  795
<212>  DNA
<213>  Homosapiens

<400>  4459
atgaccacac tgcctccttc tcagagtcct gtgactgcca cagccagatt caaggacctc     60

agcctgtact ccgtgatggt gggagtccac cagcgcccag aaaatagcac tcagctcccg    120

ctcactcgca tggtgattca taaggatttc agcaatctca tgtctcagga cattgccctc    180

ctaaagctca gggactccat ctcgtggtcc cccttcgtcc agcctgtctg cctccctaac    240

atcaaattca agccatccat tggaagcatg tgctgggtaa tcggctgggg aactacaggg    300

aaaaaagggg atagggatga gcaggctggg ggtgcccgtt ccacactgca agtctactgg    360

gagtggtacc cgcaggatca ctcagaaagc ctgatgcgta cccctcaaga catggataac    420

actgggctta agaaaggtct gggcccgggg aacaaatggt accacgtggc acagtccaca    480

cagcacaatg cacacaacct ttttactttt tcctccaggg acgctgggct ccactttaag    540

gttgactctg gaagctccct tgtctgccaa atggacaaga cctggattca gataggagtg    600

gtaagctgga gctttagttg tggccagcgc cacttcccag gtatctacac cagcactgcc    660

cacttcaacc agtggatcag gactgaggtt gctaacataa ggttcatcag tagggctggc    720

cctgccttcc tgagcccagt tttcctcact ggctacattc tactgggctc cttgagctcc    780

ctgtggctcc tgtga                                                     795


<210>  4460
<211>  264
<212>  PRT
<213>  Homosapiens

<400>  4460

Met Thr Thr Leu Pro Pro Ser Gln Ser Pro Val Thr Ala Thr Ala Arg 
1               5                   10                  15      


Phe Lys Asp Leu Ser Leu Tyr Ser Val Met Val Gly Val His Gln Arg 
            20                  25                  30          


Pro Glu Asn Ser Thr Gln Leu Pro Leu Thr Arg Met Val Ile His Lys 
        35                  40                  45              


Asp Phe Ser Asn Leu Met Ser Gln Asp Ile Ala Leu Leu Lys Leu Arg 
    50                  55                  60                  


Asp Ser Ile Ser Trp Ser Pro Phe Val Gln Pro Val Cys Leu Pro Asn 
65                  70                  75                  80  


Ile Lys Phe Lys Pro Ser Ile Gly Ser Met Cys Trp Val Ile Gly Trp 
                85                  90                  95      


Gly Thr Thr Gly Lys Lys Gly Asp Arg Asp Glu Gln Ala Gly Gly Ala 
            100                 105                 110         


Arg Ser Thr Leu Gln Val Tyr Trp Glu Trp Tyr Pro Gln Asp His Ser 
        115                 120                 125             


Glu Ser Leu Met Arg Thr Pro Gln Asp Met Asp Asn Thr Gly Leu Lys 
    130                 135                 140                 


Lys Gly Leu Gly Pro Gly Asn Lys Trp Tyr His Val Ala Gln Ser Thr 
145                 150                 155                 160 


Gln His Asn Ala His Asn Leu Phe Thr Phe Ser Ser Arg Asp Ala Gly 
                165                 170                 175     


Leu His Phe Lys Val Asp Ser Gly Ser Ser Leu Val Cys Gln Met Asp 
            180                 185                 190         


Lys Thr Trp Ile Gln Ile Gly Val Val Ser Trp Ser Phe Ser Cys Gly 
        195                 200                 205             


Gln Arg His Phe Pro Gly Ile Tyr Thr Ser Thr Ala His Phe Asn Gln 
    210                 215                 220                 


Trp Ile Arg Thr Glu Val Ala Asn Ile Arg Phe Ile Ser Arg Ala Gly 
225                 230                 235                 240 


Pro Ala Phe Leu Ser Pro Val Phe Leu Thr Gly Tyr Ile Leu Leu Gly 
                245                 250                 255     


Ser Leu Ser Ser Leu Trp Leu Leu 
            260                 


<210>  4461
<211>  207
<212>  DNA
<213>  Homosapiens

<400>  4461
atgacatgct ggatactgat gtgggatttc atccctaaag gcactgttgg ggcatttcaa     60

tacagccaca actggtatta caagtatgtc aaagtgaaga aagggagcac tctcagggtt    120

tctatgctgt tggcagctta catgtttttc aactactgcc tttcttacaa ggagctcaaa    180

cttgaaaggt tatacaagta ctactga                                        207


<210>  4462
<211>  68
<212>  PRT
<213>  Homosapiens

<400>  4462

Met Thr Cys Trp Ile Leu Met Trp Asp Phe Ile Pro Lys Gly Thr Val 
1               5                   10                  15      


Gly Ala Phe Gln Tyr Ser His Asn Trp Tyr Tyr Lys Tyr Val Lys Val 
            20                  25                  30          


Lys Lys Gly Ser Thr Leu Arg Val Ser Met Leu Leu Ala Ala Tyr Met 
        35                  40                  45              


Phe Phe Asn Tyr Cys Leu Ser Tyr Lys Glu Leu Lys Leu Glu Arg Leu 
    50                  55                  60                  


Tyr Lys Tyr Tyr 
65              


<210>  4463
<211>  935
<212>  DNA
<213>  Homosapiens

<400>  4463
atggcgtccc agagcggcag ctccctgggg ctcctggcct ggttcttgct tcttcagcca     60

tggctcgaag aggcccgggc aggcagggtg ggtgcgcagg gaggcgtagc actgctcttc    120

ccctccgcgc tcccctcagg gccaggcggc caggaccccg gagcgagcgg atgggagccg    180

ccacctgtag gggctccagg atccccagcg gccccccagt ccagggggaa cgcagtgcgc    240

cccgcttcgg tgttacttcc ctcagcctgt ggccagcgga cttcaaggat aactggagga    300

ttgccggctc cagacaggaa gtggccctgg caggtgagcc tgcagaccag caacagacac    360

atctgcggag gctcccttat cgccagacac tgggtactca ctgccgctca ctgcatctct    420

gggtgagggt ttggggctca gagcttgggc cctgatcagg ctgtgggacc tggagccagt    480

ctgtccccct ccctgaactt cctcttcctc atctgtaaaa gggggtgaca gccccatagt    540

ttttatccag tctgggtgag acctgaggat ttgcatttct aacaagtttc tgggtgttgc    600

ctccgccgct gatctgggga ctactggcta aagtggtcag gggtcctgga gggatgtggc    660

ttggagagag ggaggtagct gctggctggc ataggaagat ggtaccaggc gggaagcacc    720

tcgaaggtgt ggaagcagag tgtagaccct ggaggatctt cctgcagcca tctggaatac    780

acagtgaagc tgggagacac aaatgtgcat catcgctcca aaacagcact tgtggtccca    840

gttcgtgacg tcgttatcca ccgatatttt acgtctcctg gaataattga aaatgacatt    900

gcccttgccc tgcttgactt ccctgtgaat tactc                               935


<210>  4464
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  4464

Met Ala Ser Gln Ser Gly Ser Ser Leu Gly Leu Leu Ala Trp Phe Leu 
1               5                   10                  15      


Leu Leu Gln Pro Trp Leu Glu Glu Ala Arg Ala Gly Arg Val Gly Ala 
            20                  25                  30          


Gln Gly Gly Val Ala Leu Leu Phe Pro Ser Ala Leu Pro Ser Gly Pro 
        35                  40                  45              


Gly Gly Gln Asp Pro Gly Ala Ser Gly Trp Glu Pro Pro Pro Val Gly 
    50                  55                  60                  


Ala Pro Gly Ser Pro Ala Ala Pro Gln Ser Arg Gly Asn Ala Val Arg 
65                  70                  75                  80  


Pro Ala Ser Val Leu Leu Pro Ser Ala Cys Gly Gln Arg Thr Ser Arg 
                85                  90                  95      


Ile Thr Gly Gly Leu Pro Ala Pro Asp Arg Lys Trp Pro Trp Gln Val 
            100                 105                 110         


Ser Leu Gln Thr Ser Asn Arg His Ile Cys Gly Gly Ser Leu Ile Ala 
        115                 120                 125             


Arg His Trp Val Leu Thr Ala Ala His Cys Ile Ser Gly 
    130                 135                 140     


<210>  4465
<211>  1095
<212>  DNA
<213>  Homosapiens

<400>  4465
tccccgctct gctctgtccg gtcacaggac tttttgccct ctgttcccgg gtccctcagg     60

cggccaccca gtgggcacac tcccaggcgg cgctccggcc ccgcgctccc tccctctgcc    120

tttcattccc agctgtcaac atcctggaag ctttgaagct caggaaagaa gagaaatcca    180

ctgagaacag tctgtaaagg tccgtagtgc tatctacatc cagacggtgg aagggagaga    240

aagagaaaga aggtatccta ggaatacctg cctgcttaga ccctctataa aagctctgtg    300

catcctgcca ctgaggactc cgaagaggta gcagtcttct gaaagacttc aactgtgagg    360

acatgtcgtt cagatttggc caacatctca tcaagccctc tgtagtgttt ctcaaaacag    420

aactgtcctt cgctcttgtg aataggaaac ctgtggtacc aggacatgtc cttgtgtgcc    480

cgctgcggcc agtggagcgc ttccatgacc tgcgtcctga tgaagtggcc gatttgtttc    540

agacgaccca gagagtcggg acagtggtgg aaaaacattt ccatgggacc tctctcacct    600

tttccatgca ggatggcccc gaagccggac agactgtgaa gcacgttcac gtccatgttc    660

ttcccaggaa ggctggagac tttcacagga atgacagcat ctatgaggag ctccagaaac    720

atgacaagga ggactttcct gcctcttgga gatcagagga ggaaatggca gcagaagccg    780

cagctctgcg ggtctacttt cagtgacaca gatgtttttc agatcctgaa ttccagcaaa    840

agagctattg ccaaccagtt tgaagaccgc ccccccgcct ctccccaaga ggaactgaat    900

cagcatgaaa atgcagtttc ttcatctcac catcctgtat tcttcaacca gtgatccccc    960

acctcggtca ctccaactcc cttaaaatac ctagacctaa acggctcaga caggcagatt   1020

tgaggtttcc ccctgtctcc ttattcggca gccttatgat taaacttcct tctctgctgc   1080

aaaaaaaaaa aaaaa                                                    1095


<210>  4466
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  4466

Met Ser Phe Arg Phe Gly Gln His Leu Ile Lys Pro Ser Val Val Phe 
1               5                   10                  15      


Leu Lys Thr Glu Leu Ser Phe Ala Leu Val Asn Arg Lys Pro Val Val 
            20                  25                  30          


Pro Gly His Val Leu Val Cys Pro Leu Arg Pro Val Glu Arg Phe His 
        35                  40                  45              


Asp Leu Arg Pro Asp Glu Val Ala Asp Leu Phe Gln Thr Thr Gln Arg 
    50                  55                  60                  


Val Gly Thr Val Val Glu Lys His Phe His Gly Thr Ser Leu Thr Phe 
65                  70                  75                  80  


Ser Met Gln Asp Gly Pro Glu Ala Gly Gln Thr Val Lys His Val His 
                85                  90                  95      


Val His Val Leu Pro Arg Lys Ala Gly Asp Phe His Arg Asn Asp Ser 
            100                 105                 110         


Ile Tyr Glu Glu Leu Gln Lys His Asp Lys Glu Asp Phe Pro Ala Ser 
        115                 120                 125             


Trp Arg Ser Glu Glu Glu Met Ala Ala Glu Ala Ala Ala Leu Arg Val 
    130                 135                 140                 


Tyr Phe Gln 
145         


<210>  4467
<211>  432
<212>  DNA
<213>  Homosapiens

<400>  4467
atggcagccc gcgcggggaa gcccgagccg caccccagga cctccagctg cccacccttc     60

ggccgcttgc atccccgggc ccggcccggc tgccccgctc cttccttccg tccgcgcgtc    120

cgtccgagcg gcggcacccg gccggctccc ttaagcggag acgcctcccg ccgcctcctc    180

ccacttgccg gtccctccct ctcagctcgc tccggcgaag tttgcacgtc aagcccccgg    240

actggagcca gggcgaagtc ggaaatgcag ccacctatgg aggagccggc cggccggccc    300

cagggcagcg cgggagaggc tggtgcaggg ggcactttgc cctcggcttg cgggcggccg    360

cagagttgtc aaaagcatga atgggaagcc gccgcagagc ggactccggg cgtgcaggga    420

accttgggct ag                                                        432


<210>  4468
<211>  143
<212>  PRT
<213>  Homosapiens

<400>  4468

Met Ala Ala Arg Ala Gly Lys Pro Glu Pro His Pro Arg Thr Ser Ser 
1               5                   10                  15      


Cys Pro Pro Phe Gly Arg Leu His Pro Arg Ala Arg Pro Gly Cys Pro 
            20                  25                  30          


Ala Pro Ser Phe Arg Pro Arg Val Arg Pro Ser Gly Gly Thr Arg Pro 
        35                  40                  45              


Ala Pro Leu Ser Gly Asp Ala Ser Arg Arg Leu Leu Pro Leu Ala Gly 
    50                  55                  60                  


Pro Ser Leu Ser Ala Arg Ser Gly Glu Val Cys Thr Ser Ser Pro Arg 
65                  70                  75                  80  


Thr Gly Ala Arg Ala Lys Ser Glu Met Gln Pro Pro Met Glu Glu Pro 
                85                  90                  95      


Ala Gly Arg Pro Gln Gly Ser Ala Gly Glu Ala Gly Ala Gly Gly Thr 
            100                 105                 110         


Leu Pro Ser Ala Cys Gly Arg Pro Gln Ser Cys Gln Lys His Glu Trp 
        115                 120                 125             


Glu Ala Ala Ala Glu Arg Thr Pro Gly Val Gln Gly Thr Leu Gly 
    130                 135                 140             


<210>  4469
<211>  432
<212>  DNA
<213>  Homosapiens

<400>  4469
atggcagccc gcgcggggaa gcccgagccg caccccagga cctccagctg cccacccttc     60

ggccgcttgc atccccgggc ccggcccggc tgccccgctc cttccttccg tccgcgcgtc    120

cgtccgagcg gcggcacccg gccggctccc ttaagcggag acgcctcccg ccgcctcctc    180

ccacttgccg gtccctccct ctcagctcgc tccggcgaag tttgcacgtc aagcccccgg    240

actggagcca gggcgaagtc ggaaatgcag ccacctatgg aggagccggc cggccggccc    300

cagggcagcg cgggagaggc tggtgcaggg ggcactttgc cctcggcttg cgggcggccg    360

cagagttgtc aaaagcatga atgggaagcc gccgcagagc ggactccggg cgtgcaggga    420

accttgggct ag                                                        432


<210>  4470
<211>  143
<212>  PRT
<213>  Homosapiens

<400>  4470

Met Ala Ala Arg Ala Gly Lys Pro Glu Pro His Pro Arg Thr Ser Ser 
1               5                   10                  15      


Cys Pro Pro Phe Gly Arg Leu His Pro Arg Ala Arg Pro Gly Cys Pro 
            20                  25                  30          


Ala Pro Ser Phe Arg Pro Arg Val Arg Pro Ser Gly Gly Thr Arg Pro 
        35                  40                  45              


Ala Pro Leu Ser Gly Asp Ala Ser Arg Arg Leu Leu Pro Leu Ala Gly 
    50                  55                  60                  


Pro Ser Leu Ser Ala Arg Ser Gly Glu Val Cys Thr Ser Ser Pro Arg 
65                  70                  75                  80  


Thr Gly Ala Arg Ala Lys Ser Glu Met Gln Pro Pro Met Glu Glu Pro 
                85                  90                  95      


Ala Gly Arg Pro Gln Gly Ser Ala Gly Glu Ala Gly Ala Gly Gly Thr 
            100                 105                 110         


Leu Pro Ser Ala Cys Gly Arg Pro Gln Ser Cys Gln Lys His Glu Trp 
        115                 120                 125             


Glu Ala Ala Ala Glu Arg Thr Pro Gly Val Gln Gly Thr Leu Gly 
    130                 135                 140             


<210>  4471
<211>  3067
<212>  DNA
<213>  Homosapiens

<400>  4471
actgggggga gcaaagagtg gggaactggg caggcagaca cccccacaga gcactcatgg     60

cccccacaga aatacaccca cactcatcac agcaaaccaa aacaatcaca cgccggtaca    120

caaacacaca cacccccgca ccaatccagg cagacacaaa gctcacggcg acaggcagat    180

ctgattcaca cagacacagg cacaggtgct tcctgatgcc accctctctt ggtcacgtgc    240

cagcacttgg agggaggaaa gtgcctcacc aggctgagat gcccaaggga ccccccaggg    300

agggaaagca ggacacactg ggacagttgc ttccagccct gtccacaccc ttgtgcccat    360

caggtatgcc gctcaccccc accccacctg gaccttggtg tcacctagga ttgcagaggc    420

cgccttcagc ccagagcctg gggccttgcc cactgcctca cctcccagga tagggcatgc    480

tgttcctttc tccttccctt tctttgctct tgtgtgcctg cctttagcaa acgcccactg    540

ggtgtgtggg tacactgcgg cctttaaaga gaagagaaac acatgaggct tacagcagga    600

ggccctgcct aggttccaag ggacatggag cagggtggct gtgtagagct ggggagcatc    660

ccaagcctgt gccaaggttc caaggacaaa aagggcaagg aggcccagtg cggggtggtg    720

ggggagcagc tagccagggc caacagtgag cctcgcgcct gggcaggtgt agcctttaaa    780

cgcggtgggg gaaccatgga cagcatctaa gcagggacgt gccgtgagtc ctgggggtgc    840

aggggtgtct agaggggaag ctgggaagca ggggtcacag ctttccgact ggtggctgag    900

tgtggggaag acaggagggg caggtgtgag atgtacagca gacacagctg tgtgctgggg    960

catggtgggc tgtggtgaga gagaggagca ggtcttctcc ccgcgtgttc agagcagatc   1020

caaactcttc tcccattcct tcctccaccg tgcatcctca gcacccctca gcactggcct   1080

gtgtgggcag cgtgagcaca gagagcagga gcttgccctc agaggcttca gggggtcgct   1140

tgtacccagt ggtatggtca gcatcatgtt tgaccaaagg gaggaaggtg gctgtgacca   1200

gagcgagggg gggtcctgat gcagctgggg agtcaggctc gagtgcatgc tgtgcatgtt   1260

ctctgcctct cttcctgggg ggcaggcgag tctccagagc ctggaggaca agttagcctt   1320

gcgaaggata gcagaggacc cagcccaggg gtccccaaaa tggagcacca accctccatg   1380

caggccaagc cactggtgaa tatgctgcaa aaaatatgct ggaacttcta tgaataccac   1440

agggtgtgag aagaaaacat tagaacttct attttgtacc tgtgttactc cacaacaaga   1500

aagcaatcag cttgatcaat gcctactgta aagacggcac cgccctccgg aggtcctttc   1560

tcagccctgg tgttcggaca gccacatccc ctcgcagcag ggggaggcct gaagcataga   1620

ggggcccatg caggtctatt ctgtttcagc gaattgcctg ggaaataatc caggatccat   1680

ttcgtgtggt catcttgtct ccctggtccc ctccagcctt tcctcatctt ttgtgacctg   1740

gtcactctgg aagggcgctg gccagttagt ccacaggatg ggcctcccct ggggcttttc   1800

tgatgcttcc ttatgatggc actggcatcc tgagggggag gaccacagag aggaggtgct   1860

cctcatcaca ccacatgggg gtccatgcac cagtgccact gctttccagg gctcttcacc   1920

ttcatcactg gtggaggtgg cgtctgccaa gaagcagaaa gttgaggctt agaaggtgca   1980

cggccctacc tcttccgagg tgcccctgcg ggctgtctac agaccaggca gcacatgcct   2040

gatagcagct gcataaggaa aagcaggagc cagctcgtgc acagtggcct caagtgtgca   2100

ctgggcatgt tctctgcctc accatccctg tgtgacagat gaagcatgac agccctcaac   2160

agaagccaag gccaagtcct cgaacttcct agtctgcaca atgacacttc tgatgaaact   2220

gaaaatgcca ccagggagaa gcagctgaac ttcaaggacc acagagggcc aagtgcagga   2280

gtaagaggct ggcgtgctga cagtggccaa gggcattgga gggaaggacc tgtcatcact   2340

gggccaagga aggaactcca gactgcctac ttccagaggg cctgctgagg aattttagct   2400

tgaacttgcc tgccttgact agggctttct gagcagcaga tgattctgca atggtgttag   2460

tccaggcctg gttctgcatg acattgacca tactgtgcac cctggggtca ttatgtcttg   2520

ggcttcaagg ggctccatgg gctccagggg gctccatgtg acactgcaca gagctctctc   2580

taggtcacct ggatgtgtct cttcctagga accccaaaga gctctctcaa caaacacacc   2640

cacgagttcc aggagtgagg ctgcagggaa cagcctcact ctcagagggg atacagaatt   2700

gttccactgg acaagggctg ggatcgtcat aggatgccgt tggcctgtgg tttccaacag   2760

aggtgcagtt cattgaactg tggtctacag tccattctct aacttgggga cccttgaaga   2820

agtgtggaat catgacaaca accctgttgg gagacactat tattcccatc acatggatga   2880

gcacacggag gcaaaaggaa gttatatgat tgtctgagat cacccagtga agactgtgtg   2940

gctgggagtt gtccccagtg ttatctgcac gctgcttcct tttgatgcct ggcccttctt   3000

tatcaaaaga agcattggca gaatctgggt gtttatgggt cagctcaaaa taaattactt   3060

tatatgt                                                             3067


<210>  4472
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  4472

Met Thr Ala Leu Asn Arg Ser Gln Gly Gln Val Leu Glu Leu Pro Ser 
1               5                   10                  15      


Leu His Asn Asp Thr Ser Asp Glu Thr Glu Asn Ala Thr Arg Glu Lys 
            20                  25                  30          


Gln Leu Asn Phe Lys Asp His Arg Gly Pro Ser Ala Gly Val Arg Gly 
        35                  40                  45              


Trp Arg Ala Asp Ser Gly Gln Gly His Trp Arg Glu Gly Pro Val Ile 
    50                  55                  60                  


Thr Gly Pro Arg Lys Glu Leu Gln Thr Ala Tyr Phe Gln Arg Ala Cys 
65                  70                  75                  80  


<210>  4473
<211>  3067
<212>  DNA
<213>  Homosapiens

<400>  4473
actgggggga gcaaagagtg gggaactggg caggcagaca cccccacaga gcactcatgg     60

cccccacaga aatacaccca cactcatcac agcaaaccaa aacaatcaca cgccggtaca    120

caaacacaca cacccccgca ccaatccagg cagacacaaa gctcacggcg acaggcagat    180

ctgattcaca cagacacagg cacaggtgct tcctgatgcc accctctctt ggtcacgtgc    240

cagcacttgg agggaggaaa gtgcctcacc aggctgagat gcccaaggga ccccccaggg    300

agggaaagca ggacacactg ggacagttgc ttccagccct gtccacaccc ttgtgcccat    360

caggtatgcc gctcaccccc accccacctg gaccttggtg tcacctagga ttgcagaggc    420

cgccttcagc ccagagcctg gggccttgcc cactgcctca cctcccagga tagggcatgc    480

tgttcctttc tccttccctt tctttgctct tgtgtgcctg cctttagcaa acgcccactg    540

ggtgtgtggg tacactgcgg cctttaaaga gaagagaaac acatgaggct tacagcagga    600

ggccctgcct aggttccaag ggacatggag cagggtggct gtgtagagct ggggagcatc    660

ccaagcctgt gccaaggttc caaggacaaa aagggcaagg aggcccagtg cggggtggtg    720

ggggagcagc tagccagggc caacagtgag cctcgcgcct gggcaggtgt agcctttaaa    780

cgcggtgggg gaaccatgga cagcatctaa gcagggacgt gccgtgagtc ctgggggtgc    840

aggggtgtct agaggggaag ctgggaagca ggggtcacag ctttccgact ggtggctgag    900

tgtggggaag acaggagggg caggtgtgag atgtacagca gacacagctg tgtgctgggg    960

catggtgggc tgtggtgaga gagaggagca ggtcttctcc ccgcgtgttc agagcagatc   1020

caaactcttc tcccattcct tcctccaccg tgcatcctca gcacccctca gcactggcct   1080

gtgtgggcag cgtgagcaca gagagcagga gcttgccctc agaggcttca gggggtcgct   1140

tgtacccagt ggtatggtca gcatcatgtt tgaccaaagg gaggaaggtg gctgtgacca   1200

gagcgagggg gggtcctgat gcagctgggg agtcaggctc gagtgcatgc tgtgcatgtt   1260

ctctgcctct cttcctgggg ggcaggcgag tctccagagc ctggaggaca agttagcctt   1320

gcgaaggata gcagaggacc cagcccaggg gtccccaaaa tggagcacca accctccatg   1380

caggccaagc cactggtgaa tatgctgcaa aaaatatgct ggaacttcta tgaataccac   1440

agggtgtgag aagaaaacat tagaacttct attttgtacc tgtgttactc cacaacaaga   1500

aagcaatcag cttgatcaat gcctactgta aagacggcac cgccctccgg aggtcctttc   1560

tcagccctgg tgttcggaca gccacatccc ctcgcagcag ggggaggcct gaagcataga   1620

ggggcccacg caggtctatt ctgtttcagc gaattgcctg ggaaataatc caggatccat   1680

ttcgtgtggt catcttgtct ccctggtccc ctccagcctt tcctcatctt ttgtgacctg   1740

gtcactctgg aagggcgctg gccagttagt ccacaggatg ggcctcccct ggggcttttc   1800

tgatgcttcc ttatgatggc actggcatcc tgagggggag gaccacagag aggaggtgct   1860

cctcatcaca ccacatgggg gtccatgcac cagtgccact gctttccagg gctcttcacc   1920

ttcatcactg gtggaggtgg cgtctgccaa gaagcagaaa gttgatgctt agaaggtgca   1980

tggccctacc tcttctaagg tgcccctgcg ggctgtctac agaccaggca gcacatgcct   2040

gatagcagct gcataaggaa aagcaggagc cagctcgtgc acagtggcct caagtgtgcg   2100

ctgggcatgt tatctgcctc accatccctg tgtgacagat gaagcatgac agccctcaac   2160

agaagccaag gccaagtcct cgaacttcct agtctgcaca atgacacttc tgatgaaact   2220

gaaaatgcca ccagggagaa gcagctgaac ttcaaggacc acagagggcc aagtgcagga   2280

gtaagaggct ggcgtgctga cagtggccaa gggcattgga gggaaggacc tgtcatcact   2340

gggccaagga aggaactcca gactgcctac ttccagaggg cctgctgagg aattttagct   2400

tgaacttgcc tgccttgact agggctttct gagcagcaga tgattctgca atggtgttag   2460

tccaggcctg gttctgcatg acattgacca tactgtgcac cctggggtca ttatgtcttg   2520

ggcttcaagg ggctccatgg gctccagggg gctccatgtg acactgcaca gagctctctc   2580

taggtcacct ggatgtgtct cttcctagga accccaaaga gctctctcaa caaacacacc   2640

cacgagttcc aggagtgagg ctgcagggaa cagcctcact ctcagagggg atacagaatt   2700

gttccactgg acaagggctg ggatcgtcat aggatgccgt tggcctgtgg tttccaacag   2760

aggtgcagtt cattgaactg tggtctacag tccattctct aacttgggga cccttgaaga   2820

agtgtggaat catgacaaca accctgttgg gagacactat tattcccatc acatggatga   2880

gcacacggag gcaaaaggaa gttatatgat tgtctgagat cacccagtga agactgtgtg   2940

gctgggagtt gtccccagtg ttatctgcac gctgcttcct tttgatgcct ggcccttctt   3000

tatcaaaaga agcattggca gaatctgggt gtttatgggt cagctcaaaa taaattactt   3060

tatatgt                                                             3067


<210>  4474
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  4474

Met Thr Ala Leu Asn Arg Ser Gln Gly Gln Val Leu Glu Leu Pro Ser 
1               5                   10                  15      


Leu His Asn Asp Thr Ser Asp Glu Thr Glu Asn Ala Thr Arg Glu Lys 
            20                  25                  30          


Gln Leu Asn Phe Lys Asp His Arg Gly Pro Ser Ala Gly Val Arg Gly 
        35                  40                  45              


Trp Arg Ala Asp Ser Gly Gln Gly His Trp Arg Glu Gly Pro Val Ile 
    50                  55                  60                  


Thr Gly Pro Arg Lys Glu Leu Gln Thr Ala Tyr Phe Gln Arg Ala Cys 
65                  70                  75                  80  


<210>  4475
<211>  363
<212>  DNA
<213>  Homosapiens

<400>  4475
atgtccctga gaaggctgtg tgggccccag caggcaggtg ggttgacctg ggagcagcgc     60

ctgcaaggct ggcacttgca caccatcccg ttacacagag ccttcctgcg gttcctgagt    120

gtggtgggga tcctcccgcc acagctggca gccccatgtc tcctctggct gcacacagga    180

tcactaggga actttaaaaa ggcactgatg ccagggctcc acttcggcca atacaatcag    240

tctctcaggg cagcactggg aggaggtgtt tgtggtgttt catggacaca cacactgcca    300

gcatcaggga gtagtgacag ggtactgaga acagcagaat atctagaagt gagttcttca    360

taa                                                                  363


<210>  4476
<211>  120
<212>  PRT
<213>  Homosapiens

<400>  4476

Met Ser Leu Arg Arg Leu Cys Gly Pro Gln Gln Ala Gly Gly Leu Thr 
1               5                   10                  15      


Trp Glu Gln Arg Leu Gln Gly Trp His Leu His Thr Ile Pro Leu His 
            20                  25                  30          


Arg Ala Phe Leu Arg Phe Leu Ser Val Val Gly Ile Leu Pro Pro Gln 
        35                  40                  45              


Leu Ala Ala Pro Cys Leu Leu Trp Leu His Thr Gly Ser Leu Gly Asn 
    50                  55                  60                  


Phe Lys Lys Ala Leu Met Pro Gly Leu His Phe Gly Gln Tyr Asn Gln 
65                  70                  75                  80  


Ser Leu Arg Ala Ala Leu Gly Gly Gly Val Cys Gly Val Ser Trp Thr 
                85                  90                  95      


His Thr Leu Pro Ala Ser Gly Ser Ser Asp Arg Val Leu Arg Thr Ala 
            100                 105                 110         


Glu Tyr Leu Glu Val Ser Ser Ser 
        115                 120 


<210>  4477
<211>  976
<212>  DNA
<213>  Homosapiens

<400>  4477
atgtatacac ctgccacagg ctctaagtgc ctaagaagtg taaaccaatt ccatcttcat     60

gctgacggga cccgagtgaa ttcgggttct tcagcccctc agtgccctcc cggagccctt    120

tacctgaacg ggagcctgag agaacggacg acaggagccg agtggaaagc agtgcccgcg    180

ccggagatca gcgccgaggg cgggagccga cgtctaggga ccacagagcc gcgacgcggc    240

gagccgcgca cgggccattc cgccgccgcg aacgcagaaa gcctcgaccg cgctccgagt    300

ccagccagct cgcctgtcac ctcgatctct gctttaagtg gcttccggtc gcctcctccc    360

gacggcccgt cgcggaggcg gagcctgggc ggccggagtt cggtggggtg gggtgaggag    420

gccgggcgct cagtgggtgt cgggaagaag acccgccccc tgcgcgcgcg tgcgcgttcg    480

ttcgagggga ggcgcgcgag ttctgtgcgg tggacttatg ctcccgcgag ggggcgtgtc    540

ctttctcgcg tccgcagtgt ccctgagggt ccgcgtctac acgcggctgt gaggaaggaa    600

ggcgcgtgcc gcgtgggacg ggctccacct gcctgcggac agatggaggg tcactttgtt    660

ccgagaagac ccagacaccc gagggaggat gtgaaacgga acgacccgtt tcgagtaata    720

acaggatgga gatggagttt catgacaaaa atgaaggtga atatgatgtg gaaaatacaa    780

agatggaagc aacaagctaa ggatgctggg gcagaaagat ggaacctggg ttactcatga    840

catcttgaaa ctgctgcagc catcctagac tggctgcctc tagacttaat atgtttagaa    900

agtaaatccc aattttatta aactgttatc tgttatgtat atatgaacac attcttagct    960

aataaactat catgtc                                                    976


<210>  4478
<211>  279
<212>  PRT
<213>  Homosapiens

<400>  4478

Met Tyr Thr Pro Ala Thr Gly Ser Lys Cys Leu Arg Ser Val Asn Gln 
1               5                   10                  15      


Phe His Leu His Ala Asp Gly Thr Arg Val Asn Ser Gly Ser Ser Ala 
            20                  25                  30          


Pro Gln Cys Pro Pro Gly Ala Leu Tyr Leu Asn Gly Ser Leu Arg Glu 
        35                  40                  45              


Arg Thr Thr Gly Ala Glu Trp Lys Ala Val Pro Ala Pro Glu Ile Ser 
    50                  55                  60                  


Ala Glu Gly Gly Ser Arg Arg Leu Gly Thr Thr Glu Pro Arg Arg Gly 
65                  70                  75                  80  


Glu Pro Arg Thr Gly His Ser Ala Ala Ala Asn Ala Glu Ser Leu Asp 
                85                  90                  95      


Arg Ala Pro Ser Pro Ala Ser Ser Pro Val Thr Ser Ile Ser Ala Leu 
            100                 105                 110         


Ser Gly Phe Arg Ser Pro Pro Pro Asp Gly Pro Ser Arg Arg Arg Ser 
        115                 120                 125             


Leu Gly Gly Arg Ser Ser Val Gly Trp Gly Glu Glu Ala Gly Arg Ser 
    130                 135                 140                 


Val Gly Val Gly Lys Lys Thr Arg Pro Leu Arg Ala Arg Ala Arg Ser 
145                 150                 155                 160 


Phe Glu Gly Arg Arg Ala Ser Ser Val Arg Trp Thr Tyr Ala Pro Ala 
                165                 170                 175     


Arg Gly Arg Val Leu Ser Arg Val Arg Ser Val Pro Glu Gly Pro Arg 
            180                 185                 190         


Leu His Ala Ala Val Arg Lys Glu Gly Ala Cys Arg Val Gly Arg Ala 
        195                 200                 205             


Pro Pro Ala Cys Gly Gln Met Glu Gly His Phe Val Pro Arg Arg Pro 
    210                 215                 220                 


Arg His Pro Arg Glu Asp Val Lys Arg Asn Asp Pro Phe Arg Val Ile 
225                 230                 235                 240 


Thr Gly Trp Arg Trp Ser Phe Met Thr Lys Met Lys Val Asn Met Met 
                245                 250                 255     


Trp Lys Ile Gln Arg Trp Lys Gln Gln Ala Lys Asp Ala Gly Ala Glu 
            260                 265                 270         


Arg Trp Asn Leu Gly Tyr Ser 
        275                 


<210>  4479
<211>  976
<212>  DNA
<213>  Homosapiens

<400>  4479
atgtatacac ctgccacagg ctctaagtgc ctaagaagtg taaaccaatt ccatcttcat     60

gctgacggga cccgagtgaa ttcgggttct tcagcccctc agtgccctcc cggagccctt    120

tacctgaacg ggagcctgag agaacggacg acaggagccg agtggaaagc agtgcccgcg    180

ccggagatca gcgccgaggg cgggagccga cgtctaggga ccacagagcc gcgacgcggc    240

gagccgcgca cgggccattc cgccgccgcg aacgcagaaa gcctcgaccg cgctccgagt    300

ccagccagct cgcctgtcac ctcgatctct gctttaagtg gcttccggtc gcctcctccc    360

gacggcccgt cgcggaggcg gagcctgggc ggccggagtt cggtggggtg gggtgaggag    420

gccgggcgct cagtgggtgt cgggaagaag acccgccccc tgcgcgcgcg tgcgcgttcg    480

ttcgagggga ggcgcgcgag ttctgtgcgg tggacttgtg ctcccgcgag ggggcgtgtc    540

ctttctcgcg tccgcagtgt ccctgagggt ccgcgtctac acgcggctgt gaggaaggaa    600

ggcgcgtgcc gcgtgggacg ggctccacct gcctgcggac agatggaggg tcactttgtt    660

ccgagaagac ccagacaccc gagggaggat gtgaaacgga acgacccgtt tcgagtaata    720

acaggatgga gatggagttt catgacaaaa atgaaggtga atatgatgtg gaaaatacaa    780

agatggaagc aacaagctaa ggatgctggg gcagaaagat ggaacctggg ttactcatga    840

catcttgaaa ctgctgcagc catcctagac tggctgcctc tagacttaat atgtttagaa    900

agtaaatccc aattttatta aactgttatc tgttatgtat atatgaacac attcttagct    960

aataaactat catgtc                                                    976


<210>  4480
<211>  279
<212>  PRT
<213>  Homosapiens

<400>  4480

Met Tyr Thr Pro Ala Thr Gly Ser Lys Cys Leu Arg Ser Val Asn Gln 
1               5                   10                  15      


Phe His Leu His Ala Asp Gly Thr Arg Val Asn Ser Gly Ser Ser Ala 
            20                  25                  30          


Pro Gln Cys Pro Pro Gly Ala Leu Tyr Leu Asn Gly Ser Leu Arg Glu 
        35                  40                  45              


Arg Thr Thr Gly Ala Glu Trp Lys Ala Val Pro Ala Pro Glu Ile Ser 
    50                  55                  60                  


Ala Glu Gly Gly Ser Arg Arg Leu Gly Thr Thr Glu Pro Arg Arg Gly 
65                  70                  75                  80  


Glu Pro Arg Thr Gly His Ser Ala Ala Ala Asn Ala Glu Ser Leu Asp 
                85                  90                  95      


Arg Ala Pro Ser Pro Ala Ser Ser Pro Val Thr Ser Ile Ser Ala Leu 
            100                 105                 110         


Ser Gly Phe Arg Ser Pro Pro Pro Asp Gly Pro Ser Arg Arg Arg Ser 
        115                 120                 125             


Leu Gly Gly Arg Ser Ser Val Gly Trp Gly Glu Glu Ala Gly Arg Ser 
    130                 135                 140                 


Val Gly Val Gly Lys Lys Thr Arg Pro Leu Arg Ala Arg Ala Arg Ser 
145                 150                 155                 160 


Phe Glu Gly Arg Arg Ala Ser Ser Val Arg Trp Thr Cys Ala Pro Ala 
                165                 170                 175     


Arg Gly Arg Val Leu Ser Arg Val Arg Ser Val Pro Glu Gly Pro Arg 
            180                 185                 190         


Leu His Ala Ala Val Arg Lys Glu Gly Ala Cys Arg Val Gly Arg Ala 
        195                 200                 205             


Pro Pro Ala Cys Gly Gln Met Glu Gly His Phe Val Pro Arg Arg Pro 
    210                 215                 220                 


Arg His Pro Arg Glu Asp Val Lys Arg Asn Asp Pro Phe Arg Val Ile 
225                 230                 235                 240 


Thr Gly Trp Arg Trp Ser Phe Met Thr Lys Met Lys Val Asn Met Met 
                245                 250                 255     


Trp Lys Ile Gln Arg Trp Lys Gln Gln Ala Lys Asp Ala Gly Ala Glu 
            260                 265                 270         


Arg Trp Asn Leu Gly Tyr Ser 
        275                 


<210>  4481
<211>  857
<212>  DNA
<213>  Homosapiens

<400>  4481
cgcggtcgcc cgggagaccg ggaaagccgt ttcacacccg tcctagtcga agtcgagatt     60

tcctttggct tcaaagctct ctcaccatat tttgggaagt tatggatcat cacattccca    120

tgcatgcgtt gcctgaagaa atccaaaaga tgttgcctga agaaaaagtt tgtaagtact    180

gtggagtcag ctatctaatt cttcatgaat ttaaggctat ggaagaaaaa gtgaaagcaa    240

tggaaaaaga gatgaaattt tatcaaggaa gtgtagatcg tgaaaagaga cttcaagaaa    300

agctgcattc tcttagccaa gaacttgaac agtacaaaat tgacaacaaa tccaaaacag    360

aaagaattta cgatgtaggc atgcagttaa aaagtcaaca aaatgaattt cagaaagtaa    420

agaaacaact gagtcatttg caagatgagc taaaaattaa atatagacaa tcatacatct    480

tcagattgtg cttttgctga tgtctgtaag aactctgtct aagccggtca gaaggatttt    540

ctcctgtatt ttcttctaag tgttttatag ttttagctct tctttagatc tatgatctat    600

ttcagctaac ttctgtgtat gatatgaggt aagaatctaa attcatcctg tttcacgtgg    660

atattcaatt gttccagtgc tgtttgttag aggccaattt ttccttattg aattgcctca    720

gcatctttgc ctaaaataaa ttcaccataa atgtaaagga ttatttttgg attttctatt    780

ctattccatt aatctatatg tcttatgtca gtgccacact ctcttaagta ctacagtttt    840

taataaattt taaaatc                                                   857


<210>  4482
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  4482

Met Asp His His Ile Pro Met His Ala Leu Pro Glu Glu Ile Gln Lys 
1               5                   10                  15      


Met Leu Pro Glu Glu Lys Val Cys Lys Tyr Cys Gly Val Ser Tyr Leu 
            20                  25                  30          


Ile Leu His Glu Phe Lys Ala Met Glu Glu Lys Val Lys Ala Met Glu 
        35                  40                  45              


Lys Glu Met Lys Phe Tyr Gln Gly Ser Val Asp Arg Glu Lys Arg Leu 
    50                  55                  60                  


Gln Glu Lys Leu His Ser Leu Ser Gln Glu Leu Glu Gln Tyr Lys Ile 
65                  70                  75                  80  


Asp Asn Lys Ser Lys Thr Glu Arg Ile Tyr Asp Val Gly Met Gln Leu 
                85                  90                  95      


Lys Ser Gln Gln Asn Glu Phe Gln Lys Val Lys Lys Gln Leu Ser His 
            100                 105                 110         


Leu Gln Asp Glu Leu Lys Ile Lys Tyr Arg Gln Ser Tyr Ile Phe Arg 
        115                 120                 125             


Leu Cys Phe Cys 
    130         


<210>  4483
<211>  1060
<212>  DNA
<213>  Homosapiens

<400>  4483
atggagtggt actggtctgt ggcctgttgg gcagtgggcc ccacagcagt aggtgagtgg     60

caggttgcag atgtcttaga aacacattcc tgcaccacag cttcaagaaa tccaaataat    120

gacctgatct gctggtttcc aagctaccct accaggagca agtcagaggc cctgcagggc    180

tcctcggtaa gccctcgaaa tccctctccc ctcaatgacc ccaccacagc agctccactt    240

ttgaatattt taccagtgcg tgttccagag ttgccttgga atcctgccta ctgcagatta    300

cagtgctgca ggtctggagt ggggctgaga cttcgcgtct taacaagctg ctctcagttg    360

atgctgatcc tcatggtcca atgtatgaca atgctgttga atgtgcctct tcatttcagc    420

acactgcctt caggcaggga atgggccact cctggcaccc tgcacatttt agcatttgtt    480

tcctgtctct ccccactaga atgcaagctg cagaggaatt gtatccgtag cacctggctt    540

cgcagaccaa gagcaagtcg gcacaccagg acaggcactc gcatgggtgc ccagaagttt    600

caagatctga ccttggagag accaggtccg ggaggctgcc gggaagtctc catcacaccg    660

gcctcagccg agtcacagga acgcaggctc tgccatgccc agaagcctga gatgcaactt    720

caaggacaac gggagccaga acgcttgacc tcacacggaa ggtgactcct aaccaccacc    780

acacttgacg tagcaccagc acacggagat taggcctaca ccaatggcta attgagacca    840

tgcatcacta ttaaggcatc ttcagcaaaa ggaactatgg aagttctgca tgaaacatag    900

acacctgtta gaaaaggaac taaatttcaa accgggaatg tggtgttgaa tcacagcaaa    960

gtgtccagaa ggaactccca aagtactgtt ttccaaaata tagaatgata tagaagattg   1020

ttttaggtgg aattcctgga aataaatttt taaatgtttc                         1060


<210>  4484
<211>  254
<212>  PRT
<213>  Homosapiens

<400>  4484

Met Glu Trp Tyr Trp Ser Val Ala Cys Trp Ala Val Gly Pro Thr Ala 
1               5                   10                  15      


Val Gly Glu Trp Gln Val Ala Asp Val Leu Glu Thr His Ser Cys Thr 
            20                  25                  30          


Thr Ala Ser Arg Asn Pro Asn Asn Asp Leu Ile Cys Trp Phe Pro Ser 
        35                  40                  45              


Tyr Pro Thr Arg Ser Lys Ser Glu Ala Leu Gln Gly Ser Ser Val Ser 
    50                  55                  60                  


Pro Arg Asn Pro Ser Pro Leu Asn Asp Pro Thr Thr Ala Ala Pro Leu 
65                  70                  75                  80  


Leu Asn Ile Leu Pro Val Arg Val Pro Glu Leu Pro Trp Asn Pro Ala 
                85                  90                  95      


Tyr Cys Arg Leu Gln Cys Cys Arg Ser Gly Val Gly Leu Arg Leu Arg 
            100                 105                 110         


Val Leu Thr Ser Cys Ser Gln Leu Met Leu Ile Leu Met Val Gln Cys 
        115                 120                 125             


Met Thr Met Leu Leu Asn Val Pro Leu His Phe Ser Thr Leu Pro Ser 
    130                 135                 140                 


Gly Arg Glu Trp Ala Thr Pro Gly Thr Leu His Ile Leu Ala Phe Val 
145                 150                 155                 160 


Ser Cys Leu Ser Pro Leu Glu Cys Lys Leu Gln Arg Asn Cys Ile Arg 
                165                 170                 175     


Ser Thr Trp Leu Arg Arg Pro Arg Ala Ser Arg His Thr Arg Thr Gly 
            180                 185                 190         


Thr Arg Met Gly Ala Gln Lys Phe Gln Asp Leu Thr Leu Glu Arg Pro 
        195                 200                 205             


Gly Pro Gly Gly Cys Arg Glu Val Ser Ile Thr Pro Ala Ser Ala Glu 
    210                 215                 220                 


Ser Gln Glu Arg Arg Leu Cys His Ala Gln Lys Pro Glu Met Gln Leu 
225                 230                 235                 240 


Gln Gly Gln Arg Glu Pro Glu Arg Leu Thr Ser His Gly Arg 
                245                 250                 


<210>  4485
<211>  631
<212>  DNA
<213>  Homosapiens

<400>  4485
atccatgtaa gatgtgactt gctcctcctt gccttctgcc atgattgtga ggcctcccca     60

gccacttgga actgaagcaa acactgctat tgccaccttt ttgcagagga aggtactgag    120

gtgaagcgac ttgcccaaac cctacaaaaa gcactgtgcc aggtgctgga tttataacca    180

caaaaacaga ggggcagaat gtctgcattt ccagtgggca agacagacaa tgtgcctatc    240

tgtgcatttc cttgtaaaat ccagctttcg caagagcatg aacaaatcag tttggcaaga    300

cctccccacc ctcaacatct gatcacgtgt ctcatcctcc atgatgccac aggtggtctt    360

cagggctgtc tccatgaagt catcaccagc cttcccaggc caggactctc catgccatcc    420

ttagcaagga gaagaaaaca aatacccggc atccatttcc aggtcctgca tgatgtgatg    480

tcagaagaga agacaggaat atatgaaaca ggagcaatca caagaacgta acagaggaca    540

caggtgtcat gttcatggca cagaacagaa gccccataga gttcaaaaga cgggatgact    600

ggagatatcc ttgacacatt gagctaaaaa a                                   631


<210>  4486
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  4486

Met Ser Ala Phe Pro Val Gly Lys Thr Asp Asn Val Pro Ile Cys Ala 
1               5                   10                  15      


Phe Pro Cys Lys Ile Gln Leu Ser Gln Glu His Glu Gln Ile Ser Leu 
            20                  25                  30          


Ala Arg Pro Pro His Pro Gln His Leu Ile Thr Cys Leu Ile Leu His 
        35                  40                  45              


Asp Ala Thr Gly Gly Leu Gln Gly Cys Leu His Glu Val Ile Thr Ser 
    50                  55                  60                  


Leu Pro Arg Pro Gly Leu Ser Met Pro Ser Leu Ala Arg Arg Arg Lys 
65                  70                  75                  80  


Gln Ile Pro Gly Ile His Phe Gln Val Leu His Asp Val Met Ser Glu 
                85                  90                  95      


Glu Lys Thr Gly Ile Tyr Glu Thr Gly Ala Ile Thr Arg Thr 
            100                 105                 110 


<210>  4487
<211>  2865
<212>  DNA
<213>  Homosapiens

<400>  4487
tgccgccagg agtggcagga ggcgagctga gtgaaatgag ctgctccagt tcccgcccac     60

gaagggggtt aagatgaagg gaacaatcct gtctcatctg ggggcctgtc caggatatga    120

aaaacaagta tcactccatc acccaggctg gagcacagtg gtgcaacctc agctcactgc    180

aagctctgcc tcctgggttc gagtgattca tgtgcctcag cctcccaaga agctggaatt    240

acagactcta cccaacaaca gcagaataca cattttcttc aggttgacca agagcattaa    300

ccaagagtaa tcaaaaagag gagccgacta gacacagcca ggaagagctt ctcccaccgg    360

aagaccagac cagcaagaaa gttggcaccc tccaagcagg ttgttgaaag gaaggccttg    420

aatgtggaca gaggacgatg cagatgagga aagactagaa ggttctgtac ctgttaacag    480

tggctgatcc tagaagagtg aaatttaggc aggtagttgg aaagaacaca gcacagaaaa    540

ctttaggatg aattttccta gcagccattc tgtatcgtca aagccttcaa tccctgagga    600

gagagttaat ggcacacagg agtggggtga tttgggcaat gagtgcttct tcctttcaac    660

ctgttgctgc ctaacacaag gacaattggt cttccaccct cttcacagtt cattcagtca    720

ttgtccctgt ctcccaggtg agttgagtga aaataatggt gacaagaagc ccactgcctg    780

attcacataa gcaaggcatg ctgcagggaa gacagggttc ttattaatat ttcctttcat    840

gtgcttacat atgagttaca gttgctaatc ctttcccaca gtttagcacc tagttaaaag    900

aaagggcttc ggaatcaggt aagtgtagat taaagttata acggcaaatt gctgaacctt    960

tggaagcctc ggtttttcca cctggaaaat ggatttttat cttacaggac tgtcgtgagg   1020

attgatgagc taacattcct aaatcaggga gtttgaagtc tggcccagga tcgtctagat   1080

tttgacgttc tccttgtctt tgctgtgtac ccctgggaga aacaaagggt gagaagaaac   1140

aagggaaagg agaaacattt gtgttttcca acttttcagt gttgatcagc cagcgggaat   1200

aaagagaaga tgtgtaagat ggagggcaaa agagattccc agaagctgct gcagatctct   1260

tccagttgca tttcgaaagc cattacttaa gtgtatattc acacctagct gcaagaaagg   1320

ctgggattgt attctgtatt ctgggcagtg atgtgtccag ctgagcactg gagttttatt   1380

aataaggaag aaggtatttt cctcctttcc tgaaataatg tgtagttctg accaagtgag   1440

aagaatcata agaatatggg attttgaaaa acatgaaaac atcctaagaa ataccaggaa   1500

ggagtcccac agtgaagcac aaatgaaact caagatgact gcctaaaata agaaatcatg   1560

gatcttagga gaaagggggc aaggaagtaa atcaaaggac aaagctgaag accaagtgga   1620

ccgaaaagaa gatggaatac attttcccaa acactggtgt tctctggagt tggcttatca   1680

acatcttgtg taatagtcat ataattgtcc ctcatttcta tctcctccta aaactagaga   1740

aatggcctat taattttaga aggtgtataa ttatcacaaa gccctcagat taaggtccag   1800

gacacagaat ggaatatatg agcacgcaga aatgtatacc tttagattga acttggatga   1860

tttacctttt gactgtcacc accagcaaat cctgaaattg gatctcttga aacttatggt   1920

tttctttcag cagcatagga gttaagtttt cttctaactt gccctaggtt ctctcaggaa   1980

ctgggaaagc agttctccca aatcccaagt aaggtattca agacaacata aggcagagct   2040

aaattcttct gttgaagaat ttaacatgac tcaaaccata aggaaatcta aagaaggctg   2100

ccaaactatt tcgctgctgc cctcccccac caaaaaagag ataaaaatgt tagatttaca   2160

aagcaaacta cagtgtatgg aatatatata tctatatata gagagatata tatacacaca   2220

cacaattttt ttaacctacc actttgtctt atttgcatga gcacaaatcg ctttcaactt   2280

aatgccagag aaaaaggcaa cattccccgt gatgacttgc tgaaaagctc actgtatttg   2340

tttgataatg gattttagtt cattgtcatg tacttcactc ttcatcagca ggagcacttc   2400

agggtaaaga aacaggcttt taccacactg gaacaaaagc tatataagga aaaaaaaatc   2460

ctgagcagat ggaatattat ttgcatttgc acaaatagtg ctttttagca caattcatat   2520

tactccattg tgagctaaag taagccacat gtgtctacag catgctgcag acgcagaatc   2580

ggctttttgt ttgtcagact cagaggtccc aaccttatga tatctttgta cttgtatatc   2640

cattagtttt atttcagtta cttatcagaa gggaaaagaa aaaaatggca ctatgcagtt   2700

aagaggacca ttgcatggag ggctaaatta actatttttt attttcatga atgaggatca   2760

aataggtttc agatgtctcg acatctatct ggagatctag atgatgatat aaaattaaaa   2820

tgcagaatgt aagtgtaata aaatttgttt ctccatgatt acatt                   2865


<210>  4488
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  4488

Met Lys Gly Thr Ile Leu Ser His Leu Gly Ala Cys Pro Gly Tyr Glu 
1               5                   10                  15      


Lys Gln Val Ser Leu His His Pro Gly Trp Ser Thr Val Val Gln Pro 
            20                  25                  30          


Gln Leu Thr Ala Ser Ser Ala Ser Trp Val Arg Val Ile His Val Pro 
        35                  40                  45              


Gln Pro Pro Lys Lys Leu Glu Leu Gln Thr Leu Pro Asn Asn Ser Arg 
    50                  55                  60                  


Ile His Ile Phe Phe Arg Leu Thr Lys Ser Ile Asn Gln Glu 
65                  70                  75              


<210>  4489
<211>  2865
<212>  DNA
<213>  Homosapiens

<400>  4489
tgccgccagg agtggcagga ggcgagctga gtgaaatgag ctgctccagt tcccgcccac     60

gaagggggtt aagatgaagg gaacaatcct gtctcatctg ggggcctgtc caggatatga    120

aaaacaagta tcactccatc acccaggctg gagcacagtg gtgcaacctc agctcactgc    180

aagctctgcc tcctgggttc gagtgattca tgtgcctcag cctcccaaga agctggaatt    240

acagactcta cccaacaaca gcagaataca cattttcttc aggttgacca agagcattaa    300

ccaagagtaa tcaaaaagag gagccgacta gacacagcca ggaagagctt ctcccaccgg    360

aagaccagac cagcaagaaa gttggcaccc tccaagcagg ttgttgaaag gaaggccttg    420

aatgtggaca gagggcgatg cagatgagga aagactagaa ggttctgtac ctgttaacag    480

tggctgatcc tagaagagtg aaatttaggc aggtagttgg aaagaacaca gcacagaaaa    540

ctttaggatg aattttccta gcagccattc tgtatcgtca aagccttcaa tccctgagga    600

gagagttaat ggcacacagg agtggggtga tttgggcaat gagtgcttct tcctttcaac    660

ctgttgctgc ctaacacaag gacaattggt cttccaccct cttcacagtt cattcagtca    720

ttgtccctgt ctcccaggtg agttgagtga aaataatggt gacaagaagc ccactgcctg    780

attcacataa gcaaggcatg ctgcagggaa gacagggttc ttattaatat ttcctttcat    840

gtgcttacat atgagttaca gttgctaatc ctttcccaca gtttagcacc tagttaaaag    900

aaagggcttc ggaatcaggt aagtgtagat taaagttata acggcaaatt gctgaacctt    960

tggaagcctc ggtttttcca cctggaaaat ggatttttat cttacaggac tgtcgtgagg   1020

attgatgagc taacattcct aaatcaggga gtttgaagtc tggcccagga tcgtctagat   1080

tttgacgttc tccttgtctt tgctgtgtac ccctgggaga aacaaagggt gagaagaaac   1140

aagggaaagg agaaacattt gtgttttcca acttttcagt gttgatcagc cagcgggaat   1200

aaagagaaga tgtgtaagat ggagggcaaa agagattccc agaagctgct gcagatctct   1260

tccagttgca tttcgaaagc cattacttaa gtgtatattc acacctagct gcaagaaagg   1320

ctgggattgt attctgtatt ctgggcagtg atgtgtccag ctgagcactg gagttttatt   1380

aataaggaag aaggtatttt cctcctttcc tgaaataatg tgtagttctg accaagtgag   1440

aagaatcata agaatatggg attttgaaaa acatgaaaac atcctaagaa ataccaggaa   1500

ggagtcccac agtgaagcac aaatgaaact caagatgact gcctaaaata agaaatcatg   1560

gatcttagga gaaagggggc aaggaagtaa atcaaaggac aaagctgaag accaagtgga   1620

ccgaaaagaa gatggaatac attttcccaa acactggtgt tctctggagt tggcttatca   1680

acatcttgtg taatagtcat ataattgtcc ctcatttcta tctcctccta aaactagaga   1740

aatggcctat taattttaga aggtgtataa ttatcacaaa gccctcagat taaggtccag   1800

gacacagaat ggaatatatg agcacgcaga aatgtatacc tttagattga acttggatga   1860

tttacctttt gactgtcacc accagcaaat cctgaaattg gatctcttga aacttatggt   1920

tttctttcag cagcatagga gttaagtttt cttctaactt gccctaggtt ctctcaggaa   1980

ctgggaaagc agttctccca aatcccaagt aaggtattca agacaacata aggcagagct   2040

aaattcttct gttgaagaat ttaacatgac tcaaaccata aggaaatcta aagaaggctg   2100

ccaaactatt tcgctgctgc cctcccccac caaaaaagag ataaaaatgt tagatttaca   2160

aagcaaacta cagtgtatgg aatatatata tctatatata gagagatata tatacacaca   2220

cacaattttt ttaacctacc actttgtctt atttgcatga gcacaaatcg ctttcaactt   2280

aatgccagag aaaaaggcaa cattccccgt gatgacttgc tgaaaagctc actgtatttg   2340

tttgataatg gattttagtt cattgtcatg tacttcactc ttcatcagca ggagcacttc   2400

agggtaaaga aacaggcttt taccacactg gaacaaaagc tatataagga aaaaaaaatc   2460

ctgagcagat ggaatattat ttgcatttgc acaaatagtg ctttttagca caattcatat   2520

tactccattg tgagctaaag taagccacat gtgtctacag catgctgcag acgcagaatc   2580

ggctttttgt ttgtcagact cagaggtccc aaccttatga tatctttgta cttgtatatc   2640

cattagtttt atttcagtta cttatcagaa gggaaaagaa aaaaatggca ctatgcagtt   2700

aagaggacca ttgcatggag ggctaaatta actatttttt attttcatga atgaggatca   2760

aataggtttc agatgtctcg acatctatct ggagatctag atgatgatat aaaattaaaa   2820

tgcagaatgt aagtgtaata aaatttgttt ctccatgatt acatt                   2865


<210>  4490
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  4490

Met Lys Gly Thr Ile Leu Ser His Leu Gly Ala Cys Pro Gly Tyr Glu 
1               5                   10                  15      


Lys Gln Val Ser Leu His His Pro Gly Trp Ser Thr Val Val Gln Pro 
            20                  25                  30          


Gln Leu Thr Ala Ser Ser Ala Ser Trp Val Arg Val Ile His Val Pro 
        35                  40                  45              


Gln Pro Pro Lys Lys Leu Glu Leu Gln Thr Leu Pro Asn Asn Ser Arg 
    50                  55                  60                  


Ile His Ile Phe Phe Arg Leu Thr Lys Ser Ile Asn Gln Glu 
65                  70                  75              


<210>  4491
<211>  3204
<212>  DNA
<213>  Homosapiens

<400>  4491
aagtgagaaa tgctgcttgg tgagctgggc tggctgggct gctggccctc ggtcagccgc     60

ctgcaacagg cagggccacg ggaacctcat cagcagagct tcctggaggc agcgtgggtg    120

gaattgtgga attgtcatca gacaggcctg ggatggagct tccccactgg aacgcagctg    180

gctgtggaca gggagtcagc tgctgcctga agggacaagg aggcctgcga ccacagcagg    240

ttcccacctg gcctgggcct ggaggccagc aggcaccttt cagggcttcc cagctcagcc    300

cccacagctg gatggagctg tgttccctgc agaagtgtgg ccggctccga gcaggcacag    360

ggggctcttt ccctccacct cagccctggc ctatgtgggc acagcagagg acgtgctcac    420

accatggggg cccccgacca ggcgaggcca gggcgtgtcc acattgggga agtgaacgaa    480

gaaggacaag tctatttgag gggctggctg atagtttaga agcccagaat cgcctggcag    540

tgaattattc tgctgagtaa cactgtaccc agagggatgt ggctgaaaac cccgggaggg    600

aaggctgcgt gcgggaagca ctcccatcct cccccagcgc ctgctctggg cgttccggag    660

ctcagcgtgc atccttgcct atgctcacct gtgaagaggg agaacgtcgc tgtccgagca    720

aatgtctctt ctgtgtcctt ggctgccttc ctcctcctcc tcccgccgcc tactttgggg    780

ccccttcctc ttctcagcag tgccactgac cagcccagcc tcatgcacca tcccggccgt    840

tgccctggag ggctggcagc tggcaggact cagagagggc ccagccatca cccctctctt    900

gagcagatga cagagtaaca ctgggagtta ctatggacac tggaaaagag aacacagatg    960

cgtcggagat tttgtagttg caactcttct ctggtaacca aaaaacatca ggacattcat   1020

tgcaagtgca acgctgaggc tttgaaggaa ccaaagagat cctttgcagc cctgaggacg   1080

gagggaggga gggaaaaggg agtggggtgg gagggaggga gggagtccac tgcagaaagt   1140

ggcactgatc cctctgagcc tctccggcct catgtgtaag atgccagctg ccccggagtg   1200

gcagtggcga gtgagtggct gtgtaaggtg cccaggcagg agcttgcggg cagccctgtg   1260

tgaagtgggc agccttgggc cgggttccct agaagcagag ctgagatggg gattcttgtt   1320

catgcgattg gaggtgcttc ctaagaagtt gctccctgcc ccaactccga gccagggcgg   1380

cactgaccat gggcaacttt cccttgcagg gggcactccc agctgccggg gaggggcagt   1440

ggccctgaag gggcctggtc aggaccaaca gttttcttgg cagtggtgtg tttgtcccca   1500

tttcgcagat gaggaaactg aggcttggaa agacccaggt ccttgcccag gccccacacc   1560

acacccagga ggggcggcgc tggagtcctg cgccacgtcg ctgttctcac caggaggagg   1620

cccttgtttg ctgcgtccag cgaccccatc tccatgctgc aggcaggagg acacagccgg   1680

ggctcctgga agcctctcgc gttcctgggc tagggaacct tcctccatct cagagccggc   1740

catggggtgt cccctgacct tccgcagcca tgtccccctt cgatggagct ctgcttctgg   1800

ccctccctcc acactgaagg cccctgtgat cacatggccc acccgccaat ccaggtggcc   1860

tccctccaag gtcagccggt gagctgcctt catgcctgca tggtgtctct gacccttggc   1920

cacgcaacct aacatagtca cagctcctgg agatttgcac tgggatatct tgggtgaggg   1980

gaattattct gctgaccccc gatggcaact gcagtggtgg gaggggaaga gaacaccagg   2040

atgtgttcag agagagaggc gtggacctca gggggtgtca ggggaagagg gcccgggagg   2100

gagaaagcat ttggtttaga cgtgttgggt gtgaggtgcc catggaatag cagggtggag   2160

ctggtggggg aagctggggg gctgccctgg ggctctagca catggaggcc aaggagggag   2220

tcgtggggtg gagggggcac agggctcccc aaggtcctgg gtctgcctca gggccgctgc   2280

tactccacac ccctcctccc atgcctgagc acccatggca gtgaccagca gtgaccatca   2340

tcacccaatg aggatggagg gaaactgagg ctggcctgag atgtcctgag gaatgagctg   2400

gcaccggagt cccacaggtg aaggctgatg aaattctagg agagtccatg tcctaaagga   2460

taagaagcaa ctattcgttg agatgagaga cttcaaagat agtcaatgat cgtgaaagtc   2520

ggccagcctt tctggaccat ctcgtgcaat tgctctaatc tatccctgca atagatccct   2580

ttaatacact ttgtcatatg ttgaattttc tttttagttt ttagttttct tttgttgttg   2640

ttgttgtttt cccatttttt aaaattatta ttattgtgga gacagagtct cactctgtca   2700

cccaggctgg agtgcggggg tgcgatctcg gttcactgca ccctctgcct cccaggttca   2760

agcaattctc ctgcctcagc ctcctgagta gctggggcta caggcacccg ccattatgtc   2820

tggctaattt ttgtattttt agtagagaca gggtttcacc atgttggcca ggctcgtctc   2880

aaactcctga cctcaagtga tccgcccacc tcggcctccc aaagtgttgg gattacaggc   2940

gtgagccacc acacccaggc ccattgtttt taattatcaa cgttattttt gttattctat   3000

gtatttcatc tttgcatgat ttccagtatg ggaggtataa attgtgtaaa gacgttgaga   3060

gttctaattt gttgtatgca ttttttacaa atgtgactcc gtgaaaatga ttatcacaac   3120

attgacttta tgtgtaagcg ttgtgtgtgt gcgtacataa aatcgtcgaa acttcctcaa   3180

taaatgaaga gatgtccttt ttgt                                          3204


<210>  4492
<211>  236
<212>  PRT
<213>  Homosapiens

<400>  4492

Met Cys Lys Met Pro Ala Ala Pro Glu Trp Gln Trp Arg Val Ser Gly 
1               5                   10                  15      


Cys Val Arg Cys Pro Gly Arg Ser Leu Arg Ala Ala Leu Cys Glu Val 
            20                  25                  30          


Gly Ser Leu Gly Pro Gly Ser Leu Glu Ala Glu Leu Arg Trp Gly Phe 
        35                  40                  45              


Leu Phe Met Arg Leu Glu Val Leu Pro Lys Lys Leu Leu Pro Ala Pro 
    50                  55                  60                  


Thr Pro Ser Gln Gly Gly Thr Asp His Gly Gln Leu Ser Leu Ala Gly 
65                  70                  75                  80  


Gly Thr Pro Ser Cys Arg Gly Gly Ala Val Ala Leu Lys Gly Pro Gly 
                85                  90                  95      


Gln Asp Gln Gln Phe Ser Trp Gln Trp Cys Val Cys Pro His Phe Ala 
            100                 105                 110         


Asp Glu Glu Thr Glu Ala Trp Lys Asp Pro Gly Pro Cys Pro Gly Pro 
        115                 120                 125             


Thr Pro His Pro Gly Gly Ala Ala Leu Glu Ser Cys Ala Thr Ser Leu 
    130                 135                 140                 


Phe Ser Pro Gly Gly Gly Pro Cys Leu Leu Arg Pro Ala Thr Pro Ser 
145                 150                 155                 160 


Pro Cys Cys Arg Gln Glu Asp Thr Ala Gly Ala Pro Gly Ser Leu Ser 
                165                 170                 175     


Arg Ser Trp Ala Arg Glu Pro Ser Ser Ile Ser Glu Pro Ala Met Gly 
            180                 185                 190         


Cys Pro Leu Thr Phe Arg Ser His Val Pro Leu Arg Trp Ser Ser Ala 
        195                 200                 205             


Ser Gly Pro Pro Ser Thr Leu Lys Ala Pro Val Ile Thr Trp Pro Thr 
    210                 215                 220                 


Arg Gln Ser Arg Trp Pro Pro Ser Lys Val Ser Arg 
225                 230                 235     


<210>  4493
<211>  855
<212>  DNA
<213>  Homosapiens

<400>  4493
atgcctggat ggttcaaaaa ggcgtggtat gggctggcgt ctttactcag cttctcctcc     60

ttcatcctga tcatcgttgc cctggtagtg ccccactggc tgagtgggaa aatcctttgt    120

cagactggag tggatctggt caacgccaca gacagagagc tggtcaagtt cattggggac    180

atttactacg ggctcttccg agggtgtaaa gtgcggcagt gtgggcttgg gggccgccaa    240

tcccaattca cgagaacaga ggcttgttgg tcaactgaca agcatgaatc tgggggccat    300

gagttcatct cagaaagtct cccgctgttt gaaatcccca cgcttgctgt cttgccctca    360

cccctgtctg tcgaagcctt cgtggtaagc aagcttggac ttcatgaaat cttcccacac    420

ctggtgaagg agctcaacgc aggccttcat gtgatgattc tgctgctcct cttcctggcc    480

ttggccctgg ctctggtcag catgggcttt gccattctta acatgatcca ggtcccgtac    540

cgggcagtca gcggtcctgg gggcatctgc ctatggaatg tcctggcagg cggcgtcgtg    600

gcgttagcca tcgccagctt cgtggctgcg gtgaaatttc acgacctgac ggaacgaatc    660

gccaactttc aggagaagct cttccagttt gtggtggtgg aagaacagta tgaagagtcg    720

ttttggatct gcgtggccag cgcttcggcc catgctgcaa acttggtcgt ggtggcgatc    780

agtcaaattc ccctccctga gattaagacc aaaatcgaag aggccacggt cacagctgag    840

gatatcttgt attaa                                                     855


<210>  4494
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  4494

Met Pro Gly Trp Phe Lys Lys Ala Trp Tyr Gly Leu Ala Ser Leu Leu 
1               5                   10                  15      


Ser Phe Ser Ser Phe Ile Leu Ile Ile Val Ala Leu Val Val Pro His 
            20                  25                  30          


Trp Leu Ser Gly Lys Ile Leu Cys Gln Thr Gly Val Asp Leu Val Asn 
        35                  40                  45              


Ala Thr Asp Arg Glu Leu Val Lys Phe Ile Gly Asp Ile Tyr Tyr Gly 
    50                  55                  60                  


Leu Phe Arg Gly Cys Lys Val Arg Gln Cys Gly Leu Gly Gly Arg Gln 
65                  70                  75                  80  


Ser Gln Phe Thr Arg Thr Glu Ala Cys Trp Ser Thr Asp Lys His Glu 
                85                  90                  95      


Ser Gly Gly His Glu Phe Ile Ser Glu Ser Leu Pro Leu Phe Glu Ile 
            100                 105                 110         


Pro Thr Leu Ala Val Leu Pro Ser Pro Leu Ser Val Glu Ala Phe Val 
        115                 120                 125             


Val Ser Lys Leu Gly Leu His Glu Ile Phe Pro His Leu Val Lys Glu 
    130                 135                 140                 


Leu Asn Ala Gly Leu His Val Met Ile Leu Leu Leu Leu Phe Leu Ala 
145                 150                 155                 160 


Leu Ala Leu Ala Leu Val Ser Met Gly Phe Ala Ile Leu Asn Met Ile 
                165                 170                 175     


Gln Val Pro Tyr Arg Ala Val Ser Gly Pro Gly Gly Ile Cys Leu Trp 
            180                 185                 190         


Asn Val Leu Ala Gly Gly Val Val Ala Leu Ala Ile Ala Ser Phe Val 
        195                 200                 205             


Ala Ala Val Lys Phe His Asp Leu Thr Glu Arg Ile Ala Asn Phe Gln 
    210                 215                 220                 


Glu Lys Leu Phe Gln Phe Val Val Val Glu Glu Gln Tyr Glu Glu Ser 
225                 230                 235                 240 


Phe Trp Ile Cys Val Ala Ser Ala Ser Ala His Ala Ala Asn Leu Val 
                245                 250                 255     


Val Val Ala Ile Ser Gln Ile Pro Leu Pro Glu Ile Lys Thr Lys Ile 
            260                 265                 270         


Glu Glu Ala Thr Val Thr Ala Glu Asp Ile Leu Tyr 
        275                 280                 


<210>  4495
<211>  855
<212>  DNA
<213>  Homosapiens

<400>  4495
atgcctggat ggttcaaaaa ggcgtggtat gggctggcgt ctttactcag cttctcctcc     60

ttcatcctga tcatcgttgc cctggtagtg ccccactggc tgagtgggaa aatcctttgt    120

cagactggag tggatctggt caacgccaca gacagagagc tggtcaagtt cattggggac    180

atttactacg ggctcttccg agggtgtaag gtgcggcagt gtgggcttgg gggccgccaa    240

tcccaattca cgagaacaga ggcttgttgg tcaactgaca agcatgaatc tgggggccat    300

gagttcatct cagaaagtct cccgctgttt gaaatcccca cgcttgctgt cttgccctca    360

cccctgtctg tcgaagcctt cgtggtaagc aagcttggac ttcatgaaat cttcccacac    420

ctggtgaagg agctcaacgc aggccttcat gtgatgattc tgctgctcct cttcctggcc    480

ttggccctgg ctctggtcag catgggcttt gccattctta acatgatcca ggtcccgtac    540

cgggcagtca gcggtcctgg gggcatctgc ctatggaatg tcctggcagg cggcgtcgtg    600

gcgttagcca tcgccagctt cgtggctgcg gtgaaatttc acgacctgac ggaacgaatc    660

gccaactttc aggagaagct cttccagttt gtggtggtgg aagaacagta tgaagagtcg    720

ttttggatct gcgtggccag cgcttcggcc catgctgcaa acttggtcgt ggtggcgatc    780

agtcaaattc ccctccctga gattaagacc aaaatcgaag aggccacggt cacagctgag    840

gatatcttgt attaa                                                     855


<210>  4496
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  4496

Met Pro Gly Trp Phe Lys Lys Ala Trp Tyr Gly Leu Ala Ser Leu Leu 
1               5                   10                  15      


Ser Phe Ser Ser Phe Ile Leu Ile Ile Val Ala Leu Val Val Pro His 
            20                  25                  30          


Trp Leu Ser Gly Lys Ile Leu Cys Gln Thr Gly Val Asp Leu Val Asn 
        35                  40                  45              


Ala Thr Asp Arg Glu Leu Val Lys Phe Ile Gly Asp Ile Tyr Tyr Gly 
    50                  55                  60                  


Leu Phe Arg Gly Cys Lys Val Arg Gln Cys Gly Leu Gly Gly Arg Gln 
65                  70                  75                  80  


Ser Gln Phe Thr Arg Thr Glu Ala Cys Trp Ser Thr Asp Lys His Glu 
                85                  90                  95      


Ser Gly Gly His Glu Phe Ile Ser Glu Ser Leu Pro Leu Phe Glu Ile 
            100                 105                 110         


Pro Thr Leu Ala Val Leu Pro Ser Pro Leu Ser Val Glu Ala Phe Val 
        115                 120                 125             


Val Ser Lys Leu Gly Leu His Glu Ile Phe Pro His Leu Val Lys Glu 
    130                 135                 140                 


Leu Asn Ala Gly Leu His Val Met Ile Leu Leu Leu Leu Phe Leu Ala 
145                 150                 155                 160 


Leu Ala Leu Ala Leu Val Ser Met Gly Phe Ala Ile Leu Asn Met Ile 
                165                 170                 175     


Gln Val Pro Tyr Arg Ala Val Ser Gly Pro Gly Gly Ile Cys Leu Trp 
            180                 185                 190         


Asn Val Leu Ala Gly Gly Val Val Ala Leu Ala Ile Ala Ser Phe Val 
        195                 200                 205             


Ala Ala Val Lys Phe His Asp Leu Thr Glu Arg Ile Ala Asn Phe Gln 
    210                 215                 220                 


Glu Lys Leu Phe Gln Phe Val Val Val Glu Glu Gln Tyr Glu Glu Ser 
225                 230                 235                 240 


Phe Trp Ile Cys Val Ala Ser Ala Ser Ala His Ala Ala Asn Leu Val 
                245                 250                 255     


Val Val Ala Ile Ser Gln Ile Pro Leu Pro Glu Ile Lys Thr Lys Ile 
            260                 265                 270         


Glu Glu Ala Thr Val Thr Ala Glu Asp Ile Leu Tyr 
        275                 280                 


<210>  4497
<211>  309
<212>  DNA
<213>  Homosapiens

<400>  4497
atgaactctg tattctctcg aagtctcatc ccagtctgtg ggccgtatac tcggcactct     60

gagactgagc tatgggacat gtgggcaggg atccgcaaca acgatgggaa cttagtcatt    120

gacagtctgt tacagtacat caatcggagg aagaagttta gaaggcactg ggtgggagct    180

cttgcctctg taactatccc cattcatttt atctatgggc cattggatcc tgtgaacccc    240

tatccagggt ttttggagct gtacaggaaa atgctgctgt ggtccacatt agccacgatc    300

tacagctag                                                            309


<210>  4498
<211>  102
<212>  PRT
<213>  Homosapiens

<400>  4498

Met Asn Ser Val Phe Ser Arg Ser Leu Ile Pro Val Cys Gly Pro Tyr 
1               5                   10                  15      


Thr Arg His Ser Glu Thr Glu Leu Trp Asp Met Trp Ala Gly Ile Arg 
            20                  25                  30          


Asn Asn Asp Gly Asn Leu Val Ile Asp Ser Leu Leu Gln Tyr Ile Asn 
        35                  40                  45              


Arg Arg Lys Lys Phe Arg Arg His Trp Val Gly Ala Leu Ala Ser Val 
    50                  55                  60                  


Thr Ile Pro Ile His Phe Ile Tyr Gly Pro Leu Asp Pro Val Asn Pro 
65                  70                  75                  80  


Tyr Pro Gly Phe Leu Glu Leu Tyr Arg Lys Met Leu Leu Trp Ser Thr 
                85                  90                  95      


Leu Ala Thr Ile Tyr Ser 
            100         


<210>  4499
<211>  1882
<212>  DNA
<213>  Homosapiens

<400>  4499
atgtcgacaa agatctggag caactggaat cttcacacat tgctgacagg aatctctcct     60

ccacccaatc tccggtttgc aactttaccg tcgggtgttg acgggaaggg ggtgtgggag    120

cggggtgggt gggaagagtc cccgcgcccc tccccgcccg gtctgacccg gcctggcctc    180

acttcctccc gcggccgcgc ggcctcccgg cagtgcccga gcccggcccg cgggtaccgc    240

ccagaaggcg aaggcgccac caccgccgca gctggccctc tggctcccac atccggactc    300

accggcagct ccagccgccg ttgcctccgc ctccagccgc attgccctca ggcctcgagt    360

cccccactag ctccttccgt ccaggcacgg gctccggcgc tagagcagtt tgaaaatggc    420

gcggagggac gatcggggcc gacacggagg aggcgccgcg gttgccccgg taacgggagc    480

ggcggacgat tagcggctcg cggcggggac gcgcttggcg acgatggcgg agccccagtg    540

cccggaaatg caacggcccg gacagcgcga ggccacggcg ccccctggag gtcggcgccc    600

gcggccagca aatgccaaac ctcagctggt gcctgagctg gcatcctctt cctcctgtcg    660

gcgggaggtg tggatcacct actgcgtgcg gggaacaaac gccgccccag taccggtccc    720

tgcagcggag tagccttcac ctgcaaggtg aacgcctgct caccacgtaa tccccaaacg    780

cagatatcac gttgtctctg caactttccc tgacaaccac ccaatgcaat taattatccc    840

acaatagtat ctcccgcagg ctctctgtag aaccatagaa ttcatccatc aaaatacaat    900

catttgttga tccgtctctc tctgccgccc ccaaatgtga attccttgag tcagagacta    960

ttctactcag caaaacattt gtgagtggaa ttaaattgaa ataaaccgtt atagtccact   1020

cacagatgga aaacacatag taaaatccta gaattccatt tctcccctga aaatttccca   1080

gacagtcaga gggagtttca ttctttcctg tttacttttc tcccaaatag gccttctgag   1140

gcagcagaat agggaaggaa gtcagaagac tgaccagctc atacctatgg aatgcctatc   1200

atacatacac ttaaaattat ggcaagctca cgcaggcgca ctaagagaga aaaaacaaga   1260

aaacagatat gacaattata ggaaatcccc tccctagagt taaagaagtg taggaagtgg   1320

gtataaaaga acaaaggcta tattaatcca gggctgacac cacttgaaga taagcccgtt   1380

cctctctctg gtatattctt tgcttaataa atcttgtggg gtggttattt gtgtgtctca   1440

tccaattctt tgttcataac accaagaacc tggaactccc aacttccaat ctggtaacat   1500

attttggtga gccagccagg agggtcaagc ctgcaatacc taaagctcca gacctggaac   1560

ccaaagctcc catcagtcgc taccctgtga acctgtggag gatctgaagt acctgtttaa   1620

aaggcatcca aaagatagaa tctatcaagc tacaaatggc tatgttgcct gaagccccag   1680

acatcatcct acaagaaata agtccagact tcttaatttc cccctggata gagcagggtg   1740

atactgtggc ctgggtgaag acatcgtatc ctctgtgtgt aacagtgata agaaggctta   1800

cctcgcaggg ttattacaag acaaatgaaa taactttggc acactattaa aggcttcgtg   1860

gataattaaa gcttcacaaa aa                                            1882


<210>  4500
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  4500

Met Ser Thr Lys Ile Trp Ser Asn Trp Asn Leu His Thr Leu Leu Thr 
1               5                   10                  15      


Gly Ile Ser Pro Pro Pro Asn Leu Arg Phe Ala Thr Leu Pro Ser Gly 
            20                  25                  30          


Val Asp Gly Lys Gly Val Trp Glu Arg Gly Gly Trp Glu Glu Ser Pro 
        35                  40                  45              


Arg Pro Ser Pro Pro Gly Leu Thr Arg Pro Gly Leu Thr Ser Ser Arg 
    50                  55                  60                  


Gly Arg Ala Ala Ser Arg Gln Cys Pro Ser Pro Ala Arg Gly Tyr Arg 
65                  70                  75                  80  


Pro Glu Gly Glu Gly Ala Thr Thr Ala Ala Ala Gly Pro Leu Ala Pro 
                85                  90                  95      


Thr Ser Gly Leu Thr Gly Ser Ser Ser Arg Arg Cys Leu Arg Leu Gln 
            100                 105                 110         


Pro His Cys Pro Gln Ala Ser Ser Pro Pro Leu Ala Pro Ser Val Gln 
        115                 120                 125             


Ala Arg Ala Pro Ala Leu Glu Gln Phe Glu Asn Gly Ala Glu Gly Arg 
    130                 135                 140                 


Ser Gly Pro Thr Arg Arg Arg Arg Arg Gly Cys Pro Gly Asn Gly Ser 
145                 150                 155                 160 


Gly Gly Arg Leu Ala Ala Arg Gly Gly Asp Ala Leu Gly Asp Asp Gly 
                165                 170                 175     


Gly Ala Pro Val Pro Gly Asn Ala Thr Ala Arg Thr Ala Arg Gly His 
            180                 185                 190         


Gly Ala Pro Trp Arg Ser Ala Pro Ala Ala Ser Lys Cys Gln Thr Ser 
        195                 200                 205             


Ala Gly Ala 
    210     


<210>  4501
<211>  1882
<212>  DNA
<213>  Homosapiens

<400>  4501
atgtcgacaa agatctggag caactggaat cttcacacat tgctgacagg aatctctcct     60

ccacccaatc tccggtttgc aactttaccg tcgggtgttg acgggaaggg ggtgtgggag    120

cggggtgggt gggaagagtc cccgcgcccc tccccgcccg gtctgacccg gcctggcctc    180

acttcctccc gcggccgcgc ggcctcccgg cagtgcccga gcccggcccg cgggtaccgc    240

ccagaaggcg aaggcgccac caccgccgca gctggccctc tggctcccac atccggactc    300

accggcagct ccagccgccg ttgcctccgc ctccagccgc attgccctca ggcctcgagt    360

cccccactag ctccttccgt ccaggcacgg gctccggcgc tagagcagtt tgaaaatggc    420

gcggagggac gatcggggcc gacacggagg aggcgccgcg gttgccccgg taacgggagc    480

ggcggacgat tagcggctcg cggcggggac gcgcttggcg acgatggcgg agccccagtg    540

cccggaaatg caacggcccg gacagcgcga ggccacggcg ccccctggag gtcggcgccc    600

gcggccagca aatgccaaac ctcagctggt gcctgagctg gcatcctctt cctcctgtcg    660

gcgggaggtg tggatcacct actgcgtgcg gggaacaaac gccgccccag taccggtccc    720

tgcagcggag tagccttcac ctgcaaggtg aacgcctgct caccacgtaa tccccaaacg    780

cagatatcac gttgtctctg caactttccc tgacaaccac ccaatgcaat taattatccc    840

acaatagtat ctcccgcagg ctctctgtag aaccatagaa ttcatccatc aaaatacaat    900

catttgttga tccgtctctc tctgccgccc ccaaatgtga attccttgag tcagagacta    960

ttctactcag caaaacattt gtgagtggaa ttaaattgaa ataaaccgtt atagtccact   1020

cacagatgga aaacacatag taaaatccta gaattccatt tctcccctga aaatttccca   1080

gacagtcaga gggagtttca ttctttcctg tttacttttc tcccaaatag gccttctgag   1140

gcagcagaat agggaaggaa gtcagaagac tgaccagctc atacctatgg aatgcctatc   1200

atacatacac ttaaaattat ggcaagctca cgcaggcgca ctaagagaga aaaaacaaga   1260

aaacagatat gacaattata ggaaatcccc tccctagagt taaagaagtg taggaagtgg   1320

gtataaaaga acaaaggcta tattaatcca gggctgacac cacttgaaga taagcccgtt   1380

cctctctctg gtatattctt tgcttaataa attttgtggg gtggttattt gtgtgtctca   1440

tccaattctt tgttcataac accaagaacc tggaactccc aacttccaat ctggtaacat   1500

attttggtga gccagccagg agggtcaagc ctgcaatacc taaagctcca gacctggaac   1560

ccaaagctcc catcagtcgc taccctgtga acctgtggag gatctgaagt acctgtttaa   1620

aaggcatcca aaagatagaa tctatcaagc tacaaatggc tatgttgcct gaagccccag   1680

acatcatcct acaagaaata agtccagact tcttaatttc cccctggata gagcagggtg   1740

atactgtggc ctgggtgaag acatcgtatc ctctgtgtgt aacagtgata agaaggctta   1800

cctcgcaggg ttattacaag acaaatgaaa taactttggc acactattaa aggcttcgtg   1860

gataattaaa gcttcacaaa aa                                            1882


<210>  4502
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  4502

Met Ser Thr Lys Ile Trp Ser Asn Trp Asn Leu His Thr Leu Leu Thr 
1               5                   10                  15      


Gly Ile Ser Pro Pro Pro Asn Leu Arg Phe Ala Thr Leu Pro Ser Gly 
            20                  25                  30          


Val Asp Gly Lys Gly Val Trp Glu Arg Gly Gly Trp Glu Glu Ser Pro 
        35                  40                  45              


Arg Pro Ser Pro Pro Gly Leu Thr Arg Pro Gly Leu Thr Ser Ser Arg 
    50                  55                  60                  


Gly Arg Ala Ala Ser Arg Gln Cys Pro Ser Pro Ala Arg Gly Tyr Arg 
65                  70                  75                  80  


Pro Glu Gly Glu Gly Ala Thr Thr Ala Ala Ala Gly Pro Leu Ala Pro 
                85                  90                  95      


Thr Ser Gly Leu Thr Gly Ser Ser Ser Arg Arg Cys Leu Arg Leu Gln 
            100                 105                 110         


Pro His Cys Pro Gln Ala Ser Ser Pro Pro Leu Ala Pro Ser Val Gln 
        115                 120                 125             


Ala Arg Ala Pro Ala Leu Glu Gln Phe Glu Asn Gly Ala Glu Gly Arg 
    130                 135                 140                 


Ser Gly Pro Thr Arg Arg Arg Arg Arg Gly Cys Pro Gly Asn Gly Ser 
145                 150                 155                 160 


Gly Gly Arg Leu Ala Ala Arg Gly Gly Asp Ala Leu Gly Asp Asp Gly 
                165                 170                 175     


Gly Ala Pro Val Pro Gly Asn Ala Thr Ala Arg Thr Ala Arg Gly His 
            180                 185                 190         


Gly Ala Pro Trp Arg Ser Ala Pro Ala Ala Ser Lys Cys Gln Thr Ser 
        195                 200                 205             


Ala Gly Ala 
    210     


<210>  4503
<211>  483
<212>  DNA
<213>  Homosapiens

<400>  4503
atggggacag gggcgggctt ctctcctcca ctcgcgcccc tccgggccgg gcccccgcag     60

cgccccggga ctccagggga cctggccccg ggggcgtggg ctcggcgcgg cgggcggtgg    120

gcttcggggc ggtgtcccca tgtgggaggc gcggaccctc ccggaggaac ctgcgcgcgg    180

cttgcgcgct ttggatcccc gcaggggaac ctgccgccgg gctgcacccc gggaacttgc    240

ggagaatatg ggacctcgcc tgccttctcc tcttcccgcg cctcgccatc ctgtccccag    300

gtccctggct cggtcccgac cgcggcaagg gccagaacca gacctcaccg tccgggatcg    360

cggacgccgt ccgggctcag ccctctcccc accgcccccg gagctgcatt gctttgttta    420

acctctgcca gaccgtttcg cacaaactct tgttgcccca attctgatga gccaccagtt    480

tga                                                                  483


<210>  4504
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  4504

Met Gly Thr Gly Ala Gly Phe Ser Pro Pro Leu Ala Pro Leu Arg Ala 
1               5                   10                  15      


Gly Pro Pro Gln Arg Pro Gly Thr Pro Gly Asp Leu Ala Pro Gly Ala 
            20                  25                  30          


Trp Ala Arg Arg Gly Gly Arg Trp Ala Ser Gly Arg Cys Pro His Val 
        35                  40                  45              


Gly Gly Ala Asp Pro Pro Gly Gly Thr Cys Ala Arg Leu Ala Arg Phe 
    50                  55                  60                  


Gly Ser Pro Gln Gly Asn Leu Pro Pro Gly Cys Thr Pro Gly Thr Cys 
65                  70                  75                  80  


Gly Glu Tyr Gly Thr Ser Pro Ala Phe Ser Ser Ser Arg Ala Ser Pro 
                85                  90                  95      


Ser Cys Pro Gln Val Pro Gly Ser Val Pro Thr Ala Ala Arg Ala Arg 
            100                 105                 110         


Thr Arg Pro His Arg Pro Gly Ser Arg Thr Pro Ser Gly Leu Ser Pro 
        115                 120                 125             


Leu Pro Thr Ala Pro Gly Ala Ala Leu Leu Cys Leu Thr Ser Ala Arg 
    130                 135                 140                 


Pro Phe Arg Thr Asn Ser Cys Cys Pro Asn Ser Asp Glu Pro Pro Val 
145                 150                 155                 160 


<210>  4505
<211>  457
<212>  DNA
<213>  Homosapiens

<400>  4505
gggagcctgg gaatggtggg gttcagtttg ggactggcaa tccagtgcat aaaggacacc     60

ctagaagtct cgtgttgcac ctcgggggac cctgctgggg cccaaaagcc agggcttgga    120

tcttcctctg atagttctac ttcattctgt caaagatcca attcccgaaa gagttttttt    180

catcatcttc aaacatccag aattggctca cacaattaca gaggctgaga ggccatacta    240

tctgtcatgt gcatgcagga gaaccaggaa tgctggtggt gtaattcagt acaagtcaga    300

agacctggga accagggagc tgatggtgcc ctcagtgtat tggatgatac ctgccaatac    360

tggaaaggcc atgtgaccac acaccaagaa gctagctgtc tgccagccag gaagagagcc    420

ctgaccagta atcaaattgg ctgaagactt gatcttg                             457


<210>  4506
<211>  65
<212>  PRT
<213>  Homosapiens

<400>  4506

Met Cys Met Gln Glu Asn Gln Glu Cys Trp Trp Cys Asn Ser Val Gln 
1               5                   10                  15      


Val Arg Arg Pro Gly Asn Gln Gly Ala Asp Gly Ala Leu Ser Val Leu 
            20                  25                  30          


Asp Asp Thr Cys Gln Tyr Trp Lys Gly His Val Thr Thr His Gln Glu 
        35                  40                  45              


Ala Ser Cys Leu Pro Ala Arg Lys Arg Ala Leu Thr Ser Asn Gln Ile 
    50                  55                  60                  


Gly 
65  


<210>  4507
<211>  534
<212>  DNA
<213>  Homosapiens

<400>  4507
atgaaaaccc ctgcggctgc gacgcagacg cccactttgc ccaggccttc acagagcccc     60

aaaccggaac cgccgggaaa acgactgcca accggccaca cgacccaggc agagacgcgg    120

ggagaggctg accagaagaa aggccgacgt gcaagaaacc caccctccgg cgcacagggc    180

acacgtgtcc caaggcacac gaacacacag acggacagag agagaaagag agggcagctc    240

ctgaagttgc cgggttctga tctccgcgac tacgagccac cggagagaga gcagcccacg    300

ggcacacagg cagacctgtc ctcgacatca caagggcgcc acttttgggg agactcaccc    360

gcacaccgtc cgcgcaagcc tgaggctggg atcccgcgct gcgtccccgg cgatctgtct    420

caggtttctt cctcctggcg tttcttcctg ctggtggagc ctccgcgcat cccggcctcc    480

ggagaccgtc ctggtaactg ccctggccag gactggtctc agccccgact ctga          534


<210>  4508
<211>  177
<212>  PRT
<213>  Homosapiens

<400>  4508

Met Lys Thr Pro Ala Ala Ala Thr Gln Thr Pro Thr Leu Pro Arg Pro 
1               5                   10                  15      


Ser Gln Ser Pro Lys Pro Glu Pro Pro Gly Lys Arg Leu Pro Thr Gly 
            20                  25                  30          


His Thr Thr Gln Ala Glu Thr Arg Gly Glu Ala Asp Gln Lys Lys Gly 
        35                  40                  45              


Arg Arg Ala Arg Asn Pro Pro Ser Gly Ala Gln Gly Thr Arg Val Pro 
    50                  55                  60                  


Arg His Thr Asn Thr Gln Thr Asp Arg Glu Arg Lys Arg Gly Gln Leu 
65                  70                  75                  80  


Leu Lys Leu Pro Gly Ser Asp Leu Arg Asp Tyr Glu Pro Pro Glu Arg 
                85                  90                  95      


Glu Gln Pro Thr Gly Thr Gln Ala Asp Leu Ser Ser Thr Ser Gln Gly 
            100                 105                 110         


Arg His Phe Trp Gly Asp Ser Pro Ala His Arg Pro Arg Lys Pro Glu 
        115                 120                 125             


Ala Gly Ile Pro Arg Cys Val Pro Gly Asp Leu Ser Gln Val Ser Ser 
    130                 135                 140                 


Ser Trp Arg Phe Phe Leu Leu Val Glu Pro Pro Arg Ile Pro Ala Ser 
145                 150                 155                 160 


Gly Asp Arg Pro Gly Asn Cys Pro Gly Gln Asp Trp Ser Gln Pro Arg 
                165                 170                 175     


Leu 
    


<210>  4509
<211>  796
<212>  DNA
<213>  Homosapiens

<400>  4509
gtgagaagaa gcaatcagaa gattggcagg atttaggaat ctatttgaaa tattcattac     60

ctattttgaa ttggtcttaa aaatttaaag aaatataaag ctggataatt aaagataaat    120

aataaaggaa gaatacaagg tttctatgct gtgaagcaac tgagattatt atgattttgg    180

ggcagtgaat ttgtttctag aagttttgtt ggaactaagg cagaaaggaa gaagaacaaa    240

tgaccttgga atgaaaaact ttaagttact ccacctaacc actatgaatg atagtcttgt    300

ctcaccaacc ccagcccatc atctgttgga cttggagctc acactttaaa aaagaagatc    360

attctaactg cccctcatga ctactgaaga ggctatgcct gaaaaagcaa aatgtcctac    420

attagagatc accaagcaag acttttttca agaagcaaaa actctcattg cccaacatta    480

tgagaaaata aatgagaata aagttcaagg tacttctata aatgttttta gaaagaaaca    540

ccaaaaaccg aaatctggca aatacatacc tttggagatt gacaaaaagg taacacgtga    600

tgtggtgcaa gaacatcggg ccgcactcag aaggatttgc tttcccaagg agctttccaa    660

aagcgagcat cttcaggaac ccccacaacg aatctccttc aaggaaccac acatttttag    720

tagaagagaa agatgcaggc ccatagatct aattacaaaa gttatggaag cgggaaatcc    780

aagatcaagg tactaa                                                    796


<210>  4510
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  4510

Met Thr Thr Glu Glu Ala Met Pro Glu Lys Ala Lys Cys Pro Thr Leu 
1               5                   10                  15      


Glu Ile Thr Lys Gln Asp Phe Phe Gln Glu Ala Lys Thr Leu Ile Ala 
            20                  25                  30          


Gln His Tyr Glu Lys Ile Asn Glu Asn Lys Val Gln Gly Thr Ser Ile 
        35                  40                  45              


Asn Val Phe Arg Lys Lys His Gln Lys Pro Lys Ser Gly Lys Tyr Ile 
    50                  55                  60                  


Pro Leu Glu Ile Asp Lys Lys Val Thr Arg Asp Val Val Gln Glu His 
65                  70                  75                  80  


Arg Ala Ala Leu Arg Arg Ile Cys Phe Pro Lys Glu Leu Ser Lys Ser 
                85                  90                  95      


Glu His Leu Gln Glu Pro Pro Gln Arg Ile Ser Phe Lys Glu Pro His 
            100                 105                 110         


Ile Phe Ser Arg Arg Glu Arg Cys Arg Pro Ile Asp Leu Ile Thr Lys 
        115                 120                 125             


Val Met Glu Ala Gly Asn Pro Arg Ser Arg Tyr 
    130                 135                 


<210>  4511
<211>  595
<212>  DNA
<213>  Homosapiens

<400>  4511
atggcatggg ctgatctacc cagtcagcaa ggccagattg cagagaaact cagagtctag     60

gaaaatgaat gtctaggaac attcctcaaa tagtcctacc agaagacaca aagatgatgc    120

atccggatga agaatatatc actgagatta atggccctgg gttgcagcca aaagcatctc    180

agaggtagaa cactgttgca gatggtgatg ttaccatttg aaaggtatga tgcatttcct    240

gactgtggtc ggctttccat gggtgaaaca gaaaagtctt caaatatcct caccaactgc    300

tttcctagat ttttcagcca gttacttgac catattagga aaagaaaggt gagcttgggc    360

ttcaggacat agaaaacaac attagttatg ctggaaagta tcaccaaaga agtgcagctc    420

agacaagctg tattctattt tgttcttttg aacataaaca cctataaagg gaccaaaaga    480

aatctaaatg atcaacggga gcaatcctga ataggcaaca acaatcatta ttgccaagtg    540

attgtcttat catttgtcat cagttttttt ttcagagtaa ttacatttaa atgta         595


<210>  4512
<211>  81
<212>  PRT
<213>  Homosapiens

<400>  4512

Met Lys Asn Ile Ser Leu Arg Leu Met Ala Leu Gly Cys Ser Gln Lys 
1               5                   10                  15      


His Leu Arg Gly Arg Thr Leu Leu Gln Met Val Met Leu Pro Phe Glu 
            20                  25                  30          


Arg Tyr Asp Ala Phe Pro Asp Cys Gly Arg Leu Ser Met Gly Glu Thr 
        35                  40                  45              


Glu Lys Ser Ser Asn Ile Leu Thr Asn Cys Phe Pro Arg Phe Phe Ser 
    50                  55                  60                  


Gln Leu Leu Asp His Ile Arg Lys Arg Lys Val Ser Leu Gly Phe Arg 
65                  70                  75                  80  


Thr 
    


<210>  4513
<211>  2094
<212>  DNA
<213>  Homosapiens

<400>  4513
catgatccgc ccaccttggc ctcccaaagt gctgggatta caggcatgag ccaccactcc     60

tggcctcaac ttctatctaa ttctattcag agggaaaatt tctagaagcg acattcctgt    120

tgcagagaag agatattcac ttgagaacct tgatatatat ttgccaaatt tctgtccaag    180

tatcattttt aaaaagttaa aaatatgact ttcatagaaa cacatacaga gcatatgtca    240

aagatgtatt tctctaatgc aatgagacag ccagcaagac agtgaggctg cagcagcatg    300

gggacagagt gcagaaagag gtcgcagaag ccttggaaga aggtcattca gtcatacaag    360

gacaccctga tgcttgcgct gcggtccttt ccaagtccac ggggcattgt tcctttgtgt    420

caacaccaga taagattcat gggcattgct gtcagtgttg tgtgtgttat aataccaggg    480

accctcacat ggctgtgtta gattctaacc aatagacaat aataagtcaa agcaaagacc    540

gttactgatt ccttccattg tttctttaga gactttggtt tagcgctctg aactttctga    600

ttatcagatc ttatgtgttt gctaatatat aaaataacaa attagacata atgccctata    660

attttctcag tttgattaat tgcctgaaat ttgatgtgtc agtcagtgtt tgattagaat    720

agagaaatca catgtaattt gaacaaggaa agattaatac gaagaattgc tagctataac    780

agggttttgg agcaataagg attggctagt aaaaagtaaa gagaactcta aggaatataa    840

gaataacaga taaaaggagc atcaacccct ggggttgaga tacaacgtcc agggcctctg    900

ggattaagat ccagactctg tttgaggggg catggctgtc gctcactgaa tgaagagaag    960

ttgctgtggt agaaatctgt ctcatcagaa tcactctgct ataatactgc cttgtggagg   1020

tactggtgga agatactcgg tgctgctgac tgctgtgcac ttcaggggcc tgacaatgga   1080

gcaaactgca tgggttctgg atctggacac tggagaagct gtgttgcagt acagaagcct   1140

gccaagagga gcacacaaga ctcttggaaa gaagaggaaa atctcctctt acaatgtcaa   1200

tctaacatca tgccagctag caaaggaaaa atgtttaaag ggtccaagtt catttctgca   1260

gagcagacat gaaaggttga attcggagct gagagacaat aagtggacaa ctggcacatt   1320

tggtcaaact tgtaatttta tatcttagat ggacaaatta aacacaagtc cataggtgtt   1380

ttccttacaa gcttacattt aaatttggga tcctggtcag aattttgctg aggacttcaa   1440

tttttcccag tgtttcagga aggataccgt ggggccagag ccacttttct ttattgtaag   1500

gtcctgggct gtggcccctt ttgcttttct gggctccttt ctcatgggca tctgttttgg   1560

gagcttcatt tcctcatctg ctttgacact ttaatcttgg acattgtagt gaaatgcttc   1620

acattgtcac acattctaat ctcagagacc actccaaatc ttttagaatt ttcttggcca   1680

ttggaattag tactctggaa tcagtacatt aggaatggtt ttttaaaaac tatcagctag   1740

aatttcaata ttttagaaga aatggtcagt ataaatttgg agaagcggtt tctagctagt   1800

agtagctgtg cagaaaaaca gttttattga taagtatctg atttggattt aggaaccagc   1860

taggatgaaa aattcaattg aggtctggcc agatagacat aaattttatt tttcctttat   1920

attctgtgtc caaaagacaa attgtcatga gttatttatt ttcttttctg aagtatccat   1980

ttgtttctca gctttggaat tagaggtgta gaaaataaac gggactcaac agcctaagat   2040

tttgtttaaa aagatgttct tatttattta tattaaaaaa atttataaaa attt         2094


<210>  4514
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  4514

Met Lys Arg Ser Cys Cys Gly Arg Asn Leu Ser His Gln Asn His Ser 
1               5                   10                  15      


Ala Ile Ile Leu Pro Cys Gly Gly Thr Gly Gly Arg Tyr Ser Val Leu 
            20                  25                  30          


Leu Thr Ala Val His Phe Arg Gly Leu Thr Met Glu Gln Thr Ala Trp 
        35                  40                  45              


Val Leu Asp Leu Asp Thr Gly Glu Ala Val Leu Gln Tyr Arg Ser Leu 
    50                  55                  60                  


Pro Arg Gly Ala His Lys Thr Leu Gly Lys Lys Arg Lys Ile Ser Ser 
65                  70                  75                  80  


Tyr Asn Val Asn Leu Thr Ser Cys Gln Leu Ala Lys Glu Lys Cys Leu 
                85                  90                  95      


Lys Gly Pro Ser Ser Phe Leu Gln Ser Arg His Glu Arg Leu Asn Ser 
            100                 105                 110         


Glu Leu Arg Asp Asn Lys Trp Thr Thr Gly Thr Phe Gly Gln Thr Cys 
        115                 120                 125             


Asn Phe Ile Ser 
    130         


<210>  4515
<211>  3014
<212>  DNA
<213>  Homosapiens

<400>  4515
ttatatggtt tggctctgtc cccacccaaa tctcatcttg aattgtaaca attcccatgt     60

gtcaagggtg gggccaggtg gagataactg aatcatggag gcagtttccc ccatgctgtt    120

ctcatggtag tgaataagtc tcatgaggtc tgatggtttt ataaatggat gttcccctgc    180

acatgctctc tcctgcccac catgtctgac taaattttgt atttttacta gagacggggt    240

ttcactatgt tggccaggct ggcctccaac tcctgatctc gtgatccgtc caccccgacc    300

tcccaaagtg ctaggattat aggcataagc caccacaccc ggcctctttt ttttcttttt    360

ctttttttta tctggagact gagttttgca ctcgttgccc aggctggagt gcaatggtgc    420

gatctcagct cactgcagtc tccacctcag caggagagca ggaatcttca gtgatccacg    480

ggcagatctg cagccattgt gggcacctgt tcctcccgcg acctttgtgc ccacgtctct    540

ccctccagta cctattgcac gacccccccc acgtccgcct cctgccattg ccagcaagtg    600

ccttgcgcgg gtacctggct gcgcttatta atccattatg gtcgctctgt cactggtgcc    660

attatgtgct cacatgccca ctccctcagg tttagaagtc gcgtcgcccg gcaacagaac    720

aatctgctgg cttagccttt ggccaagttg gcagctggac gaggacgctc agagcccagc    780

tctcgagagt tcaagtatcc gacagttccc cactgctccc aggagcggtt acccgggcac    840

tctgtgcccc tcattcctgt ttgggccaag gccgaggacc tgcgagtagg gctcagttgc    900

ctagagcccc ttcagcccat cgcccagttc actttgcttg tgggatctcc ccgttgctcc    960

tgcccctgga ctgagtggca ggccatccta caaacacccg gacactcaac atcagtggtg   1020

tcaagacaac tctaagaagg ttttccgtga tcctgcaaga cctgtgttcc atcctggtga   1080

ttctgtctcc aatttcactg cacaggtacc acagtaagcc agtgctgtgt gctccgaatt   1140

ccagggcatc ccccagctca gccactacac tgagcacaag gactctgtgg ggcccaggag   1200

caggtagtca cccctttggg gtcctcaaca cccggctgtc cccagacttg tgtccaggga   1260

agatagtgtt gagggccctc aaggagagca gggcagggat gcctgagcag gacaaggacc   1320

ccagagtcca agaaaatcct gctgatcaga gaacggtccc cgaggtcacc ggggatgcac   1380

ggtctgcatt ttggcccctg cgggacaatg gaggcctctc tccctttgtg cccaggcccg   1440

ggcctctgca gacagacctc gatgcccaga gctcagaaat cagatataac cagacatccc   1500

agacatcctg gacgagctcg agcacaaaac gaaatgccat ctccagctcc tacagctcca   1560

cgggaggctt gccggggcta aagcagagga ggggaccagc ctcatcccgc tgccagctga   1620

ccctcagtta ctcaaagaca gtgagtgagg acaggcctca ggctgtctct tcgggtcaca   1680

cacggtgtga aaaggcggca gatacagcac cagggcagac actcgcccca aggggtggct   1740

cccccagatc ccaggcctct aggccccgta gacgcaagat tcccctgctg ccaagcaggc   1800

gaggggagcc tttgatgctg ccacctccct tagagctggg gtaccgggtc acggcggaag   1860

acctgcacct ggaaaaacag gcagcattcc agcgcatcaa cagtgcactg cacgttgagg   1920

acaaggccat ctcggactgc agaccctcac ggccttccca cactttgtcc tcacttgcaa   1980

caggggcttc gggtgggcct cccctttcta aagcacccac tatggatgca cagcaggaca   2040

gacccaagtc ccaagactgc ctgggcctag tggcccccct agcatctgct gcagaggtcc   2100

cctctacagc tcccgtgtct gggaagaagc acagaccacc aggacccctg ttctcctcct   2160

cagatcccct tcctgccacc tcttcccact cccgggactc agcccaggtc acctcgctga   2220

ttcctgcccc cttcacagct gcaagcaggg atgccagcat gagaagaaca aggcctggca   2280

cctccgctcc tgcagctgca gcagcagccc ctcccccctc cacattgaac cccacgtcgg   2340

ggtcactact caatgcagtg aatggaggcc cctcacattt cttggcctca gccacagctg   2400

cagcacgtgc ccagaggtca gaagtgagat ataaccagag atcccagacc tcccggacca   2460

gatcctgcct ccaaggaaat gccagctcca gctcccacag ttctacggaa ggcctcccgg   2520

aactaaagcg gaggaggggg ccagcctcat gccactgcca gctggccctc agttcctcaa   2580

acacagtgag tgaggacgga cctcaggctg tctcttcggg tcacacccgc tgtcaaaagg   2640

cagatacagc accagggcag acactcgccc ccaggggtgg ctcccccaga tcccaggcct   2700

ctaggcccca catcaacagt gcactgcacg ttgagggcaa ggccatctcg gactgcagac   2760

cctcacggcc ttcccacact ttgtcctcac ttgcaacggg ggcttcgcgt gggcctcccc   2820

tttctaaagc acccactatg gatgcacagc aggacagacc caagtcccaa gactgcctag   2880

gcctagtggc ccccctagca tctgctgcag aggctcgaga acaacaggat gctttggtcc   2940

tgtatcagca ggacgctttt cgggtagatc ctactgccac cctagctatg ggcacatgtc   3000

agagtcccat gtaa                                                     3014


<210>  4516
<211>  571
<212>  PRT
<213>  Homosapiens

<400>  4516

Met Pro Glu Gln Asp Lys Asp Pro Arg Val Gln Glu Asn Pro Ala Asp 
1               5                   10                  15      


Gln Arg Thr Val Pro Glu Val Thr Gly Asp Ala Arg Ser Ala Phe Trp 
            20                  25                  30          


Pro Leu Arg Asp Asn Gly Gly Leu Ser Pro Phe Val Pro Arg Pro Gly 
        35                  40                  45              


Pro Leu Gln Thr Asp Leu Asp Ala Gln Ser Ser Glu Ile Arg Tyr Asn 
    50                  55                  60                  


Gln Thr Ser Gln Thr Ser Trp Thr Ser Ser Ser Thr Lys Arg Asn Ala 
65                  70                  75                  80  


Ile Ser Ser Ser Tyr Ser Ser Thr Gly Gly Leu Pro Gly Leu Lys Gln 
                85                  90                  95      


Arg Arg Gly Pro Ala Ser Ser Arg Cys Gln Leu Thr Leu Ser Tyr Ser 
            100                 105                 110         


Lys Thr Val Ser Glu Asp Arg Pro Gln Ala Val Ser Ser Gly His Thr 
        115                 120                 125             


Arg Cys Glu Lys Ala Ala Asp Thr Ala Pro Gly Gln Thr Leu Ala Pro 
    130                 135                 140                 


Arg Gly Gly Ser Pro Arg Ser Gln Ala Ser Arg Pro Arg Arg Arg Lys 
145                 150                 155                 160 


Ile Pro Leu Leu Pro Ser Arg Arg Gly Glu Pro Leu Met Leu Pro Pro 
                165                 170                 175     


Pro Leu Glu Leu Gly Tyr Arg Val Thr Ala Glu Asp Leu His Leu Glu 
            180                 185                 190         


Lys Gln Ala Ala Phe Gln Arg Ile Asn Ser Ala Leu His Val Glu Asp 
        195                 200                 205             


Lys Ala Ile Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser 
    210                 215                 220                 


Ser Leu Ala Thr Gly Ala Ser Gly Gly Pro Pro Leu Ser Lys Ala Pro 
225                 230                 235                 240 


Thr Met Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly 
                245                 250                 255     


Leu Val Ala Pro Leu Ala Ser Ala Ala Glu Val Pro Ser Thr Ala Pro 
            260                 265                 270         


Val Ser Gly Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser 
        275                 280                 285             


Asp Pro Leu Pro Ala Thr Ser Ser His Ser Arg Asp Ser Ala Gln Val 
    290                 295                 300                 


Thr Ser Leu Ile Pro Ala Pro Phe Thr Ala Ala Ser Arg Asp Ala Ser 
305                 310                 315                 320 


Met Arg Arg Thr Arg Pro Gly Thr Ser Ala Pro Ala Ala Ala Ala Ala 
                325                 330                 335     


Ala Pro Pro Pro Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn 
            340                 345                 350         


Ala Val Asn Gly Gly Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala 
        355                 360                 365             


Ala Arg Ala Gln Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr 
    370                 375                 380                 


Ser Arg Thr Arg Ser Cys Leu Gln Gly Asn Ala Ser Ser Ser Ser His 
385                 390                 395                 400 


Ser Ser Thr Glu Gly Leu Pro Glu Leu Lys Arg Arg Arg Gly Pro Ala 
                405                 410                 415     


Ser Cys His Cys Gln Leu Ala Leu Ser Ser Ser Asn Thr Val Ser Glu 
            420                 425                 430         


Asp Gly Pro Gln Ala Val Ser Ser Gly His Thr Arg Cys Gln Lys Ala 
        435                 440                 445             


Asp Thr Ala Pro Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg 
    450                 455                 460                 


Ser Gln Ala Ser Arg Pro His Ile Asn Ser Ala Leu His Val Glu Gly 
465                 470                 475                 480 


Lys Ala Ile Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser 
                485                 490                 495     


Ser Leu Ala Thr Gly Ala Ser Arg Gly Pro Pro Leu Ser Lys Ala Pro 
            500                 505                 510         


Thr Met Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly 
        515                 520                 525             


Leu Val Ala Pro Leu Ala Ser Ala Ala Glu Ala Arg Glu Gln Gln Asp 
    530                 535                 540                 


Ala Leu Val Leu Tyr Gln Gln Asp Ala Phe Arg Val Asp Pro Thr Ala 
545                 550                 555                 560 


Thr Leu Ala Met Gly Thr Cys Gln Ser Pro Met 
                565                 570     


<210>  4517
<211>  1568
<212>  DNA
<213>  Homosapiens

<400>  4517
gagggcgtgc aaagagcggc gagccaactt tcacacagcg acgcgagcgg aaaaaccact     60

atgcgacttt tcaactgtgc ggcgggcccg agtcccagtc caggagcccg gctctagcgg    120

atggcgaggg ggtggcgagc gcgcttgggt gcccgccccg cagaggagcg tctggtccac    180

agccggatct cctcggtccc caacccggag ccgcggcccc acgcccgccc cgcctgccga    240

gccttctgca cggcacttga agtgaatgaa tcagccgcgg ccgggtgcgc ggccaccacg    300

tttcctgttt tctttctcaa ctcctcgggc ggcaggcgca gcgcggctcc aacgccgcag    360

ctttccggga acactccccc tcacgcccct ctcggccctc ggcgctgcct ggctcctcct    420

caaccccctt acgaaaagat tccgaattgc aaaagcctgt ccctgtccgt gccacccgcc    480

gcgtccttcc cctcgagctc tgccccgggg gccccgccac ctcgcagtgc catccccccg    540

gcgcagccgg gcgccactcg ctttgaagtg cagacgagga ggcgcgggcg cgagcgtgtg    600

tgtctgtggg gctgctgtgg gactgtctgt gctaggagag cggcggaaaa cccggcgtgg    660

agcgcctgca gtccgccgtc cggggtcgcg cccgccgcgg ggctcaggag ggaccggcac    720

gcaggcgcgc acggccgcgc acctgtctcg ctagaacccc gcgcgccccg ccgagccact    780

gccctccagg ttgcccagac cgctggagcc tctgcgactc cacgaccggc tgcttcctgc    840

gaagtttcac aaacaaggtt atttaggacc ctcaaggttt ctgagggttt aagttttagg    900

gtttctgggg gttcgtttct aaaggcttag gattcaccta cttcaaggag gcagggttgt    960

gggaattaag accgcattct ttttctaccc agcccagtcc ctactaagta ccagacttct   1020

aaatgttggg gcggacagaa acaagcaaac aaaatataca atgttgtggg gtcggaacgc   1080

tttataattc acaaatttga caataggctg cattttcata tgccgaattg cctaagagtt   1140

ctcttaaagg aacagcaatg tgaaagaacc acatggtaag gagaatttac gcatgtcctg   1200

catactactc ctttcccctg tgaattgcat aagacctaga tgatcttggg ccaaggaaga   1260

aaatctggaa gggtgtttct acccaccatg tgcagagtac actacaattt tgagaaaacg   1320

gaaagaccat attcaaaggc atacagaaaa gcctgttctg tttacaaagg ctgacccagg   1380

gcaccaggga cactgtccct aagcagatca gttgtgggag aacttttcta cattagcatg   1440

caataagcaa accattcata gtgaggagaa gtcaaactcc caagggtcca tttgataaaa   1500

ctttgtcatt gtcgagtgga aagaagatac tgagaaactt acactaagtg gtgggatccc   1560

ttgtcttt                                                            1568


<210>  4518
<211>  269
<212>  PRT
<213>  Homosapiens

<400>  4518

Met Ala Arg Gly Trp Arg Ala Arg Leu Gly Ala Arg Pro Ala Glu Glu 
1               5                   10                  15      


Arg Leu Val His Ser Arg Ile Ser Ser Val Pro Asn Pro Glu Pro Arg 
            20                  25                  30          


Pro His Ala Arg Pro Ala Cys Arg Ala Phe Cys Thr Ala Leu Glu Val 
        35                  40                  45              


Asn Glu Ser Ala Ala Ala Gly Cys Ala Ala Thr Thr Phe Pro Val Phe 
    50                  55                  60                  


Phe Leu Asn Ser Ser Gly Gly Arg Arg Ser Ala Ala Pro Thr Pro Gln 
65                  70                  75                  80  


Leu Ser Gly Asn Thr Pro Pro His Ala Pro Leu Gly Pro Arg Arg Cys 
                85                  90                  95      


Leu Ala Pro Pro Gln Pro Pro Tyr Glu Lys Ile Pro Asn Cys Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Val Pro Pro Ala Ala Ser Phe Pro Ser Ser Ser Ala 
        115                 120                 125             


Pro Gly Ala Pro Pro Pro Arg Ser Ala Ile Pro Pro Ala Gln Pro Gly 
    130                 135                 140                 


Ala Thr Arg Phe Glu Val Gln Thr Arg Arg Arg Gly Arg Glu Arg Val 
145                 150                 155                 160 


Cys Leu Trp Gly Cys Cys Gly Thr Val Cys Ala Arg Arg Ala Ala Glu 
                165                 170                 175     


Asn Pro Ala Trp Ser Ala Cys Ser Pro Pro Ser Gly Val Ala Pro Ala 
            180                 185                 190         


Ala Gly Leu Arg Arg Asp Arg His Ala Gly Ala His Gly Arg Ala Pro 
        195                 200                 205             


Val Ser Leu Glu Pro Arg Ala Pro Arg Arg Ala Thr Ala Leu Gln Val 
    210                 215                 220                 


Ala Gln Thr Ala Gly Ala Ser Ala Thr Pro Arg Pro Ala Ala Ser Cys 
225                 230                 235                 240 


Glu Val Ser Gln Thr Arg Leu Phe Arg Thr Leu Lys Val Ser Glu Gly 
                245                 250                 255     


Leu Ser Phe Arg Val Ser Gly Gly Ser Phe Leu Lys Ala 
            260                 265                 


<210>  4519
<211>  1568
<212>  DNA
<213>  Homosapiens

<400>  4519
gagggcgtgc aaagagcggc gagccaactt tcacacagcg acgcgagcgg aaaaaccact     60

atgcgacttt tcaactgtgc ggcgggcccg agtcccagtc caggagcccg gctctagcgg    120

atggcgaggg ggtggcgagc gcgcttgggt gcccgccccg cagaggagcg tctggtccac    180

agccggatct cctcggtccc caacccggag ccgcggcccc acgcccgccc cgcctgccga    240

gccttctgca cggcacttga agtgaatgaa tcagccgcgg ccgggtgcgc ggccaccacg    300

tttcctgttt tctttctcaa ctcctcgggc ggcaggcgca gcgcggctcc aacgccgcag    360

ctttccggga acactccccc tcacgcccct ctcggccctc ggcgctgcct ggctcctcct    420

caaccccctt acgaaaagat tccgaattgc aaaagcctgt ccctgtccgt gccacccgcc    480

gcgtccttcc cctcgagctc tgccccgggg gccccgccac ctcgcagtgc catccccccg    540

gcgcagccgg gcgccactcg ctttgaagtg cagacgagga ggcgcgggcg cgagcgtgtg    600

tgtctgtggg gctgctgtgg gactgtctgt gctaggagag cggcggaaaa cccggcgtgg    660

agcgcctgca gtccgccgtc cggggtcgcg cccgccgcgg ggctcaggag ggaccggcac    720

gcaggcgcgc acggccgcgc acctgtctcg ctagaacccc gcgcgccccg ccgagccact    780

gccctccagg ttgcccagac cgctggagcc tctgcgactc cacgaccggc tgcttcctgc    840

gaagtttcac aaacaaggtt atttaggacc ctcaaggttt ctgagggttt aagttttagg    900

gtttctgggg gttcgtttct aaaggcttag gattcaccta cttcaaggag gcagggttgt    960

gggaattaag accgcattct ttttctaccc agcccagtcc ctactaagta ccagacttct   1020

aaatgttggg gcggacagaa acaagcaaac aaaatataca atgttgtggg gtcggaacgc   1080

tttataattc acaaatttga caataggctg cattttcata tgccgaattg cctaagagtt   1140

ctcttaaagg aacagcaatg tgaaagaacc acatggtaag gagaatttac gcatgtcctg   1200

catactactc ctttcccctg tgaattgcat aagacctaga tgatcttggg ccaaggaaga   1260

aaatctggaa gggtgtttct acccaccatg tgcagagtac actacaattt tgagaaaacg   1320

gaaagaccat attcaaaggc atacagaaaa gcctgttctg tttacaaagg ctgacccagg   1380

gcaccaggga cactgtccct aagcagatca gttgtgggag aacttttcta cattagcatg   1440

caataagcaa accattcata gtgaggagaa gtcaaactcc caagggtcca tttgataaaa   1500

ctttgtcatt gtcgagtgga aagaagatac tgagaaactt acactaagtg gtgggatccc   1560

ttgtcttt                                                            1568


<210>  4520
<211>  269
<212>  PRT
<213>  Homosapiens

<400>  4520

Met Ala Arg Gly Trp Arg Ala Arg Leu Gly Ala Arg Pro Ala Glu Glu 
1               5                   10                  15      


Arg Leu Val His Ser Arg Ile Ser Ser Val Pro Asn Pro Glu Pro Arg 
            20                  25                  30          


Pro His Ala Arg Pro Ala Cys Arg Ala Phe Cys Thr Ala Leu Glu Val 
        35                  40                  45              


Asn Glu Ser Ala Ala Ala Gly Cys Ala Ala Thr Thr Phe Pro Val Phe 
    50                  55                  60                  


Phe Leu Asn Ser Ser Gly Gly Arg Arg Ser Ala Ala Pro Thr Pro Gln 
65                  70                  75                  80  


Leu Ser Gly Asn Thr Pro Pro His Ala Pro Leu Gly Pro Arg Arg Cys 
                85                  90                  95      


Leu Ala Pro Pro Gln Pro Pro Tyr Glu Lys Ile Pro Asn Cys Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Val Pro Pro Ala Ala Ser Phe Pro Ser Ser Ser Ala 
        115                 120                 125             


Pro Gly Ala Pro Pro Pro Arg Ser Ala Ile Pro Pro Ala Gln Pro Gly 
    130                 135                 140                 


Ala Thr Arg Phe Glu Val Gln Thr Arg Arg Arg Gly Arg Glu Arg Val 
145                 150                 155                 160 


Cys Leu Trp Gly Cys Cys Gly Thr Val Cys Ala Arg Arg Ala Ala Glu 
                165                 170                 175     


Asn Pro Ala Trp Ser Ala Cys Ser Pro Pro Ser Gly Val Ala Pro Ala 
            180                 185                 190         


Ala Gly Leu Arg Arg Asp Arg His Ala Gly Ala His Gly Arg Ala Pro 
        195                 200                 205             


Val Ser Leu Glu Pro Arg Ala Pro Arg Arg Ala Thr Ala Leu Gln Val 
    210                 215                 220                 


Ala Gln Thr Ala Gly Ala Ser Ala Thr Pro Arg Pro Ala Ala Ser Cys 
225                 230                 235                 240 


Glu Val Ser Gln Thr Arg Leu Phe Arg Thr Leu Lys Val Ser Glu Gly 
                245                 250                 255     


Leu Ser Phe Arg Val Ser Gly Gly Ser Phe Leu Lys Ala 
            260                 265                 


<210>  4521
<211>  2094
<212>  DNA
<213>  Homosapiens

<400>  4521
tctagcggcg ccggtgagtc cgcgtgtgga agtctgtgag gcgcagaggt ggggcaggcc     60

gtctgactag ctaggcggct gggagcgttt tcgtggcggg gaacggaggt tgaattgccc    120

tgcctgggct catagggaag gaggatgtga aggagcttgt gaaggcagag gaagattatt    180

gaataataaa atacagtttt gaaaaaaatg gatgaagaac ctgaaagaac taagcgatgg    240

gaaggaggct atgaaagaac atgggagatt cttaaagaag atgaatctgg atcacttaaa    300

gctacaatag aagacattct attcaaggca aagagaaaaa gagtatttga gcaccatgga    360

caagttcgac ttggaatgat gcgccacctt tatgtggtag tagatggatc aagaacaatg    420

gaagaccaag atttaaagcc taatagactg acgtgtactt taaagttgtt ggaatacttt    480

gtagaggaat attttgatca aaatcctatt agtcagattg gaataattgt aactaagagt    540

aaaagagctg aaaaattgac tgaactttca ggaaacccaa gaaaacatat aacgtctttg    600

aaggaagctg tggatatgac ctgccatgga gagccatctc tttataattc cctaagcatg    660

gctatgcaga ctctaaaaca catgcctgga catacaagtc gagaagtact aatcatcttt    720

agcagcctta caacttgcga tccatctaat atttatgatc taatcaagac cctaaaggca    780

gctaaaatta gagtatctgt tattggattg tctgcagaag ttcgcgtttg cactgtactt    840

gctcgtgaaa ctggtggcac gtaccatgtt attttagatg aaagccatta caaagagttg    900

ctcacacatc atcttagtcc tcctcctgct agctcaagtt ctgaatgctc acttattcgt    960

atgggatttc ctcagcacac cattgcttct ttatctgacc aggatgcaaa accctctttc   1020

agcatggcgc atttggatgg caatactgag ccagggctta cattaggagg ctatttctgc   1080

ccacagtgtc gggcaaagta ctgtgagcta cctgttgaat gtaaaatctg tggtcttact   1140

ttggtgtctg ctccccactt ggcacggtct taccatcatt tgtttccttt ggatgctttt   1200

caagaaattc ccctagaaga atataatgga gaaagatttt gttatggatg tcagggggaa   1260

ttgaaagacc aacatgttta tgtttgtgct gtgtgccaaa atgttttctg tgtggactgt   1320

gatgtttttg ttcatgattc tctacactgt tgccctggct gtattcataa gattccagct   1380

ccttcaggtg tttgattcca gcatgtagta tacattgtat gtgttaaaaa gaaatttgca   1440

actgtgaata aaaggacttc tttagaagaa gcttcattta aaacatgaaa ggataatctg   1500

acttaagaaa ctttttgcta agaaaaggta atattttatt aaattttaaa tttgtgttgt   1560

cacagaaata cctgaaattc agtagtactt cattcaatta attttgtttt ctattatttt   1620

gagttatact gttttcaaag tcattatgca gtatgtataa acttataaga attaaattga   1680

tgtgataatt ttatgttttt ataattaaat atagaatctt tatgatttat gttaattcat   1740

taatttagtg taagaagaaa gttaagtctg aatgtaaatt cagtgtaaga tgaaaattta   1800

tcaatactta tgaaattagg ctgggcgctg tggctcacac ctgtaatccc aacactttgg   1860

gaggctgagg tgggcagatc acttgaggtc aggagttcga gaccagcctg gccaacatgg   1920

tgaaaccccg tcactactaa aaatacaaaa aataattagc cgggcatggt ggttcacgcc   1980

tggagtccca gctacttggg aggctgaggc aggagaatcg cttgaaccca ggaggcggag   2040

gttgcagtga gccgagattg tgccactgca ctccacccta gagtaagact ccct         2094


<210>  4522
<211>  395
<212>  PRT
<213>  Homosapiens

<400>  4522

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Ile Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Leu Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
            340                 345                 350         


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
        355                 360                 365             


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
    370                 375                 380                 


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
385                 390                 395 


<210>  4523
<211>  2339
<212>  DNA
<213>  Homosapiens

<400>  4523
ttctagcggc gccgattatt gaataataaa atacagtttt gaaaaaaatg gatgaagaac     60

ctgaaagaac taagcgatgg gaaggaggct atgaaagaac atgggagatt cttaaagaag    120

atgaatctgg atcacttaaa gctacaatag aagacattct attcaaggca aagagaaaaa    180

gatgcgccac ctttatgtgg tagtagatgg atcaagaaca atggaagacc aagatttaaa    240

gcctaataga ctgacgtgta ctttaaagtt gttggaatac tttgtagagg aatattttga    300

tcaaaatcct attagtcaga ttggaataat tgtaactaag agtaaaagag ctgaaaaatt    360

gactgaactt tcagatggag tcttgctctg tcgccaggct agagtgcagt ggcacaattt    420

cggatcactg caaagtccgc ctcacgggtt caagcgattc cctgcctcag cctcctgagt    480

agctggaact acagatgccc gccaccacgc cctgctaatt ttttgtattt tagtagatac    540

ggggtttcac catgttggcc agtatggtct caatctcttg accttgtgat cagcccgcct    600

cagcctctca aagtgctggg attacaggct tgagccaccg catccggcct tatcctgaag    660

atattaaaat acagttattg taatcattta taaaatccag ttaatcttaa aattaaattc    720

ttaaaaagtt aagcatctaa tttaaaaggg aaaaagtata aaaattaaac tgtagctatt    780

gctaatgaat caatttttct gcttccatga catacctaac tgaattttag tttcaaaacg    840

tagtaatggc attttttatt tgctttgata tatatgctgt tacaaatttg catcactgat    900

tctattttat tttctgtgaa atacactctc ccttaaatct ggttttcaac cttttatcct    960

tgccggcaca cataagggaa atgacatact ttcttcatta gtagtttttc attaaatgca   1020

gtgaggagtg aaatgtacat tggcctggag tgattcaaga aactcagttg tgagtaacca   1080

aaagaatgtc acactagctt aagtgcagaa ggaaaatttt gggctatgtt caaaggtggg   1140

ccaattccat atatagttgc tgcatatgtt ggggtcctgg ctttgtctgg cttcattctc   1200

tgatagattt tctggaagtt gaaaagatgt ctcttaattg tcccagttct acattgtacc   1260

cgtagcctat agcttcagca cacgtctagg gagaactctg attggcctga gttacgatct   1320

gcccatccat gaacaaagtg gccaggaaat gaagtatttt gtttgtacgc ttcgattgcc   1380

tgctgatgcc cagagcagga tagaagtagg gtcagcacca catgaactaa gcaggattat   1440

tatatagtgg aagaaggatg gttcctccaa ggtaggaata taaggtcaat attttcctct   1500

cactttaccc accccgagtt accagcagtt ttctattgct tctttttttt ttttttgaga   1560

aggagtctct cactctgtcg cccaggcggt gctgtcttgg ctcactgcaa cctccgcctc   1620

ccgggttcaa gagattctcc tgcctccccc tcccgagtag ctgggattac aggtgtgcgc   1680

tgccacacct ggctaatttt atttttagta gagacaggat ttcaccatgc tggccaggct   1740

gatctcgaac tcctgacctc aggtgatcta cccacctcag cctcccaaag tgttgggatt   1800

acaggcatca gccaccatgc ccggccccag cagttttcta tggatgttag tgaagtcatg   1860

tataaagatg aaaaatattc tggagattct gacaggcctc ttgaagccac ctttttttcc   1920

ctccaatcag accactgctg taaaccacac tgacactatt gtagtatgct tttttcctat   1980

acccataaca cagtgggaga ttaaaaataa ttttgtaggg taggaagaga agtggataga   2040

gagccaggag atctaggttt gggtgctgct ggtcctgcag ttaagcaggc atatgtcttt   2100

gggcaagtca tttcacttgt ttagattaat tttctcactt atgaagtgag ggatttggac   2160

tgcttagcga ggtacttttc atctctaaaa tttatgaatc taaaatactt gcagtaaata   2220

ttaaatatta caaatggtta atattttaaa acttactcag atgagtaaaa actcaaggga   2280

gctccaagtt gatgaataga caaagaagac atgattcaca cagaaaaaac ccagaaatt    2339


<210>  4524
<211>  98
<212>  PRT
<213>  Homosapiens

<400>  4524

Met Arg His Leu Tyr Val Val Val Asp Gly Ser Arg Thr Met Glu Asp 
1               5                   10                  15      


Gln Asp Leu Lys Pro Asn Arg Leu Thr Cys Thr Leu Lys Leu Leu Glu 
            20                  25                  30          


Tyr Phe Val Glu Glu Tyr Phe Asp Gln Asn Pro Ile Ser Gln Ile Gly 
        35                  40                  45              


Ile Ile Val Thr Lys Ser Lys Arg Ala Glu Lys Leu Thr Glu Leu Ser 
    50                  55                  60                  


Asp Gly Val Leu Leu Cys Arg Gln Ala Arg Val Gln Trp His Asn Phe 
65                  70                  75                  80  


Gly Ser Leu Gln Ser Pro Pro His Gly Phe Lys Arg Phe Pro Ala Ser 
                85                  90                  95      


Ala Ser 
        


<210>  4525
<211>  2056
<212>  DNA
<213>  Homosapiens

<400>  4525
tgacttccgg ggcgccccta aagcggcgga gaggagtgtc gggctgagtt tccggctgag     60

agtccttcta gcggcgccga ttattgaata ataaaataca gttttgaaaa aaatggatga    120

agaacctgaa agaactaagc gatgggaagg aggctatgaa agaacatggg agattcttaa    180

agaagatgaa tctggatcac ttaaagctac aatagaagac attctattca aggcaaagag    240

aaaaagagta tttgagcacc atggacaagt tcgacttgga atgatgcgcc acctttatgt    300

ggtagtagat ggatcaagaa caatggaaga ccaagattta aagcctaata gactgacgtg    360

tactttaaag ttgttggaat actttgtaga ggaatatttt gatcaaaatc ctattagtca    420

gattggaata attgtaacta agagtaaaag agctgaaaaa ttgactgaac tttcaggaaa    480

cccaagaaaa catataacgt ctttgaagga agctgtggat atgacctgcc atggagagcc    540

atctctttat aattccctaa gcatggctat gcagactcta aatatctcca agacacatgc    600

ctggacatac aagtcgagaa gtactaatca tctttagcag ccttacaact tgcgatccat    660

ctaatattta tgatctaatc aagaccctaa aggcagctaa aattagagta tctgttattg    720

gattgtctgc agaagttcgc gtttgcactg tacttgctcg tgaaactggt ggtatatata    780

taatttattt aatatttgct tataattact gtgtaggaaa taatttatta attaaattag    840

gatgttttaa tctgttctga gctactaaac ttaaagtagt ctaaaatatg ggcagtcatc    900

ttaaatatat cattgattcc ataagaaatc atctccaaat gcaaagagtt ttcagtactt    960

atgtcagtat ttagaggagg tattataact cttggaaagc tggaaatttt actgtatgta   1020

attctttata aagattttat aacttgtctt taattaaatt gtaattacag gccaggcatg   1080

atagctcatg cctgtaatct caacattttg gtaggccaag gcaggagaat cacttgaggc   1140

cagaagtttg agatcagtct ggttaacata gtgagacctg tctctattta tatgttaaaa   1200

taataataat agtaataata atcaattgta attatagtta ttcctagaga agttgattta   1260

gatatattac ttaaataagg ttttaaaagt gataatttag ctaaaatcat tattttaaaa   1320

atgtacattt tcagatgata caacttttac agaattacat agaacgtaca gttcgttatg   1380

tctatgaagg tgtttttttt tcccttttca tcttgttagg cacgtaccat gttattttag   1440

atgaaagcca ttacaaagag ttgctcacac atcatcttag tcctcctcct gctagctcaa   1500

gttctgaatg ctcacttatt cgtatgggta agtgttttta tgtttttaaa aaatacatat   1560

ctaggctctc tattttcatt tgcacaagtt attttaatat ttaagaattt ttaaagaaaa   1620

aatatgcttg ttgaagcaat tttggaaagt acagagaagt ggaaaaaaaa aattaaaact   1680

accagtagtc ctgtcaccca gaaaatactg ttggctttct ttatttttaa ggctagaaag   1740

gtataaactg tgtttataga aaaatactta tattaagccg ggctcggtgg ctcacacctg   1800

taatcccagc actttgggag gccgaggtgg gcggatcttg aggtcaggag atcgagacca   1860

tcctggctaa cacggtgaaa ccccatctct actaaaaata caaaaaatta gccaggcgtg   1920

gtggcgggcg cctgtaatcc cagctcctcg ggaggctgag gcaggagaat ggcatgaacc   1980

cgggaggcag agctggcaat gagccgagat cacaccactg cactctagcc tgggcgacag   2040

agcgagactc tgtctc                                                   2056


<210>  4526
<211>  174
<212>  PRT
<213>  Homosapiens

<400>  4526

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Asn Ile Ser Lys 
145                 150                 155                 160 


Thr His Ala Trp Thr Tyr Lys Ser Arg Ser Thr Asn His Leu 
                165                 170                 


<210>  4527
<211>  558
<212>  DNA
<213>  Homosapiens

<400>  4527
tctagcggcg ccggctggag tgcagtggca caaccttggc tcgctccagt gtctacctcc     60

caggttcaag tgattctcct gcctcagcct cccgagtagc tgggattaca gattattgaa    120

taataaaata cagttttgaa aaaaatggat gaagaacctg aaagaactaa gcgatgggaa    180

ggaggctatg aaagaacatg ggagattctt aaagaagatg aatctggatc acttaaagct    240

acaatagaag acattctatt caaggcaaag agaaaaagag tatttgagca ccatggacaa    300

gttcgacttg gaatgatgcg ccacctttat gtggtagtag atggatcaag aacaatggaa    360

gaccaagatt taaagcctaa tagactgacg tgtactttaa aggtaaaatt taagtttata    420

ctaaatcatt taaatttgta ccaaaatcac ttaaactttt actaaaaaag tggggaagaa    480

cactggattc taaaggatat ttttaaagaa tgcaatattt tttatttttt gccttgtatt    540

tttagttaat gctaatga                                                  558


<210>  4528
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  4528

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Val Lys Phe Lys Phe Ile Leu Asn His Leu 
                85                  90                  95      


Asn Leu Tyr Gln Asn His Leu Asn Phe Tyr 
            100                 105     


<210>  4529
<211>  1128
<212>  DNA
<213>  Homosapiens

<400>  4529
tctagcggcg ccggtgagtc cgcgtgtgga agtctgtgag gcgcagaggt ggggcaggcc     60

gtctgactag ctaggcggct gggagcgttt tcgtggcggg gaacggaggt tgaattgccc    120

tgcctgggct catagggaag gaggatgtga aggagcttgt gaaggcagag gaagattatt    180

gaataataaa atacagtttt gaaaaaaatg gatgaagaac ctgaaagaac taagcgatgg    240

gaaggaggct atgaaagaac atgggagatt cttaaagaag atgaatctgg atcacttaaa    300

gctacaatag aagacattct attcaaggca aagagaaaaa gagtatttga gcaccatgga    360

caagttcgac ttggaatgat gcgccacctt tatgtggtag tagatggatc aagaacaatg    420

gaagaccaag atttaaagcc taatagactg acgtgtactt taaagttgtt ggaatacttt    480

gtagaggaat attttgatca aaatcctatt agtcagattg gaataattgt aactaagagt    540

aaaagagctg aaaaattgac tgaactttca ggaaacccaa gaaaacatat aacgtctttg    600

aaggaagctg tggatatgac ctgccatgga gagccatctc tttataattc cctaagcatg    660

gctatgcaga ctctaaagtt agtattatac attatgtata attgaattag aagtttttta    720

aatgagttaa gttgaagtga tgtgttaata tggggcccat aaacccagct ataacaaaat    780

tgttaagtac gagaattatg tagtgttatt tatgatgttt agtgtggtgt tggttagtaa    840

tttttatttt acattttagt aagatattgt taaaggtttt ataaaaatat aatttaaaac    900

tgtcggcagt atcaatagta caaaaatagg ttgatgaaaa aatattttat taaaatgaga    960

tttaatatag tataataatt gtaagttggt tgtaccttta ttaacattta ttattttatt   1020

ttgaaagtaa tggccaaaac cacaattcct tttgcaccaa tgtcatatat ctgtaaatta   1080

atagatatgg caagttcagc tatatggaat agagctaaga ccccaaag                1128


<210>  4530
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  4530

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys Leu Val Leu 
145                 150                 155                 160 


Tyr Ile Met Tyr Asn 
                165 


<210>  4531
<211>  806
<212>  DNA
<213>  Homosapiens

<400>  4531
cggctgagag tccttctagc ggcgccgatt attgaataat aaaatacagt tttgaaaaaa     60

atggatgaag aacctgaaag aactaagcga tgggaaggag gctatgaaag aacatgggag    120

attcttaaag aagatgaatc tggatcactt aaagctacaa tagaagacat tctattcaag    180

gcaaagagaa aaagagtatt tgagcaccat ggacaagttc gacttggaat gatgcgccac    240

ctttatgtgg tagtagatgg atcaagaaca atggaagacc aagatttaaa gcctaataga    300

ctgacgtgta ctttaaagga aacccaagaa aacatataac gtctttgaag gaagctgtgg    360

atatgacctg ccatggagag ccatctcttt ataattccct aagcatggct atgcagactc    420

taaaacacat gcctggacat acaagtcgag aagtactaat catctttagc agccttacaa    480

cttgcgatcc atctaatatt tatgatctaa tcaagaccct aaaggcagct aaaattagag    540

tatctgttat tggattgtct gcagaagttc gcgtttgcac tgtacttgct cgtgaaactg    600

gtggcacgta ccatgttatt ttagatgaaa gccattacaa agagttgctc acacatcatc    660

ttagtcctcc tcctgctagc tcaagttctg aatgctcact tattcgtatg ggatttcctc    720

agcacaccat tgcttcttta tctgaccagg atgcaaaacc ctctttcagc atggcgcatt    780

tggatggcaa tactgagcca gggctt                                         806


<210>  4532
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  4532

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Glu Thr Gln Glu Asn Ile 
                85                  90          


<210>  4533
<211>  799
<212>  DNA
<213>  Homosapiens

<400>  4533
ccttctagcg gcgccggtga gtccgcgtgt ggaagtctgt gaggcgcaga ggtggggcag     60

gccgtctgac tagctaggcg gctgggagcg ttttcgtggc ggggaacgga ggttgaattg    120

ccctgcctgg gctcataggg aaggaggatg tgaaggagct tgtgaaggca gaggaagatt    180

attgaataat aaaatacagt tttgaaaaaa atggatgaag aacctgaaag aactaagcga    240

tgggaaggag gctatgaaag aacatgggag attcttaaag aagatgaatc tggatcactt    300

aaagctacaa tagaagacat tctattcaag gcaaagagaa aaagagtatt tgagcaccat    360

ggacaagttc gacttggaat gatgcgccac ctttatgtgg tagtagatgg atcaagaaca    420

atggaagacc aagatttaaa gcctaataga ctgacgtgta ctttaaaggt aaaatttaag    480

tttatactaa atcatttaaa tttgtaccaa aatcacttaa acttttacta aaaaagtggg    540

gaagaacact ggattctaaa ggatattttt aaagaatgca atatttttta ttttttgcct    600

tgtattttta gttaatgcta atgatagcta agtagaagta ctgccaggtt atttagggaa    660

attttaaacc aacatagcta attatttgtg tttttaattt ctatcctccc accccacatc    720

aggatcttgg tttatcagtt atcccttttc tttcttgaat cttcattctc ctttgcctta    780

cttaactctg tctcctcag                                                 799


<210>  4534
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  4534

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Val Lys Phe Lys Phe Ile Leu Asn His Leu 
                85                  90                  95      


Asn Leu Tyr Gln Asn His Leu Asn Phe Tyr 
            100                 105     


<210>  4535
<211>  621
<212>  DNA
<213>  Homosapiens

<400>  4535
tctagcggcg ccggtgagtc cgcgtgtgga agtctgtgag gcgcagaggt ggggcaggcc     60

gtctgactag ctaggcggct gggagcgttt tcgtggcggg gaacggaggt tgaattgccc    120

tgcctgggct catagggaag gaggatgtga aggagcttgt gaaggcagag gaagattatt    180

gaataataaa atacagtttt gaaaaaaatg gatgaagaac ctgaaagaac taagcgatgg    240

gaaggaggct atgaaagaac atgggagatt cttaaagaag atgaatctgg atcacttaaa    300

gctacaatag aagacattct attcaaggca aagagaaaaa gagtatttga gcaccatgga    360

caagttcgac ttggaatgat gcgccacctt tatgtggtag tagatggatc aagaacaatg    420

gaagaccaag atttaaagcc taatagactg acgtgtactt taaagttgtt ggaatacttt    480

gtagaggaat attttgatca aaatcctatt agtcagattg gaataattgt aactaagagt    540

aaaagagctg aaaaattgac tgaactttca ggtgtttgat tccagcatgt agtatacatt    600

gtatgtgtta aaaagaaatt t                                              621


<210>  4536
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  4536

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Val 
        115                 120             


<210>  4537
<211>  1080
<212>  DNA
<213>  Homosapiens

<400>  4537
ccggctgaga gtccttctag cggcgccggc tggagtgcag tggcacaacc ttggctcgct     60

ccagtgtcta cctcccaggt tcaagtgatt ctcctgcctc agcctcccga gtagctggga    120

ttacagatta ttgaataata aaatacagtt ttgaaaaaaa tggatgaaga acctgaaaga    180

actaagcgat gggaaggagg ctatgaaaga acatgggaga ttcttaaaga agatgaatct    240

ggatcactta aagctacaat agaagacatt ctattcaagg caaagagaaa aagagtattt    300

gagcaccatg gacaagttcg acttggaatg atgcgccacc tttatgtggt agtagatgga    360

tcaagaacaa tggaagacca agatttaaag cctaatagac tgacgtgtac tttaaagttg    420

ttggaatact ttgtagagga atattttgat caaaatccta ttagtcagat tggaataatt    480

gtaactaaga gtaaaagagc tgaaaaattg actgaacttt caggaaaccc aagaaaacat    540

ataacgtctt tgaaggaagc tgtggatatg acctgccatg gagagccatc tctttataat    600

tccctaagca tggctatgca gactctaaag ttagtattat acattatgta taattgaatt    660

agaagttttt taaatgagtt aagttgaagt gatgtgttaa tatggggccc ataaacccag    720

ctataacaaa attgttaagt acgagaatta tgtagtgtta tttatgatgt ttagtgtggt    780

gttggttagt aatttttatt ttacatttta gtaagatatt gttaaaggtt ttataaaaat    840

ataatttaaa actgtcggca gtatcaatag tacaaaaata ggttgatgaa aaaatatttt    900

attaaaatga gatttaatat agtataataa ttgtaagttg gttgtacctt tattaacatt    960

tattatttta ttttgaaagt aatggccaaa accacaattc cttttgcacc aatgtcatat   1020

atctgtaaat taatagatat ggcaagttca gctatatgga atagagctaa gaccccaaag   1080


<210>  4538
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  4538

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys Leu Val Leu 
145                 150                 155                 160 


Tyr Ile Met Tyr Asn 
                165 


<210>  4539
<211>  1393
<212>  DNA
<213>  Homosapiens

<400>  4539
tctagcggcg ccggtgagtc cgcgtgtgga agtctgtgag gcgcagaggt ggggcaggcc     60

gtctgactag ctaggcggct gggagcgttt tcgtggcggg gaacggaggt tgaattgccc    120

tgcctgggct catagggaag gaggatgtga aggagcttgt gaaggcagag gaagattatt    180

gaataataaa atacagtttt gaaaaaaatg gatgaagaac ctgaaagaac taagcgatgg    240

gaaggaggct atgaaagaac atgggagatt cttaaagaag atgaatctgg atcacttaaa    300

gctacaatag aagacattct attcaaggca aagagaaaaa gagtatttga gcaccatgga    360

caagttcgac ttggaatgat gcgccacctt tatgtggtag tagatggatc aagaacaatg    420

gaagaccaag atttaaagcc taatagactg acgtgtactt taaagttgtt ggaatacttt    480

gtagaggaat attttgatca aaatcctatt agtcagattg gaataattgt aactaagagt    540

aaaagagctg aaaaattgac tgaactttca ggaaacccaa gaaaacatat aacgtctttg    600

aaggaagctg tggatatgac ctgccatgga gagccatctc tttataattc cctaagcatg    660

gctatgcaga ctctaaaaca catgcctgga catacaagtc gagaagtact aatcatcttt    720

agcagcctta caacttgcga tccatctaat atttatgatc taatcaaggt agaccaaaaa    780

atcaaaacca aagttataac tgtaaagaga attctgtagc aaattgattt atatatatat    840

gtatttttgt atgtgtgatt catctttgtg ttagatgtat tgaatttatt actagttttc    900

agagcattct ttatttttca aatacattaa atcttaaatg tttttcttct ttcctaaaac    960

tatctatcta cttggatttt atgaagaccc taaaggcagc taaaattaga gtatctgtta   1020

ttggattgtc tgcagaagtt cgcgtttgca ctgtacttgc tcgtgaaact ggtggtatat   1080

atataattta tttaatattt gcttataatt actgtgtagg aaataattta ttaattaaat   1140

taggatgttt taatctgttc tgagctacta aacttaaagt agtctaaaat atgggcagtc   1200

atcttaaata tatcattgat tccataagaa atcatctcca aatgcaaaga gttttcagta   1260

cttatgtcag tatttagagg aggtattata actcttggaa agctggaaat tttactgtat   1320

gtaattcttt ataaagattt tataacttgt ctttaattaa attgtaatta caggccaggc   1380

atgatagctc atg                                                      1393


<210>  4540
<211>  203
<212>  PRT
<213>  Homosapiens

<400>  4540

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Val Asp Gln Lys Ile 
            180                 185                 190         


Lys Thr Lys Val Ile Thr Val Lys Arg Ile Leu 
        195                 200             


<210>  4541
<211>  1033
<212>  DNA
<213>  Homosapiens

<400>  4541
tgacttccgg ggcgccccta aagcggcgga gaggagtgtc gggctgagtt tccggctgag     60

agtccttcta gcggcgccga ttattgaata ataaaataca gttttgaaaa aaatggatga    120

agaacctgaa agaactaagc gatgggaagg aggctatgaa agaacatggg agattcttaa    180

agaagatgaa tctggatcac ttaaagctac aatagaagac attctattca aggcaaagag    240

aaaaagagta tttgagcacc atggacaagt tcgacttgga atgatgcgcc acctttatgt    300

ggtagtagat ggatcaagaa caatggaaga ccaagattta aagcctaata gactgacgtg    360

tactttaaag ttgttggaat actttgtaga ggaatatttt gatcaaaatc ctattagtca    420

gattggaata attgtaacta agagtaaaag agctgaaaaa ttgactgaac tttcaggaaa    480

cccaagaaaa catataacgt ctttgaagga agctgtggat atgacctgcc atggagagcc    540

atctctttat aattccctaa gcatggctat gcagactcta aagttagtat tatacattat    600

gtataattga attagaagtt ttttaaatga gttaagttga agtgatgtgt taatatgggg    660

cccataaacc cagctataac aaaattgtta agtacgagaa ttatgtagtg ttatttatga    720

tgtttagtgt ggtgttggtt agtaattttt attttacatt ttagtaagat attgttaaag    780

gttttataaa aatataattt aaaactgtcg gcagtatcaa tagtacaaaa ataggttgat    840

gaaaaaatat tttattaaaa tgagatttaa tatagtataa taattgtaag ttggttgtac    900

ctttattaac atttattatt ttattttgaa agtaatggcc aaaaccacaa ttccttttgc    960

accaatgtca tatatctgta aattaataga tatggcaagt tcagctatat ggaatagagc   1020

taagacccca aag                                                      1033


<210>  4542
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  4542

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys Leu Val Leu 
145                 150                 155                 160 


Tyr Ile Met Tyr Asn 
                165 


<210>  4543
<211>  1830
<212>  DNA
<213>  Homosapiens

<400>  4543
tctagcggcg ccggtgagtc cgcgtgtgga agtctgtgag gcgcagaggt ggggcaggcc     60

gtctgactag ctaggcggct gggagcgttt tcgtggcggg gaacggaggt tgaattgccc    120

tgcctgggct catagggaag gaggatgtga aggagcttgt gaaggcagag gaagattatt    180

gaataataaa atacagtttt gaaaaaaatg gatgaagaac ctgaaagaac taagcgatgg    240

gaaggaggct atgaaagaac atgggagatt cttaaagaag atgaatctgg atcacttaaa    300

gctacaatag aagacattct attcaaggca aagagaaaaa gagtatttga gcaccatgga    360

caagttcgac ttggaatgat gcgccacctt tatgtggtag tagatggatc aagaacaatg    420

gaagaccaag atttaaagcc taatagactg acgtgtactt taaagttgtt ggaatacttt    480

gtagaggaat attttgatca aaatcctatt agtcagattg gaataattgt aactaagagt    540

aaaagagctg aaaaattgac tgaactttca ggaaacccaa gaaaacatat aacgtctttg    600

aaggaagctg tggatatgac ctgccatgga gagccatctc tttataattc cctaagcatg    660

gctatgcaga ctctaaaaca catgcctgga catacaagtc gagaagtact aatcatcttt    720

agcagcctta caacttgcga tccatctaat atttatgatc taatcaagac cctaaaggca    780

gctaaaatta gagtatctgt tattggattg tctgcagaag ttcgcgtttg cactgtactt    840

gctcgtgaaa ctggtggcac gtaccatgtt attttagatg aaagccatta caaagagttg    900

ctcacacatc atcttagtcc tcctcctgct agctcaagtt ctgaatgctc acttattcgt    960

atgggatttc ctcagcacac cattgcttct ttatctgacc aggatgcaaa accctctttc   1020

agcatggcgc atttggatgg caatactgag ccagggctta cattaggagg ctatttctgc   1080

ccacagtgtc gggcaaagta ctgtgagcta cctgttgaat gtaaaatctg tggtcttact   1140

ttggtgtctg ctccccactt ggcacggtct taccatcatt tgtttccttt ggatgctttt   1200

caagaaattc ccctagaaga atataatgga gaaaggtatt tcagtttgga ctaatttata   1260

tctgttataa gtggtaagct aatgtttgaa tagattgtta ctaccttaaa aaataatctg   1320

attaacttgg acaagagtac ttctaatatg gaagatgaga taaagaatgc catagttatg   1380

attgaaatga ctcgttgcta aatagatctg aatctccaga aaccaaataa tttcactaaa   1440

cccacctatg tataaatagg ggtgatgatt gtactactaa atcagttttc cagaaggaaa   1500

agaaaaaaag ccctgattgg tagtatttgc tgatttccat ggtttgaata ctcccaccat   1560

ggccaatttt tagctacaat taacaaccag ctttcttgaa tacatattta acaatatatc   1620

cttttgatcc agtacaatcc agtcctagca cactactgaa aataagaggc tcattcagca   1680

ctttgggagg ctgaggtggg aggatcactt gaggccagga gttgaagact agctggggca   1740

acatagtgag acactgtctc ttaaaaaaga aaaaaaaagc tggacatggt ggctcatacc   1800

tgtaatccca gcacttttgg aggccaaggc                                    1830


<210>  4544
<211>  348
<212>  PRT
<213>  Homosapiens

<400>  4544

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Ile Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Leu Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Tyr Phe Ser Leu Asp 
            340                 345             


<210>  4545
<211>  1510
<212>  DNA
<213>  Homosapiens

<400>  4545
tctagcggcg ccggtgagtc cgcgtgtgga agtctgtgag gcgcagaggt ggggcaggcc     60

gtctgactag ctaggcggct gggagcgttt tcgtggcggg gaacggaggt tgaattgccc    120

tgcctgggct catagggaag gaggatgtga aggagcttgt gaaggcagag gaagattatt    180

gaataataaa atacagtttt gaaaaaaatg gatgaagaac ctgaaagaac taagcgatgg    240

gaaggaggct atgaaagaac atgggagatt cttaaagaag atgaatctgg atcacttaaa    300

gctacaatag aagacattct attcaaggca aagagaaaaa gagtatttga gcaccatgga    360

caagttcgac ttggaatgat gcgccacctt tatgtggtag tagatggatc aagaacaatg    420

gaagaccaag atttaaagcc taatagactg acgtgtactt taaagttgtt ggaatacttt    480

gtagaggaat attttgatca aaatcctatt agtcagattg gaataattgt aactaagagt    540

aaaagagctg aaaaattgac tgaactttca ggaaacccaa gaaaacatat aacgtctttt    600

tcctttggat gcttttcaag aaattcccct agaagaatat aatggagaaa gattttgtta    660

tggatgtcag ggggaattga aagaccaaca tgtttatgtt tgtgctgtgt gccaaaatgt    720

tttctgtgtg gactgtgatg tttttgttca tgattctcta cactgttgcc ctggctgtat    780

tcataagatt ccagctcctt caggtgtttg attccagcat gtagtataca ttgtatgtgt    840

taaaaagaaa tttgcaactg tgaataaaag gacttcttta gaagaagctt catttaaaac    900

atgaaaggat aatctgactt aagaaacttt ttgctaagaa aaggtaatat tttattaaat    960

tttaaatttg tgttgtcaca gaaatacctg aaattcagta gtacttcatt caattaattt   1020

tgttttctat tattttgagt tatactgttt tcaaagtcat tatgcagtat gtataaactt   1080

ataagaatta aattgatgtg ataattttat gtttttataa ttaaatatag aatctttatg   1140

atttatgtta attcattaat ttagtgtaag aagaaagtta agtctgaatg taaattcagt   1200

gtaagatgaa aatttatcaa tacttatgaa attaggctgg gcgctgtggc tcacacctgt   1260

aatcccaaca ctttgggagg ctgaggtggg cagatcactt gaggtcagga gttcgagacc   1320

agcctggcca acatggtgaa accccgtcac tactaaaaat acaaaaaata attagccggg   1380

catggtggtt cacgcctgga gtcccagcta cttgggaggc tgaggcagga gaatcgcttg   1440

aacccaggag gcggaggttg cagtgagccg agattgtgcc actgcactcc accctagagt   1500

aagactccct                                                          1510


<210>  4546
<211>  144
<212>  PRT
<213>  Homosapiens

<400>  4546

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Phe Ser Phe Gly Cys Phe Ser Arg Asn Ser Pro Arg Arg Ile 
    130                 135                 140                 


<210>  4547
<211>  2118
<212>  DNA
<213>  Homosapiens

<400>  4547
tctagcggcg ccggtgagtc cgcgtgtgga agtctgtgag gcgcagaggt ggggcaggcc     60

gtctgactag ctaggcggct gggagcgttt tcgtggcggg gaacggaggt tgaattgccc    120

tgcctgggct catagggaag gaggatgtga aggagcttgt gaaggcagag gaagattatt    180

gaataataaa atacagtttt gaaaaaaatg gatgaagaac ctgaaagaac taagcgatgg    240

gaaggaggct atgaaagaac atgggagatt cttaaagaag atgaatctgg atcacttaaa    300

gctacaatag aagacattct attcaaggca aagagaaaaa gagtatttga gcaccatgga    360

caagttcgac ttggaatgat gcgccacctt tatgtggtag tagatggatc aagaacaatg    420

gaagaccaag atttaaagcc taatagactg acgtgtactt taaagttgtt ggaatacttt    480

gtagaggaat attttgatca aaatcctatt agtcagattg gaataattgt aactaagagt    540

aaaagagctg aaaaattgac tgaactttca ggaaacccaa gaaaacatat aacgtctttg    600

aaggaagctg tggatatgac ctgccatgga gagccatctc tttataattc cctaagcatg    660

gctatgcaga ctctaaaaca catgcctgga catacaagtc gagaagtact aatcatcttt    720

agcagcctta caacttgcga tccatctaat atttatgatc taatcaagac cctaaaggca    780

gctaaaatta gagtatctgt tattggattg tctgcagaag ttcgcgtttg cactgtactt    840

gctcgtgaaa ctggtggcac gtaccatgtt attttagatg aaagccatta caaagagttg    900

ctcacacatc atcttagtcc tcctcctgct agctcaagtt ctgaatgctc acttattcgt    960

atgggatttc ctcagcacac cattgcttct ttatctgacc aggatgcaaa accctctttc   1020

agcatggcgc atttggatgg caatactgag ccagggctta cattaggagg ctatttctgc   1080

ccacagtgtc gggcaaagta ctgtgagcta cctgttgaat gtaaaatctg tggtcttact   1140

ttggtgtctg ctccccactt ggcacggtct taccatcatt tgtttccttt ggatgctttt   1200

caagaaattc ccctagaaga atataatgga gaaaggctga agaacggcct aggatgatga   1260

ttttgttatg gatgtcaggg ggaattgaaa gaccaacatg tttatgtttg tgctgtgtgc   1320

caaaatgttt tctgtgtgga ctgtgatgtt tttgttcatg attctctaca ctgttgccct   1380

ggctgtattc ataagattcc agctccttca ggtgtttgat tccagcatgt agtatacatt   1440

gtatgtgtta aaaagaaatt tgcaactgtg aataaaagga cttctttaga agaagcttca   1500

tttaaaacat gaaaggataa tctgacttaa gaaacttttt gctaagaaaa ggtaatattt   1560

tattaaattt taaatttgtg ttgtcacaga aatacctgaa attcagtagt acttcattca   1620

attaattttg ttttctatta ttttgagtta tactgttttc aaagtcatta tgcagtatgt   1680

ataaacttat aagaattaaa ttgatgtgat aattttatgt ttttataatt aaatatagaa   1740

tctttatgat ttatgttaat tcattaattt agtgtaagaa gaaagttaag tctgaatgta   1800

aattcagtgt aagatgaaaa tttatcaata cttatgaaat taggctgggc gctgtggctc   1860

acacctgtaa tcccaacact ttgggaggct gaggtgggca gatcacttga ggtcaggagt   1920

tcgagaccag cctggccaac atggtgaaac cccgtcacta ctaaaaatac aaaaaataat   1980

tagccgggca tggtggttca cgcctggagt cccagctact tgggaggctg aggcaggaga   2040

atcgcttgaa cccaggaggc ggaggttgca gtgagccgag attgtgccac tgcactccac   2100

cctagagtaa gactccct                                                 2118


<210>  4548
<211>  349
<212>  PRT
<213>  Homosapiens

<400>  4548

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Ile Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Leu Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Leu Lys Asn Gly Leu Gly 
            340                 345                 


<210>  4549
<211>  2313
<212>  DNA
<213>  Homosapiens

<400>  4549
tgcccggcct tggatcactt ttttaaaatg ttattttctt ctattttaca aaaatgttac     60

aatgaaaatt tattacattt agattgaaaa aagtataact tttaatagaa aaataatctc    120

cttatttaat atgtatgttt ttaaatgtta atgaaataaa atgcttttct acttttggcc    180

ttttatatta ccagtcgacc tctcttttcc acggtcttct catgtgttta atgatgtcag    240

taactatcaa ccttattgtg tgtttcaagg attgagttaa tacagatgat gcgtttagaa    300

taatgcttga tgtaaacatt caatatattt tagatcttat gtttggctaa tctttttgat    360

ttactgatat attttcttat ttcattttaa agttatttaa atttataatt tatttattag    420

agtcctttag gaatgttaac ccttctcagt cacccgatgc aaatattttt cttgttggtt    480

atttgccttt acttttattt atttgttttg atatgtagat acatttacat tttttatgta    540

atatatcttt ttaaaaatgg tttctgcttt tcctgaacat gttttcagaa tttaaaattg    600

tatatggaaa acaaattaca tgaaagattt gagcatttca aaattttaaa cataaaagca    660

taaacgtaga taaaatgaag gtgtactatg atatcttcag ttttatcaga aatgatgtaa    720

aaattacaac ctctttaaaa agtagtgtta atcattaagt tagaaaatat atagctgggc    780

atggtggcag atgcctgtaa tcccagctac atgggaaggt gaggtgggag aatcgcttga    840

acccaggcag tggaggatgc agtgagccaa gatcatgcca ctgcacccca gcctgggtga    900

cagaacaaga ctccatctca agaaaaaaaa aaaagaaaaa tatatatatg aacttcagaa    960

tctgaggtca tatatagaca ggtctttccc ccgtttcctc tactttttct tgtagcttgg   1020

aattagtcag tttcatcatg ctataataag cttatctgaa aggcagtaaa gtgatatttt   1080

gtacaacttc attggctttt tgagaagaac atttttaggt tcttagtcct agaattctgc   1140

tgtttgcttg gaaaaagaaa gtaatacatt ttcttctatg aaggatttcc tcagcacacc   1200

attgcttctt tatctgacca ggatgcaaaa ccctctttca gcatggcgca tttggatggc   1260

aatactgagc cagggcttac attaggaggc tatttctgcc cacagtgtcg ggcaaagtac   1320

tgtgagctac ctgttgaatg taaaatctgt ggtcttactt tggtgtctgc tccccacttg   1380

gcacggtctt accatcattt gtttcctttg gatgcttttc aagaaattcc cctagaagaa   1440

tataatggag aaagattttg ttatggatgt cagggggaat tgaaagacca acatgtttat   1500

gtttgtgctg tgtgccaaaa tgttttctgt gtggactgtg atgtttttgt tcatgattct   1560

ctacactgtt gccctggctg tattcataag attccagctc cttcaggtgt ttgattccag   1620

catgtagtat acattgtatg tgttaaaaag aaatttgcaa ctgtgaataa aaggacttct   1680

ttagaagaag cttcatttaa aacatgaaag gataatctga cttaagaaac tttttgctaa   1740

gaaaaggtaa tattttatta aattttaaat ttgtgttgtc acagaaatac ctgaaattca   1800

gtagtacttc attcaattaa ttttgttttc tattattttg agttatactg ttttcaaagt   1860

cattatgcag tatgtataaa cttataagaa ttaaattgat gtgataattt tatgttttta   1920

taattaaata tagaatcttt atgatttatg ttaattcatt aatttagtgt aagaagaaag   1980

ttaagtctga atgtaaattc agtgtaagat gaaaatttat caatacttat gaaattaggc   2040

tgggcgctgt ggctcacacc tgtaatccca acactttggg aggctgaggt gggcagatca   2100

cttgaggtca ggagttcgag accagcctgg ccaacatggt gaaaccccgt cactactaaa   2160

aatacaaaaa ataattagcc gggcatggtg gttcacgcct ggagtcccag ctacttggga   2220

ggctgaggca ggagaatcgc ttgaacccag gaggcggagg ttgcagtgag ccgagattgt   2280

gccactgcac tccaccctag agtaagactc cct                                2313


<210>  4550
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  4550

Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
1               5                   10                  15      


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
            20                  25                  30          


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
        35                  40                  45              


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
    50                  55                  60                  


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
65                  70                  75                  80  


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
                85                  90                  95      


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
            100                 105                 110         


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
        115                 120             


<210>  4551
<211>  2181
<212>  DNA
<213>  Homosapiens

<400>  4551
tagggttcag tactatcctt gatttcaggt atccactggg ggtcttggaa tgtatcctct     60

gcagataaga ggggactact atagtctttg agaaagaagt gtgtgttact gttttgaagc    120

cacatctctg cactttaaag ctgatccata tgatattgcc acattttagt ttaaagttta    180

tccatatatt gttgtatttt ttattgtata ctctagactt tgtatgaaac aaacctacta    240

gaatgtaagc ttaatgatgt cgggaacatt gtcagtcttg tttatcactc tacccccaga    300

acttgagagt acttggtaaa tattaaatga atcaattaac aattttttga agtgcatagc    360

tcattttaga aaaatttgca ttaaagtgtt taaaatatac tcacaacctt tctttgcatt    420

gttgaaacaa atgagatatt ctatagtcta aatgtgtaat cctatgttta ctgttctttc    480

tgggtaaatt ttttggtagt ataatttgtt gtacctaatt ggagtgtatt ttatctttct    540

tttaagacac atgcctggac atacaagtcg agaagtacta atcatcttta gcagccttac    600

aacttgcgat ccatctaata tttatgatct aatcaaggta gaccaaaaaa tcaaaaccaa    660

agttataact gtaaagagaa ttctgtagca aattgattta tatatatatg tatttttgta    720

tgtgtgattc atctttgtgt tagatgtatt gaatttatta ctagttttca gagcattctt    780

tatttttcaa atacattaaa tcttaaatgt ttttcttctt tcctaaaact atctatctac    840

ttggatttta tgaagaccct aaaggcagct aaaattagag tatctgttat tggattgtct    900

gcagaagttc gcgtttgcac tgtacttgct cgtgaaactg gtggcacgta ccatgttatt    960

ttagatgaaa gccattacaa agagttgctc acacatcatc ttagtcctcc tcctgctagc   1020

tcaagttctg aatgctcact tattcgtatg ggatttcctc agcacaccat tgcttcttta   1080

tctgaccagg atgcaaaacc ctctttcagc atggcgcatt tggatggcaa tactgagcca   1140

gggcttacat taggaggcta tttctgccca cagtgtcggg caaagtactg tgagctacct   1200

gttgaatgta aaatctgtgg tcttactttg gtgtctgctc cccacttggc acggtcttac   1260

catcatttgt ttcctttgga tgcttttcaa gaaattcccc tagaagaata taatggagaa   1320

agattttgtt atggatgtca gggggaattg aaagaccaac atgtttatgt ttgtgctgtg   1380

tgccaaaatg ttttctgtgt ggactgtgat gtttttgttc atgattctct acactgttgc   1440

cctggctgta ttcataagat tccagctcct tcaggtgttt gattccagca tgtagtatac   1500

attgtatgtg ttaaaaagaa atttgcaact gtgaataaaa ggacttcttt agaagaagct   1560

tcatttaaaa catgaaagga taatctgact taagaaactt tttgctaaga aaaggtaata   1620

ttttattaaa ttttaaattt gtgttgtcac agaaatacct gaaattcagt agtacttcat   1680

tcaattaatt ttgttttcta ttattttgag ttatactgtt ttcaaagtca ttatgcagta   1740

tgtataaact tataagaatt aaattgatgt gataatttta tgtttttata attaaatata   1800

gaatctttat gatttatgtt aattcattaa tttagtgtaa gaagaaagtt aagtctgaat   1860

gtaaattcag tgtaagatga aaatttatca atacttatga aattaggctg ggcgctgtgg   1920

ctcacacctg taatcccaac actttgggag gctgaggtgg gcagatcact tgaggtcagg   1980

agttcgagac cagcctggcc aacatggtga aaccccgtca ctactaaaaa tacaaaaaat   2040

aattagccgg gcatggtggt tcacgcctgg agtcccagct acttgggagg ctgaggcagg   2100

agaatcgctt gaacccagga ggcggaggtt gcagtgagcc gagattgtgc cactgcactc   2160

caccctagag taagactccc t                                             2181


<210>  4552
<211>  210
<212>  PRT
<213>  Homosapiens

<400>  4552

Met Lys Thr Leu Lys Ala Ala Lys Ile Arg Val Ser Val Ile Gly Leu 
1               5                   10                  15      


Ser Ala Glu Val Arg Val Cys Thr Val Leu Ala Arg Glu Thr Gly Gly 
            20                  25                  30          


Thr Tyr His Val Ile Leu Asp Glu Ser His Tyr Lys Glu Leu Leu Thr 
        35                  40                  45              


His His Leu Ser Pro Pro Pro Ala Ser Ser Ser Ser Glu Cys Ser Leu 
    50                  55                  60                  


Ile Arg Met Gly Phe Pro Gln His Thr Ile Ala Ser Leu Ser Asp Gln 
65                  70                  75                  80  


Asp Ala Lys Pro Ser Phe Ser Met Ala His Leu Asp Gly Asn Thr Glu 
                85                  90                  95      


Pro Gly Leu Thr Leu Gly Gly Tyr Phe Cys Pro Gln Cys Arg Ala Lys 
            100                 105                 110         


Tyr Cys Glu Leu Pro Val Glu Cys Lys Ile Cys Gly Leu Thr Leu Val 
        115                 120                 125             


Ser Ala Pro His Leu Ala Arg Ser Tyr His His Leu Phe Pro Leu Asp 
    130                 135                 140                 


Ala Phe Gln Glu Ile Pro Leu Glu Glu Tyr Asn Gly Glu Arg Phe Cys 
145                 150                 155                 160 


Tyr Gly Cys Gln Gly Glu Leu Lys Asp Gln His Val Tyr Val Cys Ala 
                165                 170                 175     


Val Cys Gln Asn Val Phe Cys Val Asp Cys Asp Val Phe Val His Asp 
            180                 185                 190         


Ser Leu His Cys Cys Pro Gly Cys Ile His Lys Ile Pro Ala Pro Ser 
        195                 200                 205             


Gly Val 
    210 


<210>  4553
<211>  2056
<212>  DNA
<213>  Homosapiens

<400>  4553
tctagcggcg ccggtgagtc cgcgtgtgga agtctgtgag gcgcagaggt ggggcaggcc     60

gtctgactag ctaggcggct gggagcgttt tcgtggcggg gaacggaggt tgaattgccc    120

tgcctgggct catagggaag gaggatgtga aggagcttgt gaaggcagag gaagattatt    180

gaataataaa atacagtttt gaaaaaaatg gatgaagaac ctgaaagaac taagcgatgg    240

gaaggaggct atgaaagaac atgggagatt cttaaagaag atgaatctgg atcacttaaa    300

gctacaatag aagacattct attcaaggca aagagaaaaa gagtatttga gcaccatgga    360

caagttcgac ttggaatgat gcgccacctt tatgtggtag tagatggatc aagaacaatg    420

gaagaccaag atttaaagcc taatagactg acgtgtactt taaagttgtt ggaatacttt    480

gtagaggaat attttgatca aaatcctatt agtcagattg gaataattgt aactaagagt    540

aaaagagctg aaaaattgac tgaactttca ggaaacccaa gaaaacatat aacgtctttg    600

aaggaagctg tggatatgac ctgccatgga gagccatctc tttataattc cctaagcatg    660

gctatgcaga ctctaaaaca catgcctgga catacaagtc gagaagtact aatcatcttt    720

agcagcctta caacttgcga tccatctaat atttatgatc taatcaagac cctaaaggca    780

gctaaaatta gagtatctgt tattggattg tctgcagaag ttcgcgtttg cactgtactt    840

gctcgtgaaa ctggtggcac gtaccatgtt attttagatg aaagccatta caaagagttg    900

ctcacacatc atcttagtcc tcctcctgct agctcaagtt ctgaatgctc acttattcgt    960

atgggatgca aaaccctctt tcagcatggc gcatttggat ggcaatactg agccagggct   1020

tacattagga ggctatttct gcccacagtg tcgggcaaag tactgtgagc tacctgttga   1080

atgtaaaatc tgtggtctta ctttggtgtc tgctccccac ttggcacggt cttaccatca   1140

tttgtttcct ttggatgctt ttcaagaaat tcccctagaa gaatataatg gagaaagatt   1200

ttgttatgga tgtcaggggg aattgaaaga ccaacatgtt tatgtttgtg ctgtgtgcca   1260

aaatgttttc tgtgtggact gtgatgtttt tgttcatgat tctctacact gttgccctgg   1320

ctgtattcat aagattccag ctccttcagg tgtttgattc cagcatgtag tatacattgt   1380

atgtgttaaa aagaaatttg caactgtgaa taaaaggact tctttagaag aagcttcatt   1440

taaaacatga aaggataatc tgacttaaga aactttttgc taagaaaagg taatatttta   1500

ttaaatttta aatttgtgtt gtcacagaaa tacctgaaat tcagtagtac ttcattcaat   1560

taattttgtt ttctattatt ttgagttata ctgttttcaa agtcattatg cagtatgtat   1620

aaacttataa gaattaaatt gatgtgataa ttttatgttt ttataattaa atatagaatc   1680

tttatgattt atgttaattc attaatttag tgtaagaaga aagttaagtc tgaatgtaaa   1740

ttcagtgtaa gatgaaaatt tatcaatact tatgaaatta ggctgggcgc tgtggctcac   1800

acctgtaatc ccaacacttt gggaggctga ggtgggcaga tcacttgagg tcaggagttc   1860

gagaccagcc tggccaacat ggtgaaaccc cgtcactact aaaaatacaa aaaataatta   1920

gccgggcatg gtggttcacg cctggagtcc cagctacttg ggaggctgag gcaggagaat   1980

cgcttgaacc caggaggcgg aggttgcagt gagccgagat tgtgccactg cactccaccc   2040

tagagtaaga ctccct                                                   2056


<210>  4554
<211>  267
<212>  PRT
<213>  Homosapiens

<400>  4554

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Ile Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Leu Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Cys Lys Thr 
                245                 250                 255     


Leu Phe Gln His Gly Ala Phe Gly Trp Gln Tyr 
            260                 265         


<210>  4555
<211>  1958
<212>  DNA
<213>  Homosapiens

<400>  4555
ccggctgaga gtccttctag cggcgccggc tggagtgcag tggcacaacc ttggctcgct     60

ccagtgtcta cctcccaggt tcaagtgatt ctcctgcctc agcctcccga gtagctggga    120

ttacagatta ttgaataata aaatacagtt ttgaaaaaaa tggatgaaga acctgaaaga    180

actaagcgat gggaaggagg ctatgaaaga acatgggaga ttcttaaaga agatgaatct    240

ggatcactta aagctacaat agaagacatt ctattcaagg caaagagaaa aagatgcgcc    300

acctttatgt ggtagtagat ggatcaagaa caatggaaga ccaagattta aagcctaata    360

gactgacgtg tactttaaag attggaataa ttgtaactaa gagtaaaaga gctgaaaaat    420

tgactgaact ttcaggaaac ccaagaaaac atataacgtc tttgaaggaa gctgtggata    480

tgacctgcca tggagagcca tctctttata attccctaag catggctatg cagactctaa    540

aacacatgcc tggacataca agtcgagaag tactaatcat ctttagcagc cttacaactt    600

gcgatccatc taatatttat gatctaatca agaccctaaa ggcagctaaa attagagtat    660

ctgttattgg attgtctgca gaagttcgcg tttgcactgt acttgctcgt gaaactggtg    720

gcacgtacca tgttatttta gatgaaagcc attacaaaga gttgctcaca catcatctta    780

gtcctcctcc tgctagctca agttctgaat gctcacttat tcgtatggga tttcctcagc    840

acaccattgc ttctttatct gaccaggatg caaaaccctc tttcagcatg gcgcatttgg    900

atggcaatac tgagccaggg cttacattag gaggctattt ctgcccacag tgtcgggcaa    960

agtactgtga gctacctgtt gaatgtaaaa tctgtggtct tactttggtg tctgctcccc   1020

acttggcacg gtcttaccat catttgtttc ctttggatgc ttttcaagaa attcccctag   1080

aagaatataa tggagaaaga ttttgttatg gatgtcaggg ggaattgaaa gaccaacatg   1140

tttatgtttg tgctgtgtgc caaaatgttt tctgtgtgga ctgtgatgtt tttgttcatg   1200

attctctaca ctgttgccct ggctgtattc ataagattcc agctccttca ggtgtttgat   1260

tccagcatgt agtatacatt gtatgtgtta aaaagaaatt tgcaactgtg aataaaagga   1320

cttctttaga agaagcttca tttaaaacat gaaaggataa tctgacttaa gaaacttttt   1380

gctaagaaaa ggtaatattt tattaaattt taaatttgtg ttgtcacaga aatacctgaa   1440

attcagtagt acttcattca attaattttg ttttctatta ttttgagtta tactgttttc   1500

aaagtcatta tgcagtatgt ataaacttat aagaattaaa ttgatgtgat aattttatgt   1560

ttttataatt aaatatagaa tctttatgat ttatgttaat tcattaattt agtgtaagaa   1620

gaaagttaag tctgaatgta aattcagtgt aagatgaaaa tttatcaata cttatgaaat   1680

taggctgggc gctgtggctc acacctgtaa tcccaacact ttgggaggct gaggtgggca   1740

gatcacttga ggtcaggagt tcgagaccag cctggccaac atggtgaaac cccgtcacta   1800

ctaaaaatac aaaaaataat tagccgggca tggtggttca cgcctggagt cccagctact   1860

tgggaggctg aggcaggaga atcgcttgaa cccaggaggc ggaggttgca gtgagccgag   1920

attgtgccac tgcactccac cctagagtaa gactccct                           1958


<210>  4556
<211>  321
<212>  PRT
<213>  Homosapiens

<400>  4556

Met Arg His Leu Tyr Val Val Val Asp Gly Ser Arg Thr Met Glu Asp 
1               5                   10                  15      


Gln Asp Leu Lys Pro Asn Arg Leu Thr Cys Thr Leu Lys Ile Gly Ile 
            20                  25                  30          


Ile Val Thr Lys Ser Lys Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly 
        35                  40                  45              


Asn Pro Arg Lys His Ile Thr Ser Leu Lys Glu Ala Val Asp Met Thr 
    50                  55                  60                  


Cys His Gly Glu Pro Ser Leu Tyr Asn Ser Leu Ser Met Ala Met Gln 
65                  70                  75                  80  


Thr Leu Lys His Met Pro Gly His Thr Ser Arg Glu Val Leu Ile Ile 
                85                  90                  95      


Phe Ser Ser Leu Thr Thr Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile 
            100                 105                 110         


Lys Thr Leu Lys Ala Ala Lys Ile Arg Val Ser Val Ile Gly Leu Ser 
        115                 120                 125             


Ala Glu Val Arg Val Cys Thr Val Leu Ala Arg Glu Thr Gly Gly Thr 
    130                 135                 140                 


Tyr His Val Ile Leu Asp Glu Ser His Tyr Lys Glu Leu Leu Thr His 
145                 150                 155                 160 


His Leu Ser Pro Pro Pro Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile 
                165                 170                 175     


Arg Met Gly Phe Pro Gln His Thr Ile Ala Ser Leu Ser Asp Gln Asp 
            180                 185                 190         


Ala Lys Pro Ser Phe Ser Met Ala His Leu Asp Gly Asn Thr Glu Pro 
        195                 200                 205             


Gly Leu Thr Leu Gly Gly Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr 
    210                 215                 220                 


Cys Glu Leu Pro Val Glu Cys Lys Ile Cys Gly Leu Thr Leu Val Ser 
225                 230                 235                 240 


Ala Pro His Leu Ala Arg Ser Tyr His His Leu Phe Pro Leu Asp Ala 
                245                 250                 255     


Phe Gln Glu Ile Pro Leu Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr 
            260                 265                 270         


Gly Cys Gln Gly Glu Leu Lys Asp Gln His Val Tyr Val Cys Ala Val 
        275                 280                 285             


Cys Gln Asn Val Phe Cys Val Asp Cys Asp Val Phe Val His Asp Ser 
    290                 295                 300                 


Leu His Cys Cys Pro Gly Cys Ile His Lys Ile Pro Ala Pro Ser Gly 
305                 310                 315                 320 


Val 
    


<210>  4557
<211>  1978
<212>  DNA
<213>  Homosapiens

<400>  4557
tgggagcgtt ttcgtggcgg ggaacggagg ttgaattgcc ctgcctgggc tcatagggaa     60

ggaggatgtg aaggagcttg tgaaggcaga ggaagattat tgaataataa aatacagttt    120

tgaaaaaaat ggatgaagaa cctgaaagaa ctaagcgatg ggaaggaggc tatgaaagaa    180

catgggagat tcttaaagaa gatgaatctg gatcacttaa agctacaata gaagacattc    240

tattcaaggc aaagagaaaa agatgcgcca cctttatgtg gtagtagatg gatcaagaac    300

aatggaagac caagatttaa agcctaatag actgacgtgt actttaaagt tgttggaata    360

ctttgtagag gaatattttg atcaaaatcc tattagtcag attggaataa ttgtaactaa    420

gagtaaaaga gctgaaaaat tgactgaact ttcaggaaac ccaagaaaac atataacgtc    480

tttgaaggaa gctgtggata tgacctgcca tggagagcca tctctttata attccctaag    540

catggctatg cagactctaa aacacatgcc tggacataca agtcgagaag tactaatcat    600

ctttagcagc cttacaactt gcgatccatc taatatttat gatctaatca agaccctaaa    660

ggcagctaaa attagagtat ctgttattgg attgtctgca gaagttcgcg tttgcactgt    720

acttgctcgt gaaactggtg gcacgtacca tgttatttta gatgaaagcc attacaaaga    780

gttgctcaca catcatctta gtcctcctcc tgctagctca agttctgaat gctcacttat    840

tcgtatggga tttcctcagc acaccattgc ttctttatct gaccaggatg caaaaccctc    900

tttcagcatg gcgcatttgg atggcaatac tgagccaggg cttacattag gaggctattt    960

ctgcccacag tgtcgggcaa agtactgtga gctacctgtt gaatgtaaaa tctgtggtct   1020

tactttggtg tctgctcccc acttggcacg gtcttaccat catttgtttc ctttggatgc   1080

ttttcaagaa attcccctag aagaatataa tggagaaaga ttttgttatg gatgtcaggg   1140

ggaattgaaa gaccaacatg tttatgtttg tgctgtgtgc caaaatgttt tctgtgtgga   1200

ctgtgatgtt tttgttcatg attctctaca ctgttgccct ggctgtattc ataagattcc   1260

agctccttca ggtgtttgat tccagcatgt agtatacatt gtatgtgtta aaaagaaatt   1320

tgcaactgtg aataaaagga cttctttaga agaagcttca tttaaaacat gaaaggataa   1380

tctgacttaa gaaacttttt gctaagaaaa ggtaatattt tattaaattt taaatttgtg   1440

ttgtcacaga aatacctgaa attcagtagt acttcattca attaattttg ttttctatta   1500

ttttgagtta tactgttttc aaagtcatta tgcagtatgt ataaacttat aagaattaaa   1560

ttgatgtgat aattttatgt ttttataatt aaatatagaa tctttatgat ttatgttaat   1620

tcattaattt agtgtaagaa gaaagttaag tctgaatgta aattcagtgt aagatgaaaa   1680

tttatcaata cttatgaaat taggctgggc gctgtggctc acacctgtaa tcccaacact   1740

ttgggaggct gaggtgggca gatcacttga ggtcaggagt tcgagaccag cctggccaac   1800

atggtgaaac cccgtcacta ctaaaaatac aaaaaataat tagccgggca tggtggttca   1860

cgcctggagt cccagctact tgggaggctg aggcaggaga atcgcttgaa cccaggaggc   1920

ggaggttgca gtgagccgag attgtgccac tgcactccac cctagagtaa gactccct     1978


<210>  4558
<211>  338
<212>  PRT
<213>  Homosapiens

<400>  4558

Met Arg His Leu Tyr Val Val Val Asp Gly Ser Arg Thr Met Glu Asp 
1               5                   10                  15      


Gln Asp Leu Lys Pro Asn Arg Leu Thr Cys Thr Leu Lys Leu Leu Glu 
            20                  25                  30          


Tyr Phe Val Glu Glu Tyr Phe Asp Gln Asn Pro Ile Ser Gln Ile Gly 
        35                  40                  45              


Ile Ile Val Thr Lys Ser Lys Arg Ala Glu Lys Leu Thr Glu Leu Ser 
    50                  55                  60                  


Gly Asn Pro Arg Lys His Ile Thr Ser Leu Lys Glu Ala Val Asp Met 
65                  70                  75                  80  


Thr Cys His Gly Glu Pro Ser Leu Tyr Asn Ser Leu Ser Met Ala Met 
                85                  90                  95      


Gln Thr Leu Lys His Met Pro Gly His Thr Ser Arg Glu Val Leu Ile 
            100                 105                 110         


Ile Phe Ser Ser Leu Thr Thr Cys Asp Pro Ser Asn Ile Tyr Asp Leu 
        115                 120                 125             


Ile Lys Thr Leu Lys Ala Ala Lys Ile Arg Val Ser Val Ile Gly Leu 
    130                 135                 140                 


Ser Ala Glu Val Arg Val Cys Thr Val Leu Ala Arg Glu Thr Gly Gly 
145                 150                 155                 160 


Thr Tyr His Val Ile Leu Asp Glu Ser His Tyr Lys Glu Leu Leu Thr 
                165                 170                 175     


His His Leu Ser Pro Pro Pro Ala Ser Ser Ser Ser Glu Cys Ser Leu 
            180                 185                 190         


Ile Arg Met Gly Phe Pro Gln His Thr Ile Ala Ser Leu Ser Asp Gln 
        195                 200                 205             


Asp Ala Lys Pro Ser Phe Ser Met Ala His Leu Asp Gly Asn Thr Glu 
    210                 215                 220                 


Pro Gly Leu Thr Leu Gly Gly Tyr Phe Cys Pro Gln Cys Arg Ala Lys 
225                 230                 235                 240 


Tyr Cys Glu Leu Pro Val Glu Cys Lys Ile Cys Gly Leu Thr Leu Val 
                245                 250                 255     


Ser Ala Pro His Leu Ala Arg Ser Tyr His His Leu Phe Pro Leu Asp 
            260                 265                 270         


Ala Phe Gln Glu Ile Pro Leu Glu Glu Tyr Asn Gly Glu Arg Phe Cys 
        275                 280                 285             


Tyr Gly Cys Gln Gly Glu Leu Lys Asp Gln His Val Tyr Val Cys Ala 
    290                 295                 300                 


Val Cys Gln Asn Val Phe Cys Val Asp Cys Asp Val Phe Val His Asp 
305                 310                 315                 320 


Ser Leu His Cys Cys Pro Gly Cys Ile His Lys Ile Pro Ala Pro Ser 
                325                 330                 335     


Gly Val 
        


<210>  4559
<211>  2043
<212>  DNA
<213>  Homosapiens

<400>  4559
tctagcggcg ccggtgagtc cgcgtgtgga agtctgtgag gcgcagaggt ggggcaggcc     60

gtctgactag ctaggcggct gggagcgttt tcgtggcggg gaacggaggt tgaattgccc    120

tgcctgggct catagggaag gaggatgtga aggagcttgt gaaggcagag gaagattatt    180

gaataataaa atacagtttt gaaaaaaatg gatgaagaac ctgaaagaac taagcgatgg    240

gaaggaggct atgaaagaac atgggagatt cttaaagaag atgaatctgg atcacttaaa    300

gctacaatag aagacattct attcaaggca aagagaaaaa gagtatttga gcaccatgga    360

caagttcgac ttggaatgat gcgccacctt tatgtggtag tagatggatc aagaacaatg    420

gaagaccaag atttaaagcc taatagactg acgtgtactt taaagattgg aataattgta    480

actaagagta aaagagctga aaaattgact gaactttcag gaaacccaag aaaacatata    540

acgtctttga aggaagctgt ggatatgacc tgccatggag agccatctct ttataattcc    600

ctaagcatgg ctatgcagac tctaaaacac atgcctggac atacaagtcg agaagtacta    660

atcatcttta gcagccttac aacttgcgat ccatctaata tttatgatct aatcaagacc    720

ctaaaggcag ctaaaattag agtatctgtt attggattgt ctgcagaagt tcgcgtttgc    780

actgtacttg ctcgtgaaac tggtggcacg taccatgtta ttttagatga aagccattac    840

aaagagttgc tcacacatca tcttagtcct cctcctgcta gctcaagttc tgaatgctca    900

cttattcgta tgggatttcc tcagcacacc attgcttctt tatctgacca ggatgcaaaa    960

ccctctttca gcatggcgca tttggatggc aatactgagc cagggcttac attaggaggc   1020

tatttctgcc cacagtgtcg ggcaaagtac tgtgagctac ctgttgaatg taaaatctgt   1080

ggtcttactt tggtgtctgc tccccacttg gcacggtctt accatcattt gtttcctttg   1140

gatgcttttc aagaaattcc cctagaagaa tataatggag aaagattttg ttatggatgt   1200

cagggggaat tgaaagacca acatgtttat gtttgtgctg tgtgccaaaa tgttttctgt   1260

gtggactgtg atgtttttgt tcatgattct ctacactgtt gccctggctg tattcataag   1320

attccagctc cttcaggtgt ttgattccag catgtagtat acattgtatg tgttaaaaag   1380

aaatttgcaa ctgtgaataa aaggacttct ttagaagaag cttcatttaa aacatgaaag   1440

gataatctga cttaagaaac tttttgctaa gaaaaggtaa tattttatta aattttaaat   1500

ttgtgttgtc acagaaatac ctgaaattca gtagtacttc attcaattaa ttttgttttc   1560

tattattttg agttatactg ttttcaaagt cattatgcag tatgtataaa cttataagaa   1620

ttaaattgat gtgataattt tatgttttta taattaaata tagaatcttt atgatttatg   1680

ttaattcatt aatttagtgt aagaagaaag ttaagtctga atgtaaattc agtgtaagat   1740

gaaaatttat caatacttat gaaattaggc tgggcgctgt ggctcacacc tgtaatccca   1800

acactttggg aggctgaggt gggcagatca cttgaggtca ggagttcgag accagcctgg   1860

ccaacatggt gaaaccccgt cactactaaa aatacaaaaa ataattagcc gggcatggtg   1920

gttcacgcct ggagtcccag ctacttggga ggctgaggca ggagaatcgc ttgaacccag   1980

gaggcggagg ttgcagtgag ccgagattgt gccactgcac tccaccctag agtaagactc   2040

cct                                                                 2043


<210>  4560
<211>  378
<212>  PRT
<213>  Homosapiens

<400>  4560

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Ile Gly Ile Ile Val Thr Lys Ser Lys Arg 
                85                  90                  95      


Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile Thr 
            100                 105                 110         


Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser Leu 
        115                 120                 125             


Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro Gly 
    130                 135                 140                 


His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr Cys 
145                 150                 155                 160 


Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala Lys 
                165                 170                 175     


Ile Arg Val Ser Val Ile Gly Leu Ser Ala Glu Val Arg Val Cys Thr 
            180                 185                 190         


Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp Glu 
        195                 200                 205             


Ser His Tyr Lys Glu Leu Leu Thr His His Leu Ser Pro Pro Pro Ala 
    210                 215                 220                 


Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln His 
225                 230                 235                 240 


Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser Met 
                245                 250                 255     


Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly Tyr 
            260                 265                 270         


Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu Cys 
        275                 280                 285             


Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg Ser 
    290                 295                 300                 


Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu Glu 
305                 310                 315                 320 


Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu Lys 
                325                 330                 335     


Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys Val 
            340                 345                 350         


Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly Cys 
        355                 360                 365             


Ile His Lys Ile Pro Ala Pro Ser Gly Val 
    370                 375             


<210>  4561
<211>  2032
<212>  DNA
<213>  Homosapiens

<400>  4561
ttctagcggc gccggctgga gtgcagtggc acaaccttgg ctcgctccag tgtctacctc     60

ccaggttcaa gtgattctcc tgcctcagcc tcccgagtag ctgggattac agattattga    120

ataataaaat acagttttga aaaaaatgga tgaagaacct gaaagaacta agcgatggga    180

aggaggctat gaaagaacat gggagattct taaagaagat gaatctggat cacttaaagc    240

tacaatagaa gacattctat tcaaggcaaa gagaaaaaga gtatttgagc accatggaca    300

agttcgactt ggaatgatgc gccaccttta tgtggtagta gatggatcaa gaacaatgga    360

agaccaagat ttaaagccta atagactgac gtgtacttta aagttgttgg aatactttgt    420

agaggaatat tttgatcaaa atcctattag tcagattgga ataattgtaa ctaagagtaa    480

aagagctgaa aaattgactg aactttcagg aaacccaaga aaacatataa cgtctttgaa    540

ggaagctgtg gatatgacct gccatggaga gccatctctt tataattccc taagcatggc    600

tatgcagact ctaaaacaca tgcctggaca tacaagtcga gaagtactaa tcatctttag    660

cagccttaca acttgcgatc catctaatat ttatgatcta atcaagaccc taaaggcagc    720

taaaattaga gtatctgtta ttggattgtc tgcagaagtt cgcgtttgca ctgtacttgc    780

tcgtgaaact ggtggcacgt accatgttat tttagatgaa agccattaca aagagttgct    840

cacacatcat cttagtcctc ctcctgctag ctcaagttct gaatgctcac ttattcgtat    900

gggatttcct cagcacacca ttgcttcttt atctgaccag gatgcaaaac cctctttcag    960

catggcgcat ttggatggca atactgagcc agggcttaca ttaggaggct atttctgccc   1020

acagtgtcgg gcaaagtact gtgagctacc tgttgaatgt aaaatctgtg gtcttacttt   1080

ggtgtctgct ccccacttgg cacggtctta ccatcatttg tttcctttgg atgcttttca   1140

agaaattccc ctagaagaat ataatggaga aagattttgt tatggatgtc agggggaatt   1200

gaaagaccaa catgtttatg tttgtgctgt gtgccaaaat gttttctgtg tggactgtga   1260

tgtttttgtt catgattctc tacactgttg ccctggctgt attcataaga ttccagctcc   1320

ttcaggtgtt tgattccagc atgtagtata cattgtatgt gttaaaaaga aatttgcaac   1380

tgtgaataaa aggacttctt tagaagaagc ttcatttaaa acatgaaagg ataatctgac   1440

ttaagaaact ttttgctaag aaaaggtaat attttattaa attttaaatt tgtgttgtca   1500

cagaaatacc tgaaattcag tagtacttca ttcaattaat tttgttttct attattttga   1560

gttatactgt tttcaaagtc attatgcagt atgtataaac ttataagaat taaattgatg   1620

tgataatttt atgtttttat aattaaatat agaatcttta tgatttatgt taattcatta   1680

atttagtgta agaagaaagt taagtctgaa tgtaaattca gtgtaagatg aaaatttatc   1740

aatacttatg aaattaggct gggcgctgtg gctcacacct gtaatcccaa cactttggga   1800

ggctgaggtg ggcagatcac ttgaggtcag gagttcgaga ccagcctggc caacatggtg   1860

aaaccccgtc actactaaaa atacaaaaaa taattagccg ggcatggtgg ttcacgcctg   1920

gagtcccagc tacttgggag gctgaggcag gagaatcgct tgaacccagg aggcggaggt   1980

tgcagtgagc cgagattgtg ccactgcact ccaccctaga gtaagactcc ct           2032


<210>  4562
<211>  395
<212>  PRT
<213>  Homosapiens

<400>  4562

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Ile Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Leu Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
            340                 345                 350         


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
        355                 360                 365             


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
    370                 375                 380                 


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
385                 390                 395 


<210>  4563
<211>  1999
<212>  DNA
<213>  Homosapiens

<400>  4563
tgacttccgg ggcgccccta aagcggcgga gaggagtgtc gggctgagtt tccggctgag     60

agtccttcta gcggcgccga ttattgaata ataaaataca gttttgaaaa aaatggatga    120

agaacctgaa agaactaagc gatgggaagg aggctatgaa agaacatggg agattcttaa    180

agaagatgaa tctggatcac ttaaagctac aatagaagac attctattca aggcaaagag    240

aaaaagagta tttgagcacc atggacaagt tcgacttgga atgatgcgcc acctttatgt    300

ggtagtagat ggatcaagaa caatggaaga ccaagattta aagcctaata gactgacgtg    360

tactttaaag ttgttggaat actttgtaga ggaatatttt gatcaaaatc ctattagtca    420

gattggaata attgtaacta agagtaaaag agctgaaaaa ttgactgaac tttcaggaaa    480

cccaagaaaa catataacgt ctttgaagga agctgtggat atgacctgcc atggagagcc    540

atctctttat aattccctaa gcatggctat gcagactcta aaacacatgc ctggacatac    600

aagtcgagaa gtactaatca tctttagcag ccttacaact tgcgatccat ctaatattta    660

tgatctaatc aagaccctaa aggcagctaa aattagagta tctgttattg gattgtctgc    720

agaagttcgc gtttgcactg tacttgctcg tgaaactggt ggcacgtacc atgttatttt    780

agatgaaagc cattacaaag agttgctcac acatcatctt agtcctcctc ctgctagctc    840

aagttctgaa tgctcactta ttcgtatggg atttcctcag cacaccattg cttctttatc    900

tgaccaggat gcaaaaccct ctttcagcat ggcgcatttg gatggcaata ctgagccagg    960

gcttacatta ggaggctatt tctgcccaca gtgtcgggca aagtactgtg agctacctgt   1020

tgaatgtaaa atctgtggtc ttactttggt gtctgctccc cacttggcac ggtcttacca   1080

tcatttgttt cctttggatg cttttcaaga aattccccta gaagaatata atggagaaag   1140

attttgttat ggatgtcagg gggaattgaa agaccaacat gtttatgttt gtgctgtgtg   1200

ccaaaatgtt ttctgtgtgg actgtgatgt ttttgttcat gattctctac actgttgccc   1260

tggctgtatt cataagattc cagctccttc aggtgtttga ttccagcatg tagtatacat   1320

tgtatgtgtt aaaaagaaat ttgcaactgt gaataaaagg acttctttag aagaagcttc   1380

atttaaaaca tgaaaggata atctgactta agaaactttt tgctaagaaa aggtaatatt   1440

ttattaaatt ttaaatttgt gttgtcacag aaatacctga aattcagtag tacttcattc   1500

aattaatttt gttttctatt attttgagtt atactgtttt caaagtcatt atgcagtatg   1560

tataaactta taagaattaa attgatgtga taattttatg tttttataat taaatataga   1620

atctttatga tttatgttaa ttcattaatt tagtgtaaga agaaagttaa gtctgaatgt   1680

aaattcagtg taagatgaaa atttatcaat acttatgaaa ttaggctggg cgctgtggct   1740

cacacctgta atcccaacac tttgggaggc tgaggtgggc agatcacttg aggtcaggag   1800

ttcgagacca gcctggccaa catggtgaaa ccccgtcact actaaaaata caaaaaataa   1860

ttagccgggc atggtggttc acgcctggag tcccagctac ttgggaggct gaggcaggag   1920

aatcgcttga acccaggagg cggaggttgc agtgagccga gattgtgcca ctgcactcca   1980

ccctagagta agactccct                                                1999


<210>  4564
<211>  395
<212>  PRT
<213>  Homosapiens

<400>  4564

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Ile Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Leu Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
            340                 345                 350         


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
        355                 360                 365             


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
    370                 375                 380                 


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
385                 390                 395 


<210>  4565
<211>  2181
<212>  DNA
<213>  Homosapiens

<400>  4565
cggtgagtcc gcgtgtggaa gtctgtgagg cgcagaggtg gggcaggccg tctgactagc     60

taggcggctg ggagcgtttt cgtggcgggg aacggaggtt gaattgccct gcctgggctc    120

atagggaagg aggatgtgaa ggagcttgtg aaggcagagg aaggctggag tgcagtggca    180

caaccttggc tcgctccagt gtctacctcc caggttcaag tgattctcct gcctcagcct    240

cccgagtagc tgggattaca gattattgaa taataaaata cagttttgaa aaaaatggat    300

gaagaacctg aaagaactaa gcgatgggaa ggaggctatg aaagaacatg ggagattctt    360

aaagaagatg aatctggatc acttaaagct acaatagaag acattctatt caaggcaaag    420

agaaaaagag tatttgagca ccatggacaa gttcgacttg gaatgatgcg ccacctttat    480

gtggtagtag atggatcaag aacaatggaa gaccaagatt taaagcctaa tagactgacg    540

tgtactttaa agttgttgga atactttgta gaggaatatt ttgatcaaaa tcctattagt    600

cagattggaa taattgtaac taagagtaaa agagctgaaa aattgactga actttcagga    660

aacccaagaa aacatataac gtctttgaag gaagctgtgg atatgacctg ccatggagag    720

ccatctcttt ataattccct aagcatggct atgcagactc taaaacacat gcctggacat    780

acaagtcgag aagtactaat catctttagc agccttacaa cttgcgatcc atctaatatt    840

tatgatctaa tcaagaccct aaaggcagct aaaattagag tatctgttat tggattgtct    900

gcagaagttc gcgtttgcac tgtacttgct cgtgaaactg gtggcacgta ccatgttatt    960

ttagatgaaa gccattacaa agagttgctc acacatcatc ttagtcctcc tcctgctagc   1020

tcaagttctg aatgctcact tattcgtatg ggatttcctc agcacaccat tgcttcttta   1080

tctgaccagg atgcaaaacc ctctttcagc atggcgcatt tggatggcaa tactgagcca   1140

gggcttacat taggaggcta tttctgccca cagtgtcggg caaagtactg tgagctacct   1200

gttgaatgta aaatctgtgg tcttactttg gtgtctgctc cccacttggc acggtcttac   1260

catcatttgt ttcctttgga tgcttttcaa gaaattcccc tagaagaata taatggagaa   1320

agattttgtt atggatgtca gggggaattg aaagaccaac atgtttatgt ttgtgctgtg   1380

tgccaaaatg ttttctgtgt ggactgtgat gtttttgttc atgattctct acactgttgc   1440

cctggctgta ttcataagat tccagctcct tcaggtgttt gattccagca tgtagtatac   1500

attgtatgtg ttaaaaagaa atttgcaact gtgaataaaa ggacttcttt agaagaagct   1560

tcatttaaaa catgaaagga taatctgact taagaaactt tttgctaaga aaaggtaata   1620

ttttattaaa ttttaaattt gtgttgtcac agaaatacct gaaattcagt agtacttcat   1680

tcaattaatt ttgttttcta ttattttgag ttatactgtt ttcaaagtca ttatgcagta   1740

tgtataaact tataagaatt aaattgatgt gataatttta tgtttttata attaaatata   1800

gaatctttat gatttatgtt aattcattaa tttagtgtaa gaagaaagtt aagtctgaat   1860

gtaaattcag tgtaagatga aaatttatca atacttatga aattaggctg ggcgctgtgg   1920

ctcacacctg taatcccaac actttgggag gctgaggtgg gcagatcact tgaggtcagg   1980

agttcgagac cagcctggcc aacatggtga aaccccgtca ctactaaaaa tacaaaaaat   2040

aattagccgg gcatggtggt tcacgcctgg agtcccagct acttgggagg ctgaggcagg   2100

agaatcgctt gaacccagga ggcggaggtt gcagtgagcc gagattgtgc cactgcactc   2160

caccctagag taagactccc t                                             2181


<210>  4566
<211>  395
<212>  PRT
<213>  Homosapiens

<400>  4566

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Ile Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Leu Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
            340                 345                 350         


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
        355                 360                 365             


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
    370                 375                 380                 


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
385                 390                 395 


<210>  4567
<211>  1793
<212>  DNA
<213>  Homosapiens

<400>  4567
gcaaagccag ctgggctcct gagtccggtg ggtacttgga gaacttacta cgtctagctg     60

gaggattgta aatgcaccaa tcagcatgct gtgtctagct caagattttc tccatcccct    120

tattttgggc cagtggctgt cattacatat gagatgagtc tcttgaagac tacagatgaa    180

ctcaagctcc atgaggagat gtttcattgt cgagagcagt catgatggcc tgcactccac    240

acaatgcaac agagtgaaag agcaggttct gcttctttgg tgtagtcctg aagcttccta    300

agaaacttca catcaggtga tggataggag caaccctgta aaaccagcct tagactattt    360

ttcaaacagg ctggtgaatt accagatctc cgtcaagtgc agtaaccagt tcaagttgga    420

agtgtgtctt ttgaatgcag agaacaaagt cgtggacaac caggctggga cccagggcca    480

gctgaaggtg ctgggtgcca acctctggtg gccgtacctg atgcacgaac accccgccta    540

cctgtactcc tgggaggatg gtgattgctc acaccaaagc cttggacccc tcccagcctg    600

tgacctttgg gaccaactcc acctacgcag cagacaaggg ggctctgtat gtggatgtga    660

tccgtgtgaa cagctactac tcttggtatc gcaactacgg gcacctggag ttgattcggc    720

tgcagctggc cgcccagttt gagaattggt gtgagacatc acaatcccat tattcagagc    780

gcgtatggag tggaaacgct tgtagggttt caccagggct ggtgaattac cagatctccg    840

tcaagtgcag taaccagttc aagttggaag tatgtctttt gaatgcagaa aacaaagtcg    900

tggacaacca ggctgggacc cagggccagc tgaaggtgct ggtgccaacc tctggtggcc    960

gtacctgatg cacgaacacc ccgcctacct gtactcgtgg gaggatggtg attgctcaca   1020

ccaaagcctt ggacccctcc cagcctgtga cctttgggac caactccacc tacgcagcag   1080

acaagggggc tctgtatgtg gatgtgatcc gtgtgaacag ctactactct tggtatcgca   1140

actacgggca cctggagttg attcggctgc aggccctgca gctggccgcc cagtttgtga   1200

attggtgtaa gacatcacaa tcccattatt cagagcgcgt atggagtgga aacgcttgta   1260

gggtttcacc agtctttccc agggaactcc gatgaagtgt tccaacaaaa tgagcgagtg   1320

aaccaagaag aggatgacat tagatccagg agatacaaca gaggagataa tctccaggat   1380

gcctgtgaag aaagatccct ggatcccagg atgattatag gacaagttgt tcataatcca   1440

gcaggccaga agacttccag ggaaactcat ttcaagatga aaatggacca gccgcagtgg   1500

ctcacgcctg taataccagc actttgggag gctgaggcgg gcggatcact tgaggtcaag   1560

agtttgaaac tagcctggcc aacgtggcaa aactccatct ctattaaaga tacaaaaatt   1620

agccaggcat agtggtgcat gcctgtagtc ccagctactt gggatgctga ggcaggaaga   1680

attgcttgaa cctgggaggc agagtctgcg gtgaccgaga tcatgccact gcactccagc   1740

ctgggtgaca gagccagact ccgtctctac taaaaaaaaa aaaaaaaaaa aaa          1793


<210>  4568
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  4568

Met Asp Arg Ser Asn Pro Val Lys Pro Ala Leu Asp Tyr Phe Ser Asn 
1               5                   10                  15      


Arg Leu Val Asn Tyr Gln Ile Ser Val Lys Cys Ser Asn Gln Phe Lys 
            20                  25                  30          


Leu Glu Val Cys Leu Leu Asn Ala Glu Asn Lys Val Val Asp Asn Gln 
        35                  40                  45              


Ala Gly Thr Gln Gly Gln Leu Lys Val Leu Gly Ala Asn Leu Trp Trp 
    50                  55                  60                  


Pro Tyr Leu Met His Glu His Pro Ala Tyr Leu Tyr Ser Trp Glu Asp 
65                  70                  75                  80  


Gly Asp Cys Ser His Gln Ser Leu Gly Pro Leu Pro Ala Cys Asp Leu 
                85                  90                  95      


Trp Asp Gln Leu His Leu Arg Ser Arg Gln Gly Gly Ser Val Cys Gly 
            100                 105                 110         


Cys Asp Pro Cys Glu Gln Leu Leu Leu Leu Val Ser Gln Leu Arg Ala 
        115                 120                 125             


Pro Gly Val Asp Ser Ala Ala Ala Gly Arg Pro Val 
    130                 135                 140 


<210>  4569
<211>  1843
<212>  DNA
<213>  Homosapiens

<400>  4569
cagcattctc ctctattaga ctagaactgt ggataaacct cagatgtgaa tttcttcgga     60

gtaagaaatc ctcagaggaa attacccagt atattcaaag ctacaaggga tttgttgaca    120

taacgggaga acattttgtg aattcctggg tccagagaga attacctatg gcatcagctt    180

attgcaatga cagcatcttt gcttacgaag aactacggct ggactctttt aaggactggc    240

cccgggaatc agctgtggga gttgcagcac tggccaaagc aggtcttttc tacacaggta    300

taaaggacat cgtccagtgc ttttcctgtg gagggtgttt agagaaatgg caggaaggtg    360

atgacccatt agacgatcac accagatgtt ttcccaaatg gagtctcact gtgttgccca    420

ggctggagtg cagtggcatg atctcggctc actgtagact ctgcctccca ggttcaagca    480

attcttcctg cctcagcatc ccaagtagct gggactacag gcatgcacca ctatgcttgg    540

ctaatttttg tatttttaat agagatggag ttttgccacg ttggccaggc tagtttcaaa    600

ctcctgacct caagtgatcc gcctgcctca gcctcccaaa gtgctggtat tacaggcgtg    660

agccactgcg gctggtccat tttcatcttg gaggagtcat ccatcatttt cacctccttg    720

aatgagtttc cctggaagtc ttctggcctg ctggattatg aacaacttgt cctataatca    780

tcctgggatc cagggatctt tcttcacagg catcctggag attatctcct ctgttgtatc    840

tcctggatct aatgtcatcc tcttcttggt tcactcgctc attttgttgg aacacttcat    900

cggagttccc tgggaaagac tgcataagaa atacacactt ttagttgcat ataatgcata    960

tacagacata tagatctatc tagatatatg tttttcctgt attctcacac ttatttgata   1020

gtttagctag gtgtagaatt ataggttgga agtcatttta attctaaatt gtagaggcac   1080

tgctacattt ctactggttc ctaatgtgct gtcgagaagt tccatgcctt tctgcttgtc   1140

aatcctttta ctgcaaacaa aatttttttt tttcctgtgc tggaagcttt cagaaaaata   1200

tctgttctaa aattttacga agaaatattt cttttctatg aatctttaaa cttaattttt   1260

tttacccatc aaactcttta gaaatgttta attgcaagaa gaaatttgtg ttttcactat   1320

gtaattagta agagtttttt tttttagaaa tgaatatgaa cacatacaga ttttaaaatg   1380

aatgcttcct gctcatttgt atagtggtaa aaacaaaaat aaaacaaaat gaatacttct   1440

atctaatttt attgccttga aggtattttg atagcagtag ttacctcatt tttctttctt   1500

atttgggctt agtgtataat aaattattga gaacaatggg gacattctac ttaattcttg   1560

gaaggataag ctaggatgca gtctagtctt atttagaact tactctggaa tcgatcaact   1620

cccttttata ctattattat tattattagt tttagtgttt tgttgttgtt gtttttgaga   1680

tggagtctca ctctgtcacc caggctggag tgcagtggcg tgatctcggc tcactgcaac   1740

ctccgcctcc cgggttcaag cgattctcct gcctcagcct cccaagtagc tgggattaca   1800

ggtacctccc caccatgcct ggctaatttt ttgtactttt agt                     1843


<210>  4570
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  4570

Met Ala Ser Ala Tyr Cys Asn Asp Ser Ile Phe Ala Tyr Glu Glu Leu 
1               5                   10                  15      


Arg Leu Asp Ser Phe Lys Asp Trp Pro Arg Glu Ser Ala Val Gly Val 
            20                  25                  30          


Ala Ala Leu Ala Lys Ala Gly Leu Phe Tyr Thr Gly Ile Lys Asp Ile 
        35                  40                  45              


Val Gln Cys Phe Ser Cys Gly Gly Cys Leu Glu Lys Trp Gln Glu Gly 
    50                  55                  60                  


Asp Asp Pro Leu Asp Asp His Thr Arg Cys Phe Pro Lys Trp Ser Leu 
65                  70                  75                  80  


Thr Val Leu Pro Arg Leu Glu Cys Ser Gly Met Ile Ser Ala His Cys 
                85                  90                  95      


Arg Leu Cys Leu Pro Gly Ser Ser Asn Ser Ser Cys Leu Ser Ile Pro 
            100                 105                 110         


Ser Ser Trp Asp Tyr Arg His Ala Pro Leu Cys Leu Ala Asn Phe Cys 
        115                 120                 125             


Ile Phe Asn Arg Asp Gly Val Leu Pro Arg Trp Pro Gly 
    130                 135                 140     


<210>  4571
<211>  4787
<212>  DNA
<213>  Homosapiens

<400>  4571
aatggccatc ttctctcggt atcctcacat ggtagggaga aaagcagctc tagtgtctct     60

tataaaggaa gtaatgccac cataggggct ctattctcat gacctcatct aaacctaatt    120

ctctcctaaa ggccacgcct cccagtatcc tcaccttggg ggttagggct ttatcatatg    180

aatttttttt tttttttttt tttttttgag acagagtctc gctctgtctg tcacccaggc    240

tggagtgcag tggcacaatc tcggctctct acaagctccg cctcctgggt tcacgccatt    300

ctcctgcgtc agcctcctca gtagctggga ctaaggcgcc cgccactgcg cccggctaat    360

tttttgtatt ttcagtagag acggggtttt accatgttag ccaggatgat ctcgatctcc    420

tgacctcatg atccacccgc ctcggcctcc caaagtgctg ggattacagg catgagccac    480

cgcgccgggc ctatcatatg aattttgagg gaacacaaac atgcagtctg tagcagatgg    540

taataggctg acatattaca cttgttgatg taaatctgat aggtttcttt ctctccaagg    600

acagcttttt aaatatttaa cagtatcaat aatttttcag gttctgtgag aattttataa    660

tttataattt gcagacttaa tgtataatct attttgtcct aacaattaca aatatatttt    720

ttatttcaga ttgtatatat tcctaccaga tggagataat tacagcttta aaaattttta    780

ttttttcatt ttatttcaca cattgacatt aaatttttat ggacacataa taactgtaca    840

tatatatggg gtagaatgtg atgttttaat acatgtactc aatgtgtaat gatcaaatca    900

gggtaatttg cataatgatt tttctgtagg gagaaaattc aaaatctact cttctggcta    960

ttttcaaata tataatatgt tattgttaac tatactcatc ctactatgca ataggacacc   1020

agaacttatt cctgggttct acatccgtta aggcaaccaa ggattggaaa tattggaaaa   1080

aaaaattgcg tctgtactga acatgtacag acttttttct tgtccttatt ccttacacaa   1140

tatagtacaa taactatttg catgacattt acatcggata ttatgagtga tctagagttg   1200

atatgaagta tatgggagga tgtgcaaagg tgatgtgcaa atactatgtc attttatatc   1260

agggacttga gtatcctttg ttaccctcag gagatcctga aaccagtccc ccatggatac   1320

tgagggctga ctgtatagtc ctatcctcac ggaactttca ttctaatggg ggaagactga   1380

ctataaacaa aatatatgta ataggtggtg gtaagtaccg tggagaagta acaaacgggg   1440

caaagtgagt tatacagctc cattcttaga aaccttggag tacttttctt agtttatact   1500

tgtggtggtt tccttttgtc tcctttatta catgggactc tgacatgtgc ccatagctag   1560

ggtgacagta ggatctaccc gatagtaggg tggcagtagg atctacccaa aaagcgtcct   1620

gctgatacag gaccaaagca tcctgttgtt ctcgagccta taaaaagagc taatggtctt   1680

gcttctctta actgtggcct cctacactgt gttttggatg attggtgatg tcttggatat   1740

tctgtttctt tggaactttg aatatacaac actttactag ggaattagca atggaagcag   1800

agcaaagatg tacagaggaa acaatgcgta actctgatgg aattgaagtc atgaggcagc   1860

agagagctta aattacagct ttaaaaattt ttatttttta gagggaattt acttgggagt   1920

aacagcagta atagttaacg gagccagaat gcttgagtca tataattgca aagcagagtt   1980

gggagcaaca gatgctaaag agtagttgct gtagttcctc tttgggtcgt aggagcagtt   2040

gtcatattcc tatatagcta ctgcatgaag aagagttctt agtgaggcct gggtgaacag   2100

ctcttcttag tattctgtgt gaccccattt gaccttttaa caaatcccta agtaaataaa   2160

tagcccctca ggtaaactaa gtttttctct gctgtttttt tgcttgagag agctataact   2220

gtaatagact tatatttctg aacatttcag tgcttgccaa tatttggtaa tatttatgtt   2280

tcctatattt gtaatgaaca ttcttcttcc ggtacatttt ttgttaaatt attgtttgat   2340

ggataaaagt tcacccttta ttgtataaaa ttgactgaga ttaatttata cacattgaca   2400

atgggtaaat agaatttttc agattattaa aagctgaagg atgcccacgt aagcaaaaaa   2460

aaaaaagaaa aaaccaacaa aaataaaccc aaacccctca aacaatttcg aacacgaaac   2520

attcttctga tgccggcatc cctgcttgca ggtgtgaagg gggcaggaat cagcgaggtg   2580

tcctgggctg agtccccgga gtgggaagag gtggcaggaa ggggatctga ggaggagaac   2640

aggggtcctg gtggtctgtg cttcttccca gacacgggag ctgtagagga gacctctgca   2700

gcagatgcta ggggggccag taggcccagg cagtcttggg acttgggtct gtcctgctgt   2760

gcatccatag tgggtgcttt agaaacggga ggcccacccg aagtccctgt tgcaagtgag   2820

gacaaagtgt gggaaggccg tgagggtctg cagtccggga tggccttgtc ctcaacgtgc   2880

agtgcactgt tgatgcgctg gaatgccgtc tctttttcca ggtgcaggtc ttcagccgtg   2940

acccggtacc ccagctctaa gggaggtggc agcatcaaag gctcccctcg cctgcgtggc   3000

agcaggggaa tcttgcgtct acggggccta gagtcctggg atctggggga gccacccgtt   3060

ggggcgattg tctgccctgg tgctgtatct gccccctttt cacaccgtgt gtgacccgaa   3120

gagacagcct gaggcctgtc ctcactcact gtctttgagt aactgagggt cagctggcag   3180

cgggatgagg ctggccccct cctctgcttt agccccggca agcctcccgt ggagctgtag   3240

gagctggaga tggcatttcg tttggtgctc gagctcgtcc aggatgtctg ggatgtgtgg   3300

ttatatctga tttctgagct ctgggcgtgg aggtctgtct gcagaggccc gggcctgggc   3360

acaaagggag aggggcctcc attgtcccgc aggggccaaa atgcagaccg tgcatccccg   3420

gtgacctcgg ggaccgttct ctgatcatca ggattttctt ggactctggg gtccttgtcc   3480

tgctcaggca tccctgcccc gctctccttg agggccctca acactatctt ccctggacac   3540

aagtctgggg acagccgggt gttgtggacc ccaaaggggt gactacctgc tcctgggccc   3600

cacagagtcc ttgtgctcag tgtagtggct gagctggggg atgccctgga actcggagca   3660

cacagcactg gcttactgtg gtacctgtgc agtgaaattg aagacagaat caccaggatg   3720

gaacacaggt cttgcaggat cacggaaaac cttcttagag ttgtcttgac accactgatg   3780

tcgagtgtgc gggtgtttgt aggatggcct gccactcagt ccaggggcag gagcaacggg   3840

gagatcccac aagcaaagtg aactggggga tgggctgaag gggctccagg caactgagcc   3900

ctactcgcag gtcctcggcc ttggcccaaa caggaatgag gggcacagag tgcccgggta   3960

accgctcctg ggagcagtgg ggaactgtcg gatacttgaa ctctcaagag ctgggctctg   4020

agcgtcctcg tccagctgcc aacttggcca aaggctaagc cagcagattg ttctgttgcc   4080

gggcaacgcg acttctaaac ctgagggagt gggcatgtga gcacataatg gcaccagtga   4140

cagagcgacc ataatggatg aataagcgca gccaggtacc ggcgcaaggc acctgctggc   4200

aatggcagga ggcggacgtg gggggtcgtg cagtaggtac tggagggaga gacgtgggca   4260

caaaggtcgc gggaggaaca ggtgcccaca atggctgcat atttgcccgt ggatcactga   4320

agattcctgc tctcctgctg aggtggagac tgcagtgagc tgagatcgca ccattgcact   4380

ccagcctggg caacgagtgc aaaactcagt ctccagataa aaaaaagaaa aagaaaaaaa   4440

agaggccggg tgtggtggct tatgcctatg atcctagcac tttgggaggt cggggtggac   4500

ggatcacgag atcaggagtt ggaggccagc ctggccaaca tagtgaaagc ccgtctctag   4560

taaaaataca aaatttagtc agacatggtg ggcaggagag agcatgtgca ggggaacatc   4620

catttataaa accatcagac ctcatgagac ttattcacta ccatgagaac agcatggggg   4680

aaactgcctc catgattcag ttatctccac ctggccccac ccttgacaca tgggaattgt   4740

tacaattcaa gatgagattt gggtgcggac agagccaaac catataa                 4787


<210>  4572
<211>  194
<212>  PRT
<213>  Homosapiens

<400>  4572

Met Pro Ala Ser Leu Leu Ala Gly Val Lys Gly Ala Gly Ile Ser Glu 
1               5                   10                  15      


Val Ser Trp Ala Glu Ser Pro Glu Trp Glu Glu Val Ala Gly Arg Gly 
            20                  25                  30          


Ser Glu Glu Glu Asn Arg Gly Pro Gly Gly Leu Cys Phe Phe Pro Asp 
        35                  40                  45              


Thr Gly Ala Val Glu Glu Thr Ser Ala Ala Asp Ala Arg Gly Ala Ser 
    50                  55                  60                  


Arg Pro Arg Gln Ser Trp Asp Leu Gly Leu Ser Cys Cys Ala Ser Ile 
65                  70                  75                  80  


Val Gly Ala Leu Glu Thr Gly Gly Pro Pro Glu Val Pro Val Ala Ser 
                85                  90                  95      


Glu Asp Lys Val Trp Glu Gly Arg Glu Gly Leu Gln Ser Gly Met Ala 
            100                 105                 110         


Leu Ser Ser Thr Cys Ser Ala Leu Leu Met Arg Trp Asn Ala Val Ser 
        115                 120                 125             


Phe Ser Arg Cys Arg Ser Ser Ala Val Thr Arg Tyr Pro Ser Ser Lys 
    130                 135                 140                 


Gly Gly Gly Ser Ile Lys Gly Ser Pro Arg Leu Arg Gly Ser Arg Gly 
145                 150                 155                 160 


Ile Leu Arg Leu Arg Gly Leu Glu Ser Trp Asp Leu Gly Glu Pro Pro 
                165                 170                 175     


Val Gly Ala Ile Val Cys Pro Gly Ala Val Ser Ala Pro Phe Ser His 
            180                 185                 190         


Arg Val 
        


<210>  4573
<211>  4871
<212>  DNA
<213>  Homosapiens

<400>  4573
gccaccgcgc cgggcctatc atatgaattt tgagggaaca caaacatgca gtctgtagca     60

gatggtaata ggctgacata ttacacttgt tgatgtaaat ctgataggtt tctttctctc    120

caaggacagc tttttaaata tttaacagta tcaataattt ttcaggttct gtgagaattt    180

tataatttat aatttgcaga cttaatgtat aatctatttt gtcctaacaa ttacaaatat    240

attttttatt tcagattgta tatattccta ccagatggag ataattacag ctttaaaaat    300

ttttattttt tcattttatt tcacacattg acattaaatt tttatggaca cataataact    360

gtacatatat atggggtaga atgtgatgtt ttaatacatg tactcaatgt gtaatgatca    420

aatcagggta atttgcataa tgatttttct gtagggagaa aattcaaaat ctactcttct    480

ggctattttc aaatatataa tatgttattg ttaactatac tcatcctact atgcaatagg    540

acaccagaac ttattcctgg gttctacatc cgttaaggca accaaggatt ggaaatattg    600

gaaaaaaaaa ttgcgtctgt actgaacatg tacagacttt tttcttgtcc ttattcctta    660

cacaatatag tacaataact atttgcatga catttacatc ggatattatg agtgatctag    720

agttgatatg aagtatatgg gaggatgtgc aaaggtgatg tgcaaatact atgtcatttt    780

atatcaggga cttgagtatc ctttgttacc ctcaggagat cctgaaacca gtcccccatg    840

gatactgagg gctgactgta tagtcctatc ctcacggaac tttcattcta atgggggaag    900

actgactata aacaaaatat atgtaatagg tggtggtaag taccgtggag aagtaacaaa    960

cggggcaaag tgagttatac agctccattc ttagaaacct tggagtactt ttcttagttt   1020

atacttgtgg tggtttcctt ttgtctcctt tattacatgg gactctgaca tgtgcccata   1080

gctagggtga cagtaggatc tacccgatag tagggtggca gtaggatcta cccaaaaagc   1140

gtcctgctga tacaggacca aagcatcctg ttgttctcga gcctataaaa agagctaatg   1200

gtcttgcttc tcttaactgt ggcctcctac actgtgtttt ggatgattgg tgatgtcttg   1260

gatattctgt ttctttggaa ctttgaatat acaacacttt actagggaat tagcaatgga   1320

agcagagcaa agatgtacag aggaaacaat gcgtaactct gatggaattg aagtcatgag   1380

gcagcagaga gcttaaatta cagctttaaa aatttttatt ttttagaggg aatttacttg   1440

ggagtaacag cagtaatagt taacggagcc agaatgcttg agtcatataa ttgcaaagca   1500

gagttgggag caacagatgc taaagagtag ttgctgtagt tcctctttgg gtcgtaggag   1560

cagttgtcat attcctatat agctactgca tgaagaagag ttcttagtga ggcctgggtg   1620

aacagctctt cttagtattc tgtgtgaccc catttgacct tttaacaaat ccctaagtaa   1680

ataaatagcc cctcaggtaa actaagtttt tctctgctgt ttttttgctt gagagagcta   1740

taactgtaat agacttatat ttctgaacat ttcagtgctt gccaatattt ggtaatattt   1800

atgtttccta tatttgtaat gaacattctt cttccggtac attttttgtt aaattattgt   1860

ttgatggata aaagttcacc ctttattgta taaaattgac tgagattaat ttatacacat   1920

tgacaatggg taaatagaat ttttcagatt attaaaagct gaaggatgcc cacgtaagca   1980

aaaaaaaaaa agaaaaaacc aacaaaaata aacccaaacc cctcaaacaa tttcgaacac   2040

gaaacattct tctgatgccg gcatccctgc ttgcaggtgt gaagggggca ggaatcagcg   2100

aggtgtcctg ggctgagtcc ccggagtggg aagaggtggc aggaagggga tctgaggagg   2160

agaacagggg tcctggtggt ctgtgcttct tcccagacac gggagctgta gaggagacct   2220

ctgcagcaga tgctaggggg gccagtaggc ccaggcagtc ttgggacttg ggtctgtcct   2280

gctgtgcatc catagtgggt gctttagaaa cgggaggccc acccgaagtc cctgttgcaa   2340

gtgaggacaa agtgtgggaa ggccgtgagg gtctgcagtc cgggatggcc ttgtcctcaa   2400

cgtgcagtgc actgttgatg cgctggaatg ccgtctcttt ttccaggtgc aggtcttcag   2460

ccgtgacccg gtaccccagc tctaagggag gtggcagcat caaaggctcc cctcgcctgc   2520

gtggcagcag gggaatcttg cgtctacggg gcctagagtc ctgggatctg ggggagccac   2580

ccgttggggc gattgtctgc cctggtgctg tatctgcccc cttttcacac cgtgtgtgac   2640

ccgaagagac agcctgaggc ctgtcctcac tcactgtctt tgagtaactg agggtcagct   2700

ggcagcggga tgaggctggc cccctcctct gctttagccc cggcaagcct cccgtggagc   2760

tgtaggagct ggagatggca tttcgtttgg tgctcgagct cgtccaggat gtctgggatg   2820

tgtggttata tctgatttct gagctctggg cgtggaggtc tgtctgcaga ggcccgggcc   2880

tgggcacaaa gggagagggg cctccattgt cccgcagggg ccaaaatgca gaccgtgcat   2940

ccccggtgac ctcggggacc gttctctgat catcaggatt ttcttggact ctggggtcct   3000

tgtcctgctc aggcatccct gccccgctct ccttgagggc cctcaacact atcttccctg   3060

gacacaagtc tggggacagc cgggtgttgt ggaccccaaa ggggtgacta cctgctcctg   3120

ggccccacag agtccttgtg ctcagtgtag tggctgagct gggggatgcc ctggaactcg   3180

gagcacacag cactggctta ctgtggtacc tgtgcagtga aattgaagac agaatcacca   3240

ggatggaaca caggtcttgc aggatcacgg aaaaccttct tagagttgtc ttgacaccac   3300

tgatgtcgag tgtgcgggtg tttgtaggat ggcctgccac tcagtccagg ggcaggagca   3360

acggggagat cccacaagca aagtgaactg ggggatgggc tgaaggggct ccaggcaact   3420

gagccctact cgcaggtcct cggccttggc ccaaacagga atgaggggca cagagtgccc   3480

gggtaaccgc tcctgggagc agtggggaac tgtcggatac ttgaactctc aagagctggg   3540

ctctgagcgt cctcgtccag ctgccaactt ggccaaaggc taagccagca gattgttctg   3600

ttgccgggca acgcgacttc taaacctgag ggagtgggca tgtgagcaca taatggcacc   3660

agtgacagag cgaccataat ggatgaataa gcgcagccag ggctggtgaa ttaccagatc   3720

tccgtcaagt gcagtaacca gttcaagttg gaagtgtgtc ttttgaatgc agaaaacaaa   3780

gtcgtggaca accaggctgg gacccagggc cagctgaagg tgctgggtgc caacctctgg   3840

tggccgtacc tgatgcacga acaccccgcc tacctgtact cgtgggagga tggtgattgc   3900

tcacaccaaa gccttggacc cctcccagcc tgtgaccttt gtgaccaact ccacctacgc   3960

agcagacaag ggggctctgt atgtggatgt gatccgtgtg aacagctact actcttggta   4020

tcgcaactac gggcacctgg agttgattca gctgcagctg gccgcccagt ttgagaattg   4080

gtgtaagaca tcacaatccc attattcaga gcgcgtatgg agtggaaacg cttgtagggc   4140

ttcaccaggt aagcggtgtt gaactttctg cttgtgtatt ctctctgggc agagatgcca   4200

cttgcctccc ccaccatgcc atctctgaag aatattacag accattttgg agcatggtga   4260

ataagaaatt ttcaccttag gagttcagtt gaatagtcat ttttatattt gtgactgcaa   4320

gtcactctta ggggctgtac ttccttagta ctggtagcat tattatccaa tggactttta   4380

tagctttcat taggttttct tttgtttttg ttctttaaag aacgttttac ttatcttagt   4440

atttcatttt tcatctatat tatgaggcag taagagtctt ctgtttttcc aaagttgaga   4500

ctgctttata tttatttcgt attgtctaca gctgtagtgt tcaatacatt agccactagc   4560

cacatgtggt tatttaaata agataaaata aaaattggcc gggcgtggtg gctcacgccg   4620

gtaatcccag cactttggga ggccgaggcg ggcagatcat taggtcagga gatcgagacc   4680

atccttacta agacggtgaa cccccatctc tattaaaaat acaaaaaatt agccgggcgt   4740

ggtggcgggc gcctgcagtc ccagctactc aggaggctga ggcaggagaa tggcgtgaac   4800

ctgggaggca gagtttgcag tgagccgaga tggcgccact gcactccagc ctgggggaca   4860

gagcgagact c                                                        4871


<210>  4574
<211>  194
<212>  PRT
<213>  Homosapiens

<400>  4574

Met Pro Ala Ser Leu Leu Ala Gly Val Lys Gly Ala Gly Ile Ser Glu 
1               5                   10                  15      


Val Ser Trp Ala Glu Ser Pro Glu Trp Glu Glu Val Ala Gly Arg Gly 
            20                  25                  30          


Ser Glu Glu Glu Asn Arg Gly Pro Gly Gly Leu Cys Phe Phe Pro Asp 
        35                  40                  45              


Thr Gly Ala Val Glu Glu Thr Ser Ala Ala Asp Ala Arg Gly Ala Ser 
    50                  55                  60                  


Arg Pro Arg Gln Ser Trp Asp Leu Gly Leu Ser Cys Cys Ala Ser Ile 
65                  70                  75                  80  


Val Gly Ala Leu Glu Thr Gly Gly Pro Pro Glu Val Pro Val Ala Ser 
                85                  90                  95      


Glu Asp Lys Val Trp Glu Gly Arg Glu Gly Leu Gln Ser Gly Met Ala 
            100                 105                 110         


Leu Ser Ser Thr Cys Ser Ala Leu Leu Met Arg Trp Asn Ala Val Ser 
        115                 120                 125             


Phe Ser Arg Cys Arg Ser Ser Ala Val Thr Arg Tyr Pro Ser Ser Lys 
    130                 135                 140                 


Gly Gly Gly Ser Ile Lys Gly Ser Pro Arg Leu Arg Gly Ser Arg Gly 
145                 150                 155                 160 


Ile Leu Arg Leu Arg Gly Leu Glu Ser Trp Asp Leu Gly Glu Pro Pro 
                165                 170                 175     


Val Gly Ala Ile Val Cys Pro Gly Ala Val Ser Ala Pro Phe Ser His 
            180                 185                 190         


Arg Val 
        


<210>  4575
<211>  3489
<212>  DNA
<213>  Homosapiens

<400>  4575
gagtatcctt tgttaccctc aggagatcct gaaaccagtc ccccatggat actgagggct     60

gactgtatag tcctatcctc acggaacttt cattctaatg ggggaagact gactataaac    120

aaaatatatg taataggtgg tggtaagtac cgtggagaag taacaaacgg ggcaaagtga    180

gttatacagc tccattctta gaaaccttgg agtacttttc ttagtttata cttgtggtgg    240

tttccttttg tctcctttat tacatgggac tctgacatgt gcccatagct agggtgacag    300

taggatctac ccgatacgtc ctgctgatac aggaccaaag catcctgttg ttctcgagcc    360

tataaaaaga gctaatggtc ttgcttctct taactgtggc ctcctacact gtgttttgga    420

tgattggtga tgtcttggat attctgtttc tttggaactt tgaatataca acactttact    480

agggaattag caatggaagc agagcaaaga tgtacagagg aaacaatgcg taactctgat    540

ggaattgaag tcatgaggca gcagagagct taaattacag ctttaaaaat ttttattttt    600

tagagggaat ttacttggga gtaacagcag taatagttaa cggagccaga atgcttgagt    660

catataattg caaagcagag ttgggagcaa cagatgctaa agagtagttg ctgtagttcc    720

tctttgggtc gtaggagcag ttgtcatatt cctatatagc tactgcatga agaagagttc    780

ttagtgaggc ctgggtgaac agctcttctt agtattctgt gtgaccccat ttgacctttt    840

aacaaatccc taagtaaata aatagcccct caggtaaact aagtttttct ctgctgtttt    900

tttgcttgag agagctataa ctgtaataga cttatatttc tgaacatttc agtgcttgcc    960

aatatttggt aatatttatg tttcctatat ttgtaatgaa cattcttctt ccggtacatt   1020

ttttgttaaa ttattgtttg atggataaaa gttcaccctt tattgtataa aattgactga   1080

gattaattta tacacattga caatgggtaa atagaatttt tcagattatt aaaagctgaa   1140

ggatgcccac gtaagcaaaa aaaaaaaaga aaaaaccaac aaaaataaac ccaaacccct   1200

caaacaattt cgaacacgaa acattcttct gatgccggca tccctgcttg caggtgtgaa   1260

gggggcagga atcagcgagg tgtcctgggc tgagtccccg gagtgggaag aggtggcagg   1320

aaggggatct gaggaggaga acaggggtcc tggtggtctg tgcttcttcc cagacacggg   1380

agctgtagag gagacctctg cagcagatgc taggggggcc agtaggccca ggcagtcttg   1440

ggacttgggt ctgtcctgct gtgcatccat agtgggtgct ttagaaacgg gaggcccacc   1500

cgaagtccct gttgcaagtg aggacaaagt gtgggaaggc cgtgagggtc tgcagtccgg   1560

gatggccttg tcctcaacgt gcagtgcact gttgatgcgc tggaatgccg tctctttttc   1620

caggtgcagg tcttcagccg tgacccggta ccccagctct aagggaggtg gcagcatcaa   1680

aggctcccct cgcctgcgtg gcagcagggg aatcttgcgt ctacggggcc tagagtcctg   1740

ggatctgggg gagccacccg ttggggcgat tgtctgccct ggtgctgtat ctgccccctt   1800

ttcacaccgt gtgtgacccg aagagacagc ctgaggcctg tcctcactca ctgtctttga   1860

gtaactgagg gtcagctggc agcgggatga ggctggcccc ctcctctgct ttagccccgg   1920

caagcctccc gtggagctgt aggagctgga gatggcattt cgtttggtgc tcgagctcgt   1980

ccaggatgtc tgggatgtgt ggttatatct gatttctgag ctctgggcgt ggaggtctgt   2040

ctgcagaggc ccgggcctgg gcacaaaggg agaggggcct ccattgtccc gcaggggcca   2100

aaatgcagac cgtgcatccc cggtgacctc ggggaccgtt ctctgatcat caggattttc   2160

ttggactctg gggtccttgt cctgctcagg catccctgcc ccgctctcct tgagggccct   2220

caacactatc ttccctggac acaagtctgg ggacagccgg gtgttgtgga ccccaaaggg   2280

gtgactacct gctcctgggc cccacagagt ccttgtgctc agtgtagtgg ctgagctggg   2340

ggatgccctg gaactcggag cacacagcac tggcttactg tggtacctgt gcagtgaaat   2400

tgaagacaga atcaccagga tggaacacag gtcttgcagg atcacggaaa accttcttag   2460

agttgtcttg acaccactga tgtcgagtgt gcgggtgttt gtaggatggc ctgccactca   2520

gtccaggggc aggagcaacg gggagatccc acaagcaaag tgaactgggg gatgggctga   2580

aggggctcca ggcaactgag ccctactcgc aggtcctcgg ccttggccca aacaggaatg   2640

aggggcacag agtgcccggg taaccgctcc tgggagcagt ggggaactgt cggatacttg   2700

aactctcaag agctgggctc tgagcgtcct cgtccagctg ccaacttggc caaaggctaa   2760

gccagcagat tgttctgttg ccgggcaacg cgacttctaa acctgaggga gtgggcatgt   2820

gagcacataa tggcaccagt gacagagcga ccataatgga tgaataagcg cagccaggta   2880

ccggcgcaag gcacctgctg gcaatggcag gaggcggacg tggggggtcg tgcagtaggt   2940

actggaggga gagacgtggg cacaaaggtc gcgggaggaa caggtgccca caatggctgc   3000

atatttgccc gtggatcact gaagattcct gctctcctgc tgaggtggag actgcagtga   3060

gctgagatcg caccattgca ctccagcctg ggcaacgagt gcaaaactca gtctccagat   3120

aaaaaaaaga aaaagaaaaa aaagaggccg ggtgtggtgg cttatgccta tgatcctagc   3180

actttgggag gtcggggtgg acggatcacg agatcaggag ttggaggcca gcctggccaa   3240

catagtgaaa gcccgtctct agtaaaaata caaaatttag tcagacatgg tgggcaggag   3300

agagcatgtg caggggaaca tccatttata aaaccatcag acctcatgag acttattcac   3360

taccatgaga acagcatggg ggaaactgcc tccatgattc agttatctcc acctggcccc   3420

acccttgaca catgggaatt gttacaattc aagatgagat ttgggtgcgg acagagccaa   3480

accatataa                                                           3489


<210>  4576
<211>  194
<212>  PRT
<213>  Homosapiens

<400>  4576

Met Pro Ala Ser Leu Leu Ala Gly Val Lys Gly Ala Gly Ile Ser Glu 
1               5                   10                  15      


Val Ser Trp Ala Glu Ser Pro Glu Trp Glu Glu Val Ala Gly Arg Gly 
            20                  25                  30          


Ser Glu Glu Glu Asn Arg Gly Pro Gly Gly Leu Cys Phe Phe Pro Asp 
        35                  40                  45              


Thr Gly Ala Val Glu Glu Thr Ser Ala Ala Asp Ala Arg Gly Ala Ser 
    50                  55                  60                  


Arg Pro Arg Gln Ser Trp Asp Leu Gly Leu Ser Cys Cys Ala Ser Ile 
65                  70                  75                  80  


Val Gly Ala Leu Glu Thr Gly Gly Pro Pro Glu Val Pro Val Ala Ser 
                85                  90                  95      


Glu Asp Lys Val Trp Glu Gly Arg Glu Gly Leu Gln Ser Gly Met Ala 
            100                 105                 110         


Leu Ser Ser Thr Cys Ser Ala Leu Leu Met Arg Trp Asn Ala Val Ser 
        115                 120                 125             


Phe Ser Arg Cys Arg Ser Ser Ala Val Thr Arg Tyr Pro Ser Ser Lys 
    130                 135                 140                 


Gly Gly Gly Ser Ile Lys Gly Ser Pro Arg Leu Arg Gly Ser Arg Gly 
145                 150                 155                 160 


Ile Leu Arg Leu Arg Gly Leu Glu Ser Trp Asp Leu Gly Glu Pro Pro 
                165                 170                 175     


Val Gly Ala Ile Val Cys Pro Gly Ala Val Ser Ala Pro Phe Ser His 
            180                 185                 190         


Arg Val 
        


<210>  4577
<211>  1378
<212>  DNA
<213>  Homosapiens

<400>  4577
tgctacgcgg cacccggtcc cgtcaaccgc ccaacggctg aggagtgcgg cagcgcgcca     60

gagactggcg ggcagctccg cccgcggccg ggatgcacta ggcaaagcca gctgggctcc    120

tgagtccggt gggtacttgg agaacttact acgtctagct ggaggattgt aaatgcacca    180

atcagcatgc tgtgtctagc tcaagaactc aagctccatg aggagatgtt tcattgtcga    240

gagcagtcat gatggcctgc actccacaca atgcaacaga gtgaaagagc aggttctgct    300

tctttggtgt agtcctgaag cttcctaaga aacttcacat caggtgatgg ataggagcaa    360

ccctgtaaaa ccagccttag actatttttc aaacagatgg tgattgctca caccaaagcc    420

ttggacccct cccagcctgt gacctttgtg accaactcca cctacgcagc agacaagggg    480

gctctgtatg tggatgtgat ccgtgtgaac agctactact cttggtatcg caactacggg    540

cacctggagt tgattcagct gcagctggcc gcccagtttg agaattggtg taagacatca    600

caatcccatt attcagagcg cgtatggagt ggaaacgctt gtagggcttc accaggtaag    660

cggtgttgaa ctttctgctt gtgtattctc tctgggcaga gatgccactt gcctccccca    720

ccatgccatc tctgaagaat attacagacc attttggagc atggtgaata agaaattttc    780

accttaggag ttcagttgaa tagtcatttt tatatttgtg actgcaagtc actcttaggg    840

gctgtacttc cttagtactg gtagcattat tatccaatgg acttttatag ctttcattag    900

gttttctttt gtttttgttc tttaaagaac gttttactta tcttagtatt tcatttttca    960

tctatattat gaggcagtaa gagtcttctg tttttccaaa gttgagactg ctttatattt   1020

atttcgtatt gtctacagct gtagtgttca atacattagc cactagccac atgtggttat   1080

ttaaataaga taaaataaaa attggccggg cgtggtggct cacgccggta atcccagcac   1140

tttgggaggc cgaggcgggc agatcattag gtcaggagat cgagaccatc cttactaaga   1200

cggtgaaccc ccatctctat taaaaataca aaaaattagc cgggcgtggt ggcgggcgcc   1260

tgcagtccca gctactcagg aggctgaggc aggagaatgg cgtgaacctg ggaggcagag   1320

tttgcagtga gccgagatgg cgccactgca ctccagcctg ggggacagag cgagactc     1378


<210>  4578
<211>  21
<212>  PRT
<213>  Homosapiens

<400>  4578

Met Leu Cys Leu Ala Gln Glu Leu Lys Leu His Glu Glu Met Phe His 
1               5                   10                  15      


Cys Arg Glu Gln Ser 
            20      


<210>  4579
<211>  301
<212>  DNA
<213>  Homosapiens

<400>  4579
aaagctccat tccgacttag acaagggaga gggcactgcg aaatacaccc tctcaggaga     60

tggcgctggc accgttttta ccattgatga aaccacaggg gacattcatg caataaggag    120

cctagataga gaagaaaaac ctttctacac tcttcgtgct caggctgtgg acatagaaac    180

cagaaagccc ctggagcctg aatcagaatt catcatcaaa gtgcaggata ttaatgataa    240

tgagccaaag ttttgggatg gaccttatgt tgctactgtc ccagaaatgt ctcctgtggg    300

t                                                                    301


<210>  4580
<211>  5196
<212>  DNA
<213>  Homosapiens

<400>  4580
atggtaatat tgtgggaact gagtgaaaat tcagaatgtg aatttcttcg gagtaagaaa     60

tcctcagagg aaattaccca gtatattcaa agctacaagg gatttgttga cataacggga    120

gaacattttg tgaattcctg ggtccagaga gaattaccta tggcatcagc ttattgcaat    180

gacagcatct ttgcttacga agaactacgg ctggactctt ttaaggactg gccccgggaa    240

tcagctgtgg gagttgcagc actggccaaa gcaggtcttt tctacacagg tataaaggac    300

atcgtccagt gcttttcctg tggagggtgt ttagagaaat ggcaggaagg tgatgaccca    360

ttagacgatc acaccagatg ttttcccaat tgtccatttc tccaaaatat gaagtcctct    420

gcggaagtga ctccagacct tcagagccgt ggtgaacttt gtgaattact ggaaaccaca    480

agtgaaagca atcttgaaga ttcaatagca gttggtccta tagtgccaga aatggcacag    540

ggtgaagccc agtggtttca agaggcaaag aatctgaatg agcagctgag agcagcttat    600

accagcgcca gtttccgcca catgtctttg cttgatatct cttccgatct ggccacggac    660

cacttgctgg gctgtgatct gtctattgct tcaaaacaca tcagcaaacc tgtgcaagaa    720

cctctggtgc tgcctgaggt ctttggcaac ttgaactctg tcatgtgtgt ggagggtgaa    780

gctggaagtg gaaagacggt cctcctgaag aaaatagctt ttctgtgggc atctggatgc    840

tgtcccctgt taaacaggtt ccagctggtt ttctacctct cccttagttc caccagacca    900

gacgaggggc tggccagtat catctgtgac cagctcctag agaaagaagg atctgttact    960

gaaatgtgca tgaggaacat tatccagcag ttaaagaatc aggtcttatt ccttttagat   1020

gactacaaag aaatatgttc aatccctcaa gtcataggaa aactgattca aaaaaaccac   1080

ttatcccgga cctgcctatt gattgctgtc cgtacaaaca gggccaggga catccgccga   1140

tacctagaga ccattctaga gatcaaagca tttccctttt ataatactgt ctgtatatta   1200

cggaagctct tttcacataa tatgactcgt ctgcgaaagt ttatggttta ctttggaaag   1260

aaccaaagtt tgcagaagat acagaaaact cctctctttg tggcggcgat ctgtgctcat   1320

tggtttcagt atccttttga cccatccttt gatgatgtgg ctgttttcaa gtcctatatg   1380

gaacgccttt ccttaaggaa caaagcgaca gctgaaattc tcaaagcaac tgtgtcctcc   1440

tgtggtgagc tggccttgaa agggtttttt tcatgttgct ttgagtttaa tgatgatgat   1500

ctcgcagaag caggggttga tgaagatgaa gatctaacca tgtgcttgat gagcaaattt   1560

acagcccaga gactaagacc attctaccgg tttttaagtc ctgccttcca agaatttctt   1620

gcggggatga ggctgattga actcctggat tcagataggc aggaacatca agatttggga   1680

ctgtatcatt tgaaacaaat caactcaccc atgatgactg taagcgccta caacaatttt   1740

ttgaactatg tctccagcct cccttcaaca aaagcagggc ccaaaattgt gtctcatttg   1800

ctccatttag tggataacaa agagtcattg gagaatatat ctgaaaatga tgactactta   1860

aagcaccagc cagaaatttc actgcagatg cagttactta ggggattgtg gcaaatttgt   1920

ccacaagctt acttttcaat ggtttcagaa catttactgg ttcttgccct gaaaactgct   1980

tatcaaagca acactgttgc tgcgtgttct ccatttgttt tgcaattcct tcaagggaga   2040

acactgactt tgggtgcgct taacttacag tactttttcg accacccaga aagcttgtca   2100

ttgttgagga gcatccactt cccaatacga ggaaataaga catcacccag agcacatttt   2160

tcagttctgg aaacatgttt tgacaaatca caggtgccaa ctatagatca ggactatgct   2220

tctgcctttg aacctatgaa tgaatgggag cgaaatttag ctgaaaaaga ggataatgta   2280

aagagctata tggatatgca gcgcagggca tcaccagacc ttagtactgg ctattggaaa   2340

ctttctccaa agcagtacaa gattccctgt ctagaagtcg atgtgaatga tattgatgtt   2400

gtaggccagg atatgcttga gattctaatg acagttttct cagcttcaca gcgcatcgaa   2460

ctccatttaa accacagcag aggctttata gaaagcatcc gcccagctct tgagctgtct   2520

aaggcctctg tcaccaagtg ctccataagc aagttggaac tcagcgcagc cgaacaggaa   2580

ctgcttctca ccctgccttc cctggaatct cttgaagtct cagggacaat ccagtcacaa   2640

gaccaaatct ttcctaatct ggataagttc ctgtgcctga aagaactgtc tgtggatctg   2700

gagggcaata taaatgtttt ttcagtcatt cctgaagaat ttccaaactt ccaccatatg   2760

gagaaattat tgatccaaat ttcagctgag tatgatcctt ccaaactagt aaaattaatt   2820

caaaattctc caaaccttca tgttttccat ctgaagtgta acttcttttc ggattttggg   2880

tctctcatga ctatgcttgt ttcctgtaag aaactcacag aaattaagtt ttcggattca   2940

ttttttcaag ccgtcccatt tgttgccagt ttgccaaatt ttatttctct gaagatatta   3000

aatcttgaag gccagcaatt tcctgatgag gaaacatcag aaaaatttgc ctacatttta   3060

ggttctctta gtaacctgga agaattgatc cttcctactg gggatggaat ttatcgagtg   3120

gccaaactga tcatccagca gtgtcagcag cttcattgtc tccgagtcct ctcatttttc   3180

aagactttga atgatgacag cgtggtggaa attgccaaag tagcaatcag tggaggtttc   3240

cagaaacttg agaacctaaa gctttcaatc aatcacaaga ttacagagga aggatacaga   3300

aatttctttc aagcactgga caacatgcca aacttgcagg agttggacat ctccaggcat   3360

ttcacagagt gtatcaaagc tcaggccaca acagtcaagt ctttgagtca atgtgtgtta   3420

cgactaccaa ggctcattag actgaacatg ttaagttggc tcttggatgc agatgatatt   3480

gcattgctta atgtcatgaa agaaagacat cctcaatcta agtacttaac tattctccag   3540

aaatggatac tgccgttctc tccaatcatt cagaaataaa agattcagct aaaaactgct   3600

gaatcaataa tttgtcttgg ggcatattga ggatgtaaaa aaagttgttg attaatgcta   3660

aaaaccaaat tatccaaaat tattttatta aatattgcat acaaaagaaa atgtgtaagg   3720

cttgctaaaa aacaaaacaa aacaaaacac agtcctgcat actcaccacc aagctcaaga   3780

aataaatcat caccaatacc tttgaggtcc ctgagtaatc caccccagct aaaggcaaac   3840

ccttcaatca ggtttataca gcaaaccctc cattgtccat ggtcaacagg gaaggggttg   3900

gggacaggtc tgccaatcta tctaaaagcc acaatatgga agaagtattc aatttatata   3960

ataaatggct aacttaacgg ttgaatcact ttcatacatg gatgaaacgg gtttaacaca   4020

ggatccacat gaatcttctg tgggccaaga gatgttcctt aatccttgta gaacctgttt   4080

tctatattga actagctttg gtacagtaga gttaacttac tttccattta tccactgcca   4140

atataaagag gaaacagggg ttagggaaaa atgacttcat tccagaggct tctcagagtt   4200

caacatatgc tataatttag aattttctta tgaatccact ctacttgggt agaaaatatt   4260

ttatctctag tgattgcata ttatttccat atcatagtat ttcatagtat tatatttgat   4320

atgagtgtct atatcaatgt cagtgtccag aatttcgttc ctaccagtta agtagttttc   4380

tgaacggcca gaagaccatt cgaaattcat gatactacta taagttggta aacaaccata   4440

cttttatcct catttttatt ctcactaaga aaaaagtcaa ctcccctccc cttgcccaag   4500

tatgaaatat agggacagta tgtatggtgt ggtctcattt gtttagaaaa ccacttatga   4560

ctgggtgcgg tggctcacac ctgtaatccc agcactttgg gaggctgagg cgggcgaatc   4620

atttgaggtg aggaattcga gaccagcctg gccagcatgg tgaaacccca tctctactaa   4680

aaatacaaaa attagccagg tgtggtggca catgcctgta gtcccagcca ctagggcggc   4740

tgagacgcaa gacttgcttg aacccgggag gcagaggttg cagtgagcca agatggcgcc   4800

actgcattcc agcctgggca acagagcaag accctgtctg tctcaaaaca aaaaacaaaa   4860

ccacttatat tgctagctac attaagaatt tctgaatatg ttactgagct tgcttgtggt   4920

aaccatttat aatatcagaa agtatatgta caccaaaaca tgttgaacat ccatgttgta   4980

caactgaaat ataaataatt ttgtcaatta tacctaaata aaactggaaa aaaatttctg   5040

gaagtttata tctaaaaatg ttaatagtgc gtacctctag gaagtgggcc tggaagccat   5100

tcttactttt cagtctctcc cattctgtac tgttttttgt tttactttcg tgcctgcatt   5160

atttttctat ttaaaacaaa aataaatcta gtttag                             5196


<210>  4581
<211>  1192
<212>  PRT
<213>  Homosapiens

<400>  4581

Met Val Ile Leu Trp Glu Leu Ser Glu Asn Ser Glu Cys Glu Phe Leu 
1               5                   10                  15      


Arg Ser Lys Lys Ser Ser Glu Glu Ile Thr Gln Tyr Ile Gln Ser Tyr 
            20                  25                  30          


Lys Gly Phe Val Asp Ile Thr Gly Glu His Phe Val Asn Ser Trp Val 
        35                  40                  45              


Gln Arg Glu Leu Pro Met Ala Ser Ala Tyr Cys Asn Asp Ser Ile Phe 
    50                  55                  60                  


Ala Tyr Glu Glu Leu Arg Leu Asp Ser Phe Lys Asp Trp Pro Arg Glu 
65                  70                  75                  80  


Ser Ala Val Gly Val Ala Ala Leu Ala Lys Ala Gly Leu Phe Tyr Thr 
                85                  90                  95      


Gly Ile Lys Asp Ile Val Gln Cys Phe Ser Cys Gly Gly Cys Leu Glu 
            100                 105                 110         


Lys Trp Gln Glu Gly Asp Asp Pro Leu Asp Asp His Thr Arg Cys Phe 
        115                 120                 125             


Pro Asn Cys Pro Phe Leu Gln Asn Met Lys Ser Ser Ala Glu Val Thr 
    130                 135                 140                 


Pro Asp Leu Gln Ser Arg Gly Glu Leu Cys Glu Leu Leu Glu Thr Thr 
145                 150                 155                 160 


Ser Glu Ser Asn Leu Glu Asp Ser Ile Ala Val Gly Pro Ile Val Pro 
                165                 170                 175     


Glu Met Ala Gln Gly Glu Ala Gln Trp Phe Gln Glu Ala Lys Asn Leu 
            180                 185                 190         


Asn Glu Gln Leu Arg Ala Ala Tyr Thr Ser Ala Ser Phe Arg His Met 
        195                 200                 205             


Ser Leu Leu Asp Ile Ser Ser Asp Leu Ala Thr Asp His Leu Leu Gly 
    210                 215                 220                 


Cys Asp Leu Ser Ile Ala Ser Lys His Ile Ser Lys Pro Val Gln Glu 
225                 230                 235                 240 


Pro Leu Val Leu Pro Glu Val Phe Gly Asn Leu Asn Ser Val Met Cys 
                245                 250                 255     


Val Glu Gly Glu Ala Gly Ser Gly Lys Thr Val Leu Leu Lys Lys Ile 
            260                 265                 270         


Ala Phe Leu Trp Ala Ser Gly Cys Cys Pro Leu Leu Asn Arg Phe Gln 
        275                 280                 285             


Leu Val Phe Tyr Leu Ser Leu Ser Ser Thr Arg Pro Asp Glu Gly Leu 
    290                 295                 300                 


Ala Ser Ile Ile Cys Asp Gln Leu Leu Glu Lys Glu Gly Ser Val Thr 
305                 310                 315                 320 


Glu Met Cys Met Arg Asn Ile Ile Gln Gln Leu Lys Asn Gln Val Leu 
                325                 330                 335     


Phe Leu Leu Asp Asp Tyr Lys Glu Ile Cys Ser Ile Pro Gln Val Ile 
            340                 345                 350         


Gly Lys Leu Ile Gln Lys Asn His Leu Ser Arg Thr Cys Leu Leu Ile 
        355                 360                 365             


Ala Val Arg Thr Asn Arg Ala Arg Asp Ile Arg Arg Tyr Leu Glu Thr 
    370                 375                 380                 


Ile Leu Glu Ile Lys Ala Phe Pro Phe Tyr Asn Thr Val Cys Ile Leu 
385                 390                 395                 400 


Arg Lys Leu Phe Ser His Asn Met Thr Arg Leu Arg Lys Phe Met Val 
                405                 410                 415     


Tyr Phe Gly Lys Asn Gln Ser Leu Gln Lys Ile Gln Lys Thr Pro Leu 
            420                 425                 430         


Phe Val Ala Ala Ile Cys Ala His Trp Phe Gln Tyr Pro Phe Asp Pro 
        435                 440                 445             


Ser Phe Asp Asp Val Ala Val Phe Lys Ser Tyr Met Glu Arg Leu Ser 
    450                 455                 460                 


Leu Arg Asn Lys Ala Thr Ala Glu Ile Leu Lys Ala Thr Val Ser Ser 
465                 470                 475                 480 


Cys Gly Glu Leu Ala Leu Lys Gly Phe Phe Ser Cys Cys Phe Glu Phe 
                485                 490                 495     


Asn Asp Asp Asp Leu Ala Glu Ala Gly Val Asp Glu Asp Glu Asp Leu 
            500                 505                 510         


Thr Met Cys Leu Met Ser Lys Phe Thr Ala Gln Arg Leu Arg Pro Phe 
        515                 520                 525             


Tyr Arg Phe Leu Ser Pro Ala Phe Gln Glu Phe Leu Ala Gly Met Arg 
    530                 535                 540                 


Leu Ile Glu Leu Leu Asp Ser Asp Arg Gln Glu His Gln Asp Leu Gly 
545                 550                 555                 560 


Leu Tyr His Leu Lys Gln Ile Asn Ser Pro Met Met Thr Val Ser Ala 
                565                 570                 575     


Tyr Asn Asn Phe Leu Asn Tyr Val Ser Ser Leu Pro Ser Thr Lys Ala 
            580                 585                 590         


Gly Pro Lys Ile Val Ser His Leu Leu His Leu Val Asp Asn Lys Glu 
        595                 600                 605             


Ser Leu Glu Asn Ile Ser Glu Asn Asp Asp Tyr Leu Lys His Gln Pro 
    610                 615                 620                 


Glu Ile Ser Leu Gln Met Gln Leu Leu Arg Gly Leu Trp Gln Ile Cys 
625                 630                 635                 640 


Pro Gln Ala Tyr Phe Ser Met Val Ser Glu His Leu Leu Val Leu Ala 
                645                 650                 655     


Leu Lys Thr Ala Tyr Gln Ser Asn Thr Val Ala Ala Cys Ser Pro Phe 
            660                 665                 670         


Val Leu Gln Phe Leu Gln Gly Arg Thr Leu Thr Leu Gly Ala Leu Asn 
        675                 680                 685             


Leu Gln Tyr Phe Phe Asp His Pro Glu Ser Leu Ser Leu Leu Arg Ser 
    690                 695                 700                 


Ile His Phe Pro Ile Arg Gly Asn Lys Thr Ser Pro Arg Ala His Phe 
705                 710                 715                 720 


Ser Val Leu Glu Thr Cys Phe Asp Lys Ser Gln Val Pro Thr Ile Asp 
                725                 730                 735     


Gln Asp Tyr Ala Ser Ala Phe Glu Pro Met Asn Glu Trp Glu Arg Asn 
            740                 745                 750         


Leu Ala Glu Lys Glu Asp Asn Val Lys Ser Tyr Met Asp Met Gln Arg 
        755                 760                 765             


Arg Ala Ser Pro Asp Leu Ser Thr Gly Tyr Trp Lys Leu Ser Pro Lys 
    770                 775                 780                 


Gln Tyr Lys Ile Pro Cys Leu Glu Val Asp Val Asn Asp Ile Asp Val 
785                 790                 795                 800 


Val Gly Gln Asp Met Leu Glu Ile Leu Met Thr Val Phe Ser Ala Ser 
                805                 810                 815     


Gln Arg Ile Glu Leu His Leu Asn His Ser Arg Gly Phe Ile Glu Ser 
            820                 825                 830         


Ile Arg Pro Ala Leu Glu Leu Ser Lys Ala Ser Val Thr Lys Cys Ser 
        835                 840                 845             


Ile Ser Lys Leu Glu Leu Ser Ala Ala Glu Gln Glu Leu Leu Leu Thr 
    850                 855                 860                 


Leu Pro Ser Leu Glu Ser Leu Glu Val Ser Gly Thr Ile Gln Ser Gln 
865                 870                 875                 880 


Asp Gln Ile Phe Pro Asn Leu Asp Lys Phe Leu Cys Leu Lys Glu Leu 
                885                 890                 895     


Ser Val Asp Leu Glu Gly Asn Ile Asn Val Phe Ser Val Ile Pro Glu 
            900                 905                 910         


Glu Phe Pro Asn Phe His His Met Glu Lys Leu Leu Ile Gln Ile Ser 
        915                 920                 925             


Ala Glu Tyr Asp Pro Ser Lys Leu Val Lys Leu Ile Gln Asn Ser Pro 
    930                 935                 940                 


Asn Leu His Val Phe His Leu Lys Cys Asn Phe Phe Ser Asp Phe Gly 
945                 950                 955                 960 


Ser Leu Met Thr Met Leu Val Ser Cys Lys Lys Leu Thr Glu Ile Lys 
                965                 970                 975     


Phe Ser Asp Ser Phe Phe Gln Ala Val Pro Phe Val Ala Ser Leu Pro 
            980                 985                 990         


Asn Phe Ile Ser Leu Lys Ile Leu  Asn Leu Glu Gly Gln  Gln Phe Pro 
        995                 1000                 1005             


Asp Glu  Glu Thr Ser Glu Lys  Phe Ala Tyr Ile Leu  Gly Ser Leu 
    1010                 1015                 1020             


Ser Asn  Leu Glu Glu Leu Ile  Leu Pro Thr Gly Asp  Gly Ile Tyr 
    1025                 1030                 1035             


Arg Val  Ala Lys Leu Ile Ile  Gln Gln Cys Gln Gln  Leu His Cys 
    1040                 1045                 1050             


Leu Arg  Val Leu Ser Phe Phe  Lys Thr Leu Asn Asp  Asp Ser Val 
    1055                 1060                 1065             


Val Glu  Ile Ala Lys Val Ala  Ile Ser Gly Gly Phe  Gln Lys Leu 
    1070                 1075                 1080             


Glu Asn  Leu Lys Leu Ser Ile  Asn His Lys Ile Thr  Glu Glu Gly 
    1085                 1090                 1095             


Tyr Arg  Asn Phe Phe Gln Ala  Leu Asp Asn Met Pro  Asn Leu Gln 
    1100                 1105                 1110             


Glu Leu  Asp Ile Ser Arg His  Phe Thr Glu Cys Ile  Lys Ala Gln 
    1115                 1120                 1125             


Ala Thr  Thr Val Lys Ser Leu  Ser Gln Cys Val Leu  Arg Leu Pro 
    1130                 1135                 1140             


Arg Leu  Ile Arg Leu Asn Met  Leu Ser Trp Leu Leu  Asp Ala Asp 
    1145                 1150                 1155             


Asp Ile  Ala Leu Leu Asn Val  Met Lys Glu Arg His  Pro Gln Ser 
    1160                 1165                 1170             


Lys Tyr  Leu Thr Ile Leu Gln  Lys Trp Ile Leu Pro  Phe Ser Pro 
    1175                 1180                 1185             


Ile Ile  Gln Lys 
    1190         


<210>  4582
<211>  4540
<212>  DNA
<213>  Homosapiens

<400>  4582
atggttgaaa tttataattt gaaattcctc cattccgact tagacaaggg agagggcact     60

gcgaaataca ccctctcagg agatggcgct ggcaccgttt ttaccattga tgaaaccaca    120

ggggacattc atgcaataag gagcctagat agagaagaaa aacctttcta cactcttcgt    180

gctcaggctg tggacataga aaccagaaag cccctggagc ctgaatcaga attcatcatc    240

aaagtgcagg atattaatga taatgagcca aagttttggg atggacctta tgttgctact    300

gtcccagaaa tgtctcctgt gggtgagtag gcaaatcaaa attctgtgag atacaatgag    360

acctcttcaa cattgacttt ttgcaggttg atgtaaacat cttatctatc atctaaaaga    420

attatttttc aattctagaa aatacagttc ttttcattta tttttgtaac ttttttgttt    480

ttctttctgc ttcattatga agataactac aggaatatat aacattagtt cctgttttcc    540

accctgtgaa tttacctgaa ttcatagaat ccttgcgtgc tttaagcaaa aaatgtattt    600

tgtattgaaa ttgattctta tctcaattcc agacacctat acagtgctgg agacacctac    660

cctacaccac gaaatgccag acagtaattc ctagatcaaa gtaaatgatc taaagcatgc    720

atcacatctg atctggaagt ggtccagaaa caggtgtgtt gcatcttctg tagctgtaaa    780

tagagattct ggaagggtga tactgtttcc ttttcagggt aaataaccca tacttgttat    840

gccatcaagc caagcagcaa atgaataatg tcatgaaaat attattagaa caaattaaca    900

aattacaatt acaattatca aattaacaat tagaatatag tagcaccatc attctaaaaa    960

tttaaatttg atataaatat acatttccat atcagcctaa atttacaaag tcctataata   1020

tgtaggatat aaggtcaata agttaagaat tccagcctta aggacaattt taaattataa   1080

tttttattcc tcagtcacca ctgctaatcc ttcaatttat ttcaaagtaa cttctggttt   1140

ttattacatt tggaagataa agcaacttat cacatgtagg ttacaactta aaattcgtgt   1200

atgagccatt gcttatattt tctaaatctg acatgaccca gggggtttct actgctccta   1260

ccaccaccca ggacatgcga tgaagattgt gcacgctacc gtgagggcag aagcaggtta   1320

gtagctgtag gagctgtcac atggatttac tataatgcac ttgaaattgt gtatgtgacc   1380

ttatcaggca tttaaggacc ataatctctc cttgacctaa gaaatcagct tgaagtaatt   1440

cacttagatt tcaaatttta atgtggatac ccaaggctgc aaatctgtta ttcagtacct   1500

gctacacttt tggggttgcc tcttttatgc actgttagaa ttgctagaaa tttagaagtc   1560

caattggaaa gaagcatatc ttgttagaaa gtattcccag aaaatgagga aggctacatt   1620

ttaactgtgt cttgatttta cagggagaaa aataaagtta atattttgag gaaaaaataa   1680

ggcttttaag atgacatgct atatagtaga caaatagttt aactcggtgc ctacttcatg   1740

tacactggat gtgttaacat gaatttatga ccctcagtga ctttttatta ccaaaacagc   1800

ttccttaaag caaacacaca cacatgcctc tacagtattg gaaaattccg tctccttaga   1860

taaaacaatt aggatttttc ttgggccaac tagaataatt agggctgcag agttggagcc   1920

tttatataag gagtttgcag ctcatatccg aagagagaaa tgtatttgga aagtcaaaag   1980

tgtaggtaag tgagaaagca gagtagtttc agcttttgca gttggagtgg gtataattta   2040

ctgtgttgtc ataagatact ggaaagatct ttggaagaat aggttcttaa agtgttttct   2100

catgtgccct tactgacatt tcccattggg ccttcaagac aactccagta aatacttaaa   2160

ttgattttca gtgcactgct ttctttcatt tttatttatt tattttgaga ctgggtcttg   2220

gtctgttgcc ctggctggag tgcaatggcc caatcttagc tcactgaagc cttaaattcc   2280

tgggctgaag agatccctcc acctgagcct ccttaatagc cagtcatgtg ccaccctgcc   2340

tagctatttt tttttttttt tttttttttt ttttactttt tgtagagaag ggatctagct   2400

atgttgccca ggctgttctc aagtagtcct ggcctcaaat gatccctcca ccttggcttc   2460

ccagagcact gggattacag tcatgagcca ccctcctggc tccttttttt tttattttta   2520

ataacagaag ggtatttctt ttgaatgtga aattttacca catggtatga attagtccaa   2580

gtgtttttat actaaattta cataatatac acttttcaag taagtacaaa gaggtataaa   2640

cactgcttat gaattgaatg ttaaaaaata aatctctatg cattactttt gtctttcccc   2700

ataatctcac gtatacacat aaaacaaaaa acaaggagac ccagttatag ttgtggtatc   2760

tgctgtttct gccttgaaat ttccagctta cagctaagca acaactactg tgcatccaga   2820

acttacatct atgttcctag agtacttgaa ccccattctc aagtgcaccc ttcttaccag   2880

gtggaaatag ttcactgctg taataatcta agaaaacatt atgtttctct ctactttttt   2940

ttctctcata taatctaggc aattctccct ctgtatcatt ttcctgagaa aactaaaata   3000

atttttaatc aagaccagat ggaactttgt atggtatatt gacagtatac caattgttgt   3060

gacgaatctt actgcctgtt gtagatatca gtgtttgaag tattccctat gaaataactt   3120

ttctgtccca ataattgaga gggctgtttc atttccaaaa aagggaagaa ttaatcaatt   3180

aaaaatacat atagtgaaat aacctgtttt gtaacataaa acataagatg aagaaatatc   3240

ggaacattga tatgaagttt aacagtaatg gattatatat ccagaaatat gaacaaataa   3300

acctgcaatg aaaatttact aatgttacta attttcactt gtgtaacgtg aacattacaa   3360

agaacatagt gtacaaaggg agaatgttgg tgggtaggat gagtcaagat ttcagaggaa   3420

aatcaatatt taagacttac agcactgtgg aatatattta attttcctaa agttgaagaa   3480

aatttcagtg aatctatgaa ttgtttaaga caaaggtcac tccgttactg acttctgcta   3540

catctaattt tccagggaag taatatttag agataaaaag cttttactct gacctccgga   3600

aattacttaa tgatccagat actcccaaag tcaaagcaaa tccttggaga caagtttgga   3660

ctttatgaat gtggacttaa ttctttaaga tcactagagc aacaataaat tacaggaatg   3720

taccctcttt atatctgatg attatgcata agtggggtgt gcagttttaa gttacttttc   3780

ctacagtgct gacaggttta gagtgttaaa tccatactca acttgtatta tcttcctctg   3840

cttgagctat gccaccttga gtcagctgat ttgactattt ataattagat acctaaccta   3900

tgatatgata tagtagatgt caatagtgac tcatgattta tgtagtaagt cttaccattt   3960

tctaagcagt agtcaggtgc catgtgatct aactaaagat ttgtatttct tattttactt   4020

aacaattaca gtaaccccaa tgcagtatta ttcactgttg gatttttttt aatgtgaaaa   4080

cttaataacc cctgtggata agaaagtaag aatgattctt aggtgcttta ggaccaaatt   4140

aatcagaatt taatatacca ctttgtctag gtgtcatggc ggctaaaata tctttgagaa   4200

agttaaactt agctttcaat ctcagatgat ctacttaaga atttggaaag tttatattat   4260

attatttgag aatggggatt cttgcttaaa cgaaacctga aggatgggca tctttcattc   4320

aatatcttaa aaagaaagtt tagctgacat ttaaataaga aaagatacac ctaaaataaa   4380

gtagaacact ggtttaataa aaatagtgaa caggtactcc cttgcctttc tatttttctc   4440

tcaactctat tttattttac atgaagtttg gggagaaatg ctaagatgaa atttttggtg   4500

gagtctttca gaggttattt aaccagagac tattttcttt                         4540


<210>  4583
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  4583

Met Val Glu Ile Tyr Asn Leu Lys Phe Leu His Ser Asp Leu Asp Lys 
1               5                   10                  15      


Gly Glu Gly Thr Ala Lys Tyr Thr Leu Ser Gly Asp Gly Ala Gly Thr 
            20                  25                  30          


Val Phe Thr Ile Asp Glu Thr Thr Gly Asp Ile His Ala Ile Arg Ser 
        35                  40                  45              


Leu Asp Arg Glu Glu Lys Pro Phe Tyr Thr Leu Arg Ala Gln Ala Val 
    50                  55                  60                  


Asp Ile Glu Thr Arg Lys Pro Leu Glu Pro Glu Ser Glu Phe Ile Ile 
65                  70                  75                  80  


Lys Val Gln Asp Ile Asn Asp Asn Glu Pro Lys Phe Trp Asp Gly Pro 
                85                  90                  95      


Tyr Val Ala Thr Val Pro Glu Met Ser Pro Val Gly Glu 
            100                 105                 


<210>  4584
<211>  2076
<212>  DNA
<213>  Homosapiens

<400>  4584
tccgcgtgtg gaagtctgtg aggcgcagag gtggggcagg ccgtctggct agctaggcgg     60

ctgggagcgt tttcgtggcg gggaacggag gttgaattgc cctgcctggg ctcataggga    120

aggaggatgt gaaggagctt gtgaaggcag aggaagatta ttgaataata aaatacagtt    180

ttgaaaaaaa tggatgaaga acctgaaaga actaagcgat gggaaggagg ctatgaaaga    240

acatgggaga ttcttaaaga agatgaatct ggatcactta aagctacaat agaagacatt    300

ctattcaagg caaagagaaa aagagtattt gagcaccatg gacaagttcg acttggaatg    360

atgcgccacc tttatgtggt agtagatgga tcaagaacaa tggaagacca agatttaaag    420

cctaatagac tgacgtgtac tttaaagttg ttggaatact ttgtagagga atattttgat    480

caaaatccta ttagtcagat tggaataatt gtaactaaga gtaaaagagc tgaaaaattg    540

actgaacttt caggaaaccc aagaaaacat ataacgtctt tgaagaaagc tgtggatatg    600

acctgccatg gagagccatc tctttataat tccctaagca tggctatgca gactctaaaa    660

cacatgcctg gacatacaag tcgagaagta ctaatcatct ttagcagcct tacaacttgc    720

gatccatcta atatttatga tctaatcaag accctaaagg cagctaaaat tagagtatct    780

gttactggat tgtctgcaga agttcgcgtt tgcactgtac ttgctcgtga aactggtggc    840

acgtaccatg ttattttaga tgaaagccat tacaaagagt tgctcacaca tcatgttagt    900

cctcctcctg ctagctcaag ttctgaatgc tcacttattc gtatgggatt tcctcagcac    960

accattgctt ctttatctga ccaggatgca aaaccctctt tcagcatggc gcatttggat   1020

ggcaatactg agccagggct tacattagga ggctatttct gcccacagtg tcgggcaaag   1080

tactgtgagc tacctgttga atgtaaaatc tgtggtctta ctttggtgtc tgctccccac   1140

ttggcacggt cttaccatca tttgtttcct ttggatgctt ttcaagaaat tcccctagaa   1200

gaatataatg gagaaagatt ttgttatgga tgtcaggggg aattgaaaga ccaacatgtt   1260

tatgtttgtg ctgtgtgcca aaatgttttc tgtgtggact gtgatgtttt tgttcatgat   1320

tctctacact gttgccctgg ctgtattcat aagattccag ctccttcagg tgtttgattc   1380

cagcatgtag tatacattgt atgtgttaaa aagaaatttg caactgtgaa taaaaggact   1440

tctttagaag aagcttcatt taaaacatga aaggataatc tgacttaaga aactttttgc   1500

taagaaaagg taatatttta ttaaatttta aatttgtgtt gtcacagaaa tacctgaaat   1560

tcagtagtac ttcattcaat taattttgtt ttctattatt ttgagttata ctgttttcaa   1620

agtcattatg cagtatgtat aaacttataa gaattaaatt gatgtgataa ttttatgttt   1680

ttataattaa atatagaatc tttatgattt atgttaattc attaatttag tgtaagaaga   1740

aagttaagtc tgaatgtaaa ttcagtgtaa gatgaaaatt tatcaatact tatgaaatta   1800

ggctgggcgc tgtggctcac acctgtaatc ccaacacttt gggaggctga ggtgggcaga   1860

tcacttgagg tcaggagttc gagaccagcc tggccaacat ggtgaaaccc cgtcactact   1920

aaaaatacaa aaaataatta gccgggcatg gtggttcacg cctggagtcc cagctacttg   1980

ggaggctgag gcaggagaat cgcttgaacc caggaggcgg aggttgcagg gagccgagat   2040

tgtgccactg cactccaccc tagagtgaga ctccct                             2076


<210>  4585
<211>  395
<212>  PRT
<213>  Homosapiens

<400>  4585

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Lys Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Thr Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Val Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
            340                 345                 350         


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
        355                 360                 365             


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
    370                 375                 380                 


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
385                 390                 395 


<210>  4586
<211>  1991
<212>  DNA
<213>  Homosapiens

<400>  4586
ttctagcggc gccgattatt gaataataaa atacagtttt gaaaaaaatg gatgaagaac     60

ctgaaagaac taagcgatgg gaaggaggct atgaaagaac atgggagatt cttaaagaag    120

atgaatctgg atcacttaaa gctacaatag aagacattct attcaaggca aagagaaaaa    180

gagtatttga gcaccatgga caagttcgac ttggaatgat gcgccacctt tatgtggtag    240

tagatggatc aagaacaatg gaagaccaag atttaaagcc taatagactg acgtgtactt    300

taaagttgtt ggaatacttt gtagaggaat attttgatca aaatcctatt agtcagattg    360

gaataattgt aactaagagt aaaagagctg aaaaattgac tgaactttca ggaaacccaa    420

gaaaacatat aacgtctttg aagaaagctg tggatatgac ctgccatgga gagccatctc    480

tttataattc cctaagcatg gctatgcaga ctctaaatat ctccaagaca catgcctgga    540

catacaagtc gagaagtact aatcatcttt agcagcctta caacttgcga tccatctaat    600

atttatgatc taatcaagac cctaaaggca gctaaaatta gagtatctgt tactggattg    660

tctgcagaag ttcgcgtttg cactgtactt gctcgtgaaa ctggtggtat atatataatt    720

tatttaatat ttgcttataa ttactgtgta ggaaataatt tattaattaa attaggatgt    780

tttaatctgt tctgagctac taaacttaaa gtagtctaaa atatgggcag tcatcttaaa    840

tatatcattg attccataag aaatcatctc caaatgcaaa gagttttcag tacttatgtc    900

agtatttaga ggaggtatta taactcttgg aaagctggaa attttactgt atgtaattct    960

ttataaagat tttataactt gtctttaatt aaattgtaat tacaggccag gcatgatagc   1020

tcatgcctgt aatctcaaca ttttggtagg ccaaggcagg agaatcactt gaggccagaa   1080

gtttgagatc agtctggtta acatagtgag acctgtctct atttatatgt taaaataata   1140

atagtagtaa taataatcaa ttgtaattat agttattcct agagaagttg atttagatat   1200

attacttaaa taaggtttta aaagtgataa tttagctaaa atcattattt taaaaatgta   1260

cattttcaga tgatacaact tttacagaat tacgtagaac gtacagttcg ttatgtctat   1320

gaaggtgttt ttttttccct tttcatcttg ttaggcacgt accatgttat tttagatgaa   1380

agccattaca aagagttgct cacacatcat gttagtcctc ctcctgctag ctcaagttct   1440

gaatgctcac ttattcgtat gggtaagtgt ttttatgttt ttaaaaaata catatctagg   1500

ctctctattt tcatttgcac aagttatttt aatatttaag aatttttaaa gaaaaaatat   1560

gcttgttgaa gcaattttgg aaagtacaga gaagtggaaa aaaaaaatta aaactaccag   1620

tagtcctgtc acccagaaaa tactgttggc tttctttatt tttaaggcta gaaaggtata   1680

aactgtgttt atagaaaaat acttatatta agccgggctc ggtggctcac gcctgtaatc   1740

ccagcacttt gggaggccga ggtgggcgga tcttgaggtc aggagatcga gaccatcctg   1800

gctaacacgg tgaaacccca tctctactaa aaatacaaaa aattagccag gcgtggtggc   1860

gggcgcctgt aatcccagct cctcgggagg ctgaggcagg agaatggcat gaacccggga   1920

ggcagagctg gcaatgagcc gagatcacac cactgcactc tagcctgggc gacagagcga   1980

gactctgtct c                                                        1991


<210>  4587
<211>  174
<212>  PRT
<213>  Homosapiens

<400>  4587

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Lys Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Asn Ile Ser Lys 
145                 150                 155                 160 


Thr His Ala Trp Thr Tyr Lys Ser Arg Ser Thr Asn His Leu 
                165                 170                 


<210>  4588
<211>  2342
<212>  DNA
<213>  Homosapiens

<400>  4588
ttctagcggc gccgattatt gaataataaa atacagtttt gaaaaaaatg gatgaagaac     60

ctgaaagaac taagcgatgg gaaggaggct atgaaagaac atgggagatt cttaaagaag    120

atgaatctgg atcacttaaa gctacaatag aagacattct attcaaggca aagagaaaaa    180

gatgcgccac ctttatgtgg tagtagatgg atcaagaaca atggaagacc aagatttaaa    240

gcctaataga ctgacgtgta ctttaaagtt gttggaatac tttgtagagg aatattttga    300

tcaaaatcct attagtcaga ttggaataat tgtaactaag agtaaaagag ctgaaaaatt    360

gactgaactt tcagatggga gtcttgctct gtcgccaggc tagagtgcag tggcacaatt    420

tcggatcact gcaaagtccg cctcacgggt tcaagcgatt ccctgcctca gcctcctgag    480

tagctggaac tacagatgcc cgccaccacg ccctgctaat tttttgtatt ttagtagata    540

cggggtttca ccatgttggc cagtatggtc tcaatctctt gaccttgtga tcagcccgcc    600

tcagcctctc aaagtgctgg gattacaggc ttgagccacc gcatccggcc ttatcctgaa    660

aatattaaaa tacagttatt gtaatcattt ataaaatcca gttaatctta aaattaaatt    720

cttataaagt taagcatcta atttaaaagg gaaaaagtat aaaaattaaa ctgtagctat    780

tgctaatgaa tcaatttttc tgcttccatg acatacctaa ctgaatttta gtttcaaaac    840

gtagtaatgg cattttttat ttgctttggt atatatgctg ttacaaattt gcatcactga    900

ttctatttta ttttctgtga aatacactct cccttaaatc tggttttcaa ccttttatcc    960

ttgccggcac acataaggga aatgacatac tttcttcatt agtagttttt cattaaatgc   1020

agtgaggagt gaaatgtaca ttggcctgga gtgattcaag aaactcagtt gtgagtaacc   1080

aaaagaatgt cacactagct taagtgcaga aggaaaattt tgggctatgt tcaaaggtgg   1140

gccaattcca tatatagttg ctgcatatgt tggggtcctg gctttgtctg gcttcattct   1200

ctgatagatt ttctggaagt tgaaaagatg tctcttaatt gtcccagttc tacattgtac   1260

ccgtagccta tagcttcagc acacgtctag ggagaactct gattggcctg agttacgatc   1320

tgcccatcca tgaacaaagt ggccaggaaa tgaagtattt tgtttgtacg cttcgattgc   1380

ctgctgatgc ccagagcagg atagaagtag ggtcagcacc acatgaacta agcaggatta   1440

ttatatagtg gaagaaggat ggttcctcca aggtaggaat ataaggtcaa tattttcctc   1500

tcactttacc caccccgagt taccagcagt tttctattgc ttcttttttt ttttttttga   1560

gaaggagtct ctcactctgt cgcccaggcg gtgctgtctt ggctcactgc aacctccgcc   1620

tcccgggttc aagagattct cctgcctccc cctcccgagt agctgggatt acaggtgtgc   1680

gctgccacac ctggctaatt ttatttttag tagagacagg atttcaccat gctggccagg   1740

ctgatctcga actcctgacc tcaggtgatc tacccacctc agcctcccaa agtgttggga   1800

ttacaggcat cagccaccat gcccggcccc agcagttttc tatggatgtt agtgaagtca   1860

tgtataaaga tgaaaaatat tctggagatt ctgacaggcc tcttgaagcc accatttttt   1920

ccctccaatc agaccactgc tgtaaaccac actgacacta ttgtagtatg cttttttcct   1980

atacccataa cacagtggga gattaaaaat aattttgtag ggtaggaaga gaagtggata   2040

gagagccagg agatctaggt ttgggtgctg ctggtcctgc agttaagcag gcatatgtct   2100

ttgggcaagt catttcactt gttttagatt aattttctca cttatgaagt gagggatttg   2160

gactgcttag cgaggtactt ttcatctcta aaatttatga atctaaaata cttgcagtaa   2220

atattaaata ttacaaatgg ttaatatttt aaaacttact cagatgagta aaaactcaag   2280

ggagctccaa gttgatgaat agacaaagaa gacatgattc acacagaaaa aacccagaaa   2340

tt                                                                  2342


<210>  4589
<211>  73
<212>  PRT
<213>  Homosapiens

<400>  4589

Met Arg His Leu Tyr Val Val Val Asp Gly Ser Arg Thr Met Glu Asp 
1               5                   10                  15      


Gln Asp Leu Lys Pro Asn Arg Leu Thr Cys Thr Leu Lys Leu Leu Glu 
            20                  25                  30          


Tyr Phe Val Glu Glu Tyr Phe Asp Gln Asn Pro Ile Ser Gln Ile Gly 
        35                  40                  45              


Ile Ile Val Thr Lys Ser Lys Arg Ala Glu Lys Leu Thr Glu Leu Ser 
    50                  55                  60                  


Asp Gly Ser Leu Ala Leu Ser Pro Gly 
65                  70              


<210>  4590
<211>  1071
<212>  DNA
<213>  Homosapiens

<400>  4590
gccgtctggc tagctaggcg gctgggagcg ttttcgtggc ggggaacgga ggttgaattg     60

ccctgcctgg gctcataggg aaggaggatg tgaaggagct tgtgaaggca gaggaagatt    120

attgaataat aaaatacagt tttgaaaaaa atggatgaag aacctgaaag aactaagcga    180

tgggaaggag gctatgaaag aacatgggag attcttaaag aagatgaatc tggatcactt    240

aaagctacaa tagaagacat tctattcaag gcaaagagaa aaagagtatt tgagcaccat    300

ggacaagttc gacttggaat gatgcgccac ctttatgtgg tagtagatgg atcaagaaca    360

atggaagacc aagatttaaa gcctaataga ctgacgtgta ctttaaagtt gttggaatac    420

tttgtagagg aatattttga tcaaaatcct attagtcaga ttggaataat tgtaactaag    480

agtaaaagag ctgaaaaatt gactgaactt tcaggaaacc caagaaaaca tataacgtct    540

ttgaagaaag ctgtggatat gacctgccat ggagagccat ctctttataa ttccctaagc    600

atggctatgc agactctaaa gttagtatta tacattatgt ataattgaat tagaagtttt    660

ttaaatgagt taagttgaag tgatgtgtta atatggggcc cataaaccca gctataacaa    720

aattgttaag tacgagaatt atgtagtgtt atttatgatg tttagtgtgg tgttggttag    780

taatttttat tttacatttt agtaagatat tgttaaaggt tttataaaaa tataatttaa    840

aactgtcggc agtatcaata gtacaaaaat aggttgatga aaaaatattt tattaaaatg    900

agatttaata tagtataata attgtaagtt ggttgtacct ttattaacat ttattaattt    960

attttgaaag taatggccaa aaccacaatt ccttttgcac caatgtcata tatctgtaaa   1020

ttaatagata tggcaagttc agctatatgg aatagagcta agaccccaaa g            1071


<210>  4591
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  4591

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Lys Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys Leu Val Leu 
145                 150                 155                 160 


Tyr Ile Met Tyr Asn 
                165 


<210>  4592
<211>  983
<212>  DNA
<213>  Homosapiens

<400>  4592
tccggctgag agtccttcta gcggcgccga ttattgaata ataaaataca gttttgaaaa     60

aaatggatga agaacctgaa agaactaagc gatgggaagg aggctatgaa agaacatggg    120

agattcttaa agaagatgaa tctggatcac ttaaagctac aatagaagac attctattca    180

aggcaaagag aaaaagagta tttgagcacc atggacaagt tcgacttgga atgatgcgcc    240

acctttatgt ggtagtagat ggatcaagaa caatggaaga ccaagattta aagcctaata    300

gactgacgtg tactttaaag ttgttggaat actttgtaga ggaatatttt gatcaaaatc    360

ctattagtca gattggaata attgtaacta agagtaaaag agctgaaaaa ttgactgaac    420

tttcaggaaa cccaagaaaa catataacgt ctttgaagaa agctgtggat atgacctgcc    480

atggagagcc atctctttat aattccctaa gcatggctat gcagactcta aagttagtat    540

tatacattat gtataattga attagaagtt ttttaaatga gttaagttga agtgatgtgt    600

taatatgggg cccataaacc cagctataac aaaattgtta agtacgagaa ttatgtagtg    660

ttatttatga tgtttagtgt ggtgttggtt agtaattttt attttacatt ttagtaagat    720

attgttaaag gttttataaa aatataattt aaaactgtcg gcagtatcaa tagtacaaaa    780

ataggttgat gaaaaaatat tttattaaaa tgagatttaa tatagtataa taattgtaag    840

ttggttgtac ctttattaac atttattaat ttattttgaa agtaatggcc aaaaccacaa    900

ttccttttgc accaatgtca tatatctgta aattaataga tatggcaagt tcagctatat    960

ggaatagagc taagacccca aag                                            983


<210>  4593
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  4593

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Lys Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys Leu Val Leu 
145                 150                 155                 160 


Tyr Ile Met Tyr Asn 
                165 


<210>  4594
<211>  2061
<212>  DNA
<213>  Homosapiens

<400>  4594
gccgtctggc tagctaggcg gctgggagcg ttttcgtggc ggggaacgga ggttgaattg     60

ccctgcctgg gctcataggg aaggaggatg tgaaggagct tgtgaaggca gaggaagatt    120

attgaataat aaaatacagt tttgaaaaaa atggatgaag aacctgaaag aactaagcga    180

tgggaaggag gctatgaaag aacatgggag attcttaaag aagatgaatc tggatcactt    240

aaagctacaa tagaagacat tctattcaag gcaaagagaa aaagagtatt tgagcaccat    300

ggacaagttc gacttggaat gatgcgccac ctttatgtgg tagtagatgg atcaagaaca    360

atggaagacc aagatttaaa gcctaataga ctgacgtgta ctttaaagtt gttggaatac    420

tttgtagagg aatattttga tcaaaatcct attagtcaga ttggaataat tgtaactaag    480

agtaaaagag ctgaaaaatt gactgaactt tcaggaaacc caagaaaaca tataacgtct    540

ttgaagaaag ctgtggatat gacctgccat ggagagccat ctctttataa ttccctaagc    600

atggctatgc agactctaaa acacatgcct ggacatacaa gtcgagaagt actaatcatc    660

tttagcagcc ttacaacttg cgatccatct aatatttatg atctaatcaa gaccctaaag    720

gcagctaaaa ttagagtatc tgttactgga ttgtctgcag aagttcgcgt ttgcactgta    780

cttgctcgtg aaactggtgg cacgtaccat gttattttag atgaaagcca ttacaaagag    840

ttgctcacac atcatgttag tcctcctcct gctagctcaa gttctgaatg ctcacttatt    900

cgtatgggat ttcctcagca caccattgct tctttatctg accaggatgc aaaaccctct    960

ttcagcatgg cgcatttgga tggcaatact gagccagggc ttacattagg aggctatttc   1020

tgcccacagt gtcgggcaaa gtactgtgag ctacctgttg aatgtaaaat ctgtggtctt   1080

actttggtgt ctgctcccca cttggcacgg tcttaccatc atttgtttcc tttggatgct   1140

tttcaagaaa ttcccctaga agaatataat ggagaaaggc tgaagaacgg cctaggatga   1200

tgattttgtt atggatgtca gggggaattg aaagaccaac atgtttatgt ttgtgctgtg   1260

tgccaaaatg ttttctgtgt ggactgtgat gtttttgttc atgattctct acactgttgc   1320

cctggctgta ttcataagat tccagctcct tcaggtgttt gattccagca tgtagtatac   1380

attgtatgtg ttaaaaagaa atttgcaact gtgaataaaa ggacttcttt agaagaagct   1440

tcatttaaaa catgaaagga taatctgact taagaaactt tttgctaaga aaaggtaata   1500

ttttattaaa ttttaaattt gtgttgtcac agaaatacct gaaattcagt agtacttcat   1560

tcaattaatt ttgttttcta ttattttgag ttatactgtt ttcaaagtca ttatgcagta   1620

tgtataaact tataagaatt aaattgatgt gataatttta tgtttttata attaaatata   1680

gaatctttat gatttatgtt aattcattaa tttagtgtaa gaagaaagtt aagtctgaat   1740

gtaaattcag tgtaagatga aaatttatca atacttatga aattaggctg ggcgctgtgg   1800

ctcacacctg taatcccaac actttgggag gctgaggtgg gcagatcact tgaggtcagg   1860

agttcgagac cagcctggcc aacatggtga aaccccgtca ctactaaaaa tacaaaaaat   1920

aattagccgg gcatggtggt tcacgcctgg agtcccagct acttgggagg ctgaggcagg   1980

agaatcgctt gaacccagga ggcggaggtt gcagggagcc gagattgtgc cactgcactc   2040

caccctagag tgagactccc t                                             2061


<210>  4595
<211>  349
<212>  PRT
<213>  Homosapiens

<400>  4595

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Lys Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Thr Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Val Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Leu Lys Asn Gly Leu Gly 
            340                 345                 


<210>  4596
<211>  2205
<212>  DNA
<213>  Homosapiens

<400>  4596
tagggttcag tactatcctt gatttcaggt atccactggg ggtcttggaa tgtatcctct     60

gcagataaga ggggactact atagtctttg agaaagaagt gtgtgttact gttttgaagc    120

cacatctctg cactttaaag ctgatccata tgatattgcc acattttagt ttaaagttta    180

tccatatatt gttgtatttt ttattgtata ctctagactt tgtatgaaac aaacctacta    240

gaatgtaagc ttaatgatgt cgggaacatt gtcagtcttg tttatcactc tacccccaga    300

acttgagagt acttggtaaa tattaaatga atcaattaac aattttttga agtgcatagc    360

tcattttaga aaaatttgca ttaaagtgtt taaaatatac tcacaacctt tctttgcatt    420

gttgaaacaa atgagatatt ctatagtcta aatgtgtaat cctatgttta ctgttctttc    480

tgggtaaatt ttttggtagt ataatttgtt gtacctaatt ggagtgtatt ttatctttct    540

tttaagacac atgcctggac atacaagtcg agaagtacta atcatcttta gcagccttac    600

aacttgcgat ccatctaata tttatgatct aatcaaggta gaccaaaaaa tcaaaaccaa    660

agttataact gtaaagagaa ttctgtagca aattgattta tatatatatg tatttttgta    720

tgtgtgattc atctttgtgg tagatgtatt gaatttatta ctagttttca gagcattctt    780

tatttttcaa atacattaaa tcttaaatgt ttttcttctt tcctaaaact atctatctac    840

ttggatttta tgaagaccct aaaggcagct aaaattagag tatctgttac tggattgtct    900

gcagaagttc gcgtttgcac tgtacttgct cgtgaaactg gtggcacgta ccatgttatt    960

ttagatgaaa gccattacaa agagttgctc acacatcatg ttagtcctcc tcctgctagc   1020

tcaagttctg aatgctcact tattcgtatg ggatttcctc agcacaccat tgcttcttta   1080

tctgaccagg atgcaaaacc ctctttcagc atggcgcatt tggatggcaa tactgagcca   1140

gggcttacat taggaggcta tttctgccca cagtgtcggg caaagtactg tgagctacct   1200

gttgaatgta aaatctgtgg tcttactttg gtgtctgctc cccacttggc acggtcttac   1260

catcatttgt ttcctttgga tgcttttcaa gaaattcccc tagaagaata taatggagaa   1320

aggctgaaga acggcctagg atgatgattt tgttatggat gtcaggggga attgaaagac   1380

caacatgttt atgtttgtgc tgtgtgccaa aatgttttct gtgtggactg tgatgttttt   1440

gttcatgatt ctctacactg ttgccctggc tgtattcata agattccagc tccttcaggt   1500

gtttgattcc agcatgtagt atacattgta tgtgttaaaa agaaatttgc aactgtgaat   1560

aaaaggactt ctttagaaga agcttcattt aaaacatgaa aggataatct gacttaagaa   1620

actttttgct aagaaaaggt aatattttat taaattttaa atttgtgttg tcacagaaat   1680

acctgaaatt cagtagtact tcattcaatt aattttgttt tctattattt tgagttatac   1740

tgttttcaaa gtcattatgc agtatgtata aacttataag aattaaattg atgtgataat   1800

tttatgtttt tataattaaa tatagaatct ttatgattta tgttaattca ttaatttagt   1860

gtaagaagaa agttaagtct gaatgtaaat tcagtgtaag atgaaaattt atcaatactt   1920

atgaaattag gctgggcgct gtggctcaca cctgtaatcc caacactttg ggaggctgag   1980

gtgggcagat cacttgaggt caggagttcg agaccagcct ggccaacatg gtgaaacccc   2040

gtcactacta aaaatacaaa aaataattag ccgggcatgg tggttcacgc ctggagtccc   2100

agctacttgg gaggctgagg caggagaatc gcttgaaccc aggaggcgga ggttgcaggg   2160

agccgagatt gtgccactgc actccaccct agagtgagac tccct                   2205


<210>  4597
<211>  164
<212>  PRT
<213>  Homosapiens

<400>  4597

Met Lys Thr Leu Lys Ala Ala Lys Ile Arg Val Ser Val Thr Gly Leu 
1               5                   10                  15      


Ser Ala Glu Val Arg Val Cys Thr Val Leu Ala Arg Glu Thr Gly Gly 
            20                  25                  30          


Thr Tyr His Val Ile Leu Asp Glu Ser His Tyr Lys Glu Leu Leu Thr 
        35                  40                  45              


His His Val Ser Pro Pro Pro Ala Ser Ser Ser Ser Glu Cys Ser Leu 
    50                  55                  60                  


Ile Arg Met Gly Phe Pro Gln His Thr Ile Ala Ser Leu Ser Asp Gln 
65                  70                  75                  80  


Asp Ala Lys Pro Ser Phe Ser Met Ala His Leu Asp Gly Asn Thr Glu 
                85                  90                  95      


Pro Gly Leu Thr Leu Gly Gly Tyr Phe Cys Pro Gln Cys Arg Ala Lys 
            100                 105                 110         


Tyr Cys Glu Leu Pro Val Glu Cys Lys Ile Cys Gly Leu Thr Leu Val 
        115                 120                 125             


Ser Ala Pro His Leu Ala Arg Ser Tyr His His Leu Phe Pro Leu Asp 
    130                 135                 140                 


Ala Phe Gln Glu Ile Pro Leu Glu Glu Tyr Asn Gly Glu Arg Leu Lys 
145                 150                 155                 160 


Asn Gly Leu Gly 
                


<210>  4598
<211>  1453
<212>  DNA
<213>  Homosapiens

<400>  4598
gccgtctggc tagctaggcg gctgggagcg ttttcgtggc ggggaacgga ggttgaattg     60

ccctgcctgg gctcataggg aaggaggatg tgaaggagct tgtgaaggca gaggaagatt    120

attgaataat aaaatacagt tttgaaaaaa atggatgaag aacctgaaag aactaagcga    180

tgggaaggag gctatgaaag aacatgggag attcttaaag aagatgaatc tggatcactt    240

aaagctacaa tagaagacat tctattcaag gcaaagagaa aaagagtatt tgagcaccat    300

ggacaagttc gacttggaat gatgcgccac ctttatgtgg tagtagatgg atcaagaaca    360

atggaagacc aagatttaaa gcctaataga ctgacgtgta ctttaaagtt gttggaatac    420

tttgtagagg aatattttga tcaaaatcct attagtcaga ttggaataat tgtaactaag    480

agtaaaagag ctgaaaaatt gactgaactt tcaggaaacc caagaaaaca tataacgtct    540

ttttcctttg gatgcttttc aagaaattcc cctagaagaa tataatggag aaagattttg    600

ttatggatgt cagggggaat tgaaagacca acatgtttat gtttgtgctg tgtgccaaaa    660

tgttttctgt gtggactgtg atgtttttgt tcatgattct ctacactgtt gccctggctg    720

tattcataag attccagctc cttcaggtgt ttgattccag catgtagtat acattgtatg    780

tgttaaaaag aaatttgcaa ctgtgaataa aaggacttct ttagaagaag cttcatttaa    840

aacatgaaag gataatctga cttaagaaac tttttgctaa gaaaaggtaa tattttatta    900

aattttaaat ttgtgttgtc acagaaatac ctgaaattca gtagtacttc attcaattaa    960

ttttgttttc tattattttg agttatactg ttttcaaagt cattatgcag tatgtataaa   1020

cttataagaa ttaaattgat gtgataattt tatgttttta taattaaata tagaatcttt   1080

atgatttatg ttaattcatt aatttagtgt aagaagaaag ttaagtctga atgtaaattc   1140

agtgtaagat gaaaatttat caatacttat gaaattaggc tgggcgctgt ggctcacacc   1200

tgtaatccca acactttggg aggctgaggt gggcagatca cttgaggtca ggagttcgag   1260

accagcctgg ccaacatggt gaaaccccgt cactactaaa aatacaaaaa ataattagcc   1320

gggcatggtg gttcacgcct ggagtcccag ctacttggga ggctgaggca ggagaatcgc   1380

ttgaacccag gaggcggagg ttgcagggag ccgagattgt gccactgcac tccaccctag   1440

agtgagactc cct                                                      1453


<210>  4599
<211>  144
<212>  PRT
<213>  Homosapiens

<400>  4599

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Phe Ser Phe Gly Cys Phe Ser Arg Asn Ser Pro Arg Arg Ile 
    130                 135                 140                 


<210>  4600
<211>  1999
<212>  DNA
<213>  Homosapiens

<400>  4600
gccgtctggc tagctaggcg gctgggagcg ttttcgtggc ggggaacgga ggttgaattg     60

ccctgcctgg gctcataggg aaggaggatg tgaaggagct tgtgaaggca gaggaagatt    120

attgaataat aaaatacagt tttgaaaaaa atggatgaag aacctgaaag aactaagcga    180

tgggaaggag gctatgaaag aacatgggag attcttaaag aagatgaatc tggatcactt    240

aaagctacaa tagaagacat tctattcaag gcaaagagaa aaagagtatt tgagcaccat    300

ggacaagttc gacttggaat gatgcgccac ctttatgtgg tagtagatgg atcaagaaca    360

atggaagacc aagatttaaa gcctaataga ctgacgtgta ctttaaagtt gttggaatac    420

tttgtagagg aatattttga tcaaaatcct attagtcaga ttggaataat tgtaactaag    480

agtaaaagag ctgaaaaatt gactgaactt tcaggaaacc caagaaaaca tataacgtct    540

ttgaagaaag ctgtggatat gacctgccat ggagagccat ctctttataa ttccctaagc    600

atggctatgc agactctaaa acacatgcct ggacatacaa gtcgagaagt actaatcatc    660

tttagcagcc ttacaacttg cgatccatct aatatttatg atctaatcaa gaccctaaag    720

gcagctaaaa ttagagtatc tgttactgga ttgtctgcag aagttcgcgt ttgcactgta    780

cttgctcgtg aaactggtgg cacgtaccat gttattttag atgaaagcca ttacaaagag    840

ttgctcacac atcatgttag tcctcctcct gctagctcaa gttctgaatg ctcacttatt    900

cgtatgggat gcaaaaccct ctttcagcat ggcgcatttg gatggcaata ctgagccagg    960

gcttacatta ggaggctatt tctgcccaca gtgtcgggca aagtactgtg agctacctgt   1020

tgaatgtaaa atctgtggtc ttactttggt gtctgctccc cacttggcac ggtcttacca   1080

tcatttgttt cctttggatg cttttcaaga aattccccta gaagaatata atggagaaag   1140

attttgttat ggatgtcagg gggaattgaa agaccaacat gtttatgttt gtgctgtgtg   1200

ccaaaatgtt ttctgtgtgg actgtgatgt ttttgttcat gattctctac actgttgccc   1260

tggctgtatt cataagattc cagctccttc aggtgtttga ttccagcatg tagtatacat   1320

tgtatgtgtt aaaaagaaat ttgcaactgt gaataaaagg acttctttag aagaagcttc   1380

atttaaaaca tgaaaggata atctgactta agaaactttt tgctaagaaa aggtaatatt   1440

ttattaaatt ttaaatttgt gttgtcacag aaatacctga aattcagtag tacttcattc   1500

aattaatttt gttttctatt attttgagtt atactgtttt caaagtcatt atgcagtatg   1560

tataaactta taagaattaa attgatgtga taattttatg tttttataat taaatataga   1620

atctttatga tttatgttaa ttcattaatt tagtgtaaga agaaagttaa gtctgaatgt   1680

aaattcagtg taagatgaaa atttatcaat acttatgaaa ttaggctggg cgctgtggct   1740

cacacctgta atcccaacac tttgggaggc tgaggtgggc agatcacttg aggtcaggag   1800

ttcgagacca gcctggccaa catggtgaaa ccccgtcact actaaaaata caaaaaataa   1860

ttagccgggc atggtggttc acgcctggag tcccagctac ttgggaggct gaggcaggag   1920

aatcgcttga acccaggagg cggaggttgc agggagccga gattgtgcca ctgcactcca   1980

ccctagagtg agactccct                                                1999


<210>  4601
<211>  267
<212>  PRT
<213>  Homosapiens

<400>  4601

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Lys Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Thr Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Val Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Cys Lys Thr 
                245                 250                 255     


Leu Phe Gln His Gly Ala Phe Gly Trp Gln Tyr 
            260                 265         


<210>  4602
<211>  2320
<212>  DNA
<213>  Homosapiens

<400>  4602
tgcccggcct tggatcactt ttttaaaatg ttattttctt ctattttaca aaaatgttaa     60

atgttacaat gaaaatttat tacatttata ttgaaaaaag tataactttt aatagaaaaa    120

taatctcctt atttaatatg tatgttttta aatgttaatg aaataaaatg cttttctact    180

tttggccttt tatattacca gtcgacctct cttttccacg gtcttctcat gtgtttaatg    240

atgtcagtaa ctatcaacct tattgtgtgt ttcaaggatt gagttaatac agatgatgcg    300

tttagaataa tgcttgatgt aaacattcaa tacattttag atcttatgtt tggctaatct    360

ttttgattta ctgatatatt ttcttatttc attttaaagt tatttaaatt tataatttat    420

ttattagagt cctttaggaa tgttaaccct tctcagtcac ccgatgcaaa tatttttctt    480

gttggttatt tgcctttact tttatttatt tgttttgata tgtagataca tttacatttt    540

ttatgtaata tatcttttta aaaatggttt ctgcttttcc tgaacatgtt ttcagaattt    600

aaaattgtat atggaaaaca aattacatga aagatttgag catttcaaaa ttttaaacat    660

aaaagcataa acgtagataa aatgaaggtg tactatgata tcttcagttt tatcagaaat    720

gatgtaaaaa ttacaacctc tttaaaaagt agtgttaatc attaagttag aaaatatata    780

gctgggcatg gtggcagatg cctgtaatcc cagctacatg ggaaggtgag gtgggagaat    840

cgcttgaacc caggcagtgg aggatgcagt gagccaagat catgccactg caccccagcc    900

tgggtgacag aacaagactc catctcaaga aaaaaaaaaa agaaaaatat atatatgaac    960

ttcagaatct gaggtcatat atagacaggt ctttcccccg tttcctctac tttttcttgt   1020

agcttggaat tagtcagttt catcatgcta taataagctt atctgaaagg cagtaaagtg   1080

atattttgta caacttcatt ggctttttga gaagaacatt tttaggttct tagtcctaga   1140

attttgctgt ttgcttggaa aaagaaagta atacattttc ttctatgaag gatttcctca   1200

gcacaccatt gcttctttat ctgaccagga tgcaaaaccc tctttcagca tggcgcattt   1260

ggatggcaat actgagccag ggcttacatt aggaggctat ttctgcccac agtgtcgggc   1320

aaagtactgt gagctacctg ttgaatgtaa aatctgtggt cttactttgg tgtctgctcc   1380

ccacttggca cggtcttacc atcatttgtt tcctttggat gcttttcaag aaattcccct   1440

agaagaatat aatggagaaa gattttgtta tggatgtcag ggggaattga aagaccaaca   1500

tgtttatgtt tgtgctgtgt gccaaaatgt tttctgtgtg gactgtgatg tttttgttca   1560

tgattctcta cactgttgcc ctggctgtat tcataagatt ccagctcctt caggtgtttg   1620

attccagcat gtagtataca ttgtatgtgt taaaaagaaa tttgcaactg tgaataaaag   1680

gacttcttta gaagaagctt catttaaaac atgaaaggat aatctgactt aagaaacttt   1740

ttgctaagaa aaggtaatat tttattaaat tttaaatttg tgttgtcaca gaaatacctg   1800

aaattcagta gtacttcatt caattaattt tgttttctat tattttgagt tatactgttt   1860

tcaaagtcat tatgcagtat gtataaactt ataagaatta aattgatgtg ataattttat   1920

gtttttataa ttaaatatag aatctttatg atttatgtta attcattaat ttagtgtaag   1980

aagaaagtta agtctgaatg taaattcagt gtaagatgaa aatttatcaa tacttatgaa   2040

attaggctgg gcgctgtggc tcacacctgt aatcccaaca ctttgggagg ctgaggtggg   2100

cagatcactt gaggtcagga gttcgagacc agcctggcca acatggtgaa accccgtcac   2160

tactaaaaat acaaaaaata attagccggg catggtggtt cacgcctgga gtcccagcta   2220

cttgggaggc tgaggcagga gaatcgcttg aacccaggag gcggaggttg cagggagccg   2280

agattgtgcc actgcactcc accctagagt gagactccct                         2320


<210>  4603
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  4603

Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
1               5                   10                  15      


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
            20                  25                  30          


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
        35                  40                  45              


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
    50                  55                  60                  


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
65                  70                  75                  80  


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
                85                  90                  95      


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
            100                 105                 110         


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
        115                 120             


<210>  4604
<211>  1958
<212>  DNA
<213>  Homosapiens

<400>  4604
ccggctgaga gtccttctag cggcgccggc tggagtgcag tggcacaacc ttggctcgct     60

ccagtgtcta cctgccaggt tcaagtgatt ctcctgcctc agcctcccga gtagctggga    120

ttacagatta ttgaataata aaatacagtt ttgaaaaaaa tggatgaaga acctgaaaga    180

actaagcgat gggaaggagg ctatgaaaga acatgggaga ttcttaaaga agatgaatct    240

ggatcactta aagctacaat agaagacatt ctattcaagg caaagagaaa aagatgcgcc    300

acctttatgt ggtagtagat ggatcaagaa caatggaaga ccaagattta aagcctaata    360

gactgacgtg tactttaaag attggaataa ttgtaactaa gagtaaaaga gctgaaaaat    420

tgactgaact ttcaggaaac ccaagaaaac atataacgtc tttgaagaaa gctgtggata    480

tgacctgcca tggagagcca tctctttata attccctaag catggctatg cagactctaa    540

aacacatgcc tggacataca agtcgagaag tactaatcat ctttagcagc cttacaactt    600

gcgatccatc taatatttat gatctaatca agaccctaaa ggcagctaaa attagagtat    660

ctgttactgg attgtctgca gaagttcgcg tttgcactgt acttgctcgt gaaactggtg    720

gcacgtacca tgttatttta gatgaaagcc attacaaaga gttgctcaca catcatgtta    780

gtcctcctcc tgctagctca agttctgaat gctcacttat tcgtatggga tttcctcagc    840

acaccattgc ttctttatct gaccaggatg caaaaccctc tttcagcatg gcgcatttgg    900

atggcaatac tgagccaggg cttacattag gaggctattt ctgcccacag tgtcgggcaa    960

agtactgtga gctacctgtt gaatgtaaaa tctgtggtct tactttggtg tctgctcccc   1020

acttggcacg gtcttaccat catttgtttc ctttggatgc ttttcaagaa attcccctag   1080

aagaatataa tggagaaaga ttttgttatg gatgtcaggg ggaattgaaa gaccaacatg   1140

tttatgtttg tgctgtgtgc caaaatgttt tctgtgtgga ctgtgatgtt tttgttcatg   1200

attctctaca ctgttgccct ggctgtattc ataagattcc agctccttca ggtgtttgat   1260

tccagcatgt agtatacatt gtatgtgtta aaaagaaatt tgcaactgtg aataaaagga   1320

cttctttaga agaagcttca tttaaaacat gaaaggataa tctgacttaa gaaacttttt   1380

gctaagaaaa ggtaatattt tattaaattt taaatttgtg ttgtcacaga aatacctgaa   1440

attcagtagt acttcattca attaattttg ttttctatta ttttgagtta tactgttttc   1500

aaagtcatta tgcagtatgt ataaacttat aagaattaaa ttgatgtgat aattttatgt   1560

ttttataatt aaatatagaa tctttatgat ttatgttaat tcattaattt agtgtaagaa   1620

gaaagttaag tctgaatgta aattcagtgt aagatgaaaa tttatcaata cttatgaaat   1680

taggctgggc gctgtggctc acacctgtaa tcccaacact ttgggaggct gaggtgggca   1740

gatcacttga ggtcaggagt tcgagaccag cctggccaac atggtgaaac cccgtcacta   1800

ctaaaaatac aaaaaataat tagccgggca tggtggttca cgcctggagt cccagctact   1860

tgggaggctg aggcaggaga atcgcttgaa cccaggaggc ggaggttgca gggagccgag   1920

attgtgccac tgcactccac cctagagtga gactccct                           1958


<210>  4605
<211>  321
<212>  PRT
<213>  Homosapiens

<400>  4605

Met Arg His Leu Tyr Val Val Val Asp Gly Ser Arg Thr Met Glu Asp 
1               5                   10                  15      


Gln Asp Leu Lys Pro Asn Arg Leu Thr Cys Thr Leu Lys Ile Gly Ile 
            20                  25                  30          


Ile Val Thr Lys Ser Lys Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly 
        35                  40                  45              


Asn Pro Arg Lys His Ile Thr Ser Leu Lys Lys Ala Val Asp Met Thr 
    50                  55                  60                  


Cys His Gly Glu Pro Ser Leu Tyr Asn Ser Leu Ser Met Ala Met Gln 
65                  70                  75                  80  


Thr Leu Lys His Met Pro Gly His Thr Ser Arg Glu Val Leu Ile Ile 
                85                  90                  95      


Phe Ser Ser Leu Thr Thr Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile 
            100                 105                 110         


Lys Thr Leu Lys Ala Ala Lys Ile Arg Val Ser Val Thr Gly Leu Ser 
        115                 120                 125             


Ala Glu Val Arg Val Cys Thr Val Leu Ala Arg Glu Thr Gly Gly Thr 
    130                 135                 140                 


Tyr His Val Ile Leu Asp Glu Ser His Tyr Lys Glu Leu Leu Thr His 
145                 150                 155                 160 


His Val Ser Pro Pro Pro Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile 
                165                 170                 175     


Arg Met Gly Phe Pro Gln His Thr Ile Ala Ser Leu Ser Asp Gln Asp 
            180                 185                 190         


Ala Lys Pro Ser Phe Ser Met Ala His Leu Asp Gly Asn Thr Glu Pro 
        195                 200                 205             


Gly Leu Thr Leu Gly Gly Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr 
    210                 215                 220                 


Cys Glu Leu Pro Val Glu Cys Lys Ile Cys Gly Leu Thr Leu Val Ser 
225                 230                 235                 240 


Ala Pro His Leu Ala Arg Ser Tyr His His Leu Phe Pro Leu Asp Ala 
                245                 250                 255     


Phe Gln Glu Ile Pro Leu Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr 
            260                 265                 270         


Gly Cys Gln Gly Glu Leu Lys Asp Gln His Val Tyr Val Cys Ala Val 
        275                 280                 285             


Cys Gln Asn Val Phe Cys Val Asp Cys Asp Val Phe Val His Asp Ser 
    290                 295                 300                 


Leu His Cys Cys Pro Gly Cys Ile His Lys Ile Pro Ala Pro Ser Gly 
305                 310                 315                 320 


Val 
    


<210>  4606
<211>  1978
<212>  DNA
<213>  Homosapiens

<400>  4606
tgggagcgtt ttcgtggcgg ggaacggagg ttgaattgcc ctgcctgggc tcatagggaa     60

ggaggatgtg aaggagcttg tgaaggcaga ggaagattat tgaataataa aatacagttt    120

tgaaaaaaat ggatgaagaa cctgaaagaa ctaagcgatg ggaaggaggc tatgaaagaa    180

catgggagat tcttaaagaa gatgaatctg gatcacttaa agctacaata gaagacattc    240

tattcaaggc aaagagaaaa agatgcgcca cctttatgtg gtagtagatg gatcaagaac    300

aatggaagac caagatttaa agcctaatag actgacgtgt actttaaagt tgttggaata    360

ctttgtagag gaatattttg atcaaaatcc tattagtcag attggaataa ttgtaactaa    420

gagtaaaaga gctgaaaaat tgactgaact ttcaggaaac ccaagaaaac atataacgtc    480

tttgaagaaa gctgtggata tgacctgcca tggagagcca tctctttata attccctaag    540

catggctatg cagactctaa aacacatgcc tggacataca agtcgagaag tactaatcat    600

ctttagcagc cttacaactt gcgatccatc taatatttat gatctaatca agaccctaaa    660

ggcagctaaa attagagtat ctgttactgg attgtctgca gaagttcgcg tttgcactgt    720

acttgctcgt gaaactggtg gcacgtacca tgttatttta gatgaaagcc attacaaaga    780

gttgctcaca catcatgtta gtcctcctcc tgctagctca agttctgaat gctcacttat    840

tcgtatggga tttcctcagc acaccattgc ttctttatct gaccaggatg caaaaccctc    900

tttcagcatg gcgcatttgg atggcaatac tgagccaggg cttacattag gaggctattt    960

ctgcccacag tgtcgggcaa agtactgtga gctacctgtt gaatgtaaaa tctgtggtct   1020

tactttggtg tctgctcccc acttggcacg gtcttaccat catttgtttc ctttggatgc   1080

ttttcaagaa attcccctag aagaatataa tggagaaaga ttttgttatg gatgtcaggg   1140

ggaattgaaa gaccaacatg tttatgtttg tgctgtgtgc caaaatgttt tctgtgtgga   1200

ctgtgatgtt tttgttcatg attctctaca ctgttgccct ggctgtattc ataagattcc   1260

agctccttca ggtgtttgat tccagcatgt agtatacatt gtatgtgtta aaaagaaatt   1320

tgcaactgtg aataaaagga cttctttaga agaagcttca tttaaaacat gaaaggataa   1380

tctgacttaa gaaacttttt gctaagaaaa ggtaatattt tattaaattt taaatttgtg   1440

ttgtcacaga aatacctgaa attcagtagt acttcattca attaattttg ttttctatta   1500

ttttgagtta tactgttttc aaagtcatta tgcagtatgt ataaacttat aagaattaaa   1560

ttgatgtgat aattttatgt ttttataatt aaatatagaa tctttatgat ttatgttaat   1620

tcattaattt agtgtaagaa gaaagttaag tctgaatgta aattcagtgt aagatgaaaa   1680

tttatcaata cttatgaaat taggctgggc gctgtggctc acacctgtaa tcccaacact   1740

ttgggaggct gaggtgggca gatcacttga ggtcaggagt tcgagaccag cctggccaac   1800

atggtgaaac cccgtcacta ctaaaaatac aaaaaataat tagccgggca tggtggttca   1860

cgcctggagt cccagctact tgggaggctg aggcaggaga atcgcttgaa cccaggaggc   1920

ggaggttgca gggagccgag attgtgccac tgcactccac cctagagtga gactccct     1978


<210>  4607
<211>  338
<212>  PRT
<213>  Homosapiens

<400>  4607

Met Arg His Leu Tyr Val Val Val Asp Gly Ser Arg Thr Met Glu Asp 
1               5                   10                  15      


Gln Asp Leu Lys Pro Asn Arg Leu Thr Cys Thr Leu Lys Leu Leu Glu 
            20                  25                  30          


Tyr Phe Val Glu Glu Tyr Phe Asp Gln Asn Pro Ile Ser Gln Ile Gly 
        35                  40                  45              


Ile Ile Val Thr Lys Ser Lys Arg Ala Glu Lys Leu Thr Glu Leu Ser 
    50                  55                  60                  


Gly Asn Pro Arg Lys His Ile Thr Ser Leu Lys Lys Ala Val Asp Met 
65                  70                  75                  80  


Thr Cys His Gly Glu Pro Ser Leu Tyr Asn Ser Leu Ser Met Ala Met 
                85                  90                  95      


Gln Thr Leu Lys His Met Pro Gly His Thr Ser Arg Glu Val Leu Ile 
            100                 105                 110         


Ile Phe Ser Ser Leu Thr Thr Cys Asp Pro Ser Asn Ile Tyr Asp Leu 
        115                 120                 125             


Ile Lys Thr Leu Lys Ala Ala Lys Ile Arg Val Ser Val Thr Gly Leu 
    130                 135                 140                 


Ser Ala Glu Val Arg Val Cys Thr Val Leu Ala Arg Glu Thr Gly Gly 
145                 150                 155                 160 


Thr Tyr His Val Ile Leu Asp Glu Ser His Tyr Lys Glu Leu Leu Thr 
                165                 170                 175     


His His Val Ser Pro Pro Pro Ala Ser Ser Ser Ser Glu Cys Ser Leu 
            180                 185                 190         


Ile Arg Met Gly Phe Pro Gln His Thr Ile Ala Ser Leu Ser Asp Gln 
        195                 200                 205             


Asp Ala Lys Pro Ser Phe Ser Met Ala His Leu Asp Gly Asn Thr Glu 
    210                 215                 220                 


Pro Gly Leu Thr Leu Gly Gly Tyr Phe Cys Pro Gln Cys Arg Ala Lys 
225                 230                 235                 240 


Tyr Cys Glu Leu Pro Val Glu Cys Lys Ile Cys Gly Leu Thr Leu Val 
                245                 250                 255     


Ser Ala Pro His Leu Ala Arg Ser Tyr His His Leu Phe Pro Leu Asp 
            260                 265                 270         


Ala Phe Gln Glu Ile Pro Leu Glu Glu Tyr Asn Gly Glu Arg Phe Cys 
        275                 280                 285             


Tyr Gly Cys Gln Gly Glu Leu Lys Asp Gln His Val Tyr Val Cys Ala 
    290                 295                 300                 


Val Cys Gln Asn Val Phe Cys Val Asp Cys Asp Val Phe Val His Asp 
305                 310                 315                 320 


Ser Leu His Cys Cys Pro Gly Cys Ile His Lys Ile Pro Ala Pro Ser 
                325                 330                 335     


Gly Val 
        


<210>  4608
<211>  1952
<212>  DNA
<213>  Homosapiens

<400>  4608
gtttccggct gagagtcctt ctagcggcgc cgattattga ataataaaat acagttttga     60

aaaaaatgga tgaagaacct gaaagaacta agcgatggga aggaggctat gaaagaacat    120

gggagattct taaagaagat gaatctggat cacttaaagc tacaatagaa gacattctat    180

tcaaggcaaa gagaaaaaga gtatttgagc accatggaca agttcgactt ggaatgatgc    240

gccaccttta tgtggtagta gatggatcaa gaacaatgga agaccaagat ttaaagccta    300

atagactgac gtgtacttta aagttgttgg aatactttgt agaggaatat tttgatcaaa    360

atcctattag tcagattgga ataattgtaa ctaagagtaa aagagctgaa aaattgactg    420

aactttcagg aaacccaaga aaacatataa cgtctttgaa gaaagctgtg gatatgacct    480

gccatggaga gccatctctt tataattccc taagcatggc tatgcagact ctaaaacaca    540

tgcctggaca tacaagtcga gaagtactaa tcatctttag cagccttaca acttgcgatc    600

catctaatat ttatgatcta atcaagaccc taaaggcagc taaaattaga gtatctgtta    660

ctggattgtc tgcagaagtt cgcgtttgca ctgtacttgc tcgtgaaact ggtggcacgt    720

accatgttat tttagatgaa agccattaca aagagttgct cacacatcat gttagtcctc    780

ctcctgctag ctcaagttct gaatgctcac ttattcgtat gggatttcct cagcacacca    840

ttgcttcttt atctgaccag gatgcaaaac cctctttcag catggcgcat ttggatggca    900

atactgagcc agggcttaca ttaggaggct atttctgccc acagtgtcgg gcaaagtact    960

gtgagctacc tgttgaatgt aaaatctgtg gtcttacttt ggtgtctgct ccccacttgg   1020

cacggtctta ccatcatttg tttcctttgg atgcttttca agaaattccc ctagaagaat   1080

ataatggaga aagattttgt tatggatgtc agggggaatt gaaagaccaa catgtttatg   1140

tttgtgctgt gtgccaaaat gttttctgtg tggactgtga tgtttttgtt catgattctc   1200

tacactgttg ccctggctgt attcataaga ttccagctcc ttcaggtgtt tgattccagc   1260

atgtagtata cattgtatgt gttaaaaaga aatttgcaac tgtgaataaa aggacttctt   1320

tagaagaagc ttcatttaaa acatgaaagg ataatctgac ttaagaaact ttttgctaag   1380

aaaaggtaat attttattaa attttaaatt tgtgttgtca cagaaatacc tgaaattcag   1440

tagtacttca ttcaattaat tttgttttct attattttga gttatactgt tttcaaagtc   1500

attatgcagt atgtataaac ttataagaat taaattgatg tgataatttt atgtttttat   1560

aattaaatat agaatcttta tgatttatgt taattcatta atttagtgta agaagaaagt   1620

taagtctgaa tgtaaattca gtgtaagatg aaaatttatc aatacttatg aaattaggct   1680

gggcgctgtg gctcacacct gtaatcccaa cactttggga ggctgaggtg ggcagatcac   1740

ttgaggtcag gagttcgaga ccagcctggc caacatggtg aaaccccgtc actactaaaa   1800

atacaaaaaa taattagccg ggcatggtgg ttcacgcctg gagtcccagc tacttgggag   1860

gctgaggcag gagaatcgct tgaacccagg aggcggaggt tgcagggagc cgagattgtg   1920

ccactgcact ccaccctaga gtgagactcc ct                                 1952


<210>  4609
<211>  395
<212>  PRT
<213>  Homosapiens

<400>  4609

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Lys Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Thr Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Val Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
            340                 345                 350         


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
        355                 360                 365             


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
    370                 375                 380                 


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
385                 390                 395 


<210>  4610
<211>  2169
<212>  DNA
<213>  Homosapiens

<400>  4610
gtgtggaagt ctgtgaggcg cagaggtggg gcaggccgtc tggctagcta ggcggctggg     60

agcgttttcg tggcggggaa cggaggttga attgccctgc ctgggctcat agggaaggag    120

gatgtgaagg agcttgtgaa ggcagaggaa ggctggagtg cagtggcaca accttggctc    180

gctccagtgt ctacctgcca ggttcaagtg attctcctgc ctcagcctcc cgagtagctg    240

ggattacaga ttattgaata ataaaataca gttttgaaaa aaatggatga agaacctgaa    300

agaactaagc gatgggaagg aggctatgaa agaacatggg agattcttaa agaagatgaa    360

tctggatcac ttaaagctac aatagaagac attctattca aggcaaagag aaaaagagta    420

tttgagcacc atggacaagt tcgacttgga atgatgcgcc acctttatgt ggtagtagat    480

ggatcaagaa caatggaaga ccaagattta aagcctaata gactgacgtg tactttaaag    540

ttgttggaat actttgtaga ggaatatttt gatcaaaatc ctattagtca gattggaata    600

attgtaacta agagtaaaag agctgaaaaa ttgactgaac tttcaggaaa cccaagaaaa    660

catataacgt ctttgaagaa agctgtggat atgacctgcc atggagagcc atctctttat    720

aattccctaa gcatggctat gcagactcta aaacacatgc ctggacatac aagtcgagaa    780

gtactaatca tctttagcag ccttacaact tgcgatccat ctaatattta tgatctaatc    840

aagaccctaa aggcagctaa aattagagta tctgttactg gattgtctgc agaagttcgc    900

gtttgcactg tacttgctcg tgaaactggt ggcacgtacc atgttatttt agatgaaagc    960

cattacaaag agttgctcac acatcatgtt agtcctcctc ctgctagctc aagttctgaa   1020

tgctcactta ttcgtatggg atttcctcag cacaccattg cttctttatc tgaccaggat   1080

gcaaaaccct ctttcagcat ggcgcatttg gatggcaata ctgagccagg gcttacatta   1140

ggaggctatt tctgcccaca gtgtcgggca aagtactgtg agctacctgt tgaatgtaaa   1200

atctgtggtc ttactttggt gtctgctccc cacttggcac ggtcttacca tcatttgttt   1260

cctttggatg cttttcaaga aattccccta gaagaatata atggagaaag attttgttat   1320

ggatgtcagg gggaattgaa agaccaacat gtttatgttt gtgctgtgtg ccaaaatgtt   1380

ttctgtgtgg actgtgatgt ttttgttcat gattctctac actgttgccc tggctgtatt   1440

cataagattc cagctccttc aggtgtttga ttccagcatg tagtatacat tgtatgtgtt   1500

aaaaagaaat ttgcaactgt gaataaaagg acttctttag aagaagcttc atttaaaaca   1560

tgaaaggata atctgactta agaaactttt tgctaagaaa aggtaatatt ttattaaatt   1620

ttaaatttgt gttgtcacag aaatacctga aattcagtag tacttcattc aattaatttt   1680

gttttctatt attttgagtt atactgtttt caaagtcatt atgcagtatg tataaactta   1740

taagaattaa attgatgtga taattttatg tttttataat taaatataga atctttatga   1800

tttatgttaa ttcattaatt tagtgtaaga agaaagttaa gtctgaatgt aaattcagtg   1860

taagatgaaa atttatcaat acttatgaaa ttaggctggg cgctgtggct cacacctgta   1920

atcccaacac tttgggaggc tgaggtgggc agatcacttg aggtcaggag ttcgagacca   1980

gcctggccaa catggtgaaa ccccgtcact actaaaaata caaaaaataa ttagccgggc   2040

atggtggttc acgcctggag tcccagctac ttgggaggct gaggcaggag aatcgcttga   2100

acccaggagg cggaggttgc agggagccga gattgtgcca ctgcactcca ccctagagtg   2160

agactccct                                                           2169


<210>  4611
<211>  395
<212>  PRT
<213>  Homosapiens

<400>  4611

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Lys Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Thr Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Val Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
            340                 345                 350         


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
        355                 360                 365             


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
    370                 375                 380                 


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
385                 390                 395 


<210>  4612
<211>  1902
<212>  DNA
<213>  Homosapiens

<400>  4612
atggatgaag aacctgaaag aactaagcga tgggaaggag gctatgaaag aacatgggag     60

attcttaaag aagatgaatc tggatcactt aaagctacaa tagaagacat tctattcaag    120

gcaaagagaa aaaggtatgt aaccttccta ttatttgagc accatggaca agttcgactt    180

ggaatgatgc gccaccttta tgtggtagta gatggatcaa gaacaatgga agaccaagat    240

ttaaagccta atagactgac gtgtacttta aagttgttgg aatactttgt agaggaatat    300

tttgatcaaa atcctattag tcagattgga ataattgtaa ctaagagtaa aagagctgaa    360

aaattgactg aactttcagg aaacccaaga aaacatataa cgtctttgaa gaaagctgtg    420

gatatgacct gccatggaga gccatctctt tataattccc taagcatggc tatgcagact    480

ctaaaacaca tgcctggaca tacaagtcga gaagtactaa tcatctttag cagccttaca    540

acttgcgatc catctaatat ttatgatcta atcaagaccc taaaggcagc taaaattaga    600

gtatctgtta ctggattgtc tgcagaagtt cgcgtttgca ctgtacttgc tcgtgaaact    660

ggtggcacgt accatgttat tttagatgaa agccattaca aagagttgct cacacatcat    720

gttagtcctc ctcctgctag ctcaagttct gaatgctcac ttattcgtat gggatttcct    780

cagcacacca ttgcttcttt atctgaccag gatgcaaaac cctctttcag catggcgcat    840

ttggatggca atactgagcc agggcttaca ttaggaggct atttctgccc acagtgtcgg    900

gcaaagtact gtgagctacc tgttgaatgt aaaatctgtg gtcttacttt ggtgtctgct    960

ccccacttgg cacggtctta ccatcatttg tttcctttgg atgcttttca agaaattccc   1020

ctagaagaat ataatggaga aagattttgt tatggatgtc agggggaatt gaaagaccaa   1080

catgtttatg tttgtgctgt gtgccaaaat gttttctgtg tggactgtga tgtttttgtt   1140

catgattctc tacactgttg ccctggctgt attcataaga ttccagctcc ttcaggtgtt   1200

tgattccagc atgtagtata cattgtatgt gttaaaaaga aatttgcaac tgtgaataaa   1260

aggacttctt tagaagaagc ttcatttaaa acatgaaagg ataatctgac ttaagaaact   1320

ttttgctaag aaaaggtaat attttattaa attttaaatt tgtgttgtca cagaaatacc   1380

tgaaattcag tagtacttca ttcaattaat tttgttttct attattttga gttatactgt   1440

tttcaaagtc attatgcagt atgtataaac ttataagaat taaattgatg tgataatttt   1500

atgtttttat aattaaatat agaatcttta tgatttatgt taattcatta atttagtgta   1560

agaagaaagt taagtctgaa tgtaaattca gtgtaagatg aaaatttatc aatacttatg   1620

aaattaggct gggcgctgtg gctcacacct gtaatcccaa cactttggga ggctgaggtg   1680

ggcagatcac ttgaggtcag gagttcgaga ccagcctggc caacatggtg aaaccccgtc   1740

actactaaaa atacaaaaaa taattagccg ggcatggtgg ttcacgcctg gagtcccagc   1800

tacttgggag gctgaggcag gagaatcgct tgaacccagg aggcggaggt tgcagggagc   1860

cgagattgtg ccactgcact ccaccctaga gtgagactcc ct                      1902


<210>  4613
<211>  400
<212>  PRT
<213>  Homosapiens

<400>  4613

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Tyr Val Thr 
        35                  40                  45              


Phe Leu Leu Phe Glu His His Gly Gln Val Arg Leu Gly Met Met Arg 
    50                  55                  60                  


His Leu Tyr Val Val Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp 
65                  70                  75                  80  


Leu Lys Pro Asn Arg Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe 
                85                  90                  95      


Val Glu Glu Tyr Phe Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile 
            100                 105                 110         


Val Thr Lys Ser Lys Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn 
        115                 120                 125             


Pro Arg Lys His Ile Thr Ser Leu Lys Lys Ala Val Asp Met Thr Cys 
    130                 135                 140                 


His Gly Glu Pro Ser Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr 
145                 150                 155                 160 


Leu Lys His Met Pro Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe 
                165                 170                 175     


Ser Ser Leu Thr Thr Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys 
            180                 185                 190         


Thr Leu Lys Ala Ala Lys Ile Arg Val Ser Val Thr Gly Leu Ser Ala 
        195                 200                 205             


Glu Val Arg Val Cys Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr 
    210                 215                 220                 


His Val Ile Leu Asp Glu Ser His Tyr Lys Glu Leu Leu Thr His His 
225                 230                 235                 240 


Val Ser Pro Pro Pro Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg 
                245                 250                 255     


Met Gly Phe Pro Gln His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala 
            260                 265                 270         


Lys Pro Ser Phe Ser Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly 
        275                 280                 285             


Leu Thr Leu Gly Gly Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys 
    290                 295                 300                 


Glu Leu Pro Val Glu Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala 
305                 310                 315                 320 


Pro His Leu Ala Arg Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe 
                325                 330                 335     


Gln Glu Ile Pro Leu Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly 
            340                 345                 350         


Cys Gln Gly Glu Leu Lys Asp Gln His Val Tyr Val Cys Ala Val Cys 
        355                 360                 365             


Gln Asn Val Phe Cys Val Asp Cys Asp Val Phe Val His Asp Ser Leu 
    370                 375                 380                 


His Cys Cys Pro Gly Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
385                 390                 395                 400 


<210>  4614
<211>  6742
<212>  DNA
<213>  Homosapiens

<400>  4614
ttatatggtt tggctctgtc cgcacccaaa tctcatcttg aattgtaaca attcccatgt     60

gtcaagggtg gggccaggtg gagataactg aatcatggag gcagtttccc ccatgctgtt    120

ctcatggtag tgaataagtc tcatgaggtc tgatggtttt ataaatggat gttcccctgc    180

acatgctctc tcctgcccac catgtctgac taaattttgt atttttacta gagacgggct    240

ttcactatgt tggccaggct ggcctccaac tcctgatctc gtgatccgtc caccccgacc    300

tcccaaagtg ctaggatcat aggcataagc caccacaccc ggcctctttt ttttcttttt    360

ctttttttta tctggagact gagttttgca ctcgttgccc aggctggagt gcaatggtgc    420

gatctcagct cactgcagtc tccacctcag caggagagca ggaatcttca gtgatccacg    480

ggcaaatatg cagccattgt gggcacctgt tcctcccgcg acctttgtgc ccacgtctct    540

ccctccagta cctactgcac ggccccccac gtccgcctcc tgccattgcc agcaggtgcc    600

ttgcgcgggt acctggctgc gcttattcat ccattatggt cgctctgtca ctggtgccat    660

tatgtgctca catgcccact ccctcaggtt tagaagtcgc gttgcccggc aacagaacaa    720

tctgctggct tagcctttgg ccaagttggc agctggacga ggacgctcag agcccagctc    780

ttgagagttc aagtatccga cagttcccca ctgctcccag gagcggttac ccgggcactc    840

tgtgcccctc attcctgttt gggccaaggc cgaggacctg cgagtagggc tcagttgcct    900

ggagcccctt cagcccatcc cccagttcac tttgcttgtg ggatctcccc gttgctcctg    960

cccctggact gagtggcagg ccatcctaca aacacccgca cactcgacat cagtggtgtc   1020

aagacaactc taagaaggtt ttccgtgatc ctgcaagacc tgtgttccat cctggtgatt   1080

ctgtcttcaa tttcactgca caggtaccac agtaagccag tgctgtgtgc tccgagttcc   1140

agggcatccc ccagcccagc cactacactg agcacaagga ctctgtgggg cccaggagca   1200

ggtagtcacc cctttggggt ccacaacacc cggctgtccc cagacttgtg tccagggaag   1260

atagtgttga gggccctcaa ggagagcagg gcagggatgc ctgagcagga caaggacccc   1320

agagtccaag aaaatcctga tgatcagaga acggtccccg aggtcaccgg ggatgcacgg   1380

tctgcatttt ggcccctgcg ggacaatgga ggcccctctc cctttgtgcc caggcccggg   1440

cctctgcaga cagacctcca cgcccagagc tcagaaatca gatataacca cacatcccag   1500

acatcctgga cgagctcgag caccaaacga aatgccatct ccagctccta cagctccacg   1560

ggaggcttgc cggggctaaa gcagaggagg gggccagcct catcccgctg ccagctgacc   1620

ctcagttact caaagacagt gagtgaggac aggcctcagg ctgtctcttc gggtcacaca   1680

cggtgtgaaa agggggcaga tacatcacca gggcagacaa tcgccccaac gggtggctcc   1740

cccagatccc aggattctag gccccgtaga cgcaagattc ccctgctgcc acgcaggcga   1800

ggggagcctt tgatgctgcc acctccctta gagctggggt accgggtcac ggctgaagac   1860

ctgcacctgg aaaaagagac ggcattccag cgcatcaaca gtgcactgca cgttgaggac   1920

aaggccatcc cggactgcag accctcacag ccttcccaca ctttgtcctc acttgcaaca   1980

ggggcttcgg gtgggcctcc cgtttctaaa gcacacacta tggatgcaca gcaggacaga   2040

cccaagtccc aagactgcct ggacctagtg gcccccctag catctgctgc agaggtcccc   2100

gctacagctc ccgtgtctgg gaagaagcac agaccaccag gacccctgtt ctcctcctca   2160

gatccccttc cggccaactc ttcccactcc cgggactcag cccaggtcac ctcgatgatt   2220

cctgccccct tgacagctgc aagcagggat gccggcatga gaagaacaag ttcggctcct   2280

gcacctgccg cagcagcccc tcccccctcc acattgaacc ccacgtcggg gtcactactc   2340

aatgcagtgg atggaggccc ctcacatttc ttgtcctcag ccacagctgc agcacgtgtc   2400

cagaggtcag aagtgagata taaccagaga tcccagacct cccggaccag atcgtgcctc   2460

aaacgaaatg ccagctccag ctcccacagc tctacggaag gcctccaaga agtaaagcgg   2520

aggagggggc cagcctcatc ccactgccag ctggcccaca gttcctcaaa cacagtgagt   2580

gaggatggac ctcaggctgt ctcttcgggt caccgctgtg aaaacaaggc aggtacagca   2640

ccagggcaga cactcgcccc caggggtggc tcccccagat cccaggcctc taggccccac   2700

atcaacagtg cactgcacgt tgaggacaag gccatctcgg actgcagacc ctcacggcct   2760

tcccacactt tgtcctcact tgcaacaggg gcttcgggtg ggcctcccgt ttctaaagca   2820

cccactatgg atgcacagca ggacagaccc aagtcccaag actgcctggg cctagtggcc   2880

cccctagcat ctgctgcaga ggtccctgct acagctcccg tgtctgggaa gaagcacaga   2940

ccaccaggac ccctgttctc ctcctcagat ccccttcctg ccacctcttc ccactcccgg   3000

gactcagccc aggtcacctc gctgattcct gccaccttca cagctgcaag cagggatgcc   3060

ggcatgagaa gaacaaggtc ggctcctgca gctaccgcag cagcccctcc cccatccaca   3120

ttgaacaaca cgtcggggtc actactcaat gcagtggatg gaggcccctc acatttcttg   3180

gcctcagcca cagctgcagc acgtgcccag aggtcagaag tgagatataa ccagagatcc   3240

cagacctccc ggaccagatc ctgcctcaaa cgaaatgcca gctccagctc cagctcccac   3300

agctctacgg aaggcctcca ggaactaaag cggaggaggg ggccagcctc atcctactgc   3360

cagctggccc acagttcccc aaacacagtg agtgaggacg gacctcaggc tgtctcttcg   3420

ggtcaccgct gtgaaaacaa ggcaggtaca gcaccagggc acacactcgc ccccagggga   3480

ggctccccca gatcccaggc ctctaggccc cacatcaaca gtgcactgca cgttgaggac   3540

aaggccatct cggactgcag accctcacgg ccttcccaca ctttgtcctc acttgcaaca   3600

ggggcttccg gtgggcctcc cgtttctaaa gcacccacta tggacgcaca gcaggacaga   3660

cccaagtccc aagactgcct gggcctagtg gcccccctag catctgctgc agaggtcccc   3720

tctacagctc ccgtgtctgg gaagaagcac agaccaccag gacccctgtt ctcctcctca   3780

gatccccttc ctgccacctc ttcccactcc cgggactcag cccaggtcac ctcgctgatt   3840

cctgccacct tcacagctgc aagcagggat gccggcatga gaagaacaag gcctggcacc   3900

tcggctcctg cagctgccgc agcagcccct cccccctcca cattgaaccc cacgtcgggg   3960

tcgctactca atgcagtgga tggaggcccc gcacatttct tgggctcagc cacagctgca   4020

gcacgtgccc agaggtcaga agtgagatat aaccagagat cccagacctc ccggaccaga   4080

tcgtgcctca aacgaaatgc cagctccagc tcccacagct ctacggaagg cctccacgaa   4140

gtaaagcgga ggagggggcc agcctcatcc cactgccagc tggcccacag ttcctcagtg   4200

agtgaggacg gacctcaggc tgtctcttcg ggtcaccgct gtgaaaacaa ggcaggtaca   4260

gcaccagggc agacacttgc ccccaggggt ggctccccca gatcccaggc ctctaggccc   4320

cgcatcaaca ctgcactgca cgttgaggac aaggccatct cggactgcag accctcacgg   4380

ccttcccaca ctttgtcctc acttgcaaca ggggcttcgg gtgggcctcc cgtttctaaa   4440

gcacccacta tggatgcaca gcaggacaga cccaagtccc aagactgcct gggcctactg   4500

gcccccctag catctgctgc agaggtctcc tctacagctc ccgtgtctgg gaagaagcac   4560

agaccaccag gacccctgtt ctcctcctca gatccccttc ctgccacctc ttcccactcc   4620

ggggactcag cccaggacac ctcgctgatt cctgccccct tcacacctgc aagcagggat   4680

gccggcatca gaagaatgtt tcgtgttcga aattgtttga ggggtttggg tttatttttg   4740

ttggtttttt cttttttttt tttgcttacg tgggcatcct tcagctttta ataatctgaa   4800

aaattctatt tacccattgt caatgtgtat aaattaatct cagtcaattt tatacaataa   4860

aaggtgaact tttatccatc aaacaataat ttaacaaaaa atgtaccgga agaagaatgt   4920

tcattacaaa tataggaaac ataaatatta ccaaatattg gcaagcacta aaatgttcag   4980

aaatataagt ctattacagt tatagctctc tcaagcaaaa aaacagcaga gaaaaactta   5040

gtttacctga ggggctattt atttacttag ggatttgtta aaaggtcaaa tggggtcaca   5100

cagaatacta agaagagctg ttcatccagg cctcactaag aactcttctt catgcagtag   5160

ctatatggta atatgacaac tgctcctacg acccaaagag gaactacagc aactactctt   5220

tagcatctgt tgctcccaac tctgctttgc aattatatga ctcaagcatt ctggctccgt   5280

taactattac tgctgttact cccaagtaaa ttccctctaa aaaataaaaa tttttaaagc   5340

tgtaatttaa gctctctgct gcctcatgac ttcaattcca tcagagttac gcattgtttc   5400

ctctgtacat ctttgctctg cttccattgc taattcccta gaaaagtgtt gtatattcaa   5460

agttccaaag aaacagaata tccaagacat caccaatcat ccaaaacata gtgtaggagg   5520

ccacagttaa gagaagcaag accattagct ctttttatag gctcgagaac aacaggatgc   5580

tttggtcctg tatcagcagg acgctttttg ggtagatcct actgccaccc tactatcggg   5640

tagatcctac tgtcacccta gctatgggca catgtcagag tcccatgtaa taaaggagac   5700

aaaaggaaac caccacgagt ataaactaag aaaagtactc caaggtttct aagaatggag   5760

ctgtataact cactttgccc cgtttgttac ttctccacgg tacttaccac cacctattac   5820

atacattttg tttatagtca gtcttccccc attagaatga aagttccgtg aggataggac   5880

tatacagtca gccctcagta tccatggggg actggtttca ggatctcctg agggtaacaa   5940

aggatactca agtccctgat ataaaatgac atagtatttg cacatcacct ttgcacatcc   6000

tcccatatac ttcatatcaa ctctagatca ctcataatat ccgatgtaaa tgtcatgcaa   6060

atagttattg tactatattg tgtaaggaat aaggacaaga aaaaagtctg tacatgttca   6120

gtacagacgc aatttttttt tccaatattt ccaatccttg gttgccttaa cggatgtaga   6180

acccaggaat aagttctggt gtcctattgc atagtaggat gagtatagtt aacaataaca   6240

tattatatat ttgaaaatag ccagaagagt agattttgaa ttttctccct acagaaaaat   6300

cattatgcaa attaccctga tttgatcatt acacattgag tacatgtatt aaaacatcac   6360

attctacccc atatatatgt acagttatta tgtgtccata aaaatttaat gtcaatgtgt   6420

gaaataaaat gaaaaaataa aaatttttaa agctgtaatt atctccatct ggtaggaata   6480

tatacaatct gaaataaaaa atatatttgt aattgttagg acaaaataga ttatacatta   6540

agtctgcaaa ttataaatta taaaattctc acagaacctg aaaaattatt gatactgtta   6600

aatatttaaa aagctgtcct tggagagaaa gaaacctatc agatttacat caacaagtgt   6660

aatatgtcag cctattacca tctgctacag actgcatgtt tgtgttccct caaaattcat   6720

atgataggcc cggcgcggtg gc                                            6742


<210>  4615
<211>  1164
<212>  PRT
<213>  Homosapiens

<400>  4615

Met Pro Glu Gln Asp Lys Asp Pro Arg Val Gln Glu Asn Pro Asp Asp 
1               5                   10                  15      


Gln Arg Thr Val Pro Glu Val Thr Gly Asp Ala Arg Ser Ala Phe Trp 
            20                  25                  30          


Pro Leu Arg Asp Asn Gly Gly Pro Ser Pro Phe Val Pro Arg Pro Gly 
        35                  40                  45              


Pro Leu Gln Thr Asp Leu His Ala Gln Ser Ser Glu Ile Arg Tyr Asn 
    50                  55                  60                  


His Thr Ser Gln Thr Ser Trp Thr Ser Ser Ser Thr Lys Arg Asn Ala 
65                  70                  75                  80  


Ile Ser Ser Ser Tyr Ser Ser Thr Gly Gly Leu Pro Gly Leu Lys Gln 
                85                  90                  95      


Arg Arg Gly Pro Ala Ser Ser Arg Cys Gln Leu Thr Leu Ser Tyr Ser 
            100                 105                 110         


Lys Thr Val Ser Glu Asp Arg Pro Gln Ala Val Ser Ser Gly His Thr 
        115                 120                 125             


Arg Cys Glu Lys Gly Ala Asp Thr Ser Pro Gly Gln Thr Ile Ala Pro 
    130                 135                 140                 


Thr Gly Gly Ser Pro Arg Ser Gln Asp Ser Arg Pro Arg Arg Arg Lys 
145                 150                 155                 160 


Ile Pro Leu Leu Pro Arg Arg Arg Gly Glu Pro Leu Met Leu Pro Pro 
                165                 170                 175     


Pro Leu Glu Leu Gly Tyr Arg Val Thr Ala Glu Asp Leu His Leu Glu 
            180                 185                 190         


Lys Glu Thr Ala Phe Gln Arg Ile Asn Ser Ala Leu His Val Glu Asp 
        195                 200                 205             


Lys Ala Ile Pro Asp Cys Arg Pro Ser Gln Pro Ser His Thr Leu Ser 
    210                 215                 220                 


Ser Leu Ala Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala His 
225                 230                 235                 240 


Thr Met Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Asp 
                245                 250                 255     


Leu Val Ala Pro Leu Ala Ser Ala Ala Glu Val Pro Ala Thr Ala Pro 
            260                 265                 270         


Val Ser Gly Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser 
        275                 280                 285             


Asp Pro Leu Pro Ala Asn Ser Ser His Ser Arg Asp Ser Ala Gln Val 
    290                 295                 300                 


Thr Ser Met Ile Pro Ala Pro Leu Thr Ala Ala Ser Arg Asp Ala Gly 
305                 310                 315                 320 


Met Arg Arg Thr Ser Ser Ala Pro Ala Pro Ala Ala Ala Ala Pro Pro 
                325                 330                 335     


Pro Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp 
            340                 345                 350         


Gly Gly Pro Ser His Phe Leu Ser Ser Ala Thr Ala Ala Ala Arg Val 
        355                 360                 365             


Gln Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr 
    370                 375                 380                 


Arg Ser Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr 
385                 390                 395                 400 


Glu Gly Leu Gln Glu Val Lys Arg Arg Arg Gly Pro Ala Ser Ser His 
                405                 410                 415     


Cys Gln Leu Ala His Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro 
            420                 425                 430         


Gln Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala 
        435                 440                 445             


Pro Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala 
    450                 455                 460                 


Ser Arg Pro His Ile Asn Ser Ala Leu His Val Glu Asp Lys Ala Ile 
465                 470                 475                 480 


Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala 
                485                 490                 495     


Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp 
            500                 505                 510         


Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly Leu Val Ala 
        515                 520                 525             


Pro Leu Ala Ser Ala Ala Glu Val Pro Ala Thr Ala Pro Val Ser Gly 
    530                 535                 540                 


Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu 
545                 550                 555                 560 


Pro Ala Thr Ser Ser His Ser Arg Asp Ser Ala Gln Val Thr Ser Leu 
                565                 570                 575     


Ile Pro Ala Thr Phe Thr Ala Ala Ser Arg Asp Ala Gly Met Arg Arg 
            580                 585                 590         


Thr Arg Ser Ala Pro Ala Ala Thr Ala Ala Ala Pro Pro Pro Ser Thr 
        595                 600                 605             


Leu Asn Asn Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Gly Gly Pro 
    610                 615                 620                 


Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala Gln Arg Ser 
625                 630                 635                 640 


Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg Ser Cys 
                645                 650                 655     


Leu Lys Arg Asn Ala Ser Ser Ser Ser Ser Ser His Ser Ser Thr Glu 
            660                 665                 670         


Gly Leu Gln Glu Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser Tyr Cys 
        675                 680                 685             


Gln Leu Ala His Ser Ser Pro Asn Thr Val Ser Glu Asp Gly Pro Gln 
    690                 695                 700                 


Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala Pro 
705                 710                 715                 720 


Gly His Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala Ser 
                725                 730                 735     


Arg Pro His Ile Asn Ser Ala Leu His Val Glu Asp Lys Ala Ile Ser 
            740                 745                 750         


Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala Thr 
        755                 760                 765             


Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp Ala 
    770                 775                 780                 


Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly Leu Val Ala Pro 
785                 790                 795                 800 


Leu Ala Ser Ala Ala Glu Val Pro Ser Thr Ala Pro Val Ser Gly Lys 
                805                 810                 815     


Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu Pro 
            820                 825                 830         


Ala Thr Ser Ser His Ser Arg Asp Ser Ala Gln Val Thr Ser Leu Ile 
        835                 840                 845             


Pro Ala Thr Phe Thr Ala Ala Ser Arg Asp Ala Gly Met Arg Arg Thr 
    850                 855                 860                 


Arg Pro Gly Thr Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro Pro 
865                 870                 875                 880 


Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Gly 
                885                 890                 895     


Gly Pro Ala His Phe Leu Gly Ser Ala Thr Ala Ala Ala Arg Ala Gln 
            900                 905                 910         


Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg 
        915                 920                 925             


Ser Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr Glu 
    930                 935                 940                 


Gly Leu His Glu Val Lys Arg Arg Arg Gly Pro Ala Ser Ser His Cys 
945                 950                 955                 960 


Gln Leu Ala His Ser Ser Ser Val Ser Glu Asp Gly Pro Gln Ala Val 
                965                 970                 975     


Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala Pro Gly Gln 
            980                 985                 990         


Thr Leu Ala Pro Arg Gly Gly Ser  Pro Arg Ser Gln Ala  Ser Arg Pro 
        995                 1000                 1005             


Arg Ile  Asn Thr Ala Leu His  Val Glu Asp Lys Ala  Ile Ser Asp 
    1010                 1015                 1020             


Cys Arg  Pro Ser Arg Pro Ser  His Thr Leu Ser Ser  Leu Ala Thr 
    1025                 1030                 1035             


Gly Ala  Ser Gly Gly Pro Pro  Val Ser Lys Ala Pro  Thr Met Asp 
    1040                 1045                 1050             


Ala Gln  Gln Asp Arg Pro Lys  Ser Gln Asp Cys Leu  Gly Leu Leu 
    1055                 1060                 1065             


Ala Pro  Leu Ala Ser Ala Ala  Glu Val Ser Ser Thr  Ala Pro Val 
    1070                 1075                 1080             


Ser Gly  Lys Lys His Arg Pro  Pro Gly Pro Leu Phe  Ser Ser Ser 
    1085                 1090                 1095             


Asp Pro  Leu Pro Ala Thr Ser  Ser His Ser Gly Asp  Ser Ala Gln 
    1100                 1105                 1110             


Asp Thr  Ser Leu Ile Pro Ala  Pro Phe Thr Pro Ala  Ser Arg Asp 
    1115                 1120                 1125             


Ala Gly  Ile Arg Arg Met Phe  Arg Val Arg Asn Cys  Leu Arg Gly 
    1130                 1135                 1140             


Leu Gly  Leu Phe Leu Leu Val  Phe Ser Phe Phe Phe  Leu Leu Thr 
    1145                 1150                 1155             


Trp Ala  Ser Phe Ser Phe 
    1160                 


<210>  4616
<211>  4873
<212>  DNA
<213>  Homosapiens

<400>  4616
gccaccgcgc cgggcctatc atatgaattt tgagggaaca caaacatgca gtctgtagca     60

gatggtaata ggctgacata ttacacttgt tgatgtaaat ctgataggtt tctttctctc    120

caaggacagc tttttaaata tttaacagta tcaataattt ttcaggttct gtgagaattt    180

tataatttat aatttgcaga cttaatgtat aatctatttt gtcctaacaa ttacaaatat    240

attttttatt tcagattgta tatattccta ccagatggag ataattacag ctttaaaaat    300

ttttattttt tcattttatt tcacacattg acattaaatt tttatggaca cataataact    360

gtacatatat atggggtaga atgtgatgtt ttaatacatg tactcaatgt gtaatgatca    420

aatcagggta atttgcataa tgatttttct gtagggagaa aattcaaaat ctactcttct    480

ggctattttc aaatatataa tatgttattg ttaactatac tcatcctact atgcaatagg    540

acaccagaac ttattcctgg gttctacatc cgttaaggca accaaggatt ggaaatattg    600

gaaaaaaaaa ttgcgtctgt actgaacatg tacagacttt tttcttgtcc ttattcctta    660

cacaatatag tacaataact atttgcatga catttacatc ggatattatg agtgatctag    720

agttgatatg aagtatatgg gaggatgtgc aaaggtgatg tgcaaatact atgtcatttt    780

atatcaggga cttgagtatc ctttgttacc ctcaggagat cctgaaacca gtcccccatg    840

gatactgagg gctgactgta tagtcctatc ctcacggaac tttcattcta atgggggaag    900

actgactata aacaaaatgt atgtaatagg tggtggtaag taccgtggag aagtaacaaa    960

cggggcaaag tgagttatac agctccattc ttagaaacct tggagtactt ttcttagttt   1020

atactcgtgg tggtttcctt ttgtctcctt tattacatgg gactctgaca tgtgcccata   1080

gctagggtga cagtaggatc tacccgatag tagggtggca gtaggatcta cccaaaaagc   1140

atcctgctga tacaggacca aagcatcctg ttgttctcga gcctataaaa agagctaatg   1200

gtcttgcttc tcttaactgt ggcctcctac actgtgtttt ggatgattgg tgatgtcttg   1260

gatattctgt ttctttggaa ctttgaatat acaacacttt actagggaat tagcaatgga   1320

agcagagcaa agatgtacag aggaaacaat gcgtaactct gatggaattg aagtcatgag   1380

gcagcagaga gcttaaatta cagctttaaa aatttttatt ttttagaggg aatttacttg   1440

ggagtaacag cagtaatagt taacggagcc agaatgcttg agtcatataa ttgcaaagca   1500

gagttgggag caacagatgc taaagagtag ttgctgtagt tcctctgtgg gtcgtaggag   1560

cagttgtcat attactatat agctactgca tgaagaagag ttcttagtga ggcctgggtg   1620

aacagctctt cttagtattc tgtgtgaccc catttgacct tttaacaaat ccctaagtaa   1680

ataaatagcc cctcaggaaa actaagtttt tctctgctgt ttttttgctt gagagagcta   1740

taactgtaat agacttatat ttctgaacat tttagtgctt gccaatattt ggtaatattt   1800

atgtttccta tatttgtaat gaacattctt cttccggtac attttttgtt aaattattgt   1860

ttgatggata aaagttcacc ttttattgta taaaattgac tgagattaat ttatacacat   1920

tgacaatggg taaatagaat ttttcagatt attaaaagct gaaggatgcc cacgtaagca   1980

aaaaaaaaaa aagaaaaaac caacaaaaat aaacccaaac ccctcaaaca atttcgaaca   2040

cgaaacattc ttctgatgcc ggcatccctg cttgcaggtg tgaagggggc aggaatcagc   2100

gaggtgtcct gggctgagtc cccggagtgg gaagaggtgg caggaagggg atctgaggag   2160

gagaacaggg gtcctggtgg tctgtgcttc ttcccagaca cgggagctgt agaggagacc   2220

tctgcagcag atgctagggg ggccagtagg cccaggcagt cttgggactt gggtctgtcc   2280

tgctgtgcat ccatagtggg tgctttagaa acgggaggcc cacccgaagc ccctgttgca   2340

agtgaggaca aagtgtggga aggccgtgag ggtctgcagt ccgggatggc cttgtcctca   2400

acgtgcagtg cactgttgat gcgctggaat gccgtctctt tttccaggtg caggtcttca   2460

gccgtgaccc ggtaccccag ctctaaggga ggtggcagca tcaaaggctc ccctcgcctg   2520

cgtggcagca ggggaatctt gcgtctacgg ggcctagagt cctgggatct gggggagcca   2580

cccgttgggg cgattgtctg ccctggtgct gtatctgccc ccttttcaca ccgtgtgtga   2640

cccgaagaga cagcctgagg cctgtcctca ctcactgtct ttgagtaact gagggtcagc   2700

tggcagcggg atgaggctgg ccccctcctc tgctttagcc ccggcaagcc tcccgtggag   2760

ctgtaggagc tggagatggc atttcgtttg gtgttcgagc tcgtccagga tgtctgggat   2820

gtgtggttat atctgatttc tgagctctgg gcgtggaggt ctgtctgcag aggcccgggc   2880

ctgggcacaa agggagaggg gcctccattg tcccgcaggg gccaaaatgc agaccgtgca   2940

tccccggtga cctcggggac cgttctctga tcatcaggat tttcttggac tctggggtcc   3000

ttgtcctgct caggcatccc tgccccgctc tccttgaggg ccctcaacac tatcttccct   3060

ggacacaagt ctggggacag ccgggtgttg tggaccccaa aggggtgact acctgctcct   3120

gggccccaca gagtccttgt gctcagtgta gtggctgagc tgggggatgc cctggaactc   3180

ggagcacaca gcactggctt actgtggtac ctgtgcagtg aaattgaaga cagaatcacc   3240

aggatggaac acaggtcttg caggatcact tgaaaccttc ttagagttgt cttgacacca   3300

gtgatgtcga gtgtccgggt gtttgtagga tggcctgcca ctcagtccag gggcaggagc   3360

aacggggaga tcccacaagc aaagtgaact gggggatggg ctgaaggggc tccaggcaac   3420

tgagccctac tcgcaggtcc tcggccttgg cccaaacagg aatgaggggc acagagtgcc   3480

cgggtaaccg ctcctgggag cagtggggaa ctgtcggata cttgaactct caagagctgg   3540

gctctgagcg tcctcgtcca gctgccaact tggccaaagg ctaagccagc agattgttct   3600

gttgccgggc aacgcgactt ctaaacctga gggagtgggc atgtgagcac ataatggcac   3660

cagtgacaga gcgaccataa tggatgaata agcgcagcca gggctggtga attaccagat   3720

ctccgtcaag tgcagtaacc agttcaagtt ggaagtgtgt cttttgaatg cagaaaacaa   3780

agtcgtggac aaccaggctg ggacccaggg ccagctgaag gtgctgggtg ccaacctctg   3840

gtggccgtac ctgatgcacg aacaccccgc ctacctgtac tcgtgggagg atggtgattg   3900

ctcacaccaa agccttggac ccctcccagc ctgtgacctt tgggaccaac tccacctacg   3960

cagcagacaa gggggctctg tatgtggatg tgatccgtgt gaacagctac tactcttggt   4020

atcgcaacta cgggcacctg gagttgattc ggctgcagct ggccgcccag tttgagaatt   4080

ggtgtaagac atcacaatcc cattattcag agcgcgtatg gagtggaaac gcttgtaggg   4140

tttcaccagg taagcggtgt tgaactttct gcttgtgtat tctctctggg cagagatgcc   4200

acttgcctcc cccaccatgc catctctgaa gaatattaca gaccattttg gagcatggtg   4260

aataagaaat tttcacctta ggagttcagt tgaatagtca tttttatatt tgtgactgca   4320

agtcactctt aggggctgta cttccttagt actggtagca ttattatcca atggactttt   4380

atagctttca ttaggttttc ttttgttttt gttctttaaa gaacgtttta cttatcttag   4440

tatttcattt ttcatctata ttatgaggca gtaagagtct tctgtttttc caaagttgag   4500

actgctttat atttatttcg tattgtctac agctgtagtg ttcaatacat tagccactag   4560

ccacatgtgg ttatttaaat aagataaaat aaaaattggc cgggcgtggt ggctcacgcc   4620

ggtaatccca gcactttggg aggccgaggc gggcagatca ttaggtcagg agatcgagac   4680

catccttact aagacggtga acccccatct ctattaaaaa tacaaaaaaa ttagccgggc   4740

gtggtggcgg gcgcctgcag tcccagctac tcaggaggct gaggcaggag aatggcgtga   4800

acctgggagg cagagtttgc agtgagccga gatggcgcca ctgcactcca gcctggggga   4860

cagagcgaga ctc                                                      4873


<210>  4617
<211>  194
<212>  PRT
<213>  Homosapiens

<400>  4617

Met Pro Ala Ser Leu Leu Ala Gly Val Lys Gly Ala Gly Ile Ser Glu 
1               5                   10                  15      


Val Ser Trp Ala Glu Ser Pro Glu Trp Glu Glu Val Ala Gly Arg Gly 
            20                  25                  30          


Ser Glu Glu Glu Asn Arg Gly Pro Gly Gly Leu Cys Phe Phe Pro Asp 
        35                  40                  45              


Thr Gly Ala Val Glu Glu Thr Ser Ala Ala Asp Ala Arg Gly Ala Ser 
    50                  55                  60                  


Arg Pro Arg Gln Ser Trp Asp Leu Gly Leu Ser Cys Cys Ala Ser Ile 
65                  70                  75                  80  


Val Gly Ala Leu Glu Thr Gly Gly Pro Pro Glu Ala Pro Val Ala Ser 
                85                  90                  95      


Glu Asp Lys Val Trp Glu Gly Arg Glu Gly Leu Gln Ser Gly Met Ala 
            100                 105                 110         


Leu Ser Ser Thr Cys Ser Ala Leu Leu Met Arg Trp Asn Ala Val Ser 
        115                 120                 125             


Phe Ser Arg Cys Arg Ser Ser Ala Val Thr Arg Tyr Pro Ser Ser Lys 
    130                 135                 140                 


Gly Gly Gly Ser Ile Lys Gly Ser Pro Arg Leu Arg Gly Ser Arg Gly 
145                 150                 155                 160 


Ile Leu Arg Leu Arg Gly Leu Glu Ser Trp Asp Leu Gly Glu Pro Pro 
                165                 170                 175     


Val Gly Ala Ile Val Cys Pro Gly Ala Val Ser Ala Pro Phe Ser His 
            180                 185                 190         


Arg Val 
        


<210>  4618
<211>  1379
<212>  DNA
<213>  Homosapiens

<400>  4618
tgctacgcgg cacccggtcc cgtcaaccgc ccaacggctg aggagtgcgg cagcgcgcca     60

gagactggcg ggcagctccg cccgcggccg ggatgcacta ggcaaagcca gctgggctcc    120

tgagtccggt gggtacttgg agaacttact acgtctagct ggaggattgt aaatgcacca    180

atcagcatgc tgtgtctagc tcaagaactc aagctccatg aggagatgtt tcattgtcga    240

gagcagtcat gatggcctgc actccacaca atgcaacaga gtgaaagagc aggttctgct    300

tctttggtgt agtcctgaag cttcctaaga aacttcacat caggtgatgg ataggagcaa    360

ccctgtaaaa ccagccttag actatttttc aaacagatgg tgattgctca caccaaagcc    420

ttggacccct cccagcctgt gacctttggg accaactcca cctacgcagc agacaagggg    480

gctctgtatg tggatgtgat ccgtgtgaac agctactact cttggtatcg caactacggg    540

cacctggagt tgattcggct gcagctggcc gcccagtttg agaattggtg taagacatca    600

caatcccatt attcagagcg cgtatggagt ggaaacgctt gtagggtttc accaggtaag    660

cggtgttgaa ctttctgctt gtgtattctc tctgggcaga gatgccactt gcctccccca    720

ccatgccatc tctgaagaat attacagacc attttggagc atggtgaata agaaattttc    780

accttaggag ttcagttgaa tagtcatttt tatatttgtg actgcaagtc actcttaggg    840

gctgtacttc cttagtactg gtagcattat tatccaatgg acttttatag ctttcattag    900

gttttctttt gtttttgttc tttaaagaac gttttactta tcttagtatt tcatttttca    960

tctatattat gaggcagtaa gagtcttctg tttttccaaa gttgagactg ctttatattt   1020

atttcgtatt gtctacagct gtagtgttca atacattagc cactagccac atgtggttat   1080

ttaaataaga taaaataaaa attggccggg cgtggtggct cacgccggta atcccagcac   1140

tttgggaggc cgaggcgggc agatcattag gtcaggagat cgagaccatc cttactaaga   1200

cggtgaaccc ccatctctat taaaaataca aaaaaattag ccgggcgtgg tggcgggcgc   1260

ctgcagtccc agctactcag gaggctgagg caggagaatg gcgtgaacct gggaggcaga   1320

gtttgcagtg agccgagatg gcgccactgc actccagcct gggggacaga gcgagactc    1379


<210>  4619
<211>  21
<212>  PRT
<213>  Homosapiens

<400>  4619

Met Leu Cys Leu Ala Gln Glu Leu Lys Leu His Glu Glu Met Phe His 
1               5                   10                  15      


Cys Arg Glu Gln Ser 
            20      


<210>  4620
<211>  3490
<212>  DNA
<213>  Homosapiens

<400>  4620
gagtatcctt tgttaccctc aggagatcct gaaaccagtc ccccatggat actgagggct     60

gactgtatag tcctatcctc acggaacttt cattctaatg ggggaagact gactataaac    120

aaaatgtatg taataggtgg tggtaagtac cgtggagaag taacaaacgg ggcaaagtga    180

gttatacagc tccattctta gaaaccttgg agtacttttc ttagtttata ctcgtggtgg    240

tttccttttg tctcctttat tacatgggac tctgacatgt gcccatagct agggtgacag    300

taggatctac ccgatacatc ctgctgatac aggaccaaag catcctgttg ttctcgagcc    360

tataaaaaga gctaatggtc ttgcttctct taactgtggc ctcctacact gtgttttgga    420

tgattggtga tgtcttggat attctgtttc tttggaactt tgaatataca acactttact    480

agggaattag caatggaagc agagcaaaga tgtacagagg aaacaatgcg taactctgat    540

ggaattgaag tcatgaggca gcagagagct taaattacag ctttaaaaat ttttattttt    600

tagagggaat ttacttggga gtaacagcag taatagttaa cggagccaga atgcttgagt    660

catataattg caaagcagag ttgggagcaa cagatgctaa agagtagttg ctgtagttcc    720

tctgtgggtc gtaggagcag ttgtcatatt actatatagc tactgcatga agaagagttc    780

ttagtgaggc ctgggtgaac agctcttctt agtattctgt gtgaccccat ttgacctttt    840

aacaaatccc taagtaaata aatagcccct caggaaaact aagtttttct ctgctgtttt    900

tttgcttgag agagctataa ctgtaataga cttatatttc tgaacatttt agtgcttgcc    960

aatatttggt aatatttatg tttcctatat ttgtaatgaa cattcttctt ccggtacatt   1020

ttttgttaaa ttattgtttg atggataaaa gttcaccttt tattgtataa aattgactga   1080

gattaattta tacacattga caatgggtaa atagaatttt tcagattatt aaaagctgaa   1140

ggatgcccac gtaagcaaaa aaaaaaaaag aaaaaaccaa caaaaataaa cccaaacccc   1200

tcaaacaatt tcgaacacga aacattcttc tgatgccggc atccctgctt gcaggtgtga   1260

agggggcagg aatcagcgag gtgtcctggg ctgagtcccc ggagtgggaa gaggtggcag   1320

gaaggggatc tgaggaggag aacaggggtc ctggtggtct gtgcttcttc ccagacacgg   1380

gagctgtaga ggagacctct gcagcagatg ctaggggggc cagtaggccc aggcagtctt   1440

gggacttggg tctgtcctgc tgtgcatcca tagtgggtgc tttagaaacg ggaggcccac   1500

ccgaagcccc tgttgcaagt gaggacaaag tgtgggaagg ccgtgagggt ctgcagtccg   1560

ggatggcctt gtcctcaacg tgcagtgcac tgttgatgcg ctggaatgcc gtctcttttt   1620

ccaggtgcag gtcttcagcc gtgacccggt accccagctc taagggaggt ggcagcatca   1680

aaggctcccc tcgcctgcgt ggcagcaggg gaatcttgcg tctacggggc ctagagtcct   1740

gggatctggg ggagccaccc gttggggcga ttgtctgccc tggtgctgta tctgccccct   1800

tttcacaccg tgtgtgaccc gaagagacag cctgaggcct gtcctcactc actgtctttg   1860

agtaactgag ggtcagctgg cagcgggatg aggctggccc cctcctctgc tttagccccg   1920

gcaagcctcc cgtggagctg taggagctgg agatggcatt tcgtttggtg ttcgagctcg   1980

tccaggatgt ctgggatgtg tggttatatc tgatttctga gctctgggcg tggaggtctg   2040

tctgcagagg cccgggcctg ggcacaaagg gagaggggcc tccattgtcc cgcaggggcc   2100

aaaatgcaga ccgtgcatcc ccggtgacct cggggaccgt tctctgatca tcaggatttt   2160

cttggactct ggggtccttg tcctgctcag gcatccctgc cccgctctcc ttgagggccc   2220

tcaacactat cttccctgga cacaagtctg gggacagccg ggtgttgtgg accccaaagg   2280

ggtgactacc tgctcctggg ccccacagag tccttgtgct cagtgtagtg gctgagctgg   2340

gggatgccct ggaactcgga gcacacagca ctggcttact gtggtacctg tgcagtgaaa   2400

ttgaagacag aatcaccagg atggaacaca ggtcttgcag gatcacttga aaccttctta   2460

gagttgtctt gacaccagtg atgtcgagtg tccgggtgtt tgtaggatgg cctgccactc   2520

agtccagggg caggagcaac ggggagatcc cacaagcaaa gtgaactggg ggatgggctg   2580

aaggggctcc aggcaactga gccctactcg caggtcctcg gccttggccc aaacaggaat   2640

gaggggcaca gagtgcccgg gtaaccgctc ctgggagcag tggggaactg tcggatactt   2700

gaactctcaa gagctgggct ctgagcgtcc tcgtccagct gccaacttgg ccaaaggcta   2760

agccagcaga ttgttctgtt gccgggcaac gcgacttcta aacctgaggg agtgggcatg   2820

tgagcacata atggcaccag tgacagagcg accataatgg atgaataagc gcagccaggt   2880

acccgcgcaa ggcacctgct ggcaatggca ggaggcggac gtggggggtc gtgcagtagg   2940

tactggaggg agagacgtgg gcacaaaggt cgcgggagga acaggtgccc acaatggctg   3000

catatttgcc cgtggatcac tgaagattcc tgctctcctg ctgaggtgga gactgcagtg   3060

agctgagatc gcaccattgc actccagcct gggcaacgag tgcaaaactc agtctccaga   3120

taaaaaaaag aaaaagaaaa aaaagaggcc gggtgtggtg gcttatgcct atgatcctag   3180

cactttggga ggtcggggtg gacggatcac gagatcagga gttggaggcc agcctggcca   3240

acatagtgaa agcccgtctc tagtaaaaat acaaaattta gtcagacatg gtgggcagga   3300

gagagcatgt gcaggggaac atccatttat aaaaccatca gacctcatga gacttattca   3360

ctaccatgag aacagcatgg gggaaactgc ctccatgatt cagttatctc cacctggccc   3420

cacccttgac acatgggaat tgttacaatt caagatgaga tttgggtgcg gacagagcca   3480

aaccatataa                                                          3490


<210>  4621
<211>  194
<212>  PRT
<213>  Homosapiens

<400>  4621

Met Pro Ala Ser Leu Leu Ala Gly Val Lys Gly Ala Gly Ile Ser Glu 
1               5                   10                  15      


Val Ser Trp Ala Glu Ser Pro Glu Trp Glu Glu Val Ala Gly Arg Gly 
            20                  25                  30          


Ser Glu Glu Glu Asn Arg Gly Pro Gly Gly Leu Cys Phe Phe Pro Asp 
        35                  40                  45              


Thr Gly Ala Val Glu Glu Thr Ser Ala Ala Asp Ala Arg Gly Ala Ser 
    50                  55                  60                  


Arg Pro Arg Gln Ser Trp Asp Leu Gly Leu Ser Cys Cys Ala Ser Ile 
65                  70                  75                  80  


Val Gly Ala Leu Glu Thr Gly Gly Pro Pro Glu Ala Pro Val Ala Ser 
                85                  90                  95      


Glu Asp Lys Val Trp Glu Gly Arg Glu Gly Leu Gln Ser Gly Met Ala 
            100                 105                 110         


Leu Ser Ser Thr Cys Ser Ala Leu Leu Met Arg Trp Asn Ala Val Ser 
        115                 120                 125             


Phe Ser Arg Cys Arg Ser Ser Ala Val Thr Arg Tyr Pro Ser Ser Lys 
    130                 135                 140                 


Gly Gly Gly Ser Ile Lys Gly Ser Pro Arg Leu Arg Gly Ser Arg Gly 
145                 150                 155                 160 


Ile Leu Arg Leu Arg Gly Leu Glu Ser Trp Asp Leu Gly Glu Pro Pro 
                165                 170                 175     


Val Gly Ala Ile Val Cys Pro Gly Ala Val Ser Ala Pro Phe Ser His 
            180                 185                 190         


Arg Val 
        


<210>  4622
<211>  4313
<212>  DNA
<213>  Homosapiens

<400>  4622
gccaccgcgc cgggcctatc atatgaattt tgagggaaca caaacatgca gtctgtagca     60

gatggtaata ggctgacata ttacacttgt tgatgtaaat ctgataggtt tctttctctc    120

caaggacagc tttttaaata tttaacagta tcaataattt ttcaggttct gtgagaattt    180

tataatttat aatttgcaga cttaatgtat aatctatttt gtcctaacaa ttacaaatat    240

attttttatt tcagattgta tatattccta ccagatggag ataattacag ctttaaaaat    300

ttttattttt tcattttatt tcacacattg acattaaatt tttatggaca cataataact    360

gtacatatat atggggtaga atgtgatgtt ttaatacatg tactcaatgt gtaatgatca    420

aatcagggta atttgcataa tgatttttct gtagggagaa aattcaaaat ctactcttct    480

ggctattttc aaatatataa tatgttattg ttaactatac tcatcctact atgcaatagg    540

acaccagaac ttattcctgg gttctacatc cgttaaggca accaaggatt ggaaatattg    600

gaaaaaaaaa ttgcgtctgt actgaacatg tacagacttt tttcttgtcc ttattcctta    660

cacaatatag tacaataact atttgcatga catttacatc ggatattatg agtgatctag    720

agttgatatg aagtatatgg gaggatgtgc aaaggtgatg tgcaaatact atgtcatttt    780

atatcaggga cttgagtatc ctttgttacc ctcaggagat cctgaaacca gtcccccatg    840

gatactgagg gctgactgta tagtcctatc ctcacggaac tttcattcta atgggggaag    900

actgactata aacaaaatgt atgtaatagg tggtggtaag taccgtggag aagtaacaaa    960

cggggcaaag tgagttatac agctccattc ttagaaacct tggagtactt ttcttagttt   1020

atactcgtgg tggtttcctt ttgtctcctt tattacatgg gactctgaca tgtgcccata   1080

gctagggtga cagtaggatc tacccgatag tagggtggca gtaggatcta cccaaaaagc   1140

atcctgctga tacaggacca aagcatcctg ttgttctcga gcctataaaa agagctaatg   1200

gtcttgcttc tcttaactgt ggcctcctac actgtgtttt ggatgattgg tgatgtcttg   1260

gatattctgt ttctttggaa ctttgaatat acaacacttt actagggaat tagcaatgga   1320

agcagagcaa agatgtacag aggaaacaat gcgtaactct gatggaattg aagtcatgag   1380

gcagcagaga gcttaaatta cagctttaaa aatttttatt ttttagaggg aatttacttg   1440

ggagtaacag cagtaatagt taacggagcc agaatgcttg agtcatataa ttgcaaagca   1500

gagttgggag caacagatgc taaagagtag ttgctgtagt tcctctgtgg gtcgtaggag   1560

cagttgtcat attactatat agctactgca tgaagaagag ttcttagtga ggcctgggtg   1620

aacagctctt cttagtattc tgtgtgaccc catttgacct tttaacaaat ccctaagtaa   1680

ataaatagcc cctcaggaaa actaagtttt tctctgctgt ttttttgctt gagagagcta   1740

taactgtaat agacttatat ttctgaacat tttagtgctt gccaatattt ggtaatattt   1800

atgtttccta tatttgtaat gaacattctt cttccggtac attttttgtt aaattattgt   1860

ttgatggata aaagttcacc ttttattgta taaaattgac tgagattaat ttatacacat   1920

tgacaatggg taaatagaat ttttcagatt attaaaagct gaaggatgcc cacgtaagca   1980

aaaaaaaaaa aagaaaaaac caacaaaaat aaacccaaac ccctcaaaca atttcgaaca   2040

cgaaacattc ttctgatgcc ggcatccctg cttgcaggtg tgaagggggc aggaatcagc   2100

gaggtgtcct gggctgagtc cccggagtgg gaagaggtgg caggaagggg atctgaggag   2160

gagaacaggg gtcctggtgg tctgtgcttc ttcccagaca cgggagctgt agaggagacc   2220

tctgcagcag atgctagggg ggccagtagg cccaggcagt cttgggactt gggtctgtcc   2280

tgctgtgcat ccatagtggg tgctttagaa acgggaggcc cacccgaagc ccctgttgca   2340

agtgaggaca aagtgtggga aggccgtgag ggtctgcagt ccgggatggc cttgtcctca   2400

acgtgcagtg cactgttgat gcgctggaat gccgtctctt tttccaggtg caggtcttca   2460

gccgtgaccc ggtaccccag ctctaaggga ggtggcagca tcaaaggctc ccctcgcctg   2520

cgtggcagca ggggaatctt gcgtctacgg ggcctagagt cctgggatct gggggagcca   2580

cccgttgggg cgattgtctg ccctggtgct gtatctgccc ccttttcaca ccgtgtgtga   2640

cccgaagaga cagcctgagg cctgtcctca ctcactgtct ttgagtaact gagggtcagc   2700

tggcagcggg atgaggctgg ccccctcctc tgctttagcc ccggcaagcc tcccgtggag   2760

ctgtaggagc tggagatggc atttcgtttg gtgttcgagc tcgtccagga tgtctgggat   2820

gtgtggttat atctgatttc tgagctctgg gcgtggaggt ctgtctgcag aggcccgggc   2880

ctgggcacaa agggagaggg gcctccattg tcccgcaggg gccaaaatgc agaccgtgca   2940

tccccggtga cctcggggac cgttctctga tcatcaggat tttcttggac tctggggtcc   3000

ttgtcctgct caggcatccc tgccccgctc tccttgaggg ccctcaacac tatcttccct   3060

ggacacaagt ctggggacag ccgggtgttg tggaccccaa aggggtgact acctgctcct   3120

gggccccaca gagtccttgt gctcagtgta gtggctgagc tgggggatgc cctggaactc   3180

ggagcacaca gcactggctt actgtggtac ctgtgcagtg aaattgaaga cagaatcacc   3240

aggatggaac acaggtcttg caggatcact tgaaaccttc ttagagttgt cttgacacca   3300

gtgatgtcga gtgtccgggt gtttgtagga tggcctgcca ctcagtccag gggcaggagc   3360

aacggggaga tcccacaagc aaagtgaact gggggatggg ctgaaggggc tccaggcaac   3420

tgagccctac tcgcaggtcc tcggccttgg cccaaacagg aatgaggggc acagagtgcc   3480

cgggtaaccg ctcctgggag cagtggggaa ctgtcggata cttgaactct caagagctgg   3540

gctctgagcg tcctcgtcca gctgccaact tggccaaagg ctaagccagc agattgttct   3600

gttgccgggc aacgcgactt ctaaacctga gggagtgggc atgtgagcac ataatggcac   3660

cagtgacaga gcgaccataa tggatgaata agcgcagcca ggtacccgcg caaggcacct   3720

gctggcaatg gcaggaggcg gacgtggggg gtcgtgcagt aggtactgga gggagagacg   3780

tgggcacaaa ggtcgcggga ggaacaggtg cccacaatgg ctgcatattt gcccgtggat   3840

cactgaagat tcctgctctc ctgctgaggt ggagactgca gtgagctgag atcgcaccat   3900

tgcactccag cctgggcaac gagtgcaaaa ctcagtctcc agataaaaaa aagaaaaaga   3960

aaaaaaagag gccgggtgtg gtggcttatg cctatgatcc tagcactttg ggaggtcggg   4020

gtggacggat cacgagatca ggagttggag gccagcctgg ccaacatagt gaaagcccgt   4080

ctctagtaaa aatacaaaat ttagtcagac atggtgggca ggagagagca tgtgcagggg   4140

aacatccatt tataaaacca tcagacctca tgagacttat tcactaccat gagaacagca   4200

tgggggaaac tgcctccatg attcagttat ctccacctgg ccccaccctt gacacatggg   4260

aattgttaca attcaagatg agatttgggt gcggacagag ccaaaccata taa          4313


<210>  4623
<211>  194
<212>  PRT
<213>  Homosapiens

<400>  4623

Met Pro Ala Ser Leu Leu Ala Gly Val Lys Gly Ala Gly Ile Ser Glu 
1               5                   10                  15      


Val Ser Trp Ala Glu Ser Pro Glu Trp Glu Glu Val Ala Gly Arg Gly 
            20                  25                  30          


Ser Glu Glu Glu Asn Arg Gly Pro Gly Gly Leu Cys Phe Phe Pro Asp 
        35                  40                  45              


Thr Gly Ala Val Glu Glu Thr Ser Ala Ala Asp Ala Arg Gly Ala Ser 
    50                  55                  60                  


Arg Pro Arg Gln Ser Trp Asp Leu Gly Leu Ser Cys Cys Ala Ser Ile 
65                  70                  75                  80  


Val Gly Ala Leu Glu Thr Gly Gly Pro Pro Glu Ala Pro Val Ala Ser 
                85                  90                  95      


Glu Asp Lys Val Trp Glu Gly Arg Glu Gly Leu Gln Ser Gly Met Ala 
            100                 105                 110         


Leu Ser Ser Thr Cys Ser Ala Leu Leu Met Arg Trp Asn Ala Val Ser 
        115                 120                 125             


Phe Ser Arg Cys Arg Ser Ser Ala Val Thr Arg Tyr Pro Ser Ser Lys 
    130                 135                 140                 


Gly Gly Gly Ser Ile Lys Gly Ser Pro Arg Leu Arg Gly Ser Arg Gly 
145                 150                 155                 160 


Ile Leu Arg Leu Arg Gly Leu Glu Ser Trp Asp Leu Gly Glu Pro Pro 
                165                 170                 175     


Val Gly Ala Ile Val Cys Pro Gly Ala Val Ser Ala Pro Phe Ser His 
            180                 185                 190         


Arg Val 
        


<210>  4624
<211>  3616
<212>  DNA
<213>  Homosapiens

<400>  4624
tgctacgcgg cacccggtcc cgtcaaccgc ccaacggctg aggagtgcgg cagcgcgcca     60

gagactggcg ggcagctccg cccgcggccg ggatgcacta ggcaaagcca gctgggctcc    120

tgagtccggt gggtacttgg agaacttact acgtctagct ggaggattgt aaatgcacca    180

atcagcatgc tgtgtctagc tcaagaactc aagctccatg aggagatgtt tcattgtcga    240

gagcagtcat gatggcctgc actccacaca atgcaacaga gtgaaagagc aggttctgct    300

tctttggtgt agtcctgaag cttcctaaga aacttcacat caggtgatgg ataggagcaa    360

ccctgtaaaa ccagccttag actatttttc aaacagatgg tgattgctca caccaaagcc    420

ttggacccct cccagcctgt gacctttgtg accaactcca cctacgcagc agacaagggg    480

gctctgtatg tggatgtgat ccgtgtgaac agctactact cttggtatcg caactacggg    540

cacctggagt tgattcagct gcagctggcc gcccagtttg agaattggtg taagacatca    600

caatcccatt attcagagcg cgtatggagt ggaaacgctt gtaaggcttc accaggatcc    660

acctctgatg ttcagtgaag aggaccggaa aagtctgcta gagcagtacc atctgggtct    720

ggatcaaaaa cgcagaaaat acgtggttgg agagctcatc tggaattttg ccgatttcat    780

gactaaccag tccaaggatg aaggaaaaac tggacctcat tatggattta cttttgggat    840

acactcatta ttccagagga gggtaaaagg ctgagaagct taagatggag ctggcttgaa    900

atcctcttgt ttatggcagt acatatcggt tatgattcaa aaaatatagc ccatttccaa    960

aaacctgcaa caaagagata ctttctcagg tgtcagtttc ttggtcggga atgaaaatag   1020

tgccaacctg tgataccttc actctaattt tactttctga ggaagttttc tgtaatagtt   1080

atttggtgat aattattaat actggtgaga aaatcaatgt aaaagaggag aaataaccca   1140

cacaaccaca tacaactagg aaatgataga tggatctgaa aaaaaggata tgcactctta   1200

acaagttcaa cacccaagta ctattgcaag taccagctgt atttcatgga aaaaaaaaaa   1260

agaataactc aaaaggcaga acgaagagcc tagaggtcag agatgagagg catgaataat   1320

tattcacagg cgttgaatat aatcaaatga cttgcaacat ttaccactgg gattttaaaa   1380

tgtggtggac caatcattct tttagtctgt gcattttccc atttttttca acaggaatgt   1440

ctagagacat tattcctgtt ttgccactgt atttttggtg aatgtgtagt aagtaactgg   1500

cctctttagt atcacaaagc tggatgaaga aaatgtggta catatacacc atgaaatact   1560

atgccgccac aaaaaggaaa tgagatcatg tcctctgcag ggacatggat gaagctggaa   1620

gccattatcc ttagcaaagt aacgcaggaa cagaaaacca aacaccacat gttgtctctt   1680

agaagtggga gctgaacggt aagaacacat ggacacaggg tggagaacaa tacacactgg   1740

ggcttgatgg ggggtggagg ggagggatgg ggagcattag aaaaaataac taatgcatgc   1800

tgggcttaat acctatgtga tgggttgata ggtgcagcaa accaccctgg cacatgttta   1860

tcaatgtaac aaacctgcac atcctgcaca ggtactccaa aactaaaagt aaaaaaatct   1920

aaaagaaaaa aaaaaagaat taaacccaaa atcactaccc catctggact tgatttagat   1980

gaaaagcttc tggactttga gctgatgcta tagtgggttg aaaattttgg ggtcctcaga   2040

aggggatgag gatatattgc atgagagagc aacatgaatc attgagagcc agagtataga   2100

gagtggtagg tagactgtag gagagccctc aatgatcccg gctttcttgt attcgcgttg   2160

cacttacttg tataatatgg cagatgggat gtgatgtcac tttcaagatt aggttataaa   2220

tagactatgg cttcaatcag agggttttct ctctgtctag ctctcttttg ggtagttcat   2280

tctgaggaaa gccagctgcc acgttatgat gtaggcctgt gaggtccacg tagcaaagaa   2340

catatggaag atttctacca ccccctaact aagcctttag atcagactgc aaccccagcc   2400

aacaaggtag ctacaaactc ttgagaagcc ttgagacaga ggtactcaat agagccattc   2460

ctatgagaaa cgtaagtatc tgctgtttta caccgctaag gttttagcta atgtattatg   2520

ccataataga taagttatat acaaccttta tcaaataata aaagtaacca tcatcagtaa   2580

tgagacaaat caaaaaccat ggcccaccca atagaacata atgaggagag tacagaattg   2640

cttctgggat atttctgaca aagatgtata tgcttcattc atacatgagg aaacatcaca   2700

catactcaag atgggagagc cattctaaaa aataactagg cagaaatctt caaaaatatt   2760

aaagtcacgg aaaccaagaa aaaatatgaa cctgtttcag attaaaggaa actaaacaga   2820

cctaacattt taatacaatg tttgattttg aacttgaact ttttgttata taagacacta   2880

ttgagacaag tgctaatgct tgaatagggc tgaaggatta gattataata atacattaat   2940

gcaaatttcc tgattttaaa cattgtagtt tgattgcaca aggagaatgt ctttatgtgt   3000

ggaaaataaa tagtcaacat tctgtcttca agcttctgaa aaaactctgc ttttagggca   3060

tagatagaag tggatgataa ttcacctgtt cctctgctac taattgagct gctctctgtt   3120

tccatggctg gctcatggga tgagagaata tatctagttt tttatgtttc aatttgtctc   3180

tctatggcat ttttgtgaaa ataaggaagt gtggagactt atatatgttt ctaaattata   3240

atagttcatt aatgtaaagt acagacacag tcttcacttt tccttcttag accgtttaaa   3300

tatggccacg aaacaagtag tctctggttg gctgggcact gtggctcatg tccttaacac   3360

caacactttg ggaggccgag gcaggcaaat cacttgagat caggagttcg agaccagcct   3420

ggccaatgtg gcaaaacccc atctcttcta aaaatacaaa aattagttga gtgcggtggt   3480

gcacaccggt aatcccagtt actcgagaag ctgaggcagg agaatcactt gaacctggaa   3540

ggcagaggtt gcagtgagcc aagaccgcac cactacactc cagcctgggc aatagagcaa   3600

gactccatct caaaaa                                                   3616


<210>  4625
<211>  21
<212>  PRT
<213>  Homosapiens

<400>  4625

Met Leu Cys Leu Ala Gln Glu Leu Lys Leu His Glu Glu Met Phe His 
1               5                   10                  15      


Cys Arg Glu Gln Ser 
            20      


<210>  4626
<211>  6748
<212>  DNA
<213>  Homosapiens

<400>  4626
ttatatggtt tggctctgtc cgcacccaaa tctcatcttg aattgtaaca attcccatgt     60

gtcaagggtg gggccaggtg gagataactg aatcatggag gcagtttccc ccatgctgtt    120

ctcatggtag tgaataagtc tcatgaggtc tgatggtttt ataaatggat gttcccctgc    180

acatgctctc tcctgcccac catgtctgac taaattttgt atttttacta gagacgggct    240

ttcactatgt tggccaggct ggcctccaac tcctgatctc gtgatccgtc caccccgacc    300

tcccaaagtg ctaggatcat aggcataagc caccacaccc ggcctctttt ttttcttttt    360

ctttttttta tctggagact gagttttgca ctcgttgccc aggctggagt gcaatggtgc    420

gatctcagct cactgcagtc tccacctcag caggagagca ggaatcttca gtgatccacg    480

ggcaaatatg cagccattgt gggcacctgt tcctcccgcg acctttgtgc ccacgtctct    540

ccctccagta cctactgcac gaccccccac gtccgcctcc tgccattgcc agcaggtgcc    600

ttgcgcgggt acctggctgc gcttattcat ccattatggt cgctctgtca ctggtgccat    660

tatgtgctca catgcccact ccctcaggtt tagaagtcgc gttgcccggc aacagaacaa    720

tctgctggct tagcctttgg ccaagttggc agctggacga ggacgctcag agcccagctc    780

ttgagagttc aagtatccga cagttcccca ctgctcccag gagcggttac ccgggcactc    840

tgtgcccctc attcctgttt gggccaaggc cgaggacctg cgagtagggc tcagttgcct    900

ggagcccctt cagcccatcc cccagttcac tttgcttgtg ggatctcccc gttgctcctg    960

cccctggact gagtggcagg ccatcctaca aacacccgca cactcgacat cactggtgtc   1020

aagacaactc taagaaggtt ttccgtgatc ctgcaagacc tgtgttccat cctggtgatt   1080

ctgtcttcaa tttcactgca caggtaccac agtaagccag tgctgtgtgc tccgagttcc   1140

agggcatccc ccagctcagc cactacactg agcacaagga ctctgtgggg cccaggagca   1200

ggtagtcacc cctttggggt ccacaacacc cggctgtccc cagacttgtg tccagggaag   1260

atagtgttga gggccctcaa ggagagcggg gcagggatgc ctgagcagga caaggacccc   1320

agagtccaag aaaatcctga tgatcagaga acggtccccg aggtcaccgg ggatgcacgg   1380

tctgcatttt ggcccctgcg ggacaatgga ggcccctctc cctttgtgcc caggcccggg   1440

cctctgcaga cagacctcca cgcccagagc tcagaaatca gatataacca cacatcccag   1500

acatcctgga cgagctcgag caccaaacga aatgccatct ccagctccta cagctccacg   1560

ggaggcttgc cggggctaaa gcagaggagg gggccagcct catcccgctg ccagctgacc   1620

ctcagttact caaagacagt gagtgaggac aggcctcagg ctgtctcttc gggtcacaca   1680

cggtgtgaaa agggggcaga tacagcacca gggcagacaa tcgccccaac gggtggctcc   1740

cccagatccc aggactctag gccccgtaga cgcaagattc ccctgctgcc acgcaggcga   1800

ggggagcctt tgatgctgcc acctccctta gagctggggt accgggtcac ggctgaagac   1860

ctgcacctgg aaaaagagac ggcattccag cgcatcaaca gtgcactgca cgttgaggac   1920

aaggccatcc cggactgcag accctcacgg ccttcccaca ctttgtcctc acttgcaaca   1980

ggggcttcgg gtgggcctcc cgtttctaaa gcacccacta tggatgcaca gcaggacaga   2040

cccaagtccc aagactgcct gggcctagtg gcccccctag catctgctgc agaggtcccc   2100

gctacagctc ccgtgtctgg gaagaagcac agaccaccag gacccctgtt ctcctcctca   2160

gatccccttc ctgccaactc ttcccactcc cgggactcag cccaggtcac ctcgatgatt   2220

cctgccccct tcacagctgc aagcagggat gccggcatga gaagaacaag gtcggctcct   2280

gcagctgccg cagcagcccc tcccccctcc acattgaacc ccacgtcggg gtcactactc   2340

aatgcagtgg atggaggccc ctcacatttc ttggcctcag ccacagctgc agcacgtgcc   2400

cagaggtcag aagtgagata taaccagaga tcccagacct cccggaccag atcctgcctc   2460

aaacgaaatg ccagctccag ctcccacagc tctacggaag gcctccagga agtaaagcgg   2520

aggagggggc cagcctcatc ccactgccag ctggccctca gttcctcaaa cacagtgagt   2580

gaggacggac ctcaggctgt ctcttcgggt caccgctgtg aaaacaaggc aggtacagca   2640

ccagggcaga cacttgcccc caggggtggc tcccccagat cccaggcctc taggccccac   2700

atcaacactg cactgcacgt tgaggacaag gccatctcgg actgcagacc ctcacggcct   2760

tcccacactt tgtcctcact tgcaacaggg gcttcgggtg ggcctcccgt ttctaaagca   2820

cccactatgg atgcacagca ggacagaccc aagtcccaag actccctggg cctactggcc   2880

cccctagcat ctgctgcaga ggtcccctct acagctcccg tgtctgggaa gaagcacaga   2940

ccaccaggac ccctgttctc ctcctcagat ccccttcctg ccacctctta ccactcccgg   3000

gacacagcac aggtcacctc gctgattcct gccaccttca cagctgcaag cagggatgcc   3060

ggcatgagaa gaacaaggtc ggctcctgca gctgccacag cagcccctcc cccctccaca   3120

ttgaacaaca cgtcggggtc actactcaat gcagtggatg gaggcccctc acatttcttg   3180

gcctcagcca cagctgcagc acgtgcccag aggtcagaag tgagatataa ccagagatcc   3240

cagacctccc ggaccagatc ctgcctcaaa cgaaatgcca gctccagctc cagctcccac   3300

agctctacgg aaggcctcca ggaactaaag cggaggaggg ggccagcctc atcccactgc   3360

cagctggccc acagttcctc aaacacagtg agtgaggacg gacctcaggc tgtctcttcg   3420

ggtcaccgct gtgaaaacaa ggcaggtaca gcaccagggc agacactcgc ccccagggga   3480

ggctccccca gatcccaggc ctctaggccc cacatcaaca gtgcactgta cgttgaggac   3540

aaggccatct cggactgcag accctcacgg ccttcccaca ctttgtcctc acttgcaaca   3600

ggggcttcgg gtgggcctcc cgtttctaaa gcacccacta tggacgcaca gcaggacaga   3660

cccaagtccc aagactgcct gggcctagtg gcccccctag catctgctgc agaggtcccc   3720

tctacagctc ccgtgtctgg gaagaagcac agaccaccag gacccctgtt ctcctcctca   3780

gatccccttc ctgccacctc ttcccactcc cgggactcag cccaggtcac ctcgctgatt   3840

cctgccacct tcacagctgc aagcagggat gccggcatga gaagaacaag gcctggcacc   3900

tcggctcctg cagctgccgc agcagccctt cccccctcca cattgaaccc cacgtcgggg   3960

tcgctactca atgcagtgga tggaggcccc tcacatttct tggcctcagc cacagctgca   4020

gcacgtgccc agaggtcaga agtgagatat aaccagagat cccagacctc ccggaccaga   4080

tcctgcctca aacgaaatgc cagctccagc tcccacagct ctacggaagg cctccaggaa   4140

ctaaagcgga ggagggggcc agcctcatcc cactgccagc tggcccacag ttcctcaaac   4200

acagtgagtg aggacggacc tcaggctgtc tcttcgggtc accgctgtga aaacaaggca   4260

ggtacagcac cagggcagac actcgccccc aggggtggct accccagatc ccaggcctct   4320

aggccccgca tcaacagtgc actgcacgtt gaggacaagg ccatctcgga ctgcagaccc   4380

tcacggcctt cccacacttt gtcctcactt gcaacagggg cttcgggtgg gcctcccgtt   4440

tctaaagcac ccactatgga tgcacagcag gacagaccca agtcccaaga ctgcctgggc   4500

ctactggccc ccctagcatc tgctgcagag gtctcctcta cagctcccgt gtctgggaag   4560

aagcacagac caccaggacc cctgttctcc tcctcagatc cccttcctgc cacctcttcc   4620

cactccgggg actcagccca ggacacctcg ctgattcctg cccccttcac acctgcaagc   4680

agggatgccg gcatcagaag aatgtttcgt gttcgaaact gtttgagggg tttgggttta   4740

tttttgttgg ttttttcttt tttttttttg cttacgtggg catccttcag cttttaataa   4800

tctgaaaaat tctatttacc cattgtcaat gtgtataaat taatctcagt caattttata   4860

caataaaagg tgaactttta tccatcaaac aataatttaa caaaaaatgt accggaagaa   4920

gaatgttcat tacaaatata ggaaacataa atattaccaa atattggcaa gcactaaaat   4980

gttcagaaat ataagtctat tacagttata gctctctcaa gcaaaaaaac agcagagaaa   5040

aacttagttt tcctgagggg ctatttattt acttagggat ttgttaaaag gtcaaatggg   5100

gtcacacaga atactaagaa gagctgttca cccaggcctc actaagaact cttcttcatg   5160

cagtagctat atagtaatat gacaactgct cctacgaccc aaagaggaac tacagcaact   5220

actctttagc atctgttgct cccaactctg ctttgcaatt atatgactca agcattctgg   5280

ctccgttaac tattactgct gttactccca agtaaattcc ctctaaaaaa taaaaatttt   5340

taaagctgta atttaagctc tctgctgcct catgacttca attccatcag agttacgcat   5400

tgtttcctct gtacatcttt gctctgcttc cattgctaat tccctagtaa agtgttgtat   5460

attcaaagtt ccaaagaaac agaatatcca agacatcacc aatcatccaa aacacagtgt   5520

aggaggccac agttaagaga agcaacacca ttagctcttt ttataggctc gagaacaaca   5580

ggatgctttg gtcctgtatc agcaggacgc tttttgggta gatcctactg ccaccctact   5640

atcgggtaga tcctactgtc accctagcta tgggcacatg tcagagtccc atgtaataaa   5700

ggagacaaaa ggaaaccacc acgagtataa actaagaaaa gtactccaag gtttctaaga   5760

atggagctgt ataactcact ttgccccatt tgttacttct ccacggtact taccaccacc   5820

tattacatat attttgttta tagtcagtct tcccccatta gaatgaaagt tccgtgagga   5880

taggactata cagtcagccc tcagtatcca tgggggactg gtttcaggat ctcctgaggg   5940

taacaaagga tactcaagtc cctgatataa aatgacatag tatttgcaca tcacctttgc   6000

acatcctccc atatacttca tatcaactct agatcactca taatatccga tgtaaatgtc   6060

atgcaaatag ttattgtact atattgtgta aggaataagg acaagaaaaa agtctgtaca   6120

tgttcagtac agacgcaatt tttttttcca atatttccaa tccttggttg ccttaacgga   6180

tgtagaaccc aggaataagt tctggtgtcc tattgcatag taggatgagt atagttaaca   6240

ataacatatt atatatttga aaatagccag aagagtagat tttgaatttt ctccctacag   6300

aaaaatcatt atgcaaatta ccctgatttg atcattacac attgagtaca tgtattaaaa   6360

catcacattc taccccatat atatgtacag ttattatgtg tccataaaaa tttaatgtca   6420

atgtgtgaaa taaaatgaaa aaataaaaat ttttaaagct gtaattatct ccatctggta   6480

ggaatatata caatctgaaa taaaaaatat atttgtaatt gttaggacaa aatagattat   6540

acgttaagtc tgcaaattat aaattataaa attctcacag aacctgaaaa attattgata   6600

ctgttaaata tttaaaaagc tgtccttgga gagaaagaaa cctatcagat ttacatcaac   6660

aagtgtaata tgtcagccta ttaccatctg ctacagactg catgtttgtg ttccctcaaa   6720

attcatatga taggccgggc gcggtggc                                      6748


<210>  4627
<211>  1166
<212>  PRT
<213>  Homosapiens

<400>  4627

Met Pro Glu Gln Asp Lys Asp Pro Arg Val Gln Glu Asn Pro Asp Asp 
1               5                   10                  15      


Gln Arg Thr Val Pro Glu Val Thr Gly Asp Ala Arg Ser Ala Phe Trp 
            20                  25                  30          


Pro Leu Arg Asp Asn Gly Gly Pro Ser Pro Phe Val Pro Arg Pro Gly 
        35                  40                  45              


Pro Leu Gln Thr Asp Leu His Ala Gln Ser Ser Glu Ile Arg Tyr Asn 
    50                  55                  60                  


His Thr Ser Gln Thr Ser Trp Thr Ser Ser Ser Thr Lys Arg Asn Ala 
65                  70                  75                  80  


Ile Ser Ser Ser Tyr Ser Ser Thr Gly Gly Leu Pro Gly Leu Lys Gln 
                85                  90                  95      


Arg Arg Gly Pro Ala Ser Ser Arg Cys Gln Leu Thr Leu Ser Tyr Ser 
            100                 105                 110         


Lys Thr Val Ser Glu Asp Arg Pro Gln Ala Val Ser Ser Gly His Thr 
        115                 120                 125             


Arg Cys Glu Lys Gly Ala Asp Thr Ala Pro Gly Gln Thr Ile Ala Pro 
    130                 135                 140                 


Thr Gly Gly Ser Pro Arg Ser Gln Asp Ser Arg Pro Arg Arg Arg Lys 
145                 150                 155                 160 


Ile Pro Leu Leu Pro Arg Arg Arg Gly Glu Pro Leu Met Leu Pro Pro 
                165                 170                 175     


Pro Leu Glu Leu Gly Tyr Arg Val Thr Ala Glu Asp Leu His Leu Glu 
            180                 185                 190         


Lys Glu Thr Ala Phe Gln Arg Ile Asn Ser Ala Leu His Val Glu Asp 
        195                 200                 205             


Lys Ala Ile Pro Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser 
    210                 215                 220                 


Ser Leu Ala Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro 
225                 230                 235                 240 


Thr Met Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly 
                245                 250                 255     


Leu Val Ala Pro Leu Ala Ser Ala Ala Glu Val Pro Ala Thr Ala Pro 
            260                 265                 270         


Val Ser Gly Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser 
        275                 280                 285             


Asp Pro Leu Pro Ala Asn Ser Ser His Ser Arg Asp Ser Ala Gln Val 
    290                 295                 300                 


Thr Ser Met Ile Pro Ala Pro Phe Thr Ala Ala Ser Arg Asp Ala Gly 
305                 310                 315                 320 


Met Arg Arg Thr Arg Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro 
                325                 330                 335     


Pro Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp 
            340                 345                 350         


Gly Gly Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala 
        355                 360                 365             


Gln Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr 
    370                 375                 380                 


Arg Ser Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr 
385                 390                 395                 400 


Glu Gly Leu Gln Glu Val Lys Arg Arg Arg Gly Pro Ala Ser Ser His 
                405                 410                 415     


Cys Gln Leu Ala Leu Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro 
            420                 425                 430         


Gln Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala 
        435                 440                 445             


Pro Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala 
    450                 455                 460                 


Ser Arg Pro His Ile Asn Thr Ala Leu His Val Glu Asp Lys Ala Ile 
465                 470                 475                 480 


Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala 
                485                 490                 495     


Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp 
            500                 505                 510         


Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Ser Leu Gly Leu Leu Ala 
        515                 520                 525             


Pro Leu Ala Ser Ala Ala Glu Val Pro Ser Thr Ala Pro Val Ser Gly 
    530                 535                 540                 


Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu 
545                 550                 555                 560 


Pro Ala Thr Ser Tyr His Ser Arg Asp Thr Ala Gln Val Thr Ser Leu 
                565                 570                 575     


Ile Pro Ala Thr Phe Thr Ala Ala Ser Arg Asp Ala Gly Met Arg Arg 
            580                 585                 590         


Thr Arg Ser Ala Pro Ala Ala Ala Thr Ala Ala Pro Pro Pro Ser Thr 
        595                 600                 605             


Leu Asn Asn Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Gly Gly Pro 
    610                 615                 620                 


Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala Gln Arg Ser 
625                 630                 635                 640 


Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg Ser Cys 
                645                 650                 655     


Leu Lys Arg Asn Ala Ser Ser Ser Ser Ser Ser His Ser Ser Thr Glu 
            660                 665                 670         


Gly Leu Gln Glu Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser His Cys 
        675                 680                 685             


Gln Leu Ala His Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro Gln 
    690                 695                 700                 


Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala Pro 
705                 710                 715                 720 


Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala Ser 
                725                 730                 735     


Arg Pro His Ile Asn Ser Ala Leu Tyr Val Glu Asp Lys Ala Ile Ser 
            740                 745                 750         


Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala Thr 
        755                 760                 765             


Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp Ala 
    770                 775                 780                 


Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly Leu Val Ala Pro 
785                 790                 795                 800 


Leu Ala Ser Ala Ala Glu Val Pro Ser Thr Ala Pro Val Ser Gly Lys 
                805                 810                 815     


Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu Pro 
            820                 825                 830         


Ala Thr Ser Ser His Ser Arg Asp Ser Ala Gln Val Thr Ser Leu Ile 
        835                 840                 845             


Pro Ala Thr Phe Thr Ala Ala Ser Arg Asp Ala Gly Met Arg Arg Thr 
    850                 855                 860                 


Arg Pro Gly Thr Ser Ala Pro Ala Ala Ala Ala Ala Ala Leu Pro Pro 
865                 870                 875                 880 


Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Gly 
                885                 890                 895     


Gly Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala Gln 
            900                 905                 910         


Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg 
        915                 920                 925             


Ser Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr Glu 
    930                 935                 940                 


Gly Leu Gln Glu Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser His Cys 
945                 950                 955                 960 


Gln Leu Ala His Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro Gln 
                965                 970                 975     


Ala Val Ser Ser Gly His Arg Cys Glu Asn Lys Ala Gly Thr Ala Pro 
            980                 985                 990         


Gly Gln Thr Leu Ala Pro Arg Gly  Gly Tyr Pro Arg Ser  Gln Ala Ser 
        995                 1000                 1005             


Arg Pro  Arg Ile Asn Ser Ala  Leu His Val Glu Asp  Lys Ala Ile 
    1010                 1015                 1020             


Ser Asp  Cys Arg Pro Ser Arg  Pro Ser His Thr Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ala Thr  Gly Ala Ser Gly Gly  Pro Pro Val Ser Lys  Ala Pro Thr 
    1040                 1045                 1050             


Met Asp  Ala Gln Gln Asp Arg  Pro Lys Ser Gln Asp  Cys Leu Gly 
    1055                 1060                 1065             


Leu Leu  Ala Pro Leu Ala Ser  Ala Ala Glu Val Ser  Ser Thr Ala 
    1070                 1075                 1080             


Pro Val  Ser Gly Lys Lys His  Arg Pro Pro Gly Pro  Leu Phe Ser 
    1085                 1090                 1095             


Ser Ser  Asp Pro Leu Pro Ala  Thr Ser Ser His Ser  Gly Asp Ser 
    1100                 1105                 1110             


Ala Gln  Asp Thr Ser Leu Ile  Pro Ala Pro Phe Thr  Pro Ala Ser 
    1115                 1120                 1125             


Arg Asp  Ala Gly Ile Arg Arg  Met Phe Arg Val Arg  Asn Cys Leu 
    1130                 1135                 1140             


Arg Gly  Leu Gly Leu Phe Leu  Leu Val Phe Ser Phe  Phe Phe Leu 
    1145                 1150                 1155             


Leu Thr  Trp Ala Ser Phe Ser  Phe 
    1160                 1165     


<210>  4628
<211>  4519
<212>  DNA
<213>  Homosapiens

<400>  4628
atggcgctcc attccgactt agacaaggga gagggcactg cgaaatacac cctctcagga     60

gatggcgctg gcaccgtttt taccattgat gaaaccacag gggacattca tgcaataagg    120

agcctagata gagaagaaaa acctttctac actcttcgtg ctcaggctgt ggacatagaa    180

accagaaagc ccctggagcc tgaatcagaa ttcatcatca aagtgcagga tattaatgat    240

aatgagccaa agttttggga tggaccttat gttgctactg tcccagaaat gtctcctgtg    300

ggtgagtagg caaatcaaaa ttctgtgaga tacaatgaga cctcttcaac attgactttt    360

tgcaggttga tgtaaacatc ttatctatca tctaaaagaa ttatttttca attctagaaa    420

atacagttct tttcatttat ttttgtaact tttttgtttt tctttctgct tcattatgaa    480

gataactaca ggaatatata acattagttc ctgttttcca ccctgtgaat ttacctgaat    540

tcatagaatc cttgcgtgct ttaagcaaaa aatgtatttt gtattgaaat tgattcttat    600

ctcaattcca gacacctata cagtgctgga gacacctacc ctacaccacg aaatgccaga    660

cagtaattcc tagatcaaag taaatgatct aaagcatgca tcacatctga tctggaagtg    720

gtccagaaac aggtgtgttg catcttctgt agctgtaaat agagattctg gaagggtgat    780

actgtttcct tttcagggta aataacccat acttgttatg ccatcaagcc aagcagcaaa    840

tgaataatgt catgaaaata ttattagaac aaattaacaa attacaatta caattatcaa    900

attaacaatt agaatatagt agcaccatca ttctaaaaat ttaaatttga tataaatata    960

catttccata tcagcctaaa tttacaaagt cctataatat gtaggatata aggtcaataa   1020

gttaagaatt ccagccttaa ggacaatttt aaattataat ttttattcct cagtcaccac   1080

tgctaatcct tcaatttatt tcaaagtaac ttctggtttt tattacattt ggaagataaa   1140

gcaacttatc acatgtaggt tacaacttaa aattcgtgta tgagccattg cttatatttt   1200

ctaaatctga catgacccag ggggtttcta ctgctcctac caccacccag gacatgcgat   1260

gaagattgtg cacgctaccg tgagggcaga agcaggttag tagctgtagg agctgtcaca   1320

tggatttact ataatgcact tgaaattgtg tatgtgacct tatcaggcat ttaaggacca   1380

taatctctcc ttgacctaag aaatcagctt gaagtaattc acttagattt caaattttaa   1440

tgtggatacc caaggctgca aatctgttat tcagtacctg ctacactttt ggggttgcct   1500

cttttatgca ctgttagaat tgctagaaat ttagaagtcc aattggaaag aagcatatct   1560

tgttagaaag tattcccaga aaatgaggaa ggctacattt taactgtgtc ttgattttac   1620

agggagaaaa ataaagttaa tattttgagg aaaaaataag gcttttaaga tgacatgcta   1680

tatagtagac aaatagttta actcggtgcc tacttcatgt acactggatg tgttaacatg   1740

aatttatgac cctcagtgac tttttattac caaaacagct tccttaaagc aaacacacac   1800

acatgcctct acagtattgg aaaattccgt ctccttagat aaaacaatta ggatttttct   1860

tgggccaact agaataatta gggctgcaga gttggagcct ttatataagg agtttgcagc   1920

tcatatccga agagagaaat gtatttcgaa agtcaaaagt gtagttaagt gagaaagcag   1980

agtagtttca gcttttgcat ttggagtggg tataatttac tgtgttgtca taagatactg   2040

gaaagatctt tggaagaata ggttcttaaa gtgttttctc atgtgccctt actgacattt   2100

cccattgggc cttcaagaca actccagtaa atacttaaat tgattttcag tgcactgctt   2160

tctttcattt ttatttattt attttgagac tgggtcttgg tctgttgccc tggctggagt   2220

gcaatggccc aatcttagct cactgaagcc ttaaattcct gggctgaaga gatccctcca   2280

cctgagcctc cttaatagcc agtcatgtgc caccctgcct agctattttt tttttttttt   2340

tttttttttt tactttttgt agagaaggga tctagctatg ttgcccaggc tgttctcaag   2400

tagtcctggc ctcaaatgat ccctccacct tggcttccca gagcactggg attacagtca   2460

tgagccaccc tcctggctcc tttttttttt tatttttaat aacagaaggg tatttctttt   2520

gaatgtgaaa ttttaccaca tggtatgaat tagtccaagt gtttttatac taaatttaca   2580

taatatacac ttttcaagta agtacaaaga ggtataaaca ctgcttatga attgaatgtt   2640

aaaaaataaa tctctatgca ttacttttgt ctttccccat aatctcacgt atacacataa   2700

aacaaaaaac aaggagaccc agttatagtt gtggtatctg ctgtttctgc cttgaaattt   2760

ccagcttaca gctaagcaac aactactgtg catccagaac ttacatctat gttcctagag   2820

tacttgaacc ccattctcaa gtgcaccctt cttaccaggt ggaaatagtt cactgctgta   2880

ataatctaag aaaacattat gtttctctct actttttttt ctctcatata atctaggcaa   2940

ttctccctct gtatcatttt cctgagaaaa ctaaaataat ttttaatcaa gaccagatgg   3000

aactttgtat ggtatattga cagtatacca attgttgtga cgaatcttac tgcctgttgt   3060

agatatcagt gtttgaagta ttccctatga aataactttt ctgtcccaat aattgagagt   3120

gctgtttcat ttccaaaaaa agggaagaat taatcaatta aacatacata tagtgaaata   3180

acctgttttg taacataaaa cataagatga agaaatatcg gaacattgat atgaagttta   3240

acagtaatgg attatatatc cagaaatatg aacaaataaa cctgcaatga aaatttacta   3300

atgttactaa ttttcacttg tgtaacatga acattacaaa gaacatagtg tacaaaggga   3360

gaatgttggt gggtaggatg agtcaagatt tcagaggaaa atcaatattt aagacttaca   3420

gcactgtgga atatatttaa ttttcctaaa gttgaagaaa atttcagtga atctatgaat   3480

tgtttaagag aaaggtcact ccgttactga cttctgctac atctaatatt ccagggaagt   3540

aatatttaga gataaaaagc ttttactctg acctccggaa attacttaat gatccagata   3600

ctcccaaagt caaagcaaat ccttggagac aagtttggac tttatgaatg tggacttaat   3660

tctttaagat cactagagca acaataaatt acaggaatgt accctcttta tatctgatga   3720

ttatgcataa gtggggtgtg cagttttaag ttacttttcc tacagtgctg acaggtttag   3780

agtgttaaat ccatactcaa cttgtattat cttcctctgc ttgagctatg ccaccttgag   3840

tcagctgatt tgactattta taattagata cctaacctat gatatgatat agtagatgtc   3900

aatagtgact catgatttat gtagtaagtc ttaccatttt ctaagcagta gtcaggtgcc   3960

atgtgatcta actaaagatt tgtatttctt attttactta acaattacag taaccccaat   4020

gcagtattat tcactgttgg atttttttta atgtgaaaac ttaataaccg ctgtggataa   4080

gaaagtaaga atgattctta ggtgctttag gaccaaatta atcagaattt aatataccac   4140

tttgtctagg tgtcatggcg gctaaaatat ctttgagaaa gttaaactta gctttcaatc   4200

tcagatgatc tacttaagaa tttggaaagt ttatattata ttatttgaga atggggattc   4260

ttgcttaaac gaaacctgaa ggacgggcat ctttcattca atatcttaaa aagaaagttt   4320

agctgacatt taaataagaa aagatacacc taaaataaag tagaacactg gtttaataaa   4380

aatagtgaac aggtactccc ttgcctttct atttttctct caactctatt ttattttacc   4440

tgaagtttgg ggagaaatgc taagatgaaa tttttggtgg agtctttcag aggttattta   4500

accagagact attttcttt                                                4519


<210>  4629
<211>  102
<212>  PRT
<213>  Homosapiens

<400>  4629

Met Ala Leu His Ser Asp Leu Asp Lys Gly Glu Gly Thr Ala Lys Tyr 
1               5                   10                  15      


Thr Leu Ser Gly Asp Gly Ala Gly Thr Val Phe Thr Ile Asp Glu Thr 
            20                  25                  30          


Thr Gly Asp Ile His Ala Ile Arg Ser Leu Asp Arg Glu Glu Lys Pro 
        35                  40                  45              


Phe Tyr Thr Leu Arg Ala Gln Ala Val Asp Ile Glu Thr Arg Lys Pro 
    50                  55                  60                  


Leu Glu Pro Glu Ser Glu Phe Ile Ile Lys Val Gln Asp Ile Asn Asp 
65                  70                  75                  80  


Asn Glu Pro Lys Phe Trp Asp Gly Pro Tyr Val Ala Thr Val Pro Glu 
                85                  90                  95      


Met Ser Pro Val Gly Glu 
            100         


<210>  4630
<211>  1889
<212>  DNA
<213>  Homosapiens

<400>  4630
ccggcggctg ttgtcgggcc tccagcgggc ggggccgttg gcggagcaga gcggaggcgc     60

agccgggcgg agggcccacg agggctcagc cttcccggtc agcggtggtg acggtatccc    120

agagtgccag agaaccgttg cttttccgag ttgctcttct tccaggctcc gttggtggtc    180

ggcatggccc gtggaaatca acgagaactt gcccgccaga aaaacatgaa gaaaacccag    240

gaaattagca agggaaagag gaaagaggat agcttgactg cctctcagag aaagcagagt    300

tctggaggcc agaaatctga gagcaagatg tcagctgggc cacacctccc tctgaaggct    360

ccaagggaga atccttgctt tcctcttcca gctgctggtg gctccaggta ttacttggct    420

tatggcagca taactcctat ctctgccttt gtctttgtgg tcttcttttc tgtcttcttc    480

ccttcttttt atgaggactt ttgctgttgg atttaggttc cattctaacc taggatgatc    540

tcatttggaa atccttaatt tcatctacaa aaactgtttt cccaaatagg tcacattcac    600

gcatatcaga tggacagatg tatcattttg gggtccacca ttcaacccac tacaaggagt    660

tttttaaaca aaaataggaa acttagatgt aacttagcac tttttttttt tttttttgag    720

atggagtctc actctgtcac cagactggag tgcagtggcg ccatctcagc tccatgcaac    780

ctctgcctcc tgggttcaag cagttctctt gcctcagcct cctgggtagc tgggattaca    840

ggcacgcgct gccacaccca ggtaatttat ttattttttt tttgagacag agtctcgcac    900

tgttgcccag gctggactgc agtggcgtga tctctgctca ctgcaacctc cgcctcccgg    960

gttcaagcga ttctccagcc tcagcttcct gagtagatgg gattacaggc gcctgccacc   1020

acgcccagct aattttttgt attcttagta gagatggggt ttcaccatgt tggccaggct   1080

ggtctccatc tcctgacctc gtgattcacc cgcctcggcc tcccaaagtg ctgggattac   1140

aggcgtgagt cacagccccc ggccataatt tagcacttta aaaaataata gccatgttgg   1200

gccaggcgtg gtggctcatg cctgtaatct gagcactttg ggagaccaag gcgggtagat   1260

cccttgtgcc caggagttca agaccagcct gggcaacatg gcgaaacccc atttctacta   1320

aaaatacaaa aattagctgg ggcgagggga taggccgagt tccgggtgta agggggccat   1380

tagggagagc agagcgaggc agctgatctt ccggattggg ggccttgccc ggaagctgga   1440

cctcacggag atgaaacgga agatgcacga ggatatgatc tccatacaga actttctcat   1500

ctacgtggcc ctgctgcgag tcactccatt tatcttaaag aaattggaca gcatatgaag   1560

attggacatc acatgtgaat gcatgatatg aagagcctgg ttacagtttc tactgttctc   1620

tgcaagtaaa taggcccaga aaggtataag agactctttg aatggacata aaaattctgc   1680

ttgttaagaa caagttgagc tctggtaact gatcttaata gctaaaatat aaaaatattt   1740

gggaagtctg aaatgaggtc tcctggccct ggtgtgccct taatgcctgt gacagttggc   1800

ctctgtgaat attggtataa ttgtaaataa tgtcaaactc cattttctag caagtattaa   1860

taattaaggg aagtatgtct gaaatggca                                     1889


<210>  4631
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  4631

Met Ala Arg Gly Asn Gln Arg Glu Leu Ala Arg Gln Lys Asn Met Lys 
1               5                   10                  15      


Lys Thr Gln Glu Ile Ser Lys Gly Lys Arg Lys Glu Asp Ser Leu Thr 
            20                  25                  30          


Ala Ser Gln Arg Lys Gln Ser Ser Gly Gly Gln Lys Ser Glu Ser Lys 
        35                  40                  45              


Met Ser Ala Gly Pro His Leu Pro Leu Lys Ala Pro Arg Glu Asn Pro 
    50                  55                  60                  


Cys Phe Pro Leu Pro Ala Ala Gly Gly Ser Arg Tyr Tyr Leu Ala Tyr 
65                  70                  75                  80  


Gly Ser Ile Thr Pro Ile Ser Ala Phe Val Phe Val Val Phe Phe Ser 
                85                  90                  95      


Val Phe Phe Pro Ser Phe Tyr Glu Asp Phe Cys Cys Trp Ile 
            100                 105                 110 


<210>  4632
<211>  1917
<212>  DNA
<213>  Homosapiens

<400>  4632
atgtcaaggg aagccattca tgtgggggta ctgtgcgctg ctgaccattg ggtgctgctg     60

aagttaggca ccgcccaaga agtgtgcagc cagaacgagg tgctgcagag gcagagtgta    120

tgtgctacag gagctggtat tgcagatggc acaggtgttg caggtgtctg cctagaggag    180

cacaatggaa ccaggaaaag cagcccttgc cccttcagtg tgtcagcagc accctcgatt    240

gacaaagttt cactctgtgc ttactgtcat gggagaggat tttacctcct ccattccacc    300

aaaacagctc ttatgagggt caccaatgag ctccacattg ctaaattggt taaaaatgtg    360

tctgcaggca cacaggacgt gccttcaccc ccatctgact atgtggaaag agttgacagt    420

cccatggcat actcttccaa tggcaaagtg aatgacaagc ggttttatcc agagtcttcc    480

tataaatcca cgccggttcc tgaagtggtt caggagcttc cattaacttc gcctgtggat    540

gacttcaggc agcctcgtta cagcagcggt ggtaactttg agacaccttc aaaaagagca    600

cctgcaaagg gaagagcagg aaggtcaaag agaacagagc aagatcacta tgagacagac    660

tacacaactg gtggcgagtc ctgtgatgag ctggaggagg actggatcag ggaatatcca    720

cctatcactt cagatcaaca aagacaactg tacaagagga attttgacac tggcctacag    780

gaatacaaga gcttacaatc agaacttgat gagatcaata aagaactctc ccgtttggat    840

aaagaattgg atgactatag agaagaaagt gaagagtaca tggctgctgc tgatgaatac    900

aatagactga agcaagtgaa gggatctgca gattacaaaa gtaagaagaa tcattgcaag    960

cagttaaaca gcaaattgtc acacatcaag aagatggttg gagactatga tagacagaaa   1020

acatagaagg ctgatgccaa gttgtttgag aaattaagta tctgacatct ctgcaatctt   1080

ctcagaaggc aaatgacttt ggaccataac cccggaagcc aaacctctgt gagcatcaca   1140

gttttggttg ctttaatatc atcagtattg aagcatttta taaatcgctt ttgataatca   1200

actgggctga acactccaat taaggatttt atgctttaaa cattggttct tgtattaaga   1260

atgaaatact gtttgaggtt tttaagcctt aaaggaaggt tctggtgtga actaaacttt   1320

cacaccccag acgatgtctt catacctaca tgtatttgtt tgcataggtg atctcattta   1380

atcctctcaa ccacctttca gataactgtt atttataatc acttttttcc acataaggaa   1440

actgggttcc tgcaatgaag tctctgaagt gaaactgctt gtttcctagc acacactttt   1500

ggttaagtct gttttatgac ttcattaata ataaattccc tggcctttca tattttagct   1560

actatatatg tgatgatcta ccagcctccc tatttttttt ctgttatata aatggttaaa   1620

agaggttttt cttaaataat aaagatcatg taaaagtaac aaatgtgtga aatttaaaga   1680

ttgtaaatat atatttactt ttttaagatc aaagtttaaa cccggtggtt agaattttgt   1740

gtgtttttaa atacttttta tctttttgca tgcctttttt taaaaaccaa ctagaacttt   1800

tcattatatc agaatatctg attacattta taattcaatt gtgacttgaa ctgtatctta   1860

caggaatgtt caatttctat acatatttta taaggtatta aacctggtgt tttcttt      1917


<210>  4633
<211>  341
<212>  PRT
<213>  Homosapiens

<400>  4633

Met Ser Arg Glu Ala Ile His Val Gly Val Leu Cys Ala Ala Asp His 
1               5                   10                  15      


Trp Val Leu Leu Lys Leu Gly Thr Ala Gln Glu Val Cys Ser Gln Asn 
            20                  25                  30          


Glu Val Leu Gln Arg Gln Ser Val Cys Ala Thr Gly Ala Gly Ile Ala 
        35                  40                  45              


Asp Gly Thr Gly Val Ala Gly Val Cys Leu Glu Glu His Asn Gly Thr 
    50                  55                  60                  


Arg Lys Ser Ser Pro Cys Pro Phe Ser Val Ser Ala Ala Pro Ser Ile 
65                  70                  75                  80  


Asp Lys Val Ser Leu Cys Ala Tyr Cys His Gly Arg Gly Phe Tyr Leu 
                85                  90                  95      


Leu His Ser Thr Lys Thr Ala Leu Met Arg Val Thr Asn Glu Leu His 
            100                 105                 110         


Ile Ala Lys Leu Val Lys Asn Val Ser Ala Gly Thr Gln Asp Val Pro 
        115                 120                 125             


Ser Pro Pro Ser Asp Tyr Val Glu Arg Val Asp Ser Pro Met Ala Tyr 
    130                 135                 140                 


Ser Ser Asn Gly Lys Val Asn Asp Lys Arg Phe Tyr Pro Glu Ser Ser 
145                 150                 155                 160 


Tyr Lys Ser Thr Pro Val Pro Glu Val Val Gln Glu Leu Pro Leu Thr 
                165                 170                 175     


Ser Pro Val Asp Asp Phe Arg Gln Pro Arg Tyr Ser Ser Gly Gly Asn 
            180                 185                 190         


Phe Glu Thr Pro Ser Lys Arg Ala Pro Ala Lys Gly Arg Ala Gly Arg 
        195                 200                 205             


Ser Lys Arg Thr Glu Gln Asp His Tyr Glu Thr Asp Tyr Thr Thr Gly 
    210                 215                 220                 


Gly Glu Ser Cys Asp Glu Leu Glu Glu Asp Trp Ile Arg Glu Tyr Pro 
225                 230                 235                 240 


Pro Ile Thr Ser Asp Gln Gln Arg Gln Leu Tyr Lys Arg Asn Phe Asp 
                245                 250                 255     


Thr Gly Leu Gln Glu Tyr Lys Ser Leu Gln Ser Glu Leu Asp Glu Ile 
            260                 265                 270         


Asn Lys Glu Leu Ser Arg Leu Asp Lys Glu Leu Asp Asp Tyr Arg Glu 
        275                 280                 285             


Glu Ser Glu Glu Tyr Met Ala Ala Ala Asp Glu Tyr Asn Arg Leu Lys 
    290                 295                 300                 


Gln Val Lys Gly Ser Ala Asp Tyr Lys Ser Lys Lys Asn His Cys Lys 
305                 310                 315                 320 


Gln Leu Asn Ser Lys Leu Ser His Ile Lys Lys Met Val Gly Asp Tyr 
                325                 330                 335     


Asp Arg Gln Lys Thr 
            340     


<210>  4634
<211>  1919
<212>  DNA
<213>  Homosapiens

<400>  4634
atgtcaaggg aagccattca tgtgggggta ctgtgcgctg ctgaccattg ggtgctgctg     60

aagttaggca ccgcccaaga agtgtgcagc cagaacgagg tgctgcagag gcagagtgta    120

tgtgctacag gagctggtat tgcagatggc acaggtgttg caggtgtctg cctagaggag    180

cacaatggaa ccaggaaaag cagcccttgc cccttcagtg tgtcagcagc accctcgatt    240

gacaaagttt cactctgtgc ttactgtcat gggagaggat tttacctcct ccattccacc    300

aaaacagctc ttatgagggt caccaatgag ctccacattg ctaaattggt taaaaatgtg    360

tctgcaggca cacaggacgt gccttcaccc ccatctgact atgtggaaag agttgacagt    420

cccatggcat actcttccaa tggcaaagtg aatgacaagc ggttttatcc agagtcttcc    480

tataaatcca cgccggttcc tgaagtggtt caggagcttc cattaacttc gcctgtggat    540

gacttcaggc agcctcgtta cagcagcggt ggtaactttg agacaccttc aaaaagagca    600

cctgcaaagg gaagagcagg aaggtcaaag agaacagagc aagatcacta tgagacagac    660

tacacaactg gcggcgagtc ctgtgatgag ctggaggagg actggatcag ggaatatcca    720

cctatcactt cagatcaaca aagacaactg tacaagagga attttgacac tggcctacag    780

gaatacaaga gcttacaatc agaacttgat gagatcaata aagaactctc ccgtttggat    840

aaagaattgg atgactatag agaagaaagt gaagagtaca tggctgctgc tgatgaatac    900

aatagactga agcaagtgaa gggatctgca gattacaaaa gtaagaagaa tcattgcaag    960

cagttaaaga gcaaattgtc acacatcaag aagatggttg gagactatga tagacagaaa   1020

acatagaagg ctgatgccaa gttgtttgag aaattaagta tctgacatct ctgcaatctt   1080

ctcagaaggc aaatgacttt ggaccataac cccggaagcc aaacctctgt gagcatcaca   1140

aagttttggt tgctttaaca tcatcagtat tgaagcattt tataaatcgc ttttgataat   1200

caactgggct gaacactcca attaaggatt ttatgcttta aacattggtt cttgtattaa   1260

gaatgaaata ctgtttgagg tttttaagcc ttaaaggaag gttctggtgt gaactaaact   1320

ttcacacccc agacgatgtc ttcataccta catgtatttg tttgcatagg tgatctcatt   1380

taatcctctc aaccaccttt cagataactg ttatttataa tcactttttt ccacataagg   1440

aaactgggtt cctgcaatga agtctctgaa gtgaaactgc ttgtttccta gcacacactt   1500

ttggttaagt ctgttttatg acttcattaa taataaattc cctggccttt catattttag   1560

ctactatata tgtgatgatc taccagcctc cctatttttt ttctgttata taaatggtta   1620

aaagaggttt ttcttaaata ataaagatca tgtaaaagta acaaatgtgt gaaatttaaa   1680

gattgtaaat atatatttac ttttttaaga tcaaagttta aaccccgtgg ttagaatttt   1740

gtgtgttttt aaatactttt tatctttttg catgcctttt ttaaaaaacc aactagaact   1800

tttcattata tcagaatatc tgattacatt tataattcaa ttgtgacttg aactgtatct   1860

tacaggaatg ttcaatttct atacatattt tataaggtat taaacctggt gttttcttt    1919


<210>  4635
<211>  341
<212>  PRT
<213>  Homosapiens

<400>  4635

Met Ser Arg Glu Ala Ile His Val Gly Val Leu Cys Ala Ala Asp His 
1               5                   10                  15      


Trp Val Leu Leu Lys Leu Gly Thr Ala Gln Glu Val Cys Ser Gln Asn 
            20                  25                  30          


Glu Val Leu Gln Arg Gln Ser Val Cys Ala Thr Gly Ala Gly Ile Ala 
        35                  40                  45              


Asp Gly Thr Gly Val Ala Gly Val Cys Leu Glu Glu His Asn Gly Thr 
    50                  55                  60                  


Arg Lys Ser Ser Pro Cys Pro Phe Ser Val Ser Ala Ala Pro Ser Ile 
65                  70                  75                  80  


Asp Lys Val Ser Leu Cys Ala Tyr Cys His Gly Arg Gly Phe Tyr Leu 
                85                  90                  95      


Leu His Ser Thr Lys Thr Ala Leu Met Arg Val Thr Asn Glu Leu His 
            100                 105                 110         


Ile Ala Lys Leu Val Lys Asn Val Ser Ala Gly Thr Gln Asp Val Pro 
        115                 120                 125             


Ser Pro Pro Ser Asp Tyr Val Glu Arg Val Asp Ser Pro Met Ala Tyr 
    130                 135                 140                 


Ser Ser Asn Gly Lys Val Asn Asp Lys Arg Phe Tyr Pro Glu Ser Ser 
145                 150                 155                 160 


Tyr Lys Ser Thr Pro Val Pro Glu Val Val Gln Glu Leu Pro Leu Thr 
                165                 170                 175     


Ser Pro Val Asp Asp Phe Arg Gln Pro Arg Tyr Ser Ser Gly Gly Asn 
            180                 185                 190         


Phe Glu Thr Pro Ser Lys Arg Ala Pro Ala Lys Gly Arg Ala Gly Arg 
        195                 200                 205             


Ser Lys Arg Thr Glu Gln Asp His Tyr Glu Thr Asp Tyr Thr Thr Gly 
    210                 215                 220                 


Gly Glu Ser Cys Asp Glu Leu Glu Glu Asp Trp Ile Arg Glu Tyr Pro 
225                 230                 235                 240 


Pro Ile Thr Ser Asp Gln Gln Arg Gln Leu Tyr Lys Arg Asn Phe Asp 
                245                 250                 255     


Thr Gly Leu Gln Glu Tyr Lys Ser Leu Gln Ser Glu Leu Asp Glu Ile 
            260                 265                 270         


Asn Lys Glu Leu Ser Arg Leu Asp Lys Glu Leu Asp Asp Tyr Arg Glu 
        275                 280                 285             


Glu Ser Glu Glu Tyr Met Ala Ala Ala Asp Glu Tyr Asn Arg Leu Lys 
    290                 295                 300                 


Gln Val Lys Gly Ser Ala Asp Tyr Lys Ser Lys Lys Asn His Cys Lys 
305                 310                 315                 320 


Gln Leu Lys Ser Lys Leu Ser His Ile Lys Lys Met Val Gly Asp Tyr 
                325                 330                 335     


Asp Arg Gln Lys Thr 
            340     


<210>  4636
<211>  2874
<212>  DNA
<213>  Homosapiens

<400>  4636
atggtaatat tgtgggaact gagtgaaaat tcagaatgtg aatttcttcg gagtaagaaa     60

tcctcagagg aaattaccca gtatattcaa agctacaagg gatttgttga cataacggga    120

gaacattttg tgaattcctg ggtccagaga gaattaccta tggcatcagc ttattgcaat    180

gacagcatct ttgcttacga agaactacgg ctggactctt ttaaggactg gccccgggaa    240

tcagctgtgg gagttgcagc actggccaaa gcaggtcttt tctacacagg tataaaggac    300

atcgtccagt gcttttcctg tggagggtgt ttagagaaat ggcaggaagg tgatgaccca    360

ttagacgatc acaccagatg ttttcccaat tgtccatttc tccaaaatat gaagtcctct    420

gcggaagtga ctccagacct tcagagccgt ggtgaacttt gtgaattact ggaaaccaca    480

agtgaaagca atcttgaaga ttcaatagca gttggtccta tagtgccaga aatggcacag    540

ggtgaagccc agtggtttca agaggcaaag aatctgaatg agcagctgag agcagcttat    600

accagcgcca gtttccgcca catgtctttg cttgatatct cttccgatct ggccacggac    660

cacttgctgg gctgtgatct gtctattgct tcaaaacaca tcagcaaacc tgtgcaagaa    720

cctctggtgc tgcctgaggt ctttggcaac ttgaactctg tcatgtgtgt ggagggtgaa    780

gctggaagtg gaaagacggt cctcctgaag aaaatagctt ttctgtgggc atctggatgc    840

tgtcccctgt taaacaggtt ccagctggtt ttctacctct cccttagttc caccagacca    900

gacgaggggc tggccagtat catctgtgac cagctcctag agaaagaagg atctgttact    960

gaaatgtgcg tgaggaacat tatccagcag ttaaagaatc aggtcttatt ccttttagat   1020

gactacaaag aaatatgttc aatccctcaa gtcataggaa aactgattca aaaaaaccac   1080

ttatcccgga cctgcctatt gattgctgtc cgtacaaaca gggccaggga catccgccga   1140

tacctagaga ccattctaga gatcaaagca tttccctttt ataatactgt ctgtatatta   1200

cggaagctct tttcacataa tatgactcgt ctgcgaaagt ttatggttta ctttggaaag   1260

aaccaaagtt tgcagaagat acagaaaact cctctctttg tggcggcgat ctgtgctcat   1320

tggtttcagt atccttttga cccatccttt gatgatgtgg ctgttttcaa gtcctatatg   1380

gaacgccttt ccttaaggaa caaagcgaca gctgaaattc tcaaagcaac tgtgtcctcc   1440

tgtggtgagc tggccttgaa agggtttttt tcatgttgct ttgagtttaa tgatgatgat   1500

ctcgcagaag caggggttga tgaagatgaa gatctaacca tgtgcttgat gagcaaattt   1560

acagcccaga gactaagacc attctaccgg tttttaagtc ctgccttcca agaatttctt   1620

gcggggatga ggctgattga actcctggat tcagataggc aggaacatca agatttggga   1680

ctgtatcatt tgaaacaaat caactcaccc atgatgactg taagcgccta caacaatttt   1740

ttgaactatg tctccagcct cccttcaaca aaagcagggc ccaaaattgt gtctcatttg   1800

ctccatttag tggataacaa agagtcattg gagaatatat ctgaaaatga tgactactta   1860

aagcaccagc cagaaatttc actgcagatg cagttactta ggggattgtg gcaaatttgt   1920

ccacaagctt acttttcaat ggtttcagaa catttactgg ttcttgccct gaaaactgct   1980

tatcaaagca acactgttgc tgcgtgttct ccatttgttt tgcaattcct tcaagggaga   2040

acactgactt tgggtgcgct taacttacag tactttttcg accacccaga aagcttgtca   2100

ttgttgagga gcatccactt ctcaatacga ggaaataaga catcacccag agcacatttt   2160

tcagttctgg aaacatgttt tgacaaatca caggtgccaa ctatagatca ggactatgct   2220

tctgcctttg aacctatgaa tgaatgggag cgaaatttag ctgaaaaaga ggataatgta   2280

aagagctata tggatatgca gcgcagggca tcaccagacc ttagtactgg ctattggaaa   2340

ctttctccaa agcagtacaa gattccctgt ctagaagtcg atgtgaatga tattgatgtt   2400

gtaggccagg atatgcttga gattctaatg acagttttct cagcttcaca gcgcatcgaa   2460

ctccatttaa accacagcag aggctttata gaaagcatcc gcccagctct tgagctgtct   2520

aaggcctctg tcaccaagtg ctccataagc aagttggaac tcagcgcagc cgaacaggaa   2580

ctgcttctca ccctgccttc cctggaatct cttgaagtct cagggacaat ccagtcacaa   2640

gaccaaatct ttcctaatct ggataagttc ctgtgcctga aagaactgtc tgtggatctg   2700

gagggcaata taaatgtttt ttcagtcatt cctgaagaat ttccaaactt ccaccatatg   2760

gagaaattat tgatccaaat ttcagctgag tatgatcctt ccaaactagg ctggtcttac   2820

attgcaactt acagatctgg cagctcagca ggaaggaaat ctgctaatcc gtag         2874


<210>  4637
<211>  957
<212>  PRT
<213>  Homosapiens

<400>  4637

Met Val Ile Leu Trp Glu Leu Ser Glu Asn Ser Glu Cys Glu Phe Leu 
1               5                   10                  15      


Arg Ser Lys Lys Ser Ser Glu Glu Ile Thr Gln Tyr Ile Gln Ser Tyr 
            20                  25                  30          


Lys Gly Phe Val Asp Ile Thr Gly Glu His Phe Val Asn Ser Trp Val 
        35                  40                  45              


Gln Arg Glu Leu Pro Met Ala Ser Ala Tyr Cys Asn Asp Ser Ile Phe 
    50                  55                  60                  


Ala Tyr Glu Glu Leu Arg Leu Asp Ser Phe Lys Asp Trp Pro Arg Glu 
65                  70                  75                  80  


Ser Ala Val Gly Val Ala Ala Leu Ala Lys Ala Gly Leu Phe Tyr Thr 
                85                  90                  95      


Gly Ile Lys Asp Ile Val Gln Cys Phe Ser Cys Gly Gly Cys Leu Glu 
            100                 105                 110         


Lys Trp Gln Glu Gly Asp Asp Pro Leu Asp Asp His Thr Arg Cys Phe 
        115                 120                 125             


Pro Asn Cys Pro Phe Leu Gln Asn Met Lys Ser Ser Ala Glu Val Thr 
    130                 135                 140                 


Pro Asp Leu Gln Ser Arg Gly Glu Leu Cys Glu Leu Leu Glu Thr Thr 
145                 150                 155                 160 


Ser Glu Ser Asn Leu Glu Asp Ser Ile Ala Val Gly Pro Ile Val Pro 
                165                 170                 175     


Glu Met Ala Gln Gly Glu Ala Gln Trp Phe Gln Glu Ala Lys Asn Leu 
            180                 185                 190         


Asn Glu Gln Leu Arg Ala Ala Tyr Thr Ser Ala Ser Phe Arg His Met 
        195                 200                 205             


Ser Leu Leu Asp Ile Ser Ser Asp Leu Ala Thr Asp His Leu Leu Gly 
    210                 215                 220                 


Cys Asp Leu Ser Ile Ala Ser Lys His Ile Ser Lys Pro Val Gln Glu 
225                 230                 235                 240 


Pro Leu Val Leu Pro Glu Val Phe Gly Asn Leu Asn Ser Val Met Cys 
                245                 250                 255     


Val Glu Gly Glu Ala Gly Ser Gly Lys Thr Val Leu Leu Lys Lys Ile 
            260                 265                 270         


Ala Phe Leu Trp Ala Ser Gly Cys Cys Pro Leu Leu Asn Arg Phe Gln 
        275                 280                 285             


Leu Val Phe Tyr Leu Ser Leu Ser Ser Thr Arg Pro Asp Glu Gly Leu 
    290                 295                 300                 


Ala Ser Ile Ile Cys Asp Gln Leu Leu Glu Lys Glu Gly Ser Val Thr 
305                 310                 315                 320 


Glu Met Cys Val Arg Asn Ile Ile Gln Gln Leu Lys Asn Gln Val Leu 
                325                 330                 335     


Phe Leu Leu Asp Asp Tyr Lys Glu Ile Cys Ser Ile Pro Gln Val Ile 
            340                 345                 350         


Gly Lys Leu Ile Gln Lys Asn His Leu Ser Arg Thr Cys Leu Leu Ile 
        355                 360                 365             


Ala Val Arg Thr Asn Arg Ala Arg Asp Ile Arg Arg Tyr Leu Glu Thr 
    370                 375                 380                 


Ile Leu Glu Ile Lys Ala Phe Pro Phe Tyr Asn Thr Val Cys Ile Leu 
385                 390                 395                 400 


Arg Lys Leu Phe Ser His Asn Met Thr Arg Leu Arg Lys Phe Met Val 
                405                 410                 415     


Tyr Phe Gly Lys Asn Gln Ser Leu Gln Lys Ile Gln Lys Thr Pro Leu 
            420                 425                 430         


Phe Val Ala Ala Ile Cys Ala His Trp Phe Gln Tyr Pro Phe Asp Pro 
        435                 440                 445             


Ser Phe Asp Asp Val Ala Val Phe Lys Ser Tyr Met Glu Arg Leu Ser 
    450                 455                 460                 


Leu Arg Asn Lys Ala Thr Ala Glu Ile Leu Lys Ala Thr Val Ser Ser 
465                 470                 475                 480 


Cys Gly Glu Leu Ala Leu Lys Gly Phe Phe Ser Cys Cys Phe Glu Phe 
                485                 490                 495     


Asn Asp Asp Asp Leu Ala Glu Ala Gly Val Asp Glu Asp Glu Asp Leu 
            500                 505                 510         


Thr Met Cys Leu Met Ser Lys Phe Thr Ala Gln Arg Leu Arg Pro Phe 
        515                 520                 525             


Tyr Arg Phe Leu Ser Pro Ala Phe Gln Glu Phe Leu Ala Gly Met Arg 
    530                 535                 540                 


Leu Ile Glu Leu Leu Asp Ser Asp Arg Gln Glu His Gln Asp Leu Gly 
545                 550                 555                 560 


Leu Tyr His Leu Lys Gln Ile Asn Ser Pro Met Met Thr Val Ser Ala 
                565                 570                 575     


Tyr Asn Asn Phe Leu Asn Tyr Val Ser Ser Leu Pro Ser Thr Lys Ala 
            580                 585                 590         


Gly Pro Lys Ile Val Ser His Leu Leu His Leu Val Asp Asn Lys Glu 
        595                 600                 605             


Ser Leu Glu Asn Ile Ser Glu Asn Asp Asp Tyr Leu Lys His Gln Pro 
    610                 615                 620                 


Glu Ile Ser Leu Gln Met Gln Leu Leu Arg Gly Leu Trp Gln Ile Cys 
625                 630                 635                 640 


Pro Gln Ala Tyr Phe Ser Met Val Ser Glu His Leu Leu Val Leu Ala 
                645                 650                 655     


Leu Lys Thr Ala Tyr Gln Ser Asn Thr Val Ala Ala Cys Ser Pro Phe 
            660                 665                 670         


Val Leu Gln Phe Leu Gln Gly Arg Thr Leu Thr Leu Gly Ala Leu Asn 
        675                 680                 685             


Leu Gln Tyr Phe Phe Asp His Pro Glu Ser Leu Ser Leu Leu Arg Ser 
    690                 695                 700                 


Ile His Phe Ser Ile Arg Gly Asn Lys Thr Ser Pro Arg Ala His Phe 
705                 710                 715                 720 


Ser Val Leu Glu Thr Cys Phe Asp Lys Ser Gln Val Pro Thr Ile Asp 
                725                 730                 735     


Gln Asp Tyr Ala Ser Ala Phe Glu Pro Met Asn Glu Trp Glu Arg Asn 
            740                 745                 750         


Leu Ala Glu Lys Glu Asp Asn Val Lys Ser Tyr Met Asp Met Gln Arg 
        755                 760                 765             


Arg Ala Ser Pro Asp Leu Ser Thr Gly Tyr Trp Lys Leu Ser Pro Lys 
    770                 775                 780                 


Gln Tyr Lys Ile Pro Cys Leu Glu Val Asp Val Asn Asp Ile Asp Val 
785                 790                 795                 800 


Val Gly Gln Asp Met Leu Glu Ile Leu Met Thr Val Phe Ser Ala Ser 
                805                 810                 815     


Gln Arg Ile Glu Leu His Leu Asn His Ser Arg Gly Phe Ile Glu Ser 
            820                 825                 830         


Ile Arg Pro Ala Leu Glu Leu Ser Lys Ala Ser Val Thr Lys Cys Ser 
        835                 840                 845             


Ile Ser Lys Leu Glu Leu Ser Ala Ala Glu Gln Glu Leu Leu Leu Thr 
    850                 855                 860                 


Leu Pro Ser Leu Glu Ser Leu Glu Val Ser Gly Thr Ile Gln Ser Gln 
865                 870                 875                 880 


Asp Gln Ile Phe Pro Asn Leu Asp Lys Phe Leu Cys Leu Lys Glu Leu 
                885                 890                 895     


Ser Val Asp Leu Glu Gly Asn Ile Asn Val Phe Ser Val Ile Pro Glu 
            900                 905                 910         


Glu Phe Pro Asn Phe His His Met Glu Lys Leu Leu Ile Gln Ile Ser 
        915                 920                 925             


Ala Glu Tyr Asp Pro Ser Lys Leu Gly Trp Ser Tyr Ile Ala Thr Tyr 
    930                 935                 940                 


Arg Ser Gly Ser Ser Ala Gly Arg Lys Ser Ala Asn Pro 
945                 950                 955         


<210>  4638
<211>  4540
<212>  DNA
<213>  Homosapiens

<400>  4638
atggttgaaa tttataattt gaaattcctc cattccgact tagacaaggg agagggcact     60

gcgaaataca ccctctcagg agatggcgct ggcaccgttt ttaccattga tgaaaccaca    120

ggggacattc acgcaataag gagcctagat agagaagaaa aacctttcta cactcttcgt    180

gctcaggctg tggacataga aaccagaaag cccctggagc ctgaatcaga attcatcatc    240

aaagtgcagg atattaatga taatgagcca aagttttggg atggacctta tgttgctact    300

gtcccagaaa tgtctcctgt gggtgagtag gcaaatcaaa attctgtgag atacaatgag    360

acctcttcaa cattgacttt ttgcaggttg atgtaaacat cttatctatc atctaaaaga    420

attatttttc aattctagaa aatacagttc ttttcattta tttttgtaac ttttttgttt    480

ttctttctgc ttcattatga agataactac aggaatatat aacattagtt cctgttttcc    540

accctgtgaa tttacctgaa ttcatagaat ccttgcgtgc tttaagcaaa aaatgtattt    600

tgtattgaaa ttgattctta tctcaattcc agacacctat acagtgctgg agacacctac    660

cctacaccac gaaatgccag acagtaattc ctagatcaaa gtaaatgatc taaagcatgc    720

atcacatctg atctggaagt ggtccagaaa caggtgtgtt gcatcttttg tagctgtaaa    780

tagagattct ggaagggtga tactgtttcc ttttcagggt aaataaccca tacttgttat    840

gccatcaagc caagcagcaa atgaataatg tcatgaaaac attattagaa caaattaaca    900

aattacaatt acaattatca aattaacaat tagaatatag tagcaccatc attctaaaaa    960

tttaaatttg atataaatat acatttccat atcagcctaa atttacaaag tcctataata   1020

tgtaggatat aaggtcaata agttaagaat tccagcctta aggacaattt taaattataa   1080

tttttattcc tcagtcacca ctgctaatcc ttcaatttat ttcaaagtaa cttctggttt   1140

ttattacatt tggaagataa agcaacttat cacatgtagg ttacaactta aaattcgtgt   1200

atgagccatt gcttatattt tctaaatctg acatgaccca gggggtttct actgctccta   1260

ccaccaccca ggacatgcga tgaagattgt gcacgctacc gtgagggcag aagcaggtta   1320

gtagctgtag gagctgtcac atggatttac tataatgcac ttgaaattgt gtatgtgacc   1380

ttatcaggca tttaaggacc ataatctctc cttgacctaa gaaatcagct tgaagtaatt   1440

cacttagatt tcaaatttta atgtggatac ccaaggctgc aaatctgtta ttcagtacct   1500

gctacacttt tggggttgcc tcttttatgc actgttagaa ttgctagaaa tttagaagtc   1560

caattggaaa gaagcatatc ttgttagaaa gtattcccag aaaatgagga aggctacatt   1620

ttaactgtgt cttgatttta cagggagaaa aataaagtta atattttgag gaaaaaataa   1680

ggcttttaag atgacatgct atatagtaga caaatagttt aactcggtgc ctacttcatg   1740

tacactggat gtgttaacat gaatttatga ccttcagtga ctttttatta ccaaaacagc   1800

ttccttaaag caaacacaca cacatgcctc tacagtattg gaaaattccg tctccttaga   1860

taaaacaatt aggatttttc ttgggccaac tagaataatt agggctgcag agttggagcc   1920

tttatataag gagtttgcag ctcatatccg aagagagaaa tgtatttgga aagtcaaaag   1980

tgtaggtaag tgagaaagca gagtagtttc agcttttgca gttggagtgg gtataattta   2040

ctgtgttgtc ataagatact ggaaagatct ttggaagaat aggttcttaa agtgttttct   2100

catgtgccct tactgacatt tcccattggg ccttcaagac aactccagta aatacttaaa   2160

ttgattttca gtgcactgct ttctttcatt tttatttatt tattttgaga ctgggtcttg   2220

gtctgttgcc ctggctggag tgcaatggcc caatcttagc tcactgaagc cttaaattcc   2280

tgggctgaag agatccctcc acctgagcct ccttaatagc cagtcatgtg ccaccctgcc   2340

tagctatttg tttttgtttt tttttttttt ttttactttt tgtagagaag ggatctagct   2400

atgttgccca ggctgttctc aagtagtcct ggcctcaaat gatccctcca ccttggcttc   2460

ccagagcact gggattacag tcatgagcca ccctcctggc tccttttttt tttattttta   2520

ataacagaag ggtatttctt ttgaatgtga aattttacca catggtatga attagtccaa   2580

gtgtttttat actaaattta cataatatac acttttcaag taagtacaaa gaggtataaa   2640

cactgcttat gaattgaatg ttaaaaaata aatctctatg cattactttt gtctttcccc   2700

ataatctcac gtatacacat aaaacaaaaa acaagaagac ccagttatag ttgtggtatc   2760

tgctgtttct gccttgaaat ttccagctta cagctaagca acaactactg tgcatccaga   2820

acttacatct atgttcctag agtacttgta ccccattctc aagtgcaccc ttcttaccag   2880

gtggaaatag ttcactgctg taataatcta agaaaacatt atgtttctct ctactttttt   2940

ttctctcata taatctaggc aattctccct ctgtatcatt ttcctgagaa aactaaaata   3000

atttttaatc aagaccagat ggaactttgt atggtatatt gacagtatac caattgttgt   3060

gacgaatctt actgcctgtt gtagatatca gtgtttgaag tattccctat gaaataactt   3120

ttctgtccca ataattgaga gggctgtttc atttccaaaa aagggaagaa ttaatcaatt   3180

aaaaatacat atagtgaaat aacctgtttt gtaacataaa acataagatg aagaaatatc   3240

ggaacattga tatgaagttt aacagtaatg gattatatat ccagaaatat gaacaaataa   3300

acctgcaatg aaaatttact aatgttacta attttcactt gtgtaacgtg aacattacaa   3360

agaacatagt gtacaaaggg agaatgttgg tgggtaggat gagtcaagat ttcagaggaa   3420

aatcaatatt taagacttac agcactgtgg aatatattta attttcctaa agttgaagaa   3480

aatttcagtg aatctatgaa ttgtttaaga caaaggtcac tccgttactg acttctgcta   3540

catctaattt tccagggaag taatatttag agataaaaag cttttactct gacctccgga   3600

aattacttaa tgatccagat actcccaaag tcaaagcaaa tccttggaga caagtttgga   3660

ctttatgaat gtggacttaa ttctttaaga tcactagagc aacaataaat tacaggaatg   3720

taccctcttt atatctgatg attatgcata agtggggtgt gcagttttaa gttacttttc   3780

ctacagtgct gacaggttta gagtgttaaa tccatactca acttgtatta tcttcctctg   3840

cttgagctat gccaccttga gtcagctgat ttgactattt ataattagat acctaaccta   3900

tgatatgata tagtagatgt caatagtgac tcatcattta tgtagtaagt cttaccattt   3960

tctaagcagt agtcaggtgc catgtgatct aactaaagat ttgtatttct tattttactt   4020

aacaattaca gtaaccccaa tgcagtatta ttcactgttg gatttttttt aatgtgaaaa   4080

cttaataacc cctgtggata agaaagtaag aatgattctt aggtgcttta ggaccaaatt   4140

aatcagaatt taatatacca ctttgtctag gtgtcatggc ggctaaaata tctttgagaa   4200

agttaaactt agctttcaat ctcagatgat ctacttaaga atttggaaag tttatattat   4260

attatttgag aatggggatt cttgcttaaa cgaaacctga aggatgggca tctttcattc   4320

aatatcttaa aaagaaagtt tagctgacat ttaaataaga aaagatacac ctaaaataaa   4380

gtagaacact ggtttaataa aaatagtgaa caggtactcc cttgcctttc tatttttctc   4440

tcaactctat tttattttac atgaagtttg gggagaaatg ctaagatgaa atttttggtg   4500

gagtctttca gaggttattt aaccagagac tattttcttt                         4540


<210>  4639
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  4639

Met Val Glu Ile Tyr Asn Leu Lys Phe Leu His Ser Asp Leu Asp Lys 
1               5                   10                  15      


Gly Glu Gly Thr Ala Lys Tyr Thr Leu Ser Gly Asp Gly Ala Gly Thr 
            20                  25                  30          


Val Phe Thr Ile Asp Glu Thr Thr Gly Asp Ile His Ala Ile Arg Ser 
        35                  40                  45              


Leu Asp Arg Glu Glu Lys Pro Phe Tyr Thr Leu Arg Ala Gln Ala Val 
    50                  55                  60                  


Asp Ile Glu Thr Arg Lys Pro Leu Glu Pro Glu Ser Glu Phe Ile Ile 
65                  70                  75                  80  


Lys Val Gln Asp Ile Asn Asp Asn Glu Pro Lys Phe Trp Asp Gly Pro 
                85                  90                  95      


Tyr Val Ala Thr Val Pro Glu Met Ser Pro Val Gly Glu 
            100                 105                 


<210>  4640
<211>  4312
<212>  DNA
<213>  Homosapiens

<400>  4640
gccaccgcgc cgggcctatc atatgaattt tgagggaaca caaacatgca gtctgtagca     60

gatggtaata ggctgacata ttacacttgt tgatgtaaat ctgataggtt tctttctctc    120

caaggacagc tttttaaata tttaacagta tcaataattt ttcaggttct gtgagaattt    180

tataatttat aatttgcaga cttaatgtat aatctatttt gtcctaacaa ttacaaatat    240

attttttatt tcagattgta tatattccta ccagatggag ataattacag ctttaaaaat    300

ttttattttt tcattttatt tcacacattg acattaaatt tttatggaca cataataact    360

gtacatatat atggggtaga atgtgatgtt ttaatacatg tactcaatgt gtaatgatca    420

aatcagggta atttgcataa tgatttttct gtagggagaa aattcaaaat ctactcttct    480

ggctattttc aaatatataa tatgttattg ttaactatac tcatcctact atgcaatagg    540

acaccagaac ttattcctgg gttctacatc cgttaaggca accaaggatt ggaaatattg    600

gaaaaaaaaa ttgcgtctgt actgaacatg tacagacttt tttcttgtcc ttattcctta    660

cacaatatag tacaataact atttgcatga catttacatc ggatattatg agtgatctag    720

agttgatatg aagtatatgg gaggatgtgc aaaggtgatg tgcaaatact atgtcatttt    780

atatcaggga cttgagtatc ctttgttacc ctcaggagat cctgaaacca gtcccccatg    840

gatactgagg gctgactgta tagtcctatc ctcacggaac tttcattcta atgggggaag    900

actgactata aacaaaatat atgtaatagg tggtggtaag taccgtggag aagtaacaaa    960

cggggcaaag tgagttatac agctccattc ttagaaacct tggagtactt ttcttagttt   1020

atactcgtgg tggtttcctt ttgtctcctt tattacatgg gactctgaca tgtgcccata   1080

gctagggtga cagtaggatc tacccgatag tagggtggca gtaggatcta cccaaaaagc   1140

gtcctgctga tacaggacca aagcatcctg ttgttctcga gcctataaaa agagctaatg   1200

gtcttgcttc tcttaactgt ggcctcctac actgtgtttt ggatgattgg tgatgtcttg   1260

gatattctgt ttctttggaa ctttgaatat acaacacttt actagggaat tagcaatgga   1320

agcagagcaa agatgtacag aggaaacaat gcgtaactct gatggaattg aagtcatgag   1380

gcagcagaga gcttaaatta cagctttaaa aatttttatt ttttagaggg aatttacttg   1440

ggagtaacag cagtaatagt taacggagcc agaatgcttg agtcatataa ttgcaaagca   1500

gagttgggag caacagatgc taaagagtag ttgctgtagt tcctctttgg gtcgtaggag   1560

cagttgtcat attactatat agctactgca tgaagaagag ttcttagtga ggcctgggtg   1620

aacagctctt cttagtattc tgtgtgaccc catttgacct tttaacaaat ccctaagtaa   1680

ataaatagcc cctcaggaaa actaagtttt tctctgctgt ttttttgctt gagagagcta   1740

taactgtaat agacttatat ttctgaacat tttagtgctt gccaatattt ggtaatattt   1800

atgtttccta tatttgtaat gaacattctt cttccggtac attttttgtt aaattattgt   1860

ttgatggata aaagttcacc ttttattgta taaaattgac tgagattaat ttatacacat   1920

tgacaatggg taaatagaat ttttcagatt attaaaagct gaaggatgcc cacgtaagca   1980

aaaaaaaaaa agaaaaaacc aacaaaaata aacccaaacc cctcaaacaa tttcgaacac   2040

gaaacattct tctgatgccg gcatccctgc ttgcaggtgt gaagggggca ggaatcagcg   2100

aggtgtcctg ggctgagtcc ccggagtggg aagaggtggc aggaagggga tctgaggagg   2160

agaacagggg tcctggtggt ctgtgcttct tcccagacac gggagctgta gaggagacct   2220

ctgcagcaga tgctaggggg gccagtaggc ccaggcagtc ttgggacttg ggtctgtcct   2280

gctgtgcatc catagtgggt gctttagaaa cgggaggccc acccgaagcc cctgttgcaa   2340

gtgaggacaa agtgtgggaa ggccgtgagg gtctgcagtc cgggatggcc ttgtcctcaa   2400

cgtgcagtgc actgttgatg cgctggaatg ccgtctcttt ttccaggtgc aggtcttcag   2460

ccgtgacccg gtaccccagc tctaagggag gtggcagcat caaaggctcc cctcgcctgc   2520

gtggcagcag gggaatcttg cgtctacggg gcctagagtc ctgggatctg ggggagccac   2580

ccgttggggc gattgtctgc cctggtgctg tatctgcccc cttttcacac cgtgtgtgac   2640

ccgaagagac agcctgaggc ctgtcctcac tcactgtctt tgagtaactg agggtcagct   2700

ggcagcggga tgaggctggc cccctcctct gctttagccc cggcaagcct cccgtggagc   2760

tgtaggagct ggagatggca tttcgtttgg tgctcgagct cgtccaggat gtctgggatg   2820

tgtggttata tctgatttct gagctctggg catggaggtc tgtctgcaga ggcccgggcc   2880

tgggcacaaa gggagagggg cctccattgt cccgcagggg ccaaaatgca gaccgtgcat   2940

ccccggtgac ctcggggacc gttctctgat catcaggatt ttcttggact ctggggtcct   3000

tgtcctgctc aggcatccct gccccgctct ccttgagggc cctcaacact atcttccctg   3060

gacacaagtc tggggacagc cgggtgttgt ggaccccaaa ggggtgacta cctgctcctg   3120

ggccccacag agtccttgtg ctcagtgtag tggctgagct gggggatgcc ctggaactcg   3180

gagcacacag cactggctta ctgtggtacc tgtgcagtga aattgaagac agaatcacca   3240

ggatggaaca caggtcttgc aggatcactt gaaaccttct tagagttgtc ttgacaccag   3300

tgatgtcgag tgtccgggtg tttgtaggat ggcctgccac tcagtccagg ggcaggagca   3360

acggggagat cccacaagca aagtgaactg ggggatgggc tgaaggggct ccaggcaact   3420

gagccctact cgcaggtcct cggccttggc ccaaacagga atgaggggca cagagtgccc   3480

gggtaaccgc tcctgggagc agtggggaac tgtcggatac ttgaactctc aagagctggg   3540

ctctgagcgt cctcgtccag ctgccaactt ggccaaaggc taagccagca gattgttctg   3600

ttgccgggca acgcgacttc taaacctgag ggagtgggca tgtgagcaca taatggcacc   3660

agtgacagag cgaccataat ggatgaataa gcgcagccag gtacccgcgc aaggcacctg   3720

ctggcaatgg caggaggcgg acgtgggggg tcgtgcagta ggtactggag ggagagacgt   3780

gggcacaaag gtcgcgggag gaacaggtgc ccacaatggc tgcatatttg cccgtggatc   3840

actgaagatt cctgctctcc tgctgaggtg gagactgcag tgagctgaga tcgcaccatt   3900

gcactccagc ctgggcaacg agtgcaaaac tcagtctcca gataaaaaaa agaaaaagaa   3960

aaaaaagagg ccgggtgtgg tggcttatgc ctatgatcct agcactttgg gaggtcgggg   4020

tggacggatc acgagatcag gagttggagg ccagcctggc caacatagtg aaagcccgtc   4080

tctagtaaaa atacaaaatt tagtcagaca tggtgggcag gagagagcat gtgcagggga   4140

acatccattt ataaaaccat cagacctcat gagacttatt cactaccatg agaacagcat   4200

gggggaaact gcctccatga ttcagttatc tccacctggc cccacccttg acacatggga   4260

attgttacaa ttcaagatga gatttgggtg cggacagagc caaaccatat aa           4312


<210>  4641
<211>  194
<212>  PRT
<213>  Homosapiens

<400>  4641

Met Pro Ala Ser Leu Leu Ala Gly Val Lys Gly Ala Gly Ile Ser Glu 
1               5                   10                  15      


Val Ser Trp Ala Glu Ser Pro Glu Trp Glu Glu Val Ala Gly Arg Gly 
            20                  25                  30          


Ser Glu Glu Glu Asn Arg Gly Pro Gly Gly Leu Cys Phe Phe Pro Asp 
        35                  40                  45              


Thr Gly Ala Val Glu Glu Thr Ser Ala Ala Asp Ala Arg Gly Ala Ser 
    50                  55                  60                  


Arg Pro Arg Gln Ser Trp Asp Leu Gly Leu Ser Cys Cys Ala Ser Ile 
65                  70                  75                  80  


Val Gly Ala Leu Glu Thr Gly Gly Pro Pro Glu Ala Pro Val Ala Ser 
                85                  90                  95      


Glu Asp Lys Val Trp Glu Gly Arg Glu Gly Leu Gln Ser Gly Met Ala 
            100                 105                 110         


Leu Ser Ser Thr Cys Ser Ala Leu Leu Met Arg Trp Asn Ala Val Ser 
        115                 120                 125             


Phe Ser Arg Cys Arg Ser Ser Ala Val Thr Arg Tyr Pro Ser Ser Lys 
    130                 135                 140                 


Gly Gly Gly Ser Ile Lys Gly Ser Pro Arg Leu Arg Gly Ser Arg Gly 
145                 150                 155                 160 


Ile Leu Arg Leu Arg Gly Leu Glu Ser Trp Asp Leu Gly Glu Pro Pro 
                165                 170                 175     


Val Gly Ala Ile Val Cys Pro Gly Ala Val Ser Ala Pro Phe Ser His 
            180                 185                 190         


Arg Val 
        


<210>  4642
<211>  1584
<212>  DNA
<213>  Homosapiens

<400>  4642
ttttctgccc atggacaccg ccgaagaagc attgttaaag tctctcttca ccctgccgtc     60

atgtctaagt cagagtctcc tgaagagccc gaacagctga ggaagctctt cattggaggg    120

ctgagctttg aaacaactga tgagagcctt gaggagccat tttgagcaat ggggaatgct    180

cacggactgt gtggtcatga gagatccaaa caccaagcac cccaggggct ttgggtttgt    240

cacatatgct actgtggagg aggtggatgc agccatgaat gcaaggccac acaaggtgga    300

tggaagagtt gtggaaccaa agagagctgt ctcgagagaa gattctgaaa gaccaggtgc    360

ccacttaact gtgaaaaaga tatttgttgg tggcattaaa gaagacactg aagaacatca    420

cctaagagat gattttgaac agtatggaaa aattgaagtg attgaaatca tgactgaccg    480

aggcagtggc aagaaaaggg gctttgcctt tgtaaatttt gacgaccatg actccatgga    540

taagattgtc attcagaaat accatactgt gaatggccac aactgtgaag ttaggaaagc    600

cccgtcacag caagagatgg atagtgcttc atccagccaa agaggtcgaa gtggttctgg    660

aaactttggt ggtggaagct acaatgattt tggcaattac aacaatcagt cttcaaattt    720

tggacccatg aagggaggaa attttggagg cagaagctct ggcccttatg gtggtggagg    780

ccaatacttt gcaaaaccac aaaaccaagg tggctatggc ggttccagta gcagcggtag    840

ctatggcagt ggcagaagat tttaattagg aaacaaagct tagcaggagc ggagagccag    900

agaagtgaca gggaagctac aggttacaac agatttgtga actcagccaa gcacagtggt    960

ggcagggcct agctgctaca aagaagacat gttttagaca aatactcatg tgtatgggca   1020

aaaaactcga ggactgtatt tgtgactaat tgtataacag gttattttag tttctgttct   1080

gtggaaagtg taaagcattc caacaaaggg ttttaatgta gatttttttt ttgcacctat   1140

gctgttgatt gctaatgtaa tagtctgatc gtgatgctga ataaatgtct tttcttttta   1200

atgtgctgtg taaagttagt ctactctgaa gccatcttgg taaatttccc caacagtgtg   1260

aagttagaat tccttcaggg tgatgccagg ttctatttgg aatttatata caacctgctt   1320

ggagggagaa gccattgtct tcagaaacct tggtgtagtt gaactgatag ttaccgttgt   1380

gacctgaagt tcaccattaa aagggattac ccaagcaaaa tcatggaatt attggttata   1440

aaagtgattg ttggcacatc ctatgcaata tatctaaatt gaataatggt actagataaa   1500

attatagatg ggaatgaagc ttgtgtatca tccattatca tgtgtaatca ataaatgatt   1560

taattctctt gaaaaaaaca agga                                          1584


<210>  4643
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  4643

Met Leu Thr Asp Cys Val Val Met Arg Asp Pro Asn Thr Lys His Pro 
1               5                   10                  15      


Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr Val Glu Glu Val Asp Ala 
            20                  25                  30          


Ala Met Asn Ala Arg Pro His Lys Val Asp Gly Arg Val Val Glu Pro 
        35                  40                  45              


Lys Arg Ala Val Ser Arg Glu Asp Ser Glu Arg Pro Gly Ala His Leu 
    50                  55                  60                  


Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu 
65                  70                  75                  80  


His His Leu Arg Asp Asp Phe Glu Gln Tyr Gly Lys Ile Glu Val Ile 
                85                  90                  95      


Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys Arg Gly Phe Ala Phe 
            100                 105                 110         


Val Asn Phe Asp Asp His Asp Ser Met Asp Lys Ile Val Ile Gln Lys 
        115                 120                 125             


Tyr His Thr Val Asn Gly His Asn Cys Glu Val Arg Lys Ala Pro Ser 
    130                 135                 140                 


Gln Gln Glu Met Asp Ser Ala Ser Ser Ser Gln Arg Gly Arg Ser Gly 
145                 150                 155                 160 


Ser Gly Asn Phe Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn 
                165                 170                 175     


Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
            180                 185                 190         


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
        195                 200                 205             


Gln Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Gly Ser Tyr Gly 
    210                 215                 220                 


Ser Gly Arg Arg Phe 
225                 


<210>  4644
<211>  1351
<212>  DNA
<213>  Homosapiens

<400>  4644
ttttctgccc atggacaccg ccgaagaagc attgttaaag tctctcttca ccctgccgtc     60

atgtctaagt cagagtctcc tgaagagccc gaacagctga ggaagctctt cattggaggg    120

ctgagctttg aaacaactga tgagagcctt gaggagccat tttgagcaat ggggaatgct    180

cacggactgt gtggtcatga gagatccaaa caccaagcac cccaggggct ttgggtttgt    240

cacatatgct actgtggagg aggtggatgc agccatgaat gcaaggccac acaaggtgga    300

tggaagagtt gtggaaccaa agagagctgt ctcgagagaa gattctgaaa gaccaggtgc    360

ccacttaact gtgaaaaaga tatttgttgg tggcattaaa gaagacactg aagaacatca    420

cctaagagat gattttgaac agtatggaaa aattgaagtg attgaaatca tgactgaccg    480

aggcagtggc aagaaaaggg gctttgcctt tgtaaatttt gacgaccatg actccatgga    540

taagattgtc attcagaaat accatactgt gaatggccac aactgtgaag ttaggaaagc    600

cccgtcacag caagagatgg atagtgcttc atccagccaa agaggtcgaa gtggttctgg    660

aaactttggt ggtggtcgtg gaggtggttt cggtgggaat gacaactttg gtcatggagg    720

aaacttcagt ggttgtggtg gctttggtgg cagtcatggt ggtggtggat atggtggcag    780

tggggatggc tataatggat ttggtaatga tggaagcgat tttggaggtg gtggaagcta    840

caatgatttt ggcaattaca acaatcagtc ttcaaatttt ggacccatga agggaggaaa    900

ttttggaggc agaagctctg gcccttatgg tggtggaggc caatactttg caaaaccaca    960

aaaccaaggt ggctatggcg gttccagtag cagcggtagc tatggcagtg gcagaagatt   1020

ttaattagga aacaaagctt agcaggagcg gagagccaga gaagtgacag ggaagctaca   1080

ggttacaaca gatttgtgaa ctcagccaag cacagtggtg gcagggccta gctgctacaa   1140

agaagacatg ttttagacaa atactcatgt gtatgggcaa aaaactcgag gactgtattt   1200

gtgactaatt gtataacagg ttattttagt ttctgttctg tggaaagtgt aaagcattcc   1260

aacaaagggt tttaatgtag attttttttt tgcacctatg ctgttgattg ctaatgtaat   1320

agtctgatcg tgatgctgaa taaatgtctt t                                  1351


<210>  4645
<211>  282
<212>  PRT
<213>  Homosapiens

<400>  4645

Met Leu Thr Asp Cys Val Val Met Arg Asp Pro Asn Thr Lys His Pro 
1               5                   10                  15      


Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr Val Glu Glu Val Asp Ala 
            20                  25                  30          


Ala Met Asn Ala Arg Pro His Lys Val Asp Gly Arg Val Val Glu Pro 
        35                  40                  45              


Lys Arg Ala Val Ser Arg Glu Asp Ser Glu Arg Pro Gly Ala His Leu 
    50                  55                  60                  


Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu 
65                  70                  75                  80  


His His Leu Arg Asp Asp Phe Glu Gln Tyr Gly Lys Ile Glu Val Ile 
                85                  90                  95      


Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys Arg Gly Phe Ala Phe 
            100                 105                 110         


Val Asn Phe Asp Asp His Asp Ser Met Asp Lys Ile Val Ile Gln Lys 
        115                 120                 125             


Tyr His Thr Val Asn Gly His Asn Cys Glu Val Arg Lys Ala Pro Ser 
    130                 135                 140                 


Gln Gln Glu Met Asp Ser Ala Ser Ser Ser Gln Arg Gly Arg Ser Gly 
145                 150                 155                 160 


Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly Asn Asp 
                165                 170                 175     


Asn Phe Gly His Gly Gly Asn Phe Ser Gly Cys Gly Gly Phe Gly Gly 
            180                 185                 190         


Ser His Gly Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr Asn Gly 
        195                 200                 205             


Phe Gly Asn Asp Gly Ser Asp Phe Gly Gly Gly Gly Ser Tyr Asn Asp 
    210                 215                 220                 


Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly 
225                 230                 235                 240 


Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln 
                245                 250                 255     


Tyr Phe Ala Lys Pro Gln Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser 
            260                 265                 270         


Ser Gly Ser Tyr Gly Ser Gly Arg Arg Phe 
        275                 280         


<210>  4646
<211>  1588
<212>  DNA
<213>  Homosapiens

<400>  4646
cccatggaca ccgccgaaga agcattgtta aagtctctct tcaccctgcc gtcatgtcta     60

agtcagagtc tcctgaagag cccgaacagc tgaggaagct cttcattgga gggctgagct    120

ttgaaacaac tgatgagagc cttgaggagc cattttgagc aatggggaat gctcacggac    180

tgtgtgattc tgaaagacca ggtgcccact taactgtgaa aaagatattt gttggtggca    240

ttaaagaaga cactgaagaa catcacctaa gagatgattt tgaacagtat ggaaaaattg    300

aagtgattga aatcatgact gaccgaggca gtggcaagaa aaggggcttt gcctttgtaa    360

attttgacga ccatgactcc atggataaga ttgtcattca gaaataccat actgtgaatg    420

gccacaactg tgaagttagg aaagccccgt cacagcaaga gatggatagt gcttcatcca    480

gccaaagagg tcgaagtggt tctggaaact ttggtggtgg tcgtggaggt ggtttcggtg    540

ggaatgacaa ctttggtcat ggaggaaact tcagtggttg tggtggcttt ggtggcagtc    600

atggtggtgg tggatatggt ggcagtgggg atggctataa tggatttggt aatgatggaa    660

gcgattttgg aggtggtgga agctacaatg attttggcaa ttacaacaat cagtcttcaa    720

attttggacc catgaaggga ggaaattttg gaggcagaag ctctggccct tatggtggtg    780

gaggccaata ctttgcaaaa ccacaaaacc aaggtggcta tggcggttcc agtagcagcg    840

gtagctatgg cagtggcaga agattttaat taggaaacaa agcttagcag gagcggagag    900

ccagagaagt gacagggaag ctacaggtta caacagattt gtgaactcag ccaagcacag    960

tggtggcagg gcctagctgc tacaaagaag acatgtttta gacaaatact catgtgtatg   1020

ggcaaaaaac tcgaggactg tatttgtgac taattgtata acaggttatt ttagtttctg   1080

ttctgtggaa agtgtaaagc attccaacaa agggttttaa tgtagatttt ttttttgcac   1140

ctatgctgtt gattgctaat gtaatagtct gatcgtgatg ctgaataaat gtcttttctt   1200

tttaatgtgc tgtgtaaagt tagtctactc tgaagccatc ttggtaaatt tccccaacag   1260

tgtgaagtta gaattccttc agggtgatgc caggttctat ttggaattta tatacaacct   1320

gcttggaggg agaagccatt gtcttcagaa accttggtgt agttgaactg atagttaccg   1380

ttgtgacctg aagttcacca ttaaaaggga ttacccaagc aaaatcatgg aattattggt   1440

tataaaagtg attgttggca catcctatgc aatatatcta aattgaataa tggtactaga   1500

taaaattata gatgggaatg aagcttgtgt atcatccatt atcatgtgta atcaataaat   1560

gatttaattc tcttgaaaaa aacaagga                                      1588


<210>  4647
<211>  235
<212>  PRT
<213>  Homosapiens

<400>  4647

Met Gly Asn Ala His Gly Leu Cys Asp Ser Glu Arg Pro Gly Ala His 
1               5                   10                  15      


Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys Glu Asp Thr Glu 
            20                  25                  30          


Glu His His Leu Arg Asp Asp Phe Glu Gln Tyr Gly Lys Ile Glu Val 
        35                  40                  45              


Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys Arg Gly Phe Ala 
    50                  55                  60                  


Phe Val Asn Phe Asp Asp His Asp Ser Met Asp Lys Ile Val Ile Gln 
65                  70                  75                  80  


Lys Tyr His Thr Val Asn Gly His Asn Cys Glu Val Arg Lys Ala Pro 
                85                  90                  95      


Ser Gln Gln Glu Met Asp Ser Ala Ser Ser Ser Gln Arg Gly Arg Ser 
            100                 105                 110         


Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly Asn 
        115                 120                 125             


Asp Asn Phe Gly His Gly Gly Asn Phe Ser Gly Cys Gly Gly Phe Gly 
    130                 135                 140                 


Gly Ser His Gly Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr Asn 
145                 150                 155                 160 


Gly Phe Gly Asn Asp Gly Ser Asp Phe Gly Gly Gly Gly Ser Tyr Asn 
                165                 170                 175     


Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys 
            180                 185                 190         


Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly 
        195                 200                 205             


Gln Tyr Phe Ala Lys Pro Gln Asn Gln Gly Gly Tyr Gly Gly Ser Ser 
    210                 215                 220                 


Ser Ser Gly Ser Tyr Gly Ser Gly Arg Arg Phe 
225                 230                 235 


<210>  4648
<211>  1743
<212>  DNA
<213>  Homosapiens

<400>  4648
ttttctgccc atggacaccg ccgaagaagc attgttaaag tctctcttca ccctgccgtc     60

atgtctaagt cagagtctcc tgaagagccc gaacagctga ggaagctctt cattggaggg    120

ctgagctttg aaacaactga tgagagcctt gaggagccat tttgagcaat ggggaatgct    180

cacggactgt gtggtcatga gagatccaaa caccaagcac cccaggggct ttgggtttgt    240

cacatatgct actgtggagg aggtggatgc agccatgaat gcaaggccac acaaggtgga    300

tggaagagtt gtggaaccaa agagagctgt ctcgagagaa gattctgaaa gaccaggtgc    360

ccacttaact gtgaaaaaga tatttgttgg tggcattaaa gaagacactg aagaacatca    420

cctaagagat gattttgaac agtatggaaa aattgaagtg attgaaatca tgactgaccg    480

aggcagtggc aagaaaaggg gctttgcctt tgtaaatttt gacgaccatg actccatgga    540

taagattgtc attcagaaat accatactgt gaatggccac aactgtgaag ttaggaaagc    600

cccgtcacag caagagatgg atagtgcttc atccagccaa agaggtcgaa gtggttctgg    660

aaactttggt ggtggtcgtg gaggtggttt cggtgggaat gacaactttg gtcatggagg    720

aaacttcagt ggttgtggtg gctttggtgg cagtcatggt ggtggtggat atggtggcag    780

tggggatggc tataatggat ttggtaatga tggaagcgat tttggaggtg gtggaagcta    840

caatgatttt ggcaattaca acaatcagtc ttcaaatttt ggacccatga agggaggaaa    900

ttttggaggc agaagctctg gcccttatgg tggtggaggc caatactttg caaaaccaca    960

aaaccaaggt ggctatggcg gttccagtag cagcggtagc tatggcagtg gcagaagatt   1020

ttaattagga aacaaagctt agcaggagcg gagagccaga gaagtgacag ggaagctaca   1080

ggttacaaca gatttgtgaa ctcagccaag cacagtggtg gcagggccta gctgctacaa   1140

agaagacatg ttttagacaa atactcatgt gtatgggcaa aaaactcgag gactgtattt   1200

gtgactaatt gtataacagg ttattttagt ttctgttctg tggaaagtgt aaagcattcc   1260

aacaaagggt tttaatgtag attttttttt tgcacctatg ctgttgattg ctaatgtaat   1320

agtctgatcg tgatgctgaa taaatgtctt ttctttttaa tgtgctgtgt aaagttagtc   1380

tactctgaag ccatcttggt aaatttcccc aacagtgtga agttagaatt ccttcagggt   1440

gatgccaggt tctatttgga atttatatac aacctgcttg gagggagaag ccattgtctt   1500

cagaaacctt ggtgtagttg aactgatagt taccgttgtg acctgaagtt caccattaaa   1560

agggattacc caagcaaaat catggaatta ttggttataa aagtgattgt tggcacatcc   1620

tatgcaatat atctaaattg aataatggta ctagataaaa ttatagatgg gaatgaagct   1680

tgtgtatcat ccattatcat gtgtaatcaa taaatgattt aattctcttg aaaaaaacaa   1740

gga                                                                 1743


<210>  4649
<211>  282
<212>  PRT
<213>  Homosapiens

<400>  4649

Met Leu Thr Asp Cys Val Val Met Arg Asp Pro Asn Thr Lys His Pro 
1               5                   10                  15      


Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr Val Glu Glu Val Asp Ala 
            20                  25                  30          


Ala Met Asn Ala Arg Pro His Lys Val Asp Gly Arg Val Val Glu Pro 
        35                  40                  45              


Lys Arg Ala Val Ser Arg Glu Asp Ser Glu Arg Pro Gly Ala His Leu 
    50                  55                  60                  


Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu 
65                  70                  75                  80  


His His Leu Arg Asp Asp Phe Glu Gln Tyr Gly Lys Ile Glu Val Ile 
                85                  90                  95      


Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys Arg Gly Phe Ala Phe 
            100                 105                 110         


Val Asn Phe Asp Asp His Asp Ser Met Asp Lys Ile Val Ile Gln Lys 
        115                 120                 125             


Tyr His Thr Val Asn Gly His Asn Cys Glu Val Arg Lys Ala Pro Ser 
    130                 135                 140                 


Gln Gln Glu Met Asp Ser Ala Ser Ser Ser Gln Arg Gly Arg Ser Gly 
145                 150                 155                 160 


Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly Asn Asp 
                165                 170                 175     


Asn Phe Gly His Gly Gly Asn Phe Ser Gly Cys Gly Gly Phe Gly Gly 
            180                 185                 190         


Ser His Gly Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr Asn Gly 
        195                 200                 205             


Phe Gly Asn Asp Gly Ser Asp Phe Gly Gly Gly Gly Ser Tyr Asn Asp 
    210                 215                 220                 


Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly 
225                 230                 235                 240 


Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln 
                245                 250                 255     


Tyr Phe Ala Lys Pro Gln Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser 
            260                 265                 270         


Ser Gly Ser Tyr Gly Ser Gly Arg Arg Phe 
        275                 280         


<210>  4650
<211>  1704
<212>  DNA
<213>  Homosapiens

<400>  4650
ttttctgccc atggacaccg ccgaagaagc attgttaaag tctctcttca ccctgccgtc     60

atgtctaagt cagagtctcc tgaagagccc gaacagctga ggaagctctt cattggaggg    120

ctgagctttg aaacaactga tgagagcctt gaggagccat tttgagcaat ggggaatgct    180

cacggactgt gtggtcatga gagatccaaa caccaagcac cccaggggct ttgggtttgt    240

cacatatgct actgtggagg aggtggatgc agccatgaat gcaaggccac acaaggtgga    300

tggaagagtt gtggaaccaa agagagctgt ctcgagagaa gattctgaaa gaccaggtgc    360

ccacttaact gtgaaaaaga tatttgttgg tggcattaaa gaagacactg aagaacatca    420

cctaagagat gattttgaac agtatggaaa aattgaagtg attgaaatca tgactgaccg    480

aggcagtggc aagaaaaggg gctttgcctt tgtaaatttt gacgaccatg actccatgga    540

taagattgtc attcagaaat accatactgt gaatggccac aactgtgaag ttaggaaagc    600

cccgtcacag caagagatgg atagtgcttc atccagccaa agaggtcgaa gtggttctgg    660

aaactttggt ggtggtcgtg gaggtggttt cggtgggaat gacaactttg gtcatggagg    720

aaacttcagt ggttgtggta gtggggatgg ctataatgga tttggtaatg atggaagcga    780

ttttggaggt ggtggaagct acaatgattt tggcaattac aacaatcagt cttcaaattt    840

tggacccatg aagggaggaa attttggagg cagaagctct ggcccttatg gtggtggagg    900

ccaatacttt gcaaaaccac aaaaccaagg tggctatggc ggttccagta gcagcggtag    960

ctatggcagt ggcagaagat tttaattagg aaacaaagct tagcaggagc ggagagccag   1020

agaagtgaca gggaagctac aggttacaac agatttgtga actcagccaa gcacagtggt   1080

ggcagggcct agctgctaca aagaagacat gttttagaca aatactcatg tgtatgggca   1140

aaaaactcga ggactgtatt tgtgactaat tgtataacag gttattttag tttctgttct   1200

gtggaaagtg taaagcattc caacaaaggg ttttaatgta gatttttttt ttgcacctat   1260

gctgttgatt gctaatgtaa tagtctgatc gtgatgctga ataaatgtct tttcttttta   1320

atgtgctgtg taaagttagt ctactctgaa gccatcttgg taaatttccc caacagtgtg   1380

aagttagaat tccttcaggg tgatgccagg ttctatttgg aatttatata caacctgctt   1440

ggagggagaa gccattgtct tcagaaacct tggtgtagtt gaactgatag ttaccgttgt   1500

gacctgaagt tcaccattaa aagggattac ccaagcaaaa tcatggaatt attggttata   1560

aaagtgattg ttggcacatc ctatgcaata tatctaaatt gaataatggt actagataaa   1620

attatagatg ggaatgaagc ttgtgtatca tccattatca tgtgtaatca ataaatgatt   1680

taattctctt gaaaaaaaca agga                                          1704


<210>  4651
<211>  269
<212>  PRT
<213>  Homosapiens

<400>  4651

Met Leu Thr Asp Cys Val Val Met Arg Asp Pro Asn Thr Lys His Pro 
1               5                   10                  15      


Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr Val Glu Glu Val Asp Ala 
            20                  25                  30          


Ala Met Asn Ala Arg Pro His Lys Val Asp Gly Arg Val Val Glu Pro 
        35                  40                  45              


Lys Arg Ala Val Ser Arg Glu Asp Ser Glu Arg Pro Gly Ala His Leu 
    50                  55                  60                  


Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu 
65                  70                  75                  80  


His His Leu Arg Asp Asp Phe Glu Gln Tyr Gly Lys Ile Glu Val Ile 
                85                  90                  95      


Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys Arg Gly Phe Ala Phe 
            100                 105                 110         


Val Asn Phe Asp Asp His Asp Ser Met Asp Lys Ile Val Ile Gln Lys 
        115                 120                 125             


Tyr His Thr Val Asn Gly His Asn Cys Glu Val Arg Lys Ala Pro Ser 
    130                 135                 140                 


Gln Gln Glu Met Asp Ser Ala Ser Ser Ser Gln Arg Gly Arg Ser Gly 
145                 150                 155                 160 


Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly Asn Asp 
                165                 170                 175     


Asn Phe Gly His Gly Gly Asn Phe Ser Gly Cys Gly Ser Gly Asp Gly 
            180                 185                 190         


Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asp Phe Gly Gly Gly Gly Ser 
        195                 200                 205             


Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro 
    210                 215                 220                 


Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly 
225                 230                 235                 240 


Gly Gly Gln Tyr Phe Ala Lys Pro Gln Asn Gln Gly Gly Tyr Gly Gly 
                245                 250                 255     


Ser Ser Ser Ser Gly Ser Tyr Gly Ser Gly Arg Arg Phe 
            260                 265                 


<210>  4652
<211>  1666
<212>  DNA
<213>  Homosapiens

<400>  4652
ttttctgccc atggacaccg ccgaagaagc attgttaaag tctctcttca ccctgccgtc     60

atgtctaagt cagagtctcc tgaagagccc gaacagctga ggaagctctt cattggaggg    120

ctgagctttg aaacaactga tgagagcctt gaggagccat tttgagcaat ggggaatgct    180

cacggactgt gtggtcatga gagatccaaa caccaagcac cccaggggct ttgggtttgt    240

cacatatgct actgtggagg aggtggatgc agccatgaat gcaaggccac acaaggtgga    300

tggaagagtt gtggaaccaa agagagctgt ctcgagagaa gattctgaaa gaccaggtgc    360

ccacttaact gtgaaaaaga tatttgttgg tggcattaaa gaagacactg aagaacatca    420

cctaagagat gattttgaac agtatggaaa aattgaagtg attgaaatca tgactgaccg    480

aggcagtggc aagaaaaggg gctttgcctt tgtaaatttt gacgaccatg actccatgga    540

taagattgtc attcagaaat accatactgt gaatggccac aactgtgaag ttaggaaagc    600

cccgtcacag caagagatgg atagtgcttc atccagccaa agaggtcgaa gtggttctgg    660

aaactttggt ggtggtcgtg gaggtggttt cggtgggaat gacaactttg gtcatggagg    720

aaacttcagt ggttgtggtg gctttggtgg cagtcatggt ggtggtggat atggtggcag    780

tggggatggc tataatggat ttggtaatga tggaagcgat tttggaggtg gtggaagcta    840

caatgatttt ggcaattaca acaatcagtc ttcaaatttt ggacccatga agggaggaaa    900

ttttggaggc agaagctctg gcccttatgg tggtggaggc caatactttg caaaaccaca    960

aaaccaagga gcggagagcc agagaagtga cagggaagct acaggttaca acagatttgt   1020

gaactcagcc aagcacagtg gtggcagggc ctagctgcta caaagaagac atgttttaga   1080

caaatactca tgtgtatggg caaaaaactc gaggactgta tttgtgacta attgtataac   1140

aggttatttt agtttctgtt ctgtggaaag tgtaaagcat tccaacaaag ggttttaatg   1200

tagatttttt ttttgcacct atgctgttga ttgctaatgt aatagtctga tcgtgatgct   1260

gaataaatgt cttttctttt taatgtgctg tgtaaagtta gtctactctg aagccatctt   1320

ggtaaatttc cccaacagtg tgaagttaga attccttcag ggtgatgcca ggttctattt   1380

ggaatttata tacaacctgc ttggagggag aagccattgt cttcagaaac cttggtgtag   1440

ttgaactgat agttaccgtt gtgacctgaa gttcaccatt aaaagggatt acccaagcaa   1500

aatcatggaa ttattggtta taaaagtgat tgttggcaca tcctatgcaa tatatctaaa   1560

ttgaataatg gtactagata aaattataga tgggaatgaa gcttgtgtat catccattat   1620

catgtgtaat caataaatga tttaattctc ttgaaaaaaa caagga                  1666


<210>  4653
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  4653

Met Leu Thr Asp Cys Val Val Met Arg Asp Pro Asn Thr Lys His Pro 
1               5                   10                  15      


Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr Val Glu Glu Val Asp Ala 
            20                  25                  30          


Ala Met Asn Ala Arg Pro His Lys Val Asp Gly Arg Val Val Glu Pro 
        35                  40                  45              


Lys Arg Ala Val Ser Arg Glu Asp Ser Glu Arg Pro Gly Ala His Leu 
    50                  55                  60                  


Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu 
65                  70                  75                  80  


His His Leu Arg Asp Asp Phe Glu Gln Tyr Gly Lys Ile Glu Val Ile 
                85                  90                  95      


Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys Arg Gly Phe Ala Phe 
            100                 105                 110         


Val Asn Phe Asp Asp His Asp Ser Met Asp Lys Ile Val Ile Gln Lys 
        115                 120                 125             


Tyr His Thr Val Asn Gly His Asn Cys Glu Val Arg Lys Ala Pro Ser 
    130                 135                 140                 


Gln Gln Glu Met Asp Ser Ala Ser Ser Ser Gln Arg Gly Arg Ser Gly 
145                 150                 155                 160 


Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly Asn Asp 
                165                 170                 175     


Asn Phe Gly His Gly Gly Asn Phe Ser Gly Cys Gly Gly Phe Gly Gly 
            180                 185                 190         


Ser His Gly Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr Asn Gly 
        195                 200                 205             


Phe Gly Asn Asp Gly Ser Asp Phe Gly Gly Gly Gly Ser Tyr Asn Asp 
    210                 215                 220                 


Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly 
225                 230                 235                 240 


Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln 
                245                 250                 255     


Tyr Phe Ala Lys Pro Gln Asn Gln Gly Ala Glu Ser Gln Arg Ser Asp 
            260                 265                 270         


Arg Glu Ala Thr Gly Tyr Asn Arg Phe Val Asn Ser Ala Lys His Ser 
        275                 280                 285             


Gly Gly Arg Ala 
    290         


<210>  4654
<211>  1683
<212>  DNA
<213>  Homosapiens

<400>  4654
ttttctgccc atggacaccg ccgaagaagc attgttaaag tctctcttca ccctgccgtc     60

atgtctaagt cagagtctcc tgaagagccc gaacagctga ggaagctctt cattggaggg    120

ctgagctttg aaacaactga tgagagcctt gaggagccat tttgagcaat ggggaatgct    180

cacggactgt gtggtcatga gagatccaaa caccaagcac cccaggggct ttgggtttgt    240

cacatatgct actgtggagg aggtggatgc agccatgaat gcaaggccac acaaggtgga    300

tggaagagtt gtggaaccaa agagagctgt ctcgagagaa gattctgaaa gaccaggtgc    360

ccacttaact gtgaaaaaga tatttgttgg tggcattaaa gaagacactg aagaacatca    420

cctaagagat gattttgaac agtatggaaa aattgaagtg attgaaatca tgactgaccg    480

aggcagtggc aagaaaaggg gctttgcctt tgtaaatttt gacgaccatg actccatgga    540

taagattgtc attcagaaat accatactgt gaatggccac aactgtgaag ttaggaaagc    600

cccgtcacag caagagatgg atagtgcttc atccagccaa agaggtcgaa gtggttctgg    660

aaactttggt ggtggtcgtg gaggtggttt cggtgggaat gacaactttg gtcatggagg    720

aaacttcagt ggttgtggtg gctttggtgg cagtcatggt ggtggtggat atggtggcag    780

tggggatggc tataatggat ttggtaatga tggaagcgat tttggaggtg gtggaagcta    840

caatgatttt ggcaattaca acaatcagtc ttcaaatttt ggacccatga agggaggaaa    900

ttttggaggc agaagctctg gcccttatgg tggtggaggc caatactttg caaaaccaca    960

aaaccaagga aacaaagctt agcaggagcg gagagccaga gaagtgacag ggaagctaca   1020

ggttacaaca gatttgtgaa ctcagccaag cacagtggtg gcagggccta gctgctacaa   1080

agaagacatg ttttagacaa atactcatgt gtatgggcaa aaaactcgag gactgtattt   1140

gtgactaatt gtataacagg ttattttagt ttctgttctg tggaaagtgt aaagcattcc   1200

aacaaagggt tttaatgtag attttttttt tgcacctatg ctgttgattg ctaatgtaat   1260

agtctgatcg tgatgctgaa taaatgtctt ttctttttaa tgtgctgtgt aaagttagtc   1320

tactctgaag ccatcttggt aaatttcccc aacagtgtga agttagaatt ccttcagggt   1380

gatgccaggt tctatttgga atttatatac aacctgcttg gagggagaag ccattgtctt   1440

cagaaacctt ggtgtagttg aactgatagt taccgttgtg acctgaagtt caccattaaa   1500

agggattacc caagcaaaat catggaatta ttggttataa aagtgattgt tggcacatcc   1560

tatgcaatat atctaaattg aataatggta ctagataaaa ttatagatgg gaatgaagct   1620

tgtgtatcat ccattatcat gtgtaatcaa taaatgattt aattctcttg aaaaaaacaa   1680

gga                                                                 1683


<210>  4655
<211>  268
<212>  PRT
<213>  Homosapiens

<400>  4655

Met Leu Thr Asp Cys Val Val Met Arg Asp Pro Asn Thr Lys His Pro 
1               5                   10                  15      


Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr Val Glu Glu Val Asp Ala 
            20                  25                  30          


Ala Met Asn Ala Arg Pro His Lys Val Asp Gly Arg Val Val Glu Pro 
        35                  40                  45              


Lys Arg Ala Val Ser Arg Glu Asp Ser Glu Arg Pro Gly Ala His Leu 
    50                  55                  60                  


Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu 
65                  70                  75                  80  


His His Leu Arg Asp Asp Phe Glu Gln Tyr Gly Lys Ile Glu Val Ile 
                85                  90                  95      


Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys Arg Gly Phe Ala Phe 
            100                 105                 110         


Val Asn Phe Asp Asp His Asp Ser Met Asp Lys Ile Val Ile Gln Lys 
        115                 120                 125             


Tyr His Thr Val Asn Gly His Asn Cys Glu Val Arg Lys Ala Pro Ser 
    130                 135                 140                 


Gln Gln Glu Met Asp Ser Ala Ser Ser Ser Gln Arg Gly Arg Ser Gly 
145                 150                 155                 160 


Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly Asn Asp 
                165                 170                 175     


Asn Phe Gly His Gly Gly Asn Phe Ser Gly Cys Gly Gly Phe Gly Gly 
            180                 185                 190         


Ser His Gly Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr Asn Gly 
        195                 200                 205             


Phe Gly Asn Asp Gly Ser Asp Phe Gly Gly Gly Gly Ser Tyr Asn Asp 
    210                 215                 220                 


Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly 
225                 230                 235                 240 


Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln 
                245                 250                 255     


Tyr Phe Ala Lys Pro Gln Asn Gln Gly Asn Lys Ala 
            260                 265             


<210>  4656
<211>  513
<212>  DNA
<213>  Homosapiens

<400>  4656
atggaaggcc ctacccctgt ctcagcccta ctccactcaa gcaccatagt tgtagctggg     60

gtctttctac tcatccgctt ccacccccta gcagaaaata gcccgccaac ccaaaccctc    120

acactatgtt taggcgctat aactacccta ctcgcagcag tctgcgccct cacacaaaat    180

gatatcaaaa aaatcgtggc cttctctact tcaagccaat tgggactcat aatagtcaca    240

atcggcatca accagccata cctagcattc ctacacatct gtacccacgc cttcttcaaa    300

gccatgctat ttgtatgctc cggatccatt atccataacc tcaacaatga acaagacatt    360

cgaaaaatag gaggactact caaaactata cccctcactt caacctccct caccattggc    420

agcctagcac ttgcaggaat accctttctc acaggtttct actccaaaga cctcatcatc    480

gaaaccacaa acatatcata caccaacgcc tga                                 513


<210>  4657
<211>  170
<212>  PRT
<213>  Homosapiens

<400>  4657

Met Glu Gly Pro Thr Pro Val Ser Ala Leu Leu His Ser Ser Thr Ile 
1               5                   10                  15      


Val Val Ala Gly Val Phe Leu Leu Ile Arg Phe His Pro Leu Ala Glu 
            20                  25                  30          


Asn Ser Pro Pro Thr Gln Thr Leu Thr Leu Cys Leu Gly Ala Ile Thr 
        35                  40                  45              


Thr Leu Leu Ala Ala Val Cys Ala Leu Thr Gln Asn Asp Ile Lys Lys 
    50                  55                  60                  


Ile Val Ala Phe Ser Thr Ser Ser Gln Leu Gly Leu Ile Ile Val Thr 
65                  70                  75                  80  


Ile Gly Ile Asn Gln Pro Tyr Leu Ala Phe Leu His Ile Cys Thr His 
                85                  90                  95      


Ala Phe Phe Lys Ala Met Leu Phe Val Cys Ser Gly Ser Ile Ile His 
            100                 105                 110         


Asn Leu Asn Asn Glu Gln Asp Ile Arg Lys Ile Gly Gly Leu Leu Lys 
        115                 120                 125             


Thr Ile Pro Leu Thr Ser Thr Ser Leu Thr Ile Gly Ser Leu Ala Leu 
    130                 135                 140                 


Ala Gly Ile Pro Phe Leu Thr Gly Phe Tyr Ser Lys Asp Leu Ile Ile 
145                 150                 155                 160 


Glu Thr Thr Asn Ile Ser Tyr Thr Asn Ala 
                165                 170 


<210>  4658
<211>  706
<212>  DNA
<213>  Homosapiens

<400>  4658
atgtccctcc ctaagccctg gtctctcttg cctcctgcag ggctggtgaa ttaccagatc     60

tccgtcaagt gcagtaacca gttcaagttg gaagtgtgtc ttttgaatgc agaaaacaag    120

gtcgtggaca accaggctgg gacccagggc cagctgaagg tgctgggtgc caacctctgg    180

tggccatacc tgatgcacga acaccccgcc tacctgtact cgtgggaggt gtggctgact    240

gcacagaagt cactggggcc tttgacttct acacactccc tgtggggctc cgcactgtgg    300

ccgtcaccga gagccagttc ctcatcagcg ggaaaccttt ctatttccac ggcgtcaagc    360

atgaggatgc ggacatccaa gggaagggct tcgactgtcc gctgctggtg aaggacttca    420

acctgctttg ctggcttggc gccaacacct tctgcaccag ccactatccc tacacggagg    480

agatgctgca gatatgttac cggtatggga ttgtggtcat cgatgagtgt cctgctgtgg    540

gcctgatgct gccatgagtc cctgctgcgc acccgctctg cctggccagc cctcgggcca    600

cactgtgacc ctctgtccct tcccttctgg cccgctggca actcttcaac aacgtgtcta    660

tgcatcacca tatgtgggtg gtggaggaac cggtgctcag agacaa                   706


<210>  4659
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  4659

Met Ser Leu Pro Lys Pro Trp Ser Leu Leu Pro Pro Ala Gly Leu Val 
1               5                   10                  15      


Asn Tyr Gln Ile Ser Val Lys Cys Ser Asn Gln Phe Lys Leu Glu Val 
            20                  25                  30          


Cys Leu Leu Asn Ala Glu Asn Lys Val Val Asp Asn Gln Ala Gly Thr 
        35                  40                  45              


Gln Gly Gln Leu Lys Val Leu Gly Ala Asn Leu Trp Trp Pro Tyr Leu 
    50                  55                  60                  


Met His Glu His Pro Ala Tyr Leu Tyr Ser Trp Glu Val Trp Leu Thr 
65                  70                  75                  80  


Ala Gln Lys Ser Leu Gly Pro Leu Thr Ser Thr His Ser Leu Trp Gly 
                85                  90                  95      


Ser Ala Leu Trp Pro Ser Pro Arg Ala Ser Ser Ser Ser Ala Gly Asn 
            100                 105                 110         


Leu Ser Ile Ser Thr Ala Ser Ser Met Arg Met Arg Thr Ser Lys Gly 
        115                 120                 125             


Arg Ala Ser Thr Val Arg Cys Trp 
    130                 135     


<210>  4660
<211>  4924
<212>  DNA
<213>  Homosapiens

<400>  4660
ttatatggtt tggctctgtc cccacccaaa tctcatctgg aattgtaaca attcccatgt     60

gtcaagggtg gggccaggtg gagataattg aatcatggag gcagtttccc ccatgctgtt    120

ctcatggtag tgaataagtc tcatgagatc tgacggtttt atcaatggga gttcccctgc    180

acatgctctc tcctgcccac catgtctgac taaattttgt atttttacta gagacggggt    240

ttcactatgt tggccaggct ggtctccaac tcctgatctc gtgatccatc cacctcgacc    300

tcccaaagtg ctaggattat aggcataagc caccacaccc ggcctctttt ttttcttttt    360

ctttttttta tctggagact gagttttgca cttgttgccc aggctggagt gcaatggtgc    420

gatctcagct cactgcagtc tccgcctcag caggagagca ggaatcttca gtgatccacg    480

ggcagatctg cagccactgt gggcacctgc tcctcccgcg acctttgtgc ccgcgtctct    540

ccctccagta cctattgcac gacaccccac gtccgcctcc tgccattgcc agcaagtgcc    600

ttgtgcgagt acctggctgt gcttattaat ccattatggt cgctctgtca ctggtgccat    660

tatgtgctca cgtgcccact ccctcaggtt tagaaggcgc gttgcccggc aacagaagag    720

tctgctggct tagcctttgg ccgagttggc agctggatga ggacgctcag agcccagctc    780

tcgagagttc aagcatccga cggttcccca ctgctcccag gagcggttac ccgggcactc    840

tgtgcccctc attcctgttt gggccaaggc tgaggacctg cgagtagggc tcagttgcct    900

ggagcccctt caacccatcc cccagttcac tttgcttgtg ggatctcccc gttgctcctg    960

cccctggact gagtggcagg tcatcctaca agcacccaga cactcgacat cagtggtgtc   1020

aagacaactc caagaaggtt ttccgtgatc ctgcaagacc tgtgttccat cctggtgatt   1080

ctgccttcaa tttcactgca caggtaccat agcaagtcag tgctgtgtgc tccgagttcc   1140

agggcatcct ccagctcggc cactacactg agcacaagga ctctgtgggg ccccaggagc   1200

aggtagtcac cccattgggg ttcacaacac ccggctgtcc ccagacttgt gtccagggaa   1260

gatagtgttg agggccctca aggagagcgg ggcagggatg cctgagcagg acaaggaccc   1320

tagagtccaa gagaatcctg atgatcagag aagggtcccc aaggtcaccg gggatgcacg   1380

gtctgcattt cggcccctgc gggacaatgg agtcctctct ccctttgtgc ccaggcccgg   1440

gcctctgcag acatacctcc atgcccagag ctcagaaatc agatataacc agacatccca   1500

gacctcctgg gcgagctcgt gcaccaaaag aaatgccatc tccagctcct acagctccac   1560

gggagacttg ccggggctaa agcagaggag ggagccagcc tcatcccact gccagctgac   1620

cctcagttac gcaatgacag tgagtgagga caggcttcag gctgtctctt cgggtcacac   1680

acggtgtgaa aaggcggcag atacagcacc agggcagaca ctcgccccaa ggggtggctc   1740

ccccagatct caggcctcta ggccccatag acacaagatt cccctgctgc cacgcaggcg   1800

aggggagcct ttgatgctgc cacctccctt agagcggggg taccgggtca ctgctgaaga   1860

cctgcacctg gaaaaagagg cggcattaca gcggatcaac agtgcactgc aggttgagga   1920

caaggccatc tcggattgca gaccctcacg gccttcccac actttgtcct cacttgcaac   1980

aggggcttct ggtgggtctc ccgtttctaa agcacccact atggatgcac agcaggacag   2040

acccaagtcc caagactgcc tgggcctagt ggccccccta gcatctgctg cagaggtccc   2100

ctctacagct cctgtgtctg ggaagaagca cagaccacca ggacccctgt tctcctcctc   2160

agatcccctt cctgccacat gttcccactc ccgggactca gcccagtaca cctcgctgat   2220

tcctgccccc ttcacagctg aaagcatgga tgccggcatg agaagaagga ggcctggcac   2280

atcggctcct gcagctgccg cagcagcccc tcccccctcc acattgaacc ccatgttggg   2340

gttactactc aatgcaatgg atgcaggccc ctcatatttc tgggcctcag ccacagctgc   2400

agcaggtgcc cagaggtcag aagtgagata taaccagaga tcccagacct cccggaccag   2460

atcgtgcacc aaacgaaatg ccagctcgag ctcctacagc tctacggaag gcctcccgga   2520

actaaagcgg aggagggggc cagcctcatc ccactgccag ctgaccctca gttcctcaaa   2580

cacagtgagt gaggacggac ctcaggctgt ctcttcgggt aacagccact gtgaaaacaa   2640

cgcggataca gcaccagggc agacactcgc ccccaggggt ggctccccca gatcccaggc   2700

ctctaggccc cgcatcaaca gtgcactgca ggttgaggac aaggccatct cacactgcag   2760

accctcacgg ccttcccaca ctttgtcctc acttgcaaca ggggcttctg gtgggtctag   2820

cgtttctaaa gcacccacta tggatgcaca gcaggacaga cccaagtccc aagactgcct   2880

gggcctagtg gcccccctag catctgctgc acaggtcccc tctacagctc ccgtgtctgg   2940

gaagaagcac agaccaccag gacccctgtt ctcctcctca gatccccttc ctgccacctt   3000

ttcccactcc cgggactcag cccaggtcac ctcgctgatt cctgccccct tcactgctga   3060

aagcatggat gccggcatga gaagaacaag gcctggcacg tcggctgctg caggtgccgc   3120

agcagcccct ctccccttca cattgaaccc catgttgggg ttactactca atgcaatgga   3180

tgcaggcccc tcatgtttct gggcctcagc cacagctgca gcaggtgccc agaggtcaga   3240

agtgagatat aaccagagat cccagacctc ccggaccaga tcgtgcacca aacgaaatgc   3300

cagctcgagc tcctacagct ctacggaagg cctcccggaa ctaaagcgga ggagggggcc   3360

agcctcatcc cactgccagc tggccctcag ttcctcaaac acagtgagtg aggacggacc   3420

tcaggctgtc tcttcgggtc acagccactg tgaaaacaac gcagatacag caccagggca   3480

gacactcgcc cccaggggtg gctcccccag atcccaggcc tctaggcccc gcatcaacag   3540

tgcactgcaa gttgaggaca aggccatctc gcactgcaga ccctcatggc cttcccacac   3600

tttgtcctca cttgcaacag gggcttctgg tgggtctagc gtttctaaag cacccactat   3660

ggatgcacag caggacagac ccaagtccca agactgcctg ggcctagtgg cccccctagc   3720

atctgctgca caggtcccct ctacagctcc cgtgtctggg aagaagcaca gaccaccagg   3780

acccctgttc tcctcctcag atccccttcc tgccacatct tcccactccc gggactcagc   3840

ccagtatacc tcgctgattc ctgccccctt cacagctgca agcatggatg ccggcatgag   3900

aagaaggagg cctggcacgt tggctcctgc agctgccgca gcagcccctc ccccctccac   3960

attgaacccc atgttggggt tactactcaa tgcaatggat gtaggcccct catatttctg   4020

ggcctcagcc acagctgcag caggtgccca gaggtcagaa gtgagatata accagagatc   4080

ccagacctcc cggaccagat cgtgcaccaa acgaaatgcc agctcgagct cctacagctc   4140

tacggaaggc ctcccggaac taaagcggag gagggggcca gcctcatccc actgccagct   4200

ggccctcagt tcctcaaaca cagtgagtga ggacggacct caggctgtct cttcgggtca   4260

tagccactgt gaaaacaacg cagatacagc accagggcag acactcgccc ccaggagtgg   4320

ctccgccaga tcccaggcct ctaggccccg catcaacagt gcactgcagc ttgaggacaa   4380

ggccatctca cactgcagac cctcacggcc ttcccacact ttgtcctcac ttgcaacagg   4440

ggcttctggt gggtctagcg tttctaaagc acccactatg gatgcacagc aggacagacc   4500

caagtcccaa gactgcctgg gcctagtggc ccccctagca tctgctgcac aggtcccctc   4560

tacagctccc gtgtctggga agaagcacag accaccagga cccctgttct cctcctcaga   4620

tccccttcct gccacctctt cccactcccg ggactcagcc caggtcacct cgctgattcc   4680

tgcccccttc acagctgcaa gcatggatgc cggcttgaga atgaatgccg gcatgcgaag   4740

aatgttttgt gttcgaaatt gtttgagggt tggcatgatg ttagatcgac attgtaagag   4800

gagattttcc tcttctttcc aagagtcttg tgtgctcctc ttggcaggct tctgtactgc   4860

aacacagctt ctccagtgtc cagatccaga acccgtgcag tttgctccat tgtcaggctc   4920

ctga                                                                4924


<210>  4661
<211>  1208
<212>  PRT
<213>  Homosapiens

<400>  4661

Met Pro Glu Gln Asp Lys Asp Pro Arg Val Gln Glu Asn Pro Asp Asp 
1               5                   10                  15      


Gln Arg Arg Val Pro Lys Val Thr Gly Asp Ala Arg Ser Ala Phe Arg 
            20                  25                  30          


Pro Leu Arg Asp Asn Gly Val Leu Ser Pro Phe Val Pro Arg Pro Gly 
        35                  40                  45              


Pro Leu Gln Thr Tyr Leu His Ala Gln Ser Ser Glu Ile Arg Tyr Asn 
    50                  55                  60                  


Gln Thr Ser Gln Thr Ser Trp Ala Ser Ser Cys Thr Lys Arg Asn Ala 
65                  70                  75                  80  


Ile Ser Ser Ser Tyr Ser Ser Thr Gly Asp Leu Pro Gly Leu Lys Gln 
                85                  90                  95      


Arg Arg Glu Pro Ala Ser Ser His Cys Gln Leu Thr Leu Ser Tyr Ala 
            100                 105                 110         


Met Thr Val Ser Glu Asp Arg Leu Gln Ala Val Ser Ser Gly His Thr 
        115                 120                 125             


Arg Cys Glu Lys Ala Ala Asp Thr Ala Pro Gly Gln Thr Leu Ala Pro 
    130                 135                 140                 


Arg Gly Gly Ser Pro Arg Ser Gln Ala Ser Arg Pro His Arg His Lys 
145                 150                 155                 160 


Ile Pro Leu Leu Pro Arg Arg Arg Gly Glu Pro Leu Met Leu Pro Pro 
                165                 170                 175     


Pro Leu Glu Arg Gly Tyr Arg Val Thr Ala Glu Asp Leu His Leu Glu 
            180                 185                 190         


Lys Glu Ala Ala Leu Gln Arg Ile Asn Ser Ala Leu Gln Val Glu Asp 
        195                 200                 205             


Lys Ala Ile Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser 
    210                 215                 220                 


Ser Leu Ala Thr Gly Ala Ser Gly Gly Ser Pro Val Ser Lys Ala Pro 
225                 230                 235                 240 


Thr Met Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly 
                245                 250                 255     


Leu Val Ala Pro Leu Ala Ser Ala Ala Glu Val Pro Ser Thr Ala Pro 
            260                 265                 270         


Val Ser Gly Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser 
        275                 280                 285             


Asp Pro Leu Pro Ala Thr Cys Ser His Ser Arg Asp Ser Ala Gln Tyr 
    290                 295                 300                 


Thr Ser Leu Ile Pro Ala Pro Phe Thr Ala Glu Ser Met Asp Ala Gly 
305                 310                 315                 320 


Met Arg Arg Arg Arg Pro Gly Thr Ser Ala Pro Ala Ala Ala Ala Ala 
                325                 330                 335     


Ala Pro Pro Pro Ser Thr Leu Asn Pro Met Leu Gly Leu Leu Leu Asn 
            340                 345                 350         


Ala Met Asp Ala Gly Pro Ser Tyr Phe Trp Ala Ser Ala Thr Ala Ala 
        355                 360                 365             


Ala Gly Ala Gln Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Thr 
    370                 375                 380                 


Ser Arg Thr Arg Ser Cys Thr Lys Arg Asn Ala Ser Ser Ser Ser Tyr 
385                 390                 395                 400 


Ser Ser Thr Glu Gly Leu Pro Glu Leu Lys Arg Arg Arg Gly Pro Ala 
                405                 410                 415     


Ser Ser His Cys Gln Leu Thr Leu Ser Ser Ser Asn Thr Val Ser Glu 
            420                 425                 430         


Asp Gly Pro Gln Ala Val Ser Ser Gly Asn Ser His Cys Glu Asn Asn 
        435                 440                 445             


Ala Asp Thr Ala Pro Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro 
    450                 455                 460                 


Arg Ser Gln Ala Ser Arg Pro Arg Ile Asn Ser Ala Leu Gln Val Glu 
465                 470                 475                 480 


Asp Lys Ala Ile Ser His Cys Arg Pro Ser Arg Pro Ser His Thr Leu 
                485                 490                 495     


Ser Ser Leu Ala Thr Gly Ala Ser Gly Gly Ser Ser Val Ser Lys Ala 
            500                 505                 510         


Pro Thr Met Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu 
        515                 520                 525             


Gly Leu Val Ala Pro Leu Ala Ser Ala Ala Gln Val Pro Ser Thr Ala 
    530                 535                 540                 


Pro Val Ser Gly Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser 
545                 550                 555                 560 


Ser Asp Pro Leu Pro Ala Thr Phe Ser His Ser Arg Asp Ser Ala Gln 
                565                 570                 575     


Val Thr Ser Leu Ile Pro Ala Pro Phe Thr Ala Glu Ser Met Asp Ala 
            580                 585                 590         


Gly Met Arg Arg Thr Arg Pro Gly Thr Ser Ala Ala Ala Gly Ala Ala 
        595                 600                 605             


Ala Ala Pro Leu Pro Phe Thr Leu Asn Pro Met Leu Gly Leu Leu Leu 
    610                 615                 620                 


Asn Ala Met Asp Ala Gly Pro Ser Cys Phe Trp Ala Ser Ala Thr Ala 
625                 630                 635                 640 


Ala Ala Gly Ala Gln Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln 
                645                 650                 655     


Thr Ser Arg Thr Arg Ser Cys Thr Lys Arg Asn Ala Ser Ser Ser Ser 
            660                 665                 670         


Tyr Ser Ser Thr Glu Gly Leu Pro Glu Leu Lys Arg Arg Arg Gly Pro 
        675                 680                 685             


Ala Ser Ser His Cys Gln Leu Ala Leu Ser Ser Ser Asn Thr Val Ser 
    690                 695                 700                 


Glu Asp Gly Pro Gln Ala Val Ser Ser Gly His Ser His Cys Glu Asn 
705                 710                 715                 720 


Asn Ala Asp Thr Ala Pro Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser 
                725                 730                 735     


Pro Arg Ser Gln Ala Ser Arg Pro Arg Ile Asn Ser Ala Leu Gln Val 
            740                 745                 750         


Glu Asp Lys Ala Ile Ser His Cys Arg Pro Ser Trp Pro Ser His Thr 
        755                 760                 765             


Leu Ser Ser Leu Ala Thr Gly Ala Ser Gly Gly Ser Ser Val Ser Lys 
    770                 775                 780                 


Ala Pro Thr Met Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys 
785                 790                 795                 800 


Leu Gly Leu Val Ala Pro Leu Ala Ser Ala Ala Gln Val Pro Ser Thr 
                805                 810                 815     


Ala Pro Val Ser Gly Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser 
            820                 825                 830         


Ser Ser Asp Pro Leu Pro Ala Thr Ser Ser His Ser Arg Asp Ser Ala 
        835                 840                 845             


Gln Tyr Thr Ser Leu Ile Pro Ala Pro Phe Thr Ala Ala Ser Met Asp 
    850                 855                 860                 


Ala Gly Met Arg Arg Arg Arg Pro Gly Thr Leu Ala Pro Ala Ala Ala 
865                 870                 875                 880 


Ala Ala Ala Pro Pro Pro Ser Thr Leu Asn Pro Met Leu Gly Leu Leu 
                885                 890                 895     


Leu Asn Ala Met Asp Val Gly Pro Ser Tyr Phe Trp Ala Ser Ala Thr 
            900                 905                 910         


Ala Ala Ala Gly Ala Gln Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser 
        915                 920                 925             


Gln Thr Ser Arg Thr Arg Ser Cys Thr Lys Arg Asn Ala Ser Ser Ser 
    930                 935                 940                 


Ser Tyr Ser Ser Thr Glu Gly Leu Pro Glu Leu Lys Arg Arg Arg Gly 
945                 950                 955                 960 


Pro Ala Ser Ser His Cys Gln Leu Ala Leu Ser Ser Ser Asn Thr Val 
                965                 970                 975     


Ser Glu Asp Gly Pro Gln Ala Val Ser Ser Gly His Ser His Cys Glu 
            980                 985                 990         


Asn Asn Ala Asp Thr Ala Pro Gly  Gln Thr Leu Ala Pro  Arg Ser Gly 
        995                 1000                 1005             


Ser Ala  Arg Ser Gln Ala Ser  Arg Pro Arg Ile Asn  Ser Ala Leu 
    1010                 1015                 1020             


Gln Leu  Glu Asp Lys Ala Ile  Ser His Cys Arg Pro  Ser Arg Pro 
    1025                 1030                 1035             


Ser His  Thr Leu Ser Ser Leu  Ala Thr Gly Ala Ser  Gly Gly Ser 
    1040                 1045                 1050             


Ser Val  Ser Lys Ala Pro Thr  Met Asp Ala Gln Gln  Asp Arg Pro 
    1055                 1060                 1065             


Lys Ser  Gln Asp Cys Leu Gly  Leu Val Ala Pro Leu  Ala Ser Ala 
    1070                 1075                 1080             


Ala Gln  Val Pro Ser Thr Ala  Pro Val Ser Gly Lys  Lys His Arg 
    1085                 1090                 1095             


Pro Pro  Gly Pro Leu Phe Ser  Ser Ser Asp Pro Leu  Pro Ala Thr 
    1100                 1105                 1110             


Ser Ser  His Ser Arg Asp Ser  Ala Gln Val Thr Ser  Leu Ile Pro 
    1115                 1120                 1125             


Ala Pro  Phe Thr Ala Ala Ser  Met Asp Ala Gly Leu  Arg Met Asn 
    1130                 1135                 1140             


Ala Gly  Met Arg Arg Met Phe  Cys Val Arg Asn Cys  Leu Arg Val 
    1145                 1150                 1155             


Gly Met  Met Leu Asp Arg His  Cys Lys Arg Arg Phe  Ser Ser Ser 
    1160                 1165                 1170             


Phe Gln  Glu Ser Cys Val Leu  Leu Leu Ala Gly Phe  Cys Thr Ala 
    1175                 1180                 1185             


Thr Gln  Leu Leu Gln Cys Pro  Asp Pro Glu Pro Val  Gln Phe Ala 
    1190                 1195                 1200             


Pro Leu  Ser Gly Ser 
    1205             


<210>  4662
<211>  1599
<212>  DNA
<213>  Homosapiens

<400>  4662
caaggatgcg tattaagaaa ataactagaa gtggccgcat gatgtacctc tcaccaatga     60

gatgcctgtc aagggtatac gtgggtcttt tgaatctact ggtaattgct ttatgaatct    120

gggagctcca gacctaggat cttattcact gatttgaaga gttcatgcat cgagccagta    180

ggctgtgcac atgggtaaaa actggctgcg gctaaacagg tattgtaaat gaagtggact    240

tcgtggtttc tttatccacc aataaattaa aagaaaactt acaggaaatg gacacagccc    300

tggataaatg caactactaa gattcaacca agaagtaaaa atcctgaaca caccaataca    360

actaatggat ttaatcagta ataaaaagtc tctcaccaag aaacagccca ggactaaata    420

gtttcactgc tgaattctac ttaactctta aagaagaatt aatattacct cttctaaaac    480

tattccaaaa cactgaagca gagagaattc tttctaactc attctgtgag gtcaacataa    540

ccatgattcc aaaactagat aaaaacacca ccaaaaaagg aaaactacag gccaacatcc    600

ctaataaaca tacaggcaaa aattctcaac aaaatattac caaactgaat ccaacagcat    660

atcaaaaaga taatacatca tgattaagtg ggatttatcc cagggttgta aggatgtttc    720

aacatatgca aataagtaaa tgtgatacat cacatcaacc agatgaagga caaaaagtat    780

atgatcattt caacaggtgt ggaaaaacaa ttgatacaat ttaacaatga tatatgataa    840

aagctctaaa taaattgggt ttagaaggaa agtagctcag ggctatgaat gtcacatatg    900

acaaacccac agctaaccta gcaaacgggg gaaagctgaa agcttttcct atgagaactg    960

gaagaagata agaatcccca ctgtcaccac ttctattcaa catagtactg gcagtcctac   1020

ccagagaaag aaataaaggg aatccgtgct agaaagaaag aagtcaattt atctctgttt   1080

gcagatgata taaacttgtg tatacaaaaa cctaaagact ctatcaaaaa ctcttagacc   1140

tgacaagaaa ttcagcaaag tttaaggata caaaatcaac atatgataat tggtactatt   1200

tctatacatg aacaacaagc tagctgaaaa agaattattt tttctgaatc tggttcctgc   1260

tgttgcattt cttgttaaag tattattcat gctctcttat tctacttaga tgatcattgt   1320

ttacatttat tcaatttatc atttcctttc tgttatttag cactgcttat ttaaaattat   1380

aaatttgagt caactatttc acaagataat attcaactat atttattaca gtgcagaaca   1440

tggaaaggtt cagaatttta aaaggcatat gtcttaaagg agcaaaattt aattatactc   1500

tgaatattaa gtacatttga gagatgtatc ttcaagttta aagttctttt tctggattct   1560

acatctggaa gaaataaaat gcagagtttt aaaaaattt                          1599


<210>  4663
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  4663

Met Arg Ile Lys Lys Ile Thr Arg Ser Gly Arg Met Met Tyr Leu Ser 
1               5                   10                  15      


Pro Met Arg Cys Leu Ser Arg Val Tyr Val Gly Leu Leu Asn Leu Leu 
            20                  25                  30          


Val Ile Ala Leu 
        35      


<210>  4664
<211>  1854
<212>  DNA
<213>  Homosapiens

<400>  4664
ataaaacact gatttgaata tatgctttta taaagtaagg aaaactgagt cccaggtcct     60

tttcttgacc taactagctg tatgatcttg agagaatcat ttcatccatc tggagtttga    120

actctacatc tgtaaaataa tgtaattata attgacttca gaaattcttg gagctttaat    180

atcctaattt tattatattt tatctgaggg tctgcagcat tagggtaaaa gataacatcc    240

gtacagtggt ccaggtcaat accttgctta gtagatgttc aataaatcct agttaaaggt    300

acatttttag ggaaaatgca gaatggagag gcgtgttagg gttattgaac tagttctctc    360

ccagctgctc tgtccaagtc atcattatct gtggtctcta ccagtgcagc aagctcctgt    420

tttccccact catggcactg acagagcagt gcctcacagc ctcagagctc tgtcacagcc    480

ctccagtgac ttcctgtctc acccagacaa aagtccacag tctctaacct ggccagcaag    540

gtcctccatg gttgaactcc tttccctgat tccctcggcc tctgacttct gctaccaccg    600

tctgcctgat tctggctact cagctgccag ccctcctccc tctcctatcc agtacactcc    660

tacatcggga cctggggact ttattgtccc tctacctggg cttcccattg ccccaggcat    720

tcacgtgcct tgctctcact ttctttaggt ctgtgttcaa acaatgtctt tatccaagag    780

gcagcgactc tgacctctct atataaaaat aacaccttgt tctctgcatt ctctatactt    840

ttactgtgct ttatttttcc tcaggcactt atcatccctg acattatata tttatggtag    900

gttgttcaca gctgttcctg ctttctgccc tgtattacat tgcttggcac atgcagatgt    960

ttaataagta aggataacta gaatttatat agcatgtact gtgttccagg cgccatctga   1020

aaacagcact acgaagaact attctttttc cctatttaca ggtgaagaaa ctgaggccca   1080

gaaaagttag gtaacttgaa aaaggttcac acagatgaga actagctgat ctgggaggaa   1140

gttaagtgag taagcaacta aaagaagagg gccgggcgca gtggctcatg cctgtaatcc   1200

cagcactttg ggaggccaag gcaagtggat cacctgaggc tgtgagttca agaccagcct   1260

gaccaacatg gagaaacccc atctctacta aaaatgcaaa attagacggg cgtggtagct   1320

catgcctgta accccagcta ctcaggaagc tgaggcagga gaattgcttg aacctgggag   1380

gcggaggttg cagtgagctg ggatcgctcc attgcactcc agcctgggca acaagagcga   1440

aactctgtct aaaaaaaaaa aaagaaagaa agaaatgagg agataaagtc ctggggtcta   1500

ttatacttga aaaaatacac tttatatttt ttaaaaacag attagaaaca aatagcactc   1560

actctgacat catctactgt ttagagaatt ctactttata aacacttcct aggaaccccg   1620

aatcagatgg tagaaagata aattttaaac atatttctgc attttttcct ctccaaagga   1680

tacttttcca tctccagaag atatttcaac tgtatcttcc caaagcgttg acctttttaa   1740

ctcagataac ttcagaaacc agaaaagttg cattttctaa gaaattctcc ttaaatgtcc   1800

tgaatattca ccatccagac tgaattacga ttgcacactt gattcaggaa ttag         1854


<210>  4665
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  4665

Met Glu Arg Arg Val Arg Val Ile Glu Leu Val Leu Ser Gln Leu Leu 
1               5                   10                  15      


Cys Pro Ser His His Tyr Leu Trp Ser Leu Pro Val Gln Gln Ala Pro 
            20                  25                  30          


Val Phe Pro Thr His Gly Thr Asp Arg Ala Val Pro His Ser Leu Arg 
        35                  40                  45              


Ala Leu Ser Gln Pro Ser Ser Asp Phe Leu Ser His Pro Asp Lys Ser 
    50                  55                  60                  


Pro Gln Ser Leu Thr Trp Pro Ala Arg Ser Ser Met Val Glu Leu Leu 
65                  70                  75                  80  


Ser Leu Ile Pro Ser Ala Ser Asp Phe Cys Tyr His Arg Leu Pro Asp 
                85                  90                  95      


Ser Gly Tyr Ser Ala Ala Ser Pro Pro Pro Ser Pro Ile Gln Tyr Thr 
            100                 105                 110         


Pro Thr Ser Gly Pro Gly Asp Phe Ile Val Pro Leu Pro Gly Leu Pro 
        115                 120                 125             


Ile Ala Pro Gly Ile His Val Pro Cys Ser His Phe Leu 
    130                 135                 140     


<210>  4666
<211>  1854
<212>  DNA
<213>  Homosapiens

<400>  4666
ataaaacact gatttgaata tatgctttta taaagtaagg aaaactgagt cccaggtcct     60

tttcttgacc taactagctg tatgatcttg agagaatcat ttcatccatc tggagtttga    120

actctacatc tgtaaaataa tgtaattata attgacttca gaaattcttg gagctttaat    180

atcctaattt tattatattt tatctgaggg tctgcagcat tagggtaaaa gataacatcc    240

gtacagtggt ccaggtcaat accttgctta gtagatgttc aataaatcct agttaaaggt    300

acatttttag ggaaaatgca gaatggagag gcgtgttagg gttattgaac tagttctctc    360

ccagctgctc tgtccaagtc atcattatct gtggtctcta ccagtgcagc aagctcctgt    420

tttccccact catggcactg acagagcagt gcctcacagc ctcagagctc tgtcacagcc    480

ctccagtgac ttcctgtctc acccagacaa aagtccacag tctctaacct ggccagcaag    540

gtcctccatg gttgaactcc tttccctgat tccctcggcc tctgacttct gctaccaccg    600

tctgcctgat tctggctact cagctgccag ccctcctccc tctcctatcc agtacactcc    660

tacatcggga cctggggact ttattgtccc tctacctggg cttcccattg ccccaggcat    720

tcacgtgcct tgctctcact ttctttaggt ctgtgttcaa acaatgtctt tatccaagag    780

gcagcgactc tgacctctct atataaaaat aacaccttgt tctctgcatt ctctatactt    840

ttactgtgct ttatttttcc tcaggcactt atcatccctg acattatata tttatggtag    900

gttgttcaca gctgttcctg ctttctgccc tgtattacat tgcttggcac atgcagatgt    960

ttaataagta aggataacta gaatttatat agcatgtact gtgttccagg cgccatctga   1020

aaacagcact acgaagaact attctttttc cctatttaca ggtgaagaaa ctgaggccca   1080

gaaaagttag gtaacttgaa aaaggttcac acagatgaga actagctgat ctgggaggaa   1140

gttaagtgag taagcaacta aaagaagagg gccgggcgca gtggctcatg cctgtaatcc   1200

cagcactttg ggaggccaag gcaagtggat cacctgaggc tgtgagttca agaccagcct   1260

gaccaacatg gagaaacccc atctctacta aaaatgcaaa attagacggg cgtggtagct   1320

catgcctgta accccagcta ctcaggaagc tgaggcagga gaattgcttg aacctgggag   1380

gcggaggttg cagtgagctg ggatcgctcc attgcactcc agcctgggca acaagagcga   1440

aactctgtct aaaaaaaaaa aaagaaagaa agaaatgagg agataaagtc ctggggtcta   1500

ttatacttga aaaaatacac tttatatttt ttaaaaacag attagaaaca aatagcactc   1560

attctgacat catctactgt ttagagaatt ctactttata aacacttcct aggaaccccg   1620

aatcagatgg tagaaagata aattttaaac atatttctgc attttttcct ctccaaagga   1680

tacttttcca tctccagaag atatttcaac tgtatcttcc caaagcgttg acctttttaa   1740

ctcagataac ttcagaaacc agaaaagttg cattttctaa gaaattctcc ttaaatgtcc   1800

tgaatattca ccatccagac tgaattacga ttgcacactt gattcaggaa ttag         1854


<210>  4667
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  4667

Met Glu Arg Arg Val Arg Val Ile Glu Leu Val Leu Ser Gln Leu Leu 
1               5                   10                  15      


Cys Pro Ser His His Tyr Leu Trp Ser Leu Pro Val Gln Gln Ala Pro 
            20                  25                  30          


Val Phe Pro Thr His Gly Thr Asp Arg Ala Val Pro His Ser Leu Arg 
        35                  40                  45              


Ala Leu Ser Gln Pro Ser Ser Asp Phe Leu Ser His Pro Asp Lys Ser 
    50                  55                  60                  


Pro Gln Ser Leu Thr Trp Pro Ala Arg Ser Ser Met Val Glu Leu Leu 
65                  70                  75                  80  


Ser Leu Ile Pro Ser Ala Ser Asp Phe Cys Tyr His Arg Leu Pro Asp 
                85                  90                  95      


Ser Gly Tyr Ser Ala Ala Ser Pro Pro Pro Ser Pro Ile Gln Tyr Thr 
            100                 105                 110         


Pro Thr Ser Gly Pro Gly Asp Phe Ile Val Pro Leu Pro Gly Leu Pro 
        115                 120                 125             


Ile Ala Pro Gly Ile His Val Pro Cys Ser His Phe Leu 
    130                 135                 140     


<210>  4668
<211>  309
<212>  DNA
<213>  Homosapiens

<400>  4668
atggctggaa taacatgcat agaattcaga atccggatgg caaagaagat catagacatt     60

caggagaaag ttgaaaccca cttcaagaaa tctaacaaat taactaaagt gatacaagag    120

ctgaaagatg aaatagacat attaagaaag agccaaactg atctgatcaa gctgaaaaac    180

tcactacaag aatttcataa cacaattgga agtattaaca gtgtaataaa ccaaatggag    240

aaaagaacct cagagcttga agactggata tctgaactaa gtcagagaaa aatcaagaaa    300

aaagaatga                                                            309


<210>  4669
<211>  102
<212>  PRT
<213>  Homosapiens

<400>  4669

Met Ala Gly Ile Thr Cys Ile Glu Phe Arg Ile Arg Met Ala Lys Lys 
1               5                   10                  15      


Ile Ile Asp Ile Gln Glu Lys Val Glu Thr His Phe Lys Lys Ser Asn 
            20                  25                  30          


Lys Leu Thr Lys Val Ile Gln Glu Leu Lys Asp Glu Ile Asp Ile Leu 
        35                  40                  45              


Arg Lys Ser Gln Thr Asp Leu Ile Lys Leu Lys Asn Ser Leu Gln Glu 
    50                  55                  60                  


Phe His Asn Thr Ile Gly Ser Ile Asn Ser Val Ile Asn Gln Met Glu 
65                  70                  75                  80  


Lys Arg Thr Ser Glu Leu Glu Asp Trp Ile Ser Glu Leu Ser Gln Arg 
                85                  90                  95      


Lys Ile Lys Lys Lys Glu 
            100         


<210>  4670
<211>  1023
<212>  DNA
<213>  Homosapiens

<400>  4670
tagggcaact ggaaggctgg gagctgaaat cacctgaagt ctcattcact cacatgtctg     60

atggttgata ttgtctatca gattcttttt tgtctccttc tctgcaagag gctggcacca    120

gatcacctcc tgagtagagc agacattcca aaggatgtcc tgccaacaat aatggaaagc    180

tggatacaac tgaatatgta aaatgatgtt aatgaagaat tgaagagcac tgtatctagt    240

tttctgctct ccccttattt tgaatcaaac ccaggcatcc tatcatttca tctataaaga    300

ctttagttcc taaaagtgga attgctggat caaagggtaa aggcataggc aattctagag    360

catttagatt taatgtgatg gacaggaatg aaccatgaag ccacgagtgt ttgattttta    420

aattgtgata ttccactaaa tgagaaatga ccaggacttc acagagattt catgaaagga    480

gggccacaaa ggaagaaccc agagcaggcc ggtgagaggc actctaagag ctttccaata    540

tccgtcttcg gagcgcacgg gaatccgccg agctctgcgt gcaggccctt ttttcttttg    600

aggttcacat tttttgaaat tttacgccag ggcttttgta atttcctccc ccgcccgctg    660

acggtcctgg agtcgctcgg ggctttaggc cggttatgca acgtgtaccg ctcggggctg    720

ccggctgcac ctccgccgcg cctcgccgct cactgcgcta gacccggcgc cccgcgtctc    780

gcttcgcggg cagtcagggg gccggcgctc tgtcgaggtc tccagctaga gcagggagcc    840

cgagcccgag ggagtccccg gagccgacga agggcttatt agaccctgac tcttttctga    900

ggcgcgcaga ttttgtcttt gatcactccc tctccgcggg tctacggccg cgcgctttcg    960

gcgccggcga tggggagaag acggaggctg tgtctccagc tctacttcct gtggctgggc   1020

tgt                                                                 1023


<210>  4671
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  4671

Met Lys Gly Gly Pro Gln Arg Lys Asn Pro Glu Gln Ala Gly Glu Arg 
1               5                   10                  15      


His Ser Lys Ser Phe Pro Ile Ser Val Phe Gly Ala His Gly Asn Pro 
            20                  25                  30          


Pro Ser Ser Ala Cys Arg Pro Phe Phe Leu Leu Arg Phe Thr Phe Phe 
        35                  40                  45              


Glu Ile Leu Arg Gln Gly Phe Cys Asn Phe Leu Pro Arg Pro Leu Thr 
    50                  55                  60                  


Val Leu Glu Ser Leu Gly Ala Leu Gly Arg Leu Cys Asn Val Tyr Arg 
65                  70                  75                  80  


Ser Gly Leu Pro Ala Ala Pro Pro Pro Arg Leu Ala Ala His Cys Ala 
                85                  90                  95      


Arg Pro Gly Ala Pro Arg Leu Ala Ser Arg Ala Val Arg Gly Pro Ala 
            100                 105                 110         


Leu Cys Arg Gly Leu Gln Leu Glu Gln Gly Ala Arg Ala Arg Gly Ser 
        115                 120                 125             


Pro Arg Ser Arg Arg Arg Ala Tyr 
    130                 135     


<210>  4672
<211>  1023
<212>  DNA
<213>  Homosapiens

<400>  4672
tagggcaact ggaaggctgg gagctgaaat cacctgaagt ctcattcact cacatgtctg     60

atggttgata ttgtctatca gattcttttt tgtctccttc tctgcaagag gctggcacca    120

gatcacctcc tgagtagagc agacattcca aaggatgtcc tgccaacaat aatggaaagc    180

tggatacaac tgaatatgta aaatgatgtt aatgaagaat tgaagagcac tgtatctagt    240

tttctgctct ccccttattt tgaatcaaac ccaggcatcc tatcatttca tctataaaga    300

ctttagttcc taaaagtgga attgctggat caaagggtaa aggcataggc aattctagag    360

catttagatt taatgtgatg gacaggaatg aaccatgaag ccacgagtgt ttgattttta    420

aattgtgata ttccactaaa tgagaaatga ccaggacttc acagagattt catgaaagga    480

gggccacaaa ggaagaaccc agagcaggcc ggtgagaggc actctaagag ctttccaata    540

tccgtcttcg gagcgcacgg gaatccgccg agctctgcgt gcaggccctt ttttcttttg    600

aggttcacat tttttgaaat tttacgccag ggcttttgta atttcctccc ccgcccgctg    660

gcggtcctgg agtcgctcgg ggctttaggc cggttatgca acgtgtaccg ctcggggctg    720

ccggctgcac ctccgccgcg cctcgccgct cactgcgcta gacccggcgc cccgcgtctc    780

gcttcgcggg cagtcagggg gccggcgctc tgtcgaggtc tccagctaga gcagggagcc    840

cgagcccgag ggagtccccg gagccgacga agggcttatt agaccctgac tcttttctga    900

ggcgcgcaga ttttgtcttt gatcactccc tctccgcggg tctacggccg cgcgctttcg    960

gcgccggcga tggggagaag acggaggctg tgtctccagc tctacttcct gtggctgggc   1020

tgt                                                                 1023


<210>  4673
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  4673

Met Lys Gly Gly Pro Gln Arg Lys Asn Pro Glu Gln Ala Gly Glu Arg 
1               5                   10                  15      


His Ser Lys Ser Phe Pro Ile Ser Val Phe Gly Ala His Gly Asn Pro 
            20                  25                  30          


Pro Ser Ser Ala Cys Arg Pro Phe Phe Leu Leu Arg Phe Thr Phe Phe 
        35                  40                  45              


Glu Ile Leu Arg Gln Gly Phe Cys Asn Phe Leu Pro Arg Pro Leu Ala 
    50                  55                  60                  


Val Leu Glu Ser Leu Gly Ala Leu Gly Arg Leu Cys Asn Val Tyr Arg 
65                  70                  75                  80  


Ser Gly Leu Pro Ala Ala Pro Pro Pro Arg Leu Ala Ala His Cys Ala 
                85                  90                  95      


Arg Pro Gly Ala Pro Arg Leu Ala Ser Arg Ala Val Arg Gly Pro Ala 
            100                 105                 110         


Leu Cys Arg Gly Leu Gln Leu Glu Gln Gly Ala Arg Ala Arg Gly Ser 
        115                 120                 125             


Pro Arg Ser Arg Arg Arg Ala Tyr 
    130                 135     


<210>  4674
<211>  198
<212>  DNA
<213>  Homosapiens

<400>  4674
atgtatgcca tcgacctcat gctgaagtgg gacaaccgtc cagatggaaa gcgggtgatg     60

cagctgcaga tcctggaggt gaacttcaac cctgactgca agcgagcctg caggtaccat    120

ctctccttct tcaacaacgt cttcagcacc ttgtttctgg accagcccag tgactgtcat    180

gtcgcctgcc ttgtctag                                                  198


<210>  4675
<211>  65
<212>  PRT
<213>  Homosapiens

<400>  4675

Met Tyr Ala Ile Asp Leu Met Leu Lys Trp Asp Asn Arg Pro Asp Gly 
1               5                   10                  15      


Lys Arg Val Met Gln Leu Gln Ile Leu Glu Val Asn Phe Asn Pro Asp 
            20                  25                  30          


Cys Lys Arg Ala Cys Arg Tyr His Leu Ser Phe Phe Asn Asn Val Phe 
        35                  40                  45              


Ser Thr Leu Phe Leu Asp Gln Pro Ser Asp Cys His Val Ala Cys Leu 
    50                  55                  60                  


Val 
65  


<210>  4676
<211>  198
<212>  DNA
<213>  Homosapiens

<400>  4676
atgtatgcca tcgacctcat gctgaagtgg gacaaccgtc cagatggaaa gcgggtgatg     60

cagctgcaga tcctggaggt gaacttcaac cctgactgca agcgagcctg caggtaccat    120

ctctccttct tcaacaacgt cttcagcacc ttgtttctgg accagcccag tgactgtcat    180

gtcgcctgcc ttgtctag                                                  198


<210>  4677
<211>  65
<212>  PRT
<213>  Homosapiens

<400>  4677

Met Tyr Ala Ile Asp Leu Met Leu Lys Trp Asp Asn Arg Pro Asp Gly 
1               5                   10                  15      


Lys Arg Val Met Gln Leu Gln Ile Leu Glu Val Asn Phe Asn Pro Asp 
            20                  25                  30          


Cys Lys Arg Ala Cys Arg Tyr His Leu Ser Phe Phe Asn Asn Val Phe 
        35                  40                  45              


Ser Thr Leu Phe Leu Asp Gln Pro Ser Asp Cys His Val Ala Cys Leu 
    50                  55                  60                  


Val 
65  


<210>  4678
<211>  5572
<212>  DNA
<213>  Homosapiens

<400>  4678
ctcggaaaag cttttcagta aatgcactca tgctgctcca ggagctcttc tctgcaacaa     60

gccacccatc tgccatcaac aagttaagac caagagaact aacggctgcg gaaatgagac    120

tgaagctttg attaaccagc tgagcagtta gaggtggaga aatttaataa cttatattca    180

aaactgattt agggatcaga gcaatcacag aaaatgaaac caatgctttc cagagggata    240

tcctaaggaa aaaacaactc gtcctggtgg attcaatttt acttggaaag cctgggacac    300

agaaaacagg aaactggtca aaggctccta catgttagag ccttttacag actcactgcg    360

ttgagtctaa caaccgcgac tgaatgcagc ctccaatgtg ctcagaagaa tgggcttaca    420

tttcaagtgg ccattagggg cccctatgct ggcagcaata tatgcaatga gtatggtttt    480

aaaaatgctg cctgccctgg gtatggcgtg tccacccaaa tgccgctgcg agaagctgct    540

cttctactgc gactctcagg gcttccactc agtgccaaac gccacagaca agggctctct    600

gggcctgtcc ctgaggcaca atcacatcac agagctcgaa agagatcaat ttgccagctt    660

cagtcaactt acttggctcc acttagatca caatcaaatt tcaacagtaa aagaagatgc    720

ttttcaagga ctatataaac ttaaggaatt aatcttaagt tccaacaaaa tattttactt    780

gccaaacaca acttttaccc aactgattaa cctgcaaaat ttggacctgt cttttaatca    840

gctgtcatct ctgcacccag agctcttcta tggccttcgg aagctgcaga ccttgcattt    900

acgttccaac tccctgcgga ctatcccagt acgcctgttc tgggactgtc gtagtctgga    960

gtttctggat ttgagcacaa atcgtttgcg aagtttggct cgcaatggat ttgcaggatt   1020

aattaaactg agagagcttc acctagagca caaccagctg acgaagatta attttgctca   1080

tttcctacgg ctaagcagtc tgcacacgct cttcttacaa tggaacaaaa tcagcaactt   1140

gacatgtggg atggagtgga cctggggcac tttagaaaag ctagacctga ctggaaatga   1200

aatcaaagcc atcgacttga cagtgtttga aacgatgccc aatcttaaaa tactactcat   1260

ggataacaac aagttaaaca gccttgattc caagatctta aactccctga gatccctcac   1320

aaccgttggt ctctctggca atctgtggga atgcagcgcc cgaatatgtg ctctggcctc   1380

ctggctgggc agtttccaag gtcggtggga acactccatc ctatgccaca gtcctgacca   1440

cacccaagga gaggatattc tagatgcagt ccatggattt cagctctgct ggaatttgtc   1500

aaccactgtc actgtcatgg ctacaactta tagagatcca accactgaat atacaaaaag   1560

aataagctca tcaagttacc atgtgggaga caaagaaatc ccaactactg caggcatagc   1620

agttactacc gaggaacact ttcctgaacc agacaatgcc atcttcactc agcgggtaat   1680

tacgggaaca atggctttat tgttttcttt cttttttatt atttttatag tgttcatctc   1740

caggaagtgc tgccctccca ctttaagaag aattaggcag tgctcaatgg ttcagaacca   1800

caggcagctc cgatcccaaa cacgactcca tatgtcaaac atgtcagacc aaggaccgta   1860

taatgaatat gaacccaccc atgaaggacc cttcatcatc attaatggtt atggacagtg   1920

caagtgtcag cagctgccat acaaagaatg tgaagtataa tatctaccca tcatcaaaaa   1980

tcacatcaga taagtaacct attttacata gtagaggcta aatacatatc taatttttac   2040

caatggtgac attaagccta attttccaaa ctaagtggag acttagtttt tgaagtgttg   2100

aagtattttt aattttttta aatgaaacca tattttaagt gttaaatgaa tcaatgctca   2160

cattaatttg cactcctgtt ggaaagtcta aaatgcttac ttcaaaataa gaaatgtacg   2220

taattatata caatcgtgtg taaaccttta cactaaggtc tccatatact atttttttct   2280

actgaaaaca atttagaaag aagctattgg gcagaaacag atatagatca atacctgttt   2340

gatcactgct ctccatccca tgtaccacaa ctatcttgct gcttaaaagg agacttagta   2400

aagttctctt gtatgataat ttggtattta ctcaaatctt caatttcttg ccagggtggg   2460

aagtagaatt tcatgtatgc tgaagactgg taaatattaa acattctcct tccagagttt   2520

ctgcctgggt tagtagatat tatcaaagtc catatcatga attcagaacc ctttaatgta   2580

attctaataa gctgagtgac tctttaatat atttacacaa tgaatccaag tgactgtgaa   2640

aaggtctcat tacaatgaaa ccaatcctaa ataattacac caacttctta tacatttctc   2700

gtttgactta taatggacat gatttttgtg gcatttagac aactgtttta aactagcatt   2760

aaactgtcat tgtactaatt aatgtactaa atcctatgtt tacattaata tgtgaaaaaa   2820

gatttagaag atattttgga gataaacaag acaaactgag tcaatttaac aatcctgaca   2880

tgctccctcc aatttaaaag cacacacaca cacacacaca cacacacaca cactctcgcg   2940

ctctctctct caactatcat gatcaaagat gccttgacaa aggggtttaa acctctttct   3000

tctgcttttt cctgatcttc aaacctcaaa gagccaagtt aaaaataatt ggctagcaac   3060

aggcttaaca ctgattctta ttgtattaca aaggaaccat gaaaaaaaac actttctaac   3120

tattatataa tacatttcga tctttcaata aagatacgca ttcacgctgt aagtgtagtt   3180

cagtgtaggt gaagaaaaca gcaccactga gatgaatctc atggcagaac aactcgacat   3240

gcctatgcag ccacacagtg gtaacttgaa ggcagcacag aggtgaggga ttaaaaggaa   3300

aggcagattt tgaaatctga ctctcaggtt agctggagtt acaaggcagc caacaatgat   3360

tatacacaat ctgcaccaaa cagggaaagg acctgctgct gaaaagggaa gaggggtaga   3420

tcctccaatg taaatataaa catgccatag ttaacaaatg ataaggatgc cacatttttc   3480

atgcagaaaa gaaccacagg tattcagttt cttgtattat gatttctaaa gaaaacctat   3540

taaatatttg gaatttagat gcaagctact cattcacaca gaacttttcc ataaacattg   3600

ttccacatat tgaaaaaact gtaaaattat agcactaact tgattttaga aaatgagcat   3660

tttttacaac tgccatttac tgtatgtaga aaaaagacat aaaaccttag agaaagccac   3720

taccattttt caagttatct tttccccaac atcaacatca acatgatatc cttcattcag   3780

ggcatatttt ttcttcccag gatcaaactg aaaacatgtt aaggctatag tttagccagt   3840

aagatttaat cacaattttt cttctttaat actaagagat gggtacctta gtacccttca   3900

cctaacatct ctcggtaaaa agcagacaag atcacaaatt acagtaaaaa tgtgctcttt   3960

tttaaggtgg gcagattagt ttgtcaaagt ctcagcccag ttcaattcag ttgatctcga   4020

gtggtgagta ttttgtctct tgttaaacca gaccctgggc ttgtctgggc agagacagaa   4080

gctgatttaa cagcatagag cacagcgccc tacttcccca cagacaggct gaattagaag   4140

cccctattac aaataagagc accacgagct aaaatttacc aacccattta tcaggatgac   4200

cattgccatt tgtcaggtga cagacagctt ggtcacaaca caactgtgtc ctgagcacac   4260

aagattccat cagccctgaa ggacagcaga ggagtatttt ccatcatttc aaaccacaaa   4320

caaaattaag atttaaactg tgggatgggt aagaaatccc cttctttggc tgggaatctc   4380

caccttaatc cttaaaggac cataactggc aaaatcctta gtgtacggac aaaagcaaat   4440

tggaaaagca agccatttac taattcagag gaacagcata gccaaggcta gcgaggcata   4500

ctttccagtt gaaaaaaaat caaaattttt tgccttccat ttttctgggt aatgtccttt   4560

aagaaaagtg aatgacagta gtaccaaaaa ggtattttcc tttctcattt aaaagcaaaa   4620

acctcccttt ttaattgcct gtagaaggca agattttctt tcatttttgt ccatttgtgt   4680

ttcagaatca gcacaggttt gaagattaga ctgttagtca tctgtgcttt ctttaccaac   4740

tggctagaac ggaacagcat cacagcaacg ctgcggatct tggttacaca gtgtcagagc   4800

ttttgttttt tgatggggtt ttatcctctt caccaccact acccactcca ttttttttct   4860

atttttaaga ttagaggaaa atgaccatta agaaccagaa aaataattaa tctctctgga   4920

aaaaggaaag ctaaagaaga ctatgatacc atacccatct agaaaccaag aactagtttg   4980

aaatcgttta tattcatttc tgtagcatga cagggatttc aatcaccttt ctgaaaagag   5040

tgggctgata aacttgtaaa tccacacaca actctgagaa tacccactgc cagcatcaaa   5100

aagcaaagat actaattttt taagccaaaa atctgtacta acacatgtaa tttcttaatg   5160

tgcctaagtt aatttctgta tcaattcaat aaatggaatt gactgaactt cccaacgcca   5220

ctaattatta aaatccatct gcttattcta atgctagtca ccaagagcta gactccatct   5280

ttccaataaa aatgagccct atgtagcact aggtttgaat tctaaaattc aaaacaggca   5340

tttcattttc ttaaggcaca cttcctacac acagctatca ggggaaaaag ctataaatgt   5400

cctgttcttt ttctgaagtg tggatatcaa tataaaattt gttaaagaat atttttaaca   5460

gctgacttac atgatcgttt tcctaataca ggaatacagc gacagaccta tctgaaaagt   5520

ctgtttgggg gcatactttt catatcttat tgactaaagc ccttgagcca gg           5572


<210>  4679
<211>  516
<212>  PRT
<213>  Homosapiens

<400>  4679

Met Gly Leu His Phe Lys Trp Pro Leu Gly Ala Pro Met Leu Ala Ala 
1               5                   10                  15      


Ile Tyr Ala Met Ser Met Val Leu Lys Met Leu Pro Ala Leu Gly Met 
            20                  25                  30          


Ala Cys Pro Pro Lys Cys Arg Cys Glu Lys Leu Leu Phe Tyr Cys Asp 
        35                  40                  45              


Ser Gln Gly Phe His Ser Val Pro Asn Ala Thr Asp Lys Gly Ser Leu 
    50                  55                  60                  


Gly Leu Ser Leu Arg His Asn His Ile Thr Glu Leu Glu Arg Asp Gln 
65                  70                  75                  80  


Phe Ala Ser Phe Ser Gln Leu Thr Trp Leu His Leu Asp His Asn Gln 
                85                  90                  95      


Ile Ser Thr Val Lys Glu Asp Ala Phe Gln Gly Leu Tyr Lys Leu Lys 
            100                 105                 110         


Glu Leu Ile Leu Ser Ser Asn Lys Ile Phe Tyr Leu Pro Asn Thr Thr 
        115                 120                 125             


Phe Thr Gln Leu Ile Asn Leu Gln Asn Leu Asp Leu Ser Phe Asn Gln 
    130                 135                 140                 


Leu Ser Ser Leu His Pro Glu Leu Phe Tyr Gly Leu Arg Lys Leu Gln 
145                 150                 155                 160 


Thr Leu His Leu Arg Ser Asn Ser Leu Arg Thr Ile Pro Val Arg Leu 
                165                 170                 175     


Phe Trp Asp Cys Arg Ser Leu Glu Phe Leu Asp Leu Ser Thr Asn Arg 
            180                 185                 190         


Leu Arg Ser Leu Ala Arg Asn Gly Phe Ala Gly Leu Ile Lys Leu Arg 
        195                 200                 205             


Glu Leu His Leu Glu His Asn Gln Leu Thr Lys Ile Asn Phe Ala His 
    210                 215                 220                 


Phe Leu Arg Leu Ser Ser Leu His Thr Leu Phe Leu Gln Trp Asn Lys 
225                 230                 235                 240 


Ile Ser Asn Leu Thr Cys Gly Met Glu Trp Thr Trp Gly Thr Leu Glu 
                245                 250                 255     


Lys Leu Asp Leu Thr Gly Asn Glu Ile Lys Ala Ile Asp Leu Thr Val 
            260                 265                 270         


Phe Glu Thr Met Pro Asn Leu Lys Ile Leu Leu Met Asp Asn Asn Lys 
        275                 280                 285             


Leu Asn Ser Leu Asp Ser Lys Ile Leu Asn Ser Leu Arg Ser Leu Thr 
    290                 295                 300                 


Thr Val Gly Leu Ser Gly Asn Leu Trp Glu Cys Ser Ala Arg Ile Cys 
305                 310                 315                 320 


Ala Leu Ala Ser Trp Leu Gly Ser Phe Gln Gly Arg Trp Glu His Ser 
                325                 330                 335     


Ile Leu Cys His Ser Pro Asp His Thr Gln Gly Glu Asp Ile Leu Asp 
            340                 345                 350         


Ala Val His Gly Phe Gln Leu Cys Trp Asn Leu Ser Thr Thr Val Thr 
        355                 360                 365             


Val Met Ala Thr Thr Tyr Arg Asp Pro Thr Thr Glu Tyr Thr Lys Arg 
    370                 375                 380                 


Ile Ser Ser Ser Ser Tyr His Val Gly Asp Lys Glu Ile Pro Thr Thr 
385                 390                 395                 400 


Ala Gly Ile Ala Val Thr Thr Glu Glu His Phe Pro Glu Pro Asp Asn 
                405                 410                 415     


Ala Ile Phe Thr Gln Arg Val Ile Thr Gly Thr Met Ala Leu Leu Phe 
            420                 425                 430         


Ser Phe Phe Phe Ile Ile Phe Ile Val Phe Ile Ser Arg Lys Cys Cys 
        435                 440                 445             


Pro Pro Thr Leu Arg Arg Ile Arg Gln Cys Ser Met Val Gln Asn His 
    450                 455                 460                 


Arg Gln Leu Arg Ser Gln Thr Arg Leu His Met Ser Asn Met Ser Asp 
465                 470                 475                 480 


Gln Gly Pro Tyr Asn Glu Tyr Glu Pro Thr His Glu Gly Pro Phe Ile 
                485                 490                 495     


Ile Ile Asn Gly Tyr Gly Gln Cys Lys Cys Gln Gln Leu Pro Tyr Lys 
            500                 505                 510         


Glu Cys Glu Val 
        515     


<210>  4680
<211>  4558
<212>  DNA
<213>  Homosapiens

<400>  4680
ccgcggccgc ccgcgctccc gcccccggcc cttgcctgcc acgccctccc ctttttggcc     60

gggtcttggc tgctccgcgg gtctcgggcg ggatgtggga gtaagcgtgc cccctccccg    120

cacatgtctc agtgggtgcg tttctgggga gcggagggga gggaagacct cgggcaggca    180

gaggggtgca gggcgcgccc ctggaacaga ctgggctctg tgtgggccac aactgcgacg    240

tttgaacgga ccagcgtcat gttaggtctg ctcaacgttc cgagaagggc cagggccccg    300

ctccggtgtt cctcaactat tcatccctgt tttggatggg aggggatccc taaaaattag    360

cgcttcaaaa tacccaccat ttcgtgctcc ctctgcagtt aagtttggta ctctaggact    420

tgagagtgat tgcgagggca gagagacctc taggggtgat ctgattcgac cttcttcccc    480

tccgctccac cccaccacct ttttttcttt tttttttttg gtcggtgagt gatgatgata    540

agctcccgct gcaggtgtga atagagaccc cggaggtgcg tcctagccct catctgggga    600

agcgcacctg catacagacg ggtgcaccgg ggaggaggcg acctgccgcg tgttcctgca    660

agcagaaaag gagttaacta gtgtcacatt tgaagacgag cactgaggat gaggaaccaa    720

ctgaagaata tgaaaatgtt ggaaatgcag catctaagtg gccaaaagtg gaggatccta    780

tgcctgaatc taaggttggt gacacatgtg tttgggatag caaggtagag aatcaacaga    840

aaaagcctgt ggaaaacagg atgaaggagg acaaaagcag catcagggaa gcaatcagca    900

aagccaagag tacagcaaat ataaagacag aacaggaagg tgaggcatct gagaagagct    960

tgcatctgag cccacagcat atcacacacc agactatgcc tataggacag agaggcagtg   1020

agcaaggcaa acgtgtggag aacattaatg gaacctccta ccctagtcta cagcagaaaa   1080

ccaatgctgt taagaaatta cataaatgtg atgaatgtgg gaaatccttc aaatataatt   1140

cccgccttgt tcaacataaa attatgcaca ctggggaaaa gcgctatgaa tgtgatgact   1200

gtggagggac tttccggagc agctcgagcc ttcgggtcca caaacggatc cacactgggg   1260

agaagccgta caagtgtgag gaatgtggga aagcctacat gtcctactcc agccttataa   1320

accacaaaag cacccattct ggggagaaga actgtaaatg tgatgaatgt ggaaaatcct   1380

tcaattatag ctctgttctg gaccagcata aaaggatcca cactggggag aagccctatg   1440

aatgtggtga gtgtgggaag gccttcagga acagctctgg gctcagagtc cacaaaagga   1500

tccacacggg ggagaagccc tatgaatgcg acatctgtgg gaaaaccttc agtaacagct   1560

ctggccttag ggtccataaa aggatccaca caggtgagaa accttacgaa tgtgatgagt   1620

gtgggaaggc cttcattact tgtagaacac ttctcaacca taaaagcatc cactttggag   1680

ataaacccta taaatgtgat gagtgtgaga aatcttttaa ttatagctct cttctcattc   1740

agcataaagt catccacact ggagagaaac cttatgaatg tgatgaatgt gggaaggctt   1800

tcaggaacag ctcaggcctc atagtgcata aaaggatcca cacaggagag aaaccttaca   1860

agtgtgatgt ctgtggcaaa gcattcagct atagctcagg cctcgcagtc cataaaagca   1920

ttcaccctgg gaagaaagcc catgaatgta aggagtgtgg gaaatccttt agttataact   1980

cactacttct tcaacacaga actattcata ccggagagag accttatgta tgtgatgtgt   2040

gtgggaaaac gttcagaaac aatgcaggcc tcaaagtcca caggaggctc catactgggg   2100

aaaaaccata taagtgtgat gtgtgtggga aagcctatat ctcacgctct agccttaaaa   2160

atcacaaagg aatccacctt ggggagaagc cctataaatg tagctattgt gagaaatcct   2220

tcaactacag ctctgccctt gaacagcata aaaggattca taccagggaa aaaccctttg   2280

ggtgtgatga gtgtggtaaa gctttcagaa ataattctgg ccttaaagta cataaacgaa   2340

tccacactgg ggaacgacct tacaaatgtg aagaatgtgg gaaagcatac atctctctct   2400

cgagccttat aaatcataaa agtgtacacc ctggggagaa gccctttaag tgtgacgagt   2460

gtgagaaggc cttcatcaca taccgaaccc ttacaaacca caaaaaagtt catcttgggg   2520

agaagcccta caaatgtgat gtgtgtgaga aatcttttaa ttacacatcg ctcctttctc   2580

agcacagaag ggtccacact agagagaaac cctatgaatg tgacaggtgt gagaaggtct   2640

tcagaaacaa ctcaagcctt aaagttcata aaagaatcca tactggggag aggccctatg   2700

aatgtgatgt gtgtggaaaa gcctacatct cacactcaag ccttattaac cataagagta   2760

cccaccctgg caggacaccc catacatgtg atgaatgtgg aaaagctttt ttctcaagca   2820

gaactcttat aagccataaa agagtccatc ttggggagaa acccttcaag tgtgttgagt   2880

gtgggaaatc tttcagttac agctctctcc tttctcagca caagaggatc cacacagggg   2940

agaaacccta tgtgtgtgat aggtgtggga aggccttcag gaacagctca ggcctcacag   3000

tgcataaaag gatccacaca ggtgagaaac cctatgaatg tgatgagtgt gggaaggcat   3060

acatctcaca ctcaagtctt atcaatcata aaagtgtcca ccaggggaag cagccctata   3120

attgtgagtg tgggaaatcc ttcaattata gatcagtcct tgaccagcac aaaaggatcc   3180

acactggaaa gaagccatac cgatgtaatg agtgtggtaa ggcttttaat atcagatcaa   3240

atctcaccaa gcataaaaga acccatactg gagaggaatc tttaaatgtg atatatgtgg   3300

gaagttatag tggcacatcc cagaagagaa cctatgaggg agggaatgcc ctggatgggg   3360

gcaggatgag gatgcctctg tagcaggcag agcttaccaa gtctctccga actcaaatgg   3420

aagaaatacc ttatgaatgt aagaatgtag ggggtcatgg cttgtaattt acacagtgta   3480

aatgaaacca tcctagagga ttatgaggaa tcctttctat gtgattttca atcatagcaa   3540

gcaagaaagg ctccagtgtc aaggtagttc agctcttaca ggatataaaa cagtccatac   3600

ttgagagaaa aacttagatc tgagtgatgg aatgtgaagc aaatcttcaa aatcagtaga   3660

catttctgga cataaaacac agatgaggaa agggcttcaa ttagaagtta cgtaatcacc   3720

atcagaaagt tcatgtttgg taaattctgt tactagaaat gtaggaaatt caggtatagc   3780

tttgaatccc aattacacat tggtcagtgg gaaaactaag ggcctccaac aggcaaattc   3840

agggaggata ggtttcaggg aatataaatt tatttaatat tagtggtctt taagtataaa   3900

cttgatgtaa ttggtttggg agggggcagt gatgatgact tctgaaacaa aatttggatt   3960

tccttttagg aaaagtagaa agcatagact tacaagtcta acaggagata ggagagagtc   4020

actcataaaa aatgcaaatt gatgaacgta ctattgtgat acattagttg aatggatgaa   4080

acttttttaa agtttcagat gaactcccat aatgaatgat gaatttgtga tgagggataa   4140

cctggaagtg gtattcacac attatgctac aataaaaggt tctaccgtgg agaggatttt   4200

gacacattca gtaactaatg gaacacaccg tcaacatgaa ttcgcacctt acatgacaga   4260

agtgattcag ggattcctat gaatagaaat gctgagaagg aacgcatttt attgcagaag   4320

ctaaaaagct aaagtaccag tcatctagag agaaggaaat taatgtttct taataatcct   4380

gttaaatgtt tgattgtttt tggaatgtgt tattgtaaag atgtcatgca ggacatgtat   4440

atgttgtctg ttgtaaaatg ttaacgaata ctttgttcag ggctcactct ctctttgtca   4500

tgaaagccag ctccttgtgg cgaggtaaag tggaattcca ataaagaaat tccttaaa     4558


<210>  4681
<211>  867
<212>  PRT
<213>  Homosapiens

<400>  4681

Met Pro Glu Ser Lys Val Gly Asp Thr Cys Val Trp Asp Ser Lys Val 
1               5                   10                  15      


Glu Asn Gln Gln Lys Lys Pro Val Glu Asn Arg Met Lys Glu Asp Lys 
            20                  25                  30          


Ser Ser Ile Arg Glu Ala Ile Ser Lys Ala Lys Ser Thr Ala Asn Ile 
        35                  40                  45              


Lys Thr Glu Gln Glu Gly Glu Ala Ser Glu Lys Ser Leu His Leu Ser 
    50                  55                  60                  


Pro Gln His Ile Thr His Gln Thr Met Pro Ile Gly Gln Arg Gly Ser 
65                  70                  75                  80  


Glu Gln Gly Lys Arg Val Glu Asn Ile Asn Gly Thr Ser Tyr Pro Ser 
                85                  90                  95      


Leu Gln Gln Lys Thr Asn Ala Val Lys Lys Leu His Lys Cys Asp Glu 
            100                 105                 110         


Cys Gly Lys Ser Phe Lys Tyr Asn Ser Arg Leu Val Gln His Lys Ile 
        115                 120                 125             


Met His Thr Gly Glu Lys Arg Tyr Glu Cys Asp Asp Cys Gly Gly Thr 
    130                 135                 140                 


Phe Arg Ser Ser Ser Ser Leu Arg Val His Lys Arg Ile His Thr Gly 
145                 150                 155                 160 


Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Tyr Met Ser Tyr 
                165                 170                 175     


Ser Ser Leu Ile Asn His Lys Ser Thr His Ser Gly Glu Lys Asn Cys 
            180                 185                 190         


Lys Cys Asp Glu Cys Gly Lys Ser Phe Asn Tyr Ser Ser Val Leu Asp 
        195                 200                 205             


Gln His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu 
    210                 215                 220                 


Cys Gly Lys Ala Phe Arg Asn Ser Ser Gly Leu Arg Val His Lys Arg 
225                 230                 235                 240 


Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asp Ile Cys Gly Lys Thr 
                245                 250                 255     


Phe Ser Asn Ser Ser Gly Leu Arg Val His Lys Arg Ile His Thr Gly 
            260                 265                 270         


Glu Lys Pro Tyr Glu Cys Asp Glu Cys Gly Lys Ala Phe Ile Thr Cys 
        275                 280                 285             


Arg Thr Leu Leu Asn His Lys Ser Ile His Phe Gly Asp Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Asp Glu Cys Glu Lys Ser Phe Asn Tyr Ser Ser Leu Leu Ile 
305                 310                 315                 320 


Gln His Lys Val Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asp Glu 
                325                 330                 335     


Cys Gly Lys Ala Phe Arg Asn Ser Ser Gly Leu Ile Val His Lys Arg 
            340                 345                 350         


Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Val Cys Gly Lys Ala 
        355                 360                 365             


Phe Ser Tyr Ser Ser Gly Leu Ala Val His Lys Ser Ile His Pro Gly 
    370                 375                 380                 


Lys Lys Ala His Glu Cys Lys Glu Cys Gly Lys Ser Phe Ser Tyr Asn 
385                 390                 395                 400 


Ser Leu Leu Leu Gln His Arg Thr Ile His Thr Gly Glu Arg Pro Tyr 
                405                 410                 415     


Val Cys Asp Val Cys Gly Lys Thr Phe Arg Asn Asn Ala Gly Leu Lys 
            420                 425                 430         


Val His Arg Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Val 
        435                 440                 445             


Cys Gly Lys Ala Tyr Ile Ser Arg Ser Ser Leu Lys Asn His Lys Gly 
    450                 455                 460                 


Ile His Leu Gly Glu Lys Pro Tyr Lys Cys Ser Tyr Cys Glu Lys Ser 
465                 470                 475                 480 


Phe Asn Tyr Ser Ser Ala Leu Glu Gln His Lys Arg Ile His Thr Arg 
                485                 490                 495     


Glu Lys Pro Phe Gly Cys Asp Glu Cys Gly Lys Ala Phe Arg Asn Asn 
            500                 505                 510         


Ser Gly Leu Lys Val His Lys Arg Ile His Thr Gly Glu Arg Pro Tyr 
        515                 520                 525             


Lys Cys Glu Glu Cys Gly Lys Ala Tyr Ile Ser Leu Ser Ser Leu Ile 
    530                 535                 540                 


Asn His Lys Ser Val His Pro Gly Glu Lys Pro Phe Lys Cys Asp Glu 
545                 550                 555                 560 


Cys Glu Lys Ala Phe Ile Thr Tyr Arg Thr Leu Thr Asn His Lys Lys 
                565                 570                 575     


Val His Leu Gly Glu Lys Pro Tyr Lys Cys Asp Val Cys Glu Lys Ser 
            580                 585                 590         


Phe Asn Tyr Thr Ser Leu Leu Ser Gln His Arg Arg Val His Thr Arg 
        595                 600                 605             


Glu Lys Pro Tyr Glu Cys Asp Arg Cys Glu Lys Val Phe Arg Asn Asn 
    610                 615                 620                 


Ser Ser Leu Lys Val His Lys Arg Ile His Thr Gly Glu Arg Pro Tyr 
625                 630                 635                 640 


Glu Cys Asp Val Cys Gly Lys Ala Tyr Ile Ser His Ser Ser Leu Ile 
                645                 650                 655     


Asn His Lys Ser Thr His Pro Gly Arg Thr Pro His Thr Cys Asp Glu 
            660                 665                 670         


Cys Gly Lys Ala Phe Phe Ser Ser Arg Thr Leu Ile Ser His Lys Arg 
        675                 680                 685             


Val His Leu Gly Glu Lys Pro Phe Lys Cys Val Glu Cys Gly Lys Ser 
    690                 695                 700                 


Phe Ser Tyr Ser Ser Leu Leu Ser Gln His Lys Arg Ile His Thr Gly 
705                 710                 715                 720 


Glu Lys Pro Tyr Val Cys Asp Arg Cys Gly Lys Ala Phe Arg Asn Ser 
                725                 730                 735     


Ser Gly Leu Thr Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr 
            740                 745                 750         


Glu Cys Asp Glu Cys Gly Lys Ala Tyr Ile Ser His Ser Ser Leu Ile 
        755                 760                 765             


Asn His Lys Ser Val His Gln Gly Lys Gln Pro Tyr Asn Cys Glu Cys 
    770                 775                 780                 


Gly Lys Ser Phe Asn Tyr Arg Ser Val Leu Asp Gln His Lys Arg Ile 
785                 790                 795                 800 


His Thr Gly Lys Lys Pro Tyr Arg Cys Asn Glu Cys Gly Lys Ala Phe 
                805                 810                 815     


Asn Ile Arg Ser Asn Leu Thr Lys His Lys Arg Thr His Thr Gly Glu 
            820                 825                 830         


Glu Ser Leu Asn Val Ile Tyr Val Gly Ser Tyr Ser Gly Thr Ser Gln 
        835                 840                 845             


Lys Arg Thr Tyr Glu Gly Gly Asn Ala Leu Asp Gly Gly Arg Met Arg 
    850                 855                 860                 


Met Pro Leu 
865         


<210>  4682
<211>  2938
<212>  DNA
<213>  Homosapiens

<400>  4682
tgcaggtgtg aatagagacc ccggaggtgc gtcctagccc tcatctgggg aagcgcacct     60

gcatacagac gggtgcaccg gggaggaggc gacctgccgc gtgttcctgc aagcagaaaa    120

ggagttaact agtgtcacat ttgaagacga gcactgagga tgaggaacca actgaagaat    180

atgaaaatgt tggaaatgca gcatctaagt ggccaaaagt ggaggatcct atgcctgaat    240

ctaaggttgg tgacacatgt gtttgggata gcaaggtaga gaatcaacag aaaaagcctg    300

tggaaaacag gatgaaggag gacaaaagca gcatcaggga agcaatcagc aaagccaaga    360

gtacagcaaa tataaagaca gaacaggaag gtgaggcatc tgagaagagc ttgcatctga    420

gcccacagca tatcacacac cagactatgc ctataggaca gagaggcagt gagcaaggca    480

aacgtgtgga gaacattaat ggaacctcct accctagtct acagcagaaa accaatgctg    540

ttaagaaatt acataaatgt gatgaatgtg ggaaatcctt caaatataat tcccgccttg    600

ttcaacataa aattatgcac actggggaaa agcgctatga atgtgatgac tgtggaggga    660

ctttccggag cagctcgagc cttcgggtcc acaaacggat ccacactggg gagaagccgt    720

acaagtgtga ggaatgtggg aaagcctaca tgtcctactc cagccttata aaccacaaaa    780

gcacccattc tggggagaag aactgtaaat gtgatgaatg tggaaaatcc ttcaattata    840

gctctgttct ggaccagcat aaaaggatcc acactgggga gaagccctat gaatgtggtg    900

agtgtgggaa ggccttcagg aacagctctg ggctcagagt ccacaaaagg atccacacgg    960

gggagaagcc ctatgaatgc gacatctgtg ggaaaacctt cagtaacagc tctggcctta   1020

gggtccataa aaggatccac acaggtgaga aaccttacga atgtgatgag tgtgggaagg   1080

ccttcattac ttgtagaaca cttctcaacc ataaaagcat ccactttgga gataaaccct   1140

ataaatgtga tgagtgtgag aaatctttta attatagctc tcttctcatt cagcataaag   1200

tcatccacac tggagagaaa ccttatgaat gtgatgaatg tgggaaggct ttcaggaaca   1260

gctcaggcct catagtgcat aaaaggatcc acacaggaga gaaaccttac aagtgtgatg   1320

tctgtggcaa agcattcagc tatagctcag gcctcgcagt ccataaaagc attcaccctg   1380

ggaagaaagc ccatgaatgt aaggagtgtg ggaaatcctt tagttataac tcactacttc   1440

ttcaacacag aactattcat accggagaga gaccttatgt atgtgatgtg tgtgggaaaa   1500

cgttcagaaa caatgcaggc ctcaaagtcc acaggaggct ccatactggg gaaaaaccat   1560

ataagtgtga tgtgtgtggg aaagcctata tctcacgctc tagccttaaa aatcacaaag   1620

gaatccacct tggggagaag ccctataaat gtagctattg tgagaaatcc ttcaactaca   1680

gctctgccct tgaacagcat aaaaggattc ataccaggga aaaacccttt gggtgtgatg   1740

agtgtggtaa agctttcaga aataattctg gccttaaagt acataaacga atccacactg   1800

gggaacgacc ttacaaatgt gaagaatgtg ggaaagcata catctctctc tcgagcctta   1860

taaatcataa aagtgtacac cctggggaga agccctttaa gtgtgacgag tgtgagaagg   1920

ccttcatcac ataccgaacc cttacaaacc acaaaaaagt tcatcttggg gagaagccct   1980

acaaatgtga tgtgtgtgag aaatctttta attacacatc gctcctttct cagcacagaa   2040

gggtccacac tagagagaaa ccctatgaat gtgacaggtg tgagaaggtc ttcagaaaca   2100

actcaagcct taaagttcat aaaagaatcc atactgggga gaggccctat gaatgtgatg   2160

tgtgtggaaa agcctacatc tcacactcaa gccttattaa ccataagagt acccaccctg   2220

gcaggacacc ccatacatgt gatgaatgtg gaaaagcttt tttctcaagc agaactctta   2280

taagccataa aagagtccat cttggggaga aacccttcaa gtgtgttgag tgtgggaaat   2340

ctttcagtta cagctctctc ctttctcagc acaagaggat ccacacaggg gagaaaccct   2400

atgtgtgtga taggtgtggg aaggccttca ggaacagctc aggcctcaca gtgcataaaa   2460

ggatccacac agtttcagat gaactcccat aatgaatgat gaatttgtga tgagggataa   2520

cctggaagtg gtattcacac attatgctac aataaaaggt tctaccgtgg agaggatttt   2580

gacacattca gtaactaatg gaacacaccg tcaacatgaa ttcgcacctt acatgacaga   2640

agtgattcag ggattcctat gaatagaaat gctgagaagg aacgcatttt attgcagaag   2700

ctaaaaagct aaagtaccag tcatctagag agaaggaaat taatgtttct taataatcct   2760

gttaaatgtt tgattgtttt tggaatgtgt tattgtaaag atgtcatgca ggacatgtat   2820

atgttgtctg ttgtaaaatg ttaacgaata ctttgttcag ggctcactct ctctttgtca   2880

tgaaagccag ctccttgtgg cgaggtaaag tggaattcca ataaagaaat tccttaaa     2938


<210>  4683
<211>  753
<212>  PRT
<213>  Homosapiens

<400>  4683

Met Pro Glu Ser Lys Val Gly Asp Thr Cys Val Trp Asp Ser Lys Val 
1               5                   10                  15      


Glu Asn Gln Gln Lys Lys Pro Val Glu Asn Arg Met Lys Glu Asp Lys 
            20                  25                  30          


Ser Ser Ile Arg Glu Ala Ile Ser Lys Ala Lys Ser Thr Ala Asn Ile 
        35                  40                  45              


Lys Thr Glu Gln Glu Gly Glu Ala Ser Glu Lys Ser Leu His Leu Ser 
    50                  55                  60                  


Pro Gln His Ile Thr His Gln Thr Met Pro Ile Gly Gln Arg Gly Ser 
65                  70                  75                  80  


Glu Gln Gly Lys Arg Val Glu Asn Ile Asn Gly Thr Ser Tyr Pro Ser 
                85                  90                  95      


Leu Gln Gln Lys Thr Asn Ala Val Lys Lys Leu His Lys Cys Asp Glu 
            100                 105                 110         


Cys Gly Lys Ser Phe Lys Tyr Asn Ser Arg Leu Val Gln His Lys Ile 
        115                 120                 125             


Met His Thr Gly Glu Lys Arg Tyr Glu Cys Asp Asp Cys Gly Gly Thr 
    130                 135                 140                 


Phe Arg Ser Ser Ser Ser Leu Arg Val His Lys Arg Ile His Thr Gly 
145                 150                 155                 160 


Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Tyr Met Ser Tyr 
                165                 170                 175     


Ser Ser Leu Ile Asn His Lys Ser Thr His Ser Gly Glu Lys Asn Cys 
            180                 185                 190         


Lys Cys Asp Glu Cys Gly Lys Ser Phe Asn Tyr Ser Ser Val Leu Asp 
        195                 200                 205             


Gln His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu 
    210                 215                 220                 


Cys Gly Lys Ala Phe Arg Asn Ser Ser Gly Leu Arg Val His Lys Arg 
225                 230                 235                 240 


Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asp Ile Cys Gly Lys Thr 
                245                 250                 255     


Phe Ser Asn Ser Ser Gly Leu Arg Val His Lys Arg Ile His Thr Gly 
            260                 265                 270         


Glu Lys Pro Tyr Glu Cys Asp Glu Cys Gly Lys Ala Phe Ile Thr Cys 
        275                 280                 285             


Arg Thr Leu Leu Asn His Lys Ser Ile His Phe Gly Asp Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Asp Glu Cys Glu Lys Ser Phe Asn Tyr Ser Ser Leu Leu Ile 
305                 310                 315                 320 


Gln His Lys Val Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asp Glu 
                325                 330                 335     


Cys Gly Lys Ala Phe Arg Asn Ser Ser Gly Leu Ile Val His Lys Arg 
            340                 345                 350         


Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Val Cys Gly Lys Ala 
        355                 360                 365             


Phe Ser Tyr Ser Ser Gly Leu Ala Val His Lys Ser Ile His Pro Gly 
    370                 375                 380                 


Lys Lys Ala His Glu Cys Lys Glu Cys Gly Lys Ser Phe Ser Tyr Asn 
385                 390                 395                 400 


Ser Leu Leu Leu Gln His Arg Thr Ile His Thr Gly Glu Arg Pro Tyr 
                405                 410                 415     


Val Cys Asp Val Cys Gly Lys Thr Phe Arg Asn Asn Ala Gly Leu Lys 
            420                 425                 430         


Val His Arg Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Val 
        435                 440                 445             


Cys Gly Lys Ala Tyr Ile Ser Arg Ser Ser Leu Lys Asn His Lys Gly 
    450                 455                 460                 


Ile His Leu Gly Glu Lys Pro Tyr Lys Cys Ser Tyr Cys Glu Lys Ser 
465                 470                 475                 480 


Phe Asn Tyr Ser Ser Ala Leu Glu Gln His Lys Arg Ile His Thr Arg 
                485                 490                 495     


Glu Lys Pro Phe Gly Cys Asp Glu Cys Gly Lys Ala Phe Arg Asn Asn 
            500                 505                 510         


Ser Gly Leu Lys Val His Lys Arg Ile His Thr Gly Glu Arg Pro Tyr 
        515                 520                 525             


Lys Cys Glu Glu Cys Gly Lys Ala Tyr Ile Ser Leu Ser Ser Leu Ile 
    530                 535                 540                 


Asn His Lys Ser Val His Pro Gly Glu Lys Pro Phe Lys Cys Asp Glu 
545                 550                 555                 560 


Cys Glu Lys Ala Phe Ile Thr Tyr Arg Thr Leu Thr Asn His Lys Lys 
                565                 570                 575     


Val His Leu Gly Glu Lys Pro Tyr Lys Cys Asp Val Cys Glu Lys Ser 
            580                 585                 590         


Phe Asn Tyr Thr Ser Leu Leu Ser Gln His Arg Arg Val His Thr Arg 
        595                 600                 605             


Glu Lys Pro Tyr Glu Cys Asp Arg Cys Glu Lys Val Phe Arg Asn Asn 
    610                 615                 620                 


Ser Ser Leu Lys Val His Lys Arg Ile His Thr Gly Glu Arg Pro Tyr 
625                 630                 635                 640 


Glu Cys Asp Val Cys Gly Lys Ala Tyr Ile Ser His Ser Ser Leu Ile 
                645                 650                 655     


Asn His Lys Ser Thr His Pro Gly Arg Thr Pro His Thr Cys Asp Glu 
            660                 665                 670         


Cys Gly Lys Ala Phe Phe Ser Ser Arg Thr Leu Ile Ser His Lys Arg 
        675                 680                 685             


Val His Leu Gly Glu Lys Pro Phe Lys Cys Val Glu Cys Gly Lys Ser 
    690                 695                 700                 


Phe Ser Tyr Ser Ser Leu Leu Ser Gln His Lys Arg Ile His Thr Gly 
705                 710                 715                 720 


Glu Lys Pro Tyr Val Cys Asp Arg Cys Gly Lys Ala Phe Arg Asn Ser 
                725                 730                 735     


Ser Gly Leu Thr Val His Lys Arg Ile His Thr Val Ser Asp Glu Leu 
            740                 745                 750         


Pro 
    


<210>  4684
<211>  2456
<212>  DNA
<213>  Homosapiens

<400>  4684
ggccgtgcgg tccgcgcttt tgtcccgctg gcggccgggt tcccgcggcg ccgccacagc     60

cagtacgtga gtccgcggcc gcccgcgctc ccgcccccgg cccttgcctg ccacgccctc    120

ccctttttgg ccgggtcttg gctgctccgc gggtctcggg cgggatgtgg gagtaagcgt    180

gccccctccc cgcacatgtc tcagtgggtg cgtttctggg gagcggaggg gagggaagac    240

ctcgggcagg cagaggggtg cagggcgcgc ccctggaaca gactgggctc tgtgtgggcc    300

acaactgcga cgtttgaacg gaccagcgtc atgttaggtc tgctcaacgt tccgagaagg    360

gccagggccc cgctccggtg ttcctcaact attcatccct gttttggatg ggaggggatc    420

cctaaaaatt agcgcttcaa aatacccacc atttcgtgct ccctctgcag ttaagtttgg    480

tactctagga cttgagagtg attgcgaggg cagagagacc tctaggggtg atctgattcg    540

accttcttcc cctccgctcc accccaccac ctttttttct tttttttttt tggtcggtga    600

gtgatgatga taagctcccg ctgcaggtgt gaatagagac cccggaggtg cgtcctagcc    660

ctcatctggg gaagcgcacc tgcatacaga cgggtgcacc ggggaggagg cgacctgccg    720

cgtgttcctg caagcagaaa aggagttaac taggttgcct tcttcctcat ctctgcagta    780

actgtcttca tggtttcata gccttctccc tgatacccct ccccagtgtc acatttgaag    840

acgagcactg aggatgagga accaactgaa gaatatgaaa atgttggaaa tgcagcatct    900

aagtggccaa aagtggagga tcctatgcct gaatctaagg ttggtgacac atgtgtttgg    960

gatagcaagg tagagaatca acagaaaaag cctgtggaaa acaggatgaa ggaggacaaa   1020

agcagcatca gggaagcaat cagcaaagcc aagagtacag caaatataaa gacagaacag   1080

gaaggtgagg catctgagaa gagcttgcat ctgagcccac agcatatcac acaccagact   1140

atgcctatag gacagagagg cagtgagcaa ggcaaacgtg tggagaacat taatggaacc   1200

tcctacccta gtctacagca gaaaaccaat gctgttaaga aattacataa atgtgatgaa   1260

tgtgggaaat ccttcaaata taattcccgc cttgttcaac ataaaattat gcacactggg   1320

gaaaagcgct atgaatgtga tgactgtgga gggactttcc ggagcagctc gagccttcgg   1380

gtccacaaac ggatccacac tggggagaag ccgtacaagt gtgaggaatg tgggaaagcc   1440

tacatgtcct actccagcct tataaaccac aaaagcaccc attctgggga gaagaactgt   1500

aaatgtgatg aatgtggaaa atccttcaat tatagctctg ttctggacca gcataaaagg   1560

atccacactg gggagaagcc ctatgaatgt ggtgagtgtg ggaaggcctt caggaacagc   1620

tctgggctca gagtccacaa aaggatccac acgggggaga agccctatga atgcgacatc   1680

tgtgggaaaa ccttcagtaa cagctctggc cttagggtcc ataaaaggat ccacacaggt   1740

gagaaacctt acgaatgtga tgagtgtggg aaggccttca ttacttgtag aacacttctc   1800

aaccataaaa gcatccactt tggagataaa ccctataaat gtgatgagtg tgagaaatct   1860

tttaattata gctctcttct cattcagcat aaagtcatcc acactggaga gaaaccctat   1920

gtgtgtgata ggtgtgggaa ggccttcagg aacagctcag gcctcacagt gcataaaagg   1980

atccacacag tttcagatga actcccataa tgaatgatga atttgtgatg agggataacc   2040

tggaagtggt attcacacat tatgctacaa taaaaggttc taccgtggag aggattttga   2100

cacattcagt aactaatgga acacaccgtc aacatgaatt cgcaccttac atgacagaag   2160

tgattcaggg attcctatga atagaaatgc tgagaaggaa cgcattttat tgcagaagct   2220

aaaaagctaa agtaccagtc atctagagag aaggaaatta atgtttctta ataatcctgt   2280

taaatgtttg attgtttttg gaatgtgtta ttgtaaagat gtcatgcagg acatgtatat   2340

gttgtctgtt gtaaaatgtt aacgaatact ttgttcaggg ctcactctct ctttgtcatg   2400

aaagccagct ccttgtggcg aggtaaagtg gaattccaat aaagaaattc cttaaa       2456


<210>  4685
<211>  361
<212>  PRT
<213>  Homosapiens

<400>  4685

Met Pro Glu Ser Lys Val Gly Asp Thr Cys Val Trp Asp Ser Lys Val 
1               5                   10                  15      


Glu Asn Gln Gln Lys Lys Pro Val Glu Asn Arg Met Lys Glu Asp Lys 
            20                  25                  30          


Ser Ser Ile Arg Glu Ala Ile Ser Lys Ala Lys Ser Thr Ala Asn Ile 
        35                  40                  45              


Lys Thr Glu Gln Glu Gly Glu Ala Ser Glu Lys Ser Leu His Leu Ser 
    50                  55                  60                  


Pro Gln His Ile Thr His Gln Thr Met Pro Ile Gly Gln Arg Gly Ser 
65                  70                  75                  80  


Glu Gln Gly Lys Arg Val Glu Asn Ile Asn Gly Thr Ser Tyr Pro Ser 
                85                  90                  95      


Leu Gln Gln Lys Thr Asn Ala Val Lys Lys Leu His Lys Cys Asp Glu 
            100                 105                 110         


Cys Gly Lys Ser Phe Lys Tyr Asn Ser Arg Leu Val Gln His Lys Ile 
        115                 120                 125             


Met His Thr Gly Glu Lys Arg Tyr Glu Cys Asp Asp Cys Gly Gly Thr 
    130                 135                 140                 


Phe Arg Ser Ser Ser Ser Leu Arg Val His Lys Arg Ile His Thr Gly 
145                 150                 155                 160 


Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Tyr Met Ser Tyr 
                165                 170                 175     


Ser Ser Leu Ile Asn His Lys Ser Thr His Ser Gly Glu Lys Asn Cys 
            180                 185                 190         


Lys Cys Asp Glu Cys Gly Lys Ser Phe Asn Tyr Ser Ser Val Leu Asp 
        195                 200                 205             


Gln His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu 
    210                 215                 220                 


Cys Gly Lys Ala Phe Arg Asn Ser Ser Gly Leu Arg Val His Lys Arg 
225                 230                 235                 240 


Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asp Ile Cys Gly Lys Thr 
                245                 250                 255     


Phe Ser Asn Ser Ser Gly Leu Arg Val His Lys Arg Ile His Thr Gly 
            260                 265                 270         


Glu Lys Pro Tyr Glu Cys Asp Glu Cys Gly Lys Ala Phe Ile Thr Cys 
        275                 280                 285             


Arg Thr Leu Leu Asn His Lys Ser Ile His Phe Gly Asp Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Asp Glu Cys Glu Lys Ser Phe Asn Tyr Ser Ser Leu Leu Ile 
305                 310                 315                 320 


Gln His Lys Val Ile His Thr Gly Glu Lys Pro Tyr Val Cys Asp Arg 
                325                 330                 335     


Cys Gly Lys Ala Phe Arg Asn Ser Ser Gly Leu Thr Val His Lys Arg 
            340                 345                 350         


Ile His Thr Val Ser Asp Glu Leu Pro 
        355                 360     


<210>  4686
<211>  2770
<212>  DNA
<213>  Homosapiens

<400>  4686
tggagggact ttccggagca gctcgagcct tcgggtccac aaacggatcc acactgggga     60

gaagccgtac aagtgtgagg aatgtgggaa agcctacatg tcctactcca gccttataaa    120

ccacaaaagc acccattctg gggagaagaa ctgtaaatgt gatgaatgtg gaaaatcctt    180

caattatagc tctgttctgg accagcataa aaggatccac actggggaga agccctatga    240

atgtggtgag tgtgggaagg ccttcaggaa cagctctggg ctcagagtcc acaaaaggat    300

ccacacgggg gagaagccct atgaatgcga catctgtggg aaaaccttca gtaacagctc    360

tggccttagg gtccataaaa ggatccacac aggtgagaaa ccttacgaat gtgatgagtg    420

tgggaaggcc ttcattactt gtagaacact tctcaaccat aaaagcatcc actttggaga    480

taaaccctat aaatgtgatg agttgtggta aagctttcag aaataattct ggccttaaag    540

tacataaacg aatccacact ggggaacgac cttacaaatg tgaagaatgt gggaaagcat    600

acatctctct ctcgagcctt ataaatcata aaagtgtaca ccctggggag aagcccttta    660

agtgtgacga gtgtgagaag gccttcatca cataccgaac ccttacaaac cacaaaaaag    720

ttcatcttgg ggagaagccc tacaaatgtg atgtgtgtga gaaatctttt aattacacat    780

cgctcctttc tcagcacaga agggtccaca ctagagagaa accctatgaa tgtgacaggt    840

gtgagaaggt cttcagaaac aactcaagcc ttaaagttca taaaagaatc catactgggg    900

agaggcccta tgaatgtgat gtgtgtggaa aagcctacat ctcacactca agccttatta    960

accataagag tacccaccct ggcaggacac cccatacatg tgatgaatgt ggaaaagctt   1020

ttttctcaag cagaactctt ataagccata aaagagtcca tcttggggag aaacccttca   1080

agtgtgttga gtgtgggaaa tctttcagtt acagctctct cctttctcag cacaagagga   1140

tccacacagg ggagaaaccc tatgtgtgtg ataggtgtgg gaaggccttc aggaacagct   1200

caggcctcac agtgcataaa aggatccaca caggtgagaa accctatgaa tgtgatgagt   1260

gtgggaaggc atacatctca cactcaagtc ttatcaatca taaaagtgtc caccagggga   1320

agcagcccta taattgtgag tgtgggaaat ccttcaatta tagatcagtc cttgaccagc   1380

acaaaaggat ccacactgga aagaagccat accgatgtaa tgagtgtggt aaggctttta   1440

atatcagatc aaatctcacc aagcataaaa gaacccatac tggagaggaa tctttaaatg   1500

tgatatatgt gggaagttat agtggcacat cccagaagag aacctatgag ggagggaatg   1560

ccctggatgg gggcaggatg aggatgcctc tgtagcaggc agagcttacc aagtctctcc   1620

gaactcaaat ggaagaaata ccttatgaat gtaagaatgt agggggtcat ggcttgtaat   1680

ttacacagtg taaatgaaac catcctagag gattatgagg aatcctttct atgtgatttt   1740

caatcatagc aagcaagaaa ggctccagtg tcaaggtagt tcagctctta caggatataa   1800

aacagtccat acttgagaga aaaacttaga tctgagtgat ggaatgtgaa gcaaatcttc   1860

aaaatcagta gacatttctg gacataaaac acagatgagg aaagggcttc aattagaagt   1920

tacgtaatca ccatcagaaa gttcatgttt ggtaaattct gttactagaa atgtaggaaa   1980

ttcaggtata gctttgaatc ccaattacac attggtcagt gggaaaacta agggcctcca   2040

acaggcaaat tcagggagga taggtttcag ggaatataaa tttatttaat attagtggtc   2100

tttaagtata aacttgatgt aattggtttg ggagggggca gtgatgatga cttctgaaac   2160

aaaatttgga tttcctttta ggaaaagtag aaagcataga cttacaagtc taacaggaga   2220

taggagagag tcactcataa aaaatgcaaa ttgatgaacg tactattgtg atacattagt   2280

tgaatggatg aaactttttt aaagtttcag atgaactccc ataatgaatg atgaatttgt   2340

gatgagggat aacctggaag tggtattcac acattatgct acaataaaag gttctaccgt   2400

ggagaggatt ttgacacatt cagtaactaa tggaacacac cgtcaacatg aattcgcacc   2460

ttacatgaca gaagtgattc agggattcct atgaatagaa atgctgagaa ggaacgcatt   2520

ttattgcaga agctaaaaag ctaaagtacc agtcatctag agagaaggaa attaatgttt   2580

cttaataatc ctgttaaatg tttgattgtt tttggaatgt gttattgtaa agatgtcatg   2640

caggacatgt atatgttgtc tgttgtaaaa tgttaacgaa tactttgttc agggctcact   2700

ctctctttgt catgaaagcc agctccttgt ggcgaggtaa agtggaattc caataaagaa   2760

attccttaaa                                                          2770


<210>  4687
<211>  477
<212>  PRT
<213>  Homosapiens

<400>  4687

Met Asn Val Glu Asn Pro Ser Ile Ile Ala Leu Phe Trp Thr Ser Ile 
1               5                   10                  15      


Lys Gly Ser Thr Leu Gly Arg Ser Pro Met Asn Val Val Ser Val Gly 
            20                  25                  30          


Arg Pro Ser Gly Thr Ala Leu Gly Ser Glu Ser Thr Lys Gly Ser Thr 
        35                  40                  45              


Arg Gly Arg Ser Pro Met Asn Ala Thr Ser Val Gly Lys Pro Ser Val 
    50                  55                  60                  


Thr Ala Leu Ala Leu Gly Ser Ile Lys Gly Ser Thr Gln Val Arg Asn 
65                  70                  75                  80  


Leu Thr Asn Val Met Ser Val Gly Arg Pro Ser Leu Leu Val Glu His 
                85                  90                  95      


Phe Ser Thr Ile Lys Ala Ser Thr Leu Glu Ile Asn Pro Ile Asn Val 
            100                 105                 110         


Met Ser Cys Gly Lys Ala Phe Arg Asn Asn Ser Gly Leu Lys Val His 
        115                 120                 125             


Lys Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly 
    130                 135                 140                 


Lys Ala Tyr Ile Ser Leu Ser Ser Leu Ile Asn His Lys Ser Val His 
145                 150                 155                 160 


Pro Gly Glu Lys Pro Phe Lys Cys Asp Glu Cys Glu Lys Ala Phe Ile 
                165                 170                 175     


Thr Tyr Arg Thr Leu Thr Asn His Lys Lys Val His Leu Gly Glu Lys 
            180                 185                 190         


Pro Tyr Lys Cys Asp Val Cys Glu Lys Ser Phe Asn Tyr Thr Ser Leu 
        195                 200                 205             


Leu Ser Gln His Arg Arg Val His Thr Arg Glu Lys Pro Tyr Glu Cys 
    210                 215                 220                 


Asp Arg Cys Glu Lys Val Phe Arg Asn Asn Ser Ser Leu Lys Val His 
225                 230                 235                 240 


Lys Arg Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Asp Val Cys Gly 
                245                 250                 255     


Lys Ala Tyr Ile Ser His Ser Ser Leu Ile Asn His Lys Ser Thr His 
            260                 265                 270         


Pro Gly Arg Thr Pro His Thr Cys Asp Glu Cys Gly Lys Ala Phe Phe 
        275                 280                 285             


Ser Ser Arg Thr Leu Ile Ser His Lys Arg Val His Leu Gly Glu Lys 
    290                 295                 300                 


Pro Phe Lys Cys Val Glu Cys Gly Lys Ser Phe Ser Tyr Ser Ser Leu 
305                 310                 315                 320 


Leu Ser Gln His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys 
                325                 330                 335     


Asp Arg Cys Gly Lys Ala Phe Arg Asn Ser Ser Gly Leu Thr Val His 
            340                 345                 350         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asp Glu Cys Gly 
        355                 360                 365             


Lys Ala Tyr Ile Ser His Ser Ser Leu Ile Asn His Lys Ser Val His 
    370                 375                 380                 


Gln Gly Lys Gln Pro Tyr Asn Cys Glu Cys Gly Lys Ser Phe Asn Tyr 
385                 390                 395                 400 


Arg Ser Val Leu Asp Gln His Lys Arg Ile His Thr Gly Lys Lys Pro 
                405                 410                 415     


Tyr Arg Cys Asn Glu Cys Gly Lys Ala Phe Asn Ile Arg Ser Asn Leu 
            420                 425                 430         


Thr Lys His Lys Arg Thr His Thr Gly Glu Glu Ser Leu Asn Val Ile 
        435                 440                 445             


Tyr Val Gly Ser Tyr Ser Gly Thr Ser Gln Lys Arg Thr Tyr Glu Gly 
    450                 455                 460                 


Gly Asn Ala Leu Asp Gly Gly Arg Met Arg Met Pro Leu 
465                 470                 475         


<210>  4688
<211>  1487
<212>  DNA
<213>  Homosapiens

<400>  4688
atgttgccca aagatctggc ccatcaggtt gacaccaaat taaccgtcac acccgtctcc     60

tactccgccc tcatcagcca gccgccttta gggcctcctg ggtgtggctt catggtgaca    120

agactggagg aggcccaggc atcacatagg aggacgcagg aagaggcatc cagtcacaac    180

cagaccatca tgcttcagaa gagctattgt tcggagaata acctgccaca ggctaccttc    240

cacacccaca gaccctgggc agtcccatgt aagtgtcagt cagaactcct gacacagaca    300

tctccctttc cacaggaccc agaaatgata acaggtagac tcgtagagga gaattgctgc    360

ggcaaagagt acgtgcacgt ccatccacac cgcacgctgc cttccctgga ggccctgggt    420

ttggaagccg acaccggcgg tggggtgggc agggggcgag gtcgctgcca agctggcgcc    480

ccgggtggga gcgtggcccg gtcccaggga cggctccagg ggcgcgctcc cactccgcat    540

ccccagtgcc taaccggggg cgcttctggt gctgacgacc aggaagggct ggcccccact    600

tccgggaacg tccccgcacc cacacctggc aatgaatcac gtgttcagga accagccgag    660

gaggcgctcc cctccctccc tcccgccggc gccgtcggcc cggaccatcg agtcagtcct    720

ccagcgtccc agagagggcg cggaagtgcc ccagggccgg cgcgggttct tccggccgtg    780

cggtccgcgc ttttgtcccg ctggcggccg ggttcccgcg gcgccgccac agccagttgc    840

cttcttcctc atctctgcag taactgtctt catggtttca tagccttctc cctgataccc    900

ctccccagtg tcacatttga agacgagcac tgaggatgag gaaccaactg aagaatatga    960

aaatgttgga aatgcagcat ctaagtggcc aaaagtggag gatcctatgc ctgaatctaa   1020

gtttcagatg aactcccata atgaatgatg aatttgtgat gagggataac ctggaagtgg   1080

tattcacaca ttatgctaca ataaaaggtt ctaccgtgga gaggattttg acacattcag   1140

taactaatgg aacacaccgt caacatgaat tcgcacctta catgacagaa gtgattcagg   1200

gattcctatg aatagaaatg ctgagaagga acgcatttta ttgcagaagc taaaaagcta   1260

aagtaccagt catctagaga gaaggaaatt aatgtttctt aataatcctg ttaaatgttt   1320

gattgttttt ggaatgtgtt attgtaaaga tgtcatgcag gacatgtata tgttgtctgt   1380

tgtaaaatgt taacgaatac tttgttcagg gctcactctc tctttgtcat gaaagccagc   1440

tccttgtggc gaggtaaagt ggaattccaa taaagaaatt ccttaaa                 1487


<210>  4689
<211>  310
<212>  PRT
<213>  Homosapiens

<400>  4689

Met Leu Pro Lys Asp Leu Ala His Gln Val Asp Thr Lys Leu Thr Val 
1               5                   10                  15      


Thr Pro Val Ser Tyr Ser Ala Leu Ile Ser Gln Pro Pro Leu Gly Pro 
            20                  25                  30          


Pro Gly Cys Gly Phe Met Val Thr Arg Leu Glu Glu Ala Gln Ala Ser 
        35                  40                  45              


His Arg Arg Thr Gln Glu Glu Ala Ser Ser His Asn Gln Thr Ile Met 
    50                  55                  60                  


Leu Gln Lys Ser Tyr Cys Ser Glu Asn Asn Leu Pro Gln Ala Thr Phe 
65                  70                  75                  80  


His Thr His Arg Pro Trp Ala Val Pro Cys Lys Cys Gln Ser Glu Leu 
                85                  90                  95      


Leu Thr Gln Thr Ser Pro Phe Pro Gln Asp Pro Glu Met Ile Thr Gly 
            100                 105                 110         


Arg Leu Val Glu Glu Asn Cys Cys Gly Lys Glu Tyr Val His Val His 
        115                 120                 125             


Pro His Arg Thr Leu Pro Ser Leu Glu Ala Leu Gly Leu Glu Ala Asp 
    130                 135                 140                 


Thr Gly Gly Gly Val Gly Arg Gly Arg Gly Arg Cys Gln Ala Gly Ala 
145                 150                 155                 160 


Pro Gly Gly Ser Val Ala Arg Ser Gln Gly Arg Leu Gln Gly Arg Ala 
                165                 170                 175     


Pro Thr Pro His Pro Gln Cys Leu Thr Gly Gly Ala Ser Gly Ala Asp 
            180                 185                 190         


Asp Gln Glu Gly Leu Ala Pro Thr Ser Gly Asn Val Pro Ala Pro Thr 
        195                 200                 205             


Pro Gly Asn Glu Ser Arg Val Gln Glu Pro Ala Glu Glu Ala Leu Pro 
    210                 215                 220                 


Ser Leu Pro Pro Ala Gly Ala Val Gly Pro Asp His Arg Val Ser Pro 
225                 230                 235                 240 


Pro Ala Ser Gln Arg Gly Arg Gly Ser Ala Pro Gly Pro Ala Arg Val 
                245                 250                 255     


Leu Pro Ala Val Arg Ser Ala Leu Leu Ser Arg Trp Arg Pro Gly Ser 
            260                 265                 270         


Arg Gly Ala Ala Thr Ala Ser Cys Leu Leu Pro His Leu Cys Ser Asn 
        275                 280                 285             


Cys Leu His Gly Phe Ile Ala Phe Ser Leu Ile Pro Leu Pro Ser Val 
    290                 295                 300                 


Thr Phe Glu Asp Glu His 
305                 310 


<210>  4690
<211>  1487
<212>  DNA
<213>  Homosapiens

<400>  4690
atgttgccca aagatctggc ccatcaggtt gacaccaaat taaccgtcac acccgtctcc     60

tactccgccc tcatcagcca gccgccttta gggcctcctg ggtgtggctt catggtgaca    120

agactggagg aggcccaggc atcacatagg aggacgcagg aagaggcatc cagtcacaac    180

cagaccatca tgcttcagaa gagctattgt tcggagaata acctgccaca ggctaccttc    240

cacacccaca gaccctgggc agtcccatgt aagtgtcagt cagaactcct gacacagaca    300

tctccctttc cacaggaccc agaaatgata acaggtagac tcgtagagga gaattgctgc    360

ggcaaagagt acgtgcacgt ccatccacac cgcacgctgc cttccctgga ggccctgggt    420

ttggaagccg acaccggcgg tggggtgggc agggggcgag gtcgctgcca agctggcgcc    480

ccgggtggga gcgtggcccg gtcccaggga cggctccagg ggcgcgctcc cactccgcat    540

ccccagtgcc taaccggggg cgcttctggt gctgacgacc aggaagggct ggcccccact    600

tccgggaacg tccccgcacc cacacctggc aatgaatcac gtgttcagga accagccgag    660

gaggcgctcc cctccctccc tcccgccggc gccgtcggcc cggaccatcg agtcagtcct    720

ccagcgtccc agagagggcg cggaagtgcc ccagggccgg cgcgggttct tccggccgtg    780

cggtccgcgc ttttgtcccg ctggcggccg ggtttccgcg gcgccgccac agccagttgc    840

cttcttcctc atctctgcag taactgtctt catggtttca tagccttctc cctgataccc    900

ctccccagtg tcacatttga agacgagcac tgaggatgag gaaccaactg aagaatatga    960

aaatgttgga aatgcagcat ctaagtggcc aaaagtggag gatcctatgc ctgaatctaa   1020

gtttcagatg aactcccata atgaatgatg aatttgtgat gagggataac ctggaagtgg   1080

tattcacaca ttatgctaca ataaaaggtt ctaccgtgga gaggattttg acacattcag   1140

taactaatgg aacacaccgt caacatgaat tcgcacctta catgacagaa gtgattcagg   1200

gattcctatg aatagaaatg ctgagaagga acgcatttta ttgcagaagc taaaaagcta   1260

aagtaccagt catctagaga gaaggaaatt aatgtttctt aataatcctg ttaaatgttt   1320

gattgttttt ggaatgtgtt attgtaaaga tgtcatgcag gacatgtata tgttgtctgt   1380

tgtaaaatgt taacgaatac tttgttcagg gctcactctc tctttgtcat gaaagccagc   1440

tccttgtggc gaggtaaagt ggaattccaa taaagaaatt ccttaaa                 1487


<210>  4691
<211>  310
<212>  PRT
<213>  Homosapiens

<400>  4691

Met Leu Pro Lys Asp Leu Ala His Gln Val Asp Thr Lys Leu Thr Val 
1               5                   10                  15      


Thr Pro Val Ser Tyr Ser Ala Leu Ile Ser Gln Pro Pro Leu Gly Pro 
            20                  25                  30          


Pro Gly Cys Gly Phe Met Val Thr Arg Leu Glu Glu Ala Gln Ala Ser 
        35                  40                  45              


His Arg Arg Thr Gln Glu Glu Ala Ser Ser His Asn Gln Thr Ile Met 
    50                  55                  60                  


Leu Gln Lys Ser Tyr Cys Ser Glu Asn Asn Leu Pro Gln Ala Thr Phe 
65                  70                  75                  80  


His Thr His Arg Pro Trp Ala Val Pro Cys Lys Cys Gln Ser Glu Leu 
                85                  90                  95      


Leu Thr Gln Thr Ser Pro Phe Pro Gln Asp Pro Glu Met Ile Thr Gly 
            100                 105                 110         


Arg Leu Val Glu Glu Asn Cys Cys Gly Lys Glu Tyr Val His Val His 
        115                 120                 125             


Pro His Arg Thr Leu Pro Ser Leu Glu Ala Leu Gly Leu Glu Ala Asp 
    130                 135                 140                 


Thr Gly Gly Gly Val Gly Arg Gly Arg Gly Arg Cys Gln Ala Gly Ala 
145                 150                 155                 160 


Pro Gly Gly Ser Val Ala Arg Ser Gln Gly Arg Leu Gln Gly Arg Ala 
                165                 170                 175     


Pro Thr Pro His Pro Gln Cys Leu Thr Gly Gly Ala Ser Gly Ala Asp 
            180                 185                 190         


Asp Gln Glu Gly Leu Ala Pro Thr Ser Gly Asn Val Pro Ala Pro Thr 
        195                 200                 205             


Pro Gly Asn Glu Ser Arg Val Gln Glu Pro Ala Glu Glu Ala Leu Pro 
    210                 215                 220                 


Ser Leu Pro Pro Ala Gly Ala Val Gly Pro Asp His Arg Val Ser Pro 
225                 230                 235                 240 


Pro Ala Ser Gln Arg Gly Arg Gly Ser Ala Pro Gly Pro Ala Arg Val 
                245                 250                 255     


Leu Pro Ala Val Arg Ser Ala Leu Leu Ser Arg Trp Arg Pro Gly Phe 
            260                 265                 270         


Arg Gly Ala Ala Thr Ala Ser Cys Leu Leu Pro His Leu Cys Ser Asn 
        275                 280                 285             


Cys Leu His Gly Phe Ile Ala Phe Ser Leu Ile Pro Leu Pro Ser Val 
    290                 295                 300                 


Thr Phe Glu Asp Glu His 
305                 310 


<210>  4692
<211>  381
<212>  DNA
<213>  Homosapiens

<400>  4692
atggcggagg aggtttcact ggttggagca gagggagcaa ctatggctgc ggaagtcctg     60

gaggcagcct ccgcggagga gcagaaggaa aaggaagata aagtgactag tccagagaaa    120

gctgaagaag caaaattaaa agcaaggtat cctcatctgg gacaaaagcc tggaggttca    180

gatttcttaa ggaaacgatt gcagaaaggg caaaaatatt ttgattctgg gcattacaac    240

agggctaaag caaaaacgaa gagcaagcaa cttcctactg cagctccaga taagacggag    300

gtcactggtg accacattcc tactccacag gaccttcctc aacggaaacc atcccttgtt    360

gctaacaagc tggctggctg a                                              381


<210>  4693
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  4693

Met Ala Glu Glu Val Ser Leu Val Gly Ala Glu Gly Ala Thr Met Ala 
1               5                   10                  15      


Ala Glu Val Leu Glu Ala Ala Ser Ala Glu Glu Gln Lys Glu Lys Glu 
            20                  25                  30          


Asp Lys Val Thr Ser Pro Glu Lys Ala Glu Glu Ala Lys Leu Lys Ala 
        35                  40                  45              


Arg Tyr Pro His Leu Gly Gln Lys Pro Gly Gly Ser Asp Phe Leu Arg 
    50                  55                  60                  


Lys Arg Leu Gln Lys Gly Gln Lys Tyr Phe Asp Ser Gly His Tyr Asn 
65                  70                  75                  80  


Arg Ala Lys Ala Lys Thr Lys Ser Lys Gln Leu Pro Thr Ala Ala Pro 
                85                  90                  95      


Asp Lys Thr Glu Val Thr Gly Asp His Ile Pro Thr Pro Gln Asp Leu 
            100                 105                 110         


Pro Gln Arg Lys Pro Ser Leu Val Ala Asn Lys Leu Ala Gly 
        115                 120                 125     


<210>  4694
<211>  381
<212>  DNA
<213>  Homosapiens

<400>  4694
atggcggagg aggtttcact ggttggagca gagggagcaa ctatggctgc ggaagtcctg     60

gaggcagcct ccgcggagga gcagaaggaa aaggaagata aagtgactag tccagagaaa    120

gctgaagaag caaaattaaa agcaaggtat cctcatctgg gacaaaagcc tggaggttca    180

gatttcttaa ggaaacgatt gcagaaaggg caaaaatatt ttgattctgg gcattacaac    240

agggctaaag caaaaacgaa gagcaagcaa cttcctactg cagctccaga taagacggag    300

gtcactggtg accacattcc tactccacag gaccttcctc aacggaaacc atcccttgtt    360

gctaacaagc tggctggctg a                                              381


<210>  4695
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  4695

Met Ala Glu Glu Val Ser Leu Val Gly Ala Glu Gly Ala Thr Met Ala 
1               5                   10                  15      


Ala Glu Val Leu Glu Ala Ala Ser Ala Glu Glu Gln Lys Glu Lys Glu 
            20                  25                  30          


Asp Lys Val Thr Ser Pro Glu Lys Ala Glu Glu Ala Lys Leu Lys Ala 
        35                  40                  45              


Arg Tyr Pro His Leu Gly Gln Lys Pro Gly Gly Ser Asp Phe Leu Arg 
    50                  55                  60                  


Lys Arg Leu Gln Lys Gly Gln Lys Tyr Phe Asp Ser Gly His Tyr Asn 
65                  70                  75                  80  


Arg Ala Lys Ala Lys Thr Lys Ser Lys Gln Leu Pro Thr Ala Ala Pro 
                85                  90                  95      


Asp Lys Thr Glu Val Thr Gly Asp His Ile Pro Thr Pro Gln Asp Leu 
            100                 105                 110         


Pro Gln Arg Lys Pro Ser Leu Val Ala Asn Lys Leu Ala Gly 
        115                 120                 125     


<210>  4696
<211>  159
<212>  DNA
<213>  Homosapiens

<400>  4696
atgtggatca ccagtctcat caccatgaag gatgaagata tatttgattt ggcaggggat     60

ccccaagaca gcctcattcc tgggccttct cccaccccca agcaaaaccc agtttgtaat    120

gaggctttct ttggacacca gactttctcc ttaaggtaa                           159


<210>  4697
<211>  52
<212>  PRT
<213>  Homosapiens

<400>  4697

Met Trp Ile Thr Ser Leu Ile Thr Met Lys Asp Glu Asp Ile Phe Asp 
1               5                   10                  15      


Leu Ala Gly Asp Pro Gln Asp Ser Leu Ile Pro Gly Pro Ser Pro Thr 
            20                  25                  30          


Pro Lys Gln Asn Pro Val Cys Asn Glu Ala Phe Phe Gly His Gln Thr 
        35                  40                  45              


Phe Ser Leu Arg 
    50          


<210>  4698
<211>  279
<212>  DNA
<213>  Homosapiens

<400>  4698
atggacagga ctgtcattca gaaataccac actgtgaatg gccacagctg tgaagttagg     60

aaagccctgt caaagcaaga gatggttagt gcttcatcca gccaaagagg tcgaagtggt    120

tctggaaact ttgctggtgg tcttagaagt ggtttcagtg ggaataacaa ctttggtcgt    180

ggaggaaact tccgtggtcg tggggccttt ggtggcagcc gtggtggtgg tggatatgat    240

ggcagtgggg atggctataa tggatatggt aacgattga                           279


<210>  4699
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  4699

Met Asp Arg Thr Val Ile Gln Lys Tyr His Thr Val Asn Gly His Ser 
1               5                   10                  15      


Cys Glu Val Arg Lys Ala Leu Ser Lys Gln Glu Met Val Ser Ala Ser 
            20                  25                  30          


Ser Ser Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Ala Gly Gly Leu 
        35                  40                  45              


Arg Ser Gly Phe Ser Gly Asn Asn Asn Phe Gly Arg Gly Gly Asn Phe 
    50                  55                  60                  


Arg Gly Arg Gly Ala Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Asp 
65                  70                  75                  80  


Gly Ser Gly Asp Gly Tyr Asn Gly Tyr Gly Asn Asp 
                85                  90          


<210>  4700
<211>  216
<212>  DNA
<213>  Homosapiens

<400>  4700
atgcctcgcc tacccgggct ctgtcctcaa ctctgccacc accgctgcgt ggccctgctc     60

gccctgcagc ccgacccctg ccttgcccac tctgagcctc cgcgccagcc catgtatgcc    120

atggaaatat ggctgttgga attctggtgt tttacgacct tcttaacacc gtctgcgtat    180

gtgctaagca gtctgagcca gttcagaaag gagtaa                              216


<210>  4701
<211>  71
<212>  PRT
<213>  Homosapiens

<400>  4701

Met Pro Arg Leu Pro Gly Leu Cys Pro Gln Leu Cys His His Arg Cys 
1               5                   10                  15      


Val Ala Leu Leu Ala Leu Gln Pro Asp Pro Cys Leu Ala His Ser Glu 
            20                  25                  30          


Pro Pro Arg Gln Pro Met Tyr Ala Met Glu Ile Trp Leu Leu Glu Phe 
        35                  40                  45              


Trp Cys Phe Thr Thr Phe Leu Thr Pro Ser Ala Tyr Val Leu Ser Ser 
    50                  55                  60                  


Leu Ser Gln Phe Arg Lys Glu 
65                  70      


<210>  4702
<211>  681
<212>  DNA
<213>  Homosapiens

<400>  4702
atgagccctc tcacctatcg tggacaccga ggaaacgcag cagagatggg cacccaggct     60

gcccagatcc tctggcagcc tcgggtgctc gtccacttcg ctcctcctcc gcctttgctg    120

ccgcagccgc aggtgcgcac cccaccgcgt ccctgcttcc ctcctcgagc tcttgtggtc    180

gagctcagac tgggcgacag agcgtgtgag gagacgattg aaaaacccaa aaagaagaaa    240

aagcaaaagc cccaggagat tcatcaggag aatggaatgg aagacccatc tatctctttc    300

tccaaaccca agaaaaagaa atctttttcc aaggaggagt tgatgagtag cgatcttgaa    360

gagaccgctg gcagcaccag tcttcccaag aggaagaagt cttcacccaa ggaggaaaca    420

gttaatgaca ccgaagagtc aggccacaga agtggctcca agaaaacgag gaaattctcc    480

aaagaggagc tggtcagcag tgggcctgaa gaggcggctg gcaagagcag ctccaagaag    540

aagaaaaagt tccataaagc atcccaggaa gattagaatg caaatggaca ttctctggga    600

ggtggggcat accatagccc aaggcgacat ttcccaccct gtgccgtctt ccccaataag    660

aacaaattca caaaaaagag a                                              681


<210>  4703
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  4703

Met Ser Pro Leu Thr Tyr Arg Gly His Arg Gly Asn Ala Ala Glu Met 
1               5                   10                  15      


Gly Thr Gln Ala Ala Gln Ile Leu Trp Gln Pro Arg Val Leu Val His 
            20                  25                  30          


Phe Ala Pro Pro Pro Pro Leu Leu Pro Gln Pro Gln Val Arg Thr Pro 
        35                  40                  45              


Pro Arg Pro Cys Phe Pro Pro Arg Ala Leu Val Val Glu Leu Arg Leu 
    50                  55                  60                  


Gly Asp Arg Ala Cys Glu Glu Thr Ile Glu Lys Pro Lys Lys Lys Lys 
65                  70                  75                  80  


Lys Gln Lys Pro Gln Glu Ile His Gln Glu Asn Gly Met Glu Asp Pro 
                85                  90                  95      


Ser Ile Ser Phe Ser Lys Pro Lys Lys Lys Lys Ser Phe Ser Lys Glu 
            100                 105                 110         


Glu Leu Met Ser Ser Asp Leu Glu Glu Thr Ala Gly Ser Thr Ser Leu 
        115                 120                 125             


Pro Lys Arg Lys Lys Ser Ser Pro Lys Glu Glu Thr Val Asn Asp Thr 
    130                 135                 140                 


Glu Glu Ser Gly His Arg Ser Gly Ser Lys Lys Thr Arg Lys Phe Ser 
145                 150                 155                 160 


Lys Glu Glu Leu Val Ser Ser Gly Pro Glu Glu Ala Ala Gly Lys Ser 
                165                 170                 175     


Ser Ser Lys Lys Lys Lys Lys Phe His Lys Ala Ser Gln Glu Asp 
            180                 185                 190     


<210>  4704
<211>  879
<212>  DNA
<213>  Homosapiens

<400>  4704
atgatcaatg atagttactt tggttggctt atgctccttg ggttccctgg gaagcctcag     60

ctggagatga tcatctctgg ggttgtcttt ttcttctatg caatttcttt gatgggaaat    120

atggtcctta tcctgctgcc attactggat aaacatctcc aaacccccat atatttcttt    180

cttagaaatc tggctatctt ggatctttgt tacaccacaa atatagtccc acagatgttg    240

gtcaatgcct ggggtaaaga caagaaaatc acttttggtg gctgtgcttt tcaacttttc    300

actaatgtga cgctatgcac ggttgaatgt atgcttctgg ctgtgatgtc atatgaccca    360

ttcaatgctg tctgcaagcc tctggactat atgaccataa tgaaccccca actctgtcaa    420

ggcctggtgg ccatgacctg gttaattggt gtcactaatt gcatgatact ttccccctgt    480

cctgtgagtc ttcctcgatg cggagaccac cacctggatc actatttttg tgaaatatct    540

gcaatggtca aaattgcatg tggggctacc acagtcatgg aggaaactaa accttatttg    600

cattgtgttg ttgttgttgt tttcattttc cttgcatcac ttcttctcat tcttgtgtca    660

tatggcttca ttgctatggc tgtactcaag atcaagtctg cagcaggaag acaaaaagca    720

tttgggacct gtttctccca tctcattgtg gtatccatct tctatgggac tgttagatat    780

aggtatatag agccaggaaa cagtccatct caggatgagg gcaaacttct ccatatattt    840

tactccattg ttactcccac cttgaaccca tcccactaa                           879


<210>  4705
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  4705

Met Ile Asn Asp Ser Tyr Phe Gly Trp Leu Met Leu Leu Gly Phe Pro 
1               5                   10                  15      


Gly Lys Pro Gln Leu Glu Met Ile Ile Ser Gly Val Val Phe Phe Phe 
            20                  25                  30          


Tyr Ala Ile Ser Leu Met Gly Asn Met Val Leu Ile Leu Leu Pro Leu 
        35                  40                  45              


Leu Asp Lys His Leu Gln Thr Pro Ile Tyr Phe Phe Leu Arg Asn Leu 
    50                  55                  60                  


Ala Ile Leu Asp Leu Cys Tyr Thr Thr Asn Ile Val Pro Gln Met Leu 
65                  70                  75                  80  


Val Asn Ala Trp Gly Lys Asp Lys Lys Ile Thr Phe Gly Gly Cys Ala 
                85                  90                  95      


Phe Gln Leu Phe Thr Asn Val Thr Leu Cys Thr Val Glu Cys Met Leu 
            100                 105                 110         


Leu Ala Val Met Ser Tyr Asp Pro Phe Asn Ala Val Cys Lys Pro Leu 
        115                 120                 125             


Asp Tyr Met Thr Ile Met Asn Pro Gln Leu Cys Gln Gly Leu Val Ala 
    130                 135                 140                 


Met Thr Trp Leu Ile Gly Val Thr Asn Cys Met Ile Leu Ser Pro Cys 
145                 150                 155                 160 


Pro Val Ser Leu Pro Arg Cys Gly Asp His His Leu Asp His Tyr Phe 
                165                 170                 175     


Cys Glu Ile Ser Ala Met Val Lys Ile Ala Cys Gly Ala Thr Thr Val 
            180                 185                 190         


Met Glu Glu Thr Lys Pro Tyr Leu His Cys Val Val Val Val Val Phe 
        195                 200                 205             


Ile Phe Leu Ala Ser Leu Leu Leu Ile Leu Val Ser Tyr Gly Phe Ile 
    210                 215                 220                 


Ala Met Ala Val Leu Lys Ile Lys Ser Ala Ala Gly Arg Gln Lys Ala 
225                 230                 235                 240 


Phe Gly Thr Cys Phe Ser His Leu Ile Val Val Ser Ile Phe Tyr Gly 
                245                 250                 255     


Thr Val Arg Tyr Arg Tyr Ile Glu Pro Gly Asn Ser Pro Ser Gln Asp 
            260                 265                 270         


Glu Gly Lys Leu Leu His Ile Phe Tyr Ser Ile Val Thr Pro Thr Leu 
        275                 280                 285             


Asn Pro Ser His 
    290         


<210>  4706
<211>  486
<212>  DNA
<213>  Homosapiens

<400>  4706
atgagccata cgggaggtga gtggttggtg gacaggcagg tggtcttctc cctgacagtg     60

ctggtggccc tctgtggact ggtaggcaat gatgtgatct gctggcttct ctactcacag    120

gtctggagca gcccctatgt gacctacatc cttaacctgg ccactgttga tatggtcaac    180

ctctcctgtg taactgtgat cctgctggag aaaatcctca tgctgtatca ccaggcggca    240

ttgcaggtgg ctgtgtttct ggatcctgtc tcctatttct ccgacacagt gggtctctgt    300

ctcctggtgg ccatgagtat tgagagcttt ctctgtgccc tctgtcccac ctggtgctgc    360

caccgcccag agcacacctc tgccatggtg aggtgggccc tggccctttc tttgtatgca    420

gttagccagg tctgtgagta ctgggagaag tgcttggcat gtgaccaatt tcatgaggct    480

ttatga                                                               486


<210>  4707
<211>  161
<212>  PRT
<213>  Homosapiens

<400>  4707

Met Ser His Thr Gly Gly Glu Trp Leu Val Asp Arg Gln Val Val Phe 
1               5                   10                  15      


Ser Leu Thr Val Leu Val Ala Leu Cys Gly Leu Val Gly Asn Asp Val 
            20                  25                  30          


Ile Cys Trp Leu Leu Tyr Ser Gln Val Trp Ser Ser Pro Tyr Val Thr 
        35                  40                  45              


Tyr Ile Leu Asn Leu Ala Thr Val Asp Met Val Asn Leu Ser Cys Val 
    50                  55                  60                  


Thr Val Ile Leu Leu Glu Lys Ile Leu Met Leu Tyr His Gln Ala Ala 
65                  70                  75                  80  


Leu Gln Val Ala Val Phe Leu Asp Pro Val Ser Tyr Phe Ser Asp Thr 
                85                  90                  95      


Val Gly Leu Cys Leu Leu Val Ala Met Ser Ile Glu Ser Phe Leu Cys 
            100                 105                 110         


Ala Leu Cys Pro Thr Trp Cys Cys His Arg Pro Glu His Thr Ser Ala 
        115                 120                 125             


Met Val Arg Trp Ala Leu Ala Leu Ser Leu Tyr Ala Val Ser Gln Val 
    130                 135                 140                 


Cys Glu Tyr Trp Glu Lys Cys Leu Ala Cys Asp Gln Phe His Glu Ala 
145                 150                 155                 160 


Leu 
    


<210>  4708
<211>  576
<212>  DNA
<213>  Homosapiens

<400>  4708
atgagccata cgggaggtga gtggttggtg gacaggcagg tggtcttctc cctgacagtg     60

ctggtggccc tctgtggact ggtaggcaat gatgtgatct gctggcttct ctactcacag    120

gtctggagca gcccctatgt gacctacatc cttaacctgg ccactgttga tatggtcaac    180

ctctcctgtg taactgtgat cctgctggag aaaatcctca tgctgtatca ccaggcggca    240

ttgcaggtgg ctgtgtttct ggatcctgtc tcctatttct ccgacacagt gggtctctgt    300

ctcctggtgg ccatgagtat tgagagcttt ctctgtgccc tctgtcccac ctggtgctgc    360

caccgcccag agcacacctc tgccatgtgg tgttccccca tcaggaccta tcatgttgtc    420

tgctttgtga tcatcagctt cttcctttgg gtcctgccct tagttgtcct tgtgtgcctg    480

ccaggaaagt ttctgaccct tgcctttgac ctcctgttgc tactgtccat tgtggtcagc    540

atgcctcacc tagtcatcta cttcttggct gagtaa                              576


<210>  4709
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  4709

Met Ser His Thr Gly Gly Glu Trp Leu Val Asp Arg Gln Val Val Phe 
1               5                   10                  15      


Ser Leu Thr Val Leu Val Ala Leu Cys Gly Leu Val Gly Asn Asp Val 
            20                  25                  30          


Ile Cys Trp Leu Leu Tyr Ser Gln Val Trp Ser Ser Pro Tyr Val Thr 
        35                  40                  45              


Tyr Ile Leu Asn Leu Ala Thr Val Asp Met Val Asn Leu Ser Cys Val 
    50                  55                  60                  


Thr Val Ile Leu Leu Glu Lys Ile Leu Met Leu Tyr His Gln Ala Ala 
65                  70                  75                  80  


Leu Gln Val Ala Val Phe Leu Asp Pro Val Ser Tyr Phe Ser Asp Thr 
                85                  90                  95      


Val Gly Leu Cys Leu Leu Val Ala Met Ser Ile Glu Ser Phe Leu Cys 
            100                 105                 110         


Ala Leu Cys Pro Thr Trp Cys Cys His Arg Pro Glu His Thr Ser Ala 
        115                 120                 125             


Met Trp Cys Ser Pro Ile Arg Thr Tyr His Val Val Cys Phe Val Ile 
    130                 135                 140                 


Ile Ser Phe Phe Leu Trp Val Leu Pro Leu Val Val Leu Val Cys Leu 
145                 150                 155                 160 


Pro Gly Lys Phe Leu Thr Leu Ala Phe Asp Leu Leu Leu Leu Leu Ser 
                165                 170                 175     


Ile Val Val Ser Met Pro His Leu Val Ile Tyr Phe Leu Ala Glu 
            180                 185                 190     


<210>  4710
<211>  2965
<212>  DNA
<213>  Homosapiens

<400>  4710
cggacgcgtg ggtgcgagga aagcaaagtc tgggccatgg agatgagcct agtcctgctg     60

ttcctgatcc gcactgccct ttttgcaccc cagggagctg ctgctgagcc ccacagtctt    120

tgttacaacc tcacggtgct gtcccgggat ggatctgtgc agtcagggtt tctcgctgag    180

ggacatctgg atggtcagct cttcctgctc tgtgacaggc agaaaggcag ggcagggccc    240

cggggacagt gggcagaagc agtcctggga gctgagacct gggacacaga gactgaagac    300

ttgacagaga atgggcagga gctcaggagg accctggatc atatcaaggg ccagaaagga    360

ggaagaggag ataaatatat gaaggtgctg tttggcacag aatttaatag ggaagaaaga    420

gacagtataa ctcaccagtg ctgggtctca tcatcctgca atttcagaac aactatgaat    480

acaaaaagaa ttttaaaatc ccagtcctgc ctagaaaggg gaagtcatct ctaaatatgg    540

tggccctggg gcagctggcc tccctgccag gcctcttcca tgggggccct ttctgcagtg    600

actgtggttt cttcccattt tactctgtcc tgtgtcctga ctgaagcgac aaggtgtgtc    660

tgcagctgtg ctcacacctg gaggaaacct caatggtgac atgatgaccc tagcagcaca    720

tcctctttcc tgtgtcaaga agcatcgtcc ggggaggtga gaagaagaca gtcctcccta    780

gaattgaaga accagggaga agcagatggg ctgggcagat caagcacaaa cctgagatcc    840

aactgtccct cttatgcgcc tgggtttctt cactggacac cagtatgagt caactttcct    900

gtaaagcaga acaagcacga gattggacca tgttagagga ggaatggtgt catctccact    960

tctggagaga tccctgtccc cgtgttcggg ggaaggacca agcctcactc ccatgcagag   1020

aagaggctct gactgtaact gcacctgtgg agagtggaga gacaagaagt gtgagctatt   1080

tataaagctg agcacctgac tgccgcggga gtgaatagtg accacacaca gcaagacctg   1140

ggacatggca gtgactgtgt ccagaactga cagaactaat ctatcatatt agaaatcaag   1200

aaagtgtctg ctctagggtt ggggagggtg atttatgacc aagtagaacc cagtggtgtt   1260

tcctggaggc tggcaatgct attccttgat gtggctgcta tttacctgag tgttcacttt   1320

gtgaaaatcc acggcccact tatggtttgt ccacctttct ccatgcatgt tgtccttcat   1380

tcaagtatac attactgatg ttttgaaaca attctctcta agctaatata gaatctccat   1440

tactgaaagt ccttagaaat gctgcattgg aaaaaattag tccaattatt aaaaatctat   1500

gaaataaatg ctgtgactca gacattaaga ggagaatcta caacaagagc agtaggcttg   1560

ggagctaaca caagaacagc tttggaaatg gctgttgagc caggaactag gaatcaaaac   1620

ccaaaaaggc ccatgcaagg tggagggtgt gaaatgatgc cccagtagtg catgaatgaa   1680

tgagtcatgg gcagtggctc atgggttgct tggtcagtca ggaacttgag caaaataaag   1740

ttggaaaact gggggatgga agagagaggt atgcacagac ctcttgacat gggcagagct   1800

tcagaagatg gtggttgcag gtttccccaa atagagaaca tcaataaaaa ggtagaaatt   1860

ttacaaagag accagataaa aagtttggag ctgaaaagtg caataactga aatgaaaaat   1920

tcactagagg ggctccagag caaatttcac catgcagaat ggagaatcag caagcttgaa   1980

gataagacaa ttgaaattct ctagttcagt agcagaaaga aaaaaaatta tgaagaaaaa   2040

taaacagaac tttaaagatc tgtgagacaa catcaagcac atgcactttg ggagtcctca   2100

aagaaaggag agagagaaag gagaagaatg actatttaaa gaataactcc aaaccttcca   2160

aatttgatga aaaacattat tcatccaaca aacttgacaa attttaagca gcaaaaaaat   2220

ttaaatttaa agaggtccac accaagagaa cattataatc aacctgtcaa aagccaatga   2280

caaacagagc atattgaaat gaataacaga gaaggaactt ttcaggttca atggatcctc   2340

aataagattg cagcccagtt ttcttcagaa accatagagt tcagaaggca ctggaatgtt   2400

gacaaattta gaggtcagaa aaaaaaagac tgtcatgcag gaattgtgtg tctggaaaaa   2460

ctctccttca gaaataatgg attttatata tatataaata tatatatata tatatatata   2520

cacacatata tatacatata tatgactata catagtacca catatatata actatatata   2580

gtactactat gaaattatat atatagtact atatatagta gtcatactat aaaagctagt   2640

agtaatatgt atatttttgg tgtttatatg tgtgtgtgtg tgtgtgtgca tatatatata   2700

gtactatata tagtagtcct ataaaagcta gtagtaacat gtatattttt ggtgtttaat   2760

tcttcctttg tttttcctat ttggtttaaa agaaaatgcc cattgactaa tgaatgaata   2820

aacaacatgt agtgtatttc taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2940

aaaaaaataa aaaaaaaaaa aaaaa                                         2965


<210>  4711
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  4711

Met Glu Met Ser Leu Val Leu Leu Phe Leu Ile Arg Thr Ala Leu Phe 
1               5                   10                  15      


Ala Pro Gln Gly Ala Ala Ala Glu Pro His Ser Leu Cys Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Arg Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Gly His Leu Asp Gly Gln Leu Phe Leu Leu Cys Asp Arg Gln Lys Gly 
    50                  55                  60                  


Arg Ala Gly Pro Arg Gly Gln Trp Ala Glu Ala Val Leu Gly Ala Glu 
65                  70                  75                  80  


Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Glu Leu 
                85                  90                  95      


Arg Arg Thr Leu Asp His Ile Lys Gly Gln Lys Gly Gly Arg Gly Asp 
            100                 105                 110         


Lys Tyr Met Lys Val Leu Phe Gly Thr Glu Phe Asn Arg Glu Glu Arg 
        115                 120                 125             


Asp Ser Ile Thr His Gln Cys Trp Val Ser Ser Ser Cys Asn Phe Arg 
    130                 135                 140                 


Thr Thr Met Asn Thr Lys Arg Ile Leu Lys Ser Gln Ser Cys Leu Glu 
145                 150                 155                 160 


Arg Gly Ser His Leu 
                165 


<210>  4712
<211>  4556
<212>  DNA
<213>  Homosapiens

<400>  4712
ctgaggtagg cggatcacct gaggtcggca gtttgagacc agcctgacca acatggagag     60

accccatctc tactaaaaat acaaaattag ccaggtgtgg tggctcatgc ctgtaatccc    120

agctacttgg gaggccaagg caggagaatt gcttgaaccc aggaggcaga ggttgcagtg    180

agccgagatc acaccattgc actctagcct ggtgaaggag caagactcca tctcaaaaaa    240

aaaaaaaaaa aagaaagaaa gaaaaataca cattcagagg agacaaaaaa taaaaaacaa    300

tgatgcatgc ccacaggatc tagaaaataa cttcttaagg gcaaatctag gagttattgg    360

ccttaaagaa gagatagaga aagagatagg aatagaaagt ttgttgaaag ggataataac    420

atagaacttc ctaaacctac agaaagatat ttatatccaa gtacaagaag gttatagaac    480

accaggccaa tttaacccaa agattacctc aaggcattta ataatcaaac tcccacagga    540

caagggtaaa gaaaggatcc taaaagcagc aagagaaaag aaacagataa catacaatgg    600

agctccaata catctggcag tatatttttc agtggaaacc ttacaagcca ggagagagtg    660

acatgacata tgttaaagtg ctgaagggaa aaaacctttt accctagaat agtatatcca    720

gcaaaaatat ccttcaaaca tgaagaataa acaaagactt ccccagacaa acaaaagctg    780

agggatttca tcaacactag actggtccca taagaaacgc ttaagggagt actttggtca    840

gaaagaaaca gacattaatg agcaacaaag aatcatctaa aggtaaaaaa ctcactgtta    900

agagtaagta cacagaaaaa cccaaagtgt gataacattg taactgtggt gtgtaagtag    960

aaagaataaa tgataaacca atcaaaaata gtaactacaa cttttcaaga ccagtcagaa   1020

aaataagata aaattagaaa caacaaaaag ttaaaaagtg gggggatgaa gttaagatgt   1080

agagttttta ttagtttttt gtttgttaat gcaaacagtg ttaccaggtt aaaataatgg   1140

gttacaaaat agtatttgta atccttatgg taacctcaaa cctaaaaaca tacactggat   1200

acataaaaaa taaaaagcaa aaacctaaat catatcacca gagcaaacta ccttccctaa   1260

aggaagacag gaagaaaaga aagaagaaga ccacaaaaca accagaaaac aaataaataa   1320

caaggcagga gtaagtcttt acttatcgat aatacattga atggaaatat ggactaaact   1380

ctccaatcaa aagacataga ctggctgaat gaatggagaa aacaagaccc attgatctgt   1440

tgcctacaag aaacacactt aaactataaa gacacacata ggctgaaagt aaagagttgg   1500

aaagagttat tccatgccaa tggaaaccag gaaaaagaga aggagtattg attttgatac   1560

aaaaactatg agacaaataa agtcactata caatgataaa ggggttaata tggtttccat   1620

ttgtgcccca cccaaatttc gtgttctatt gtaatcctca atgttggagg tggggcctgg   1680

tgggacgtga ttagatcatg ggggtggatc tttcatgact aattcagcac catcttctta   1740

gtgctgttct catgatagtg agttcttctg aaatctggtt gcttaaaagt gtgtagcacc   1800

tctccacacc acccgcttgc cttggtctac tcctgctatg tagatgcttg ctcccacttt   1860

gcattattcc atgagtaaaa gctccctcag gccttcccag aatcagatgc cgctatgctt   1920

cctgaacagc ctgtggaact atgagccaat tcaacctctt ttcttcataa attaacaagt   1980

cttgggtatt tctttatagc agtgtgagaa cagaataata cagaaaattg gtaaagagga   2040

gtgaggcatt gctagaaaga tacctgaaaa tgtggaaaca gcagtggaac tgggaaatag   2100

acagaggttg gaagagtgtg gagggctccg aagataggaa gatgagggga agtttggaat   2160

ttcttagaga tttgttaaat tgttttgacc aaaatactga tggtgatatg gacaatgaag   2220

tccaggctga ggaggtctca gatggagatg agggacttat tgggacctgg agtgaaggtc   2280

acttttgtta ggacattgtg gttggagaca ttgtgcccct gccctaggaa tctgtggaac   2340

tttgaacttg agagcgaaga tttagggtat ctggcagaag aaatttctaa gcagcaaagc   2400

gttcaagacg tggcctggct gcttctggta gtctgtgctc atatttgtga gcaaagacat   2460

gacaagaaac tggaacttat atttaaaaag gaagcagagt gtaaaagttt ggagaatttg   2520

cagcctggcc atgttgtaga aaagaaaaaa accattttct ggagaggaat tcaagctagc   2580

tgcagaaaat tgcaagtaac aaggagcaaa atgttgatag ccaagatagt gggaaaaaca   2640

ccttgaaggc atttcagata ccttgggggc agcctctccc atcacaggcc caaaggccta   2700

ggagggaagg atggtttcct gggccaggct cagggtcctg ctgccctgca caacctcagg   2760

aaactgctct ccaaatccca gctgctccag ctccagcttc agctcaaagg gccccaggta   2820

tagctcaggc tgctgctcca taggatgcaa gttataagcc ttagtggctc ccgtgtggtg   2880

ttaaattaag cctgtaggtg cacagagtgc aagaattgag gcttgggagc ctccaactag   2940

atttcagagt atgtgtggga aagcctggat gtccaggcag aagccagctg cagggacaga   3000

gccctcatgg agaacctcta ctagggtagt gtggagggga aatttggggt tggagttccc   3060

acacagcttc ccctctggtg tactgcctag tggagctgtg agaagacagc cactgtcctc   3120

cagattccag gatgatagat ctgccaatga cagcttgcac tgtacaactg gaaaagccac   3180

aggcagtcaa tgccagcccg tgaaagcagt gacagtggct taccctgcaa agtcccaggg   3240

gctgagctgc ccaaggcctt gggagcccac cccttgcacc agtgtgccct ggatgtgaga   3300

tatggagtca aaggagagta ttttggagct ttaagattta atgactacct gctgggtttc   3360

agacttgcat gggtccagta gcccctttct tttggccaat ttctcacttt tggaatggga   3420

gtgtttaccc aattcctgta cccccactgt atgttggaag taactaactg tttttttatt   3480

ttgtaagctc acaggtggga gagacttgcc ttgtctcagg ttgagactct ggactttgga   3540

cttttgaatt aatgctggaa tgagttaaga ctttgaggga ctgttgggaa gatataactg   3600

tattttgcag tatgagaagg acatgagatt tgggagacac cagaggtgga ataatatgat   3660

ttggatctgc atccccacca aaatctcatg ttcaattgta atcctaaatt ttggaggttg   3720

agcctggtgg aagaggattg gataatgggg gtggtttctc atggtttaac accatccccc   3780

tgggtgctgt tctcatgaca gtgagtgagt tattgtgaga tctgattgtt taaaagtgtg   3840

tgccacctcc tcccactttc ctcctgctcc agccatgtaa gacaggcttg cctccccttc   3900

accttttgtc atgattgtaa gtgttctgag gcctccccag ccatgcttcc tgtacagcct   3960

gcagaactgt gagccaatta aacctctttt ctctatatat tacccagtct cgggtatttc   4020

tttatagcag tgcaagaata gactaataca gggttcaatt cagcaagagg atataacaaa   4080

tataaatata tatgcactca acactgcagc acccagatat ataaagcaaa tacgattaga   4140

gctaaagaga gagagtgacc ccaatacaat aatagctgga gacttcaaca ccacattttc   4200

agcactggac agatcttcca gacagaaaat aaaaaagaaa catcagactt aatctgcact   4260

gtagatcaaa tggatctaat acatacttgc agaacatttt atccaatggc tgcagaatac   4320

acattctttt ttagcacatg tatcattctc aaggatagac catatgttag gtcacaagtc   4380

ttaaaacatt aaaaaagttg aataccatca agcatcttct ctgaccacag tggaatacaa   4440

ctagaaacta ataacaagag gaatttttga aactacaaat acatgaaaat taaacaatat   4500

gctcctgaat gaccattgag tcaatgaaga aattaagaag gaaattgaac aatttc       4556


<210>  4713
<211>  143
<212>  PRT
<213>  Homosapiens

<400>  4713

Met Lys Ser Arg Leu Arg Arg Ser Gln Met Glu Met Arg Asp Leu Leu 
1               5                   10                  15      


Gly Pro Gly Val Lys Val Thr Phe Val Arg Thr Leu Trp Leu Glu Thr 
            20                  25                  30          


Leu Cys Pro Cys Pro Arg Asn Leu Trp Asn Phe Glu Leu Glu Ser Glu 
        35                  40                  45              


Asp Leu Gly Tyr Leu Ala Glu Glu Ile Ser Lys Gln Gln Ser Val Gln 
    50                  55                  60                  


Asp Val Ala Trp Leu Leu Leu Val Val Cys Ala His Ile Cys Glu Gln 
65                  70                  75                  80  


Arg His Asp Lys Lys Leu Glu Leu Ile Phe Lys Lys Glu Ala Glu Cys 
                85                  90                  95      


Lys Ser Leu Glu Asn Leu Gln Pro Gly His Val Val Glu Lys Lys Lys 
            100                 105                 110         


Thr Ile Phe Trp Arg Gly Ile Gln Ala Ser Cys Arg Lys Leu Gln Val 
        115                 120                 125             


Thr Arg Ser Lys Met Leu Ile Ala Lys Ile Val Gly Lys Thr Pro 
    130                 135                 140             


<210>  4714
<211>  4481
<212>  DNA
<213>  Homosapiens

<400>  4714
atgcgcgtaa gttctccccg cggtagactt caaatactct ttgtcctgcc cctgcttggc     60

gaaatttacc gaaattatct acctatcccg ctggagtggg agccggggga gagctggaac    120

cgcgtctctg ctgctcacct ttgtgtcctt agctccttcg catggggtcc gaccgcaaca    180

cgtgcgctgg ataaacgctt gttaactgga gctccctctt tgcccactag cagggcatta    240

gctggtgctg aagacagtgg ctgcttggcg agcctggatc tccaagtgac cccctcagca    300

actcctgatg aacaggactg aagccaatat taaagcaagt caaccaaagg ttctctggtg    360

tagacaagac agcaaaagga cagactacct tgtggaacct agcattgttc tccttctgca    420

gcactaagta acatttgttc tccgttaaga tctttgcaaa ccacacacaa gaattgctgg    480

tcatcctgcc aatagatgct gctcacagaa ccaaatttcc tgtgctgaat tgtcactcat    540

gggcttgaga gtaggagact ggagaccaag gtggctagaa tccagttggg cctgatgtct    600

ccctgttgaa agggctcctt gtggaatgaa tagcacatgg ctcctgtggt ggatctgata    660

gtggcatagc accaagtgat gcaggcctgc caggggccac agacacagaa gatgctcccg    720

gggtccccca tgtactccag acacactgca ggccacctct cccagcaggt tgccagtcat    780

gggccccatc atcatgactt ctgtccaagg tgtgctcgga aatctcttcc ttaactgtga    840

ctttctgaca ggtggaggat gtggtcagga gtgggaaaag gattcgagac gggaagaggg    900

aggggttcag gatgaagaga gataatctgt gccacagatg ctggccctgc agttagctcc    960

cacctagtcc gtgcacacac attctaatcc cctcccattc ctttacatgc tgcggccaga   1020

gaggcctttc tcaaagtgga agtctcatcc tcacttctct ggttacagtg ctgggccatg   1080

gtaacttaca aggcttagca ggaactgtct gcgcactccc ccttcctgcc cactaccttg   1140

tttccctcca gttgcgagag aaaacattga ttgagcatta actatgtgcc aggcttgtcc   1200

taagtccttt gcatgtattc actcaaacaa tcctcacaac attcctatca catctcccat   1260

ttcacagtga gggttctaaa gcacgtagtg ggtgaggaac ttgtccaggg tcacacaact   1320

aagtgggggt ggagaaacat caaatctagg tggtccaggt ggtggccaga acccatcagc   1380

acctcactac agctgcctcc agtttctcgc tctaggaaat actcttccct gtcaactcct   1440

gttgtcctct gggctcagtt gacatgtcat ctccttgagg aggacatcct gagatgctcc   1500

ccgactaggg tgggcaccca cttccacact ccaaatgcct atttgacctg tgtatcgctg   1560

catccccact gcctggcaga tagcaggccc ctaataaata tgatttgagc aaataaatat   1620

agttcttcaa aaaataggga ggacttcttg cttcaggtaa tggtaggcta ggacatttgg   1680

accaaccctc ctgcagaaaa tagccattta ttttgatgca atatatctgg ctatgactag   1740

agatttcaaa tatttggagg gctattatgt gaagaactaa acttactctt tgtgacatag   1800

aggtcagaaa ttggtcgttt ccatagagta tgagagagac agaattgtgc tcatcataag   1860

tatctttttt aaaagttaga cttaataaaa tgggctgcct tggtaggtgg tgagttctct   1920

gtcacgaaag agattcagcc acttgctctg agaaagcatg gagaatatca acattgtaag   1980

ggtcgaccac ctcatctctg aggccccctc ctcacttagg ttgccattgc aggtggaaca   2040

ctgggctgag tgtcaaagaa cctgggttcc acaagctgtg cgaccatggc tggttgtttt   2100

ggatctcatt cctaatatct gttagttaag ctgacccgtc aatactgacc cacttcacag   2160

agttatgaag ggattaaatt aggtattaca tgtaaatctg ttttgtttgc tttttgttgt   2220

tcttttttgt tttgcttttt tctttgcatt atgaaatccc aagtcaactt tttccattct   2280

tttatttttt taaaaattga catcatcatt ataaccacaa aataattttt aaaatggaaa   2340

aaaaaaactc acctgcaacc ccacaatcta atacaataat catacttttt tccctttatt   2400

ctcctttatt gtgaccaagg atgactttgg gcattgctgt gaggaactat ttcgtttaac   2460

accctactac ctgaacatga tgcgtactca gcctttcacc accccccaag tagctacaca   2520

tgatgtgata atagtattgg tggtggtttt agagagttgg agagaaaact gaagttggat   2580

ttgggtaaaa gaaaaaagag tgggaattat tttttctcca ttctaaagcc cataaagcaa   2640

tgttaattgt tcccacccct ctgctattct gtctcctcag gtactgtgtg cagaaatgtg   2700

attgagattc aagtcagggc ctctctgccc ttttccctcc agaaacaaaa ccaagataat   2760

ttatcctgaa cacggtgaaa aaaggaaggg agggaggaga aaaagtccgg gtctcacctg   2820

ggattctctg tctcctgcaa catgaaggat ttagcctggg aggaggtggt gagaactctg   2880

ggagagaaaa aagaaggaaa gaatagtttt acccatgctg aagttaattt aaaccttcac   2940

ctagagaagc aaaaaaaaaa aacccacact ttcccatttt gtgcctccct tcctagagtt   3000

ttagccaaag gtttagctaa gtaattggtt ttaccagcgc actcactcct cctatcccaa   3060

gtctgtttga ctccctcccc atcatcctcc tcacctcttt tcaggcaggg tggggatagc   3120

agcaggagga gattttggga gcctggcaac tcctgcaagg accgcaggac agcccctctg   3180

tggggatgcg tggtgcccca tctgccgccc ttctgaagaa tgcactgcct tcacttttta   3240

ctgtgttaga gtccatccag actgttctat ccaaaaaagt ttctttttcc cccacaggca   3300

atcaggaaat gattcctttc ccgactgctt ctgtctagtg cctgggaatc ttgagtcaat   3360

ccctcagtaa gtcagtgact agggaaatcc ctctctgagc ctcccagttc atgttgctta   3420

gggaacctga tattttcgtg aaacctgcct acacatgggc agcccaacag cagaacaaat   3480

ggtggtgacc aaagtgaaca aagaagtata gttgtgccag cttcgtagtt gcccatgtgg   3540

acaagtcagc aggatcagga cacgaggaag agtaaatgtg agacagtcaa tgtgacttct   3600

gcgataaaca gatttttaaa ccccgaaatt ttgcaaaatt ttggtgaaac ctgaactttc   3660

ttcgttgcat atactggcac tatctgtacc atcatacaac tgtctcacat taaagctatt   3720

tttcttgggc actgatgagt aaggttggta taagttcctc agatcaacaa aaacccattt   3780

tcctgtaagt cttacattta gtatttaagg aactaaaact taaatacatt ttgtgaaatg   3840

gttgacactt cactgataat gatttattgc ttggattaat aaattttcca aaagttgtct   3900

tatgtagaat atggtttgca accagcagaa ccattaatct atactgcaat gatatgcact   3960

atgtataatt gtttaaaagc ctctacttaa tgatgtaaaa tgctctattt aattacacat   4020

ttgggtaaac tgtatactaa catctgatgg catttttcca ctgtttgttg cttttttcaa   4080

atactttatt gtacaaagct gttcttaata tttttcaagt ttttttcttt gaattttgct   4140

aatgttttcc ttgaattatg agcactgaca gaatgtgctt agcacttttg gctattcaca   4200

cagcttttga gcatgatttg catccaatat ttacattgct agcaataata agccatctgt   4260

gagttttgtc aaaagttatt ggggattttt taaattttag aaatgcaaat tattgtttct   4320

ttgaactaac tcttatgcag ttgcaaaggc atttccagtt gttatagttt gtgtacaata   4380

tcaggtgttc cagattatga ttcattatta atatcattgc ttccttgttc cctctgaggt   4440

ccagaagatt catgtttaca atatttagaa acaatgttaa a                       4481


<210>  4715
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  4715

Met Arg Val Ser Ser Pro Arg Gly Arg Leu Gln Ile Leu Phe Val Leu 
1               5                   10                  15      


Pro Leu Leu Gly Glu Ile Tyr Arg Asn Tyr Leu Pro Ile Pro Leu Glu 
            20                  25                  30          


Trp Glu Pro Gly Glu Ser Trp Asn Arg Val Ser Ala Ala His Leu Cys 
        35                  40                  45              


Val Leu Ser Ser Phe Ala Trp Gly Pro Thr Ala Thr Arg Ala Leu Asp 
    50                  55                  60                  


Lys Arg Leu Leu Thr Gly Ala Pro Ser Leu Pro Thr Ser Arg Ala Leu 
65                  70                  75                  80  


Ala Gly Ala Glu Asp Ser Gly Cys Leu Ala Ser Leu Asp Leu Gln Val 
                85                  90                  95      


Thr Pro Ser Ala Thr Pro Asp Glu Gln Asp 
            100                 105     


<210>  4716
<211>  165
<212>  DNA
<213>  Homosapiens

<400>  4716
atgccgaagg cgcccaagca gcagctgccg gagcccgagt ggatcgggga cggagagaac     60

acgagcccat caggtgaggc tggtaggcaa ggaagacacg agaggaaggg gaagagagag    120

gagactgcgc gtgttttagg agagggtcat ggggcgcgag actga                    165


<210>  4717
<211>  54
<212>  PRT
<213>  Homosapiens

<400>  4717

Met Pro Lys Ala Pro Lys Gln Gln Leu Pro Glu Pro Glu Trp Ile Gly 
1               5                   10                  15      


Asp Gly Glu Asn Thr Ser Pro Ser Gly Glu Ala Gly Arg Gln Gly Arg 
            20                  25                  30          


His Glu Arg Lys Gly Lys Arg Glu Glu Thr Ala Arg Val Leu Gly Glu 
        35                  40                  45              


Gly His Gly Ala Arg Asp 
    50                  


<210>  4718
<211>  165
<212>  DNA
<213>  Homosapiens

<400>  4718
atgccgaagg cgcccaagca gcagctgccg gagcccgagt ggatcgggga cggagagaac     60

acgagcccat caggtgaggc tggtaggcaa ggaagacacg agaggaaggg gaagagagag    120

gagactgcgc gtgttttagg agagggtcat ggggcgcgag actga                    165


<210>  4719
<211>  54
<212>  PRT
<213>  Homosapiens

<400>  4719

Met Pro Lys Ala Pro Lys Gln Gln Leu Pro Glu Pro Glu Trp Ile Gly 
1               5                   10                  15      


Asp Gly Glu Asn Thr Ser Pro Ser Gly Glu Ala Gly Arg Gln Gly Arg 
            20                  25                  30          


His Glu Arg Lys Gly Lys Arg Glu Glu Thr Ala Arg Val Leu Gly Glu 
        35                  40                  45              


Gly His Gly Ala Arg Asp 
    50                  


<210>  4720
<211>  2841
<212>  DNA
<213>  Homosapiens

<400>  4720
tccagtctcc ggatctccct cggtccctct ctcctcctct tcctctctct ggacgcccgg     60

ctcctccgca ccccctcccc cgggggtccc gcggccttgc tccctaccct cacctcaaga    120

cgaccatggc caccatccca gactggaagc tacagctgct agcccggcgc cggcaggagg    180

aggcgtccgt tcgaggccga gagaaagcag aacgggagcg cctgtcccag atgccagcct    240

ggaaacgagg gctcctggag cgccgccggg ccaagcttgg gctgtcccct ggggagccta    300

gccctgtgct agggactgta gaggctggac ctccagaccc ggatgagtct gcggtccttc    360

tggaggccat cgggccagtg caccagaacc gattcatccg gcaggagcgg cagcagcagc    420

agcagcaaca acaacggagt gaagagctgc tagcagagag aaagcctggg cctctggagg    480

cccgggagcg gagacccagc cctggggaga tgcgggatca gagccccaag ggaagagagt    540

caagagaaga gagactaagt ccgagggaga ccagagagag gaggctgggg atagggggag    600

cccaagagtt gagcctgagg cctctggagg ctcgggactg gaggcaaagc ccaggagagg    660

tgggagacag gagctcccga ctgtcagagg catggaaatg gaggctgagt cctggagaaa    720

ctccagagcg gagtctgaga ctagcagagt ctcgagagca aagccccagg agaaaagagg    780

tggaaagtag actgagccca ggggaatctg cctaccagaa gttgggcctg acagaggccc    840

ataaatggag acctgactcc agagagtctc aggaacagag tttggtacaa ctggaggcaa    900

cagagtggag gctgaggtca ggagaagaaa gacaagacta ctcggaagaa tgtgggagaa    960

aagaagagtg gccagttcca ggggtagctc caaaagagac tgcagagctg tccgagaccc   1020

tgacaaggga ggcccaaggc aacagttccg caggagtgga ggcagcagag cagaggcctg   1080

tggaagatgg cgagaggggc atgaagccaa cagaagggtg gaaatggacc ctgaactccg   1140

ggaaggctcg agaatggaca cccagggaca tagaggctca aactcagaaa ccagaacctc   1200

cagagtcagc agagaagctt ctggaatctc ccggtgtgga ggctggagaa ggggaggctg   1260

agaaggagga ggcgggggct cagggcaggc ctctgagagc cctgcagaac tgctgctctg   1320

tgccctcccc cctcccacca gaggacgctg ggactggagg cctgagacag caggaagagg   1380

aagcagtgga gctccagccc ccaccaccag cccctctgtc tcccccaccc ccagccccaa   1440

ctgcccccca acctcctggg gatcccctca tgagccgcct gttctatggg gtgaaggcag   1500

ggccaggggt gggggccccc cgccgcagtg gacacacctt caccgtcaac ccccggcggt   1560

ctgtgccccc tgcgacccca gccaccccaa cctctccagc cacagttgat gctgcagtcc   1620

cgggggctgg gaagaagcgg tacccaactg ccgaggagat cttggttctg gggggctacc   1680

tccgtctcag ccgcagctgc cttgccaagg ggtcccccga aagacaccac aaacagctta   1740

agatctcctt cagcgagaca gccctggaga ccacgtacca atacccctcc gagagttcgg   1800

tactggagga gctgggcccg gagcctgagg tccccagtgc ccccaaccct ccagcagccc   1860

aacccgacga cgaagaggat gaggaagagc tgctgctgct gcagccagag ctccagggcg   1920

ggctgcgcac caaggccctg attgtggatg agtcctgccg gcggtgacca tcttccaaca   1980

tagggatata cctccctcct tcttataact gaagatcctg gagcccggaa gattcagggc   2040

agacagaccc tgataatgag cctggcaggg aagggcaacc aacatcttgt aacttgcttt   2100

ccccaccctg tttctggggg cagagccaat tgcccaattt ctaccctaat ccaaagtccc   2160

tggtgtgggt ggggttaaac gtgctggtgc atcctaggtc atccaagagt gagcgccaag   2220

tcctgagaag gggcacagaa ctccctggag ggtggagatg gagcacctgc cccccatggc   2280

agggtacact ctccccacag ccttcctccc caccatcccg tggggactct cgggatttaa   2340

gcactcgtct ctctgggagg cccagacccc actccattta taggcacatc tccttcattt   2400

cctaggtcac tgcccctttg tttacagctc ctgcctcctc ccttgaccac agcctggttt   2460

acaaattcca tcagctccca gccccacctg ccaaagtccc aggtttacaa gccacgctta   2520

cttgctgtgt ctgcgtggaa ttctctcctc tgtcccctcc agtctcctca ttggagtgac   2580

ctgaaggtgt ggcttcctcc actttttctc agtattactt tgccttagtt ttccccaaga   2640

gggaaggctg gaactcttaa ctctgtaccc cttgatagtt atttaattct gtttctccta   2700

gtggttcaca attgaactga attgagatgg tgtcgggtgg ctaaggagac acctcacctc   2760

tccttcccca ttgtgccgcc tttatcaatt gcctgttttg ttttgtttgt tttttaactt   2820

tccataataa aatggagttc t                                             2841


<210>  4721
<211>  613
<212>  PRT
<213>  Homosapiens

<400>  4721

Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210>  4722
<211>  3039
<212>  DNA
<213>  Homosapiens

<400>  4722
gcggtgctgg aagcggagcc gggacctttg gggcccgcgc tgagacgcgc ccggctgctg     60

ccgccgccct cctttcccct cttccctggt ttcccttctc ctctagacct gttcgctctc    120

cgcccctcct tgcctcccca acaccccctc aggtcccgtt gcctcctggt cctttcaggg    180

attcctggtc cttccttccc acactagcct ccctggggta tcgctgaggc agcctggcct    240

gcacccaggt tcccctcacc cctgccacat ttctctcttc tccctcacgc caactttcct    300

tttcgccctt ctctctcttt ctcacatcct agagacggtc tttaatacgc attaaccctg    360

tgctgccaca tctggctcct gccctcattg cctccaatcc ggactcttcc tctcacatca    420

cccccaccac ccccaacttg ggctcacaac ttctcttcac tttttccatt tccccagttc    480

tctgccttcc gtctttccct ctgtcctcat ccttagcccc tctgccctgc tttgtgtccc    540

acctctcccc ctccacttcc tctcctccca ccctcagtct cacccccggg ctgtctcact    600

ctctggagcc tctccttcct gttctctgtc cccagtgctc cctaccctca cctcaagacg    660

accatggcca ccatcccaga ctggaagcta cagctgctag cccggcgccg gcaggaggag    720

gcgtccgttc gaggccgaga gaaagcagaa cgggagcgcc tgtcccagat gccagcctgg    780

aaacgagggc tcctggagcg ccgccgggcc aagcttgggc tgtcccctgg ggagcctagc    840

cctgtgctag ggactgtaga ggctggacct ccagacccgg atgagtctgc ggtccttctg    900

gaggccatcg ggccagtgca ccagaaccga ttcatccggc aggagcggca gcagcagcag    960

cagcaacaac aacggagtga agagctgcta gcagagagaa agcctgggcc tctggaggcc   1020

cgggagcgga gacccagccc tggggagatg cgggatcaga gccccaaggg aagagagtca   1080

agagaagaga gactaagtcc gagggagacc agagagagga ggctggggat agggggagcc   1140

caagagttga gcctgaggcc tctggaggct cgggactgga ggcaaagccc aggagaggtg   1200

ggagacagga gctcccgact gtcagaggca tggaaatgga ggctgagtcc tggagaaact   1260

ccagagcgga gtctgagact agcagagtct cgagagcaaa gccccaggag aaaagaggtg   1320

gaaagtagac tgagcccagg ggaatctgcc taccagaagt tgggcctgac agaggcccat   1380

aaatggagac ctgactccag agagtctcag gaacagagtt tggtacaact ggaggcaaca   1440

gagtggaggc tgaggtcagg agaagaaaga caagactact cggaagaatg tgggagaaaa   1500

gaagagtggc cagttccagg ggtagctcca aaagagactg cagagctgtc cgagaccctg   1560

acaagggagg cccaaggcaa cagttccgca ggagtggagg cagcagagca gaggcctgtg   1620

gaagatggcg agaggggcat gaagccaaca gaagggtgga aatggaccct gaactccggg   1680

aaggctcgag aatggacacc cagggacata gaggctcaaa ctcagaaacc agaacctcca   1740

gagtcagcag agaagcttct ggaatctccc ggtgtggagg ctggagaagg ggaggctgag   1800

aaggaggagg cgggggctca gggcaggcct ctgagagccc tgcagaactg ctgctctgtg   1860

ccctcccccc tcccaccaga ggacgctggg actggaggcc tgagacagca ggaagaggaa   1920

gcagtggagc tccagccccc accaccagcc cctctgtctc ccccaccccc agccccaact   1980

gccccccaac ctcctgggga tcccctcatg agccgcctgt tctatggggt gaaggcaggg   2040

ccaggggtgg gggccccccg ccgcagtgga cacaccttca ccgtcaaccc ccggcggtct   2100

gtgccccctg cgaccccagc caccccaacc tctccagcca cagttgatgc tgcagtcccg   2160

ggggctggga agaagcggta cccaactgcc gaggagatct tggttctggg gggctacctc   2220

cgtctcagcc gcagctgcct tgccaagggg tcccccgaaa gacaccacaa acagcttaag   2280

atctccttca gcgagacagc cctggagacc acgtaccaat acccctccga gagttcggta   2340

ctggaggagc tgggcccgga gcctgaggtc cccagtgccc ccaaccctcc agcagcccaa   2400

cccgacgacg aagaggatga ggaagagctg ctgctgctgc agccagagct ccagggcggg   2460

ctgcgcacca aggccctgat tgtggatgag tcctgccggc ggtgaccatc ttccaacata   2520

gggatatacc tccctccttc ttataactga agatcctgga gcccggaaga ttcagggcag   2580

acagaccctg ataatgagcc tggcagggaa gggcaaccaa catcttgtaa cttgctttcc   2640

ccaccctgtt tctgggggca gagccaattg cccaatttct accctaatcc aaagtccctg   2700

gtttacaagc cacgcttact tgctgtgtct gcgtggaatt ctctcctctg tcccctccag   2760

tctcctcatt ggagtgacct gaaggtgtgg cttcctccac tttttctcag tattactttg   2820

ccttagtttt ccccaagagg gaaggctgga actcttaact ctgtacccct tgatagttat   2880

ttaattctgt ttctcctagt ggttcacaat tgaactgaat tgagatggtg tcgggtggct   2940

aaggagacac ctcacctctc cttccccatt gtgccgcctt tatcaattgc ctgttttgtt   3000

ttgtttgttt tttaactttc cataataaaa tggagttct                          3039


<210>  4723
<211>  613
<212>  PRT
<213>  Homosapiens

<400>  4723

Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210>  4724
<211>  4587
<212>  DNA
<213>  Homosapiens

<400>  4724
ccagagcggc cgggtcccca ttcccattcc ttcaaatccc ctttttcccg gcagccgacc     60

tgtagaccca agggagacag gttgaagcta gaaagagtcg gggcagcagc tctggtaggg    120

gagggagcat ccaaaacctc tggcttctga gcgcctctcc tgccgcccat ccacaaagcc    180

ccccacagcc tggcggctgc cctcgacccc gcaaaacaaa ggacttcaga ggctggacct    240

acagacccag atgagaaggc aaaagcgtag ggaggagcgg caggagatgg gaagggcggg    300

ccccgctcgg agcagctgcc gcttcctccc aaagtcccac gaggggcctg agtcacgggc    360

caccgccctg ggtcggcgag ctgggggaag ggatctggac acctggcgtg tccgggcggg    420

aagctggtga gggcccctgg ggacagagcg gaggaccagt ggttggggcg agaagagggc    480

agtcccgcag cgagtcccac gcggggtggg agggatctag gccccgccct ctcctcggct    540

ccgccctgcg cccccttccc tctcctcatt gtccttagac aaagcggtcg ccgcccccgc    600

ccggccccct ggtctctgtc tccgtccctc ctcctttgct gcctctttcc ctcctcctct    660

ccctccctcc tcccctccct ccagtctccg gatctccctc ggtccctctc tcctcctctt    720

cctctctctg gacgcccggc tcctccgcac cccctccccc gggggtcccg cggcctgtga    780

gttgactgag gggctcagac ttggggagtg ggtgtctcct cgcccctgtc cttgctcccg    840

tccctggccc ggaccttggc tgtctcctct ttgtgccgag attgtcagtc tgtgcggcta    900

cagcggggtg gagacggccg gctctgtcac ggcttcatga gagcggggac ggggcgcagg    960

acttgcaggc gccggggaga agagacatgg agccggccct tggcactctg gggtcgcgtg   1020

gggcagtcgg tgggggaggc aggcggtggt gacaggacag ggtgggggtg gacgccaggg   1080

ttctgggaac gcgctggcag ccctgacgcc cgggttccga aagtctcggg ggtggctatt   1140

tcccccgacc cgcctcgggg gcggagtgcg gggcagaggg gtgggggctg gggagaggcg   1200

tggcccgagc ggtgctggaa gcggagccgg gacctttggg gcccgcgctg agacgcgccc   1260

ggctgctgcc gccgccctcc tttcccctct tccctggttt cccttctcct ctagacctgt   1320

tcgctctccg cccctccttg cctccccaac accccctcag gtcccgttgc ctcctggtcc   1380

tttcagggat tcctggtcct tccttcccac actagcctcc ctggggtatc gctgaggcag   1440

cctggcctgc acccaggttc ccctcacccc tgccacattt ctctcttctc cctcacgcca   1500

actttccttt tcgcccttct ctctctttct cacatcctag agacggtctt taatacgcat   1560

taaccctgtg ctgccacatc tggctcctgc cctcattgcc tccaatccgg actcttcctc   1620

tcacatcacc cccaccaccc ccaacttggg ctcacaactt ctcttcactt tttccatttc   1680

cccagttctc tgccttccgt ctttccctct gtcctcatcc ttagcccctc tgccctgctt   1740

tgtgtcccac ctctccccct ccacttcctc tcctcccacc ctcagtctca cccccgggct   1800

gtctcactct ctggagcctc tccttcctgt tctctgtccc cagtgctccc taccctcacc   1860

tcaagacgac catggccacc atcccagact ggaagctaca gctgctagcc cggcgccggc   1920

aggaggaggc gtccgttcga ggccgagaga aagcagaacg ggagcgcctg tcccagatgc   1980

cagcctggaa acgagggctc ctggagcgcc gccgggccaa gcttgggctg tcccctgggg   2040

agcctagccc tgtgctaggg actgtagagg ctggacctcc agacccggat gagtctgcgg   2100

tccttctgga ggccatcggg ccagtgcacc agaaccgatt catccggcag gagcggcagc   2160

agcagcagca gcaacaacaa cggagtgaag agctgctagc agagagaaag cctgggcctc   2220

tggaggcccg ggagcggaga cccagccctg gggagatgcg ggatcagagc cccaagggaa   2280

gagagtcaag agaagagaga ctaagtccga gggagaccag agagaggagg ctggggatag   2340

ggggagccca agagttgagc ctgaggcctc tggaggctcg ggactggagg caaagcccag   2400

gagaggtggg agacaggagc tcccgactgt cagaggcatg gaaatggagg ctgagtcctg   2460

gagaaactcc agagcggagt ctgagactag cagagtctcg agagcaaagc cccaggagaa   2520

aagaggtgga aagtagactg agcccagggg aatctgccta ccagaagttg ggcctgacag   2580

aggcccataa atggagacct gactccagag agtctcagga acagagtttg gtacaactgg   2640

aggcaacaga gtggaggctg aggtcaggag aagaaagaca agactactcg gaagaatgtg   2700

ggagaaaaga agagtggcca gttccagggg tagctccaaa agagactgca gagctgtccg   2760

agaccctgac aagggaggcc caaggcaaca gttccgcagg agtggaggca gcagagcaga   2820

ggcctgtgga agatggcgag aggggcatga agccaacaga agggtggaaa tggaccctga   2880

actccgggaa ggctcgagaa tggacaccca gggacataga ggctcaaact cagaaaccag   2940

aacctccaga gtcagcagag aagcttctgg aatctcccgg tgtggaggct ggagaagggg   3000

aggctgagaa ggaggaggcg ggggctcagg gcaggcctct gagagccctg cagaactgct   3060

gctctgtgcc ctcccccctc ccaccagagg acgctgggac tggaggcctg agacagcagg   3120

aagaggaagc agtggagctc cagcccccac caccagcccc tctgtctccc ccacccccag   3180

ccccaactgc cccccaacct cctggggatc ccctcatgag ccgcctgttc tatggggtga   3240

aggcagggcc aggggtgggg gccccccgcc gcagtggaca caccttcacc gtcaaccccc   3300

ggcggtctgt gccccctgcg accccagcca ccccaacctc tccagccaca gttgatgctg   3360

cagtcccggg ggctgggaag aagcggtacc caactgccga ggagatcttg gttctggggg   3420

gctacctccg tctcagccgc agctgccttg ccaaggggtc ccccgaaaga caccacaaac   3480

agcttaagat ctccttcagc gagacagccc tggagaccac gtaccaatac ccctccgaga   3540

gttcggtact ggaggagctg ggcccggagc ctgaggtccc cagtgccccc aaccctccag   3600

cagcccaacc cgacgacgaa gaggatgagg aagagctgct gctgctgcag ccagagctcc   3660

agggcgggct gcgcaccaag gccctgattg tggatgagtc ctgccggcgg tgaccatctt   3720

ccaacatagg gatatacctc cctccttctt ataactgaag atcctggagc ccggaagatt   3780

cagggcagac agaccctgat aatgagcctg gcagggaagg gcaaccaaca tcttgtaact   3840

tgctttcccc accctgtttc tgggggcaga gccaattgcc caatttctac cctaatccaa   3900

agtccctggt gtgggtgggg ttaaacgtgc tggtgcatcc taggtcatcc aagagtgagc   3960

gccaagtcct gagaaggggc acagaactcc ctggagggtg gagatggagc acctgccccc   4020

catggcaggg tacactctcc ccacagcctt cctccccacc atcccgtggg gactctcggg   4080

atttaagcac tcgtctctct gggaggccca gaccccactc catttatagg cacatctcct   4140

tcatttccta ggtcactgcc cctttgttta cagctcctgc ctcctccctt gaccacagcc   4200

tggtttacaa attccatcag ctcccagccc cacctgccaa agtcccaggt ttacaagcca   4260

cgcttacttg ctgtgtctgc gtggaattct ctcctctgtc ccctccagtc tcctcattgg   4320

agtgacctga aggtgtggct tcctccactt tttctcagta ttactttgcc ttagttttcc   4380

ccaagaggga aggctggaac tcttaactct gtaccccttg atagttattt aattctgttt   4440

ctcctagtgg ttcacaattg aactgaattg agatggtgtc gggtggctaa ggagacacct   4500

cacctctcct tccccattgt gccgccttta tcaattgcct gttttgtttt gtttgttttt   4560

taactttcca taataaaatg gagttct                                       4587


<210>  4725
<211>  613
<212>  PRT
<213>  Homosapiens

<400>  4725

Met Ala Thr Ile Pro Asp Trp Lys Leu Gln Leu Leu Ala Arg Arg Arg 
1               5                   10                  15      


Gln Glu Glu Ala Ser Val Arg Gly Arg Glu Lys Ala Glu Arg Glu Arg 
            20                  25                  30          


Leu Ser Gln Met Pro Ala Trp Lys Arg Gly Leu Leu Glu Arg Arg Arg 
        35                  40                  45              


Ala Lys Leu Gly Leu Ser Pro Gly Glu Pro Ser Pro Val Leu Gly Thr 
    50                  55                  60                  


Val Glu Ala Gly Pro Pro Asp Pro Asp Glu Ser Ala Val Leu Leu Glu 
65                  70                  75                  80  


Ala Ile Gly Pro Val His Gln Asn Arg Phe Ile Arg Gln Glu Arg Gln 
                85                  90                  95      


Gln Gln Gln Gln Gln Gln Gln Arg Ser Glu Glu Leu Leu Ala Glu Arg 
            100                 105                 110         


Lys Pro Gly Pro Leu Glu Ala Arg Glu Arg Arg Pro Ser Pro Gly Glu 
        115                 120                 125             


Met Arg Asp Gln Ser Pro Lys Gly Arg Glu Ser Arg Glu Glu Arg Leu 
    130                 135                 140                 


Ser Pro Arg Glu Thr Arg Glu Arg Arg Leu Gly Ile Gly Gly Ala Gln 
145                 150                 155                 160 


Glu Leu Ser Leu Arg Pro Leu Glu Ala Arg Asp Trp Arg Gln Ser Pro 
                165                 170                 175     


Gly Glu Val Gly Asp Arg Ser Ser Arg Leu Ser Glu Ala Trp Lys Trp 
            180                 185                 190         


Arg Leu Ser Pro Gly Glu Thr Pro Glu Arg Ser Leu Arg Leu Ala Glu 
        195                 200                 205             


Ser Arg Glu Gln Ser Pro Arg Arg Lys Glu Val Glu Ser Arg Leu Ser 
    210                 215                 220                 


Pro Gly Glu Ser Ala Tyr Gln Lys Leu Gly Leu Thr Glu Ala His Lys 
225                 230                 235                 240 


Trp Arg Pro Asp Ser Arg Glu Ser Gln Glu Gln Ser Leu Val Gln Leu 
                245                 250                 255     


Glu Ala Thr Glu Trp Arg Leu Arg Ser Gly Glu Glu Arg Gln Asp Tyr 
            260                 265                 270         


Ser Glu Glu Cys Gly Arg Lys Glu Glu Trp Pro Val Pro Gly Val Ala 
        275                 280                 285             


Pro Lys Glu Thr Ala Glu Leu Ser Glu Thr Leu Thr Arg Glu Ala Gln 
    290                 295                 300                 


Gly Asn Ser Ser Ala Gly Val Glu Ala Ala Glu Gln Arg Pro Val Glu 
305                 310                 315                 320 


Asp Gly Glu Arg Gly Met Lys Pro Thr Glu Gly Trp Lys Trp Thr Leu 
                325                 330                 335     


Asn Ser Gly Lys Ala Arg Glu Trp Thr Pro Arg Asp Ile Glu Ala Gln 
            340                 345                 350         


Thr Gln Lys Pro Glu Pro Pro Glu Ser Ala Glu Lys Leu Leu Glu Ser 
        355                 360                 365             


Pro Gly Val Glu Ala Gly Glu Gly Glu Ala Glu Lys Glu Glu Ala Gly 
    370                 375                 380                 


Ala Gln Gly Arg Pro Leu Arg Ala Leu Gln Asn Cys Cys Ser Val Pro 
385                 390                 395                 400 


Ser Pro Leu Pro Pro Glu Asp Ala Gly Thr Gly Gly Leu Arg Gln Gln 
                405                 410                 415     


Glu Glu Glu Ala Val Glu Leu Gln Pro Pro Pro Pro Ala Pro Leu Ser 
            420                 425                 430         


Pro Pro Pro Pro Ala Pro Thr Ala Pro Gln Pro Pro Gly Asp Pro Leu 
        435                 440                 445             


Met Ser Arg Leu Phe Tyr Gly Val Lys Ala Gly Pro Gly Val Gly Ala 
    450                 455                 460                 


Pro Arg Arg Ser Gly His Thr Phe Thr Val Asn Pro Arg Arg Ser Val 
465                 470                 475                 480 


Pro Pro Ala Thr Pro Ala Thr Pro Thr Ser Pro Ala Thr Val Asp Ala 
                485                 490                 495     


Ala Val Pro Gly Ala Gly Lys Lys Arg Tyr Pro Thr Ala Glu Glu Ile 
            500                 505                 510         


Leu Val Leu Gly Gly Tyr Leu Arg Leu Ser Arg Ser Cys Leu Ala Lys 
        515                 520                 525             


Gly Ser Pro Glu Arg His His Lys Gln Leu Lys Ile Ser Phe Ser Glu 
    530                 535                 540                 


Thr Ala Leu Glu Thr Thr Tyr Gln Tyr Pro Ser Glu Ser Ser Val Leu 
545                 550                 555                 560 


Glu Glu Leu Gly Pro Glu Pro Glu Val Pro Ser Ala Pro Asn Pro Pro 
                565                 570                 575     


Ala Ala Gln Pro Asp Asp Glu Glu Asp Glu Glu Glu Leu Leu Leu Leu 
            580                 585                 590         


Gln Pro Glu Leu Gln Gly Gly Leu Arg Thr Lys Ala Leu Ile Val Asp 
        595                 600                 605             


Glu Ser Cys Arg Arg 
    610             


<210>  4726
<211>  486
<212>  DNA
<213>  Homosapiens

<400>  4726
atgtcttcac atctaccttt ctatgtcaca tgtgcaagat ggttgctctg ccttcagaca     60

tcacatttac attccaggca gaaaggagaa ggaaagagca aaagatgtgt tccgaacaaa    120

tccatcttaa aaacaaacaa ggggaggggt agcaggagaa aatttaaaaa gaagaagaag    180

aaaaacaaaa acaggaaagc cgttgtttcc ctaaaagccc catcaagccg acttctaccg    240

gtgactcatt acccagtcat gtggccaccc ctggattcaa ggcagtctga ggaggtgagt    300

gtttcaaaga ggcacatgga tgccacagac aaaatcaagt ttccatggtt gaaggagaag    360

aggacgatag agtttgggga ggcagcaggc tacgtctgcc acagaagata taaagatatg    420

gagccacacg agaagatggg ggaggctgcc aaaaaagtcc actgggtaca ggtgaggagc    480

aggtga                                                               486


<210>  4727
<211>  161
<212>  PRT
<213>  Homosapiens

<400>  4727

Met Ser Ser His Leu Pro Phe Tyr Val Thr Cys Ala Arg Trp Leu Leu 
1               5                   10                  15      


Cys Leu Gln Thr Ser His Leu His Ser Arg Gln Lys Gly Glu Gly Lys 
            20                  25                  30          


Ser Lys Arg Cys Val Pro Asn Lys Ser Ile Leu Lys Thr Asn Lys Gly 
        35                  40                  45              


Arg Gly Ser Arg Arg Lys Phe Lys Lys Lys Lys Lys Lys Asn Lys Asn 
    50                  55                  60                  


Arg Lys Ala Val Val Ser Leu Lys Ala Pro Ser Ser Arg Leu Leu Pro 
65                  70                  75                  80  


Val Thr His Tyr Pro Val Met Trp Pro Pro Leu Asp Ser Arg Gln Ser 
                85                  90                  95      


Glu Glu Val Ser Val Ser Lys Arg His Met Asp Ala Thr Asp Lys Ile 
            100                 105                 110         


Lys Phe Pro Trp Leu Lys Glu Lys Arg Thr Ile Glu Phe Gly Glu Ala 
        115                 120                 125             


Ala Gly Tyr Val Cys His Arg Arg Tyr Lys Asp Met Glu Pro His Glu 
    130                 135                 140                 


Lys Met Gly Glu Ala Ala Lys Lys Val His Trp Val Gln Val Arg Ser 
145                 150                 155                 160 


Arg 
    


<210>  4728
<211>  486
<212>  DNA
<213>  Homosapiens

<400>  4728
atgtcttcac atctaccttt ctatgtcaca tgtgcaagat ggttgctctg ccttcagaca     60

tcacatctac attccaggca gaaaggagaa ggaaagagca aaagatgtgt tccgaacaaa    120

tccatcttaa aaacaaacaa ggggaggggt agcaggagaa aatttaaaaa gaagaagaag    180

aaaaacaaaa acaggaaagc cgttgtttcc ctaaaagccc catcaagccg acttctaccg    240

gtgactcatt acccagtcat gtggccaccc ctggattcaa ggcagtctga ggaggtgagt    300

gtttcaaaga ggcacatgga tgccacagac aaaatcaagt ttccatggtt gaaggagaag    360

aggacgatag agtttgggga ggcagcaggc tacgtctgcc acagaagata taaagatatg    420

gagccacacg agaagatggg ggaggctgcc aaaaaagtcc actgggtaca ggtgaggagc    480

aggtga                                                               486


<210>  4729
<211>  161
<212>  PRT
<213>  Homosapiens

<400>  4729

Met Ser Ser His Leu Pro Phe Tyr Val Thr Cys Ala Arg Trp Leu Leu 
1               5                   10                  15      


Cys Leu Gln Thr Ser His Leu His Ser Arg Gln Lys Gly Glu Gly Lys 
            20                  25                  30          


Ser Lys Arg Cys Val Pro Asn Lys Ser Ile Leu Lys Thr Asn Lys Gly 
        35                  40                  45              


Arg Gly Ser Arg Arg Lys Phe Lys Lys Lys Lys Lys Lys Asn Lys Asn 
    50                  55                  60                  


Arg Lys Ala Val Val Ser Leu Lys Ala Pro Ser Ser Arg Leu Leu Pro 
65                  70                  75                  80  


Val Thr His Tyr Pro Val Met Trp Pro Pro Leu Asp Ser Arg Gln Ser 
                85                  90                  95      


Glu Glu Val Ser Val Ser Lys Arg His Met Asp Ala Thr Asp Lys Ile 
            100                 105                 110         


Lys Phe Pro Trp Leu Lys Glu Lys Arg Thr Ile Glu Phe Gly Glu Ala 
        115                 120                 125             


Ala Gly Tyr Val Cys His Arg Arg Tyr Lys Asp Met Glu Pro His Glu 
    130                 135                 140                 


Lys Met Gly Glu Ala Ala Lys Lys Val His Trp Val Gln Val Arg Ser 
145                 150                 155                 160 


Arg 
    


<210>  4730
<211>  471
<212>  DNA
<213>  Homosapiens

<400>  4730
atgggcatca gcgcgcccaa gagccagcaa ggagtcccgc cagggccgcg gcgatctcca     60

cctgcacagg ggcctcctgc agtgcccaca gcccggcgcg gccaagcctt cccgcccatc    120

ccaaggcctg ggcccaggac ccgcagcgtc tcccacttcc cggaggccgc cccggcgcgc    180

gctcaccagg aggccccgcc gctatcccag ggcgccccgc ggcggcaggg actgaggaat    240

ccaccaaacc cgaccctgga acgtggccct ggagccgcgc ggcgcatggg ggcggggccc    300

cggccggcgc atgcgcagca gctggctttg gccccaccct ctccctaccg gtccaaaggc    360

tgtagaccag aggagcgagt ccgccgcgaa ggcaaacccc acggggaggc gcccgggacc    420

gcactgctag ctatcataac tttattaaac aagaaaagcc ctgacgcgta a             471


<210>  4731
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  4731

Met Gly Ile Ser Ala Pro Lys Ser Gln Gln Gly Val Pro Pro Gly Pro 
1               5                   10                  15      


Arg Arg Ser Pro Pro Ala Gln Gly Pro Pro Ala Val Pro Thr Ala Arg 
            20                  25                  30          


Arg Gly Gln Ala Phe Pro Pro Ile Pro Arg Pro Gly Pro Arg Thr Arg 
        35                  40                  45              


Ser Val Ser His Phe Pro Glu Ala Ala Pro Ala Arg Ala His Gln Glu 
    50                  55                  60                  


Ala Pro Pro Leu Ser Gln Gly Ala Pro Arg Arg Gln Gly Leu Arg Asn 
65                  70                  75                  80  


Pro Pro Asn Pro Thr Leu Glu Arg Gly Pro Gly Ala Ala Arg Arg Met 
                85                  90                  95      


Gly Ala Gly Pro Arg Pro Ala His Ala Gln Gln Leu Ala Leu Ala Pro 
            100                 105                 110         


Pro Ser Pro Tyr Arg Ser Lys Gly Cys Arg Pro Glu Glu Arg Val Arg 
        115                 120                 125             


Arg Glu Gly Lys Pro His Gly Glu Ala Pro Gly Thr Ala Leu Leu Ala 
    130                 135                 140                 


Ile Ile Thr Leu Leu Asn Lys Lys Ser Pro Asp Ala 
145                 150                 155     


<210>  4732
<211>  471
<212>  DNA
<213>  Homosapiens

<400>  4732
atgggcatca gcgcgcccaa gagccagcaa ggagtcccgc cagggccgcg gcgatctcca     60

cctgcacagg ggcctcctgc agtgcccaca gcccggcgcg gccaggcctt cccgcccatc    120

ccaaggcctg ggcccaggac ccgcagcgtc tcccacttcc cggaggccgc cccggcgcgc    180

gctcaccagg aggccccgcc gctatcccag ggcgccccgc ggcggcaggg actgaggaat    240

ccaccaaacc cgaccctgga acgtggccct ggagccgcgc ggcgcatggg ggcggggccc    300

cggccggcgc atgcgcagca gctggctttg gccccaccct ctccctaccg gtccaaaggc    360

tgtagaccag aggagcgagt ccgccgcgaa ggcaaacccc acggggaggc gcccgggacc    420

gcactgctag ctatcataac tttattaaac aagaaaagcc ctgacgcgta a             471


<210>  4733
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  4733

Met Gly Ile Ser Ala Pro Lys Ser Gln Gln Gly Val Pro Pro Gly Pro 
1               5                   10                  15      


Arg Arg Ser Pro Pro Ala Gln Gly Pro Pro Ala Val Pro Thr Ala Arg 
            20                  25                  30          


Arg Gly Gln Ala Phe Pro Pro Ile Pro Arg Pro Gly Pro Arg Thr Arg 
        35                  40                  45              


Ser Val Ser His Phe Pro Glu Ala Ala Pro Ala Arg Ala His Gln Glu 
    50                  55                  60                  


Ala Pro Pro Leu Ser Gln Gly Ala Pro Arg Arg Gln Gly Leu Arg Asn 
65                  70                  75                  80  


Pro Pro Asn Pro Thr Leu Glu Arg Gly Pro Gly Ala Ala Arg Arg Met 
                85                  90                  95      


Gly Ala Gly Pro Arg Pro Ala His Ala Gln Gln Leu Ala Leu Ala Pro 
            100                 105                 110         


Pro Ser Pro Tyr Arg Ser Lys Gly Cys Arg Pro Glu Glu Arg Val Arg 
        115                 120                 125             


Arg Glu Gly Lys Pro His Gly Glu Ala Pro Gly Thr Ala Leu Leu Ala 
    130                 135                 140                 


Ile Ile Thr Leu Leu Asn Lys Lys Ser Pro Asp Ala 
145                 150                 155     


<210>  4734
<211>  1218
<212>  DNA
<213>  Homosapiens

<400>  4734
atgtctgtgt cagccacagc ctccagcaca gcctccagca cagcctctga gatcaccatg     60

agctctgcag ccatcccagt ctcctccaca gcttatgaga ccatcaggtt ctccactgca    120

gtgtctgagc cagtgacagc ctctatcctg gcccttgagt ccaccctggc cttcaccacg    180

gtctctaaca ccaccacatc ttccacagta acacctgtgc ccaccacagc ttccacctca    240

ggctctaaga acacaacagc ctgtgaggcc accatgtctg aaactaccat tgctgccatc    300

acagcctccg aggacaccac agtctccact caaacctctg tgatagctgc agagtctgtg    360

ccccacacag ccaccaaaac acctactgac accaccacag catctgtgtc cgccacagtc    420

cccaagaaca acacaccctc tgtgataaca tctacacctt ccacagctcc caacacagcc    480

tctaaaacca tgaccacagc ttccaagacc gccacgacct ctacgataac atctctgccc    540

accacagtct tcaccacaac ctctaaaatc accgcaggct ctgagatccc cacagcctcc    600

accacagact ctgcgaccac tgcaatctcc acaaaagcct ctgggacaac tgtagagtct    660

gcgccctcta cagcccctcc aacacctgct gagaccacca cagcatctgt gcccaccaca    720

acctctacca caggctctga gaacaccgga caccacacag tatcatctgt gcccaccaca    780

gtcttcgcta cagcctctga aagcagcaca ggctctgaga ccaccagagc ttccacctct    840

gccactgaag tgactacagc catgaccaca gccatgacca caggttctga gactgctgtg    900

gtctccacca aagctcctgt gacaaccaca cagtctgggt tctccacagc caccgtaatg    960

cctgctaaga ccactacagc gtctgtgtcc accacagcct ccaccacact ctatcagaat   1020

actatagact ccgtgaccaa gtctgtgccc accatggact ctaccatagc ctccaagagc   1080

accactctct ccaagatagt atctgtgcct actgcagtct ttatcaaagc gcctgaaacc   1140

accacaggct ctgagatcac tctggcttcc atcataacct caggaaccac tgcagtctgt   1200

gactacattg gcctctag                                                 1218


<210>  4735
<211>  405
<212>  PRT
<213>  Homosapiens

<400>  4735

Met Ser Val Ser Ala Thr Ala Ser Ser Thr Ala Ser Ser Thr Ala Ser 
1               5                   10                  15      


Glu Ile Thr Met Ser Ser Ala Ala Ile Pro Val Ser Ser Thr Ala Tyr 
            20                  25                  30          


Glu Thr Ile Arg Phe Ser Thr Ala Val Ser Glu Pro Val Thr Ala Ser 
        35                  40                  45              


Ile Leu Ala Leu Glu Ser Thr Leu Ala Phe Thr Thr Val Ser Asn Thr 
    50                  55                  60                  


Thr Thr Ser Ser Thr Val Thr Pro Val Pro Thr Thr Ala Ser Thr Ser 
65                  70                  75                  80  


Gly Ser Lys Asn Thr Thr Ala Cys Glu Ala Thr Met Ser Glu Thr Thr 
                85                  90                  95      


Ile Ala Ala Ile Thr Ala Ser Glu Asp Thr Thr Val Ser Thr Gln Thr 
            100                 105                 110         


Ser Val Ile Ala Ala Glu Ser Val Pro His Thr Ala Thr Lys Thr Pro 
        115                 120                 125             


Thr Asp Thr Thr Thr Ala Ser Val Ser Ala Thr Val Pro Lys Asn Asn 
    130                 135                 140                 


Thr Pro Ser Val Ile Thr Ser Thr Pro Ser Thr Ala Pro Asn Thr Ala 
145                 150                 155                 160 


Ser Lys Thr Met Thr Thr Ala Ser Lys Thr Ala Thr Thr Ser Thr Ile 
                165                 170                 175     


Thr Ser Leu Pro Thr Thr Val Phe Thr Thr Thr Ser Lys Ile Thr Ala 
            180                 185                 190         


Gly Ser Glu Ile Pro Thr Ala Ser Thr Thr Asp Ser Ala Thr Thr Ala 
        195                 200                 205             


Ile Ser Thr Lys Ala Ser Gly Thr Thr Val Glu Ser Ala Pro Ser Thr 
    210                 215                 220                 


Ala Pro Pro Thr Pro Ala Glu Thr Thr Thr Ala Ser Val Pro Thr Thr 
225                 230                 235                 240 


Thr Ser Thr Thr Gly Ser Glu Asn Thr Gly His His Thr Val Ser Ser 
                245                 250                 255     


Val Pro Thr Thr Val Phe Ala Thr Ala Ser Glu Ser Ser Thr Gly Ser 
            260                 265                 270         


Glu Thr Thr Arg Ala Ser Thr Ser Ala Thr Glu Val Thr Thr Ala Met 
        275                 280                 285             


Thr Thr Ala Met Thr Thr Gly Ser Glu Thr Ala Val Val Ser Thr Lys 
    290                 295                 300                 


Ala Pro Val Thr Thr Thr Gln Ser Gly Phe Ser Thr Ala Thr Val Met 
305                 310                 315                 320 


Pro Ala Lys Thr Thr Thr Ala Ser Val Ser Thr Thr Ala Ser Thr Thr 
                325                 330                 335     


Leu Tyr Gln Asn Thr Ile Asp Ser Val Thr Lys Ser Val Pro Thr Met 
            340                 345                 350         


Asp Ser Thr Ile Ala Ser Lys Ser Thr Thr Leu Ser Lys Ile Val Ser 
        355                 360                 365             


Val Pro Thr Ala Val Phe Ile Lys Ala Pro Glu Thr Thr Thr Gly Ser 
    370                 375                 380                 


Glu Ile Thr Leu Ala Ser Ile Ile Thr Ser Gly Thr Thr Ala Val Cys 
385                 390                 395                 400 


Asp Tyr Ile Gly Leu 
                405 


<210>  4736
<211>  898
<212>  DNA
<213>  Homosapiens

<400>  4736
atggcagtct tattcctcct cctgttccta tgtggaactc cccaggctgc agacaacatg     60

caggccatct atgtggcctt gggggaggca gtagagctgc catgtccctc accacctact    120

ctacatgggg acgaacacct gtcatggttc tgcagccctg cagcaggctc cttcaccacc    180

ctggtagccc aagtccaagt gggcaggcca gccccagacc ctggaaaacc aggaagggaa    240

tccaggctca gactgctggg gaactattct ttgtggttgg agggatccaa agaggaagat    300

gccgggcggt actggtgcgc tgtgctaggt cagcaccaca actaccagaa ctggagggtg    360

tacgacgtct tggtgctcaa aggatcccag ttatctgcaa gggctgcaga tggatccccc    420

tgcaatgtcc tcctgtgctc tgtggtcccc agcagacgca tggactctgt gacctggcag    480

gaagggaagg gtcccgtgag gggccgtgtt cagtccttct ggggcagtga ggctgccctg    540

ctcttggtgt gtcctgggga ggggctttct gagcccagga gccgaagacc aagaatcatc    600

cgctgcctca tgactcacaa caaaggggtc agctttagcc tggcagcctc catcgatgct    660

tctcctgccc tctgtgcccc ttccacgggc tgggacatgc cttggattct gatgctgctg    720

ctcacaatgg gccagggagt tgtcatcctg gccctcagca tcgtgctctg gaggcagagg    780

gtccgtgggg ctccaggcag agatgcctcg attcctcagt tcaaacccga aatccaggtc    840

tatgagaaca tccatttggc ccgtcttggc ccacctgccc acaagcccag gtgatttt      898


<210>  4737
<211>  297
<212>  PRT
<213>  Homosapiens

<400>  4737

Met Ala Val Leu Phe Leu Leu Leu Phe Leu Cys Gly Thr Pro Gln Ala 
1               5                   10                  15      


Ala Asp Asn Met Gln Ala Ile Tyr Val Ala Leu Gly Glu Ala Val Glu 
            20                  25                  30          


Leu Pro Cys Pro Ser Pro Pro Thr Leu His Gly Asp Glu His Leu Ser 
        35                  40                  45              


Trp Phe Cys Ser Pro Ala Ala Gly Ser Phe Thr Thr Leu Val Ala Gln 
    50                  55                  60                  


Val Gln Val Gly Arg Pro Ala Pro Asp Pro Gly Lys Pro Gly Arg Glu 
65                  70                  75                  80  


Ser Arg Leu Arg Leu Leu Gly Asn Tyr Ser Leu Trp Leu Glu Gly Ser 
                85                  90                  95      


Lys Glu Glu Asp Ala Gly Arg Tyr Trp Cys Ala Val Leu Gly Gln His 
            100                 105                 110         


His Asn Tyr Gln Asn Trp Arg Val Tyr Asp Val Leu Val Leu Lys Gly 
        115                 120                 125             


Ser Gln Leu Ser Ala Arg Ala Ala Asp Gly Ser Pro Cys Asn Val Leu 
    130                 135                 140                 


Leu Cys Ser Val Val Pro Ser Arg Arg Met Asp Ser Val Thr Trp Gln 
145                 150                 155                 160 


Glu Gly Lys Gly Pro Val Arg Gly Arg Val Gln Ser Phe Trp Gly Ser 
                165                 170                 175     


Glu Ala Ala Leu Leu Leu Val Cys Pro Gly Glu Gly Leu Ser Glu Pro 
            180                 185                 190         


Arg Ser Arg Arg Pro Arg Ile Ile Arg Cys Leu Met Thr His Asn Lys 
        195                 200                 205             


Gly Val Ser Phe Ser Leu Ala Ala Ser Ile Asp Ala Ser Pro Ala Leu 
    210                 215                 220                 


Cys Ala Pro Ser Thr Gly Trp Asp Met Pro Trp Ile Leu Met Leu Leu 
225                 230                 235                 240 


Leu Thr Met Gly Gln Gly Val Val Ile Leu Ala Leu Ser Ile Val Leu 
                245                 250                 255     


Trp Arg Gln Arg Val Arg Gly Ala Pro Gly Arg Asp Ala Ser Ile Pro 
            260                 265                 270         


Gln Phe Lys Pro Glu Ile Gln Val Tyr Glu Asn Ile His Leu Ala Arg 
        275                 280                 285             


Leu Gly Pro Pro Ala His Lys Pro Arg 
    290                 295         


<210>  4738
<211>  5426
<212>  DNA
<213>  Homosapiens

<400>  4738
agaaggtagc agacagacag acggatctaa cctctcttgg atcctccagc catgaggctg     60

ctctgggggc tgatctgggc atccagcttc ttcaccttat ctctgcagaa gcccaggttg    120

ctcttgttct ctccttctgt ggttcatctg ggggtccccc tatcggtggg ggtgcagctc    180

caggatgtgc cccgaggaca ggtagtgaaa ggatcagtgt tcctgagaaa cccatctcgt    240

aataatgtcc cctgctcccc aaaggtggac ttcaccctta gctcagaaag agacttcgca    300

ctcctcagtc tccaggtgcc cttgaaagat gcgaagagct gtggcctcca tcaactcctc    360

agaggccctg aggtccagct ggtggcccat tcgccatggc taaaggactc tctgtccaga    420

acgacaaaca tccagggtat caacctgctc ttctcctctc gccgggggca cctctttttg    480

cagacggacc agcccattta caaccctggc cagcgggttc ggtaccgggt ctttgctctg    540

gatcagaaga tgcgcccgag cactgacacc atcacagtca tggtggagaa ctctcacggc    600

ctccgcgtgc ggaagaagga ggtgtacatg ccctcgtcca tcttccagga tgactttgtg    660

atcccagaca tctcagagcc agggacctgg aagatctcag cccgattctc agatggcctg    720

gaatccaaca gcagcaccca gtttgaggtg aagaaatatg tccttcccaa ctttgaggtg    780

aagatcaccc ctggaaagcc ctacatcctg acggtgccag gccatcttga tgaaatgcag    840

ttagacatcc aggccaggta catctatggg aagccagtgc agggggtggc atatgtgcgc    900

tttgggctcc tagatgagga tggtaagaag actttctttc gggggctgga gagtcagacc    960

aagctggtga atggacagag ccacatttcc ctctcaaagg cagagttcca ggacgccctg   1020

gagaagctga atatgggcat tactgacctc caggggctgc gcctctacgt tgctgcagcc   1080

atcattgagt ctccaggtgg ggagatggag gaggcagagc tcacatcctg gtattttgtg   1140

tcatctccct tctccttgga tcttagcaag accaagcgac accttgtgcc tggggccccc   1200

ttcctgctgc aggccttggt ccgtgagatg tcaggctccc cagcttctgg cattcctgtc   1260

aaagtttctg ccacggtgtc ttctcctggg tctgttcctg aagtccagga cattcagcaa   1320

aacacagacg ggagcggcca agtcagcatt ccaataatta tccctcagac catctcagag   1380

ctgcagctct cagtatctgc aggctcccca catccagcga tagccaggct cactgtggca   1440

gccccacctt caggaggccc cgggtttctg tctattgagc ggccggattc tcgacctcct   1500

cgtgttgggg acactctgaa cctgaacttg cgagccgtgg gcagtggggc caccttttct   1560

cattactact acatgatcct atcccgaggg cagatcgtgt tcatgaatcg agagcccaag   1620

aggaccctga cctcggtctc ggtgtttgtg gaccatcacc tggcaccctc cttctacttt   1680

gtggccttct actaccatgg agaccaccca gtggccaact ccctgcgagt ggatgtccag   1740

gctggggcct gcgagggcaa gctggagctc agcgtggacg gtgccaagca gtaccggaac   1800

ggggagtccg tgaagctcca cttagaaacc gactccctag ccctggtggc gctgggagcc   1860

ttggacacag ctctgtatgc tgcaggcagc aagtcccaca agcccctcaa catgggcaag   1920

gtctttgaag ctatgaacag ctatgacctc ggctgtggtc ctgggggtgg ggacagtgcc   1980

cttcaggtgt tccaggcagc gggcctggcc ttttctgatg gagaccagtg gaccttatcc   2040

agaaagagac taagctgtcc caaggagaag acaacccgga aaaagagaaa cgtgaacttc   2100

caaaaggcga ttaatgagaa attgggtcag tatgcttccc cgacagccaa gcgctgctgc   2160

caggatgggg tgacacgtct gcccatgatg cgttcctgcg agcagcgggc agcccgcgtg   2220

cagcagccgg actgccggga gcccttcctg tcctgctgcc aatttgctga gagtctgcgc   2280

aagaagagca gggacaaggg ccaggcgggc ctccaacgag ccctggagat cctgcaggag   2340

gaggacctga ttgatgagga tgacattccc gtgcgcagct tcttcccaga gaactggctc   2400

tggagagtgg aaacagtgga ccgctttcaa atattgacac tgtggctccc cgactctctg   2460

accacgtggg agatccatgg cctgagcctg tccaaaacca aaggcctatg tgtggccacc   2520

ccagtccagc tccgggtgtt ccgcgagttc cacctgcacc tccgcctgcc catgtctgtc   2580

cgccgctttg agcagctgga gctgcggcct gtcctctata actacctgga taaaaacctg   2640

actgtgagcg tccacgtgtc cccagtggag gggctgtgcc tggctggggg cggagggctg   2700

gcccagcagg tgctggtgcc tgcgggctct gcccggcctg ttgccttctc tgtggtgccc   2760

acggcagccg ccgctgtgtc tctgaaggtg gtggctcgag ggtccttcga attccctgtg   2820

ggagatgcgg tgtccaaggt tctgcagatt gagaaggaag gggccatcca tagagaggag   2880

ctggtctatg aactcaaccc cttggaccac cgaggccgga ccttggaaat acctggcaac   2940

tctgatccca atatgatccc tgatggggac tttaacagct acgtcagggt tacagcctca   3000

gatccattgg acactttagg ctctgagggg gccttgtcac caggaggcgt ggcctccctc   3060

ttgaggcttc ctcgaggctg tggggagcaa accatgatct acttggctcc gacactggct   3120

gcttcccgct acctggacaa gacagagcag tggagcacac tgcctcccga gaccaaggac   3180

cacgccgtgg atctgatcca gaaaggctac atgcggatcc agcagtttcg gaaggcggat   3240

ggttcctatg cggcttggtt gtcacgggac agcagcacct ggctcacagc ctttgtgttg   3300

aaggtcctga gtttggccca ggagcaggta ggaggctcgc ctgagaaact gcaggagaca   3360

tctaactggc ttctgtccca gcagcaggct gacggctcgt tccaggaccc ctgtccagtg   3420

ttagacagga gcatgcaggg gggtttggtg ggcaatgatg agactgtggc actcacagcc   3480

tttgtgacca tcgcccttca tcatgggctg gccgtcttcc aggatgaggg tgcagagcca   3540

ttgaagcaga gagtggaagc ctccatctca aaggcaaact catttttggg ggagaaagca   3600

agtgctgggc tcctgggtgc ccacgcagct gccatcacgg cctatgccct gacactgacc   3660

aaggcgcctg tggacctgct cggtgttgcc cacaacaacc tcatggcaat ggcccaggag   3720

actggagata acctgtactg gggctcagtc actggttctc agagcaatgc cgtgtcgccc   3780

accccggctc ctcgcaaccc atccgacccc atgccccagg ccccagccct gtggattgaa   3840

accacagcct acgccctgct gcacctcctg cttcacgagg gcaaagcaga gatggcagac   3900

caggcttcgg cctggctcac ccgtcagggc agcttccaag ggggattccg cagtacccaa   3960

gacacggtga ttgccctgga tgccctgtct gcctactgga ttgcctccca caccactgag   4020

gagaggggtc tcaatgtgac tctcagctcc acaggccgga atgggttcaa gtcccacgcg   4080

ctgcagctga acaaccgcca gattcgcggc ctggaggagg agctgcagtt ttccttgggc   4140

agcaagatca atgtgaaggt gggaggaaac agcaaaggaa ccctgaaggt ccttcgtacc   4200

tacaatgtcc tggacatgaa gaacacgacc tgccaggacc tacagataga agtgacagtc   4260

aaaggccacg tcgagtacac gatggaagca aacgaggact atgaggacta tgagtacgat   4320

gagcttccag ccaaggatga cccagatgcc cctctgcagc ccgtgacacc cctgcagctg   4380

tttgagggtc ggaggaaccg ccgcaggagg gaggcgccca aggtggtgga ggagcaggag   4440

tccagggtgc actacaccgt gtgcatctgg cggaacggca aggtggggct gtctggcatg   4500

gccatcgcgg acgtcaccct cctgagtgga ttccacgccc tgcgtgctga cctggagaag   4560

ctgacctccc tctctgaccg ttacgtgagt cactttgaga ccgaggggcc ccacgtcctg   4620

ctgtattttg actcggtccc cacctcccgg gagtgcgtgg gctttgaggc tgtgcaggaa   4680

gtgccggtgg ggctggtgca gccggccagc gcaaccctgt acgactacta caaccccgag   4740

cgcagatgtt ctgtgtttta cggggcacca agtaagagca gactcttggc caccttgtgt   4800

tctgctgaag tctgccagtg tgctgagggg aagtgccctc gccagcgtcg cgccctggag   4860

cggggtctgc aggacgagga tggctacagg atgaagtttg cctgctacta cccccgtgtg   4920

gagtacggct tccaggttaa ggttctccga gaagacagca gagctgcttt ccgcctcttt   4980

gagaccaaga tcacccaagt cctgcacttc accaaggatg tcaaggccgc tgctaatcag   5040

atgcgcaact tcctggttcg agcctcctgc cgccttcgct tggaacctgg gaaagaatat   5100

ttgatcatgg gtctggatgg ggccacctat gacctcgagg gacaccccca gtacctgctg   5160

gactcgaata gctggatcga ggagatgccc tctgaacgcc tgtgccggag cacccgccag   5220

cgggcagcct gtgcccagct caacgacttc ctccaggagt atggcactca ggggtgccag   5280

gtgtgagggc tgccctccca cctccgctgg gaggaacctg aacctgggaa ccatgaagct   5340

ggaagcactg ctgtgtccgc tttcatgaac acagcctggg accagggcat attaaaggct   5400

tttggcagca aagtgtcagt gttggc                                        5426


<210>  4739
<211>  1744
<212>  PRT
<213>  Homosapiens

<400>  4739

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Asp Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Pro  Cys Pro Val Leu Asp  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Asn Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Val Asp Leu Leu  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ser Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210>  4740
<211>  336
<212>  DNA
<213>  Homosapiens

<400>  4740
atggatcaag gaattatagc agcttttaag gtttactatc tgaagagggc ctttgcccat     60

gttattatgg taactcagga agacactgag aagacagtga tgcaattctg gaaggataac    120

aacagctatg gctacatcaa gaaccttgct tgggatgggg atgatgtcac cgaggagtgt    180

gtgaatggca tctggaagaa gacactcagg aggtttgtct gtgagttcaa agggtttgcc    240

aaggatgagg agattgcaaa aatctacaag gctttggttg agatggcaaa caactttaaa    300

ctgagtacgg atgaggatgg cattaggagc tcctag                              336


<210>  4741
<211>  111
<212>  PRT
<213>  Homosapiens

<400>  4741

Met Asp Gln Gly Ile Ile Ala Ala Phe Lys Val Tyr Tyr Leu Lys Arg 
1               5                   10                  15      


Ala Phe Ala His Val Ile Met Val Thr Gln Glu Asp Thr Glu Lys Thr 
            20                  25                  30          


Val Met Gln Phe Trp Lys Asp Asn Asn Ser Tyr Gly Tyr Ile Lys Asn 
        35                  40                  45              


Leu Ala Trp Asp Gly Asp Asp Val Thr Glu Glu Cys Val Asn Gly Ile 
    50                  55                  60                  


Trp Lys Lys Thr Leu Arg Arg Phe Val Cys Glu Phe Lys Gly Phe Ala 
65                  70                  75                  80  


Lys Asp Glu Glu Ile Ala Lys Ile Tyr Lys Ala Leu Val Glu Met Ala 
                85                  90                  95      


Asn Asn Phe Lys Leu Ser Thr Asp Glu Asp Gly Ile Arg Ser Ser 
            100                 105                 110     


<210>  4742
<211>  336
<212>  DNA
<213>  Homosapiens

<400>  4742
atggatcaag gaattatagc agcttttaag gtttactatc tgaagagggc ctttgcccat     60

gttattatgg taactcagga agacactgag aagacagtga tgcaattctg gaaggataac    120

aacagctatg gctacatcaa gaaccttgct tgggatgggg atgatgtcac cgaggagtgt    180

gtgaatggca tctggaagaa gacactcagg aggtttgtct gtgagttcaa agggtttgcc    240

aaggatgagg agattgcaaa aatctacaag gctttggttg agatggcaaa caactttaaa    300

ctgagtacgg atgaggatgg cattaggagc tcctag                              336


<210>  4743
<211>  111
<212>  PRT
<213>  Homosapiens

<400>  4743

Met Asp Gln Gly Ile Ile Ala Ala Phe Lys Val Tyr Tyr Leu Lys Arg 
1               5                   10                  15      


Ala Phe Ala His Val Ile Met Val Thr Gln Glu Asp Thr Glu Lys Thr 
            20                  25                  30          


Val Met Gln Phe Trp Lys Asp Asn Asn Ser Tyr Gly Tyr Ile Lys Asn 
        35                  40                  45              


Leu Ala Trp Asp Gly Asp Asp Val Thr Glu Glu Cys Val Asn Gly Ile 
    50                  55                  60                  


Trp Lys Lys Thr Leu Arg Arg Phe Val Cys Glu Phe Lys Gly Phe Ala 
65                  70                  75                  80  


Lys Asp Glu Glu Ile Ala Lys Ile Tyr Lys Ala Leu Val Glu Met Ala 
                85                  90                  95      


Asn Asn Phe Lys Leu Ser Thr Asp Glu Asp Gly Ile Arg Ser Ser 
            100                 105                 110     


<210>  4744
<211>  198
<212>  DNA
<213>  Homosapiens

<400>  4744
atgcacacct ctcaaacaca ttgtcctgtg cacgggatgc tgacagccag cattgtgtcc     60

atcgctctta ttaggaagga ggactggatt ttccagatcc ttgtggtcct ggaaatgact    120

tccagtgtgc agatgtctac accagtcatg tggagcactt cagcctccag agcctgtcct    180

cacagtggag gggtgtaa                                                  198


<210>  4745
<211>  65
<212>  PRT
<213>  Homosapiens

<400>  4745

Met His Thr Ser Gln Thr His Cys Pro Val His Gly Met Leu Thr Ala 
1               5                   10                  15      


Ser Ile Val Ser Ile Ala Leu Ile Arg Lys Glu Asp Trp Ile Phe Gln 
            20                  25                  30          


Ile Leu Val Val Leu Glu Met Thr Ser Ser Val Gln Met Ser Thr Pro 
        35                  40                  45              


Val Met Trp Ser Thr Ser Ala Ser Arg Ala Cys Pro His Ser Gly Gly 
    50                  55                  60                  


Val 
65  


<210>  4746
<211>  518
<212>  DNA
<213>  Homosapiens

<400>  4746
atggcagagg aaggtgatgt ggacgaggcg gatgtgttcc tggcatttgc ccagggtccc     60

tcccctccca ggggtcccgt gcgacgtgcc ttggacaagg ctttctttat cttcctggcc    120

ctcttcctga cactgctgat gctggaggct gcttataagc tgctaaggag gaggagctgg    180

aattgtgacc acctttccta taaacatctt ctttccccac caaggagctc acctctggac    240

ccagccttgc ctccacgagt ccctccagcc tccctaaaca caacgagcag ccctcgcagc    300

ggcaatttgc acaaactctc ctccaagccc caccccatca tcgcccatcc gcagacccta    360

ggcctcccac gacaaagcac ggccacctgg tcagcacaga cggcccttcg aggaccccct    420

ctggagaaga accattcagg tcccaacggt ctggctggtc attagttctg tggtgaagct    480

tgaaaagcaa atcagcaaca atagtaataa caataaca                            518


<210>  4747
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  4747

Met Ala Glu Glu Gly Asp Val Asp Glu Ala Asp Val Phe Leu Ala Phe 
1               5                   10                  15      


Ala Gln Gly Pro Ser Pro Pro Arg Gly Pro Val Arg Arg Ala Leu Asp 
            20                  25                  30          


Lys Ala Phe Phe Ile Phe Leu Ala Leu Phe Leu Thr Leu Leu Met Leu 
        35                  40                  45              


Glu Ala Ala Tyr Lys Leu Leu Arg Arg Arg Ser Trp Asn Cys Asp His 
    50                  55                  60                  


Leu Ser Tyr Lys His Leu Leu Ser Pro Pro Arg Ser Ser Pro Leu Asp 
65                  70                  75                  80  


Pro Ala Leu Pro Pro Arg Val Pro Pro Ala Ser Leu Asn Thr Thr Ser 
                85                  90                  95      


Ser Pro Arg Ser Gly Asn Leu His Lys Leu Ser Ser Lys Pro His Pro 
            100                 105                 110         


Ile Ile Ala His Pro Gln Thr Leu Gly Leu Pro Arg Gln Ser Thr Ala 
        115                 120                 125             


Thr Trp Ser Ala Gln Thr Ala Leu Arg Gly Pro Pro Leu Glu Lys Asn 
    130                 135                 140                 


His Ser Gly Pro Asn Gly Leu Ala Gly His 
145                 150                 


<210>  4748
<211>  1385
<212>  DNA
<213>  Homosapiens

<400>  4748
cgggggcggc cgagggggaa gagtgtgtgt ctgcgggaga aagaggagaa tcacccaagc     60

ggcctcagaa gtcccaggga gtggaggccc ctgccatgga gccgtgtggt gtatgtgtgg    120

taacaccatg tctgtgcccc tgctcaacga tgctgccacc gtgtctggag ctgagcggga    180

aacggccgtg gttatttttt tacatggact tggagacaca gggcacagct gggctgacgc    240

cctctccacc attcggctcc ctcacgtcaa gtacatctgt tcccatgagc ctaggatccc    300

tgtgaccctc aacatgaaga tggtgatgcc ctcctggttt gacctgatgg ggctgagtcc    360

agatgcccca gaggacgagg ctggcatcaa gaaggcagca gagaacatca aggccttgat    420

tgagcatgaa atgaagaacg ggatccctgc caatcaaatc atcctgggag gcttttcaca    480

gggccgggcc ctgtccctct acatggccct cacctgcccc caccctctgg ctggcatcct    540

ggctttgagc tgctggccgc ctctgcaccg ggccttcccc caggcagcta atggcagtgc    600

caaggacctg gccatcctcc agtgccatgg ggagctggac cccatggtgc ccgtacggtt    660

tggggccctg atggctgaga agctccggtc tgttgtcaca cctgccaggg tccagttcca    720

gacatacctg ggtgtcatgc acagctcctg tcctcaggag atggcagctg tgaaggaatt    780

tcttgagaag ctgctgcctc ctgtctaact agtcgctggc cccagtgcag taccccagct    840

catgggggac tcagcaagta agcatggcac catcttgggt ctgagctggt cgagcccctg    900

tccccaccct tcctgacctg tccttttccc acaggcctct aggggcaggt ggcaaggcct    960

ggctgggcct tccttcctgg cctcagccac ctgcctccac tcagctgctt ctcagtcatg   1020

aacgtggcca tggccccggg ggtccccttg ctgctgtggg ctccctgtcc ctgggcagga   1080

gtgctggtga ggaggtggag ccttttgagg ggggccttcc ctcagctgtt tccccacact   1140

ggggggctgg gccctgcctc cccgttaccc tccttccctg caggcctgga gcctgtaggg   1200

ctggactgag gttcaggtct ccccccagct gtctcacccc cactttgtcc ccactctaga   1260

gcagggaggc agtgggggag gagttgtgtc ttgtcttctg tctccatgtg gtttttgggt   1320

gtttttcttc ttgtgtcctg gattctgata aaattaaaga aattgcttcc tcaaaaaaaa   1380

aaaaa                                                               1385


<210>  4749
<211>  226
<212>  PRT
<213>  Homosapiens

<400>  4749

Met Ser Val Pro Leu Leu Asn Asp Ala Ala Thr Val Ser Gly Ala Glu 
1               5                   10                  15      


Arg Glu Thr Ala Val Val Ile Phe Leu His Gly Leu Gly Asp Thr Gly 
            20                  25                  30          


His Ser Trp Ala Asp Ala Leu Ser Thr Ile Arg Leu Pro His Val Lys 
        35                  40                  45              


Tyr Ile Cys Ser His Glu Pro Arg Ile Pro Val Thr Leu Asn Met Lys 
    50                  55                  60                  


Met Val Met Pro Ser Trp Phe Asp Leu Met Gly Leu Ser Pro Asp Ala 
65                  70                  75                  80  


Pro Glu Asp Glu Ala Gly Ile Lys Lys Ala Ala Glu Asn Ile Lys Ala 
                85                  90                  95      


Leu Ile Glu His Glu Met Lys Asn Gly Ile Pro Ala Asn Gln Ile Ile 
            100                 105                 110         


Leu Gly Gly Phe Ser Gln Gly Arg Ala Leu Ser Leu Tyr Met Ala Leu 
        115                 120                 125             


Thr Cys Pro His Pro Leu Ala Gly Ile Leu Ala Leu Ser Cys Trp Pro 
    130                 135                 140                 


Pro Leu His Arg Ala Phe Pro Gln Ala Ala Asn Gly Ser Ala Lys Asp 
145                 150                 155                 160 


Leu Ala Ile Leu Gln Cys His Gly Glu Leu Asp Pro Met Val Pro Val 
                165                 170                 175     


Arg Phe Gly Ala Leu Met Ala Glu Lys Leu Arg Ser Val Val Thr Pro 
            180                 185                 190         


Ala Arg Val Gln Phe Gln Thr Tyr Leu Gly Val Met His Ser Ser Cys 
        195                 200                 205             


Pro Gln Glu Met Ala Ala Val Lys Glu Phe Leu Glu Lys Leu Leu Pro 
    210                 215                 220                 


Pro Val 
225     


<210>  4750
<211>  1601
<212>  DNA
<213>  Homosapiens

<400>  4750
ggcgggggcg gccgaggggg aagagtgtgt gtctgcggga gaaagaggag aatcacccaa     60

gcggcctcag aagtcccagg gagtggaggc ccctgccatg gagccgtgtg gtgtatgtgt    120

ggtaacacca tgtctgtgcc cctgctcaac gatgctgcca ccgtgtctgg agctgagcgg    180

gaaacggccg tgggcacagc tgggctgacg ccctctccac cattcggctc cctcacgtca    240

agtacatctg ttcccatgag cctaggatcc ctgtgaccct caacatgaag atggtgatgc    300

cctcctggtt tgacctgatg gggctgagtc cagatgcccc agaggacgag gctggcatca    360

agaaggcagc agagaacatc aaggccttga ttgagcatga aatgaagaac gggatccctg    420

ccaatcaaat catcctggga ggcttttcac agggccgggc cctgtccctc tacatggccc    480

tcacctgccc ccaccctctg gctggcatcc tggctttgag ctgctggccg cctctgcacc    540

gggccttccc ccaggcagct aatggcagtg ccaaggacct ggccatcctc cagtgccatg    600

gggagctgga ccccatggtg cccgtacggt ttggggccct gatggctgag aagctccggt    660

ctgttgtcac acctgccagg gtccagttcc agacatacct gggtgtcatg cacagctcct    720

gtcctcagga gatggcagct gtgaaggaat ttcttgagaa gctgctgcct cctgtctaac    780

tagtcgctgg ccccagtgca gtaccccagc tcatggggga ctcagcaagt aagcatggca    840

ccatcttggg tctgagctgg tcgagcccct gtccccaccc ttcctgacct gtccttttcc    900

cacaggcctc taggggcagg tggcaaggcc tggctgggcc ttccttcctg gcctcagcca    960

cctggctctg tctgcagtag gggcaggctg ctttcttatc ccatttccct ggaggcgggc   1020

ccccctggca gcagtattgg aggggctaca ggcagctgga gaaagaggcc cagccactga   1080

cccactcact caggacctca ctcactagcc ccactttggg ccccctcctg taaccttagg   1140

gtttggccca tggggccctc ccaggcccct gccccaactg attctgccca gataatcttg   1200

tgtctcctgc ctccactcag ctgcttctca gtcatgaacg tggccatggc cccgggggtc   1260

cccttgctgc tgtgggctcc ctgtccctgg gcaggagtgc tggtgaggag gtggagcctt   1320

ttgagggggg ccttccctca gctgtttccc cacactgggg ggctgggccc tgcctccccg   1380

ttaccctcct tccctgcagg cctggagcct gtagggctgg actgaggttc aggtctcccc   1440

ccagctgtct cacccccact ttgtccccac tctagagcag ggaggcagtg ggggaggagt   1500

tgtgtcttgt cttctgtctc catgtggttt ttgggtgttt ttcttcttgt gtcctggatt   1560

ctgataaaat taaagaaatt gcttcctcaa aaaaaaaaaa a                       1601


<210>  4751
<211>  164
<212>  PRT
<213>  Homosapiens

<400>  4751

Met Lys Met Val Met Pro Ser Trp Phe Asp Leu Met Gly Leu Ser Pro 
1               5                   10                  15      


Asp Ala Pro Glu Asp Glu Ala Gly Ile Lys Lys Ala Ala Glu Asn Ile 
            20                  25                  30          


Lys Ala Leu Ile Glu His Glu Met Lys Asn Gly Ile Pro Ala Asn Gln 
        35                  40                  45              


Ile Ile Leu Gly Gly Phe Ser Gln Gly Arg Ala Leu Ser Leu Tyr Met 
    50                  55                  60                  


Ala Leu Thr Cys Pro His Pro Leu Ala Gly Ile Leu Ala Leu Ser Cys 
65                  70                  75                  80  


Trp Pro Pro Leu His Arg Ala Phe Pro Gln Ala Ala Asn Gly Ser Ala 
                85                  90                  95      


Lys Asp Leu Ala Ile Leu Gln Cys His Gly Glu Leu Asp Pro Met Val 
            100                 105                 110         


Pro Val Arg Phe Gly Ala Leu Met Ala Glu Lys Leu Arg Ser Val Val 
        115                 120                 125             


Thr Pro Ala Arg Val Gln Phe Gln Thr Tyr Leu Gly Val Met His Ser 
    130                 135                 140                 


Ser Cys Pro Gln Glu Met Ala Ala Val Lys Glu Phe Leu Glu Lys Leu 
145                 150                 155                 160 


Leu Pro Pro Val 
                


<210>  4752
<211>  1632
<212>  DNA
<213>  Homosapiens

<400>  4752
ggcgggggcg gccgaggggg aagagtgtgt gtctgcggga gaaagaggag aatcacccaa     60

gcggcctcag aagtcccagg gagtggaggc ccctgccatg gagccgtgtg gtgtatgtgt    120

ggtaacacca tgtctgtgcc cctgctcaac gatgctgcca ccgtgtctgg agctgagcgg    180

gaaacggccg tggttatttt tttacatgga cttggagaca cagggcacag ctgggctgac    240

gccctctcca ccattcggct ccctcacgtc aagtacatct gttcccatga gcctaggatc    300

cctgtgaccc tcaacatgaa gatggtgatg ccctcctggt ttgacctgat ggggctgagt    360

ccagatgccc cagaggacga ggctggcatc aagaaggcag cagagaacat caaggccttg    420

attgagcatg aaatgaagaa cgggatccct gccaatcaaa tcatcctggg aggcttttca    480

cagggccggg ccctgtccct ctacatggcc ctcacctgcc cccaccctct ggctggcatc    540

ctggctttga gctgctggcc gcctctgcac cgggccttcc cccaggcagc taatggcagt    600

gccaaggacc tggccatcct ccagtgccat ggggagctgg accccatggt gcccgtacgg    660

tttggggccc tgatggctga gaagctccgg tctgttgtca cacctgccag ggtccagttc    720

cagacatacc tgggtgtcat gcacagctcc tgtcctcagg agatggcagc tgtgaaggaa    780

tttcttgaga agctgctgcc tcctgtctaa ctagtcgctg gccccagtgc agtaccccag    840

ctcatggggg actcagcaag taagcatggc accatcttgg gtctgagctg gtcgagcccc    900

tgtccccacc cttcctgacc tgtccttttc ccacaggcct ctaggggcag gtggcaaggc    960

ctggctgggc cttccttcct ggcctcagcc acctggctct gtctgcagta ggggcaggct   1020

gctttcttat cccatttccc tggaggcggg cccccctggc agcagtattg gaggggctac   1080

aggcagctgg agaaagaggc ccagccactg acccactcac tcaggacctc actcactagc   1140

cccactttgg gccccctcct gtaaccttag ggtttggccc atggggccct cccaggcccc   1200

tgccccaact gattctgccc agataatctt gtgtctcctg cctccactca gctgcttctc   1260

agtcatgaac gtggccatgg ccccgggggt ccccttgctg ctgtgggctc cctgtccctg   1320

ggcaggagtg ctggtgagga ggtggagcct tttgaggggg gccttccctc agctgtttcc   1380

ccacactggg gggctgggcc ctgcctcccc gttaccctcc ttccctgcag gcctggagcc   1440

tgtagggctg gactgaggtt caggtctccc cccagctgtc tcacccccac tttgtcccca   1500

ctctagagca gggaggcagt gggggaggag ttgtgtcttg tcttctgtct ccatgtggtt   1560

tttgggtgtt tttcttcttg tgtcctggat tctgataaaa ttaaagaaat tgcttcctca   1620

aaaaaaaaaa aa                                                       1632


<210>  4753
<211>  226
<212>  PRT
<213>  Homosapiens

<400>  4753

Met Ser Val Pro Leu Leu Asn Asp Ala Ala Thr Val Ser Gly Ala Glu 
1               5                   10                  15      


Arg Glu Thr Ala Val Val Ile Phe Leu His Gly Leu Gly Asp Thr Gly 
            20                  25                  30          


His Ser Trp Ala Asp Ala Leu Ser Thr Ile Arg Leu Pro His Val Lys 
        35                  40                  45              


Tyr Ile Cys Ser His Glu Pro Arg Ile Pro Val Thr Leu Asn Met Lys 
    50                  55                  60                  


Met Val Met Pro Ser Trp Phe Asp Leu Met Gly Leu Ser Pro Asp Ala 
65                  70                  75                  80  


Pro Glu Asp Glu Ala Gly Ile Lys Lys Ala Ala Glu Asn Ile Lys Ala 
                85                  90                  95      


Leu Ile Glu His Glu Met Lys Asn Gly Ile Pro Ala Asn Gln Ile Ile 
            100                 105                 110         


Leu Gly Gly Phe Ser Gln Gly Arg Ala Leu Ser Leu Tyr Met Ala Leu 
        115                 120                 125             


Thr Cys Pro His Pro Leu Ala Gly Ile Leu Ala Leu Ser Cys Trp Pro 
    130                 135                 140                 


Pro Leu His Arg Ala Phe Pro Gln Ala Ala Asn Gly Ser Ala Lys Asp 
145                 150                 155                 160 


Leu Ala Ile Leu Gln Cys His Gly Glu Leu Asp Pro Met Val Pro Val 
                165                 170                 175     


Arg Phe Gly Ala Leu Met Ala Glu Lys Leu Arg Ser Val Val Thr Pro 
            180                 185                 190         


Ala Arg Val Gln Phe Gln Thr Tyr Leu Gly Val Met His Ser Ser Cys 
        195                 200                 205             


Pro Gln Glu Met Ala Ala Val Lys Glu Phe Leu Glu Lys Leu Leu Pro 
    210                 215                 220                 


Pro Val 
225     


<210>  4754
<211>  6010
<212>  DNA
<213>  Homosapiens

<400>  4754
tctcggctgc cgctgctgcc gttggctctt attctcctcc tcctcctcct ctctcctcct     60

ctctgcttct ctctgctcct ctctcctcct ctctcctcct cctcctcctc cacctcctcc    120

tccttctccc cctctttctc cccctctttc tctcttcttt ctcccccgtc cccccgcccc    180

ctccccccag gcctgatgag caggtctcga gcctccatcc atcgggggag catccccgcg    240

atgtcctatg cccccttcag agatgtacgg ggaccctcta tgcaccgaac ccaatacgtt    300

cattccccgt atgatcgtcc tggttggaac cctcggttct gcatcatctc ggggaaccag    360

ctgctcatgc tggatgagga tgagatacac cccctactga tccgggaccg gaggagcgag    420

tccagtcgca acaaactgct gagacgcaca gtctccgtgc cggtggaggg gcggccccac    480

ggcgagcatg aataccactt gggtcgctcg aggaggaaga gtgtcccagg ggggaagcag    540

tacagcatgg agggtgcccc tgctgcgccc ttccggccct cgcaaggctt cctgagccga    600

cggctaaaaa gctccatcaa acgaacgaag tcacaaccca aacttgaccg gaccagcagc    660

tttcgccaga tcctgcctcg cttccgaagt gctgaccatg accgggcccg gctgatgcaa    720

agctttaagg agtcacactc tcatgagtcc ttgctgagtc ctagcagtgc agctgaggca    780

ttggagctca acttggatga agattccatt atcaagccag tgcacagctc catcctgggc    840

caggagttct gttttgaggt aacaacttca tcaggaacaa aatgctttgc ctgtcggtct    900

gcggccgaaa gagacaaatg gattgagaat ctgcagcggg cagtaaagcc caacaaggac    960

aacagccgcc gggtagacaa tgtgctaaag ctgtggatca tagaggcccg ggagctgccc   1020

cccaagaagc ggtactactg tgagctctgc ctggatgaca tgctgtatgc acgcaccacc   1080

tccaagcccc gctctgcctc tggggacacc gtcttctggg gcgagcactt cgagtttaac   1140

aacctgccgg ctgtccgtgc cctgcggctg catctgtacc gtgactcaga caaaaagcgc   1200

aagaaggaca aggcaggcta tgtcggcctg gtgactgtgc cagtggccac cctggctggg   1260

cgccacttca cagagcagtg gtaccctgta accctgccaa caggcagtgg gggatctggg   1320

ggcatgggtt cgggaggggg agggggctcg gggggtggct cagggggcaa gggcaaagga   1380

ggttgcccgg ctgtgcggct gaaagcacgt taccagacaa tgagcatctt gcccatggag   1440

ctatataaag agtttgcaga gtatgtcacc aaccattatc ggatgctgtg tgcagtcttg   1500

gagcccgccc tgaatgtcaa aggcaaggag gaggttgcca gtgcactagt tcacatcctg   1560

cagagtacag gcaaggccaa ggacttcctt tcagacatgg ccatgtctga ggtagaccgg   1620

ttcatggaac gggagcacct catattccgc gagaacacgc ttgccactaa agccatagaa   1680

gagtatatga gactgattgg tcagaaatac ctcaaggatg ccattggaga attcatccgt   1740

gctctgtatg aatctgagga aaactgcgag gtagacccta tcaagtgcac agcatccagt   1800

ttggcagagc accaggccaa cctgcgaatg tgctgtgagt tggccctgtg caaggtggtc   1860

aactcccact gcgtgttccc gagggagctg aaggaggtgt ttgcttcgtg gcggctgcgc   1920

tgcgcagagc gaggccggga ggacatcgca gacaggctta tcagcgcctc actcttcctg   1980

cgcttcctct gcccagcgat tatgtcgccc agtctctttg ggcttatgca ggagtaccca   2040

gatgagcaga cctcacgaac cctcaccctc attgccaagg tcatccagaa cctggccaac   2100

ttttccaagt ttacctcaaa ggaggacttt ctgggcttca tgaatgagtt tctggagctg   2160

gaatggggtt ccatgcagca gtttttgtat gagatctcca atctggacac gctaaccaac   2220

agcagtagct ttgagggtta catcgacttg ggccgagagc tctccacact gcatgcccta   2280

ctctgggagg tgctgcccca gctcagcaag gaagccctcc tgaagctggg tccactgccc   2340

cggctcctca acgacatcag cacagctctg aggaacccca acatccaaag gcagccaagc   2400

cgccagagtg agcggccccg gcctcagcct gtggtactgc gggggccatc ggctgagatg   2460

cagggctaca tgatgcggga cctcaacagc tccatcgacc ttcagtcctt catggctcga   2520

ggcctcaaca gctctatgga catggctcgc ctcccctccc caaccaagga aaagccaccc   2580

ccaccaccgc ctggtggtgg taaagacctg ttctatgtaa gccgtccacc cctggcccgt   2640

tcctcaccag catactgcac gagcagctcg gacatcacag agccagagca gaagatgctg   2700

agtgtcaaca agagtgtgtc catgctggac ttacagggtg atgggcctgg tggccgcctc   2760

aacagcagca gtgtttcgaa cctggcggcc gtaggggacc tgctgcactc aagccaggcc   2820

tcgctgacag cagccttggg gctacggcct gcgcctgccg gacgcctctc ccaggggagt   2880

ggctcatcca tcacggcggc tggcatgcgc ctcagccaga tgggtgtcac cacagacggt   2940

gtccctgccc agcaactgcg aatccccctc tccttccaga accctctctt ccacatggct   3000

gctgatgggc caggtccccc aggcggccat ggagggggcg gtggccatgg cccaccttcc   3060

tcccatcacc accaccacca ccatcaccac caccgaggtg gagagccccc tggggacacc   3120

tttgccccat tccatggcta tagcaagagt gaggacctct cttccggggt ccccaagccc   3180

cctgctgcct ccatccttca tagccacagc tacagtgatg agtttggacc ctctggcact   3240

gacttcaccc gtcggcagct ttcactccag gacaacctgc agcacatgct gtcccctccc   3300

cagatcacca ttggtcccca gaggccagcc ccctcagggc ctggaggtgg gagcggtggg   3360

ggcagcggtg ggggtggcgg gggccagccg cctccattgc agaggggcaa gtctcagcag   3420

ttgacagtca gcgcagccca gaaaccccgg ccatccagcg ggaatctatt gcagtcccca   3480

gagccaagtt atggccccgc ccgtccacgg caacagagcc tcagcaagga gggcagcatt   3540

gggggcagcg ggggcagcgg tggcggaggg ggtggggggc tgaagccctc catcaccaag   3600

cagcattctc agacaccatc cacattgaac cccacaatgc cagcctctga gcggacagtg   3660

gcctgggtct ccaacatgcc tcacctgtcg gctgacatcg agagtgccca catcgagcgg   3720

gaagagtaca agctcaagga gtactcaaaa tcgatggatg agagccggct ggatagggtg   3780

aaggagtacg aggaggagat tcactcactg aaagagcggc tgcacatgtc caaccggaag   3840

ctggaagagt atgagcggag gctgctgtcc caggaagaac aaaccagcaa aatcctgatg   3900

cagtatcagg cccgactgga gcagagtgag aagaggctaa ggcagcagca ggcagagaag   3960

gattcccaga tcaagagcat cattggcagg ctgatgctgg tggaggagga gctgcgccgg   4020

gaccaccccg ccatggctga gccgctgcca gaacccaaga agaggctgct cgacgctcag   4080

gagaggcagc ttcccccctt gggtccaaca aacccgcgtg tgacgctggc cccaccgtgg   4140

aatggcctgg cccccccagc cccaccaccc ccaccccggc tgcagattac ggagaacggc   4200

gagttccgaa acaccgcaga ccactagccc acccagcatc agagaccttc tcttcctttc   4260

ctgtgcaccc caccctgtaa cagcaccaac caccaggatt ggacatcacc gaggaacagc   4320

gggattgcct ccccgaatgc ctccctggga ggcacactga ttgcccaccc ccaccactgc   4380

accatttcca ggagggagag tggggaccct cagccgcccc cttttccttc ccattggggt   4440

gctgccctct ctttgacccc cagggaccct tgccccagga caccgcctac cccgtacaga   4500

ccccttcact ccggggtgct atccccatcc tctgcctcat cgttcccctg agcactgggg   4560

gacagaccct cacccccacc ctgggggtgt ggcacctcca aactttcaac ttcagggtga   4620

tttttttagc agtaaccaga gctgacaatc taactcccct ccaccgcccc attttggcct   4680

cccctgcccc ccttgttatg gggaggggac cccgggtgag ggggccctat taccccttga   4740

tttctcagga gcgtctgggg gggctcagca cgcacaaact ccttctcctt ctaccactct   4800

taaatttact ccctccccac ccagaaccca gatggggtgg agggggccac cggggcaggg   4860

agggggcggc aaggggggaa tgggagttgt ctccccttct ccccacacct gatctgctct   4920

cggctggtcc cagagcgggg tgagggggct tatgcccccc cctcccccag tgtgttgggt   4980

ggggtggaat tgaggttagg gtgaggggtc agggtttagg agggtgtgta tgttgggagg   5040

acaggctagt tgatctgtcc tactctgaca cacagtcccc tctgcccctt ccttctctct   5100

tcttggtctc tactcccagg gggagggggg aacttactct aggaaaagcc atgtctctct   5160

cccccagggt ggggggacct gtgttggagg aggggtgttg gggggccccc ttccatgact   5220

ctgtcccctg ggggaggtag gacagggctg ggcttccctc tcatcctccc cctcccaatc   5280

tccttccacc tccctccctc ccgccagctc cacgattttt cggtgtttct ctgtacatag   5340

ttttctggcg ggatagggga ggtaggatgg atggggtttg gggtgggtag gccatgggag   5400

gggagaagcc cctccttggc accccctctt ccctgactgc tgtcccctac ccagccttgc   5460

ccccttcatc cttttgcgtt tggtattgag actctcctag actctactcc tctttctttt   5520

gtatggacag ttccccttca gtcccatccc cctacacata cacccagccg gggccaaatt   5580

tatacttata taaaagttgt aaatatgtga aattttatcc ctgtgccctt tccccacctc   5640

aggccctacc cctggaccct ccccaacctt ccttctctct tctttggctg ttgtaattat   5700

ctggggtttg tactgtacat atccggggtg tgtgtgtgtg ggctgggggc aacccttctg   5760

tacagagctt cctggccccc tccccccccg cccctctgct tccctcccca cccaccacct   5820

caagggtagg gagttgctct tcctacctgt tttattttgt tttctcgttc tccctcccca   5880

ccccactccc agccttatct atcccccctc actgtcccct tttctccact cccagcccca   5940

tttccttttt ttctggagtg tgtggtgaaa cagaaaaaaa catgtttaat aaacggagat   6000

tgttctttta                                                          6010


<210>  4755
<211>  1328
<212>  PRT
<213>  Homosapiens

<400>  4755

Met Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser Met His Arg 
1               5                   10                  15      


Thr Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp Asn Pro Arg 
            20                  25                  30          


Phe Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp Glu Asp Glu 
        35                  40                  45              


Ile His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser Ser Arg Asn 
    50                  55                  60                  


Lys Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly Arg Pro His 
65                  70                  75                  80  


Gly Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys Ser Val Pro 
                85                  90                  95      


Gly Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala Pro Phe Arg 
            100                 105                 110         


Pro Ser Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser Ile Lys Arg 
        115                 120                 125             


Thr Lys Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe Arg Gln Ile 
    130                 135                 140                 


Leu Pro Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg Leu Met Gln 
145                 150                 155                 160 


Ser Phe Lys Glu Ser His Ser His Glu Ser Leu Leu Ser Pro Ser Ser 
                165                 170                 175     


Ala Ala Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser Ile Ile Lys 
            180                 185                 190         


Pro Val His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe Glu Val Thr 
        195                 200                 205             


Thr Ser Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala Ala Glu Arg 
    210                 215                 220                 


Asp Lys Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro Asn Lys Asp 
225                 230                 235                 240 


Asn Ser Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile Ile Glu Ala 
                245                 250                 255     


Arg Glu Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu Cys Leu Asp 
            260                 265                 270         


Asp Met Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser Ala Ser Gly 
        275                 280                 285             


Asp Thr Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn Leu Pro Ala 
    290                 295                 300                 


Val Arg Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp Lys Lys Arg 
305                 310                 315                 320 


Lys Lys Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val Pro Val Ala 
                325                 330                 335     


Thr Leu Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro Val Thr Leu 
            340                 345                 350         


Pro Thr Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly Cys Pro Ala 
    370                 375                 380                 


Val Arg Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu Pro Met Glu 
385                 390                 395                 400 


Leu Tyr Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr Arg Met Leu 
                405                 410                 415     


Cys Ala Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys Glu Glu Val 
            420                 425                 430         


Ala Ser Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys Ala Lys Asp 
        435                 440                 445             


Phe Leu Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe Met Glu Arg 
    450                 455                 460                 


Glu His Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys Ala Ile Glu 
465                 470                 475                 480 


Glu Tyr Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp Ala Ile Gly 
                485                 490                 495     


Glu Phe Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys Glu Val Asp 
            500                 505                 510         


Pro Ile Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln Ala Asn Leu 
        515                 520                 525             


Arg Met Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn Ser His Cys 
    530                 535                 540                 


Val Phe Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp Arg Leu Arg 
545                 550                 555                 560 


Cys Ala Glu Arg Gly Arg Glu Asp Ile Ala Asp Arg Leu Ile Ser Ala 
                565                 570                 575     


Ser Leu Phe Leu Arg Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu 
            580                 585                 590         


Phe Gly Leu Met Gln Glu Tyr Pro Asp Glu Gln Thr Ser Arg Thr Leu 
        595                 600                 605             


Thr Leu Ile Ala Lys Val Ile Gln Asn Leu Ala Asn Phe Ser Lys Phe 
    610                 615                 620                 


Thr Ser Lys Glu Asp Phe Leu Gly Phe Met Asn Glu Phe Leu Glu Leu 
625                 630                 635                 640 


Glu Trp Gly Ser Met Gln Gln Phe Leu Tyr Glu Ile Ser Asn Leu Asp 
                645                 650                 655     


Thr Leu Thr Asn Ser Ser Ser Phe Glu Gly Tyr Ile Asp Leu Gly Arg 
            660                 665                 670         


Glu Leu Ser Thr Leu His Ala Leu Leu Trp Glu Val Leu Pro Gln Leu 
        675                 680                 685             


Ser Lys Glu Ala Leu Leu Lys Leu Gly Pro Leu Pro Arg Leu Leu Asn 
    690                 695                 700                 


Asp Ile Ser Thr Ala Leu Arg Asn Pro Asn Ile Gln Arg Gln Pro Ser 
705                 710                 715                 720 


Arg Gln Ser Glu Arg Pro Arg Pro Gln Pro Val Val Leu Arg Gly Pro 
                725                 730                 735     


Ser Ala Glu Met Gln Gly Tyr Met Met Arg Asp Leu Asn Ser Ser Ile 
            740                 745                 750         


Asp Leu Gln Ser Phe Met Ala Arg Gly Leu Asn Ser Ser Met Asp Met 
        755                 760                 765             


Ala Arg Leu Pro Ser Pro Thr Lys Glu Lys Pro Pro Pro Pro Pro Pro 
    770                 775                 780                 


Gly Gly Gly Lys Asp Leu Phe Tyr Val Ser Arg Pro Pro Leu Ala Arg 
785                 790                 795                 800 


Ser Ser Pro Ala Tyr Cys Thr Ser Ser Ser Asp Ile Thr Glu Pro Glu 
                805                 810                 815     


Gln Lys Met Leu Ser Val Asn Lys Ser Val Ser Met Leu Asp Leu Gln 
            820                 825                 830         


Gly Asp Gly Pro Gly Gly Arg Leu Asn Ser Ser Ser Val Ser Asn Leu 
        835                 840                 845             


Ala Ala Val Gly Asp Leu Leu His Ser Ser Gln Ala Ser Leu Thr Ala 
    850                 855                 860                 


Ala Leu Gly Leu Arg Pro Ala Pro Ala Gly Arg Leu Ser Gln Gly Ser 
865                 870                 875                 880 


Gly Ser Ser Ile Thr Ala Ala Gly Met Arg Leu Ser Gln Met Gly Val 
                885                 890                 895     


Thr Thr Asp Gly Val Pro Ala Gln Gln Leu Arg Ile Pro Leu Ser Phe 
            900                 905                 910         


Gln Asn Pro Leu Phe His Met Ala Ala Asp Gly Pro Gly Pro Pro Gly 
        915                 920                 925             


Gly His Gly Gly Gly Gly Gly His Gly Pro Pro Ser Ser His His His 
    930                 935                 940                 


His His His His His His His Arg Gly Gly Glu Pro Pro Gly Asp Thr 
945                 950                 955                 960 


Phe Ala Pro Phe His Gly Tyr Ser Lys Ser Glu Asp Leu Ser Ser Gly 
                965                 970                 975     


Val Pro Lys Pro Pro Ala Ala Ser Ile Leu His Ser His Ser Tyr Ser 
            980                 985                 990         


Asp Glu Phe Gly Pro Ser Gly Thr  Asp Phe Thr Arg Arg  Gln Leu Ser 
        995                 1000                 1005             


Leu Gln  Asp Asn Leu Gln His  Met Leu Ser Pro Pro  Gln Ile Thr 
    1010                 1015                 1020             


Ile Gly  Pro Gln Arg Pro Ala  Pro Ser Gly Pro Gly  Gly Gly Ser 
    1025                 1030                 1035             


Gly Gly  Gly Ser Gly Gly Gly  Gly Gly Gly Gln Pro  Pro Pro Leu 
    1040                 1045                 1050             


Gln Arg  Gly Lys Ser Gln Gln  Leu Thr Val Ser Ala  Ala Gln Lys 
    1055                 1060                 1065             


Pro Arg  Pro Ser Ser Gly Asn  Leu Leu Gln Ser Pro  Glu Pro Ser 
    1070                 1075                 1080             


Tyr Gly  Pro Ala Arg Pro Arg  Gln Gln Ser Leu Ser  Lys Glu Gly 
    1085                 1090                 1095             


Ser Ile  Gly Gly Ser Gly Gly  Ser Gly Gly Gly Gly  Gly Gly Gly 
    1100                 1105                 1110             


Leu Lys  Pro Ser Ile Thr Lys  Gln His Ser Gln Thr  Pro Ser Thr 
    1115                 1120                 1125             


Leu Asn  Pro Thr Met Pro Ala  Ser Glu Arg Thr Val  Ala Trp Val 
    1130                 1135                 1140             


Ser Asn  Met Pro His Leu Ser  Ala Asp Ile Glu Ser  Ala His Ile 
    1145                 1150                 1155             


Glu Arg  Glu Glu Tyr Lys Leu  Lys Glu Tyr Ser Lys  Ser Met Asp 
    1160                 1165                 1170             


Glu Ser  Arg Leu Asp Arg Val  Lys Glu Tyr Glu Glu  Glu Ile His 
    1175                 1180                 1185             


Ser Leu  Lys Glu Arg Leu His  Met Ser Asn Arg Lys  Leu Glu Glu 
    1190                 1195                 1200             


Tyr Glu  Arg Arg Leu Leu Ser  Gln Glu Glu Gln Thr  Ser Lys Ile 
    1205                 1210                 1215             


Leu Met  Gln Tyr Gln Ala Arg  Leu Glu Gln Ser Glu  Lys Arg Leu 
    1220                 1225                 1230             


Arg Gln  Gln Gln Ala Glu Lys  Asp Ser Gln Ile Lys  Ser Ile Ile 
    1235                 1240                 1245             


Gly Arg  Leu Met Leu Val Glu  Glu Glu Leu Arg Arg  Asp His Pro 
    1250                 1255                 1260             


Ala Met  Ala Glu Pro Leu Pro  Glu Pro Lys Lys Arg  Leu Leu Asp 
    1265                 1270                 1275             


Ala Gln  Glu Arg Gln Leu Pro  Pro Leu Gly Pro Thr  Asn Pro Arg 
    1280                 1285                 1290             


Val Thr  Leu Ala Pro Pro Trp  Asn Gly Leu Ala Pro  Pro Ala Pro 
    1295                 1300                 1305             


Pro Pro  Pro Pro Arg Leu Gln  Ile Thr Glu Asn Gly  Glu Phe Arg 
    1310                 1315                 1320             


Asn Thr  Ala Asp His 
    1325             


<210>  4756
<211>  1925
<212>  DNA
<213>  Homosapiens

<400>  4756
gaatcaatag gcaggagtca ttttcaaatc aagaaagatc agaatttggt aacagactgg     60

atgagactga taaaggagag cgcccacaat gactctcagg gttccctgga agggacgggg    120

gcgggcatac tgcggtgcta cagaaggtgg cagcagcagg tcccagggct ccagttacag    180

cagctcagac ctgcactcat gccaaggact ctcacagacc ctttccctgc aatgatttca    240

ctgagtgcag actccagcag gtgcgcccac agcgcagctc ctgccctcag gacctctcag    300

gcagttgggg gcagaggcac ctctgtgcag gggcctgtgt tcactcttct gcaaatggcg    360

agtggcaggc tgggaatgaa cctcagggct gtgccttcct taagcctgga ctgttccact    420

gtatcaacat acctgcctca cacaaacaat tctaccagca cgggatcagt aatatttcat    480

acatcagagg tgtgtgagaa actaattttg cctggaagag gggtcagggc aggctacaga    540

gaggaaggtg tgcacaggtg aggccttgag gggttgggag gcagggaggg gagctgcttt    600

ccaggcaaag ggaacgagga gaagatttcc acataaagat ctgggccttg gcacctcact    660

cctggcagcc tgtctgtaat tcactctggt cacccctctg tggagcagtg tgcctgcctc    720

agtcatctct gttgatgatt taagcctagc agccttcagc caaatgtggc aactgtgtaa    780

gccaataccc agctagctcc tggaccactc ggatgcccat caacatgtac gaggctgggg    840

ttacttctcc tgggatccca gaaatcctca gatttgcacg caatgcaaat gggcattcgg    900

gggggcctgt gggtggtccc gattctgttc ttgggagcgg gagtgaaaag caagcctgtc    960

gtggggaaac tggcaccttc actggtggcc acgctgctgg ggctgggcgt gaagctgcct   1020

ccggcccttg gagaggagtg tgagggaagg gaggcggcag tgctttttat acacaggagc   1080

tggaggaggg tgatggcagc ttggaggaag tcatcactgc catggtaggg gggaaatctg   1140

gaaatattgg gcatgtggcc ctccccttcc caccgtaacc ccaagctcct cagcccactt   1200

ctttccacca ggcacctttg ggcttccctc taggtggaac agccaagtcc tgagtctctt   1260

tgctcagaag ctcaagtgat tcaatttctt ttctccaaac tttcccaaga ctgcaatacc   1320

tcttggaaag gacgtgacca aatgtggctg agacacactg ggcagagccg cactactcat   1380

ttatgcaaaa ccattactct ggccgccgca tcagtctccc ttcccctttt cagcaatcat   1440

gtatcccatt agcctgtttg attgccgctg ctcacaaagg ggcgccttcg ctgaaccgtc   1500

ttcaatggcc tctggatctc tcccctgaga gaagccggct aatttggaat gtggtcgtgt   1560

gtatgaatcc gacacagcct cagtcacaat cgggtgtcct tttctgtagc tgctgtttat   1620

gatcactttg ccttgcctct ctgggagcca taattcacca catactggag ataggctggg   1680

tgttcttttc cccgtgaatc ctggacagga tgtacacaaa tgtgctagcc ccttcttggt   1740

gaccaggcta attcctcagt ggcttggtgg ctgctgcctc tcattagagg gattccctaa   1800

gcactatttg cttgacaaat tttcaaggtt tttaaaagca gaagcctttg ctaattttcc   1860

caagttggcc taagagtcca ctgtgaactg cagcagaaat tggggaaatt taataaatgt   1920

tgatc                                                               1925


<210>  4757
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  4757

Met Arg Leu Ile Lys Glu Ser Ala His Asn Asp Ser Gln Gly Ser Leu 
1               5                   10                  15      


Glu Gly Thr Gly Ala Gly Ile Leu Arg Cys Tyr Arg Arg Trp Gln Gln 
            20                  25                  30          


Gln Val Pro Gly Leu Gln Leu Gln Gln Leu Arg Pro Ala Leu Met Pro 
        35                  40                  45              


Arg Thr Leu Thr Asp Pro Phe Pro Ala Met Ile Ser Leu Ser Ala Asp 
    50                  55                  60                  


Ser Ser Arg Cys Ala His Ser Ala Ala Pro Ala Leu Arg Thr Ser Gln 
65                  70                  75                  80  


Ala Val Gly Gly Arg Gly Thr Ser Val Gln Gly Pro Val Phe Thr Leu 
                85                  90                  95      


Leu Gln Met Ala Ser Gly Arg Leu Gly Met Asn Leu Arg Ala Val Pro 
            100                 105                 110         


Ser Leu Ser Leu Asp Cys Ser Thr Val Ser Thr Tyr Leu Pro His Thr 
        115                 120                 125             


Asn Asn Ser Thr Ser Thr Gly Ser Val Ile Phe His Thr Ser Glu Val 
    130                 135                 140                 


Cys Glu Lys Leu Ile Leu Pro Gly Arg Gly Val Arg Ala Gly Tyr Arg 
145                 150                 155                 160 


Glu Glu Gly Val His Arg 
                165     


<210>  4758
<211>  1925
<212>  DNA
<213>  Homosapiens

<400>  4758
gaatcaatag gcaggagtca ttttcaaatc aagaaagatc agaatttggt aacagactgg     60

atgagactga taaaggagag cgcccacaat gactctcagg gttccctgga agggacgggg    120

gcgggcatac tgcggtgcta cagaaggtgg cagcagcagg tcccagggct ccagttacag    180

cagctcagac ctgcactcat gccaaggact ctcacagacc ctttccctgc aatgatttca    240

ctgagtgcag actccagcag gtgcgcccac agcgcggctc ctgccctcag gacctctcag    300

gcagttgggg gcagaggcac ctctgtgcag gggcctgtgt tcactcttct gcaaatggcg    360

agtggcaggc tgggaatgaa cctcagggct gtgccttcct taagcctgga ctgttccact    420

gtatcaacat acctgcctca cacaaacaat tctaccagca cgggatcagt aatatttcat    480

acatcagagg tgtgtgagaa actaattttg cctggaagag gggtcagggc aggctacaga    540

gaggaaggtg tgcacaggtg aggccttgag gggttgggag gcagggaggg gagctgcttt    600

ccaggcaaag ggaacgagga gaagatttcc acataaagat ctgggccttg gcacctcact    660

cctggtagcc tgtctgtaat tcactctggt cacccctctg tggagcagtg tgcctgcctc    720

agtcatctct gttgatgatt taagcctagc agccttcagc caaatgtggc aactgtgtaa    780

gccaataccc agctagctcc tggaccactc ggatgcccat caacatgtac gaggctgggg    840

ttacttctcc tgggatccca gaaatcctca gatttgcacg caatgcaaat gggcattcgg    900

gggggcctgt gggtggtccc gattctgttc ttgggagcgg gagtgaaaag caagcctgtc    960

gtggggaaac tggcaccttc actggtggcc acgctgctgg ggctgggcgt gaagctgcct   1020

ccggcccttg gagaggagtg tgagggaagg gaggcggcag tgctttttat acacaggagc   1080

tggaggaggg tgatggcagc ttggaggaag tcatcactgc catggtaggg gggaaatctg   1140

gaaatattgg gcatgtggcc ctccccttcc caccgtaacc ccaagctcct cagcccactt   1200

ctttccacca ggcacctttg ggcttccctc taggtggaac agccaagtcc tgagtctctt   1260

tgctcagaag ctcaagtgat tcaatttctt ttctccaaac tttcccaaga ctgcaatacc   1320

tcttggaaag gacgtgacca aatgtggctg agacacactg ggcagagccg cactactcat   1380

ttatgcaaaa ccattactct ggccgccgca tcagtctccc ttcccctttt cagcaatcat   1440

gtatcccatt agcctgtttg attgccgctg ctcacaaagg ggcgccttcg ctgaaccgtc   1500

ttcaatggcc tctggatctc tcccctgaga gaagccggct aatttggaat gtggtcgtgt   1560

gtatgaatcc gacacagcct cagtcacaat cgggtgtcct tttctgtagc tgctgtttat   1620

gatcactttg ccttgcctct ctgggagcca taattcacca catactggag ataggctggg   1680

tgttcttttc cccgtgaatc ctggacagga tgtacacaaa tgtgctagcc ccttcttggt   1740

gaccaggcta attcctcagt ggcttggtgg ctgctgcctc tcattagagg gattccctaa   1800

gcactatttg cttgacaaat tttcaaggtt tttaaaagca gaagcctttg ctaattttcc   1860

caagttggcc taagagtcca ctgtgaactg cagcagaaat tggggaaatt taataaatgt   1920

tgatc                                                               1925


<210>  4759
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  4759

Met Arg Leu Ile Lys Glu Ser Ala His Asn Asp Ser Gln Gly Ser Leu 
1               5                   10                  15      


Glu Gly Thr Gly Ala Gly Ile Leu Arg Cys Tyr Arg Arg Trp Gln Gln 
            20                  25                  30          


Gln Val Pro Gly Leu Gln Leu Gln Gln Leu Arg Pro Ala Leu Met Pro 
        35                  40                  45              


Arg Thr Leu Thr Asp Pro Phe Pro Ala Met Ile Ser Leu Ser Ala Asp 
    50                  55                  60                  


Ser Ser Arg Cys Ala His Ser Ala Ala Pro Ala Leu Arg Thr Ser Gln 
65                  70                  75                  80  


Ala Val Gly Gly Arg Gly Thr Ser Val Gln Gly Pro Val Phe Thr Leu 
                85                  90                  95      


Leu Gln Met Ala Ser Gly Arg Leu Gly Met Asn Leu Arg Ala Val Pro 
            100                 105                 110         


Ser Leu Ser Leu Asp Cys Ser Thr Val Ser Thr Tyr Leu Pro His Thr 
        115                 120                 125             


Asn Asn Ser Thr Ser Thr Gly Ser Val Ile Phe His Thr Ser Glu Val 
    130                 135                 140                 


Cys Glu Lys Leu Ile Leu Pro Gly Arg Gly Val Arg Ala Gly Tyr Arg 
145                 150                 155                 160 


Glu Glu Gly Val His Arg 
                165     


<210>  4760
<211>  827
<212>  DNA
<213>  Homosapiens

<400>  4760
gtggcgtgct cgctttggcc atccatgtcc ctcgtgttgg acactagagc tgtccccgat     60

gtacccatac tgacctggtc acgaatcgcc ttgagaggct ggaaactcac ccgcctcctt    120

tcccggacta gggggaagtg gggtgaagga ggcgtgcagg gaggaacctg ggggaggggg    180

tggcccgtct cccaggctgg gcgtgggccg ggcgaggtcc ccagcccacc gggccgtgcc    240

aacaatggcc tgttgtagaa ggaggcggga aggaatgcgg cctggggagc tgggcggcgg    300

cggggcgggg cccggccaag cggctgcctt ttacctggcc aggtagctcg catttcccgg    360

caagcggcgg cgcccgcagc acctgttgcc cggtgcgcgg gcggggagga cggcggggga    420

catggcctgg tagagtcccc tggggaaacc gtgctgagtt cagtccgggg cagggcaggg    480

cgagggaggg aaggtccttc cctggcgccc gcgcgggctg cggcagcatg aaaaagaagc    540

agacggtgca gggcaccttc agcaaactct tcgggaagaa gcacaccacg acccccagca    600

cctccctcta cgccaccaat ccgccctgga tcttcaccca ggaggccccg gaggagggga    660

ccgggggctt cgatggcatc tattatggag acaatcggtt taacacagtg agcgagtcag    720

gaacagccac gctgaaagct cggccaagag tccggcccct gctgaccttc cttccgctga    780

ctgagtttca ttcttgttgc ccaggctgga gtggtacaat ggcgtga                  827


<210>  4761
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  4761

Met Lys Lys Lys Gln Thr Val Gln Gly Thr Phe Ser Lys Leu Phe Gly 
1               5                   10                  15      


Lys Lys His Thr Thr Thr Pro Ser Thr Ser Leu Tyr Ala Thr Asn Pro 
            20                  25                  30          


Pro Trp Ile Phe Thr Gln Glu Ala Pro Glu Glu Gly Thr Gly Gly Phe 
        35                  40                  45              


Asp Gly Ile Tyr Tyr Gly Asp Asn Arg Phe Asn Thr Val Ser Glu Ser 
    50                  55                  60                  


Gly Thr Ala Thr Leu Lys Ala Arg Pro Arg Val Arg Pro Leu Leu Thr 
65                  70                  75                  80  


Phe Leu Pro Leu Thr Glu Phe His Ser Cys Cys Pro Gly Trp Ser Gly 
                85                  90                  95      


Thr Met Ala 
            


<210>  4762
<211>  399
<212>  DNA
<213>  Homosapiens

<400>  4762
tctcaccccc caagcggata ctggtcttct cgtcggattg cccatgcact tgttgcagaa     60

acagccaagg ccctggctgt ggagaatgct gaaggaagaa gacgcagaag caggacgacc    120

ctgaaagatt cagcctcttc atcctcaaac aggtcgcttc tcgggagttc ttggtgttgg    180

aatattttac agcaaagcag tcgaccaggc ctcctcttcc cacctgtcca gcagcatgaa    240

agcagcatga ttggccgacc gcaggagaag cccccagaac caggccccca actcagccat    300

ctgcggaggt caagaccttt cagctggatc atctgtcaac ctcaccgcca ccaggtgtga    360

gcgacgtctc ctcaccacag tgctgtgtgg tctatacct                           399


<210>  4763
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  4763

Met Ile Gly Arg Pro Gln Glu Lys Pro Pro Glu Pro Gly Pro Gln Leu 
1               5                   10                  15      


Ser His Leu Arg Arg Ser Arg Pro Phe Ser Trp Ile Ile Cys Gln Pro 
            20                  25                  30          


His Arg His Gln Val 
        35          


<210>  4764
<211>  399
<212>  DNA
<213>  Homosapiens

<400>  4764
tctcaccccc caagcggata ctggtcttct cgtcggattg cccatgcact tgttgcagaa     60

acagccaagg ccctggctgt ggagaatgct gaaggaagaa gacgcagaag caggacgacc    120

ctgaaagatt cagcctcttc atcctcaaac aggtcgcttc tcgggagttc ttggtgttgg    180

aatattttac agcaaagcag tcgaccaggc ctcctcttcc cacctgtcca gcagcatgaa    240

agcagcatga ttggccgacc gcaggagaag cccccagaac caggccccca actcagccat    300

ctgcggaggt caagaccttt cagctggatc atctgtcaac ctcaccgcca ccaggtgtga    360

gcgacgtctc ctcaccacag tgctgtgtgg tctatacct                           399


<210>  4765
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  4765

Met Ile Gly Arg Pro Gln Glu Lys Pro Pro Glu Pro Gly Pro Gln Leu 
1               5                   10                  15      


Ser His Leu Arg Arg Ser Arg Pro Phe Ser Trp Ile Ile Cys Gln Pro 
            20                  25                  30          


His Arg His Gln Val 
        35          


<210>  4766
<211>  704
<212>  DNA
<213>  Homosapiens

<400>  4766
ggggcagccg tgagcagcgg gcacacgggc agccacgaaa gcagcagcga gggtggtgca     60

aacacctcaa aactacaccg aatccagtag cgcctggcgc ccccggcgcg caaggccgcc    120

tctactccgc ctcatctttg tcccaagtcc tttcacagtc tgccttcctc aaacggcccg    180

atgcgccccc gtctttgccg gagtaagcag accgccagca gccggcccgc aggtcagtcg    240

accctctctg gatgcaggtc gccgggaaaa cccggagcgg agcatccctc gggccgggaa    300

acgccctcgg cgcgcaccca ctggcgcgca tgctcagtcc gcgcggcggc tgcgagtagg    360

aagctccgcg cggcggcggg ggcggcgacg gcgactggcg ggtgggagtg gaggcaccgg    420

ctggcgggcg ggggtacagg gacggggcag gggctcccgc tccaggttcc ttgaagcact    480

tccgaccgcg aagcccggcg cgagaagcga gctaacccaa gagccaacaa cgagcgcgga    540

gagggcagcg gactgagcgg agccgccggc cagagcgggc tcggagcccg ggtctccgcc    600

gctcgggacc cggctaggcg gcggcggggg cggcgatgtt ccactgcatc cccctgtggc    660

ggtgcaaccg tcatgtggag agcatcgaca agcgccactg ctcg                     704


<210>  4767
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  4767

Met Arg Pro Arg Leu Cys Arg Ser Lys Gln Thr Ala Ser Ser Arg Pro 
1               5                   10                  15      


Ala Gly Gln Ser Thr Leu Ser Gly Cys Arg Ser Pro Gly Lys Pro Gly 
            20                  25                  30          


Ala Glu His Pro Ser Gly Arg Glu Thr Pro Ser Ala Arg Thr His Trp 
        35                  40                  45              


Arg Ala Cys Ser Val Arg Ala Ala Ala Ala Ser Arg Lys Leu Arg Ala 
    50                  55                  60                  


Ala Ala Gly Ala Ala Thr Ala Thr Gly Gly Trp Glu Trp Arg His Arg 
65                  70                  75                  80  


Leu Ala Gly Gly Gly Thr Gly Thr Gly Gln Gly Leu Pro Leu Gln Val 
                85                  90                  95      


Pro 
    


<210>  4768
<211>  704
<212>  DNA
<213>  Homosapiens

<400>  4768
ggggcagccg tgagcagcgg gcacacgggc agccacgaaa gcagcagcga gggtggtgca     60

aacacctcaa aactacaccg aatccagtag cgcctggcgc ccccggcgcg caaggccgcc    120

tctactccgc ctcatctttg tcccaagtcc tttcacagtc tgccttcctc aaacggcccg    180

atgcgccccc gtctttgccg gagtaagcag accgccagca gccggcccgc aggtcagtcg    240

accctctctg gatgcaggtc gccgggaaaa cccggagcgg agcatccctc gggccgggaa    300

acgccctcgg cgcgcaccca ctggcgcgca tgctcagtcc gcgcggcggc tgcgagtagg    360

aagctccgcg cggcggcggg ggcggcgacg gcgactggcg ggtgggagtg gaggcaccgg    420

ctggcgggcg ggggtacagg gacggggcag gggctcccgc tccaggttcc ttgaagcact    480

tccgaccgcg aagcccggcg cgagaagcga gctaacccaa gagccaacaa cgagcgcgga    540

gagggcagcg gactgagcgg agccgccggc cagagcgggc tcggagcccg ggtctccgcc    600

gctcgggacc cggctaggcg gcggcggggg cggcgatgtt ccactgcatc cccctgtggc    660

ggtgcaaccg tcatgtggag agcatcgaca agcgccactg ctcg                     704


<210>  4769
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  4769

Met Arg Pro Arg Leu Cys Arg Ser Lys Gln Thr Ala Ser Ser Arg Pro 
1               5                   10                  15      


Ala Gly Gln Ser Thr Leu Ser Gly Cys Arg Ser Pro Gly Lys Pro Gly 
            20                  25                  30          


Ala Glu His Pro Ser Gly Arg Glu Thr Pro Ser Ala Arg Thr His Trp 
        35                  40                  45              


Arg Ala Cys Ser Val Arg Ala Ala Ala Ala Ser Arg Lys Leu Arg Ala 
    50                  55                  60                  


Ala Ala Gly Ala Ala Thr Ala Thr Gly Gly Trp Glu Trp Arg His Arg 
65                  70                  75                  80  


Leu Ala Gly Gly Gly Thr Gly Thr Gly Gln Gly Leu Pro Leu Gln Val 
                85                  90                  95      


Pro 
    


<210>  4770
<211>  3092
<212>  DNA
<213>  Homosapiens

<400>  4770
tgtcaggctg tggctctctt tctcacagag aatgccagag gcactcggga aggcatttgc     60

cagggctctg acagatgtaa agtaagcctt atccatgttg tgttctcacc tggacacctg    120

gaaggtgctc agtatagaaa agtcacgagc tagatgagat accagcttga tgtcgactcc    180

ctccccaaca atggctgcct gtcttcgtct tgatgcctgc cagcaggaaa gcactgtctt    240

agaacctggc tcacctgatt ttgccgatga gtcaactttg aagtgtgcct cattctggaa    300

agtgaatcac gtaatcacaa tggagtctcc ctcttgttgc ccaggctgga gtgcaatggt    360

gtgatcttgg ctcactgcaa cctccacctc ccagtagata cggggtttca tcatgttggc    420

caggctgatt tcgaactcct gacctcaaga gagctgcccg cctcgacttc ccaaagtgct    480

aggattacag gcatgagcca tcacacccag cctcatatat tgtattctgt atataattaa    540

gacctttcct tttcaaggca atatatataa caataaaaag atgaattaag taagccctct    600

gaattaatat attaagtggt ccctcagaag ggagaaattt tgaaattaaa tattatctaa    660

agattttgat attcacttaa tgggagtatc tgaattaagt gtcacaacta aaatagtaga    720

gtggtcacat tccctagcac cagttctcaa actttgttaa aaatgcagat tcctgagctc    780

tatcattaaa catttttatt tagaagtggg gagtgtggcc ttcgtatttc agctgcttaa    840

ctagtagcac agcgaagacg gtataagggt ctttggatca ctttttgaaa agcatggtct    900

tagagagaag gaacagccca cactcgttca cagtgtagca acacgcggga aagagaacag    960

tcaaattgtt ttgatgatga cgaaaggaaa tgcaggcttt ctagtatata caaaacatat   1020

tcaaaaatct agaagtttat cactaaggtt tttggaagta aatctacatt tagcaactca   1080

attttttaga ttttattctc aattatctgg acatgagatt taggtctgtg attctcaggt   1140

cttcttagtt atacatatca ctcaaggagc tatggactcc aaatgactta tgtttgtgat   1200

aaagcctcat ttaccccaca ataataggaa agctgctctg attttctgaa gttagaaatg   1260

aaagattaag taagtacatt tgttatagtt taatattaca cattgtatga tgaaaacatt   1320

gtctcctaca ctgcctccta ttatctggaa aattagtaat actaaagtgt tctttcaaaa   1380

ccagagacct aaatggctgg aagcaataat tgctagagct ctccaccaag ctttgactat   1440

aaatatttgg ccatattgtg tgttagaaaa tataagacac acttgctttc attttctgag   1500

cctgactcac tgaattttct tgtccagatt ggttttcatc tgtttattcc tttagagcat   1560

agattagagt ccattgtggt tctcatctct gttatgcatg tttttttatg aataaaatgc   1620

caggcacaca gagcatacat atgcacattt tactacgaga tagtaaaagc tcaatgtgct   1680

gggactgcat tcccaatgtg accttatttt cccactcttt gcagttttaa aatgttacgt   1740

taatctggcg ttctggacgg ggattttctc ttctttacag tgagtcccag cagtatatag   1800

cggccataga atagctaaac ttgaagaggc tttttggcaa agatttgaat atatgtcctt   1860

tggccttttc tggttcttgt ctgtatttca taatacaaaa ctaatgagga tttcactttg   1920

gtgaaatctg ccttactaaa tgatgcttgc aaataacaca ttcatttgtt agcatttggg   1980

attctgatta aatcattttg ctttagtagc tgttaaagat tatagtttga aagaaaaaag   2040

tgttttggca ttgagtactt tgagacccct gtacagtgta ccaaaatcta tgcaaattgt   2100

tacgaggcct tttaattaca ggtgaacccc agcacttatt atcatctgat gcacagatta   2160

tgcacatgtc atatattggt aataaaatat caaagttaga ctgacactct taaagtgctt   2220

aacactgttt tattggctta ctagccctaa ctggattcat tgcatccatt tttttcattc   2280

tgccacttaa aacatttgcc acgttgtttt attcatgctt ttatcacagc tttgtctgta   2340

actacattga cttgattact catattctat ggcaattcct gacatttggc ttatttttcc   2400

actagcctcc ttacttttaa aaaccactcc atctcatttt tcaacaacct ctgattatct   2460

caaagttacc tcggattatc ctgacacgtc cttcggcttc tgaggatatt gactcagtat   2520

ttcaagactg aggtgactct gagacagaag acggagccag tggtgatgtg ctcccttatt   2580

cagactcttt gaataatgct ttttactcag ctatggactc tgctagaaag acactttaat   2640

atttttgcca tttatatttt tctgttgttg aaaaataata gaaaccagtg ccttagttgg   2700

tttaacaatt caacaaagtt gttttcaaaa gaagaaagaa aatgtaactc catttaggtt   2760

gtctttcatt tgcaaacact aactgaaact tgagttaggg attgtataac ttggaaacag   2820

tattaataaa atgaagtcat tgtcatatta aaaatgtcct aatgttcact ttaagtgtat   2880

ttttaaaaac ctcacaggca atggtgtgaa agaaaccaag gagatgttta cattcattag   2940

ttccactgga aaaaactggt taatgtaatt gtatagattt ttcccttctt gttttgtgtg   3000

ctgtataacc cagtctttgc tttatgtaca aataccctgg tttctaaatg ctacttattt   3060

tcttcagaaa taaagtatgc tttcaattta gt                                 3092


<210>  4771
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  4771

Met Ser Thr Pro Ser Pro Thr Met Ala Ala Cys Leu Arg Leu Asp Ala 
1               5                   10                  15      


Cys Gln Gln Glu Ser Thr Val Leu Glu Pro Gly Ser Pro Asp Phe Ala 
            20                  25                  30          


Asp Glu Ser Thr Leu Lys Cys Ala Ser Phe Trp Lys Val Asn His Val 
        35                  40                  45              


Ile Thr Met Glu Ser Pro Ser Cys Cys Pro Gly Trp Ser Ala Met Val 
    50                  55                  60                  


<210>  4772
<211>  3092
<212>  DNA
<213>  Homosapiens

<400>  4772
tgtcaggctg tggctctctt tctcacagag aatgccagag gcactcggga aggcatttgc     60

cagggctctg acagatgtaa agtaagcctt atccatgttg tgttctcacc tggacacctg    120

gaaggtgctc agtatagaaa agtcacgagc tagatgagat accagcttga tgtcgactcc    180

ctccccaaca atggctgcct gtcttcgtct tgatgcctgc cagcaggaaa gcactgtctt    240

agaacctggc tcacctgatt ttgccgatga gtcaactttg aagtgtgcct cattctggaa    300

agtgaatcac gtaatcacaa tggagtctcc ctcttgttgc ccaggctgga gtgcaatggt    360

gtgatcttgg ctcactgcaa cctccacctc ccagtagata cggggtttca tcatgttggc    420

caggctgatt tcgaactcct gacctcaaga gagctgcccg cctcgacttc ccaaagtgct    480

aggattacag gcatgagcca tcacacccag cctcatatat tgtattctgt atataattaa    540

gacctttcct tttcaaggca atatatataa caataaaaag atgaattaag taagccctct    600

gaattaatat attaagtggt ccctcagaag ggagaaattt tgaaattaaa tattatctaa    660

agattttgat attcacttaa tgggagtatc tgaattaagt gtcacaacta aaatagtaga    720

gtggtcacat tccctagcac cagttctcaa actttgttaa aaatgcagat tcctgagctc    780

tatcattaaa catttttatt tagaagtggg gagtgtggcc ttcgtatttc agctgcttaa    840

ctagtagcac agcgaagacg gtataagggt ctttggatca ctttttgaaa agcatggtct    900

tagagagaag gaacagccca cactcgttca cagtgtagca acacgcggga aagagaacag    960

tcaaattgtt ttgatgatga cgaaaggaaa tgcaggcttt ctagtatata caaaacatat   1020

tcaaaaatct agaagtttat cactaaggtt tttggaagta aatctacatt tagcaactca   1080

attttttaga ttttattctc aattatctgg acatgagatt taggtctgtg attctcaggt   1140

cttcttagtt atacatatca ctcaaggagc tatggactcc aaatgactta tgtttgtgat   1200

aaagcctcat ttaccccaca ataataggaa agctgctctg attttctgaa gttagaaatg   1260

aaagattaag taagtacatt tgttatagtt taatattaca cattgtatga tgaaaacatt   1320

gtctcctaca ctgcctccta ttatctggaa aattagtaat actaaagtgt tctttcaaaa   1380

ccagagacct aaatggctgg aagcaataat tgctagagct ctccaccaag ctttgactat   1440

aaatatttgg ccatattgtg tgttagaaaa tataagacac acttgctttc attttctgag   1500

cctgactcac tgaattttct tgtccagatt ggttttcatc tgtttattcc tttagagcat   1560

agattagagt ccattgtggt tctcatctct gttatgcatg tttttttatg aataaaatgc   1620

caggcacaca gagcatacat atgcacattt tactacgaga tagtaaaagc tcaatgtgct   1680

gggactgcat tcccaatgtg accttatttt cccactcttt gcagttttaa aatgttacgt   1740

taatctggcg ttctggacgg ggattttctc ttctttacag tgagtcccag cagtatatag   1800

cggccataga atagctaaac ttgaagaggc tttttggcaa agatttgaat atatgtcctt   1860

tggccttttc tggttcttgt ctgtatttca taatacaaaa ctaatgagga tttcactttg   1920

gtgaaatctg ccttactaaa tgatgcttgc aaataacaca ttcatttgtt agcatttggg   1980

attctgatta aatcattttg ctttagtagc tgttaaagat tatagtttga aagaaaaaag   2040

tgttttggca ttgagtactt tgagacccct gtacagtgta ccaaaatcta tgcaaattgt   2100

tacgaggcct tttaattaca ggtgaacccc agcacttatt atcatctgat gcacagatta   2160

tgcacatgtc atatattggt aataaaatat caaagttaga ctgacactct taaagtgctt   2220

aacactgttt tattggctta ctagccctaa ctggattcat tgcatccatt tttttcattc   2280

tgccacttaa aacatttgcc acgttgtttt attcatgctt ttatcacagc tttgtctgta   2340

actacattga cttgattact catattctat ggcaattcct gacatttggc ttatttttcc   2400

actagcctcc ttacttttaa aaaccactcc atctcatttt tcaacaacct ctgattatct   2460

caaagttacc tcggattatc ctgacacgtc cttcggcttc tgaggatatt gacccagtat   2520

ttcaagactg aggtgactct gagacagaag acggagccag tggtgatgtg ctcccttatt   2580

cagactcttt gaataatgct ttttactcag ctatggactc tgctagaaag acactttaat   2640

atttttgcca tttatatttt tctgttgttg aaaaataata gaaaccagtg ccttagttgg   2700

tttaacaatt caacaaagtt gttttcaaaa gaagaaagaa aatgtaactc catttaggtt   2760

gtctttcatt tgcaaacact aactgaaact tgagttaggg attgtataac ttggaaacag   2820

tattaataaa atgaagtcat tgtcatatta aaaatgtcct aatgttcact ttaagtgtat   2880

ttttaaaaac ctcacaggca atggtgtgaa agaaaccaag gagatgttta cattcattag   2940

ttccactgga aaaaactggt taatgtaatt gtatagattt ttcccttctt gttttgtgtg   3000

ctgtataacc cagtctttgc tttatgtaca aataccctgg tttctaaatg ctacttattt   3060

tcttcagaaa taaagtatgc tttcaattta gt                                 3092


<210>  4773
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  4773

Met Ser Thr Pro Ser Pro Thr Met Ala Ala Cys Leu Arg Leu Asp Ala 
1               5                   10                  15      


Cys Gln Gln Glu Ser Thr Val Leu Glu Pro Gly Ser Pro Asp Phe Ala 
            20                  25                  30          


Asp Glu Ser Thr Leu Lys Cys Ala Ser Phe Trp Lys Val Asn His Val 
        35                  40                  45              


Ile Thr Met Glu Ser Pro Ser Cys Cys Pro Gly Trp Ser Ala Met Val 
    50                  55                  60                  


<210>  4774
<211>  324
<212>  DNA
<213>  Homosapiens

<400>  4774
atgtgggtcc tcagtaaggc cccacctttg ggccagggag gccctgaagg ctgggggaca     60

ggctgccagt cccgtggacc agaatgggga ctcgtggtgc ctgttctggg cacacccatg    120

gcagcccatg gaccaattag catgtacttc ctcccctctg aggtccgtaa aagccctggg    180

ctcagtcaga gcagggcaaa ggacggccag aggacaaagg gagacatggg acctgatgac    240

cagctgcaga aaggagtacc ctctctgctg agagttggag acaatgccat gaccagctgc    300

agagaagagt acactctctg ctaa                                           324


<210>  4775
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  4775

Met Trp Val Leu Ser Lys Ala Pro Pro Leu Gly Gln Gly Gly Pro Glu 
1               5                   10                  15      


Gly Trp Gly Thr Gly Cys Gln Ser Arg Gly Pro Glu Trp Gly Leu Val 
            20                  25                  30          


Val Pro Val Leu Gly Thr Pro Met Ala Ala His Gly Pro Ile Ser Met 
        35                  40                  45              


Tyr Phe Leu Pro Ser Glu Val Arg Lys Ser Pro Gly Leu Ser Gln Ser 
    50                  55                  60                  


Arg Ala Lys Asp Gly Gln Arg Thr Lys Gly Asp Met Gly Pro Asp Asp 
65                  70                  75                  80  


Gln Leu Gln Lys Gly Val Pro Ser Leu Leu Arg Val Gly Asp Asn Ala 
                85                  90                  95      


Met Thr Ser Cys Arg Glu Glu Tyr Thr Leu Cys 
            100                 105         


<210>  4776
<211>  769
<212>  DNA
<213>  Homosapiens

<400>  4776
atgaggacta atctcagtca tgactatgat aatctcaacg gtactatggg gggcattttc     60

aatgaattgg ctctcagtat tttggcttta agcttctgtt tccatcttta tattatcaag    120

aattgttcag ttggtggttt ccgcttttcc gtcttcctca ttctctcttt gccagctgcc    180

atccacatca accctgagga ttgggaagga attatacata ccaggaggca aggagcactg    240

ggggccctcc tgggactgcc tatcacagcg tccttaaagg ttttcactct cctaggatga    300

cccaggtata gaatctgccc ctatggttca gctccaccct ctcacctgtc tcttgagagc    360

attgtgaagt tctgagacac agcaaggaca gaaacagagg gcatggaaga tgctttcaaa    420

gatcagatcc agagcctgac aagtttattt acttggagaa gcagattcta ggttctagaa    480

aagaaggctg aaaatacaac tttaagggaa aggataatct gatgactaat tctcatttat    540

caaaaagcca ctttgcctta gatctatctc tataaactcc atgcttcacc ataaaatcct    600

tctaacttta ttgaaaaaag ggggccacct ggcaaataac accaagagta ttatttctgg    660

gttcatttaa cccaacgaca attatttatc ttactaaaat ccatttctag gtctacaaac    720

ctattgtgta gttcatgaat acataggctt tagtcctaga tagttggag                769


<210>  4777
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  4777

Met Arg Thr Asn Leu Ser His Asp Tyr Asp Asn Leu Asn Gly Thr Met 
1               5                   10                  15      


Gly Gly Ile Phe Asn Glu Leu Ala Leu Ser Ile Leu Ala Leu Ser Phe 
            20                  25                  30          


Cys Phe His Leu Tyr Ile Ile Lys Asn Cys Ser Val Gly Gly Phe Arg 
        35                  40                  45              


Phe Ser Val Phe Leu Ile Leu Ser Leu Pro Ala Ala Ile His Ile Asn 
    50                  55                  60                  


Pro Glu Asp Trp Glu Gly Ile Ile His Thr Arg Arg Gln Gly Ala Leu 
65                  70                  75                  80  


Gly Ala Leu Leu Gly Leu Pro Ile Thr Ala Ser Leu Lys Val Phe Thr 
                85                  90                  95      


Leu Leu Gly 
            


<210>  4778
<211>  513
<212>  DNA
<213>  Homosapiens

<400>  4778
atggaggtag gaggctggaa aaaggacttt atggtccata ctggtgtgga gcactcggta     60

gtaaatcaag caatttggct attgtctaaa aattatgtca atataattgg agctacagga    120

ataacagaaa agaggcctta tttcaaatct aaaatatgtg tccaacatga atttttatat    180

ttgccaaatt gtctggtgcc cttgttagga agagatttgc tccagaaatt gcaagcacaa    240

atctccttta cactagaagg ggacatgact ctaaacctag gtcaaagaaa agccatcata    300

atgacgctta ctgtcccaac aacagaggaa tggagactct atgagagatg caaaatttgt    360

aaagatgcat tttgccagtg ggaaaatgag gcaatgtata aggaattatt tctcaagctg    420

ccaggggtct tggtggaaga caatcccccg gggctagcca taaatcaggc acccgtagtg    480

gtggaactgc tgtggggcac ttacccagtg tga                                 513


<210>  4779
<211>  170
<212>  PRT
<213>  Homosapiens

<400>  4779

Met Glu Val Gly Gly Trp Lys Lys Asp Phe Met Val His Thr Gly Val 
1               5                   10                  15      


Glu His Ser Val Val Asn Gln Ala Ile Trp Leu Leu Ser Lys Asn Tyr 
            20                  25                  30          


Val Asn Ile Ile Gly Ala Thr Gly Ile Thr Glu Lys Arg Pro Tyr Phe 
        35                  40                  45              


Lys Ser Lys Ile Cys Val Gln His Glu Phe Leu Tyr Leu Pro Asn Cys 
    50                  55                  60                  


Leu Val Pro Leu Leu Gly Arg Asp Leu Leu Gln Lys Leu Gln Ala Gln 
65                  70                  75                  80  


Ile Ser Phe Thr Leu Glu Gly Asp Met Thr Leu Asn Leu Gly Gln Arg 
                85                  90                  95      


Lys Ala Ile Ile Met Thr Leu Thr Val Pro Thr Thr Glu Glu Trp Arg 
            100                 105                 110         


Leu Tyr Glu Arg Cys Lys Ile Cys Lys Asp Ala Phe Cys Gln Trp Glu 
        115                 120                 125             


Asn Glu Ala Met Tyr Lys Glu Leu Phe Leu Lys Leu Pro Gly Val Leu 
    130                 135                 140                 


Val Glu Asp Asn Pro Pro Gly Leu Ala Ile Asn Gln Ala Pro Val Val 
145                 150                 155                 160 


Val Glu Leu Leu Trp Gly Thr Tyr Pro Val 
                165                 170 


<210>  4780
<211>  429
<212>  DNA
<213>  Homosapiens

<400>  4780
tgccttgggt ctcatgtccc actgcattgt catcttgaag atttgtcaca ctttgagaga     60

aaaacttgtt gccatgacaa tgggctcaga ggctgaaaag aagacttcaa ccactgtcag    120

cagcatcatt gtggtggcca agtggatcat ccccagagta gatgatgttg tgaaatcagt    180

gtaccatctg ttaagcacca agctcctgga tgctccatca gcagagagca gagaagagaa    240

gcaactggat atccaagaga agcagcttga cttcaaagag acaacttgac aacgtggctt    300

cagagaggag tctggccaag gactgctgaa ctccagggga ggattgccct cccactccat    360

ctgctttcca gctcccctcc ccacagagag ccattttcat cagcaataaa atcctccaca    420

ttcaccacc                                                            429


<210>  4781
<211>  71
<212>  PRT
<213>  Homosapiens

<400>  4781

Met Thr Met Gly Ser Glu Ala Glu Lys Lys Thr Ser Thr Thr Val Ser 
1               5                   10                  15      


Ser Ile Ile Val Val Ala Lys Trp Ile Ile Pro Arg Val Asp Asp Val 
            20                  25                  30          


Val Lys Ser Val Tyr His Leu Leu Ser Thr Lys Leu Leu Asp Ala Pro 
        35                  40                  45              


Ser Ala Glu Ser Arg Glu Glu Lys Gln Leu Asp Ile Gln Glu Lys Gln 
    50                  55                  60                  


Leu Asp Phe Lys Glu Thr Thr 
65                  70      


<210>  4782
<211>  551
<212>  DNA
<213>  Homosapiens

<400>  4782
gaaaggaacg atgtggacct gacctcaaag aaatccattg gagaatatga cagatttaga     60

tttaatgatc aactttactt ttcctataca gatgggaaaa cagcctgcaa aaatgttaag    120

tagcttcctc aggatcaagt actattggag ccagcattgg tggtcaatcc tgtatagaaa    180

tgacttcagt tgtagatctg tgaccttcct tacttacctt cctctaccaa agtgggtcaa    240

ccaaaaccgc atggcgtact actctctgaa gcctctacta ccctgctcct ccgtgttgac    300

atgtggtcag gcaagccagg acttactcac atcagctaca tcagttactg ggatggagaa    360

aattgaagcc tagaaagatc aagaaacttt ctccaggcca taaatagagg aatcaggatt    420

caaatcagat agaccccagg gcttgttctc ttcaacacca cattacccta cattattatt    480

caattattaa ataaaacctt gcattagtgg catttccaaa tgcataacaa aaaaataaaa    540

aaaagtaaca c                                                         551


<210>  4783
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  4783

Met Thr Asp Leu Asp Leu Met Ile Asn Phe Thr Phe Pro Ile Gln Met 
1               5                   10                  15      


Gly Lys Gln Pro Ala Lys Met Leu Ser Ser Phe Leu Arg Ile Lys Tyr 
            20                  25                  30          


Tyr Trp Ser Gln His Trp Trp Ser Ile Leu Tyr Arg Asn Asp Phe Ser 
        35                  40                  45              


Cys Arg Ser Val Thr Phe Leu Thr Tyr Leu Pro Leu Pro Lys Trp Val 
    50                  55                  60                  


Asn Gln Asn Arg Met Ala Tyr Tyr Ser Leu Lys Pro Leu Leu Pro Cys 
65                  70                  75                  80  


Ser Ser Val Leu Thr Cys Gly Gln Ala Ser Gln Asp Leu Leu Thr Ser 
                85                  90                  95      


Ala Thr Ser Val Thr Gly Met Glu Lys Ile Glu Ala 
            100                 105             


<210>  4784
<211>  551
<212>  DNA
<213>  Homosapiens

<400>  4784
gaaaggaacg atgtggacct gacctcaaag aaatccattg gagaatatga cagatttaga     60

tttaatgatc aactttactt ttcctataca gatgggaaaa cagcctgcaa aaatgttaag    120

tagcttcctc aggatcaagt actattggag ccagcattgg tggtcaatcc tgtatagaaa    180

tgacttcagt tgtagatctg tgaccttcct tacttacctt cctctaccaa agtgggtcaa    240

ccaaaaccgc atggcgtact actctctgaa gcctctacta ccctgctcct ccgtgttgac    300

atgtggtcag gcaagccagg acttactcac atcagctaca tcagttactg ggatggagaa    360

aattgaagcc tagaaagatc aagaaacttt ctccaggcca taaatagagg aatcaggatt    420

caaatcagat agaccccagg gcttgttctc ttcaacacca cattacccta cattattatt    480

caattattaa ataaaacctt gcattagtgg catttccaaa tgcataacaa aaaaataaaa    540

aaaagtaaca c                                                         551


<210>  4785
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  4785

Met Thr Asp Leu Asp Leu Met Ile Asn Phe Thr Phe Pro Ile Gln Met 
1               5                   10                  15      


Gly Lys Gln Pro Ala Lys Met Leu Ser Ser Phe Leu Arg Ile Lys Tyr 
            20                  25                  30          


Tyr Trp Ser Gln His Trp Trp Ser Ile Leu Tyr Arg Asn Asp Phe Ser 
        35                  40                  45              


Cys Arg Ser Val Thr Phe Leu Thr Tyr Leu Pro Leu Pro Lys Trp Val 
    50                  55                  60                  


Asn Gln Asn Arg Met Ala Tyr Tyr Ser Leu Lys Pro Leu Leu Pro Cys 
65                  70                  75                  80  


Ser Ser Val Leu Thr Cys Gly Gln Ala Ser Gln Asp Leu Leu Thr Ser 
                85                  90                  95      


Ala Thr Ser Val Thr Gly Met Glu Lys Ile Glu Ala 
            100                 105             


<210>  4786
<211>  471
<212>  DNA
<213>  Homosapiens

<400>  4786
atggctgagt ttgtctttgg tcaaaagggg aggatgataa gtgaaaaaac cctgcctgaa     60

aactttcatg atccaatggt gtttcacatg gaagaggacc aggaggagct catctttggg    120

catggtgaca cataccttca ctgcattgag gtgcacagcc acacccttat tcagctggag    180

agttggttca cagctacagg ccagactcat gtgactgtag ttggaccaca tagggcaagg    240

cagtggctgc tgcacatgtt ctattatgtg gggagccagg actcctgtcg tcacaatcaa    300

ggcctcaaga tgctggagcg tgtccggagc cagcccctga ccaaccatga tctggtcgcc    360

tccattagtg tgccaccgta caccagagac ctgtctttgg cctccaggat aagtggaacc    420

gtctgtctta gcgtacctca gcctttccct taccaagtga ttggtcgtta g             471


<210>  4787
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  4787

Met Ala Glu Phe Val Phe Gly Gln Lys Gly Arg Met Ile Ser Glu Lys 
1               5                   10                  15      


Thr Leu Pro Glu Asn Phe His Asp Pro Met Val Phe His Met Glu Glu 
            20                  25                  30          


Asp Gln Glu Glu Leu Ile Phe Gly His Gly Asp Thr Tyr Leu His Cys 
        35                  40                  45              


Ile Glu Val His Ser His Thr Leu Ile Gln Leu Glu Ser Trp Phe Thr 
    50                  55                  60                  


Ala Thr Gly Gln Thr His Val Thr Val Val Gly Pro His Arg Ala Arg 
65                  70                  75                  80  


Gln Trp Leu Leu His Met Phe Tyr Tyr Val Gly Ser Gln Asp Ser Cys 
                85                  90                  95      


Arg His Asn Gln Gly Leu Lys Met Leu Glu Arg Val Arg Ser Gln Pro 
            100                 105                 110         


Leu Thr Asn His Asp Leu Val Ala Ser Ile Ser Val Pro Pro Tyr Thr 
        115                 120                 125             


Arg Asp Leu Ser Leu Ala Ser Arg Ile Ser Gly Thr Val Cys Leu Ser 
    130                 135                 140                 


Val Pro Gln Pro Phe Pro Tyr Gln Val Ile Gly Arg 
145                 150                 155     


<210>  4788
<211>  3304
<212>  DNA
<213>  Homosapiens

<400>  4788
ctataatttt aattatagct gtaaagtccc ttttcctata taatatattc aaaggttgca     60

ggcatttggg tgttgacatc tttgatgggc acattgtgtc taccacaggc tatagaaaga    120

acagagaaat ttgtccaaga taagatgatt aggttttgtc tagatagggg cccttgctat    180

gggccctcag tttttacctt aatgtaacag aacatgagag gagctttgac acccacccca    240

aaagagtcaa cttcattatg ctggcaaagg catgggtaca acctgctctg tgatctacct    300

tctgaaccac acaagcttgt cctgaacgag gttggggctg agtctgttga taacagaccc    360

ccatttttgg gcagaaaaaa cagattctgt atgatctaca gtatttaaca ttgtggcaaa    420

taaattataa aggaaaaatg gaatctcaag tagttacagt ctcttggtgt ctttcaacat    480

tggttttatt ttgaagtcat tttcacccag cattgcaagt ttagcagacc tcaaaacaga    540

atgccaaagt gatcttaaaa ttcaaaaatg agtttacttt ctttgttaaa gttctctttt    600

gatgcatatc ccccattcat ggaatggaag cattatcttg ggtgcagcat tacacgtaga    660

gttaaaatgt ggaaacaacc caaacatcct gatatggttt ggctctgtgt caccacccaa    720

atctcatctt gaattgtact ctcataattc ccatgtgttg tgggaggaac ccagtgggag    780

ataatttgaa tcatgggggc agtttccctc atactgttct catggtagtg aataactctc    840

acaagacctg gtggttttat caggggtttc cgcttttgca tcttactcat tttctcttgc    900

ggccgccatg taagaagtgc ctttcacctc ctgccatgat tctgaggcct ccccagccat    960

gtggaactgt aagtccaatt aaaccccttt ttttccccag tctcaggtac gtcttttatc   1020

agcagcgtga aaatggacta atacagtaaa ttggtaccag tagagcaggt gttgctgcaa   1080

agataccggg aaatgtggaa gcaactttgg aacttggtaa caggcagaga ttggaacagt   1140

ttggagggct cagaagaaga caggaaaatg ggaaagtttg gaacttcctt gagacttgtt   1200

gaatggcttt gacaaaaata ctgataatga tatggacaat gaaatctaga ctgaggtggt   1260

ctcaggtgga gatgaggaac ctgttgagaa ctggagcaaa ggtgactctt gttatgattt   1320

agcaaagaga ctggcggcat tttgcccctg ccctggagat ttgtggaact ctgaacttga   1380

gagagatgat taagggtatc tggtggaaga aatttctaag cagcaaagca ttcaagaggt   1440

gactcaagtg ttgttaaagg cattcagttt taaaagggaa gcagagcatt aaaattcaga   1500

aaattagcag cttgacaatg cgatagaaaa gaaaatccta ttttctgagg agaaattcaa   1560

gctggctgta gatatttgca taagtaacaa ggaactgaat gttaatttcc aagacaatgg   1620

ggaaaatgtc tccagggcat gtcagagaca tttgtggcag cctcttctat cacagacctg   1680

gaggtctagg aagaaaaaat ggtaaaaatg gttttgtggg caaggcctag ggtccttgtg   1740

ctgtgtgcag tctaaggact tggtgccctg tttcctagcc actccggcca tggctgaaag   1800

gggccaacat gaagctcagg ccatggcttc agagggtgaa agccttaagc cttggcaact   1860

tccatgtgat gttgagcatg tgggtgcaca gaagtcaaga aatggggttt gggaacctct   1920

gtctagattt cagaagatgt atggaaatgc ctggatgccc aggcagaagt ttgctgcagg   1980

ggcggggctc tcatggagaa cctcggctag ggcagtgcag aagggaaatg tggggttgga   2040

gccccctcac agagtcccta ctgggacacc gcctagtgga gctgtgagaa gaggaccact   2100

gtcctccaga ccccagaatg gtagatcgac ttacagcttg taccaggtgc ctggaaaagc   2160

tgcagatact caacaccagc ccatgaaagc agccaggatg gaggctgtac cctgaaagcc   2220

acagggccag agctgcccaa gaccatggga agccacctct tgcatcagcg tgacctggat   2280

gtgagacctg gagtaaaagg agatcatttt ggagctttaa aatttgactg ccccactgga   2340

ttttggactt ccatgggccc tgtaacccct ttgttttggc caatttctcc catttggaat   2400

ggctgtattt acccaatacc tgtaccctca ttgtatctag gaagtaacta gcttgctttt   2460

gattttacag gctcataagt ggaagggact tgccttgtct cagatgagac ttttgaactg   2520

tggacttttg ggttaatgct gaaatgattt aagactttgg ggtactgttg ggaatgcatg   2580

attggttttg aaatgtgagg acataagatt tggaggagcc aggggtggga tgatatggtt   2640

tggctctgtg tccccaccca aatttcatct tgaattatac tcccataatt cccatgtgtt   2700

atacgtggga cctggtggga gataatttga atcatggggg tggtttcccc catactgttc   2760

tcatggtaga gaataagtct catgagatct gatggtttca tcagggggtt ccgcttttgc   2820

atcttactca tttctcttgc tgccaccctg taagaagtat ttttaaccta ccgccatgat   2880

tctgaggcct ccccagccat gtggaactat aagtccaatt aaacctcttt ttcttggctt   2940

aatttcttgg gtatgtcttt atcagcagtg attctattcc tatgaaatgt ctagaacagg   3000

aaaatctatg agacataaag taattaagtg gctgttcagg ggatacagga ataggggata   3060

ataactaaag ggttgggagg gtgtttttga aatgctaaaa tattctgaag tttactgtgg   3120

ttatggttgc acatacttat gaatatacct aaaaatgttg aattgtacat tttaagtaga   3180

tgaattgtat ctaatttgaa ccatatctca gtaaagatat aaaaatgttt ttgggtacta   3240

agactaaact agaaagaaca taagaggaaa tacatattat ataagaagaa aagagtaaaa   3300

ataa                                                                3304


<210>  4789
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  4789

Met Ala Glu Arg Gly Gln His Glu Ala Gln Ala Met Ala Ser Glu Gly 
1               5                   10                  15      


Glu Ser Leu Lys Pro Trp Gln Leu Pro Cys Asp Val Glu His Val Gly 
            20                  25                  30          


Ala Gln Lys Ser Arg Asn Gly Val Trp Glu Pro Leu Ser Arg Phe Gln 
        35                  40                  45              


Lys Met Tyr Gly Asn Ala Trp Met Pro Arg Gln Lys Phe Ala Ala Gly 
    50                  55                  60                  


Ala Gly Leu Ser Trp Arg Thr Ser Ala Arg Ala Val Gln Lys Gly Asn 
65                  70                  75                  80  


Val Gly Leu Glu Pro Pro His Arg Val Pro Thr Gly Thr Pro Pro Ser 
                85                  90                  95      


Gly Ala Val Arg Arg Gly Pro Leu Ser Ser Arg Pro Gln Asn Gly Arg 
            100                 105                 110         


Ser Thr Tyr Ser Leu Tyr Gln Val Pro Gly Lys Ala Ala Asp Thr Gln 
        115                 120                 125             


His Gln Pro Met Lys Ala Ala Arg Met Glu Ala Val Pro 
    130                 135                 140     


<210>  4790
<211>  3304
<212>  DNA
<213>  Homosapiens

<400>  4790
ctataatttt aattatagct gtaaagtccc ttttcctata taatatattc aaaggttgca     60

ggcatttggg tgttgacatc tttgatgggc acattgtgtc taccacaggc tatagaaaga    120

acagagaaat ttgtccaaga taagatgatt aggttttgtc tagatagggg cccttgctat    180

gggccctcag tttttacctt aatgtaacag aacatgagag gagctttgac acccacccca    240

aaagagtcaa cttcattatg ctggcaaagg catgggtaca acctgctctg tgatctacct    300

tctgaaccac acaagcttgt cctgaacgag gttggggctg agtctgttga taacagaccc    360

ccatttttgg gcagaaaaaa cagattctgt atgatctaca gtatttaaca ttgtggcaaa    420

taaattataa aggaaaaatg gaatctcaag tagttacagt ctcttggtgt ctttcaacat    480

tggttttatt ttgaagtcat tttcacccag cattgcaagt ttagcagacc tcaaaacaga    540

atgccaaagt gatcttaaaa ttcaaaaatg agtttacttt ctttgttaaa gttctctttt    600

gatgcatatc ccccattcat ggaatggaag cattatcttg ggtgcagcat tacacgtaga    660

gttaaaatgt ggaaacaacc caaacatcct gatatggttt ggctctgtgt caccacccaa    720

atctcatctt gaattgtact ctcataattc ccatgtgttg tgggaggaac ccagtgggag    780

ataatttgaa tcatgggggc agtttccctc atactgttct catggtagtg aataactctc    840

acaagacctg gtggttttat caggggtttc cgcttttgca tcttactcat tttctcttgc    900

ggccgccatg taagaagtgc ctttcacctc ctgccatgat tctgaggcct ccccagccat    960

gtggaactgt aagtccaatt aaaccccttt ttttccccag tctcaggtac gtcttttatc   1020

agcagcgtga aaatggacta atacagtaaa ttggtaccag tagagcaggt gttgctgcaa   1080

agataccggg aaatgtggaa gcaactttgg aacttggtaa caggcagaga ttggaacagt   1140

ttggagggct cagaagaaga caggaaaatg ggaaagtttg gaacttcctt gagacttgtt   1200

gaatggcttt gacaaaaata ctgataatga tatggacaat gaaatctaga ctgaggtggt   1260

ctcaggtgga gatgaggaac ctgttgagaa ctggagcaaa ggtgactctt gttatgattt   1320

agcaaagaga ctggcggcat tttgcccctg ccctggagat ttgtggaact ctgaacttga   1380

gagagatgat taagggtatc tggtggaaga aatttctaag cagcaaagca ttcaagaggt   1440

gactcaagtg ttgttaaagg cattcagttt taaaagggaa gcagagcatt aaaattcaga   1500

aaattagcag cttgacaatg cgatagaaaa gaaaatccta ttttctgagg agaaattcaa   1560

gctggctgta gatatttgca taagtaacaa ggaactgaat gttaatttcc aagacaatgg   1620

ggaaaatgtc tccagggcat gtcagagaca tttgtggcag cctcttctat cacagacctg   1680

gaggtctagg aagaaaaaat ggtaaaaatg gttttgtggg caaggcctag ggtccttgtg   1740

ctgtgtgcag tctaaggact tggtgccctg tttcctagcc actccggcca tggctgaaag   1800

gggccaacat gaagctcagg ccatggcttc agagggtgaa agccttaagc cttggcaact   1860

tccatgtgat gttgagcatg tgggtgcaca gaagtcaaga aatggggttt gggaacctct   1920

gtctagattt cagaagatgt atggaaatgc ctggatgccc aggcagaagt ttgctgcagg   1980

ggcggggctc tcatggagaa cctcggctag ggcagtgcag aagggaaatg tggggttgga   2040

gccccctcac agagtcccta ctgggacacc gcctagtgga gctgtgagaa gaggaccact   2100

gtcctccaga ccccagaatg gtagatcgac ttacagcttg taccaggtgc ctggaaaagc   2160

tgcagatact caacaccagc ccatgaaagc agccaggatg gaggctgtac cctgaaagcc   2220

acagggccag agctgcccaa gaccatggga agccacctct tgcatcagcg tgacctggat   2280

gtgagacctg gagtaaaagg agatcatttt ggagctttaa aatttgactg ccccactgga   2340

ttttggactt ccatgggccc tgtaacccct ttgttttggc caatttctcc catttggaat   2400

ggctgtattt acccaatacc tgtaccctca ttgtatctag gaagtaacta gcttgctttt   2460

gattttacag gctcataagt ggaagggact tgccttgtct cagatgagac ttttgaactg   2520

tggacttttg ggttaatgct gaaatgattt aagactttgg ggtactgttg ggaatgcatg   2580

attggttttg aaatgtgagg acataagatt tggaggagcc aggggtggga tgatatggtt   2640

tggctctgtg tccccaccca aatttcatct tgaattatac tcccataatt cccatgtgtt   2700

atacgtggga cctggtggga gataatttga atcatggggg tggtttcccc catactgttc   2760

tcatggtaga gaataagtct catgagatct gatggtttca tcagggggtt ccgcttttgc   2820

atcttactca tttctcttgc tgccaccctg taagaagtat ttttaaccta ccgccatgat   2880

tctgaggcct ccccagccat gtggaactat aagtccaatt aaacctcttt ttcttggctt   2940

aatttcttgg gtatgtcttt atcagcagtg attctattcc tatgaaatgt ctagaacagg   3000

aaaatctatg agacataaag taattaagtg gctgttcagg ggatacagga ataggggata   3060

ataactaaag ggttgggagg gtgtttttga aatgctaaaa tattctgaag tttactgtgg   3120

ttatggttgc acatacttat gaatatacct aaaaatgttg aattgtacat tttaagtaga   3180

tgaattgtat ctaatttgaa ccatatctca gtaaagatat aaaaatgttt ttgggtacta   3240

agactaaact agaaagaaca taagaggaaa tacatattat ataagaagaa aagagtaaaa   3300

ataa                                                                3304


<210>  4791
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  4791

Met Ala Glu Arg Gly Gln His Glu Ala Gln Ala Met Ala Ser Glu Gly 
1               5                   10                  15      


Glu Ser Leu Lys Pro Trp Gln Leu Pro Cys Asp Val Glu His Val Gly 
            20                  25                  30          


Ala Gln Lys Ser Arg Asn Gly Val Trp Glu Pro Leu Ser Arg Phe Gln 
        35                  40                  45              


Lys Met Tyr Gly Asn Ala Trp Met Pro Arg Gln Lys Phe Ala Ala Gly 
    50                  55                  60                  


Ala Gly Leu Ser Trp Arg Thr Ser Ala Arg Ala Val Gln Lys Gly Asn 
65                  70                  75                  80  


Val Gly Leu Glu Pro Pro His Arg Val Pro Thr Gly Thr Pro Pro Ser 
                85                  90                  95      


Gly Ala Val Arg Arg Gly Pro Leu Ser Ser Arg Pro Gln Asn Gly Arg 
            100                 105                 110         


Ser Thr Tyr Ser Leu Tyr Gln Val Pro Gly Lys Ala Ala Asp Thr Gln 
        115                 120                 125             


His Gln Pro Met Lys Ala Ala Arg Met Glu Ala Val Pro 
    130                 135                 140     


<210>  4792
<211>  1423
<212>  DNA
<213>  Homosapiens

<400>  4792
atgccagaat ctcctaaagc taagataagt gcggtcaaag agagggaatc cgaacccaag     60

aaaatgagca cccccacccc caccgggcca tgcctaaaac tgagctgtct tccagcaaac    120

ccggcgccgt cctttcggga agccgcgatg gcaaacgtcg ccctgggcct tcggaggatc    180

aagaaaaaac gtcggcgaga aagggctgga cgcaaggctg ggggcgattt tcgggatctc    240

tctctgcccc tggcaagatc tctcccgcct gaaagccgcc gacccgcccg tcgggcaaac    300

tgtcctgatt ccttccgccg cgttttggta aaccacttgg cgcaaaaacg atccccgacg    360

cctgcccggt acaaagcagt tcggcttgcg gagcgcgaaa gggaggtgcg cacgccctct    420

ggcggcgcgg cccccggcag caccggggca ataaatcagg gccggcgaag gaaagacgcg    480

gcgcgccggc ttccgaaccg caacttgctg cgagacctgt cacttccccg cggtgcccag    540

tcctcgcccc tccctggcgc tcgcgcctcc tcttttcttc ctgctcctca gcacggagct    600

cccctcgacg ttgctcacgt gccagactcg ggaccgcgag cggcgtccgc acccgcacgc    660

acacccggcc acgctcgcac tcgcgcggcc gcggggccgg ctgcttacct ccggggcctc    720

atggtcgcgt cgctagcctg ggtccggcgg cacgcgcaca cctgcccgcc gccgctaccg    780

gccgcgtcat tggctgccgg cgccgagcgc gcgagattga accttccatt cattccaggg    840

ccgggcgggc gagcgcggcc gcggtggagc tttaccgcgg gcgcccccga acccccgaag    900

cgcgtccccg cgcaggccgt gggcgcgcac ggccgctgcc gccgtttgtt ctggtggagg    960

ctgcgagtgc ctgggcctgt gactcccggc tctccgcgcg cagcatgccc tggacatcat   1020

tccgaacagc acaattcaag ggtggctgaa acaacaaaaa tgtaacgtct tacagatctg   1080

aaggcttccg ggtcgattct ggactgtgat gagaatctgt gccaagcctc tctcctggct   1140

tctggtagac tcgggcattc cttagcttgt aaatggctgc tgcttgtgtc atcacattgt   1200

cttccctttc tacttatctg tccccatgcc ccaatttttc cttttcagga caccagtcag   1260

attaggaccc accctaatga tctcatctta acttgattaa ctacaaggac cctattttta   1320

agtacacatt tacagagact ggggggtagg acttcaacat ctttttggag ggatgcagtt   1380

caacccataa caagaatcat tgttagaaat gattttgctt ctt                     1423


<210>  4793
<211>  354
<212>  PRT
<213>  Homosapiens

<400>  4793

Met Pro Glu Ser Pro Lys Ala Lys Ile Ser Ala Val Lys Glu Arg Glu 
1               5                   10                  15      


Ser Glu Pro Lys Lys Met Ser Thr Pro Thr Pro Thr Gly Pro Cys Leu 
            20                  25                  30          


Lys Leu Ser Cys Leu Pro Ala Asn Pro Ala Pro Ser Phe Arg Glu Ala 
        35                  40                  45              


Ala Met Ala Asn Val Ala Leu Gly Leu Arg Arg Ile Lys Lys Lys Arg 
    50                  55                  60                  


Arg Arg Glu Arg Ala Gly Arg Lys Ala Gly Gly Asp Phe Arg Asp Leu 
65                  70                  75                  80  


Ser Leu Pro Leu Ala Arg Ser Leu Pro Pro Glu Ser Arg Arg Pro Ala 
                85                  90                  95      


Arg Arg Ala Asn Cys Pro Asp Ser Phe Arg Arg Val Leu Val Asn His 
            100                 105                 110         


Leu Ala Gln Lys Arg Ser Pro Thr Pro Ala Arg Tyr Lys Ala Val Arg 
        115                 120                 125             


Leu Ala Glu Arg Glu Arg Glu Val Arg Thr Pro Ser Gly Gly Ala Ala 
    130                 135                 140                 


Pro Gly Ser Thr Gly Ala Ile Asn Gln Gly Arg Arg Arg Lys Asp Ala 
145                 150                 155                 160 


Ala Arg Arg Leu Pro Asn Arg Asn Leu Leu Arg Asp Leu Ser Leu Pro 
                165                 170                 175     


Arg Gly Ala Gln Ser Ser Pro Leu Pro Gly Ala Arg Ala Ser Ser Phe 
            180                 185                 190         


Leu Pro Ala Pro Gln His Gly Ala Pro Leu Asp Val Ala His Val Pro 
        195                 200                 205             


Asp Ser Gly Pro Arg Ala Ala Ser Ala Pro Ala Arg Thr Pro Gly His 
    210                 215                 220                 


Ala Arg Thr Arg Ala Ala Ala Gly Pro Ala Ala Tyr Leu Arg Gly Leu 
225                 230                 235                 240 


Met Val Ala Ser Leu Ala Trp Val Arg Arg His Ala His Thr Cys Pro 
                245                 250                 255     


Pro Pro Leu Pro Ala Ala Ser Leu Ala Ala Gly Ala Glu Arg Ala Arg 
            260                 265                 270         


Leu Asn Leu Pro Phe Ile Pro Gly Pro Gly Gly Arg Ala Arg Pro Arg 
        275                 280                 285             


Trp Ser Phe Thr Ala Gly Ala Pro Glu Pro Pro Lys Arg Val Pro Ala 
    290                 295                 300                 


Gln Ala Val Gly Ala His Gly Arg Cys Arg Arg Leu Phe Trp Trp Arg 
305                 310                 315                 320 


Leu Arg Val Pro Gly Pro Val Thr Pro Gly Ser Pro Arg Ala Ala Cys 
                325                 330                 335     


Pro Gly His His Ser Glu Gln His Asn Ser Arg Val Ala Glu Thr Thr 
            340                 345                 350         


Lys Met 
        


<210>  4794
<211>  1423
<212>  DNA
<213>  Homosapiens

<400>  4794
atgccagaat ctcctaaagc taagataagt gcggtcaaag agagggaatc cgaacccaag     60

aaaatgagca cccccacccc caccgggcca tgcctaaaac tgagctgtct tccagcaaac    120

ccggcgccgt cctttcggga agccgcgatg gcaaacgtcg ccctgggcct tcggaggatc    180

aagaaaaaac gtcggcgaga aagggctgga cgcaaggctg ggggcgattt tcgggatctc    240

tctctgcccc tggcaagatc tctcccgcct gaaagccgcc gacccgcccg tcgggcaaac    300

tgtcctgatt ccttccgccg cgttttggta aaccacttgg cgcaaaaacg atccccgacg    360

cctgcccggt acaaagcagt tcggcttgcg gagcgcgaaa gggaggtgcg cacgccctct    420

ggcggcgcgg cccccggcag caccggggca ataaatcagg gccggcgaag gaaagacgcg    480

gcgcgccggc tcccgaaccg caacttgctg cgagacctgt cacttccccg cggtgcccag    540

tcctcgcccc tccctggcgc tcgcgcctcc tcttttcttc ctgctcctca gcacggagct    600

cccctcgacg ttgctcacgt gccagactcg ggaccgcgag cggcgtccgc acccgcacgc    660

acacccggcc acgctcgcac tcgcgcggcc gcggggccgg ctgcttacct ccggggcctc    720

atggtcgcgt cgctagcctg ggtccggcgg cacgcgcaca cctgcccgcc gccgctaccg    780

gccgcgtcat tggctgccgg cgccgagcgc gcgagattga accttccatt cattccaggg    840

ccgggcgggc gcgcgcggcc gcggtggagc tttaccgcgg gcgcccccga acccccgaag    900

cgcgtccccg cgcaggccgt gggcgcgcac ggccgctgcc gccgtttgtt ctggtggagg    960

ctgcgagtgc ctgggcctgt gactcccggc tctccgcgcg cagcatgccc tggacatcat   1020

tccgaacagc acaattcaag ggtggctgaa acaacaaaaa tgtaacgtct tacagatctg   1080

aaggcttccg ggtcgattct ggactgtgat gagaatctgt gccaagcctc tctcctggct   1140

tctggtagac tcgggcattc cttagcttgt aaatggctgc tgcttgtgtc atcacattgt   1200

cttccctttc tacttatctg tccccatgcc ccaatttttc cttttcagga caccagtcag   1260

attaggaccc accctaatga tctcatctta acttgattaa ctacaaggac cctattttta   1320

agtacacatt tacagagact ggggggtagg acttcaacat ctttttggag ggatgcagtt   1380

caacccataa caagaatcat tgttagaaat gattttgctt ctt                     1423


<210>  4795
<211>  354
<212>  PRT
<213>  Homosapiens

<400>  4795

Met Pro Glu Ser Pro Lys Ala Lys Ile Ser Ala Val Lys Glu Arg Glu 
1               5                   10                  15      


Ser Glu Pro Lys Lys Met Ser Thr Pro Thr Pro Thr Gly Pro Cys Leu 
            20                  25                  30          


Lys Leu Ser Cys Leu Pro Ala Asn Pro Ala Pro Ser Phe Arg Glu Ala 
        35                  40                  45              


Ala Met Ala Asn Val Ala Leu Gly Leu Arg Arg Ile Lys Lys Lys Arg 
    50                  55                  60                  


Arg Arg Glu Arg Ala Gly Arg Lys Ala Gly Gly Asp Phe Arg Asp Leu 
65                  70                  75                  80  


Ser Leu Pro Leu Ala Arg Ser Leu Pro Pro Glu Ser Arg Arg Pro Ala 
                85                  90                  95      


Arg Arg Ala Asn Cys Pro Asp Ser Phe Arg Arg Val Leu Val Asn His 
            100                 105                 110         


Leu Ala Gln Lys Arg Ser Pro Thr Pro Ala Arg Tyr Lys Ala Val Arg 
        115                 120                 125             


Leu Ala Glu Arg Glu Arg Glu Val Arg Thr Pro Ser Gly Gly Ala Ala 
    130                 135                 140                 


Pro Gly Ser Thr Gly Ala Ile Asn Gln Gly Arg Arg Arg Lys Asp Ala 
145                 150                 155                 160 


Ala Arg Arg Leu Pro Asn Arg Asn Leu Leu Arg Asp Leu Ser Leu Pro 
                165                 170                 175     


Arg Gly Ala Gln Ser Ser Pro Leu Pro Gly Ala Arg Ala Ser Ser Phe 
            180                 185                 190         


Leu Pro Ala Pro Gln His Gly Ala Pro Leu Asp Val Ala His Val Pro 
        195                 200                 205             


Asp Ser Gly Pro Arg Ala Ala Ser Ala Pro Ala Arg Thr Pro Gly His 
    210                 215                 220                 


Ala Arg Thr Arg Ala Ala Ala Gly Pro Ala Ala Tyr Leu Arg Gly Leu 
225                 230                 235                 240 


Met Val Ala Ser Leu Ala Trp Val Arg Arg His Ala His Thr Cys Pro 
                245                 250                 255     


Pro Pro Leu Pro Ala Ala Ser Leu Ala Ala Gly Ala Glu Arg Ala Arg 
            260                 265                 270         


Leu Asn Leu Pro Phe Ile Pro Gly Pro Gly Gly Arg Ala Arg Pro Arg 
        275                 280                 285             


Trp Ser Phe Thr Ala Gly Ala Pro Glu Pro Pro Lys Arg Val Pro Ala 
    290                 295                 300                 


Gln Ala Val Gly Ala His Gly Arg Cys Arg Arg Leu Phe Trp Trp Arg 
305                 310                 315                 320 


Leu Arg Val Pro Gly Pro Val Thr Pro Gly Ser Pro Arg Ala Ala Cys 
                325                 330                 335     


Pro Gly His His Ser Glu Gln His Asn Ser Arg Val Ala Glu Thr Thr 
            340                 345                 350         


Lys Met 
        


<210>  4796
<211>  135
<212>  DNA
<213>  Homosapiens

<400>  4796
atggatgact ttgaggggtt tgagatttca gtggatgaag caactgaaga tgtggtagaa     60

atagcaagac aactaaaatt agaattggaa tgtgaagatg tgactgaatt actgcaatcc    120

tatgataaag cttga                                                     135


<210>  4797
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  4797

Met Asp Asp Phe Glu Gly Phe Glu Ile Ser Val Asp Glu Ala Thr Glu 
1               5                   10                  15      


Asp Val Val Glu Ile Ala Arg Gln Leu Lys Leu Glu Leu Glu Cys Glu 
            20                  25                  30          


Asp Val Thr Glu Leu Leu Gln Ser Tyr Asp Lys Ala 
        35                  40                  


<210>  4798
<211>  531
<212>  DNA
<213>  Homosapiens

<400>  4798
cggacgcgtg ggttcgaacg ttcggactga ggtttttctg cctgaagaag cgtcatacgg     60

accggattgt tttcgctggc ccagtgtccc cggagcttgt gtgcgataca gagagcacct    120

cggaagctga ggcagctggt acttgacaga gaggatggcg ctgtcgacca tagtctccca    180

gaggaagcag ataaagcgga aggctccccg tggctttcta aagcgagtct tcaagcgaaa    240

gaagcctcaa cttcgtctgg agaaaagtgg tgacttattg gtccatctga actgtttact    300

gtttgttcat cgattagcag aagagtccag gacaaacgct tgtgcgagta aatgtagagt    360

cattaacaag gagcatgtac tggccgcagc aaaggtaatt ctaaagaaga gcagaggtta    420

gaagtcaaag aacatattct tgaaagttat gatgcattct tttgggtggt aacagatcat    480

aaagacattt tttacacatc agttaatatg ggattattaa atattggcta t             531


<210>  4799
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  4799

Met Ala Leu Ser Thr Ile Val Ser Gln Arg Lys Gln Ile Lys Arg Lys 
1               5                   10                  15      


Ala Pro Arg Gly Phe Leu Lys Arg Val Phe Lys Arg Lys Lys Pro Gln 
            20                  25                  30          


Leu Arg Leu Glu Lys Ser Gly Asp Leu Leu Val His Leu Asn Cys Leu 
        35                  40                  45              


Leu Phe Val His Arg Leu Ala Glu Glu Ser Arg Thr Asn Ala Cys Ala 
    50                  55                  60                  


Ser Lys Cys Arg Val Ile Asn Lys Glu His Val Leu Ala Ala Ala Lys 
65                  70                  75                  80  


Val Ile Leu Lys Lys Ser Arg Gly 
                85              


<210>  4800
<211>  234
<212>  DNA
<213>  Homosapiens

<400>  4800
atgaaacaag caaagatctg tcatgatgaa cttaaaattg aagggaacta taaatattta     60

atagaatggt tgaagaaatt tcagaaggga tgtggcatta aatttttcag gatttctggt    120

tataaaacgt ctgttgatca tgaagtagtg gagaaattca ctgacgagtt tgcaaaggtc    180

attgctgatg aaaatctgat gccagaccaa ctctataatg ctgacaaaac ataa          234


<210>  4801
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  4801

Met Lys Gln Ala Lys Ile Cys His Asp Glu Leu Lys Ile Glu Gly Asn 
1               5                   10                  15      


Tyr Lys Tyr Leu Ile Glu Trp Leu Lys Lys Phe Gln Lys Gly Cys Gly 
            20                  25                  30          


Ile Lys Phe Phe Arg Ile Ser Gly Tyr Lys Thr Ser Val Asp His Glu 
        35                  40                  45              


Val Val Glu Lys Phe Thr Asp Glu Phe Ala Lys Val Ile Ala Asp Glu 
    50                  55                  60                  


Asn Leu Met Pro Asp Gln Leu Tyr Asn Ala Asp Lys Thr 
65                  70                  75          


<210>  4802
<211>  489
<212>  DNA
<213>  Homosapiens

<400>  4802
atggaggaac cactttctag agagattaac ataactaaaa ttgctaacat ccaaaacaat     60

gggaaaaggg ccttgaaggc atctcagaag gcttggagac agccccttcc atcccagacc    120

cagaggtcaa ggaggaaaga atggtttcag gggccaggcc caggaccctg ctgctgtgct    180

cagtctctgg acaccgctcc cccaatcttg gcctctctgg ctccagtctt ggctcaaagg    240

gcctcagatg cagctcaggc agccacttca gagagtgcaa accataaacc atggcagctt    300

ccatatggtg ttaagcttgc tggtatacag aatgcaagaa tgaagaaggc ttggcagctt    360

ccaccaagat ttcagaggat atatgggaaa gcacagatgt tcagacagaa gcctgcttca    420

gggatagatc ccatgcagag agcctctatg agggaagtgc tgagaagaaa tgtagggttg    480

gaaccctga                                                            489


<210>  4803
<211>  162
<212>  PRT
<213>  Homosapiens

<400>  4803

Met Glu Glu Pro Leu Ser Arg Glu Ile Asn Ile Thr Lys Ile Ala Asn 
1               5                   10                  15      


Ile Gln Asn Asn Gly Lys Arg Ala Leu Lys Ala Ser Gln Lys Ala Trp 
            20                  25                  30          


Arg Gln Pro Leu Pro Ser Gln Thr Gln Arg Ser Arg Arg Lys Glu Trp 
        35                  40                  45              


Phe Gln Gly Pro Gly Pro Gly Pro Cys Cys Cys Ala Gln Ser Leu Asp 
    50                  55                  60                  


Thr Ala Pro Pro Ile Leu Ala Ser Leu Ala Pro Val Leu Ala Gln Arg 
65                  70                  75                  80  


Ala Ser Asp Ala Ala Gln Ala Ala Thr Ser Glu Ser Ala Asn His Lys 
                85                  90                  95      


Pro Trp Gln Leu Pro Tyr Gly Val Lys Leu Ala Gly Ile Gln Asn Ala 
            100                 105                 110         


Arg Met Lys Lys Ala Trp Gln Leu Pro Pro Arg Phe Gln Arg Ile Tyr 
        115                 120                 125             


Gly Lys Ala Gln Met Phe Arg Gln Lys Pro Ala Ser Gly Ile Asp Pro 
    130                 135                 140                 


Met Gln Arg Ala Ser Met Arg Glu Val Leu Arg Arg Asn Val Gly Leu 
145                 150                 155                 160 


Glu Pro 
        


<210>  4804
<211>  801
<212>  DNA
<213>  Homosapiens

<400>  4804
atggaaaaat tctcctccat gaaactggtt cctggtgcca aaaaggttgg agactgcccc     60

acttcgggag cccccggtgc tccgggccca cctgactggg cgtcctctga gtcagggagg    120

tgccagtgct gtggtccccg cgagcccaac tgtcccctga cccccgggct tttccgcacc    180

gtggagtccc ccgacacgct ggggccagtg aacccgggcc ggggcgcgcg ttctccctcc    240

cggaccagct cccggcgctg ggcccgcggc cgagaaacta ggtctgggcc ggccctgcgg    300

cggccgccgg gcgcggcgag ccccactttc tcccggcagg aaggggggag gccgagagca    360

tttcctgttg tgcagctgag ccctgcggag acgtcattgc attcatgctc cctcgggtgt    420

cagcggacgg ggggccaaag ttcaagccgc gtccagggca ggcagcgcgc ggcggcgcgg    480

cggcgcgggg cgggcggcca gggctcccct ctcccgctgg cgctcccggc gcctccgtcc    540

ccggccggcc cagcgctgct accggaggcc agccctgggg ctccgcgggg aagagctgct    600

cttcctcccg gaggaaaccg agctcgcaag cccagcgctc ccagccgcag actgcaggct    660

gccctcctcc accgcctgga tttcccacgg ggaggaaaag gcgtgcgttt ccaggtgttt    720

ggaggacgca ctggccgggc gcactttcct cagcgtaatt ttgaacgcag tttccctaaa    780

gatgactctt ttttccacta g                                              801


<210>  4805
<211>  266
<212>  PRT
<213>  Homosapiens

<400>  4805

Met Glu Lys Phe Ser Ser Met Lys Leu Val Pro Gly Ala Lys Lys Val 
1               5                   10                  15      


Gly Asp Cys Pro Thr Ser Gly Ala Pro Gly Ala Pro Gly Pro Pro Asp 
            20                  25                  30          


Trp Ala Ser Ser Glu Ser Gly Arg Cys Gln Cys Cys Gly Pro Arg Glu 
        35                  40                  45              


Pro Asn Cys Pro Leu Thr Pro Gly Leu Phe Arg Thr Val Glu Ser Pro 
    50                  55                  60                  


Asp Thr Leu Gly Pro Val Asn Pro Gly Arg Gly Ala Arg Ser Pro Ser 
65                  70                  75                  80  


Arg Thr Ser Ser Arg Arg Trp Ala Arg Gly Arg Glu Thr Arg Ser Gly 
                85                  90                  95      


Pro Ala Leu Arg Arg Pro Pro Gly Ala Ala Ser Pro Thr Phe Ser Arg 
            100                 105                 110         


Gln Glu Gly Gly Arg Pro Arg Ala Phe Pro Val Val Gln Leu Ser Pro 
        115                 120                 125             


Ala Glu Thr Ser Leu His Ser Cys Ser Leu Gly Cys Gln Arg Thr Gly 
    130                 135                 140                 


Gly Gln Ser Ser Ser Arg Val Gln Gly Arg Gln Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Arg Arg Gly Ala Gly Gly Gln Gly Ser Pro Leu Pro Leu Ala Leu Pro 
                165                 170                 175     


Ala Pro Pro Ser Pro Ala Gly Pro Ala Leu Leu Pro Glu Ala Ser Pro 
            180                 185                 190         


Gly Ala Pro Arg Gly Arg Ala Ala Leu Pro Pro Gly Gly Asn Arg Ala 
        195                 200                 205             


Arg Lys Pro Ser Ala Pro Ser Arg Arg Leu Gln Ala Ala Leu Leu His 
    210                 215                 220                 


Arg Leu Asp Phe Pro Arg Gly Gly Lys Gly Val Arg Phe Gln Val Phe 
225                 230                 235                 240 


Gly Gly Arg Thr Gly Arg Ala His Phe Pro Gln Arg Asn Phe Glu Arg 
                245                 250                 255     


Ser Phe Pro Lys Asp Asp Ser Phe Phe His 
            260                 265     


<210>  4806
<211>  801
<212>  DNA
<213>  Homosapiens

<400>  4806
atggaaaaat tctcctccat gaaactggtt cctggtgcca aaaaggttgg agactgcccc     60

acttcgggag cccccggtgc tccgggccca cctgactggg cgtcctctga gtcagggagg    120

tgccagtgct gtggtccccg cgagcccaac tgtcccctga cccccgggct tttccgcacc    180

gtggagtccc ccgacacgct ggggccagtg aacccgggcc ggggcgcgcg ttctccctcc    240

cggaccagct cccggcgctg ggcccgcggc cgagaaacta ggtctgggcc ggccctgcgg    300

cggccgccgg gcgcggcgag ccccactttc tcccggcagg aaggggggag gccgagagca    360

tttcctgttg tgcagctgag ccctgcggag acgtcattgc attcatgctc cctcgggtgt    420

cagcggacgg ggggccaaag ttcaagccgc gtccagggca ggcagcgcgc ggcggcgcgg    480

cggcgcgggg cgggcggcca gggctcccct ctcccgctgg cgctcccggc gcctccgtcc    540

ccggccggcc cagcgctgct accggaggcc agccctgggg ctccgcgggg aagagctgct    600

cttcctcccg gaggaaaccg agctcgcaag cccagcgctc ccagccgcag actgcaggct    660

gccctcctcc accgcctgga tttcccacgg ggaggaaaag gcgtgcgttt ccaggtgttt    720

ggaggacgca ctggccgggc gcactttcct cagcgtaatt ttgaacgcag tttccctaaa    780

gatgactctt ttttccacta g                                              801


<210>  4807
<211>  266
<212>  PRT
<213>  Homosapiens

<400>  4807

Met Glu Lys Phe Ser Ser Met Lys Leu Val Pro Gly Ala Lys Lys Val 
1               5                   10                  15      


Gly Asp Cys Pro Thr Ser Gly Ala Pro Gly Ala Pro Gly Pro Pro Asp 
            20                  25                  30          


Trp Ala Ser Ser Glu Ser Gly Arg Cys Gln Cys Cys Gly Pro Arg Glu 
        35                  40                  45              


Pro Asn Cys Pro Leu Thr Pro Gly Leu Phe Arg Thr Val Glu Ser Pro 
    50                  55                  60                  


Asp Thr Leu Gly Pro Val Asn Pro Gly Arg Gly Ala Arg Ser Pro Ser 
65                  70                  75                  80  


Arg Thr Ser Ser Arg Arg Trp Ala Arg Gly Arg Glu Thr Arg Ser Gly 
                85                  90                  95      


Pro Ala Leu Arg Arg Pro Pro Gly Ala Ala Ser Pro Thr Phe Ser Arg 
            100                 105                 110         


Gln Glu Gly Gly Arg Pro Arg Ala Phe Pro Val Val Gln Leu Ser Pro 
        115                 120                 125             


Ala Glu Thr Ser Leu His Ser Cys Ser Leu Gly Cys Gln Arg Thr Gly 
    130                 135                 140                 


Gly Gln Ser Ser Ser Arg Val Gln Gly Arg Gln Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Arg Arg Gly Ala Gly Gly Gln Gly Ser Pro Leu Pro Leu Ala Leu Pro 
                165                 170                 175     


Ala Pro Pro Ser Pro Ala Gly Pro Ala Leu Leu Pro Glu Ala Ser Pro 
            180                 185                 190         


Gly Ala Pro Arg Gly Arg Ala Ala Leu Pro Pro Gly Gly Asn Arg Ala 
        195                 200                 205             


Arg Lys Pro Ser Ala Pro Ser Arg Arg Leu Gln Ala Ala Leu Leu His 
    210                 215                 220                 


Arg Leu Asp Phe Pro Arg Gly Gly Lys Gly Val Arg Phe Gln Val Phe 
225                 230                 235                 240 


Gly Gly Arg Thr Gly Arg Ala His Phe Pro Gln Arg Asn Phe Glu Arg 
                245                 250                 255     


Ser Phe Pro Lys Asp Asp Ser Phe Phe His 
            260                 265     


<210>  4808
<211>  831
<212>  DNA
<213>  Homosapiens

<400>  4808
atgggcccgg ggcaggggcc gccgggctca ggcgggagcc gcgaggcccg ggccgcagct     60

gtctgcgtgc gggagccgca gcggccgcct cccctcccgg gctgtggacg caccgggtta    120

ttcctggcag cgcctccccg aacagaagtt actaggagga ggtgcccccg gcacccccag    180

ttcggggacc gcggcccgcc ctcgccaggg gattcaaata ggtgtgggca gcggcgcgaa    240

gagcagctgc cggtttcctg gtgggccgcg ctggaacctc ggggcgagct gccaccttca    300

gcctgtgcgc ttccctctcc acggaaggga ccggagttga aatcacaacc aaccctggga    360

gagcggggcc gggaggcggg ggaatcccag gcgagtggga gccgaagctc tgggcttcct    420

ccccggccgg gcgacacccg ggggacaccg gggctctctc gggccgttac cctgcctatg    480

tggactggtg tgcaccctcg ggggaggttc ctagggtgcc acggtgcccg agcgcgacga    540

gtgactgctg gggagggggg ccgggtcccg gagcgcctcc tccgggtggt ctccccccca    600

gcggggaccg cgcgcagcac ctcgcgggcg ccccagcccc cgcaccctgc ggagcagagc    660

cgagcgccca ggacgccgcg ggccccagcg gtcctcccca ccccctggcc gcgccgccgc    720

cctgcccggg gcggagtaaa caagagacgc gcaagatttg acctggcgcg acccggcttt    780

ctggccgggg ttccccctga gcaggtgact ccgtgggagg ggtggaaatg a             831


<210>  4809
<211>  276
<212>  PRT
<213>  Homosapiens

<400>  4809

Met Gly Pro Gly Gln Gly Pro Pro Gly Ser Gly Gly Ser Arg Glu Ala 
1               5                   10                  15      


Arg Ala Ala Ala Val Cys Val Arg Glu Pro Gln Arg Pro Pro Pro Leu 
            20                  25                  30          


Pro Gly Cys Gly Arg Thr Gly Leu Phe Leu Ala Ala Pro Pro Arg Thr 
        35                  40                  45              


Glu Val Thr Arg Arg Arg Cys Pro Arg His Pro Gln Phe Gly Asp Arg 
    50                  55                  60                  


Gly Pro Pro Ser Pro Gly Asp Ser Asn Arg Cys Gly Gln Arg Arg Glu 
65                  70                  75                  80  


Glu Gln Leu Pro Val Ser Trp Trp Ala Ala Leu Glu Pro Arg Gly Glu 
                85                  90                  95      


Leu Pro Pro Ser Ala Cys Ala Leu Pro Ser Pro Arg Lys Gly Pro Glu 
            100                 105                 110         


Leu Lys Ser Gln Pro Thr Leu Gly Glu Arg Gly Arg Glu Ala Gly Glu 
        115                 120                 125             


Ser Gln Ala Ser Gly Ser Arg Ser Ser Gly Leu Pro Pro Arg Pro Gly 
    130                 135                 140                 


Asp Thr Arg Gly Thr Pro Gly Leu Ser Arg Ala Val Thr Leu Pro Met 
145                 150                 155                 160 


Trp Thr Gly Val His Pro Arg Gly Arg Phe Leu Gly Cys His Gly Ala 
                165                 170                 175     


Arg Ala Arg Arg Val Thr Ala Gly Glu Gly Gly Arg Val Pro Glu Arg 
            180                 185                 190         


Leu Leu Arg Val Val Ser Pro Pro Ala Gly Thr Ala Arg Ser Thr Ser 
        195                 200                 205             


Arg Ala Pro Gln Pro Pro His Pro Ala Glu Gln Ser Arg Ala Pro Arg 
    210                 215                 220                 


Thr Pro Arg Ala Pro Ala Val Leu Pro Thr Pro Trp Pro Arg Arg Arg 
225                 230                 235                 240 


Pro Ala Arg Gly Gly Val Asn Lys Arg Arg Ala Arg Phe Asp Leu Ala 
                245                 250                 255     


Arg Pro Gly Phe Leu Ala Gly Val Pro Pro Glu Gln Val Thr Pro Trp 
            260                 265                 270         


Glu Gly Trp Lys 
        275     


<210>  4810
<211>  831
<212>  DNA
<213>  Homosapiens

<400>  4810
atgggcccgg ggcaggggcc gccgggctca ggcgggagcc gcgaggcccg ggccgcagct     60

gtctgcgtgc gggagccgca gcggccgcct cccctcccgg gctgtggacg caccgggtta    120

ttcctggcag cgcctccccg aacagaagtt actaggagga ggtgcccccg gcacccccag    180

ttcggggacc gcggcccgcc ctcgccaggg gattcaaata ggtgtgggca gcggcgcgaa    240

gagcagctgc cggtttcctg gtgggccgcg ctggaacctc ggggcgagct gccaccttca    300

gcctgtgcgc ttccctctcc acggaaggga ccggagttga aatcacaacc aaccctggga    360

gagcggggcc gggaggcggg ggaatcccag gcgagtggga gccgaagctc tgggcttcct    420

ccccggccgg gcgacacccg ggggacaccg gggctctctc gggccgttac cctgcctatg    480

tggactggtg tgcaccctcg ggggaggttc ctagggtgcc acggtgcccg agcgcgacga    540

gtgactgctg gggagggggg ccgggtcccg gagcgcctcc tccgggtggt ctccccccca    600

gcggggaccg cgcgcagcac ctcgcgggcg ccccagcccc cgcaccctgc ggagcagagc    660

cgagcgccca ggacgccgcg ggccccagcg gtcctcccca ccccctggcc gcgccgccgc    720

cctgcccggg gcggagtaaa caagagacgc gcaagatttg acctggcgcg acccggcttt    780

ctggccgggg ttccccctga gcaggtgact ccgtgggagg ggtggaaatg a             831


<210>  4811
<211>  276
<212>  PRT
<213>  Homosapiens

<400>  4811

Met Gly Pro Gly Gln Gly Pro Pro Gly Ser Gly Gly Ser Arg Glu Ala 
1               5                   10                  15      


Arg Ala Ala Ala Val Cys Val Arg Glu Pro Gln Arg Pro Pro Pro Leu 
            20                  25                  30          


Pro Gly Cys Gly Arg Thr Gly Leu Phe Leu Ala Ala Pro Pro Arg Thr 
        35                  40                  45              


Glu Val Thr Arg Arg Arg Cys Pro Arg His Pro Gln Phe Gly Asp Arg 
    50                  55                  60                  


Gly Pro Pro Ser Pro Gly Asp Ser Asn Arg Cys Gly Gln Arg Arg Glu 
65                  70                  75                  80  


Glu Gln Leu Pro Val Ser Trp Trp Ala Ala Leu Glu Pro Arg Gly Glu 
                85                  90                  95      


Leu Pro Pro Ser Ala Cys Ala Leu Pro Ser Pro Arg Lys Gly Pro Glu 
            100                 105                 110         


Leu Lys Ser Gln Pro Thr Leu Gly Glu Arg Gly Arg Glu Ala Gly Glu 
        115                 120                 125             


Ser Gln Ala Ser Gly Ser Arg Ser Ser Gly Leu Pro Pro Arg Pro Gly 
    130                 135                 140                 


Asp Thr Arg Gly Thr Pro Gly Leu Ser Arg Ala Val Thr Leu Pro Met 
145                 150                 155                 160 


Trp Thr Gly Val His Pro Arg Gly Arg Phe Leu Gly Cys His Gly Ala 
                165                 170                 175     


Arg Ala Arg Arg Val Thr Ala Gly Glu Gly Gly Arg Val Pro Glu Arg 
            180                 185                 190         


Leu Leu Arg Val Val Ser Pro Pro Ala Gly Thr Ala Arg Ser Thr Ser 
        195                 200                 205             


Arg Ala Pro Gln Pro Pro His Pro Ala Glu Gln Ser Arg Ala Pro Arg 
    210                 215                 220                 


Thr Pro Arg Ala Pro Ala Val Leu Pro Thr Pro Trp Pro Arg Arg Arg 
225                 230                 235                 240 


Pro Ala Arg Gly Gly Val Asn Lys Arg Arg Ala Arg Phe Asp Leu Ala 
                245                 250                 255     


Arg Pro Gly Phe Leu Ala Gly Val Pro Pro Glu Gln Val Thr Pro Trp 
            260                 265                 270         


Glu Gly Trp Lys 
        275     


<210>  4812
<211>  1803
<212>  DNA
<213>  Homosapiens

<400>  4812
cgcactccgg acccttcttc agattgcaca ggaggaggcg gtagcggaac ctttctcctc     60

cgcctggttc tcgcttccac ccgggcccag ttggggacgg acgcactaga ggcgacctaa    120

acatggagac agcgggcgct gcaactgggc agccggcctc tgggctggag gctccggggt    180

ccacgaatga ccggcttttc ctggttaaag gtggaatttt ccttggtacc gttgctgcag    240

cgggaatgct agctggattt attacaacat tatcattggc taaaaagaaa agccctgaat    300

ggttcaataa gggaagtatg gccacggctg cattaccgga aagcgggtct tcccttgcct    360

tgcgagctct gggctggggc tccctgtatg catggtgtgg ggttggtgtg attagcttcg    420

cagtctggaa agctttagga gttcacagta tgaacgactt tcgaagtaaa atgcaatcaa    480

tatttccaac aattcccaag aactccgaat cggctgttga gtgggaggaa acattgaaat    540

ccaaatgaga tgagcatgga tgaatttcaa aatgcttgtt acagaaaggg gtggctctgg    600

agacaccatg acagcaaaag gactgggact gatttctccc aggaacatgg gcagattgct    660

gactgaacca gtgcactgga tagcattcag cctcatcaca ggagagtatg tgtgtgcgtg    720

ctgggggagg gtaaagtttt cccacagtta agaagactat ttaaaaatag taattacagg    780

aataacttcc ttatgtggag gggaccccat aggaaatgat tctgtttgta acagttgaag    840

caaatttcat actaaaaaag tttataataa aagtatgata agaaaatatt tataaaacag    900

accccctaat agcaatagta ctgcaatgtg tctaattaaa ggagtttcaa gagcctttct    960

tgtcaatata tgacagaact tggaagtctt attctgatta gccagactac aaagtgacag   1020

tcacctggta agtcctgtat ggtaggaagt gggtgtggct ctcgggtcct aaatgtggtc   1080

tgtgctttac agccatcaca cacatgctag ttatttacct gatgcccttg cttgaaggcc   1140

ctataaattc ttatacttaa aacaaaaagc cagtaatgag ttgtgatcac cccaaaaggc   1200

acagttgggc taaaataatg atgatatcag gggtaaacat atttttttga gaagttggtc   1260

tggatctctg aacactgaca atttgtcatt ttgtctcagt tgtcaaagta aaaaaagccc   1320

agttgtcatc cgtcttcaat atttttaacc agaaagtcac ctgagtacgg agtcccaata   1380

taaagtattt gggaccacct ccctaacaaa gctgttaggg taaattctgt gtgcacgccc   1440

aactccctcc tgtcttccac agtctcctac aaaaaaaaca gatggagaat aatgtctaca   1500

tgcaattgtt tttactgcaa ttgtatttta aaatattttc aagaagagaa atactttaat   1560

atgtcaatat gtccagagaa aaaacctgta gttaaatatc agttgtgcaa tttcttccta   1620

cttgcctagg ctctaattag tcagcaatca ggtttaataa aggacatttg aaatttctgt   1680

tatcatgaaa ccttttattc taagggagat ttttaaatga aatgacaaga acttaatgta   1740

atacttttct ctagaccatg ttaccctgtt aaaattgctg tattgttaat gaaacaggtg   1800

taa                                                                 1803


<210>  4813
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  4813

Met Glu Thr Ala Gly Ala Ala Thr Gly Gln Pro Ala Ser Gly Leu Glu 
1               5                   10                  15      


Ala Pro Gly Ser Thr Asn Asp Arg Leu Phe Leu Val Lys Gly Gly Ile 
            20                  25                  30          


Phe Leu Gly Thr Val Ala Ala Ala Gly Met Leu Ala Gly Phe Ile Thr 
        35                  40                  45              


Thr Leu Ser Leu Ala Lys Lys Lys Ser Pro Glu Trp Phe Asn Lys Gly 
    50                  55                  60                  


Ser Met Ala Thr Ala Ala Leu Pro Glu Ser Gly Ser Ser Leu Ala Leu 
65                  70                  75                  80  


Arg Ala Leu Gly Trp Gly Ser Leu Tyr Ala Trp Cys Gly Val Gly Val 
                85                  90                  95      


Ile Ser Phe Ala Val Trp Lys Ala Leu Gly Val His Ser Met Asn Asp 
            100                 105                 110         


Phe Arg Ser Lys Met Gln Ser Ile Phe Pro Thr Ile Pro Lys Asn Ser 
        115                 120                 125             


Glu Ser Ala Val Glu Trp Glu Glu Thr Leu Lys Ser Lys 
    130                 135                 140     


<210>  4814
<211>  1608
<212>  DNA
<213>  Homosapiens

<400>  4814
tgcgcactcg ccacagaggg ctgaaggtgc tgctaatggc tctcttggcg ttgcgacgtc     60

ctggtcagca gttttcttcc attctctccc tccatttctt gagtgagcag ccatgagttg    120

gactgtgtct gttgtgcagg ccagccggag agtgagctcg gcaggagcga atttcctgtc    180

cctgtgtccc agtcaggcag cgcgcatgcc gctcaagggc gcctggctct tcacccccgt    240

gaagagtgag cttgttgagc gcttcacttc cgaggagccc gctcatcaca gtaaggtctc    300

catcatagga actggatcgg tgggcatggc ctgcgctacc agcatcttat taaaaggctt    360

gagtgatgaa cttgcccttg tggatcttga tgaaggcaaa ctgaagggtg agacaatgga    420

tcttcaacat ggcagccctt tcatgaaaac gccaaatatt gtttgtagca aagattacct    480

tgtcacagca aactccagcc tagtgattat cacagaaggt gcacgtcaag aaaagggaga    540

aacgcgcctt aatttagtcc agcgaaatgt ggccatcttc aagttaatga tttccggtat    600

tgtccagtac agccccctct gcaagctgat tattgtttcc aatccagtgg ataacttaac    660

ttatgtagcc tggaagttga gtgcattttc caaaaaccgt gttattggaa gcggctgtaa    720

tctggatact gctcgttttt gtttcttgtt tggacaaaag cttggtatcc actctgaaaa    780

ctgccacgga tggatcctag gagagcatgg agactcaagt gttcctgtat ggagtggagt    840

gaacatagct ggtgtcgctt tgaagaatct gaactctgat acaggaactg ataaagatcc    900

tgaacaatgg aaaaatgtcc acaagtgatt gctagtgcct atgagattat taaaatgaaa    960

ggttatactt catgggccat tggcctatct gtagctgatt taacagaaag tattttgaag   1020

aatcttagga gaacacatcc agtttccacc atcattaggg gtctctgtgg aatagatgaa   1080

gaagtattcc tcaatattcc ttgtgtcctg ggaaagctga cccctgaaga ggaggccccc   1140

ctgaaagaga gtgcaaaaac actttgagaa attcagaagg aactgaagct ttaaagttgt   1200

ctaaaactac cattctgaaa ttattgaaga gatcatagat atagggttat atatcaaaat   1260

tttgaataaa cttaaattcc taaaatatgg aaacaggaaa gtggataaaa tgacttacct   1320

atttatttag tcctccagct cttttattta gcatccaggt gctgggtgat acttatttac   1380

aattcctaaa gaaagtgttt ttggtacccc tgatgtagca gcacttgcct tgttatatat   1440

gtagttggca tttggttccc aaaaagtagg atgtaagtat ttattgtgtt ctagatattc   1500

tgattatttt cattagatac atgctttctt cttgctggct tatacctatg ttcatttata   1560

tgctgtaaaa aagtggtaac ttcctctaca atgtaaaaat aaaagtat                1608


<210>  4815
<211>  271
<212>  PRT
<213>  Homosapiens

<400>  4815

Met Ser Trp Thr Val Ser Val Val Gln Ala Ser Arg Arg Val Ser Ser 
1               5                   10                  15      


Ala Gly Ala Asn Phe Leu Ser Leu Cys Pro Ser Gln Ala Ala Arg Met 
            20                  25                  30          


Pro Leu Lys Gly Ala Trp Leu Phe Thr Pro Val Lys Ser Glu Leu Val 
        35                  40                  45              


Glu Arg Phe Thr Ser Glu Glu Pro Ala His His Ser Lys Val Ser Ile 
    50                  55                  60                  


Ile Gly Thr Gly Ser Val Gly Met Ala Cys Ala Thr Ser Ile Leu Leu 
65                  70                  75                  80  


Lys Gly Leu Ser Asp Glu Leu Ala Leu Val Asp Leu Asp Glu Gly Lys 
                85                  90                  95      


Leu Lys Gly Glu Thr Met Asp Leu Gln His Gly Ser Pro Phe Met Lys 
            100                 105                 110         


Thr Pro Asn Ile Val Cys Ser Lys Asp Tyr Leu Val Thr Ala Asn Ser 
        115                 120                 125             


Ser Leu Val Ile Ile Thr Glu Gly Ala Arg Gln Glu Lys Gly Glu Thr 
    130                 135                 140                 


Arg Leu Asn Leu Val Gln Arg Asn Val Ala Ile Phe Lys Leu Met Ile 
145                 150                 155                 160 


Ser Gly Ile Val Gln Tyr Ser Pro Leu Cys Lys Leu Ile Ile Val Ser 
                165                 170                 175     


Asn Pro Val Asp Asn Leu Thr Tyr Val Ala Trp Lys Leu Ser Ala Phe 
            180                 185                 190         


Ser Lys Asn Arg Val Ile Gly Ser Gly Cys Asn Leu Asp Thr Ala Arg 
        195                 200                 205             


Phe Cys Phe Leu Phe Gly Gln Lys Leu Gly Ile His Ser Glu Asn Cys 
    210                 215                 220                 


His Gly Trp Ile Leu Gly Glu His Gly Asp Ser Ser Val Pro Val Trp 
225                 230                 235                 240 


Ser Gly Val Asn Ile Ala Gly Val Ala Leu Lys Asn Leu Asn Ser Asp 
                245                 250                 255     


Thr Gly Thr Asp Lys Asp Pro Glu Gln Trp Lys Asn Val His Lys 
            260                 265                 270     


<210>  4816
<211>  675
<212>  DNA
<213>  Homosapiens

<400>  4816
atggattcca ctggccagcc ggactggaac aacttctccc cttataagta tctagaaggc     60

gcccccggca caccagcccc tctcagcgcc cccagcgggc ccggcgcctg gagggttaag    120

gcgggcgcgt cccgcgggtg ggcggggggg gggggacggg accggtgccg ggagctccgc    180

tgccctggcg tcccctgggt ccaggcccag tcgctccttg ggcctctctc gcggggccgc    240

ctccgcctcc tccttgccga gacgggcgtg gggcacgggg tcgccgcccg gcggggagct    300

catccggcgg cgcagacgcc ccgcggctcc ggggagggac ttggcctggg ccccggcccc    360

gcgctcctct ggggaggagc cgagaggctg cagctggcgg cggcggcccc gggcgggagg    420

gggtcccagg aagcggccag gccggagccc cccactcggc cgcagctgct ggcctggcca    480

gaaccgagcg cgccctcccg ccgccccccg cgcgcccggc tccgcggacc aggacccctg    540

ggctccccgg ctgagggcgc ggccgctccg gagaggccga gcggggacgg gcccgagatg    600

gcgcggggac ccagcgctcc ggcggcgggc gccctgcacg cggcccgggc ccggggacag    660

ccccggagct ggtag                                                     675


<210>  4817
<211>  224
<212>  PRT
<213>  Homosapiens

<400>  4817

Met Asp Ser Thr Gly Gln Pro Asp Trp Asn Asn Phe Ser Pro Tyr Lys 
1               5                   10                  15      


Tyr Leu Glu Gly Ala Pro Gly Thr Pro Ala Pro Leu Ser Ala Pro Ser 
            20                  25                  30          


Gly Pro Gly Ala Trp Arg Val Lys Ala Gly Ala Ser Arg Gly Trp Ala 
        35                  40                  45              


Gly Gly Gly Gly Arg Asp Arg Cys Arg Glu Leu Arg Cys Pro Gly Val 
    50                  55                  60                  


Pro Trp Val Gln Ala Gln Ser Leu Leu Gly Pro Leu Ser Arg Gly Arg 
65                  70                  75                  80  


Leu Arg Leu Leu Leu Ala Glu Thr Gly Val Gly His Gly Val Ala Ala 
                85                  90                  95      


Arg Arg Gly Ala His Pro Ala Ala Gln Thr Pro Arg Gly Ser Gly Glu 
            100                 105                 110         


Gly Leu Gly Leu Gly Pro Gly Pro Ala Leu Leu Trp Gly Gly Ala Glu 
        115                 120                 125             


Arg Leu Gln Leu Ala Ala Ala Ala Pro Gly Gly Arg Gly Ser Gln Glu 
    130                 135                 140                 


Ala Ala Arg Pro Glu Pro Pro Thr Arg Pro Gln Leu Leu Ala Trp Pro 
145                 150                 155                 160 


Glu Pro Ser Ala Pro Ser Arg Arg Pro Pro Arg Ala Arg Leu Arg Gly 
                165                 170                 175     


Pro Gly Pro Leu Gly Ser Pro Ala Glu Gly Ala Ala Ala Pro Glu Arg 
            180                 185                 190         


Pro Ser Gly Asp Gly Pro Glu Met Ala Arg Gly Pro Ser Ala Pro Ala 
        195                 200                 205             


Ala Gly Ala Leu His Ala Ala Arg Ala Arg Gly Gln Pro Arg Ser Trp 
    210                 215                 220                 


<210>  4818
<211>  1437
<212>  DNA
<213>  Homosapiens

<400>  4818
atgcgacccc gtgacagtgc cgttctgctc cgtgagagaa ggctcagggg acagccgccg     60

tgcgaccccg tgacggtgcc gttctgctcc gtgagagaat gctcagggga cagccgctgt    120

gagacccccc tgcaggctga cccctctgca ggcaccaggt gccgtcccca cggggctcgg    180

tgcagcagcc gggacgcccc acacacagac gagccggctg cagacgtcac ttgcagggac    240

atgcccctcc ctcccgggtg cccagatgct aagaacggct cctgcagccc cctgccctgc    300

tggagacgag gctccgccct gtgcccagat gctaagaacg gctcctgcag ccccctgccc    360

tgctggagac gaggctccac cctgtgccca gatgctaaga acggctcctg cagccccctg    420

ccctgctgga gacgaggctc cgccctgtgc ccagatgcta aggacggctc ctgcagcccc    480

ctgccctgct ggagacgagg ctccgccctg tgcccagatg ctaaggacgg ctcctgcagc    540

cccctgccct gctggagacg aggctccgcc ctgtgcccag atgctaagaa cggctcctgc    600

agccccctgc cctgctggag acgaggctcc gccctgtgcc cagatgctaa gaacggctcc    660

tgcagccccc tgccctgctg gagacgaggc tccgccctgt gcccagatgc taagaacggc    720

tcctgcagcc ccctgccctg ctggagacga ggctccgccc tgtgcccaga tgctaagaac    780

ggctcctgca gccccctgcc ctgctggaga cgaggctccg ccctgtgccc agatgctaag    840

aacggctcct gcagccccct gccctgctgg agacgaggct ccgccctgtg cccagatgct    900

aagaacggct cctgcagccc cctgccctgc tggagacgag cctccgccct gtgcccagat    960

gctaagaacg gctcctgcag ccccctgccc tgctggagac gaggctccgc cctgtgccca   1020

gatgctaagg acggctcctg cagccccctg ccctgctgga gacgaggctc cgccctgtgc   1080

ccagatgcta aggacggctc ctgcagcccc ctgccctgct ggagacgagg ctccgccctg   1140

tgcccagatg ctaagaacgg ctcctgcagc cccctgccct gctggagacg aggctccgcc   1200

ctgtgcccag atgctaagaa cggctcctgc agccccctgc cctgctggag acgaggctcc   1260

gccctgtgcc cagatgctaa gaacggctcc tgcagccccc tgccctgctg gagacgaggc   1320

tccgccctgt gcccagatgc taagaacggc tcctgcagcc ccctgccctg ctggagacga   1380

gcctccgccc tgtgcccaga tgctaagaac ggctcctgca gccccctgcc ctgctag      1437


<210>  4819
<211>  478
<212>  PRT
<213>  Homosapiens

<400>  4819

Met Arg Pro Arg Asp Ser Ala Val Leu Leu Arg Glu Arg Arg Leu Arg 
1               5                   10                  15      


Gly Gln Pro Pro Cys Asp Pro Val Thr Val Pro Phe Cys Ser Val Arg 
            20                  25                  30          


Glu Cys Ser Gly Asp Ser Arg Cys Glu Thr Pro Leu Gln Ala Asp Pro 
        35                  40                  45              


Ser Ala Gly Thr Arg Cys Arg Pro His Gly Ala Arg Cys Ser Ser Arg 
    50                  55                  60                  


Asp Ala Pro His Thr Asp Glu Pro Ala Ala Asp Val Thr Cys Arg Asp 
65                  70                  75                  80  


Met Pro Leu Pro Pro Gly Cys Pro Asp Ala Lys Asn Gly Ser Cys Ser 
                85                  90                  95      


Pro Leu Pro Cys Trp Arg Arg Gly Ser Ala Leu Cys Pro Asp Ala Lys 
            100                 105                 110         


Asn Gly Ser Cys Ser Pro Leu Pro Cys Trp Arg Arg Gly Ser Thr Leu 
        115                 120                 125             


Cys Pro Asp Ala Lys Asn Gly Ser Cys Ser Pro Leu Pro Cys Trp Arg 
    130                 135                 140                 


Arg Gly Ser Ala Leu Cys Pro Asp Ala Lys Asp Gly Ser Cys Ser Pro 
145                 150                 155                 160 


Leu Pro Cys Trp Arg Arg Gly Ser Ala Leu Cys Pro Asp Ala Lys Asp 
                165                 170                 175     


Gly Ser Cys Ser Pro Leu Pro Cys Trp Arg Arg Gly Ser Ala Leu Cys 
            180                 185                 190         


Pro Asp Ala Lys Asn Gly Ser Cys Ser Pro Leu Pro Cys Trp Arg Arg 
        195                 200                 205             


Gly Ser Ala Leu Cys Pro Asp Ala Lys Asn Gly Ser Cys Ser Pro Leu 
    210                 215                 220                 


Pro Cys Trp Arg Arg Gly Ser Ala Leu Cys Pro Asp Ala Lys Asn Gly 
225                 230                 235                 240 


Ser Cys Ser Pro Leu Pro Cys Trp Arg Arg Gly Ser Ala Leu Cys Pro 
                245                 250                 255     


Asp Ala Lys Asn Gly Ser Cys Ser Pro Leu Pro Cys Trp Arg Arg Gly 
            260                 265                 270         


Ser Ala Leu Cys Pro Asp Ala Lys Asn Gly Ser Cys Ser Pro Leu Pro 
        275                 280                 285             


Cys Trp Arg Arg Gly Ser Ala Leu Cys Pro Asp Ala Lys Asn Gly Ser 
    290                 295                 300                 


Cys Ser Pro Leu Pro Cys Trp Arg Arg Ala Ser Ala Leu Cys Pro Asp 
305                 310                 315                 320 


Ala Lys Asn Gly Ser Cys Ser Pro Leu Pro Cys Trp Arg Arg Gly Ser 
                325                 330                 335     


Ala Leu Cys Pro Asp Ala Lys Asp Gly Ser Cys Ser Pro Leu Pro Cys 
            340                 345                 350         


Trp Arg Arg Gly Ser Ala Leu Cys Pro Asp Ala Lys Asp Gly Ser Cys 
        355                 360                 365             


Ser Pro Leu Pro Cys Trp Arg Arg Gly Ser Ala Leu Cys Pro Asp Ala 
    370                 375                 380                 


Lys Asn Gly Ser Cys Ser Pro Leu Pro Cys Trp Arg Arg Gly Ser Ala 
385                 390                 395                 400 


Leu Cys Pro Asp Ala Lys Asn Gly Ser Cys Ser Pro Leu Pro Cys Trp 
                405                 410                 415     


Arg Arg Gly Ser Ala Leu Cys Pro Asp Ala Lys Asn Gly Ser Cys Ser 
            420                 425                 430         


Pro Leu Pro Cys Trp Arg Arg Gly Ser Ala Leu Cys Pro Asp Ala Lys 
        435                 440                 445             


Asn Gly Ser Cys Ser Pro Leu Pro Cys Trp Arg Arg Ala Ser Ala Leu 
    450                 455                 460                 


Cys Pro Asp Ala Lys Asn Gly Ser Cys Ser Pro Leu Pro Cys 
465                 470                 475             


<210>  4820
<211>  2818
<212>  DNA
<213>  Homosapiens

<400>  4820
acgcgcgccc tgcggagccc gcccaactcc ggcgagccgg gcctgcgcct actcctcctc     60

ctcctctccc ggcggcggct gcggcggagg cgccgactcg gccttgcgcc cgccctcagg    120

cccgcgcggg cggcgcagcg aggccccggg cggcgggtgg tggctgccag gcggctcggc    180

cgcgggcgct gcccggcccc ggcgagcgga gggcggagcg cggcgccgga gccgagggcg    240

cgccgcggag ggggtgctgg gccgcgctgt gcccggccgg gcggcggctg caagaggagg    300

ccggaggcga gcgcggggcc ggcggtgggc gcgcagggcg gctcgcagct cgcagccggg    360

gccgggccag gcgttcaggc aggtgatcgg tgtggcggcg gcggcggcgg cggccccaga    420

ctccctccgg agttcttctt ggggctgatg tccgcaaata tgcagaatta ccggccgggt    480

cgctcctgaa gccagcgcgg ggagcgagcg cggcggcggc cagcaccggg aacgcaccga    540

ggaagaagcc cagcccccgc cctccgcccc ttccgtcccc accccctacc cggcggccca    600

ggaggctccc cgcgctgcgg gcgcgcactc cctgtttctc ctcctcctgg ctggcgctgc    660

ctgcctctcc gcactcactg ctcgcgccgg gcgcgctccg ccagctccgt gctccccgcg    720

ccaccctcct ccgggccgcg ctccctaagg gatggtactg aatttcgccg ccacaggaga    780

ccggctggag cgcccgcccc gcggcctcgc ctctcctccg agcagccagc gcctcgggac    840

gcgatgagga ccttggcttg cctgctgctc ctcggctgcg gatacctcgc ccatgttctg    900

gccgaggaag ccgagatccc ccgcgaggtg atcgagaggc tggcccgcag tcagatccac    960

agcatccggg acctccagcg actcctggag atagactccg tagggagtga ggattctttg   1020

gacaccagcc tgagagctca cggggtccat gccactaagc atgtgcccga gaagcggccc   1080

ctgcccattc ggaggaagag aagcatcgag gaagctgtcc ccgctgtctg caagaccagg   1140

acggtcattt acgagattcc tcggagtcag gtcgacccca cgtccgccaa cttcctgatc   1200

tggcccccgt gcgtggaggt gaaacgctgc accggctgct gcaacacgag cagtgtcaag   1260

tgccagccct cccgcgtcca ccaccgcagc gtcaaggtgg ccaaggtgga atacgtcagg   1320

aagaagccaa aattaaaaga agtccaggtg aggttagagg agcatttgga gtgcgcctgc   1380

gcgaccacaa gcctgaatcc ggattatcgg gaagaggaca cgggaaggcc tagggagtca   1440

ggtaaaaaac ggaaaagaaa aaggttaaaa cccacctaaa gcagccaacc agatgtgagg   1500

tgaggatgag ccgcagccct ttcctgggac atggatgtac atggcgtgtt acattcctga   1560

acctactatg tacggtgctt tattgccagt gtgcggtctt tgttctcctc cgtgaaaaac   1620

tgtgtccgag aacactcggg agaacaaaga gacagtgcac atttgtttaa tgtgacatca   1680

aagcaagtat tgtagcactc ggtgaagcag taagaagctt ccttgtcaaa aagagagaga   1740

gagagagaga gagagaaaac aaaaccacaa atgacaaaaa caaaacggac tcacaaaaat   1800

atctaaactc gatgagatgg agggtcgccc cgtgggatgg aagtgcagag gtctcagcag   1860

actggatttc tgtccgggtg gtcacaggtg cttttttgcc gaggatgcag agcctgcttt   1920

gggaacgact ccagaggggt gctggtgggc tctgcagggg cccgcaggaa gcaggaatgt   1980

cttggaaacc gccacgcgaa ctttagaaac cacacctcct cgctgtagta tttaagccca   2040

tacagaaacc ttcctgagag ccttaagtgg tttttttttt ttgtttttgt tttgtttttt   2100

ttttttttgt tttttttttt ttttttttta caccataaag tgattattaa gctttccttt   2160

ttactctttg gctagctttt tttttttttt tttttaatta tctcttggat gacatttaca   2220

ccgataacac acaggctgct gtaactgtca ggacagtgcg acggtatttt tcctagcaag   2280

atgcaaacta atgagatgta ttaaaataaa catggtatac ctacctatgc atcatttcct   2340

aaatgtttct ggctttgtgt ttctccctta ccctgcttta tttgttaatt taagccattt   2400

tgaaagaact atgcgtcaac caatcgtacg ccgtccctgc ggcacctgcc ccagagcccg   2460

tttgtggctg agtgacaact tgttccccgc agtgcacacc tagaatgctg tgttcccacg   2520

cggcacgtga gatgcattgc cgcttctgtc tgtgttgttg gtgtgccctg gtgccgtggt   2580

ggcggtcact ccctctgctg ccagtgtttg gacagaaccc aaattcttta tttttggtaa   2640

gatattgtgc tttacctgta ttaacagaaa tgtgtgtgtg tggtttgttt ttttgtaaag   2700

gtgaagtttg tatgtttact taatattacc tgttttgtat acctgagagc ctgctatgtt   2760

ctttttttgt tgatccaaaa ttaaaaaaaa aaataccacc aacaaaaaaa aaaaaaaa     2818


<210>  4821
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  4821

Met Arg Thr Leu Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


His Val Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala Arg Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Val His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg Ser Ile Glu Glu Ala Val Pro Ala Val Cys 
                85                  90                  95      


Lys Thr Arg Thr Val Ile Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro 
            100                 105                 110         


Thr Ser Ala Asn Phe Leu Ile Trp Pro Pro Cys Val Glu Val Lys Arg 
        115                 120                 125             


Cys Thr Gly Cys Cys Asn Thr Ser Ser Val Lys Cys Gln Pro Ser Arg 
    130                 135                 140                 


Val His His Arg Ser Val Lys Val Ala Lys Val Glu Tyr Val Arg Lys 
145                 150                 155                 160 


Lys Pro Lys Leu Lys Glu Val Gln Val Arg Leu Glu Glu His Leu Glu 
                165                 170                 175     


Cys Ala Cys Ala Thr Thr Ser Leu Asn Pro Asp Tyr Arg Glu Glu Asp 
            180                 185                 190         


Thr Gly Arg Pro Arg Glu Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
        195                 200                 205             


Lys Pro Thr 
    210     


<210>  4822
<211>  2749
<212>  DNA
<213>  Homosapiens

<400>  4822
acgcgcgccc tgcggagccc gcccaactcc ggcgagccgg gcctgcgcct actcctcctc     60

ctcctctccc ggcggcggct gcggcggagg cgccgactcg gccttgcgcc cgccctcagg    120

cccgcgcggg cggcgcagcg aggccccggg cggcgggtgg tggctgccag gcggctcggc    180

cgcgggcgct gcccggcccc ggcgagcgga gggcggagcg cggcgccgga gccgagggcg    240

cgccgcggag ggggtgctgg gccgcgctgt gcccggccgg gcggcggctg caagaggagg    300

ccggaggcga gcgcggggcc ggcggtgggc gcgcagggcg gctcgcagct cgcagccggg    360

gccgggccag gcgttcaggc aggtgatcgg tgtggcggcg gcggcggcgg cggccccaga    420

ctccctccgg agttcttctt ggggctgatg tccgcaaata tgcagaatta ccggccgggt    480

cgctcctgaa gccagcgcgg ggagcgagcg cggcggcggc cagcaccggg aacgcaccga    540

ggaagaagcc cagcccccgc cctccgcccc ttccgtcccc accccctacc cggcggccca    600

ggaggctccc cgcgctgcgg gcgcgcactc cctgtttctc ctcctcctgg ctggcgctgc    660

ctgcctctcc gcactcactg ctcgcgccgg gcgcgctccg ccagctccgt gctccccgcg    720

ccaccctcct ccgggccgcg ctccctaagg gatggtactg aatttcgccg ccacaggaga    780

ccggctggag cgcccgcccc gcggcctcgc ctctcctccg agcagccagc gcctcgggac    840

gcgatgagga ccttggcttg cctgctgctc ctcggctgcg gatacctcgc ccatgttctg    900

gccgaggaag ccgagatccc ccgcgaggtg atcgagaggc tggcccgcag tcagatccac    960

agcatccggg acctccagcg actcctggag atagactccg tagggagtga ggattctttg   1020

gacaccagcc tgagagctca cggggtccat gccactaagc atgtgcccga gaagcggccc   1080

ctgcccattc ggaggaagag aagcatcgag gaagctgtcc ccgctgtctg caagaccagg   1140

acggtcattt acgagattcc tcggagtcag gtcgacccca cgtccgccaa cttcctgatc   1200

tggcccccgt gcgtggaggt gaaacgctgc accggctgct gcaacacgag cagtgtcaag   1260

tgccagccct cccgcgtcca ccaccgcagc gtcaaggtgg ccaaggtgga atacgtcagg   1320

aagaagccaa aattaaaaga agtccaggtg aggttagagg agcatttgga gtgcgcctgc   1380

gcgaccacaa gcctgaatcc ggattatcgg gaagaggaca cggatgtgag gtgaggatga   1440

gccgcagccc tttcctggga catggatgta catggcgtgt tacattcctg aacctactat   1500

gtacggtgct ttattgccag tgtgcggtct ttgttctcct ccgtgaaaaa ctgtgtccga   1560

gaacactcgg gagaacaaag agacagtgca catttgttta atgtgacatc aaagcaagta   1620

ttgtagcact cggtgaagca gtaagaagct tccttgtcaa aaagagagag agagagagag   1680

agagagaaaa caaaaccaca aatgacaaaa acaaaacgga ctcacaaaaa tatctaaact   1740

cgatgagatg gagggtcgcc ccgtgggatg gaagtgcaga ggtctcagca gactggattt   1800

ctgtccgggt ggtcacaggt gcttttttgc cgaggatgca gagcctgctt tgggaacgac   1860

tccagagggg tgctggtggg ctctgcaggg gcccgcagga agcaggaatg tcttggaaac   1920

cgccacgcga actttagaaa ccacacctcc tcgctgtagt atttaagccc atacagaaac   1980

cttcctgaga gccttaagtg gttttttttt tttgtttttg ttttgttttt tttttttttg   2040

tttttttttt tttttttttt acaccataaa gtgattatta agctttcctt tttactcttt   2100

ggctagcttt tttttttttt ttttttaatt atctcttgga tgacatttac accgataaca   2160

cacaggctgc tgtaactgtc aggacagtgc gacggtattt ttcctagcaa gatgcaaact   2220

aatgagatgt attaaaataa acatggtata cctacctatg catcatttcc taaatgtttc   2280

tggctttgtg tttctccctt accctgcttt atttgttaat ttaagccatt ttgaaagaac   2340

tatgcgtcaa ccaatcgtac gccgtccctg cggcacctgc cccagagccc gtttgtggct   2400

gagtgacaac ttgttccccg cagtgcacac ctagaatgct gtgttcccac gcggcacgtg   2460

agatgcattg ccgcttctgt ctgtgttgtt ggtgtgccct ggtgccgtgg tggcggtcac   2520

tccctctgct gccagtgttt ggacagaacc caaattcttt atttttggta agatattgtg   2580

ctttacctgt attaacagaa atgtgtgtgt gtggtttgtt tttttgtaaa ggtgaagttt   2640

gtatgtttac ttaatattac ctgttttgta tacctgagag cctgctatgt tctttttttg   2700

ttgatccaaa attaaaaaaa aaaataccac caacaaaaaa aaaaaaaaa               2749


<210>  4823
<211>  196
<212>  PRT
<213>  Homosapiens

<400>  4823

Met Arg Thr Leu Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


His Val Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala Arg Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Val His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg Ser Ile Glu Glu Ala Val Pro Ala Val Cys 
                85                  90                  95      


Lys Thr Arg Thr Val Ile Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro 
            100                 105                 110         


Thr Ser Ala Asn Phe Leu Ile Trp Pro Pro Cys Val Glu Val Lys Arg 
        115                 120                 125             


Cys Thr Gly Cys Cys Asn Thr Ser Ser Val Lys Cys Gln Pro Ser Arg 
    130                 135                 140                 


Val His His Arg Ser Val Lys Val Ala Lys Val Glu Tyr Val Arg Lys 
145                 150                 155                 160 


Lys Pro Lys Leu Lys Glu Val Gln Val Arg Leu Glu Glu His Leu Glu 
                165                 170                 175     


Cys Ala Cys Ala Thr Thr Ser Leu Asn Pro Asp Tyr Arg Glu Glu Asp 
            180                 185                 190         


Thr Asp Val Arg 
        195     


<210>  4824
<211>  588
<212>  DNA
<213>  Homosapiens

<400>  4824
atgcgaactg ttgtttccca taacccatgg ttctcagaag aaggcacgct agacttagag     60

ctctgggaac aagtgggaag aaatcttaaa agacatcatg cacaagggca acgggtccta    120

gtaacatctt taatgttatg ggcgttaggt agggctgctt tgtccctgct ctatacagaa    180

gagcctaaaa agggaaggga agaggaacca tcacctacct tactgccccc tcctcctccc    240

tcagccctgc cgttatgggt cctctttgga ttccagcatg acacatcaaa ccataccacg    300

gcatggctgg gacccaacct ggtaccagaa atgaaggaaa tgatcctgca ggacccacat    360

ccccagatga tgcagcttcc ttggacaaca caggccctgg acattatgct gatggagaca    420

actcagaagg ctgagcaaat cctgctccag acacaaacac tgttcactcc agataatctg    480

ttccttgcta ttctctctga tgcaaagcca gaacacaact gtaaccactg tgcctgtcaa    540

gcctgtcact gtgcacatct gtgtgctact tcaatcaaca aaacctga                 588


<210>  4825
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  4825

Met Arg Thr Val Val Ser His Asn Pro Trp Phe Ser Glu Glu Gly Thr 
1               5                   10                  15      


Leu Asp Leu Glu Leu Trp Glu Gln Val Gly Arg Asn Leu Lys Arg His 
            20                  25                  30          


His Ala Gln Gly Gln Arg Val Leu Val Thr Ser Leu Met Leu Trp Ala 
        35                  40                  45              


Leu Gly Arg Ala Ala Leu Ser Leu Leu Tyr Thr Glu Glu Pro Lys Lys 
    50                  55                  60                  


Gly Arg Glu Glu Glu Pro Ser Pro Thr Leu Leu Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Ser Ala Leu Pro Leu Trp Val Leu Phe Gly Phe Gln His Asp Thr Ser 
                85                  90                  95      


Asn His Thr Thr Ala Trp Leu Gly Pro Asn Leu Val Pro Glu Met Lys 
            100                 105                 110         


Glu Met Ile Leu Gln Asp Pro His Pro Gln Met Met Gln Leu Pro Trp 
        115                 120                 125             


Thr Thr Gln Ala Leu Asp Ile Met Leu Met Glu Thr Thr Gln Lys Ala 
    130                 135                 140                 


Glu Gln Ile Leu Leu Gln Thr Gln Thr Leu Phe Thr Pro Asp Asn Leu 
145                 150                 155                 160 


Phe Leu Ala Ile Leu Ser Asp Ala Lys Pro Glu His Asn Cys Asn His 
                165                 170                 175     


Cys Ala Cys Gln Ala Cys His Cys Ala His Leu Cys Ala Thr Ser Ile 
            180                 185                 190         


Asn Lys Thr 
        195 


<210>  4826
<211>  588
<212>  DNA
<213>  Homosapiens

<400>  4826
atgcgaactg ttgtttccca taacccatgg ttctcagaag aaggcacgct agacttagag     60

ctctgggaac aagtgggaag aaatcttaaa agacatcatg cacaagggca acgggtccta    120

gtaacatctt taatgttatg ggcgttaggt agggctgctt tgtccctgct ctatacagaa    180

gagcctaaaa agggaaggga agaggaacca tcacctacct tactgccccc tcctcctccc    240

tcagccctgc cgttatgggt cctctttgga ttccagcatg acacatcaaa ccataccacg    300

gcatggctgg gacccaacct ggtaccagaa atgaaggaaa tgatcctgca ggacccacat    360

ccccagatga tgcagcttcc ttggacaaca caggccctgg acattatgct gatggagaca    420

actcagaagg ctgagcaaat cctgctccag acacaaacac tgttcactcc agataatctg    480

ttccttgcta ttctctctga tgcaaagcca gaacacaact gtaaccactg tgcctgtcaa    540

gcctgtcact gtgcacatct gtgtgctact tcaatcaaca aaacctga                 588


<210>  4827
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  4827

Met Arg Thr Val Val Ser His Asn Pro Trp Phe Ser Glu Glu Gly Thr 
1               5                   10                  15      


Leu Asp Leu Glu Leu Trp Glu Gln Val Gly Arg Asn Leu Lys Arg His 
            20                  25                  30          


His Ala Gln Gly Gln Arg Val Leu Val Thr Ser Leu Met Leu Trp Ala 
        35                  40                  45              


Leu Gly Arg Ala Ala Leu Ser Leu Leu Tyr Thr Glu Glu Pro Lys Lys 
    50                  55                  60                  


Gly Arg Glu Glu Glu Pro Ser Pro Thr Leu Leu Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Ser Ala Leu Pro Leu Trp Val Leu Phe Gly Phe Gln His Asp Thr Ser 
                85                  90                  95      


Asn His Thr Thr Ala Trp Leu Gly Pro Asn Leu Val Pro Glu Met Lys 
            100                 105                 110         


Glu Met Ile Leu Gln Asp Pro His Pro Gln Met Met Gln Leu Pro Trp 
        115                 120                 125             


Thr Thr Gln Ala Leu Asp Ile Met Leu Met Glu Thr Thr Gln Lys Ala 
    130                 135                 140                 


Glu Gln Ile Leu Leu Gln Thr Gln Thr Leu Phe Thr Pro Asp Asn Leu 
145                 150                 155                 160 


Phe Leu Ala Ile Leu Ser Asp Ala Lys Pro Glu His Asn Cys Asn His 
                165                 170                 175     


Cys Ala Cys Gln Ala Cys His Cys Ala His Leu Cys Ala Thr Ser Ile 
            180                 185                 190         


Asn Lys Thr 
        195 


<210>  4828
<211>  548
<212>  DNA
<213>  Homosapiens

<400>  4828
aagaaaaggc tctcttcctc ggcgctgcct acggaggtgg cagccatctc ctcctcggca     60

tcatggccgc cctcagaccc cttgtgaagc ccaagatcgt caaaaagaga accaagaagt    120

tcatccagca ccagtcagac caatatgtca aaattaagcg taactggcgg aaacccagag    180

gcactgacaa cagggttcgt agaagattca agggccagat cttgatgccc aacattggtt    240

atgggagcaa caaaaaaaca aagcacatgc tgcccagtgg cttccggaag ttcctggtcc    300

acaacatcaa ggagctggaa gtgctgctga tgtgcaacaa atcttactgt gccgagatcg    360

ctcacaatgt ttcctccaag aaccgcaaag ccatcgtgga aacagctgcc caactggcca    420

tcagagtcac caaccccaat gccaggctgc gcagcgaaga aaatgagtag acagctcgtg    480

tgcacgtttt ctgtttaaat aaatgtaaaa actgcaaaaa aaaaaaaaaa aaaaaagaaa    540

agaaaact                                                             548


<210>  4829
<211>  135
<212>  PRT
<213>  Homosapiens

<400>  4829

Met Ala Ala Leu Arg Pro Leu Val Lys Pro Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Thr Lys Lys Phe Ile Gln His Gln Ser Asp Gln Tyr Val Lys Ile Lys 
            20                  25                  30          


Arg Asn Trp Arg Lys Pro Arg Gly Thr Asp Asn Arg Val Arg Arg Arg 
        35                  40                  45              


Phe Lys Gly Gln Ile Leu Met Pro Asn Ile Gly Tyr Gly Ser Asn Lys 
    50                  55                  60                  


Lys Thr Lys His Met Leu Pro Ser Gly Phe Arg Lys Phe Leu Val His 
65                  70                  75                  80  


Asn Ile Lys Glu Leu Glu Val Leu Leu Met Cys Asn Lys Ser Tyr Cys 
                85                  90                  95      


Ala Glu Ile Ala His Asn Val Ser Ser Lys Asn Arg Lys Ala Ile Val 
            100                 105                 110         


Glu Thr Ala Ala Gln Leu Ala Ile Arg Val Thr Asn Pro Asn Ala Arg 
        115                 120                 125             


Leu Arg Ser Glu Glu Asn Glu 
    130                 135 


<210>  4830
<211>  548
<212>  DNA
<213>  Homosapiens

<400>  4830
aagaaaaggc tctcttcctc ggcgctgcct acggaggtgg cagccatctc ctcctcggca     60

tcatggccgc cctcagaccc cttgtgaagc ccaagatcgt caaaaagaga accaagaagt    120

tcatccagca ccagtcagac caatatgtca aaattaagcg taactggcgg aaacccagag    180

gcactgacaa cagggttcgt agaagattca agggccagat cttgatgccc aacattggtt    240

atgggagcaa caaaaaaaca aagcacatgc tgcccagtgg cttccggaag ttcctggtcc    300

acaacatcaa ggagctggaa gtgctgctga tgtgcaacaa atcttactgt gccgagatcg    360

ctcacaatgt ttcctccaag aaccgcaaag ccatcgtgga aacagctgcc caactggcca    420

tcagagtcac caaccccaat gccaggctgc gcagcgaaga aaatgagtag acagctcgtg    480

tgcacgtttt ctgtttaaat aaatgtaaaa actgcaaaaa aaaaaaaaaa aaaaaagaaa    540

agaaaact                                                             548


<210>  4831
<211>  135
<212>  PRT
<213>  Homosapiens

<400>  4831

Met Ala Ala Leu Arg Pro Leu Val Lys Pro Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Thr Lys Lys Phe Ile Gln His Gln Ser Asp Gln Tyr Val Lys Ile Lys 
            20                  25                  30          


Arg Asn Trp Arg Lys Pro Arg Gly Thr Asp Asn Arg Val Arg Arg Arg 
        35                  40                  45              


Phe Lys Gly Gln Ile Leu Met Pro Asn Ile Gly Tyr Gly Ser Asn Lys 
    50                  55                  60                  


Lys Thr Lys His Met Leu Pro Ser Gly Phe Arg Lys Phe Leu Val His 
65                  70                  75                  80  


Asn Ile Lys Glu Leu Glu Val Leu Leu Met Cys Asn Lys Ser Tyr Cys 
                85                  90                  95      


Ala Glu Ile Ala His Asn Val Ser Ser Lys Asn Arg Lys Ala Ile Val 
            100                 105                 110         


Glu Thr Ala Ala Gln Leu Ala Ile Arg Val Thr Asn Pro Asn Ala Arg 
        115                 120                 125             


Leu Arg Ser Glu Glu Asn Glu 
    130                 135 


<210>  4832
<211>  552
<212>  DNA
<213>  Homosapiens

<400>  4832
atggcgagca tgcagattgg acctagacat ctagattttg ataatgctat ttttgcagga     60

gtgcatttca aacatacatt gtttgtgaaa gtgtctaatg aaggaagtcc tgtactatca    120

acaattatta cagtcattgt aagggtgagt cgcataaatg aactgaatcc aattggaagt    180

gcgtcagcat ttaccttcag tgtatttgaa aatagtccag ttgatacact agttggaaaa    240

gttacattta ccgatgcaga ctggccattt aataatatgg aatataccat tgttggaggc    300

aatttgggaa cacctcccaa attttacatt gaaccagata caggagtgat aaagctatta    360

gattcactaa acagagaaat tgaatcacag tacaagatag ctgtaaaagt aacagacttg    420

gacaacgatg ccatccctga ccccctcaga cagagaagtg gtactgctca ggtgaccatc    480

agtgttctgg ggccctctga tccatccaga aaaccaggca ttaagaaaga caaatttgaa    540

actgaagttt ga                                                        552


<210>  4833
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  4833

Met Ala Ser Met Gln Ile Gly Pro Arg His Leu Asp Phe Asp Asn Ala 
1               5                   10                  15      


Ile Phe Ala Gly Val His Phe Lys His Thr Leu Phe Val Lys Val Ser 
            20                  25                  30          


Asn Glu Gly Ser Pro Val Leu Ser Thr Ile Ile Thr Val Ile Val Arg 
        35                  40                  45              


Val Ser Arg Ile Asn Glu Leu Asn Pro Ile Gly Ser Ala Ser Ala Phe 
    50                  55                  60                  


Thr Phe Ser Val Phe Glu Asn Ser Pro Val Asp Thr Leu Val Gly Lys 
65                  70                  75                  80  


Val Thr Phe Thr Asp Ala Asp Trp Pro Phe Asn Asn Met Glu Tyr Thr 
                85                  90                  95      


Ile Val Gly Gly Asn Leu Gly Thr Pro Pro Lys Phe Tyr Ile Glu Pro 
            100                 105                 110         


Asp Thr Gly Val Ile Lys Leu Leu Asp Ser Leu Asn Arg Glu Ile Glu 
        115                 120                 125             


Ser Gln Tyr Lys Ile Ala Val Lys Val Thr Asp Leu Asp Asn Asp Ala 
    130                 135                 140                 


Ile Pro Asp Pro Leu Arg Gln Arg Ser Gly Thr Ala Gln Val Thr Ile 
145                 150                 155                 160 


Ser Val Leu Gly Pro Ser Asp Pro Ser Arg Lys Pro Gly Ile Lys Lys 
                165                 170                 175     


Asp Lys Phe Glu Thr Glu Val 
            180             


<210>  4834
<211>  552
<212>  DNA
<213>  Homosapiens

<400>  4834
atggcgagca tgcagattgg acctagacat ctagattttg ataatgctat ttttgcagga     60

gtgcatttca aacatacatt gtttgtgaaa gtgtctaatg aaggaagtcc tgtactatca    120

acaattatta cagtcattgt aagggtgagt cgcataaatg aactgaatcc aattggaagt    180

gcgtcagcat ttaccttcag tgtatttgaa aatagtccag ttgatacact agttggaaaa    240

gttacattta ccgatgcaga ctggccattt aataatatgg aatataccgt tgttggaggc    300

aatttgggaa cacctcccaa attttacatt gaaccagata caggagtgat aaagctatta    360

gattcactaa acagagaaat tgaatcacag tacaagatag ctgtaaaagt aacagacttg    420

gacaacgatg ccatccctga ccccctcaga cagagaagtg gtactgctca ggtgaccatc    480

agtgttctgg ggccctctga tccatccaga aaaccaggca ttaagaaaga caaatttgaa    540

actgaagttt ga                                                        552


<210>  4835
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  4835

Met Ala Ser Met Gln Ile Gly Pro Arg His Leu Asp Phe Asp Asn Ala 
1               5                   10                  15      


Ile Phe Ala Gly Val His Phe Lys His Thr Leu Phe Val Lys Val Ser 
            20                  25                  30          


Asn Glu Gly Ser Pro Val Leu Ser Thr Ile Ile Thr Val Ile Val Arg 
        35                  40                  45              


Val Ser Arg Ile Asn Glu Leu Asn Pro Ile Gly Ser Ala Ser Ala Phe 
    50                  55                  60                  


Thr Phe Ser Val Phe Glu Asn Ser Pro Val Asp Thr Leu Val Gly Lys 
65                  70                  75                  80  


Val Thr Phe Thr Asp Ala Asp Trp Pro Phe Asn Asn Met Glu Tyr Thr 
                85                  90                  95      


Val Val Gly Gly Asn Leu Gly Thr Pro Pro Lys Phe Tyr Ile Glu Pro 
            100                 105                 110         


Asp Thr Gly Val Ile Lys Leu Leu Asp Ser Leu Asn Arg Glu Ile Glu 
        115                 120                 125             


Ser Gln Tyr Lys Ile Ala Val Lys Val Thr Asp Leu Asp Asn Asp Ala 
    130                 135                 140                 


Ile Pro Asp Pro Leu Arg Gln Arg Ser Gly Thr Ala Gln Val Thr Ile 
145                 150                 155                 160 


Ser Val Leu Gly Pro Ser Asp Pro Ser Arg Lys Pro Gly Ile Lys Lys 
                165                 170                 175     


Asp Lys Phe Glu Thr Glu Val 
            180             


<210>  4836
<211>  4351
<212>  DNA
<213>  Homosapiens

<400>  4836
ctggagaggt tttgcaacag ggccaagatc tcacagtgtt cctctcttta agtggggtct     60

aggagaaacc cagatttccc tcaacagata atcattgtaa ctatcaatgg cacgcccgga    120

agctatgctg tcattctgaa tagatctgtt tgacttatca cttaaaagta agtgttttca    180

cacattaaaa cagaaattca gattttaatt aacccagtga atttgcctga aaatatgctc    240

cctggaacac aactaagtcg tgcttatgat aaagatgtgg ctggaaaggg agatgtctac    300

cgttttctga ataaaacata agattttgcc atcgatgcaa gttctggtgt aatcactgct    360

accaaaattt ttaattatga aacagatcca ataaggtttc ttctgattgt tgatactggg    420

aggctctata gacatgtttt gaccattaat attattgatg ttcccgaatc tccaaactgt    480

actgctgatc ccaaattttc ttcaggcaca gttggagaga atgaagaaac aaaatcatat    540

gggattgcaa gagttgggtc tgctggattt ctttttaaag ggagacatga gtaattttac    600

aacatggaga atccatttga tgaggaggct gaagacaaat aaagttttcc accttatact    660

gaaagcaaca gatacaacag gccatttcct ttggattcta ttaatgtgac tgagaagaaa    720

tctgttggag aaattatagc aagagtaaaa gcaacagatc gagatgaaga tagcagtatc    780

atttattcct ttaagactca gcagaaaatg ttttgtttgg accccttcac aggaacaatc    840

actcttcttc agcctttgaa tcttgacaac ccaagtaact ccaaaatcta ctctttggaa    900

actgaggcaa cagataatgg gaataatacc agcagctata cgtttacagt ttttgtggag    960

aatgtagatg atcctatttc ctgtgatcca agtttttcaa caggagcagt cttccaaaat   1020

tatagtaaac tttaaaaaga tacacgtgga tctcaagaag gtcattttga cccgatttct   1080

actacaagct tggctgaacc agcataaact gctagagcag taccaagatc gggatgtctt   1140

cctcttccat catctgggct gtgggccttg ggacataaga gaagcgagga caagaagtca   1200

ctttctgttt aaagtagggc aactctgtgg gtctctgtga ccaagaatta ccaaagacat   1260

tgacatgatt ttcaagctgc tgatttgaca cacacatatt caattcattt actgggttta   1320

attatccagt tgctataatt aaccagaaca aatcactaaa ttagagaatc tgcctacaca   1380

tgttcagttt gaaacaaagg ttcaaaataa gcaagtccta gtcgcaccaa agttgttcta   1440

taacatcctt agaaagtcct gtaaagagac ccttacagga ctacccagtc tagattgtga   1500

tacaatattc actggatttg atatccaaga ttcagctgca cagtaaacat taagcctttt   1560

ttcttttaaa aaaaagtatt cgtagaatca cataacaggt aaagaaacta tcagtagtct   1620

aaatgtgcat ttatgttatt tgattttggg attacacaga atcatagttg gtagcattgg   1680

aaggaggatg aggggcgatg gttggaaaaa ggcaagtagc atttgttgag catttgagag   1740

atgtgttatg tatagtattc tatttaatct ctaaaactac tctaagattg gagaagtact   1800

ttatccccat tgtacaggtg agaatagtga tggagcagga attcaagtgc atttcttcct   1860

gtcttcacag gctgtgctct acttttttgt acatgattgt gaaaggagac aaaaagcttc   1920

aatatcctaa tataaaagaa taaaagtaga aatcatatct tagtggccat tgactttgag   1980

caattatatc ccattctata cagtagccca aagtttaaag gtaggaatat caacctgaat   2040

tatgatggct cttttaaatg ttgatgttaa tgggagtaag tatttgtagg ggttttttgt   2100

ttctctgaaa caaatatgaa gaagatcatt ttaaggaaaa tacagcatgg taatttacgg   2160

taccagcatg aagcaagaag tgaaagaaag acatttgaat ttaaattatt gttcatgatt   2220

gtgtaattgt ataggtgttt cagtgtctgt tcctgaaaac attcctgcat ctacttttat   2280

atatatgatt ctttcaagag atccagatct aggacaggaa gttgaagtaa gtttttttat   2340

tttcatctat ttatttttgc ccaacttgga tgagaaaaaa aacccaaaag agtgctcaat   2400

ttttaatgca caaaatatta ttttgccagg ctgttaatta aagtattctt tatgtgtatg   2460

gtagtcactg aagtgagaga ggagacttaa acctttggga ctagtaacat agaattaaaa   2520

tgctctggct tcaaaatgaa agaaacagat ttcaaatggt ctgaaagcat tgtgaaaaac   2580

tagagcttac atctattggc atttatctga tgacatttac gagcatgaat agaatgttct   2640

ttcattgttc attgcctttt attcatccca atcaggcata ttttctttat tatacataca   2700

atgtgagtaa aggatatttt aggccttcat attaattctg gttttagcaa taattcataa   2760

agaggagaga ataaatttta ggtgacaaaa tggttacagc ttaagtgggg gtaaagaaga   2820

aatttaagat aattcatcac tgtgtatttt ctcagaaatt tttctggtat acatatgacc   2880

tttaatctaa ttatatttgt aagaaaaaaa ttgttttctt gatgatgcaa tatatcataa   2940

atctgattaa tacactggaa tactctgccc gaaatttagt gagtcaaatt ctccatagaa   3000

gagactaact tttttttctg tttgttcatg cttgctataa agatacacat aaatatcact   3060

tgggaatatg gttgaaacta aagtttggga gaaagctctg tggagaattt agtctatatg   3120

taatttttct ggttacctga ttataatgag atattgatta atccacttga ttacattttt   3180

tgctcatgtg aatttcagac tgaggacaga ttacaacaca ggaacaatgt aattcctggc   3240

atatcaggtt cagctcatct atttgtgtga atgtgttagt gtgtgtgttg ggaggataga   3300

gttaggatat tggggtacgt gggtgtgtgc atttaaacta gaatatgtcc atatgtgtga   3360

aggatgggtg tctacaaaag tatccattat aattatgtgc ttacatgcat agtttccatt   3420

accaaaaatt aatgtaatat ctagatttta ttgtaaaagt cattaggaaa gagaaaacaa   3480

acatttggaa aatgatgatg tttaacaaat ctaaaaccat aataatgggg gaaaacaaag   3540

agattatttt cataaggaca tttaagagga ttttagtcta atataagcca acttttgttg   3600

ttcacttaca ggcaaatgaa agatggttaa tatgaccatc aaaatggcta ttatgcattc   3660

tttggaaatg gcattgggta tcagatcttc caggttttat tgcagggttt ttttgagctg   3720

gaatctggat gtgagtgttt ataatataat ttctttatga aatccttttc aaaatcttta   3780

atatttgtct tgataacaat ggagagaaac atgccgatgc ccataaaaat aatagctttg   3840

tccaaggcaa tattttattt ttgccatgca gaaaatcaat tcagagatgg aatcaaacgg   3900

cttcttccaa ataattcagt tcatgtgcct cctttagata tacttcctga gtattcaaga   3960

gggaacagct tttttttaat attggaaaaa tctgtaaatg caacactaga aagtaaacta   4020

attatgaaat tattgaaagc tattcaccaa aaatgctcta atattttagt ataaaatgca   4080

ttggaaaaaa atacaactaa aacgtgaaag aatatataga ttatttttga agtctggaac   4140

tgaaagtaag ttcagatttt aatttatagg cagtcttcgc aaaatttatt ttggtttaca   4200

tcttgccaaa tcgttgcatc aaagctgtca gttcagaatt catgcttact caataatgta   4260

ttaaccatgt ttgtgtgtgt atgtgtgtgt tgcagttttt aatattaaat tcttcaatta   4320

atgccactgc ctactttgct ttggattcgc a                                  4351


<210>  4837
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  4837

Met Phe Cys Leu Asp Pro Phe Thr Gly Thr Ile Thr Leu Leu Gln Pro 
1               5                   10                  15      


Leu Asn Leu Asp Asn Pro Ser Asn Ser Lys Ile Tyr Ser Leu Glu Thr 
            20                  25                  30          


Glu Ala Thr Asp Asn Gly Asn Asn Thr Ser Ser Tyr Thr Phe Thr Val 
        35                  40                  45              


Phe Val Glu Asn Val Asp Asp Pro Ile Ser Cys Asp Pro Ser Phe Ser 
    50                  55                  60                  


Thr Gly Ala Val Phe Gln Asn Tyr Ser Lys Leu 
65                  70                  75  


<210>  4838
<211>  4637
<212>  DNA
<213>  Homosapiens

<400>  4838
ttgcccaaag ctctttgaga tgtcaactaa aggaacatgg cctcctcatc tctaaataca     60

cctggctaac agtaactatc aatggcacgc ccggaagcta tgctgtcatt ctgaatagat    120

ctgtttgact tatcacttaa aagtaagact cagataactg aaatgacctg aagagatggt    180

atttcagaat atttgggtga ccacatttat ttgttatgtg ttttcacaca ttaaaacaga    240

aattcagatt ttaattaacc cagtgaattt gcctgaaaat atgctccctg gaacacaact    300

aagtcgtgct tatgataaag atgtggctgg aaagggagat gtctaccgtt ttctgaataa    360

aacataagat tttgccatcg atgcaagttc tggtgtaatc actgctacca aaatttttaa    420

ttatgaaaca gatccaataa ggtttcttct gattgttgat actgggaggc tctatagaca    480

tgttttgacc attaatatta ttgatgttcc cgaatctcca aactgtactg ctgatcccaa    540

attttcttca ggcacagttg gagagaatga agaaacaaaa tcatatggga ttgcaagagt    600

tgggtctgct ggatttcttt ttaaagggag acatgagtaa ttttacaaca tggagaatcc    660

atttgatgag gaggctgaag acaaataaag tagtacacca ttgagacaca gttatctgga    720

ccaaagaaag gagcaaactc ttttggaacg gatcctataa gtgatgttgt tagattaaga    780

ggtgaagatc ccctggattt ggatactgga tatcatgcca tttcctttgg attctattaa    840

tgtgactgag aagaaatctg ttggagaaat tatagcaaga gtaaaagcaa cagatcgaga    900

tgaagatagc agtatcattt attcctttaa gactcagcag aaaatgtttt gtttggaccc    960

ctaagctgag cctttcatca cgtggctgag tatacagacc tgttctaaga gtcagagaag   1020

ctgaaagaag atccagcagt aggtcaagca atttcagatt tagctgaagc tagttcacac   1080

caacagtaac acagcagatc aacaaaaaca tggtcacagg aacaatcact cttcttcagc   1140

ctttgaatct tgacaaccca agtaactcca aaatctactc tttggaaact gaggcaacag   1200

ataatgggaa taataccagc agctatacgt ttacagtttt tgtggagaat gtagatgatc   1260

ctatttcctg tgatccaagt ttttcaacag gagcagtctt ccaaaattat agtaaacttt   1320

aaaaagatac acgtggatct caagaaggtc attttgaccc gatttctact acaagcttgg   1380

ctgaaccagc ataaactgct agagcagtac caagatcggg atgtcttcct cttccatcat   1440

ctgggctgtg ggccttggga cataagagaa gcgaggacaa gaagtcactt tctgtttaaa   1500

gtagggcaac tctgtgggtc tctgtgacca agaattacca aagacattga catgattttc   1560

aagctgctga tttgacacac acatattcaa ttcatttact gggtttaatt atccagttgc   1620

tataattaac cagaacaaat cactaaatta gagaatctgc ctacacatgt tcagtttgaa   1680

acaaaggttc aaaataagca agtcctagtc gcaccaaagt tgttctataa catccttaga   1740

aagtcctgta aagagaccct tacaggacta cccagtctag attgtgatac aatattcact   1800

ggatttgata tccaagattc agctgcacag taaacattaa gccttttttc ttttaaaaaa   1860

aagtattcgt agaatcacat aacaggtaaa gaaactatca gtagtctaaa tgtgcattta   1920

tgttatttga ttttgggatt acacagaatc atagttggta gcattggaag gaggatgagg   1980

ggcgatggtt ggaaaaaggc aagtagcatt tgttgagcat ttgagagatg tgttatgtat   2040

agtattctat ttaatctcta aaactactct aagattggag aagtacttta tccccattgt   2100

acaggtgaga atagtgatgg agcaggaatt caagtgcatt tcttcctgtc ttcacaggct   2160

gtgctctact tttttgtaca tgattgtgaa aggagacaaa aagcttcaat atcctaatat   2220

aaaagaataa aagtagaaat catatcttag tggccattga ctttgagcaa ttatatccca   2280

ttctatacag tagcccaaag tttaaaggta ggaatatcaa cctgaattat gatggctctt   2340

ttaaatgttg atgttaatgg gagtaagtat ttgtaggggt tttttgtttc tctgaaacaa   2400

atatgaagaa gatcatttta aggaaaatac agcatggtaa tttacggtac cagcatgaag   2460

caagaagtga aagaaagaca tttgaattta aattattgtt catgattgtg taattgtata   2520

ggtgtttcag tgtctgttcc tgaaaacatt cctgcatcta cttttatata tatgattctt   2580

tcaagagatc cagatctagg acaggaagtt gaagtaagtt tttttatttt catctattta   2640

tttttgccca acttggatga gaaaaaaaac ccaaaagagt gctcaatttt taatgcacaa   2700

aatattattt tgccaggctg ttaattaaag tattctttat gtgtatggta gtcactgaag   2760

tgagagagga gacttaaacc tttgggacta gtaacataga attaaaatgc tctggcttca   2820

aaatgaaaga aacagatttc aaatggtctg aaagcattgt gaaaaactag agcttacatc   2880

tattggcatt tatctgatga catttacgag catgaataga atgttctttc attgttcatt   2940

gccttttatt catcccaatc aggcatattt tctttattat acatacaatg tgagtaaagg   3000

atattttagg ccttcatatt aattctggtt ttagcaataa ttcataaaga ggagagaata   3060

aattttaggt gacaaaatgg ttacagctta agtgggggta aagaagaaat ttaagataat   3120

tcatcactgt gtattttctc agaaattttt ctggtataca tatgaccttt aatctaatta   3180

tatttgtaag aaaaaaattg ttttcttgat gatgcaatat atcataaatc tgattaatac   3240

actggaatac tctgcccgaa atttagtgag tcaaattctc catagaagag actaactttt   3300

ttttctgttt gttcatgctt gctataaaga tacacataaa tatcacttgg gaatatggtt   3360

gaaactaaag tttgggagaa agctctgtgg agaatttagt ctatatgtaa tttttctggt   3420

tacctgatta taatgagata ttgattaatc cacttgatta cattttttgc tcatgtgaat   3480

ttcagactga ggacagatta caacacagga acaatgtaat tcctggcata tcaggttcag   3540

ctcatctatt tgtgtgaatg tgttagtgtg tgtgttggga ggatagagtt aggatattgg   3600

ggtacgtggg tgtgtgcatt taaactagaa tatgtccata tgtgtgaagg atgggtgtct   3660

acaaaagtat ccattataat tatgtgctta catgcatagt ttccattacc aaaaattaat   3720

gtaatatcta gattttattg taaaagtcat taggaaagag aaaacaaaca tttggaaaat   3780

gatgatgttt aacaaatcta aaaccataat aatgggggaa aacaaagaga ttattttcat   3840

aaggacattt aagaggattt tagtctaata taagccaact tttgttgttc acttacaggc   3900

aaatgaaaga tggttaatat gaccatcaaa atggctatta tgcattcttt ggaaatggca   3960

ttgggtatca gatcttccag gttttattgc agggtttttt tgagctggaa tctggatgtg   4020

agtgtttata atataatttc tttatgaaat ccttttcaaa atctttaata tttgtcttga   4080

taacaatgga gagaaacatg ccgatgccca taaaaataat agctttgtcc aaggcaatat   4140

tttatttttg ccatgcagaa aatcaattca gagatggaat caaacggctt cttccaaata   4200

attcagttca tgtgcctcct ttagatatac ttcctgagta ttcaagaggg aacagctttt   4260

ttttaatatt ggaaaaatct gtaaatgcaa cactagaaag taaactaatt atgaaattat   4320

tgaaagctat tcaccaaaaa tgctctaata ttttagtata aaatgcattg gaaaaaaata   4380

caactaaaac gtgaaagaat atatagatta tttttgaagt ctggaactga aagtaagttc   4440

agattttaat ttataggcag tcttcgcaaa atttattttg gtttacatct tgccaaatcg   4500

ttgcatcaaa gctgtcagtt cagaattcat gcttactcaa taatgtatta accatgtttg   4560

tgtgtgtatg tgtgtgttgc agtttttaat attaaattct tcaattaatg ccactgccta   4620

ctttgctttg gattcgc                                                  4637


<210>  4839
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  4839

Met Val Thr Gly Thr Ile Thr Leu Leu Gln Pro Leu Asn Leu Asp Asn 
1               5                   10                  15      


Pro Ser Asn Ser Lys Ile Tyr Ser Leu Glu Thr Glu Ala Thr Asp Asn 
            20                  25                  30          


Gly Asn Asn Thr Ser Ser Tyr Thr Phe Thr Val Phe Val Glu Asn Val 
        35                  40                  45              


Asp Asp Pro Ile Ser Cys Asp Pro Ser Phe Ser Thr Gly Ala Val Phe 
    50                  55                  60                  


Gln Asn Tyr Ser Lys Leu 
65                  70  


<210>  4840
<211>  4351
<212>  DNA
<213>  Homosapiens

<400>  4840
ctggagaggt tttgcaacag ggccaagatc tcacagtgtt cctctcttta agtggggtct     60

aggagaaacc cagatttccc tcaacagata atcattgtaa ctatcaatgg cacgcccgga    120

agctatgctg tcattctgaa tagatctgtt tgacttatca cttaaaagta agtgttttca    180

cacattaaaa cagaaattca gattttaatt aacccagtga atttgcctga aaatatgctc    240

cctggaacac aactaagtcg tgcttatgat aaagatgtgg ctggaaaggg agatgtctac    300

cgttttctga ataaaacata agattttgcc atcgatgcaa gttctggtgt aatcactgct    360

accaaaattt ttaattatga aacagatcca ataaggtttc ttctgattgt tgatactggg    420

aggctctata gacatgtttt gaccattaat attattgatg ttcccgaatc tccaaactgt    480

actgctgatc ccaaattttc ttcaggcaca gttggagaga atgaagaaac aaaatcatat    540

gggattgcaa gagttgagtc tgctggattt ctttttaaag ggagacatga gtaattttac    600

aacatggaga atccatttga tgaggaggct gaagacaaat aaagttttcc accttatact    660

gaaagcaaca gatacaacag gccatttcct ttggattcta ttaatgtgac tgagaagaaa    720

tctgttggag aaattatagc aagagtaaaa gcaacagatc gagatgaaga tagcagtatc    780

atttattcct ttaagactca gcagaaaatg ttttgtttgg accccttcac aggaacaatc    840

actcttcttc agcctttgaa tcttgacaac ccaagtaact ccaaaatcta ctctttggaa    900

actgaggcaa cagataatgg gaataatacc agcagctata cgtttacagt ttttgtggag    960

aatgtagatg atcctatttc ctgtgatcca agtttttcaa caggagcagt cttccaaaat   1020

tatagtaaac tttaaaaaga tacacgtgga tctcaagaag gtcattttga cccgatttct   1080

actacaagct tggctgaacc agcataaact gctagagcag taccaagatc gggatgtctt   1140

cctcttccat catctgggct gtgggccttg ggacataaga gaagcgagga caagaagtca   1200

ctttctgttt aaagtagggc aactctgtgg gtctctgtga ccaagaatta ccaaagacat   1260

tgacatgatt ttcaagctgc tgatttgaca cacacatatt caattcattt actgggttta   1320

attatccagt tgctataatt aaccagaaca aatcactaaa ttagagaatc tgcctacaca   1380

tgttcagttt gaaacaaagg ttcaaaataa gcaagtccta gtcgcaccaa agttgttcta   1440

taacatcctt agaaagtcct gtaaagagac ccttacagga ctacccagtc tagattgtga   1500

tacaatattc actggatttg atatccaaga ttcagctgca cagtaaacat taagcctttt   1560

ttcttttaaa aaaaagtatt cgtagaatca cataacaggt aaagaaacta tcagtagtct   1620

aaatgtgcat ttatgttatt tgattttggg attacacaga atcatagttg gtagcattgg   1680

aaggaggatg aggggcgatg gttggaaaaa ggcaagtagc atttgttgag catttgagag   1740

atgtgttatg tatagtattc tatttaatct ctaaaactac tctaagattg gagaagtact   1800

ttatccccat tgtacaggtg agaatagtga tggagcagga attcaagtgc atttcttcct   1860

gtcttcacag gctgtgctct acttttttgt acatgattgt gaaaggagac aaaaagcttc   1920

aatatcctaa tataaaagaa taaaagtaga aatcatatct tagtggccat tgactttgag   1980

caattatatc ccattctata cagtagccca aagtttaaag gtaggaatat caacctgaat   2040

tatgatggct cttttaaatg ttgatgttaa tgggagtaag tatttgtagg ggttttttgt   2100

ttctctgaaa caaatatgaa gaagatcatt ttaaggaaaa tacagcatgg taatttacgg   2160

taccagcatg aagcaagaag tgaaagaaag acatttgaat ttaaattatt gttcatgatt   2220

gtgtaattgt ataggtgttt cagtgtctgt tcctgaaaac attcctgcat ctacttttat   2280

atatatgatt ctttcaagag atccagatct aggacaggaa gttgaagtaa gtttttttat   2340

tttcatctat ttatttttgc ccaacttgga tgagaaaaaa aacccaaaag agtgctcaat   2400

ttttaatgca caaaatatta ttttgccagg ctgttaatta aagtattctt tatgtgtatg   2460

gtagtcactg aagtgagaga ggagacttaa acctttggga ctagtaacat agaattaaaa   2520

tgctctggct tcaaaatgaa agaaacagat ttcaaatggt ctgaaagcat tgtgaaaaac   2580

tagagcttac atctattggc atttatctga tgacatttac gagcatgaat agaatgttct   2640

ttcattgttc attgcctttt attcatccca atcaggcata ttttctttat tatacataca   2700

atgtgagtaa aggatatttt aggccttcat attaattctg gttttagcaa taattcataa   2760

agaggagaga ataaatttta ggtgacaaaa tggttacagc ttaagtgggg gtaaagaaga   2820

aatttaagat aattcatcac tgtgtatttt ctcagaaatt tttctggtat acatatgacc   2880

tttaatctaa ttatatttgt aagaaaaaaa ttgttttctt gatgatgcaa tatatcataa   2940

atctgattaa tacactggaa tactctgccc gaaatttagt gagtcaaatt ctccatagaa   3000

gagactaact tttttttctg tttgttcatg cttgctataa agatacacat aaatatcact   3060

tgggaatatg gttgaaacta aagtttggga gaaagctctg tggagaattt agtctatatg   3120

taatttttct ggttacctga ttataatgag atattgatta atccacttga ttacattttt   3180

tgctcatgtg aatttcagac tgaggacaga ttacaacaca ggaacaatgt aattcctggc   3240

atatcaggtt cagctcatct atttgtgtga atgtgttagt gtgtgtgttg ggaggataga   3300

gttaggatat tggggtacgt gggtgtgtgc atttaaacta gaatatgtcc atatgtgtga   3360

aggatgggtg tctacaaaag tatccattat aattatgtgc ttacatgcat agtttccatt   3420

accaaaaatt aatgtaatat ctagatttta ttgtaaaagt cattaggaaa gagaaaacaa   3480

acatttggaa aatgatgatg tttaacaaat ctaaaaccat aataatgggg gaaaacaaag   3540

agattatttt cataaggaca tttaagagga ttttagtcta atataagcca acttttgttg   3600

ttcacttaca ggcaaatgaa agatggttaa tatgaccatc aaaatggcta ttatgcattc   3660

tttggaaatg gcattgggta tcagatcttc caggttttat tgcagggttt ttttgagctg   3720

gaatctggat gtgagtgttt ataatataat ttctttatga aatccttttc aaaatcttta   3780

atatttgtct tgataacaat ggagagaaac atgccgatgc ccataaaaat aatagctttg   3840

tccaaggcaa tattttattt ttgccatgca gaaaatcaat tcagagatgg aatcaaacgg   3900

cttcttccaa ataattcagt tcatgtgcct cctttagata tacttcctga gtattcaaga   3960

gggaacagct tttttttaat attggaaaaa tctgtaaatg caacactaga aagtaaacta   4020

attatgaaat tattgaaagc tattcaccaa aaatgctcta atattttagt ataaaatgca   4080

ttggaaaaaa atacaactaa aacgtgaaag aatatataga ttatttttga agtctggaac   4140

tgaaagtaag ttcagatttt aatttatagg cagtcttcgc aaaatttatt ttggtttaca   4200

tcttgccaaa tcgttgcatc aaagctgtca gttcagaatt catgcttact caataatgta   4260

ttaaccatgt ttgtgtgtgt atgtgtgtgt tgcagttttt aatattaaat tcttcaatta   4320

atgccactgc ctactttgct ttggattcgc a                                  4351


<210>  4841
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  4841

Met Phe Cys Leu Asp Pro Phe Thr Gly Thr Ile Thr Leu Leu Gln Pro 
1               5                   10                  15      


Leu Asn Leu Asp Asn Pro Ser Asn Ser Lys Ile Tyr Ser Leu Glu Thr 
            20                  25                  30          


Glu Ala Thr Asp Asn Gly Asn Asn Thr Ser Ser Tyr Thr Phe Thr Val 
        35                  40                  45              


Phe Val Glu Asn Val Asp Asp Pro Ile Ser Cys Asp Pro Ser Phe Ser 
    50                  55                  60                  


Thr Gly Ala Val Phe Gln Asn Tyr Ser Lys Leu 
65                  70                  75  


<210>  4842
<211>  4637
<212>  DNA
<213>  Homosapiens

<400>  4842
ttgcccaaag ctctttgaga tgtcaactaa aggaacatgg cctcctcatc tctaaataca     60

cctggctaac agtaactatc aatggcacgc ccggaagcta tgctgtcatt ctgaatagat    120

ctgtttgact tatcacttaa aagtaagact cagataactg aaatgacctg aagagatggt    180

atttcagaat atttgggtga ccacatttat ttgttatgtg ttttcacaca ttaaaacaga    240

aattcagatt ttaattaacc cagtgaattt gcctgaaaat atgctccctg gaacacaact    300

aagtcgtgct tatgataaag atgtggctgg aaagggagat gtctaccgtt ttctgaataa    360

aacataagat tttgccatcg atgcaagttc tggtgtaatc actgctacca aaatttttaa    420

ttatgaaaca gatccaataa ggtttcttct gattgttgat actgggaggc tctatagaca    480

tgttttgacc attaatatta ttgatgttcc cgaatctcca aactgtactg ctgatcccaa    540

attttcttca ggcacagttg gagagaatga agaaacaaaa tcatatggga ttgcaagagt    600

tgagtctgct ggatttcttt ttaaagggag acatgagtaa ttttacaaca tggagaatcc    660

atttgatgag gaggctgaag acaaataaag tagtacacca ttgagacaca gttatctgga    720

ccaaagaaag gagcaaactc ttttggaacg gatcctataa gtgatgttgt tagattaaga    780

ggtgaagatc ccctggattt ggatactgga tatcatgcca tttcctttgg attctattaa    840

tgtgactgag aagaaatctg ttggagaaat tatagcaaga gtaaaagcaa cagatcgaga    900

tgaagatagc agtatcattt attcctttaa gactcagcag aaaatgtttt gtttggaccc    960

ctaagctgag cctttcatca cgtggctgag tatacagacc tgttctaaga gtcagagaag   1020

ctgaaagaag atccagcagt aggtcaagca atttcagatt tagctgaagc tagttcacac   1080

caacagtaac acagcagatc aacaaaaaca tggtcacagg aacaatcact cttcttcagc   1140

ctttgaatct tgacaaccca agtaactcca aaatctactc tttggaaact gaggcaacag   1200

ataatgggaa taataccagc agctatacgt ttacagtttt tgtggagaat gtagatgatc   1260

ctatttcctg tgatccaagt ttttcaacag gagcagtctt ccaaaattat agtaaacttt   1320

aaaaagatac acgtggatct caagaaggtc attttgaccc gatttctact acaagcttgg   1380

ctgaaccagc ataaactgct agagcagtac caagatcggg atgtcttcct cttccatcat   1440

ctgggctgtg ggccttggga cataagagaa gcgaggacaa gaagtcactt tctgtttaaa   1500

gtagggcaac tctgtgggtc tctgtgacca agaattacca aagacattga catgattttc   1560

aagctgctga tttgacacac acatattcaa ttcatttact gggtttaatt atccagttgc   1620

tataattaac cagaacaaat cactaaatta gagaatctgc ctacacatgt tcagtttgaa   1680

acaaaggttc aaaataagca agtcctagtc gcaccaaagt tgttctataa catccttaga   1740

aagtcctgta aagagaccct tacaggacta cccagtctag attgtgatac aatattcact   1800

ggatttgata tccaagattc agctgcacag taaacattaa gccttttttc ttttaaaaaa   1860

aagtattcgt agaatcacat aacaggtaaa gaaactatca gtagtctaaa tgtgcattta   1920

tgttatttga ttttgggatt acacagaatc atagttggta gcattggaag gaggatgagg   1980

ggcgatggtt ggaaaaaggc aagtagcatt tgttgagcat ttgagagatg tgttatgtat   2040

agtattctat ttaatctcta aaactactct aagattggag aagtacttta tccccattgt   2100

acaggtgaga atagtgatgg agcaggaatt caagtgcatt tcttcctgtc ttcacaggct   2160

gtgctctact tttttgtaca tgattgtgaa aggagacaaa aagcttcaat atcctaatat   2220

aaaagaataa aagtagaaat catatcttag tggccattga ctttgagcaa ttatatccca   2280

ttctatacag tagcccaaag tttaaaggta ggaatatcaa cctgaattat gatggctctt   2340

ttaaatgttg atgttaatgg gagtaagtat ttgtaggggt tttttgtttc tctgaaacaa   2400

atatgaagaa gatcatttta aggaaaatac agcatggtaa tttacggtac cagcatgaag   2460

caagaagtga aagaaagaca tttgaattta aattattgtt catgattgtg taattgtata   2520

ggtgtttcag tgtctgttcc tgaaaacatt cctgcatcta cttttatata tatgattctt   2580

tcaagagatc cagatctagg acaggaagtt gaagtaagtt tttttatttt catctattta   2640

tttttgccca acttggatga gaaaaaaaac ccaaaagagt gctcaatttt taatgcacaa   2700

aatattattt tgccaggctg ttaattaaag tattctttat gtgtatggta gtcactgaag   2760

tgagagagga gacttaaacc tttgggacta gtaacataga attaaaatgc tctggcttca   2820

aaatgaaaga aacagatttc aaatggtctg aaagcattgt gaaaaactag agcttacatc   2880

tattggcatt tatctgatga catttacgag catgaataga atgttctttc attgttcatt   2940

gccttttatt catcccaatc aggcatattt tctttattat acatacaatg tgagtaaagg   3000

atattttagg ccttcatatt aattctggtt ttagcaataa ttcataaaga ggagagaata   3060

aattttaggt gacaaaatgg ttacagctta agtgggggta aagaagaaat ttaagataat   3120

tcatcactgt gtattttctc agaaattttt ctggtataca tatgaccttt aatctaatta   3180

tatttgtaag aaaaaaattg ttttcttgat gatgcaatat atcataaatc tgattaatac   3240

actggaatac tctgcccgaa atttagtgag tcaaattctc catagaagag actaactttt   3300

ttttctgttt gttcatgctt gctataaaga tacacataaa tatcacttgg gaatatggtt   3360

gaaactaaag tttgggagaa agctctgtgg agaatttagt ctatatgtaa tttttctggt   3420

tacctgatta taatgagata ttgattaatc cacttgatta cattttttgc tcatgtgaat   3480

ttcagactga ggacagatta caacacagga acaatgtaat tcctggcata tcaggttcag   3540

ctcatctatt tgtgtgaatg tgttagtgtg tgtgttggga ggatagagtt aggatattgg   3600

ggtacgtggg tgtgtgcatt taaactagaa tatgtccata tgtgtgaagg atgggtgtct   3660

acaaaagtat ccattataat tatgtgctta catgcatagt ttccattacc aaaaattaat   3720

gtaatatcta gattttattg taaaagtcat taggaaagag aaaacaaaca tttggaaaat   3780

gatgatgttt aacaaatcta aaaccataat aatgggggaa aacaaagaga ttattttcat   3840

aaggacattt aagaggattt tagtctaata taagccaact tttgttgttc acttacaggc   3900

aaatgaaaga tggttaatat gaccatcaaa atggctatta tgcattcttt ggaaatggca   3960

ttgggtatca gatcttccag gttttattgc agggtttttt tgagctggaa tctggatgtg   4020

agtgtttata atataatttc tttatgaaat ccttttcaaa atctttaata tttgtcttga   4080

taacaatgga gagaaacatg ccgatgccca taaaaataat agctttgtcc aaggcaatat   4140

tttatttttg ccatgcagaa aatcaattca gagatggaat caaacggctt cttccaaata   4200

attcagttca tgtgcctcct ttagatatac ttcctgagta ttcaagaggg aacagctttt   4260

ttttaatatt ggaaaaatct gtaaatgcaa cactagaaag taaactaatt atgaaattat   4320

tgaaagctat tcaccaaaaa tgctctaata ttttagtata aaatgcattg gaaaaaaata   4380

caactaaaac gtgaaagaat atatagatta tttttgaagt ctggaactga aagtaagttc   4440

agattttaat ttataggcag tcttcgcaaa atttattttg gtttacatct tgccaaatcg   4500

ttgcatcaaa gctgtcagtt cagaattcat gcttactcaa taatgtatta accatgtttg   4560

tgtgtgtatg tgtgtgttgc agtttttaat attaaattct tcaattaatg ccactgccta   4620

ctttgctttg gattcgc                                                  4637


<210>  4843
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  4843

Met Val Thr Gly Thr Ile Thr Leu Leu Gln Pro Leu Asn Leu Asp Asn 
1               5                   10                  15      


Pro Ser Asn Ser Lys Ile Tyr Ser Leu Glu Thr Glu Ala Thr Asp Asn 
            20                  25                  30          


Gly Asn Asn Thr Ser Ser Tyr Thr Phe Thr Val Phe Val Glu Asn Val 
        35                  40                  45              


Asp Asp Pro Ile Ser Cys Asp Pro Ser Phe Ser Thr Gly Ala Val Phe 
    50                  55                  60                  


Gln Asn Tyr Ser Lys Leu 
65                  70  


<210>  4844
<211>  4009
<212>  DNA
<213>  Homosapiens

<400>  4844
ggaccaggga aggatatgag gaagtgttct gaggacagaa aaacgggaga atggggagga     60

gaaggagcgg cacatggagc tcagcagagg agacagacag aaggaaagat ggcttggaga    120

agccagcagt ctgcgaggct ggggaggatg gagagtggtt tggggttttg ggtcgggctc    180

tagtgtgatc aactgcagaa gcattacacc gtggcctggt ttctttactc agcccctggg    240

gtagatccca gccccccgca taggtccttt tgctggaaaa ggaagatgga gtggtgggac    300

gaatctgagg agtcgttgga ggaggagcca cggaaggtgc tcgcccctga gcctgaggag    360

atctgggtgg cggagatgct gtgtggcctc aagatgaagc tgaagcgacg gcgagtgtcg    420

ctcgtgctcc ctgagcacca cgaggccttc aacaggctgc ttgaggatcc tgtcattaaa    480

agattcttgg cctgggacaa agatctgagg gtgtcggaca agtatctcct ggctatggtc    540

atagcgtatt tcagccgggc tggcttcccc tcctggcaat accaacgcat tcatttcttc    600

ctggctctct acctggccaa tgacatggag gaggacgacg aggactccaa acaaaacatc    660

ttccacttcc tgtataggaa gaaccgctct cgcataccct tgctccgtaa gcgttggttc    720

cagttaggcc attccatgaa cccgagggcc aggaagaacc gctctcgcat acccttgctc    780

cgtaagcgtc ggttccagtt ataccgttcc acgaacccga gggccaggaa gaaccgctct    840

cgcataccct tgctccgtaa gcgtcggttc cagttatacc gttccatgaa ctcgagggcc    900

aggaagaacc gctctcagat agtcctgttc cagaaacgac ggttccactt cttctgttcc    960

atgagctgca gggcttgggt ttccccagag gagttggagg aggtgagtgg ggcctgggga   1020

ggtggaggag gtggggagga attgggtggg ctggaggctg gatgagggga gagaggggta   1080

tcctggcgag tccccgtctt ctcaaagggc gtttgttttt ccagatccag gcttatgacc   1140

cagagcactg ggtgtgggcg cgagatcgcg ctcacctttc ctagagctcc agggaccggg   1200

gaggcctgag gtcatcggcc tgagagaagg tacatctgca tcctctgggg taaaggcaga   1260

atattggggt ctatttcgga aatccgaaga acccaattgc ttgatctggc ttcaagcctg   1320

ggcaacgtgg cgagatcccc tctccacaaa aatacaaaaa ttagccaggc gatgtgggac   1380

gcatctctac tcccaactac tcaggaggct gaggcgggag gatcgctgga gcctggaagg   1440

tcggggccgc acggagccct gatcctgcca ctgcactcca gtctgggcga cagagtgaga   1500

ccctgcctca aaaataatca taaaaactga gtttggggag gttcattatg attgacgcac   1560

ttgagttact gatttgggtc gagggttcag tgaagctttg gtttacatct tgtgcagcta   1620

accacgttga gcacagagca tgagacttca tcatgaggag gtaggattaa ggattaggct   1680

tctggactcg tggttcgtga tgttgtcaca ttagaaacac atctagcatg gttacaagtt   1740

tagatcttaa gtgacacaaa aggccccagc tgtgataaag tccaaagcca cattctctga   1800

gggtgcccta ctccctgggc agacccaccc aaagtccttg ctatgaagca gatcactggg   1860

gctgaccttg ggtgtattaa gtgagttttg gagtcgtggt caccaaagtg tgagtttcac   1920

agttgaacac gatggttcag aagcagggta tagaatgaaa ggcagcagat aaaattgcat   1980

ttctcaattg acatgggacg tgaataactt tcctgtctag agagctgcct ccttgaagtg   2040

tgacattgtc tctctcgcct ccagaacact ggacccaggg gagatgtgga ttttcagcag   2100

gaactttatt ccaatgctaa tggcagacac caggcaggag gagaggaacc atttgtgcag   2160

atcatctaga agaacctgga ccattcttga tggagctgaa tacagtgatc acgttgtcct   2220

cctaggagca ggggtggggg gaggggggtg gggtccttct aggagtcctt ggagaaaagt   2280

aagaaaccag gagcgtttcc agttccaccc tttcctgcgg caccaccacc ctttttatat   2340

tgctgaattc caacctccct ggggcggaac ctggaggtcc tgtttcttac ggacttgcag   2400

tccaggagga tttgaaggca caatgcaggg gctcagattg ggacagaatt cttttgtgaa   2460

atatcagtgc cacagattgt aacagatagc ttcatgcaca ctctgcattt tattggtttg   2520

tttggaaaat gtcggccatt gaattattca tagatttatt tcaaatagtt tggaaattgt   2580

tgtacttttg aaaacatgct gttcctgtag ttttttgatg agagttatag ttgttatata   2640

tacataaaga taattttctt ttcattttta agagacaatt cttttatcct aaatatttta   2700

ttatctttaa atttgtttct gtattattat atgtgctcct gaagcgagca ctctttttat   2760

ctatgatact tccataataa tctcttctat ttatagctat tggtagttcc ccaccagaaa   2820

aatacataat tctggtgata gaaattttta tttgctgttt aggtttgtga ctgaattgtg   2880

agaattcagt tgtgattttt aacatgtctc agatatatat actaacacgt ctaatatata   2940

ctatctattt tattggttta ttttgaaaaa catgggtata gaattattta aatattattt   3000

tatttattta aatatttatt aaatatattt atttatttaa atattatttt tacattaaat   3060

attattttaa atattttgga aatactggta tttttgaata gatgctgttt ctacaaagct   3120

gtgtgatggg tattataact gttatataca catacatata attttgtttt cctttttaag   3180

agaggattct tttcatccta aatcttttac ctttcaatct ttgtatctat tattacacgt   3240

gctgctgaag ggagcatgga ttttatctat gatacttagt taacatatat attacattta   3300

tagctatgta gtagttcccc taaattcttg taaaaataaa tttttatttg atatttcata   3360

tatgtttgaa atgtgagaat tcagatgtaa ttttttacct tgttttggca tgtttgtata   3420

ttactttaaa gagaatgtgt gttctaaagg aggacatgag ctgtgtgttt tcaagagaac   3480

aatagagtgg gtctcttggg gaaacataat aaaaatgaac ttttctcacc ttcacagcaa   3540

ttgtgatcat attggtctgg attgattatt tgctgcccag tgatattttt ccttaatggg   3600

gttgtggtta tttgaacata tttattagct ctggaagata atcctgtgct gttttttatg   3660

tagaaaaaaa cataaggctg ggtgcagtgc tcacacctac aatccctgcg gttttggagg   3720

tcatggtggg aggatcacct gaggccagga gtttgaggcc agcctcagca acatagcatc   3780

tacatctatt tttaattttt attttttaaa gaaaaacaat agaagagaag gctgatccca   3840

agctacaggg tttttttgtt tgtttgtttg ttttggagac agagtcttgc tctgtctccc   3900

aggctggagt gcagtggcac aacctcggct ccctgcaact ttcacctctg ggttcaaaca   3960

aattctcctg cctcagcctc ccaagtagct gggactacag gcacccgtc               4009


<210>  4845
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  4845

Met Glu Trp Trp Asp Glu Ser Glu Glu Ser Leu Glu Glu Glu Pro Arg 
1               5                   10                  15      


Lys Val Leu Ala Pro Glu Pro Glu Glu Ile Trp Val Ala Glu Met Leu 
            20                  25                  30          


Cys Gly Leu Lys Met Lys Leu Lys Arg Arg Arg Val Ser Leu Val Leu 
        35                  40                  45              


Pro Glu His His Glu Ala Phe Asn Arg Leu Leu Glu Asp Pro Val Ile 
    50                  55                  60                  


Lys Arg Phe Leu Ala Trp Asp Lys Asp Leu Arg Val Ser Asp Lys Tyr 
65                  70                  75                  80  


Leu Leu Ala Met Val Ile Ala Tyr Phe Ser Arg Ala Gly Phe Pro Ser 
                85                  90                  95      


Trp Gln Tyr Gln Arg Ile His Phe Phe Leu Ala Leu Tyr Leu Ala Asn 
            100                 105                 110         


Asp Met Glu Glu Asp Asp Glu Asp Ser Lys Gln Asn Ile Phe His Phe 
        115                 120                 125             


Leu Tyr Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Arg Trp 
    130                 135                 140                 


Phe Gln Leu Gly His Ser Met Asn Pro Arg Ala Arg Lys Asn Arg Ser 
145                 150                 155                 160 


Arg Ile Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu Tyr Arg Ser Thr 
                165                 170                 175     


Asn Pro Arg Ala Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys 
            180                 185                 190         


Arg Arg Phe Gln Leu Tyr Arg Ser Met Asn Ser Arg Ala Arg Lys Asn 
        195                 200                 205             


Arg Ser Gln Ile Val Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys 
    210                 215                 220                 


Ser Met Ser Cys Arg Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Val 
225                 230                 235                 240 


Ser Gly Ala Trp Gly Gly Gly Gly Gly Gly Glu Glu Leu Gly Gly Leu 
                245                 250                 255     


Glu Ala Gly 
            


<210>  4846
<211>  1272
<212>  DNA
<213>  Homosapiens

<400>  4846
gcctgggtga caaagcaaga ttctgtgtca aaacaaaaca aaacaaaaaa ggagggactc     60

agagagccag ggaccaggga aggacatgaa gcagtgttcg gaggacagag agagagaaga    120

atggggaggg gaaggagcgg cacatggggt tgagcagagg agaaaatcag aaagatggct    180

tagagaagcc agcagtctgc aagtctgggg aggatggaga gtggtttggg gttttgggtc    240

ggggtctaag gtgatcagat gcagaagcat tacacggtgg cctggtttct ttactcagcc    300

cctggggtag atcccagccc cccatgtagg tcccttggct ggaaaaggaa gagggagtgg    360

tcagatgaat ctgaggagga gccggagaag gagctcgccc ctgagcctga ggagacctgg    420

gtagtggaga tgctgtgtgg gctcaagatg aagctgaagc aacagcgagt gtcatccatc    480

ctccctgagc accacaagga cttcaacagt cagcttgccc ctggggtaga tcccagcccc    540

ccgcataggt ccttttgctg gaaaaggaag atggagtggt gggacgaatc tgaggagtcg    600

ttggaggagg agccacggaa ggtgctcgcc cctgagcctg aggagatctg ggtggcggag    660

atgctgtgtg gcctcaagat gaagctgaag cgacggcgag tgtcgctcgt gctccctgag    720

caccacgagg ccttcaacag gctgcttgag gatcctgtca ttaaaagatt cttggcctgg    780

gacaaagatc tgagggtgtc ggacaagtat ctcctggcta tggtcatagc gtatttcagc    840

cgggctggct tcccctcctg gcaataccaa cgcattcatt tcttcctggc tctctacctg    900

gccaatgaca tggaggagga cgacgaggac tccaaacaaa acatcttcca cttcctggcc    960

aggaagaacc gctctcgcat acccttgctc cgtaagcgtc ggttccagtt ataccgttcc   1020

acgaacccga gggccaggaa gaaccgctct cgcataccct tgctccgtaa gcgtcggttc   1080

cagttatacc gttccatgaa ctcgagggcc aggaagaacc gctctcagat agtcctgttc   1140

cagaaacgac ggttccactt cttctgttcc atgagctgca gggcttgggt ttccccagag   1200

gagttggagg agatccaggc ttatgaccca gagcactggg tgtgggcgcg agatcgcgct   1260

cacctttcct ag                                                       1272


<210>  4847
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  4847

Met Gln Lys His Tyr Thr Val Ala Trp Phe Leu Tyr Ser Ala Pro Gly 
1               5                   10                  15      


Val Asp Pro Ser Pro Pro Cys Arg Ser Leu Gly Trp Lys Arg Lys Arg 
            20                  25                  30          


Glu Trp Ser Asp Glu Ser Glu Glu Glu Pro Glu Lys Glu Leu Ala Pro 
        35                  40                  45              


Glu Pro Glu Glu Thr Trp Val Val Glu Met Leu Cys Gly Leu Lys Met 
    50                  55                  60                  


Lys Leu Lys Gln Gln Arg Val Ser Ser Ile Leu Pro Glu His His Lys 
65                  70                  75                  80  


Asp Phe Asn Ser Gln Leu Ala Pro Gly Val Asp Pro Ser Pro Pro His 
                85                  90                  95      


Arg Ser Phe Cys Trp Lys Arg Lys Met Glu Trp Trp Asp Glu Ser Glu 
            100                 105                 110         


Glu Ser Leu Glu Glu Glu Pro Arg Lys Val Leu Ala Pro Glu Pro Glu 
        115                 120                 125             


Glu Ile Trp Val Ala Glu Met Leu Cys Gly Leu Lys Met Lys Leu Lys 
    130                 135                 140                 


Arg Arg Arg Val Ser Leu Val Leu Pro Glu His His Glu Ala Phe Asn 
145                 150                 155                 160 


Arg Leu Leu Glu Asp Pro Val Ile Lys Arg Phe Leu Ala Trp Asp Lys 
                165                 170                 175     


Asp Leu Arg Val Ser Asp Lys Tyr Leu Leu Ala Met Val Ile Ala Tyr 
            180                 185                 190         


Phe Ser Arg Ala Gly Phe Pro Ser Trp Gln Tyr Gln Arg Ile His Phe 
        195                 200                 205             


Phe Leu Ala Leu Tyr Leu Ala Asn Asp Met Glu Glu Asp Asp Glu Asp 
    210                 215                 220                 


Ser Lys Gln Asn Ile Phe His Phe Leu Ala Arg Lys Asn Arg Ser Arg 
225                 230                 235                 240 


Ile Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu Tyr Arg Ser Thr Asn 
                245                 250                 255     


Pro Arg Ala Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Arg 
            260                 265                 270         


Arg Phe Gln Leu Tyr Arg Ser Met Asn Ser Arg Ala Arg Lys Asn Arg 
        275                 280                 285             


Ser Gln Ile Val Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys Ser 
    290                 295                 300                 


Met Ser Cys Arg Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Ile Gln 
305                 310                 315                 320 


Ala Tyr Asp Pro Glu His Trp Val Trp Ala Arg Asp Arg Ala His Leu 
                325                 330                 335     


Ser 
    


<210>  4848
<211>  2903
<212>  DNA
<213>  Homosapiens

<400>  4848
ggaccaggga aggatatgag gaagtgttct gaggacagaa aaacgggaga atggggagga     60

gaaggagcgg cacatggagc tcagcagagg agacagacag aaggaaagat ggcttggaga    120

agccagcagt ctgcgaggct ggggaggatg gagagtggtt tggggttttg ggtcgggctc    180

tagtgtgatc aactgcagaa gcattacacc gtggcctggt ttctttactc agcccctggg    240

gtagatccca gccccccgca taggtccttt tgctggaaaa ggaagatgga gtggtgggac    300

gaatctgagg agtcgttgga ggaggagcca cggaaggtgc tcgcccctga gcctgaggag    360

atctgggtgg cggagatgct gtgtggcctc aagatgaagc tgaagcgacg gcgagtgtcg    420

ctcgtgctcc ctgagcacca cgaggccttc aacaggctgc ttgaggatcc tgtcattaaa    480

agattcttgg cctgggacaa agatctgagg gtgtcggaca agtatctcct ggctatggtc    540

atagcgtatt tcagccgggc tggcttcccc tcctggcaat accaacgcat tcatttcttc    600

ctggctctct acctggccaa tgacatggag gaggacgacg aggactccaa acaaaacatc    660

ttccacttcc tgtataggaa gaaccgctct cgcataccct tgctccgtaa gccgtcggtt    720

ccagttatac cgttccatga actcgagggc caggaagaac cgctctcaga tagtcctgtt    780

ccagaaacga cggttccact tcttctgttc catgagctgc agggcttggg tttccccaga    840

ggagttggag gagatccagg cttatgaccc agagcactgg gtgtgggcgc gagatcgcgc    900

tcacctttcc tagagctcca gggaccgggg aggcctgagg tcatcggcct gagagaagaa    960

cactggaccc aggggagatg tggattttca gcaggaactt tattccaatg ctaatggcag   1020

acaccaggca ggaggagagg aaccatttgt gcagatcatc tagaagaacc tggaccattc   1080

ttgatggagc tgaatacagt gatcacgttg tcctcctagg agcaggggtg gggggagggg   1140

ggtggggtcc ttctaggagt ccttggagaa aagtaagaaa ccaggagcgt ttccagttcc   1200

accctttcct gcggcaccac cacccttttt atattgctga attccaacct ccctggggcg   1260

gaacctggag gtcctgtttc ttacggactt gcagtccagg aggatttgaa ggcacaatgc   1320

aggggctcag attgggacag aattcttttg tgaaatatca gtgccacaga ttgtaacaga   1380

tagcttcatg cacactctgc attttattgg tttgtttgga aaatgtcggc cattgaatta   1440

ttcatagatt tatttcaaat agtttggaaa ttgttgtact tttgaaaaca tgctgttcct   1500

gtagtttttt gatgagagtt atagttgtta tatatacata aagataattt tcttttcatt   1560

tttaagagac aattctttta tcctaaatat tttattatct ttaaatttgt ttctgtatta   1620

ttatatgtgc tcctgaagcg agcactcttt ttatctatga tacttccata ataatctctt   1680

ctatttatag ctattggtag ttccccacca gaaaaataca taattctggt gatagaaatt   1740

tttatttgct gtttaggttt gtgactgaat tgtgagaatt cagttgtgat ttttaacatg   1800

tctcagatat atatactaac acgtctaata tatactatct attttattgg tttattttga   1860

aaaacatggg tatagaatta tttaaatatt attttattta tttaaatatt tattaaatat   1920

atttatttat ttaaatatta tttttacatt aaatattatt ttaaatattt tggaaatact   1980

ggtatttttg aatagatgct gtttctacaa agctgtgtga tgggtattat aactgttata   2040

tacacataca tataattttg ttttcctttt taagagagga ttcttttcat cctaaatctt   2100

ttacctttca atctttgtat ctattattac acgtgctgct gaagggagca tggattttat   2160

ctatgatact tagttaacat atatattaca tttatagcta tgtagtagtt cccctaaatt   2220

cttgtaaaaa taaattttta tttgatattt catatatgtt tgaaatgtga gaattcagat   2280

gtaatttttt accttgtttt ggcatgtttg tatattactt taaagagaat gtgtgttcta   2340

aaggaggaca tgagctgtgt gttttcaaga gaacaataga gtgggtctct tggggaaaca   2400

taataaaaat gaacttttct caccttcaca gcaattgtga tcatattggt ctggattgat   2460

tatttgctgc ccagtgatat ttttccttaa tggggttgtg gttatttgaa catatttatt   2520

agctctggaa gataatcctg tgctgttttt tatgtagaaa aaaacataag gctgggtgca   2580

gtgctcacac ctacaatccc tgcggttttg gaggtcatgg tgggaggatc acctgaggcc   2640

aggagtttga ggccagcctc agcaacatag catctacatc tatttttaat ttttattttt   2700

taaagaaaaa caatagaaga gaaggctgat cccaagctac agggtttttt tgtttgtttg   2760

tttgttttgg agacagagtc ttgctctgtc tcccaggctg gagtgcagtg gcacaacctc   2820

ggctccctgc aactttcacc tctgggttca aacaaattct cctgcctcag cctcccaagt   2880

agctgggact acaggcaccc gtc                                           2903


<210>  4849
<211>  193
<212>  PRT
<213>  Homosapiens

<400>  4849

Met Glu Trp Trp Asp Glu Ser Glu Glu Ser Leu Glu Glu Glu Pro Arg 
1               5                   10                  15      


Lys Val Leu Ala Pro Glu Pro Glu Glu Ile Trp Val Ala Glu Met Leu 
            20                  25                  30          


Cys Gly Leu Lys Met Lys Leu Lys Arg Arg Arg Val Ser Leu Val Leu 
        35                  40                  45              


Pro Glu His His Glu Ala Phe Asn Arg Leu Leu Glu Asp Pro Val Ile 
    50                  55                  60                  


Lys Arg Phe Leu Ala Trp Asp Lys Asp Leu Arg Val Ser Asp Lys Tyr 
65                  70                  75                  80  


Leu Leu Ala Met Val Ile Ala Tyr Phe Ser Arg Ala Gly Phe Pro Ser 
                85                  90                  95      


Trp Gln Tyr Gln Arg Ile His Phe Phe Leu Ala Leu Tyr Leu Ala Asn 
            100                 105                 110         


Asp Met Glu Glu Asp Asp Glu Asp Ser Lys Gln Asn Ile Phe His Phe 
        115                 120                 125             


Leu Tyr Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Pro Ser 
    130                 135                 140                 


Val Pro Val Ile Pro Phe His Glu Leu Glu Gly Gln Glu Glu Pro Leu 
145                 150                 155                 160 


Ser Asp Ser Pro Val Pro Glu Thr Thr Val Pro Leu Leu Leu Phe His 
                165                 170                 175     


Glu Leu Gln Gly Leu Gly Phe Pro Arg Gly Val Gly Gly Asp Pro Gly 
            180                 185                 190         


Leu 
    


<210>  4850
<211>  3263
<212>  DNA
<213>  Homosapiens

<400>  4850
gcctgggtga caaagcaaga ttctgtgtca aaacaaaaca aaacaaaaaa ggagggactc     60

agagagccag ggaccaggga aggacatgaa gcagtgttcg gaggacagag agagagaaga    120

atggggaggg gaaggagcgg cacatggggt tgagcagagg agaaaatcag aaagatggct    180

tagagaagcc agcagtctgc aagtctgggg aggatggaga gtggtttggg gttttgggtc    240

ggggtctaag gtgatcagat gcagaagcat tacacggtgg cctggtttct ttactcagcc    300

cctggggtag atcccagccc cccatgtagg tcccttggct ggaaaaggaa gagggagtgg    360

tcagatgaat ctgaggagga gccggagaag gagctcgccc ctgagcctga ggagacctgg    420

gtagtggaga tgctgtgtgg gctcaagatg aagctgaagc aacagcgagt gtcatccatc    480

ctccctgagc accacaagga cttcaacagt cagcttgccc ctggggtaga tcccagcccc    540

ccgcataggt ccttttgctg gaaaaggaag atggagtggt gggacgaatc tgaggagtcg    600

ttggaggagg agccacggaa ggtgctcgcc cctgagcctg aggagatctg ggtggcggag    660

atgctgtgtg gcctcaagat gaagctgaag cgacggcgag tgtcgctcgt gctccctgag    720

caccacgagg ccttcaacag gctgcttgag gatcctgtca ttaaaagatt cttggcctgg    780

gacaaagatc tgagggtgtc ggacaagtat ctcctggcta tggtcatagc gtatttcagc    840

cgggctggct tcccctcctg gcaataccaa cgcattcatt tcttcctggc tctctacctg    900

gccaatgaca tggaggagga cgacgaggac tccaaacaaa acatcttcca cttcctgtat    960

aggaagaacc gctctcgcat acccttgctc cgtaagccgt cggttccagt tataccgttc   1020

cacgaacccg agggccagga agaaccgctc tcgcataccc ttgctccgta agcgtcggtt   1080

ccagttatac cgttccatga actcgagggc caggaagaac cgctctcaga tagtcctgtt   1140

ccagaaacga cggttccact tcttctgttc catgagctgc agggcttggg tttccccaga   1200

ggagttggag gagatccagg cttatgaccc agagcactgg gtgtgggcgc gagatcgcgc   1260

tcacctttcc tagagctcca gggaccgggg aggcctgagg tcatcggcct gagagaagaa   1320

cactggaccc aggggagatg tggattttca gcaggaactt tattccaatg ctaatggcag   1380

acaccaggca ggaggagagg aaccatttgt gcagatcatc tagaagaacc tggaccattc   1440

ttgatggagc tgaatacagt gatcacgttg tcctcctagg agcaggggtg gggggagggg   1500

ggtggggtcc ttctaggagt ccttggagaa aagtaagaaa ccaggagcgt ttccagttcc   1560

accctttcct gcggcaccac cacccttttt atattgctga attccaacct ccctggggcg   1620

gaacctggag gtcctgtttc ttacggactt gcagtccagg aggatttgaa ggcacaatgc   1680

aggggctcag attgggacag aattcttttg tgaaatatca gtgccacaga ttgtaacaga   1740

tagcttcatg cacactctgc attttattgg tttgtttgga aaatgtcggc cattgaatta   1800

ttcatagatt tatttcaaat agtttggaaa ttgttgtact tttgaaaaca tgctgttcct   1860

gtagtttttt gatgagagtt atagttgtta tatatacata aagataattt tcttttcatt   1920

tttaagagac aattctttta tcctaaatat tttattatct ttaaatttgt ttctgtatta   1980

ttatatgtgc tcctgaagcg agcactcttt ttatctatga tacttccata ataatctctt   2040

ctatttatag ctattggtag ttccccacca gaaaaataca taattctggt gatagaaatt   2100

tttatttgct gtttaggttt gtgactgaat tgtgagaatt cagttgtgat ttttaacatg   2160

tctcagatat atatactaac acgtctaata tatactatct attttattgg tttattttga   2220

aaaacatggg tatagaatta tttaaatatt attttattta tttaaatatt tattaaatat   2280

atttatttat ttaaatatta tttttacatt aaatattatt ttaaatattt tggaaatact   2340

ggtatttttg aatagatgct gtttctacaa agctgtgtga tgggtattat aactgttata   2400

tacacataca tataattttg ttttcctttt taagagagga ttcttttcat cctaaatctt   2460

ttacctttca atctttgtat ctattattac acgtgctgct gaagggagca tggattttat   2520

ctatgatact tagttaacat atatattaca tttatagcta tgtagtagtt cccctaaatt   2580

cttgtaaaaa taaattttta tttgatattt catatatgtt tgaaatgtga gaattcagat   2640

gtaatttttt accttgtttt ggcatgtttg tatattactt taaagagaat gtgtgttcta   2700

aaggaggaca tgagctgtgt gttttcaaga gaacaataga gtgggtctct tggggaaaca   2760

taataaaaat gaacttttct caccttcaca gcaattgtga tcatattggt ctggattgat   2820

tatttgctgc ccagtgatat ttttccttaa tggggttgtg gttatttgaa catatttatt   2880

agctctggaa gataatcctg tgctgttttt tatgtagaaa aaaacataag gctgggtgca   2940

gtgctcacac ctacaatccc tgcggttttg gaggtcatgg tgggaggatc acctgaggcc   3000

aggagtttga ggccagcctc agcaacatag catctacatc tatttttaat ttttattttt   3060

taaagaaaaa caatagaaga gaaggctgat cccaagctac agggtttttt tgtttgtttg   3120

tttgttttgg agacagagtc ttgctctgtc tcccaggctg gagtgcagtg gcacaacctc   3180

ggctccctgc aactttcacc tctgggttca aacaaattct cctgcctcag cctcccaagt   3240

agctgggact acaggcaccc gtc                                           3263


<210>  4851
<211>  270
<212>  PRT
<213>  Homosapiens

<400>  4851

Met Gln Lys His Tyr Thr Val Ala Trp Phe Leu Tyr Ser Ala Pro Gly 
1               5                   10                  15      


Val Asp Pro Ser Pro Pro Cys Arg Ser Leu Gly Trp Lys Arg Lys Arg 
            20                  25                  30          


Glu Trp Ser Asp Glu Ser Glu Glu Glu Pro Glu Lys Glu Leu Ala Pro 
        35                  40                  45              


Glu Pro Glu Glu Thr Trp Val Val Glu Met Leu Cys Gly Leu Lys Met 
    50                  55                  60                  


Lys Leu Lys Gln Gln Arg Val Ser Ser Ile Leu Pro Glu His His Lys 
65                  70                  75                  80  


Asp Phe Asn Ser Gln Leu Ala Pro Gly Val Asp Pro Ser Pro Pro His 
                85                  90                  95      


Arg Ser Phe Cys Trp Lys Arg Lys Met Glu Trp Trp Asp Glu Ser Glu 
            100                 105                 110         


Glu Ser Leu Glu Glu Glu Pro Arg Lys Val Leu Ala Pro Glu Pro Glu 
        115                 120                 125             


Glu Ile Trp Val Ala Glu Met Leu Cys Gly Leu Lys Met Lys Leu Lys 
    130                 135                 140                 


Arg Arg Arg Val Ser Leu Val Leu Pro Glu His His Glu Ala Phe Asn 
145                 150                 155                 160 


Arg Leu Leu Glu Asp Pro Val Ile Lys Arg Phe Leu Ala Trp Asp Lys 
                165                 170                 175     


Asp Leu Arg Val Ser Asp Lys Tyr Leu Leu Ala Met Val Ile Ala Tyr 
            180                 185                 190         


Phe Ser Arg Ala Gly Phe Pro Ser Trp Gln Tyr Gln Arg Ile His Phe 
        195                 200                 205             


Phe Leu Ala Leu Tyr Leu Ala Asn Asp Met Glu Glu Asp Asp Glu Asp 
    210                 215                 220                 


Ser Lys Gln Asn Ile Phe His Phe Leu Tyr Arg Lys Asn Arg Ser Arg 
225                 230                 235                 240 


Ile Pro Leu Leu Arg Lys Pro Ser Val Pro Val Ile Pro Phe His Glu 
                245                 250                 255     


Pro Glu Gly Gln Glu Glu Pro Leu Ser His Thr Leu Ala Pro 
            260                 265                 270 


<210>  4852
<211>  2977
<212>  DNA
<213>  Homosapiens

<400>  4852
tttttttttt tttttttgcg atgactctgt ctcaaaataa attaataaat aaataaaaat     60

aaaaatcaaa taaagaaaaa caaaatcaat aaacaaagaa agtggtttca gctgtgccct    120

ctgaaactta atgtctctta ctgacttttc taaacctaag tgtctccatc catagtgggg    180

gataccaagg ccatggtcac accctgatgt gactgtctca tgaggaaatg atgggaattc    240

ctttatgact ctgcagtggt ccctccgtgt ctgctggagg gggtcctggc tgattcccag    300

ctctacatcc tgtagattct cacacccagg gcctccttcg gcctcttctc aggggagtct    360

cagagcagga gcctctctcc cttgcccagt gaaagtcatt ctcccctctc ccatccacct    420

cacccgcggc cacaatcctg agacttcccc ccgggaggca cacttctcct ccctgccctg    480

ctgctcccac ggaaaccctg tcctgcttct cacactgaca tctgctctct aatcacagag    540

gatcctgtca ttaaaagatt cttggcctgg gacaaagatc tgagggtgtc ggacaagtat    600

ctcctggcta tggtcatagc gtatttcagc cgggctggct tcccctcctg gcaataccaa    660

cgcattcatt tcttcctggc tctctacctg gccaatgaca tggaggagga cgacgaggac    720

tccaaacaaa acatcttcca cttcctggcc aggaagaacc gctctcgcat acccttgctc    780

cgtaagcgtc ggttccagtt ataccgttcc atgaactcga gggccaggaa gaaccgctct    840

cagatagtcc tgttccagaa acgacggttc cacttcttct gttccatgag ctgcagggct    900

tgggtttccc cagaggagtt ggaggagatc caggcttatg acccagagca ctgggtgtgg    960

gcgcgagatc gcgctcacct ttcctagagc tccagggacc ggggaggcct gaggtcatcg   1020

gcctgagaga agaacactgg acccagggga gatgtggatt ttcagcagga actttattcc   1080

aatgctaatg gcagacacca ggcaggagga gaggaaccat ttgtgcagat catctagaag   1140

aacctggacc attcttgatg gagctgaata cagtgatcac gttgtcctcc taggagcagg   1200

ggtgggggga ggggggtggg gtccttctag gagtccttgg agaaaagtaa gaaaccagga   1260

gcgtttccag ttccaccctt tcctgcggca ccaccaccct ttttatattg ctgaattcca   1320

acctccctgg ggcggaacct ggaggtcctg tttcttacgg acttgcagtc caggaggatt   1380

tgaaggcaca atgcaggggc tcagattggg acagaattct tttgtgaaat atcagtgcca   1440

cagattgtaa cagatagctt catgcacact ctgcatttta ttggtttgtt tggaaaatgt   1500

cggccattga attattcata gatttatttc aaatagtttg gaaattgttg tacttttgaa   1560

aacatgctgt tcctgtagtt ttttgatgag agttatagtt gttatatata cataaagata   1620

attttctttt catttttaag agacaattct tttatcctaa atattttatt atctttaaat   1680

ttgtttctgt attattatat gtgctcctga agcgagcact ctttttatct atgatacttc   1740

cataataatc tcttctattt atagctattg gtagttcccc accagaaaaa tacataattc   1800

tggtgataga aatttttatt tgctgtttag gtttgtgact gaattgtgag aattcagttg   1860

tgatttttaa catgtctcag atatatatac taacacgtct aatatatact atctatttta   1920

ttggtttatt ttgaaaaaca tgggtataga attatttaaa tattatttta tttatttaaa   1980

tatttattaa atatatttat ttatttaaat attattttta cattaaatat tattttaaat   2040

attttggaaa tactggtatt tttgaataga tgctgtttct acaaagctgt gtgatgggta   2100

ttataactgt tatatacaca tacatataat tttgttttcc tttttaagag aggattcttt   2160

tcatcctaaa tcttttacct ttcaatcttt gtatctatta ttacacgtgc tgctgaaggg   2220

agcatggatt ttatctatga tacttagtta acatatatat tacatttata gctatgtagt   2280

agttccccta aattcttgta aaaataaatt tttatttgat atttcatata tgtttgaaat   2340

gtgagaattc agatgtaatt ttttaccttg ttttggcatg tttgtatatt actttaaaga   2400

gaatgtgtgt tctaaaggag gacatgagct gtgtgttttc aagagaacaa tagagtgggt   2460

ctcttgggga aacataataa aaatgaactt ttctcacctt cacagcaatt gtgatcatat   2520

tggtctggat tgattatttg ctgcccagtg atatttttcc ttaatggggt tgtggttatt   2580

tgaacatatt tattagctct ggaagataat cctgtgctgt tttttatgta gaaaaaaaca   2640

taaggctggg tgcagtgctc acacctacaa tccctgcggt tttggaggtc atggtgggag   2700

gatcacctga ggccaggagt ttgaggccag cctcagcaac atagcatcta catctatttt   2760

taatttttat tttttaaaga aaaacaatag aagagaaggc tgatcccaag ctacagggtt   2820

tttttgtttg tttgtttgtt ttggagacag agtcttgctc tgtctcccag gctggagtgc   2880

agtggcacaa cctcggctcc ctgcaacttt cacctctggg ttcaaacaaa ttctcctgcc   2940

tcagcctccc aagtagctgg gactacaggc acccgtc                            2977


<210>  4853
<211>  125
<212>  PRT
<213>  Homosapiens

<400>  4853

Met Val Ile Ala Tyr Phe Ser Arg Ala Gly Phe Pro Ser Trp Gln Tyr 
1               5                   10                  15      


Gln Arg Ile His Phe Phe Leu Ala Leu Tyr Leu Ala Asn Asp Met Glu 
            20                  25                  30          


Glu Asp Asp Glu Asp Ser Lys Gln Asn Ile Phe His Phe Leu Ala Arg 
        35                  40                  45              


Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu 
    50                  55                  60                  


Tyr Arg Ser Met Asn Ser Arg Ala Arg Lys Asn Arg Ser Gln Ile Val 
65                  70                  75                  80  


Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys Ser Met Ser Cys Arg 
                85                  90                  95      


Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Ile Gln Ala Tyr Asp Pro 
            100                 105                 110         


Glu His Trp Val Trp Ala Arg Asp Arg Ala His Leu Ser 
        115                 120                 125 


<210>  4854
<211>  3052
<212>  DNA
<213>  Homosapiens

<400>  4854
ggaccaggga aggatatgag gaagtgttct gaggacagaa aaacgggaga atggggagga     60

gaaggagcgg cacatggagc tcagcagagg agacagacag aaggaaagat ggcttggaga    120

agccagcagt ctgcgaggct ggggaggatg gagagtggtt tggggttttg ggtcgggctc    180

tagtgtgatc aactgcagaa gcattacacc gtggcctggt ttctttactc agcccctggg    240

gtagatccca gccccccgca taggtccttt tgctggaaaa ggaagatgga gtggtgggac    300

gaatctgagg agtcgttgga ggaggagcca cggaaggtgc tcgcccctga gcctgaggag    360

atctgggtgg cggagatgct gtgtggcctc aagatgaagc tgaagcgacg gcgagtgtcg    420

ctcgtgctcc ctgagcacca cgaggccttc aacaggctgc ttgaggatcc tgtcattaaa    480

agattcttgg cctgggacaa agatctgagg gtgtcggaca agtatctcct ggctatggtc    540

atagcgtatt tcagccgggc tggcttcccc tcctggcaat accaacgcat tcatttcttc    600

ctggctctct acctggccaa tgacatggag gaggacgacg aggactccaa acaaaacatc    660

ttccacttcc tgtataggaa gaaccgctct cgcataccct tgctccgtaa gcgttggttc    720

cagttaggcc attccatgaa cccgagggcc aggaagaacc gctctcgcat acccttgctc    780

cgtaagcgtc ggttccagtt ataccgttcc acgaacccga gggccaggaa gaaccgctct    840

cgcataccct tgctccgtaa gcgtcggttc cagttatacc gttccatgaa ctcgagggcc    900

aggaagaacc gctctcagat agtcctgttc cagaaacgac ggttccactt cttctgttcc    960

atgagctgca gggcttgggt ttccccagag gagttggagg agatccaggc ttatgaccca   1020

gagcactggg tgtgggcgcg agatcgcgct cacctttcct agagctccag ggaccgggga   1080

ggcctgaggt catcggcctg agagaagaac actggaccca ggggagatgt ggattttcag   1140

caggaacttt attccaatgc taatggcaga caccaggcag gaggagagga accatttgtg   1200

cagatcatct agaagaacct ggaccattct tgatggagct gaatacagtg atcacgttgt   1260

cctcctagga gcaggggtgg ggggaggggg gtggggtcct tctaggagtc cttggagaaa   1320

agtaagaaac caggagcgtt tccagttcca ccctttcctg cggcaccacc acccttttta   1380

tattgctgaa ttccaacctc cctggggcgg aacctggagg tcctgtttct tacggacttg   1440

cagtccagga ggatttgaag gcacaatgca ggggctcaga ttgggacaga attcttttgt   1500

gaaatatcag tgccacagat tgtaacagat agcttcatgc acactctgca ttttattggt   1560

ttgtttggaa aatgtcggcc attgaattat tcatagattt atttcaaata gtttggaaat   1620

tgttgtactt ttgaaaacat gctgttcctg tagttttttg atgagagtta tagttgttat   1680

atatacataa agataatttt cttttcattt ttaagagaca attcttttat cctaaatatt   1740

ttattatctt taaatttgtt tctgtattat tatatgtgct cctgaagcga gcactctttt   1800

tatctatgat acttccataa taatctcttc tatttatagc tattggtagt tccccaccag   1860

aaaaatacat aattctggtg atagaaattt ttatttgctg tttaggtttg tgactgaatt   1920

gtgagaattc agttgtgatt tttaacatgt ctcagatata tatactaaca cgtctaatat   1980

atactatcta ttttattggt ttattttgaa aaacatgggt atagaattat ttaaatatta   2040

ttttatttat ttaaatattt attaaatata tttatttatt taaatattat ttttacatta   2100

aatattattt taaatatttt ggaaatactg gtatttttga atagatgctg tttctacaaa   2160

gctgtgtgat gggtattata actgttatat acacatacat ataattttgt tttccttttt   2220

aagagaggat tcttttcatc ctaaatcttt tacctttcaa tctttgtatc tattattaca   2280

cgtgctgctg aagggagcat ggattttatc tatgatactt agttaacata tatattacat   2340

ttatagctat gtagtagttc ccctaaattc ttgtaaaaat aaatttttat ttgatatttc   2400

atatatgttt gaaatgtgag aattcagatg taatttttta ccttgttttg gcatgtttgt   2460

atattacttt aaagagaatg tgtgttctaa aggaggacat gagctgtgtg ttttcaagag   2520

aacaatagag tgggtctctt ggggaaacat aataaaaatg aacttttctc accttcacag   2580

caattgtgat catattggtc tggattgatt atttgctgcc cagtgatatt tttccttaat   2640

ggggttgtgg ttatttgaac atatttatta gctctggaag ataatcctgt gctgtttttt   2700

atgtagaaaa aaacataagg ctgggtgcag tgctcacacc tacaatccct gcggttttgg   2760

aggtcatggt gggaggatca cctgaggcca ggagtttgag gccagcctca gcaacatagc   2820

atctacatct atttttaatt tttatttttt aaagaaaaac aatagaagag aaggctgatc   2880

ccaagctaca gggttttttt gtttgtttgt ttgttttgga gacagagtct tgctctgtct   2940

cccaggctgg agtgcagtgg cacaacctcg gctccctgca actttcacct ctgggttcaa   3000

acaaattctc ctgcctcagc ctcccaagta gctgggacta caggcacccg tc           3052


<210>  4855
<211>  258
<212>  PRT
<213>  Homosapiens

<400>  4855

Met Glu Trp Trp Asp Glu Ser Glu Glu Ser Leu Glu Glu Glu Pro Arg 
1               5                   10                  15      


Lys Val Leu Ala Pro Glu Pro Glu Glu Ile Trp Val Ala Glu Met Leu 
            20                  25                  30          


Cys Gly Leu Lys Met Lys Leu Lys Arg Arg Arg Val Ser Leu Val Leu 
        35                  40                  45              


Pro Glu His His Glu Ala Phe Asn Arg Leu Leu Glu Asp Pro Val Ile 
    50                  55                  60                  


Lys Arg Phe Leu Ala Trp Asp Lys Asp Leu Arg Val Ser Asp Lys Tyr 
65                  70                  75                  80  


Leu Leu Ala Met Val Ile Ala Tyr Phe Ser Arg Ala Gly Phe Pro Ser 
                85                  90                  95      


Trp Gln Tyr Gln Arg Ile His Phe Phe Leu Ala Leu Tyr Leu Ala Asn 
            100                 105                 110         


Asp Met Glu Glu Asp Asp Glu Asp Ser Lys Gln Asn Ile Phe His Phe 
        115                 120                 125             


Leu Tyr Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Arg Trp 
    130                 135                 140                 


Phe Gln Leu Gly His Ser Met Asn Pro Arg Ala Arg Lys Asn Arg Ser 
145                 150                 155                 160 


Arg Ile Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu Tyr Arg Ser Thr 
                165                 170                 175     


Asn Pro Arg Ala Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys 
            180                 185                 190         


Arg Arg Phe Gln Leu Tyr Arg Ser Met Asn Ser Arg Ala Arg Lys Asn 
        195                 200                 205             


Arg Ser Gln Ile Val Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys 
    210                 215                 220                 


Ser Met Ser Cys Arg Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Ile 
225                 230                 235                 240 


Gln Ala Tyr Asp Pro Glu His Trp Val Trp Ala Arg Asp Arg Ala His 
                245                 250                 255     


Leu Ser 
        


<210>  4856
<211>  4063
<212>  DNA
<213>  Homosapiens

<400>  4856
gcctgggtga caaagcaaga ttctgtgtca aaacaaaaca aaacaaaaaa ggagggactc     60

agagagccag ggaccaggga aggacatgaa gcagtgttcg gaggacagag agagagaaga    120

atggggaggg gaaggagcgg cacatggggt tgagcagagg agaaaatcag aaagatggct    180

tagagaagcc agcagtctgc aagtctgggg aggatggaga gtggtttggg gttttgggtc    240

ggggtctaag gtgatcagat gcagaagcat tacacggtgg cctggtttct ttactcagcc    300

cctggggtag atcccagccc cccatgtagg tcccttggct ggaaaaggaa gagggagtgg    360

tcagatgaat ctgaggagga gccggagaag gagctcgccc ctgagcctga ggagacctgg    420

gtagtggaga tgctgtgtgg gctcaagatg aagctgaagc aacagcgagt gtcatccatc    480

ctccctgagc accacaagga cttcaacagt cagcttgagg atcctgtcat taaaagattc    540

ttggcctggg acaaagatct gagggtgtcg gacaagtatc tcctggctat ggtcatagcg    600

tatttcagcc gggctggctt cccctcctgg caataccaac gcattcattt cttcctggct    660

ctctacctgg ccaatgacat ggaggaggac gacgaggact ccaaacaaaa catcttccac    720

ttcctgtata ggaagaaccg ctctcgcata cccttgctcc gtaagcgttg gttccagtta    780

ggccattcca tgaacccgag ggccaggaag aaccgctctc gcataccctt gctccgtaag    840

cgtcggttcc agttataccg ttccacgaac ccgagggcca ggaagaaccg ctctcgcata    900

cccttgctcc gtaagcgtcg gttccagtta taccgttcca tgaactcgag ggccaggaag    960

aaccgctctc agatagtcct gttccagaaa cgacggttcc acttcttctg ttccatgagc   1020

tgcagggctt gggtttcccc agaggagttg gaggaggtga gtggggcctg gggaggtgga   1080

ggaggtgggg aggaattggg tgggctggag gctggatgag gggagagagg ggtatcctgg   1140

cgagtccccg tcttctcaaa gggcgtttgt ttttccagat ccaggcttat gacccagagc   1200

actgggtgtg ggcgcgagat cgcgctcacc tttcctagag ctccagggac cggggaggcc   1260

tgaggtcatc ggcctgagag aaggtacatc tgcatcctct ggggtaaagg cagaatattg   1320

gggtctattt cggaaatccg aagaacccaa ttgcttgatc tggcttcaag cctgggcaac   1380

gtggcgagat cccctctcca caaaaataca aaaattagcc aggcgatgtg ggacgcatct   1440

ctactcccaa ctactcagga ggctgaggcg ggaggatcgc tggagcctgg aaggtcgggg   1500

ccgcacggag ccctgatcct gccactgcac tccagtctgg gcgacagagt gagaccctgc   1560

ctcaaaaata atcataaaaa ctgagtttgg ggaggttcat tatgattgac gcacttgagt   1620

tactgatttg ggtcgagggt tcagtgaagc tttggtttac atcttgtgca gctaaccacg   1680

ttgagcacag agcatgagac ttcatcatga ggaggtagga ttaaggatta ggcttctgga   1740

ctcgtggttc gtgatgttgt cacattagaa acacatctag catggttaca agtttagatc   1800

ttaagtgaca caaaaggccc cagctgtgat aaagtccaaa gccacattct ctgagggtgc   1860

cctactccct gggcagaccc acccaaagtc cttgctatga agcagatcac tggggctgac   1920

cttgggtgta ttaagtgagt tttggagtcg tggtcaccaa agtgtgagtt tcacagttga   1980

acacgatggt tcagaagcag ggtatagaat gaaaggcagc agataaaatt gcatttctca   2040

attgacatgg gacgtgaata actttcctgt ctagagagct gcctccttga agtgtgacat   2100

tgtctctctc gcctccagaa cactggaccc aggggagatg tggattttca gcaggaactt   2160

tattccaatg ctaatggcag acaccaggca ggaggagagg aaccatttgt gcagatcatc   2220

tagaagaacc tggaccattc ttgatggagc tgaatacagt gatcacgttg tcctcctagg   2280

agcaggggtg gggggagggg ggtggggtcc ttctaggagt ccttggagaa aagtaagaaa   2340

ccaggagcgt ttccagttcc accctttcct gcggcaccac cacccttttt atattgctga   2400

attccaacct ccctggggcg gaacctggag gtcctgtttc ttacggactt gcagtccagg   2460

aggatttgaa ggcacaatgc aggggctcag attgggacag aattcttttg tgaaatatca   2520

gtgccacaga ttgtaacaga tagcttcatg cacactctgc attttattgg tttgtttgga   2580

aaatgtcggc cattgaatta ttcatagatt tatttcaaat agtttggaaa ttgttgtact   2640

tttgaaaaca tgctgttcct gtagtttttt gatgagagtt atagttgtta tatatacata   2700

aagataattt tcttttcatt tttaagagac aattctttta tcctaaatat tttattatct   2760

ttaaatttgt ttctgtatta ttatatgtgc tcctgaagcg agcactcttt ttatctatga   2820

tacttccata ataatctctt ctatttatag ctattggtag ttccccacca gaaaaataca   2880

taattctggt gatagaaatt tttatttgct gtttaggttt gtgactgaat tgtgagaatt   2940

cagttgtgat ttttaacatg tctcagatat atatactaac acgtctaata tatactatct   3000

attttattgg tttattttga aaaacatggg tatagaatta tttaaatatt attttattta   3060

tttaaatatt tattaaatat atttatttat ttaaatatta tttttacatt aaatattatt   3120

ttaaatattt tggaaatact ggtatttttg aatagatgct gtttctacaa agctgtgtga   3180

tgggtattat aactgttata tacacataca tataattttg ttttcctttt taagagagga   3240

ttcttttcat cctaaatctt ttacctttca atctttgtat ctattattac acgtgctgct   3300

gaagggagca tggattttat ctatgatact tagttaacat atatattaca tttatagcta   3360

tgtagtagtt cccctaaatt cttgtaaaaa taaattttta tttgatattt catatatgtt   3420

tgaaatgtga gaattcagat gtaatttttt accttgtttt ggcatgtttg tatattactt   3480

taaagagaat gtgtgttcta aaggaggaca tgagctgtgt gttttcaaga gaacaataga   3540

gtgggtctct tggggaaaca taataaaaat gaacttttct caccttcaca gcaattgtga   3600

tcatattggt ctggattgat tatttgctgc ccagtgatat ttttccttaa tggggttgtg   3660

gttatttgaa catatttatt agctctggaa gataatcctg tgctgttttt tatgtagaaa   3720

aaaacataag gctgggtgca gtgctcacac ctacaatccc tgcggttttg gaggtcatgg   3780

tgggaggatc acctgaggcc aggagtttga ggccagcctc agcaacatag catctacatc   3840

tatttttaat ttttattttt taaagaaaaa caatagaaga gaaggctgat cccaagctac   3900

agggtttttt tgtttgtttg tttgttttgg agacagagtc ttgctctgtc tcccaggctg   3960

gagtgcagtg gcacaacctc ggctccctgc aactttcacc tctgggttca aacaaattct   4020

cctgcctcag cctcccaagt agctgggact acaggcaccc gtc                     4063


<210>  4857
<211>  286
<212>  PRT
<213>  Homosapiens

<400>  4857

Met Gln Lys His Tyr Thr Val Ala Trp Phe Leu Tyr Ser Ala Pro Gly 
1               5                   10                  15      


Val Asp Pro Ser Pro Pro Cys Arg Ser Leu Gly Trp Lys Arg Lys Arg 
            20                  25                  30          


Glu Trp Ser Asp Glu Ser Glu Glu Glu Pro Glu Lys Glu Leu Ala Pro 
        35                  40                  45              


Glu Pro Glu Glu Thr Trp Val Val Glu Met Leu Cys Gly Leu Lys Met 
    50                  55                  60                  


Lys Leu Lys Gln Gln Arg Val Ser Ser Ile Leu Pro Glu His His Lys 
65                  70                  75                  80  


Asp Phe Asn Ser Gln Leu Glu Asp Pro Val Ile Lys Arg Phe Leu Ala 
                85                  90                  95      


Trp Asp Lys Asp Leu Arg Val Ser Asp Lys Tyr Leu Leu Ala Met Val 
            100                 105                 110         


Ile Ala Tyr Phe Ser Arg Ala Gly Phe Pro Ser Trp Gln Tyr Gln Arg 
        115                 120                 125             


Ile His Phe Phe Leu Ala Leu Tyr Leu Ala Asn Asp Met Glu Glu Asp 
    130                 135                 140                 


Asp Glu Asp Ser Lys Gln Asn Ile Phe His Phe Leu Tyr Arg Lys Asn 
145                 150                 155                 160 


Arg Ser Arg Ile Pro Leu Leu Arg Lys Arg Trp Phe Gln Leu Gly His 
                165                 170                 175     


Ser Met Asn Pro Arg Ala Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu 
            180                 185                 190         


Arg Lys Arg Arg Phe Gln Leu Tyr Arg Ser Thr Asn Pro Arg Ala Arg 
        195                 200                 205             


Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu 
    210                 215                 220                 


Tyr Arg Ser Met Asn Ser Arg Ala Arg Lys Asn Arg Ser Gln Ile Val 
225                 230                 235                 240 


Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys Ser Met Ser Cys Arg 
                245                 250                 255     


Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Val Ser Gly Ala Trp Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Glu Glu Leu Gly Gly Leu Glu Ala Gly 
        275                 280                 285     


<210>  4858
<211>  348
<212>  DNA
<213>  Homosapiens

<400>  4858
atgaacgccc ctccagcctt cgagtcgttc ttgctcttcg agggcgagaa gatcaccatt     60

aacaaggaca ccaaggtacc caatgcctgt ttattcacca tgaacaaaga agaccacaca    120

ctgggaaaca tcattaaatc acaactccta aaagacccgc aagtgctatt tgctggctac    180

aaagtccccc accccttgga gcacaagatc atcatccgag tgcagaccac gccggactac    240

agcccccagg aagcctttac caacgccatc accgacctca tcagcgagct gtccctgctg    300

gaggagcgct tccggacgtg cctgcttccc cttcgccttc tgccgtga                 348


<210>  4859
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  4859

Met Asn Ala Pro Pro Ala Phe Glu Ser Phe Leu Leu Phe Glu Gly Glu 
1               5                   10                  15      


Lys Ile Thr Ile Asn Lys Asp Thr Lys Val Pro Asn Ala Cys Leu Phe 
            20                  25                  30          


Thr Met Asn Lys Glu Asp His Thr Leu Gly Asn Ile Ile Lys Ser Gln 
        35                  40                  45              


Leu Leu Lys Asp Pro Gln Val Leu Phe Ala Gly Tyr Lys Val Pro His 
    50                  55                  60                  


Pro Leu Glu His Lys Ile Ile Ile Arg Val Gln Thr Thr Pro Asp Tyr 
65                  70                  75                  80  


Ser Pro Gln Glu Ala Phe Thr Asn Ala Ile Thr Asp Leu Ile Ser Glu 
                85                  90                  95      


Leu Ser Leu Leu Glu Glu Arg Phe Arg Thr Cys Leu Leu Pro Leu Arg 
            100                 105                 110         


Leu Leu Pro 
        115 


<210>  4860
<211>  3260
<212>  DNA
<213>  Homosapiens

<400>  4860
gcctgggtga caaagcaaga ttctgtgtca aaacaaaaca aaacaaaaaa ggagggactc     60

agagagccag ggaccaggga aggacaggaa gcagtgttcg gaggacagag agagagaaga    120

atggggaggg gaaggagcgg cacatggggt tgagcagagg agaaaatcag aaagatggct    180

tagagaagcc agcagtctgc aagtctgggg aggatggaga gtggtttggg gttttgggtc    240

ggggtctaag gtgatcagat gcagaagcat tacacggtgg cctggtttct ttactcagcc    300

cctggggtag atcccagccc cccatgtagg tcccttggct ggaaaaggaa gagggagtgg    360

tcagatgaat ctgaggagga gccggagaag gagctcgccc ctgagcctga ggagacctgg    420

gtagtggaga tgctgtgtgg gctcaagatg aagctgaagc aacagcgagt gtcatccatc    480

ctccctgagc accacaagga cttcaacagt cagcttgccc ctggggtaga tcccagcccc    540

ccgcataggt ccttttgctg gaaaaggaag atggagtggt gggacgaatc tgaggagtcg    600

ttggaggagg agccacggaa ggtgctcgcc cctgagcctg aggagatctg ggtggcggag    660

atgctgtgtg gcctcaagat gaagctgaag cgacggcgag tgtcgctcgt gctccctgag    720

caccacgagg ccttcaacag gctgcttgag gatcctgtca ttaaaagatt cttggcctgg    780

gacaaagatc tgagggtgtc ggacaagtat ctcctggcta tggtcatagc gtatttcagc    840

cgggccggct tcccctcctg gcaataccaa cgcattcatt tcttcctggc tctctacctg    900

gccaatgaca tggaggagga cgacgaggac tccaaacaaa acatcttcca cttcctggcc    960

aggaagaacc gctctcgcat acccttgctc cgtaagcgtc ggttccagtt ataccgttcc   1020

acgaacccga gggccaggaa gaaccgctct cgcataccct tgctccgtaa gcgtcggttc   1080

cagttatacc gttccatgaa ctcgagggcc aggaagaacc gctctcagat agtcctgttc   1140

cagaaacgac ggttccactt cttctgttcc atgagctgca gggcttgggt ttccccagag   1200

gagttggagg agatccaggc ttatgaccca gagcactggg tgtgggcgcg agatcgcgct   1260

cacctttcct agagctccag ggaccgggga ggcctgaggt catcggcctg agagaagaac   1320

accggaccca ggggagatgt ggattttcag cgggaacttt attccaatgc taatggcaga   1380

caccaggcag gaggagagga accatttgtg cagatcatct agaagaacct ggaccattct   1440

tgatggagct gaatacagtg atcacgttgt cctcctagga gcaggggtgg ggggaggggg   1500

gtggggtcct tctaggagtc cttggagaaa agtaagaaac caggagcgtt tccagttcca   1560

ccctttcctg cggcaccacc acccttttta tattgctgaa ttccaacctc cctggggcgg   1620

aacctggagg tcctgtttct tacggacttg cagtccagga ggatttgaag gcacaatgca   1680

ggggctcaga ttgggacaga attcttttgt gaaatatcag tgccacagat tgtaacagat   1740

agcttcatgc acactctgca ttttattggt ttgtatggaa aatgtcggcc attgaattat   1800

tcatagattt atttcaaata gtttggaaat tgttgtactt ttgaaaacat gctgttcctg   1860

tagttttttg atgagagtta tagttgttat atatacataa agctaatttt cttttcattt   1920

ttaagagaca attcttttta tcctaaatat tttattatct ttaaatttgt ttctgtatta   1980

ttacatgtgc tcctgaagcg agcactcttt ttatctatga tacttccata ataatctctt   2040

ctatttatag ctattggtag ttccccacca gaaaaaaaca taattctggt gatagaaatt   2100

tttatttgct gtttaggttt gtgactgaat tgtgagaatt cagttgtgat ttttaacatg   2160

cctcagatat atatactaac acgtctaata tatactatct attttattgg tttattttga   2220

aaaacatggg tatagaatta tttaaatatt attttattta tttaaatatt tattaaatat   2280

atttatttat ttaaatatta ttactttaaa tattatttta aatattttgg aaatactggt   2340

atttttgaat agatgctgtt tctataaagc tgtgtgatgg atattataac tgttatatac   2400

acatacatat aattttgttt tcctttttaa gagaggattc ttttcatcct aaatctttta   2460

cctttcaatc tttgtatcta ttattacacg tgctgctgaa gggagcatgg tttttatcta   2520

tgatacttag ttaacatata tattacattt atagctatgt agtagttccc ctaaattctt   2580

gtaaaaataa atttttattt gatatttcat atatatttga aatgtgagaa ttcagatgta   2640

attttttacc ttgttttggc atgtttgtat gttactttaa agaggatgtg tgttctaaag   2700

gaggacatga gctgtgtgtt ttcaagagaa caatagagtg cgtctcttgg ggaaacataa   2760

taaaaatgaa cttttctcac cttcacagca attgtgatca tattggtctg gattgattat   2820

ttgctgccca gtgatatttt tccttaatgg ggttgtggtt atttgaacat atttattagc   2880

tctggaagat aatcctgtgc tgttttttat gtagaaaaaa acataaggct gggtgcagtg   2940

ctcacaccta caatccctgt ggttttggag gtcatggcgg gaggatcacc tgaggccagg   3000

agtttgaggc cagcctcagc aacatagcat ctacatctat ttttaatttt tattttttaa   3060

agaaaaacaa tagaagagaa ggctgatccc aagctacagg gtttttttgt ttgtttgttt   3120

gttttggaga cagagtcttg ctctgtctcc caggctggag tgcagtggca caacctcggc   3180

tccctgcaac tttcacctct gggttcaaac aaattctcct gcctcagcct cccaagtagc   3240

tgggactaca ggcacccgtc                                               3260


<210>  4861
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  4861

Met Gln Lys His Tyr Thr Val Ala Trp Phe Leu Tyr Ser Ala Pro Gly 
1               5                   10                  15      


Val Asp Pro Ser Pro Pro Cys Arg Ser Leu Gly Trp Lys Arg Lys Arg 
            20                  25                  30          


Glu Trp Ser Asp Glu Ser Glu Glu Glu Pro Glu Lys Glu Leu Ala Pro 
        35                  40                  45              


Glu Pro Glu Glu Thr Trp Val Val Glu Met Leu Cys Gly Leu Lys Met 
    50                  55                  60                  


Lys Leu Lys Gln Gln Arg Val Ser Ser Ile Leu Pro Glu His His Lys 
65                  70                  75                  80  


Asp Phe Asn Ser Gln Leu Ala Pro Gly Val Asp Pro Ser Pro Pro His 
                85                  90                  95      


Arg Ser Phe Cys Trp Lys Arg Lys Met Glu Trp Trp Asp Glu Ser Glu 
            100                 105                 110         


Glu Ser Leu Glu Glu Glu Pro Arg Lys Val Leu Ala Pro Glu Pro Glu 
        115                 120                 125             


Glu Ile Trp Val Ala Glu Met Leu Cys Gly Leu Lys Met Lys Leu Lys 
    130                 135                 140                 


Arg Arg Arg Val Ser Leu Val Leu Pro Glu His His Glu Ala Phe Asn 
145                 150                 155                 160 


Arg Leu Leu Glu Asp Pro Val Ile Lys Arg Phe Leu Ala Trp Asp Lys 
                165                 170                 175     


Asp Leu Arg Val Ser Asp Lys Tyr Leu Leu Ala Met Val Ile Ala Tyr 
            180                 185                 190         


Phe Ser Arg Ala Gly Phe Pro Ser Trp Gln Tyr Gln Arg Ile His Phe 
        195                 200                 205             


Phe Leu Ala Leu Tyr Leu Ala Asn Asp Met Glu Glu Asp Asp Glu Asp 
    210                 215                 220                 


Ser Lys Gln Asn Ile Phe His Phe Leu Ala Arg Lys Asn Arg Ser Arg 
225                 230                 235                 240 


Ile Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu Tyr Arg Ser Thr Asn 
                245                 250                 255     


Pro Arg Ala Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Arg 
            260                 265                 270         


Arg Phe Gln Leu Tyr Arg Ser Met Asn Ser Arg Ala Arg Lys Asn Arg 
        275                 280                 285             


Ser Gln Ile Val Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys Ser 
    290                 295                 300                 


Met Ser Cys Arg Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Ile Gln 
305                 310                 315                 320 


Ala Tyr Asp Pro Glu His Trp Val Trp Ala Arg Asp Arg Ala His Leu 
                325                 330                 335     


Ser 
    


<210>  4862
<211>  2900
<212>  DNA
<213>  Homosapiens

<400>  4862
ggaccaggga aggatatgag gaagtgttct gaggacagaa aaacgggaga atggggagga     60

gaaggagcgg cacatggagc tcagcagagg agacagacag aaggaaagat ggcttggaga    120

agccagcagt ctgcgaggct ggggaggatg gagagtggtt tggggttttg ggtcgggctc    180

tagtgtgatc aactgcagaa gcattacacc gtggcctggt ttctttactc agcccctggg    240

gtagatccca gccccccgca taggtccttt tgctggaaaa ggaagatgga gtggtgggac    300

gaatctgagg agtcgttgga ggaggagcca cggaaggtgc tcgcccctga gcctgaggag    360

atctgggtgg cggagatgct gtgtggcctc aagatgaagc tgaagcgacg gcgagtgtcg    420

ctcgtgctcc ctgagcacca cgaggccttc aacaggctgc ttgaggatcc tgtcattaaa    480

agattcttgg cctgggacaa agatctgagg gtgtcggaca agtatctcct ggctatggtc    540

atagcgtatt tcagccgggc cggcttcccc tcctggcaat accaacgcat tcatttcttc    600

ctggctctct acctggccaa tgacatggag gaggacgacg aggactccaa acaaaacatc    660

ttccacttcc tggccaggaa gaaccgctct cgcataccct tgctccgtaa gcgtcggttc    720

cagttatacc gttccatgaa ctcgagggcc aggaagaacc gctctcagat agtcctgttc    780

cagaaacgac ggttccactt cttctgttcc atgagctgca gggcttgggt ttccccagag    840

gagttggagg agatccaggc ttatgaccca gagcactggg tgtgggcgcg agatcgcgct    900

cacctttcct agagctccag ggaccgggga ggcctgaggt catcggcctg agagaagaac    960

accggaccca ggggagatgt ggattttcag cgggaacttt attccaatgc taatggcaga   1020

caccaggcag gaggagagga accatttgtg cagatcatct agaagaacct ggaccattct   1080

tgatggagct gaatacagtg atcacgttgt cctcctagga gcaggggtgg ggggaggggg   1140

gtggggtcct tctaggagtc cttggagaaa agtaagaaac caggagcgtt tccagttcca   1200

ccctttcctg cggcaccacc acccttttta tattgctgaa ttccaacctc cctggggcgg   1260

aacctggagg tcctgtttct tacggacttg cagtccagga ggatttgaag gcacaatgca   1320

ggggctcaga ttgggacaga attcttttgt gaaatatcag tgccacagat tgtaacagat   1380

agcttcatgc acactctgca ttttattggt ttgtatggaa aatgtcggcc attgaattat   1440

tcatagattt atttcaaata gtttggaaat tgttgtactt ttgaaaacat gctgttcctg   1500

tagttttttg atgagagtta tagttgttat atatacataa agctaatttt cttttcattt   1560

ttaagagaca attcttttta tcctaaatat tttattatct ttaaatttgt ttctgtatta   1620

ttacatgtgc tcctgaagcg agcactcttt ttatctatga tacttccata ataatctctt   1680

ctatttatag ctattggtag ttccccacca gaaaaaaaca taattctggt gatagaaatt   1740

tttatttgct gtttaggttt gtgactgaat tgtgagaatt cagttgtgat ttttaacatg   1800

cctcagatat atatactaac acgtctaata tatactatct attttattgg tttattttga   1860

aaaacatggg tatagaatta tttaaatatt attttattta tttaaatatt tattaaatat   1920

atttatttat ttaaatatta ttactttaaa tattatttta aatattttgg aaatactggt   1980

atttttgaat agatgctgtt tctataaagc tgtgtgatgg atattataac tgttatatac   2040

acatacatat aattttgttt tcctttttaa gagaggattc ttttcatcct aaatctttta   2100

cctttcaatc tttgtatcta ttattacacg tgctgctgaa gggagcatgg tttttatcta   2160

tgatacttag ttaacatata tattacattt atagctatgt agtagttccc ctaaattctt   2220

gtaaaaataa atttttattt gatatttcat atatatttga aatgtgagaa ttcagatgta   2280

attttttacc ttgttttggc atgtttgtat gttactttaa agaggatgtg tgttctaaag   2340

gaggacatga gctgtgtgtt ttcaagagaa caatagagtg cgtctcttgg ggaaacataa   2400

taaaaatgaa cttttctcac cttcacagca attgtgatca tattggtctg gattgattat   2460

ttgctgccca gtgatatttt tccttaatgg ggttgtggtt atttgaacat atttattagc   2520

tctggaagat aatcctgtgc tgttttttat gtagaaaaaa acataaggct gggtgcagtg   2580

ctcacaccta caatccctgt ggttttggag gtcatggcgg gaggatcacc tgaggccagg   2640

agtttgaggc cagcctcagc aacatagcat ctacatctat ttttaatttt tattttttaa   2700

agaaaaacaa tagaagagaa ggctgatccc aagctacagg gtttttttgt ttgtttgttt   2760

gttttggaga cagagtcttg ctctgtctcc caggctggag tgcagtggca caacctcggc   2820

tccctgcaac tttcacctct gggttcaaac aaattctcct gcctcagcct cccaagtagc   2880

tgggactaca ggcacccgtc                                               2900


<210>  4863
<211>  208
<212>  PRT
<213>  Homosapiens

<400>  4863

Met Glu Trp Trp Asp Glu Ser Glu Glu Ser Leu Glu Glu Glu Pro Arg 
1               5                   10                  15      


Lys Val Leu Ala Pro Glu Pro Glu Glu Ile Trp Val Ala Glu Met Leu 
            20                  25                  30          


Cys Gly Leu Lys Met Lys Leu Lys Arg Arg Arg Val Ser Leu Val Leu 
        35                  40                  45              


Pro Glu His His Glu Ala Phe Asn Arg Leu Leu Glu Asp Pro Val Ile 
    50                  55                  60                  


Lys Arg Phe Leu Ala Trp Asp Lys Asp Leu Arg Val Ser Asp Lys Tyr 
65                  70                  75                  80  


Leu Leu Ala Met Val Ile Ala Tyr Phe Ser Arg Ala Gly Phe Pro Ser 
                85                  90                  95      


Trp Gln Tyr Gln Arg Ile His Phe Phe Leu Ala Leu Tyr Leu Ala Asn 
            100                 105                 110         


Asp Met Glu Glu Asp Asp Glu Asp Ser Lys Gln Asn Ile Phe His Phe 
        115                 120                 125             


Leu Ala Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Arg Arg 
    130                 135                 140                 


Phe Gln Leu Tyr Arg Ser Met Asn Ser Arg Ala Arg Lys Asn Arg Ser 
145                 150                 155                 160 


Gln Ile Val Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys Ser Met 
                165                 170                 175     


Ser Cys Arg Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Ile Gln Ala 
            180                 185                 190         


Tyr Asp Pro Glu His Trp Val Trp Ala Arg Asp Arg Ala His Leu Ser 
        195                 200                 205             


<210>  4864
<211>  2947
<212>  DNA
<213>  Homosapiens

<400>  4864
gtctcaaaat aaattaataa ataaataaaa ataaaaatcc aataaagaaa aacaaaatca     60

ataaacaaag aaagtggttt cagctgtgcc ctctgaaact taatgtctct tactgacttt    120

tctaaaccta agtgtctcca tccatagtgg gggataccaa ggccatggtc acaccctgat    180

gtgactgtct catgaggaaa tgatgggaat tcctttatga ctctgcagtg gtccctccgt    240

gtctgctgga gggggtcctg gctgattccc agctctacat cctgtagatt ctcacaccca    300

gggcctcctt cggcctcttc tcaggggagt ctcagagcag gagcctctct cccttgccca    360

gtgaaagtca ttctcccctc tcccatccac ctcacccgcg gccacaatcc tgagacttcc    420

ccccgggagg cacacttctc ctcactgccc tgctgctccc acggaaaccc tgtcctgctt    480

ctcacactga catctgctct ctaatcacag aggatcctgt cattaaaaga ttcttggcct    540

gggacaaaga tctgagggtg tcggacaagt atctcctggc tatggtcata gcgtatttca    600

gccgggccgg cttcccctcc tggcaatacc aacgcattca tttcttcctg gctctctacc    660

tggccaatga catggaggag gacgacgagg actccaaaca aaacatcttc cacttcctgg    720

ccaggaagaa ccgctctcgc atacccttgc tccgtaagcg tcggttccag ttataccgtt    780

ccatgaactc gagggccagg aagaaccgct ctcagatagt cctgttccag aaacgacggt    840

tccacttctt ctgttccatg agctgcaggg cttgggtttc cccagaggag ttggaggaga    900

tccaggctta tgacccagag cactgggtgt gggcgcgaga tcgcgctcac ctttcctaga    960

gctccaggga ccggggaggc ctgaggtcat cggcctgaga gaagaacacc ggacccaggg   1020

gagatgtgga ttttcagcgg gaactttatt ccaatgctaa tggcagacac caggcaggag   1080

gagaggaacc atttgtgcag atcatctaga agaacctgga ccattcttga tggagctgaa   1140

tacagtgatc acgttgtcct cctaggagca ggggtggggg gaggggggtg gggtccttct   1200

aggagtcctt ggagaaaagt aagaaaccag gagcgtttcc agttccaccc tttcctgcgg   1260

caccaccacc ctttttatat tgctgaattc caacctccct ggggcggaac ctggaggtcc   1320

tgtttcttac ggacttgcag tccaggagga tttgaaggca caatgcaggg gctcagattg   1380

ggacagaatt cttttgtgaa atatcagtgc cacagattgt aacagatagc ttcatgcaca   1440

ctctgcattt tattggtttg tatggaaaat gtcggccatt gaattattca tagatttatt   1500

tcaaatagtt tggaaattgt tgtacttttg aaaacatgct gttcctgtag ttttttgatg   1560

agagttatag ttgttatata tacataaagc taattttctt ttcattttta agagacaatt   1620

ctttttatcc taaatatttt attatcttta aatttgtttc tgtattatta catgtgctcc   1680

tgaagcgagc actcttttta tctatgatac ttccataata atctcttcta tttatagcta   1740

ttggtagttc cccaccagaa aaaaacataa ttctggtgat agaaattttt atttgctgtt   1800

taggtttgtg actgaattgt gagaattcag ttgtgatttt taacatgcct cagatatata   1860

tactaacacg tctaatatat actatctatt ttattggttt attttgaaaa acatgggtat   1920

agaattattt aaatattatt ttatttattt aaatatttat taaatatatt tatttattta   1980

aatattatta ctttaaatat tattttaaat attttggaaa tactggtatt tttgaataga   2040

tgctgtttct ataaagctgt gtgatggata ttataactgt tatatacaca tacatataat   2100

tttgttttcc tttttaagag aggattcttt tcatcctaaa tcttttacct ttcaatcttt   2160

gtatctatta ttacacgtgc tgctgaaggg agcatggttt ttatctatga tacttagtta   2220

acatatatat tacatttata gctatgtagt agttccccta aattcttgta aaaataaatt   2280

tttatttgat atttcatata tatttgaaat gtgagaattc agatgtaatt ttttaccttg   2340

ttttggcatg tttgtatgtt actttaaaga ggatgtgtgt tctaaaggag gacatgagct   2400

gtgtgttttc aagagaacaa tagagtgcgt ctcttgggga aacataataa aaatgaactt   2460

ttctcacctt cacagcaatt gtgatcatat tggtctggat tgattatttg ctgcccagtg   2520

atatttttcc ttaatggggt tgtggttatt tgaacatatt tattagctct ggaagataat   2580

cctgtgctgt tttttatgta gaaaaaaaca taaggctggg tgcagtgctc acacctacaa   2640

tccctgtggt tttggaggtc atggcgggag gatcacctga ggccaggagt ttgaggccag   2700

cctcagcaac atagcatcta catctatttt taatttttat tttttaaaga aaaacaatag   2760

aagagaaggc tgatcccaag ctacagggtt tttttgtttg tttgtttgtt ttggagacag   2820

agtcttgctc tgtctcccag gctggagtgc agtggcacaa cctcggctcc ctgcaacttt   2880

cacctctggg ttcaaacaaa ttctcctgcc tcagcctccc aagtagctgg gactacaggc   2940

acccgtc                                                             2947


<210>  4865
<211>  125
<212>  PRT
<213>  Homosapiens

<400>  4865

Met Val Ile Ala Tyr Phe Ser Arg Ala Gly Phe Pro Ser Trp Gln Tyr 
1               5                   10                  15      


Gln Arg Ile His Phe Phe Leu Ala Leu Tyr Leu Ala Asn Asp Met Glu 
            20                  25                  30          


Glu Asp Asp Glu Asp Ser Lys Gln Asn Ile Phe His Phe Leu Ala Arg 
        35                  40                  45              


Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu 
    50                  55                  60                  


Tyr Arg Ser Met Asn Ser Arg Ala Arg Lys Asn Arg Ser Gln Ile Val 
65                  70                  75                  80  


Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys Ser Met Ser Cys Arg 
                85                  90                  95      


Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Ile Gln Ala Tyr Asp Pro 
            100                 105                 110         


Glu His Trp Val Trp Ala Arg Asp Arg Ala His Leu Ser 
        115                 120                 125 


<210>  4866
<211>  3050
<212>  DNA
<213>  Homosapiens

<400>  4866
ggaccaggga aggatatgag gaagtgttct gaggacagaa aaacgggaga atggggagga     60

gaaggagcgg cacatggagc tcagcagagg agacagacag aaggaaagat ggcttggaga    120

agccagcagt ctgcgaggct ggggaggatg gagagtggtt tggggttttg ggtcgggctc    180

tagtgtgatc aactgcagaa gcattacacc gtggcctggt ttctttactc agcccctggg    240

gtagatccca gccccccgca taggtccttt tgctggaaaa ggaagatgga gtggtgggac    300

gaatctgagg agtcgttgga ggaggagcca cggaaggtgc tcgcccctga gcctgaggag    360

atctgggtgg cggagatgct gtgtggcctc aagatgaagc tgaagcgacg gcgagtgtcg    420

ctcgtgctcc ctgagcacca cgaggccttc aacaggctgc ttgaggatcc tgtcattaaa    480

agattcttgg cctgggacaa agatctgagg gtgtcggaca agtatctcct ggctatggtc    540

atagcgtatt tcagccgggc cggcttcccc tcctggcaat accaacgcat tcatttcttc    600

ctggctctct acctggccaa tgacatggag gaggacgacg aggactccaa acaaaacatc    660

ttccacttcc tgtataggaa gaaccgctct cgcataccct tgctccgtaa gccttggttc    720

cagttaggcc attccatgaa cccgagggcc aggaagaacc gctctcgcat acccttgctc    780

cgtaagcgtc ggttccagtt ataccgttcc acgaacccga gggccaggaa gaaccgctct    840

cgcataccct tgctccgtaa gcgtcggttc cagttatacc gttccatgaa ctcgagggcc    900

aggaagaacc gctctcagat agtcctgttc cagaaacgac ggttccactt cttctgttcc    960

atgagctgca gggcttgggt ttccccagag gagttggagg agatccaggc ttatgaccca   1020

gagcactggg tgtgggcgcg agatcgcgct cacctttcct agagctccag ggaccgggga   1080

ggcctgaggt catcggcctg agagaagaac accggaccca ggggagatgt ggattttcag   1140

cgggaacttt attccaatgc taatggcaga caccaggcag gaggagagga accatttgtg   1200

cagatcatct agaagaacct ggaccattct tgatggagct gaatacagtg atcacgttgt   1260

cctcctagga gcaggggtgg ggggaggggg gtggggtcct tctaggagtc cttggagaaa   1320

agtaagaaac caggagcgtt tccagttcca ccctttcctg cggcaccacc acccttttta   1380

tattgctgaa ttccaacctc cctggggcgg aacctggagg tcctgtttct tacggacttg   1440

cagtccagga ggatttgaag gcacaatgca ggggctcaga ttgggacaga attcttttgt   1500

gaaatatcag tgccacagat tgtaacagat agcttcatgc acactctgca ttttattggt   1560

ttgtatggaa aatgtcggcc attgaattat tcatagattt atttcaaata gtttggaaat   1620

tgttgtactt ttgaaaacat gctgttcctg tagttttttg atgagagtta tagttgttat   1680

atatacataa agctaatttt cttttcattt ttaagagaca attcttttta tcctaaatat   1740

tttattatct ttaaatttgt ttctgtatta ttacatgtgc tcctgaagcg agcactcttt   1800

ttatctatga tacttccata ataatctctt ctatttatag ctattggtag ttccccacca   1860

gaaaaaaaca taattctggt gatagaaatt tttatttgct gtttaggttt gtgactgaat   1920

tgtgagaatt cagttgtgat ttttaacatg cctcagatat atatactaac acgtctaata   1980

tatactatct attttattgg tttattttga aaaacatggg tatagaatta tttaaatatt   2040

attttattta tttaaatatt tattaaatat atttatttat ttaaatatta ttactttaaa   2100

tattatttta aatattttgg aaatactggt atttttgaat agatgctgtt tctataaagc   2160

tgtgtgatgg atattataac tgttatatac acatacatat aattttgttt tcctttttaa   2220

gagaggattc ttttcatcct aaatctttta cctttcaatc tttgtatcta ttattacacg   2280

tgctgctgaa gggagcatgg tttttatcta tgatacttag ttaacatata tattacattt   2340

atagctatgt agtagttccc ctaaattctt gtaaaaataa atttttattt gatatttcat   2400

atatatttga aatgtgagaa ttcagatgta attttttacc ttgttttggc atgtttgtat   2460

gttactttaa agaggatgtg tgttctaaag gaggacatga gctgtgtgtt ttcaagagaa   2520

caatagagtg cgtctcttgg ggaaacataa taaaaatgaa cttttctcac cttcacagca   2580

attgtgatca tattggtctg gattgattat ttgctgccca gtgatatttt tccttaatgg   2640

ggttgtggtt atttgaacat atttattagc tctggaagat aatcctgtgc tgttttttat   2700

gtagaaaaaa acataaggct gggtgcagtg ctcacaccta caatccctgt ggttttggag   2760

gtcatggcgg gaggatcacc tgaggccagg agtttgaggc cagcctcagc aacatagcat   2820

ctacatctat ttttaatttt tattttttaa agaaaaacaa tagaagagaa ggctgatccc   2880

aagctacagg gtttttttgt ttgtttgttt gttttggaga cagagtcttg ctctgtctcc   2940

caggctggag tgcagtggca caacctcggc tccctgcaac tttcacctct gggttcaaac   3000

aaattctcct gcctcagcct cccaagtagc tgggactaca ggcacccgtc              3050


<210>  4867
<211>  258
<212>  PRT
<213>  Homosapiens

<400>  4867

Met Glu Trp Trp Asp Glu Ser Glu Glu Ser Leu Glu Glu Glu Pro Arg 
1               5                   10                  15      


Lys Val Leu Ala Pro Glu Pro Glu Glu Ile Trp Val Ala Glu Met Leu 
            20                  25                  30          


Cys Gly Leu Lys Met Lys Leu Lys Arg Arg Arg Val Ser Leu Val Leu 
        35                  40                  45              


Pro Glu His His Glu Ala Phe Asn Arg Leu Leu Glu Asp Pro Val Ile 
    50                  55                  60                  


Lys Arg Phe Leu Ala Trp Asp Lys Asp Leu Arg Val Ser Asp Lys Tyr 
65                  70                  75                  80  


Leu Leu Ala Met Val Ile Ala Tyr Phe Ser Arg Ala Gly Phe Pro Ser 
                85                  90                  95      


Trp Gln Tyr Gln Arg Ile His Phe Phe Leu Ala Leu Tyr Leu Ala Asn 
            100                 105                 110         


Asp Met Glu Glu Asp Asp Glu Asp Ser Lys Gln Asn Ile Phe His Phe 
        115                 120                 125             


Leu Tyr Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Pro Trp 
    130                 135                 140                 


Phe Gln Leu Gly His Ser Met Asn Pro Arg Ala Arg Lys Asn Arg Ser 
145                 150                 155                 160 


Arg Ile Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu Tyr Arg Ser Thr 
                165                 170                 175     


Asn Pro Arg Ala Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys 
            180                 185                 190         


Arg Arg Phe Gln Leu Tyr Arg Ser Met Asn Ser Arg Ala Arg Lys Asn 
        195                 200                 205             


Arg Ser Gln Ile Val Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys 
    210                 215                 220                 


Ser Met Ser Cys Arg Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Ile 
225                 230                 235                 240 


Gln Ala Tyr Asp Pro Glu His Trp Val Trp Ala Arg Asp Arg Ala His 
                245                 250                 255     


Leu Ser 
        


<210>  4868
<211>  4061
<212>  DNA
<213>  Homosapiens

<400>  4868
gcctgggtga caaagcaaga ttctgtgtca aaacaaaaca aaacaaaaaa ggagggactc     60

agagagccag ggaccaggga aggacaggaa gcagtgttcg gaggacagag agagagaaga    120

atggggaggg gaaggagcgg cacatggggt tgagcagagg agaaaatcag aaagatggct    180

tagagaagcc agcagtctgc aagtctgggg aggatggaga gtggtttggg gttttgggtc    240

ggggtctaag gtgatcagat gcagaagcat tacacggtgg cctggtttct ttactcagcc    300

cctggggtag atcccagccc cccatgtagg tcccttggct ggaaaaggaa gagggagtgg    360

tcagatgaat ctgaggagga gccggagaag gagctcgccc ctgagcctga ggagacctgg    420

gtagtggaga tgctgtgtgg gctcaagatg aagctgaagc aacagcgagt gtcatccatc    480

ctccctgagc accacaagga cttcaacagt cagcttgagg atcctgtcat taaaagattc    540

ttggcctggg acaaagatct gagggtgtcg gacaagtatc tcctggctat ggtcatagcg    600

tatttcagcc gggccggctt cccctcctgg caataccaac gcattcattt cttcctggct    660

ctctacctgg ccaatgacat ggaggaggac gacgaggact ccaaacaaaa catcttccac    720

ttcctgtata ggaagaaccg ctctcgcata cccttgctcc gtaagccttg gttccagtta    780

ggccattcca tgaacccgag ggccaggaag aaccgctctc gcataccctt gctccgtaag    840

cgtcggttcc agttataccg ttccacgaac ccgagggcca ggaagaaccg ctctcgcata    900

cccttgctcc gtaagcgtcg gttccagtta taccgttcca tgaactcgag ggccaggaag    960

aaccgctctc agatagtcct gttccagaaa cgacggttcc acttcttctg ttccatgagc   1020

tgcagggctt gggtttcccc agaggagttg gaggaggtga gtggggcctg gggaggtgga   1080

ggaggtgggg aggaattggg tgggctggag gctggatgag gggagagagg ggtatcctgg   1140

cgagtccccg tcttctcaaa gggcgtttgt ttttccagat ccaggcttat gacccagagc   1200

actgggtgtg ggcgcgagat cgcgctcacc tttcctagag ctccagggac cggggaggcc   1260

tgaggtcatc ggcctgagag aaggtacatc tgcatcctct ggggtaaagg cagaatattg   1320

gggtctattt cggaaatccg aagaacccaa ttgcttgatc tggcttcaag cctgggcaac   1380

gtggcgagat cccctctcca caaaaataca aaaattagcc aggcgatgtg ggacgcatct   1440

ctactcccaa ctactcagga ggctgaggcg ggaggatcgc tggagcctgg aaggtcgggg   1500

ccgcacggag ccctgatcct gccactgcac tccagtctgg gcgacagagt gagaccctgc   1560

ctcaaaaata atcataaaaa ctgagtttgg ggaggttcat tatgattgac gcacttgagt   1620

tactgatttg ggtcgagggt tcagtgaagc tttggtttac atcttgtgca gctaaccacg   1680

ttgagcacag agcatgagac ttcatcatga ggaggtagga ttaaggatta ggcttctgga   1740

ctcgtggttc gtgatgttgt cacattagaa acacatctag catggttaca agtttagatc   1800

ttaagtgaca caaaaggccc cagctgtgat aaagtccaaa gccacattct ctgagggtgc   1860

cctactccct gggcagaccc acccaaagtc cttgctatga agcagatcac tggggctgac   1920

cttgggtgta ttaagtgagt tttggagtcg tggtcaccaa agtgtgagtt tcacagttga   1980

acacgatggt tcagaagcag ggtatagaat gaaaggcagc agataaaatt gcatttctca   2040

attgacatgg gacgtgaata actttcctgt ctagagagct gcctccttga agtgtgacat   2100

tgtctctctc gcttccagaa caccggaccc aggggagatg tggattttca gcgggaactt   2160

tattccaatg ctaatggcag acaccaggca ggaggagagg aaccatttgt gcagatcatc   2220

tagaagaacc tggaccattc ttgatggagc tgaatacagt gatcacgttg tcctcctagg   2280

agcaggggtg gggggagggg ggtggggtcc ttctaggagt ccttggagaa aagtaagaaa   2340

ccaggagcgt ttccagttcc accctttcct gcggcaccac cacccttttt atattgctga   2400

attccaacct ccctggggcg gaacctggag gtcctgtttc ttacggactt gcagtccagg   2460

aggatttgaa ggcacaatgc aggggctcag attgggacag aattcttttg tgaaatatca   2520

gtgccacaga ttgtaacaga tagcttcatg cacactctgc attttattgg tttgtatgga   2580

aaatgtcggc cattgaatta ttcatagatt tatttcaaat agtttggaaa ttgttgtact   2640

tttgaaaaca tgctgttcct gtagtttttt gatgagagtt atagttgtta tatatacata   2700

aagctaattt tcttttcatt tttaagagac aattcttttt atcctaaata ttttattatc   2760

tttaaatttg tttctgtatt attacatgtg ctcctgaagc gagcactctt tttatctatg   2820

atacttccat aataatctct tctatttata gctattggta gttccccacc agaaaaaaac   2880

ataattctgg tgatagaaat ttttatttgc tgtttaggtt tgtgactgaa ttgtgagaat   2940

tcagttgtga tttttaacat gcctcagata tatatactaa cacgtctaat atatactatc   3000

tattttattg gtttattttg aaaaacatgg gtatagaatt atttaaatat tattttattt   3060

atttaaatat ttattaaata tatttattta tttaaatatt attactttaa atattatttt   3120

aaatattttg gaaatactgg tatttttgaa tagatgctgt ttctataaag ctgtgtgatg   3180

gatattataa ctgttatata cacatacata taattttgtt ttccttttta agagaggatt   3240

cttttcatcc taaatctttt acctttcaat ctttgtatct attattacac gtgctgctga   3300

agggagcatg gtttttatct atgatactta gttaacatat atattacatt tatagctatg   3360

tagtagttcc cctaaattct tgtaaaaata aatttttatt tgatatttca tatatatttg   3420

aaatgtgaga attcagatgt aattttttac cttgttttgg catgtttgta tgttacttta   3480

aagaggatgt gtgttctaaa ggaggacatg agctgtgtgt tttcaagaga acaatagagt   3540

gcgtctcttg gggaaacata ataaaaatga acttttctca ccttcacagc aattgtgatc   3600

atattggtct ggattgatta tttgctgccc agtgatattt ttccttaatg gggttgtggt   3660

tatttgaaca tatttattag ctctggaaga taatcctgtg ctgtttttta tgtagaaaaa   3720

aacataaggc tgggtgcagt gctcacacct acaatccctg tggttttgga ggtcatggcg   3780

ggaggatcac ctgaggccag gagtttgagg ccagcctcag caacatagca tctacatcta   3840

tttttaattt ttatttttta aagaaaaaca atagaagaga aggctgatcc caagctacag   3900

ggtttttttg tttgtttgtt tgttttggag acagagtctt gctctgtctc ccaggctgga   3960

gtgcagtggc acaacctcgg ctccctgcaa ctttcacctc tgggttcaaa caaattctcc   4020

tgcctcagcc tcccaagtag ctgggactac aggcacccgt c                       4061


<210>  4869
<211>  286
<212>  PRT
<213>  Homosapiens

<400>  4869

Met Gln Lys His Tyr Thr Val Ala Trp Phe Leu Tyr Ser Ala Pro Gly 
1               5                   10                  15      


Val Asp Pro Ser Pro Pro Cys Arg Ser Leu Gly Trp Lys Arg Lys Arg 
            20                  25                  30          


Glu Trp Ser Asp Glu Ser Glu Glu Glu Pro Glu Lys Glu Leu Ala Pro 
        35                  40                  45              


Glu Pro Glu Glu Thr Trp Val Val Glu Met Leu Cys Gly Leu Lys Met 
    50                  55                  60                  


Lys Leu Lys Gln Gln Arg Val Ser Ser Ile Leu Pro Glu His His Lys 
65                  70                  75                  80  


Asp Phe Asn Ser Gln Leu Glu Asp Pro Val Ile Lys Arg Phe Leu Ala 
                85                  90                  95      


Trp Asp Lys Asp Leu Arg Val Ser Asp Lys Tyr Leu Leu Ala Met Val 
            100                 105                 110         


Ile Ala Tyr Phe Ser Arg Ala Gly Phe Pro Ser Trp Gln Tyr Gln Arg 
        115                 120                 125             


Ile His Phe Phe Leu Ala Leu Tyr Leu Ala Asn Asp Met Glu Glu Asp 
    130                 135                 140                 


Asp Glu Asp Ser Lys Gln Asn Ile Phe His Phe Leu Tyr Arg Lys Asn 
145                 150                 155                 160 


Arg Ser Arg Ile Pro Leu Leu Arg Lys Pro Trp Phe Gln Leu Gly His 
                165                 170                 175     


Ser Met Asn Pro Arg Ala Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu 
            180                 185                 190         


Arg Lys Arg Arg Phe Gln Leu Tyr Arg Ser Thr Asn Pro Arg Ala Arg 
        195                 200                 205             


Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu 
    210                 215                 220                 


Tyr Arg Ser Met Asn Ser Arg Ala Arg Lys Asn Arg Ser Gln Ile Val 
225                 230                 235                 240 


Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys Ser Met Ser Cys Arg 
                245                 250                 255     


Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Val Ser Gly Ala Trp Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Glu Glu Leu Gly Gly Leu Glu Ala Gly 
        275                 280                 285     


<210>  4870
<211>  4007
<212>  DNA
<213>  Homosapiens

<400>  4870
ggaccaggga aggatatgag gaagtgttct gaggacagaa aaacgggaga atggggagga     60

gaaggagcgg cacatggagc tcagcagagg agacagacag aaggaaagat ggcttggaga    120

agccagcagt ctgcgaggct ggggaggatg gagagtggtt tggggttttg ggtcgggctc    180

tagtgtgatc aactgcagaa gcattacacc gtggcctggt ttctttactc agcccctggg    240

gtagatccca gccccccgca taggtccttt tgctggaaaa ggaagatgga gtggtgggac    300

gaatctgagg agtcgttgga ggaggagcca cggaaggtgc tcgcccctga gcctgaggag    360

atctgggtgg cggagatgct gtgtggcctc aagatgaagc tgaagcgacg gcgagtgtcg    420

ctcgtgctcc ctgagcacca cgaggccttc aacaggctgc ttgaggatcc tgtcattaaa    480

agattcttgg cctgggacaa agatctgagg gtgtcggaca agtatctcct ggctatggtc    540

atagcgtatt tcagccgggc cggcttcccc tcctggcaat accaacgcat tcatttcttc    600

ctggctctct acctggccaa tgacatggag gaggacgacg aggactccaa acaaaacatc    660

ttccacttcc tgtataggaa gaaccgctct cgcataccct tgctccgtaa gccttggttc    720

cagttaggcc attccatgaa cccgagggcc aggaagaacc gctctcgcat acccttgctc    780

cgtaagcgtc ggttccagtt ataccgttcc acgaacccga gggccaggaa gaaccgctct    840

cgcataccct tgctccgtaa gcgtcggttc cagttatacc gttccatgaa ctcgagggcc    900

aggaagaacc gctctcagat agtcctgttc cagaaacgac ggttccactt cttctgttcc    960

atgagctgca gggcttgggt ttccccagag gagttggagg aggtgagtgg ggcctgggga   1020

ggtggaggag gtggggagga attgggtggg ctggaggctg gatgagggga gagaggggta   1080

tcctggcgag tccccgtctt ctcaaagggc gtttgttttt ccagatccag gcttatgacc   1140

cagagcactg ggtgtgggcg cgagatcgcg ctcacctttc ctagagctcc agggaccggg   1200

gaggcctgag gtcatcggcc tgagagaagg tacatctgca tcctctgggg taaaggcaga   1260

atattggggt ctatttcgga aatccgaaga acccaattgc ttgatctggc ttcaagcctg   1320

ggcaacgtgg cgagatcccc tctccacaaa aatacaaaaa ttagccaggc gatgtgggac   1380

gcatctctac tcccaactac tcaggaggct gaggcgggag gatcgctgga gcctggaagg   1440

tcggggccgc acggagccct gatcctgcca ctgcactcca gtctgggcga cagagtgaga   1500

ccctgcctca aaaataatca taaaaactga gtttggggag gttcattatg attgacgcac   1560

ttgagttact gatttgggtc gagggttcag tgaagctttg gtttacatct tgtgcagcta   1620

accacgttga gcacagagca tgagacttca tcatgaggag gtaggattaa ggattaggct   1680

tctggactcg tggttcgtga tgttgtcaca ttagaaacac atctagcatg gttacaagtt   1740

tagatcttaa gtgacacaaa aggccccagc tgtgataaag tccaaagcca cattctctga   1800

gggtgcccta ctccctgggc agacccaccc aaagtccttg ctatgaagca gatcactggg   1860

gctgaccttg ggtgtattaa gtgagttttg gagtcgtggt caccaaagtg tgagtttcac   1920

agttgaacac gatggttcag aagcagggta tagaatgaaa ggcagcagat aaaattgcat   1980

ttctcaattg acatgggacg tgaataactt tcctgtctag agagctgcct ccttgaagtg   2040

tgacattgtc tctctcgctt ccagaacacc ggacccaggg gagatgtgga ttttcagcgg   2100

gaactttatt ccaatgctaa tggcagacac caggcaggag gagaggaacc atttgtgcag   2160

atcatctaga agaacctgga ccattcttga tggagctgaa tacagtgatc acgttgtcct   2220

cctaggagca ggggtggggg gaggggggtg gggtccttct aggagtcctt ggagaaaagt   2280

aagaaaccag gagcgtttcc agttccaccc tttcctgcgg caccaccacc ctttttatat   2340

tgctgaattc caacctccct ggggcggaac ctggaggtcc tgtttcttac ggacttgcag   2400

tccaggagga tttgaaggca caatgcaggg gctcagattg ggacagaatt cttttgtgaa   2460

atatcagtgc cacagattgt aacagatagc ttcatgcaca ctctgcattt tattggtttg   2520

tatggaaaat gtcggccatt gaattattca tagatttatt tcaaatagtt tggaaattgt   2580

tgtacttttg aaaacatgct gttcctgtag ttttttgatg agagttatag ttgttatata   2640

tacataaagc taattttctt ttcattttta agagacaatt ctttttatcc taaatatttt   2700

attatcttta aatttgtttc tgtattatta catgtgctcc tgaagcgagc actcttttta   2760

tctatgatac ttccataata atctcttcta tttatagcta ttggtagttc cccaccagaa   2820

aaaaacataa ttctggtgat agaaattttt atttgctgtt taggtttgtg actgaattgt   2880

gagaattcag ttgtgatttt taacatgcct cagatatata tactaacacg tctaatatat   2940

actatctatt ttattggttt attttgaaaa acatgggtat agaattattt aaatattatt   3000

ttatttattt aaatatttat taaatatatt tatttattta aatattatta ctttaaatat   3060

tattttaaat attttggaaa tactggtatt tttgaataga tgctgtttct ataaagctgt   3120

gtgatggata ttataactgt tatatacaca tacatataat tttgttttcc tttttaagag   3180

aggattcttt tcatcctaaa tcttttacct ttcaatcttt gtatctatta ttacacgtgc   3240

tgctgaaggg agcatggttt ttatctatga tacttagtta acatatatat tacatttata   3300

gctatgtagt agttccccta aattcttgta aaaataaatt tttatttgat atttcatata   3360

tatttgaaat gtgagaattc agatgtaatt ttttaccttg ttttggcatg tttgtatgtt   3420

actttaaaga ggatgtgtgt tctaaaggag gacatgagct gtgtgttttc aagagaacaa   3480

tagagtgcgt ctcttgggga aacataataa aaatgaactt ttctcacctt cacagcaatt   3540

gtgatcatat tggtctggat tgattatttg ctgcccagtg atatttttcc ttaatggggt   3600

tgtggttatt tgaacatatt tattagctct ggaagataat cctgtgctgt tttttatgta   3660

gaaaaaaaca taaggctggg tgcagtgctc acacctacaa tccctgtggt tttggaggtc   3720

atggcgggag gatcacctga ggccaggagt ttgaggccag cctcagcaac atagcatcta   3780

catctatttt taatttttat tttttaaaga aaaacaatag aagagaaggc tgatcccaag   3840

ctacagggtt tttttgtttg tttgtttgtt ttggagacag agtcttgctc tgtctcccag   3900

gctggagtgc agtggcacaa cctcggctcc ctgcaacttt cacctctggg ttcaaacaaa   3960

ttctcctgcc tcagcctccc aagtagctgg gactacaggc acccgtc                 4007


<210>  4871
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  4871

Met Glu Trp Trp Asp Glu Ser Glu Glu Ser Leu Glu Glu Glu Pro Arg 
1               5                   10                  15      


Lys Val Leu Ala Pro Glu Pro Glu Glu Ile Trp Val Ala Glu Met Leu 
            20                  25                  30          


Cys Gly Leu Lys Met Lys Leu Lys Arg Arg Arg Val Ser Leu Val Leu 
        35                  40                  45              


Pro Glu His His Glu Ala Phe Asn Arg Leu Leu Glu Asp Pro Val Ile 
    50                  55                  60                  


Lys Arg Phe Leu Ala Trp Asp Lys Asp Leu Arg Val Ser Asp Lys Tyr 
65                  70                  75                  80  


Leu Leu Ala Met Val Ile Ala Tyr Phe Ser Arg Ala Gly Phe Pro Ser 
                85                  90                  95      


Trp Gln Tyr Gln Arg Ile His Phe Phe Leu Ala Leu Tyr Leu Ala Asn 
            100                 105                 110         


Asp Met Glu Glu Asp Asp Glu Asp Ser Lys Gln Asn Ile Phe His Phe 
        115                 120                 125             


Leu Tyr Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys Pro Trp 
    130                 135                 140                 


Phe Gln Leu Gly His Ser Met Asn Pro Arg Ala Arg Lys Asn Arg Ser 
145                 150                 155                 160 


Arg Ile Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu Tyr Arg Ser Thr 
                165                 170                 175     


Asn Pro Arg Ala Arg Lys Asn Arg Ser Arg Ile Pro Leu Leu Arg Lys 
            180                 185                 190         


Arg Arg Phe Gln Leu Tyr Arg Ser Met Asn Ser Arg Ala Arg Lys Asn 
        195                 200                 205             


Arg Ser Gln Ile Val Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys 
    210                 215                 220                 


Ser Met Ser Cys Arg Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Val 
225                 230                 235                 240 


Ser Gly Ala Trp Gly Gly Gly Gly Gly Gly Glu Glu Leu Gly Gly Leu 
                245                 250                 255     


Glu Ala Gly 
            


<210>  4872
<211>  438
<212>  DNA
<213>  Homosapiens

<400>  4872
gagctctccg gtccgtgcct ccaagatgac aaagaaaaga aggaacaatg gtcgtgccaa     60

aaagggccgc ggccacgtgc aacctgttcg ctgtactaac tgtgcccgat gcgtgcccaa    120

ggacaaggcc attaagaaat tcgtcattcg aaacatagtg gaggccgtag cagtcaggga    180

catttctgaa gcaagcgtct tcgatgccta tgtgcttccc aagctgtatg tgaagctaca    240

ttactgtgtg agttgtgcaa ttcacagcaa agtagtcagg aatcgatctc gtgaagcccg    300

caaggaccga acacccccac ccagatttag acctgcgggt gctgccccac gtcccccacc    360

aaagcccatg taaggagctg agttcttaaa gactgaagac aggttattct ctggagaaaa    420

ataaaatgga aattgttc                                                  438


<210>  4873
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  4873

Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly 
1               5                   10                  15      


His Val Gln Pro Val Arg Cys Thr Asn Cys Ala Arg Cys Val Pro Lys 
            20                  25                  30          


Asp Lys Ala Ile Lys Lys Phe Val Ile Arg Asn Ile Val Glu Ala Val 
        35                  40                  45              


Ala Val Arg Asp Ile Ser Glu Ala Ser Val Phe Asp Ala Tyr Val Leu 
    50                  55                  60                  


Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Val Ser Cys Ala Ile His 
65                  70                  75                  80  


Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Arg Lys Asp Arg Thr 
                85                  90                  95      


Pro Pro Pro Arg Phe Arg Pro Ala Gly Ala Ala Pro Arg Pro Pro Pro 
            100                 105                 110         


Lys Pro Met 
        115 


<210>  4874
<211>  472
<212>  DNA
<213>  Homosapiens

<400>  4874
aagagctctc cggtccgtgc ctccaagatg acaaagaaaa gaaggaacaa tggtcgtgcc     60

aaaaagggcc gcggccacgt gcaacctgtt cgctgtacta actgtgcccg atgcgtgccc    120

aaggacaagg ccattaagaa attcgtcatt cgaaacatag tggaggccgt agcagtcagg    180

gacatttctg aagcaagcgt cttcgatgcc tatgtgcttc ccaagctgta tgtgaagcta    240

cattactgtg tgagttgtgc aattcacagc aaagtagtca ggaatcgatc tcgtgaagcc    300

cgcaaggacc gaacaccccc acccagattt agacctgcgg gtgctgcccc acgtccccca    360

ccaaagccca tgtaaggagc tgagttctta aagactgaag acaggttatt ctctggagaa    420

aaataaaatg gaaattgtaa aaaaataata ataataataa aagaaagaaa aa            472


<210>  4875
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  4875

Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly 
1               5                   10                  15      


His Val Gln Pro Val Arg Cys Thr Asn Cys Ala Arg Cys Val Pro Lys 
            20                  25                  30          


Asp Lys Ala Ile Lys Lys Phe Val Ile Arg Asn Ile Val Glu Ala Val 
        35                  40                  45              


Ala Val Arg Asp Ile Ser Glu Ala Ser Val Phe Asp Ala Tyr Val Leu 
    50                  55                  60                  


Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Val Ser Cys Ala Ile His 
65                  70                  75                  80  


Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Arg Lys Asp Arg Thr 
                85                  90                  95      


Pro Pro Pro Arg Phe Arg Pro Ala Gly Ala Ala Pro Arg Pro Pro Pro 
            100                 105                 110         


Lys Pro Met 
        115 


<210>  4876
<211>  438
<212>  DNA
<213>  Homosapiens

<400>  4876
gagctctccg gtccgtgcct ccaagatgac aaagaaaaga aggaacaatg gtcgtgccaa     60

aaagggccgc ggccacgtgc aacctgttcg ctgtactaac tgtgcccgat gcgtgcccaa    120

ggacaaggcc attaagaaat tcgtcattcg aaacatagtg gaggccgtag cagtcaggga    180

catttctgaa gcaagcgtct tcgatgccta tgtgcttccc aagctgtatg tgaagctaca    240

ttactgtgtg agttgtgcaa ttcacagcaa agtagtcagg aatcgatctc gtgaagcccg    300

caaggaccga acacccccac ccagatttag acctgcgggt gctgccccac gtcccccacc    360

aaagcccatg taaggagctg agttcttaaa gactgaagac aggttattct ctggagaaaa    420

ataaaatgga aattgttc                                                  438


<210>  4877
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  4877

Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly 
1               5                   10                  15      


His Val Gln Pro Val Arg Cys Thr Asn Cys Ala Arg Cys Val Pro Lys 
            20                  25                  30          


Asp Lys Ala Ile Lys Lys Phe Val Ile Arg Asn Ile Val Glu Ala Val 
        35                  40                  45              


Ala Val Arg Asp Ile Ser Glu Ala Ser Val Phe Asp Ala Tyr Val Leu 
    50                  55                  60                  


Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Val Ser Cys Ala Ile His 
65                  70                  75                  80  


Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Arg Lys Asp Arg Thr 
                85                  90                  95      


Pro Pro Pro Arg Phe Arg Pro Ala Gly Ala Ala Pro Arg Pro Pro Pro 
            100                 105                 110         


Lys Pro Met 
        115 


<210>  4878
<211>  472
<212>  DNA
<213>  Homosapiens

<400>  4878
aagagctctc cggtccgtgc ctccaagatg acaaagaaaa gaaggaacaa tggtcgtgcc     60

aaaaagggcc gcggccacgt gcaacctgtt cgctgtacta actgtgcccg atgcgtgccc    120

aaggacaagg ccattaagaa attcgtcatt cgaaacatag tggaggccgt agcagtcagg    180

gacatttctg aagcaagcgt cttcgatgcc tatgtgcttc ccaagctgta tgtgaagcta    240

cattactgtg tgagttgtgc aattcacagc aaagtagtca ggaatcgatc tcgtgaagcc    300

cgcaaggacc gaacaccccc acccagattt agacctgcgg gtgctgcccc acgtccccca    360

ccaaagccca tgtaaggagc tgagttctta aagactgaag acaggttatt ctctggagaa    420

aaataaaatg gaaattgtaa aaaaataata ataataataa aagaaagaaa aa            472


<210>  4879
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  4879

Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly 
1               5                   10                  15      


His Val Gln Pro Val Arg Cys Thr Asn Cys Ala Arg Cys Val Pro Lys 
            20                  25                  30          


Asp Lys Ala Ile Lys Lys Phe Val Ile Arg Asn Ile Val Glu Ala Val 
        35                  40                  45              


Ala Val Arg Asp Ile Ser Glu Ala Ser Val Phe Asp Ala Tyr Val Leu 
    50                  55                  60                  


Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Val Ser Cys Ala Ile His 
65                  70                  75                  80  


Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Arg Lys Asp Arg Thr 
                85                  90                  95      


Pro Pro Pro Arg Phe Arg Pro Ala Gly Ala Ala Pro Arg Pro Pro Pro 
            100                 105                 110         


Lys Pro Met 
        115 


<210>  4880
<211>  1040
<212>  DNA
<213>  Homosapiens

<400>  4880
atgcgcacat ttgctcagaa tgagaaaaaa atggaagagg tggtgccagg gccgttgcta     60

ggatacgacc aacagctgag aacgcggcga gtatggaagc tgcgtcttag gagcctggga    120

aagcacttcg acgagaatag tttggtttcc actattttta atagtaaaaa actagagggg    180

tctgcatggc ggggcctcgg agccaagacg aggttgagta gactcgtttt gaattttctc    240

ccctctgctc cggcggactt cccatgtcgc cttgtggggc tatcggcggc ggcaggactg    300

ggggagtcag aggtctggca gcgctgtctg cgcagaccta ccggacgcta cctcccaacc    360

cccctttctt cctcctgcct cctcctcctc ccgtcacctc ctgacccgcc ggagctccga    420

gcaactgccg gcctccgccc ccagccgcag ccggtcactg gcggcgcctt ccgcgccaag    480

cttgggggcc ttttcggggt cctacatggc acggcttccg acccccggcc cgggacgggg    540

ctcgcaggcc ccagaggggc aggctggaga aggaggaggt taggtgtctt caggagggtt    600

gctgagccca aggacgcgcc atcgccgcgg agaaggagcc ggaccccttg ggcggagcgc    660

ccaatgtgtg gtccctcacg ccgtcccgca ccttgctttt tagggttctt tttccgcttt    720

ctgagccctt ttatacctta cgtttagaag gggaaaatca tcctcccaca ccttctcccc    780

gactttttgc cttttttgtc ttgaagttac ccaaaggtct gtgtattgtt ctcagtggtc    840

ccaagaatta ctcgaatata gttgtttttc tgagggagga tggatggaga taactatcct    900

gatcccagtg tcacttttta aggcattcgc ttcaagagac aagcagttta gaatcaggca    960

gaactggatt gcaaaattta tgggcagacc ggtatgtgtg aaggaaaatg tctaatcaac   1020

aggagaagta tgaagctcag                                               1040


<210>  4881
<211>  248
<212>  PRT
<213>  Homosapiens

<400>  4881

Met Arg Thr Phe Ala Gln Asn Glu Lys Lys Met Glu Glu Val Val Pro 
1               5                   10                  15      


Gly Pro Leu Leu Gly Tyr Asp Gln Gln Leu Arg Thr Arg Arg Val Trp 
            20                  25                  30          


Lys Leu Arg Leu Arg Ser Leu Gly Lys His Phe Asp Glu Asn Ser Leu 
        35                  40                  45              


Val Ser Thr Ile Phe Asn Ser Lys Lys Leu Glu Gly Ser Ala Trp Arg 
    50                  55                  60                  


Gly Leu Gly Ala Lys Thr Arg Leu Ser Arg Leu Val Leu Asn Phe Leu 
65                  70                  75                  80  


Pro Ser Ala Pro Ala Asp Phe Pro Cys Arg Leu Val Gly Leu Ser Ala 
                85                  90                  95      


Ala Ala Gly Leu Gly Glu Ser Glu Val Trp Gln Arg Cys Leu Arg Arg 
            100                 105                 110         


Pro Thr Gly Arg Tyr Leu Pro Thr Pro Leu Ser Ser Ser Cys Leu Leu 
        115                 120                 125             


Leu Leu Pro Ser Pro Pro Asp Pro Pro Glu Leu Arg Ala Thr Ala Gly 
    130                 135                 140                 


Leu Arg Pro Gln Pro Gln Pro Val Thr Gly Gly Ala Phe Arg Ala Lys 
145                 150                 155                 160 


Leu Gly Gly Leu Phe Gly Val Leu His Gly Thr Ala Ser Asp Pro Arg 
                165                 170                 175     


Pro Gly Thr Gly Leu Ala Gly Pro Arg Gly Ala Gly Trp Arg Arg Arg 
            180                 185                 190         


Arg Leu Gly Val Phe Arg Arg Val Ala Glu Pro Lys Asp Ala Pro Ser 
        195                 200                 205             


Pro Arg Arg Arg Ser Arg Thr Pro Trp Ala Glu Arg Pro Met Cys Gly 
    210                 215                 220                 


Pro Ser Arg Arg Pro Ala Pro Cys Phe Leu Gly Phe Phe Phe Arg Phe 
225                 230                 235                 240 


Leu Ser Pro Phe Ile Pro Tyr Val 
                245             


<210>  4882
<211>  1040
<212>  DNA
<213>  Homosapiens

<400>  4882
atgcgcacat ttgctcagaa tgagaaaaaa atggaagagg tggtgccagg gccgttgcta     60

ggatacgacc aacagctgag aacgcggcga gtatggaagc tgcgtcttag gagcctggga    120

aagcacttcg acgagaatag tttggtttcc actattttta atagtaaaaa actagagggg    180

tctgcatggc ggggcctcgg agccaagacg aggttgagta gactcgtttt gaattttctc    240

ccctctgctc cggcggactt cccatgtcgc cttgtggggc tatcggcggc ggcaggactg    300

ggggagtcag aggtctggca gcgctgtctg cgcagaccta ccggacgcta cctcccaacc    360

cccctttctt cctcctgcct cctcctcctc ccgtcacctc ctgacccgcc ggagctccga    420

gcaactgccg gcctccgccc ccagccgcag ccggtcactg gcggcgcctt ccgcgccaag    480

cttgggggcc ttttcggggt cctacatggc acggcttccg acccccggcc cgggacgggg    540

ctcgcaggcc ccagaggggc aggctggaga aggaggaggt taggtgtctt caggagggtt    600

gctgagccca aggacgcgcc atcgccgcgg agaaggagcc ggaccccttg ggcggagcgc    660

ccaatgtgtg gtccctcacg ccgtcccgca ccttgctttt tagggttctt tttccgcttt    720

ctgagccctt ttatacctta cgtttagaag gggaaaatca tcctcccaca ccttctcccc    780

gactttttgc cttttttgtc ttgaagttac ccaaaggtct gtgtattgtt ctcagtggtc    840

ccaagaatta ctcgaatata gttgtttttc tgagggagga tggatggaga taactatcct    900

gatcccagtg tcacttttta aggcattcgc ttcaagagac aagcagttta gaatcaggca    960

gaactggatt gcaaaattta tgggcagacc ggtatgtgtg aaggaaaatg tctaatcaac   1020

aggagaagta tgaagctcag                                               1040


<210>  4883
<211>  248
<212>  PRT
<213>  Homosapiens

<400>  4883

Met Arg Thr Phe Ala Gln Asn Glu Lys Lys Met Glu Glu Val Val Pro 
1               5                   10                  15      


Gly Pro Leu Leu Gly Tyr Asp Gln Gln Leu Arg Thr Arg Arg Val Trp 
            20                  25                  30          


Lys Leu Arg Leu Arg Ser Leu Gly Lys His Phe Asp Glu Asn Ser Leu 
        35                  40                  45              


Val Ser Thr Ile Phe Asn Ser Lys Lys Leu Glu Gly Ser Ala Trp Arg 
    50                  55                  60                  


Gly Leu Gly Ala Lys Thr Arg Leu Ser Arg Leu Val Leu Asn Phe Leu 
65                  70                  75                  80  


Pro Ser Ala Pro Ala Asp Phe Pro Cys Arg Leu Val Gly Leu Ser Ala 
                85                  90                  95      


Ala Ala Gly Leu Gly Glu Ser Glu Val Trp Gln Arg Cys Leu Arg Arg 
            100                 105                 110         


Pro Thr Gly Arg Tyr Leu Pro Thr Pro Leu Ser Ser Ser Cys Leu Leu 
        115                 120                 125             


Leu Leu Pro Ser Pro Pro Asp Pro Pro Glu Leu Arg Ala Thr Ala Gly 
    130                 135                 140                 


Leu Arg Pro Gln Pro Gln Pro Val Thr Gly Gly Ala Phe Arg Ala Lys 
145                 150                 155                 160 


Leu Gly Gly Leu Phe Gly Val Leu His Gly Thr Ala Ser Asp Pro Arg 
                165                 170                 175     


Pro Gly Thr Gly Leu Ala Gly Pro Arg Gly Ala Gly Trp Arg Arg Arg 
            180                 185                 190         


Arg Leu Gly Val Phe Arg Arg Val Ala Glu Pro Lys Asp Ala Pro Ser 
        195                 200                 205             


Pro Arg Arg Arg Ser Arg Thr Pro Trp Ala Glu Arg Pro Met Cys Gly 
    210                 215                 220                 


Pro Ser Arg Arg Pro Ala Pro Cys Phe Leu Gly Phe Phe Phe Arg Phe 
225                 230                 235                 240 


Leu Ser Pro Phe Ile Pro Tyr Val 
                245             


<210>  4884
<211>  240
<212>  DNA
<213>  Homosapiens

<400>  4884
atggtacacc tgtataggga acttacaata aatggagctt gcaggactgg aagttgcctg     60

ggcgagttag tgaaatgtga gggcagggat gcagctgaaa agctggcggc ccagacagaa    120

gtctgcccca agcagcctga gccctcaggc accccccagc tccctgggag ctcccctcca    180

cctgccaacg tcagtgccac actcgtgtct gaaaggaata acaggaacag gacagactaa    240


<210>  4885
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  4885

Met Val His Leu Tyr Arg Glu Leu Thr Ile Asn Gly Ala Cys Arg Thr 
1               5                   10                  15      


Gly Ser Cys Leu Gly Glu Leu Val Lys Cys Glu Gly Arg Asp Ala Ala 
            20                  25                  30          


Glu Lys Leu Ala Ala Gln Thr Glu Val Cys Pro Lys Gln Pro Glu Pro 
        35                  40                  45              


Ser Gly Thr Pro Gln Leu Pro Gly Ser Ser Pro Pro Pro Ala Asn Val 
    50                  55                  60                  


Ser Ala Thr Leu Val Ser Glu Arg Asn Asn Arg Asn Arg Thr Asp 
65                  70                  75                  


<210>  4886
<211>  5330
<212>  DNA
<213>  Homosapiens

<400>  4886
atgccatcca ctgttctaac agctttatat agaactgtac ctctaataaa gaatgcatgt     60

gtcttttgca gttgtgaaga tgacctctcc gacgacagag aagagcttct gcatgggatt    120

tcagagctgg acatcagcaa ctcggattgt ttcccatccc agctgctagt gcatggggct    180

ttagcctttc ctctagggtt agattcctac catggctgtg ttatagcggc tgcccgctat    240

ggccggggcc gggtggttgt gactggccat aaggtattat tcactgttgg taaactgggc    300

ccctttctgc tcaatgctgt ccgctggctg gatgggggcc gcagaggcaa gattgtggtg    360

cagacagagc tgagaaccct gagtggcctc ctcgcagtgg ggggcataga caccagcatc    420

gagcccaatc tgaccagtga tgcaagtgtc tactgctttg aacccgtgag tgaagtgggg    480

gtcaaggaac tgcaggagtt tgtagcagag ggtggcgggc tatttgttgg agcccaagcc    540

tggtggtggg ccttcaagaa ccccggagtg tcccctttgg ctcgattccc aggaaacctc    600

ctcctcaacc cctttggcat cagcattaca agccaaagcc tcaatccagg gccctttcgt    660

actcctaaag cagggataag gacctatcac ttccgctcca ccttggccga gttccaggtt    720

ataatgggca ggaagagagg aaatgtggaa aagggctggt tggcaaagct gggaccagat    780

ggtgcagctt tcctgcagat tcccgcagaa gagatccctg cctacatgtc tgtgcatcga    840

ctcctgagga agctgctaag tcgatatcgg cttccagtag caacccgaga gaaccctgtt    900

atcaatgact gctgcagagg tgctatgctt tccctggcca cagggctggc ccactctgga    960

agcgacctct ctctgttagt cccagaaatt gaagatatgt acagcagccc ctatctgcgc   1020

ccctcagaat ctcctatcac cgtcgaggtc aactgcacca atccaggcac cagatattgc   1080

tggatgagta ctgggctcta catacctgga aggcaaatta tagaagtctc actgcctgaa   1140

gctgctgcct ctgccgacct gaagatacag attggctgcc acacagatga cctgaccagg   1200

gccagcaagc ttttccgagg cccactcgta attaaccggt gctgcttgga caaacccaca   1260

aaatcgatca cgtgcctctg gggtggactc ctctatataa ttgtgcctca gaacagcaaa   1320

ctgggttctg tgcctgtcac cgtgaagggg gctgtgcatg ctccatacta caagctgggg   1380

gagaccaccc tggaggagtg gaagaggcgt atccaggaga atccagggcc ctggggagag   1440

ctggccacgg acaacatcat tctgaccgtg ccgaccgcaa atcttcgtac tctggagaac   1500

cctgagccgc tgctccgcct ctgggatgag gtgatgcagg ctgtggcgcg actgggagct   1560

gagcccttcc ctttgcgcct gcctcagagg attgttgccg acgtgcagat ctcagtgggc   1620

tggatgcatg cagggtaccc catcatgtgc catctggagt cagtgcagga gctcatcaac   1680

gagaagctca tcagaaccaa ggggctgtgg ggccccgtcc atgagctggg ccgcaaccag   1740

cagcggcagg agtgggagtt cccaccacac accaccgagg ccacctgcaa cctgtggtgt   1800

gtgtatgtgc atgagacggt cttgggcatt cctcgaagcc gtgccaatat tgctctgtgg   1860

cccccagttc gggagaagag agtcagaatc tacctgagca agggtcccaa tgtgaaaaac   1920

tggaatgcat ggaccgcact ggaaacgtat ttacagctcc aggaagcctt tggttgggag   1980

ccattcatcc gtctcttcac cgagtacagg aaccagacca acttgcccac agaaaatgtt   2040

gacaaaatga atctgtgggt caagatgttc tcccaccaag tgcagaagaa cctggctccg   2100

ttctttgagg cctgggcctg gcccatccag aaggaagtgg ctaccagcct ggcctatctg   2160

cctgaatgga aggaaaatat tatgaaattg tacctcctca cacagatgcc ccactgaaat   2220

tgaagtcaag aaatgcaaaa aggaactgac acatctcagc aaagaaaact gaagggattt   2280

ggttataagt ggagaggatc tcagcatatt tctggaagat agaaagtgga tgaagcatga   2340

taatgaaaga gtgaagaacc tttcagataa aatgtaagct gatctgaaca acataacccc   2400

aaagagactt gcgcacctga aaagcttgtc tactgaagaa ttactccagt tgtaagattg   2460

agccctctcc tactctcccc caactcttat gcacagaaca caggcagtct ccactattga   2520

taccagttaa aaatttcttg ttattgttgc tgttgttgtt tgtataaagg aattgaacag   2580

gctgcttgca gagagataag agttggtgct ccagaaaaaa atttctcttc tagtggaaat   2640

aagtgcccct acccccagcc ggtcagctaa ttctctactg acagctgaga cctcctactc   2700

aagtgcctgt tgccttcagg tatagaagag gtttcctgaa gaaacagacc taactgtaca   2760

acagcagagg aaacccatgc caactgttat acaagttaac agttatgttg attcttaaat   2820

gggaatggtg agttagaaat tcccagacat gggcgatggg gagggaagag gaataagaaa   2880

agtcacgagg tagaattagg ggccttgaaa atatgacaaa ctctgaggga aacaaagaca   2940

atgtggaaag aataacttaa ttttaattcc atctccagag agatttgagg tgtatttaag   3000

atgaaaaaca ggatactaca aagaaacgga aaactcagga gttcgagacc agcctaggca   3060

agatggcaac atcccgtctc tacaaaataa tttttaaaaa ttagccaagc atggtggcat   3120

gtgcctgtgg tcctagctac ttgggaggct gaagtgggaa gatcacttga gcccaggagt   3180

tcaaggcttc agtgggccat gatggtgcca ctgcactcca gcctggggga cagagtgaga   3240

ccctgtctct taaaaagcaa gaaaagaaag agaagactga gaataagaag atctctttga   3300

aaataaaata agactgctaa aagtatttgg tatacagtct ggaaaataaa gttgagggaa   3360

tctctccaga taaagagcaa aaagaaatag atagaaaaat ataaagaaag aaaaaagaca   3420

tagacaatca atatgtaatg ttaggagttc ctggaagaga gaacagagac agtgtaggtg   3480

aagaaataaa aagaaaaaga attgaagaac agagcaagct aagtctccag attgagaggg   3540

cccaatacaa tctacatcta gacacaatat tgtaaaattt tggaatatta aggatagaag   3600

gaagatatta aagtggccag ggagaaaaca aatgaggtca tcacgattag ctcaacacaa   3660

aaatggatga gaaatagact gctaacagat ttgtcatcag caacactgaa tgccagaagt   3720

caatggatca acatcttcag agcttatgga aaatttttgt acctagaatt tcatagtaag   3780

gcagactgtc aagaagaaca tcaaagtgaa gacattttct gtcaggcaaa ttttcagaaa   3840

gtctccctcc tttgcaccct tactgaggaa gtatcttgag gaaattctcc agcaaaatga   3900

ggatgaaaac caggaaagaa gaagaaatgg gatccataaa acagtggacc ttacttagga   3960

tgtctcattc tagagtgaca gccaaaaggg tatctcaccc tagagtgaca gctatccagc   4020

agactaattt cagatgagag catactgtct cgggctttct gggaagaatg tgcattcagt   4080

gccatagata gtatcattga agagctggga tgcttgagaa gattatttag tcaagaaaaa   4140

agaaagacaa atcaacaata tgtcaaaaaa ttcaggtcca attatagagc aaaataaaat   4200

gaggcatgat tttgagttat tcatgaagaa taagaagagg cttcataggt acatttcctt   4260

ttctatggca caggcatgat gatattgggt gtgtagggaa gaaaatatcc tagcttatac   4320

taggctccca gtaagaagta tttaaatagc caaaataatg tggatatcat ttattagtat   4380

tcagtgttca gatcagccta ttaacaaagt gtgaaaggtt tcatttttta ttcagaactg   4440

aagttgaaag taattaatgc tgacaaaggg aaagaaagca gaaagagatt gagaattaga   4500

ggaagagaag tggaatcaaa ggtagagata cttatatatt caaagtgggg atgaaaagat   4560

cttcagttaa tggaacaaga actagaggat tagtgtattg ttcaaagcta taaaatcaaa   4620

ccaatagatg tattaaaaag tgatgtaact atcagacatt tggagagaga tggacaaagg   4680

aaagtggcga tagtgtaagt taaatcctta tcttttgtaa tggggaatta ttaaagatgt   4740

tgtaaagtca gtaagtcaag aaattattgc tcaaacatat tatttaaagt tagaaagtta   4800

gttaccagac gatctaaaat aaatattgtt aaaagcatta cctctaggga atgggattta   4860

gatttaaaaa gggtgggatg ggaaactgtg tttttcattt taagtccttc tgtactattt   4920

aattttttac cttgtgcatg tattactttg aaaaaatttt taataaaccc aaataaaaat   4980

cttccagtga cttcccattg attaagatgc aacccagcta aagcctttaa aatggttttc   5040

aaggtcctca agtatctagg tccacttgat gtgtccaggc tcatgatatc tccccacaag   5100

tctctatttc cagccagatt aagtatcttc cagttattaa aacacacttc acattctttt   5160

gtttgtatag gtgttccaca aaaaacaaag cctactgctg atctcaccat gtctgctgag   5220

taagcttacc atctagtggg ttttaatatt tgttgaatga aggaatgtcc aatacagcat   5280

tgaatgaagt ttgccaactt cattcttttc caagaaggcc tttgatgttt              5330


<210>  4887
<211>  738
<212>  PRT
<213>  Homosapiens

<400>  4887

Met Pro Ser Thr Val Leu Thr Ala Leu Tyr Arg Thr Val Pro Leu Ile 
1               5                   10                  15      


Lys Asn Ala Cys Val Phe Cys Ser Cys Glu Asp Asp Leu Ser Asp Asp 
            20                  25                  30          


Arg Glu Glu Leu Leu His Gly Ile Ser Glu Leu Asp Ile Ser Asn Ser 
        35                  40                  45              


Asp Cys Phe Pro Ser Gln Leu Leu Val His Gly Ala Leu Ala Phe Pro 
    50                  55                  60                  


Leu Gly Leu Asp Ser Tyr His Gly Cys Val Ile Ala Ala Ala Arg Tyr 
65                  70                  75                  80  


Gly Arg Gly Arg Val Val Val Thr Gly His Lys Val Leu Phe Thr Val 
                85                  90                  95      


Gly Lys Leu Gly Pro Phe Leu Leu Asn Ala Val Arg Trp Leu Asp Gly 
            100                 105                 110         


Gly Arg Arg Gly Lys Ile Val Val Gln Thr Glu Leu Arg Thr Leu Ser 
        115                 120                 125             


Gly Leu Leu Ala Val Gly Gly Ile Asp Thr Ser Ile Glu Pro Asn Leu 
    130                 135                 140                 


Thr Ser Asp Ala Ser Val Tyr Cys Phe Glu Pro Val Ser Glu Val Gly 
145                 150                 155                 160 


Val Lys Glu Leu Gln Glu Phe Val Ala Glu Gly Gly Gly Leu Phe Val 
                165                 170                 175     


Gly Ala Gln Ala Trp Trp Trp Ala Phe Lys Asn Pro Gly Val Ser Pro 
            180                 185                 190         


Leu Ala Arg Phe Pro Gly Asn Leu Leu Leu Asn Pro Phe Gly Ile Ser 
        195                 200                 205             


Ile Thr Ser Gln Ser Leu Asn Pro Gly Pro Phe Arg Thr Pro Lys Ala 
    210                 215                 220                 


Gly Ile Arg Thr Tyr His Phe Arg Ser Thr Leu Ala Glu Phe Gln Val 
225                 230                 235                 240 


Ile Met Gly Arg Lys Arg Gly Asn Val Glu Lys Gly Trp Leu Ala Lys 
                245                 250                 255     


Leu Gly Pro Asp Gly Ala Ala Phe Leu Gln Ile Pro Ala Glu Glu Ile 
            260                 265                 270         


Pro Ala Tyr Met Ser Val His Arg Leu Leu Arg Lys Leu Leu Ser Arg 
        275                 280                 285             


Tyr Arg Leu Pro Val Ala Thr Arg Glu Asn Pro Val Ile Asn Asp Cys 
    290                 295                 300                 


Cys Arg Gly Ala Met Leu Ser Leu Ala Thr Gly Leu Ala His Ser Gly 
305                 310                 315                 320 


Ser Asp Leu Ser Leu Leu Val Pro Glu Ile Glu Asp Met Tyr Ser Ser 
                325                 330                 335     


Pro Tyr Leu Arg Pro Ser Glu Ser Pro Ile Thr Val Glu Val Asn Cys 
            340                 345                 350         


Thr Asn Pro Gly Thr Arg Tyr Cys Trp Met Ser Thr Gly Leu Tyr Ile 
        355                 360                 365             


Pro Gly Arg Gln Ile Ile Glu Val Ser Leu Pro Glu Ala Ala Ala Ser 
    370                 375                 380                 


Ala Asp Leu Lys Ile Gln Ile Gly Cys His Thr Asp Asp Leu Thr Arg 
385                 390                 395                 400 


Ala Ser Lys Leu Phe Arg Gly Pro Leu Val Ile Asn Arg Cys Cys Leu 
                405                 410                 415     


Asp Lys Pro Thr Lys Ser Ile Thr Cys Leu Trp Gly Gly Leu Leu Tyr 
            420                 425                 430         


Ile Ile Val Pro Gln Asn Ser Lys Leu Gly Ser Val Pro Val Thr Val 
        435                 440                 445             


Lys Gly Ala Val His Ala Pro Tyr Tyr Lys Leu Gly Glu Thr Thr Leu 
    450                 455                 460                 


Glu Glu Trp Lys Arg Arg Ile Gln Glu Asn Pro Gly Pro Trp Gly Glu 
465                 470                 475                 480 


Leu Ala Thr Asp Asn Ile Ile Leu Thr Val Pro Thr Ala Asn Leu Arg 
                485                 490                 495     


Thr Leu Glu Asn Pro Glu Pro Leu Leu Arg Leu Trp Asp Glu Val Met 
            500                 505                 510         


Gln Ala Val Ala Arg Leu Gly Ala Glu Pro Phe Pro Leu Arg Leu Pro 
        515                 520                 525             


Gln Arg Ile Val Ala Asp Val Gln Ile Ser Val Gly Trp Met His Ala 
    530                 535                 540                 


Gly Tyr Pro Ile Met Cys His Leu Glu Ser Val Gln Glu Leu Ile Asn 
545                 550                 555                 560 


Glu Lys Leu Ile Arg Thr Lys Gly Leu Trp Gly Pro Val His Glu Leu 
                565                 570                 575     


Gly Arg Asn Gln Gln Arg Gln Glu Trp Glu Phe Pro Pro His Thr Thr 
            580                 585                 590         


Glu Ala Thr Cys Asn Leu Trp Cys Val Tyr Val His Glu Thr Val Leu 
        595                 600                 605             


Gly Ile Pro Arg Ser Arg Ala Asn Ile Ala Leu Trp Pro Pro Val Arg 
    610                 615                 620                 


Glu Lys Arg Val Arg Ile Tyr Leu Ser Lys Gly Pro Asn Val Lys Asn 
625                 630                 635                 640 


Trp Asn Ala Trp Thr Ala Leu Glu Thr Tyr Leu Gln Leu Gln Glu Ala 
                645                 650                 655     


Phe Gly Trp Glu Pro Phe Ile Arg Leu Phe Thr Glu Tyr Arg Asn Gln 
            660                 665                 670         


Thr Asn Leu Pro Thr Glu Asn Val Asp Lys Met Asn Leu Trp Val Lys 
        675                 680                 685             


Met Phe Ser His Gln Val Gln Lys Asn Leu Ala Pro Phe Phe Glu Ala 
    690                 695                 700                 


Trp Ala Trp Pro Ile Gln Lys Glu Val Ala Thr Ser Leu Ala Tyr Leu 
705                 710                 715                 720 


Pro Glu Trp Lys Glu Asn Ile Met Lys Leu Tyr Leu Leu Thr Gln Met 
                725                 730                 735     


Pro His 
        


<210>  4888
<211>  5330
<212>  DNA
<213>  Homosapiens

<400>  4888
atgccatcca ctgttctaac agctttatat agaactgtac ctctaataaa gaatgcatgt     60

gtcttttgca gttgtgaaga tgacctctcc gacgacagag aagagcttct gcatgggatt    120

tcagagctgg acatcagcaa ctcggattgt ttcccatccc agctgctagt gcatggggct    180

ttagcctttc ctctagggtt agattcctac catggctgtg ttatagcggc tgcccgctat    240

ggccggggcc gggtggttgt gactggccat aaggtattat tcactgttgg taaactgggc    300

ccctttctgc tcaatgctgt ccgctggctg gatgggggcc gcagaggcaa gattgtggtg    360

cagacagagc tgagaaccct gagtggcctc ctcgcagtgg ggggcataga caccagcatc    420

gagcccaatc tgaccagtga tgcaagtgtc tactgctttg aacccgtgag tgaagtgggg    480

gtcaaggaac tgcaggagtt tgtagcagag ggtggcgggc tatttgttgg agcccaagcc    540

tggtggtggg ccttcaagaa ccccggagtg tcccctttgg ctcgattccc aggaaacctc    600

ctcctcaacc cctttggcat cagcattaca agccaaagcc tcaatccagg gccctttcgt    660

actcctaaag cagggataag gacctatcac ttccgctcca ccttggccga gttccaggtt    720

ataatgggca ggaagagagg aaatgtggaa aagggctggt tggcaaagct gggaccagat    780

ggtgcagctt tcctgcagat tcccgcagaa gagatccctg cctacatgtc tgtgcatcga    840

ctcctgagga agctgctaag tcgatatcgg cttccagtag caacccgaga gaaccctgtt    900

atcaatgact gctgcagagg tgctatgctt tccctggcca cagggctggc ccactctgga    960

agcgacctct ctctgttagt cccagaaatt gaagatatgt acagcagccc ctatctgcgc   1020

ccctcagaat ctcctatcac cgtcgaggtc aactgcacca atccaggcac cagatattgc   1080

tggatgagta ctgggctcta catacctgga aggcaaatta tagaagtctc actgcctgaa   1140

gctgctgcct ctgccgacct gaagatacag attggctgcc acacagatga cctgaccagg   1200

gccagcaagc ttttccgagg cccactcgta attaaccggt gctgcttgga caaacccaca   1260

aaatcgatca cgtgcctctg gggtggactc ctctatataa ttgtgcctca gaacagcaaa   1320

ctgggttctg tgcctgtcac cgtgaagggg gctgtgcatg ctccatacta caagctgggg   1380

gagaccaccc tggaggagtg gaagaggcgt atccaggaga atccagggcc ctggggagag   1440

ctggccacgg acaacatcat tctgaccgtg ccgaccgcaa atcttcgtac tctggagaac   1500

cctgagccgc tgctccgcct ctgggatgag gtgatgcagg ctgtggcgcg actgggagct   1560

gagcccttcc ctttgcgcct gcctcagagg attgttgccg acgtgcagat ctcagtgggc   1620

tggatgcatg cagggtaccc catcatgtgc catctggagt cagtgcagga gctcatcaac   1680

gagaagctca tcagaaccaa ggggctgtgg ggccccgtcc atgagctggg ccgcaaccag   1740

cagcggcagg agtgggagtt cccaccacac accaccgagg ccacctgcaa cctgtggtgt   1800

gtgtatgtgc atgagacggt cttgggcatt cctcgaagcc gtgccaatat tgctctgtgg   1860

cccccagttc gggagaagag agtcagaatc tacctgagca agggtcccaa tgtgaaaaac   1920

tggaatgcat ggaccgcact ggaaacgtat ttacagctcc aggaagcctt tggttgggag   1980

ccattcatcc gtctcttcac cgagtacagg aaccagacca acttgcccac agaaaatgtt   2040

gacaaaatga atctgtgggt caagatgttc tcccaccaag tgcagaagaa cctggctccg   2100

ttctttgagg cctgggcctg gcccatccag aaggaagtgg ctaccagcct ggcctatctg   2160

cctgaatgga aggaaaatat tatgaaattg tacctcctca cacagatgcc ccactgaaat   2220

tgaagtcaag aaatgcaaaa aggaactgac acatctcagc aaagaaaact gaagggattt   2280

ggttataagt ggagaggatc tcagcatatt tctggaagat agaaagtgga tgaagcatga   2340

taatgaaaga gtgaagaacc tttcagataa aatgtaagct gatctgaaca acataacccc   2400

aaagagactt gcgcacctga aaagcttgtc tactgaagaa ttactccagt tgtaagattg   2460

agccctctcc tactctcccc caactcttat gcacagaaca caggcagtct ccactattga   2520

taccagttaa aaatttcttg ttattgttgc tgttgttgtt tgtataaagg aattgaacag   2580

gctgcttgca gagagataag agttggtgct ccagaaaaaa atttctcttc tagtggaaat   2640

aagtgcccct acccccagcc ggtcagctaa ttctctactg acagctgaga cctcctactc   2700

aagtgcctgt tgccttcagg tatagaagag gtttcctgaa gaaacagacc taactgtaca   2760

acagcagagg aaacccatgc caactgttat acaagttaac agttatgttg attcttaaat   2820

gggaatggtg agttagaaat tcccagacat gggcgatggg gagggaagag gaataagaaa   2880

agtcacgagg tagaattagg ggccttgaaa atatgacaaa ctctgaggga aacaaagaca   2940

atgtggaaag aataacttaa ttttaattcc atctccagag agatttgagg tgtatttaag   3000

atgaaaaaca ggatactaca aagaaacgga aaactcagga gttcgagacc agcctaggca   3060

agatggcaac atcccgtctc tacaaaataa tttttaaaaa ttagccaagc atggtggcat   3120

gtgcctgtgg tcctagctac ttgggaggct gaagtgggaa gatcacttga gcccaggagt   3180

tcaaggcttc agtgggccat gatggtgcca ctgcactcca gcctggggga cagagtgaga   3240

ccctgtctct taaaaagcaa gaaaagaaag agaagactga gaataagaag atctctttga   3300

aaataaaata agactgctaa aagtatttgg tatacagtct ggaaaataaa gttgagggaa   3360

tctctccaga taaagagcaa aaagaaatag atagaaaaat ataaagaaag aaaaaagaca   3420

tagacaatca atatgtaatg ttaggagttc ctggaagaga gaacagagac agtgtaggtg   3480

aagaaataaa aagaaaaaga attgaagaac agagcaagct aagtctccag attgagaggg   3540

cccaatacaa tctacatcta gacacaatat tgtaaaattt tggaatatta aggatagaag   3600

gaagatatta aagtggccag ggagaaaaca aatgaggtca tcacgattag ctcaacacaa   3660

aaatggatga gaaatagact gctaacagat ttgtcatcag caacactgaa tgccagaagt   3720

caatggatca acatcttcag agcttatgga aaatttttgt acctagaatt tcatagtaag   3780

gcagactgtc aagaagaaca tcaaagtgaa gacattttct gtcaggcaaa ttttcagaaa   3840

gtctccctcc tttgcaccct tactgaggaa gtatcttgag gaaattctcc agcaaaatga   3900

ggatgaaaac caggaaagaa gaagaaatgg gatccataaa acagtggacc ttacttagga   3960

tgtctcattc tagagtgaca gccaaaaggg tatctcaccc tagagtgaca gctatccagc   4020

agactaattt cagatgagag catactgtct cgggctttct gggaagaatg tgcattcagt   4080

gccatagata gtatcattga agagctggga tgcttgagaa gattatttag tcaagaaaaa   4140

agaaagacaa atcaacaata tgtcaaaaaa ttcaggtcca attatagagc aaaataaaat   4200

gaggcatgat tttgagttat tcatgaagaa taagaagagg cttcataggt acatttcctt   4260

ttctatggca caggcatgat gatattgggt gtgtagggaa gaaaatatcc tagcttatac   4320

taggctccca gtaagaagta tttaaatagc caaaataatg tggatatcat ttattagtat   4380

tcagtgttca gatcagccta ttaacaaagt gtgaaaggtt tcatttttta ttcagaactg   4440

aagttgaaag taattaatgc tgacaaaggg aaagaaagca gaaagagatt gagaattaga   4500

ggaagagaag tggaatcaaa ggtagagata cttatatatt caaagtgggg atgaaaagat   4560

cttcagttaa tggaacaaga actagaggat tagtgtattg ttcaaagcta taaaatcaaa   4620

ccaatagatg tattaaaaag tgatgtaact atcagacatt tggagagaga tggacaaagg   4680

aaagtggcga tagtgtaagt taaatcctta tcttttgtaa tggggaatta ttaaagatgt   4740

tgtaaagtca gtaagtcaag aaattattgc tcaaacatat tatttaaagt tagaaagtta   4800

gttaccagac gatctaaaat aaatattgtt aaaagcatta cctctaggga atgggattta   4860

gatttaaaaa gggtgggatg ggaaactgtg tttttcattt taagtccttc tgtactattt   4920

aattttttac cttgtgcatg tattactttg aaaaaatttt taataaaccc aaataaaaat   4980

cttccagtga cttcccattg attaagatgc aacccagcta aagcctttaa aatggttttc   5040

aaggtcctca agtatctagg tccacttgat gtgtccaggc tcatgatatc tccccacaag   5100

tctctatttc cagccagatt aagtatcttc cagttattaa aacacacttc acattctttt   5160

gtttgtatag gtgttccaca aaaaacaaag cctactgctg atctcaccat gtctgctgag   5220

taagcttacc atctagtggg ttttaatatt tgttgaatga aggaatgtcc aatacagcat   5280

tgaatgaagt ttgccaactt cattcttttc caagaaggcc tttgatgttt              5330


<210>  4889
<211>  738
<212>  PRT
<213>  Homosapiens

<400>  4889

Met Pro Ser Thr Val Leu Thr Ala Leu Tyr Arg Thr Val Pro Leu Ile 
1               5                   10                  15      


Lys Asn Ala Cys Val Phe Cys Ser Cys Glu Asp Asp Leu Ser Asp Asp 
            20                  25                  30          


Arg Glu Glu Leu Leu His Gly Ile Ser Glu Leu Asp Ile Ser Asn Ser 
        35                  40                  45              


Asp Cys Phe Pro Ser Gln Leu Leu Val His Gly Ala Leu Ala Phe Pro 
    50                  55                  60                  


Leu Gly Leu Asp Ser Tyr His Gly Cys Val Ile Ala Ala Ala Arg Tyr 
65                  70                  75                  80  


Gly Arg Gly Arg Val Val Val Thr Gly His Lys Val Leu Phe Thr Val 
                85                  90                  95      


Gly Lys Leu Gly Pro Phe Leu Leu Asn Ala Val Arg Trp Leu Asp Gly 
            100                 105                 110         


Gly Arg Arg Gly Lys Ile Val Val Gln Thr Glu Leu Arg Thr Leu Ser 
        115                 120                 125             


Gly Leu Leu Ala Val Gly Gly Ile Asp Thr Ser Ile Glu Pro Asn Leu 
    130                 135                 140                 


Thr Ser Asp Ala Ser Val Tyr Cys Phe Glu Pro Val Ser Glu Val Gly 
145                 150                 155                 160 


Val Lys Glu Leu Gln Glu Phe Val Ala Glu Gly Gly Gly Leu Phe Val 
                165                 170                 175     


Gly Ala Gln Ala Trp Trp Trp Ala Phe Lys Asn Pro Gly Val Ser Pro 
            180                 185                 190         


Leu Ala Arg Phe Pro Gly Asn Leu Leu Leu Asn Pro Phe Gly Ile Ser 
        195                 200                 205             


Ile Thr Ser Gln Ser Leu Asn Pro Gly Pro Phe Arg Thr Pro Lys Ala 
    210                 215                 220                 


Gly Ile Arg Thr Tyr His Phe Arg Ser Thr Leu Ala Glu Phe Gln Val 
225                 230                 235                 240 


Ile Met Gly Arg Lys Arg Gly Asn Val Glu Lys Gly Trp Leu Ala Lys 
                245                 250                 255     


Leu Gly Pro Asp Gly Ala Ala Phe Leu Gln Ile Pro Ala Glu Glu Ile 
            260                 265                 270         


Pro Ala Tyr Met Ser Val His Arg Leu Leu Arg Lys Leu Leu Ser Arg 
        275                 280                 285             


Tyr Arg Leu Pro Val Ala Thr Arg Glu Asn Pro Val Ile Asn Asp Cys 
    290                 295                 300                 


Cys Arg Gly Ala Met Leu Ser Leu Ala Thr Gly Leu Ala His Ser Gly 
305                 310                 315                 320 


Ser Asp Leu Ser Leu Leu Val Pro Glu Ile Glu Asp Met Tyr Ser Ser 
                325                 330                 335     


Pro Tyr Leu Arg Pro Ser Glu Ser Pro Ile Thr Val Glu Val Asn Cys 
            340                 345                 350         


Thr Asn Pro Gly Thr Arg Tyr Cys Trp Met Ser Thr Gly Leu Tyr Ile 
        355                 360                 365             


Pro Gly Arg Gln Ile Ile Glu Val Ser Leu Pro Glu Ala Ala Ala Ser 
    370                 375                 380                 


Ala Asp Leu Lys Ile Gln Ile Gly Cys His Thr Asp Asp Leu Thr Arg 
385                 390                 395                 400 


Ala Ser Lys Leu Phe Arg Gly Pro Leu Val Ile Asn Arg Cys Cys Leu 
                405                 410                 415     


Asp Lys Pro Thr Lys Ser Ile Thr Cys Leu Trp Gly Gly Leu Leu Tyr 
            420                 425                 430         


Ile Ile Val Pro Gln Asn Ser Lys Leu Gly Ser Val Pro Val Thr Val 
        435                 440                 445             


Lys Gly Ala Val His Ala Pro Tyr Tyr Lys Leu Gly Glu Thr Thr Leu 
    450                 455                 460                 


Glu Glu Trp Lys Arg Arg Ile Gln Glu Asn Pro Gly Pro Trp Gly Glu 
465                 470                 475                 480 


Leu Ala Thr Asp Asn Ile Ile Leu Thr Val Pro Thr Ala Asn Leu Arg 
                485                 490                 495     


Thr Leu Glu Asn Pro Glu Pro Leu Leu Arg Leu Trp Asp Glu Val Met 
            500                 505                 510         


Gln Ala Val Ala Arg Leu Gly Ala Glu Pro Phe Pro Leu Arg Leu Pro 
        515                 520                 525             


Gln Arg Ile Val Ala Asp Val Gln Ile Ser Val Gly Trp Met His Ala 
    530                 535                 540                 


Gly Tyr Pro Ile Met Cys His Leu Glu Ser Val Gln Glu Leu Ile Asn 
545                 550                 555                 560 


Glu Lys Leu Ile Arg Thr Lys Gly Leu Trp Gly Pro Val His Glu Leu 
                565                 570                 575     


Gly Arg Asn Gln Gln Arg Gln Glu Trp Glu Phe Pro Pro His Thr Thr 
            580                 585                 590         


Glu Ala Thr Cys Asn Leu Trp Cys Val Tyr Val His Glu Thr Val Leu 
        595                 600                 605             


Gly Ile Pro Arg Ser Arg Ala Asn Ile Ala Leu Trp Pro Pro Val Arg 
    610                 615                 620                 


Glu Lys Arg Val Arg Ile Tyr Leu Ser Lys Gly Pro Asn Val Lys Asn 
625                 630                 635                 640 


Trp Asn Ala Trp Thr Ala Leu Glu Thr Tyr Leu Gln Leu Gln Glu Ala 
                645                 650                 655     


Phe Gly Trp Glu Pro Phe Ile Arg Leu Phe Thr Glu Tyr Arg Asn Gln 
            660                 665                 670         


Thr Asn Leu Pro Thr Glu Asn Val Asp Lys Met Asn Leu Trp Val Lys 
        675                 680                 685             


Met Phe Ser His Gln Val Gln Lys Asn Leu Ala Pro Phe Phe Glu Ala 
    690                 695                 700                 


Trp Ala Trp Pro Ile Gln Lys Glu Val Ala Thr Ser Leu Ala Tyr Leu 
705                 710                 715                 720 


Pro Glu Trp Lys Glu Asn Ile Met Lys Leu Tyr Leu Leu Thr Gln Met 
                725                 730                 735     


Pro His 
        


<210>  4890
<211>  240
<212>  DNA
<213>  Homosapiens

<400>  4890
atggtacacc tgtataggga acttacaata aatggagctt gcaggactgg aagttgcctg     60

ggcgagttag tgaaatgtga gggcagggat gcagctgaaa agctggcggc ccagacagaa    120

gtctgcccca agcagcctga gccctcaggc accccccagc tccctgggag ctcccctcca    180

cctgccaacg tcagtgccac actggtgtct gaaaggaaaa acaggaacag gacagactaa    240


<210>  4891
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  4891

Met Val His Leu Tyr Arg Glu Leu Thr Ile Asn Gly Ala Cys Arg Thr 
1               5                   10                  15      


Gly Ser Cys Leu Gly Glu Leu Val Lys Cys Glu Gly Arg Asp Ala Ala 
            20                  25                  30          


Glu Lys Leu Ala Ala Gln Thr Glu Val Cys Pro Lys Gln Pro Glu Pro 
        35                  40                  45              


Ser Gly Thr Pro Gln Leu Pro Gly Ser Ser Pro Pro Pro Ala Asn Val 
    50                  55                  60                  


Ser Ala Thr Leu Val Ser Glu Arg Lys Asn Arg Asn Arg Thr Asp 
65                  70                  75                  


<210>  4892
<211>  2681
<212>  DNA
<213>  Homosapiens

<400>  4892
tgctcccaag atggggccct tcttgctcaa tgcggtgcgc tggctggcca gaggccagac     60

aggcaaagtt ggggtgaaca caaatctaaa agatctgtgt cctctcctat cggagcatgg    120

cctgcaatgc agcctggagc cccatctgaa cagcgacttg tgtgtctact gctgcaaggc    180

atacagtgac aaggaggcta agcagctgca ggagtttgtg gctgagggtg gggggctgct    240

gattgggggc caggcctggt ggtgggcctc ccagaaccct ggccactgcc ccttggctgg    300

cttccctggt aacatcatcc tcaactgctt tggcctcagc atcctgcctc agactctcaa    360

agcaggctgc ttccccgttc ccacccctga gatgagaagc taccacttcc gcaaggcgct    420

ctctcaattc caggctatac tgaaccacga gaatgggaac ttggaaaaga gctgtctggc    480

aaagttgaga gttgatggtg cagccttcct acagattcct gcggaggggg tccctgctta    540

catatccctg cacaggctcc tgaggaagat gctacgaggg tctggcctcc cagctgtgag    600

ccgggaaaat ccagttgcca gtgactccta tgaggctgcg gtgctctccc tggccactgg    660

gctggctcac tctggaactg actgctccca gctggcccag gggcttggca cctggacctg    720

ctcctccagt ttgtacccct caaaacaccc catcaccgtg gagatcaatg gaatcaaccc    780

aggcaacaat gattgctggg tgagtaccgg gctctacctc ctggaaggac aaaatgcaga    840

agtctcactg tctgaagctg ctgcctctgc tggcctgagg gtacagattg gctgccacac    900

cgatgacctt accaaggcca ggaagctatc tcgagccccc gtggtgactc accaatgctg    960

gatggacagg actgagcggt cagtctcctg cctctggggc ggcctcctct acgtcatcgt   1020

gcccaagggc agccaactag gccctgtgcc tgtcactatc aggggagctg tgcctgcccc   1080

atactacaag ctgggtaaga catcgctgga ggagtggaag aggcagatgc aggagaacct   1140

ggctccctgg ggagagctgg ccacggacaa catcatcctg acagtgccaa ccacaaacct   1200

tcaggccctg aaggaccccg agcctgtgct ccgcctctgg gatgagatga tgcaggctgt   1260

ggccaggctg gcggctgagc ccttcccttt ccgccgtcct gagaggattg tggctgatgt   1320

gcagatctca gctggctgga tgcattcagg ataccccatc atgtgccacc tggagtctgt   1380

gaaggagatc atcaatgaga tggacatgag gagcaggggt gtgtggggcc ccatccatga   1440

gctgggccac aaccaacagt ggcatggatg ggagttcccc ccacacacta ctgaggccac   1500

ctgtaacctt tggtcagtct acgtgcatga aacagtcctg gggatcccca gggctcaggc   1560

ccatgaggct ctgagccctc cagagcgaga gaggagaatc aaggcccacc tgggaaaggg   1620

agcccccctg tgtgactgga atgtatggac agccctggaa acatatctac agctccaaca   1680

ggccttcggg tgggagccat tcacccagct ctttgctgag taccagaccc tctctcacct   1740

ccccaaagac aacactggca ggatgaatct atgggtgaag aagttctctg aaaaagtgaa   1800

gaagaatctg gttcccttct ttgaggcctg gggctggcct atccagaagg aggtggctga   1860

cagcctggcc tccctaccag agtggcagga aaaccccatg caagtgtacc tccgtgccag   1920

gaagtaaagg atgccccaca aggcgggaga gaaaaggcag ggtcacgcca tcaactccac   1980

catggggctt tggccgtgtg ctcagtatct ggagcctgaa tcccgcttcc aagcctgacc   2040

actagatggt ggccacggtc ataagaaaaa atggaacccc tttctgtaaa aggtgccttg   2100

tgcttctttt tattgttttt ctgcctacgc tattgctttc cccaagagac tcacttcacc   2160

tcttagtctt ccagagagga tctttcatcc tgccatcctg aggcttctat ttttgaccaa   2220

tagctctaaa gaccacgggt tcccataaca acctgatatc cctttctcat ccctgccatc   2280

cctgaataag gcttctaatt tattatgctt taacaagttt tcaaatagca agcgagacac   2340

gctggaatag tggagagagc cccaaacact aaataagcca aattttgggg taaaaaaaat   2400

aaaaaaccaa gaaaccagac atagaagcag aacctaaagc atatttatca aaatatcttt   2460

gtttaaaaaa aatgtcttca gtggtcgtct tggctggtgg gattttaggt cattttaatt   2520

atctttataa aactttattc tctcgaattt taaaattaac atctatttct cttataatta   2580

aaaattaaat gttatatttt ttaaaaagta tagtttattt attccagtag taaaacatta   2640

ttgaaaaata aaggaaaagc atgcagaata ctagaaagag g                       2681


<210>  4893
<211>  638
<212>  PRT
<213>  Homosapiens

<400>  4893

Met Gly Pro Phe Leu Leu Asn Ala Val Arg Trp Leu Ala Arg Gly Gln 
1               5                   10                  15      


Thr Gly Lys Val Gly Val Asn Thr Asn Leu Lys Asp Leu Cys Pro Leu 
            20                  25                  30          


Leu Ser Glu His Gly Leu Gln Cys Ser Leu Glu Pro His Leu Asn Ser 
        35                  40                  45              


Asp Leu Cys Val Tyr Cys Cys Lys Ala Tyr Ser Asp Lys Glu Ala Lys 
    50                  55                  60                  


Gln Leu Gln Glu Phe Val Ala Glu Gly Gly Gly Leu Leu Ile Gly Gly 
65                  70                  75                  80  


Gln Ala Trp Trp Trp Ala Ser Gln Asn Pro Gly His Cys Pro Leu Ala 
                85                  90                  95      


Gly Phe Pro Gly Asn Ile Ile Leu Asn Cys Phe Gly Leu Ser Ile Leu 
            100                 105                 110         


Pro Gln Thr Leu Lys Ala Gly Cys Phe Pro Val Pro Thr Pro Glu Met 
        115                 120                 125             


Arg Ser Tyr His Phe Arg Lys Ala Leu Ser Gln Phe Gln Ala Ile Leu 
    130                 135                 140                 


Asn His Glu Asn Gly Asn Leu Glu Lys Ser Cys Leu Ala Lys Leu Arg 
145                 150                 155                 160 


Val Asp Gly Ala Ala Phe Leu Gln Ile Pro Ala Glu Gly Val Pro Ala 
                165                 170                 175     


Tyr Ile Ser Leu His Arg Leu Leu Arg Lys Met Leu Arg Gly Ser Gly 
            180                 185                 190         


Leu Pro Ala Val Ser Arg Glu Asn Pro Val Ala Ser Asp Ser Tyr Glu 
        195                 200                 205             


Ala Ala Val Leu Ser Leu Ala Thr Gly Leu Ala His Ser Gly Thr Asp 
    210                 215                 220                 


Cys Ser Gln Leu Ala Gln Gly Leu Gly Thr Trp Thr Cys Ser Ser Ser 
225                 230                 235                 240 


Leu Tyr Pro Ser Lys His Pro Ile Thr Val Glu Ile Asn Gly Ile Asn 
                245                 250                 255     


Pro Gly Asn Asn Asp Cys Trp Val Ser Thr Gly Leu Tyr Leu Leu Glu 
            260                 265                 270         


Gly Gln Asn Ala Glu Val Ser Leu Ser Glu Ala Ala Ala Ser Ala Gly 
        275                 280                 285             


Leu Arg Val Gln Ile Gly Cys His Thr Asp Asp Leu Thr Lys Ala Arg 
    290                 295                 300                 


Lys Leu Ser Arg Ala Pro Val Val Thr His Gln Cys Trp Met Asp Arg 
305                 310                 315                 320 


Thr Glu Arg Ser Val Ser Cys Leu Trp Gly Gly Leu Leu Tyr Val Ile 
                325                 330                 335     


Val Pro Lys Gly Ser Gln Leu Gly Pro Val Pro Val Thr Ile Arg Gly 
            340                 345                 350         


Ala Val Pro Ala Pro Tyr Tyr Lys Leu Gly Lys Thr Ser Leu Glu Glu 
        355                 360                 365             


Trp Lys Arg Gln Met Gln Glu Asn Leu Ala Pro Trp Gly Glu Leu Ala 
    370                 375                 380                 


Thr Asp Asn Ile Ile Leu Thr Val Pro Thr Thr Asn Leu Gln Ala Leu 
385                 390                 395                 400 


Lys Asp Pro Glu Pro Val Leu Arg Leu Trp Asp Glu Met Met Gln Ala 
                405                 410                 415     


Val Ala Arg Leu Ala Ala Glu Pro Phe Pro Phe Arg Arg Pro Glu Arg 
            420                 425                 430         


Ile Val Ala Asp Val Gln Ile Ser Ala Gly Trp Met His Ser Gly Tyr 
        435                 440                 445             


Pro Ile Met Cys His Leu Glu Ser Val Lys Glu Ile Ile Asn Glu Met 
    450                 455                 460                 


Asp Met Arg Ser Arg Gly Val Trp Gly Pro Ile His Glu Leu Gly His 
465                 470                 475                 480 


Asn Gln Gln Trp His Gly Trp Glu Phe Pro Pro His Thr Thr Glu Ala 
                485                 490                 495     


Thr Cys Asn Leu Trp Ser Val Tyr Val His Glu Thr Val Leu Gly Ile 
            500                 505                 510         


Pro Arg Ala Gln Ala His Glu Ala Leu Ser Pro Pro Glu Arg Glu Arg 
        515                 520                 525             


Arg Ile Lys Ala His Leu Gly Lys Gly Ala Pro Leu Cys Asp Trp Asn 
    530                 535                 540                 


Val Trp Thr Ala Leu Glu Thr Tyr Leu Gln Leu Gln Gln Ala Phe Gly 
545                 550                 555                 560 


Trp Glu Pro Phe Thr Gln Leu Phe Ala Glu Tyr Gln Thr Leu Ser His 
                565                 570                 575     


Leu Pro Lys Asp Asn Thr Gly Arg Met Asn Leu Trp Val Lys Lys Phe 
            580                 585                 590         


Ser Glu Lys Val Lys Lys Asn Leu Val Pro Phe Phe Glu Ala Trp Gly 
        595                 600                 605             


Trp Pro Ile Gln Lys Glu Val Ala Asp Ser Leu Ala Ser Leu Pro Glu 
    610                 615                 620                 


Trp Gln Glu Asn Pro Met Gln Val Tyr Leu Arg Ala Arg Lys 
625                 630                 635             


<210>  4894
<211>  1135
<212>  DNA
<213>  Homosapiens

<400>  4894
tgctcccaag atggggccct tcttgctcaa tgcggtgcgc tggctggcca gaggccagac     60

aggcaaagtt ggggtgaaca caaatctaaa agatctgtgt cctctcctat cggagcatgg    120

cctgcaatgc agcctggagc cccatctgaa cagcgacttg tgtgtctact gctgcaaggc    180

atacagtgac aaggaggcta agcagctgca ggagtttgtg gctgagggtg gggggctgct    240

gattgggggc caggcctggt ggtgggcctc ccagaaccct ggccactgcc ccttggctgg    300

cttccctggt aacatcatcc tcaactgctt tggcctcagc atcctgcctc agactctcaa    360

agcaggctgc ttccccgttc ccacccctga gatgagaagc taccacttcc gcaaggcgct    420

ctctcaattc caggctatac tgaaccacga gaatgggaac ttggaaaaga gctgtctggc    480

aaagttgaga gttgatggtg cagccttcct acagattcct gcggaggggg tccctgctta    540

catatccctg cacaggctcc tgaggaagat gctacgaggg tctggcctcc cagctgtgag    600

ccgggaaaat ccagttgcca gtgactccta tgaggctgcg gtgctctccc tggccactgg    660

gctggctcac tctggaactg actgctccca gctggcccag gggcttggca cctggacctg    720

ctcctccagt ttgtacccct caaaacaccc catcaccgtg gagatcaatg gaatcaaccc    780

aggcaacaat gattgctggg tgagtaccgg gctctacctc ctggaaggac aaaatgcaga    840

agtctcactg tctgaagctg ctgcctctgc tggcctgagg gtaaggtctg aacacccaca    900

tctgccacct ctcaaaaccg tagagctgtg tcattctcat ccactgtcta gttccagctc    960

atggcaatgc tgccaggagt acagagatgg attattctgc ccattttaca gattttacag   1020

atgaagcagc taaatttcag ggcatctaag tgagtgactg aagtgcctag tgttatcaag   1080

caagagaagc tcactgcaga atggactaga agccaaaact atgacacttg agttt        1135


<210>  4895
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  4895

Met Gly Pro Phe Leu Leu Asn Ala Val Arg Trp Leu Ala Arg Gly Gln 
1               5                   10                  15      


Thr Gly Lys Val Gly Val Asn Thr Asn Leu Lys Asp Leu Cys Pro Leu 
            20                  25                  30          


Leu Ser Glu His Gly Leu Gln Cys Ser Leu Glu Pro His Leu Asn Ser 
        35                  40                  45              


Asp Leu Cys Val Tyr Cys Cys Lys Ala Tyr Ser Asp Lys Glu Ala Lys 
    50                  55                  60                  


Gln Leu Gln Glu Phe Val Ala Glu Gly Gly Gly Leu Leu Ile Gly Gly 
65                  70                  75                  80  


Gln Ala Trp Trp Trp Ala Ser Gln Asn Pro Gly His Cys Pro Leu Ala 
                85                  90                  95      


Gly Phe Pro Gly Asn Ile Ile Leu Asn Cys Phe Gly Leu Ser Ile Leu 
            100                 105                 110         


Pro Gln Thr Leu Lys Ala Gly Cys Phe Pro Val Pro Thr Pro Glu Met 
        115                 120                 125             


Arg Ser Tyr His Phe Arg Lys Ala Leu Ser Gln Phe Gln Ala Ile Leu 
    130                 135                 140                 


Asn His Glu Asn Gly Asn Leu Glu Lys Ser Cys Leu Ala Lys Leu Arg 
145                 150                 155                 160 


Val Asp Gly Ala Ala Phe Leu Gln Ile Pro Ala Glu Gly Val Pro Ala 
                165                 170                 175     


Tyr Ile Ser Leu His Arg Leu Leu Arg Lys Met Leu Arg Gly Ser Gly 
            180                 185                 190         


Leu Pro Ala Val Ser Arg Glu Asn Pro Val Ala Ser Asp Ser Tyr Glu 
        195                 200                 205             


Ala Ala Val Leu Ser Leu Ala Thr Gly Leu Ala His Ser Gly Thr Asp 
    210                 215                 220                 


Cys Ser Gln Leu Ala Gln Gly Leu Gly Thr Trp Thr Cys Ser Ser Ser 
225                 230                 235                 240 


Leu Tyr Pro Ser Lys His Pro Ile Thr Val Glu Ile Asn Gly Ile Asn 
                245                 250                 255     


Pro Gly Asn Asn Asp Cys Trp Val Ser Thr Gly Leu Tyr Leu Leu Glu 
            260                 265                 270         


Gly Gln Asn Ala Glu Val Ser Leu Ser Glu Ala Ala Ala Ser Ala Gly 
        275                 280                 285             


Leu Arg Val Arg Ser Glu His Pro His Leu Pro Pro Leu Lys Thr Val 
    290                 295                 300                 


Glu Leu Cys His Ser His Pro Leu Ser Ser Ser Ser Ser Trp Gln Cys 
305                 310                 315                 320 


Cys Gln Glu Tyr Arg Asp Gly Leu Phe Cys Pro Phe Tyr Arg Phe Tyr 
                325                 330                 335     


Arg 
    


<210>  4896
<211>  2805
<212>  DNA
<213>  Homosapiens

<400>  4896
aaaacaaaaa caaaagaaaa cattttattg caatttgatt aacaaggaga caggagccca     60

gctcaaatct gtcccattgt acttatttta aagagttatt ttagtagaaa aggtgtaggg    120

agtggattct gtgattagta ggtgattgat agaaagaaaa ggaagggctg gaaaatcctc    180

gggcatgggc agttacctct tcatgcctcc tcatgggtcc catgtgcaaa ctcagaggga    240

gttagtatga aacatgcggt acaaatttag gctgtgtgtc agcaagctca ttctgcacaa    300

actctggttt tatctcttta tcttgacacc tgaagggtgt gcataatccc atcactcccc    360

aaaatatgcc ctacatgcag aatttaaatt catcctgcct ccttgactct gagggccact    420

tcctaccaca gctagggtcc cttttctgtc agcattcttt ctggagcttg cttatatcaa    480

acctaagaaa agcaactcca ggactccaga caaaacagat ctccacccat ctggcggcca    540

gaaagggaag ctctgggcaa agagggagag agaatcaacc tcactcactc tggatgggcc    600

tcctgtgtgt tcacagagga cagagcagag tcccccagct catcctcaat atcagcgtcc    660

ccagactggc ttaggtcctg ctagaagaac ccaggatttt gcctggcaga aagacacaag    720

acctttgcca ggatcagcct ggtctctcac caattcatgt caggtgaaga cttatagtgg    780

agctgtttaa atccttagaa aaatgatttt aaatgccttg aagtccaaat gactttggag    840

tgctaaaatt tcataagttt ccatgcctag cacatagaaa agggaagctg gggtttcatg    900

ggcatgtttg tctaatacct tccatctaca caacctcaca cgcacatcac aaagcatcac    960

aaagactcta atttctccaa cgcttggtgg aatcacctgt ccaggtacag attggctgcc   1020

acaccgatga ccttaccaag gccaggaagc tatctcgagc ccccgtggtg actcaccaat   1080

gctggatgga caggactgag cggtcagtct cctgcctctg gggcggcctc ctctacgtca   1140

tcgtgcccaa gggcagccaa ctaggccctg tgcctgtcac tatcagggga gctgtgcctg   1200

ccccatacta caagctgggt aagacatcgc tggaggagtg gaagaggcag atgcaggaga   1260

acctggctcc ctggggagag ctggccacgg acaacatcat cctgacagtg ccaaccacaa   1320

accttcaggc cctgaaggac cccgagcctg tgctccgcct ctgggatgag atgatgcagg   1380

ctgtggccag gctggcggct gagcccttcc ctttccgccg tcctgagagg attgtggctg   1440

atgtgcagat ctcagctggc tggatgcatt caggataccc catcatgtgc cacctggagt   1500

ctgtgaagga gatcatcaat gagatggaca tgaggagcag gggtgtgtgg ggccccatcc   1560

atgagctggg ccacaaccaa cagtggcatg gatgggagtt ccccccacac actactgagg   1620

ccacctgtaa cctttggtca gtctacgtgc atgaaacagt cctggggatc cccagggctc   1680

aggcccatga ggctctgagc cctccagagc gagagaggag aatcaaggcc cacctgggaa   1740

agggagcccc cctgtgtgac tggaatgtat ggacagccct ggaaacatat ctacagctcc   1800

aacaggcctt cgggtgggag ccattcaccc agctctttgc tgagtaccag accctctctc   1860

acctccccaa agacaacact ggcaggatga atctatgggt gaagaagttc tctgaaaaag   1920

tgaagaagaa tctggttccc ttctttgagg cctggggctg gcctatccag aaggaggtgg   1980

ctgacagcct ggcctcccta ccagagtggc aggaaaaccc catgcaagtg tacctccgtg   2040

ccaggaagta aaggatgccc cacaaggcgg gagagaaaag gcagggtcac gccatcaact   2100

ccaccatggg gctttggccg tgtgctcagt atctggagcc tgaatcccgc ttccaagcct   2160

gaccactaga tggtggccac ggtcataaga aaaaatggaa cccctttctg taaaaggtgc   2220

cttgtgcttc tttttattgt ttttctgcct acgctattgc tttccccaag agactcactt   2280

cacctcttag tcttccagag aggatctttc atcctgccat cctgaggctt ctatttttga   2340

ccaatagctc taaagaccac gggttcccat aacaacctga tatccctttc tcatccctgc   2400

catccctgaa taaggcttct aatttattat gctttaacaa gttttcaaat agcaagcgag   2460

acacgctgga atagtggaga gagccccaaa cactaaataa gccaaatttt ggggtaaaaa   2520

aaataaaaaa ccaagaaacc agacatagaa gcagaaccta aagcatattt atcaaaatat   2580

ctttgtttaa aaaaaatgtc ttcagtggtc gtcttggctg gtgggatttt aggtcatttt   2640

aattatcttt ataaaacttt attctctcga attttaaaat taacatctat ttctcttata   2700

attaaaaatt aaatgttata ttttttaaaa agtatagttt atttattcca gtagtaaaac   2760

attattgaaa aataaaggaa aagcatgcag aatactagaa agagg                   2805


<210>  4897
<211>  321
<212>  PRT
<213>  Homosapiens

<400>  4897

Met Asp Arg Thr Glu Arg Ser Val Ser Cys Leu Trp Gly Gly Leu Leu 
1               5                   10                  15      


Tyr Val Ile Val Pro Lys Gly Ser Gln Leu Gly Pro Val Pro Val Thr 
            20                  25                  30          


Ile Arg Gly Ala Val Pro Ala Pro Tyr Tyr Lys Leu Gly Lys Thr Ser 
        35                  40                  45              


Leu Glu Glu Trp Lys Arg Gln Met Gln Glu Asn Leu Ala Pro Trp Gly 
    50                  55                  60                  


Glu Leu Ala Thr Asp Asn Ile Ile Leu Thr Val Pro Thr Thr Asn Leu 
65                  70                  75                  80  


Gln Ala Leu Lys Asp Pro Glu Pro Val Leu Arg Leu Trp Asp Glu Met 
                85                  90                  95      


Met Gln Ala Val Ala Arg Leu Ala Ala Glu Pro Phe Pro Phe Arg Arg 
            100                 105                 110         


Pro Glu Arg Ile Val Ala Asp Val Gln Ile Ser Ala Gly Trp Met His 
        115                 120                 125             


Ser Gly Tyr Pro Ile Met Cys His Leu Glu Ser Val Lys Glu Ile Ile 
    130                 135                 140                 


Asn Glu Met Asp Met Arg Ser Arg Gly Val Trp Gly Pro Ile His Glu 
145                 150                 155                 160 


Leu Gly His Asn Gln Gln Trp His Gly Trp Glu Phe Pro Pro His Thr 
                165                 170                 175     


Thr Glu Ala Thr Cys Asn Leu Trp Ser Val Tyr Val His Glu Thr Val 
            180                 185                 190         


Leu Gly Ile Pro Arg Ala Gln Ala His Glu Ala Leu Ser Pro Pro Glu 
        195                 200                 205             


Arg Glu Arg Arg Ile Lys Ala His Leu Gly Lys Gly Ala Pro Leu Cys 
    210                 215                 220                 


Asp Trp Asn Val Trp Thr Ala Leu Glu Thr Tyr Leu Gln Leu Gln Gln 
225                 230                 235                 240 


Ala Phe Gly Trp Glu Pro Phe Thr Gln Leu Phe Ala Glu Tyr Gln Thr 
                245                 250                 255     


Leu Ser His Leu Pro Lys Asp Asn Thr Gly Arg Met Asn Leu Trp Val 
            260                 265                 270         


Lys Lys Phe Ser Glu Lys Val Lys Lys Asn Leu Val Pro Phe Phe Glu 
        275                 280                 285             


Ala Trp Gly Trp Pro Ile Gln Lys Glu Val Ala Asp Ser Leu Ala Ser 
    290                 295                 300                 


Leu Pro Glu Trp Gln Glu Asn Pro Met Gln Val Tyr Leu Arg Ala Arg 
305                 310                 315                 320 


Lys 
    


<210>  4898
<211>  2127
<212>  DNA
<213>  Homosapiens

<400>  4898
cagaccacct gagctcagga gctcaagacc agcctgggca acatggcaaa accctgtctc     60

tactaacact ataaaaagtt agctgggcgt gttggtgcat gctgtagtcc cagctactca    120

ggaggctgag ccacgagaat cgcttgaacc tgggagatgg aggttgaagt gagccaagat    180

cgcaccattg cactccagcc tggggaaaaa aaaaagccag gcctcctaat gtactcattt    240

aaacatcact tgtgtccacc tgggttcaga attgcgctgg acatgggata cacaaagcgg    300

gagtggaatt ttcaggaagc agctgtgctg tgggtgacgg tcatacttta ttctctaaaa    360

ctctccagtt tcaattggcc tcttggtgcc aaagcaccat ggcgtgttac acctatcaga    420

tcgggcacac tgccccttct tcccaaccta cgagctgaaa tggccagcac tgcgccttcc    480

agaacccagc gtagatgcac agctgccacg gaggtaggaa gaatgattcg tttgccacca    540

aaagcccagt ttctccaaca ggtgaatccc taggccagcc cggccccttc ccacacaccc    600

ctaccccgag acgggtgcag aatcagcagc ggggatcatc cagagactct cgcagtccac    660

ggcaggtgtc ggagtgggcc tcattccaga gttgtggtgg ccgctccacc tggcgagctt    720

cgaggggact ccggcaggcg ctcgctgtgg ggtcctccca ccagtcttct cagcacagga    780

acggtgcctt cacattggtc ttccggggct taaaagcata tcattcctgc ttgctcttca    840

gatgcaaact ccccctccaa ggatacctcc aggttccctg ccagctcact tgactcacat    900

ggcaatggtc accgggctgc ctgagcccaa atcaagcacc gtttattagg gggaagctcc    960

gttatccaga aagctcatct ttgaagagct acccatttcc tgccaaagtt gtggcgggaa   1020

ggccttaggt actagaaaac cttggggaat ggcaattaaa ggattatcat tcttacttat   1080

ttgtttggat aagcagcaat cacccttcgg atgcttattg gtgagaatat ttctaaaagt   1140

gtcctgcaca tttccctgct ttgatgaatg gaacggcagg gcaggattta actgtctgat   1200

ggctacggtt ttgggaaagt gccagaacct ccacgtcagc caccccagag ccacaggcag   1260

ggtatgagcc acagcaatgg gccccaagaa agagccccac acccaccatg gtccacggaa   1320

gacgctgctt actggccccg ggttacctgg agtcatgtgc attctcctta catcaagtga   1380

agataatatt ttgtttcctt cccacttttt ctctaacaca agccacccca gttctccctt   1440

ctgacaacag gcaagtggac cctagtagac cttccagaaa agccttagag agcaccccca   1500

aatgctcaca tttgtcagct gtaattccac cctcagttaa aacctgattc tcaatgtgac   1560

ttggccaacg cagcttgcaa agcaagaacg tcttcatcta aggttgaaaa catcagttgt   1620

ttgggttgtg agaaaagaaa agcccacaag gtttccgagg cttggtgctg tttctcactg   1680

tcctcagctc ctgattctgc agctggttct ctctccaagc actagcaaaa ccctgcccta   1740

ggagccccca gactctgaga gcccatgacc aaaaagaaaa ggaaagccaa gttggggaag   1800

aacaggggcc cccaactcca cagccctcca ctctgcccag agggcccacc ctgggctgcc   1860

tggaaccccc taaagttgcc acccccgcaa cacagtagtg gggcagttcc tggcagcgcc   1920

tgcagcccat gggctggctc tgtacccgca gccccgccaa gcgtctgtta tcttatttac   1980

tggaatctgc acagccaggc tctagctcac cggtgactaa ggagctgcag ccattattac   2040

caggcagatg gcagactccc taaaagcaga cattaaacaa taaaatgcca ccacatacct   2100

tgcccacaaa ataaaatcaa aacaaac                                       2127


<210>  4899
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  4899

Met Gly Tyr Thr Lys Arg Glu Trp Asn Phe Gln Glu Ala Ala Val Leu 
1               5                   10                  15      


Trp Val Thr Val Ile Leu Tyr Ser Leu Lys Leu Ser Ser Phe Asn Trp 
            20                  25                  30          


Pro Leu Gly Ala Lys Ala Pro Trp Arg Val Thr Pro Ile Arg Ser Gly 
        35                  40                  45              


Thr Leu Pro Leu Leu Pro Asn Leu Arg Ala Glu Met Ala Ser Thr Ala 
    50                  55                  60                  


Pro Ser Arg Thr Gln Arg Arg Cys Thr Ala Ala Thr Glu Val Gly Arg 
65                  70                  75                  80  


Met Ile Arg Leu Pro Pro Lys Ala Gln Phe Leu Gln Gln Val Asn Pro 
                85                  90                  95      


<210>  4900
<211>  2127
<212>  DNA
<213>  Homosapiens

<400>  4900
cagaccacct gagctcagga gctcaagacc agcctgggca acatggcgaa accctgtctc     60

tactaacact ataaaaagtt agctgggcgt gttggtgcat gctgtagtcc cagctactca    120

ggaggctgag ccacgagaat cgcttgaacc tgggagatgg aggttgaagt gagccaagat    180

cgcaccattg cactccagcc tggggaaaaa aaaaagccag gcctcctaat gtactcattt    240

aaacatcact tgtgtccacc tgggttcaga attgcgctgg acatgggata cacaaagcgg    300

gagtggaatt ttcaggaagc agctgtgctg tgggtgacgg tcatacttta ttctctaaaa    360

ctctccagtt tcaattggcc tcttggtgcc aaagcaccat ggcgtgttac acctatcaga    420

tcgggcacac tgccccttct tcccaaccta cgagctgaaa tggccagcac tgcgccttcc    480

agaacccagc gtagatgcac agctgccacg gaggtaggaa gaatgattcg tttgccacca    540

aaagcccagt ttctccaaca ggtgaatccc taggccagcc cggccccttc ccacacaccc    600

ctaccccgag acgggtgcag aatcagcagc ggggatcatc cagagactct cgcagtccac    660

ggcaggtgtc ggagtgggcc tcattccaga gttgtggtgg ccgctccacc tggcgagctt    720

cgaggggact ccggcaggcg ctcgctgtgg ggtcctccca ccagtcttct cagcacagga    780

acggtgcctt cacattggtc ttccggggct taaaagcata tcattcctgc ttgctcttca    840

gatgcaaact ccccctccaa ggatacctcc aggttccctg ccagctcact tgactcacat    900

ggcaatggtc accgggctgc ctgagcccaa atcaagcacc gtttattagg gggaagctcc    960

gttatccaga aagctcatct ttgaagagct acccatttcc tgccaaagtt gtggcgggaa   1020

ggccttaggt actagaaaac cttggggaat ggcaattaaa ggattatcat tcttacttat   1080

ttgtttggat aagcagcaat cacccttcgg atgcttattg gtgagaatat ttctaaaagt   1140

gtcctgcaca tttccctgct ttgatgaatg gaacggcagg gcaggattta actgtctgat   1200

ggctacggtt tcgggaaagt gccagaacct ccacgtcagc caccccagag ccacaggcag   1260

ggtatgagcc acagcaatgg gccccaagaa agagccccac acccaccatg gtccacggaa   1320

gacgctgctt actggccccg ggttacctgg agtcatgtgc attctcctta catcaagtga   1380

agataatatt ttgtttcctt cccacttttt ctctaacaca agccacccca gttctccctt   1440

ctgacaacag gcaagtggac cctagtagac cttccagaaa agccttagag agcaccccca   1500

aatgctcaca tttgtcagct gtaattccac cctcagttaa aacctgattc tcaatgtgac   1560

ttggccaacg cagcttgcaa agcaagaacg tcttcatcta aggttgaaaa catcagttgt   1620

ttgggttgtg agaaaagaaa agcccacaag gtttccgagg cttggtgctg tttctcactg   1680

tcctcagctc ctgattctgc agctggttct ctctccaagc actagcaaaa ccctgcccta   1740

ggagccccca gactctgaga gcccatgacc aaaaagaaaa ggaaagccaa gttggggaag   1800

aacaggggcc cccaactcca cagccctcca ctctgcccag agggcccacc ctgggctgcc   1860

tggaaccccc taaagttgcc acccccgcaa cacagtagtg gggcagttcc tggcagcgcc   1920

tgcagcccat gggctggctc tgtacccgca gccccgccaa gcgtctgtta tcttatttac   1980

tggaatctgc acagccaggc tctagctcac cggtgactaa ggagctgcag ccattattac   2040

caggcagatg gcagactccc taaaagcaga cattaaacaa taaaatgcca ccacatacct   2100

tgcccacaaa ataaaatcaa aacaaac                                       2127


<210>  4901
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  4901

Met Gly Tyr Thr Lys Arg Glu Trp Asn Phe Gln Glu Ala Ala Val Leu 
1               5                   10                  15      


Trp Val Thr Val Ile Leu Tyr Ser Leu Lys Leu Ser Ser Phe Asn Trp 
            20                  25                  30          


Pro Leu Gly Ala Lys Ala Pro Trp Arg Val Thr Pro Ile Arg Ser Gly 
        35                  40                  45              


Thr Leu Pro Leu Leu Pro Asn Leu Arg Ala Glu Met Ala Ser Thr Ala 
    50                  55                  60                  


Pro Ser Arg Thr Gln Arg Arg Cys Thr Ala Ala Thr Glu Val Gly Arg 
65                  70                  75                  80  


Met Ile Arg Leu Pro Pro Lys Ala Gln Phe Leu Gln Gln Val Asn Pro 
                85                  90                  95      


<210>  4902
<211>  906
<212>  DNA
<213>  Homosapiens

<400>  4902
ccctcctggt gagatcccat cacgtcccct ggcctccagt gtcatctgct ctgcatgata     60

tctccagggg gacctctctg ctgggctcca ggccgcatgg ctgtgggtga ccagcatcat    120

gtcccaccgg gtcccctgca gtcccagtgc acctgcctgc tcatccaggg acctgtcctc    180

actgcctgct gcctgcactg tgtggaagga cagaggctaa acgacgaagc ctcgagctct    240

ggtctcatgg aaatggcagc ctgcccacca cccacgcttg cccagccttt cttcacgcag    300

gaagaatatt tctcagccct ccgttctcaa gacagatgag tgctttagaa agaggactct    360

gcagcggtga ggaggatgga atgacaggca aagcacgcag gaccaggaga tggcttcgtt    420

ccctcaatca ctcatccaaa gacgtttaat gagcacctat tgtgtgtcag gcattgtacc    480

gggcaatggg gatatcgtag tcagtaataa gtgaggagag atgagttcat ttgtgagagg    540

ctctgaccag tggaatcaga ggaagggagt tcccctgggt gggccaggtt caaagacatt    600

ttggaagtag aatctgcaga acatgatgat cttttggaaa cagggcaggg acgtgaatga    660

gcacgtaatg tccccatggg tttgtctttc cgaaggttta aaatcctcaa gaataaggaa    720

cataggcatg tgtcgtaacg gtctccacag tgggggagta ttatgttagt gcacctgcat    780

gttaactctg ctcatgaagg ggccacgtct tcaccaccac aaagcctcaa gcatgcatat    840

ctggtccctc caaccccctc cctattgagg tgcaataaag gcccatgttt ctcctagtat    900

gggaac                                                               906


<210>  4903
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  4903

Met Ala Val Gly Asp Gln His His Val Pro Pro Gly Pro Leu Gln Ser 
1               5                   10                  15      


Gln Cys Thr Cys Leu Leu Ile Gln Gly Pro Val Leu Thr Ala Cys Cys 
            20                  25                  30          


Leu His Cys Val Glu Gly Gln Arg Leu Asn Asp Glu Ala Ser Ser Ser 
        35                  40                  45              


Gly Leu Met Glu Met Ala Ala Cys Pro Pro Pro Thr Leu Ala Gln Pro 
    50                  55                  60                  


Phe Phe Thr Gln Glu Glu Tyr Phe Ser Ala Leu Arg Ser Gln Asp Arg 
65                  70                  75                  80  


<210>  4904
<211>  984
<212>  DNA
<213>  Homosapiens

<400>  4904
atgacactgg aggccagggg acgtgatggg atctcaccag gagggcctga gaagggaaag     60

gcaggtggaa tggacagcgc ctgcaaggtg aggcgcccct acaaggtgag gcacccctgc    120

aaggggaccg cccagccccc aacacctggg cactgcccca ctcccctcac ctgtcacctc    180

atcacccagc ccacggtacc ctgcagcttg gctccaggcc caccttccag ggctcccctc    240

gaagcctcct gtccgctcag ccccaggtgc ggcatccgca ggtcccgtgg gttccacctt    300

cccagcgcct ctgaggcctc gcggccgctt ctccccgcgc ccacccgcgc ccgagcgaag    360

tcccgcagcg aaatctccgg gaggccgcgc ctctcctgtc ccagccccgg ggtctcccgt    420

ctcaccccac gaaaaggcaa tctgggccgt gacctccgag gcccccagat ccgcccccga    480

acgaggcggg cagggagagg acgcgtggcc cccacccact cagctcccag cgcggagtcc    540

cgggaccacc ttgcggagaa aagtccgccc cgcacctgcc acggaggaga agctgggggt    600

gggggaccca ggaactgcgg ctcggcccag gcgggggacc tggaaaaacc tcgcgcgggg    660

cgactgggga cggcggcgag gagggaggct ccgcggacgc gcgtggggcg gcccgggaca    720

gcgggagcca ggcagaggag gcggcggccc ggggcatccg agctcaagcg ccgctccgcc    780

gacgtgcatc cggccgggcg cctccccctt tacttggctt gctcccccac gaccaccctc    840

ggcccaccct ccaacaacag gggcaccccg cgctccccct gcgaggccac gcgagccccg    900

accccccgcg caccgggctg cagacgggag acgggctcca gcctcaagag gccccagact    960

tgctggaaag gcagatgtgt ttaa                                           984


<210>  4905
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  4905

Met Thr Leu Glu Ala Arg Gly Arg Asp Gly Ile Ser Pro Gly Gly Pro 
1               5                   10                  15      


Glu Lys Gly Lys Ala Gly Gly Met Asp Ser Ala Cys Lys Val Arg Arg 
            20                  25                  30          


Pro Tyr Lys Val Arg His Pro Cys Lys Gly Thr Ala Gln Pro Pro Thr 
        35                  40                  45              


Pro Gly His Cys Pro Thr Pro Leu Thr Cys His Leu Ile Thr Gln Pro 
    50                  55                  60                  


Thr Val Pro Cys Ser Leu Ala Pro Gly Pro Pro Ser Arg Ala Pro Leu 
65                  70                  75                  80  


Glu Ala Ser Cys Pro Leu Ser Pro Arg Cys Gly Ile Arg Arg Ser Arg 
                85                  90                  95      


Gly Phe His Leu Pro Ser Ala Ser Glu Ala Ser Arg Pro Leu Leu Pro 
            100                 105                 110         


Ala Pro Thr Arg Ala Arg Ala Lys Ser Arg Ser Glu Ile Ser Gly Arg 
        115                 120                 125             


Pro Arg Leu Ser Cys Pro Ser Pro Gly Val Ser Arg Leu Thr Pro Arg 
    130                 135                 140                 


Lys Gly Asn Leu Gly Arg Asp Leu Arg Gly Pro Gln Ile Arg Pro Arg 
145                 150                 155                 160 


Thr Arg Arg Ala Gly Arg Gly Arg Val Ala Pro Thr His Ser Ala Pro 
                165                 170                 175     


Ser Ala Glu Ser Arg Asp His Leu Ala Glu Lys Ser Pro Pro Arg Thr 
            180                 185                 190         


Cys His Gly Gly Glu Ala Gly Gly Gly Gly Pro Arg Asn Cys Gly Ser 
        195                 200                 205             


Ala Gln Ala Gly Asp Leu Glu Lys Pro Arg Ala Gly Arg Leu Gly Thr 
    210                 215                 220                 


Ala Ala Arg Arg Glu Ala Pro Arg Thr Arg Val Gly Arg Pro Gly Thr 
225                 230                 235                 240 


Ala Gly Ala Arg Gln Arg Arg Arg Arg Pro Gly Ala Ser Glu Leu Lys 
                245                 250                 255     


Arg Arg Ser Ala Asp Val His Pro Ala Gly Arg Leu Pro Leu Tyr Leu 
            260                 265                 270         


Ala Cys Ser Pro Thr Thr Thr Leu Gly Pro Pro Ser Asn Asn Arg Gly 
        275                 280                 285             


Thr Pro Arg Ser Pro Cys Glu Ala Thr Arg Ala Pro Thr Pro Arg Ala 
    290                 295                 300                 


Pro Gly Cys Arg Arg Glu Thr Gly Ser Ser Leu Lys Arg Pro Gln Thr 
305                 310                 315                 320 


Cys Trp Lys Gly Arg Cys Val 
                325         


<210>  4906
<211>  1383
<212>  DNA
<213>  Homosapiens

<400>  4906
atggtcccgg cgcctcctcc gtgcgggccc cgccccgggc cgcgctcgca caaactccca     60

cgcgagtgct tccccgcgtc cgggcccggg agcccggttc tttgcgctgc agccctcagg    120

cgaccgcgcg gaggccgctg ccgccgtggt ggggacccgc gcccctccgc gcacttgaag    180

ctcagcgcgg cttccgattg gcgcgcgcag cgggggcccg gggagggccg cgggctccgc    240

cattggccga ggggcgcacc tgtcaccgct caacctgggg cctctgcccg ccctcccctg    300

ggtgcggagc cggacggcgg gcactggcaa cccccgggcc cctggagagc cccgcggcgg    360

cccaagaccc gctcccgaga cacgtgggcc cctccggact tggttggtcc ctggagccag    420

ctgcgcgcgt cctctccggc ctccttgtcg gcgctggagt gggtccacgt ctgccttgcg    480

gagcgcggtg gttccacgct cctgagcgcc cacgctgcgc agacctggcc gctctgcgag    540

gcgacggcag cgcactgaag accgtggtgt ttcccaagcc ctccctgctc tcgggcctcc    600

agggcgcagc aggggagggt tttgtccccg tggccaaagc tctgcaggtc gaaccttatc    660

tgctatggga aggccccgca ttttcagatt cacgcagggc cctctgcaga ctgttggcag    720

aaaaaaggta gccaccaaac acatgcataa gctggacttt tcccagaatg ctgcagcaga    780

actaccctcc agatagacac tagcctgcgg gccacagtgc tacgtgagtc ttgcaaagag    840

gagatcttta tggcgaggct gagagcactg cctgcatgct ttaccagagc ccagcctcca    900

gcctccacgg aaaatgtgtt ttggaatcaa cactctttgc aaaggctcca cactgctttc    960

tggtagcatt ggcctgggcg cccaggcact cctttagaac ccacctgttc cccccaccca   1020

ccctagtggg aggaggagag ggttacactg acagataccg gcagctctgc aacccgggaa   1080

caacgcagac aacatacaac tcgacagagt cacagaaggt ggcgtccatc gcgcctggat   1140

ggtgactact gccctgcggg ctgctgggtg ggtgaaacac acagggaaga agcacaaata   1200

cacacacaga tgtggctcag ggacatttga atgcttcagt gtgtgaattt tttagcgcat   1260

tctgactcga aattatggct gaatagtggc gcactaatgt ccaagtccat gttcgataat   1320

ggcaggaagt ctgcactaat tggtctattt agtagttgct gaggtggcaa aagctgcagc   1380

tgc                                                                 1383


<210>  4907
<211>  185
<212>  PRT
<213>  Homosapiens

<400>  4907

Met Val Pro Ala Pro Pro Pro Cys Gly Pro Arg Pro Gly Pro Arg Ser 
1               5                   10                  15      


His Lys Leu Pro Arg Glu Cys Phe Pro Ala Ser Gly Pro Gly Ser Pro 
            20                  25                  30          


Val Leu Cys Ala Ala Ala Leu Arg Arg Pro Arg Gly Gly Arg Cys Arg 
        35                  40                  45              


Arg Gly Gly Asp Pro Arg Pro Ser Ala His Leu Lys Leu Ser Ala Ala 
    50                  55                  60                  


Ser Asp Trp Arg Ala Gln Arg Gly Pro Gly Glu Gly Arg Gly Leu Arg 
65                  70                  75                  80  


His Trp Pro Arg Gly Ala Pro Val Thr Ala Gln Pro Gly Ala Ser Ala 
                85                  90                  95      


Arg Pro Pro Leu Gly Ala Glu Pro Asp Gly Gly His Trp Gln Pro Pro 
            100                 105                 110         


Gly Pro Trp Arg Ala Pro Arg Arg Pro Lys Thr Arg Ser Arg Asp Thr 
        115                 120                 125             


Trp Ala Pro Pro Asp Leu Val Gly Pro Trp Ser Gln Leu Arg Ala Ser 
    130                 135                 140                 


Ser Pro Ala Ser Leu Ser Ala Leu Glu Trp Val His Val Cys Leu Ala 
145                 150                 155                 160 


Glu Arg Gly Gly Ser Thr Leu Leu Ser Ala His Ala Ala Gln Thr Trp 
                165                 170                 175     


Pro Leu Cys Glu Ala Thr Ala Ala His 
            180                 185 


<210>  4908
<211>  527
<212>  DNA
<213>  Homosapiens

<400>  4908
ccgaatgaga catcctgtgt tgatcgcagc cgtctcccag catgtggagc aacactagga     60

ccgtggtaga tgttcagtca tgttcgctga aggaagaagg gagtgaatga atgtcttctc    120

tgaggatagc tgagcatccg tgcatccgtc tggccatgag aacttggttg cgctcacatg    180

aggatcctga gcagagtcgc agtgcacgct ctgcggggag ccggaaggga gagatgggga    240

gagatgatcc caacgtgtga ctctaaaagc cgaatactaa aggcttctgt atactcaggg    300

tcacagaagc tcaaccgtgt ccattggaaa ggctcttact cgtaatttaa aacacaaaaa    360

tgaaaaaaag atacagacag cccaactaaa tccttgaaat gcagcgtggc gtgaaaatgg    420

agcggcattt tagttaacga gggtctggat gccattcaca ggaatgcagt ttctacaggg    480

ttctgctttg cagagacctc tcctgataat aataataaat ttactca                  527


<210>  4909
<211>  49
<212>  PRT
<213>  Homosapiens

<400>  4909

Met Ser Ser Leu Arg Ile Ala Glu His Pro Cys Ile Arg Leu Ala Met 
1               5                   10                  15      


Arg Thr Trp Leu Arg Ser His Glu Asp Pro Glu Gln Ser Arg Ser Ala 
            20                  25                  30          


Arg Ser Ala Gly Ser Arg Lys Gly Glu Met Gly Arg Asp Asp Pro Asn 
        35                  40                  45              


Val 
    


<210>  4910
<211>  2887
<212>  DNA
<213>  Homosapiens

<400>  4910
aaaattttat taaccagcat gtttggtata tttaaagcag tgactgagtg tgtttgagtg     60

agtggctgag tgcagtgtct tttgtttaaa cacactgcct cgtgtctttg tagctgattc    120

agagagtttg aattgtgggg tgggagacta acttcagctc caggctgcag taatgtgttg    180

gtagttacac ttgaggcatt tttttgttgt tgttaattaa ctctatagtc tcaaactatt    240

tttgcaaata tatcattttt cctaattggt tcttgacgtg cagtggactg gctctgtgaa    300

tgattggcag ggtcttagtt ttgcgagagt atttccttct aagaattatt gtgatctgca    360

gaaacagcca tttgattcaa aaatcatgta gaaaaggagt aggagaagca aaacgtttca    420

tttttgggcc ttaaccattt gaaatgtttg gactttaaac ataaagccat ggagtttata    480

aagccaagta accatttgat atggataata atatctactc tagagagagt atatatatgc    540

acattgattt ttaatgctgt taagatactt ttgtaaaact gtaggaacaa gagtaattag    600

accaaattga agcttagggg acagtaaagt ggttgctttc catttagggt aaccatgcat    660

gtggttagtc ctctcctcct gagattcaga accagttgac tgtcccctta ggtgtataag    720

gagaaaagtt gacatgtctg ggacctctga catgtgtaca catgcttgca cacatgcaca    780

cacagtgaat gttttaagtt atacaaacat aagaccttaa gatgcaaaga gccagaatat    840

tctaaagagg tgatgaacag agggggtgga aactgcatca cagatgtttt ccaagggcca    900

gggtggaatc tgagctctag tgtctgactt tgagatgcat tatattttta acacataaat    960

gaggggatcc atatcacatt ctttcttgtg gaccaccaaa ttgaaggctt tcttgtaatt   1020

cacaagcagc agctctccag catctctccg tagcctgggt gaagtcccag aagctggtgt   1080

gcatcatttt ccaaggtggc agagctgctt gctctgcaga tcattccttt gagagaggag   1140

tacaagtgaa gaaacaagga ggcacttcct gtaggagcac tgatgtgcct tgtccacact   1200

cccctctgag ctttactggt aagagagctc cgactgaaca tgctgagcag ttgagcactt   1260

ttccatcagc aacaacagcg aggatggaaa tggaaaggaa ccgaactaaa atgcatttcc   1320

ctttgcaggg cagagagcta agctcttagg aatagtgtta tagaaataag caccctaact   1380

tcaattcctg aaaatgttgg ttaatggaga gaattttgga gtttcactta atattttccc   1440

atcggtcgcc ataaataagt cttcaggcgc tcctagaaga gtcccagccc aaggctcgat   1500

taaggaccac actgcaggtc tgaggctcac tgctctgagt cctgaacacc agagccctgc   1560

agagagtggt gataacacat catctctgca aagaggaacc tctcccccgg ccgccacttc   1620

actcaggctt ctactgagca gcaaggacag cctgggtttc aaatgccact tcccctgctt   1680

tagggatcca ggtgtcctga tagcgtgacc ctgctgaggc aaggtatcaa ctccgagagt   1740

gactgagtca ctgagcgtgg cacatgaaca aacgtcatga caaagattct ctgagtgaag   1800

ttaacaccac gtattttacc tttgcaaaaa acaaactggc accctgagtt ctaactacgg   1860

acggacgata tctttgcctc cacacccaga ttcctggaaa tggctaacgt ttcctttcta   1920

ggggaagggt cgaggaatac tcaagtgcta gcttagcagc tttgttcagt ccagatcaga   1980

gctgttaggt aaaggcctaa ccacctccct gcagtctctt atatctcaag ctttaggaac   2040

ccatttctaa atgtacacta gcggagaatt tatattgtca gccttgatta ccataggaca   2100

ggcagaaagg cgataatttg tatcttttaa tataaaagaa gcttttaact tttccagcct   2160

attataataa ctgagttata ttcactgtgg ctcaaactaa ttggcattgt ggaacatttc   2220

tttaccttca aagttttctc caccaatcat ttcagttcta ttgcagtcct ggtgccatat   2280

gtcccctgca aattgtgaaa gtaattagtg acaaaatagc agcctgctcc ttttcaatgg   2340

cgaaactgtc ggcattagca gttttgggta agctggcggt actataacac gtactggaaa   2400

cctgttcctc atcaccacct accagattct ggaaatgccg tcttctagaa aacgatggcg   2460

tttgtggtgg tcttcttttg aaaggaacag taatttgtgt ggatattgtt aaagtgttta   2520

aagaatattt tgacaattaa gtttacattt tacaattgct ttatttttta ttaaaatagt   2580

tgtatataaa tattacccta tttcactgtt gttcaagtaa atctaaacct tgtagacaag   2640

tgagtcatct gatatgtata gaagctgtga tatatagagt acatttattg tgtaaatgtt   2700

tatgaatata attgttcctg tgtttttata agttggggat attttgttgt tttacggcaa   2760

caaaatttat tgcatttaaa tggtttttat gtaatagaaa tcacgcaaaa tagtgaagga   2820

tttaaaatat gtatatgata catgtaaatg tacaaacttt agaaagaaat aaatccaaca   2880

aatttca                                                             2887


<210>  4911
<211>  104
<212>  PRT
<213>  Homosapiens

<400>  4911

Met Leu Val Asn Gly Glu Asn Phe Gly Val Ser Leu Asn Ile Phe Pro 
1               5                   10                  15      


Ser Val Ala Ile Asn Lys Ser Ser Gly Ala Pro Arg Arg Val Pro Ala 
            20                  25                  30          


Gln Gly Ser Ile Lys Asp His Thr Ala Gly Leu Arg Leu Thr Ala Leu 
        35                  40                  45              


Ser Pro Glu His Gln Ser Pro Ala Glu Ser Gly Asp Asn Thr Ser Ser 
    50                  55                  60                  


Leu Gln Arg Gly Thr Ser Pro Pro Ala Ala Thr Ser Leu Arg Leu Leu 
65                  70                  75                  80  


Leu Ser Ser Lys Asp Ser Leu Gly Phe Lys Cys His Phe Pro Cys Phe 
                85                  90                  95      


Arg Asp Pro Gly Val Leu Ile Ala 
            100                 


<210>  4912
<211>  2887
<212>  DNA
<213>  Homosapiens

<400>  4912
aaaattttat taaccagcat gtttggtata tttaaagcag tgactgagtg tgtttgagtg     60

agtggctgag tgcagtgtct tttgtttaaa cacactgcct cgtgtctttg tagctgattc    120

agagagtttg aattgtgggg tgggagacta acttcagctc caggctgcag taatgtgttg    180

gtagttacac ttgaggcatt tttttgttgt tgttaattaa ctctatagtc tcaaactatt    240

tttgcaaata tatcattttt cctaattggt tcttgacgtg cagtggactg gctctgtgaa    300

tgattggcag ggtcttagtt ttgcgagagt atttccttct aagaattatt gtgatctgca    360

gaaacagcca tttgattcaa aaatcatgta gaaaaggagt aggagaagca aaacgtttca    420

tttttgggcc ttaaccattt gaaatgtttg gactttaaac ataaagccat ggagtttata    480

aagccaagta accatttgat atggataata atatctactc tagagagagt atatatatgc    540

acattgattt ttaatgctgt taagatactt ttgtaaaact gtaggaacaa gagtaattag    600

accaaattga agcttagggg acagtaaagt ggttgctttc catttagggt aaccatgcat    660

gtggttagtc ctctcctcct gagattcaga accagttgac tgtcccctta ggtgtataag    720

gagaaaagtt gacatgtctg ggacctctga catgtgtaca catgcttgca cacatgcaca    780

cacagtgaat gttttaagtt atacaaacat aagaccttaa gatgcaaaga gccagaatat    840

tctaaagagg tgatgaacag agggggtgga aactgcatca cagatgtttt ccaagggcca    900

gggtggaatc tgagctctag tgtctgactt tgagatgcat tatattttta acacataaat    960

gaggggatcc atatcacatt ctttcttgtg gaccaccaaa ttgaaggctt tcttgtaatt   1020

cacaagcagc agctctccag catctctccg tagcctgggt gaagtcccag aagctggtgt   1080

gcatcatttt ccaaggtggc agagctgctt gctctgcaga tcattccttt gagagaggag   1140

tacaagtgaa gaaacaagga ggcacttcct gtaggagcac tgatgtgcct tgtccacact   1200

cccctctgag ctttactggt aagagagctc cgactgaaca tgctgagcag ttgagcactt   1260

ttccatcagc aacaacagcg aggatggaaa tggaaaggaa ccgaactaaa atgcatttcc   1320

ctttgcaggg cagagagcta agctcttagg aatagtgtta tagaaataag caccctaact   1380

tcaattcctg aaaatgttgg ttaatggaga gaattttgga gtttcactta atattttccc   1440

atcggtcgcc ataaataagt cttcaggcgc tcctagaaga gtcccagccc aaggctcgat   1500

taaggaccac actgcaggtc tgaggctcac tgctctgagt cctgaacacc agagccctgc   1560

agagagtggt gataacacat catctctgca aagaggaacc tctcccccgg ccgccacttc   1620

actcaggctt ctactgagca gcaaggacag cctgggtttc aaatgccact tcccctgctt   1680

tagggatcca ggtgtcctga tagcgtgacc ctgctgaggc aaggtatcaa ctccgagagt   1740

gactgagtca ctgagcgtgg cacatgaaca aacgtcatga caaagattct ctgagtgaag   1800

ttaacaccac gtattttacc tttgcaaaaa acaaactggc accctgagtt ctaactacgg   1860

acggacgata tctttgcctc cacacccaga ttcctggaaa tggctaacgt ttcctttcta   1920

ggggaagggt cgaggaatac tcaagtgcta gcttagcagc tttgttcagt ccagatcaga   1980

gctgttaggt aaaggcctaa ccacctccct gcagtctctt atatctcaag ctttaggaac   2040

ccatttctaa atgtacacta gcggagaatt tatattgtca gccttgatta ccataggaca   2100

ggcagaaagg cgataatttg tatcttttaa tataaaagaa gcttttaact tttccagcct   2160

attataataa ctgagttata ttcactgtgg ctcaaactaa ttggcattgt ggaacatttc   2220

tttaccttca aagttttctc caccaatcat ttcagttcta ttgcagtcct ggtgccatat   2280

gtcccctgca aattgtgaaa gtaattagtg acaaaatagc agcctgctcc ttttcaatgg   2340

cgaaactgtc ggcattagca gttttgggta agctggcggt actataacac gtactggaaa   2400

cctgttcctc atcaccacct accagattct ggaaatgccg tcttctagaa aacgatggcg   2460

tttgtggtgg tcttcttttg aaaggaacag taatttgtgt ggatattgtt aaagtgttta   2520

aagaatattt tgacaattaa gtttacattt tacaattgct ttatttttta ttaaaatagt   2580

tgtatataaa tattacccta tttcactgtt gttcaagtaa atctaaacct tgtagacaag   2640

tgagtcatct gatatgtata gaagctgtga tatatagagt acatttattg tgtaaatgtt   2700

tatgaatata attgttcctg tgtttttata agttggggat attttgttgt tttacggcaa   2760

caaaatttat tgcatttaaa tggtttttat gtaatagaaa tcacgcaaaa tagtgaagga   2820

tttaaaatat gtatatgata catgtaaatg tacaaacttt agaaagaaat aaatccaaca   2880

aatttca                                                             2887


<210>  4913
<211>  104
<212>  PRT
<213>  Homosapiens

<400>  4913

Met Leu Val Asn Gly Glu Asn Phe Gly Val Ser Leu Asn Ile Phe Pro 
1               5                   10                  15      


Ser Val Ala Ile Asn Lys Ser Ser Gly Ala Pro Arg Arg Val Pro Ala 
            20                  25                  30          


Gln Gly Ser Ile Lys Asp His Thr Ala Gly Leu Arg Leu Thr Ala Leu 
        35                  40                  45              


Ser Pro Glu His Gln Ser Pro Ala Glu Ser Gly Asp Asn Thr Ser Ser 
    50                  55                  60                  


Leu Gln Arg Gly Thr Ser Pro Pro Ala Ala Thr Ser Leu Arg Leu Leu 
65                  70                  75                  80  


Leu Ser Ser Lys Asp Ser Leu Gly Phe Lys Cys His Phe Pro Cys Phe 
                85                  90                  95      


Arg Asp Pro Gly Val Leu Ile Ala 
            100                 


<210>  4914
<211>  444
<212>  DNA
<213>  Homosapiens

<400>  4914
atgactgggc accggttggt ccactgcggc tgttccaagc tgcccccaca gcctcacccc     60

aggactccac caggagcaca gggaaggggt ccccgaaagt gggcgaggtc gctgcccgga    120

ggtctcactc tctgcgccgc gccgcgcccc tcgccccatc ccgagcagct accccgaagc    180

tcccaggggc tccgccgagg cgaatcctca cattgcggcg tggtggccga caaaacccgg    240

gaccctgatc ttggcgcctc cacgccaccg cccggaggcc aagacccccg agcgccgcag    300

catagcgtag cccagaccag tcacctcatc ctttttcgcc ctctcaaccc agcttttccc    360

gactccggga agaaccggga agagaaggcg gaggggagcg aagcgccgcc tgataaatac    420

tgtggcccag tcccgccccc ctaa                                           444


<210>  4915
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  4915

Met Thr Gly His Arg Leu Val His Cys Gly Cys Ser Lys Leu Pro Pro 
1               5                   10                  15      


Gln Pro His Pro Arg Thr Pro Pro Gly Ala Gln Gly Arg Gly Pro Arg 
            20                  25                  30          


Lys Trp Ala Arg Ser Leu Pro Gly Gly Leu Thr Leu Cys Ala Ala Pro 
        35                  40                  45              


Arg Pro Ser Pro His Pro Glu Gln Leu Pro Arg Ser Ser Gln Gly Leu 
    50                  55                  60                  


Arg Arg Gly Glu Ser Ser His Cys Gly Val Val Ala Asp Lys Thr Arg 
65                  70                  75                  80  


Asp Pro Asp Leu Gly Ala Ser Thr Pro Pro Pro Gly Gly Gln Asp Pro 
                85                  90                  95      


Arg Ala Pro Gln His Ser Val Ala Gln Thr Ser His Leu Ile Leu Phe 
            100                 105                 110         


Arg Pro Leu Asn Pro Ala Phe Pro Asp Ser Gly Lys Asn Arg Glu Glu 
        115                 120                 125             


Lys Ala Glu Gly Ser Glu Ala Pro Pro Asp Lys Tyr Cys Gly Pro Val 
    130                 135                 140                 


Pro Pro Pro 
145         


<210>  4916
<211>  444
<212>  DNA
<213>  Homosapiens

<400>  4916
atgactgggc accggttggt ccactgcggc tgttccaagc tgcccccaca gcctcacccc     60

aggactccac caggagcaca gggaaggggt ccccgaaagt gggcgaggtc gctgcccgga    120

ggtctcactc tctgcgccgc gccgcgcccc tcgccccatc ccgagcagct accccgaagc    180

tcccaggggc tccgccgagg cgaatcctca cattgcggcg tggtggccga caaaacccgg    240

gaccctgatc ttggcgcctc cacgccaccg cccggaggcc aagacccccg agcgccgcag    300

catagcgtag cccagaccag tcacctcatc ctttttcgcc ctctcaaccc agcttttccc    360

gactccggga agaaccggga agagaaggcg gaggggagcg aagcgccgcc tgataaatac    420

tgtggcccag tcccgccccc ctaa                                           444


<210>  4917
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  4917

Met Thr Gly His Arg Leu Val His Cys Gly Cys Ser Lys Leu Pro Pro 
1               5                   10                  15      


Gln Pro His Pro Arg Thr Pro Pro Gly Ala Gln Gly Arg Gly Pro Arg 
            20                  25                  30          


Lys Trp Ala Arg Ser Leu Pro Gly Gly Leu Thr Leu Cys Ala Ala Pro 
        35                  40                  45              


Arg Pro Ser Pro His Pro Glu Gln Leu Pro Arg Ser Ser Gln Gly Leu 
    50                  55                  60                  


Arg Arg Gly Glu Ser Ser His Cys Gly Val Val Ala Asp Lys Thr Arg 
65                  70                  75                  80  


Asp Pro Asp Leu Gly Ala Ser Thr Pro Pro Pro Gly Gly Gln Asp Pro 
                85                  90                  95      


Arg Ala Pro Gln His Ser Val Ala Gln Thr Ser His Leu Ile Leu Phe 
            100                 105                 110         


Arg Pro Leu Asn Pro Ala Phe Pro Asp Ser Gly Lys Asn Arg Glu Glu 
        115                 120                 125             


Lys Ala Glu Gly Ser Glu Ala Pro Pro Asp Lys Tyr Cys Gly Pro Val 
    130                 135                 140                 


Pro Pro Pro 
145         


<210>  4918
<211>  645
<212>  DNA
<213>  Homosapiens

<400>  4918
atggagagct cactaggatc acctgtgcta gaggaaacgc tgaattcatt ttctatacat     60

tatgcagaag atgacatcac tcttgccaaa gccatcagca gagaactgtg tgcgtattat    120

ctgaaagaag attatgcaga tccaaacctg actgccaagt ggaaaagaga cagttacaag    180

gctttgtgct gcctgtggtg tgttcagact caggatacca actttggaac caactgcatc    240

tgccaggctt ctgccttttt gctctcagga attaccgctg ctgaactgga agtagagatt    300

gtccctggcc cttcctcatc aacattatct cagaagtcct tccctcttga aaactttcca    360

tgccagcttc atgctgccaa gactgaatta actaccggac cttcaggata ccctgggacc    420

aactatccct ctgggggcat tacccaggct cttaaaatgg aggcagctaa ggcccaggga    480

gaaattgagt gcagcaccgg tgggccagca caggtggaag acccggcaca ccctccgcag    540

ctgctggcct gggtgctaag cccgttagag cccgcggcca gcggggctgg tcggctgctc    600

cgaaaaaaca gccaattcag tgaactggtt gagctgccca cctaa                    645


<210>  4919
<211>  214
<212>  PRT
<213>  Homosapiens

<400>  4919

Met Glu Ser Ser Leu Gly Ser Pro Val Leu Glu Glu Thr Leu Asn Ser 
1               5                   10                  15      


Phe Ser Ile His Tyr Ala Glu Asp Asp Ile Thr Leu Ala Lys Ala Ile 
            20                  25                  30          


Ser Arg Glu Leu Cys Ala Tyr Tyr Leu Lys Glu Asp Tyr Ala Asp Pro 
        35                  40                  45              


Asn Leu Thr Ala Lys Trp Lys Arg Asp Ser Tyr Lys Ala Leu Cys Cys 
    50                  55                  60                  


Leu Trp Cys Val Gln Thr Gln Asp Thr Asn Phe Gly Thr Asn Cys Ile 
65                  70                  75                  80  


Cys Gln Ala Ser Ala Phe Leu Leu Ser Gly Ile Thr Ala Ala Glu Leu 
                85                  90                  95      


Glu Val Glu Ile Val Pro Gly Pro Ser Ser Ser Thr Leu Ser Gln Lys 
            100                 105                 110         


Ser Phe Pro Leu Glu Asn Phe Pro Cys Gln Leu His Ala Ala Lys Thr 
        115                 120                 125             


Glu Leu Thr Thr Gly Pro Ser Gly Tyr Pro Gly Thr Asn Tyr Pro Ser 
    130                 135                 140                 


Gly Gly Ile Thr Gln Ala Leu Lys Met Glu Ala Ala Lys Ala Gln Gly 
145                 150                 155                 160 


Glu Ile Glu Cys Ser Thr Gly Gly Pro Ala Gln Val Glu Asp Pro Ala 
                165                 170                 175     


His Pro Pro Gln Leu Leu Ala Trp Val Leu Ser Pro Leu Glu Pro Ala 
            180                 185                 190         


Ala Ser Gly Ala Gly Arg Leu Leu Arg Lys Asn Ser Gln Phe Ser Glu 
        195                 200                 205             


Leu Val Glu Leu Pro Thr 
    210                 


<210>  4920
<211>  1907
<212>  DNA
<213>  Homosapiens

<400>  4920
ctgtagtgtt tgccaatgtt ggagccgtct gcaaagtgtc cccggcaaga aggtaaatac     60

cctcatcggg ggcgtccggg agaccccgac ttccgcgccg ccggcgaaga aggcagaggg    120

cgctggggag ccctgcagtt ccgcagcacg gggaacccgg agaaaagcag cccccttcgc    180

ggcctcccct cccccgcgcc ttccctccca catcgggctc tcggggcagc agcggggagg    240

ggagaccggc gggggaggga ggacagggag gcgaaggaat tggggtgggg ggtgcgtgtg    300

tggtggaggg ggtgggacga cacaggtgtc ctgaggggag gagccgggag gaaggcgagg    360

aggccgggcc aagtgggggt gcggaggtcg gggagacagg aacgcggctg cgggcgcggg    420

aggctggggt tctagggggc cggggtggta gcggccggaa gagaggacgg cgagtgcagc    480

cacggtgtgg ctgcgaggga gagggagcgc ctagagtagg gcaggggagg gcggcccggg    540

gagggtctgc gggaaatggg cctgggggcg ctggaggcgg agcggcgggg ccggggcgcg    600

ccggagggtg gcggcggcag ctatttctgt agaatgggct agtggtaaag acgtaacttg    660

ccgaaatggg gagggtaggt ggggccgagg ggacaaaata tatcctatga caggcaagtt    720

ctgctgtggc tgttacgaac tcctaccgtg atggctcggc ttaaaggggt agttggcggt    780

agtgaccttg ccggggtgaa gggagttggg cgaggagaca aagctcagtt acggaatccg    840

ctgtgtgaga gcaggaactc tagtctcttc ggggtcgagc cgggggctgt ggcttggggg    900

ctgggggtgc tccgcagagg ccattgagaa gcacgccact ctgggattct tagggaggcg    960

gtgggggtaa tggccgtggg attctggaag tctttggaaa tgtgtgtaga attttgcatt   1020

tgtgaataat tttctttggt aagggtccat atttgctgtg atgtcccctt acccccatcc   1080

ccactccaaa gggttaagaa ctgcttgagc agatagagag ggaccattca attagggtag   1140

acctgggaat ttaccaaagg attttaaagt gggtggatcc tgcagaaaga aaggctagag   1200

atgatccttt aaagatattt tactgttaat tgaaaacgtt ttttatttaa tgtttgcttt   1260

cacaattttg gtgaactttt gctgagcatt acttggcttc tgatgcatcc tgtgtttcag   1320

accagcatcg tgaatacttg aaatcaaaat tgtgatggac aggcagggtg atagtaacct   1380

tggaggagaa aagatttcaa catttctcca ggatatttct tccccgtcct tgctttcttt   1440

agatgattca agtacactgt tgtgaactca gctgcggtgg aaaaatctta tttaataaaa   1500

ctaccaaaac caagacttac tctccatctc tgttttgtag tatggccaga ttttcattgt   1560

tcagtttgta tcttactgca aacaagagat atcacataac actttaattg tagattgctg   1620

cattttgcag caggcctgta ttaaatttgc gaagcagtta tgccaaacta tctggtgtgt   1680

ttgtgttttc ctgctatggt ttcaagtcaa gtcactattg ccatatttta ttatatggta   1740

ggctagtctg aaatttattc ctaagtgatg ataagttggt aggatatggt acatacttgc   1800

tcacaaatta ctgcattttt ccccataaaa accagtgttt tgtatttgta agaatgttgc   1860

tgtgtaatcc aagtatgtat tgttaatttc aaataaaatg ctgtgta                 1907


<210>  4921
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  4921

Met Leu Glu Pro Ser Ala Lys Cys Pro Arg Gln Glu Gly Lys Tyr Pro 
1               5                   10                  15      


His Arg Gly Arg Pro Gly Asp Pro Asp Phe Arg Ala Ala Gly Glu Glu 
            20                  25                  30          


Gly Arg Gly Arg Trp Gly Ala Leu Gln Phe Arg Ser Thr Gly Asn Pro 
        35                  40                  45              


Glu Lys Ser Ser Pro Leu Arg Gly Leu Pro Ser Pro Ala Pro Ser Leu 
    50                  55                  60                  


Pro His Arg Ala Leu Gly Ala Ala Ala Gly Arg Gly Asp Arg Arg Gly 
65                  70                  75                  80  


Arg Glu Asp Arg Glu Ala Lys Glu Leu Gly Trp Gly Val Arg Val Trp 
                85                  90                  95      


Trp Arg Gly Trp Asp Asp Thr Gly Val Leu Arg Gly Gly Ala Gly Arg 
            100                 105                 110         


Lys Ala Arg Arg Pro Gly Gln Val Gly Val Arg Arg Ser Gly Arg Gln 
        115                 120                 125             


Glu Arg Gly Cys Gly Arg Gly Arg Leu Gly Phe 
    130                 135                 


<210>  4922
<211>  1907
<212>  DNA
<213>  Homosapiens

<400>  4922
ctgtagtgtt tgccaatgtt ggagccgtct gcaaagtgtc cccggcaaga aggtaaatac     60

cctcatcggg ggcgtccggg agaccccgac ttccgcgccg ccggcgaaga aggcagaggg    120

cgctggggag ccctgcagtt ccgcagcacg gggaacccgg agaaaagcag cccccttcgc    180

ggcctcccct cccccgcgcc ttccctccca catcgggctc tcggggcagc agcggggagg    240

ggagaccggc gggggaggga ggacagggag gcgaaggaat tggggtgggg ggtgcgtgtg    300

tggtggaggg ggtgggacga cacaggtgtc ctgaggggag gagccgggag gaaggcgagg    360

aggccgggcc aagtgggggt gcggaggtcg gggagacagg aacgcggctg cgggcgcggg    420

aggctggggt tctagggggc cggggtggta gcggccggaa gagaggacgg cgagtgcagc    480

cacggtgtgg ctgcgaggga gagggagcgc ctagagtagg gcaggggagg gcggcccggg    540

gagggtctgc gggaaatggg cctgggggcg ctggaggcgg agcggcgggg ccggggcgcg    600

ccggagggtg gcggcggcag ctatttctgt agaatgggct agtggtaaag acgtaacttg    660

ccgaaatggg gagggtaggt ggggccgagg ggacaaaata tatcctatga caggcaagtt    720

ctgctgtggc tgttacgaac tcctaccgtg atggctcggc ttaaaggggt agttggcggt    780

agtgaccttg ccggggtgaa gggagttggg cgaggagaca aagctcagtt acggaatccg    840

ctgtgtgaga gcaggaactc tagtctcttc ggggtcgagc cgggggctgt ggcttggggg    900

ctgggggtgc tccgcagagg ccattgagaa gcacgccact ctgggattct tagggaggcg    960

gtgggggtaa tggccgtggg attctggaag tctttggaaa tgtgtgtaga attttgcatt   1020

tgtgaataat tttctttggt aagggtccat atttgctgtg atgtcccctt acccccatcc   1080

ccactccaaa gggttaagaa ctgcttgagc agatagagag ggaccattca attagggtag   1140

acctgggaat ttaccaaagg attttaaagt gggtggatcc tgcagaaaga aaggctagag   1200

atgatccttt aaagatattt tactgttaat tgaaaacgtt ttttatttaa tgtttgcttt   1260

cacaattttg gtgaactttt gctgagcatt acttggcttc tgatgcatcc tgtgtttcag   1320

accagcatcg tgaatacttg aaatcaaaat tgtgatggac aggcagggtg atagtaacct   1380

tggaggagaa aagatttcaa catttctcca ggatatttct tccccgtcct tgctttcttt   1440

agatgattca agtacactgt tgtgaactga gctgcggtgg aaaaatctta tttaataaaa   1500

ctaccaaaac caagacttac tctccatctc tgttttgtag tatggccaga ttttcattgt   1560

tcagtttgta tcttactgca aacaagagat atcacataac actttaattg tagattgctg   1620

cattttgcag caggcctata ttaaatttgc gaagcagtta tgccaaacta tctggtgtgt   1680

ttgtgttttc ctgctatggt ttcaagtcaa gtcactattg ccatatttta ttatatggta   1740

ggctagtctg aaatttattc ctaagtgatg ataagttggt aggatatggt acatacttgc   1800

tcacaaatta ctgcattttt ccccataaaa accagtgttt tgtatttgta agaatgttgc   1860

tgtgtaatcc aagtatgtat tgttaatttc aaataaaatg ctgtgta                 1907


<210>  4923
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  4923

Met Leu Glu Pro Ser Ala Lys Cys Pro Arg Gln Glu Gly Lys Tyr Pro 
1               5                   10                  15      


His Arg Gly Arg Pro Gly Asp Pro Asp Phe Arg Ala Ala Gly Glu Glu 
            20                  25                  30          


Gly Arg Gly Arg Trp Gly Ala Leu Gln Phe Arg Ser Thr Gly Asn Pro 
        35                  40                  45              


Glu Lys Ser Ser Pro Leu Arg Gly Leu Pro Ser Pro Ala Pro Ser Leu 
    50                  55                  60                  


Pro His Arg Ala Leu Gly Ala Ala Ala Gly Arg Gly Asp Arg Arg Gly 
65                  70                  75                  80  


Arg Glu Asp Arg Glu Ala Lys Glu Leu Gly Trp Gly Val Arg Val Trp 
                85                  90                  95      


Trp Arg Gly Trp Asp Asp Thr Gly Val Leu Arg Gly Gly Ala Gly Arg 
            100                 105                 110         


Lys Ala Arg Arg Pro Gly Gln Val Gly Val Arg Arg Ser Gly Arg Gln 
        115                 120                 125             


Glu Arg Gly Cys Gly Arg Gly Arg Leu Gly Phe 
    130                 135                 


<210>  4924
<211>  4289
<212>  DNA
<213>  Homosapiens

<400>  4924
attaactaaa caagtcacag tctttatttt taatttctac agtcacctcg tgagacaggt     60

attagaactc cggagtggca tcaaaatgag ggaaaggcct cagggccagc gcctttgcgt    120

cctggaccgg cgtacagacg ggagaaaggc cgaccaatcc gagagcaggc tgaggcctgg    180

tcccgcccct gggggcagag cctcgcctct tttccgcctc accctttggg agtaggggtg    240

tgcggctggc ttgtcccgcc cctgcccctg agtgacagaa ccgtggacag caacatttcc    300

cacaggacac gaagtttgtc ggcccttgcc ttggcagagc tgaggtgtgt gtccggcgag    360

tgcgagggga ttggggagac cctgcccggg aagctcgggg tccgggaatg aaagcgggcg    420

cacctcttta gcgagcccta aagcgtttgg gagacgatcg ttccgtccct gggagcggca    480

cttggtgggg ctgggcggag ggaggctctg caagagaaac ccggagtccg ggaaacccag    540

tagtttctgg aggctgctca cattccttgg cttatggcct ccttcttcca acgtcaaagc    600

cagcaacatt gcagcaatct gacttatttt gttgtcatgt ctcctgacca catctggaag    660

ggttatctac ttttgaagac acatccagat aattcaggac aatctgtcca ttttgaggtt    720

cttcattgaa tcatgtctgc aaagtccctt ctgcaatcta agtaagaaaa atcaccaaga    780

atattatttt tggtatttgg aattgaattt gccaggaatg caagcactgc tacctaacta    840

aagaccttgg ctttggaaac atcttacccc ttggcagctc tccagagttt agacttggca    900

gcatcaaaga cacaacgcaa gcaggcattt tggagatcaa agatgggtag aaaagatgct    960

gctactataa aacttcctgt tgatcagtac agaaaacaaa ttggtaaaca ggattataaa   1020

aaaactaaac ctattttacg agcaaccaaa ttaaaagcag aagcaaagaa aacagcaata   1080

ggcataaagg aagttggcct tgtacttgca gctatattgg cactactact ggctttctat   1140

gctttctttt atctcagact caccacggat gttgaccctg atctggacca agatgaagat   1200

tagctaagca acaatcaatg catgaaagag aaataacttt acgaaagcac cttttgggac   1260

caaaactttc aatactgaaa ctgtaacatc tttaattctt tctgctaata ttttcagttt   1320

gcagacatat gatttttgat agttgcatag gatgtcagga aaagaacctt acctagcaat   1380

gcagtatagt atgtgctact ggatactttt atatatcttt ctgctttgac agccacccta   1440

tacatggtac atttagatga aatgggaacc agatcctaaa tttttcaaat gtcattgcca   1500

atttatgtgt ataattccat cacttcctga tgagtaagtc tatttttgtt ctatatacat   1560

cataagttag tatatattct tatttacaga aacatgctca aatcacattc agaaagaaca   1620

aaaagtcatg ggaaattttt tattttacaa caaagccctg ctttctttct ggacgtattt   1680

tacatcatta gagagactat ctgcacatac atctaccata atctttttcc ttctttgcca   1740

actgttcagt gcacatgtgc tgcatcagaa atggcacctg gatgacagaa gctcaaagag   1800

tcacatatgt ctctaaaata gagttctttt cctcttgggc tgtctgaact ggtgtaaata   1860

gaagctcagt tgatcttggt tttaattaac ttattactct attaatataa ccttggaatt   1920

ctattctaat tatgttgttc tggctgcttg tagtatcagt tcgcccctct tgttagggag   1980

atatgtaaca atctgtcatt taattgagca gtctttttca cataacagta atagcaaaaa   2040

tcctacctac tcagaatcat cttcttaggt tgtctcctaa atctgaacaa tacagttgtt   2100

ttataaaatt acattttgtc tcttgagatt taatcaatta gaactcttta gggagaaaat   2160

aaataataga agaaaatata tgcctcatat ttcatatgta attatctgtt gatataattt   2220

ttcaatgtat tttgtatttg tgggagcata atgacctgta cattcaatat ttttactggt   2280

aattcaattt ttaaatatgt ttttacaatg cttgaacaca taaaccttag aaaactggaa   2340

aatacgtgtc cacagaaaga gttattagct actaccttat gtaaagatgc atagaaaatg   2400

aaattgttgg aaacatgtgc acaaagtgtt ttatattata tacattgtat ttatgaagaa   2460

taaataaaat attaagattg ttttcctgct agccaagaga agaaatcctt gggaaatatc   2520

taaggagtat atggggcttt ataagcactg tttctaaaag atattctctg gtacttttgc   2580

aaaaagtcga ctgtgactgt gtagcattat gttctgtaga atttttttca agtagcataa   2640

tttatttcat tggtgtgaaa acagccaaag gttccaatat cctcacaaat catttatgcc   2700

aaacatctga gggcaaaatt tagccggtgt tatttactag attcttccct ttgaactcac   2760

agactcaaga gacagaccaa gagttcttat atactcacca cagcggacca atccaagtgg   2820

catttttagg aaaggttgca gcatttaatg ccatgtggta tgtctgttcg tcaagtgggt   2880

ggcaagggaa tatccaagct ggcattttgg atatgatggg ccttttactt tcctgagtga   2940

catgccacat gtcaagaaat actgctcccc acccccccac tcccatcaca tttacgtgaa   3000

caattttcat ttagttattt cccgttccat atggtgttaa aacagtcgta ttaaataaag   3060

attatttcta gttttcagtg gtaatttaaa tgagaggata tgtaataatt gcttattaga   3120

tacttatcca aatgaaatat aacagagttt acagtactta aaatggctgg ttatggtctt   3180

ggaaatgttt gaaaattcat tatcctgaaa aaaactttac cattctgttt tacccttgag   3240

gtattttttg gggaaaaatg tttttgataa ctattaatct aaatatagta taattatagg   3300

caaatttcac tgcctagttt tattgatatc ctgagtctac agctagtcca ttcgtatgac   3360

tgattgattt atgatagctc cagagaacca taaatttcaa aggctaaact ctctgatttt   3420

agtaaatagt aggtaaagtg acacaatata tgtttacaca acactgtttt catgaaatgc   3480

aaactttgca aaactcacat taactgggaa gcagccaacc ctctgtagag aaatcccaga   3540

ttgggagtct ggtttgaatc tttgaagaca gaaaggtgat atccggcctg ctgttttaaa   3600

gggaccacac ttttgaatac ctactggtgt ttggcagaaa tctgagactg gcaccagaca   3660

caaattttag acatgggtat cttccctcca gtaattcact gctcagagta atttagaaga   3720

caaaaacaga aaaaattgta atgatttttt aagtgttaga atatgtttgt taacatactc   3780

tgcaaaataa atttcaacta atgcaataga cttaaaatat agcctatgga atactgtgat   3840

tgaagtttga aggcttgctg gttcttattt tgcatgcaag tttagacagg gtaaagaatg   3900

tataaattta tttgagatga gatacagtat tgtaaaaata taacctcatc tagaattgct   3960

tttaaaacaa gcaaaagcct attttagtac aaatgtaggg tgggtagttg ttttaaggta   4020

gcaaaatact tcaagatttt ctatcttttt aatttttcat gaagacagaa gaaatacttt   4080

caccccaacc aatgactgta agatcttgag agtatgttct tactcatttc tgtaattgca   4140

gtagtgtagt catctgcata taaatttaat aaatgcatgt taaaatttaa gttgatgcct   4200

tttagtcctc tcagagtctg tcacagtttc tttgtgtaaa tgataaaaaa gtttgaattt   4260

aatcaataaa acttaaaaat cacaatatc                                     4289


<210>  4925
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  4925

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  4926
<211>  3676
<212>  DNA
<213>  Homosapiens

<400>  4926
gtggacagca acatttccca caggacacga agtttgtcgg cccttgcctt ggcagagctg     60

agtaagaaaa atcaccaaga atattatttt tggtatttgg aattgaattt gccaggaatg    120

caagcactgc tacctaacta aagaccttgg ctttggaaac atcttacccc ttggcagctc    180

tccagagttt agacttggca gcatcaaaga cacaacgcaa gcaatatgaa acagaaaaac    240

aagttggttg gatagctgtc ctccatgcag tcattcatga tccaggctgt catcatcttc    300

atcactcatg ttcagagtta ccctagaggt catctccatt tcatccagat aaatgagtat    360

gcaaggaacg tttttatagg cattttggag atcaaagatg ggtagaaaag atgctgctac    420

tataaaactt cctgttgatc agtacagaaa acaaattggt aaacaggatt ataaaaaaac    480

taaacctatt ttacgagcaa ccaaattaaa agcagaagca aagaaaacag caataggcat    540

aaagactcac cacggatgtt gaccctgatc tggaccaaga tgaagattag ctaagcaaca    600

atcaatgcat gaaagagaaa taactttacg aaagcacctt ttgggaccaa aactttcaat    660

actgaaactg taacatcttt aattctttct gctaatattt tcagtttgca gacatatgat    720

ttttgatagt tgcataggat gtcaggaaaa gaaccttacc tagcaatgca gtatagtatg    780

tgctactgga tacttttata tatctttctg ctttgacagc caccctatac atggtacatt    840

tagatgaaat gggaaccaga tcctaaattt ttcaaatgtc attgccaatt tatgtgtata    900

attccatcac ttcctgatga gtaagtctat ttttgttcta tatacatcat aagttagtat    960

atattcttat ttacagaaac atgctcaaat cacattcaga aagaacaaaa agtcatggga   1020

aattttttat tttacaacaa agccctgctt tctttctgga cgtattttac atcattagag   1080

agactatctg cacatacatc taccataatc tttttccttc tttgccaact gttcagtgca   1140

catgtgctgc atcagaaatg gcacctggat gacagaagct caaagagtca catatgtctc   1200

taaaatagag ttcttttcct cttgggctgt ctgaactggt gtaaatagaa gctcagttga   1260

tcttggtttt aattaactta ttactctatt aatataacct tggaattcta ttctaattat   1320

gttgttctgg ctgcttgtag tatcagttcg cccctcttgt tagggagata tgtaacaatc   1380

tgtcatttaa ttgagcagtc tttttcacat aacagtaata gcaaaaatcc tacctactca   1440

gaatcatctt cttaggttgt ctcctaaatc tgaacaatac agttgtttta taaaattaca   1500

ttttgtctct tgagatttaa tcaattagaa ctctttaggg agaaaataaa taatagaaga   1560

aaatatatgc ctcatatttc atatgtaatt atctgttgat ataatttttc aatgtatttt   1620

gtatttgtgg gagcataatg acctgtacat tcaatatttt tactggtaat tcaattttta   1680

aatatgtttt tacaatgctt gaacacataa accttagaaa actggaaaat acgtgtccac   1740

agaaagagtt attagctact accttatgta aagatgcata gaaaatgaaa ttgttggaaa   1800

catgtgcaca aagtgtttta tattatatac attgtattta tgaagaataa ataaaatatt   1860

aagattgttt tcctgctagc caagagaaga aatccttggg aaatatctaa ggagtatatg   1920

gggctttata agcactgttt ctaaaagata ttctctggta cttttgcaaa aagtcgactg   1980

tgactgtgta gcattatgtt ctgtagaatt tttttcaagt agcataattt atttcattgg   2040

tgtgaaaaca gccaaaggtt ccaatatcct cacaaatcat ttatgccaaa catctgaggg   2100

caaaatttag ccggtgttat ttactagatt cttccctttg aactcacaga ctcaagagac   2160

agaccaagag ttcttatata ctcaccacag cggaccaatc caagtggcat ttttaggaaa   2220

ggttgcagca tttaatgcca tgtggtatgt ctgttcgtca agtgggtggc aagggaatat   2280

ccaagctggc attttggata tgatgggcct tttactttcc tgagtgacat gccacatgtc   2340

aagaaatact gctccccacc cccccactcc catcacattt acgtgaacaa ttttcattta   2400

gttatttccc gttccatatg gtgttaaaac agtcgtatta aataaagatt atttctagtt   2460

ttcagtggta atttaaatga gaggatatgt aataattgct tattagatac ttatccaaat   2520

gaaatataac agagtttaca gtacttaaaa tggctggtta tggtcttgga aatgtttgaa   2580

aattcattat cctgaaaaaa actttaccat tctgttttac ccttgaggta ttttttgggg   2640

aaaaatgttt ttgataacta ttaatctaaa tatagtataa ttataggcaa atttcactgc   2700

ctagttttat tgatatcctg agtctacagc tagtccattc gtatgactga ttgatttatg   2760

atagctccag agaaccataa atttcaaagg ctaaactctc tgattttagt aaatagtagg   2820

taaagtgaca caatatatgt ttacacaaca ctgttttcat gaaatgcaaa ctttgcaaaa   2880

ctcacattaa ctgggaagca gccaaccctc tgtagagaaa tcccagattg ggagtctggt   2940

ttgaatcttt gaagacagaa aggtgatatc cggcctgctg ttttaaaggg accacacttt   3000

tgaataccta ctggtgtttg gcagaaatct gagactggca ccagacacaa attttagaca   3060

tgggtatctt ccctccagta attcactgct cagagtaatt tagaagacaa aaacagaaaa   3120

aattgtaatg attttttaag tgttagaata tgtttgttaa catactctgc aaaataaatt   3180

tcaactaatg caatagactt aaaatatagc ctatggaata ctgtgattga agtttgaagg   3240

cttgctggtt cttattttgc atgcaagttt agacagggta aagaatgtat aaatttattt   3300

gagatgagat acagtattgt aaaaatataa cctcatctag aattgctttt aaaacaagca   3360

aaagcctatt ttagtacaaa tgtagggtgg gtagttgttt taaggtagca aaatacttca   3420

agattttcta tctttttaat ttttcatgaa gacagaagaa atactttcac cccaaccaat   3480

gactgtaaga tcttgagagt atgttcttac tcatttctgt aattgcagta gtgtagtcat   3540

ctgcatataa atttaataaa tgcatgttaa aatttaagtt gatgcctttt agtcctctca   3600

gagtctgtca cagtttcttt gtgtaaatga taaaaaagtt tgaatttaat caataaaact   3660

taaaaatcac aatatc                                                   3676


<210>  4927
<211>  54
<212>  PRT
<213>  Homosapiens

<400>  4927

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Thr His His Gly Cys 
    50                  


<210>  4928
<211>  3556
<212>  DNA
<213>  Homosapiens

<400>  4928
ggcttgtccc gcccctgccc ctgagtgaca gaaccgtgga cagcaacatt tcccacagga     60

cacgaagttt gtcggccctt gccttggcag agctgagtaa gaaaaatcac caagaatatt    120

atttttggta tttggaattg aatttgccag gaatgcaagc actgctacct aactaaagac    180

cttggctttg gaaacatctt accccttggc agctctccag agtttagact tggcagcatc    240

aaagacacaa cgcaagcagg cattttggag atcaaagatg ggtagaaaag atgctgctac    300

tataaaactt cctgttgatc agtacagaaa acaaattggt aaacaggatt ataaaaaaac    360

taaacctatt ttacgagcaa ccaaattaaa agcagaagca aagaaaacag caataggcat    420

aaagactcac cacggatgtt gaccctgatc tggaccaaga tgaagattag ctaagcaaca    480

atcaatgcat gaaagagaaa taactttacg aaagcacctt ttgggaccaa aactttcaat    540

actgaaactg taacatcttt aattctttct gctaatattt tcagtttgca gacatatgat    600

ttttgatagt tgcataggat gtcaggaaaa gaaccttacc tagcaatgca gtatagtatg    660

tgctactgga tacttttata tatctttctg ctttgacagc caccctatac atggtacatt    720

tagatgaaat gggaaccaga tcctaaattt ttcaaatgtc attgccaatt tatgtgtata    780

attccatcac ttcctgatga gtaagtctat ttttgttcta tatacatcat aagttagtat    840

atattcttat ttacagaaac atgctcaaat cacattcaga aagaacaaaa agtcatggga    900

aattttttat tttacaacaa agccctgctt tctttctgga cgtattttac atcattagag    960

agactatctg cacatacatc taccataatc tttttccttc tttgccaact gttcagtgca   1020

catgtgctgc atcagaaatg gcacctggat gacagaagct caaagagtca catatgtctc   1080

taaaatagag ttcttttcct cttgggctgt ctgaactggt gtaaatagaa gctcagttga   1140

tcttggtttt aattaactta ttactctatt aatataacct tggaattcta ttctaattat   1200

gttgttctgg ctgcttgtag tatcagttcg cccctcttgt tagggagata tgtaacaatc   1260

tgtcatttaa ttgagcagtc tttttcacat aacagtaata gcaaaaatcc tacctactca   1320

gaatcatctt cttaggttgt ctcctaaatc tgaacaatac agttgtttta taaaattaca   1380

ttttgtctct tgagatttaa tcaattagaa ctctttaggg agaaaataaa taatagaaga   1440

aaatatatgc ctcatatttc atatgtaatt atctgttgat ataatttttc aatgtatttt   1500

gtatttgtgg gagcataatg acctgtacat tcaatatttt tactggtaat tcaattttta   1560

aatatgtttt tacaatgctt gaacacataa accttagaaa actggaaaat acgtgtccac   1620

agaaagagtt attagctact accttatgta aagatgcata gaaaatgaaa ttgttggaaa   1680

catgtgcaca aagtgtttta tattatatac attgtattta tgaagaataa ataaaatatt   1740

aagattgttt tcctgctagc caagagaaga aatccttggg aaatatctaa ggagtatatg   1800

gggctttata agcactgttt ctaaaagata ttctctggta cttttgcaaa aagtcgactg   1860

tgactgtgta gcattatgtt ctgtagaatt tttttcaagt agcataattt atttcattgg   1920

tgtgaaaaca gccaaaggtt ccaatatcct cacaaatcat ttatgccaaa catctgaggg   1980

caaaatttag ccggtgttat ttactagatt cttccctttg aactcacaga ctcaagagac   2040

agaccaagag ttcttatata ctcaccacag cggaccaatc caagtggcat ttttaggaaa   2100

ggttgcagca tttaatgcca tgtggtatgt ctgttcgtca agtgggtggc aagggaatat   2160

ccaagctggc attttggata tgatgggcct tttactttcc tgagtgacat gccacatgtc   2220

aagaaatact gctccccacc cccccactcc catcacattt acgtgaacaa ttttcattta   2280

gttatttccc gttccatatg gtgttaaaac agtcgtatta aataaagatt atttctagtt   2340

ttcagtggta atttaaatga gaggatatgt aataattgct tattagatac ttatccaaat   2400

gaaatataac agagtttaca gtacttaaaa tggctggtta tggtcttgga aatgtttgaa   2460

aattcattat cctgaaaaaa actttaccat tctgttttac ccttgaggta ttttttgggg   2520

aaaaatgttt ttgataacta ttaatctaaa tatagtataa ttataggcaa atttcactgc   2580

ctagttttat tgatatcctg agtctacagc tagtccattc gtatgactga ttgatttatg   2640

atagctccag agaaccataa atttcaaagg ctaaactctc tgattttagt aaatagtagg   2700

taaagtgaca caatatatgt ttacacaaca ctgttttcat gaaatgcaaa ctttgcaaaa   2760

ctcacattaa ctgggaagca gccaaccctc tgtagagaaa tcccagattg ggagtctggt   2820

ttgaatcttt gaagacagaa aggtgatatc cggcctgctg ttttaaaggg accacacttt   2880

tgaataccta ctggtgtttg gcagaaatct gagactggca ccagacacaa attttagaca   2940

tgggtatctt ccctccagta attcactgct cagagtaatt tagaagacaa aaacagaaaa   3000

aattgtaatg attttttaag tgttagaata tgtttgttaa catactctgc aaaataaatt   3060

tcaactaatg caatagactt aaaatatagc ctatggaata ctgtgattga agtttgaagg   3120

cttgctggtt cttattttgc atgcaagttt agacagggta aagaatgtat aaatttattt   3180

gagatgagat acagtattgt aaaaatataa cctcatctag aattgctttt aaaacaagca   3240

aaagcctatt ttagtacaaa tgtagggtgg gtagttgttt taaggtagca aaatacttca   3300

agattttcta tctttttaat ttttcatgaa gacagaagaa atactttcac cccaaccaat   3360

gactgtaaga tcttgagagt atgttcttac tcatttctgt aattgcagta gtgtagtcat   3420

ctgcatataa atttaataaa tgcatgttaa aatttaagtt gatgcctttt agtcctctca   3480

gagtctgtca cagtttcttt gtgtaaatga taaaaaagtt tgaatttaat caataaaact   3540

taaaaatcac aatatc                                                   3556


<210>  4929
<211>  54
<212>  PRT
<213>  Homosapiens

<400>  4929

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Thr His His Gly Cys 
    50                  


<210>  4930
<211>  3408
<212>  DNA
<213>  Homosapiens

<400>  4930
aggggtgtgc ggctggcttg tcccgcccct gcccctgagt gacagaaccg tggacagcaa     60

catttcccac aggacacgaa gtttgtcggc ccttgccttg gcagagctga ggcattttgg    120

agatcaaaga tgggtagaaa agatgctgct actataaaac ttcctgttga tcagtacaga    180

aaacaaattg gtaaacagga ttataaaaaa actaaaccta ttttacgagc aaccaaatta    240

aaagcagaag caaagaaaac agcaataggc ataaagactc accacggatg ttgaccctga    300

tctggaccaa gatgaagatt agctaagcaa caatcaatgc atgaaagaga aataacttta    360

cgaaagcacc ttttgggacc aaaactttca atactgaaac tgtaacatct ttaattcttt    420

ctgctaatat tttcagtttg cagacatatg atttttgata gttgcatagg atgtcaggaa    480

aagaacctta cctagcaatg cagtatagta tgtgctactg gatactttta tatatctttc    540

tgctttgaca gccaccctat acatggtaca tttagatgaa atgggaacca gatcctaaat    600

ttttcaaatg tcattgccaa tttatgtgta taattccatc acttcctgat gagtaagtct    660

atttttgttc tatatacatc ataagttagt atatattctt atttacagaa acatgctcaa    720

atcacattca gaaagaacaa aaagtcatgg gaaatttttt attttacaac aaagccctgc    780

tttctttctg gacgtatttt acatcattag agagactatc tgcacataca tctaccataa    840

tctttttcct tctttgccaa ctgttcagtg cacatgtgct gcatcagaaa tggcacctgg    900

atgacagaag ctcaaagagt cacatatgtc tctaaaatag agttcttttc ctcttgggct    960

gtctgaactg gtgtaaatag aagctcagtt gatcttggtt ttaattaact tattactcta   1020

ttaatataac cttggaattc tattctaatt atgttgttct ggctgcttgt agtatcagtt   1080

cgcccctctt gttagggaga tatgtaacaa tctgtcattt aattgagcag tctttttcac   1140

ataacagtaa tagcaaaaat cctacctact cagaatcatc ttcttaggtt gtctcctaaa   1200

tctgaacaat acagttgttt tataaaatta cattttgtct cttgagattt aatcaattag   1260

aactctttag ggagaaaata aataatagaa gaaaatatat gcctcatatt tcatatgtaa   1320

ttatctgttg atataatttt tcaatgtatt ttgtatttgt gggagcataa tgacctgtac   1380

attcaatatt tttactggta attcaatttt taaatatgtt tttacaatgc ttgaacacat   1440

aaaccttaga aaactggaaa atacgtgtcc acagaaagag ttattagcta ctaccttatg   1500

taaagatgca tagaaaatga aattgttgga aacatgtgca caaagtgttt tatattatat   1560

acattgtatt tatgaagaat aaataaaata ttaagattgt tttcctgcta gccaagagaa   1620

gaaatccttg ggaaatatct aaggagtata tggggcttta taagcactgt ttctaaaaga   1680

tattctctgg tacttttgca aaaagtcgac tgtgactgtg tagcattatg ttctgtagaa   1740

tttttttcaa gtagcataat ttatttcatt ggtgtgaaaa cagccaaagg ttccaatatc   1800

ctcacaaatc atttatgcca aacatctgag ggcaaaattt agccggtgtt atttactaga   1860

ttcttccctt tgaactcaca gactcaagag acagaccaag agttcttata tactcaccac   1920

agcggaccaa tccaagtggc atttttagga aaggttgcag catttaatgc catgtggtat   1980

gtctgttcgt caagtgggtg gcaagggaat atccaagctg gcattttgga tatgatgggc   2040

cttttacttt cctgagtgac atgccacatg tcaagaaata ctgctcccca cccccccact   2100

cccatcacat ttacgtgaac aattttcatt tagttatttc ccgttccata tggtgttaaa   2160

acagtcgtat taaataaaga ttatttctag ttttcagtgg taatttaaat gagaggatat   2220

gtaataattg cttattagat acttatccaa atgaaatata acagagttta cagtacttaa   2280

aatggctggt tatggtcttg gaaatgtttg aaaattcatt atcctgaaaa aaactttacc   2340

attctgtttt acccttgagg tattttttgg ggaaaaatgt ttttgataac tattaatcta   2400

aatatagtat aattataggc aaatttcact gcctagtttt attgatatcc tgagtctaca   2460

gctagtccat tcgtatgact gattgattta tgatagctcc agagaaccat aaatttcaaa   2520

ggctaaactc tctgatttta gtaaatagta ggtaaagtga cacaatatat gtttacacaa   2580

cactgttttc atgaaatgca aactttgcaa aactcacatt aactgggaag cagccaaccc   2640

tctgtagaga aatcccagat tgggagtctg gtttgaatct ttgaagacag aaaggtgata   2700

tccggcctgc tgttttaaag ggaccacact tttgaatacc tactggtgtt tggcagaaat   2760

ctgagactgg caccagacac aaattttaga catgggtatc ttccctccag taattcactg   2820

ctcagagtaa tttagaagac aaaaacagaa aaaattgtaa tgatttttta agtgttagaa   2880

tatgtttgtt aacatactct gcaaaataaa tttcaactaa tgcaatagac ttaaaatata   2940

gcctatggaa tactgtgatt gaagtttgaa ggcttgctgg ttcttatttt gcatgcaagt   3000

ttagacaggg taaagaatgt ataaatttat ttgagatgag atacagtatt gtaaaaatat   3060

aacctcatct agaattgctt ttaaaacaag caaaagccta ttttagtaca aatgtagggt   3120

gggtagttgt tttaaggtag caaaatactt caagattttc tatcttttta atttttcatg   3180

aagacagaag aaatactttc accccaacca atgactgtaa gatcttgaga gtatgttctt   3240

actcatttct gtaattgcag tagtgtagtc atctgcatat aaatttaata aatgcatgtt   3300

aaaatttaag ttgatgcctt ttagtcctct cagagtctgt cacagtttct ttgtgtaaat   3360

gataaaaaag tttgaattta atcaataaaa cttaaaaatc acaatatc                3408


<210>  4931
<211>  54
<212>  PRT
<213>  Homosapiens

<400>  4931

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Thr His His Gly Cys 
    50                  


<210>  4932
<211>  3622
<212>  DNA
<213>  Homosapiens

<400>  4932
ctggcttgtc ccgcccctgc ccctgagtga cagaaccgtg gacagcaaca tttcccacag     60

gacacgaagt ttgtcggccc ttgccttggc agagctgagc aatatgaaac agaaaaacaa    120

gttggttgga tagctgtcct ccatgcagtc attcatgatc caggctgtca tcatcttcat    180

cactcatgtt cagagttacc ctagaggtca tctccatttc atccagataa atgagtatgc    240

aaggaacgtt tttataggca ttttggagat caaagatggg tagaaaagat gctgctacta    300

taaaacttcc tgttgatcag tacagaaaac aaattggtaa acaggattat aaaaaaacta    360

aacctatttt acgagcaacc aaattaaaag cagaagcaaa gaaaacagca ataggcataa    420

aggaagttgg ccttgtactt gcagctatat tggcactact actggctttc tatgctttct    480

tttatctcag actcaccacg gatgttgacc ctgatctgga ccaagatgaa gattagctaa    540

gcaacaatca atgcatgaaa gagaaataac tttacgaaag caccttttgg gaccaaaact    600

ttcaatactg aaactgtaac atctttaatt ctttctgcta atattttcag tttgcagaca    660

tatgattttt gatagttgca taggatgtca ggaaaagaac cttacctagc aatgcagtat    720

agtatgtgct actggatact tttatatatc tttctgcttt gacagccacc ctatacatgg    780

tacatttaga tgaaatggga accagatcct aaatttttca aatgtcattg ccaatttatg    840

tgtataattc catcacttcc tgatgagtaa gtctattttt gttctatata catcataagt    900

tagtatatat tcttatttac agaaacatgc tcaaatcaca ttcagaaaga acaaaaagtc    960

atgggaaatt ttttatttta caacaaagcc ctgctttctt tctggacgta ttttacatca   1020

ttagagagac tatctgcaca tacatctacc ataatctttt tccttctttg ccaactgttc   1080

agtgcacatg tgctgcatca gaaatggcac ctggatgaca gaagctcaaa gagtcacata   1140

tgtctctaaa atagagttct tttcctcttg ggctgtctga actggtgtaa atagaagctc   1200

agttgatctt ggttttaatt aacttattac tctattaata taaccttgga attctattct   1260

aattatgttg ttctggctgc ttgtagtatc agttcgcccc tcttgttagg gagatatgta   1320

acaatctgtc atttaattga gcagtctttt tcacataaca gtaatagcaa aaatcctacc   1380

tactcagaat catcttctta ggttgtctcc taaatctgaa caatacagtt gttttataaa   1440

attacatttt gtctcttgag atttaatcaa ttagaactct ttagggagaa aataaataat   1500

agaagaaaat atatgcctca tatttcatat gtaattatct gttgatataa tttttcaatg   1560

tattttgtat ttgtgggagc ataatgacct gtacattcaa tatttttact ggtaattcaa   1620

tttttaaata tgtttttaca atgcttgaac acataaacct tagaaaactg gaaaatacgt   1680

gtccacagaa agagttatta gctactacct tatgtaaaga tgcatagaaa atgaaattgt   1740

tggaaacatg tgcacaaagt gttttatatt atatacattg tatttatgaa gaataaataa   1800

aatattaaga ttgttttcct gctagccaag agaagaaatc cttgggaaat atctaaggag   1860

tatatggggc tttataagca ctgtttctaa aagatattct ctggtacttt tgcaaaaagt   1920

cgactgtgac tgtgtagcat tatgttctgt agaatttttt tcaagtagca taatttattt   1980

cattggtgtg aaaacagcca aaggttccaa tatcctcaca aatcatttat gccaaacatc   2040

tgagggcaaa atttagccgg tgttatttac tagattcttc cctttgaact cacagactca   2100

agagacagac caagagttct tatatactca ccacagcgga ccaatccaag tggcattttt   2160

aggaaaggtt gcagcattta atgccatgtg gtatgtctgt tcgtcaagtg ggtggcaagg   2220

gaatatccaa gctggcattt tggatatgat gggcctttta ctttcctgag tgacatgcca   2280

catgtcaaga aatactgctc cccacccccc cactcccatc acatttacgt gaacaatttt   2340

catttagtta tttcccgttc catatggtgt taaaacagtc gtattaaata aagattattt   2400

ctagttttca gtggtaattt aaatgagagg atatgtaata attgcttatt agatacttat   2460

ccaaatgaaa tataacagag tttacagtac ttaaaatggc tggttatggt cttggaaatg   2520

tttgaaaatt cattatcctg aaaaaaactt taccattctg ttttaccctt gaggtatttt   2580

ttggggaaaa atgtttttga taactattaa tctaaatata gtataattat aggcaaattt   2640

cactgcctag ttttattgat atcctgagtc tacagctagt ccattcgtat gactgattga   2700

tttatgatag ctccagagaa ccataaattt caaaggctaa actctctgat tttagtaaat   2760

agtaggtaaa gtgacacaat atatgtttac acaacactgt tttcatgaaa tgcaaacttt   2820

gcaaaactca cattaactgg gaagcagcca accctctgta gagaaatccc agattgggag   2880

tctggtttga atctttgaag acagaaaggt gatatccggc ctgctgtttt aaagggacca   2940

cacttttgaa tacctactgg tgtttggcag aaatctgaga ctggcaccag acacaaattt   3000

tagacatggg tatcttccct ccagtaattc actgctcaga gtaatttaga agacaaaaac   3060

agaaaaaatt gtaatgattt tttaagtgtt agaatatgtt tgttaacata ctctgcaaaa   3120

taaatttcaa ctaatgcaat agacttaaaa tatagcctat ggaatactgt gattgaagtt   3180

tgaaggcttg ctggttctta ttttgcatgc aagtttagac agggtaaaga atgtataaat   3240

ttatttgaga tgagatacag tattgtaaaa atataacctc atctagaatt gcttttaaaa   3300

caagcaaaag cctattttag tacaaatgta gggtgggtag ttgttttaag gtagcaaaat   3360

acttcaagat tttctatctt tttaattttt catgaagaca gaagaaatac tttcacccca   3420

accaatgact gtaagatctt gagagtatgt tcttactcat ttctgtaatt gcagtagtgt   3480

agtcatctgc atataaattt aataaatgca tgttaaaatt taagttgatg ccttttagtc   3540

ctctcagagt ctgtcacagt ttctttgtgt aaatgataaa aaagtttgaa tttaatcaat   3600

aaaacttaaa aatcacaata tc                                            3622


<210>  4933
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  4933

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  4934
<211>  3586
<212>  DNA
<213>  Homosapiens

<400>  4934
gcaattctgg cctctccagc ctcttgcctt tcttctgagg ggagcctttt atcctgctgt     60

aagaaaaatc accaagaata ttatttttgg tatttggaat tgaatttgcc aggaatgcaa    120

gcactgctac ctaactaaag accttggctt tggaaacatc ttaccccttg gcagctctcc    180

agagtttaga cttggcagca tcaaagacac aacgcaagca ggcattttgg agatcaaaga    240

tgggtagaaa agatgctgct actataaaac ttcctgttga tcagtacaga aaacaaattg    300

gtaaacagga ttataaaaaa actaaaccta ttttacgagc aaccaaatta aaagcagaag    360

caaagaaaac agcaataggc ataaaggaag ttggccttgt acttgcagct atattggcac    420

tactactggc tttctatgct ttcttttatc tcagactcac cacggatgtt gaccctgatc    480

tggaccaaga tgaagattag ctaagcaaca atcaatgcat gaaagagaaa taactttacg    540

aaagcacctt ttgggaccaa aactttcaat actgaaactg taacatcttt aattctttct    600

gctaatattt tcagtttgca gacatatgat ttttgatagt tgcataggat gtcaggaaaa    660

gaaccttacc tagcaatgca gtatagtatg tgctactgga tacttttata tatctttctg    720

ctttgacagc caccctatac atggtacatt tagatgaaat gggaaccaga tcctaaattt    780

ttcaaatgtc attgccaatt tatgtgtata attccatcac ttcctgatga gtaagtctat    840

ttttgttcta tatacatcat aagttagtat atattcttat ttacagaaac atgctcaaat    900

cacattcaga aagaacaaaa agtcatggga aattttttat tttacaacaa agccctgctt    960

tctttctgga cgtattttac atcattagag agactatctg cacatacatc taccataatc   1020

tttttccttc tttgccaact gttcagtgca catgtgctgc atcagaaatg gcacctggat   1080

gacagaagct caaagagtca catatgtctc taaaatagag ttcttttcct cttgggctgt   1140

ctgaactggt gtaaatagaa gctcagttga tcttggtttt aattaactta ttactctatt   1200

aatataacct tggaattcta ttctaattat gttgttctgg ctgcttgtag tatcagttcg   1260

cccctcttgt tagggagata tgtaacaatc tgtcatttaa ttgagcagtc tttttcacat   1320

aacagtaata gcaaaaatcc tacctactca gaatcatctt cttaggttgt ctcctaaatc   1380

tgaacaatac agttgtttta taaaattaca ttttgtctct tgagatttaa tcaattagaa   1440

ctctttaggg agaaaataaa taatagaaga aaatatatgc ctcatatttc atatgtaatt   1500

atctgttgat ataatttttc aatgtatttt gtatttgtgg gagcataatg acctgtacat   1560

tcaatatttt tactggtaat tcaattttta aatatgtttt tacaatgctt gaacacataa   1620

accttagaaa actggaaaat acgtgtccac agaaagagtt attagctact accttatgta   1680

aagatgcata gaaaatgaaa ttgttggaaa catgtgcaca aagtgtttta tattatatac   1740

attgtattta tgaagaataa ataaaatatt aagattgttt tcctgctagc caagagaaga   1800

aatccttggg aaatatctaa ggagtatatg gggctttata agcactgttt ctaaaagata   1860

ttctctggta cttttgcaaa aagtcgactg tgactgtgta gcattatgtt ctgtagaatt   1920

tttttcaagt agcataattt atttcattgg tgtgaaaaca gccaaaggtt ccaatatcct   1980

cacaaatcat ttatgccaaa catctgaggg caaaatttag ccggtgttat ttactagatt   2040

cttccctttg aactcacaga ctcaagagac agaccaagag ttcttatata ctcaccacag   2100

cggaccaatc caagtggcat ttttaggaaa ggttgcagca tttaatgcca tgtggtatgt   2160

ctgttcgtca agtgggtggc aagggaatat ccaagctggc attttggata tgatgggcct   2220

tttactttcc tgagtgacat gccacatgtc aagaaatact gctccccacc cccccactcc   2280

catcacattt acgtgaacaa ttttcattta gttatttccc gttccatatg gtgttaaaac   2340

agtcgtatta aataaagatt atttctagtt ttcagtggta atttaaatga gaggatatgt   2400

aataattgct tattagatac ttatccaaat gaaatataac agagtttaca gtacttaaaa   2460

tggctggtta tggtcttgga aatgtttgaa aattcattat cctgaaaaaa actttaccat   2520

tctgttttac ccttgaggta ttttttgggg aaaaatgttt ttgataacta ttaatctaaa   2580

tatagtataa ttataggcaa atttcactgc ctagttttat tgatatcctg agtctacagc   2640

tagtccattc gtatgactga ttgatttatg atagctccag agaaccataa atttcaaagg   2700

ctaaactctc tgattttagt aaatagtagg taaagtgaca caatatatgt ttacacaaca   2760

ctgttttcat gaaatgcaaa ctttgcaaaa ctcacattaa ctgggaagca gccaaccctc   2820

tgtagagaaa tcccagattg ggagtctggt ttgaatcttt gaagacagaa aggtgatatc   2880

cggcctgctg ttttaaaggg accacacttt tgaataccta ctggtgtttg gcagaaatct   2940

gagactggca ccagacacaa attttagaca tgggtatctt ccctccagta attcactgct   3000

cagagtaatt tagaagacaa aaacagaaaa aattgtaatg attttttaag tgttagaata   3060

tgtttgttaa catactctgc aaaataaatt tcaactaatg caatagactt aaaatatagc   3120

ctatggaata ctgtgattga agtttgaagg cttgctggtt cttattttgc atgcaagttt   3180

agacagggta aagaatgtat aaatttattt gagatgagat acagtattgt aaaaatataa   3240

cctcatctag aattgctttt aaaacaagca aaagcctatt ttagtacaaa tgtagggtgg   3300

gtagttgttt taaggtagca aaatacttca agattttcta tctttttaat ttttcatgaa   3360

gacagaagaa atactttcac cccaaccaat gactgtaaga tcttgagagt atgttcttac   3420

tcatttctgt aattgcagta gtgtagtcat ctgcatataa atttaataaa tgcatgttaa   3480

aatttaagtt gatgcctttt agtcctctca gagtctgtca cagtttcttt gtgtaaatga   3540

taaaaaagtt tgaatttaat caataaaact taaaaatcac aatatc                  3586


<210>  4935
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  4935

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  4936
<211>  4070
<212>  DNA
<213>  Homosapiens

<400>  4936
attaactaaa caagtcacag tctttatttt taatttctac agtcacctcg tgagacaggt     60

attagaactc cggagtggca tcaaaatgag ggaaaggcct cagggccagc gcctttgcgt    120

cctggaccgg cgtacagacg ggagaaaggc cgaccaatcc gagagcaggc tgaggcctgg    180

tcccgcccct gggggcagag cctcgcctct tttccgcctc accctttggg agtaggggtg    240

tgcggctggc ttgtcccgcc cctgcccctg agtgacagaa ccgtggacag caacatttcc    300

cacaggacac gaagtttgtc ggcccttgcc ttggcagagc tgaggtgtgt gtccggcgag    360

tgcgagggga ttggggagac cctgcccggg aagctcgggg tccgggaatg aaagcgggcg    420

cacctcttta gcgagcccta aagcgtttgg gagacgatcg ttccgtccct gggagcggca    480

cttggtgggg ctgggcggag ggaggctctg caagagaaac ccggagtccg ggaaacccag    540

tagtaagaaa aatcaccaag aatattattt ttggtatttg gaattgaatt tgccaggaat    600

gcaagcactg ctacctaact aaagaccttg gctttggaaa catcttaccc cttggcagct    660

ctccagagtt tagacttggc agcatcaaag acacaacgca agcaggcatt ttggagatca    720

aagatgggta gaaaagatgc tgctactata aaacttcctg ttgatcagta cagaaaacaa    780

attggtaaac aggattataa aaaaactaaa cctattttac gagcaaccaa attaaaagca    840

gaagcaaaga aaacagcaat aggcataaag gaagttggcc ttgtacttgc agctatattg    900

gcactactac tggctttcta tgctttcttt tatctcagac tcaccacgga tgttgaccct    960

gatctggacc aagatgaaga ttagctaagc aacaatcaat gcatgaaaga gaaataactt   1020

tacgaaagca ccttttggga ccaaaacttt caatactgaa actgtaacat ctttaattct   1080

ttctgctaat attttcagtt tgcagacata tgatttttga tagttgcata ggatgtcagg   1140

aaaagaacct tacctagcaa tgcagtatag tatgtgctac tggatacttt tatatatctt   1200

tctgctttga cagccaccct atacatggta catttagatg aaatgggaac cagatcctaa   1260

atttttcaaa tgtcattgcc aatttatgtg tataattcca tcacttcctg atgagtaagt   1320

ctatttttgt tctatataca tcataagtta gtatatattc ttatttacag aaacatgctc   1380

aaatcacatt cagaaagaac aaaaagtcat gggaaatttt ttattttaca acaaagccct   1440

gctttctttc tggacgtatt ttacatcatt agagagacta tctgcacata catctaccat   1500

aatctttttc cttctttgcc aactgttcag tgcacatgtg ctgcatcaga aatggcacct   1560

ggatgacaga agctcaaaga gtcacatatg tctctaaaat agagttcttt tcctcttggg   1620

ctgtctgaac tggtgtaaat agaagctcag ttgatcttgg ttttaattaa cttattactc   1680

tattaatata accttggaat tctattctaa ttatgttgtt ctggctgctt gtagtatcag   1740

ttcgcccctc ttgttaggga gatatgtaac aatctgtcat ttaattgagc agtctttttc   1800

acataacagt aatagcaaaa atcctaccta ctcagaatca tcttcttagg ttgtctccta   1860

aatctgaaca atacagttgt tttataaaat tacattttgt ctcttgagat ttaatcaatt   1920

agaactcttt agggagaaaa taaataatag aagaaaatat atgcctcata tttcatatgt   1980

aattatctgt tgatataatt tttcaatgta ttttgtattt gtgggagcat aatgacctgt   2040

acattcaata tttttactgg taattcaatt tttaaatatg tttttacaat gcttgaacac   2100

ataaacctta gaaaactgga aaatacgtgt ccacagaaag agttattagc tactacctta   2160

tgtaaagatg catagaaaat gaaattgttg gaaacatgtg cacaaagtgt tttatattat   2220

atacattgta tttatgaaga ataaataaaa tattaagatt gttttcctgc tagccaagag   2280

aagaaatcct tgggaaatat ctaaggagta tatggggctt tataagcact gtttctaaaa   2340

gatattctct ggtacttttg caaaaagtcg actgtgactg tgtagcatta tgttctgtag   2400

aatttttttc aagtagcata atttatttca ttggtgtgaa aacagccaaa ggttccaata   2460

tcctcacaaa tcatttatgc caaacatctg agggcaaaat ttagccggtg ttatttacta   2520

gattcttccc tttgaactca cagactcaag agacagacca agagttctta tatactcacc   2580

acagcggacc aatccaagtg gcatttttag gaaaggttgc agcatttaat gccatgtggt   2640

atgtctgttc gtcaagtggg tggcaaggga atatccaagc tggcattttg gatatgatgg   2700

gccttttact ttcctgagtg acatgccaca tgtcaagaaa tactgctccc caccccccca   2760

ctcccatcac atttacgtga acaattttca tttagttatt tcccgttcca tatggtgtta   2820

aaacagtcgt attaaataaa gattatttct agttttcagt ggtaatttaa atgagaggat   2880

atgtaataat tgcttattag atacttatcc aaatgaaata taacagagtt tacagtactt   2940

aaaatggctg gttatggtct tggaaatgtt tgaaaattca ttatcctgaa aaaaacttta   3000

ccattctgtt ttacccttga ggtatttttt ggggaaaaat gtttttgata actattaatc   3060

taaatatagt ataattatag gcaaatttca ctgcctagtt ttattgatat cctgagtcta   3120

cagctagtcc attcgtatga ctgattgatt tatgatagct ccagagaacc ataaatttca   3180

aaggctaaac tctctgattt tagtaaatag taggtaaagt gacacaatat atgtttacac   3240

aacactgttt tcatgaaatg caaactttgc aaaactcaca ttaactggga agcagccaac   3300

cctctgtaga gaaatcccag attgggagtc tggtttgaat ctttgaagac agaaaggtga   3360

tatccggcct gctgttttaa agggaccaca cttttgaata cctactggtg tttggcagaa   3420

atctgagact ggcaccagac acaaatttta gacatgggta tcttccctcc agtaattcac   3480

tgctcagagt aatttagaag acaaaaacag aaaaaattgt aatgattttt taagtgttag   3540

aatatgtttg ttaacatact ctgcaaaata aatttcaact aatgcaatag acttaaaata   3600

tagcctatgg aatactgtga ttgaagtttg aaggcttgct ggttcttatt ttgcatgcaa   3660

gtttagacag ggtaaagaat gtataaattt atttgagatg agatacagta ttgtaaaaat   3720

ataacctcat ctagaattgc ttttaaaaca agcaaaagcc tattttagta caaatgtagg   3780

gtgggtagtt gttttaaggt agcaaaatac ttcaagattt tctatctttt taatttttca   3840

tgaagacaga agaaatactt tcaccccaac caatgactgt aagatcttga gagtatgttc   3900

ttactcattt ctgtaattgc agtagtgtag tcatctgcat ataaatttaa taaatgcatg   3960

ttaaaattta agttgatgcc ttttagtcct ctcagagtct gtcacagttt ctttgtgtaa   4020

atgataaaaa agtttgaatt taatcaataa aacttaaaaa tcacaatatc              4070


<210>  4937
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  4937

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  4938
<211>  3768
<212>  DNA
<213>  Homosapiens

<400>  4938
cccctgcccc tgagtgacag aaccgtggac agcaacattt cccacaggac acgaagtttg     60

tcggcccttg ccttggcaga gctgagtaag aaaaatcacc aagaatatta tttttggtat    120

ttggaattga atttgccagg aatgcaagca ctgctaccta actaaagacc ttggctttgg    180

aaacatctta ccccttggca gctctccaga gtttagactt ggcagcatca aagacacaac    240

gcaagcaata tgaaacagaa aaacaagttg gttggatagc tgtcctccat gcagtcattc    300

atgatccagg ctgtcatcat cttcatcact catgttcaga gttaccctag aggtcatctc    360

catttcatcc agataaatga gtatgcaagg aacgttttta taggcatttt ggagatcaaa    420

gatgggtaga aaagatgctg ctactataaa acttcctgtt gatcagtaca gaaaacaaat    480

tggtaaacag gattataaaa aaactaaacc tattttacga gcaaccaaat taaaagcaga    540

agcaaagaaa acagcaatag gcataaagga agttggcctt gtacttgcag ctatattggc    600

actactactg gctttctatg ctttctttta tctcagactc accacggatg ttgaccctga    660

tctggaccaa gatgaagatt agctaagcaa caatcaatgc atgaaagaga aataacttta    720

cgaaagcacc ttttgggacc aaaactttca atactgaaac tgtaacatct ttaattcttt    780

ctgctaatat tttcagtttg cagacatatg atttttgata gttgcatagg atgtcaggaa    840

aagaacctta cctagcaatg cagtatagta tgtgctactg gatactttta tatatctttc    900

tgctttgaca gccaccctat acatggtaca tttagatgaa atgggaacca gatcctaaat    960

ttttcaaatg tcattgccaa tttatgtgta taattccatc acttcctgat gagtaagtct   1020

atttttgttc tatatacatc ataagttagt atatattctt atttacagaa acatgctcaa   1080

atcacattca gaaagaacaa aaagtcatgg gaaatttttt attttacaac aaagccctgc   1140

tttctttctg gacgtatttt acatcattag agagactatc tgcacataca tctaccataa   1200

tctttttcct tctttgccaa ctgttcagtg cacatgtgct gcatcagaaa tggcacctgg   1260

atgacagaag ctcaaagagt cacatatgtc tctaaaatag agttcttttc ctcttgggct   1320

gtctgaactg gtgtaaatag aagctcagtt gatcttggtt ttaattaact tattactcta   1380

ttaatataac cttggaattc tattctaatt atgttgttct ggctgcttgt agtatcagtt   1440

cgcccctctt gttagggaga tatgtaacaa tctgtcattt aattgagcag tctttttcac   1500

ataacagtaa tagcaaaaat cctacctact cagaatcatc ttcttaggtt gtctcctaaa   1560

tctgaacaat acagttgttt tataaaatta cattttgtct cttgagattt aatcaattag   1620

aactctttag ggagaaaata aataatagaa gaaaatatat gcctcatatt tcatatgtaa   1680

ttatctgttg atataatttt tcaatgtatt ttgtatttgt gggagcataa tgacctgtac   1740

attcaatatt tttactggta attcaatttt taaatatgtt tttacaatgc ttgaacacat   1800

aaaccttaga aaactggaaa atacgtgtcc acagaaagag ttattagcta ctaccttatg   1860

taaagatgca tagaaaatga aattgttgga aacatgtgca caaagtgttt tatattatat   1920

acattgtatt tatgaagaat aaataaaata ttaagattgt tttcctgcta gccaagagaa   1980

gaaatccttg ggaaatatct aaggagtata tggggcttta taagcactgt ttctaaaaga   2040

tattctctgg tacttttgca aaaagtcgac tgtgactgtg tagcattatg ttctgtagaa   2100

tttttttcaa gtagcataat ttatttcatt ggtgtgaaaa cagccaaagg ttccaatatc   2160

ctcacaaatc atttatgcca aacatctgag ggcaaaattt agccggtgtt atttactaga   2220

ttcttccctt tgaactcaca gactcaagag acagaccaag agttcttata tactcaccac   2280

agcggaccaa tccaagtggc atttttagga aaggttgcag catttaatgc catgtggtat   2340

gtctgttcgt caagtgggtg gcaagggaat atccaagctg gcattttgga tatgatgggc   2400

cttttacttt cctgagtgac atgccacatg tcaagaaata ctgctcccca cccccccact   2460

cccatcacat ttacgtgaac aattttcatt tagttatttc ccgttccata tggtgttaaa   2520

acagtcgtat taaataaaga ttatttctag ttttcagtgg taatttaaat gagaggatat   2580

gtaataattg cttattagat acttatccaa atgaaatata acagagttta cagtacttaa   2640

aatggctggt tatggtcttg gaaatgtttg aaaattcatt atcctgaaaa aaactttacc   2700

attctgtttt acccttgagg tattttttgg ggaaaaatgt ttttgataac tattaatcta   2760

aatatagtat aattataggc aaatttcact gcctagtttt attgatatcc tgagtctaca   2820

gctagtccat tcgtatgact gattgattta tgatagctcc agagaaccat aaatttcaaa   2880

ggctaaactc tctgatttta gtaaatagta ggtaaagtga cacaatatat gtttacacaa   2940

cactgttttc atgaaatgca aactttgcaa aactcacatt aactgggaag cagccaaccc   3000

tctgtagaga aatcccagat tgggagtctg gtttgaatct ttgaagacag aaaggtgata   3060

tccggcctgc tgttttaaag ggaccacact tttgaatacc tactggtgtt tggcagaaat   3120

ctgagactgg caccagacac aaattttaga catgggtatc ttccctccag taattcactg   3180

ctcagagtaa tttagaagac aaaaacagaa aaaattgtaa tgatttttta agtgttagaa   3240

tatgtttgtt aacatactct gcaaaataaa tttcaactaa tgcaatagac ttaaaatata   3300

gcctatggaa tactgtgatt gaagtttgaa ggcttgctgg ttcttatttt gcatgcaagt   3360

ttagacaggg taaagaatgt ataaatttat ttgagatgag atacagtatt gtaaaaatat   3420

aacctcatct agaattgctt ttaaaacaag caaaagccta ttttagtaca aatgtagggt   3480

gggtagttgt tttaaggtag caaaatactt caagattttc tatcttttta atttttcatg   3540

aagacagaag aaatactttc accccaacca atgactgtaa gatcttgaga gtatgttctt   3600

actcatttct gtaattgcag tagtgtagtc atctgcatat aaatttaata aatgcatgtt   3660

aaaatttaag ttgatgcctt ttagtcctct cagagtctgt cacagtttct ttgtgtaaat   3720

gataaaaaag tttgaattta atcaataaaa cttaaaaatc acaatatc                3768


<210>  4939
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  4939

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  4940
<211>  3656
<212>  DNA
<213>  Homosapiens

<400>  4940
tccgcctcac cctttgggag taggggtgtg cggctggctt gtcccgcccc tgcccctgag     60

tgacagaacc gtggacagca acatttccca caggacacga agtttgtcgg cccttgcctt    120

ggcagagctg agtaagaaaa atcaccaaga atattatttt tggtatttgg aattgaattt    180

gccaggaatg caagcactgc tacctaacta aagaccttgg ctttggaaac atcttacccc    240

ttggcagctc tccagagttt agacttggca gcatcaaaga cacaacgcaa ggcattttgg    300

agatcaaaga tgggtagaaa agatgctgct actataaaac ttcctgttga tcagtacaga    360

aaacaaattg gtaaacagga ttataaaaaa actaaaccta ttttacgagc aaccaaatta    420

aaagcagaag caaagaaaac agcaataggc ataaaggaag ttggccttgt acttgcagct    480

atattggcac tactactggc tttctatgct ttcttttatc tcagactcac cacggatgtt    540

gaccctgatc tggaccaaga tgaagattag ctaagcaaca atcaatgcat gaaagagaaa    600

taactttacg aaagcacctt ttgggaccaa aactttcaat actgaaactg taacatcttt    660

aattctttct gctaatattt tcagtttgca gacatatgat ttttgatagt tgcataggat    720

gtcaggaaaa gaaccttacc tagcaatgca gtatagtatg tgctactgga tacttttata    780

tatctttctg ctttgacagc caccctatac atggtacatt tagatgaaat gggaaccaga    840

tcctaaattt ttcaaatgtc attgccaatt tatgtgtata attccatcac ttcctgatga    900

gtaagtctat ttttgttcta tatacatcat aagttagtat atattcttat ttacagaaac    960

atgctcaaat cacattcaga aagaacaaaa agtcatggga aattttttat tttacaacaa   1020

agccctgctt tctttctgga cgtattttac atcattagag agactatctg cacatacatc   1080

taccataatc tttttccttc tttgccaact gttcagtgca catgtgctgc atcagaaatg   1140

gcacctggat gacagaagct caaagagtca catatgtctc taaaatagag ttcttttcct   1200

cttgggctgt ctgaactggt gtaaatagaa gctcagttga tcttggtttt aattaactta   1260

ttactctatt aatataacct tggaattcta ttctaattat gttgttctgg ctgcttgtag   1320

tatcagttcg cccctcttgt tagggagata tgtaacaatc tgtcatttaa ttgagcagtc   1380

tttttcacat aacagtaata gcaaaaatcc tacctactca gaatcatctt cttaggttgt   1440

ctcctaaatc tgaacaatac agttgtttta taaaattaca ttttgtctct tgagatttaa   1500

tcaattagaa ctctttaggg agaaaataaa taatagaaga aaatatatgc ctcatatttc   1560

atatgtaatt atctgttgat ataatttttc aatgtatttt gtatttgtgg gagcataatg   1620

acctgtacat tcaatatttt tactggtaat tcaattttta aatatgtttt tacaatgctt   1680

gaacacataa accttagaaa actggaaaat acgtgtccac agaaagagtt attagctact   1740

accttatgta aagatgcata gaaaatgaaa ttgttggaaa catgtgcaca aagtgtttta   1800

tattatatac attgtattta tgaagaataa ataaaatatt aagattgttt tcctgctagc   1860

caagagaaga aatccttggg aaatatctaa ggagtatatg gggctttata agcactgttt   1920

ctaaaagata ttctctggta cttttgcaaa aagtcgactg tgactgtgta gcattatgtt   1980

ctgtagaatt tttttcaagt agcataattt atttcattgg tgtgaaaaca gccaaaggtt   2040

ccaatatcct cacaaatcat ttatgccaaa catctgaggg caaaatttag ccggtgttat   2100

ttactagatt cttccctttg aactcacaga ctcaagagac agaccaagag ttcttatata   2160

ctcaccacag cggaccaatc caagtggcat ttttaggaaa ggttgcagca tttaatgcca   2220

tgtggtatgt ctgttcgtca agtgggtggc aagggaatat ccaagctggc attttggata   2280

tgatgggcct tttactttcc tgagtgacat gccacatgtc aagaaatact gctccccacc   2340

cccccactcc catcacattt acgtgaacaa ttttcattta gttatttccc gttccatatg   2400

gtgttaaaac agtcgtatta aataaagatt atttctagtt ttcagtggta atttaaatga   2460

gaggatatgt aataattgct tattagatac ttatccaaat gaaatataac agagtttaca   2520

gtacttaaaa tggctggtta tggtcttgga aatgtttgaa aattcattat cctgaaaaaa   2580

actttaccat tctgttttac ccttgaggta ttttttgggg aaaaatgttt ttgataacta   2640

ttaatctaaa tatagtataa ttataggcaa atttcactgc ctagttttat tgatatcctg   2700

agtctacagc tagtccattc gtatgactga ttgatttatg atagctccag agaaccataa   2760

atttcaaagg ctaaactctc tgattttagt aaatagtagg taaagtgaca caatatatgt   2820

ttacacaaca ctgttttcat gaaatgcaaa ctttgcaaaa ctcacattaa ctgggaagca   2880

gccaaccctc tgtagagaaa tcccagattg ggagtctggt ttgaatcttt gaagacagaa   2940

aggtgatatc cggcctgctg ttttaaaggg accacacttt tgaataccta ctggtgtttg   3000

gcagaaatct gagactggca ccagacacaa attttagaca tgggtatctt ccctccagta   3060

attcactgct cagagtaatt tagaagacaa aaacagaaaa aattgtaatg attttttaag   3120

tgttagaata tgtttgttaa catactctgc aaaataaatt tcaactaatg caatagactt   3180

aaaatatagc ctatggaata ctgtgattga agtttgaagg cttgctggtt cttattttgc   3240

atgcaagttt agacagggta aagaatgtat aaatttattt gagatgagat acagtattgt   3300

aaaaatataa cctcatctag aattgctttt aaaacaagca aaagcctatt ttagtacaaa   3360

tgtagggtgg gtagttgttt taaggtagca aaatacttca agattttcta tctttttaat   3420

ttttcatgaa gacagaagaa atactttcac cccaaccaat gactgtaaga tcttgagagt   3480

atgttcttac tcatttctgt aattgcagta gtgtagtcat ctgcatataa atttaataaa   3540

tgcatgttaa aatttaagtt gatgcctttt agtcctctca gagtctgtca cagtttcttt   3600

gtgtaaatga taaaaaagtt tgaatttaat caataaaact taaaaatcac aatatc       3656


<210>  4941
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  4941

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  4942
<211>  4289
<212>  DNA
<213>  Homosapiens

<400>  4942
attaactaaa caagtcacag tctttatttt taatttctac agtcacctcg tgagacaggt     60

attagaactc cggagtggca tcaaaatgag ggaaaggcct cagggccagc gcctttgcgt    120

cctggaccgg cgtacagacg ggagaaaggc cgaccaatcc gagagcaggc tgaggcctgg    180

tcccgcccct gggggcagag cctcgcctct tttccgcctc accctttggg agtaggggtg    240

tgcggctggc ttgtcccgcc cctgcccctg agtgacagaa ccgtggacag caacatttcc    300

cacaggacac gaagtttgtc ggcccttgcc ttggcagagc tgaggtgtgt gtccggcgag    360

tgcgagggga ttggggagac cctgcccggg aagctcgggg tccgggaatg aaagcgggcg    420

cacctcttta gcgagcccta aagcgtttgg gagacgatcg ttccgtccct gggagcggca    480

cttggtgggg ctgggcggag ggaggctctg caagagaaac ccggagtccg ggaaacccag    540

tagtttctgg aggctgctca cattccttgg cttatggcct ccttcttcca acgtcaaagc    600

cagcaacatt gcagcaatct gacttatttt gttgtcatgt ctcctgacca catctggaag    660

ggttatctac ttttgaagac acatccagat aattcaggac aatctgtcca ttttgaggtt    720

cttcattgaa tcatgtctgc aaagtccctt ctgcaatcta agtaagaaaa atcaccaaga    780

atattatttt tggtatttgg aattgaattt gccaggaatg caagcactgc tacctaacta    840

aagaccttgg ctttggaaac atcttacccc ttggcagctc tccagagttt agacttggca    900

gcatcaaaga cacaacgcaa gcaggcattt tggagatcaa agatgggtag aaaagatgct    960

gctactataa aacttcctgt tgatcagtac agaaaacaaa ttggtaaaca ggattataaa   1020

aaaactaaac ctattttacg agcaaccaaa ttaaaagcag aagcaaagaa aacagcaata   1080

ggcataaagg aagttggcct tgtacttgca gctatattgg cactactact ggctttctat   1140

gctttctttt atctcagact caccacggat gttgaccctg atctggacca agatgaagat   1200

tagctaagca acaatcaatg catgaaagag aaataacttt acgaaagcac cttttgggac   1260

caaaactttc aatactgaaa ctgtaacatc tttaattctt tctgctaata ttttcagttt   1320

gcagacatat gatttttgat agttgcatag gatgtcagga aaagaacctt acctagcaat   1380

gcagtatagt atgtgctact ggatactttt atatatcttt ctgctttgac agccacccta   1440

tacatggtac atttagatga aatgggaacc agatcctaaa tttttcaaat gtcattgcca   1500

atttatgtgt ataattccat cacttcctga tgagtaagtc tatttttgtt ctatatacat   1560

cataagttag tatatattct tatttacaga aacatgctca aatcacattc agaaagaaca   1620

aaaagtcatg ggaaattttt tattttacaa caaagccctg ctttctttct ggacgtattt   1680

tacatcatta gagagactat ctgcacatac atctaccata atctttttcc ttctttgcca   1740

actgttcagt gcacatgtgc tgcatcagaa atggcacctg gatgacagaa gctcaaagag   1800

tcacatatgt ctctaaaata gagttctttt cctcttgggc tgtctgaact ggtgtaaata   1860

gaagctcagt tgatcttggt tttaattaac ttattactct attaatataa ccttggaatt   1920

ctattctaat tatgttgttc tggctgcttg tagtatcagt tcgcccctct tgttagggag   1980

atatgtaaca atctgtcatt taattgagca gtctttttca cataacagta atagcaaaaa   2040

tcctacctac tcagaatcat cttcttaggt tgtctcctaa atctgaacaa tacagttgtt   2100

ttataaaatt acattttgtc tcttgagatt taatcaatta gaactcttta gggagaaaat   2160

aaataataga agaaaatata tgcctcatat ttcatatgta attatctgtt gatataattt   2220

ttcaatgtat tttgtatttg tgggagcata atgacctgta cattcaatat ttttactggt   2280

aattcaattt ttaaatatgt ttttacaatg cttgaacaca taaaccttag aaaactggaa   2340

aatacgtgtc cacagaaaga gttattagct actaccttat gtaaagatgc atagaaaatg   2400

aaattgttgg aaacatgtgc acaaagtgtt ttatattata tacattgtat ttatgaagaa   2460

taaataaaat attaagattg ttttcctgct agccaagaga agaaatcctt gggaaatatc   2520

taaggagtat atggggcttt ataagcactg tttctaaaag atattctctg gtacttttgc   2580

aaaaagtcga ctgtgactgt gtagcattat gttctgtaga atttttttca agtagcataa   2640

tttatttcat tggtgtgaaa acagccaaag gttccaatat cctcacaaat catttatgcc   2700

aaacatctga gggcaaaatt tagccggtgt tatttactag attcttccct ttgaactcac   2760

agactcaaga gacagaccaa gagttcttat atactcacca cagcggacca atccaagtgg   2820

catttttagg aaaggttgca gcatttaatg ccatgtggta tgtctgttcg tcaagtgggt   2880

ggcaagggaa tatccaagct ggcattttgg atatgatggg ccttttactt tcctgagtga   2940

catgccacat gtcaagaaat actgctcccc acccccccac tcccatcaca tttacgtgaa   3000

caattttcat ttagttattt cccgttccat atggtgttaa aacagtcgta ttaaataaag   3060

attatttcta gttttcagtg gtaatttaaa tgagaggata tgtaataatt gcttattaga   3120

tacttatcca aatgaaatat aacagagttt acagtactta aaatggctgg ttatggtctt   3180

ggaaatgttt gaaaattcat tatcctgaaa aaaactttac cattctgttt tacccttgag   3240

gtattttttg gggaaaaatg tttttgataa ctattaatct aaatatagta taattatagg   3300

caaatttcac tgcctagttt tattgatatc ctgagtctac agctagtcca ttcgtatgac   3360

tgattgattt atgatagctc cagagaacca taaatttcaa aggctaaact ctctgatttt   3420

agtaaatagt aggtaaagtg acacaatata tgtttacaca acactgtttt catgaaatgc   3480

aaactttgca aaactcacat taactgggaa gcagccaacc ctctgtagag aaatcccaga   3540

ttgggagtct ggtttgaatc tttgaagaca gaaaggtgat atccggcctg ctgttttaaa   3600

gggaccacac ttttgaatac ctactggtgt ttggcagaaa tctgagactg gcaccagaca   3660

caaattttag acatgggtat cttccctcca gtaattcact gctcagagta atttagaaga   3720

caaaaacaga aaaaattgta atgatttttt aagtgttaga atatgtttgt taacatactc   3780

tgcaaaataa atttcaacta atgcaataga cttaaaatat agcctatgga atactgtgat   3840

tgaagtttga aggcttgctg gttcttattt tgcatgcaag tttagacagg gtaaagaatg   3900

tataaattta tttgagatga gatacagtat tgtaaaaata taacctcatc tagaattgct   3960

tttaaaacaa gcaaaagcct attttagtac aaatgtaggg tgggtagttg ttttaaggta   4020

gcaaaatact tcaagatttt ctatcttttt aatttttcat gaagacagaa gaaatacttt   4080

caccccaacc aatgactgta agatcttgag agtatgttct tactcatttc tgtaattgca   4140

gtagtgtagt catctgcata taaatttaat aaatgcatgt taaaatttaa gttgatgcct   4200

tttagtcctc tcagagtctg tcacagtttc tttgtgtaaa tgataaaaaa gtttgaattt   4260

aatcaataaa acttaaaaat cacaatatc                                     4289


<210>  4943
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  4943

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  4944
<211>  3676
<212>  DNA
<213>  Homosapiens

<400>  4944
gtggacagca acatttccca caggacacga agtttgtcgg cccttgcctt ggcagagctg     60

agtaagaaaa atcaccaaga atattatttt tggtatttgg aattgaattt gccaggaatg    120

caagcactgc tacctaacta aagaccttgg ctttggaaac atcttacccc ttggcagctc    180

tccagagttt agacttggca gcatcaaaga cacaacgcaa gcaatatgaa acagaaaaac    240

aagttggttg gatagctgtc ctccatgcag tcattcatga tccaggctgt catcatcttc    300

atcactcatg ttcagagtta ccctagaggt catctccatt tcatccagat aaatgagtat    360

gcaaggaacg tttttatagg cattttggag atcaaagatg ggtagaaaag atgctgctac    420

tataaaactt cctgttgatc agtacagaaa acaaattggt aaacaggatt ataaaaaaac    480

taaacctatt ttacgagcaa ccaaattaaa agcagaagca aagaaaacag caataggcat    540

aaagactcac cacggatgtt gaccctgatc tggaccaaga tgaagattag ctaagcaaca    600

atcaatgcat gaaagagaaa taactttacg aaagcacctt ttgggaccaa aactttcaat    660

actgaaactg taacatcttt aattctttct gctaatattt tcagtttgca gacatatgat    720

ttttgatagt tgcataggat gtcaggaaaa gaaccttacc tagcaatgca gtatagtatg    780

tgctactgga tacttttata tatctttctg ctttgacagc caccctatac atggtacatt    840

tagatgaaat gggaaccaga tcctaaattt ttcaaatgtc attgccaatt tatgtgtata    900

attccatcac ttcctgatga gtaagtctat ttttgttcta tatacatcat aagttagtat    960

atattcttat ttacagaaac atgctcaaat cacattcaga aagaacaaaa agtcatggga   1020

aattttttat tttacaacaa agccctgctt tctttctgga cgtattttac atcattagag   1080

agactatctg cacatacatc taccataatc tttttccttc tttgccaact gttcagtgca   1140

catgtgctgc atcagaaatg gcacctggat gacagaagct caaagagtca catatgtctc   1200

taaaatagag ttcttttcct cttgggctgt ctgaactggt gtaaatagaa gctcagttga   1260

tcttggtttt aattaactta ttactctatt aatataacct tggaattcta ttctaattat   1320

gttgttctgg ctgcttgtag tatcagttcg cccctcttgt tagggagata tgtaacaatc   1380

tgtcatttaa ttgagcagtc tttttcacat aacagtaata gcaaaaatcc tacctactca   1440

gaatcatctt cttaggttgt ctcctaaatc tgaacaatac agttgtttta taaaattaca   1500

ttttgtctct tgagatttaa tcaattagaa ctctttaggg agaaaataaa taatagaaga   1560

aaatatatgc ctcatatttc atatgtaatt atctgttgat ataatttttc aatgtatttt   1620

gtatttgtgg gagcataatg acctgtacat tcaatatttt tactggtaat tcaattttta   1680

aatatgtttt tacaatgctt gaacacataa accttagaaa actggaaaat acgtgtccac   1740

agaaagagtt attagctact accttatgta aagatgcata gaaaatgaaa ttgttggaaa   1800

catgtgcaca aagtgtttta tattatatac attgtattta tgaagaataa ataaaatatt   1860

aagattgttt tcctgctagc caagagaaga aatccttggg aaatatctaa ggagtatatg   1920

gggctttata agcactgttt ctaaaagata ttctctggta cttttgcaaa aagtcgactg   1980

tgactgtgta gcattatgtt ctgtagaatt tttttcaagt agcataattt atttcattgg   2040

tgtgaaaaca gccaaaggtt ccaatatcct cacaaatcat ttatgccaaa catctgaggg   2100

caaaatttag ccggtgttat ttactagatt cttccctttg aactcacaga ctcaagagac   2160

agaccaagag ttcttatata ctcaccacag cggaccaatc caagtggcat ttttaggaaa   2220

ggttgcagca tttaatgcca tgtggtatgt ctgttcgtca agtgggtggc aagggaatat   2280

ccaagctggc attttggata tgatgggcct tttactttcc tgagtgacat gccacatgtc   2340

aagaaatact gctccccacc cccccactcc catcacattt acgtgaacaa ttttcattta   2400

gttatttccc gttccatatg gtgttaaaac agtcgtatta aataaagatt atttctagtt   2460

ttcagtggta atttaaatga gaggatatgt aataattgct tattagatac ttatccaaat   2520

gaaatataac agagtttaca gtacttaaaa tggctggtta tggtcttgga aatgtttgaa   2580

aattcattat cctgaaaaaa actttaccat tctgttttac ccttgaggta ttttttgggg   2640

aaaaatgttt ttgataacta ttaatctaaa tatagtataa ttataggcaa atttcactgc   2700

ctagttttat tgatatcctg agtctacagc tagtccattc gtatgactga ttgatttatg   2760

atagctccag agaaccataa atttcaaagg ctaaactctc tgattttagt aaatagtagg   2820

taaagtgaca caatatatgt ttacacaaca ctgttttcat gaaatgcaaa ctttgcaaaa   2880

ctcacattaa ctgggaagca gccaaccctc tgtagagaaa tcccagattg ggagtctggt   2940

ttgaatcttt gaagacagaa aggtgatatc cggcctgctg ttttaaaggg accacacttt   3000

tgaataccta ctggtgtttg gcagaaatct gagactggca ccagacacaa attttagaca   3060

tgggtatctt ccctccagta attcactgct cagagtaatt tagaagacaa aaacagaaaa   3120

aattgtaatg attttttaag tgttagaata tgtttgttaa catactctgc aaaataaatt   3180

tcaactaatg caatagactt aaaatatagc ctatggaata ctgtgattga agtttgaagg   3240

cttgctggtt cttattttgc atgcaagttt agacagggta aagaatgtat aaatttattt   3300

gagatgagat acagtattgt aaaaatataa cctcatctag aattgctttt aaaacaagca   3360

aaagcctatt ttagtacaaa tgtagggtgg gtagttgttt taaggtagca aaatacttca   3420

agattttcta tctttttaat ttttcatgaa gacagaagaa atactttcac cccaaccaat   3480

gactgtaaga tcttgagagt atgttcttac tcatttctgt aattgcagta gtgtagtcat   3540

ctgcatataa atttaataaa tgcatgttaa aatttaagtt gatgcctttt agtcctctca   3600

gagtctgtca cagtttcttt gtgtaaatga taaaaaagtt tgaatttaat caataaaact   3660

taaaaatcac aatatc                                                   3676


<210>  4945
<211>  54
<212>  PRT
<213>  Homosapiens

<400>  4945

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Thr His His Gly Cys 
    50                  


<210>  4946
<211>  3556
<212>  DNA
<213>  Homosapiens

<400>  4946
ggcttgtccc gcccctgccc ctgagtgaca gaaccgtgga cagcaacatt tcccacagga     60

cacgaagttt gtcggccctt gccttggcag agctgagtaa gaaaaatcac caagaatatt    120

atttttggta tttggaattg aatttgccag gaatgcaagc actgctacct aactaaagac    180

cttggctttg gaaacatctt accccttggc agctctccag agtttagact tggcagcatc    240

aaagacacaa cgcaagcagg cattttggag atcaaagatg ggtagaaaag atgctgctac    300

tataaaactt cctgttgatc agtacagaaa acaaattggt aaacaggatt ataaaaaaac    360

taaacctatt ttacgagcaa ccaaattaaa agcagaagca aagaaaacag caataggcat    420

aaagactcac cacggatgtt gaccctgatc tggaccaaga tgaagattag ctaagcaaca    480

atcaatgcat gaaagagaaa taactttacg aaagcacctt ttgggaccaa aactttcaat    540

actgaaactg taacatcttt aattctttct gctaatattt tcagtttgca gacatatgat    600

ttttgatagt tgcataggat gtcaggaaaa gaaccttacc tagcaatgca gtatagtatg    660

tgctactgga tacttttata tatctttctg ctttgacagc caccctatac atggtacatt    720

tagatgaaat gggaaccaga tcctaaattt ttcaaatgtc attgccaatt tatgtgtata    780

attccatcac ttcctgatga gtaagtctat ttttgttcta tatacatcat aagttagtat    840

atattcttat ttacagaaac atgctcaaat cacattcaga aagaacaaaa agtcatggga    900

aattttttat tttacaacaa agccctgctt tctttctgga cgtattttac atcattagag    960

agactatctg cacatacatc taccataatc tttttccttc tttgccaact gttcagtgca   1020

catgtgctgc atcagaaatg gcacctggat gacagaagct caaagagtca catatgtctc   1080

taaaatagag ttcttttcct cttgggctgt ctgaactggt gtaaatagaa gctcagttga   1140

tcttggtttt aattaactta ttactctatt aatataacct tggaattcta ttctaattat   1200

gttgttctgg ctgcttgtag tatcagttcg cccctcttgt tagggagata tgtaacaatc   1260

tgtcatttaa ttgagcagtc tttttcacat aacagtaata gcaaaaatcc tacctactca   1320

gaatcatctt cttaggttgt ctcctaaatc tgaacaatac agttgtttta taaaattaca   1380

ttttgtctct tgagatttaa tcaattagaa ctctttaggg agaaaataaa taatagaaga   1440

aaatatatgc ctcatatttc atatgtaatt atctgttgat ataatttttc aatgtatttt   1500

gtatttgtgg gagcataatg acctgtacat tcaatatttt tactggtaat tcaattttta   1560

aatatgtttt tacaatgctt gaacacataa accttagaaa actggaaaat acgtgtccac   1620

agaaagagtt attagctact accttatgta aagatgcata gaaaatgaaa ttgttggaaa   1680

catgtgcaca aagtgtttta tattatatac attgtattta tgaagaataa ataaaatatt   1740

aagattgttt tcctgctagc caagagaaga aatccttggg aaatatctaa ggagtatatg   1800

gggctttata agcactgttt ctaaaagata ttctctggta cttttgcaaa aagtcgactg   1860

tgactgtgta gcattatgtt ctgtagaatt tttttcaagt agcataattt atttcattgg   1920

tgtgaaaaca gccaaaggtt ccaatatcct cacaaatcat ttatgccaaa catctgaggg   1980

caaaatttag ccggtgttat ttactagatt cttccctttg aactcacaga ctcaagagac   2040

agaccaagag ttcttatata ctcaccacag cggaccaatc caagtggcat ttttaggaaa   2100

ggttgcagca tttaatgcca tgtggtatgt ctgttcgtca agtgggtggc aagggaatat   2160

ccaagctggc attttggata tgatgggcct tttactttcc tgagtgacat gccacatgtc   2220

aagaaatact gctccccacc cccccactcc catcacattt acgtgaacaa ttttcattta   2280

gttatttccc gttccatatg gtgttaaaac agtcgtatta aataaagatt atttctagtt   2340

ttcagtggta atttaaatga gaggatatgt aataattgct tattagatac ttatccaaat   2400

gaaatataac agagtttaca gtacttaaaa tggctggtta tggtcttgga aatgtttgaa   2460

aattcattat cctgaaaaaa actttaccat tctgttttac ccttgaggta ttttttgggg   2520

aaaaatgttt ttgataacta ttaatctaaa tatagtataa ttataggcaa atttcactgc   2580

ctagttttat tgatatcctg agtctacagc tagtccattc gtatgactga ttgatttatg   2640

atagctccag agaaccataa atttcaaagg ctaaactctc tgattttagt aaatagtagg   2700

taaagtgaca caatatatgt ttacacaaca ctgttttcat gaaatgcaaa ctttgcaaaa   2760

ctcacattaa ctgggaagca gccaaccctc tgtagagaaa tcccagattg ggagtctggt   2820

ttgaatcttt gaagacagaa aggtgatatc cggcctgctg ttttaaaggg accacacttt   2880

tgaataccta ctggtgtttg gcagaaatct gagactggca ccagacacaa attttagaca   2940

tgggtatctt ccctccagta attcactgct cagagtaatt tagaagacaa aaacagaaaa   3000

aattgtaatg attttttaag tgttagaata tgtttgttaa catactctgc aaaataaatt   3060

tcaactaatg caatagactt aaaatatagc ctatggaata ctgtgattga agtttgaagg   3120

cttgctggtt cttattttgc atgcaagttt agacagggta aagaatgtat aaatttattt   3180

gagatgagat acagtattgt aaaaatataa cctcatctag aattgctttt aaaacaagca   3240

aaagcctatt ttagtacaaa tgtagggtgg gtagttgttt taaggtagca aaatacttca   3300

agattttcta tctttttaat ttttcatgaa gacagaagaa atactttcac cccaaccaat   3360

gactgtaaga tcttgagagt atgttcttac tcatttctgt aattgcagta gtgtagtcat   3420

ctgcatataa atttaataaa tgcatgttaa aatttaagtt gatgcctttt agtcctctca   3480

gagtctgtca cagtttcttt gtgtaaatga taaaaaagtt tgaatttaat caataaaact   3540

taaaaatcac aatatc                                                   3556


<210>  4947
<211>  54
<212>  PRT
<213>  Homosapiens

<400>  4947

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Thr His His Gly Cys 
    50                  


<210>  4948
<211>  3408
<212>  DNA
<213>  Homosapiens

<400>  4948
aggggtgtgc ggctggcttg tcccgcccct gcccctgagt gacagaaccg tggacagcaa     60

catttcccac aggacacgaa gtttgtcggc ccttgccttg gcagagctga ggcattttgg    120

agatcaaaga tgggtagaaa agatgctgct actataaaac ttcctgttga tcagtacaga    180

aaacaaattg gtaaacagga ttataaaaaa actaaaccta ttttacgagc aaccaaatta    240

aaagcagaag caaagaaaac agcaataggc ataaagactc accacggatg ttgaccctga    300

tctggaccaa gatgaagatt agctaagcaa caatcaatgc atgaaagaga aataacttta    360

cgaaagcacc ttttgggacc aaaactttca atactgaaac tgtaacatct ttaattcttt    420

ctgctaatat tttcagtttg cagacatatg atttttgata gttgcatagg atgtcaggaa    480

aagaacctta cctagcaatg cagtatagta tgtgctactg gatactttta tatatctttc    540

tgctttgaca gccaccctat acatggtaca tttagatgaa atgggaacca gatcctaaat    600

ttttcaaatg tcattgccaa tttatgtgta taattccatc acttcctgat gagtaagtct    660

atttttgttc tatatacatc ataagttagt atatattctt atttacagaa acatgctcaa    720

atcacattca gaaagaacaa aaagtcatgg gaaatttttt attttacaac aaagccctgc    780

tttctttctg gacgtatttt acatcattag agagactatc tgcacataca tctaccataa    840

tctttttcct tctttgccaa ctgttcagtg cacatgtgct gcatcagaaa tggcacctgg    900

atgacagaag ctcaaagagt cacatatgtc tctaaaatag agttcttttc ctcttgggct    960

gtctgaactg gtgtaaatag aagctcagtt gatcttggtt ttaattaact tattactcta   1020

ttaatataac cttggaattc tattctaatt atgttgttct ggctgcttgt agtatcagtt   1080

cgcccctctt gttagggaga tatgtaacaa tctgtcattt aattgagcag tctttttcac   1140

ataacagtaa tagcaaaaat cctacctact cagaatcatc ttcttaggtt gtctcctaaa   1200

tctgaacaat acagttgttt tataaaatta cattttgtct cttgagattt aatcaattag   1260

aactctttag ggagaaaata aataatagaa gaaaatatat gcctcatatt tcatatgtaa   1320

ttatctgttg atataatttt tcaatgtatt ttgtatttgt gggagcataa tgacctgtac   1380

attcaatatt tttactggta attcaatttt taaatatgtt tttacaatgc ttgaacacat   1440

aaaccttaga aaactggaaa atacgtgtcc acagaaagag ttattagcta ctaccttatg   1500

taaagatgca tagaaaatga aattgttgga aacatgtgca caaagtgttt tatattatat   1560

acattgtatt tatgaagaat aaataaaata ttaagattgt tttcctgcta gccaagagaa   1620

gaaatccttg ggaaatatct aaggagtata tggggcttta taagcactgt ttctaaaaga   1680

tattctctgg tacttttgca aaaagtcgac tgtgactgtg tagcattatg ttctgtagaa   1740

tttttttcaa gtagcataat ttatttcatt ggtgtgaaaa cagccaaagg ttccaatatc   1800

ctcacaaatc atttatgcca aacatctgag ggcaaaattt agccggtgtt atttactaga   1860

ttcttccctt tgaactcaca gactcaagag acagaccaag agttcttata tactcaccac   1920

agcggaccaa tccaagtggc atttttagga aaggttgcag catttaatgc catgtggtat   1980

gtctgttcgt caagtgggtg gcaagggaat atccaagctg gcattttgga tatgatgggc   2040

cttttacttt cctgagtgac atgccacatg tcaagaaata ctgctcccca cccccccact   2100

cccatcacat ttacgtgaac aattttcatt tagttatttc ccgttccata tggtgttaaa   2160

acagtcgtat taaataaaga ttatttctag ttttcagtgg taatttaaat gagaggatat   2220

gtaataattg cttattagat acttatccaa atgaaatata acagagttta cagtacttaa   2280

aatggctggt tatggtcttg gaaatgtttg aaaattcatt atcctgaaaa aaactttacc   2340

attctgtttt acccttgagg tattttttgg ggaaaaatgt ttttgataac tattaatcta   2400

aatatagtat aattataggc aaatttcact gcctagtttt attgatatcc tgagtctaca   2460

gctagtccat tcgtatgact gattgattta tgatagctcc agagaaccat aaatttcaaa   2520

ggctaaactc tctgatttta gtaaatagta ggtaaagtga cacaatatat gtttacacaa   2580

cactgttttc atgaaatgca aactttgcaa aactcacatt aactgggaag cagccaaccc   2640

tctgtagaga aatcccagat tgggagtctg gtttgaatct ttgaagacag aaaggtgata   2700

tccggcctgc tgttttaaag ggaccacact tttgaatacc tactggtgtt tggcagaaat   2760

ctgagactgg caccagacac aaattttaga catgggtatc ttccctccag taattcactg   2820

ctcagagtaa tttagaagac aaaaacagaa aaaattgtaa tgatttttta agtgttagaa   2880

tatgtttgtt aacatactct gcaaaataaa tttcaactaa tgcaatagac ttaaaatata   2940

gcctatggaa tactgtgatt gaagtttgaa ggcttgctgg ttcttatttt gcatgcaagt   3000

ttagacaggg taaagaatgt ataaatttat ttgagatgag atacagtatt gtaaaaatat   3060

aacctcatct agaattgctt ttaaaacaag caaaagccta ttttagtaca aatgtagggt   3120

gggtagttgt tttaaggtag caaaatactt caagattttc tatcttttta atttttcatg   3180

aagacagaag aaatactttc accccaacca atgactgtaa gatcttgaga gtatgttctt   3240

actcatttct gtaattgcag tagtgtagtc atctgcatat aaatttaata aatgcatgtt   3300

aaaatttaag ttgatgcctt ttagtcctct cagagtctgt cacagtttct ttgtgtaaat   3360

gataaaaaag tttgaattta atcaataaaa cttaaaaatc acaatatc                3408


<210>  4949
<211>  54
<212>  PRT
<213>  Homosapiens

<400>  4949

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Thr His His Gly Cys 
    50                  


<210>  4950
<211>  3622
<212>  DNA
<213>  Homosapiens

<400>  4950
ctggcttgtc ccgcccctgc ccctgagtga cagaaccgtg gacagcaaca tttcccacag     60

gacacgaagt ttgtcggccc ttgccttggc agagctgagc aatatgaaac agaaaaacaa    120

gttggttgga tagctgtcct ccatgcagtc attcatgatc caggctgtca tcatcttcat    180

cactcatgtt cagagttacc ctagaggtca tctccatttc atccagataa atgagtatgc    240

aaggaacgtt tttataggca ttttggagat caaagatggg tagaaaagat gctgctacta    300

taaaacttcc tgttgatcag tacagaaaac aaattggtaa acaggattat aaaaaaacta    360

aacctatttt acgagcaacc aaattaaaag cagaagcaaa gaaaacagca ataggcataa    420

aggaagttgg ccttgtactt gcagctatat tggcactact actggctttc tatgctttct    480

tttatctcag actcaccacg gatgttgacc ctgatctgga ccaagatgaa gattagctaa    540

gcaacaatca atgcatgaaa gagaaataac tttacgaaag caccttttgg gaccaaaact    600

ttcaatactg aaactgtaac atctttaatt ctttctgcta atattttcag tttgcagaca    660

tatgattttt gatagttgca taggatgtca ggaaaagaac cttacctagc aatgcagtat    720

agtatgtgct actggatact tttatatatc tttctgcttt gacagccacc ctatacatgg    780

tacatttaga tgaaatggga accagatcct aaatttttca aatgtcattg ccaatttatg    840

tgtataattc catcacttcc tgatgagtaa gtctattttt gttctatata catcataagt    900

tagtatatat tcttatttac agaaacatgc tcaaatcaca ttcagaaaga acaaaaagtc    960

atgggaaatt ttttatttta caacaaagcc ctgctttctt tctggacgta ttttacatca   1020

ttagagagac tatctgcaca tacatctacc ataatctttt tccttctttg ccaactgttc   1080

agtgcacatg tgctgcatca gaaatggcac ctggatgaca gaagctcaaa gagtcacata   1140

tgtctctaaa atagagttct tttcctcttg ggctgtctga actggtgtaa atagaagctc   1200

agttgatctt ggttttaatt aacttattac tctattaata taaccttgga attctattct   1260

aattatgttg ttctggctgc ttgtagtatc agttcgcccc tcttgttagg gagatatgta   1320

acaatctgtc atttaattga gcagtctttt tcacataaca gtaatagcaa aaatcctacc   1380

tactcagaat catcttctta ggttgtctcc taaatctgaa caatacagtt gttttataaa   1440

attacatttt gtctcttgag atttaatcaa ttagaactct ttagggagaa aataaataat   1500

agaagaaaat atatgcctca tatttcatat gtaattatct gttgatataa tttttcaatg   1560

tattttgtat ttgtgggagc ataatgacct gtacattcaa tatttttact ggtaattcaa   1620

tttttaaata tgtttttaca atgcttgaac acataaacct tagaaaactg gaaaatacgt   1680

gtccacagaa agagttatta gctactacct tatgtaaaga tgcatagaaa atgaaattgt   1740

tggaaacatg tgcacaaagt gttttatatt atatacattg tatttatgaa gaataaataa   1800

aatattaaga ttgttttcct gctagccaag agaagaaatc cttgggaaat atctaaggag   1860

tatatggggc tttataagca ctgtttctaa aagatattct ctggtacttt tgcaaaaagt   1920

cgactgtgac tgtgtagcat tatgttctgt agaatttttt tcaagtagca taatttattt   1980

cattggtgtg aaaacagcca aaggttccaa tatcctcaca aatcatttat gccaaacatc   2040

tgagggcaaa atttagccgg tgttatttac tagattcttc cctttgaact cacagactca   2100

agagacagac caagagttct tatatactca ccacagcgga ccaatccaag tggcattttt   2160

aggaaaggtt gcagcattta atgccatgtg gtatgtctgt tcgtcaagtg ggtggcaagg   2220

gaatatccaa gctggcattt tggatatgat gggcctttta ctttcctgag tgacatgcca   2280

catgtcaaga aatactgctc cccacccccc cactcccatc acatttacgt gaacaatttt   2340

catttagtta tttcccgttc catatggtgt taaaacagtc gtattaaata aagattattt   2400

ctagttttca gtggtaattt aaatgagagg atatgtaata attgcttatt agatacttat   2460

ccaaatgaaa tataacagag tttacagtac ttaaaatggc tggttatggt cttggaaatg   2520

tttgaaaatt cattatcctg aaaaaaactt taccattctg ttttaccctt gaggtatttt   2580

ttggggaaaa atgtttttga taactattaa tctaaatata gtataattat aggcaaattt   2640

cactgcctag ttttattgat atcctgagtc tacagctagt ccattcgtat gactgattga   2700

tttatgatag ctccagagaa ccataaattt caaaggctaa actctctgat tttagtaaat   2760

agtaggtaaa gtgacacaat atatgtttac acaacactgt tttcatgaaa tgcaaacttt   2820

gcaaaactca cattaactgg gaagcagcca accctctgta gagaaatccc agattgggag   2880

tctggtttga atctttgaag acagaaaggt gatatccggc ctgctgtttt aaagggacca   2940

cacttttgaa tacctactgg tgtttggcag aaatctgaga ctggcaccag acacaaattt   3000

tagacatggg tatcttccct ccagtaattc actgctcaga gtaatttaga agacaaaaac   3060

agaaaaaatt gtaatgattt tttaagtgtt agaatatgtt tgttaacata ctctgcaaaa   3120

taaatttcaa ctaatgcaat agacttaaaa tatagcctat ggaatactgt gattgaagtt   3180

tgaaggcttg ctggttctta ttttgcatgc aagtttagac agggtaaaga atgtataaat   3240

ttatttgaga tgagatacag tattgtaaaa atataacctc atctagaatt gcttttaaaa   3300

caagcaaaag cctattttag tacaaatgta gggtgggtag ttgttttaag gtagcaaaat   3360

acttcaagat tttctatctt tttaattttt catgaagaca gaagaaatac tttcacccca   3420

accaatgact gtaagatctt gagagtatgt tcttactcat ttctgtaatt gcagtagtgt   3480

agtcatctgc atataaattt aataaatgca tgttaaaatt taagttgatg ccttttagtc   3540

ctctcagagt ctgtcacagt ttctttgtgt aaatgataaa aaagtttgaa tttaatcaat   3600

aaaacttaaa aatcacaata tc                                            3622


<210>  4951
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  4951

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  4952
<211>  3586
<212>  DNA
<213>  Homosapiens

<400>  4952
gcaattctgg cctctccagc ctcttgcctt tcttctgagg ggagcctttt atcctgctgt     60

aagaaaaatc accaagaata ttatttttgg tatttggaat tgaatttgcc aggaatgcaa    120

gcactgctac ctaactaaag accttggctt tggaaacatc ttaccccttg gcagctctcc    180

agagtttaga cttggcagca tcaaagacac aacgcaagca ggcattttgg agatcaaaga    240

tgggtagaaa agatgctgct actataaaac ttcctgttga tcagtacaga aaacaaattg    300

gtaaacagga ttataaaaaa actaaaccta ttttacgagc aaccaaatta aaagcagaag    360

caaagaaaac agcaataggc ataaaggaag ttggccttgt acttgcagct atattggcac    420

tactactggc tttctatgct ttcttttatc tcagactcac cacggatgtt gaccctgatc    480

tggaccaaga tgaagattag ctaagcaaca atcaatgcat gaaagagaaa taactttacg    540

aaagcacctt ttgggaccaa aactttcaat actgaaactg taacatcttt aattctttct    600

gctaatattt tcagtttgca gacatatgat ttttgatagt tgcataggat gtcaggaaaa    660

gaaccttacc tagcaatgca gtatagtatg tgctactgga tacttttata tatctttctg    720

ctttgacagc caccctatac atggtacatt tagatgaaat gggaaccaga tcctaaattt    780

ttcaaatgtc attgccaatt tatgtgtata attccatcac ttcctgatga gtaagtctat    840

ttttgttcta tatacatcat aagttagtat atattcttat ttacagaaac atgctcaaat    900

cacattcaga aagaacaaaa agtcatggga aattttttat tttacaacaa agccctgctt    960

tctttctgga cgtattttac atcattagag agactatctg cacatacatc taccataatc   1020

tttttccttc tttgccaact gttcagtgca catgtgctgc atcagaaatg gcacctggat   1080

gacagaagct caaagagtca catatgtctc taaaatagag ttcttttcct cttgggctgt   1140

ctgaactggt gtaaatagaa gctcagttga tcttggtttt aattaactta ttactctatt   1200

aatataacct tggaattcta ttctaattat gttgttctgg ctgcttgtag tatcagttcg   1260

cccctcttgt tagggagata tgtaacaatc tgtcatttaa ttgagcagtc tttttcacat   1320

aacagtaata gcaaaaatcc tacctactca gaatcatctt cttaggttgt ctcctaaatc   1380

tgaacaatac agttgtttta taaaattaca ttttgtctct tgagatttaa tcaattagaa   1440

ctctttaggg agaaaataaa taatagaaga aaatatatgc ctcatatttc atatgtaatt   1500

atctgttgat ataatttttc aatgtatttt gtatttgtgg gagcataatg acctgtacat   1560

tcaatatttt tactggtaat tcaattttta aatatgtttt tacaatgctt gaacacataa   1620

accttagaaa actggaaaat acgtgtccac agaaagagtt attagctact accttatgta   1680

aagatgcata gaaaatgaaa ttgttggaaa catgtgcaca aagtgtttta tattatatac   1740

attgtattta tgaagaataa ataaaatatt aagattgttt tcctgctagc caagagaaga   1800

aatccttggg aaatatctaa ggagtatatg gggctttata agcactgttt ctaaaagata   1860

ttctctggta cttttgcaaa aagtcgactg tgactgtgta gcattatgtt ctgtagaatt   1920

tttttcaagt agcataattt atttcattgg tgtgaaaaca gccaaaggtt ccaatatcct   1980

cacaaatcat ttatgccaaa catctgaggg caaaatttag ccggtgttat ttactagatt   2040

cttccctttg aactcacaga ctcaagagac agaccaagag ttcttatata ctcaccacag   2100

cggaccaatc caagtggcat ttttaggaaa ggttgcagca tttaatgcca tgtggtatgt   2160

ctgttcgtca agtgggtggc aagggaatat ccaagctggc attttggata tgatgggcct   2220

tttactttcc tgagtgacat gccacatgtc aagaaatact gctccccacc cccccactcc   2280

catcacattt acgtgaacaa ttttcattta gttatttccc gttccatatg gtgttaaaac   2340

agtcgtatta aataaagatt atttctagtt ttcagtggta atttaaatga gaggatatgt   2400

aataattgct tattagatac ttatccaaat gaaatataac agagtttaca gtacttaaaa   2460

tggctggtta tggtcttgga aatgtttgaa aattcattat cctgaaaaaa actttaccat   2520

tctgttttac ccttgaggta ttttttgggg aaaaatgttt ttgataacta ttaatctaaa   2580

tatagtataa ttataggcaa atttcactgc ctagttttat tgatatcctg agtctacagc   2640

tagtccattc gtatgactga ttgatttatg atagctccag agaaccataa atttcaaagg   2700

ctaaactctc tgattttagt aaatagtagg taaagtgaca caatatatgt ttacacaaca   2760

ctgttttcat gaaatgcaaa ctttgcaaaa ctcacattaa ctgggaagca gccaaccctc   2820

tgtagagaaa tcccagattg ggagtctggt ttgaatcttt gaagacagaa aggtgatatc   2880

cggcctgctg ttttaaaggg accacacttt tgaataccta ctggtgtttg gcagaaatct   2940

gagactggca ccagacacaa attttagaca tgggtatctt ccctccagta attcactgct   3000

cagagtaatt tagaagacaa aaacagaaaa aattgtaatg attttttaag tgttagaata   3060

tgtttgttaa catactctgc aaaataaatt tcaactaatg caatagactt aaaatatagc   3120

ctatggaata ctgtgattga agtttgaagg cttgctggtt cttattttgc atgcaagttt   3180

agacagggta aagaatgtat aaatttattt gagatgagat acagtattgt aaaaatataa   3240

cctcatctag aattgctttt aaaacaagca aaagcctatt ttagtacaaa tgtagggtgg   3300

gtagttgttt taaggtagca aaatacttca agattttcta tctttttaat ttttcatgaa   3360

gacagaagaa atactttcac cccaaccaat gactgtaaga tcttgagagt atgttcttac   3420

tcatttctgt aattgcagta gtgtagtcat ctgcatataa atttaataaa tgcatgttaa   3480

aatttaagtt gatgcctttt agtcctctca gagtctgtca cagtttcttt gtgtaaatga   3540

taaaaaagtt tgaatttaat caataaaact taaaaatcac aatatc                  3586


<210>  4953
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  4953

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  4954
<211>  4070
<212>  DNA
<213>  Homosapiens

<400>  4954
attaactaaa caagtcacag tctttatttt taatttctac agtcacctcg tgagacaggt     60

attagaactc cggagtggca tcaaaatgag ggaaaggcct cagggccagc gcctttgcgt    120

cctggaccgg cgtacagacg ggagaaaggc cgaccaatcc gagagcaggc tgaggcctgg    180

tcccgcccct gggggcagag cctcgcctct tttccgcctc accctttggg agtaggggtg    240

tgcggctggc ttgtcccgcc cctgcccctg agtgacagaa ccgtggacag caacatttcc    300

cacaggacac gaagtttgtc ggcccttgcc ttggcagagc tgaggtgtgt gtccggcgag    360

tgcgagggga ttggggagac cctgcccggg aagctcgggg tccgggaatg aaagcgggcg    420

cacctcttta gcgagcccta aagcgtttgg gagacgatcg ttccgtccct gggagcggca    480

cttggtgggg ctgggcggag ggaggctctg caagagaaac ccggagtccg ggaaacccag    540

tagtaagaaa aatcaccaag aatattattt ttggtatttg gaattgaatt tgccaggaat    600

gcaagcactg ctacctaact aaagaccttg gctttggaaa catcttaccc cttggcagct    660

ctccagagtt tagacttggc agcatcaaag acacaacgca agcaggcatt ttggagatca    720

aagatgggta gaaaagatgc tgctactata aaacttcctg ttgatcagta cagaaaacaa    780

attggtaaac aggattataa aaaaactaaa cctattttac gagcaaccaa attaaaagca    840

gaagcaaaga aaacagcaat aggcataaag gaagttggcc ttgtacttgc agctatattg    900

gcactactac tggctttcta tgctttcttt tatctcagac tcaccacgga tgttgaccct    960

gatctggacc aagatgaaga ttagctaagc aacaatcaat gcatgaaaga gaaataactt   1020

tacgaaagca ccttttggga ccaaaacttt caatactgaa actgtaacat ctttaattct   1080

ttctgctaat attttcagtt tgcagacata tgatttttga tagttgcata ggatgtcagg   1140

aaaagaacct tacctagcaa tgcagtatag tatgtgctac tggatacttt tatatatctt   1200

tctgctttga cagccaccct atacatggta catttagatg aaatgggaac cagatcctaa   1260

atttttcaaa tgtcattgcc aatttatgtg tataattcca tcacttcctg atgagtaagt   1320

ctatttttgt tctatataca tcataagtta gtatatattc ttatttacag aaacatgctc   1380

aaatcacatt cagaaagaac aaaaagtcat gggaaatttt ttattttaca acaaagccct   1440

gctttctttc tggacgtatt ttacatcatt agagagacta tctgcacata catctaccat   1500

aatctttttc cttctttgcc aactgttcag tgcacatgtg ctgcatcaga aatggcacct   1560

ggatgacaga agctcaaaga gtcacatatg tctctaaaat agagttcttt tcctcttggg   1620

ctgtctgaac tggtgtaaat agaagctcag ttgatcttgg ttttaattaa cttattactc   1680

tattaatata accttggaat tctattctaa ttatgttgtt ctggctgctt gtagtatcag   1740

ttcgcccctc ttgttaggga gatatgtaac aatctgtcat ttaattgagc agtctttttc   1800

acataacagt aatagcaaaa atcctaccta ctcagaatca tcttcttagg ttgtctccta   1860

aatctgaaca atacagttgt tttataaaat tacattttgt ctcttgagat ttaatcaatt   1920

agaactcttt agggagaaaa taaataatag aagaaaatat atgcctcata tttcatatgt   1980

aattatctgt tgatataatt tttcaatgta ttttgtattt gtgggagcat aatgacctgt   2040

acattcaata tttttactgg taattcaatt tttaaatatg tttttacaat gcttgaacac   2100

ataaacctta gaaaactgga aaatacgtgt ccacagaaag agttattagc tactacctta   2160

tgtaaagatg catagaaaat gaaattgttg gaaacatgtg cacaaagtgt tttatattat   2220

atacattgta tttatgaaga ataaataaaa tattaagatt gttttcctgc tagccaagag   2280

aagaaatcct tgggaaatat ctaaggagta tatggggctt tataagcact gtttctaaaa   2340

gatattctct ggtacttttg caaaaagtcg actgtgactg tgtagcatta tgttctgtag   2400

aatttttttc aagtagcata atttatttca ttggtgtgaa aacagccaaa ggttccaata   2460

tcctcacaaa tcatttatgc caaacatctg agggcaaaat ttagccggtg ttatttacta   2520

gattcttccc tttgaactca cagactcaag agacagacca agagttctta tatactcacc   2580

acagcggacc aatccaagtg gcatttttag gaaaggttgc agcatttaat gccatgtggt   2640

atgtctgttc gtcaagtggg tggcaaggga atatccaagc tggcattttg gatatgatgg   2700

gccttttact ttcctgagtg acatgccaca tgtcaagaaa tactgctccc caccccccca   2760

ctcccatcac atttacgtga acaattttca tttagttatt tcccgttcca tatggtgtta   2820

aaacagtcgt attaaataaa gattatttct agttttcagt ggtaatttaa atgagaggat   2880

atgtaataat tgcttattag atacttatcc aaatgaaata taacagagtt tacagtactt   2940

aaaatggctg gttatggtct tggaaatgtt tgaaaattca ttatcctgaa aaaaacttta   3000

ccattctgtt ttacccttga ggtatttttt ggggaaaaat gtttttgata actattaatc   3060

taaatatagt ataattatag gcaaatttca ctgcctagtt ttattgatat cctgagtcta   3120

cagctagtcc attcgtatga ctgattgatt tatgatagct ccagagaacc ataaatttca   3180

aaggctaaac tctctgattt tagtaaatag taggtaaagt gacacaatat atgtttacac   3240

aacactgttt tcatgaaatg caaactttgc aaaactcaca ttaactggga agcagccaac   3300

cctctgtaga gaaatcccag attgggagtc tggtttgaat ctttgaagac agaaaggtga   3360

tatccggcct gctgttttaa agggaccaca cttttgaata cctactggtg tttggcagaa   3420

atctgagact ggcaccagac acaaatttta gacatgggta tcttccctcc agtaattcac   3480

tgctcagagt aatttagaag acaaaaacag aaaaaattgt aatgattttt taagtgttag   3540

aatatgtttg ttaacatact ctgcaaaata aatttcaact aatgcaatag acttaaaata   3600

tagcctatgg aatactgtga ttgaagtttg aaggcttgct ggttcttatt ttgcatgcaa   3660

gtttagacag ggtaaagaat gtataaattt atttgagatg agatacagta ttgtaaaaat   3720

ataacctcat ctagaattgc ttttaaaaca agcaaaagcc tattttagta caaatgtagg   3780

gtgggtagtt gttttaaggt agcaaaatac ttcaagattt tctatctttt taatttttca   3840

tgaagacaga agaaatactt tcaccccaac caatgactgt aagatcttga gagtatgttc   3900

ttactcattt ctgtaattgc agtagtgtag tcatctgcat ataaatttaa taaatgcatg   3960

ttaaaattta agttgatgcc ttttagtcct ctcagagtct gtcacagttt ctttgtgtaa   4020

atgataaaaa agtttgaatt taatcaataa aacttaaaaa tcacaatatc              4070


<210>  4955
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  4955

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  4956
<211>  3768
<212>  DNA
<213>  Homosapiens

<400>  4956
cccctgcccc tgagtgacag aaccgtggac agcaacattt cccacaggac acgaagtttg     60

tcggcccttg ccttggcaga gctgagtaag aaaaatcacc aagaatatta tttttggtat    120

ttggaattga atttgccagg aatgcaagca ctgctaccta actaaagacc ttggctttgg    180

aaacatctta ccccttggca gctctccaga gtttagactt ggcagcatca aagacacaac    240

gcaagcaata tgaaacagaa aaacaagttg gttggatagc tgtcctccat gcagtcattc    300

atgatccagg ctgtcatcat cttcatcact catgttcaga gttaccctag aggtcatctc    360

catttcatcc agataaatga gtatgcaagg aacgttttta taggcatttt ggagatcaaa    420

gatgggtaga aaagatgctg ctactataaa acttcctgtt gatcagtaca gaaaacaaat    480

tggtaaacag gattataaaa aaactaaacc tattttacga gcaaccaaat taaaagcaga    540

agcaaagaaa acagcaatag gcataaagga agttggcctt gtacttgcag ctatattggc    600

actactactg gctttctatg ctttctttta tctcagactc accacggatg ttgaccctga    660

tctggaccaa gatgaagatt agctaagcaa caatcaatgc atgaaagaga aataacttta    720

cgaaagcacc ttttgggacc aaaactttca atactgaaac tgtaacatct ttaattcttt    780

ctgctaatat tttcagtttg cagacatatg atttttgata gttgcatagg atgtcaggaa    840

aagaacctta cctagcaatg cagtatagta tgtgctactg gatactttta tatatctttc    900

tgctttgaca gccaccctat acatggtaca tttagatgaa atgggaacca gatcctaaat    960

ttttcaaatg tcattgccaa tttatgtgta taattccatc acttcctgat gagtaagtct   1020

atttttgttc tatatacatc ataagttagt atatattctt atttacagaa acatgctcaa   1080

atcacattca gaaagaacaa aaagtcatgg gaaatttttt attttacaac aaagccctgc   1140

tttctttctg gacgtatttt acatcattag agagactatc tgcacataca tctaccataa   1200

tctttttcct tctttgccaa ctgttcagtg cacatgtgct gcatcagaaa tggcacctgg   1260

atgacagaag ctcaaagagt cacatatgtc tctaaaatag agttcttttc ctcttgggct   1320

gtctgaactg gtgtaaatag aagctcagtt gatcttggtt ttaattaact tattactcta   1380

ttaatataac cttggaattc tattctaatt atgttgttct ggctgcttgt agtatcagtt   1440

cgcccctctt gttagggaga tatgtaacaa tctgtcattt aattgagcag tctttttcac   1500

ataacagtaa tagcaaaaat cctacctact cagaatcatc ttcttaggtt gtctcctaaa   1560

tctgaacaat acagttgttt tataaaatta cattttgtct cttgagattt aatcaattag   1620

aactctttag ggagaaaata aataatagaa gaaaatatat gcctcatatt tcatatgtaa   1680

ttatctgttg atataatttt tcaatgtatt ttgtatttgt gggagcataa tgacctgtac   1740

attcaatatt tttactggta attcaatttt taaatatgtt tttacaatgc ttgaacacat   1800

aaaccttaga aaactggaaa atacgtgtcc acagaaagag ttattagcta ctaccttatg   1860

taaagatgca tagaaaatga aattgttgga aacatgtgca caaagtgttt tatattatat   1920

acattgtatt tatgaagaat aaataaaata ttaagattgt tttcctgcta gccaagagaa   1980

gaaatccttg ggaaatatct aaggagtata tggggcttta taagcactgt ttctaaaaga   2040

tattctctgg tacttttgca aaaagtcgac tgtgactgtg tagcattatg ttctgtagaa   2100

tttttttcaa gtagcataat ttatttcatt ggtgtgaaaa cagccaaagg ttccaatatc   2160

ctcacaaatc atttatgcca aacatctgag ggcaaaattt agccggtgtt atttactaga   2220

ttcttccctt tgaactcaca gactcaagag acagaccaag agttcttata tactcaccac   2280

agcggaccaa tccaagtggc atttttagga aaggttgcag catttaatgc catgtggtat   2340

gtctgttcgt caagtgggtg gcaagggaat atccaagctg gcattttgga tatgatgggc   2400

cttttacttt cctgagtgac atgccacatg tcaagaaata ctgctcccca cccccccact   2460

cccatcacat ttacgtgaac aattttcatt tagttatttc ccgttccata tggtgttaaa   2520

acagtcgtat taaataaaga ttatttctag ttttcagtgg taatttaaat gagaggatat   2580

gtaataattg cttattagat acttatccaa atgaaatata acagagttta cagtacttaa   2640

aatggctggt tatggtcttg gaaatgtttg aaaattcatt atcctgaaaa aaactttacc   2700

attctgtttt acccttgagg tattttttgg ggaaaaatgt ttttgataac tattaatcta   2760

aatatagtat aattataggc aaatttcact gcctagtttt attgatatcc tgagtctaca   2820

gctagtccat tcgtatgact gattgattta tgatagctcc agagaaccat aaatttcaaa   2880

ggctaaactc tctgatttta gtaaatagta ggtaaagtga cacaatatat gtttacacaa   2940

cactgttttc atgaaatgca aactttgcaa aactcacatt aactgggaag cagccaaccc   3000

tctgtagaga aatcccagat tgggagtctg gtttgaatct ttgaagacag aaaggtgata   3060

tccggcctgc tgttttaaag ggaccacact tttgaatacc tactggtgtt tggcagaaat   3120

ctgagactgg caccagacac aaattttaga catgggtatc ttccctccag taattcactg   3180

ctcagagtaa tttagaagac aaaaacagaa aaaattgtaa tgatttttta agtgttagaa   3240

tatgtttgtt aacatactct gcaaaataaa tttcaactaa tgcaatagac ttaaaatata   3300

gcctatggaa tactgtgatt gaagtttgaa ggcttgctgg ttcttatttt gcatgcaagt   3360

ttagacaggg taaagaatgt ataaatttat ttgagatgag atacagtatt gtaaaaatat   3420

aacctcatct agaattgctt ttaaaacaag caaaagccta ttttagtaca aatgtagggt   3480

gggtagttgt tttaaggtag caaaatactt caagattttc tatcttttta atttttcatg   3540

aagacagaag aaatactttc accccaacca atgactgtaa gatcttgaga gtatgttctt   3600

actcatttct gtaattgcag tagtgtagtc atctgcatat aaatttaata aatgcatgtt   3660

aaaatttaag ttgatgcctt ttagtcctct cagagtctgt cacagtttct ttgtgtaaat   3720

gataaaaaag tttgaattta atcaataaaa cttaaaaatc acaatatc                3768


<210>  4957
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  4957

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  4958
<211>  3656
<212>  DNA
<213>  Homosapiens

<400>  4958
tccgcctcac cctttgggag taggggtgtg cggctggctt gtcccgcccc tgcccctgag     60

tgacagaacc gtggacagca acatttccca caggacacga agtttgtcgg cccttgcctt    120

ggcagagctg agtaagaaaa atcaccaaga atattatttt tggtatttgg aattgaattt    180

gccaggaatg caagcactgc tacctaacta aagaccttgg ctttggaaac atcttacccc    240

ttggcagctc tccagagttt agacttggca gcatcaaaga cacaacgcaa ggcattttgg    300

agatcaaaga tgggtagaaa agatgctgct actataaaac ttcctgttga tcagtacaga    360

aaacaaattg gtaaacagga ttataaaaaa actaaaccta ttttacgagc aaccaaatta    420

aaagcagaag caaagaaaac agcaataggc ataaaggaag ttggccttgt acttgcagct    480

atattggcac tactactggc tttctatgct ttcttttatc tcagactcac cacggatgtt    540

gaccctgatc tggaccaaga tgaagattag ctaagcaaca atcaatgcat gaaagagaaa    600

taactttacg aaagcacctt ttgggaccaa aactttcaat actgaaactg taacatcttt    660

aattctttct gctaatattt tcagtttgca gacatatgat ttttgatagt tgcataggat    720

gtcaggaaaa gaaccttacc tagcaatgca gtatagtatg tgctactgga tacttttata    780

tatctttctg ctttgacagc caccctatac atggtacatt tagatgaaat gggaaccaga    840

tcctaaattt ttcaaatgtc attgccaatt tatgtgtata attccatcac ttcctgatga    900

gtaagtctat ttttgttcta tatacatcat aagttagtat atattcttat ttacagaaac    960

atgctcaaat cacattcaga aagaacaaaa agtcatggga aattttttat tttacaacaa   1020

agccctgctt tctttctgga cgtattttac atcattagag agactatctg cacatacatc   1080

taccataatc tttttccttc tttgccaact gttcagtgca catgtgctgc atcagaaatg   1140

gcacctggat gacagaagct caaagagtca catatgtctc taaaatagag ttcttttcct   1200

cttgggctgt ctgaactggt gtaaatagaa gctcagttga tcttggtttt aattaactta   1260

ttactctatt aatataacct tggaattcta ttctaattat gttgttctgg ctgcttgtag   1320

tatcagttcg cccctcttgt tagggagata tgtaacaatc tgtcatttaa ttgagcagtc   1380

tttttcacat aacagtaata gcaaaaatcc tacctactca gaatcatctt cttaggttgt   1440

ctcctaaatc tgaacaatac agttgtttta taaaattaca ttttgtctct tgagatttaa   1500

tcaattagaa ctctttaggg agaaaataaa taatagaaga aaatatatgc ctcatatttc   1560

atatgtaatt atctgttgat ataatttttc aatgtatttt gtatttgtgg gagcataatg   1620

acctgtacat tcaatatttt tactggtaat tcaattttta aatatgtttt tacaatgctt   1680

gaacacataa accttagaaa actggaaaat acgtgtccac agaaagagtt attagctact   1740

accttatgta aagatgcata gaaaatgaaa ttgttggaaa catgtgcaca aagtgtttta   1800

tattatatac attgtattta tgaagaataa ataaaatatt aagattgttt tcctgctagc   1860

caagagaaga aatccttggg aaatatctaa ggagtatatg gggctttata agcactgttt   1920

ctaaaagata ttctctggta cttttgcaaa aagtcgactg tgactgtgta gcattatgtt   1980

ctgtagaatt tttttcaagt agcataattt atttcattgg tgtgaaaaca gccaaaggtt   2040

ccaatatcct cacaaatcat ttatgccaaa catctgaggg caaaatttag ccggtgttat   2100

ttactagatt cttccctttg aactcacaga ctcaagagac agaccaagag ttcttatata   2160

ctcaccacag cggaccaatc caagtggcat ttttaggaaa ggttgcagca tttaatgcca   2220

tgtggtatgt ctgttcgtca agtgggtggc aagggaatat ccaagctggc attttggata   2280

tgatgggcct tttactttcc tgagtgacat gccacatgtc aagaaatact gctccccacc   2340

cccccactcc catcacattt acgtgaacaa ttttcattta gttatttccc gttccatatg   2400

gtgttaaaac agtcgtatta aataaagatt atttctagtt ttcagtggta atttaaatga   2460

gaggatatgt aataattgct tattagatac ttatccaaat gaaatataac agagtttaca   2520

gtacttaaaa tggctggtta tggtcttgga aatgtttgaa aattcattat cctgaaaaaa   2580

actttaccat tctgttttac ccttgaggta ttttttgggg aaaaatgttt ttgataacta   2640

ttaatctaaa tatagtataa ttataggcaa atttcactgc ctagttttat tgatatcctg   2700

agtctacagc tagtccattc gtatgactga ttgatttatg atagctccag agaaccataa   2760

atttcaaagg ctaaactctc tgattttagt aaatagtagg taaagtgaca caatatatgt   2820

ttacacaaca ctgttttcat gaaatgcaaa ctttgcaaaa ctcacattaa ctgggaagca   2880

gccaaccctc tgtagagaaa tcccagattg ggagtctggt ttgaatcttt gaagacagaa   2940

aggtgatatc cggcctgctg ttttaaaggg accacacttt tgaataccta ctggtgtttg   3000

gcagaaatct gagactggca ccagacacaa attttagaca tgggtatctt ccctccagta   3060

attcactgct cagagtaatt tagaagacaa aaacagaaaa aattgtaatg attttttaag   3120

tgttagaata tgtttgttaa catactctgc aaaataaatt tcaactaatg caatagactt   3180

aaaatatagc ctatggaata ctgtgattga agtttgaagg cttgctggtt cttattttgc   3240

atgcaagttt agacagggta aagaatgtat aaatttattt gagatgagat acagtattgt   3300

aaaaatataa cctcatctag aattgctttt aaaacaagca aaagcctatt ttagtacaaa   3360

tgtagggtgg gtagttgttt taaggtagca aaatacttca agattttcta tctttttaat   3420

ttttcatgaa gacagaagaa atactttcac cccaaccaat gactgtaaga tcttgagagt   3480

atgttcttac tcatttctgt aattgcagta gtgtagtcat ctgcatataa atttaataaa   3540

tgcatgttaa aatttaagtt gatgcctttt agtcctctca gagtctgtca cagtttcttt   3600

gtgtaaatga taaaaaagtt tgaatttaat caataaaact taaaaatcac aatatc       3656


<210>  4959
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  4959

Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr 
1               5                   10                  15      


Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu 
            20                  25                  30          


Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile 
        35                  40                  45              


Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala 
    50                  55                  60                  


Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp 
65                  70                  75                  80  


Leu Asp Gln Asp Glu Asp 
                85      


<210>  4960
<211>  371
<212>  DNA
<213>  Homosapiens

<400>  4960
taaatcacca tggatatatt cctgaaaaga gtgatacctt ctcaaggaga gcctcaggaa     60

ggtccttcag aagggattcc acaggaaggc actgttgtca caggagatga caactccagg    120

catgttactc tccctgaaga ctttccagtg ggacaagatg tggaggtgga agacaatgat    180

accgatgatc ctgacccttt ttttgctaag gtgtgtattt atgtcttggt ttttaacaaa    240

aaagtattaa aagtaggaaa aatgttaaaa actttaaaaa tagaaaaaag cttatagagt    300

atggatataa agaaaggaaa tattttgtac agctgtacaa tgtgatgtgt ttgtgtttgt    360

ttgtttgttt g                                                         371


<210>  4961
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  4961

Met Asp Ile Phe Leu Lys Arg Val Ile Pro Ser Gln Gly Glu Pro Gln 
1               5                   10                  15      


Glu Gly Pro Ser Glu Gly Ile Pro Gln Glu Gly Thr Val Val Thr Gly 
            20                  25                  30          


Asp Asp Asn Ser Arg His Val Thr Leu Pro Glu Asp Phe Pro Val Gly 
        35                  40                  45              


Gln Asp Val Glu Val Glu Asp Asn Asp Thr Asp Asp Pro Asp Pro Phe 
    50                  55                  60                  


Phe Ala Lys Val Cys Ile Tyr Val Leu Val Phe Asn Lys Lys Val Leu 
65                  70                  75                  80  


Lys Val Gly Lys Met Leu Lys Thr Leu Lys Ile Glu Lys Ser Leu 
                85                  90                  95  


<210>  4962
<211>  371
<212>  DNA
<213>  Homosapiens

<400>  4962
taaatcacca tggatatatt cctgaaaaga gtgatacctt ctcaaggaga gcctcaggaa     60

ggtccttcag aagggattcc acaggaaggc actgttgtca caggagatga caactccagg    120

catgttactc tccctgaaga ctttccagtg ggacaagatg tggaggtgga agacaatgat    180

accgatgatc ctgacccttt ttttgctaag gtgtgtattt atgtcttggt ttttaacaaa    240

aaagtattaa aagtaggaaa aatgttaaaa actttaaaaa tagaaaaaag cttatagagt    300

atggatataa agaaaggaaa tattttgtac agctgtacaa tgtgatgtgt ttgtgtttgt    360

ttgtttgttt g                                                         371


<210>  4963
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  4963

Met Asp Ile Phe Leu Lys Arg Val Ile Pro Ser Gln Gly Glu Pro Gln 
1               5                   10                  15      


Glu Gly Pro Ser Glu Gly Ile Pro Gln Glu Gly Thr Val Val Thr Gly 
            20                  25                  30          


Asp Asp Asn Ser Arg His Val Thr Leu Pro Glu Asp Phe Pro Val Gly 
        35                  40                  45              


Gln Asp Val Glu Val Glu Asp Asn Asp Thr Asp Asp Pro Asp Pro Phe 
    50                  55                  60                  


Phe Ala Lys Val Cys Ile Tyr Val Leu Val Phe Asn Lys Lys Val Leu 
65                  70                  75                  80  


Lys Val Gly Lys Met Leu Lys Thr Leu Lys Ile Glu Lys Ser Leu 
                85                  90                  95  


<210>  4964
<211>  1224
<212>  DNA
<213>  Homosapiens

<400>  4964
atgggcaact cattaagcat attttgttcc tggttccgcc acaggtcctg gccatgccat     60

tggcaacctg ctcgtcttgt ccatgaggcc ttcccagctg gccgggctaa ccccgcggct    120

cctgcacctg tgcctgcccg gggaatcgtg ggccgtttcc cactcctctt caaccctcag    180

cgacatcttg ggccttcttt tccagtcagt tgggacggcg cccctatgag gctgtgtctt    240

atccctcgga acatgggcac cccacagagg gtcctgtctc ctgtggtctg gagccccgcc    300

tcaaggaaga aacccatgct gtctgctcac aactccagga tgtttggaca cctcagcccc    360

gtgaggattc ctcatctcag aggcaagttt aaccttcaac ttccttcatt agatgagcag    420

gtgatcccag ccaggctccc gaagatggag gtgagggcag aagagcccag agaagcaacg    480

gaggtgacag accaggtaga gacccagggg caggaggaca ataaaagggg cccctgtagc    540

aatggggaag cagcttccac ctctaggccc ctggagactc agggaaactt cacttcctcc    600

tggtacaatc ccaggccctt ggagggaaat gtccacctca agagcttgac agaaaacaac    660

cagactgaca aggcccaggt gcctgcagtg agtttctact ccaacggcca tggagtcgcc    720

agttcacaca gccctgctgg aggcatcctt ccctttggga agcctgaccc acttccaaca    780

gtgctccctg ccccagttcc aggctgctcc ctgtggccag agaaggcggc cttgaaggtg    840

ctgggtaaag accacctgcc cagctctcca ggcttgctga tggtggggga ggacatgcag    900

cccaaggatc ctgcagctct tgggtcaagt aggtcttctc cacacagagc tgccggccac    960

agttcccaca aaagaaaact gtcggggcca ccgctgcagc tgcaaccgac ccctcccctg   1020

caactgaggt gggatagaga cgaggggccc ccaccggcta agcttccatg tctatctcct   1080

gaggcactgt tggtgggtca ggcttcccaa agagaaggac gcctccagca gggcaacatg   1140

tgtaagaaca tgagggtgtt aagtagaaca tcaaaattca ggagagtaag agagctgctt   1200

aggaggagaa agaagagatg gtag                                          1224


<210>  4965
<211>  407
<212>  PRT
<213>  Homosapiens

<400>  4965

Met Gly Asn Ser Leu Ser Ile Phe Cys Ser Trp Phe Arg His Arg Ser 
1               5                   10                  15      


Trp Pro Cys His Trp Gln Pro Ala Arg Leu Val His Glu Ala Phe Pro 
            20                  25                  30          


Ala Gly Arg Ala Asn Pro Ala Ala Pro Ala Pro Val Pro Ala Arg Gly 
        35                  40                  45              


Ile Val Gly Arg Phe Pro Leu Leu Phe Asn Pro Gln Arg His Leu Gly 
    50                  55                  60                  


Pro Ser Phe Pro Val Ser Trp Asp Gly Ala Pro Met Arg Leu Cys Leu 
65                  70                  75                  80  


Ile Pro Arg Asn Met Gly Thr Pro Gln Arg Val Leu Ser Pro Val Val 
                85                  90                  95      


Trp Ser Pro Ala Ser Arg Lys Lys Pro Met Leu Ser Ala His Asn Ser 
            100                 105                 110         


Arg Met Phe Gly His Leu Ser Pro Val Arg Ile Pro His Leu Arg Gly 
        115                 120                 125             


Lys Phe Asn Leu Gln Leu Pro Ser Leu Asp Glu Gln Val Ile Pro Ala 
    130                 135                 140                 


Arg Leu Pro Lys Met Glu Val Arg Ala Glu Glu Pro Arg Glu Ala Thr 
145                 150                 155                 160 


Glu Val Thr Asp Gln Val Glu Thr Gln Gly Gln Glu Asp Asn Lys Arg 
                165                 170                 175     


Gly Pro Cys Ser Asn Gly Glu Ala Ala Ser Thr Ser Arg Pro Leu Glu 
            180                 185                 190         


Thr Gln Gly Asn Phe Thr Ser Ser Trp Tyr Asn Pro Arg Pro Leu Glu 
        195                 200                 205             


Gly Asn Val His Leu Lys Ser Leu Thr Glu Asn Asn Gln Thr Asp Lys 
    210                 215                 220                 


Ala Gln Val Pro Ala Val Ser Phe Tyr Ser Asn Gly His Gly Val Ala 
225                 230                 235                 240 


Ser Ser His Ser Pro Ala Gly Gly Ile Leu Pro Phe Gly Lys Pro Asp 
                245                 250                 255     


Pro Leu Pro Thr Val Leu Pro Ala Pro Val Pro Gly Cys Ser Leu Trp 
            260                 265                 270         


Pro Glu Lys Ala Ala Leu Lys Val Leu Gly Lys Asp His Leu Pro Ser 
        275                 280                 285             


Ser Pro Gly Leu Leu Met Val Gly Glu Asp Met Gln Pro Lys Asp Pro 
    290                 295                 300                 


Ala Ala Leu Gly Ser Ser Arg Ser Ser Pro His Arg Ala Ala Gly His 
305                 310                 315                 320 


Ser Ser His Lys Arg Lys Leu Ser Gly Pro Pro Leu Gln Leu Gln Pro 
                325                 330                 335     


Thr Pro Pro Leu Gln Leu Arg Trp Asp Arg Asp Glu Gly Pro Pro Pro 
            340                 345                 350         


Ala Lys Leu Pro Cys Leu Ser Pro Glu Ala Leu Leu Val Gly Gln Ala 
        355                 360                 365             


Ser Gln Arg Glu Gly Arg Leu Gln Gln Gly Asn Met Cys Lys Asn Met 
    370                 375                 380                 


Arg Val Leu Ser Arg Thr Ser Lys Phe Arg Arg Val Arg Glu Leu Leu 
385                 390                 395                 400 


Arg Arg Arg Lys Lys Arg Trp 
                405         


<210>  4966
<211>  1133
<212>  DNA
<213>  Homosapiens

<400>  4966
atggccagac tcaacaatgg gcttcttaat gaaactggga aactgcagag ttcaagtggg     60

ggttgggtgc tgaaccgtgg ctcattccct cagggatcaa atatcagcag agtcatcaga    120

gaagaacata agaagaaaaa cccagaagtc cctgtcaatt ttgcagaatt ttccaagaaa    180

tgctctggga ggtggaagac aatgtccagt aaagagaaat ttaaatttgg tgaaatggca    240

aaggcggatg aagtgtgcta tgatcgggaa atgaaggatt atggaccagc taagggaggc    300

aagaagaagg atcctaatgc ccccaaaagg ccaccatctg gattcttcct gttctgttca    360

gaattccgcc ccaagatcaa atccacaaac cccggcatct ctattggaga cgtggcaaaa    420

aagttgggtg agatgtggaa taacttaaat gacagtgaaa agcagcctta cgtcactaag    480

gcggcaaagc tgaaggagaa gtatgagaag gatgttgttg actgtaagtt gaaaggaaag    540

ttttatggcg caaagcgtcc tgctaaagtt gcccggaaaa aggtggaaga ggaagatgaa    600

gaagacgagg aggaagaaga gaaggagaag gacgaggagg atgaacaaag aaactgttta    660

tctgtctcct tgtgaataca tagagtaggg gagcgccgta actgacacat ctcttattta    720

atgtctgttg ccctcattag gtttaattac aaaatttgat cacgatcgta ttgtagtctc    780

tcaaagtgct ctagaaattg tcagtggttt acatgaagtg gccatgggtg tctggagcac    840

cctgaaactg caccaaagtt gtacatattt ccaaacattt ttaaaatgaa aaggcactct    900

cgtgttctcc tcactctgtg cactttgccg ttggtgtgac aaggcattta aagatgtttc    960

tggcgttttc tttttatttg taaggtggtg ttaactatat ggttattggc tagaaatcct   1020

gagttatcaa ctgtatatct ctatagtttg taaaaagaac aaaacaaccg agacaaactc   1080

ttgatgctcc ttgctcggcg ttgaggctgt ggggaagatg ccttttggag ggg          1133


<210>  4967
<211>  224
<212>  PRT
<213>  Homosapiens

<400>  4967

Met Ala Arg Leu Asn Asn Gly Leu Leu Asn Glu Thr Gly Lys Leu Gln 
1               5                   10                  15      


Ser Ser Ser Gly Gly Trp Val Leu Asn Arg Gly Ser Phe Pro Gln Gly 
            20                  25                  30          


Ser Asn Ile Ser Arg Val Ile Arg Glu Glu His Lys Lys Lys Asn Pro 
        35                  40                  45              


Glu Val Pro Val Asn Phe Ala Glu Phe Ser Lys Lys Cys Ser Gly Arg 
    50                  55                  60                  


Trp Lys Thr Met Ser Ser Lys Glu Lys Phe Lys Phe Gly Glu Met Ala 
65                  70                  75                  80  


Lys Ala Asp Glu Val Cys Tyr Asp Arg Glu Met Lys Asp Tyr Gly Pro 
                85                  90                  95      


Ala Lys Gly Gly Lys Lys Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro 
            100                 105                 110         


Ser Gly Phe Phe Leu Phe Cys Ser Glu Phe Arg Pro Lys Ile Lys Ser 
        115                 120                 125             


Thr Asn Pro Gly Ile Ser Ile Gly Asp Val Ala Lys Lys Leu Gly Glu 
    130                 135                 140                 


Met Trp Asn Asn Leu Asn Asp Ser Glu Lys Gln Pro Tyr Val Thr Lys 
145                 150                 155                 160 


Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Val Val Asp Cys Lys 
                165                 170                 175     


Leu Lys Gly Lys Phe Tyr Gly Ala Lys Arg Pro Ala Lys Val Ala Arg 
            180                 185                 190         


Lys Lys Val Glu Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Lys 
        195                 200                 205             


Glu Lys Asp Glu Glu Asp Glu Gln Arg Asn Cys Leu Ser Val Ser Leu 
    210                 215                 220                 


<210>  4968
<211>  1133
<212>  DNA
<213>  Homosapiens

<400>  4968
atggccagac tcaacaatgg gcttcttaat gaaactggga aactgcagag ttcaagtggg     60

ggttgggtgc tgaaccgtgg ctcattccct cagggatcaa atatcagcag agtcatcaga    120

gaagaacata agaagaaaaa cccagaagtc cctgtcaatt ttgcagaatt ttccaagaaa    180

tgctctggga ggtggaagac aatgtccagt aaagagaaat ttaaatttgg tgaaatggca    240

aaggcggatg aagtgtgcta tgatcgggaa atgaaggatt atggaccagc taagggaggc    300

aagaagaagg atcctaatgc ccccaaaagg ccaccatctg gattcttcct gttctgttca    360

gaattccgcc ccaagatcaa atccacaaac cccggcatct ctattggaga cgtggcaaaa    420

aagttgggtg agatgtggaa taacttaaat gacagtgaaa agcagcctta cgtcactaag    480

gcggcaaagc tgaaggagaa gtatgagaag gatgttgttg actgtaagtt gaaaggaaag    540

ttttatggcg caaagcgtcc tgctaaagtt gcccggaaaa aggtggaaga ggaagatgaa    600

gaagacgagg aggaagaaga gaaggagaag gatgaggagg atgaacaaag aaactgttta    660

tctgtctcct tgtgaataca tagagtaggg gagcgccgta actgacacat ctcttattta    720

atgtctgttg ccctcattag gtttaattac aaaatttgat cacgatcgta ttgtagtctc    780

tcaaagtgct ctagaaattg tcagtggttt acatgaagtg gccatgggtg tctggagcac    840

cctgaaactg caccaaagtt gtacatattt ccaaacattt ttaaaatgaa aaggcactct    900

cgtgttctcc tcactctgtg cactttgccg ttggtgtgac aaggcattta aagatgtttc    960

tggcgttttc tttttatttg taaggtggtg ttaactatat ggttattggc tagaaatcct   1020

gagttatcaa ctgtatatct ctatagtttg taaaaagaac aaaacaaccg agacaaactc   1080

ttgatgctcc ttgctcggcg ttgaggctgt ggggaagatg ccttttggag ggg          1133


<210>  4969
<211>  224
<212>  PRT
<213>  Homosapiens

<400>  4969

Met Ala Arg Leu Asn Asn Gly Leu Leu Asn Glu Thr Gly Lys Leu Gln 
1               5                   10                  15      


Ser Ser Ser Gly Gly Trp Val Leu Asn Arg Gly Ser Phe Pro Gln Gly 
            20                  25                  30          


Ser Asn Ile Ser Arg Val Ile Arg Glu Glu His Lys Lys Lys Asn Pro 
        35                  40                  45              


Glu Val Pro Val Asn Phe Ala Glu Phe Ser Lys Lys Cys Ser Gly Arg 
    50                  55                  60                  


Trp Lys Thr Met Ser Ser Lys Glu Lys Phe Lys Phe Gly Glu Met Ala 
65                  70                  75                  80  


Lys Ala Asp Glu Val Cys Tyr Asp Arg Glu Met Lys Asp Tyr Gly Pro 
                85                  90                  95      


Ala Lys Gly Gly Lys Lys Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro 
            100                 105                 110         


Ser Gly Phe Phe Leu Phe Cys Ser Glu Phe Arg Pro Lys Ile Lys Ser 
        115                 120                 125             


Thr Asn Pro Gly Ile Ser Ile Gly Asp Val Ala Lys Lys Leu Gly Glu 
    130                 135                 140                 


Met Trp Asn Asn Leu Asn Asp Ser Glu Lys Gln Pro Tyr Val Thr Lys 
145                 150                 155                 160 


Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Val Val Asp Cys Lys 
                165                 170                 175     


Leu Lys Gly Lys Phe Tyr Gly Ala Lys Arg Pro Ala Lys Val Ala Arg 
            180                 185                 190         


Lys Lys Val Glu Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Lys 
        195                 200                 205             


Glu Lys Asp Glu Glu Asp Glu Gln Arg Asn Cys Leu Ser Val Ser Leu 
    210                 215                 220                 


<210>  4970
<211>  2960
<212>  DNA
<213>  Homosapiens

<400>  4970
cactctaggt ggcaggagca gcttcctgag ggagccaggg gcccagggcg tcctgtgttt     60

gtccacaccc tcctcatgct ccacgctgag aagccaccac ggccaccggg cctctgtcat    120

tcactctcac cccgccacac gggccctgcc cccaggaccc cagactcact ttgccgccat    180

ctcgtagaaa atcatccggt caaagttgct cgtgtgctgc cattcccgca tggcccgcca    240

cagtccctcc tccagcgtca tggtgggctt ccgccgggcc agggatcgga gaactgggct    300

gtaaaccagt gcagtcagtc ccagtctgta agcccaccct ccatcccggg cccacctggt    360

cccaacacct ggctcctgtc ctccccacac ctgtcctgcc atctgtccct gtcctgttct    420

cccccatgtg ggctcctcag cctccaggac acacccccaa gatccaacat caacagaagc    480

cactgagtgg cctctccgac tgcccctcaa gtcctcggtg ttatgatgtt gacaagtgaa    540

ctcagtgcta tgggtggaac atgtgtgtcc ccaacattcc tgtgttgaag ccctcagtgc    600

cagtgtgtca gtatttggag gcaatcaggg ttagagcagg tcatgagcgt gggtcccagt    660

catggaatcc gagctctgat aagggcagga ggagacacca gggctcttgc tctcagccac    720

aagagcacac agccagaggc agctctctcc agccaggaag agggccctga ccagacaccc    780

aatccgctgt caccttgatc tgggacttct ggcctctgga actgggagac atgaatgtgt    840

cttgataaag cacccagtct atgggattcg ttacggcaga gcctgagctg actgagacac    900

catgcacaca gaatgacctg ggagcgaggg ttaaagtgca ggttcctggg ccacaggact    960

gagcatttaa ccagcttcct ggggactctg gagcaaggca gcccctgggg acacagcctc   1020

agggtcctgg agcttgagga gcaggagcac atgtccagaa ccaaagcaga gcggtgtcca   1080

agccactgca agcagccagg cacagcttcc cacattccca caggagccaa ggcaaaggcc   1140

tgtgagcccg gggcggctac actccaagaa tcagggtccc cagtgcaccg ggactccgct   1200

ccaagggggg atgcaaccag ttccagggtg tgggggcagc gagactgttg gggaggaaga   1260

cgggaccgcc ttcacctaca ccccaggcag gggactcccc taggggaacg gccagtgtgt   1320

tgcacggtgg atatgctcaa gctcctgttt gctcatcagc gggaaacaaa gggtcacaga   1380

ggtgccgtgg ggtggagaga ggcagggact gggaatgaaa ccacaaactc tcccagatgc   1440

tgatgttgct gcctcacagt caccacagtc cacggctctg ggctgctggg ctcgtggtgc   1500

actcagagct atcactggag cccgtggctt tggggagcac tctcctagat ggcctagtcc   1560

tgataatggt agtaatgggg acagtaatcc taattgctgt catgtaatgt gtcatagtat   1620

gtgccaggca ctgtgctacg tatgtcatat gtgagttcaa gtcatctctt tgccatcctc   1680

tgaatgaagc accattgtcc ttttttctag gggggattga cggtgaagat gctaatacct   1740

gcccagcatc gaccctagtg cgggtcccaa gaccatcccc ctgtgcaggc tccaccaccg   1800

ctgtgctaac tggaccgcgg cagaagagtg ggtgtgtgcc aggtttctgc tgggccctgc   1860

agctcctccc cccagcccca tgtgatgtgc ccctggccat tgacactcag ttcgagggaa   1920

ggcactgggg tgtacactca aagacctaaa cccagggtgg gtgcggtggc tcacgtctgc   1980

aatcccagca ctttgggagg ctgaggcggg tggatcacaa ggccaggagt tcaagaccag   2040

cctgcttaac atagtgaaac cccgtctcta ctaaaaaata caaaaaaatt agccgggcat   2100

ggtggcgggc acctgtaatc ccaggtactt gggaggctga ggcaggagaa ttgcttgaac   2160

ccaggaggca gaggttgcgg tgagccaaga tcgcaccatt gcactccagc ctgggtgaca   2220

gtgcgagact ccatctcaaa caaacaaaca aaaaagacct aaacccaaac cgtggctcac   2280

gtcacaccaa gaaccctctc tgacctgggt cttctgtaaa catggttgtg aaaattattg   2340

aaagtaaaag ccgggcacgg tgggtcatgc ctgcaatcgc agcactttgg gaggccgagg   2400

cgggagaatc accagggcag gagattgaga gcatcctggc taacatggtg aaaccccgtc   2460

tctactaaaa atacaaaaaa attagccggg catggtggcg ggcacctgta gtcccagcta   2520

ctcgggagcc tgaggcagga gaatgacgtg aacctgggag gtagagcttg cagtgagccg   2580

agatcacgcc actgctctcc accctgggcg acagagtgag actccatctc aaaaaaaaaa   2640

aaaaaaagaa aagaaaagaa aagaaagtaa gtattggggc ggggcatgat ggctcatgcc   2700

tgtaatctca gcactttgag aggctgaggc gggcagatca actgaggtcg ggagttcaag   2760

accagcctga ccaacatgga gaaaccccat ctctacgaat acaaaattag ccaggcatgg   2820

tggcacatgc ctgtaatccc aactactcag gaagctgagg cagcagaatc acttgaaccc   2880

aggaggcgga ggttgtgatg agctgagatc gcgccattgc actccagcct gggcaacaag   2940

agtgaaagtc catctcaaaa                                               2960


<210>  4971
<211>  176
<212>  PRT
<213>  Homosapiens

<400>  4971

Met Thr Trp Glu Arg Gly Leu Lys Cys Arg Phe Leu Gly His Arg Thr 
1               5                   10                  15      


Glu His Leu Thr Ser Phe Leu Gly Thr Leu Glu Gln Gly Ser Pro Trp 
            20                  25                  30          


Gly His Ser Leu Arg Val Leu Glu Leu Glu Glu Gln Glu His Met Ser 
        35                  40                  45              


Arg Thr Lys Ala Glu Arg Cys Pro Ser His Cys Lys Gln Pro Gly Thr 
    50                  55                  60                  


Ala Ser His Ile Pro Thr Gly Ala Lys Ala Lys Ala Cys Glu Pro Gly 
65                  70                  75                  80  


Ala Ala Thr Leu Gln Glu Ser Gly Ser Pro Val His Arg Asp Ser Ala 
                85                  90                  95      


Pro Arg Gly Asp Ala Thr Ser Ser Arg Val Trp Gly Gln Arg Asp Cys 
            100                 105                 110         


Trp Gly Gly Arg Arg Asp Arg Leu His Leu His Pro Arg Gln Gly Thr 
        115                 120                 125             


Pro Leu Gly Glu Arg Pro Val Cys Cys Thr Val Asp Met Leu Lys Leu 
    130                 135                 140                 


Leu Phe Ala His Gln Arg Glu Thr Lys Gly His Arg Gly Ala Val Gly 
145                 150                 155                 160 


Trp Arg Glu Ala Gly Thr Gly Asn Glu Thr Thr Asn Ser Pro Arg Cys 
                165                 170                 175     


<210>  4972
<211>  802
<212>  DNA
<213>  Homosapiens

<400>  4972
gcggtttgct aagtggtcgg ttcctggagc tgcggtcttc tgctagcctg atccgcagct     60

tcagcctccg ccgcctcctc agccctcggc gccgccgcct gacccgcagg ccgccgcggg    120

ccgcagagcc catgagggcg cgggcaccgc cgccgcctcc gcggcgtcgc cgtcgtcccg    180

gagcgccccg agctggcgcg ggcatggccg cggcatgagc gtggagccgc cgccggagct    240

ggaggagaag gcggcgtcgg agcccgaggc gggagccatg ccggagaagc gcgcgggcgc    300

gcaggccgcg gggagcacct ggctacaagg ctttggccca ccaagtgtgt accatgctgc    360

tattgtcatc ttccttgaat tctttgcgtg gggccttttg acaactccaa tgttgactgt    420

tctacatgaa acattttctc aacacacatt cctcatgaat ggtctcattc aaggtgtaaa    480

gggcctgctc tcttttttga gtgccccact cattggtgcc ctgtctgatg tgtgggggag    540

gaagcccttt ctcctcggca ctgtattctt tacctgcttc ccaatcccac tgatgaggat    600

cagcccatgc cgggtgtggt ggcgtgcacc tgtagtccca gctacctgtg gcaggagaat    660

ggcttgaacc caggaagcgg aggttgcagt gagccaagat cacaccattg cactccagcc    720

taggcatggt gagactccat ctcaaaaaaa aaaaaaaatt aaattgtatt gattttctct    780

tttcaaaaaa aaaaaaaaaa aa                                             802


<210>  4973
<211>  171
<212>  DNA
<213>  Homosapiens

<400>  4973
atgggtcgta aagcagcagg gacaaattgc aacatggaca atgcatttgg cccaggatct     60

gctaatgaac atatagtgca gtggtggttc aagaagtttt acaaggaaga cgagagcctt    120

gaagatgagg agtgtagtgg ctgccattgg aagttgacaa caaccagttg a             171


<210>  4974
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  4974

Met Gly Arg Lys Ala Ala Gly Thr Asn Cys Asn Met Asp Asn Ala Phe 
1               5                   10                  15      


Gly Pro Gly Ser Ala Asn Glu His Ile Val Gln Trp Trp Phe Lys Lys 
            20                  25                  30          


Phe Tyr Lys Glu Asp Glu Ser Leu Glu Asp Glu Glu Cys Ser Gly Cys 
        35                  40                  45              


His Trp Lys Leu Thr Thr Thr Ser 
    50                  55      


<210>  4975
<211>  7522
<212>  DNA
<213>  Homosapiens

<400>  4975
cccgggcgag cccgccgtgc gcacagctct gcccgccgcc cctggagcgg atccccagcc     60

gtccctgggc gttctcccgg gttctagcaa agccccccgg ggtgcccatc agtttccttg    120

ggtgactaca gcgtgtgttt tttctttcct ctttcccctg cctgtgtgcc cttctccagg    180

atggcagagg cggaattgca caaggaaagg ctgcaagcca tagcagaaaa aagaaagagg    240

cagactgaaa tagaaggcaa gcgacaacag cttgacgagc agatacttct gctgcagcat    300

tccaagtcca aagtgcttcg ggagaaatgg ctgctgcagg gcatacccgc tggaactgcc    360

gaagaggagg aagccaggag gcggcagtct gaagaggatg agttcagagt caagcaactt    420

gaagataaca ttcagaggct ggagcaagaa atacaaacgc tagaaagtga agagtcccag    480

atatctgcca aagagcaaat catcctagag aaactgaagg aaacagaaaa atccttcaag    540

gactttcaga agggtttctc cagtacggat ggagatgcag taaattacat ttcctcccag    600

cttcccgacc tgccaatcct ctgttcacga acagcagaac catcacctgg gcaggacggg    660

accagcagag cggctggagt cgggtgggag aatgtgctgc taaaggaagg tgagtcagcc    720

tcgaacgcca cagaaacatc cggcccagac atgactatca agaagcctcc ccagctttct    780

gaggatgata tctggctaaa aagcgaggga gacaactata gtgccaccct cctggagcct    840

gctgccagct ctctttcccc agatcacaaa aacatggaaa ttgaggtgtc tgttgcagaa    900

tgtaaaagtg ttcctggaat cacctctacc ccacatccca tggaccatcc ctccgctttc    960

tattcacccc cgcataatgg cctccttact gatcaccacg aatccctgga taatgatgtt   1020

gccagagaga tccgctatct agatgaggtg ctagaggcca actgctgtga ttctgctgtg   1080

gatggaacgt acaatggaac atcctcccca gagcctggtg cagtggttct ggtgggcggc   1140

ctaagccccc ctgtccacga ggcgacccag ccagaaccca ctgaaagaac agctagccgg   1200

caggcacctc ctcacatcga gctcagtaat agcagccctg accccatggc agaggcagaa   1260

agaacaaatg gccattcccc cagccagcct agagatgcgc tgggggacag cctgcaggtg   1320

cctgtcagcc ccagctccac aaccagctca cggtgttctt cccgagatgg agagttcact   1380

ctcaccacac tgaaaaagga ggccaagttt gagctgcgtg ccttccatga ggacaagaag   1440

ccctccaagc tctttgagga tgacgagcat gagaaagaac aatactgcat tagaaaagtg   1500

aggccttcag aggagatgct ggagctggaa aaggagagga gagagctcat ccgcagccag   1560

gccgtcaaga agaatcctgg cattgcagca aaatggtgga atcccccgca ggaaaaaacc   1620

atcgaggagc agctggacga ggaacatctg gagtcgcaca aaaagtacaa ggagcgcaaa   1680

gagagaaggg cacagcagga acagttgctg ctgcagaagc agttacagca gcagcagcag   1740

cagcccccat cgcagctctg cacagcccct gcctcttctc atgaacgcgc aagcatgatt   1800

gacaaagcaa aggaggacat tgtcacagag cagatagatt tctctgctgc tcgcaaacaa   1860

tttcagctga tggagaattc caggcaagcg gtggccaagg gccagagtac acccaggctg   1920

ttctccatca agcctttcta caggcctctg gggtcagtca actcagacaa gccactgact   1980

aatccgagac caccttctgt cgggggacct ccagaagaca gtggtgcctc agccgccaag   2040

ggacagaaat cccccggtgc cctggagacc ccatcggcag caggaagcca gggcaacaca   2100

gcctctcagg ggaaggaagg gccctacagc gagccttcta aacgtgggcc cttatctaaa   2160

ctgtgggctg aggatggaga atttacgagc gcccgggctg tcctcactgt ggtcaaggat   2220

gatgaccatg ggattttgga tcagttctca agatctgtca atgtctcctt gacccaagag   2280

gagcttgact ctggtctgga cgaattgtcg gtgaggtctc aggataccac agtcctggag   2340

accctatcca atgatttcag catggacaac atcagtgaca gcggggcatc caatgagaca   2400

accaatgccc tccaggaaaa ttcactggct gatttttctc tgccccagac accacaaact   2460

gacaacccct cagagggccg aggagaaggc gtctccaagt catttagtga tcatggtttc   2520

tattcccctt cctccacgct gggggactct ccgttggttg atgacccctt ggagtatcag   2580

gctggcctcc tggtgcagaa tgccattcaa caagccatag ccgagcaggt ggataaagct   2640

gtgtccaaaa ccagcaggga tggagcagag caacagggac ctgaagcgac tgtagaggaa   2700

gctgaagctg cggctttcgg ctcagaaaag cctcagagca tgtttgagcc acctcaggtg   2760

tcttctcctg ttcaagagaa aagggatgta ttaccaaaga ttctgcctgc tgaagacagg   2820

gcgctcaggg aaagggggcc cccccagcca ctgccagctg tgcagcccag tggcccgatt   2880

aacatggagg agaccaggcc cgaaggaagc tatttcagca agtactcgga ggcagctgag   2940

ctgagaagca cagcctccct cctggccact caagaatctg acgtgatggt tgggcctttc   3000

aagctgaggt ccaggaaaca gcggactttg tccatgattg aggaagagat ccgagcagct   3060

caggaaaggg aagaggagct gaagaggcag agacaagtct tgcagagtac gcagagcccc   3120

aggacaaaga atgccccatc actgccctcc agaacatgct acaaaactgc tccagggaaa   3180

atagagaaag tcaaacctcc tccatccccc accactgaag gccccagctt gcagcctgac   3240

ttagcccctg aagaggctgc cggaacccag cggcccaaga atctgatgca gaccctcatg   3300

gaagactatg agacacacaa atctaaaagg cgcgagagaa tggatgatag tagttacact   3360

tctaagttac tgtcttgcaa ggtgacttcc gaggtcctcg aggccacacg ggttaatcga   3420

agaaagagcg cactggcttt gcgctgggaa gcagggatct atgccaacca ggaggaagaa   3480

gacaacgaat aaacttcctt caacccagga agcgtctttg gtgcttggga gaccaagaaa   3540

ccaagaaatt aacaactgaa agcattttaa tggactattt attaaagtgc aaacaaactc   3600

agcaatcctt atgtagacca gaagctgcaa tatacaatga tgaaaatgaa acgaaaagga   3660

agtcccccca tcagactctg gacacccagg aatcaaaaga gaaaggactt ttttggtgac   3720

tcaatcccag tgtctggttt ggggccaatc tacaatggat ccaaaaggac aaaacatgtt   3780

acaagcaaat caacatagtt gctgcaggcg gaactgagac cagcctctct gggcgatgaa   3840

ggacaatggt ggtagggcca cttagagagc agtagggccc aggctggtgc agcctacatg   3900

gcacaggata tttccctgca ccagtttccc acctgtcact tgcagcatca gagggtgttg   3960

cattaactcc attttctcca gcagccataa aatgaatggc gtttctctcc atatttgccc   4020

agaagaggca gttatgattc cacttctcct acatttaatt atttttaatt gagaacaact   4080

catgatcaca attcataaaa tccatatttt aagacaatag ttcttcatgt cacaaacaca   4140

atctattcta catgaggagg ctgagaaagg ggaagagaaa aacaaaccaa atggatgatg   4200

ttagctttag gatcgtgtct gcttataata ttcactgatc tgcagtttat gagaacacat   4260

tttcacagtt atgtttcttc ataggaaaac tatatttagt gggcaacaac tatttttatg   4320

atgggatggg ggagtatata cacgtataga atctgtacgc gttgaacaac ttggttcaag   4380

atggtggggg catttttaga gcggcaataa ttgaaaaaaa aggcgaactc tgccttggag   4440

aggtagatga taagaaataa aaaggtgttt ataactattt tgtattataa agtgggcctt   4500

agagatagga agaagaatga tggattcctt ttggatcaat cagaaaggaa acacgaaaga   4560

aaagtcagga aggtagagag agaaaaaggg agggaaggag aaagaatggg aataaaataa   4620

ggaggtaaga gatactattt ttgctgagca accagtgtgt ttcaggatga tacaaagaaa   4680

aatatagaat agaaataagt gcaggcttgg aatcagctac aaatcctaaa gatggggtgt   4740

gtgtggatgt gtgtgtgtgt gtgtgtacac cattgtgtgt ttgtaaaatg tgtatgttca   4800

tgagtaaggg tgtgtgtgtg tgtgtattaa aattccagag tgaccgtggc acttgggtgt   4860

acaggtaatt cctccagagc tgtttgctgg cttcaggagt ggagtgagaa tttctttttt   4920

atgaaaaggg atataaaggc accgagctga tgcagtattt gtaatattaa gttgacctaa   4980

caaggtattt gcatgagtca caattacaaa gttttgagcg gttttgtaat ttgacattta   5040

ggagagtctc ctatttattc tcatacttta cattcatgct tagtatacta tagaggatgc   5100

cagctttaat ctttctgtca tttaaagcaa tatgataagg gtattcaata attgggtgcc   5160

ctaaatttct ggatgagaaa attttcaatt ctggccatga gaaagaaaaa aaaataaaca   5220

gccttctttt tttttccttt gttttaaaac tgtggttttt taaaaaagca ataattaact   5280

cagacctcac taaaaatcat ttttgttttt atattgttat gtcataagct ctattatgtt   5340

attctaacaa gtagcaattt cacaaaattt gtatgtagat gttaacgcac atttcctttg   5400

cttcttttat tagactagtg ttgactttgg ggggggacat ttattcacaa atgagaagta   5460

ggcacaaagt aaaaaatgga accatctact aacaaggatc ctttaaaact gccaagggag   5520

ctctaacttg aagccacatc ctacagatgg cagcccaaat agcacatggg caattggcac   5580

catctttata tggttgagtc tcctgaatat tttgaatgaa ttctcaacaa aatgtgctag   5640

ccactgggga cgcaaaacaa gtaagatccc tgttgcaaga aattcatttt atagtgaggg   5700

aggttggcat ggagactaaa attctcagga aaatgagatc cgtgttagat tagaagtcct   5760

gatgtgaaat gggaggactc aggaaggagg atcgtcttta cctgaggatt tctagccaga   5820

ggtcccagat gcctgggctg agaacccagc gataaggggg cgttcccaaa gcagacacag   5880

ggataagaac agaggaggca gcagcattgc acagccccag gcacagtggc agttaggatg   5940

gctggagagt aggatagttc tatgggttgc ccaaaaaatg tgatgcgctt catgttttct   6000

ctgactcatg gatctggtag agaccataga catgatatag actaacttcc ccatttttca   6060

caagaggaaa ccatccttat gacttacctt aaagtttttt gttctgtttt gaaggaaacc   6120

atgtgcttca tgaaacctac agttgacaag agaatgtaca gctaagagaa aagcttaaga   6180

ggccacacta ttcgcggaat ggctttagag gcagatgaag tggtctttga ccacagttga   6240

ttgaaccaga gcacttattg cttaaagaat aacagagttc tagagctggg ggttcttggg   6300

ccatgctccg tgtgtggata aggaaagaaa tactgtttct gggactctcc cacagtcaca   6360

aagctgtttt cactgtggcc cctacatctc ttaacttttg ctattactcc tatgctgcct   6420

tccggattac tgctgtctat cttcttgctc cactcactga agatcctatt ataatcccat   6480

gaaaatgtaa attacagttt acttgggaga gccagatttt ctctgtgctc ttgagttttt   6540

tattcattca agaaaccttg ggccaccgct ttgtacatag caccgtgcta ggctctggga   6600

tcccaaatgg acccttttaa ctttctgaag atgggaccgt cccctggagg aaagtcattc   6660

ctgcctaatc catcgagaga aagaggctta cgaaaaactt tgcctctgat gctcagcccc   6720

acccccaaat agcacacaag cttgttaacc ccacctctta caaaatgttt agattctgta   6780

ggtgttaaaa gcctttctgg aagtattgca ttctgccgtg tttataggtg ttcactttcc   6840

tccagagctg attaactact gacatgactt ggctttctca tccagaaatt atggaaacag   6900

ggtctgtcag tggcaggagg ccgtgctgtg ttttacttgg atgacacaat gcagtttact   6960

tgcctcttca tacccatgca tgctgctcac cctagacaat gacatataag ccgtatatag   7020

atcaatgtcc acatatatat acacacacac atatatatat ataaagtgta acaaggaaca   7080

ctaaaacagt gttgattctt gtctctgaag acaaataatt aaaccttttt tttcccaact   7140

aaagaatgga tttaattaaa ctatgtattg aaaaaaaagt agcctaagtg ttagagatgg   7200

tgaatatatt ccattttagt taaagaacaa atttcctgaa ttttaagcat tcagtgagct   7260

gccaattttg attttgtgtt gctctttacc caaattattt tttctttgtt tttctttttt   7320

tgggggagga ggggaaaaaa gcagcaatac tgtgtttgga aattatactc tgtatctggt   7380

tttcctgtgt atgttaacca cttaaatgtt attatcctgc tttggtttta gagtgattgt   7440

gaggcattca atgcaagtat acagttattt tctcattaaa atccaatgtg tgttgagttt   7500

ttataaaaaa aaaaaaaaaa aa                                            7522


<210>  4976
<211>  1103
<212>  PRT
<213>  Homosapiens

<400>  4976

Met Ala Glu Ala Glu Leu His Lys Glu Arg Leu Gln Ala Ile Ala Glu 
1               5                   10                  15      


Lys Arg Lys Arg Gln Thr Glu Ile Glu Gly Lys Arg Gln Gln Leu Asp 
            20                  25                  30          


Glu Gln Ile Leu Leu Leu Gln His Ser Lys Ser Lys Val Leu Arg Glu 
        35                  40                  45              


Lys Trp Leu Leu Gln Gly Ile Pro Ala Gly Thr Ala Glu Glu Glu Glu 
    50                  55                  60                  


Ala Arg Arg Arg Gln Ser Glu Glu Asp Glu Phe Arg Val Lys Gln Leu 
65                  70                  75                  80  


Glu Asp Asn Ile Gln Arg Leu Glu Gln Glu Ile Gln Thr Leu Glu Ser 
                85                  90                  95      


Glu Glu Ser Gln Ile Ser Ala Lys Glu Gln Ile Ile Leu Glu Lys Leu 
            100                 105                 110         


Lys Glu Thr Glu Lys Ser Phe Lys Asp Phe Gln Lys Gly Phe Ser Ser 
        115                 120                 125             


Thr Asp Gly Asp Ala Val Asn Tyr Ile Ser Ser Gln Leu Pro Asp Leu 
    130                 135                 140                 


Pro Ile Leu Cys Ser Arg Thr Ala Glu Pro Ser Pro Gly Gln Asp Gly 
145                 150                 155                 160 


Thr Ser Arg Ala Ala Gly Val Gly Trp Glu Asn Val Leu Leu Lys Glu 
                165                 170                 175     


Gly Glu Ser Ala Ser Asn Ala Thr Glu Thr Ser Gly Pro Asp Met Thr 
            180                 185                 190         


Ile Lys Lys Pro Pro Gln Leu Ser Glu Asp Asp Ile Trp Leu Lys Ser 
        195                 200                 205             


Glu Gly Asp Asn Tyr Ser Ala Thr Leu Leu Glu Pro Ala Ala Ser Ser 
    210                 215                 220                 


Leu Ser Pro Asp His Lys Asn Met Glu Ile Glu Val Ser Val Ala Glu 
225                 230                 235                 240 


Cys Lys Ser Val Pro Gly Ile Thr Ser Thr Pro His Pro Met Asp His 
                245                 250                 255     


Pro Ser Ala Phe Tyr Ser Pro Pro His Asn Gly Leu Leu Thr Asp His 
            260                 265                 270         


His Glu Ser Leu Asp Asn Asp Val Ala Arg Glu Ile Arg Tyr Leu Asp 
        275                 280                 285             


Glu Val Leu Glu Ala Asn Cys Cys Asp Ser Ala Val Asp Gly Thr Tyr 
    290                 295                 300                 


Asn Gly Thr Ser Ser Pro Glu Pro Gly Ala Val Val Leu Val Gly Gly 
305                 310                 315                 320 


Leu Ser Pro Pro Val His Glu Ala Thr Gln Pro Glu Pro Thr Glu Arg 
                325                 330                 335     


Thr Ala Ser Arg Gln Ala Pro Pro His Ile Glu Leu Ser Asn Ser Ser 
            340                 345                 350         


Pro Asp Pro Met Ala Glu Ala Glu Arg Thr Asn Gly His Ser Pro Ser 
        355                 360                 365             


Gln Pro Arg Asp Ala Leu Gly Asp Ser Leu Gln Val Pro Val Ser Pro 
    370                 375                 380                 


Ser Ser Thr Thr Ser Ser Arg Cys Ser Ser Arg Asp Gly Glu Phe Thr 
385                 390                 395                 400 


Leu Thr Thr Leu Lys Lys Glu Ala Lys Phe Glu Leu Arg Ala Phe His 
                405                 410                 415     


Glu Asp Lys Lys Pro Ser Lys Leu Phe Glu Asp Asp Glu His Glu Lys 
            420                 425                 430         


Glu Gln Tyr Cys Ile Arg Lys Val Arg Pro Ser Glu Glu Met Leu Glu 
        435                 440                 445             


Leu Glu Lys Glu Arg Arg Glu Leu Ile Arg Ser Gln Ala Val Lys Lys 
    450                 455                 460                 


Asn Pro Gly Ile Ala Ala Lys Trp Trp Asn Pro Pro Gln Glu Lys Thr 
465                 470                 475                 480 


Ile Glu Glu Gln Leu Asp Glu Glu His Leu Glu Ser His Lys Lys Tyr 
                485                 490                 495     


Lys Glu Arg Lys Glu Arg Arg Ala Gln Gln Glu Gln Leu Leu Leu Gln 
            500                 505                 510         


Lys Gln Leu Gln Gln Gln Gln Gln Gln Pro Pro Ser Gln Leu Cys Thr 
        515                 520                 525             


Ala Pro Ala Ser Ser His Glu Arg Ala Ser Met Ile Asp Lys Ala Lys 
    530                 535                 540                 


Glu Asp Ile Val Thr Glu Gln Ile Asp Phe Ser Ala Ala Arg Lys Gln 
545                 550                 555                 560 


Phe Gln Leu Met Glu Asn Ser Arg Gln Ala Val Ala Lys Gly Gln Ser 
                565                 570                 575     


Thr Pro Arg Leu Phe Ser Ile Lys Pro Phe Tyr Arg Pro Leu Gly Ser 
            580                 585                 590         


Val Asn Ser Asp Lys Pro Leu Thr Asn Pro Arg Pro Pro Ser Val Gly 
        595                 600                 605             


Gly Pro Pro Glu Asp Ser Gly Ala Ser Ala Ala Lys Gly Gln Lys Ser 
    610                 615                 620                 


Pro Gly Ala Leu Glu Thr Pro Ser Ala Ala Gly Ser Gln Gly Asn Thr 
625                 630                 635                 640 


Ala Ser Gln Gly Lys Glu Gly Pro Tyr Ser Glu Pro Ser Lys Arg Gly 
                645                 650                 655     


Pro Leu Ser Lys Leu Trp Ala Glu Asp Gly Glu Phe Thr Ser Ala Arg 
            660                 665                 670         


Ala Val Leu Thr Val Val Lys Asp Asp Asp His Gly Ile Leu Asp Gln 
        675                 680                 685             


Phe Ser Arg Ser Val Asn Val Ser Leu Thr Gln Glu Glu Leu Asp Ser 
    690                 695                 700                 


Gly Leu Asp Glu Leu Ser Val Arg Ser Gln Asp Thr Thr Val Leu Glu 
705                 710                 715                 720 


Thr Leu Ser Asn Asp Phe Ser Met Asp Asn Ile Ser Asp Ser Gly Ala 
                725                 730                 735     


Ser Asn Glu Thr Thr Asn Ala Leu Gln Glu Asn Ser Leu Ala Asp Phe 
            740                 745                 750         


Ser Leu Pro Gln Thr Pro Gln Thr Asp Asn Pro Ser Glu Gly Arg Gly 
        755                 760                 765             


Glu Gly Val Ser Lys Ser Phe Ser Asp His Gly Phe Tyr Ser Pro Ser 
    770                 775                 780                 


Ser Thr Leu Gly Asp Ser Pro Leu Val Asp Asp Pro Leu Glu Tyr Gln 
785                 790                 795                 800 


Ala Gly Leu Leu Val Gln Asn Ala Ile Gln Gln Ala Ile Ala Glu Gln 
                805                 810                 815     


Val Asp Lys Ala Val Ser Lys Thr Ser Arg Asp Gly Ala Glu Gln Gln 
            820                 825                 830         


Gly Pro Glu Ala Thr Val Glu Glu Ala Glu Ala Ala Ala Phe Gly Ser 
        835                 840                 845             


Glu Lys Pro Gln Ser Met Phe Glu Pro Pro Gln Val Ser Ser Pro Val 
    850                 855                 860                 


Gln Glu Lys Arg Asp Val Leu Pro Lys Ile Leu Pro Ala Glu Asp Arg 
865                 870                 875                 880 


Ala Leu Arg Glu Arg Gly Pro Pro Gln Pro Leu Pro Ala Val Gln Pro 
                885                 890                 895     


Ser Gly Pro Ile Asn Met Glu Glu Thr Arg Pro Glu Gly Ser Tyr Phe 
            900                 905                 910         


Ser Lys Tyr Ser Glu Ala Ala Glu Leu Arg Ser Thr Ala Ser Leu Leu 
        915                 920                 925             


Ala Thr Gln Glu Ser Asp Val Met Val Gly Pro Phe Lys Leu Arg Ser 
    930                 935                 940                 


Arg Lys Gln Arg Thr Leu Ser Met Ile Glu Glu Glu Ile Arg Ala Ala 
945                 950                 955                 960 


Gln Glu Arg Glu Glu Glu Leu Lys Arg Gln Arg Gln Val Leu Gln Ser 
                965                 970                 975     


Thr Gln Ser Pro Arg Thr Lys Asn Ala Pro Ser Leu Pro Ser Arg Thr 
            980                 985                 990         


Cys Tyr Lys Thr Ala Pro Gly Lys  Ile Glu Lys Val Lys  Pro Pro Pro 
        995                 1000                 1005             


Ser Pro  Thr Thr Glu Gly Pro  Ser Leu Gln Pro Asp  Leu Ala Pro 
    1010                 1015                 1020             


Glu Glu  Ala Ala Gly Thr Gln  Arg Pro Lys Asn Leu  Met Gln Thr 
    1025                 1030                 1035             


Leu Met  Glu Asp Tyr Glu Thr  His Lys Ser Lys Arg  Arg Glu Arg 
    1040                 1045                 1050             


Met Asp  Asp Ser Ser Tyr Thr  Ser Lys Leu Leu Ser  Cys Lys Val 
    1055                 1060                 1065             


Thr Ser  Glu Val Leu Glu Ala  Thr Arg Val Asn Arg  Arg Lys Ser 
    1070                 1075                 1080             


Ala Leu  Ala Leu Arg Trp Glu  Ala Gly Ile Tyr Ala  Asn Gln Glu 
    1085                 1090                 1095             


Glu Glu  Asp Asn Glu 
    1100             


<210>  4977
<211>  5180
<212>  DNA
<213>  Homosapiens

<400>  4977
cccgggcgag cccgccgtgc gcacagctct gcccgccgcc cctggagcgg atccccagcc     60

gtccctgggc gttctcccgg gttctagcaa agccccccgg ggtgcccatc agtttccttg    120

ggtgactaca gcgtgtgttt tttctttcct ctttcccctg cctgtgtgcc cttctccagg    180

atggcagagg cggaattgca caaggaaagg ctgcaagcca tagcagaaaa aagaaagagg    240

cagactgaaa tagaaggcaa gcgacaacag cttgacgagc agatacttct gctgcagcat    300

tccaagtcca aagtgcttcg ggagaaatgg ctgctgcagg gcatacccgc tggaactgcc    360

gaagaggagg aagccaggag gcggcagtct gaagaggatg agttcagagt caagcaactt    420

gaagataaca ttcagaggct ggagcaagaa atacaaacgc tagaaagtga agagtcccag    480

atatctgcca aagagcaaat catcctagag aaactgaagg aaacagaaaa atccttcaag    540

gactttcaga agggtttctc cagtacggat ggagatgcag taaattacat ttcctcccag    600

cttcccgacc tgccaatcct ctgttcacga acagcagaac catcacctgg gcaggacggg    660

accagcagag cggctggagt cgggtgggag aatgtgctgc taaaggaagg tgagtcagcc    720

tcgaacgcca cagaaacatc cggcccagac atgactatca agaagcctcc ccagctttct    780

gaggatgata tctggctaaa aagcgaggga gacaactata gtgccaccct cctggagcct    840

gctgccagct ctctttcccc agatcacaaa aacatggaaa ttgaggtgtc tgttgcagaa    900

tgtaaaagtg ttcctggaat cacctctacc ccacatccca tggaccatcc ctccgctttc    960

tattcacccc cgcataatgg cctccttact gatcaccacg aatccctgga taatgatgtt   1020

gccagagaga tccgctatct agatgaggtg ctagaggcca actgctgtga ttctgctgtg   1080

gatggaacgt acaatggaac atcctcccca gagcctggtg cagtggttct ggtgggcggc   1140

ctaagccccc ctgtccacga ggcgacccag ccagaaccca ctgaaagaac agctagccgg   1200

caggcacctc ctcacatcga gctcagtaat agcagccctg accccatggc agaggcagaa   1260

agaacaaatg gccattcccc cagccagcct agagatgcgc tgggggacag cctgcaggtg   1320

cctgtcagcc ccagctccac aaccagctca cggtgttctt cccgagatgg agagttcact   1380

ctcaccacac tgaaaaagga ggccaagttt gagctgcgtg ccttccatga ggacaagaag   1440

ccctccaagc tctttgagga tgacgagcat gagaaagaac aatactgcat tagaaaagtg   1500

aggccttcag aggagatgct ggagctggaa aaggagagga gagagctcat ccgcagccag   1560

gccgtcaaga agaatcctgg cattgcagca aaatggtgga atcccccgca ggaaaaaacc   1620

atcgaggagc agctggacga ggaacatctg gagtcgcaca aaaagtacaa ggagcgcaaa   1680

gagagaaggg cacagcagga acagttgctg ctgcagaagc agttacagca gcagcagcag   1740

cagcccccat cgcagctctg cacagcccct gcctcttctc atgaacgcgc aagcatgatt   1800

gacaaagcaa aggaggacat tgtcacagag cagatagatt tctctgctgc tcgcaaacaa   1860

tttcagctga tggagaattc caggcaagcg gtggccaagg gccagagtac acccaggctg   1920

ttctccatca agcctttcta caggcctctg gggtcagtca actcagacaa gccactgact   1980

aatccgagac caccttctgt cgggggacct ccagaagaca gtggtgcctc agccgccaag   2040

ggacagaaat cccccggtgc cctggagacc ccatcggcag caggaagcca gggcaacaca   2100

gcctctcagg ggaaggaagg gccctacagc gagccttcta aacgtgggcc cttatctaaa   2160

ctgtgggctg aggatggaga atttacgagc gcccgggctg tcctcactgt ggtcaaggat   2220

gatgaccatg ggattttgga tcagttctca agatctgtca atgtctcctt gacccaagag   2280

gagcttgact ctggtctgga cgaattgtcg gtgaggtctc aggataccac agtcctggag   2340

accctatcca atgatttcag catggacaac atcagtgaca gcggggcatc caatgagaca   2400

accaatgccc tccaggaaaa ttcactggct gatttttctc tgccccagac accacaaact   2460

gacaacccct cagagggccg aggagaaggc gtctccaagt catttagtga tcatggtttc   2520

tattcccctt cctccacgct gggggactct ccgttggttg atgacccctt ggagtatcag   2580

gctggcctcc tggtgcagaa tgccattcaa caagccatag ccgagcaggt ggataaagct   2640

gtgtccaaaa ccagcaggga tggagcagag caacagggac ctgaagcgac tgtagaggaa   2700

gctgaagctg cggctttcgg ctcagaaaag cctcagagca tgtttgagcc acctcaggtg   2760

tcttctcctg ttcaagagaa aagggatgta ttaccaaaga ttctgcctgc tgaagacagg   2820

gcgctcaggg aaagggggcc cccccagcca ctgccagctg tgcagcccag tggcccgatt   2880

aacatggagg agaccaggcc cgaaggaagc tatttcagca agtactcgga ggcagctgag   2940

ctgagaagca cagcctccct cctggccact caagaatctg acgtgatggt tgggcctttc   3000

aagctgaggt ccaggaaaca gcggactttg tccatgattg aggaagagat ccgagcagct   3060

caggaaaggg aagaggagct gaagaggcag agacaagtct tgcagagtac gcagagcccc   3120

aggacaaaga atgccccatc actgccctcc agaacatgct acaaaactgc tccagggaaa   3180

atagagaaag tcaaacctcc tccatccccc accactgaag gccccagctt gcagcctgac   3240

ttagcccctg aagaggctgc cggaacccag cggcccaaga atctgatgca gaccctcatg   3300

gaagactatg agacacacaa atctaaaagg cgcgagagaa tggatgatag tagtgtcctc   3360

gaggccacac gggttaatcg aagaaagagc gcactggctt tgcgctggga agcagggatc   3420

tatgccaacc aggaggaaga agacaacgaa taaacttcct tcaacccagg aagcgtcttt   3480

ggtgcttggg agaccaagaa accaagaaat taacaactga aagcatttta atggactatt   3540

tattaaagtg caaacaaact cagcaatcct tatgtagacc agaagctgca atatacaatg   3600

atgaaaatga aacgaaaagg aagtcccccc atcagactct ggacacccag gaatcaaaag   3660

agaaaggact tttttggtga ctcaatccca gtgtctggtt tggggccaat ctacaatgga   3720

tccaaaagga caaaacatgt tacaagcaaa tcaacatagt tgctgcaggc ggaactgaga   3780

ccagcctctc tgggcgatga aggacaatgg tggtagggcc acttagagag cagtagggcc   3840

caggctggtg cagcctacat ggcacaggat atttccctgc accagtttcc cacctgtcac   3900

ttgcagcatc agagggtgtt gcattaactc cattttctcc agcagccata aaatgaatgg   3960

cgtttctctc catatttgcc cagaagaggc agttatgatt ccacttctcc tacatttaat   4020

tatttttaat tgagaacaac tcatgatcac aattcataaa atccatattt taagacaata   4080

gttcttcatg tcacaaacac aatctattct acatgaggag gctgagaaag gggaagagaa   4140

aaacaaacca aatggatgat gttagcttta ggatcgtgtc tgcttataat attcactgat   4200

ctgcagttta tgagaacaca ttttcacagt tatgtttctt cataggaaaa ctatatttag   4260

tgggcaacaa ctatttttat gatgggatgg gggagtatat acacgtatag aatctgtacg   4320

cgttgaacaa cttggttcaa gatggtgggg gcatttttag agcggcaata attgaaaaaa   4380

aaggcgaact ctgccttgga gaggtagatg ataagaaata aaaaggtgtt tataactatt   4440

ttgtattata aagtgggcct tagagatagg aagaagaatg atggattcct tttggatcaa   4500

tcagaaagga aacacgaaag aaaagtcagg aaggtagaga gagaaaaagg gagggaagga   4560

gaaagaatgg gaataaaata aggaggtaag agatactatt tttgctgagc aaccagtgtg   4620

tttcaggatg atacaaagaa aaatatagaa tagaaataag tgcaggcttg gaatcagcta   4680

caaatcctaa agatggggtg tgtgtggatg tgtgtgtgtg tgtgtgtaca ccattgtgtg   4740

tttgtaaaat gtgtatgttc atgagtaagg gtgtgtgtgt gtgtgtatta aaattccaga   4800

gtgaccgtgg cacttgggtg tacaggtaat tcctccagag ctgtttgctg gcttcaggag   4860

tggagtgaga atttcttttt tatgaaaagg gatataaagg caccgagctg atgcagtatt   4920

tgtaatatta agttgaccta acaaggtatt tgcatgagtc acaattacaa agttttgagc   4980

ggttttgtaa tttgacattt aggagagtct cctatttatt ctcatacttt acattcatgc   5040

ttagtatact atagaggatg ccagctttaa tctttctgtc atttaaagca atatgataag   5100

ggtattcaat aattgggtgc cctaaatttc tggatgagaa aattttcaat tctggccatg   5160

agaaaaaaaa aaaaaaaaaa                                               5180


<210>  4978
<211>  1090
<212>  PRT
<213>  Homosapiens

<400>  4978

Met Ala Glu Ala Glu Leu His Lys Glu Arg Leu Gln Ala Ile Ala Glu 
1               5                   10                  15      


Lys Arg Lys Arg Gln Thr Glu Ile Glu Gly Lys Arg Gln Gln Leu Asp 
            20                  25                  30          


Glu Gln Ile Leu Leu Leu Gln His Ser Lys Ser Lys Val Leu Arg Glu 
        35                  40                  45              


Lys Trp Leu Leu Gln Gly Ile Pro Ala Gly Thr Ala Glu Glu Glu Glu 
    50                  55                  60                  


Ala Arg Arg Arg Gln Ser Glu Glu Asp Glu Phe Arg Val Lys Gln Leu 
65                  70                  75                  80  


Glu Asp Asn Ile Gln Arg Leu Glu Gln Glu Ile Gln Thr Leu Glu Ser 
                85                  90                  95      


Glu Glu Ser Gln Ile Ser Ala Lys Glu Gln Ile Ile Leu Glu Lys Leu 
            100                 105                 110         


Lys Glu Thr Glu Lys Ser Phe Lys Asp Phe Gln Lys Gly Phe Ser Ser 
        115                 120                 125             


Thr Asp Gly Asp Ala Val Asn Tyr Ile Ser Ser Gln Leu Pro Asp Leu 
    130                 135                 140                 


Pro Ile Leu Cys Ser Arg Thr Ala Glu Pro Ser Pro Gly Gln Asp Gly 
145                 150                 155                 160 


Thr Ser Arg Ala Ala Gly Val Gly Trp Glu Asn Val Leu Leu Lys Glu 
                165                 170                 175     


Gly Glu Ser Ala Ser Asn Ala Thr Glu Thr Ser Gly Pro Asp Met Thr 
            180                 185                 190         


Ile Lys Lys Pro Pro Gln Leu Ser Glu Asp Asp Ile Trp Leu Lys Ser 
        195                 200                 205             


Glu Gly Asp Asn Tyr Ser Ala Thr Leu Leu Glu Pro Ala Ala Ser Ser 
    210                 215                 220                 


Leu Ser Pro Asp His Lys Asn Met Glu Ile Glu Val Ser Val Ala Glu 
225                 230                 235                 240 


Cys Lys Ser Val Pro Gly Ile Thr Ser Thr Pro His Pro Met Asp His 
                245                 250                 255     


Pro Ser Ala Phe Tyr Ser Pro Pro His Asn Gly Leu Leu Thr Asp His 
            260                 265                 270         


His Glu Ser Leu Asp Asn Asp Val Ala Arg Glu Ile Arg Tyr Leu Asp 
        275                 280                 285             


Glu Val Leu Glu Ala Asn Cys Cys Asp Ser Ala Val Asp Gly Thr Tyr 
    290                 295                 300                 


Asn Gly Thr Ser Ser Pro Glu Pro Gly Ala Val Val Leu Val Gly Gly 
305                 310                 315                 320 


Leu Ser Pro Pro Val His Glu Ala Thr Gln Pro Glu Pro Thr Glu Arg 
                325                 330                 335     


Thr Ala Ser Arg Gln Ala Pro Pro His Ile Glu Leu Ser Asn Ser Ser 
            340                 345                 350         


Pro Asp Pro Met Ala Glu Ala Glu Arg Thr Asn Gly His Ser Pro Ser 
        355                 360                 365             


Gln Pro Arg Asp Ala Leu Gly Asp Ser Leu Gln Val Pro Val Ser Pro 
    370                 375                 380                 


Ser Ser Thr Thr Ser Ser Arg Cys Ser Ser Arg Asp Gly Glu Phe Thr 
385                 390                 395                 400 


Leu Thr Thr Leu Lys Lys Glu Ala Lys Phe Glu Leu Arg Ala Phe His 
                405                 410                 415     


Glu Asp Lys Lys Pro Ser Lys Leu Phe Glu Asp Asp Glu His Glu Lys 
            420                 425                 430         


Glu Gln Tyr Cys Ile Arg Lys Val Arg Pro Ser Glu Glu Met Leu Glu 
        435                 440                 445             


Leu Glu Lys Glu Arg Arg Glu Leu Ile Arg Ser Gln Ala Val Lys Lys 
    450                 455                 460                 


Asn Pro Gly Ile Ala Ala Lys Trp Trp Asn Pro Pro Gln Glu Lys Thr 
465                 470                 475                 480 


Ile Glu Glu Gln Leu Asp Glu Glu His Leu Glu Ser His Lys Lys Tyr 
                485                 490                 495     


Lys Glu Arg Lys Glu Arg Arg Ala Gln Gln Glu Gln Leu Leu Leu Gln 
            500                 505                 510         


Lys Gln Leu Gln Gln Gln Gln Gln Gln Pro Pro Ser Gln Leu Cys Thr 
        515                 520                 525             


Ala Pro Ala Ser Ser His Glu Arg Ala Ser Met Ile Asp Lys Ala Lys 
    530                 535                 540                 


Glu Asp Ile Val Thr Glu Gln Ile Asp Phe Ser Ala Ala Arg Lys Gln 
545                 550                 555                 560 


Phe Gln Leu Met Glu Asn Ser Arg Gln Ala Val Ala Lys Gly Gln Ser 
                565                 570                 575     


Thr Pro Arg Leu Phe Ser Ile Lys Pro Phe Tyr Arg Pro Leu Gly Ser 
            580                 585                 590         


Val Asn Ser Asp Lys Pro Leu Thr Asn Pro Arg Pro Pro Ser Val Gly 
        595                 600                 605             


Gly Pro Pro Glu Asp Ser Gly Ala Ser Ala Ala Lys Gly Gln Lys Ser 
    610                 615                 620                 


Pro Gly Ala Leu Glu Thr Pro Ser Ala Ala Gly Ser Gln Gly Asn Thr 
625                 630                 635                 640 


Ala Ser Gln Gly Lys Glu Gly Pro Tyr Ser Glu Pro Ser Lys Arg Gly 
                645                 650                 655     


Pro Leu Ser Lys Leu Trp Ala Glu Asp Gly Glu Phe Thr Ser Ala Arg 
            660                 665                 670         


Ala Val Leu Thr Val Val Lys Asp Asp Asp His Gly Ile Leu Asp Gln 
        675                 680                 685             


Phe Ser Arg Ser Val Asn Val Ser Leu Thr Gln Glu Glu Leu Asp Ser 
    690                 695                 700                 


Gly Leu Asp Glu Leu Ser Val Arg Ser Gln Asp Thr Thr Val Leu Glu 
705                 710                 715                 720 


Thr Leu Ser Asn Asp Phe Ser Met Asp Asn Ile Ser Asp Ser Gly Ala 
                725                 730                 735     


Ser Asn Glu Thr Thr Asn Ala Leu Gln Glu Asn Ser Leu Ala Asp Phe 
            740                 745                 750         


Ser Leu Pro Gln Thr Pro Gln Thr Asp Asn Pro Ser Glu Gly Arg Gly 
        755                 760                 765             


Glu Gly Val Ser Lys Ser Phe Ser Asp His Gly Phe Tyr Ser Pro Ser 
    770                 775                 780                 


Ser Thr Leu Gly Asp Ser Pro Leu Val Asp Asp Pro Leu Glu Tyr Gln 
785                 790                 795                 800 


Ala Gly Leu Leu Val Gln Asn Ala Ile Gln Gln Ala Ile Ala Glu Gln 
                805                 810                 815     


Val Asp Lys Ala Val Ser Lys Thr Ser Arg Asp Gly Ala Glu Gln Gln 
            820                 825                 830         


Gly Pro Glu Ala Thr Val Glu Glu Ala Glu Ala Ala Ala Phe Gly Ser 
        835                 840                 845             


Glu Lys Pro Gln Ser Met Phe Glu Pro Pro Gln Val Ser Ser Pro Val 
    850                 855                 860                 


Gln Glu Lys Arg Asp Val Leu Pro Lys Ile Leu Pro Ala Glu Asp Arg 
865                 870                 875                 880 


Ala Leu Arg Glu Arg Gly Pro Pro Gln Pro Leu Pro Ala Val Gln Pro 
                885                 890                 895     


Ser Gly Pro Ile Asn Met Glu Glu Thr Arg Pro Glu Gly Ser Tyr Phe 
            900                 905                 910         


Ser Lys Tyr Ser Glu Ala Ala Glu Leu Arg Ser Thr Ala Ser Leu Leu 
        915                 920                 925             


Ala Thr Gln Glu Ser Asp Val Met Val Gly Pro Phe Lys Leu Arg Ser 
    930                 935                 940                 


Arg Lys Gln Arg Thr Leu Ser Met Ile Glu Glu Glu Ile Arg Ala Ala 
945                 950                 955                 960 


Gln Glu Arg Glu Glu Glu Leu Lys Arg Gln Arg Gln Val Leu Gln Ser 
                965                 970                 975     


Thr Gln Ser Pro Arg Thr Lys Asn Ala Pro Ser Leu Pro Ser Arg Thr 
            980                 985                 990         


Cys Tyr Lys Thr Ala Pro Gly Lys  Ile Glu Lys Val Lys  Pro Pro Pro 
        995                 1000                 1005             


Ser Pro  Thr Thr Glu Gly Pro  Ser Leu Gln Pro Asp  Leu Ala Pro 
    1010                 1015                 1020             


Glu Glu  Ala Ala Gly Thr Gln  Arg Pro Lys Asn Leu  Met Gln Thr 
    1025                 1030                 1035             


Leu Met  Glu Asp Tyr Glu Thr  His Lys Ser Lys Arg  Arg Glu Arg 
    1040                 1045                 1050             


Met Asp  Asp Ser Ser Val Leu  Glu Ala Thr Arg Val  Asn Arg Arg 
    1055                 1060                 1065             


Lys Ser  Ala Leu Ala Leu Arg  Trp Glu Ala Gly Ile  Tyr Ala Asn 
    1070                 1075                 1080             


Gln Glu  Glu Glu Asp Asn Glu  
    1085                 1090 


<210>  4979
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  4979
actcggctcc gggagaggcg agcagcgccg gtgagccccg cagcagcgca cccggccgcg     60

gagccccgcg atggagatgg cagaggcgga attgcacaag gaaaggctgc aagccatagc    120

agaaaaaaga aagaggcaga ctgaaataga aggcaagcga caacagcttg acgagcagat    180

acttctgctg cagcattcca agtccaaagt gcttcgggag aaatggctgc tgcagggcat    240

acccgctgga actgccgaag aggaggaagc caggaggcgg cagtctgaag aggatgagtt    300

cagagtcaag caacttgaag ataacattca gaggctggag caagaaatac aaacgctaga    360

aagtgaagag tcccagatat ctgccaaaga gcaaatcatc ctagagaaac tgaaggaaac    420

agaaaaatcc ttcaaggact ttcagaaggg tttctccagt acggatggag ctgtgtacgc    480

catggaaatt aatgtggaga aagacaaaca aacaggagag accaagattc tctctacatc    540

taccattggc ccagaggggg tccatcagaa aggagtcaaa gtctatgatg atggtaccaa    600

agtagtgtat gaggtgcgct caggaggcac cgtagtagaa aatggagtgc acaaattaag    660

cacaaaggat gtagaagagc ttattcagaa ggctggacaa tcaagcttag gaggagggca    720

cgtgtctgaa aggactgtga ttgcagatgg gagcctcagc catcccaagg aacacatgct    780

ctgcaaagaa gctaagttag aaatggtaca taagtctagg aaagaccatt cttccgggaa    840

cccagggcag caggcccaag cccccagcgc tgcagggccg gaggcaaact tggatcagcc    900

cgtcaccatg atttttatgg gctaccaaaa tatcgaggat gaagaggaga cgaaaaaggt    960

gctaggctat gatgaaacca tcaaggctga attggtcctc attgatgaag atgatgagaa   1020

gtcattgagg gagaagacag tgacggacgt gtccactatt gacgggaacg cggctgagct   1080

tgtgtccggg aggccggtct cagacaccac agagccctca tccccagaag ggaaggaaga   1140

gagcctagct acagagccag ccccaggtac ccaaaagaaa aagcgctgtc aatgctgtgt   1200

tgtcatgtga ccacttcttt cttctccttt cttctgggca gcctgtactc tccaccactc   1260

acgtagacct cactgtacca ctaactgcaa tactgtgaac tggaagcaaa cacctgcctt   1320

gccttgcagt tgaattgctt tgatctctct catttttttt ccttttcctc acctgagaga   1380

caacgtgcat gtgtgtgctt cattctctcc aagaacttgc ttttcctcta aacctttcct   1440

tgtgtcttca agagtgaatc acttccttcc tgctcgattg gaatggactc ttcgtatcag   1500

ccagtgatat ggtagcctta actcacttga ctggaattga acccattggc actgggggtt   1560

tcattttgta gtgtgttcct gtaacgtagt cacacactgc catgtctctg gtttctcact   1620

tgcctccttt gctgtggatc tttgttttta tatcttgtgt ggcaaaatgc tgttggctct   1680

agccggttgc tagtgtagcc aaaagtggac cttacttagt ctgtccgatc tagggtgatg   1740

ctttttgctg ccttacataa gcttccagat tacagtattg tgcattcatg gctttctttc   1800

tgttaaaact gaaatgaagt caatgtagaa gaacccagag cttgtcacag ctgaaatgta   1860

gggactgatt ccataacctg cccatcagcg gttgtctctc tttctatggt ttaaccgatg   1920

aaccctttat ataagaagca ccattttaaa atttctaagg acatgaaaca aacattgttt   1980

gaagcatcag tagcaattga tctccaaact taggcaaatt cacaagcctt gtttctattc   2040

tcttaaaaaa atgtaaattt ttatattgtt tcttttttct ggatattttc tggtcatgtt   2100

aatctatttt caatgaggag atcatcttga gaagtatctt tgcagtgacc atatttctaa   2160

aacagtctgt ccaacctaca atggttgcca tgatgctccc acttcatcat ggatggtgct   2220

gtaatgcatt aactgttcat ctcctcccca gttgattaca aagccttgca tccatactct   2280

tttctttctg gccccatgag aaagagaatg ttttaggtaa cttcaacttg taggtttatc   2340

tgcccttcaa aaaaaaaaac tttaaaaaac ttttaaaaat taagaaagac ctatcttctc   2400

aatgttaagc acttaatttc ataacaaata ttaagtggca catagctgag cttcttaggg   2460

cattgttttg tttttagctt ctggagattc cagaagagca aagaatattt tttatctaga   2520

acacaatgaa cagtttttga aataccttct cagcactccc ccaaagcaaa aagccacata   2580

tgtagtaaaa ccaaagggaa acaatttaat aaaataacaa tagtatagta atgaaataaa   2640

gatataacat gattactggt tttaataaga gttatcttaa ctttaagtta tttgcccatt   2700

tatagcattg ttatgaatta ttcataaaat tatgtcccac agtatatagt tttgaaaaaa   2760

catatgatat actacatcca gtctaacttc tgtggaaagt agatcagaaa aaataagata   2820

gtcttgagag aattttatta tagaagctgt ctaatttgac ctattttgct tgctcagtgc   2880

taaatctatt gctttttttt aatctcctgg cttgaaatta tatttacttc aataggaaag   2940

gtaaaaacat cagtttttac ttttcaaagt taattttctg aaataattgc attttaatga   3000

gcacaaaatg ggtcatttta tttttattat actcatcttg tttacaccta tacataaaca   3060

gaaaacgtta aagaagagaa aaataaagga gctaagttct gctgttgaag attatttcat   3120

ccaaggcttg gttttgaata actgagggaa atatctctaa atctcaagtt catcaaagca   3180

gctgcaatgg aataaaattg ctattttatc gagaaacctg gtttggatgc ttataaattc   3240

cactactctc agcttcattt tcctgagtac gtggtcactg aagcatcatt tagacattac   3300

ataaactggc atgcagataa acctatttac atagagggag aaaacagttt caatgtcttg   3360

gacaatctgt tattttaatg atttacttaa gaaagaaaca atctgaaagc ttaccatagc   3420

ttatcttttc tactcacttg gagattcaag ctattcaatg tgagttttaa aaagttaagc   3480

acagttagtg agtgaaatgg tagaatgtag aacctttaag cttgctggtt gataaacaga   3540

atcaatcttc caggacagat aattccctga agggacctat ccttgcataa gtgaactagt   3600

tactcataca gaaaatgatc tgcacatctt actacaacac tacacacaag aactaaaaga   3660

ttaatgatta tctgtattct cttcactaat tactattatg ggggaataat gattagcaaa   3720

ttatatgaat tcgagttctc tctatacttt tattagtaaa gcttatcatt taatggactg   3780

aagtaagatg tgttaccttt attcgagcta tttgtagcca cactaaatga aggtgtgttt   3840

gaatatggcg catatatttg catatgtccc atcattttct tgtcataatg gggaattcag   3900

gcttagccag tacttctatg ggatgagacc tataatccca cctatagcag caagtaacta   3960

cccttcatga tgatagtgta catggagctg tgattatgaa catgctgcct ttcctgctgc   4020

cattggcatt ctctctgtaa attttattat gtgtggtatc acactctcca aaaatgcagg   4080

gtatttggtt acataaccaa actaattaaa gaatcagtaa tgaaattgca aaaccatgat   4140

cttttttgag ctaatgatta gttgggcttt cctttaaaat aatataatca ggccgagtgc   4200

agcggctcac acctgtaatc tcggcacttt ggaagtccgc ggcgggtggt tcacctgagg   4260

tcgggagttc aagaccagcc tgaccaacat ggagaaaccc ccatctctac taaaaaaaaa   4320

atacaaaatt agccaggcgt gatggcgcat gcctgtaatc ccagctactc gggagactga   4380

ggcaggagaa tcgcttgaac ctgggaggca ggggttgcaa tgagccgaga tgtgcactcc   4440

agcctgggca acaaagagcg aaactccatc tcaaaaaaaa aaaaaaaaaa aaaaaaatca   4500

tataatcagt tcccttttaa atagaaagag gaggaaaaaa aaaaggaaaa gggggggtat   4560

ctcatttgta tacaaataga ttttcaatgg catttaataa aagattcttt aatggttaaa   4620

atgataaaga ttaattctac atatcttgaa aaatcttaat gacttctgta ttcttgactt   4680

cttaaaaata ttttctttct tttagtgtgc aataagacaa actaagggga attttttcag   4740

cttgtatctc ttttacccat attattttcc ttgcataagc aaaaaaataa taattgcctc   4800

taaaactgat ttgacagtgt tcagtgacat catttaatat tggtgatggg gtggaagaga   4860

aggtagggaa tgcccttatg gccaaaccta aaacacagtt tccttgagcc ttctgagcaa   4920

tcttagaatt attcagaagc tttcaggaaa ctcaaattct attaatttga tttggttcct   4980

ttccaaaatg ttaatagaca tgtatttgct taaaacgtct acctattcca tttaatttcc   5040

tgctgataaa tgtattttat ctacaagcaa gtagaatatt ttgttttggt taaagtcaag   5100

tttttataaa aggaggggaa gtataagaga gagtttccta gagatacaat atcatctctg   5160

gagcaaaatg ttgaggccaa gtgtaaaaac agactatttc tctttacttc ctgcagaatt   5220

tcatttcaag ggaccacagc acacccttga aaattaccat ttatttaatg ccagttgaac   5280

caatgggtag caaaagagga gggagggaac atggtcatag agacaaaatc taactactat   5340

accaggtctt cctttgtaag aaatattagc cctgccaata taaaacgcag atggacatag   5400

acagaataag catcgaggac tttttcttat ttacttgaaa tctagaagct cagtcatctc   5460

tgctcatccc tggacccact ggagagtttt actcactaac aggtcctttc ctggaagaaa   5520

taacctcatc tcctgccata ttagtttaca ataaaaatca ttccaaagtg agccatttca   5580

cattgcattt ttgccacatg cacatttgct attgaaacca cagattctca gcataagtaa   5640

gacataggtg tttcagaaac ttcataaata cacgatcttt caggtgctcc tcaatttctt   5700

aatcaaggta tattgaactc cagtgattag gatagaacct gaaaacatcc tttgttctat   5760

tggatagtac aacacagcaa gagcacacag ttatttgtat aataaaacaa cttaattaat   5820

gaggaagatg ggatgtttga ttcctgctac caccagttca cttcacaaag gccttcttct   5880

ggtattacca ggaaaacttt cctgcatttt ctagggaaaa agaaaagtcg tttattagga   5940

gcacaatgca gatatgtatc tgtgttttca tagcttcagc aaacttctta gtaaaattcc   6000

catttcaaca aaaaccaaaa tactgattgt ttgaatgtag aaaggtatag aataaagact   6060

acaaagggga attttaccag ggctccttag accagcttcc ccagcataat ttttatataa   6120

ctcaagtaag cctctgcttc ccctctcctt tccagtataa tataagaagg tcggaactgt   6180

cgcacaaaag aacttgattt caatatgaaa atataatatg taattttggg gactgcagac   6240

tttctgcatc aaagatctgg acagccttaa cttttataaa aataattttt caatgttctc   6300

ttttactaac caggaaaaca agatgttttc tgaaattaat gactttttct attttgggtc   6360

tgttttctaa gtttttacag gttgaggtat aaagggtcgt cttctcctca tattgcctct   6420

tcataatcac ctggggctat tttttgcaag tcactgcatt tttacaaaaa ataaaaataa   6480

aaagtacatc tcacaaatca taaaattctc cctagacttc agacagtcct tctggagtga   6540

aagaatagaa atacagaaag aaaagaatta cagggtggct ttctttttat tttcctatgg   6600

ttaatgtact gtatggtata tatgtttaca gaatgtatct gccttgtgat gttaacaaaa   6660

tgaatgacaa aaaatagtac tgatgtgcca tttgacagtt tgccttagca tcactgttta   6720

tgttcttctt ttctgtcctt tttggtaaaa aaaaacgcag gttgtattcc aaagctgtat   6780

taacacaaca ttctcttccc cactcctacc cagccttctt cagagctgtg aatttcatta   6840

caggagcatt gaggcagaac cttgcaggtg tggcccaaag gggctaaagt gggcataggt   6900

tgggatttac ttctgcccgt ctaccaacca aacacgtatc tgtgttctca tataagcctg   6960

caaaatttta caccctgcct ttcagggaga caggccacat ggagcgcatg acctcttgta   7020

gtcgtctcct cacagtcctt cccactgtga gagaaggaaa cttgcagacc cccaactgga   7080

tctgggagca tatttttaag cacagttggc attgcttgaa aaagcaagag agatggactc   7140

aaattctatg attgagccat gactgaggaa tgtgcccatt cgttatagtc gaagatgagt   7200

aggatgatat gggtgagaat aggagtggct gtagaaatgg aatattttac agttatgtat   7260

ttttttaagg aatagtattt ttataatgaa atctatatac attatggagc ttgagttgga   7320

aaacaccctt gactgagcta tttcttcatt ccattaaagg taactttctg gggagtccta   7380

tagcactagg ccaagccttg ggggcatgaa caaagggcct gtcacttggc cttgcactgc   7440

cattacatga gatccagtgt ttccaaatag gccttggttg gaagattgag ctttctatac   7500

ctgccattag gtagattaga tagatggctt gatagctctc tgggctatac ttttaataat   7560

atataataat ctttgggaag gagatagcta ttttaaatgc aagcaaagcc cagaaactat   7620

caaagtccaa atctttcaca tatttaagga gtaattgcca catttgaggt taagggacca   7680

cttactatgg tgcatttgag aaatatatat gaaacggtga gtcagagccc tctgaccatc   7740

ttcagtctac acataagcag ataaaccacc aatataaatc ttataggggc cagacgaggt   7800

ggcttatgcc tgtaatccca gcactttggg gggccaaggc aggaggatag tgtgagccca   7860

gaagttcaag accaggctag gcaacatgtt gagaccatgt tgtttagtct ctactaaaaa   7920

atataaaaat tagccagcat ggtggcacac acctgtagtc ccagctactt gggagactga   7980

ggcaggagga tcacttgagc ccaggaggtg gaggctgcag ggggctgaga tctcaccact   8040

ccattccagc ctgggcaaca gagcaagact ctgtctcaaa aaaaaaaaca aaaaaacaat   8100

tatcagttgg ccttctacat aacacagggc tacactgtat ttttagagtt aagtagatac   8160

aggaaaagat tgtctttatc cataaaggag at                                 8192


<210>  4980
<211>  379
<212>  PRT
<213>  Homosapiens

<400>  4980

Met Glu Met Ala Glu Ala Glu Leu His Lys Glu Arg Leu Gln Ala Ile 
1               5                   10                  15      


Ala Glu Lys Arg Lys Arg Gln Thr Glu Ile Glu Gly Lys Arg Gln Gln 
            20                  25                  30          


Leu Asp Glu Gln Ile Leu Leu Leu Gln His Ser Lys Ser Lys Val Leu 
        35                  40                  45              


Arg Glu Lys Trp Leu Leu Gln Gly Ile Pro Ala Gly Thr Ala Glu Glu 
    50                  55                  60                  


Glu Glu Ala Arg Arg Arg Gln Ser Glu Glu Asp Glu Phe Arg Val Lys 
65                  70                  75                  80  


Gln Leu Glu Asp Asn Ile Gln Arg Leu Glu Gln Glu Ile Gln Thr Leu 
                85                  90                  95      


Glu Ser Glu Glu Ser Gln Ile Ser Ala Lys Glu Gln Ile Ile Leu Glu 
            100                 105                 110         


Lys Leu Lys Glu Thr Glu Lys Ser Phe Lys Asp Phe Gln Lys Gly Phe 
        115                 120                 125             


Ser Ser Thr Asp Gly Ala Val Tyr Ala Met Glu Ile Asn Val Glu Lys 
    130                 135                 140                 


Asp Lys Gln Thr Gly Glu Thr Lys Ile Leu Ser Thr Ser Thr Ile Gly 
145                 150                 155                 160 


Pro Glu Gly Val His Gln Lys Gly Val Lys Val Tyr Asp Asp Gly Thr 
                165                 170                 175     


Lys Val Val Tyr Glu Val Arg Ser Gly Gly Thr Val Val Glu Asn Gly 
            180                 185                 190         


Val His Lys Leu Ser Thr Lys Asp Val Glu Glu Leu Ile Gln Lys Ala 
        195                 200                 205             


Gly Gln Ser Ser Leu Gly Gly Gly His Val Ser Glu Arg Thr Val Ile 
    210                 215                 220                 


Ala Asp Gly Ser Leu Ser His Pro Lys Glu His Met Leu Cys Lys Glu 
225                 230                 235                 240 


Ala Lys Leu Glu Met Val His Lys Ser Arg Lys Asp His Ser Ser Gly 
                245                 250                 255     


Asn Pro Gly Gln Gln Ala Gln Ala Pro Ser Ala Ala Gly Pro Glu Ala 
            260                 265                 270         


Asn Leu Asp Gln Pro Val Thr Met Ile Phe Met Gly Tyr Gln Asn Ile 
        275                 280                 285             


Glu Asp Glu Glu Glu Thr Lys Lys Val Leu Gly Tyr Asp Glu Thr Ile 
    290                 295                 300                 


Lys Ala Glu Leu Val Leu Ile Asp Glu Asp Asp Glu Lys Ser Leu Arg 
305                 310                 315                 320 


Glu Lys Thr Val Thr Asp Val Ser Thr Ile Asp Gly Asn Ala Ala Glu 
                325                 330                 335     


Leu Val Ser Gly Arg Pro Val Ser Asp Thr Thr Glu Pro Ser Ser Pro 
            340                 345                 350         


Glu Gly Lys Glu Glu Ser Leu Ala Thr Glu Pro Ala Pro Gly Thr Gln 
        355                 360                 365             


Lys Lys Lys Arg Cys Gln Cys Cys Val Val Met 
    370                 375                 


<210>  4981
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  4981
actcggctcc gggagaggcg agcagcgccg gtgagccccg cagcagcgca cccggccgcg     60

gagccccgcg atggagatgg cagaggcgga attgcacaag gaaaggctgc aagccatagc    120

agaaaaaaga aagaggcaga ctgaaataga aggcaagcga caacagcttg acgagcagat    180

acttctgctg cagcattcca agtccaaagt gcttcgggag aaatggctgc tgcagggcat    240

acccgctgga actgccgaag aggaggaagc caggaggcgg cagtctgaag aggatgagtt    300

cagagtcaag caacttgaag ataacattca gaggctggag caagaaatac aaacgctaga    360

aagtgaagag tcccagatat ctgccaaaga gcaaatcatc ctagagaaac tgaaggaaac    420

agaaaaatcc ttcaaggact ttcagaaggg tttctccagt acggatggag atgcagtaaa    480

ttacatttcc tcccagcttc ccgacctgcc aatcctctgt tcacgaacag cagaaccatc    540

acctgggcag gacgggacca gcagagcggc tgctgtgtac gccatggaaa ttaatgtgga    600

gaaagacaaa caaacaggag agaccaagat tctctctaca tctaccattg gcccagaggg    660

ggtccatcag aaaggagtca aagtctatga tgatggtacc aaagtagtgt atgaggtgcg    720

ctcaggaggc accgtagtag aaaatggagt gcacaaatta agcacaaagg atgtagaaga    780

gcttattcag aaggctggac aatcaagctt aggaggaggg cacgtgtctg aaaggactgt    840

gattgcagat gggagcctca gccatcccaa ggaacacatg ctctgcaaag aagctaagtt    900

agaaatggta cataagtcta ggaaagacca ttcttccggg aacccagggc agcaggccca    960

agcccccagc gctgcagggc cggaggcaaa cttggatcag cccgtcacca tgatttttat   1020

gggctaccaa aatatcgagg atgaagagga gacgaaaaag gtgctaggct atgatgaaac   1080

catcaaggct gaattggtcc tcattgatga agatgatgag aagtcattga gggagaagac   1140

agtgacggac gtgtccacta ttgacgggaa cgcggctgag cttgtgtccg ggaggccggt   1200

ctcagacacc acagagccct catccccaga agggaaggaa gagagcctag ctacagagcc   1260

agccccaggt acccaaaaga aaaagcgctg tcaatgctgt gttgtcatgt gaccacttct   1320

ttcttctcct ttcttctggg cagcctgtac tctccaccac tcacgtagac ctcactgtac   1380

cactaactgc aatactgtga actggaagca aacacctgcc ttgccttgca gttgaattgc   1440

tttgatctct ctcatttttt ttccttttcc tcacctgaga gacaacgtgc atgtgtgtgc   1500

ttcattctct ccaagaactt gcttttcctc taaacctttc cttgtgtctt caagagtgaa   1560

tcacttcctt cctgctcgat tggaatggac tcttcgtatc agccagtgat atggtagcct   1620

taactcactt gactggaatt gaacccattg gcactggggg tttcattttg tagtgtgttc   1680

ctgtaacgta gtcacacact gccatgtctc tggtttctca cttgcctcct ttgctgtgga   1740

tctttgtttt tatatcttgt gtggcaaaat gctgttggct ctagccggtt gctagtgtag   1800

ccaaaagtgg accttactta gtctgtccga tctagggtga tgctttttgc tgccttacat   1860

aagcttccag attacagtat tgtgcattca tggctttctt tctgttaaaa ctgaaatgaa   1920

gtcaatgtag aagaacccag agcttgtcac agctgaaatg tagggactga ttccataacc   1980

tgcccatcag cggttgtctc tctttctatg gtttaaccga tgaacccttt atataagaag   2040

caccatttta aaatttctaa ggacatgaaa caaacattgt ttgaagcatc agtagcaatt   2100

gatctccaaa cttaggcaaa ttcacaagcc ttgtttctat tctcttaaaa aaatgtaaat   2160

ttttatattg tttctttttt ctggatattt tctggtcatg ttaatctatt ttcaatgagg   2220

agatcatctt gagaagtatc tttgcagtga ccatatttct aaaacagtct gtccaaccta   2280

caatggttgc catgatgctc ccacttcatc atggatggtg ctgtaatgca ttaactgttc   2340

atctcctccc cagttgatta caaagccttg catccatact cttttctttc tggccccatg   2400

agaaagagaa tgttttaggt aacttcaact tgtaggttta tctgcccttc aaaaaaaaaa   2460

actttaaaaa acttttaaaa attaagaaag acctatcttc tcaatgttaa gcacttaatt   2520

tcataacaaa tattaagtgg cacatagctg agcttcttag ggcattgttt tgtttttagc   2580

ttctggagat tccagaagag caaagaatat tttttatcta gaacacaatg aacagttttt   2640

gaaatacctt ctcagcactc ccccaaagca aaaagccaca tatgtagtaa aaccaaaggg   2700

aaacaattta ataaaataac aatagtatag taatgaaata aagatataac atgattactg   2760

gttttaataa gagttatctt aactttaagt tatttgccca tttatagcat tgttatgaat   2820

tattcataaa attatgtccc acagtatata gttttgaaaa aacatatgat atactacatc   2880

cagtctaact tctgtggaaa gtagatcaga aaaaataaga tagtcttgag agaattttat   2940

tatagaagct gtctaatttg acctattttg cttgctcagt gctaaatcta ttgctttttt   3000

ttaatctcct ggcttgaaat tatatttact tcaataggaa aggtaaaaac atcagttttt   3060

acttttcaaa gttaattttc tgaaataatt gcattttaat gagcacaaaa tgggtcattt   3120

tatttttatt atactcatct tgtttacacc tatacataaa cagaaaacgt taaagaagag   3180

aaaaataaag gagctaagtt ctgctgttga agattatttc atccaaggct tggttttgaa   3240

taactgaggg aaatatctct aaatctcaag ttcatcaaag cagctgcaat ggaataaaat   3300

tgctatttta tcgagaaacc tggtttggat gcttataaat tccactactc tcagcttcat   3360

tttcctgagt acgtggtcac tgaagcatca tttagacatt acataaactg gcatgcagat   3420

aaacctattt acatagaggg agaaaacagt ttcaatgtct tggacaatct gttattttaa   3480

tgatttactt aagaaagaaa caatctgaaa gcttaccata gcttatcttt tctactcact   3540

tggagattca agctattcaa tgtgagtttt aaaaagttaa gcacagttag tgagtgaaat   3600

ggtagaatgt agaaccttta agcttgctgg ttgataaaca gaatcaatct tccaggacag   3660

ataattccct gaagggacct atccttgcat aagtgaacta gttactcata cagaaaatga   3720

tctgcacatc ttactacaac actacacaca agaactaaaa gattaatgat tatctgtatt   3780

ctcttcacta attactatta tgggggaata atgattagca aattatatga attcgagttc   3840

tctctatact tttattagta aagcttatca tttaatggac tgaagtaaga tgtgttacct   3900

ttattcgagc tatttgtagc cacactaaat gaaggtgtgt ttgaatatgg cgcatatatt   3960

tgcatatgtc ccatcatttt cttgtcataa tggggaattc aggcttagcc agtacttcta   4020

tgggatgaga cctataatcc cacctatagc agcaagtaac tacccttcat gatgatagtg   4080

tacatggagc tgtgattatg aacatgctgc ctttcctgct gccattggca ttctctctgt   4140

aaattttatt atgtgtggta tcacactctc caaaaatgca gggtatttgg ttacataacc   4200

aaactaatta aagaatcagt aatgaaattg caaaaccatg atcttttttg agctaatgat   4260

tagttgggct ttcctttaaa ataatataat caggccgagt gcagcggctc acacctgtaa   4320

tctcggcact ttggaagtcc gcggcgggtg gttcacctga ggtcgggagt tcaagaccag   4380

cctgaccaac atggagaaac ccccatctct actaaaaaaa aaatacaaaa ttagccaggc   4440

gtgatggcgc atgcctgtaa tcccagctac tcgggagact gaggcaggag aatcgcttga   4500

acctgggagg caggggttgc aatgagccga gatgtgcact ccagcctggg caacaaagag   4560

cgaaactcca tctcaaaaaa aaaaaaaaaa aaaaaaaaat catataatca gttccctttt   4620

aaatagaaag aggaggaaaa aaaaaaggaa aagggggggt atctcatttg tatacaaata   4680

gattttcaat ggcatttaat aaaagattct ttaatggtta aaatgataaa gattaattct   4740

acatatcttg aaaaatctta atgacttctg tattcttgac ttcttaaaaa tattttcttt   4800

cttttagtgt gcaataagac aaactaaggg gaattttttc agcttgtatc tcttttaccc   4860

atattatttt ccttgcataa gcaaaaaaat aataattgcc tctaaaactg atttgacagt   4920

gttcagtgac atcatttaat attggtgatg gggtggaaga gaaggtaggg aatgccctta   4980

tggccaaacc taaaacacag tttccttgag ccttctgagc aatcttagaa ttattcagaa   5040

gctttcagga aactcaaatt ctattaattt gatttggttc ctttccaaaa tgttaataga   5100

catgtatttg cttaaaacgt ctacctattc catttaattt cctgctgata aatgtatttt   5160

atctacaagc aagtagaata ttttgttttg gttaaagtca agtttttata aaaggagggg   5220

aagtataaga gagagtttcc tagagataca atatcatctc tggagcaaaa tgttgaggcc   5280

aagtgtaaaa acagactatt tctctttact tcctgcagaa tttcatttca agggaccaca   5340

gcacaccctt gaaaattacc atttatttaa tgccagttga accaatgggt agcaaaagag   5400

gagggaggga acatggtcat agagacaaaa tctaactact ataccaggtc ttcctttgta   5460

agaaatatta gccctgccaa tataaaacgc agatggacat agacagaata agcatcgagg   5520

actttttctt atttacttga aatctagaag ctcagtcatc tctgctcatc cctggaccca   5580

ctggagagtt ttactcacta acaggtcctt tcctggaaga aataacctca tctcctgcca   5640

tattagttta caataaaaat cattccaaag tgagccattt cacattgcat ttttgccaca   5700

tgcacatttg ctattgaaac cacagattct cagcataagt aagacatagg tgtttcagaa   5760

acttcataaa tacacgatct ttcaggtgct cctcaatttc ttaatcaagg tatattgaac   5820

tccagtgatt aggatagaac ctgaaaacat cctttgttct attggatagt acaacacagc   5880

aagagcacac agttatttgt ataataaaac aacttaatta atgaggaaga tgggatgttt   5940

gattcctgct accaccagtt cacttcacaa aggccttctt ctggtattac caggaaaact   6000

ttcctgcatt ttctagggaa aaagaaaagt cgtttattag gagcacaatg cagatatgta   6060

tctgtgtttt catagcttca gcaaacttct tagtaaaatt cccatttcaa caaaaaccaa   6120

aatactgatt gtttgaatgt agaaaggtat agaataaaga ctacaaaggg gaattttacc   6180

agggctcctt agaccagctt ccccagcata atttttatat aactcaagta agcctctgct   6240

tcccctctcc tttccagtat aatataagaa ggtcggaact gtcgcacaaa agaacttgat   6300

ttcaatatga aaatataata tgtaattttg gggactgcag actttctgca tcaaagatct   6360

ggacagcctt aacttttata aaaataattt ttcaatgttc tcttttacta accaggaaaa   6420

caagatgttt tctgaaatta atgacttttt ctattttggg tctgttttct aagtttttac   6480

aggttgaggt ataaagggtc gtcttctcct catattgcct cttcataatc acctggggct   6540

attttttgca agtcactgca tttttacaaa aaataaaaat aaaaagtaca tctcacaaat   6600

cataaaattc tccctagact tcagacagtc cttctggagt gaaagaatag aaatacagaa   6660

agaaaagaat tacagggtgg ctttcttttt attttcctat ggttaatgta ctgtatggta   6720

tatatgttta cagaatgtat ctgccttgtg atgttaacaa aatgaatgac aaaaaatagt   6780

actgatgtgc catttgacag tttgccttag catcactgtt tatgttcttc ttttctgtcc   6840

tttttggtaa aaaaaaacgc aggttgtatt ccaaagctgt attaacacaa cattctcttc   6900

cccactccta cccagccttc ttcagagctg tgaatttcat tacaggagca ttgaggcaga   6960

accttgcagg tgtggcccaa aggggctaaa gtgggcatag gttgggattt acttctgccc   7020

gtctaccaac caaacacgta tctgtgttct catataagcc tgcaaaattt tacaccctgc   7080

ctttcaggga gacaggccac atggagcgca tgacctcttg tagtcgtctc ctcacagtcc   7140

ttcccactgt gagagaagga aacttgcaga cccccaactg gatctgggag catattttta   7200

agcacagttg gcattgcttg aaaaagcaag agagatggac tcaaattcta tgattgagcc   7260

atgactgagg aatgtgccca ttcgttatag tcgaagatga gtaggatgat atgggtgaga   7320

ataggagtgg ctgtagaaat ggaatatttt acagttatgt atttttttaa ggaatagtat   7380

ttttataatg aaatctatat acattatgga gcttgagttg gaaaacaccc ttgactgagc   7440

tatttcttca ttccattaaa ggtaactttc tggggagtcc tatagcacta ggccaagcct   7500

tgggggcatg aacaaagggc ctgtcacttg gccttgcact gccattacat gagatccagt   7560

gtttccaaat aggccttggt tggaagattg agctttctat acctgccatt aggtagatta   7620

gatagatggc ttgatagctc tctgggctat acttttaata atatataata atctttggga   7680

aggagatagc tattttaaat gcaagcaaag cccagaaact atcaaagtcc aaatctttca   7740

catatttaag gagtaattgc cacatttgag gttaagggac cacttactat ggtgcatttg   7800

agaaatatat atgaaacggt gagtcagagc cctctgacca tcttcagtct acacataagc   7860

agataaacca ccaatataaa tcttataggg gccagacgag gtggcttatg cctgtaatcc   7920

cagcactttg gggggccaag gcaggaggat agtgtgagcc cagaagttca agaccaggct   7980

aggcaacatg ttgagaccat gttgtttagt ctctactaaa aaatataaaa attagccagc   8040

atggtggcac acacctgtag tcccagctac ttgggagact gaggcaggag gatcacttga   8100

gcccaggagg tggaggctgc agggggctga gatctcacca ctccattcca gcctgggcaa   8160

cagagcaaga ctctgtctca aaaaaaaaaa ca                                 8192


<210>  4982
<211>  413
<212>  PRT
<213>  Homosapiens

<400>  4982

Met Glu Met Ala Glu Ala Glu Leu His Lys Glu Arg Leu Gln Ala Ile 
1               5                   10                  15      


Ala Glu Lys Arg Lys Arg Gln Thr Glu Ile Glu Gly Lys Arg Gln Gln 
            20                  25                  30          


Leu Asp Glu Gln Ile Leu Leu Leu Gln His Ser Lys Ser Lys Val Leu 
        35                  40                  45              


Arg Glu Lys Trp Leu Leu Gln Gly Ile Pro Ala Gly Thr Ala Glu Glu 
    50                  55                  60                  


Glu Glu Ala Arg Arg Arg Gln Ser Glu Glu Asp Glu Phe Arg Val Lys 
65                  70                  75                  80  


Gln Leu Glu Asp Asn Ile Gln Arg Leu Glu Gln Glu Ile Gln Thr Leu 
                85                  90                  95      


Glu Ser Glu Glu Ser Gln Ile Ser Ala Lys Glu Gln Ile Ile Leu Glu 
            100                 105                 110         


Lys Leu Lys Glu Thr Glu Lys Ser Phe Lys Asp Phe Gln Lys Gly Phe 
        115                 120                 125             


Ser Ser Thr Asp Gly Asp Ala Val Asn Tyr Ile Ser Ser Gln Leu Pro 
    130                 135                 140                 


Asp Leu Pro Ile Leu Cys Ser Arg Thr Ala Glu Pro Ser Pro Gly Gln 
145                 150                 155                 160 


Asp Gly Thr Ser Arg Ala Ala Ala Val Tyr Ala Met Glu Ile Asn Val 
                165                 170                 175     


Glu Lys Asp Lys Gln Thr Gly Glu Thr Lys Ile Leu Ser Thr Ser Thr 
            180                 185                 190         


Ile Gly Pro Glu Gly Val His Gln Lys Gly Val Lys Val Tyr Asp Asp 
        195                 200                 205             


Gly Thr Lys Val Val Tyr Glu Val Arg Ser Gly Gly Thr Val Val Glu 
    210                 215                 220                 


Asn Gly Val His Lys Leu Ser Thr Lys Asp Val Glu Glu Leu Ile Gln 
225                 230                 235                 240 


Lys Ala Gly Gln Ser Ser Leu Gly Gly Gly His Val Ser Glu Arg Thr 
                245                 250                 255     


Val Ile Ala Asp Gly Ser Leu Ser His Pro Lys Glu His Met Leu Cys 
            260                 265                 270         


Lys Glu Ala Lys Leu Glu Met Val His Lys Ser Arg Lys Asp His Ser 
        275                 280                 285             


Ser Gly Asn Pro Gly Gln Gln Ala Gln Ala Pro Ser Ala Ala Gly Pro 
    290                 295                 300                 


Glu Ala Asn Leu Asp Gln Pro Val Thr Met Ile Phe Met Gly Tyr Gln 
305                 310                 315                 320 


Asn Ile Glu Asp Glu Glu Glu Thr Lys Lys Val Leu Gly Tyr Asp Glu 
                325                 330                 335     


Thr Ile Lys Ala Glu Leu Val Leu Ile Asp Glu Asp Asp Glu Lys Ser 
            340                 345                 350         


Leu Arg Glu Lys Thr Val Thr Asp Val Ser Thr Ile Asp Gly Asn Ala 
        355                 360                 365             


Ala Glu Leu Val Ser Gly Arg Pro Val Ser Asp Thr Thr Glu Pro Ser 
    370                 375                 380                 


Ser Pro Glu Gly Lys Glu Glu Ser Leu Ala Thr Glu Pro Ala Pro Gly 
385                 390                 395                 400 


Thr Gln Lys Lys Lys Arg Cys Gln Cys Cys Val Val Met 
                405                 410             


<210>  4983
<211>  6305
<212>  DNA
<213>  Homosapiens

<400>  4983
cccacatggc tttctagctc acagcagatc tagccttctc tgagcagtga agatgggatg     60

ttttgtggtc cttttccctg gtgtgcagag cccaagtgga gttcttcagc acaccctagt    120

ccatcccctc actaacacac ccacctgtcc agtcttacct gccttcatat caaaagcaca    180

cagttaaccc agagggcttc tgccctgccc tgcctgactt tctgggaaac ccccctctcc    240

acccacccta atcaggacac tgtctgaagg ttccccctca tcattttaaa aggaagagaa    300

attttctgcc acagaggttc tggtgaagtg gcctgctccc acatcacagg gtgatggcgg    360

tttgggctgg accaggatca gacagtgctg tcctgaggct ggccgtctga taaggggctc    420

cagaaagggc agtggtggag ccctgggagg ctttctgctc tcctgatcgc aggtttttgg    480

tgagaggacc tattggccac tagggtgtct gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt    540

gtgatgtgtg tttacttgga ttgacttctt tcagcatgaa gcccactgtt ttgctgaatg    600

tatctcactg tttcctgaaa ctcagtacat tcagctggct taagggtcct ggggcctcgc    660

tgcgtcatat ttgcacaagc ctagtgtctg tgcagactgt acactggagt tcagttgtaa    720

gacccttttg atcccttatt ctgttcctgt aatagaaaag ccatttcact caatggaata    780

gaaacccaga tccgatggag agatgttcta atctgccata cactggggca gtggccagtg    840

atttggactt tgtggcatag atggaaattt ccaggttgtc taggtggtag acagaggcct    900

cacttcttaa caaactcccc cactccaccc ctgccaatga ggatgttgct tagaggtatt    960

tctatcagtg ttgagtagaa gagatcattt cttgatgttg aacttcaggt aaggatgcca   1020

gcttctgcat atcagggtgg tgatgcttgg gctgagacag gtctagacag cactgtctga   1080

aagggggctc aaggaagtag ctgtgaaagg cccctgggat gttttctgct cccctttctg   1140

caaattccct ggagggagat cctgttagtc actacagggt gtgtgtgtgg gtgtgtgtgt   1200

gtgtgtgtgt gtgtgtgtgt gtgttcatca cttgttgctt gggggtggga agagacaaca   1260

aaagcctaca gaatctatag ttctcagttc atctcccatc ctagtccaat catggcctaa   1320

catccttagc tactgatcgc agaggagact ctgcgcattt gtgttcatgt ggccttggat   1380

gttggcagat tcagattggt gccccaggca tctgtgcctg taactgcagt ttcagcgggc   1440

tcaggaccag gctgaagggc ctccaagctt cctccagttt cctggtgcat gcatgtgcaa   1500

tatactcccc tggccttggt ctttcctaac gcttcttgcc agttgggtca gaactagctt   1560

attaaccagt tttttctgag ctttaatcga actggctcca accagttgga gacttgaaaa   1620

gggctacgtg atagttatag atttttaaag atatattatt attttagagt agttttgagt   1680

gcacagcaaa atggagtgca gagtccagag atctcatatg gcctcgattc ctgtacactc   1740

tcaggtcact ccaccaacaa cctcctacac cagagccact ttgaaacatt agaaaatata   1800

tttgagcatt cagaaatgta taaactaggc agctccagac tgcaagcagc tcagagttcc   1860

aacagagagg cttagggagg gtgggggaag aattttatat ggtgaatgtg gaagaaaaaa   1920

tacttgattg ggtaaagtgg agcagtggcc tcatttggaa cattacagtg gaaagtctct   1980

agttagatat tagttggtgg tttctgactg gttaagctta agtttccttt tattatttac   2040

actgagtcaa gttttggttt atttaaggag gaattgagtg cactgcagcc acctcagcct   2100

catggccacc tgtttatttg attattttta aaagagaaga gccttttaaa aatatctgtt   2160

gccctggctg gagtgcagtg acgtgatcat ggctcactgc agccacaacc ttccagctca   2220

ggtgatcctc ccacctcagt gctccccacc ctgagtagct gggactacaa gcatgtgcca   2280

gcacaccacc atgctaggct aatggtttgt atttttttga gagatgcagt ttccctaagt   2340

tgcttaggct tcttttgaac tcttagactc aaataatctg cctgcattgg cctccccaag   2400

tgctggaatt acaggccatc taaatctttt atctcagatt tgccttgtga caaatggagg   2460

ggtacttttt ctgacatgat gaggcagaga aaggtgaggt gggcgcatcc tgtgcatatg   2520

attttctcag gtgatgggaa tatggtcggc tcttgcctaa tgggatatat tttctctttg   2580

aatgatttgg caagatatca gatgagagaa gttgaataaa tgttagaaga acatagaaaa   2640

aataggttat acacgttggg tttctgaaga aatgatgtct ttggagaaac aaaactttta   2700

ttgatttctg gaaacattta gggccaattt tttatgtaaa taatttgaat ttatgatgat   2760

atctctgacc actttttgat atttttttct ggttcaggtg agtggtgtca ttgagcaaac   2820

acgaagtcgg gctcatccaa ggatgagatt ttgccagaga aaggacgagc agcaagtcag   2880

ggagcttaag gtaattatgg gaaagtgact atctacaatt gcttaggtag aaggagacag   2940

attggatttt tgtgtgtttg gtatttggga taagagggat gtgggtgtgt acttgacatg   3000

ggttgttctc tctctctctt tttttttttt ttttttttga gagggagtct cactctgtca   3060

cccaggctgg agttctgtgg cacagtcttg gctcactgca acctccgcct gccgggttca   3120

agggattctc ctgcctcagc ctcccaagta gctggggtta caggtgcctg ccaccacgcc   3180

ctgctaattt ttgtgatttt ttttttagta gagacgaggt ttcactatgt aggcaaagct   3240

ggtctcgaac tcctgacctc agatgatcca cccgcctcag cctcccaaag tgctgggatt   3300

acaggcgtga gccaccgcac ctggcctgtt tattctctta agagagaaaa tgaggggatt   3360

aatggactgt agttctggac aaggtggaaa actcttaaag tggaagtatt ggggcaagtg   3420

ctctgacagg ctaggatggt gcagtcagtc ccttcaccca gaaatcagta gaatgttaac   3480

agttcagact caaaccttgt gaaaaacagg tggtggaaag gaaatccctc acagcaactg   3540

gcaccataat caagacagaa tgtttgcaga ataaatggag ttacctgctt tcagccccag   3600

gttgtagcta ttgtctgccc tgatgatatg tgataataat ttgtgatcct attgtcttaa   3660

aatggggtca ctcatctcca gtagaattaa gtccacagtg aagttgtccc cccatcccca   3720

aagagataaa catatatgaa tgaactcaca tgataacaac tactgctgcc tgggatcatg   3780

agagacctga actgaactga taggaagtga aaggtggctg agataatgag aatagaccca   3840

tctgcagagg atcataaaac cagcaaagac aagatcttgt ctaagatgcc ttcacaaact   3900

ttgtccatga gaactctaag gacttctcca gacctgttgg ctgctgctgt gatctctgcc   3960

caagaggagc ctctgaccaa catccaaagg gcttctggac ccactggact cctctggagc   4020

gtcagcctcg agtttgacca gcaacagggg tcggtgtgtc cctctgaatc tgagatctat   4080

gaggcaggag ctggggacag gatggcagga gcgcccatgg ctgctgctgt gcagcctgct   4140

gaggtgaccg ttgaagttgg tgaggacctc cacatgcacc acattcgtga ccaggagatg   4200

cctgaagctt tggagtttag cctttctgcc aatccagagg caagcacaat attccagagg   4260

aactctcaaa cagatgcttt ggagtttaac ccttctgcca atccagaggc aagcacaata   4320

ttccagagga actctcaaac agatgttgta gaaataagaa gaagcaactg tacaaaccat   4380

gtatctactg agcgtttcag tcaacaatac agctcgtgtt cgacaatatt ccttgatgac   4440

agcacagcca gccagcatta tcttacaatg acaataatat ctgtgacctt ggagatacct   4500

catcatatca cacaaagaga tgcagataga tctttgagca tacctgatga acagttacac   4560

tcatttgcgg tttccaccgt gcacattacg aagaacagaa atggaggtgg gagtttaaat   4620

aactattcct cctccattcc atcgactccc agcaccagcc aggaggaccc tcagttcagt   4680

gttcctccca ctgccaacac acccaccccc gtttgcaagc ggtccatgcg ctggtccaac   4740

ctgtttacat ctgagaaagg gagtcaccca gacaaagaga ggaaagcccc ggagaatcat   4800

gctgacacca tcgggagcgg cagagccatc cccattaaac agggcatgct cttaaagcga   4860

agtgggaaat ggctgaagac atggaaaaag aaatacgtca ccctgtgttc caatggcgtg   4920

ctcacctatt attcaagctt aggtgattat atgaagaata ttcataaaaa agagattgac   4980

cttcggacat ctaccatcaa agtcccagga aagtggccat ccctagccac atcggcctgt   5040

gcacccatct ccagctctaa aagcaatggc ctatccaagg acatggacac cgggctgggt   5100

gactccatat gcttcagccc cagtatctcc agcaccacca gccccaagct caacccgccc   5160

ccctctcctc atgccaataa aaagaaacac ctaaagaaga aaagcaccaa caactttatg   5220

attgtgtctg ccactggcca aacatggcac tttgaagcca cgacgtatga ggagcgggat   5280

gcctgggtcc aagccatcca gagccagagc gaggccatgg ccctgcagtc gatccaaaac   5340

atgcgtggga acgcccactg tgtggactat gagacccaga atcctaagtg ggccagtttg   5400

aacttgggag tcctcatgtg tattgaatgc tcaggaatcc accgcagtct tggcacccgc   5460

ctttcccgtg tgcgatctct ggagctggat gactggccag ttgagctcag gaaggttatg   5520

tcatctattg gcaatgacct agccaacagc atctgggaag ggagcagcca ggggcagaca   5580

aaaccctcag taaagtccac gagggaagag aaggaacggt ggatccgttc caaatatgag   5640

gagaagctct ttctggcccc actaccctgc actgagctgt ccctgggcca gcacctgctg   5700

cgggccaccg ctgatgagga cctgcagaca gccatcctgc tgctggcaca tggctcccgt   5760

gaggaggtga acgagacctg tggggaggga gacggctgca cggcgctcca tctggcctgc   5820

cgcaagggga atgtggtcct ggcacagctc ctgatctggt acggggtgga cgtcatggcc   5880

cgagatgccc acgggaacac agcgctgacc tacgcccggc aggcctccag ccaggagtgc   5940

atcaacgtgc ttctgcagta cggctgcccc gacgagtgcg tgtagtatct gttttatttg   6000

actgcagtct ccttggtgca aaaacaaaat gggaaaaata aggataactc agaatttcaa   6060

aaggaaatca caaattcagc tagtaatagc attttcagta cttttcataa actaagtaaa   6120

tacacaaaat gttgattttt ctgaccataa gacatatttt atgtcctttt gccaaggtgg   6180

atgtgttagt ctcaggccct cctggccaca ttgcccaagt cacacaggct tctgtattat   6240

gtatttagat aaaatgtgtg aaaatatatt tgaaaaaaaa gttcataaat atgcattgat   6300

ttttg                                                               6305


<210>  4984
<211>  699
<212>  PRT
<213>  Homosapiens

<400>  4984

Met Pro Ser Gln Thr Leu Ser Met Arg Thr Leu Arg Thr Ser Pro Asp 
1               5                   10                  15      


Leu Leu Ala Ala Ala Val Ile Ser Ala Gln Glu Glu Pro Leu Thr Asn 
            20                  25                  30          


Ile Gln Arg Ala Ser Gly Pro Thr Gly Leu Leu Trp Ser Val Ser Leu 
        35                  40                  45              


Glu Phe Asp Gln Gln Gln Gly Ser Val Cys Pro Ser Glu Ser Glu Ile 
    50                  55                  60                  


Tyr Glu Ala Gly Ala Gly Asp Arg Met Ala Gly Ala Pro Met Ala Ala 
65                  70                  75                  80  


Ala Val Gln Pro Ala Glu Val Thr Val Glu Val Gly Glu Asp Leu His 
                85                  90                  95      


Met His His Ile Arg Asp Gln Glu Met Pro Glu Ala Leu Glu Phe Ser 
            100                 105                 110         


Leu Ser Ala Asn Pro Glu Ala Ser Thr Ile Phe Gln Arg Asn Ser Gln 
        115                 120                 125             


Thr Asp Ala Leu Glu Phe Asn Pro Ser Ala Asn Pro Glu Ala Ser Thr 
    130                 135                 140                 


Ile Phe Gln Arg Asn Ser Gln Thr Asp Val Val Glu Ile Arg Arg Ser 
145                 150                 155                 160 


Asn Cys Thr Asn His Val Ser Thr Glu Arg Phe Ser Gln Gln Tyr Ser 
                165                 170                 175     


Ser Cys Ser Thr Ile Phe Leu Asp Asp Ser Thr Ala Ser Gln His Tyr 
            180                 185                 190         


Leu Thr Met Thr Ile Ile Ser Val Thr Leu Glu Ile Pro His His Ile 
        195                 200                 205             


Thr Gln Arg Asp Ala Asp Arg Ser Leu Ser Ile Pro Asp Glu Gln Leu 
    210                 215                 220                 


His Ser Phe Ala Val Ser Thr Val His Ile Thr Lys Asn Arg Asn Gly 
225                 230                 235                 240 


Gly Gly Ser Leu Asn Asn Tyr Ser Ser Ser Ile Pro Ser Thr Pro Ser 
                245                 250                 255     


Thr Ser Gln Glu Asp Pro Gln Phe Ser Val Pro Pro Thr Ala Asn Thr 
            260                 265                 270         


Pro Thr Pro Val Cys Lys Arg Ser Met Arg Trp Ser Asn Leu Phe Thr 
        275                 280                 285             


Ser Glu Lys Gly Ser His Pro Asp Lys Glu Arg Lys Ala Pro Glu Asn 
    290                 295                 300                 


His Ala Asp Thr Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly 
305                 310                 315                 320 


Met Leu Leu Lys Arg Ser Gly Lys Trp Leu Lys Thr Trp Lys Lys Lys 
                325                 330                 335     


Tyr Val Thr Leu Cys Ser Asn Gly Val Leu Thr Tyr Tyr Ser Ser Leu 
            340                 345                 350         


Gly Asp Tyr Met Lys Asn Ile His Lys Lys Glu Ile Asp Leu Arg Thr 
        355                 360                 365             


Ser Thr Ile Lys Val Pro Gly Lys Trp Pro Ser Leu Ala Thr Ser Ala 
    370                 375                 380                 


Cys Ala Pro Ile Ser Ser Ser Lys Ser Asn Gly Leu Ser Lys Asp Met 
385                 390                 395                 400 


Asp Thr Gly Leu Gly Asp Ser Ile Cys Phe Ser Pro Ser Ile Ser Ser 
                405                 410                 415     


Thr Thr Ser Pro Lys Leu Asn Pro Pro Pro Ser Pro His Ala Asn Lys 
            420                 425                 430         


Lys Lys His Leu Lys Lys Lys Ser Thr Asn Asn Phe Met Ile Val Ser 
        435                 440                 445             


Ala Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr Glu Glu Arg 
    450                 455                 460                 


Asp Ala Trp Val Gln Ala Ile Gln Ser Gln Ser Glu Ala Met Ala Leu 
465                 470                 475                 480 


Gln Ser Ile Gln Asn Met Arg Gly Asn Ala His Cys Val Asp Tyr Glu 
                485                 490                 495     


Thr Gln Asn Pro Lys Trp Ala Ser Leu Asn Leu Gly Val Leu Met Cys 
            500                 505                 510         


Ile Glu Cys Ser Gly Ile His Arg Ser Leu Gly Thr Arg Leu Ser Arg 
        515                 520                 525             


Val Arg Ser Leu Glu Leu Asp Asp Trp Pro Val Glu Leu Arg Lys Val 
    530                 535                 540                 


Met Ser Ser Ile Gly Asn Asp Leu Ala Asn Ser Ile Trp Glu Gly Ser 
545                 550                 555                 560 


Ser Gln Gly Gln Thr Lys Pro Ser Val Lys Ser Thr Arg Glu Glu Lys 
                565                 570                 575     


Glu Arg Trp Ile Arg Ser Lys Tyr Glu Glu Lys Leu Phe Leu Ala Pro 
            580                 585                 590         


Leu Pro Cys Thr Glu Leu Ser Leu Gly Gln His Leu Leu Arg Ala Thr 
        595                 600                 605             


Ala Asp Glu Asp Leu Gln Thr Ala Ile Leu Leu Leu Ala His Gly Ser 
    610                 615                 620                 


Arg Glu Glu Val Asn Glu Thr Cys Gly Glu Gly Asp Gly Cys Thr Ala 
625                 630                 635                 640 


Leu His Leu Ala Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu 
                645                 650                 655     


Ile Trp Tyr Gly Val Asp Val Met Ala Arg Asp Ala His Gly Asn Thr 
            660                 665                 670         


Ala Leu Thr Tyr Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asn Val 
        675                 680                 685             


Leu Leu Gln Tyr Gly Cys Pro Asp Glu Cys Val 
    690                 695                 


<210>  4985
<211>  4474
<212>  DNA
<213>  Homosapiens

<400>  4985
aaataataat aataataata ataatctaca atgtcatttc ccatccaagc ttgacttcta     60

cctttacttt ctgatgtggt tttgccatgt ccccacccaa atctcatcat gaattataat    120

ccccataatc ctgatgtgtt gagggagggg cctaggggga ggtgatcaga tcacgggggc    180

agttatcctc atgctgttct tgtgatattc agtaagtcct catgagatct tatagggttt    240

tgttttgttt tgttttttag gatggagtct tgctctgttg tccaggcagg agtgccatgg    300

cacgatcttg gctcactgca gtctctgcct cttgagttcc agtaattctc ctgcctcagc    360

ctcctgagta gctgggatta caggcatgca ccaccacacc cagctaattt ttgtattttt    420

agtagagaca ggatttcact acattagcta ggctggtctc aaactcctga cctcagttga    480

tccacctgcc ttggcctccc aaagtactag ggttacaagt gtgagccacc atgcccagct    540

gagatctgat ggttttatac atgtttgaca gttgctcctt cacatgttgc cactctctgt    600

gcggccacca tgtaagtcgg acctgccctt ctgccatgat tgtaagtttc ctgaggcctc    660

cccagccatg tgaaactgag tcaattaaac ctcttccctt taaaaattac ccaacctcag    720

gtatttcttt atatcagtgt gaaaacagat tgctatactt tctgataatc atgcttaagc    780

aattggggaa ttcagactac ctgggatcaa accagggccc cacccttagc agtcatgtga    840

ccttggggag gttacttacc ttctccgtct caacaacttc tgtaaaatct gtaacatgag    900

attgtttctg agggttaaat gagcatagca cagtggggac actgtcaggc acacactact    960

tgccagatgt caagtattca tctttattga aataggactg tggtaagcca ctttatggct   1020

ctcgattctg tatgagaaaa tcatgcttag tgccttgtta gtaaaagaaa gaaaatctga   1080

aagtccctgc catggaagga agaaatagcg gggagaaaag ggagttggta agtttcagca   1140

tttcagagct tggagggaca agttaggttt ctattttatg gagaaggagg tggaggcagg   1200

atgggtccta aggtgtcatt caaaacacac agccataact ctttattgag agtagagcta   1260

gggccgcagg gattgctgtg gtcacgttgc ggacaaaaat gaccactcgt tggaagacag   1320

gagaggagtg tttagttaca aaagcagtca acaattcagg tgtatctata ttcagtcagc   1380

aaataaaagt tgttcaactt ggttgctaat gggacccact ctactgaggc tttgtataga   1440

actcatagag gaagatggct tcaagcaatg aactaccctg tgcttttctt aggactaaaa   1500

tctcaggaag ttggtgatga atgaaaacct tagtcccact ggcactgcac gaggggccag   1560

gagagcagca gcatcataag ccacagggtg gggcagccaa ggcaggggca ttctgagctg   1620

ttggggaggg gtggcaggca gggtggggca ctgtgaggtg tcggggaggg cattgtgaag   1680

tgtggggtgg ggcattctgt gccacatgcc tgggctccca cctggggcca gtgggcttca   1740

gtctgtaggt gactacagaa ggaggaggag ctccgtctgt tctctcttca ggcagttgtt   1800

gtgtctctca gcgcttgttg ggttcacaac ctattaaata agccagctgg tcttcaccct   1860

cccagacaag tcaactcagg ggaggcagca gggtgtgggc cttgacccgc agccctagcc   1920

ggggccgggg ccggggccag ggatggtgcc cggggccgcg ctgtgaggtg ggcaggcgag   1980

gagcgggaag accatctctg caagtgcagc atagcctcgg cctaggacag tgggagtgtg   2040

tggccaaagc tgtgagcaga ggcacaggtg gtggcagaca gtagaggcgc cccatgggga   2100

acatactgac ctgttgtgtg caccctagcg tcagcctcga gtttgaccag caacaggggt   2160

cggtgtgtcc ctctgaatct gagatctatg aggcaggagc tggggacagg atggcaggag   2220

cgcccatggc tgctgctgtg cagcctgctg aggtgaccgt tgaagttggt gaggacctcc   2280

acatgcacca cattcgtgac caggagatgc ctgaagcttt ggagtttagc ctttctgcca   2340

atccagaggc aagcacaata ttccagagga actctcaaac agatgctttg gagtttaacc   2400

cttctgccaa tccagaggca agcacaatat tccagaggaa ctctcaaaca gatgttgtag   2460

aaataagaag aagcaactgt acaaaccatg tatctactga gcgtttcagt caacaataca   2520

gctcgtgttc gacaatattc cttgatgaca gcacagccag ccagcattat cttacaatga   2580

caataatatc tgtgaccttg gagatacctc atcatatcac acaaagagat gcagatagat   2640

ctttgagcat acctgatgaa cagttacact catttgcggt ttccaccgtg cacattacga   2700

agaacagaaa tggaggtggg agtttaaata actattcctc ctccattcca tcgactccca   2760

gcaccagcca ggaggaccct cagttcagtg ttcctcccac tgccaacaca cccacccccg   2820

tttgcaagcg gtccatgcgc tggtccaacc tgtttacatc tgagaaaggg agtcacccag   2880

acaaagagag gaaagccccg gagaatcatg ctgacaccat cgggagcggc agagccatcc   2940

ccattaaaca gggcatgctc ttaaagcgaa gtgggaaatg gctgaagaca tggaaaaaga   3000

aatacgtcac cctgtgttcc aatggcgtgc tcacctatta ttcaagctta ggtgattata   3060

tgaagaatat tcataaaaaa gagattgacc ttcggacatc taccatcaaa gtcccaggaa   3120

agtggccatc cctagccaca tcggcctgtg cacccatctc cagctctaaa agcaatggcc   3180

tatccaagga catggacacc gggctgggtg actccatatg cttcagcccc agtatctcca   3240

gcaccaccag ccccaagctc aacccgcccc cctctcctca tgccaataaa aagaaacacc   3300

taaagaagaa aagcaccaac aactttatga ttgtgtctgc cactggccaa acatggcact   3360

ttgaagccac gacgtatgag gagcgggatg cctgggtcca agccatccag agccagatcc   3420

tggccagcct gcagtcatgc gagagcagta aaagcaagtc ccagctgacc agccagagcg   3480

aggccatggc cctgcagtcg atccaaaaca tgcgtgggaa cgcccactgt gtggactatg   3540

agacccagaa tcctaagtgg gccagtttga acttgggagt cctcatgtgt attgaatgct   3600

caggaatcca ccgcagtctt ggcacccgcc tttcccgtgt gcgatctctg gagctggatg   3660

actggccagt tgagctcagg aaggttatgt catctattgg caatgaccta gccaacagca   3720

tctgggaagg gagcagccag gggcagacaa aaccctcagt aaagtccacg agggaagaga   3780

aggaacggtg gatccgttcc aaatatgagg agaagctctt tctggcccca ctaccctgca   3840

ctgagctgtc cctgggccag cacctgctgc gggccaccgc tgatgaggac ctgcagacag   3900

ccatcctgct gctggcacat ggctcccgtg aggaggtgaa cgagacctgt ggggagggag   3960

acggctgcac ggcgctccat ctggcctgcc gcaaggggaa tgtggtcctg gcacagctcc   4020

tgatctggta cggggtggac gtcatggccc gagatgccca cgggaacaca gcgctgacct   4080

acgcccggca ggcctccagc caggagtgca tcaacgtgct tctgcagtac ggctgccccg   4140

acgagtgcgt gtagtatctg ttttatttga ctgcagtctc cttggtgcaa aaacaaaatg   4200

ggaaaaataa ggataactca gaatttcaaa aggaaatcac aaattcagct agtaatagca   4260

ttttcagtac ttttcataaa ctaagtaaat acacaaaatg ttgatttttc tgaccataag   4320

acatatttta tgtccttttg ccaaggtgga tgtgttagtc tcaggccctc ctggccacat   4380

tgcccaagtc acacaggctt ctgtattatg tatttagata aaatgtgtga aaatatattt   4440

gaaaaaaaag ttcataaata tgcattgatt tttg                               4474


<210>  4986
<211>  686
<212>  PRT
<213>  Homosapiens

<400>  4986

Met Gly Asn Ile Leu Thr Cys Cys Val His Pro Ser Val Ser Leu Glu 
1               5                   10                  15      


Phe Asp Gln Gln Gln Gly Ser Val Cys Pro Ser Glu Ser Glu Ile Tyr 
            20                  25                  30          


Glu Ala Gly Ala Gly Asp Arg Met Ala Gly Ala Pro Met Ala Ala Ala 
        35                  40                  45              


Val Gln Pro Ala Glu Val Thr Val Glu Val Gly Glu Asp Leu His Met 
    50                  55                  60                  


His His Ile Arg Asp Gln Glu Met Pro Glu Ala Leu Glu Phe Ser Leu 
65                  70                  75                  80  


Ser Ala Asn Pro Glu Ala Ser Thr Ile Phe Gln Arg Asn Ser Gln Thr 
                85                  90                  95      


Asp Ala Leu Glu Phe Asn Pro Ser Ala Asn Pro Glu Ala Ser Thr Ile 
            100                 105                 110         


Phe Gln Arg Asn Ser Gln Thr Asp Val Val Glu Ile Arg Arg Ser Asn 
        115                 120                 125             


Cys Thr Asn His Val Ser Thr Glu Arg Phe Ser Gln Gln Tyr Ser Ser 
    130                 135                 140                 


Cys Ser Thr Ile Phe Leu Asp Asp Ser Thr Ala Ser Gln His Tyr Leu 
145                 150                 155                 160 


Thr Met Thr Ile Ile Ser Val Thr Leu Glu Ile Pro His His Ile Thr 
                165                 170                 175     


Gln Arg Asp Ala Asp Arg Ser Leu Ser Ile Pro Asp Glu Gln Leu His 
            180                 185                 190         


Ser Phe Ala Val Ser Thr Val His Ile Thr Lys Asn Arg Asn Gly Gly 
        195                 200                 205             


Gly Ser Leu Asn Asn Tyr Ser Ser Ser Ile Pro Ser Thr Pro Ser Thr 
    210                 215                 220                 


Ser Gln Glu Asp Pro Gln Phe Ser Val Pro Pro Thr Ala Asn Thr Pro 
225                 230                 235                 240 


Thr Pro Val Cys Lys Arg Ser Met Arg Trp Ser Asn Leu Phe Thr Ser 
                245                 250                 255     


Glu Lys Gly Ser His Pro Asp Lys Glu Arg Lys Ala Pro Glu Asn His 
            260                 265                 270         


Ala Asp Thr Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Met 
        275                 280                 285             


Leu Leu Lys Arg Ser Gly Lys Trp Leu Lys Thr Trp Lys Lys Lys Tyr 
    290                 295                 300                 


Val Thr Leu Cys Ser Asn Gly Val Leu Thr Tyr Tyr Ser Ser Leu Gly 
305                 310                 315                 320 


Asp Tyr Met Lys Asn Ile His Lys Lys Glu Ile Asp Leu Arg Thr Ser 
                325                 330                 335     


Thr Ile Lys Val Pro Gly Lys Trp Pro Ser Leu Ala Thr Ser Ala Cys 
            340                 345                 350         


Ala Pro Ile Ser Ser Ser Lys Ser Asn Gly Leu Ser Lys Asp Met Asp 
        355                 360                 365             


Thr Gly Leu Gly Asp Ser Ile Cys Phe Ser Pro Ser Ile Ser Ser Thr 
    370                 375                 380                 


Thr Ser Pro Lys Leu Asn Pro Pro Pro Ser Pro His Ala Asn Lys Lys 
385                 390                 395                 400 


Lys His Leu Lys Lys Lys Ser Thr Asn Asn Phe Met Ile Val Ser Ala 
                405                 410                 415     


Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr Glu Glu Arg Asp 
            420                 425                 430         


Ala Trp Val Gln Ala Ile Gln Ser Gln Ile Leu Ala Ser Leu Gln Ser 
        435                 440                 445             


Cys Glu Ser Ser Lys Ser Lys Ser Gln Leu Thr Ser Gln Ser Glu Ala 
    450                 455                 460                 


Met Ala Leu Gln Ser Ile Gln Asn Met Arg Gly Asn Ala His Cys Val 
465                 470                 475                 480 


Asp Tyr Glu Thr Gln Asn Pro Lys Trp Ala Ser Leu Asn Leu Gly Val 
                485                 490                 495     


Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Ser Leu Gly Thr Arg 
            500                 505                 510         


Leu Ser Arg Val Arg Ser Leu Glu Leu Asp Asp Trp Pro Val Glu Leu 
        515                 520                 525             


Arg Lys Val Met Ser Ser Ile Gly Asn Asp Leu Ala Asn Ser Ile Trp 
    530                 535                 540                 


Glu Gly Ser Ser Gln Gly Gln Thr Lys Pro Ser Val Lys Ser Thr Arg 
545                 550                 555                 560 


Glu Glu Lys Glu Arg Trp Ile Arg Ser Lys Tyr Glu Glu Lys Leu Phe 
                565                 570                 575     


Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly Gln His Leu Leu 
            580                 585                 590         


Arg Ala Thr Ala Asp Glu Asp Leu Gln Thr Ala Ile Leu Leu Leu Ala 
        595                 600                 605             


His Gly Ser Arg Glu Glu Val Asn Glu Thr Cys Gly Glu Gly Asp Gly 
    610                 615                 620                 


Cys Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val Val Leu Ala 
625                 630                 635                 640 


Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Met Ala Arg Asp Ala His 
                645                 650                 655     


Gly Asn Thr Ala Leu Thr Tyr Ala Arg Gln Ala Ser Ser Gln Glu Cys 
            660                 665                 670         


Ile Asn Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu Cys Val 
        675                 680                 685     


<210>  4987
<211>  3766
<212>  DNA
<213>  Homosapiens

<400>  4987
ttcggtgccg cgggctgggg taggcggcag tggggtccct ggctttgggg cactgggaag     60

atcgcgagtg ggaaggtcct cccgcggtcc tccgggtcat ctttcctcct gaggagcagc    120

atatttcgca tctgccggag attagaatta cttgttattg gtaaatagcc actatggaga    180

ctaaggacca gaagaaacaa agaaagaaaa atagtggacc caaagctgca aagaaaaaga    240

agcggcatct gcaggatctc cagctaggag acgaagaaga tgcctggaag agaaatccca    300

aagcttttgc atttcagtct gctgtgtgga tggctcgatc ctttcacagg actcaggatt    360

tgaagacaaa aaagcatcat attccagtgg ttgatcgaac tccactagag cccccaccaa    420

tagtggtagt ggtgatgggg cctccaaagt tggaaagagc actttgatac aatgcctcat    480

tcggaacttc acccggcaga agttgaccga gatcagaggc cctgtgatga tcgtgtcagg    540

taaaaagctc cgactcacca ttattgaatg tgggtgtgac attaacatga tgattgatct    600

ggctgaagta gcagatctgg tactgatgct tatagatgcc agctttgggt ttgaaatgga    660

aacgtttgag tttctaaaca tctgtcaagt acatggcttt cctaaaatta tgggagttct    720

cacccacctc gacttcttca aacacaataa gcaactgaag aagacaaaga agcgattaaa    780

acacaggttc tggacagaag tttacctggt tgccaagctg ttctgccttt ctggaatggt    840

gcatggagaa tatcaaaacc aagaaatgca caatctgggc cattttatta cagttatgaa    900

gtttaggcct ctcacatggc agacttctca tccttatatc ctggcagaca gggtggaaga    960

tttgacaaac ccagaggata tccaaacaaa catcagatgt gaccagcaga tgttacttta   1020

cggttattta agaggagcgc acttgaaaaa taaaagccaa attcacatgc caggacgagg   1080

tggggcccac ccatgagctg gtccagagtc tcatctccac ccactccacc attgatgcca   1140

agatggcttc aagtcgagtg atgttgtttt ctgattccaa gccacttggg tcagaggcta   1200

tagataatca aggcgtcagc ctcgagtttg accagcaaca ggggtcggtg tgtccctctg   1260

aatctgagat ctatgaggca ggagctgggg acaggatggc aggagcgccc atggctgctg   1320

ctgtgcagcc tgctgaggtg accgttgaag ttggtgagga cctccacatg caccacattc   1380

gtgaccagga gatgcctgaa gctttggagt ttagcctttc tgccaatcca gaggcaagca   1440

caatattcca gaggaactct caaacagatg ctttggagtt taacccttct gccaatccag   1500

aggcaagcac aatattccag aggaactctc aaacagatgt tgtagaaata agaagaagca   1560

actgtacaaa ccatgtatct actgagcgtt tcagtcaaca atacagctcg tgttcgacaa   1620

tattccttga tgacagcaca gccagccagc attatcttac aatgacaata atatctgtga   1680

ccttggagat acctcatcat atcacacaaa gagatgcaga tagatctttg agcatacctg   1740

atgaacagtt acactcattt gcgggtttca ccatgttggc caggatggtc ttgaactcct   1800

gacctcgtga tccacccacc ttggcctccc aaagtgctgt gattacaggt gtgagccacc   1860

atgcctggcc cagaaaatgt atctttttaa aaggtaattg taagctgtct ataggaccct   1920

gcaagccact acccaatttt tgaagccatt cctccttctg ttccacacag gtttccaccg   1980

tgcacattac gaagaacaga aatggaggtg ggagtttaaa taactattcc tcctccattc   2040

catcgactcc cagcaccagc caggaggacc ctcagttcag tgttcctccc actgccaaca   2100

cacccacccc cgtttgcaag cggtccatgc gctggtccaa cctgtttaca tctgagaaag   2160

ggagtcaccc agacaaagag aggaaagccc cggagaatca tgctgacacc atcgggagcg   2220

gcagagccat ccccattaaa cagggcatgc tcttaaagcg aagtgggaaa tggctgaaga   2280

catggaaaaa gaaatacgtc accctgtgtt ccaatggcgt gctcacctat tattcaagct   2340

taggtgatta tatgaagaat attcataaaa aagagattga ccttcggaca tctaccatca   2400

aagtcccagg aaagtggcca tccctagcca catcggcctg tgcacccatc tccagctcta   2460

aaagcaatgg cctatccaag gacatggaca ccgggctggg tgactccata tgcttcagcc   2520

ccagtatctc cagcaccacc agccccaagc tcaacccgcc cccctctcct catgccaata   2580

aaaagaaaca cctaaagaag aaaagcacca acaactttat gattgtgtct gccactggcc   2640

aaacatggca ctttgaagcc acgacgtatg aggagcggga tgcctgggtc caagccatcc   2700

agagccagat cctggccagc ctgcagtcat gcgagagcag taaaagcaag tcccagctga   2760

ccagccagag cgaggccatg gccctgcagt cgatccaaaa catgcgtggg aacgcccact   2820

gtgtggacta tgagacccag aatcctaagt gggccagttt gaacttggga gtcctcatgt   2880

gtattgaatg ctcaggaatc caccgcagtc ttggcacccg cctttcccgt gtgcgatctc   2940

tggagctgga tgactggcca gttgagctca ggaaggttat gtcatctatt ggcaatgacc   3000

tagccaacag catctgggaa gggagcagcc aggggcagac aaaaccctca gtaaagtcca   3060

cgagggaaga gaaggaacgg tggatccgtt ccaaatatga ggagaagctc tttctggccc   3120

cactaccctg cactgagctg tccctgggcc agcacctgct gcgggccacc gctgatgagg   3180

acctgcagac agccatcctg ctgctggcac atggctcccg tgaggaggtg aacgagacct   3240

gtggggaggg agacggctgc acggcgctcc atctggcctg ccgcaagggg aatgtggtcc   3300

tggcacagct cctgatctgg tacggggtgg acgtcatggc ccgagatgcc cacgggaaca   3360

cagcgctgac ctacgcccgg caggcctcca gccaggagtg catcaacgtg cttctgcagt   3420

acggctgccc cgacgagtgc gtgtagtatc tgttttattt gactgcagtc tccttggtgc   3480

aaaaacaaaa tgggaaaaat aaggataact cagaatttca aaaggaaatc acaaattcag   3540

ctagtaatag cattttcagt acttttcata aactaagtaa atacacaaaa tgttgatttt   3600

tctgaccata agacatattt tatgtccttt tgccaaggtg gatgtgttag tctcaggccc   3660

tcctggccac attgcccaag tcacacaggc ttctgtatta tgtatttaga taaaatgtgt   3720

gaaaatatat ttgaaaaaaa agttcataaa tatgcattga tttttg                  3766


<210>  4988
<211>  439
<212>  PRT
<213>  Homosapiens

<400>  4988

Met Arg Trp Ser Asn Leu Phe Thr Ser Glu Lys Gly Ser His Pro Asp 
1               5                   10                  15      


Lys Glu Arg Lys Ala Pro Glu Asn His Ala Asp Thr Ile Gly Ser Gly 
            20                  25                  30          


Arg Ala Ile Pro Ile Lys Gln Gly Met Leu Leu Lys Arg Ser Gly Lys 
        35                  40                  45              


Trp Leu Lys Thr Trp Lys Lys Lys Tyr Val Thr Leu Cys Ser Asn Gly 
    50                  55                  60                  


Val Leu Thr Tyr Tyr Ser Ser Leu Gly Asp Tyr Met Lys Asn Ile His 
65                  70                  75                  80  


Lys Lys Glu Ile Asp Leu Arg Thr Ser Thr Ile Lys Val Pro Gly Lys 
                85                  90                  95      


Trp Pro Ser Leu Ala Thr Ser Ala Cys Ala Pro Ile Ser Ser Ser Lys 
            100                 105                 110         


Ser Asn Gly Leu Ser Lys Asp Met Asp Thr Gly Leu Gly Asp Ser Ile 
        115                 120                 125             


Cys Phe Ser Pro Ser Ile Ser Ser Thr Thr Ser Pro Lys Leu Asn Pro 
    130                 135                 140                 


Pro Pro Ser Pro His Ala Asn Lys Lys Lys His Leu Lys Lys Lys Ser 
145                 150                 155                 160 


Thr Asn Asn Phe Met Ile Val Ser Ala Thr Gly Gln Thr Trp His Phe 
                165                 170                 175     


Glu Ala Thr Thr Tyr Glu Glu Arg Asp Ala Trp Val Gln Ala Ile Gln 
            180                 185                 190         


Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser Lys Ser Lys 
        195                 200                 205             


Ser Gln Leu Thr Ser Gln Ser Glu Ala Met Ala Leu Gln Ser Ile Gln 
    210                 215                 220                 


Asn Met Arg Gly Asn Ala His Cys Val Asp Tyr Glu Thr Gln Asn Pro 
225                 230                 235                 240 


Lys Trp Ala Ser Leu Asn Leu Gly Val Leu Met Cys Ile Glu Cys Ser 
                245                 250                 255     


Gly Ile His Arg Ser Leu Gly Thr Arg Leu Ser Arg Val Arg Ser Leu 
            260                 265                 270         


Glu Leu Asp Asp Trp Pro Val Glu Leu Arg Lys Val Met Ser Ser Ile 
        275                 280                 285             


Gly Asn Asp Leu Ala Asn Ser Ile Trp Glu Gly Ser Ser Gln Gly Gln 
    290                 295                 300                 


Thr Lys Pro Ser Val Lys Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile 
305                 310                 315                 320 


Arg Ser Lys Tyr Glu Glu Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr 
                325                 330                 335     


Glu Leu Ser Leu Gly Gln His Leu Leu Arg Ala Thr Ala Asp Glu Asp 
            340                 345                 350         


Leu Gln Thr Ala Ile Leu Leu Leu Ala His Gly Ser Arg Glu Glu Val 
        355                 360                 365             


Asn Glu Thr Cys Gly Glu Gly Asp Gly Cys Thr Ala Leu His Leu Ala 
    370                 375                 380                 


Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly 
385                 390                 395                 400 


Val Asp Val Met Ala Arg Asp Ala His Gly Asn Thr Ala Leu Thr Tyr 
                405                 410                 415     


Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asn Val Leu Leu Gln Tyr 
            420                 425                 430         


Gly Cys Pro Asp Glu Cys Val 
        435                 


<210>  4989
<211>  3842
<212>  DNA
<213>  Homosapiens

<400>  4989
tccgacctga ggagtcacag ttgtgagcaa gttcggtgcc gcgggctggg attagaatta     60

cttgttattg gtaaatagcc actatggaga ctaaggacca gaagaaacaa agaaagaaaa    120

atagtggacc caaagctgca aagaaaaaga agcggcatct gcaggatctc cagctaggag    180

acgaagaaga tgcctggaag agaaatccca aagcttttgc atttcagtct gctgtgtgga    240

tggctcgatc ctttcacagg actcaggatt tgaagacaaa aaagcatcat attccagtgg    300

ttgatcgaac tccactagag cccccaccaa tagtggtagt ggtgatgggg cctccaaagt    360

tggaaagagc actttgatac aatgcctcat tcggaacttc acccggcaga agttgaccga    420

gatcagaggc cctgtgatga tcgtgtcagg taaaaagctc cgactcacca ttattgaatg    480

tgggtgtgac attaacatga tgattgatct ggctgaagta gcagatctgg tactgatgct    540

tatagatgcc agctttgggt ttgaaatgga aacgtttgag tttctaaaca tctgtcaagt    600

acatggcttt cctaaaatta tgggagttct cacccacctc gacttcttca aacacaataa    660

gcaactgaag aagacaaaga agcgattaaa acacaggttc tggacagaag tttacctggt    720

tgccaagctg ttctgccttt ctggaatggt gcatggagaa tatcaaaacc aagaaatgca    780

caatctgggc cattttatta cagttatgaa gtttaggcct ctcacatggc agacttctca    840

tccttatatc ctggcagaca gggtggaaga tttgacaaac ccagaggata tccaaacaaa    900

catcagatgt gaccagcaga tgttacttta cggttattta agaggagcgc acttgaaaaa    960

taaaagccaa attcacatgc caggacgagg tggggcccac ccatgagctg gtccagagtc   1020

tcatctccac ccactccacc attgatgcca agatggcttc aagtcgagtg atgttgtttt   1080

ctgattccaa gccacttggg tcagaggcta tagataatca aggggacgag ttctcactat   1140

gttgcccagg ctggcctcga actcctgggc tcaagcaatc ctcctgcgtt ggcctcccaa   1200

agtcctggga ttacaggtgt aagccactac ggctggccta ttattgctgt attctaactt   1260

attcatctcc tatgtgtcag agatggcttt ggattccccg ttctgtgtgc tgctgtctgg   1320

ctcctgaacc cagctgtaga ggtgtgtcaa tcccaactgg tgaagtactg agaggaagct   1380

acacaaaagg cagcaaagta ttagtgagtg gtgtcattga gcaaacacga agtcgggctc   1440

atccaaggat gagattttgc cagagaaagg acgagcagca agtcagggag cttaagcgtc   1500

agcctcgagt ttgaccagca acaggggtcg gtgtgtccct ctgaatctga gatctatgag   1560

gcaggagctg gggacaggat ggcaggagcg cccatggctg ctgctgtgca gcctgctgag   1620

gtgaccgttg aagttggtga ggacctccac atgcaccaca ttcgtgacca ggagatgcct   1680

gaagctttgg agtttagcct ttctgccaat ccagaggcaa gcacaatatt ccagaggaac   1740

tctcaaacag atgctttgga gtttaaccct tctgccaatc cagaggcaag cacaatattc   1800

cagaggaact ctcaaacaga tgttgtagaa ataagaagaa gcaactgtac aaaccatgta   1860

tctactgagc gtttcagtca acaatacagc tcgtgttcga caatattcct tgatgacagc   1920

acagccagcc agcattatct tacaatgaca ataatatctg tgaccttgga gatacctcat   1980

catatcacac aaagagatgc agatagatct ttgagcatac ctgatgaaca gttacactca   2040

tttgcggttt ccaccgtgca cattacgaag aacagaaatg gaggtgggag tttaaataac   2100

tattcctcct ccattccatc gactcccagc accagccagg aggaccctca gttcagtgtt   2160

cctcccactg ccaacacacc cacccccgtt tgcaagcggt ccatgcgctg gtccaacctg   2220

tttacatctg agaaagggag tcacccagac aaagagagga aagccccgga gaatcatgct   2280

gacaccatcg ggagcggcag agccatcccc attaaacagg gcatgctctt aaagcgaagt   2340

gggaaatggc tgaagacatg gaaaaagaaa tacgtcaccc tgtgttccaa tggcgtgctc   2400

acctattatt caagcttagg tgattatatg aagaatattc ataaaaaaga gattgacctt   2460

cggacatcta ccatcaaagt cccaggaaag tggccatccc tagccacatc ggcctgtgca   2520

cccatctcca gctctaaaag caatggccta tccaaggaca tggacaccgg gctgggtgac   2580

tccatatgct tcagccccag tatctccagc accaccagcc ccaagctcaa cccgcccccc   2640

tctcctcatg ccaataaaaa gaaacaccta aagaagaaaa gcaccaacaa ctttatgatt   2700

gtgtctgcca ctggccaaac atggcacttt gaagccacga cgtatgagga gcgggatgcc   2760

tgggtccaag ccatccagag ccagatcctg gccagcctgc agtcatgcga gagcagtaaa   2820

agcaagtccc agctgaccag ccagagcgag gccatggccc tgcagtcgat ccaaaacatg   2880

cgtgggaacg cccactgtgt ggactatgag acccagaatc ctaagtgggc cagtttgaac   2940

ttgggagtcc tcatgtgtat tgaatgctca ggaatccacc gcagtcttgg cacccgcctt   3000

tcccgtgtgc gatctctgga gctggatgac tggccagttg agctcaggaa ggttatgtca   3060

tctattggca atgacctagc caacagcatc tgggaaggga gcagccaggg gcagacaaaa   3120

ccctcagtaa agtccacgag ggaagagaag gaacggtgga tccgttccaa atatgaggag   3180

aagctctttc tggccccact accctgcact gagctgtccc tgggccagca cctgctgcgg   3240

gccaccgctg atgaggacct gcagacagcc atcctgctgc tggcacatgg ctcccgtgag   3300

gaggtgaacg agacctgtgg ggagggagac ggctgcacgg cgctccatct ggcctgccgc   3360

aaggggaatg tggtcctggc acagctcctg atctggtacg gggtggacgt catggcccga   3420

gatgcccacg ggaacacagc gctgacctac gcccggcagg cctccagcca ggagtgcatc   3480

aacgtgcttc tgcagtacgg ctgccccgac gagtgcgtgt agtatctgtt ttatttgact   3540

gcagtctcct tggtgcaaaa acaaaatggg aaaaataagg ataactcaga atttcaaaag   3600

gaaatcacaa attcagctag taatagcatt ttcagtactt ttcataaact aagtaaatac   3660

acaaaatgtt gatttttctg accataagac atattttatg tccttttgcc aaggtggatg   3720

tgttagtctc aggccctcct ggccacattg cccaagtcac acaggcttct gtattatgta   3780

tttagataaa atgtgtgaaa atatatttga aaaaaaagtt cataaatatg cattgatttt   3840

tg                                                                  3842


<210>  4990
<211>  642
<212>  PRT
<213>  Homosapiens

<400>  4990

Met Ala Ala Ala Val Gln Pro Ala Glu Val Thr Val Glu Val Gly Glu 
1               5                   10                  15      


Asp Leu His Met His His Ile Arg Asp Gln Glu Met Pro Glu Ala Leu 
            20                  25                  30          


Glu Phe Ser Leu Ser Ala Asn Pro Glu Ala Ser Thr Ile Phe Gln Arg 
        35                  40                  45              


Asn Ser Gln Thr Asp Ala Leu Glu Phe Asn Pro Ser Ala Asn Pro Glu 
    50                  55                  60                  


Ala Ser Thr Ile Phe Gln Arg Asn Ser Gln Thr Asp Val Val Glu Ile 
65                  70                  75                  80  


Arg Arg Ser Asn Cys Thr Asn His Val Ser Thr Glu Arg Phe Ser Gln 
                85                  90                  95      


Gln Tyr Ser Ser Cys Ser Thr Ile Phe Leu Asp Asp Ser Thr Ala Ser 
            100                 105                 110         


Gln His Tyr Leu Thr Met Thr Ile Ile Ser Val Thr Leu Glu Ile Pro 
        115                 120                 125             


His His Ile Thr Gln Arg Asp Ala Asp Arg Ser Leu Ser Ile Pro Asp 
    130                 135                 140                 


Glu Gln Leu His Ser Phe Ala Val Ser Thr Val His Ile Thr Lys Asn 
145                 150                 155                 160 


Arg Asn Gly Gly Gly Ser Leu Asn Asn Tyr Ser Ser Ser Ile Pro Ser 
                165                 170                 175     


Thr Pro Ser Thr Ser Gln Glu Asp Pro Gln Phe Ser Val Pro Pro Thr 
            180                 185                 190         


Ala Asn Thr Pro Thr Pro Val Cys Lys Arg Ser Met Arg Trp Ser Asn 
        195                 200                 205             


Leu Phe Thr Ser Glu Lys Gly Ser His Pro Asp Lys Glu Arg Lys Ala 
    210                 215                 220                 


Pro Glu Asn His Ala Asp Thr Ile Gly Ser Gly Arg Ala Ile Pro Ile 
225                 230                 235                 240 


Lys Gln Gly Met Leu Leu Lys Arg Ser Gly Lys Trp Leu Lys Thr Trp 
                245                 250                 255     


Lys Lys Lys Tyr Val Thr Leu Cys Ser Asn Gly Val Leu Thr Tyr Tyr 
            260                 265                 270         


Ser Ser Leu Gly Asp Tyr Met Lys Asn Ile His Lys Lys Glu Ile Asp 
        275                 280                 285             


Leu Arg Thr Ser Thr Ile Lys Val Pro Gly Lys Trp Pro Ser Leu Ala 
    290                 295                 300                 


Thr Ser Ala Cys Ala Pro Ile Ser Ser Ser Lys Ser Asn Gly Leu Ser 
305                 310                 315                 320 


Lys Asp Met Asp Thr Gly Leu Gly Asp Ser Ile Cys Phe Ser Pro Ser 
                325                 330                 335     


Ile Ser Ser Thr Thr Ser Pro Lys Leu Asn Pro Pro Pro Ser Pro His 
            340                 345                 350         


Ala Asn Lys Lys Lys His Leu Lys Lys Lys Ser Thr Asn Asn Phe Met 
        355                 360                 365             


Ile Val Ser Ala Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr 
    370                 375                 380                 


Glu Glu Arg Asp Ala Trp Val Gln Ala Ile Gln Ser Gln Ile Leu Ala 
385                 390                 395                 400 


Ser Leu Gln Ser Cys Glu Ser Ser Lys Ser Lys Ser Gln Leu Thr Ser 
                405                 410                 415     


Gln Ser Glu Ala Met Ala Leu Gln Ser Ile Gln Asn Met Arg Gly Asn 
            420                 425                 430         


Ala His Cys Val Asp Tyr Glu Thr Gln Asn Pro Lys Trp Ala Ser Leu 
        435                 440                 445             


Asn Leu Gly Val Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Ser 
    450                 455                 460                 


Leu Gly Thr Arg Leu Ser Arg Val Arg Ser Leu Glu Leu Asp Asp Trp 
465                 470                 475                 480 


Pro Val Glu Leu Arg Lys Val Met Ser Ser Ile Gly Asn Asp Leu Ala 
                485                 490                 495     


Asn Ser Ile Trp Glu Gly Ser Ser Gln Gly Gln Thr Lys Pro Ser Val 
            500                 505                 510         


Lys Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile Arg Ser Lys Tyr Glu 
        515                 520                 525             


Glu Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly 
    530                 535                 540                 


Gln His Leu Leu Arg Ala Thr Ala Asp Glu Asp Leu Gln Thr Ala Ile 
545                 550                 555                 560 


Leu Leu Leu Ala His Gly Ser Arg Glu Glu Val Asn Glu Thr Cys Gly 
                565                 570                 575     


Glu Gly Asp Gly Cys Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn 
            580                 585                 590         


Val Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Met Ala 
        595                 600                 605             


Arg Asp Ala His Gly Asn Thr Ala Leu Thr Tyr Ala Arg Gln Ala Ser 
    610                 615                 620                 


Ser Gln Glu Cys Ile Asn Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu 
625                 630                 635                 640 


Cys Val 
        


<210>  4991
<211>  1867
<212>  DNA
<213>  Homosapiens

<400>  4991
gcactttctt attttataga gatgcagata gatctttgag catacctgat gaacagttac     60

actcatttgc ggtttccacc gtgcacatta cgaagaacag aaatggaggt gggagtttaa    120

ataactattc ctcctccatt ccatcgactc ccagcaccag ccaggaggac cctcagttca    180

gtgttcctcc cactgccaac acacccaccc ccgtttgcaa gcggtccatg cgctggtcca    240

acctgtttac atctgagaaa gggagtcacc cagacaaaga gaggaaagcc ccggagaatc    300

atgctgacac catcgggagc ggcagagcca tccccattaa acagggcatg ctcttaaagc    360

gaagtgggaa atggctgaag acatggaaaa agaaatacgt caccctgtgt tccaatggcg    420

tgctcaccta ttattcaagc ttaggtgatt atatgaagaa tattcataaa aaagagattg    480

accttcggac atctaccatc aaagtcccag gaaagtggcc atccctagcc acatcggcct    540

gtgcacccat ctccagctct aaaagcaatg gcctatccaa ggacatggac accgggctgg    600

gtgactccat atgcttcagc cccagtatct ccagcaccac cagccccaag ctcaacccgc    660

ccccctctcc tcatgccaat aaaaagaaac acctaaagaa gaaaagcacc aacaacttta    720

tgattgtgtc tgccactggc caaacatggc actttgaagc cacgacgtat gaggagcggg    780

atgcctgggt ccaagccatc cagagccaga tcctggccag cctgcagtca tgcgagagca    840

gtaaaagcaa gtcccagctg accagccaga gcgaggccat ggccctgcag tcgatccaaa    900

acatgcgtgg gaacgcccac tgtgtggact atgagaccca gaatcctaag tgggccagtt    960

tgaacttggg agtcctcatg tgtattgaat gctcaggaat ccaccgcagt cttggcaccc   1020

gcctttcccg tgtgcgatct ctggagctgg atgactggcc agttgagctc aggaaggtta   1080

tgtcatctat tggcaatgac ctagccaaca gcatctggga agggagcagc caggggcaga   1140

caaaaccctc agtaaagtcc acgagggaag agaaggaacg gtggatccgt tccaaatatg   1200

aggagaagct ctttctggcc ccactaccct gcactgagct gtccctgggc cagcacctgc   1260

tgcgggccac cgctgatgag gacctgcaga cagccatcct gctgctggca catggctccc   1320

gtgaggaggt gaacgagacc tgtggggagg gagacggctg cacggcgctc catctggcct   1380

gccgcaaggg gaatgtggtc ctggcacagc tcctgatctg gtacggggtg gacgtcatgg   1440

cccgagatgc ccacgggaac acagcgctga cctacgcccg gcaggcctcc agccaggagt   1500

gcatcaacgt gcttctgcag tacggctgcc ccgacgagtg cgtgtagtat ctgttttatt   1560

tgactgcagt ctccttggtg caaaaacaaa atgggaaaaa taaggataac tcagaatttc   1620

aaaaggaaat cacaaattca gctagtaata gcattttcag tacttttcat aaactaagta   1680

aatacacaaa atgttgattt ttctgaccat aagacatatt ttatgtcctt ttgccaaggt   1740

ggatgtgtta gtctcaggcc ctcctggcca cattgcccaa gtcacacagg cttctgtatt   1800

atgtatttag ataaaatgtg tgaaaatata tttgaaaaaa aagttcataa atatgcattg   1860

atttttg                                                             1867


<210>  4992
<211>  439
<212>  PRT
<213>  Homosapiens

<400>  4992

Met Arg Trp Ser Asn Leu Phe Thr Ser Glu Lys Gly Ser His Pro Asp 
1               5                   10                  15      


Lys Glu Arg Lys Ala Pro Glu Asn His Ala Asp Thr Ile Gly Ser Gly 
            20                  25                  30          


Arg Ala Ile Pro Ile Lys Gln Gly Met Leu Leu Lys Arg Ser Gly Lys 
        35                  40                  45              


Trp Leu Lys Thr Trp Lys Lys Lys Tyr Val Thr Leu Cys Ser Asn Gly 
    50                  55                  60                  


Val Leu Thr Tyr Tyr Ser Ser Leu Gly Asp Tyr Met Lys Asn Ile His 
65                  70                  75                  80  


Lys Lys Glu Ile Asp Leu Arg Thr Ser Thr Ile Lys Val Pro Gly Lys 
                85                  90                  95      


Trp Pro Ser Leu Ala Thr Ser Ala Cys Ala Pro Ile Ser Ser Ser Lys 
            100                 105                 110         


Ser Asn Gly Leu Ser Lys Asp Met Asp Thr Gly Leu Gly Asp Ser Ile 
        115                 120                 125             


Cys Phe Ser Pro Ser Ile Ser Ser Thr Thr Ser Pro Lys Leu Asn Pro 
    130                 135                 140                 


Pro Pro Ser Pro His Ala Asn Lys Lys Lys His Leu Lys Lys Lys Ser 
145                 150                 155                 160 


Thr Asn Asn Phe Met Ile Val Ser Ala Thr Gly Gln Thr Trp His Phe 
                165                 170                 175     


Glu Ala Thr Thr Tyr Glu Glu Arg Asp Ala Trp Val Gln Ala Ile Gln 
            180                 185                 190         


Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser Lys Ser Lys 
        195                 200                 205             


Ser Gln Leu Thr Ser Gln Ser Glu Ala Met Ala Leu Gln Ser Ile Gln 
    210                 215                 220                 


Asn Met Arg Gly Asn Ala His Cys Val Asp Tyr Glu Thr Gln Asn Pro 
225                 230                 235                 240 


Lys Trp Ala Ser Leu Asn Leu Gly Val Leu Met Cys Ile Glu Cys Ser 
                245                 250                 255     


Gly Ile His Arg Ser Leu Gly Thr Arg Leu Ser Arg Val Arg Ser Leu 
            260                 265                 270         


Glu Leu Asp Asp Trp Pro Val Glu Leu Arg Lys Val Met Ser Ser Ile 
        275                 280                 285             


Gly Asn Asp Leu Ala Asn Ser Ile Trp Glu Gly Ser Ser Gln Gly Gln 
    290                 295                 300                 


Thr Lys Pro Ser Val Lys Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile 
305                 310                 315                 320 


Arg Ser Lys Tyr Glu Glu Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr 
                325                 330                 335     


Glu Leu Ser Leu Gly Gln His Leu Leu Arg Ala Thr Ala Asp Glu Asp 
            340                 345                 350         


Leu Gln Thr Ala Ile Leu Leu Leu Ala His Gly Ser Arg Glu Glu Val 
        355                 360                 365             


Asn Glu Thr Cys Gly Glu Gly Asp Gly Cys Thr Ala Leu His Leu Ala 
    370                 375                 380                 


Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly 
385                 390                 395                 400 


Val Asp Val Met Ala Arg Asp Ala His Gly Asn Thr Ala Leu Thr Tyr 
                405                 410                 415     


Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asn Val Leu Leu Gln Tyr 
            420                 425                 430         


Gly Cys Pro Asp Glu Cys Val 
        435                 


<210>  4993
<211>  2288
<212>  DNA
<213>  Homosapiens

<400>  4993
gctcgtgttc gacaatattc cttgatgaca gcacagccag ccagcattat cttacaatga     60

caataatatc gcactgagaa gccttttagg aaaatcagga tggatgtgag gcatctttct    120

gtgaagaaaa gcatcccaga agattctgat tttcacccca gctcaatcat tccaaacttt    180

gctgctgatt gaaatcacct gggaaacgtt taccaagaac cttgatgccc aaagccatac    240

ccaatactaa ttaaattaaa atgtctcatg tggaagatga ggcagatatt aaagcttctc    300

aggcgatttt aatgtgcagc aaagtttgag agccactgct taatttgagt ttaggacgag    360

aaactgctcc tatttggtgg gaccttgggc aagtcagttt taagtgtgac cttggagata    420

cctcatcata tcacacaaag agatgcagat agatctttga gcatacctga tgaacagtta    480

cactcatttg cggtttccac cgtgcacatt acgaagaaca gaaatggagg tgggagttta    540

aataactatt cctcctccat tccatcgact cccagcacca gccaggagga ccctcagttc    600

agtgttcctc ccactgccaa cacacccacc cccgtttgca agcggtccat gcgctggtcc    660

aacctgttta catctgagaa agggagtcac ccagacaaag agaggaaagc cccggagaat    720

catgctgaca ccatcgggag cggcagagcc atccccatta aacagggcat gctcttaaag    780

cgaagtggga aatggctgaa gacatggaaa aagaaatacg tcaccctgtg ttccaatggc    840

gtgctcacct attattcaag cttaggtgat tatatgaaga atattcataa aaaagagatt    900

gaccttcgga catctaccat caaagtccca ggaaagtggc catccctagc cacatcggcc    960

tgtgcaccca tctccagctc taaaagcaat ggcctatcca aggacatgga caccgggctg   1020

ggtgactcca tatgcttcag ccccagtatc tccagcacca ccagccccaa gctcaacccg   1080

cccccctctc ctcatgccaa taaaaagaaa cacctaaaga agaaaagcac caacaacttt   1140

atgattgtgt ctgccactgg ccaaacatgg cactttgaag ccacgacgta tgaggagcgg   1200

gatgcctggg tccaagccat ccagagccag atcctggcca gcctgcagtc atgcgagagc   1260

agtaaaagca agtcccagct gaccagccag agcgaggcca tggccctgca gtcgatccaa   1320

aacatgcgtg ggaacgccca ctgtgtggac tatgagaccc agaatcctaa gtgggccagt   1380

ttgaacttgg gagtcctcat gtgtattgaa tgctcaggaa tccaccgcag tcttggcacc   1440

cgcctttccc gtgtgcgatc tctggagctg gatgactggc cagttgagct caggaaggtt   1500

atgtcatcta ttggcaatga cctagccaac agcatctggg aagggagcag ccaggggcag   1560

acaaaaccct cagtaaagtc cacgagggaa gagaaggaac ggtggatccg ttccaaatat   1620

gaggagaagc tctttctggc cccactaccc tgcactgagc tgtccctggg ccagcacctg   1680

ctgcgggcca ccgctgatga ggacctgcag acagccatcc tgctgctggc acatggctcc   1740

cgtgaggagg tgaacgagac ctgtggggag ggagacggct gcacggcgct ccatctggcc   1800

tgccgcaagg ggaatgtggt cctggcacag ctcctgatct ggtacggggt ggacgtcatg   1860

gcccgagatg cccacgggaa cacagcgctg acctacgccc ggcaggcctc cagccaggag   1920

tgcatcaacg tgcttctgca gtacggctgc cccgacgagt gcgtgtagta tctgttttat   1980

ttgactgcag tctccttggt gcaaaaacaa aatgggaaaa ataaggataa ctcagaattt   2040

caaaaggaaa tcacaaattc agctagtaat agcattttca gtacttttca taaactaagt   2100

aaatacacaa aatgttgatt tttctgacca taagacatat tttatgtcct tttgccaagg   2160

tggatgtgtt agtctcaggc cctcctggcc acattgccca agtcacacag gcttctgtat   2220

tatgtattta gataaaatgt gtgaaaatat atttgaaaaa aaagttcata aatatgcatt   2280

gatttttg                                                            2288


<210>  4994
<211>  439
<212>  PRT
<213>  Homosapiens

<400>  4994

Met Arg Trp Ser Asn Leu Phe Thr Ser Glu Lys Gly Ser His Pro Asp 
1               5                   10                  15      


Lys Glu Arg Lys Ala Pro Glu Asn His Ala Asp Thr Ile Gly Ser Gly 
            20                  25                  30          


Arg Ala Ile Pro Ile Lys Gln Gly Met Leu Leu Lys Arg Ser Gly Lys 
        35                  40                  45              


Trp Leu Lys Thr Trp Lys Lys Lys Tyr Val Thr Leu Cys Ser Asn Gly 
    50                  55                  60                  


Val Leu Thr Tyr Tyr Ser Ser Leu Gly Asp Tyr Met Lys Asn Ile His 
65                  70                  75                  80  


Lys Lys Glu Ile Asp Leu Arg Thr Ser Thr Ile Lys Val Pro Gly Lys 
                85                  90                  95      


Trp Pro Ser Leu Ala Thr Ser Ala Cys Ala Pro Ile Ser Ser Ser Lys 
            100                 105                 110         


Ser Asn Gly Leu Ser Lys Asp Met Asp Thr Gly Leu Gly Asp Ser Ile 
        115                 120                 125             


Cys Phe Ser Pro Ser Ile Ser Ser Thr Thr Ser Pro Lys Leu Asn Pro 
    130                 135                 140                 


Pro Pro Ser Pro His Ala Asn Lys Lys Lys His Leu Lys Lys Lys Ser 
145                 150                 155                 160 


Thr Asn Asn Phe Met Ile Val Ser Ala Thr Gly Gln Thr Trp His Phe 
                165                 170                 175     


Glu Ala Thr Thr Tyr Glu Glu Arg Asp Ala Trp Val Gln Ala Ile Gln 
            180                 185                 190         


Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser Lys Ser Lys 
        195                 200                 205             


Ser Gln Leu Thr Ser Gln Ser Glu Ala Met Ala Leu Gln Ser Ile Gln 
    210                 215                 220                 


Asn Met Arg Gly Asn Ala His Cys Val Asp Tyr Glu Thr Gln Asn Pro 
225                 230                 235                 240 


Lys Trp Ala Ser Leu Asn Leu Gly Val Leu Met Cys Ile Glu Cys Ser 
                245                 250                 255     


Gly Ile His Arg Ser Leu Gly Thr Arg Leu Ser Arg Val Arg Ser Leu 
            260                 265                 270         


Glu Leu Asp Asp Trp Pro Val Glu Leu Arg Lys Val Met Ser Ser Ile 
        275                 280                 285             


Gly Asn Asp Leu Ala Asn Ser Ile Trp Glu Gly Ser Ser Gln Gly Gln 
    290                 295                 300                 


Thr Lys Pro Ser Val Lys Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile 
305                 310                 315                 320 


Arg Ser Lys Tyr Glu Glu Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr 
                325                 330                 335     


Glu Leu Ser Leu Gly Gln His Leu Leu Arg Ala Thr Ala Asp Glu Asp 
            340                 345                 350         


Leu Gln Thr Ala Ile Leu Leu Leu Ala His Gly Ser Arg Glu Glu Val 
        355                 360                 365             


Asn Glu Thr Cys Gly Glu Gly Asp Gly Cys Thr Ala Leu His Leu Ala 
    370                 375                 380                 


Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly 
385                 390                 395                 400 


Val Asp Val Met Ala Arg Asp Ala His Gly Asn Thr Ala Leu Thr Tyr 
                405                 410                 415     


Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asn Val Leu Leu Gln Tyr 
            420                 425                 430         


Gly Cys Pro Asp Glu Cys Val 
        435                 


<210>  4995
<211>  2234
<212>  DNA
<213>  Homosapiens

<400>  4995
aagagagaca gactctgggt caaaaaataa ataaatacat aaaataaatc gcatgggacg     60

aaaggtttca tcggtagaaa agcatataac agggaaatct gttattattt atatattgta    120

atcaccaaca gaaacgcgtc ttctaacggc atatttcctt gcattttggt tctcatattt    180

ttgtaaaaaa caaagaaatg aaaacaaagt gcccttatgg tactgttctg aactagaaga    240

tttgaatttc agggccgcta ggagagtttc ctctgccccc cttttaaaaa atgtcttcag    300

gcctaacaaa tgataacatc tattgttatg aatttttttt ccttccacag tgtgaccttg    360

gagatacctc atcatatcac acaaagagat gcagatagat ctttgagcat acctgatgaa    420

cagttacact catttgcggt ttccaccgtg cacattacga agaacagaaa tggaggtggg    480

agtttaaata actattcctc ctccattcca tcgactccca gcaccagcca ggaggaccct    540

cagttcagtg ttcctcccac tgccaacaca cccacccccg tttgcaagcg gtccatgcgc    600

tggtccaacc tgtttacatc tgagaaaggg agtcacccag acaaagagag gaaagccccg    660

gagaatcatg ctgacaccat cgggagcggc agagccatcc ccattaaaca gggcatgctc    720

ttaaagcgaa gtgggaaatg gctgaagaca tggaaaaaga aatacgtcac cctgtgttcc    780

aatggcgtgc tcacctatta ttcaagctta ggtgattata tgaagaatat tcataaaaaa    840

gagattgacc ttcggacatc taccatcaaa gtcccaggaa agtggccatc cctagccaca    900

tcggcctgtg cacccatctc cagctctaaa agcaatggcc tatccaagga catggacacc    960

gggctgggtg actccatatg cttcagcccc agtatctcca gcaccaccag ccccaagctc   1020

aacccgcccc cctctcctca tgccaataaa aagaaacacc taaagaagaa aagcaccaac   1080

aactttatga ttgtgtctgc cactggccaa acatggcact ttgaagccac gacgtatgag   1140

gagcgggatg cctgggtcca agccatccag agccagatcc tggccagcct gcagtcatgc   1200

gagagcagta aaagcaagtc ccagctgacc agccagagcg aggccatggc cctgcagtcg   1260

atccaaaaca tgcgtgggaa cgcccactgt gtggactatg agacccagaa tcctaagtgg   1320

gccagtttga acttgggagt cctcatgtgt attgaatgct caggaatcca ccgcagtctt   1380

ggcacccgcc tttcccgtgt gcgatctctg gagctggatg actggccagt tgagctcagg   1440

aaggttatgt catctattgg caatgaccta gccaacagca tctgggaagg gagcagccag   1500

gggcagacaa aaccctcagt aaagtccacg agggaagaga aggaacggtg gatccgttcc   1560

aaatatgagg agaagctctt tctggcccca ctaccctgca ctgagctgtc cctgggccag   1620

cacctgctgc gggccaccgc tgatgaggac ctgcagacag ccatcctgct gctggcacat   1680

ggctcccgtg aggaggtgaa cgagacctgt ggggagggag acggctgcac ggcgctccat   1740

ctggcctgcc gcaaggggaa tgtggtcctg gcacagctcc tgatctggta cggggtggac   1800

gtcatggccc gagatgccca cgggaacaca gcgctgacct acgcccggca ggcctccagc   1860

caggagtgca tcaacgtgct tctgcagtac ggctgccccg acgagtgcgt gtagtatctg   1920

ttttatttga ctgcagtctc cttggtgcaa aaacaaaatg ggaaaaataa ggataactca   1980

gaatttcaaa aggaaatcac aaattcagct agtaatagca ttttcagtac ttttcataaa   2040

ctaagtaaat acacaaaatg ttgatttttc tgaccataag acatatttta tgtccttttg   2100

ccaaggtgga tgtgttagtc tcaggccctc ctggccacat tgcccaagtc acacaggctt   2160

ctgtattatg tatttagata aaatgtgtga aaatatattt gaaaaaaaag ttcataaata   2220

tgcattgatt tttg                                                     2234


<210>  4996
<211>  528
<212>  PRT
<213>  Homosapiens

<400>  4996

Met Asn Phe Phe Ser Phe His Ser Val Thr Leu Glu Ile Pro His His 
1               5                   10                  15      


Ile Thr Gln Arg Asp Ala Asp Arg Ser Leu Ser Ile Pro Asp Glu Gln 
            20                  25                  30          


Leu His Ser Phe Ala Val Ser Thr Val His Ile Thr Lys Asn Arg Asn 
        35                  40                  45              


Gly Gly Gly Ser Leu Asn Asn Tyr Ser Ser Ser Ile Pro Ser Thr Pro 
    50                  55                  60                  


Ser Thr Ser Gln Glu Asp Pro Gln Phe Ser Val Pro Pro Thr Ala Asn 
65                  70                  75                  80  


Thr Pro Thr Pro Val Cys Lys Arg Ser Met Arg Trp Ser Asn Leu Phe 
                85                  90                  95      


Thr Ser Glu Lys Gly Ser His Pro Asp Lys Glu Arg Lys Ala Pro Glu 
            100                 105                 110         


Asn His Ala Asp Thr Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln 
        115                 120                 125             


Gly Met Leu Leu Lys Arg Ser Gly Lys Trp Leu Lys Thr Trp Lys Lys 
    130                 135                 140                 


Lys Tyr Val Thr Leu Cys Ser Asn Gly Val Leu Thr Tyr Tyr Ser Ser 
145                 150                 155                 160 


Leu Gly Asp Tyr Met Lys Asn Ile His Lys Lys Glu Ile Asp Leu Arg 
                165                 170                 175     


Thr Ser Thr Ile Lys Val Pro Gly Lys Trp Pro Ser Leu Ala Thr Ser 
            180                 185                 190         


Ala Cys Ala Pro Ile Ser Ser Ser Lys Ser Asn Gly Leu Ser Lys Asp 
        195                 200                 205             


Met Asp Thr Gly Leu Gly Asp Ser Ile Cys Phe Ser Pro Ser Ile Ser 
    210                 215                 220                 


Ser Thr Thr Ser Pro Lys Leu Asn Pro Pro Pro Ser Pro His Ala Asn 
225                 230                 235                 240 


Lys Lys Lys His Leu Lys Lys Lys Ser Thr Asn Asn Phe Met Ile Val 
                245                 250                 255     


Ser Ala Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr Glu Glu 
            260                 265                 270         


Arg Asp Ala Trp Val Gln Ala Ile Gln Ser Gln Ile Leu Ala Ser Leu 
        275                 280                 285             


Gln Ser Cys Glu Ser Ser Lys Ser Lys Ser Gln Leu Thr Ser Gln Ser 
    290                 295                 300                 


Glu Ala Met Ala Leu Gln Ser Ile Gln Asn Met Arg Gly Asn Ala His 
305                 310                 315                 320 


Cys Val Asp Tyr Glu Thr Gln Asn Pro Lys Trp Ala Ser Leu Asn Leu 
                325                 330                 335     


Gly Val Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Ser Leu Gly 
            340                 345                 350         


Thr Arg Leu Ser Arg Val Arg Ser Leu Glu Leu Asp Asp Trp Pro Val 
        355                 360                 365             


Glu Leu Arg Lys Val Met Ser Ser Ile Gly Asn Asp Leu Ala Asn Ser 
    370                 375                 380                 


Ile Trp Glu Gly Ser Ser Gln Gly Gln Thr Lys Pro Ser Val Lys Ser 
385                 390                 395                 400 


Thr Arg Glu Glu Lys Glu Arg Trp Ile Arg Ser Lys Tyr Glu Glu Lys 
                405                 410                 415     


Leu Phe Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly Gln His 
            420                 425                 430         


Leu Leu Arg Ala Thr Ala Asp Glu Asp Leu Gln Thr Ala Ile Leu Leu 
        435                 440                 445             


Leu Ala His Gly Ser Arg Glu Glu Val Asn Glu Thr Cys Gly Glu Gly 
    450                 455                 460                 


Asp Gly Cys Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val Val 
465                 470                 475                 480 


Leu Ala Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Met Ala Arg Asp 
                485                 490                 495     


Ala His Gly Asn Thr Ala Leu Thr Tyr Ala Arg Gln Ala Ser Ser Gln 
            500                 505                 510         


Glu Cys Ile Asn Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu Cys Val 
        515                 520                 525             


<210>  4997
<211>  4164
<212>  DNA
<213>  Homosapiens

<400>  4997
aaataataat aataataata ataatctaca atgtcatttc ccatccaagc ttgacttcta     60

cctttacttt ctgatgtggt tttgccatgt ccccacccaa atctcatcat gaattataat    120

ccccataatc ctgatgtgtt gagggagggg cctaggggga ggtgatcaga tcacgggggc    180

agttatcctc atgctgttct tgtgatattc agtaagtcct catgagatct tatagggttt    240

tgttttgttt tgttttttag gatggagtct tgctctgttg tccaggcagg agtgccatgg    300

cacgatcttg gctcactgca gtctctgcct cttgagttcc agtaattctc ctgcctcagc    360

ctcctgagta gctgggatta caggcatgca ccaccacacc cagctaattt ttgtattttt    420

agtagagaca ggatttcact acattagcta ggctggtctc aaactcctga cctcagttga    480

tccacctgcc ttggcctccc aaagtactag ggttacaagt gtgagccacc atgcccagct    540

gagatctgat ggttttatac atgtttgaca gttgctcctt cacatgttgc cactctctgt    600

gcggccacca tgtaagtcgg acctgccctt ctgccatgat tgtaagtttc ctgaggcctc    660

cccagccatg tgaaactgag tcaattaaac ctcttccctt taaaaattac ccaacctcag    720

gtatttcttt atatcagtgt gaaaacagat tgctatactt tctgataatc atgcttaagc    780

aattggggaa ttcagactac ctgggatcaa accagggccc cacccttagc agtcatgtga    840

ccttggggag gttacttacc ttctccgtct caacaacttc tgtaaaatct gtaacatgag    900

attgtttctg agggttaaat gagcatagca cagtggggac actgtcaggc acacactact    960

tgccagatgt caagtattca tctttattga aataggactg tggtaagcca ctttatggct   1020

ctcgattctg tatgagaaaa tcatgcttag tgccttgtta gtaaaagaaa gaaaatctga   1080

aagtccctgc catggaagga agaaatagcg gggagaaaag ggagttggta agtttcagca   1140

tttcagagct tggagggaca agttaggttt ctattttatg gagaaggagg tggaggcagg   1200

atgggtccta aggtgtcatt caaaacacac agccataact ctttattgag agtagagcta   1260

gggccgcagg gattgctgtg gtcacgttgc ggacaaaaat gaccactcgt tggaagacag   1320

gagaggagtg tttagttaca aaagcagtca acaattcagg tgtatctata ttcagtcagc   1380

aaataaaagt tgttcaactt ggttgctaat gggacccact ctactgaggc tttgtataga   1440

actcatagag gaagatggct tcaagcaatg aactaccctg tgcttttctt aggactaaaa   1500

tctcaggaag ttggtgatga atgaaaacct tagtcccact ggcactgcac gaggggccag   1560

gagagcagca gcatcataag ccacagggtg gggcagccaa ggcaggggca ttctgagctg   1620

ttggggaggg gtggcaggca gggtggggca ctgtgaggtg tcggggaggg cattgtgaag   1680

tgtggggtgg ggcattctgt gccacatgcc tgggctccca cctggggcca gtgggcttca   1740

gtctgtaggt gactacagaa ggaggaggag ctccgtctgt tctctcttca ggcagttgtt   1800

gtgtctctca gcgcttgttg ggttcacaac ctattaaata agccagctgg tcttcaccct   1860

cccagacaag tcaactcagg ggaggcagca gggtgtgggc cttgacccgc agccctagcc   1920

ggggccgggg ccggggccag ggatggtgcc cggggccgcg ctgtgaggtg ggcaggcgag   1980

gagcgggaag accatctctg caagtgcagc atagcctcgg cctaggacag tgggagtgtg   2040

tggccaaagc tgtgagcaga ggcacaggtg gtggcagaca gtagaggcgc cccatgggga   2100

acatactgac ctgttgtgtg caccctagcg tcagcctcga gtttgaccag caacaggggt   2160

cggtgtgtcc ctctgaatct gagatctatg aggcaggagc tggggacagg atggcaggag   2220

cgcccatggc tgctgctgtg cagcctgctg aggtgaccgt tgaagttggt gaggacctcc   2280

acatgcacca cattcgtgac caggagatgc ctgaagcttt ggagtttagc ctttctgcca   2340

atccagaggc aagcacaata ttccagagga actctcaaac agatgctttg gagtttaacc   2400

cttctgccaa tccagaggca agcacaatat tccagaggaa ctctcaaaca gatgttgtag   2460

aaataagaag aagcaactgt acaaaccatg tatctactga gcgtttcagt caacaataca   2520

gctcgtgttc gacaatattc cttgatgaca gcacagccag ccagcattat cttacaatga   2580

caataatatc tgtgaccttg gagatacctc atcatatcac acaaagagat gcagatagat   2640

ctttgagcat acctgatgaa cagttacact catttgcgac agggtttcac catgttggcc   2700

aggatggtct tgaactcctg acctcgtgat ccacccacct tggcctccca aagtgctgtg   2760

attacaggtg tgagccacca tgcctggccc agaaaatgta tctttttaaa aggtaattgt   2820

aagctgtcta taggaccctg caagccacta cccaattttt gaagccattc ctccttctgt   2880

tccacacagg tttccaccgt gcacattacg aagaacagaa atggaggtgg gagtttaaat   2940

aactattcct cctccattcc atcgactccc agcaccagcc aggaggaccc tcagttcagt   3000

gttcctccca ctgccaacac acccaccccc gtttgcaagc ggtccatgcg ctggtccaac   3060

ctgtttacat ctgagaaagg gagtcaccca gacaaagaga ggaaagcccc ggagaatcat   3120

gctgacacca tcgggagcgg cagagccatc cccattaaac agggcatgct cttaaagcga   3180

agtgggaaat ggctgaagac atggaaaaag aaatacgtca ccctgtgttc caatggcgtg   3240

ctcacctatt attcaagctt aggtgattat atgaagaata ttcataaaaa agagattgac   3300

cttcggacat ctaccatcaa agtcccagga aagtggccat ccctagccac atcggcctgt   3360

gcacccatct ccagctctaa aagcaatggc ctatccaagg acatggacac cgggctgggt   3420

gactccatat gcttcagccc cagtatctcc agcaccacca gccccaagct caacccgccc   3480

ccctctcctc atgccaataa aaagaaacac ctaaagaaga aaagcaccaa caactttatg   3540

attgtgtctg ccactggcca aacatggcac tttgaagcca cgacgtatga ggagcgggat   3600

gcctgggtcc aagccatcca gagccagatc ctggccagcc tgcagtcatg cgagagcagt   3660

aaaagcaagt cccagctgac cagccagagc gaggccatgg ccctgcagtc gatccaaaac   3720

atgcgtggga acgcccactg tgtggactat gagacccaga atcctaagtg ggccagtttg   3780

aacttgggag tcctcatgtg tattgaatgc tcaggaatcc accgcagtct tggcacccgc   3840

ctttcccgtg tgcgatctct ggagctggat gactggccag ttgagctcag gaaggttatg   3900

tcatctattg gcaatgacct agccaacagc atctgggaag ggagcagcca ggggcagaca   3960

aaaccctcag taaagtccac gagggaagag aaggaacggt ggatccgttc caaatatgag   4020

gagaagctct ttctggcccc actaccctgc actgagctgt ccctgggcca gcacctgctg   4080

cgggccaccg ctgatgagga cctgcagaca gccatcctgc tgctggcaca tggctcccgt   4140

gaggaggtga acgagacctg tggg                                          4164


<210>  4998
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  4998

Met Gly Asn Ile Leu Thr Cys Cys Val His Pro Ser Val Ser Leu Glu 
1               5                   10                  15      


Phe Asp Gln Gln Gln Gly Ser Val Cys Pro Ser Glu Ser Glu Ile Tyr 
            20                  25                  30          


Glu Ala Gly Ala Gly Asp Arg Met Ala Gly Ala Pro Met Ala Ala Ala 
        35                  40                  45              


Val Gln Pro Ala Glu Val Thr Val Glu Val Gly Glu Asp Leu His Met 
    50                  55                  60                  


His His Ile Arg Asp Gln Glu Met Pro Glu Ala Leu Glu Phe Ser Leu 
65                  70                  75                  80  


Ser Ala Asn Pro Glu Ala Ser Thr Ile Phe Gln Arg Asn Ser Gln Thr 
                85                  90                  95      


Asp Ala Leu Glu Phe Asn Pro Ser Ala Asn Pro Glu Ala Ser Thr Ile 
            100                 105                 110         


Phe Gln Arg Asn Ser Gln Thr Asp Val Val Glu Ile Arg Arg Ser Asn 
        115                 120                 125             


Cys Thr Asn His Val Ser Thr Glu Arg Phe Ser Gln Gln Tyr Ser Ser 
    130                 135                 140                 


Cys Ser Thr Ile Phe Leu Asp Asp Ser Thr Ala Ser Gln His Tyr Leu 
145                 150                 155                 160 


Thr Met Thr Ile Ile Ser Val Thr Leu Glu Ile Pro His His Ile Thr 
                165                 170                 175     


Gln Arg Asp Ala Asp Arg Ser Leu Ser Ile Pro Asp Glu Gln Leu His 
            180                 185                 190         


Ser Phe Ala Thr Gly Phe His His Val Gly Gln Asp Gly Leu Glu Leu 
        195                 200                 205             


Leu Thr Ser 
    210     


<210>  4999
<211>  3852
<212>  DNA
<213>  Homosapiens

<400>  4999
aaataataat aataataata ataatctaca atgtcatttc ccatccaagc ttgacttcta     60

cctttacttt ctgatgtggt tttgccatgt ccccacccaa atctcatcat gaattataat    120

ccccataatc ctgatgtgtt gagggagggg cctaggggga ggtgatcaga tcacgggggc    180

agttatcctc atgctgttct tgtgatattc agtaagtcct catgagatct tatagggttt    240

tgttttgttt tgttttttag gatggagtct tgctctgttg tccaggcagg agtgccatgg    300

cacgatcttg gctcactgca gtctctgcct cttgagttcc agtaattctc ctgcctcagc    360

ctcctgagta gctgggatta caggcatgca ccaccacacc cagctaattt ttgtattttt    420

agtagagaca ggatttcact acattagcta ggctggtctc aaactcctga cctcagttga    480

tccacctgcc ttggcctccc aaagtactag ggttacaagt gtgagccacc atgcccagct    540

gagatctgat ggttttatac atgtttgaca gttgctcctt cacatgttgc cactctctgt    600

gcggccacca tgtaagtcgg acctgccctt ctgccatgat tgtaagtttc ctgaggcctc    660

cccagccatg tgaaactgag tcaattaaac ctcttccctt taaaaattac ccaacctcag    720

gtatttcttt atatcagtgt gaaaacagat tgctatactt tctgataatc atgcttaagc    780

aattggggaa ttcagactac ctgggatcaa accagggccc cacccttagc agtcatgtga    840

ccttggggag gttacttacc ttctccgtct caacaacttc tgtaaaatct gtaacatgag    900

attgtttctg agggttaaat gagcatagca cagtggggac actgtcaggc acacactact    960

tgccagatgt caagtattca tctttattga aataggactg tggtaagcca ctttatggct   1020

ctcgattctg tatgagaaaa tcatgcttag tgccttgtta gtaaaagaaa gaaaatctga   1080

aagtccctgc catggaagga agaaatagcg gggagaaaag ggagttggta agtttcagca   1140

tttcagagct tggagggaca agttaggttt ctattttatg gagaaggagg tggaggcagg   1200

atgggtccta aggtgtcatt caaaacacac agccataact ctttattgag agtagagcta   1260

gggccgcagg gattgctgtg gtcacgttgc ggacaaaaat gaccactcgt tggaagacag   1320

gagaggagtg tttagttaca aaagcagtca acaattcagg tgtatctata ttcagtcagc   1380

aaataaaagt tgttcaactt ggttgctaat gggacccact ctactgaggc tttgtataga   1440

actcatagag gaagatggct tcaagcaatg aactaccctg tgcttttctt aggactaaaa   1500

tctcaggaag ttggtgatga atgaaaacct tagtcccact ggcactgcac gaggggccag   1560

gagagcagca gcatcataag ccacagggtg gggcagccaa ggcaggggca ttctgagctg   1620

ttggggaggg gtggcaggca gggtggggca ctgtgaggtg tcggggaggg cattgtgaag   1680

tgtggggtgg ggcattctgt gccacatgcc tgggctccca cctggggcca gtgggcttca   1740

gtctgtaggt gactacagaa ggaggaggag ctccgtctgt tctctcttca ggcagttgtt   1800

gtgtctctca gcgcttgttg ggttcacaac ctattaaata agccagctgg tcttcaccct   1860

cccagacaag tcaactcagg ggaggcagca gggtgtgggc cttgacccgc agccctagcc   1920

ggggccgggg ccggggccag ggatggtgcc cggggccgcg ctgtgaggtg ggcaggcgag   1980

gagcgggaag accatctctg caagtgcagc atagcctcgg cctaggacag tgggagtgtg   2040

tggccaaagc tgtgagcaga ggcacaggtg gtggcagaca gtagaggcgc cccatgggga   2100

acatactgac ctgttgtgtg caccctagcg tcagcctcga gtttgaccag caacaggggt   2160

cggtgtgtcc ctctgaatct gagatctatg aggcaggagc tggggacagg atggcaggag   2220

cgcccatggc tgctgctgtg cagcctgctg aggtgaccgt tgaagttggt gaggacctcc   2280

acatgcacca cattcgtgac caggagatgc ctgaagcttt ggagtttagc ctttctgcca   2340

atccagaggc aagcacaata ttccagagga actctcaaac agatgctttg gagtttaacc   2400

cttctgccaa tccagaggca agcacaatat tccagaggaa ctctcaaaca gatgttgtag   2460

aaataagaag aagcaactgt acaaaccatt gtgaccttgg agatacctca tcatatcaca   2520

caaagagatg cagatagatc tttgagcata cctgatgaac agttacactc atttgcggtt   2580

tccaccgtgc acattacgaa gaacagaaat ggaggtggga gtttaaataa ctattcctcc   2640

tccattccat cgactcccag caccagccag gaggaccctc agttcagtgt tcctcccact   2700

gccaacacac ccacccccgt ttgcaagcgg tccatgcgct ggtccaacct gtttacatct   2760

gagaaaggga gtcacccaga caaagagagg aaagccccgg agaatcatgc tgacaccatc   2820

gggagcggca gagccatccc cattaaacag ggcatgctct taaagcgaag tgggaaatgg   2880

ctgaagacat ggaaaaagaa atacgtcacc ctgtgttcca atggcgtgct cacctattat   2940

tcaagcttag gtgattatat gaagaatatt cataaaaaag agattgacct tcggacatct   3000

accatcaaag tcccaggaaa gtggccatcc ctagccacat cggcctgtgc acccatctcc   3060

agctctaaaa gcaatggcct atccaaggac atggacaccg ggctgggtga ctccatatgc   3120

ttcagcccca gtatctccag caccaccagc cccaagctca acccgccccc ctctcctcat   3180

gccaataaaa agaaacacct aaagaagaaa agcaccaaca actttatgat tgtgtctgcc   3240

actggccaaa catggcactt tgaagccacg acgtatgagg agcgggatgc ctgggtccaa   3300

gccatccaga gccagatcct ggccagcctg cagtcatgcg agagcagtaa aagcaagtcc   3360

cagctgacca gccagagcga ggccatggcc ctgcagtcga tccaaaacat gcgtgggaac   3420

gcccactgtg tggactatga gacccagaat cctaagtggg ccagtttgaa cttgggagtc   3480

ctcatgtgta ttgaatgctc aggaatccac cgcagtcttg gcacccgcct ttcccgtgtg   3540

cgatctctgg agctggatga ctggccagtt gagctcagga aggttatgtc atctattggc   3600

aatgacctag ccaacagcat ctgggaaggg agcagccagg ggcagacaaa accctcagta   3660

aagtccacga gggaagagaa ggaacggtgg atccgttcca aatatgagga gaagctcttt   3720

ctggccccac taccctgcac tgagctgtcc ctgggccagc acctgctgcg ggccaccgct   3780

gatgaggacc tgcagacagc catcctgctg ctggcacatg gctcccgtga ggaggtgaac   3840

gagacctgtg gg                                                       3852


<210>  5000
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  5000

Met Gly Asn Ile Leu Thr Cys Cys Val His Pro Ser Val Ser Leu Glu 
1               5                   10                  15      


Phe Asp Gln Gln Gln Gly Ser Val Cys Pro Ser Glu Ser Glu Ile Tyr 
            20                  25                  30          


Glu Ala Gly Ala Gly Asp Arg Met Ala Gly Ala Pro Met Ala Ala Ala 
        35                  40                  45              


Val Gln Pro Ala Glu Val Thr Val Glu Val Gly Glu Asp Leu His Met 
    50                  55                  60                  


His His Ile Arg Asp Gln Glu Met Pro Glu Ala Leu Glu Phe Ser Leu 
65                  70                  75                  80  


Ser Ala Asn Pro Glu Ala Ser Thr Ile Phe Gln Arg Asn Ser Gln Thr 
                85                  90                  95      


Asp Ala Leu Glu Phe Asn Pro Ser Ala Asn Pro Glu Ala Ser Thr Ile 
            100                 105                 110         


Phe Gln Arg Asn Ser Gln Thr Asp Val Val Glu Ile Arg Arg Ser Asn 
        115                 120                 125             


Cys Thr Asn His Cys Asp Leu Gly Asp Thr Ser Ser Tyr His Thr Lys 
    130                 135                 140                 


Arg Cys Arg 
145         


<210>  5001
<211>  4420
<212>  DNA
<213>  Homosapiens

<400>  5001
aaataataat aataataata ataatctaca atgtcatttc ccatccaagc ttgacttcta     60

cctttacttt ctgatgtggt tttgccatgt ccccacccaa atctcatcat gaattataat    120

ccccataatc ctgatgtgtt gagggagggg cctaggggga ggtgatcaga tcacgggggc    180

agttatcctc atgctgttct tgtgatattc agtaagtcct catgagatct tatagggttt    240

tgttttgttt tgttttttag gatggagtct tgctctgttg tccaggcagg agtgccatgg    300

cacgatcttg gctcactgca gtctctgcct cttgagttcc agtaattctc ctgcctcagc    360

ctcctgagta gctgggatta caggcatgca ccaccacacc cagctaattt ttgtattttt    420

agtagagaca ggatttcact acattagcta ggctggtctc aaactcctga cctcagttga    480

tccacctgcc ttggcctccc aaagtactag ggttacaagt gtgagccacc atgcccagct    540

gagatctgat ggttttatac atgtttgaca gttgctcctt cacatgttgc cactctctgt    600

gcggccacca tgtaagtcgg acctgccctt ctgccatgat tgtaagtttc ctgaggcctc    660

cccagccatg tgaaactgag tcaattaaac ctcttccctt taaaaattac ccaacctcag    720

gtatttcttt atatcagtgt gaaaacagat tgctatactt tctgataatc atgcttaagc    780

aattggggaa ttcagactac ctgggatcaa accagggccc cacccttagc agtcatgtga    840

ccttggggag gttacttacc ttctccgtct caacaacttc tgtaaaatct gtaacatgag    900

attgtttctg agggttaaat gagcatagca cagtggggac actgtcaggc acacactact    960

tgccagatgt caagtattca tctttattga aataggactg tggtaagcca ctttatggct   1020

ctcgattctg tatgagaaaa tcatgcttag tgccttgtta gtaaaagaaa gaaaatctga   1080

aagtccctgc catggaagga agaaatagcg gggagaaaag ggagttggta agtttcagca   1140

tttcagagct tggagggaca agttaggttt ctattttatg gagaaggagg tggaggcagg   1200

atgggtccta aggtgtcatt caaaacacac agccataact ctttattgag agtagagcta   1260

gggccgcagg gattgctgtg gtcacgttgc ggacaaaaat gaccactcgt tggaagacag   1320

gagaggagtg tttagttaca aaagcagtca acaattcagg tgtatctata ttcagtcagc   1380

aaataaaagt tgttcaactt ggttgctaat gggacccact ctactgaggc tttgtataga   1440

actcatagag gaagatggct tcaagcaatg aactaccctg tgcttttctt aggactaaaa   1500

tctcaggaag ttggtgatga atgaaaacct tagtcccact ggcactgcac gaggggccag   1560

gagagcagca gcatcataag ccacagggtg gggcagccaa ggcaggggca ttctgagctg   1620

ttggggaggg gtggcaggca gggtggggca ctgtgaggtg tcggggaggg cattgtgaag   1680

tgtggggtgg ggcattctgt gccacatgcc tgggctccca cctggggcca gtgggcttca   1740

gtctgtaggt gactacagaa ggaggaggag ctccgtctgt tctctcttca ggcagttgtt   1800

gtgtctctca gcgcttgttg ggttcacaac ctattaaata agccagctgg tcttcaccct   1860

cccagacaag tcaactcagg ggaggcagca gggtgtgggc cttgacccgc agccctagcc   1920

ggggccgggg ccggggccag ggatggtgcc cggggccgcg ctgtgaggtg ggcaggcgag   1980

gagcgggaag accatctctg caagtgcagc atagcctcgg cctaggacag tgggagtgtg   2040

tggccaaagc tgtgagcaga ggcacaggtg gtggcagaca gtagaggcgc cccatgggga   2100

acatactgac ctgttgtgtg caccctagcg tcagcctcga gtttgaccag caacaggggt   2160

cggtgtgtcc ctctgaatct gagatctatg aggcaggagc tggggacagg atggcaggag   2220

cgcccatggc tgctgctgtg cagcctgctg aggtgaccgt tgaagttggt gaggacctcc   2280

acatgcacca cattcgtgac caggagatgc ctgaagcttt ggagtttagc ctttctgcca   2340

atccagaggc aagcacaata ttccagagga actctcaaac agatgctttg gagtttaacc   2400

cttctgccaa tccagaggca agcacaatat tccagaggaa ctctcaaaca gatgttgtag   2460

aaataagaag aagcaactgt acaaaccatg tatctactga gcgtttcagt caacaataca   2520

gctcgtgttc gacaatattc cttgatgaca gcacagccag ccagcattat cttacaatga   2580

caataatatc tgtgaccttg gagatacctc atcatatcac acaaagagat gcagatagat   2640

ctttgagcat acctgatgaa cagttacact catttgcggt ttccaccgtg cacattacga   2700

agaacagaaa tggaggtggg agtttaaata actattcctc ctccattcca tcgactccca   2760

gcaccagcca ggaggaccct cagttcagtg ttcctcccac tgccaacaca cccacccccg   2820

tttgcaagcg gtccatgcgc tggtccaacc tgtttacatc tgagaaaggg agtcacccag   2880

acaaagagag gaaagccccg gagaatcatg ctgacaccat cgggagcggc agagccatcc   2940

ccattaaaca gggcatgctc ttaaagcgaa gtgggaaatg gctgaagaca tggaaaaaga   3000

aatacgtcac cctgtgttcc aatggcgtgc tcacctatta ttcaagctta ggtgattata   3060

tgaagaatat tcataaaaaa gagattgacc ttcggacatc taccatcaaa gtcccaggaa   3120

agtggccatc cctagccaca tcggcctgtg cacccatctc cagctctaaa agcaatggcc   3180

tatccaagga catggacacc gggctgggtg actccatatg cttcagcccc agtatctcca   3240

gcaccaccag ccccaagctc aacccgcccc cctctcctca tgccaataaa aagaaacacc   3300

taaagaagaa aagcaccaac aactttatga ttgtgtctgc cactggccaa acatggcact   3360

ttgaagccac gacgtatgag gagcgggatg cctgggtcca agccatccag agccagatcc   3420

tggccagcct gcagtcatgc gagagcagta aaagcaagtc ccagctgacc agccagagcg   3480

aggccatggc cctgcagtcg atccaaaaca tgcgtgggaa cgcccactgt gtggactatg   3540

agacccagaa tcctaagtgg gccagtttga acttgggagt cctcatgtgt attgaatgct   3600

caggaatcca ccgcagtctt ggcacccgcc tttcccgtgt gcgatctctg gagctggatg   3660

actggccagt tgagctcagg aaggttatgt catctattgg caatgaccta gccaacagca   3720

tctgggaagg gagcagccag gggcagacaa aaccctcaaa gctctttctg gccccactac   3780

cctgcactga gctgtccctg ggccagcacc tgctgcgggc caccgctgat gaggacctgc   3840

agacagccat cctgctgctg gcacatggct cccgtgagga ggtgaacgag acctgtgggg   3900

agggagacgg ctgcacggcg ctccatctgg cctgccgcaa ggggaatgtg gtcctggcac   3960

agctcctgat ctggtacggg gtggacgtca tggcccgaga tgcccacggg aacacagcgc   4020

tgacctacgc ccggcaggcc tccagccagg agtgcatcaa cgtgcttctg cagtacggct   4080

gccccgacga gtgcgtgtag tatctgtttt atttgactgc agtctccttg gtgcaaaaac   4140

aaaatgggaa aaataaggat aactcagaat ttcaaaagga aatcacaaat tcagctagta   4200

atagcatttt cagtactttt cataaactaa gtaaatacac aaaatgttga tttttctgac   4260

cataagacat attttatgtc cttttgccaa ggtggatgtg ttagtctcag gccctcctgg   4320

ccacattgcc caagtcacac aggcttctgt attatgtatt tagataaaat gtgtgaaaat   4380

atatttgaaa aaaaagttca taaatatgca ttgatttttg                         4420


<210>  5002
<211>  668
<212>  PRT
<213>  Homosapiens

<400>  5002

Met Gly Asn Ile Leu Thr Cys Cys Val His Pro Ser Val Ser Leu Glu 
1               5                   10                  15      


Phe Asp Gln Gln Gln Gly Ser Val Cys Pro Ser Glu Ser Glu Ile Tyr 
            20                  25                  30          


Glu Ala Gly Ala Gly Asp Arg Met Ala Gly Ala Pro Met Ala Ala Ala 
        35                  40                  45              


Val Gln Pro Ala Glu Val Thr Val Glu Val Gly Glu Asp Leu His Met 
    50                  55                  60                  


His His Ile Arg Asp Gln Glu Met Pro Glu Ala Leu Glu Phe Ser Leu 
65                  70                  75                  80  


Ser Ala Asn Pro Glu Ala Ser Thr Ile Phe Gln Arg Asn Ser Gln Thr 
                85                  90                  95      


Asp Ala Leu Glu Phe Asn Pro Ser Ala Asn Pro Glu Ala Ser Thr Ile 
            100                 105                 110         


Phe Gln Arg Asn Ser Gln Thr Asp Val Val Glu Ile Arg Arg Ser Asn 
        115                 120                 125             


Cys Thr Asn His Val Ser Thr Glu Arg Phe Ser Gln Gln Tyr Ser Ser 
    130                 135                 140                 


Cys Ser Thr Ile Phe Leu Asp Asp Ser Thr Ala Ser Gln His Tyr Leu 
145                 150                 155                 160 


Thr Met Thr Ile Ile Ser Val Thr Leu Glu Ile Pro His His Ile Thr 
                165                 170                 175     


Gln Arg Asp Ala Asp Arg Ser Leu Ser Ile Pro Asp Glu Gln Leu His 
            180                 185                 190         


Ser Phe Ala Val Ser Thr Val His Ile Thr Lys Asn Arg Asn Gly Gly 
        195                 200                 205             


Gly Ser Leu Asn Asn Tyr Ser Ser Ser Ile Pro Ser Thr Pro Ser Thr 
    210                 215                 220                 


Ser Gln Glu Asp Pro Gln Phe Ser Val Pro Pro Thr Ala Asn Thr Pro 
225                 230                 235                 240 


Thr Pro Val Cys Lys Arg Ser Met Arg Trp Ser Asn Leu Phe Thr Ser 
                245                 250                 255     


Glu Lys Gly Ser His Pro Asp Lys Glu Arg Lys Ala Pro Glu Asn His 
            260                 265                 270         


Ala Asp Thr Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Met 
        275                 280                 285             


Leu Leu Lys Arg Ser Gly Lys Trp Leu Lys Thr Trp Lys Lys Lys Tyr 
    290                 295                 300                 


Val Thr Leu Cys Ser Asn Gly Val Leu Thr Tyr Tyr Ser Ser Leu Gly 
305                 310                 315                 320 


Asp Tyr Met Lys Asn Ile His Lys Lys Glu Ile Asp Leu Arg Thr Ser 
                325                 330                 335     


Thr Ile Lys Val Pro Gly Lys Trp Pro Ser Leu Ala Thr Ser Ala Cys 
            340                 345                 350         


Ala Pro Ile Ser Ser Ser Lys Ser Asn Gly Leu Ser Lys Asp Met Asp 
        355                 360                 365             


Thr Gly Leu Gly Asp Ser Ile Cys Phe Ser Pro Ser Ile Ser Ser Thr 
    370                 375                 380                 


Thr Ser Pro Lys Leu Asn Pro Pro Pro Ser Pro His Ala Asn Lys Lys 
385                 390                 395                 400 


Lys His Leu Lys Lys Lys Ser Thr Asn Asn Phe Met Ile Val Ser Ala 
                405                 410                 415     


Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr Glu Glu Arg Asp 
            420                 425                 430         


Ala Trp Val Gln Ala Ile Gln Ser Gln Ile Leu Ala Ser Leu Gln Ser 
        435                 440                 445             


Cys Glu Ser Ser Lys Ser Lys Ser Gln Leu Thr Ser Gln Ser Glu Ala 
    450                 455                 460                 


Met Ala Leu Gln Ser Ile Gln Asn Met Arg Gly Asn Ala His Cys Val 
465                 470                 475                 480 


Asp Tyr Glu Thr Gln Asn Pro Lys Trp Ala Ser Leu Asn Leu Gly Val 
                485                 490                 495     


Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Ser Leu Gly Thr Arg 
            500                 505                 510         


Leu Ser Arg Val Arg Ser Leu Glu Leu Asp Asp Trp Pro Val Glu Leu 
        515                 520                 525             


Arg Lys Val Met Ser Ser Ile Gly Asn Asp Leu Ala Asn Ser Ile Trp 
    530                 535                 540                 


Glu Gly Ser Ser Gln Gly Gln Thr Lys Pro Ser Lys Leu Phe Leu Ala 
545                 550                 555                 560 


Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly Gln His Leu Leu Arg Ala 
                565                 570                 575     


Thr Ala Asp Glu Asp Leu Gln Thr Ala Ile Leu Leu Leu Ala His Gly 
            580                 585                 590         


Ser Arg Glu Glu Val Asn Glu Thr Cys Gly Glu Gly Asp Gly Cys Thr 
        595                 600                 605             


Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu 
    610                 615                 620                 


Leu Ile Trp Tyr Gly Val Asp Val Met Ala Arg Asp Ala His Gly Asn 
625                 630                 635                 640 


Thr Ala Leu Thr Tyr Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asn 
                645                 650                 655     


Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu Cys Val 
            660                 665             


<210>  5003
<211>  3355
<212>  DNA
<213>  Homosapiens

<400>  5003
gagtctcact ctgtcaccca ggctggagtt ctgtggcaca gtcttggctc actgcaacct     60

ccgcctgccg gagacgaggt ttcactatgt aggcaaagct ggtctcgaac tcctgacctc    120

agatgatcca cccgcctcag cctcccaaag tgctgggatt acaggcgtga gccaccgcac    180

ctggcctgtt tattctctta agagagaaaa tgaggggatt aatggactgt agttctggac    240

aaggtggaaa actcttaaag tggaagtatt ggggcaagtg ctctgacagg ctaggatggt    300

gcagtcagtc ccttcaccca gaaatcagta gaatgttaac agttcagact caaaccttgt    360

gaaaaacagg tggtggaaag gaaatccctc acagcaactg gcaccataat caagacagaa    420

tgtttgcaga ataaatggag ttacctgctt tcagccccag gttgtagcta ttgtctgccc    480

tgatgatatg tgataataat ttgtgatcct attgtcttaa aatggggtca ctcatctcca    540

gtagaattaa gtccacagtg aagttgtccc cccatcccca aagagataaa catatatgaa    600

tgaactcaca tgataacaac tactgctgcc tgggatcatg agagacctga actgaactga    660

taggaagtga aaggtggctg agataatgag aatagaccca tctgcagagg atcataaaac    720

cagcaaagac aagatcttgt ctaagatgcc ttcacaaact ttgtccatga gaactctaag    780

gacttctcca gacctgttgg ctgctgctgt gatctctgcc caagaggagc ctctgaccaa    840

catccaaagg gcttctggac ccactggact cctctggagt tgctccttca catgttgcca    900

ctctctgtgc ggccaccatg taagtcggac ctgcccttct gccatgattg actaaaatct    960

caggaagttg gtgatgaatg aaaaccttag tcccactggc actgcacgag gggccaggag   1020

agcagcagca tcataagcca caggcgtcag cctcgagttt gaccagcaac aggggtcggt   1080

gtgtccctct gaatctgaga tctatgaggc aggagctggg gacaggatgg caggagcgcc   1140

catggctgct gctgtgcagc ctgctgaggt gaccgttgaa gttggtgagg acctccacat   1200

gcaccacatt cgtgaccagg agatgcctga agctttggag tttagccttt ctgccaatcc   1260

agaggcaagc acaatattcc agaggaactc tcaaacagat gctttggagt ttaacccttc   1320

tgccaatcca gaggcaagca caatattcca gaggaactct caaacagatg gtatctactg   1380

agcgtttcag tcaacaatac agctcgtgtt cgacaatatt ccttgatgac agcacagcca   1440

gccagcatta tcttacaatg acaataatat ctgtgacctt ggagatacct catcatatca   1500

cacaaagaga tgcagataga tctttgagca tacctgatga acagttacac tcatttgcgg   1560

tttccaccgt gcacattacg aagaacagaa atggaggtgg gagtttaaat aactattcct   1620

cctccattcc atcgactccc agcaccagcc aggaggaccc tcagttcagt gttcctccca   1680

ctgccaacac acccaccccc gtttgcaagc ggtccatgcg ctggtccaac ctgtttacat   1740

ctgagaaagg gagtcaccca gacaaagaga ggaaagcccc ggagaatcat gctgacacca   1800

tcgggagcgg cagagccatc cccattaaac agggcatgct cttaaagcga agtgggaaat   1860

ggctgaagac atggaaaaag aaatacgtca ccctgtgttc caatggcgtg ctcacctatt   1920

attcaagctt aggtgattat atgaagaata ttcataaaaa agagattgac cttcggacat   1980

ctaccatcaa agtcccagga aagtggccat ccctagccac atcggcctgt gcacccatct   2040

ccagctctaa aagcaatggc ctatccaagg acatggacac cgggctgggt gactccatat   2100

gcttcagccc cagtatctcc agcaccacca gccccaagct caacccgccc ccctctcctc   2160

atgccaataa aaagaaacac ctaaagaaga aaagcaccaa caactttatg attgtgtctg   2220

ccactggcca aacatggcac tttgaagcca cgacgtatga ggagcgggat gcctgggtcc   2280

aagccatcca gagccagatc ctggccagcc tgcagtcatg cgagagcagt aaaagcaagt   2340

cccagctgac cagccagagc gaggccatgg ccctgcagtc gatccaaaac atgcgtggga   2400

acgcccactg tgtggactat gagacccaga atcctaagtg ggccagtttg aacttgggag   2460

tcctcatgtg tattgaatgc tcaggaatcc accgcagtct tggcacccgc ctttcccgtg   2520

tgcgatctct ggagctggat gactggccag ttgagctcag gaaggttatg tcatctattg   2580

gcaatgacct agccaacagc atctgggaag ggagcagcca ggggcagaca aaaccctcag   2640

taaagtccac gagggaagag aaggaacggt ggatccgttc caaatatgag gagaagctct   2700

ttctggcccc actaccctgc actgagctgt ccctgggcca gcacctgctg cgggccaccg   2760

ctgatgagga cctgcagaca gccatcctgc tgctggcaca tggctcccgt gaggaggtga   2820

acgagacctg tggggaggga gacggctgca cggcgctcca tctggcctgc cgcaagggga   2880

atgtggtcct ggcacagctc ctgatctggt acggggtgga cgtcatggcc cgagatgccc   2940

acgggaacac agcgctgacc tacgcccggc aggcctccag ccaggagtgc atcaacgtgc   3000

ttctgcagta cggctgcccc gacgagtgcg tgtagtatct gttttatttg actgcagtct   3060

ccttggtgca aaaacaaaat gggaaaaata aggataactc agaatttcaa aaggaaatca   3120

caaattcagc tagtaatagc attttcagta cttttcataa actaagtaaa tacacaaaat   3180

gttgattttt ctgaccataa gacatatttt atgtcctttt gccaaggtgg atgtgttagt   3240

ctcaggccct cctggccaca ttgcccaagt cacacaggct tctgtattat gtatttagat   3300

aaaatgtgtg aaaatatatt tgaaaaaaaa gttcataaat atgcattgat ttttg        3355


<210>  5004
<211>  578
<212>  PRT
<213>  Homosapiens

<400>  5004

Met Leu Trp Ser Leu Thr Leu Leu Pro Ile Gln Arg Gln Ala Gln Tyr 
1               5                   10                  15      


Ser Arg Gly Thr Leu Lys Gln Met Val Ser Thr Glu Arg Phe Ser Gln 
            20                  25                  30          


Gln Tyr Ser Ser Cys Ser Thr Ile Phe Leu Asp Asp Ser Thr Ala Ser 
        35                  40                  45              


Gln His Tyr Leu Thr Met Thr Ile Ile Ser Val Thr Leu Glu Ile Pro 
    50                  55                  60                  


His His Ile Thr Gln Arg Asp Ala Asp Arg Ser Leu Ser Ile Pro Asp 
65                  70                  75                  80  


Glu Gln Leu His Ser Phe Ala Val Ser Thr Val His Ile Thr Lys Asn 
                85                  90                  95      


Arg Asn Gly Gly Gly Ser Leu Asn Asn Tyr Ser Ser Ser Ile Pro Ser 
            100                 105                 110         


Thr Pro Ser Thr Ser Gln Glu Asp Pro Gln Phe Ser Val Pro Pro Thr 
        115                 120                 125             


Ala Asn Thr Pro Thr Pro Val Cys Lys Arg Ser Met Arg Trp Ser Asn 
    130                 135                 140                 


Leu Phe Thr Ser Glu Lys Gly Ser His Pro Asp Lys Glu Arg Lys Ala 
145                 150                 155                 160 


Pro Glu Asn His Ala Asp Thr Ile Gly Ser Gly Arg Ala Ile Pro Ile 
                165                 170                 175     


Lys Gln Gly Met Leu Leu Lys Arg Ser Gly Lys Trp Leu Lys Thr Trp 
            180                 185                 190         


Lys Lys Lys Tyr Val Thr Leu Cys Ser Asn Gly Val Leu Thr Tyr Tyr 
        195                 200                 205             


Ser Ser Leu Gly Asp Tyr Met Lys Asn Ile His Lys Lys Glu Ile Asp 
    210                 215                 220                 


Leu Arg Thr Ser Thr Ile Lys Val Pro Gly Lys Trp Pro Ser Leu Ala 
225                 230                 235                 240 


Thr Ser Ala Cys Ala Pro Ile Ser Ser Ser Lys Ser Asn Gly Leu Ser 
                245                 250                 255     


Lys Asp Met Asp Thr Gly Leu Gly Asp Ser Ile Cys Phe Ser Pro Ser 
            260                 265                 270         


Ile Ser Ser Thr Thr Ser Pro Lys Leu Asn Pro Pro Pro Ser Pro His 
        275                 280                 285             


Ala Asn Lys Lys Lys His Leu Lys Lys Lys Ser Thr Asn Asn Phe Met 
    290                 295                 300                 


Ile Val Ser Ala Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr 
305                 310                 315                 320 


Glu Glu Arg Asp Ala Trp Val Gln Ala Ile Gln Ser Gln Ile Leu Ala 
                325                 330                 335     


Ser Leu Gln Ser Cys Glu Ser Ser Lys Ser Lys Ser Gln Leu Thr Ser 
            340                 345                 350         


Gln Ser Glu Ala Met Ala Leu Gln Ser Ile Gln Asn Met Arg Gly Asn 
        355                 360                 365             


Ala His Cys Val Asp Tyr Glu Thr Gln Asn Pro Lys Trp Ala Ser Leu 
    370                 375                 380                 


Asn Leu Gly Val Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Ser 
385                 390                 395                 400 


Leu Gly Thr Arg Leu Ser Arg Val Arg Ser Leu Glu Leu Asp Asp Trp 
                405                 410                 415     


Pro Val Glu Leu Arg Lys Val Met Ser Ser Ile Gly Asn Asp Leu Ala 
            420                 425                 430         


Asn Ser Ile Trp Glu Gly Ser Ser Gln Gly Gln Thr Lys Pro Ser Val 
        435                 440                 445             


Lys Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile Arg Ser Lys Tyr Glu 
    450                 455                 460                 


Glu Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly 
465                 470                 475                 480 


Gln His Leu Leu Arg Ala Thr Ala Asp Glu Asp Leu Gln Thr Ala Ile 
                485                 490                 495     


Leu Leu Leu Ala His Gly Ser Arg Glu Glu Val Asn Glu Thr Cys Gly 
            500                 505                 510         


Glu Gly Asp Gly Cys Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn 
        515                 520                 525             


Val Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Met Ala 
    530                 535                 540                 


Arg Asp Ala His Gly Asn Thr Ala Leu Thr Tyr Ala Arg Gln Ala Ser 
545                 550                 555                 560 


Ser Gln Glu Cys Ile Asn Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu 
                565                 570                 575     


Cys Val 
        


<210>  5005
<211>  4405
<212>  DNA
<213>  Homosapiens

<400>  5005
aaataataat aataataata ataatctaca atgtcatttc ccatccaagc ttgacttcta     60

cctttacttt ctgatgtggt tttgccatgt ccccacccaa atctcatcat gaattataat    120

ccccataatc ctgatgtgtt gagggagggg cctaggggga ggtgatcaga tcacgggggc    180

agttatcctc atgctgttct tgtgatattc agtaagtcct catgagatct tatagggttt    240

tgttttgttt tgttttttag gatggagtct tgctctgttg tccaggcagg agtgccatgg    300

cacgatcttg gctcactgca gtctctgcct cttgagttcc agtaattctc ctgcctcagc    360

ctcctgagta gctgggatta caggcatgca ccaccacacc cagctaattt ttgtattttt    420

agtagagaca ggatttcact acattagcta ggctggtctc aaactcctga cctcagttga    480

tccacctgcc ttggcctccc aaagtactag ggttacaagt gtgagccacc atgcccagct    540

gagatctgat ggttttatac atgtttgaca gttgctcctt cacatgttgc cactctctgt    600

gcggccacca tgtaagtcgg acctgccctt ctgccatgat tgtaagtttc ctgaggcctc    660

cccagccatg tgaaactgag tcaattaaac ctcttccctt taaaaattac ccaacctcag    720

gtatttcttt atatcagtgt gaaaacagat tgctatactt tctgataatc atgcttaagc    780

aattggggaa ttcagactac ctgggatcaa accagggccc cacccttagc agtcatgtga    840

ccttggggag gttacttacc ttctccgtct caacaacttc tgtaaaatct gtaacatgag    900

attgtttctg agggttaaat gagcatagca cagtggggac actgtcaggc acacactact    960

tgccagatgt caagtattca tctttattga aataggactg tggtaagcca ctttatggct   1020

ctcgattctg tatgagaaaa tcatgcttag tgccttgtta gtaaaagaaa gaaaatctga   1080

aagtccctgc catggaagga agaaatagcg gggagaaaag ggagttggta agtttcagca   1140

tttcagagct tggagggaca agttaggttt ctattttatg gagaaggagg tggaggcagg   1200

atgggtccta aggtgtcatt caaaacacac agccataact ctttattgag agtagagcta   1260

gggccgcagg gattgctgtg gtcacgttgc ggacaaaaat gaccactcgt tggaagacag   1320

gagaggagtg tttagttaca aaagcagtca acaattcagg tgtatctata ttcagtcagc   1380

aaataaaagt tgttcaactt ggttgctaat gggacccact ctactgaggc tttgtataga   1440

actcatagag gaagatggct tcaagcaatg aactaccctg tgcttttctt aggactaaaa   1500

tctcaggaag ttggtgatga atgaaaacct tagtcccact ggcactgcac gaggggccag   1560

gagagcagca gcatcataag ccacagggtg gggcagccaa ggcaggggca ttctgagctg   1620

ttggggaggg gtggcaggca gggtggggca ctgtgaggtg tcggggaggg cattgtgaag   1680

tgtggggtgg ggcattctgt gccacatgcc tgggctccca cctggggcca gtgggcttca   1740

gtctgtaggt gactacagaa ggaggaggag ctccgtctgt tctctcttca ggcagttgtt   1800

gtgtctctca gcgcttgttg ggttcacaac ctattaaata agccagctgg tcttcaccct   1860

cccagacaag tcaactcagg ggaggcagca gggtgtgggc cttgacccgc agccctagcc   1920

ggggccgggg ccggggccag ggatggtgcc cggggccgcg ctgtgaggtg ggcaggcgag   1980

gagcgggaag accatctctg caagtgcagc atagcctcgg cctaggacag tgggagtgtg   2040

tggccaaagc tgtgagcaga ggcacaggtg gtggcagaca gtagaggcgc cccatgggga   2100

acatactgac ctgttgtgtg caccctagcg tcagcctcga gtttgaccag caacaggggt   2160

cggtgtgtcc ctctgaatct gagatctatg aggcaggagc tggggacagg atggcaggag   2220

cgcccatggc tgctgctgtg cagcctgctg aggtgaccgt tgaagttggt gaggacctcc   2280

acatgcacca cattcgtgac caggagatgc ctgaagcttt ggagtttaac ccttctgcca   2340

atccagaggc aagcacaata ttccagagga actctcaaac agatgttgta gaaataagaa   2400

gaagcaactg tacaaaccat gtatctactg agcgtttcag tcaacaatac agctcgtgtt   2460

cgacaatatt ccttgatgac agcacagcca gccagcatta tcttacaatg acaataatat   2520

ctgtgacctt ggagatacct catcatatca cacaaagaga tgcagataga tctttgagca   2580

tacctgatga acagttacac tcatttgcgg tttccaccgt gcacattacg aagaacagaa   2640

atggaggtgg gagtttaaat aactattcct cctccattcc atcgactccc agcaccagcc   2700

aggaggaccc tcagttcagt gttcctccca ctgccaacac acccaccccc gtttgcaagc   2760

ggtccatgcg ctggtccaac ctgtttacat ctgagaaagg gagtcaccca gacaaagaga   2820

ggaaagcccc ggagaatcat gctgacacca tcgggagcgg cagagccatc cccattaaac   2880

agggcatgct cttaaagcga agtgggaaat ggctgaagac atggaaaaag aaatacgtca   2940

ccctgtgttc caatggcgtg ctcacctatt attcaagctt aggtgattat atgaagaata   3000

ttcataaaaa agagattgac cttcggacat ctaccatcaa agtcccagga aagtggccat   3060

ccctagccac atcggcctgt gcacccatct ccagctctaa aagcaatggc ctatccaagg   3120

acatggacac cgggctgggt gactccatat gcttcagccc cagtatctcc agcaccacca   3180

gccccaagct caacccgccc ccctctcctc atgccaataa aaagaaacac ctaaagaaga   3240

aaagcaccaa caactttatg attgtgtctg ccactggcca aacatggcac tttgaagcca   3300

cgacgtatga ggagcgggat gcctgggtcc aagccatcca gagccagatc ctggccagcc   3360

tgcagtcatg cgagagcagt aaaagcaagt cccagctgac cagccagagc gaggccatgg   3420

ccctgcagtc gatccaaaac atgcgtggga acgcccactg tgtggactat gagacccaga   3480

atcctaagtg ggccagtttg aacttgggag tcctcatgtg tattgaatgc tcaggaatcc   3540

accgcagtct tggcacccgc ctttcccgtg tgcgatctct ggagctggat gactggccag   3600

ttgagctcag gaaggttatg tcatctattg gcaatgacct agccaacagc atctgggaag   3660

ggagcagcca ggggcagaca aaaccctcag taaagtccac gagggaagag aaggaacggt   3720

ggatccgttc caaatatgag gagaagctct ttctggcccc actaccctgc actgagctgt   3780

ccctgggcca gcacctgctg cgggccaccg ctgatgagga cctgcagaca gccatcctgc   3840

tgctggcaca tggctcccgt gaggaggtga acgagacctg tggggaggga gacggctgca   3900

cggcgctcca tctggcctgc cgcaagggga atgtggtcct ggcacagctc ctgatctggt   3960

acggggtgga cgtcatggcc cgagatgccc acgggaacac agcgctgacc tacgcccggc   4020

aggcctccag ccaggagtgc atcaacgtgc ttctgcagta cggctgcccc gacgagtgcg   4080

tgtagtatct gttttatttg actgcagtct ccttggtgca aaaacaaaat gggaaaaata   4140

aggataactc agaatttcaa aaggaaatca caaattcagc tagtaatagc attttcagta   4200

cttttcataa actaagtaaa tacacaaaat gttgattttt ctgaccataa gacatatttt   4260

atgtcctttt gccaaggtgg atgtgttagt ctcaggccct cctggccaca ttgcccaagt   4320

cacacaggct tctgtattat gtatttagat aaaatgtgtg aaaatatatt tgaaaaaaaa   4380

gttcataaat atgcattgat ttttg                                         4405


<210>  5006
<211>  663
<212>  PRT
<213>  Homosapiens

<400>  5006

Met Gly Asn Ile Leu Thr Cys Cys Val His Pro Ser Val Ser Leu Glu 
1               5                   10                  15      


Phe Asp Gln Gln Gln Gly Ser Val Cys Pro Ser Glu Ser Glu Ile Tyr 
            20                  25                  30          


Glu Ala Gly Ala Gly Asp Arg Met Ala Gly Ala Pro Met Ala Ala Ala 
        35                  40                  45              


Val Gln Pro Ala Glu Val Thr Val Glu Val Gly Glu Asp Leu His Met 
    50                  55                  60                  


His His Ile Arg Asp Gln Glu Met Pro Glu Ala Leu Glu Phe Asn Pro 
65                  70                  75                  80  


Ser Ala Asn Pro Glu Ala Ser Thr Ile Phe Gln Arg Asn Ser Gln Thr 
                85                  90                  95      


Asp Val Val Glu Ile Arg Arg Ser Asn Cys Thr Asn His Val Ser Thr 
            100                 105                 110         


Glu Arg Phe Ser Gln Gln Tyr Ser Ser Cys Ser Thr Ile Phe Leu Asp 
        115                 120                 125             


Asp Ser Thr Ala Ser Gln His Tyr Leu Thr Met Thr Ile Ile Ser Val 
    130                 135                 140                 


Thr Leu Glu Ile Pro His His Ile Thr Gln Arg Asp Ala Asp Arg Ser 
145                 150                 155                 160 


Leu Ser Ile Pro Asp Glu Gln Leu His Ser Phe Ala Val Ser Thr Val 
                165                 170                 175     


His Ile Thr Lys Asn Arg Asn Gly Gly Gly Ser Leu Asn Asn Tyr Ser 
            180                 185                 190         


Ser Ser Ile Pro Ser Thr Pro Ser Thr Ser Gln Glu Asp Pro Gln Phe 
        195                 200                 205             


Ser Val Pro Pro Thr Ala Asn Thr Pro Thr Pro Val Cys Lys Arg Ser 
    210                 215                 220                 


Met Arg Trp Ser Asn Leu Phe Thr Ser Glu Lys Gly Ser His Pro Asp 
225                 230                 235                 240 


Lys Glu Arg Lys Ala Pro Glu Asn His Ala Asp Thr Ile Gly Ser Gly 
                245                 250                 255     


Arg Ala Ile Pro Ile Lys Gln Gly Met Leu Leu Lys Arg Ser Gly Lys 
            260                 265                 270         


Trp Leu Lys Thr Trp Lys Lys Lys Tyr Val Thr Leu Cys Ser Asn Gly 
        275                 280                 285             


Val Leu Thr Tyr Tyr Ser Ser Leu Gly Asp Tyr Met Lys Asn Ile His 
    290                 295                 300                 


Lys Lys Glu Ile Asp Leu Arg Thr Ser Thr Ile Lys Val Pro Gly Lys 
305                 310                 315                 320 


Trp Pro Ser Leu Ala Thr Ser Ala Cys Ala Pro Ile Ser Ser Ser Lys 
                325                 330                 335     


Ser Asn Gly Leu Ser Lys Asp Met Asp Thr Gly Leu Gly Asp Ser Ile 
            340                 345                 350         


Cys Phe Ser Pro Ser Ile Ser Ser Thr Thr Ser Pro Lys Leu Asn Pro 
        355                 360                 365             


Pro Pro Ser Pro His Ala Asn Lys Lys Lys His Leu Lys Lys Lys Ser 
    370                 375                 380                 


Thr Asn Asn Phe Met Ile Val Ser Ala Thr Gly Gln Thr Trp His Phe 
385                 390                 395                 400 


Glu Ala Thr Thr Tyr Glu Glu Arg Asp Ala Trp Val Gln Ala Ile Gln 
                405                 410                 415     


Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser Lys Ser Lys 
            420                 425                 430         


Ser Gln Leu Thr Ser Gln Ser Glu Ala Met Ala Leu Gln Ser Ile Gln 
        435                 440                 445             


Asn Met Arg Gly Asn Ala His Cys Val Asp Tyr Glu Thr Gln Asn Pro 
    450                 455                 460                 


Lys Trp Ala Ser Leu Asn Leu Gly Val Leu Met Cys Ile Glu Cys Ser 
465                 470                 475                 480 


Gly Ile His Arg Ser Leu Gly Thr Arg Leu Ser Arg Val Arg Ser Leu 
                485                 490                 495     


Glu Leu Asp Asp Trp Pro Val Glu Leu Arg Lys Val Met Ser Ser Ile 
            500                 505                 510         


Gly Asn Asp Leu Ala Asn Ser Ile Trp Glu Gly Ser Ser Gln Gly Gln 
        515                 520                 525             


Thr Lys Pro Ser Val Lys Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile 
    530                 535                 540                 


Arg Ser Lys Tyr Glu Glu Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr 
545                 550                 555                 560 


Glu Leu Ser Leu Gly Gln His Leu Leu Arg Ala Thr Ala Asp Glu Asp 
                565                 570                 575     


Leu Gln Thr Ala Ile Leu Leu Leu Ala His Gly Ser Arg Glu Glu Val 
            580                 585                 590         


Asn Glu Thr Cys Gly Glu Gly Asp Gly Cys Thr Ala Leu His Leu Ala 
        595                 600                 605             


Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly 
    610                 615                 620                 


Val Asp Val Met Ala Arg Asp Ala His Gly Asn Thr Ala Leu Thr Tyr 
625                 630                 635                 640 


Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asn Val Leu Leu Gln Tyr 
                645                 650                 655     


Gly Cys Pro Asp Glu Cys Val 
            660             


<210>  5007
<211>  1704
<212>  DNA
<213>  Homosapiens

<400>  5007
agcaagttcg gtgccgcggg ctggggtagg cggcagtggg gtccctggct ttggggcact     60

gggaagatcg cgagtgggaa ggtcctcccg cggtcctccg ggtcatcttt cctcctgagg    120

agcagcatat ttcgcatctg ccggaggtat tagaattact tgttattggt aaatagccac    180

tatggagact aaggaccaga agaaacaaag aaagaaaaat agtggaccca aagctgcaaa    240

gaaaaagaag cggcatctgc aggatctcca gctaggagac gaagaagatg cctggaagag    300

aaatcccaaa gcttttgcat ttcagtctgc tgtgtggatg gctcgatcct ttcacaggac    360

tcaggatttg aagacaaaaa agcatcatat tccagtggtt gatcgaactc cactagagcc    420

cccaccaata gtggtagtgg tgatggggcc tccaaagttg gaaagagcac tttgatacaa    480

tgcctcattc ggaacttcac ccggcagaag ttgaccgaga tcagaggccc tgtgatgatc    540

gtgtcaggta aaaagctccg actcaccatt attgaatgtg ggtgtgacat taacatgatg    600

attgatctgg ctgaagtagc agatctggta ctgatgctta tagatgccag ctttgggttt    660

gaaatggaaa cgtttgagtt tctaaacatc tgtcaagtac atggctttcc taaaattatg    720

ggagttctca cccacctcga cttcttcaaa cacaataagc aactgaagaa gacaaagaag    780

cgattaaaac acaggttctg gacagaagtt tacctggttg ccaagctgtt ctgcctttct    840

ggaatggtgc atggagaata tcaaaaccaa gaaatgcaca atctgggcca ttttattaca    900

gttatgaagt ttaggcctct cacatggcag acttctcatc cttatatcct ggcagacagg    960

gtggaagatt tgacaaaccc agaggatatc caaacaaaca tcagatgtga ccagcagatg   1020

ttactttacg gttatttaag aggagcgcac ttgaaaaata aaagccaaat tcacatgcca   1080

ggacgaggtg gggcccaccc atgagctggt ccagagtctc atctccaccc actccaccat   1140

tgatgccaag atggcttcaa gtcgagtgat gttgttttct gattccaagc cacttgggtc   1200

agaggctata gataatcaag gggacgagtt ctcactatgt tgcccaggct ggcctcgaac   1260

tcctgggctc aagcaatcct cctgcgttgg cctcccaaag tcctgggatt acaggtgtaa   1320

gccactacgg ctggcctatt attgctgtat tctaacttat tcatctccta tgctaggcta   1380

gcctccaagc tggaagctga attgacagtt gaaaaataat gacatgtata caaggtatgt   1440

ttgaaggatt gcagatgcag gggcaccata tgctaaagga gtgttggaag ctcactgcag   1500

aagatgacaa aagcagactg atatgtatta tttgctgaaa tataagctgg aggcacaggt   1560

gaagattgcc aaacctaatg aacagtttgg caaataagac aggctgtcag gccatggcag   1620

ttcagcagtg ggcgtgctgc ctgtgaacca agtcatttgt tccagaggac tacacttaaa   1680

taccacaaat aaaatcttcc ttgt                                          1704


<210>  5008
<211>  189
<212>  PRT
<213>  Homosapiens

<400>  5008

Met Ile Val Ser Gly Lys Lys Leu Arg Leu Thr Ile Ile Glu Cys Gly 
1               5                   10                  15      


Cys Asp Ile Asn Met Met Ile Asp Leu Ala Glu Val Ala Asp Leu Val 
            20                  25                  30          


Leu Met Leu Ile Asp Ala Ser Phe Gly Phe Glu Met Glu Thr Phe Glu 
        35                  40                  45              


Phe Leu Asn Ile Cys Gln Val His Gly Phe Pro Lys Ile Met Gly Val 
    50                  55                  60                  


Leu Thr His Leu Asp Phe Phe Lys His Asn Lys Gln Leu Lys Lys Thr 
65                  70                  75                  80  


Lys Lys Arg Leu Lys His Arg Phe Trp Thr Glu Val Tyr Leu Val Ala 
                85                  90                  95      


Lys Leu Phe Cys Leu Ser Gly Met Val His Gly Glu Tyr Gln Asn Gln 
            100                 105                 110         


Glu Met His Asn Leu Gly His Phe Ile Thr Val Met Lys Phe Arg Pro 
        115                 120                 125             


Leu Thr Trp Gln Thr Ser His Pro Tyr Ile Leu Ala Asp Arg Val Glu 
    130                 135                 140                 


Asp Leu Thr Asn Pro Glu Asp Ile Gln Thr Asn Ile Arg Cys Asp Gln 
145                 150                 155                 160 


Gln Met Leu Leu Tyr Gly Tyr Leu Arg Gly Ala His Leu Lys Asn Lys 
                165                 170                 175     


Ser Gln Ile His Met Pro Gly Arg Gly Gly Ala His Pro 
            180                 185                 


<210>  5009
<211>  2508
<212>  DNA
<213>  Homosapiens

<400>  5009
aaataataat aataataata ataatctaca atgtcatttc ccatccaagc ttgacttcta     60

cctttacttt ctgatgtggt tttgccatgt ccccacccaa atctcatcat gaattataat    120

ccccataatc ctgatgtgtt gagggagggg cctaggggga ggtgatcaga tcacgggggc    180

agttatcctc atgctgttct tgtgatattc agtaagtcct catgagatct tatagggttt    240

tgttttgttt tgttttttag gatggagtct tgctctgttg tccaggcagg agtgccatgg    300

cacgatcttg gctcactgca gtctctgcct cttgagttcc agtaattctc ctgcctcagc    360

ctcctgagta gctgggatta caggcatgca ccaccacacc cagctaattt ttgtattttt    420

agtagagaca ggatttcact acattagcta ggctggtctc aaactcctga cctcagttga    480

tccacctgcc ttggcctccc aaagtactag ggttacaagt gtgagccacc atgcccagct    540

gagatctgat ggttttatac atgtttgaca gttgctcctt cacatgttgc cactctctgt    600

gcggccacca tgtaagtcgg acctgccctt ctgccatgat tgtaagtttc ctgaggcctc    660

cccagccatg tgaaactgag tcaattaaac ctcttccctt taaaaattac ccaacctcag    720

gtatttcttt atatcagtgt gaaaacagat tgctatactt tctgataatc atgcttaagc    780

aattggggaa ttcagactac ctgggatcaa accagggccc cacccttagc agtcatgtga    840

ccttggggag gttacttacc ttctccgtct caacaacttc tgtaaaatct gtaacatgag    900

attgtttctg agggttaaat gagcatagca cagtggggac actgtcaggc acacactact    960

tgccagatgt caagtattca tctttattga aataggactg tggtaagcca ctttatggct   1020

ctcgattctg tatgagaaaa tcatgcttag tgccttgtta gtaaaagaaa gaaaatctga   1080

aagtccctgc catggaagga agaaatagcg gggagaaaag ggagttggta agtttcagca   1140

tttcagagct tggagggaca agttaggttt ctattttatg gagaaggagg tggaggcagg   1200

atgggtccta aggtgtcatt caaaacacac agccataact ctttattgag agtagagcta   1260

gggccgcagg gattgctgtg gtcacgttgc ggacaaaaat gaccactcgt tggaagacag   1320

gagaggagtg tttagttaca aaagcagtca acaattcagg tgtatctata ttcagtcagc   1380

aaataaaagt tgttcaactt ggttgctaat gggacccact ctactgaggc tttgtataga   1440

actcatagag gaagatggct tcaagcaatg aactaccctg tgcttttctt aggactaaaa   1500

tctcaggaag ttggtgatga atgaaaacct tagtcccact ggcactgcac gaggggccag   1560

gagagcagca gcatcataag ccacagggtg gggcagccaa ggcaggggca ttctgagctg   1620

ttggggaggg gtggcaggca gggtggggca ctgtgaggtg tcggggaggg cattgtgaag   1680

tgtggggtgg ggcattctgt gccacatgcc tgggctccca cctggggcca gtgggcttca   1740

gtctgtaggt gactacagaa ggaggaggag ctccgtctgt tctctcttca ggcagttgtt   1800

gtgtctctca gcgcttgttg ggttcacaac ctattaaata agccagctgg tcttcaccct   1860

cccagacaag tcaactcagg ggaggcagca gggtgtgggc cttgacccgc agccctagcc   1920

ggggccgggg ccggggccag ggatggtgcc cggggccgcg ctgtgaggtg ggcaggcgag   1980

gagcgggaag accatctctg caagtgcagc atagcctcgg cctaggacag tgggagtgtg   2040

tggccaaagc tgtgagcaga ggcacaggtg gtggcagaca gtagaggcgc cccatgggga   2100

acatactgac ctgttgtgtg caccctagcg tcagcctcga gtttgaccag caacaggggt   2160

cggtgtgtcc ctctgaatct gagatctatg aggcaggagc tggggacagg atggcaggag   2220

cgcccatggc tgctgctgtg cagcctgctg aggtgaccgt tgaagttggt gaggacctcc   2280

acatgcacca cattcgtgac caggagatgc ctgaagcttt ggagtttagc ctttctgcca   2340

atccagaggc aagcacaata ttccagagga actctcaaac agatgctttg gagtttaacc   2400

cttctgccaa tccagaggca agcacaatat tccagaggaa ctctcaaaca gatggtgaga   2460

caacattgtt ttttccgcca agagaaagaa taaaagctct tgtttgat                2508


<210>  5010
<211>  137
<212>  PRT
<213>  Homosapiens

<400>  5010

Met Gly Asn Ile Leu Thr Cys Cys Val His Pro Ser Val Ser Leu Glu 
1               5                   10                  15      


Phe Asp Gln Gln Gln Gly Ser Val Cys Pro Ser Glu Ser Glu Ile Tyr 
            20                  25                  30          


Glu Ala Gly Ala Gly Asp Arg Met Ala Gly Ala Pro Met Ala Ala Ala 
        35                  40                  45              


Val Gln Pro Ala Glu Val Thr Val Glu Val Gly Glu Asp Leu His Met 
    50                  55                  60                  


His His Ile Arg Asp Gln Glu Met Pro Glu Ala Leu Glu Phe Ser Leu 
65                  70                  75                  80  


Ser Ala Asn Pro Glu Ala Ser Thr Ile Phe Gln Arg Asn Ser Gln Thr 
                85                  90                  95      


Asp Ala Leu Glu Phe Asn Pro Ser Ala Asn Pro Glu Ala Ser Thr Ile 
            100                 105                 110         


Phe Gln Arg Asn Ser Gln Thr Asp Gly Glu Thr Thr Leu Phe Phe Pro 
        115                 120                 125             


Pro Arg Glu Arg Ile Lys Ala Leu Val 
    130                 135         


<210>  5011
<211>  4658
<212>  DNA
<213>  Homosapiens

<400>  5011
gtgaatttcc gtttccggtg gtgtccaatc cgacctgagg agtcacagtt gtgagcaaat     60

tagaattact tgttattggt aaatagccac tatggagact aaggaccaga agaaacaaag    120

aaagaaaaat agtggaccca aagctgcaaa gaaaaagaag cggcatctgc aggatctcca    180

gctaggagac gaagaagatg cctggaagag aaatcccaaa gcttttgcat ttcagtctgc    240

tgtgtggatg gctcgatcct ttcacaggac tcaggatttg aagacaaaaa agcatcatat    300

tccagtggtt gatcgaactc cactagagcc cccaccaata gtggtagtgg tgatggggcc    360

tccaaagttg gaaagagcac tttgatacaa tgcctcattc ggaacttcac ccggcagaag    420

ttgaccgaga tcagaggccc tgtgatgatc gtgtcaggta aaaagctccg actcaccatt    480

attgaatgtg ggtgtgacat taacatgatg attgatctgg ctgaagtagc agatctggta    540

ctgatgctta tagatgccag ctttgggttt gaaatggaaa cgtttgagtt tctaaacatc    600

tgtcaagtac atggctttcc taaaattatg ggagttctca cccacctcga cttcttcaaa    660

cacaataagc aactgaagaa gacaaagaag cgattaaaac acaggttctg gacagaagtt    720

tacctggttg ccaagctgtt ctgcctttct ggaatggtgc atggagaata tcaaaaccaa    780

gaaatgcaca atctgggcca ttttattaca gttatgaagt ttaggcctct cacatggcag    840

acttctcatc cttatatcct ggcagacagg taaaaaggtg gaagatttga caaacccaga    900

ggatatccaa acaaacatca gatgtgacca gcagatgtta ctttacggtt atttaagagg    960

agcgcacttg aaaaataaaa gccaaattca catgccagga cgaggtgggg cccacccatg   1020

agctggtcca gagtctcatc tccacccact ccaccattga tgccaagatg gcttcaagtc   1080

gagtgatgtt gttttctgat tccaagccac ttgggtcaga ggctatagat aatcaagggt   1140

gagtggtgtc attgagcaaa cacgaagtcg ggctcatcca aggatgagat tttgccagag   1200

aaaggacgag cagcaagtca gggagcttaa ggtaattatg ggaaagtgac tatctacaat   1260

tgcttaggta gaaggagaca gattggattt ttgtgtgttt ggtatttggg ataagaggga   1320

tgtgggtgtg tacttgacat gggttgttct ctctctctct tttttttttt tttttttttg   1380

agagggagtc tcactctgtc acccaggctg gagttctgtg gcacagtctt ggctcactgc   1440

aacctccgcc tgccgggttc aagggattct cctgcctcag cctcccaagt agctggggtt   1500

acaggtgcct gccaccacgc cctgctaatt tttgtgattt tttttttagt agagacgagg   1560

tttcactatg taggcaaagc tggtctcgaa ctcctgacct cagatgatcc acccgcctca   1620

gcctcccaaa gtgctgggat tacaggcgtg agccaccgca cctggcctgt ttattctctt   1680

aagagagaaa atgaggggat taatggactg tagttctgga caaggtggaa aactcttaaa   1740

gtggaagtat tggggcaagt gctctgacag gctaggatgg tgcagtcagt cccttcaccc   1800

agaaatcagt agaatgttaa cagttcagac tcaaaccttg tgaaaaacag gtggtggaaa   1860

ggaaatccct cacagcaact ggcaccataa tcaagacaga atgtttgcag aataaatgga   1920

gttacctgct ttcagcccca ggttgtagct attgtctgcc ctgatgatat gtgataataa   1980

tttgtgatcc tattgtctta aaatggggtc actcatctcc agtagaatta agtccacagt   2040

gaagttgtcc ccccatcccc aaagagataa acatatatga atgaactcac atgataacaa   2100

ctactgctgc ctgggatcat gagagacctg aactgaactg ataggaagtg aaaggtggct   2160

gagataatga gaatagaccc atctgcagag gatcataaaa ccagcaaaga caagatcttg   2220

tctaagatgc cttcacaaac tttgtccatg agaactctaa ggacttctcc agacctgttg   2280

gctgctgctg tgatctctgc ccaagaggag cctctgacca acatccaaag ggcttctgga   2340

cccactggac tcctctggag gtaccttggt ctcccgatcc atggctgtgg ttttttactc   2400

cgtttatcac tcctgtgtgt agaatgataa ttgcacaatt gatagtgtga acacctcttg   2460

ataaatggta aatctgagca tatgtatttg gctgacatgt cattgtgaaa cctcacagct   2520

tcagtcagtg tcagcacagc tagggagcat gtacctaatg cacatatcac tgggcatagt   2580

ctacaggcac ctaataactc aggtacctta acagtcacta atgagtgtct ctccaaggtc   2640

aaaacaatgg aagactgtag aagatgctat tcattaagat atctcaagaa tgtggaagac   2700

tattattcgc ttctcatggg acaggacttt atagggcacc tgaaaaaact cccatgaaaa   2760

atcactttta caaaatgtca agttatgata tccaagatga aaccaatgag tcacaacatt   2820

cacataatac actgtacaac cctgatctct tgactgtcat caaatgtttc ttacctctaa   2880

accaaagttt cattttataa tttaattttt ctcatttttt ctgttctctt agcttaagaa   2940

aagatcatta caaacttttt gtatgttttt catatatgct tgcaaagggt tgtaaaactt   3000

tattgtgatt attcttgctt taagctgaaa cttccctaat ctttctttag agattgtggc   3060

atagcatgtt agtttctttt ccatatccaa ttgttttctg taatgaatac agaaatatgg   3120

gcactatttt gtaactttaa atagacatca tctcaagtct acaagaatta tccaaaatgg   3180

tatttaatga catttctagg tcttcagaca ctattaatgt agattgtagc ctctaggtcc   3240

tgaggatttt tactggatac tggttactga aactgagctt tcttgaattc tttttccttc   3300

cactgtggtt tcccgcattt caacacatca cctatttttg tcctcaaacg ttacttaaat   3360

tttttccaca gaattaaatt aaatatgaat catccctcct ctgatttttg aaatgaccct   3420

ttgcttccta tgataatgat tcttctggtc cgttttgtag ttatatgtta gagtttgtaa   3480

atattcacac attttgcaac tgcatataat tttctcattt tttcctcttc ctctaaagct   3540

gctgttattt cttttaactt tttgtgggaa aaattaaacc catctttcac tttgttgata   3600

tttataattg aactccttga tttttgcttg aattgctttt caagttaccc acttttaggg   3660

aagacattat ttgggttttg tttagtgtat caggcttttt ttagttagtt gtatcaagaa   3720

gtgtagactt ttctatacat aatatccttt ttcccacagt agtttttttt tttttaaagt   3780

ctagccgggt gcagtggctc acgcctgtaa tcccagactt tgggaggccg aggtgggcag   3840

atcacgaagt caagagaccg agaacatcct ggctaacaca gtgaaacccc gtctctacta   3900

aaaatacaaa aaattagccg gacatggtaa cgggtgcctg tagtcccagc taatcaggag   3960

gctgaggcag gagaatgaca tgaactcagg aggcagaggt tgcagtgagc cgagatcgtg   4020

ccactgcact ccagcctggg tgacagagca agactccatc tcaaaaaaaa aaaaaaaaaa   4080

aaagtctgtt aaaataaagg tcatcaaaag atcttttcct aaacctttcc tttaccagaa   4140

atatctctag agtcacatgg tcctttctcc cttcttgctt ttgtaggagt ccaaagctaa   4200

tctgtccctg atccggattg catgcacctg tgccttttgg ggcccttctg cattagttct   4260

tccttctctt ctaacctcaa aaatgtgttt tctctgttgg ctctttccct ttaacataga   4320

agtatactca cgcttttgtt gaatcttgga ataaaagtct tcctttacca catatctccc   4380

tttaatacta catctctctt ctcagccaaa tacttgggaa gacaagccct gagtttgtgt   4440

gattgttttc tcacctccag ttcactactt tgaacaggca ctgtgctagg tgctgctgtt   4500

atagatatga aaagaaggca tcatctcctt tctaacaact cataggagca gccattcctg   4560

attcatacgc aggtctcttg attctcagtg ctcacttttg caagcttcac ttaatgccgt   4620

gtaaatcacc ctattctcca ggtcttcttt cttcccag                           4658


<210>  5012
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  5012

Met Ile Val Ser Gly Lys Lys Leu Arg Leu Thr Ile Ile Glu Cys Gly 
1               5                   10                  15      


Cys Asp Ile Asn Met Met Ile Asp Leu Ala Glu Val Ala Asp Leu Val 
            20                  25                  30          


Leu Met Leu Ile Asp Ala Ser Phe Gly Phe Glu Met Glu Thr Phe Glu 
        35                  40                  45              


Phe Leu Asn Ile Cys Gln Val His Gly Phe Pro Lys Ile Met Gly Val 
    50                  55                  60                  


Leu Thr His Leu Asp Phe Phe Lys His Asn Lys Gln Leu Lys Lys Thr 
65                  70                  75                  80  


Lys Lys Arg Leu Lys His Arg Phe Trp Thr Glu Val Tyr Leu Val Ala 
                85                  90                  95      


Lys Leu Phe Cys Leu Ser Gly Met Val His Gly Glu Tyr Gln Asn Gln 
            100                 105                 110         


Glu Met His Asn Leu Gly His Phe Ile Thr Val Met Lys Phe Arg Pro 
        115                 120                 125             


Leu Thr Trp Gln Thr Ser His Pro Tyr Ile Leu Ala Asp Arg 
    130                 135                 140         


<210>  5013
<211>  3479
<212>  DNA
<213>  Homosapiens

<400>  5013
gtggtgtcca atccgacctg aggagtcaca gttgtgagca agttcggtgc cgcgggctgg     60

gattagaatt acttgttatt ggtaaatagc cactatggag actaaggacc agaagaaaca    120

aagaaagaaa aatagtggac ccaaagctgc aaagaaaaag aagcggcatc tgcaggatct    180

ccagctagga gacgaagaag atgcctggaa gagaaatccc aaagcttttg catttcagtc    240

tgctgtgtgg atggctcgat cctttcacag gactcaggat ttgaagacaa aaaagcatca    300

tattccagtg gttgatcgaa ctccactaga gcccccacca atagtggtag tggtgatggg    360

gcctccaaag ttggaaagag cactttgata caatgcctca ttcggaactt cacccggcag    420

aagttgaccg agatcagagg ccctgtgatg atcgtgtcag gtaaaaagct ccgactcacc    480

attattgaat gtgggtgtga cattaacatg atgattgatc tggctgaagt agcagatctg    540

gtactgatgc ttatagatgc cagctttggg tttgaaatgg aaacgtttga gtttctaaac    600

atctgtcaag tacatggctt tcctaaaatt atgggagttc tcacccacct cgacttcttc    660

aaacacaata agcaactgaa gaagacaaag aagcgattaa aacacaggtt ctggacagaa    720

gtttacctgg ttgccaagct gttctgcctt tctggaatgg tgcatggaga atatcaaaac    780

caagaaatgc acaatctggg ccattttatt acagttatga agtttaggcc tctcacatgg    840

cagacttctc atccttatat cctggcagac agggtggaag atttgacaaa cccagaggat    900

atccaaacaa acatcagatg tgaccagcag atgttacttt acggttattt aagaggagcg    960

cacttgaaaa ataaaagcca aattcacatg ccaggacgag gtggggccca cccatgagct   1020

ggtccagagt ctcatctcca cccactccac cattgatgcc aagatggctt caagtcgagt   1080

gatgttgttt tctgattcca agccacttgg gtcagaggct atagataatc aaggggacga   1140

gttctcacta tgttgcccag gctggcctcg aactcctggg ctcaagcaat cctcctgcgt   1200

tggcctccca aagtcctggg attacaggtg taagccacta cggctggcct attattgctg   1260

tattctaact tattcatctc ctatgtgtca gagatggctt tggattcccc gttctgtgtg   1320

ctgctgtctg gctcctgaac ccagctgtag aggtgtgtca atcccaactg gtgaagtact   1380

gagaggaagc tacacaaaag gcagcaaagt attagtgagt ggtgtcattg agcaaacacg   1440

aagtcgggct catccaagga tgagattttg ccagagaaag gacgagcagc aagtcaggga   1500

gcttaaggta attatgggaa agtgactatc tacaattgct taggtagaag gagacagatt   1560

ggatttttgt gtgtttggta tttgggataa gagggatcct gggtgacaga gcaagactcc   1620

atctcaaaaa aaaaaaaaaa aaaaaagtct gttaaaataa aggtcatcaa aagatctttt   1680

cctaaacctt tcctttacca gaaatatctc tagagtcaca tggtcctttc tcccttcttg   1740

cttttgtagg agtccaaagc taatctgtcc ctgatccgga ttgcatgcac ctgtgccttt   1800

tggggccctt ctgcattagt tcttccttct cttctaacct caaaaatgtg ttttctctgt   1860

tggctctttc cctttaacat agaagtatac tcacgctttt gttgaatctt ggaataaaag   1920

tcttccttta ccacatatct ccctttaata ctacatctct cttctcagcc aaatacttgg   1980

gaagacaagc cctgagtttg tgtgattgtt ttctcacctc cagttcacta ctttgaacag   2040

gcactgtgct aggtgctgct gttatagata tgaaaagaag gcatcatctc ctttctaaca   2100

actcatagga gcagccattc ctgattcata cgcaggtctc ttgattctca gtgctcactt   2160

ttgcaagctt cacttaatgc cgtgtaaatc accctattct ccaggtcttc tttcttccca   2220

gttctcctta ctatacacaa cttctcaagg cagtcacctc cacgcccatg gcttcaattg   2280

ctttctccat tctctgagaa caatagaatt ttaaatgttt ttttttcatg tattagtttt   2340

attttataca aggtgtctca cttgctgtaa ccatagattc aaagttgctc catgaaacta   2400

ataaatgaaa aatggtgatt ttttagcatg taaattttag gaaatttccc cagttacact   2460

taatggcttg atttagtatg ttatttttga aaacatatgt tgggatgtca caaatggact   2520

tagcctacag agatttatat tcaacttttg accagagagt tccattttaa tgtgacactg   2580

agagtaaaaa actatctttt cctccttacc tatttctctt cctacattct cggccaggag   2640

gaaggcactg ctacataccc agtcttcccc agcagagcct gagcagctct gttttccttc   2700

tacttcccct cttctttcac atctcatgac caagcacttc ctattctgtc tcccaaatga   2760

tcacagattt tttcctccac ttttgtcact gccactgccc ttagcattac tctgccttta   2820

gagaaagtct cttaattggt ttggttgctt ccttcagtcc ttattataca gaccactaca   2880

cacacatctg acagagactt ttcacctttt tatggttcaa tgactgaaat tcccagaata   2940

aaattaaaac caccccagca tcaaatttga ggtcaaatag aggtggattt gtatcccagg   3000

ttcatatact atccagcagt atggtctcag aaaactgacc tccttaagcc tttgtttgtg   3060

tatctgccta cactcattga gagttgggac tatttcacac atacagtgcc tggcatgtag   3120

aagggactta atcaatgttg aaagaagggg aggcatttta aaatccacat caaaaaaatg   3180

ttgttctgtt cgggagtggt ggctcatgcc tgcaatccca gcactttggg aggccaaggc   3240

aggtggatca cctgaggtca ggagttcgag atcaacctga gcaacatggt gaaaccccat   3300

ctctactaaa aatacaaaca ttagctgagc atgggggcgg gatcctgtaa tctcagctac   3360

ttgggaggct taggcacttg aatgagaatc acttggaccc aggaggtgga ggttgcagtg   3420

ggcaatgatt gtgccactgc ctgggcaaca gagtgagact ctgtctcaaa aaaaaaaaa    3479


<210>  5014
<211>  189
<212>  PRT
<213>  Homosapiens

<400>  5014

Met Ile Val Ser Gly Lys Lys Leu Arg Leu Thr Ile Ile Glu Cys Gly 
1               5                   10                  15      


Cys Asp Ile Asn Met Met Ile Asp Leu Ala Glu Val Ala Asp Leu Val 
            20                  25                  30          


Leu Met Leu Ile Asp Ala Ser Phe Gly Phe Glu Met Glu Thr Phe Glu 
        35                  40                  45              


Phe Leu Asn Ile Cys Gln Val His Gly Phe Pro Lys Ile Met Gly Val 
    50                  55                  60                  


Leu Thr His Leu Asp Phe Phe Lys His Asn Lys Gln Leu Lys Lys Thr 
65                  70                  75                  80  


Lys Lys Arg Leu Lys His Arg Phe Trp Thr Glu Val Tyr Leu Val Ala 
                85                  90                  95      


Lys Leu Phe Cys Leu Ser Gly Met Val His Gly Glu Tyr Gln Asn Gln 
            100                 105                 110         


Glu Met His Asn Leu Gly His Phe Ile Thr Val Met Lys Phe Arg Pro 
        115                 120                 125             


Leu Thr Trp Gln Thr Ser His Pro Tyr Ile Leu Ala Asp Arg Val Glu 
    130                 135                 140                 


Asp Leu Thr Asn Pro Glu Asp Ile Gln Thr Asn Ile Arg Cys Asp Gln 
145                 150                 155                 160 


Gln Met Leu Leu Tyr Gly Tyr Leu Arg Gly Ala His Leu Lys Asn Lys 
                165                 170                 175     


Ser Gln Ile His Met Pro Gly Arg Gly Gly Ala His Pro 
            180                 185                 


<210>  5015
<211>  3752
<212>  DNA
<213>  Homosapiens

<400>  5015
gtgaatttcc gtttccggtg gtgtccaatc cgacctgagg agtcacagtt gtgagcaaat     60

tagaattact tgttattggt aaatagccac tatggagact aaggaccaga agaaacaaag    120

aaagaaaaat agtggaccca aagctgcaaa gaaaaagaag cggcatctgc aggatctcca    180

gctaggagac gaagaagatg cctggaagag aaatcccaaa gcttttgcat ttcagtctgc    240

tgtgtggatg gctcgatcct ttcacaggac tcaggatttg aagacaaaaa agcatcatat    300

tccagtggtt gatcgaactc cactagagcc cccaccaata gtggtagtgg tgatggggcc    360

tccaaagttg gaaagagcac tttgatacaa tgcctcattc ggaacttcac ccggcagaag    420

ttgaccgaga tcagaggccc tgtgatgatc gtgtcaggta aaaagctccg actcaccatt    480

attgaatgtg ggtgtgacat taacatgatg attgatctgg ctgaagtagc agatctggta    540

ctgatgctta tagatgccag ctttgggttt gaaatggaaa cgtttgagtt tctaaacatc    600

tgtcaagtac atggctttcc taaaattatg ggagttctca cccacctcga cttcttcaaa    660

cacaataagc aactgaagaa gacaaagaag cgattaaaac acaggttctg gacagaagtt    720

tacctggttg ccaagctgtt ctgcctttct ggaatggtgc atggagaata tcaaaaccaa    780

gaaatgcaca atctgggcca ttttattaca gttatgaagt ttaggcctct cacatggcag    840

acttctcatc cttatatcct ggcagacagg gtggaagatt tgacaaaccc agaggatatc    900

caaacaaaca tcagatgtga ccagcagatg ttactttacg gttatttaag aggagcgcac    960

ttgaaaaata aaagccaaat tcacatgcca ggacgaggtg gggcccaccc atgagctggt   1020

ccagagtctc atctccaccc actccaccat tgatgccaag atggcttcaa gtcgagtgat   1080

gttgttttct gattccaagc cacttgggtc agaggctata gataatcaag gggacgagtt   1140

ctcactatgt tgcccaggct ggcctcgaac tcctgggctc aagcaatcct cctgcgttgg   1200

cctcccaaag tcctgggatt acaggtgtaa gccactacgg ctggcctatt attgctgtat   1260

tctaacttat tcatctccta tgtgtcagag atggctttgg attccccgtt ctgtgtgctg   1320

ctgtctggct cctgaaccca gctgtagagg tgtgtcaatc ccaactggtg aagtactgag   1380

aggaagctac acaaaaggca gcaaagtatt agtgagtggt gtcattgagc aaacacgaag   1440

tcgggctcat ccaaggatga gattttgcca gagaaaggac gagcagcaag tcagggagct   1500

taaggatgga gtcttgctct gttgtccagg caggagtgcc atggcacgat cttggctcac   1560

tgcagtctct gcctcttgag ttccagtaat tctcctgcct cagcctcctg agtagctggg   1620

attacaggca tgcaccacca cacccagcta atttttgtat ttttagtaga gacaggattt   1680

cactacatta gctaggctgg tctcaaactc ctgacctcag ttgatccacc tgccttggcc   1740

tcccaaagta ctagggttac aagtgtgagc caccatgccc agctgagatc tgatggtttt   1800

atacatgttt gacagttgct ccttcacatg ttgccactct ctgtgcggcc accatgtaag   1860

tcggacctgc ccttctgcca tgattgtaag tttcctgagg cctccccagc catgtgaaac   1920

tgagtcaatt aaacctcttc cctttaaaaa ttacccaacc tcaggtattt ctttatatca   1980

gtgtgaaaac agattgctat actttctgat aatcatgctt aagcaattgg ggaattcaga   2040

ctacctggga tcaaaccagg gccccaccct tagcagtcat gtgaccttgg ggaggttact   2100

taccttctcc gtctcaacaa cttctgtaaa atctgtaaca tgagattgtt tctgagggtt   2160

aaatgagcat agcacagtgg ggacactgtc aggcacacac tacttgccag atgtcaagta   2220

ttcatcttta ttgaaatagg actgtggtaa gccactttat ggctctcgat tctgtatgag   2280

aaaatcatgc ttagtgcctt gttagtaaaa gaaagaaaat ctgaaagtcc ctgccatgga   2340

aggaagaaat agcggggaga aaagggagtt ggtaagtttc agcatttcag agcttggagg   2400

gacaagttag gtttctattt tatggagaag gaggtggagg caggatgggt cctaaggtgt   2460

cattcaaaac acacagccat aactctttat tgagagtaga gctagggccg cagggattgc   2520

tgtggtcacg ttgcggacaa aaatgaccac tcgttggaag acaggagagg agtgtttagt   2580

tacaaaagca gtcaacaatt caggtgtatc tatattcagt cagcaaataa aagttgttca   2640

acttggttgc taatgggacc cactctactg aggctttgta tagaactcat agaggaagat   2700

ggcttcaagc aatgaactac cctgtgcttt tcttaggact aaaatctcag gaagttggtg   2760

atgaatgaaa accttagtcc cactggcact gcacgagggg ccaggagagc agcagcatca   2820

taagccacag ggtggggcag ccaaggcagg ggcattctga gctgttgggg aggggtggca   2880

ggcagggtgg ggcactgtga ggtgtcgggg agggcattgt gaagtgtggg gtggggcatt   2940

ctgtgccaca tgcctgggct cccacctggg gccagtgggc ttcagtctgt aggtgactac   3000

agaaggagga ggagctccgt ctgttctctc ttcaggcagt tgttgtgtct ctcagcgctt   3060

gttgggttca caacctatta aataagccag ctggtcttca ccctcccaga caagtcaact   3120

caggggaggc agcagggtgt gggccttgac ccgcagccct agccggggcc ggggccgggg   3180

ccagggatgg tgcccggggc cgcgctgtga ggtgggcagg cgaggagcgg gaagaccatc   3240

tctgcaagtg cagcatagcc tcggcctagg acagtgggag tgtgtggcca aagctgtgag   3300

cagaggcaca ggtggtggca gacagtagag gcgccccatg gggaacatac tgacctgttg   3360

tgtgcaccct agcgtcagcc tcgagtttga ccagcaacag gggtcggtgt gtccctctga   3420

atctgagatc tatgaggcag gagctgggga caggatggca ggagcgccca tggctgctgc   3480

tgtgcagcct gctgaggtga ccgttgaagt tggtgaggac ctccacatgc accacattcg   3540

tgaccaggag atgcctgaag ctttggagtt tagcctttct gccaatccag aggcaagcac   3600

aatattccag aggaactctc aaacagatgc tttggagttt aacccttctg ccaatccaga   3660

ggcaagcaca atattccaga ggaactctca aacagatggt gagacaacat tgttttttcc   3720

gccaagagaa agaataaaag ctcttgtttg at                                 3752


<210>  5016
<211>  189
<212>  PRT
<213>  Homosapiens

<400>  5016

Met Ile Val Ser Gly Lys Lys Leu Arg Leu Thr Ile Ile Glu Cys Gly 
1               5                   10                  15      


Cys Asp Ile Asn Met Met Ile Asp Leu Ala Glu Val Ala Asp Leu Val 
            20                  25                  30          


Leu Met Leu Ile Asp Ala Ser Phe Gly Phe Glu Met Glu Thr Phe Glu 
        35                  40                  45              


Phe Leu Asn Ile Cys Gln Val His Gly Phe Pro Lys Ile Met Gly Val 
    50                  55                  60                  


Leu Thr His Leu Asp Phe Phe Lys His Asn Lys Gln Leu Lys Lys Thr 
65                  70                  75                  80  


Lys Lys Arg Leu Lys His Arg Phe Trp Thr Glu Val Tyr Leu Val Ala 
                85                  90                  95      


Lys Leu Phe Cys Leu Ser Gly Met Val His Gly Glu Tyr Gln Asn Gln 
            100                 105                 110         


Glu Met His Asn Leu Gly His Phe Ile Thr Val Met Lys Phe Arg Pro 
        115                 120                 125             


Leu Thr Trp Gln Thr Ser His Pro Tyr Ile Leu Ala Asp Arg Val Glu 
    130                 135                 140                 


Asp Leu Thr Asn Pro Glu Asp Ile Gln Thr Asn Ile Arg Cys Asp Gln 
145                 150                 155                 160 


Gln Met Leu Leu Tyr Gly Tyr Leu Arg Gly Ala His Leu Lys Asn Lys 
                165                 170                 175     


Ser Gln Ile His Met Pro Gly Arg Gly Gly Ala His Pro 
            180                 185                 


<210>  5017
<211>  4221
<212>  DNA
<213>  Homosapiens

<400>  5017
aggagtcaca gttgtgagca agttcggtgc cgcgggctgg ggtaggcggc agtggggtcc     60

ctggctttgg ggcactggga agatcgcgag tgggaaggtc ctcccgcggt cctccgggtc    120

atctttcctc ctgaggagca gcatatttcg catctgccgg agattagaat tacttgttat    180

tggtaaatag ccactatgga gactaaggac cagaagaaac aaagaaagaa aaatagtgga    240

cccaaagctg caaagaaaaa gaagcggcat ctgcaggatc tccagctagg agacgaagaa    300

gatgcctgga agagaaatcc caaagctttt gcatttcagt ctgctgtgtg gatggctcga    360

tcctttcaca ggactcagga tttgaagaca aaaaagcatc atattccagt ggttgatcga    420

actccactag agcccccacc aatagtggta gtggtgatgg ggcctccaaa gttggaaaga    480

gcactttgat acaatgcctc attcggaact tcacccggca gaagttgacc gagatcagag    540

gccctgtgat gatcgtgtca ggtaaaaagc tccgactcac cattattgaa tgtgggtgtg    600

acattaacat gatgattgat ctggctgaag tagcagatct ggtactgatg cttatagatg    660

ccagctttgg gtttgaaatg gaaacgtttg agtttctaaa catctgtcaa gtacatggct    720

ttcctaaaat tatgggagtt ctcacccacc tcgacttctt caaacacaat aagcaactga    780

agaagacaaa gaagcgatta aaacacaggt tctggacaga agtttacctg gttgccaagc    840

tgttctgcct ttctggaatg gtgcatggag aatatcaaaa ccaagaaatg cacaatctgg    900

gccattttat tacagttatg aagtttaggc ctctcacatg gcagacttct catccttata    960

tcctggcaga caggtaaaaa ggtggaagat ttgacaaacc cagaggatat ccaaacaaac   1020

atcagatgtg accagcagat gttactttac ggttatttaa gaggagcgca cttgaaaaat   1080

aaaagccaaa ttcacatgcc aggacgaggt ggggcccacc catgagctgg tccagagtct   1140

catctccacc cactccacca ttgatgccaa gatggcttca agtcgagtga tgttgttttc   1200

tgattccaag ccacttgggt cagaggctat agataatcaa gggtgagtgg tgtcattgag   1260

caaacacgaa gtcgggctca tccaaggatg agattttgcc agagaaagga cgagcagcaa   1320

gtcagggagc ttaaggtaat tatgggaaag tgactatcta caattgctta ggtagaagga   1380

gacagattgg atttttgtgt gtttggtatt tgggataaga gggatgtggg tgtgtacttg   1440

acatgggttg ttctctctct ctcttttttt tttttttttt tttgagaggg agtctcactc   1500

tgtcacccag gctggagttc tgtggcacag tcttggctca ctgcaacctc cgcctgccgg   1560

gttcaaggga ttctcctgcc tcagcctccc aagtagctgg ggttacaggt gcctgccacc   1620

acgccctgct aatttttgtg attttttttt tagtagagac gaggtttcac tatgtaggca   1680

aagctggtct cgaactcctg acctcagatg atccacccgc ctcagcctcc caaagtgctg   1740

ggattacagg cgtgagccac cgcacctggc ctgtttattc tcttaagaga gaaaatgagg   1800

ggattaatgg actgtagttc tggacaaggt ggaaaactct taaagtggaa gtattggggc   1860

aagtgctctg acaggctagg atggtgcagt cagtcccttc acccagaaat cagtagaatg   1920

ttaacagttc agactcaaac cttgtgaaaa acaggtggtg gaaaggaaat ccctcacagc   1980

aactggcacc ataatcaaga cagaatgttt gcagaataaa tggagttacc tgctttcagc   2040

cccaggttgt agctattgtc tgccctgatg atatgtgata ataatttgtg atcctattgt   2100

cttaaaatgg ggtcactcat ctccagtaga attaagtcca cagtgaagtt gtccccccat   2160

ccccaaagag ataaacatat atgaatgaac tcacatgata acaactactg ctgcctggga   2220

tcatgagaga cctgaactga actgatagga agtgaaaggt ggctgagata atgagaatag   2280

acccatctgc agaggatcat aaaaccagca aagacaagat cttgtctaag atgccttcac   2340

aaactttgtc catgagaact ctaaggactt ctccagacct gttggctgct gctgtgatct   2400

ctgcccaaga ggagcctctg accaacatcc aaagggcttc tggacccact ggactcctct   2460

ggaggtacct tggtctcccg atccatggct gtggtttttt actccgttta tcactcctgt   2520

gtgtagaatg ataattgcac aattgatagt gtgaacacct cttgataaat ggtaaatctg   2580

agcatatgta tttggctgac atgtcattgt gaaacctcac agcttcagtc agtgtcagca   2640

cagctaggga gcatgtacct aatgcacata tcactgggca tagtctacag gcacctaata   2700

actcaggtac cttaacagtc actaatgagt gtctctccaa ggtcaaaaca atggaagact   2760

gtagaagatg ctattcatta agatatctca agaatgtgga agactattat tcgcttctca   2820

tgggacagga ctttataggg cacctgaaaa aactcccatg aaaaatcact tttacaaaat   2880

gtcaagttat gatatccaag atgaaaccaa tgagtcacaa cattcacata atacactgta   2940

caaccctgat ctcttgactg tcatcaaatg tttcttacct ctaaaccaaa gtttcatttt   3000

ataatttaat ttttctcatt ttttctgttc tcttagctta agaaaagatc attacaaact   3060

ttttgtatgt ttttcatata tgcttgcaaa gggttgtaaa actttattgt gattattctt   3120

gctttaagct gaaacttccc taatctttct ttagagattg tggcatagca tgttagtttc   3180

ttttccatat ccaattgttt tctgtaatga atacagaaat atgggcacta ttttgtaact   3240

ttaaatagac atcatctcaa gtctacaaga attatccaaa atggtattta atgacatttc   3300

taggtcttca gacactatta atgtagattg tagcctctag gtcctgagga tttttactgg   3360

atactggtta ctgaaactga gctttcttga attctttttc cttccactgt ggtttcccgc   3420

atttcaacac atcacctatt tttgtcctca aacgttactt aaattttttc cacagaatta   3480

aattaaatat gaatcatccc tcctctgatt tttgaaatga ccctttgctt cctatgataa   3540

tgattcttct ggtccgtttt gtagttatat gttagagttt gtaaatattc acacattttg   3600

caactgcata taattttctc attttttcct cttcctctaa agctgctgtt atttctttta   3660

actttttgtg ggaaaaatta aacccatctt tcactttgtt gatatttata attgaactcc   3720

ttgatttttg cttgaattgc ttttcaagtt acccactttt agggaagaca ttatttgggt   3780

tttgtttagt gtatcaggct ttttttagtt agttgtatca agaagtgtag acttttctat   3840

acataatatc ctttttccca cagtagtttt ttttttttta aagtctagcc gggtgcagtg   3900

gctcacgcct gtaatcccag actttgggag gccgaggtgg gcagatcacg aagtcaagag   3960

accgagaaca tcctggctaa cacagtgaaa ccccgtctct actaaaaata caaaaaatta   4020

gccggacatg gtaacgggtg cctgtagtcc cagctaatca ggaggctgag gcaggagaat   4080

gacatgaact caggaggcag aggttgcagt gagccgagat cgtgccactg cactccagcc   4140

tgggtgacag agcaagactc catctcaaaa aaaaaaaaaa aaaaaaagtc tgttaaaata   4200

aaggtcatca aaagatcttt t                                             4221


<210>  5018
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  5018

Met Ile Val Ser Gly Lys Lys Leu Arg Leu Thr Ile Ile Glu Cys Gly 
1               5                   10                  15      


Cys Asp Ile Asn Met Met Ile Asp Leu Ala Glu Val Ala Asp Leu Val 
            20                  25                  30          


Leu Met Leu Ile Asp Ala Ser Phe Gly Phe Glu Met Glu Thr Phe Glu 
        35                  40                  45              


Phe Leu Asn Ile Cys Gln Val His Gly Phe Pro Lys Ile Met Gly Val 
    50                  55                  60                  


Leu Thr His Leu Asp Phe Phe Lys His Asn Lys Gln Leu Lys Lys Thr 
65                  70                  75                  80  


Lys Lys Arg Leu Lys His Arg Phe Trp Thr Glu Val Tyr Leu Val Ala 
                85                  90                  95      


Lys Leu Phe Cys Leu Ser Gly Met Val His Gly Glu Tyr Gln Asn Gln 
            100                 105                 110         


Glu Met His Asn Leu Gly His Phe Ile Thr Val Met Lys Phe Arg Pro 
        115                 120                 125             


Leu Thr Trp Gln Thr Ser His Pro Tyr Ile Leu Ala Asp Arg 
    130                 135                 140         


<210>  5019
<211>  5520
<212>  DNA
<213>  Homosapiens

<400>  5019
gtgaatttcc gtttccggtg gtgtccaatc cgacctgagg agtcacagtt gtgagcaaat     60

tagaattact tgttattggt aaatagccac tatggagact aaggaccaga agaaacaaag    120

aaagaaaaat agtggaccca aagctgcaaa gaaaaagaag cggcatctgc aggatctcca    180

gctaggagac gaagaagatg cctggaagag aaatcccaaa gcttttgcat ttcagtctgc    240

tgtgtggatg gctcgatcct ttcacaggac tcaggatttg aagacaaaaa agcatcatat    300

tccagtggtt gatcgaactc cactagagcc cccaccaata gtggtagtgg tgatggggcc    360

tccaaagttg gaaagagcac tttgatacaa tgcctcattc ggaacttcac ccggcagaag    420

ttgaccgaga tcagaggccc tgtgatgatc gtgtcaggta aaaagctccg actcaccatt    480

attgaatgtg ggtgtgacat taacatgatg attgatctgg ctgaagtagc agatctggta    540

ctgatgctta tagatgccag ctttgggttt gaaatggaaa cgtttgagtt tctaaacatc    600

tgtcaagtac atggctttcc taaaattatg ggagttctca cccacctcga cttcttcaaa    660

cacaataagc aactgaagaa gacaaagaag cgattaaaac acaggttctg gacagaagtt    720

tacctggttg ccaagctgtt ctgcctttct ggaatggtgc atggagaata tcaaaaccaa    780

gaaatgcaca atctgggcca ttttattaca gttatgaagt ttaggcctct cacatggcag    840

acttctcatc cttatatcct ggcagacagg gtggaagatt tgacaaaccc agaggatatc    900

caaacaaaca tcagatgtga ccagcagatg ttactttacg gttatttaag aggagcgcac    960

ttgaaaaata aaagccaaat tcacatgcca ggacgaggtg gggcccaccc atgagctggt   1020

ccagagtctc atctccaccc actccaccat tgatgccaag atggcttcaa gtcgagtgat   1080

gttgttttct gattccaagc cacttgggtc agaggctata gataatcaag gggacgagtt   1140

ctcactatgt tgcccaggct ggcctcgaac tcctgggctc aagcaatcct cctgcgttgg   1200

cctcccaaag tcctgggatt acaggtgtaa gccactacgg ctggcctatt attgctgtat   1260

tctaacttat tcatctccta tgtgtcagag atggctttgg attccccgtt ctgtgtgctg   1320

ctgtctggct cctgaaccca gctgtagagg tgtgtcaatc ccaactggtg aagtactgag   1380

aggaagctac acaaaaggca gcaaagtatt agtgagtggt gtcattgagc aaacacgaag   1440

tcgggctcat ccaaggatga gattttgcca gagaaaggac gagcagcaag tcagggagct   1500

taaggatgga gtcttgctct gttgtccagg caggagtgcc atggcacgat cttggctcac   1560

tgcagtctct gcctcttgag ttccagtaat tctcctgcct cagcctcctg agtagctggg   1620

attacaggca tgcaccacca cacccagcta atttttgtat ttttagtaga gacaggattt   1680

cactacatta gctaggctgg tctcaaactc ctgacctcag ttgatccacc tgccttggcc   1740

tcccaaagta ctagggttac aagtgtgagc caccatgccc agctgagatc tgatggtttt   1800

atacatgttt gacagttgct ccttcacatg ttgccactct ctgtgcggcc accatgtaag   1860

tcggacctgc ccttctgcca tgattgtaag tttcctgagg cctccccagc catgtgaaac   1920

tgagtcaatt aaacctcttc cctttaaaaa ttacccaacc tcaggtattt ctttatatca   1980

gtgtgaaaac agattgctat actttctgat aatcatgctt aagcaattgg ggaattcaga   2040

ctacctggga tcaaaccagg gccccaccct tagcagtcat gtgaccttgg ggaggttact   2100

taccttctcc gtctcaacaa cttctgtaaa atctgtaaca tgagattgtt tctgagggtt   2160

aaatgagcat agcacagtgg ggacactgtc aggcacacac tacttgccag atgtcaagta   2220

ttcatcttta ttgaaatagg actgtggtaa gccactttat ggctctcgat tctgtatgag   2280

aaaatcatgc ttagtgcctt gttagtaaaa gaaagaaaat ctgaaagtcc ctgccatgga   2340

aggaagaaat agcggggaga aaagggagtt ggtaagtttc agcatttcag agcttggagg   2400

gacaagttag gtttctattt tatggagaag gaggtggagg caggatgggt cctaaggtgt   2460

cattcaaaac acacagccat aactctttat tgagagtaga gctagggccg cagggattgc   2520

tgtggtcacg ttgcggacaa aaatgaccac tcgttggaag acaggagagg agtgtttagt   2580

tacaaaagca gtcaacaatt caggtgtatc tatattcagt cagcaaataa aagttgttca   2640

acttggttgc taatgggacc cactctactg aggctttgta tagaactcat agaggaagat   2700

ggcttcaagc aatgaactac cctgtgcttt tcttaggact aaaatctcag gaagttggtg   2760

atgaatgaaa accttagtcc cactggcact gcacgagggg ccaggagagc agcagcatca   2820

taagccacag ggtggggcag ccaaggcagg ggcattctga gctgttgggg aggggtggca   2880

ggcagggtgg ggcactgtga ggtgtcgggg agggcattgt gaagtgtggg gtggggcatt   2940

ctgtgccaca tgcctgggct cccacctggg gccagtgggc ttcagtctgt aggtgactac   3000

agaaggagga ggagctccgt ctgttctctc ttcaggcagt tgttgtgtct ctcagcgctt   3060

gttgggttca caacctatta aataagccag ctggtcttca ccctcccaga caagtcaact   3120

caggggaggc agcagggtgt gggccttgac ccgcagccct agccggggcc ggggccgggg   3180

ccagggatgg tgcccggggc cgcgctgtga ggtgggcagg cgaggagcgg gaagaccatc   3240

tctgcaagtg cagcatagcc tcggcctagg acagtgggag tgtgtggcca aagctgtgag   3300

cagaggcaca ggtggtggca gacagtagag gcgccccatg gggaacatac tgacctgttg   3360

tgtgcaccct agcgtcagcc tcgagtttga ccagcaacag gggtcggtgt gtccctctga   3420

atctgagatc tatgaggcag gagctgggga caggatggca ggagcgccca tggctgctgc   3480

tgtgcagcct gctgaggtga ccgttgaagt tggtgaggac ctccacatgc accacattcg   3540

tgaccaggag atgcctgaag gtaaggaggt gataggtgcc atctaccctc ggtttgcctc   3600

tggctgctgc tgtccccaag gttcccttta cggcatcccc cactttgagc tcctttctgc   3660

ttgtagccag ctttcccggg ggctggccag gaacaaaagc tggctctgcc ttgaattccc   3720

accccttagt ctttcctcac cgagtccagt cagtttcttt tcgcctcccc tcccaatcgc   3780

ccagttcttg ctctctcatc tcattctccc aggctggcat gggaccattt atttatggct   3840

cttgtcaaat aagcagcagt tgaataaatg agttgataaa tttttataaa tgattacatc   3900

ttttttcttt tctccctcta tacatatagc tttggagttt agcctttctg ccaatccaga   3960

ggcaagcaca atattccaga ggaactctca aacagatggt gagacaacag tgtctgtagc   4020

tctgtttatt atcctgtggg actttgttta ggcttctttg agctattctc ttccttttct   4080

caataaaaac tcaaatatcc caacttttca gtacccatct tattttttct ttgtacctat   4140

ccagatggta cctaagtgaa ggaaccaggt aagtgcctaa ttgtttcctt tgttaaagta   4200

gccaaatctc aggacagttc ctattcaaat atttgggggt ttcttattta aaatcagaat   4260

ggaggttgcc acgggagagg ctatatggta ttcttaatgg gctgctttaa gtcaccttga   4320

tagaagctgc ttagtttctt ctaactgtaa tttgaacaca gaaggaaaaa gaaaaaagag   4380

tgcttaaaat aattgtgaaa ggtgtgaaat gtcacagccg gggctgcaga aaaatggttg   4440

tgtgtgtgtg tttggggttt ctcaaaggag tttacctatg aggctctgat tactttaaaa   4500

ttcttacttt aacagaaaat gtgtctccag atttatgctg gtgacttaac agactttatt   4560

tacctccttg ttctaaaaga gaggtgggga ttggttcatg gtcaacactt tcaaaagaca   4620

tgaaatgtca atgtagactt ttaatatgta atataaagat tgcaggttaa aatgtcagac   4680

cttccctgta agagtgtttg ttgccgtggc tccccctttg tcccttcccc tcctgacaat   4740

agcatcttgt tcaaagataa gaaagttaca gttttggctg ggcttggtgg ctcacgcctg   4800

taatcccagc actttgggag gccgtggcag gcagatcacc tgaggtcagg agttcgagac   4860

cagcctggcc aacatggtga aacgctgtct ctactaaaaa aaaaatacaa aaattagctg   4920

ggtgtagtgg cgcatgactg tagttccacc tactcacaag gctgaggcag gagaattgcc   4980

tggacctggg aggtggaggt tgcagtgagc agagatcacg ccaatgcact ccagcctggg   5040

tgacagagcg agactccgtc tcacaaaaaa aaaaaaggaa agaaagttgg agttttttag   5100

tctctacact gctggcagag gcaggggatg ggagctggta gaaaagagaa aacaattagt   5160

tggtttgcct ctaaaatttt gcaaagagat gaatctaagt aaaagtaatt ctgggtaata   5220

atatggttct tgaataaaaa ctgaaatttt caaaatagaa aacattgcat cataaacata   5280

ttaaatccag ttggcttatt ggtttcattt aaatgccaga gatttcatta ctgtagagga   5340

aatgtcttat agctcttcta tttaaacttt ggttgggctc ttaattttta aagaggtagg   5400

ataattaaga ctcattatga gtgtgacttt gtaacttgga agtactatct tcacatttca   5460

agatatttaa ggattgcttt agaataaaca aatgtattat gtgaattaat tgattgtacc   5520


<210>  5020
<211>  189
<212>  PRT
<213>  Homosapiens

<400>  5020

Met Ile Val Ser Gly Lys Lys Leu Arg Leu Thr Ile Ile Glu Cys Gly 
1               5                   10                  15      


Cys Asp Ile Asn Met Met Ile Asp Leu Ala Glu Val Ala Asp Leu Val 
            20                  25                  30          


Leu Met Leu Ile Asp Ala Ser Phe Gly Phe Glu Met Glu Thr Phe Glu 
        35                  40                  45              


Phe Leu Asn Ile Cys Gln Val His Gly Phe Pro Lys Ile Met Gly Val 
    50                  55                  60                  


Leu Thr His Leu Asp Phe Phe Lys His Asn Lys Gln Leu Lys Lys Thr 
65                  70                  75                  80  


Lys Lys Arg Leu Lys His Arg Phe Trp Thr Glu Val Tyr Leu Val Ala 
                85                  90                  95      


Lys Leu Phe Cys Leu Ser Gly Met Val His Gly Glu Tyr Gln Asn Gln 
            100                 105                 110         


Glu Met His Asn Leu Gly His Phe Ile Thr Val Met Lys Phe Arg Pro 
        115                 120                 125             


Leu Thr Trp Gln Thr Ser His Pro Tyr Ile Leu Ala Asp Arg Val Glu 
    130                 135                 140                 


Asp Leu Thr Asn Pro Glu Asp Ile Gln Thr Asn Ile Arg Cys Asp Gln 
145                 150                 155                 160 


Gln Met Leu Leu Tyr Gly Tyr Leu Arg Gly Ala His Leu Lys Asn Lys 
                165                 170                 175     


Ser Gln Ile His Met Pro Gly Arg Gly Gly Ala His Pro 
            180                 185                 


<210>  5021
<211>  4120
<212>  DNA
<213>  Homosapiens

<400>  5021
gtggtgtcca atccgacctg aggagtcaca gttgtgagca agttcggtgc cgcgggctgg     60

gattagaatt acttgttatt ggtaaatagc cactatggag actaaggacc agaagaaaca    120

aagaaagaaa aatagtggac ccaaagctgc aaagaaaaag aagcggcatc tgcaggatct    180

ccagctagga gacgaagaag atgcctggaa gagaaatccc aaagcttttg catttcagtc    240

tgctgtgtgg atggctcgat cctttcacag gactcaggat ttgaagacaa aaaagcatca    300

tattccagtg gttgatcgaa ctccactaga gcccccacca atagtggtag tggtgatggg    360

gcctccaaag ttggaaagag cactttgata caatgcctca ttcggaactt cacccggcag    420

aagttgaccg agatcagagg ccctgtgatg atcgtgtcag gtaaaaagct ccgactcacc    480

attattgaat gtgggtgtga cattaacatg atgattgatc tggctgaagt agcagatctg    540

gtactgatgc ttatagatgc cagctttggg tttgaaatgg aaacgtttga gtttctaaac    600

atctgtcaag tacatggctt tcctaaaatt atgggagttc tcacccacct cgacttcttc    660

aaacacaata agcaactgaa gaagacaaag aagcgattaa aacacaggtt ctggacagaa    720

gtttacctgg ttgccaagct gttctgcctt tctggaatgg tgcatggaga atatcaaaac    780

caagaaatgc acaatctggg ccattttatt acagttatga agtttaggcc tctcacatgg    840

cagacttctc atccttatat cctggcagac aggtaaaaag gtggaagatt tgacaaaccc    900

agaggatatc caaacaaaca tcagatgtga ccagcagatg ttactttacg gttatttaag    960

aggagcgcac ttgaaaaata aaagccaaat tcacatgcca ggacgaggtg gggcccaccc   1020

atgagctggt ccagagtctc atctccaccc actccaccat tgatgccaag atggcttcaa   1080

gtcgagtgat gttgttttct gattccaagc cacttgggtc agaggctata gataatcaag   1140

ggtgagtggt gtcattgagc aaacacgaag tcgggctcat ccaaggatga gattttgcca   1200

gagaaaggac gagcagcaag tcagggagct taaggtaatt atgggaaagt gactatctac   1260

aattgcttag gtagaaggag acagattgga tttttgtgtg tttggtattt gggataagag   1320

ggatgtgggt gtgtacttga catgggttgt tctctctctc tctttttttt tttttttttt   1380

ttgagaggga gtctcactct gtcacccagg ctggagttct gtggcacagt cttggctcac   1440

tgcaacctcc gcctgccggg ttcaagggat tctcctgcct cagcctccca agtagctggg   1500

gttacaggtg cctgccacca cgccctgcta atttttgtga tttttttttt agtagagacg   1560

aggtttcact atgtaggcaa agctggtctc gaactcctga cctcagatga tccacccgcc   1620

tcagcctccc aaagtgctgg gattacaggc gtgagccacc gcacctggcc tgtttattct   1680

cttaagagag aaaatgaggg gattaatgga ctgtagttct ggacaaggtg gaaaactctt   1740

aaagtggaag tattggggca agtgctctga caggctagga tggtgcagtc agtcccttca   1800

cccagaaatc agtagaatgt taacagttca gactcaaacc ttgtgaaaaa caggtggtgg   1860

aaaggaaatc cctcacagca actggcacca taatcaagac agaatgtttg cagaataaat   1920

ggagttacct gctttcagcc ccaggttgta gctattgtct gccctgatga tatgtgataa   1980

taatttgtga tcctattgtc ttaaaatggg gtcactcatc tccagtagaa ttaagtccac   2040

agtgaagttg tccccccatc cccaaagaga taaacatata tgaatgaact cacatgataa   2100

caactactgc tgcctgggat catgagagac ctgaactgaa ctgataggaa gtgaaaggtg   2160

gctgagataa tgagaataga cccatctgca gaggatcata aaaccagcaa agacaagatc   2220

ttgtctaaga tgccttcaca aactttgtcc atgagaactc taaggacttc tccagacctg   2280

ttggctgctg ctgtgatctc tgcccaagag gagcctctga ccaacatcca aagggcttct   2340

ggacccactg gactcctctg gaggtacctt ggtctcccga tccatggctg tggtttttta   2400

ctccgtttat cactcctgtg tgtagaatga taattgcaca attgatagtg tgaacacctc   2460

ttgataaatg gtaaatctga gcatatgtat ttggctgaca tgtcattgtg aaacctcaca   2520

gcttcagtca gtgtcagcac agctagggag catgtaccta atgcacatat cactgggcat   2580

agtctacagg cacctaataa ctcaggtacc ttaacagtca ctaatgagtg tctctccaag   2640

gtcaaaacaa tggaagactg tagaagatgc tattcattaa gatatctcaa gaatgtggaa   2700

gactattatt cgcttctcat gggacaggac tttatagggc acctgaaaaa actcccatga   2760

aaaatcactt ttacaaaatg tcaagttatg atatccaaga tgaaaccaat gagtcacaac   2820

attcacataa tacactgtac aaccctgatc tcttgactgt catcaaatgt ttcttacctc   2880

taaaccaaag tttcatttta taatttaatt tttctcattt tttctgttct cttagcttaa   2940

gaaaagatca ttacaaactt tttgtatgtt tttcatatat gcttgcaaag ggttgtaaaa   3000

ctttattgtg attattcttg ctttaagctg aaacttccct aatctttctt tagagattgt   3060

ggcatagcat gttagtttct tttccatatc caattgtttt ctgtaatgaa tacagaaata   3120

tgggcactat tttgtaactt taaatagaca tcatctcaag tctacaagaa ttatccaaaa   3180

tggtatttaa tgacatttct aggtcttcag acactattaa tgtagattgt agcctctagg   3240

tcctgaggat ttttactgga tactggttac tgaaactgag ctttcttgaa ttctttttcc   3300

ttccactgtg gtttcccgca tttcaacaca tcacctattt ttgtcctcaa acgttactta   3360

aattttttcc acagaattaa attaaatatg aatcatccct cctctgattt ttgaaatgac   3420

cctttgcttc ctatgataat gattcttctg gtccgttttg tagttatatg ttagagtttg   3480

taaatattca cacattttgc aactgcatat aattttctca ttttttcctc ttcctctaaa   3540

gctgctgtta tttcttttaa ctttttgtgg gaaaaattaa acccatcttt cactttgttg   3600

atatttataa ttgaactcct tgatttttgc ttgaattgct tttcaagtta cccactttta   3660

gggaagacat tatttgggtt ttgtttagtg tatcaggctt tttttagtta gttgtatcaa   3720

gaagtgtaga cttttctata cataatatcc tttttcccac agtagttttt ttttttttaa   3780

agtctagccg ggtgcagtgg ctcacgcctg taatcccaga ctttgggagg ccgaggtggg   3840

cagatcacga agtcaagaga ccgagaacat cctggctaac acagtgaaac cccgtctcta   3900

ctaaaaatac aaaaaattag ccggacatgg taacgggtgc ctgtagtccc agctaatcag   3960

gaggctgagg caggagaatg acatgaactc aggaggcaga ggttgcagtg agccgagatc   4020

gtgccactgc actccagcct gggtgacaga gcaagactcc atctcaaaaa aaaaaaaaaa   4080

aaaaaagtct gttaaaataa aggtcatcaa aagatctttt                         4120


<210>  5022
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  5022

Met Ile Val Ser Gly Lys Lys Leu Arg Leu Thr Ile Ile Glu Cys Gly 
1               5                   10                  15      


Cys Asp Ile Asn Met Met Ile Asp Leu Ala Glu Val Ala Asp Leu Val 
            20                  25                  30          


Leu Met Leu Ile Asp Ala Ser Phe Gly Phe Glu Met Glu Thr Phe Glu 
        35                  40                  45              


Phe Leu Asn Ile Cys Gln Val His Gly Phe Pro Lys Ile Met Gly Val 
    50                  55                  60                  


Leu Thr His Leu Asp Phe Phe Lys His Asn Lys Gln Leu Lys Lys Thr 
65                  70                  75                  80  


Lys Lys Arg Leu Lys His Arg Phe Trp Thr Glu Val Tyr Leu Val Ala 
                85                  90                  95      


Lys Leu Phe Cys Leu Ser Gly Met Val His Gly Glu Tyr Gln Asn Gln 
            100                 105                 110         


Glu Met His Asn Leu Gly His Phe Ile Thr Val Met Lys Phe Arg Pro 
        115                 120                 125             


Leu Thr Trp Gln Thr Ser His Pro Tyr Ile Leu Ala Asp Arg 
    130                 135                 140         


<210>  5023
<211>  1444
<212>  DNA
<213>  Homosapiens

<400>  5023
atgcggatta aatatccact atccgtgttt ttccgagtct tacagcagaa aggtctgcct     60

gcattttttg gctttgggct cttctccact gtcaccatta gcaaccttgc atcccatgga    120

cctgtcttct atggccacat gtctctgtgg ctctttcctt cccccttctc ttccactgtt    180

aaggactcat gtgcttactt agtcctgaat ggagacaccg tcatcatcca catagcccac    240

tgtcgtaatc catacaggct gctacaagga aatgcattag accaggtagc ttataaacaa    300

tagaactttg tttctcacag tcctggaggc tgagaagtgc aagatcaagg tgccggcagt    360

cttggtgtct ggtgaaggcc tgctttctca tagaggcttc cttcttgctg tgtcttcaca    420

tggggagagg aacaaacaag ctcccttgtg cctttaataa ggtgctaatc ccagtcatga    480

gggcagagtc tcatgtaagg cttaacctcc taatacatca ccttgagggt taggatttta    540

acacatgaac attgacggaa cacaacgttc attccatagc accagggtag tctcctcatg    600

tgaaggtctt tacctgagtc acatgcatga tgtaccattt tcatgtaagg ttctaggaat    660

ctgtggacat ctttgggggg ggccgttatt ttgctgatca catattacat atattttaat    720

attctagact agtatgaaaa caatgccact tccattgctt tatatatgta tatatatata    780

tacacattgt ctaatgctat aattaaaaaa aagttgtaga cacaaatata cccatttaaa    840

aaaaaaccca ttttttgcta ttttacttta tactgccaac tcctttttcc tgaaactgct    900

tcaactctgg aattcttttt tgctgttagt tttattttat tgaaatattc atgaacgagc    960

atacacttgt atatggattt aaaattcaca gtaaagttct catgaattca tctgtgaata   1020

acattttata gacaaaatgt ctgcactagg acaagagaaa gatgtataat tcccttgttc   1080

taaggtaccg ccattcattg ttattatttt aaaatacgag tgttgactga tgttaaaaca   1140

caaaatgggg ccgggagtgg tggctcccgc ctgtaatccc aacactttgg gagatcgagg   1200

tgggtggatc acctgaggtc aggagtttga gaccagcttg gccaacatgg tgaaaccccg   1260

tctctactaa aaatacaaaa attagctggg catgtgttgc acgcccgtaa tcttagctac   1320

ccgggaaact gagtcaggag aattgctgga acctgggagg cggaggctgc agtgagccga   1380

gatcacacca gtgcactcca gcctgggtga cagagcgaga ctctgttctt ccccccaccc   1440

ccaa                                                                1444


<210>  5024
<211>  100
<212>  PRT
<213>  Homosapiens

<400>  5024

Met Arg Ile Lys Tyr Pro Leu Ser Val Phe Phe Arg Val Leu Gln Gln 
1               5                   10                  15      


Lys Gly Leu Pro Ala Phe Phe Gly Phe Gly Leu Phe Ser Thr Val Thr 
            20                  25                  30          


Ile Ser Asn Leu Ala Ser His Gly Pro Val Phe Tyr Gly His Met Ser 
        35                  40                  45              


Leu Trp Leu Phe Pro Ser Pro Phe Ser Ser Thr Val Lys Asp Ser Cys 
    50                  55                  60                  


Ala Tyr Leu Val Leu Asn Gly Asp Thr Val Ile Ile His Ile Ala His 
65                  70                  75                  80  


Cys Arg Asn Pro Tyr Arg Leu Leu Gln Gly Asn Ala Leu Asp Gln Val 
                85                  90                  95      


Ala Tyr Lys Gln 
            100 


<210>  5025
<211>  1414
<212>  DNA
<213>  Homosapiens

<400>  5025
atggcttcaa gtcgagtgat gttgttttct gattccaagc cacttgggtc agaggctata     60

gataatcaag gcaaccttgc atcccatgga cctgtcttct atggccacat gtctctgtgg    120

ctctttcctt cccccttctc ttccactgtt aaggactcat gtgcttactt agtcctgaat    180

ggagacaccg tcatcatcca catagcccac tgtcgtaatc catacaggct gctacaagga    240

aatgcattag accaggtagc ttataaacaa tagaactttg tttctcacag tcctggaggc    300

tgagaagtgc aagatcaagg tgccggcagt cttggtgtct ggtgaaggcc tgctttctca    360

tagaggcttc cttcttgctg tgtcttcaca tggggagagg aacaaacaag ctcccttgtg    420

cctttaataa ggtgctaatc ccagtcatga gggcagagtc tcatgtaagg cttaacctcc    480

taatacatca ccttgagggt taggatttta acacatgaac attgacggaa cacaacgttc    540

attccatagc accagggtag tctcctcatg tgaaggtctt tacctgagtc acatgcatga    600

tgtaccattt tcatgtaagg ttctaggaat ctgtggacat ctttgggggg cgccgttatt    660

ttgctgatca catattacat atattttaat attctagact agtatgaaaa caatgccact    720

tccattgctt tatatatgta tatatatata tacacattgt ctaatgctat aattaaaaaa    780

aagttgtaga cacaaatata cccatttaaa aaaaaaccca ttttttgcta ttttacttta    840

tactgccaac tcctttttcc tgaaactgct tcaactctgg aattcttttt tgctgttagt    900

tttattttat tgaaatattc atgaacgagc atacacttgt atatggattt aaaattcaca    960

gtaaagttct catgaattca tctgtgaata acattttata gacaaaatgt ctgcactagg   1020

acaagagaaa gatgtataat tcccttgttc taaggtaccg ccattcattg ttattatttt   1080

aaaatacgag tgttgactga tgttaaaaca caaaatgggg ccgggagtgg tggctcccgc   1140

ctgtaatccc aacactttgg gagatcgagg tgggtggatc acctgaggtc aggagtttga   1200

gaccagcttg gccaacatgg tgaaaccccg tctctactaa aaatacaaaa attagctggg   1260

catgtgttgc acgcccgtaa tcttagctac ccgggaaact gagtcaggag aattgctgga   1320

acctgggagg cggaggctgc agtgagccga gatcacacca gtgcactcca gcctgggtga   1380

cagagcgaga ctctgttctt ccccccaccc ccca                               1414


<210>  5026
<211>  90
<212>  PRT
<213>  Homosapiens

<400>  5026

Met Ala Ser Ser Arg Val Met Leu Phe Ser Asp Ser Lys Pro Leu Gly 
1               5                   10                  15      


Ser Glu Ala Ile Asp Asn Gln Gly Asn Leu Ala Ser His Gly Pro Val 
            20                  25                  30          


Phe Tyr Gly His Met Ser Leu Trp Leu Phe Pro Ser Pro Phe Ser Ser 
        35                  40                  45              


Thr Val Lys Asp Ser Cys Ala Tyr Leu Val Leu Asn Gly Asp Thr Val 
    50                  55                  60                  


Ile Ile His Ile Ala His Cys Arg Asn Pro Tyr Arg Leu Leu Gln Gly 
65                  70                  75                  80  


Asn Ala Leu Asp Gln Val Ala Tyr Lys Gln 
                85                  90  


<210>  5027
<211>  2356
<212>  DNA
<213>  Homosapiens

<400>  5027
tccaatatgg ctgagatcct tatcaaaagg agaaattcag tcacagggac agacaggtac     60

agagagaaga tgatgtcaag agacaacggg agaatgccac atgaaggtgg aggattggag    120

taatgcatct acaagccaag aaaaccttgt tgggagtttg attagacggc tgagaaagac    180

agcaaatcta cagggtttgt caaagataag atcgttgtca tggcatgaaa aggatgacct    240

ttccagtctg caatacctgc ttgaccacta agaccaaaca gctcaaatta aaggtaacaa    300

attccgcaga ggcaattgtt caacacagga aaaagaaacc actttaagga ttttaaactg    360

gaagagattt tacataagct gttttaaaca aaaccattgg atgacctgga gtaacagtgt    420

cggaaactca gctgagctgg atagagaact gagctgcccg ttgttggaga agttgattaa    480

agcagcagcc gaagatcgaa gtaacagtca agactgtaat cacttactgc aatagtataa    540

gcaagaggcc aaaaccaaag aaactgccaa ctcacccagg tcttctaaat tccccagaaa    600

ggtgcactag tggagggtca gtgaatcagg acagacatgg gggtcagctc acgattgagg    660

aagccccaaa caaaaatctc cagtagtatt atgaaccctg gagcaggagg ttggagtgag    720

acaaggagag ctaggagtag aagagtatgg agtcggagga gggaacggtt tcttaaggtc    780

tcctcccact ctactcttaa gaaagcttca gtagaagcac ctgaagaaaa ctccagcagg    840

aagccctcag ataaagaaac ttctgaatga agacacctag gctaggaatg caaatatgtt    900

taagagcatg ggccattagg ggaatctgag ttccagaatg caattctctt taaagattgc    960

aatgcactgg gtatgcccca agtctgggga gggcaacttt cctcggaggg gtttgccaga   1020

taaagccttt gtcattgcct gtggttgggc ctgaaatatc aaacatagat ttttggccag   1080

gactcctcag caggatctag tcagggcctt cacaaagtac attcagaatg acaattgacc   1140

caccagaaag ccatcatgcc accacttgat attttaaatg aaaagaccca ccaacatatc   1200

tgatatccat atctgatacc cagtagaatt ggaatgctgc tatcaccact gtcactattg   1260

tcactaccac acctgcctct agaaacccag caatctggag gatggaccct ggataatgtt   1320

gcaggcaaac ctcatttctc tacaactgtg ctttccacca acagtcgatt aaaggaagac   1380

gaagatcgag tgtgtgtgga tgatacagca aataaacctt cttctagttc ttaaagatta   1440

tggttttcag tgtttagtga gcatccgtgt tcatctttaa aggatagaaa aatgcaggag   1500

gcatcttgta tccatgaaga tactaaaaca cggatttcct caggaaattg atcactcaag   1560

catccataat cttagtagac tgcccttata gtcgtattgc agaatgtgtg atctgccatc   1620

tactgagggc tcatttttcc ctctcctctc tcatccaaga ttggtgatag tttcaaattt   1680

ttctcccact attatgtaga ataatttcca aacttgacac tcaattgaat catggtgtcc   1740

aggaaaatag ataaaataaa tatgacttca tataccagaa gtcatattcc tttgaataca   1800

atcagggcca taaatggcac ttgcttctat aacacaaagt gctattataa ttatatacat   1860

gattttttaa ataattaagt aacttggaac cagtttctat tgcaataatt ataagaaaca   1920

aagacctcca actgaatgaa cccctctgaa atattttaat aaactctgag gagtactatt   1980

tgtcaagcaa agaaatactg aattaaggta aatgccagct taggatgaaa agaacagcaa   2040

cagtgcctac cttcattacc tcagcctctc cctggctaag ataatcactt aatcttttat   2100

gcctttgcta aaacctcatt agtaaaaagg agacctgcct actaagcata aggttaaggc   2160

tttaatggac tttagaaatc atttactttt atgactcaaa gcactgaagt gcaaattctt   2220

tttatttgaa tatttgaggg cattaaatga gcatttttaa tggatttcaa ttgtcaggat   2280

aaaataaaat ttctcaaggg gaatctgaat tttaacaaac attaaaatca aagaagtaaa   2340

aagatgaata aatgga                                                   2356


<210>  5028
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  5028

Met Lys Val Glu Asp Trp Ser Asn Ala Ser Thr Ser Gln Glu Asn Leu 
1               5                   10                  15      


Val Gly Ser Leu Ile Arg Arg Leu Arg Lys Thr Ala Asn Leu Gln Gly 
            20                  25                  30          


Leu Ser Lys Ile Arg Ser Leu Ser Trp His Glu Lys Asp Asp Leu Ser 
        35                  40                  45              


Ser Leu Gln Tyr Leu Leu Asp His 
    50                  55      


<210>  5029
<211>  2356
<212>  DNA
<213>  Homosapiens

<400>  5029
tccaatatgg ctgagatcct tatcaaaagg agaaattcag tcacagggac agacaggtac     60

agagagaaga tgatgtcaag agacaacggg agaatgccac atgaaggtgg aggattggag    120

taatgcatct acaagccaag aaaaccttgt tgggagtttg attagacggc tgagaaagac    180

agcaaatcta cagggtttgt caaagataag atcgttgtca tggcatgaaa aggatgacct    240

ttccagtctg caatacctgc ttgaccacta agaccaaaca gctcaaatta aaggtaacaa    300

attccgcaga ggcaattgtt caacacagga aaaagaaacc actttaagga ttttaaactg    360

gaagagattt tacataagct gttttaaaca aaaccattgg atgacctgga gtaacagtgt    420

cggaaactca gctgagctgg atagagaact gagctgcccg ttgttggaga agttgattaa    480

agcagcagcc gaagatcgaa gtaacagtca agactgtaat cacttactgc aatagtataa    540

gcaagaggcc aaaaccaaag aaactgccaa ctcacccagg tcttctaaat tccccagaaa    600

ggtgcactag tggagggtca gtgaatcagg acagacatgg gggtcagctc acgattgagg    660

aagccccaaa caaaaatctc cagtagtatt atgaaccctg gagcaggagg ttggagtgag    720

acaaggagag ctaggagtag aagagtatgg agtcggagga gggaacggtt tcttaaggtc    780

tcctcccact ctactcttaa gaaagcttca gtagaagcac ctgaagaaaa ctccagcagg    840

aagccctcag ataaagaaac ttctgaatga agacacctag gctaggaatg caaatatgtt    900

taagagcatg ggccattagg ggaatctgag ttccagaatg caattctctt taaagattgc    960

aatgcactgg gtatgcccca agtctgggga gggcaacttt cctcggaggg gtttgccaga   1020

taaagccttt gtcattgcct gtggttgggc ctgaaatatc aaacatagat ttttggccag   1080

gactcctcag caggatctag tcagggcctt cacaaagtac attcagaatg acaattgacc   1140

caccagaaag ccatcatgcc accacttgat attttaaatg aaaagaccca ccaacatatc   1200

tgatatccat atctgatacc cagtagaatt ggaatgctgc tatcaccact gtcactattg   1260

tcactaccac acctgcctct agaaacccag caatctggag gatggaccct ggataatgtt   1320

gcaggcaaac ctcatttctc tacaactgtg ctttccacca acagtcgatt aaaggaagac   1380

gaagatcgag tgtgtgtgga tgatacagca aataaacctt cttctagttc ttaaagatta   1440

tggttttcag tgtttagtga gcatccgtgt tcatctttaa aggatagaaa aatgcaggag   1500

gcatcttgta tccatgaaga tactaaaaca cggatttcct caggaaattg atcactcaag   1560

catccataat cttagtagac tgcccttata gtcgtattgc agaatgtgtg atctgccatc   1620

tactgagggc tcatttttcc ctctcctctc tcatccaaga ttggtgatag tttcaaattt   1680

ttctcccact attatgtaga ataatttcca aacttgacac tcaattgaat catggtgtcc   1740

aggaaaatag ataaaataaa tatgacttca tataccagaa gtcatattcc tttgaataca   1800

atcagggcca taaatggcac ttgcttctat aacacaaagt gctattataa ttatatacat   1860

gattttttaa ataattaagt aacttggaac cagtttctat tgcaataatt ataagaaaca   1920

aagacctcca actgaatgaa cccctctgaa atattttaat aaactctgag gagtactatt   1980

tgtcaagcaa agaaatactg aattaaggta aatgccagct taggatgaaa agaacagcaa   2040

cagtgcctac cttcattacc tcagcctctc cctggctaag ataatcactt aatcttttat   2100

gcctttgcta aaacctcatt agtaaaaagg agacctgcct actaagcata aggttaaggc   2160

tttaatggac tttagaaatc atttactttt atgactcaaa gcactgaagt gcaaattctt   2220

tttatttgaa tatttgaggg cattaaatga gcatttttaa tggatttcaa ttgtcaggat   2280

aaaataaaat ttctcaaggg gaatctgaat tttaacaaac attaaaatca aagaagtaaa   2340

aagatgaata aatgga                                                   2356


<210>  5030
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  5030

Met Lys Val Glu Asp Trp Ser Asn Ala Ser Thr Ser Gln Glu Asn Leu 
1               5                   10                  15      


Val Gly Ser Leu Ile Arg Arg Leu Arg Lys Thr Ala Asn Leu Gln Gly 
            20                  25                  30          


Leu Ser Lys Ile Arg Ser Leu Ser Trp His Glu Lys Asp Asp Leu Ser 
        35                  40                  45              


Ser Leu Gln Tyr Leu Leu Asp His 
    50                  55      


<210>  5031
<211>  633
<212>  DNA
<213>  Homosapiens

<400>  5031
atggactcac gaattgttat attcaaagtg gagggcgtca atcaagaaaa tgcccccttg     60

ccccggaggc gagtggagcc gcacagagcc gaggccatac gggccagcag tacggactgc    120

ttcaatagaa aacacgtgca aaaccagaga gccagactgc gcacagctgc gaccctcaag    180

agccagcaga aaagacacgg agcggccccc actggattga agactgcaca gcctctgccc    240

ggcgctgtag gacccgggcc tccccttgat tgctgctcgc agcggcttct gccagcatcc    300

tcgcggaagt ggcttgagga gcgcacccac cgaggaggcg tcttaggcca gcggcctctg    360

ctcccgccga gtcccgctgc tccccgcctg gaaacagctg ctgccacccc gggcccaggc    420

ctggacggcg cccccgaatt tcggcagagg tgcctcgggg ccgcggacag ggccgctgga    480

gcccgcactc cagaaggcgg tcttcctcgc gcctcccccg acggacgcgg cccagggctt    540

ccctcgaggg cgtcctcggc cggggtgcct ggagtcccca ggggcgacag ccgcggcggg    600

gcaccagggc gccagttccc cggagcctgg tag                                 633


<210>  5032
<211>  210
<212>  PRT
<213>  Homosapiens

<400>  5032

Met Asp Ser Arg Ile Val Ile Phe Lys Val Glu Gly Val Asn Gln Glu 
1               5                   10                  15      


Asn Ala Pro Leu Pro Arg Arg Arg Val Glu Pro His Arg Ala Glu Ala 
            20                  25                  30          


Ile Arg Ala Ser Ser Thr Asp Cys Phe Asn Arg Lys His Val Gln Asn 
        35                  40                  45              


Gln Arg Ala Arg Leu Arg Thr Ala Ala Thr Leu Lys Ser Gln Gln Lys 
    50                  55                  60                  


Arg His Gly Ala Ala Pro Thr Gly Leu Lys Thr Ala Gln Pro Leu Pro 
65                  70                  75                  80  


Gly Ala Val Gly Pro Gly Pro Pro Leu Asp Cys Cys Ser Gln Arg Leu 
                85                  90                  95      


Leu Pro Ala Ser Ser Arg Lys Trp Leu Glu Glu Arg Thr His Arg Gly 
            100                 105                 110         


Gly Val Leu Gly Gln Arg Pro Leu Leu Pro Pro Ser Pro Ala Ala Pro 
        115                 120                 125             


Arg Leu Glu Thr Ala Ala Ala Thr Pro Gly Pro Gly Leu Asp Gly Ala 
    130                 135                 140                 


Pro Glu Phe Arg Gln Arg Cys Leu Gly Ala Ala Asp Arg Ala Ala Gly 
145                 150                 155                 160 


Ala Arg Thr Pro Glu Gly Gly Leu Pro Arg Ala Ser Pro Asp Gly Arg 
                165                 170                 175     


Gly Pro Gly Leu Pro Ser Arg Ala Ser Ser Ala Gly Val Pro Gly Val 
            180                 185                 190         


Pro Arg Gly Asp Ser Arg Gly Gly Ala Pro Gly Arg Gln Phe Pro Gly 
        195                 200                 205             


Ala Trp 
    210 


<210>  5033
<211>  981
<212>  DNA
<213>  Homosapiens

<400>  5033
atgactaagg acgtcagcaa ctggacctca ccagctgacg tggccggccc tggacttgcc     60

atggagaagg cagagcctgc ctcccagtgg gtccctagtg accgtcccta tcactggagc    120

cgatcccaga gtgaccgtcc ctatcactgg cgccgatccc agagtgaccg tccctatcac    180

tggagccgat cccagagtga ccgtccctat cactggcgcc gatcccagag tgaccgtccc    240

tatcactggc gccgatccca gagtgaccgt ccctatcact ggcgccgatc ccagagtgac    300

cgtccctatc actggcgccg atcccagagt gaccgtccct atcactggcg ccgatcccag    360

agtgaccgtc cctatcactg gcgccgatcc cagagtgacc gtccctatca ctggcgccga    420

tcccagagtg accgtcccta tcactggcgc cgatcccaga gtgaccgtcc ctatcactgg    480

cgccgatccc agagtgaccg tccctatcac tggcgccgat cccagagtga ccgtccctat    540

cactggagcc gatcccagag tgaccgtccc tatcactgga gccgatccca gagtgaccgt    600

ccctatcact ggcgccgatc ccagagtgac cgtccctatc actggagccg atcccagagt    660

gaccgtccct atcactggag ccgatcccag agtgaccgtc cctatcactg gcgccgatcc    720

cagagtgacc gtccctatca ctggagccga tcccagagtg accgtcccta tcactggagc    780

cgatcccaga gtgaccgtcc ctatcactgg agccgatccc agagtgaccg tccctatcac    840

tggcgccgat cccagagtga ccgtccctat cactggagcc gatcccagag tgaccgtccc    900

tatcactgga gccgatccca gagtgaccgt ccctatcact ggcgccgatc ccagagtgac    960

cgtccctatc actggagctg a                                              981


<210>  5034
<211>  326
<212>  PRT
<213>  Homosapiens

<400>  5034

Met Thr Lys Asp Val Ser Asn Trp Thr Ser Pro Ala Asp Val Ala Gly 
1               5                   10                  15      


Pro Gly Leu Ala Met Glu Lys Ala Glu Pro Ala Ser Gln Trp Val Pro 
            20                  25                  30          


Ser Asp Arg Pro Tyr His Trp Ser Arg Ser Gln Ser Asp Arg Pro Tyr 
        35                  40                  45              


His Trp Arg Arg Ser Gln Ser Asp Arg Pro Tyr His Trp Ser Arg Ser 
    50                  55                  60                  


Gln Ser Asp Arg Pro Tyr His Trp Arg Arg Ser Gln Ser Asp Arg Pro 
65                  70                  75                  80  


Tyr His Trp Arg Arg Ser Gln Ser Asp Arg Pro Tyr His Trp Arg Arg 
                85                  90                  95      


Ser Gln Ser Asp Arg Pro Tyr His Trp Arg Arg Ser Gln Ser Asp Arg 
            100                 105                 110         


Pro Tyr His Trp Arg Arg Ser Gln Ser Asp Arg Pro Tyr His Trp Arg 
        115                 120                 125             


Arg Ser Gln Ser Asp Arg Pro Tyr His Trp Arg Arg Ser Gln Ser Asp 
    130                 135                 140                 


Arg Pro Tyr His Trp Arg Arg Ser Gln Ser Asp Arg Pro Tyr His Trp 
145                 150                 155                 160 


Arg Arg Ser Gln Ser Asp Arg Pro Tyr His Trp Arg Arg Ser Gln Ser 
                165                 170                 175     


Asp Arg Pro Tyr His Trp Ser Arg Ser Gln Ser Asp Arg Pro Tyr His 
            180                 185                 190         


Trp Ser Arg Ser Gln Ser Asp Arg Pro Tyr His Trp Arg Arg Ser Gln 
        195                 200                 205             


Ser Asp Arg Pro Tyr His Trp Ser Arg Ser Gln Ser Asp Arg Pro Tyr 
    210                 215                 220                 


His Trp Ser Arg Ser Gln Ser Asp Arg Pro Tyr His Trp Arg Arg Ser 
225                 230                 235                 240 


Gln Ser Asp Arg Pro Tyr His Trp Ser Arg Ser Gln Ser Asp Arg Pro 
                245                 250                 255     


Tyr His Trp Ser Arg Ser Gln Ser Asp Arg Pro Tyr His Trp Ser Arg 
            260                 265                 270         


Ser Gln Ser Asp Arg Pro Tyr His Trp Arg Arg Ser Gln Ser Asp Arg 
        275                 280                 285             


Pro Tyr His Trp Ser Arg Ser Gln Ser Asp Arg Pro Tyr His Trp Ser 
    290                 295                 300                 


Arg Ser Gln Ser Asp Arg Pro Tyr His Trp Arg Arg Ser Gln Ser Asp 
305                 310                 315                 320 


Arg Pro Tyr His Trp Ser 
                325     


<210>  5035
<211>  358
<212>  DNA
<213>  Homosapiens

<400>  5035
atgtgcagac cacaggaata cctaatgcct tttttctctt cctgtctttg tccctcacac     60

tacagcaggc ccctcccttc cctcttcaac ctcatcctcc ctccccacag gcccagagaa    120

ccagttgggc tttgttctcc tgcaggctat ggttcatcat gcaaatagct cctgtgtcag    180

aaatgctttt tggcttcaaa taacagaaaa gctaacacca gctttatcaa taataatatc    240

ggtggtttac ttaaggtgtc cagagatggt ggagaacagg attggtttcc tcctcaatgt    300

caaggactca aagactcttt ctgtggtagg gccacatcct aaaccctgta tcctgtga      358


<210>  5036
<211>  119
<212>  PRT
<213>  Homosapiens


<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa can be any naturally occurring amino acid

<400>  5036

Met Cys Arg Pro Gln Glu Tyr Leu Met Pro Phe Phe Ser Ser Cys Leu 
1               5                   10                  15      


Cys Pro Ser His Tyr Ser Arg Pro Leu Pro Ser Leu Phe Asn Leu Ile 
            20                  25                  30          


Leu Pro Pro His Arg Pro Arg Glu Pro Val Gly Leu Cys Ser Pro Ala 
        35                  40                  45              


Gly Tyr Gly Ser Ser Cys Lys Xaa Leu Leu Cys Gln Lys Cys Phe Leu 
    50                  55                  60                  


Ala Ser Asn Asn Arg Lys Ala Asn Thr Ser Phe Ile Asn Asn Asn Ile 
65                  70                  75                  80  


Gly Gly Leu Leu Lys Val Ser Arg Asp Gly Gly Glu Gln Asp Trp Phe 
                85                  90                  95      


Pro Pro Gln Cys Gln Gly Leu Lys Asp Ser Phe Cys Gly Arg Ala Thr 
            100                 105                 110         


Ser Xaa Thr Leu Tyr Pro Val 
        115                 


<210>  5037
<211>  328
<212>  DNA
<213>  Homosapiens

<400>  5037
agggcaaaag agattttgca gatgcaatta aggttaagga ccttgacgtg ggaagattgt     60

gattatttac ctgacagggc aaaagagatt ttgcagatgc aattaaggtt aaggaccttg    120

acgtgggaag attattctgg attatctagg tgggcgcaat ttgatcacat gggtccccag    180

aagtggagaa cctttcccac ctgtagaaag ccagagagct ggcacctgag aaggacagaa    240

ctgtcattgc aggatttgaa gatgaagggg cccatgagcc aaggaatgcc agtgacctat    300

agaggctaaa aaacagcaag gaaatgga                                       328


<210>  5038
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  5038

Met Gln Leu Arg Leu Arg Thr Leu Thr Trp Glu Asp Cys Asp Tyr Leu 
1               5                   10                  15      


Pro Asp Arg Ala Lys Glu Ile Leu Gln Met Gln Leu Arg Leu Arg Thr 
            20                  25                  30          


Leu Thr Trp Glu Asp Tyr Ser Gly Leu Ser Arg Trp Ala Gln Phe Asp 
        35                  40                  45              


His Met Gly Pro Gln Lys Trp Arg Thr Phe Pro Thr Cys Arg Lys Pro 
    50                  55                  60                  


Glu Ser Trp His Leu Arg Arg Thr Glu Leu Ser Leu Gln Asp Leu Lys 
65                  70                  75                  80  


Met Lys Gly Pro Met Ser Gln Gly Met Pro Val Thr Tyr Arg Gly 
                85                  90                  95  


<210>  5039
<211>  837
<212>  DNA
<213>  Homosapiens

<400>  5039
atggaactga aactggaggc agaaggtgga gagcattatg acatttttct tttgatttac     60

cgcttttgta agaagtggcg catataccca gagaagtatg aagataagag ccattgcagt    120

acattgagct ccatagagac agcaccgggg aaagtgagag tttcagtcaa cttctcagag    180

ttttctaaga agtgctcaga gaggtggaag aacatgtctg ctaaagagaa aggaaaattt    240

ggccgggcgc gaggaaaatt tgaagatatg gcaaaggcgg acaaggccca ttataagaga    300

gaaatgaaaa cctatatccc tcccaaaggg gagacaaaaa agaagttcaa ggatcccaat    360

gcgcccaaga ggcctccttc agccttcttc ctgtacttct ctgagtatgg cccaaaaatc    420

aaaggagaac gtcctggcct gtcctttggt gatgttgcga agaagctggg agagatgtgg    480

aataacactg ctgcagatga caagcagcct tatgaaaaga ggtcggcgaa gctgaaagaa    540

aaatacgaaa aggatattgc tgcatatcga gctaaaggaa agcatgatgc tgcaaacaat    600

ggagttgtca aggctgcaaa aaattttaga gtatcctatt tgtttgaaga gacacctgga    660

agtttaactt catttttcgg aggaaaattc agtagtcaag aaagaatgtt gctgaaatat    720

aatactcgtg atcaaaaggt ggactattac caaaagagaa ttggaaagaa actactacag    780

aatttaaata tgccagcctt ctaccactct ttgcctgagc tttgcaaggc agggtaa       837


<210>  5040
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  5040

Met Glu Leu Lys Leu Glu Ala Glu Gly Gly Glu His Tyr Asp Ile Phe 
1               5                   10                  15      


Leu Leu Ile Tyr Arg Phe Cys Lys Lys Trp Arg Ile Tyr Pro Glu Lys 
            20                  25                  30          


Tyr Glu Asp Lys Ser His Cys Ser Thr Leu Ser Ser Ile Glu Thr Ala 
        35                  40                  45              


Pro Gly Lys Val Arg Val Ser Val Asn Phe Ser Glu Phe Ser Lys Lys 
    50                  55                  60                  


Cys Ser Glu Arg Trp Lys Asn Met Ser Ala Lys Glu Lys Gly Lys Phe 
65                  70                  75                  80  


Gly Arg Ala Arg Gly Lys Phe Glu Asp Met Ala Lys Ala Asp Lys Ala 
                85                  90                  95      


His Tyr Lys Arg Glu Met Lys Thr Tyr Ile Pro Pro Lys Gly Glu Thr 
            100                 105                 110         


Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser Ala 
        115                 120                 125             


Phe Phe Leu Tyr Phe Ser Glu Tyr Gly Pro Lys Ile Lys Gly Glu Arg 
    130                 135                 140                 


Pro Gly Leu Ser Phe Gly Asp Val Ala Lys Lys Leu Gly Glu Met Trp 
145                 150                 155                 160 


Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu Lys Arg Ser Ala 
                165                 170                 175     


Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala Tyr Arg Ala Lys 
            180                 185                 190         


Gly Lys His Asp Ala Ala Asn Asn Gly Val Val Lys Ala Ala Lys Asn 
        195                 200                 205             


Phe Arg Val Ser Tyr Leu Phe Glu Glu Thr Pro Gly Ser Leu Thr Ser 
    210                 215                 220                 


Phe Phe Gly Gly Lys Phe Ser Ser Gln Glu Arg Met Leu Leu Lys Tyr 
225                 230                 235                 240 


Asn Thr Arg Asp Gln Lys Val Asp Tyr Tyr Gln Lys Arg Ile Gly Lys 
                245                 250                 255     


Lys Leu Leu Gln Asn Leu Asn Met Pro Ala Phe Tyr His Ser Leu Pro 
            260                 265                 270         


Glu Leu Cys Lys Ala Gly 
        275             


<210>  5041
<211>  837
<212>  DNA
<213>  Homosapiens

<400>  5041
atggaactga aactggaggc agaaggtgga gagcattatg acatttttct tttgatttac     60

cgcttttgta agaagtggcg catataccca gagaagtatg aagataagag ccattgcagt    120

acattgagct ccatagagac agcaccgggg aaagtgagag tttcagtcaa cttctcagag    180

ttttctaaga agtgctcaga gaggtggaag aacatgtctg ctaaagagaa aggaaaattt    240

ggccgggcgc gaggaaaatt tgaagatatg gcaaaggcgg acaaggccca ttataagaga    300

gaaatgaaaa cctatatccc tcccaaaggg gagacaaaaa agaagttcaa ggatcccaat    360

gcgcccaaga ggcctccttc agccttcttc ctgtacttct ctgagtatgg cccaaaaatc    420

aaaggagaac gtcctggcct gtcctttggt gatgttgcga agaagctggg agagatgtgg    480

aataacactg ctgcagatga caagcagcct tatgaaaaga ggtcggcgaa gctgaaagaa    540

aaatacgaaa aggatattgc tgcatatcga gctaaaggaa agcatgatgc tgcaaacaat    600

ggagttgtca aggctgcaaa aaattttaga gtatcctatt tgtttgaaga gacacctgga    660

agtttaactt catttttcgg aggaaaattc agtagtcaag aaagaatgtt gctgaaatat    720

aatactcgtg atcaaaaggt ggactattac caaaagagaa ttggaaagaa actactacag    780

aatttaaata tgccagcctt ctaccactct ttgcctgagc tttgcaaggc agggtaa       837


<210>  5042
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  5042

Met Glu Leu Lys Leu Glu Ala Glu Gly Gly Glu His Tyr Asp Ile Phe 
1               5                   10                  15      


Leu Leu Ile Tyr Arg Phe Cys Lys Lys Trp Arg Ile Tyr Pro Glu Lys 
            20                  25                  30          


Tyr Glu Asp Lys Ser His Cys Ser Thr Leu Ser Ser Ile Glu Thr Ala 
        35                  40                  45              


Pro Gly Lys Val Arg Val Ser Val Asn Phe Ser Glu Phe Ser Lys Lys 
    50                  55                  60                  


Cys Ser Glu Arg Trp Lys Asn Met Ser Ala Lys Glu Lys Gly Lys Phe 
65                  70                  75                  80  


Gly Arg Ala Arg Gly Lys Phe Glu Asp Met Ala Lys Ala Asp Lys Ala 
                85                  90                  95      


His Tyr Lys Arg Glu Met Lys Thr Tyr Ile Pro Pro Lys Gly Glu Thr 
            100                 105                 110         


Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser Ala 
        115                 120                 125             


Phe Phe Leu Tyr Phe Ser Glu Tyr Gly Pro Lys Ile Lys Gly Glu Arg 
    130                 135                 140                 


Pro Gly Leu Ser Phe Gly Asp Val Ala Lys Lys Leu Gly Glu Met Trp 
145                 150                 155                 160 


Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu Lys Arg Ser Ala 
                165                 170                 175     


Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala Tyr Arg Ala Lys 
            180                 185                 190         


Gly Lys His Asp Ala Ala Asn Asn Gly Val Val Lys Ala Ala Lys Asn 
        195                 200                 205             


Phe Arg Val Ser Tyr Leu Phe Glu Glu Thr Pro Gly Ser Leu Thr Ser 
    210                 215                 220                 


Phe Phe Gly Gly Lys Phe Ser Ser Gln Glu Arg Met Leu Leu Lys Tyr 
225                 230                 235                 240 


Asn Thr Arg Asp Gln Lys Val Asp Tyr Tyr Gln Lys Arg Ile Gly Lys 
                245                 250                 255     


Lys Leu Leu Gln Asn Leu Asn Met Pro Ala Phe Tyr His Ser Leu Pro 
            260                 265                 270         


Glu Leu Cys Lys Ala Gly 
        275             


<210>  5043
<211>  522
<212>  DNA
<213>  Homosapiens

<400>  5043
atgggcagtt atgtgggact gttccccacc acccttgcca gggccccaag tttctgccga     60

atatggattc ccaggtacga tgaaatagcc agaccattat acacactaat taaggaaact    120

cagaaagcca atactcattt agtaaaatgg acacctgaag cagaagtggc tttccaggcc    180

ctaaagaagg ccgtaaccca agccccagtg ttaagcttgc caacaggaca agacttttct    240

ttatatgtca cagaaaaaac aggaatagct ctaggagtcc ttacacagat ccgagggatg    300

agcttgcaat cagtggcata cctaagtaag gaaattgatg tagtggcaaa gggttggcct    360

ctttgtctac aggtagtggt ggcagtagca gtcttagtat ctgaagcagt taaaataata    420

cagggaagag atcttactgt gtggacatct catgatgtga atggcatatt cactgctaaa    480

ggagacttgt ggctgtcaga gaactgtgag gaaagtaact aa                       522


<210>  5044
<211>  173
<212>  PRT
<213>  Homosapiens

<400>  5044

Met Gly Ser Tyr Val Gly Leu Phe Pro Thr Thr Leu Ala Arg Ala Pro 
1               5                   10                  15      


Ser Phe Cys Arg Ile Trp Ile Pro Arg Tyr Asp Glu Ile Ala Arg Pro 
            20                  25                  30          


Leu Tyr Thr Leu Ile Lys Glu Thr Gln Lys Ala Asn Thr His Leu Val 
        35                  40                  45              


Lys Trp Thr Pro Glu Ala Glu Val Ala Phe Gln Ala Leu Lys Lys Ala 
    50                  55                  60                  


Val Thr Gln Ala Pro Val Leu Ser Leu Pro Thr Gly Gln Asp Phe Ser 
65                  70                  75                  80  


Leu Tyr Val Thr Glu Lys Thr Gly Ile Ala Leu Gly Val Leu Thr Gln 
                85                  90                  95      


Ile Arg Gly Met Ser Leu Gln Ser Val Ala Tyr Leu Ser Lys Glu Ile 
            100                 105                 110         


Asp Val Val Ala Lys Gly Trp Pro Leu Cys Leu Gln Val Val Val Ala 
        115                 120                 125             


Val Ala Val Leu Val Ser Glu Ala Val Lys Ile Ile Gln Gly Arg Asp 
    130                 135                 140                 


Leu Thr Val Trp Thr Ser His Asp Val Asn Gly Ile Phe Thr Ala Lys 
145                 150                 155                 160 


Gly Asp Leu Trp Leu Ser Glu Asn Cys Glu Glu Ser Asn 
                165                 170             


<210>  5045
<211>  522
<212>  DNA
<213>  Homosapiens

<400>  5045
atgggcagtt atgtgggact gttccccacc acccttgcca gggccccaag tttctgccga     60

atatggattc ccaggtacga tgaaatagcc agaccattat acacactaat taaggaaact    120

cagaaagcca atactcattt agtaaaatgg acacctgaag cagaagtggc tttccaggcc    180

ctaaagaagg ccgtaaccca agccccagtg ttaagcttgc caacaggaca agacttttct    240

ttatatgtca cagaaaaaac aggaatagct ctaggagtcc ttacacagat ccgagggatg    300

agcttgcaat cagtggcata cctaagtaag gaaattgatg tagtggcaaa gggttggcct    360

ctttgtctac aggtagtggt ggcagtagca gtcttagtat ctgaagcagt taaaataata    420

cagggaagag atcttactgt gtggacatct catgatgtga atggcatatt cactgctaaa    480

ggagacttgt ggctgtcaga gaactgtgag gaaagtaact aa                       522


<210>  5046
<211>  173
<212>  PRT
<213>  Homosapiens

<400>  5046

Met Gly Ser Tyr Val Gly Leu Phe Pro Thr Thr Leu Ala Arg Ala Pro 
1               5                   10                  15      


Ser Phe Cys Arg Ile Trp Ile Pro Arg Tyr Asp Glu Ile Ala Arg Pro 
            20                  25                  30          


Leu Tyr Thr Leu Ile Lys Glu Thr Gln Lys Ala Asn Thr His Leu Val 
        35                  40                  45              


Lys Trp Thr Pro Glu Ala Glu Val Ala Phe Gln Ala Leu Lys Lys Ala 
    50                  55                  60                  


Val Thr Gln Ala Pro Val Leu Ser Leu Pro Thr Gly Gln Asp Phe Ser 
65                  70                  75                  80  


Leu Tyr Val Thr Glu Lys Thr Gly Ile Ala Leu Gly Val Leu Thr Gln 
                85                  90                  95      


Ile Arg Gly Met Ser Leu Gln Ser Val Ala Tyr Leu Ser Lys Glu Ile 
            100                 105                 110         


Asp Val Val Ala Lys Gly Trp Pro Leu Cys Leu Gln Val Val Val Ala 
        115                 120                 125             


Val Ala Val Leu Val Ser Glu Ala Val Lys Ile Ile Gln Gly Arg Asp 
    130                 135                 140                 


Leu Thr Val Trp Thr Ser His Asp Val Asn Gly Ile Phe Thr Ala Lys 
145                 150                 155                 160 


Gly Asp Leu Trp Leu Ser Glu Asn Cys Glu Glu Ser Asn 
                165                 170             


<210>  5047
<211>  2712
<212>  DNA
<213>  Homosapiens

<400>  5047
tgagttgctt cagcatcctg gtgttgctgt gccgtgggtc ctgtgcggtc acttagccaa     60

gatgcctgag gaaacccaga cccaagacca accgatggag gaggaggagg ttgagacatt    120

cgcctttcag gcagaaattg cccagttgat gtcattgatc atcaatactt tctactcgaa    180

caaagagatc tttctgagag agctcatttc aaattcatca gatgcattgg acaaaatctg    240

gtatgaaagc ttgacagatc ccagtaaatt agactctggg aaagagctgc atattaacct    300

tataccaaac aaacaagatc aaactctcac tattgtggat actggaattg gaatgaccaa    360

ggctgacttg atcaataacc ttggtactat cgccaagtct gggaccaaag cgttcatgga    420

agctttgcag gctggtgcag atatctctat gattggccag ttcggtgtta gtttttattc    480

tgcttatttg gttgctgaga aagtaactgt gatcaccaaa cataatgatg atgagcaact    540

gaagaaaagg aagacaaaga agaagaaaaa gaaaaagaag agaaagagtc caaagacaaa    600

cctgaaattg aagatgttgg ttctgatgag gaagaagaaa agaaggatgg tgacaagaag    660

aagaagaaga ctaaggaaaa gtacatcgac caagaagaac tcaacaaaac aaagcccatc    720

tggaccagaa atcccgacga tattactaat gaggagtacg gagaattctg caagaacttg    780

accaatgact gggaagatca cttggcagtg aagcattttt cagttgaagg acagttggaa    840

ttcagagccc ttctatttgt cccatgacgt gctccttttg acctgtttga aaacagaaag    900

aaaaagaaca acatcaaatt gtatgtacgc agagatttca tcatggataa ctgtgaggag    960

ctaatccctg aatatctgaa cttcattaga ggggtggtag actcggagga tctccctcta   1020

aacatttccc gtgagatgtt gcaacaaagt aaaattttga aagttatcag gaaaaatttg   1080

gtcaaaaaat gcttagaact ctttacagaa ctggcggaag ataaagagaa ctgcaagaaa   1140

ttctatgagc agttctctaa aaacataaag cttggaatac aagaagactc tcaaaatcgg   1200

aagaagcttt cagagctgtt aaggtactac acgtctgcct ctggtgatga gatggtttct   1260

ctcaaggact actgcaccag aatgaaggaa aaacagaaac atatctatta tatcacaggt   1320

gagaccaagg accaggtagc taactcagcc tttgtggaac gtcttgggaa acatggctta   1380

gaagtgatct atatgattga gcccattgat gagtactgtg tccaacagct gaaggaattt   1440

gaggggaaga ctttagtgcc agtcaccaaa gaaggcctgg aacttccaga ggatgaagaa   1500

aagaaaaaga aataggaaga gaaaaaacaa tgtttgagaa cctctgcaaa accatgaaag   1560

acatattgga gaaaaaagtt gaaaaggtgg ttgtgtcaaa ccgattggtg acgtctccat   1620

gctgtattgt cacaagcaca tatggctgga cagaaaacat ggagagaatc atgaaagctc   1680

aagccctaag agacaactca acaatgggtt atatggcagc caagaaacac ctggagataa   1740

atcctgatga ttccattatt gagaccttaa ggcaaaaggc agaggctgat aagaatgaca   1800

agtctgtgaa ggatctgctc atcttgcttt acgaaactgc actcctgtct tctggcttca   1860

gtctggaaga tccccagaca catgctaaca ggacctacag gatgatcaaa cttggtctgg   1920

gtattgatga agatgatcct gctgctgatg ataccagtgc tgctgtaact gaagaaatgc   1980

cgcccctcga aggagatgac gacacatcat gcatggaaga agtagactaa cctctggcta   2040

agggatgact taactgttca atactctaca attcctccga taatatatat tcaaggatgt   2100

ttttctttat ttttgttaat attaaaaagt ctgtacggca tgacaacaac tactttaagg   2160

ggaagataag atttctgtct actaagtgat gctgtgatac cttaggcact aaagcagagc   2220

tagtaatgct ttttgagttt cacgtcggtt tattttcaca gattggggta acgtgcgttg   2280

taagatgtat gtaacatgat gttaactttg tggtctaaag tgtttagctg tcaagccgga   2340

ttcctaagta gaccaaatct tgttatcgaa gtgttcctga gctatacctt gatgtttaga   2400

aaagtatttg ttacatcttg taggatctac tttttgaact tttcatcccc tatagttgac   2460

aattctgcat gtactagtcc tctagaaata ggttaaactg aagcaacttg atggaaggat   2520

ctctccacag ggcttgtttt ccaaagaaaa gtattgtttg gaggagcaaa gttataagcc   2580

tacctaagca tatcataaag ctgtttaaaa ataactcaga cccggtcttg tggatggaaa   2640

tgtagtgctc gagtcacatt cttcttatag ttgtaacaaa tacagatgag ttaaaagaaa   2700

aaaaaagaaa aa                                                       2712


<210>  5048
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  5048

Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg 
1               5                   10                  15      


Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg Glu Met 
            20                  25                  30          


Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu Val Lys 
        35                  40                  45              


Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu Asn Cys 
    50                  55                  60                  


Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly Ile Gln 
65                  70                  75                  80  


Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg Tyr Tyr 
                85                  90                  95      


Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr Cys Thr 
            100                 105                 110         


Arg Met Lys Glu Lys Gln Lys His Ile Tyr Tyr Ile Thr Gly Glu Thr 
        115                 120                 125             


Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Gly Lys His 
    130                 135                 140                 


Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr Cys Val 
145                 150                 155                 160 


Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Pro Val Thr Lys 
                165                 170                 175     


Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Lys Lys Lys Lys 
            180                 185                 190 


<210>  5049
<211>  2723
<212>  DNA
<213>  Homosapiens

<400>  5049
ttcagcatcc tggtgttgct gtgccgtggg tcctgtgcgg tcacttagcc aagatgcctg     60

aggaaaccca gacccaagac caaccgatgg aggaggagga ggttgagaca ttcgcctttc    120

aggcagaaat tgcccagttg atgtcattga tcatcaatac tttctactcg aacaaagaga    180

tctttctgag agagctcatt tcaaattcat cagatgcatt ggacaaaatc tggtatgaaa    240

gcttgacaga tcccagtaaa ttagactctg ggaaagagct gcatattaac cttataccaa    300

acaaacaaga tcaaactctc actattgtgg atactggaat tggaatgacc aaggctgact    360

tgatcaataa ccttggtgaa cgtatgggtc gtggaacaaa ggttatccta cacctgaaag    420

aagaccaaac tgagtacttg gaggaacaaa gaataaagga gattgtgaag aaacattctc    480

agcttattgg atatcccatt actctttttg tggagaagga atgtgataaa gaagtcagcg    540

acgatgagac tgaagaaaag gaagacaaag aagaagaaaa agaaaaagaa gagaaagagt    600

ccaaagacaa acctgaaatt gaagatgttg gttctgatga ggaagaagaa aagaaggatg    660

gtgacaagaa gaagaagaag actaaggaaa agtacatcga ccaagaagaa ctcaacaaaa    720

caaagcccat ctggaccaga aatcccgacg atattactaa tgaggagtac ggagaattct    780

gcaagaactt gaccaatgac tgggaagatc acttggcagt gaagcatttt tcagttgaag    840

gacagttgga attcagagcc cttctatttg tcccatgacg tgctcctttt gacctgtttg    900

aaaacagaaa gaaaaagaac aacatcaaat tgtatgtacg cagagatttc atcatggata    960

actgtgagga gctaatccct gaatatctga acttcattag aggggtggta gactcggagg   1020

atctccctct aaacatttcc cgtgagatgt tgcaacaaag taaaattttg aaagttatca   1080

ggaaaaattt ggtcaaaaaa tgcttagaac tctttacaga actggcggaa gataaagaga   1140

actgcaagaa attctatgag cagttctcta aaaacataaa gcttggaata caagaagact   1200

ctcaaaatcg gaagaagctt tcagagctgt taaggtacta cacgtctgcc tctggtgatg   1260

agatggtttc tctcaaggac tactgcacca gaatgaagga aaaacagaaa catatctatt   1320

atatcacagg tgagaccaag gaccaggtag ctaactcagc ctttgtggaa cgtcttggga   1380

aacatggctt agaagtgatc tatatgattg agcccattga tgagtactgt gtccaacagc   1440

tgaaggaatt tgaggggaag actttagtgc cagtcaccaa agaaggcctg gaacttccag   1500

aggatgaaga aaagaaaaag aaataggaag agaaaaaaca atgtttgaga acctctgcaa   1560

aaccatgaaa gacatattgg agaaaaaagt tgaaaaggtg gttgtgtcaa accgattggt   1620

gacgtctcca tgctgtattg tcacaagcac atatggctgg acagaaaaca tggagagaat   1680

catgaaagct caagccctaa gagacaactc aacaatgggt tatatggcag ccaagaaaca   1740

cctggagata aatcctgatg attccattat tgagacctta aggcaaaagg cagaggctga   1800

taagaatgac aagtctgtga aggatctgct catcttgctt tacgaaactg cactcctgtc   1860

ttctggcttc agtctggaag atccccagac acatgctaac aggacctaca ggatgatcaa   1920

acttggtctg ggtattgatg aagatgatcc tgctgctgat gataccagtg ctgctgtaac   1980

tgaagaaatg ccgcccctcg aaggagatga cgacacatca tgcatggaag aagtagacta   2040

acctctggct aagggatgac ttaactgttc aatactctac aattcctccg ataatatata   2100

ttcaaggatg tttttcttta tttttgttaa tattaaaaag tctgtacggc atgacaacaa   2160

ctactttaag gggaagataa gatttctgtc tactaagtga tgctgtgata ccttaggcac   2220

taaagcagag ctagtaatgc tttttgagtt tcacgtcggt ttattttcac agattggggt   2280

aacgtgcgtt gtaagatgta tgtaacatga tgttaacttt gtggtctaaa gtgtttagct   2340

gtcaagccgg attcctaagt agaccaaatc ttgttatcga agtgttcctg agctatacct   2400

tgatgtttag aaaagtattt gttacatctt gtaggatcta ctttttgaac ttttcatccc   2460

ctatagttga caattctgca tgtactagtc ctctagaaat aggttaaact gaagcaactt   2520

gatggaagga tctctccaca gggcttgttt tccaaagaaa agtattgttt ggaggagcaa   2580

agttataagc ctacctaagc atatcataaa gctgtttaaa aataactcag acccggtctt   2640

gtggatggaa atgtagtgct cgagtcacat tcttcttata gttgtaacaa atacagatga   2700

gttaaaagaa aaaaaaagaa aaa                                           2723


<210>  5050
<211>  274
<212>  PRT
<213>  Homosapiens

<400>  5050

Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu 
1               5                   10                  15      


Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu 
            20                  25                  30          


Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu 
        35                  40                  45              


Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Trp Tyr Glu Ser Leu 
    50                  55                  60                  


Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu 
65                  70                  75                  80  


Ile Pro Asn Lys Gln Asp Gln Thr Leu Thr Ile Val Asp Thr Gly Ile 
                85                  90                  95      


Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Glu Arg Met Gly 
            100                 105                 110         


Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr 
        115                 120                 125             


Leu Glu Glu Gln Arg Ile Lys Glu Ile Val Lys Lys His Ser Gln Leu 
    130                 135                 140                 


Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys Glu Cys Asp Lys Glu 
145                 150                 155                 160 


Val Ser Asp Asp Glu Thr Glu Glu Lys Glu Asp Lys Glu Glu Glu Lys 
                165                 170                 175     


Glu Lys Glu Glu Lys Glu Ser Lys Asp Lys Pro Glu Ile Glu Asp Val 
            180                 185                 190         


Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly Asp Lys Lys Lys Lys 
        195                 200                 205             


Lys Thr Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys 
    210                 215                 220                 


Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile Thr Asn Glu Glu Tyr Gly 
225                 230                 235                 240 


Glu Phe Cys Lys Asn Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val 
                245                 250                 255     


Lys His Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe 
            260                 265                 270         


Val Pro 
        


<210>  5051
<211>  2723
<212>  DNA
<213>  Homosapiens

<400>  5051
ttcagcatcc tggtgttgct gtgccgtggg tcctgtgcgg tcacttagcc aagatgcctg     60

aggaaaccca gacccaagac caaccgatgg aggaggagga ggttgagaca ttcgcctttc    120

aggcagaaat tgcccagttg atgtcattga tcatcaatac tttctactcg aacaaagaga    180

tctttctgag agagctcatt tcaaattcat cagatgcatt ggacaaaatc tggtatgaaa    240

gcttgacaga tcccagtaaa ttagactctg ggaaagagct gcatattaac cttataccaa    300

acaaacaaga tcaaactctc actattgtgg atactggaat tggaatgacc aaggctgact    360

tgatcaataa ccttggtgaa cgtatgggtc gtggaacaaa ggttatccta cacctgaaag    420

aagaccaaac tgagtacttg gaggaacaaa gaataaagga gattgtgaag aaacattctc    480

agcttattgg atatcccatt actctttttg tggagaagga atgtgataaa gaagtcagcg    540

acgatgagac tgaagaaaag gaagacaaag aagaagaaaa agaaaaagaa gagaaagagt    600

ccaaagacaa acctgaaatt gaagatgttg gttctgatga ggaagaagaa aagaaggatg    660

gtgacaagaa gaagaagaag actaaggaaa agtacatcga ccaagaagaa ctcaacaaaa    720

caaagcccat ctggaccaga aatcccgacg atattactaa tgaggagtac ggagaattct    780

gcaagaactt gaccaatgac tgggaagatc acttggcagt gaagcatttt tcagttgaag    840

gacagttgga attcagagcc cttctatttg tcccatgacg tgctcctttt gacctgtttg    900

aaaacagaaa gaaaaagaac aacatcaaat tgtatgtacg cagagatttc atcatggata    960

actgtgagga gctaatccct gaatatctga acttcattag aggggtggta gactcggagg   1020

atctccctct aaacatttcc cgtgagatgt tgcaacaaag taaaattttg aaagttatca   1080

ggaaaaattt ggtcaaaaaa tgcttagaac tctttacaga actggcggaa gataaagaga   1140

actgcaagaa attctatgag cagttctcta aaaacataaa gcttggaata caagaagact   1200

ctcaaaatcg gaagaagctt tcagagctgt taaggtacta cacgtctgcc tctggtgatg   1260

agatggtttc tctcaaggac tactgcacca gaatgaagga aaaacagaaa catatctatt   1320

atatcacagg tgagaccaag gaccaggtag ctaactcagc ctttgtggaa cgtcttggga   1380

aacatggctt agaagtgatc tatatgattg agcccattga tgagtactgt gtccaacagc   1440

tgaaggaatt tgaggggaag actttagtgc cagtcaccaa agaaggcctg gaacttccag   1500

aggatgaaga aaagaaaaag aaataggaag agaaaaaaca atgtttgaga acctctgcaa   1560

aaccatgaaa gacatattgg agaaaaaagt tgaaaaggtg gttgtgtcaa accgattggt   1620

gacgtctcca tgctgtattg tcacaagcac atatggctgg acagaaaaca tggagagaat   1680

catgaaagct caagccctaa gagacaactc aacaatgggt tatatggcag ccaagaaaca   1740

cctggagata aatcctgatg attccattat tgagacctta aggcaaaagg cagaggctga   1800

taagaatgac aagtctgtga aggatctgct catcttgctt tacgaaactg cactcctgtc   1860

ttctggcttc agtctggaag atccccagac acatgctaac aggacctaca ggatgatcaa   1920

acttggtctg ggtattgatg aagatgatcc tgctgctgat gataccagtg ctgctgtaac   1980

tgaagaaatg ccgcccctcg aaggagatga cgacacatca tgcatggaag aagtagacta   2040

acctctggct aagggatgac ttaactgttc aatactctac aattcctccg ataatatata   2100

ttcaaggatg tttttcttta tttttgttaa tattaaaaag tctgtacggc atgacaacaa   2160

ctactttaag gggaagataa gatttctgtc tactaagtga tgctgtgata ccttaggcac   2220

taaagcagag ctagtaatgc tttttgagtt tcacgtcggt ttattttcac agattggggt   2280

aacgtgcgtt gtaagatgta tgtaacatga tgttaacttt gtggtctaaa gtgtttagct   2340

gtcaagccgg attcctaagt agaccaaatc ttgttatcga agtgttcctg agctatacct   2400

tgatgtttag aaaagtattt gttacatctt gtaggatcta ctttttgaac ttttcatccc   2460

ctatagttga caattctgca tgtactagtc ctctagaaat aggttaaact gaagcaactt   2520

gatggaagga tctctccaca gggcttgttt tccaaagaaa agtattgttt ggaggagcaa   2580

agttataagc ctacctaagc atatcataaa gctgtttaaa aataactcag acccggtctt   2640

gtggatggaa atgtagtgct cgagtcacat tcttcttata gttgtaacaa atacagatga   2700

gttaaaagaa aaaaaaagaa aaa                                           2723


<210>  5052
<211>  158
<212>  PRT
<213>  Homosapiens

<400>  5052

Met Lys Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn 
1               5                   10                  15      


Arg Leu Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp 
            20                  25                  30          


Thr Glu Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn 
        35                  40                  45              


Ser Thr Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro 
    50                  55                  60                  


Asp Asp Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys 
65                  70                  75                  80  


Asn Asp Lys Ser Val Lys Asp Leu Leu Ile Leu Leu Tyr Glu Thr Ala 
                85                  90                  95      


Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn 
            100                 105                 110         


Arg Thr Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp 
        115                 120                 125             


Pro Ala Ala Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro 
    130                 135                 140                 


Leu Glu Gly Asp Asp Asp Thr Ser Cys Met Glu Glu Val Asp 
145                 150                 155             


<210>  5053
<211>  2712
<212>  DNA
<213>  Homosapiens

<400>  5053
tgagttgctt cagcatcctg gtgttgctgt gccgtgggtc ctgtgcggtc acttagccaa     60

gatgcctgag gaaacccaga cccaagacca accgatggag gaggaggagg ttgagacatt    120

cgcctttcag gcagaaattg cccagttgat gtcattgatc atcaatactt tctactcgaa    180

caaagagatc tttctgagag agctcatttc aaattcatca gatgcattgg acaaaatctg    240

gtatgaaagc ttgacagatc ccagtaaatt agactctggg aaagagctgc atattaacct    300

tataccaaac aaacaagatc aaactctcac tattgtggat actggaattg gaatgaccaa    360

ggctgacttg atcaataacc ttggtactat cgccaagtct gggaccaaag cgttcatgga    420

agctttgcag gctggtgcag atatctctat gattggccag ttcggtgtta gtttttattc    480

tgcttatttg gttgctgaga aagtaactgt gatcaccaaa cataatgatg atgagcaact    540

gaagaaaagg aagacaaaga agaagaaaaa gaaaaagaag agaaagagtc caaagacaaa    600

cctgaaattg aagatgttgg ttctgatgag gaagaagaaa agaaggatgg tgacaagaag    660

aagaagaaga ctaaggaaaa gtacatcgac caagaagaac tcaacaaaac aaagcccatc    720

tggaccagaa atcccgacga tattactaat gaggagtacg gagaattctg caagaacttg    780

accaatgact gggaagatca cttggcagtg aagcattttt cagttgaagg acagttggaa    840

ttcagagccc ttctatttgt cccatgacgt gctccttttg acctgtttga aaacagaaag    900

aaaaagaaca acatcaaatt gtatgtacgc agagatttca tcatggataa ctgtgaggag    960

ctaatccctg aatatctgaa cttcattaga ggggtggtag actcggagga tctccctcta   1020

aacatttccc gtgagatgtt gcaacaaagt aaaattttga aagttatcag gaaaaatttg   1080

gtcaaaaaat gcttagaact ctttacagaa ctggcggaag ataaagagaa ctgcaagaaa   1140

ttctatgagc agttctctaa aaacataaag cttggaatac aagaagactc tcaaaatcgg   1200

aagaagcttt cagagctgtt aaggtactac acgtctgcct ctggtgatga gatggtttct   1260

ctcaaggact actgcaccag aatgaaggaa aaacagaaac atatctatta tatcacaggt   1320

gagaccaagg accaggtagc taactcagcc tttgtggaac gtcttgggaa acatggctta   1380

gaagtgatct atatgattga gcccattgat gagtactgtg tccaacagct gaaggaattt   1440

gaggggaaga ctttagtgcc agtcaccaaa gaaggcctgg aacttccaga ggatgaagaa   1500

aagaaaaaga aataggaaga gaaaaaacaa tgtttgagaa cctctgcaaa accatgaaag   1560

acatattgga gaaaaaagtt gaaaaggtgg ttgtgtcaaa ccgattggtg acgtctccat   1620

gctgtattgt cacaagcaca tatggctgga cagaaaacat ggagagaatc atgaaagctc   1680

aagccctaag agacaactca acaatgggtt atatggcagc caagaaacac ctggagataa   1740

atcctgatga ttccattatt gagaccttaa ggcaaaaggc agaggctgat aagaatgaca   1800

agtctgtgaa ggatctgctc atcttgcttt acgaaactgc actcctgtct tctggcttca   1860

gtctggaaga tccccagaca catgctaaca ggacctacag gatgatcaaa cttggtctgg   1920

gtattgatga agatgatcct gctgctgatg ataccagtgc tgctgtaact gaagaaatgc   1980

cgcccctcga aggagatgac gacacatcat gcatggaaga agtagactaa cctctggcta   2040

agggatgact taactgttca atactctaca attcctccga taatatatat tcaaggatgt   2100

ttttctttat ttttgttaat attaaaaagt ctgtacggca tgacaacaac tactttaagg   2160

ggaagataag atttctgtct actaagtgat gctgtgatac cttaggcact aaagcagagc   2220

tagtaatgct ttttgagttt cacgtcggtt tattttcaca gattggggta acgtgcgttg   2280

taagatgtat gtaacatgat gttaactttg tggtctaaag tgtttagctg tcaagccgga   2340

ttcctaagta gaccaaatct tgttatcgaa gtgttcctga gctatacctt gatgtttaga   2400

aaagtatttg ttacatcttg taggatctac tttttgaact tttcatcccc tatagttgac   2460

aattctgcat gtactagtcc tctagaaata ggttaaactg aagcaacttg atggaaggat   2520

ctctccacag ggcttgtttt ccaaagaaaa gtattgtttg gaggagcaaa gttataagcc   2580

tacctaagca tatcataaag ctgtttaaaa ataactcaga cccggtcttg tggatggaaa   2640

tgtagtgctc gagtcacatt cttcttatag ttgtaacaaa tacagatgag ttaaaagaaa   2700

aaaaaagaaa aa                                                       2712


<210>  5054
<211>  158
<212>  PRT
<213>  Homosapiens

<400>  5054

Met Lys Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn 
1               5                   10                  15      


Arg Leu Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp 
            20                  25                  30          


Thr Glu Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn 
        35                  40                  45              


Ser Thr Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro 
    50                  55                  60                  


Asp Asp Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys 
65                  70                  75                  80  


Asn Asp Lys Ser Val Lys Asp Leu Leu Ile Leu Leu Tyr Glu Thr Ala 
                85                  90                  95      


Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn 
            100                 105                 110         


Arg Thr Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp 
        115                 120                 125             


Pro Ala Ala Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro 
    130                 135                 140                 


Leu Glu Gly Asp Asp Asp Thr Ser Cys Met Glu Glu Val Asp 
145                 150                 155             


<210>  5055
<211>  2938
<212>  DNA
<213>  Homosapiens

<400>  5055
tgagttgctt cagcatcctg gtgttgctgt gccgtgggtc ctgtgcggtc acttagccaa     60

gatgcctgag gaaacccaga cccaagacca accgatggag gaggaggagg ttgagacatt    120

cgcctttcag gcagaaattg cccagttgat gtcattgatc atcaatactt tctactcgaa    180

caaagagatc tttctgagag agctcatttc aaattcatca gatgcattgg acaaaatctg    240

gtatgaaagc ttgacagatc ccagtaaatt agactctggg aaagagctgc atattaacct    300

tataccaaac aaacaagatc aaactctcac tattgtggat actggaattg gaatgaccaa    360

ggctgacttg atcaataacc ttggtactat cgccaagtct gggaccaaag cgttcatgga    420

agctttgcag gctggtgcag atatctctat gattggccag ttcggtgtta gtttttattc    480

tgcttatttg gttgctgaga aagtaactgt gatcaccaaa cataatgatg atgagcagta    540

cgcctgggag tcctcagcag ggggatcatt cacagtgagg acagacacag gtgaacgtat    600

gggtcgtgga acaaaggtta tcctacacct gaaagaagac caaactgagt acttggagga    660

acaaagaata aaggagattg tgaagaaaca ttctcagctt attggatatc ccattactct    720

ttttgtggag aaggaatgtg ataaagaagt cagcgacgat gagactgaag aaaaggaaga    780

caaagaagaa gaaaaagaaa aagaagagaa agagtccaaa gacaaacctg aaattgaaga    840

tgttggttct gatgaggaag aagaaaagaa ggatggtgac aagaagaaga agaagactaa    900

ggaaaagtac atcgaccaag aagaactcaa caaaacaaag cccatctgga ccagaaatcc    960

cgacgatatt actaatgagg agtacggaga attctgcaag aacttgacca atgactggga   1020

agatcacttg gcagtgaagc atttttcagt tgaaggacag ttggaattca gagcccttct   1080

atttgtccca tgacgtgctc cttttgacct gtttgaaaac agaaagaaaa agaacaacat   1140

caaattgtat gtacgcagag atttcatcat ggataactgt gaggagctaa tccctgaata   1200

tctgaacttc attagagggg tggtagactc ggaggatctc cctctaaaca tttcccgtga   1260

gatgttgcaa caaagtaaaa ttttgaaagt tatcaggaaa aatttggtca aaaaatgctt   1320

agaactcttt acagaactgg cggaagataa agagaactgc aagaaattct atgagcagtt   1380

ctctaaaaac ataaagcttg gaatacaaga agactctcaa aatcggaaga agctttcaga   1440

gctgttaagg tactacacgt ctgcctctgg tgatgagatg gtttctctca aggactactg   1500

caccagaatg aaggaaaaac agaaacatat ctattatatc acaggtgaga ccaaggacca   1560

ggtagctaac tcagcctttg tggaacgtct tgggaaacat ggcttagaag tgatctatat   1620

gattgagccc attgatgagt actgtgtcca acagctgaag gaatttgagg ggaagacttt   1680

agtgccagtc accaaagaag gcctggaact tccagaggat gaagaaaaga aaaagaaata   1740

ggaagagaaa aaacaatgtt tgagaacctc tgcaaaacca tgaaagacat attggagaaa   1800

aaagttgaaa aggtggttgt gtcaaaccga ttggtgacgt ctccatgctg tattgtcaca   1860

agcacatatg gctggacaga aaacatggag agaatcatga aagctcaagc cctaagagac   1920

aactcaacaa tgggttatat ggcagccaag aaacacctgg agataaatcc tgatgattcc   1980

attattgaga ccttaaggca aaaggcagag gctgataaga atgacaagtc tgtgaaggat   2040

ctgctcatct tgctttacga aactgcactc ctgtcttctg gcttcagtct ggaagatccc   2100

cagacacatg ctaacaggac ctacaggatg atcaaacttg gtctgggtat tgatgaagat   2160

gatcctgctg ctgatgatac cagtgctgct gtaactgaag aaatgccgcc cctcgaagga   2220

gatgacgaca catcatgcat ggaagaagta gactaacctc tggctaaggg atgacttaac   2280

tgttcaatac tctacaattc ctccgataat atatattcaa ggatgttttt ctttattttt   2340

gttaatatta aaaagtctgt acggcatgac aacaactact ttaaggggaa gataagattt   2400

ctgtctacta agtgatgctg tgatacctta ggcactaaag cagagctagt aatgcttttt   2460

gagtttcacg tcggtttatt ttcacagatt ggggtaacgt gcgttgtaag atgtatgtaa   2520

catgatgtta actttgtggt ctaaagtgtt tagctgtcaa gccggattcc taagtagacc   2580

aaatcttgtt atcgaagtgt tcctgagcta taccttgatg tttagaaaag tatttgttac   2640

atcttgtagg atctactttt tgaacttttc atcccctata gttgacaatt ctgcatgtac   2700

tagtcctcta gaaataggtt aaactgaagc aacttgatgg aaggatctct ccacagggct   2760

tgttttccaa agaaaagtat tgtttggagg agcaaagtta taagcctacc taagcatatc   2820

ataaagctgt ttaaaaataa ctcagacccg gtcttgtgga tggaaatgta gtgctcgagt   2880

cacattcttc ttatagttgt aacaaataca gatgagttaa aagaaaaaaa aagaaaaa     2938


<210>  5056
<211>  158
<212>  PRT
<213>  Homosapiens

<400>  5056

Met Lys Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn 
1               5                   10                  15      


Arg Leu Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp 
            20                  25                  30          


Thr Glu Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn 
        35                  40                  45              


Ser Thr Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro 
    50                  55                  60                  


Asp Asp Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys 
65                  70                  75                  80  


Asn Asp Lys Ser Val Lys Asp Leu Leu Ile Leu Leu Tyr Glu Thr Ala 
                85                  90                  95      


Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn 
            100                 105                 110         


Arg Thr Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp 
        115                 120                 125             


Pro Ala Ala Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro 
    130                 135                 140                 


Leu Glu Gly Asp Asp Asp Thr Ser Cys Met Glu Glu Val Asp 
145                 150                 155             


<210>  5057
<211>  2717
<212>  DNA
<213>  Homosapiens

<400>  5057
tgagttgctt cagcatcctg gtgttgctgt gccgtgggtc ctgtgcggtc acttagccaa     60

gatgcctgag gaaacccaga cccaagacca accgatggag gaggaggagg ttgagacatt    120

cgcctttcag gcagaaattg cccagttgat gtcattgatc atcaatactt tctactcgaa    180

caaagagatc tttctgagag agctcatttc aaattcatca gatgcattgg acaaaatctg    240

gtatgaaagc ttgacagatc ccagtaaatt agactctggg aaagagctgc atattaacct    300

tataccaaac aaacaagatc aaactctcac tattgtggat actggaattg gaatgaccaa    360

ggctgacttg atcaataacc ttggtactat cgccaagtct gggaccaaag cgttcatgga    420

agctttgcag gctggtgcag atatctctat gattggccag ttcggtgtta gtttttattc    480

tgcttatttg gttgctgaga aagtaactgt gatcaccaaa cataatgatg atgagcagta    540

cgcctgggag tcctcagcag ggggatcatt cacagtgagg acagacacag gtgaacgtat    600

gggtcgtgga acaagaagat gttggttctg atgaggaaga agaaaagaag gatggtgaca    660

agaagaagaa gaagactaag gaaaagtaca tcgaccaaga agaactcaac aaaacaaagc    720

ccatctggac cagaaatccc gacgatatta ctaatgagga gtacggagaa ttctgcaaga    780

acttgaccaa tgactgggaa gatcacttgg cagtgaagca tttttcagtt gaaggacagt    840

tggaattcag agcccttcta tttgtcccat gacgtgctcc ttttgacctg tttgaaaaca    900

gaaagaaaaa gaacaacatc aaattgtatg tacgcagaga tttcatcatg gataactgtg    960

aggagctaat ccctgaatat ctgaacttca ttagaggggt ggtagactcg gaggatctcc   1020

ctctaaacat ttcccgtgag atgttgcaac aaagtaaaat tttgaaagtt atcaggaaaa   1080

atttggtcaa aaaatgctta gaactcttta cagaactggc ggaagataaa gagaactgca   1140

agaaattcta tgagcagttc tctaaaaaca taaagcttgg aatacaagaa gactctcaaa   1200

atcggaagaa gctttcagag ctgttaaggt actacacgtc tgcctctggt gatgagatgg   1260

tttctctcaa ggactactgc accagaatga aggaaaaaca gaaacatatc tattatatca   1320

caggtgagac caaggaccag gtagctaact cagcctttgt ggaacgtctt gggaaacatg   1380

gcttagaagt gatctatatg attgagccca ttgatgagta ctgtgtccaa cagctgaagg   1440

aatttgaggg gaagacttta gtgccagtca ccaaagaagg cctggaactt ccagaggatg   1500

aagaaaagaa aaagaaatag gaagagaaaa aacaatgttt gagaacctct gcaaaaccat   1560

gaaagacata ttggagaaaa aagttgaaaa ggtggttgtg tcaaaccgat tggtgacgtc   1620

tccatgctgt attgtcacaa gcacatatgg ctggacagaa aacatggaga gaatcatgaa   1680

agctcaagcc ctaagagaca actcaacaat gggttatatg gcagccaaga aacacctgga   1740

gataaatcct gatgattcca ttattgagac cttaaggcaa aaggcagagg ctgataagaa   1800

tgacaagtct gtgaaggatc tgctcatctt gctttacgaa actgcactcc tgtcttctgg   1860

cttcagtctg gaagatcccc agacacatgc taacaggacc tacaggatga tcaaacttgg   1920

tctgggtatt gatgaagatg atcctgctgc tgatgatacc agtgctgctg taactgaaga   1980

aatgccgccc ctcgaaggag atgacgacac atcatgcatg gaagaagtag actaacctct   2040

ggctaaggga tgacttaact gttcaatact ctacaattcc tccgataata tatattcaag   2100

gatgtttttc tttatttttg ttaatattaa aaagtctgta cggcatgaca acaactactt   2160

taaggggaag ataagatttc tgtctactaa gtgatgctgt gataccttag gcactaaagc   2220

agagctagta atgctttttg agtttcacgt cggtttattt tcacagattg gggtaacgtg   2280

cgttgtaaga tgtatgtaac atgatgttaa ctttgtggtc taaagtgttt agctgtcaag   2340

ccggattcct aagtagacca aatcttgtta tcgaagtgtt cctgagctat accttgatgt   2400

ttagaaaagt atttgttaca tcttgtagga tctacttttt gaacttttca tcccctatag   2460

ttgacaattc tgcatgtact agtcctctag aaataggtta aactgaagca acttgatgga   2520

aggatctctc cacagggctt gttttccaaa gaaaagtatt gtttggagga gcaaagttat   2580

aagcctacct aagcatatca taaagctgtt taaaaataac tcagacccgg tcttgtggat   2640

ggaaatgtag tgctcgagtc acattcttct tatagttgta acaaatacag atgagttaaa   2700

agaaaaaaaa agaaaaa                                                  2717


<210>  5058
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  5058

Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg 
1               5                   10                  15      


Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg Glu Met 
            20                  25                  30          


Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu Val Lys 
        35                  40                  45              


Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu Asn Cys 
    50                  55                  60                  


Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly Ile Gln 
65                  70                  75                  80  


Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg Tyr Tyr 
                85                  90                  95      


Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr Cys Thr 
            100                 105                 110         


Arg Met Lys Glu Lys Gln Lys His Ile Tyr Tyr Ile Thr Gly Glu Thr 
        115                 120                 125             


Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Gly Lys His 
    130                 135                 140                 


Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr Cys Val 
145                 150                 155                 160 


Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Pro Val Thr Lys 
                165                 170                 175     


Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Lys Lys Lys Lys 
            180                 185                 190 


<210>  5059
<211>  2938
<212>  DNA
<213>  Homosapiens

<400>  5059
tgagttgctt cagcatcctg gtgttgctgt gccgtgggtc ctgtgcggtc acttagccaa     60

gatgcctgag gaaacccaga cccaagacca accgatggag gaggaggagg ttgagacatt    120

cgcctttcag gcagaaattg cccagttgat gtcattgatc atcaatactt tctactcgaa    180

caaagagatc tttctgagag agctcatttc aaattcatca gatgcattgg acaaaatctg    240

gtatgaaagc ttgacagatc ccagtaaatt agactctggg aaagagctgc atattaacct    300

tataccaaac aaacaagatc aaactctcac tattgtggat actggaattg gaatgaccaa    360

ggctgacttg atcaataacc ttggtactat cgccaagtct gggaccaaag cgttcatgga    420

agctttgcag gctggtgcag atatctctat gattggccag ttcggtgtta gtttttattc    480

tgcttatttg gttgctgaga aagtaactgt gatcaccaaa cataatgatg atgagcagta    540

cgcctgggag tcctcagcag ggggatcatt cacagtgagg acagacacag gtgaacgtat    600

gggtcgtgga acaaaggtta tcctacacct gaaagaagac caaactgagt acttggagga    660

acaaagaata aaggagattg tgaagaaaca ttctcagctt attggatatc ccattactct    720

ttttgtggag aaggaatgtg ataaagaagt cagcgacgat gagactgaag aaaaggaaga    780

caaagaagaa gaaaaagaaa aagaagagaa agagtccaaa gacaaacctg aaattgaaga    840

tgttggttct gatgaggaag aagaaaagaa ggatggtgac aagaagaaga agaagactaa    900

ggaaaagtac atcgaccaag aagaactcaa caaaacaaag cccatctgga ccagaaatcc    960

cgacgatatt actaatgagg agtacggaga attctgcaag aacttgacca atgactggga   1020

agatcacttg gcagtgaagc atttttcagt tgaaggacag ttggaattca gagcccttct   1080

atttgtccca tgacgtgctc cttttgacct gtttgaaaac agaaagaaaa agaacaacat   1140

caaattgtat gtacgcagag atttcatcat ggataactgt gaggagctaa tccctgaata   1200

tctgaacttc attagagggg tggtagactc ggaggatctc cctctaaaca tttcccgtga   1260

gatgttgcaa caaagtaaaa ttttgaaagt tatcaggaaa aatttggtca aaaaatgctt   1320

agaactcttt acagaactgg cggaagataa agagaactgc aagaaattct atgagcagtt   1380

ctctaaaaac ataaagcttg gaatacaaga agactctcaa aatcggaaga agctttcaga   1440

gctgttaagg tactacacgt ctgcctctgg tgatgagatg gtttctctca aggactactg   1500

caccagaatg aaggaaaaac agaaacatat ctattatatc acaggtgaga ccaaggacca   1560

ggtagctaac tcagcctttg tggaacgtct tgggaaacat ggcttagaag tgatctatat   1620

gattgagccc attgatgagt actgtgtcca acagctgaag gaatttgagg ggaagacttt   1680

agtgccagtc accaaagaag gcctggaact tccagaggat gaagaaaaga aaaagaaata   1740

ggaagagaaa aaacaatgtt tgagaacctc tgcaaaacca tgaaagacat attggagaaa   1800

aaagttgaaa aggtggttgt gtcaaaccga ttggtgacgt ctccatgctg tattgtcaca   1860

agcacatatg gctggacaga aaacatggag agaatcatga aagctcaagc cctaagagac   1920

aactcaacaa tgggttatat ggcagccaag aaacacctgg agataaatcc tgatgattcc   1980

attattgaga ccttaaggca aaaggcagag gctgataaga atgacaagtc tgtgaaggat   2040

ctgctcatct tgctttacga aactgcactc ctgtcttctg gcttcagtct ggaagatccc   2100

cagacacatg ctaacaggac ctacaggatg atcaaacttg gtctgggtat tgatgaagat   2160

gatcctgctg ctgatgatac cagtgctgct gtaactgaag aaatgccgcc cctcgaagga   2220

gatgacgaca catcatgcat ggaagaagta gactaacctc tggctaaggg atgacttaac   2280

tgttcaatac tctacaattc ctccgataat atatattcaa ggatgttttt ctttattttt   2340

gttaatatta aaaagtctgt acggcatgac aacaactact ttaaggggaa gataagattt   2400

ctgtctacta agtgatgctg tgatacctta ggcactaaag cagagctagt aatgcttttt   2460

gagtttcacg tcggtttatt ttcacagatt ggggtaacgt gcgttgtaag atgtatgtaa   2520

catgatgtta actttgtggt ctaaagtgtt tagctgtcaa gccggattcc taagtagacc   2580

aaatcttgtt atcgaagtgt tcctgagcta taccttgatg tttagaaaag tatttgttac   2640

atcttgtagg atctactttt tgaacttttc atcccctata gttgacaatt ctgcatgtac   2700

tagtcctcta gaaataggtt aaactgaagc aacttgatgg aaggatctct ccacagggct   2760

tgttttccaa agaaaagtat tgtttggagg agcaaagtta taagcctacc taagcatatc   2820

ataaagctgt ttaaaaataa ctcagacccg gtcttgtgga tggaaatgta gtgctcgagt   2880

cacattcttc ttatagttgt aacaaataca gatgagttaa aagaaaaaaa aagaaaaa     2938


<210>  5060
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  5060

Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg 
1               5                   10                  15      


Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg Glu Met 
            20                  25                  30          


Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu Val Lys 
        35                  40                  45              


Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu Asn Cys 
    50                  55                  60                  


Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly Ile Gln 
65                  70                  75                  80  


Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg Tyr Tyr 
                85                  90                  95      


Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr Cys Thr 
            100                 105                 110         


Arg Met Lys Glu Lys Gln Lys His Ile Tyr Tyr Ile Thr Gly Glu Thr 
        115                 120                 125             


Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Gly Lys His 
    130                 135                 140                 


Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr Cys Val 
145                 150                 155                 160 


Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Pro Val Thr Lys 
                165                 170                 175     


Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Lys Lys Lys Lys 
            180                 185                 190 


<210>  5061
<211>  806
<212>  DNA
<213>  Homosapiens

<400>  5061
ttcaatttta ggtaaaagaa acctttttac cagatagtga cgagtggcta ccatgattaa     60

taagtgacta gacctcatgg tcctcctcat actaaaaggt gaacagtgca agctgtcggt    120

ggatctacca ttctggggtc ttggggacag tggccctctt ctcacagctc ccggtgaatg    180

ctgcaatgat cattggtagg actgttaggc tttgtttctc aagaggataa tctgattggg    240

aaaagaataa gagtgcagct gcagcccatc cttgtgaaga aggtaccagt gcgctctcaa    300

agccaagtct tgaaaataat agcgaatgct gtattggata acagccatgc cagatacaga    360

gaagccacag atggcattgt caccagaaaa tggaagcaca aagcgctttg ggtaacagca    420

attcaagaat gactgcagag aaaatctatt aagaaattca aatgcagatt tcaatattta    480

ctccttttca ttctcttcct ctctctctcg ctcacttgct ctttttctct ctcccacctt    540

gtttttctcg ctctcctttt ttttgcatac agtttctcag taaaatacat ttgattaaat    600

tttataacaa acaagcttat gaaatgcaga tatacaaaaa ggaaaacata agaagcatgc    660

ataattctac cactgaaaaa tactactaaa atttggtatt taaacttttg aatgtttgtc    720

actgcacttg catgtgtgtg taaatataat ctccaactct gcagagaaat acaagaattg    780

ttatgaacct taataaactc ccaaaa                                         806


<210>  5062
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5062

Met Val Leu Leu Ile Leu Lys Gly Glu Gln Cys Lys Leu Ser Val Asp 
1               5                   10                  15      


Leu Pro Phe Trp Gly Leu Gly Asp Ser Gly Pro Leu Leu Thr Ala Pro 
            20                  25                  30          


Gly Glu Cys Cys Asn Asp His Trp 
        35                  40  


<210>  5063
<211>  513
<212>  DNA
<213>  Homosapiens

<400>  5063
atgaggccaa taaagagcct agaactcaga actgaatttg gagaaaagac gttagaaaag     60

acaggctcca gtgtgactca gcacagtgtt cacagcccat gctctcaaga atctcagctt    120

aggaggaggc aaagagccgc tctacagtaa ggtaaataag tcatttagtc aggaactctg    180

cacatttacc tctgcattta tcaaatattt gttgaaggaa ataataaaag aagtgaggag    240

gaagaagagg tttcctggga gaaagcactc gaggagcaat aggtgtcctc tttcatttcc    300

actaaatatg ctgctcaatg ccttgtggca taacagaatc aaaacttttc agatgccctg    360

ccgctttaac aagacccagg atatgtcaaa atggctccca cagaactttc atttgatctt    420

atctttcgct gtcacacaca tcgacctgca ttttcttttt tctttttgat tctttatgtc    480

tgcaaatgaa ctgatgtaat taaaaaggtg aag                                 513


<210>  5064
<211>  49
<212>  PRT
<213>  Homosapiens

<400>  5064

Met Arg Pro Ile Lys Ser Leu Glu Leu Arg Thr Glu Phe Gly Glu Lys 
1               5                   10                  15      


Thr Leu Glu Lys Thr Gly Ser Ser Val Thr Gln His Ser Val His Ser 
            20                  25                  30          


Pro Cys Ser Gln Glu Ser Gln Leu Arg Arg Arg Gln Arg Ala Ala Leu 
        35                  40                  45              


Gln 
    


<210>  5065
<211>  1271
<212>  DNA
<213>  Homosapiens

<400>  5065
tttgcagagt tggcagctgc aaacagttcg atccctctag tcccggctga gaaggagaaa     60

cagcgcctgc aagcttggca ctgcacacct ggggttgggg acaggacatg actaagcaca    120

gagctttctt cttttgaggc cacgcatgtg gtgcggagcg ggaccacctg catccacaca    180

gcccggcgca cctgctccta cttctgctta gcgtgtgagc agtgtggtga ccagggtctc    240

caccaggggg caggccagga ccgcctcaca gcactttcta ggcgttctct ggtcccgggc    300

tgggacacat acagggctta gtaaagttca tagatggtag ctaggcagcc ccaggcccca    360

ggtgacacct ctcccctgcc tgccctgtac tgcctgcctg cagcactcct gggaatcttg    420

tacgaagaca aggagagaca ggacttcatc ttcaccatct accactggtg gcaggctgtg    480

gccatcttca ccgtgtacct gggctcgagc ctgcacatga aggctaagct ggcgatgctg    540

ctggtgacgc tggtggcggc cgcggtctcc tacctgcgga tggagcagaa gctgcggcgg    600

ggcgtggccc cgcctcagcc ccgcatcccg cggccccagc acaaggtgcg cggttaccgc    660

tacttggagg acaactcgga ggagagcgac gctgaggacg agcatgggga cggcgcggag    720

gaggaggcgc cgcccgcggg gcccaggcct ggccccgagc ccgctggact cggccgccgg    780

ccctgcccgt acgaacaggc gcagagggga gacggaccgg aggagcagtg aggggccgcc    840

tggtccccgg actcagcctc cctcctcgcc ggcctcagtt taccacgtct taggtcgggg    900

ggaccccctc tgagtcccgc gctgtattca aaggcccctg tctcccctcc cccacattgg    960

ggacgcccct cccagagccc gggtcacctc cgggcttccg cagccccctc caaggcggag   1020

tggagccttg ggaacccctc ggccaagcac aggggttcga aaatacagct gaaaccctgc   1080

gggcccttag cacgcgcccc agcgcgggag cagggtcagg gtcttcttgc gacccggccc   1140

cgctccagat cctcccagct gtcggccgcg gacccgggcc gcgtgtgacc gcgctttgca   1200

cctcctatcc ccagggtccg ccgagagcca cgattttttt acagaaaatg agcaataaag   1260

agattttgta c                                                        1271


<210>  5066
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  5066

Met Val Ala Arg Gln Pro Gln Ala Pro Gly Asp Thr Ser Pro Leu Pro 
1               5                   10                  15      


Ala Leu Tyr Cys Leu Pro Ala Ala Leu Leu Gly Ile Leu Tyr Glu Asp 
            20                  25                  30          


Lys Glu Arg Gln Asp Phe Ile Phe Thr Ile Tyr His Trp Trp Gln Ala 
        35                  40                  45              


Val Ala Ile Phe Thr Val Tyr Leu Gly Ser Ser Leu His Met Lys Ala 
    50                  55                  60                  


Lys Leu Ala Met Leu Leu Val Thr Leu Val Ala Ala Ala Val Ser Tyr 
65                  70                  75                  80  


Leu Arg Met Glu Gln Lys Leu Arg Arg Gly Val Ala Pro Pro Gln Pro 
                85                  90                  95      


Arg Ile Pro Arg Pro Gln His Lys Val Arg Gly Tyr Arg Tyr Leu Glu 
            100                 105                 110         


Asp Asn Ser Glu Glu Ser Asp Ala Glu Asp Glu His Gly Asp Gly Ala 
        115                 120                 125             


Glu Glu Glu Ala Pro Pro Ala Gly Pro Arg Pro Gly Pro Glu Pro Ala 
    130                 135                 140                 


Gly Leu Gly Arg Arg Pro Cys Pro Tyr Glu Gln Ala Gln Arg Gly Asp 
145                 150                 155                 160 


Gly Pro Glu Glu Gln 
                165 


<210>  5067
<211>  1233
<212>  DNA
<213>  Homosapiens

<400>  5067
gggggtgagg caccccccgc aatgcgggga gggctgagac tggggtctgg gctgttccgg     60

acttcaacac tcaccccttg tccccccgca gggctatggc gtgtgcttgg tggggctgga    120

gcggctggct tacctcctcg tggcttacag cctgggcacc tcagccgcct cactcctggg    180

cctgctgggc ctgtggctgc cacgcccggt gcccctcatg gctggagcag gggtgcacct    240

gctcctcacc ttcatcctct ttttctgggc ccctgtgcct cgggtcctgc aacacatctg    300

gatcctctgt gtggcagctg ccctttgggg tgtgggcagc gccctgaaca atactggact    360

cagcacactc ctgggaatct tgtacgaaga caaggagaga caggacttca tcttcaccat    420

ctaccactgg tggcaggctg tggccatctt caccgtgtac ctgggctcga gcctgcacat    480

gaaggctaag ctggcgatgc tgctggtgac gctggtggcg gccgcggtct cctacctgcg    540

gatggagcag aagctgcggc ggggcgtggc cccgcctcag ccccgcatcc cgcggcccca    600

gcacaaggtg cgcggttacc gctacttgga ggacaactcg gaggagagcg acgctgagga    660

cgagcatggg gacggcgcgg aggaggaggc gccgcccgcg gggcccaggc ctggccccga    720

gcccgctgga ctcggccgcc ggccctgccc gtacgaacag gcgcagaggg gagacggacc    780

ggaggagcag tgaggggccg cctggtcccc ggactcagcc tccctcctcg ccggcctcag    840

tttaccacgt cttaggtcgg ggggaccccc tctgagtccc gcgctgtatt caaaggcccc    900

tgtctcccct cccccacatt ggggacgccc ctcccagagc ccgggtcacc tccgggcttc    960

cgcagccccc tccaaggcgg agtggagcct tgggaacccc tcggccaagc acaggggttc   1020

gaaaatacag ctgaaaccct gcgggccctt agcacgcgcc ccagcgcggg agcagggtca   1080

gggtcttctt gcgacccggc cccgctccag atcctcccag ctgtcggccg cggacccggg   1140

ccgcgtgtga ccgcgctttg cacctcctat ccccagggtc cgccgagagc cacgattttt   1200

ttacagaaaa tgagcaataa agagattttg tac                                1233


<210>  5068
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  5068

Met Ala Gly Ala Gly Val His Leu Leu Leu Thr Phe Ile Leu Phe Phe 
1               5                   10                  15      


Trp Ala Pro Val Pro Arg Val Leu Gln His Ile Trp Ile Leu Cys Val 
            20                  25                  30          


Ala Ala Ala Leu Trp Gly Val Gly Ser Ala Leu Asn Asn Thr Gly Leu 
        35                  40                  45              


Ser Thr Leu Leu Gly Ile Leu Tyr Glu Asp Lys Glu Arg Gln Asp Phe 
    50                  55                  60                  


Ile Phe Thr Ile Tyr His Trp Trp Gln Ala Val Ala Ile Phe Thr Val 
65                  70                  75                  80  


Tyr Leu Gly Ser Ser Leu His Met Lys Ala Lys Leu Ala Met Leu Leu 
                85                  90                  95      


Val Thr Leu Val Ala Ala Ala Val Ser Tyr Leu Arg Met Glu Gln Lys 
            100                 105                 110         


Leu Arg Arg Gly Val Ala Pro Pro Gln Pro Arg Ile Pro Arg Pro Gln 
        115                 120                 125             


His Lys Val Arg Gly Tyr Arg Tyr Leu Glu Asp Asn Ser Glu Glu Ser 
    130                 135                 140                 


Asp Ala Glu Asp Glu His Gly Asp Gly Ala Glu Glu Glu Ala Pro Pro 
145                 150                 155                 160 


Ala Gly Pro Arg Pro Gly Pro Glu Pro Ala Gly Leu Gly Arg Arg Pro 
                165                 170                 175     


Cys Pro Tyr Glu Gln Ala Gln Arg Gly Asp Gly Pro Glu Glu Gln 
            180                 185                 190     


<210>  5069
<211>  327
<212>  DNA
<213>  Homosapiens

<400>  5069
atgggggtcc taagagccag gggggcaaga ggggctggag aggcgggtgc tattagtccc     60

cgcatcgcgg ggggcgcctc gcccccctgc gatttggatc gtaatatccg gggaggagag    120

gtgggtgcta ttagtccccg catcgcgggg ggcgcctcgc cccactgcga tttggatcgt    180

aatatccggg gaggagaggc gggtgctatt agtcccagca tcgcgggggg cgcctcgccc    240

cccttcgatt tggatcgtaa catccgggga ggagaggcgg gtgctattag ttcccgcatc    300

gcgcggggcg ccctcacccc cctgtga                                        327


<210>  5070
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  5070

Met Gly Val Leu Arg Ala Arg Gly Ala Arg Gly Ala Gly Glu Ala Gly 
1               5                   10                  15      


Ala Ile Ser Pro Arg Ile Ala Gly Gly Ala Ser Pro Pro Cys Asp Leu 
            20                  25                  30          


Asp Arg Asn Ile Arg Gly Gly Glu Val Gly Ala Ile Ser Pro Arg Ile 
        35                  40                  45              


Ala Gly Gly Ala Ser Pro His Cys Asp Leu Asp Arg Asn Ile Arg Gly 
    50                  55                  60                  


Gly Glu Ala Gly Ala Ile Ser Pro Ser Ile Ala Gly Gly Ala Ser Pro 
65                  70                  75                  80  


Pro Phe Asp Leu Asp Arg Asn Ile Arg Gly Gly Glu Ala Gly Ala Ile 
                85                  90                  95      


Ser Ser Arg Ile Ala Arg Gly Ala Leu Thr Pro Leu 
            100                 105             


<210>  5071
<211>  1631
<212>  DNA
<213>  Homosapiens

<400>  5071
atggcccagc ctgatgtccg catgcacctc tgcggcacac tggcctgcag acccccgagc     60

atatgctgca tgcttctcac ctctagagtg gccacccaga cagcgataca gacataccaa    120

gaaaacccac agcggctgaa gacagatgct gcccgattgc ctcggaagcc ctgtagacca    180

tcatggaccc cgagctttag ggctgtgacc atctatgaca agccggcatc tttctttaaa    240

gagacacctc tggacctgca gcaccggctc ttcatgaagc tgggcggcac gcactctccg    300

ttcagggccc gttcagaacc tgaggaacca gccacagagc cgtcggcctt catggagtgg    360

gatgctggga gcgggctggt gatgcttctc cgcgagcagc cagccctgct ggtcagcagc    420

acaggctgga cagaggatga agacttctcc atcctgctgg cagctttaga aaagtttgag    480

caactgactg ttgatggaca caaccttcct tctctcgtct gtgtgataac aggccaaggg    540

cctctgacgg agtattacag ccgccccatc caccagaagc atttccagca catccaggtc    600

tgcaaccctt ggctggaggc cgaggactac cccctgcttc tagggtcggt ggacctgggt    660

gtctgtctgc acacatcctc cagtggcctg gacctgccca tgaaggtggt ggacatgttc    720

gggtgctgtt tgcctgcgtg tgctgtgaac ttcaagtgtt tacatgagct ggtgaaacat    780

gaagaaaatg gcctggtctt tgaggactca gaggaactgg cagctcagct gcagatgctt    840

ttctcaaact ttcctgatcc tgcgggcaag ctaaaccagt tctggaagaa cctgcgggaa    900

tcgcagcagc tccgatggga tgagagctgg gtgcagagtg tgctccattt ggttatggac    960

acataactcc tgggccagag gctaaaaccc cgggacccct gctgtccttc ccgcagcttc   1020

ttctcggagt ctcagggcaa accctttcga gcagcgcctc ccagtggcca gaaggtgaaa   1080

tgacggcagt ggtgccgcct ggtgtcatct ttccgccgtg ttcctaacat tttgattcct   1140

gtcttgaaaa aagcacctgc tgcactgtaa gcccagggat gtggcagctg cagtgggctt   1200

ggctttgtga agaaccgagt tgtgtccaca ttgggggaac atcatacttg atacacacgt   1260

ttttatttgc acaaagaaaa tgctattttt ggagccagag atttcatgtc tgattgatgg   1320

cgattttctt aagaaccaga actgctggca gaaagggagc acccacatgc ttagatagct   1380

gatgtcttat tagagggcag tttgtggttc ctgatttgga aattaacatt ctccaaacat   1440

tccagtccaa tgaaagtttt atccgctttc ccatataaaa actcttccca ctagagtgac   1500

ttgattctca caatcccgtt ggagtcgtat gtgagtccta cagtgtgagg ttcagcattg   1560

ccatctccaa gtgctcttcg tagggaaaca gtttctggtc atgacgaggt tccacttccc   1620

atctgatccc a                                                        1631


<210>  5072
<211>  321
<212>  PRT
<213>  Homosapiens

<400>  5072

Met Ala Gln Pro Asp Val Arg Met His Leu Cys Gly Thr Leu Ala Cys 
1               5                   10                  15      


Arg Pro Pro Ser Ile Cys Cys Met Leu Leu Thr Ser Arg Val Ala Thr 
            20                  25                  30          


Gln Thr Ala Ile Gln Thr Tyr Gln Glu Asn Pro Gln Arg Leu Lys Thr 
        35                  40                  45              


Asp Ala Ala Arg Leu Pro Arg Lys Pro Cys Arg Pro Ser Trp Thr Pro 
    50                  55                  60                  


Ser Phe Arg Ala Val Thr Ile Tyr Asp Lys Pro Ala Ser Phe Phe Lys 
65                  70                  75                  80  


Glu Thr Pro Leu Asp Leu Gln His Arg Leu Phe Met Lys Leu Gly Gly 
                85                  90                  95      


Thr His Ser Pro Phe Arg Ala Arg Ser Glu Pro Glu Glu Pro Ala Thr 
            100                 105                 110         


Glu Pro Ser Ala Phe Met Glu Trp Asp Ala Gly Ser Gly Leu Val Met 
        115                 120                 125             


Leu Leu Arg Glu Gln Pro Ala Leu Leu Val Ser Ser Thr Gly Trp Thr 
    130                 135                 140                 


Glu Asp Glu Asp Phe Ser Ile Leu Leu Ala Ala Leu Glu Lys Phe Glu 
145                 150                 155                 160 


Gln Leu Thr Val Asp Gly His Asn Leu Pro Ser Leu Val Cys Val Ile 
                165                 170                 175     


Thr Gly Gln Gly Pro Leu Thr Glu Tyr Tyr Ser Arg Pro Ile His Gln 
            180                 185                 190         


Lys His Phe Gln His Ile Gln Val Cys Asn Pro Trp Leu Glu Ala Glu 
        195                 200                 205             


Asp Tyr Pro Leu Leu Leu Gly Ser Val Asp Leu Gly Val Cys Leu His 
    210                 215                 220                 


Thr Ser Ser Ser Gly Leu Asp Leu Pro Met Lys Val Val Asp Met Phe 
225                 230                 235                 240 


Gly Cys Cys Leu Pro Ala Cys Ala Val Asn Phe Lys Cys Leu His Glu 
                245                 250                 255     


Leu Val Lys His Glu Glu Asn Gly Leu Val Phe Glu Asp Ser Glu Glu 
            260                 265                 270         


Leu Ala Ala Gln Leu Gln Met Leu Phe Ser Asn Phe Pro Asp Pro Ala 
        275                 280                 285             


Gly Lys Leu Asn Gln Phe Trp Lys Asn Leu Arg Glu Ser Gln Gln Leu 
    290                 295                 300                 


Arg Trp Asp Glu Ser Trp Val Gln Ser Val Leu His Leu Val Met Asp 
305                 310                 315                 320 


Thr 
    


<210>  5073
<211>  1971
<212>  DNA
<213>  Homosapiens

<400>  5073
gccccgccca cgtcatggcg cccgaggaga acgcggggac cgaactcttg ctgcagagtt     60

tggagcgccg cttcctggcg gcgcgtgcac tgcgctcctt cccctggcag agcttagaag    120

caaagttaag agactcatca gattctgagc tgctgcggga tattttgcag aagacgtgct    180

gtatagccca gaagccatcg tgtcgctggt cggggtcctg cggaggctgg ctgcctgccg    240

ggagcaccag cgggctcctc aagtctatgt ggcccttacc atctgcaacc cagagacgtg    300

ccagctgttc accactgagc tatgccgggc tgggatcaga tgggaagtgg aacctcgtca    360

tgaccagaaa ctgtttccct acgaagagca cttggagatg gcaatgctga acctcacact    420

gtaggactca catacgactc caacgggatt gtgagaatca agtcactcta gtgggaagag    480

tttttatatg ggaaagcgga taaaactttc attggactgg aatgtttgga gaatgttaat    540

ttccaaatca ggaaccacaa actgccctct aataagacat cagctatcta agcatgtggg    600

tgctcccttt ctgccagcag ttctggttct taagaaaatc gccatcaatc agacatgaaa    660

tctctggctc caaaaatagc attttctttg tgcaaataaa aacgtgtgta tcaagtatga    720

tgttccccca atgtggacac actcggttcc ccacaaagcc aagcccgctg cagctgccac    780

atccctggac acattcggtt cctcacaaag ccaagcccgc tgcagctgcc acatccgtgg    840

acacactcgg ttcttcacaa agccaagccc actgcagctg ccacatccct gggcttacag    900

tgcagcaggt gcttttttca agacaggaat caaaatgtta ggaacacggc ggaaagatga    960

cacctggaga gcaaacgcag gatgaggagt actgcagagg tcacacggaa gtcgcagaac   1020

agtaatccgc tagcaggggc atggggcgtg aagaacagaa gaagatagga agtgtttccg   1080

agcctccaga aaagaaatca gagccaagca cagcttcccg ggtcacagaa ccaattcatt   1140

taccaggcgg caccactgcc gtcatttcac cttctggcca ctgggaggcg ctgctcgaaa   1200

gggtttgccc tgagactccg agaagaagct gcgggaagga cagcaggggt cccggggttt   1260

tagcctctgg cccaggagtt atgtgtccat aaccaaatgg agcacactct gcacccagct   1320

ctcatcccat cggagctgct gcgattcccg caggttcttc cagaactggt ttagcttgcc   1380

cgcaggatca ggaaagtttg agaaaagcat ctgcaaaaaa ataaagagca gagcttaact   1440

catttcctgt ccccacccca tcccaggtca ccacctggct gaccccaggt ccccgaccca   1500

acaacaaacc ctcccaagtt cctaactccc tcacttggac tcgagactct tcacgcccca   1560

gcagcgctcc gcctccaact tgacatcacg ctttctgtcc cactttccca cacttcgtgc   1620

cctggagcac ctcccggcct ctacacgctg tatgttcccc tgcgagcacc ctcctcttgg   1680

cctctggcca agtcccaccc atctgtgggt aacaaggggg tgttggtgtt cttttcagcc   1740

ttgctaaact gtctgaatca aggatcacaa actacagcct gcaggccaaa tccagcccac   1800

agcctgtgtt tgtaaataaa gttttattgg aacaaagcca caccccttaa tcgaagatga   1860

tctgtggcta ctttcacacc acaacagagt accatggttc tgacagagac taggagacac   1920

agtctaaatg acttctgacc tggaccttta ctgaaaatcc tgccaatcat t            1971


<210>  5074
<211>  131
<212>  PRT
<213>  Homosapiens

<400>  5074

Met Ala Pro Glu Glu Asn Ala Gly Thr Glu Leu Leu Leu Gln Ser Leu 
1               5                   10                  15      


Glu Arg Arg Phe Leu Ala Ala Arg Ala Leu Arg Ser Phe Pro Trp Gln 
            20                  25                  30          


Ser Leu Glu Ala Lys Leu Arg Asp Ser Ser Asp Ser Glu Leu Leu Arg 
        35                  40                  45              


Asp Ile Leu Gln Lys Thr Cys Cys Ile Ala Gln Lys Pro Ser Cys Arg 
    50                  55                  60                  


Trp Ser Gly Ser Cys Gly Gly Trp Leu Pro Ala Gly Ser Thr Ser Gly 
65                  70                  75                  80  


Leu Leu Lys Ser Met Trp Pro Leu Pro Ser Ala Thr Gln Arg Arg Ala 
                85                  90                  95      


Ser Cys Ser Pro Leu Ser Tyr Ala Gly Leu Gly Ser Asp Gly Lys Trp 
            100                 105                 110         


Asn Leu Val Met Thr Arg Asn Cys Phe Pro Thr Lys Ser Thr Trp Arg 
        115                 120                 125             


Trp Gln Cys 
    130     


<210>  5075
<211>  1812
<212>  DNA
<213>  Homosapiens

<400>  5075
acgtcatggc gcccgaggag aacgcgggga ccgaactctt gctgcagagt ttggagcgcc     60

gcttcctggc ggcgcgtgca ctgcgctcct tcccctggca gagcttagaa gcaaagttaa    120

gagactcatc agattctgag ctgctgcggg atattttgca gaaggccggg ctgggatcag    180

atgggaagtg gaacctcgtc atgaccagaa actgtttccc tacgaagagc acttggagat    240

ggcaatgctg aacctcacac tgtaggactc acatacgact ccaacgggat tgtgagaatc    300

aagtcactct agtgggaaga gtttttatat gggaaagcgg ataaaacttt cattggactg    360

gaatgtttgg agaatgttaa tttccaaatc aggaaccaca aactgccctc taataagaca    420

tcagctatct aagcatgtgg gtgctccctt tctgccagca gttctggttc ttaagaaaat    480

cgccatcaat cagacatgaa atctctggct ccaaaaatag cattttcttt gtgcaaataa    540

aaacgtgtgt atcaagtatg atgttccccc aatgtggaca cactcggttc cccacaaagc    600

caagcccgct gcagctgcca catccctgga cacattcggt tcctcacaaa gccaagcccg    660

ctgcagctgc cacatccgtg gacacactcg gttcttcaca aagccaagcc cactgcagct    720

gccacatccc tgggcttaca gtgcagcagg tgcttttttc aagacaggaa tcaaaatgtt    780

aggaacacgg cggaaagatg acacctggag agcaaacgca ggatgaggag tactgcagag    840

gtcacacgga agtcgcagaa cagtaatccg ctagcagggg catggggcgt gaagaacaga    900

agaagatagg aagtgtttcc gagcctccag aaaagaaatc agagccaagc acagcttccc    960

gggtcacaga accaattcat ttaccaggcg gcaccactgc cgtcatttca ccttctggcc   1020

actgggaggc gctgctcgaa agggtttgcc ctgagactcc gagaagaagc tgcgggaagg   1080

acagcagggg tcccggggtt ttagcctctg gcccaggagt tatgtgtcca taaccaaatg   1140

gagcacactc tgcacccagc tctcatccca tcggagctgc tgcgattccc gcaggttctt   1200

ccagaactgg tttagcttgc ccgcaggatc aggaaagttt gagaaaagca tctgcaaaaa   1260

aataaagagc agagcttaac tcatttcctg tccccacccc atcccaggtc accacctggc   1320

tgaccccagg tccccgaccc aacaacaaac cctcccaagt tcctaactcc ctcacttgga   1380

ctcgagactc ttcacgcccc agcagcgctc cgcctccaac ttgacatcac gctttctgtc   1440

ccactttccc acacttcgtg ccctggagca cctcccggcc tctacacgct gtatgttccc   1500

ctgcgagcac cctcctcttg gcctctggcc aagtcccacc catctgtggg taacaagggg   1560

gtgttggtgt tcttttcagc cttgctaaac tgtctgaatc aaggatcaca aactacagcc   1620

tgcaggccaa atccagccca cagcctgtgt ttgtaaataa agttttattg gaacaaagcc   1680

acacccctta atcgaagatg atctgtggct actttcacac cacaacagag taccatggtt   1740

ctgacagaga ctaggagaca cagtctaaat gacttctgac ctggaccttt actgaaaatc   1800

ctgccaatca tt                                                       1812


<210>  5076
<211>  81
<212>  PRT
<213>  Homosapiens

<400>  5076

Met Ala Pro Glu Glu Asn Ala Gly Thr Glu Leu Leu Leu Gln Ser Leu 
1               5                   10                  15      


Glu Arg Arg Phe Leu Ala Ala Arg Ala Leu Arg Ser Phe Pro Trp Gln 
            20                  25                  30          


Ser Leu Glu Ala Lys Leu Arg Asp Ser Ser Asp Ser Glu Leu Leu Arg 
        35                  40                  45              


Asp Ile Leu Gln Lys Ala Gly Leu Gly Ser Asp Gly Lys Trp Asn Leu 
    50                  55                  60                  


Val Met Thr Arg Asn Cys Phe Pro Thr Lys Ser Thr Trp Arg Trp Gln 
65                  70                  75                  80  


Cys 
    


<210>  5077
<211>  1601
<212>  DNA
<213>  Homosapiens

<400>  5077
caggggagcc cccaagtgga gcatagtgta tccagaactg gtgggttctt ggtctcactg     60

acttcaagaa tgaagccacg gaccctcgcg aaatgaggct tctccccagg accagcattc    120

cacgaaggca gcccttctct agatggagaa aacagaacct gaaggcaccc gtttccctaa    180

actgctctcg ctcatgtgct tccgaggcga tcgattgggc agtgtcggtc tgcagctgct    240

aagccaagaa gatctgggaa ggagtcagtc agagagcctt gggctggagt tccaggggct    300

ctgggagtgg ctgccagttc tacaaggcct ggagctgata cgaaaaacct cccttctttc    360

ccaaatggtc cccagcttcc ccgttcactg aagaccctgc agtcaggaac agtcaggact    420

ttgcacccag ttgttgtgcg tgtttggccg acccttcctc ttgtgtgatt cgtggaccct    480

tagcattgca ttaccaggga gcttttggaa ttgaagactc tcagggctca cccggaagga    540

cctcctgggc cagaatctgc attttaacaa gatgcccagg atctgtagcc caggctggag    600

tgcagtggtg cgatccctgc tcactgcagc ctctacctcc tgggttcaag cgatcctccc    660

acctcagcct cccgagtagc tgagaccaca ggcatggttt ctcaaccagg gggtgatttt    720

gccccccaga gaacatgtgg ccatgtctgg agacaatttt ggttgttgca gctggaggag    780

gtggtgctac tggcagctaa tgggtagagg ccagtgatgc tgctaaacat cctacaattc    840

cgcggacaac tcccactaag acaaaataat gatccagccc caaaggtcaa tagtgctgaa    900

agtgagagac cctgattcca tcttagagat catccaagca cacttggcca aattgttttt    960

gctactgtcc catgaagaaa aggcagactc atgactgatg gcaacatcga tgggaatttt   1020

gtttacctct tctttgtgga ccttgggata cgatgactta ccatttgtgc aagttgtgca   1080

ttgcatacct ccagggggcg ccacccacat atttatgaaa atgccacccc agaaattgca   1140

cagtacatag tctacatggc aataagcagt tgctctggtt ttggggttgc cctgaggtgc   1200

tctggaactg ggaggaactt tatttctggc cattagaggc cctgagcatg acattgagta   1260

ccctttcaag aaaggagaaa tgttgaacag agaggacctc atttttataa ctcttgacca   1320

tcatctagtt acggagcatc cacttttcac ccctgggcca tatccatttg acggatgaaa   1380

aatcatcaaa ttataatatc atggcttata cttttgatag cttctgcctg gaacatggcg   1440

gtaacaactt ctcattttca attgattcac tggggggaga aaatatacac ggctgcccta   1500

agactttcta ttacatacca tttgtttgac ggaatttctt tagtttctgt agcataactt   1560

attctaactg gtcctcaatc actttgcaat aaaacctgag a                       1601


<210>  5078
<211>  82
<212>  PRT
<213>  Homosapiens

<400>  5078

Met Glu Lys Thr Glu Pro Glu Gly Thr Arg Phe Pro Lys Leu Leu Ser 
1               5                   10                  15      


Leu Met Cys Phe Arg Gly Asp Arg Leu Gly Ser Val Gly Leu Gln Leu 
            20                  25                  30          


Leu Ser Gln Glu Asp Leu Gly Arg Ser Gln Ser Glu Ser Leu Gly Leu 
        35                  40                  45              


Glu Phe Gln Gly Leu Trp Glu Trp Leu Pro Val Leu Gln Gly Leu Glu 
    50                  55                  60                  


Leu Ile Arg Lys Thr Ser Leu Leu Ser Gln Met Val Pro Ser Phe Pro 
65                  70                  75                  80  


Val His 
        


<210>  5079
<211>  2204
<212>  DNA
<213>  Homosapiens

<400>  5079
accccgcgcg gttccacgcc cctggccgcg gcccgggcgc tgcgctgctc gacgcggcgg     60

gcggcgggcg gggaccgggg gcgggggcgg cggcggcggc cgggagagcg gaggaggcgg    120

agcagggagc cgggagcggg ctggcccgcg ctcctcctgc tggctgggga ttttccagcc    180

tgggcgctga cgccgcggac ctccctgcga ccgtcgcgga ccatgggcga caaagggacc    240

cgagtgttca agaaggccag tccaaatgga aagctcaccg tctacctggg aaagcgggac    300

tttgtggacc acatcgacct cgtggaccct gtggatggtg tggtcctggt ggatcctgag    360

tatctcaaag agcggagagt ctatgtgacg ctgacctgcg ccttccgcta tggccgggag    420

gacctggatg tcctgggcct gacctttcgc aaggacctgt ttgtggccaa cgtacagtcg    480

ttcccaccgg cccccgagga caagaagccc ctgacgcggc tgcaggaacg cctcatcaag    540

aagctgggcg agcacgctta ccctttcacc tttgagatcc ctccaaacct tccatgttct    600

gtgacactgc agccggggcc cgaagacacg gggaaggctt gcggtgtgga ctatgaagtc    660

aaagccttct gcgcggagaa tttggaggag aagatccaca agcggaattc tgtgcgtctg    720

gtcatccgga aggttcagta tgccccagag aggcctggcc cccagcccac agccgagacc    780

accaggcagt tcctcatgtc ggacaagccc ttgcacctag aagcctctct ggataaggag    840

atctattacc atggagaacc catcagcgtc aacgtccacg tcaccaacaa caccaacaag    900

acggtgaaga agatcaagat ctcagtgcgc cagtatgcag acatctgcct tttcaacaca    960

gctcagtaca agtgccctgt tgccatggaa gaggctgatg acactgtggc acccagctcg   1020

acgttctgca aggtctacac actgaccccc ttcctagcca ataaccgaga gaagcggggc   1080

ctcgccttgg acgggaagct caagcacgaa gacacgaact tggcctctag caccctgttg   1140

agggaaggtg ccaaccgtga gatcctgggg atcattgttt cctacaaagt gaaagtgaag   1200

ctggtggtgt ctcggggcgg cctgttggga gatcttgcat ccagcgacgt ggccgtggaa   1260

ctgcccttca ccctaatgca ccccaagccc aaagaggaac ccccgcatcg ggaagttcca   1320

gagaacgaga cgccagtaga taccaatctc atagaacttg acacaaatga tgacgacatt   1380

gtatttgagg actttgctcg ccagagactg aaaggcatga aggatgacaa ggaggaagag   1440

gaggatggta ccggctctcc acagctcaac aacagataga cgggccggcc ctgcctccac   1500

gtggctccgg ctccactctc gtgcactcgg atgcttactc gtcttcttcc tgttctggtt   1560

tcttttcccc tttgttcttc cagtttctac cagggggccc cgtgggcttc cagatcacgg   1620

tgatgaacct ctggcctcag gattggcccc acatcaccac gccaacagga ccacagcgca   1680

ctggctccac cccatctctg ccatctccac tcccctcctt ttcatgctgt ctcccagaaa   1740

agctgccagg gctctggcct tggaattgga cttgagatgg ggagcagaca ggggaggatg   1800

gggaatgtgg gacacggtgt ggtgggcatg agggcttgga ggggtgggga tgagggctca   1860

agacacgaga gaagatgtcc acggtcccag gtggttaaca aagttctggc agctaaaaga   1920

tgaccgcgtt gaaggccacc tccttctggc tgggaggggc agaactgtgg acagattctc   1980

aatgcctttt tgaagttctg acccaccaaa gaccttctgc cttcaccctc ctccccacct   2040

gatgtccctc tgtgtctgat agtgatgttg gtgaaagttc gtagacccca ggagtagaga   2100

aaagcaactg gactgacttt cttaccagca gttacctaga ctgaggcaag ctgtgtggac   2160

tcacccaagt atatttcagt actgtcaggc tgtgacatct tagc                    2204


<210>  5080
<211>  418
<212>  PRT
<213>  Homosapiens

<400>  5080

Met Gly Asp Lys Gly Thr Arg Val Phe Lys Lys Ala Ser Pro Asn Gly 
1               5                   10                  15      


Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Ile Asp 
            20                  25                  30          


Leu Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu 
        35                  40                  45              


Lys Glu Arg Arg Val Tyr Val Thr Leu Thr Cys Ala Phe Arg Tyr Gly 
    50                  55                  60                  


Arg Glu Asp Leu Asp Val Leu Gly Leu Thr Phe Arg Lys Asp Leu Phe 
65                  70                  75                  80  


Val Ala Asn Val Gln Ser Phe Pro Pro Ala Pro Glu Asp Lys Lys Pro 
                85                  90                  95      


Leu Thr Arg Leu Gln Glu Arg Leu Ile Lys Lys Leu Gly Glu His Ala 
            100                 105                 110         


Tyr Pro Phe Thr Phe Glu Ile Pro Pro Asn Leu Pro Cys Ser Val Thr 
        115                 120                 125             


Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp Tyr 
    130                 135                 140                 


Glu Val Lys Ala Phe Cys Ala Glu Asn Leu Glu Glu Lys Ile His Lys 
145                 150                 155                 160 


Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Tyr Ala Pro Glu 
                165                 170                 175     


Arg Pro Gly Pro Gln Pro Thr Ala Glu Thr Thr Arg Gln Phe Leu Met 
            180                 185                 190         


Ser Asp Lys Pro Leu His Leu Glu Ala Ser Leu Asp Lys Glu Ile Tyr 
        195                 200                 205             


Tyr His Gly Glu Pro Ile Ser Val Asn Val His Val Thr Asn Asn Thr 
    210                 215                 220                 


Asn Lys Thr Val Lys Lys Ile Lys Ile Ser Val Arg Gln Tyr Ala Asp 
225                 230                 235                 240 


Ile Cys Leu Phe Asn Thr Ala Gln Tyr Lys Cys Pro Val Ala Met Glu 
                245                 250                 255     


Glu Ala Asp Asp Thr Val Ala Pro Ser Ser Thr Phe Cys Lys Val Tyr 
            260                 265                 270         


Thr Leu Thr Pro Phe Leu Ala Asn Asn Arg Glu Lys Arg Gly Leu Ala 
        275                 280                 285             


Leu Asp Gly Lys Leu Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr 
    290                 295                 300                 


Leu Leu Arg Glu Gly Ala Asn Arg Glu Ile Leu Gly Ile Ile Val Ser 
305                 310                 315                 320 


Tyr Lys Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Leu Leu Gly 
                325                 330                 335     


Asp Leu Ala Ser Ser Asp Val Ala Val Glu Leu Pro Phe Thr Leu Met 
            340                 345                 350         


His Pro Lys Pro Lys Glu Glu Pro Pro His Arg Glu Val Pro Glu Asn 
        355                 360                 365             


Glu Thr Pro Val Asp Thr Asn Leu Ile Glu Leu Asp Thr Asn Asp Asp 
    370                 375                 380                 


Asp Ile Val Phe Glu Asp Phe Ala Arg Gln Arg Leu Lys Gly Met Lys 
385                 390                 395                 400 


Asp Asp Lys Glu Glu Glu Glu Asp Gly Thr Gly Ser Pro Gln Leu Asn 
                405                 410                 415     


Asn Arg 
        


<210>  5081
<211>  2180
<212>  DNA
<213>  Homosapiens

<400>  5081
accccgcgcg gttccacgcc cctggccgcg gcccgggcgc tgcgctgctc gacgcggcgg     60

gcggcgggcg gggaccgggg gcgggggcgg cggcggcggc cgggagagcg gaggaggcgg    120

agcagggagc cgggagcggg ctggcccgcg ctcctcctgc tggctgggga ttttccagcc    180

tgggcgctga cgccgcggac ctccctgcga ccgtcgcgga ccatgggcga caaagggacc    240

cgagtgttca agaaggccag tccaaatgga aagctcaccg tctacctggg aaagcgggac    300

tttgtggacc acatcgacct cgtggaccct gtggatggtg tggtcctggt ggatcctgag    360

tatctcaaag agcggagagt ctatgtgacg ctgacctgcg ccttccgcta tggccgggag    420

gacctggatg tcctgggcct gacctttcgc aaggacctgt ttgtggccaa cgtacagtcg    480

ttcccaccgg cccccgagga caagaagccc ctgacgcggc tgcaggaacg cctcatcaag    540

aagctgggcg agcacgctta ccctttcacc tttgagatcc ctccaaacct tccatgttct    600

gtgacactgc agccggggcc cgaagacacg gggaaggctt gcggtgtgga ctatgaagtc    660

aaagccttct gcgcggagaa tttggaggag aagatccaca agcggaattc tgtgcgtctg    720

gtcatccgga aggttcagta tgccccagag aggcctggcc cccagcccac agccgagacc    780

accaggcagt tcctcatgtc ggacaagccc ttgcacctag aagcctctct ggataaggag    840

atctattacc atggagaacc catcagcgtc aacgtccacg tcaccaacaa caccaacaag    900

acggtgaaga agatcaagat ctcagtgcgc cagtatgcag acatctgcct tttcaacaca    960

gctcagtaca agtgccctgt tgccatggaa gaggctgatg acactgtggc acccagctcg   1020

acgttctgca aggtctacac actgaccccc ttcctagcca ataaccgaga gaagcggggc   1080

ctcgccttgg acgggaagct caagcacgaa gacacgaact tggcctctag caccctgttg   1140

agggaaggtg ccaaccgtga gatcctgggg atcattgttt cctacaaagt gaaagtgaag   1200

ctggtggtgt ctcggggcgg cgacgtggcc gtggaactgc ccttcaccct aatgcacccc   1260

aagcccaaag aggaaccccc gcatcgggaa gttccagaga acgagacgcc agtagatacc   1320

aatctcatag aacttgacac aaatgatgac gacattgtat ttgaggactt tgctcgccag   1380

agactgaaag gcatgaagga tgacaaggag gaagaggagg atggtaccgg ctctccacag   1440

ctcaacaaca gatagacggg ccggccctgc ctccacgtgg ctccggctcc actctcgtgc   1500

actcggatgc ttactcgtct tcttcctgtt ctggtttctt ttcccctttg ttcttccagt   1560

ttctaccagg gggccccgtg ggcttccaga tcacggtgat gaacctctgg cctcaggatt   1620

ggccccacat caccacgcca acaggaccac agcgcactgg ctccacccca tctctgccat   1680

ctccactccc ctccttttca tgctgtctcc cagaaaagct gccagggctc tggccttgga   1740

attggacttg agatggggag cagacagggg aggatgggga atgtgggaca cggtgtggtg   1800

ggcatgaggg cttggagggg tggggatgag ggctcaagac acgagagaag atgtccacgg   1860

tcccaggtgg ttaacaaagt tctggcagct aaaagatgac cgcgttgaag gccacctcct   1920

tctggctggg aggggcagaa ctgtggacag attctcaatg cctttttgaa gttctgaccc   1980

accaaagacc ttctgccttc accctcctcc ccacctgatg tccctctgtg tctgatagtg   2040

atgttggtga aagttcgtag accccaggag tagagaaaag caactggact gactttctta   2100

ccagcagtta cctagactga ggcaagctgt gtggactcac ccaagtatat ttcagtactg   2160

tcaggctgtg acatcttagc                                               2180


<210>  5082
<211>  410
<212>  PRT
<213>  Homosapiens

<400>  5082

Met Gly Asp Lys Gly Thr Arg Val Phe Lys Lys Ala Ser Pro Asn Gly 
1               5                   10                  15      


Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Ile Asp 
            20                  25                  30          


Leu Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu 
        35                  40                  45              


Lys Glu Arg Arg Val Tyr Val Thr Leu Thr Cys Ala Phe Arg Tyr Gly 
    50                  55                  60                  


Arg Glu Asp Leu Asp Val Leu Gly Leu Thr Phe Arg Lys Asp Leu Phe 
65                  70                  75                  80  


Val Ala Asn Val Gln Ser Phe Pro Pro Ala Pro Glu Asp Lys Lys Pro 
                85                  90                  95      


Leu Thr Arg Leu Gln Glu Arg Leu Ile Lys Lys Leu Gly Glu His Ala 
            100                 105                 110         


Tyr Pro Phe Thr Phe Glu Ile Pro Pro Asn Leu Pro Cys Ser Val Thr 
        115                 120                 125             


Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp Tyr 
    130                 135                 140                 


Glu Val Lys Ala Phe Cys Ala Glu Asn Leu Glu Glu Lys Ile His Lys 
145                 150                 155                 160 


Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Tyr Ala Pro Glu 
                165                 170                 175     


Arg Pro Gly Pro Gln Pro Thr Ala Glu Thr Thr Arg Gln Phe Leu Met 
            180                 185                 190         


Ser Asp Lys Pro Leu His Leu Glu Ala Ser Leu Asp Lys Glu Ile Tyr 
        195                 200                 205             


Tyr His Gly Glu Pro Ile Ser Val Asn Val His Val Thr Asn Asn Thr 
    210                 215                 220                 


Asn Lys Thr Val Lys Lys Ile Lys Ile Ser Val Arg Gln Tyr Ala Asp 
225                 230                 235                 240 


Ile Cys Leu Phe Asn Thr Ala Gln Tyr Lys Cys Pro Val Ala Met Glu 
                245                 250                 255     


Glu Ala Asp Asp Thr Val Ala Pro Ser Ser Thr Phe Cys Lys Val Tyr 
            260                 265                 270         


Thr Leu Thr Pro Phe Leu Ala Asn Asn Arg Glu Lys Arg Gly Leu Ala 
        275                 280                 285             


Leu Asp Gly Lys Leu Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr 
    290                 295                 300                 


Leu Leu Arg Glu Gly Ala Asn Arg Glu Ile Leu Gly Ile Ile Val Ser 
305                 310                 315                 320 


Tyr Lys Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp Val Ala 
                325                 330                 335     


Val Glu Leu Pro Phe Thr Leu Met His Pro Lys Pro Lys Glu Glu Pro 
            340                 345                 350         


Pro His Arg Glu Val Pro Glu Asn Glu Thr Pro Val Asp Thr Asn Leu 
        355                 360                 365             


Ile Glu Leu Asp Thr Asn Asp Asp Asp Ile Val Phe Glu Asp Phe Ala 
    370                 375                 380                 


Arg Gln Arg Leu Lys Gly Met Lys Asp Asp Lys Glu Glu Glu Glu Asp 
385                 390                 395                 400 


Gly Thr Gly Ser Pro Gln Leu Asn Asn Arg 
                405                 410 


<210>  5083
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  5083
atgactgaca cagtgcctac atcattacat gcctgcaaag aaattcattt tccatctcct     60

ctcatcttca cgttccctgt aaaggaagaa aaggagaatg tcaagggctt gcagagatgg    120

aagtatgatg tgatggatat aattatggga cactgtgtgg gcacacggcc tcctgcttgt    180

tgcctcatcc tcctgctttt caagcttttg gccactgtct cccaggggct gccagggact    240

ggacccctgg gcttccactt cacacattcc atttataatg ctaccgtgta tgagaactca    300

gcagcaagga cctacgtcaa cagccagagt agaatgggca tcaccttaat agatctatcc    360

tgggatatca aatacagaat agtgtccgga gacgaggaag gctttttcaa agcagaggaa    420

gtcatcattg cagatttctg ttttctcaga ataagaacta aaggtggcaa ttctgccata    480

ttaaataggg aaatccagga taattattta ttgatagtaa aaggttctgt cagaggagag    540

gatttggaag catggaccaa agtgaatata caggttttag atatgaatga tctgagacct    600

ttgttttcac ccacaacata ctctgttacc atagcagaaa gcacacctct aaggactagt    660

gttgcccagg tgactgcaac agacgcagat attggttcca atggagaatt ctactactac    720

tttaaaaata aagttgatct cttttcagtt caccccacga gtggtgtcat ctccttaagt    780

ggtcgattaa attatgatga aaagaatagg tatgatctgg aaattttggc tgtggaccgg    840

ggaatgaaac tgtatgggaa caatggagtg agcagtactg caaagcttta tgttcacatt    900

gagcgcataa atgaacatgc cccaacaatc catgtagtca ctcatgttcc tttctcgttg    960

gaaaaagagc caacatatgc agtggtgaca gttgatgact tagatgatgg agcgaatgga   1020

gagatcgaat ctgtttccat tgtggctggg gatcctttag atcagttctt cctggctaag   1080

gaaggaaagt ggttgaatga gtacaagatt aaggagagga agcagattga ctgggagagc   1140

tttccctatg gctacaatct cactcttcaa gcaaaagaca agggatctcc tcaaaaatgt   1200

tcagcattaa aggcagtcta cattggcaac cccacaagag acactgtccc cattagattt   1260

gaaaaagaag tgtacgatgt gagcataagt gaattttccc ctcctggtgt cgtggttgct   1320

atagtaaaat taagtcctga accgatagat gtggaataca aattatctcc tggtgaggat   1380

gcagtgtact ttaaaattaa tcctcggtcg ggtctgattg ttacagcacg gccactgaat   1440

actgttaaga aggaggttta taaactggag gtgacaaaca aggaaggaga tttaaaagca   1500

caggtcacca tcagcataga agatgcaaat gaccacaccc cagaatttca gcaaccactg   1560

tatgatgctt atgtgaatga aagtgtccca gtgggaacca gcgttctaac agtttcagct   1620

tctgataagg ataaaggaga aaatgggtac atcacctata gtatcgctag cctgaatttg   1680

ttaccatttg tcattaatca gtttacaggt gttattagca caactgaaga actggatttt   1740

gaatcctccc cagaaattta cagattcatt gttagagcct ctgactgggg ttcaccatac   1800

cgccatgaaa gtgaggtcaa tgtgactatt cgaataggaa atgtcaacga caacagccct   1860

ctctttgaaa aagtggcttg ccagggagtt atttcatatg actttccagt tggtggtcac   1920

atcacagcag tctcagcgat cgatatcgat gaacttgaac ttgtaaagta caaaatcatt   1980

tctggaaatg aacttggctt cttttattta aacccagatt ctggtgtttt acagcttaaa   2040

aaatcactga caaattctgg cattaaaaat ggcaattttg ccctcagaat tacagcaact   2100

gatggagaga atcttgcaga ccccatgtct attaacattt cagtcctaca tgggaaagtg   2160

tcttcaaaga gcttcagttg cagagaaact cgtgtggctc aaaagctggc agagaaacta   2220

ctcattaagg caaaagcaaa tgggaaactg aatctggaag atggatttct tgacttttat   2280

tcaattaata gacagggacc atattttgac aagtcttttc cttctgatgt ggctgtaaag   2340

gaggatctgc cagttggtgc taacattctg aagattaaag cctatgatgc cgactctggc   2400

ttcaatggaa aagtgctatt tacaatatca gatggaaata cggatagttg ctttaatatt   2460

gatatggaga ctgggcagct taaagtcctt atgcccatgg atcgagaaca cacagacctc   2520

tatctcctta atatcaccat ctatgactta ggtaatccac agaaatcgtc atggagactg   2580

ctgaccatca atgtggagga tgctaatgac aatagcccag tttttattca agacagttac   2640

tcagttaaca ttcttgaaag ttcaggcatt ggtactgaaa tcattcaagt ggaagccaga   2700

gacaaagact taggttctaa tggtgaagtg acttactcag tcttgacaga tacacagcag   2760

tttgccatca atagctcaac tggaatcgtt tatgtagccg accagttgga ccgggaatcc   2820

aaagccaatt attctttgaa aatagaagcc agggacaagg cagagagtgg tcagcagctg   2880

ttttcagttg tcactcttaa agttttttta gatgatgtca atgactgctc cccagctttc   2940

attcccagta gctatagtgt gaaggttctt gaagatctcc ctgttggcac tgtcattgct   3000

tggcttgaga cccatgatcc agatcttgga ctggggggtc aagtgcgcta ttctttggtc   3060

aatgactata atgggagatt tgaaatagat aaagcaagtg gtgccatccg cttgagcaaa   3120

gagcttgatt atgagaaaca gcagttctat aaccttactg tgcgggccaa agacaaaggg   3180

cggcctgtct ctctgtcatc tgtttccttt gttgaggtgg aagtggtgga tgtcaatgaa   3240

aacctccaca ctccctattt cccagacttt gctgttgttg gatctgtaaa ggaaaactca   3300

cgcattggaa caagcgtgct gcaggtgact gctcgagatg aagactccgg aagggatgga   3360

gagatccagt actccatcag ggatggcagt ggtcttggaa ggttcagtat agacgacgag   3420

agtggggtca tcactgccgc agacattctt gatcgggaga caatggggtc atactggcta   3480

acagtgtatg ccacagacag gggcgttgtt ccactctact ccaccattga ggtctacatt   3540

gaagttgaag atgtgaatga caatgccccg ctgacctcag aacctatata ttatcctgtt   3600

gtcatggaaa actctccaaa ggacgtatct gtcattcaga tccaggctga agatcctgac   3660

tccagttcca atgaaaaact gacatacagg attacaagtg gaaatcctca gaattttttt   3720

gccatcaata tcaaaacagg tctgattaca acaacttcaa ggaaattgga tcgagaacag   3780

caggcagaac attttctgga ggtgactgtg acagatggtg gtccctctcc aaaacagtca   3840

accatttggg tggtggttca ggttctagat gaaaatgaca acaagcccca gttcccagag   3900

aaggtctacc agatcaagct gccagaacgt gaccgaaaga agagaggaga accgatttac   3960

agggcttttg catttgatag agatgagggc cccaacgcag aaatctccta cagtattgtg   4020

gatgggaatg atgacggaaa gttctttatt gaccctaaaa ctgggatggt ttcttctaga   4080

aagcagttta cagcaggcag ttatgacatc ctaacgataa aggcagtgga caatgggcgc   4140

ccacagaaat cctccacggc ccgcctccac attgaatgga ttaagaaacc acccccttca   4200

cctataccat tgaccttcga tgagccgttt tataacttca cagtcatgga aagtgataga   4260

gtgactgaaa ttgtaggggt ggtgtctgtg cagccagcta acacccctct gtggtttgac   4320

atagttgggg ggaattttga cagcgctttt gatgcagaga agggtgttgg gacaattgtc   4380

atcgcaaaac ctttggatgc agagcagagg tccatctata atatgagtgt ggaagtcacc   4440

gatgggacaa atgttgctgt tactcaggta tttatcaaag tgctggataa taatgataat   4500

ggcccagaat tctctcagcc gaattacgat gtgacaattt ccgaggatgt gcttccagac   4560

acggagatcc tgcagattga agccacagat agagatgaga agcacaagct gagctacact   4620

gttcatagca gcatcgactc catcagcatg agaaaattcc ggattgaccc tagcactggc   4680

gtgctctata ctgccgagag gctggaccat gaggcccagg acaagcacat tctcaacata   4740

atggtcagag atcaggagtt tccttatcga agaaacttgg cccgagtcat tgtgaatgtg   4800

gaggatgcta atgatcacag tccttatttt accaacccac tgtatgaagc gtctgtgttt   4860

gaatctgctg ctctgggatc agctgttctg caagtgacgg ctctggacaa agacaaagga   4920

gaaaatgcag aactcatata taccatagaa gcagggaaca ctgggaacat gtttaagatc   4980

gaaccggtcc taggcatcat caccatttgc aaagaaccag acatgacgac gatgggtcag   5040

tttgtcctat ccatcaaagt cacagatcag ggatccccgc caatgtctgc tactgcaatt   5100

gtgcgcattt ccgtcaccat gtctgacaat tctcacccca agttcattca caaagactac   5160

caagcagaag taaatgaaaa tgttgacatt ggaacatcag tcattctaat ctctgccatc   5220

agtcaatcta ccctcattta tgaagtcaaa gatggagaca ttaatgggat ctttaccata   5280

aatccatatt ctggagtcat caccactcag aaggccctgg attatgagcg cacatcctct   5340

tatcaactca tcattcaggc caccaatatg gcaggaatgg cttccaatgc tacagtcaat   5400

attcagattg ttgatgaaaa tgataatgcc ccagtttttc tcttttctca atactcaggc   5460

agcctaagtg aggctgcccc aattaatagc attgtcagga gcttggataa cagcccactg   5520

gtgattcgag ccacagatgc tgacagcaac cggaatgctc tgcttgtgta tcagattgtg   5580

gagtcaacag caaaaaagtt tttcacggtg gactccagta caggtgcaat cagaacaatt   5640

gccaacctgg accatgaaac cattgcccat ttccattttc atgtgcatgt gagagacagt   5700

ggtagccccc aactgactgc agagagtccc gttgaagtca acattgaggt gacagatgtg   5760

aatgataacc cacctgtttt tactcaggct gtgtttgaga ctatcttact tctacctacc   5820

tatgttggag tggaggttct gaaagttagt gccacagatc ctgactctga ggtaccccct   5880

gaactgacat acagcctaat ggaaggcagt ttggatcatt ttttaattga ctcaaacagt   5940

ggagtactta ccataaaaaa caacaacctc tccaaggatc actacatgct gatagttaag   6000

gtgtctgatg gaaagttcta cagtacctcc atggtcacca tcatggttaa agaagccatg   6060

gacagcggcc tccactttac acaaagcttc tattccacct caatctcaga gaacaacact   6120

aacataacca aagttgctat tgtcaatgca gttggaaatc gccttaatga gcccttaaaa   6180

tacagcatct taaacccagg aaataagttc aagataaaat ctacctcagg ggtcattcag   6240

acgactggag tcccctttga ccgtgaagaa caagagttat atgagctggt ggtagaagcc   6300

agccgtgagc tggaccatct gcgtgtggcc agagtggtgg tcagggttaa cattgaagac   6360

ataaatgaca attctccagt ctttgtgggc ctcccatact atgctgctgt tcaagtggat   6420

gcggaacccg ggactctgat ttatcaggtg acagccattg acaaagataa aggtccaaat   6480

ggagaagtga cctatgtcct gcaggatgac tatggccact ttgaaattaa ccctaattca   6540

gggaatgtta ttttaaagga agcattcaac tctgacttgt ccaacattga gtatggagtc   6600

accatcctag ccaaggatgg cggaaaacct tctttgtcta catctgtgga gcttcccatc   6660

actattgtca acaaagcaat gcctgtgttt gataagccct tttatacagc atctgtcaat   6720

gaagacatca gaatgaacac acccatccta agcatcaatg ccaccagtcc agaaggccaa   6780

ggcatcatat atatcattat cgatggggac ccttttaaac agtttaacat tgactttgac   6840

actggggtcc tgaaagttgt tagccctttg gattatgaag ttacatctgc ttacaagctg   6900

acaataagag ccagcgacgc ccttactggt gctagggctg aagtcactgt tgacttgcta   6960

gttaatgatg taaatgacaa cccccctatt ttcgatcagc ctacatacaa tacaacacta   7020

tcagaagcat ctcttattgg gacacctgtt ttacaagttg tctctattga tgcagactca   7080

gaaaacaata aaatggtaca ttatcagatt gtccaggata cctacaatag cacagattat   7140

tttcacatag atagctcaag tggcttaatc ctgacagcac gaatgctgga ccatgagtta   7200

gtacaacact gcactttgaa agtcagatca atagatagtg gcttcccatc actgagcagt   7260

gaggttctcg ttcatatcta catctctgat gtaaatgaca accctccagt ttttaatcag   7320

ctcatttatg agtcatatgt gagtgaatta gccccccggg gccattttgt aacctgtgta   7380

caagcctctg atgcagacag ctctgatttt gaccggttgg aatatagcat tttatctggg   7440

aatgaccgga cgagctttct gatggacagc aagagtggag ttatcacatt gtccaaccat   7500

cggaagcagc ggatggagcc tctgtacagt ctcaatgtgt ctgtctctga tgggttgttc   7560

accagcactg cacaggtgca tattagggta cttggggcta acttgtacag ccctgccttt   7620

tcacaaagca catacgtagc tgaggtgaga gagaacgtgg ctgcaggaac aaaggtaatt   7680

catgttcgag ccacagatgg tgatccaggg acttatgggc agatcagcta tgccatcatc   7740

aatgactttg ccaaggatcg attcctcata gacagcaatg ggcaggtcat caccacagaa   7800

aggctagacc gggaaaaccc tctagaaggg gatgttagta tttttgtgag ggcccttgat   7860

ggtggaggga gaacaacttt ctgcactgtg agagtgattg ttgtggatga aaatgacaat   7920

gctccccagt tcatgacagt ggaatataga gccagtgtca gggcagatgt tggaaggggc   7980

cacttggtca ctcaagttca agccatagat cccgatgatg gagcaaattc aaggattact   8040

tattccctct atagcgaggc ctctgtttca gtggccgacc tcctggaaat cgatcctgac   8100

aatggctgga tggtcacaaa gggtaatttt aaccagctga aaaatacagt gctttcgttc   8160

tttgtcaaag cagtagatgg gggcatccca gt                                 8192


<210>  5084
<211>  4601
<212>  PRT
<213>  Homosapiens

<400>  5084

Met Thr Asp Thr Val Pro Thr Ser Leu His Ala Cys Lys Glu Ile His 
1               5                   10                  15      


Phe Pro Ser Pro Leu Ile Phe Thr Phe Pro Val Lys Glu Glu Lys Glu 
            20                  25                  30          


Asn Val Lys Gly Leu Gln Arg Trp Lys Tyr Asp Val Met Asp Ile Ile 
        35                  40                  45              


Met Gly His Cys Val Gly Thr Arg Pro Pro Ala Cys Cys Leu Ile Leu 
    50                  55                  60                  


Leu Leu Phe Lys Leu Leu Ala Thr Val Ser Gln Gly Leu Pro Gly Thr 
65                  70                  75                  80  


Gly Pro Leu Gly Phe His Phe Thr His Ser Ile Tyr Asn Ala Thr Val 
                85                  90                  95      


Tyr Glu Asn Ser Ala Ala Arg Thr Tyr Val Asn Ser Gln Ser Arg Met 
            100                 105                 110         


Gly Ile Thr Leu Ile Asp Leu Ser Trp Asp Ile Lys Tyr Arg Ile Val 
        115                 120                 125             


Ser Gly Asp Glu Glu Gly Phe Phe Lys Ala Glu Glu Val Ile Ile Ala 
    130                 135                 140                 


Asp Phe Cys Phe Leu Arg Ile Arg Thr Lys Gly Gly Asn Ser Ala Ile 
145                 150                 155                 160 


Leu Asn Arg Glu Ile Gln Asp Asn Tyr Leu Leu Ile Val Lys Gly Ser 
                165                 170                 175     


Val Arg Gly Glu Asp Leu Glu Ala Trp Thr Lys Val Asn Ile Gln Val 
            180                 185                 190         


Leu Asp Met Asn Asp Leu Arg Pro Leu Phe Ser Pro Thr Thr Tyr Ser 
        195                 200                 205             


Val Thr Ile Ala Glu Ser Thr Pro Leu Arg Thr Ser Val Ala Gln Val 
    210                 215                 220                 


Thr Ala Thr Asp Ala Asp Ile Gly Ser Asn Gly Glu Phe Tyr Tyr Tyr 
225                 230                 235                 240 


Phe Lys Asn Lys Val Asp Leu Phe Ser Val His Pro Thr Ser Gly Val 
                245                 250                 255     


Ile Ser Leu Ser Gly Arg Leu Asn Tyr Asp Glu Lys Asn Arg Tyr Asp 
            260                 265                 270         


Leu Glu Ile Leu Ala Val Asp Arg Gly Met Lys Leu Tyr Gly Asn Asn 
        275                 280                 285             


Gly Val Ser Ser Thr Ala Lys Leu Tyr Val His Ile Glu Arg Ile Asn 
    290                 295                 300                 


Glu His Ala Pro Thr Ile His Val Val Thr His Val Pro Phe Ser Leu 
305                 310                 315                 320 


Glu Lys Glu Pro Thr Tyr Ala Val Val Thr Val Asp Asp Leu Asp Asp 
                325                 330                 335     


Gly Ala Asn Gly Glu Ile Glu Ser Val Ser Ile Val Ala Gly Asp Pro 
            340                 345                 350         


Leu Asp Gln Phe Phe Leu Ala Lys Glu Gly Lys Trp Leu Asn Glu Tyr 
        355                 360                 365             


Lys Ile Lys Glu Arg Lys Gln Ile Asp Trp Glu Ser Phe Pro Tyr Gly 
    370                 375                 380                 


Tyr Asn Leu Thr Leu Gln Ala Lys Asp Lys Gly Ser Pro Gln Lys Cys 
385                 390                 395                 400 


Ser Ala Leu Lys Ala Val Tyr Ile Gly Asn Pro Thr Arg Asp Thr Val 
                405                 410                 415     


Pro Ile Arg Phe Glu Lys Glu Val Tyr Asp Val Ser Ile Ser Glu Phe 
            420                 425                 430         


Ser Pro Pro Gly Val Val Val Ala Ile Val Lys Leu Ser Pro Glu Pro 
        435                 440                 445             


Ile Asp Val Glu Tyr Lys Leu Ser Pro Gly Glu Asp Ala Val Tyr Phe 
    450                 455                 460                 


Lys Ile Asn Pro Arg Ser Gly Leu Ile Val Thr Ala Arg Pro Leu Asn 
465                 470                 475                 480 


Thr Val Lys Lys Glu Val Tyr Lys Leu Glu Val Thr Asn Lys Glu Gly 
                485                 490                 495     


Asp Leu Lys Ala Gln Val Thr Ile Ser Ile Glu Asp Ala Asn Asp His 
            500                 505                 510         


Thr Pro Glu Phe Gln Gln Pro Leu Tyr Asp Ala Tyr Val Asn Glu Ser 
        515                 520                 525             


Val Pro Val Gly Thr Ser Val Leu Thr Val Ser Ala Ser Asp Lys Asp 
    530                 535                 540                 


Lys Gly Glu Asn Gly Tyr Ile Thr Tyr Ser Ile Ala Ser Leu Asn Leu 
545                 550                 555                 560 


Leu Pro Phe Val Ile Asn Gln Phe Thr Gly Val Ile Ser Thr Thr Glu 
                565                 570                 575     


Glu Leu Asp Phe Glu Ser Ser Pro Glu Ile Tyr Arg Phe Ile Val Arg 
            580                 585                 590         


Ala Ser Asp Trp Gly Ser Pro Tyr Arg His Glu Ser Glu Val Asn Val 
        595                 600                 605             


Thr Ile Arg Ile Gly Asn Val Asn Asp Asn Ser Pro Leu Phe Glu Lys 
    610                 615                 620                 


Val Ala Cys Gln Gly Val Ile Ser Tyr Asp Phe Pro Val Gly Gly His 
625                 630                 635                 640 


Ile Thr Ala Val Ser Ala Ile Asp Ile Asp Glu Leu Glu Leu Val Lys 
                645                 650                 655     


Tyr Lys Ile Ile Ser Gly Asn Glu Leu Gly Phe Phe Tyr Leu Asn Pro 
            660                 665                 670         


Asp Ser Gly Val Leu Gln Leu Lys Lys Ser Leu Thr Asn Ser Gly Ile 
        675                 680                 685             


Lys Asn Gly Asn Phe Ala Leu Arg Ile Thr Ala Thr Asp Gly Glu Asn 
    690                 695                 700                 


Leu Ala Asp Pro Met Ser Ile Asn Ile Ser Val Leu His Gly Lys Val 
705                 710                 715                 720 


Ser Ser Lys Ser Phe Ser Cys Arg Glu Thr Arg Val Ala Gln Lys Leu 
                725                 730                 735     


Ala Glu Lys Leu Leu Ile Lys Ala Lys Ala Asn Gly Lys Leu Asn Leu 
            740                 745                 750         


Glu Asp Gly Phe Leu Asp Phe Tyr Ser Ile Asn Arg Gln Gly Pro Tyr 
        755                 760                 765             


Phe Asp Lys Ser Phe Pro Ser Asp Val Ala Val Lys Glu Asp Leu Pro 
    770                 775                 780                 


Val Gly Ala Asn Ile Leu Lys Ile Lys Ala Tyr Asp Ala Asp Ser Gly 
785                 790                 795                 800 


Phe Asn Gly Lys Val Leu Phe Thr Ile Ser Asp Gly Asn Thr Asp Ser 
                805                 810                 815     


Cys Phe Asn Ile Asp Met Glu Thr Gly Gln Leu Lys Val Leu Met Pro 
            820                 825                 830         


Met Asp Arg Glu His Thr Asp Leu Tyr Leu Leu Asn Ile Thr Ile Tyr 
        835                 840                 845             


Asp Leu Gly Asn Pro Gln Lys Ser Ser Trp Arg Leu Leu Thr Ile Asn 
    850                 855                 860                 


Val Glu Asp Ala Asn Asp Asn Ser Pro Val Phe Ile Gln Asp Ser Tyr 
865                 870                 875                 880 


Ser Val Asn Ile Leu Glu Ser Ser Gly Ile Gly Thr Glu Ile Ile Gln 
                885                 890                 895     


Val Glu Ala Arg Asp Lys Asp Leu Gly Ser Asn Gly Glu Val Thr Tyr 
            900                 905                 910         


Ser Val Leu Thr Asp Thr Gln Gln Phe Ala Ile Asn Ser Ser Thr Gly 
        915                 920                 925             


Ile Val Tyr Val Ala Asp Gln Leu Asp Arg Glu Ser Lys Ala Asn Tyr 
    930                 935                 940                 


Ser Leu Lys Ile Glu Ala Arg Asp Lys Ala Glu Ser Gly Gln Gln Leu 
945                 950                 955                 960 


Phe Ser Val Val Thr Leu Lys Val Phe Leu Asp Asp Val Asn Asp Cys 
                965                 970                 975     


Ser Pro Ala Phe Ile Pro Ser Ser Tyr Ser Val Lys Val Leu Glu Asp 
            980                 985                 990         


Leu Pro Val Gly Thr Val Ile Ala  Trp Leu Glu Thr His  Asp Pro Asp 
        995                 1000                 1005             


Leu Gly  Leu Gly Gly Gln Val  Arg Tyr Ser Leu Val  Asn Asp Tyr 
    1010                 1015                 1020             


Asn Gly  Arg Phe Glu Ile Asp  Lys Ala Ser Gly Ala  Ile Arg Leu 
    1025                 1030                 1035             


Ser Lys  Glu Leu Asp Tyr Glu  Lys Gln Gln Phe Tyr  Asn Leu Thr 
    1040                 1045                 1050             


Val Arg  Ala Lys Asp Lys Gly  Arg Pro Val Ser Leu  Ser Ser Val 
    1055                 1060                 1065             


Ser Phe  Val Glu Val Glu Val  Val Asp Val Asn Glu  Asn Leu His 
    1070                 1075                 1080             


Thr Pro  Tyr Phe Pro Asp Phe  Ala Val Val Gly Ser  Val Lys Glu 
    1085                 1090                 1095             


Asn Ser  Arg Ile Gly Thr Ser  Val Leu Gln Val Thr  Ala Arg Asp 
    1100                 1105                 1110             


Glu Asp  Ser Gly Arg Asp Gly  Glu Ile Gln Tyr Ser  Ile Arg Asp 
    1115                 1120                 1125             


Gly Ser  Gly Leu Gly Arg Phe  Ser Ile Asp Asp Glu  Ser Gly Val 
    1130                 1135                 1140             


Ile Thr  Ala Ala Asp Ile Leu  Asp Arg Glu Thr Met  Gly Ser Tyr 
    1145                 1150                 1155             


Trp Leu  Thr Val Tyr Ala Thr  Asp Arg Gly Val Val  Pro Leu Tyr 
    1160                 1165                 1170             


Ser Thr  Ile Glu Val Tyr Ile  Glu Val Glu Asp Val  Asn Asp Asn 
    1175                 1180                 1185             


Ala Pro  Leu Thr Ser Glu Pro  Ile Tyr Tyr Pro Val  Val Met Glu 
    1190                 1195                 1200             


Asn Ser  Pro Lys Asp Val Ser  Val Ile Gln Ile Gln  Ala Glu Asp 
    1205                 1210                 1215             


Pro Asp  Ser Ser Ser Asn Glu  Lys Leu Thr Tyr Arg  Ile Thr Ser 
    1220                 1225                 1230             


Gly Asn  Pro Gln Asn Phe Phe  Ala Ile Asn Ile Lys  Thr Gly Leu 
    1235                 1240                 1245             


Ile Thr  Thr Thr Ser Arg Lys  Leu Asp Arg Glu Gln  Gln Ala Glu 
    1250                 1255                 1260             


His Phe  Leu Glu Val Thr Val  Thr Asp Gly Gly Pro  Ser Pro Lys 
    1265                 1270                 1275             


Gln Ser  Thr Ile Trp Val Val  Val Gln Val Leu Asp  Glu Asn Asp 
    1280                 1285                 1290             


Asn Lys  Pro Gln Phe Pro Glu  Lys Val Tyr Gln Ile  Lys Leu Pro 
    1295                 1300                 1305             


Glu Arg  Asp Arg Lys Lys Arg  Gly Glu Pro Ile Tyr  Arg Ala Phe 
    1310                 1315                 1320             


Ala Phe  Asp Arg Asp Glu Gly  Pro Asn Ala Glu Ile  Ser Tyr Ser 
    1325                 1330                 1335             


Ile Val  Asp Gly Asn Asp Asp  Gly Lys Phe Phe Ile  Asp Pro Lys 
    1340                 1345                 1350             


Thr Gly  Met Val Ser Ser Arg  Lys Gln Phe Thr Ala  Gly Ser Tyr 
    1355                 1360                 1365             


Asp Ile  Leu Thr Ile Lys Ala  Val Asp Asn Gly Arg  Pro Gln Lys 
    1370                 1375                 1380             


Ser Ser  Thr Ala Arg Leu His  Ile Glu Trp Ile Lys  Lys Pro Pro 
    1385                 1390                 1395             


Pro Ser  Pro Ile Pro Leu Thr  Phe Asp Glu Pro Phe  Tyr Asn Phe 
    1400                 1405                 1410             


Thr Val  Met Glu Ser Asp Arg  Val Thr Glu Ile Val  Gly Val Val 
    1415                 1420                 1425             


Ser Val  Gln Pro Ala Asn Thr  Pro Leu Trp Phe Asp  Ile Val Gly 
    1430                 1435                 1440             


Gly Asn  Phe Asp Ser Ala Phe  Asp Ala Glu Lys Gly  Val Gly Thr 
    1445                 1450                 1455             


Ile Val  Ile Ala Lys Pro Leu  Asp Ala Glu Gln Arg  Ser Ile Tyr 
    1460                 1465                 1470             


Asn Met  Ser Val Glu Val Thr  Asp Gly Thr Asn Val  Ala Val Thr 
    1475                 1480                 1485             


Gln Val  Phe Ile Lys Val Leu  Asp Asn Asn Asp Asn  Gly Pro Glu 
    1490                 1495                 1500             


Phe Ser  Gln Pro Asn Tyr Asp  Val Thr Ile Ser Glu  Asp Val Leu 
    1505                 1510                 1515             


Pro Asp  Thr Glu Ile Leu Gln  Ile Glu Ala Thr Asp  Arg Asp Glu 
    1520                 1525                 1530             


Lys His  Lys Leu Ser Tyr Thr  Val His Ser Ser Ile  Asp Ser Ile 
    1535                 1540                 1545             


Ser Met  Arg Lys Phe Arg Ile  Asp Pro Ser Thr Gly  Val Leu Tyr 
    1550                 1555                 1560             


Thr Ala  Glu Arg Leu Asp His  Glu Ala Gln Asp Lys  His Ile Leu 
    1565                 1570                 1575             


Asn Ile  Met Val Arg Asp Gln  Glu Phe Pro Tyr Arg  Arg Asn Leu 
    1580                 1585                 1590             


Ala Arg  Val Ile Val Asn Val  Glu Asp Ala Asn Asp  His Ser Pro 
    1595                 1600                 1605             


Tyr Phe  Thr Asn Pro Leu Tyr  Glu Ala Ser Val Phe  Glu Ser Ala 
    1610                 1615                 1620             


Ala Leu  Gly Ser Ala Val Leu  Gln Val Thr Ala Leu  Asp Lys Asp 
    1625                 1630                 1635             


Lys Gly  Glu Asn Ala Glu Leu  Ile Tyr Thr Ile Glu  Ala Gly Asn 
    1640                 1645                 1650             


Thr Gly  Asn Met Phe Lys Ile  Glu Pro Val Leu Gly  Ile Ile Thr 
    1655                 1660                 1665             


Ile Cys  Lys Glu Pro Asp Met  Thr Thr Met Gly Gln  Phe Val Leu 
    1670                 1675                 1680             


Ser Ile  Lys Val Thr Asp Gln  Gly Ser Pro Pro Met  Ser Ala Thr 
    1685                 1690                 1695             


Ala Ile  Val Arg Ile Ser Val  Thr Met Ser Asp Asn  Ser His Pro 
    1700                 1705                 1710             


Lys Phe  Ile His Lys Asp Tyr  Gln Ala Glu Val Asn  Glu Asn Val 
    1715                 1720                 1725             


Asp Ile  Gly Thr Ser Val Ile  Leu Ile Ser Ala Ile  Ser Gln Ser 
    1730                 1735                 1740             


Thr Leu  Ile Tyr Glu Val Lys  Asp Gly Asp Ile Asn  Gly Ile Phe 
    1745                 1750                 1755             


Thr Ile  Asn Pro Tyr Ser Gly  Val Ile Thr Thr Gln  Lys Ala Leu 
    1760                 1765                 1770             


Asp Tyr  Glu Arg Thr Ser Ser  Tyr Gln Leu Ile Ile  Gln Ala Thr 
    1775                 1780                 1785             


Asn Met  Ala Gly Met Ala Ser  Asn Ala Thr Val Asn  Ile Gln Ile 
    1790                 1795                 1800             


Val Asp  Glu Asn Asp Asn Ala  Pro Val Phe Leu Phe  Ser Gln Tyr 
    1805                 1810                 1815             


Ser Gly  Ser Leu Ser Glu Ala  Ala Pro Ile Asn Ser  Ile Val Arg 
    1820                 1825                 1830             


Ser Leu  Asp Asn Ser Pro Leu  Val Ile Arg Ala Thr  Asp Ala Asp 
    1835                 1840                 1845             


Ser Asn  Arg Asn Ala Leu Leu  Val Tyr Gln Ile Val  Glu Ser Thr 
    1850                 1855                 1860             


Ala Lys  Lys Phe Phe Thr Val  Asp Ser Ser Thr Gly  Ala Ile Arg 
    1865                 1870                 1875             


Thr Ile  Ala Asn Leu Asp His  Glu Thr Ile Ala His  Phe His Phe 
    1880                 1885                 1890             


His Val  His Val Arg Asp Ser  Gly Ser Pro Gln Leu  Thr Ala Glu 
    1895                 1900                 1905             


Ser Pro  Val Glu Val Asn Ile  Glu Val Thr Asp Val  Asn Asp Asn 
    1910                 1915                 1920             


Pro Pro  Val Phe Thr Gln Ala  Val Phe Glu Thr Ile  Leu Leu Leu 
    1925                 1930                 1935             


Pro Thr  Tyr Val Gly Val Glu  Val Leu Lys Val Ser  Ala Thr Asp 
    1940                 1945                 1950             


Pro Asp  Ser Glu Val Pro Pro  Glu Leu Thr Tyr Ser  Leu Met Glu 
    1955                 1960                 1965             


Gly Ser  Leu Asp His Phe Leu  Ile Asp Ser Asn Ser  Gly Val Leu 
    1970                 1975                 1980             


Thr Ile  Lys Asn Asn Asn Leu  Ser Lys Asp His Tyr  Met Leu Ile 
    1985                 1990                 1995             


Val Lys  Val Ser Asp Gly Lys  Phe Tyr Ser Thr Ser  Met Val Thr 
    2000                 2005                 2010             


Ile Met  Val Lys Glu Ala Met  Asp Ser Gly Leu His  Phe Thr Gln 
    2015                 2020                 2025             


Ser Phe  Tyr Ser Thr Ser Ile  Ser Glu Asn Asn Thr  Asn Ile Thr 
    2030                 2035                 2040             


Lys Val  Ala Ile Val Asn Ala  Val Gly Asn Arg Leu  Asn Glu Pro 
    2045                 2050                 2055             


Leu Lys  Tyr Ser Ile Leu Asn  Pro Gly Asn Lys Phe  Lys Ile Lys 
    2060                 2065                 2070             


Ser Thr  Ser Gly Val Ile Gln  Thr Thr Gly Val Pro  Phe Asp Arg 
    2075                 2080                 2085             


Glu Glu  Gln Glu Leu Tyr Glu  Leu Val Val Glu Ala  Ser Arg Glu 
    2090                 2095                 2100             


Leu Asp  His Leu Arg Val Ala  Arg Val Val Val Arg  Val Asn Ile 
    2105                 2110                 2115             


Glu Asp  Ile Asn Asp Asn Ser  Pro Val Phe Val Gly  Leu Pro Tyr 
    2120                 2125                 2130             


Tyr Ala  Ala Val Gln Val Asp  Ala Glu Pro Gly Thr  Leu Ile Tyr 
    2135                 2140                 2145             


Gln Val  Thr Ala Ile Asp Lys  Asp Lys Gly Pro Asn  Gly Glu Val 
    2150                 2155                 2160             


Thr Tyr  Val Leu Gln Asp Asp  Tyr Gly His Phe Glu  Ile Asn Pro 
    2165                 2170                 2175             


Asn Ser  Gly Asn Val Ile Leu  Lys Glu Ala Phe Asn  Ser Asp Leu 
    2180                 2185                 2190             


Ser Asn  Ile Glu Tyr Gly Val  Thr Ile Leu Ala Lys  Asp Gly Gly 
    2195                 2200                 2205             


Lys Pro  Ser Leu Ser Thr Ser  Val Glu Leu Pro Ile  Thr Ile Val 
    2210                 2215                 2220             


Asn Lys  Ala Met Pro Val Phe  Asp Lys Pro Phe Tyr  Thr Ala Ser 
    2225                 2230                 2235             


Val Asn  Glu Asp Ile Arg Met  Asn Thr Pro Ile Leu  Ser Ile Asn 
    2240                 2245                 2250             


Ala Thr  Ser Pro Glu Gly Gln  Gly Ile Ile Tyr Ile  Ile Ile Asp 
    2255                 2260                 2265             


Gly Asp  Pro Phe Lys Gln Phe  Asn Ile Asp Phe Asp  Thr Gly Val 
    2270                 2275                 2280             


Leu Lys  Val Val Ser Pro Leu  Asp Tyr Glu Val Thr  Ser Ala Tyr 
    2285                 2290                 2295             


Lys Leu  Thr Ile Arg Ala Ser  Asp Ala Leu Thr Gly  Ala Arg Ala 
    2300                 2305                 2310             


Glu Val  Thr Val Asp Leu Leu  Val Asn Asp Val Asn  Asp Asn Pro 
    2315                 2320                 2325             


Pro Ile  Phe Asp Gln Pro Thr  Tyr Asn Thr Thr Leu  Ser Glu Ala 
    2330                 2335                 2340             


Ser Leu  Ile Gly Thr Pro Val  Leu Gln Val Val Ser  Ile Asp Ala 
    2345                 2350                 2355             


Asp Ser  Glu Asn Asn Lys Met  Val His Tyr Gln Ile  Val Gln Asp 
    2360                 2365                 2370             


Thr Tyr  Asn Ser Thr Asp Tyr  Phe His Ile Asp Ser  Ser Ser Gly 
    2375                 2380                 2385             


Leu Ile  Leu Thr Ala Arg Met  Leu Asp His Glu Leu  Val Gln His 
    2390                 2395                 2400             


Cys Thr  Leu Lys Val Arg Ser  Ile Asp Ser Gly Phe  Pro Ser Leu 
    2405                 2410                 2415             


Ser Ser  Glu Val Leu Val His  Ile Tyr Ile Ser Asp  Val Asn Asp 
    2420                 2425                 2430             


Asn Pro  Pro Val Phe Asn Gln  Leu Ile Tyr Glu Ser  Tyr Val Ser 
    2435                 2440                 2445             


Glu Leu  Ala Pro Arg Gly His  Phe Val Thr Cys Val  Gln Ala Ser 
    2450                 2455                 2460             


Asp Ala  Asp Ser Ser Asp Phe  Asp Arg Leu Glu Tyr  Ser Ile Leu 
    2465                 2470                 2475             


Ser Gly  Asn Asp Arg Thr Ser  Phe Leu Met Asp Ser  Lys Ser Gly 
    2480                 2485                 2490             


Val Ile  Thr Leu Ser Asn His  Arg Lys Gln Arg Met  Glu Pro Leu 
    2495                 2500                 2505             


Tyr Ser  Leu Asn Val Ser Val  Ser Asp Gly Leu Phe  Thr Ser Thr 
    2510                 2515                 2520             


Ala Gln  Val His Ile Arg Val  Leu Gly Ala Asn Leu  Tyr Ser Pro 
    2525                 2530                 2535             


Ala Phe  Ser Gln Ser Thr Tyr  Val Ala Glu Val Arg  Glu Asn Val 
    2540                 2545                 2550             


Ala Ala  Gly Thr Lys Val Ile  His Val Arg Ala Thr  Asp Gly Asp 
    2555                 2560                 2565             


Pro Gly  Thr Tyr Gly Gln Ile  Ser Tyr Ala Ile Ile  Asn Asp Phe 
    2570                 2575                 2580             


Ala Lys  Asp Arg Phe Leu Ile  Asp Ser Asn Gly Gln  Val Ile Thr 
    2585                 2590                 2595             


Thr Glu  Arg Leu Asp Arg Glu  Asn Pro Leu Glu Gly  Asp Val Ser 
    2600                 2605                 2610             


Ile Phe  Val Arg Ala Leu Asp  Gly Gly Gly Arg Thr  Thr Phe Cys 
    2615                 2620                 2625             


Thr Val  Arg Val Ile Val Val  Asp Glu Asn Asp Asn  Ala Pro Gln 
    2630                 2635                 2640             


Phe Met  Thr Val Glu Tyr Arg  Ala Ser Val Arg Ala  Asp Val Gly 
    2645                 2650                 2655             


Arg Gly  His Leu Val Thr Gln  Val Gln Ala Ile Asp  Pro Asp Asp 
    2660                 2665                 2670             


Gly Ala  Asn Ser Arg Ile Thr  Tyr Ser Leu Tyr Ser  Glu Ala Ser 
    2675                 2680                 2685             


Val Ser  Val Ala Asp Leu Leu  Glu Ile Asp Pro Asp  Asn Gly Trp 
    2690                 2695                 2700             


Met Val  Thr Lys Gly Asn Phe  Asn Gln Leu Lys Asn  Thr Val Leu 
    2705                 2710                 2715             


Ser Phe  Phe Val Lys Ala Val  Asp Gly Gly Ile Pro  Val Lys His 
    2720                 2725                 2730             


Ser Leu  Ile Pro Val Tyr Ile  His Val Leu Pro Pro  Glu Thr Phe 
    2735                 2740                 2745             


Leu Pro  Ser Phe Thr Gln Ser  Gln Tyr Ser Phe Thr  Ile Ala Glu 
    2750                 2755                 2760             


Asp Thr  Ala Ile Gly Ser Thr  Val Asp Thr Leu Arg  Ile Leu Pro 
    2765                 2770                 2775             


Ser Gln  Asn Val Trp Phe Ser  Thr Val Asn Gly Glu  Arg Pro Glu 
    2780                 2785                 2790             


Asn Asn  Lys Gly Gly Ile Phe  Val Ile Glu Gln Glu  Thr Gly Thr 
    2795                 2800                 2805             


Ile Lys  Leu Asp Lys Arg Leu  Asp Arg Glu Thr Ser  Pro Ala Phe 
    2810                 2815                 2820             


His Phe  Lys Val Ala Ala Thr  Ile Pro Leu Asp Lys  Val Asp Ile 
    2825                 2830                 2835             


Val Phe  Thr Val Asp Val Asp  Ile Lys Val Leu Asp  Leu Asn Asp 
    2840                 2845                 2850             


Asn Lys  Pro Val Phe Glu Thr  Ser Ser Tyr Asp Thr  Ile Ile Met 
    2855                 2860                 2865             


Glu Gly  Met Pro Val Gly Thr  Lys Leu Thr Gln Val  Arg Ala Ile 
    2870                 2875                 2880             


Asp Met  Asp Trp Gly Ala Asn  Gly Gln Val Thr Tyr  Ser Leu His 
    2885                 2890                 2895             


Ser Asp  Ser Gln Pro Glu Lys  Val Met Glu Ala Phe  Asn Ile Asp 
    2900                 2905                 2910             


Ser Asn  Thr Gly Trp Ile Ser  Thr Leu Lys Asp Leu  Asp His Glu 
    2915                 2920                 2925             


Thr Asp  Pro Thr Phe Thr Phe  Ser Val Val Ala Ser  Asp Leu Gly 
    2930                 2935                 2940             


Glu Ala  Phe Ser Leu Ser Ser  Thr Ala Leu Val Ser  Val Arg Val 
    2945                 2950                 2955             


Thr Asp  Ile Asn Asp Asn Ala  Pro Val Phe Ala Gln  Glu Val Tyr 
    2960                 2965                 2970             


Arg Gly  Asn Val Lys Glu Ser  Asp Pro Pro Gly Glu  Val Val Ala 
    2975                 2980                 2985             


Val Leu  Ser Thr Trp Asp Arg  Asp Thr Ser Asp Val  Asn Arg Gln 
    2990                 2995                 3000             


Val Ser  Tyr His Ile Thr Gly  Gly Asn Pro Arg Gly  Arg Phe Ala 
    3005                 3010                 3015             


Leu Gly  Leu Val Gln Ser Glu  Trp Lys Val Tyr Val  Lys Arg Pro 
    3020                 3025                 3030             


Leu Asp  Arg Glu Glu Gln Asp  Ile Tyr Phe Leu Asn  Ile Thr Ala 
    3035                 3040                 3045             


Thr Asp  Gly Leu Phe Val Thr  Gln Ala Met Val Glu  Val Ser Val 
    3050                 3055                 3060             


Ser Asp  Val Asn Asp Asn Ser  Pro Val Cys Asp Gln  Val Ala Tyr 
    3065                 3070                 3075             


Thr Ala  Leu Leu Pro Glu Asp  Ile Pro Ser Asn Lys  Ile Ile Leu 
    3080                 3085                 3090             


Lys Val  Ser Ala Lys Asp Ala  Asp Ile Gly Ser Asn  Gly Tyr Ile 
    3095                 3100                 3105             


Arg Tyr  Ser Leu Tyr Gly Ser  Gly Asn Ser Glu Phe  Phe Leu Asp 
    3110                 3115                 3120             


Pro Glu  Ser Gly Glu Leu Lys  Thr Leu Ala Leu Leu  Asp Arg Glu 
    3125                 3130                 3135             


Arg Ile  Pro Val Tyr Ser Leu  Met Ala Lys Ala Thr  Asp Gly Gly 
    3140                 3145                 3150             


Gly Arg  Phe Cys Gln Ser Asn  Ile His Leu Ile Leu  Glu Asp Val 
    3155                 3160                 3165             


Asn Asp  Asn Pro Pro Val Phe  Ser Ser Asp His Tyr  Asn Thr Cys 
    3170                 3175                 3180             


Val Tyr  Glu Asn Thr Ala Thr  Lys Ala Leu Leu Thr  Arg Val Gln 
    3185                 3190                 3195             


Ala Val  Asp Pro Asp Ile Gly  Ile Asn Arg Lys Val  Val Tyr Ser 
    3200                 3205                 3210             


Leu Ala  Asp Ser Ala Gly Gly  Val Phe Ser Ile Asp  Ser Ser Ser 
    3215                 3220                 3225             


Gly Ile  Ile Ile Leu Glu Gln  Pro Leu Asp Arg Glu  Gln Gln Ser 
    3230                 3235                 3240             


Ser Tyr  Asn Ile Ser Val Arg  Ala Thr Asp Gln Ser  Pro Gly Gln 
    3245                 3250                 3255             


Ser Leu  Ser Ser Leu Thr Thr  Val Thr Ile Thr Val  Leu Asp Ile 
    3260                 3265                 3270             


Asn Asp  Asn Pro Pro Val Phe  Glu Arg Arg Asp Tyr  Leu Val Thr 
    3275                 3280                 3285             


Val Pro  Glu Asp Thr Ser Pro  Gly Thr Gln Val Leu  Ala Val Phe 
    3290                 3295                 3300             


Ala Thr  Ser Lys Asp Ile Gly  Thr Asn Ala Glu Ile  Thr Tyr Leu 
    3305                 3310                 3315             


Ile Arg  Ser Gly Asn Glu Gln  Gly Lys Phe Lys Ile  Asn Pro Lys 
    3320                 3325                 3330             


Thr Gly  Gly Ile Ser Val Ser  Glu Val Leu Asp Tyr  Glu Leu Cys 
    3335                 3340                 3345             


Lys Arg  Phe Tyr Leu Val Val  Glu Ala Lys Asp Gly  Gly Thr Pro 
    3350                 3355                 3360             


Ala Leu  Ser Ala Val Ala Thr  Val Asn Ile Asn Leu  Thr Asp Val 
    3365                 3370                 3375             


Asn Asp  Asn Pro Pro Lys Phe  Ser Gln Asp Val Tyr  Ser Ala Val 
    3380                 3385                 3390             


Ile Ser  Glu Asp Ala Leu Val  Gly Asp Ser Val Ile  Leu Leu Ile 
    3395                 3400                 3405             


Ala Glu  Asp Val Asp Ser Gln  Pro Asn Gly Gln Ile  His Phe Ser 
    3410                 3415                 3420             


Ile Val  Asn Gly Asp Arg Asp  Asn Glu Phe Thr Val  Asp Pro Val 
    3425                 3430                 3435             


Leu Gly  Leu Val Lys Val Lys  Lys Lys Leu Asp Arg  Glu Arg Val 
    3440                 3445                 3450             


Ser Gly  Tyr Ser Leu Leu Val  Gln Ala Val Asp Ser  Gly Ile Pro 
    3455                 3460                 3465             


Ala Met  Ser Ser Thr Ala Thr  Val Asn Ile Asp Ile  Ser Asp Val 
    3470                 3475                 3480             


Asn Asp  Asn Ser Pro Val Phe  Thr Pro Ala Asn Tyr  Thr Ala Val 
    3485                 3490                 3495             


Ile Gln  Glu Asn Lys Pro Val  Gly Thr Ser Ile Leu  Gln Leu Val 
    3500                 3505                 3510             


Val Thr  Asp Arg Asp Ser Phe  His Asn Gly Pro Pro  Phe Ser Phe 
    3515                 3520                 3525             


Ser Ile  Leu Ser Gly Asn Glu  Glu Glu Glu Phe Val  Leu Asp Pro 
    3530                 3535                 3540             


His Gly  Ile Leu Arg Ser Ala  Val Val Phe Gln His  Thr Glu Ser 
    3545                 3550                 3555             


Leu Glu  Tyr Val Leu Cys Val  Gln Ala Lys Asp Ser  Gly Lys Pro 
    3560                 3565                 3570             


Gln Gln  Val Ser His Thr Tyr  Ile Arg Val Arg Val  Ile Glu Glu 
    3575                 3580                 3585             


Ser Thr  His Lys Pro Thr Ala  Ile Pro Leu Glu Ile  Phe Ile Val 
    3590                 3595                 3600             


Thr Met  Glu Asp Asp Phe Pro  Gly Gly Val Ile Gly  Lys Ile His 
    3605                 3610                 3615             


Ala Thr  Asp Gln Asp Met Tyr  Asp Val Leu Thr Phe  Ala Leu Lys 
    3620                 3625                 3630             


Ser Glu  Gln Lys Ser Leu Phe  Lys Val Asn Ser His  Asp Gly Lys 
    3635                 3640                 3645             


Ile Ile  Ala Leu Gly Gly Leu  Asp Ser Gly Lys Tyr  Val Leu Asn 
    3650                 3655                 3660             


Val Ser  Val Ser Asp Gly Arg  Phe Gln Val Pro Ile  Asp Val Val 
    3665                 3670                 3675             


Val His  Val Glu Gln Leu Val  His Glu Met Leu Gln  Asn Thr Val 
    3680                 3685                 3690             


Thr Ile  Arg Phe Glu Asn Val  Ser Pro Glu Asp Phe  Val Gly Leu 
    3695                 3700                 3705             


His Met  His Gly Phe Arg Arg  Thr Leu Arg Asn Ala  Val Leu Thr 
    3710                 3715                 3720             


Gln Lys  Gln Asp Ser Leu Arg  Ile Ile Ser Ile Gln  Pro Val Ala 
    3725                 3730                 3735             


Gly Thr  Asn Gln Leu Asp Met  Leu Phe Ala Val Glu  Met His Ser 
    3740                 3745                 3750             


Ser Glu  Phe Tyr Lys Pro Ala  Tyr Leu Ile Gln Lys  Leu Ser Asn 
    3755                 3760                 3765             


Ala Arg  Arg His Leu Glu Asn  Ile Met Arg Ile Ser  Ala Ile Leu 
    3770                 3775                 3780             


Glu Lys  Asn Cys Ser Gly Leu  Asp Cys Gln Glu Gln  His Cys Glu 
    3785                 3790                 3795             


Gln Gly  Leu Ser Leu Asp Ser  His Ala Leu Met Thr  Tyr Ser Thr 
    3800                 3805                 3810             


Ala Arg  Ile Ser Phe Val Cys  Pro Arg Phe Tyr Arg  Asn Val Arg 
    3815                 3820                 3825             


Cys Thr  Cys Asn Gly Gly Leu  Cys Pro Gly Ser Asn  Asp Pro Cys 
    3830                 3835                 3840             


Val Glu  Lys Pro Cys Pro Gly  Asp Met Gln Cys Val  Ser Tyr Glu 
    3845                 3850                 3855             


Ala Ser  Arg Arg Pro Phe Leu  Cys Gln Cys Pro Pro  Gly Lys Leu 
    3860                 3865                 3870             


Gly Glu  Cys Ser Gly His Thr  Ser Leu Ser Phe Ala  Gly Asn Ser 
    3875                 3880                 3885             


Tyr Ile  Lys Tyr Arg Leu Ser  Glu Asn Ser Lys Glu  Glu Asp Phe 
    3890                 3895                 3900             


Lys Leu  Ala Leu Arg Leu Arg  Thr Leu Gln Ser Asn  Gly Ile Ile 
    3905                 3910                 3915             


Met Tyr  Thr Arg Ala Asn Pro  Cys Ile Ile Leu Lys  Ile Val Asp 
    3920                 3925                 3930             


Gly Lys  Leu Trp Phe Gln Leu  Asp Cys Gly Ser Gly  Pro Gly Ile 
    3935                 3940                 3945             


Leu Gly  Ile Ser Gly Arg Ala  Val Asn Asp Gly Ser  Trp His Ser 
    3950                 3955                 3960             


Val Phe  Leu Glu Leu Asn Arg  Asn Phe Thr Ser Leu  Ser Leu Asp 
    3965                 3970                 3975             


Asp Ser  Tyr Val Glu Arg Arg  Arg Ala Pro Leu Tyr  Phe Gln Thr 
    3980                 3985                 3990             


Leu Ser  Thr Glu Ser Ser Ile  Tyr Phe Gly Ala Leu  Val Gln Ala 
    3995                 4000                 4005             


Asp Asn  Ile Arg Ser Leu Thr  Asp Thr Arg Val Thr  Gln Val Leu 
    4010                 4015                 4020             


Ser Gly  Phe Gln Gly Cys Leu  Asp Ser Val Ile Leu  Asn Asn Asn 
    4025                 4030                 4035             


Glu Leu  Pro Leu Gln Asn Lys  Arg Ser Ser Phe Ala  Glu Val Val 
    4040                 4045                 4050             


Gly Leu  Thr Glu Leu Lys Leu  Gly Cys Val Leu Tyr  Pro Asp Ala 
    4055                 4060                 4065             


Cys Lys  Arg Ser Pro Cys Gln  His Gly Gly Ser Cys  Thr Gly Leu 
    4070                 4075                 4080             


Pro Ser  Gly Gly Tyr Gln Cys  Thr Cys Leu Ser Gln  Phe Thr Gly 
    4085                 4090                 4095             


Arg Asn  Cys Glu Ser Glu Ile  Thr Ala Cys Phe Pro  Asn Pro Cys 
    4100                 4105                 4110             


Arg Asn  Gly Gly Ser Cys Asp  Pro Ile Gly Asn Thr  Phe Ile Cys 
    4115                 4120                 4125             


Asn Cys  Lys Ala Gly Leu Thr  Gly Val Thr Cys Glu  Glu Asp Ile 
    4130                 4135                 4140             


Asn Glu  Cys Glu Arg Glu Glu  Cys Glu Asn Gly Gly  Ser Cys Val 
    4145                 4150                 4155             


Asn Val  Phe Gly Ser Phe Leu  Cys Asn Cys Thr Pro  Gly Tyr Val 
    4160                 4165                 4170             


Gly Gln  Tyr Cys Gly Leu Arg  Pro Val Val Val Pro  Asn Ile Gln 
    4175                 4180                 4185             


Ala Gly  His Ser Tyr Val Gly  Lys Glu Glu Leu Ile  Gly Ile Ala 
    4190                 4195                 4200             


Val Val  Leu Phe Val Ile Phe  Ile Leu Val Val Leu  Phe Ile Val 
    4205                 4210                 4215             


Phe Arg  Lys Lys Val Phe Arg  Lys Asn Tyr Ser Arg  Asn Asn Ile 
    4220                 4225                 4230             


Thr Leu  Val Gln Asp Pro Ala  Thr Ala Ala Leu Leu  Asn Lys Ser 
    4235                 4240                 4245             


Asn Gly  Ile Pro Phe Arg Asn  Leu Arg Gly Ser Gly  Asp Gly Arg 
    4250                 4255                 4260             


Asn Val  Tyr Gln Glu Val Gly  Pro Pro Gln Val Pro  Val Arg Pro 
    4265                 4270                 4275             


Met Ala  Tyr Thr Pro Cys Phe  Gln Ser Asp Ser Arg  Ser Asn Leu 
    4280                 4285                 4290             


Asp Lys  Ile Val Asp Gly Leu  Gly Gly Glu His Gln  Glu Met Thr 
    4295                 4300                 4305             


Thr Phe  His Pro Glu Ser Pro  Arg Ile Leu Thr Ala  Arg Arg Gly 
    4310                 4315                 4320             


Val Val  Val Cys Ser Val Ala  Pro Asn Leu Pro Ala  Val Ser Pro 
    4325                 4330                 4335             


Cys Arg  Ser Asp Cys Asp Ser  Ile Arg Lys Asn Gly  Trp Asp Ala 
    4340                 4345                 4350             


Gly Thr  Glu Asn Lys Gly Val  Asp Asp Pro Gly Glu  Val Thr Cys 
    4355                 4360                 4365             


Phe Ala  Gly Ser Asn Lys Gly  Ser Asn Ser Glu Val  Gln Ser Leu 
    4370                 4375                 4380             


Ser Ser  Phe Gln Ser Asp Ser  Gly Asp Asp Asn Ala  Tyr His Trp 
    4385                 4390                 4395             


Asp Thr  Ser Asp Trp Met Pro  Gly Ala Arg Leu Ser  Asp Ile Glu 
    4400                 4405                 4410             


Glu Val  Pro Asn Tyr Glu Asn  Gln Asp Gly Gly Ser  Ala His Gln 
    4415                 4420                 4425             


Gly Ser  Thr Arg Glu Leu Glu  Ser Asp Tyr Tyr Leu  Gly Gly Tyr 
    4430                 4435                 4440             


Asp Ile  Asp Ser Glu Tyr Pro  Pro Pro His Glu Glu  Glu Phe Leu 
    4445                 4450                 4455             


Ser Gln  Asp Gln Leu Pro Pro  Pro Leu Pro Glu Asp  Phe Pro Asp 
    4460                 4465                 4470             


Gln Tyr  Glu Ala Leu Pro Pro  Ser Gln Pro Val Ser  Leu Ala Ser 
    4475                 4480                 4485             


Thr Leu  Ser Pro Asp Cys Arg  Arg Arg Pro Gln Phe  His Pro Ser 
    4490                 4495                 4500             


Gln Tyr  Leu Pro Pro His Pro  Phe Pro Asn Glu Thr  Asp Leu Val 
    4505                 4510                 4515             


Gly Pro  Pro Ala Ser Cys Glu  Phe Ser Thr Phe Ala  Val Ser Met 
    4520                 4525                 4530             


Asn Gln  Gly Thr Glu Pro Thr  Gly Pro Ala Asp Ser  Val Ser Leu 
    4535                 4540                 4545             


Ser Leu  His Asn Ser Arg Gly  Thr Ser Ser Ser Asp  Val Ser Ala 
    4550                 4555                 4560             


Asn Cys  Gly Phe Asp Asp Ser  Glu Val Ala Met Ser  Asp Tyr Glu 
    4565                 4570                 4575             


Ser Val  Gly Glu Leu Ser Leu  Ala Ser Leu His Ile  Pro Phe Val 
    4580                 4585                 4590             


Glu Thr  Gln His Gln Thr Gln  Val 
    4595                 4600     


<210>  5085
<211>  240
<212>  DNA
<213>  Homosapiens

<400>  5085
atgaccttcg tcattactga tgaaaatctt atgccagaac aagcttatga tgctgatgaa     60

gcattaccgt tttggcatta ttgccctgga actacactga gtagaactga tgatacagtt    120

cctacagaga ataaggatgc caaaggcaga ataactgagc tgggatgtgc taatgcagca    180

ggcacacata agtgtaaaca tactgtgata ggcaacagct tgcatcttca ctgtttttaa    240


<210>  5086
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  5086

Met Thr Phe Val Ile Thr Asp Glu Asn Leu Met Pro Glu Gln Ala Tyr 
1               5                   10                  15      


Asp Ala Asp Glu Ala Leu Pro Phe Trp His Tyr Cys Pro Gly Thr Thr 
            20                  25                  30          


Leu Ser Arg Thr Asp Asp Thr Val Pro Thr Glu Asn Lys Asp Ala Lys 
        35                  40                  45              


Gly Arg Ile Thr Glu Leu Gly Cys Ala Asn Ala Ala Gly Thr His Lys 
    50                  55                  60                  


Cys Lys His Thr Val Ile Gly Asn Ser Leu His Leu His Cys Phe 
65                  70                  75                  


<210>  5087
<211>  240
<212>  DNA
<213>  Homosapiens

<400>  5087
atgaccttcg tcattactga tgaaaatctt atgccagaac aagcttatga tgctgatgaa     60

gcattaccgt tttggcatta ttgccctgga actacactga gtagaactga tgatacagtt    120

cctacagaga ataaggatgc caaaggcaga ataactgagc tgggatgtgc taatgcagca    180

ggcacacata agtgtaaaca tactgtgata ggcaacagct tgcatcttca ctgtttttaa    240


<210>  5088
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  5088

Met Thr Phe Val Ile Thr Asp Glu Asn Leu Met Pro Glu Gln Ala Tyr 
1               5                   10                  15      


Asp Ala Asp Glu Ala Leu Pro Phe Trp His Tyr Cys Pro Gly Thr Thr 
            20                  25                  30          


Leu Ser Arg Thr Asp Asp Thr Val Pro Thr Glu Asn Lys Asp Ala Lys 
        35                  40                  45              


Gly Arg Ile Thr Glu Leu Gly Cys Ala Asn Ala Ala Gly Thr His Lys 
    50                  55                  60                  


Cys Lys His Thr Val Ile Gly Asn Ser Leu His Leu His Cys Phe 
65                  70                  75                  


<210>  5089
<211>  972
<212>  DNA
<213>  Homosapiens

<400>  5089
agacagagcc aaaatggaag gcgggacaag ggcggcctgg ctggggcgag gggctggtct     60

gggtccctgg gaaccccttg ccttgtgggc ttcggtctcc agggaggagc taggcagccg    120

ggctgcgggg ccgccggact gtggggtcct ccgcgcagcg agctgggagg agcggtcggc    180

tgggctgttg agctgcgcct cctccaactg ctgggaaact ccgcacttca atattggagc    240

atctctttcc cgggcaggaa aatacgctgc taacccccag tgggccgtag attggtacta    300

tcaattgagt ctgtcatttg gagagaccaa ttttgggcag gcatccaggc attgttctgc    360

atctctgcaa tgtatacgtt ttgtgccggt ggcttgacaa ccgtccttaa ctggtgctgc    420

caatatggtg gaaagcagga agaagaaata aatgtcttct ctgtaagaca tcactgtcaa    480

gaacactgaa agaagaaccc attaacgtag ggaacgttga ggactggaac aggttgtagg    540

gcgtcttcct acactttggg ttataacttc cattgcatca ccaccattta ccagtaaacc    600

agcacacaca gcaatcagta ctcgaaatgg ttctcttttg cagaaaaagc ctgcttttct    660

cccagctttg gtgagataga tacgtaatct tcgtaaagac ctataaggaa ttcctctgtg    720

gaacaaaatt ttaagcctcc agtacaggat gctgaaagaa gcaactcttt aatcttgcca    780

gcccatgcac agtgaagctg aagtgcttca atttacagat gttttacatt tagggaaggc    840

ttttccaaca aagacctacc gcagttacat cacaggctcc acctccgcct gccaggctgc    900

ttctgcaagg ctgttagtaa ggatactatg tattgctgtg cttgattaat gaagaaaata    960

aatctccaaa tc                                                        972


<210>  5090
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  5090

Met Glu Gly Gly Thr Arg Ala Ala Trp Leu Gly Arg Gly Ala Gly Leu 
1               5                   10                  15      


Gly Pro Trp Glu Pro Leu Ala Leu Trp Ala Ser Val Ser Arg Glu Glu 
            20                  25                  30          


Leu Gly Ser Arg Ala Ala Gly Pro Pro Asp Cys Gly Val Leu Arg Ala 
        35                  40                  45              


Ala Ser Trp Glu Glu Arg Ser Ala Gly Leu Leu Ser Cys Ala Ser Ser 
    50                  55                  60                  


Asn Cys Trp Glu Thr Pro His Phe Asn Ile Gly Ala Ser Leu Ser Arg 
65                  70                  75                  80  


Ala Gly Lys Tyr Ala Ala Asn Pro Gln Trp Ala Val Asp Trp Tyr Tyr 
                85                  90                  95      


Gln Leu Ser Leu Ser Phe Gly Glu Thr Asn Phe Gly Gln Ala Ser Arg 
            100                 105                 110         


His Cys Ser Ala Ser Leu Gln Cys Ile Arg Phe Val Pro Val Ala 
        115                 120                 125         


<210>  5091
<211>  811
<212>  DNA
<213>  Homosapiens

<400>  5091
acaaaccgtc aacagctggt ctcgcatgtc ctttgttccc ggtctgctct tgtgtttcgt     60

tctcctcctg tgtgttagcc ctgtgtacct tccctctcgt tcaccctcca catttcccat    120

ctctgagccc ctcagcttta tagggatgtc agcttggccc caatgtagtc ccatttacag    180

ccagactcct ggacttgcct atgagccatc ttcatttcca aaaaggcgat attgggtatg    240

tacattgcat gaaataaagt gggaatgtcc cagaagcaga aggacatctg atgcagtcca    300

cgccaataaa ttgggcttac ctttaaaaat catctgaata tgcaggtctt agggcagaga    360

atatagacag cttaagattt tctaaactac aagtcccacc caaaatacgg tattttcatg    420

atttcccaaa ggttgaccat cagcaagact ggatattttt cagacttaag atgactgttc    480

agtagctgat gttctggaaa aagatctggg ccttcaccat gaaatcttaa atgtgagcag    540

ttactggatg ttgaatttga aacctattca tttctttttt taaaacaagc ttggtcattt    600

ctgtgcaatg ctataattcg gaacgaaaca aagcacaatg ttaataaggt agacactaat    660

tcattcctct gaagagagat ctcttccaga cattttaagc cagggcaaga aatgtttaaa    720

gatgttttct gcagttgccg tagaaacact ccttagcagt catcttggct gttggtaaaa    780

aatgtggccg gtaccaaaaa aaaaaaaaaa a                                   811


<210>  5092
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  5092

Met Ser Phe Val Pro Gly Leu Leu Leu Cys Phe Val Leu Leu Leu Cys 
1               5                   10                  15      


Val Ser Pro Val Tyr Leu Pro Ser Arg Ser Pro Ser Thr Phe Pro Ile 
            20                  25                  30          


Ser Glu Pro Leu Ser Phe Ile Gly Met Ser Ala Trp Pro Gln Cys Ser 
        35                  40                  45              


Pro Ile Tyr Ser Gln Thr Pro Gly Leu Ala Tyr Glu Pro Ser Ser Phe 
    50                  55                  60                  


Pro Lys Arg Arg Tyr Trp Val Cys Thr Leu His Glu Ile Lys Trp Glu 
65                  70                  75                  80  


Cys Pro Arg Ser Arg Arg Thr Ser Asp Ala Val His Ala Asn Lys Leu 
                85                  90                  95      


Gly Leu Pro Leu Lys Ile Ile 
            100             


<210>  5093
<211>  811
<212>  DNA
<213>  Homosapiens

<400>  5093
acaaaccgtc aacagctggt ctcgcatgtc ctttgttccc ggtctgctct tgtgtttcgt     60

tctcctcctg tgtgttagcc ctgtgtacct tccctctcgt tcaccctcca catttcccat    120

ctctgagccc ctcagcttta tagggatgtc agcttggccc caatgtagtc ccatttacag    180

ccagactcct ggacttgcct atgagccatc ttcatttcca aaaaggcgat attgggtatg    240

tacattgcat gaaataaagt gggaatgtcc cagaagcaga aggacatctg atgcagtcca    300

cgccaataaa ttgggcttac ctttaaaaat catctgaata tgcaggtctt agggcagaga    360

atatagacag cttaagattt tctaaactac aagtcccacc caaaatacgg tattttcatg    420

atttcccaaa ggttgaccat cagcaagact ggatattttt cagacttaag atgactgttc    480

agtagctgat gttctggaaa aagatctggg ccttcaccat gaaatcttaa atgtgagcag    540

ttactggatg ttgaatttga aacctattca tttctttttt taaaacaagc ttggtcattt    600

ctgtgcaatg ctataattcg gaacgaaaca aagcacaatg ttaataaggt agacactaat    660

tcattcctct gaagagagat ctcttccaga cattttaagc cagggcaaga aatgtttaaa    720

gatgttttct gcagttgccg tagaaacact ccttagcagt catcttggct gttggtaaaa    780

aatgtggccg gtaccaaaaa aaaaaaaaaa a                                   811


<210>  5094
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  5094

Met Ser Phe Val Pro Gly Leu Leu Leu Cys Phe Val Leu Leu Leu Cys 
1               5                   10                  15      


Val Ser Pro Val Tyr Leu Pro Ser Arg Ser Pro Ser Thr Phe Pro Ile 
            20                  25                  30          


Ser Glu Pro Leu Ser Phe Ile Gly Met Ser Ala Trp Pro Gln Cys Ser 
        35                  40                  45              


Pro Ile Tyr Ser Gln Thr Pro Gly Leu Ala Tyr Glu Pro Ser Ser Phe 
    50                  55                  60                  


Pro Lys Arg Arg Tyr Trp Val Cys Thr Leu His Glu Ile Lys Trp Glu 
65                  70                  75                  80  


Cys Pro Arg Ser Arg Arg Thr Ser Asp Ala Val His Ala Asn Lys Leu 
                85                  90                  95      


Gly Leu Pro Leu Lys Ile Ile 
            100             


<210>  5095
<211>  690
<212>  DNA
<213>  Homosapiens

<400>  5095
atggcctgga gtttccgtgc aaaagtccag ctcggggggc tacttctctc cctccttggc     60

tgggtctgct cctgtgttac caccatcctg ccccagtgga agactcttaa tctggaactg    120

aacgagatgg agacctggat catggggatt tgggaggtct gcgtggatcg agaggaagtc    180

gccactgtgt gcaaggcctt tgaatccttc ttgtctctgc cccaggagct ccaggtagcc    240

cgcatcctca tggtagcctc ccatgggctg ggcctattgg ggcttttgct ctgcagcttt    300

gggtctgaat gcttccagtt tcacaggatc agatgggtat tcaagaggcg gcttggtctc    360

ctgggaagga ctttggaggc atccgcttca gccactaccc tccttccagt ctcctgggtg    420

gcccatgcca caatccaaga cttctgggat gacagcatcc ctgacatcat acctcggtgg    480

gagtttggag gtgccctcta cttgggctgg gctgctggta ttttcctggc tcttggtggg    540

ctactcctca tcttctcggc ctgcctggga aaagaagatg tgccttttcc tttgatggct    600

ggtcccacag tccccctatc ctgtgctcca gtggaggagt cagatggctc cttccacctc    660

atgctaagac ctaggaacct ggtcatctag                                     690


<210>  5096
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  5096

Met Ala Trp Ser Phe Arg Ala Lys Val Gln Leu Gly Gly Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Gly Trp Val Cys Ser Cys Val Thr Thr Ile Leu Pro Gln 
            20                  25                  30          


Trp Lys Thr Leu Asn Leu Glu Leu Asn Glu Met Glu Thr Trp Ile Met 
        35                  40                  45              


Gly Ile Trp Glu Val Cys Val Asp Arg Glu Glu Val Ala Thr Val Cys 
    50                  55                  60                  


Lys Ala Phe Glu Ser Phe Leu Ser Leu Pro Gln Glu Leu Gln Val Ala 
65                  70                  75                  80  


Arg Ile Leu Met Val Ala Ser His Gly Leu Gly Leu Leu Gly Leu Leu 
                85                  90                  95      


Leu Cys Ser Phe Gly Ser Glu Cys Phe Gln Phe His Arg Ile Arg Trp 
            100                 105                 110         


Val Phe Lys Arg Arg Leu Gly Leu Leu Gly Arg Thr Leu Glu Ala Ser 
        115                 120                 125             


Ala Ser Ala Thr Thr Leu Leu Pro Val Ser Trp Val Ala His Ala Thr 
    130                 135                 140                 


Ile Gln Asp Phe Trp Asp Asp Ser Ile Pro Asp Ile Ile Pro Arg Trp 
145                 150                 155                 160 


Glu Phe Gly Gly Ala Leu Tyr Leu Gly Trp Ala Ala Gly Ile Phe Leu 
                165                 170                 175     


Ala Leu Gly Gly Leu Leu Leu Ile Phe Ser Ala Cys Leu Gly Lys Glu 
            180                 185                 190         


Asp Val Pro Phe Pro Leu Met Ala Gly Pro Thr Val Pro Leu Ser Cys 
        195                 200                 205             


Ala Pro Val Glu Glu Ser Asp Gly Ser Phe His Leu Met Leu Arg Pro 
    210                 215                 220                 


Arg Asn Leu Val Ile 
225                 


<210>  5097
<211>  2794
<212>  DNA
<213>  Homosapiens

<400>  5097
cccactcccc caccccaccc tcacaccctc caccacccac tgtccccatg tctacctgac     60

tcctcaatcg ggatttggtg gaacctcctc ccaaaaaggc attagaaaga actgccaagc    120

acaaaatttt gttaagaaat ggcaactttt ggaacagaga ggctttctga ataaaaagaa    180

ccagccccct agcaagacac ccaagttgca ctcagaacct ccaaagaaag aggaaactcc    240

tagggtgcat ggcacttgga agacccctcc cttcccagaa aagaaggcag ctgcctccag    300

cagtgtgtca gaagagtccc tggacaggaa agctgcggtg tcatggctgt cccctgcccc    360

ttcaaagaat gctgattctg ttgcagctaa gtagatttgc tggaggtgcc cttctaaaga    420

ttaacagcca cccgacccac tcccagaaga aaggcctcca gaacaaatcc tctcagctca    480

gcgccccaca gaactctacc caagctcact cagaataaat gctttggagc atcccagaag    540

ttgccaagga agaatagtgg caattggctg tgagatgctg gacacaggac ccaaggggca    600

tgttactttc ttggttccat gtagcactgt cagctacagc ggagatgtgc ttcataacga    660

gtacatcctt ccccctggcc acactgtgga ctgccagacc aggtggagtg gtgtccagaa    720

gcagcacatg gtgaatgcca tgctcttcaa gattgctcat ggcatatatt gaagatacag    780

ggaagatggt ggtggacatg ccatccacaa tgacttcaaa gccccagtac tttcatccca    840

agtccctcac cagtgacaac tcccatatcc cccttctcct ccccaactgg aaggctgatt    900

gcccagtgaa cgtcaccatg tctttgaagc atctcatcaa gaatctgctg aattgggaca    960

tctgggttgg gaaaataggc attcctctgt ggaagacacc caggctacca tggagctata   1020

caaattggtt gaactcaagt gggaagaaca ccttgcccag aattccccga aagactggtg   1080

acaatgggga tgttggtgac gtggggaggc agaagcagca ccaggagaaa tagggcagtg   1140

gaccaatgga catctcaact agttccacat ctttggaagc taaaattgtt ggcaagagaa   1200

aggttctact ctagatttaa tatccattga aattccatct ctggtgttat gtcctgtgtc   1260

tggttaagtg tcccatggaa ggagggcgcc tccatgtcag aaccagccct gtgtctttta   1320

cctctttcat ggtgctatcc ctaggtccca gggtgcgctg tgccagtgaa gcgttttgaa   1380

tttcaaggga cagggcatac tgagaaatgt agtttcccaa agtgcctgat cactagagtg   1440

gctatatggc tcattttgtg cctcttcttc ttgagtaatt aacagcacct tctttcactc   1500

tcagaagtat cctggtttga taataaatta tatggtccca ttcctaacac aacctctgct   1560

tttggctcac agtctgcatc tagcctgttt caggacattg ctcattcttc ctacttgact   1620

gccagaggtg ccattgcagg tgaggtttag ttctcctttg ggttctaagg cagtggaggt   1680

aagacagtag cttggaagtc aacttttctg atttaggaaa gcagtctctt tcctaaggct   1740

atagaggatt tatttcatgt aggtcccagt tggtaggtta aaaaagaatt tgtaaagtgt   1800

ttctaactca tttatgctgg aggttgcaaa tttttttggt gaaaaataag accttggcaa   1860

tgaccttgag cagtaggata ttaaatttta actcccacaa gcttagcatt ccaataatgg   1920

aacactacgc ataaatgggt taatggtttt tagtctggcc gggcgcggtg gatcacttga   1980

ggtcaggagt tccagacccg cctgaccaac atggtgaaac cccgtctcta ctaaaaatac   2040

agaattagcc gagcgtggtg gcgcatgcct gtagtcctag ctactcggga ggctgaggca   2100

ggagaatcac ttgaaccggg gaggtggagg ttgcagtgag ccaagatcac gccattgcac   2160

cccagcctgg gcaacaagag caaaactctg tctcataaat aaataaataa ttgtttttag   2220

tctttatctt ggtaaaccaa gcccctaaaa attctaatta ttcccttgat acatttttat   2280

aatggaaaaa ataaaatgat tataaatttc agattttatt ttttaaggtt acacatatct   2340

gcttgtatat gtgtgacaca gtcctgggaa aatataaaag aaactgttaa tggataccat   2400

taggtagtag aactgagatg gaggtagatg acttttatgg tctgttttat acttttttgt   2460

atttgaattt tcgtaccagg tacatgcatt acttttacag tttaagaata aaaatgttgg   2520

ccaggcacag tggctcacac ctgtaatccc agcactttgg gaggctgagg tgggtggatc   2580

agttgagatc aggagttcga gaccagcttg gctgacacag caaaacccca tctctactaa   2640

aaatataaaa attagctggg cgtggcatcg cacacctgta gtcccagcta ctcgggaggc   2700

tgaggcagga caattgcttg aacccaggag gcagaggttg cagtaagccg agatcgtgcc   2760

gctgcactcc agcctgggtg acaaaatgag actc                               2794


<210>  5098
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  5098

Met Pro Cys Ser Ser Arg Leu Leu Met Ala Tyr Ile Glu Asp Thr Gly 
1               5                   10                  15      


Lys Met Val Val Asp Met Pro Ser Thr Met Thr Ser Lys Pro Gln Tyr 
            20                  25                  30          


Phe His Pro Lys Ser Leu Thr Ser Asp Asn Ser His Ile Pro Leu Leu 
        35                  40                  45              


Leu Pro Asn Trp Lys Ala Asp Cys Pro Val Asn Val Thr Met Ser Leu 
    50                  55                  60                  


Lys His Leu Ile Lys Asn Leu Leu Asn Trp Asp Ile Trp Val Gly Lys 
65                  70                  75                  80  


Ile Gly Ile Pro Leu Trp Lys Thr Pro Arg Leu Pro Trp Ser Tyr Thr 
                85                  90                  95      


Asn Trp Leu Asn Ser Ser Gly Lys Asn Thr Leu Pro Arg Ile Pro Arg 
            100                 105                 110         


Lys Thr Gly Asp Asn Gly Asp Val Gly Asp Val Gly Arg Gln Lys Gln 
        115                 120                 125             


His Gln Glu Lys 
    130         


<210>  5099
<211>  2794
<212>  DNA
<213>  Homosapiens

<400>  5099
cccactcccc caccccaccc tcacaccctc caccacccac tgtccccatg tctacctgac     60

tcctcaatcg ggatttggtg gaacctcctc ccaaaaaggc attagaaaga actgccaagc    120

acaaaatttt gttaagaaat ggcaactttt ggaacagaga ggctttctga ataaaaagaa    180

ccagccccct agcaagacac ccaagttgca ctcagaacct ccaaagaaag aggaaactcc    240

tagggtgcat ggcacttgga agacccctcc cttcccagaa aagaaggcag ctgcctccag    300

cagtgtgtca gaagagtccc tggacaggaa agctgcggtg tcatggctgt cccctgcccc    360

ttcaaagaat gctgattctg ttgcagctaa gtagatttgc tggaggtgcc cttctaaaga    420

ttaacagcca cccgacccac tcccagaaga aaggcctcca gaacaaatcc tctcagctca    480

gcgccccaca gaactctacc caagctcact cagaataaat gctttggagc atcccagaag    540

ttgccaagga agaatagtgg caattggctg tgagatgctg gacacaggac ccaaggggca    600

tgttactttc ttggttccat gtagcactgt cagctacagc ggagatgtgc ttcataacga    660

gtacatcctt ccccccggcc acactgtgga ctgccagacc aggtggagtg gtgtccagaa    720

gcagcacatg gtgaatgcca tgctcttcaa gattgctcat ggcatatatt gaagatacag    780

ggaagatggt ggtggacatg ccatccacaa tgacttcaaa gccccagtac tttcatccca    840

agtccctcac cagtgacaac tcccatatcc cccttctcct ccccaactgg aaggctgatt    900

gcccagtgaa cgtcaccatg tctttgaagc atctcatcaa gaatctgctg aattgggaca    960

tctgggttgg gaaaataggc attcctctgt ggaagacacc caggctacca tggagctata   1020

caaattggtt gaactcaagt gggaagaaca ccttgcccag aattccccga aagactggtg   1080

acaatgggga tgttggtgac gtggggaggc agaagcagca ccaggagaaa tagggcagtg   1140

gaccaatgga catctcaact agttccacat ctttggaagc taaaattgtt ggcaagagaa   1200

aggttctact ctagatttaa tatccattga aattccatct ctggtgttat gtcctgtgtc   1260

tggttaagtg tcccatggaa ggagggcgcc tccatgtcag aaccagccct gtgtctttta   1320

cctctttcat ggtgctatcc ctaggtccca gggtgcgctg tgccagtgaa gcgttttgaa   1380

tttcaaggga cagggcatac tgagaaatgt agtttcccaa agtgcctgat cactagagtg   1440

gctatatggc tcattttgtg cctcttcttc ttgagtaatt aacagcacct tctttcactc   1500

tcagaagtat cctggtttga taataaatta tatggtccca ttcctaacac aacctctgct   1560

tttggctcac agtctgcatc tagcctgttt caggacattg ctcattcttc ctacttgact   1620

gccagaggtg ccattgcagg tgaggtttag ttctcctttg ggttctaagg cagtggaggt   1680

aagacagtag cttggaagtc aacttttctg atttaggaaa gcagtctctt tcctaaggct   1740

atagaggatt tatttcatgt aggtcccagt tggtaggtta aaaaagaatt tgtaaagtgt   1800

ttctaactca tttatgctgg aggttgcaaa tttttttggt gaaaaataag accttggcaa   1860

tgaccttgag cagtaggata ttaaatttta actcccacaa gcttagcatt ccaataatgg   1920

aacactacgc ataaatgggt taatggtttt tagtctggcc gggcgcggtg gatcacttga   1980

ggtcaggagt tccagacccg cctgaccaac atggtgaaac cccgtctcta ctaaaaatac   2040

agaattagcc gagcgtggtg gcgcatgcct gtagtcctag ctactcggga ggctgaggca   2100

ggagaatcac ttgaaccggg gaggtggagg ttgcagtgag ccaagatcac gccattgcac   2160

cccagcctgg gcaacaagag caaaactctg tctcataaat aaataaataa ttgtttttag   2220

tctttatctt ggtaaaccaa gcccctaaaa attctaatta ttcccttgat acatttttat   2280

aatggaaaaa ataaaatgat tataaatttc agattttatt ttttaaggtt acacatatct   2340

gcttgtatat gtgtgacaca gtcctgggaa aatataaaag aaactgttaa tggataccat   2400

taggtagtag aactgagatg gaggtagatg acttttatgg tctgttttat acttttttgt   2460

atttgaattt tcgtaccagg tacatgcatt acttttacag tttaagaata aaaatgttgg   2520

ccaggcacag tggctcacac ctgtaatccc agcactttgg gaggctgagg tgggtggatc   2580

agttgagatc aggagttcga gaccagcttg gctgacacag caaaacccca tctctactaa   2640

aaatataaaa attagctggg cgtggcatcg cacacctgta gtcccagcta ctcgggaggc   2700

tgaggcagga caattgcttg aacccaggag gcagaggttg cagtaagccg agatcgtgcc   2760

gctgcactcc agcctgggtg acaaaatgag actc                               2794


<210>  5100
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  5100

Met Pro Cys Ser Ser Arg Leu Leu Met Ala Tyr Ile Glu Asp Thr Gly 
1               5                   10                  15      


Lys Met Val Val Asp Met Pro Ser Thr Met Thr Ser Lys Pro Gln Tyr 
            20                  25                  30          


Phe His Pro Lys Ser Leu Thr Ser Asp Asn Ser His Ile Pro Leu Leu 
        35                  40                  45              


Leu Pro Asn Trp Lys Ala Asp Cys Pro Val Asn Val Thr Met Ser Leu 
    50                  55                  60                  


Lys His Leu Ile Lys Asn Leu Leu Asn Trp Asp Ile Trp Val Gly Lys 
65                  70                  75                  80  


Ile Gly Ile Pro Leu Trp Lys Thr Pro Arg Leu Pro Trp Ser Tyr Thr 
                85                  90                  95      


Asn Trp Leu Asn Ser Ser Gly Lys Asn Thr Leu Pro Arg Ile Pro Arg 
            100                 105                 110         


Lys Thr Gly Asp Asn Gly Asp Val Gly Asp Val Gly Arg Gln Lys Gln 
        115                 120                 125             


His Gln Glu Lys 
    130         


<210>  5101
<211>  483
<212>  DNA
<213>  Homosapiens

<400>  5101
atgaggaggt tgcagagagg gctagaaaaa ggagtgaccg ccgtcctcct gaatcttgtt     60

gctttctggg tcaatccttc ctgttccttg tctactgctg acatctactg caggggaata    120

ggggactggg tgtccccacc cttccagcac ctctgcctag gacaggcttg tttgattcta    180

aaatccttta gaatagccag caagagtggt gacagaggtc aagcaaaagt tactcccatt    240

taccttgtcc ttcaggccat tgggcatccc tatttgcctc catactggtc tctgggattt    300

cagctgtgtc gatggggtta caatagccta gatatgctga aaaccacaga tgttcagtat    360

tgtgatatcg actgcatgga acgtcagatg gacttcatat atgatgagga caaatttgat    420

ggtctgcctg agtacattaa ggaactgaaa atgatggaat gcaatatatc attgttttgg    480

taa                                                                  483


<210>  5102
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  5102

Met Arg Arg Leu Gln Arg Gly Leu Glu Lys Gly Val Thr Ala Val Leu 
1               5                   10                  15      


Leu Asn Leu Val Ala Phe Trp Val Asn Pro Ser Cys Ser Leu Ser Thr 
            20                  25                  30          


Ala Asp Ile Tyr Cys Arg Gly Ile Gly Asp Trp Val Ser Pro Pro Phe 
        35                  40                  45              


Gln His Leu Cys Leu Gly Gln Ala Cys Leu Ile Leu Lys Ser Phe Arg 
    50                  55                  60                  


Ile Ala Ser Lys Ser Gly Asp Arg Gly Gln Ala Lys Val Thr Pro Ile 
65                  70                  75                  80  


Tyr Leu Val Leu Gln Ala Ile Gly His Pro Tyr Leu Pro Pro Tyr Trp 
                85                  90                  95      


Ser Leu Gly Phe Gln Leu Cys Arg Trp Gly Tyr Asn Ser Leu Asp Met 
            100                 105                 110         


Leu Lys Thr Thr Asp Val Gln Tyr Cys Asp Ile Asp Cys Met Glu Arg 
        115                 120                 125             


Gln Met Asp Phe Ile Tyr Asp Glu Asp Lys Phe Asp Gly Leu Pro Glu 
    130                 135                 140                 


Tyr Ile Lys Glu Leu Lys Met Met Glu Cys Asn Ile Ser Leu Phe Trp 
145                 150                 155                 160 


<210>  5103
<211>  387
<212>  DNA
<213>  Homosapiens

<400>  5103
atgcaaacct atgcagccag agctgatatc aaggaaactc ccctagaaaa tccagactgg     60

actctcttca cagatgagag ctctctcgta aatcaggcag ttcataaggc aaaatatgca    120

gtagtcactc taaataacat cattgaaagt gtgtgtctct ctccaggcac aagtgctcaa    180

ttagctgaac tgatagctct tacaagagca cttgaattaa gtaaggaaat ggtagctaac    240

atttacactg actccaagta tgctttctta gttctccatg ctcatgctgc catttggaag    300

aaaagacatc ttcttaccat taatggatcc cctataaaat accatcagga aattaacagg    360

ttattgtcat cagatttccc tccatga                                        387


<210>  5104
<211>  128
<212>  PRT
<213>  Homosapiens

<400>  5104

Met Gln Thr Tyr Ala Ala Arg Ala Asp Ile Lys Glu Thr Pro Leu Glu 
1               5                   10                  15      


Asn Pro Asp Trp Thr Leu Phe Thr Asp Glu Ser Ser Leu Val Asn Gln 
            20                  25                  30          


Ala Val His Lys Ala Lys Tyr Ala Val Val Thr Leu Asn Asn Ile Ile 
        35                  40                  45              


Glu Ser Val Cys Leu Ser Pro Gly Thr Ser Ala Gln Leu Ala Glu Leu 
    50                  55                  60                  


Ile Ala Leu Thr Arg Ala Leu Glu Leu Ser Lys Glu Met Val Ala Asn 
65                  70                  75                  80  


Ile Tyr Thr Asp Ser Lys Tyr Ala Phe Leu Val Leu His Ala His Ala 
                85                  90                  95      


Ala Ile Trp Lys Lys Arg His Leu Leu Thr Ile Asn Gly Ser Pro Ile 
            100                 105                 110         


Lys Tyr His Gln Glu Ile Asn Arg Leu Leu Ser Ser Asp Phe Pro Pro 
        115                 120                 125             


<210>  5105
<211>  1224
<212>  DNA
<213>  Homosapiens

<400>  5105
atgctacggt acattgctac gcttagacgc accaggaaag ctctggacga ggaagatgta     60

ggttgttgcc agcacctatg cacggacaga cagaaagtcc tctgcttcct tcaggccctt    120

gcttccactt ccccggggct tccagctgag cctgcatttt tctttgactt ccccctcttg    180

cctggcgttt tcagcaaaca cacacagagg attacgggga gaaaactatc atattaccaa    240

gtggacatgg ctcctaaggt gccaactgaa cacagcaaca gcgacgaggc ccgaggtgca    300

gctgtctcgc ctcgcctgtc ttttgcaggc accggcatgc acagaagatg gctctccggg    360

aggaagattc ctttccattt tgttctctct ctgcctccgc aaggctcgca gccacctctc    420

gggagtgcag ggccagatcc tgtgccagcg gccttacacg gccacagtcg gattcgctgc    480

cgcagcagcc gccaccccca ggagccgccg ggaccctcgc gtcgtcgccg ccgcggccca    540

gatccccaca ccatgccgtc ggagaagacc ttcaagcagc ggcgcacctt cgaacaaaga    600

gtagaagatg tccgacttat tcgagagcag catccaacca aaatcccggt gataatagaa    660

cgatacaagg gtgagaagca gcttcctgtt ctggataaaa caaagttcct tgtacctgac    720

catgtcaaca tgagtgagct catcaagata attagaaggc gcttacagct caatgctaat    780

caggccttct tcctgttggt gaacggacac agcatggtca gcgtctccac accaatctca    840

gaggtgtatg agagtgagaa agatgaagat ggattcctgt acatggtctg tgcctcccag    900

gagacgttcg ggatgaaatt gtcagtgtaa aaccagaaaa aatgcatctc ttctagaatt    960

ttttaaaccc ttaccaagga aaaaaaaagg gatgttacca actgagatcg atcagttcat   1020

ctaatcacag atcatcaaac agtagtgttc ccacctagga gtgttaggaa gttgtgtttg   1080

tgtttcaagc agaaaaactg agctccaagt gagcacattc agctttggaa actatattat   1140

ttaatgtagg ctagcttgtt ttcaaatttt aaaagtttaa aaataaaata ctttgcattc   1200

taaaaaaaaa aaaaaattgc ctta                                          1224


<210>  5106
<211>  309
<212>  PRT
<213>  Homosapiens

<400>  5106

Met Leu Arg Tyr Ile Ala Thr Leu Arg Arg Thr Arg Lys Ala Leu Asp 
1               5                   10                  15      


Glu Glu Asp Val Gly Cys Cys Gln His Leu Cys Thr Asp Arg Gln Lys 
            20                  25                  30          


Val Leu Cys Phe Leu Gln Ala Leu Ala Ser Thr Ser Pro Gly Leu Pro 
        35                  40                  45              


Ala Glu Pro Ala Phe Phe Phe Asp Phe Pro Leu Leu Pro Gly Val Phe 
    50                  55                  60                  


Ser Lys His Thr Gln Arg Ile Thr Gly Arg Lys Leu Ser Tyr Tyr Gln 
65                  70                  75                  80  


Val Asp Met Ala Pro Lys Val Pro Thr Glu His Ser Asn Ser Asp Glu 
                85                  90                  95      


Ala Arg Gly Ala Ala Val Ser Pro Arg Leu Ser Phe Ala Gly Thr Gly 
            100                 105                 110         


Met His Arg Arg Trp Leu Ser Gly Arg Lys Ile Pro Phe His Phe Val 
        115                 120                 125             


Leu Ser Leu Pro Pro Gln Gly Ser Gln Pro Pro Leu Gly Ser Ala Gly 
    130                 135                 140                 


Pro Asp Pro Val Pro Ala Ala Leu His Gly His Ser Arg Ile Arg Cys 
145                 150                 155                 160 


Arg Ser Ser Arg His Pro Gln Glu Pro Pro Gly Pro Ser Arg Arg Arg 
                165                 170                 175     


Arg Arg Gly Pro Asp Pro His Thr Met Pro Ser Glu Lys Thr Phe Lys 
            180                 185                 190         


Gln Arg Arg Thr Phe Glu Gln Arg Val Glu Asp Val Arg Leu Ile Arg 
        195                 200                 205             


Glu Gln His Pro Thr Lys Ile Pro Val Ile Ile Glu Arg Tyr Lys Gly 
    210                 215                 220                 


Glu Lys Gln Leu Pro Val Leu Asp Lys Thr Lys Phe Leu Val Pro Asp 
225                 230                 235                 240 


His Val Asn Met Ser Glu Leu Ile Lys Ile Ile Arg Arg Arg Leu Gln 
                245                 250                 255     


Leu Asn Ala Asn Gln Ala Phe Phe Leu Leu Val Asn Gly His Ser Met 
            260                 265                 270         


Val Ser Val Ser Thr Pro Ile Ser Glu Val Tyr Glu Ser Glu Lys Asp 
        275                 280                 285             


Glu Asp Gly Phe Leu Tyr Met Val Cys Ala Ser Gln Glu Thr Phe Gly 
    290                 295                 300                 


Met Lys Leu Ser Val 
305                 


<210>  5107
<211>  1224
<212>  DNA
<213>  Homosapiens

<400>  5107
atgctacggt acattgctac gcttagacgc accaggaaag ctctggacga ggaagatgta     60

ggttgttgcc agcacctatg cacggacaga cagaaagtcc tctgcttcct tcaggccctt    120

gcttccactt ccccggggct tccagctgag cctgcatttt tctttgactt ccccctcttg    180

cctggcgttt tcagcaaaca cacacagagg attacgggga gaaaactatc atattaccaa    240

gtggacatgg ctcctaaggt gccaactgaa cacagcaaca gcgacgaggc ccgaggtgca    300

gctgtctcgc ctcgcctgtc ttttgcaggc accggcatgc acagaagatg gctctccggg    360

aggaagattc ctttccattt tgttctctct ctgcctccgc aaggctcgca gccacctctc    420

gggagtgcag ggccagatcc tgtgccagcg gccttacacg gccacagtcg gattcgctgc    480

cgcagcagcc gccaccccca ggagccgccg ggaccctcgc gtcgtcgccg ccgcggccca    540

gatccccaca ccatgccgtc ggagaagacc ttcaagcagc ggcgcacctt cgaacaaaga    600

gtagaagatg tccgacttat tcgagagcag catccaacca aaatcccggt gataatagaa    660

cgatacaagg gtgagaagca gcttcctgtt ctggataaaa caaagttcct tgtacctgac    720

catgtcaaca tgagtgagct catcaagata attagaaggc gcttacagct caatgctaat    780

caggccttct tcctgttggt gaacggacac agcatggtca gcgtctccac accaatctca    840

gaggtgtatg agagtgagaa agatgaagat ggattcctgt acatggtctg tgcctcccag    900

gagacgttcg ggatgaaatt gtcagtgtaa aaccagaaaa aatgcatctc ttctagaatt    960

ttttaaaccc ttaccaagga aaaaaaaagg gatgttacca actgagatcg atcagttcat   1020

ctaatcacag atcatcaaac agtagtgttc ccacctagga gtgttaggaa gttgtgtttg   1080

tgtttcaagc agaaaaactg agctccaagt gagcacattc agctttggaa actatattat   1140

ttaatgtagg ctagcttgtt ttcaaatttt aaaagtttaa aaataaaata ctttgcattc   1200

taaaaaaaaa aaaaaattgc ctta                                          1224


<210>  5108
<211>  309
<212>  PRT
<213>  Homosapiens

<400>  5108

Met Leu Arg Tyr Ile Ala Thr Leu Arg Arg Thr Arg Lys Ala Leu Asp 
1               5                   10                  15      


Glu Glu Asp Val Gly Cys Cys Gln His Leu Cys Thr Asp Arg Gln Lys 
            20                  25                  30          


Val Leu Cys Phe Leu Gln Ala Leu Ala Ser Thr Ser Pro Gly Leu Pro 
        35                  40                  45              


Ala Glu Pro Ala Phe Phe Phe Asp Phe Pro Leu Leu Pro Gly Val Phe 
    50                  55                  60                  


Ser Lys His Thr Gln Arg Ile Thr Gly Arg Lys Leu Ser Tyr Tyr Gln 
65                  70                  75                  80  


Val Asp Met Ala Pro Lys Val Pro Thr Glu His Ser Asn Ser Asp Glu 
                85                  90                  95      


Ala Arg Gly Ala Ala Val Ser Pro Arg Leu Ser Phe Ala Gly Thr Gly 
            100                 105                 110         


Met His Arg Arg Trp Leu Ser Gly Arg Lys Ile Pro Phe His Phe Val 
        115                 120                 125             


Leu Ser Leu Pro Pro Gln Gly Ser Gln Pro Pro Leu Gly Ser Ala Gly 
    130                 135                 140                 


Pro Asp Pro Val Pro Ala Ala Leu His Gly His Ser Arg Ile Arg Cys 
145                 150                 155                 160 


Arg Ser Ser Arg His Pro Gln Glu Pro Pro Gly Pro Ser Arg Arg Arg 
                165                 170                 175     


Arg Arg Gly Pro Asp Pro His Thr Met Pro Ser Glu Lys Thr Phe Lys 
            180                 185                 190         


Gln Arg Arg Thr Phe Glu Gln Arg Val Glu Asp Val Arg Leu Ile Arg 
        195                 200                 205             


Glu Gln His Pro Thr Lys Ile Pro Val Ile Ile Glu Arg Tyr Lys Gly 
    210                 215                 220                 


Glu Lys Gln Leu Pro Val Leu Asp Lys Thr Lys Phe Leu Val Pro Asp 
225                 230                 235                 240 


His Val Asn Met Ser Glu Leu Ile Lys Ile Ile Arg Arg Arg Leu Gln 
                245                 250                 255     


Leu Asn Ala Asn Gln Ala Phe Phe Leu Leu Val Asn Gly His Ser Met 
            260                 265                 270         


Val Ser Val Ser Thr Pro Ile Ser Glu Val Tyr Glu Ser Glu Lys Asp 
        275                 280                 285             


Glu Asp Gly Phe Leu Tyr Met Val Cys Ala Ser Gln Glu Thr Phe Gly 
    290                 295                 300                 


Met Lys Leu Ser Val 
305                 


<210>  5109
<211>  324
<212>  DNA
<213>  Homosapiens

<400>  5109
atgtgcgccg cctcccccaa ccccaagcaa gatgctagag ccgcctgttt gaccatcttc     60

accaacgagg tggaaagatg gagcaagctg gtgaagtact tcagccggca gctgtcctgc    120

aaaaagaagg tagccttgca ggagcgcaac gcggagctgg acggcttccc ccagctacgg    180

cactggttcc gaatcgtcga tgtgcgcaag gaggtcctgg agagtcacct tggccaaatc    240

acttcacttc ttagtccagc gctgtccagt ggaactttct gctacgatgg aaatattttc    300

tatctgtgct gccggctgtg gtag                                           324


<210>  5110
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  5110

Met Cys Ala Ala Ser Pro Asn Pro Lys Gln Asp Ala Arg Ala Ala Cys 
1               5                   10                  15      


Leu Thr Ile Phe Thr Asn Glu Val Glu Arg Trp Ser Lys Leu Val Lys 
            20                  25                  30          


Tyr Phe Ser Arg Gln Leu Ser Cys Lys Lys Lys Val Ala Leu Gln Glu 
        35                  40                  45              


Arg Asn Ala Glu Leu Asp Gly Phe Pro Gln Leu Arg His Trp Phe Arg 
    50                  55                  60                  


Ile Val Asp Val Arg Lys Glu Val Leu Glu Ser His Leu Gly Gln Ile 
65                  70                  75                  80  


Thr Ser Leu Leu Ser Pro Ala Leu Ser Ser Gly Thr Phe Cys Tyr Asp 
                85                  90                  95      


Gly Asn Ile Phe Tyr Leu Cys Cys Arg Leu Trp 
            100                 105         


<210>  5111
<211>  231
<212>  DNA
<213>  Homosapiens

<400>  5111
atggatgagg aaaacatgac gaaaagcgag gagcagcagc ctctgagttt gcaaaaagcc     60

ttacagcagt gcgaactggt ccaaaacatg atagacttga gcatctccaa cctggaaggg    120

cttaggacca aatgtgctac ctccaacgac ctcacacaaa aagaaatccg gaccctggag    180

gtggtcaaaa ggtggttttt gctcacagaa tggggccgcc tgtcagtgta g             231


<210>  5112
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  5112

Met Asp Glu Glu Asn Met Thr Lys Ser Glu Glu Gln Gln Pro Leu Ser 
1               5                   10                  15      


Leu Gln Lys Ala Leu Gln Gln Cys Glu Leu Val Gln Asn Met Ile Asp 
            20                  25                  30          


Leu Ser Ile Ser Asn Leu Glu Gly Leu Arg Thr Lys Cys Ala Thr Ser 
        35                  40                  45              


Asn Asp Leu Thr Gln Lys Glu Ile Arg Thr Leu Glu Val Val Lys Arg 
    50                  55                  60                  


Trp Phe Leu Leu Thr Glu Trp Gly Arg Leu Ser Val 
65                  70                  75      


<210>  5113
<211>  372
<212>  DNA
<213>  Homosapiens

<400>  5113
atgggcggcg gcggctccga gccgcgcggg cccgcacact cagccggtgc ggcccgggcc     60

tcgagctctt cctgtggcct ggccgcggcc ccgcactatg gggctccaga ctgcagcggc    120

cgcccccggt tctgccaccg cggccgccgc tccagctgcc gccacagcag tccgcgaggt    180

cccgccccca agccactgcc ggttgtcgcc gcacgacgtg gcggcagggc caaccagcgc    240

gaacccggcg ggtacgacca ctgcagctgg cgctccgccg gactggacgc agagctaaat    300

cccgcgcggc tccccggctt tcctggagga gtctcgccga gtgtgcacgc cgcgaagctc    360

acccgttcct ag                                                        372


<210>  5114
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  5114

Met Gly Gly Gly Gly Ser Glu Pro Arg Gly Pro Ala His Ser Ala Gly 
1               5                   10                  15      


Ala Ala Arg Ala Ser Ser Ser Ser Cys Gly Leu Ala Ala Ala Pro His 
            20                  25                  30          


Tyr Gly Ala Pro Asp Cys Ser Gly Arg Pro Arg Phe Cys His Arg Gly 
        35                  40                  45              


Arg Arg Ser Ser Cys Arg His Ser Ser Pro Arg Gly Pro Ala Pro Lys 
    50                  55                  60                  


Pro Leu Pro Val Val Ala Ala Arg Arg Gly Gly Arg Ala Asn Gln Arg 
65                  70                  75                  80  


Glu Pro Gly Gly Tyr Asp His Cys Ser Trp Arg Ser Ala Gly Leu Asp 
                85                  90                  95      


Ala Glu Leu Asn Pro Ala Arg Leu Pro Gly Phe Pro Gly Gly Val Ser 
            100                 105                 110         


Pro Ser Val His Ala Ala Lys Leu Thr Arg Ser 
        115                 120             


<210>  5115
<211>  372
<212>  DNA
<213>  Homosapiens

<400>  5115
atgggcggcg gcggctccga gccgcgcggg cccgcacact cagccggtgc ggcccgggcc     60

tcgagctctt cctgtggcct ggccgcggcc ccgcactatg gggctccaga ctgcagcggc    120

cgcccccggt tctgccaccg cggccgccgc tccagctgcc gccacagcag tccgcgaggt    180

cccgccccca agccactgcc ggttgtcgcc gcacgacgtg gcggcagggc caaccagcgc    240

gaacccggcg ggtacgacca ctgcagctgg cgctccgccg gactggacgc agagctaaat    300

cccgcgcggc tccccggctt tcctggagga gtctcgccga gtgtgcacgc cgcgaagctc    360

acccgttcct ag                                                        372


<210>  5116
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  5116

Met Gly Gly Gly Gly Ser Glu Pro Arg Gly Pro Ala His Ser Ala Gly 
1               5                   10                  15      


Ala Ala Arg Ala Ser Ser Ser Ser Cys Gly Leu Ala Ala Ala Pro His 
            20                  25                  30          


Tyr Gly Ala Pro Asp Cys Ser Gly Arg Pro Arg Phe Cys His Arg Gly 
        35                  40                  45              


Arg Arg Ser Ser Cys Arg His Ser Ser Pro Arg Gly Pro Ala Pro Lys 
    50                  55                  60                  


Pro Leu Pro Val Val Ala Ala Arg Arg Gly Gly Arg Ala Asn Gln Arg 
65                  70                  75                  80  


Glu Pro Gly Gly Tyr Asp His Cys Ser Trp Arg Ser Ala Gly Leu Asp 
                85                  90                  95      


Ala Glu Leu Asn Pro Ala Arg Leu Pro Gly Phe Pro Gly Gly Val Ser 
            100                 105                 110         


Pro Ser Val His Ala Ala Lys Leu Thr Arg Ser 
        115                 120             


<210>  5117
<211>  3423
<212>  DNA
<213>  Homosapiens

<400>  5117
aaatcagcac aggacgagta caaccgtggg agtcacacct ggagaagtct ctaattcctc     60

tgggcatgaa tcagacctgc cgcccatgcc tggggaggca gtagaatatc acagtattca    120

attaatacgg gatgaatttt taatgaacgt gcagaaattt gcaagtaata ttcaaagaac    180

catgcagcaa cttgaaggtg agatcaagtt agaaatgcca atcatcagtg tggagggaga    240

ggtgtccgac ctggcagctg acccggaaac cgttgacatc ttggagcagt gtgtgataaa    300

ctggctgaat cagatatcca cagcggttga ggcccaactg aagaagacac ctcagggtaa    360

aggccctctg gctgaaattg aattctggag ggaaagaaat gcaaccttaa gtgcgctgca    420

tgaacaaaca aagcttccaa tagtcagaaa agtcttggat gtgatcaagg aatccgactc    480

catgcttgtg gctaatctgc agccagtgtt caccgagtta ttcaagttcc acacggaggc    540

ctcagacaat gtgcgctttc tctccaccgt ggagcgttat ttcaagaaca taacgcacgg    600

gtctggcttc cacgtggtcc tggacaccat ccccgccatg atgagtgccc tgcggatggt    660

gtggatcatc tcccgacact acaacaaaga cgagaggatg attccgctca tggagcgcat    720

cgcctgggaa atcgctgaga gagtctgccg agtggtcaac ctgcggactt tgttcaaaga    780

aaatcgagcg agtgcccaaa gcaaaacctt ggaagccagg aacaccctca ggctgtggaa    840

aaaggcctat tttgacaccc gggccaagat agaggcttcg gggagggaag atcggtggga    900

gtttgaccgg aagcggctgt tcgagaggac ggattatatg gccaccatct gccaggacct    960

ctccgacgtt ctgcaggttt tggaggaatt ttataacata tttggtccag aactaaaggc   1020

agtgacgggg gaccccaagc gcattgatga tgtcctatgc agagtggacg gcctagtcac   1080

ccccatggaa aacctgacct ttgacccctt cagcatcaag tcctcccagt tctggaaata   1140

tgtgatggat gaattcaaga ttgaagttct gattgacatc attaataaaa tctttgtcca   1200

gaaccttgaa aatccaccac tgtataagaa tcaccctcca gtagcaggtg caatatactg   1260

ggaacgatct ctgttctttc ggattaagca taccatcctc cgatttcaag aggtacaaga   1320

gatactggac agtgatcgag gacaggaggt caaacaaaaa tatttggaag taggtaggac   1380

aatgaaggag tatgaagaca gaaagtatga gcagtggatg gaggtgacgg agcaggtgct   1440

gccagctctc atgaagaaga gccttttgac caagtcttcc atcgccacag aggagccttc   1500

gactttagaa aggggagctg tttttgcaat caacttttca ccggctctca gagagattat   1560

taatgaaaca aagtacttag agcagctggg gttcactgtc cctgaattag caagaaatgt   1620

tgctctccag gaagacaaat tccttaggta cacagctggg atacagcgca tgttggatca   1680

ttatcacatg ctcataggaa cgttaaacga tgcggagtct gtgcttctca aagatcattc   1740

ccaggaactg ctccgagtgt ttaggtcggg atataagagg ttgaactgga actcactagg   1800

tatcggtgac tatataactg gttgcaaaca ggccattggg aaatttgagt ctctcgtcca   1860

ccagattcat aagaatgcag atgacatttc ttccaggctg acattaatag aggccataaa   1920

tctctttaaa tatccagccg ctaaaagtga ggaagaactc ccaggcgtga aggaattttt   1980

tgaacacatt gagcgagaaa gggccagcga cgtggaccac atggtccggt ggtatcttgc   2040

cattggacca ctgctgacca aagttgaggg cctggtcgtc cacaccaaca caggcaaggc   2100

ccccaagctg gcctcctact acaaatactg ggaaaagaaa atttatgagg tcctgacaaa   2160

gctcatcctg aagaacttgc agtcttttaa ttctttgatc cttggaaatg tccctctgtt   2220

ccacactgaa accattctga cggcacctga gatcatcctt catcccaaca caaatgagat   2280

cgacaagatg tgcttccatt gtgtccggaa ttgcgtggag atcaccaagc attttgttcg   2340

ttggatgaat ggcagctgca tagaatgccc acctcagaag ggggaggaag aggaagttgt   2400

tataataaac ttttacaatg atatctctct gaaccctcag ataattgaac aagctgttat   2460

gatcccccaa aatgtccaca ggattctgat caatcttatg aagtatctac aaaaatggaa   2520

gcggtatcga cctctctgga aattggacaa agctattgtg atggagaaat ttgctgccaa   2580

gaaacctcct tgtgtagcat atgatgaaaa gttgcagttc tattccaaga tagcttatga   2640

ggttatgcgc caccctctaa ttaaggatga gcattgcatc agacttcagc tcaggcatct   2700

ggcaaacaca gtgcaggaaa atgccaagtc ctgggtgatt tcgcttggaa aacttctcaa   2760

tgagtcagca aaagaggagc tctataatct ccatgaagag atggaggtac tcaatcgctg   2820

tgtgtaattg aaactacttt tcgtgtaagt tgggtcttca tttgcgccat tactgttttt   2880

tctgtgtttg cttagtgttc tttgtacttt ctgttatagc acctggccaa aaaccttagg   2940

aagatcccca atacccttga agatctcaag tttgtccttg caacaattgc agaaattaga   3000

agtaaatctc tagtcatgga actcagatat agggacgtcc aggagcgata ccgtaccatg   3060

gcaatgtata acctctttgt aagtcaactt gtattttctt attcatttaa caattggatt   3120

gaccactaac gacccttttc agaaatgctt ctcaagtata ctgccattga tttgttttca   3180

aataagtgac tttaagtaat acattgtaaa tgtaaagcaa tgccactgtt atttagaata   3240

atgaaaatat agagtatttt tcaatctgta tggctcaaat ggattgatct gtaactatac   3300

catttccatt ctcccttttc ttttcttctt ttttttgtgt taatttcctt taatagataa   3360

agagctcttg caaaaatgat aagaagagag tgaaagattt aagataataa aagaaactgg   3420

tag                                                                 3423


<210>  5118
<211>  913
<212>  PRT
<213>  Homosapiens

<400>  5118

Met Pro Gly Glu Ala Val Glu Tyr His Ser Ile Gln Leu Ile Arg Asp 
1               5                   10                  15      


Glu Phe Leu Met Asn Val Gln Lys Phe Ala Ser Asn Ile Gln Arg Thr 
            20                  25                  30          


Met Gln Gln Leu Glu Gly Glu Ile Lys Leu Glu Met Pro Ile Ile Ser 
        35                  40                  45              


Val Glu Gly Glu Val Ser Asp Leu Ala Ala Asp Pro Glu Thr Val Asp 
    50                  55                  60                  


Ile Leu Glu Gln Cys Val Ile Asn Trp Leu Asn Gln Ile Ser Thr Ala 
65                  70                  75                  80  


Val Glu Ala Gln Leu Lys Lys Thr Pro Gln Gly Lys Gly Pro Leu Ala 
                85                  90                  95      


Glu Ile Glu Phe Trp Arg Glu Arg Asn Ala Thr Leu Ser Ala Leu His 
            100                 105                 110         


Glu Gln Thr Lys Leu Pro Ile Val Arg Lys Val Leu Asp Val Ile Lys 
        115                 120                 125             


Glu Ser Asp Ser Met Leu Val Ala Asn Leu Gln Pro Val Phe Thr Glu 
    130                 135                 140                 


Leu Phe Lys Phe His Thr Glu Ala Ser Asp Asn Val Arg Phe Leu Ser 
145                 150                 155                 160 


Thr Val Glu Arg Tyr Phe Lys Asn Ile Thr His Gly Ser Gly Phe His 
                165                 170                 175     


Val Val Leu Asp Thr Ile Pro Ala Met Met Ser Ala Leu Arg Met Val 
            180                 185                 190         


Trp Ile Ile Ser Arg His Tyr Asn Lys Asp Glu Arg Met Ile Pro Leu 
        195                 200                 205             


Met Glu Arg Ile Ala Trp Glu Ile Ala Glu Arg Val Cys Arg Val Val 
    210                 215                 220                 


Asn Leu Arg Thr Leu Phe Lys Glu Asn Arg Ala Ser Ala Gln Ser Lys 
225                 230                 235                 240 


Thr Leu Glu Ala Arg Asn Thr Leu Arg Leu Trp Lys Lys Ala Tyr Phe 
                245                 250                 255     


Asp Thr Arg Ala Lys Ile Glu Ala Ser Gly Arg Glu Asp Arg Trp Glu 
            260                 265                 270         


Phe Asp Arg Lys Arg Leu Phe Glu Arg Thr Asp Tyr Met Ala Thr Ile 
        275                 280                 285             


Cys Gln Asp Leu Ser Asp Val Leu Gln Val Leu Glu Glu Phe Tyr Asn 
    290                 295                 300                 


Ile Phe Gly Pro Glu Leu Lys Ala Val Thr Gly Asp Pro Lys Arg Ile 
305                 310                 315                 320 


Asp Asp Val Leu Cys Arg Val Asp Gly Leu Val Thr Pro Met Glu Asn 
                325                 330                 335     


Leu Thr Phe Asp Pro Phe Ser Ile Lys Ser Ser Gln Phe Trp Lys Tyr 
            340                 345                 350         


Val Met Asp Glu Phe Lys Ile Glu Val Leu Ile Asp Ile Ile Asn Lys 
        355                 360                 365             


Ile Phe Val Gln Asn Leu Glu Asn Pro Pro Leu Tyr Lys Asn His Pro 
    370                 375                 380                 


Pro Val Ala Gly Ala Ile Tyr Trp Glu Arg Ser Leu Phe Phe Arg Ile 
385                 390                 395                 400 


Lys His Thr Ile Leu Arg Phe Gln Glu Val Gln Glu Ile Leu Asp Ser 
                405                 410                 415     


Asp Arg Gly Gln Glu Val Lys Gln Lys Tyr Leu Glu Val Gly Arg Thr 
            420                 425                 430         


Met Lys Glu Tyr Glu Asp Arg Lys Tyr Glu Gln Trp Met Glu Val Thr 
        435                 440                 445             


Glu Gln Val Leu Pro Ala Leu Met Lys Lys Ser Leu Leu Thr Lys Ser 
    450                 455                 460                 


Ser Ile Ala Thr Glu Glu Pro Ser Thr Leu Glu Arg Gly Ala Val Phe 
465                 470                 475                 480 


Ala Ile Asn Phe Ser Pro Ala Leu Arg Glu Ile Ile Asn Glu Thr Lys 
                485                 490                 495     


Tyr Leu Glu Gln Leu Gly Phe Thr Val Pro Glu Leu Ala Arg Asn Val 
            500                 505                 510         


Ala Leu Gln Glu Asp Lys Phe Leu Arg Tyr Thr Ala Gly Ile Gln Arg 
        515                 520                 525             


Met Leu Asp His Tyr His Met Leu Ile Gly Thr Leu Asn Asp Ala Glu 
    530                 535                 540                 


Ser Val Leu Leu Lys Asp His Ser Gln Glu Leu Leu Arg Val Phe Arg 
545                 550                 555                 560 


Ser Gly Tyr Lys Arg Leu Asn Trp Asn Ser Leu Gly Ile Gly Asp Tyr 
                565                 570                 575     


Ile Thr Gly Cys Lys Gln Ala Ile Gly Lys Phe Glu Ser Leu Val His 
            580                 585                 590         


Gln Ile His Lys Asn Ala Asp Asp Ile Ser Ser Arg Leu Thr Leu Ile 
        595                 600                 605             


Glu Ala Ile Asn Leu Phe Lys Tyr Pro Ala Ala Lys Ser Glu Glu Glu 
    610                 615                 620                 


Leu Pro Gly Val Lys Glu Phe Phe Glu His Ile Glu Arg Glu Arg Ala 
625                 630                 635                 640 


Ser Asp Val Asp His Met Val Arg Trp Tyr Leu Ala Ile Gly Pro Leu 
                645                 650                 655     


Leu Thr Lys Val Glu Gly Leu Val Val His Thr Asn Thr Gly Lys Ala 
            660                 665                 670         


Pro Lys Leu Ala Ser Tyr Tyr Lys Tyr Trp Glu Lys Lys Ile Tyr Glu 
        675                 680                 685             


Val Leu Thr Lys Leu Ile Leu Lys Asn Leu Gln Ser Phe Asn Ser Leu 
    690                 695                 700                 


Ile Leu Gly Asn Val Pro Leu Phe His Thr Glu Thr Ile Leu Thr Ala 
705                 710                 715                 720 


Pro Glu Ile Ile Leu His Pro Asn Thr Asn Glu Ile Asp Lys Met Cys 
                725                 730                 735     


Phe His Cys Val Arg Asn Cys Val Glu Ile Thr Lys His Phe Val Arg 
            740                 745                 750         


Trp Met Asn Gly Ser Cys Ile Glu Cys Pro Pro Gln Lys Gly Glu Glu 
        755                 760                 765             


Glu Glu Val Val Ile Ile Asn Phe Tyr Asn Asp Ile Ser Leu Asn Pro 
    770                 775                 780                 


Gln Ile Ile Glu Gln Ala Val Met Ile Pro Gln Asn Val His Arg Ile 
785                 790                 795                 800 


Leu Ile Asn Leu Met Lys Tyr Leu Gln Lys Trp Lys Arg Tyr Arg Pro 
                805                 810                 815     


Leu Trp Lys Leu Asp Lys Ala Ile Val Met Glu Lys Phe Ala Ala Lys 
            820                 825                 830         


Lys Pro Pro Cys Val Ala Tyr Asp Glu Lys Leu Gln Phe Tyr Ser Lys 
        835                 840                 845             


Ile Ala Tyr Glu Val Met Arg His Pro Leu Ile Lys Asp Glu His Cys 
    850                 855                 860                 


Ile Arg Leu Gln Leu Arg His Leu Ala Asn Thr Val Gln Glu Asn Ala 
865                 870                 875                 880 


Lys Ser Trp Val Ile Ser Leu Gly Lys Leu Leu Asn Glu Ser Ala Lys 
                885                 890                 895     


Glu Glu Leu Tyr Asn Leu His Glu Glu Met Glu Val Leu Asn Arg Cys 
            900                 905                 910         


Val 
    


<210>  5119
<211>  123
<212>  DNA
<213>  Homosapiens

<400>  5119
atgggtgcct cgctggatca gaaacgcagc ggacaccctg ccggatccgg aggggtggaa     60

gttagtggcg ggtctgcgac ggcggcaatc agcagtggtg gatggcttgt tctctgtcgc    120

tga                                                                  123


<210>  5120
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5120

Met Gly Ala Ser Leu Asp Gln Lys Arg Ser Gly His Pro Ala Gly Ser 
1               5                   10                  15      


Gly Gly Val Glu Val Ser Gly Gly Ser Ala Thr Ala Ala Ile Ser Ser 
            20                  25                  30          


Gly Gly Trp Leu Val Leu Cys Arg 
        35                  40  


<210>  5121
<211>  1698
<212>  DNA
<213>  Homosapiens

<400>  5121
catgaagcaa taaacatagg aggacctcac tctgttgtgc atgctggagt acagtggcgc     60

agtctctgct ccctgaaacc tcgacttcca gggctcaaga gatccttcca tcttaccaag    120

tagctgggac tacagatgta tagttatttt ccaaacccac cattgtaaaa ttacattcta    180

ttaaagagaa aaagaagaaa aagaaactta atttgttttt tgggggatag ttgagatgtg    240

tttaacacag cccctgctgg taaccaaggt cctcctccaa tgacgggtat gaatatgaac    300

aacagagcaa ctatacctgg cccaccagtg ggtcctggtc ctgccatggg accagaagga    360

gccgcaaata tgggaactcc aatgatgcca gataatggag cagtggaaga accggaacta    420

tgatttgtgc cttccttatt gcctccgaaa tatttttaac tgcagaggaa agcctgtatt    480

attttggaga aaggcgaaca gataaaacgc acagcagtaa atttcaggga ctagaaactc    540

cttctcagta gagacaaggt ttcaccctgt tggcgaggct ggtctcaaac tcctgacgcc    600

cagtgatctg cccacctcgg cctcccaaag tgctgggatt acaggcggga gccaccatga    660

tggccaactt ttgaattctg aaccagttga ttgagtacca gagctcttca ataccttgaa    720

gaaagattca ggggagagcc gttgtgaaca gcttgcccca gggaaaggac aaggctgaga    780

gaattccagg gcttccttga gaaaacagaa ttgaggaaat gcaaagtgaa gaattctagc    840

atcaggaaca agagaagaat gatggaaaac ctgctactga gatatgttgg atattttgca    900

caagtgaaac atctctacaa ctggaatctc cctccaagac ggatactctt tataataaga    960

ttcattattt attcgattcg tggtgttgga acaggcgatg tatgtgatct aaaattccaa   1020

atagtaatgg agaaaaaggt tgtcttttcc agtacttcat taggaaattg ttcaatactg   1080

catgacattg aaacagctgg tgtattaact aatgtatatg acagtccatc tctgtacgat   1140

gatgtgaaag tgcagttttt ctcttcgaat cttcctaaat actatgacaa ttgttcattt   1200

ttcttctggt tcaacacatc ttttattcaa aataacagag agaaatttag atattttatt   1260

aaacttggaa gtcattaatg ccatataaag caatgctaag agagtcagca tgtgttactg   1320

atgtgttgct gaagattaaa gtatttttaa gtctcaccaa aaaggtggaa ggagccaact   1380

gagacacaaa aaaggggctg aggttctatt cacggcttta tctaccaaga aatgaattgg   1440

ataatccaca tcaacaaaaa gcatggaaaa tttatccacc agaatttgcc gtggagatac   1500

tttttggcga gaaatgactt ccaatgacgt agctggatcc gattaagtat agtttcccct   1560

tccccttctg ggaaagaatt aatgttcttt ccaacccctg ccatgtgcat gttcatatgt   1620

cctaagtctt ccttgatgat gtatctatat ttatatatgt ttatatatgt tcttcataaa   1680

tctattaaat atatatag                                                 1698


<210>  5122
<211>  699
<212>  DNA
<213>  Homosapiens

<400>  5122
ttctgtgaaa tagttttgtc tttagcagtc gtttgtttca gttataacgg ttataaatgg     60

cacttcattt gatttcttta aacattttac ttggcctgct gtttaatcag acatggaagc    120

caggacctcg ggacgggggc ggggctccga cagaggcggc gattgtggcg gcccatttgt    180

aaatgctgcg gagattgagg tgtcggttcg tgctgctgag ctgcccaggc ttcacggagc    240

gagctgggga agccggcctc tctggggtgt ctgtctctct gacctggctg tggcggaact    300

tgagttcctg tgggcagcgc ggcagccgca gtccgctgga gcagggtggt gaagtagcgt    360

tgctggctgt cctaagggcc ggtcttgccc cagctttgtc aagggcttct ctcttgaagc    420

ttcgtgtgga ttcatggctt tcaagaacgt gttgtatttt aggggactgc taaatcactt    480

cccagaccaa ctagttactt ctcacggtct aagagtggct ttgaatttgc tgtttgtatc    540

cactctcctc cctcaccgtg cagagaattt atcttttttt caatactgct ttaaagaatg    600

tttacatagc actttctgga gatttcaagg ctgtcagttt gttacatttt ttaaaagttt    660

tattgaggta taattgctat acaataaaaa tggcacatg                           699


<210>  5123
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  5123

Met Glu Ala Arg Thr Ser Gly Arg Gly Arg Gly Ser Asp Arg Gly Gly 
1               5                   10                  15      


Asp Cys Gly Gly Pro Phe Val Asn Ala Ala Glu Ile Glu Val Ser Val 
            20                  25                  30          


Arg Ala Ala Glu Leu Pro Arg Leu His Gly Ala Ser Trp Gly Ser Arg 
        35                  40                  45              


Pro Leu Trp Gly Val Cys Leu Ser Asp Leu Ala Val Ala Glu Leu Glu 
    50                  55                  60                  


Phe Leu Trp Ala Ala Arg Gln Pro Gln Ser Ala Gly Ala Gly Trp 
65                  70                  75                  


<210>  5124
<211>  561
<212>  DNA
<213>  Homosapiens

<400>  5124
atgccggcag cgtttccctg tgtctttccc ccacaaagtc tccaagtctt tcctcaaatg     60

atcgtcaagg tttgggagaa acaatctctt cctctgcccg ggttgcgtgg atctccagtg    120

gaaaggaaga accggaacta tggtttgtgc ctgccttatt gcctccaaaa tatttttaac    180

tgcagaggct ttatctacca agaaatgaat tggataatcc acataaacaa aaagcttgga    240

aaatttatcc accagaattt gccgtggaga tactttttgg aacctggctt accagtatat    300

caccccagcg ttgacacact gggaacgggt cacgcatgtg gatgatcaaa ggtcagctcc    360

tggtcaatat gagaagactg gtttcagaaa agttgagtgc tgaagactac aaagctgttt    420

gtaagttatc aagctaggat ttgatcccag gtctgcctga taaatcctgg actcttaacc    480

atgacatagg agtgccctct tgactcctat gatggcataa agaattgtat cagaacgggt    540

aatctggcat taaaacccct g                                              561


<210>  5125
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  5125

Met Pro Ala Ala Phe Pro Cys Val Phe Pro Pro Gln Ser Leu Gln Val 
1               5                   10                  15      


Phe Pro Gln Met Ile Val Lys Val Trp Glu Lys Gln Ser Leu Pro Leu 
            20                  25                  30          


Pro Gly Leu Arg Gly Ser Pro Val Glu Arg Lys Asn Arg Asn Tyr Gly 
        35                  40                  45              


Leu Cys Leu Pro Tyr Cys Leu Gln Asn Ile Phe Asn Cys Arg Gly Phe 
    50                  55                  60                  


Ile Tyr Gln Glu Met Asn Trp Ile Ile His Ile Asn Lys Lys Leu Gly 
65                  70                  75                  80  


Lys Phe Ile His Gln Asn Leu Pro Trp Arg Tyr Phe Leu Glu Pro Gly 
                85                  90                  95      


Leu Pro Val Tyr His Pro Ser Val Asp Thr Leu Gly Thr Gly His Ala 
            100                 105                 110         


Cys Gly 
        


<210>  5126
<211>  396
<212>  DNA
<213>  Homosapiens

<400>  5126
atggcggaag cagtcaccta cctcataagt tgtgatgagg actggttgct gagaggactc     60

acaacaccta acccacagtg gaaacaacaa aattccccat taaacaccta cttctctctt    120

ccaacatgtt ccttgcctgt caaccgcaca ccttctcctt atctccccac aagacagaat    180

ctaaatatct tgcttgatgc tctgagcagt ccagtccaca ccttcagctt caaaccccat    240

actgaaaaac acagggctgg ggtcagcaaa tgcctgcctg gcctgacagc tggtgtggtt    300

ctgaagctcc acaactttgg cctaatcatc tctctcaggg gttctcctct cccctgtcct    360

tggggaagga aacaagacaa gtcaacccca gtgtga                              396


<210>  5127
<211>  131
<212>  PRT
<213>  Homosapiens

<400>  5127

Met Ala Glu Ala Val Thr Tyr Leu Ile Ser Cys Asp Glu Asp Trp Leu 
1               5                   10                  15      


Leu Arg Gly Leu Thr Thr Pro Asn Pro Gln Trp Lys Gln Gln Asn Ser 
            20                  25                  30          


Pro Leu Asn Thr Tyr Phe Ser Leu Pro Thr Cys Ser Leu Pro Val Asn 
        35                  40                  45              


Arg Thr Pro Ser Pro Tyr Leu Pro Thr Arg Gln Asn Leu Asn Ile Leu 
    50                  55                  60                  


Leu Asp Ala Leu Ser Ser Pro Val His Thr Phe Ser Phe Lys Pro His 
65                  70                  75                  80  


Thr Glu Lys His Arg Ala Gly Val Ser Lys Cys Leu Pro Gly Leu Thr 
                85                  90                  95      


Ala Gly Val Val Leu Lys Leu His Asn Phe Gly Leu Ile Ile Ser Leu 
            100                 105                 110         


Arg Gly Ser Pro Leu Pro Cys Pro Trp Gly Arg Lys Gln Asp Lys Ser 
        115                 120                 125             


Thr Pro Val 
    130     


<210>  5128
<211>  396
<212>  DNA
<213>  Homosapiens

<400>  5128
atggcggaag cagtcaccta cctcataagt tgtgatgagg actggttgct gagaggactc     60

acaacaccta acccacagtg gaaacaacaa aattccccat taaacaccta cttctctctt    120

ccaacatgtt ccttgcctgt caaccgcaca ccttctcctt atctccccac aagacagaat    180

ctaaatatct tgcttgatgc tctgagcagt ccagtccaca ccttcagctt caaaccccat    240

actgaaaaac acagggctgg ggtcagcaaa tgcctgcctg gcctgacagc tggtgtggtt    300

ctgaagctcc acaactttgg cctaatcatc tctctcaggg gttctcctct cccctgtcct    360

tggggaagga aacaagacaa gtcaacccca gtgtga                              396


<210>  5129
<211>  131
<212>  PRT
<213>  Homosapiens

<400>  5129

Met Ala Glu Ala Val Thr Tyr Leu Ile Ser Cys Asp Glu Asp Trp Leu 
1               5                   10                  15      


Leu Arg Gly Leu Thr Thr Pro Asn Pro Gln Trp Lys Gln Gln Asn Ser 
            20                  25                  30          


Pro Leu Asn Thr Tyr Phe Ser Leu Pro Thr Cys Ser Leu Pro Val Asn 
        35                  40                  45              


Arg Thr Pro Ser Pro Tyr Leu Pro Thr Arg Gln Asn Leu Asn Ile Leu 
    50                  55                  60                  


Leu Asp Ala Leu Ser Ser Pro Val His Thr Phe Ser Phe Lys Pro His 
65                  70                  75                  80  


Thr Glu Lys His Arg Ala Gly Val Ser Lys Cys Leu Pro Gly Leu Thr 
                85                  90                  95      


Ala Gly Val Val Leu Lys Leu His Asn Phe Gly Leu Ile Ile Ser Leu 
            100                 105                 110         


Arg Gly Ser Pro Leu Pro Cys Pro Trp Gly Arg Lys Gln Asp Lys Ser 
        115                 120                 125             


Thr Pro Val 
    130     


<210>  5130
<211>  798
<212>  DNA
<213>  Homosapiens

<400>  5130
atgggtgctt tagaagaagg cttcattgtg cccttctcct ctgactctga tgcacatttt     60

gatgctgcgg ttggatattt agaggacatt atcatggatg aagatttcca gttattacag    120

agaaatttca tcaacaacta ctaccaggag tttgaggaca ccaaagagaa taaactcacc    180

tacacaccta tttttaatga atatatttct ttggcaggaa agtatataga agaacagtat    240

atagaagaaa aacagttgct ggagcaaatt cttggcttta ccatggcaac tttcacaacg    300

ttacagcacc acaaagatga agtggttggt gacatactcc aaatgctgct caaatttaca    360

gattttctgg cttttaaaga aatgtttctg gactgcagag cagaaaaaga aggccagaga    420

ctggacttaa gccgtggttt agtggagact tcattgtgca aatcatcttc tatgacagct    480

tctcagaaca atctgcagca caaccagtta ccatcagttg gcgctagcac accaccgact    540

gcaggcttta ctgatgagga aactgaggct cggagaggct gtcacgaact tgctgtagtc    600

acacaggaac tggccgaagg ggccgcggcc gcacatgcgc agtcagtccc gttggttgtg    660

cgctcagccc cgcccccaga ggcgccgcgc tccctgacag cccgcgggcg tacacacgct    720

gacgcgcagg ctgcggtcgc gcaggcgcag tcggggcgcc ttcccggtat aggcgccttt    780

taccccagcg tgtcctga                                                  798


<210>  5131
<211>  265
<212>  PRT
<213>  Homosapiens

<400>  5131

Met Gly Ala Leu Glu Glu Gly Phe Ile Val Pro Phe Ser Ser Asp Ser 
1               5                   10                  15      


Asp Ala His Phe Asp Ala Ala Val Gly Tyr Leu Glu Asp Ile Ile Met 
            20                  25                  30          


Asp Glu Asp Phe Gln Leu Leu Gln Arg Asn Phe Ile Asn Asn Tyr Tyr 
        35                  40                  45              


Gln Glu Phe Glu Asp Thr Lys Glu Asn Lys Leu Thr Tyr Thr Pro Ile 
    50                  55                  60                  


Phe Asn Glu Tyr Ile Ser Leu Ala Gly Lys Tyr Ile Glu Glu Gln Tyr 
65                  70                  75                  80  


Ile Glu Glu Lys Gln Leu Leu Glu Gln Ile Leu Gly Phe Thr Met Ala 
                85                  90                  95      


Thr Phe Thr Thr Leu Gln His His Lys Asp Glu Val Val Gly Asp Ile 
            100                 105                 110         


Leu Gln Met Leu Leu Lys Phe Thr Asp Phe Leu Ala Phe Lys Glu Met 
        115                 120                 125             


Phe Leu Asp Cys Arg Ala Glu Lys Glu Gly Gln Arg Leu Asp Leu Ser 
    130                 135                 140                 


Arg Gly Leu Val Glu Thr Ser Leu Cys Lys Ser Ser Ser Met Thr Ala 
145                 150                 155                 160 


Ser Gln Asn Asn Leu Gln His Asn Gln Leu Pro Ser Val Gly Ala Ser 
                165                 170                 175     


Thr Pro Pro Thr Ala Gly Phe Thr Asp Glu Glu Thr Glu Ala Arg Arg 
            180                 185                 190         


Gly Cys His Glu Leu Ala Val Val Thr Gln Glu Leu Ala Glu Gly Ala 
        195                 200                 205             


Ala Ala Ala His Ala Gln Ser Val Pro Leu Val Val Arg Ser Ala Pro 
    210                 215                 220                 


Pro Pro Glu Ala Pro Arg Ser Leu Thr Ala Arg Gly Arg Thr His Ala 
225                 230                 235                 240 


Asp Ala Gln Ala Ala Val Ala Gln Ala Gln Ser Gly Arg Leu Pro Gly 
                245                 250                 255     


Ile Gly Ala Phe Tyr Pro Ser Val Ser 
            260                 265 


<210>  5132
<211>  798
<212>  DNA
<213>  Homosapiens

<400>  5132
atgggtgctt tagaagaagg cttcattgtg cccttctcct ctgactctga tgcacatttt     60

gatgctgcgg ttggatattt agaggacatt atcatggatg aagatttcca gttattacag    120

agaaatttca tcaacaacta ctaccaggag tttgaggaca ccaaagagaa taaactcacc    180

tacacaccta tttttaatga atatatttct ttggcaggaa agtatataga agaacagtat    240

atagaagaaa aacagttgct ggagcaaatt cttggcttta ccatggcaac tttcacaacg    300

ttacagcacc acaaagatga agtggttggt gacatactcc aaatgctgct caaatttaca    360

gattttctgg cttttaaaga aatgtttctg gactgcagag cagaaaaaga aggccagaga    420

ctggacttaa gccgtggttt agtggagact tcattgtgca aatcatcttc tatgacagct    480

tctcagaaca atctgcagca caaccagtta ccatcagttg gcgctagcac accaccgact    540

gcaggcttta ctgatgagga aactgaggct cggagaggct gtcacgaact tgctgtagtc    600

acacaggaac tggccgaagg ggccgcggcc gcacatgcgc agtcagtccc gttggttgtg    660

cgctcagccc cgcccccaga ggcgccgcgc tccctgacag cccgcgggcg tacacacgct    720

gacgcgcagg ctgcggtcgc gcaggcgcag tcggggcgcc ttcccggtat aggcgccttt    780

taccccagcg tgtcctga                                                  798


<210>  5133
<211>  265
<212>  PRT
<213>  Homosapiens

<400>  5133

Met Gly Ala Leu Glu Glu Gly Phe Ile Val Pro Phe Ser Ser Asp Ser 
1               5                   10                  15      


Asp Ala His Phe Asp Ala Ala Val Gly Tyr Leu Glu Asp Ile Ile Met 
            20                  25                  30          


Asp Glu Asp Phe Gln Leu Leu Gln Arg Asn Phe Ile Asn Asn Tyr Tyr 
        35                  40                  45              


Gln Glu Phe Glu Asp Thr Lys Glu Asn Lys Leu Thr Tyr Thr Pro Ile 
    50                  55                  60                  


Phe Asn Glu Tyr Ile Ser Leu Ala Gly Lys Tyr Ile Glu Glu Gln Tyr 
65                  70                  75                  80  


Ile Glu Glu Lys Gln Leu Leu Glu Gln Ile Leu Gly Phe Thr Met Ala 
                85                  90                  95      


Thr Phe Thr Thr Leu Gln His His Lys Asp Glu Val Val Gly Asp Ile 
            100                 105                 110         


Leu Gln Met Leu Leu Lys Phe Thr Asp Phe Leu Ala Phe Lys Glu Met 
        115                 120                 125             


Phe Leu Asp Cys Arg Ala Glu Lys Glu Gly Gln Arg Leu Asp Leu Ser 
    130                 135                 140                 


Arg Gly Leu Val Glu Thr Ser Leu Cys Lys Ser Ser Ser Met Thr Ala 
145                 150                 155                 160 


Ser Gln Asn Asn Leu Gln His Asn Gln Leu Pro Ser Val Gly Ala Ser 
                165                 170                 175     


Thr Pro Pro Thr Ala Gly Phe Thr Asp Glu Glu Thr Glu Ala Arg Arg 
            180                 185                 190         


Gly Cys His Glu Leu Ala Val Val Thr Gln Glu Leu Ala Glu Gly Ala 
        195                 200                 205             


Ala Ala Ala His Ala Gln Ser Val Pro Leu Val Val Arg Ser Ala Pro 
    210                 215                 220                 


Pro Pro Glu Ala Pro Arg Ser Leu Thr Ala Arg Gly Arg Thr His Ala 
225                 230                 235                 240 


Asp Ala Gln Ala Ala Val Ala Gln Ala Gln Ser Gly Arg Leu Pro Gly 
                245                 250                 255     


Ile Gly Ala Phe Tyr Pro Ser Val Ser 
            260                 265 


<210>  5134
<211>  700
<212>  DNA
<213>  Homosapiens

<400>  5134
atgaggtgta aaaacctggg cgttggagaa aggcagcctg gaggggatag tctgtgtgtc     60

cctcaggttc ctcaacccgc catcggggcc aactggaggt atgactttcc tgcacacagg    120

agcaagctga aaactgccct gtggctttat tccacgttca cccctgcagc aaatgccttt    180

tctgtgagga actacgggct gatggggaat cagaggtggt tcttcctaag tggcgtttct    240

gagtgggttc caggagtcca caaggcggga accgagccgc aggccgctgc gaggagtact    300

accccgccac ccccgcgccg cgagtttccg cgcacgtggc cgtggggccg gtctcgctcc    360

cgccccccgc cgggcccgcg cagccccctc ctctgcggct cccggagcgg ccagagcgcg    420

cggcggcggg cgggggcggg ccgcaagcag ggctccctgg ccgctttcca ggtcggcgca    480

ctaatacggg cgatgaggct tcgcggctcc agtctgactg acgccggctg gggccgccgc    540

cgccgccgcc gccgccgccg ctgctgcagc cgctgtctcg gtccccgccg ccgccgccgg    600

gccctgcagg cgctgggcgc gcgcagccag gcaagttggc caccctgttc aagggcttag    660

gagaaagtca acacacttcg caacttgaat tggtcccagc                          700


<210>  5135
<211>  219
<212>  PRT
<213>  Homosapiens

<400>  5135

Met Arg Cys Lys Asn Leu Gly Val Gly Glu Arg Gln Pro Gly Gly Asp 
1               5                   10                  15      


Ser Leu Cys Val Pro Gln Val Pro Gln Pro Ala Ile Gly Ala Asn Trp 
            20                  25                  30          


Arg Tyr Asp Phe Pro Ala His Arg Ser Lys Leu Lys Thr Ala Leu Trp 
        35                  40                  45              


Leu Tyr Ser Thr Phe Thr Pro Ala Ala Asn Ala Phe Ser Val Arg Asn 
    50                  55                  60                  


Tyr Gly Leu Met Gly Asn Gln Arg Trp Phe Phe Leu Ser Gly Val Ser 
65                  70                  75                  80  


Glu Trp Val Pro Gly Val His Lys Ala Gly Thr Glu Pro Gln Ala Ala 
                85                  90                  95      


Ala Arg Ser Thr Thr Pro Pro Pro Pro Arg Arg Glu Phe Pro Arg Thr 
            100                 105                 110         


Trp Pro Trp Gly Arg Ser Arg Ser Arg Pro Pro Pro Gly Pro Arg Ser 
        115                 120                 125             


Pro Leu Leu Cys Gly Ser Arg Ser Gly Gln Ser Ala Arg Arg Arg Ala 
    130                 135                 140                 


Gly Ala Gly Arg Lys Gln Gly Ser Leu Ala Ala Phe Gln Val Gly Ala 
145                 150                 155                 160 


Leu Ile Arg Ala Met Arg Leu Arg Gly Ser Ser Leu Thr Asp Ala Gly 
                165                 170                 175     


Trp Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys Cys Ser Arg Cys 
            180                 185                 190         


Leu Gly Pro Arg Arg Arg Arg Arg Ala Leu Gln Ala Leu Gly Ala Arg 
        195                 200                 205             


Ser Gln Ala Ser Trp Pro Pro Cys Ser Arg Ala 
    210                 215                 


<210>  5136
<211>  3493
<212>  DNA
<213>  Homosapiens

<400>  5136
agaccggaaa cggaggagag cgcgggggat gtgtttggca tggggacgca ctgttacagt     60

tgcgctcctg gttggctttg tgtttccgcg gtgttggtag agtctcggtg tttctacctc    120

ttagcaccct ttcctgccac cctttgtcct gtggaagccc ggagacatca gcggctgcaa    180

ttttgctact cgctgctcgg catggaacgg tcaggtaccg cagttcagcg ctcttggccc    240

cgcaggtcct cgggcatccc cgtgccccgt gctgtacatt cagttatcct ccgacttccc    300

ggggtcgaag gtattacctg ctgggtttta gaatctattg ctttacatct gagaaaagaa    360

aaatcccaga aagataagat gacttgccca agatcatagc gtgcctggaa gacagtgctc    420

cgattacaag ctggtcgctg tgcctcattc gtcttgtcat caactcctgt cagtttatcc    480

aagctccaaa agcgaagttg ttttagcttt tgcttcccaa gatttatttg atagtctcat    540

ttctgtttcc ttcgtttatt ctttcgttca ttattggaaa actttacagc gtgccagtac    600

tggtcataaa ccccagtgtg tcttaggcct tagtgagctg tgaggtgcat gaccttaggt    660

aagttacttc tctgattttc agtttcctta tctgcaaaat ggagacctta gggagttaat    720

gtgggtatga gaaatgtaca taaaacatat tgcacaaggt gaggcatgta gtgtatgcta    780

ataaatggta agttgctgct gctatggttg ttaacaataa ttataaaaag caaatggaaa    840

aggcttgaat tgaaaaaaat ttagacacat agtttttttc cttattagcc tgcactgtat    900

ttttcatttt ttttaatgca tctttccagg acaaaaaata atatccaaag atattttggc    960

actaacagcg ctatctgtag caagaaagtt gagcagtgtg aactgttgag acttccaaga   1020

agacttcaga gaaccaagac agtgtaaagg aaaacaggaa aaaagacttg ttagacatta   1080

ttaagggcac gaaagttgaa ttgagcacag taaatgtaca aacaacaaag ccacccaaca   1140

gaagtccact taaaagctac aactggcccg cctcaaagag ctacagagca tgctccaaag   1200

aagagaaatg agcccgtgag tcctgagttg gtggcagctg catctgctgc tctgttttga   1260

caagcaaaca agccagaact gctcaggcag ctccgtagca tgaggaggag tcaggggcac   1320

agagagatgg agagagacct agttagagag cgaaccatgt gctggattta gccagtcctg   1380

catttttcta tacttcaaat caaaacgggc catgcttcac atctacccat gatgaatagg   1440

ggtactttga ttaagaataa atagagctga ctgaattctg aacaagaaaa acatattcaa   1500

ggggaagaga tgtaatagtt ttgacgtgac gacagttact aaagaagcac ctgaacagac   1560

acatcacctt cactttggga tgtggaattt gctaaataag ccacagaaaa tgaacatccc   1620

ttcagaatgg gtttgaagag ctgatccagt ggattaaaga ggggaaactg ggagtttcca   1680

gttaacaatg aagcaggagc tgactaaggc tttggaacag aaaccagatg atgcacaata   1740

ttattgtcaa agagcttatt gtcacattct tcttgggagt tactatggat ctgtaaataa   1800

ctgacgaaaa acccatctgt ttctacgtag ttgctgttgc cgacacaaag aagtcttatg   1860

aactcaatcc aaataattcc actgctatgc tgagaaaagg gggctggcgg catggagtct   1920

tgctctgtca cccatcctcg agtgcaatgg caccatctta gttcactgca gccttgaatt   1980

ccagggctcg agccatcctt ctgcctctgc ctcctgagta ggtgggacta caggcatgtg   2040

ccaccatact gagctaattt gttaaacact ttttttgtag agacgaggtc ttgctacgtt   2100

tcccagactg gtctctgaac tcccggcctc aagtgatcct actgccttgg cctcccaaag   2160

tactggcata atagacatga gccactgcac ctggctccta agttcttttc ttgaataata   2220

tctttctttt tttttatttt ttgaggtgga gtctcaccct gttgcccagg ctggagtgca   2280

atggcgtgat ctcggctcac tgcaacttct acctcccggg ttcaagtgat tctcctgcct   2340

cagcctcctg aatagctagg attacaggcg tgcgctacca cgcctggcta attttttgtg   2400

tctttagtag agatgcggtt tcaccatgtt ggccaggctt gtctcgaact cttgacctcg   2460

tgatccaccc gccttggcct cccaaagtgt tgggattaca ggcgtgagcc accacgcctg   2520

gccaagtaat atcttaatat catgccattg acatttatcc tctaattatt tcagaggtgg   2580

ccttcagaag aaggcctctt tggtaaaatt gctattgagg atatttcact gaaaaacaaa   2640

tttatcttta aatttaaatc caggaaaaat ttaaactttc aggcttctat ttttatcaga   2700

cagggtaaaa aatttataac tcagaatatt accctttccc ctctttgtgt gatggattgc   2760

ttggttttag ttactgatta tttaaaataa taagttattc aaatctagga ttttgataca   2820

atagttcttc tctagaatat agtgtgtgtg tgagagtata tttaaaattt ttattaaggc   2880

ccatggggca gcctttgagg aaaccagacc ttggggatcg ccaggcagga ttagtggcag   2940

gaattgagag aacagagccc cacagagctc ctcggggacc gtcccccagt cacaagagta   3000

tctcaaggaa gtagtcttct cccacatccc ccaaagataa ctaccagagg gtcagttctc   3060

tgagcccttc tcagtgtaga aaagacaagt gtcaaagctt ccccactcac cctgagtttg   3120

ccttctatga caatacgtcg tttggcctca ctgaggctga gcagaggatg ctggacctcc   3180

caggatattt tgggtcaaat gaagaggatg aaaccacaag tacacttagc gtggagaagc   3240

tggtgatcta gactgagaat cagcctgagc ttaacacagc tggggtctgc tactcgcgtt   3300

ttgtagactt ttgtgtaact atttgtaccg taggacagaa tgtgaggagg aagtaacaca   3360

cacagaggag gatgtgtgtg tgtgcatgtg tttgaattca caaggaagaa attatttatc   3420

ttgagctttt tcctttgtta ttcagttttt attggtttat tactaataat gataataaaa   3480

tgtaaacaag agc                                                      3493


<210>  5137
<211>  2601
<212>  DNA
<213>  Homosapiens

<400>  5137
agctctgctc aggcttcaac atggcgggcc gtttcggttg acttcgcctg tggaaaccga     60

attccccctc catggtttcc ccaggatatg agttgggggc ctcacctcgc ctataagggt    120

caggcgagct ttctggatgc tcgagggacc tttcggcctg cgcagccgga gcagcttgtc    180

ccaatgccct gccatttctg tgagggccca cgaggcctgg aggagcctcg gagcccccgc    240

aggccctcgc gtcactgcct caagagggtg ctcggagccc tgctcgggag ctggtcccca    300

acgaggtgtg gaaccccttc ttgctggaac tccacggaga gactgtcctg ctaggacctg    360

cttccagaag agttgatccc agccgtgaaa gtgcatgatg ccttcagcga agcaggcagg    420

aaaggctcaa gtgatcctcc tgtatcaccc tgggtatcaa ggccattcag tggaaaagaa    480

cagtctcttc agcaagtgga tgaagttaga tctcttcctc acatcataca gaaaaatcag    540

cctcaaatgg aagaaatatc taaatgaagc cgaacacttg ataaaaagtt catcagcgta    600

aataagaaga atcccctcca ttacatacaa aagaaaaaat aactggagag atcgtctctg    660

ctctaagcgt gtttttaagt ctctgcagtc ttggaccaag ctcgttttat tccctactct    720

aggagaatct cagagcacca ggattctgtt tggggttgcc atggacacag agttcttaat    780

ccagtactgg cttattctca atacgagaga aggttgtact gaagacacga gacctgagac    840

ttgtgtcatt ttagcggctg aaccgacccc aacttcttct gagcggcagt ggcgccagaa    900

gcagtctggc tttcagtccc catcctgttg acctggtgga agtcatcatt gatagagaca    960

cccatgacat tccccacaca agtgaactga caggaggaac caaggaggca cgtatctacg   1020

aaaatgtgtc agaacgactt tccaggtttg aagattatga aaatgctgaa tatgtcgctt   1080

catatgacag caggattaag aaaattgttc attcaattgt gtcatccttt gcagttggaa   1140

tatttggagt tttcctgatc ttgttggatg tggctctgat ctttgctgac ctaattttca   1200

ctgatagcaa agtttatatt cctttggagt atcattctat ttctctagct attgctttat   1260

tttttctcat ggatgttctt cttcgagtat ttgtagaagg gagacagcat tatttttctg   1320

atttacttaa cattttagat actgctgtta ctgtgattat tctgctggtt gatgtcgttt   1380

acattttttt tgacgttaag tttcttaagg atattcccag atggacacgt ttatttcgac   1440

ttctacgact tatcattctg ataagagttt ttcatctggc tcatctaaaa agacaacttg   1500

gaaagctgat aagaaggctg gtttcaggaa acaaaaggtg atacgaaagt gatggatttg   1560

acctagacct cacttatatt acagaacata ttgtcgctat gtcgtttcca tcttcgggag   1620

gccagtcttt ctatcggaat ccaattaagg tgaaagagct tatgatccta agcacttcca   1680

taatagggtc agtagaatca tgatcgatga tcataatgtc cccactctac gggagatggt   1740

agcattctcc aaggaagtgt tggagtggat ggctcaagat tctgaaaaca tcgtagtgat   1800

tcactgtaaa ggaggcaaag gaagaaccgg aactatggtt tgtgcctgcc tgattgccag   1860

tgaaatattt ttaactgcag aggaaagatt gtactatttt ggagaacggc gaacagataa   1920

aaccaatggc actaaatatc agggagtaga aactccttct cagaatagat atgttggata   1980

ttttgcacaa gtgaaacata gctacaactg gaatctccct ccaagaaaaa cactgtttat   2040

aaaaagattc gttatttatt cgattcatgg tgttggaaca ggcgatggat atgatctaaa   2100

agtccaaata gtaatgaaga aaaagattgt cttttcctgt acttccttaa agaattgtcg   2160

ggtatttcat gacactgaaa cagacagggt aataactgat gtgttcaact gtccacctct   2220

gtatgatgat gtgaaagtgc aagcttcctc ttcagatttt cctaaatact atcacaacta   2280

cccttttttc ttctggttta acacatcttt aatacaaaat aacgggcttt atctacaaag   2340

aaatgaattg gataatcttc ataaacaaaa aacatggaaa atttatcaac cagaatatgc   2400

agtagagata tattttaatg agaaatgact taagttatgt tgtaactggt agctgattaa   2460

gtatagttcc ctgcacccct tctgggaaag aattatgttc tttctaaccc tgccacatag   2520

ttatatgttc taaatcttcc ttgctggtac atctatattg atatatgtat acacatgttc   2580

tttataaatc tattaaatat a                                             2601


<210>  5138
<211>  242
<212>  PRT
<213>  Homosapiens

<400>  5138

Met Ile Asp Asp His Asn Val Pro Thr Leu Arg Glu Met Val Ala Phe 
1               5                   10                  15      


Ser Lys Glu Val Leu Glu Trp Met Ala Gln Asp Ser Glu Asn Ile Val 
            20                  25                  30          


Val Ile His Cys Lys Gly Gly Lys Gly Arg Thr Gly Thr Met Val Cys 
        35                  40                  45              


Ala Cys Leu Ile Ala Ser Glu Ile Phe Leu Thr Ala Glu Glu Arg Leu 
    50                  55                  60                  


Tyr Tyr Phe Gly Glu Arg Arg Thr Asp Lys Thr Asn Gly Thr Lys Tyr 
65                  70                  75                  80  


Gln Gly Val Glu Thr Pro Ser Gln Asn Arg Tyr Val Gly Tyr Phe Ala 
                85                  90                  95      


Gln Val Lys His Ser Tyr Asn Trp Asn Leu Pro Pro Arg Lys Thr Leu 
            100                 105                 110         


Phe Ile Lys Arg Phe Val Ile Tyr Ser Ile His Gly Val Gly Thr Gly 
        115                 120                 125             


Asp Gly Tyr Asp Leu Lys Val Gln Ile Val Met Lys Lys Lys Ile Val 
    130                 135                 140                 


Phe Ser Cys Thr Ser Leu Lys Asn Cys Arg Val Phe His Asp Thr Glu 
145                 150                 155                 160 


Thr Asp Arg Val Ile Thr Asp Val Phe Asn Cys Pro Pro Leu Tyr Asp 
                165                 170                 175     


Asp Val Lys Val Gln Ala Ser Ser Ser Asp Phe Pro Lys Tyr Tyr His 
            180                 185                 190         


Asn Tyr Pro Phe Phe Phe Trp Phe Asn Thr Ser Leu Ile Gln Asn Asn 
        195                 200                 205             


Gly Leu Tyr Leu Gln Arg Asn Glu Leu Asp Asn Leu His Lys Gln Lys 
    210                 215                 220                 


Thr Trp Lys Ile Tyr Gln Pro Glu Tyr Ala Val Glu Ile Tyr Phe Asn 
225                 230                 235                 240 


Glu Lys 
        


<210>  5139
<211>  511
<212>  DNA
<213>  Homosapiens

<400>  5139
ttccttgtgt cttttcctca caaagtctcc aagtctctcg ttaaattagc tccaggactt     60

gggagaaaca gtgcccttcc tcggtccggg ttgcttggat ccccagtgga aaggaagaac    120

cggaactatg gtttgtgcct gcctgattgc cagtgaaata tttttaactg cagaggtgtt    180

ggaacaggcg atggatatga tctaaaagtc caaatagtaa tgaagaaaaa gattgtcttt    240

tcctgtactt ccttaaagaa ttgtcgggta tttcatgaca ctgaaacaga cagggtaata    300

actgatgtgt tcaactgtcc acctctgtat gatgatgtga aagtgcaagc ttcctcttca    360

gctttatcta caaagaaatg aattggataa tcttcataaa caaaaaacat ggaaaattta    420

tcaaccagaa tatgcagtag agatatattt taatgagaaa tgacttaagt tatgttgtaa    480

ctggtagctg attaagtata gttccctgca c                                   511


<210>  5140
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  5140

Met Lys Lys Lys Ile Val Phe Ser Cys Thr Ser Leu Lys Asn Cys Arg 
1               5                   10                  15      


Val Phe His Asp Thr Glu Thr Asp Arg Val Ile Thr Asp Val Phe Asn 
            20                  25                  30          


Cys Pro Pro Leu Tyr Asp Asp Val Lys Val Gln Ala Ser Ser Ser Ala 
        35                  40                  45              


Leu Ser Thr Lys Lys 
    50              


<210>  5141
<211>  234
<212>  DNA
<213>  Homosapiens

<400>  5141
atgcctgagc ccccgccccg cggtgggctc ccgcgcactg cccgagcatc ccctacaggt     60

gccaccccct gctctgcaga gcccggtcct atcaaccacc caagggctga ggagtgcggt    120

ggcacagcgc gggactggcg ggtagctcca cccgcggacc tggtgctgga tccactaggt    180

gaacccagct gggctcctca gtctggtgga gacttggaga acttttatat ctag          234


<210>  5142
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  5142

Met Pro Glu Pro Pro Pro Arg Gly Gly Leu Pro Arg Thr Ala Arg Ala 
1               5                   10                  15      


Ser Pro Thr Gly Ala Thr Pro Cys Ser Ala Glu Pro Gly Pro Ile Asn 
            20                  25                  30          


His Pro Arg Ala Glu Glu Cys Gly Gly Thr Ala Arg Asp Trp Arg Val 
        35                  40                  45              


Ala Pro Pro Ala Asp Leu Val Leu Asp Pro Leu Gly Glu Pro Ser Trp 
    50                  55                  60                  


Ala Pro Gln Ser Gly Gly Asp Leu Glu Asn Phe Tyr Ile 
65                  70                  75          


<210>  5143
<211>  861
<212>  DNA
<213>  Homosapiens

<400>  5143
atgactatag atgttaagat cactttaaaa tatcaaaatg actgcatcag ccaaaagctc     60

cacatcttat ttgtacgttg taaatttagg ggccgatttt ccattcggct gcggggagcc    120

tggggcgacg gctgtccggt acggggtccc tccggttccg cggcggcgga gcctctaggc    180

ctcacggccg gacccgaacc tcagcgttcc ggtggcggcg gcggcctcac gatcctcccc    240

cgcgggcccg tcccatcaaa tcggcaccga ccccgttgcg gctccgccgg tggctcctcg    300

ctcacattcc tggcgggcgg cgcctcagct cgttgccccg gacccggcgg cggcggcgac    360

gaccctttgg gcggcggtcg tcttggaccg gaggattcca agggctcggg tcgtctaagg    420

gtcggggagc cccggagact tgatcccgcc ctgcagctag tgtggcccct cagggtttgg    480

ggagtcccac tctggacggg accctgtgat gcgatcgctc ttgcaaagaa ggatggcaag    540

aagaagagcc tttctgccat cagcattcac aagcgcatcc atggtgtggg cttcaagaag    600

tgtgcccctc gggcactcga agagatccaa aaatgtgcca tgaaggagat gggcactcca    660

gatgtgcaca ttgatactag gctcaacaaa gctgtttggg ccaaaggaat aaggattgtc    720

ccataccgta tccctgtgtg gttgtccaga aaacgtaacg aggatgaaaa ttcaacaaac    780

aagctctata ctttggttac ccatgtacgt gttaccgttt tcaaaaatct acagtcaatg    840

tggatgagaa ctaaccactg a                                              861


<210>  5144
<211>  286
<212>  PRT
<213>  Homosapiens

<400>  5144

Met Thr Ile Asp Val Lys Ile Thr Leu Lys Tyr Gln Asn Asp Cys Ile 
1               5                   10                  15      


Ser Gln Lys Leu His Ile Leu Phe Val Arg Cys Lys Phe Arg Gly Arg 
            20                  25                  30          


Phe Ser Ile Arg Leu Arg Gly Ala Trp Gly Asp Gly Cys Pro Val Arg 
        35                  40                  45              


Gly Pro Ser Gly Ser Ala Ala Ala Glu Pro Leu Gly Leu Thr Ala Gly 
    50                  55                  60                  


Pro Glu Pro Gln Arg Ser Gly Gly Gly Gly Gly Leu Thr Ile Leu Pro 
65                  70                  75                  80  


Arg Gly Pro Val Pro Ser Asn Arg His Arg Pro Arg Cys Gly Ser Ala 
                85                  90                  95      


Gly Gly Ser Ser Leu Thr Phe Leu Ala Gly Gly Ala Ser Ala Arg Cys 
            100                 105                 110         


Pro Gly Pro Gly Gly Gly Gly Asp Asp Pro Leu Gly Gly Gly Arg Leu 
        115                 120                 125             


Gly Pro Glu Asp Ser Lys Gly Ser Gly Arg Leu Arg Val Gly Glu Pro 
    130                 135                 140                 


Arg Arg Leu Asp Pro Ala Leu Gln Leu Val Trp Pro Leu Arg Val Trp 
145                 150                 155                 160 


Gly Val Pro Leu Trp Thr Gly Pro Cys Asp Ala Ile Ala Leu Ala Lys 
                165                 170                 175     


Lys Asp Gly Lys Lys Lys Ser Leu Ser Ala Ile Ser Ile His Lys Arg 
            180                 185                 190         


Ile His Gly Val Gly Phe Lys Lys Cys Ala Pro Arg Ala Leu Glu Glu 
        195                 200                 205             


Ile Gln Lys Cys Ala Met Lys Glu Met Gly Thr Pro Asp Val His Ile 
    210                 215                 220                 


Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Ile Val 
225                 230                 235                 240 


Pro Tyr Arg Ile Pro Val Trp Leu Ser Arg Lys Arg Asn Glu Asp Glu 
                245                 250                 255     


Asn Ser Thr Asn Lys Leu Tyr Thr Leu Val Thr His Val Arg Val Thr 
            260                 265                 270         


Val Phe Lys Asn Leu Gln Ser Met Trp Met Arg Thr Asn His 
        275                 280                 285     


<210>  5145
<211>  485
<212>  DNA
<213>  Homosapiens

<400>  5145
aaaatgatat tcattgtcct aatgtgtaaa tttcgacaat ttgcaaattt gtagattctt     60

tagaatagaa ctaactcaag cccttcattc tgcagctgag gctcactgcc cccagtgggc    120

agtgggtcca gggggtttct gaggacaggg catgacccag ccctgctgcc cccaagatgg    180

cacctggctt ggaggggtga ggggccctgt tagtctgact ttgaagaaga ccagccttcc    240

agactcgctt ggtgccctga caggagccct gggctccccc agtgttgcct gggtctgact    300

ttgcctcagt gaaaactgcc tcgaattctt tcttgcaccg atgggcagat gggcagtgtc    360

ggaggatcgt gtcatctgtc ccgtggcgct ggttggcttg gtcaagtcag tgttcaaact    420

atctcctgct ctttcaaggg gatctggggc tctagaagat tagaggactt ggagaggtta    480

gtgac                                                                485


<210>  5146
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5146

Met Gly Arg Trp Ala Val Ser Glu Asp Arg Val Ile Cys Pro Val Ala 
1               5                   10                  15      


Leu Val Gly Leu Val Lys Ser Val Phe Lys Leu Ser Pro Ala Leu Ser 
            20                  25                  30          


Arg Gly Ser Gly Ala Leu Glu Asp 
        35                  40  


<210>  5147
<211>  1611
<212>  DNA
<213>  Homosapiens

<400>  5147
atcatgatta atccagttct gcacaaaaca ctgaggtcca ttagaagaca ataggtcttg     60

gctgtttcat tccttttaag agctgtttaa tattccacgg agccctgggc tcccccagtg    120

ttgcctgggt ctgactttgc ctcagtgaaa actgcctcga attctttctt gcaccgatgg    180

gcagatgggc agtgtcggag gatcgtgtca tctgtcccgt ggcgctggtt ggcttggtca    240

agtcagtgtt caaactatct cctgctcttt caaggggatc tggggctcta gaagattaga    300

ggacttggag aggttagtga cttgctcgag gtcggctagg aagcaagacc caggattcca    360

actcaggtct gtgtgattcc tctgcaaaat ggagaggtgg aaggatggat gtcaggtctg    420

atggatggat ggatgcctac atcaagatac atgcatagat ggagagatgg ctggctacct    480

catgaatgct ggactgttgt gagaatcaaa cgagataatg tatgctgagg catgctgtga    540

acactacgtg ctgggtacag gagaatggag gctccagagt gaaattaatg acactttgtc    600

gatgaagatc ttgattgtga cctctgtgga aaatgagcca tgaaccaacc aatatgaaaa    660

ataaaagaaa tctacatgga tcccactttg gacaaagtgc gtgtcaacag ttgcatgaaa    720

tggtatttca cttcttgatt attgtttgtt tttattcttt ttttagaaaa aatgaataaa    780

tgatcaaatt attttggggg taattaaata aaagaaagaa cacaagtgag tcagtaaatg    840

cttaaattaa ggtagatctt ggatcattgc ttcatggcac actctcagaa atgctcaaat    900

atggtgcctt aaaaaaatta atgaggtttg ggtgttgatg tggttaggga gtatacagat    960

agatagttgt tagtggttac atttattact cttgcattgg gtggatttaa gggttcatta   1020

tattaagaat taaacagtaa gtaaattcat acataaaagg tatggttatt cttgagtcaa   1080

taatgagaat gtgttaggaa ccaaggttta tgattaatct aaaataattt ctaaaagaag   1140

ttaagtcttt gctgtttcgt tctttctaaa atgtgtattt tccttcacac aatgaacatg   1200

ccacagctaa ttattcgata acaataaaga cattggtgtt ttgcctctgt ggttaaggag   1260

ctcagagtct gttgtagata atagttaaag ttcatgtcct gggtttaggt ggcttgttca   1320

tcactaaatt atgttagaag aataaaccgc taaatatata catatataaa aagcatacca   1380

tacaagaacc aataatggaa gtgaaccaag gtttatgatt agtttaattc agcccaactt   1440

aggtccatta caaatgatgg agggctttta ttaatttcag aggtttttaa tattgtattt   1500

tattttgtgc cgtggttgat ttacacacat ttctttaaag ttaaagatca aggctattca   1560

ctcctctagg gagaagcaga taggaaaagg aagatagtgt cagtgtcctc a            1611


<210>  5148
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5148

Met Gly Arg Trp Ala Val Ser Glu Asp Arg Val Ile Cys Pro Val Ala 
1               5                   10                  15      


Leu Val Gly Leu Val Lys Ser Val Phe Lys Leu Ser Pro Ala Leu Ser 
            20                  25                  30          


Arg Gly Ser Gly Ala Leu Glu Asp 
        35                  40  


<210>  5149
<211>  1498
<212>  DNA
<213>  Homosapiens

<400>  5149
atcatgatta atccagttct gcacaaaaca ctgaggtcca ttagaagaca ataggtcttg     60

gctgtttcat tccttttaag agctgtttaa tattccacgg agccctgggc tcccccagtg    120

ttgcctgggt ctgactttgc ctcagtgaaa actgcctcga attctttctt gcaccgatgg    180

gcagatgggc agtgtcggag gatcgtgtca tctgtcccgt ggcgctggtt ggcttggtca    240

agtcagtgtt caaactatct cctgctcttt caaggggatc tggggctcta gaagattaga    300

ggacttggag aggttagtga cttgctcgag gtcggctagg aagcaagacc caggattcca    360

actcaggtct gtgtgattcc tctgcaaaat ggagaggtgg aaggatggat gtcaggtctg    420

atggatggat ggatgcctac atcaagatac atgcatagat ggagagatgg ctggctacct    480

catgaatgct ggactgttgt gagaatcaaa cgagataatg tatgctgagg catgctgtga    540

acactacgtg ctgggtacag gagaatggag gctccagagt gaaattaatg acactttgtc    600

gatgaagatc ttgattgtga cctctgtgga aaatgagcca tgaaccaacc aataagcagg    660

cttagtcacc cttgacacag tttgcagtta tccacctcct ccaagttctt aatatgttag    720

atccagataa ctgccttgta cagccacctc caggatactg cctccctaaa aaacagctag    780

atacactgac cccacagcct atgtggacca cacagatata gtggcttgct ctaaatgcac    840

cagtgagaac tctctgcagg aaacctgctt gggaaatgcc atagcctgca atacaggctt    900

tccccttccc gctggccctg tgaggcatgc aggatctgta agtaataaac tgcttctgtt    960

gtttcatttc atgtgttttg ttgagttgct tcctctgtgt ctcacctgac caacacactt   1020

gaattgaact tctttcctgg tcagggatct cctagagaat ggctatcttg gcaggaatag   1080

actagatgta ggtcagacaa gaaccacagg ggtactgcca gtgtaaatga gtttcctatg   1140

agagggacac ctggtaatgg ataggatgct taggcattag actgtctgct gggataaaga   1200

cgtatcccat aaaagatacg ctgtaaacac ccatgaccac ctctcctgca tccccatcag   1260

gcagagctag aatttatatt cactctcttg agacagacct caagaccatg ttagaagaaa   1320

gtacaacact catcatccta gaattatgat tattccaatt cagttcatcc aaggtccctt   1380

taaaaatgca ttggttaaag agtcagttaa tattcttttt tttggcatgg tggcatgttg   1440

gatgttgatt ttagtactaa aaataaataa ataattacct aagtgtgtaa aataaaca     1498


<210>  5150
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5150

Met Gly Arg Trp Ala Val Ser Glu Asp Arg Val Ile Cys Pro Val Ala 
1               5                   10                  15      


Leu Val Gly Leu Val Lys Ser Val Phe Lys Leu Ser Pro Ala Leu Ser 
            20                  25                  30          


Arg Gly Ser Gly Ala Leu Glu Asp 
        35                  40  


<210>  5151
<211>  547
<212>  DNA
<213>  Homosapiens

<400>  5151
tcatggagga ctgttttatc tgtttgtgat ctgccgtcct ctgtgagcct caggatggat     60

gtttgccagc cgattccatg gttacaagct ctatagctgc atctatgtgt taggagcatg    120

aagaccaata atggatgcac tgagctgatt atgaatttag ccctgatgaa gacttgtgtt    180

gctgtcatga tatgaaagat tccagtaatg aacgcacttg agttgattca agcacgcttc    240

catggtcatg agctctgtgg ttgcatctgt gtgttaggag catgcagacc aatagtgata    300

atctcgaggt gatttatgca ttcttccatg gccaccagcc ttatgattgc atctgtgcgt    360

cacagcttag agatcaataa tggatgcaac aagctctttg aatcattctg ttgggatcaa    420

gattgttgtg ttccctctgt ttggaaagag accaagaatg gatacgctca ggtgatttaa    480

gcagtcttcc atggccacga gctctgtggt tgcctctgta tattaagagc acagagatta    540

aaaatgg                                                              547


<210>  5152
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  5152

Met Ala Thr Ser Leu Met Ile Ala Ser Val Arg His Ser Leu Glu Ile 
1               5                   10                  15      


Asn Asn Gly Cys Asn Lys Leu Phe Glu Ser Phe Cys Trp Asp Gln Asp 
            20                  25                  30          


Cys Cys Val Pro Ser Val Trp Lys Glu Thr Lys Asn Gly Tyr Ala Gln 
        35                  40                  45              


Val Ile 
    50  


<210>  5153
<211>  648
<212>  DNA
<213>  Homosapiens

<400>  5153
tttctcagtg ccttgcagag agaggagtag cttgctggct ttgaacgcgt ggcgtggcag     60

atatttcaga aagcttcaag aacaagctgg agaagggaag agttattcct ccatattcac    120

ctgcttcaac tactattctt attgggaatg gacaatggaa tgttctctgg ttttatcatg    180

atcaaaaacc tccttctctt ttgtatttcc atgaacttat ccagtcactt tggcttttca    240

cagatgccaa ccagttcagt gaaagatgag accaatgaca acatcacgat atttaccagg    300

atcttggatg ggctcttgga tggctacgac aacagacttc ggcccgggct gggagagcgc    360

atcactcagg tgaggaccga catctacgtc accagcttcg gcccggtgtc cgacacggaa    420

atggagtaca ccatagacgt gtttttccga caaagctgga aagatgaaag gcttcggttt    480

aaggggccca tgcagcgcct ccctctcaac aacctccttg ccagcaagat ctggacccca    540

gacacgttct tccacaacgg gaagaagtcc atcgctcaca acatgaccac gcccaacaag    600

ctgctgcggc tggaggacga cggcaccctg ctctacacca tgcggtga                 648


<210>  5154
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  5154

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr 
145                 150                 155                 160 


Leu Leu Tyr Thr Met Arg 
                165     


<210>  5155
<211>  1071
<212>  DNA
<213>  Homosapiens

<400>  5155
atgtgctggg cagaggagga tgagaatgcc agaaagagtc ctggaaaggc ggggagctgg     60

cacagcgcac acagccccgg cctgggcacc cgcgcccgct cgcggctcca ggcggggtgg    120

gcggcgccgc gccagggggt ccccggcgcc cattgctccc gccgcccggt tgcgcggacc    180

ggcgctagtg cgcgggtggg ggcggcgcgc cgcggtggcc cggcgtcccg tgtgcgtcca    240

gtgtgcgccc cgcgggggcg cggccagcgc cagagtagat acctgtcccg cccgccgcgg    300

ccagcagcct cggaggaagc cagggcaaag agggccggcg gagaccaggt ccgcgccgga    360

ggaagccgcg cccggccgag gccccggacc ctgcgccccg agctccacgg caccatggcc    420

ccgaagctgc tgctcctcct ctgcctgttc tcgggcttgc acgcgcggtc cagaaaggtg    480

gaagaggatg aatatgaaga ttcatcatca aaccaaaagt gggtcttggc tccaaaatcc    540

caagacaccg acgtgactct tattctcaac aagttgctaa gagaatatga taaaaagctg    600

aggccagata ttggaataaa accgaccgta attgacgttg acatttatgt taacagcatt    660

ggtcctgtgt catcaataaa catggaatac caaattgaca tattttttgc tcagacctgg    720

acagatagtc gccttcgatt caacagcaca atgaaaattc ttactctgaa cagcaacatg    780

gtggggttaa tctggatccc agacaccatc ttccgcaatt ctaaaaccgc agaggctcac    840

tggatcacca cacccaatca gctcctccgg atttggaatg acgggaaaat cctttacact    900

ttgaggctca ccatcaatgc tgagtgccag ctgcagctgc acaacttccc catggacgaa    960

cactcctgcc cgctgatttt ctccagctgt gagtaccagt ccaagcccgg ggtgtgcatg   1020

ctgtgtgagg gatgcctagc ctggtactgc ttctgtcaaa cagtcatgtg a            1071


<210>  5156
<211>  356
<212>  PRT
<213>  Homosapiens

<400>  5156

Met Cys Trp Ala Glu Glu Asp Glu Asn Ala Arg Lys Ser Pro Gly Lys 
1               5                   10                  15      


Ala Gly Ser Trp His Ser Ala His Ser Pro Gly Leu Gly Thr Arg Ala 
            20                  25                  30          


Arg Ser Arg Leu Gln Ala Gly Trp Ala Ala Pro Arg Gln Gly Val Pro 
        35                  40                  45              


Gly Ala His Cys Ser Arg Arg Pro Val Ala Arg Thr Gly Ala Ser Ala 
    50                  55                  60                  


Arg Val Gly Ala Ala Arg Arg Gly Gly Pro Ala Ser Arg Val Arg Pro 
65                  70                  75                  80  


Val Cys Ala Pro Arg Gly Arg Gly Gln Arg Gln Ser Arg Tyr Leu Ser 
                85                  90                  95      


Arg Pro Pro Arg Pro Ala Ala Ser Glu Glu Ala Arg Ala Lys Arg Ala 
            100                 105                 110         


Gly Gly Asp Gln Val Arg Ala Gly Gly Ser Arg Ala Arg Pro Arg Pro 
        115                 120                 125             


Arg Thr Leu Arg Pro Glu Leu His Gly Thr Met Ala Pro Lys Leu Leu 
    130                 135                 140                 


Leu Leu Leu Cys Leu Phe Ser Gly Leu His Ala Arg Ser Arg Lys Val 
145                 150                 155                 160 


Glu Glu Asp Glu Tyr Glu Asp Ser Ser Ser Asn Gln Lys Trp Val Leu 
                165                 170                 175     


Ala Pro Lys Ser Gln Asp Thr Asp Val Thr Leu Ile Leu Asn Lys Leu 
            180                 185                 190         


Leu Arg Glu Tyr Asp Lys Lys Leu Arg Pro Asp Ile Gly Ile Lys Pro 
        195                 200                 205             


Thr Val Ile Asp Val Asp Ile Tyr Val Asn Ser Ile Gly Pro Val Ser 
    210                 215                 220                 


Ser Ile Asn Met Glu Tyr Gln Ile Asp Ile Phe Phe Ala Gln Thr Trp 
225                 230                 235                 240 


Thr Asp Ser Arg Leu Arg Phe Asn Ser Thr Met Lys Ile Leu Thr Leu 
                245                 250                 255     


Asn Ser Asn Met Val Gly Leu Ile Trp Ile Pro Asp Thr Ile Phe Arg 
            260                 265                 270         


Asn Ser Lys Thr Ala Glu Ala His Trp Ile Thr Thr Pro Asn Gln Leu 
        275                 280                 285             


Leu Arg Ile Trp Asn Asp Gly Lys Ile Leu Tyr Thr Leu Arg Leu Thr 
    290                 295                 300                 


Ile Asn Ala Glu Cys Gln Leu Gln Leu His Asn Phe Pro Met Asp Glu 
305                 310                 315                 320 


His Ser Cys Pro Leu Ile Phe Ser Ser Cys Glu Tyr Gln Ser Lys Pro 
                325                 330                 335     


Gly Val Cys Met Leu Cys Glu Gly Cys Leu Ala Trp Tyr Cys Phe Cys 
            340                 345                 350         


Gln Thr Val Met 
        355     


<210>  5157
<211>  273
<212>  DNA
<213>  Homosapiens

<400>  5157
atgcccaaga gaaaggctga aggggatgct aaagaagata aggccaagat aaaggacaaa     60

ctacagggaa gatccacaaa gttgtctgga aagcctgctc tgccaaagcc acagctgaag    120

cctaaaaagg cccctacaaa aaagggagag aaagtatcca aaggggaaaa aggaagagcc    180

aactctgaca aagaggtgaa taaacctgca gaaaatggag atgccagaac ggagaaggca    240

cagaaagctg aaggtgctgg agatgccaag tga                                 273


<210>  5158
<211>  90
<212>  PRT
<213>  Homosapiens

<400>  5158

Met Pro Lys Arg Lys Ala Glu Gly Asp Ala Lys Glu Asp Lys Ala Lys 
1               5                   10                  15      


Ile Lys Asp Lys Leu Gln Gly Arg Ser Thr Lys Leu Ser Gly Lys Pro 
            20                  25                  30          


Ala Leu Pro Lys Pro Gln Leu Lys Pro Lys Lys Ala Pro Thr Lys Lys 
        35                  40                  45              


Gly Glu Lys Val Ser Lys Gly Glu Lys Gly Arg Ala Asn Ser Asp Lys 
    50                  55                  60                  


Glu Val Asn Lys Pro Ala Glu Asn Gly Asp Ala Arg Thr Glu Lys Ala 
65                  70                  75                  80  


Gln Lys Ala Glu Gly Ala Gly Asp Ala Lys 
                85                  90  


<210>  5159
<211>  273
<212>  DNA
<213>  Homosapiens

<400>  5159
atgcccaaga gaaaggctga aggggatgct aaagaagata aggccaagat aaaggacaaa     60

ctacagggaa gatccacaaa gttgtctgga aagcctgctc tgccaaagcc acagctgaag    120

cctaaaaagg cccctacaaa aaagggagag aaagtatcca aaggggaaaa aggaagagcc    180

aactctgaca aagaggtgaa taaacctgca gaaaatggag atgccagaac ggagaaggca    240

cagaaagctg aaggtgctgg agatgccaag tga                                 273


<210>  5160
<211>  90
<212>  PRT
<213>  Homosapiens

<400>  5160

Met Pro Lys Arg Lys Ala Glu Gly Asp Ala Lys Glu Asp Lys Ala Lys 
1               5                   10                  15      


Ile Lys Asp Lys Leu Gln Gly Arg Ser Thr Lys Leu Ser Gly Lys Pro 
            20                  25                  30          


Ala Leu Pro Lys Pro Gln Leu Lys Pro Lys Lys Ala Pro Thr Lys Lys 
        35                  40                  45              


Gly Glu Lys Val Ser Lys Gly Glu Lys Gly Arg Ala Asn Ser Asp Lys 
    50                  55                  60                  


Glu Val Asn Lys Pro Ala Glu Asn Gly Asp Ala Arg Thr Glu Lys Ala 
65                  70                  75                  80  


Gln Lys Ala Glu Gly Ala Gly Asp Ala Lys 
                85                  90  


<210>  5161
<211>  243
<212>  DNA
<213>  Homosapiens

<400>  5161
atggcagagg aacaacaaca gccgccacca cagcagcctg atgcccatca gcagcttccc     60

cccagcgccc ccaactcggg ggtggccctg ccagcccttg tgcccgggct gccagggaca    120

gaggccagcg cgctgcaaca caagatcaag aactccatct ggcaagacct cataagcctc    180

ttcttaaaac ggtcatataa gatctatcgt tttgcccact ttatggaaag agataaacaa    240

tga                                                                  243


<210>  5162
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  5162

Met Ala Glu Glu Gln Gln Gln Pro Pro Pro Gln Gln Pro Asp Ala His 
1               5                   10                  15      


Gln Gln Leu Pro Pro Ser Ala Pro Asn Ser Gly Val Ala Leu Pro Ala 
            20                  25                  30          


Leu Val Pro Gly Leu Pro Gly Thr Glu Ala Ser Ala Leu Gln His Lys 
        35                  40                  45              


Ile Lys Asn Ser Ile Trp Gln Asp Leu Ile Ser Leu Phe Leu Lys Arg 
    50                  55                  60                  


Ser Tyr Lys Ile Tyr Arg Phe Ala His Phe Met Glu Arg Asp Lys Gln 
65                  70                  75                  80  


<210>  5163
<211>  138
<212>  DNA
<213>  Homosapiens

<400>  5163
atggagggga acagggatga agctgagaaa tgtgtcgaca tcgtccagga ggctctgaat     60

gctggcaacc gcgagaaggc ccagcgtttc ctgcagaagg ccgagaagct ctacccactg    120

cccttggcct gcgcataa                                                  138


<210>  5164
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  5164

Met Glu Gly Asn Arg Asp Glu Ala Glu Lys Cys Val Asp Ile Val Gln 
1               5                   10                  15      


Glu Ala Leu Asn Ala Gly Asn Arg Glu Lys Ala Gln Arg Phe Leu Gln 
            20                  25                  30          


Lys Ala Glu Lys Leu Tyr Pro Leu Pro Leu Ala Cys Ala 
        35                  40                  45  


<210>  5165
<211>  723
<212>  DNA
<213>  Homosapiens

<400>  5165
atggtggtaa ccaggaacag ttcccttccc ccaccacaca cccccccaaa aagactagaa     60

aaaaaactgg tcaacttgga cgctggccgc gctcacgcag aacccgtgcc cgcgggccgg    120

ggaaggctga acagaccctg ggaggaaaag tgggcctgca ggcaccccgg gctccccccg    180

ccgcctgtct cagataccga gcaggtggga ttccgggaag ccacctccga cttacgagcc    240

ccccacgcgt ccgacgcaga ggcgcgggtg ctactctcag caccgccgcg ccatcccggg    300

gcggaccgag ccgcggagca cctcccggat ctcaggagct ctcgggcgga gatctcggcc    360

atccgtgcct cctccccgaa cccacccgcc ccgctcccgc gcccccggct gtcacctctc    420

cgggccgtga cagctccacc tgccaccgct gcccgggtcg ccgcccccgc actcaccacc    480

cagctggctc ccgtgcgagc agcggatcga gctcggagag cggcgccgga atcccgcacg    540

cgcggtagcg gaacacgagg ggctgaatgc cgcggcgctc tgagcccgct tagctcatcc    600

ccagcccggc gctccgccct tcgcggcacc cccgcccgcc cgcccaggcc tgccgtctca    660

gtcagacggg actccccctc ccctcgcggc cgccactgcc tccgcctctt tctccgactc    720

tag                                                                  723


<210>  5166
<211>  240
<212>  PRT
<213>  Homosapiens

<400>  5166

Met Val Val Thr Arg Asn Ser Ser Leu Pro Pro Pro His Thr Pro Pro 
1               5                   10                  15      


Lys Arg Leu Glu Lys Lys Leu Val Asn Leu Asp Ala Gly Arg Ala His 
            20                  25                  30          


Ala Glu Pro Val Pro Ala Gly Arg Gly Arg Leu Asn Arg Pro Trp Glu 
        35                  40                  45              


Glu Lys Trp Ala Cys Arg His Pro Gly Leu Pro Pro Pro Pro Val Ser 
    50                  55                  60                  


Asp Thr Glu Gln Val Gly Phe Arg Glu Ala Thr Ser Asp Leu Arg Ala 
65                  70                  75                  80  


Pro His Ala Ser Asp Ala Glu Ala Arg Val Leu Leu Ser Ala Pro Pro 
                85                  90                  95      


Arg His Pro Gly Ala Asp Arg Ala Ala Glu His Leu Pro Asp Leu Arg 
            100                 105                 110         


Ser Ser Arg Ala Glu Ile Ser Ala Ile Arg Ala Ser Ser Pro Asn Pro 
        115                 120                 125             


Pro Ala Pro Leu Pro Arg Pro Arg Leu Ser Pro Leu Arg Ala Val Thr 
    130                 135                 140                 


Ala Pro Pro Ala Thr Ala Ala Arg Val Ala Ala Pro Ala Leu Thr Thr 
145                 150                 155                 160 


Gln Leu Ala Pro Val Arg Ala Ala Asp Arg Ala Arg Arg Ala Ala Pro 
                165                 170                 175     


Glu Ser Arg Thr Arg Gly Ser Gly Thr Arg Gly Ala Glu Cys Arg Gly 
            180                 185                 190         


Ala Leu Ser Pro Leu Ser Ser Ser Pro Ala Arg Arg Ser Ala Leu Arg 
        195                 200                 205             


Gly Thr Pro Ala Arg Pro Pro Arg Pro Ala Val Ser Val Arg Arg Asp 
    210                 215                 220                 


Ser Pro Ser Pro Arg Gly Arg His Cys Leu Arg Leu Phe Leu Arg Leu 
225                 230                 235                 240 


<210>  5167
<211>  3281
<212>  DNA
<213>  Homosapiens

<400>  5167
cagcgttcac ctctcagcca agtccaatag cactcactta ggtgtgcatc tgtggctttc     60

tctctgtctg gtcagtgctc ctttatatgt ccataccccc tgccagaggg cagcattgag    120

ggtgtacaga gcccagtgtg actctcctgc agctggggac atagaagagc tctgtgacga    180

tggcagatgt ggttctccag cctcttgcct ggctgccagt gggagtagcc tgtctgttct    240

ggcacagggg gctgttccat atggagggtc agaaactggc cttcacagcc acccaggcgt    300

tccttccact tctgcacgtc ttcctttccc catgaagatt tgggtgtacc ctggttgtgg    360

tctctgaaga ctgggcaggc ctgtactttg tgaagctttc agctgtctct ggtaggcctg    420

atgaagccta tctgcagagg ttggcctgaa gccataatga gcagttctgt tctttttagc    480

ccttgtctag tttatggctc tgttgcagac atgcctttct gtgtcttggt taaaagtact    540

ggtgtgtctt tgcatttagg tgtggtctgt gagtctggga aagcttctag aggagagccc    600

tccagggttg ctctttgggg tgggagtagt gggagcggaa atggaacgct gactgccctc    660

ttaaagccag aagggtactt cattcagggc aggcagttgg catgtgtagg cactcaggag    720

tcttccttca gtttcagcgg ccggtgttca tcatcaggag tggcagggtt ggatatggga    780

gtgagaatgt gcctctgaga ttgaccagtg gccatagact ccagcaagat gtgcatcttg    840

gtctgagagg cacccactgt accagaaacc agacttgtat cgaccaatgg cttatcagcc    900

ccaggaggct tattactgcc acaaatgtcc ctgatggtga gcagcacttg gccactactg    960

tctgatgtta accagagtta tgggggtggt ttctgcaaat acacaatact gtggaggggt   1020

tatgtggctt acccagaggt gcccagatag caaatgaagg tgtaagattg gaatccctgt   1080

ctttctggtt gacccttggc ttggctaatc attcattcat tcattccaca cacattgatg   1140

aatgccgact ctgtactggg ttctgttcta ggaactagac agacacatca cctatgctgc   1200

tcttgtgggg cttctgttcc gctgggggag acagtcagta gtaagccttc aagcaaaggc   1260

atggctgctg gtgtgatgag tgccatgaag acccataagg ctgcgttaaa ggagatgggt   1320

ggtccaggaa ggcctctctg aggaggtggc atttgagcac tcaagtgcct tacactggac   1380

ttctgacccc atgagctgga acttaggata tctgatctag aagtacctct agaagtcctc   1440

ttcccaataa acaagctaag gcccagtgag cttaaggtgt gaattcatgg ggtgattcat   1500

gggaaagatg aaattaaacc caagaaggac aagtataata gccggccact gctctgctca   1560

caccagcctt gggctccagc cctctgcctt ttcatcccag aatgtgtttt attatcttca   1620

agactcagcc ctttgaaaga tttagactgc caaattgcat ttattaacaa taataaatct   1680

attttctcat ggctgggtgt ggggaggggg tagaaatttt aaacacattt gtgacggttg   1740

atcagccctc caggtaaggc aacggctgac tgcctggagc tggtgttttt cctgcctagg   1800

cggagacacc gcccaatttt gtaccaccag ctgctgtcac tgtcagagtg gaatttccat   1860

tggtgtttct gaaatagcag tgtttcctgg aggaccccca tttgtacttt ctggattcca   1920

tctggacctg gtttaggggg ttagatgctt ttgaatgggg gctggagaga ccctactgat   1980

gcctctgacc agagatggtg aggcaggact cacagggccc ccagggttta ttttagggag   2040

agagaagccc acagttaaat cagaggtcac aaatacagca gcagacccca cctctcccaa   2100

ggaccagact gagctataat tggccaataa tttcatctaa aagcaggaat cctacatcaa   2160

tttgaaagga gcttctggct gaagtaagac tttattaatt agcctgttag gaaaatagtt   2220

tcccagtatt atgagggctg gataatttca tgcccactgt ttttcttgaa gcttctcaaa   2280

ggcagacaca gccgcgtgca gcggctcacg cctacaatct cagcacgttg ggaggtcgag   2340

gcaggtggat cacgaggcca ggagatcgag accatcctgg ccaacatggt gaaaccccat   2400

ctctacaaaa atacaaaaat taattgggcg tggtggtggg cgcctgtaat cccagctact   2460

caggaggctg aggcaggaga atcagaggtt gcagtgaacc gagattgtgc cactacactc   2520

cagcctggcc acagagcgag actcagaaaa caagggaaga cactagattt tcatttttgt   2580

actaaataga aaaagtaata tctttttaaa aatgtgtttt gtttgttttt aactgtttgt   2640

tcatgccaat gtgccaggca ccatatttat tctttaatct atacagaaat gctgctggat   2700

gaatggaatt atgctcactc tgccaatgag ggaaccaagg ctcagaaagg ttaagtaacc   2760

aacctaaggt caggtagtac tgaggagctg tgcttggata caaaaccagg tcatccaacc   2820

tggaatctta gctttgaccc ccaaccttct cccggcaact ttgatgataa tatggaaata   2880

ccttagactc ttgacttgac tttactttct cttctctgtt ataaaatctg ctacattcct   2940

tttcctggga aagcgaaata gattatgcca aaagttctga tttttaaaaa tgttttattg   3000

tgggccgggc gcagtggctc atgcctgtaa tcccaggact ttgggaggcc gaggtgggtg   3060

gatcatgaag tcaggagatc aagaccatcc tggccaacac agtgaaaccc catgtctact   3120

aaaaatacaa aaattaactg ggcttggtgg tgcacgcctg taatcccagc tactcaggag   3180

gctgaggcgg gagaatccct tgaacctggg aggcggaggt tgtagtgagc cgagattgtg   3240

ccactgcact ccagcctggc aacagagcaa ggctccgtct c                       3281


<210>  5168
<211>  125
<212>  PRT
<213>  Homosapiens

<400>  5168

Met Lys Pro Ile Cys Arg Gly Trp Pro Glu Ala Ile Met Ser Ser Ser 
1               5                   10                  15      


Val Leu Phe Ser Pro Cys Leu Val Tyr Gly Ser Val Ala Asp Met Pro 
            20                  25                  30          


Phe Cys Val Leu Val Lys Ser Thr Gly Val Ser Leu His Leu Gly Val 
        35                  40                  45              


Val Cys Glu Ser Gly Lys Ala Ser Arg Gly Glu Pro Ser Arg Val Ala 
    50                  55                  60                  


Leu Trp Gly Gly Ser Ser Gly Ser Gly Asn Gly Thr Leu Thr Ala Leu 
65                  70                  75                  80  


Leu Lys Pro Glu Gly Tyr Phe Ile Gln Gly Arg Gln Leu Ala Cys Val 
                85                  90                  95      


Gly Thr Gln Glu Ser Ser Phe Ser Phe Ser Gly Arg Cys Ser Ser Ser 
            100                 105                 110         


Gly Val Ala Gly Leu Asp Met Gly Val Arg Met Cys Leu 
        115                 120                 125 


<210>  5169
<211>  930
<212>  DNA
<213>  Homosapiens

<400>  5169
atgaggggaa aatatagatc cggggacgcg cggccggctc gcgcgcgggc tcgcggactt     60

gccggggagg gccccggggg tcccgccttg gccgtccacc gggcggtgcg cgctttgagg    120

tccactccct gcttgctcgt ctgccccgcc gtaaccccga gcgcgggagg gcgaggccat    180

cggtttgcgg gcaagctggc cccggagtcg agtggcctgt gcgaccaagc ggggggtccg    240

gggggcccgg ggccggggcg agcgagcggg ggagcgtccg cgtccctcgg agtgtccagg    300

ctagcgaccg agacacctac aggcttccgc caacgccgtg gcactgccgg gagcaggctg    360

agcaaaccag tccctatttg gaactgctct cgcggcagtt cagacctcgt gctcgtcccc    420

ttcgcctgtc tgtgtgtggt atcccgctct cctgcctgtg cgctccgacg cggcagcggc    480

ggtggcgctg agcgctcctc ggtggggacg cggtgctcaa gctgggagca gcgagaaccc    540

tttgcggagg cttcccggct tgcagcggcg gcggcggcgg cggcagcggc agtagcagac    600

ggaacagcag gctctcctct ccgagggggg gcgtcgaagc gcccgcgccg ggctcccgcc    660

ctcaccctcc ggcgctcctg cggccccaag ccaccacctc gtagcccgcc tccttcctct    720

tctcgccgcg agccccaggc ccggacgcct ctaggatcgg acccgcgcgc cccggatgct    780

tggggctgcc ccggcgcgcc cccctacagg cgcgacccgc tgagtgaccc ggagggggcc    840

cgagctcgcc ccaggagggg cccccggcct cgggaccccg cgccggacct gctggggagc    900

cgacgatgtc cgcgcagtcc caggcattga                                     930


<210>  5170
<211>  309
<212>  PRT
<213>  Homosapiens

<400>  5170

Met Arg Gly Lys Tyr Arg Ser Gly Asp Ala Arg Pro Ala Arg Ala Arg 
1               5                   10                  15      


Ala Arg Gly Leu Ala Gly Glu Gly Pro Gly Gly Pro Ala Leu Ala Val 
            20                  25                  30          


His Arg Ala Val Arg Ala Leu Arg Ser Thr Pro Cys Leu Leu Val Cys 
        35                  40                  45              


Pro Ala Val Thr Pro Ser Ala Gly Gly Arg Gly His Arg Phe Ala Gly 
    50                  55                  60                  


Lys Leu Ala Pro Glu Ser Ser Gly Leu Cys Asp Gln Ala Gly Gly Pro 
65                  70                  75                  80  


Gly Gly Pro Gly Pro Gly Arg Ala Ser Gly Gly Ala Ser Ala Ser Leu 
                85                  90                  95      


Gly Val Ser Arg Leu Ala Thr Glu Thr Pro Thr Gly Phe Arg Gln Arg 
            100                 105                 110         


Arg Gly Thr Ala Gly Ser Arg Leu Ser Lys Pro Val Pro Ile Trp Asn 
        115                 120                 125             


Cys Ser Arg Gly Ser Ser Asp Leu Val Leu Val Pro Phe Ala Cys Leu 
    130                 135                 140                 


Cys Val Val Ser Arg Ser Pro Ala Cys Ala Leu Arg Arg Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ala Glu Arg Ser Ser Val Gly Thr Arg Cys Ser Ser Trp Glu 
                165                 170                 175     


Gln Arg Glu Pro Phe Ala Glu Ala Ser Arg Leu Ala Ala Ala Ala Ala 
            180                 185                 190         


Ala Ala Ala Ala Ala Val Ala Asp Gly Thr Ala Gly Ser Pro Leu Arg 
        195                 200                 205             


Gly Gly Ala Ser Lys Arg Pro Arg Arg Ala Pro Ala Leu Thr Leu Arg 
    210                 215                 220                 


Arg Ser Cys Gly Pro Lys Pro Pro Pro Arg Ser Pro Pro Pro Ser Ser 
225                 230                 235                 240 


Ser Arg Arg Glu Pro Gln Ala Arg Thr Pro Leu Gly Ser Asp Pro Arg 
                245                 250                 255     


Ala Pro Asp Ala Trp Gly Cys Pro Gly Ala Pro Pro Tyr Arg Arg Asp 
            260                 265                 270         


Pro Leu Ser Asp Pro Glu Gly Ala Arg Ala Arg Pro Arg Arg Gly Pro 
        275                 280                 285             


Arg Pro Arg Asp Pro Ala Pro Asp Leu Leu Gly Ser Arg Arg Cys Pro 
    290                 295                 300                 


Arg Ser Pro Arg His 
305                 


<210>  5171
<211>  930
<212>  DNA
<213>  Homosapiens

<400>  5171
atgaggggaa aatatagatc cggggacgcg cggccggctc gcgcgcgggc tcgcggactt     60

gccggggagg gccccggggg tcccgccttg gccgtccacc gggcggtgcg cgctttgagg    120

tccactccct gcttgctcgt ctgccccgcc gtaaccccga gcgcgggagg gcgaggccat    180

cggtttgcgg gcaagctggc cccggagtcg agtggcctgt gcgaccaagc ggggggtccg    240

gggggcccgg ggccggggcg agcgagcggg ggagcgtccg cgtccctcgg agtgtccagg    300

ctagcgaccg agacacctac aggcttccgc caacgccgtg gcactgccgg gagcaggctg    360

agcaaaccag tccctatttg gaactgctct cgcggcagtt cagacctcgt gctcgtcccc    420

ttcgcctgtc tgtgtgtggt atcccgctct cctgcctgtg cgctccgacg cggcagcggc    480

ggtggcgctg agcgctcctc ggtggggacg cggtgctcaa gctgggagca gcgagaaccc    540

tttgcggagg cttcccggct tgcagcggcg gcggcggcgg cggcagcggc agtagcagac    600

ggaacagcag gctctcctct ccgagggggg gcgtcgaagc gcccgcgccg ggctcccgcc    660

ctcaccctcc ggcgctcctg cggccccaag ccaccacctc gtagcccgcc tccttcctct    720

tctcgccgcg agccccaggc ccggacgcct ctaggatcgg acccgcgcgc cccggatgct    780

tggggctgcc ccggcgcgcc cccctacagg cgcgacccgc tgagtgaccc ggagggggcc    840

cgagctcgcc ccaggagggg cccccggcct cgggaccccg cgccggacct gctggggagc    900

cgacgatgtc cgcgcagtcc caggcattga                                     930


<210>  5172
<211>  309
<212>  PRT
<213>  Homosapiens

<400>  5172

Met Arg Gly Lys Tyr Arg Ser Gly Asp Ala Arg Pro Ala Arg Ala Arg 
1               5                   10                  15      


Ala Arg Gly Leu Ala Gly Glu Gly Pro Gly Gly Pro Ala Leu Ala Val 
            20                  25                  30          


His Arg Ala Val Arg Ala Leu Arg Ser Thr Pro Cys Leu Leu Val Cys 
        35                  40                  45              


Pro Ala Val Thr Pro Ser Ala Gly Gly Arg Gly His Arg Phe Ala Gly 
    50                  55                  60                  


Lys Leu Ala Pro Glu Ser Ser Gly Leu Cys Asp Gln Ala Gly Gly Pro 
65                  70                  75                  80  


Gly Gly Pro Gly Pro Gly Arg Ala Ser Gly Gly Ala Ser Ala Ser Leu 
                85                  90                  95      


Gly Val Ser Arg Leu Ala Thr Glu Thr Pro Thr Gly Phe Arg Gln Arg 
            100                 105                 110         


Arg Gly Thr Ala Gly Ser Arg Leu Ser Lys Pro Val Pro Ile Trp Asn 
        115                 120                 125             


Cys Ser Arg Gly Ser Ser Asp Leu Val Leu Val Pro Phe Ala Cys Leu 
    130                 135                 140                 


Cys Val Val Ser Arg Ser Pro Ala Cys Ala Leu Arg Arg Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ala Glu Arg Ser Ser Val Gly Thr Arg Cys Ser Ser Trp Glu 
                165                 170                 175     


Gln Arg Glu Pro Phe Ala Glu Ala Ser Arg Leu Ala Ala Ala Ala Ala 
            180                 185                 190         


Ala Ala Ala Ala Ala Val Ala Asp Gly Thr Ala Gly Ser Pro Leu Arg 
        195                 200                 205             


Gly Gly Ala Ser Lys Arg Pro Arg Arg Ala Pro Ala Leu Thr Leu Arg 
    210                 215                 220                 


Arg Ser Cys Gly Pro Lys Pro Pro Pro Arg Ser Pro Pro Pro Ser Ser 
225                 230                 235                 240 


Ser Arg Arg Glu Pro Gln Ala Arg Thr Pro Leu Gly Ser Asp Pro Arg 
                245                 250                 255     


Ala Pro Asp Ala Trp Gly Cys Pro Gly Ala Pro Pro Tyr Arg Arg Asp 
            260                 265                 270         


Pro Leu Ser Asp Pro Glu Gly Ala Arg Ala Arg Pro Arg Arg Gly Pro 
        275                 280                 285             


Arg Pro Arg Asp Pro Ala Pro Asp Leu Leu Gly Ser Arg Arg Cys Pro 
    290                 295                 300                 


Arg Ser Pro Arg His 
305                 


<210>  5173
<211>  441
<212>  DNA
<213>  Homosapiens

<400>  5173
atgcgggtgg gggaaaactg gggttgccaa agccgcctct ccgccttcag tccgcccctc     60

cagtccgccg ctcccggcgc ccctgccgcc gcgcccgccc agcgacccca tgacacagat    120

cggcttaaag ctccccgcct gtccgcctgc cctcgagaga gggtcccgac ccccagacag    180

gtctccgaag gctgggcttc gcctcacgcc gacctccggc cccaccccac ccgcgtaact    240

ataaactcca gctacttgcc gcgctgcttt tgcacagact catgccctgc cccagaaggg    300

acagtggccg tgctgtggcg ggaacagcgg gcgggctggt ccagagcagg gcctgcctgg    360

gtgaggagga tttggagggc caggccctgt cgtcacaggg ttatgaggcc gaagggacca    420

ttccatttac aactgcgctg a                                              441


<210>  5174
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  5174

Met Arg Val Gly Glu Asn Trp Gly Cys Gln Ser Arg Leu Ser Ala Phe 
1               5                   10                  15      


Ser Pro Pro Leu Gln Ser Ala Ala Pro Gly Ala Pro Ala Ala Ala Pro 
            20                  25                  30          


Ala Gln Arg Pro His Asp Thr Asp Arg Leu Lys Ala Pro Arg Leu Ser 
        35                  40                  45              


Ala Cys Pro Arg Glu Arg Val Pro Thr Pro Arg Gln Val Ser Glu Gly 
    50                  55                  60                  


Trp Ala Ser Pro His Ala Asp Leu Arg Pro His Pro Thr Arg Val Thr 
65                  70                  75                  80  


Ile Asn Ser Ser Tyr Leu Pro Arg Cys Phe Cys Thr Asp Ser Cys Pro 
                85                  90                  95      


Ala Pro Glu Gly Thr Val Ala Val Leu Trp Arg Glu Gln Arg Ala Gly 
            100                 105                 110         


Trp Ser Arg Ala Gly Pro Ala Trp Val Arg Arg Ile Trp Arg Ala Arg 
        115                 120                 125             


Pro Cys Arg His Arg Val Met Arg Pro Lys Gly Pro Phe His Leu Gln 
    130                 135                 140                 


Leu Arg 
145     


<210>  5175
<211>  441
<212>  DNA
<213>  Homosapiens

<400>  5175
atgcgggtgg gggaaaactg gggttgccaa agccgcctct ccgccttcag tccgcccctc     60

cagtccgccg ctcccggcgc ccctgccgcc gcgcccgccc agcgacccca tgacacagat    120

cggcttaaag ctccccgcct gtccgcctgc cctcgagaga gggtcccgac ccccagacag    180

gtctccgaag gctgggcttc gcctcacgcc gacctccggc cccaccccac ccgcgtaact    240

ataaactcca gctacttgcc gcgctgcttt tgcacagact catgccctgc cccagaaggg    300

acagtggccg tgctgtggcg ggaacagcgg gcgggctggt ccagagcagg gcctgcctgg    360

gtgaggagga tttggagggc caggccctgt cgtcacaggg ttatgaggcc gaagggacca    420

ttccatttac aactgcgctg a                                              441


<210>  5176
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  5176

Met Arg Val Gly Glu Asn Trp Gly Cys Gln Ser Arg Leu Ser Ala Phe 
1               5                   10                  15      


Ser Pro Pro Leu Gln Ser Ala Ala Pro Gly Ala Pro Ala Ala Ala Pro 
            20                  25                  30          


Ala Gln Arg Pro His Asp Thr Asp Arg Leu Lys Ala Pro Arg Leu Ser 
        35                  40                  45              


Ala Cys Pro Arg Glu Arg Val Pro Thr Pro Arg Gln Val Ser Glu Gly 
    50                  55                  60                  


Trp Ala Ser Pro His Ala Asp Leu Arg Pro His Pro Thr Arg Val Thr 
65                  70                  75                  80  


Ile Asn Ser Ser Tyr Leu Pro Arg Cys Phe Cys Thr Asp Ser Cys Pro 
                85                  90                  95      


Ala Pro Glu Gly Thr Val Ala Val Leu Trp Arg Glu Gln Arg Ala Gly 
            100                 105                 110         


Trp Ser Arg Ala Gly Pro Ala Trp Val Arg Arg Ile Trp Arg Ala Arg 
        115                 120                 125             


Pro Cys Arg His Arg Val Met Arg Pro Lys Gly Pro Phe His Leu Gln 
    130                 135                 140                 


Leu Arg 
145     


<210>  5177
<211>  2221
<212>  DNA
<213>  Homosapiens

<400>  5177
attcgccatg gccgcctcgc cgggctcggg cagcgccaac ccgcggaagt tcagtgagaa     60

gatcgcgctg cacacgcaga gacaggccga ggagacgcgg gccttcgagc agctcatgac    120

cgacctcacc ctgtcgcggg ttcaatttca gaagcttcag caactgcgcc ttacacagta    180

ccatggagga tccttaccaa atgtgagcca gctgcggagc aatgcgtcag agtttcagcc    240

gtcatttcac caagctgata atgttcgggg aacccgccat cacgggctgg tggagaggcc    300

atccaggaac cgcttccacc ccctccaccg aaggtctggg gacaagccag ggcgacaatt    360

tgatggtagt gcttttggag ccaattattc ctcacagcct ctggatgaga gttggccaag    420

gcagcagcct ccttggaaag acgaaaagca tcctgggttc aggctgacat ctgcacttaa    480

caggaccaat tctgattctg ctcttcacac gagtgctctg agtaccaagc cccaggaccc    540

ctatggagga gggggccagt cggcctggcc tgccccatac atggggtttt gtgatggtga    600

gaataatgga catggggaag tagcatcttt ccctggccca ttgaaagaag agaatctgtt    660

aaatgttcct aagccactgc caaaacaact gtgggagacc aaggagattc agtccctgtc    720

aggacgccct cgatcctgtg atgttggagg tggcaatgct tttccacata atggtcaaaa    780

cctaggcctc tcacccttct tggggacttt gaacactgga gggtcattgc cagatctaac    840

caacctccac tactcgacac ccctgccagc ctccctggac accaccgacc accactttgg    900

cagtatgagt gtggggaata gtgtgaacaa catcccagct gctatgaccc acctgggtat    960

aagaagctcc tctggtctcc agagttctcg gagtaacccc tccatccaag ccacgctcaa   1020

taagactgtg ctttcctctt ccttaaataa ccacccacag acatctgttc ccaacgcatc   1080

tgctcttcac ccttcgctcc gtctgttttc ccttagcaac ccatctcttt ccaccacaaa   1140

cctgagcggc ccgtctcgcc gtcggcagcc tcccgtcagc cctctcacgc tttctcctgg   1200

ccctgaagca catcaaggtt tcagcagaca gctgtcttca accagcccac tggccccata   1260

tcctacctcc cagatggtgt cctcagaccg aagccaactt tcctttctgc ccacagaagc   1320

tcaagcccag gtgtcgccgc caccccctta ccctgcaccc caggagctca cccagcccct   1380

cctgcagcag ccccgcgccc ctgaggcccc tgcccagcag ccccaggcag cctcctcact   1440

gccacagtca gactttcagc ttctcccggc ccagggctca tctttgacca acttcttccc   1500

agatgtgggt tttgaccagc agtccatgag gccaggccct gcctttcctc aacaggtgcc   1560

tctggtgcaa caaggttccc gagaactgca ggactctttt catttgagac caagcccgta   1620

ttccaactgc gggagtctcc cgaacaccat cctgccagaa gactccagca ccagcctgtt   1680

caaagacctc aacagtgcgc tggcaggcct gcctgaggtc agcctgaacg tggacactcc   1740

atttccactg gaagaggagc tgcagattga acccctgagc ctggatggac tcaacatgtt   1800

aagtgactcc agcatgggcc tgctggaccc ctctgttgaa gagacgtttc gagctgacag   1860

actgtgaaca gaaggcagtg gaacagaaga atgtttttct gcaacagcca aaatagaatg   1920

gaatagaatg aagccagctg ataccacggg ctttcgttat cttgacatag aaggaagcag   1980

tgccacggct ccagggtttc agatgagatc ccatctcaga cactgtggct tcctccagat   2040

cacacagctt tgtactgcct ctcccgcctg tggccaaagt cgtgttgcag caggcaggct   2100

gcttggagct tcccatgaac tggaaagctc acctccactg catcttttta ctggccatcc   2160

agtcagccga tgtgtaagag taggaaatac tgtgtcactg gaggccctcc gtagcattgg   2220

g                                                                   2221


<210>  5178
<211>  619
<212>  PRT
<213>  Homosapiens

<400>  5178

Met Ala Ala Ser Pro Gly Ser Gly Ser Ala Asn Pro Arg Lys Phe Ser 
1               5                   10                  15      


Glu Lys Ile Ala Leu His Thr Gln Arg Gln Ala Glu Glu Thr Arg Ala 
            20                  25                  30          


Phe Glu Gln Leu Met Thr Asp Leu Thr Leu Ser Arg Val Gln Phe Gln 
        35                  40                  45              


Lys Leu Gln Gln Leu Arg Leu Thr Gln Tyr His Gly Gly Ser Leu Pro 
    50                  55                  60                  


Asn Val Ser Gln Leu Arg Ser Asn Ala Ser Glu Phe Gln Pro Ser Phe 
65                  70                  75                  80  


His Gln Ala Asp Asn Val Arg Gly Thr Arg His His Gly Leu Val Glu 
                85                  90                  95      


Arg Pro Ser Arg Asn Arg Phe His Pro Leu His Arg Arg Ser Gly Asp 
            100                 105                 110         


Lys Pro Gly Arg Gln Phe Asp Gly Ser Ala Phe Gly Ala Asn Tyr Ser 
        115                 120                 125             


Ser Gln Pro Leu Asp Glu Ser Trp Pro Arg Gln Gln Pro Pro Trp Lys 
    130                 135                 140                 


Asp Glu Lys His Pro Gly Phe Arg Leu Thr Ser Ala Leu Asn Arg Thr 
145                 150                 155                 160 


Asn Ser Asp Ser Ala Leu His Thr Ser Ala Leu Ser Thr Lys Pro Gln 
                165                 170                 175     


Asp Pro Tyr Gly Gly Gly Gly Gln Ser Ala Trp Pro Ala Pro Tyr Met 
            180                 185                 190         


Gly Phe Cys Asp Gly Glu Asn Asn Gly His Gly Glu Val Ala Ser Phe 
        195                 200                 205             


Pro Gly Pro Leu Lys Glu Glu Asn Leu Leu Asn Val Pro Lys Pro Leu 
    210                 215                 220                 


Pro Lys Gln Leu Trp Glu Thr Lys Glu Ile Gln Ser Leu Ser Gly Arg 
225                 230                 235                 240 


Pro Arg Ser Cys Asp Val Gly Gly Gly Asn Ala Phe Pro His Asn Gly 
                245                 250                 255     


Gln Asn Leu Gly Leu Ser Pro Phe Leu Gly Thr Leu Asn Thr Gly Gly 
            260                 265                 270         


Ser Leu Pro Asp Leu Thr Asn Leu His Tyr Ser Thr Pro Leu Pro Ala 
        275                 280                 285             


Ser Leu Asp Thr Thr Asp His His Phe Gly Ser Met Ser Val Gly Asn 
    290                 295                 300                 


Ser Val Asn Asn Ile Pro Ala Ala Met Thr His Leu Gly Ile Arg Ser 
305                 310                 315                 320 


Ser Ser Gly Leu Gln Ser Ser Arg Ser Asn Pro Ser Ile Gln Ala Thr 
                325                 330                 335     


Leu Asn Lys Thr Val Leu Ser Ser Ser Leu Asn Asn His Pro Gln Thr 
            340                 345                 350         


Ser Val Pro Asn Ala Ser Ala Leu His Pro Ser Leu Arg Leu Phe Ser 
        355                 360                 365             


Leu Ser Asn Pro Ser Leu Ser Thr Thr Asn Leu Ser Gly Pro Ser Arg 
    370                 375                 380                 


Arg Arg Gln Pro Pro Val Ser Pro Leu Thr Leu Ser Pro Gly Pro Glu 
385                 390                 395                 400 


Ala His Gln Gly Phe Ser Arg Gln Leu Ser Ser Thr Ser Pro Leu Ala 
                405                 410                 415     


Pro Tyr Pro Thr Ser Gln Met Val Ser Ser Asp Arg Ser Gln Leu Ser 
            420                 425                 430         


Phe Leu Pro Thr Glu Ala Gln Ala Gln Val Ser Pro Pro Pro Pro Tyr 
        435                 440                 445             


Pro Ala Pro Gln Glu Leu Thr Gln Pro Leu Leu Gln Gln Pro Arg Ala 
    450                 455                 460                 


Pro Glu Ala Pro Ala Gln Gln Pro Gln Ala Ala Ser Ser Leu Pro Gln 
465                 470                 475                 480 


Ser Asp Phe Gln Leu Leu Pro Ala Gln Gly Ser Ser Leu Thr Asn Phe 
                485                 490                 495     


Phe Pro Asp Val Gly Phe Asp Gln Gln Ser Met Arg Pro Gly Pro Ala 
            500                 505                 510         


Phe Pro Gln Gln Val Pro Leu Val Gln Gln Gly Ser Arg Glu Leu Gln 
        515                 520                 525             


Asp Ser Phe His Leu Arg Pro Ser Pro Tyr Ser Asn Cys Gly Ser Leu 
    530                 535                 540                 


Pro Asn Thr Ile Leu Pro Glu Asp Ser Ser Thr Ser Leu Phe Lys Asp 
545                 550                 555                 560 


Leu Asn Ser Ala Leu Ala Gly Leu Pro Glu Val Ser Leu Asn Val Asp 
                565                 570                 575     


Thr Pro Phe Pro Leu Glu Glu Glu Leu Gln Ile Glu Pro Leu Ser Leu 
            580                 585                 590         


Asp Gly Leu Asn Met Leu Ser Asp Ser Ser Met Gly Leu Leu Asp Pro 
        595                 600                 605             


Ser Val Glu Glu Thr Phe Arg Ala Asp Arg Leu 
    610                 615                 


<210>  5179
<211>  901
<212>  DNA
<213>  Homosapiens

<400>  5179
cagaggcccg ggaatctgca aatgagcgca ttccccaggc agttcccatg caggtgatcc     60

acggaccaca tgttgagaaa ctgcagtcac ccttagggcc acaccgtccc tctcctcgct    120

gtcccctctc tgtagtgact ggccctgacc ttcaggagtg cactttccac tctaccagga    180

agccctatga catcctcagg ctccccagac ctgcagcttg catggggccc ctcccttctt    240

ccacacccac cctccgtatg gtcccctgct ctgccctcgt gctttgctgg cccctgcccg    300

ctactcccac tctcagacac ccaggggtgg tgggccctaa ctggctggcc cctcccagcg    360

ctgccctctg ccgtccagat gctgcagtgt ggccagattt accttccagt aacatacttc    420

tagtcacccc tcctcctgcg aagtgatctg cagtggctgt ttgaccagac cacaaagttc    480

acatctcctg agcttagtgt ccgtggctgt ccacctccca gccatacttg actgtcccca    540

aactctccct gcagccacat gtttcccatg acctgtgggc tctgcagatg gacctctctc    600

cgctagagat gcccttctcc caaatggctt ccctcctgga aggcccagcc tgagtcctcg    660

tctcctttcc agtgcttctg ccagaagcat ccccatgatg ttgtgaccgc acagcacttt    720

gtgtctcgct ttgagcactt gccactctgg ctggtgctgc tgccactgat tgtgtactgt    780

cttgctgccc tttctagact gtgagctcct cgtgggcagg gaccgcctgt gttctctgta    840

tttcccacgg cgcctagcac agtgccttgc acttgatagg tgcttaataa atgtctgctc    900

a                                                                    901


<210>  5180
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  5180

Met Gln Val Ile His Gly Pro His Val Glu Lys Leu Gln Ser Pro Leu 
1               5                   10                  15      


Gly Pro His Arg Pro Ser Pro Arg Cys Pro Leu Ser Val Val Thr Gly 
            20                  25                  30          


Pro Asp Leu Gln Glu Cys Thr Phe His Ser Thr Arg Lys Pro Tyr Asp 
        35                  40                  45              


Ile Leu Arg Leu Pro Arg Pro Ala Ala Cys Met Gly Pro Leu Pro Ser 
    50                  55                  60                  


Ser Thr Pro Thr Leu Arg Met Val Pro Cys Ser Ala Leu Val Leu Cys 
65                  70                  75                  80  


Trp Pro Leu Pro Ala Thr Pro Thr Leu Arg His Pro Gly Val Val Gly 
                85                  90                  95      


Pro Asn Trp Leu Ala Pro Pro Ser Ala Ala Leu Cys Arg Pro Asp Ala 
            100                 105                 110         


Ala Val Trp Pro Asp Leu Pro Ser Ser Asn Ile Leu Leu Val Thr Pro 
        115                 120                 125             


Pro Pro Ala Lys 
    130         


<210>  5181
<211>  901
<212>  DNA
<213>  Homosapiens

<400>  5181
cagaggcccg ggaatctgca aatgagcgca ttccccaggc agttcccatg caggtgatcc     60

acggaccaca tgttgagaaa ctgcagtcac ccttagggcc acaccgtccc tctcctcgct    120

gtcccctctc tgtagtgact ggccctgacc ttcaggagtg cactttccac tctaccagga    180

agccctatga catcctcagg ctccccagac ctgcagcttg catggggccc ctcccttctt    240

ccacacccac cctccgtatg gtcccctgct ctgccctcgt gctttgctgg cccctgcccg    300

ctactcccac tctcagacac ccaggggtgg tgggccctaa ctggctggcc cctcccagcg    360

ctgccctctg ccgtccagat gctgcagtgt ggccagattt accttccagt aacatacttc    420

tagtcacccc tcctcctgcg aagtgatctg cagtggctgt ttgaccagac cacaaagttc    480

acatctcctg agcttagtgt ccgtggctgt ccacctccca gccatacttg actgtcccca    540

aactctccct gcagccacat gtttcccatg acctgtgggc tctgcagatg gacctctctc    600

cgctagagat gcccttctcc caaatggctt ccctcctgga aggcccagcc tgagtcctcg    660

tctcctttcc agtgcttctg ccagaagcat ccccatgatg ttgtgaccgc acagcacttt    720

gtgtctcgct ttgagcactt gccactctgg ctggtgctgc tgccactgat tgtgtactgt    780

cttgctgccc tttctagact gtgagctcct cgtgggcagg gaccgcctgt gttctctgta    840

tttcccacgg cgcctagcac agtgccttgc acttgatagg tgcttaataa atgtctgctc    900

a                                                                    901


<210>  5182
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  5182

Met Gln Val Ile His Gly Pro His Val Glu Lys Leu Gln Ser Pro Leu 
1               5                   10                  15      


Gly Pro His Arg Pro Ser Pro Arg Cys Pro Leu Ser Val Val Thr Gly 
            20                  25                  30          


Pro Asp Leu Gln Glu Cys Thr Phe His Ser Thr Arg Lys Pro Tyr Asp 
        35                  40                  45              


Ile Leu Arg Leu Pro Arg Pro Ala Ala Cys Met Gly Pro Leu Pro Ser 
    50                  55                  60                  


Ser Thr Pro Thr Leu Arg Met Val Pro Cys Ser Ala Leu Val Leu Cys 
65                  70                  75                  80  


Trp Pro Leu Pro Ala Thr Pro Thr Leu Arg His Pro Gly Val Val Gly 
                85                  90                  95      


Pro Asn Trp Leu Ala Pro Pro Ser Ala Ala Leu Cys Arg Pro Asp Ala 
            100                 105                 110         


Ala Val Trp Pro Asp Leu Pro Ser Ser Asn Ile Leu Leu Val Thr Pro 
        115                 120                 125             


Pro Pro Ala Lys 
    130         


<210>  5183
<211>  948
<212>  DNA
<213>  Homosapiens

<400>  5183
atgggatatg gagaccttgg aaaggagcag cctgcctgcc agctggacac aggccctgct     60

acacgtggct gtgtgagcca gggcaaggct gtgtgcgtct ctgaaactcc tttcctcaac    120

tggcaaatga agagggacaa cccctcccca gacccccaca acctactccc tggaaacttg    180

gaggtgcctg tgagagcctc tggaaccaca caccccaccc caaagcggag gcccgatcgg    240

ggttccggtg ccccagggct cccgaggcgc acatctggct ggcgggcccg cagcccaccc    300

aagggcggca ccagctgtgg gctcgacgcc gccgtcccca gcgctgggcc tgggaccagg    360

agtcctgagg gcgccagact ccgaggggcg ggcggccggg gggcggcccg cggcgcagaa    420

caagccaggc cccacccggg ccgcgtgagc gagctgcgca gcctgcgcct tcccagccgg    480

ccccccgccg cggccgcttt gtgcccgaac ctggccctga gtgactgcgc cgcagccatg    540

gagccctccc gcgcgggggg cggcccagcg cgttcccaat gccgccgcct caaaggggtc    600

ccggggccgc ccccgcgggc cgggcagaca agggcccggg aggggctgcg ttcccaagcg    660

tcggccgggc tcccctcggc ggaggagcgg gacatgacac tgaggtcccc agggcaagac    720

tgggaccctg aagcggcttc tgcccagaaa cagccccaag gaactgactc gcggccccag    780

gaaagcctcc agagagaaca gagccgggcc ccacccagcc tgctggctga agctgcagcc    840

tgcaccttcc cagccggctc gccgccctcc cagggaatcc agccaaagaa acactcaaac    900

aagaacacaa aggttataaa tgaggatact ccctgcatca tcatttaa                 948


<210>  5184
<211>  315
<212>  PRT
<213>  Homosapiens

<400>  5184

Met Gly Tyr Gly Asp Leu Gly Lys Glu Gln Pro Ala Cys Gln Leu Asp 
1               5                   10                  15      


Thr Gly Pro Ala Thr Arg Gly Cys Val Ser Gln Gly Lys Ala Val Cys 
            20                  25                  30          


Val Ser Glu Thr Pro Phe Leu Asn Trp Gln Met Lys Arg Asp Asn Pro 
        35                  40                  45              


Ser Pro Asp Pro His Asn Leu Leu Pro Gly Asn Leu Glu Val Pro Val 
    50                  55                  60                  


Arg Ala Ser Gly Thr Thr His Pro Thr Pro Lys Arg Arg Pro Asp Arg 
65                  70                  75                  80  


Gly Ser Gly Ala Pro Gly Leu Pro Arg Arg Thr Ser Gly Trp Arg Ala 
                85                  90                  95      


Arg Ser Pro Pro Lys Gly Gly Thr Ser Cys Gly Leu Asp Ala Ala Val 
            100                 105                 110         


Pro Ser Ala Gly Pro Gly Thr Arg Ser Pro Glu Gly Ala Arg Leu Arg 
        115                 120                 125             


Gly Ala Gly Gly Arg Gly Ala Ala Arg Gly Ala Glu Gln Ala Arg Pro 
    130                 135                 140                 


His Pro Gly Arg Val Ser Glu Leu Arg Ser Leu Arg Leu Pro Ser Arg 
145                 150                 155                 160 


Pro Pro Ala Ala Ala Ala Leu Cys Pro Asn Leu Ala Leu Ser Asp Cys 
                165                 170                 175     


Ala Ala Ala Met Glu Pro Ser Arg Ala Gly Gly Gly Pro Ala Arg Ser 
            180                 185                 190         


Gln Cys Arg Arg Leu Lys Gly Val Pro Gly Pro Pro Pro Arg Ala Gly 
        195                 200                 205             


Gln Thr Arg Ala Arg Glu Gly Leu Arg Ser Gln Ala Ser Ala Gly Leu 
    210                 215                 220                 


Pro Ser Ala Glu Glu Arg Asp Met Thr Leu Arg Ser Pro Gly Gln Asp 
225                 230                 235                 240 


Trp Asp Pro Glu Ala Ala Ser Ala Gln Lys Gln Pro Gln Gly Thr Asp 
                245                 250                 255     


Ser Arg Pro Gln Glu Ser Leu Gln Arg Glu Gln Ser Arg Ala Pro Pro 
            260                 265                 270         


Ser Leu Leu Ala Glu Ala Ala Ala Cys Thr Phe Pro Ala Gly Ser Pro 
        275                 280                 285             


Pro Ser Gln Gly Ile Gln Pro Lys Lys His Ser Asn Lys Asn Thr Lys 
    290                 295                 300                 


Val Ile Asn Glu Asp Thr Pro Cys Ile Ile Ile 
305                 310                 315 


<210>  5185
<211>  552
<212>  DNA
<213>  Homosapiens

<400>  5185
atgggccaga aggactccta tgtgggcgac gaggcccaga gcaagtacgg catcctgacc     60

ctgaaatatc ccatcgagca gggcatggtc acgaaccggg atgacatgga gaagatctgg    120

caccacacct tctacaacaa actgcgtctt caccccacgg ccgagtggga gatcgtgcgt    180

gacatcaagg agaagctgtg ctacgttacc ccggacatca agcgggagct ggccaccgcc    240

gtgttctcgt ccctggagaa gagctatgag ccacccgacg gccaggtcat caccatctgc    300

agccagtggg ccaagatgat gctgtcctgc ggcaccaccg tgtacctgga catcacgggc    360

aggatgcagg agatcaccac tctggcgccc agcaccatga agatcacaat catcgagtcc    420

cctgagcaca agtacatggt gtggattggc ggctccatcc tggcctccct gtctaccttc    480

cagcagatgt ggattagcaa gcaggagtac gaggagtcag ccccctccat catccaccgc    540

aaatgcttct aa                                                        552


<210>  5186
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  5186

Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Tyr 
1               5                   10                  15      


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu Gln Gly Met Val Thr Asn 
            20                  25                  30          


Arg Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Lys Leu 
        35                  40                  45              


Arg Leu His Pro Thr Ala Glu Trp Glu Ile Val Arg Asp Ile Lys Glu 
    50                  55                  60                  


Lys Leu Cys Tyr Val Thr Pro Asp Ile Lys Arg Glu Leu Ala Thr Ala 
65                  70                  75                  80  


Val Phe Ser Ser Leu Glu Lys Ser Tyr Glu Pro Pro Asp Gly Gln Val 
                85                  90                  95      


Ile Thr Ile Cys Ser Gln Trp Ala Lys Met Met Leu Ser Cys Gly Thr 
            100                 105                 110         


Thr Val Tyr Leu Asp Ile Thr Gly Arg Met Gln Glu Ile Thr Thr Leu 
        115                 120                 125             


Ala Pro Ser Thr Met Lys Ile Thr Ile Ile Glu Ser Pro Glu His Lys 
    130                 135                 140                 


Tyr Met Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
145                 150                 155                 160 


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Glu Glu Ser Ala Pro Ser 
                165                 170                 175     


Ile Ile His Arg Lys Cys Phe 
            180             


<210>  5187
<211>  552
<212>  DNA
<213>  Homosapiens

<400>  5187
atgggccaga aggactccta tgtgggcgac gaggcccaga gcaagtacgg catcctgacc     60

ctgaaatatc ccatcgagca gggcatggtc acgaaccggg atgacatgga gaagatctgg    120

caccacacct tctacaacaa actgcgtctt caccccacgg ccgagtggga gatcgtgcgt    180

gacatcaagg agaagctgtg ctacgttacc ccggacatca agcgggagct ggccaccgcc    240

gtgttctcgt ccctggagaa gagctatgag ccacccgacg gccaggtcat caccatctgc    300

agcgagtggg ccaagatgat gttgtcctgc ggcaccaccg tgtacctgga catcacgggc    360

aggatgcagg agatcaccac tctggcgccc agcaccatga agatcacaat catcgagtcc    420

cctgagcaca agtacatggt gtggattggc ggctccatcc tggcctccct gtctaccttc    480

cagcagatgt ggattagcaa gcaggagtac gaggagtcag ccccctccat catccaccgc    540

aaatgcttct aa                                                        552


<210>  5188
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  5188

Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Tyr 
1               5                   10                  15      


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu Gln Gly Met Val Thr Asn 
            20                  25                  30          


Arg Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Lys Leu 
        35                  40                  45              


Arg Leu His Pro Thr Ala Glu Trp Glu Ile Val Arg Asp Ile Lys Glu 
    50                  55                  60                  


Lys Leu Cys Tyr Val Thr Pro Asp Ile Lys Arg Glu Leu Ala Thr Ala 
65                  70                  75                  80  


Val Phe Ser Ser Leu Glu Lys Ser Tyr Glu Pro Pro Asp Gly Gln Val 
                85                  90                  95      


Ile Thr Ile Cys Ser Glu Trp Ala Lys Met Met Leu Ser Cys Gly Thr 
            100                 105                 110         


Thr Val Tyr Leu Asp Ile Thr Gly Arg Met Gln Glu Ile Thr Thr Leu 
        115                 120                 125             


Ala Pro Ser Thr Met Lys Ile Thr Ile Ile Glu Ser Pro Glu His Lys 
    130                 135                 140                 


Tyr Met Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
145                 150                 155                 160 


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Glu Glu Ser Ala Pro Ser 
                165                 170                 175     


Ile Ile His Arg Lys Cys Phe 
            180             


<210>  5189
<211>  1270
<212>  DNA
<213>  Homosapiens

<400>  5189
atgccggctc ctccccttca aaactctttg attactcatt gcctttctgt ggacttcgta     60

gttgttaaaa tcctattcta ccagggacaa accacaatct ctgcaggccc ttctccagtg    120

tactggactg ggtccaggac tgcaactagt gtggactttg ccgctcccaa gcccagagct    180

gctctgcgca agcgcgaccg accgagcagc tccgaggagt ccgcccggaa acaaacattc    240

cccagggcaa tgtcacgact tggtcttccc gaggagccag tcagaaacag tttgctagat    300

gatgctaagg cccgcttaag aaagtatgat attggaggca aatattctca cttgccatat    360

aacaaatact ccgtcctttt gccattggtg gctaaagaag gaaaactcca tttgttgttc    420

accgtccggt cagagaagct aagaagggcc cctggagaag tttgcttccc tggaggtaag    480

cgtgacccta cagacatgga tgatgcagcc acagctctcc gggaagccca ggaggaagtg    540

ggtctccgtc ctcaccaagt ggaagttgtc tgctgcctgg tgccatgtct tattgataca    600

gatacattga taactccatt tgtgggttta atagaccaca acttccaggc ccagccgaat    660

cctgctgaag ttaaggatgt attcctggtg cctctggcct atttcctgca tccacaggtc    720

catgaccagc attacgtcac acgtcttggt caccgtttta ttaatcatat ctttgagtac    780

acaaaccctg aagacggtgt cacttaccag atcaagggaa tgacggcaaa ccttgcagtg    840

ttggtggcct ttatcatttt ggaaaaaaaa cccacctttg aggttcaatt taatcttaat    900

gatgtattag catcctctga agagttattc ctgaaggttc ataaaaaagc tacaagcagg    960

ttatgattta ctagagcaag agacaaagaa ctattcacga ggattctgtg tgtgcttatt   1020

cgtagaacaa caacaatgcc agctgttgga atttgacagg tgtgaatatt ttttctgcag   1080

tatgtagtta gaatccttgc ctcttttcca gttgccttct attgtctgaa aaagtaaaag   1140

ccattcaaaa atgaaaacta tgttcatagt gttgcatatt ttcacccaca atatgttaat   1200

aatatttttc ttacacatat aataaagaat atctggcaca tactaggccc ttaataaaga   1260

ttttttgaat                                                          1270


<210>  5190
<211>  321
<212>  PRT
<213>  Homosapiens

<400>  5190

Met Pro Ala Pro Pro Leu Gln Asn Ser Leu Ile Thr His Cys Leu Ser 
1               5                   10                  15      


Val Asp Phe Val Val Val Lys Ile Leu Phe Tyr Gln Gly Gln Thr Thr 
            20                  25                  30          


Ile Ser Ala Gly Pro Ser Pro Val Tyr Trp Thr Gly Ser Arg Thr Ala 
        35                  40                  45              


Thr Ser Val Asp Phe Ala Ala Pro Lys Pro Arg Ala Ala Leu Arg Lys 
    50                  55                  60                  


Arg Asp Arg Pro Ser Ser Ser Glu Glu Ser Ala Arg Lys Gln Thr Phe 
65                  70                  75                  80  


Pro Arg Ala Met Ser Arg Leu Gly Leu Pro Glu Glu Pro Val Arg Asn 
                85                  90                  95      


Ser Leu Leu Asp Asp Ala Lys Ala Arg Leu Arg Lys Tyr Asp Ile Gly 
            100                 105                 110         


Gly Lys Tyr Ser His Leu Pro Tyr Asn Lys Tyr Ser Val Leu Leu Pro 
        115                 120                 125             


Leu Val Ala Lys Glu Gly Lys Leu His Leu Leu Phe Thr Val Arg Ser 
    130                 135                 140                 


Glu Lys Leu Arg Arg Ala Pro Gly Glu Val Cys Phe Pro Gly Gly Lys 
145                 150                 155                 160 


Arg Asp Pro Thr Asp Met Asp Asp Ala Ala Thr Ala Leu Arg Glu Ala 
                165                 170                 175     


Gln Glu Glu Val Gly Leu Arg Pro His Gln Val Glu Val Val Cys Cys 
            180                 185                 190         


Leu Val Pro Cys Leu Ile Asp Thr Asp Thr Leu Ile Thr Pro Phe Val 
        195                 200                 205             


Gly Leu Ile Asp His Asn Phe Gln Ala Gln Pro Asn Pro Ala Glu Val 
    210                 215                 220                 


Lys Asp Val Phe Leu Val Pro Leu Ala Tyr Phe Leu His Pro Gln Val 
225                 230                 235                 240 


His Asp Gln His Tyr Val Thr Arg Leu Gly His Arg Phe Ile Asn His 
                245                 250                 255     


Ile Phe Glu Tyr Thr Asn Pro Glu Asp Gly Val Thr Tyr Gln Ile Lys 
            260                 265                 270         


Gly Met Thr Ala Asn Leu Ala Val Leu Val Ala Phe Ile Ile Leu Glu 
        275                 280                 285             


Lys Lys Pro Thr Phe Glu Val Gln Phe Asn Leu Asn Asp Val Leu Ala 
    290                 295                 300                 


Ser Ser Glu Glu Leu Phe Leu Lys Val His Lys Lys Ala Thr Ser Arg 
305                 310                 315                 320 


Leu 
    


<210>  5191
<211>  1270
<212>  DNA
<213>  Homosapiens

<400>  5191
atgccggctc ctccccttca aaactctttg attactcatt gcctttctgt ggacttcgta     60

gttgttaaaa tcctattcta ccagggacaa accacaatct ctgcaggccc ttctccagtg    120

tactggactg ggtccaggac tgcaactagt gtggactttg ccgctcccaa gcccagagct    180

gctctgcgca agcgcgaccg accgagcagc tccgaggagt ccgcccggaa acaaacattc    240

cccagggcaa tgtcacgact tggtcttccc gaggagccag tcagaaacag tttgctagat    300

gatgctaagg cccgcttaag aaagtatgat attggaggca aatattctca cttgccatat    360

aacaaatact ccgtcctttt gccattggtg gctaaagaag gaaaactcca tttgttgttc    420

accgtccggt cagagaagct aagaagggcc cctggagaag tttgcttccc tggaggtaag    480

cgtgacccta cagacatgga tgatgcagcc acagctctcc gggaagccca ggaggaagtg    540

ggtctccgtc ctcaccaagt ggaagttgtc tgctgcctgg tgccatgtct tattgataca    600

gatacattga taactccatt tgtgggttta atagaccaca acttccaggc ccagccgaat    660

cctgctgaag ttaaggatgt attcctggtg cctctggcct atttcctgca tccacaggtc    720

catgaccagc attacgtcac acgtcttggt caccgtttta ttaatcatat ctttgagtac    780

acaaaccctg aagacggtgt cacttaccag atcaagggaa tgacggcaaa ccttgcagtg    840

ttggtggcct ttatcatttt ggaaaaaaaa cccacctttg aggttcaatt taatcttaat    900

gatgtattag catcctctga agagttattc ctgaaggttc ataaaaaagc tacaagcagg    960

ttatgattta ctagagcaag agacaaagaa ctattcacga ggattctgtg tgtgcttatt   1020

cgtagaacaa caacaatgcc agctgttgga atttgacagg tgtgaatatt ttttctgcag   1080

tatgtagtta gaatccttgc ctcttttcca gttgccttct attgtctgaa aaagtaaaag   1140

ccattcaaaa atgaaaacta tgttcatagt gttgcatatt ttcacccaca atatgttaat   1200

aatatttttc ttacacatat aataaagaat atctggcaca tactaggccc ttaataaaga   1260

ttttttgaat                                                          1270


<210>  5192
<211>  321
<212>  PRT
<213>  Homosapiens

<400>  5192

Met Pro Ala Pro Pro Leu Gln Asn Ser Leu Ile Thr His Cys Leu Ser 
1               5                   10                  15      


Val Asp Phe Val Val Val Lys Ile Leu Phe Tyr Gln Gly Gln Thr Thr 
            20                  25                  30          


Ile Ser Ala Gly Pro Ser Pro Val Tyr Trp Thr Gly Ser Arg Thr Ala 
        35                  40                  45              


Thr Ser Val Asp Phe Ala Ala Pro Lys Pro Arg Ala Ala Leu Arg Lys 
    50                  55                  60                  


Arg Asp Arg Pro Ser Ser Ser Glu Glu Ser Ala Arg Lys Gln Thr Phe 
65                  70                  75                  80  


Pro Arg Ala Met Ser Arg Leu Gly Leu Pro Glu Glu Pro Val Arg Asn 
                85                  90                  95      


Ser Leu Leu Asp Asp Ala Lys Ala Arg Leu Arg Lys Tyr Asp Ile Gly 
            100                 105                 110         


Gly Lys Tyr Ser His Leu Pro Tyr Asn Lys Tyr Ser Val Leu Leu Pro 
        115                 120                 125             


Leu Val Ala Lys Glu Gly Lys Leu His Leu Leu Phe Thr Val Arg Ser 
    130                 135                 140                 


Glu Lys Leu Arg Arg Ala Pro Gly Glu Val Cys Phe Pro Gly Gly Lys 
145                 150                 155                 160 


Arg Asp Pro Thr Asp Met Asp Asp Ala Ala Thr Ala Leu Arg Glu Ala 
                165                 170                 175     


Gln Glu Glu Val Gly Leu Arg Pro His Gln Val Glu Val Val Cys Cys 
            180                 185                 190         


Leu Val Pro Cys Leu Ile Asp Thr Asp Thr Leu Ile Thr Pro Phe Val 
        195                 200                 205             


Gly Leu Ile Asp His Asn Phe Gln Ala Gln Pro Asn Pro Ala Glu Val 
    210                 215                 220                 


Lys Asp Val Phe Leu Val Pro Leu Ala Tyr Phe Leu His Pro Gln Val 
225                 230                 235                 240 


His Asp Gln His Tyr Val Thr Arg Leu Gly His Arg Phe Ile Asn His 
                245                 250                 255     


Ile Phe Glu Tyr Thr Asn Pro Glu Asp Gly Val Thr Tyr Gln Ile Lys 
            260                 265                 270         


Gly Met Thr Ala Asn Leu Ala Val Leu Val Ala Phe Ile Ile Leu Glu 
        275                 280                 285             


Lys Lys Pro Thr Phe Glu Val Gln Phe Asn Leu Asn Asp Val Leu Ala 
    290                 295                 300                 


Ser Ser Glu Glu Leu Phe Leu Lys Val His Lys Lys Ala Thr Ser Arg 
305                 310                 315                 320 


Leu 
    


<210>  5193
<211>  729
<212>  DNA
<213>  Homosapiens

<400>  5193
atggtgagga gtggagggcc gcccatcccc tccaacaagg aacccgctga aggggagggg     60

aaggtgctct gcagaggcag gtgccctccc cgtcttcctc tcccctcgcc ccaccggagc    120

ttccctagtg agggggacgg ccagaaactg aaagagaaac ttgacggcgg gaggcccaca    180

ggccccctgg agagggctgc aaggatcccc cagcccacct cgggcccggt ttctgggaag    240

gggagatatt ccaacccgaa gttaggccag cgccacgacg gctcccactc gacggctagg    300

gcttttcggt gcctccccgg gtccagcccg acaggtgctc cctctccgag gcgtgccagg    360

acggcgccct ccctggcctc tgcctttcat ccccgacccc tgtccccacg tccccccgtc    420

cctcgtctgc gctgggccaa ctccctcgca gtgccgggga ctgatccccg cgctgcgccc    480

ggccgtcgag ctccgggtgc cggaggtgcc ggggcggcag tagagtgtcc cctctcggcg    540

cgccgccgag gacgcgccac cgggtcaccc acctggtggg gccgcaccgt ccggcagccg    600

ggccggctct gcgccccgcg gctctcgctc ccggccgggg ttcctggcgg cggcggcagc    660

ggcggctgtt actacaggaa ggagcggaga gcagcgattt cctcctcaaa ggtcagctgc    720

ctgcgatag                                                            729


<210>  5194
<211>  242
<212>  PRT
<213>  Homosapiens

<400>  5194

Met Val Arg Ser Gly Gly Pro Pro Ile Pro Ser Asn Lys Glu Pro Ala 
1               5                   10                  15      


Glu Gly Glu Gly Lys Val Leu Cys Arg Gly Arg Cys Pro Pro Arg Leu 
            20                  25                  30          


Pro Leu Pro Ser Pro His Arg Ser Phe Pro Ser Glu Gly Asp Gly Gln 
        35                  40                  45              


Lys Leu Lys Glu Lys Leu Asp Gly Gly Arg Pro Thr Gly Pro Leu Glu 
    50                  55                  60                  


Arg Ala Ala Arg Ile Pro Gln Pro Thr Ser Gly Pro Val Ser Gly Lys 
65                  70                  75                  80  


Gly Arg Tyr Ser Asn Pro Lys Leu Gly Gln Arg His Asp Gly Ser His 
                85                  90                  95      


Ser Thr Ala Arg Ala Phe Arg Cys Leu Pro Gly Ser Ser Pro Thr Gly 
            100                 105                 110         


Ala Pro Ser Pro Arg Arg Ala Arg Thr Ala Pro Ser Leu Ala Ser Ala 
        115                 120                 125             


Phe His Pro Arg Pro Leu Ser Pro Arg Pro Pro Val Pro Arg Leu Arg 
    130                 135                 140                 


Trp Ala Asn Ser Leu Ala Val Pro Gly Thr Asp Pro Arg Ala Ala Pro 
145                 150                 155                 160 


Gly Arg Arg Ala Pro Gly Ala Gly Gly Ala Gly Ala Ala Val Glu Cys 
                165                 170                 175     


Pro Leu Ser Ala Arg Arg Arg Gly Arg Ala Thr Gly Ser Pro Thr Trp 
            180                 185                 190         


Trp Gly Arg Thr Val Arg Gln Pro Gly Arg Leu Cys Ala Pro Arg Leu 
        195                 200                 205             


Ser Leu Pro Ala Gly Val Pro Gly Gly Gly Gly Ser Gly Gly Cys Tyr 
    210                 215                 220                 


Tyr Arg Lys Glu Arg Arg Ala Ala Ile Ser Ser Ser Lys Val Ser Cys 
225                 230                 235                 240 


Leu Arg 
        


<210>  5195
<211>  729
<212>  DNA
<213>  Homosapiens

<400>  5195
atggtgagga gtggagggcc gcccatcccc tccaacaagg aacccgctga aggggagggg     60

aaggtgctct gcagaggcag gtgccctccc cgtcttcctc tcccctcgcc ccaccggagc    120

ttccctagtg agggggacgg ccagaaactg aaagagaaac ttgacggcgg gaggcccaca    180

ggccccctgg agagggctgc aaggatcccc cagcccacct cgggcccggt ttctgggaag    240

gggagatatt ccaacccgaa gttaggccag cgccacgacg gctcccactc gacggctagg    300

gcttttcggt gcctccccgg gtccagcccg acaggtgctc cctctccgag gcgtgccagg    360

acggcgccct ccctggcctc tgcctttcat ccccgacccc tgtccccacg tccccccgtc    420

cctcgtctgc gctgggccaa ctccctcgca gtgccgggga ctgatccccg cgctgcgccc    480

ggccgtcgag ctccgggtgc cggaggtgcc ggggcggcag tagagtgtcc cctctcggcg    540

cgccgccgag gacgcgccac cgggtcaccc acctggtggg gccgcaccgt ccggcagccg    600

ggccggctct gcgccccgcg gctctcgctc ccggccgggg ttcctggcgg cggcggcagc    660

ggcggctgtt actacaggaa ggagcggaga gcagcgattt cctcctcaaa ggtcagctgc    720

ctgcgatag                                                            729


<210>  5196
<211>  242
<212>  PRT
<213>  Homosapiens

<400>  5196

Met Val Arg Ser Gly Gly Pro Pro Ile Pro Ser Asn Lys Glu Pro Ala 
1               5                   10                  15      


Glu Gly Glu Gly Lys Val Leu Cys Arg Gly Arg Cys Pro Pro Arg Leu 
            20                  25                  30          


Pro Leu Pro Ser Pro His Arg Ser Phe Pro Ser Glu Gly Asp Gly Gln 
        35                  40                  45              


Lys Leu Lys Glu Lys Leu Asp Gly Gly Arg Pro Thr Gly Pro Leu Glu 
    50                  55                  60                  


Arg Ala Ala Arg Ile Pro Gln Pro Thr Ser Gly Pro Val Ser Gly Lys 
65                  70                  75                  80  


Gly Arg Tyr Ser Asn Pro Lys Leu Gly Gln Arg His Asp Gly Ser His 
                85                  90                  95      


Ser Thr Ala Arg Ala Phe Arg Cys Leu Pro Gly Ser Ser Pro Thr Gly 
            100                 105                 110         


Ala Pro Ser Pro Arg Arg Ala Arg Thr Ala Pro Ser Leu Ala Ser Ala 
        115                 120                 125             


Phe His Pro Arg Pro Leu Ser Pro Arg Pro Pro Val Pro Arg Leu Arg 
    130                 135                 140                 


Trp Ala Asn Ser Leu Ala Val Pro Gly Thr Asp Pro Arg Ala Ala Pro 
145                 150                 155                 160 


Gly Arg Arg Ala Pro Gly Ala Gly Gly Ala Gly Ala Ala Val Glu Cys 
                165                 170                 175     


Pro Leu Ser Ala Arg Arg Arg Gly Arg Ala Thr Gly Ser Pro Thr Trp 
            180                 185                 190         


Trp Gly Arg Thr Val Arg Gln Pro Gly Arg Leu Cys Ala Pro Arg Leu 
        195                 200                 205             


Ser Leu Pro Ala Gly Val Pro Gly Gly Gly Gly Ser Gly Gly Cys Tyr 
    210                 215                 220                 


Tyr Arg Lys Glu Arg Arg Ala Ala Ile Ser Ser Ser Lys Val Ser Cys 
225                 230                 235                 240 


Leu Arg 
        


<210>  5197
<211>  447
<212>  DNA
<213>  Homosapiens

<400>  5197
atgaggtggt acgagcggtc tgaatctgta gacttagaca ggcttcaggt atctggggaa     60

ccatctgctc tcctcattgg tcagtgggcg gggcttcggc tgtaccgcac acgcactggg    120

acctctgggt ggccgaacga gctggccttt catgaattat gcatgacggc gtgcctcggc    180

caggctgggg ctgggcgagg attggctgaa ggggctgtaa ttcagcggtt tccggagctg    240

cggcggcgca gactgggagg gggagccggg ggttccgacg tcgcagccga gggaacaagc    300

cccaaccgga tcctggacag gcaccccggc ttggcgctgt ctctccccct cggctcggag    360

aggcccttcg gcctgaggga gcctcgccgc ccgtccccgg cacacgcgca gccccggcct    420

ctcggcctct gccggagaaa caggtga                                        447


<210>  5198
<211>  148
<212>  PRT
<213>  Homosapiens

<400>  5198

Met Arg Trp Tyr Glu Arg Ser Glu Ser Val Asp Leu Asp Arg Leu Gln 
1               5                   10                  15      


Val Ser Gly Glu Pro Ser Ala Leu Leu Ile Gly Gln Trp Ala Gly Leu 
            20                  25                  30          


Arg Leu Tyr Arg Thr Arg Thr Gly Thr Ser Gly Trp Pro Asn Glu Leu 
        35                  40                  45              


Ala Phe His Glu Leu Cys Met Thr Ala Cys Leu Gly Gln Ala Gly Ala 
    50                  55                  60                  


Gly Arg Gly Leu Ala Glu Gly Ala Val Ile Gln Arg Phe Pro Glu Leu 
65                  70                  75                  80  


Arg Arg Arg Arg Leu Gly Gly Gly Ala Gly Gly Ser Asp Val Ala Ala 
                85                  90                  95      


Glu Gly Thr Ser Pro Asn Arg Ile Leu Asp Arg His Pro Gly Leu Ala 
            100                 105                 110         


Leu Ser Leu Pro Leu Gly Ser Glu Arg Pro Phe Gly Leu Arg Glu Pro 
        115                 120                 125             


Arg Arg Pro Ser Pro Ala His Ala Gln Pro Arg Pro Leu Gly Leu Cys 
    130                 135                 140                 


Arg Arg Asn Arg 
145             


<210>  5199
<211>  447
<212>  DNA
<213>  Homosapiens

<400>  5199
atgaggtggt acgagcggtc tgaatctgta gacttagaca ggcttcaggt atctggggaa     60

ccatctgctc tcctcattgg tcagtgggcg gggcttcggc tgtaccgcac acgcactggg    120

acctctgggt ggccgaacga gctggccttt catgaattat gcatgacggc gtgcctcggc    180

caggctgggg ctgggcgagg attggctgaa ggggctgtaa ttcagcggtt tccggagctg    240

cggcggcgca gactgggagg gggagccggg ggttccgacg tcgcagccga gggaacaagc    300

cccaaccgga tcctggacag gcaccccggc ttggcgctgt ctctccccct cggctcggag    360

aggcccttcg gcctgaggga gcctcgccgc ccgtccccgg cacacgcgca gccccggcct    420

ctcggcctct gccggagaaa caggtga                                        447


<210>  5200
<211>  148
<212>  PRT
<213>  Homosapiens

<400>  5200

Met Arg Trp Tyr Glu Arg Ser Glu Ser Val Asp Leu Asp Arg Leu Gln 
1               5                   10                  15      


Val Ser Gly Glu Pro Ser Ala Leu Leu Ile Gly Gln Trp Ala Gly Leu 
            20                  25                  30          


Arg Leu Tyr Arg Thr Arg Thr Gly Thr Ser Gly Trp Pro Asn Glu Leu 
        35                  40                  45              


Ala Phe His Glu Leu Cys Met Thr Ala Cys Leu Gly Gln Ala Gly Ala 
    50                  55                  60                  


Gly Arg Gly Leu Ala Glu Gly Ala Val Ile Gln Arg Phe Pro Glu Leu 
65                  70                  75                  80  


Arg Arg Arg Arg Leu Gly Gly Gly Ala Gly Gly Ser Asp Val Ala Ala 
                85                  90                  95      


Glu Gly Thr Ser Pro Asn Arg Ile Leu Asp Arg His Pro Gly Leu Ala 
            100                 105                 110         


Leu Ser Leu Pro Leu Gly Ser Glu Arg Pro Phe Gly Leu Arg Glu Pro 
        115                 120                 125             


Arg Arg Pro Ser Pro Ala His Ala Gln Pro Arg Pro Leu Gly Leu Cys 
    130                 135                 140                 


Arg Arg Asn Arg 
145             


<210>  5201
<211>  278
<212>  DNA
<213>  Homosapiens

<400>  5201
ccaatgggtc atgtttggtt agaaggtgat aatctacaga attctatgga ttccaggtac     60

tatggaccta ttccgtatgg actaataaga ggacgaatct tctttaagat ttggcctctg    120

agtgattttg gatttttacg tgccagccct aatggccaca gattttctga cgattagtaa    180

gtatttattc ttttgactta attattgtct ccttttcatg tgaatttatt actcccgttg    240

aaatcatgta cttaccaata aactatttgc tattcaaa                            278


<210>  5202
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  5202

Met Gly His Val Trp Leu Glu Gly Asp Asn Leu Gln Asn Ser Met Asp 
1               5                   10                  15      


Ser Arg Tyr Tyr Gly Pro Ile Pro Tyr Gly Leu Ile Arg Gly Arg Ile 
            20                  25                  30          


Phe Phe Lys Ile Trp Pro Leu Ser Asp Phe Gly Phe Leu Arg Ala Ser 
        35                  40                  45              


Pro Asn Gly His Arg Phe Ser Asp Asp 
    50                  55          


<210>  5203
<211>  786
<212>  DNA
<213>  Homosapiens

<400>  5203
atgacacctg caaagaccct gcttctaaag aagttcatgt tcacagggcc tctgatgagc     60

tatattgggc ccacctgcct gggttccagc agcttccgca gccccagcag gagacggaag    120

atgcaagagg tcattgcggg gctagagcgg ttcacctttg ccttcgagaa ggatgtcgag    180

atgcagaagg gcactgggct cctgcctttc cagggcatgg acaagtcggc ctcagctgtg    240

tgcaacttct tcactaaagg gctctgtgag aaagggaaac tctgcccctt ccgacatgac    300

cgaggggaga agatggtggt atgcaagcac tggctccggg ggctctgcaa gaagggtgat    360

cactgcaagt tcctgcacca gtatgacctc accaggatgc ctgagtgcta cttctactcc    420

aagtttggtg actgcagcaa caaggagtgt tccttcctcc atgtgaagcc agctttcaag    480

tcccaggact gtccttggta tgaccaaggt ttctgcaagg acggtcctct gtgtaaatac    540

cgccatgtcc ccagaataat gtgtctcaac tatttagttg gcttctgccc cgagggaccc    600

aagtgccaat ttgctcatcc caagatgaat cttttactca acccgagtta catgaaggct    660

ttgaaagaag gtgggaggcg atctgtggga ctgcggggaa tttacaagcc catttacaat    720

gaaagcctaa ctttgatgga aaggaagatt cgggaattca agctgctgcc tggaagcaag    780

atctaa                                                               786


<210>  5204
<211>  261
<212>  PRT
<213>  Homosapiens

<400>  5204

Met Thr Pro Ala Lys Thr Leu Leu Leu Lys Lys Phe Met Phe Thr Gly 
1               5                   10                  15      


Pro Leu Met Ser Tyr Ile Gly Pro Thr Cys Leu Gly Ser Ser Ser Phe 
            20                  25                  30          


Arg Ser Pro Ser Arg Arg Arg Lys Met Gln Glu Val Ile Ala Gly Leu 
        35                  40                  45              


Glu Arg Phe Thr Phe Ala Phe Glu Lys Asp Val Glu Met Gln Lys Gly 
    50                  55                  60                  


Thr Gly Leu Leu Pro Phe Gln Gly Met Asp Lys Ser Ala Ser Ala Val 
65                  70                  75                  80  


Cys Asn Phe Phe Thr Lys Gly Leu Cys Glu Lys Gly Lys Leu Cys Pro 
                85                  90                  95      


Phe Arg His Asp Arg Gly Glu Lys Met Val Val Cys Lys His Trp Leu 
            100                 105                 110         


Arg Gly Leu Cys Lys Lys Gly Asp His Cys Lys Phe Leu His Gln Tyr 
        115                 120                 125             


Asp Leu Thr Arg Met Pro Glu Cys Tyr Phe Tyr Ser Lys Phe Gly Asp 
    130                 135                 140                 


Cys Ser Asn Lys Glu Cys Ser Phe Leu His Val Lys Pro Ala Phe Lys 
145                 150                 155                 160 


Ser Gln Asp Cys Pro Trp Tyr Asp Gln Gly Phe Cys Lys Asp Gly Pro 
                165                 170                 175     


Leu Cys Lys Tyr Arg His Val Pro Arg Ile Met Cys Leu Asn Tyr Leu 
            180                 185                 190         


Val Gly Phe Cys Pro Glu Gly Pro Lys Cys Gln Phe Ala His Pro Lys 
        195                 200                 205             


Met Asn Leu Leu Leu Asn Pro Ser Tyr Met Lys Ala Leu Lys Glu Gly 
    210                 215                 220                 


Gly Arg Arg Ser Val Gly Leu Arg Gly Ile Tyr Lys Pro Ile Tyr Asn 
225                 230                 235                 240 


Glu Ser Leu Thr Leu Met Glu Arg Lys Ile Arg Glu Phe Lys Leu Leu 
                245                 250                 255     


Pro Gly Ser Lys Ile 
            260     


<210>  5205
<211>  804
<212>  DNA
<213>  Homosapiens

<400>  5205
atgacacctg caaagaccct gcttctaaag aagttcatgt tcacagggcc tctgatgagc     60

tatattgggc ccacctgcct gggttccagc agcttccgca gccccagcag gagacggaag    120

atgcaagagg tcattgcggg gctagagcgg ttcacctttg ccttcgagaa ggatgtcgag    180

atgcagaagg gcactgggct cctgcctttc cagggcatgg acaagtcggc ctcagctgtg    240

tgcaacttct tcactaaagg gctctgtgag aaagggaaac tctgcccctt ccgacatgac    300

cgaggggaga agatggtggt atgcaagcac tggctccggg ggctctgcaa gaagggtgat    360

cactgcaagt tcctgcacca gtatgacctc accaggatgc ctgagtgcta cttctactcc    420

aagtttggtg actgcagcaa caaggagtgt tccttcctcc atgtgaagcc agctttcaag    480

tcccaggact gtccttggta tgaccaaggt ttctgcaagg acggtcctct gtgtaaatac    540

cgccatgtcc ccagaataat gtgtctcaac tatttagttg gcttctgccc cgagggaccc    600

aagtgccaat ttgctcatcc caagatgaat cttttactca acccgagtta catgaaggaa    660

gattcgggaa ttcaagctgc tgcctggaag caagatctaa gcattgcttc ttacctagcg    720

gggcactcca atgccacaga cagggcagaa cacgactttt accccctcct tctgcagcat    780

gattttaaga gacaaaactt ataa                                           804


<210>  5206
<211>  267
<212>  PRT
<213>  Homosapiens

<400>  5206

Met Thr Pro Ala Lys Thr Leu Leu Leu Lys Lys Phe Met Phe Thr Gly 
1               5                   10                  15      


Pro Leu Met Ser Tyr Ile Gly Pro Thr Cys Leu Gly Ser Ser Ser Phe 
            20                  25                  30          


Arg Ser Pro Ser Arg Arg Arg Lys Met Gln Glu Val Ile Ala Gly Leu 
        35                  40                  45              


Glu Arg Phe Thr Phe Ala Phe Glu Lys Asp Val Glu Met Gln Lys Gly 
    50                  55                  60                  


Thr Gly Leu Leu Pro Phe Gln Gly Met Asp Lys Ser Ala Ser Ala Val 
65                  70                  75                  80  


Cys Asn Phe Phe Thr Lys Gly Leu Cys Glu Lys Gly Lys Leu Cys Pro 
                85                  90                  95      


Phe Arg His Asp Arg Gly Glu Lys Met Val Val Cys Lys His Trp Leu 
            100                 105                 110         


Arg Gly Leu Cys Lys Lys Gly Asp His Cys Lys Phe Leu His Gln Tyr 
        115                 120                 125             


Asp Leu Thr Arg Met Pro Glu Cys Tyr Phe Tyr Ser Lys Phe Gly Asp 
    130                 135                 140                 


Cys Ser Asn Lys Glu Cys Ser Phe Leu His Val Lys Pro Ala Phe Lys 
145                 150                 155                 160 


Ser Gln Asp Cys Pro Trp Tyr Asp Gln Gly Phe Cys Lys Asp Gly Pro 
                165                 170                 175     


Leu Cys Lys Tyr Arg His Val Pro Arg Ile Met Cys Leu Asn Tyr Leu 
            180                 185                 190         


Val Gly Phe Cys Pro Glu Gly Pro Lys Cys Gln Phe Ala His Pro Lys 
        195                 200                 205             


Met Asn Leu Leu Leu Asn Pro Ser Tyr Met Lys Glu Asp Ser Gly Ile 
    210                 215                 220                 


Gln Ala Ala Ala Trp Lys Gln Asp Leu Ser Ile Ala Ser Tyr Leu Ala 
225                 230                 235                 240 


Gly His Ser Asn Ala Thr Asp Arg Ala Glu His Asp Phe Tyr Pro Leu 
                245                 250                 255     


Leu Leu Gln His Asp Phe Lys Arg Gln Asn Leu 
            260                 265         


<210>  5207
<211>  234
<212>  DNA
<213>  Homosapiens

<400>  5207
atgagttctg tgaatgtggg aaaaccttca gctgcaaata tggacttgtt cctcaccagt     60

gaattcacac tggagaaaga ccttattagt gcagggaaca tgggaaattc tttagccaaa    120

gttccagttt tactgaacaa caaagaattc acgctggaga aaggtcttat taatgcagca    180

aaaatggaaa attctctgtc catgtacaca gaaatatctt cagggatgga ttaa          234


<210>  5208
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  5208

Met Ser Ser Val Asn Val Gly Lys Pro Ser Ala Ala Asn Met Asp Leu 
1               5                   10                  15      


Phe Leu Thr Ser Glu Phe Thr Leu Glu Lys Asp Leu Ile Ser Ala Gly 
            20                  25                  30          


Asn Met Gly Asn Ser Leu Ala Lys Val Pro Val Leu Leu Asn Asn Lys 
        35                  40                  45              


Glu Phe Thr Leu Glu Lys Gly Leu Ile Asn Ala Ala Lys Met Glu Asn 
    50                  55                  60                  


Ser Leu Ser Met Tyr Thr Glu Ile Ser Ser Gly Met Asp 
65                  70                  75          


<210>  5209
<211>  234
<212>  DNA
<213>  Homosapiens

<400>  5209
atgagttctg tgaatgtggg aaaaccttca gctgcaaata tggacttgtt cctcaccagt     60

gaattcacac tggagaaaga ccttattagt gcagggaaca tgggaaattc tttagccaaa    120

gttccagttt tactgaacaa caaagaattc acgctggaga aaggtcttat taatgcagca    180

aaaatggaaa attctctgtc catgtacaca gaaatatctt cagggatgga ttaa          234


<210>  5210
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  5210

Met Ser Ser Val Asn Val Gly Lys Pro Ser Ala Ala Asn Met Asp Leu 
1               5                   10                  15      


Phe Leu Thr Ser Glu Phe Thr Leu Glu Lys Asp Leu Ile Ser Ala Gly 
            20                  25                  30          


Asn Met Gly Asn Ser Leu Ala Lys Val Pro Val Leu Leu Asn Asn Lys 
        35                  40                  45              


Glu Phe Thr Leu Glu Lys Gly Leu Ile Asn Ala Ala Lys Met Glu Asn 
    50                  55                  60                  


Ser Leu Ser Met Tyr Thr Glu Ile Ser Ser Gly Met Asp 
65                  70                  75          


<210>  5211
<211>  1254
<212>  DNA
<213>  Homosapiens

<400>  5211
atgaggagga gtggggtcta caactccctc ctctgccaat ggtttttggt acttgtattt     60

gctgatgaca caagaggtgt gcagaaagct gagaatagta cctggataat gcaagaacta    120

aaggaaaaac tgaagaaggg aggagccagc actggcccag ggaaacttgg agcaacagac    180

tacagatcca aaacccagag gatgtatcag accttggtgt catttgtgcc tactccctcc    240

tatcacccat taatcgctgt gtctgtgctc aacaataaga agcagtcaat ctcagccatc    300

cagaacaaca tgcaggtttt agatacctcc ccgcaaactg ctgccctcct aatgcctcta    360

gcagacaacc acatttgccc ctgtgctaat ccactatcct ggcgagtccg tagagctgtg    420

aagaacctgt gggaagaggt agaccttgag aagcaggcaa ctatgggagg actccatggg    480

cttaggcctc tcttgaacat ctgcccagtg gtggaaacag acctgaccca gccctctgta    540

gtttctgaac aggtaaaaca gctgcaaggc agccaaaatg accgccacaa agtgagacag    600

gaagtcctga ccatcttcac ccctaaacct ggaatctccc atctttctgt gctttcattg    660

gataagcact gctgccactc agcagagaat tctgggccgg aggtgcacac aaaggcgcag    720

atcctggagc tgctggtgct ggagcagttc ctggccatcc tcccagaaaa gctgcagccc    780

tgggtgcaga ggcatcatcc agaaaatgga gaggaagctc tgactatgct ggaggatgtg    840

cagagagcgc ttgatggacc aaagcagatc ttcttttttg gacgaaggag ggacacggtt    900

gcagagaagc tagcaccttc agaaatcact gagcaattgc caactagcca gcgcacgccc    960

gtgaagaagc agctccagcg agaatcatgg gagctgcagt ccttaagacc acatgatgaa   1020

gacatcaaaa ctataaatgt gaaatccgct tcaaggcaaa agacttcttc aggcatagaa   1080

ctgcattgcg atgtttcgaa catcctcggt ataaatgcct cccagagttc cacatataga   1140

ggaatgtatg aacaagatga ttcaaaatat gaacatagga ttgcagagtc ccaaaagaat   1200

atgtacttca agactaggct gaagtgtccc aggtcactgt caggaggcag ataa         1254


<210>  5212
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  5212

Met Arg Arg Ser Gly Val Tyr Asn Ser Leu Leu Cys Gln Trp Phe Leu 
1               5                   10                  15      


Val Leu Val Phe Ala Asp Asp Thr Arg Gly Val Gln Lys Ala Glu Asn 
            20                  25                  30          


Ser Thr Trp Ile Met Gln Glu Leu Lys Glu Lys Leu Lys Lys Gly Gly 
        35                  40                  45              


Ala Ser Thr Gly Pro Gly Lys Leu Gly Ala Thr Asp Tyr Arg Ser Lys 
    50                  55                  60                  


Thr Gln Arg Met Tyr Gln Thr Leu Val Ser Phe Val Pro Thr Pro Ser 
65                  70                  75                  80  


Tyr His Pro Leu Ile Ala Val Ser Val Leu Asn Asn Lys Lys Gln Ser 
                85                  90                  95      


Ile Ser Ala Ile Gln Asn Asn Met Gln Val Leu Asp Thr Ser Pro Gln 
            100                 105                 110         


Thr Ala Ala Leu Leu Met Pro Leu Ala Asp Asn His Ile Cys Pro Cys 
        115                 120                 125             


Ala Asn Pro Leu Ser Trp Arg Val Arg Arg Ala Val Lys Asn Leu Trp 
    130                 135                 140                 


Glu Glu Val Asp Leu Glu Lys Gln Ala Thr Met Gly Gly Leu His Gly 
145                 150                 155                 160 


Leu Arg Pro Leu Leu Asn Ile Cys Pro Val Val Glu Thr Asp Leu Thr 
                165                 170                 175     


Gln Pro Ser Val Val Ser Glu Gln Val Lys Gln Leu Gln Gly Ser Gln 
            180                 185                 190         


Asn Asp Arg His Lys Val Arg Gln Glu Val Leu Thr Ile Phe Thr Pro 
        195                 200                 205             


Lys Pro Gly Ile Ser His Leu Ser Val Leu Ser Leu Asp Lys His Cys 
    210                 215                 220                 


Cys His Ser Ala Glu Asn Ser Gly Pro Glu Val His Thr Lys Ala Gln 
225                 230                 235                 240 


Ile Leu Glu Leu Leu Val Leu Glu Gln Phe Leu Ala Ile Leu Pro Glu 
                245                 250                 255     


Lys Leu Gln Pro Trp Val Gln Arg His His Pro Glu Asn Gly Glu Glu 
            260                 265                 270         


Ala Leu Thr Met Leu Glu Asp Val Gln Arg Ala Leu Asp Gly Pro Lys 
        275                 280                 285             


Gln Ile Phe Phe Phe Gly Arg Arg Arg Asp Thr Val Ala Glu Lys Leu 
    290                 295                 300                 


Ala Pro Ser Glu Ile Thr Glu Gln Leu Pro Thr Ser Gln Arg Thr Pro 
305                 310                 315                 320 


Val Lys Lys Gln Leu Gln Arg Glu Ser Trp Glu Leu Gln Ser Leu Arg 
                325                 330                 335     


Pro His Asp Glu Asp Ile Lys Thr Ile Asn Val Lys Ser Ala Ser Arg 
            340                 345                 350         


Gln Lys Thr Ser Ser Gly Ile Glu Leu His Cys Asp Val Ser Asn Ile 
        355                 360                 365             


Leu Gly Ile Asn Ala Ser Gln Ser Ser Thr Tyr Arg Gly Met Tyr Glu 
    370                 375                 380                 


Gln Asp Asp Ser Lys Tyr Glu His Arg Ile Ala Glu Ser Gln Lys Asn 
385                 390                 395                 400 


Met Tyr Phe Lys Thr Arg Leu Lys Cys Pro Arg Ser Leu Ser Gly Gly 
                405                 410                 415     


Arg 
    


<210>  5213
<211>  1254
<212>  DNA
<213>  Homosapiens

<400>  5213
atgaggagga gtggggtcta caactccctc ctctgccaat ggtttttggt acttgtattt     60

gctgatgaca caagaggtgt gcagaaagct gagaatagta cctggataat gcaagaacta    120

aaggaaaaac tgaagaaggg aggagccagc actggcccag ggaaacttgg agcaacagac    180

tacagatcca aaacccagag gatgtatcag accttggtgt catttgtgcc tactccctcc    240

tatcacccat taatcgctgt gtctgtgctc aacaataaga agcagtcaat ctcagccatc    300

cagaacaaca tgcaggtttt agatacctcc ccgcaaactg ctgccctcct aatgcctcta    360

gcagacaacc acatttgccc ctgtgctaat ccactatcct ggcgagtccg tagagctgtg    420

aagaacctgt gggaagaggt agaccttgag aagcaggcaa ctatgggagg actccatggg    480

cttaggcctc tcttgaacat ctgcccagtg gtggaaacag acctgaccca gccctctgta    540

gtttctgaac aggtaaaaca gctgcaaggc agccaaaatg accgccacaa agtgagacag    600

gaagtcctga ccatcttcac ccctaaacct ggaatctccc atctttctgt gctttcattg    660

gataagcact gctgccactc agcagagaat tctgggccgg aggtgcacac aaaggcgcag    720

atcctggagc tgctggtgct ggagcagttc ctggccatcc tcccagaaaa gctgcagccc    780

tgggtgcaga ggcatcatcc agaaaatgga gaggaagctc tgactatgct ggaggatgtg    840

cagagagcgc ttgatggacc aaagcagatc ttcttttttg gacgaaggag ggacacggtt    900

gcagagaagc tagcaccttc agaaatcact gagcaattgc caactagcca gcgcacgccc    960

gtgaagaagc agctccagcg agaatcatgg gagctgcagt ccttaagacc acatgatgaa   1020

gacatcaaaa ctataaatgt gaaatccgct tcaaggcaaa agacttcttc aggcatagaa   1080

ctgcattgcg atgtttcgaa catcctcggt ataaatgcct cccagagttc cacatataga   1140

ggaatgtatg aacaagatga ttcaaaatat gaacatagga ttgcagagtc ccaaaagaat   1200

atgtacttca agactaggct gaagtgtccc aggtcactgt caggaggcag ataa         1254


<210>  5214
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  5214

Met Arg Arg Ser Gly Val Tyr Asn Ser Leu Leu Cys Gln Trp Phe Leu 
1               5                   10                  15      


Val Leu Val Phe Ala Asp Asp Thr Arg Gly Val Gln Lys Ala Glu Asn 
            20                  25                  30          


Ser Thr Trp Ile Met Gln Glu Leu Lys Glu Lys Leu Lys Lys Gly Gly 
        35                  40                  45              


Ala Ser Thr Gly Pro Gly Lys Leu Gly Ala Thr Asp Tyr Arg Ser Lys 
    50                  55                  60                  


Thr Gln Arg Met Tyr Gln Thr Leu Val Ser Phe Val Pro Thr Pro Ser 
65                  70                  75                  80  


Tyr His Pro Leu Ile Ala Val Ser Val Leu Asn Asn Lys Lys Gln Ser 
                85                  90                  95      


Ile Ser Ala Ile Gln Asn Asn Met Gln Val Leu Asp Thr Ser Pro Gln 
            100                 105                 110         


Thr Ala Ala Leu Leu Met Pro Leu Ala Asp Asn His Ile Cys Pro Cys 
        115                 120                 125             


Ala Asn Pro Leu Ser Trp Arg Val Arg Arg Ala Val Lys Asn Leu Trp 
    130                 135                 140                 


Glu Glu Val Asp Leu Glu Lys Gln Ala Thr Met Gly Gly Leu His Gly 
145                 150                 155                 160 


Leu Arg Pro Leu Leu Asn Ile Cys Pro Val Val Glu Thr Asp Leu Thr 
                165                 170                 175     


Gln Pro Ser Val Val Ser Glu Gln Val Lys Gln Leu Gln Gly Ser Gln 
            180                 185                 190         


Asn Asp Arg His Lys Val Arg Gln Glu Val Leu Thr Ile Phe Thr Pro 
        195                 200                 205             


Lys Pro Gly Ile Ser His Leu Ser Val Leu Ser Leu Asp Lys His Cys 
    210                 215                 220                 


Cys His Ser Ala Glu Asn Ser Gly Pro Glu Val His Thr Lys Ala Gln 
225                 230                 235                 240 


Ile Leu Glu Leu Leu Val Leu Glu Gln Phe Leu Ala Ile Leu Pro Glu 
                245                 250                 255     


Lys Leu Gln Pro Trp Val Gln Arg His His Pro Glu Asn Gly Glu Glu 
            260                 265                 270         


Ala Leu Thr Met Leu Glu Asp Val Gln Arg Ala Leu Asp Gly Pro Lys 
        275                 280                 285             


Gln Ile Phe Phe Phe Gly Arg Arg Arg Asp Thr Val Ala Glu Lys Leu 
    290                 295                 300                 


Ala Pro Ser Glu Ile Thr Glu Gln Leu Pro Thr Ser Gln Arg Thr Pro 
305                 310                 315                 320 


Val Lys Lys Gln Leu Gln Arg Glu Ser Trp Glu Leu Gln Ser Leu Arg 
                325                 330                 335     


Pro His Asp Glu Asp Ile Lys Thr Ile Asn Val Lys Ser Ala Ser Arg 
            340                 345                 350         


Gln Lys Thr Ser Ser Gly Ile Glu Leu His Cys Asp Val Ser Asn Ile 
        355                 360                 365             


Leu Gly Ile Asn Ala Ser Gln Ser Ser Thr Tyr Arg Gly Met Tyr Glu 
    370                 375                 380                 


Gln Asp Asp Ser Lys Tyr Glu His Arg Ile Ala Glu Ser Gln Lys Asn 
385                 390                 395                 400 


Met Tyr Phe Lys Thr Arg Leu Lys Cys Pro Arg Ser Leu Ser Gly Gly 
                405                 410                 415     


Arg 
    


<210>  5215
<211>  638
<212>  DNA
<213>  Homosapiens

<400>  5215
atgctgctgc tgccgccctc ctgcgaggcc gtggcgccac gtggctggag gaggagctgc     60

agctgccccg agtgctgccg cgtgtgcagc tctccagtgc ggctgcagcg ccaccgcgcg    120

ttgctttcga cgccggagtc cttcgcatgc gcagccagcg cccgggcctc aagtgcccca    180

ggacctggcg cagcccgcga gcccgcatca ggcttccagt gggccccgtg ggcagtgcca    240

gcctttccca cctccgcatc tggcaaagcc tggccttcgc tgcgcttcgg tgtcgccaca    300

tgccttctgg aaatatcaca cctccccacc tgcgcatgca gccgtctggc cctctgtggg    360

cctcggttcc cgcatgtgcc ccgtggaaag aacatacctt ccccaactat ctggcagcgt    420

ctggccttct ccgggcctcg gcctccccat ttgctgggtg gagaatcacg gcccggccac    480

atcggagcca atggctggtc tctggacctc ggtctccaca tttgctcagc cggcaggaac    540

atcccttctc ccgccctcta cctcggtggg tggccacggc cgagcaggca gcgacggccc    600

agtggaaaga ggacaaaccc ttgtgggcct tagggcga                            638


<210>  5216
<211>  210
<212>  PRT
<213>  Homosapiens

<400>  5216

Met Leu Leu Leu Pro Pro Ser Cys Glu Ala Val Ala Pro Arg Gly Trp 
1               5                   10                  15      


Arg Arg Ser Cys Ser Cys Pro Glu Cys Cys Arg Val Cys Ser Ser Pro 
            20                  25                  30          


Val Arg Leu Gln Arg His Arg Ala Leu Leu Ser Thr Pro Glu Ser Phe 
        35                  40                  45              


Ala Cys Ala Ala Ser Ala Arg Ala Ser Ser Ala Pro Gly Pro Gly Ala 
    50                  55                  60                  


Ala Arg Glu Pro Ala Ser Gly Phe Gln Trp Ala Pro Trp Ala Val Pro 
65                  70                  75                  80  


Ala Phe Pro Thr Ser Ala Ser Gly Lys Ala Trp Pro Ser Leu Arg Phe 
                85                  90                  95      


Gly Val Ala Thr Cys Leu Leu Glu Ile Ser His Leu Pro Thr Cys Ala 
            100                 105                 110         


Cys Ser Arg Leu Ala Leu Cys Gly Pro Arg Phe Pro His Val Pro Arg 
        115                 120                 125             


Gly Lys Asn Ile Pro Ser Pro Thr Ile Trp Gln Arg Leu Ala Phe Ser 
    130                 135                 140                 


Gly Pro Arg Pro Pro His Leu Leu Gly Gly Glu Ser Arg Pro Gly His 
145                 150                 155                 160 


Ile Gly Ala Asn Gly Trp Ser Leu Asp Leu Gly Leu His Ile Cys Ser 
                165                 170                 175     


Ala Gly Arg Asn Ile Pro Ser Pro Ala Leu Tyr Leu Gly Gly Trp Pro 
            180                 185                 190         


Arg Pro Ser Arg Gln Arg Arg Pro Ser Gly Lys Arg Thr Asn Pro Cys 
        195                 200                 205             


Gly Pro 
    210 


<210>  5217
<211>  638
<212>  DNA
<213>  Homosapiens

<400>  5217
atgctgctgc tgccgccctc ctgcgaggcc gtggcgccac gtggctggag gaggagctgc     60

agctgccccg agtgctgccg cgtgtgcagc tctccagtgc ggctgcagcg ccaccgcgcg    120

ttgctttcga cgccggagtc cttcgcatgc gcagccagcg cccgggcctc aagtgcccca    180

ggacctggcg cagcccgcga gcccgcatca ggcttccagt gggccccgtg ggcagtgcca    240

gcctttccca cctccgcatc tggcaaagcc tggccttcgc tgcgcttcgg tgtcgccaca    300

tgccttctgg aaatatcaca cctccccacc tgcgcatgca gccgtctggc cctctgtggg    360

cctcggttcc cgcatgtgcc ccgtggaaag aacatacctt ccccaactat ctggcagcgt    420

ctggccttct ccgggcctcg gcctccccat ttgctgggtg gagaatcacg gcccggccac    480

atcggagcca atggctggtc tctggacctc ggtctccaca tttgctcagc cggcaggaac    540

atcccttctc ccgccctcta cctcggtggg tggccacggc cgagcaggca gcgacggccc    600

agtggaaaga ggacaaaccc ttgtgggcct tagggcga                            638


<210>  5218
<211>  210
<212>  PRT
<213>  Homosapiens

<400>  5218

Met Leu Leu Leu Pro Pro Ser Cys Glu Ala Val Ala Pro Arg Gly Trp 
1               5                   10                  15      


Arg Arg Ser Cys Ser Cys Pro Glu Cys Cys Arg Val Cys Ser Ser Pro 
            20                  25                  30          


Val Arg Leu Gln Arg His Arg Ala Leu Leu Ser Thr Pro Glu Ser Phe 
        35                  40                  45              


Ala Cys Ala Ala Ser Ala Arg Ala Ser Ser Ala Pro Gly Pro Gly Ala 
    50                  55                  60                  


Ala Arg Glu Pro Ala Ser Gly Phe Gln Trp Ala Pro Trp Ala Val Pro 
65                  70                  75                  80  


Ala Phe Pro Thr Ser Ala Ser Gly Lys Ala Trp Pro Ser Leu Arg Phe 
                85                  90                  95      


Gly Val Ala Thr Cys Leu Leu Glu Ile Ser His Leu Pro Thr Cys Ala 
            100                 105                 110         


Cys Ser Arg Leu Ala Leu Cys Gly Pro Arg Phe Pro His Val Pro Arg 
        115                 120                 125             


Gly Lys Asn Ile Pro Ser Pro Thr Ile Trp Gln Arg Leu Ala Phe Ser 
    130                 135                 140                 


Gly Pro Arg Pro Pro His Leu Leu Gly Gly Glu Ser Arg Pro Gly His 
145                 150                 155                 160 


Ile Gly Ala Asn Gly Trp Ser Leu Asp Leu Gly Leu His Ile Cys Ser 
                165                 170                 175     


Ala Gly Arg Asn Ile Pro Ser Pro Ala Leu Tyr Leu Gly Gly Trp Pro 
            180                 185                 190         


Arg Pro Ser Arg Gln Arg Arg Pro Ser Gly Lys Arg Thr Asn Pro Cys 
        195                 200                 205             


Gly Pro 
    210 


<210>  5219
<211>  1863
<212>  DNA
<213>  Homosapiens

<400>  5219
atggagaata cagccctcgc tgactgggat gttgaaggac aggtttattc aaacacagaa     60

aaccctcaaa atctgagctg tccgcagaag cagctggagg ccaggggaga aactccagaa    120

ggagagacat ttgccatggc tgagcacttc aaacagatca ttagatgtcc tgtctgtcta    180

aaagatcttg aagaagccgt gcaactgaaa tgtggatatg cctgctgcct ccagtgcctc    240

aattcactcc agaaggagcc cgatggggaa ggtttactgt gccgtttctg ctctgtggtc    300

tctcagaagg atgacatcaa gcccaagtac aagctgaggg cgctggtttc catcatcaag    360

gaactagagc ccaagctgaa atctgttcta acaatgaacc caaggatgag gaagtttcaa    420

gtggatatga ccttcgatgt ggacacagcc aacaactatc tcatcatttc tgaagacctg    480

aggagtttcc gaagtgggga tttgagccag aataggaagg agcaagctga gaggttcgac    540

actgccctgt gcgtcctggg cacccctcgc ttcacttccg gccgccatta ctgggaggtg    600

gacgtgggca ccagccaagt gtgggatgtg ggcgtgtgca aggaatctgt caaccgacag    660

gggaagattg agctttcttc agaacacggc ttcttgactg tgggttgcag agaaggaaag    720

gtctttgctg ccagcactgt gcctatgact cctctctggg tgagtcccca gttgcacaga    780

gtggggattt tcctggatgt aggtatgagg tccattgcct tttacaatgt tagtgatggg    840

tgccatatca acacattcat cgagattcct gtttgcgagc cctggcgtcc attttttgct    900

cataaacgtg gaagtcaaga tgatcagagc atcctgagta tctgttctgt gatcaatcca    960

tccactgcca gtgccccagt ttcttctgag ggaaatacca gtgctttaca aagagtaggc   1020

gatgatgtct tcatgcagac agtggccatg gctgaacact ttaaacaagc aagcagttgt   1080

cctatctgcc tggattatct tgaaaacccc acgcacctga aatgtggata catctgttgc   1140

ctccgatgca tgaactcact gcgaaagggg cccgatggga agggggtgct gtgccctttc   1200

tgccctgtgg tctctcagaa aaatgacatc aggcccgctg cccagctggg ggcgctggtg   1260

tccaagatca aggaactaga gcccaaggtg agagctgttc tgcagatgaa tccaaggatg   1320

agaaagttcc aagtggatat gaccttggat gtggacacag ccaacaacga tctcatcgtt   1380

tctgaagacc tgaggcgtgt ccgatgtggg aatttcagac agaataggaa ggagcaagct   1440

gagaggttcg acactgccct gtgcgtcctg ggcacccctc gcttcacttc cggccgccat   1500

tactgggagg tgggcgtggg caccagccaa gtgtgggatg tgggcgtgtg caaggaatct   1560

gtgaaccgac aggggaacgt tgtactctct tcagaactcg gcttctggac tgtgggtttg   1620

agacaaggac agatctactt tgccagcact aagcctgtga cgggtctctg ggtgagctca   1680

ggtctacacc gagtggggat ttacctggat ataaaaacga gggccatttc cttctataat   1740

gtcagtgata ggtcacatat cttcacattc acgaaaattt ctgctactga gccactgcgc   1800

ccatgttttg ctcatgcaga tacaagtcgt gatgatcacg gatacttgag tgtgtgtgtg   1860

taa                                                                 1863


<210>  5220
<211>  620
<212>  PRT
<213>  Homosapiens

<400>  5220

Met Glu Asn Thr Ala Leu Ala Asp Trp Asp Val Glu Gly Gln Val Tyr 
1               5                   10                  15      


Ser Asn Thr Glu Asn Pro Gln Asn Leu Ser Cys Pro Gln Lys Gln Leu 
            20                  25                  30          


Glu Ala Arg Gly Glu Thr Pro Glu Gly Glu Thr Phe Ala Met Ala Glu 
        35                  40                  45              


His Phe Lys Gln Ile Ile Arg Cys Pro Val Cys Leu Lys Asp Leu Glu 
    50                  55                  60                  


Glu Ala Val Gln Leu Lys Cys Gly Tyr Ala Cys Cys Leu Gln Cys Leu 
65                  70                  75                  80  


Asn Ser Leu Gln Lys Glu Pro Asp Gly Glu Gly Leu Leu Cys Arg Phe 
                85                  90                  95      


Cys Ser Val Val Ser Gln Lys Asp Asp Ile Lys Pro Lys Tyr Lys Leu 
            100                 105                 110         


Arg Ala Leu Val Ser Ile Ile Lys Glu Leu Glu Pro Lys Leu Lys Ser 
        115                 120                 125             


Val Leu Thr Met Asn Pro Arg Met Arg Lys Phe Gln Val Asp Met Thr 
    130                 135                 140                 


Phe Asp Val Asp Thr Ala Asn Asn Tyr Leu Ile Ile Ser Glu Asp Leu 
145                 150                 155                 160 


Arg Ser Phe Arg Ser Gly Asp Leu Ser Gln Asn Arg Lys Glu Gln Ala 
                165                 170                 175     


Glu Arg Phe Asp Thr Ala Leu Cys Val Leu Gly Thr Pro Arg Phe Thr 
            180                 185                 190         


Ser Gly Arg His Tyr Trp Glu Val Asp Val Gly Thr Ser Gln Val Trp 
        195                 200                 205             


Asp Val Gly Val Cys Lys Glu Ser Val Asn Arg Gln Gly Lys Ile Glu 
    210                 215                 220                 


Leu Ser Ser Glu His Gly Phe Leu Thr Val Gly Cys Arg Glu Gly Lys 
225                 230                 235                 240 


Val Phe Ala Ala Ser Thr Val Pro Met Thr Pro Leu Trp Val Ser Pro 
                245                 250                 255     


Gln Leu His Arg Val Gly Ile Phe Leu Asp Val Gly Met Arg Ser Ile 
            260                 265                 270         


Ala Phe Tyr Asn Val Ser Asp Gly Cys His Ile Asn Thr Phe Ile Glu 
        275                 280                 285             


Ile Pro Val Cys Glu Pro Trp Arg Pro Phe Phe Ala His Lys Arg Gly 
    290                 295                 300                 


Ser Gln Asp Asp Gln Ser Ile Leu Ser Ile Cys Ser Val Ile Asn Pro 
305                 310                 315                 320 


Ser Thr Ala Ser Ala Pro Val Ser Ser Glu Gly Asn Thr Ser Ala Leu 
                325                 330                 335     


Gln Arg Val Gly Asp Asp Val Phe Met Gln Thr Val Ala Met Ala Glu 
            340                 345                 350         


His Phe Lys Gln Ala Ser Ser Cys Pro Ile Cys Leu Asp Tyr Leu Glu 
        355                 360                 365             


Asn Pro Thr His Leu Lys Cys Gly Tyr Ile Cys Cys Leu Arg Cys Met 
    370                 375                 380                 


Asn Ser Leu Arg Lys Gly Pro Asp Gly Lys Gly Val Leu Cys Pro Phe 
385                 390                 395                 400 


Cys Pro Val Val Ser Gln Lys Asn Asp Ile Arg Pro Ala Ala Gln Leu 
                405                 410                 415     


Gly Ala Leu Val Ser Lys Ile Lys Glu Leu Glu Pro Lys Val Arg Ala 
            420                 425                 430         


Val Leu Gln Met Asn Pro Arg Met Arg Lys Phe Gln Val Asp Met Thr 
        435                 440                 445             


Leu Asp Val Asp Thr Ala Asn Asn Asp Leu Ile Val Ser Glu Asp Leu 
    450                 455                 460                 


Arg Arg Val Arg Cys Gly Asn Phe Arg Gln Asn Arg Lys Glu Gln Ala 
465                 470                 475                 480 


Glu Arg Phe Asp Thr Ala Leu Cys Val Leu Gly Thr Pro Arg Phe Thr 
                485                 490                 495     


Ser Gly Arg His Tyr Trp Glu Val Gly Val Gly Thr Ser Gln Val Trp 
            500                 505                 510         


Asp Val Gly Val Cys Lys Glu Ser Val Asn Arg Gln Gly Asn Val Val 
        515                 520                 525             


Leu Ser Ser Glu Leu Gly Phe Trp Thr Val Gly Leu Arg Gln Gly Gln 
    530                 535                 540                 


Ile Tyr Phe Ala Ser Thr Lys Pro Val Thr Gly Leu Trp Val Ser Ser 
545                 550                 555                 560 


Gly Leu His Arg Val Gly Ile Tyr Leu Asp Ile Lys Thr Arg Ala Ile 
                565                 570                 575     


Ser Phe Tyr Asn Val Ser Asp Arg Ser His Ile Phe Thr Phe Thr Lys 
            580                 585                 590         


Ile Ser Ala Thr Glu Pro Leu Arg Pro Cys Phe Ala His Ala Asp Thr 
        595                 600                 605             


Ser Arg Asp Asp His Gly Tyr Leu Ser Val Cys Val 
    610                 615                 620 


<210>  5221
<211>  1932
<212>  DNA
<213>  Homosapiens

<400>  5221
atggcaatga aggcggaaac ctcggacatt acaccgcagc ctcggacatt acaccgcagc     60

ctcggacatt acaccgcagc ctcggacatt acaccgcagc ctcggacatt acaccgcagc    120

cacggacatt acaccgcagc ctcggacatt acaccgcagc ctcggacatt acaccgcagc    180

cacggacatt acaccgcagc ctcggtaaat tacaccgcag ccacggacat tacaccgcag    240

ccacggacat tacaccgcag cctcggacat tacaccgcag ccacggacat tacaccgcag    300

cctcgtaaat tacaccgcag cctcgtaaat tacaccgcag cctcggacat tacaccgcag    360

cctcggacat tacaccgcag ccacggacat tacaccgcag ccacggacat tacaccgcag    420

cctcggacat tacaccgcag ccacggacat tacaccgcag cctcccacgg acattacacc    480

gcagcctcgg acattacacc gcagccacgg acattacacc gcagcctcgt aaattacacc    540

gcagcctcgg acattacacc gcagccacgg acattacacc gcagccacgg acattacacc    600

gcagcctcgg acattacacc gcagcctcgg acattacacc gcagcctcgg acattacacc    660

gcagccacgg acattacacc gcagcctcgt aaattacacc gcagccacgg acattacacc    720

gcagcctcgg acattacacc gcagccacgg acattacacc gcagcctcgg acattacacc    780

gcagccacgg acattacacc gcagcctcgt aaattacacc gcagcctcgt aaattacacc    840

gcagcctcgg acattacacc gcagcctcgg aaattacacc gcagcctcgg gaattacacc    900

gcagcctcgg aaattacacc gcagcctcgg gaagtacacc gcagcctcgg aaagtacacc    960

gcagcctcgg gaagtacacc gcagccacgg acattacacc gcagccacgg acattacacc   1020

gcagcctcgg acattacacc gcagcctcgg acattacacc gcagcctcgt aaattacacc   1080

gcagccacgg aaattacacc gcagccacgg acattacacc gcagccacgg acattacacc   1140

gcagccacgg acattacacc gcagccacgg acattacacc gcagcctcgg aaattacacc   1200

gcagcctcgg aaattacacc gcagccacgg aaattacacc gcagccacgg acattacacc   1260

gcagccacgg acattacacc gcagccacgg acattacacc gcagcctcgg aaattacacc   1320

gcagcctcgg aaattacacc gcagcctcgg aaattacacc gcagccacgg acattacacc   1380

gcagccacgg acattacacc gcagcctcgg aaattacacc gcagcctcgg aaattacacc   1440

gcagccacgg aaattacacc gcagccacgg aaattacacc gcagccacgg aaattacacc   1500

gcagccacgg aaattacacc gcagcctcgg aaattacacc gcagccacgg aaattacacc   1560

gcagctacgg taattacacc gcagccacgg aaattacacc gcagtctcgg aaattccacc   1620

gcagctacgg aaatcacacc gcagtctcgg aaatcacacc gcagtctcgg aaatcacacc   1680

gcagtctcgg aaattacacc gcagctacgg aaattacacc gcagtctcgg aaattacacc   1740

gcggctacgg aaattacacc gcggctacgg aaattacacc gccggccacg gaaattacac   1800

cgcggccacg gaaattacac cgcagtctcg gaaattacac cgcagcttcg gaaattacac   1860

cgcagctttg gaaattacac cgcagctttg gaaattacac cgcagctaca gaaattacat   1920

ttttactttt aa                                                       1932


<210>  5222
<211>  643
<212>  PRT
<213>  Homosapiens

<400>  5222

Met Ala Met Lys Ala Glu Thr Ser Asp Ile Thr Pro Gln Pro Arg Thr 
1               5                   10                  15      


Leu His Arg Ser Leu Gly His Tyr Thr Ala Ala Ser Asp Ile Thr Pro 
            20                  25                  30          


Gln Pro Arg Thr Leu His Arg Ser His Gly His Tyr Thr Ala Ala Ser 
        35                  40                  45              


Asp Ile Thr Pro Gln Pro Arg Thr Leu His Arg Ser His Gly His Tyr 
    50                  55                  60                  


Thr Ala Ala Ser Val Asn Tyr Thr Ala Ala Thr Asp Ile Thr Pro Gln 
65                  70                  75                  80  


Pro Arg Thr Leu His Arg Ser Leu Gly His Tyr Thr Ala Ala Thr Asp 
                85                  90                  95      


Ile Thr Pro Gln Pro Arg Lys Leu His Arg Ser Leu Val Asn Tyr Thr 
            100                 105                 110         


Ala Ala Ser Asp Ile Thr Pro Gln Pro Arg Thr Leu His Arg Ser His 
        115                 120                 125             


Gly His Tyr Thr Ala Ala Thr Asp Ile Thr Pro Gln Pro Arg Thr Leu 
    130                 135                 140                 


His Arg Ser His Gly His Tyr Thr Ala Ala Ser His Gly His Tyr Thr 
145                 150                 155                 160 


Ala Ala Ser Asp Ile Thr Pro Gln Pro Arg Thr Leu His Arg Ser Leu 
                165                 170                 175     


Val Asn Tyr Thr Ala Ala Ser Asp Ile Thr Pro Gln Pro Arg Thr Leu 
            180                 185                 190         


His Arg Ser His Gly His Tyr Thr Ala Ala Ser Asp Ile Thr Pro Gln 
        195                 200                 205             


Pro Arg Thr Leu His Arg Ser Leu Gly His Tyr Thr Ala Ala Thr Asp 
    210                 215                 220                 


Ile Thr Pro Gln Pro Arg Lys Leu His Arg Ser His Gly His Tyr Thr 
225                 230                 235                 240 


Ala Ala Ser Asp Ile Thr Pro Gln Pro Arg Thr Leu His Arg Ser Leu 
                245                 250                 255     


Gly His Tyr Thr Ala Ala Thr Asp Ile Thr Pro Gln Pro Arg Lys Leu 
            260                 265                 270         


His Arg Ser Leu Val Asn Tyr Thr Ala Ala Ser Asp Ile Thr Pro Gln 
        275                 280                 285             


Pro Arg Lys Leu His Arg Ser Leu Gly Asn Tyr Thr Ala Ala Ser Glu 
    290                 295                 300                 


Ile Thr Pro Gln Pro Arg Glu Val His Arg Ser Leu Gly Lys Tyr Thr 
305                 310                 315                 320 


Ala Ala Ser Gly Ser Thr Pro Gln Pro Arg Thr Leu His Arg Ser His 
                325                 330                 335     


Gly His Tyr Thr Ala Ala Ser Asp Ile Thr Pro Gln Pro Arg Thr Leu 
            340                 345                 350         


His Arg Ser Leu Val Asn Tyr Thr Ala Ala Thr Glu Ile Thr Pro Gln 
        355                 360                 365             


Pro Arg Thr Leu His Arg Ser His Gly His Tyr Thr Ala Ala Thr Asp 
    370                 375                 380                 


Ile Thr Pro Gln Pro Arg Thr Leu His Arg Ser Leu Gly Asn Tyr Thr 
385                 390                 395                 400 


Ala Ala Ser Glu Ile Thr Pro Gln Pro Arg Lys Leu His Arg Ser His 
                405                 410                 415     


Gly His Tyr Thr Ala Ala Thr Asp Ile Thr Pro Gln Pro Arg Thr Leu 
            420                 425                 430         


His Arg Ser Leu Gly Asn Tyr Thr Ala Ala Ser Glu Ile Thr Pro Gln 
        435                 440                 445             


Pro Arg Lys Leu His Arg Ser His Gly His Tyr Thr Ala Ala Thr Asp 
    450                 455                 460                 


Ile Thr Pro Gln Pro Arg Lys Leu His Arg Ser Leu Gly Asn Tyr Thr 
465                 470                 475                 480 


Ala Ala Thr Glu Ile Thr Pro Gln Pro Arg Lys Leu His Arg Ser His 
                485                 490                 495     


Gly Asn Tyr Thr Ala Ala Thr Glu Ile Thr Pro Gln Pro Arg Lys Leu 
            500                 505                 510         


His Arg Ser His Gly Asn Tyr Thr Ala Ala Thr Val Ile Thr Pro Gln 
        515                 520                 525             


Pro Arg Lys Leu His Arg Ser Leu Gly Asn Ser Thr Ala Ala Thr Glu 
    530                 535                 540                 


Ile Thr Pro Gln Ser Arg Lys Ser His Arg Ser Leu Gly Asn His Thr 
545                 550                 555                 560 


Ala Val Ser Glu Ile Thr Pro Gln Leu Arg Lys Leu His Arg Ser Leu 
                565                 570                 575     


Gly Asn Tyr Thr Ala Ala Thr Glu Ile Thr Pro Arg Leu Arg Lys Leu 
            580                 585                 590         


His Arg Arg Pro Arg Lys Leu His Arg Gly His Gly Asn Tyr Thr Ala 
        595                 600                 605             


Val Ser Glu Ile Thr Pro Gln Leu Arg Lys Leu His Arg Ser Phe Gly 
    610                 615                 620                 


Asn Tyr Thr Ala Ala Leu Glu Ile Thr Pro Gln Leu Gln Lys Leu His 
625                 630                 635                 640 


Phe Tyr Phe 
            


<210>  5223
<211>  282
<212>  DNA
<213>  Homosapiens

<400>  5223
atgaagctgt ttctggttct cattattctg ctgtttgagg tactcacaga cggggcaaga     60

ctcaaaaaat gcttcaataa agtaacaggc tattgcagga agaaatgcaa ggtaggagaa    120

agatatgaaa taggatgtct aagtgggaaa ttatgttgtg ctaatgatga agaagagaaa    180

aaacatgtgt catttaagaa gccacatcaa cattctggtg agaagctgag tgtgctgcag    240

gattacatca tcttacccac catcaccatt ttcacagtct aa                       282


<210>  5224
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  5224

Met Lys Leu Phe Leu Val Leu Ile Ile Leu Leu Phe Glu Val Leu Thr 
1               5                   10                  15      


Asp Gly Ala Arg Leu Lys Lys Cys Phe Asn Lys Val Thr Gly Tyr Cys 
            20                  25                  30          


Arg Lys Lys Cys Lys Val Gly Glu Arg Tyr Glu Ile Gly Cys Leu Ser 
        35                  40                  45              


Gly Lys Leu Cys Cys Ala Asn Asp Glu Glu Glu Lys Lys His Val Ser 
    50                  55                  60                  


Phe Lys Lys Pro His Gln His Ser Gly Glu Lys Leu Ser Val Leu Gln 
65                  70                  75                  80  


Asp Tyr Ile Ile Leu Pro Thr Ile Thr Ile Phe Thr Val 
                85                  90              


<210>  5225
<211>  630
<212>  DNA
<213>  Homosapiens

<400>  5225
atgcatgaat tgggcaactc caaaccagaa gtggttcggg gtcttcactt aagaagtggg     60

ccagtgctgc gactgtgcac ttgtgcaact cttaacccag ccacatttct tccagacaat    120

aaagaaaaga tagaacataa ctgtcagcaa gtaattgttc aaacctacgc tgctcaaggg    180

gatcctttag aggttccctt gactgatcct gacctcacct tatgtactga tggaagttcc    240

tttgtagaaa aaggacttcg aaaagtgggg tatgcagtgg tcagtgataa tggaatactt    300

gaaagttaca tgaacttaca agcacgaagc acaaagttca tcgtagaagc cctgtcagtg    360

agagttacct tctctcttgc taggaagaag gcatattacg gggcaagact caaaaaatgc    420

ttcaataaag taacaggcta ttgcaggaag aaatgcaagg taggagaaag atatgaaata    480

ggatgtctaa gtgggaaatt atgttgtgct aatgatgaag aagagaaaaa acatgtgtca    540

tttaagaagc cacatcaaca ttctggtgag aagctgagtg tgctgcagga ttacatcatc    600

ttacccacca tcaccatttt cacagtctaa                                     630


<210>  5226
<211>  209
<212>  PRT
<213>  Homosapiens

<400>  5226

Met His Glu Leu Gly Asn Ser Lys Pro Glu Val Val Arg Gly Leu His 
1               5                   10                  15      


Leu Arg Ser Gly Pro Val Leu Arg Leu Cys Thr Cys Ala Thr Leu Asn 
            20                  25                  30          


Pro Ala Thr Phe Leu Pro Asp Asn Lys Glu Lys Ile Glu His Asn Cys 
        35                  40                  45              


Gln Gln Val Ile Val Gln Thr Tyr Ala Ala Gln Gly Asp Pro Leu Glu 
    50                  55                  60                  


Val Pro Leu Thr Asp Pro Asp Leu Thr Leu Cys Thr Asp Gly Ser Ser 
65                  70                  75                  80  


Phe Val Glu Lys Gly Leu Arg Lys Val Gly Tyr Ala Val Val Ser Asp 
                85                  90                  95      


Asn Gly Ile Leu Glu Ser Tyr Met Asn Leu Gln Ala Arg Ser Thr Lys 
            100                 105                 110         


Phe Ile Val Glu Ala Leu Ser Val Arg Val Thr Phe Ser Leu Ala Arg 
        115                 120                 125             


Lys Lys Ala Tyr Tyr Gly Ala Arg Leu Lys Lys Cys Phe Asn Lys Val 
    130                 135                 140                 


Thr Gly Tyr Cys Arg Lys Lys Cys Lys Val Gly Glu Arg Tyr Glu Ile 
145                 150                 155                 160 


Gly Cys Leu Ser Gly Lys Leu Cys Cys Ala Asn Asp Glu Glu Glu Lys 
                165                 170                 175     


Lys His Val Ser Phe Lys Lys Pro His Gln His Ser Gly Glu Lys Leu 
            180                 185                 190         


Ser Val Leu Gln Asp Tyr Ile Ile Leu Pro Thr Ile Thr Ile Phe Thr 
        195                 200                 205             


Val 
    


<210>  5227
<211>  1802
<212>  DNA
<213>  Homosapiens

<400>  5227
atgttaaacg ggcccaccct gggagctgta gtggtcactg tggagctgag cactgggctg     60

cactcctcgc tgccccagag tgaccagaaa gagttggccg ttcactaccc tggagtgtgg    120

acctctgggc gaggaacctg tatccgtagc gctgccttgc acgtccaggc tcacagaggc    180

aacctcccgt cactcaacag gtggctgagg gacccccgca ccagggcagc acctgctgga    240

cttgggttca ccagcgaacg agcaggtctg atgctcctct cagggtctaa ggcctgcttc    300

tctctcggcg gcagggcgga gatgcacggt acctactttg aggctgagga ttcaatctct    360

gaccacacaa cgcacagtcc agtccgcatc atgcctgaca cacagcaagc actccataaa    420

cacgactacc gttattcatt tacaattaag gaagaaagag gtgaaggggc acatgccaag    480

gacaagcccg cctcagccct ggacatcgtt catcgcgcga ggatctcagg tgccaggtgg    540

gcaaatgcta ctgtcgctca acgagaggaa tcccagagaa ggagaagccc ctgtcaacct    600

tttattggga gtggaacaca tgaggttcag ctcgtgccgg gcactgtaca ttcactgaag    660

cagctcaagg ggctcagccc cgacactgac gccacactga gcaggatgca cggcccgggg    720

ctcacactgt ccatggagga ggtggggtca gcccgaggtg ggcggatggt ggcccgagac    780

accgagagct tggttctggg actgtggctc agctgacccg tggcacagct gcacctaaga    840

catggccctg gctaggcggg aacagctcac agtagcgata cattcacagg acacagttgg    900

tgtccagaaa agggggctca gaacacagtt tctacacaag cacttggcac ccacacgaca    960

gagacgtcac tcaagcagca cagccacaaa tagtttacag cagctcatgc ccggcatccg   1020

cccatgctgg gagactccct gaaaggtggg cacctgccgt ctatgaggag gtgtctccct   1080

ccatcattaa ccccaaacca cacaatgtgt gaggagagca ggcctctggg tgaactcaca   1140

cattcatacc caaggaagag gcaaacacac tcaagtccag agttcccagt ggtgccgccc   1200

agacctactg tcccgggggt gttatggctg tccctcggct tccccagagc agccaggaca   1260

gcctgcaccg cctcccagac tcttgcagga aggggagctc tgccctgggg aggaaactga   1320

caggctggga gacaagactc ccatcgcagg gacatgcaca gcagcagcca cagccccgcg   1380

gacggggcat ggggatggga caggcaggga gccacactgc cccctcagtg tgtgcctgtg   1440

gttctgtcct ggtcctgccc acttggagcc caggcagaca ggtggcattg agcagggccc   1500

aggtccagac agccctctgg ccagatgtga ctggaagagg ctgatgccag ggcagcacca   1560

ggccttctgc aagtcccaga gccagtgtgc agaaagtgcc agcacggcct gtgctgtggc   1620

tcctcaggat gaagtcacgt ccaggacagg agggtttatg cagacacaca gacactgctg   1680

acggggacag ggatggctcg gccactatga ggctggactc ttctgtctgt tcagggagtc   1740

gatgtaatga aaaatggccc ccagagccca gctggtctca acattgtcaa ttttccgagt   1800

ga                                                                  1802


<210>  5228
<211>  271
<212>  PRT
<213>  Homosapiens

<400>  5228

Met Leu Asn Gly Pro Thr Leu Gly Ala Val Val Val Thr Val Glu Leu 
1               5                   10                  15      


Ser Thr Gly Leu His Ser Ser Leu Pro Gln Ser Asp Gln Lys Glu Leu 
            20                  25                  30          


Ala Val His Tyr Pro Gly Val Trp Thr Ser Gly Arg Gly Thr Cys Ile 
        35                  40                  45              


Arg Ser Ala Ala Leu His Val Gln Ala His Arg Gly Asn Leu Pro Ser 
    50                  55                  60                  


Leu Asn Arg Trp Leu Arg Asp Pro Arg Thr Arg Ala Ala Pro Ala Gly 
65                  70                  75                  80  


Leu Gly Phe Thr Ser Glu Arg Ala Gly Leu Met Leu Leu Ser Gly Ser 
                85                  90                  95      


Lys Ala Cys Phe Ser Leu Gly Gly Arg Ala Glu Met His Gly Thr Tyr 
            100                 105                 110         


Phe Glu Ala Glu Asp Ser Ile Ser Asp His Thr Thr His Ser Pro Val 
        115                 120                 125             


Arg Ile Met Pro Asp Thr Gln Gln Ala Leu His Lys His Asp Tyr Arg 
    130                 135                 140                 


Tyr Ser Phe Thr Ile Lys Glu Glu Arg Gly Glu Gly Ala His Ala Lys 
145                 150                 155                 160 


Asp Lys Pro Ala Ser Ala Leu Asp Ile Val His Arg Ala Arg Ile Ser 
                165                 170                 175     


Gly Ala Arg Trp Ala Asn Ala Thr Val Ala Gln Arg Glu Glu Ser Gln 
            180                 185                 190         


Arg Arg Arg Ser Pro Cys Gln Pro Phe Ile Gly Ser Gly Thr His Glu 
        195                 200                 205             


Val Gln Leu Val Pro Gly Thr Val His Ser Leu Lys Gln Leu Lys Gly 
    210                 215                 220                 


Leu Ser Pro Asp Thr Asp Ala Thr Leu Ser Arg Met His Gly Pro Gly 
225                 230                 235                 240 


Leu Thr Leu Ser Met Glu Glu Val Gly Ser Ala Arg Gly Gly Arg Met 
                245                 250                 255     


Val Ala Arg Asp Thr Glu Ser Leu Val Leu Gly Leu Trp Leu Ser 
            260                 265                 270     


<210>  5229
<211>  1802
<212>  DNA
<213>  Homosapiens

<400>  5229
atgttaaacg ggcccaccct gggagctgta gtggtcactg tggagctgag cactgggctg     60

cactcctcgc tgccccagag tgaccagaaa gagttggccg ttcactaccc tggagtgtgg    120

acctctgggc gaggaacctg tatccgtagc gctgccttgc acgtccaggc tcacagaggc    180

aacctcccgt cactcaacag gtggctgagg gacccccgca ccagggcagc acctgctgga    240

cttgggttca ccagcgaacg agcaggtctg atgctcctct cagggtctaa ggcctgcttc    300

tctctcggcg gcagggcgga gatgcacggt acctactttg aggctgagga ttcaatctct    360

gaccacacaa cgcacagtcc agtccgcatc atgcctgaca cacagcaagc actccataaa    420

cacgactacc gttattcatt tacaattaag gaagaaagag gtgaaggggc acatgccaag    480

gacaagcccg cctcagccct ggacatcgtt catcgcgcga ggatctcagg tgccaggtgg    540

gcaaatgcta ctgtcgctca acgagaggaa tcccagagaa ggagaagccc ctgtcaacct    600

tttattggga gtggaacaca tgaggttcag ctcgtgccgg gcactgtaca ttcactgaag    660

cagctcaagg ggctcagccc cgacactgac gccacactga gcaggatgca cggcccgggg    720

ctcacactgt ccatggagga ggtggggtca gcccgaggtg ggcggatggt ggcccgagac    780

accgagagct tggttctggg actgtggctc agctgacccg tggcacagct gcacctaaga    840

catggccctg gctaggcggg aacagctcac agtagcgata cattcacagg acacagttgg    900

tgtccagaaa agggggctca gaacacagtt tctacacaag cacttggcac ccacacgaca    960

gagacgtcac tcaagcagca cagccacaaa tagtttacag cagctcatgc ccggcatccg   1020

cccatgctgg gagactccct gaaaggtggg cacctgccgt ctatgaggag gtgtctccct   1080

ccatcattaa ccccaaacca cacaatgtgt gaggagagca ggcctctggg tgaactcaca   1140

cattcatacc caaggaagag gcaaacacac tcaagtccag agttcccagt ggtgccgccc   1200

agacctactg tcccgggggt gttatggctg tccctcggct tccccagagc agccaggaca   1260

gcctgcaccg cctcccagac tctcgcagga aggggagctc tgccctgggg aggaaactga   1320

caggctggga gacaagactc ccatcgcagg gacatgcaca gcagcagcca cagccccgcg   1380

gacggggcat ggggatggga caggcaggga gccacactgc cccctcagtg tgtgcctgtg   1440

gttctgtcct ggtcctgccc acttggagcc caggcagaca ggtggcattg agcagggccc   1500

aggtccagac agccctctgg ccagatgtga ctggaagagg ctgatgccag ggcagcacca   1560

ggccttctgc aagtcccaga gccagtgtgc agaaagtgcc agcacggcct gtgctgtggc   1620

tcctcaggat gaagtcacgt ccaggacagg agggtttatg cagacacaca gacactgctg   1680

acggggacag ggatggctcg gccactatga ggctggactc ttctgtctgt tcagggagtc   1740

gatgtaatga aaaatggccc ccagagccca gctggtctca acattgtcaa ttttccgagt   1800

ga                                                                  1802


<210>  5230
<211>  271
<212>  PRT
<213>  Homosapiens

<400>  5230

Met Leu Asn Gly Pro Thr Leu Gly Ala Val Val Val Thr Val Glu Leu 
1               5                   10                  15      


Ser Thr Gly Leu His Ser Ser Leu Pro Gln Ser Asp Gln Lys Glu Leu 
            20                  25                  30          


Ala Val His Tyr Pro Gly Val Trp Thr Ser Gly Arg Gly Thr Cys Ile 
        35                  40                  45              


Arg Ser Ala Ala Leu His Val Gln Ala His Arg Gly Asn Leu Pro Ser 
    50                  55                  60                  


Leu Asn Arg Trp Leu Arg Asp Pro Arg Thr Arg Ala Ala Pro Ala Gly 
65                  70                  75                  80  


Leu Gly Phe Thr Ser Glu Arg Ala Gly Leu Met Leu Leu Ser Gly Ser 
                85                  90                  95      


Lys Ala Cys Phe Ser Leu Gly Gly Arg Ala Glu Met His Gly Thr Tyr 
            100                 105                 110         


Phe Glu Ala Glu Asp Ser Ile Ser Asp His Thr Thr His Ser Pro Val 
        115                 120                 125             


Arg Ile Met Pro Asp Thr Gln Gln Ala Leu His Lys His Asp Tyr Arg 
    130                 135                 140                 


Tyr Ser Phe Thr Ile Lys Glu Glu Arg Gly Glu Gly Ala His Ala Lys 
145                 150                 155                 160 


Asp Lys Pro Ala Ser Ala Leu Asp Ile Val His Arg Ala Arg Ile Ser 
                165                 170                 175     


Gly Ala Arg Trp Ala Asn Ala Thr Val Ala Gln Arg Glu Glu Ser Gln 
            180                 185                 190         


Arg Arg Arg Ser Pro Cys Gln Pro Phe Ile Gly Ser Gly Thr His Glu 
        195                 200                 205             


Val Gln Leu Val Pro Gly Thr Val His Ser Leu Lys Gln Leu Lys Gly 
    210                 215                 220                 


Leu Ser Pro Asp Thr Asp Ala Thr Leu Ser Arg Met His Gly Pro Gly 
225                 230                 235                 240 


Leu Thr Leu Ser Met Glu Glu Val Gly Ser Ala Arg Gly Gly Arg Met 
                245                 250                 255     


Val Ala Arg Asp Thr Glu Ser Leu Val Leu Gly Leu Trp Leu Ser 
            260                 265                 270     


<210>  5231
<211>  1242
<212>  DNA
<213>  Homosapiens

<400>  5231
atggttgctg ttactcccac tccaataacc gaggaagccc taccaacctg tggaccctgg     60

ctgtggccga gtccccctcc acctccggcc aaaagacccc cgtggcagct cgctaggccg    120

ctggcccgtc cccacccgag gagcggcgac cctggcacaa gaggacctgg gttgctcggc    180

gcccctgtga aatccgggct gttcaccgcc cgagccgcca ctacacgcaa ccgggaacgg    240

agactgagtg gcggcccaga cccggggcgc tcggcaagcc gcagccccac cgcccacttc    300

aaggcgcggc ctgggtctcc gcccctcccc agaacgcgga gacgccgggc ctggaggagc    360

gcgcgctacg gccccagcag cgccctcacg tcccaggcct tcccggccct tcttcctgcg    420

ccggaagggc gcgctgcaga gagggacccg caggagcgca gctcaccggg gcggctgagg    480

gcgaaccgag gcggtgaggt caccgatggt ggaccacgca tctcacggct cgctgacgcc    540

cagggatctg gaacgctctg cgccgcccgg gactacacta cccagaatcc tcagcgcggc    600

cgggactacg ctacccagca tcctcggcgc ggcccggagg ctatgcgacc ctgcgcgtcg    660

catcccctcg gtggactaca ctccccagag tcctcgggag tcgtccagga ttacgctgct    720

ctcaagtgca tacatgatga tctttttgtc caagcatcag aggtgatccc agcatcttca    780

cagtaccagc ctttccccaa gatcctcgcc agagaaaagg gttacccaga tcatcctgcc    840

actgtagggg acctccaagt tggtcaccct ggagaggaac ccagcaaatc tggggcagca    900

gcaggccttt ctcatgtgac tttattacag cggctggggc gtccctgtga gaggcctgac    960

ccaggtgtgg ggggcgcagc cagaccgggg tgctcctggg gtgcagagga ttcgtggcag   1020

cacggagagt ccgagggaaa ggttccagca tttggaggca aacatgaagc tccatcctct   1080

ccaattctgg ggcaaccgtg tggagatgat caaaatgctt caccttcaaa actttcaaag   1140

gaagagttaa tacagagtat ggatcgtgta gatcgagaaa ttgcaaaagt agaacagcag   1200

atccttaaac tgaaaaagaa acaagtaaaa gtctttgcct aa                      1242


<210>  5232
<211>  413
<212>  PRT
<213>  Homosapiens

<400>  5232

Met Val Ala Val Thr Pro Thr Pro Ile Thr Glu Glu Ala Leu Pro Thr 
1               5                   10                  15      


Cys Gly Pro Trp Leu Trp Pro Ser Pro Pro Pro Pro Pro Ala Lys Arg 
            20                  25                  30          


Pro Pro Trp Gln Leu Ala Arg Pro Leu Ala Arg Pro His Pro Arg Ser 
        35                  40                  45              


Gly Asp Pro Gly Thr Arg Gly Pro Gly Leu Leu Gly Ala Pro Val Lys 
    50                  55                  60                  


Ser Gly Leu Phe Thr Ala Arg Ala Ala Thr Thr Arg Asn Arg Glu Arg 
65                  70                  75                  80  


Arg Leu Ser Gly Gly Pro Asp Pro Gly Arg Ser Ala Ser Arg Ser Pro 
                85                  90                  95      


Thr Ala His Phe Lys Ala Arg Pro Gly Ser Pro Pro Leu Pro Arg Thr 
            100                 105                 110         


Arg Arg Arg Arg Ala Trp Arg Ser Ala Arg Tyr Gly Pro Ser Ser Ala 
        115                 120                 125             


Leu Thr Ser Gln Ala Phe Pro Ala Leu Leu Pro Ala Pro Glu Gly Arg 
    130                 135                 140                 


Ala Ala Glu Arg Asp Pro Gln Glu Arg Ser Ser Pro Gly Arg Leu Arg 
145                 150                 155                 160 


Ala Asn Arg Gly Gly Glu Val Thr Asp Gly Gly Pro Arg Ile Ser Arg 
                165                 170                 175     


Leu Ala Asp Ala Gln Gly Ser Gly Thr Leu Cys Ala Ala Arg Asp Tyr 
            180                 185                 190         


Thr Thr Gln Asn Pro Gln Arg Gly Arg Asp Tyr Ala Thr Gln His Pro 
        195                 200                 205             


Arg Arg Gly Pro Glu Ala Met Arg Pro Cys Ala Ser His Pro Leu Gly 
    210                 215                 220                 


Gly Leu His Ser Pro Glu Ser Ser Gly Val Val Gln Asp Tyr Ala Ala 
225                 230                 235                 240 


Leu Lys Cys Ile His Asp Asp Leu Phe Val Gln Ala Ser Glu Val Ile 
                245                 250                 255     


Pro Ala Ser Ser Gln Tyr Gln Pro Phe Pro Lys Ile Leu Ala Arg Glu 
            260                 265                 270         


Lys Gly Tyr Pro Asp His Pro Ala Thr Val Gly Asp Leu Gln Val Gly 
        275                 280                 285             


His Pro Gly Glu Glu Pro Ser Lys Ser Gly Ala Ala Ala Gly Leu Ser 
    290                 295                 300                 


His Val Thr Leu Leu Gln Arg Leu Gly Arg Pro Cys Glu Arg Pro Asp 
305                 310                 315                 320 


Pro Gly Val Gly Gly Ala Ala Arg Pro Gly Cys Ser Trp Gly Ala Glu 
                325                 330                 335     


Asp Ser Trp Gln His Gly Glu Ser Glu Gly Lys Val Pro Ala Phe Gly 
            340                 345                 350         


Gly Lys His Glu Ala Pro Ser Ser Pro Ile Leu Gly Gln Pro Cys Gly 
        355                 360                 365             


Asp Asp Gln Asn Ala Ser Pro Ser Lys Leu Ser Lys Glu Glu Leu Ile 
    370                 375                 380                 


Gln Ser Met Asp Arg Val Asp Arg Glu Ile Ala Lys Val Glu Gln Gln 
385                 390                 395                 400 


Ile Leu Lys Leu Lys Lys Lys Gln Val Lys Val Phe Ala 
                405                 410             


<210>  5233
<211>  994
<212>  DNA
<213>  Homosapiens

<400>  5233
ggagccctcc ttggcagtgc ttgggtgtcg gggctctgag gctccggcct gacctcttca     60

cggggtcgac gggatcgtct ccggatgcca ggagtcccaa agggccgacc aggatgagga    120

aaccccaggc ggagtccggg ggaagcagca cggcatccca gcctcaggcc tgcccggacg    180

gtgatggttg gggtaagatt ggggaagatg ccaggtgata gaatccaccc tgcctctgac    240

agcatccaat ctggagcaaa ggcttctttc aaccttcccc caagctccca atacaagccc    300

aaattctgga acaagtcctt tccaacacct ccttcagaga agctccctgg ctccaggcag    360

tgcttgctcc cctcactgca gcaggaagcc taacttgcga actgcaggtg tgctccaggt    420

ggtcactgga tgcaagaaat ggtgcgagaa ctttggatgt ggaacgtgga ggaggaggaa    480

cacgaagtgg ggatctgcac ttggggtggt cagcactgcg gatgcccagc aaagtcactg    540

cctggtccac atcccggagg ggtctctgcg cctcagtcgg catcgcagct gatggtgaaa    600

cttttggtgt ggcagaagag tgtccacaaa cttcggaaga acagaaacgc ctacagttgc    660

ggccccctgt agtgcaattt gtgtcagtct agggagagtg gatttggagc ccaaccacca    720

ttgaggaaaa tccatctgac ggacatgagc ctcactcagg ttctcatcta cttccttggg    780

gtctgccccg cctccctcag aagtttggaa ccacatactg ttctggaggg gacctctcac    840

tgctgcagaa cctgtcctcc aggataccga caagtgttca tctcggtcgt ggctaattaa    900

cttaccatat ggtagtgaac tcccttctgg ggccccaata ttttgtttat ttttaaaaaa    960

taaaattagt accattgttt attttctgaa tgta                                994


<210>  5234
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  5234

Met Gln Glu Met Val Arg Glu Leu Trp Met Trp Asn Val Glu Glu Glu 
1               5                   10                  15      


Glu His Glu Val Gly Ile Cys Thr Trp Gly Gly Gln His Cys Gly Cys 
            20                  25                  30          


Pro Ala Lys Ser Leu Pro Gly Pro His Pro Gly Gly Val Ser Ala Pro 
        35                  40                  45              


Gln Ser Ala Ser Gln Leu Met Val Lys Leu Leu Val Trp Gln Lys Ser 
    50                  55                  60                  


Val His Lys Leu Arg Lys Asn Arg Asn Ala Tyr Ser Cys Gly Pro Leu 
65                  70                  75                  80  


<210>  5235
<211>  901
<212>  DNA
<213>  Homosapiens

<400>  5235
caaagcggga gccttccgcg gcagagcttg ggtgtccggg ctctgaggct ccggtctgac     60

ctctccacgg ggtcgacggg aatgtctccg gatgccagga gttgcaaagg gcagacctag    120

atgaggaaac cccaggcaga gtcctgggga agcagcacgg catccgagcc tcaggcttgc    180

ctggacggtg ttggttgggg taagattggg gaagatgcca ggtgatagaa tccaccctgc    240

ctctgacagc atccaatctg gagcaaaggc ttatttcaac cctcccccaa gctcccaata    300

caagcccaaa ttctggaaca ggtcctttcc aacacctcct tcagagaagc tccctggctc    360

caggcagtgc ttgctcccct cactgcagca ggaagcctaa cttgcgaact gcaggtgtgc    420

tccaggtggt cactggatgc aaggcattga cagatggatc ccatcgatac ccccactgca    480

aaaccatagt gcagtgaata gaagacactt ctctgcaccc caaaagctcc atgctgattg    540

tgagaaggaa atgctggatg gaggggttcc tggaactact gtgagggttt cttttgattt    600

ctcctgctta gaaatggtgc gagaactttg gatgtggaac gtggaggagg aggaacacga    660

agtggggatc tgcacttggg gtggtcagca ctgcggatgc ccagcaaagt cactgcctgg    720

tccacatccc ggaggggtct ctgcgcctca gtcggcatcg cagctgatgg tgaaactttt    780

ggtgtggcag aagagtgtcc acaaacttcg gaagatcgct gctcagagtg atgaatggag    840

ttgtgttttg aataaaatat ctatgcatcc ttttgtgagc aaggagcatg atggtactta    900

g                                                                    901


<210>  5236
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  5236

Met Gln Gly Ile Asp Arg Trp Ile Pro Ser Ile Pro Pro Leu Gln Asn 
1               5                   10                  15      


His Ser Ala Val Asn Arg Arg His Phe Ser Ala Pro Gln Lys Leu His 
            20                  25                  30          


Ala Asp Cys Glu Lys Glu Met Leu Asp Gly Gly Val Pro Gly Thr Thr 
        35                  40                  45              


Val Arg Val Ser Phe Asp Phe Ser Cys Leu Glu Met Val Arg Glu Leu 
    50                  55                  60                  


Trp Met Trp Asn Val Glu Glu Glu Glu His Glu Val Gly Ile Cys Thr 
65                  70                  75                  80  


Trp Gly Gly Gln His Cys Gly Cys Pro Ala Lys Ser Leu Pro Gly Pro 
                85                  90                  95      


His Pro Gly Gly Val Ser Ala Pro Gln Ser Ala Ser Gln Leu Met Val 
            100                 105                 110         


Lys Leu Leu Val Trp Gln Lys Ser Val His Lys Leu Arg Lys Ile Ala 
        115                 120                 125             


Ala Gln Ser Asp Glu Trp Ser Cys Val Leu Asn Lys Ile Ser Met His 
    130                 135                 140                 


Pro Phe Val Ser Lys Glu His Asp Gly Thr 
145                 150                 


<210>  5237
<211>  341
<212>  DNA
<213>  Homosapiens

<400>  5237
atggtgcgag aactttggat gtggaacgtg gaggaggagg aacacgaagt ggggatctgc     60

acttggggtg gtcagcactg cggatgccca gcaaagtcac tgcctggtcc acatcccgga    120

ggggtctctg cgcctcagtc ggcatcgcag ctgatggtga aacttttggt gtggcagaag    180

agtgtccaca aacttcggaa gttgctagag aaaactgaaa actactagtt ttgaaagcct    240

cacttctgcc aatggaagca cattccagca tgtcgccaac gcaatccact ttccaccact    300

ttcacaaaaa acgttactgc acaattatac tatcctaccc t                        341


<210>  5238
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  5238

Met Val Arg Glu Leu Trp Met Trp Asn Val Glu Glu Glu Glu His Glu 
1               5                   10                  15      


Val Gly Ile Cys Thr Trp Gly Gly Gln His Cys Gly Cys Pro Ala Lys 
            20                  25                  30          


Ser Leu Pro Gly Pro His Pro Gly Gly Val Ser Ala Pro Gln Ser Ala 
        35                  40                  45              


Ser Gln Leu Met Val Lys Leu Leu Val Trp Gln Lys Ser Val His Lys 
    50                  55                  60                  


Leu Arg Lys Leu Leu Glu Lys Thr Glu Asn Tyr 
65                  70                  75  


<210>  5239
<211>  639
<212>  DNA
<213>  Homosapiens

<400>  5239
atggtgcgag aactttggat gtggaacgtg gaggaggagg aacacgaagt ggggatctgc     60

acttggggtg gtcagcactg cggatgccca gcaaagtcac tgcctggtcc acatcccgga    120

ggggtctctg cgcctcagtc ggcatcgcag ctgatggtga aacttttggt gtggcagaag    180

agtgtccaca aacttcggaa gggccgcggc ggcaaggtcc ttgctcccat ggcgtgactc    240

cagggtgcag gagcctgggc tgagcaggtg gagtagggtg agctccgcca agaacccagc    300

gagagtggcg ccccagggcg gcacaggagg ccgcatttaa catgtcaatc atctgaaaga    360

ttttatggca tctttttttt gacatcttat aatatctata atgtttatta tatcttgtga    420

tataattatt aacaccactt cagtgtgatt attatgatta tttttatacc aacacatctt    480

caattattaa tattcccagt tgctagagaa aactgaaaac tactagtttt gaaagcctca    540

cttctgccaa tggaagcaca ttccagcatg tcgccaacgc aatccacttt ccaccacttt    600

cacaaaaaac gttactgcac aattatacta tcctaccct                           639


<210>  5240
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  5240

Met Val Arg Glu Leu Trp Met Trp Asn Val Glu Glu Glu Glu His Glu 
1               5                   10                  15      


Val Gly Ile Cys Thr Trp Gly Gly Gln His Cys Gly Cys Pro Ala Lys 
            20                  25                  30          


Ser Leu Pro Gly Pro His Pro Gly Gly Val Ser Ala Pro Gln Ser Ala 
        35                  40                  45              


Ser Gln Leu Met Val Lys Leu Leu Val Trp Gln Lys Ser Val His Lys 
    50                  55                  60                  


Leu Arg Lys Gly Arg Gly Gly Lys Val Leu Ala Pro Met Ala 
65                  70                  75              


<210>  5241
<211>  622
<212>  DNA
<213>  Homosapiens

<400>  5241
atgatggcac aggttccagc ctccagcatg tggcagtgcc tcttccttct agttctccag     60

cccagcagaa gctcctgctg cccgccgccc tcctactgct ctatcgccac caccaaccgt    120

agcgagttgc tggctgcccg atgtagagga ctaggaatca ggagtcagtg gccgtatgct    180

ggaggctgga gccgagggag cgtggctccc ctcgctgtgg ttgttggcag caacggagag    240

atagcagcgc ggctggaacg cattcatcaa caacttttga aacatatacg aaaattatct    300

aaaaatcctc aaaataccaa ttcagaagga acatctacag gaacacctga cgaggctgca    360

cccttggcag gaagaacacc tgacacggct gaaagcttgg tggaaaaaac acctgatgag    420

gctgcaccct tagtggaggg aacatctgac aaaattcaat gtctggggaa agcaacatct    480

ggaaagtttg aacagtcagc agaagaatat gttaggccat gtgtctctat aacagctatt    540

gaactctgca ttgtacagtg aaagcagtca tagataatgt gtgagcaaat aggcatgatt    600

gcactccaat aaaactttgt at                                             622


<210>  5242
<211>  186
<212>  PRT
<213>  Homosapiens

<400>  5242

Met Met Ala Gln Val Pro Ala Ser Ser Met Trp Gln Cys Leu Phe Leu 
1               5                   10                  15      


Leu Val Leu Gln Pro Ser Arg Ser Ser Cys Cys Pro Pro Pro Ser Tyr 
            20                  25                  30          


Cys Ser Ile Ala Thr Thr Asn Arg Ser Glu Leu Leu Ala Ala Arg Cys 
        35                  40                  45              


Arg Gly Leu Gly Ile Arg Ser Gln Trp Pro Tyr Ala Gly Gly Trp Ser 
    50                  55                  60                  


Arg Gly Ser Val Ala Pro Leu Ala Val Val Val Gly Ser Asn Gly Glu 
65                  70                  75                  80  


Ile Ala Ala Arg Leu Glu Arg Ile His Gln Gln Leu Leu Lys His Ile 
                85                  90                  95      


Arg Lys Leu Ser Lys Asn Pro Gln Asn Thr Asn Ser Glu Gly Thr Ser 
            100                 105                 110         


Thr Gly Thr Pro Asp Glu Ala Ala Pro Leu Ala Gly Arg Thr Pro Asp 
        115                 120                 125             


Thr Ala Glu Ser Leu Val Glu Lys Thr Pro Asp Glu Ala Ala Pro Leu 
    130                 135                 140                 


Val Glu Gly Thr Ser Asp Lys Ile Gln Cys Leu Gly Lys Ala Thr Ser 
145                 150                 155                 160 


Gly Lys Phe Glu Gln Ser Ala Glu Glu Tyr Val Arg Pro Cys Val Ser 
                165                 170                 175     


Ile Thr Ala Ile Glu Leu Cys Ile Val Gln 
            180                 185     


<210>  5243
<211>  847
<212>  DNA
<213>  Homosapiens

<400>  5243
ttcctgtgct cctacttccc tctcttctgt caccttgtga agaaggtgcc tgcttcctct     60

tcaccttccg ccatgattgt cagcttcctg aggccacccc agacatgcag agctgtctga    120

agtctcagtg ggctcaacca gctcccctgt tcaacatccg gcaaggtcca aacgaaggtg    180

acaatcaaca gggatcttat tgggaagctc tggtaaaaat ggtgtcagaa gtgggatctg    240

aagtagagcc ttaacaatct ccaggactgc tgagtgaaca agcaaggtac ctgcaaggac    300

ctacttttgt cccttgatct ctcaaagtgg ctggggatca tggatggata catgtgacca    360

agcattgcaa gttaaagata tttctgaatc ttggacctct tatttacagt gaagccccct    420

catgcatagt aaagcagaga ggaatgtaaa aggttgctgc atcgataatc aatttctggt    480

gagcaataat tataggtaat gtaaaatggg acaattattg cttttcatca tatcttgaaa    540

gaactcttac agtccatgat tttgaaaaaa aaaatctaag ttcactcttt ttttttctat    600

taaaaaaaga cattatcctg tagaagttca agagtaaaat ctgaaggcag cttatctgac    660

ctggccacat ggtcttgcca cttgttaaat ataactttct acacactaac ttctccagac    720

ctcagatctt caactctcta aaatggaaac ctagtagtat ttgtctctag acctgcagct    780

gaactgagca ttttagggaa ggaacaaaca tacacacgat atatatatag tcagattatg    840

aacccag                                                              847


<210>  5244
<211>  49
<212>  PRT
<213>  Homosapiens

<400>  5244

Met Gln Ser Cys Leu Lys Ser Gln Trp Ala Gln Pro Ala Pro Leu Phe 
1               5                   10                  15      


Asn Ile Arg Gln Gly Pro Asn Glu Gly Asp Asn Gln Gln Gly Ser Tyr 
            20                  25                  30          


Trp Glu Ala Leu Val Lys Met Val Ser Glu Val Gly Ser Glu Val Glu 
        35                  40                  45              


Pro 
    


<210>  5245
<211>  1071
<212>  DNA
<213>  Homosapiens

<400>  5245
agggccctag tcctccagag cagtttatgg ctgtcaaatt atctgattcc agaatcgccc     60

tgaaatctgg ctatggaaaa tatcttggta taaattcaga tgaacttgtt gggcattcag    120

atgcaattgg accaagagaa caatgggaac cagtctttca aaatgggaaa atggctttgt    180

tggcctcaaa tagctgcttt attagatgca atgaagcagg ggacatagaa gcaaaaagta    240

aaacagcagg agaagaagaa atgatcaaga ttagatcctg tgctgaaaaa gaaaccaaga    300

aaaaagatga cattccagaa gaagacaaag gaaatgtaaa acaatgtgaa atcaattatg    360

taaagaaatt tcagagcttc caagaccaca aacttaaaat aagtaaagaa gagagtaaaa    420

ttcttaaaaa ggctcagaaa gatggatttt tgcatgagac gcttctggac agagaaccaa    480

attgaaagcc gacagatact gcaaatgact ggaatttttg tttctgcctt atctttttgt    540

gttttttttt tctgaataaa atattcagag gaaatgcttt tacagagttc ttgagttgtt    600

gtgaaattat tgtttagcta gtagctagtt taaccaggat taaacaagtt taatcaggat    660

tcttcatgga tgtacttcct tggctaacta cagtttttca catggaaatg aaacttacag    720

tacacactta acgtatcaca gaattttttt ctggatttcc tgtcctgaag catgaagtgt    780

actagaaacc aattcttcct gcgctacttg tggaatcttt cttactggat cataatctta    840

ctttacttta tacaatagat gcttaatcag tgcctttaat aggaagttgg aaactccaaa    900

tccaatcaac aaggctttga ttctgcctcc taagtactac ccagatcaca gacaatccaa    960

atatcagaac taggggtctg ggcagagagg acaaatcatc tattagggag tgggacagaa   1020

agtggaaaca ttacaaagga gcaagtaggc tcagaacaga ggggagagta g            1071


<210>  5246
<211>  152
<212>  PRT
<213>  Homosapiens

<400>  5246

Met Ala Val Lys Leu Ser Asp Ser Arg Ile Ala Leu Lys Ser Gly Tyr 
1               5                   10                  15      


Gly Lys Tyr Leu Gly Ile Asn Ser Asp Glu Leu Val Gly His Ser Asp 
            20                  25                  30          


Ala Ile Gly Pro Arg Glu Gln Trp Glu Pro Val Phe Gln Asn Gly Lys 
        35                  40                  45              


Met Ala Leu Leu Ala Ser Asn Ser Cys Phe Ile Arg Cys Asn Glu Ala 
    50                  55                  60                  


Gly Asp Ile Glu Ala Lys Ser Lys Thr Ala Gly Glu Glu Glu Met Ile 
65                  70                  75                  80  


Lys Ile Arg Ser Cys Ala Glu Lys Glu Thr Lys Lys Lys Asp Asp Ile 
                85                  90                  95      


Pro Glu Glu Asp Lys Gly Asn Val Lys Gln Cys Glu Ile Asn Tyr Val 
            100                 105                 110         


Lys Lys Phe Gln Ser Phe Gln Asp His Lys Leu Lys Ile Ser Lys Glu 
        115                 120                 125             


Glu Ser Lys Ile Leu Lys Lys Ala Gln Lys Asp Gly Phe Leu His Glu 
    130                 135                 140                 


Thr Leu Leu Asp Arg Glu Pro Asn 
145                 150         


<210>  5247
<211>  6528
<212>  DNA
<213>  Homosapiens

<400>  5247
cggccgcccg cctccccgga cgagccgtcg gtggccgcgt cgtcggtggg cagcagccgc     60

ttgccgctca gcgcctcgct tgccttctcc gacctcaccg aggagatgct ggactgcggg    120

cccagcggct tggtgcggga gctggaggag ctgcgctcgg agaacgacta tctcaaggac    180

gagattgagg agctgcgggc cgagatgctg gagatgcggg acgtctatat ggaggaggac    240

gtgtatcagc tgcaggagct gcgacagcag ctggaccagg ccagcaagac ctgccgcatc    300

ctgcagtacc ggctgcgcaa agccgagcgc cgcagtctcc gtgccgccca gaccggccag    360

gtggacggcg agcttatccg tggtctggag caggatgtca aggtctctaa ggacatctcc    420

atgcggctgc ataaggagct cgaggtggtg gagaagaaac gggcgcggct ggaggaggag    480

aacgaagagc ttcgtcagcg gctcatcgag actgagctgg ctaagcaggt gctgcagacg    540

gagctggagc gaccgagaga gcattccttg aagaaaagag gaacccgctc cctggggaag    600

gccgataaga agactttggt gcaggaggac agtgcagacc tgaagtgcca gttgcacttt    660

gcaaaggagg agtcagccct catgtgcaag aagctcacta agcttgccaa ggagaatgac    720

agcatgaagg aggagctgct gaagtaccgc tcgctctatg gggacctgga cagcgcgctg    780

tcagccgagg agctggccga tgccccccac tcgcgggaga ccgagctgaa ggtgcacctg    840

aagctggtgg aggaggaagc caacctgctg agccgccgca tcgtggagct ggaggtggag    900

aaccgaggcc tgcgggctga gatggacgac atgaaggatc atggaggtgg ctgtgggggt    960

cctgaggcac gcctggcctt ctccgcgctg ggtggcggag agtgcgggga gagcttggca   1020

gagctgcggc gacacctgca gtttgtcgaa gaggaggccg agctgctgcg gcgctcctct   1080

gccgagctcg aggaccagaa caagctgctg ctgaacgagc tggccaagtt ccgctcggag   1140

cacgagctgg acgtggcgct gtcggaggac agttgttctg tgctcagcga accttcacag   1200

gaggagctgg cggccgccaa gctgcagatc ggcgagctca gcggcaaggt caagaagctg   1260

cagtacgaga accgcgtgct cctctccaac ctccagcgct gtgacctcgc ctcctgccag   1320

agtacgcggc ccatgctgga gacggacgcc gaggccgggg actctgccca gtgtgtgcct   1380

gctcccctgg gcgagacaca cgagtcccat gcggtccgac tctgcagagc cagggaggcc   1440

gaggtgctgc ctgggctgag agagcaggcc gccctggtca gtaaggccat cgatgtcctg   1500

gtggctgatg ccaatggctt cacggctggc ctccggctgt gtctggacaa cgagtgtgct   1560

gacttccggc tgcatgaggc ccccgacaac agcgagggcc ccagggacac caagctcatc   1620

catgccatcc tggtgcgcct gagcgtgctg cagcaggagc tgaatgcctt cacgcggaag   1680

gcagatgcag tcctcgggtg ctctgtcaag gaacagcagg agtccttctc atcactgccc   1740

cccttgggct cccaggggct ctctaaggag attcttctgg caaaagacct tggctcagac   1800

tttcagccac ctgacttcag ggacctgccg gaatgggagc ccaggatccg agaggctttc   1860

cgcactggtg acttggactc taagcccgac cccagccgga gcttcaggcc ttaccgagct   1920

gaagacaatg attcctatgc ctctgagatc aaggagctgc agctggtgct ggctgaggcc   1980

cacgacagcc tccggggctt gcaagagcag ctctcccagg agcggcagct acgaaaggag   2040

gaggccgaca atttcaacca gaaaatggtc cagctgaagg aggaccagca gagggcgctc   2100

ctgaggcggg agtttgagct gcagagtctg agcctccagc ggaggctgga gcagaaattc   2160

tggagccagg agaagaacat gctggtgcag gagtcccagc aattcaagca caacttcctg   2220

ctgctcttca tgaagctcag gtggttcctc aagcgctggc ggcagggcaa ggttttgccc   2280

agcgaagggg atgacttcct cgaggtgaac agcatgaagg agctgtactt gctgatggag   2340

gaagaggaga taaacgctca gcattctgat aacaaggcct gcacggggga cagctggacc   2400

cagaacacgc ccaatgagta catcaagaca ctggccgaca tgaaggtgac gctgaaggag   2460

ctgtgctggc tgctccggga tgaacgccgt ggtctgacgg agcttcagca acagtttgcc   2520

aaggccaagg ctacctggga gacagagcgg gcagagctca agggccatac ctcccagatg   2580

gagctgaaga cagggaaggg ggccggggag cgggcagggc ccgactggaa ggcagcccta   2640

cagcgggagc gtgaggagca gcagcacctc ctagctgagt cctacagcgc tgtcatggag   2700

ctgactcggc agctgcagat cagtgagcgc aactggagcc aggaaaagct gcagctggtg   2760

gagcggctgc agggtgagaa gcagcaggtg gagcagcagg tgaaggagct gcagaaccgc   2820

ctaagccagc tgcagaaggc tgccgacccc tgggtcctga agcactcgga gctggagaag   2880

caggacaaca gctggaagga gacacgcagt gagaagatcc acgacaagga ggctgtttcc   2940

gaagttgagc ttggaggaaa tggtttaaag agaaccaaat ctgtttcttc catgtctgag   3000

tttgaaagtt tgctcgactg ttccccttac cttgctggcg gagatgcccg gggcaagaag   3060

ctgcctaaca accctgcctt tggctttgtg agctccgagc caggggatcc agagaaagac   3120

accaaggaga agcctgggct ctcgtcgagg gactgcaacc acctgggtgc cctggcctgc   3180

caggaccccc cagggaggca gatgcagcgc agctacacgg ctcctgacaa gacgggcatc   3240

cgagtctact atagtccccc ggtggcccgg cgcctcggag tccctgtggt tcatgacaaa   3300

gagggcaaga tcattatcga gcccggcttc ctcttcacca cagccaagcc caaagagtcg   3360

gccgaggctg atgggctggc tgagagctcc tatggtcggt ggctctgcaa cttctcacgg   3420

cagcgcctgg acggaggctc agcgggcagc ccctcggcgg ccgggcctgg cttcccagcg   3480

gccctgcatg actttgagat gtcaggcaac atgagtgatg acatgaagga gatcaccaac   3540

tgtgtgcgcc aggccatgcg ctccggctca ctggagagga aagtgaagag cacatccagc   3600

cagacggtgg gcctggccag tgtgggcaca cagaccatcc gcacggtcag cgtgggcctg   3660

cagaccgacc caccccgcag cagcctccat ggcaaggcct ggtcaccccg cagctcttcg   3720

ctcgtgtctg tgcgcagcaa gcagatctcc tcctccctgg acaaggtcca ttcgcgcatc   3780

gagcggccct gctgctcccc caagtatggc tcaccaaagc tccagaggcg gtctgtgtcc   3840

aagctggaca gcagcaagga ccgcagcctg tggaacctgc accagggcaa gcagaacggc   3900

tcggcctggg cccgctccac caccacgcgg gacagccctg tattgagaaa catcaacgat   3960

ggactctcca gcctcttcag tgtggtggag cactcaggga gcacggagtc tgtctggaaa   4020

ctaggcatgt ctgagacgcg ggccaagccc gagcctccca agtacggcat tgtgcaggaa   4080

ttcttccgta atgtgtgtgg ccgggcaccg agccccacct catcagcagg agaggagggc   4140

accaagaagc cagagcccct ctccccagcc agctaccatc agccagaggg tgtggccagg   4200

atcctgaaca agaaggcagc caagttgggc agcagtgagg aggtcagact caccatgctc   4260

ccccaggtgg ggaaggatgg tgtcctccgg gacggagatg gagccgtggt ccttcccaat   4320

gaggacgctg tttgtgactg tagtacccag tctctcacct cctgcttcgc ccgatcgtcc   4380

cgctctgcca tccgccactc tccttccaag tgcaggctgc acccttcaga gtccagctgg   4440

ggtggggagg agagggcact cccccccagc gagtgacaga gcagccaagc tccccgcctc   4500

aaccagccca gcccctggat agcagaaggg aaccagcaga gacgagacga ggctgaacac   4560

cagggtcatg ccagtcccgc cagccgcctc ctccatgccc cagtgactgg tgtgggcaga   4620

gcaggcagcc agtggagctg tgggccagtt ccgctcttgg atgctgctgc tctcacccat   4680

gaggtcaggg gggccctcca aggttatctc caggtgaggg gattcacatc aggccacaag   4740

ccaccagagg ccttctgcca cctcccagag cgacagccag ggaggctgcg tactcagcct   4800

cggggagaaa tccccgtggg acctgagccc caagacctac ggaccactca gccttaccat   4860

cgtaccgtcc aggattgtcc ttgccatctt tgttgtctca gccagacctt ggttttcagt   4920

aaagccccag tttctacttc ctgcatgcca ctgtgcaagg ccactcatca ctgttcctgc   4980

agaagcctct ggacgtgggg ctggatgggg ttgaaaatgt tacatgtaaa tattggtttg   5040

gttcggtttt tagcatttta cttggtaact ggttgttttc ttttttgggg tggggggatt   5100

ggtttgtaaa aattctctac tcttttggaa tgtgatttct aagtttgttg gtttcttcaa   5160

atgcctttta agtcttggta acattcccaa agcagaaaac tgcctgaccc acagtgggga   5220

ttccctggag aattggggtc ccaagaagga atgctgccct tctcgaaccc gttctccccc   5280

ttcctcctgc ctctctgcct tttactgcta ttcccttctt ctcctccttt atccttcttt   5340

ctgttttccc catctccact ctctcttcaa ccaaagtccc aaggaaccct cggggctcaa   5400

tcccccatag accacttggc ttgggtccat ggggttggca tcagttggtt ggcggaaatg   5460

ggggaccagt tggcatgatg gccctaaact gggaaacctc atgtttctta tgtctcacct   5520

ctttccagag ccaaatcagc cccttttgga atgatgactt cattggaatg caaatcaagt   5580

cattttggtg catcagtggc tcttaggcct gcacacacga gacatcagaa tccaatcctc   5640

tgaccctgtg ccagcccttt cccccagttt atttcccacc aaaggctgac ctctaagagg   5700

tcttgctttc tatgaactca agatgggtcc cacctctagg tgtccccagg tgcactcttc   5760

taccggttgg cttccgatgt gacaaggcca agggcccaaa gacttgaccc tcttacaccc   5820

ttgctgacat ggttccatca tgtccacccg catgcacttt tatggtttca tcacccagcc   5880

tcttctcctc tggcccaccc agcgtccagg ctctttctcc ctctcccctc ctatctagaa   5940

tgtcccctgc ttctagcctc accagacccc ccaagctccc actacttctt ccataataat   6000

agtaataaca atggttatca tcatcccctg cacatcccgc ctaaagcact ttactatata   6060

gaaaacgttt cccctggccg ggcatggtgg ctcacgcctg aaatcccagc tctttgggag   6120

gctgaggcga gcggatcagt tgaggtcagg agttcaacgc cagcctggcc aacgtggtga   6180

atccctgtct gtactaaaag tacaaaaaat tagctgagca tggtggtgcg tgcctgtaat   6240

cccagctact cgggaggctg aggtgggaga atcgcttgag cccaggaggc ggaggttgca   6300

ggagcagaga ttgcgccact gcactccagc ctggatgaca gagtgagacc caatctcaaa   6360

aaagaaatcg tttcccaccc cacatctcct tcagacctct cagggacaac tctgggaggc   6420

agccttggca ggacatgggt tagtgcgccc attttgctgt gaggaaactg aggtacaggt   6480

ctcatcccag agcatgagaa gtcactgagt ttagatgaga acttgggt                6528


<210>  5248
<211>  1456
<212>  PRT
<213>  Homosapiens

<400>  5248

Met Leu Asp Cys Gly Pro Ser Gly Leu Val Arg Glu Leu Glu Glu Leu 
1               5                   10                  15      


Arg Ser Glu Asn Asp Tyr Leu Lys Asp Glu Ile Glu Glu Leu Arg Ala 
            20                  25                  30          


Glu Met Leu Glu Met Arg Asp Val Tyr Met Glu Glu Asp Val Tyr Gln 
        35                  40                  45              


Leu Gln Glu Leu Arg Gln Gln Leu Asp Gln Ala Ser Lys Thr Cys Arg 
    50                  55                  60                  


Ile Leu Gln Tyr Arg Leu Arg Lys Ala Glu Arg Arg Ser Leu Arg Ala 
65                  70                  75                  80  


Ala Gln Thr Gly Gln Val Asp Gly Glu Leu Ile Arg Gly Leu Glu Gln 
                85                  90                  95      


Asp Val Lys Val Ser Lys Asp Ile Ser Met Arg Leu His Lys Glu Leu 
            100                 105                 110         


Glu Val Val Glu Lys Lys Arg Ala Arg Leu Glu Glu Glu Asn Glu Glu 
        115                 120                 125             


Leu Arg Gln Arg Leu Ile Glu Thr Glu Leu Ala Lys Gln Val Leu Gln 
    130                 135                 140                 


Thr Glu Leu Glu Arg Pro Arg Glu His Ser Leu Lys Lys Arg Gly Thr 
145                 150                 155                 160 


Arg Ser Leu Gly Lys Ala Asp Lys Lys Thr Leu Val Gln Glu Asp Ser 
                165                 170                 175     


Ala Asp Leu Lys Cys Gln Leu His Phe Ala Lys Glu Glu Ser Ala Leu 
            180                 185                 190         


Met Cys Lys Lys Leu Thr Lys Leu Ala Lys Glu Asn Asp Ser Met Lys 
        195                 200                 205             


Glu Glu Leu Leu Lys Tyr Arg Ser Leu Tyr Gly Asp Leu Asp Ser Ala 
    210                 215                 220                 


Leu Ser Ala Glu Glu Leu Ala Asp Ala Pro His Ser Arg Glu Thr Glu 
225                 230                 235                 240 


Leu Lys Val His Leu Lys Leu Val Glu Glu Glu Ala Asn Leu Leu Ser 
                245                 250                 255     


Arg Arg Ile Val Glu Leu Glu Val Glu Asn Arg Gly Leu Arg Ala Glu 
            260                 265                 270         


Met Asp Asp Met Lys Asp His Gly Gly Gly Cys Gly Gly Pro Glu Ala 
        275                 280                 285             


Arg Leu Ala Phe Ser Ala Leu Gly Gly Gly Glu Cys Gly Glu Ser Leu 
    290                 295                 300                 


Ala Glu Leu Arg Arg His Leu Gln Phe Val Glu Glu Glu Ala Glu Leu 
305                 310                 315                 320 


Leu Arg Arg Ser Ser Ala Glu Leu Glu Asp Gln Asn Lys Leu Leu Leu 
                325                 330                 335     


Asn Glu Leu Ala Lys Phe Arg Ser Glu His Glu Leu Asp Val Ala Leu 
            340                 345                 350         


Ser Glu Asp Ser Cys Ser Val Leu Ser Glu Pro Ser Gln Glu Glu Leu 
        355                 360                 365             


Ala Ala Ala Lys Leu Gln Ile Gly Glu Leu Ser Gly Lys Val Lys Lys 
    370                 375                 380                 


Leu Gln Tyr Glu Asn Arg Val Leu Leu Ser Asn Leu Gln Arg Cys Asp 
385                 390                 395                 400 


Leu Ala Ser Cys Gln Ser Thr Arg Pro Met Leu Glu Thr Asp Ala Glu 
                405                 410                 415     


Ala Gly Asp Ser Ala Gln Cys Val Pro Ala Pro Leu Gly Glu Thr His 
            420                 425                 430         


Glu Ser His Ala Val Arg Leu Cys Arg Ala Arg Glu Ala Glu Val Leu 
        435                 440                 445             


Pro Gly Leu Arg Glu Gln Ala Ala Leu Val Ser Lys Ala Ile Asp Val 
    450                 455                 460                 


Leu Val Ala Asp Ala Asn Gly Phe Thr Ala Gly Leu Arg Leu Cys Leu 
465                 470                 475                 480 


Asp Asn Glu Cys Ala Asp Phe Arg Leu His Glu Ala Pro Asp Asn Ser 
                485                 490                 495     


Glu Gly Pro Arg Asp Thr Lys Leu Ile His Ala Ile Leu Val Arg Leu 
            500                 505                 510         


Ser Val Leu Gln Gln Glu Leu Asn Ala Phe Thr Arg Lys Ala Asp Ala 
        515                 520                 525             


Val Leu Gly Cys Ser Val Lys Glu Gln Gln Glu Ser Phe Ser Ser Leu 
    530                 535                 540                 


Pro Pro Leu Gly Ser Gln Gly Leu Ser Lys Glu Ile Leu Leu Ala Lys 
545                 550                 555                 560 


Asp Leu Gly Ser Asp Phe Gln Pro Pro Asp Phe Arg Asp Leu Pro Glu 
                565                 570                 575     


Trp Glu Pro Arg Ile Arg Glu Ala Phe Arg Thr Gly Asp Leu Asp Ser 
            580                 585                 590         


Lys Pro Asp Pro Ser Arg Ser Phe Arg Pro Tyr Arg Ala Glu Asp Asn 
        595                 600                 605             


Asp Ser Tyr Ala Ser Glu Ile Lys Glu Leu Gln Leu Val Leu Ala Glu 
    610                 615                 620                 


Ala His Asp Ser Leu Arg Gly Leu Gln Glu Gln Leu Ser Gln Glu Arg 
625                 630                 635                 640 


Gln Leu Arg Lys Glu Glu Ala Asp Asn Phe Asn Gln Lys Met Val Gln 
                645                 650                 655     


Leu Lys Glu Asp Gln Gln Arg Ala Leu Leu Arg Arg Glu Phe Glu Leu 
            660                 665                 670         


Gln Ser Leu Ser Leu Gln Arg Arg Leu Glu Gln Lys Phe Trp Ser Gln 
        675                 680                 685             


Glu Lys Asn Met Leu Val Gln Glu Ser Gln Gln Phe Lys His Asn Phe 
    690                 695                 700                 


Leu Leu Leu Phe Met Lys Leu Arg Trp Phe Leu Lys Arg Trp Arg Gln 
705                 710                 715                 720 


Gly Lys Val Leu Pro Ser Glu Gly Asp Asp Phe Leu Glu Val Asn Ser 
                725                 730                 735     


Met Lys Glu Leu Tyr Leu Leu Met Glu Glu Glu Glu Ile Asn Ala Gln 
            740                 745                 750         


His Ser Asp Asn Lys Ala Cys Thr Gly Asp Ser Trp Thr Gln Asn Thr 
        755                 760                 765             


Pro Asn Glu Tyr Ile Lys Thr Leu Ala Asp Met Lys Val Thr Leu Lys 
    770                 775                 780                 


Glu Leu Cys Trp Leu Leu Arg Asp Glu Arg Arg Gly Leu Thr Glu Leu 
785                 790                 795                 800 


Gln Gln Gln Phe Ala Lys Ala Lys Ala Thr Trp Glu Thr Glu Arg Ala 
                805                 810                 815     


Glu Leu Lys Gly His Thr Ser Gln Met Glu Leu Lys Thr Gly Lys Gly 
            820                 825                 830         


Ala Gly Glu Arg Ala Gly Pro Asp Trp Lys Ala Ala Leu Gln Arg Glu 
        835                 840                 845             


Arg Glu Glu Gln Gln His Leu Leu Ala Glu Ser Tyr Ser Ala Val Met 
    850                 855                 860                 


Glu Leu Thr Arg Gln Leu Gln Ile Ser Glu Arg Asn Trp Ser Gln Glu 
865                 870                 875                 880 


Lys Leu Gln Leu Val Glu Arg Leu Gln Gly Glu Lys Gln Gln Val Glu 
                885                 890                 895     


Gln Gln Val Lys Glu Leu Gln Asn Arg Leu Ser Gln Leu Gln Lys Ala 
            900                 905                 910         


Ala Asp Pro Trp Val Leu Lys His Ser Glu Leu Glu Lys Gln Asp Asn 
        915                 920                 925             


Ser Trp Lys Glu Thr Arg Ser Glu Lys Ile His Asp Lys Glu Ala Val 
    930                 935                 940                 


Ser Glu Val Glu Leu Gly Gly Asn Gly Leu Lys Arg Thr Lys Ser Val 
945                 950                 955                 960 


Ser Ser Met Ser Glu Phe Glu Ser Leu Leu Asp Cys Ser Pro Tyr Leu 
                965                 970                 975     


Ala Gly Gly Asp Ala Arg Gly Lys Lys Leu Pro Asn Asn Pro Ala Phe 
            980                 985                 990         


Gly Phe Val Ser Ser Glu Pro Gly  Asp Pro Glu Lys Asp  Thr Lys Glu 
        995                 1000                 1005             


Lys Pro  Gly Leu Ser Ser Arg  Asp Cys Asn His Leu  Gly Ala Leu 
    1010                 1015                 1020             


Ala Cys  Gln Asp Pro Pro Gly  Arg Gln Met Gln Arg  Ser Tyr Thr 
    1025                 1030                 1035             


Ala Pro  Asp Lys Thr Gly Ile  Arg Val Tyr Tyr Ser  Pro Pro Val 
    1040                 1045                 1050             


Ala Arg  Arg Leu Gly Val Pro  Val Val His Asp Lys  Glu Gly Lys 
    1055                 1060                 1065             


Ile Ile  Ile Glu Pro Gly Phe  Leu Phe Thr Thr Ala  Lys Pro Lys 
    1070                 1075                 1080             


Glu Ser  Ala Glu Ala Asp Gly  Leu Ala Glu Ser Ser  Tyr Gly Arg 
    1085                 1090                 1095             


Trp Leu  Cys Asn Phe Ser Arg  Gln Arg Leu Asp Gly  Gly Ser Ala 
    1100                 1105                 1110             


Gly Ser  Pro Ser Ala Ala Gly  Pro Gly Phe Pro Ala  Ala Leu His 
    1115                 1120                 1125             


Asp Phe  Glu Met Ser Gly Asn  Met Ser Asp Asp Met  Lys Glu Ile 
    1130                 1135                 1140             


Thr Asn  Cys Val Arg Gln Ala  Met Arg Ser Gly Ser  Leu Glu Arg 
    1145                 1150                 1155             


Lys Val  Lys Ser Thr Ser Ser  Gln Thr Val Gly Leu  Ala Ser Val 
    1160                 1165                 1170             


Gly Thr  Gln Thr Ile Arg Thr  Val Ser Val Gly Leu  Gln Thr Asp 
    1175                 1180                 1185             


Pro Pro  Arg Ser Ser Leu His  Gly Lys Ala Trp Ser  Pro Arg Ser 
    1190                 1195                 1200             


Ser Ser  Leu Val Ser Val Arg  Ser Lys Gln Ile Ser  Ser Ser Leu 
    1205                 1210                 1215             


Asp Lys  Val His Ser Arg Ile  Glu Arg Pro Cys Cys  Ser Pro Lys 
    1220                 1225                 1230             


Tyr Gly  Ser Pro Lys Leu Gln  Arg Arg Ser Val Ser  Lys Leu Asp 
    1235                 1240                 1245             


Ser Ser  Lys Asp Arg Ser Leu  Trp Asn Leu His Gln  Gly Lys Gln 
    1250                 1255                 1260             


Asn Gly  Ser Ala Trp Ala Arg  Ser Thr Thr Thr Arg  Asp Ser Pro 
    1265                 1270                 1275             


Val Leu  Arg Asn Ile Asn Asp  Gly Leu Ser Ser Leu  Phe Ser Val 
    1280                 1285                 1290             


Val Glu  His Ser Gly Ser Thr  Glu Ser Val Trp Lys  Leu Gly Met 
    1295                 1300                 1305             


Ser Glu  Thr Arg Ala Lys Pro  Glu Pro Pro Lys Tyr  Gly Ile Val 
    1310                 1315                 1320             


Gln Glu  Phe Phe Arg Asn Val  Cys Gly Arg Ala Pro  Ser Pro Thr 
    1325                 1330                 1335             


Ser Ser  Ala Gly Glu Glu Gly  Thr Lys Lys Pro Glu  Pro Leu Ser 
    1340                 1345                 1350             


Pro Ala  Ser Tyr His Gln Pro  Glu Gly Val Ala Arg  Ile Leu Asn 
    1355                 1360                 1365             


Lys Lys  Ala Ala Lys Leu Gly  Ser Ser Glu Glu Val  Arg Leu Thr 
    1370                 1375                 1380             


Met Leu  Pro Gln Val Gly Lys  Asp Gly Val Leu Arg  Asp Gly Asp 
    1385                 1390                 1395             


Gly Ala  Val Val Leu Pro Asn  Glu Asp Ala Val Cys  Asp Cys Ser 
    1400                 1405                 1410             


Thr Gln  Ser Leu Thr Ser Cys  Phe Ala Arg Ser Ser  Arg Ser Ala 
    1415                 1420                 1425             


Ile Arg  His Ser Pro Ser Lys  Cys Arg Leu His Pro  Ser Glu Ser 
    1430                 1435                 1440             


Ser Trp  Gly Gly Glu Glu Arg  Ala Leu Pro Pro Ser  Glu 
    1445                 1450                 1455     


<210>  5249
<211>  3728
<212>  DNA
<213>  Homosapiens

<400>  5249
gatgtgtttt ctgcctttct ggactacttt gcctctaaga tgcagaaact gagtacaagg     60

gaaaggactc caaatcccca gtatgtcccc tgcaggagca gagttgaagg aggtcccacc    120

aggtctggtg ggtggccctg ctcaggctta cctccccctt gtaggggtca ctgggaactg    180

tcaactgcga aggactgtga tctccagtct ggtatggtct gctctggggt ccaagtgagg    240

aaagcataaa tcgggcaact ctctcccagt gagaagatag aaggagcttc tacagagaag    300

gacgagattg aggagctgcg ggccgagatg ctggagatgc gggacgtcta tatggaggag    360

gacgtgtatc agctgcagga gctgcgacag cagctggacc aggccagcaa gacctgccgc    420

atcctgcagt accggctgcg caaagccgag cgccgcagtc tccgtgccgc ccagaccggc    480

caggtggacg gcgagcttat ccgtggtctg gagcaggatg tcaaggtctc taaggacatc    540

tccatgcggc tgcataagga gctcgaggtg gtggagaaga aacgggcgcg gctggaggag    600

gagaacgaag agcttcgtca gcggctcatc gagactgagc tggctaagca ggtgctgcag    660

acggagctgg agcgaccgag agagcattcc ttgaagaaaa gaggaacccg ctccctgggg    720

aaggccgata agaagacttt ggtgcaggag gacagtgcag acctgaagtg ccagttgcac    780

tttgcaaagg aggagtcagc cctcatgtgc aagaagctca ctaagcttgc caaggagaat    840

gacagcatga aggaggagct gctgaagtac cgctcgctct atggggacct ggacagcgcg    900

ctgtcagccg aggagctggc cgatgccccc cactcgcggg agaccgagct gaaggtgcac    960

ctgaagctgg tggaggagga agccaacctg ctgagccgcc gcatcgtgga gctggaggtg   1020

gagaaccgag gcctgcgggc tgagatggac gacatgaagg atcatggagg tggctgtggg   1080

ggtcctgagg cacgcctggc cttctccgcg ctgggtggcg gagagtgcgg ggagagcttg   1140

gcagagctgc ggcgacacct gcagtttgtc gaagaggagg ccgagctgct gcggcgctcc   1200

tctgccgagc tcgaggacca gaacaagctg ctgctgaacg agctggccaa gttccgctcg   1260

gagcacgagc tggacgtggc gctgtcggag gacagttgtt ctgtgctcag cgaaccttca   1320

caggaggagc tggcggccgc caagctgcag atcggcgagc tcagcggcaa ggtcaagaag   1380

ctgcagtacg agaaccgcgt gctcctctcc aacctccagc gctgtgacct cgcctcctgc   1440

cagagtacgc ggcccatgct ggagacggac gccgaggccg gggactctgc ccagtgtgtg   1500

cctgctcccc tgggcgagac acacgagtcc catgcggtcc gactctgcag agccagggag   1560

gccgaggtgc tgcctgggct gagagagcag gccgccctgg tcagtaaggc catcgatgtc   1620

ctggtggctg atgccaatgg cttcacggct ggcctccggc tgtgtctgga caacgagtgt   1680

gctgacttcc ggctgcatga ggcccccgac aacagcgagg gccccaggga caccaagctc   1740

atccatgcca tcctggtgcg cctgagcgtg ctgcagcagg agctgaatgc cttcacgcgg   1800

aaggcagatg cagtcctcgg gtgctctgtc aaggaacagc aggagtcctt ctcatcactg   1860

ccccccttgg gctcccaggg gctctctaag gagattcttc tggcaaaaga ccttggctca   1920

gactttcagc cacctgactt cagggacctg ccggaatggg agcccaggat ccgagaggct   1980

ttccgcactg gtgacttgga ctctaagccc gaccccagcc ggagcttcag gccttaccga   2040

gctgaagaca atgattccta tgcctctgag atcaaggagc tgcagctggt gctggctgag   2100

gcccacgaca gcctccgggg cttgcaagag cagctctccc aggagcggca gctacgaaag   2160

gaggaggccg acaatttcaa ccagaaaatg gtccagctga aggaggacca gcagagggcg   2220

ctcctgaggc gggagtttga gctgcagagt ctgagcctcc agcggaggct ggagcagaaa   2280

ttctggagcc aggagaagaa catgctggtg caggagtccc agcaattcaa gcacaacttc   2340

ctgctgctct tcatgaagct caggtggttc ctcaagcgct ggcggcaggg caaggttttg   2400

cccagcgaag gggatgactt cctcgaggtg aacagcatga aggagctgta cttgctgatg   2460

gaggaagagg agataaacgc tcagcattct gataacaagg cctgcacggg ggacagctgg   2520

acccagaaca cgcccaatga gtacatcaag acactggccg acatgaaggt gacgctgaag   2580

gagctgtgct ggctgctccg ggatgaacgc cgtggtctga cggagcttca gcaacagttt   2640

gccaaggcca aggctacctg ggagacagag cgggcagagc tcaagggcca tacctcccag   2700

atggagctga agacagggaa gggggccggg gagcgggcag ggcccgactg gaaggcagcc   2760

ctacagcggg agcgtgagga gcagcagcac ctcctagctg agtcctacag cgctgtcatg   2820

gagctgactc ggcagctgca gatcagtgag cgcaactgga gccaggaaaa gctgcagctg   2880

gtggagcggc tgcagggtga gaagcagcag gtggagcagc aggtgaagga gctgcagaac   2940

cgcctaagcc agctgcagaa ggctgccgac ccctgggtcc tgaagcactc ggagctggag   3000

aagcaggaca acagctggaa ggagacacgc agtgagaaga tccacgacaa ggaggctgtt   3060

tccgaagttg agcttggagg aaatggttta aagagaacca aatctgtttc ttccatgtct   3120

gagtttgaaa gtttgctcga ctgttcccct taccttgctg gcggagatgc ccggggcaag   3180

aagctgccta acaaccctgc ctttggcttt gtgagctccg agccagggga tccagagaaa   3240

gacaccaagg agaagcctgg gctctcgtcg agggactgca accacctggg tgccctggcc   3300

tgccaggacc ccccagggag ccagaagctg cccttcctcc tcatcctggc ccctccccag   3360

cccccgccaa tactgtgaac ccccttccca ctcagcctgg tttcctggtg agggtcctgc   3420

agtcatgggc cctgggggac ccccagggca aggcccatgg gagggaaggg accaagggca   3480

tccttgggcc aactgtccac ctctcttgtc cactattctc tcctttccac ttctgtcttc   3540

aaaaggctcc ttcctaggat ggatcgggtg ctaggacaac tgcagtccaa tccaccagct   3600

ctccctgccc ctgtgtctta tttcagacat gagaataact gtacagtgta aacttataaa   3660

gcgtttttaa tggttgtaga ttggaaataa agtatgtcat atgaacagct aaaaaaaaaa   3720

aaaaaaaa                                                            3728


<210>  5250
<211>  1016
<212>  PRT
<213>  Homosapiens

<400>  5250

Met Leu Glu Met Arg Asp Val Tyr Met Glu Glu Asp Val Tyr Gln Leu 
1               5                   10                  15      


Gln Glu Leu Arg Gln Gln Leu Asp Gln Ala Ser Lys Thr Cys Arg Ile 
            20                  25                  30          


Leu Gln Tyr Arg Leu Arg Lys Ala Glu Arg Arg Ser Leu Arg Ala Ala 
        35                  40                  45              


Gln Thr Gly Gln Val Asp Gly Glu Leu Ile Arg Gly Leu Glu Gln Asp 
    50                  55                  60                  


Val Lys Val Ser Lys Asp Ile Ser Met Arg Leu His Lys Glu Leu Glu 
65                  70                  75                  80  


Val Val Glu Lys Lys Arg Ala Arg Leu Glu Glu Glu Asn Glu Glu Leu 
                85                  90                  95      


Arg Gln Arg Leu Ile Glu Thr Glu Leu Ala Lys Gln Val Leu Gln Thr 
            100                 105                 110         


Glu Leu Glu Arg Pro Arg Glu His Ser Leu Lys Lys Arg Gly Thr Arg 
        115                 120                 125             


Ser Leu Gly Lys Ala Asp Lys Lys Thr Leu Val Gln Glu Asp Ser Ala 
    130                 135                 140                 


Asp Leu Lys Cys Gln Leu His Phe Ala Lys Glu Glu Ser Ala Leu Met 
145                 150                 155                 160 


Cys Lys Lys Leu Thr Lys Leu Ala Lys Glu Asn Asp Ser Met Lys Glu 
                165                 170                 175     


Glu Leu Leu Lys Tyr Arg Ser Leu Tyr Gly Asp Leu Asp Ser Ala Leu 
            180                 185                 190         


Ser Ala Glu Glu Leu Ala Asp Ala Pro His Ser Arg Glu Thr Glu Leu 
        195                 200                 205             


Lys Val His Leu Lys Leu Val Glu Glu Glu Ala Asn Leu Leu Ser Arg 
    210                 215                 220                 


Arg Ile Val Glu Leu Glu Val Glu Asn Arg Gly Leu Arg Ala Glu Met 
225                 230                 235                 240 


Asp Asp Met Lys Asp His Gly Gly Gly Cys Gly Gly Pro Glu Ala Arg 
                245                 250                 255     


Leu Ala Phe Ser Ala Leu Gly Gly Gly Glu Cys Gly Glu Ser Leu Ala 
            260                 265                 270         


Glu Leu Arg Arg His Leu Gln Phe Val Glu Glu Glu Ala Glu Leu Leu 
        275                 280                 285             


Arg Arg Ser Ser Ala Glu Leu Glu Asp Gln Asn Lys Leu Leu Leu Asn 
    290                 295                 300                 


Glu Leu Ala Lys Phe Arg Ser Glu His Glu Leu Asp Val Ala Leu Ser 
305                 310                 315                 320 


Glu Asp Ser Cys Ser Val Leu Ser Glu Pro Ser Gln Glu Glu Leu Ala 
                325                 330                 335     


Ala Ala Lys Leu Gln Ile Gly Glu Leu Ser Gly Lys Val Lys Lys Leu 
            340                 345                 350         


Gln Tyr Glu Asn Arg Val Leu Leu Ser Asn Leu Gln Arg Cys Asp Leu 
        355                 360                 365             


Ala Ser Cys Gln Ser Thr Arg Pro Met Leu Glu Thr Asp Ala Glu Ala 
    370                 375                 380                 


Gly Asp Ser Ala Gln Cys Val Pro Ala Pro Leu Gly Glu Thr His Glu 
385                 390                 395                 400 


Ser His Ala Val Arg Leu Cys Arg Ala Arg Glu Ala Glu Val Leu Pro 
                405                 410                 415     


Gly Leu Arg Glu Gln Ala Ala Leu Val Ser Lys Ala Ile Asp Val Leu 
            420                 425                 430         


Val Ala Asp Ala Asn Gly Phe Thr Ala Gly Leu Arg Leu Cys Leu Asp 
        435                 440                 445             


Asn Glu Cys Ala Asp Phe Arg Leu His Glu Ala Pro Asp Asn Ser Glu 
    450                 455                 460                 


Gly Pro Arg Asp Thr Lys Leu Ile His Ala Ile Leu Val Arg Leu Ser 
465                 470                 475                 480 


Val Leu Gln Gln Glu Leu Asn Ala Phe Thr Arg Lys Ala Asp Ala Val 
                485                 490                 495     


Leu Gly Cys Ser Val Lys Glu Gln Gln Glu Ser Phe Ser Ser Leu Pro 
            500                 505                 510         


Pro Leu Gly Ser Gln Gly Leu Ser Lys Glu Ile Leu Leu Ala Lys Asp 
        515                 520                 525             


Leu Gly Ser Asp Phe Gln Pro Pro Asp Phe Arg Asp Leu Pro Glu Trp 
    530                 535                 540                 


Glu Pro Arg Ile Arg Glu Ala Phe Arg Thr Gly Asp Leu Asp Ser Lys 
545                 550                 555                 560 


Pro Asp Pro Ser Arg Ser Phe Arg Pro Tyr Arg Ala Glu Asp Asn Asp 
                565                 570                 575     


Ser Tyr Ala Ser Glu Ile Lys Glu Leu Gln Leu Val Leu Ala Glu Ala 
            580                 585                 590         


His Asp Ser Leu Arg Gly Leu Gln Glu Gln Leu Ser Gln Glu Arg Gln 
        595                 600                 605             


Leu Arg Lys Glu Glu Ala Asp Asn Phe Asn Gln Lys Met Val Gln Leu 
    610                 615                 620                 


Lys Glu Asp Gln Gln Arg Ala Leu Leu Arg Arg Glu Phe Glu Leu Gln 
625                 630                 635                 640 


Ser Leu Ser Leu Gln Arg Arg Leu Glu Gln Lys Phe Trp Ser Gln Glu 
                645                 650                 655     


Lys Asn Met Leu Val Gln Glu Ser Gln Gln Phe Lys His Asn Phe Leu 
            660                 665                 670         


Leu Leu Phe Met Lys Leu Arg Trp Phe Leu Lys Arg Trp Arg Gln Gly 
        675                 680                 685             


Lys Val Leu Pro Ser Glu Gly Asp Asp Phe Leu Glu Val Asn Ser Met 
    690                 695                 700                 


Lys Glu Leu Tyr Leu Leu Met Glu Glu Glu Glu Ile Asn Ala Gln His 
705                 710                 715                 720 


Ser Asp Asn Lys Ala Cys Thr Gly Asp Ser Trp Thr Gln Asn Thr Pro 
                725                 730                 735     


Asn Glu Tyr Ile Lys Thr Leu Ala Asp Met Lys Val Thr Leu Lys Glu 
            740                 745                 750         


Leu Cys Trp Leu Leu Arg Asp Glu Arg Arg Gly Leu Thr Glu Leu Gln 
        755                 760                 765             


Gln Gln Phe Ala Lys Ala Lys Ala Thr Trp Glu Thr Glu Arg Ala Glu 
    770                 775                 780                 


Leu Lys Gly His Thr Ser Gln Met Glu Leu Lys Thr Gly Lys Gly Ala 
785                 790                 795                 800 


Gly Glu Arg Ala Gly Pro Asp Trp Lys Ala Ala Leu Gln Arg Glu Arg 
                805                 810                 815     


Glu Glu Gln Gln His Leu Leu Ala Glu Ser Tyr Ser Ala Val Met Glu 
            820                 825                 830         


Leu Thr Arg Gln Leu Gln Ile Ser Glu Arg Asn Trp Ser Gln Glu Lys 
        835                 840                 845             


Leu Gln Leu Val Glu Arg Leu Gln Gly Glu Lys Gln Gln Val Glu Gln 
    850                 855                 860                 


Gln Val Lys Glu Leu Gln Asn Arg Leu Ser Gln Leu Gln Lys Ala Ala 
865                 870                 875                 880 


Asp Pro Trp Val Leu Lys His Ser Glu Leu Glu Lys Gln Asp Asn Ser 
                885                 890                 895     


Trp Lys Glu Thr Arg Ser Glu Lys Ile His Asp Lys Glu Ala Val Ser 
            900                 905                 910         


Glu Val Glu Leu Gly Gly Asn Gly Leu Lys Arg Thr Lys Ser Val Ser 
        915                 920                 925             


Ser Met Ser Glu Phe Glu Ser Leu Leu Asp Cys Ser Pro Tyr Leu Ala 
    930                 935                 940                 


Gly Gly Asp Ala Arg Gly Lys Lys Leu Pro Asn Asn Pro Ala Phe Gly 
945                 950                 955                 960 


Phe Val Ser Ser Glu Pro Gly Asp Pro Glu Lys Asp Thr Lys Glu Lys 
                965                 970                 975     


Pro Gly Leu Ser Ser Arg Asp Cys Asn His Leu Gly Ala Leu Ala Cys 
            980                 985                 990         


Gln Asp Pro Pro Gly Ser Gln Lys  Leu Pro Phe Leu Leu  Ile Leu Ala 
        995                 1000                 1005             


Pro Pro  Gln Pro Pro Pro Ile  Leu 
    1010                 1015     


<210>  5251
<211>  2041
<212>  DNA
<213>  Homosapiens

<400>  5251
acaggagaat gagaggcctc cgctggcgtt acactcggct gcccagccag gtggaggaca     60

ccctgtctgg ggaggagggt aacgaagagg aagaggagga ggaggcagct ccagacccag    120

ctgctgctcc tgaggatccc acggtgcccc agctgacaga agccagccag gttttgagtg    180

cctcagagat tcggcagctc agctttcact tcccaccaag agtcaccggc catccctgga    240

gtctggtctt ctgcacgtca agggacggtt tcagcctgca gagcctgtac cggcggatgg    300

agggctgcag cgggccagtg ctgctggtgc tcagggacca ggacgggcag atatttggag    360

ccttctcctc ctcggctatc cgactcagca aaggcttcta tggtactggc gagacattcc    420

tcttctcctt ctccccacag ctgaaggtct ttaagtggac tggaagcaac tctttctttg    480

tgaagggaga cttggattca ctgatgatgg gcagtggcag tggccggttt gggctgtggt    540

tggatggaga cttgttccgc gggggaagct ccccttgccc gaccttcaac aacgaggtgc    600

tggcccggca ggagcagttc tgcatccagg agctggaggc ttggcttctc agctgacagc    660

cctgcggcaa cagaattcta tgattgaagc ctctaaatga attgtgcagg agagggagtt    720

tgtaaacaac tgactacaga cattcacatt gggtcatctt taaaaagctg gactctgctt    780

ttggatgctt ctcggaggcg agttggattt tggactgaag tactgtcgtt ccattccttt    840

ttttgaggtg ttatgagtgg ggctataaca tcgccatcct attaagaaga gagagaaaaa    900

caggcaatag agaaaagcca gtttccatca tcttatttct gagtgaaagt ctcaagtgcg    960

cacatcctca tcttgcatat agattgcttc tagctgtcct caatccaggg aaactccaaa   1020

ttacatatgc cctgtgcttg gggcaaatta gaaacactac agtcttacgc aggaagagcc   1080

ttcatgaaaa cagccactgg cctctgcaga gatgactggg agcagcatac cactgcccac   1140

ctctatggcc tccttcacac accttcacgg agcacaaact ctgtcctgtt ttcccaggag   1200

aaagacggga tgcactgaac ccctagcttc tctctcgcct ggtcccctct gcaataaaag   1260

gcccaggtct acaagatggc aaagaagggg aggaagaaca gtatgtacct gcagaattta   1320

aatttttctc tgcatcaaag ctctaacgtt ggtcccatca gcataggctc cagccaaaga   1380

agctcctcca cccaaaataa gggagagatc caaagggagg cgatacaatg acgtgaaacc   1440

atagaggtaa gaagcaaggc ctcctaatac ttgactctat gctaaactgt tctgaacttg   1500

tgggtagatc ttctttggtt acaagatgat gcacgatctt ggagagcctc tgttgtacca   1560

ggaatacaat gctggtggga ggattcgtgc tcctcatctg cttatttgct ctcagatcca   1620

ttcttcactc ttcctctccc tactctgtct cacaggagct actccggtaa attacatttc   1680

tcagctccca tgcctgttgg tttccagtta gatttggtca gtgggaggct ctggtgggag   1740

actggaggtg agaagagggc agagaagtca ggttttttct ctccctacct cctctggcac   1800

gagcggcagt ggcagtgact attctgtggt tctagctttt gcaggtggcc ccagctcctg   1860

gactcccacc tgctcccttg gtctctccta tcctagaggt ggtagcagct tcctgctgtt   1920

gaatcactgt cctctatgct catttagctc tgccaaaact tttgtatctc acccccatgt   1980

taaatttttt ctgttgaact acactggatc tgacttgata gaactattaa aaatagtttt   2040

t                                                                   2041


<210>  5252
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  5252

Met Arg Gly Leu Arg Trp Arg Tyr Thr Arg Leu Pro Ser Gln Val Glu 
1               5                   10                  15      


Asp Thr Leu Ser Gly Glu Glu Gly Asn Glu Glu Glu Glu Glu Glu Glu 
            20                  25                  30          


Ala Ala Pro Asp Pro Ala Ala Ala Pro Glu Asp Pro Thr Val Pro Gln 
        35                  40                  45              


Leu Thr Glu Ala Ser Gln Val Leu Ser Ala Ser Glu Ile Arg Gln Leu 
    50                  55                  60                  


Ser Phe His Phe Pro Pro Arg Val Thr Gly His Pro Trp Ser Leu Val 
65                  70                  75                  80  


Phe Cys Thr Ser Arg Asp Gly Phe Ser Leu Gln Ser Leu Tyr Arg Arg 
                85                  90                  95      


Met Glu Gly Cys Ser Gly Pro Val Leu Leu Val Leu Arg Asp Gln Asp 
            100                 105                 110         


Gly Gln Ile Phe Gly Ala Phe Ser Ser Ser Ala Ile Arg Leu Ser Lys 
        115                 120                 125             


Gly Phe Tyr Gly Thr Gly Glu Thr Phe Leu Phe Ser Phe Ser Pro Gln 
    130                 135                 140                 


Leu Lys Val Phe Lys Trp Thr Gly Ser Asn Ser Phe Phe Val Lys Gly 
145                 150                 155                 160 


Asp Leu Asp Ser Leu Met Met Gly Ser Gly Ser Gly Arg Phe Gly Leu 
                165                 170                 175     


Trp Leu Asp Gly Asp Leu Phe Arg Gly Gly Ser Ser Pro Cys Pro Thr 
            180                 185                 190         


Phe Asn Asn Glu Val Leu Ala Arg Gln Glu Gln Phe Cys Ile Gln Glu 
        195                 200                 205             


Leu Glu Ala Trp Leu Leu Ser 
    210                 215 


<210>  5253
<211>  4464
<212>  DNA
<213>  Homosapiens

<400>  5253
cgaagacact cacctgtgga gcctgtgcac gtaggtagag gcggcggctc tgagtccagg     60

agctccagtg ggcagctccc cagcaccagc catgaactac gtggggcagc tggcggagac    120

ggtgtttggg acggtgaagg agctgtaccg gggcctgaac ccagccacac tgagcggcgg    180

cattgacgtg ctggtggtga agcaggtgga cggctcgttc cggtgctcac ccttccacgt    240

gcgttttggc aagctgggcg tcctgcggtc gcgggagaag gtggtagaca ttgagctcaa    300

tggggagcct gtggacttgc acatgaagct tggggacagc ggggaggcct tctttgttca    360

ggagctggag agcgatgatg aacatgtgcc tcccggcctg tgcacctcac ccatcccttg    420

ggggggtctg tctggcttcc cctcggactc ccagctgggc actgccagtg agcctgaggg    480

cctcgtcatg gcaggcacgg cctccactgg gcggaggaag aggcgtcgca ggaggaaacc    540

caagcagaaa gaggatgcag tggcaactga ttctagtcca gaggaactgg aggcaggcgc    600

tgagagtgag ctatccctgc cggaaaagct gaggccagag cccccaggtg tccagttgga    660

agagaagtct tcactgcagc ccaaagacat ctacccctac tcggatggcg agtggccccc    720

ccaggccagc ctctcagcag gtgagctaac atcccctaag agcgactcgg agctggaggt    780

gcggaccccg gagcccagtc ccctaagagc cgagtcccac atgcagtggg cctgggggag    840

gctgcctaag gtggccagag ctgagcggcc cgagtcctca gtggtccttg aaggcagagc    900

tggggcaacc tctcctcctc ggggaggacc cagcactccc tctacctctg tggctggcgg    960

cgtggaccct ttgggactcc caatccagca aacagaggct ggtgccgacc ttcagcctga   1020

cacagaggat cccactctag tgggtccccc tctccacacc ccagagacag aggaaagcaa   1080

gactcagagc tctggggaca tgggcctccc tcctgcctcc aagtcatgga gctgggccac   1140

tctggaggtt ccagttccca ccgggcagcc agagagggtc tccaggggga aaggctcccc   1200

aaagagaagc cagcacctgg gccccagtga catctacctg gatgacttgc cctccctgga   1260

ctctgagaat gcagcgcttt acttccccca aagtgactct gggctggggg ccagaagatg   1320

gagtgaaccc agcagtcaga agtccctgag ggaccccaac cctgaacatg aacctgaacc   1380

cactctggac acagtggata caatagcact gtccctctgt ggtggactgg ctgacagccg   1440

ggacatctcc ctagagaaat tcaaccagca cagcgtctct taccaggacc tcaccaaaaa   1500

ccccggactt ttggatgacc caaacctagt ggtgaaaatc aatggaaagc attataactg   1560

ggctgtggct gcccccatga tcctctccct gcaagccttc cagaaaaact tgcccaagag   1620

caccatggac aagctggaga gggagaagat gccccggaag ggtgggcgat ggtggttttc   1680

ctggcgacgc agggacttcc tggccgagga gcgcagtgcc cagaaggaga agactgcagc   1740

caaggagcag cagggggaga agacagaagt cctgagcagt gatgacgatg ccccagacag   1800

ccctgtgatc ctggagatcc cctccttgcc accctccact ccaccctcca ctcctaccta   1860

caagaagtcc ctccgcctct cctccgatca gatccggcgc ctgaacctgc aagaaggtgc   1920

caatgatgtg gtcttcagcg tgaccactca gtaccagggc acctgccgct gcaaggccac   1980

catctacctg tggaaatggg acgacaaggt ggtcatctct gacatcgacg gcaccatcac   2040

caagtcagat gctctgggcc atatcctgcc ccagctgggg aaagactgga cacaccaggg   2100

catcaccagt ctctatcaca aaatccaact aaatgggtac aagttcctgt actgctcggc   2160

gcgggccatt ggcatggcgg acctcaccaa ggggtacctg cagtgggtga gcgagggggg   2220

ctgtagcctc cccaagggcc ccatccttct gtctcccagc agcctcttct ctgccctcca   2280

cagagaggtg atcgagaaga aaccagaggt gttcaaggtc gcctgcctga gtgacatcca   2340

gcagctgttt ctgccccacg gacagccctt ctatgctgcc tttgggaata ggcccaatga   2400

tgtctttgcc taccggcagg tgggcctgcc tgagtcacgc atcttcacag tcaacccccg   2460

gggagagctc atccaggagc tcataaagaa ccacaaatcc acgtatgagc ggcttggtga   2520

agtggtcgag ctcctcttcc cacctgtggc ccgtggcccc agcacagacc tggccaaccc   2580

tgaatacagt aacttctgct actggcggga gccactgcct gctgtggacc ttgataccct   2640

ggactgaacc tgccctggct ggctcctcct ccctggcccg gcccaggact ggctaggtgt   2700

cctggggtat aggagggtgg gaattggagt gtcatggggc aaacccactg aaggggaagg   2760

aggaggctgc aggttggttg gcagctagag agactccccc atcttccccg tcatattttt   2820

gccagctaag ctgcagctgc tccaggcgtc agtgtggcac tgtcctgggg caattagctt   2880

gtcatctggg cccttgcagg gttctttttt tttttttttt tttttttttc ctgagacagg   2940

gtcttgttct gttgcccagg ctggagtgca gtggcatgat ctctcggctc actgcaacct   3000

ccgcctcccg ggttcaagcg attcacctgc ctcagcctcc caagtagctg ggattacagg   3060

cgtgtaccac cacgcctggc taattttcgt gtttttagta gagatgggtt ttcaccacat   3120

tggccaggct ggtctcgaac tcctgacctc aagtgatttg cccacctcgg cctcccaaag   3180

tgctgggatt acaggcatga gctaccatgc caggcctcct tgcagggttt tctatgccct   3240

tgatatctgt ctccctgtca acctgggacc ttgctgtaag tcttgatagg acagggagaa   3300

gagggaggcc ctaccgaggc tcgaggcttc agtgaagggt gacagcagtg ggagtgtggt   3360

acagcctctg gaaggacaca gtgttctccc cgccccttgt ctgggagcca ggactgtacc   3420

ctccgaagcc agacatcact gccaacatat cccccttgct ggtgccctgg catctcagca   3480

catgacacac acccacacct gcaggctgtg gttccggctt ggcctgctcc ccgtccggct   3540

gctgccgctg cctctctcca gacctcgctt aaggacagtc ccaaactcag ctggggcagg   3600

tgttggcctg aaagtcctcc cccagcctct gctggccagc ttggtgctca cagctgctgg   3660

gtaagctctt gcctaaggag ctgtgggaag cagggctgat gccccagcaa cctctcctcc   3720

cactgtcttt gaagaaagta gctttagacc ggctaaaagc tttaatccag agcctgccct   3780

actctgatag taccagagtg gagggcagaa taccaaatgt ccaggaacca aaggcagggc   3840

tgtggggacc tgaagagcgg cacagtgggg cccgtgctgc tgtgggggaa actgaggctg   3900

ggagcctcag cagagaccgg tgtcaagagt ctctgggaac tgcataggcc tgaggaacat   3960

gcattttcaa gttgtccatt gatggtttcg tacctgaatt tctcaccttt tgtgaacatc   4020

ttgggagggt gggggttttg caggggtgtt aaaagcaagg cttggagccc ctttcctcca   4080

gctggtggct ccttctcagg gcctggcctc attcaggcca ctttgtagag aaatgccctg   4140

acctcgcagg aaggatttcc ccacccccaa gtggaaggaa gaggacagtg tgggcaccag   4200

agggccctgg aaacatctta ggggaaggaa aggaaaagga taaatttgga gtggggggtc   4260

tctaaacaga ttgcctggat tccgttcttt cctggggttc tacagctgcc taagccctca   4320

ccttggggga ggatcaaagg gaataaagag aactcttggc tgaaaaaaaa aaaaaaaaaa   4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   4440

aaaaaaaaaa aaaaaaaaaa aaaa                                          4464


<210>  5254
<211>  851
<212>  PRT
<213>  Homosapiens

<400>  5254

Met Asn Tyr Val Gly Gln Leu Ala Glu Thr Val Phe Gly Thr Val Lys 
1               5                   10                  15      


Glu Leu Tyr Arg Gly Leu Asn Pro Ala Thr Leu Ser Gly Gly Ile Asp 
            20                  25                  30          


Val Leu Val Val Lys Gln Val Asp Gly Ser Phe Arg Cys Ser Pro Phe 
        35                  40                  45              


His Val Arg Phe Gly Lys Leu Gly Val Leu Arg Ser Arg Glu Lys Val 
    50                  55                  60                  


Val Asp Ile Glu Leu Asn Gly Glu Pro Val Asp Leu His Met Lys Leu 
65                  70                  75                  80  


Gly Asp Ser Gly Glu Ala Phe Phe Val Gln Glu Leu Glu Ser Asp Asp 
                85                  90                  95      


Glu His Val Pro Pro Gly Leu Cys Thr Ser Pro Ile Pro Trp Gly Gly 
            100                 105                 110         


Leu Ser Gly Phe Pro Ser Asp Ser Gln Leu Gly Thr Ala Ser Glu Pro 
        115                 120                 125             


Glu Gly Leu Val Met Ala Gly Thr Ala Ser Thr Gly Arg Arg Lys Arg 
    130                 135                 140                 


Arg Arg Arg Arg Lys Pro Lys Gln Lys Glu Asp Ala Val Ala Thr Asp 
145                 150                 155                 160 


Ser Ser Pro Glu Glu Leu Glu Ala Gly Ala Glu Ser Glu Leu Ser Leu 
                165                 170                 175     


Pro Glu Lys Leu Arg Pro Glu Pro Pro Gly Val Gln Leu Glu Glu Lys 
            180                 185                 190         


Ser Ser Leu Gln Pro Lys Asp Ile Tyr Pro Tyr Ser Asp Gly Glu Trp 
        195                 200                 205             


Pro Pro Gln Ala Ser Leu Ser Ala Gly Glu Leu Thr Ser Pro Lys Ser 
    210                 215                 220                 


Asp Ser Glu Leu Glu Val Arg Thr Pro Glu Pro Ser Pro Leu Arg Ala 
225                 230                 235                 240 


Glu Ser His Met Gln Trp Ala Trp Gly Arg Leu Pro Lys Val Ala Arg 
                245                 250                 255     


Ala Glu Arg Pro Glu Ser Ser Val Val Leu Glu Gly Arg Ala Gly Ala 
            260                 265                 270         


Thr Ser Pro Pro Arg Gly Gly Pro Ser Thr Pro Ser Thr Ser Val Ala 
        275                 280                 285             


Gly Gly Val Asp Pro Leu Gly Leu Pro Ile Gln Gln Thr Glu Ala Gly 
    290                 295                 300                 


Ala Asp Leu Gln Pro Asp Thr Glu Asp Pro Thr Leu Val Gly Pro Pro 
305                 310                 315                 320 


Leu His Thr Pro Glu Thr Glu Glu Ser Lys Thr Gln Ser Ser Gly Asp 
                325                 330                 335     


Met Gly Leu Pro Pro Ala Ser Lys Ser Trp Ser Trp Ala Thr Leu Glu 
            340                 345                 350         


Val Pro Val Pro Thr Gly Gln Pro Glu Arg Val Ser Arg Gly Lys Gly 
        355                 360                 365             


Ser Pro Lys Arg Ser Gln His Leu Gly Pro Ser Asp Ile Tyr Leu Asp 
    370                 375                 380                 


Asp Leu Pro Ser Leu Asp Ser Glu Asn Ala Ala Leu Tyr Phe Pro Gln 
385                 390                 395                 400 


Ser Asp Ser Gly Leu Gly Ala Arg Arg Trp Ser Glu Pro Ser Ser Gln 
                405                 410                 415     


Lys Ser Leu Arg Asp Pro Asn Pro Glu His Glu Pro Glu Pro Thr Leu 
            420                 425                 430         


Asp Thr Val Asp Thr Ile Ala Leu Ser Leu Cys Gly Gly Leu Ala Asp 
        435                 440                 445             


Ser Arg Asp Ile Ser Leu Glu Lys Phe Asn Gln His Ser Val Ser Tyr 
    450                 455                 460                 


Gln Asp Leu Thr Lys Asn Pro Gly Leu Leu Asp Asp Pro Asn Leu Val 
465                 470                 475                 480 


Val Lys Ile Asn Gly Lys His Tyr Asn Trp Ala Val Ala Ala Pro Met 
                485                 490                 495     


Ile Leu Ser Leu Gln Ala Phe Gln Lys Asn Leu Pro Lys Ser Thr Met 
            500                 505                 510         


Asp Lys Leu Glu Arg Glu Lys Met Pro Arg Lys Gly Gly Arg Trp Trp 
        515                 520                 525             


Phe Ser Trp Arg Arg Arg Asp Phe Leu Ala Glu Glu Arg Ser Ala Gln 
    530                 535                 540                 


Lys Glu Lys Thr Ala Ala Lys Glu Gln Gln Gly Glu Lys Thr Glu Val 
545                 550                 555                 560 


Leu Ser Ser Asp Asp Asp Ala Pro Asp Ser Pro Val Ile Leu Glu Ile 
                565                 570                 575     


Pro Ser Leu Pro Pro Ser Thr Pro Pro Ser Thr Pro Thr Tyr Lys Lys 
            580                 585                 590         


Ser Leu Arg Leu Ser Ser Asp Gln Ile Arg Arg Leu Asn Leu Gln Glu 
        595                 600                 605             


Gly Ala Asn Asp Val Val Phe Ser Val Thr Thr Gln Tyr Gln Gly Thr 
    610                 615                 620                 


Cys Arg Cys Lys Ala Thr Ile Tyr Leu Trp Lys Trp Asp Asp Lys Val 
625                 630                 635                 640 


Val Ile Ser Asp Ile Asp Gly Thr Ile Thr Lys Ser Asp Ala Leu Gly 
                645                 650                 655     


His Ile Leu Pro Gln Leu Gly Lys Asp Trp Thr His Gln Gly Ile Thr 
            660                 665                 670         


Ser Leu Tyr His Lys Ile Gln Leu Asn Gly Tyr Lys Phe Leu Tyr Cys 
        675                 680                 685             


Ser Ala Arg Ala Ile Gly Met Ala Asp Leu Thr Lys Gly Tyr Leu Gln 
    690                 695                 700                 


Trp Val Ser Glu Gly Gly Cys Ser Leu Pro Lys Gly Pro Ile Leu Leu 
705                 710                 715                 720 


Ser Pro Ser Ser Leu Phe Ser Ala Leu His Arg Glu Val Ile Glu Lys 
                725                 730                 735     


Lys Pro Glu Val Phe Lys Val Ala Cys Leu Ser Asp Ile Gln Gln Leu 
            740                 745                 750         


Phe Leu Pro His Gly Gln Pro Phe Tyr Ala Ala Phe Gly Asn Arg Pro 
        755                 760                 765             


Asn Asp Val Phe Ala Tyr Arg Gln Val Gly Leu Pro Glu Ser Arg Ile 
    770                 775                 780                 


Phe Thr Val Asn Pro Arg Gly Glu Leu Ile Gln Glu Leu Ile Lys Asn 
785                 790                 795                 800 


His Lys Ser Thr Tyr Glu Arg Leu Gly Glu Val Val Glu Leu Leu Phe 
                805                 810                 815     


Pro Pro Val Ala Arg Gly Pro Ser Thr Asp Leu Ala Asn Pro Glu Tyr 
            820                 825                 830         


Ser Asn Phe Cys Tyr Trp Arg Glu Pro Leu Pro Ala Val Asp Leu Asp 
        835                 840                 845             


Thr Leu Asp 
    850     


<210>  5255
<211>  669
<212>  DNA
<213>  Homosapiens

<400>  5255
atggcctgcc ggcatctgtt ggtgtgctcc tccgccagcg tgcttccccg ccagcatggt     60

ccccgacagg tgctcctccg ccagcgtggt cctcggctag gtgctcctct gccagcgtgc    120

tcccccgcca gatgctcctc tgccagcggg gtcctcagtc aggtgctcct ctgccagcgt    180

gctcccccgc caggtgctcc tctgccagca tgctcccccg ccagcatgct cctctgccag    240

gtgctccccc accaggtgct cctccttcag atgctcctcc agcaggtgct cccccgccag    300

cgtgctcctc caccagcgtg ctccttcgcc agcgtgctcc tccgccaggt gctcctcctc    360

caggtgctcc cccaccagcg tgctccccca ccagcgtgct cctccgccag gtgctcctcc    420

accagcgtgc tcctccactg ctcctccgcc agcatgctca tccgccaggt gctcctttgc    480

cagcgtgctc ctccactgct cctctgccag cgtgctcctc cgccaggtgc tcctccgcta    540

ggtgctcctc tgctaggtgc tcccctgcta ggtgctcccc tcgacgtctt gtccccgtcc    600

agctgcttgt gtcttcttcc gctgatgtgc tcctctccac acccggccgc ctgtgtgtct    660

gcccgctag                                                            669


<210>  5256
<211>  222
<212>  PRT
<213>  Homosapiens

<400>  5256

Met Ala Cys Arg His Leu Leu Val Cys Ser Ser Ala Ser Val Leu Pro 
1               5                   10                  15      


Arg Gln His Gly Pro Arg Gln Val Leu Leu Arg Gln Arg Gly Pro Arg 
            20                  25                  30          


Leu Gly Ala Pro Leu Pro Ala Cys Ser Pro Ala Arg Cys Ser Ser Ala 
        35                  40                  45              


Ser Gly Val Leu Ser Gln Val Leu Leu Cys Gln Arg Ala Pro Pro Pro 
    50                  55                  60                  


Gly Ala Pro Leu Pro Ala Cys Ser Pro Ala Ser Met Leu Leu Cys Gln 
65                  70                  75                  80  


Val Leu Pro His Gln Val Leu Leu Leu Gln Met Leu Leu Gln Gln Val 
                85                  90                  95      


Leu Pro Arg Gln Arg Ala Pro Pro Pro Ala Cys Ser Phe Ala Ser Val 
            100                 105                 110         


Leu Leu Arg Gln Val Leu Leu Leu Gln Val Leu Pro His Gln Arg Ala 
        115                 120                 125             


Pro Pro Pro Ala Cys Ser Ser Ala Arg Cys Ser Ser Thr Ser Val Leu 
    130                 135                 140                 


Leu His Cys Ser Ser Ala Ser Met Leu Ile Arg Gln Val Leu Leu Cys 
145                 150                 155                 160 


Gln Arg Ala Pro Pro Leu Leu Leu Cys Gln Arg Ala Pro Pro Pro Gly 
                165                 170                 175     


Ala Pro Pro Leu Gly Ala Pro Leu Leu Gly Ala Pro Leu Leu Gly Ala 
            180                 185                 190         


Pro Leu Asp Val Leu Ser Pro Ser Ser Cys Leu Cys Leu Leu Pro Leu 
        195                 200                 205             


Met Cys Ser Ser Pro His Pro Ala Ala Cys Val Ser Ala Arg 
    210                 215                 220         


<210>  5257
<211>  1202
<212>  DNA
<213>  Homosapiens

<400>  5257
tggcggggct tccggtcggg agggtccgcc cgctctcgcg tcctttgctg ggtccagaca     60

ccggttccgt tgcaaacatt tttaaagggc tggttattct tcctgaaatg agtttggtga    120

ttagaaatct gcagcgagtc atccccatca ggagagcgcc acttcgcagt aagatcgaga    180

ttgtaaggag gattttagga gtgcagaaat ttgacctggg gatcatctgt gttgacaaca    240

agaatattca gcacattaat agaatctaca gagatagaaa tgtcccaacc gatgtgcttt    300

cttttccatt tcatgagcat ctgaaagcag gtgaatttcc ccagcctgat tttccagatg    360

actacaattt gggagacatt ttcctaggag tggagtatat cttccatcag tgtaaagaaa    420

atgaagatta caatgacgtc ctgactgtaa gcggggatgc tgaaatcata taacctggct    480

catggaacat gggccttgca aaggggtcaa gatcacaacc ctgcatccat gtgtgtccgt    540

gggtaccgta agggctactg ggggaagaac ctgtaagcag ggtgtgagga gcacccaggc    600

tgggtaggga ctgcatgccc catgccacag ttgaaggagg gagagaacac gctgtgaaaa    660

cacagaagct cccagagaag ccttctcagc ttttatctct ggagtagagc agactatgtt    720

gagctaacac agacctgctg aatcagcttc tttctgagct gccagaagta cagaagttgg    780

agcctccacc accttccaga tctgtttctc ctcagtgtaa tccacctatg ggttcttcct    840

gcccactgca cagacaaaac caattcactg caattgtggt attgcagtag agaaagagtt    900

taacacagag ctagccaagc agaaaggctg gagttattat tcaactcaat ctcccagaga    960

actcagaggc tacagtttct acaggcaatt tggcaggcag gggctaggga atgcctgctg   1020

ctgatcggct gcagacggac catggggtgt caacgatttt tgtcccctga gtccgcctct   1080

gcgtggagcc acgggatcag ctgagtcatg agtctcaggt ccaggtggag tctgtaggtt   1140

gccagaactc aaaagtctga aaaacatccc aaaagaccat taaaaaaaaa aaaaaaaaaa   1200

aa                                                                  1202


<210>  5258
<211>  121
<212>  PRT
<213>  Homosapiens

<400>  5258

Met Ser Leu Val Ile Arg Asn Leu Gln Arg Val Ile Pro Ile Arg Arg 
1               5                   10                  15      


Ala Pro Leu Arg Ser Lys Ile Glu Ile Val Arg Arg Ile Leu Gly Val 
            20                  25                  30          


Gln Lys Phe Asp Leu Gly Ile Ile Cys Val Asp Asn Lys Asn Ile Gln 
        35                  40                  45              


His Ile Asn Arg Ile Tyr Arg Asp Arg Asn Val Pro Thr Asp Val Leu 
    50                  55                  60                  


Ser Phe Pro Phe His Glu His Leu Lys Ala Gly Glu Phe Pro Gln Pro 
65                  70                  75                  80  


Asp Phe Pro Asp Asp Tyr Asn Leu Gly Asp Ile Phe Leu Gly Val Glu 
                85                  90                  95      


Tyr Ile Phe His Gln Cys Lys Glu Asn Glu Asp Tyr Asn Asp Val Leu 
            100                 105                 110         


Thr Val Ser Gly Asp Ala Glu Ile Ile 
        115                 120     


<210>  5259
<211>  1058
<212>  DNA
<213>  Homosapiens

<400>  5259
tggcggggct tccggtcggg agggtccgcc cgctctcgcg tcctttgctg ggtccagaca     60

ccggtacgtc cgggcgggtt tttagtctcc caagcgagag cgtcgcattc acccgcgtgg    120

gtctgcgggc gccccagacc ccagaggacc cggcccccaa cgcttacctg tcccctctcc    180

tgtccctccc ccattccagc cccttctctc cccagccgtt gcccctcccc gcaccccgcc    240

gcgtccgcgc gcctctctcc gcgcgcaccc ccaacccgcc cccttttctc tgggaaccgc    300

tccttccgct ccgcccgcct ggagtccttc tggccggatt ccgcggcatc cttccataga    360

ccctcgttgt tgcttcctcc ttgtggttcc gttgcaaaca tttttaaagg gctggttatt    420

cttcctgaaa tgagtttggt gattagaaat ctgcagcgag tcatccccat caggagagcg    480

ccacttcgca gtaagatcga gattgtaagg aggattttag gagtgcagaa atttgacctg    540

gggatcatct gtgttgacaa caagaatatt cagcacatta atagaatcta cagagataga    600

aatgtcccaa ccgatgtgct ttcttttcca tttcatgagc atctgaaagc aggtgaattt    660

ccccagcctg attttccaga tgactacaat ttgggagaca ttttcctagg agtggagtat    720

atcttccatc agtgtaaaga aaatgaagat tacaatgacg tcctgactgt gacggccacc    780

cacggactct gtcacttgct gggattcaca cacggcacgg aggcagagtg gcagcagatg    840

ttccagaagg agaaggcggt gctggacgag ctgggccgac gcacggggac ccggctgcag    900

cccctgaccc ggggcctctt cggagggagc tgagggccgc gttccttctg aaagcgggac    960

gcgggagggg tggaggctgc ggggagccgg ggtcgcacac gaataaataa cgaatgaacg   1020

tacgagggga acctcctctt atttccttca aaaaaaaa                           1058


<210>  5260
<211>  167
<212>  PRT
<213>  Homosapiens

<400>  5260

Met Ser Leu Val Ile Arg Asn Leu Gln Arg Val Ile Pro Ile Arg Arg 
1               5                   10                  15      


Ala Pro Leu Arg Ser Lys Ile Glu Ile Val Arg Arg Ile Leu Gly Val 
            20                  25                  30          


Gln Lys Phe Asp Leu Gly Ile Ile Cys Val Asp Asn Lys Asn Ile Gln 
        35                  40                  45              


His Ile Asn Arg Ile Tyr Arg Asp Arg Asn Val Pro Thr Asp Val Leu 
    50                  55                  60                  


Ser Phe Pro Phe His Glu His Leu Lys Ala Gly Glu Phe Pro Gln Pro 
65                  70                  75                  80  


Asp Phe Pro Asp Asp Tyr Asn Leu Gly Asp Ile Phe Leu Gly Val Glu 
                85                  90                  95      


Tyr Ile Phe His Gln Cys Lys Glu Asn Glu Asp Tyr Asn Asp Val Leu 
            100                 105                 110         


Thr Val Thr Ala Thr His Gly Leu Cys His Leu Leu Gly Phe Thr His 
        115                 120                 125             


Gly Thr Glu Ala Glu Trp Gln Gln Met Phe Gln Lys Glu Lys Ala Val 
    130                 135                 140                 


Leu Asp Glu Leu Gly Arg Arg Thr Gly Thr Arg Leu Gln Pro Leu Thr 
145                 150                 155                 160 


Arg Gly Leu Phe Gly Gly Ser 
                165         


<210>  5261
<211>  1827
<212>  DNA
<213>  Homosapiens

<400>  5261
cgagcacgag cgggaggtgc tgcacaaggc gctggaggag aataacaact tcagccgcca     60

ggcggaggag aagctcaact acaaatggag ctcagcaagg agatccgcga ggcgcacctg    120

gccgcactgc gcgagcggct gcgcgaggag ctgcacgcgg ccgaggtgcg caggaacaag    180

gagcagcgag aggagatgtc gggctaaggg cccgggacgg gcggcgccca tcctgcgaga    240

gaacacgttc gggttttggt tttgtttcgt tcacctctgt ctagatgcaa cttttgttcc    300

tcctccccca cccccgcccc cagcttcatg cttctcttcc gcactcagcc gccctgccct    360

gtcctcgtgg tgagtcgctg accacggctt cccctgcagg agccgccggg cgtgagacgc    420

ggtccctcgg tgcagacacc aggccgggcg cggctgggtc ccccgggggc cctgtgagag    480

aggtggcggt gaccgtggta aacccagggc ggtggcgtgg gatcgcgggt ccttacgctg    540

ggctgtctgg tcagcacgtg caggtcaggg caggtcctct gagccggcgc ccctggccag    600

caggcgaggc tacagtacct gctgtctttc caggaggaag gggctcccca tgagggaggg    660

gcaacggggg aggcgggtga tggtgtctgg gagcctgcgt gtgcagccgg agcttgttga    720

actggcaggg ggtgggtggg ggctgcagct ttccttaatg tggttgcaca ggggtcctct    780

gagaccaccc ggcctgaggt ggacaccctg ggccttcctg gaagcctgca gttggggacc    840

tgccctgagt ctgctgggga gtgggcattc tctgccaggg acccatgagc aggctgcatg    900

gtctagaggt tgtgggcagc atggacagtc ccccactcag aagtgcaaga gttccaaaga    960

gcctctggcc caggcgcctc cggctttgca gatgtccttg aaagacccac cctagagccc   1020

tttggagtgc tggcccctcc tgtgtcctct gccctggtgg aagtggcagc cacaagtcct   1080

cctcagggag ccccaagggg gattttgtgg gaccgctgcc cacagatcca ggtgttggaa   1140

gggcagtggg taaggttccc aagccagccc ccacaccctt cccacttggc acccagaggg   1200

ggctgtgggt cgaggcctga ctctaggcct ctcctgccca caccctctgg gctgagttcc   1260

ttctttccct tgaatgccca gtgctggcct tggaggatgg tcagctggag gacggcggtg   1320

ggggaggctg tctttgtacc actgcagcat cccccacttc tccacagaag ccccatccca   1380

aagctgctgc ccgacccctt gctgtaaaat gtgaaggggg tggctgagtt ctcttaggac   1440

ccagagccag ggccctcagc ttccatcctg cgggaggcct tggccgggca ctgccagcgt   1500

cttccagagc cacaccaggg accacgggag gatcctgacc cctgcagggc tcaggggtca   1560

gcacggaccc actgccccat ctccctctcc ccaccaagac agccccagaa ggagcagcca   1620

gctgggatgg gaacccaagg ctgcccacat gtggcttttg tgggactcag aaagggaagc   1680

agaaccgagg gctgggatat tactcatggt ggcagctctc atagtgcaag cctactgtaa   1740

tatgcaccca tctcatccat gtagtaaagt gaacttaaaa attaaatgaa caattaaata   1800

aacacctgtg tgtttaagac atgaaaa                                       1827


<210>  5262
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5262

Met Glu Leu Ser Lys Glu Ile Arg Glu Ala His Leu Ala Ala Leu Arg 
1               5                   10                  15      


Glu Arg Leu Arg Glu Glu Leu His Ala Ala Glu Val Arg Arg Asn Lys 
            20                  25                  30          


Glu Gln Arg Glu Glu Met Ser Gly 
        35                  40  


<210>  5263
<211>  1858
<212>  DNA
<213>  Homosapiens

<400>  5263
cgagcacgag cgggaggtgc tgcacaaggc gctggaggag aataacaact tcagccgcca     60

ggcggaggag aagctcaact acaaatggag ctcagcaagg agatccgcga ggcgcacctg    120

gccgcactgc gcgagcggct gcgcgaggag ctgcacgcgg ccgaggtgcg caggaacaag    180

gagcagcgag aggagatgtc gggctaaggg cccgggacgg gcggcgccca tcctgcgaga    240

gaacacgttc gggttttggt tttgtttcgt tcacctctgt ctagatgcaa cttttgttcc    300

tcctccccca cccccgcccc cagcttcatg cttctcttcc gcactcagcc gccctgccct    360

gtcctcgtgg tgagtcgctg accacggctt cccctgcagg agccgccggg cgtgagacgc    420

ggtccctcgg tgcagacacc aggccgggcg cggctgggtc ccccgggggc cctgtgagag    480

aggtggcggt gaccgtggta aacccagggc ggtggcgtgg gatcgcgggt ccttacgctg    540

ggctgtctgg tcagcacgtg caggtcaggg caggtcctct gagccggcgc ccctggccag    600

caggcgaggc tacagtacct gctgtctttc caggaggaag gggctcccca tgagggaggg    660

gcaacggggg aggcgggtga tggtgtctgg gagcctgcgt gtgcagccgg agcttgttga    720

actggcaggg ggtgggtggg ggctgcagct ttccttaatg tggttgcaca ggggtcctct    780

gagaccaccc ggcctgaggt ggacaccctg ggccttcctg gaagcctgca gttggggacc    840

tgccctgagt ctgctgggga gtgggcattc tctgccaggg acccatgagc aggctgcatg    900

gtctagaggt tgtgggcagc atggacagtc ccccactcag aagtgcaaga gttccaaaga    960

gcctctggcc caggcgcctc cgtgggacag ccccgccgcc cctccccacc agggctttgc   1020

agatgtcctt gaaagaccca ccctagagcc ctttggagtg ctggcccctc ctgtgtcctc   1080

tgccctggtg gaagtggcag ccacaagtcc tcctcaggga gccccaaggg ggattttgtg   1140

ggaccgctgc ccacagatcc aggtgttgga agggcagtgg gtaaggttcc caagccagcc   1200

cccacaccct tcccacttgg cacccagagg gggctgtggg tcgaggcctg actctaggcc   1260

tctcctgccc acaccctctg ggctgagttc cttctttccc ttgaatgccc agtgctggcc   1320

ttggaggatg gtcagctgga ggacggcggt gggggaggct gtctttgtac cactgcagca   1380

tcccccactt ctccacagaa gccccatccc aaagctgctg cccgacccct tgctgtaaaa   1440

tgtgaagggg gtggctgagt tctcttagga cccagagcca gggccctcag cttccatcct   1500

gcgggaggcc ttggccgggc actgccagcg tcttccagag ccacaccagg gaccacggga   1560

ggatcctgac ccctgcaggg ctcaggggtc agcacggacc cactgcccca tctccctctc   1620

cccaccaaga cagccccaga aggagcagcc agctgggatg ggaacccaag gctgcccaca   1680

tgtggctttt gtgggactca gaaagggaag cagaaccgag ggctgggata ttactcatgg   1740

tggcagctct catagtgcaa gcctactgta atatgcaccc atctcatcca tgtagtaaag   1800

tgaacttaaa aattaaatga acaattaaat aaacacctgt gtgtttaaga catgaaaa     1858


<210>  5264
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5264

Met Glu Leu Ser Lys Glu Ile Arg Glu Ala His Leu Ala Ala Leu Arg 
1               5                   10                  15      


Glu Arg Leu Arg Glu Glu Leu His Ala Ala Glu Val Arg Arg Asn Lys 
            20                  25                  30          


Glu Gln Arg Glu Glu Met Ser Gly 
        35                  40  


<210>  5265
<211>  467
<212>  DNA
<213>  Homosapiens

<400>  5265
taggcccagt acatgggctt atgtctgggg ccccagagga gtgagggcag caaagaacag     60

acaatgggct ccacgcagac ctctgcaaca cactggagcc tgagcccact gctgcaggac    120

ccatcaacaa caagaaggag ggagaaggtg tatgaccccc ctccctgcaa ctctcccatg    180

atctccatgg acacccaaag atatacactg cagcacccag caaagacgtg gtacttggtg    240

ttggagtgtg gatatgagtc atggaactct ggggctatat tgctgccagg ccctcaatgg    300

attggatggt gtccacctgc ataattgaag gtggatcttc tttactcagt cgactgattc    360

aaatgctgat ctcttccagc aacatcctca cagacacacc agaaataatg ttttaccagc    420

tatctgtgta tcccttagcc cagtaaaact gacacataca attaact                  467


<210>  5266
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  5266

Met Gly Leu Cys Leu Gly Pro Gln Arg Ser Glu Gly Ser Lys Glu Gln 
1               5                   10                  15      


Thr Met Gly Ser Thr Gln Thr Ser Ala Thr His Trp Ser Leu Ser Pro 
            20                  25                  30          


Leu Leu Gln Asp Pro Ser Thr Thr Arg Arg Arg Glu Lys Val Tyr Asp 
        35                  40                  45              


Pro Pro Pro Cys Asn Ser Pro Met Ile Ser Met Asp Thr Gln Arg Tyr 
    50                  55                  60                  


Thr Leu Gln His Pro Ala Lys Thr Trp Tyr Leu Val Leu Glu Cys Gly 
65                  70                  75                  80  


Tyr Glu Ser Trp Asn Ser Gly Ala Ile Leu Leu Pro Gly Pro Gln Trp 
                85                  90                  95      


Ile Gly Trp Cys Pro Pro Ala 
            100             


<210>  5267
<211>  467
<212>  DNA
<213>  Homosapiens

<400>  5267
taggcccagt ccatgggctt atgtctgggg ccccagagga gtgagggcag caaagaacag     60

acaatgggct ccacgcagac ctctgcaaca cactggagcc tgagcccaat gctgcaggac    120

ccatcaacaa caagaaggag ggagaaggtg tatgaccccc ctccctgcaa ctctcccatg    180

atctccatgg acacccaaag atatacactg cagcacccag caaagacgtg gtacttggtg    240

ttggaatatg gatatgagtc atggaactct ggggctatgt tgctgccagg ccctcaatgg    300

attggatggt gtccacctgc ataattgaag gtggatcttc tttactcagt cgactgattc    360

aaatgctgat ctcttccagc aacatcctca cagacacacc agaaataatg ttttaccagc    420

tatctgtgta tcccttagcc cagtaaaact gacacataca attaact                  467


<210>  5268
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  5268

Met Gly Leu Cys Leu Gly Pro Gln Arg Ser Glu Gly Ser Lys Glu Gln 
1               5                   10                  15      


Thr Met Gly Ser Thr Gln Thr Ser Ala Thr His Trp Ser Leu Ser Pro 
            20                  25                  30          


Met Leu Gln Asp Pro Ser Thr Thr Arg Arg Arg Glu Lys Val Tyr Asp 
        35                  40                  45              


Pro Pro Pro Cys Asn Ser Pro Met Ile Ser Met Asp Thr Gln Arg Tyr 
    50                  55                  60                  


Thr Leu Gln His Pro Ala Lys Thr Trp Tyr Leu Val Leu Glu Tyr Gly 
65                  70                  75                  80  


Tyr Glu Ser Trp Asn Ser Gly Ala Met Leu Leu Pro Gly Pro Gln Trp 
                85                  90                  95      


Ile Gly Trp Cys Pro Pro Ala 
            100             


<210>  5269
<211>  612
<212>  DNA
<213>  Homosapiens

<400>  5269
atgggcattg tgaggcactg ggggggctgt ggggctggac atgtcagctc cgactgtggc     60

tggcccaggg ggaaggcagc atccagttat gaatctgata tttatgaggc cgtggctgct    120

gcaacatcag aatccactac cgtagagcct ggcaagctgg atgtgggagc cacggagggc    180

caagacctgc agcacatcag caaccaaaag atgcccacag cttctgttct ggacctggaa    240

gatattgcgc ttgatattgc ggaggaggtg ttatctgaaa tgaactcaga ggacattgtt    300

gttagcctgg tgcccatcaa tctcactgga gacctcctgc atcgctacgt tagtccccct    360

gaggaccgcc tgagtttaaa acttctacca ccaagtgagg aagacaatga tgacaccaag    420

attttaccat cacctatcca ggcttctctt gaggacaacc tgactttagt atgcctacca    480

ccaagtgaag atgattgtga tgatgacaat gatgatgatg atgcccaggg atgcagaaaa    540

gaggcctcag agcagagtaa ggccgagtca gggctacaga gcccgatggc cacccctccc    600

ctgaacggct ag                                                        612


<210>  5270
<211>  203
<212>  PRT
<213>  Homosapiens

<400>  5270

Met Gly Ile Val Arg His Trp Gly Gly Cys Gly Ala Gly His Val Ser 
1               5                   10                  15      


Ser Asp Cys Gly Trp Pro Arg Gly Lys Ala Ala Ser Ser Tyr Glu Ser 
            20                  25                  30          


Asp Ile Tyr Glu Ala Val Ala Ala Ala Thr Ser Glu Ser Thr Thr Val 
        35                  40                  45              


Glu Pro Gly Lys Leu Asp Val Gly Ala Thr Glu Gly Gln Asp Leu Gln 
    50                  55                  60                  


His Ile Ser Asn Gln Lys Met Pro Thr Ala Ser Val Leu Asp Leu Glu 
65                  70                  75                  80  


Asp Ile Ala Leu Asp Ile Ala Glu Glu Val Leu Ser Glu Met Asn Ser 
                85                  90                  95      


Glu Asp Ile Val Val Ser Leu Val Pro Ile Asn Leu Thr Gly Asp Leu 
            100                 105                 110         


Leu His Arg Tyr Val Ser Pro Pro Glu Asp Arg Leu Ser Leu Lys Leu 
        115                 120                 125             


Leu Pro Pro Ser Glu Glu Asp Asn Asp Asp Thr Lys Ile Leu Pro Ser 
    130                 135                 140                 


Pro Ile Gln Ala Ser Leu Glu Asp Asn Leu Thr Leu Val Cys Leu Pro 
145                 150                 155                 160 


Pro Ser Glu Asp Asp Cys Asp Asp Asp Asn Asp Asp Asp Asp Ala Gln 
                165                 170                 175     


Gly Cys Arg Lys Glu Ala Ser Glu Gln Ser Lys Ala Glu Ser Gly Leu 
            180                 185                 190         


Gln Ser Pro Met Ala Thr Pro Pro Leu Asn Gly 
        195                 200             


<210>  5271
<211>  612
<212>  DNA
<213>  Homosapiens

<400>  5271
atgggcattg tgaggcactg ggggggctgt ggggctggac atgtcagctc cgactgtggc     60

tggcccaggg ggaaggcagc atccagttat gaatctgata tttatgaggc cgtggctgct    120

gcaacatcag aatccactac cgtagagcct ggcaagctgg atgtgggagc cacggagggc    180

caagacctgc agcacatcag caaccaaaag atgcccacag cttctgttct ggacctggaa    240

gatattgcgc ttgatattgc ggaggaggtg ttatctgaaa tgaactcaga ggacattgtt    300

gttagcctgg tgcccatcaa tctcactgga gacctcctgc atcgctacgt tagtccccct    360

gaggaccgcc tgagtttaaa acttctacca ccaagtgagg aagacaatga tgacaccaag    420

attttaccat cacctatcca ggcttctctt gaggacaacc tgactttagt atgcctacca    480

ccaagtgaag atgattgtga tgatgacaat gatgatgatg atgcccaggg atgcagaaaa    540

gaggcctcag agcagagtaa ggccgagtca gggctacaga gcccgatggc cacccctccc    600

ctgaacggct ag                                                        612


<210>  5272
<211>  203
<212>  PRT
<213>  Homosapiens

<400>  5272

Met Gly Ile Val Arg His Trp Gly Gly Cys Gly Ala Gly His Val Ser 
1               5                   10                  15      


Ser Asp Cys Gly Trp Pro Arg Gly Lys Ala Ala Ser Ser Tyr Glu Ser 
            20                  25                  30          


Asp Ile Tyr Glu Ala Val Ala Ala Ala Thr Ser Glu Ser Thr Thr Val 
        35                  40                  45              


Glu Pro Gly Lys Leu Asp Val Gly Ala Thr Glu Gly Gln Asp Leu Gln 
    50                  55                  60                  


His Ile Ser Asn Gln Lys Met Pro Thr Ala Ser Val Leu Asp Leu Glu 
65                  70                  75                  80  


Asp Ile Ala Leu Asp Ile Ala Glu Glu Val Leu Ser Glu Met Asn Ser 
                85                  90                  95      


Glu Asp Ile Val Val Ser Leu Val Pro Ile Asn Leu Thr Gly Asp Leu 
            100                 105                 110         


Leu His Arg Tyr Val Ser Pro Pro Glu Asp Arg Leu Ser Leu Lys Leu 
        115                 120                 125             


Leu Pro Pro Ser Glu Glu Asp Asn Asp Asp Thr Lys Ile Leu Pro Ser 
    130                 135                 140                 


Pro Ile Gln Ala Ser Leu Glu Asp Asn Leu Thr Leu Val Cys Leu Pro 
145                 150                 155                 160 


Pro Ser Glu Asp Asp Cys Asp Asp Asp Asn Asp Asp Asp Asp Ala Gln 
                165                 170                 175     


Gly Cys Arg Lys Glu Ala Ser Glu Gln Ser Lys Ala Glu Ser Gly Leu 
            180                 185                 190         


Gln Ser Pro Met Ala Thr Pro Pro Leu Asn Gly 
        195                 200             


<210>  5273
<211>  147
<212>  DNA
<213>  Homosapiens

<400>  5273
atggtggacc tggaggccgt ggtggccgat gtcagttacc tgatggccat ggagaagagc     60

aaggcgaccc cggccgacca cgcctgcaag aggaccgtcc tgcccgaacc cacgatgtgc    120

tactctttga tagacaatgc caagtag                                        147


<210>  5274
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  5274

Met Val Asp Leu Glu Ala Val Val Ala Asp Val Ser Tyr Leu Met Ala 
1               5                   10                  15      


Met Glu Lys Ser Lys Ala Thr Pro Ala Asp His Ala Cys Lys Arg Thr 
            20                  25                  30          


Val Leu Pro Glu Pro Thr Met Cys Tyr Ser Leu Ile Asp Asn Ala Lys 
        35                  40                  45              


<210>  5275
<211>  315
<212>  DNA
<213>  Homosapiens

<400>  5275
atgggcactg acctgtcccc caagcccaaa agcttcaatt acccattgct ctcgtcccca     60

ggtgatcagt ttgaaattca gctaacccag cagctatggt ccctcatccc caatgaggat    120

gtgagaaggt tcatgtctca tgttatctgg accttgaaaa tggaatgttc agaaacacat    180

gtgcaaggga cctgtgccaa gctcatgtca cgaacaggcc tcctgatgaa gcttctcagc    240

gagcagcagg aagcaaaggc atccaaggca gaatggtctg tagaccaatg gaaaactgat    300

gagactccat cttaa                                                     315


<210>  5276
<211>  104
<212>  PRT
<213>  Homosapiens

<400>  5276

Met Gly Thr Asp Leu Ser Pro Lys Pro Lys Ser Phe Asn Tyr Pro Leu 
1               5                   10                  15      


Leu Ser Ser Pro Gly Asp Gln Phe Glu Ile Gln Leu Thr Gln Gln Leu 
            20                  25                  30          


Trp Ser Leu Ile Pro Asn Glu Asp Val Arg Arg Phe Met Ser His Val 
        35                  40                  45              


Ile Trp Thr Leu Lys Met Glu Cys Ser Glu Thr His Val Gln Gly Thr 
    50                  55                  60                  


Cys Ala Lys Leu Met Ser Arg Thr Gly Leu Leu Met Lys Leu Leu Ser 
65                  70                  75                  80  


Glu Gln Gln Glu Ala Lys Ala Ser Lys Ala Glu Trp Ser Val Asp Gln 
                85                  90                  95      


Trp Lys Thr Asp Glu Thr Pro Ser 
            100                 


<210>  5277
<211>  315
<212>  DNA
<213>  Homosapiens

<400>  5277
atgggcactg acctgtcccc caagcccaaa agcttcaatt acccattgct ctcgtcccca     60

ggtgatcagt ttgaaattca gctaacccag cagctatggt ccctcatccc caatgaggat    120

gtgagaaggt tcatgtctca tgttatctgg accttgaaaa tggaatgttc agaaacacat    180

gtgcaaggga cctgtgccaa gctcatgtca cgaacaggcc tcctgatgaa gcttctccgc    240

gagcagcagg aagcaaaggc atccaaggca gaatggtctg tagaccaatg gaaaactgat    300

gagactccat cttaa                                                     315


<210>  5278
<211>  104
<212>  PRT
<213>  Homosapiens

<400>  5278

Met Gly Thr Asp Leu Ser Pro Lys Pro Lys Ser Phe Asn Tyr Pro Leu 
1               5                   10                  15      


Leu Ser Ser Pro Gly Asp Gln Phe Glu Ile Gln Leu Thr Gln Gln Leu 
            20                  25                  30          


Trp Ser Leu Ile Pro Asn Glu Asp Val Arg Arg Phe Met Ser His Val 
        35                  40                  45              


Ile Trp Thr Leu Lys Met Glu Cys Ser Glu Thr His Val Gln Gly Thr 
    50                  55                  60                  


Cys Ala Lys Leu Met Ser Arg Thr Gly Leu Leu Met Lys Leu Leu Arg 
65                  70                  75                  80  


Glu Gln Gln Glu Ala Lys Ala Ser Lys Ala Glu Trp Ser Val Asp Gln 
                85                  90                  95      


Trp Lys Thr Asp Glu Thr Pro Ser 
            100                 


<210>  5279
<211>  709
<212>  DNA
<213>  Homosapiens

<400>  5279
ccaccatgcc cagcctcatc attcttatta actggtttaa tcctttcaat aatcctatta     60

agtagaatta ttaggtaatt agaattaggt taaaaagagc tgaggtgtgg gtgttcgttt    120

ctcaggtgaa acatggctaa aagcttacgg agtaagtgga aaagaaagat gcgtgctgaa    180

aagagaaaaa agaatgcccc aaaggaggcc agcaggctta aaagtattct caaactagac    240

ggtgatgttt taatgaaaga tgttcaagag atagcaactg tggtggtacc caaacattgc    300

caagagaaaa tgcaatgtga ggtaaaagat gaaaaagatg acatgaaaag ggagactgat    360

actaagagaa acaaaaagac tcttctagac cagcatggac agtacccaat atggatgaac    420

caaaggcaaa gaaaaaggct gacggcaaag cgagagaaaa gaaaggggaa aagcaaagca    480

aaagcagtga aagtggcaaa gggtttggcg tggtagactc ttaaaacctt ggaaaatgcc    540

acatgggata gatgatggat tagaatgtat atacatgtat actttgattt cagctgccac    600

caaatgaaaa ccatttgttt tcctatttta acttggcctt ttttcttcaa ttcaaaccca    660

gcataactcc tgaagtttgt tttgggaact tgaataaaat attttcttt                709


<210>  5280
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  5280

Met Ala Lys Ser Leu Arg Ser Lys Trp Lys Arg Lys Met Arg Ala Glu 
1               5                   10                  15      


Lys Arg Lys Lys Asn Ala Pro Lys Glu Ala Ser Arg Leu Lys Ser Ile 
            20                  25                  30          


Leu Lys Leu Asp Gly Asp Val Leu Met Lys Asp Val Gln Glu Ile Ala 
        35                  40                  45              


Thr Val Val Val Pro Lys His Cys Gln Glu Lys Met Gln Cys Glu Val 
    50                  55                  60                  


Lys Asp Glu Lys Asp Asp Met Lys Arg Glu Thr Asp Thr Lys Arg Asn 
65                  70                  75                  80  


Lys Lys Thr Leu Leu Asp Gln His Gly Gln Tyr Pro Ile Trp Met Asn 
                85                  90                  95      


Gln Arg Gln Arg Lys Arg Leu Thr Ala Lys Arg Glu Lys Arg Lys Gly 
            100                 105                 110         


Lys Ser Lys Ala Lys Ala Val Lys Val Ala Lys Gly Leu Ala Trp 
        115                 120                 125         


<210>  5281
<211>  709
<212>  DNA
<213>  Homosapiens

<400>  5281
ccaccatgcc cagcctcatc attcttatta actggtttaa tcctttcaat aatcctatta     60

agtagaatta ttaggtaatt agaattaggt taaaaagagc tgaggtgtgg gtgttcgttt    120

ctcaggtaaa acatggctaa aagcttacgg agtaagtgga aaagaaagat gcgtgctgaa    180

aagagaaaaa agaatgcccc aaaggaggcc agcaggctta aaagtattct caaactagac    240

ggtgatgttt taatgaaaga tgttcaagag atagcaactg tggtggtacc caaacattgc    300

caagagaaaa tgcaatgtga ggtaaaagat gaaaaagatg acatgaaaat ggagactgat    360

actaagagaa acaaaaagac tcttctagac cagcatggac agtacccaat atggatgaac    420

caaaggcaaa gaaaaaggct gacggcaaag cgagagaaaa gaaaggggaa aagcaaagca    480

aaagcagtga aagtggcaaa gggtttggcg tggtagactc ttaaaacctt ggaaaatgcc    540

acatgggata gatgatggat tagaatgtat atacatgtat actttgattt cagctgccac    600

caaatgaaaa ccatttgttt tcctatttta acttggcctt ttttcttcaa ttcaaaccca    660

gcataactcc tgaagtttgt tttgggaact tgaataaaat attttcttt                709


<210>  5282
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  5282

Met Ala Lys Ser Leu Arg Ser Lys Trp Lys Arg Lys Met Arg Ala Glu 
1               5                   10                  15      


Lys Arg Lys Lys Asn Ala Pro Lys Glu Ala Ser Arg Leu Lys Ser Ile 
            20                  25                  30          


Leu Lys Leu Asp Gly Asp Val Leu Met Lys Asp Val Gln Glu Ile Ala 
        35                  40                  45              


Thr Val Val Val Pro Lys His Cys Gln Glu Lys Met Gln Cys Glu Val 
    50                  55                  60                  


Lys Asp Glu Lys Asp Asp Met Lys Met Glu Thr Asp Thr Lys Arg Asn 
65                  70                  75                  80  


Lys Lys Thr Leu Leu Asp Gln His Gly Gln Tyr Pro Ile Trp Met Asn 
                85                  90                  95      


Gln Arg Gln Arg Lys Arg Leu Thr Ala Lys Arg Glu Lys Arg Lys Gly 
            100                 105                 110         


Lys Ser Lys Ala Lys Ala Val Lys Val Ala Lys Gly Leu Ala Trp 
        115                 120                 125         


<210>  5283
<211>  699
<212>  DNA
<213>  Homosapiens

<400>  5283
atgggagaga accaagaaca gttaagatgt aaaattgatg cagagaccca aacacctgag     60

tgggagaacc aggataagaa tggaagtgag gatgctgtgg agacccagac atttgagaag    120

aaggacaaga aagaggctgg agaggaggat ggggaagaga tccaggctca aggattgggg    180

aagcaaggcc agactggaga tgagaatggt gaggagaccc agacaccaca gtgggagaaa    240

caagatcaga tgaaaggtga tgcggatgtg gaaattcaga tggaagaggg gagaaacaag    300

gatcaggttg gaggtcagga tgctgcacaa acccaatcat gtgggaggga gaacgtggga    360

gaagtaaaaa aagagaatag tgtagagacc caggccttgg attggggaaa acaggaatgt    420

gttggaaatg ggaatgttac agagatccag acaccaaggt gggagaagca tgatcaaggt    480

ggaagtaaga aagctaagaa gacccaagca tctgggggag agaaccagaa acaattaagt    540

catgaaattc aagtggggtg gggaaataag ggcctgagaa gagatgaaga tgctaaggaa    600

acccagatag ctaccaagaa gaagctcagg gagataagag aaggattggg tggtgatcca    660

ggcactatgg tggggaaacc ggagacaagt agcaagtga                           699


<210>  5284
<211>  232
<212>  PRT
<213>  Homosapiens

<400>  5284

Met Gly Glu Asn Gln Glu Gln Leu Arg Cys Lys Ile Asp Ala Glu Thr 
1               5                   10                  15      


Gln Thr Pro Glu Trp Glu Asn Gln Asp Lys Asn Gly Ser Glu Asp Ala 
            20                  25                  30          


Val Glu Thr Gln Thr Phe Glu Lys Lys Asp Lys Lys Glu Ala Gly Glu 
        35                  40                  45              


Glu Asp Gly Glu Glu Ile Gln Ala Gln Gly Leu Gly Lys Gln Gly Gln 
    50                  55                  60                  


Thr Gly Asp Glu Asn Gly Glu Glu Thr Gln Thr Pro Gln Trp Glu Lys 
65                  70                  75                  80  


Gln Asp Gln Met Lys Gly Asp Ala Asp Val Glu Ile Gln Met Glu Glu 
                85                  90                  95      


Gly Arg Asn Lys Asp Gln Val Gly Gly Gln Asp Ala Ala Gln Thr Gln 
            100                 105                 110         


Ser Cys Gly Arg Glu Asn Val Gly Glu Val Lys Lys Glu Asn Ser Val 
        115                 120                 125             


Glu Thr Gln Ala Leu Asp Trp Gly Lys Gln Glu Cys Val Gly Asn Gly 
    130                 135                 140                 


Asn Val Thr Glu Ile Gln Thr Pro Arg Trp Glu Lys His Asp Gln Gly 
145                 150                 155                 160 


Gly Ser Lys Lys Ala Lys Lys Thr Gln Ala Ser Gly Gly Glu Asn Gln 
                165                 170                 175     


Lys Gln Leu Ser His Glu Ile Gln Val Gly Trp Gly Asn Lys Gly Leu 
            180                 185                 190         


Arg Arg Asp Glu Asp Ala Lys Glu Thr Gln Ile Ala Thr Lys Lys Lys 
        195                 200                 205             


Leu Arg Glu Ile Arg Glu Gly Leu Gly Gly Asp Pro Gly Thr Met Val 
    210                 215                 220                 


Gly Lys Pro Glu Thr Ser Ser Lys 
225                 230         


<210>  5285
<211>  390
<212>  DNA
<213>  Homosapiens

<400>  5285
atgcacctgt gtttctgcct aagctctcta agcgtgacag caggagcgcc cgggtctcca     60

tcccggagag atgtgtccac actccgccgc cactgctctc ttcatcagca acttgcttct    120

gcagtcgctg cccaaagttt cgcggagcac ccggcgacct ggccgtcggt caatcctgag    180

aagcccaggg attcggggcg cggagactgg gggctgggcc ccgggaatcc caaagacgtc    240

cccgcggcca ggaagggagt gacaggtgcg acgcgcggtc gcgggcggcg ggagagcgga    300

ccacggaaac cgcgtgtggg cgcgcgaggg aggcggcggc cacgcgctct ccttaggccg    360

ctccctgaga cgcccccgcg acgtccctag                                     390


<210>  5286
<211>  129
<212>  PRT
<213>  Homosapiens

<400>  5286

Met His Leu Cys Phe Cys Leu Ser Ser Leu Ser Val Thr Ala Gly Ala 
1               5                   10                  15      


Pro Gly Ser Pro Ser Arg Arg Asp Val Ser Thr Leu Arg Arg His Cys 
            20                  25                  30          


Ser Leu His Gln Gln Leu Ala Ser Ala Val Ala Ala Gln Ser Phe Ala 
        35                  40                  45              


Glu His Pro Ala Thr Trp Pro Ser Val Asn Pro Glu Lys Pro Arg Asp 
    50                  55                  60                  


Ser Gly Arg Gly Asp Trp Gly Leu Gly Pro Gly Asn Pro Lys Asp Val 
65                  70                  75                  80  


Pro Ala Ala Arg Lys Gly Val Thr Gly Ala Thr Arg Gly Arg Gly Arg 
                85                  90                  95      


Arg Glu Ser Gly Pro Arg Lys Pro Arg Val Gly Ala Arg Gly Arg Arg 
            100                 105                 110         


Arg Pro Arg Ala Leu Leu Arg Pro Leu Pro Glu Thr Pro Pro Arg Arg 
        115                 120                 125             


Pro 
    


<210>  5287
<211>  1571
<212>  DNA
<213>  Homosapiens

<400>  5287
tgagtagctg gaactacagg caagtgccac catggggatc tggccatgtt gcccaggtgg     60

gtcgtaaact cctggcctca agcagccctc ctgcttcagc ctcctgagta gctgggacta    120

ccgctgcaca ccagcaggcc ctgccaattg actgctttta cagtgagtgc acccagggcg    180

gccgcagatg gcagtgtctc tggggacagc agctgcgaat gagtccacgg gccaatgctg    240

agctgctcag gctgaggcgg tgtgctcagc acagagcccc cggaactggc atctgcaggg    300

cgtgagccaa ggccgccgcg atgccgcact tcctggactg gttcgtgccg gtctacttgg    360

tcatctcggt cctcattctg gtgggcttcg gcgcctgcat ctactacttc gagccgggcc    420

tgcaggaggc gcacaagtgg cgcatgcagc gccccctggt ggaccgcgac ctccgcaaga    480

cgctaatggt gcgcgacaac ctggccttcg gcggcccgga ggtctgagcc gacttgcaaa    540

ggggataggc gggcggcacc gggcgccctc ccccagcccg ccccgcccgc ccagcccgga    600

gacccccaag gcagagggag gccggcctgt tggccctcca cgctatccct ctgcagcctg    660

ggccctcccg acagaggccc caggtgcgct ggcagtggag gtggggcact taggtgcctg    720

gctggcccag ggcttgctct ccgtgtcaag ccgactcacc cagagcccac cctcccaagc    780

tcaggggcat cctccgctgg gccccagtgc ctttgcgctg cgcagcactc tgccctccac    840

tggactcagg catgtctatg gctgcctgtc ctgaggctcc ggagccctca tttcttcgtg    900

aagtccccag ctcccctgcc tccactcaat ggcaccggcc ctgcaacttt aggcaggtcg    960

aagccaaccc aaggaaagaa cctaagaacc tcgtttggag ggatgtcagc ttgggccaga   1020

ccagccgcac cccgcggggc tcaggcttgg aactggtgag ggtgtgtggt gggggtatgc   1080

agagggataa gaccgtggta gaggagaggg ttggtgagga gagagagaga gagagagaga   1140

gagtctgggg ggagcgggca agcatgggga gatgagatgt gtatatgtga gagagagtgt   1200

gggggcccca ggcagggcag gaggtggtgg aaacggggtg aactccgtgg gctgtgtgag   1260

gactgtccat agtgggtccc aaccccctcc ctctgctgga gtttcctagc ccttccccct   1320

ccccaagact gtggcagcag gcaggagccc ctgccctccc tccctgtcct gtgccacact   1380

tctggggcca aacccagccc ccttgagcca ggccctgcca gactccaagc ccaccctaga   1440

accctcctcc tgtgtggaga ctctgttgcc ccactttgga cacagattgg caacctgcct   1500

caccccgccc cccttcgctg gggcttccat cttaatttat tctcaataat aaagacttca   1560

tgatgatctc t                                                        1571


<210>  5288
<211>  68
<212>  PRT
<213>  Homosapiens

<400>  5288

Met Pro His Phe Leu Asp Trp Phe Val Pro Val Tyr Leu Val Ile Ser 
1               5                   10                  15      


Val Leu Ile Leu Val Gly Phe Gly Ala Cys Ile Tyr Tyr Phe Glu Pro 
            20                  25                  30          


Gly Leu Gln Glu Ala His Lys Trp Arg Met Gln Arg Pro Leu Val Asp 
        35                  40                  45              


Arg Asp Leu Arg Lys Thr Leu Met Val Arg Asp Asn Leu Ala Phe Gly 
    50                  55                  60                  


Gly Pro Glu Val 
65              


<210>  5289
<211>  1494
<212>  DNA
<213>  Homosapiens

<400>  5289
ggactgcccc ctcctggccc actcagagcc cctgggtgtg agaagctcgt ctcccgtggg     60

ttgcattggc tctgccctat ctctgcctcc agcacccagg gcggccgcag atggcagtgt    120

ctctggggac agcagctgcg aatgagtcca cgggccaatg ctgagctgct caggctgagg    180

cggtgtgctc agcacagagc ccccggaact ggcatctgca gggcgtgagc caaggccgcc    240

gcgatgccgc acttcctgga ctggttcgtg ccggtctact tggtcatctc ggtcctcatt    300

ctggtgggct tcggcgcctg catctactac ttcgagccgg gcctgcagga ggcgcacaag    360

tggcgcatgc agcgccccct ggtggaccgc gacctccgca agacgctaat ggtgcgcgac    420

aacctggcct tcggcggccc ggaggtctga gccgacttgc aaaggggata ggcgggcggc    480

accgggcgcc ctcccccagc ccgccccgcc cgcccagccc ggagaccccc aaggcagagg    540

gaggccggcc tgttggccct ccacgctatc cctctgcagc ctgggccctc ccgacagagg    600

ccccaggtgc gctggcagtg gaggtggggc acttaggtgc ctggctggcc cagggcttgc    660

tctccgtgtc aagccgactc acccagagcc caccctccca agctcagggg catcctccgc    720

tgggccccag tgcctttgcg ctgcgcagca ctctgccctc cactggactc aggcatgtct    780

atggctgcct gtcctgaggc tccggagccc tcatttcttc gtgaagtccc cagctcccct    840

gcctccactc aatggcaccg gccctgcaac tttaggcagg tcgaagccaa cccaaggaaa    900

gaacctaaga acctcgtttg gagggatgtc agcttgggcc agaccagccg caccccgcgg    960

ggctcaggct tggaactggt gagggtgtgt ggtgggggta tgcagaggga taagaccgtg   1020

gtagaggaga gggttggtga ggagagagag agagagagag agagagtctg gggggagcgg   1080

gcaagcatgg ggagatgaga tgtgtatatg tgagagagag tgtgggggcc ccaggcaggg   1140

caggaggtgg tggaaacggg gtgaactccg tgggctgtgt gaggactgtc catagtgggt   1200

cccaaccccc tccctctgct ggagtttcct agcccttccc cctccccaag actgtggcag   1260

caggcaggag cccctgccct ccctccctgt cctgtgccac acttctgggg ccaaacccag   1320

cccccttgag ccaggccctg ccagactcca agcccaccct agaaccctcc tcctgtgtgg   1380

agactctgtt gccccacttt ggacacagat tggcaacctg cctcaccccg ccccccttcg   1440

ctggggcttc catcttaatt tattctcaat aataaagact tcatgatgat ctct         1494


<210>  5290
<211>  68
<212>  PRT
<213>  Homosapiens

<400>  5290

Met Pro His Phe Leu Asp Trp Phe Val Pro Val Tyr Leu Val Ile Ser 
1               5                   10                  15      


Val Leu Ile Leu Val Gly Phe Gly Ala Cys Ile Tyr Tyr Phe Glu Pro 
            20                  25                  30          


Gly Leu Gln Glu Ala His Lys Trp Arg Met Gln Arg Pro Leu Val Asp 
        35                  40                  45              


Arg Asp Leu Arg Lys Thr Leu Met Val Arg Asp Asn Leu Ala Phe Gly 
    50                  55                  60                  


Gly Pro Glu Val 
65              


<210>  5291
<211>  974
<212>  DNA
<213>  Homosapiens

<400>  5291
ggagaccccc aaggcagagg gaggccggcc tgttggccct ccacgctatc cctctgcagc     60

ctgggccctc ccgacagagg ccccaggtgc gctggcagtg gaggtggggc acttaggtgc    120

ctggctggcc cagggcttgc tctccgtgtc aagccgactc acccagagcc caccctccca    180

agctcagggg catcctccgc tgggccccag tgcctttgcg ctgcgcagca ctctgccctc    240

cactggactc aggcatgtct atggctgcct gtcctgaggc tccggagccc tcatttcttc    300

gtgaagtccc cagctcccct gcctccactc aatggcaccg gccctgcaac tttaggcagg    360

tcgaagccaa cccaaggaaa gaacctaaga acctcgtttg gagggatgtc agcttgggcc    420

agaccagccg caccccgcgg ggctcaggct tggaactggt gagggtgtgt ggtgggggta    480

tgcagaggga taagaccgtg gtagaggaga gggttggtga ggagagagag agagagagag    540

agagagtctg gggggagcgg gcaagcatgg ggagatgaga tgtgtatatg tgagagagag    600

tgtgggggcc ccaggcaggg caggaggtgg tggaaacggg gtgaactccg tgggctgtgt    660

gaggactgtc catagtgggt cccaaccccc tccctctgct ggagtttcct agcccttccc    720

cctccccaag actgtggcag caggcaggag cccctgccct ccctccctgt cctgtgccac    780

acttctgggg ccaaacccag cccccttgag ccaggccctg ccagactcca agcccaccct    840

agaaccctcc tcctgtgtgg agactctgtt gccccacttt ggacacagat tggcaacctg    900

cctcaccccg ccccccttcg ctggggcttc catcttaatt tattctcaat aataaagact    960

tcatgatgat ctct                                                      974


<210>  5292
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  5292

Met Ser Met Ala Ala Cys Pro Glu Ala Pro Glu Pro Ser Phe Leu Arg 
1               5                   10                  15      


Glu Val Pro Ser Ser Pro Ala Ser Thr Gln Trp His Arg Pro Cys Asn 
            20                  25                  30          


Phe Arg Gln Val Glu Ala Asn Pro Arg Lys Glu Pro Lys Asn Leu Val 
        35                  40                  45              


Trp Arg Asp Val Ser Leu Gly Gln Thr Ser Arg Thr Pro Arg Gly Ser 
    50                  55                  60                  


Gly Leu Glu Leu Val Arg Val Cys Gly Gly Gly Met Gln Arg Asp Lys 
65                  70                  75                  80  


Thr Val Val Glu Glu Arg Val Gly Glu Glu Arg Glu Arg Glu Arg Glu 
                85                  90                  95      


Arg Val Trp Gly Glu Arg Ala Ser Met Gly Arg 
            100                 105         


<210>  5293
<211>  1344
<212>  DNA
<213>  Homosapiens

<400>  5293
atggaccaca actttgctcc tgctcctcca gagatgcagt cgcatggagc tccaggcccg     60

ggaacctcct tctcccatag ccatgtgctg gggcgcccta tccgcccctc gagactccct    120

ggaggagggt cccccctcac ccccgtcctc aggaagacca tccatctgga taccttcccc    180

caaagccata tcccacagac ctccagccgg ctgggccttg gagccaggac ccggagtgtg    240

cccccacagg agacgggcat cgctctgggg gcttccttga gccccctgcc caccagcagc    300

cttgtaccca ggaagctcag ctccatctcc ttgactctcc atcagaacag ccaggcacgg    360

tccctggatc gcccactttc tcactgggaa gagttgccta ccccaggaaa gaaggctgct    420

ccccatgaag gagggagggt gtcctcgcca ggctcgccac ctgtgaccct agtgccaggg    480

ggcagggtcc actctgaggg cccagggaac ccaggtctga ccaaatccaa caggatgctt    540

gccacggaga agcccctggt gagttcctac ctagccttac ctttccaatc ccggttagcc    600

cagagtgcac cagtccttgc agagccaggc tcgttgggcc aggggcacct tgtctcagtg    660

actgaccaca tgcctaccag agcttctcca ggaaaaggca agccccgggc cagggggatc    720

cccagacccc gggggcgtct ccaaagggcc aacacgactg tgaatttgac tgctatggac    780

acaaggacag acgcagccag acatttagcc acaatggcca ccaacagacc tagcttggct    840

atcaatttag ccacaccaaa cacatcccaa ctggacacag gcacagagtt ccctgccctg    900

gatatcaagc tgggcacagc cagagacttg tcttcggtag ggacagtcaa gtcaggcaaa    960

accgtgaact tggctacagc aggcacaatc aagccgggca cagccatgaa tctgactaca   1020

gttgggacaa ccaagccagg gatggtcatg gatttgatag cctcagaacc agacaagctg   1080

ggcaaagcca tggctacaag aagcacagcc aaaccagata tgaccacaga gggtatagcc   1140

atggattcag caacatcaga cccagtcaag ccggacacaa tcacagctac agtgggcacc   1200

aaatacctct ccctttccat tcttcccttc cactcccatt tgcctttcca tctggccctc   1260

atctcctcca agaagtcttc caagccccct ctccccagga cccagaacct tcgaggggag   1320

ggatggttgt cctcacccct gtga                                          1344


<210>  5294
<211>  447
<212>  PRT
<213>  Homosapiens

<400>  5294

Met Asp His Asn Phe Ala Pro Ala Pro Pro Glu Met Gln Ser His Gly 
1               5                   10                  15      


Ala Pro Gly Pro Gly Thr Ser Phe Ser His Ser His Val Leu Gly Arg 
            20                  25                  30          


Pro Ile Arg Pro Ser Arg Leu Pro Gly Gly Gly Ser Pro Leu Thr Pro 
        35                  40                  45              


Val Leu Arg Lys Thr Ile His Leu Asp Thr Phe Pro Gln Ser His Ile 
    50                  55                  60                  


Pro Gln Thr Ser Ser Arg Leu Gly Leu Gly Ala Arg Thr Arg Ser Val 
65                  70                  75                  80  


Pro Pro Gln Glu Thr Gly Ile Ala Leu Gly Ala Ser Leu Ser Pro Leu 
                85                  90                  95      


Pro Thr Ser Ser Leu Val Pro Arg Lys Leu Ser Ser Ile Ser Leu Thr 
            100                 105                 110         


Leu His Gln Asn Ser Gln Ala Arg Ser Leu Asp Arg Pro Leu Ser His 
        115                 120                 125             


Trp Glu Glu Leu Pro Thr Pro Gly Lys Lys Ala Ala Pro His Glu Gly 
    130                 135                 140                 


Gly Arg Val Ser Ser Pro Gly Ser Pro Pro Val Thr Leu Val Pro Gly 
145                 150                 155                 160 


Gly Arg Val His Ser Glu Gly Pro Gly Asn Pro Gly Leu Thr Lys Ser 
                165                 170                 175     


Asn Arg Met Leu Ala Thr Glu Lys Pro Leu Val Ser Ser Tyr Leu Ala 
            180                 185                 190         


Leu Pro Phe Gln Ser Arg Leu Ala Gln Ser Ala Pro Val Leu Ala Glu 
        195                 200                 205             


Pro Gly Ser Leu Gly Gln Gly His Leu Val Ser Val Thr Asp His Met 
    210                 215                 220                 


Pro Thr Arg Ala Ser Pro Gly Lys Gly Lys Pro Arg Ala Arg Gly Ile 
225                 230                 235                 240 


Pro Arg Pro Arg Gly Arg Leu Gln Arg Ala Asn Thr Thr Val Asn Leu 
                245                 250                 255     


Thr Ala Met Asp Thr Arg Thr Asp Ala Ala Arg His Leu Ala Thr Met 
            260                 265                 270         


Ala Thr Asn Arg Pro Ser Leu Ala Ile Asn Leu Ala Thr Pro Asn Thr 
        275                 280                 285             


Ser Gln Leu Asp Thr Gly Thr Glu Phe Pro Ala Leu Asp Ile Lys Leu 
    290                 295                 300                 


Gly Thr Ala Arg Asp Leu Ser Ser Val Gly Thr Val Lys Ser Gly Lys 
305                 310                 315                 320 


Thr Val Asn Leu Ala Thr Ala Gly Thr Ile Lys Pro Gly Thr Ala Met 
                325                 330                 335     


Asn Leu Thr Thr Val Gly Thr Thr Lys Pro Gly Met Val Met Asp Leu 
            340                 345                 350         


Ile Ala Ser Glu Pro Asp Lys Leu Gly Lys Ala Met Ala Thr Arg Ser 
        355                 360                 365             


Thr Ala Lys Pro Asp Met Thr Thr Glu Gly Ile Ala Met Asp Ser Ala 
    370                 375                 380                 


Thr Ser Asp Pro Val Lys Pro Asp Thr Ile Thr Ala Thr Val Gly Thr 
385                 390                 395                 400 


Lys Tyr Leu Ser Leu Ser Ile Leu Pro Phe His Ser His Leu Pro Phe 
                405                 410                 415     


His Leu Ala Leu Ile Ser Ser Lys Lys Ser Ser Lys Pro Pro Leu Pro 
            420                 425                 430         


Arg Thr Gln Asn Leu Arg Gly Glu Gly Trp Leu Ser Ser Pro Leu 
        435                 440                 445         


<210>  5295
<211>  636
<212>  DNA
<213>  Homosapiens

<400>  5295
atgtggcgct ctaggtggga tgccagcgtc ctgaaggcgg aggccctggc cctcctcccc     60

tgcggcctgg gcatggcatt ctcccagtcc cacgtgatgg ccgctcggcg gcaccagcac    120

agccggctca tcatcgaggt ggacgagtac agctccaacc ccacccaggc cttcaccttc    180

tacaacatca accagggccg cttccagcca ccgcatgtgc agatggtgga cccggtgcct    240

cacgatgccc ccaaacctcc aggctacacc cgcttcgtct gcgtctctga tacccactcg    300

aggacggacc ccatccagat gccgtacggc gacgtgctga tccacgctgg ggacttcact    360

gagctggggc tcccgagcga ggtgaagaag ttcaacgagt ggctgggcag cctgccctac    420

gagtacaaga tcgtgatcgc aggcaaccac gagctgacct ttgaccagga gttcatggcc    480

gacctcatca agcaggactt ttactacttc ccatctgtgt cgaagctgaa gccggagaac    540

tatgagaatg tgcagtcgct gctgaccaac tgcatctacc ttcaggactc ggaggtcacc    600

gtgcggggct tccggatcta tggctcccca tggtga                              636


<210>  5296
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  5296

Met Trp Arg Ser Arg Trp Asp Ala Ser Val Leu Lys Ala Glu Ala Leu 
1               5                   10                  15      


Ala Leu Leu Pro Cys Gly Leu Gly Met Ala Phe Ser Gln Ser His Val 
            20                  25                  30          


Met Ala Ala Arg Arg His Gln His Ser Arg Leu Ile Ile Glu Val Asp 
        35                  40                  45              


Glu Tyr Ser Ser Asn Pro Thr Gln Ala Phe Thr Phe Tyr Asn Ile Asn 
    50                  55                  60                  


Gln Gly Arg Phe Gln Pro Pro His Val Gln Met Val Asp Pro Val Pro 
65                  70                  75                  80  


His Asp Ala Pro Lys Pro Pro Gly Tyr Thr Arg Phe Val Cys Val Ser 
                85                  90                  95      


Asp Thr His Ser Arg Thr Asp Pro Ile Gln Met Pro Tyr Gly Asp Val 
            100                 105                 110         


Leu Ile His Ala Gly Asp Phe Thr Glu Leu Gly Leu Pro Ser Glu Val 
        115                 120                 125             


Lys Lys Phe Asn Glu Trp Leu Gly Ser Leu Pro Tyr Glu Tyr Lys Ile 
    130                 135                 140                 


Val Ile Ala Gly Asn His Glu Leu Thr Phe Asp Gln Glu Phe Met Ala 
145                 150                 155                 160 


Asp Leu Ile Lys Gln Asp Phe Tyr Tyr Phe Pro Ser Val Ser Lys Leu 
                165                 170                 175     


Lys Pro Glu Asn Tyr Glu Asn Val Gln Ser Leu Leu Thr Asn Cys Ile 
            180                 185                 190         


Tyr Leu Gln Asp Ser Glu Val Thr Val Arg Gly Phe Arg Ile Tyr Gly 
        195                 200                 205             


Ser Pro Trp 
    210     


<210>  5297
<211>  1004
<212>  DNA
<213>  Homosapiens

<400>  5297
atgtggatgc tgggagaagt atgtgagatg gaaaagttgt ttcatggcat ccaagaagtg     60

aatgatcctc aaggtgtagc agaggaatct gtaggagaga gggatgattg acgtcttcgt    120

atagccctcc atccatccca gttagcatgg agggatttta gggctaccat tggctgggta    180

gtggagtgtt gaccaatcac agctcagggg cgtgattgtc tcgtcctggg atcgcgagag    240

gtgtatatac agggaggcca ggcagcctgg agttagtcga ccgttgcgag acgttgagct    300

gcggaagatg agtccaaagc cgagagcctc gggacctccg gccaaggcca cggaggcagg    360

aaagaggaag tcctcctctc agccgagccc cagtgacccg aagaagaaga ctaccaaggt    420

ggccaagaag ggaaaagcag ttcgtagagg gagacgcggg aagaaagggg ctgcgacaaa    480

gatggcggcc gtgacggcac ctgaggcgga gagcgggcca gcggcacccg gccccagcga    540

ccagcccagc caggagctcc ctcagcacga gctgccgccg gaggagccag tgagcgaggg    600

gacccagcac gaccccctga gtcaggagag cgagctggag gaaccactga gtcaggagag    660

cgaggtggaa gaaccactga gtcaggagag ccaggtggag gaaccactga gtcaggagag    720

cgaggtggaa gaaccactga gtcaggagag ccaggtggag gaaccactga gtcaggagag    780

cgaggtggag gaaccactga gtcaggagag ccaggtggag gaaccactga gtcaggagag    840

cgagatggaa gaactaccga gtgtgtagac ggccagctac tcccctatct ccgagagcag    900

cgactaagtt caggcccagc cgccagacct cagagatctc accagcgggg tgcttgccat    960

tctgaagata ataaaatgaa tgtgttgcaa attgaaaaaa aaaa                    1004


<210>  5298
<211>  186
<212>  PRT
<213>  Homosapiens

<400>  5298

Met Ser Pro Lys Pro Arg Ala Ser Gly Pro Pro Ala Lys Ala Thr Glu 
1               5                   10                  15      


Ala Gly Lys Arg Lys Ser Ser Ser Gln Pro Ser Pro Ser Asp Pro Lys 
            20                  25                  30          


Lys Lys Thr Thr Lys Val Ala Lys Lys Gly Lys Ala Val Arg Arg Gly 
        35                  40                  45              


Arg Arg Gly Lys Lys Gly Ala Ala Thr Lys Met Ala Ala Val Thr Ala 
    50                  55                  60                  


Pro Glu Ala Glu Ser Gly Pro Ala Ala Pro Gly Pro Ser Asp Gln Pro 
65                  70                  75                  80  


Ser Gln Glu Leu Pro Gln His Glu Leu Pro Pro Glu Glu Pro Val Ser 
                85                  90                  95      


Glu Gly Thr Gln His Asp Pro Leu Ser Gln Glu Ser Glu Leu Glu Glu 
            100                 105                 110         


Pro Leu Ser Gln Glu Ser Glu Val Glu Glu Pro Leu Ser Gln Glu Ser 
        115                 120                 125             


Gln Val Glu Glu Pro Leu Ser Gln Glu Ser Glu Val Glu Glu Pro Leu 
    130                 135                 140                 


Ser Gln Glu Ser Gln Val Glu Glu Pro Leu Ser Gln Glu Ser Glu Val 
145                 150                 155                 160 


Glu Glu Pro Leu Ser Gln Glu Ser Gln Val Glu Glu Pro Leu Ser Gln 
                165                 170                 175     


Glu Ser Glu Met Glu Glu Leu Pro Ser Val 
            180                 185     


<210>  5299
<211>  339
<212>  DNA
<213>  Homosapiens

<400>  5299
atgcagccag attgctcctt taagtgggtc cctgatctca ttcctcctga actgggacca     60

gtcattccag atagtggtta ttcatcatcc cacgcagagg ccacctatga agaaggcttg    120

gaagtatttg acccctatta tttcatcaaa catgtcccac cactgacaga agaacaacta    180

aataggaaat ctgttcttcc gttgaaaaca agaagcacac cgaaattctc cctagattta    240

cacttggatg aaacagtagt gcactgtagt ctaaatgagg tagaagaggc agcacttact    300

tttccagtcc ttttccaaga tgtcatttat caggtttag                           339


<210>  5300
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  5300

Met Gln Pro Asp Cys Ser Phe Lys Trp Val Pro Asp Leu Ile Pro Pro 
1               5                   10                  15      


Glu Leu Gly Pro Val Ile Pro Asp Ser Gly Tyr Ser Ser Ser His Ala 
            20                  25                  30          


Glu Ala Thr Tyr Glu Glu Gly Leu Glu Val Phe Asp Pro Tyr Tyr Phe 
        35                  40                  45              


Ile Lys His Val Pro Pro Leu Thr Glu Glu Gln Leu Asn Arg Lys Ser 
    50                  55                  60                  


Val Leu Pro Leu Lys Thr Arg Ser Thr Pro Lys Phe Ser Leu Asp Leu 
65                  70                  75                  80  


His Leu Asp Glu Thr Val Val His Cys Ser Leu Asn Glu Val Glu Glu 
                85                  90                  95      


Ala Ala Leu Thr Phe Pro Val Leu Phe Gln Asp Val Ile Tyr Gln Val 
            100                 105                 110         


<210>  5301
<211>  763
<212>  DNA
<213>  Homosapiens

<400>  5301
gagcgcgtgc accctagtct cttcctctta cttttatttt attatttttt tgagatagtg     60

tctcattctg tcgcccaggc tggagtgccg tggtgtgatc acagctcact gcagtctcaa    120

ccttcctggc tcaagcgatc ctcccacctc agcctcccga gtagctgaga ctacaggcac    180

ttgccaccac acccggctaa ttaaattttt tgttttgttt tcttttaggg ctggggtgtc    240

actatgttgc ccaggctgct ctagaactcc tgggctcaag tgatcctcct gcctctgcct    300

tccaaagtgt tgggattaca ggcatgaacc accatggcta gtttaaatgg tttttcaggg    360

tcacatatct cggaagatat gtgggatgta aacccagcag cctggcccca gagcccatgg    420

tcttcatggc agcagcatgt gtgccgcctc tcatgtgtac aagtgaatga agaatgaaag    480

agagttgcac tctcaccaat gaccagctgc cttctgggtg aagtgaaaca ataccgagaa    540

acaaggaggc ctggtcctac caggccacaa agctgcttga ctgtctgcct aggggaaaag    600

gaattcggcc acatggagaa gaggacaaag atactcagag agaaaaagta aaagaccgaa    660

gaaggaggct ggagagacca ggatccttcc agctgaacaa agtcagccac aaagcagact    720

agccagccgg ctacaattgg agtcagagtc ccaaagacat ggg                      763


<210>  5302
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  5302

Met Thr Ser Cys Leu Leu Gly Glu Val Lys Gln Tyr Arg Glu Thr Arg 
1               5                   10                  15      


Arg Pro Gly Pro Thr Arg Pro Gln Ser Cys Leu Thr Val Cys Leu Gly 
            20                  25                  30          


Glu Lys Glu Phe Gly His Met Glu Lys Arg Thr Lys Ile Leu Arg Glu 
        35                  40                  45              


Lys Lys 
    50  


<210>  5303
<211>  763
<212>  DNA
<213>  Homosapiens

<400>  5303
gagcgcgtgc accctagtct cttcctctta cttttatttt attatttttt tgagatagtg     60

tctcattctg tcgcccaggc tggagtgccg tggtgtgatc acagctcact gcagtctcaa    120

ccttcctggc tcaagcgatc ctcccacctc agcctcccga gtagctgaga ctacaggcac    180

ttgccaccac acccggctaa ttaaattttt tgttttgttt tcttttaggg ctggggtgtc    240

actatgttgc ccaggctgct ctagaactcc tgggctcaag tgatcctcct gcctctgcct    300

tccaaagtgt tgggattaca ggcatgaacc accatggcta gtttaaatgg tttttcaggg    360

tcacatatct cggaagatat gtgggatgta aacccagcag cctggcccca gagcccatgg    420

tcttcatggc agcagcatgt gtgccgcctc tcatgtgtac aagtgaatga agaatgaaag    480

agagttgcac tctcaccaat gaccagctgc cttctgggtg aagtgaaaca ataccgagaa    540

acaaggaggc ctggtcctac caggccacaa agctgcttga ctgtctgcct aggggaaaag    600

gaattcggcc acatggagaa gaggacaaag atactcagag agaaaaagta aaagaccgaa    660

gaaggaggct ggagagacca ggatccttcc agctgaacaa agtcagccac aaagcagact    720

agccagccgg ctacaattgg agtcagagtc ccaaagacat ggg                      763


<210>  5304
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  5304

Met Thr Ser Cys Leu Leu Gly Glu Val Lys Gln Tyr Arg Glu Thr Arg 
1               5                   10                  15      


Arg Pro Gly Pro Thr Arg Pro Gln Ser Cys Leu Thr Val Cys Leu Gly 
            20                  25                  30          


Glu Lys Glu Phe Gly His Met Glu Lys Arg Thr Lys Ile Leu Arg Glu 
        35                  40                  45              


Lys Lys 
    50  


<210>  5305
<211>  585
<212>  DNA
<213>  Homosapiens

<400>  5305
atggacccat cacagaagtt taatccaacc tacatcccag agtctccaca aatgctcacc     60

gaagaaaatt cccgggacga ttcaggggcc tctcaaatct gctccgagac gttgataaag    120

aaccttagta acttgactat caacactagt agcgaatctg tttcccctct atcggaagct    180

ttactccgtc gagagtctgt aggagcagaa gtcctcaggg aaatcgaaga tgagtggctt    240

tacagcagga gaggaccatt ggggcctaag gacaacctaa cagtaggttg gaagtggggc    300

tcggtgttgt ctgctctaat ccttggccac gtcgtggagt acgagtgctc atggactctg    360

gatcccctga agcccactca caaggagcag atgatttttc tctcctacca ccactgtacc    420

acagatccta aaagttgtct cagatgtcat gctcagtctt tacaaccact cgtctacata    480

taccctccac tatcctgccc ctctcgcact ttgtgttgct tggcaaaagc acgacccctg    540

gctaaatcca gctacatccc catgagcctg cacccataca gctaa                    585


<210>  5306
<211>  194
<212>  PRT
<213>  Homosapiens

<400>  5306

Met Asp Pro Ser Gln Lys Phe Asn Pro Thr Tyr Ile Pro Glu Ser Pro 
1               5                   10                  15      


Gln Met Leu Thr Glu Glu Asn Ser Arg Asp Asp Ser Gly Ala Ser Gln 
            20                  25                  30          


Ile Cys Ser Glu Thr Leu Ile Lys Asn Leu Ser Asn Leu Thr Ile Asn 
        35                  40                  45              


Thr Ser Ser Glu Ser Val Ser Pro Leu Ser Glu Ala Leu Leu Arg Arg 
    50                  55                  60                  


Glu Ser Val Gly Ala Glu Val Leu Arg Glu Ile Glu Asp Glu Trp Leu 
65                  70                  75                  80  


Tyr Ser Arg Arg Gly Pro Leu Gly Pro Lys Asp Asn Leu Thr Val Gly 
                85                  90                  95      


Trp Lys Trp Gly Ser Val Leu Ser Ala Leu Ile Leu Gly His Val Val 
            100                 105                 110         


Glu Tyr Glu Cys Ser Trp Thr Leu Asp Pro Leu Lys Pro Thr His Lys 
        115                 120                 125             


Glu Gln Met Ile Phe Leu Ser Tyr His His Cys Thr Thr Asp Pro Lys 
    130                 135                 140                 


Ser Cys Leu Arg Cys His Ala Gln Ser Leu Gln Pro Leu Val Tyr Ile 
145                 150                 155                 160 


Tyr Pro Pro Leu Ser Cys Pro Ser Arg Thr Leu Cys Cys Leu Ala Lys 
                165                 170                 175     


Ala Arg Pro Leu Ala Lys Ser Ser Tyr Ile Pro Met Ser Leu His Pro 
            180                 185                 190         


Tyr Ser 
        


<210>  5307
<211>  2843
<212>  DNA
<213>  Homosapiens

<400>  5307
atgctagaca agcccccaca gattcaggtt ctagtttcca tcccagggcc aggccagccc     60

cagcaaccct gggctgtaga ccacatctgg gctggcccca gtggtcccag gcctcaggct    120

ggtcccagca acagaacagc ccccacagcc cttgtcatca ggctagcacc tatggaccca    180

gcctccaggt cagcctctgt ggatataggc tccaggccaa cccagctcca acccagcccc    240

ctgcaaccca aggcaccagg cctgccccag ggttcagaac agctgagagc caggtcaact    300

cacacagccc taggctccag gcccatctca gcaccaggtg agtactattg gcctcagcct    360

caggtaccat actggtccca agggaccctg gatccaggac tgtcctcaca gcccaaagct    420

tcgggccagc ctctgtgtca ccagtcacca gaccatcact cttgctacca ggctccagac    480

cagtccccac aaacccaggc ttcacacttg ccacaggacc aggctggccc tgggccccag    540

agggtccaga gtcacagcct gatccagcag acccagggcc caggcctatc ccagtttacc    600

caggctccag accagacact atggactcag gctttaggcc agccaccaag gttacaggct    660

ccaagtctgc ccatgaggac tcaagctcaa gcccacctct acaagccaaa taaacaggtc    720

cattcccatg gattcaggct cctggtccaa accagtggaa tcagacagca ggcccaccta    780

cttactaatg caggatttga catggaagtg aaaggttggg gtggagaaga tgttcatctt    840

tatcgaaaat acttacgtgg tgacctcatt gttattcgga atccagttcc tggtcttttc    900

cacctctggc atgaaaagca ctgtgctgat gagctgaccc ccgagcagta ccgcatgtgc    960

atccagtcta aagccatgga tgaggcttct cgctcccacc tgggaatgct ggtcttcagg   1020

gaggaaatag agacgcatct tcataaacag gcatacagga caaacagcga agctgttggt   1080

tgaaatcata atgccttact gtgtgaacca caaaccaaca ctatttattt agccttgctt   1140

ctactttcag atgcagtgcc tcttttggag aagacatgtt tatttttcat gttctttctg   1200

acattacttt agcaattcaa cttgatgtga gaagaaaaaa caaatgtttc aacacgaaat   1260

ctctgttttg tgagaatact gcactatgga ataattgaca aattgaaatc tcgtatttgt   1320

cccaaaagtt gttttgagtt agttctacct agtgcccatg ttctgattgt gtgtgggatt   1380

gcatggtgtc ctgattgcat ctaggtggag tggatggaat gtgctgggcc actgttgggt   1440

ggagagcagc acattcttac agaggagatg gagtgctatg agcatagtgt gtggacaggt   1500

atcttcacct gcccacccct gagttagcct gcttaatttg atagcttgaa gaatcctttt   1560

ccactgaagt agaggataat taattgacac atctgaaatc cccaatcaat caatcaagag   1620

aaaggtagaa ataaaaactc cttaacttac tgttgcttac acccctgaaa gtctgttttt   1680

aagcaagtgg gtaatagtag aaaataggtt agaatctatg gcttgattaa aaagataatg   1740

ttattacatt atcatgttca ggattaggat tagtagtcag agttgctgta aactattttg   1800

aacaaacaga aaagaacacg gaaacatttt taacagagca cttaattatg ttggactaca   1860

ggatcctagc tgtgtctggg aacattggtt tatgtgagcc agctacatca gggtcttccc   1920

atggtgattc agaatagatg agcatagcat ggtttcgttt gtttttgctt tcaattttct   1980

catttggcat ggatccatat gtatttacta tcctttcttc taatatatta atatatgcta   2040

catttgtatt tgcattacta taatactttg aatggagaaa gtttcattgt ggagagaaaa   2100

agcaaatggt ataccacaag atcaccctga tttgagaaaa gggaggaggg gaagacagtc   2160

tgaatggaaa tctgaaatac ggaatgtttt agagaaatat atcacttgca tatagaatgt   2220

tttaattgag atataaatta atgagacaaa gtgaagaaga aattatattc agataggact   2280

gcactacatt atttctcaca catgtatctg ttaccatcag gtcaattcct agtatgcata   2340

aattttttaa ccattggctt ttaaaagaga cctatgttga aaacccctga aaattcaccg   2400

aagaaaaatc attactcttt ttctcagtaa atcatatcat ctgaaatatt acaaatttca   2460

aatttctagg tgctatatta attcaacatt acaataattc ttacctgatt attcttacaa   2520

gttttaagtt gtggtagttt agtgattttt tttaaagatg tgtgaaatgt tctctgcaaa   2580

ataattcagg ccactgtctc tttgtatata ttattataat tatttattat gaagaccagc   2640

gaattatgat atttaaagtg agagaactta attatttgca aaggtaagtt acagcttgtt   2700

tttttgagag aatcaaatga gtttactttt gttcctgttg tttgtaaact agtttgtagt   2760

ttaaagatgg aagctaagca atggaaatgt tatatgtttt tgacatttat taaatggtac   2820

caataaagta ttttattacc aaa                                           2843


<210>  5308
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  5308

Met Leu Asp Lys Pro Pro Gln Ile Gln Val Leu Val Ser Ile Pro Gly 
1               5                   10                  15      


Pro Gly Gln Pro Gln Gln Pro Trp Ala Val Asp His Ile Trp Ala Gly 
            20                  25                  30          


Pro Ser Gly Pro Arg Pro Gln Ala Gly Pro Ser Asn Arg Thr Ala Pro 
        35                  40                  45              


Thr Ala Leu Val Ile Arg Leu Ala Pro Met Asp Pro Ala Ser Arg Ser 
    50                  55                  60                  


Ala Ser Val Asp Ile Gly Ser Arg Pro Thr Gln Leu Gln Pro Ser Pro 
65                  70                  75                  80  


Leu Gln Pro Lys Ala Pro Gly Leu Pro Gln Gly Ser Glu Gln Leu Arg 
                85                  90                  95      


Ala Arg Ser Thr His Thr Ala Leu Gly Ser Arg Pro Ile Ser Ala Pro 
            100                 105                 110         


Gly Glu Tyr Tyr Trp Pro Gln Pro Gln Val Pro Tyr Trp Ser Gln Gly 
        115                 120                 125             


Thr Leu Asp Pro Gly Leu Ser Ser Gln Pro Lys Ala Ser Gly Gln Pro 
    130                 135                 140                 


Leu Cys His Gln Ser Pro Asp His His Ser Cys Tyr Gln Ala Pro Asp 
145                 150                 155                 160 


Gln Ser Pro Gln Thr Gln Ala Ser His Leu Pro Gln Asp Gln Ala Gly 
                165                 170                 175     


Pro Gly Pro Gln Arg Val Gln Ser His Ser Leu Ile Gln Gln Thr Gln 
            180                 185                 190         


Gly Pro Gly Leu Ser Gln Phe Thr Gln Ala Pro Asp Gln Thr Leu Trp 
        195                 200                 205             


Thr Gln Ala Leu Gly Gln Pro Pro Arg Leu Gln Ala Pro Ser Leu Pro 
    210                 215                 220                 


Met Arg Thr Gln Ala Gln Ala His Leu Tyr Lys Pro Asn Lys Gln Val 
225                 230                 235                 240 


His Ser His Gly Phe Arg Leu Leu Val Gln Thr Ser Gly Ile Arg Gln 
                245                 250                 255     


Gln Ala His Leu Leu Thr Asn Ala Gly Phe Asp Met Glu Val Lys Gly 
            260                 265                 270         


Trp Gly Gly Glu Asp Val His Leu Tyr Arg Lys Tyr Leu Arg Gly Asp 
        275                 280                 285             


Leu Ile Val Ile Arg Asn Pro Val Pro Gly Leu Phe His Leu Trp His 
    290                 295                 300                 


Glu Lys His Cys Ala Asp Glu Leu Thr Pro Glu Gln Tyr Arg Met Cys 
305                 310                 315                 320 


Ile Gln Ser Lys Ala Met Asp Glu Ala Ser Arg Ser His Leu Gly Met 
                325                 330                 335     


Leu Val Phe Arg Glu Glu Ile Glu Thr His Leu His Lys Gln Ala Tyr 
            340                 345                 350         


Arg Thr Asn Ser Glu Ala Val Gly 
        355                 360 


<210>  5309
<211>  2843
<212>  DNA
<213>  Homosapiens

<400>  5309
atgctagaca agcccccaca gattcaggtt ctagtttcca tcccagggcc aggccagccc     60

cagcaaccct gggctgtaga ccacatctgg gctggcccca gtggtcccag gcctcaggct    120

ggtcccagca acagaacagc ccccacagcc cttgtcatca ggctagcacc tatggaccca    180

gcctccaggt cagcctctgt ggatataggc tccaggccaa cccagctcca acccagcccc    240

ctgcaaccca aggcaccagg cctgccccag ggttcagaac agctgagagc caggtcaact    300

cacacagccc taggctccag gcccatctca gcaccaggtg agtactattg gcctcagcct    360

caggtaccat actggtccca agggaccctg gatccaggac tgtcctcaca gcccaaagct    420

tcgggccagc ctctgtgtca ccagtcacca gaccatcact cttgctacca ggctccagac    480

cagtccccac aaacccaggc ttcacacttg ccacaggacc aggctggccc tgggccccag    540

agggtccaga gtcacagcct gatccagcag acccagggcc caggcctatc ccagtttacc    600

caggctccag accagacact atggactcag gctttaggcc agccaccaag gttacaggct    660

ccaagtctgc ccatgaggac tcaagctcaa gcccacctct acaagccaaa taaacaggtc    720

cattcccatg gattcaggct cctggtccaa accagtggaa tcagacagca ggcccaccta    780

cttactaatg caggatttga catggaagtg aaaggttggg gtggagaaga tgttcatctt    840

tatcgaaaat acttacgtgg tgacctcatt gttattcgga atccagttcc tggtcttttc    900

cacctctggc atgaaaagca ctgtgctgat gagctgaccc ccgagcagta ccgcatgtgc    960

atccagtcta aagccatgga tgaggcttct cgctcccacc tgggaatgct ggtcttcagg   1020

gaggaaatag agacgcatct tcataaacag gcatacagga caaacagcga agctgttggt   1080

tgaaatcata atgccttact gtgtgaacca caaaccaaca ctatttattt agccttgctt   1140

ctactttcag atgcagtgcc tcttttggag aagacatgtt tatttttcat gttctttctg   1200

acattacttt agcaattcaa cttgatgtga gaagaaaaaa caaatgtttc aacacgaaat   1260

ctctgttttg tgagaatact gcactatgga ataattgaca aattgaaatc tcgtatttgt   1320

cccaaaagtt gttttgagtt agttctacct agtgcccatg ttctgattgt gtgtgggatt   1380

gcatggtgtc ctgattgcat ctaggtggag tggatggaat gtgctgggcc actgttgggt   1440

ggagagcagc acattcttac agaggagatg gagtgctatg agcatagtgt gtggacaggt   1500

atcttcacct gcccacccct gagttagcct gcttaatttg atagcttgaa gaatcctttt   1560

ccactgaagt agaggataat taattgacac atctgaaatc cccaatcaat caatcaagag   1620

aaaggtagaa ataaaaactc cttaacttac tgttgcttac acccctgaaa gtctgttttt   1680

aagcaagtgg gtaatagtag aaaataggtt agaatctatg gcttgattaa aaagataatg   1740

ttattacatt atcatgttca ggattaggat tagtagtcag agttgctgta aactattttg   1800

aacaaacaga aaagaacacg gaaacatttt taacagagca cttaattatg ttggactaca   1860

ggatcctagc tgtgtctggg aacattggtt tatgtgagcc agctacatca gggtcttccc   1920

atggtgattc agaatagatg agcatagcat ggtttcgttt gtttttgctt tcaattttct   1980

catttggcat ggatccatat gtatttacta tcctttcttc taatatatta atatatgcta   2040

catttgtatt tgcattacta taatactttg aatggagaaa gtttcattgt ggagagaaaa   2100

agcaaatggt ataccacaag atcaccctga tttgagaaaa gggaggaggg gaagacagtc   2160

tgaatggaaa tctgaaatac ggaatgtttt agagaaatat atcacttgca tatagaatgt   2220

tttaattgag atataaatta atgagacaaa gtgaagaaga aattatattc agataggact   2280

gcactacatt atttctcaca catgtatctg ttaccatcag gtcaattcct agtatgcata   2340

aattttttaa ccattggctt ttaaaagaga cctatgttga aaacccctga aaattcaccg   2400

aagaaaaatc attactcttt ttctcagtaa atcatatcat ctgaaatatt acaaatttca   2460

aatttctagg tgctatatta attcaacatt acaataattc ttacctgatt attcttacaa   2520

gttttaagtt gtggtagttt agtgattttt tttaaagatg tgtgaaatgt tctctgcaaa   2580

ataattcagg ccactgtctc tttgtatata ttattataat tatttattat gaagaccagc   2640

gaattatgat atttaaagtg agagaactta attatttgca aaggtaagtt acagcttgtt   2700

tttttgagag aatcaaatga gtttactttt gttcctgttg tttgtaaact agtttgtagt   2760

ttaaagatgg aagctaagca atggaaatgt tatatgtttt tgacatttat taaatggtac   2820

caataaagta ttttattacc aaa                                           2843


<210>  5310
<211>  360
<212>  PRT
<213>  Homosapiens

<400>  5310

Met Leu Asp Lys Pro Pro Gln Ile Gln Val Leu Val Ser Ile Pro Gly 
1               5                   10                  15      


Pro Gly Gln Pro Gln Gln Pro Trp Ala Val Asp His Ile Trp Ala Gly 
            20                  25                  30          


Pro Ser Gly Pro Arg Pro Gln Ala Gly Pro Ser Asn Arg Thr Ala Pro 
        35                  40                  45              


Thr Ala Leu Val Ile Arg Leu Ala Pro Met Asp Pro Ala Ser Arg Ser 
    50                  55                  60                  


Ala Ser Val Asp Ile Gly Ser Arg Pro Thr Gln Leu Gln Pro Ser Pro 
65                  70                  75                  80  


Leu Gln Pro Lys Ala Pro Gly Leu Pro Gln Gly Ser Glu Gln Leu Arg 
                85                  90                  95      


Ala Arg Ser Thr His Thr Ala Leu Gly Ser Arg Pro Ile Ser Ala Pro 
            100                 105                 110         


Gly Glu Tyr Tyr Trp Pro Gln Pro Gln Val Pro Tyr Trp Ser Gln Gly 
        115                 120                 125             


Thr Leu Asp Pro Gly Leu Ser Ser Gln Pro Lys Ala Ser Gly Gln Pro 
    130                 135                 140                 


Leu Cys His Gln Ser Pro Asp His His Ser Cys Tyr Gln Ala Pro Asp 
145                 150                 155                 160 


Gln Ser Pro Gln Thr Gln Ala Ser His Leu Pro Gln Asp Gln Ala Gly 
                165                 170                 175     


Pro Gly Pro Gln Arg Val Gln Ser His Ser Leu Ile Gln Gln Thr Gln 
            180                 185                 190         


Gly Pro Gly Leu Ser Gln Phe Thr Gln Ala Pro Asp Gln Thr Leu Trp 
        195                 200                 205             


Thr Gln Ala Leu Gly Gln Pro Pro Arg Leu Gln Ala Pro Ser Leu Pro 
    210                 215                 220                 


Met Arg Thr Gln Ala Gln Ala His Leu Tyr Lys Pro Asn Lys Gln Val 
225                 230                 235                 240 


His Ser His Gly Phe Arg Leu Leu Val Gln Thr Ser Gly Ile Arg Gln 
                245                 250                 255     


Gln Ala His Leu Leu Thr Asn Ala Gly Phe Asp Met Glu Val Lys Gly 
            260                 265                 270         


Trp Gly Gly Glu Asp Val His Leu Tyr Arg Lys Tyr Leu Arg Gly Asp 
        275                 280                 285             


Leu Ile Val Ile Arg Asn Pro Val Pro Gly Leu Phe His Leu Trp His 
    290                 295                 300                 


Glu Lys His Cys Ala Asp Glu Leu Thr Pro Glu Gln Tyr Arg Met Cys 
305                 310                 315                 320 


Ile Gln Ser Lys Ala Met Asp Glu Ala Ser Arg Ser His Leu Gly Met 
                325                 330                 335     


Leu Val Phe Arg Glu Glu Ile Glu Thr His Leu His Lys Gln Ala Tyr 
            340                 345                 350         


Arg Thr Asn Ser Glu Ala Val Gly 
        355                 360 


<210>  5311
<211>  795
<212>  DNA
<213>  Homosapiens

<400>  5311
atgtctgcca caggggatca agacctgatc caagaggacc aggaggctcc agtgaaccag     60

gagggagcgc aggccgaggc cgtaggtgac cgggagggcg gtgactctgg ccccgacagt    120

ggcaacactg tggccggagt cgcagggccc atgagaggcc tcggggagga ggagggtgag    180

caggcggcag gcttggccgc agcccccggg ggtgggaacg ccgaggaaga ctcagagatc    240

aggatagtag tggagatgtt tctggacatg gtccactccc ttctcctccg catctatcac    300

aacgaccaca tcctgatcag gatgcgtggc ggccgcctga tgcggaggcg ccgcactgcg    360

gcgcccagtg gctcagaaga gccccggctg ttgctggtgc atgagaggct gggcgtgggg    420

gccgcgggtc ctgagggcga gggcctgggc ctgctccagg aggccgcgtt ggtcccagag    480

cctgaggtgc cagcagacct ggccgagatg gccagggagc ctgcagaaga gcccgcagag    540

gaggcctcag agaagcccac agaggaggcc gcagaagagc ccggtggagt actgggtgcc    600

gctgctggtt ataaattggg ctatattttc tgtgaatgtc tggtcccaac atctgtatta    660

ttcttcgcta aagaagtcac taaatatcag catgaaaagt gggatgaaga ggcccaagat    720

gctgcaggca aggaagagaa agaagagaaa gagaaggatg ctgaaaacaa ggtgaagaac    780

tccaaaggga cctag                                                     795


<210>  5312
<211>  264
<212>  PRT
<213>  Homosapiens

<400>  5312

Met Ser Ala Thr Gly Asp Gln Asp Leu Ile Gln Glu Asp Gln Glu Ala 
1               5                   10                  15      


Pro Val Asn Gln Glu Gly Ala Gln Ala Glu Ala Val Gly Asp Arg Glu 
            20                  25                  30          


Gly Gly Asp Ser Gly Pro Asp Ser Gly Asn Thr Val Ala Gly Val Ala 
        35                  40                  45              


Gly Pro Met Arg Gly Leu Gly Glu Glu Glu Gly Glu Gln Ala Ala Gly 
    50                  55                  60                  


Leu Ala Ala Ala Pro Gly Gly Gly Asn Ala Glu Glu Asp Ser Glu Ile 
65                  70                  75                  80  


Arg Ile Val Val Glu Met Phe Leu Asp Met Val His Ser Leu Leu Leu 
                85                  90                  95      


Arg Ile Tyr His Asn Asp His Ile Leu Ile Arg Met Arg Gly Gly Arg 
            100                 105                 110         


Leu Met Arg Arg Arg Arg Thr Ala Ala Pro Ser Gly Ser Glu Glu Pro 
        115                 120                 125             


Arg Leu Leu Leu Val His Glu Arg Leu Gly Val Gly Ala Ala Gly Pro 
    130                 135                 140                 


Glu Gly Glu Gly Leu Gly Leu Leu Gln Glu Ala Ala Leu Val Pro Glu 
145                 150                 155                 160 


Pro Glu Val Pro Ala Asp Leu Ala Glu Met Ala Arg Glu Pro Ala Glu 
                165                 170                 175     


Glu Pro Ala Glu Glu Ala Ser Glu Lys Pro Thr Glu Glu Ala Ala Glu 
            180                 185                 190         


Glu Pro Gly Gly Val Leu Gly Ala Ala Ala Gly Tyr Lys Leu Gly Tyr 
        195                 200                 205             


Ile Phe Cys Glu Cys Leu Val Pro Thr Ser Val Leu Phe Phe Ala Lys 
    210                 215                 220                 


Glu Val Thr Lys Tyr Gln His Glu Lys Trp Asp Glu Glu Ala Gln Asp 
225                 230                 235                 240 


Ala Ala Gly Lys Glu Glu Lys Glu Glu Lys Glu Lys Asp Ala Glu Asn 
                245                 250                 255     


Lys Val Lys Asn Ser Lys Gly Thr 
            260                 


<210>  5313
<211>  2104
<212>  DNA
<213>  Homosapiens

<400>  5313
atggaagaac acagtagtga aagtattatg ccctccttta caaaagggca aagcttttta     60

gaacagagat tcaactacgg ccccgccccg aacactgtgg cacaagctca ggccgcagac    120

ggtgccggcc ccgaggacga cactgaggcc tcccgtgccg ccgccccagc cgaaggccct    180

cctggcggca tccagccgga agccgcagaa ccaaaaccca cggccgaagc cccgaaggcc    240

ccccgagtgg aggagatccc tcagcgcatg accaggaacc gggcgcagat gctcgcgaac    300

cagagcaagc agggcccgcc cccctccgag aaggagtgcg cccccacccc tgccccggtc    360

accagggcca aggcccgcgg ctccgaggac gacgacgccc aggcccagca tccgcgcaaa    420

cgccgctttc agcgctccac ccagcagctg cagcagcagc tgaacacgtc cacgcagcag    480

acgagggagg tgatccagca gacgctggcc gccatcgtgg acgccatcaa gctggatgcc    540

atcgagccct accacagcga cagggccaac ccctacttcg aatacctgca gatcaggaag    600

aagatcgagg agaagcgcaa gatcctgtgc tgtatcacgc cgcaggcgcc ccagtggtac    660

gcccagtacg tcacctacac gggctcctac ctcctggacg gcaagccgct cagcaagctc    720

cacatccccg tgatcgcacc ccctccctcc ctggcggagc ccctgaagga gctgttcagg    780

cagcaggagg ccgtccgggg aaagctgcgt ctacagcaca gcatcgagag ggagaagctg    840

atcgtatcct gtgagcagga gattctgcgg gttcactgcc gggcggccag gaccatcgcc    900

aaccaggcag tgccattcag cacctgcacg atgctgctgg actccgaggt ctacaacatg    960

cccctggaga gccagggtga cgagaacaag tcagtgcgcg accgtttcaa cgcccgccag   1020

ttcatctcct ggctccagga cgtggatgac aagtatgacc gcatgaagac ttgcctcctc   1080

atgcggcagc agcacgaggc cgcggccctg aacgccgtgc agaggatgga gtggcagctg   1140

aaggtgcagg aactggaccc cgccgggcac aagtccctgt gcgtgaacga ggtgccctcc   1200

ttctacgtgc ccatggtcga cgtcaacgac gactttgtat tgttgccggc atgacaccgc   1260

gggacggccg caggacgcag gcgagggccg cacggctgcc caggactgct gctgagcccc   1320

aggggcggag gagggagcgc cctgtccacc cgggcgggga gagaccccga gagagactgc   1380

acttggccac agcgcctcca tcccttccag actggtccag acgtcgggga ggtgaaacac   1440

gtctcttctc taccagctgc cgcggcgggg gcaaagcccc cagagcctca ctggccccgg   1500

cgggatgagg agaccatgcc gggcgcgcac acacggcagc ttctgtttga aaacggcgac   1560

cttcgggccc ttttctccag caactgcaga ggcatttcag gagttggaga acggagtaca   1620

tttttaaaat tttttgttcc attctgatca actaaagaaa attaaggtgt ccacctctca   1680

caaacagtga cctgcaggtc ggaggggcag gagccccatc ccagccgtgg ttctgttgcc   1740

gccgagctgc gacggcctca gactgggctt cagacctggt gcggagcgag gcggagggac   1800

acagagccag gactcccagc cgtattgaaa tggagtcaaa tccgcgtggt ttgtatcttc   1860

tttcctttaa tcttgggcat tttgtttctc tttctgagaa cgtaacttga aacactacag   1920

agccaataat catataaaaa gtgtatccgt aaacgctgta cagttttata taccttcaca   1980

atgtactttt gctgccttct agataattta ttttgcaaca cattactgca cagttgtaaa   2040

taacttatgt actgtaacat cactttcatt tatgtgtaaa gaaataaata aattaattaa   2100

aaaa                                                                2104


<210>  5314
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  5314

Met Glu Glu His Ser Ser Glu Ser Ile Met Pro Ser Phe Thr Lys Gly 
1               5                   10                  15      


Gln Ser Phe Leu Glu Gln Arg Phe Asn Tyr Gly Pro Ala Pro Asn Thr 
            20                  25                  30          


Val Ala Gln Ala Gln Ala Ala Asp Gly Ala Gly Pro Glu Asp Asp Thr 
        35                  40                  45              


Glu Ala Ser Arg Ala Ala Ala Pro Ala Glu Gly Pro Pro Gly Gly Ile 
    50                  55                  60                  


Gln Pro Glu Ala Ala Glu Pro Lys Pro Thr Ala Glu Ala Pro Lys Ala 
65                  70                  75                  80  


Pro Arg Val Glu Glu Ile Pro Gln Arg Met Thr Arg Asn Arg Ala Gln 
                85                  90                  95      


Met Leu Ala Asn Gln Ser Lys Gln Gly Pro Pro Pro Ser Glu Lys Glu 
            100                 105                 110         


Cys Ala Pro Thr Pro Ala Pro Val Thr Arg Ala Lys Ala Arg Gly Ser 
        115                 120                 125             


Glu Asp Asp Asp Ala Gln Ala Gln His Pro Arg Lys Arg Arg Phe Gln 
    130                 135                 140                 


Arg Ser Thr Gln Gln Leu Gln Gln Gln Leu Asn Thr Ser Thr Gln Gln 
145                 150                 155                 160 


Thr Arg Glu Val Ile Gln Gln Thr Leu Ala Ala Ile Val Asp Ala Ile 
                165                 170                 175     


Lys Leu Asp Ala Ile Glu Pro Tyr His Ser Asp Arg Ala Asn Pro Tyr 
            180                 185                 190         


Phe Glu Tyr Leu Gln Ile Arg Lys Lys Ile Glu Glu Lys Arg Lys Ile 
        195                 200                 205             


Leu Cys Cys Ile Thr Pro Gln Ala Pro Gln Trp Tyr Ala Gln Tyr Val 
    210                 215                 220                 


Thr Tyr Thr Gly Ser Tyr Leu Leu Asp Gly Lys Pro Leu Ser Lys Leu 
225                 230                 235                 240 


His Ile Pro Val Ile Ala Pro Pro Pro Ser Leu Ala Glu Pro Leu Lys 
                245                 250                 255     


Glu Leu Phe Arg Gln Gln Glu Ala Val Arg Gly Lys Leu Arg Leu Gln 
            260                 265                 270         


His Ser Ile Glu Arg Glu Lys Leu Ile Val Ser Cys Glu Gln Glu Ile 
        275                 280                 285             


Leu Arg Val His Cys Arg Ala Ala Arg Thr Ile Ala Asn Gln Ala Val 
    290                 295                 300                 


Pro Phe Ser Thr Cys Thr Met Leu Leu Asp Ser Glu Val Tyr Asn Met 
305                 310                 315                 320 


Pro Leu Glu Ser Gln Gly Asp Glu Asn Lys Ser Val Arg Asp Arg Phe 
                325                 330                 335     


Asn Ala Arg Gln Phe Ile Ser Trp Leu Gln Asp Val Asp Asp Lys Tyr 
            340                 345                 350         


Asp Arg Met Lys Thr Cys Leu Leu Met Arg Gln Gln His Glu Ala Ala 
        355                 360                 365             


Ala Leu Asn Ala Val Gln Arg Met Glu Trp Gln Leu Lys Val Gln Glu 
    370                 375                 380                 


Leu Asp Pro Ala Gly His Lys Ser Leu Cys Val Asn Glu Val Pro Ser 
385                 390                 395                 400 


Phe Tyr Val Pro Met Val Asp Val Asn Asp Asp Phe Val Leu Leu Pro 
                405                 410                 415     


Ala 
    


<210>  5315
<211>  2104
<212>  DNA
<213>  Homosapiens

<400>  5315
atggaagaac acagtagtga aagtattatg ccctccttta caaaagggca aagcttttta     60

gaacagagat tcaactacgg ccccgccccg aacactgtgg cacaagctca ggccgcagac    120

ggtgccggcc ccgaggacga cactgaggcc tcccgtgccg ccgccccagc cgaaggccct    180

cctggcggca tccagccgga agccgcagaa ccaaaaccca cggccgaagc cccgaaggcc    240

ccccgagtgg aggagatccc tcagcgcatg accaggaacc gggcgcagat gctcgcgaac    300

cagagcaagc agggcccgcc cccctccgag aaggagtgcg cccccacccc tgccccggtc    360

accagggcca aggcccgcgg ctccgaggac gacgacgccc aggcccagca tccgcgcaaa    420

cgccgctttc agcgctccac ccagcagctg cagcagcagc tgaacacgtc cacgcagcag    480

acgagggagg tgatccagca gacgctggcc gccatcgtgg acgccatcaa gctggatgcc    540

atcgagccct accacagcga cagggccaac ccctacttcg aatacctgca gatcaggaag    600

aagatcgagg agaagcgcaa gatcctgtgc tgtatcacgc cgcaggcgcc ccagtggtac    660

gcccagtacg tcacctacac gggctcctac ctcctggacg gcaagccgct cagcaagctc    720

cacatccccg tgatcgcacc ccctccctcc ctggcggagc ccctgaagga gctgttcagg    780

cagcaggagg ccgtccgggg aaagctgcgt ctacagcaca gcatcgagag ggagaagctg    840

atcgtatcct gtgagcagga gattctgcgg gttcactgcc gggcggccag gaccatcgcc    900

aaccaggcag tgccattcag cacctgcacg atgctgctgg actccgaggt ctacaacatg    960

cccctggaga gccagggtga cgagaacaag tcagtgcgcg accgtttcaa cgcccgccag   1020

ttcatctcct ggctccagga cgtggatgac aagtatgacc gcatgaagac ttgcctcctc   1080

atgcggcagc agcacgaggc cgcggccctg aacgccgtgc agaggatgga gtggcagctg   1140

aaggtgcagg aactggaccc cgccgggcac aagtccctgt gcgtgaacga ggtgccctcc   1200

ttctacgtgc ccatggtcga cgtcaacgac gactttgtat tgttgccggc atgacaccgc   1260

gggacggccg caggacgcag gcgagggccg cacggctgcc caggactgct gctgagcccc   1320

aggggcggag gagggagcgc cctgtccacc cgggcgggga gagaccccga gagagactgc   1380

acttggccac agcgcctcca tcccttccag actggtccag acgtcgggga ggtgaaacac   1440

gtctcttctc taccagctgc cgcggcgggg gcaaagcccc cagagcctca ctggccccgg   1500

cgggatgagg agaccatgcc gggcgcgcac acacggcagc ttctgtttga aaacggcgac   1560

cttcgggccc ttttctccag caactgcaga ggcatttcag gagttggaga acggagtaca   1620

tttttaaaat tttttgttcc attctgatca actaaagaaa attaaggtgt ccacctctca   1680

caaacagtga cctgcaggtc ggaggggcag gagccccatc ccagccgtgg ttctgttgcc   1740

gccgagctgc gacggcctca gactgggctt cagacctggt gcggagccag gcggagggac   1800

acagagccag gactcccagc cgtattgaaa tggagtcaaa tccgcgtggt ttgtatcttc   1860

tttcctttaa tcttgggcat tttgtttctc tttctgagaa cgtaacttga aacactacag   1920

agccaataat catataaaaa gtgtatccgt aaacgctgta cagttttata taccttcaca   1980

atgtactttt gctgccttct agataattta ttttgcaaca cattactgca cagttgtaaa   2040

taacttatgt actgtaacat cactttcatt tatgtgtaaa gaaataaata aattaattaa   2100

aaaa                                                                2104


<210>  5316
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  5316

Met Glu Glu His Ser Ser Glu Ser Ile Met Pro Ser Phe Thr Lys Gly 
1               5                   10                  15      


Gln Ser Phe Leu Glu Gln Arg Phe Asn Tyr Gly Pro Ala Pro Asn Thr 
            20                  25                  30          


Val Ala Gln Ala Gln Ala Ala Asp Gly Ala Gly Pro Glu Asp Asp Thr 
        35                  40                  45              


Glu Ala Ser Arg Ala Ala Ala Pro Ala Glu Gly Pro Pro Gly Gly Ile 
    50                  55                  60                  


Gln Pro Glu Ala Ala Glu Pro Lys Pro Thr Ala Glu Ala Pro Lys Ala 
65                  70                  75                  80  


Pro Arg Val Glu Glu Ile Pro Gln Arg Met Thr Arg Asn Arg Ala Gln 
                85                  90                  95      


Met Leu Ala Asn Gln Ser Lys Gln Gly Pro Pro Pro Ser Glu Lys Glu 
            100                 105                 110         


Cys Ala Pro Thr Pro Ala Pro Val Thr Arg Ala Lys Ala Arg Gly Ser 
        115                 120                 125             


Glu Asp Asp Asp Ala Gln Ala Gln His Pro Arg Lys Arg Arg Phe Gln 
    130                 135                 140                 


Arg Ser Thr Gln Gln Leu Gln Gln Gln Leu Asn Thr Ser Thr Gln Gln 
145                 150                 155                 160 


Thr Arg Glu Val Ile Gln Gln Thr Leu Ala Ala Ile Val Asp Ala Ile 
                165                 170                 175     


Lys Leu Asp Ala Ile Glu Pro Tyr His Ser Asp Arg Ala Asn Pro Tyr 
            180                 185                 190         


Phe Glu Tyr Leu Gln Ile Arg Lys Lys Ile Glu Glu Lys Arg Lys Ile 
        195                 200                 205             


Leu Cys Cys Ile Thr Pro Gln Ala Pro Gln Trp Tyr Ala Gln Tyr Val 
    210                 215                 220                 


Thr Tyr Thr Gly Ser Tyr Leu Leu Asp Gly Lys Pro Leu Ser Lys Leu 
225                 230                 235                 240 


His Ile Pro Val Ile Ala Pro Pro Pro Ser Leu Ala Glu Pro Leu Lys 
                245                 250                 255     


Glu Leu Phe Arg Gln Gln Glu Ala Val Arg Gly Lys Leu Arg Leu Gln 
            260                 265                 270         


His Ser Ile Glu Arg Glu Lys Leu Ile Val Ser Cys Glu Gln Glu Ile 
        275                 280                 285             


Leu Arg Val His Cys Arg Ala Ala Arg Thr Ile Ala Asn Gln Ala Val 
    290                 295                 300                 


Pro Phe Ser Thr Cys Thr Met Leu Leu Asp Ser Glu Val Tyr Asn Met 
305                 310                 315                 320 


Pro Leu Glu Ser Gln Gly Asp Glu Asn Lys Ser Val Arg Asp Arg Phe 
                325                 330                 335     


Asn Ala Arg Gln Phe Ile Ser Trp Leu Gln Asp Val Asp Asp Lys Tyr 
            340                 345                 350         


Asp Arg Met Lys Thr Cys Leu Leu Met Arg Gln Gln His Glu Ala Ala 
        355                 360                 365             


Ala Leu Asn Ala Val Gln Arg Met Glu Trp Gln Leu Lys Val Gln Glu 
    370                 375                 380                 


Leu Asp Pro Ala Gly His Lys Ser Leu Cys Val Asn Glu Val Pro Ser 
385                 390                 395                 400 


Phe Tyr Val Pro Met Val Asp Val Asn Asp Asp Phe Val Leu Leu Pro 
                405                 410                 415     


Ala 
    


<210>  5317
<211>  829
<212>  DNA
<213>  Homosapiens

<400>  5317
aaagggctgg acgctcaccc aagaagggga ccccggcctg acctctctcg gaattcaaaa     60

aaatctaagg ctcagagagg gaatgggagc tggctcttcc ctctgtgttt agcatccacg    120

ttttttggcg gtctggctga aaccagccca ccctagttcg ggcgccagag caacgcagtt    180

ccgagggcag atctccaagg ggcggaggca gagccgcggg tggatcttta actcaagact    240

agcatgaaga gttgccttct ggcctgccct gagtctcctc aaataacaac aggcccttcc    300

accgcagcca tccgcacggg aggcctcgcg attgctcgga accatcccgc aggagttcag    360

ctgatatttt ctagtgtggg gcgagagatt ttgtggagcg catttaaggg gtttttgttg    420

tgactgctgc cttgtataca tttattttct ttcttggaac tgggcctcgc cctcctccca    480

ctgacatgat ggcccagtcc aaggccaatg gctcgcacta tgcgctgacc gccatcggcc    540

tggggatgct ggtccttggg gtgatcatgg ccatgtggaa cctggtaccc ggcttcagcg    600

cggccgagaa gccaacagct cagggcagca acaagaccga ggtgggtggc ggcatcctca    660

agagcaagac cttctctgtg gcctacgtgc tggtcggggc cggggtgatg ctgctgctgc    720

tttctatctg cctgagtatc agggataaga ggaagcagcg gcagggcgag gacctggccc    780

atgtccagca cccgacaggc gctgggcctc acgcccagga ggaagacag                829


<210>  5318
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  5318

Met Lys Ser Cys Leu Leu Ala Cys Pro Glu Ser Pro Gln Ile Thr Thr 
1               5                   10                  15      


Gly Pro Ser Thr Ala Ala Ile Arg Thr Gly Gly Leu Ala Ile Ala Arg 
            20                  25                  30          


Asn His Pro Ala Gly Val Gln Leu Ile Phe Ser Ser Val Gly Arg Glu 
        35                  40                  45              


Ile Leu Trp Ser Ala Phe Lys Gly Phe Leu Leu 
    50                  55                  


<210>  5319
<211>  1979
<212>  DNA
<213>  Homosapiens

<400>  5319
gctggacgct cacccaagaa ggggaccccg gcctgacctc tctcggaatt caaaaaaatc     60

taaggctcag agagggaatg ggagctggct cttccctctg tgtttagcat ccacgttttt    120

tggcggtctg gctgaaacca gcccacccta gttcgggcgc cagagcaacg cagttccgag    180

ggcagatctc caaggggcgg aggcagagcc gcgggtggat ctttaactca agactagcat    240

gaagagttgc cttctggcct gccctgagtc tcctcaaata acaacaggcc cttccaccgc    300

agccatccgc acgggaggcc tcgcgattgc tcggaaccat cccgcaggag ttcagctgat    360

attttctagt gtggggcgag agattttgtg gagcgcattt aaggggtttt tgttgtgact    420

gctgccttgt atacatttat tttctttctt ggaactgggc ctcgccctcc tcccactgac    480

atgatggccc agtccaaggc caatggctcg cactatgcgc tgaccgccat cggcctgggg    540

atgctggtcc ttggggtgat catggccatg tggaacctgg tacccggctt cagcgcggcc    600

gagaagccaa cagctcaggg cagcaacaag accgaggtgg gtggcggcat cctcaagagc    660

aagaccttct ctgtggccta cgtgctggtc ggggccgggg tgatgctgct gctgctttct    720

atctgcctga gtatcaggga taagaggaag cagcggcagg gcgaggacct ggcccatgtc    780

cagcacccga caggcgctgg gcctcacgcc caggaggaag acagccagga ggaagaagag    840

gaggatgagg aggctgcctc aaggtactat gttcccagct acgaggaagt gatgaacaca    900

aactactcag aagcaagggg agaggagcag aacccgaggt tgagcatctc tctcccgtcc    960

tatgagtcac tgacggggct cgacgagacc acccccacat ccaccagggc tgacgtggag   1020

gccagccctg ggaacccccc tgacaggcag aactctaagt tggccaaacg actgaaaccg   1080

ctgaaagttc gaaggattaa atctgaaaag cttcacctca aagactttag gatcaacctc   1140

ccagacaaaa acgtccctcc tccctcgata gagcctttga ctcctccacc gcagtatgat   1200

gaagtccagg agaaggcccc cgacacccgg ccgcccgact gaatggcccc acttgagcca   1260

cgctccctcc tgtctctcac acctttcacc cccaagactc taacaaagcc acatgagcca   1320

cagttgagaa gcggaggggc cagctgtgca tggagccatt tggatggcgg cgggcggggg   1380

gggattctct gtatcaggag tgactttgtt gccccacaca gcctcctgct gcaggtgctt   1440

tggaaagaga tgctgccttg gagctggtga atctgtggac cacattcaag ggtgtggcac   1500

aggcatcttc ccatcctttt cactccgaat cgctggcgac acattctcct ttccagctag   1560

gaaagggttc ctcgcggctg gtttagattg tggttgtttg ttttgcttct actaagactg   1620

ttttgtttca aaaaggaaac aagttttgtg tttgctgtct acgctggagt cctgaactgt   1680

gggtagaaaa cacgacctgg ctttgtagaa aggacacagg gctgttttat gaactaagcg   1740

gtgaggctca ggtggcggct ctcgcagagc ccctgatgct gttgttcttt gagggcttaa   1800

ggcctgatga acgtaggcac gtgatgcata atagtcttca atggtacact taactagtct   1860

cttctgtgta acagcaaaaa aaaaaaaaaa aagaagaaga aagaaaactg taggaaatgt   1920

tctttttgaa atgccatgca atggagcttt ttgtaataaa atattttata tgtagtaca    1979


<210>  5320
<211>  253
<212>  PRT
<213>  Homosapiens

<400>  5320

Met Met Ala Gln Ser Lys Ala Asn Gly Ser His Tyr Ala Leu Thr Ala 
1               5                   10                  15      


Ile Gly Leu Gly Met Leu Val Leu Gly Val Ile Met Ala Met Trp Asn 
            20                  25                  30          


Leu Val Pro Gly Phe Ser Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser 
        35                  40                  45              


Asn Lys Thr Glu Val Gly Gly Gly Ile Leu Lys Ser Lys Thr Phe Ser 
    50                  55                  60                  


Val Ala Tyr Val Leu Val Gly Ala Gly Val Met Leu Leu Leu Leu Ser 
65                  70                  75                  80  


Ile Cys Leu Ser Ile Arg Asp Lys Arg Lys Gln Arg Gln Gly Glu Asp 
                85                  90                  95      


Leu Ala His Val Gln His Pro Thr Gly Ala Gly Pro His Ala Gln Glu 
            100                 105                 110         


Glu Asp Ser Gln Glu Glu Glu Glu Glu Asp Glu Glu Ala Ala Ser Arg 
        115                 120                 125             


Tyr Tyr Val Pro Ser Tyr Glu Glu Val Met Asn Thr Asn Tyr Ser Glu 
    130                 135                 140                 


Ala Arg Gly Glu Glu Gln Asn Pro Arg Leu Ser Ile Ser Leu Pro Ser 
145                 150                 155                 160 


Tyr Glu Ser Leu Thr Gly Leu Asp Glu Thr Thr Pro Thr Ser Thr Arg 
                165                 170                 175     


Ala Asp Val Glu Ala Ser Pro Gly Asn Pro Pro Asp Arg Gln Asn Ser 
            180                 185                 190         


Lys Leu Ala Lys Arg Leu Lys Pro Leu Lys Val Arg Arg Ile Lys Ser 
        195                 200                 205             


Glu Lys Leu His Leu Lys Asp Phe Arg Ile Asn Leu Pro Asp Lys Asn 
    210                 215                 220                 


Val Pro Pro Pro Ser Ile Glu Pro Leu Thr Pro Pro Pro Gln Tyr Asp 
225                 230                 235                 240 


Glu Val Gln Glu Lys Ala Pro Asp Thr Arg Pro Pro Asp 
                245                 250             


<210>  5321
<211>  2081
<212>  DNA
<213>  Homosapiens

<400>  5321
gacttcgggt ttgcactccc cggagccaga actccgtggc ggctccgggc ctccgtggat     60

ccgagcagag actggctgcc cgcctgccac tcgcaggctg ggaaaacgcc agccggtgcc    120

tcgccgggaa agttctcggc aaagctgggg atgagccctc agcagggcag gctcccggtg    180

cagcgcgccc ccatccattg cccgcgcgca agaacccgga atgggcccca cctgggccgg    240

gactcgggcg tgcgatcccg agggcgccct ggggaccacg catcgggtgg ggaccctggc    300

cgagggcgtg agctgactca gtttttaaaa actcgcttcc tccttcccta cttgtgccgg    360

tcactcacct cgctgggaac cagcccaggg cagaaggggg agagggaggc ggtggcctcc    420

ccaggaagga ggagaggtgg atctttaact caagactagc atgaagagtt gccttctggc    480

ctgccctgag tctcctcaaa taacaacagg cccttccacc gcagccatcc gcacgggagg    540

cctcgcgatt gctcggaacc atcccgcagg agttcagctg atattttcta gtgtggggcg    600

agagattttg tggagcgcat ttaaggggtt tttgttgtga ctgctgcctt gtatacattt    660

attttctttc ttggaactgg gcctcgccct cctcccactg acatgatggc ccagtccaag    720

gccaatggct cgcactatgc gctgaccgcc atcggcctgg ggatgctggt ccttggggtg    780

atcatggcca tgtggaacct ggtacccggc ttcagcgcgg ccgagaagcc aacagctcag    840

ggcagcaaca agaccgaggt gggtggcggc atcctcaaga gcaagacctt ctctgtggcc    900

tacgtgctgg tcggggccgg ggtgatgctg ctgctgcttt ctatctgcct gagtatcagg    960

gataagagga agcagcggca gggcgaggac ctggcccatg tccagcaccc gacaggcgct   1020

gggcctcacg cccaggagga agacagccag gaggaagaag aggaggatga ggaggctgcc   1080

tcaaggtact atgttcccag ctacgaggaa gtgatgaaca caaactactc agaagcaagg   1140

ggagaggagc agaactctaa gttggccaaa cgactgaaac cgctgaaagt tcgaaggatt   1200

aaatctgaaa agcttcacct caaagacttt aggatcaacc tcccagacaa aaacgtccct   1260

cctccctcga tagagccttt gactcctcca ccgcagtatg atgaagtcca ggagaaggcc   1320

cccgacaccc ggccgcccga ctgaatggcc ccacttgagc cacgctccct cctgtctctc   1380

acacctttca cccccaagac tctaacaaag ccacatgagc cacagttgag aagcggaggg   1440

gccagctgtg catggagcca tttggatggc ggcgggcggg gggggattct ctgtatcagg   1500

agtgactttg ttgccccaca cagcctcctg ctgcaggtgc tttggaaaga gatgctgcct   1560

tggagctggt gaatctgtgg accacattca agggtgtggc acaggcatct tcccatcctt   1620

ttcactccga atcgctggcg acacattctc ctttccagct aggaaagggt tcctcgcggc   1680

tggtttagat tgtggttgtt tgttttgctt ctactaagac tgttttgttt caaaaaggaa   1740

acaagttttg tgtttgctgt ctacgctgga gtcctgaact gtgggtagaa aacacgacct   1800

ggctttgtag aaaggacaca gggctgtttt atgaactaag cggtgaggct caggtggcgg   1860

ctctcgcaga gcccctgatg ctgttgttct ttgagggctt aaggcctgat gaacgtaggc   1920

acgtgatgca taatagtctt caatggtaca cttaactagt ctcttctgtg taacagcaaa   1980

aaaaaaaaaa aaaagaagaa gaaagaaaac tgtaggaaat gttctttttg aaatgccatg   2040

caatggagct ttttgtaata aaatatttta tatgtagtac a                       2081


<210>  5322
<211>  213
<212>  PRT
<213>  Homosapiens

<400>  5322

Met Met Ala Gln Ser Lys Ala Asn Gly Ser His Tyr Ala Leu Thr Ala 
1               5                   10                  15      


Ile Gly Leu Gly Met Leu Val Leu Gly Val Ile Met Ala Met Trp Asn 
            20                  25                  30          


Leu Val Pro Gly Phe Ser Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser 
        35                  40                  45              


Asn Lys Thr Glu Val Gly Gly Gly Ile Leu Lys Ser Lys Thr Phe Ser 
    50                  55                  60                  


Val Ala Tyr Val Leu Val Gly Ala Gly Val Met Leu Leu Leu Leu Ser 
65                  70                  75                  80  


Ile Cys Leu Ser Ile Arg Asp Lys Arg Lys Gln Arg Gln Gly Glu Asp 
                85                  90                  95      


Leu Ala His Val Gln His Pro Thr Gly Ala Gly Pro His Ala Gln Glu 
            100                 105                 110         


Glu Asp Ser Gln Glu Glu Glu Glu Glu Asp Glu Glu Ala Ala Ser Arg 
        115                 120                 125             


Tyr Tyr Val Pro Ser Tyr Glu Glu Val Met Asn Thr Asn Tyr Ser Glu 
    130                 135                 140                 


Ala Arg Gly Glu Glu Gln Asn Ser Lys Leu Ala Lys Arg Leu Lys Pro 
145                 150                 155                 160 


Leu Lys Val Arg Arg Ile Lys Ser Glu Lys Leu His Leu Lys Asp Phe 
                165                 170                 175     


Arg Ile Asn Leu Pro Asp Lys Asn Val Pro Pro Pro Ser Ile Glu Pro 
            180                 185                 190         


Leu Thr Pro Pro Pro Gln Tyr Asp Glu Val Gln Glu Lys Ala Pro Asp 
        195                 200                 205             


Thr Arg Pro Pro Asp 
    210             


<210>  5323
<211>  1810
<212>  DNA
<213>  Homosapiens

<400>  5323
acgccggcgc tcccaggccg cgcttcctgc gtccccaacc cggtccctga gagggcagtg     60

cgccctctcc accactgcgt tccctcggct aagaatcccc cgaaccccag ccccgcgatc    120

gcggcgccca ccgaggaggc cgcccgggtg gggcgcgggg gtcgcgaagc ccgcagtccc    180

ggaccgccca gccgagacgg agccggaccc gccgcctccc gggcccttcc accgcagcca    240

tccgcacggg aggcctcgcg attgctcgga accatcccgc aggagttcag ctgatatttt    300

ctagtgtggg gcgagagatt ttgtggagcg catttaaggg gtttttgttg tgactgctgc    360

cttgtataca tttattttct ttcttggaac tgggcctcgc cctcctccca ctgacatgat    420

ggcccagtcc aaggccaatg gctcgcacta tgcgctgacc gccatcggcc tggggatgct    480

ggtccttggg gtgatcatgg ccatgtggaa cctggtaccc ggcttcagcg cggccgagaa    540

gccaacagct cagggcagca acaagaccga ggtgggtggc ggcatcctca agagcaagac    600

cttctctgtg gcctacgtgc tggtcggggc cggggtgatg ctgctgctgc tttctatctg    660

cctgagtatc agggataaga ggaagcagcg gcagggcgag gacctggccc atgtccagca    720

cccgacaggc gctgggcctc acgcccagga ggaagacagc caggaggaag aagaggagga    780

tgaggaggct gcctcaaggt actatgttcc cagctacgag gaagtgatga acacaaacta    840

ctcagaagca aggggagagg agcagaaccc gaggttgagc atctctctcc cgtcctatga    900

gtcactgacg gggctcgacg agaccacccc cacatccacc agggctgacg tggaggccag    960

ccctgggaac ccccctgaca ggcagaactc taagttggcc aaacgactga aaccgctgaa   1020

agttcgaagg attaaatctg aaaagcttca cctcaaagac tttaggatca acctcccaga   1080

caaaaacgtc cctcctccct cgatagagcc tttgactcct ccaccgcagt atgatgaagt   1140

ccaggagaag gcccccgaca cccggccgcc cgactgaatg gccccacttg agccacgctc   1200

cctcctgtct ctcacacctt tcacccccaa gactctaaca aagccacatg agccacagtt   1260

gagaagcgga ggggccagct gtgcatggag ccatttggat ggcggcgggc ggggggggat   1320

tctctgtatc aggagtgact ttgttgcccc acacagcctc ctgctgcagg tgctttggaa   1380

agagatgctg ccttggagct ggtgaatctg tggaccacat tcaagggtgt ggcacaggca   1440

tcttcccatc cttttcactc cgaatcgctg gcgacacatt ctcctttcca gctaggaaag   1500

ggttcctcgc ggctggttta gattgtggtt gtttgttttg cttctactaa gactgttttg   1560

tttcaaaaag gaaacaagtt ttgtgtttgc tgtctacgct ggagtcctga actgtgggta   1620

gaaaacacga cctggctttg tagaaaggac acagggctgt tttatgaact aagcggtgag   1680

gctcaggtgg cggctctcgc agagcccctg atgctgttgt tctttgaggg cttaaggcct   1740

gatgaacgta ggcacgtgat gcataatagt cttcaatggt acacttaact agtctcttct   1800

gtgtaacagc                                                          1810


<210>  5324
<211>  253
<212>  PRT
<213>  Homosapiens

<400>  5324

Met Met Ala Gln Ser Lys Ala Asn Gly Ser His Tyr Ala Leu Thr Ala 
1               5                   10                  15      


Ile Gly Leu Gly Met Leu Val Leu Gly Val Ile Met Ala Met Trp Asn 
            20                  25                  30          


Leu Val Pro Gly Phe Ser Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser 
        35                  40                  45              


Asn Lys Thr Glu Val Gly Gly Gly Ile Leu Lys Ser Lys Thr Phe Ser 
    50                  55                  60                  


Val Ala Tyr Val Leu Val Gly Ala Gly Val Met Leu Leu Leu Leu Ser 
65                  70                  75                  80  


Ile Cys Leu Ser Ile Arg Asp Lys Arg Lys Gln Arg Gln Gly Glu Asp 
                85                  90                  95      


Leu Ala His Val Gln His Pro Thr Gly Ala Gly Pro His Ala Gln Glu 
            100                 105                 110         


Glu Asp Ser Gln Glu Glu Glu Glu Glu Asp Glu Glu Ala Ala Ser Arg 
        115                 120                 125             


Tyr Tyr Val Pro Ser Tyr Glu Glu Val Met Asn Thr Asn Tyr Ser Glu 
    130                 135                 140                 


Ala Arg Gly Glu Glu Gln Asn Pro Arg Leu Ser Ile Ser Leu Pro Ser 
145                 150                 155                 160 


Tyr Glu Ser Leu Thr Gly Leu Asp Glu Thr Thr Pro Thr Ser Thr Arg 
                165                 170                 175     


Ala Asp Val Glu Ala Ser Pro Gly Asn Pro Pro Asp Arg Gln Asn Ser 
            180                 185                 190         


Lys Leu Ala Lys Arg Leu Lys Pro Leu Lys Val Arg Arg Ile Lys Ser 
        195                 200                 205             


Glu Lys Leu His Leu Lys Asp Phe Arg Ile Asn Leu Pro Asp Lys Asn 
    210                 215                 220                 


Val Pro Pro Pro Ser Ile Glu Pro Leu Thr Pro Pro Pro Gln Tyr Asp 
225                 230                 235                 240 


Glu Val Gln Glu Lys Ala Pro Asp Thr Arg Pro Pro Asp 
                245                 250             


<210>  5325
<211>  1914
<212>  DNA
<213>  Homosapiens

<400>  5325
acgccggcgc tcccaggccg cgcttcctgc gtccccaacc cggtccctga gagggcagtg     60

cgccctctcc accactgcgt tccctcggct aagaatcccc cgaaccccag ccccgcgatc    120

gcggcgccca ccgaggaggc cgcccgggtg gggcgcgggg gtcgcgaagc ccgcagtccc    180

ggaccgccca gccgagacgg agccggaccc gccgcctccc gggcccttcc accgcagcca    240

tccgcacggg aggcctcgcg attgctcgga accatcccgc aggagttcag ctgatatttt    300

ctagtgtggg gcgagagatt ttgtggagcg catttaaggg gtttttgttg tgactgctgc    360

cttgtataca tttattttct ttcttggaac tgggcctcgc cctcctccca ctgacatgat    420

ggcccagtcc aaggccaatg gctcgcacta tgcgctgacc gccatcggcc tggggatgct    480

ggtccttggg gtgatcatgg ccatgtggaa cctggtaccc ggcttcagcg cggccgagaa    540

gccaacagct cagggcagca acaagaccga ggtgggtggc ggcatcctca agagcaagac    600

cttctctgtg gcctacgtgc tggtcggggc cggggtgatg ctgctgctgc tttctatctg    660

cctgagtatc agggataaga ggaagcagcg gcagggcgag gacctggccc atgtccagca    720

cccgacaggc gctgggcctc acgcccagga ggaagacagc caggaggaag aagaggagga    780

tgaggaggct gcctcaaggt actatgttcc cagctacgag gaagtgatga acacaaacta    840

ctcagaagca aggggagagg agcagaaccc gaggttgagc atctctctcc cgtcctatga    900

gtcactgacg gggctcgacg agaccacccc cacatccacc agggctgacg tggaggccag    960

ccctgggaac ccccctgaca ggcagaactc taagttggcc aaacgactga aaccgctgaa   1020

agttcgaagg attaaatctg aaaagcttca cctcaaagac tttaggatca acctcccaga   1080

caaaaacgtc cctcctccct cgatagagcc tttgactcct ccaccgcagt atgatgaagt   1140

ccaggagaag gcccccgaca cccggccgcc cgactgaatg gccccacttg agccacgctc   1200

cctcctgtct ctcacacctt tcacccccaa gactctaaca aagccacatg agccacagtt   1260

gagaagcgga ggggccagct gtgcatggag ccatttggat ggcggcgggc ggggggggat   1320

tctctgtatc aggagtgact ttgttgcccc acacagcctc ctgctgcagg tgctttggaa   1380

agagatgctg ccttggagct ggtgaatctg tggaccacat tcaagggtgt ggcacaggca   1440

tcttcccatc cttttcactc cgaatcgctg gcgacacatt ctcctttcca gctaggaaag   1500

ggttcctcgc ggctggttta gattgtggtt gtttgttttg cttctactaa gactgttttg   1560

tttcaaaaag gaaacaagtt ttgtgtttgc tgtctacgct ggagtcctga actgtgggta   1620

gaaaacacga cctggctttg tagaaaggac acagggctgt tttatgaact aagcggtgag   1680

gctcaggtgg cggctctcgc agagcccctg atgctgttgt tctttgaggg cttaaggcct   1740

gatgaacgta ggcacgtgat gcataatagt cttcaatggt acacttaact agtctcttct   1800

gtgtaacagc aaaaaaaaaa aaaaaaagaa gaagaaagaa aactgtagga aatgttcttt   1860

ttgaaatgcc atgcaatgga gctttttgta ataaaatatt ttatatgtag taca         1914


<210>  5326
<211>  253
<212>  PRT
<213>  Homosapiens

<400>  5326

Met Met Ala Gln Ser Lys Ala Asn Gly Ser His Tyr Ala Leu Thr Ala 
1               5                   10                  15      


Ile Gly Leu Gly Met Leu Val Leu Gly Val Ile Met Ala Met Trp Asn 
            20                  25                  30          


Leu Val Pro Gly Phe Ser Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser 
        35                  40                  45              


Asn Lys Thr Glu Val Gly Gly Gly Ile Leu Lys Ser Lys Thr Phe Ser 
    50                  55                  60                  


Val Ala Tyr Val Leu Val Gly Ala Gly Val Met Leu Leu Leu Leu Ser 
65                  70                  75                  80  


Ile Cys Leu Ser Ile Arg Asp Lys Arg Lys Gln Arg Gln Gly Glu Asp 
                85                  90                  95      


Leu Ala His Val Gln His Pro Thr Gly Ala Gly Pro His Ala Gln Glu 
            100                 105                 110         


Glu Asp Ser Gln Glu Glu Glu Glu Glu Asp Glu Glu Ala Ala Ser Arg 
        115                 120                 125             


Tyr Tyr Val Pro Ser Tyr Glu Glu Val Met Asn Thr Asn Tyr Ser Glu 
    130                 135                 140                 


Ala Arg Gly Glu Glu Gln Asn Pro Arg Leu Ser Ile Ser Leu Pro Ser 
145                 150                 155                 160 


Tyr Glu Ser Leu Thr Gly Leu Asp Glu Thr Thr Pro Thr Ser Thr Arg 
                165                 170                 175     


Ala Asp Val Glu Ala Ser Pro Gly Asn Pro Pro Asp Arg Gln Asn Ser 
            180                 185                 190         


Lys Leu Ala Lys Arg Leu Lys Pro Leu Lys Val Arg Arg Ile Lys Ser 
        195                 200                 205             


Glu Lys Leu His Leu Lys Asp Phe Arg Ile Asn Leu Pro Asp Lys Asn 
    210                 215                 220                 


Val Pro Pro Pro Ser Ile Glu Pro Leu Thr Pro Pro Pro Gln Tyr Asp 
225                 230                 235                 240 


Glu Val Gln Glu Lys Ala Pro Asp Thr Arg Pro Pro Asp 
                245                 250             


<210>  5327
<211>  818
<212>  DNA
<213>  Homosapiens

<400>  5327
aggccgcgct tcctgcgtcc ccaacccggt ccctgagagg gcagtgcgcc ctctccacca     60

ctgcgttccc tcggctaaga atcccccgaa ccccagcccc gcgatcgcgg cgcccaccga    120

ggaggccgcc cgggtggggc gcgggggtcg cgaagcccgc agtcccggac cgcccagccg    180

agacggagcc ggacccgccg cctcccgggt ggatctttaa ctcaagacta gcatgaagag    240

ttgccttctg gcctgccctg agtctcctca aataacaaca ggcccttcca ccgcagccat    300

ccgcacggga ggcctcgcga ttgctcggaa ccatcccgca ggagttcagc tgatattttc    360

tagtgtgggg cgagagattt tgtggagcgc atttaagggg tttttgttgt gactgctgcc    420

ttgtatacat ttattttctt tcttggaact gggcctcgcc ctcctcccac tgacatgatg    480

gcccagtcca aggccaatgg ctcgcactat gcgctgaccg ccatcggcct ggggatgctg    540

gtccttgggg tgatcatggc catgtggaac ctggtacccg gcttcagcgc ggccgagaag    600

ccaacagctc agggcagcaa caagaccgag gtgggtggcg gcatcctcaa gagcaagacc    660

ttctctgtgg cctacgtgct ggtcggggcc ggggtgatgc tgctgctgct ttctatctgc    720

ctgagtatca gggataagag gaagcagcgg cagggcgagg acctggccca tgtccagcac    780

ccgacaggcg ctgggcctca cgcccaggag gaagacag                            818


<210>  5328
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  5328

Met Lys Ser Cys Leu Leu Ala Cys Pro Glu Ser Pro Gln Ile Thr Thr 
1               5                   10                  15      


Gly Pro Ser Thr Ala Ala Ile Arg Thr Gly Gly Leu Ala Ile Ala Arg 
            20                  25                  30          


Asn His Pro Ala Gly Val Gln Leu Ile Phe Ser Ser Val Gly Arg Glu 
        35                  40                  45              


Ile Leu Trp Ser Ala Phe Lys Gly Phe Leu Leu 
    50                  55                  


<210>  5329
<211>  1952
<212>  DNA
<213>  Homosapiens

<400>  5329
caacccggtc cctgagaggg cagtgcgccc tctccaccac tgcgttccct cggctaagaa     60

tcccccgaac cccagccccg cgatcgcggc gcccaccgag gaggccgccc gggtggggcg    120

cgggggtcgc gaagcccgca gtcccggacc gcccagccga gacggagccg gacccgccgc    180

ctcccgggtg gatctttaac tcaagactag catgaagagt tgccttctgg cctgccctga    240

gtctcctcaa ataacaacag gcccttccac cgcagccatc cgcacgggag gcctcgcgat    300

tgctcggaac catcccgcag gagttcagct gatattttct agtgtggggc gagagatttt    360

gtggagcgca tttaaggggt ttttgttgtg actgctgcct tgtatacatt tattttcttt    420

cttggaactg ggcctcgccc tcctcccact gacatgatgg cccagtccaa ggccaatggc    480

tcgcactatg cgctgaccgc catcggcctg gggatgctgg tccttggggt gatcatggcc    540

atgtggaacc tggtacccgg cttcagcgcg gccgagaagc caacagctca gggcagcaac    600

aagaccgagg tgggtggcgg catcctcaag agcaagacct tctctgtggc ctacgtgctg    660

gtcggggccg gggtgatgct gctgctgctt tctatctgcc tgagtatcag ggataagagg    720

aagcagcggc agggcgagga cctggcccat gtccagcacc cgacaggcgc tgggcctcac    780

gcccaggagg aagacagcca ggaggaagaa gaggaggatg aggaggctgc ctcaaggtac    840

tatgttccca gctacgagga agtgatgaac acaaactact cagaagcaag gggagaggag    900

cagaacccga ggttgagcat ctctctcccg tcctatgagt cactgacggg gctcgacgag    960

accaccccca catccaccag ggctgacgtg gaggccagcc ctgggaaccc ccctgacagg   1020

cagaactcta agttggccaa acgactgaaa ccgctgaaag ttcgaaggat taaatctgaa   1080

aagcttcacc tcaaagactt taggatcaac ctcccagaca aaaacgtccc tcctccctcg   1140

atagagcctt tgactcctcc accgcagtat gatgaagtcc aggagaaggc ccccgacacc   1200

cggccgcccg actgaatggc cccacttgag ccacgctccc tcctgtctct cacacctttc   1260

acccccaaga ctctaacaaa gccacatgag ccacagttga gaagcggagg ggccagctgt   1320

gcatggagcc atttggatgg cggcgggcgg ggggggattc tctgtatcag gagtgacttt   1380

gttgccccac acagcctcct gctgcaggtg ctttggaaag agatgctgcc ttggagctgg   1440

tgaatctgtg gaccacattc aagggtgtgg cacaggcatc ttcccatcct tttcactccg   1500

aatcgctggc gacacattct cctttccagc taggaaaggg ttcctcgcgg ctggtttaga   1560

ttgtggttgt ttgttttgct tctactaaga ctgttttgtt tcaaaaagga aacaagtttt   1620

gtgtttgctg tctacgctgg agtcctgaac tgtgggtaga aaacacgacc tggctttgta   1680

gaaaggacac agggctgttt tatgaactaa gcggtgaggc tcaggtggcg gctctcgcag   1740

agcccctgat gctgttgttc tttgagggct taaggcctga tgaacgtagg cacgtgatgc   1800

ataatagtct tcaatggtac acttaactag tctcttctgt gtaacagcaa aaaaaaaaaa   1860

aaaaagaaga agaaagaaaa ctgtaggaaa tgttcttttt gaaatgccat gcaatggagc   1920

tttttgtaat aaaatatttt atatgtagta ca                                 1952


<210>  5330
<211>  253
<212>  PRT
<213>  Homosapiens

<400>  5330

Met Met Ala Gln Ser Lys Ala Asn Gly Ser His Tyr Ala Leu Thr Ala 
1               5                   10                  15      


Ile Gly Leu Gly Met Leu Val Leu Gly Val Ile Met Ala Met Trp Asn 
            20                  25                  30          


Leu Val Pro Gly Phe Ser Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser 
        35                  40                  45              


Asn Lys Thr Glu Val Gly Gly Gly Ile Leu Lys Ser Lys Thr Phe Ser 
    50                  55                  60                  


Val Ala Tyr Val Leu Val Gly Ala Gly Val Met Leu Leu Leu Leu Ser 
65                  70                  75                  80  


Ile Cys Leu Ser Ile Arg Asp Lys Arg Lys Gln Arg Gln Gly Glu Asp 
                85                  90                  95      


Leu Ala His Val Gln His Pro Thr Gly Ala Gly Pro His Ala Gln Glu 
            100                 105                 110         


Glu Asp Ser Gln Glu Glu Glu Glu Glu Asp Glu Glu Ala Ala Ser Arg 
        115                 120                 125             


Tyr Tyr Val Pro Ser Tyr Glu Glu Val Met Asn Thr Asn Tyr Ser Glu 
    130                 135                 140                 


Ala Arg Gly Glu Glu Gln Asn Pro Arg Leu Ser Ile Ser Leu Pro Ser 
145                 150                 155                 160 


Tyr Glu Ser Leu Thr Gly Leu Asp Glu Thr Thr Pro Thr Ser Thr Arg 
                165                 170                 175     


Ala Asp Val Glu Ala Ser Pro Gly Asn Pro Pro Asp Arg Gln Asn Ser 
            180                 185                 190         


Lys Leu Ala Lys Arg Leu Lys Pro Leu Lys Val Arg Arg Ile Lys Ser 
        195                 200                 205             


Glu Lys Leu His Leu Lys Asp Phe Arg Ile Asn Leu Pro Asp Lys Asn 
    210                 215                 220                 


Val Pro Pro Pro Ser Ile Glu Pro Leu Thr Pro Pro Pro Gln Tyr Asp 
225                 230                 235                 240 


Glu Val Gln Glu Lys Ala Pro Asp Thr Arg Pro Pro Asp 
                245                 250             


<210>  5331
<211>  1686
<212>  DNA
<213>  Homosapiens

<400>  5331
cggtccctga gagggcagtg cgccctctcc accactgcgt tccctcggct aagaatcccc     60

cgaaccccag ccccgcgatc gcggcgccca ccgaggaggc cgcccgggtg gggcgcgggg    120

gtcgcgaagc ccgcagtccc ggaccgccca gccgagacgg agccggaccc gccgcctccc    180

gggcccttcc accgcagcca tccgcacggg aggcctcgcg attgctcgga accatcccgc    240

aggagttcag ctgatatttt ctagtgtggg gcgagagatt ttgtggagcg catttaaggg    300

gtttttgttg tgactgctgc cttgtataca tttattttct ttcttggaac tgggcctcgc    360

cctcctccca ctgacatgat ggcccagtcc aaggccaatg gctcgcacta tgcgctgacc    420

gccatcggcc tggggatgct ggtccttggg gtgatcatgg ccatgtggaa cctggtaccc    480

ggcttcagcg cggccgagaa gccaacagct cagggcagca acaagaccga gccaggagga    540

agaagaggag gatgaggagg ctgcctcaag gtactatgtt cccagctacg aggaagtgat    600

gaacacaaac tactcagaag caaggggaga ggagcagaac ccgaggttga gcatctctct    660

cccgtcctat gagtcactga cggggctcga cgagaccacc cccacatcca ccagggctga    720

cgtggaggcc agccctggga acccccctga caggcagaac tctaagttgg ccaaacgact    780

gaaaccgctg aaagttcgaa ggattaaatc tgaaaagctt cacctcaaag actttaggat    840

caacctccca gacaaaaacg tccctcctcc ctcgatagag cctttgactc ctccaccgca    900

gtatgatgaa gtccaggaga aggcccccga cacccggccg cccgactgaa tggccccact    960

tgagccacgc tccctcctgt ctctcacacc tttcaccccc aagactctaa caaagccaca   1020

tgagccacag ttgagaagcg gaggggccag ctgtgcatgg agccatttgg atggcggcgg   1080

gcgggggggg attctctgta tcaggagtga ctttgttgcc ccacacagcc tcctgctgca   1140

ggtgctttgg aaagagatgc tgccttggag ctggtgaatc tgtggaccac attcaagggt   1200

gtggcacagg catcttccca tccttttcac tccgaatcgc tggcgacaca ttctcctttc   1260

cagctaggaa agggttcctc gcggctggtt tagattgtgg ttgtttgttt tgcttctact   1320

aagactgttt tgtttcaaaa aggaaacaag ttttgtgttt gctgtctacg ctggagtcct   1380

gaactgtggg tagaaaacac gacctggctt tgtagaaagg acacagggct gttttatgaa   1440

ctaagcggtg aggctcaggt ggcggctctc gcagagcccc tgatgctgtt gttctttgag   1500

ggcttaaggc ctgatgaacg taggcacgtg atgcataata gtcttcaatg gtacacttaa   1560

ctagtctctt ctgtgtaaca gcaaaaaaaa aaaaaaaaag aagaagaaag aaaactgtag   1620

gaaatgttct ttttgaaatg ccatgcaatg gagctttttg taataaaata ttttatatgt   1680

agtaca                                                              1686


<210>  5332
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  5332

Met Met Ala Gln Ser Lys Ala Asn Gly Ser His Tyr Ala Leu Thr Ala 
1               5                   10                  15      


Ile Gly Leu Gly Met Leu Val Leu Gly Val Ile Met Ala Met Trp Asn 
            20                  25                  30          


Leu Val Pro Gly Phe Ser Ala Ala Glu Lys Pro Thr Ala Gln Gly Ser 
        35                  40                  45              


Asn Lys Thr Glu Pro Gly Gly Arg Arg Gly Gly 
    50                  55                  


<210>  5333
<211>  5783
<212>  DNA
<213>  Homosapiens

<400>  5333
aaaattctct ctcatcccct tgggattcaa agctgagaag atgtaaggac tggagctgca     60

gcagtctttc tgggaccatt atacagagat tctgtctgag gttggatcca cgtggtcaaa    120

agtattgctg aggagccaga gagagactga ggtctgatga catcacttga gccctgcaga    180

cttttcattt acgggaaaac agagaggatg aaggcctatc taaagagcgc agaaggcttt    240

tttgtcctaa ataaaagtac cacaattgga aggcatgaaa attcagacct tgttttacag    300

tctcctgaca tcgacaacca ccatgcactc attgaatata acgaggcgga gtgcagcttt    360

gttctccagg acttcaattc ccgcaacggc acgtttgtca acgagtgcca cattcaaaac    420

gtggctgtga agctcatccc tggagacatc ctgagatttg ggtctgcagg gctgacctat    480

gaactggtca ttgaaaatcc acctccggtg agtccgggcc actgggggat agaggggcca    540

tgtcgccttc gtgcagcccg gcgctcggat gcagctgcag ggtggcgctt atccacattg    600

gtctctttcc catggatgag gggcccagca ccatggccag ggccacagcc acctcgtgcc    660

acacagcagc caaaccaggc ccccccacca tcacatatcc ccttccacca aggtgtccag    720

ccagcaccga tgcaaaggag ctggtcccag gcctttccca gacccaccgt ggtcctgccg    780

gcctcccaca ggcggcctgt gagcgccaac aaggagatgt tctcgttcgt ggtggacgac    840

gcccgcaagc cacccgtcat caagcaagtg tggaccaatg ccatgaaact gtcagaaaaa    900

tcagtggccg aggggattcc tggggcagtt ccccctgcgg agatttatgt ggaggaggac    960

ttggcccagc aggacaagga tgaaataatt ctgctgctgg gaaaagaggt cagccgtctc   1020

tcagattatg aaattgaatc caaatacaaa gacgtcataa tagcaaacct gcagaatgaa   1080

gtggctgagc tgagtcagaa ggtgtcagag accaccacct ccaggcagaa tgagaaggag   1140

atctcgcaga agtgtcaggt tctggatgaa gacatcgatg ccaaacagaa agagatccag   1200

agcttgaaaa gccagatcag tgccctacag aaaggctaca gcaaggtgct gtgccagacc   1260

ctgtcagagc ggaactcaga aatcacatcc ctgaagaatg agggcgagaa cttaaagaga   1320

gacaacgcta tcacatcagg gatggtgtca tctttgcaaa aagacatatt agcaaaggat   1380

gagcaagttc aacaactaaa ggaagaggtc agtcacctaa aaagtcagaa caaggacaag   1440

gaccaccagc tggaagccct tggctctaga tgctcggtgc taaaggaaga gttaaaacag   1500

gaagatgctc acagggagct cagggaagcc caggagaaag agttaaaact ctgcaaaacc   1560

caaatccaag acatggagaa agaaatgaag aagcttaggg cagagctgag gaagagttgt   1620

actgaacaaa gcgtgatctc taggactctg agagaaaaaa gcaaggttga agagaagctt   1680

caggaggatt ccagaaggaa attgcttcag ctgcaagaaa tggggaacag agagagcgtc   1740

attaaaatca atttggagag ggcagtaggt cagctggagc acttcagaag tcaagtcatc   1800

aaggccacct atggacgggc gaagccgttc cgggacaagc ccgtcaccga ccaacagtta   1860

atagagaaaa ttacccaggt cactgaggac aacatcaatt ttcagcagaa aaagtggacc   1920

ctccagaaag agacccagct gagcaactcc aagcaggagg agaccaccga gaacatcgag   1980

aagctgagga cgtcgctgga cagctgccag gcttgcatga aaatatcctg ttgcagccat   2040

gacctgaaga aggaggtcga ccttcttcag cacctccagg tgagcccacc tgtctcgggg   2100

ctccagaagg tggtgctgga cgtcctgagg cacgcgctgt cctggctgga ggaggtggag   2160

cagctcctcc gggacctcgg gatcctgccc tccagcccca acaaagggtt ctctttgtat   2220

ctgatatatc ttctggaaca ttataaaaaa cttatgagcc aggcccagga acttcagatc   2280

aagttcaaca gttctcagga aactcagcag tctttactgc aggaaaagct gcgggagcat   2340

ctggcagaga aggagaagct gaacgaggag aggctagagc aagaggagaa gctcaaagcc   2400

aaaatcaggc aactgacgga agagaaggcg gctttggagg agtacattac tcaagagaga   2460

aacagagcga aagagacttt agaggaagaa cggaagagaa tgcaagaact ggagagcctc   2520

ctggcccagc agaagaaggc tttggcgaaa agcattaccc aggagaagaa cagagtgaag   2580

gaagcattag aggaagagca gacaagagtc caagagctgg aggaacgctt ggcccgccag   2640

aaggagatct cagagagcaa cattgcgtac gagaaacgca aagcaaagga ggccatggag   2700

aaggaaaaga aaaaggtgca agacctggag aatcgcttaa ccaagcagaa agaggaatta   2760

gaattaaaag agcaaaaaga ggacgtttta aataataaat taagtgacgc actggccatg   2820

gttgaagaga ctcagaaaac aaaggcaact gaaagtctaa aagcagagag cctcgccttg   2880

aaattaaatg aaacattagc cgaactggaa actaccaaga caaaaatgat catggtggaa   2940

gagcggctaa tcctgcagca gaagatggta aaggccctcc aggatgagca ggaatcacag   3000

agacacgggt ttgaagaaga gatcatggaa tataaggagc aaatcaaaca gcacgcccag   3060

acaattgtga gcctcgaaga gaaactccag aaagtcactc agcaccataa aaaaatagaa   3120

ggcgagattg caacattgaa ggacaatgac ccagccccaa aggaggaaag gccgcaagac   3180

cctctggtgg ctcccatgac agagagcagt gccaaagaca tggcgtacga acatctgata   3240

gatgacttat tggctgctca gaaggaaatt ctgtctcagc aggaagtcat catgaagtta   3300

aggaaagacc ttaccgaagc ccacagcaga atgtcggatt tgagagggga gctaaacgag   3360

aagcagaaga tggaactgga gcagaacgtg gtgctggtcc agcagcagag caaggagctg   3420

agtgtgctca aggagaagat ggcccagatg agcagcctgg tagaaaagaa agatcgggag   3480

ctgaaggccc ttgaggaggc actcagggct tcccaagaga aacacagact ccagctgaac   3540

acagagaagg aacagaagcc ccggaagaag acccagacgt gtgacacctc tgtgcagata   3600

gaacccgtcc acactgaggc cttctccagc agccaagagc agcaatcctt cagcgatcta   3660

ggggtcaggt gcaaagggtc ccggcacgag gaggtcattc agcgtcagaa aaaggcctta   3720

tctgaacttc gagcgcgaat taaagaactc gagaaggcgc gctcaccaga tcataaagac   3780

caccagaatg aatcatttct agatttaaag aacctcagaa tggaaaacaa tgtccagaaa   3840

atactactgg atgcaaaacc ggatttgcca actctctcaa gaatagagat cctagcgcct   3900

cagaatggcc tttgcaacgc aaggttcggc tcagccatgg agaagtcagg gaagatggat   3960

gtggctgagg ctttagagct cagtgaaaag ctgtacctgg atatgagcaa aaccctcgga   4020

agtctcatga acatcaagaa tatgtcaggc cacgtgtcca tgaaatacct ctcccgccag   4080

gagagggaga aggtcaacca gcttcgacaa agggacctcg acctggtgtt tgataagatc   4140

acccaactca agaaccagct ggggaggaaa gaggagctgt tgagaggata tgaaaaggac   4200

gttgaacagc tcaggcggag caaagtgtcc attgagatgt accagtcgca ggtggcaaag   4260

ctggaggatg atatctacaa agaggccgaa gagaaggccc tgctgaagga ggccctggag   4320

cgcatggagc accagctgtg ccaggagaag aggatcaaca gggccatccg gcagcagaag   4380

tagatgggag cttccagccc ctgcctcgca gacagatggt gaggatgaaa gaatgcaggc   4440

atccctcgct atctgctgtc cactctcgct gtcgtcatac ctcaggagcc aagtgctttt   4500

ggatggtgag ggtgcttgtc ccgtctctga agcacctgcc cagggcctgg caccagccgg   4560

cggacactgc cttccccatg ctgcccatga cccatgctgc ccgtgaccca tgcaggtggt   4620

ctcctgggtg agtcctgcct cagacccggt agggtctaca cactggaaag tttccccaaa   4680

gcaagtcaca catgagcagc acccgggcgg cttccaaagc tccctgaaag ctggcagagg   4740

ggctttcctg tctgctttgc agttgacata ttcatcatcc actcctgcag tccacaaggc   4800

actggaacag tgacctctaa atagagccag actctccctt tccttcactc ttgcctaagg   4860

tggagcagat cccaaggctg gggttaggca agtcagggaa agaaccacag tcactgtttc   4920

ttcatgaccg tctccaggcc agggactggg ctcacctgag ctttgcagcc gtgatagggc   4980

ttattaatgc ctctaatagc cctgcctggt acgatgatcc ctattttaca gatgaggaaa   5040

ctgcgcctca gagagttaag aggcgcccaa gtgcacacag cggctggtaa ggacagctgg   5100

gacctgaccc cagatccctc tgaccctggt tctcctgctg tctgcagggt tggccgtgag   5160

tcccctcctt gtaactgtca gcttttatgt gtgtgtgcat tctcgtgtgt gtgtacattc   5220

tcatgtgtgt gtgtgtgtgc acatgtgtac catgtgcatg agggtttggc tgtgtgtgac   5280

actatgtgtg tgtgtttgtg tgtgttgcct gcctgagctc agagagagcc aaacccccag   5340

agaagggtgc cccctccacc aaccaggtga gctccttgca gaggcctggc cttcatccca   5400

caaaccttgc agaccacagg ctccctggct tgcagccccc aaaaatgaag gcagcgctct   5460

gctctggacg tggcctttcc agcactcacc actctgaatt aaacatcaca ggcccccatc   5520

tgcacatgtc gtggggctgc ctcgggcaga ggaccgtttc cttttacgct gtgccatgcc   5580

agggagatct gggcagcagc agagtcctga gatgtccttt gatgtaccca caggagagtt   5640

cgctccttcc cgaggcagtg tcccccaggg cttggcaggc caggcccaca gcagagacac   5700

caaaccacag aatgggacgg cagagggccc taaaaagccc attgtcatgc actggctgaa   5760

aatgaaagaa aacctgcaga ttt                                           5783


<210>  5334
<211>  1408
<212>  PRT
<213>  Homosapiens

<400>  5334

Met Thr Ser Leu Glu Pro Cys Arg Leu Phe Ile Tyr Gly Lys Thr Glu 
1               5                   10                  15      


Arg Met Lys Ala Tyr Leu Lys Ser Ala Glu Gly Phe Phe Val Leu Asn 
            20                  25                  30          


Lys Ser Thr Thr Ile Gly Arg His Glu Asn Ser Asp Leu Val Leu Gln 
        35                  40                  45              


Ser Pro Asp Ile Asp Asn His His Ala Leu Ile Glu Tyr Asn Glu Ala 
    50                  55                  60                  


Glu Cys Ser Phe Val Leu Gln Asp Phe Asn Ser Arg Asn Gly Thr Phe 
65                  70                  75                  80  


Val Asn Glu Cys His Ile Gln Asn Val Ala Val Lys Leu Ile Pro Gly 
                85                  90                  95      


Asp Ile Leu Arg Phe Gly Ser Ala Gly Leu Thr Tyr Glu Leu Val Ile 
            100                 105                 110         


Glu Asn Pro Pro Pro Val Ser Pro Gly His Trp Gly Ile Glu Gly Pro 
        115                 120                 125             


Cys Arg Leu Arg Ala Ala Arg Arg Ser Asp Ala Ala Ala Gly Trp Arg 
    130                 135                 140                 


Leu Ser Thr Leu Val Ser Phe Pro Trp Met Arg Gly Pro Ala Pro Trp 
145                 150                 155                 160 


Pro Gly Pro Gln Pro Pro Arg Ala Thr Gln Gln Pro Asn Gln Ala Pro 
                165                 170                 175     


Pro Pro Ser His Ile Pro Phe His Gln Gly Val Gln Pro Ala Pro Met 
            180                 185                 190         


Gln Arg Ser Trp Ser Gln Ala Phe Pro Arg Pro Thr Val Val Leu Pro 
        195                 200                 205             


Ala Ser His Arg Arg Pro Val Ser Ala Asn Lys Glu Met Phe Ser Phe 
    210                 215                 220                 


Val Val Asp Asp Ala Arg Lys Pro Pro Val Ile Lys Gln Val Trp Thr 
225                 230                 235                 240 


Asn Ala Met Lys Leu Ser Glu Lys Ser Val Ala Glu Gly Ile Pro Gly 
                245                 250                 255     


Ala Val Pro Pro Ala Glu Ile Tyr Val Glu Glu Asp Leu Ala Gln Gln 
            260                 265                 270         


Asp Lys Asp Glu Ile Ile Leu Leu Leu Gly Lys Glu Val Ser Arg Leu 
        275                 280                 285             


Ser Asp Tyr Glu Ile Glu Ser Lys Tyr Lys Asp Val Ile Ile Ala Asn 
    290                 295                 300                 


Leu Gln Asn Glu Val Ala Glu Leu Ser Gln Lys Val Ser Glu Thr Thr 
305                 310                 315                 320 


Thr Ser Arg Gln Asn Glu Lys Glu Ile Ser Gln Lys Cys Gln Val Leu 
                325                 330                 335     


Asp Glu Asp Ile Asp Ala Lys Gln Lys Glu Ile Gln Ser Leu Lys Ser 
            340                 345                 350         


Gln Ile Ser Ala Leu Gln Lys Gly Tyr Ser Lys Val Leu Cys Gln Thr 
        355                 360                 365             


Leu Ser Glu Arg Asn Ser Glu Ile Thr Ser Leu Lys Asn Glu Gly Glu 
    370                 375                 380                 


Asn Leu Lys Arg Asp Asn Ala Ile Thr Ser Gly Met Val Ser Ser Leu 
385                 390                 395                 400 


Gln Lys Asp Ile Leu Ala Lys Asp Glu Gln Val Gln Gln Leu Lys Glu 
                405                 410                 415     


Glu Val Ser His Leu Lys Ser Gln Asn Lys Asp Lys Asp His Gln Leu 
            420                 425                 430         


Glu Ala Leu Gly Ser Arg Cys Ser Val Leu Lys Glu Glu Leu Lys Gln 
        435                 440                 445             


Glu Asp Ala His Arg Glu Leu Arg Glu Ala Gln Glu Lys Glu Leu Lys 
    450                 455                 460                 


Leu Cys Lys Thr Gln Ile Gln Asp Met Glu Lys Glu Met Lys Lys Leu 
465                 470                 475                 480 


Arg Ala Glu Leu Arg Lys Ser Cys Thr Glu Gln Ser Val Ile Ser Arg 
                485                 490                 495     


Thr Leu Arg Glu Lys Ser Lys Val Glu Glu Lys Leu Gln Glu Asp Ser 
            500                 505                 510         


Arg Arg Lys Leu Leu Gln Leu Gln Glu Met Gly Asn Arg Glu Ser Val 
        515                 520                 525             


Ile Lys Ile Asn Leu Glu Arg Ala Val Gly Gln Leu Glu His Phe Arg 
    530                 535                 540                 


Ser Gln Val Ile Lys Ala Thr Tyr Gly Arg Ala Lys Pro Phe Arg Asp 
545                 550                 555                 560 


Lys Pro Val Thr Asp Gln Gln Leu Ile Glu Lys Ile Thr Gln Val Thr 
                565                 570                 575     


Glu Asp Asn Ile Asn Phe Gln Gln Lys Lys Trp Thr Leu Gln Lys Glu 
            580                 585                 590         


Thr Gln Leu Ser Asn Ser Lys Gln Glu Glu Thr Thr Glu Asn Ile Glu 
        595                 600                 605             


Lys Leu Arg Thr Ser Leu Asp Ser Cys Gln Ala Cys Met Lys Ile Ser 
    610                 615                 620                 


Cys Cys Ser His Asp Leu Lys Lys Glu Val Asp Leu Leu Gln His Leu 
625                 630                 635                 640 


Gln Val Ser Pro Pro Val Ser Gly Leu Gln Lys Val Val Leu Asp Val 
                645                 650                 655     


Leu Arg His Ala Leu Ser Trp Leu Glu Glu Val Glu Gln Leu Leu Arg 
            660                 665                 670         


Asp Leu Gly Ile Leu Pro Ser Ser Pro Asn Lys Gly Phe Ser Leu Tyr 
        675                 680                 685             


Leu Ile Tyr Leu Leu Glu His Tyr Lys Lys Leu Met Ser Gln Ala Gln 
    690                 695                 700                 


Glu Leu Gln Ile Lys Phe Asn Ser Ser Gln Glu Thr Gln Gln Ser Leu 
705                 710                 715                 720 


Leu Gln Glu Lys Leu Arg Glu His Leu Ala Glu Lys Glu Lys Leu Asn 
                725                 730                 735     


Glu Glu Arg Leu Glu Gln Glu Glu Lys Leu Lys Ala Lys Ile Arg Gln 
            740                 745                 750         


Leu Thr Glu Glu Lys Ala Ala Leu Glu Glu Tyr Ile Thr Gln Glu Arg 
        755                 760                 765             


Asn Arg Ala Lys Glu Thr Leu Glu Glu Glu Arg Lys Arg Met Gln Glu 
    770                 775                 780                 


Leu Glu Ser Leu Leu Ala Gln Gln Lys Lys Ala Leu Ala Lys Ser Ile 
785                 790                 795                 800 


Thr Gln Glu Lys Asn Arg Val Lys Glu Ala Leu Glu Glu Glu Gln Thr 
                805                 810                 815     


Arg Val Gln Glu Leu Glu Glu Arg Leu Ala Arg Gln Lys Glu Ile Ser 
            820                 825                 830         


Glu Ser Asn Ile Ala Tyr Glu Lys Arg Lys Ala Lys Glu Ala Met Glu 
        835                 840                 845             


Lys Glu Lys Lys Lys Val Gln Asp Leu Glu Asn Arg Leu Thr Lys Gln 
    850                 855                 860                 


Lys Glu Glu Leu Glu Leu Lys Glu Gln Lys Glu Asp Val Leu Asn Asn 
865                 870                 875                 880 


Lys Leu Ser Asp Ala Leu Ala Met Val Glu Glu Thr Gln Lys Thr Lys 
                885                 890                 895     


Ala Thr Glu Ser Leu Lys Ala Glu Ser Leu Ala Leu Lys Leu Asn Glu 
            900                 905                 910         


Thr Leu Ala Glu Leu Glu Thr Thr Lys Thr Lys Met Ile Met Val Glu 
        915                 920                 925             


Glu Arg Leu Ile Leu Gln Gln Lys Met Val Lys Ala Leu Gln Asp Glu 
    930                 935                 940                 


Gln Glu Ser Gln Arg His Gly Phe Glu Glu Glu Ile Met Glu Tyr Lys 
945                 950                 955                 960 


Glu Gln Ile Lys Gln His Ala Gln Thr Ile Val Ser Leu Glu Glu Lys 
                965                 970                 975     


Leu Gln Lys Val Thr Gln His His Lys Lys Ile Glu Gly Glu Ile Ala 
            980                 985                 990         


Thr Leu Lys Asp Asn Asp Pro Ala  Pro Lys Glu Glu Arg  Pro Gln Asp 
        995                 1000                 1005             


Pro Leu  Val Ala Pro Met Thr  Glu Ser Ser Ala Lys  Asp Met Ala 
    1010                 1015                 1020             


Tyr Glu  His Leu Ile Asp Asp  Leu Leu Ala Ala Gln  Lys Glu Ile 
    1025                 1030                 1035             


Leu Ser  Gln Gln Glu Val Ile  Met Lys Leu Arg Lys  Asp Leu Thr 
    1040                 1045                 1050             


Glu Ala  His Ser Arg Met Ser  Asp Leu Arg Gly Glu  Leu Asn Glu 
    1055                 1060                 1065             


Lys Gln  Lys Met Glu Leu Glu  Gln Asn Val Val Leu  Val Gln Gln 
    1070                 1075                 1080             


Gln Ser  Lys Glu Leu Ser Val  Leu Lys Glu Lys Met  Ala Gln Met 
    1085                 1090                 1095             


Ser Ser  Leu Val Glu Lys Lys  Asp Arg Glu Leu Lys  Ala Leu Glu 
    1100                 1105                 1110             


Glu Ala  Leu Arg Ala Ser Gln  Glu Lys His Arg Leu  Gln Leu Asn 
    1115                 1120                 1125             


Thr Glu  Lys Glu Gln Lys Pro  Arg Lys Lys Thr Gln  Thr Cys Asp 
    1130                 1135                 1140             


Thr Ser  Val Gln Ile Glu Pro  Val His Thr Glu Ala  Phe Ser Ser 
    1145                 1150                 1155             


Ser Gln  Glu Gln Gln Ser Phe  Ser Asp Leu Gly Val  Arg Cys Lys 
    1160                 1165                 1170             


Gly Ser  Arg His Glu Glu Val  Ile Gln Arg Gln Lys  Lys Ala Leu 
    1175                 1180                 1185             


Ser Glu  Leu Arg Ala Arg Ile  Lys Glu Leu Glu Lys  Ala Arg Ser 
    1190                 1195                 1200             


Pro Asp  His Lys Asp His Gln  Asn Glu Ser Phe Leu  Asp Leu Lys 
    1205                 1210                 1215             


Asn Leu  Arg Met Glu Asn Asn  Val Gln Lys Ile Leu  Leu Asp Ala 
    1220                 1225                 1230             


Lys Pro  Asp Leu Pro Thr Leu  Ser Arg Ile Glu Ile  Leu Ala Pro 
    1235                 1240                 1245             


Gln Asn  Gly Leu Cys Asn Ala  Arg Phe Gly Ser Ala  Met Glu Lys 
    1250                 1255                 1260             


Ser Gly  Lys Met Asp Val Ala  Glu Ala Leu Glu Leu  Ser Glu Lys 
    1265                 1270                 1275             


Leu Tyr  Leu Asp Met Ser Lys  Thr Leu Gly Ser Leu  Met Asn Ile 
    1280                 1285                 1290             


Lys Asn  Met Ser Gly His Val  Ser Met Lys Tyr Leu  Ser Arg Gln 
    1295                 1300                 1305             


Glu Arg  Glu Lys Val Asn Gln  Leu Arg Gln Arg Asp  Leu Asp Leu 
    1310                 1315                 1320             


Val Phe  Asp Lys Ile Thr Gln  Leu Lys Asn Gln Leu  Gly Arg Lys 
    1325                 1330                 1335             


Glu Glu  Leu Leu Arg Gly Tyr  Glu Lys Asp Val Glu  Gln Leu Arg 
    1340                 1345                 1350             


Arg Ser  Lys Val Ser Ile Glu  Met Tyr Gln Ser Gln  Val Ala Lys 
    1355                 1360                 1365             


Leu Glu  Asp Asp Ile Tyr Lys  Glu Ala Glu Glu Lys  Ala Leu Leu 
    1370                 1375                 1380             


Lys Glu  Ala Leu Glu Arg Met  Glu His Gln Leu Cys  Gln Glu Lys 
    1385                 1390                 1395             


Arg Ile  Asn Arg Ala Ile Arg  Gln Gln Lys 
    1400                 1405             


<210>  5335
<211>  2424
<212>  DNA
<213>  Homosapiens

<400>  5335
gggtgcgagc tggagactcc gcgggagcgc ggccgggagg cttcgccccg gagctggccc     60

gacgcctccc gagctggcag ggctctcggc ggaggtcgga gcgtgggctt cctcctcccg    120

ccagggaaaa cagagaggat gaaggcctat ctaaagagcg cagaaggctt ttttgtccta    180

aataaaagta ccacaattgg aaggcatgaa aattcagacc ttgttttaca gtctcctgac    240

atcgacaacc accatgcact cattgaatat aacgaggcgg agtgcagctt tgttctccag    300

gacttcaatt cccgcaacgg cacgtttgtc aacgagtgcc acattcaaaa cgtggctgtg    360

aagctcatcc ctggagacat cctgagattt gggtctgcag ggctgaccta tgaactggtc    420

attgaaaatc cacctccggt ctctttccca tggatgaggg gcccagcacc atggccaggg    480

ccacagccac ctcgtgccac acagcagcca aaccaggccc ccccaccatc acatatcccc    540

ttccaccaag gtgtccagcc agcaccgatg caaaggagct ggtcccaggc ctttcccaga    600

cccaccgtgg tcctgccggc ctcccacagg cggcctgtga gcgccaacaa ggagatgttc    660

tcgttcgtgg tggacgacgc ccgcaagcca cccgtcatca agcaaggcct cagggaaact    720

catgatgtct tttgtgctct ctgctgatct cacgccttag tgtggaccaa tgccatgaaa    780

ctgtcagaaa aatcagtggc cgaggggatt cctggggcag ttccccctgc ggagatttat    840

gtggaggagg acttggccca gcaggacaag atcagtgccc tacagaaagg ctacagcaag    900

gtgctgtgcc agaccctgtc agagcggaac tcagaaatca catccctgaa gaatgagggc    960

gagaacttaa agagagacaa cgctatcaca tcagggatgg tgtcatcttt gcaaaaagac   1020

atattagcaa aggatgagca agttcaacaa ctaaaggaag aggtcagtca cctaaaaagt   1080

cagaacaagg acaaggacca ccagctggaa gcccttggct ctagatgctc ggtgctaaag   1140

gaagagttaa aacaggaaga tgctcacagg gagctcaggg aagcccagga gaaagagtta   1200

aaactctgca aaacccaaat ccaagacatg gagaaagaaa tgaagaagct tagggcagag   1260

ctgaggaaga gttgtactga acaaagcgtg atctctagga ctctgagaga aaaaagcaag   1320

ctggagcact tcagaagtca agtcatcaag gccacctatg gacgggcgaa gccgttccgg   1380

gacaagcccg tcaccgacca acagttaata gagaaaatta cccaggtcac tgaggacaac   1440

atcaattttc agcagaaaaa gtggaccctc cagaaagaga cccagctgag caactccaag   1500

caggaggaga ccaccgagaa catcgagaag ctgaggacgt cgctggacag ctgccaggct   1560

tgcatgaaaa tatcctgttg cagccatgac ctgaagaagg aggtcgacct tcttcagcac   1620

ctccaggtga gcccacctgt ctcggggctc cagaaggtgg tgctggacgt cctgaggcac   1680

gcgctgtcct ggctggagga ggtggagcag ctcctccggg acctcgggat cctgccctcc   1740

agccccaaca aagggttctc tttgtatctg atatatcttc tggaacatta taaaaaactt   1800

atgagccagg cccaggaact tcagatcaag ttcaacagtt ctcaggaaac tcagcagtct   1860

ttactgcagg aaaagctgcg ggagcatctg gcagagaagg agaagctgaa cgaggagagg   1920

ctagagcaag aggagaagct caaagccaaa atcaggcaac tgacggaaga gaaggcggct   1980

ttggaggagt acattactca agagagaaac agagcgaaag agactttaga ggaagaacgg   2040

aagagaatgc aagaactgga gagcctcctg gcccagcaga agaaggcttt ggcgaaaagc   2100

attacccagt ggaaagtact agagaaacct cgtcccacca ggcctcatgt gatcctctac   2160

cagaagctgg agcagccacc ttggggatca gcagacacca gcagcaggcc aaaggatagt   2220

ggagtggagg gacaagaagg cctgggtgag ccttctctga gaatcactga gctctgaacc   2280

atgaatgaac tgcctacctc tgtacttcct gttgtatagg acaaagaaat ccctatctat   2340

ttaaaccact gtagtcaggt ctatgtattt gtgctgtgga acaaaccacc caaactgagt   2400

gacttaaaat gacaaatatt tatt                                          2424


<210>  5336
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  5336

Met Lys Leu Ser Glu Lys Ser Val Ala Glu Gly Ile Pro Gly Ala Val 
1               5                   10                  15      


Pro Pro Ala Glu Ile Tyr Val Glu Glu Asp Leu Ala Gln Gln Asp Lys 
            20                  25                  30          


Ile Ser Ala Leu Gln Lys Gly Tyr Ser Lys Val Leu Cys Gln Thr Leu 
        35                  40                  45              


Ser Glu Arg Asn Ser Glu Ile Thr Ser Leu Lys Asn Glu Gly Glu Asn 
    50                  55                  60                  


Leu Lys Arg Asp Asn Ala Ile Thr Ser Gly Met Val Ser Ser Leu Gln 
65                  70                  75                  80  


Lys Asp Ile Leu Ala Lys Asp Glu Gln Val Gln Gln Leu Lys Glu Glu 
                85                  90                  95      


Val Ser His Leu Lys Ser Gln Asn Lys Asp Lys Asp His Gln Leu Glu 
            100                 105                 110         


Ala Leu Gly Ser Arg Cys Ser Val Leu Lys Glu Glu Leu Lys Gln Glu 
        115                 120                 125             


Asp Ala His Arg Glu Leu Arg Glu Ala Gln Glu Lys Glu Leu Lys Leu 
    130                 135                 140                 


Cys Lys Thr Gln Ile Gln Asp Met Glu Lys Glu Met Lys Lys Leu Arg 
145                 150                 155                 160 


Ala Glu Leu Arg Lys Ser Cys Thr Glu Gln Ser Val Ile Ser Arg Thr 
                165                 170                 175     


Leu Arg Glu Lys Ser Lys Leu Glu His Phe Arg Ser Gln Val Ile Lys 
            180                 185                 190         


Ala Thr Tyr Gly Arg Ala Lys Pro Phe Arg Asp Lys Pro Val Thr Asp 
        195                 200                 205             


Gln Gln Leu Ile Glu Lys Ile Thr Gln Val Thr Glu Asp Asn Ile Asn 
    210                 215                 220                 


Phe Gln Gln Lys Lys Trp Thr Leu Gln Lys Glu Thr Gln Leu Ser Asn 
225                 230                 235                 240 


Ser Lys Gln Glu Glu Thr Thr Glu Asn Ile Glu Lys Leu Arg Thr Ser 
                245                 250                 255     


Leu Asp Ser Cys Gln Ala Cys Met Lys Ile Ser Cys Cys Ser His Asp 
            260                 265                 270         


Leu Lys Lys Glu Val Asp Leu Leu Gln His Leu Gln Val Ser Pro Pro 
        275                 280                 285             


Val Ser Gly Leu Gln Lys Val Val Leu Asp Val Leu Arg His Ala Leu 
    290                 295                 300                 


Ser Trp Leu Glu Glu Val Glu Gln Leu Leu Arg Asp Leu Gly Ile Leu 
305                 310                 315                 320 


Pro Ser Ser Pro Asn Lys Gly Phe Ser Leu Tyr Leu Ile Tyr Leu Leu 
                325                 330                 335     


Glu His Tyr Lys Lys Leu Met Ser Gln Ala Gln Glu Leu Gln Ile Lys 
            340                 345                 350         


Phe Asn Ser Ser Gln Glu Thr Gln Gln Ser Leu Leu Gln Glu Lys Leu 
        355                 360                 365             


Arg Glu His Leu Ala Glu Lys Glu Lys Leu Asn Glu Glu Arg Leu Glu 
    370                 375                 380                 


Gln Glu Glu Lys Leu Lys Ala Lys Ile Arg Gln Leu Thr Glu Glu Lys 
385                 390                 395                 400 


Ala Ala Leu Glu Glu Tyr Ile Thr Gln Glu Arg Asn Arg Ala Lys Glu 
                405                 410                 415     


Thr Leu Glu Glu Glu Arg Lys Arg Met Gln Glu Leu Glu Ser Leu Leu 
            420                 425                 430         


Ala Gln Gln Lys Lys Ala Leu Ala Lys Ser Ile Thr Gln Trp Lys Val 
        435                 440                 445             


Leu Glu Lys Pro Arg Pro Thr Arg Pro His Val Ile Leu Tyr Gln Lys 
    450                 455                 460                 


Leu Glu Gln Pro Pro Trp Gly Ser Ala Asp Thr Ser Ser Arg Pro Lys 
465                 470                 475                 480 


Asp Ser Gly Val Glu Gly Gln Glu Gly Leu Gly Glu Pro Ser Leu Arg 
                485                 490                 495     


Ile Thr Glu Leu 
            500 


<210>  5337
<211>  530
<212>  DNA
<213>  Homosapiens

<400>  5337
aatgagtgag gcaagacagc cctgaggatg gggaaggaca tgatggacgg agaagtcagc     60

ccagggcagg ggcacagtgg ctcagcttct gaaaccaaag aatggaaaag agggtctctt    120

tcccatggat gaggggccca gcaccatggc cagggccaca gccacctcgt gccacacagc    180

agccaaacca ggccccccca ccatcacata tccccttcca ccaaggtgtc cagccagcac    240

cgatgcaaag gagctggtcc caggcctttc ccagacccac cgtggtcctg ccggcctccc    300

acaggcggcc tgtgagcgcc aacaaggaga tgttctcgtt cgtggtggac gacgcccgca    360

agccacccgt catcaagcaa ggtatgcgtc agggctgcca ttggtggctt gggggtggtt    420

cacggccatg tggatgggtc ttggttttgg tttactttct gattctaaaa gtagaacata    480

ttcaattgta aaaaatgaaa ataaattcag gataagcaga aagtaagaaa               530


<210>  5338
<211>  129
<212>  PRT
<213>  Homosapiens

<400>  5338

Met Glu Lys Arg Val Ser Phe Pro Trp Met Arg Gly Pro Ala Pro Trp 
1               5                   10                  15      


Pro Gly Pro Gln Pro Pro Arg Ala Thr Gln Gln Pro Asn Gln Ala Pro 
            20                  25                  30          


Pro Pro Ser His Ile Pro Phe His Gln Gly Val Gln Pro Ala Pro Met 
        35                  40                  45              


Gln Arg Ser Trp Ser Gln Ala Phe Pro Arg Pro Thr Val Val Leu Pro 
    50                  55                  60                  


Ala Ser His Arg Arg Pro Val Ser Ala Asn Lys Glu Met Phe Ser Phe 
65                  70                  75                  80  


Val Val Asp Asp Ala Arg Lys Pro Pro Val Ile Lys Gln Gly Met Arg 
                85                  90                  95      


Gln Gly Cys His Trp Trp Leu Gly Gly Gly Ser Arg Pro Cys Gly Trp 
            100                 105                 110         


Val Leu Val Leu Val Tyr Phe Leu Ile Leu Lys Val Glu His Ile Gln 
        115                 120                 125             


Leu 
    


<210>  5339
<211>  1889
<212>  DNA
<213>  Homosapiens

<400>  5339
taagaagtgc ttttcgcctc ccaccatgat tctgaggcct ccccggccat gtggaactat     60

cagtgcccta cagaaaggct acagcaaggt gctgtgccag accctgtcag agcggaactc    120

agaaatcaca tccctgaaga atgagggcga gaacttaaag agagacaacg ctatcacatc    180

agggatggtg tcatctttgc aaaaagacat attagcaaag gatgagcaag ttcaacaact    240

aaaggaagag gtcagtcacc taaaaagtca gaacaaggac aaggaccacc agctggaagc    300

ccttggctct agatgctcgg tgctaaagga agagttaaaa caggaagatg ctcacaggga    360

gctcagggaa gcccaggaga aagagttaaa actctgcaaa acccaaatcc aagacatgga    420

gaaagaaatg aagaagctta gggcagagct gaggaagagt tgtactgaac aaagcgtgat    480

ctctaggact ctgagagaaa aaagcaagct ggagcacttc agaagtcaag tcatcaaggc    540

cacctatgga cgggcgaagc cgttccggga caagcccgtc accgaccaac agttaataga    600

gaaaattacc caggtcactg aggacaacat caattttcag cagaaaaagt ggaccctcca    660

gaaagagacc cagctgagca actccaagca ggaggagacc accgagaaca tcgagaagct    720

gaggacgtcg ctggacagct gccaggcttg catgaaaata tcctgttgca gccatgacct    780

gaagaaggag gtcgaccttc ttcagcacct ccaggtgagc ccacctgtct cggggctcca    840

gaaggtggtg ctggacgtcc tgaggcacgc gctgtcctgg ctggaggagg tggagcagct    900

cctccgggac ctcgggatcc tgccctccag ccccaacaaa ggttactggg actttttttc    960

tcacatggtt gcatgactct aaaatgtcgc gttgaatctc agcatgatgg gacatctgtt   1020

gaggaagtct tcctgggtat ctggccaagt ctattccctt ctccagaacc ccctgcttct   1080

ctgcttgagg cgtaattttc cattaaaaaa aaaaacacac acatacaagt gagacacgat   1140

aactgaagaa aaatgaaaca aaacagaggc aaaaggaaaa ttaaatcgaa attatgcaaa   1200

gtctaattac gctgtttaac ctccaaggca ttttcccatg gaaataaccg cgtgattcca   1260

ggcaagtgac ttaccctgtc tatgcctcag tttccctatc tgtaaaatga ggctaatagg   1320

gagtacccac cctttagggc tgttgtgatc attaaaatgc atgaatatat ggaaagtact   1380

tggaatagta cctggcacac aataggcatt actgaatgtt tattgacttt taatttgaca   1440

aaaaaatagt gtcacgttac cctcgatttt ctttggttta ttcctaatgg tacgtcatcc   1500

atgtcagtag acacagacct acatcatcgc tgttaccgac ggcagttact gattccattg   1560

tgtaggatgt gccattgttt tagacaatcc cctatcatgg gcacttaggt gatttccagt   1620

ttttcacact cataaatcat gctgggatga acattgttgc acacatacct gctcatatta   1680

tctttattct cctagaggtg gagaggtatg aatcactttc tttcaacaaa tagtgattgc   1740

atgcatgctt accagaggcc acatgttgtg cagggcagag acgtaacggg gtcaggaaca   1800

ggtagaatca ggtcatgggt atatggttca ctgtaaaatt cttccaatat gtccatacat   1860

ttgaaatttt ttataataaa atactgggg                                     1889


<210>  5340
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  5340

Met Ile Leu Arg Pro Pro Arg Pro Cys Gly Thr Ile Ser Ala Leu Gln 
1               5                   10                  15      


Lys Gly Tyr Ser Lys Val Leu Cys Gln Thr Leu Ser Glu Arg Asn Ser 
            20                  25                  30          


Glu Ile Thr Ser Leu Lys Asn Glu Gly Glu Asn Leu Lys Arg Asp Asn 
        35                  40                  45              


Ala Ile Thr Ser Gly Met Val Ser Ser Leu Gln Lys Asp Ile Leu Ala 
    50                  55                  60                  


Lys Asp Glu Gln Val Gln Gln Leu Lys Glu Glu Val Ser His Leu Lys 
65                  70                  75                  80  


Ser Gln Asn Lys Asp Lys Asp His Gln Leu Glu Ala Leu Gly Ser Arg 
                85                  90                  95      


Cys Ser Val Leu Lys Glu Glu Leu Lys Gln Glu Asp Ala His Arg Glu 
            100                 105                 110         


Leu Arg Glu Ala Gln Glu Lys Glu Leu Lys Leu Cys Lys Thr Gln Ile 
        115                 120                 125             


Gln Asp Met Glu Lys Glu Met Lys Lys Leu Arg Ala Glu Leu Arg Lys 
    130                 135                 140                 


Ser Cys Thr Glu Gln Ser Val Ile Ser Arg Thr Leu Arg Glu Lys Ser 
145                 150                 155                 160 


Lys Leu Glu His Phe Arg Ser Gln Val Ile Lys Ala Thr Tyr Gly Arg 
                165                 170                 175     


Ala Lys Pro Phe Arg Asp Lys Pro Val Thr Asp Gln Gln Leu Ile Glu 
            180                 185                 190         


Lys Ile Thr Gln Val Thr Glu Asp Asn Ile Asn Phe Gln Gln Lys Lys 
        195                 200                 205             


Trp Thr Leu Gln Lys Glu Thr Gln Leu Ser Asn Ser Lys Gln Glu Glu 
    210                 215                 220                 


Thr Thr Glu Asn Ile Glu Lys Leu Arg Thr Ser Leu Asp Ser Cys Gln 
225                 230                 235                 240 


Ala Cys Met Lys Ile Ser Cys Cys Ser His Asp Leu Lys Lys Glu Val 
                245                 250                 255     


Asp Leu Leu Gln His Leu Gln Val Ser Pro Pro Val Ser Gly Leu Gln 
            260                 265                 270         


Lys Val Val Leu Asp Val Leu Arg His Ala Leu Ser Trp Leu Glu Glu 
        275                 280                 285             


Val Glu Gln Leu Leu Arg Asp Leu Gly Ile Leu Pro Ser Ser Pro Asn 
    290                 295                 300                 


Lys Gly Tyr Trp Asp Phe Phe Ser His Met Val Ala 
305                 310                 315     


<210>  5341
<211>  1676
<212>  DNA
<213>  Homosapiens

<400>  5341
tcccaccatg attctgaggc ctccccggcc atgtggaact atcagtgccc tacagaaagg     60

ctacagcaag gtgctgtgcc agaccctgtc agagcggaac tcagaaatca catccctgaa    120

gaatgagggc gagaacttaa agagagacaa cgctatcaca tcagggatgg tgtcatcttt    180

gcaaaaagac atattagcaa aggatgagca agttcaacaa ctaaaggaag aggtcagtca    240

cctaaaaagt cagaacaagg acaaggacca ccagctggaa gcccttggct ctagactgga    300

gcacttcaga agtcaagtca tcaaggccac ctatggacgg gcgaagccgt tccgggacaa    360

gcccgtcacc gaccaacagt taatagagaa aattacccag gtcactgagg acaacatcaa    420

ttttcagcag aaaaagtgga ccctccagaa agagacccag ctgagcaact ccaagcagga    480

ggagaccacc gagaacatcg agaagctgag gacgtcgctg gacagctgcc aggcttgcat    540

gaaaatatcc tgttgcagcc atgacctgaa gaaggaggtc gaccttcttc agcacctcca    600

ggtgagccca cctgtctcgg ggctccagaa ggtggtgctg gacgtcctga ggcacgcgct    660

gtcctggctg gaggaggtgg agcagctcct ccgggacctc gggatcctgc cctccagccc    720

caacaaaggt tactgggact ttttttctca catggttgca tgactctaaa atgtcgcgtt    780

gaatctcagc atgatgggac atctgttgag gaagtcttcc tgggtatctg gccaagtcta    840

ttcccttctc cagaaccccc tgcttctctg cttgaggcgt aattttccat taaaaaaaaa    900

aacacacaca tacaagtgag acacgataac tgaagaaaaa tgaaacaaaa cagaggcaaa    960

aggaaaatta aatcgaaatt atgcaaagtc taattacgct gtttaacctc caaggcattt   1020

tcccatggaa ataaccgcgt gattccaggc aagtgactta ccctgtctat gcctcagttt   1080

ccctatctgt aaaatgaggc taatagggag tacccaccct ttagggctgt tgtgatcatt   1140

aaaatgcatg aatatatgga aagtacttgg aatagtacct ggcacacaat aggcattact   1200

gaatgtttat tgacttttaa tttgacaaaa aaatagtgtc acgttaccct cgattttctt   1260

tggtttattc ctaatggtac gtcatccatg tcagtagaca cagacctaca tcatcgctgt   1320

taccgacggc agttactgat tccattgtgt aggatgtgcc attgttttag acaatcccct   1380

atcatgggca cttaggtgat ttccagtttt tcacactcat aaatcatgct gggatgaaca   1440

ttgttgcaca catacctgct catattatct ttattctcct agaggtggag aggtatgaat   1500

cactttcttt caacaaatag tgattgcatg catgcttacc agaggccaca tgttgtgcag   1560

ggcagagacg taacggggtc aggaacaggt agaatcaggt catgggtata tggttcactg   1620

taaaattctt ccaatatgtc catacatttg aaatttttta taataaaata ctgggg       1676


<210>  5342
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  5342

Met Ile Leu Arg Pro Pro Arg Pro Cys Gly Thr Ile Ser Ala Leu Gln 
1               5                   10                  15      


Lys Gly Tyr Ser Lys Val Leu Cys Gln Thr Leu Ser Glu Arg Asn Ser 
            20                  25                  30          


Glu Ile Thr Ser Leu Lys Asn Glu Gly Glu Asn Leu Lys Arg Asp Asn 
        35                  40                  45              


Ala Ile Thr Ser Gly Met Val Ser Ser Leu Gln Lys Asp Ile Leu Ala 
    50                  55                  60                  


Lys Asp Glu Gln Val Gln Gln Leu Lys Glu Glu Val Ser His Leu Lys 
65                  70                  75                  80  


Ser Gln Asn Lys Asp Lys Asp His Gln Leu Glu Ala Leu Gly Ser Arg 
                85                  90                  95      


Leu Glu His Phe Arg Ser Gln Val Ile Lys Ala Thr Tyr Gly Arg Ala 
            100                 105                 110         


Lys Pro Phe Arg Asp Lys Pro Val Thr Asp Gln Gln Leu Ile Glu Lys 
        115                 120                 125             


Ile Thr Gln Val Thr Glu Asp Asn Ile Asn Phe Gln Gln Lys Lys Trp 
    130                 135                 140                 


Thr Leu Gln Lys Glu Thr Gln Leu Ser Asn Ser Lys Gln Glu Glu Thr 
145                 150                 155                 160 


Thr Glu Asn Ile Glu Lys Leu Arg Thr Ser Leu Asp Ser Cys Gln Ala 
                165                 170                 175     


Cys Met Lys Ile Ser Cys Cys Ser His Asp Leu Lys Lys Glu Val Asp 
            180                 185                 190         


Leu Leu Gln His Leu Gln Val Ser Pro Pro Val Ser Gly Leu Gln Lys 
        195                 200                 205             


Val Val Leu Asp Val Leu Arg His Ala Leu Ser Trp Leu Glu Glu Val 
    210                 215                 220                 


Glu Gln Leu Leu Arg Asp Leu Gly Ile Leu Pro Ser Ser Pro Asn Lys 
225                 230                 235                 240 


Gly Tyr Trp Asp Phe Phe Ser His Met Val Ala 
                245                 250     


<210>  5343
<211>  556
<212>  DNA
<213>  Homosapiens

<400>  5343
aacatctttg atgattcacc ctgggaagtc acattcacca cttccacagt gccatatgag     60

ttacacacgt cagccctatt cagggatggt gtcatctttg caaaaagaca tattagcaaa    120

ggatgagcaa gttcaacaac taaaggaaga ggtcagtcac ctaaaaagtc agaacaagga    180

caaggaccac cagctggaag cccttggctc tagacgaaat gggaacaaca aaatcagttt    240

tgagaagtga gaggccggtt tgcattgtgc gcttccgcct ctgcggctgg ttagcccgcc    300

tcgcccagcc ctctgcatcc gtcccccgag cagggtcacc gcctggatta catgtgttgt    360

cgccctttca ggtctgcctt cttctccagg ccgcacctgg cgttcatcag cacgtgggct    420

cctcgtgacc aagggtattg ctcatgtgaa catccgaatg actgtcttta tttttcaaat    480

tacatgtgct gtgttaattt tagaataaaa agtagataaa actggagagc aaaattaaag    540

agagaagaga aatgcc                                                    556


<210>  5344
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  5344

Met Ile His Pro Gly Lys Ser His Ser Pro Leu Pro Gln Cys His Met 
1               5                   10                  15      


Ser Tyr Thr Arg Gln Pro Tyr Ser Gly Met Val Ser Ser Leu Gln Lys 
            20                  25                  30          


Asp Ile Leu Ala Lys Asp Glu Gln Val Gln Gln Leu Lys Glu Glu Val 
        35                  40                  45              


Ser His Leu Lys Ser Gln Asn Lys Asp Lys Asp His Gln Leu Glu Ala 
    50                  55                  60                  


Leu Gly Ser Arg Arg Asn Gly Asn Asn Lys Ile Ser Phe Glu Lys 
65                  70                  75                  


<210>  5345
<211>  4405
<212>  DNA
<213>  Homosapiens

<400>  5345
ggaggattcc agaaggaaat tgcttcagct gcaagaaatg gggaacagag agagcgtcat     60

taaaatcaat ttggagaggg cagtaggtca ggtaggcatg ttccagagcc cccctcattg    120

gcccacgctc tccaatgatt gcacccaagc agccagtggg ggtgagagag gaggacgccc    180

aaggtagaaa gacagacgtg cgttaattct cccatttatc tcatgagcag aggctgtctg    240

cagctcccca cccccatgga catcgcttaa caggtttctg ctgctgggag gcctcccact    300

cgaatagttt acgatgaccc gagacccgga ccaggcagcc aatcccggct cgatgcctgc    360

ccccagttaa ccgagctcct tgcccccagt ggtgtttcta gcattttctc cttaatgttt    420

ttagtcctga catttaccac aatctttctt ccccttgggc cccagcagac attacagaca    480

gtgtctataa ggaaatgcca cttttcttaa taaggtaaaa ccctggagtg tccaaagtgc    540

gtgctggatg gagaagctcc cggctgtggg tgagccactc cgacctggtc tggaggtgct    600

gtttctttga tgctgtggcc tgaaatcgcc ggtggccctt cctggcaaat gtgacacagt    660

catgggggcc ggaatgtgca gacgaaagtt taccaaaagc taagggaaag caaacaggaa    720

accaagatgg gagggcatat gaccctgagg aatgtggtcc cccaggggca gcccacccta    780

gattcctcca caggggtccc tctcctggaa accatgactc caggggatcc acagaatggt    840

ttgcacacac acgtgtgtgt gcgtgtgtgt gtgtgtatta ctgggaagga gggcccccca    900

tgtctcccac tgggttctca ggagggtctg tgaactacca agaaaggtta aaagccagga    960

tctctcaaac cacccagctc agctcccaaa gcccttccat tttctaccat ccaagcctta   1020

ccaggcagtg tgaccaggcc tttgtccctg taccctaaaa ttcaaatatt caccactgta   1080

accgccagca ccatttctcc tgtgggggcg ccagcccctt atcaagggca gagaacctgc   1140

ctgtctgggc ctcttcctgt gcacattggc tacccccaat cttcccccta acacatacct   1200

gatttgaggg tctgacccgt gctccttgcc caagggccaa ggttcttgtt atagctctgg   1260

gcagaggtca tccaggagga gccctggagg tcctgagact gctccaggtc tagacttgag   1320

agaaaggaca agccctctct ctgcctccca gtgccttccc tctcctgtat ctccaaggcc   1380

ctgctccctg tccaatagtc tgcccttccc cagccaagtg accccaggcc cgaggccatg   1440

tctaagatga cctctccctc ccaatggccc tgggcagcca ttcctgtggg gagcccctga   1500

tggcaatggg ggaccatcat tcatagggct tcctctacac agtcaattct ttgggtgagc   1560

tgggaccctc cacttggcca tgaaaccaga ggatggcttt gagaacctca tgtcacctgg   1620

tcttctcctg gcagggtcac tgcagagatg tccgtaagac gtttcccatt agaactcccc   1680

tgtgcagtaa atacctgtgt cttgggcccc aggttgaggc agtagccctt ttggtccctt   1740

caaggctctg ctttggagta tttaataacc acgttttgcc agtgaactgg agactcacgc   1800

caggggctgc catgttggta aattctcaga gaaagtcggg ctccttttta cctctaacta   1860

ctaatggaat caggacacct tggacttgtc attctgtaag tccggactta atgtaactgc   1920

tatttcatca gccttaacct gaaaacacta gcacccagga ggggctcagt gaaagccact   1980

agaagtagag gcccttggct taaggtgatg tttctgtgta caggcatcca gcaaaggtta   2040

gttgggtgtc tgagtgtctc ctctacacca ggcaccgtag taggctccag ggataccgag   2100

atgaacagag tggacatagt cttcaggact cttatgggct caggcatgaa atggagaaag   2160

ggagaacact ctcctctccc cgggcttcct tgctgactac acaatttact tggactgaca   2220

gcctcaatat ttatttcaca gtctggtgcc aacttagcaa ttacggaaga gcgctcccgg   2280

ccccagactt cccattggat aattggcagc aagaggctct tctgagggtt tgagacatgt   2340

gtgtgcactg accacaggca tcgttcgggt taggcaggcg tgcctaaaaa gtaattaaag   2400

cctgctgttc tcttttcttc tgtgggtccc gccactcccc gtgagcggtg aagattctga   2460

taacgcggaa tggtcattca ggcgtgcaaa ccctgctaag tggtgtttcc cgcaccctgc   2520

catggaaacg ctgcccccac ttgccggccc ctgctgaccc cctgacactg ttgccccctc   2580

tctgctgcag ctggagcact tcagaagtca agtcatcaag gccacctatg gacgggcgaa   2640

gccgttccgg gacaagcccg tcaccgacca acagttaata gagaaaatta cccaggtcac   2700

tgaggacaac atcaattttc agcagaaaaa gtggaccctc cagaaagaga cccagctgag   2760

caactccaag caggaggaga ccaccgagaa catcgagaag ctgaggacgt cgctggacag   2820

ctgccaggtg gcccctcctt acgctttcca caaatggtct ctttgtctaa tttttgtgcg   2880

gcttatttgg gaaattgccc agcttttttg gagcaagttg ggcagaaatg cttggctttt   2940

ctatccactt tttcctcttg ttggagaaac ttgttggaga agaaaaaaca aagggcctaa   3000

aaaaatgcct cccgggagaa cttggcgtgt ccaaaaaaga tgcctgagca tcttcaatta   3060

ctgactttga gcggcccgca tccccagcca aaaagaaatt gttttcatag cccctatgtt   3120

atttccagag aaaccaaaga aacattcctg ctttttattt gcattttctt gttttggccc   3180

agccacaaaa ggcggtttcc acaccgttgc ttttgactct ggaggagcag ggacgggagg   3240

acttggccac agccctgcgg cccccaccct gggacatggc ttatcagagc aggcggtggc   3300

ttctgctttc tctggaaatc agcagctcct gtttggggag tttgtgcaaa tgctggcttg   3360

tcagcactct ttcaaatcag gaaaccacgc tttccgacca gcttgtgtgt tgatcttggc   3420

aggaattctg acgaatggaa aaaagaagta gccacatttg cttctcattg cagccaaact   3480

gttgatggta ctttggctct ggggtttcat agacctaaaa gggggttcgc tttgaccatc   3540

aaaagtccaa attagagtat taaaaaaaaa cctgtcaaaa cataaaaatt ttaaaaaaga   3600

aaaaaactga gtcctcccaa ggcggccaat acgtggcgct gcctgcttcg tggcagagtc   3660

aagaacgctg ttcctcgaag gtcacgtcag gggctatttc tggccacagg gcctgggctc   3720

ctcatgatct cacctctttg caggcttgca tgaaaatatc ctgttgcagc catgacctga   3780

agaaggaggt cgaccttctt cagcacctcc aggtgagccc acctgtctcg gggctccaga   3840

aggtggtgct ggacgtcctg aggcacgcgc tgtcctggct ggaggaggtg gagcagctcc   3900

tccgggacct cgggatcctg ccctccagcc ccaacaaagg ttactgggac tttttttctc   3960

acatggttgc atgactctaa aatgtcgcgt tgaatctcag catgatggga catctgttga   4020

ggaagtcttc ctgggtatct ggccaagtct attcccttct ccagaacccc ctgcttctct   4080

gcttgaggcg taattttcca ttaaaaaaaa aaacacacac atacaagtga gacacgataa   4140

ctgaagaaaa atgaaacaaa acagaggcaa aaggaaaatt aaatcgaaat tatgcaaagt   4200

ctaattacgc tgtttaacct ccaaggcatt ttcccatgga aataaccgcg tgattccagg   4260

caagtgactt accctgtcta tgcctcagtt tccctatctg taaaatgagg ctaataggga   4320

gtacccaccc tttagggctg ttgtgatcat taaaatgcat gaatatatgg aaagtacttg   4380

gaatagtacc tggcacacaa taggc                                         4405


<210>  5346
<211>  111
<212>  PRT
<213>  Homosapiens

<400>  5346

Met Leu Phe Pro Glu Lys Pro Lys Lys His Ser Cys Phe Leu Phe Ala 
1               5                   10                  15      


Phe Ser Cys Phe Gly Pro Ala Thr Lys Gly Gly Phe His Thr Val Ala 
            20                  25                  30          


Phe Asp Ser Gly Gly Ala Gly Thr Gly Gly Leu Gly His Ser Pro Ala 
        35                  40                  45              


Ala Pro Thr Leu Gly His Gly Leu Ser Glu Gln Ala Val Ala Ser Ala 
    50                  55                  60                  


Phe Ser Gly Asn Gln Gln Leu Leu Phe Gly Glu Phe Val Gln Met Leu 
65                  70                  75                  80  


Ala Cys Gln His Ser Phe Lys Ser Gly Asn His Ala Phe Arg Pro Ala 
                85                  90                  95      


Cys Val Leu Ile Leu Ala Gly Ile Leu Thr Asn Gly Lys Lys Lys 
            100                 105                 110     


<210>  5347
<211>  3105
<212>  DNA
<213>  Homosapiens

<400>  5347
aaaataaggc atttgggatg ccgatgttaa aaggagaagg taatcagaga agaaaaaagg     60

aagtcggtgg agagttctgc gaagattttg aagatttcta gcagagaagc agggggttct    120

ggagaaggga atagacttgg ccagataccc aggaagactt cctcaacaga tgtcccatca    180

tgctgagatt caacgcgaca ttttagagtc atgcaaccat gtgagaaaaa aagtcccagt    240

aacctttgtt ggggctggag ggcaggatcc cgaggtcccg gaggagctgc tccacctcct    300

ccagccagga cagcgcgtgc ctcaggacgt ccagcaccac cttctggagc cccgagacag    360

gtgggctcac ctggaggtgc tgaagaaggt cgacctcctt cttcaggtca tggctgcaac    420

aggatatttt catgcaagcc tgcaaagagg tgagatcatg aggagcccag gccctgtggc    480

cagaaatagc ccctgacgtg accttcgagg aacagcgttc ttgactctgc cacgaagcag    540

gcagcgccac gtattggccg ccttgggagg actcagtttt tttctttttt aaaattttta    600

tgttttgaca ggtttttttt taatactcta atttggactt ttgatggtca aagcgaaccc    660

ccttttaggt ctatgaaacc ccagagccaa agtaccatca acagtttggc tgcaatgaga    720

agcaaatgtg gctacttctt ttttccattc gtcagaattc ctgccaagat caacacacaa    780

gctggtcgga aagcgtggtt tcctgatttg aaagagtgct gacaagccag catttgcaca    840

aactccccaa acaggagctg ctgatttcca gagaaagcag aagccaccgc ctgctctgat    900

aagccatgtc ccagggtggg ggccgcaggg ctgtggccaa gtcctcccgt ccctgctcct    960

ccagagtcaa aagcaacggt gtggaaaccg ccttttgtgg ctgggccaaa acaagaaaat   1020

gcaaataaaa agcaggaatg tttctttggt ttctctggaa ataacatagg ggctatgaaa   1080

acaatttctt tttggctggg gatgcgggcc gctcaaagtc agtaattgaa gatgctcagg   1140

catctttttt ggacacgcca agttctcccg ggaggcattt ttttaggccc tttgtttttt   1200

cttctccaac aagtttctcc aacaagagga aaaagtggat agaaaagcca agcatttctg   1260

cccaacttgc tccaaaaaag ctgggcaatt tcccaaataa gccgcacaaa aattagacaa   1320

agagaccatt tgtggaaagc gtaaggaggg gccacctggc agctgtccag cgacgtcctc   1380

agcttctcga tgttctcggt ggtctcctcc tgcttggagt tgctcagctg ggtctctttc   1440

tggagggtcc actttttctg ctgaaaattg atgttgtcct cagtgacctg ggtaattttc   1500

tctattaact ggtgagaaaa agaaaaagga aaaaaaaaaa aaagatgtaa catacagggg   1560

tggggggccc tgagggaagg ggaatgggag aggggagaga tgcaacttaa gtccctgtct   1620

aagcacggga ggacagaggt cctgatatgt cttggtgatg gctgtcaagg gggacgttgg   1680

tcctgtcacc agggaatgag tcccagaatc agagattctc ttttcttttt tcttttcttt   1740

tttttttttt tgcgacggag tttcactctt gttgcccagg ctggagtgca atggtttgat   1800

ctcggctcac cgcaacctcc gcctcctggg ttcaagcgat tctcctgcct cagcctctga   1860

agtagctgag attacaggca cgcgccacca tgcccggcta attttgtatt tttaatagag   1920

atggggtttt accatgttgg tcaggctggt ttcgaactcc cgacctgagg tgatccaccc   1980

gcctcggcct ctcaaagtgc tggcattaca ggcatgagcc accactcctt gccgatcaga   2040

gattattttt atgatccaaa ggcctgtctt gtggccctga gtttgttcca gattcttctg   2100

tgttgtatag ggattcagaa cactgagcct gatattatgg gctcataagc agcaggtcag   2160

gttctcccac acccactgag agcagcccac ggcacatttt cccatctgtg ctttgacaca   2220

gggggctaga aagtgtagtg gaagaacagc aaggcaatca ttacagccag acatccaccc   2280

tcactgccac tgtcaacttt tctcctctga aggaacgcgc cagaacgcac tggctgtggg   2340

gaggcggctc cctttctccc agtgctaatg gaggcgaaac atgcatgtct ggagaccaga   2400

agtaagcccg aatggtttaa tttgattttc acagacacat ttcaagggag ttttaactgg   2460

cttttacttt aaaagccagg aaatcccata aaatcaaaac aaatctttat ggtgtagcaa   2520

cagtgtgaaa aatatgccac caacaaaaac agaaacatat gctcccaggg tctggaatcc   2580

agatccacga agaagaagaa gaggaaagtg aaggagccac gtggcaggga cggcagacta   2640

acctgttggt cggtgacggg cttgtcccgg aacggcttcg cccgtccata ggtggccttg   2700

atgacttgac ttctgaagtg ctccagctgc agcagagagg gggcaacagt gtcagggggt   2760

cagcaggggc cggcaagtgg gggcagcgtt tccatggcag ggtgcgggaa acaccactta   2820

gcagggtttg cacgcctgaa tgaccattcc gcgttatcag aatcttcacc gctcacgggg   2880

agtggcggga cccacagaag aaaagagaac agcaggcttt aattactttt taggcacgcc   2940

tgcctaaccc gaacgatgcc tgtggtcagt gcacacacat gtctcaaacc ctcagaagag   3000

cctcttgctg ccaattatcc aatgggaagt ctggggccgg gagcgctctt ccgtaattgc   3060

taagttggca ccagactgtg aaataaatat tgaggctgtc agtcc                   3105


<210>  5348
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  5348

Met Ser His His Ala Glu Ile Gln Arg Asp Ile Leu Glu Ser Cys Asn 
1               5                   10                  15      


His Val Arg Lys Lys Val Pro Val Thr Phe Val Gly Ala Gly Gly Gln 
            20                  25                  30          


Asp Pro Glu Val Pro Glu Glu Leu Leu His Leu Leu Gln Pro Gly Gln 
        35                  40                  45              


Arg Val Pro Gln Asp Val Gln His His Leu Leu Glu Pro Arg Asp Arg 
    50                  55                  60                  


Trp Ala His Leu Glu Val Leu Lys Lys Val Asp Leu Leu Leu Gln Val 
65                  70                  75                  80  


Met Ala Ala Thr Gly Tyr Phe His Ala Ser Leu Gln Arg Gly Glu Ile 
                85                  90                  95      


Met Arg Ser Pro Gly Pro Val Ala Arg Asn Ser Pro 
            100                 105             


<210>  5349
<211>  1623
<212>  DNA
<213>  Homosapiens

<400>  5349
tgaccacagg catcgttcgg gttaggcagg cgtgcctaaa aagtaattaa agcctgctgt     60

tctcttttct tctgtgggtc ccgccactcc ccgtgagcgg tgaagattct gataacgcgg    120

aatggtcatt caggcgtgca aaccctgcta agtggtgttt cccgcaccct gccatggaaa    180

cgctgccccc acttgccggc ccctgctgac cccctgacac tgttgccccc tctctgctgc    240

agctggagca cttcagaagt caagtcatca aggccaccta tggacgggcg aagccgttcc    300

gggacaagcc cgtcaccgac caacagttaa tagagaaaat tacccaggtc actgaggaca    360

acatcaattt tcagcagaaa aagtggaccc tccagaaaga gacccagctg agcaactcca    420

agcaggagga gaccaccgag aacatcgaga agctgaggac gtcgctggac agctgccagg    480

cttgcatgaa aatatcctgt tgcagccatg acctgaagaa ggaggtcgac cttcttcagc    540

acctccaggt gagcccacct gtctcggggc tccagaaggt ggtgctggac gtcctgaggc    600

acgcgctgtc ctggctggag gaggtggagc agctcctccg ggacctcggg atcctgccct    660

ccagccccaa caaaggttac tgggactttt tttctcacat ggttgcatga ctctaaaatg    720

tcgcgttgaa tctcagcatg atgggacatc tgttgaggaa gtcttcctgg gtatctggcc    780

aagtctattc ccttctccag aaccccctgc ttctctgctt gaggcgtaat tttccattaa    840

aaaaaaaaac acacacatac aagtgagaca cgataactga agaaaaatga aacaaaacag    900

aggcaaaagg aaaattaaat cgaaattatg caaagtctaa ttacgctgtt taacctccaa    960

ggcattttcc catggaaata accgcgtgat tccaggcaag tgacttaccc tgtctatgcc   1020

tcagtttccc tatctgtaaa atgaggctaa tagggagtac ccacccttta gggctgttgt   1080

gatcattaaa atgcatgaat atatggaaag tacttggaat agtacctggc acacaatagg   1140

cattactgaa tgtttattga cttttaattt gacaaaaaaa tagtgtcacg ttaccctcga   1200

ttttctttgg tttattccta atggtacgtc atccatgtca gtagacacag acctacatca   1260

tcgctgttac cgacggcagt tactgattcc attgtgtagg atgtgccatt gttttagaca   1320

atcccctatc atgggcactt aggtgatttc cagtttttca cactcataaa tcatgctggg   1380

atgaacattg ttgcacacat acctgctcat attatcttta ttctcctaga ggtggagagg   1440

tatgaatcac tttctttcaa caaatagtga ttgcatgcat gcttaccaga ggccacatgt   1500

tgtgcagggc agagacgtaa cggggtcagg aacaggtaga atcaggtcat gggtatatgg   1560

ttcactgtaa aattcttcca atatgtccat acatttgaaa ttttttataa taaaatactg   1620

ggg                                                                 1623


<210>  5350
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  5350

Met Lys Ile Ser Cys Cys Ser His Asp Leu Lys Lys Glu Val Asp Leu 
1               5                   10                  15      


Leu Gln His Leu Gln Val Ser Pro Pro Val Ser Gly Leu Gln Lys Val 
            20                  25                  30          


Val Leu Asp Val Leu Arg His Ala Leu Ser Trp Leu Glu Glu Val Glu 
        35                  40                  45              


Gln Leu Leu Arg Asp Leu Gly Ile Leu Pro Ser Ser Pro Asn Lys Gly 
    50                  55                  60                  


Tyr Trp Asp Phe Phe Ser His Met Val Ala 
65                  70                  


<210>  5351
<211>  486
<212>  DNA
<213>  Homosapiens

<400>  5351
ttctggagcc ccgagacagg tgggctcacc tggaggtgct gaagaaggtc gacctccttc     60

ttcaggtcat ggctgcaaca ggatattttc atgcaagcct gcaaagaggt gagatcatga    120

ggagcccagg ccctgtggcc agaaatagcc cctgacgtga ccttcgagga acagcgtttt    180

cttttttcca ttcgtcagaa ttcctgccaa gatcaacaca caagctggtc ggaaagcgtg    240

gtttcctgat ttgaaagagt gctgacaagc cagcatttgc acaaactccc caaacaggag    300

ctgctgattt ccagagaaag cagaagccac cgcctgctct gataagccat gtcccagggt    360

gggggccgca gggctgtggc caagtcctcc cgtccctgct cctccagagt caaaagcaac    420

ggtgtggaaa ccgccttttg tggctgggcc aaaacaagaa aatgcaaata aaaagcagga    480

atgttt                                                               486


<210>  5352
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5352

Met Ser Gln Gly Gly Gly Arg Arg Ala Val Ala Lys Ser Ser Arg Pro 
1               5                   10                  15      


Cys Ser Ser Arg Val Lys Ser Asn Gly Val Glu Thr Ala Phe Cys Gly 
            20                  25                  30          


Trp Ala Lys Thr Arg Lys Cys Lys 
        35                  40  


<210>  5353
<211>  725
<212>  DNA
<213>  Homosapiens

<400>  5353
aaaagttgcc cagagtcaca cagctggtac attagggtta agactcaaac tgaggtcttt     60

gtgaccctaa cacctgtgtc ttccctatga ccccctgccc cttcaccccc accccctgca    120

cacatacaca cttcctctga caatgcagca atgtaccagg cacatgccca gtccctagag    180

aatgggtgct gtcatcggct caggcagtga cagagctaag agttgtcttt ccctaagcta    240

aaccgcatct gattcctacc ctgagccata accacagaaa gccccatttg tatcacagtg    300

atgttccaag ctgggactct gggtaccact gccaaggctt gaatttcagc tgtgcaccta    360

ctagctgtgt gggcagttac gtgacgtggc tgcgcctcca tttacttgct cgtgaaatgg    420

ccatccagtc tcctagcggc atatgaggac tgagtgatgg gatacatgca tggcagtgct    480

ggtcacagtt agctcgtaat cggtgggggc tgctgtcatc gtcagcctca aatactggtt    540

tctcagggtt cctctgataa gggaaggaaa ggatttttta catttttctc tgcaagctcc    600

gtcgtttgtg tctatttctg caagactttg ttacaaataa aagactcttc ttgcatgcat    660

ggcaaatcac tcaactatcc aagatacact gtgtctttaa ctgaaaagaa agcaagttgc    720

aatac                                                                725


<210>  5354
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  5354

Ser Val Gly Ala Ala Val Ile Val Ser Leu Lys Tyr Trp Phe Leu Arg 
1               5                   10                  15      


Val Pro Leu Ile Arg Glu Gly Lys Asp Phe Leu His Phe Ser Leu Gln 
            20                  25                  30          


Ala Pro Ser Phe Val Ser Ile Ser Ala Arg Leu Cys Tyr Lys 
        35                  40                  45      


<210>  5355
<211>  1378
<212>  DNA
<213>  Homosapiens

<400>  5355
gagacagaca tgacagccct cctcaaatat ttaaagggct gtctcataaa agagaaataa     60

aacatactca atgagctcca ggtgacagaa ctgagctcag agaccagaaa tcacaaggag    120

acagatctcc gctgaatata aagacgagtt ctataataat tggaaccttc cagagaaggc    180

atggactttg tgctttaaaa gaatcgacag aataattaga gaatagactt taccctgtcc    240

ttgaaggtgg gggataaggg ggctgggtaa atatgtattc ctgaatgtct gttattttgc    300

tacttgtttt tttgtctagg aattagaatt aaaagagcaa aaagaggacg ttttaaataa    360

taaattaagt gacgcactgg ccatggttga agagactcag aaaacaaagg caactgaaag    420

tctaaaagca gagagcctcg ccttgaaatt aaatgaaaca ttagccgaac tggaaactac    480

caagacaaaa atgatcatgg tggaagagcg gctaatcctg cagcagaaga tggtaaaggc    540

cctccaggat gagcaggaat cacagagaca cgggtttgaa gaagagatca tggaatataa    600

ggagcaaatc aaacagcacg cccagacaat tgtgagcctc gaagagaaac tccagaaagt    660

cactcagcac cataaaaaaa tagaaggcga gattgcaaca ttgaaggaca atgacccagc    720

cccaaaggag gaaaggccgc aagaccctct ggtggctccc atgacagaga gcagtgccaa    780

agacatggcg tacgaacatc tgattgagtc tacaaagaag tctatcctca aagaactgac    840

agttttcaga gaaacaaacg tatgaatggg aaagatccag aaagcagcac gtaaagaagg    900

aggcgccgat gggatgcagt ggagggattc agaagctccc ccaagaggag aaccacctgc    960

ctgacccttg caccaaatcc tagtgaccga agtctaatgt cacagggttt ttaccccaaa   1020

aagacaagga tactcagcct ccgcattgtg aaaagttcct gactcctcct cctgtttaaa   1080

atctagaaac ggtggtgccc atgacttgga gaagactcag caccacccag ctctgctctg   1140

gtccacttcc ttggcgtgtg aacatgcttg aattctaagg ttttatcctc aagttggaag   1200

atttgtggtt gcagccaaga acacactcac gtggacacac acgcatgcat gcacacacag   1260

aatatactat atctatgtag ttattttcat tctgatgatc accagtcttt ttgtttgttt   1320

gtttgacatg caacctgcca gtgttttact ttaattcata ataaacacag taccttct     1378


<210>  5356
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  5356

Met Val Glu Glu Thr Gln Lys Thr Lys Ala Thr Glu Ser Leu Lys Ala 
1               5                   10                  15      


Glu Ser Leu Ala Leu Lys Leu Asn Glu Thr Leu Ala Glu Leu Glu Thr 
            20                  25                  30          


Thr Lys Thr Lys Met Ile Met Val Glu Glu Arg Leu Ile Leu Gln Gln 
        35                  40                  45              


Lys Met Val Lys Ala Leu Gln Asp Glu Gln Glu Ser Gln Arg His Gly 
    50                  55                  60                  


Phe Glu Glu Glu Ile Met Glu Tyr Lys Glu Gln Ile Lys Gln His Ala 
65                  70                  75                  80  


Gln Thr Ile Val Ser Leu Glu Glu Lys Leu Gln Lys Val Thr Gln His 
                85                  90                  95      


His Lys Lys Ile Glu Gly Glu Ile Ala Thr Leu Lys Asp Asn Asp Pro 
            100                 105                 110         


Ala Pro Lys Glu Glu Arg Pro Gln Asp Pro Leu Val Ala Pro Met Thr 
        115                 120                 125             


Glu Ser Ser Ala Lys Asp Met Ala Tyr Glu His Leu Ile Glu Ser Thr 
    130                 135                 140                 


Lys Lys Ser Ile Leu Lys Glu Leu Thr Val Phe Arg Glu Thr Asn Val 
145                 150                 155                 160 


<210>  5357
<211>  2308
<212>  DNA
<213>  Homosapiens

<400>  5357
agatgactta ttggctgctc agaaggaaat tctgtctcag caggaagtca tcatgaagtt     60

aaggaaagac cttaccgaag cccacagcag aatgtcggat ttgagagggg agctaaacga    120

gaagcagaag atggaactgg agcagaacgt ggtgctggtc cagcagcaga gcaaggagct    180

gagtgtgctc aaggagaaga tggcccagat gagcagcctg gtagaaaaga aagatcggga    240

gctgaaggcc cttgaggagg cactcagggc ttcccaagag aaacacagac tccagctgaa    300

cacagagaag gaacagaagc cccggaagaa gacccagacg tgtgacacct ctgtgcagat    360

agaacccgtc cacactgagg ccttctccag cagccaagag cagcaatcct tcagcgatct    420

aggggtcagg tgcaaagggt cccggcacga ggaggtcatt cagcgtcaga aaaaggcctt    480

atctgaactt cgagcgcgaa ttaaagaact cgagaaggcg cgctcaccag atcataaaga    540

ccaccagaat gaatcatttc tagatttaaa gaacctcaga atggaaaaca atgtccagaa    600

aatactactg gatgcaaaac cggatttgcc aactctctca agaatagaga tcctagcgcc    660

tcagaatggc ctttgcaacg caaggttcgg ctcagccatg gagaagtcag ggaagatgga    720

tgtggctgag gctttagagc tcagtgaaaa gctgtacctg gatatgagca aaaccctcgg    780

aagtctcatg aacatcaaga atatgtcagg ccacgtgtcc atgaaatacc tctcccgcca    840

ggagagggag aaggtcaacc agcttcgaca aagggacctc gacctggtgt ttgataagat    900

cacccaactc aagaaccagc tggggaggaa agaggagctg ttgagaggat atgaaaagga    960

cgttgaacag ctcaggcgga gcaaagtgtc cattgagatg taccagtcgc aggtggcaaa   1020

gctggaggat gatatctaca aagaggccga agagaaggcc ctgctgaagg aggccctgga   1080

gcgcatggag caccagctgt gccaggagaa gaggatcaac agggccatcc ggcagcagaa   1140

gatgaggaaa ctgcgcctca gagagttaag aggcgcccaa gtgcacacag cggctggtaa   1200

ggacagctgg gacctgaccc cagatccctc tgaccctggt tctcctgctg tctgcagggt   1260

tggccgaaag tgtagaggag cacgaactga gaaacgcaaa agaatcgaca ccttgcaact   1320

gtgccttcaa agagaaagac aggcaggccc tgccccacct gcctgcagtt tgaacggatg   1380

acctaagaga caagcacgcg tccagccccg tctgtccatt aagagacgag tatttgtaga   1440

gatggtgaag aacaggatgc agaactcaaa ttcccaggtt ggaaccagaa aagcctccct   1500

aaagatggac caagaaagag agatgctgag gaaagagacc tccagcaagt ccagccagag   1560

ccttttgcat tctaagccca gtggaaagta ctagagaaac ctcgtcccac caggcctcat   1620

gtgatcctct gtgagttcat gtgactcttc tgtgtcatct gtgtcaaaat actgagttgc   1680

ttttgtaagt ctttaaagat tgttacccta gtgtttcatt tcctagacca gtattttgaa   1740

caatattata ttttggagac tgtggggaga agggttcttc tttaaaaata cctatgaatg   1800

tacacgaact caggtatatg aagaatagaa gtgtgtaacc cagatgtcca ggcctggtag   1860

atataattat gtggtccacg ttgggtcatg atgttcccaa atatcaaacc tcctaagact   1920

tccaacagac tcacacttga gaaaacctaa gacttgtact ggagcctcag ggcagaattg   1980

taaccttgga gctctcaggg ccttgggata gtgaattcaa gtctccgtta tggcctggca   2040

ggatggctca tgcctgtaat ctcagcactt tgggaggccg aggcaggcgg attataagat   2100

caggagtttg agaccagcct ggcaaacata gtgaatacct gtctctacta aaaatacaaa   2160

aattagccag gtgtggtggc acatgcctgt agtcccagct acacaggagg ctgaggtggg   2220

agaatcactt gaacctagga ggcagaggtt gcagtgagcc aagaccacgc cattgcacgc   2280

cagcctaaca gagtgagact ctgtcttt                                      2308


<210>  5358
<211>  442
<212>  PRT
<213>  Homosapiens

<400>  5358

Met Lys Leu Arg Lys Asp Leu Thr Glu Ala His Ser Arg Met Ser Asp 
1               5                   10                  15      


Leu Arg Gly Glu Leu Asn Glu Lys Gln Lys Met Glu Leu Glu Gln Asn 
            20                  25                  30          


Val Val Leu Val Gln Gln Gln Ser Lys Glu Leu Ser Val Leu Lys Glu 
        35                  40                  45              


Lys Met Ala Gln Met Ser Ser Leu Val Glu Lys Lys Asp Arg Glu Leu 
    50                  55                  60                  


Lys Ala Leu Glu Glu Ala Leu Arg Ala Ser Gln Glu Lys His Arg Leu 
65                  70                  75                  80  


Gln Leu Asn Thr Glu Lys Glu Gln Lys Pro Arg Lys Lys Thr Gln Thr 
                85                  90                  95      


Cys Asp Thr Ser Val Gln Ile Glu Pro Val His Thr Glu Ala Phe Ser 
            100                 105                 110         


Ser Ser Gln Glu Gln Gln Ser Phe Ser Asp Leu Gly Val Arg Cys Lys 
        115                 120                 125             


Gly Ser Arg His Glu Glu Val Ile Gln Arg Gln Lys Lys Ala Leu Ser 
    130                 135                 140                 


Glu Leu Arg Ala Arg Ile Lys Glu Leu Glu Lys Ala Arg Ser Pro Asp 
145                 150                 155                 160 


His Lys Asp His Gln Asn Glu Ser Phe Leu Asp Leu Lys Asn Leu Arg 
                165                 170                 175     


Met Glu Asn Asn Val Gln Lys Ile Leu Leu Asp Ala Lys Pro Asp Leu 
            180                 185                 190         


Pro Thr Leu Ser Arg Ile Glu Ile Leu Ala Pro Gln Asn Gly Leu Cys 
        195                 200                 205             


Asn Ala Arg Phe Gly Ser Ala Met Glu Lys Ser Gly Lys Met Asp Val 
    210                 215                 220                 


Ala Glu Ala Leu Glu Leu Ser Glu Lys Leu Tyr Leu Asp Met Ser Lys 
225                 230                 235                 240 


Thr Leu Gly Ser Leu Met Asn Ile Lys Asn Met Ser Gly His Val Ser 
                245                 250                 255     


Met Lys Tyr Leu Ser Arg Gln Glu Arg Glu Lys Val Asn Gln Leu Arg 
            260                 265                 270         


Gln Arg Asp Leu Asp Leu Val Phe Asp Lys Ile Thr Gln Leu Lys Asn 
        275                 280                 285             


Gln Leu Gly Arg Lys Glu Glu Leu Leu Arg Gly Tyr Glu Lys Asp Val 
    290                 295                 300                 


Glu Gln Leu Arg Arg Ser Lys Val Ser Ile Glu Met Tyr Gln Ser Gln 
305                 310                 315                 320 


Val Ala Lys Leu Glu Asp Asp Ile Tyr Lys Glu Ala Glu Glu Lys Ala 
                325                 330                 335     


Leu Leu Lys Glu Ala Leu Glu Arg Met Glu His Gln Leu Cys Gln Glu 
            340                 345                 350         


Lys Arg Ile Asn Arg Ala Ile Arg Gln Gln Lys Met Arg Lys Leu Arg 
        355                 360                 365             


Leu Arg Glu Leu Arg Gly Ala Gln Val His Thr Ala Ala Gly Lys Asp 
    370                 375                 380                 


Ser Trp Asp Leu Thr Pro Asp Pro Ser Asp Pro Gly Ser Pro Ala Val 
385                 390                 395                 400 


Cys Arg Val Gly Arg Lys Cys Arg Gly Ala Arg Thr Glu Lys Arg Lys 
                405                 410                 415     


Arg Ile Asp Thr Leu Gln Leu Cys Leu Gln Arg Glu Arg Gln Ala Gly 
            420                 425                 430         


Pro Ala Pro Pro Ala Cys Ser Leu Asn Gly 
        435                 440         


<210>  5359
<211>  1240
<212>  DNA
<213>  Homosapiens

<400>  5359
gcctcagaat ggcctttgca acgcaaggtt cggctcagcc atggagaagt cagggaagat     60

ggatgtggct gaggctttag agctcagtga aaagctgtac ctggatatga gcaaaaccct    120

cggaagtctc atgaacatca agaatatgtc aggccacgtg tccatgaaat acctctcccg    180

ccaggagagg gagaaggtca accagcttcg acaaagggac ctcgacctgg tgtttgataa    240

gatcacccaa ctcaagaacc agctggggag gaaagaggag ctgttgagag gatatgaaaa    300

ggacgttgaa cagctcaggc ggagcaaagt gtccattgag atgtaccagt cgcaggtggc    360

aaagctggag gatgatatct acaaagaggc cgaagagaag gccctgctga aggaggccct    420

ggagcgcatg gagcaccagc tgtgccagga gaagaggatc aacagggcca tccggcagca    480

gaaggaaagt gtagaggagc acgaactgag aaacgcaaaa gaatcgacac cttgcaactg    540

tgccttcaaa gagaaagaca ggcaggccct gccccacctg cctgcagttt gaacggatga    600

cctaagagac aagcacgcgt ccagccccgt ctgtccatta agagtcttgc tctattgccc    660

aggctagagt gcagtggtgc aatttcggct cactgcaacc tccacctccc aggttcaagc    720

gattctcctg cctcagcctc ccgagtagct gggactacag gttggaacca gaaaagcctc    780

cctaaagatg gaccaagaaa gagagatgct gaggaaagag acctccagca agtccagcca    840

gagccttttg cattctaagc ccagtggaaa gtactagaga aacctcgtcc caccaggcct    900

catgtgatcc tctctaggac gggccatgtt ggaccaatct ggctaatgac atataaggaa    960

aagctcctgt ggagggcttc ccttccagct tctctaggtg aaagcattca cccttggtac   1020

ctttgtcttg tctcctttct cactcctgga gctcagacca gaagctggag cagccacctt   1080

ggggatcagc agacaccagc agcaggccaa aggatagtgg agtggaggga caagaaggcc   1140

tgggtgagcc ttctctgaga atcactgagc tctgaaccat gaatgaactg cctacctctg   1200

tacttcctgt tgtataggac aaagaaatcc ctatctattt                         1240


<210>  5360
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  5360

Met Glu Lys Ser Gly Lys Met Asp Val Ala Glu Ala Leu Glu Leu Ser 
1               5                   10                  15      


Glu Lys Leu Tyr Leu Asp Met Ser Lys Thr Leu Gly Ser Leu Met Asn 
            20                  25                  30          


Ile Lys Asn Met Ser Gly His Val Ser Met Lys Tyr Leu Ser Arg Gln 
        35                  40                  45              


Glu Arg Glu Lys Val Asn Gln Leu Arg Gln Arg Asp Leu Asp Leu Val 
    50                  55                  60                  


Phe Asp Lys Ile Thr Gln Leu Lys Asn Gln Leu Gly Arg Lys Glu Glu 
65                  70                  75                  80  


Leu Leu Arg Gly Tyr Glu Lys Asp Val Glu Gln Leu Arg Arg Ser Lys 
                85                  90                  95      


Val Ser Ile Glu Met Tyr Gln Ser Gln Val Ala Lys Leu Glu Asp Asp 
            100                 105                 110         


Ile Tyr Lys Glu Ala Glu Glu Lys Ala Leu Leu Lys Glu Ala Leu Glu 
        115                 120                 125             


Arg Met Glu His Gln Leu Cys Gln Glu Lys Arg Ile Asn Arg Ala Ile 
    130                 135                 140                 


Arg Gln Gln Lys Glu Ser Val Glu Glu His Glu Leu Arg Asn Ala Lys 
145                 150                 155                 160 


Glu Ser Thr Pro Cys Asn Cys Ala Phe Lys Glu Lys Asp Arg Gln Ala 
                165                 170                 175     


Leu Pro His Leu Pro Ala Val 
            180             


<210>  5361
<211>  695
<212>  DNA
<213>  Homosapiens

<400>  5361
tgtcaggcca cgtgtccatg aaatacctct cccgccagga gagggagaag gtcaaccagc     60

ttcgacaaag ggacctcgac ctggtgtttg ataagatcac ccaactcaag aaccagctgg    120

ggaggaaaga ggagctgttg agaggatatg aaaaggacgt tgaacagctc aggcggagca    180

aagtgtccat tgagatgtac cagtcgcagg tggcaaagct ggaggatgat atctacaaag    240

aggccgaaga gaaggccctg ctgaaggagg ccctggagcg catggagcac cagctgtgcc    300

aggagaagag gatcaacagg gccatccggc agcagaagta gatgggagct tccagcccct    360

gcctcgcaga cagatggtga ggatgaaaga atgcaggcat ccctcgctat ctgctgtcca    420

ctctcgctgt cgtcatacct caggagccaa gtgcttttgg atggttggaa ccagaaaagc    480

ctccctaaag atggaccaag aaagagagat gctgaggaaa gagacctcca gcaagtccag    540

ccagagcctt ttgcattcta agcccagtgg aaagtactag agaaacctcg tcccaccagg    600

cctcatgtga tcctctgtga gttcatgtga ctcttctgtg tcatctgtgt caaaatactg    660

agttgctttt gtaagtcttt aaagattgtt accct                               695


<210>  5362
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  5362

Met Lys Tyr Leu Ser Arg Gln Glu Arg Glu Lys Val Asn Gln Leu Arg 
1               5                   10                  15      


Gln Arg Asp Leu Asp Leu Val Phe Asp Lys Ile Thr Gln Leu Lys Asn 
            20                  25                  30          


Gln Leu Gly Arg Lys Glu Glu Leu Leu Arg Gly Tyr Glu Lys Asp Val 
        35                  40                  45              


Glu Gln Leu Arg Arg Ser Lys Val Ser Ile Glu Met Tyr Gln Ser Gln 
    50                  55                  60                  


Val Ala Lys Leu Glu Asp Asp Ile Tyr Lys Glu Ala Glu Glu Lys Ala 
65                  70                  75                  80  


Leu Leu Lys Glu Ala Leu Glu Arg Met Glu His Gln Leu Cys Gln Glu 
                85                  90                  95      


Lys Arg Ile Asn Arg Ala Ile Arg Gln Gln Lys 
            100                 105         


<210>  5363
<211>  367
<212>  DNA
<213>  Homosapiens

<400>  5363
cgtgacccat gcaggtggtc tcctggatga ggaaactgcg cctcagagag ttaagaggcg     60

cccaagtgca cacagcggct gagacgagta tttgtagaga tggtgaagaa caggatgcag    120

aactcaaatt cccaggttgg aaccagaaaa gcctccctaa agatggacca agaaagagag    180

atgctgagga aagagacctc cagcaagtcc agccagagcc ttttgcattc taagcccagt    240

ggaaagtact agagaaacct cgtcccacca ggcctcatgt gatcctctgt gagttcatgt    300

gactcttctg tgtcatctgt gtcaaaatac tgagttgctt ttgtaagtct ttaaagattg    360

ttaccct                                                              367


<210>  5364
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  5364

Met Gln Val Val Ser Trp Met Arg Lys Leu Arg Leu Arg Glu Leu Arg 
1               5                   10                  15      


Gly Ala Gln Val His Thr Ala Ala Glu Thr Ser Ile Cys Arg Asp Gly 
            20                  25                  30          


Glu Glu Gln Asp Ala Glu Leu Lys Phe Pro Gly Trp Asn Gln Lys Ser 
        35                  40                  45              


Leu Pro Lys Asp Gly Pro Arg Lys Arg Asp Ala Glu Glu Arg Asp Leu 
    50                  55                  60                  


Gln Gln Val Gln Pro Glu Pro Phe Ala Phe 
65                  70                  


<210>  5365
<211>  919
<212>  DNA
<213>  Homosapiens

<400>  5365
ccccagggtc agcaactgta aaccaaaccc cagggaaata gcaagcttca gattctgggt     60

gacgatgaca ttcaaacagg cccctaaagg gagttcaacc atcatgggcc ccaccatccc    120

tgagccattg ggataccgag gtgtgaacca ccgggcatct gcagcccctt ccacttgctc    180

tgggaggcgc tgcctcgagc taaaacagac gtgtcctccg agaagagcat tgttcctcac    240

aggccctggg ttgagcagcc tccacctctg ctggaatcta gaacagagac ccccaagaga    300

ctcagcaaga tggggcactg tggctcccaa aagctgtgcc cccttctcgt tgagaaaatg    360

gatttttctc aattttcaga tgctacctgt ttggaatgct gtccctggga aggcccagcg    420

ttccaaatgg ttagcatcta aaagtggaga aaaatccatt tttctttgat gcaaaaggca    480

aagaggaatc taagctagat tttgttctta ttctttctgt attgaagaga cgagtatttg    540

tagagatggt gaagaacagg atgcagaact caaattccca ggttggaacc agaaaagcct    600

ccctaaagat ggaccaagaa agagagatgc tgaggaaaga gacctccagc aagtccagcc    660

agagcctttt gcattctaag cccagtggaa agtactagag aaacctcgtc ccaccaggcc    720

tcatgtgatc ctctaccaga agctggagca gccaccttgg ggatcagcag acaccagcag    780

caggccaaag gatagtggag tggagggaca agaaggcctg ggtgagcctt ctctgagaat    840

cactgagctc tgaaccatga atgaactgcc tacctctgta cttcctgttg tataggacaa    900

agaaatccct atctattta                                                 919


<210>  5366
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  5366

Met Val Lys Asn Arg Met Gln Asn Ser Asn Ser Gln Val Gly Thr Arg 
1               5                   10                  15      


Lys Ala Ser Leu Lys Met Asp Gln Glu Arg Glu Met Leu Arg Lys Glu 
            20                  25                  30          


Thr Ser Ser Lys Ser Ser Gln Ser Leu Leu His Ser Lys Pro Ser Gly 
        35                  40                  45              


Lys Tyr 
    50  


<210>  5367
<211>  4500
<212>  DNA
<213>  Homosapiens

<400>  5367
gcaggggttc cgaggcggac ctggggagca gaaacccctg tttagggtga accgtggcgg     60

gcgccgatgg cctcttggaa gaggacagac tagcagctgc gagggagatg ggactgggtt    120

tcacccctga aagggcccct ggagacagcg gggaaactga cagggagatc atgatgtcgc    180

cattttgatg gggtccccag aggagagatg tcctccccaa cggctcctgg acaggactgg    240

ggaaagagtt cagataaggc tgctgaacgc cggagcctta caactgttaa actcaggcag    300

agctcgggaa atgctgcccg gatgggtgag tccttttaac acctcttggg ttgatttttc    360

tcacaggttt tcggggtttg cagagctctg agactgtgac cacagggtga gacctcaagc    420

tgcccagtac tgtggcccca tttcagaggc cttgggcctg ggccagagat ggacgctggg    480

gctgcctttt actccaagtt tttttcttca ttggtcattg gtcattgggc tccaagaaaa    540

gcactttttc aggaatcaaa gaagcagtga tggaacgaaa agcagagaaa gctgatgagc    600

cctgaatgga ggtgaaactt ccaggaaata tcacttgcct cttgattagg ggaaatcact    660

tttgaatgac cccgagtttt gtgccccaag catagattct ggcagaaaga aacagtctgg    720

actgatgaca cactacaaca tttggtcatg tggaaagaat gatcttcagg aaaaatcaca    780

cccttggcaa aggcttttta cagaggcaag ggcgagccgg ccaattctga caatattcca    840

gtggcaaggg agccaggctg actcagtcat cattacttgt gtttcgtctc ttcctcccac    900

atctccttgt ataactgtct tttggggagg ggtgaagtga tagtaagaaa aacaacagca    960

ctttgaaaaa gggacagggg gagaaacaag aaggggagaa agagttgggg agagctcttg   1020

ggtgatgggg agatagcact ggggatgttc tggagcctga cagaactgtg tggtccctcc   1080

agctggagat gctgggaaaa caggaaggga ttcgggagac ggcagggatg aagttggctc   1140

atgaaatgca gggctccctt agcactttac aaataccagc ttacaaacac tccacagtca   1200

tcaggaaacc cttgatggat gctgcacaga gatcgaagtt caggagcagc accaatattc   1260

atccggggca attggagtga gagcagcaca ggatcacagc ctgatttggc ctcagaggct   1320

ttcttatctc ttgcaagatc tggaagccat gcaaaaggtg tcatggggag aggcgctgat   1380

gtcaggcatt tatgggacca ctgagtgggg gcaaagaggc aggagaaaaa gccagtgatg   1440

atgggtcgac acctgcaggt agacccattt gcaggttatt agaaactagc ttatttatcc   1500

agcttttttt tttttttttt tctgggcact gggcactgga attctcctgg ttgtaggcaa   1560

gctgggggac agggaggtga gagctggaat agtcattctg aagtgtgata tttattggac   1620

cccatactag gtgactgatg gagaggggct accactcttc cagctaaact ccgctctggt   1680

tgggacccag caattatttt ccatagcgaa gtgttaataa aatatctgtt actcccaaca   1740

caacctcctg ggggaaggga cctgtctgtc tgcttcaact ttggatcctc agtgcccaca   1800

tcaggatacc tggcctgagg tgagtgctgt agaaatagct gttgaatgaa tgcatgaggg   1860

cctgctctgc ctgagggctg gggacagatt gggtgttttc tgtgtcccct ccagagcatc   1920

cggtgaccca gttttaggtc tcaaggtcac tgccaagaaa gagaagctgc taaagtgaca   1980

cctctgtgca cccacatgac ttaacacaaa agttaacagg agctcttcaa aaacaagcct   2040

ctcgagtgtc tgtctcctgt tttccctgag gacagcatca gtggcatcag ataggggttg   2100

gggctgggtg acctgctggt cctcagccat cactgtggcc cagaggtcat ttaagcagct   2160

ctctgcttag cagacaggca gagggaatag atggaaggta caggtaaaca ctgcatgtgg   2220

ccaccgcgag gataccccgg agcctgggaa acagacaggg acgtcgtaaa accaacacat   2280

aatggaccag tgcagagaca ggcaaaacca gtcagaagaa ataggatggt gcctagccca   2340

gggacacctg acttaaggta tttttgtttg tttgttttgt tttttgagac aggggtctct   2400

ctctgtcacc caggctggag tgcagtggca tactcactgc tcactgcagt ctcaacctcc   2460

caggcttaag cgatcctccc acctcagcct ccttagtagt agctgggact acaggtgtgc   2520

accaacacat ccagttcatt tttgtatttt tttgtagagg tggagtttcg ccatgttgct   2580

caggctggtc tcgaactggg ctcaagcgat ctgcccgcct cggcctccca aagtgtgggg   2640

attacaggcg tgagccacca cacctcgttg acctaaggta ttaactaaag aaagcaggtg   2700

attctcaggg gggctatgaa agcagcatgc ctaagggaca ggaacgtacc atgaaggtgt   2760

tgtcttttga ggctcagtcc aggagaagca ggtcttttag acccaatgac aacgctccct   2820

agtgtgcagg tgcgtctctc tgatgacaaa aggcagtgtg attgtgatat tttatatata   2880

tatagttttt gttattgttg ttttggggac aggtctcact ctgtcaccca gactggagtg   2940

cagtggtaag aatacggctc actgcagcct caaaatccca gtttcaagcg atcctcccac   3000

ctcagcttcc tgagtagctg taactacagg catgcaccac ctggctaatt tttcaaattt   3060

ttttatggag actgggtctc attatgttgc ccaggctggt ctcaaattcc tgggtttagg   3120

caatcctcct gcctcggcct ccctcaatac tgaggttaca ggcgtgagcc actgcaccaa   3180

gcctatattt tgttttttgt tcacggttcc tggcttataa ctcccatggc ccttgttaca   3240

gtaaacacga tctccctccc tgacattctt ctaccctcct ttcacctgcc cacagcagga   3300

ctttaatctg attctgcgtg taatctcatt gcagagaggg tcctgccggt attaccctgg   3360

aggaaggaat gctgcacaga ggccgagagg aatttgaaca gactggcctt gctgggtttt   3420

tatctctttt tgtccaatcc cattttgaca cagttgtcca tgctccaatc atgcttatcc   3480

aatgaagttt ccataacagg cctgagagga cagggttcag gagcttccgg acagctgagc   3540

aggtggaggt tcctggaggg tggtgtgcca gggagggtgt ggaagctctg ccccttcccc   3600

cataccttgt cctatgcatt cctttatctg catccttcat tttattttat ttttttttga   3660

gacggagtct tgctcttgtc gtccaggctg gaatgcagtg gtgcgcgatc ttggcgcact   3720

gcaacctccg cctcccgagt tcaagagatt ctcttgcctg agcctcccga gtagctggga   3780

ttacaggcac ccgccaccat ccctggctaa tttttgtatt tttagtagag atggggtttc   3840

accatgttgg ccaggttagt cttgaactcc tgacctcagg tgatccaccc acctcagcct   3900

cccaaagtgc tgagattaca ggcgtgagcc acagtgcccg gcctgtatcc tttataatat   3960

cttttataaa caaccaatca gtaaatgtgt tactctgact tctgtgagct gctctagcaa   4020

attaatcaaa tccacagaag ggtcatggga accccaactt gaagcctgtc cgtcagaagt   4080

tccagagtcc tggacttgtg actggtgtct gaagtgggca agtcttgggg actgagcccc   4140

tagcctgtgg gatctgatgc tatctccaca tagatagcaa tggaattgaa ttggcgggca   4200

cctggctggt gtctgctgca gagctcattg tttgcttagt ggtggagaga agtctccctc   4260

cacatgtggt cacagcatct tctgtctgtg ttgattgctt ttgatgttga tcgagagaac   4320

aggaaaaagc acattgaatg tctcaatgat gaagatgaca ataatctggc ttctaggttg   4380

ttatgcggca ggcaacagct gtgcagatcc taataatcta ctctgggtga cagtttaaca   4440

caggggttgg caaatgtggc ccacttccta tttttataaa taaagtttta ttgaaacatg   4500


<210>  5368
<211>  67
<212>  PRT
<213>  Homosapiens

<400>  5368

Met Gly Ser Pro Glu Glu Arg Cys Pro Pro Gln Arg Leu Leu Asp Arg 
1               5                   10                  15      


Thr Gly Glu Arg Val Gln Ile Arg Leu Leu Asn Ala Gly Ala Leu Gln 
            20                  25                  30          


Leu Leu Asn Ser Gly Arg Ala Arg Glu Met Leu Pro Gly Trp Val Ser 
        35                  40                  45              


Pro Phe Asn Thr Ser Trp Val Asp Phe Ser His Arg Phe Ser Gly Phe 
    50                  55                  60                  


Ala Glu Leu 
65          


<210>  5369
<211>  922
<212>  DNA
<213>  Homosapiens

<400>  5369
aggaagagga agagcgcggc cggcggcgct gcgctgagag caggggcccg gccaaggcga     60

gtgccgcgcg ggccaccatg gccacggacg agctggccac caagctgagc cggcggctgc    120

agatggaggg cgagggcggc ggcgagaccc cggagcagcc cgggctgaac ggggcagcgg    180

cggcggcggc gggggcaccc gacgaggcgg ccgaggcgct gggcagcgcg gactgcgagc    240

tgagcgccaa gctgctgcgg cgcgcagacc tcaaccaggg catcggcgag ccccagtcgc    300

ccagccgccg cgtcttcaac ccctacaccg agttcaagga gttctccagg aagcagatca    360

aggacatgga gaagatgttc aagcagtatg atgccgggcg ggacggcttc atcgacctga    420

tggagctaaa actcatgatg gagaaacttg gggcccctca gacccacctg ggcctgaaaa    480

acatgatcaa ggaggtggat gaggactttg acagcaagct gagcttccgg gagttcctcc    540

tgatcttccg caaggcggcg gccggggagc ttcaggagga cagcgggctg tgcgtgctgg    600

cccgcctctc tgagatcgac gtctccagtg agggtgtcaa gggggccaag agcttctttg    660

aggccaaggt ccaggccatc aacgtgtcca gccgcttcga ggaggagatc aaggcagagc    720

aggaggaaag gaagaagcag gcggaggaga tgaagcagcg gaaagcggcc ttcaaggagc    780

tgcagtccac ctttaagtag cgggggctgc agccgaccgc cctgctccgg ccccagtgtg    840

gtgggcgagg gtggcgcatg ggaggccgag cctgaatcct tgcctgtgtc tgacgggacc    900

actactaaaa acctaaaaat at                                             922


<210>  5370
<211>  240
<212>  PRT
<213>  Homosapiens

<400>  5370

Met Ala Thr Asp Glu Leu Ala Thr Lys Leu Ser Arg Arg Leu Gln Met 
1               5                   10                  15      


Glu Gly Glu Gly Gly Gly Glu Thr Pro Glu Gln Pro Gly Leu Asn Gly 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Gly Ala Pro Asp Glu Ala Ala Glu Ala Leu 
        35                  40                  45              


Gly Ser Ala Asp Cys Glu Leu Ser Ala Lys Leu Leu Arg Arg Ala Asp 
    50                  55                  60                  


Leu Asn Gln Gly Ile Gly Glu Pro Gln Ser Pro Ser Arg Arg Val Phe 
65                  70                  75                  80  


Asn Pro Tyr Thr Glu Phe Lys Glu Phe Ser Arg Lys Gln Ile Lys Asp 
                85                  90                  95      


Met Glu Lys Met Phe Lys Gln Tyr Asp Ala Gly Arg Asp Gly Phe Ile 
            100                 105                 110         


Asp Leu Met Glu Leu Lys Leu Met Met Glu Lys Leu Gly Ala Pro Gln 
        115                 120                 125             


Thr His Leu Gly Leu Lys Asn Met Ile Lys Glu Val Asp Glu Asp Phe 
    130                 135                 140                 


Asp Ser Lys Leu Ser Phe Arg Glu Phe Leu Leu Ile Phe Arg Lys Ala 
145                 150                 155                 160 


Ala Ala Gly Glu Leu Gln Glu Asp Ser Gly Leu Cys Val Leu Ala Arg 
                165                 170                 175     


Leu Ser Glu Ile Asp Val Ser Ser Glu Gly Val Lys Gly Ala Lys Ser 
            180                 185                 190         


Phe Phe Glu Ala Lys Val Gln Ala Ile Asn Val Ser Ser Arg Phe Glu 
        195                 200                 205             


Glu Glu Ile Lys Ala Glu Gln Glu Glu Arg Lys Lys Gln Ala Glu Glu 
    210                 215                 220                 


Met Lys Gln Arg Lys Ala Ala Phe Lys Glu Leu Gln Ser Thr Phe Lys 
225                 230                 235                 240 


<210>  5371
<211>  2281
<212>  DNA
<213>  Homosapiens

<400>  5371
aagaggaaga gcgcggccgg cggcgctgcg ctgagagcag gggcccggcc aaggcgagtg     60

ccgcgcgggc caccatggcc acggacgagc tggccaccaa gctgagccgg cggctgcaga    120

tggagggcga gggcggcggc gagaccccgg agcagcccgg gctgaacggg gcagcggcgg    180

cggcggcggg ggcacccgac gaggcggccg aggcgctggg cagcgcggac tgcgagctga    240

gcgccaagct gctgcggcgc gcagacctca accagggcat cggcgagccc cagtcgccca    300

gccgccgcgt cttcaacccc tacaccgagt tcaaggagtt ctccaggaag cagatcaagg    360

acatggagaa gatgttcaag cagtatgatg ccgggcggga cggcttcatc gacctgatgg    420

agctaaaact catgatggag aaacttgggg cccctcagac ccacctgggc ctgaaaaaca    480

tgatcaagga ggtggatgag gactttgaca gcaagctgag cttccgggag ttcctcctga    540

tcttccgcaa ggcggcggcc ggggagcttc aggaggacag cgggctgtgc gtgctggccc    600

gcctctctga gatcgacgtc tccagtgagg gtgtcaaggg ggccaagagc ttctttgagg    660

ccaaggtcca ggccatcaac gtgtccagcc gcttcgagga ggagatcaag gcagagcagg    720

aggaaaggaa gaagcaggcg gaggagatga agcagcggaa agcggccttc aaggagctgc    780

agtccacctt taagtagcgg gggctgcagc cgaccgccct gctccggccc cagtgtggtg    840

ggcgagggtg gcgcatggga ggccgagcct gaatccttgc ctgtgtctga cgggaccact    900

actaaaaacc taaaaatatc tgtgaatgga gcaagttcag gggtcttatg gaggtggccc    960

ggcccctccc cgctcccttc cactctgcac gaggccgcca caccggcgct ggctccctgc   1020

ccggcccggc cctccctggc aatccctggg ctctcttgca cccctaactg ccccctgcct   1080

gctccggcac tgccccaggc ccagctcctg gccctaggtc cctcccagcc ccatgtgcct   1140

gccgcctgcc ctccacacat ccctgtcccc ccaacccggg aacccctgcc ctcctccagc   1200

aggccgcacc gcccctgggg ccccctgcca gccccttccc aggctgggag acggcagaag   1260

agatagaatc agggctgccc ccacagagtg ggacccaagg ggctaattgg aggcacgagg   1320

ggacccctcc ccagggcctt ttcctcctct gcgtcttcca tctactgaaa tgggagaggg   1380

ggtggggagc ttctgttctg gtgaagggac ccgggcaggc ccccagcacc ccatgctgac   1440

ttggagaacc ccagatctct ggggcccagc caggcagggt gtgggggcag ctgtgccaat   1500

ctacctcaca ggcccacccc ctgccgggca tgccgtggga tcatgggcag ggaaggctct   1560

gggggtcgga gacaccgctg cttagcaccc ccagccagaa caccctgagg gtctcggggc   1620

tctggagaga gtggggcggg aggaagaatt ggcaccttcc tagggaagga gacgagcgct   1680

tcgccttgat tctccgagaa gcctccgaga agtgctttaa gtgtgtttgc atgcgccagg   1740

cggtgggcag cgggggcctg tccagccctc tcccgccatc cttccccaag tgacgtccac   1800

tgccttgtca ccagcgacct gcctgtcatg cccaccccct gaggaagcat ggggacccta   1860

acaccctggt gccctgcacc agacaggccg tggtcaggcc caggccaccg gccgggttct   1920

gccacagctt cccacgtgct tgctgacatg cgtgtgcctg tgtgtggtgt ctgttgctgt   1980

gtcgtgaaac tgtgaccatc actcagtcca aacaagtgag tggccctcga ggccacagtt   2040

atgcaacttt cagtgtgtgt cataacgacg tcactgcttt ttaaactcga taactcttta   2100

ttttagtaaa atgcccagga gtcctggaag ctacgcggac ttgcagaggt tttatttttt   2160

ggccttagaa tctgcagaaa ttaggaggca ccgagcccag cgcagcagcc tcggacccgg   2220

attgcgtttg ccttagcgga tatgtttata cagatgaata taaaatgttt ttttctttgg   2280

g                                                                   2281


<210>  5372
<211>  240
<212>  PRT
<213>  Homosapiens

<400>  5372

Met Ala Thr Asp Glu Leu Ala Thr Lys Leu Ser Arg Arg Leu Gln Met 
1               5                   10                  15      


Glu Gly Glu Gly Gly Gly Glu Thr Pro Glu Gln Pro Gly Leu Asn Gly 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Gly Ala Pro Asp Glu Ala Ala Glu Ala Leu 
        35                  40                  45              


Gly Ser Ala Asp Cys Glu Leu Ser Ala Lys Leu Leu Arg Arg Ala Asp 
    50                  55                  60                  


Leu Asn Gln Gly Ile Gly Glu Pro Gln Ser Pro Ser Arg Arg Val Phe 
65                  70                  75                  80  


Asn Pro Tyr Thr Glu Phe Lys Glu Phe Ser Arg Lys Gln Ile Lys Asp 
                85                  90                  95      


Met Glu Lys Met Phe Lys Gln Tyr Asp Ala Gly Arg Asp Gly Phe Ile 
            100                 105                 110         


Asp Leu Met Glu Leu Lys Leu Met Met Glu Lys Leu Gly Ala Pro Gln 
        115                 120                 125             


Thr His Leu Gly Leu Lys Asn Met Ile Lys Glu Val Asp Glu Asp Phe 
    130                 135                 140                 


Asp Ser Lys Leu Ser Phe Arg Glu Phe Leu Leu Ile Phe Arg Lys Ala 
145                 150                 155                 160 


Ala Ala Gly Glu Leu Gln Glu Asp Ser Gly Leu Cys Val Leu Ala Arg 
                165                 170                 175     


Leu Ser Glu Ile Asp Val Ser Ser Glu Gly Val Lys Gly Ala Lys Ser 
            180                 185                 190         


Phe Phe Glu Ala Lys Val Gln Ala Ile Asn Val Ser Ser Arg Phe Glu 
        195                 200                 205             


Glu Glu Ile Lys Ala Glu Gln Glu Glu Arg Lys Lys Gln Ala Glu Glu 
    210                 215                 220                 


Met Lys Gln Arg Lys Ala Ala Phe Lys Glu Leu Gln Ser Thr Phe Lys 
225                 230                 235                 240 


<210>  5373
<211>  2427
<212>  DNA
<213>  Homosapiens

<400>  5373
aagaggaaga gcgcggccgg cggcgctgcg ctgagagcag gggcccggcc aaggcgagtg     60

ccgcgcgggc caccatggcc acggacgagc tggccaccaa gctgagccgg cggctgcaga    120

tggagggcga gggcggcggc gagaccccgg agcagcccgg gctgaacggg gcagcggcgg    180

cggcggcggg ggcacccgac gaggcggccg aggcgctggg cagcgcggac tgcgagctga    240

gcgccaagct gctgcggcgc gcagacctca accagggcat cggcgagccc cagtcgccca    300

gccgccgcgt cttcaacccc tacaccgagt tcaaggagtt ctccaggaag cagatcaagg    360

acatggagaa gatgttcaag cagtatgatg ccgggcggga cggcttcatc gacctgatgg    420

agctaaaact catgatggag aaacttgggg cccctcagac ccacctgggc ctgaaaaaca    480

tgatcaagga ggtggatgag gactttgaca gcaagctgag cttccgggag ttcctcctga    540

tcttccgcaa ggcggcggcc ggggagcttc aggaggacag cgggctgtgc gtgctggccc    600

gcctctctga gatcgacgtc tccagtgagg gtgtcaaggg ggccaagagc ttctttgagg    660

ccaaggtcca ggccatcaac gtgtccagcc gcttcgagga ggagatcaag gcagagcagg    720

aggaaaggaa gaagcaggcg gaggagatga agcagcggaa agcggccttc aaggagctgc    780

agtccacctt taagtagcgg gggctgcagc cgaccgccct gctccggccc cagtgtggtg    840

ggcgagggtg gcgcatggga ggccgagcct gaatccttgc ctgtgtctga cgggaccact    900

actaaaaacc taaaaatatc tgtgaatgga gcaagttcag gggtcttatg gaggtggccc    960

ggcccctccc cgctcccttc cactctgcac gaggccgcca caccggcgct ggctccctgc   1020

ccggcccggc cctccctggc aatccctggg ctctcttgca cccctaactg ccccctgcct   1080

gctccggcac tgccccaggc ccagctcctg gccctaggtc cctcccagcc ccatgtgcct   1140

gccgcctgcc ctccacacat ccctgtcccc ccaacccggg aacccctgcc ctcctccagc   1200

aggccgcacc gcccctgggg ccccctgcca gccccttccc aggctgggag acggcagaag   1260

agatagaatc agggctgccc ccacagagtg ggacccaagg ggctaattgg aggcacgagg   1320

ggacccctcc ccagggcctt ttcctcctct gcgtcttcca tctactgaaa tgggagaggg   1380

ggtggggagc ttctgttctg gtgaagggac ccgggcaggc ccccagcacc ccatgctgac   1440

ttggagaacc ccagatctct ggggcccagc caggcagggt gtgggggcag ctgtgccaat   1500

ctacctcaca ggcccacccc ctgccgggca tgccgtggga tcatgggcag ggaaggctct   1560

gggggtcgga gacaccgctg cttagcaccc ccagccagaa caccctgagg gtctcggggc   1620

tctggagaga gtggggcggg aggaagaatt ggcaccttcc tagggaagga gacgagcgct   1680

tcgccttgat tctccgagaa gcctccgaga agtgctttaa gtgtgtttgc atgcgccagg   1740

cggtgggcag cgggggcctg tccagccctc tcccgccatc cttccccaag tgacgtccac   1800

tgccttgtca ccagcgacct gcctgtcatg cccaccccct gaggaagcat ggggacccta   1860

acaccctggt gccctgcacc agacaggccg tggtcaggcc caggccaccg gccgggttct   1920

gccacagctt cccacgtgct tgctgacatg cgtgtgcctg tgtgtggtgt ctgttgctgt   1980

gtcgtgaaac tgtgaccatc actcagtcca aacaagtgag tggccctcga ggccacagtt   2040

atgcaacttt cagtgtgtgt cataacgacg tcactgcttt ttaaactcga taactcttta   2100

ttttagtaaa atgcccagga gtcctggaag ctacgcggac ttgcagaggt tttatttttt   2160

ggccttagaa tctgcagaaa ttaggaggca ccgagcccag cgcagcagcc tcggacccgg   2220

attgcgtttg ccttagcgga tatgtttata cagatgaata taaaatgttt ttttctttgg   2280

gctttttgct tcttttttcc cccccttctc accttccctt ctccccgacc ccacccccca   2340

aaaaagctac ttcttcattc cgtggtacga ttattttttt taactaaagg aagataaaat   2400

tctatattct tatgtgtgta tggttct                                       2427


<210>  5374
<211>  240
<212>  PRT
<213>  Homosapiens

<400>  5374

Met Ala Thr Asp Glu Leu Ala Thr Lys Leu Ser Arg Arg Leu Gln Met 
1               5                   10                  15      


Glu Gly Glu Gly Gly Gly Glu Thr Pro Glu Gln Pro Gly Leu Asn Gly 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Gly Ala Pro Asp Glu Ala Ala Glu Ala Leu 
        35                  40                  45              


Gly Ser Ala Asp Cys Glu Leu Ser Ala Lys Leu Leu Arg Arg Ala Asp 
    50                  55                  60                  


Leu Asn Gln Gly Ile Gly Glu Pro Gln Ser Pro Ser Arg Arg Val Phe 
65                  70                  75                  80  


Asn Pro Tyr Thr Glu Phe Lys Glu Phe Ser Arg Lys Gln Ile Lys Asp 
                85                  90                  95      


Met Glu Lys Met Phe Lys Gln Tyr Asp Ala Gly Arg Asp Gly Phe Ile 
            100                 105                 110         


Asp Leu Met Glu Leu Lys Leu Met Met Glu Lys Leu Gly Ala Pro Gln 
        115                 120                 125             


Thr His Leu Gly Leu Lys Asn Met Ile Lys Glu Val Asp Glu Asp Phe 
    130                 135                 140                 


Asp Ser Lys Leu Ser Phe Arg Glu Phe Leu Leu Ile Phe Arg Lys Ala 
145                 150                 155                 160 


Ala Ala Gly Glu Leu Gln Glu Asp Ser Gly Leu Cys Val Leu Ala Arg 
                165                 170                 175     


Leu Ser Glu Ile Asp Val Ser Ser Glu Gly Val Lys Gly Ala Lys Ser 
            180                 185                 190         


Phe Phe Glu Ala Lys Val Gln Ala Ile Asn Val Ser Ser Arg Phe Glu 
        195                 200                 205             


Glu Glu Ile Lys Ala Glu Gln Glu Glu Arg Lys Lys Gln Ala Glu Glu 
    210                 215                 220                 


Met Lys Gln Arg Lys Ala Ala Phe Lys Glu Leu Gln Ser Thr Phe Lys 
225                 230                 235                 240 


<210>  5375
<211>  1109
<212>  DNA
<213>  Homosapiens

<400>  5375
aggtccaggc catcaacgtg tccagccgct tcgaggagga gatcaaggca gagcaggagg     60

aaaggaagaa gcaggcggag gagatgaagc agcggaaagc ggccttcaag gagctgcagt    120

ccacctttaa gtagcggggg ctgcagccga ccgccctgct ccggccccag tgtggtgggc    180

gagggtggcg catgggaggc cgagcctgaa tccttgcctg tgtctgacgg gaccactact    240

aaaaacctaa aaatatctgt gaatggagca agttcagggg tcttatggag gtggcccggc    300

ccctccccgc tcccttccac tctgcacgag gccgccacac cggcgctggc tccctgcccg    360

gcccggccct ccctggcaat ccctgggctc tcttgcaccc ctaactgccc cctgcctgct    420

ccggcactgc cccaggccca gctcctggcc ctaggtccct cccagcccca tgtgcctgcc    480

gcctgccctc cacacatccc tgtcccccca acccgggaac ccctgccctc ctccagcagg    540

ccgcaccgcc cctggggccc cctgccagcc ccttcccagg ctgggagacg gcagaagaga    600

tagaatcagg gctgccccca cagagtggga cccaaggggc taattggagg cacgagggga    660

cccctcccca gggccttttc ctcctctgcg tcttccatct actgaaatgg gagagggggt    720

ggggagcttc tgttctggtg aagggacccg ggcaggcccc cagcacccca tgctgacttg    780

gagaacccca gatctctggg gcccagccag gcagggtgtg ggggcagctg tgccaatcta    840

cctcacaggc ccaccccctg ccgggcatgc cgtgggatca tgggcaggga aggctctggg    900

ggtcggagac accgctgctt agcaccccca gccagaacac cctgagggtc tcggggctct    960

ggagagagtg gggcgggagg aagaattggc accttcctag ggaaggagac gagcgcttcg   1020

ccttgattct tctccccgac cccacccccc aaaaaagcta cttcttcatt ccgtggtacg   1080

attatttttt ttaactaaag gaagataaa                                     1109


<210>  5376
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  5376

Met Pro Trp Asp His Gly Gln Gly Arg Leu Trp Gly Ser Glu Thr Pro 
1               5                   10                  15      


Leu Leu Ser Thr Pro Ser Gln Asn Thr Leu Arg Val Ser Gly Leu Trp 
            20                  25                  30          


Arg Glu Trp Gly Gly Arg Lys Asn Trp His Leu Pro Arg Glu Gly Asp 
        35                  40                  45              


Glu Arg Phe Ala Leu Ile Leu Leu Pro Asp Pro Thr Pro Gln Lys Ser 
    50                  55                  60                  


Tyr Phe Phe Ile Pro Trp Tyr Asp Tyr Phe Phe 
65                  70                  75  


<210>  5377
<211>  997
<212>  DNA
<213>  Homosapiens

<400>  5377
cctccccgct cccttccact ctgcacgagg ccgccacacc ggcgctggct ccctgcccgg     60

cccggccctc cctggcaatc cctgggctct cttgcacccc taactgcccc ctgcctgctc    120

cggcactgcc ccaggccccc agcaccccat gctgacttgg agaaccccag atctctgggg    180

cccagccagg cagggtgtgg gggcagctgt gccaatctac ctcacaggcc caccccctgc    240

cgggcatgcc gtgggatcat gggcagggaa ggctctgggg gtcggagaca ccgctgctta    300

gcacccccag ccagaacacc ctgagggtct cggggctctg gagagagtgg ggcgggagga    360

agaattggca ccttcctagg gaaggagacg agcgcttcgc cttgattctc cgagaagcct    420

ccgagaagtg ctttaagtgt gtttgcatgc gccaggcggt gggcagcggg ggcctgtcca    480

gccctctccc gccatccttc cccaagtgac gtccactgcc ttgtcaccag cgacctgcct    540

gtcatgccca ccccctgagg aagcatgggg accctaacac cctggtgccc tgcaccagac    600

aggccgtggt caggcccagg ccaccggccg ggttctgcca cagcttccca cgtgcttgct    660

gacatgcgtg tgcctgtgtg tggtgtctgt tgctgtgtcg tgaaactgtg accatcactc    720

agtccaaaca agtgagtggc cctcgaggcc acagttatgc aactttcagt gtgtgtcata    780

acgacgtcac tgctttttaa actcgataac tctttatttt agtaaaatgc ccaggagtcc    840

tggaagctac gcggacttgc agaggtttta ttttttggcc ttagaatctg cagaaattag    900

gaggcaccga gcccagcgca gcagcctcgg acccggattg cgtttgcctt agcggatatg    960

tttatacaga tgaatataaa atgttttttt ctttggg                             997


<210>  5378
<211>  87
<212>  PRT
<213>  Homosapiens

<400>  5378

Met Pro Trp Asp His Gly Gln Gly Arg Leu Trp Gly Ser Glu Thr Pro 
1               5                   10                  15      


Leu Leu Ser Thr Pro Ser Gln Asn Thr Leu Arg Val Ser Gly Leu Trp 
            20                  25                  30          


Arg Glu Trp Gly Gly Arg Lys Asn Trp His Leu Pro Arg Glu Gly Asp 
        35                  40                  45              


Glu Arg Phe Ala Leu Ile Leu Arg Glu Ala Ser Glu Lys Cys Phe Lys 
    50                  55                  60                  


Cys Val Cys Met Arg Gln Ala Val Gly Ser Gly Gly Leu Ser Ser Pro 
65                  70                  75                  80  


Leu Pro Pro Ser Phe Pro Lys 
                85          


<210>  5379
<211>  1143
<212>  DNA
<213>  Homosapiens

<400>  5379
cctccccgct cccttccact ctgcacgagg ccgccacacc ggcgctggct ccctgcccgg     60

cccggccctc cctggcaatc cctgggctct cttgcacccc taactgcccc ctgcctgctc    120

cggcactgcc ccaggccccc agcaccccat gctgacttgg agaaccccag atctctgggg    180

cccagccagg cagggtgtgg gggcagctgt gccaatctac ctcacaggcc caccccctgc    240

cgggcatgcc gtgggatcat gggcagggaa ggctctgggg gtcggagaca ccgctgctta    300

gcacccccag ccagaacacc ctgagggtct cggggctctg gagagagtgg ggcgggagga    360

agaattggca ccttcctagg gaaggagacg agcgcttcgc cttgattctc cgagaagcct    420

ccgagaagtg ctttaagtgt gtttgcatgc gccaggcggt gggcagcggg ggcctgtcca    480

gccctctccc gccatccttc cccaagtgac gtccactgcc ttgtcaccag cgacctgcct    540

gtcatgccca ccccctgagg aagcatgggg accctaacac cctggtgccc tgcaccagac    600

aggccgtggt caggcccagg ccaccggccg ggttctgcca cagcttccca cgtgcttgct    660

gacatgcgtg tgcctgtgtg tggtgtctgt tgctgtgtcg tgaaactgtg accatcactc    720

agtccaaaca agtgagtggc cctcgaggcc acagttatgc aactttcagt gtgtgtcata    780

acgacgtcac tgctttttaa actcgataac tctttatttt agtaaaatgc ccaggagtcc    840

tggaagctac gcggacttgc agaggtttta ttttttggcc ttagaatctg cagaaattag    900

gaggcaccga gcccagcgca gcagcctcgg acccggattg cgtttgcctt agcggatatg    960

tttatacaga tgaatataaa atgttttttt ctttgggctt tttgcttctt ttttcccccc   1020

cttctcacct tcccttctcc ccgaccccac cccccaaaaa agctacttct tcattccgtg   1080

gtacgattat tttttttaac taaaggaaga taaaattcta tattcttatg tgtgtatggt   1140

tct                                                                 1143


<210>  5380
<211>  87
<212>  PRT
<213>  Homosapiens

<400>  5380

Met Pro Trp Asp His Gly Gln Gly Arg Leu Trp Gly Ser Glu Thr Pro 
1               5                   10                  15      


Leu Leu Ser Thr Pro Ser Gln Asn Thr Leu Arg Val Ser Gly Leu Trp 
            20                  25                  30          


Arg Glu Trp Gly Gly Arg Lys Asn Trp His Leu Pro Arg Glu Gly Asp 
        35                  40                  45              


Glu Arg Phe Ala Leu Ile Leu Arg Glu Ala Ser Glu Lys Cys Phe Lys 
    50                  55                  60                  


Cys Val Cys Met Arg Gln Ala Val Gly Ser Gly Gly Leu Ser Ser Pro 
65                  70                  75                  80  


Leu Pro Pro Ser Phe Pro Lys 
                85          


<210>  5381
<211>  902
<212>  DNA
<213>  Homosapiens

<400>  5381
ggtcagccag tcctgagcac ctaaccatgt tgggcatcac tgtcctcgct gcgctcttgg     60

cctgtgcctc cagctgtggg gtgcccagct tcccgcccaa cctatccgcc cgagtggtgg    120

gaggagagga tgcccggccc cacagctggc cctggcagat ctccctccag tacctcaaga    180

acgacacgtg gaggcatacg tgtggcggga ctttgattgc tagcaacttc gtcctcactg    240

ccgcccactg catcagcaac acccggacct accgtgtggc cgtgggaaag aacaacctgg    300

aggtggaaga cgaagaagga tccctgtttg tgggtgtgga caccatccac gtccacaaga    360

gatggaatgc cctcctgttg cgcaatgata ttgccctcat caagcttgca gagcatgtgg    420

agctgagtga caccatccag gtggcctgcc tgccagagaa ggactccctg ctccccaagg    480

actacccctg ctatgtcacc ggctggggcc gcctctggac caacggcccc attgctgata    540

agctgcagca gggcctgcag cccgtggtgg atcacgccac gtgctccagg attgactggt    600

ggggcttcag ggtgaagaaa accatggtgt gcgctggggg cgatggcgtc atctcagcct    660

gcaatgggga ctccggtggc ccactgaact gccagttgga gaacggttcc tgggaggtgt    720

ttggcatcgt cagctttggc tcccggcggg gctgcaacac ccgcaagaag ccggtagtct    780

acacccgggt gtccgcctac atcgactgga tcaacgagaa aatgcagctg tgatttgttg    840

ctgggagcgg cggcagcgag tccctgcaac agcaataaac ttccttctcc tcgggccacc    900

tg                                                                   902


<210>  5382
<211>  268
<212>  PRT
<213>  Homosapiens

<400>  5382

Met Leu Gly Ile Thr Val Leu Ala Ala Leu Leu Ala Cys Ala Ser Ser 
1               5                   10                  15      


Cys Gly Val Pro Ser Phe Pro Pro Asn Leu Ser Ala Arg Val Val Gly 
            20                  25                  30          


Gly Glu Asp Ala Arg Pro His Ser Trp Pro Trp Gln Ile Ser Leu Gln 
        35                  40                  45              


Tyr Leu Lys Asn Asp Thr Trp Arg His Thr Cys Gly Gly Thr Leu Ile 
    50                  55                  60                  


Ala Ser Asn Phe Val Leu Thr Ala Ala His Cys Ile Ser Asn Thr Arg 
65                  70                  75                  80  


Thr Tyr Arg Val Ala Val Gly Lys Asn Asn Leu Glu Val Glu Asp Glu 
                85                  90                  95      


Glu Gly Ser Leu Phe Val Gly Val Asp Thr Ile His Val His Lys Arg 
            100                 105                 110         


Trp Asn Ala Leu Leu Leu Arg Asn Asp Ile Ala Leu Ile Lys Leu Ala 
        115                 120                 125             


Glu His Val Glu Leu Ser Asp Thr Ile Gln Val Ala Cys Leu Pro Glu 
    130                 135                 140                 


Lys Asp Ser Leu Leu Pro Lys Asp Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Trp Thr Asn Gly Pro Ile Ala Asp Lys Leu Gln Gln Gly 
                165                 170                 175     


Leu Gln Pro Val Val Asp His Ala Thr Cys Ser Arg Ile Asp Trp Trp 
            180                 185                 190         


Gly Phe Arg Val Lys Lys Thr Met Val Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Ser Ala Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Leu 
    210                 215                 220                 


Glu Asn Gly Ser Trp Glu Val Phe Gly Ile Val Ser Phe Gly Ser Arg 
225                 230                 235                 240 


Arg Gly Cys Asn Thr Arg Lys Lys Pro Val Val Tyr Thr Arg Val Ser 
                245                 250                 255     


Ala Tyr Ile Asp Trp Ile Asn Glu Lys Met Gln Leu 
            260                 265             


<210>  5383
<211>  747
<212>  DNA
<213>  Homosapiens

<400>  5383
cagccagtcc tgagcaccta accatgttgg gcatcactgt cctcgctgcg ctcttggcct     60

gtgcctccag ctgtggggtg cccagcttcc cgcccaacct atccgcccga gtggtgggag    120

gagaggatgc ccggccccac agctggccct ggcagatctc cctccagtac ctcaagaacg    180

acacgtggag gcatacgtgt ggcgggactt tgattgctag caacttcgtc ctcactgccg    240

cccactgcat cagcaacacc cggacctacc gtgtggccgt gggaaagaac aacctggagg    300

tggaagacga agaaggatcc ctgtttgtgg gtgtggacac catccacgtc cacaagagat    360

ggaatgccct cctgttgcgc aatgatattg ccctcatcaa gcttgcagag catgtggagc    420

tgagtgacac catccaggtg gcctgcctgc cagagaagga ctccctgctc cccaaggact    480

acccctgcta tgtcaccggc tggggccgcc tctggagggg actccggtgg cccactgaac    540

tgccagttgg agaacggttc ctgggaggtg tttggcatcg tcagctttgg ctcccggcgg    600

ggctgcaaca cccgcaagaa gccggtagtc tacacccggg tgtccgccta catcgactgg    660

atcaacgaga aaatgcagct gtgatttgtt gctgggagcg gcggcagcga gtccctgcaa    720

cagcaataaa cttccttctc ctcgggc                                        747


<210>  5384
<211>  240
<212>  PRT
<213>  Homosapiens

<400>  5384

Met Leu Gly Ile Thr Val Leu Ala Ala Leu Leu Ala Cys Ala Ser Ser 
1               5                   10                  15      


Cys Gly Val Pro Ser Phe Pro Pro Asn Leu Ser Ala Arg Val Val Gly 
            20                  25                  30          


Gly Glu Asp Ala Arg Pro His Ser Trp Pro Trp Gln Ile Ser Leu Gln 
        35                  40                  45              


Tyr Leu Lys Asn Asp Thr Trp Arg His Thr Cys Gly Gly Thr Leu Ile 
    50                  55                  60                  


Ala Ser Asn Phe Val Leu Thr Ala Ala His Cys Ile Ser Asn Thr Arg 
65                  70                  75                  80  


Thr Tyr Arg Val Ala Val Gly Lys Asn Asn Leu Glu Val Glu Asp Glu 
                85                  90                  95      


Glu Gly Ser Leu Phe Val Gly Val Asp Thr Ile His Val His Lys Arg 
            100                 105                 110         


Trp Asn Ala Leu Leu Leu Arg Asn Asp Ile Ala Leu Ile Lys Leu Ala 
        115                 120                 125             


Glu His Val Glu Leu Ser Asp Thr Ile Gln Val Ala Cys Leu Pro Glu 
    130                 135                 140                 


Lys Asp Ser Leu Leu Pro Lys Asp Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Trp Arg Gly Leu Arg Trp Pro Thr Glu Leu Pro Val Gly 
                165                 170                 175     


Glu Arg Phe Leu Gly Gly Val Trp His Arg Gln Leu Trp Leu Pro Ala 
            180                 185                 190         


Gly Leu Gln His Pro Gln Glu Ala Gly Ser Leu His Pro Gly Val Arg 
        195                 200                 205             


Leu His Arg Leu Asp Gln Arg Glu Asn Ala Ala Val Ile Cys Cys Trp 
    210                 215                 220                 


Glu Arg Arg Gln Arg Val Pro Ala Thr Ala Ile Asn Phe Leu Leu Leu 
225                 230                 235                 240 


<210>  5385
<211>  1262
<212>  DNA
<213>  Homosapiens

<400>  5385
cagccagtcc tgagcaccta accatgttgg gcatcactgt cctcgctgcg ctcttggcct     60

gtgcctccag ctgtggggtg cccagcttcc cgcccaacct atccgcccga gtggtgggag    120

gagaggatgc ccggccccac agctggccct ggcagatctc cctccagtac ctcaagaacg    180

acacgtggag gcatacgtgt ggcgggactt tgattgctag caacttcgtc ctcactgccg    240

cccactgcat cagcaacacc cggacctacc gtgtggccgt gggaaagaac aacctggagg    300

tggaagacga agaaggatcc ctgtttgtgg gtgtggacac catccacgtc cacaagagat    360

ggaatgccct cctgttgcgc aatgatattg ccctcatcaa gcttgcagag catgtggagc    420

tgagtgacac catccaggtg gcctgcctgc cagagaagga ctccctgctc cccaaggact    480

acccctgcta tgtcaccggc tggggccgcc tctggaccaa cggccccatt gctgataagc    540

tgcagcaggg cctgcagccc gtggtggatc acgccacgtg ctccaggatt gactggtggg    600

gcttcagggt gaagaaaacc atggtgtgcg ctgggggcga tggcgtcatc tcagcctgca    660

atggggactc cggtggccca ctgaactgcc agttggagaa cggttcctgg gaggtgtttg    720

gcatcgtcag ctttggctcc cggcggggct gcaacacccg caagaagccg gtagtctaca    780

cccgggtgtc cgcctacatc gactggatca acgagaaaat gcagctgtga tttgttgctg    840

ggagcggcgg cagcgagtcc ctgcaacagc aataaacttc cttctcctcg ggccacctgg    900

atccttgatt tgtgcagctt ctgttgcttc cctcctctct ggtgctgccc ctttccacac    960

tatggagcca aagagagacc ccactcagcc agtttccccc accctgcatt agacaggtgg   1020

ggaaacagag gccgggagag agggccaagg aaggagcctc ctggggcatt aatgggaggc   1080

agggggctgg ggtggagagc ccagggagtc ctgcgtgaag ccggagggga tgggagtgaa   1140

ggacgcatca gacaccttcc ccgctccatc tcacaagctg cgaacaggtg agaccctgat   1200

gaaatcactc gcttctccga tcctacctcc accgaggggc ctggcaggtc ctcacagccc   1260

cc                                                                  1262


<210>  5386
<211>  268
<212>  PRT
<213>  Homosapiens

<400>  5386

Met Leu Gly Ile Thr Val Leu Ala Ala Leu Leu Ala Cys Ala Ser Ser 
1               5                   10                  15      


Cys Gly Val Pro Ser Phe Pro Pro Asn Leu Ser Ala Arg Val Val Gly 
            20                  25                  30          


Gly Glu Asp Ala Arg Pro His Ser Trp Pro Trp Gln Ile Ser Leu Gln 
        35                  40                  45              


Tyr Leu Lys Asn Asp Thr Trp Arg His Thr Cys Gly Gly Thr Leu Ile 
    50                  55                  60                  


Ala Ser Asn Phe Val Leu Thr Ala Ala His Cys Ile Ser Asn Thr Arg 
65                  70                  75                  80  


Thr Tyr Arg Val Ala Val Gly Lys Asn Asn Leu Glu Val Glu Asp Glu 
                85                  90                  95      


Glu Gly Ser Leu Phe Val Gly Val Asp Thr Ile His Val His Lys Arg 
            100                 105                 110         


Trp Asn Ala Leu Leu Leu Arg Asn Asp Ile Ala Leu Ile Lys Leu Ala 
        115                 120                 125             


Glu His Val Glu Leu Ser Asp Thr Ile Gln Val Ala Cys Leu Pro Glu 
    130                 135                 140                 


Lys Asp Ser Leu Leu Pro Lys Asp Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Trp Thr Asn Gly Pro Ile Ala Asp Lys Leu Gln Gln Gly 
                165                 170                 175     


Leu Gln Pro Val Val Asp His Ala Thr Cys Ser Arg Ile Asp Trp Trp 
            180                 185                 190         


Gly Phe Arg Val Lys Lys Thr Met Val Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Ser Ala Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Leu 
    210                 215                 220                 


Glu Asn Gly Ser Trp Glu Val Phe Gly Ile Val Ser Phe Gly Ser Arg 
225                 230                 235                 240 


Arg Gly Cys Asn Thr Arg Lys Lys Pro Val Val Tyr Thr Arg Val Ser 
                245                 250                 255     


Ala Tyr Ile Asp Trp Ile Asn Glu Lys Met Gln Leu 
            260                 265             


<210>  5387
<211>  315
<212>  DNA
<213>  Homosapiens

<400>  5387
ctccaccttc tgcctggggg ctgggaggcc tggaaggggc tgctgagagc cccaccagcc     60

actgatccac tagtgtgcca ttggatgcct aatagccgtt gcgtggctag catatattga    120

gcacttgcta atttgtgtta ggctccgccc aaggcttcat atatatgacc tcatttcatc    180

ctcatggcaa ccctgtttat tatccctcag ttttccccat ctgtgaaatg gacacctgcc    240

ctgtctcctt actggggagc caatgaaatg acagaggcta gtgaatgggg cagagagggc    300

cattactact actga                                                     315


<210>  5388
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  5388

Met Ala Thr Leu Phe Ile Ile Pro Gln Phe Ser Pro Ser Val Lys Trp 
1               5                   10                  15      


Thr Pro Ala Leu Ser Pro Tyr Trp Gly Ala Asn Glu Met Thr Glu Ala 
            20                  25                  30          


Ser Glu Trp Gly Arg Glu Gly His Tyr Tyr Tyr 
        35                  40              


<210>  5389
<211>  532
<212>  DNA
<213>  Homosapiens

<400>  5389
gcttacagaa ctcccacgga cacaccatga taaggacgct gctgctgtcc actttggtgg     60

ctggagccct cagttgtggg gaccccactt acccacctta tgtgactagg gtggttggcg    120

gtgaagaagc gaggcccaac agctggccct ggcaggtctc cctgcagtac agctccaatg    180

gcaagtggta ccacacctgc ggagggtccc tgatagccaa cagctgggtc ctgacggctg    240

cccactgcat cagctcctcc aggacctacc gcgtggggct gggccggcac aacctctacg    300

ttgcggagtc cggctcgctg gcagtcagtg tctctaagat tgtggtgcac aaggactgga    360

actccaacca aatctccaaa gggttcgttt ctgtctgggt gcacttgggg gtgaggttgt    420

cagggaacag atgggggtct cacagaggca agggtctcaa ccacaccaca ccccctctgc    480

ttcttctaca gggaggggga aggagctctg gcctcttaga tgtggaacca gc            532


<210>  5390
<211>  167
<212>  PRT
<213>  Homosapiens

<400>  5390

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Cys Gly Asp Pro Thr Tyr Pro Pro Tyr Val Thr Arg Val Val Gly Gly 
            20                  25                  30          


Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Ser Ser Asn Gly Lys Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser Ser Ser Arg Thr 
65                  70                  75                  80  


Tyr Arg Val Gly Leu Gly Arg His Asn Leu Tyr Val Ala Glu Ser Gly 
                85                  90                  95      


Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His Lys Asp Trp Asn 
            100                 105                 110         


Ser Asn Gln Ile Ser Lys Gly Phe Val Ser Val Trp Val His Leu Gly 
        115                 120                 125             


Val Arg Leu Ser Gly Asn Arg Trp Gly Ser His Arg Gly Lys Gly Leu 
    130                 135                 140                 


Asn His Thr Thr Pro Pro Leu Leu Leu Leu Gln Gly Gly Gly Arg Ser 
145                 150                 155                 160 


Ser Gly Leu Leu Asp Val Glu 
                165         


<210>  5391
<211>  921
<212>  DNA
<213>  Homosapiens

<400>  5391
cttacagaac tcccacggac acaccatgat aaggacgctg ctgctgtcca ctttggtggc     60

tggagccctc agttgtgggg accccactta cccaccttat gtgactaggg tggttggcgg    120

tgaagaagcg aggcccaaca gctggccctg gcaggtctcc ctgcagtaca gctccaatgg    180

caagtggtac cacacctgcg gagggtccct gatagccaac agctgggtcc tgacggctgc    240

ccactgcatc agctcctcca ggacctaccg cgtggggctg ggccggcaca acctctacgt    300

tgcggagtcc ggctcgctgg cagtcagtgt ctctaagatt gtggtgcaca aggactggaa    360

ctccaaccaa atctccaaag ggaacgacat tgccctgctc aaactggcta accccgtctc    420

cctcaccgac aagatccagc tggcctgcct ccctcctgcc ggcaccattc tacccaacaa    480

ctacccctgc tacgtcacgg gctggggaag gctgcagacc aacggggctg ttcctgatgt    540

cctgcagcag ggccggttgc tggttgtgga ctatgccacc tgctccagct ctgcctggtg    600

gggcagcagc gtgaaaacca gtatgatctg tgctgggggt gatggcgtga tctccagctg    660

caacggagac tctggcgggc cactgaactg tcaggcgtct gacggccggt ggcaggtgca    720

cggcatcgtc agcttcgggt ctcgcctcgg ctgcaactac taccacaagc cctccgtctt    780

cacgcgggtc tccaattaca tcgactggat caattcggtg attgcaaata actaaccaaa    840

agaagtccct gggactgttt cagacttgga aaggtcacag aaggaaaata atataataaa    900

gtgacaacta tgcaaatcac a                                              921


<210>  5392
<211>  269
<212>  PRT
<213>  Homosapiens

<400>  5392

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Cys Gly Asp Pro Thr Tyr Pro Pro Tyr Val Thr Arg Val Val Gly Gly 
            20                  25                  30          


Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Ser Ser Asn Gly Lys Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser Ser Ser Arg Thr 
65                  70                  75                  80  


Tyr Arg Val Gly Leu Gly Arg His Asn Leu Tyr Val Ala Glu Ser Gly 
                85                  90                  95      


Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His Lys Asp Trp Asn 
            100                 105                 110         


Ser Asn Gln Ile Ser Lys Gly Asn Asp Ile Ala Leu Leu Lys Leu Ala 
        115                 120                 125             


Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala Cys Leu Pro Pro 
    130                 135                 140                 


Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Gln Thr Asn Gly Ala Val Pro Asp Val Leu Gln Gln Gly 
                165                 170                 175     


Arg Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser Ser Ala Trp Trp 
            180                 185                 190         


Gly Ser Ser Val Lys Thr Ser Met Ile Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Ser Ser Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Ala 
    210                 215                 220                 


Ser Asp Gly Arg Trp Gln Val His Gly Ile Val Ser Phe Gly Ser Arg 
225                 230                 235                 240 


Leu Gly Cys Asn Tyr Tyr His Lys Pro Ser Val Phe Thr Arg Val Ser 
                245                 250                 255     


Asn Tyr Ile Asp Trp Ile Asn Ser Val Ile Ala Asn Asn 
            260                 265                 


<210>  5393
<211>  582
<212>  DNA
<213>  Homosapiens

<400>  5393
acacaccatg ataaggacgc tgctgctgtc cactttggtg gctggagccc tcagttgtgg     60

ggaccccact tacccacctt atgtgactag ggtggttggc ggtgaagaag cgaggcccaa    120

cagctggccc tggcaggtga gttgaccaca ctgtacttct ccccgtccct gccccactcc    180

ctttacatct cccctttgcc cttccaccat ggcgtctatt gtgctggcaa agtgagtatt    240

gatgggactc agagagcagc acaggcaact ttagcaataa gatatatttc cggctgggcg    300

cagtggctca tgcctgttat cccagcactg tgggaggctg tggtgggcag atcacctgaa    360

gtcaggagtt tgagaccagc ctggccaaca tggtgaaacc tgcctctact aataatacac    420

aagtagccag gtgtggtggc acacgcctgt aatcccagca actggggagg cttaggcagg    480

aggatcgctt gaacccagga ggcagaggtt gcagtgagct gaaattgcac cactgtactc    540

cagcctgggc aacaaagcaa gactctgtct caaaaaaaaa aa                       582


<210>  5394
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  5394

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Cys Gly Asp Pro Thr Tyr Pro Pro Tyr Val Thr Arg Val Val Gly Gly 
            20                  25                  30          


Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser 
        35                  40                  45  


<210>  5395
<211>  923
<212>  DNA
<213>  Homosapiens

<400>  5395
cttacagaac tcccacggac acaccatgat taggaccctg ctgctgtcca ctttggtggc     60

tggagccctc agttgtgggg tctccactta cgcgcctgat atgtctagga tgcttggagg    120

tgaagaagcg aggcccaaca gctggccctg gcaggtctcc ctgcagtaca gctccaatgg    180

ccagtggtac cacacctgcg gagggtccct gatagccaac agctgggtcc tgacggctgc    240

ccactgcatc agctcctccg ggatctaccg cgtgatgctg ggccagcata acctctacgt    300

tgcagagtcc ggctcgctgg ccgtcagtgt ctctaagatt gtggtgcaca aggactggaa    360

ctccgaccag gtctccaaag ggaacgacat tgccctgctc aaactggcta accccgtctc    420

cctcaccgac aagatccagc tggcctgcct ccctcctgcc ggcaccattc tacccaacaa    480

ctacccctgc tacgtcacgg gctggggaag gctgcagacc aacggggctc tccctgatga    540

cctgaagcag ggccagttgc tggttgtgga ctatgccacc tgctccagct ctggctggtg    600

gggcagcacc gtgaagacga atatgatctg tgctgggggt gatggcgtga tatgcacctg    660

caacggagac tccggtgggc cgctgaactg tcaggcatct gacggccggt gggaggtgca    720

tggcatcggc agcctcacgt cggtccttgg ttgcaactac tactacaagc cctccatctt    780

cacgcgggtc tccaactaca acgactggat caattcggtg attgcaaata actaaccaaa    840

agaagtccct gggactgttt cagacttgga aaggtcacag aaggaaaata atattatata    900

aagtgacaac tatgcaaatc aca                                            923


<210>  5396
<211>  269
<212>  PRT
<213>  Homosapiens

<400>  5396

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Cys Gly Val Ser Thr Tyr Ala Pro Asp Met Ser Arg Met Leu Gly Gly 
            20                  25                  30          


Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Ser Ser Asn Gly Gln Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser Ser Ser Gly Ile 
65                  70                  75                  80  


Tyr Arg Val Met Leu Gly Gln His Asn Leu Tyr Val Ala Glu Ser Gly 
                85                  90                  95      


Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His Lys Asp Trp Asn 
            100                 105                 110         


Ser Asp Gln Val Ser Lys Gly Asn Asp Ile Ala Leu Leu Lys Leu Ala 
        115                 120                 125             


Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala Cys Leu Pro Pro 
    130                 135                 140                 


Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Gln Thr Asn Gly Ala Leu Pro Asp Asp Leu Lys Gln Gly 
                165                 170                 175     


Gln Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser Ser Gly Trp Trp 
            180                 185                 190         


Gly Ser Thr Val Lys Thr Asn Met Ile Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Cys Thr Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Ala 
    210                 215                 220                 


Ser Asp Gly Arg Trp Glu Val His Gly Ile Gly Ser Leu Thr Ser Val 
225                 230                 235                 240 


Leu Gly Cys Asn Tyr Tyr Tyr Lys Pro Ser Ile Phe Thr Arg Val Ser 
                245                 250                 255     


Asn Tyr Asn Asp Trp Ile Asn Ser Val Ile Ala Asn Asn 
            260                 265                 


<210>  5397
<211>  756
<212>  DNA
<213>  Homosapiens

<400>  5397
gtagctctta ctacaggcgt gcaccattgc acccagcccc atttattcat gtcttatttc     60

acttgatcct tatcccatcc caggaaggca acaagggtga gaaccctgtg ctcagggagg    120

ttaggtctct tgtccaaggg aaaacgatta tccagagaag agacctggcc agaacctggg    180

tcccctgagt cctagccatg cttcccatgt gccttacttg ctgaagcacc cccggactgc    240

agtgtgaacg tgctgtgcaa tagtgacacg ctgggcttcc ccacaaggct ccaccctgag    300

gtcttttaag ctgtccttat gccagcctat ttcttgtttt ttgggccttt ttttttggag    360

atagggtctc actctgtcgc ccaggctgga gtgcaatgac gcaatcttgg cttattgcag    420

tctcgacctc ctgggctcaa gagatccttc cacctcagcc acctgtaatc ccagctagtt    480

aggaggctga ggcaggagaa ttgcttgaac ccgggaggcg caggttgcag tgagctgaga    540

tcaagccact gtactccagc ctgtgcaaca gagcgagact ccatttgaaa aaaaacaaaa    600

caaaaacaat gattacctct ggagagtgga attggagatg taaaatgagg ggggacttct    660

acttttttac ttgatactct cctgtattct tttaatattt ttacaaagag tatgtattac    720

cttctggaaa aagaataaaa actaaggatt gctgga                              756


<210>  5398
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  5398

Gly Leu Thr Leu Ser Pro Arg Leu Glu Cys Asn Asp Ala Ile Leu Ala 
1               5                   10                  15      


Tyr Cys Ser Leu Asp Leu Leu Gly Ser Arg Asp Pro Ser Thr Ser Ala 
            20                  25                  30          


Thr Cys Asn Pro Ser 
        35          


<210>  5399
<211>  721
<212>  DNA
<213>  Homosapiens

<400>  5399
agggacttct tttggttagt tatttgcaat cacctgcagg acacacacac aagaaaattg     60

tcaggttcac gtaaccacag agctgtgcgt ggcagtttcc tgtctctgtc ctcctgggct    120

aagctactca agtgagtcac aggcagccca cactacagta gctcctgcct gaggagttca    180

gatgatgttt cggagaaaaa gatgcaatca cagcttttca ttgacctgtt agggtcttcc    240

tgtaaagggg gtcttagcca ggagtcctgt gtgggcttca ggtcaggggg ccttcgaacc    300

ccctaaaaat tatatgccaa atgtgcggat ggcatatttt tagatttcat ttgtttctca    360

tcaaaactgc tgtttgcaag gcagttatgc actgtggttg gggctataac tgtttccaga    420

ggctgttgat cagtatctgt taaacttttt tttttttttt ttgagacagt cttgctctgt    480

tgcccagacg agtacatgag ctgagatcaa gccactgtac tccagcctgt gcaacagagc    540

gagactccat ttgaaaaaaa acaaaacaaa aacaatgatt acctctggag agtggaattg    600

gagatgtaaa atgagggggg acttctactt ttttacttga tactctcctg tattctttta    660

atatttttac aaagagtatg tattaccttc tggaaaaaga ataaaaacta aggattgctg    720

g                                                                    721


<210>  5400
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5400

Met Cys Gly Trp His Ile Phe Arg Phe His Leu Phe Leu Ile Lys Thr 
1               5                   10                  15      


Ala Val Cys Lys Ala Val Met His Cys Gly Trp Gly Tyr Asn Cys Phe 
            20                  25                  30          


Gln Arg Leu Leu Ile Ser Ile Cys 
        35                  40  


<210>  5401
<211>  1820
<212>  DNA
<213>  Homosapiens

<400>  5401
gacgcagtgg tggattctgg agcggggcgg tgacgtgggg cgggttctgg ggcggggcgg     60

tgacgcggag cgtgttctgg ggcggcgcgg tgatgggagg cttggccctg ggggcggggc    120

gaggcgcaga ggtgcgtcct gagggcgggg cggtgacgca agagcgactc ctgggggcgg    180

ggcgaggcct tggagatgcg tccggaggcg gtggggagcg aagactgacc cggggccgtg    240

acgcgggggc aggccctggg gcgggggcgg gtcctgggga ctggggcggg cggccgaggc    300

ccggaagcgg actgaggcgg cctggagtct tagttggcta ctcgccatgg acgaagcgga    360

tcggcggctc ctgcggcggt gccggctgcg gctggtggaa gagctgcagg tggaccagct    420

ctgggacgcc ctgctgagcc gcgagctgtt caggccccat atgatcgagg acatccagcg    480

ggcaggctct ggatctcggc gggatcaggc caggcagctg atcatagatc tggagactcg    540

agggagtcag gctcttcctt tgttcatctc ctgcttagag gacacaggcc aggacatgct    600

ggcttcgttt ctgcgaacta acaggcaagc agcaaagttg tcgaagccaa ccctagaaaa    660

ccttacccca gtggtgctca gaccagagat tcgcaaacca gaggttctca gaccggaaac    720

acccagacca gtggacattg gttctggagg atttggtgat gtcgagcaga aagaccatgg    780

gtttgaggtg gcctccactt cccctgaaga cgagtcccct ggcagtaacc ccgagccaga    840

tgccaccccg ttccaggaag gtttgaggac cttcgaccag ctggacgcca tatctagttt    900

gcccacaccc agtgacatct ttgtgtccta ctctactttc ccaggttttg tttcctggag    960

ggaccccaag agtggctcct ggtacgttga gaccctggac gacatctttg agcagtgggc   1020

tcactctgaa gacctgcagt ccctcctgct tagggtcgct aatgctgttt cggtgaaagg   1080

gatttataaa cagatgcctg gttgctttaa tttcctccgg aaaaaacttt tctttaaaac   1140

atcataaggc cagggcccct caccctgcct tatcttgcac cccaaagctt tcctgcccca   1200

ggcctgaaag aggctgaggc ctggactttc ctgcaactca aggactttgc agccggcaca   1260

gggtctgctc tttctctgcc agtgacagac aggctcttag cagcttccag attgacgaca   1320

agtgctgaac agtggaggaa gagggacaga tgaatgccgt ggattgcacg tggcctcttg   1380

agcagtggct ggtccagggc tagtgacttg tgtcccatga tccctgtgtt gtctctagag   1440

cagggattaa cctctgcact actgacatgt ggggccaggt caccctttgc tgtgaggctg   1500

tcctgtacat tgtgggatgt tcagcactgt cccttgcctc aatgccagta acgcgtcttc   1560

ctgagtggtg ccaaacaaaa aggttctcag gtgttgccaa atatgtcctg gggtataaaa   1620

ctttcctcgc ctgacaacca ctggtctgta gggatttttg gctacacaca aaccagtatc   1680

gctcatagat cagcaaaccg gggcctacta gagtctgaac agctgtaatc tatgaattct   1740

aagtgaaatt ttaaaaattg ttaatttttc ctatattgca ttaattttaa aaaataaatc   1800

tgaggcaaat atggactctc                                               1820


<210>  5402
<211>  266
<212>  PRT
<213>  Homosapiens

<400>  5402

Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Glu Gln Lys Asp His 
    130                 135                 140                 


Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser 
145                 150                 155                 160 


Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe 
                165                 170                 175     


Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe 
            180                 185                 190         


Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys 
        195                 200                 205             


Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp 
    210                 215                 220                 


Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala 
225                 230                 235                 240 


Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe 
                245                 250                 255     


Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
            260                 265     


<210>  5403
<211>  2270
<212>  DNA
<213>  Homosapiens

<400>  5403
gacgcagtgg tggattctgg agcggggcgg tgacgtgggg cgggttctgg ggcggggcgg     60

tgacgcggag cgtgttctgg ggcggcgcgg tgatgggagg cttggccctg ggggcggggc    120

gaggcgcaga ggtgcgtcct gagggcgggg cggtgacgca agagcgactc ctgggggcgg    180

ggcgaggcct tggagatgcg tccggaggcg gtggggagcg aagactgacc cggggccgtg    240

acgcgggggc aggccctggg gcgggggcgg gtcctgggga ctggggcggg cggccgaggc    300

ccggaagcgg actgaggcgg cctggagtct tagttggcta ctcgccatgg acgaagcgga    360

tcggcggctc ctgcggcggt gccggctgcg gctggtggaa gagctgcagg tggaccagct    420

ctgggacgcc ctgctgagcc gcgagctgtt caggccccat atgatcgagg acatccagcg    480

ggcaggctct ggatctcggc gggatcaggc caggcagctg atcatagatc tggagactcg    540

agggagtcag gctcttcctt tgttcatctc ctgcttagag gacacaggcc aggacatgct    600

ggcttcgttt ctgcgaacta acaggcaagc agcaaagttg tcgaagccaa ccctagaaaa    660

ccttacccca gtggtgctca gaccagagat tcgcaaacca gaggttctca gaccggaaac    720

acccagacca gtggacattg gttctggagg atttggtgat gtcggtgctc ttgagagttt    780

gaggggaaat gcagatttgg cttacatcct gagcatggag ccctgtggcc actgcctcat    840

tatcaacaat gtgaacttct gccgtgagtc cgggctccgc acccgcactg gctccaacat    900

cgactgtgag aagttgcggc gtcgcttctc ctcgctgcat ttcatggtgg aggtgaaggg    960

cgacctgact gccaagaaaa tggtgctggc tttgctggag ctggcgcagc aggaccacgg   1020

tgctctggac tgctgcgtgg tggtcattct ctctcacggc tgtcaggcca gccacctgca   1080

gttcccaggg gctgtctacg gcacagatgg atgccctgtg tcggtcgaga agattgtgaa   1140

catcttcaat gggaccagct gccccagcct gggagggaag cccaagctct ttttcatcca   1200

ggcctgtggt ggggagcaga aagaccatgg gtttgaggtg gcctccactt cccctgaaga   1260

cgagtcccct ggcagtaacc ccgagccaga tgccaccccg ttccaggaag gtttgaggac   1320

cttcgaccag ctggacgcca tatctagttt gcccacaccc agtgacatct ttgtgtccta   1380

ctctactttc ccaggttttg tttcctggag ggaccccaag agtggctcct ggtacgttga   1440

gaccctggac gacatctttg agcagtgggc tcactctgaa gacctgcagt ccctcctgct   1500

tagggtcgct aatgctgttt cggtgaaagg gatttataaa cagatgcctg gttgctttaa   1560

tttcctccgg aaaaaacttt tctttaaaac atcataaggc cagggcccct caccctgcct   1620

tatcttgcac cccaaagctt tcctgcccca ggcctgaaag aggctgaggc ctggactttc   1680

ctgcaactca aggactttgc agccggcaca gggtctgctc tttctctgcc agtgacagac   1740

aggctcttag cagcttccag attgacgaca agtgctgaac agtggaggaa gagggacaga   1800

tgaatgccgt ggattgcacg tggcctcttg agcagtggct ggtccagggc tagtgacttg   1860

tgtcccatga tccctgtgtt gtctctagag cagggattaa cctctgcact actgacatgt   1920

ggggccaggt caccctttgc tgtgaggctg tcctgtacat tgtgggatgt tcagcactgt   1980

cccttgcctc aatgccagta acgcgtcttc ctgagtggtg ccaaacaaaa aggttctcag   2040

gtgttgccaa atatgtcctg gggtataaaa ctttcctcgc ctgacaacca ctggtctgta   2100

gggatttttg gctacacaca aaccagtatc gctcatagat cagcaaaccg gggcctacta   2160

gagtctgaac agctgtaatc tatgaattct aagtgaaatt ttaaaaattg ttaatttttc   2220

ctatattgca ttaattttaa aaaataaatc tgaggcaaat atggactctc              2270


<210>  5404
<211>  416
<212>  PRT
<213>  Homosapiens

<400>  5404

Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
    130                 135                 140                 


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
145                 150                 155                 160 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
                165                 170                 175     


Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
            180                 185                 190         


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr 
        195                 200                 205             


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
    210                 215                 220                 


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
225                 230                 235                 240 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys 
                245                 250                 255     


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys 
            260                 265                 270         


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
        275                 280                 285             


Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu 
    290                 295                 300                 


Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln 
305                 310                 315                 320 


Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro 
                325                 330                 335     


Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val 
            340                 345                 350         


Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp 
        355                 360                 365             


Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu 
    370                 375                 380                 


Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met 
385                 390                 395                 400 


Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
                405                 410                 415     


<210>  5405
<211>  425
<212>  DNA
<213>  Homosapiens

<400>  5405
ccacacatgg tccctttttg gcagcacctc tgtctggctg gagcaggccc tgctctgtct     60

gctttgtaga ggtcagagtc ttctgtttca tggcacagtg gcatcatggg ctcaagtaac    120

tttggcagct tcaattccaa agacttggca aaaagaaagc agaagagaga ggagaaacct    180

ctttttattt ttcttgtcac cattctcctg acctccatca actagacccc gtttccacta    240

tcccagagaa agggtggcca cagctaaact gcatggagaa accaaagaat ttaaatattg    300

gaattttcaa aagtgtagtt gtgggggttc gaggaacatt taaagattat tggattcttt    360

gtagttttgc tgtatgctct aattttaaac ttaactccta ttacagtgtt atctgatttt    420

cttat                                                                425


<210>  5406
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  5406

Met Glu Lys Pro Lys Asn Leu Asn Ile Gly Ile Phe Lys Ser Val Val 
1               5                   10                  15      


Val Gly Val Arg Gly Thr Phe Lys Asp Tyr Trp Ile Leu Cys Ser Phe 
            20                  25                  30          


Ala Val Cys Ser Asn Phe Lys Leu Asn Ser Tyr Tyr Ser Val Ile 
        35                  40                  45          


<210>  5407
<211>  2713
<212>  DNA
<213>  Homosapiens

<400>  5407
acctttaagc gtcacgtgac tcccctcggg cttgtcccct cctctttccc ctccccaggc     60

ccaggcgagc gctggtgtgg acgggaagct cccggcccgg cgaactaact ggagcacgga    120

gctgcagccg gttgggccgg tgtactttcc cgctctggaa aggaagagaa atggaagtga    180

gaaagttgag catttcctgg cagttcttga tagttctggt tctgatcctg caaattctgt    240

ctgcgttgga ttttgaccca tacagagtcc taggggtcag ccgaacagcc agtcaggctg    300

atattaaaaa ggcttataag aagctcgccc gggaatggca tcctgacaaa aacaaagatc    360

ctggagcaga agacaagttc attcaaatca gtaaggctta cgagattctt tcaaatgaag    420

aaaagagatc aaattatgat caatatggag acgctggaga gaaccagggc taccagaagc    480

agcaacagca gcgagagtat cgcttccgcc atttccatga aaatttttat tttgatgaat    540

ccttttttca cttccctttt aattctgaac ggcgggactc aattgacgaa aagtatttat    600

tgcacttttc acattatgtg aatgaagtgg ttccagatag cttcaagaaa ccctacctca    660

tcaagatcac ctccgattgg tgctttagct gcattcatat cgagcctgtg tggaaagaag    720

tcattcaaga actggaagaa ttgggtgtag gaattggcgt ggtccatgct gggtatgaga    780

gacgcctggc ccatcaccta ggggcacaca gcacgccctc tatcctagga atcattaacg    840

ggaaaatctc cttcttccac aatgcagttg tccgtgaaaa tctgcgacaa tttgtagaaa    900

gtcttcttcc agggaacttg gtggagaaag ttacaaataa aaattacgtc agattcctct    960

ctggctggca gcaagagaat aagcctcatg tccttctgtt tgaccaaacg cccattgtgc   1020

cactgttata caagttgact gcctttgcat acaaagatta tttatcattt ggatatgtat   1080

atgtgggttt gagagggacg gaagagatga caaggcggta caacatcaat atctacgccc   1140

ctaccctctt ggtctttaaa gaacatataa acaggcctgc cgatgttatc caggcccgag   1200

gtatgaagaa gcaaatcatt gacgacttca tcacccgaaa caaatatcta ttggcagcca   1260

ggctcaccag ccagaagttg ttccatgaac tctgccctgt gaaacggtcg catcgacaga   1320

ggaagtactg tgtggtttta ttgactgctg agactaccaa gttgagcaaa ccctttgagg   1380

ctttcctgtc ctttgccctg gcaaacactc aagacacagt gagatttgtg catgtctaca   1440

gcaatcggca gcaggagttt gccgacacct tactaccaga cagtgaggcg tttcaaggga   1500

aatcagcggt gtctatttta gaaaggcgca acacagcagg aagggtggtg tataaaaccc   1560

tggaagaccc ttggattggg agtgagagtg acaaatttat cctcttgggc tatctcgacc   1620

agctgcgtaa agatccagct cttctgtcct ctgaagcagt gcttcctgac ctgaccgatg   1680

aacttgcccc tgtttttctc cttcgatggt tctactctgc ttctgactac atctcagact   1740

gctgggatag catttttcac aacaactgga gggaaatgat gcccctgctg tccctgatct   1800

tctctgccct cttcatcctc ttcggcactg tcatcgttca ggctttcagc gactctaatg   1860

atgagcgaga gtcaagccct ccagaaaaag aggaagccca agagaagact gggaaaactg   1920

agccaagctt caccaaagaa aacagcagca agattcctaa aaaaggcttt gtggaggtaa   1980

ctgaactcac agatgtaaca tacaccagta acttggtacg tctgaggcca ggccacatga   2040

atgtggtcct catcctgtcg aattctacca agaccagcct actacagaaa tttgctttgg   2100

aggtctacac atttactggg agcagctgcc tacacttctc cttcctgagt ctagataaac   2160

acagagaatg gctagaatac ttactagaat ttgctcaaga tgcagctcca atcccaaacc   2220

aatatgataa gcatttcatg gagcgtgact acactggtta tgtactggct ctgaatggcc   2280

acaagaaata cttctgcctc ttcaagcccc aaaagacagt cgaagaggag gaagccatag   2340

ggtcgtgcag tgatgttgac tcttccctct acctgggtga atctcgaggg aaaccttcct   2400

gtggccttgg atccaggccc atcaaaggaa agttgagcaa gctctcttta tggatggaac   2460

gcctgctgga gggctcctta cagaggtttt atatcccatc atggcctgaa ctagactgag   2520

aggattttcc aaagagattt gaactcttca gactttttaa catgcccctg tgaacaggta   2580

ttttcaggac tcaaactacc acaatgaaca gagtatagat tttagattgc tcttctagaa   2640

ccatggctag aagaatcttt cctttgtcct gttctaacct aggaatgaaa aacaccacca   2700

gtttgaatcg cct                                                      2713


<210>  5408
<211>  782
<212>  PRT
<213>  Homosapiens

<400>  5408

Met Glu Val Arg Lys Leu Ser Ile Ser Trp Gln Phe Leu Ile Val Leu 
1               5                   10                  15      


Val Leu Ile Leu Gln Ile Leu Ser Ala Leu Asp Phe Asp Pro Tyr Arg 
            20                  25                  30          


Val Leu Gly Val Ser Arg Thr Ala Ser Gln Ala Asp Ile Lys Lys Ala 
        35                  40                  45              


Tyr Lys Lys Leu Ala Arg Glu Trp His Pro Asp Lys Asn Lys Asp Pro 
    50                  55                  60                  


Gly Ala Glu Asp Lys Phe Ile Gln Ile Ser Lys Ala Tyr Glu Ile Leu 
65                  70                  75                  80  


Ser Asn Glu Glu Lys Arg Ser Asn Tyr Asp Gln Tyr Gly Asp Ala Gly 
                85                  90                  95      


Glu Asn Gln Gly Tyr Gln Lys Gln Gln Gln Gln Arg Glu Tyr Arg Phe 
            100                 105                 110         


Arg His Phe His Glu Asn Phe Tyr Phe Asp Glu Ser Phe Phe His Phe 
        115                 120                 125             


Pro Phe Asn Ser Glu Arg Arg Asp Ser Ile Asp Glu Lys Tyr Leu Leu 
    130                 135                 140                 


His Phe Ser His Tyr Val Asn Glu Val Val Pro Asp Ser Phe Lys Lys 
145                 150                 155                 160 


Pro Tyr Leu Ile Lys Ile Thr Ser Asp Trp Cys Phe Ser Cys Ile His 
                165                 170                 175     


Ile Glu Pro Val Trp Lys Glu Val Ile Gln Glu Leu Glu Glu Leu Gly 
            180                 185                 190         


Val Gly Ile Gly Val Val His Ala Gly Tyr Glu Arg Arg Leu Ala His 
        195                 200                 205             


His Leu Gly Ala His Ser Thr Pro Ser Ile Leu Gly Ile Ile Asn Gly 
    210                 215                 220                 


Lys Ile Ser Phe Phe His Asn Ala Val Val Arg Glu Asn Leu Arg Gln 
225                 230                 235                 240 


Phe Val Glu Ser Leu Leu Pro Gly Asn Leu Val Glu Lys Val Thr Asn 
                245                 250                 255     


Lys Asn Tyr Val Arg Phe Leu Ser Gly Trp Gln Gln Glu Asn Lys Pro 
            260                 265                 270         


His Val Leu Leu Phe Asp Gln Thr Pro Ile Val Pro Leu Leu Tyr Lys 
        275                 280                 285             


Leu Thr Ala Phe Ala Tyr Lys Asp Tyr Leu Ser Phe Gly Tyr Val Tyr 
    290                 295                 300                 


Val Gly Leu Arg Gly Thr Glu Glu Met Thr Arg Arg Tyr Asn Ile Asn 
305                 310                 315                 320 


Ile Tyr Ala Pro Thr Leu Leu Val Phe Lys Glu His Ile Asn Arg Pro 
                325                 330                 335     


Ala Asp Val Ile Gln Ala Arg Gly Met Lys Lys Gln Ile Ile Asp Asp 
            340                 345                 350         


Phe Ile Thr Arg Asn Lys Tyr Leu Leu Ala Ala Arg Leu Thr Ser Gln 
        355                 360                 365             


Lys Leu Phe His Glu Leu Cys Pro Val Lys Arg Ser His Arg Gln Arg 
    370                 375                 380                 


Lys Tyr Cys Val Val Leu Leu Thr Ala Glu Thr Thr Lys Leu Ser Lys 
385                 390                 395                 400 


Pro Phe Glu Ala Phe Leu Ser Phe Ala Leu Ala Asn Thr Gln Asp Thr 
                405                 410                 415     


Val Arg Phe Val His Val Tyr Ser Asn Arg Gln Gln Glu Phe Ala Asp 
            420                 425                 430         


Thr Leu Leu Pro Asp Ser Glu Ala Phe Gln Gly Lys Ser Ala Val Ser 
        435                 440                 445             


Ile Leu Glu Arg Arg Asn Thr Ala Gly Arg Val Val Tyr Lys Thr Leu 
    450                 455                 460                 


Glu Asp Pro Trp Ile Gly Ser Glu Ser Asp Lys Phe Ile Leu Leu Gly 
465                 470                 475                 480 


Tyr Leu Asp Gln Leu Arg Lys Asp Pro Ala Leu Leu Ser Ser Glu Ala 
                485                 490                 495     


Val Leu Pro Asp Leu Thr Asp Glu Leu Ala Pro Val Phe Leu Leu Arg 
            500                 505                 510         


Trp Phe Tyr Ser Ala Ser Asp Tyr Ile Ser Asp Cys Trp Asp Ser Ile 
        515                 520                 525             


Phe His Asn Asn Trp Arg Glu Met Met Pro Leu Leu Ser Leu Ile Phe 
    530                 535                 540                 


Ser Ala Leu Phe Ile Leu Phe Gly Thr Val Ile Val Gln Ala Phe Ser 
545                 550                 555                 560 


Asp Ser Asn Asp Glu Arg Glu Ser Ser Pro Pro Glu Lys Glu Glu Ala 
                565                 570                 575     


Gln Glu Lys Thr Gly Lys Thr Glu Pro Ser Phe Thr Lys Glu Asn Ser 
            580                 585                 590         


Ser Lys Ile Pro Lys Lys Gly Phe Val Glu Val Thr Glu Leu Thr Asp 
        595                 600                 605             


Val Thr Tyr Thr Ser Asn Leu Val Arg Leu Arg Pro Gly His Met Asn 
    610                 615                 620                 


Val Val Leu Ile Leu Ser Asn Ser Thr Lys Thr Ser Leu Leu Gln Lys 
625                 630                 635                 640 


Phe Ala Leu Glu Val Tyr Thr Phe Thr Gly Ser Ser Cys Leu His Phe 
                645                 650                 655     


Ser Phe Leu Ser Leu Asp Lys His Arg Glu Trp Leu Glu Tyr Leu Leu 
            660                 665                 670         


Glu Phe Ala Gln Asp Ala Ala Pro Ile Pro Asn Gln Tyr Asp Lys His 
        675                 680                 685             


Phe Met Glu Arg Asp Tyr Thr Gly Tyr Val Leu Ala Leu Asn Gly His 
    690                 695                 700                 


Lys Lys Tyr Phe Cys Leu Phe Lys Pro Gln Lys Thr Val Glu Glu Glu 
705                 710                 715                 720 


Glu Ala Ile Gly Ser Cys Ser Asp Val Asp Ser Ser Leu Tyr Leu Gly 
                725                 730                 735     


Glu Ser Arg Gly Lys Pro Ser Cys Gly Leu Gly Ser Arg Pro Ile Lys 
            740                 745                 750         


Gly Lys Leu Ser Lys Leu Ser Leu Trp Met Glu Arg Leu Leu Glu Gly 
        755                 760                 765             


Ser Leu Gln Arg Phe Tyr Ile Pro Ser Trp Pro Glu Leu Asp 
    770                 775                 780         


<210>  5409
<211>  6305
<212>  DNA
<213>  Homosapiens

<400>  5409
acctttaagc gtcacgtgac tcccctcggg cttgtcccct cctctttccc ctccccaggc     60

ccaggcgagc gctggtgtgg acgggaagct cccggcccgg cgaactaact ggagcacgga    120

gctgcagccg gttgggccgg tgtactttcc cgctctggaa aggaagagaa atggaagtga    180

gaaagttgag catttcctgg cagttcttga tagttctggt tctgatcctg caaattctgt    240

ctgcgttgga ttttgaccca tacagagtcc taggggtcag ccgaacagcc agtcaggctg    300

atattaaaaa ggcttataag aagctcgccc gggaatggca tcctgacaaa aacaaagatc    360

ctggagcaga agacaagttc attcaaatca gtaaggctta cgagattctt tcaaatgaag    420

aaaagagatc aaattatgat caatatggag acgctggaga gaaccagggc taccagaagc    480

agcaacagca gcgagagtat cgcttccgcc atttccatga aaatttttat tttgatgaat    540

ccttttttca cttccctttt aattctgaac ggcgggactc aattgacgaa aagtatttat    600

tgcacttttc acattatgtg aatgaagtgg ttccagatag cttcaagaaa ccctacctca    660

tcaagatcac ctccgattgg tgctttagct gcattcatat cgagcctgtg tggaaagaag    720

tcattcaaga actggaagaa ttgggtgtag gaattggcgt ggtccatgct gggtatgaga    780

gacgcctggc ccatcaccta ggggcacaca gcacgccctc tatcctagga atcattaacg    840

ggaaaatctc cttcttccac aatgcagttg tccgtgaaaa tctgcgacaa tttgtagaaa    900

gtcttcttcc agggaacttg gtggagaaag ttacaaataa aaattacgtc agattcctct    960

ctggctggca gcaagagaat aagcctcatg tccttctgtt tgaccaaacg cccattgtgc   1020

cactgttata caagttgact gcctttgcat acaaagatta tttatcattt ggatatgtat   1080

atgtgggttt gagagggacg gaagagatga caaggcggta caacatcaat atctacgccc   1140

ctaccctctt ggtctttaaa gaacatataa acaggcctgc cgatgttatc caggcccgag   1200

gtatgaagaa gcaaatcatt gacgacttca tcacccgaaa caaatatcta ttggcagcca   1260

ggctcaccag ccagaagttg ttccatgaac tctgccctgt gaaacggtcg catcgacaga   1320

ggaagtactg tgtggtttta ttgactgctg agactaccaa gttgagcaaa ccctttgagg   1380

ctttcctgtc ctttgccctg gcaaacactc aagacacagt gagatttgtg catgtctaca   1440

gcaatcggca gcaggagttt gccgacacct tactaccaga cagtgaggcg tttcaaggga   1500

aatcagcggt gtctatttta gaaaggcgca acacagcagg aagggtggtg tataaaaccc   1560

tggaagaccc ttggattggg agtgagagtg acaaatttat cctcttgggc tatctcgacc   1620

agctgcgtaa agatccagct cttctgtcct ctgaagcagt gcttcctgac ctgaccgatg   1680

aacttgcccc tgtttttctc cttcgatggt tctactctgc ttctgactac atctcagact   1740

gctgggatag catttttcac aacaactgga gggaaatgat gcccctgctg tccctgatct   1800

tctctgccct cttcatcctc ttcggcactg tcatcgttca ggctttcagc gactctaatg   1860

atgagcgaga gtcaagccct ccagaaaaag aggaagccca agagaagact gggaaaactg   1920

agccaagctt caccaaagaa aacagcaggt ttctctaaca aaacaccaga ctcacctccc   1980

cggcacctgc cccccagatc ctgtcatctg ataacgcagc attggaacat agagtgtaga   2040

gaagaactct catgcacctc ctcccatgta aactgtggct acagggaaaa gtcactgtga   2100

tttgtgttta ctaagaccct gtaggtgttt agatgcctta gatttcataa tgaaggcaga   2160

aggaaagaag cctatcaggc aagtattcct aaaaaaggct ttgtggaggt aactgaactc   2220

acagatgtaa catacaccag taacttggta cgtctgaggc caggccacat gaatgtggtc   2280

ctcatcctgt cgaattctac caagaccagc ctactacaga aatttgcttt ggaggtctac   2340

acatttactg ggagcagctg cctacacttc tccttcctga gtctagataa acacagagaa   2400

tggctagaat acttactaga atttgctcaa gatgcagctc caatcccaaa ccaatatgat   2460

aagcatttca tggagcgtga ctacactggt tatgtactgg ctctgaatgg ccacaagaaa   2520

tacttctgcc tcttcaagcc ccaaaagaca gtcgaagagg aggaagccat agggtcgtgc   2580

agtgatgttg actcttccct ctacctgggt gaatctcgag ggaaaccttc ctgtggcctt   2640

ggatccaggc ccatcaaagg aaagttgagc aagctctctt tatggatgga acgcctgctg   2700

gagggctcct tacagaggtt ttatatccca tcatggcctg aactagactg agaggatttt   2760

ccaaagagat ttgaactctt cagacttttt aacatgcccc tgtgaacagg tattttcagg   2820

actcaaacta ccacaatgaa cagagtatag attttagatt gctcttctag aaccatggct   2880

agaagaatct ttcctttgtc ctgttctaac ctaggaatga aaaacaccac cagtttgaat   2940

cgcctagatg aaaatctttt cctctgggtg ttatttttcc ccactgaatg ccacaccatt   3000

gaaaatagac tgctcatccc ctcttccttt cttgtccttg tcccatgctc accccaccct   3060

cctgtcctgt gtcttggaga agcacagggc tccaccctgc aagcggcatc tggcggaccc   3120

tcatgagcct gtcgtgcagg ccaggtcatt ggccccttcc ccaatcccgg ccctgctgtg   3180

ctgctgccat ggcgcatgct cctaactctg aacaacccac ggcagcttct agccccgcat   3240

ctggaaaaag gcccctttcc aagcaatctc acgtttactg gttgttctgg gagtaagtgg   3300

ctaaatgtat attttggggg tatcccccaa caacagtttg ttggccacag gttgaaaagg   3360

aaaggaataa acgggagttc tgcatgtgag ttctcaagaa aaggaaaggg aggctgagca   3420

gtggctgaag cgatgcagcc ttgagacacg ctgtgagcat cccatccgcc gccccagcgc   3480

tgctggtagc caggggaggg gtctgcacag cgagaagtac tgtgatgact ttgagccgtt   3540

gacatgtatg tcttcagatg cctttctgcc tctgtcgatt ttagggtatg gatattagga   3600

gccataactt gtaatcttgt tctctgaacg tagagataag ctgctataaa gccagtagat   3660

gttaaactga agagaaatta ttcccacctg ctatgagtca ggcttaagga atctcttcaa   3720

tagtgtctct ttagtaaaat accaaacatg tctttgtatc aaggaactta aaatttctca   3780

acaattgtat tttgaacact gttaccctaa aagtgctgtc tcttcaagtc atcttttgca   3840

ggaagtgagc caagatttgt tctagactcc cattttgcaa aaggcttact ttccacttct   3900

gggctgtatt ttgatgtctc atcttcattg ttttcactct taacttagag ctgcttcacc   3960

agtattgggg tcagactggc catcagcacc tgagcgtgct gagctccagg tatagtggac   4020

cccagggtgc ctcataccag ccagttagag agcatacctt ttatttttca gggcagaatg   4080

accagtggtt ctgagtttga gtttggacag cttcaaagag tggtccgttc aaatgtcaaa   4140

gcaaggtgcc tttggtggct ttgtgaaggg tgaaaatcag tgatgggaca tttactaagt   4200

atttcttttt tttttttttt ttttagttgt tgagacagag tttcactctt gttgcccagg   4260

ctggagtgaa atggtgcgat ctcggttcac cgcaacctcc acatcccagg ttcaagtgat   4320

tctcctgcct cagcctcctg agtagctagg attacaggca tgtgccacca tgtaattagc   4380

ccggctaatt ttgtattttt agtagagacg ggatttctcc atgttgatca ggctggtcat   4440

gaactcctga cctcaggtga tctgcctgcc tcagcctccc aaagtgctgc tgggattaca   4500

ggcgtgagcc accactcccg gctaagttag tatttcttta atcttaatgc tttaaactaa   4560

gccacttgga tcctgaataa tttaaatctt gagctacatt ggtaagtaat aaattattta   4620

aggccaggaa ttcctgtagt tttcatggag tctgtagctt tattaaaaaa taaatcactg   4680

ccaggcttca ttcttccata tgatcctcta aaaatggaca cttcctctga atgctgtatc   4740

tcatggcacc tggtccaact agaaatggtc aaggaattca tttggctcct tgatacatca   4800

gtcctcaata ttactttcta ggtattttat ggccagattg cttatatgag tggtcttttg   4860

gtttggtagt aggtttttat ttttaatttc tgtactaatg aaattcctga ctttaatttc   4920

tgaaaaccaa aaactctcca agtgtattta tttatatttt ttttaataga gacgaggtct   4980

tgctatgttg cccaggctgg tcccaaactc ctggcctcaa gcagtccttc caccttggcc   5040

tcccaaagtg ctgggattat caatatgagc caccatgcca gatttgttca tttttaaaca   5100

tttttatctc ttcaagtcat cttttgatct tttaaaaagc accttcaaac agctgcacct   5160

tccatttgca ctaggaaatg aaggtagtga tgggattggc aatgttcctg gcagatgttt   5220

cagcccaaaa gctcttctac agaccggttt agagctggtg ccctatgaga atattaggga   5280

gcttttattt taaattgaac tttacccttg tccatgcaag gcattcctcc tgaatgcatc   5340

catgaatttg tttacttttg cgtcaaacat atgagccatt gtcatgctca gcctgtgcca   5400

ccattgctct gtctgatgta tgtaatcata caagacctga ttttggttct aacacagtgg   5460

tctttgacta tcaacattga tgtttttaga gatgggttct tctggttgat acagactatg   5520

cattgcgttt agcagatggg gtaaaactgg cctaaaacaa gtctttgcag aatacatgcc   5580

aatttccaaa aaaaaaaaaa aatttgttgc tcaggtgttg cacaattttt atctaacact   5640

gaggctatca gctccaacta aacaacattt cagtgggtga ggctgcccta acttccatta   5700

ggggccatgg tctcactgcc atcacttatt agccatgaga atttggttgt agttttcagg   5760

taggttggtt tcttcctcat ttgcagcttg ttgatacttg ttccttttta tttattaaca   5820

tcccaatcaa tttgcagctg ccatcattac ataaatattt ttctgttata aaaagaagtg   5880

tgatctgttt ttttagtgat ttcctttgtt tgggaataga gattggaagc acatactcag   5940

acctgttttg ttaactagaa ttctttaaaa gctgatgcca aacatcttta cagaggaact   6000

gtagttcaca tccacctgtc tgacattgtc ccctaaaaac aagtgcagtg tggcagctgc   6060

tgaatctgtc tgttcagttt gtcaaggagg ataattatgc ttgggagaga tctgaaaaga   6120

aggtgaatat tttgcacttt tgatactctt aggaacaaat aacttatttg gcaaattgtt   6180

tcttttttat gttttgggtg ttgtttttgt tttttgactt tttttgtatt gtgaacaggc   6240

actgaagctg atgttatttt aagattacag aatggaaaaa gaaataaact attttaatgt   6300

ctgat                                                               6305


<210>  5410
<211>  595
<212>  PRT
<213>  Homosapiens

<400>  5410

Met Glu Val Arg Lys Leu Ser Ile Ser Trp Gln Phe Leu Ile Val Leu 
1               5                   10                  15      


Val Leu Ile Leu Gln Ile Leu Ser Ala Leu Asp Phe Asp Pro Tyr Arg 
            20                  25                  30          


Val Leu Gly Val Ser Arg Thr Ala Ser Gln Ala Asp Ile Lys Lys Ala 
        35                  40                  45              


Tyr Lys Lys Leu Ala Arg Glu Trp His Pro Asp Lys Asn Lys Asp Pro 
    50                  55                  60                  


Gly Ala Glu Asp Lys Phe Ile Gln Ile Ser Lys Ala Tyr Glu Ile Leu 
65                  70                  75                  80  


Ser Asn Glu Glu Lys Arg Ser Asn Tyr Asp Gln Tyr Gly Asp Ala Gly 
                85                  90                  95      


Glu Asn Gln Gly Tyr Gln Lys Gln Gln Gln Gln Arg Glu Tyr Arg Phe 
            100                 105                 110         


Arg His Phe His Glu Asn Phe Tyr Phe Asp Glu Ser Phe Phe His Phe 
        115                 120                 125             


Pro Phe Asn Ser Glu Arg Arg Asp Ser Ile Asp Glu Lys Tyr Leu Leu 
    130                 135                 140                 


His Phe Ser His Tyr Val Asn Glu Val Val Pro Asp Ser Phe Lys Lys 
145                 150                 155                 160 


Pro Tyr Leu Ile Lys Ile Thr Ser Asp Trp Cys Phe Ser Cys Ile His 
                165                 170                 175     


Ile Glu Pro Val Trp Lys Glu Val Ile Gln Glu Leu Glu Glu Leu Gly 
            180                 185                 190         


Val Gly Ile Gly Val Val His Ala Gly Tyr Glu Arg Arg Leu Ala His 
        195                 200                 205             


His Leu Gly Ala His Ser Thr Pro Ser Ile Leu Gly Ile Ile Asn Gly 
    210                 215                 220                 


Lys Ile Ser Phe Phe His Asn Ala Val Val Arg Glu Asn Leu Arg Gln 
225                 230                 235                 240 


Phe Val Glu Ser Leu Leu Pro Gly Asn Leu Val Glu Lys Val Thr Asn 
                245                 250                 255     


Lys Asn Tyr Val Arg Phe Leu Ser Gly Trp Gln Gln Glu Asn Lys Pro 
            260                 265                 270         


His Val Leu Leu Phe Asp Gln Thr Pro Ile Val Pro Leu Leu Tyr Lys 
        275                 280                 285             


Leu Thr Ala Phe Ala Tyr Lys Asp Tyr Leu Ser Phe Gly Tyr Val Tyr 
    290                 295                 300                 


Val Gly Leu Arg Gly Thr Glu Glu Met Thr Arg Arg Tyr Asn Ile Asn 
305                 310                 315                 320 


Ile Tyr Ala Pro Thr Leu Leu Val Phe Lys Glu His Ile Asn Arg Pro 
                325                 330                 335     


Ala Asp Val Ile Gln Ala Arg Gly Met Lys Lys Gln Ile Ile Asp Asp 
            340                 345                 350         


Phe Ile Thr Arg Asn Lys Tyr Leu Leu Ala Ala Arg Leu Thr Ser Gln 
        355                 360                 365             


Lys Leu Phe His Glu Leu Cys Pro Val Lys Arg Ser His Arg Gln Arg 
    370                 375                 380                 


Lys Tyr Cys Val Val Leu Leu Thr Ala Glu Thr Thr Lys Leu Ser Lys 
385                 390                 395                 400 


Pro Phe Glu Ala Phe Leu Ser Phe Ala Leu Ala Asn Thr Gln Asp Thr 
                405                 410                 415     


Val Arg Phe Val His Val Tyr Ser Asn Arg Gln Gln Glu Phe Ala Asp 
            420                 425                 430         


Thr Leu Leu Pro Asp Ser Glu Ala Phe Gln Gly Lys Ser Ala Val Ser 
        435                 440                 445             


Ile Leu Glu Arg Arg Asn Thr Ala Gly Arg Val Val Tyr Lys Thr Leu 
    450                 455                 460                 


Glu Asp Pro Trp Ile Gly Ser Glu Ser Asp Lys Phe Ile Leu Leu Gly 
465                 470                 475                 480 


Tyr Leu Asp Gln Leu Arg Lys Asp Pro Ala Leu Leu Ser Ser Glu Ala 
                485                 490                 495     


Val Leu Pro Asp Leu Thr Asp Glu Leu Ala Pro Val Phe Leu Leu Arg 
            500                 505                 510         


Trp Phe Tyr Ser Ala Ser Asp Tyr Ile Ser Asp Cys Trp Asp Ser Ile 
        515                 520                 525             


Phe His Asn Asn Trp Arg Glu Met Met Pro Leu Leu Ser Leu Ile Phe 
    530                 535                 540                 


Ser Ala Leu Phe Ile Leu Phe Gly Thr Val Ile Val Gln Ala Phe Ser 
545                 550                 555                 560 


Asp Ser Asn Asp Glu Arg Glu Ser Ser Pro Pro Glu Lys Glu Glu Ala 
                565                 570                 575     


Gln Glu Lys Thr Gly Lys Thr Glu Pro Ser Phe Thr Lys Glu Asn Ser 
            580                 585                 590         


Arg Phe Leu 
        595 


<210>  5411
<211>  3598
<212>  DNA
<213>  Homosapiens

<400>  5411
acctttaagc gtcacgtgac tcccctcggg cttgtcccct cctctttccc ctccccaggc     60

ccaggcgagc gctggtgtgg acgggaagct cccggcccgg cgaactaact ggagcacgga    120

gctgcagccg gttgggccgg tgtactttcc cgctctggaa aggaagagaa atggaagtga    180

gaaagttgag catttcctgg cagttcttga tagttctggt tctgatcctg caaattctgt    240

ctgcgttgga ttttgaccca tacagagtcc taggggtcag ccgaacagcc agtcaggctg    300

atattaaaaa ggcttataag aagctcgccc gggaatggca tcctgacaaa aacaaagatc    360

ctggagcaga agacaagttc attcaaatca gtaaggctta cgagattctt tcaaatgaag    420

aaaagagatc aaattatgat caatatggag acgctggaga gaaccagggc taccagaagc    480

agcaacagca gcgagagtat cgcttccgcc atttccatga aaatttttat tttgatgaat    540

ccttttttca cttccctttt aattctgaac ggcgggactc aattgacgaa aagtatttat    600

tgcacttttc acattatgtg aatgaagtgg ttccagatag cttcaagaaa ccctacctca    660

tcaagatcac ctccgattgg tgctttagct gcattcatat cgagcctgtg tggaaagaag    720

tcattcaaga actggaagaa ttgggtgtag gaattggcgt ggtccatgct gggtatgaga    780

gacgcctggc ccatcaccta ggggcacaca gcacgccctc tatcctagga atcattaacg    840

ggaaaatctc cttcttccac aatgcagttg tccgtgaaaa tctgcgacaa tttgtagaaa    900

gtcttcttcc agggaacttg gtggagaaag ttacaaataa aaattacgtc agattcctct    960

ctggctggca gcaagagaat aagcctcatg tccttctgtt tgaccaaacg cccattgtgc   1020

cactgttata caagttgact gcctttgcat acaaagatta tttatcattt ggatatgtat   1080

atgtgggttt gagagggacg gaagagatga caaggcggta caacatcaat atctacgccc   1140

ctaccctctt ggtctttaaa gaacatataa acaggcctgc cgatgttatc caggcccgag   1200

gtatgaagaa gcaaatcatt gacgacttca tcacccgaaa caaatatcta ttggcagcca   1260

ggctcaccag ccagaagttg ttccatgaac tctgccctgt gaaacggtcg catcgacaga   1320

ggaagtactg tgtggtttta ttgactgctg agactaccaa gttgagcaaa ccctttgagg   1380

ctttcctgtc ctttgccctg gcaaacactc aagacacagt gagatttgtg catgtctaca   1440

gcaatcggca gcaggagttt gccgacacct tactaccaga cagtgaggcg tttcaaggga   1500

aatcagcggt gtctatttta gaaaggcgca acacagcagg aagggtggtg tataaaaccc   1560

tggaagaccc ttggattggg agtgagagtg acaaatttat cctcttgggc tatctcgacc   1620

agctgcgtaa agatccagct cttctgtcct ctgaagcagt gcttcctgac ctgaccgatg   1680

aacttgcccc tgtttttctc cttcgatggt tctactctgc ttctgactac atctcagact   1740

gctgggatag catttttcac aacaactgga gggaaatgat gcccctgctg tccctgatct   1800

tctctgccct cttcatcctc ttcggcactg tcatcgttca ggctttcagc gactctaatg   1860

atgagcgaga gtcaagccct ccagaaaaag aggaagccca agagaagact gggaaaactg   1920

agccaagctt caccaaagaa aacagcaggt ttctctaaca aaacaccaga ctcacctccc   1980

cggcacctgc cccccagatc ctgtcatctg ataacgcagc attggaacat agagtgtaga   2040

gaagaactct catgcacctc ctcccatgta aactgtggct acagggaaaa gtcactgtga   2100

tttgtgttta ctaagaccct gtaggtgttt agatgcctta gatttcataa tgaaggcaga   2160

aggaaagaag cctatcaggc aagtgttagg tgagccagaa gcaggacgtg gtttatccct   2220

gtaaatgtca atgaacgtaa ccagtcttgt gcgcacacac acccagcagc aagaggccag   2280

ggtctccgag acaaagaaca tagactgaat gatagttgtc ttcttcattc tgtcctagag   2340

caacttctgc acctgaaaag caccaccatg ccagatttgt tcatttttaa acatttttat   2400

ctcttcaagt catcttttga tcttttaaaa agcaccttca aacagctgca ccttccattt   2460

gcactaggaa atgaaggtag tgatgggatt ggcaatgttc ctggcagatg tttcagccca   2520

aaagctcttc tacagaccgg tttagagctg gtgccctatg agaatattag ggagctttta   2580

ttttaaattg aactttaccc ttgtccatgc aaggcattcc tcctgaatgc atccatgaat   2640

ttgtttactt ttgcgtcaaa catatgagcc attgtcatgc tcagcctgtg ccaccattgc   2700

tctgtctgat gtatgtaatc atacaagacc tgattttggt tctaacacag tggtctttga   2760

ctatcaacat tgatgttttt agagatgggt tcttctggtt gatacagact atgcattgcg   2820

tttagcagat ggggtaaaac tggcctaaaa caagtctttg cagaatacat gccaatttcc   2880

aaaaaaaaaa aaaaatttgt tgctcaggtg ttgcacaatt tttatctaac actgaggcta   2940

tcagctccaa ctaaacaaca tttcagtggg tgaggctgcc ctaacttcca ttaggggcca   3000

tggtctcact gccatcactt attagccatg agaatttggt tgtagttttc aggtaggttg   3060

gtttcttcct catttgcagc ttgttgatac ttgttccttt ttatttatta acatcccaat   3120

caatttgcag ctgccatcat tacataaata tttttctgtt ataaaaagaa gtgtgatctg   3180

tttttttagt gatttccttt gtttgggaat agagattgga agcacatact cagacctgtt   3240

ttgttaacta gaattcttta aaagctgatg ccaaacatct ttacagagga actgtagttc   3300

acatccacct gtctgacatt gtcccctaaa aacaagtgca gtgtggcagc tgctgaatct   3360

gtctgttcag tttgtcaagg aggataatta tgcttgggag agatctgaaa agaaggtgaa   3420

tattttgcac ttttgatact cttaggaaca aataacttat ttggcaaatt gtttcttttt   3480

tatgttttgg gtgttgtttt tgttttttga ctttttttgt attgtgaaca ggcactgaag   3540

ctgatgttat tttaagatta cagaatggaa aaagaaataa actattttaa tgtctgat     3598


<210>  5412
<211>  595
<212>  PRT
<213>  Homosapiens

<400>  5412

Met Glu Val Arg Lys Leu Ser Ile Ser Trp Gln Phe Leu Ile Val Leu 
1               5                   10                  15      


Val Leu Ile Leu Gln Ile Leu Ser Ala Leu Asp Phe Asp Pro Tyr Arg 
            20                  25                  30          


Val Leu Gly Val Ser Arg Thr Ala Ser Gln Ala Asp Ile Lys Lys Ala 
        35                  40                  45              


Tyr Lys Lys Leu Ala Arg Glu Trp His Pro Asp Lys Asn Lys Asp Pro 
    50                  55                  60                  


Gly Ala Glu Asp Lys Phe Ile Gln Ile Ser Lys Ala Tyr Glu Ile Leu 
65                  70                  75                  80  


Ser Asn Glu Glu Lys Arg Ser Asn Tyr Asp Gln Tyr Gly Asp Ala Gly 
                85                  90                  95      


Glu Asn Gln Gly Tyr Gln Lys Gln Gln Gln Gln Arg Glu Tyr Arg Phe 
            100                 105                 110         


Arg His Phe His Glu Asn Phe Tyr Phe Asp Glu Ser Phe Phe His Phe 
        115                 120                 125             


Pro Phe Asn Ser Glu Arg Arg Asp Ser Ile Asp Glu Lys Tyr Leu Leu 
    130                 135                 140                 


His Phe Ser His Tyr Val Asn Glu Val Val Pro Asp Ser Phe Lys Lys 
145                 150                 155                 160 


Pro Tyr Leu Ile Lys Ile Thr Ser Asp Trp Cys Phe Ser Cys Ile His 
                165                 170                 175     


Ile Glu Pro Val Trp Lys Glu Val Ile Gln Glu Leu Glu Glu Leu Gly 
            180                 185                 190         


Val Gly Ile Gly Val Val His Ala Gly Tyr Glu Arg Arg Leu Ala His 
        195                 200                 205             


His Leu Gly Ala His Ser Thr Pro Ser Ile Leu Gly Ile Ile Asn Gly 
    210                 215                 220                 


Lys Ile Ser Phe Phe His Asn Ala Val Val Arg Glu Asn Leu Arg Gln 
225                 230                 235                 240 


Phe Val Glu Ser Leu Leu Pro Gly Asn Leu Val Glu Lys Val Thr Asn 
                245                 250                 255     


Lys Asn Tyr Val Arg Phe Leu Ser Gly Trp Gln Gln Glu Asn Lys Pro 
            260                 265                 270         


His Val Leu Leu Phe Asp Gln Thr Pro Ile Val Pro Leu Leu Tyr Lys 
        275                 280                 285             


Leu Thr Ala Phe Ala Tyr Lys Asp Tyr Leu Ser Phe Gly Tyr Val Tyr 
    290                 295                 300                 


Val Gly Leu Arg Gly Thr Glu Glu Met Thr Arg Arg Tyr Asn Ile Asn 
305                 310                 315                 320 


Ile Tyr Ala Pro Thr Leu Leu Val Phe Lys Glu His Ile Asn Arg Pro 
                325                 330                 335     


Ala Asp Val Ile Gln Ala Arg Gly Met Lys Lys Gln Ile Ile Asp Asp 
            340                 345                 350         


Phe Ile Thr Arg Asn Lys Tyr Leu Leu Ala Ala Arg Leu Thr Ser Gln 
        355                 360                 365             


Lys Leu Phe His Glu Leu Cys Pro Val Lys Arg Ser His Arg Gln Arg 
    370                 375                 380                 


Lys Tyr Cys Val Val Leu Leu Thr Ala Glu Thr Thr Lys Leu Ser Lys 
385                 390                 395                 400 


Pro Phe Glu Ala Phe Leu Ser Phe Ala Leu Ala Asn Thr Gln Asp Thr 
                405                 410                 415     


Val Arg Phe Val His Val Tyr Ser Asn Arg Gln Gln Glu Phe Ala Asp 
            420                 425                 430         


Thr Leu Leu Pro Asp Ser Glu Ala Phe Gln Gly Lys Ser Ala Val Ser 
        435                 440                 445             


Ile Leu Glu Arg Arg Asn Thr Ala Gly Arg Val Val Tyr Lys Thr Leu 
    450                 455                 460                 


Glu Asp Pro Trp Ile Gly Ser Glu Ser Asp Lys Phe Ile Leu Leu Gly 
465                 470                 475                 480 


Tyr Leu Asp Gln Leu Arg Lys Asp Pro Ala Leu Leu Ser Ser Glu Ala 
                485                 490                 495     


Val Leu Pro Asp Leu Thr Asp Glu Leu Ala Pro Val Phe Leu Leu Arg 
            500                 505                 510         


Trp Phe Tyr Ser Ala Ser Asp Tyr Ile Ser Asp Cys Trp Asp Ser Ile 
        515                 520                 525             


Phe His Asn Asn Trp Arg Glu Met Met Pro Leu Leu Ser Leu Ile Phe 
    530                 535                 540                 


Ser Ala Leu Phe Ile Leu Phe Gly Thr Val Ile Val Gln Ala Phe Ser 
545                 550                 555                 560 


Asp Ser Asn Asp Glu Arg Glu Ser Ser Pro Pro Glu Lys Glu Glu Ala 
                565                 570                 575     


Gln Glu Lys Thr Gly Lys Thr Glu Pro Ser Phe Thr Lys Glu Asn Ser 
            580                 585                 590         


Arg Phe Leu 
        595 


<210>  5413
<211>  6073
<212>  DNA
<213>  Homosapiens

<400>  5413
acctttaagc gtcacgtgac tcccctcggg cttgtcccct cctctttccc ctccccaggc     60

ccaggcgagc gctggtgtgg acgggaagct cccggcccgg cgaactaact ggagcacgga    120

gctgcagccg gttgggccgg tgtactttcc cgctctggaa aggaagagaa atggaagtga    180

gaaagttgag catttcctgg cagttcttga tagttctggt tctgatcctg caaattctgt    240

ctgcgttgga ttttgaccca tacagagtcc taggggtcag ccgaacagcc agtcaggctg    300

atattaaaaa ggcttataag aagctcgccc gggaatggca tcctgacaaa aacaaagatc    360

ctggagcaga agacaagttc attcaaatca gtaaggctta cgagattctt tcaaatgaag    420

aaaagagatc aaattatgat caatatggag acgctggaga gaaccagggc taccagaagc    480

agcaacagca gcgagagtat cgcttccgcc atttccatga aaatttttat tttgatgaat    540

ccttttttca cttccctttt aattctgaac ggcgggactc aattgacgaa aagtatttat    600

tgcacttttc acattatgtg aatgaagtgg ttccagatag cttcaagaaa ccctacctca    660

tcaagatcac ctccgattgg tgctttagct gcattcatat cgagcctgtg tggaaagaag    720

tcattcaaga actggaagaa ttgggtgtag gaattggcgt ggtccatgct gggtatgaga    780

gacgcctggc ccatcaccta ggggcacaca gcacgccctc tatcctagga atcattaacg    840

ggaaaatctc cttcttccac aatgcagttg tccgtgaaaa tctgcgacaa tttgtagaaa    900

gtcttcttcc agggaacttg gtggagaaag ttacaaataa aaattacgtc agattcctct    960

ctggctggca gcaagagaat aagcctcatg tccttctgtt tgaccaaacg cccattgtgc   1020

cactgttata caagttgact gcctttgcat acaaagatta tttatcattt ggatatgtat   1080

atgtgggttt gagagggacg gaagagatga caaggcggta caacatcaat atctacgccc   1140

ctaccctctt ggtctttaaa gaacatataa acaggcctgc cgatgttatc caggcccgag   1200

gtatgaagaa gcaaatcatt gacgacttca tcacccgaaa caaatatcta ttggcagcca   1260

ggctcaccag ccagaagttg ttccatgaac tctgccctgt gaaacggtcg catcgacaga   1320

ggaagtactg tgtggtttta ttgactgctg agactaccaa gttgagcaaa ccctttgagg   1380

ctttcctgtc ctttgccctg gcaaacactc aagacacagt gagatttgtg catgtctaca   1440

gcaatcggca gcaggagttt gccgacacct tactaccaga cagtgaggcg tttcaaggga   1500

aatcagcggt gtctatttta gaaaggcgca acacagcagg aagggtggtg tataaaaccc   1560

tggaagaccc ttggattggg agtgagagtg acaaatttat cctcttgggc tatctcgacc   1620

agctgcgtaa agatccagct cttctgtcct ctgaagcagt gcttcctgac ctgaccgatg   1680

aacttgcccc tgtttttctc cttcgatggt tctactctgc ttctgactac atctcagact   1740

gctgggatag catttttcac aacaactgga gggaaatgat gcccctgctg tccctgatct   1800

tctctgccct cttcatcctc ttcggcactg tcatcgttca ggctttcagc gactctaatg   1860

atgagcgaga gtcaagccct ccagaaaaag aggaagccca agagaagact gggaaaactg   1920

agccaagctt caccaaagaa aacagcagca agattcctaa aaaaggcttt gtggaggtaa   1980

ctgaactcac agatgtaaca tacaccagta acttggtacg tctgaggcca ggccacatga   2040

atgtggtcct catcctgtcg aattctacca agaccagcct actacagaaa tttgctttgg   2100

aggtctacac atttactggg agcagctgcc tacacttctc cttcctgagt ctagataaac   2160

acagagaatg gctagaatac ttactagaat ttgctcaaga tgcagctcca atcccaaacc   2220

aatatgataa gcatttcatg gagcgtgact acactggtta tgtactggct ctgaatggcc   2280

acaagaaata cttctgcctc ttcaagcccc aaaagacagt cgaagaggag gaagccatag   2340

ggtcgtgcag tgatgttgac tcttccctct acctgggtga atctcgaggg aaaccttcct   2400

gtggccttgg atccaggccc atcaaaggaa agttgagcaa gctctcttta tggatggaac   2460

gcctgctgga gggctcctta cagaggtttt atatcccatc atggcctgaa ctagactgag   2520

aggattttcc aaagagattt gaactcttca gactttttaa catgcccctg tgaacaggta   2580

ttttcaggac tcaaactacc acaatgaaca gagtatagat tttagattgc tcttctagaa   2640

ccatggctag aagaatcttt cctttgtcct gttctaacct aggaatgaaa aacaccacca   2700

gtttgaatcg cctagatgaa aatcttttcc tctgggtgtt atttttcccc actgaatgcc   2760

acaccattga aaatagactg ctcatcccct cttcctttct tgtccttgtc ccatgctcac   2820

cccaccctcc tgtcctgtgt cttggagaag cacagggctc caccctgcaa gcggcatctg   2880

gcggaccctc atgagcctgt cgtgcaggcc aggtcattgg ccccttcccc aatcccggcc   2940

ctgctgtgct gctgccatgg cgcatgctcc taactctgaa caacccacgg cagcttctag   3000

ccccgcatct ggaaaaaggc ccctttccaa gcaatctcac gtttactggt tgttctggga   3060

gtaagtggct aaatgtatat tttgggggta tcccccaaca acagtttgtt ggccacaggt   3120

tgaaaaggaa aggaataaac gggagttctg catgtgagtt ctcaagaaaa ggaaagggag   3180

gctgagcagt ggctgaagcg atgcagcctt gagacacgct gtgagcatcc catccgccgc   3240

cccagcgctg ctggtagcca ggggaggggt ctgcacagcg agaagtactg tgatgacttt   3300

gagccgttga catgtatgtc ttcagatgcc tttctgcctc tgtcgatttt agggtatgga   3360

tattaggagc cataacttgt aatcttgttc tctgaacgta gagataagct gctataaagc   3420

cagtagatgt taaactgaag agaaattatt cccacctgct atgagtcagg cttaaggaat   3480

ctcttcaata gtgtctcttt agtaaaatac caaacatgtc tttgtatcaa ggaacttaaa   3540

atttctcaac aattgtattt tgaacactgt taccctaaaa gtgctgtctc ttcaagtcat   3600

cttttgcagg aagtgagcca agatttgttc tagactccca ttttgcaaaa ggcttacttt   3660

ccacttctgg gctgtatttt gatgtctcat cttcattgtt ttcactctta acttagagct   3720

gcttcaccag tattggggtc agactggcca tcagcacctg agcgtgctga gctccaggta   3780

tagtggaccc cagggtgcct cataccagcc agttagagag catacctttt atttttcagg   3840

gcagaatgac cagtggttct gagtttgagt ttggacagct tcaaagagtg gtccgttcaa   3900

atgtcaaagc aaggtgcctt tggtggcttt gtgaagggtg aaaatcagtg atgggacatt   3960

tactaagtat ttcttttttt tttttttttt ttagttgttg agacagagtt tcactcttgt   4020

tgcccaggct ggagtgaaat ggtgcgatct cggttcaccg caacctccac atcccaggtt   4080

caagtgattc tcctgcctca gcctcctgag tagctaggat tacaggcatg tgccaccatg   4140

taattagccc ggctaatttt gtatttttag tagagacggg atttctccat gttgatcagg   4200

ctggtcatga actcctgacc tcaggtgatc tgcctgcctc agcctcccaa agtgctgctg   4260

ggattacagg cgtgagccac cactcccggc taagttagta tttctttaat cttaatgctt   4320

taaactaagc cacttggatc ctgaataatt taaatcttga gctacattgg taagtaataa   4380

attatttaag gccaggaatt cctgtagttt tcatggagtc tgtagcttta ttaaaaaata   4440

aatcactgcc aggcttcatt cttccatatg atcctctaaa aatggacact tcctctgaat   4500

gctgtatctc atggcacctg gtccaactag aaatggtcaa ggaattcatt tggctccttg   4560

atacatcagt cctcaatatt actttctagg tattttatgg ccagattgct tatatgagtg   4620

gtcttttggt ttggtagtag gtttttattt ttaatttctg tactaatgaa attcctgact   4680

ttaatttctg aaaaccaaaa actctccaag tgtatttatt tatatttttt ttaatagaga   4740

cgaggtcttg ctatgttgcc caggctggtc ccaaactcct ggcctcaagc agtccttcca   4800

ccttggcctc ccaaagtgct gggattatca atatgagcca ccatgccaga tttgttcatt   4860

tttaaacatt tttatctctt caagtcatct tttgatcttt taaaaagcac cttcaaacag   4920

ctgcaccttc catttgcact aggaaatgaa ggtagtgatg ggattggcaa tgttcctggc   4980

agatgtttca gcccaaaagc tcttctacag accggtttag agctggtgcc ctatgagaat   5040

attagggagc ttttatttta aattgaactt tacccttgtc catgcaaggc attcctcctg   5100

aatgcatcca tgaatttgtt tacttttgcg tcaaacatat gagccattgt catgctcagc   5160

ctgtgccacc attgctctgt ctgatgtatg taatcataca agacctgatt ttggttctaa   5220

cacagtggtc tttgactatc aacattgatg tttttagaga tgggttcttc tggttgatac   5280

agactatgca ttgcgtttag cagatggggt aaaactggcc taaaacaagt ctttgcagaa   5340

tacatgccaa tttccaaaaa aaaaaaaaaa tttgttgctc aggtgttgca caatttttat   5400

ctaacactga ggctatcagc tccaactaaa caacatttca gtgggtgagg ctgccctaac   5460

ttccattagg ggccatggtc tcactgccat cacttattag ccatgagaat ttggttgtag   5520

ttttcaggta ggttggtttc ttcctcattt gcagcttgtt gatacttgtt cctttttatt   5580

tattaacatc ccaatcaatt tgcagctgcc atcattacat aaatattttt ctgttataaa   5640

aagaagtgtg atctgttttt ttagtgattt cctttgtttg ggaatagaga ttggaagcac   5700

atactcagac ctgttttgtt aactagaatt ctttaaaagc tgatgccaaa catctttaca   5760

gaggaactgt agttcacatc cacctgtctg acattgtccc ctaaaaacaa gtgcagtgtg   5820

gcagctgctg aatctgtctg ttcagtttgt caaggaggat aattatgctt gggagagatc   5880

tgaaaagaag gtgaatattt tgcacttttg atactcttag gaacaaataa cttatttggc   5940

aaattgtttc ttttttatgt tttgggtgtt gtttttgttt tttgactttt tttgtattgt   6000

gaacaggcac tgaagctgat gttattttaa gattacagaa tggaaaaaga aataaactat   6060

tttaatgtct gat                                                      6073


<210>  5414
<211>  782
<212>  PRT
<213>  Homosapiens

<400>  5414

Met Glu Val Arg Lys Leu Ser Ile Ser Trp Gln Phe Leu Ile Val Leu 
1               5                   10                  15      


Val Leu Ile Leu Gln Ile Leu Ser Ala Leu Asp Phe Asp Pro Tyr Arg 
            20                  25                  30          


Val Leu Gly Val Ser Arg Thr Ala Ser Gln Ala Asp Ile Lys Lys Ala 
        35                  40                  45              


Tyr Lys Lys Leu Ala Arg Glu Trp His Pro Asp Lys Asn Lys Asp Pro 
    50                  55                  60                  


Gly Ala Glu Asp Lys Phe Ile Gln Ile Ser Lys Ala Tyr Glu Ile Leu 
65                  70                  75                  80  


Ser Asn Glu Glu Lys Arg Ser Asn Tyr Asp Gln Tyr Gly Asp Ala Gly 
                85                  90                  95      


Glu Asn Gln Gly Tyr Gln Lys Gln Gln Gln Gln Arg Glu Tyr Arg Phe 
            100                 105                 110         


Arg His Phe His Glu Asn Phe Tyr Phe Asp Glu Ser Phe Phe His Phe 
        115                 120                 125             


Pro Phe Asn Ser Glu Arg Arg Asp Ser Ile Asp Glu Lys Tyr Leu Leu 
    130                 135                 140                 


His Phe Ser His Tyr Val Asn Glu Val Val Pro Asp Ser Phe Lys Lys 
145                 150                 155                 160 


Pro Tyr Leu Ile Lys Ile Thr Ser Asp Trp Cys Phe Ser Cys Ile His 
                165                 170                 175     


Ile Glu Pro Val Trp Lys Glu Val Ile Gln Glu Leu Glu Glu Leu Gly 
            180                 185                 190         


Val Gly Ile Gly Val Val His Ala Gly Tyr Glu Arg Arg Leu Ala His 
        195                 200                 205             


His Leu Gly Ala His Ser Thr Pro Ser Ile Leu Gly Ile Ile Asn Gly 
    210                 215                 220                 


Lys Ile Ser Phe Phe His Asn Ala Val Val Arg Glu Asn Leu Arg Gln 
225                 230                 235                 240 


Phe Val Glu Ser Leu Leu Pro Gly Asn Leu Val Glu Lys Val Thr Asn 
                245                 250                 255     


Lys Asn Tyr Val Arg Phe Leu Ser Gly Trp Gln Gln Glu Asn Lys Pro 
            260                 265                 270         


His Val Leu Leu Phe Asp Gln Thr Pro Ile Val Pro Leu Leu Tyr Lys 
        275                 280                 285             


Leu Thr Ala Phe Ala Tyr Lys Asp Tyr Leu Ser Phe Gly Tyr Val Tyr 
    290                 295                 300                 


Val Gly Leu Arg Gly Thr Glu Glu Met Thr Arg Arg Tyr Asn Ile Asn 
305                 310                 315                 320 


Ile Tyr Ala Pro Thr Leu Leu Val Phe Lys Glu His Ile Asn Arg Pro 
                325                 330                 335     


Ala Asp Val Ile Gln Ala Arg Gly Met Lys Lys Gln Ile Ile Asp Asp 
            340                 345                 350         


Phe Ile Thr Arg Asn Lys Tyr Leu Leu Ala Ala Arg Leu Thr Ser Gln 
        355                 360                 365             


Lys Leu Phe His Glu Leu Cys Pro Val Lys Arg Ser His Arg Gln Arg 
    370                 375                 380                 


Lys Tyr Cys Val Val Leu Leu Thr Ala Glu Thr Thr Lys Leu Ser Lys 
385                 390                 395                 400 


Pro Phe Glu Ala Phe Leu Ser Phe Ala Leu Ala Asn Thr Gln Asp Thr 
                405                 410                 415     


Val Arg Phe Val His Val Tyr Ser Asn Arg Gln Gln Glu Phe Ala Asp 
            420                 425                 430         


Thr Leu Leu Pro Asp Ser Glu Ala Phe Gln Gly Lys Ser Ala Val Ser 
        435                 440                 445             


Ile Leu Glu Arg Arg Asn Thr Ala Gly Arg Val Val Tyr Lys Thr Leu 
    450                 455                 460                 


Glu Asp Pro Trp Ile Gly Ser Glu Ser Asp Lys Phe Ile Leu Leu Gly 
465                 470                 475                 480 


Tyr Leu Asp Gln Leu Arg Lys Asp Pro Ala Leu Leu Ser Ser Glu Ala 
                485                 490                 495     


Val Leu Pro Asp Leu Thr Asp Glu Leu Ala Pro Val Phe Leu Leu Arg 
            500                 505                 510         


Trp Phe Tyr Ser Ala Ser Asp Tyr Ile Ser Asp Cys Trp Asp Ser Ile 
        515                 520                 525             


Phe His Asn Asn Trp Arg Glu Met Met Pro Leu Leu Ser Leu Ile Phe 
    530                 535                 540                 


Ser Ala Leu Phe Ile Leu Phe Gly Thr Val Ile Val Gln Ala Phe Ser 
545                 550                 555                 560 


Asp Ser Asn Asp Glu Arg Glu Ser Ser Pro Pro Glu Lys Glu Glu Ala 
                565                 570                 575     


Gln Glu Lys Thr Gly Lys Thr Glu Pro Ser Phe Thr Lys Glu Asn Ser 
            580                 585                 590         


Ser Lys Ile Pro Lys Lys Gly Phe Val Glu Val Thr Glu Leu Thr Asp 
        595                 600                 605             


Val Thr Tyr Thr Ser Asn Leu Val Arg Leu Arg Pro Gly His Met Asn 
    610                 615                 620                 


Val Val Leu Ile Leu Ser Asn Ser Thr Lys Thr Ser Leu Leu Gln Lys 
625                 630                 635                 640 


Phe Ala Leu Glu Val Tyr Thr Phe Thr Gly Ser Ser Cys Leu His Phe 
                645                 650                 655     


Ser Phe Leu Ser Leu Asp Lys His Arg Glu Trp Leu Glu Tyr Leu Leu 
            660                 665                 670         


Glu Phe Ala Gln Asp Ala Ala Pro Ile Pro Asn Gln Tyr Asp Lys His 
        675                 680                 685             


Phe Met Glu Arg Asp Tyr Thr Gly Tyr Val Leu Ala Leu Asn Gly His 
    690                 695                 700                 


Lys Lys Tyr Phe Cys Leu Phe Lys Pro Gln Lys Thr Val Glu Glu Glu 
705                 710                 715                 720 


Glu Ala Ile Gly Ser Cys Ser Asp Val Asp Ser Ser Leu Tyr Leu Gly 
                725                 730                 735     


Glu Ser Arg Gly Lys Pro Ser Cys Gly Leu Gly Ser Arg Pro Ile Lys 
            740                 745                 750         


Gly Lys Leu Ser Lys Leu Ser Leu Trp Met Glu Arg Leu Leu Glu Gly 
        755                 760                 765             


Ser Leu Gln Arg Phe Tyr Ile Pro Ser Trp Pro Glu Leu Asp 
    770                 775                 780         


<210>  5415
<211>  3990
<212>  DNA
<213>  Homosapiens

<400>  5415
acctttaagc gtcacgtgac tcccctcggg cttgtcccct cctctttccc ctccccaggc     60

ccaggcgagc gctggtgtgg acgggaagct cccggcccgg cgaactaact ggagcacgga    120

gctgcagccg gttgggccgg tgtactttcc cgctctggaa aggaagagaa atggaagtga    180

gaaagttgag catttcctgg cagttcttga tagttctggt tctgatcctg caaattctgt    240

ctgcgttgga ttttgaccca tacagagtcc taggggtcag ccgaacagcc agtcaggctg    300

atattaaaaa ggcttataag aagctcgccc gggaatggca tcctgacaaa aacaaagatc    360

ctggagcaga agacaagttc attcaaatca gtaaggctta cgagattctt tcaaatgaag    420

aaaagagatc aaattatgat caatatggag acgctggaga gaaccagggc taccagaagc    480

agcaacagca gcgagagtat cgcttccgcc atttccatga aaatttttat tttgatgaat    540

ccttttttca cttccctttt aattctgaac ggcgggactc aattgacgaa aagtatttat    600

tgcacttttc acattatgtg aatgaagtgg ttccagatag cttcaagaaa ccctacctca    660

tcaagatcac ctccgattgg tgctttagct gcattcatat cgagcctgtg tggaaagaag    720

tcattcaaga actggaagaa ttgggtgtag gaattggcgt ggtccatgct gggtatgaga    780

gacgcctggc ccatcaccta ggggcacaca gcacgccctc tatcctagga atcattaacg    840

ggaaaatctc cttcttccac aatgcagttg tccgtgaaaa tctgcgacaa tttgtagaaa    900

gtcttcttcc agggaacttg gtggagaaag ttacaaataa aaattacgtc agattcctct    960

ctggctggca gcaagagaat aagcctcatg tccttctgtt tgaccaaacg cccattgtgc   1020

cactgttata caagttgact gcctttgcat acaaagatta tttatcattt ggatatgtat   1080

atgtgggttt gagagggacg gaagagatga caaggcggta caacatcaat atctacgccc   1140

ctaccctctt ggtctttaaa gaacatataa acaggcctgc cgatgttatc caggcccgag   1200

gtatgaagaa gcaaatcatt gacgacttca tcacccgaaa caaatatcta ttggcagcca   1260

ggctcaccag ccagaagttg ttccatgaac tctgccctgt gaaacggtcg catcgacaga   1320

ggaagtactg tgtggtttta ttgactgctg agactaccaa gttgagcaaa ccctttgagg   1380

ctttcctgtc ctttgccctg gcaaacactc aagacacagt gagatttgtg catgtctaca   1440

gcaatcggca gcaggagttt gccgacacct tactaccaga cagtgaggcg tttcaaggga   1500

aatcagcggt gtctatttta gaaaggcgca acacagcagg aagggtggtg tataaaaccc   1560

tggaagaccc ttggattggg agtgagagtg acaaatttat cctcttgggc tatctcgacc   1620

agctgcgtaa agatccagct cttctgtcct ctgaagcagt gcttcctgac ctgaccgatg   1680

aacttgcccc tgtttttctc cttcgatggt tctactctgc ttctgactac atctcagact   1740

gctgggatag catttttcac aacaactgga gggaaatgat gcccctgctg tccctgatct   1800

tctctgccct cttcatcctc ttcggcactg tcatcgttca ggctttcagc gactctaatg   1860

atgagcgaga gtcaagccct ccagaaaaag aggaagccca agagaagact gggaaaactg   1920

agccaagctt caccaaagaa aacagcaggt ttctctaaca aaacaccaga ctcacctccc   1980

cggcacctgc cccccagatc ctgtcatctg ataacgcagc attggaacat agagtgtaga   2040

gaagaactct catgcacctc ctcccatgta aactgtggct acagggaaaa gtcactgtga   2100

tttgtgttta ctaagaccct gtaggtgttt agatgcctta gatttcataa tgaaggcaga   2160

aggaaagaag cctatcaggc aagtgttagg tgagccagaa gcaggacgtg gtttatccct   2220

gtaaatgtca atgaacgtaa ccagtcttgt gcgcacacac acccagcagc aagaggccag   2280

ggtctccgag acaaagaaca tagactgaat gatagttgtc ttcttcattc tgtcctagag   2340

caacttctgc acctgaaaag caccaccatg ccagatttgt tcatttttaa acatttttat   2400

ctcttcaagt catcttttga tcttttaaaa agcaccttca aacagctgca ccttccattt   2460

gcactaggaa atgaaggtag tgatgggatt ggcaatgttc ctggcagatg tttcagccca   2520

aaagctcttc tacagaccgg tttagagctg gtgccctatg agaatattag ggagctttta   2580

ttttaaattg aactttaccc ttgtccatgc aaggcattcc tcctgaatgc atccatgaat   2640

ttgtttactt ttgcgtcaaa catatgagcc attgtcatgc tcagcctgtg ccaccattgc   2700

tctgtctgat gtatgtaatc atacaagacc tgattttggt tctaacacag tggtctttga   2760

ctatcaacat tgatgttttt agagatgggt tcttctggtt gatacagact atgcattgcg   2820

tttagcagat ggggtaaaac tggcctaaaa caagtctttg cagaatacat gccaatttcc   2880

aaaaaaaaaa aaaaatttgt tgctcaggtg ttgcacaatt tttatctaac actgaggcta   2940

tcagctccaa ctaaacaaca tttcagtggg tgaggctgcc ctaacttcca ttaggggcca   3000

tggtctcact gccatcactt attagccatg agaatttggt tgtagttttc aggtaggttg   3060

gtttcttcct catttgcagc ttgttgatac ttgttccttt ttatttatta acatcccaat   3120

caatttgcag ctgccatcat tacataaata tttttctgtt ataaaaagaa gtgtgatctg   3180

tttttttagt gatttccttt gtttgggaat agagattgga agcacatact cagacctgtt   3240

ttgttaacta gaattcttta aaagctgatg ccaaacatct ttacagagga actgtagttc   3300

acatccacct gtctgacatt gtcccctaaa aacaagtgca gtgtggcagc tgctgaatct   3360

gtctgttcag tttgtcaagg aggataatta tgcttgggag agatctgaaa agaaggtgaa   3420

tattttgcac ttttgatact cttaggaaca aataacttat ttggcaaatt gtttcttttt   3480

tatgttttgg gtgttgtttt tgttttttga ctttttttgt attgtgaaca ggcactgaag   3540

ctgatgttat tttaagatta cagaatggaa aaagaaataa actattttaa tgtctgataa   3600

ttatggggta gcccttgcat tgcaagatga tgatttgatt atggacacat tatcaacaga   3660

attgaatttg catggaactc aagacacgct taagatcacc acagcataac tgcagatttc   3720

aggaattaca gtcatagagg gtacatcaac ttgaagagta gattgagtct tacaggaagt   3780

gagttacaat aagtaacatt aagagcccag ctgccagcct ggccaacatg gtgaaacccc   3840

gtctctacta aaaatacaaa aattagccgg gcgtggtgac gcatgactgt aattctagct   3900

actcaggagg ctgaggcagc agaattgctt gaacccagga ggcggagatt gcagtgagct   3960

aagatcgggc cactgcactc cagcctgggg                                    3990


<210>  5416
<211>  595
<212>  PRT
<213>  Homosapiens

<400>  5416

Met Glu Val Arg Lys Leu Ser Ile Ser Trp Gln Phe Leu Ile Val Leu 
1               5                   10                  15      


Val Leu Ile Leu Gln Ile Leu Ser Ala Leu Asp Phe Asp Pro Tyr Arg 
            20                  25                  30          


Val Leu Gly Val Ser Arg Thr Ala Ser Gln Ala Asp Ile Lys Lys Ala 
        35                  40                  45              


Tyr Lys Lys Leu Ala Arg Glu Trp His Pro Asp Lys Asn Lys Asp Pro 
    50                  55                  60                  


Gly Ala Glu Asp Lys Phe Ile Gln Ile Ser Lys Ala Tyr Glu Ile Leu 
65                  70                  75                  80  


Ser Asn Glu Glu Lys Arg Ser Asn Tyr Asp Gln Tyr Gly Asp Ala Gly 
                85                  90                  95      


Glu Asn Gln Gly Tyr Gln Lys Gln Gln Gln Gln Arg Glu Tyr Arg Phe 
            100                 105                 110         


Arg His Phe His Glu Asn Phe Tyr Phe Asp Glu Ser Phe Phe His Phe 
        115                 120                 125             


Pro Phe Asn Ser Glu Arg Arg Asp Ser Ile Asp Glu Lys Tyr Leu Leu 
    130                 135                 140                 


His Phe Ser His Tyr Val Asn Glu Val Val Pro Asp Ser Phe Lys Lys 
145                 150                 155                 160 


Pro Tyr Leu Ile Lys Ile Thr Ser Asp Trp Cys Phe Ser Cys Ile His 
                165                 170                 175     


Ile Glu Pro Val Trp Lys Glu Val Ile Gln Glu Leu Glu Glu Leu Gly 
            180                 185                 190         


Val Gly Ile Gly Val Val His Ala Gly Tyr Glu Arg Arg Leu Ala His 
        195                 200                 205             


His Leu Gly Ala His Ser Thr Pro Ser Ile Leu Gly Ile Ile Asn Gly 
    210                 215                 220                 


Lys Ile Ser Phe Phe His Asn Ala Val Val Arg Glu Asn Leu Arg Gln 
225                 230                 235                 240 


Phe Val Glu Ser Leu Leu Pro Gly Asn Leu Val Glu Lys Val Thr Asn 
                245                 250                 255     


Lys Asn Tyr Val Arg Phe Leu Ser Gly Trp Gln Gln Glu Asn Lys Pro 
            260                 265                 270         


His Val Leu Leu Phe Asp Gln Thr Pro Ile Val Pro Leu Leu Tyr Lys 
        275                 280                 285             


Leu Thr Ala Phe Ala Tyr Lys Asp Tyr Leu Ser Phe Gly Tyr Val Tyr 
    290                 295                 300                 


Val Gly Leu Arg Gly Thr Glu Glu Met Thr Arg Arg Tyr Asn Ile Asn 
305                 310                 315                 320 


Ile Tyr Ala Pro Thr Leu Leu Val Phe Lys Glu His Ile Asn Arg Pro 
                325                 330                 335     


Ala Asp Val Ile Gln Ala Arg Gly Met Lys Lys Gln Ile Ile Asp Asp 
            340                 345                 350         


Phe Ile Thr Arg Asn Lys Tyr Leu Leu Ala Ala Arg Leu Thr Ser Gln 
        355                 360                 365             


Lys Leu Phe His Glu Leu Cys Pro Val Lys Arg Ser His Arg Gln Arg 
    370                 375                 380                 


Lys Tyr Cys Val Val Leu Leu Thr Ala Glu Thr Thr Lys Leu Ser Lys 
385                 390                 395                 400 


Pro Phe Glu Ala Phe Leu Ser Phe Ala Leu Ala Asn Thr Gln Asp Thr 
                405                 410                 415     


Val Arg Phe Val His Val Tyr Ser Asn Arg Gln Gln Glu Phe Ala Asp 
            420                 425                 430         


Thr Leu Leu Pro Asp Ser Glu Ala Phe Gln Gly Lys Ser Ala Val Ser 
        435                 440                 445             


Ile Leu Glu Arg Arg Asn Thr Ala Gly Arg Val Val Tyr Lys Thr Leu 
    450                 455                 460                 


Glu Asp Pro Trp Ile Gly Ser Glu Ser Asp Lys Phe Ile Leu Leu Gly 
465                 470                 475                 480 


Tyr Leu Asp Gln Leu Arg Lys Asp Pro Ala Leu Leu Ser Ser Glu Ala 
                485                 490                 495     


Val Leu Pro Asp Leu Thr Asp Glu Leu Ala Pro Val Phe Leu Leu Arg 
            500                 505                 510         


Trp Phe Tyr Ser Ala Ser Asp Tyr Ile Ser Asp Cys Trp Asp Ser Ile 
        515                 520                 525             


Phe His Asn Asn Trp Arg Glu Met Met Pro Leu Leu Ser Leu Ile Phe 
    530                 535                 540                 


Ser Ala Leu Phe Ile Leu Phe Gly Thr Val Ile Val Gln Ala Phe Ser 
545                 550                 555                 560 


Asp Ser Asn Asp Glu Arg Glu Ser Ser Pro Pro Glu Lys Glu Glu Ala 
                565                 570                 575     


Gln Glu Lys Thr Gly Lys Thr Glu Pro Ser Phe Thr Lys Glu Asn Ser 
            580                 585                 590         


Arg Phe Leu 
        595 


<210>  5417
<211>  3447
<212>  DNA
<213>  Homosapiens

<400>  5417
acctttaagc gtcacgtgac tcccctcggg cttgtcccct cctctttccc ctccccaggc     60

ccaggcgagc gctggtgtgg acgggaagct cccggcccgg cgaactaact ggagcacgga    120

gctgcagccg gttgggccgg tgtactttcc cgctctggaa aggaagagaa atggaagtga    180

gaaagttgag catttcctgg cagttcttga tagttctggt tctgatcctg caaattctgt    240

ctgcgttgga ttttgaccca tacagagtcc taggggtcag ccgaacagcc agtcaggctg    300

atattaaaaa ggcttataag aagctcgccc gggaatggca tcctgacaaa aacaaagatc    360

ctggagcaga agacaagttc attcaaatca gtaaggctta cgagattctt tcaaatgaag    420

aaaagagatc aaattatgat caatatggag acgctggaga gaaccagggc taccagaagc    480

agcaacagca gcgagagtat cgcttccgcc atttccatga aaatttttat tttgatgaat    540

ccttttttca cttccctttt aattctgaac ggcgggactc aattgacgaa aagtatttat    600

tgcacttttc acattatgtg aatgaagtgg ttccagatag cttcaagaaa ccctacctca    660

tcaagatcac ctccgattgg tgctttagct gcattcatat cgagcctgtg tggaaagaag    720

tcattcaaga actggaagaa ttgggtgtag gaattggcgt ggtccatgct gggtatgaga    780

gacgcctggc ccatcaccta ggggcacaca gcacgccctc tatcctagga atcattaacg    840

ggaaaatctc cttcttccac aatgcagttg tccgtgaaaa tctgcgacaa tttgtagaaa    900

gtcttcttcc agggaacttg gtggagaaag ttacaaataa aaattacgtc agattcctct    960

ctggctggca gcaagagaat aagcctcatg tccttctgtt tgaccaaacg cccattgtgc   1020

cactgttata caagttgact gcctttgcat acaaagatta tttatcattt ggatatgtat   1080

atgtgggttt gagagggacg gaagagatga caaggcggta caacatcaat atctacgccc   1140

ctaccctctt ggtctttaaa gaacatataa acaggcctgc cgatgttatc caggcccgag   1200

gtatgaagaa gcaaatcatt gacgacttca tcacccgaaa caaatatcta ttggcagcca   1260

ggctcaccag ccagaagttg ttccatgaac tctgccctgt gaaacggtcg catcgacaga   1320

ggaagtactg tgtggtttta ttgactgctg agactaccaa gttgagcaaa ccctttgagg   1380

ctttcctgtc ctttgccctg gcaaacactc aagacacagt gagatttgtg catgtctaca   1440

gcaatcggca gcaggagttt gccgacacct tactaccaga cagtgaggcg tttcaaggga   1500

aatcagcggt gtctatttta gaaaggcgca acacagcagg aagggtggtg tataaaaccc   1560

tggaagaccc ttggattggg agtgagagtg acaaatttat cctcttgggc tatctcgacc   1620

agctgcgtaa agatccagct cttctgtcct ctgaagcagt gcttcctgac ctgaccgatg   1680

aacttgcccc tgtttttctc cttcgatggt tctactctgc ttctgactac atctcagact   1740

gctgggatag catttttcac aacaactgga gggaaatgat gcccctgctg tccctgatct   1800

tctctgccct cttcatcctc ttcggcactg tcatcgttca ggctttcagc gactctaatg   1860

atgagcgaga gtcaagccct ccagaaaaag aggaagccca agagaagact gggaaaactg   1920

agccaagctt caccaaagaa aacagcagca agattcctaa aaaaggcttt gtggaggtaa   1980

ctgaactcac agatgtaaca tacaccagta acttggtacg tctgaggcca ggccacatga   2040

atgtggtcct catcctgtcg aattctacca agaccagcct actacagaaa tttgctttgg   2100

aggtctacac atttactgga aagatcatac ggtggtgaaa cttcgacaag atcacagccc   2160

atcacgttca ggccttgaca acccctgatg atctccagag cctattcaag atcaagactg   2220

agttgtccac agtggtaatc atttacagtg aaaagcaccc agtagagctt ttcccagccc   2280

acgccaccct ttgacttgga attggctttc cctccataaa catttgttga ctgccaggca   2340

cactggcagg cctcccagag aaacagataa tgcgtacaca gtccctgctc ctcagggctg   2400

catggtgtgg tgatggagac aaggaaacca atcgtttcaa tgtcatgcac caagggcttc   2460

aaggaaagca agcccagaat ggtatcagca taggtaatag cctggagagg tgggtaaggc   2520

ttccccaagg tggaaatacc cagttcaagg gataggccag gcagagggaa aaacacaggc   2580

aaaggcacca agatgggaaa agttcaggta gtaagatgtg gccagaagac agagtaagtg   2640

agggagactg atgggaagag agtgaccttg tctgaaaggg ttcccatcct gcaggtgaaa   2700

agcccagaag gttgctaagc agagggatga ggaatgtgtt tcagaaatcc ctcatgagaa   2760

gagaggatgg ttacagccat ttcaagagag agagttatgg ccaccctcct ttaagatctt   2820

agaggatgta aggtacttga ttaggtttaa gcagtcttca ttcatttact ctcaaatgtc   2880

tttgagtgcc tactatttgt attaggcact gtcctaggct ccaaggacaa ggtagggaac   2940

aatacatagg tcctgccctt ggggagattc tagtcataac cattctgccc ccgtgcattt   3000

actcccagca cacattattg gagctttatt tgggtgtttc taaaactctt gagcttacct   3060

tggcaggtaa ttgtgccatc acatgcactt ttatttattt atttatttat ttatttattt   3120

atttatttat ttttgagaca gggtctctgt cacccgggct atagtgcagt ggtatgatca   3180

cggctcactg aaggcttgac ctgccaggct cagttgatcc tcctgcccca gcctccctag   3240

tagctgggac tacaggtgca cactagcaca ccagactaat ttttattttt atttttagta   3300

aagatgggat ctcactatgt tgcccaggct gggctgaaac tcctgggctc aaacgatcca   3360

tccaccctgg cctcccaaag tgctgaggat agtgcctgag ccaccgcgcc tggcccgttg   3420

tatgcacttt tatttaaatt taaccct                                       3447


<210>  5418
<211>  655
<212>  PRT
<213>  Homosapiens

<400>  5418

Met Glu Val Arg Lys Leu Ser Ile Ser Trp Gln Phe Leu Ile Val Leu 
1               5                   10                  15      


Val Leu Ile Leu Gln Ile Leu Ser Ala Leu Asp Phe Asp Pro Tyr Arg 
            20                  25                  30          


Val Leu Gly Val Ser Arg Thr Ala Ser Gln Ala Asp Ile Lys Lys Ala 
        35                  40                  45              


Tyr Lys Lys Leu Ala Arg Glu Trp His Pro Asp Lys Asn Lys Asp Pro 
    50                  55                  60                  


Gly Ala Glu Asp Lys Phe Ile Gln Ile Ser Lys Ala Tyr Glu Ile Leu 
65                  70                  75                  80  


Ser Asn Glu Glu Lys Arg Ser Asn Tyr Asp Gln Tyr Gly Asp Ala Gly 
                85                  90                  95      


Glu Asn Gln Gly Tyr Gln Lys Gln Gln Gln Gln Arg Glu Tyr Arg Phe 
            100                 105                 110         


Arg His Phe His Glu Asn Phe Tyr Phe Asp Glu Ser Phe Phe His Phe 
        115                 120                 125             


Pro Phe Asn Ser Glu Arg Arg Asp Ser Ile Asp Glu Lys Tyr Leu Leu 
    130                 135                 140                 


His Phe Ser His Tyr Val Asn Glu Val Val Pro Asp Ser Phe Lys Lys 
145                 150                 155                 160 


Pro Tyr Leu Ile Lys Ile Thr Ser Asp Trp Cys Phe Ser Cys Ile His 
                165                 170                 175     


Ile Glu Pro Val Trp Lys Glu Val Ile Gln Glu Leu Glu Glu Leu Gly 
            180                 185                 190         


Val Gly Ile Gly Val Val His Ala Gly Tyr Glu Arg Arg Leu Ala His 
        195                 200                 205             


His Leu Gly Ala His Ser Thr Pro Ser Ile Leu Gly Ile Ile Asn Gly 
    210                 215                 220                 


Lys Ile Ser Phe Phe His Asn Ala Val Val Arg Glu Asn Leu Arg Gln 
225                 230                 235                 240 


Phe Val Glu Ser Leu Leu Pro Gly Asn Leu Val Glu Lys Val Thr Asn 
                245                 250                 255     


Lys Asn Tyr Val Arg Phe Leu Ser Gly Trp Gln Gln Glu Asn Lys Pro 
            260                 265                 270         


His Val Leu Leu Phe Asp Gln Thr Pro Ile Val Pro Leu Leu Tyr Lys 
        275                 280                 285             


Leu Thr Ala Phe Ala Tyr Lys Asp Tyr Leu Ser Phe Gly Tyr Val Tyr 
    290                 295                 300                 


Val Gly Leu Arg Gly Thr Glu Glu Met Thr Arg Arg Tyr Asn Ile Asn 
305                 310                 315                 320 


Ile Tyr Ala Pro Thr Leu Leu Val Phe Lys Glu His Ile Asn Arg Pro 
                325                 330                 335     


Ala Asp Val Ile Gln Ala Arg Gly Met Lys Lys Gln Ile Ile Asp Asp 
            340                 345                 350         


Phe Ile Thr Arg Asn Lys Tyr Leu Leu Ala Ala Arg Leu Thr Ser Gln 
        355                 360                 365             


Lys Leu Phe His Glu Leu Cys Pro Val Lys Arg Ser His Arg Gln Arg 
    370                 375                 380                 


Lys Tyr Cys Val Val Leu Leu Thr Ala Glu Thr Thr Lys Leu Ser Lys 
385                 390                 395                 400 


Pro Phe Glu Ala Phe Leu Ser Phe Ala Leu Ala Asn Thr Gln Asp Thr 
                405                 410                 415     


Val Arg Phe Val His Val Tyr Ser Asn Arg Gln Gln Glu Phe Ala Asp 
            420                 425                 430         


Thr Leu Leu Pro Asp Ser Glu Ala Phe Gln Gly Lys Ser Ala Val Ser 
        435                 440                 445             


Ile Leu Glu Arg Arg Asn Thr Ala Gly Arg Val Val Tyr Lys Thr Leu 
    450                 455                 460                 


Glu Asp Pro Trp Ile Gly Ser Glu Ser Asp Lys Phe Ile Leu Leu Gly 
465                 470                 475                 480 


Tyr Leu Asp Gln Leu Arg Lys Asp Pro Ala Leu Leu Ser Ser Glu Ala 
                485                 490                 495     


Val Leu Pro Asp Leu Thr Asp Glu Leu Ala Pro Val Phe Leu Leu Arg 
            500                 505                 510         


Trp Phe Tyr Ser Ala Ser Asp Tyr Ile Ser Asp Cys Trp Asp Ser Ile 
        515                 520                 525             


Phe His Asn Asn Trp Arg Glu Met Met Pro Leu Leu Ser Leu Ile Phe 
    530                 535                 540                 


Ser Ala Leu Phe Ile Leu Phe Gly Thr Val Ile Val Gln Ala Phe Ser 
545                 550                 555                 560 


Asp Ser Asn Asp Glu Arg Glu Ser Ser Pro Pro Glu Lys Glu Glu Ala 
                565                 570                 575     


Gln Glu Lys Thr Gly Lys Thr Glu Pro Ser Phe Thr Lys Glu Asn Ser 
            580                 585                 590         


Ser Lys Ile Pro Lys Lys Gly Phe Val Glu Val Thr Glu Leu Thr Asp 
        595                 600                 605             


Val Thr Tyr Thr Ser Asn Leu Val Arg Leu Arg Pro Gly His Met Asn 
    610                 615                 620                 


Val Val Leu Ile Leu Ser Asn Ser Thr Lys Thr Ser Leu Leu Gln Lys 
625                 630                 635                 640 


Phe Ala Leu Glu Val Tyr Thr Phe Thr Gly Lys Ile Ile Arg Trp 
                645                 650                 655 


<210>  5419
<211>  2847
<212>  DNA
<213>  Homosapiens

<400>  5419
agttgttcca tgaactctgc cctgtgaaac ggtcgcatcg acagaggaat ccagggcact     60

ttagcaccaa attgtcagat gtgccagcct gtcctagtgg tcagagaaga tttccctaag    120

atgtaacatt tcagctgaga cctgaaggat gagcacagtt tagccaggcg tctgggatag    180

actgggtcac tttacagaag cacagaatat ggaagagtga ctgtccctac taaagcattc    240

cacacagggt actgtgtggt tttattgact gctgagacta ccaagttgag caaacccttt    300

gaggctttcc tgtcctttgc cctggcaaac actcaagaca cagtgagatt tgtgcatgtc    360

tacagcaatc ggcagcagga gtttgccgac accttactac cagacagtga ggcgtttcaa    420

gggaaatcag cggtgtctat tttagaaagg cgcaacacag caggaagggt ggtgtataaa    480

accctggaag acccttggat tgggagtgag agtgacaaat ttatcctctt gggctatctc    540

gaccagctgc gtaaagatcc agctcttctg tcctctgaag cagtgcttcc tgacctgacc    600

gatgaacttg cccctgtttt tctccttcga tggttctact ctgcttctga ctacatctca    660

gactgctggg atagcatttt tcacaacaac tggaaaggat cacccatggc tgccattctg    720

ggcagcagag cctgggactg tctcttcatc agggaacctc tggtgcccag cacagggcct    780

gacacacgtg gagtccagtg tatagatgta aaaggaatga gtgaattaac ctcaagaggg    840

atacccactc ccacctactg atgagaccat gagcccctga aggacagaac cacatctcat    900

tcgtgtttgt gattcctggc acccaacaca gcacctgaca aatgacagcc tttgatgggt    960

gttggaggga aatgatgccc ctgctgtccc tgatcttctc tgccctcttc atcctcttcg   1020

gcactgtcat cgttcaggct ttcagcgact ctaatgatga gcgagagtca agccctccag   1080

aaaaagagga agcccaagag aagactggga aaactgagcc aagcttcacc aaagaaaaca   1140

gcaggtttct ctaacaaaac accagactca cctccccggc acctgccccc cagatcctgt   1200

catctgataa cgcagcattg gaacatagag tgtagagaag aactctcatg cacctcctcc   1260

catgtaaact gtggctacag ggaaaagtca ctgtgatttg tgtttactaa gaccctgtag   1320

gtgtttagat gccttagatt tcataatgaa ggcagaagga aagaagccta tcaggcaagt   1380

attcctaaaa aaggctttgt ggaggtaact gaactcacag atgtaacata caccagtaac   1440

ttggtacgtc tgaggccagg ccacatgaat gtggtcctca tcctgtcgaa ttctaccaag   1500

accagcctac tacagaaatt tgctttggag gtctacacat ttactgggag cagctgccta   1560

cacttctcct tcctgagtct agataaacac agagaatggc tagaatactt actagaattt   1620

gctcaagatg cagctccaat cccaaaccaa tatgataagc atttcatgga gcgtgactac   1680

actggttatg tactggctct gaatggccac aagaaatact tctgcctctt caagccccaa   1740

aagacagtcg aagaggagga agccataggg tcgtgcagtg atgttgactc ttccctctac   1800

ctgggtgaat ctcgagggaa accttcctgt ggccttggat ccaggcccat caaaggaaag   1860

ttgagcaagc tctctttatg gatggaacgc ctgctggagg gctccttaca gaggttttat   1920

atcccatcat ggcctgaact agactgagag gattttccaa agagatttga actcttcaga   1980

ctttttaaca tgcccctgtg aacaggttga aaaggaaagg aataaacggg agttctgcat   2040

gtgagttctc aagaaaagga aagggaggct gagcagtggc tgaagcgatg cagccttgag   2100

acacgctgtg agcatcccat ccgccgcccc agcgctgctg gtagccaggg gaggggtctg   2160

cacagcgaga agtactgtga tgactttgag ccgttgacat aaagatcata cggtggtgaa   2220

acttcgacaa gatcacagcc catcacgttc aggccttgac aacccctgat gatctccaga   2280

gcctattcaa gatcaagact gagttgtcca cagtggtaat catttacagt gaaaagcacc   2340

cagtagagct tttcccagcc cacgccaccc tttgacttgg aattggcttt ccctccataa   2400

acatttgttg actgccaggc acactggcag gcctcccaga gaaacagata atgcgtacac   2460

agtccctgct cctcagggct gcatggtgtg gtgatggaga caaggaaacc aatcgtttca   2520

atgtcatgca ccaagggctt caaggaaagc aagcccagaa tggtatcagc ataggtaata   2580

gcctggagag gtgaaaagcc cagaaggttg ctaagcagag ggatgaggaa tgtgtttcag   2640

aaatccctca tgagaagaga ggatggttac agccatttca agagagagag ttatggccac   2700

cctcctttaa gatcttagag gatgtaagga agaaggttga gaagtaccca tctagtaaac   2760

tataatttcc aatatctact tcaacctttt gggtgtcctc caagggcagt accttgtaaa   2820

acacaaggaa taaatgtttt gtgagtg                                       2847


<210>  5420
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  5420

Met Asn Val Val Leu Ile Leu Ser Asn Ser Thr Lys Thr Ser Leu Leu 
1               5                   10                  15      


Gln Lys Phe Ala Leu Glu Val Tyr Thr Phe Thr Gly Ser Ser Cys Leu 
            20                  25                  30          


His Phe Ser Phe Leu Ser Leu Asp Lys His Arg Glu Trp Leu Glu Tyr 
        35                  40                  45              


Leu Leu Glu Phe Ala Gln Asp Ala Ala Pro Ile Pro Asn Gln Tyr Asp 
    50                  55                  60                  


Lys His Phe Met Glu Arg Asp Tyr Thr Gly Tyr Val Leu Ala Leu Asn 
65                  70                  75                  80  


Gly His Lys Lys Tyr Phe Cys Leu Phe Lys Pro Gln Lys Thr Val Glu 
                85                  90                  95      


Glu Glu Glu Ala Ile Gly Ser Cys Ser Asp Val Asp Ser Ser Leu Tyr 
            100                 105                 110         


Leu Gly Glu Ser Arg Gly Lys Pro Ser Cys Gly Leu Gly Ser Arg Pro 
        115                 120                 125             


Ile Lys Gly Lys Leu Ser Lys Leu Ser Leu Trp Met Glu Arg Leu Leu 
    130                 135                 140                 


Glu Gly Ser Leu Gln Arg Phe Tyr Ile Pro Ser Trp Pro Glu Leu Asp 
145                 150                 155                 160 


<210>  5421
<211>  451
<212>  DNA
<213>  Homosapiens

<400>  5421
gtttcaccat gttggtaagg ctggtctcga actcctgacc tcaggtgatc cacccacctc     60

agcctcccaa agtgctggga ttacaggcgt gtgccaccat gcccggccac ttcccttttt    120

ttatattggc tgactgaccc tttcccactg gctaggaaag gatcacccat ggctgccatt    180

ctgggcagca gagcctggga ctgtctcttc atcagggaac ctctggtgcc cagcacaggg    240

cctgacacac gtggagtcca gtgtatagat gtaaaaggaa tgagtgaatt aacctcaaga    300

gggataccca ctcccaccta ctgatgagac catgagcccc tgaaggacag aaccacatct    360

cattcgtgtt tgtgattcct ggcacccaac acagcacctg acaaatgaca gcctttgatg    420

ggtgttggag ggaaatgatg cccctgctgt c                                   451


<210>  5422
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  5422

Met Ala Ala Ile Leu Gly Ser Arg Ala Trp Asp Cys Leu Phe Ile Arg 
1               5                   10                  15      


Glu Pro Leu Val Pro Ser Thr Gly Pro Asp Thr Arg Gly Val Gln Cys 
            20                  25                  30          


Ile Asp Val Lys Gly Met Ser Glu Leu Thr Ser Arg Gly Ile Pro Thr 
        35                  40                  45              


Pro Thr Tyr 
    50      


<210>  5423
<211>  513
<212>  DNA
<213>  Homosapiens

<400>  5423
ttattggtgt gaagagtttt tggtttggga tttttatttt atcttttttt agctggagag     60

aagaaatttt aacttgagct aatagtttgt taatttggtt ttaggaggga aatgatgccc    120

ctgctgtccc tgatcttctc tgccctcttc atcctcttcg gcactgtcat cgttcaggct    180

ttcagcgact ctaatgatga gcgagagtca agccctccag aaaaagagga agcccaagag    240

aagactggga aaactgagcc aagcttcacc aaagaaaaca gcaggtttct ctaacaaaac    300

accagactca cctccccggc acctgccccc cagatcctgt catctgataa cgcagcattg    360

gaacatagag tgtagagaag aactctcatg cacctcctcc catgtaaact gtggctacag    420

ggaaaagtca ctgtgatttg tgtttactaa gaccctgtag gtgtttagat gccttagatt    480

tcataatgaa ggcagaagga aagaagccta tca                                 513


<210>  5424
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  5424

Met Met Pro Leu Leu Ser Leu Ile Phe Ser Ala Leu Phe Ile Leu Phe 
1               5                   10                  15      


Gly Thr Val Ile Val Gln Ala Phe Ser Asp Ser Asn Asp Glu Arg Glu 
            20                  25                  30          


Ser Ser Pro Pro Glu Lys Glu Glu Ala Gln Glu Lys Thr Gly Lys Thr 
        35                  40                  45              


Glu Pro Ser Phe Thr Lys Glu Asn Ser Arg Phe Leu 
    50                  55                  60  


<210>  5425
<211>  818
<212>  DNA
<213>  Homosapiens

<400>  5425
acggctttcc ccctatcctg acagcatctt aactcctcaa tatttctcca cagcaagatt     60

cctaaaaaag gctttgtgga ggtaactgaa ctcacagatg taacatacac cagtaacttg    120

gtacgtctga ggccaggcca catgaatgtg gtcctcatcc tgtcgaattc taccaagacc    180

agcctactac agaaatttgc tttggaggtc tacacattta ctgggagcag ctgcctacac    240

ttctccttcc tgagtctaga taaacacaga gaatggctag aatacttact agaatttgct    300

caagatgcag ctccaatccc aaaccaatat gataagcatt tcatggagcg tgactacact    360

ggttatgtac tggctctgaa tggccacaag aaatacttct gcctcttcaa gccccaaaag    420

acagtcgaag aggaggaagc catagggtcg tgcagtgatg ttgactcttc cctctacctg    480

ggtgaatctc gagggaaacc ttcctgtggc cttggatcca ggcccatcaa aggaaagttg    540

agcaagctct ctttatggat ggaacgcctg ctggagggct ccttacagag gttttatatc    600

ccatcatggc ctgaactaga ctgagaggat tttccaaaga gatttgaact cttcagactt    660

tttaacatgc ccctgtgaac aggtattttc aggactcaaa ctaccacaat gaacagagta    720

tagattttag attgctcttc tagaaccatg gctagaagaa tctttccttt gtcctgttct    780

aacctaggaa tgaaaaacac caccagtttg aatcgcct                            818


<210>  5426
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  5426

Met Asn Val Val Leu Ile Leu Ser Asn Ser Thr Lys Thr Ser Leu Leu 
1               5                   10                  15      


Gln Lys Phe Ala Leu Glu Val Tyr Thr Phe Thr Gly Ser Ser Cys Leu 
            20                  25                  30          


His Phe Ser Phe Leu Ser Leu Asp Lys His Arg Glu Trp Leu Glu Tyr 
        35                  40                  45              


Leu Leu Glu Phe Ala Gln Asp Ala Ala Pro Ile Pro Asn Gln Tyr Asp 
    50                  55                  60                  


Lys His Phe Met Glu Arg Asp Tyr Thr Gly Tyr Val Leu Ala Leu Asn 
65                  70                  75                  80  


Gly His Lys Lys Tyr Phe Cys Leu Phe Lys Pro Gln Lys Thr Val Glu 
                85                  90                  95      


Glu Glu Glu Ala Ile Gly Ser Cys Ser Asp Val Asp Ser Ser Leu Tyr 
            100                 105                 110         


Leu Gly Glu Ser Arg Gly Lys Pro Ser Cys Gly Leu Gly Ser Arg Pro 
        115                 120                 125             


Ile Lys Gly Lys Leu Ser Lys Leu Ser Leu Trp Met Glu Arg Leu Leu 
    130                 135                 140                 


Glu Gly Ser Leu Gln Arg Phe Tyr Ile Pro Ser Trp Pro Glu Leu Asp 
145                 150                 155                 160 


<210>  5427
<211>  1683
<212>  DNA
<213>  Homosapiens

<400>  5427
acggctttcc ccctatcctg acagcatctt aactcctcaa tatttctcca cagcaagatt     60

cctaaaaaag gctttgtgga ggtaactgaa ctcacagatg taacatacac cagtaacttg    120

gtacgtctga ggccaggcca catgaatgtg gtcctcatcc tgtcgaattc taccaagacc    180

agcctactac agaaatttgc tttggaggtc tacacattta ctgggagcag ctgcctacac    240

ttctccttcc tgagtctaga taaacacaga gaatggctag aatacttact agaatttgct    300

caagatgcag ctccaatccc aaaccaatat gataagcatt tcatggagcg tgactacact    360

ggttatgtac tggctctgaa tggccacaag aaatacttct gcctcttcaa gccccaaaag    420

acagtcgaag aggaggaagc catagggtcg tgcagtgatg ttgactcttc cctctacctg    480

ggtgaatctc gagggaaacc ttcctgtggc cttggatcca ggcccatcaa aggaaagttg    540

agcaagctct ctttatggat ggaacgcctg ctggagggct ccttacagag gttttatatc    600

ccatcatggc ctgaactaga ctgagaggat tttccaaaga gatttgaact cttcagactt    660

tttaacatgc ccctgtgaac aggtattttc aggactcaaa ctaccacaat gaacagagta    720

tagattttag attgctcttc tagaaccatg gctagaagaa tctttccttt gtcctgttct    780

aacctaggaa tgaaaaacac caccagtttg aatcgcctag atgaaaatct tttcctctgg    840

gtgttatttt tccccactga atgccacacc attgaaaata gactgctcat cccctcttcc    900

tttcttgtcc ttgtcccatg ctcaccccac cctcctgtcc tgtgtcttgg agaagcacag    960

ggctccaccc tgcaagcggc atctggcgga ccctcatgag cctgtcgtgc aggccaggtc   1020

attggcccct tccccaatcc cggccctgct gtgctgctgc catggcgcat gctcctaact   1080

ctgaacaacc cacggcagct tctagccccg catctggaaa aaggcccctt tccaagcaat   1140

ctcacgttta ctggttgttc tgggagtaag tggctaaatg tatattttgg gggtatcccc   1200

caacaacagt ttgttggcca caggttgaaa aggaaaggaa taaacgggag ttctgcatgt   1260

gagttctcaa gaaaaggaaa gggaggctga gcagtggctg aagcgatgca gccttgagac   1320

acgctgtgag catcccatcc gccgccccag cgctgctggt agccagggga ggggtctgca   1380

cagcgagaag tactgtgatg actttgagcc gttgacatgt atgtcttcag atgcctttct   1440

gcctctgtcg attttagggt atggatatta ggagccataa cttgtaatct tgttctctga   1500

acgtagagat aagctgctat aaagccagta gatgttaaac tgaagagaaa ttattcccac   1560

ctgctatgag tcaggcttaa ggaatctctt caatagtgtc tctttagtaa aataccaaac   1620

atgtctttgt atcaaggaac ttaaaatttc tcaacaattg tattttgaac actgttaccc   1680

taa                                                                 1683


<210>  5428
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  5428

Met Asn Val Val Leu Ile Leu Ser Asn Ser Thr Lys Thr Ser Leu Leu 
1               5                   10                  15      


Gln Lys Phe Ala Leu Glu Val Tyr Thr Phe Thr Gly Ser Ser Cys Leu 
            20                  25                  30          


His Phe Ser Phe Leu Ser Leu Asp Lys His Arg Glu Trp Leu Glu Tyr 
        35                  40                  45              


Leu Leu Glu Phe Ala Gln Asp Ala Ala Pro Ile Pro Asn Gln Tyr Asp 
    50                  55                  60                  


Lys His Phe Met Glu Arg Asp Tyr Thr Gly Tyr Val Leu Ala Leu Asn 
65                  70                  75                  80  


Gly His Lys Lys Tyr Phe Cys Leu Phe Lys Pro Gln Lys Thr Val Glu 
                85                  90                  95      


Glu Glu Glu Ala Ile Gly Ser Cys Ser Asp Val Asp Ser Ser Leu Tyr 
            100                 105                 110         


Leu Gly Glu Ser Arg Gly Lys Pro Ser Cys Gly Leu Gly Ser Arg Pro 
        115                 120                 125             


Ile Lys Gly Lys Leu Ser Lys Leu Ser Leu Trp Met Glu Arg Leu Leu 
    130                 135                 140                 


Glu Gly Ser Leu Gln Arg Phe Tyr Ile Pro Ser Trp Pro Glu Leu Asp 
145                 150                 155                 160 


<210>  5429
<211>  2538
<212>  DNA
<213>  Homosapiens

<400>  5429
ggagcagctg cctacacttc tccttcctga gtctagataa acacagagaa tggctagaat     60

acttactaga atttgctcaa gatgcagctc caatcccaaa ccaatatgat aagcatttca    120

tggagcgtga ctacactggt tatgtactgg ctctgaatgg ccacaagaaa tacttctgcc    180

tcttcaagcc ccaaaagaca gtcgaagagg aggaagccat agggtcgtgc agtgatgttg    240

actcttccct ctacctgggt gaatctcgag ggaaaccttc ctgtggcctt ggatccaggc    300

ccatcaaagg aaagttgagc aagctctctt tatggatgga acgcctgctg gagggctcct    360

tacagaggtt ttatatccca tcatggcctg aactagactg agaggatttt ccaaagagat    420

ttgaactctt cagacttttt aacatgcccc tgtgaacagt tgttgagaca gagtttcact    480

cttgttgccc aggctggagt gaaatggtgc gatctcggtt caccgcaacc tccacatccc    540

aggttcaagt gattctcctg cctcagcctc ctgagtagct aggattacag gcatgtgcca    600

ccatgtaatt agcccggcta attttgtatt tttagtagag acgggatttc tccatgttga    660

tcaggctggt catgaactcc tgacctcagg tgatctgcct gcctcagcct cccaaagtgc    720

tgctgggatt acaggcgtga gccaccactc ccggctaagt tagtatttct ttaatcttaa    780

tgctttaaac taagccactt ggatcctgaa taatttaaat cttgagctac attggtaagt    840

aataaattat ttaaggccag gaattcctgt agttttcatg gagtctgtag ctttattaaa    900

aaataaatca ctgccaggct tcattcttcc atatgatcct ctaaaaatgg acacttcctc    960

tgaatgctgt atctcatggc acctggtcca actagaaatg gtcaaggaat tcatttggct   1020

ccttgataca tcagtcctca atattacttt ctaggtattt tatggccaga ttgcttatat   1080

gagtggtctt ttggtttggt agtaggtttt tatttttaat ttctgtacta atgaaattcc   1140

tgactttaat ttctgaaaac caaaaactct ccaagtgtat ttatttatat tttttttaat   1200

agagacgagg tcttgctatg ttgcccaggc tggtcccaaa ctcctggcct caagcagtcc   1260

ttccaccttg gcctcccaaa gtgctgggat tatcaatatg agccaccatg ccagatttgt   1320

tcatttttaa acatttttat ctcttcaagt catcttttga tcttttaaaa agcaccttca   1380

aacagctgca ccttccattt gcactaggaa atgaaggtag tgatgggatt ggcaatgttc   1440

ctggcagatg tttcagccca aaagctcttc tacagaccgg tttagagctg gtgccctatg   1500

agaatattag ggagctttta ttttaaattg aactttaccc ttgtccatgc aaggcattcc   1560

tcctgaatgc atccatgaat ttgtttactt ttgcgtcaaa catatgagcc attgtcatgc   1620

tcagcctgtg ccaccattgc tctgtctgat gtatgtaatc atacaagacc tgattttggt   1680

tctaacacag tggtctttga ctatcaacat tgatgttttt agagatgggt tcttctggtt   1740

gatacagact atgcattgcg tttagcagat ggggtaaaac tggcctaaaa caagtctttg   1800

cagaatacat gccaatttcc aaaaaaaaaa aaaaatttgt tgctcaggtg ttgcacaatt   1860

tttatctaac actgaggcta tcagctccaa ctaaacaaca tttcagtggg tgaggctgcc   1920

ctaacttcca ttaggggcca tggtctcact gccatcactt attagccatg agaatttggt   1980

tgtagttttc aggtaggttg gtttcttcct catttgcagc ttgttgatac ttgttccttt   2040

ttatttatta acatcccaat caatttgcag ctgccatcat tacataaata tttttctgtt   2100

ataaaaagaa gtgtgatctg tttttttagt gatttccttt gtttgggaat agagattgga   2160

agcacatact cagacctgtt ttgttaacta gaattcttta aaagctgatg ccaaacatct   2220

ttacagagga actgtagttc acatccacct gtctgacatt gtcccctaaa aacaagtgca   2280

gtgtggcagc tgctgaatct gtctgttcag tttgtcaagg aggataatta tgcttgggag   2340

agatctgaaa agaaggtgaa tattttgcac ttttgatact cttaggaaca aataacttat   2400

ttggcaaatt gtttcttttt tatgttttgg gtgttgtttt tgttttttga ctttttttgt   2460

attgtgaaca ggcactgaag ctgatgttat tttaagatta cagaatggaa aaagaaataa   2520

actattttaa tgtctgat                                                 2538


<210>  5430
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  5430

Met Glu Arg Asp Tyr Thr Gly Tyr Val Leu Ala Leu Asn Gly His Lys 
1               5                   10                  15      


Lys Tyr Phe Cys Leu Phe Lys Pro Gln Lys Thr Val Glu Glu Glu Glu 
            20                  25                  30          


Ala Ile Gly Ser Cys Ser Asp Val Asp Ser Ser Leu Tyr Leu Gly Glu 
        35                  40                  45              


Ser Arg Gly Lys Pro Ser Cys Gly Leu Gly Ser Arg Pro Ile Lys Gly 
    50                  55                  60                  


Lys Leu Ser Lys Leu Ser Leu Trp Met Glu Arg Leu Leu Glu Gly Ser 
65                  70                  75                  80  


Leu Gln Arg Phe Tyr Ile Pro Ser Trp Pro Glu Leu Asp 
                85                  90              


<210>  5431
<211>  2930
<212>  DNA
<213>  Homosapiens

<400>  5431
ggagcagctg cctacacttc tccttcctga gtctagataa acacagagaa tggctagaat     60

acttactaga atttgctcaa gatgcagctc caatcccaaa ccaatatgat aagcatttca    120

tggagcgtga ctacactggt tatgtactgg ctctgaatgg ccacaagaaa tacttctgcc    180

tcttcaagcc ccaaaagaca gtcgaagagg aggaagccat agggtcgtgc agtgatgttg    240

actcttccct ctacctgggt gaatctcgag ggaaaccttc ctgtggcctt ggatccaggc    300

ccatcaaagg aaagttgagc aagctctctt tatggatgga acgcctgctg gagggctcct    360

tacagaggtt ttatatccca tcatggcctg aactagactg agaggatttt ccaaagagat    420

ttgaactctt cagacttttt aacatgcccc tgtgaacagt tgttgagaca gagtttcact    480

cttgttgccc aggctggagt gaaatggtgc gatctcggtt caccgcaacc tccacatccc    540

aggttcaagt gattctcctg cctcagcctc ctgagtagct aggattacag gcatgtgcca    600

ccatgtaatt agcccggcta attttgtatt tttagtagag acgggatttc tccatgttga    660

tcaggctggt catgaactcc tgacctcagg tgatctgcct gcctcagcct cccaaagtgc    720

tgctgggatt acaggcgtga gccaccactc ccggctaagt tagtatttct ttaatcttaa    780

tgctttaaac taagccactt ggatcctgaa taatttaaat cttgagctac attggtaagt    840

aataaattat ttaaggccag gaattcctgt agttttcatg gagtctgtag ctttattaaa    900

aaataaatca ctgccaggct tcattcttcc atatgatcct ctaaaaatgg acacttcctc    960

tgaatgctgt atctcatggc acctggtcca actagaaatg gtcaaggaat tcatttggct   1020

ccttgataca tcagtcctca atattacttt ctaggtattt tatggccaga ttgcttatat   1080

gagtggtctt ttggtttggt agtaggtttt tatttttaat ttctgtacta atgaaattcc   1140

tgactttaat ttctgaaaac caaaaactct ccaagtgtat ttatttatat tttttttaat   1200

agagacgagg tcttgctatg ttgcccaggc tggtcccaaa ctcctggcct caagcagtcc   1260

ttccaccttg gcctcccaaa gtgctgggat tatcaatatg agccaccatg ccagatttgt   1320

tcatttttaa acatttttat ctcttcaagt catcttttga tcttttaaaa agcaccttca   1380

aacagctgca ccttccattt gcactaggaa atgaaggtag tgatgggatt ggcaatgttc   1440

ctggcagatg tttcagccca aaagctcttc tacagaccgg tttagagctg gtgccctatg   1500

agaatattag ggagctttta ttttaaattg aactttaccc ttgtccatgc aaggcattcc   1560

tcctgaatgc atccatgaat ttgtttactt ttgcgtcaaa catatgagcc attgtcatgc   1620

tcagcctgtg ccaccattgc tctgtctgat gtatgtaatc atacaagacc tgattttggt   1680

tctaacacag tggtctttga ctatcaacat tgatgttttt agagatgggt tcttctggtt   1740

gatacagact atgcattgcg tttagcagat ggggtaaaac tggcctaaaa caagtctttg   1800

cagaatacat gccaatttcc aaaaaaaaaa aaaaatttgt tgctcaggtg ttgcacaatt   1860

tttatctaac actgaggcta tcagctccaa ctaaacaaca tttcagtggg tgaggctgcc   1920

ctaacttcca ttaggggcca tggtctcact gccatcactt attagccatg agaatttggt   1980

tgtagttttc aggtaggttg gtttcttcct catttgcagc ttgttgatac ttgttccttt   2040

ttatttatta acatcccaat caatttgcag ctgccatcat tacataaata tttttctgtt   2100

ataaaaagaa gtgtgatctg tttttttagt gatttccttt gtttgggaat agagattgga   2160

agcacatact cagacctgtt ttgttaacta gaattcttta aaagctgatg ccaaacatct   2220

ttacagagga actgtagttc acatccacct gtctgacatt gtcccctaaa aacaagtgca   2280

gtgtggcagc tgctgaatct gtctgttcag tttgtcaagg aggataatta tgcttgggag   2340

agatctgaaa agaaggtgaa tattttgcac ttttgatact cttaggaaca aataacttat   2400

ttggcaaatt gtttcttttt tatgttttgg gtgttgtttt tgttttttga ctttttttgt   2460

attgtgaaca ggcactgaag ctgatgttat tttaagatta cagaatggaa aaagaaataa   2520

actattttaa tgtctgataa ttatggggta gcccttgcat tgcaagatga tgatttgatt   2580

atggacacat tatcaacaga attgaatttg catggaactc aagacacgct taagatcacc   2640

acagcataac tgcagatttc aggaattaca gtcatagagg gtacatcaac ttgaagagta   2700

gattgagtct tacaggaagt gagttacaat aagtaacatt aagagcccag ctgccagcct   2760

ggccaacatg gtgaaacccc gtctctacta aaaatacaaa aattagccgg gcgtggtgac   2820

gcatgactgt aattctagct actcaggagg ctgaggcagc agaattgctt gaacccagga   2880

ggcggagatt gcagtgagct aagatcgggc cactgcactc cagcctgggg              2930


<210>  5432
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  5432

Met Glu Arg Asp Tyr Thr Gly Tyr Val Leu Ala Leu Asn Gly His Lys 
1               5                   10                  15      


Lys Tyr Phe Cys Leu Phe Lys Pro Gln Lys Thr Val Glu Glu Glu Glu 
            20                  25                  30          


Ala Ile Gly Ser Cys Ser Asp Val Asp Ser Ser Leu Tyr Leu Gly Glu 
        35                  40                  45              


Ser Arg Gly Lys Pro Ser Cys Gly Leu Gly Ser Arg Pro Ile Lys Gly 
    50                  55                  60                  


Lys Leu Ser Lys Leu Ser Leu Trp Met Glu Arg Leu Leu Glu Gly Ser 
65                  70                  75                  80  


Leu Gln Arg Phe Tyr Ile Pro Ser Trp Pro Glu Leu Asp 
                85                  90              


<210>  5433
<211>  2545
<212>  DNA
<213>  Homosapiens

<400>  5433
agttagctgg gcgtggtggc gcgtgcctat agtcccagct actcaggaag ctgaggcagg     60

ggcattgctt gaacccggga ggtggaggtt gcagtgagct gaggtcatgc cactacactc    120

cagcctgggt gacagagtga gactccgtct ccaaaaaaaa aaaaaaaaaa aaaaaagcag    180

gccggaccca gtggctcacg cctgtaatcc caggcctagg cgggaggatc accatgttgg    240

ccaggctggc agctgggctc ttaatgttac ttattgtaac tcacttcctg taagactcaa    300

tctactcttc aagttgatgt accctctatg actgtaattc ctgaaatctg cagttatgct    360

gtggtgatct taagcgtgtc ttgagttcca tgcaaattca attctgttga taatgtgtcc    420

ataatcaaat catcatcttg caatgcaagg gctaccccat aattatcaga cattaaaata    480

gtttatttct ttttccattc tgtaatctta aaataacatc agcttcagtg cctgttcaca    540

atacaaaaaa agtcaaaaaa caaaaacaac acccaaaaca taaaaaagaa acaatttgcc    600

aaataagtta tttgttccta agagtatcaa aagtgcaaaa tattcacctt cttttcagat    660

ctctcccaag cataattatc ctccttgaca aactgaacag acagattcag cagctgccac    720

actgcacttg tttttagggg acaatgtcag acaggtggat gtgaactaca gttcctctgt    780

aaagatgttt ggcatcagct tttaaagaat tctagttaac aaaacaggtc tgagtatgtg    840

cttccaatct ctattcccaa acaaaggaaa tcactaaaaa aacagatcac acttcttttt    900

ataacagaaa aatatttatg taatgatggc agctgcaaat tgattgggat gttaataaat    960

aaaaaggaac aagtatcaac aagctgcaaa tgaggaagaa accaacctac ctgaaaacta   1020

caaccaaatt ctcatggcta ataagtgatg gcagtgagac catggcccct aatggaagtt   1080

agggcagcct cacccactga aatgttgttt agttggagct gatagcctca gtgttagata   1140

aaaattgtgc aacacctgag caacaaattt tttttttttt ttggaaattg gcatgtattc   1200

tgcaaagact tgttttaggc cagttttacc ccatctgcta aacgcaatgc atagtctgta   1260

tcaaccagaa gaacccatct ctaaaaacat caatgttgat agtcaaagac cactgtgtta   1320

gaaccaaaat caggtcttgt atgattacat acatcagaca gagcaatggt ggcacaggct   1380

gagcatgaca atggctcata tgtttgacgc aaaagtaaac aaattcatgg atgcattcag   1440

gaggaatgcc ttgcatggac aagggtaaag ttcaatttaa aataaaagct ccctaatatt   1500

ctcatagggc accagctcta aaccggtctg tagaagagct tttgggctga aacatctgcc   1560

aggaacattg ccaatcccat cactaccttc atttcctagt gcaaatggaa ggtgcagctg   1620

tttgaaggtg ctttttaaaa gatcaaaaga tgacttgaag agataaaaat gtttaaaaat   1680

gaacaaatct ggcatggtgg ctcatattga taatcccagc actttgggag gccaaggtgg   1740

aaggactgct tgaggccagg agtttgggac cagcctgggc aacatagcaa gacctcgtct   1800

ctattaaaaa aaatataaat aaatacactt ggagagtttt tggttttcag aaattaaagt   1860

caggaatttc attagtacag aaattaaaaa taaaaaccta ctaccaaacc aaaagaccac   1920

tcatataagc aatctggcca taaaatacct agaaagtaat attgaggact gatgtatcaa   1980

ggagccaaat gaattccttg accatttcta gttggaccag gtgccatgag atacagcatt   2040

cagaggaagt gtccattttt agaggatcat atggaagaat gaagcctggc agtgatttat   2100

tttttaataa agctacagac tccatgaaaa ctacaggaat tcctggcctt aaataattta   2160

ttacttacca atgtagctca agatttaaat tattcaggat ccaagtggct tagtttaaag   2220

cattaagatt aaagaaatac taacttagcc gggagtggtg gctcacgcct gtaatcccag   2280

cagcactttg ggaggctgag gcaggcagat cacctgaggt caggagttca tgaccagcct   2340

gatcaacatg gagaaatccc gtctctacta aaaatacaaa attagccggg ctaattacat   2400

ggtggcacat gcctgtaatc ctagctactc aggaggctga ggcaggagaa tcacttgaac   2460

ctgggatgtg gaggttgcgg tgaaccgaga tcgcaccatt tcactccagc ctgggcaaca   2520

agagtgaaac tctgtctcaa caact                                         2545


<210>  5434
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  5434

Met Pro Leu His Ser Ser Leu Gly Asp Arg Val Arg Leu Arg Leu Gln 
1               5                   10                  15      


Lys Lys Lys Lys Lys Lys Lys Ser Arg Pro Asp Pro Val Ala His Ala 
            20                  25                  30          


Cys Asn Pro Arg Pro Arg Arg Glu Asp His His Val Gly Gln Ala Gly 
        35                  40                  45              


Ser Trp Ala Leu Asn Val Thr Tyr Cys Asn Ser Leu Pro Val Arg Leu 
    50                  55                  60                  


Asn Leu Leu Phe Lys Leu Met Tyr Pro Leu 
65                  70                  


<210>  5435
<211>  2437
<212>  DNA
<213>  Homosapiens

<400>  5435
cactccagcc tgggtgccag agcaagactc catctcaaaa aaaaaaaaaa aaaatacaga     60

aaaaaaaagc aggccggacc cagtggctca cgcctgtaat cccaggccta ggcgggagga    120

tcaccatgtt ggccaggctg gcagctgggc tcttaatgtt acttattgta actcacttcc    180

tgtaagactc aatctactct tcaagttgat gtaccctcta tgactgtaat tcctgaaatc    240

tgcagttatg ctgtggtgat cttaagcgtg tcttgagttc catgcaaatt caattctgtt    300

gataatgtgt ccataatcaa atcatcatct tgcaatgcaa gggctacccc ataattatca    360

gacattaaaa tagtttattt ctttttccat tctgtaatct taaaataaca tcagcttcag    420

tgcctgttca caatacaaaa aaagtcaaaa aacaaaaaca acacccaaaa cataaaaaag    480

aaacaatttg ccaaataagt tatttgttcc taagagtatc aaaagtgcaa aatattcacc    540

ttcttttcag atctctccca agcataatta tcctccttga caaactgaac agacagattc    600

agcagctgcc acactgcact tgtttttagg ggacaatgtc agacaggtgg atgtgaacta    660

cagttcctct gtaaagatgt ttggcatcag cttttaaaga attctagtta acaaaacagg    720

tctgagtatg tgcttccaat ctctattccc aaacaaagga aatcactaaa aaaacagatc    780

acacttcttt ttataacaga aaaatattta tgtaatgatg gcagctgcaa attgattggg    840

atgttaataa ataaaaagga acaagtatca acaagctgca aatgaggaag aaaccaacct    900

acctgaaaac tacaaccaaa ttctcatggc taataagtga tggcagtgag accatggccc    960

ctaatggaag ttagggcagc ctcacccact gaaatgttgt ttagttggag ctgatagcct   1020

cagtgttaga taaaaattgt gcaacacctg agcaacaaat tttttttttt ttttggaaat   1080

tggcatgtat tctgcaaaga cttgttttag gccagtttta ccccatctgc taaacgcaat   1140

gcatagtctg tatcaaccag aagaacccat ctctaaaaac atcaatgttg atagtcaaag   1200

accactgtgt tagaaccaaa atcaggtctt gtatgattac atacatcaga cagagcaatg   1260

gtggcacagg ctgagcatga caatggctca tatgtttgac gcaaaagtaa acaaattcat   1320

ggatgcattc aggaggaatg ccttgcatgg acaagggtaa agttcaattt aaaataaaag   1380

ctccctaata ttctcatagg gcaccagctc taaaccggtc tgtagaagag cttttgggct   1440

gaaacatctg ccaggaacat tgccaatccc atcactacct tcatttccta gtgcaaatgg   1500

aaggtgcagc tgtttgaagg tgctttttaa aagatcaaaa gatgacttga agagataaaa   1560

atgtttaaaa atgaacaaat ctggcatggt ggctcatatt gataatccca gcactttggg   1620

aggccaaggt ggaaggactg cttgaggcca ggagtttggg accagcctgg gcaacatagc   1680

aagacctcgt ctctattaaa aaaaatataa ataaatacac ttggagagtt tttggttttc   1740

agaaattaaa gtcaggaatt tcattagtac agaaattaaa aataaaaacc tactaccaaa   1800

ccaaaagacc actcatataa gcaatctggc cataaaatac ctagaaagta atattgagga   1860

ctgatgtatc aaggagccaa atgaattcct tgaccatttc tagttggacc aggtgccatg   1920

agatacagca ttcagaggaa gtgtccattt ttagaggatc atatggaaga atgaagcctg   1980

gcagtgattt attttttaat aaagctacag actccatgaa aactacagga attcctggcc   2040

ttaaataatt tattacttac caatgtagct caagatttaa attattcagg atccaagtgg   2100

cttagtttaa agcattaaga ttaaagaaat actaacttag ccgggagtgg tggctcacgc   2160

ctgtaatccc agcagcactt tgggaggctg aggcaggcag atcacctgag gtcaggagtt   2220

catgaccagc ctgatcaaca tggagaaatc ccgtctctac taaaaataca aaattagccg   2280

ggctaattac atggtggcac atgcctgtaa tcctagctac tcaggaggct gaggcaggag   2340

aatcacttga acctgggatg tggaggttgc ggtgaaccga gatcgcacca tttcactcca   2400

gcctgggcaa caagagtgaa actctgtctc aacaact                            2437


<210>  5436
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  5436

Met Asn Ser Leu Thr Ile Ser Ser Trp Thr Arg Cys His Glu Ile Gln 
1               5                   10                  15      


His Ser Glu Glu Val Ser Ile Phe Arg Gly Ser Tyr Gly Arg Met Lys 
            20                  25                  30          


Pro Gly Ser Asp Leu Phe Phe Asn Lys Ala Thr Asp Ser Met Lys Thr 
        35                  40                  45              


Thr Gly Ile Pro Gly Leu Lys 
    50                  55  


<210>  5437
<211>  2659
<212>  DNA
<213>  Homosapiens

<400>  5437
agtattgagt atcttccttt aaactacagc tcctcctcgg acgctgcagt gagctgagat     60

cgcaccactg cactccagcc tgggtgccag agcaagactc catctcaaaa aaaaaaaaaa    120

aaaatacagc ttctcctatg aggtgcttag ggctgcatct tggttttagg accactgtga    180

acgtaagtaa aaagtataaa gtaacacgga gagcctaatg aagaaacttc ttgctcagag    240

gcctagaagg gtacacaaaa tgtcttctaa actagaaaac ctaaggctgg acacggtggc    300

tcatgcctgt aatcccagca ctttgggggg cggaggtggg cagatcactt gaggtcaggc    360

tggcagctgg gctcttaatg ttacttattg taactcactt cctgtaagac tcaatctact    420

cttcaagttg atgtaccctc tatgactgta attcctgaaa tctgcagtta tgctgtggtg    480

atcttaagcg tgtcttgagt tccatgcaaa ttcaattctg ttgataatgt gtccataatc    540

aaatcatcat cttgcaatgc aagggctacc ccataattat cagacattaa aatagtttat    600

ttctttttcc attctgtaat cttaaaataa catcagcttc agtgcctgtt cacaatacaa    660

aaaaagtcaa aaaacaaaaa caacacccaa aacataaaaa agaaacaatt tgccaaataa    720

gttatttgtt cctaagagta tcaaaagtgc aaaatattca ccttcttttc agatctctcc    780

caagcataat tatcctcctt gacaaactga acagacagat tcagcagctg ccacactgca    840

cttgttttta ggggacaatg tcagacaggt ggatgtgaac tacagttcct ctgtaaagat    900

gtttggcatc agcttttaaa gaattctagt taacaaaaca ggtctgagta tgtgcttcca    960

atctctattc ccaaacaaag gaaatcacta aaaaaacaga tcacacttct ttttataaca   1020

gaaaaatatt tatgtaatga tggcagctgc aaattgattg ggatgttaat aaataaaaag   1080

gaacaagtat caacaagctg caaatgagga agaaaccaac ctacctgaaa actacaacca   1140

aattctcatg gctaataagt gatggcagtg agaccatggc ccctaatgga agttagggca   1200

gcctcaccca ctgaaatgtt gtttagttgg agctgatagc ctcagtgtta gataaaaatt   1260

gtgcaacacc tgagcaacaa attttttttt ttttttggaa attggcatgt attctgcaaa   1320

gacttgtttt aggccagttt taccccatct gctaaacgca atgcatagtc tgtatcaacc   1380

agaagaaccc atctctaaaa acatcaatgt tgatagtcaa agaccactgt gttagaacca   1440

aaatcaggtc ttgtatgatt acatacatca gacagagcaa tggtggcaca ggctgagcat   1500

gacaatggct catatgtttg acgcaaaagt aaacaaattc atggatgcat tcaggaggaa   1560

tgccttgcat ggacaagggt aaagttcaat ttaaaataaa agctccctaa tattctcata   1620

gggcaccagc tctaaaccgg tctgtagaag agcttttggg ctgaaacatc tgccaggaac   1680

attgccaatc ccatcactac cttcatttcc tagtgcaaat ggaaggtgca gctgtttgaa   1740

ggtgcttttt aaaagatcaa aagatgactt gaagagataa aaatgtttaa aaatgaacaa   1800

atctggcatg gtggctcata ttgataatcc cagcactttg ggaggccaag gtggaaggac   1860

tgcttgaggc caggagtttg ggaccagcct gggcaacata gcaagacctc gtctctatta   1920

aaaaaaatat aaataaatac acttggagag tttttggttt tcagaaatta aagtcaggaa   1980

tttcattagt acagaaatta aaaataaaaa cctactacca aaccaaaaga ccactcatat   2040

aagcaatctg gccataaaat acctagaaag taatattgag gactgatgta tcaaggagcc   2100

aaatgaattc cttgaccatt tctagttgga ccaggtgcca tgagatacag cattcagagg   2160

aagtgtccat ttttagagga tcatatggaa gaatgaagcc tggcagtgat ttatttttta   2220

ataaagctac agactccatg aaaactacag gaattcctgg ccttaaataa tttattactt   2280

accaatgtag ctcaagattt aaattattca ggatccaagt ggcttagttt aaagcattaa   2340

gattaaagaa atactaactt agccgggagt ggtggctcac gcctgtaatc ccagcagcac   2400

tttgggaggc tgaggcaggc agatcacctg aggtcaggag ttcatgacca gcctgatcaa   2460

catggagaaa tcccgtctct actaaaaata caaaattagc cgggctaatt acatggtggc   2520

acatgcctgt aatcctagct actcaggagg ctgaggcagg agaatcactt gaacctggga   2580

tgtggaggtt gcggtgaacc gagatcgcac catttcactc cagcctgggc aacaagagtg   2640

aaactctgtc tcaacaact                                                2659


<210>  5438
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  5438

Met Pro Val Ile Pro Ala Leu Trp Gly Ala Glu Val Gly Arg Ser Leu 
1               5                   10                  15      


Glu Val Arg Leu Ala Ala Gly Leu Leu Met Leu Leu Ile Val Thr His 
            20                  25                  30          


Phe Leu 
        


<210>  5439
<211>  2465
<212>  DNA
<213>  Homosapiens

<400>  5439
agtattgagt atcttccttt aaactacagc tcctcctcgg acgctgcagt gagctgagat     60

cgcaccactg cactccagcc tgggtgccag agcaagactc catctcaaaa aaaaaaaaaa    120

aaaatacagc ttctcctatg aggtgcttag ggctgcatct tggttttagg accactgtga    180

acgtaagtaa aaagtataaa gtaacacgga gagcctaatg aagaaacttc ttgctcagag    240

gccctctatg actgtaattc ctgaaatctg cagttatgct gtggtgatct taagcgtgtc    300

ttgagttcca tgcaaattca attctgttga taatgtgtcc ataatcaaat catcatcttg    360

caatgcaagg gctaccccat aattatcaga cattaaaata gtttatttct ttttccattc    420

tgtaatctta aaataacatc agcttcagtg cctgttcaca atacaaaaaa agtcaaaaaa    480

caaaaacaac acccaaaaca taaaaaagaa acaatttgcc aaataagtta tttgttccta    540

agagtatcaa aagtgcaaaa tattcacctt cttttcagat ctctcccaag cataattatc    600

ctccttgaca aactgaacag acagattcag cagctgccac actgcacttg tttttagggg    660

acaatgtcag acaggtggat gtgaactaca gttcctctgt aaagatgttt ggcatcagct    720

tttaaagaat tctagttaac aaaacaggtc tgagtatgtg cttccaatct ctattcccaa    780

acaaaggaaa tcactaaaaa aacagatcac acttcttttt ataacagaaa aatatttatg    840

taatgatggc agctgcaaat tgattgggat gttaataaat aaaaaggaac aagtatcaac    900

aagctgcaaa tgaggaagaa accaacctac ctgaaaacta caaccaaatt ctcatggcta    960

ataagtgatg gcagtgagac catggcccct aatggaagtt agggcagcct cacccactga   1020

aatgttgttt agttggagct gatagcctca gtgttagata aaaattgtgc aacacctgag   1080

caacaaattt tttttttttt ttggaaattg gcatgtattc tgcaaagact tgttttaggc   1140

cagttttacc ccatctgcta aacgcaatgc atagtctgta tcaaccagaa gaacccatct   1200

ctaaaaacat caatgttgat agtcaaagac cactgtgtta gaaccaaaat caggtcttgt   1260

atgattacat acatcagaca gagcaatggt ggcacaggct gagcatgaca atggctcata   1320

tgtttgacgc aaaagtaaac aaattcatgg atgcattcag gaggaatgcc ttgcatggac   1380

aagggtaaag ttcaatttaa aataaaagct ccctaatatt ctcatagggc accagctcta   1440

aaccggtctg tagaagagct tttgggctga aacatctgcc aggaacattg ccaatcccat   1500

cactaccttc atttcctagt gcaaatggaa ggtgcagctg tttgaaggtg ctttttaaaa   1560

gatcaaaaga tgacttgaag agataaaaat gtttaaaaat gaacaaatct ggcatggtgg   1620

ctcatattga taatcccagc actttgggag gccaaggtgg aaggactgct tgaggccagg   1680

agtttgggac cagcctgggc aacatagcaa gacctcgtct ctattaaaaa aaatataaat   1740

aaatacactt ggagagtttt tggttttcag aaattaaagt caggaatttc attagtacag   1800

aaattaaaaa taaaaaccta ctaccaaacc aaaagaccac tcatataagc aatctggcca   1860

taaaatacct agaaagtaat attgaggact gatgtatcaa ggagccaaat gaattccttg   1920

accatttcta gttggaccag gtgccatgag atacagcatt cagaggaagt gtccattttt   1980

agaggatcat atggaagaat gaagcctggc agtgatttat tttttaataa agctacagac   2040

tccatgaaaa ctacaggaat tcctggcctt aaataattta ttacttacca atgtagctca   2100

agatttaaat tattcaggat ccaagtggct tagtttaaag cattaagatt aaagaaatac   2160

taacttagcc gggagtggtg gctcacgcct gtaatcccag cagcactttg ggaggctgag   2220

gcaggcagat cacctgaggt caggagttca tgaccagcct gatcaacatg gagaaatccc   2280

gtctctacta aaaatacaaa attagccggg ctaattacat ggtggcacat gcctgtaatc   2340

ctagctactc aggaggctga ggcaggagaa tcacttgaac ctgggatgtg gaggttgcgg   2400

tgaaccgaga tcgcaccatt tcactccagc ctgggcaaca agagtgaaac tctgtctcaa   2460

caact                                                               2465


<210>  5440
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  5440

Met Asn Ser Leu Thr Ile Ser Ser Trp Thr Arg Cys His Glu Ile Gln 
1               5                   10                  15      


His Ser Glu Glu Val Ser Ile Phe Arg Gly Ser Tyr Gly Arg Met Lys 
            20                  25                  30          


Pro Gly Ser Asp Leu Phe Phe Asn Lys Ala Thr Asp Ser Met Lys Thr 
        35                  40                  45              


Thr Gly Ile Pro Gly Leu Lys 
    50                  55  


<210>  5441
<211>  2448
<212>  DNA
<213>  Homosapiens

<400>  5441
agcctcctga gtacctggga ttacaggtgc ctgccaccac gcctggctaa tttttgtatt     60

tttagtagag acagggtttc accacattgg ccaggctggt cttgaactcc tgacctaagg    120

tgatccgccc gcctcagcct ccttaaagtg ctgggattac aggcatgagc caccgcaccc    180

agccgctttt taaaattttg atgatctgtc ttcaagttga tgtaccctct atgactgtaa    240

ttcctgaaat ctgcagttat gctgtggtga tcttaagcgt gtcttgagtt ccatgcaaat    300

tcaattctgt tgataatgtg tccataatca aatcatcatc ttgcaatgca agggctaccc    360

cataattatc agacattaaa atagtttatt tctttttcca ttctgtaatc ttaaaataac    420

atcagcttca gtgcctgttc acaatacaaa aaaagtcaaa aaacaaaaac aacacccaaa    480

acataaaaaa gaaacaattt gccaaataag ttatttgttc ctaagagtat caaaagtgca    540

aaatattcac cttcttttca gatctctccc aagcataatt atcctccttg acaaactgaa    600

cagacagatt cagcagctgc cacactgcac ttgtttttag gggacaatgt cagacaggtg    660

gatgtgaact acagttcctc tgtaaagatg tttggcatca gcttttaaag aattctagtt    720

aacaaaacag gtctgagtat gtgcttccaa tctctattcc caaacaaagg aaatcactaa    780

aaaaacagat cacacttctt tttataacag aaaaatattt atgtaatgat ggcagctgca    840

aattgattgg gatgttaata aataaaaagg aacaagtatc aacaagctgc aaatgaggaa    900

gaaaccaacc tacctgaaaa ctacaaccaa attctcatgg ctaataagtg atggcagtga    960

gaccatggcc cctaatggaa gttagggcag cctcacccac tgaaatgttg tttagttgga   1020

gctgatagcc tcagtgttag ataaaaattg tgcaacacct gagcaacaaa tttttttttt   1080

tttttggaaa ttggcatgta ttctgcaaag acttgtttta ggccagtttt accccatctg   1140

ctaaacgcaa tgcatagtct gtatcaacca gaagaaccca tctctaaaaa catcaatgtt   1200

gatagtcaaa gaccactgtg ttagaaccaa aatcaggtct tgtatgatta catacatcag   1260

acagagcaat ggtggcacag gctgagcatg acaatggctc atatgtttga cgcaaaagta   1320

aacaaattca tggatgcatt caggaggaat gccttgcatg gacaagggta aagttcaatt   1380

taaaataaaa gctccctaat attctcatag ggcaccagct ctaaaccggt ctgtagaaga   1440

gcttttgggc tgaaacatct gccaggaaca ttgccaatcc catcactacc ttcatttcct   1500

agtgcaaatg gaaggtgcag ctgtttgaag gtgcttttta aaagatcaaa agatgacttg   1560

aagagataaa aatgtttaaa aatgaacaaa tctggcatgg tggctcatat tgataatccc   1620

agcactttgg gaggccaagg tggaaggact gcttgaggcc aggagtttgg gaccagcctg   1680

ggcaacatag caagacctcg tctctattaa aaaaaatata aataaataca cttggagagt   1740

ttttggtttt cagaaattaa agtcaggaat ttcattagta cagaaattaa aaataaaaac   1800

ctactaccaa accaaaagac cactcatata agcaatctgg ccataaaata cctagaaagt   1860

aatattgagg actgatgtat caaggagcca aatgaattcc ttgaccattt ctagttggac   1920

caggtgccat gagatacagc attcagagga agtgtccatt tttagaggat catatggaag   1980

aatgaagcct ggcagtgatt tattttttaa taaagctaca gactccatga aaactacagg   2040

aattcctggc cttaaataat ttattactta ccaatgtagc tcaagattta aattattcag   2100

gatccaagtg gcttagttta aagcattaag attaaagaaa tactaactta gccgggagtg   2160

gtggctcacg cctgtaatcc cagcagcact ttgggaggct gaggcaggca gatcacctga   2220

ggtcaggagt tcatgaccag cctgatcaac atggagaaat cccgtctcta ctaaaaatac   2280

aaaattagcc gggctaatta catggtggca catgcctgta atcctagcta ctcaggaggc   2340

tgaggcagga gaatcacttg aacctgggat gtggaggttg cggtgaaccg agatcgcacc   2400

atttcactcc agcctgggca acaagagtga aactctgtct caacaact                2448


<210>  5442
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5442

Met Ser His Arg Thr Gln Pro Leu Phe Lys Ile Leu Met Ile Cys Leu 
1               5                   10                  15      


Gln Val Asp Val Pro Ser Met Thr Val Ile Pro Glu Ile Cys Ser Tyr 
            20                  25                  30          


Ala Val Val Ile Leu Ser Val Ser 
        35                  40  


<210>  5443
<211>  329
<212>  DNA
<213>  Homosapiens

<400>  5443
aaaaaaaaag caggccggac ccagtggctc acgcctgtaa tcccaggcct aggcgggagg     60

atcaccatgt tggccaggct ggcagctggg ctcttaatgt tacttattgt aactcacttc    120

ctgtaagact caatctactc ttcaagttga tgtaccctct atgactgtaa ttcctgaaat    180

ctgcagttat gctgtggtga tcttaagcgt gtcttgagtt ccatgcaaat tcaattctgt    240

tgataatgtg tccataatca aatcatcatc ttgcaatgca agggctaccc cataattatc    300

agacattaaa atagtttatt tctttttcc                                      329


<210>  5444
<211>  496
<212>  DNA
<213>  Homosapiens

<400>  5444
agttagctgg gcgtggtggc gcgtgcctat agtcccagct actcaggaag ctgaggcagg     60

ggcattgctt gaacccggga ggtggaggtt gcagtgagct gaggtcatgc cactacactc    120

cagcctgggt gacagagtga gactccgtct ccaaaaaaaa aaaaaaaaaa aaaaaagcag    180

gccggaccca gtggctcacg cctgtaatcc caggcctagg cgggaggatc accatgttgg    240

ccaggctggc agctgggctc ttaatgttac ttattgtaac tcacttcctg taagactcaa    300

tctactcttc aagttgatgt accctctatg actgtaattc ctgaaatctg cagttatgct    360

gtggtgatct taagcgtgtc ttgagttcca tgcaaattca attctgttga taatgtgtcc    420

ataatcaaat catcatcttg caatgcaagg gctaccccat aattatcaga cattaaaata    480

gtttatttct ttttcc                                                    496


<210>  5445
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  5445

Met Pro Leu His Ser Ser Leu Gly Asp Arg Val Arg Leu Arg Leu Gln 
1               5                   10                  15      


Lys Lys Lys Lys Lys Lys Lys Ser Arg Pro Asp Pro Val Ala His Ala 
            20                  25                  30          


Cys Asn Pro Arg Pro Arg Arg Glu Asp His His Val Gly Gln Ala Gly 
        35                  40                  45              


Ser Trp Ala Leu Asn Val Thr Tyr Cys Asn Ser Leu Pro Val Arg Leu 
    50                  55                  60                  


Asn Leu Leu Phe Lys Leu Met Tyr Pro Leu 
65                  70                  


<210>  5446
<211>  610
<212>  DNA
<213>  Homosapiens

<400>  5446
agtattgagt atcttccttt aaactacagc tcctcctcgg acgctgcagt gagctgagat     60

cgcaccactg cactccagcc tgggtgccag agcaagactc catctcaaaa aaaaaaaaaa    120

aaaatacagc ttctcctatg aggtgcttag ggctgcatct tggttttagg accactgtga    180

acgtaagtaa aaagtataaa gtaacacgga gagcctaatg aagaaacttc ttgctcagag    240

gcctagaagg gtacacaaaa tgtcttctaa actagaaaac ctaaggctgg acacggtggc    300

tcatgcctgt aatcccagca ctttgggggg cggaggtggg cagatcactt gaggtcaggc    360

tggcagctgg gctcttaatg ttacttattg taactcactt cctgtaagac tcaatctact    420

cttcaagttg atgtaccctc tatgactgta attcctgaaa tctgcagtta tgctgtggtg    480

atcttaagcg tgtcttgagt tccatgcaaa ttcaattctg ttgataatgt gtccataatc    540

aaatcatcat cttgcaatgc aagggctacc ccataattat cagacattaa aatagtttat    600

ttctttttcc                                                           610


<210>  5447
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  5447

Met Pro Val Ile Pro Ala Leu Trp Gly Ala Glu Val Gly Arg Ser Leu 
1               5                   10                  15      


Glu Val Arg Leu Ala Ala Gly Leu Leu Met Leu Leu Ile Val Thr His 
            20                  25                  30          


Phe Leu 
        


<210>  5448
<211>  1944
<212>  DNA
<213>  Homosapiens

<400>  5448
tgacctttga gccggctcgg gttccggctc tggcgcgtgc acactcgcct cgccgttcgg     60

gaccagccag atcgcggcgg cctcgcgggc ggtttggtcg gtgaggtctt ggccgcgcgc    120

ggcaatgctg aggctgctgg cgtccgggtg cgcccggggc ccggggcccg gcgtgggcgc    180

gcgtcctgcc gcagggctct ttcatccggg gcgccgccag agccgccagg cttccgacgc    240

gccccggaac cagcccccca gccccgagtt cgtggcccgg ccggtgggcg tctgctccat    300

gatgcgcctg ccggtgcaga cctcccccga ggggctggac gctgccttca tcggggtgcc    360

cctggatact gggacctcca accggcctgg ggcgagattc ggacctcgcc gcatccggga    420

agaatcagtg atgcttggga cagtcaatcc tagcacgggg gccctcccct tccagtccct    480

catggttgca gacctaggcg atgtgaatgt caatctttac aaccttcagg acagctgccg    540

gcgaattcaa gaggcctatg agaaaattgt agcagctggc tgtattcctc tgaccttggg    600

tggagatcac acaatcacat atcccatatt gcaagcgatg gcaaaaaagc atggcccagt    660

ggggctgctg cacgtggatg cgcacacgga cacgaccgac aaggccctag gagagaagct    720

ctaccacggg gcgcccttcc gccggtgtgt ggatgagggt ctcctggact gtaagcgtgt    780

ggtgcagatt ggcatccggg gctcttccac gaccttggat ccctacagat acaaccggag    840

ccagggcttc cgggtagtcc tggctgaaga ctgctggatg aagtcgctgg ttcctctgat    900

gggggaagtc aggcagcaga tgggaggcaa acccatttat atcagctttg atattgacgc    960

tctggatcct gcctatgcgc cagggacagg gacacctgaa attgctggtc tcactcctag   1020

tcaggctctg gagatcatca ggggttgtca aggcctgaac gtgatgggct gtgatcttgt   1080

cgaagtttca ccaccgtatg atctttctgg gaacacagcc ctgctggcgg ctaacctgct   1140

gtttgagatg ctatgtgctc tccccaaagt gacaaccgtc tgagtcttgt gctcttcaag   1200

acaaaacaga ttgcgtcgct gacaagttct caagaagaac ttatgagtaa gcagtctgag   1260

aactaaagag tttatgccaa gaaaactttc tgctgaaagt gtcattgctg gctgtgaagt   1320

cgggataatc agtagaattc tcacccaaac agcaacattt ctaaggaact tggattaatt   1380

gggggaaaaa aaaaggagta cttgtactgc tttgattttt tttcctttga tgaaagatgg   1440

aggataaagg ggaagtgagg agaatttctt tcaagattat ctaaacatta gaaacatgac   1500

atttaaaaaa actatgaaat aatactgtat aagcattcca tatttctata tcttcctttt   1560

aaacattttt ttttttgaga tagagttttg cttgtcaccc aggctggagt gcaatggcat   1620

gatctcggtt cattgcaacc tccgcctccc gagttcaatc gattctcctg cctcagcctg   1680

taatcccagc actttggggg gcggaggtgg gcagatcact tgaggtcagg agttcgagac   1740

cagcctggcc aacatggtga aaacccatct ctactgaaaa tacagaagtt agctgggcgt   1800

ggtggcgcgt gcctatagtc ccagctactc aggaagctga ggcaggggca ttgcttgaac   1860

ccgggaggtg gaggttgcag tgagctgagg tcatgccact acactccagc ctgggtgaca   1920

gagtgagact ccgtctccaa aaaa                                          1944


<210>  5449
<211>  352
<212>  PRT
<213>  Homosapiens

<400>  5449

Met Leu Arg Leu Leu Ala Ser Gly Cys Ala Arg Gly Pro Gly Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Pro Ala Ala Gly Leu Phe His Pro Gly Arg Arg Gln 
            20                  25                  30          


Ser Arg Gln Ala Ser Asp Ala Pro Arg Asn Gln Pro Pro Ser Pro Glu 
        35                  40                  45              


Phe Val Ala Arg Pro Val Gly Val Cys Ser Met Met Arg Leu Pro Val 
    50                  55                  60                  


Gln Thr Ser Pro Glu Gly Leu Asp Ala Ala Phe Ile Gly Val Pro Leu 
65                  70                  75                  80  


Asp Thr Gly Thr Ser Asn Arg Pro Gly Ala Arg Phe Gly Pro Arg Arg 
                85                  90                  95      


Ile Arg Glu Glu Ser Val Met Leu Gly Thr Val Asn Pro Ser Thr Gly 
            100                 105                 110         


Ala Leu Pro Phe Gln Ser Leu Met Val Ala Asp Leu Gly Asp Val Asn 
        115                 120                 125             


Val Asn Leu Tyr Asn Leu Gln Asp Ser Cys Arg Arg Ile Gln Glu Ala 
    130                 135                 140                 


Tyr Glu Lys Ile Val Ala Ala Gly Cys Ile Pro Leu Thr Leu Gly Gly 
145                 150                 155                 160 


Asp His Thr Ile Thr Tyr Pro Ile Leu Gln Ala Met Ala Lys Lys His 
                165                 170                 175     


Gly Pro Val Gly Leu Leu His Val Asp Ala His Thr Asp Thr Thr Asp 
            180                 185                 190         


Lys Ala Leu Gly Glu Lys Leu Tyr His Gly Ala Pro Phe Arg Arg Cys 
        195                 200                 205             


Val Asp Glu Gly Leu Leu Asp Cys Lys Arg Val Val Gln Ile Gly Ile 
    210                 215                 220                 


Arg Gly Ser Ser Thr Thr Leu Asp Pro Tyr Arg Tyr Asn Arg Ser Gln 
225                 230                 235                 240 


Gly Phe Arg Val Val Leu Ala Glu Asp Cys Trp Met Lys Ser Leu Val 
                245                 250                 255     


Pro Leu Met Gly Glu Val Arg Gln Gln Met Gly Gly Lys Pro Ile Tyr 
            260                 265                 270         


Ile Ser Phe Asp Ile Asp Ala Leu Asp Pro Ala Tyr Ala Pro Gly Thr 
        275                 280                 285             


Gly Thr Pro Glu Ile Ala Gly Leu Thr Pro Ser Gln Ala Leu Glu Ile 
    290                 295                 300                 


Ile Arg Gly Cys Gln Gly Leu Asn Val Met Gly Cys Asp Leu Val Glu 
305                 310                 315                 320 


Val Ser Pro Pro Tyr Asp Leu Ser Gly Asn Thr Ala Leu Leu Ala Ala 
                325                 330                 335     


Asn Leu Leu Phe Glu Met Leu Cys Ala Leu Pro Lys Val Thr Thr Val 
            340                 345                 350         


<210>  5450
<211>  2272
<212>  DNA
<213>  Homosapiens

<400>  5450
agatcgcggc ggcctcgcgg gcggtttggt cggtgaggtc ttggccgcgc gcggcaatgc     60

tgaggctgct ggcgtccggg tgcgcccggg gcccggggcc cggcgtgggc gcgcgtcctg    120

ccgcagggct ctttcatccg gggcgccgcc agagccgcca ggcttccgac gcgccccgga    180

accagccccc cagccccgag ttcgtggccc ggccggtggg cgtctgctcc atgatgcgcc    240

tgccggtgca gacctccccc gaggggctgg acgctgccct ccccttccag tccctcatgg    300

ttgcagacct aggcgatgtg aatgtcaatc tttacaacct tcaggacagc tgccggcgaa    360

ttcaagaggc ctatgagaaa attgtagcag ctggctgtat tcctctgacc ttgggtggag    420

atcacacaat cacatatccc atattgcaag cgatggcaaa aaagcatggc ccagtggggc    480

tgctgcacgt ggatgcgcac acggacacga ccgacaaggc cctaggagag aagctctacc    540

acggggcgcc cttccgccgg tgtgtggatg agggtctcct ggactgtaag cgtgtggtgc    600

agattggcat ccggggctct tccacgacct tggatcccta cagatacaac cggagccagg    660

gcttccgggt agtcctggct gaagactgct ggatgaagtc gctggttcct ctgatggggg    720

aagtcaggca gcagatggga ggcaaaccca tttatatcag ctttgatatt gacgctctgg    780

atcctgccta tgcgccaggg acagggacac ctgaaattgc tggtctcact cctagtcagg    840

ctctggagat catcaggggt tgtcaaggcc tgaacgtgat gggctgtgat cttgtcgaag    900

tttcaccacc gtatgatctt tctgggaaca cagccctgct ggcggctaac ctgctgtttg    960

agatgctatg tgctctcccc aaagtgacaa ccgtctgagt cttgtgctct tcaagacaaa   1020

acagattgcg tcgctgacaa gttctcaaga agaacttatg agtaagcagt ctgagaacta   1080

aagagtttat gccaagaaaa ctttctgctg aaagtgtcat tgctggctgt gaagtcggga   1140

taatcagtag aattctcacc caaacagcaa catttctaag gaacttggat taattggggg   1200

aaaaaaaaag gagtacttgt actgctttga ttttttttcc tttgatgaaa gatggaggat   1260

aaaggggaag tgaggagaat ttctttcaag attatctaaa cattagaaac atgacattta   1320

aaaaaactat gaaataatac tgtataagca ttccatattt ctatatcttc cttttaaaca   1380

tttttttttt tgagatagag ttttgcttgt cacccaggct ggagtgcaat ggcatgatct   1440

cggttcattg caacctccgc ctcccgagtt caatcgattc tcctgcctca gcctcctgag   1500

tacctgggat tacaggtgcc tgccaccacg cctggctaat ttttgtattt ttagtagaga   1560

cagggtttca ccacattggc caggctggtc ttgaactcct gacctaaggt gatccgcccg   1620

cctcagcctc cttaaagtgc tgggattaca ggcatgagcc accgcaccca gccgcttttt   1680

aaaattttga tgatctgctt cctagagtat tgagtatctt cctttaaact acagctcctc   1740

ctcggacgct gcagtgagct gagatcgcac cactgcactc cagcctgggt gccagagcaa   1800

gactccatct caaaaaaaaa aaaaaaaaat acagcttctc ctatgaggtg cttagggctg   1860

catcttggtt ttaggaccac tgtgaacgta agtaaaaagt ataaagtaac acggagagcc   1920

taatgaagaa acttcttgct cagaggccta gaagggtaca caaaatgtct tctaaactag   1980

aaaacctaag gctggacacg gtggctcatg cctgtaatcc cagcactttg gggggcggag   2040

gtgggcagat cacttgaggt caggagttcg agaccagcct ggccaacatg gtgaaaaccc   2100

atctctactg aaaatacaga agttagctgg gcgtggtggc gcgtgcctat agtcccagct   2160

actcaggaag ctgaggcagg ggcattgctt gaacccggga ggtggaggtt gcagtgagct   2220

gaggtcatgc cactacactc cagcctgggt gacagagtga gactccgtct cc           2272


<210>  5451
<211>  313
<212>  PRT
<213>  Homosapiens

<400>  5451

Met Leu Arg Leu Leu Ala Ser Gly Cys Ala Arg Gly Pro Gly Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Pro Ala Ala Gly Leu Phe His Pro Gly Arg Arg Gln 
            20                  25                  30          


Ser Arg Gln Ala Ser Asp Ala Pro Arg Asn Gln Pro Pro Ser Pro Glu 
        35                  40                  45              


Phe Val Ala Arg Pro Val Gly Val Cys Ser Met Met Arg Leu Pro Val 
    50                  55                  60                  


Gln Thr Ser Pro Glu Gly Leu Asp Ala Ala Leu Pro Phe Gln Ser Leu 
65                  70                  75                  80  


Met Val Ala Asp Leu Gly Asp Val Asn Val Asn Leu Tyr Asn Leu Gln 
                85                  90                  95      


Asp Ser Cys Arg Arg Ile Gln Glu Ala Tyr Glu Lys Ile Val Ala Ala 
            100                 105                 110         


Gly Cys Ile Pro Leu Thr Leu Gly Gly Asp His Thr Ile Thr Tyr Pro 
        115                 120                 125             


Ile Leu Gln Ala Met Ala Lys Lys His Gly Pro Val Gly Leu Leu His 
    130                 135                 140                 


Val Asp Ala His Thr Asp Thr Thr Asp Lys Ala Leu Gly Glu Lys Leu 
145                 150                 155                 160 


Tyr His Gly Ala Pro Phe Arg Arg Cys Val Asp Glu Gly Leu Leu Asp 
                165                 170                 175     


Cys Lys Arg Val Val Gln Ile Gly Ile Arg Gly Ser Ser Thr Thr Leu 
            180                 185                 190         


Asp Pro Tyr Arg Tyr Asn Arg Ser Gln Gly Phe Arg Val Val Leu Ala 
        195                 200                 205             


Glu Asp Cys Trp Met Lys Ser Leu Val Pro Leu Met Gly Glu Val Arg 
    210                 215                 220                 


Gln Gln Met Gly Gly Lys Pro Ile Tyr Ile Ser Phe Asp Ile Asp Ala 
225                 230                 235                 240 


Leu Asp Pro Ala Tyr Ala Pro Gly Thr Gly Thr Pro Glu Ile Ala Gly 
                245                 250                 255     


Leu Thr Pro Ser Gln Ala Leu Glu Ile Ile Arg Gly Cys Gln Gly Leu 
            260                 265                 270         


Asn Val Met Gly Cys Asp Leu Val Glu Val Ser Pro Pro Tyr Asp Leu 
        275                 280                 285             


Ser Gly Asn Thr Ala Leu Leu Ala Ala Asn Leu Leu Phe Glu Met Leu 
    290                 295                 300                 


Cys Ala Leu Pro Lys Val Thr Thr Val 
305                 310             


<210>  5452
<211>  2196
<212>  DNA
<213>  Homosapiens

<400>  5452
cttgatccta gggcgcccct gacctttgag ccggctcggg ttccggctct ggcgcgtgca     60

cactcgcctc gccgttcggg accagccaga tcgcggcggc ctcgcgggcg gtttggtcgg    120

tgaggtcttg gccgcgcgcg gcaatgctga ggctgctggc gtccgggtgc gcccggggcc    180

cggggcccgg cgtgggcgcg cgtcctgccg cagggctctt tcatccgggg cgccgccaga    240

gccgccaggc ttccgacgcg ccccggaacc agccccccag ccccgagttc gtggcccggc    300

cggtgggcgt ctgctccatg atgcgcctgc cggtgcagac ctcccccgag gggctggacg    360

ctgccttcat cggggtgccc ctggatactg ggacctccaa ccggcctggg gcgagattcg    420

gacctcgccg catccgggaa gaatcagtga tgcttgggac agtcaatcct agcacggggg    480

ccctcccctt ccagtccctc atggttgcag acctaggcga tgtgaatgtc aatctttaca    540

accttcagga cagctgccgg cgaattcaag aggcctatga gaaaattgta gcagctggct    600

gtattcctct gaccttgggt ggagatcaca caatcacata tcccatattg caagcgatgg    660

caaaaaagca tggcccagtg gggctgctgc acgtggatgc gcacacggac acgaccgaca    720

aggccctagg agagaagctc taccacgggg cgcccttccg ccggtgtgtg gatgagggtc    780

tcctggactg taagcgtgtg gtgcagattg gcatccgggg ctcttccacg accttggatc    840

cctacagata caaccggagc cagggcttcc gggtagtcct ggctgaagac tgctggatga    900

agtcgctggt tcctctgatg ggggaagtca ggcagcagat gggaggcaaa cccatttata    960

tcagctttga tattgacgct ctggatcctg cctatgcgcc agggacaggg acacctgaaa   1020

ttgctggtct cactcctagt caggctctgg agatcatcag gggttgtcaa ggcctgaacg   1080

tgatgggctg tgatcttgtc gaagtttcac caccgtatga tctttctggg aacacagccc   1140

tgctggcggc taacctgctg tttgagatgc tatgtgctct ccccaaagtg acaaccgtct   1200

gagtcttgtg ctcttcaaga caaaacagat tgcgtcgctg acaagttctc aagaagaact   1260

tatgagtaag cagtctgaga actaaagagt ttatgccaag aaaactttct gctgaaagtg   1320

tcattgctgg ctgtgaagtc gggataatca gtagaattct cacccaaaca gcaacatttc   1380

taaggaactt ggattaattg ggggaaaaaa aaaggagtac ttgtactgct ttgatttttt   1440

ttcctttgat gaaagatgga ggataaaggg gaagtgagga gaatttcttt caagattatc   1500

taaacattag aaacatgaca tttaaaaaaa ctatgaaata atactgtata agcattccat   1560

atttctatat cttcctttta aacatttttt tttttgagat agagttttgc ttgtcaccca   1620

ggctggagtg caatggcatg atctcggttc attgcaacct ccgcctcccg agttcaatcg   1680

attctcctgc ctcagcctcc tgagtacctg ggattacagg tgcctgccac cacgcctggc   1740

taatttttgt atttttagta gagacagggt ttcaccacat tggccaggct ggtcttgaac   1800

tcctgaccta aggtgatccg cccgcctcag cctccttaaa gtgctgggat tacaggcatg   1860

agccaccgca cccagccgct ttttaaaatt ttgatgatct gcttcctaga gtattgagta   1920

tcttccttta aactacagct cctcctcgga cgctgcagtg agctgagatc gcaccactgc   1980

actccagcct gggtgccaga gcaagactcc atctcaaaaa aaaaaaaaaa aaatacagct   2040

tctcctatga ggtgcttagg gctgcatctt ggttttagga ccactgtgaa cgtaagtaaa   2100

aagtataaag taacacggag agcctaatga agaaacttct tgctcagagg cctagaaggg   2160

tacacaaaat gtcttctaaa ctagaaaacc taaggc                             2196


<210>  5453
<211>  352
<212>  PRT
<213>  Homosapiens

<400>  5453

Met Leu Arg Leu Leu Ala Ser Gly Cys Ala Arg Gly Pro Gly Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Pro Ala Ala Gly Leu Phe His Pro Gly Arg Arg Gln 
            20                  25                  30          


Ser Arg Gln Ala Ser Asp Ala Pro Arg Asn Gln Pro Pro Ser Pro Glu 
        35                  40                  45              


Phe Val Ala Arg Pro Val Gly Val Cys Ser Met Met Arg Leu Pro Val 
    50                  55                  60                  


Gln Thr Ser Pro Glu Gly Leu Asp Ala Ala Phe Ile Gly Val Pro Leu 
65                  70                  75                  80  


Asp Thr Gly Thr Ser Asn Arg Pro Gly Ala Arg Phe Gly Pro Arg Arg 
                85                  90                  95      


Ile Arg Glu Glu Ser Val Met Leu Gly Thr Val Asn Pro Ser Thr Gly 
            100                 105                 110         


Ala Leu Pro Phe Gln Ser Leu Met Val Ala Asp Leu Gly Asp Val Asn 
        115                 120                 125             


Val Asn Leu Tyr Asn Leu Gln Asp Ser Cys Arg Arg Ile Gln Glu Ala 
    130                 135                 140                 


Tyr Glu Lys Ile Val Ala Ala Gly Cys Ile Pro Leu Thr Leu Gly Gly 
145                 150                 155                 160 


Asp His Thr Ile Thr Tyr Pro Ile Leu Gln Ala Met Ala Lys Lys His 
                165                 170                 175     


Gly Pro Val Gly Leu Leu His Val Asp Ala His Thr Asp Thr Thr Asp 
            180                 185                 190         


Lys Ala Leu Gly Glu Lys Leu Tyr His Gly Ala Pro Phe Arg Arg Cys 
        195                 200                 205             


Val Asp Glu Gly Leu Leu Asp Cys Lys Arg Val Val Gln Ile Gly Ile 
    210                 215                 220                 


Arg Gly Ser Ser Thr Thr Leu Asp Pro Tyr Arg Tyr Asn Arg Ser Gln 
225                 230                 235                 240 


Gly Phe Arg Val Val Leu Ala Glu Asp Cys Trp Met Lys Ser Leu Val 
                245                 250                 255     


Pro Leu Met Gly Glu Val Arg Gln Gln Met Gly Gly Lys Pro Ile Tyr 
            260                 265                 270         


Ile Ser Phe Asp Ile Asp Ala Leu Asp Pro Ala Tyr Ala Pro Gly Thr 
        275                 280                 285             


Gly Thr Pro Glu Ile Ala Gly Leu Thr Pro Ser Gln Ala Leu Glu Ile 
    290                 295                 300                 


Ile Arg Gly Cys Gln Gly Leu Asn Val Met Gly Cys Asp Leu Val Glu 
305                 310                 315                 320 


Val Ser Pro Pro Tyr Asp Leu Ser Gly Asn Thr Ala Leu Leu Ala Ala 
                325                 330                 335     


Asn Leu Leu Phe Glu Met Leu Cys Ala Leu Pro Lys Val Thr Thr Val 
            340                 345                 350         


<210>  5454
<211>  1053
<212>  DNA
<213>  Homosapiens

<400>  5454
ccttccagtc cctcatggtt gcagacctag gcgatgtgaa tgtcaatctt tacaaccttc     60

aggacagctg ccggcgaatt caagaggcct atgagaaaat tgtagcagct ggctgtattc    120

ctctgacctt gggtggagat cacacaatca catatcccat attgcaagcg atggcaaaaa    180

agcatggccc agtggggctg ctgcacgtgg atgcgcacac ggacacgacc gacaaggccc    240

taggagagaa gctctaccac ggggcgccct tccgccggtg tgtggatgag ggtctcctgg    300

actgtaagcg tgtggtgcag attggcatcc ggggctcttc cacgaccttg gatccctaca    360

gatacaaccg gagccagggc ttccgggtag tcctggctga agactgctgg atgaagtcgc    420

tggttcctct gatgggggaa gtcaggcagc agatgggagg caaacccatt tatatcagct    480

ttgatattga cgctctggat cctgcctatg cgccagggac agggacacct gaaattgctg    540

gtctcactcc tagtcaggct ctggagatca tcaggggttg tcaaggcctg aacgtgatgg    600

gctgtgatct tgtcgaagtt tcaccaccgt atgatctttc tgggaacaca gccctgctgg    660

cggctaacct gctgtttgag atgctatgtg ctctccccaa agtgacaacc gtctgagtct    720

tgtgctcttc aagacaaaac agattgcgtc gctgacaagt tctcaagaag aacttatgag    780

taagcagtct gagaactaaa gagtttatgc caagaaaact ttctgctgaa agtgtcattg    840

ctggctgtga agtcgggata atcagtagaa ttctcaccca aacagcaaca tttctaagga    900

acttggatta attgggggaa aaaaaaagga gtacttgtac tgctttgatt ttttttcctt    960

tgatgaaaga tggaggataa aggggaagtg aggagaattt ctttcaagat tatctaaaca   1020

ttagaaacat gacatttaaa aaaactatga aat                                1053


<210>  5455
<211>  233
<212>  PRT
<213>  Homosapiens

<400>  5455

Met Val Ala Asp Leu Gly Asp Val Asn Val Asn Leu Tyr Asn Leu Gln 
1               5                   10                  15      


Asp Ser Cys Arg Arg Ile Gln Glu Ala Tyr Glu Lys Ile Val Ala Ala 
            20                  25                  30          


Gly Cys Ile Pro Leu Thr Leu Gly Gly Asp His Thr Ile Thr Tyr Pro 
        35                  40                  45              


Ile Leu Gln Ala Met Ala Lys Lys His Gly Pro Val Gly Leu Leu His 
    50                  55                  60                  


Val Asp Ala His Thr Asp Thr Thr Asp Lys Ala Leu Gly Glu Lys Leu 
65                  70                  75                  80  


Tyr His Gly Ala Pro Phe Arg Arg Cys Val Asp Glu Gly Leu Leu Asp 
                85                  90                  95      


Cys Lys Arg Val Val Gln Ile Gly Ile Arg Gly Ser Ser Thr Thr Leu 
            100                 105                 110         


Asp Pro Tyr Arg Tyr Asn Arg Ser Gln Gly Phe Arg Val Val Leu Ala 
        115                 120                 125             


Glu Asp Cys Trp Met Lys Ser Leu Val Pro Leu Met Gly Glu Val Arg 
    130                 135                 140                 


Gln Gln Met Gly Gly Lys Pro Ile Tyr Ile Ser Phe Asp Ile Asp Ala 
145                 150                 155                 160 


Leu Asp Pro Ala Tyr Ala Pro Gly Thr Gly Thr Pro Glu Ile Ala Gly 
                165                 170                 175     


Leu Thr Pro Ser Gln Ala Leu Glu Ile Ile Arg Gly Cys Gln Gly Leu 
            180                 185                 190         


Asn Val Met Gly Cys Asp Leu Val Glu Val Ser Pro Pro Tyr Asp Leu 
        195                 200                 205             


Ser Gly Asn Thr Ala Leu Leu Ala Ala Asn Leu Leu Phe Glu Met Leu 
    210                 215                 220                 


Cys Ala Leu Pro Lys Val Thr Thr Val 
225                 230             


<210>  5456
<211>  1300
<212>  DNA
<213>  Homosapiens

<400>  5456
cttgatccta gggcgcccct gacctttgag ccggctcggg ttccggctct ggcgcgtgca     60

cactcgcctc gccgttcggg accagccaga tcgcggcggc ctcgcgggcg gtttggtcgg    120

tgaggtcttg gccgcgcgcg gcaatgctga ggctgctggc gtccgggtgc gcccggggcc    180

cggggcccgg cgtgggcgcg cgtcctgccg cagggctctt tcatccgggg cgccgccaga    240

gccgccaggc ttccgacgcg ccccggaacc agccccccag ccccgagttc gtggcccggc    300

cggtgggcgt ctgctccatg atgcgcctgc cggtgcagac ctcccccgag gggctggacg    360

ctgccttcat cggggtgccc ctggatactg ggacctccaa ccggcctggg gcgagattcg    420

gacctcgccg catccgggaa gaatcagtga tgcttgggac agtcaatcct agcacggggg    480

ccctcccctt ccagtccctc atggttgcag acctaggcga tgtgaatgtc aatctttaca    540

accttcagga cagctgccgg cgaattcaag aggcctatga gaaaattgta gcagctggct    600

gtattcctct gaccttgggt ggagatcaca caatcacata tcccatattg caagcgatgg    660

caaaaaagca tggcccagtg gggctgctgc acgtggatgc gcacacggac acgaccgaca    720

aggccctagg agagaagctc taccacgggg cgcccttccg ccggtgtgtg gatgagggtc    780

tcctggactg taagcgtgtg gtgcagattg gcatccgggg ctcttccacg accttggatc    840

cctacagata caaccggagc cagggcttcc gggtagtcct ggctgaagac tgctggatga    900

agtcgctggt tcctctgatg ggggaagtca ggcagcagat gggaggcaaa cccatttata    960

tcagctttga tattgacgct ctggatcctg cctatgcgcc agggacaggg acacctgaaa   1020

ttgctggtct cactcctagt caggctctgg agatcatcag gggttgtcaa ggcctgaacg   1080

tgatgggctg tgatcttgtc gaagtttcac caccgtatga tctttctggg aacacagccc   1140

tgctggcggc taacctgctg tttgagatgc tatgtgctct ccccaaagtg acaaccgtct   1200

gagtcttgtg ctcttcaaga caaaacagat tgcgtcgctg acaagttctc aagaagaact   1260

tatgagtaag cagtctgaga actaaagagt ttatgccaag                         1300


<210>  5457
<211>  352
<212>  PRT
<213>  Homosapiens

<400>  5457

Met Leu Arg Leu Leu Ala Ser Gly Cys Ala Arg Gly Pro Gly Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Pro Ala Ala Gly Leu Phe His Pro Gly Arg Arg Gln 
            20                  25                  30          


Ser Arg Gln Ala Ser Asp Ala Pro Arg Asn Gln Pro Pro Ser Pro Glu 
        35                  40                  45              


Phe Val Ala Arg Pro Val Gly Val Cys Ser Met Met Arg Leu Pro Val 
    50                  55                  60                  


Gln Thr Ser Pro Glu Gly Leu Asp Ala Ala Phe Ile Gly Val Pro Leu 
65                  70                  75                  80  


Asp Thr Gly Thr Ser Asn Arg Pro Gly Ala Arg Phe Gly Pro Arg Arg 
                85                  90                  95      


Ile Arg Glu Glu Ser Val Met Leu Gly Thr Val Asn Pro Ser Thr Gly 
            100                 105                 110         


Ala Leu Pro Phe Gln Ser Leu Met Val Ala Asp Leu Gly Asp Val Asn 
        115                 120                 125             


Val Asn Leu Tyr Asn Leu Gln Asp Ser Cys Arg Arg Ile Gln Glu Ala 
    130                 135                 140                 


Tyr Glu Lys Ile Val Ala Ala Gly Cys Ile Pro Leu Thr Leu Gly Gly 
145                 150                 155                 160 


Asp His Thr Ile Thr Tyr Pro Ile Leu Gln Ala Met Ala Lys Lys His 
                165                 170                 175     


Gly Pro Val Gly Leu Leu His Val Asp Ala His Thr Asp Thr Thr Asp 
            180                 185                 190         


Lys Ala Leu Gly Glu Lys Leu Tyr His Gly Ala Pro Phe Arg Arg Cys 
        195                 200                 205             


Val Asp Glu Gly Leu Leu Asp Cys Lys Arg Val Val Gln Ile Gly Ile 
    210                 215                 220                 


Arg Gly Ser Ser Thr Thr Leu Asp Pro Tyr Arg Tyr Asn Arg Ser Gln 
225                 230                 235                 240 


Gly Phe Arg Val Val Leu Ala Glu Asp Cys Trp Met Lys Ser Leu Val 
                245                 250                 255     


Pro Leu Met Gly Glu Val Arg Gln Gln Met Gly Gly Lys Pro Ile Tyr 
            260                 265                 270         


Ile Ser Phe Asp Ile Asp Ala Leu Asp Pro Ala Tyr Ala Pro Gly Thr 
        275                 280                 285             


Gly Thr Pro Glu Ile Ala Gly Leu Thr Pro Ser Gln Ala Leu Glu Ile 
    290                 295                 300                 


Ile Arg Gly Cys Gln Gly Leu Asn Val Met Gly Cys Asp Leu Val Glu 
305                 310                 315                 320 


Val Ser Pro Pro Tyr Asp Leu Ser Gly Asn Thr Ala Leu Leu Ala Ala 
                325                 330                 335     


Asn Leu Leu Phe Glu Met Leu Cys Ala Leu Pro Lys Val Thr Thr Val 
            340                 345                 350         


<210>  5458
<211>  2860
<212>  DNA
<213>  Homosapiens

<400>  5458
atgcctggcg tccgcgcatt tggctcctgg ttgctaggcg acgccaaccc gattctggtt     60

gctggagttt atcctcccga ggttgctgtg cgagtttcgg actcagctca agcgcttgga    120

tccctacagc acctgcgagg gcttctcctg gctgccgctt tcgttctggc gaatgttcgg    180

ggtggcagcc ccccttcgag gcttgcacga gggcgtcccg gcatccgcga tcaagcgggc    240

cctgctgctt ttggggctga ccctgcggct ggggtgctgc ggcgtcgctc tggctatgcc    300

cggtccactc acggactccc tgctttggcc tgctcagctc aggagaaccg ggcccgactc    360

catttcgggc agtggtggac agggaaacta gtgcctgcct gtagtggtcc caggcataga    420

gcttcctgca gctaccctgt ggcttagttc acgttttgtt gctttgacca ccgatgagaa    480

atgtgcagta gggaccctgt aggagtctgc ttacccgaaa tggtttctgt cttgaatagt    540

tgttgagtga aagctcttgc tgctgctcac tctttgggtc tgtgccgcct tcatgagctg    600

tgacactcac cgtgaagttt tgcagcttcg ctcctaaagc cagcgagacc acgaacccac    660

tgggagggac agcaactctg gacgcgccac ttttacgaac tgtagcactc accgcaaagg    720

tctgcagctt cactcctgag gccagcgaga ccacgaaccc accgtgaagg aacgaacaac    780

tccagacgcg ccgcctttaa gagctgtaac actgcaaagg tctgcagctt cactcctgaa    840

gtcagcgtag accacgaacc tagcagaagg aagaaacttc ggacacatct gaacatctga    900

aggaacaaac tccggacaca ctatctttaa gaactgtaac accgcgaggg tctgtggctt    960

cattcttgaa gtcagcgaga caaagaaccc accaattcga tacactggga ccacaggtgt   1020

gcaccaccag tcttggctaa cttttgtatt ctttgtagag acaggatttc cccatgttgg   1080

ccaggctggt ctcaagctcc tggactcaag ccatgtgcct gccttggtct cacaaagtgc   1140

taggattacg ggcatgaggc accgcaccca gtgagaccct atttctacaa aaaatacaaa   1200

aattagctgg gcatagttgt gtgcacctgt agtcctagct acttgggagg ctgaggcaga   1260

aggattgctc aagcccaggg ggtggaggct gcagtgagct atgactgtac cacagcacca   1320

cagccttcat gacagagcga gacttctatc tcccttaaaa aaaaaaaaag ttcagggtct   1380

tttgagggtg ggcttctact gaacattgga catgtggagc tgagggctgg ggtggagcac   1440

tgcaggcaga cagaaaagca tgaacaaagg aaaggaggca agaaagtggg ggctgaggca   1500

gctgaccatg ggctggagga acaagcccgt ggagctgcag aaggggaaac acaggaagaa   1560

ttggctccag gaagcattac cgggcaggca tatgtatggt gatactagtg agagtgagat   1620

cagctggaaa gctggggtgg gaaggcctgg accagagtaa cagcagagga aatgagcaga   1680

aggcttgggg gcaggaaacc atcaggactt cttaaatttg ggggcgtaga gcaggatcag   1740

agacagggag gtggaaagtc gctggctgaa cttgcagccc accccaggtg ctgtcaagca   1800

tccaggtcag ggttagaaat tggtcgcctg gagctcaggg ctgggatttg ggcttgtggt   1860

tgacctgcct atgggtgaaa gtcatcacct ccgtattaaa agggattgcc agccgagaag   1920

gagccacgaa ggtggaagga gaccagggga gtcccagtca agaggccgcc tgaggaacgt   1980

ttcaaggaga gagggtgctc agcagtagtg gatgttgggg acacctcatt ggaacgcctg   2040

gcacatagcg gacactcaat atttgtgagc tgaatgaaag aaaaacccgg agtaagaaca   2100

tgatacattc aggacaagca acatgaaaga aatagcagtt gaatttggga gtcaagagaa   2160

taactgagac cctttaagtg gcataaggga gaaaaaaagg aaaaaataac tgagagattg   2220

ttgcatttgt tccagaaaat ggctgggacc tgccccaagg ccaacactaa gcactgataa   2280

ttgaccatta ggaaactctg tcccgacctg cagagtggag gctccactcc agagtggagg   2340

ctggagtggt gtggggttta atgtgcaacc tttttttttt tttttgacag agtcttgctg   2400

tgttgcccag gctggagtgc agtggcgcga tcttggctca ctgcaaactc caccctcccg   2460

ggttcacgtc attctcccgc ctcaggctcc cgagtagctg gtactacagg tgcccaccac   2520

cacgcctggc taattttttg tatttttagt agagatgggg tttcaccatg ttagccaaga   2580

tggtctcatc tcctgacctc atgatccgcc cacctcggcc tcccaaagtg ctgggattac   2640

aggtgtgagc caccgcgcct ggcctaatgt gcaacctttg tgtagaggtt gcaacgtaaa   2700

tgcaaatgtg agccttttcc attcaatctc aacatttaga gatcagaaaa aataatatat   2760

ataatactgc taaatggctc acataattcc attacaaatc acttctttct ttccacgtgt   2820

gtttttcttt ccccttagaa ataaagagga tgtaacaggt                         2860


<210>  5459
<211>  148
<212>  PRT
<213>  Homosapiens

<400>  5459

Met Pro Gly Val Arg Ala Phe Gly Ser Trp Leu Leu Gly Asp Ala Asn 
1               5                   10                  15      


Pro Ile Leu Val Ala Gly Val Tyr Pro Pro Glu Val Ala Val Arg Val 
            20                  25                  30          


Ser Asp Ser Ala Gln Ala Leu Gly Ser Leu Gln His Leu Arg Gly Leu 
        35                  40                  45              


Leu Leu Ala Ala Ala Phe Val Leu Ala Asn Val Arg Gly Gly Ser Pro 
    50                  55                  60                  


Pro Ser Arg Leu Ala Arg Gly Arg Pro Gly Ile Arg Asp Gln Ala Gly 
65                  70                  75                  80  


Pro Ala Ala Phe Gly Ala Asp Pro Ala Ala Gly Val Leu Arg Arg Arg 
                85                  90                  95      


Ser Gly Tyr Ala Arg Ser Thr His Gly Leu Pro Ala Leu Ala Cys Ser 
            100                 105                 110         


Ala Gln Glu Asn Arg Ala Arg Leu His Phe Gly Gln Trp Trp Thr Gly 
        115                 120                 125             


Lys Leu Val Pro Ala Cys Ser Gly Pro Arg His Arg Ala Ser Cys Ser 
    130                 135                 140                 


Tyr Pro Val Ala 
145             


<210>  5460
<211>  797
<212>  DNA
<213>  Homosapiens

<400>  5460
atgaggctag ttcagttgtg caagagcatt tcctcaaagc cgagccgtcg cgtacctagg     60

atacctggaa gccgaagcca cacctcccgc atggcccctc cggccagccg ggcccctcag    120

atgagagctg cacccaggcc agcaccagtc gctcagccac cagcagcggc accgccatct    180

acagttggct cttctgctgc tgcgccccgg cagccaggtc tgatggccca gatggcaacc    240

actgcagctg gcgtggctgt gggctctgct gtggggcaca tactgggtca tgccattact    300

gggggcttca gtggaggaag taatgctgag cctgcgaggc ctgacatcac ttaccaggag    360

cctcagggaa cccagccggc acagcagcag cagccttgct tctgtgagat caaacagttt    420

ctggagtgtg ccgagaacca gggtgacatc aagctctgtg agggtttcaa tgaggtgctg    480

aaacagtgcc gacttgcaaa cggattggcc taatcaagaa gttcaacctg gagagatgga    540

aaatcagctc tcatactaat taatttagta taaaaataga attggtagtg agggtataaa    600

gtgtaagcat cagttaaact tctcctgtca ttcctagctt ccttgcttca gaattgaaat    660

ggaagggagg gtgttcctac tctgtagaat ctgggactgg gcaaatgttt gtgtggcctc    720

cttaaactag ctgttatgat tttattcttt gtgagttaat tagaataaag tcattttctt    780

ccaaaaaaga aaaaaaa                                                   797


<210>  5461
<211>  170
<212>  PRT
<213>  Homosapiens

<400>  5461

Met Arg Leu Val Gln Leu Cys Lys Ser Ile Ser Ser Lys Pro Ser Arg 
1               5                   10                  15      


Arg Val Pro Arg Ile Pro Gly Ser Arg Ser His Thr Ser Arg Met Ala 
            20                  25                  30          


Pro Pro Ala Ser Arg Ala Pro Gln Met Arg Ala Ala Pro Arg Pro Ala 
        35                  40                  45              


Pro Val Ala Gln Pro Pro Ala Ala Ala Pro Pro Ser Thr Val Gly Ser 
    50                  55                  60                  


Ser Ala Ala Ala Pro Arg Gln Pro Gly Leu Met Ala Gln Met Ala Thr 
65                  70                  75                  80  


Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Ile Leu Gly 
                85                  90                  95      


His Ala Ile Thr Gly Gly Phe Ser Gly Gly Ser Asn Ala Glu Pro Ala 
            100                 105                 110         


Arg Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Pro Ala Gln 
        115                 120                 125             


Gln Gln Gln Pro Cys Phe Cys Glu Ile Lys Gln Phe Leu Glu Cys Ala 
    130                 135                 140                 


Glu Asn Gln Gly Asp Ile Lys Leu Cys Glu Gly Phe Asn Glu Val Leu 
145                 150                 155                 160 


Lys Gln Cys Arg Leu Ala Asn Gly Leu Ala 
                165                 170 


<210>  5462
<211>  1500
<212>  DNA
<213>  Homosapiens

<400>  5462
ggagggagcg agcgagcgaa cgagcagccg gcgccgtcct cccgcagcac cagccaggcc     60

acgccgccgc ctcttcccct gcgccccgcg cccaggccgg gccgagccga gccgagccgg    120

gtcgggcccg ggccatgctg ctcaccgtgt actgtgtgcg gagggacctc tccgaggtga    180

ccttttccct ccaggtcgac gccgacttcg agctgcacaa cttccgcgcg ctgtgcgagc    240

tcgagtctgg catccccgca gccgagagcc agatcgtcta tgcggaaaga cctctcacag    300

acaaccacag atcattggct tcttatggct tgaaagatgg ggacgttgtg attttacgac    360

agaaggagaa tgcagaccct cgacctccag tgcagttccc aaacttaccc cgaatagatt    420

tcagtagtat agctgtgcct ggcacatcaa gtccccggca gcgccagcca ccaggaacac    480

agcagtccca ctcatctcct ggagaaataa cttcatctcc tcagggcttg gacaatccag    540

ccttgctccg agatatgttg ctggccaacc cgcatgagct gtccttgctg aaggaacgca    600

atccacccct ggcagaagct ctgctcagtg gagaccttga gaaattttct agagtcctgg    660

tggagcagca gcaggaccga gcccggagag agcaagaaag gattcgtctg ttttctgctg    720

atccctttga ccttgaagct caggcaaaga tagaagaaga tataaggtaa agacctgttc    780

atctaaagaa caaaacttag agactccaga tttcccagac tgcaggttat ctgacattgg    840

ttgggcatct gcttggaggt agcttctctg ttttgcagtt gagatagtaa cctcagtctt    900

ttaggttagt ctctcctctt tcattttcta tgcatttcga tttgacatga caaagatata    960

ggtgcttagt ttaatgactt tctttctaaa attttaagga ggactccctg actagcagac   1020

agagcatcat aacacagctt tagataaatg acccccggac tgagcagaag ccaccatctg   1080

gtgagaccac aaggctggtt gcatattaca tgggctgatt tgactctctt tctttagaca   1140

tattgtataa gtcctgatta aatccagggc ttaaacatga ttggattaga gagggctctg   1200

cgccgatgga acgttggtag tcctaagtct gttttcctgc tgcatttctt gtactggcct   1260

cagtggataa actgaatgct ggacatgttt ccagctctca gtttctgtaa tgcggtggtt   1320

ctcacctggg gctatagtaa aatcacatga gaaactttta aaaatgcaga tgcttggact   1380

cttctcccaa atctgatgaa tcagaattgt cgggcatgga gctcaagcaa ggacagtgac   1440

gctgttccgg cctcagtcac actgatagtc acaagcaaga ttctgttcag tcattctctg   1500


<210>  5463
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  5463

Met Leu Leu Thr Val Tyr Cys Val Arg Arg Asp Leu Ser Glu Val Thr 
1               5                   10                  15      


Phe Ser Leu Gln Val Asp Ala Asp Phe Glu Leu His Asn Phe Arg Ala 
            20                  25                  30          


Leu Cys Glu Leu Glu Ser Gly Ile Pro Ala Ala Glu Ser Gln Ile Val 
        35                  40                  45              


Tyr Ala Glu Arg Pro Leu Thr Asp Asn His Arg Ser Leu Ala Ser Tyr 
    50                  55                  60                  


Gly Leu Lys Asp Gly Asp Val Val Ile Leu Arg Gln Lys Glu Asn Ala 
65                  70                  75                  80  


Asp Pro Arg Pro Pro Val Gln Phe Pro Asn Leu Pro Arg Ile Asp Phe 
                85                  90                  95      


Ser Ser Ile Ala Val Pro Gly Thr Ser Ser Pro Arg Gln Arg Gln Pro 
            100                 105                 110         


Pro Gly Thr Gln Gln Ser His Ser Ser Pro Gly Glu Ile Thr Ser Ser 
        115                 120                 125             


Pro Gln Gly Leu Asp Asn Pro Ala Leu Leu Arg Asp Met Leu Leu Ala 
    130                 135                 140                 


Asn Pro His Glu Leu Ser Leu Leu Lys Glu Arg Asn Pro Pro Leu Ala 
145                 150                 155                 160 


Glu Ala Leu Leu Ser Gly Asp Leu Glu Lys Phe Ser Arg Val Leu Val 
                165                 170                 175     


Glu Gln Gln Gln Asp Arg Ala Arg Arg Glu Gln Glu Arg Ile Arg Leu 
            180                 185                 190         


Phe Ser Ala Asp Pro Phe Asp Leu Glu Ala Gln Ala Lys Ile Glu Glu 
        195                 200                 205             


Asp Ile Arg 
    210     


<210>  5464
<211>  303
<212>  DNA
<213>  Homosapiens

<400>  5464
gggtgggatc tgaagctgtg gtgatggtgg tttgaaacta atctcataag gagtggaaac     60

cattgaggac ttttaagcag atgaagaagt aagtgatttg aaaatggtgc tattggccca    120

gtgcagtggc tcaaacctgt aatcccagca cgttgggagg ctgaggcggg tggatcacct    180

gaggtcagga gttcaagacc agcctggcca acatgctgaa gccccatctc tactaaaaat    240

acaaaaaata gccgggcatg gtggcacttg catgtaatcc cagctactcg ggaggctgag    300

gca                                                                  303


<210>  5465
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5465

Phe Glu Asn Gly Ala Ile Gly Pro Val Gln Trp Leu Lys Pro Val Ile 
1               5                   10                  15      


Pro Ala Arg Trp Glu Ala Glu Ala Gly Gly Ser Pro Glu Val Arg Ser 
            20                  25                  30          


Ser Arg Pro Ala Trp Pro Thr Cys 
        35                  40  


<210>  5466
<211>  757
<212>  DNA
<213>  Homosapiens

<400>  5466
agtgttccat cgacctgaag aaaaatgtac tcgtgatcgg caccacaggc tcccagacca     60

cctttcttcc tgagggagag ctaccagagt gtgcccggtt ggcatatggg gctggaagag    120

aggatgtacg gccagaggag attgcagacc aagaattagc agaagccctt caaaaatcag    180

cagaggatgc agattgctgt gtgtattgtg agagaatgga agcaaccaac aaatattttg    240

gatgtccaaa ctacagaaac atccctcaac ttggaatcta ccagttcctg attttaaaga    300

tggcaaaaga acggaaacta taaccctgca tgctgtgtgg tttgcattgt taacccaagt    360

ttgcttgtct gtttcctaat tcacacagag cgtcagaagc catgatgcat gtagtgtgtg    420

tgtactgcag ctggagtggg ccccagacca ggtatttata gacaccatgt taagccttcc    480

atccagttgt catctgtgat ctgacagtct gtatccgcag cagtttggga agttagcatt    540

tgtcattcac catttcacct tgttcaatct ggttacaact agcctatatg catttgtatt    600

ttggcatgca tacatggata tgtaacataa actcctgttt aaaaatggat tcgttattag    660

aaccatccaa cagggagaaa atcccagtta aaacagtgtc tattatatct accccatctt    720

ggctactata aatatcacat caagaatatt ggcctca                             757


<210>  5467
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  5467

Met Gln Ile Ala Val Cys Ile Val Arg Glu Trp Lys Gln Pro Thr Asn 
1               5                   10                  15      


Ile Leu Asp Val Gln Thr Thr Glu Thr Ser Leu Asn Leu Glu Ser Thr 
            20                  25                  30          


Ser Ser 
        


<210>  5468
<211>  2722
<212>  DNA
<213>  Homosapiens

<400>  5468
aatctgttga aattaacaga ttgctgtgtg tattgtgaga gaatggaagc aaccaacaaa     60

tattttggat gtccaaacta cagaaacatc cctcaacttg gaatctacca gttcctgatt    120

ttaaagatgg caaaagaacg gaaactataa ccctgcatgc tgtgtggttt gcattgttaa    180

cccaagtttg cttgtctgtt tcctaattca cacagagcgt cagaagccat gatgcatgta    240

gtgtgtgtgt actgcagctg gagtgggccc cagaccagag aaaagtggta aagaatctac    300

ctcactggga atgtcatcat taccaacttc agatgggttt aaccatcccg cccgttcttc    360

aggacagagt cctgatgttg gtaatcctat gagtcttgct cgctctgtct ctgcttcagt    420

ctgccctatc aagcccagtg actcagatcg cattgaacct aaagctgtga aggctttgaa    480

ggcttcagct gaattccagc taaactctga aaagaaagaa catctttctt tacaagatct    540

ttctgatcat gcttcctcag cagaccatgc tccaacagac cagagtccag ctatgcctat    600

gcagaattca tccgaagaaa taactgttgc aggtaatctg gagaaatctg ctgaaagaag    660

cacccagggc ctcaaatttc atctccatac aagacaggaa gctagtttat ctgtcacatc    720

tactaggatg catgaaccac agatgtttct aggtgaaaag gattggcatc cagaaaatca    780

gaacctgagt caagtgagtg accctcagca gcacgaagaa ccagggaatg aacagtatga    840

ggttgcacaa caaaaagctt cacatgacca agaatatctt tgtaacatag gggaccttga    900

gcttcctgaa gaaaggcaac agaatcaaca caaaattgtt gatttggaag ctacgatgaa    960

aggaaatggg ctcccacaga atgtggatcc tccaagtgcg aagaaaagta ttccatcttc   1020

agaatgcagt ggctgctcaa attcagaaac atttatggaa atcgatacag ctcaacagtc   1080

cctagttact ttgcttaatt caacaggcag gcagaatgcc aatgtcaaga acattggtgc   1140

attggatctc actttagata atcccttgat ggaagtagaa acatcaaaat gtaacccttc   1200

atctgaaatt ttgaatgatt ccatttccac tcaggattta cagcccccag aaactaatgt   1260

tgaaatacct ggaacaaata aagaatatgg ccattactcc tctccaagtc tctgtggcag   1320

ttgtcagcct tctgtggagt cagcagaaga atcttgcccg tctataacgg cagccttgaa   1380

agaacttcat gaacttttgg ttgttagcag taaaccagct tcagaaaata catctgaaga   1440

agtaatctgt caatcagaaa ccatagctga gggccaaacc agtattaaag acctttctga   1500

aagatggacc caaaatgagc atcttaccca gaatgaacag tgtccacaag tctcctttca   1560

tcaggccata tctgtatcag tggagacaga aaaattaaca ggtacttcat ctgacactgg   1620

aagagaagct gtagaaaatg taaacttcag gagtctaggt gatggcctgt caaccgataa   1680

ggaaggtgtc cccaaatcta gggaatccat aaataagaac cgttctgtca ctgtaacctc   1740

agctaaaaca tccaatcagt tacactgcac cttaggtgta gaaatttcac ccaaactttt   1800

agcaggtgag gaggatgcac tcaatcagac ttctgagcaa actaagtctt tgtcatccaa   1860

tttcatattg gttaaagact taggtcaggg catacagaat tcagtaacag acaggcctga   1920

aaccagagaa aatgtctgtc ctgatgcttc gaggccatta cttgaatatg aaccacctac   1980

cagccatcca tcatcaagtc ctgccattct tccaccattg atttttcctg ccacagatat   2040

tgaccgcatt ctccgtgctg gctttacttt gcaggaagct cttggagctt tgcatcgagt   2100

tggtgggaat gcagaccttg cacttcttgt tttgctcgca aaaaacatcg tagttcctac   2160

atgactgtgg gaaagtgggc tagaccgttc tccattccct ttaaacaaaa gaaagctctc   2220

tctatataca cgcacacata cacactcacc acatatacag tatatataga aacctgcaag   2280

cagaatgttg agccagattt tttttaaaga tttttttcgg ccaaagtaat ttatgatctt   2340

ttgtctgatg aatttgtcta tcctacttgt taaaatttag gcctttttaa atgtattggc   2400

agtatgtgca tacagaagct ttttattctc attaagatgt atcctggaat aaaatggatg   2460

gttttgtgtg tagcatactg ttttagaatg agagtaaatg ctttgaaaag cagaagccat   2520

gagaaatccc actacccatc cagctaaaaa cagatgaact ctccacactg tgactgtgtg   2580

tctgtgctga tggcaaggta tggtttgctg gctcagttgt caatttagaa acttttgacc   2640

acataatttg gtgtttggaa ttctacccag tgctctgtgt atcatgattc attaattata   2700

acaggaaatt ggagaataat tg                                            2722


<210>  5469
<211>  617
<212>  PRT
<213>  Homosapiens

<400>  5469

Met Ser Ser Leu Pro Thr Ser Asp Gly Phe Asn His Pro Ala Arg Ser 
1               5                   10                  15      


Ser Gly Gln Ser Pro Asp Val Gly Asn Pro Met Ser Leu Ala Arg Ser 
            20                  25                  30          


Val Ser Ala Ser Val Cys Pro Ile Lys Pro Ser Asp Ser Asp Arg Ile 
        35                  40                  45              


Glu Pro Lys Ala Val Lys Ala Leu Lys Ala Ser Ala Glu Phe Gln Leu 
    50                  55                  60                  


Asn Ser Glu Lys Lys Glu His Leu Ser Leu Gln Asp Leu Ser Asp His 
65                  70                  75                  80  


Ala Ser Ser Ala Asp His Ala Pro Thr Asp Gln Ser Pro Ala Met Pro 
                85                  90                  95      


Met Gln Asn Ser Ser Glu Glu Ile Thr Val Ala Gly Asn Leu Glu Lys 
            100                 105                 110         


Ser Ala Glu Arg Ser Thr Gln Gly Leu Lys Phe His Leu His Thr Arg 
        115                 120                 125             


Gln Glu Ala Ser Leu Ser Val Thr Ser Thr Arg Met His Glu Pro Gln 
    130                 135                 140                 


Met Phe Leu Gly Glu Lys Asp Trp His Pro Glu Asn Gln Asn Leu Ser 
145                 150                 155                 160 


Gln Val Ser Asp Pro Gln Gln His Glu Glu Pro Gly Asn Glu Gln Tyr 
                165                 170                 175     


Glu Val Ala Gln Gln Lys Ala Ser His Asp Gln Glu Tyr Leu Cys Asn 
            180                 185                 190         


Ile Gly Asp Leu Glu Leu Pro Glu Glu Arg Gln Gln Asn Gln His Lys 
        195                 200                 205             


Ile Val Asp Leu Glu Ala Thr Met Lys Gly Asn Gly Leu Pro Gln Asn 
    210                 215                 220                 


Val Asp Pro Pro Ser Ala Lys Lys Ser Ile Pro Ser Ser Glu Cys Ser 
225                 230                 235                 240 


Gly Cys Ser Asn Ser Glu Thr Phe Met Glu Ile Asp Thr Ala Gln Gln 
                245                 250                 255     


Ser Leu Val Thr Leu Leu Asn Ser Thr Gly Arg Gln Asn Ala Asn Val 
            260                 265                 270         


Lys Asn Ile Gly Ala Leu Asp Leu Thr Leu Asp Asn Pro Leu Met Glu 
        275                 280                 285             


Val Glu Thr Ser Lys Cys Asn Pro Ser Ser Glu Ile Leu Asn Asp Ser 
    290                 295                 300                 


Ile Ser Thr Gln Asp Leu Gln Pro Pro Glu Thr Asn Val Glu Ile Pro 
305                 310                 315                 320 


Gly Thr Asn Lys Glu Tyr Gly His Tyr Ser Ser Pro Ser Leu Cys Gly 
                325                 330                 335     


Ser Cys Gln Pro Ser Val Glu Ser Ala Glu Glu Ser Cys Pro Ser Ile 
            340                 345                 350         


Thr Ala Ala Leu Lys Glu Leu His Glu Leu Leu Val Val Ser Ser Lys 
        355                 360                 365             


Pro Ala Ser Glu Asn Thr Ser Glu Glu Val Ile Cys Gln Ser Glu Thr 
    370                 375                 380                 


Ile Ala Glu Gly Gln Thr Ser Ile Lys Asp Leu Ser Glu Arg Trp Thr 
385                 390                 395                 400 


Gln Asn Glu His Leu Thr Gln Asn Glu Gln Cys Pro Gln Val Ser Phe 
                405                 410                 415     


His Gln Ala Ile Ser Val Ser Val Glu Thr Glu Lys Leu Thr Gly Thr 
            420                 425                 430         


Ser Ser Asp Thr Gly Arg Glu Ala Val Glu Asn Val Asn Phe Arg Ser 
        435                 440                 445             


Leu Gly Asp Gly Leu Ser Thr Asp Lys Glu Gly Val Pro Lys Ser Arg 
    450                 455                 460                 


Glu Ser Ile Asn Lys Asn Arg Ser Val Thr Val Thr Ser Ala Lys Thr 
465                 470                 475                 480 


Ser Asn Gln Leu His Cys Thr Leu Gly Val Glu Ile Ser Pro Lys Leu 
                485                 490                 495     


Leu Ala Gly Glu Glu Asp Ala Leu Asn Gln Thr Ser Glu Gln Thr Lys 
            500                 505                 510         


Ser Leu Ser Ser Asn Phe Ile Leu Val Lys Asp Leu Gly Gln Gly Ile 
        515                 520                 525             


Gln Asn Ser Val Thr Asp Arg Pro Glu Thr Arg Glu Asn Val Cys Pro 
    530                 535                 540                 


Asp Ala Ser Arg Pro Leu Leu Glu Tyr Glu Pro Pro Thr Ser His Pro 
545                 550                 555                 560 


Ser Ser Ser Pro Ala Ile Leu Pro Pro Leu Ile Phe Pro Ala Thr Asp 
                565                 570                 575     


Ile Asp Arg Ile Leu Arg Ala Gly Phe Thr Leu Gln Glu Ala Leu Gly 
            580                 585                 590         


Ala Leu His Arg Val Gly Gly Asn Ala Asp Leu Ala Leu Leu Val Leu 
        595                 600                 605             


Leu Ala Lys Asn Ile Val Val Pro Thr 
    610                 615         


<210>  5470
<211>  508
<212>  DNA
<213>  Homosapiens

<400>  5470
ttccagagtc agccttagtt ttaaataaaa ctaataactg ttagacatct ggtggtatga     60

aaataaaaaa actaataact gtgtttctag actctaatgg gtatagccta aactgagata    120

agtgcagttt tcctttttac tcctaaagtg taagtaaggt aagattgttt catgggaagt    180

caatagcttc ctgaaacaat gctttgtctt ctcatgctgt taaccagtag tttattagaa    240

tgatttaaag ccttttgaat ataactgctt tgctgctttt taagatcaag ccctcttgtt    300

ggatgttaac atttagtact gagcatttga gttgcatctg tcctaataat agattgtatt    360

ttgaagtcat ttttgttact gaccttttga tttttatttt ttattattat tattttttat    420

tttgactgag tttcactctg tcacccaggc tggactcaga tggcgccatt gtactcctgt    480

ctgggcaaca agagcaaaac acagtctt                                       508


<210>  5471
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5471

Met Leu Thr Phe Ser Thr Glu His Leu Ser Cys Ile Cys Pro Asn Asn 
1               5                   10                  15      


Arg Leu Tyr Phe Glu Val Ile Phe Val Thr Asp Leu Leu Ile Phe Ile 
            20                  25                  30          


Phe Tyr Tyr Tyr Tyr Phe Leu Phe 
        35                  40  


<210>  5472
<211>  2906
<212>  DNA
<213>  Homosapiens

<400>  5472
caaaagaaga gctggaaatg atgtttaatg atactatgat gcttacactg agccgtcttg     60

tttgggtggt ctaaggtagc agtgaatcta aatagtcatt gccagttgaa aaactattaa    120

tgaaccatct ccctccacat tcccctttct ttaaaacatt taaatattct taacttagtt    180

gcacactatt gatgtgataa aaacttataa gccttttaag tttagagttg tattatttgg    240

taggatgatg attgtgattt aatctgctga tcattagttt acttttgttt tctgagtcag    300

atgctcaccc agttttacca tgatttttgg aaagcttggc tagaaataaa atagaacatt    360

tgcttctctg tccccaagca ttatgttatt tcttatttct ctttataatt ccctctctgt    420

ccaggtatac ctggtttaag acttctcatt tgtaacctca gtgttcacat ttgaaacaag    480

aaaagtgcat taacatgaga atcattctgg tgcaaagatt ctcaggattt gtaatatcct    540

taagaatcac ccaaggagct tattgaaaat gcacattcct ggatttactc tcaagtatgg    600

taccccaggg tctgcatact tcacaagcgt ccctggtggt tttagggcaa gtggtgaaaa    660

aagtacactt ggagaaacta ttctagagtt gtagactaga ctagggaata aagaaacata    720

aatgtccttc attcctgagc actaaccccg ccattatgtg aatgcatatt aatggatact    780

taatcacatt gaattacagt atgcagattt tattaagaac atgtctacct cttattctga    840

tgctgtgaat gtctaccaca atgagaaagt aattttaaaa tcatttctat ttgtgtaaga    900

gaaacccgag tttgaggacc ttattttatt ctacgctgtt tagatttgta tcctctggta    960

atttagtggc attagtcacc tgctaattaa tctttttcct ttcccctgtg ttccatatag   1020

agaaaagtgg taaagaatct acctcactgg gaatgtcatc attaccaact tcagatgggt   1080

ttaaccatcc cgcccgttct tcaggacaga gtcctgatgt tggtaatcct atgagtcttg   1140

ctcgctctgt ctctgcttca gtctgcccta tcaagcccag tgactcagat cgcattgaac   1200

ctaaagctgt gaaggctttg aaggcttcag ctgaattcca gctaaactct gaaaagaaag   1260

aacatctttc tttacaagat ctttctgatc atgcttcctc agcagaccat gctccaacag   1320

accagagtcc agctatgcct atgcagaatt catccgaaga aataactgtt gcaggtaatc   1380

tggagaaatc tgctgaaaga agcacccagg gcctcaaatt tcatctccat acaagacagg   1440

aagctagttt atctgtcaca tctactagga tgcatgaacc acagatgttt ctaggtgaaa   1500

aggattggca tccagaaaat cagaacctga gtcaagtgag tgaccctcag cagcacgaag   1560

aaccagggaa tgaacagtat gaggttgcac aacaaaaagc ttcacatgac caagaatatc   1620

tttgtaacat aggggacctt gagcttcctg aagaaaggca acagaatcaa cacaaaattg   1680

ttgatttgga agctacgatg aaaggaaatg ggctcccaca gaatgtggat cctccaagtg   1740

cgaagaaaag tattccatct tcagaatgca gtggctgctc aaattcagaa acatttatgg   1800

aaatcgatac agctcaacag tccctagtta ctttgcttaa ttcaacaggc aggcagaatg   1860

ccaatgtcaa gaacattggt gcattggatc tcactttaga taatcccttg atggaagtag   1920

aaacatcaaa atgtaaccct tcatctgaaa ttttgaatga ttccatttcc actcaggatt   1980

tacagccccc agaaactaat gttgaaatac ctggaacaaa taaagaatat ggccattact   2040

cctctccaag tctctgtggc agttgtcagc cttctgtgga gtcagcagaa gaatcttgcc   2100

cgtctataac ggcagccttg aaagaacttc atgaactttt ggttgttagc agtaaaccag   2160

cttcagaaaa tacatctgaa gaagtaatct gtcaatcaga aaccatagct gagggccaaa   2220

ccagtattaa agacctttct gaaagatgga cccaaaatga gcatcttacc cagaatgaac   2280

agtgtccaca agtctccttt catcaggcca tatctgtatc agtggagaca gaaaaattaa   2340

caggtacttc atctgacact ggaagagaag ctgtagaaaa tgtaaacttc aggagtctag   2400

gtgatggcct gtcaaccgat aaggaaggtg tccccaaatc tagggaatcc ataaataaga   2460

accgttctgt cactgtaacc tcagctaaaa catccaatca gttacactgc accttaggtg   2520

tagaaatttc acccaaactt ttagcaggtg aggaggatgc actcaatcag acttctgagc   2580

aaactaagtc tttgtcatcc aatttcatat tggttaaaga cttaggtcag ggcatacaga   2640

attcagtaac agacaggcct gaaaccagag aaaatgtctg tcctgatgct tcgaggccat   2700

tacttgaata tgaaccacct accagccatc catcatcaag tcctgccatt cttccaccat   2760

tgatttttcc tgccacagat attgaccgca ttctccgtgc tggctttact ttgcaggaag   2820

ctcttggagc tttgcatcga gttggtggga atgcagacct tgcacttctt gttttgctcg   2880

caaaaaacat cgtagttcct acatga                                        2906


<210>  5473
<211>  617
<212>  PRT
<213>  Homosapiens

<400>  5473

Met Ser Ser Leu Pro Thr Ser Asp Gly Phe Asn His Pro Ala Arg Ser 
1               5                   10                  15      


Ser Gly Gln Ser Pro Asp Val Gly Asn Pro Met Ser Leu Ala Arg Ser 
            20                  25                  30          


Val Ser Ala Ser Val Cys Pro Ile Lys Pro Ser Asp Ser Asp Arg Ile 
        35                  40                  45              


Glu Pro Lys Ala Val Lys Ala Leu Lys Ala Ser Ala Glu Phe Gln Leu 
    50                  55                  60                  


Asn Ser Glu Lys Lys Glu His Leu Ser Leu Gln Asp Leu Ser Asp His 
65                  70                  75                  80  


Ala Ser Ser Ala Asp His Ala Pro Thr Asp Gln Ser Pro Ala Met Pro 
                85                  90                  95      


Met Gln Asn Ser Ser Glu Glu Ile Thr Val Ala Gly Asn Leu Glu Lys 
            100                 105                 110         


Ser Ala Glu Arg Ser Thr Gln Gly Leu Lys Phe His Leu His Thr Arg 
        115                 120                 125             


Gln Glu Ala Ser Leu Ser Val Thr Ser Thr Arg Met His Glu Pro Gln 
    130                 135                 140                 


Met Phe Leu Gly Glu Lys Asp Trp His Pro Glu Asn Gln Asn Leu Ser 
145                 150                 155                 160 


Gln Val Ser Asp Pro Gln Gln His Glu Glu Pro Gly Asn Glu Gln Tyr 
                165                 170                 175     


Glu Val Ala Gln Gln Lys Ala Ser His Asp Gln Glu Tyr Leu Cys Asn 
            180                 185                 190         


Ile Gly Asp Leu Glu Leu Pro Glu Glu Arg Gln Gln Asn Gln His Lys 
        195                 200                 205             


Ile Val Asp Leu Glu Ala Thr Met Lys Gly Asn Gly Leu Pro Gln Asn 
    210                 215                 220                 


Val Asp Pro Pro Ser Ala Lys Lys Ser Ile Pro Ser Ser Glu Cys Ser 
225                 230                 235                 240 


Gly Cys Ser Asn Ser Glu Thr Phe Met Glu Ile Asp Thr Ala Gln Gln 
                245                 250                 255     


Ser Leu Val Thr Leu Leu Asn Ser Thr Gly Arg Gln Asn Ala Asn Val 
            260                 265                 270         


Lys Asn Ile Gly Ala Leu Asp Leu Thr Leu Asp Asn Pro Leu Met Glu 
        275                 280                 285             


Val Glu Thr Ser Lys Cys Asn Pro Ser Ser Glu Ile Leu Asn Asp Ser 
    290                 295                 300                 


Ile Ser Thr Gln Asp Leu Gln Pro Pro Glu Thr Asn Val Glu Ile Pro 
305                 310                 315                 320 


Gly Thr Asn Lys Glu Tyr Gly His Tyr Ser Ser Pro Ser Leu Cys Gly 
                325                 330                 335     


Ser Cys Gln Pro Ser Val Glu Ser Ala Glu Glu Ser Cys Pro Ser Ile 
            340                 345                 350         


Thr Ala Ala Leu Lys Glu Leu His Glu Leu Leu Val Val Ser Ser Lys 
        355                 360                 365             


Pro Ala Ser Glu Asn Thr Ser Glu Glu Val Ile Cys Gln Ser Glu Thr 
    370                 375                 380                 


Ile Ala Glu Gly Gln Thr Ser Ile Lys Asp Leu Ser Glu Arg Trp Thr 
385                 390                 395                 400 


Gln Asn Glu His Leu Thr Gln Asn Glu Gln Cys Pro Gln Val Ser Phe 
                405                 410                 415     


His Gln Ala Ile Ser Val Ser Val Glu Thr Glu Lys Leu Thr Gly Thr 
            420                 425                 430         


Ser Ser Asp Thr Gly Arg Glu Ala Val Glu Asn Val Asn Phe Arg Ser 
        435                 440                 445             


Leu Gly Asp Gly Leu Ser Thr Asp Lys Glu Gly Val Pro Lys Ser Arg 
    450                 455                 460                 


Glu Ser Ile Asn Lys Asn Arg Ser Val Thr Val Thr Ser Ala Lys Thr 
465                 470                 475                 480 


Ser Asn Gln Leu His Cys Thr Leu Gly Val Glu Ile Ser Pro Lys Leu 
                485                 490                 495     


Leu Ala Gly Glu Glu Asp Ala Leu Asn Gln Thr Ser Glu Gln Thr Lys 
            500                 505                 510         


Ser Leu Ser Ser Asn Phe Ile Leu Val Lys Asp Leu Gly Gln Gly Ile 
        515                 520                 525             


Gln Asn Ser Val Thr Asp Arg Pro Glu Thr Arg Glu Asn Val Cys Pro 
    530                 535                 540                 


Asp Ala Ser Arg Pro Leu Leu Glu Tyr Glu Pro Pro Thr Ser His Pro 
545                 550                 555                 560 


Ser Ser Ser Pro Ala Ile Leu Pro Pro Leu Ile Phe Pro Ala Thr Asp 
                565                 570                 575     


Ile Asp Arg Ile Leu Arg Ala Gly Phe Thr Leu Gln Glu Ala Leu Gly 
            580                 585                 590         


Ala Leu His Arg Val Gly Gly Asn Ala Asp Leu Ala Leu Leu Val Leu 
        595                 600                 605             


Leu Ala Lys Asn Ile Val Val Pro Thr 
    610                 615         


<210>  5474
<211>  4033
<212>  DNA
<213>  Homosapiens

<400>  5474
atggcctgct attcaacagc agagaagaat cccaaagctt gttggcggtt ggcggcggcc     60

cccggccccc ggcgcgggaa gcggcggcgg ggcggcggcg gcggtggcgg tggcggtggc    120

ggcgacggtg gcagcgccat ggagccgggg gaggtgaagg accggatcct ggagaacatc    180

tcgctgtcgg tgaagaagtt gcagagctat tttgctgcat gtgaggatga gatccctgcc    240

atccggaacc atgacaaggt cctacagcgt ctgtgtgagc acctggacca cgccctgctg    300

tacggactgc aagacctctc ctctggctac tgggtgctcg tggtgcattt tactcggaga    360

gaggccatca agcagatcga ggtgctgcag cacgtggcca ccaacctggg gcgcagccgt    420

gcctggctgt acctggccct caacgagaac tccttggaga gctacctgcg gttgttccag    480

gagaacctgg gcctgctgca taagtactac gtcaagaatg ccctggtctg cagccacgat    540

cacctgacgc tcttcctgac cttggtgtcc gggctagagt tcattcgttt cgagctggat    600

ctggatgccc cttacctaga cctggccccc tacatgcccg actactacaa acctcagtac    660

ctgctggact ttgaagaccg ccttcccagc tcggtccacg gctcagacag tctgtccctc    720

aactctttca actccgtcac ctccaccaac ctggagtggg atgacagtgc gattgcccca    780

tctagtgagg attatgattt tggagatgtg tttccagcag tgccgtctgt acccagcaca    840

gactgggaag atggagacct cacagacacg gtcagtggtc cccgctccac agcctccgac    900

ctgaccagca gcaaggcctc caccaggagc cccacccagc gccagaaccc cttcaacgag    960

gagccggcag agactgtgtc ctcctctgac accacccccg tgcacaccac ctctcaggag   1020

aaggaggagg cccaggccct ggacccgccg gatgcctgca cggagctcga ggtcatcagg   1080

gtcaccaaga agaagaaaat tggcaagaag aaaaagagca gatcagatga ggaggcaagt   1140

ccactccacc ccgcctgcag ccagaagaaa tgtgccaagc agggggacgg tgacagccgc   1200

aacggcagcc caagccttgg gcgggactcg ccagacacta tgcttgcctc cccccaggag   1260

gagggagagg ggccgagcag caccacggag agcagcgagc gctccgagcc gggcctgctg   1320

atccctgaga tgaaggacac ctccatggag cgcttggggc agcccctgag caaggttatc   1380

gaccagctca acgggcagct ggaccccagc acctggtgct cccgtgctga gcccccagac   1440

cagtcctttc ggaccggctc tcccggggat gccccggaga ggccgccgct ttgcgacttt   1500

agtgaggggc tttcagcccc aatggacttc taccgcttta ccgtcgagag tccaagcact   1560

gttacatcag gtggcggcca ccatgaccct gcagggcttg gccaaccgct gcatgttcct   1620

agtagccctg aggctgctgg ccaagaagaa gagggaggag gaggagaggg acagacgcct   1680

cggcccctag aggataccac gagggaggct caggagctgg aggcccagct gtccctggtc   1740

agggaggggc ctgtgtctga gccagagcct gggacccagg aggttctctg ccagctcaag   1800

cgagaccagc ccagcccgtg tctgagtagc gctgaggatt ctggggtgga tgagggacag   1860

gggagccctt cggagatggt ccattcctcg gagttcagag tagacaacaa tcacctgctc   1920

ctgctcatga tccacgtgtt ccgagaaaac gaagagcagc tgttcaaaat gatccggatg   1980

agcaccgggc acatggaggg caacctgcag ctgctgtacg tgctgctcac agactgctat   2040

gtctacctgc tccggaaagg ggccacagag aagccatacc tggtggaaga ggccgtttct   2100

tacaatgaac ttgactatgt gtcggttggc cttgaccagc agacggtgaa gctggtgtgc   2160

accaaccgca ggaagcagtt tctgctggac acggctgatg tggcgctggc tgagttcttt   2220

ttggcttctt tgaagtcagc catgatcaaa ggctgtcgag aacctcccta ccccagcatc   2280

ctgacggatg ccaccatgga gaagctggca ctggccaaat ttgtggccca agaatcgaag   2340

tgtgaggcat ctgctgtcac cgtgcgcttc tacggccttg tgcactggga ggaccccaca   2400

gacgagtccc tgggccccac gccctgccac tgctcacccc ccgagggcac catcaccaaa   2460

gaaggcatgc tgcactacaa ggcgggcacc tcctacctgg gcaaggaaca ctggaagacg   2520

tgcttcgtgg tgctcagcaa cgggatcctc taccagtacc cggaccgcac cgacgtcatc   2580

cctctgctct cggtgaacat ggggggggag cagtgcggtg gctgccggag agccaacacc   2640

acggatcggc cccacgcctt ccaggtcatt ctctccgacc ggccctgcct ggagctaagt   2700

gccgagagcg aggccgagat ggccgagtgg atgcagcatc tctgccaggc tgtgtccaaa   2760

ggggtcatcc cccagggcgt agctcccagc ccctgcatac cctgctgcct ggtcctcacg   2820

gatgaccgcc tctttacgtg ccatgaggat tgccagacca gcttcttccg ctctttgggc   2880

acagccaagc tgggcgacat cagcgccgtc tccaccgagc cgggcaagga gtactgcgtc   2940

ttggagttct cccaggacag ccagcagctc ctcccgccct gggtcatcta cctgagctgc   3000

acttctgaac tggaccgatt gctgtctgca ctgaactctg ggtggaaaac catctatcag   3060

gtggacctcc cccacacggc gatccaggaa gcctccaaca agaagaaatt cgaggatgcc   3120

ttgagcctca tccacagcgc ctggcagcgg agcgacagtc tctgccgcgg ccgagcctcc   3180

cgagacccct ggtgctgagg cagagctggt tggcgtccct ggtgggcagg aaaggaaggc   3240

acgccagccg gcaggcacac tgtcacggct gttgtcatgc tgtcgggagc ctacagtcca   3300

cccctgccct gggcggcaga accaccgagt gtggcttaag acagggtccc tccactccag   3360

ggatccagat caggtgcccg gcacccctgg gcatcctgcc cgacaggtag cgaatggagg   3420

tcgctggggg cagagggtcc gagccctgtg ggctctgcgg atgcacgccc tcctcccggg   3480

cctccgcctc agtctgcaga atttctgccg agtggcaccg agaacaccat ccatctaagg   3540

acgaacaaaa gaaccaggag ggcgggaccc ccctcttcct ctcctgggtt gggggctggg   3600

gccctgagtg cccagccatc cttgttcgtg tttgaacact ctcctggcca cgtggggaag   3660

cgggaacacg gggtgtctgc gcatgtttcc tcctcctagc tccatcactg cgcacacagc   3720

tgcctgcctc gccagatgca ggggggcggg cagccctccc tggctgccag gaggctctgc   3780

atgcccacag tcctgccctg cctgtcccct caacccggca gtgcctgtag caccgaggag   3840

caaagggggt ggatgggggg cttggagaag ggcggagccc accagcctgg catccatgtt   3900

gacatcttct gactgtcccc tgcttggctg gagccaggcc cttccctaga gtttcgtcaa   3960

gagcctcctg gggaaggggt caggtggttt gggttttgtt ttttaaaata aaatagacat   4020

gttatattgc caa                                                      4033


<210>  5475
<211>  1065
<212>  PRT
<213>  Homosapiens

<400>  5475

Met Ala Cys Tyr Ser Thr Ala Glu Lys Asn Pro Lys Ala Cys Trp Arg 
1               5                   10                  15      


Leu Ala Ala Ala Pro Gly Pro Arg Arg Gly Lys Arg Arg Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Asp Gly Gly Ser Ala Met Glu 
        35                  40                  45              


Pro Gly Glu Val Lys Asp Arg Ile Leu Glu Asn Ile Ser Leu Ser Val 
    50                  55                  60                  


Lys Lys Leu Gln Ser Tyr Phe Ala Ala Cys Glu Asp Glu Ile Pro Ala 
65                  70                  75                  80  


Ile Arg Asn His Asp Lys Val Leu Gln Arg Leu Cys Glu His Leu Asp 
                85                  90                  95      


His Ala Leu Leu Tyr Gly Leu Gln Asp Leu Ser Ser Gly Tyr Trp Val 
            100                 105                 110         


Leu Val Val His Phe Thr Arg Arg Glu Ala Ile Lys Gln Ile Glu Val 
        115                 120                 125             


Leu Gln His Val Ala Thr Asn Leu Gly Arg Ser Arg Ala Trp Leu Tyr 
    130                 135                 140                 


Leu Ala Leu Asn Glu Asn Ser Leu Glu Ser Tyr Leu Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Leu Gly Leu Leu His Lys Tyr Tyr Val Lys Asn Ala Leu Val 
                165                 170                 175     


Cys Ser His Asp His Leu Thr Leu Phe Leu Thr Leu Val Ser Gly Leu 
            180                 185                 190         


Glu Phe Ile Arg Phe Glu Leu Asp Leu Asp Ala Pro Tyr Leu Asp Leu 
        195                 200                 205             


Ala Pro Tyr Met Pro Asp Tyr Tyr Lys Pro Gln Tyr Leu Leu Asp Phe 
    210                 215                 220                 


Glu Asp Arg Leu Pro Ser Ser Val His Gly Ser Asp Ser Leu Ser Leu 
225                 230                 235                 240 


Asn Ser Phe Asn Ser Val Thr Ser Thr Asn Leu Glu Trp Asp Asp Ser 
                245                 250                 255     


Ala Ile Ala Pro Ser Ser Glu Asp Tyr Asp Phe Gly Asp Val Phe Pro 
            260                 265                 270         


Ala Val Pro Ser Val Pro Ser Thr Asp Trp Glu Asp Gly Asp Leu Thr 
        275                 280                 285             


Asp Thr Val Ser Gly Pro Arg Ser Thr Ala Ser Asp Leu Thr Ser Ser 
    290                 295                 300                 


Lys Ala Ser Thr Arg Ser Pro Thr Gln Arg Gln Asn Pro Phe Asn Glu 
305                 310                 315                 320 


Glu Pro Ala Glu Thr Val Ser Ser Ser Asp Thr Thr Pro Val His Thr 
                325                 330                 335     


Thr Ser Gln Glu Lys Glu Glu Ala Gln Ala Leu Asp Pro Pro Asp Ala 
            340                 345                 350         


Cys Thr Glu Leu Glu Val Ile Arg Val Thr Lys Lys Lys Lys Ile Gly 
        355                 360                 365             


Lys Lys Lys Lys Ser Arg Ser Asp Glu Glu Ala Ser Pro Leu His Pro 
    370                 375                 380                 


Ala Cys Ser Gln Lys Lys Cys Ala Lys Gln Gly Asp Gly Asp Ser Arg 
385                 390                 395                 400 


Asn Gly Ser Pro Ser Leu Gly Arg Asp Ser Pro Asp Thr Met Leu Ala 
                405                 410                 415     


Ser Pro Gln Glu Glu Gly Glu Gly Pro Ser Ser Thr Thr Glu Ser Ser 
            420                 425                 430         


Glu Arg Ser Glu Pro Gly Leu Leu Ile Pro Glu Met Lys Asp Thr Ser 
        435                 440                 445             


Met Glu Arg Leu Gly Gln Pro Leu Ser Lys Val Ile Asp Gln Leu Asn 
    450                 455                 460                 


Gly Gln Leu Asp Pro Ser Thr Trp Cys Ser Arg Ala Glu Pro Pro Asp 
465                 470                 475                 480 


Gln Ser Phe Arg Thr Gly Ser Pro Gly Asp Ala Pro Glu Arg Pro Pro 
                485                 490                 495     


Leu Cys Asp Phe Ser Glu Gly Leu Ser Ala Pro Met Asp Phe Tyr Arg 
            500                 505                 510         


Phe Thr Val Glu Ser Pro Ser Thr Val Thr Ser Gly Gly Gly His His 
        515                 520                 525             


Asp Pro Ala Gly Leu Gly Gln Pro Leu His Val Pro Ser Ser Pro Glu 
    530                 535                 540                 


Ala Ala Gly Gln Glu Glu Glu Gly Gly Gly Gly Glu Gly Gln Thr Pro 
545                 550                 555                 560 


Arg Pro Leu Glu Asp Thr Thr Arg Glu Ala Gln Glu Leu Glu Ala Gln 
                565                 570                 575     


Leu Ser Leu Val Arg Glu Gly Pro Val Ser Glu Pro Glu Pro Gly Thr 
            580                 585                 590         


Gln Glu Val Leu Cys Gln Leu Lys Arg Asp Gln Pro Ser Pro Cys Leu 
        595                 600                 605             


Ser Ser Ala Glu Asp Ser Gly Val Asp Glu Gly Gln Gly Ser Pro Ser 
    610                 615                 620                 


Glu Met Val His Ser Ser Glu Phe Arg Val Asp Asn Asn His Leu Leu 
625                 630                 635                 640 


Leu Leu Met Ile His Val Phe Arg Glu Asn Glu Glu Gln Leu Phe Lys 
                645                 650                 655     


Met Ile Arg Met Ser Thr Gly His Met Glu Gly Asn Leu Gln Leu Leu 
            660                 665                 670         


Tyr Val Leu Leu Thr Asp Cys Tyr Val Tyr Leu Leu Arg Lys Gly Ala 
        675                 680                 685             


Thr Glu Lys Pro Tyr Leu Val Glu Glu Ala Val Ser Tyr Asn Glu Leu 
    690                 695                 700                 


Asp Tyr Val Ser Val Gly Leu Asp Gln Gln Thr Val Lys Leu Val Cys 
705                 710                 715                 720 


Thr Asn Arg Arg Lys Gln Phe Leu Leu Asp Thr Ala Asp Val Ala Leu 
                725                 730                 735     


Ala Glu Phe Phe Leu Ala Ser Leu Lys Ser Ala Met Ile Lys Gly Cys 
            740                 745                 750         


Arg Glu Pro Pro Tyr Pro Ser Ile Leu Thr Asp Ala Thr Met Glu Lys 
        755                 760                 765             


Leu Ala Leu Ala Lys Phe Val Ala Gln Glu Ser Lys Cys Glu Ala Ser 
    770                 775                 780                 


Ala Val Thr Val Arg Phe Tyr Gly Leu Val His Trp Glu Asp Pro Thr 
785                 790                 795                 800 


Asp Glu Ser Leu Gly Pro Thr Pro Cys His Cys Ser Pro Pro Glu Gly 
                805                 810                 815     


Thr Ile Thr Lys Glu Gly Met Leu His Tyr Lys Ala Gly Thr Ser Tyr 
            820                 825                 830         


Leu Gly Lys Glu His Trp Lys Thr Cys Phe Val Val Leu Ser Asn Gly 
        835                 840                 845             


Ile Leu Tyr Gln Tyr Pro Asp Arg Thr Asp Val Ile Pro Leu Leu Ser 
    850                 855                 860                 


Val Asn Met Gly Gly Glu Gln Cys Gly Gly Cys Arg Arg Ala Asn Thr 
865                 870                 875                 880 


Thr Asp Arg Pro His Ala Phe Gln Val Ile Leu Ser Asp Arg Pro Cys 
                885                 890                 895     


Leu Glu Leu Ser Ala Glu Ser Glu Ala Glu Met Ala Glu Trp Met Gln 
            900                 905                 910         


His Leu Cys Gln Ala Val Ser Lys Gly Val Ile Pro Gln Gly Val Ala 
        915                 920                 925             


Pro Ser Pro Cys Ile Pro Cys Cys Leu Val Leu Thr Asp Asp Arg Leu 
    930                 935                 940                 


Phe Thr Cys His Glu Asp Cys Gln Thr Ser Phe Phe Arg Ser Leu Gly 
945                 950                 955                 960 


Thr Ala Lys Leu Gly Asp Ile Ser Ala Val Ser Thr Glu Pro Gly Lys 
                965                 970                 975     


Glu Tyr Cys Val Leu Glu Phe Ser Gln Asp Ser Gln Gln Leu Leu Pro 
            980                 985                 990         


Pro Trp Val Ile Tyr Leu Ser Cys  Thr Ser Glu Leu Asp  Arg Leu Leu 
        995                 1000                 1005             


Ser Ala  Leu Asn Ser Gly Trp  Lys Thr Ile Tyr Gln  Val Asp Leu 
    1010                 1015                 1020             


Pro His  Thr Ala Ile Gln Glu  Ala Ser Asn Lys Lys  Lys Phe Glu 
    1025                 1030                 1035             


Asp Ala  Leu Ser Leu Ile His  Ser Ala Trp Gln Arg  Ser Asp Ser 
    1040                 1045                 1050             


Leu Cys  Arg Gly Arg Ala Ser  Arg Asp Pro Trp Cys  
    1055                 1060                 1065 


<210>  5476
<211>  4122
<212>  DNA
<213>  Homosapiens

<400>  5476
gcctccttcc ccgccggccg cgctccggag cctccgggcc gcggtggagc gagggcccag     60

gcgaggcgag ggccgggcgg cgggcgccgg gccccgcggc cggcacgacg gagcccccgt    120

acggccggcg gcagcggttg gcggcggccc ccggcccccg gcgcgggaag cggcggcggg    180

gcggcggcgg cggtggcggt ggcggtggcg gcgacggtgg cagcgccatg gagccggggg    240

aggtgaagga ccggatcctg gagaacatct cgctgtcggt gaagaagttg cagagctatt    300

ttgctgcatg tgaggatgag atccctgcca tccggaacca tgacaaggtc ctacagcgtc    360

tgtgtgagca cctggaccac gccctgctgt acggactgca agacctctcc tctggctact    420

gggtgctcgt ggtgcatttt actcggagag aggccatcaa gcagatcgag gtgctgcagc    480

acgtggccac caacctgggg cgcagccgtg cctggctgta cctggccctc aacgagaact    540

ccttggagag ctacctgcgg ttgttccagg agaacctggg cctgctgcat aagtactacg    600

tcaagaatgc cctggtctgc agccacgatc acctgacgct cttcctgacc ttggtgtccg    660

ggctagagtt cattcgtttc gagctggatc tggatgcccc ttacctagac ctggccccct    720

acatgcccga ctactacaaa cctcagtacc tgctggactt tgaagaccgc cttcccagct    780

cggtccacgg ctcagacagt ctgtccctca actctttcaa ctccgtcacc tccaccaacc    840

tggagtggga tgacagtgcg attgccccat ctagtgagga ttatgatttt ggagatgtgt    900

ttccagcagt gccgtctgta cccagcacag actgggaaga tggagacctc acagacacgg    960

tcagtggtcc ccgctccaca gcctccgacc tgaccagcag caaggcctcc accaggagcc   1020

ccacccagcg ccagaacccc ttcaacgagg agccggcaga gactgtgtcc tcctctgaca   1080

ccacccccgt gcacaccacc tctcaggaga aggaggaggc ccaggccctg gacccgccgg   1140

atgcctgcac ggagctcgag gtcatcaggg tcaccaagaa gaagaaaatt ggcaagaaga   1200

aaaagagcag atcagatgag gaggcaagtc cactccaccc cgcctgcagc cagaagaaat   1260

gtgccaagca gggggacggt gacagccgca acggcagccc aagccttggg cgggactcgc   1320

cagacactat gcttgcctcc ccccaggagg agggagaggg gccgagcagc accacggaga   1380

gcagcgagcg ctccgagccg ggcctgctga tccctgagat gaaggacacc tccatggagc   1440

gcttggggca gcccctgagc aaggttatcg accagctcaa cgggcagctg gaccccagca   1500

cctggtgctc ccgtgctgag cccccagacc agtcctttcg gaccggctct cccggggatg   1560

ccccggagag gccgccgctt tgcgacttta gtgaggggct ttcagcccca atggacttct   1620

accgctttac cgtcgagagt ccaagcactg ttacatcagg tggcggccac catgaccctg   1680

cagggcttgg ccaaccgctg catgttccta gtagccctga ggctgctggc caagaagaag   1740

agggaggagg aggagaggga cagacgcctc ggcccctaga ggataccacg agggaggctc   1800

aggagctgga ggcccagctg tccctggtca gggaggggcc tgtgtctgag ccagagcctg   1860

ggacccagga ggttctctgc cagctcaagc gagaccagcc cagcccgtgt ctgagtagcg   1920

ctgaggattc tggggtggat gagggacagg ggagcccttc ggagatggtc cattcctcgg   1980

agttcagagt agacaacaat cacctgctcc tgctcatgat ccacgtgttc cgagaaaacg   2040

aagagcagct gttcaaaatg atccggatga gcaccgggca catggagggc aacctgcagc   2100

tgctgtacgt gctgctcaca gactgctatg tctacctgct ccggaaaggg gccacagaga   2160

agccatacct ggtggaagag gccgtttctt acaatgaact tgactatgtg tcggttggcc   2220

ttgaccagca gacggtgaag ctggtgtgca ccaaccgcag gaagcagttt ctgctggaca   2280

cggctgatgt ggcgctggct gagttctttt tggcttcttt gaagtcagcc atgatcaaag   2340

gctgtcgaga acctccctac cccagcatcc tgacggatgc caccatggag aagctggcac   2400

tggccaaatt tgtggcccaa gaatcgaagt gtgaggcatc tgctgtcacc gtgcgcttct   2460

acggccttgt gcactgggag gaccccacag acgagtccct gggccccacg ccctgccact   2520

gctcaccccc cgagggcacc atcaccaaag aaggcatgct gcactacaag gcgggcacct   2580

cctacctggg caaggaacac tggaagacgt gcttcgtggt gctcagcaac gggatcctct   2640

accagtaccc ggaccgcacc gacgtcatcc ctctgctctc ggtgaacatg gggggggagc   2700

agtgcggtgg ctgccggaga gccaacacca cggatcggcc ccacgccttc caggtcattc   2760

tctccgaccg gccctgcctg gagctaagtg ccgagagcga ggccgagatg gccgagtgga   2820

tgcagcatct ctgccaggct gtgtccaaag gggtcatccc ccagggcgta gctcccagcc   2880

cctgcatacc ctgctgcctg gtcctcacgg atgaccgcct ctttacgtgc catgaggatt   2940

gccagaccag cttcttccgc tctttgggca cagccaagct gggcgacatc agcgccgtct   3000

ccaccgagcc gggcaaggag tactgcgtct tggagttctc ccaggacagc cagcagctcc   3060

tcccgccctg ggtcatctac ctgagctgca cttctgaact ggaccgattg ctgtctgcac   3120

tgaactctgg gtggaaaacc atctatcagg tggacctccc ccacacggcg atccaggaag   3180

cctccaacaa gaagaaattc gaggatgcct tgagcctcat ccacagcgcc tggcagcgga   3240

gcgacagtct ctgccgcggc cgagcctccc gagacccctg gtgctgaggc agagctggtt   3300

ggcgtccctg gtgggcagga aaggaaggca cgccagccgg caggcacact gtcacggctg   3360

ttgtcatgct gtcgggagcc tacagtccac ccctgccctg ggcggcagaa ccaccgagtg   3420

tggcttaaga cagggtccct ccactccagg gatccagatc aggtgcccgg cacccctggg   3480

catcctgccc gacaggtagc gaatggaggt cgctgggggc agagggtccg agccctgtgg   3540

gctctgcgga tgcacgccct cctcccgggc ctccgcctca gtctgcagaa tttctgccga   3600

gtggcaccga gaacaccatc catctaagga cgaacaaaag aaccaggagg gcgggacccc   3660

cctcttcctc tcctgggttg ggggctgggg ccctgagtgc ccagccatcc ttgttcgtgt   3720

ttgaacactc tcctggccac gtggggaagc gggaacacgg ggtgtctgcg catgtttcct   3780

cctcctagct ccatcactgc gcacacagct gcctgcctcg ccagatgcag gggggcgggc   3840

agccctccct ggctgccagg aggctctgca tgcccacagt cctgccctgc ctgtcccctc   3900

aacccggcag tgcctgtagc accgaggagc aaagggggtg gatggggggc ttggagaagg   3960

gcggagccca ccagcctggc atccatgttg acatcttctg actgtcccct gcttggctgg   4020

agccaggccc ttccctagag tttcgtcaag agcctcctgg ggaaggggtc aggtggtttg   4080

ggttttgttt tttaaaataa aatagacatg ttatattgcc aa                      4122


<210>  5477
<211>  1019
<212>  PRT
<213>  Homosapiens

<400>  5477

Met Glu Pro Gly Glu Val Lys Asp Arg Ile Leu Glu Asn Ile Ser Leu 
1               5                   10                  15      


Ser Val Lys Lys Leu Gln Ser Tyr Phe Ala Ala Cys Glu Asp Glu Ile 
            20                  25                  30          


Pro Ala Ile Arg Asn His Asp Lys Val Leu Gln Arg Leu Cys Glu His 
        35                  40                  45              


Leu Asp His Ala Leu Leu Tyr Gly Leu Gln Asp Leu Ser Ser Gly Tyr 
    50                  55                  60                  


Trp Val Leu Val Val His Phe Thr Arg Arg Glu Ala Ile Lys Gln Ile 
65                  70                  75                  80  


Glu Val Leu Gln His Val Ala Thr Asn Leu Gly Arg Ser Arg Ala Trp 
                85                  90                  95      


Leu Tyr Leu Ala Leu Asn Glu Asn Ser Leu Glu Ser Tyr Leu Arg Leu 
            100                 105                 110         


Phe Gln Glu Asn Leu Gly Leu Leu His Lys Tyr Tyr Val Lys Asn Ala 
        115                 120                 125             


Leu Val Cys Ser His Asp His Leu Thr Leu Phe Leu Thr Leu Val Ser 
    130                 135                 140                 


Gly Leu Glu Phe Ile Arg Phe Glu Leu Asp Leu Asp Ala Pro Tyr Leu 
145                 150                 155                 160 


Asp Leu Ala Pro Tyr Met Pro Asp Tyr Tyr Lys Pro Gln Tyr Leu Leu 
                165                 170                 175     


Asp Phe Glu Asp Arg Leu Pro Ser Ser Val His Gly Ser Asp Ser Leu 
            180                 185                 190         


Ser Leu Asn Ser Phe Asn Ser Val Thr Ser Thr Asn Leu Glu Trp Asp 
        195                 200                 205             


Asp Ser Ala Ile Ala Pro Ser Ser Glu Asp Tyr Asp Phe Gly Asp Val 
    210                 215                 220                 


Phe Pro Ala Val Pro Ser Val Pro Ser Thr Asp Trp Glu Asp Gly Asp 
225                 230                 235                 240 


Leu Thr Asp Thr Val Ser Gly Pro Arg Ser Thr Ala Ser Asp Leu Thr 
                245                 250                 255     


Ser Ser Lys Ala Ser Thr Arg Ser Pro Thr Gln Arg Gln Asn Pro Phe 
            260                 265                 270         


Asn Glu Glu Pro Ala Glu Thr Val Ser Ser Ser Asp Thr Thr Pro Val 
        275                 280                 285             


His Thr Thr Ser Gln Glu Lys Glu Glu Ala Gln Ala Leu Asp Pro Pro 
    290                 295                 300                 


Asp Ala Cys Thr Glu Leu Glu Val Ile Arg Val Thr Lys Lys Lys Lys 
305                 310                 315                 320 


Ile Gly Lys Lys Lys Lys Ser Arg Ser Asp Glu Glu Ala Ser Pro Leu 
                325                 330                 335     


His Pro Ala Cys Ser Gln Lys Lys Cys Ala Lys Gln Gly Asp Gly Asp 
            340                 345                 350         


Ser Arg Asn Gly Ser Pro Ser Leu Gly Arg Asp Ser Pro Asp Thr Met 
        355                 360                 365             


Leu Ala Ser Pro Gln Glu Glu Gly Glu Gly Pro Ser Ser Thr Thr Glu 
    370                 375                 380                 


Ser Ser Glu Arg Ser Glu Pro Gly Leu Leu Ile Pro Glu Met Lys Asp 
385                 390                 395                 400 


Thr Ser Met Glu Arg Leu Gly Gln Pro Leu Ser Lys Val Ile Asp Gln 
                405                 410                 415     


Leu Asn Gly Gln Leu Asp Pro Ser Thr Trp Cys Ser Arg Ala Glu Pro 
            420                 425                 430         


Pro Asp Gln Ser Phe Arg Thr Gly Ser Pro Gly Asp Ala Pro Glu Arg 
        435                 440                 445             


Pro Pro Leu Cys Asp Phe Ser Glu Gly Leu Ser Ala Pro Met Asp Phe 
    450                 455                 460                 


Tyr Arg Phe Thr Val Glu Ser Pro Ser Thr Val Thr Ser Gly Gly Gly 
465                 470                 475                 480 


His His Asp Pro Ala Gly Leu Gly Gln Pro Leu His Val Pro Ser Ser 
                485                 490                 495     


Pro Glu Ala Ala Gly Gln Glu Glu Glu Gly Gly Gly Gly Glu Gly Gln 
            500                 505                 510         


Thr Pro Arg Pro Leu Glu Asp Thr Thr Arg Glu Ala Gln Glu Leu Glu 
        515                 520                 525             


Ala Gln Leu Ser Leu Val Arg Glu Gly Pro Val Ser Glu Pro Glu Pro 
    530                 535                 540                 


Gly Thr Gln Glu Val Leu Cys Gln Leu Lys Arg Asp Gln Pro Ser Pro 
545                 550                 555                 560 


Cys Leu Ser Ser Ala Glu Asp Ser Gly Val Asp Glu Gly Gln Gly Ser 
                565                 570                 575     


Pro Ser Glu Met Val His Ser Ser Glu Phe Arg Val Asp Asn Asn His 
            580                 585                 590         


Leu Leu Leu Leu Met Ile His Val Phe Arg Glu Asn Glu Glu Gln Leu 
        595                 600                 605             


Phe Lys Met Ile Arg Met Ser Thr Gly His Met Glu Gly Asn Leu Gln 
    610                 615                 620                 


Leu Leu Tyr Val Leu Leu Thr Asp Cys Tyr Val Tyr Leu Leu Arg Lys 
625                 630                 635                 640 


Gly Ala Thr Glu Lys Pro Tyr Leu Val Glu Glu Ala Val Ser Tyr Asn 
                645                 650                 655     


Glu Leu Asp Tyr Val Ser Val Gly Leu Asp Gln Gln Thr Val Lys Leu 
            660                 665                 670         


Val Cys Thr Asn Arg Arg Lys Gln Phe Leu Leu Asp Thr Ala Asp Val 
        675                 680                 685             


Ala Leu Ala Glu Phe Phe Leu Ala Ser Leu Lys Ser Ala Met Ile Lys 
    690                 695                 700                 


Gly Cys Arg Glu Pro Pro Tyr Pro Ser Ile Leu Thr Asp Ala Thr Met 
705                 710                 715                 720 


Glu Lys Leu Ala Leu Ala Lys Phe Val Ala Gln Glu Ser Lys Cys Glu 
                725                 730                 735     


Ala Ser Ala Val Thr Val Arg Phe Tyr Gly Leu Val His Trp Glu Asp 
            740                 745                 750         


Pro Thr Asp Glu Ser Leu Gly Pro Thr Pro Cys His Cys Ser Pro Pro 
        755                 760                 765             


Glu Gly Thr Ile Thr Lys Glu Gly Met Leu His Tyr Lys Ala Gly Thr 
    770                 775                 780                 


Ser Tyr Leu Gly Lys Glu His Trp Lys Thr Cys Phe Val Val Leu Ser 
785                 790                 795                 800 


Asn Gly Ile Leu Tyr Gln Tyr Pro Asp Arg Thr Asp Val Ile Pro Leu 
                805                 810                 815     


Leu Ser Val Asn Met Gly Gly Glu Gln Cys Gly Gly Cys Arg Arg Ala 
            820                 825                 830         


Asn Thr Thr Asp Arg Pro His Ala Phe Gln Val Ile Leu Ser Asp Arg 
        835                 840                 845             


Pro Cys Leu Glu Leu Ser Ala Glu Ser Glu Ala Glu Met Ala Glu Trp 
    850                 855                 860                 


Met Gln His Leu Cys Gln Ala Val Ser Lys Gly Val Ile Pro Gln Gly 
865                 870                 875                 880 


Val Ala Pro Ser Pro Cys Ile Pro Cys Cys Leu Val Leu Thr Asp Asp 
                885                 890                 895     


Arg Leu Phe Thr Cys His Glu Asp Cys Gln Thr Ser Phe Phe Arg Ser 
            900                 905                 910         


Leu Gly Thr Ala Lys Leu Gly Asp Ile Ser Ala Val Ser Thr Glu Pro 
        915                 920                 925             


Gly Lys Glu Tyr Cys Val Leu Glu Phe Ser Gln Asp Ser Gln Gln Leu 
    930                 935                 940                 


Leu Pro Pro Trp Val Ile Tyr Leu Ser Cys Thr Ser Glu Leu Asp Arg 
945                 950                 955                 960 


Leu Leu Ser Ala Leu Asn Ser Gly Trp Lys Thr Ile Tyr Gln Val Asp 
                965                 970                 975     


Leu Pro His Thr Ala Ile Gln Glu Ala Ser Asn Lys Lys Lys Phe Glu 
            980                 985                 990         


Asp Ala Leu Ser Leu Ile His Ser  Ala Trp Gln Arg Ser  Asp Ser Leu 
        995                 1000                 1005             


Cys Arg  Gly Arg Ala Ser Arg  Asp Pro Trp Cys 
    1010                 1015                 


<210>  5478
<211>  1304
<212>  DNA
<213>  Homosapiens

<400>  5478
ggcgacggtg gcagcgccat ggagccgggg gaggtgaagg accggatcct ggagaacatc     60

tcgctgtcgg tgaagaagtt gcagagctat tttgctgcat gtgaggatga gatccctgcc    120

atccggaacc atgacaaggt cctacagcgt ctgtgtgagc acctggacca cgccctgctg    180

tacggactgc aagacctctc ctctggctac tgggtgctcg tggtgcattt tactcggaga    240

gaggccatca agcagatcga ggtgctgcag cacgtggcca ccaacctggg gcgcagccgt    300

gcctggctgt acctggccct caacgagaac tccttggaga gctacctgcg gttgttccag    360

gagaacctgg gcctgctgca taagtactac gtcaagaatg ccctggtctg cagccacgat    420

cacctgacgc tcttcctgac cttggtgtcc gggctagagt tcattcgttt cgagctggat    480

ctggatgccc cttacctaga cctggccccc tacatgcccg actactacaa acctcagtac    540

ctgctggact ttgaagaccc ctgcagccag aagaaatgtg ccaagcaggg ggacggtgac    600

agccgcaacg gcagcccaag ccttgggcgg gactcgccag acactatgct tgcctccccc    660

caggaggagg gagaggggcc gagcagcacc acggagagca gcgagcgctc cgagccgggc    720

ctgctgatcc ctgagatgaa ggacacctcc atggagcgct tggggcagcc cctgagcaag    780

gttatcgacc agctcaacgg gcagctggac cccagcacct ggtgctcccg tgctgagccc    840

ccagaccagt cctttcggac cggctctccc ggggatgccc cggagaggcc gccgctttgc    900

gactttagtg aggggctttc agccccaatg gacttctacc gctttaccgt cgagagtcca    960

agcactgtta catcaggtgg cggccaccat gaccctgcag ggcttggcca accgctgcat   1020

gttcctagta gccctgaggc tgctggccaa gaagaagagg gaggaggagg agagggacag   1080

acgcctcggc ccctagagga taccacgagg gaggctcagg agctggaggc ccagctgtcc   1140

ctggtcaggg aggggcctgt gtctgagcca gagcctggga cccaggaggt tctctgccag   1200

ctcaagcgag accagcccag cccgtgtctg agtagcgctg aggattctgg ggtggatgag   1260

ggacagggga gcccttcgga gatggtccat tcctcggagt tcag                    1304


<210>  5479
<211>  427
<212>  PRT
<213>  Homosapiens

<400>  5479

Met Glu Pro Gly Glu Val Lys Asp Arg Ile Leu Glu Asn Ile Ser Leu 
1               5                   10                  15      


Ser Val Lys Lys Leu Gln Ser Tyr Phe Ala Ala Cys Glu Asp Glu Ile 
            20                  25                  30          


Pro Ala Ile Arg Asn His Asp Lys Val Leu Gln Arg Leu Cys Glu His 
        35                  40                  45              


Leu Asp His Ala Leu Leu Tyr Gly Leu Gln Asp Leu Ser Ser Gly Tyr 
    50                  55                  60                  


Trp Val Leu Val Val His Phe Thr Arg Arg Glu Ala Ile Lys Gln Ile 
65                  70                  75                  80  


Glu Val Leu Gln His Val Ala Thr Asn Leu Gly Arg Ser Arg Ala Trp 
                85                  90                  95      


Leu Tyr Leu Ala Leu Asn Glu Asn Ser Leu Glu Ser Tyr Leu Arg Leu 
            100                 105                 110         


Phe Gln Glu Asn Leu Gly Leu Leu His Lys Tyr Tyr Val Lys Asn Ala 
        115                 120                 125             


Leu Val Cys Ser His Asp His Leu Thr Leu Phe Leu Thr Leu Val Ser 
    130                 135                 140                 


Gly Leu Glu Phe Ile Arg Phe Glu Leu Asp Leu Asp Ala Pro Tyr Leu 
145                 150                 155                 160 


Asp Leu Ala Pro Tyr Met Pro Asp Tyr Tyr Lys Pro Gln Tyr Leu Leu 
                165                 170                 175     


Asp Phe Glu Asp Pro Cys Ser Gln Lys Lys Cys Ala Lys Gln Gly Asp 
            180                 185                 190         


Gly Asp Ser Arg Asn Gly Ser Pro Ser Leu Gly Arg Asp Ser Pro Asp 
        195                 200                 205             


Thr Met Leu Ala Ser Pro Gln Glu Glu Gly Glu Gly Pro Ser Ser Thr 
    210                 215                 220                 


Thr Glu Ser Ser Glu Arg Ser Glu Pro Gly Leu Leu Ile Pro Glu Met 
225                 230                 235                 240 


Lys Asp Thr Ser Met Glu Arg Leu Gly Gln Pro Leu Ser Lys Val Ile 
                245                 250                 255     


Asp Gln Leu Asn Gly Gln Leu Asp Pro Ser Thr Trp Cys Ser Arg Ala 
            260                 265                 270         


Glu Pro Pro Asp Gln Ser Phe Arg Thr Gly Ser Pro Gly Asp Ala Pro 
        275                 280                 285             


Glu Arg Pro Pro Leu Cys Asp Phe Ser Glu Gly Leu Ser Ala Pro Met 
    290                 295                 300                 


Asp Phe Tyr Arg Phe Thr Val Glu Ser Pro Ser Thr Val Thr Ser Gly 
305                 310                 315                 320 


Gly Gly His His Asp Pro Ala Gly Leu Gly Gln Pro Leu His Val Pro 
                325                 330                 335     


Ser Ser Pro Glu Ala Ala Gly Gln Glu Glu Glu Gly Gly Gly Gly Glu 
            340                 345                 350         


Gly Gln Thr Pro Arg Pro Leu Glu Asp Thr Thr Arg Glu Ala Gln Glu 
        355                 360                 365             


Leu Glu Ala Gln Leu Ser Leu Val Arg Glu Gly Pro Val Ser Glu Pro 
    370                 375                 380                 


Glu Pro Gly Thr Gln Glu Val Leu Cys Gln Leu Lys Arg Asp Gln Pro 
385                 390                 395                 400 


Ser Pro Cys Leu Ser Ser Ala Glu Asp Ser Gly Val Asp Glu Gly Gln 
                405                 410                 415     


Gly Ser Pro Ser Glu Met Val His Ser Ser Glu 
            420                 425         


<210>  5480
<211>  1344
<212>  DNA
<213>  Homosapiens

<400>  5480
gacaaggcag tttcagcctg gtgcttctgg ggttctgaaa agtgtcatca gctccatgaa     60

gagccttcag ccaccctctt caagttctca agtttctctc cccatcacac cctgtacaaa    120

tgggatgctg gcccacatag agccaaagag gctcccaggc acctcttgga ctgggctcaa    180

aatggatgca gctgccccgt cctaatcaaa tgaccttcct tgggccaggc gcagtggctc    240

acacctataa tcccagcact ttgggaggct caggtgatcc accccacctc atcctctcaa    300

agtgtgggat tacaggcatg aaccactgca cctggtccaa atccctgtta ttaaagagcc    360

tcctaccctc tgggccactt ccagcctgga acaggggagg tgagggaacc tggcctctga    420

acaggggagg tgagaactgc cacaccctga ggatgagggg cacgtggctc tccccgcatt    480

attagagacg tgattgctga gtaatgggtg acaggtgatc cgttcccaga taatgtgagt    540

atgaaatacc ttaactctgt gagaaataag atgtggcatt gggaaaaata aactatgaca    600

cttggccaag agtagcattg aagggtcccc tgtttgagtt aaattagctt ggattccaga    660

attccatcat aacatcatgt accctcttag cccctcttct tgcagcacac atgctggata    720

ttgttttttt ttccctccga ttctaacaac taacccccct cctgacacgc ctgctgcagt    780

cacttgacaa gcagggcctg accttcctct acagcctttc agagctccct gcggcctgag    840

aactaacagc ccagttgcac tgcttgcctc agggcagggt gagatttctg gagttcctgg    900

agcaggattc ctgagctcac tctggcagct cacccgggga ggctctgtct tctccttgga    960

cctggaggaa ggcaggactt ggggcagctc caaactctga gcctggggtg gccttcccct   1020

ggtctttggc ttatttacag agctggtggg catgcgggcc ttgacaccca ccacatctca   1080

tgatctgccc actcacctct cagggctcct cttgggtgca actgcgtgtg ctgaggagaa   1140

tcacaggagc cggagcaaga acacatgggc ttggcaggag cctgctttgg gaccgagaga   1200

cgcggttttc tgtatcttag aacttaggct ctgagatccc cggaaatctg gaaaaagtcc   1260

ccgatgttgc tggtcttttc tggcagagct actcattgcc tttagcctcc tcttttgtcc   1320

ttatattaaa agacagcaga ctta                                          1344


<210>  5481
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  5481

Met Gln Leu Pro Arg Pro Asn Gln Met Thr Phe Leu Gly Pro Gly Ala 
1               5                   10                  15      


Val Ala His Thr Tyr Asn Pro Ser Thr Leu Gly Gly Ser Gly Asp Pro 
            20                  25                  30          


Pro His Leu Ile Leu Ser Lys Cys Gly Ile Thr Gly Met Asn His Cys 
        35                  40                  45              


Thr Trp Ser Lys Ser Leu Leu Leu Lys Ser Leu Leu Pro Ser Gly Pro 
    50                  55                  60                  


Leu Pro Ala Trp Asn Arg Gly Gly Glu Gly Thr Trp Pro Leu Asn Arg 
65                  70                  75                  80  


Gly Gly Glu Asn Cys His Thr Leu Arg Met Arg Gly Thr Trp Leu Ser 
                85                  90                  95      


Pro His Tyr 
            


<210>  5482
<211>  1339
<212>  DNA
<213>  Homosapiens

<400>  5482
gtggagggtg gacgatggag acaagccact caccaggcct tgcagccccg cccccactca     60

aagctcacca agacgcagta ctccttgccc ggctcggtgg agacggcgct gatgtcgccc    120

agcttggctg tgcccaaaga gcggaagaag ctggtctggc aatcctcatg gcacgtaaag    180

aggcggtcat ccgtgaggac caggcagcag ggctcctgcc aagcccatgt gttcttgctc    240

cggctcctgt gattctcctc agcacacgca gttgcaccca agaggagccc tgagaggtcc    300

aaggagaaga cagagcctcc ccgggtgagc tgccagagtg agctcaggaa tcctgctcca    360

ggaactccag aaatctcacc ctgccctgag gcaagcagtg caactgggct gttagttctc    420

aggccgcagg gagctctgaa aggctgtaga ggaaggtcag gccctgcttg tcaagtgact    480

gcagcaggcg tgtcaggagg ggggttagtt gttagaatcg gagggaaaaa aaaacaatat    540

ccagcatgtg tgctgcaaga agaggggcta agagggtaca tgatgttatg atggaattct    600

ggaatccaag ctaatttaac tcaaacaggg gacccttcaa tgctactctt ggccaagtgt    660

catagtttat ttttcccaat gccacatctt atttctcaca gagttaaggt atttcatact    720

cacattatct gggaacggat cacctgtcac ccattactca gcaatcacgt ctctaataat    780

gcggggagag ccacgtgccc ctcatcctca gggtgtggca gttctcacct cccctgttca    840

gaggccaggt tccctcacct cccctgttcc aggctggaag tggcccagag ggtaggaggc    900

tctttaataa cagggatttg gaccaggtgc agtggttcat gcctgtaatc ccacactttg    960

agaggatgag gtggggtgga tcacctgagg tcaggagttt gagaccagcc tggccaacat   1020

ggtgaaaccc tgtctctact aaaaatacaa aaattagccg ggcgtggtgg cacacacctg   1080

taatcccagc tacttgggag gctgaggcag gagaattgct tgaacccggg aggtggaggt   1140

tacagtaagc caagatcaca ccactgcact ccagcctgag caacagagcg agactccgtc   1200

tcaaaaagta aaataaaata acataaagta aaataacagg gatctgctat ggcctcagat   1260

ttaaggggga aacattcacc ttattggcaa catagccttt gctttgagta atcgtggcaa   1320

cctgggaata gctttgtga                                                1339


<210>  5483
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  5483

Met Glu Thr Ser His Ser Pro Gly Leu Ala Ala Pro Pro Pro Leu Lys 
1               5                   10                  15      


Ala His Gln Asp Ala Val Leu Leu Ala Arg Leu Gly Gly Asp Gly Ala 
            20                  25                  30          


Asp Val Ala Gln Leu Gly Cys Ala Gln Arg Ala Glu Glu Ala Gly Leu 
        35                  40                  45              


Ala Ile Leu Met Ala Arg Lys Glu Ala Val Ile Arg Glu Asp Gln Ala 
    50                  55                  60                  


Ala Gly Leu Leu Pro Ser Pro Cys Val Leu Ala Pro Ala Pro Val Ile 
65                  70                  75                  80  


Leu Leu Ser Thr Arg Ser Cys Thr Gln Glu Glu Pro 
                85                  90          


<210>  5484
<211>  612
<212>  DNA
<213>  Homosapiens

<400>  5484
ggactgggcc ttgggtgact gagggtggcc tggcaggaga gagctgtctg ggggcagagg     60

ccaaggtggg catgttggta ccggccccag cctgagcaga cacacctgac agctggccca    120

ggtggcgttc tcttctcagc gggcacaaag ggcatcccag ggcaggcctg gcagcaagtc    180

cttaccagcc aaggtcactc ctcaagtcct actcacccag gtgccctgaa ggcctcccag    240

ctgcccgccc tgtgggcatt tgcacatatc ctgacaagcc tgaaagaagc tccgggtgcc    300

cattgttcag tccaggtgcc cattgttccc gggactgagg cccgggaaag ggaagcgacg    360

tggcagggcc agcagcagac cctgggcctt tctctagact gagcaccatt ccccgtgggt    420

gtgctctcag cgccgcaccg accttcacac tgcagagatg gatgccaact ccctggcagg    480

ggcaggactg ctgccgagca gccccacctg ccctcccagc cacaccccaa gtctgtaagg    540

gccgctccca ggaacacctg ctactgcaca ctccaaacca ataaagtttt atattttgtt    600

tacttcaacg ac                                                        612


<210>  5485
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5485

Met Pro Thr Pro Trp Gln Gly Gln Asp Cys Cys Arg Ala Ala Pro Pro 
1               5                   10                  15      


Ala Leu Pro Ala Thr Pro Gln Val Cys Lys Gly Arg Ser Gln Glu His 
            20                  25                  30          


Leu Leu Leu His Thr Pro Asn Gln 
        35                  40  


<210>  5486
<211>  3099
<212>  DNA
<213>  Homosapiens

<400>  5486
ggactgctga gatagaccag ggacaccagg cagccacagg cctgtcagac caggaccctt     60

accctctaga catggcctcg gtcccctgca aaccccagcc ccgtagccct gcgaggttac    120

agacagccta aacgccacca ccacagggcc tgtgccgtgc ccctgacccg ggcacagaag    180

gccactggcc cggaggccat ggagacggtg cccccagcag tggacctggt gctgggtgct    240

tctgcctgct gcctggcctg tgtcttcacc aaccccctgg aggtggtgaa gacgcggctg    300

cagctgcagg gggagctgca ggcccggggc acctacccac ggccctacca tggcttcata    360

gcctctgtcg ctgctgtggc ccgagcagac gggctgtggg gcctgcagaa ggggctggct    420

gccggccttc tgtaccaagg cctcatgaat ggcgttcgtt tctactgcta cagcctggcg    480

tgccaggctg gcctcacgca gcaaccaggt ggcaccgtgg ttgcgggagc cgtggcgggg    540

gcactgggag ccttcgtggg gagccctgct tacctgatca aaacgcagct gcaagctcag    600

acagtggccg cagtggccgt gggacaccag cacaatcacc agactgtcct gggtgccttg    660

gagaccatct ggcggcagca agggctcttg gggctgtggc agggcgttgg tggggctgtg    720

ccccgagtca tggtgggctc agctgcccag ctggccacct tcgcctctgc caaggcctgg    780

gtacagaagc aacagtggct ccctgaggac agctggctgg tggccctggc tgggggcatg    840

atcagcagca tagccgtggt tgtcgtcatg actcccttcg atgtggtcag cacgcggcta    900

tacaatcagc cggtggacac agctggcagg ggccagctct atgggggcct caccgactgc    960

atggtgaaga tctggcggca ggagggcccc ctggcactct acaagggcct gggccccgcc   1020

tacctgcgcc tgggccccca caccatcctc agcatgctct tctgggacga gcttcggaaa   1080

ctggctgggc gggcccagca caagggcacc tagacgacgg ccctcacccc cacgtcctga   1140

cacggccggc acttggccgg aagtgagagc ctgctccagg acaactggct gtcccggggc   1200

gggccatggg cccaggccct gccagaggtc ccgggagagt gtggacagct ctggtccatc   1260

cagccccttg gcccacccag gtccagagca tccacttcaa gttaccaccc attctgtctt   1320

ccagacagtt ctcttccttc tctgtactgc gtactgggtc accacatccc agagccttgc   1380

tcagttatag caactgctgc gggcgtgcac atggcatagg cccagtaact tacatacatc   1440

ggctcactta ggcctcagac agcagcacga ggcaggcact tttacttctt ttaccattag   1500

aaagccaagg cctagagtgg tgggctttga ccacagccac acaattttga agtggcagag   1560

ccaggactgg agcttagccc tgctcaccct agacctatgc gcttgacaag tgcgtgactg   1620

tgacaggccc atgggcccgg actgcccata ggggtcactg taccatggca aaggctgagg   1680

tgcaccagga ggctgtggcg tcgtcacctg ccttatttgc tggagaagct gtagcaaaga   1740

accacagact gggcgactta gacaatagaa atgtattttc tcacagttct ggaggctgga   1800

tgctggagac caaggtgtca gtgggctggt ttcttctgag gcctctgtcc atggcttgca   1860

gatgctgctt tctctctgtg tctgcacatg gtggtccctc gatgtgcgtc tgggtcctga   1920

tctcctcctc ttataaggac acaaatcatg ttggcttagg gcccaccctc atgaccccac   1980

tttaattttt tttttttttt ttgagatgaa gtctcactct gccacccaag ctggagtgca   2040

gtggcacgat ctcggttcac tgcaaccttg gcctcctagg ttcaagcaat tctcctgccc   2100

cagcctcctg agtagctggg attacaggtg tgtgccacca cacccggcca atttttgtat   2160

ctttagtaga gatggggttt tgccatgttg gccagactgg tctcgaactc ctgacctcaa   2220

gtgatccact ggccttggcc tcccaaagtg ctgggattac aggcatgagc cacctcactt   2280

ggcccaattt taacttaatt atctctgtca agagcctatc tccatataca gtcacatcct   2340

gagctactag ggggtaggac ttcaacatgc acttctgcag gggccgcagt tcagccaaca   2400

tcatcttttt ttttgagatg gagtctcgct ttgttgccca ggctggagtg cggtggtgca   2460

atctcggctc accacaacct ccacctccca ggttcaagtg attctcctgc ctcagcctcc   2520

cgagttgctg ggactatagg tgtgcgccac catgcccagc taattttgta tttttagtag   2580

agacaggctt tcgctgtgtt ggccaggctg gtcttgaatg cctgaccttg ccgcccgcct   2640

cggcctccca aaatgctggg attacaggcg tgagccaccg cgcctggcct cagccaacat   2700

catctaaggg ctctcacgga gggcctccca gctgcccgcc ctgtgggcat ttgcacatat   2760

cctgacaagc ctgaaagaag ctccgggtgc ccattgttca gtccaggtgc ccattgttcc   2820

cgggactgag gcccgggaaa gggaagcgac gtggcagggc cagcagcaga ccctgggcct   2880

ttctctagac tgagcaccat tccccgtggg tgtgctctca gcgccgcacc gaccttcaca   2940

ctgcagagat ggatgccaac tccctggcag gggcaggact gctgccgagc agccccacct   3000

gccctcccag ccacacccca agtctgtaag ggccgctccc aggaacacct gctactgcac   3060

actccaaacc aataaagttt tatattttgt ttacttcaa                          3099


<210>  5487
<211>  304
<212>  PRT
<213>  Homosapiens

<400>  5487

Met Glu Thr Val Pro Pro Ala Val Asp Leu Val Leu Gly Ala Ser Ala 
1               5                   10                  15      


Cys Cys Leu Ala Cys Val Phe Thr Asn Pro Leu Glu Val Val Lys Thr 
            20                  25                  30          


Arg Leu Gln Leu Gln Gly Glu Leu Gln Ala Arg Gly Thr Tyr Pro Arg 
        35                  40                  45              


Pro Tyr His Gly Phe Ile Ala Ser Val Ala Ala Val Ala Arg Ala Asp 
    50                  55                  60                  


Gly Leu Trp Gly Leu Gln Lys Gly Leu Ala Ala Gly Leu Leu Tyr Gln 
65                  70                  75                  80  


Gly Leu Met Asn Gly Val Arg Phe Tyr Cys Tyr Ser Leu Ala Cys Gln 
                85                  90                  95      


Ala Gly Leu Thr Gln Gln Pro Gly Gly Thr Val Val Ala Gly Ala Val 
            100                 105                 110         


Ala Gly Ala Leu Gly Ala Phe Val Gly Ser Pro Ala Tyr Leu Ile Lys 
        115                 120                 125             


Thr Gln Leu Gln Ala Gln Thr Val Ala Ala Val Ala Val Gly His Gln 
    130                 135                 140                 


His Asn His Gln Thr Val Leu Gly Ala Leu Glu Thr Ile Trp Arg Gln 
145                 150                 155                 160 


Gln Gly Leu Leu Gly Leu Trp Gln Gly Val Gly Gly Ala Val Pro Arg 
                165                 170                 175     


Val Met Val Gly Ser Ala Ala Gln Leu Ala Thr Phe Ala Ser Ala Lys 
            180                 185                 190         


Ala Trp Val Gln Lys Gln Gln Trp Leu Pro Glu Asp Ser Trp Leu Val 
        195                 200                 205             


Ala Leu Ala Gly Gly Met Ile Ser Ser Ile Ala Val Val Val Val Met 
    210                 215                 220                 


Thr Pro Phe Asp Val Val Ser Thr Arg Leu Tyr Asn Gln Pro Val Asp 
225                 230                 235                 240 


Thr Ala Gly Arg Gly Gln Leu Tyr Gly Gly Leu Thr Asp Cys Met Val 
                245                 250                 255     


Lys Ile Trp Arg Gln Glu Gly Pro Leu Ala Leu Tyr Lys Gly Leu Gly 
            260                 265                 270         


Pro Ala Tyr Leu Arg Leu Gly Pro His Thr Ile Leu Ser Met Leu Phe 
        275                 280                 285             


Trp Asp Glu Leu Arg Lys Leu Ala Gly Arg Ala Gln His Lys Gly Thr 
    290                 295                 300                 


<210>  5488
<211>  613
<212>  DNA
<213>  Homosapiens

<400>  5488
tatttcactt gacccctaag cttcaggctc gggaccatgg agctgtgagt ttcaggggca     60

cgggggcagg gcgccctcaa cacacacagc tcaccctggc tctcccaggc tccatcccca    120

cacccgtgtc ctctctgctc ccatagatca aaacgcagct gcaagctcag acagtggccg    180

cagtggccgt gggacaccag cacaatcacc agactgtcct gggtgccttg gagaccatct    240

ggcggcagca agggctcttg gggctgtggc agggcgttgg tggggctgtg ccccgagtca    300

tggtgggctc agctgcccag ctggccacct tcgcctctgc caaggcctgg gtacagaagc    360

aacagtggct ccctgaggac agctggctgg tggccctggc tgggggcatg atcagcagca    420

tagccgtggt tgtcgtcatg actcccttcg atgtggtcag cacgcggcta tacaatcagc    480

cggtggacac agctggcagg ggccagctct atgggggcct caccgactgc atggtgaaga    540

tctggcggca ggagggcccc ctggcactct acaagggcct gggccccgcc tacctgcgcc    600

tgggccccca cac                                                       613


<210>  5489
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  5489

Met Val Gly Ser Ala Ala Gln Leu Ala Thr Phe Ala Ser Ala Lys Ala 
1               5                   10                  15      


Trp Val Gln Lys Gln Gln Trp Leu Pro Glu Asp Ser Trp Leu Val Ala 
            20                  25                  30          


Leu Ala Gly Gly Met Ile Ser Ser Ile Ala Val Val Val Val Met Thr 
        35                  40                  45              


Pro Phe Asp Val Val Ser Thr Arg Leu Tyr Asn Gln Pro Val Asp Thr 
    50                  55                  60                  


Ala Gly Arg Gly Gln Leu Tyr Gly Gly Leu Thr Asp Cys Met Val Lys 
65                  70                  75                  80  


Ile Trp Arg Gln Glu Gly Pro Leu Ala Leu Tyr Lys Gly Leu Gly Pro 
                85                  90                  95      


Ala Tyr Leu Arg Leu Gly Pro 
            100             


<210>  5490
<211>  406
<212>  DNA
<213>  Homosapiens

<400>  5490
aggagccaga actggaattc aggcctgacc ccacagcctt cccatggcgc cgcagcctca     60

cagggccagc tctatggggg cctcaccgac tgcatggtga agatctggcg gcaggagggc    120

cccctggcac tctacaaggg cctgggcccc gcctacctgc gcctgggccc ccacaccatc    180

ctcagcatgc tcttctggga cgagcttcgg aaactggctg ggcgggccca gcacaagggc    240

acctagacga cggccctcac ccccacgtcc tgacacggcc ggcacttggc cggaagtgag    300

agcctgctcc aggacaactg gctgtcccgg ggcgggccat gggcccaggc cctgccagag    360

gtcccgggag agtgtggaca gctctggtcc atccagcccc ttggcc                   406


<210>  5491
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  5491

Met Val Lys Ile Trp Arg Gln Glu Gly Pro Leu Ala Leu Tyr Lys Gly 
1               5                   10                  15      


Leu Gly Pro Ala Tyr Leu Arg Leu Gly Pro His Thr Ile Leu Ser Met 
            20                  25                  30          


Leu Phe Trp Asp Glu Leu Arg Lys Leu Ala Gly Arg Ala Gln His Lys 
        35                  40                  45              


Gly Thr 
    50  


<210>  5492
<211>  1739
<212>  DNA
<213>  Homosapiens

<400>  5492
accgactgca tggtgaagat ctggcggcag gagggccccc tggcactcta caagggcctg     60

ggccccgcct acctgcgcct gggcccccac accatcctca gcatgctctt ctgggacgag    120

cttcggaaac tggctgggcg ggcccagcac aagggcacct agacgacggc cctcaccccc    180

acgtcctgac acggccggca cttggccgga agtgagagcc tgctccagga caactggctg    240

tcccggggcg ggccatgggc ccaggccctg ccagaggtcc cgggagagtg tggacagctc    300

tggtccatcc agccccttgg cccacccagg tccagagcat ccacttcaag ttaccaccca    360

ttctgtcttc cagacagttc tcttccttct ctgtactgcg tactgggtca ccacatccca    420

gagccttgct cagttatagc aactgctgcg ggcgtgcaca tggcataggc ccagtaactt    480

acatacatcg gctcacttag gcctcagaca gcagcacgag gcaggcactt ttacttcttt    540

taccattaga aagccaaggc ctagagtggt gggctttgac cacagccaca caattttgaa    600

gtggcagagc caggactgga gcttagccct gctcacccta gacctatgcg cttgacaagt    660

gcgtgactgt gacaggccca tgggcccgga ctgcccatag gggtcactgt accatggcaa    720

aggctgaggt gcaccaggag gctgtggcgt cgtcacctgc cttatttgct ggagaagctg    780

tagcaaagaa ccacagactg ggcgacttag acaatagaaa tgtattttct cacagttctg    840

gaggctggat gctggagacc aaggtgtcag tgggctggtt tcttctgagg cctctgtcca    900

tggcttgcag atgctgcttt ctctctgtgt ctgcacatgg tggtccctcg atgtgcgtct    960

gggtcctgat ctcctcctct tataaggaca caaatcatgt tggcttaggg cccaccctca   1020

tgaccccact ttaattttta tcatcttttt ttttgagatg gagtctcgct ttgttgccca   1080

ggctggagtg cggtggtgca atctcggctc accacaacct ccacctccca ggttcaagtg   1140

attctcctgc ctcagcctcc cgagttgctg ggactatagg tgtgcgccac catgcccagc   1200

taattttgta tttttagtag agacaggctt tcgctgtgtt ggccaggctg gtcttgaatg   1260

cctgaccttg ccgcccgcct cggcctccca aaatgctggg attacaggcg tgagccaccg   1320

cgcctggcct cagccaacat catctaaggg ctctcacgga gggcctccca gctgcccgcc   1380

ctgtgggcat ttgcacatat cctgacaagc ctgaaagaag ctccgggtgc ccattgttca   1440

gtccaggtgc ccattgttcc cgggactgag gcccgggaaa gggaagcgac gtggcagggc   1500

cagcagcaga ccctgggcct ttctctagac tgagcaccat tccccgtggg tgtgctctca   1560

gcgccgcacc gaccttcaca ctgcagagat ggatgccaac tccctggcag gggcaggact   1620

gctgccgagc agccccacct gccctcccag ccacacccca agtctgtaag ggccgctccc   1680

aggaacacct gctactgcac actccaaacc aataaagttt tatattttgt ttacttcaa    1739


<210>  5493
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  5493

Met Ala Lys Ala Glu Val His Gln Glu Ala Val Ala Ser Ser Pro Ala 
1               5                   10                  15      


Leu Phe Ala Gly Glu Ala Val Ala Lys Asn His Arg Leu Gly Asp Leu 
            20                  25                  30          


Asp Asn Arg Asn Val Phe Ser His Ser Ser Gly Gly Trp Met Leu Glu 
        35                  40                  45              


Thr Lys Val Ser Val Gly Trp Phe Leu Leu Arg Pro Leu Ser Met Ala 
    50                  55                  60                  


Cys Arg Cys Cys Phe Leu Ser Val Ser Ala His Gly Gly Pro Ser Met 
65                  70                  75                  80  


Cys Val Trp Val Leu Ile Ser Ser Ser Tyr Lys Asp Thr Asn His Val 
                85                  90                  95      


Gly Leu Gly Pro Thr Leu Met Thr Pro Leu 
            100                 105     


<210>  5494
<211>  631
<212>  DNA
<213>  Homosapiens

<400>  5494
ggctgtgcca gggatccaga ggctaaagca cattccagca aaaacactgg cccccgcttg     60

gaacccagag cccagtctgg gtccggcaag gggctggccc tgtgcccacc taactgagcc    120

atttccttcc agactggggc acatttcctg cccggaggga acagagcaca ttcccaggcg    180

gcatggactg ggtcctgcat tgggggaggg gattccgtag gcattttccc aaccccagcg    240

accacgccct gggatgagag gcctgtcctg gtggtagggc taggagcacg gttcaaaggg    300

tgctgctgga gctgtccaag gggtggccat tcttcgggga atgagctgaa accacccggc    360

cctgccttgg gtgcagcctg ctctgtatcc caggtgtgct gagcgtagag cgagaaggat    420

ccttgagtca cccctgcctg ctcccaagca gcagtcttcg gaggaggaga tcaggaccca    480

gacgcacatc gagggaccac catgtgcaga cacagagaga aagcagcatc tgcaagccat    540

ggacagaggc ctcagaagaa accagcccac tgacaccttg gtctccagca tccagcctcc    600

agaactgtga gaaaatacat ttctattgtc t                                   631


<210>  5495
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  5495

Ala Glu Thr Thr Arg Pro Cys Leu Gly Cys Ser Leu Leu Cys Ile Pro 
1               5                   10                  15      


Gly Val Leu Ser Val Glu Arg Glu Gly Ser Leu Ser His Pro Cys Leu 
            20                  25                  30          


Leu Pro Ser Ser Ser Leu Arg Arg Arg Arg Ser Gly Pro Arg Arg Thr 
        35                  40                  45              


Ser Arg Asp His His Val Gln Thr Gln Arg Glu Ser Ser Ile Cys Lys 
    50                  55                  60                  


Pro Trp Thr Glu Ala Ser Glu Glu Thr Ser Pro Leu Thr Pro Trp Ser 
65                  70                  75                  80  


Pro Ala Ser Ser Leu Gln Asn Cys Glu Lys Ile His Phe Tyr 
                85                  90                  


<210>  5496
<211>  1112
<212>  DNA
<213>  Homosapiens

<400>  5496
tttttgtatt tttagtagag acagagtttt accatattgg tcaggctggt ctcgaactcc     60

tgaccttgtg atctgcccac cttggcctcc caaagtgctg ggattacaag tgtaagccac    120

tgcgcctgtc ctccctcaag gaagatttca agtaaagtgg atgccagact ttagcaggga    180

cagagaccag agaccagccc agagacacct gtcccttcac cccacactgc ccaaatgggg    240

agcccgggca gcagctggct ccaggcaccc cgtgtgcctg gagctgggac cttgcccttc    300

tgggcctcga agggttaaca cccctggctc tcctcccctc ccctcccctg ggcctttgac    360

ccctcccagc ctctctcctt ccctccaccg acacctttgc ccagtgacgt tggtctgtcc    420

ttacgcagac ctggccggag gctggggctc cttccggggc tgccatgttc tctcttccat    480

ccctcccctc ctggctcccc ggcctcccct ccctcgagtg gggctctagc ctccttgact    540

ccctcctgca aggcctgatc ggggcccttg gagtcttggt cctgaacagc ctcctgaaag    600

tttacttctt cgtgggctgt gccaatgacc cgcagcggcg acccgaaaag gagcggcttc    660

gggcccagtg ggcctccctg gaaacggtgc acctggcagg gctggccctg tttctgacgg    720

tcgtggggtc ccgggtggct gccctcgtgg tgctcgagtt ctccctccgg gccgtgtcca    780

cgctgctgtc cctgggcaag ggctcccagg gtgccgccga gaggctgcag ctctacctgc    840

tgtgccagta ctcgctgggc tgcgggctga cctgtggcct gagcttcctg caggagggcg    900

cccctcaccg cacgctgaac ctgctgctga gcctcgggct ggccacgctg ctgggcctgg    960

gtgcccggcg cctccaccgc cacgtctgcc gcctctacga gctgcacagc agccagcgct   1020

actgtggggt gtgcctgggc ctgctggccc atgcacatgg cctcccccag ctgctgggcc   1080

gtgccctggc catagccttt gccgtgggtg ac                                 1112


<210>  5497
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  5497

Met Phe Ser Leu Pro Ser Leu Pro Ser Trp Leu Pro Gly Leu Pro Ser 
1               5                   10                  15      


Leu Glu Trp Gly Ser Ser Leu Leu Asp Ser Leu Leu Gln Gly Leu Ile 
            20                  25                  30          


Gly Ala Leu Gly Val Leu Val Leu Asn Ser Leu Leu Lys Val Tyr Phe 
        35                  40                  45              


Phe Val Gly Cys Ala Asn Asp Pro Gln Arg Arg Pro Glu Lys Glu Arg 
    50                  55                  60                  


Leu Arg Ala Gln Trp Ala Ser Leu Glu Thr Val His Leu Ala Gly Leu 
65                  70                  75                  80  


Ala Leu Phe Leu Thr Val Val Gly Ser Arg Val Ala Ala Leu Val Val 
                85                  90                  95      


Leu Glu Phe Ser Leu Arg Ala Val Ser Thr Leu Leu Ser Leu Gly Lys 
            100                 105                 110         


Gly Ser Gln Gly Ala Ala Glu Arg Leu Gln Leu Tyr Leu Leu Cys Gln 
        115                 120                 125             


Tyr Ser Leu Gly Cys Gly Leu Thr Cys Gly Leu Ser Phe Leu Gln Glu 
    130                 135                 140                 


Gly Ala Pro His Arg Thr Leu Asn Leu Leu Leu Ser Leu Gly Leu Ala 
145                 150                 155                 160 


Thr Leu Leu Gly Leu Gly Ala Arg Arg Leu His Arg His Val Cys Arg 
                165                 170                 175     


Leu Tyr Glu Leu His Ser Ser Gln Arg Tyr Cys Gly Val Cys Leu Gly 
            180                 185                 190         


Leu Leu Ala His Ala His Gly Leu Pro Gln Leu Leu Gly Arg Ala Leu 
        195                 200                 205             


Ala Ile Ala Phe Ala Val Gly 
    210                 215 


<210>  5498
<211>  663
<212>  DNA
<213>  Homosapiens

<400>  5498
cgccgagagg ctgcagctct acctgctgtg ccagtactcg ctgggctgcg ggctgacctg     60

tggcctgagc ttcctgcagg agggcgcccc tcaccgcacg ctgaacctgc tgctgagcct    120

cgggctggcc acgctgctgg gcctgggtgc ccggcgcctc caccgccacg tctgccgcct    180

ctacgagctg cacagcagcc agcgctactg tggggtgtgc ctgggcctgc tggcccatgc    240

acatggcctc ccccagctgc tgggccgtgc cctggccata gcctttgccg tgggtgacct    300

ggcagctgtg gccctcatca accaggactt cctgaccacc tcggaggcca tgcggttctg    360

gacaccgctc accatctgct acacgctgct ggtcatctac atgcaggagg agcagcggca    420

gcaccccggc ctgcagagcc aggtgcagac ggtgctggtg cgcatgggcg gcctcttcgt    480

gctgctgctg actgtgggtc gctggctgga cctgctgggc atccttgtct ccctactggg    540

cgagctctgg tgtctcgtgg gcgtccgcac cctgcttgac ctctgccaga tacaggattt    600

tccatcccag aggcctccag tgtcaacacc aagccagccc ctgccctcgg caccccagtc    660

cca                                                                  663


<210>  5499
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  5499

Met Arg Phe Trp Thr Pro Leu Thr Ile Cys Tyr Thr Leu Leu Val Ile 
1               5                   10                  15      


Tyr Met Gln Glu Glu Gln Arg Gln His Pro Gly Leu Gln Ser Gln Val 
            20                  25                  30          


Gln Thr Val Leu Val Arg Met Gly Gly Leu Phe Val Leu Leu Leu Thr 
        35                  40                  45              


Val Gly Arg Trp Leu Asp Leu Leu Gly Ile Leu Val Ser Leu Leu Gly 
    50                  55                  60                  


Glu Leu Trp Cys Leu Val Gly Val Arg Thr Leu Leu Asp Leu Cys Gln 
65                  70                  75                  80  


Ile Gln Asp Phe Pro Ser Gln Arg Pro Pro Val Ser Thr Pro Ser Gln 
                85                  90                  95      


Pro Leu Pro Ser Ala Pro Gln 
            100             


<210>  5500
<211>  2314
<212>  DNA
<213>  Homosapiens

<400>  5500
gttgcaggaa gtttggcacc tgccgatcgg tgacatcgac acccgagctg ctgcgggcca     60

ggacgaatcc ctccatccgg gagcagtggt ggcggtggaa caggtggcct ggggtgctgg    120

aggcaggcca acctggagag gtaggcagtg gctacctcca ctttacagat gaagacactg    180

aggctcagga ggtggcgtga ctgctccggg tctcacgctt agtaaacggc cgcagaaccc    240

tggtcggttt gacgcaagac cctggcggat cccagagcca aacagagctg gcctgaacct    300

ccaggacttc agcccttcta ggagaatctg atcccaggtg agggaggtca cttggggtgt    360

ggcccagcag gcaggcggga ctccagactg ggaacggaag tcagccctgc tggggctggg    420

agctgaagca tctgttcctt cctcgcgggt gtgagacaag gaagagtgat cattgccaca    480

ccaggagctg aagccatggc ctcaaagcct gagaagaggg tggcatcgtc tgtctttatc    540

accctggcac ccccgcgccg cgatgtggcc gtggcggagg aagtgaggca ggcagtttgt    600

gaggcccggc gtggccgccc ctgggaggct cctgccccca tgaagacacc cgaggctggc    660

ttggcgggga ggcccagccc ctggacaacc cctggcagag ctgcagccac agtgccggct    720

gcacctatgc agctcttcaa tggaggatgc ccaccccctc ctcctgtcct ggatggtgag    780

gacgtgcttc ctgacctgga cctcctccca ccccctccac cgccccctcc agtgcttctg    840

ccttctgaag aggaggctcc tgctccaatg ggggcctcac tcattgcaga cttagagcag    900

ctgcacctgt ccccgccccc gcccccacca caggccccag cggagggacc ttcagtccag    960

cccggtcccc tcaggcccat ggaggaagag ctgccacctc ccccggcaga acctgttgag   1020

aaaggggcat ccacagacat ctgtgccttc tgccacaaga ccgtgtcccc ccgagagctg   1080

gctgtggagg ccatgaagag gcagtaccat gcccagtgct tcacgtgccg cacctgccgc   1140

cgccagctgg ctgggcagag cttctaccag aaggatgggc gacccctctg cgaaccctgc   1200

taccaggaca cactggagag gtgcggcaag tgtggcgagg tggtccggga ccacatcatc   1260

agggccctgg gccaggcctt ccacccctcc tgcttcacgt gtgtgacctg cgcccggtgc   1320

attggggatg agagctttgc cctgggcagc cagaacgagg tgtactgcct ggacgacttc   1380

tacaggaaat tcgcccccgt ctgcagcatc tgtgaaaatc ccatcatccc tcgggatggg   1440

aaagatgcct tcaaaatcga atgcatggga agaaacttcc atgaaaattg ctacaggtgt   1500

gaggactgca ggatcctcct gtctgtcgag cccacggacc aaggctgcta ccccctgaac   1560

aaccatctct tctgcaagcc atgccatgtg aagcggagtg ctgcggggtg ctgctgagag   1620

tgcccgctgg gcagtgaaca gaccactagc cccggctggg gcccttccct gacttggttt   1680

cccttcctaa cctgctcttg cacactttcc ttctgagcct ccatggagac cagcctgcaa   1740

gccggcccag cctgtccagg atacagtggg gctgagcacc cccaggcctt ccactcctct   1800

accctctggg caccagaagg ctcctggacc atgagcttca cccccagaat tccctgctga   1860

ccctgcccca cttccaggga aaagctgggg gaggttggac ccctctcact gactagctgt   1920

ctggtagggg tgctaggacc agcctcgcct gtggggttga gctgtttgag gacaaactcc   1980

aaggtccctt aaaaagtgcc ttttagaggc tgggcatggt ggctcacgct tgtaatccca   2040

gcactttggg aggccaaggt gggtggatca cctgaggtca ggagttcaag accagcctgg   2100

ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa ttagccaggc atggtagcag   2160

gtgcctgtaa tcccagctac tggggaaagc tgaggcagga gaattgcttc aatctggaag   2220

gcagaggttg cagtgagatt gcaccattgc attccagcct gggcaacaag agggaaactc   2280

cgtctcaaaa aaaaaaaagt gccttttagg ccgg                               2314


<210>  5501
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  5501

Met Ala Ser Lys Pro Glu Lys Arg Val Ala Ser Ser Val Phe Ile Thr 
1               5                   10                  15      


Leu Ala Pro Pro Arg Arg Asp Val Ala Val Ala Glu Glu Val Arg Gln 
            20                  25                  30          


Ala Val Cys Glu Ala Arg Arg Gly Arg Pro Trp Glu Ala Pro Ala Pro 
        35                  40                  45              


Met Lys Thr Pro Glu Ala Gly Leu Ala Gly Arg Pro Ser Pro Trp Thr 
    50                  55                  60                  


Thr Pro Gly Arg Ala Ala Ala Thr Val Pro Ala Ala Pro Met Gln Leu 
65                  70                  75                  80  


Phe Asn Gly Gly Cys Pro Pro Pro Pro Pro Val Leu Asp Gly Glu Asp 
                85                  90                  95      


Val Leu Pro Asp Leu Asp Leu Leu Pro Pro Pro Pro Pro Pro Pro Pro 
            100                 105                 110         


Val Leu Leu Pro Ser Glu Glu Glu Ala Pro Ala Pro Met Gly Ala Ser 
        115                 120                 125             


Leu Ile Ala Asp Leu Glu Gln Leu His Leu Ser Pro Pro Pro Pro Pro 
    130                 135                 140                 


Pro Gln Ala Pro Ala Glu Gly Pro Ser Val Gln Pro Gly Pro Leu Arg 
145                 150                 155                 160 


Pro Met Glu Glu Glu Leu Pro Pro Pro Pro Ala Glu Pro Val Glu Lys 
                165                 170                 175     


Gly Ala Ser Thr Asp Ile Cys Ala Phe Cys His Lys Thr Val Ser Pro 
            180                 185                 190         


Arg Glu Leu Ala Val Glu Ala Met Lys Arg Gln Tyr His Ala Gln Cys 
        195                 200                 205             


Phe Thr Cys Arg Thr Cys Arg Arg Gln Leu Ala Gly Gln Ser Phe Tyr 
    210                 215                 220                 


Gln Lys Asp Gly Arg Pro Leu Cys Glu Pro Cys Tyr Gln Asp Thr Leu 
225                 230                 235                 240 


Glu Arg Cys Gly Lys Cys Gly Glu Val Val Arg Asp His Ile Ile Arg 
                245                 250                 255     


Ala Leu Gly Gln Ala Phe His Pro Ser Cys Phe Thr Cys Val Thr Cys 
            260                 265                 270         


Ala Arg Cys Ile Gly Asp Glu Ser Phe Ala Leu Gly Ser Gln Asn Glu 
        275                 280                 285             


Val Tyr Cys Leu Asp Asp Phe Tyr Arg Lys Phe Ala Pro Val Cys Ser 
    290                 295                 300                 


Ile Cys Glu Asn Pro Ile Ile Pro Arg Asp Gly Lys Asp Ala Phe Lys 
305                 310                 315                 320 


Ile Glu Cys Met Gly Arg Asn Phe His Glu Asn Cys Tyr Arg Cys Glu 
                325                 330                 335     


Asp Cys Arg Ile Leu Leu Ser Val Glu Pro Thr Asp Gln Gly Cys Tyr 
            340                 345                 350         


Pro Leu Asn Asn His Leu Phe Cys Lys Pro Cys His Val Lys Arg Ser 
        355                 360                 365             


Ala Ala Gly Cys Cys 
    370             


<210>  5502
<211>  2431
<212>  DNA
<213>  Homosapiens

<400>  5502
atgaagaacg cgaggggatg ggcagcgggg agggaaggaa acccaccccg actccccatt     60

ctcctacccc cactccccat ccctcccatt cccccatcgc ccccatcccc attccccccc    120

attcccaccc cctggcctgt gccaaggggg aggggaggcg tcgtccaggg aacaaaggga    180

gggggaaggg gcggcgcggg gcgcggccgg gcaggttggg gggcaggtag gggccgcttc    240

cgcggggcgg gaatcccgcg ccccctcccc ccgagcctca ccttttatgg taaagcggcg    300

cggggcggcg gggcggaggg agccgagggg gcggggaggg cggacgggcg gaggggacgg    360

gaggcccagc ggctccgggc tccgctggct cgggcgtcgg atcggagccg ccggggcgcg    420

ggcggcccag agctggcctg aacctccagg acttcagccc ttctaggaga atctgatccc    480

aggtgaggga ggtcacttgg ggtgtggccc agcaggcagg cgggactcca gactgggaac    540

ggaagtcagc cctgctgggg ctgggagctg aagcatctgt tccttcctcg cgggtgtgag    600

acaaggaaga gtgatcattg ccacaccagg agctgaagcc atggcctcaa agcctgagaa    660

gagggtggca tcgtctgtct ttatcaccct ggcacccccg cgccgcgatg tggccgtggc    720

ggaggaagtg aggcaggcag tttgtgaggc ccggcgtggc cgcccctggg aggctcctgc    780

ccccatgaag acacccgagg ctggcttggc ggggaggccc agcccctgga caacccctgg    840

cagagctgca gccacagtgc cggctgcacc tatgcagctc ttcaatggag gatgcccacc    900

ccctcctcct gtcctggatg gtgaggacgt gcttcctgac ctggacctcc tcccaccccc    960

tccaccgccc cctccagtgc ttctgccttc tgaagaggag gctcctgctc caatgggggc   1020

ctcactcatt gcagacttag agcagctgca cctgtccccg cccccgcccc caccacaggc   1080

cccagcggag ggaccttcag tccagcccgg tcccctcagg cccatggagg aagagctgcc   1140

acctcccccg gcagaacctg ttgagaaagg ggcatccaca gacatctgtg ccttctgcca   1200

caagaccgtg tccccccgag agctggctgt ggaggccatg aagaggcagt accatgccca   1260

gtgcttcacg tgccgcacct gccgccgcca gctggctggg cagagcttct accagaagga   1320

tgggcgaccc ctctgcgaac cctgctacca ggacacactg gagaggtgcg gcaagtgtgg   1380

cgaggtggtc cgggaccaca tcatcagggc cctgggccag gccttccacc cctcctgctt   1440

cacgtgtgtg acctgcgccc ggtgcattgg ggatgagagc tttgccctgg gcagccagaa   1500

cgaggtgtac tgcctggacg acttctacag gaaattcgcc cccgtctgca gcatctgtga   1560

aaatcccatc atccctcggg atgggaaaga tgccttcaaa atcgaatgca tgggaagaaa   1620

cttccatgaa aattgctaca ggtgtgagga ctgcaggatc ctcctgtctg tcgagcccac   1680

ggaccaaggc tgctaccccc tgaacaacca tctcttctgc aagccatgcc atgtgaagcg   1740

gagtgctgcg gggtgctgct gagagtgccc gctgggcagt gaacagacca ctagccccgg   1800

ctggggccct tccctgactt ggtttccctt cctaacctgc tcttgcacac tttccttctg   1860

agcctccatg gagaccagcc tgcaagccgg cccagcctgt ccaggataca gtggggctga   1920

gcacccccag gccttccact cctctaccct ctgggcacca gaaggctcct ggaccatgag   1980

cttcaccccc agaattccct gctgaccctg ccccacttcc agggaaaagc tgggggaggt   2040

tggacccctc tcactgacta gctgtctggt aggggtgcta ggaccagcct cgcctgtggg   2100

gttgagctgt ttgaggacaa actccaaggt cccttaaaaa gtgcctttta gaggctgggc   2160

atggtggctc acgcttgtaa tcccagcact ttgggaggcc aaggtgggtg gatcacctga   2220

ggtcaggagt tcaagaccag cctggccaac atggtgaaac cctgtctcta ctaaaaatac   2280

aaaaattagc caggcatggt agcaggtgcc tgtaatccca gctactgggg aaagctgagg   2340

caggagaatt gcttcaatct ggaaggcaga ggttgcagtg agattgcacc attgcattcc   2400

agcctgggca acaagaggga aactccgtct c                                  2431


<210>  5503
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  5503

Met Ala Ser Lys Pro Glu Lys Arg Val Ala Ser Ser Val Phe Ile Thr 
1               5                   10                  15      


Leu Ala Pro Pro Arg Arg Asp Val Ala Val Ala Glu Glu Val Arg Gln 
            20                  25                  30          


Ala Val Cys Glu Ala Arg Arg Gly Arg Pro Trp Glu Ala Pro Ala Pro 
        35                  40                  45              


Met Lys Thr Pro Glu Ala Gly Leu Ala Gly Arg Pro Ser Pro Trp Thr 
    50                  55                  60                  


Thr Pro Gly Arg Ala Ala Ala Thr Val Pro Ala Ala Pro Met Gln Leu 
65                  70                  75                  80  


Phe Asn Gly Gly Cys Pro Pro Pro Pro Pro Val Leu Asp Gly Glu Asp 
                85                  90                  95      


Val Leu Pro Asp Leu Asp Leu Leu Pro Pro Pro Pro Pro Pro Pro Pro 
            100                 105                 110         


Val Leu Leu Pro Ser Glu Glu Glu Ala Pro Ala Pro Met Gly Ala Ser 
        115                 120                 125             


Leu Ile Ala Asp Leu Glu Gln Leu His Leu Ser Pro Pro Pro Pro Pro 
    130                 135                 140                 


Pro Gln Ala Pro Ala Glu Gly Pro Ser Val Gln Pro Gly Pro Leu Arg 
145                 150                 155                 160 


Pro Met Glu Glu Glu Leu Pro Pro Pro Pro Ala Glu Pro Val Glu Lys 
                165                 170                 175     


Gly Ala Ser Thr Asp Ile Cys Ala Phe Cys His Lys Thr Val Ser Pro 
            180                 185                 190         


Arg Glu Leu Ala Val Glu Ala Met Lys Arg Gln Tyr His Ala Gln Cys 
        195                 200                 205             


Phe Thr Cys Arg Thr Cys Arg Arg Gln Leu Ala Gly Gln Ser Phe Tyr 
    210                 215                 220                 


Gln Lys Asp Gly Arg Pro Leu Cys Glu Pro Cys Tyr Gln Asp Thr Leu 
225                 230                 235                 240 


Glu Arg Cys Gly Lys Cys Gly Glu Val Val Arg Asp His Ile Ile Arg 
                245                 250                 255     


Ala Leu Gly Gln Ala Phe His Pro Ser Cys Phe Thr Cys Val Thr Cys 
            260                 265                 270         


Ala Arg Cys Ile Gly Asp Glu Ser Phe Ala Leu Gly Ser Gln Asn Glu 
        275                 280                 285             


Val Tyr Cys Leu Asp Asp Phe Tyr Arg Lys Phe Ala Pro Val Cys Ser 
    290                 295                 300                 


Ile Cys Glu Asn Pro Ile Ile Pro Arg Asp Gly Lys Asp Ala Phe Lys 
305                 310                 315                 320 


Ile Glu Cys Met Gly Arg Asn Phe His Glu Asn Cys Tyr Arg Cys Glu 
                325                 330                 335     


Asp Cys Arg Ile Leu Leu Ser Val Glu Pro Thr Asp Gln Gly Cys Tyr 
            340                 345                 350         


Pro Leu Asn Asn His Leu Phe Cys Lys Pro Cys His Val Lys Arg Ser 
        355                 360                 365             


Ala Ala Gly Cys Cys 
    370             


<210>  5504
<211>  3694
<212>  DNA
<213>  Homosapiens

<400>  5504
atgaagaacg cgaggggatg ggcagcgggg agggaaggaa acccaccccg actccccatt     60

ctcctacccc cactccccat ccctcccatt cccccatcgc ccccatcccc attccccccc    120

attcccaccc cctggcctgt gccaaggggg aggggaggcg tcgtccaggg aacaaaggga    180

gggggaaggg gcggcgcggg gcgcggccgg gcaggttggg gggcaggtag gggccgcttc    240

cgcggggcgg gaatcccgcg ccccctcccc ccgagcctca ccttttatgg taaagcggcg    300

cggggcggcg gggcggaggg agccgagggg gcggggaggg cggacgggcg gaggggacgg    360

gaggcccagc ggctccgggc tccgctggct cgggcgtcgg atcggagccg ccggggcgcg    420

ggcggcccag agctggcctg aacctccagg acttcagccc ttctaggaga atctgatccc    480

aggtgaggga ggtcacttgg ggtgtggccc agcaggcagg cgggactcca gactgggaac    540

ggaagtcagc cctgctgggg ctgggagctg aagcatctgt tccttcctcg cgggtgtgag    600

acaaggaaga gtgatcattg ccacaccagg agctgaagcc atggcctcaa agcctgagaa    660

gagggtggca tcgtctgtct ttatcaccct ggcacccccg cgccgcgatg tggccgtggc    720

ggaggaagtg aggcaggcag tttgtgaggc ccggcgtggc cgcccctggg aggctcctgc    780

ccccatgaag acacccgagg ctggcttggc ggggaggccc agcccctgga caacccctgg    840

cagagctgca gccacagtgc cggctgcacc tatgcagctc ttcaatggag gatgcccacc    900

ccctcctcct gtcctggatg gtgaggacgt gcttcctgac ctggacctcc tcccaccccc    960

tccaccgccc cctccagtgc ttctgccttc tgaagaggag gctcctgctc caatgggggc   1020

ctcactcatt gcagacttag agcagctgca cctgtccccg cccccgcccc caccacaggc   1080

cccagcggag ggaccttcag tccagcccgg tcccctcagg cccatggagg aagagctgcc   1140

acctcccccg gcagaacctg ttgagaaagg ggcatccaca gacatctgtg ccttctgcca   1200

caagaccgtg tccccccgag agctggctgt ggaggccatg aagaggcagt accatgccca   1260

gtgcttcacg tgccgcacct gccgccgcca gctggctggg cagagcttct accagaagga   1320

tgggcgaccc ctctgcgaac cctgctacca ggacacactg gagaggtgcg gcaagtgtgg   1380

cgaggtggtc cgggaccaca tcatcagggc cctgggccag gccttccacc cctcctgctt   1440

cacgtgtgtg acctgcgccc ggtgcattgg ggatgagagc tttgccctgg gcagccagaa   1500

cgaggtgtac tgcctggacg acttctacag gaaattcgcc cccgtctgca gcatctgtga   1560

aaatcccatc atccctcggg atgggaaaga tgccttcaaa atcgaatgca tgggaagaaa   1620

cttccatgaa aattgctaca ggtgtgagga ctgcaggatc ctcctgtctg tcgagcccac   1680

ggaccaaggc tgctaccccc tgaacaacca tctcttctgc aagccatgcc atgtgaagcg   1740

gagtgctgcg gggtgctgct gagagtgccc gctgggcagt gaacagacca ctagccccgg   1800

ctggggccct tccctgactt ggtttccctt cctaacctgc tcttgcacac tttccttctg   1860

agcctccatg gagaccagcc tgcaagccgg cccagcctgt ccaggataca gtggggctga   1920

gcacccccag gccttccact cctctaccct ctgggcacca gaaggctcct ggaccatgag   1980

cttcaccccc agaattccct gctgaccctg ccccacttcc agggaaaagc tgggggaggt   2040

tggacccctc tcactgacta gctgtctggt aggggtgcta ggaccagcct cgcctgtggg   2100

gttgagctgt ttgaggacaa actccaaggt cccttaaaaa gtgcctttta gaggctgggc   2160

atggtggctc acgcttgtaa tcccagcact ttgggaggcc aaggtgggtg gatcacctga   2220

ggtcaggagt tcaagaccag cctggccaac atggtgaaac cctgtctcta ctaaaaatac   2280

aaaaattagc caggcatggt agcaggtgcc tgtaatccca gctactgggg aaagctgagg   2340

caggagaatt gcttcaatct ggaaggcaga ggttgcagtg agattgcacc attgcattcc   2400

agcctgggca acaagaggga aactccgtct caaaaaaaaa aaagtgcctt ttaggccgga   2460

tgtggtggct catgcctgta atcccagcac tttgggaggc caaggcaggc agatcacttg   2520

aggtcaggag tttgagacca gcctggccaa cacggcaaaa ccccgtttct actaaaaata   2580

caaaaattag ctgggtgtgg tggcgtgcgc ctgtaatccc agctactcag gaggctgagg   2640

caggagcatt gcttgaaccc gggaggcaga ggttgcagtg agctgagatg gcaccactgc   2700

actccagcct gggagacaca gcgagactct gtctccaaaa aaaaaagtgc tttttgaaaa   2760

tgttgaggtt gaaatgatgg gaaccaacat tctttggatt tagtggggag cataatagca   2820

aacaccccct tggttcgcac atgtacagga atgggaccca gttggggcac agccatggac   2880

ttccccgccc tggaatgtgt ggtgcaaagt ggggccaggg cccagaccca agaggagagg   2940

gtggtccgca gacaccccgg gatgtcagca tcccccgacc tgccttctgg cggcacctcc   3000

cgggtgctgt gttgagtcag caggcatggg gtgagagcct ggtatatgct gggaacaggg   3060

tgcaggggcc aagcgttcct ccttcagcct tgacttgggc catgcacccc ctctccccca   3120

aacacaaaca agcacttctc cagtatggtg ccaggacagg tgtcccttca gtcctctggt   3180

tatgacctca agtcctactt gggccctgca gcccagcctg tgttgtaacc tctgcgtcct   3240

caagaccaca cctggaagat tcttcttccc tttgaaggag aatcatcatt gttgctttat   3300

cacttctaag acattttgta cggcacggac aagttaaaca gaatgtgctt ccctccctgg   3360

ggtctcacac gctcccacga gaatgccaca ggggccgtgc actgggcagg cttctctgta   3420

gaaccccagg ggcttcggcc cagaccacag cgtcttgccc tgagcctaga gcagggagtc   3480

ccgaacttct gcattcacag accacctcca caattgttat aaccaaaggc ctcctgttct   3540

gttatttcac ttaaatcaac atgctatttt gttttcactc acttctgact ttagcctcgt   3600

gctgagccgt gtatccatgc agtcatgttc acgtgctagt tacgtttttc ttcttacaca   3660

tgaaaataaa tgcataagtg ttagaagctc ttcc                               3694


<210>  5505
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  5505

Met Ala Ser Lys Pro Glu Lys Arg Val Ala Ser Ser Val Phe Ile Thr 
1               5                   10                  15      


Leu Ala Pro Pro Arg Arg Asp Val Ala Val Ala Glu Glu Val Arg Gln 
            20                  25                  30          


Ala Val Cys Glu Ala Arg Arg Gly Arg Pro Trp Glu Ala Pro Ala Pro 
        35                  40                  45              


Met Lys Thr Pro Glu Ala Gly Leu Ala Gly Arg Pro Ser Pro Trp Thr 
    50                  55                  60                  


Thr Pro Gly Arg Ala Ala Ala Thr Val Pro Ala Ala Pro Met Gln Leu 
65                  70                  75                  80  


Phe Asn Gly Gly Cys Pro Pro Pro Pro Pro Val Leu Asp Gly Glu Asp 
                85                  90                  95      


Val Leu Pro Asp Leu Asp Leu Leu Pro Pro Pro Pro Pro Pro Pro Pro 
            100                 105                 110         


Val Leu Leu Pro Ser Glu Glu Glu Ala Pro Ala Pro Met Gly Ala Ser 
        115                 120                 125             


Leu Ile Ala Asp Leu Glu Gln Leu His Leu Ser Pro Pro Pro Pro Pro 
    130                 135                 140                 


Pro Gln Ala Pro Ala Glu Gly Pro Ser Val Gln Pro Gly Pro Leu Arg 
145                 150                 155                 160 


Pro Met Glu Glu Glu Leu Pro Pro Pro Pro Ala Glu Pro Val Glu Lys 
                165                 170                 175     


Gly Ala Ser Thr Asp Ile Cys Ala Phe Cys His Lys Thr Val Ser Pro 
            180                 185                 190         


Arg Glu Leu Ala Val Glu Ala Met Lys Arg Gln Tyr His Ala Gln Cys 
        195                 200                 205             


Phe Thr Cys Arg Thr Cys Arg Arg Gln Leu Ala Gly Gln Ser Phe Tyr 
    210                 215                 220                 


Gln Lys Asp Gly Arg Pro Leu Cys Glu Pro Cys Tyr Gln Asp Thr Leu 
225                 230                 235                 240 


Glu Arg Cys Gly Lys Cys Gly Glu Val Val Arg Asp His Ile Ile Arg 
                245                 250                 255     


Ala Leu Gly Gln Ala Phe His Pro Ser Cys Phe Thr Cys Val Thr Cys 
            260                 265                 270         


Ala Arg Cys Ile Gly Asp Glu Ser Phe Ala Leu Gly Ser Gln Asn Glu 
        275                 280                 285             


Val Tyr Cys Leu Asp Asp Phe Tyr Arg Lys Phe Ala Pro Val Cys Ser 
    290                 295                 300                 


Ile Cys Glu Asn Pro Ile Ile Pro Arg Asp Gly Lys Asp Ala Phe Lys 
305                 310                 315                 320 


Ile Glu Cys Met Gly Arg Asn Phe His Glu Asn Cys Tyr Arg Cys Glu 
                325                 330                 335     


Asp Cys Arg Ile Leu Leu Ser Val Glu Pro Thr Asp Gln Gly Cys Tyr 
            340                 345                 350         


Pro Leu Asn Asn His Leu Phe Cys Lys Pro Cys His Val Lys Arg Ser 
        355                 360                 365             


Ala Ala Gly Cys Cys 
    370             


<210>  5506
<211>  3830
<212>  DNA
<213>  Homosapiens

<400>  5506
atgaagaacg cgaggggatg ggcagcgggg agggaaggaa acccaccccg actccccatt     60

ctcctacccc cactccccat ccctcccatt cccccatcgc ccccatcccc attccccccc    120

attcccaccc cctggcctgt gccaaggggg aggggaggcg tcgtccaggg aacaaaggga    180

gggggaaggg gcggcgcggg gcgcggccgg gcaggttggg gggcaggtag gggccgcttc    240

cgcggggcgg gaatcccgcg ccccctcccc ccgagcctca ccttttatgg taaagcggcg    300

cggggcggcg gggcggaggg agccgagggg gcggggaggg cggacgggcg gaggggacgg    360

gaggcccagc ggctccgggc tccgctggct cgggcgtcgg atcggagccg ccggggcgcg    420

ggcggcccag agctggcctg aacctccagg acttcagccc ttctaggaga atctgatccc    480

aggtgaggga ggtcacttgg ggtgtggccc agcaggcagg cgggactcca gactgggaac    540

ggaagtcagc cctgctgggg ctgggagctg aagcatctgt tccttcctcg cgggtgtgag    600

acaaggaaga gtgatcattg ccacaccagg agctgaagcc atggcctcaa agcctgagaa    660

gagggtggca tcgtctgtct ttatcaccct ggcacccccg cgccgcgatg tggccgtggc    720

ggaggaagtg aggcaggcag tttgtgaggc ccggcgtggc cgcccctggg aggctcctgc    780

ccccatgaag acacccgagg ctggcttggc ggggaggccc agcccctgga caacccctgg    840

cagagctgca gccacagtgc cggctgcacc tatgcagctc ttcaatggag gatgcccacc    900

ccctcctcct gtcctggatg gtgaggacgt gcttcctgac ctggacctcc tcccaccccc    960

tccaccgccc cctccagtgc ttctgccttc tgaagaggag gctcctgctc caatgggggc   1020

ctcactcatt gcagacttag agcagctgca cctgtccccg cccccgcccc caccacaggc   1080

cccagcggag ggaccttcag tccagcccgg tcccctcagg cccatggagg aagagctgcc   1140

acctcccccg gcagaacctg ttgagaaagg ggcatccaca gacatctgtg ccttctgcca   1200

caagaccgtg tccccccgag agctggctgt ggaggccatg aagaggcagt accatgccca   1260

gtgcttcacg tgccgcacct gccgccgcca gctggctggg cagagcttct accagaagga   1320

tgggcgaccc ctctgcgaac cctgctacca ggacacactg gagaggtgcg gcaagtgtgg   1380

cgaggtggtc cgggaccaca tcatcagggc cctgggccag gccttccacc cctcctgctt   1440

cacgtgtgtg acctgcgccc ggtgcattgg ggatgagagc tttgccctgg gcagccagaa   1500

cgaggtgtac tgcctggacg acttctacag gaaattcgcc cccgtctgca gcatctgtga   1560

aaatcccatc atccctcggg atgggaaaga tgccttcaaa atcgaatgca tgggaagaaa   1620

cttccatgaa aattgctaca ggtgtgagga ctgcaggatc ctcctgtctg tcgagcccac   1680

ggaccaaggc tgctaccccc tgaacaacca tctcttctgc aagccatgcc atgtgaagcg   1740

gagtgctgcg gggtgctgct gagagtgccc gctgggcagt gaacagacca ctagccccgg   1800

ctggggccct tccctgactt ggtttccctt cctaacctgc tcttgcacac tttccttctg   1860

agcctccatg gagaccagcc tgcaagccgg cccagcctgt ccaggataca gtggggctga   1920

gcacccccag gccttccact cctctaccct ctgggcacca gaaggctcct ggaccatgag   1980

cttcaccccc agaattccct gctgaccctg ccccacttcc agggaaaagc tgggggaggt   2040

tggacccctc tcactgacta gctgtctggt aggggtgcta ggaccagcct cgcctgtggg   2100

gttgagctgt ttgaggacaa actccaaggt cccttaaaaa gtgcctttta gaggctgggc   2160

atggtggctc acgcttgtaa tcccagcact ttgggaggcc aaggtgggtg gatcacctga   2220

ggtcaggagt tcaagaccag cctggccaac atggtgaaac cctgtctcta ctaaaaatac   2280

aaaaattagc caggcatggt agcaggtgcc tgtaatccca gctactgggg aaagctgagg   2340

caggagaatt gcttcaatct ggaaggcaga ggttgcagtg agattgcacc attgcattcc   2400

agcctgggca acaagaggga aactccgtct caaaaaaaaa aaagtgcctt ttaggccgga   2460

tgtggtggct catgcctgta atcccagcac tttgggaggc caaggcaggc agatcacttg   2520

aggtcaggag tttgagacca gcctggccaa cacggcaaaa ccccgtttct actaaaaata   2580

caaaaattag ctgggtgtgg tggcgtgcgc ctgtaatccc agctactcag gaggctgagg   2640

caggagcatt gcttgaaccc gggaggcaga ggttgcagtg agctgagatg gcaccactgc   2700

actccagcct gggagacaca gcgagactct gtctccaaaa aaaaaagtgc tttttgaaaa   2760

tgttgaggtt gaaatgatgg gaaccaacat tctttggatt tagtggggag cataatagca   2820

aacaccccct tggttcgcac atgtacagga atgggaccca gttggggcac agccatggac   2880

ttccccgccc tggaatgtgt ggtgcaaagt ggggccaggg cccagaccca agaggagagg   2940

gtggtccgca gacaccccgg gatgtcagca tcccccgacc tgccttctgg cggcacctcc   3000

cgggtgctgt gttgagtcag caggcatggg gtgagagcct ggtatatgct gggaacaggg   3060

tgcaggggcc aagcgttcct ccttcagcct tgacttgggc catgcacccc ctctccccca   3120

aacacaaaca agcacttctc cagtatggtg ccaggacagg tgtcccttca gtcctctggt   3180

tatgacctca agtcctactt gggccctgca gcccagcctg tgttgtaacc tctgcgtcct   3240

caagaccaca cctggaagat tcttcttccc tttgaaggag aatcatcatt gttgctttat   3300

cacttctaag acattttgta cggcacggac aagttaaaca gaatgtgctt ccctccctgg   3360

ggtctcacac gctcccacga gaatgccaca ggggccgtgc actgggcagg cttctctgta   3420

gaaccccagg ggcttcggcc cagaccacag cgtcttgccc tgagcctaga gcagggagtc   3480

ccgaacttct gcattcacag accacctcca caattgttat aaccaaaggc ctcctgttct   3540

gttatttcac ttaaatcaac atgctatttt gttttcactc acttctgact ttagcctcgt   3600

gctgagccgt gtatccatgc agtcatgttc acgtgctagt tacgtttttc ttcttacaca   3660

tgaaaataaa tgcataagtg ttagaagctc ttccatgttg tgtgtaggct ctcacacagg   3720

taaacgctgg cgtttggtag tagccctggg catctgctcg ctgtggcggg agtgtccgaa   3780

gagtgctggg gctcagctca gcagatggag gggctcattt cctgcctcat              3830


<210>  5507
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  5507

Met Ala Ser Lys Pro Glu Lys Arg Val Ala Ser Ser Val Phe Ile Thr 
1               5                   10                  15      


Leu Ala Pro Pro Arg Arg Asp Val Ala Val Ala Glu Glu Val Arg Gln 
            20                  25                  30          


Ala Val Cys Glu Ala Arg Arg Gly Arg Pro Trp Glu Ala Pro Ala Pro 
        35                  40                  45              


Met Lys Thr Pro Glu Ala Gly Leu Ala Gly Arg Pro Ser Pro Trp Thr 
    50                  55                  60                  


Thr Pro Gly Arg Ala Ala Ala Thr Val Pro Ala Ala Pro Met Gln Leu 
65                  70                  75                  80  


Phe Asn Gly Gly Cys Pro Pro Pro Pro Pro Val Leu Asp Gly Glu Asp 
                85                  90                  95      


Val Leu Pro Asp Leu Asp Leu Leu Pro Pro Pro Pro Pro Pro Pro Pro 
            100                 105                 110         


Val Leu Leu Pro Ser Glu Glu Glu Ala Pro Ala Pro Met Gly Ala Ser 
        115                 120                 125             


Leu Ile Ala Asp Leu Glu Gln Leu His Leu Ser Pro Pro Pro Pro Pro 
    130                 135                 140                 


Pro Gln Ala Pro Ala Glu Gly Pro Ser Val Gln Pro Gly Pro Leu Arg 
145                 150                 155                 160 


Pro Met Glu Glu Glu Leu Pro Pro Pro Pro Ala Glu Pro Val Glu Lys 
                165                 170                 175     


Gly Ala Ser Thr Asp Ile Cys Ala Phe Cys His Lys Thr Val Ser Pro 
            180                 185                 190         


Arg Glu Leu Ala Val Glu Ala Met Lys Arg Gln Tyr His Ala Gln Cys 
        195                 200                 205             


Phe Thr Cys Arg Thr Cys Arg Arg Gln Leu Ala Gly Gln Ser Phe Tyr 
    210                 215                 220                 


Gln Lys Asp Gly Arg Pro Leu Cys Glu Pro Cys Tyr Gln Asp Thr Leu 
225                 230                 235                 240 


Glu Arg Cys Gly Lys Cys Gly Glu Val Val Arg Asp His Ile Ile Arg 
                245                 250                 255     


Ala Leu Gly Gln Ala Phe His Pro Ser Cys Phe Thr Cys Val Thr Cys 
            260                 265                 270         


Ala Arg Cys Ile Gly Asp Glu Ser Phe Ala Leu Gly Ser Gln Asn Glu 
        275                 280                 285             


Val Tyr Cys Leu Asp Asp Phe Tyr Arg Lys Phe Ala Pro Val Cys Ser 
    290                 295                 300                 


Ile Cys Glu Asn Pro Ile Ile Pro Arg Asp Gly Lys Asp Ala Phe Lys 
305                 310                 315                 320 


Ile Glu Cys Met Gly Arg Asn Phe His Glu Asn Cys Tyr Arg Cys Glu 
                325                 330                 335     


Asp Cys Arg Ile Leu Leu Ser Val Glu Pro Thr Asp Gln Gly Cys Tyr 
            340                 345                 350         


Pro Leu Asn Asn His Leu Phe Cys Lys Pro Cys His Val Lys Arg Ser 
        355                 360                 365             


Ala Ala Gly Cys Cys 
    370             


<210>  5508
<211>  296
<212>  DNA
<213>  Homosapiens

<400>  5508
tccctcccat tcccccatcg cccccatccc cattcccccc ctggaggggc ctgcgggtgg     60

ggggtgcggt cctcacgccc tttgcgtccc agtctcttgg tctctctccc cggagtcggg    120

gagtcggcag gtccggggcg agggctcagt gaggccggcg gagggccgag tcccagcccg    180

ggagcgggag ccggggaccc ggcgcgcagg gcggaagctc ccgcacaaaa ggccggagtc    240

ccgcacatgg atcgaattaa agctccggcg gcgcccagcg gtgaccccgg cggccg        296


<210>  5509
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  5509

Pro Ser His Ser Pro Ile Ala Pro Ile Pro Ile Pro Pro Leu Glu Gly 
1               5                   10                  15      


Pro Ala Gly Gly Gly Cys Gly Pro His Ala Leu Cys Val Pro Val Ser 
            20                  25                  30          


Trp Ser Leu Ser Pro Glu Ser Gly Ser Arg Gln Val Arg Gly Glu Gly 
        35                  40                  45              


Ser Val Arg Pro Ala Glu Gly Arg Val Pro Ala Arg Glu Arg Glu Pro 
    50                  55                  60                  


Gly Thr Arg Arg Ala Gly Arg Lys Leu Pro His Lys Arg Pro Glu Ser 
65                  70                  75                  80  


Arg Thr Trp Ile Glu Leu Lys Leu Arg Arg Arg Pro Ala Val Thr Pro 
                85                  90                  95      


Ala 
    


<210>  5510
<211>  775
<212>  DNA
<213>  Homosapiens

<400>  5510
gaacctccag gacttcagcc cttctaggag aatctgatcc caggtgaggg aggtcacttg     60

gggtgtggcc cagcaggcag gcgggtgctg tgttgagtca gcaggcatgg ggtgagagcc    120

tggtatatgc tgggaacagg gtgcaggggc caagcgttcc tccttcagcc ttgacttggg    180

ccatgcaccc cctctccccc aaacacaaac aagcacttct ccagtatggt gccaggacag    240

gtgtcccttc agtcctctgg ttatgacctc aagtcctact tgggccctgc agcccagcct    300

gtgttgtaac ctctgcgtcc tcaagaccac acctggaaga ttcttcttcc ctttgaagga    360

gaatcatcat tgttgcttta tcacttctaa gacattttgt acggcacgga caagttaaac    420

agaatgtgct tccctccctg gggtctcaca cgctcccacg agaatgccac aggggccgtg    480

cactgggcag gcttctctgt agaaccccag gggcttcggc ccagaccaca gcgtcttgcc    540

ctgagcctag agcagggagt cccgaacttc tgcattcaca gaccacctcc acaattgtta    600

taaccaaagg cctcctgttc tgttatttca cttaaatcaa catgctattt tgttttcact    660

cacttctgac tttagcctcg tgctgagccg tgtatccatg cagtcatgtt cacgtgctag    720

ttacgttttt cttcttacac atgaaaataa atgcataagt gttagaagct cttcc         775


<210>  5511
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  5511

Met Cys Phe Pro Pro Trp Gly Leu Thr Arg Ser His Glu Asn Ala Thr 
1               5                   10                  15      


Gly Ala Val His Trp Ala Gly Phe Ser Val Glu Pro Gln Gly Leu Arg 
            20                  25                  30          


Pro Arg Pro Gln Arg Leu Ala Leu Ser Leu Glu Gln Gly Val Pro Asn 
        35                  40                  45              


Phe Cys Ile His Arg Pro Pro Pro Gln Leu Leu 
    50                  55                  


<210>  5512
<211>  911
<212>  DNA
<213>  Homosapiens

<400>  5512
gaacctccag gacttcagcc cttctaggag aatctgatcc caggtgaggg aggtcacttg     60

gggtgtggcc cagcaggcag gcgggtgctg tgttgagtca gcaggcatgg ggtgagagcc    120

tggtatatgc tgggaacagg gtgcaggggc caagcgttcc tccttcagcc ttgacttggg    180

ccatgcaccc cctctccccc aaacacaaac aagcacttct ccagtatggt gccaggacag    240

gtgtcccttc agtcctctgg ttatgacctc aagtcctact tgggccctgc agcccagcct    300

gtgttgtaac ctctgcgtcc tcaagaccac acctggaaga ttcttcttcc ctttgaagga    360

gaatcatcat tgttgcttta tcacttctaa gacattttgt acggcacgga caagttaaac    420

agaatgtgct tccctccctg gggtctcaca cgctcccacg agaatgccac aggggccgtg    480

cactgggcag gcttctctgt agaaccccag gggcttcggc ccagaccaca gcgtcttgcc    540

ctgagcctag agcagggagt cccgaacttc tgcattcaca gaccacctcc acaattgtta    600

taaccaaagg cctcctgttc tgttatttca cttaaatcaa catgctattt tgttttcact    660

cacttctgac tttagcctcg tgctgagccg tgtatccatg cagtcatgtt cacgtgctag    720

ttacgttttt cttcttacac atgaaaataa atgcataagt gttagaagct cttccatgtt    780

gtgtgtaggc tctcacacag gtaaacgctg gcgtttggta gtagccctgg gcatctgctc    840

gctgtggcgg gagtgtccga agagtgctgg ggctcagctc agcagatgga ggggctcatt    900

tcctgcctca t                                                         911


<210>  5513
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  5513

Met Gln Ser Cys Ser Arg Ala Ser Tyr Val Phe Leu Leu Thr His Glu 
1               5                   10                  15      


Asn Lys Cys Ile Ser Val Arg Ser Ser Ser Met Leu Cys Val Gly Ser 
            20                  25                  30          


His Thr Gly Lys Arg Trp Arg Leu Val Val Ala Leu Gly Ile Cys Ser 
        35                  40                  45              


Leu Trp Arg Glu Cys Pro Lys Ser Ala Gly Ala Gln Leu Ser Arg Trp 
    50                  55                  60                  


Arg Gly Ser Phe Pro Ala 
65                  70  


<210>  5514
<211>  1146
<212>  DNA
<213>  Homosapiens

<400>  5514
cctgggtgac aagagcaaaa aaaactccat ctcaaaaaaa aaaaaaaaaa aagaagtact     60

gaaaaaaaaa caaaaaagac agatgagatg ggtcccagcc ccactgaaca cagttctcaa    120

ttcagacaat ctccagtgac gctgggaaac caggtctcat tacacaggtc tctccacctg    180

ctcctgccaa gaagaaacag acatctctgc agtcccatag caacgggact gaaattgctc    240

aggaggaaat tcgcccccgt ctgcagcatc tgtgaaaatc ccatcatccc tcgggatggg    300

aaagatgcct tcaaaatcga atgcatggga agaaacttcc atgaaaattg ctacaggtgt    360

gaggactgca ggatcctcct gtctgtcgag cccacggacc aaggctgcta ccccctgaac    420

aaccatctct tctgcaagcc atgccatgtg aagcggagtg ctgcggggtg ctgctgagag    480

tgcccgctgg gcagtgaaca gaccactagc cccggctggg gcccttccct gacttggttt    540

cccttcctaa cctgctcttg cacactttcc ttctgagcct ccatggagac cagcctgcaa    600

gccggcccag cctgtccagg atacagtggg gctgagcacc cccaggcctt ccactcctct    660

accctctggg caccagaagg ctcctggacc atgagcttca cccccagaat tccctgctga    720

ccctgcccca cttccaggga aaagctgggg gaggttggac ccctctcact gactagctgt    780

ctggtagggg tgctaggacc agcctcgcct gtggggttga gctgtttgag gacaaactcc    840

aaggtccctt aaaaagtgcc ttttagaggc tgggcatggt ggctcacgct tgtaatccca    900

gcactttggg aggccaaggt gggtggatca cctgaggtca ggagttcaag accagcctgg    960

ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa ttagccaggc atggtagcag   1020

gtgcctgtaa tcccagctac tggggaaagc tgaggcagga gaattgcttc aatctggaag   1080

gcagaggttg cagtgagatt gcaccattgc attccagcct gggcaacaag agggaaactc   1140

cgtctc                                                              1146


<210>  5515
<211>  129
<212>  PRT
<213>  Homosapiens

<400>  5515

Met Gly Pro Ser Pro Thr Glu His Ser Ser Gln Phe Arg Gln Ser Pro 
1               5                   10                  15      


Val Thr Leu Gly Asn Gln Val Ser Leu His Arg Ser Leu His Leu Leu 
            20                  25                  30          


Leu Pro Arg Arg Asn Arg His Leu Cys Ser Pro Ile Ala Thr Gly Leu 
        35                  40                  45              


Lys Leu Leu Arg Arg Lys Phe Ala Pro Val Cys Ser Ile Cys Glu Asn 
    50                  55                  60                  


Pro Ile Ile Pro Arg Asp Gly Lys Asp Ala Phe Lys Ile Glu Cys Met 
65                  70                  75                  80  


Gly Arg Asn Phe His Glu Asn Cys Tyr Arg Cys Glu Asp Cys Arg Ile 
                85                  90                  95      


Leu Leu Ser Val Glu Pro Thr Asp Gln Gly Cys Tyr Pro Leu Asn Asn 
            100                 105                 110         


His Leu Phe Cys Lys Pro Cys His Val Lys Arg Ser Ala Ala Gly Cys 
        115                 120                 125             


Cys 
    


<210>  5516
<211>  2409
<212>  DNA
<213>  Homosapiens

<400>  5516
cctgggtgac aagagcaaaa aaaactccat ctcaaaaaaa aaaaaaaaaa aagaagtact     60

gaaaaaaaaa caaaaaagac agatgagatg ggtcccagcc ccactgaaca cagttctcaa    120

ttcagacaat ctccagtgac gctgggaaac caggtctcat tacacaggtc tctccacctg    180

ctcctgccaa gaagaaacag acatctctgc agtcccatag caacgggact gaaattgctc    240

aggaggaaat tcgcccccgt ctgcagcatc tgtgaaaatc ccatcatccc tcgggatggg    300

aaagatgcct tcaaaatcga atgcatggga agaaacttcc atgaaaattg ctacaggtgt    360

gaggactgca ggatcctcct gtctgtcgag cccacggacc aaggctgcta ccccctgaac    420

aaccatctct tctgcaagcc atgccatgtg aagcggagtg ctgcggggtg ctgctgagag    480

tgcccgctgg gcagtgaaca gaccactagc cccggctggg gcccttccct gacttggttt    540

cccttcctaa cctgctcttg cacactttcc ttctgagcct ccatggagac cagcctgcaa    600

gccggcccag cctgtccagg atacagtggg gctgagcacc cccaggcctt ccactcctct    660

accctctggg caccagaagg ctcctggacc atgagcttca cccccagaat tccctgctga    720

ccctgcccca cttccaggga aaagctgggg gaggttggac ccctctcact gactagctgt    780

ctggtagggg tgctaggacc agcctcgcct gtggggttga gctgtttgag gacaaactcc    840

aaggtccctt aaaaagtgcc ttttagaggc tgggcatggt ggctcacgct tgtaatccca    900

gcactttggg aggccaaggt gggtggatca cctgaggtca ggagttcaag accagcctgg    960

ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa ttagccaggc atggtagcag   1020

gtgcctgtaa tcccagctac tggggaaagc tgaggcagga gaattgcttc aatctggaag   1080

gcagaggttg cagtgagatt gcaccattgc attccagcct gggcaacaag agggaaactc   1140

cgtctcaaaa aaaaaaaagt gccttttagg ccggatgtgg tggctcatgc ctgtaatccc   1200

agcactttgg gaggccaagg caggcagatc acttgaggtc aggagtttga gaccagcctg   1260

gccaacacgg caaaaccccg tttctactaa aaatacaaaa attagctggg tgtggtggcg   1320

tgcgcctgta atcccagcta ctcaggaggc tgaggcagga gcattgcttg aacccgggag   1380

gcagaggttg cagtgagctg agatggcacc actgcactcc agcctgggag acacagcgag   1440

actctgtctc caaaaaaaaa agtgcttttt gaaaatgttg aggttgaaat gatgggaacc   1500

aacattcttt ggatttagtg gggagcataa tagcaaacac ccccttggtt cgcacatgta   1560

caggaatggg acccagttgg ggcacagcca tggacttccc cgccctggaa tgtgtggtgc   1620

aaagtggggc cagggcccag acccaagagg agagggtggt ccgcagacac cccgggatgt   1680

cagcatcccc cgacctgcct tctggcggca cctcccgggt gctgtgttga gtcagcaggc   1740

atggggtgag agcctggtat atgctgggaa cagggtgcag gggccaagcg ttcctccttc   1800

agccttgact tgggccatgc accccctctc ccccaaacac aaacaagcac ttctccagta   1860

tggtgccagg acaggtgtcc cttcagtcct ctggttatga cctcaagtcc tacttgggcc   1920

ctgcagccca gcctgtgttg taacctctgc gtcctcaaga ccacacctgg aagattcttc   1980

ttccctttga aggagaatca tcattgttgc tttatcactt ctaagacatt ttgtacggca   2040

cggacaagtt aaacagaatg tgcttccctc cctggggtct cacacgctcc cacgagaatg   2100

ccacaggggc cgtgcactgg gcaggcttct ctgtagaacc ccaggggctt cggcccagac   2160

cacagcgtct tgccctgagc ctagagcagg gagtcccgaa cttctgcatt cacagaccac   2220

ctccacaatt gttataacca aaggcctcct gttctgttat ttcacttaaa tcaacatgct   2280

attttgtttt cactcacttc tgactttagc ctcgtgctga gccgtgtatc catgcagtca   2340

tgttcacgtg ctagttacgt ttttcttctt acacatgaaa ataaatgcat aagtgttaga   2400

agctcttcc                                                           2409


<210>  5517
<211>  129
<212>  PRT
<213>  Homosapiens

<400>  5517

Met Gly Pro Ser Pro Thr Glu His Ser Ser Gln Phe Arg Gln Ser Pro 
1               5                   10                  15      


Val Thr Leu Gly Asn Gln Val Ser Leu His Arg Ser Leu His Leu Leu 
            20                  25                  30          


Leu Pro Arg Arg Asn Arg His Leu Cys Ser Pro Ile Ala Thr Gly Leu 
        35                  40                  45              


Lys Leu Leu Arg Arg Lys Phe Ala Pro Val Cys Ser Ile Cys Glu Asn 
    50                  55                  60                  


Pro Ile Ile Pro Arg Asp Gly Lys Asp Ala Phe Lys Ile Glu Cys Met 
65                  70                  75                  80  


Gly Arg Asn Phe His Glu Asn Cys Tyr Arg Cys Glu Asp Cys Arg Ile 
                85                  90                  95      


Leu Leu Ser Val Glu Pro Thr Asp Gln Gly Cys Tyr Pro Leu Asn Asn 
            100                 105                 110         


His Leu Phe Cys Lys Pro Cys His Val Lys Arg Ser Ala Ala Gly Cys 
        115                 120                 125             


Cys 
    


<210>  5518
<211>  2545
<212>  DNA
<213>  Homosapiens

<400>  5518
cctgggtgac aagagcaaaa aaaactccat ctcaaaaaaa aaaaaaaaaa aagaagtact     60

gaaaaaaaaa caaaaaagac agatgagatg ggtcccagcc ccactgaaca cagttctcaa    120

ttcagacaat ctccagtgac gctgggaaac caggtctcat tacacaggtc tctccacctg    180

ctcctgccaa gaagaaacag acatctctgc agtcccatag caacgggact gaaattgctc    240

aggaggaaat tcgcccccgt ctgcagcatc tgtgaaaatc ccatcatccc tcgggatggg    300

aaagatgcct tcaaaatcga atgcatggga agaaacttcc atgaaaattg ctacaggtgt    360

gaggactgca ggatcctcct gtctgtcgag cccacggacc aaggctgcta ccccctgaac    420

aaccatctct tctgcaagcc atgccatgtg aagcggagtg ctgcggggtg ctgctgagag    480

tgcccgctgg gcagtgaaca gaccactagc cccggctggg gcccttccct gacttggttt    540

cccttcctaa cctgctcttg cacactttcc ttctgagcct ccatggagac cagcctgcaa    600

gccggcccag cctgtccagg atacagtggg gctgagcacc cccaggcctt ccactcctct    660

accctctggg caccagaagg ctcctggacc atgagcttca cccccagaat tccctgctga    720

ccctgcccca cttccaggga aaagctgggg gaggttggac ccctctcact gactagctgt    780

ctggtagggg tgctaggacc agcctcgcct gtggggttga gctgtttgag gacaaactcc    840

aaggtccctt aaaaagtgcc ttttagaggc tgggcatggt ggctcacgct tgtaatccca    900

gcactttggg aggccaaggt gggtggatca cctgaggtca ggagttcaag accagcctgg    960

ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa ttagccaggc atggtagcag   1020

gtgcctgtaa tcccagctac tggggaaagc tgaggcagga gaattgcttc aatctggaag   1080

gcagaggttg cagtgagatt gcaccattgc attccagcct gggcaacaag agggaaactc   1140

cgtctcaaaa aaaaaaaagt gccttttagg ccggatgtgg tggctcatgc ctgtaatccc   1200

agcactttgg gaggccaagg caggcagatc acttgaggtc aggagtttga gaccagcctg   1260

gccaacacgg caaaaccccg tttctactaa aaatacaaaa attagctggg tgtggtggcg   1320

tgcgcctgta atcccagcta ctcaggaggc tgaggcagga gcattgcttg aacccgggag   1380

gcagaggttg cagtgagctg agatggcacc actgcactcc agcctgggag acacagcgag   1440

actctgtctc caaaaaaaaa agtgcttttt gaaaatgttg aggttgaaat gatgggaacc   1500

aacattcttt ggatttagtg gggagcataa tagcaaacac ccccttggtt cgcacatgta   1560

caggaatggg acccagttgg ggcacagcca tggacttccc cgccctggaa tgtgtggtgc   1620

aaagtggggc cagggcccag acccaagagg agagggtggt ccgcagacac cccgggatgt   1680

cagcatcccc cgacctgcct tctggcggca cctcccgggt gctgtgttga gtcagcaggc   1740

atggggtgag agcctggtat atgctgggaa cagggtgcag gggccaagcg ttcctccttc   1800

agccttgact tgggccatgc accccctctc ccccaaacac aaacaagcac ttctccagta   1860

tggtgccagg acaggtgtcc cttcagtcct ctggttatga cctcaagtcc tacttgggcc   1920

ctgcagccca gcctgtgttg taacctctgc gtcctcaaga ccacacctgg aagattcttc   1980

ttccctttga aggagaatca tcattgttgc tttatcactt ctaagacatt ttgtacggca   2040

cggacaagtt aaacagaatg tgcttccctc cctggggtct cacacgctcc cacgagaatg   2100

ccacaggggc cgtgcactgg gcaggcttct ctgtagaacc ccaggggctt cggcccagac   2160

cacagcgtct tgccctgagc ctagagcagg gagtcccgaa cttctgcatt cacagaccac   2220

ctccacaatt gttataacca aaggcctcct gttctgttat ttcacttaaa tcaacatgct   2280

attttgtttt cactcacttc tgactttagc ctcgtgctga gccgtgtatc catgcagtca   2340

tgttcacgtg ctagttacgt ttttcttctt acacatgaaa ataaatgcat aagtgttaga   2400

agctcttcca tgttgtgtgt aggctctcac acaggtaaac gctggcgttt ggtagtagcc   2460

ctgggcatct gctcgctgtg gcgggagtgt ccgaagagtg ctggggctca gctcagcaga   2520

tggaggggct catttcctgc ctcat                                         2545


<210>  5519
<211>  129
<212>  PRT
<213>  Homosapiens

<400>  5519

Met Gly Pro Ser Pro Thr Glu His Ser Ser Gln Phe Arg Gln Ser Pro 
1               5                   10                  15      


Val Thr Leu Gly Asn Gln Val Ser Leu His Arg Ser Leu His Leu Leu 
            20                  25                  30          


Leu Pro Arg Arg Asn Arg His Leu Cys Ser Pro Ile Ala Thr Gly Leu 
        35                  40                  45              


Lys Leu Leu Arg Arg Lys Phe Ala Pro Val Cys Ser Ile Cys Glu Asn 
    50                  55                  60                  


Pro Ile Ile Pro Arg Asp Gly Lys Asp Ala Phe Lys Ile Glu Cys Met 
65                  70                  75                  80  


Gly Arg Asn Phe His Glu Asn Cys Tyr Arg Cys Glu Asp Cys Arg Ile 
                85                  90                  95      


Leu Leu Ser Val Glu Pro Thr Asp Gln Gly Cys Tyr Pro Leu Asn Asn 
            100                 105                 110         


His Leu Phe Cys Lys Pro Cys His Val Lys Arg Ser Ala Ala Gly Cys 
        115                 120                 125             


Cys 
    


<210>  5520
<211>  949
<212>  DNA
<213>  Homosapiens

<400>  5520
gtggttgtgg catgaacgcc tcccaagcat gggttccttt gcttctagga aattcgcccc     60

cgtctgcagc atctgtgaaa atcccatcat ccctcgggat gggaaagatg ccttcaaaat    120

cgaatgcatg ggaagaaact tccatgaaaa ttgctacagg tgtgaggact gcaggatcct    180

cctgtctgtc gagcccacgg accaaggctg ctaccccctg aacaaccatc tcttctgcaa    240

gccatgccat gtgaagcgga gtgctgcggg gtgctgctga gagtgcccgc tgggcagtga    300

acagaccact agccccggct ggggcccttc cctgacttgg tttcccttcc taacctgctc    360

ttgcacactt tccttctgag cctccatgga gaccagcctg caagccggcc cagcctgtcc    420

aggatacagt ggggctgagc acccccaggc cttccactcc tctaccctct gggcaccaga    480

aggctcctgg accatgagct tcacccccag aattccctgc tgaccctgcc ccacttccag    540

ggaaaagctg ggggaggttg gacccctctc actgactagc tgtctggtag gggtgctagg    600

accagcctcg cctgtggggt tgagctgttt gaggacaaac tccaaggtcc cttaaaaagt    660

gccttttaga ggctgggcat ggtggctcac gcttgtaatc ccagcacttt gggaggccaa    720

ggtgggtgga tcacctgagg tcaggagttc aagaccagcc tggccaacat ggtgaaaccc    780

tgtctctact aaaaatacaa aaattagcca ggcatggtag caggtgcctg taatcccagc    840

tactggggaa agctgaggca ggagaattgc ttcaatctgg aaggcagagg ttgcagtgag    900

attgcaccat tgcattccag cctgggcaac aagagggaaa ctccgtctc                949


<210>  5521
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  5521

Met Gly Ser Phe Ala Ser Arg Lys Phe Ala Pro Val Cys Ser Ile Cys 
1               5                   10                  15      


Glu Asn Pro Ile Ile Pro Arg Asp Gly Lys Asp Ala Phe Lys Ile Glu 
            20                  25                  30          


Cys Met Gly Arg Asn Phe His Glu Asn Cys Tyr Arg Cys Glu Asp Cys 
        35                  40                  45              


Arg Ile Leu Leu Ser Val Glu Pro Thr Asp Gln Gly Cys Tyr Pro Leu 
    50                  55                  60                  


Asn Asn His Leu Phe Cys Lys Pro Cys His Val Lys Arg Ser Ala Ala 
65                  70                  75                  80  


Gly Cys Cys 
            


<210>  5522
<211>  2212
<212>  DNA
<213>  Homosapiens

<400>  5522
gtggttgtgg catgaacgcc tcccaagcat gggttccttt gcttctagga aattcgcccc     60

cgtctgcagc atctgtgaaa atcccatcat ccctcgggat gggaaagatg ccttcaaaat    120

cgaatgcatg ggaagaaact tccatgaaaa ttgctacagg tgtgaggact gcaggatcct    180

cctgtctgtc gagcccacgg accaaggctg ctaccccctg aacaaccatc tcttctgcaa    240

gccatgccat gtgaagcgga gtgctgcggg gtgctgctga gagtgcccgc tgggcagtga    300

acagaccact agccccggct ggggcccttc cctgacttgg tttcccttcc taacctgctc    360

ttgcacactt tccttctgag cctccatgga gaccagcctg caagccggcc cagcctgtcc    420

aggatacagt ggggctgagc acccccaggc cttccactcc tctaccctct gggcaccaga    480

aggctcctgg accatgagct tcacccccag aattccctgc tgaccctgcc ccacttccag    540

ggaaaagctg ggggaggttg gacccctctc actgactagc tgtctggtag gggtgctagg    600

accagcctcg cctgtggggt tgagctgttt gaggacaaac tccaaggtcc cttaaaaagt    660

gccttttaga ggctgggcat ggtggctcac gcttgtaatc ccagcacttt gggaggccaa    720

ggtgggtgga tcacctgagg tcaggagttc aagaccagcc tggccaacat ggtgaaaccc    780

tgtctctact aaaaatacaa aaattagcca ggcatggtag caggtgcctg taatcccagc    840

tactggggaa agctgaggca ggagaattgc ttcaatctgg aaggcagagg ttgcagtgag    900

attgcaccat tgcattccag cctgggcaac aagagggaaa ctccgtctca aaaaaaaaaa    960

agtgcctttt aggccggatg tggtggctca tgcctgtaat cccagcactt tgggaggcca   1020

aggcaggcag atcacttgag gtcaggagtt tgagaccagc ctggccaaca cggcaaaacc   1080

ccgtttctac taaaaataca aaaattagct gggtgtggtg gcgtgcgcct gtaatcccag   1140

ctactcagga ggctgaggca ggagcattgc ttgaacccgg gaggcagagg ttgcagtgag   1200

ctgagatggc accactgcac tccagcctgg gagacacagc gagactctgt ctccaaaaaa   1260

aaaagtgctt tttgaaaatg ttgaggttga aatgatggga accaacattc tttggattta   1320

gtggggagca taatagcaaa cacccccttg gttcgcacat gtacaggaat gggacccagt   1380

tggggcacag ccatggactt ccccgccctg gaatgtgtgg tgcaaagtgg ggccagggcc   1440

cagacccaag aggagagggt ggtccgcaga caccccggga tgtcagcatc ccccgacctg   1500

ccttctggcg gcacctcccg ggtgctgtgt tgagtcagca ggcatggggt gagagcctgg   1560

tatatgctgg gaacagggtg caggggccaa gcgttcctcc ttcagccttg acttgggcca   1620

tgcaccccct ctcccccaaa cacaaacaag cacttctcca gtatggtgcc aggacaggtg   1680

tcccttcagt cctctggtta tgacctcaag tcctacttgg gccctgcagc ccagcctgtg   1740

ttgtaacctc tgcgtcctca agaccacacc tggaagattc ttcttccctt tgaaggagaa   1800

tcatcattgt tgctttatca cttctaagac attttgtacg gcacggacaa gttaaacaga   1860

atgtgcttcc ctccctgggg tctcacacgc tcccacgaga atgccacagg ggccgtgcac   1920

tgggcaggct tctctgtaga accccagggg cttcggccca gaccacagcg tcttgccctg   1980

agcctagagc agggagtccc gaacttctgc attcacagac cacctccaca attgttataa   2040

ccaaaggcct cctgttctgt tatttcactt aaatcaacat gctattttgt tttcactcac   2100

ttctgacttt agcctcgtgc tgagccgtgt atccatgcag tcatgttcac gtgctagtta   2160

cgtttttctt cttacacatg aaaataaatg cataagtgtt agaagctctt cc           2212


<210>  5523
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  5523

Met Gly Ser Phe Ala Ser Arg Lys Phe Ala Pro Val Cys Ser Ile Cys 
1               5                   10                  15      


Glu Asn Pro Ile Ile Pro Arg Asp Gly Lys Asp Ala Phe Lys Ile Glu 
            20                  25                  30          


Cys Met Gly Arg Asn Phe His Glu Asn Cys Tyr Arg Cys Glu Asp Cys 
        35                  40                  45              


Arg Ile Leu Leu Ser Val Glu Pro Thr Asp Gln Gly Cys Tyr Pro Leu 
    50                  55                  60                  


Asn Asn His Leu Phe Cys Lys Pro Cys His Val Lys Arg Ser Ala Ala 
65                  70                  75                  80  


Gly Cys Cys 
            


<210>  5524
<211>  2348
<212>  DNA
<213>  Homosapiens

<400>  5524
gtggttgtgg catgaacgcc tcccaagcat gggttccttt gcttctagga aattcgcccc     60

cgtctgcagc atctgtgaaa atcccatcat ccctcgggat gggaaagatg ccttcaaaat    120

cgaatgcatg ggaagaaact tccatgaaaa ttgctacagg tgtgaggact gcaggatcct    180

cctgtctgtc gagcccacgg accaaggctg ctaccccctg aacaaccatc tcttctgcaa    240

gccatgccat gtgaagcgga gtgctgcggg gtgctgctga gagtgcccgc tgggcagtga    300

acagaccact agccccggct ggggcccttc cctgacttgg tttcccttcc taacctgctc    360

ttgcacactt tccttctgag cctccatgga gaccagcctg caagccggcc cagcctgtcc    420

aggatacagt ggggctgagc acccccaggc cttccactcc tctaccctct gggcaccaga    480

aggctcctgg accatgagct tcacccccag aattccctgc tgaccctgcc ccacttccag    540

ggaaaagctg ggggaggttg gacccctctc actgactagc tgtctggtag gggtgctagg    600

accagcctcg cctgtggggt tgagctgttt gaggacaaac tccaaggtcc cttaaaaagt    660

gccttttaga ggctgggcat ggtggctcac gcttgtaatc ccagcacttt gggaggccaa    720

ggtgggtgga tcacctgagg tcaggagttc aagaccagcc tggccaacat ggtgaaaccc    780

tgtctctact aaaaatacaa aaattagcca ggcatggtag caggtgcctg taatcccagc    840

tactggggaa agctgaggca ggagaattgc ttcaatctgg aaggcagagg ttgcagtgag    900

attgcaccat tgcattccag cctgggcaac aagagggaaa ctccgtctca aaaaaaaaaa    960

agtgcctttt aggccggatg tggtggctca tgcctgtaat cccagcactt tgggaggcca   1020

aggcaggcag atcacttgag gtcaggagtt tgagaccagc ctggccaaca cggcaaaacc   1080

ccgtttctac taaaaataca aaaattagct gggtgtggtg gcgtgcgcct gtaatcccag   1140

ctactcagga ggctgaggca ggagcattgc ttgaacccgg gaggcagagg ttgcagtgag   1200

ctgagatggc accactgcac tccagcctgg gagacacagc gagactctgt ctccaaaaaa   1260

aaaagtgctt tttgaaaatg ttgaggttga aatgatggga accaacattc tttggattta   1320

gtggggagca taatagcaaa cacccccttg gttcgcacat gtacaggaat gggacccagt   1380

tggggcacag ccatggactt ccccgccctg gaatgtgtgg tgcaaagtgg ggccagggcc   1440

cagacccaag aggagagggt ggtccgcaga caccccggga tgtcagcatc ccccgacctg   1500

ccttctggcg gcacctcccg ggtgctgtgt tgagtcagca ggcatggggt gagagcctgg   1560

tatatgctgg gaacagggtg caggggccaa gcgttcctcc ttcagccttg acttgggcca   1620

tgcaccccct ctcccccaaa cacaaacaag cacttctcca gtatggtgcc aggacaggtg   1680

tcccttcagt cctctggtta tgacctcaag tcctacttgg gccctgcagc ccagcctgtg   1740

ttgtaacctc tgcgtcctca agaccacacc tggaagattc ttcttccctt tgaaggagaa   1800

tcatcattgt tgctttatca cttctaagac attttgtacg gcacggacaa gttaaacaga   1860

atgtgcttcc ctccctgggg tctcacacgc tcccacgaga atgccacagg ggccgtgcac   1920

tgggcaggct tctctgtaga accccagggg cttcggccca gaccacagcg tcttgccctg   1980

agcctagagc agggagtccc gaacttctgc attcacagac cacctccaca attgttataa   2040

ccaaaggcct cctgttctgt tatttcactt aaatcaacat gctattttgt tttcactcac   2100

ttctgacttt agcctcgtgc tgagccgtgt atccatgcag tcatgttcac gtgctagtta   2160

cgtttttctt cttacacatg aaaataaatg cataagtgtt agaagctctt ccatgttgtg   2220

tgtaggctct cacacaggta aacgctggcg tttggtagta gccctgggca tctgctcgct   2280

gtggcgggag tgtccgaaga gtgctggggc tcagctcagc agatggaggg gctcatttcc   2340

tgcctcat                                                            2348


<210>  5525
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  5525

Met Gly Ser Phe Ala Ser Arg Lys Phe Ala Pro Val Cys Ser Ile Cys 
1               5                   10                  15      


Glu Asn Pro Ile Ile Pro Arg Asp Gly Lys Asp Ala Phe Lys Ile Glu 
            20                  25                  30          


Cys Met Gly Arg Asn Phe His Glu Asn Cys Tyr Arg Cys Glu Asp Cys 
        35                  40                  45              


Arg Ile Leu Leu Ser Val Glu Pro Thr Asp Gln Gly Cys Tyr Pro Leu 
    50                  55                  60                  


Asn Asn His Leu Phe Cys Lys Pro Cys His Val Lys Arg Ser Ala Ala 
65                  70                  75                  80  


Gly Cys Cys 
            


<210>  5526
<211>  814
<212>  DNA
<213>  Homosapiens

<400>  5526
cttgaacttc tggattcaag tgatccgccc tcctcggcct cccaaagtgc tgggactaca     60

ggcttgagcc acctcgccca gctgaaagtg acactttaat actttcagga aattatagga    120

gatgattgtt aagagctcag gataaagaga agtttctggc cgggaacggt ggctcacacc    180

tgtaatccca gcactttcag tggcggagca cctgtggcca agagtttgag accagcctgg    240

ccaacatggt gaaaccccat ctctactaaa aatacaaaaa ttgaggtgcc gctgttgctg    300

ctcgtgttaa atctagaacc gtagccagac atgggactgg aggacgagca aaagatgctt    360

accgaatccg gagatcctga ggaggaggaa gaggaagagg aggaattagt ggatccccta    420

acaacagtga gagagcaatg cgagcagttg gagaaatgtg taaaggcccg ggagcggcta    480

gagctctatg atgagcatgt atcctctcga tcacatacag aagaggattg cacggaggag    540

ctctttgact tcttgcatgc aaaggaccat tgcgtggccc acaaactctt taacaacttg    600

aaataaatgt gtggacttaa ttcaccccag ccttcatcat ctgggcatca gaatatttcc    660

ttatggtttc ggatgtacca tttgtttctt atttgtgtaa ctgtaagttc acatgaacct    720

cgtgggtttt ggcttaggct ggtagcttct atgtaattcg cagtgattcc atctaaataa    780

aagttctgtg atctgcaaaa aaaaaaaaaa atta                                814


<210>  5527
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  5527

Met Gly Leu Glu Asp Glu Gln Lys Met Leu Thr Glu Ser Gly Asp Pro 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Leu Val Asp Pro Leu Thr Thr 
            20                  25                  30          


Val Arg Glu Gln Cys Glu Gln Leu Glu Lys Cys Val Lys Ala Arg Glu 
        35                  40                  45              


Arg Leu Glu Leu Tyr Asp Glu His Val Ser Ser Arg Ser His Thr Glu 
    50                  55                  60                  


Glu Asp Cys Thr Glu Glu Leu Phe Asp Phe Leu His Ala Lys Asp His 
65                  70                  75                  80  


Cys Val Ala His Lys Leu Phe Asn Asn Leu Lys 
                85                  90      


<210>  5528
<211>  2165
<212>  DNA
<213>  Homosapiens

<400>  5528
gtgagactct gtctcaaaaa caaaacaaaa caaaaacaga aagaatcaga gtcaacaaat     60

cagtatggat gcagattcct cagatgccag gaatcccagg ataaatggca ggggtgaacc    120

aaatacttcc cattcttccc tcaccaccct cctccatcca ataaagaagt aaataaattc    180

ctcaagtccc ctctgcccca gtgcatggaa tgtttacctg tggactagga ctggtctaca    240

tgccaaacag gccttgcctc ctgggcggca tgtttgcagg ggatccttgc tgatgatgtt    300

ggcctcctcc tgcaccctcc cactccatgg ctgtctcacc tgagagagct ttcttccttt    360

tgcattaagt gtgagtcctg ataaattcaa aaaagcctcc aggtgacatc attttaacac    420

cagttaacaa tcacaaatct gggtgaatga gcctcagagt ttttcttgac agtagtgtgc    480

gtgcgtgtgt gtgtgcgtgt tttccatgga aaaataaaat gtattacaca aactatcagt    540

attaattaca gaaaggtggc caggtgcagt gcctcacgcc tgtaatcctg gcactttggg    600

aggccaaggc gggcagattg cctgagctca ggagtttgag accagcctgg tcaaacatgg    660

tgaaaccctg tatctactaa aaatacaaaa cattagctgg gcgtggtggc gcatgcctgt    720

agtctcaggt actcggaagg gtgaggcaca agaatcgctt gagtctggaa ggtggaggtt    780

gcagtgagcc gagaacacgc cactaaactc cagccggggt gacagagcaa gactctgtct    840

caaaaaacaa acaaacaatt aattacagaa aggtaagcct ggccaatagg tcaggaaaag    900

cagccccact gcagatccac accactacgg aaacttgagg caccacacac atgactttgc    960

tgactggggg caaaggatga actagtgagc aaacttggga ggctgagaca ggaggatcgc   1020

ttgaacctgg gaggtagagg ttgcagtgag ccaagatcgc accactgctc tccagccagg   1080

tgacagagcg agactccagc tcaaaaaaaa aaaaaaagtc aagatattaa atatgaaagc   1140

aacactttat tttttatttt attttatttt aagacagggt ctctctctgt cacccagact   1200

ggagtacagt gacatgatct ctgctcactg tgatctctgc ctcccaggct caaactatcc   1260

tcccacatca gcctcccaaa tagctgggac tacaggggcc caccaccaca cctgactaat   1320

ttttgtattt ttggtagaga tgcggtttca ccatgttgcc cagcctgatc ttgaacttct   1380

ggattcaagt gatccgccct cctcggcctc ccaaagtgct gggactacag gcttgagcca   1440

cctcgcccag ctgaaagtga cactttaata ctttcaggaa attataggag atgattgtta   1500

agagctcagg ataaagagaa gtttctggcc gggaacggtg gctcacacct gtaatcccag   1560

cactttcagt ggcggagcac ctgtggccaa gagtttgaga ccagcctggc caacatggtg   1620

aaaccccatc tctactaaaa atacaaaaat tgaggtgccg ctgttgctgc tcgtgttaaa   1680

tctagaaccg tagccagaca tgggactgga ggacgagcaa aagatgctta ccgaatccgg   1740

agatcctgag gaggaggaag aggaagagga ggaattagtg gatcccctaa caacagtgag   1800

agagcaatgc gagcagttgg agaaatgtgt aaaggcccgg gagcggctag agctctatga   1860

tgagcatgta tcctctcgat cacatacaga agaggattgc acggaggagc tctttgactt   1920

cttgcatgca aaggaccatt gcgtggccca caaactcttt aacaacttga aataaatgtg   1980

tggacttaat tcaccccagc cttcatcatc tgggcatcag aatatttcct tatggtttcg   2040

gatgtaccat ttgtttctta tttgtgtaac tgtaagttca catgaacctc gtgggttttg   2100

gcttaggctg gtagcttcta tgtaattcgc agtgattcca tctaaataaa agttctgtga   2160

tctgc                                                               2165


<210>  5529
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  5529

Met Gly Leu Glu Asp Glu Gln Lys Met Leu Thr Glu Ser Gly Asp Pro 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Leu Val Asp Pro Leu Thr Thr 
            20                  25                  30          


Val Arg Glu Gln Cys Glu Gln Leu Glu Lys Cys Val Lys Ala Arg Glu 
        35                  40                  45              


Arg Leu Glu Leu Tyr Asp Glu His Val Ser Ser Arg Ser His Thr Glu 
    50                  55                  60                  


Glu Asp Cys Thr Glu Glu Leu Phe Asp Phe Leu His Ala Lys Asp His 
65                  70                  75                  80  


Cys Val Ala His Lys Leu Phe Asn Asn Leu Lys 
                85                  90      


<210>  5530
<211>  232
<212>  DNA
<213>  Homosapiens

<400>  5530
aggtgccgct gttgctgctc gtgttaaatc tagaaccgta gccagacatg ggactggagg     60

acgagcaaaa gatgcttacc gaatccggag atcctgagga ggaggaagag gaagaggagg    120

aattagtgga tcccccacaa actctttaac aacttgaaat aaatgtgtgg acttaattca    180

ccccagcctt catcatctgg gcatcagaat atttccttat ggtttcggat gt            232


<210>  5531
<211>  33
<212>  PRT
<213>  Homosapiens

<400>  5531

Met Gly Leu Glu Asp Glu Gln Lys Met Leu Thr Glu Ser Gly Asp Pro 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Leu Val Asp Pro Pro Gln Thr 
            20                  25                  30          


Leu 
    


<210>  5532
<211>  1103
<212>  DNA
<213>  Homosapiens

<400>  5532
tgttaccatt gttgttgaac aaggcagtgg gggaaaaagt agttaagatt atgtggcacg     60

atccttcaac atgacccaga actgggccat aggaaacttg tacagactat cacatcagat    120

gatggagaga aacatcactg agaatgcata aatccccgga ggcagaatgg ttaatttcgt    180

gaggcacagt catgtctaga caaatctggt ggggctattt agaaaaacac atatggtact    240

tctggcttta caaggaaggg gaccaagtca cattactcag caaatatctt tccttagtct    300

gaacttggct tctaagattt tctgagaact gagctttttt tttttctttt ttttgagatg    360

aagtttcgct cttgttgccc aggctggagt gcaatgatgt gatcccggct cactgcaacc    420

tcagcttggg tgacagagtg agactttatc tcaaaaaaca aacaaacaaa aaaacaacac    480

agacagttct gtaatactat atggttttat agggcaaaac tattttgtaa aatattatta    540

tactccatcc atgaatttca aagcagttga cagaatcatt agagtcttgg tgtattcctc    600

tatgctttta aaaaaatcca tttaagaaat aaaaaagccg ggcatggtgg ctcacgcctg    660

taatcccagc actttgggag gccgaggcat gtggatcaca aggtcaggag attgagacca    720

tcatggctaa cacggtgaaa ccccatctct actaaaaata caaaacatta gctgggcatg    780

gtggtgggcg cctgtagtcc cagctactcg ggaggctgag gcaggagaat ggtgtgaacc    840

cgggaggcgg agcttgcagt gagccaagat tgtgccactg cactccagcc tgggcgacag    900

agcgagactc tgtctcaaaa acaaaaaaaa gaaaagaagt aaaaaaagcc gggcgtggtg    960

gctcatgcct gtaatcccag cactttggga ggccgaggcg agcagatcac gaggtcagga   1020

gtttgagacc agcctggcca agatagtgaa accccatctc tactaaaaat acaaaaaatt   1080

agctgggcgt ggtggggggc atc                                           1103


<210>  5533
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  5533

Met Ser Arg Gln Ile Trp Trp Gly Tyr Leu Glu Lys His Ile Trp Tyr 
1               5                   10                  15      


Phe Trp Leu Tyr Lys Glu Gly Asp Gln Val Thr Leu Leu Ser Lys Tyr 
            20                  25                  30          


Leu Ser Leu Val 
        35      


<210>  5534
<211>  410
<212>  DNA
<213>  Homosapiens

<400>  5534
tctagtccac gcccgcagcc atgccgacca agggcccgct gcagtcggtg caggtcttcg     60

gacgcaagaa gacagccaca gctgtggcgc actgcaaacg cggcaatggt ctcatcaagc    120

tgctggagcc agttctgctt ctcggcaagg agcggtttgc tggtgtggac atctgtgtcc    180

gtatgaaggg tggtggtcac gtggcccaga tttatgctat ccatcagtcc atctccaaag    240

ccctggtggc ctactaccag aaatatgtgg atgaggcttc caagaaggag atcaaagaca    300

tcctcatcca gtatgaccag accctgctgg tagctgatcc tcgttgccgg gagtccaaaa    360

agtttggagg ccctggtgcc catgctcgct accagaaatc ctaccgataa               410


<210>  5535
<211>  129
<212>  PRT
<213>  Homosapiens

<400>  5535

Met Pro Thr Lys Gly Pro Leu Gln Ser Val Gln Val Phe Gly Arg Lys 
1               5                   10                  15      


Lys Thr Ala Thr Ala Val Ala His Cys Lys Arg Gly Asn Gly Leu Ile 
            20                  25                  30          


Lys Leu Leu Glu Pro Val Leu Leu Leu Gly Lys Glu Arg Phe Ala Gly 
        35                  40                  45              


Val Asp Ile Cys Val Arg Met Lys Gly Gly Gly His Val Ala Gln Ile 
    50                  55                  60                  


Tyr Ala Ile His Gln Ser Ile Ser Lys Ala Leu Val Ala Tyr Tyr Gln 
65                  70                  75                  80  


Lys Tyr Val Asp Glu Ala Ser Lys Lys Glu Ile Lys Asp Ile Leu Ile 
                85                  90                  95      


Gln Tyr Asp Gln Thr Leu Leu Val Ala Asp Pro Arg Cys Arg Glu Ser 
            100                 105                 110         


Lys Lys Phe Gly Gly Pro Gly Ala His Ala Arg Tyr Gln Lys Ser Tyr 
        115                 120                 125             


Arg 
    


<210>  5536
<211>  2931
<212>  DNA
<213>  Homosapiens

<400>  5536
ttgaaatgct cgatgatctt ctcttcccgc acgttctcgg gccgggcgtg gcggctcaca     60

cctgtaatct cagcactttg gaaggccctg gcggaaggat ctcttgacgt caggacttcc    120

aaaacagttg ggcaacacag caagaccccg ttcccaggct gggggcaaag ccgggctcgg    180

tggctcacgc ctgtaattcc agcactttgg gaggccgagg tgggcggatc acctgagctc    240

aggagttcga gaccagcctg accaacatgg tgaaacccat ctctactaaa catacaaaaa    300

ttacccgagc gtattggcgg gcgcctgtag tcccagctac atgggaggct gaggcaggag    360

aatcgcttga acccgggagg cgaaggttgc agtgagccga gactgcgcca ctgcactaca    420

gcctggatga caagagactc ccgtctcaaa aaaaaaaaaa aaaagacacc tttctttggg    480

cttagtgagc aaacattcta cgcagtgcct aatataagcc ggcccaggca ccacccaagc    540

cttcggccag gactgttttc ccgtttcgag aaggctccat cacactccac acgggatcca    600

gtcaacagcc gttccaaaca tggcgcggga aggggtggaa gacaagccag cgcgacgccg    660

tccagcctca tccccggggc acaaagggga gactaatctc caggaaactc ggggtacaga    720

atcgataacc ccacaagaaa ctagtttccg cgagtgggcc ttaaggaaaa agtaggtcgg    780

gcacaagcga gctgttcaga cgcacttcac agcaaagact cgcggacaac acagcgagac    840

gaaaacggcc ccgtgcgcag gcgcgcggaa acacgactag cgcgcttcgg gacgacccct    900

cccccttccc tcaaaggcca aggaagtggc tccgacgcgc ttgcgcgagg acggaatgtt    960

gaggggaggg ggaattcttt cccttcattg tcagagagaa ccgcccccgc acggcgagcg   1020

cgcgcgcgct cacgcaccac tctcacactc cggcgcgcca aaggctttcc gcttggcgtc   1080

tcgcgcatgc gcggaggggg aagcagtggc gaaattggat gctttttgct gagtttctca   1140

gagaagtttc tggaaagatg gagccaaagg gacgctgggg ggtggggagc gccaggaagc   1200

aagcgtttga aagaaagcga aaaaacccaa gcgcaccgcg acacctccaa ccttcaagcc   1260

acggcccaag cagagcccaa ggccactgag accctcacgc cagagaaaaa gcacagggac   1320

cgcggcagcc gctcctccct ctgccactgc tcagcccccg agactcccca gcacggggag   1380

agggcagggg gtagccatga gaaacctaga gcgctcactg gacttttgcg aggtggaagg   1440

aaagccgaaa cccgcccttt ggagccgcct gtgcgcacgg gccccgtcga gtgggctcag   1500

tacgttagga ctcagcgtgg ccgccaaagc attggttggg ggcgtctttc actaattttt   1560

cctaggtttt ctcttctatc gggctctgtg gtcctttcac cacccatctt cactttggtg   1620

gcctgacgct aacgctgcga gttggggaaa ccgtagtaac cccgggcctg aggggcgtcc   1680

cgggcggcgg tgctccgttt cttccagcgg ttgccccttt aagaaaaagc cccccggaga   1740

ggggcccgtg tggctgagta aaggtggcgt gcgcccgcac aaaggcgccg cgttgttggc   1800

gggctccgga ccctgttgcc cctgggcggg gcggcgtggg aagaccgggg cgcctgggcg   1860

gggagaacga cgttggcgct agcggggcag ggcaggggga gggagtcacg ggatttagca   1920

ggtgcttctc cgcgaccgag cgactgccat tttgtggtgc ggccgccgcc atttcgcgcg   1980

gccgaggggc ggggtgtggg cggagcggcg ggcgcgcccg ggctgtccct cggggcggcg   2040

ggctaacgcg gccgctttgt tcttcgcttc tcggctcgag gccccagtct cgaccgccga   2100

ccgcctcgga accgggctgc atccgagctg ccacgcggcg tgtgaacctt gaagcgcggc   2160

cggggaatcc gcaaggcgcc gactctcttc ctccttgcaa gcccttcgaa agtgagattt   2220

ctcaccccac ccttgcaggg tggagagaac acgtttcaaa aaggggatgc ctagaactca   2280

gccgtgggaa gtgcctgtct aaagccttgt gctggtgcca gtagcaaacc cgtgcgcgtg   2340

ctcggctttg agcgatcatg gagctctgca aatagctcaa ctgcagagcg tgccccttag   2400

agctcctgtg ctgctgggag gcctcataaa ggtgccaaaa ccaggtgtcc ccagcggttg   2460

gcctctttaa aaagaaaaaa aaaaaaaggc ggagtgggat gtccttgacg tgctgaaaga   2520

cggagtagaa tgagacgttg gttttcattg gctggccatt aagcacgcac tgcgcaactg   2580

ttttccagat acgggtttat agcccattat ttatatcgga gccataaact tgaacaatag   2640

attggaatat cttatttttg cctgttgaga atatctccca tttaacttct tttgaaagtt   2700

cagatgagta tataaataat acattgaccc agtagaatct attgtgtgcg ttccagcgtc   2760

atttcaaaga gctattgttt ttctgatttc aaaagaaata tttaaatgtg agtctttgtg   2820

ttttaatgtt aaccttgtgg ttcgaaatca acaaagccag gaaattcaag agaactgctg   2880

ctaaatttgt cttcttcctt tgctttcgta caaggttttt ttgtttaatt t            2931


<210>  5537
<211>  82
<212>  PRT
<213>  Homosapiens

<400>  5537

Met Ile Phe Ser Ser Arg Thr Phe Ser Gly Arg Ala Trp Arg Leu Thr 
1               5                   10                  15      


Pro Val Ile Ser Ala Leu Trp Lys Ala Leu Ala Glu Gly Ser Leu Asp 
            20                  25                  30          


Val Arg Thr Ser Lys Thr Val Gly Gln His Ser Lys Thr Pro Phe Pro 
        35                  40                  45              


Gly Trp Gly Gln Ser Arg Ala Arg Trp Leu Thr Pro Val Ile Pro Ala 
    50                  55                  60                  


Leu Trp Glu Ala Glu Val Gly Gly Ser Pro Glu Leu Arg Ser Ser Arg 
65                  70                  75                  80  


Pro Ala 
        


<210>  5538
<211>  427
<212>  DNA
<213>  Homosapiens

<400>  5538
acaaatacta tctgtagaca ggtctgttaa atcattcctt tactcagaga cagcaagtcc     60

agcatgggcc tatcgctgga tgattgactc cagagatgac ttcacagagg agcgcctggc    120

caagctgcag gacccattct ctctataccg ctgccacacc atcatgaact gcacaaggac    180

ctgtcctaag ggtctgaatc cagggaaagc tattgcagag atcaagaaaa tgatggcaac    240

ctataaggag aagaaagctt cagtttaact gtttccatgc taaacatgat ttataaccag    300

ctcagagctg aacataattt atatctaatt tgagttcctt taaagatctt ggttttccat    360

gaatacagca tgtataataa aaattttaag aaataaatgt tattctactt tattaacaaa    420

aaaaaaa                                                              427


<210>  5539
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  5539

Met Ile Asp Ser Arg Asp Asp Phe Thr Glu Glu Arg Leu Ala Lys Leu 
1               5                   10                  15      


Gln Asp Pro Phe Ser Leu Tyr Arg Cys His Thr Ile Met Asn Cys Thr 
            20                  25                  30          


Arg Thr Cys Pro Lys Gly Leu Asn Pro Gly Lys Ala Ile Ala Glu Ile 
        35                  40                  45              


Lys Lys Met Met Ala Thr Tyr Lys Glu Lys Lys Ala Ser Val 
    50                  55                  60          


<210>  5540
<211>  1062
<212>  DNA
<213>  Homosapiens

<400>  5540
aaaaaccaac ttctctttct cattttccca caaaaagaga agttacaggt ttgtgtgacc     60

acatgagcaa tattgattcc cagccatgtg aagattggat aatgaagtac actcatactt    120

gtcacttttg ccagctgctc cgagttgggg atgtagaggt cctctaagta acactgctag    180

agcaggccta tggtcatgtg attaactcgt ttcagcctgc tgatctcagg ctgctgagag    240

cgctgtgtaa gttcaaagaa tcattaagtg ggacaaatac tatctgtaga caggtctgtt    300

aaatcattcc tttactcaga gacagcaagt ccagcatggg taggtgccat gaagacagat    360

aagagttata tgatacagtc cctgccttca ccaaattata agctgggtag gaagctattg    420

agcaatgtga aataattagg agatgatacc cagtgtgtat aattaagcac ccgggtacca    480

ggtgcagtat ggatcaaagg tttgcaggga ccattaatca agtgaagcta caagtgttgg    540

gaacctttcc ttgaaagatg gacaagaatt aaagagtatg gagatgaggc atctaagctg    600

agtgaattcc ctttcctctg cactcccaga gctttgagtt gagccagggt gccgctctgg    660

cctgttgatt ggcagctcag ctaatcatcc ctggttttcc aggcctatcg ctggatgatt    720

gactccagag atgacttcac agaggagcgc ctggccaagc tgcaggaccc attctctcta    780

taccgctgcc acaccatcat gaactgcaca aggacctgtc ctaagggtct gaatccaggg    840

aaagctattg cagagatcaa gaaaatgatg gcaacctata aggagaagaa agcttcagtt    900

taactgtttc catgctaaac atgatttata accagctcag agctgaacat aatttatatc    960

taatttgagt tcctttaaag atcttggttt tccatgaata cagcatgtat aataaaaatt   1020

ttaagaaata aatgttattc tactttatta acaaaaaaaa aa                      1062


<210>  5541
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  5541

Met Ile Asp Ser Arg Asp Asp Phe Thr Glu Glu Arg Leu Ala Lys Leu 
1               5                   10                  15      


Gln Asp Pro Phe Ser Leu Tyr Arg Cys His Thr Ile Met Asn Cys Thr 
            20                  25                  30          


Arg Thr Cys Pro Lys Gly Leu Asn Pro Gly Lys Ala Ile Ala Glu Ile 
        35                  40                  45              


Lys Lys Met Met Ala Thr Tyr Lys Glu Lys Lys Ala Ser Val 
    50                  55                  60          


<210>  5542
<211>  1168
<212>  DNA
<213>  Homosapiens

<400>  5542
gccttccctc cgcccacccg ggaaaccgga agccgcctcc cacttggttg ctcgtacgcg     60

gctagtgggt cctcagtgga tgtaggctgg gcgccgcgat gttcgacggg acaccggcgg    120

agagcgacct cggggttaag gggtggggct gacgtcagga gccaagatgg cggcggtggt    180

cgccctctcc ttgaggcgcc ggttgccggc cacaaccctt ggcggagcct gcctgcaggc    240

ctcccgagga gcccagacag ctgcagccac agctccccgt atcaagaaat ttgccatcta    300

tcgatgggac ccagacaagg ctggagacaa acctcatatg cagacttatg aagttgacct    360

taataaatgt ggccccatgg tattggatgc tttaatcaag attaagaatg aagttgactc    420

tactttgacc ttccgaagat catgcagaga aggcatctgt ggctcttgtg caatgaacat    480

caatggaggc aacactctag cttgcacccg aaggattgac accaacctca ataaggtctc    540

aaaaatctac cctcttccac acatgtatgt gataaaggat cttgttcccg atttgagcaa    600

cttctatgca cagtacaaat ccattgagcc ttatttgaag aagaaggatg aatctcagga    660

aggcaagcag cagtatctgc agtccataga agagcgtgag aaactggacg ggctctacga    720

gtgcattctc tgtgcctgct gtagcaccag ctgccccagc tactggtgga acggagacaa    780

atatctgggg cctgcagttc ttatgcaggc ctatcgctgg atgattgact ccagagatga    840

cttcacagag gagcgcctgg ccaagctgca ggacccattc tctctatacc gctgccacac    900

catcatgaac tgcacaagga cctgtcctaa gggtctgaat ccagggaaag ctattgcaga    960

gatcaagaaa atgatggcaa cctataagga gaagaaagct tcagtttaac tgtttccatg   1020

ctaaacatga tttataacca gctcagagct gaacataatt tatatctaat ttgagttcct   1080

ttaaagatct tggttttcca tgaatacagc atgtataata aaaattttaa gaaataaatg   1140

ttattctact ttattaacaa aaaaaaaa                                      1168


<210>  5543
<211>  280
<212>  PRT
<213>  Homosapiens

<400>  5543

Met Ala Ala Val Val Ala Leu Ser Leu Arg Arg Arg Leu Pro Ala Thr 
1               5                   10                  15      


Thr Leu Gly Gly Ala Cys Leu Gln Ala Ser Arg Gly Ala Gln Thr Ala 
            20                  25                  30          


Ala Ala Thr Ala Pro Arg Ile Lys Lys Phe Ala Ile Tyr Arg Trp Asp 
        35                  40                  45              


Pro Asp Lys Ala Gly Asp Lys Pro His Met Gln Thr Tyr Glu Val Asp 
    50                  55                  60                  


Leu Asn Lys Cys Gly Pro Met Val Leu Asp Ala Leu Ile Lys Ile Lys 
65                  70                  75                  80  


Asn Glu Val Asp Ser Thr Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly 
                85                  90                  95      


Ile Cys Gly Ser Cys Ala Met Asn Ile Asn Gly Gly Asn Thr Leu Ala 
            100                 105                 110         


Cys Thr Arg Arg Ile Asp Thr Asn Leu Asn Lys Val Ser Lys Ile Tyr 
        115                 120                 125             


Pro Leu Pro His Met Tyr Val Ile Lys Asp Leu Val Pro Asp Leu Ser 
    130                 135                 140                 


Asn Phe Tyr Ala Gln Tyr Lys Ser Ile Glu Pro Tyr Leu Lys Lys Lys 
145                 150                 155                 160 


Asp Glu Ser Gln Glu Gly Lys Gln Gln Tyr Leu Gln Ser Ile Glu Glu 
                165                 170                 175     


Arg Glu Lys Leu Asp Gly Leu Tyr Glu Cys Ile Leu Cys Ala Cys Cys 
            180                 185                 190         


Ser Thr Ser Cys Pro Ser Tyr Trp Trp Asn Gly Asp Lys Tyr Leu Gly 
        195                 200                 205             


Pro Ala Val Leu Met Gln Ala Tyr Arg Trp Met Ile Asp Ser Arg Asp 
    210                 215                 220                 


Asp Phe Thr Glu Glu Arg Leu Ala Lys Leu Gln Asp Pro Phe Ser Leu 
225                 230                 235                 240 


Tyr Arg Cys His Thr Ile Met Asn Cys Thr Arg Thr Cys Pro Lys Gly 
                245                 250                 255     


Leu Asn Pro Gly Lys Ala Ile Ala Glu Ile Lys Lys Met Met Ala Thr 
            260                 265                 270         


Tyr Lys Glu Lys Lys Ala Ser Val 
        275                 280 


<210>  5544
<211>  921
<212>  DNA
<213>  Homosapiens

<400>  5544
gtacgcggct agtgggtcct cagtggatgt aggctgggcg ccgcgatgtt cgacgggaca     60

ccggcggaga gcgacctcgg ggttaagggg tggggctgac gtcaggagcc aagatggcgg    120

cggtggtcgc cctctccttg aggcgccggt tgccggccac aacccttggc ggagcctgcc    180

tgcaggcctc ccgaggagcc cagacagctg cagccacagc tccccgtatc aagaaatttg    240

ccatctatcg atgggaccca gacaaggctg gagacaaacc tcatatgcag acttatgaag    300

ttgaccttaa taaatgtggc cccatggtat tggatgcttt aatcaagatt aagaatgaag    360

ttgactctac tttgaccttc cgaagatcat gcagagaagg tgagcatttc attcctgttg    420

ggctccagat acttgtggtc ttccaaagag gcttgggctg gccaaagctg atagagacat    480

ctggaaaaca gctgcagctc tctgctgggt gaacttgctg tgcaacctaa ttccttttct    540

tgggtaaatg catccaaaat tctaaccatg gtgcaagttc tggtttctga gtttactttc    600

cttcaggagc attctatcct gtggttactg catctggcgg tccctgtgag ctgctccacg    660

cttcaaggcc tagctaggac ctgctggctg gcaccttcca tgctgctgag ctcttttatt    720

aagggagcag tggagagttt ctgtctggca cttatgcttg tccagcaggg gagatgtgtg    780

agtctccctc agctcccagc atgacatgtc cttggtagct gtgttctgga ttggctggta    840

cagtgtctcc ctcagcatgt ggttacttgt gctgctggtg ccacatgagc ccatttgagg    900

cagtgtgcag actaacattt t                                              921


<210>  5545
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  5545

Met Ala Ala Val Val Ala Leu Ser Leu Arg Arg Arg Leu Pro Ala Thr 
1               5                   10                  15      


Thr Leu Gly Gly Ala Cys Leu Gln Ala Ser Arg Gly Ala Gln Thr Ala 
            20                  25                  30          


Ala Ala Thr Ala Pro Arg Ile Lys Lys Phe Ala Ile Tyr Arg Trp Asp 
        35                  40                  45              


Pro Asp Lys Ala Gly Asp Lys Pro His Met Gln Thr Tyr Glu Val Asp 
    50                  55                  60                  


Leu Asn Lys Cys Gly Pro Met Val Leu Asp Ala Leu Ile Lys Ile Lys 
65                  70                  75                  80  


Asn Glu Val Asp Ser Thr Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly 
                85                  90                  95      


Glu His Phe Ile Pro Val Gly Leu Gln Ile Leu Val Val Phe Gln Arg 
            100                 105                 110         


Gly Leu Gly Trp Pro Lys Leu Ile Glu Thr Ser Gly Lys Gln Leu Gln 
        115                 120                 125             


Leu Ser Ala Gly 
    130         


<210>  5546
<211>  4638
<212>  DNA
<213>  Homosapiens

<400>  5546
aggatgtgct tcaagttaag ttgttactca acggaaaaca tattcaggat gctgcttgct     60

atttgtgtgt tttgttttgt ttgagacgag gtctcgctct gtcacccagg ctggagtgca    120

gtggcatgat ctcagctcac tgcaacctcc gccttgcggg cttaagcaat cctcccacct    180

cagcctccca acactttggg aggctgaggt gggaggattg cctgagaaca ggaattcaag    240

acatgcttgg gcaacatagc aagaccctga ctccacaaaa aaaaatttaa aaattagcct    300

ggcatggtag tgcacacctg tagtcgtagc tactcagagg ctgaggcagg aggaccgctt    360

gagcccagga gtttgaggct gcagtgggcc ataatcatgg cactgcactc cagcctgggc    420

aacagagtga gaccctgtct caaaaaaaaa aaaatggggc tgatatcggt aagaaacctg    480

cctgtgatgt gcagagactg cctatggaca cctgtgctgc catcatcagt gtgaggggag    540

gaggatgggg gaccagggaa tggggaacaa gacagacgtt cttcttcctt tgtgctcttg    600

tgtttctcga gttttctgcc catgtgcaca aattgtcccc tggattcgtc taacagttct    660

ccttggtgtc cctgcaggat gaaattgagt ttggctacat cgaggccccc cataaaggct    720

tccccgtggt gctggactct ccccgagatg gaaacctaaa ggacttccct gtgaaggagc    780

tcctgggccc agattttggc tacgtgaccc gggagcccct ctttgagtct gtcaccagcc    840

ttgactcatt tggaaacctg gaggtcagtc ccccagtgac cgtgaacggc aagacatacc    900

cgcttggccg catcctcatc gggagcagct ttcctctgtc tggtggtcgg aggatgacca    960

aggtggtgcg tgacttcctg aaggcccagc aggtgcaggc gcccgtggag ctctactcag   1020

actggctgac tgtgggccac gtggatgagt tcatgtcctt tgtccccatc cccggcacaa   1080

aggtaagcta gcctcccgag gctggagtga atggggtagc agcaaaccaa tatattaccc   1140

gcccctgcca gcagagggca agagctagag gaactcgaca gcataaagga aggaggaagt   1200

aggctgaagc tggtttgcat gttgttgctg tggcaggtaa aattttaacc ccataaatcc   1260

aaaatgttag cattgcaaca cataatcagc ctaaaaatta ttaacgagag atttaaattc   1320

ttttctcata ctaaatcttc aaaatctggc aaagatttta ctcacatgac acacctaaat   1380

tcagactagc cacagctcaa gtgttcaata gtcacataag gctagtggct attgtgttgg   1440

tggtaatgct ctagagagaa ataggttatg cacctgtggc actggaaaga ggttctttca   1500

ttttcttatg ggtacaactt cataccctgg aaattctctg caaattgtgt ggctgcttgg   1560

caacttggag atgtcctgtc caagtccacc tttgactctg agccttgatc tggtgacatt   1620

gctgaggtag aggaaaggtg agaaatattc ctctgaagca gagaacaccc tccccgtcag   1680

cctttgccac tcggcatggg aggcctgagg caatgagcag gcaaggcact gggtcctcag   1740

cgcagggcct ccccgtgctc cttgggtgcc ttcccactgc tgactctgtc cctctggact   1800

gtctcttgca gaaattcctg ctactcatgg ccagcacctc ggcctgctac aagctcttcc   1860

gagagaagca gaaggacggc catggagagg ccatcatgtt caaaggcttg ggtgggatga   1920

gcagcaagcg aatcaccatc aacaagattc tgtccaacga gagccttgtg caggagaacc   1980

tgtacttcca gcgctgccta gactggaacc gtgacatcct caagaaggag ctgggactga   2040

cagagcagga catcattgac ctgcccgctc tgttcaagat ggacgaggac caccgtgcca   2100

gagccttctt cccaaacatg gtgaacatga tcgtgctgga caaggacctg ggcatcccca   2160

agccattcgg gccacaggtt gaggaggaat gctgcctgga gatgcacgtg cgtggcctcc   2220

tggagcccct gggcctcgaa tgcaccttca tcgacgacat ttctgcctac cacaaatttc   2280

tgggggaagt ccactgtggc accaacgtcc gcaggaagcc cttcaccttc aagtggtggc   2340

acatggtgcc ctgacctgcc aggggccctg gcgtttgcct ccttcgctta gttctccaga   2400

ccctccctca cacgcccaga gccttctgct gacatggact ggacagcccc gctgggagac   2460

ctttgggacg tggggtggaa tttggggtat ctgtgccttg ccctccctga gaggggcctc   2520

agtgtcctct gaagccatcc ccagtgagcc tcgactctgt ccctgctgaa aatagctggg   2580

ccagtgtctc tgtagccctg acataaggaa cagaacacaa caaaacacag caaaccatgt   2640

gcccaaactg ctccccaaag aattttgagt ctctaatctg acactgaatg aggggagaag   2700

ggaaggagat tctgggattg ccagttcttc cagcagccat gctctgaaaa tcaaggtaga   2760

atccatggaa agggacccca ggaccccggg accctagacg tatcttgaac tgccatcgtc   2820

atttcaaata catctccctc agggtttcca ggtggccacc cccaattatt cattccttac   2880

caacctctca aatcctcttg gctttctctc tgcagtgtgg acactgttgg ctagtcctcc   2940

ccactccctg agggtccagt aagttagctt agaaccttcc tggaaacatt tcatctgagc   3000

aggtttcccc acgtgtggga tgctcctttt gcctcatctg tctcagggat gcaggctccc   3060

ccgcatgcat ggggatttct ccccagacca gcatacttgt gacctgagag ttcaatgcgt   3120

aaagatgccc ctggtcagcc atatccatct tctcttgcct ggtccttgat tctctggccg   3180

ctccctgacc ttcctccttc cactgccttg actttcttcc tttttattcc tggtgccatc   3240

tgtccaggca gctagacaag aacttgttcg ccagcagcca gattcaggcc ttcccagggg   3300

cataataagt gaccagcccc tcctctccgg acatcagatc caacacataa ggaccctggc   3360

ctaccctcca gcccaacagc cagttctggg tcagctgcca acttaggggt ggtttgatta   3420

tcccattgaa attcaccagt gcctttgcca aagaccctct catttggaca tacccagatt   3480

cattccctgg ctccaactga aaagactcag tttcaatcgt taaaagttcc tttagggcca   3540

gaagaataaa tgaattataa tcccattttg aagaaccgat ttataaccaa tgaaaaggtt   3600

ataatgtaat ttatattctt ggaggaacaa gattttcatt tgggattatt tccttcaacc   3660

attcaacaaa catttgttgt atgccactaa gcgccaggca cggcgttggg ctctgcaaac   3720

acagtggtta gtagcagtct ggacctggtc cctactggca tggaacccat cactccccaa   3780

catgcaaagc ccacatttaa aggccagcct ctgccccttc agtgatgcgc tctttagaaa   3840

tgccagtcca ctatattcag aaatccgcag ggcacaaaac ttccagcaag tcactgttgt   3900

ggtgaaatgg gcagtggggg tggggggtct tctttaaaca ggcccccttc ccatctacct   3960

agccagtacc catccaatga gtccccagag cctccagaag ctgttgtctc ctctctgggg   4020

acagcagctc ctgcctttgg aggccaaagc cccagatctc tccagcccca gagctgaaaa   4080

caccaagtgc ctatttgagg gtgtctgtct ggagacttag agtttgtcat gtgtgtgtgt   4140

gtgtttggtt aatgtgggtt tatgggtttt ctttcttttt tttctttttt tttttagtct   4200

acattagggg gaagtgagcg cctcccatgt gcagacagtg tgtctttata gatttttcta   4260

aggctttccc caatgatgtc ggtaatttct gatgtttctg aagttcccag gactcacaca   4320

cccgttccca tctcacttgc ccacccagtg tgacaaccct cggtgtggat atacccccgt   4380

ggactcatgg ctcttcccca cccccacttt ctataaatgt aggcctagaa tacgcttctc   4440

tgttgcaaaa ctcagctaag ttcctgcttc caccttgatg ttgaaatatc ttatgtaaga   4500

gggcagggga tgtcgtgaag atggcaagaa gaacacagtt tcaaatttct ggaaaagagc   4560

ctgtggtgga gatctaaaga tgtttaggga agagctcgac taaagaacaa tgaaataaat   4620

ggtccaaggg gaagtcat                                                 4638


<210>  5547
<211>  213
<212>  PRT
<213>  Homosapiens

<400>  5547

Met Ser Arg Gln Gly Thr Gly Ser Ser Ala Gln Gly Leu Pro Val Leu 
1               5                   10                  15      


Leu Gly Cys Leu Pro Thr Ala Asp Ser Val Pro Leu Asp Cys Leu Leu 
            20                  25                  30          


Gln Lys Phe Leu Leu Leu Met Ala Ser Thr Ser Ala Cys Tyr Lys Leu 
        35                  40                  45              


Phe Arg Glu Lys Gln Lys Asp Gly His Gly Glu Ala Ile Met Phe Lys 
    50                  55                  60                  


Gly Leu Gly Gly Met Ser Ser Lys Arg Ile Thr Ile Asn Lys Ile Leu 
65                  70                  75                  80  


Ser Asn Glu Ser Leu Val Gln Glu Asn Leu Tyr Phe Gln Arg Cys Leu 
                85                  90                  95      


Asp Trp Asn Arg Asp Ile Leu Lys Lys Glu Leu Gly Leu Thr Glu Gln 
            100                 105                 110         


Asp Ile Ile Asp Leu Pro Ala Leu Phe Lys Met Asp Glu Asp His Arg 
        115                 120                 125             


Ala Arg Ala Phe Phe Pro Asn Met Val Asn Met Ile Val Leu Asp Lys 
    130                 135                 140                 


Asp Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Val Glu Glu Glu Cys 
145                 150                 155                 160 


Cys Leu Glu Met His Val Arg Gly Leu Leu Glu Pro Leu Gly Leu Glu 
                165                 170                 175     


Cys Thr Phe Ile Asp Asp Ile Ser Ala Tyr His Lys Phe Leu Gly Glu 
            180                 185                 190         


Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Thr Phe Lys Trp 
        195                 200                 205             


Trp His Met Val Pro 
    210             


<210>  5548
<211>  4352
<212>  DNA
<213>  Homosapiens

<400>  5548
agaaggcgca cctgctgcag gtgctcccgg ccgccccgga ccagcgagcg cgggcactgc     60

ggcggggagg atgctgcgcg agcggaccgt gcggctgcag tacgggagcc gcgtggaggc    120

ggtgtacgtg ctgggcacct acctctggac cgatgtctac agcgcggccc cagccggggc    180

ccaaaccttc agcctgaagc actcggaaca cgtgtgggtg gaggtggtgc gtgatgggga    240

ggctgaggag gtggccacca atggcaagca gcgctggctt ctctcgccca gcaccaccct    300

gcgggtcacc atgagccagg cgagcaccga ggccagcagt gacaaggtca ccgtcaacta    360

ctatgacgag gaagggagca ttcccatcga ccaggcgggg ctcttcctca cagccattga    420

gatctccctg gatgtggacg cagaccggga tggtgtggtg gagaagaaca acccaaagaa    480

ggcatcctgg acctggggcc ccgagggcca gggggccatc ctgctggtga actgtgaccg    540

agagacaccc tggttgccca aggaggactg ccgtgatgag aaggtctaca gcaaggaaga    600

tctcaaggac atgtcccaga tgatcctgcg gaccaaaggc cccgaccgcc tccccgccgg    660

atacgagata gttctgtaca tttccatgtc agactcagac aaagtgggcg tgttctacgt    720

ggagaacccg ttcttcggcc aacgctatat ccacatcctg ggccggcgga agctctacca    780

tgtggtcaag tacacgggtg gctccgcgga gctgctgttc ttcgtggaag gcctctgttt    840

ccccgacgag ggcttctcag gcctggtctc catccatgtc agcctgctgg agtacatggc    900

ccaggacatt cccctgactc ccatcttcac ggacaccgtg atattccgga ttgctccgtg    960

gatcatgacc cccaacatcc tgcctcccgt gtcggtgttt gtgtgctgca tgaaggataa   1020

ttacctgttc ctgaaagagg tgaagaacct tgtggagaaa accaactgtg agctgaaggt   1080

ctgcttccag tacctaaacc gaggcgatcg ctggatccag gatgaaattg agtttggcta   1140

catcgaggcc ccccataaag gcttccccgt ggtgctggac tctccccgag atggaaacct   1200

aaaggacttc cctgtgaagg agctcctggg cccagatttt ggctacgtga cccgggagcc   1260

cctctttgag tctgtcacca gccttgactc atttggaaac ctggaggtca gtcccccagt   1320

gaccgtgaac ggcaagacat acccgcttgg ccgcatcctc atcgggagca gctttcctct   1380

gtctggtggt cggaggatga ccaaggtggt gcgtgacttc ctgaaggccc agcaggtgca   1440

ggcgcccgtg gagctctact cagactggct gactgtgggc cacgtggatg agttcatgtc   1500

ctttgtcccc atccccggca caaagaaatt cctgctactc atggccagca cctcggcctg   1560

ctacaagctc ttccgagaga agcagaagga cggccatgga gaggccatca tgttcaaagg   1620

cttgggtggg atgagcagca agcgaatcac catcaacaag attctgtcca acgagagcct   1680

tgtgcaggag aacctgtact tccagcgctg cctagactgg aaccgtgaca tcctcaagaa   1740

ggagctggga ctgacagagc aggacatcat tgacctgccc gctctgttca agatggacga   1800

ggaccaccgt gccagagcct tcttcccaaa catggtgaac atgatcgtgc tggacaagga   1860

cctgggcatc cccaagccat tcgggccaca ggttgaggag gaatgctgcc tggagatgca   1920

cgtgcgtggc ctcctggagc ccctgggcct cgaatgcacc ttcatcgacg acatttctgc   1980

ctaccacaaa tttctggggg aagtccactg tggcaccaac gtccgcagga agcccttcac   2040

cttcaagtgg tggcacatgg tgccctgacc tgccaggggc cctggcgttt gcctccttcg   2100

cttagttctc cagaccctcc ctcacacgcc cagagccttc tgctgacatg gactggacag   2160

ccccgctggg agacctttgg gacgtggggt ggaatttggg gtatctgtgc cttgccctcc   2220

ctgagagggg cctcagtgtc ctctgaagcc atccccagtg agcctcgact ctgtccctgc   2280

tgaaaatagc tgggccagtg tctctgtagc cctgacataa ggaacagaac acaacaaaac   2340

acagcaaacc atgtgcccaa actgctcccc aaagaatttt gagtctctaa tctgacactg   2400

aatgagggga gaagggaagg agattctggg attgccagtt cttccagcag ccatgctctg   2460

aaaatcaagg tagaatccat ggaaagggac cccaggaccc cgggacccta gacgtatctt   2520

gaactgccat cgtcatttca aatacatctc cctcagggtt tccaggtggc cacccccaat   2580

tattcattcc ttaccaacct ctcaaatcct cttggctttc tctctgcagt gtggacactg   2640

ttggctagtc ctccccactc cctgagggtc cagtaagtta gcttagaacc ttcctggaaa   2700

catttcatct gagcaggttt ccccacgtgt gggatgctcc ttttgcctca tctgtctcag   2760

ggatgcaggc tcccccgcat gcatggggat ttctccccag accagcatac ttgtgacctg   2820

agagttcaat gcgtaaagat gcccctggtc agccatatcc atcttctctt gcctggtcct   2880

tgattctctg gccgctccct gaccttcctc cttccactgc cttgactttc ttccttttta   2940

ttcctggtgc catctgtcca ggcagctaga caagaacttg ttcgccagca gccagattca   3000

ggccttccca ggggcataat aagtgaccag cccctcctct ccggacatca gatccaacac   3060

ataaggaccc tggcctaccc tccagcccaa cagccagttc tgggtcagct gccaacttag   3120

gggtggtttg attatcccat tgaaattcac cagtgccttt gccaaagacc ctctcatttg   3180

gacataccca gattcattcc ctggctccaa ctgaaaagac tcagtttcaa tcgttaaaag   3240

ttcctttagg gccagaagaa taaatgaatt ataatcccat tttgaagaac cgatttataa   3300

ccaatgaaaa ggttataatg taatttatat tcttggagga acaagatttt catttgggat   3360

tatttccttc aaccattcaa caaacatttg ttgtatgcca ctaagcgcca ggcacggcgt   3420

tgggctctgc aaacacagtg gttagtagca gtctggacct ggtccctact ggcatggaac   3480

ccatcactcc ccaacatgca aagcccacat ttaaaggcca gcctctgccc cttcagtgat   3540

gcgctcttta gaaatgccag tccactatat tcagaaatcc gcagggcaca aaacttccag   3600

caagtcactg ttgtggtgaa atgggcagtg ggggtggggg gtcttcttta aacaggcccc   3660

cttcccatct acctagccag tacccatcca atgagtcccc agagcctcca gaagctgttg   3720

tctcctctct ggggacagca gctcctgcct ttggaggcca aagccccaga tctctccagc   3780

cccagagctg aaaacaccaa gtgcctattt gagggtgtct gtctggagac ttagagtttg   3840

tcatgtgtgt gtgtgtgttt ggttaatgtg ggtttatggg ttttctttct tttttttctt   3900

ttttttttta gtctacatta gggggaagtg agcgcctccc atgtgcagac agtgtgtctt   3960

tatagatttt tctaaggctt tccccaatga tgtcggtaat ttctgatgtt tctgaagttc   4020

ccaggactca cacacccgtt cccatctcac ttgcccaccc agtgtgacaa ccctcggtgt   4080

ggatataccc ccgtggactc atggctcttc cccaccccca ctttctataa atgtaggcct   4140

agaatacgct tctctgttgc aaaactcagc taagttcctg cttccacctt gatgttgaaa   4200

tatcttatgt aagagggcag gggatgtcgt gaagatggca agaagaacac agtttcaaat   4260

ttctggaaaa gagcctgtgg tggagatcta aagatgttta gggaagagct cgactaaaga   4320

acaatgaaat aaatggtcca aggggaagtc at                                 4352


<210>  5549
<211>  665
<212>  PRT
<213>  Homosapiens

<400>  5549

Met Leu Arg Glu Arg Thr Val Arg Leu Gln Tyr Gly Ser Arg Val Glu 
1               5                   10                  15      


Ala Val Tyr Val Leu Gly Thr Tyr Leu Trp Thr Asp Val Tyr Ser Ala 
            20                  25                  30          


Ala Pro Ala Gly Ala Gln Thr Phe Ser Leu Lys His Ser Glu His Val 
        35                  40                  45              


Trp Val Glu Val Val Arg Asp Gly Glu Ala Glu Glu Val Ala Thr Asn 
    50                  55                  60                  


Gly Lys Gln Arg Trp Leu Leu Ser Pro Ser Thr Thr Leu Arg Val Thr 
65                  70                  75                  80  


Met Ser Gln Ala Ser Thr Glu Ala Ser Ser Asp Lys Val Thr Val Asn 
                85                  90                  95      


Tyr Tyr Asp Glu Glu Gly Ser Ile Pro Ile Asp Gln Ala Gly Leu Phe 
            100                 105                 110         


Leu Thr Ala Ile Glu Ile Ser Leu Asp Val Asp Ala Asp Arg Asp Gly 
        115                 120                 125             


Val Val Glu Lys Asn Asn Pro Lys Lys Ala Ser Trp Thr Trp Gly Pro 
    130                 135                 140                 


Glu Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Glu Thr Pro 
145                 150                 155                 160 


Trp Leu Pro Lys Glu Asp Cys Arg Asp Glu Lys Val Tyr Ser Lys Glu 
                165                 170                 175     


Asp Leu Lys Asp Met Ser Gln Met Ile Leu Arg Thr Lys Gly Pro Asp 
            180                 185                 190         


Arg Leu Pro Ala Gly Tyr Glu Ile Val Leu Tyr Ile Ser Met Ser Asp 
        195                 200                 205             


Ser Asp Lys Val Gly Val Phe Tyr Val Glu Asn Pro Phe Phe Gly Gln 
    210                 215                 220                 


Arg Tyr Ile His Ile Leu Gly Arg Arg Lys Leu Tyr His Val Val Lys 
225                 230                 235                 240 


Tyr Thr Gly Gly Ser Ala Glu Leu Leu Phe Phe Val Glu Gly Leu Cys 
                245                 250                 255     


Phe Pro Asp Glu Gly Phe Ser Gly Leu Val Ser Ile His Val Ser Leu 
            260                 265                 270         


Leu Glu Tyr Met Ala Gln Asp Ile Pro Leu Thr Pro Ile Phe Thr Asp 
        275                 280                 285             


Thr Val Ile Phe Arg Ile Ala Pro Trp Ile Met Thr Pro Asn Ile Leu 
    290                 295                 300                 


Pro Pro Val Ser Val Phe Val Cys Cys Met Lys Asp Asn Tyr Leu Phe 
305                 310                 315                 320 


Leu Lys Glu Val Lys Asn Leu Val Glu Lys Thr Asn Cys Glu Leu Lys 
                325                 330                 335     


Val Cys Phe Gln Tyr Leu Asn Arg Gly Asp Arg Trp Ile Gln Asp Glu 
            340                 345                 350         


Ile Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Gly Phe Pro Val Val 
        355                 360                 365             


Leu Asp Ser Pro Arg Asp Gly Asn Leu Lys Asp Phe Pro Val Lys Glu 
    370                 375                 380                 


Leu Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Leu Phe Glu 
385                 390                 395                 400 


Ser Val Thr Ser Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro 
                405                 410                 415     


Val Thr Val Asn Gly Lys Thr Tyr Pro Leu Gly Arg Ile Leu Ile Gly 
            420                 425                 430         


Ser Ser Phe Pro Leu Ser Gly Gly Arg Arg Met Thr Lys Val Val Arg 
        435                 440                 445             


Asp Phe Leu Lys Ala Gln Gln Val Gln Ala Pro Val Glu Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Thr Val Gly His Val Asp Glu Phe Met Ser Phe Val Pro 
465                 470                 475                 480 


Ile Pro Gly Thr Lys Lys Phe Leu Leu Leu Met Ala Ser Thr Ser Ala 
                485                 490                 495     


Cys Tyr Lys Leu Phe Arg Glu Lys Gln Lys Asp Gly His Gly Glu Ala 
            500                 505                 510         


Ile Met Phe Lys Gly Leu Gly Gly Met Ser Ser Lys Arg Ile Thr Ile 
        515                 520                 525             


Asn Lys Ile Leu Ser Asn Glu Ser Leu Val Gln Glu Asn Leu Tyr Phe 
    530                 535                 540                 


Gln Arg Cys Leu Asp Trp Asn Arg Asp Ile Leu Lys Lys Glu Leu Gly 
545                 550                 555                 560 


Leu Thr Glu Gln Asp Ile Ile Asp Leu Pro Ala Leu Phe Lys Met Asp 
                565                 570                 575     


Glu Asp His Arg Ala Arg Ala Phe Phe Pro Asn Met Val Asn Met Ile 
            580                 585                 590         


Val Leu Asp Lys Asp Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Val 
        595                 600                 605             


Glu Glu Glu Cys Cys Leu Glu Met His Val Arg Gly Leu Leu Glu Pro 
    610                 615                 620                 


Leu Gly Leu Glu Cys Thr Phe Ile Asp Asp Ile Ser Ala Tyr His Lys 
625                 630                 635                 640 


Phe Leu Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe 
                645                 650                 655     


Thr Phe Lys Trp Trp His Met Val Pro 
            660                 665 


<210>  5550
<211>  1613
<212>  DNA
<213>  Homosapiens

<400>  5550
agaaggcgca cctgctgcag gtgctcccgg ccgccccgga ccagcgagcg cgggcactgc     60

ggcggggagg atgctgcgcg agcggaccgt gcggctgcag tacgggagcc gcgtggaggc    120

ggtgtacgtg ctgggcacct acctctggac cgatgtctac agcgcggccc cagccggggc    180

ccaaaccttc agcctgaagc actcggaaca cgtgtgggtg gaggtggtgc gtgatgggga    240

ggctgaggag gtggccacca atggcaagca gcgctggctt ctctcgccca gcaccaccct    300

gcgggtcacc atgagccagg cgagcaccga ggccagcagt gacaaggtca ccgtcaacta    360

ctatgacgag gaagggagca ttcccatcga ccaggcgggg ctcttcctca cagccattga    420

gatctccctg gatgtggacg cagaccggga tggtgtggtg gagaagaaca acccaaagaa    480

ggcatcctgg acctggggcc ccgagggcca gggggccatc ctgctggtga actgtgaccg    540

agagacaccc tggttgccca aggaggactg ccgtgatgag aaggtctaca gcaaggaaga    600

tctcaaggac atgtcccaga tgatcctgcg gaccaaaggc cccgaccgcc tccccgccgg    660

atacgagata gttctgtaca tttccatgtc agactcagac aaagtgggcg tgttctacgt    720

ggagaacccg ttcttcggcc aacgctatat ccacatcctg ggccggcgga agctctacca    780

tgtggtcaag tacacgggtg gctccgcgga gctgctgttc ttcgtggaag gcctctgttt    840

ccccgacgag ggcttctcag gcctggtctc catccatgtc agcctgctgg agtacatggc    900

ccaggacatt cccctgactc ccatcttcac ggacaccgtg atattccgga ttgctccgtg    960

gatcatgacc cccaacatcc tgcctcccgt gtcggtgttt gtgtgctgca tgaaggataa   1020

ttacctgttc ctgaaagagg tgaagaacct tgtggagaaa accaactgtg agctgaaggt   1080

ctgcttccag tacctaaacc gaggcgatcg ctggatccag gatgaaattg agtttggcta   1140

catcgaggcc ccccataaag gcttccccgt ggtgctggac tctccccgag atggaaacct   1200

aaaggacttc cctgtgaagg agctcctggg cccagatttt ggctacgtga cccgggagcc   1260

cctctttgag tctgtcacca gccttgactc atttggaaac ctggaggtca gtcccccagt   1320

gaccgtgaac ggcaagacat acccgcttgg ccgcatcctc atcgggagca gctttcctct   1380

gtaagagaag ccaggctggg gctaggggct gtgggagtgg ggaagtcact gtttctcttt   1440

tggggtggcc tgggttgctc acacatggag caagtggctg ggggaattat tccctcccac   1500

gacttcctgt taagaggccg acactcttgg aaagaaaatc aagctagcct ttatatcttt   1560

gtgtgattta ggatctaata tataactaaa taaacaactc ttttccccaa gtg          1613


<210>  5551
<211>  437
<212>  PRT
<213>  Homosapiens

<400>  5551

Met Leu Arg Glu Arg Thr Val Arg Leu Gln Tyr Gly Ser Arg Val Glu 
1               5                   10                  15      


Ala Val Tyr Val Leu Gly Thr Tyr Leu Trp Thr Asp Val Tyr Ser Ala 
            20                  25                  30          


Ala Pro Ala Gly Ala Gln Thr Phe Ser Leu Lys His Ser Glu His Val 
        35                  40                  45              


Trp Val Glu Val Val Arg Asp Gly Glu Ala Glu Glu Val Ala Thr Asn 
    50                  55                  60                  


Gly Lys Gln Arg Trp Leu Leu Ser Pro Ser Thr Thr Leu Arg Val Thr 
65                  70                  75                  80  


Met Ser Gln Ala Ser Thr Glu Ala Ser Ser Asp Lys Val Thr Val Asn 
                85                  90                  95      


Tyr Tyr Asp Glu Glu Gly Ser Ile Pro Ile Asp Gln Ala Gly Leu Phe 
            100                 105                 110         


Leu Thr Ala Ile Glu Ile Ser Leu Asp Val Asp Ala Asp Arg Asp Gly 
        115                 120                 125             


Val Val Glu Lys Asn Asn Pro Lys Lys Ala Ser Trp Thr Trp Gly Pro 
    130                 135                 140                 


Glu Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Glu Thr Pro 
145                 150                 155                 160 


Trp Leu Pro Lys Glu Asp Cys Arg Asp Glu Lys Val Tyr Ser Lys Glu 
                165                 170                 175     


Asp Leu Lys Asp Met Ser Gln Met Ile Leu Arg Thr Lys Gly Pro Asp 
            180                 185                 190         


Arg Leu Pro Ala Gly Tyr Glu Ile Val Leu Tyr Ile Ser Met Ser Asp 
        195                 200                 205             


Ser Asp Lys Val Gly Val Phe Tyr Val Glu Asn Pro Phe Phe Gly Gln 
    210                 215                 220                 


Arg Tyr Ile His Ile Leu Gly Arg Arg Lys Leu Tyr His Val Val Lys 
225                 230                 235                 240 


Tyr Thr Gly Gly Ser Ala Glu Leu Leu Phe Phe Val Glu Gly Leu Cys 
                245                 250                 255     


Phe Pro Asp Glu Gly Phe Ser Gly Leu Val Ser Ile His Val Ser Leu 
            260                 265                 270         


Leu Glu Tyr Met Ala Gln Asp Ile Pro Leu Thr Pro Ile Phe Thr Asp 
        275                 280                 285             


Thr Val Ile Phe Arg Ile Ala Pro Trp Ile Met Thr Pro Asn Ile Leu 
    290                 295                 300                 


Pro Pro Val Ser Val Phe Val Cys Cys Met Lys Asp Asn Tyr Leu Phe 
305                 310                 315                 320 


Leu Lys Glu Val Lys Asn Leu Val Glu Lys Thr Asn Cys Glu Leu Lys 
                325                 330                 335     


Val Cys Phe Gln Tyr Leu Asn Arg Gly Asp Arg Trp Ile Gln Asp Glu 
            340                 345                 350         


Ile Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Gly Phe Pro Val Val 
        355                 360                 365             


Leu Asp Ser Pro Arg Asp Gly Asn Leu Lys Asp Phe Pro Val Lys Glu 
    370                 375                 380                 


Leu Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Leu Phe Glu 
385                 390                 395                 400 


Ser Val Thr Ser Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro 
                405                 410                 415     


Val Thr Val Asn Gly Lys Thr Tyr Pro Leu Gly Arg Ile Leu Ile Gly 
            420                 425                 430         


Ser Ser Phe Pro Leu 
        435         


<210>  5552
<211>  4602
<212>  DNA
<213>  Homosapiens

<400>  5552
attcttgaag acagctcgac cgtgatggag gagacaggca tttagaataa gcatgaaata     60

aaggtggctg ttaaggggtc agctcccctc accaaagtca cttttgattt acttacaaaa    120

gttttcttaa gatttcttca gaacccaggt caaaaggctg tggcaggagg ccaggcagat    180

cacagcgtcc atgcctagat gctccctgac ccccaggaac cagaagtgct gtctcctgaa    240

ggctctggaa acccggaatc agcctacgag gcaccagggc caccttggag ggtggaaatg    300

aggacctcag gccccagagg gcatgcaggc gaggtgaagt tcaggagagc caggaagtgt    360

ccccctcttc ccggcctgct gtatcccagg acacagggcg taagtgtgga ggaggaaggg    420

ctgcagggtg aggcagccca cactttggct caggacaggg atgggaccgg gacatatggg    480

aaaatagtct gggggtcctg ggtaatggca ggagcatgag ctcagggtcg ggtggctgtc    540

ctggatgacc tgtgggactc tcttcctctc caagccacgc tttcctcaac tgtcccttcc    600

ttgtgggatg caagaggcca cggcgagcga aggcatgtgc caagagctgc cactcaatgt    660

gagtcagcgt gctggtcctc cctccttttc tccagggggc ctaggacttt tggggggagc    720

ctgaggacat gcttcgctga tgtcactgtg tggagtgtac aaatggccac cctgctgctc    780

gttggttcta tatgggcatc caggctggag agcagggggt ggggagatgg agatgccacc    840

agcaggggac tggttcctag aagagagggc gagtttgggt ggtcccagag gtgttcttcc    900

cagaaaagag agcaggaggc aggaggtggg catggagaat gtggaggggg gcattgacag    960

tgttctccac cacccatcag ataagacctg gagcctcatt accaaagact taatgagatt   1020

cgctttgttt tcttatgagc accacacctc tctgggcctt agactcctta tccatgagct   1080

tcctgcctgc accctaacat tcagtgtcat tggccgagtt acccaatggc tcccagcctc   1140

agtttcttca tctgcacatt agggataagt acagccatcc acctgggagg tgtcaagggg   1200

gtgtggccgc agcacccagc ccatgcacaa gttcagtgat cattacctgt ctcccccagc   1260

cctgcctgag tgccaggatc agcaggcttg ggaaggggga gcccccaggg atgtggaaag   1320

tggagaggga gcacatgggc tctggggcct cggggctcct gggctctgtt ctgcctgtct   1380

gggagctgtc tcctgctctc ccttgcagtg tctctgtctc tcttcgttct gttcctccct   1440

ctgtccttca gtttttccct ctccatctca gtctctggtt gtctcagtct ctctttgcac   1500

ctcactgtct ctgcctttct ctgcatctct cttcctttcc tgggctctct ctctctcttt   1560

catccctgtt ttgggctttc tctgtctgtg tctctctgtt tttcagtctg cttctttctg   1620

tctccgttca tttctctgta tgtctttgtc ccctgcactc ccattctcct cccatgctgt   1680

cctctctggg ggctcctctg gcttcactgg gccacaggcc caggctgggg tgtgaagaag   1740

caggagctcc cccgtcagat gacgctaggt gccccagtca gggcagtggg ggccagacaa   1800

agagctctgc gaggggtggc aaaatcctct tcccagggaa gggaatgtgg gggctactgg   1860

ccagctgtgg gatgggtggc tgagaactct cataccactg taaattctag atgtttttca   1920

cttatatcag cttcctgatc cccctgagcc aaaggcctag aaggtccctg tccctgtcct   1980

tttggaatgt gcagtcttac ttaccagagt gacaagggga acagagttga aacaggtggt   2040

ttcccagcac aggagcctgt gggggctgct tagagaacag cacattccct gggagccaga   2100

gccatctggg agggctttct ggaggaggca gatcatgagg gatcaggatg gggactaata   2160

tgtgctgagt gcctggtggt gctttataag tatcagcaga ttgggagata agcatagcca   2220

ccctgtggag acacctggga ggtgtcaagg ggcatgcatt gtaaaggccc agagtggtga   2280

agcatccacc agctggtaag tggtagcctc gggtggggcc tgtcgctgtc cccatgctct   2340

gtccactact ggtgtggctt gccccacttg tgaccatcgt ttcttcccct ccacccccag   2400

tgccacttcc tctctccctc gttgtagggg aaagaacatg ggctgtgtgg ccttggacca   2460

attgcttgcc ctctctgggc cttcttattg gtgacagaca gactggtgac tttctgagag   2520

gatctatgca acctcaggct cctgcacctg ggttacaggg tcttctggag gggaagagat   2580

gagcaggtag gctttgacac ctgcctgctt tgtcctgagt gtctactatg tcatctgctt   2640

taaatgcgaa gtccctggga cttgcgagtt atctctaagc cttctctttt cctgactttc   2700

tgggagtgtg tgtaccccca ttccctcacc ccagccatca gggccctttc tgagttgggc   2760

ctccttccta gctctgggct aggccccaac cctggccctt tccaaggcca gcaggaactg   2820

gaaggtccgt actcatgccc tgggaggctc caggctctaa ggggtgctgg agtgatggag   2880

ttgggcggct ggtgctcaga ggaccttaat ggtgtgggga cagctggaaa ctggttgtct   2940

cttgaaccct cttgccacca ggcctctgtc caggagggct gctgggggcc aatgggccag   3000

acaccagaca gtcacacctt tggcagggct gaagtcgggg ggtgtgtgac acaatgggag   3060

gggctgggcc tggcagtccc tgcagcctat aagcaccagc aacccatgag gggacacagg   3120

caccctctgg cctcatcctt cttggagcca gtgggatgta gcaactaaaa tacaagctct   3180

gaagtttcat ggactggagt tgcatctctg cttccatcct aattagcaag agaccttggt   3240

cacgttgctt aaactctgac actagatttt ccccctctgc aaagcaagga caatagcagt   3300

gctcccttcc cgggtcagtt gcaaggatta aggatgatgt ctgcaaagtg cttagtcaga   3360

gccggcatac ggtaagtgct caataaatgc tggctcccat tattagtatc ccttccctcc   3420

acgccctcaa cacatccctt tatcatgatg gaataaccaa ttgcctggta acaacatgtt   3480

cacacttcca cgctccccat caaccatgct cacctataag gcaggctgcg accagctcct   3540

cttcatctat tcattgcctg gcccatgcta ggggcccaag aaatgtctgc tgcatcaacg   3600

agtgattttg ggaaaggtgc tgagcccttc tgtcccatga agttcttgcg agacagtgtc   3660

tcaccagcaa cctggatcgt gagaaccaca gcgggtgggc cagatctaga tggagagtgt   3720

ccattgggca gagctgcttc tgtgaaagga aaggaagttt ttcaagaaac catgaggggg   3780

gcccaagaat ccaagtttct aactctggga tcggttttct gtcttttacc tcggtttgcc   3840

tctccctagc tgtgtggttt atggcaagtc actctgtgcc tctgtctcca cgtgttcaag   3900

gaggcagccg gtccaagggg ccttcataga aggggctgcc gagatgtgag ccctgcattg   3960

gggggatgcc ccacagaggt gctgtccccc atcccctttc caggtatgag tgtcccccag   4020

ctctgagtga atcagtagga ggtgctggac ctgggctgat tctcacagtg ggacctcaac   4080

tctagccccg ggttggctga cattagagga ctttgggtcg ttgttctggc agctgcaagg   4140

aagagccaat gtcagggagg gaaaccccac attccctggc actatccaaa caaaggtttg   4200

gttaaaacaa agaattctca tggagaagag tctgaaggac ccaaaacaca tatttctgta   4260

gacatcccat cccaaaataa acccatggat caagccagac ccaaatacaa ggatgctgtg   4320

aaccacatgg ttgaatattc cacactttcc ccatccatta aaccccaccc agggtgggaa   4380

ggggatggat ttccctcagt tctcagggcc tagaagagca gggctttttt ccctcaactg   4440

gttgagtttt actttgtgag caccatgatt cctaaaacca gttatatttt ctttttctct   4500

tgggccgcca gggaactcac agcgaaatct accaaccaaa gaggatgtcc atacctgtct   4560

ttttctttct tccttcattt tttgacttaa tttcctcact tg                      4602


<210>  5553
<211>  140
<212>  PRT
<213>  Homosapiens

<400>  5553

Met Ser Leu Cys Gly Val Tyr Lys Trp Pro Pro Cys Cys Ser Leu Val 
1               5                   10                  15      


Leu Tyr Gly His Pro Gly Trp Arg Ala Gly Gly Gly Glu Met Glu Met 
            20                  25                  30          


Pro Pro Ala Gly Asp Trp Phe Leu Glu Glu Arg Ala Ser Leu Gly Gly 
        35                  40                  45              


Pro Arg Gly Val Leu Pro Arg Lys Glu Ser Arg Arg Gln Glu Val Gly 
    50                  55                  60                  


Met Glu Asn Val Glu Gly Gly Ile Asp Ser Val Leu His His Pro Ser 
65                  70                  75                  80  


Asp Lys Thr Trp Ser Leu Ile Thr Lys Asp Leu Met Arg Phe Ala Leu 
                85                  90                  95      


Phe Ser Tyr Glu His His Thr Ser Leu Gly Leu Arg Leu Leu Ile His 
            100                 105                 110         


Glu Leu Pro Ala Cys Thr Leu Thr Phe Ser Val Ile Gly Arg Val Thr 
        115                 120                 125             


Gln Trp Leu Pro Ala Ser Val Ser Ser Ser Ala His 
    130                 135                 140 


<210>  5554
<211>  3848
<212>  DNA
<213>  Homosapiens

<400>  5554
tcagaactca cacttcttcc tggcaaagaa gtgcccagga cgggagctgg ggagccaggg     60

ctgatctagg aggctgggag ccaggtgaca ggatggcccc aaagagagtt gtgcagctgt    120

ccctgaagat gcctacccat gccgtgtgtg tggtgggagt cgaggcacat gtggacattc    180

acagtgatgt gcccaagggt gccaacagct tcagggtctc tggaagctcc ggggtggagg    240

tcttcatggt ctacaaccgc acacgtgtga aagagcccat aggcaaggcc cgttggccgc    300

tagacactga tgcagacatg gtcgtatctg tgggcacagc cagtaaggaa ttaaaggact    360

tcaaggtgag ggtctcctac tttggggagc aggaagacca agctctgggc cgcagcgtgc    420

tttacctcac tggcgtcgat atttcccttg aggttgacac aggccgcaca ggcaaggtga    480

agaggagcca aggggacaag aaaacctggc gctggggccc tgagggctat ggggctatct    540

tgctggtgaa ctgtgaccgg gacaatcaca ggtccgcaga gcctgacctc acccacagct    600

ggctgatgtc gctggctgac ctgcaggaca tgtccccaat gctgctgagc tgcaatggcc    660

ccgacaagct cttcgacagc cacaagcttg tcttgaacgt gcccttttct gattccaaaa    720

gagtgagggt cttctgtgcc aggggtggga attctctctc ggactacaaa caggtgctgg    780

ggccccagtg tctgtcctat gaagttgagc gacagccagg ggagcaggag atcaagttct    840

atgtggaggg gctgaccttc cccgatgccg atttcctagg gctggtttcc ctcagtgtca    900

gcctggtgga cccggggacc ctgcccgagg tgaccctctt cacagacact gtgggcttcc    960

gcatggcccc ctggatcatg acgcccaaca ctcagcctcc tgaggagctg tatgtgtgca   1020

gagtgatgga cactcatggc tccaatgaga aattcctgga ggacatgtct tatctgacat   1080

tgaaagccaa ctgcaagctg accatctgcc ctcaagttga aaatcgaaat gaccgctgga   1140

tccaggacga gatggagttt ggctacatcg aggcccctca caaatccttc cccgtggtct   1200

ttgactcccc caggaacagg ggcctgaaag atttccccta taagaggatc ctgggtcctg   1260

actttggata tgttacccgg gagatcccgc tccctggtcc ctccagcctt gactccttcg   1320

gcaacctgga cgtcagcccg cccgtcacgg tgggcggcac ggaatacccc ctgggccgga   1380

tcctcatcgg gagcagcttc cccaagtccg gtgggcggca gatggccagg gcagtgcgga   1440

acttcctgaa ggcacagcag gtgcaggcac ccgtggagct ctactcggac tggctctctg   1500

tgggccatgt ggacgagttt ctgacctttg tgcctacctc tgaccaaaag ggcttccggc   1560

tgctcctggc tagccccagc gcttgcctca aactcttcca agagaagaaa gaagagggtt   1620

atggggaggc agcccagttt gatgggttaa aacaccaggc aaaaagaagc attaatgaga   1680

tgctggcaga cagacacctc cagagagaca atcttcatgc acagaaatgc attgactgga   1740

accgtaatgt gctgaagcgg gagctgggcc tggcagagag tgacatcgtg gacattcccc   1800

agctcttctt cctgaaaaac ttctacgcgg aagccttctt cccagacatg gttaacatgg   1860

tggtcttagg caagtacctg ggcatcccca agccctacgg gcccatcatc aatggccgct   1920

gctgcctgga ggagaaggtg cagtccctgc tggagcctct gggcctgcac tgcatcttca   1980

ttgatgacta cttgtcctac cacgagctgc agggggagat ccactgtggc accaacgtgc   2040

gcaggaagcc ctttcccttc aaatggtgga acatggtgcc ctgagcctgc ccccacccgc   2100

catcctctct gccctcttgc tagggaaccc tgccagggtg aaggcaagga acaaccacct   2160

ggcctccatt ctcttggggg agtcttggca ctttgcaaac atcctggcca ccatgggcac   2220

caggacacag ggatggatac cacctaccct cgcctctgga atggcctacc caacccgaga   2280

agaatgcacc tcattcttcc ctggcctctt tcccacccac agcccccaga ggctctagat   2340

caacaatgtt agcatgttcc agaatggctg tgggaggcct agggagatgg gccccactta   2400

gaattgctcc cccttcattc tgatgcctcc ctggggaaca aggataatga ctttgcatct   2460

gcacctggaa cggggcctgg gggacctggg gtctggtgtg ccaggcacca ggctgcctct   2520

gctcttggaa aactaggaaa ggggatcaga aacatcctct ccccgctcta ggtttcttct   2580

cccaaagggg acccaaggct gtgacactta cctccacccc catccagcac ccttcagctg   2640

tgtgtggaca aacaaggaca gaaaaaccca gtgtccaagg gccaatttaa atagaaaaaa   2700

agacaacaaa attttaatag ctgactccga cctcagaaga gtgattgcta cctttctgga   2760

aagactttaa ttaccagagc tggcttctcc cagctcagaa atgctgagaa gccaacgtga   2820

ggcctgagga cacacaaagg atgacggggc aggaggggat gaggtcaggg tagcagagtg   2880

tgtgacgacg gatttggggg cctagaggtg tccgtggttc ctgggctggg attttggact   2940

ctggatttga agggagctgg agcttccaga tgtagcaggg gtagggggcc agatgttaga   3000

agagggtgtg tgtgttggga ggaaattagg ttatctctga aggtggagtt taatttcctt   3060

taatagtctt taattattcc ccttcattct gcaggcagtg ggaggggaag gcttgcccgg   3120

tctctctcag caacccaggg accctgcaca tagcttaggt ttcatccctg aataaaccgc   3180

tgtgcaggcc catgtcccct cccacagtag ggaagacagc tgccacggga ggttaatagc   3240

ccggagtgag gtcactgaga catgcacagg caggctggtt cagctgggct gcagggcacg   3300

ggcaggagga agccagccta ccctcttccc ccactgccag tgaggccatt gtagggcagt   3360

tggccctagg gcttcggtcc atctaggttt tcagtggccc ctgctgagac ctcacactga   3420

gccaactact gtcactgttt taaccaacaa aagctagcct ggaactgcta tggttaaagt   3480

gggtgagcgg gaacctgaaa atccccttct ggaaggttct acagaactct atttgcaagc   3540

tcctgcttta acctgagcgt cctctgctca ggatcatacc ccagcctgca ctgagtcaag   3600

aaggagaagg aggctctgaa ggggccgggg gtgtgagctg gggttgggac tcccctgaga   3660

aagagctgtg ggtaggaagg gagtgagcat tgcagagata gggctggggg tcggggccac   3720

actgagtgtg ggaagctctg gagttgctgc tgggccatcg aggggccctg gtgttggctc   3780

tgagaatgtt ctgggtgacc agtcacctac tttctgatca ataaaaatgt cgacatgcat   3840

ttcttaca                                                            3848


<210>  5555
<211>  663
<212>  PRT
<213>  Homosapiens

<400>  5555

Met Ala Pro Lys Arg Val Val Gln Leu Ser Leu Lys Met Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Val Gly Val Glu Ala His Val Asp Ile His Ser Asp 
            20                  25                  30          


Val Pro Lys Gly Ala Asn Ser Phe Arg Val Ser Gly Ser Ser Gly Val 
        35                  40                  45              


Glu Val Phe Met Val Tyr Asn Arg Thr Arg Val Lys Glu Pro Ile Gly 
    50                  55                  60                  


Lys Ala Arg Trp Pro Leu Asp Thr Asp Ala Asp Met Val Val Ser Val 
65                  70                  75                  80  


Gly Thr Ala Ser Lys Glu Leu Lys Asp Phe Lys Val Arg Val Ser Tyr 
                85                  90                  95      


Phe Gly Glu Gln Glu Asp Gln Ala Leu Gly Arg Ser Val Leu Tyr Leu 
            100                 105                 110         


Thr Gly Val Asp Ile Ser Leu Glu Val Asp Thr Gly Arg Thr Gly Lys 
        115                 120                 125             


Val Lys Arg Ser Gln Gly Asp Lys Lys Thr Trp Arg Trp Gly Pro Glu 
    130                 135                 140                 


Gly Tyr Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn His Arg 
145                 150                 155                 160 


Ser Ala Glu Pro Asp Leu Thr His Ser Trp Leu Met Ser Leu Ala Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Pro Met Leu Leu Ser Cys Asn Gly Pro Asp Lys 
            180                 185                 190         


Leu Phe Asp Ser His Lys Leu Val Leu Asn Val Pro Phe Ser Asp Ser 
        195                 200                 205             


Lys Arg Val Arg Val Phe Cys Ala Arg Gly Gly Asn Ser Leu Ser Asp 
    210                 215                 220                 


Tyr Lys Gln Val Leu Gly Pro Gln Cys Leu Ser Tyr Glu Val Glu Arg 
225                 230                 235                 240 


Gln Pro Gly Glu Gln Glu Ile Lys Phe Tyr Val Glu Gly Leu Thr Phe 
                245                 250                 255     


Pro Asp Ala Asp Phe Leu Gly Leu Val Ser Leu Ser Val Ser Leu Val 
            260                 265                 270         


Asp Pro Gly Thr Leu Pro Glu Val Thr Leu Phe Thr Asp Thr Val Gly 
        275                 280                 285             


Phe Arg Met Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro Pro Glu 
    290                 295                 300                 


Glu Leu Tyr Val Cys Arg Val Met Asp Thr His Gly Ser Asn Glu Lys 
305                 310                 315                 320 


Phe Leu Glu Asp Met Ser Tyr Leu Thr Leu Lys Ala Asn Cys Lys Leu 
                325                 330                 335     


Thr Ile Cys Pro Gln Val Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp 
            340                 345                 350         


Glu Met Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Ser Phe Pro Val 
        355                 360                 365             


Val Phe Asp Ser Pro Arg Asn Arg Gly Leu Lys Asp Phe Pro Tyr Lys 
    370                 375                 380                 


Arg Ile Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Ile Pro Leu 
385                 390                 395                 400 


Pro Gly Pro Ser Ser Leu Asp Ser Phe Gly Asn Leu Asp Val Ser Pro 
                405                 410                 415     


Pro Val Thr Val Gly Gly Thr Glu Tyr Pro Leu Gly Arg Ile Leu Ile 
            420                 425                 430         


Gly Ser Ser Phe Pro Lys Ser Gly Gly Arg Gln Met Ala Arg Ala Val 
        435                 440                 445             


Arg Asn Phe Leu Lys Ala Gln Gln Val Gln Ala Pro Val Glu Leu Tyr 
    450                 455                 460                 


Ser Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Thr Phe Val 
465                 470                 475                 480 


Pro Thr Ser Asp Gln Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Ser 
                485                 490                 495     


Ala Cys Leu Lys Leu Phe Gln Glu Lys Lys Glu Glu Gly Tyr Gly Glu 
            500                 505                 510         


Ala Ala Gln Phe Asp Gly Leu Lys His Gln Ala Lys Arg Ser Ile Asn 
        515                 520                 525             


Glu Met Leu Ala Asp Arg His Leu Gln Arg Asp Asn Leu His Ala Gln 
    530                 535                 540                 


Lys Cys Ile Asp Trp Asn Arg Asn Val Leu Lys Arg Glu Leu Gly Leu 
545                 550                 555                 560 


Ala Glu Ser Asp Ile Val Asp Ile Pro Gln Leu Phe Phe Leu Lys Asn 
                565                 570                 575     


Phe Tyr Ala Glu Ala Phe Phe Pro Asp Met Val Asn Met Val Val Leu 
            580                 585                 590         


Gly Lys Tyr Leu Gly Ile Pro Lys Pro Tyr Gly Pro Ile Ile Asn Gly 
        595                 600                 605             


Arg Cys Cys Leu Glu Glu Lys Val Gln Ser Leu Leu Glu Pro Leu Gly 
    610                 615                 620                 


Leu His Cys Ile Phe Ile Asp Asp Tyr Leu Ser Tyr His Glu Leu Gln 
625                 630                 635                 640 


Gly Glu Ile His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Pro Phe 
                645                 650                 655     


Lys Trp Trp Asn Met Val Pro 
            660             


<210>  5556
<211>  2685
<212>  DNA
<213>  Homosapiens

<400>  5556
acacttcttc ctggcaaaga agtgcccagg acgggagctg gggagccagg gctgatctag     60

gaggctggga gccaggtgac aggatggccc caaagagagt tgtgcagctg tccctgaaga    120

tgcctaccca tgccgtgtgt gtggtgggag tcgaggcaca tgtggacatt cacagtgatg    180

tgcccaaggg tgccaacagc ttcagggtct ctggaagctc cggggtggag gtcttcatgg    240

tctacaaccg cacacgtgtg aaagagccca taggcaaggc ccgttggccg ctagacactg    300

atgcagacat ggtcgtatct gtgggcacag ccagtaagga attaaaggac ttcaaggtga    360

gggtctccta ctttggggag caggaagacc aagctctggg ccgcagcgtg ctttacctca    420

ctggcgtcga tatttccctt gaggttgaca caggccgcac aggcaaggtg aagaggagcc    480

aaggggacaa gaaaacctgg cgctggggcc ctgagggcta tggggctatc ttgctggtga    540

actgtgaccg ggacaatcac aggtccgcag agcctgacct cacccacagc tggctgatgt    600

cgctggctga cctgcaggac atgtccccaa tgctgctgag ctgcaatggc cccgacaagc    660

tcttcgacag ccacaagctt gtcttgaacg tgcccttttc tgattccaaa agagtgaggg    720

tcttctgtgc caggggtggg aattctctct cggactacaa acaggtgctg gggccccagt    780

gtctgtccta tgaagttgag cgacagccag gggagcagga gatcaagttc tatgtggagg    840

ggctgacctt ccccgatgcc gatttcctag ggctggtttc cctcagtgtc agcctggtgg    900

acccggggac cctgcccgag gtgaccctct tcacagacac tgtgggcttc cgcatggccc    960

cctggatcat gacgcccaac actcagcctc ctgaggagct gtatgtgtgc agagtgatgg   1020

acactcatgg ctccaatgag aaattcctgg aggacatgtc ttatctgaca ttgaaagcca   1080

actgcaagct gaccatctgc cctcaagttg aaaatcgaaa tgaccgctgg atccaggacg   1140

agatggagtt tggctacatc gaggcccctc acaaatcctt ccccgtggtc tttgactccc   1200

ccaggaacag gggcctgaaa gatttcccct ataagaggat cctgggtcct gactttggat   1260

atgttacccg ggagatcccg ctccctggtc cctccagcct tgactccttc ggcaacctgg   1320

acgtcagccc gcccgtcacg gtgggcggca cggaataccc cctgggccgg atcctcatcg   1380

ggagcagctt ccccaagtcc ggtgggcggc agatggccag ggcagtgcgg aacttcctga   1440

aggcacagca ggtgcaggca cccgtggagc tctactcgga ctggctctct gtgggccatg   1500

tggacgagtt tctgaccttt gtgcctacct ctgaccaaaa gggcttccgg ctgctcctgg   1560

ctagccccag cgcttgcctc aaactcttcc aagagaagaa agaagagggt tatggggagg   1620

cagcccagtt tgatgggtta aaacaccagg caaaaagaag cattaatgag atgctggcag   1680

acagacacct ccagagagac aatcttcatg cacagaaatg cattgactgg aaccgtaatg   1740

tgctgaagcg ggagctgggc ctggcagaga gtgacatcgt ggacattccc cagctcttct   1800

tcctgaaaaa cttctacgcg gaagccttct tcccagacat ggttaacatg gtggtcttag   1860

gcaagtacct gggcatcccc aagccctacg ggcccatcat caatggccgc tgctgcctgg   1920

aggagaaggt gcagtccctg ctggagcctc tgggcctgca ctgcatcttc attgatgact   1980

acttgtccta ccacgagctg cagggggaga tccactgtgg caccaacgtg cgcaggaagc   2040

cctttccctt caaatggtgg aacatggtgc cctgagcctg cccccacccg ccatcctctc   2100

tgccctcttg ctagggaacc ctgccagggt gaaggcaagg aacaaccacc tggcctccat   2160

tctcttgggg gagtcttggc actttgcaaa catcctggcc accatgggca ccaggacaca   2220

gggatggata ccacctaccc tcgcctctgg aatggcctac ccaacccgag aagaatgcac   2280

ctcattcttc cctggcctct ttcccaccca cagcccccag aggctctaga tcaacaatgt   2340

tagcatgttc cagaatggct gtgggaggcc tagggagatg ggccccactt agaattgctc   2400

ccccttcatt ctgatgcctc cctggggaac aaggataatg actttgcatc tgcacctgga   2460

acggggcctg ggggacctgg ggtctggtgt gccaggcacc aggctgcctc tgctcttgga   2520

aaactaggaa aggggatcag aaacatcctc tccccgctct aggtttcttc tcccaaaggg   2580

gacccaaggc tgtgacactt acctccaccc ccatccagca cccttcagct gtgtgtggac   2640

aaacaaggac agaaaaaccc agtgtccaag ggccaattta aatag                   2685


<210>  5557
<211>  663
<212>  PRT
<213>  Homosapiens

<400>  5557

Met Ala Pro Lys Arg Val Val Gln Leu Ser Leu Lys Met Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Val Gly Val Glu Ala His Val Asp Ile His Ser Asp 
            20                  25                  30          


Val Pro Lys Gly Ala Asn Ser Phe Arg Val Ser Gly Ser Ser Gly Val 
        35                  40                  45              


Glu Val Phe Met Val Tyr Asn Arg Thr Arg Val Lys Glu Pro Ile Gly 
    50                  55                  60                  


Lys Ala Arg Trp Pro Leu Asp Thr Asp Ala Asp Met Val Val Ser Val 
65                  70                  75                  80  


Gly Thr Ala Ser Lys Glu Leu Lys Asp Phe Lys Val Arg Val Ser Tyr 
                85                  90                  95      


Phe Gly Glu Gln Glu Asp Gln Ala Leu Gly Arg Ser Val Leu Tyr Leu 
            100                 105                 110         


Thr Gly Val Asp Ile Ser Leu Glu Val Asp Thr Gly Arg Thr Gly Lys 
        115                 120                 125             


Val Lys Arg Ser Gln Gly Asp Lys Lys Thr Trp Arg Trp Gly Pro Glu 
    130                 135                 140                 


Gly Tyr Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn His Arg 
145                 150                 155                 160 


Ser Ala Glu Pro Asp Leu Thr His Ser Trp Leu Met Ser Leu Ala Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Pro Met Leu Leu Ser Cys Asn Gly Pro Asp Lys 
            180                 185                 190         


Leu Phe Asp Ser His Lys Leu Val Leu Asn Val Pro Phe Ser Asp Ser 
        195                 200                 205             


Lys Arg Val Arg Val Phe Cys Ala Arg Gly Gly Asn Ser Leu Ser Asp 
    210                 215                 220                 


Tyr Lys Gln Val Leu Gly Pro Gln Cys Leu Ser Tyr Glu Val Glu Arg 
225                 230                 235                 240 


Gln Pro Gly Glu Gln Glu Ile Lys Phe Tyr Val Glu Gly Leu Thr Phe 
                245                 250                 255     


Pro Asp Ala Asp Phe Leu Gly Leu Val Ser Leu Ser Val Ser Leu Val 
            260                 265                 270         


Asp Pro Gly Thr Leu Pro Glu Val Thr Leu Phe Thr Asp Thr Val Gly 
        275                 280                 285             


Phe Arg Met Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro Pro Glu 
    290                 295                 300                 


Glu Leu Tyr Val Cys Arg Val Met Asp Thr His Gly Ser Asn Glu Lys 
305                 310                 315                 320 


Phe Leu Glu Asp Met Ser Tyr Leu Thr Leu Lys Ala Asn Cys Lys Leu 
                325                 330                 335     


Thr Ile Cys Pro Gln Val Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp 
            340                 345                 350         


Glu Met Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Ser Phe Pro Val 
        355                 360                 365             


Val Phe Asp Ser Pro Arg Asn Arg Gly Leu Lys Asp Phe Pro Tyr Lys 
    370                 375                 380                 


Arg Ile Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Ile Pro Leu 
385                 390                 395                 400 


Pro Gly Pro Ser Ser Leu Asp Ser Phe Gly Asn Leu Asp Val Ser Pro 
                405                 410                 415     


Pro Val Thr Val Gly Gly Thr Glu Tyr Pro Leu Gly Arg Ile Leu Ile 
            420                 425                 430         


Gly Ser Ser Phe Pro Lys Ser Gly Gly Arg Gln Met Ala Arg Ala Val 
        435                 440                 445             


Arg Asn Phe Leu Lys Ala Gln Gln Val Gln Ala Pro Val Glu Leu Tyr 
    450                 455                 460                 


Ser Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Thr Phe Val 
465                 470                 475                 480 


Pro Thr Ser Asp Gln Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Ser 
                485                 490                 495     


Ala Cys Leu Lys Leu Phe Gln Glu Lys Lys Glu Glu Gly Tyr Gly Glu 
            500                 505                 510         


Ala Ala Gln Phe Asp Gly Leu Lys His Gln Ala Lys Arg Ser Ile Asn 
        515                 520                 525             


Glu Met Leu Ala Asp Arg His Leu Gln Arg Asp Asn Leu His Ala Gln 
    530                 535                 540                 


Lys Cys Ile Asp Trp Asn Arg Asn Val Leu Lys Arg Glu Leu Gly Leu 
545                 550                 555                 560 


Ala Glu Ser Asp Ile Val Asp Ile Pro Gln Leu Phe Phe Leu Lys Asn 
                565                 570                 575     


Phe Tyr Ala Glu Ala Phe Phe Pro Asp Met Val Asn Met Val Val Leu 
            580                 585                 590         


Gly Lys Tyr Leu Gly Ile Pro Lys Pro Tyr Gly Pro Ile Ile Asn Gly 
        595                 600                 605             


Arg Cys Cys Leu Glu Glu Lys Val Gln Ser Leu Leu Glu Pro Leu Gly 
    610                 615                 620                 


Leu His Cys Ile Phe Ile Asp Asp Tyr Leu Ser Tyr His Glu Leu Gln 
625                 630                 635                 640 


Gly Glu Ile His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Pro Phe 
                645                 650                 655     


Lys Trp Trp Asn Met Val Pro 
            660             


<210>  5558
<211>  910
<212>  DNA
<213>  Homosapiens

<400>  5558
gagcggtcag ggtctgcagt tgctatgaag gtggagctga tgggatttgc tgaggggctg     60

gctgtgcgag tgagggaaca agaggagtga tgtgcccaag ggtgccaaca gcttcagggt    120

ctctggaagc tccggggtgg aggtcttcat ggtctacaac cgcacacgtg tgaaagagcc    180

cataggcaag gcccgttggc cgctagacac tgatgcagac atggtcgtat ctgtgggcac    240

agccagtaag gaattaaagg acttcaaggt gagggtctcc tactttgggg agcaggaaga    300

ccaagctctg ggccgcagcg tgctttacct cactggcgtc gatatttccc ttgaggttga    360

cacaggccgc acaggcaagg tgaagaggag ccaaggggac aagaaaacct ggcgctgggg    420

ccctgagggc tatggggcta tcttgctggt gaactgtgac cgggacaatc acaggtccgc    480

agagcctgac ctcacccaca gctggctgat gtcgctggct gacctgcagg acatgtcccc    540

aatgctgctg agctgcaatg gccccgacaa gctcttcgac agccacaagc ttgtcttgaa    600

cgtgcccttt tctgattcca aaagagtgag ggtcttctgt gccagggctt acaaacaacc    660

actccatcag taccaaatat agtcctcaag gaggaggttc aacaacaacg agttccattt    720

tatggagagg aaaaccgagg ctcagatgca ggaattcact atggcacaac catctggggt    780

ggagcaggca ttccaaccca ggtgtcttgg gtgcaccaaa gctcctcctt ttaccattgc    840

cccacacccg ttccctcctc tggtcaatca gcgtggactg aactgcatgc caagcactgt    900

ccaggcaggg                                                           910


<210>  5559
<211>  177
<212>  PRT
<213>  Homosapiens

<400>  5559

Met Val Tyr Asn Arg Thr Arg Val Lys Glu Pro Ile Gly Lys Ala Arg 
1               5                   10                  15      


Trp Pro Leu Asp Thr Asp Ala Asp Met Val Val Ser Val Gly Thr Ala 
            20                  25                  30          


Ser Lys Glu Leu Lys Asp Phe Lys Val Arg Val Ser Tyr Phe Gly Glu 
        35                  40                  45              


Gln Glu Asp Gln Ala Leu Gly Arg Ser Val Leu Tyr Leu Thr Gly Val 
    50                  55                  60                  


Asp Ile Ser Leu Glu Val Asp Thr Gly Arg Thr Gly Lys Val Lys Arg 
65                  70                  75                  80  


Ser Gln Gly Asp Lys Lys Thr Trp Arg Trp Gly Pro Glu Gly Tyr Gly 
                85                  90                  95      


Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn His Arg Ser Ala Glu 
            100                 105                 110         


Pro Asp Leu Thr His Ser Trp Leu Met Ser Leu Ala Asp Leu Gln Asp 
        115                 120                 125             


Met Ser Pro Met Leu Leu Ser Cys Asn Gly Pro Asp Lys Leu Phe Asp 
    130                 135                 140                 


Ser His Lys Leu Val Leu Asn Val Pro Phe Ser Asp Ser Lys Arg Val 
145                 150                 155                 160 


Arg Val Phe Cys Ala Arg Ala Tyr Lys Gln Pro Leu His Gln Tyr Gln 
                165                 170                 175     


Ile 
    


<210>  5560
<211>  514
<212>  DNA
<213>  Homosapiens

<400>  5560
ggacttcaga gactgggggg gtctccaggc ctcctgtgcc tctaagtagg gctgtcagga     60

tgtgtccctc atcacctctg cctccgccat ctctgaaggt gatggccgtg caggcttagg    120

gctatgttct gcaggtgagg gtctcctact ttggggagca ggaagaccaa gctctgggcc    180

gcagcgtgct ttacctcact ggcgtcgata tttcccttga ggttgacaca ggccgcacag    240

gcaaggtgaa gaggagccaa ggggacaaga aaacctggcg ctggggccct gagggctatg    300

gggctatctt gctggtgaac tgtgaccggg acaatcacag gtccgcagag cctgacctca    360

cccacagctg gctgatgtcg ctggctgacc tgcaggacat gtccccaatg ctgctgagct    420

gcaatggccc cgacaagctc ttcgacagcc acaagcttgt cttgaacgtg cccttttctg    480

attccaaaag agtgagggtc ttctgtgcca gggg                                514


<210>  5561
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  5561

Met Ser Leu Ala Asp Leu Gln Asp Met Ser Pro Met Leu Leu Ser Cys 
1               5                   10                  15      


Asn Gly Pro Asp Lys Leu Phe Asp Ser His Lys Leu Val Leu Asn Val 
            20                  25                  30          


Pro Phe Ser Asp Ser Lys Arg Val Arg Val Phe Cys Ala 
        35                  40                  45  


<210>  5562
<211>  3127
<212>  DNA
<213>  Homosapiens

<400>  5562
atgtagcccc aggctgaaga cggcctccag gcagtgctcc ctgagctatg tactgtcttt     60

ctcttcttgc agggttaaaa caccaggcaa aaagaagcat taatgagatg ctggcagaca    120

gacacctcca gagagacaat cttcatgcac aggtgagagg caggaccacc agctgctcta    180

aggggtcctt tcccttccag ggagaagaag ccccaggaac tgggttgggt cagagattca    240

gcgctggagc tctcatggtc ctgggggctg ctggggcctg caggtgggat agagcctctg    300

ccttcaggaa cccacagtct gatggaagag acagagccat gccctcagag agctcccagc    360

ctaatgaggg agacccggcc ccacgctggg gcaatgacct attttcacag aagcaaatct    420

gagcctctca tctgagaagt ctggtgaaat gcgagagaca cggtggggaa ataggacctt    480

gaggggccca gaggtggggt gggtaagatt cagggggatc ctgtgggaac aggtgaagca    540

aggtgtcagg aaggggcagg gctcacccca aggataaaaa atgcctgccc catgcaaggc    600

gaaggggcta gcacagagtc ggtgctcagt taatggcagg agggccctta ccccttcccg    660

gtagtgccca gcgctttctc ctaagctgct gagaagggac aggagcatca gccatgctgt    720

ggctggggct gggacagtgt gttgtgctga caagaacatt tgcatccaga aactgcctgg    780

gttcgaaccc cagctttggc acatcctagc cttgtgcact tgagcaggtt gcctgagcct    840

cagtttcccc cggacagcaa tggtttctat tgcacaaagc tgttgtgagg cttgaaggag    900

ctagcgggcc cagagggctc cacacgggcc cagcgcacag taggtgcttg gccagtgtta    960

tgctcttcct agtcctgggc tgcccagctg cctccttccc cagaaatgca ttgactggaa   1020

ccgtaatgtg ctgaagcggg agctgggcct ggcagagagt gacatcgtgg acattcccca   1080

gctcttcttc ctgaaaaact tctacgcgga agccttcttc ccagacatgg ttaacatggt   1140

ggtcttaggc aagtacctgg gcatccccaa gccctacggg cccatcatca atggccgctg   1200

ctgcctggag gagaaggtgc agtccctgct ggagcctctg ggcctgcact gcatcttcat   1260

tgatgactac ttgtcctacc acgagctgca gggggagatc cactgtggca ccaacgtgcg   1320

caggaagccc tttcccttca aatggtggaa catggtgccc tgagcctgcc cccacccgcc   1380

atcctctctg ccctcttgct agggaaccct gccagggtga aggcaaggaa caaccacctg   1440

gcctccattc tcttggggga gtcttggcac tttgcaaaca tcctggccac catgggcacc   1500

aggacacagg gatggatacc acctaccctc gcctctggaa tggcctaccc aacccgagaa   1560

gaatgcacct cattcttccc tggcctcttt cccacccaca gcccccagag gctctagatc   1620

aacaatgtta gcatgttcca gaatggctgt gggaggccta gggagatggg ccccacttag   1680

aattgctccc ccttcattct gatgcctccc tggggaacaa ggataatgac tttgcatctg   1740

cacctggaac ggggcctggg ggacctgggg tctggtgtgc caggcaccag gctgcctctg   1800

ctcttggaaa actaggaaag gggatcagaa acatcctctc cccgctctag gtttcttctc   1860

ccaaagggga cccaaggctg tgacacttac ctccaccccc atccagcacc cttcagctgt   1920

gtgtggacaa acaaggacag aaaaacccag tgtccaaggg ccaatttaaa tagaaaaaaa   1980

gacaacaaaa ttttaatagc tgactccgac ctcagaagag tgattgctac ctttctggaa   2040

agactttaat taccagagct ggcttctccc agctcagaaa tgctgagaag ccaacgtgag   2100

gcctgaggac acacaaagga tgacggggca ggaggggatg aggtcagggt agcagagtgt   2160

gtgacgacgg atttgggggc ctagaggtgt ccgtggttcc tgggctggga ttttggactc   2220

tggatttgaa gggagctgga gcttccagat gtagcagggg tagggggcca gatgttagaa   2280

gagggtgtgt gtgttgggag gaaattaggt tatctctgaa ggtggagttt aatttccttt   2340

aatagtcttt aattattccc cttcattctg caggcagtgg gaggggaagg cttgcccggt   2400

ctctctcagc aacccaggga ccctgcacat agcttaggtt tcatccctga ataaaccgct   2460

gtgcaggccc atgtcccctc ccacagtagg gaagacagct gccacgggag gttaatagcc   2520

cggagtgagg tcactgagac atgcacaggc aggctggttc agctgggctg cagggcacgg   2580

gcaggaggaa gccagcctac cctcttcccc cactgccagt gaggccattg tagggcagtt   2640

ggccctaggg cttcggtcca tctaggtttt cagtggcccc tgctgagacc tcacactgag   2700

ccaactactg tcactgtttt aaccaacaaa agctagcctg gaactgctat ggttaaagtg   2760

ggtgagcggg aacctgaaaa tccccttctg gaaggttcta cagaactcta tttgcaagct   2820

cctgctttaa cctgagcgtc ctctgctcag gatcataccc cagcctgcac tgagtcaaga   2880

aggagaagga ggctctgaag gggccggggg tgtgagctgg ggttgggact cccctgagaa   2940

agagctgtgg gtaggaaggg agtgagcatt gcagagatag ggctgggggt cggggccaca   3000

ctgagtgtgg gaagctctgg agttgctgct gggccatcga ggggccctgg tgttggctct   3060

gagaatgttc tgggtgacca gtcacctact ttctgatcaa taaaaatgtc gacatgcatt   3120

tcttaca                                                             3127


<210>  5563
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  5563

Met Val Asn Met Val Val Leu Gly Lys Tyr Leu Gly Ile Pro Lys Pro 
1               5                   10                  15      


Tyr Gly Pro Ile Ile Asn Gly Arg Cys Cys Leu Glu Glu Lys Val Gln 
            20                  25                  30          


Ser Leu Leu Glu Pro Leu Gly Leu His Cys Ile Phe Ile Asp Asp Tyr 
        35                  40                  45              


Leu Ser Tyr His Glu Leu Gln Gly Glu Ile His Cys Gly Thr Asn Val 
    50                  55                  60                  


Arg Arg Lys Pro Phe Pro Phe Lys Trp Trp Asn Met Val Pro 
65                  70                  75              


<210>  5564
<211>  489
<212>  DNA
<213>  Homosapiens

<400>  5564
gctgctgggg cctgcaggtg ggatagagcc tctgccttca ggaacccaca gtctgatgga     60

agagacagag ccatgccctc agagagctcc cagcctaatg agggagaccc ggccccacgc    120

tggggcaatg acctattttc acagaagcaa atctgagcct ctcatctgag aagtctggtg    180

aaaaatgcat tgactggaac cgtaatgtgc tgaagcggga gctgggcctg gcagagagtg    240

acatcgtgga cattccccag ctcttcttcc tgaaaaactt ctacgcggaa gccttcttcc    300

cagacatggt taacatggtg gtcttaggca agtacctggg catccccaag ccctacgggc    360

cacactgagt gtgggaagct ctggagttgc tgctgggcca tcgaggggcc ctggtgttgg    420

ctctgagaat gttctgggtg accagtcacc tactttctga tcaataaaaa tgtcgacatg    480

catttctta                                                            489


<210>  5565
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  5565

Met Glu Glu Thr Glu Pro Cys Pro Gln Arg Ala Pro Ser Leu Met Arg 
1               5                   10                  15      


Glu Thr Arg Pro His Ala Gly Ala Met Thr Tyr Phe His Arg Ser Lys 
            20                  25                  30          


Ser Glu Pro Leu Ile 
        35          


<210>  5566
<211>  3186
<212>  DNA
<213>  Homosapiens

<400>  5566
agtgttgggg ttggcggcca cagctaagtc caacaccagc atgtcgctgc agagaatcgt     60

gcgtgtgtcc ctggagcatc ccaccagcgc ggtgtgtgtg gctggcgtgg agaccctcgt    120

ggacatttat gggtcagtgc ctgagggcac agaaatgttt gaggtctatg ggacgcctgg    180

cgtggacatc tacatctctc ccaacatgga gaggggccgg gagcgtgcag acaccaggcg    240

gtggcgcttt gacgcgactt tggagatcat cgtggtcatg aactccccca gcaatgacct    300

caacgacagc catgttcaga tttcctacca ctccagccat gagcctctgc ccctggccta    360

tgcggtgctc tacctcacct gtgttgacat ctctctggat tgcgacctga actgtgaggg    420

aaggcaggac aggaactttg tagacaagcg gcagtgggtc tgggggccca gtgggtatgg    480

cggcatcttg ctggtgaact gtgaccgtga tgatccgagc tgtgatgtcc aggacaattg    540

tgaccagcac gtgcactgcc tgcaagacct ggaagacatg tctgtcatgg tcctgcggac    600

gcagggccct gcagccctct ttgatgacca caaacttgtc ctccatacct ccagctatga    660

tgccaaacgg gcacaggtct tccacatctg cggtcctgag gatgtgtgtg aggcctatag    720

gcatgtgctg ggccaagata aggtgtccta tgaggtaccc cgcttgcatg gggatgagga    780

gcgcttcttc gtggaaggcc tgtccttccc tgatgccggc ttcacaggac tcatctcctt    840

ccatgtcact ctgctggacg actccaacga ggatttctcg gcatccccta tcttcactga    900

cactgtggtg ttccgagtgg caccctggat catgacgccc agcactctgc cacccctaga    960

ggtgtatgtg tgccgtgtga ggaacaacac gtgttttgtg gatgcggtgg cagagctggc   1020

caggaaggcc ggctgcaagc tgaccatctg cccacaggcc gagaaccgca acgaccgctg   1080

gatccaggat gagatggagc tgggctacgt tcaggcgccg cacaagaccc tcccggtggt   1140

ctttgactcc ccaaggaatg gggaactgca ggatttccct tacaaaagaa tcctgggtcc   1200

agattttggt tacgtgactc gggaaccacg cgacaggtct gtgagtggcc tggactcctt   1260

tgggaacctg gaggtcagcc ctccagtggt ggccaatggg aaagagtacc ccctggggag   1320

gatcctcatt gggggcaacc tgcctgggtc aagtggccgc agggtcaccc aggtggtgcg   1380

ggacttcctc catgcccaga aggtgcagcc ccccgtggag ctctttgtgg actggttggc   1440

cgtgggccat gtggatgagt ttctgagctt tgtccctgcc cccgatggga agggcttccg   1500

gatgctcctg gccagccctg gggcctgctt caagctcttc caggaaaagc agaagtgtgg   1560

ccacgggagg gccctcctgt tccagggggt tgttgatgat gagcaggtca agaccatctc   1620

catcaaccag gtgctctcca ataaagacct catcaactac aataagtttg tgcagagctg   1680

catcgactgg aaccgtgagg tgctgaagcg ggagctgggc ctggcagagt gtgacatcat   1740

tgacatccca cagctcttca agaccgagag gaaaaaagca acggccttct tccctgactt   1800

ggtgaacatg ctggtgctgg ggaagcacct gggcatcccc aagccctttg ggcccatcat   1860

caatggctgc tgctgcctgg aggagaaggt gcggtccctg ctggagccgc tgggcctcca   1920

ctgcaccttc attgatgact tcactccata ccacatgctg catggggagg tgcactgtgg   1980

caccaatgtg tgcagaaagc ccttctcttt caagtggtgg aacatggtgc cctgagacag   2040

ctcccaccca ccatcctgtc cccctggggc gggcattggc ccaggtggtg gagacagaga   2100

caggcccctg aacgataagc accaagagac cccaaggctc cagatggaac actgagggtg   2160

accgtccctc tcagaagcct tttccctgga agtgtccatg cctcacctgc aacccatgtg   2220

gttctcagac ttgaatcttc tcggcccccc aaaaagaagg acctcatttc ttatagcctc   2280

tcctgtgatt caacacaacc catggagatg tccccttctc actctgaaat catccatttg   2340

gggacaaatc cacattgggg tctagaaaca tccacgtatc tcatcagcca tcttgtcctg   2400

tgcatcctaa cagaggaagg atccatgatt ctgctttggt ccaattgctt cctctctgca   2460

gaggaacaac cctaaaacca gaccactcca cgcaggacag gcaggagaga ttcttcctaa   2520

agcctccccc ataaaaaggg agctgtggat ccacttagat cagggcggaa ccatctttca   2580

cccggccaag ctcctgccca gatgttgacc ctcacccagc gtgagctgtc acatagtagg   2640

agcttctaga tgcatgtgga agcaatgaga gttgtccctt agccttataa actccccatg   2700

atctgacatg cagaaatcca gccttgtcca gaatcctcct ggaatttctt ggagacgaaa   2760

gtatctgggg gattgttggg tactagggag actgggtaca agggtgaaaa gtagttccca   2820

taatacacat ggttgactat ggtgatccac cttgtgatgg ttaatattag gtgtctggag   2880

aaggttgctt cattggccct gggacttctc tctgcaggag gagagaacgc tgcctctcct   2940

ctggattggt ctcaggctct ctgttggcct ttggtcagcg tttccacatc ctgctctgct   3000

gcaggagagg gggctaaggg gctggatcca ccaaggcagc tcacagcggg aaaactctgg   3060

gaatgaacca ctgaattcag gggatggggg tgggggggcg gttctcgagg tgtgtgccag   3120

ctacacgtgt gttctgtatg ggtccagctg cgtttccatc actcgctaat aaatcaacag   3180

aaacac                                                              3186


<210>  5567
<211>  664
<212>  PRT
<213>  Homosapiens

<400>  5567

Met Ser Leu Gln Arg Ile Val Arg Val Ser Leu Glu His Pro Thr Ser 
1               5                   10                  15      


Ala Val Cys Val Ala Gly Val Glu Thr Leu Val Asp Ile Tyr Gly Ser 
            20                  25                  30          


Val Pro Glu Gly Thr Glu Met Phe Glu Val Tyr Gly Thr Pro Gly Val 
        35                  40                  45              


Asp Ile Tyr Ile Ser Pro Asn Met Glu Arg Gly Arg Glu Arg Ala Asp 
    50                  55                  60                  


Thr Arg Arg Trp Arg Phe Asp Ala Thr Leu Glu Ile Ile Val Val Met 
65                  70                  75                  80  


Asn Ser Pro Ser Asn Asp Leu Asn Asp Ser His Val Gln Ile Ser Tyr 
                85                  90                  95      


His Ser Ser His Glu Pro Leu Pro Leu Ala Tyr Ala Val Leu Tyr Leu 
            100                 105                 110         


Thr Cys Val Asp Ile Ser Leu Asp Cys Asp Leu Asn Cys Glu Gly Arg 
        115                 120                 125             


Gln Asp Arg Asn Phe Val Asp Lys Arg Gln Trp Val Trp Gly Pro Ser 
    130                 135                 140                 


Gly Tyr Gly Gly Ile Leu Leu Val Asn Cys Asp Arg Asp Asp Pro Ser 
145                 150                 155                 160 


Cys Asp Val Gln Asp Asn Cys Asp Gln His Val His Cys Leu Gln Asp 
                165                 170                 175     


Leu Glu Asp Met Ser Val Met Val Leu Arg Thr Gln Gly Pro Ala Ala 
            180                 185                 190         


Leu Phe Asp Asp His Lys Leu Val Leu His Thr Ser Ser Tyr Asp Ala 
        195                 200                 205             


Lys Arg Ala Gln Val Phe His Ile Cys Gly Pro Glu Asp Val Cys Glu 
    210                 215                 220                 


Ala Tyr Arg His Val Leu Gly Gln Asp Lys Val Ser Tyr Glu Val Pro 
225                 230                 235                 240 


Arg Leu His Gly Asp Glu Glu Arg Phe Phe Val Glu Gly Leu Ser Phe 
                245                 250                 255     


Pro Asp Ala Gly Phe Thr Gly Leu Ile Ser Phe His Val Thr Leu Leu 
            260                 265                 270         


Asp Asp Ser Asn Glu Asp Phe Ser Ala Ser Pro Ile Phe Thr Asp Thr 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Ser Thr Leu Pro 
    290                 295                 300                 


Pro Leu Glu Val Tyr Val Cys Arg Val Arg Asn Asn Thr Cys Phe Val 
305                 310                 315                 320 


Asp Ala Val Ala Glu Leu Ala Arg Lys Ala Gly Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Gln Ala Glu Asn Arg Asn Asp Arg Trp Ile Gln Asp Glu Met 
            340                 345                 350         


Glu Leu Gly Tyr Val Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Gly Glu Leu Gln Asp Phe Pro Tyr Lys Arg Ile 
    370                 375                 380                 


Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Arg Asp Arg Ser 
385                 390                 395                 400 


Val Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Val Ala Asn Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Ile Gly Gly 
            420                 425                 430         


Asn Leu Pro Gly Ser Ser Gly Arg Arg Val Thr Gln Val Val Arg Asp 
        435                 440                 445             


Phe Leu His Ala Gln Lys Val Gln Pro Pro Val Glu Leu Phe Val Asp 
    450                 455                 460                 


Trp Leu Ala Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro Ala 
465                 470                 475                 480 


Pro Asp Gly Lys Gly Phe Arg Met Leu Leu Ala Ser Pro Gly Ala Cys 
                485                 490                 495     


Phe Lys Leu Phe Gln Glu Lys Gln Lys Cys Gly His Gly Arg Ala Leu 
            500                 505                 510         


Leu Phe Gln Gly Val Val Asp Asp Glu Gln Val Lys Thr Ile Ser Ile 
        515                 520                 525             


Asn Gln Val Leu Ser Asn Lys Asp Leu Ile Asn Tyr Asn Lys Phe Val 
    530                 535                 540                 


Gln Ser Cys Ile Asp Trp Asn Arg Glu Val Leu Lys Arg Glu Leu Gly 
545                 550                 555                 560 


Leu Ala Glu Cys Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Thr Glu 
                565                 570                 575     


Arg Lys Lys Ala Thr Ala Phe Phe Pro Asp Leu Val Asn Met Leu Val 
            580                 585                 590         


Leu Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Ile Ile Asn 
        595                 600                 605             


Gly Cys Cys Cys Leu Glu Glu Lys Val Arg Ser Leu Leu Glu Pro Leu 
    610                 615                 620                 


Gly Leu His Cys Thr Phe Ile Asp Asp Phe Thr Pro Tyr His Met Leu 
625                 630                 635                 640 


His Gly Glu Val His Cys Gly Thr Asn Val Cys Arg Lys Pro Phe Ser 
                645                 650                 655     


Phe Lys Trp Trp Asn Met Val Pro 
            660                 


<210>  5568
<211>  2269
<212>  DNA
<213>  Homosapiens

<400>  5568
tacagccaga gggacgagct agcccgacga tggcccaggg gacattgatc cgtgtgaccc     60

cagagcagcc cacccatgcc gtgtgtgtgc tgggcacctt gactcagctt gacatctgca    120

gctctgcccc tgaggactgc acgtccttca gcatcaacgc ctccccaggg gtggtcgtgg    180

atattgccca cggccctcca gccaagaaga aatccacagg ttcctccaca tggcccctgg    240

accctggggt agaggtgacc ctgacgatga aagtggccag tggtagcaca ggcgaccaga    300

aggttcagat ttcatactac ggacccaaga ctccaccagt caaagctcta ctctacctca    360

ccggggtgga aatctccttg tgcgcagaca tcacccgcac cggcaaagtg aagccaacca    420

gagctgtgaa agatcagagg acctggacct ggggcccttg tggacagggt gccatcctgc    480

tggtgaactg tgacagagac aatctcgaat cttctgccat ggactgcgag gatgatgaag    540

tgcttgacag cgaagacctg caggacatgt cgctgatgac cctgagcacg aagaccccca    600

aggacttctt cacaaaccat acactggtgc tccacgtggc caggtctgag atggacaaag    660

tgagggtgtt tcaggccaca cggggcaaac tgtcctccaa gtgcagcgta gtcttgggtc    720

ccaagtggcc ctctcactac ctgatggtcc ccggtggaaa gcacaacatg gacttctacg    780

tggaggccct cgctttcccg gacaccgact tcccggggct cattaccctc accatctccc    840

tgctggacac gtccaacctg gagctccccg aggctgtggt gttccaagac agcgtggtct    900

tccgcgtggc gccctggatc atgaccccca acacccagcc cccgcaggag gtgtacgcgt    960

gcagtatttt tgaaaatgag gacttcctga agtcagtgac tactctggcc atgaaagcca   1020

agtgcaagct gaccatctgc cctgaggagg agaacatgga tgaccagtgg atgcaggatg   1080

aaatggagat cggctacatc caagccccac acaaaacgct gcccgtggtc ttcgactctc   1140

caaggaacag aggcctgaag gagtttccca tcaaacgcgt gatgggtcca gattttggct   1200

atgtaactcg agggccccaa acagggggta tcagtggact ggactccttt gggaacctgg   1260

aagtgagccc cccagtcaca gtcaggggca aggaataccc gctgggcagg attctcttcg   1320

gggacagctg ttatcccagc aatgacagcc ggcagatgca ccaggccctg caggacttcc   1380

tcagtgccca gcaggtgcag gcccctgtga agctctattc tgactggctg tccgtgggcc   1440

acgtggacga gttcctgagc tttgtgccag cacccgacag gaagggcttc cggctgctcc   1500

tggccagccc caggtcctgc tacaaactgt tccaggagca gcagaatgag ggccacgggg   1560

aggccctgct gttcgaaggg atcaagaaaa aaaaacagca gaaaataaag aacattctgt   1620

caaacaagac attgagagaa cataattcat ttgtggagag atgcatcgac tggaaccgcg   1680

agctgctgaa gcgggagctg ggcctggccg agagtgacat cattgacatc ccgcagctct   1740

tcaagctcaa agagttctct aaggcggaag cttttttccc caacatggtg aacatgctgg   1800

tgctagggaa gcacctgggc atccccaagc ccttcgggcc cgtcatcaac ggccgctgct   1860

gcctggagga gaaggtgtgt tccctgctgg agccactggg cctccagtgc accttcatca   1920

acgacttctt cacctaccac atcaggcatg gggaggtgca ctgcggcacc aacgtgcgca   1980

gaaagccctt ctccttcaag tggtggaaca tggtgccctg agcccatctt ccctggcgtc   2040

ctctccctcc tggccagatg tcgctgggtc ctctgcagtg tggcaagcaa gagctcttgt   2100

gaatattgtg gctccctggg ggcggccagc cctcccagca gtggcttgct ttcttctcct   2160

gtgatgtccc agtttcccac tctgaagatc ccaacatggt cctagcactg cacactcagt   2220

tctgctctaa gaagctgcaa taaagttttt ttaagtcact ttgtacatg               2269


<210>  5569
<211>  663
<212>  PRT
<213>  Homosapiens

<400>  5569

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Gly Pro Asp Phe Gly Tyr Val Thr Arg Gly Pro Gln Thr Gly Gly 
385                 390                 395                 400 


Ile Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Thr Val Arg Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Phe Gly Asp 
            420                 425                 430         


Ser Cys Tyr Pro Ser Asn Asp Ser Arg Gln Met His Gln Ala Leu Gln 
        435                 440                 445             


Asp Phe Leu Ser Ala Gln Gln Val Gln Ala Pro Val Lys Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro 
465                 470                 475                 480 


Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser 
                485                 490                 495     


Cys Tyr Lys Leu Phe Gln Glu Gln Gln Asn Glu Gly His Gly Glu Ala 
            500                 505                 510         


Leu Leu Phe Glu Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile Lys Asn 
        515                 520                 525             


Ile Leu Ser Asn Lys Thr Leu Arg Glu His Asn Ser Phe Val Glu Arg 
    530                 535                 540                 


Cys Ile Asp Trp Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly Leu Ala 
545                 550                 555                 560 


Glu Ser Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys Glu Phe 
                565                 570                 575     


Ser Lys Ala Glu Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu 
            580                 585                 590         


Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Val Ile Asn Gly 
        595                 600                 605             


Arg Cys Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly 
    610                 615                 620                 


Leu Gln Cys Thr Phe Ile Asn Asp Phe Phe Thr Tyr His Ile Arg His 
625                 630                 635                 640 


Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Ser Phe 
                645                 650                 655     


Lys Trp Trp Asn Met Val Pro 
            660             


<210>  5570
<211>  841
<212>  DNA
<213>  Homosapiens

<400>  5570
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc     60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag    120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga    180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga    240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa    300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac    360

cggggtggat ggagtctcac cctgtcaccc aggctggagt gcaatggcat gatctcggct    420

cactgcaacc tgcgtctccc aggttcaagc gatcctcctg cttcagcgtc cctagtagct    480

gggactacag gcgcttgcca ccacgcctgg ctaatttttg tatttttagt agagatggag    540

tttcaccatg ttggccaggc tggtctcgaa cttctgacct caggtgatct gcctgcctca    600

ggctcccaaa gtgctcggat tactggcatg aaccactgcg ccaggccctc tattcctttt    660

tgatacctca aatatctata acaaaaagta gataatgaca ctgtcttata caagaatata    720

gatagtgttc ctcaaattcc attatttata tctcatcttc accatttctg ccatatcaat    780

gatccaccta tactcatatt tatgtaatgt tcttctttaa ataaaatcca ttcttaaact    840

t                                                                    841


<210>  5571
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  5571

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Asp Gly Val Ser Pro Cys His Pro Gly Trp Ser Ala Met Ala 
        115                 120                 125         


<210>  5572
<211>  1097
<212>  DNA
<213>  Homosapiens

<400>  5572
ggggtaccca ctagttcctg cctcataact tgttagatgg attccatgag ctaatgcctg     60

ctaagagcag atggaccgga cgtgccagga gcctctgttc aggccacagg tgacccctga    120

gccacctgtg tgtccctccc aatccttcca ggctgagctt caaattccag agcactaagg    180

agctgctttt ctgctctctc tagtattttt gaaaatgagg acttcctgaa gtcagtgact    240

actctggcca tgaaagccaa gtgcaagctg accatctgcc ctgaggagga gaacatggat    300

gaccagtgga tgcaggatga aatggagatc ggctacatcc aagccccaca caaaacgctg    360

cccgtggtct tcgactctcc aaggaacaga ggcctgaagg agtttcccat caaacgcgtg    420

atggtacctg catggggtgg ggagggggca cagctgccga aaccctcttg tcttgagact    480

ccctcctttt agcctgcctt ccccgcccgc gcctgtagct gagtagccca gtgcaaggag    540

gtggaattcc taccaaagtg ggagcatgta ggtggggctt gttatttttt tattaccaag    600

ataagatctg gctcttcatt tcccaaaacc cttgtcaccc gtgagctcag cttgatctcc    660

aggtaaccct gccgaggagg tggctcaggc ttggacctcc ctgtgctctt gaagaagctc    720

ttgctgcaag gtggaggtgg ggccggggct ggaatctttc ccaatgccca gctggaggct    780

ctgtcttatg ggtggtgttt ggtcttcagg ggctccatct gggatatggg ggattttggg    840

atcagtggat cagtggtcat ttcctgggtg tgactttatc agccacaggc tgtccatgtg    900

gaggtgggaa gtgacgtatt gctgactcat gcttgactag cctggcaggt tgatgcaaac    960

tcagcacaga acaataataa taatagttgc atttattgag aatgagttgt gtgttagcca   1020

gtgctgcatt ctttacctgc actgactcat ttaatttgat aaactgttat ggagattcta   1080

tcaataggcc catttta                                                  1097


<210>  5573
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  5573

Met Lys Ala Lys Cys Lys Leu Thr Ile Cys Pro Glu Glu Glu Asn Met 
1               5                   10                  15      


Asp Asp Gln Trp Met Gln Asp Glu Met Glu Ile Gly Tyr Ile Gln Ala 
            20                  25                  30          


Pro His Lys Thr Leu Pro Val Val Phe Asp Ser Pro Arg Asn Arg Gly 
        35                  40                  45              


Leu Lys Glu Phe Pro Ile Lys Arg Val Met Val Pro Ala Trp Gly Gly 
    50                  55                  60                  


Glu Gly Ala Gln Leu Pro Lys Pro Ser Cys Leu Glu Thr Pro Ser Phe 
65                  70                  75                  80  


<210>  5574
<211>  1995
<212>  DNA
<213>  Homosapiens

<400>  5574
atggtcagcg tggagggccg agccatgtcc ttccagagta tcatccacct gtccctggac     60

agccctgtcc atgccgtttg tgtgttgggc acagaaatct gcttggatct cagcgggtgt    120

gccccccaga agtgccagtg cttcaccatc catggctctg ggagggtctt gatcgatgtg    180

gccaacacgg tgatttctga gaaggaggac gccaccatct ggtggcccct gtctgatccc    240

acgtacgcca cagtgaagat gacatcgccc agcccttccg tggatgcgga taaggtctcg    300

gtcacatact atgggcccaa cgaggatgcc cccgtgggca cagctgtgct gtacctcact    360

ggcattgagg tctctctaga ggtagacatc taccgcaatg ggcaagttga gatgtcaagt    420

gacaaacagg ctaagcccaa ttgctgtgac attgctgaag gattagatac gtggagggga    480

gggaaaaaat ggatctgggg tcccagcggt tggggtgcca tcctgcttgt gaattgcaac    540

cctgctgatg tgggccagca acttgaggac aagaaaacca agaaagtgat cttttcagag    600

gaaataacga atctgtccca gatgactctg aatgtccaag gccccagctg tatcttaaag    660

aaatatcggc tagtcctcca tacctccaag gaagagtcga agaaggcgag agtctactgg    720

ccccaaaaag acaactccag tacctttgag ttggtgctgg ggcccgacca gcacgcctat    780

accttggccc tcctcgggaa ccacttgaag gagactttct acgttgaagc tatagcattc    840

ccatctgccg aattctcagg cctcatctcc tactctgtgt ccctggtgga ggagtctcaa    900

gacccgtcaa ttccagagac tgtgctgtac aaagacacgg tggtgttccg ggtggctccc    960

tgtgtcttca ttccctgtac ccaggatgag atggccttct gctacaccca ggctccccac   1020

aagacaacgt ccttgatcct cgacacacct caggccgccg atctcgatga gttccccatg   1080

aagtactcac tgagccctgg tattggctac atgatccagg acactgagga ccataaagtg   1140

gccagcatgg attccattgg gaacctgatg gtgtccccac ctgtcaaggt ccaagggaaa   1200

gagtacccgc tgggcagagt cctcattggc agcagctttt accccagcgc agagggccgg   1260

gccatgagta agaccctccg agacttcctc tatgcccagc aggtccaagc gccggtggag   1320

ctctactcag attggctaat gactggccac gtggatgagt tcatgtgctt catccccaca   1380

gatgacaaga atgagggcaa aaagggcttc ctgctgctcc tggccagccc cagtgcctgc   1440

tataaactgt tccgagagaa acagaaggaa ggctatggcg acgctcttct gtttgatgag   1500

cttagagcag atcagctcct gtctaatgga agggaagcca aaaccatcga ccaacttctg   1560

gctgatgaaa gcctgaagaa gcagaatgaa tacgtggaga agtgcattca cctgaaccgt   1620

gacatcctga agacggagct gggcctggtg gaacaggaca tcatcgagat tccccagctg   1680

ttctgcttgg agaagctgac taacatcccc tctgaccagc agcccaagag gtcctttgcg   1740

aggccatact tccctgacct gttgcggatg attgtgatgg gcaagaacct ggggatcccc   1800

aagccttttg ggccccaaat caaggggacc tgctgcctgg aagaaaagat ttgctgcttg   1860

ctggagcccc tgggcttcaa gtgcaccttc atcaatgact ttgactgtta cctgacagag   1920

gtcggagaca tctgtgcctg tgccaacatc cgccgggtgc cctttgcctt caaatggtgg   1980

aagatggtac cttag                                                    1995


<210>  5575
<211>  664
<212>  PRT
<213>  Homosapiens

<400>  5575

Met Val Ser Val Glu Gly Arg Ala Met Ser Phe Gln Ser Ile Ile His 
1               5                   10                  15      


Leu Ser Leu Asp Ser Pro Val His Ala Val Cys Val Leu Gly Thr Glu 
            20                  25                  30          


Ile Cys Leu Asp Leu Ser Gly Cys Ala Pro Gln Lys Cys Gln Cys Phe 
        35                  40                  45              


Thr Ile His Gly Ser Gly Arg Val Leu Ile Asp Val Ala Asn Thr Val 
    50                  55                  60                  


Ile Ser Glu Lys Glu Asp Ala Thr Ile Trp Trp Pro Leu Ser Asp Pro 
65                  70                  75                  80  


Thr Tyr Ala Thr Val Lys Met Thr Ser Pro Ser Pro Ser Val Asp Ala 
                85                  90                  95      


Asp Lys Val Ser Val Thr Tyr Tyr Gly Pro Asn Glu Asp Ala Pro Val 
            100                 105                 110         


Gly Thr Ala Val Leu Tyr Leu Thr Gly Ile Glu Val Ser Leu Glu Val 
        115                 120                 125             


Asp Ile Tyr Arg Asn Gly Gln Val Glu Met Ser Ser Asp Lys Gln Ala 
    130                 135                 140                 


Lys Pro Asn Cys Cys Asp Ile Ala Glu Gly Leu Asp Thr Trp Arg Gly 
145                 150                 155                 160 


Gly Lys Lys Trp Ile Trp Gly Pro Ser Gly Trp Gly Ala Ile Leu Leu 
                165                 170                 175     


Val Asn Cys Asn Pro Ala Asp Val Gly Gln Gln Leu Glu Asp Lys Lys 
            180                 185                 190         


Thr Lys Lys Val Ile Phe Ser Glu Glu Ile Thr Asn Leu Ser Gln Met 
        195                 200                 205             


Thr Leu Asn Val Gln Gly Pro Ser Cys Ile Leu Lys Lys Tyr Arg Leu 
    210                 215                 220                 


Val Leu His Thr Ser Lys Glu Glu Ser Lys Lys Ala Arg Val Tyr Trp 
225                 230                 235                 240 


Pro Gln Lys Asp Asn Ser Ser Thr Phe Glu Leu Val Leu Gly Pro Asp 
                245                 250                 255     


Gln His Ala Tyr Thr Leu Ala Leu Leu Gly Asn His Leu Lys Glu Thr 
            260                 265                 270         


Phe Tyr Val Glu Ala Ile Ala Phe Pro Ser Ala Glu Phe Ser Gly Leu 
        275                 280                 285             


Ile Ser Tyr Ser Val Ser Leu Val Glu Glu Ser Gln Asp Pro Ser Ile 
    290                 295                 300                 


Pro Glu Thr Val Leu Tyr Lys Asp Thr Val Val Phe Arg Val Ala Pro 
305                 310                 315                 320 


Cys Val Phe Ile Pro Cys Thr Gln Asp Glu Met Ala Phe Cys Tyr Thr 
                325                 330                 335     


Gln Ala Pro His Lys Thr Thr Ser Leu Ile Leu Asp Thr Pro Gln Ala 
            340                 345                 350         


Ala Asp Leu Asp Glu Phe Pro Met Lys Tyr Ser Leu Ser Pro Gly Ile 
        355                 360                 365             


Gly Tyr Met Ile Gln Asp Thr Glu Asp His Lys Val Ala Ser Met Asp 
    370                 375                 380                 


Ser Ile Gly Asn Leu Met Val Ser Pro Pro Val Lys Val Gln Gly Lys 
385                 390                 395                 400 


Glu Tyr Pro Leu Gly Arg Val Leu Ile Gly Ser Ser Phe Tyr Pro Ser 
                405                 410                 415     


Ala Glu Gly Arg Ala Met Ser Lys Thr Leu Arg Asp Phe Leu Tyr Ala 
            420                 425                 430         


Gln Gln Val Gln Ala Pro Val Glu Leu Tyr Ser Asp Trp Leu Met Thr 
        435                 440                 445             


Gly His Val Asp Glu Phe Met Cys Phe Ile Pro Thr Asp Asp Lys Asn 
    450                 455                 460                 


Glu Gly Lys Lys Gly Phe Leu Leu Leu Leu Ala Ser Pro Ser Ala Cys 
465                 470                 475                 480 


Tyr Lys Leu Phe Arg Glu Lys Gln Lys Glu Gly Tyr Gly Asp Ala Leu 
                485                 490                 495     


Leu Phe Asp Glu Leu Arg Ala Asp Gln Leu Leu Ser Asn Gly Arg Glu 
            500                 505                 510         


Ala Lys Thr Ile Asp Gln Leu Leu Ala Asp Glu Ser Leu Lys Lys Gln 
        515                 520                 525             


Asn Glu Tyr Val Glu Lys Cys Ile His Leu Asn Arg Asp Ile Leu Lys 
    530                 535                 540                 


Thr Glu Leu Gly Leu Val Glu Gln Asp Ile Ile Glu Ile Pro Gln Leu 
545                 550                 555                 560 


Phe Cys Leu Glu Lys Leu Thr Asn Ile Pro Ser Asp Gln Gln Pro Lys 
                565                 570                 575     


Arg Ser Phe Ala Arg Pro Tyr Phe Pro Asp Leu Leu Arg Met Ile Val 
            580                 585                 590         


Met Gly Lys Asn Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Ile Lys 
        595                 600                 605             


Gly Thr Cys Cys Leu Glu Glu Lys Ile Cys Cys Leu Leu Glu Pro Leu 
    610                 615                 620                 


Gly Phe Lys Cys Thr Phe Ile Asn Asp Phe Asp Cys Tyr Leu Thr Glu 
625                 630                 635                 640 


Val Gly Asp Ile Cys Ala Cys Ala Asn Ile Arg Arg Val Pro Phe Ala 
                645                 650                 655     


Phe Lys Trp Trp Lys Met Val Pro 
            660                 


<210>  5576
<211>  2111
<212>  DNA
<213>  Homosapiens

<400>  5576
atggtcagcg tggagggccg agccatgtcc ttccagagta tcatccacct gtccctggac     60

agccctgtcc atgccgtttg tgtgttgggc acagaaatct gcttggatct cagcgggtgt    120

gccccccaga agtgccagtg cttcaccatc catggctctg ggagggtctt gatcgatgtg    180

gccaacacgg tgatttctga gaaggaggac gccaccatct ggtggcccct gtctgatccc    240

acgtacgcca cagtgaagat gacatcgccc agcccttccg tggatgcgga taaggtctcg    300

gtcacatact atgggcccaa cgaggatgcc cccgtgggca cagctgtgct gtacctcact    360

ggcattgagg tctctctaga ggtagacatc taccgcaatg ggcaagttga gatgtcaagt    420

gacaaacagg ctaagaaaaa atggatctgg ggtcccagcg gttggggtgc catcctgctt    480

gtgaattgca accctgctga tgtgggccag caacttgagg acaagaaaac caagaaagtg    540

atcttttcag aggaaataac gaatctgtcc cagatgactc tgaatgtcca aggccccagc    600

tgtatcttaa agaaatatcg gctagtcctc catacctcca aggaagagtc gaagaaggcg    660

agagtctact ggccccaaaa agacaactcc agtacctttg agttggtgct ggggcccgac    720

cagcacgcct ataccttggc cctcctcggg aaccacttga aggagacttt ctacgttgaa    780

gctatagcat tcccatctgc cgaattctca ggcctcatct cctactctgt gtccctggtg    840

gaggagtctc aagacccgtc aattccagag actgtgctgt acaaagacac ggtggtgttc    900

cgggtggctc cctgtgtctt cattccctgt acccaggtgc ctctggaggt ttacctgtgc    960

agggagctgc agctgcaggg ttttgtggac acagtgacga agctgagtga gaagagcaac   1020

agccagggtg gcatctgtct atgaggaccc caaccgcctg ggcaggtggc tccaggatga   1080

gatggccttc tgctacaccc aggctcccca caagacaacg tccttgatcc tcgacacacc   1140

tcaggccgcc gatctcgatg agttccccat gaagtactca ctgagccctg gtattggcta   1200

catgatccag gacactgagg accataaagt ggccagcatg gattccattg ggaacctgat   1260

ggtgtcccca cctgtcaagg tccaagggaa agagtacccg ctgggcagag tcctcattgg   1320

cagcagcttt taccccagcg cagagggccg ggccatgagt aagaccctcc gagacttcct   1380

ctatgcccag caggtccaag cgccggtgga gctctactca gattggctaa tgactggcca   1440

cgtggatgag ttcatgtgct tcatccccac agatgacaag aatgagggca aaaagggctt   1500

cctgctgctc ctggccagcc ccagtgcctg ctataaactg ttccgagaga aacagaagga   1560

aggctatggc gacgctcttc tgtttgatga gcttagagca gatcagctcc tgtctaatgg   1620

aagggaagcc aaaaccatcg accaacttct ggctgatgaa agcctgaaga agcagaatga   1680

atacgtggag aagtgcattc acctgaaccg tgacatcctg aagacggagc tgggcctggt   1740

ggaacaggac atcatcgaga ttccccagct gttctgcttg gagaagctga ctaacatccc   1800

ctctgaccag cagcccaaga ggtcctttgc gaggccatac ttccctgacc tgttgcggat   1860

gattgtgatg ggcaagaacc tggggatccc caagcctttt gggccccaaa tcaaggggac   1920

ctgctgcctg gaagaaaaga tttgctgctt gctggagccc ctgggcttca agtgcacctt   1980

catcaatgac tttgactgtt acctgacaga ggtcggagac atctgtgcct gtgccaacat   2040

ccgccgggtg ccctttgcct tcaaatggtg gaagatggta ccttagaccc aggccctgga   2100

gctgccagct c                                                        2111


<210>  5577
<211>  347
<212>  PRT
<213>  Homosapiens

<400>  5577

Met Val Ser Val Glu Gly Arg Ala Met Ser Phe Gln Ser Ile Ile His 
1               5                   10                  15      


Leu Ser Leu Asp Ser Pro Val His Ala Val Cys Val Leu Gly Thr Glu 
            20                  25                  30          


Ile Cys Leu Asp Leu Ser Gly Cys Ala Pro Gln Lys Cys Gln Cys Phe 
        35                  40                  45              


Thr Ile His Gly Ser Gly Arg Val Leu Ile Asp Val Ala Asn Thr Val 
    50                  55                  60                  


Ile Ser Glu Lys Glu Asp Ala Thr Ile Trp Trp Pro Leu Ser Asp Pro 
65                  70                  75                  80  


Thr Tyr Ala Thr Val Lys Met Thr Ser Pro Ser Pro Ser Val Asp Ala 
                85                  90                  95      


Asp Lys Val Ser Val Thr Tyr Tyr Gly Pro Asn Glu Asp Ala Pro Val 
            100                 105                 110         


Gly Thr Ala Val Leu Tyr Leu Thr Gly Ile Glu Val Ser Leu Glu Val 
        115                 120                 125             


Asp Ile Tyr Arg Asn Gly Gln Val Glu Met Ser Ser Asp Lys Gln Ala 
    130                 135                 140                 


Lys Lys Lys Trp Ile Trp Gly Pro Ser Gly Trp Gly Ala Ile Leu Leu 
145                 150                 155                 160 


Val Asn Cys Asn Pro Ala Asp Val Gly Gln Gln Leu Glu Asp Lys Lys 
                165                 170                 175     


Thr Lys Lys Val Ile Phe Ser Glu Glu Ile Thr Asn Leu Ser Gln Met 
            180                 185                 190         


Thr Leu Asn Val Gln Gly Pro Ser Cys Ile Leu Lys Lys Tyr Arg Leu 
        195                 200                 205             


Val Leu His Thr Ser Lys Glu Glu Ser Lys Lys Ala Arg Val Tyr Trp 
    210                 215                 220                 


Pro Gln Lys Asp Asn Ser Ser Thr Phe Glu Leu Val Leu Gly Pro Asp 
225                 230                 235                 240 


Gln His Ala Tyr Thr Leu Ala Leu Leu Gly Asn His Leu Lys Glu Thr 
                245                 250                 255     


Phe Tyr Val Glu Ala Ile Ala Phe Pro Ser Ala Glu Phe Ser Gly Leu 
            260                 265                 270         


Ile Ser Tyr Ser Val Ser Leu Val Glu Glu Ser Gln Asp Pro Ser Ile 
        275                 280                 285             


Pro Glu Thr Val Leu Tyr Lys Asp Thr Val Val Phe Arg Val Ala Pro 
    290                 295                 300                 


Cys Val Phe Ile Pro Cys Thr Gln Val Pro Leu Glu Val Tyr Leu Cys 
305                 310                 315                 320 


Arg Glu Leu Gln Leu Gln Gly Phe Val Asp Thr Val Thr Lys Leu Ser 
                325                 330                 335     


Glu Lys Ser Asn Ser Gln Gly Gly Ile Cys Leu 
            340                 345         


<210>  5578
<211>  1866
<212>  DNA
<213>  Homosapiens

<400>  5578
gtcatttcca tgtgcactgg gacgggaagt caaacgagga atttaaaaaa gcaaaagttg     60

accgaagatg ggcctaggcc ggtgtcggtt ctgtttctcc ccttggctgc ctgtacgccc    120

acagccttct ggctgcgaca ttatagaatc ggccgtgtcc cccctggtgg gggattgggg    180

atctgtgttt agccatttat atctacttta gctgttaaag aggtccaaat gaaaatcagg    240

tgattgtgga accatgggga cttgggggtg gggcagaggt gggaacattt gtatcagttg    300

agtcagcttg gtggctccct gtggagccag ggctgagcct tgtcacgcgc actcgccaat    360

taagagatgg accagccagc agtcaagtgc attctccagt ccttgcaaga aggatcagcc    420

ctttctgtgc cagcctcgat cgccttgtgc tttggtctct ttttctcccc cccgcctgga    480

tcctgcctcg cgcgggccgt cctgttgctg agactcgggg taccgttctg ctgacccagc    540

tccctttagt cacgtttgct tggctctggt accaaatagt tgggattacc gaagagtccc    600

cttccttgcg tgtcagcacg gatgctgtga ctgccacctg cgtcctcgtc aagtgcccga    660

gctcgccgcc gtgtgtgctg cgctgagtga gttatgaggt gcctttcccg gaaccctcct    720

ctcgcctgga cccaagagag gcgacagctg tggctggggc tcttggtttc cagagggtct    780

ggactggttt gggtgcttta aaatagatat ttagttcagt ggtgcttatg ggggagatgg    840

gactagaact taagtgtgag acttgggtgg atgggaaagt taaatattgg tctcttcaag    900

tttttttttt cttttgcttt gttaccactt gtcactgtct ccatgttaaa atgccaaaaa    960

tgatgtagtt gttgttgctt ttttccctat tttccacccc agtcgctcct taccgtgact   1020

cctgcccttg gagggcatgt agcagtgtct gtcctgccag tcccaaggcc ctgtgggagg   1080

agactggcct gcatctctct aagacttagt ctgacgccac gcgcatctct tgttctgtgt   1140

tcaatcagta gtccagggga gaagcttctg ctacttcaga gctttgctaa actaacctaa   1200

tttgtccaaa tcaccccaaa accaccatct ctgacgtaag cttccatgcg acagcctgat   1260

ccgtttccct ggacaggtct ctttcctgga atgcagccca ggcacctgtg ctcctggcac   1320

ccttgaggtc tctcctttga gccgtggtca ccgagagggt tgaggacgca gcacccgagg   1380

tcccagcctt tgcaggagcc tccctgggct tagctggact tagatcttcg gtggcctcat   1440

gtaaacgtgg cagccagcct cttctagaac cctagcccag ggactggagc aggaaaggga   1500

ccttcaaagt gaagactgcc ttgtcccgca gctccttctg gcttagattg aaaaatgggc   1560

ttcctaatgg gttaaatcct ttaaaacaag gagttgtggg ggaagggtgt cgtgcactcc   1620

tagagaaagg tacacagttg cccggttggg aatgtgcttg gcgctgaccc tgcgggcatc   1680

tgactggtct tccagctcag gaaaaagaat ttgaaagagg cttagcgtga aggggaatca   1740

aagaggaggt tgtgatttgg tcgaaggtgc ctggtttagt gctgtaattg tcttattatt   1800

ttttttatat atatatttct tggagtaaac attttaaata aacaacaaca ttgtctactg   1860

tcttgg                                                              1866


<210>  5579
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  5579

Met Cys Thr Gly Thr Gly Ser Gln Thr Arg Asn Leu Lys Lys Gln Lys 
1               5                   10                  15      


Leu Thr Glu Asp Gly Pro Arg Pro Val Ser Val Leu Phe Leu Pro Leu 
            20                  25                  30          


Ala Ala Cys Thr Pro Thr Ala Phe Trp Leu Arg His Tyr Arg Ile Gly 
        35                  40                  45              


Arg Val Pro Pro Gly Gly Gly Leu Gly Ile Cys Val 
    50                  55                  60  


<210>  5580
<211>  4091
<212>  DNA
<213>  Homosapiens

<400>  5580
cgcacatgtg tttctgtttt gtgttgtagc atttgttctg gaagctcgta tttacatttt     60

aagtgtatct ggtgagtggg ctggagccct cgtctgggcc ggaaaaaaaa aagccctccg    120

atccgtcttt tagttgcttc tcttcctttt ttctctccgg tttctcatca ctccaaccag    180

ccgcgaccat gcccaggaag aaggcggcgg cggcggcctg ggaggagccg agctcgggca    240

acggcactgc ccgcgccggg cccaggaaac gcggcggccc ggcgggcagg aagcgcgagc    300

ggcccgagcg ctgcagtagc agcagcggcg gcggcagcag cggcgacgag gacggcctgg    360

agctcgacgg ggcccccggc gggggcaagc gcgcggcgcg gccggcgaca gcaggcaagg    420

cgggcggcgc ggccgtggtc atcaccgaac ccgagcacac caaggagcgc gtcaaacttg    480

aagggtcaaa gtgcaaaggg cagcttttga tttttggggc aaccaactgg gacttgattg    540

gtcgaaaaga agtgcctaaa cagcaagctg cttaccgcaa tctcggtcag aatttgtggg    600

ggccccacag atatgggtgc ctggcggggg tccgggtgcg gacagtggtc tcgggctcgt    660

gtgctgcaca cagcctcctc atcaccacgg aagggaagct gtggagctgg ggtcgaaatg    720

agaaggggca gctgggacat ggtgacacca agagagtaga agcccctaga ctcatcgagg    780

gtcttagcca cgaagtgatt gtgtctgcag catgtgggcg gaaccacacc ttggccttga    840

cggaaacggg ctccgtgttt gcgtttgggg aaaacaagat ggggcagctg ggccttggca    900

accagacaga cgctgttccc agccccgcgc agataatgta caacggccag ccaattacca    960

aaatggcctg tggggctgaa ttcagtatga taatggactg caaaggaaac ctctattcct   1020

ttgggtgccc tgaatatggt cagctgggac acaactcaga tgggaagttc atcgcccggg   1080

cacagcggat agagtacgac tgtgaactag ttccccggcg agtggccatc ttcattgaga   1140

agacgaaaga tggacagatt ctgcctgtac caaacgtggt tgtacgagac gtggcctgtg   1200

gcgctaacca cacgctggtc ctggactccc agaagcgagt cttctcctgg ggctttggtg   1260

gctatggccg gctgggccac gcagagcaga aggatgagat ggtcccccgc ctggtgaagc   1320

tgtttgactt ccctgggcgt ggggcttccc agatctatgc tggttacacc tgctcctttg   1380

ctgtcagtga agtgggtggt ctgtttttct ggggggccac caacacctcc cgtgaatcta   1440

ccatgtaccc aaaagcagtg caggacctct gcggctggag aatccggagc ctggcttgtg   1500

ggaagagcag catcattgtg gccgccgatg agagcaccat cagctggggt ccgtcaccga   1560

cctttgggga actgggctac ggggaccaca agcccaagtc ttccactgca gcccaggagg   1620

taaagactct ggatggcatt ttctcagagc aggtcgccat gggctactca cactccttgg   1680

tgatagcaag agatgaaagt gagactgaga aagagaagat caagaaactg ccagaataca   1740

acccccgaac cctctgatgc tcccggagac tcctccgact ccacacctct cgcggcagct   1800

gtcatttcca tgtgcactgg gacgggaagt caaacgagga atttaaaaaa gcaaaagttg   1860

accgaaggtg catttttgtt tagactccct gaggttccgt tttacacatg atccaacgtt   1920

aactaccttt ttttctgtat gctttccaaa gtcctttttt ttcccttaat gttgaattaa   1980

aatacttgct catagttgat ttaccattcc tacaaaagag gcagaaactt tgagcaatct   2040

aggttttttt tttttttaag ttttttcttt cttcctctcc tgaatacact ccccaaaaca   2100

cccctttcca gttacaatta gcatcgtgat ccaagcagat gccacatgga agaggaatcg   2160

ccatttactc agaaaaaatg tcccttacag gaaccggcag cagctaggca gtcaccggcc   2220

cgcctccatc caaaatcacg ctcgcgtgct tcggaagcat ccgggtcact ccttctccgc   2280

tttttcttgc agatgggcct aggccggtgt cggttctgtt tctccccttg gctgcctgta   2340

cgcccacagc cttctggctg cgacattata gaatcggccg tgtcccccct ggtgggggat   2400

tggggatctg tgtttagcca tttatatcta ctttagctgt taaagaggtc caaatgaaaa   2460

tcaggtgatt gtggaaccat ggggacttgg gggtggggca gaggtgggaa catttgtatc   2520

agttgagtca gcttggtggc tccctgtgga gccagggctg agccttgtca cgcgcactcg   2580

ccaattaaga gatggaccag ccagcagtca agtgcattct ccagtccttg caagaaggat   2640

cagccctttc tgtgccagcc tcgatcgcct tgtgctttgg tctctttttc tcccccccgc   2700

ctggatcctg cctcgcgcgg gccgtcctgt tgctgagact cggggtaccg ttctgctgac   2760

ccagctccct ttagtcacgt ttgcttggct ctggtaccaa atagttggga ttaccgaaga   2820

gtccccttcc ttgcgtgtca gcacggatgc tgtgactgcc acctgcgtcc tcgtcaagtg   2880

cccgagctcg ccgccgtgtg tgctgcgctg agtgagttat gaggtgcctt tcccggaacc   2940

ctcctctcgc ctggacccaa gagaggcgac agctgtggct ggggctcttg gtttccagag   3000

ggtctggact ggtttgggtg ctttaaaata gatatttagt tcagtggtgc ttatggggga   3060

gatgggacta gaacttaagt gtgagacttg ggtggatggg aaagttaaat attggtctct   3120

tcaagttttt tttttctttt gctttgttac cacttgtcac tgtctccatg ttaaaatgcc   3180

aaaaatgatg tagttgttgt tgcttttttc cctattttcc accccagtcg ctccttaccg   3240

tgactcctgc ccttggaggg catgtagcag tgtctgtcct gccagtccca aggccctgtg   3300

ggaggagact ggcctgcatc tctctaagac ttagtctgac gccacgcgca tctcttgttc   3360

tgtgttcaat cagtagtcca ggggagaagc ttctgctact tcagagcttt gctaaactaa   3420

cctaatttgt ccaaatcacc ccaaaaccac catctctgac gtaagcttcc atgcgacagc   3480

ctgatccgtt tccctggaca ggtctctttc ctggaatgca gcccaggcac ctgtgctcct   3540

ggcacccttg aggtctctcc tttgagccgt ggtcaccgag agggttgagg acgcagcacc   3600

cgaggtccca gcctttgcag gagcctccct gggcttagct ggacttagat cttcggtggc   3660

ctcatgtaaa cgtggcagcc agcctcttct agaaccctag cccagggact ggagcaggaa   3720

agggaccttc aaagtgaaga ctgccttgtc ccgcagctcc ttctggctta gattgaaaaa   3780

tgggcttcct aatgggttaa atcctttaaa acaaggagtt gtgggggaag ggtgtcgtgc   3840

actcctagag aaaggtacac agttgcccgg ttgggaatgt gcttggcgct gaccctgcgg   3900

gcatctgact ggtcttccag ctcaggaaaa agaatttgaa agaggcttag cgtgaagggg   3960

aatcaaagag gaggttgtga tttggtcgaa ggtgcctggt ttagtgctgt aattgtctta   4020

ttattttttt tatatatata tttcttggag taaacatttt aaataaacaa caacattgtc   4080

tactgtcttg g                                                        4091


<210>  5581
<211>  522
<212>  PRT
<213>  Homosapiens

<400>  5581

Met Pro Arg Lys Lys Ala Ala Ala Ala Ala Trp Glu Glu Pro Ser Ser 
1               5                   10                  15      


Gly Asn Gly Thr Ala Arg Ala Gly Pro Arg Lys Arg Gly Gly Pro Ala 
            20                  25                  30          


Gly Arg Lys Arg Glu Arg Pro Glu Arg Cys Ser Ser Ser Ser Gly Gly 
        35                  40                  45              


Gly Ser Ser Gly Asp Glu Asp Gly Leu Glu Leu Asp Gly Ala Pro Gly 
    50                  55                  60                  


Gly Gly Lys Arg Ala Ala Arg Pro Ala Thr Ala Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Ala Ala Val Val Ile Thr Glu Pro Glu His Thr Lys Glu Arg Val Lys 
                85                  90                  95      


Leu Glu Gly Ser Lys Cys Lys Gly Gln Leu Leu Ile Phe Gly Ala Thr 
            100                 105                 110         


Asn Trp Asp Leu Ile Gly Arg Lys Glu Val Pro Lys Gln Gln Ala Ala 
        115                 120                 125             


Tyr Arg Asn Leu Gly Gln Asn Leu Trp Gly Pro His Arg Tyr Gly Cys 
    130                 135                 140                 


Leu Ala Gly Val Arg Val Arg Thr Val Val Ser Gly Ser Cys Ala Ala 
145                 150                 155                 160 


His Ser Leu Leu Ile Thr Thr Glu Gly Lys Leu Trp Ser Trp Gly Arg 
                165                 170                 175     


Asn Glu Lys Gly Gln Leu Gly His Gly Asp Thr Lys Arg Val Glu Ala 
            180                 185                 190         


Pro Arg Leu Ile Glu Gly Leu Ser His Glu Val Ile Val Ser Ala Ala 
        195                 200                 205             


Cys Gly Arg Asn His Thr Leu Ala Leu Thr Glu Thr Gly Ser Val Phe 
    210                 215                 220                 


Ala Phe Gly Glu Asn Lys Met Gly Gln Leu Gly Leu Gly Asn Gln Thr 
225                 230                 235                 240 


Asp Ala Val Pro Ser Pro Ala Gln Ile Met Tyr Asn Gly Gln Pro Ile 
                245                 250                 255     


Thr Lys Met Ala Cys Gly Ala Glu Phe Ser Met Ile Met Asp Cys Lys 
            260                 265                 270         


Gly Asn Leu Tyr Ser Phe Gly Cys Pro Glu Tyr Gly Gln Leu Gly His 
        275                 280                 285             


Asn Ser Asp Gly Lys Phe Ile Ala Arg Ala Gln Arg Ile Glu Tyr Asp 
    290                 295                 300                 


Cys Glu Leu Val Pro Arg Arg Val Ala Ile Phe Ile Glu Lys Thr Lys 
305                 310                 315                 320 


Asp Gly Gln Ile Leu Pro Val Pro Asn Val Val Val Arg Asp Val Ala 
                325                 330                 335     


Cys Gly Ala Asn His Thr Leu Val Leu Asp Ser Gln Lys Arg Val Phe 
            340                 345                 350         


Ser Trp Gly Phe Gly Gly Tyr Gly Arg Leu Gly His Ala Glu Gln Lys 
        355                 360                 365             


Asp Glu Met Val Pro Arg Leu Val Lys Leu Phe Asp Phe Pro Gly Arg 
    370                 375                 380                 


Gly Ala Ser Gln Ile Tyr Ala Gly Tyr Thr Cys Ser Phe Ala Val Ser 
385                 390                 395                 400 


Glu Val Gly Gly Leu Phe Phe Trp Gly Ala Thr Asn Thr Ser Arg Glu 
                405                 410                 415     


Ser Thr Met Tyr Pro Lys Ala Val Gln Asp Leu Cys Gly Trp Arg Ile 
            420                 425                 430         


Arg Ser Leu Ala Cys Gly Lys Ser Ser Ile Ile Val Ala Ala Asp Glu 
        435                 440                 445             


Ser Thr Ile Ser Trp Gly Pro Ser Pro Thr Phe Gly Glu Leu Gly Tyr 
    450                 455                 460                 


Gly Asp His Lys Pro Lys Ser Ser Thr Ala Ala Gln Glu Val Lys Thr 
465                 470                 475                 480 


Leu Asp Gly Ile Phe Ser Glu Gln Val Ala Met Gly Tyr Ser His Ser 
                485                 490                 495     


Leu Val Ile Ala Arg Asp Glu Ser Glu Thr Glu Lys Glu Lys Ile Lys 
            500                 505                 510         


Lys Leu Pro Glu Tyr Asn Pro Arg Thr Leu 
        515                 520         


<210>  5582
<211>  1200
<212>  DNA
<213>  Homosapiens

<400>  5582
ccgaagagtc cccttccttg cgtgtcagca cggatgctgt gactgccacc tgcgtcctcg     60

tcaagtgccc gagctcgccg ccgtgtgtgc tgcgctgagt gagttatgag gtgcctttcc    120

cggaaccctc ctctcgcctg gacccaagag aggcgacagc tgtggctggg gctcttggtt    180

tccagagggt ctggactggt ttgggtgctt taaaatagat atttagttca gtggtgctta    240

tgggggagat gggactagaa cttaagtgtg agacttgggt ggatgggaaa gttaaatatt    300

ggtctcttca agtttttttt ttcttttgct ttgttaccac ttgtcactgt ctccatgtta    360

aaatgccaaa aatgatgtag ttgttgttgc ttttttccct attttccacc ccagtcgctc    420

cttaccgtga ctcctgccct tggagggcat gtagcagtgt ctgtcctgcc agtcccaagg    480

ccctgtggga ggagactggc ctgcatctct ctaagactta gtctgacgcc acgcgcatct    540

cttgttctgt gttcaatcag tagtccaggg gagaagcttc tgctacttca gagctttgct    600

aaactaacct aatttgtcca aatcacccca aaaccaccat ctctgacgta agcttccatg    660

cgacagcctg atccgtttcc ctggacaggt ctctttcctg gaatgcagcc caggcacctg    720

tgctcctggc acccttgagg tctctccttt gagccgtggt caccgagagg gttgaggacg    780

cagcacccga ggtcccagcc tttgcaggag cctccctggg cttagctgga cttagatctt    840

cggtggcctc atgtaaacgt ggcagccagc tccttctggc ttagattgaa aaatgggctt    900

cctaatgggt taaatccttt aaaacaagga gttgtggggg aagggtgtcg tgcactccta    960

gagaaaggta cacagttgcc cggttgggaa tgtgcttggc gctgaccctg cgggcatctg   1020

actggtcttc cagctcagga aaaagaattt gaaagaggct tagcgtgaag gggaatcaaa   1080

gaggaggttg tgatttggtc gaaggtgcct ggtttagtgc tgtaattgtc ttattatttt   1140

ttttatatat atatttcttg gagtaaacat tttaaataaa caacaacatt gtctactgtc   1200


<210>  5583
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  5583

Met Gly Glu Met Gly Leu Glu Leu Lys Cys Glu Thr Trp Val Asp Gly 
1               5                   10                  15      


Lys Val Lys Tyr Trp Ser Leu Gln Val Phe Phe Phe Phe Cys Phe Val 
            20                  25                  30          


Thr Thr Cys His Cys Leu His Val Lys Met Pro Lys Met Met 
        35                  40                  45      


<210>  5584
<211>  1105
<212>  DNA
<213>  Homosapiens

<400>  5584
tgtgctttgg tctctttttc tcccccccgc ctggatcctg cctcgcgcgg gccgtcctgt     60

tgctgagact cggggtaccg ttctgctgac ccagctccct ttagtcacgt ttgcttggct    120

ctggtaccaa atagttggga ttaccgaaga gtccccttcc ttgcgtgtca gcacggatgc    180

tgtgactgcc acctgcgtcc tcgtcaagtg cccgagctcg ccgccgtgtg tgctgcgctg    240

agtgagttat gaggtgcctt tcccggaacc ctcctctcgc ctggacccaa gagaggcgac    300

agctgtggct ggggctcttg gtttccagag ggtctggact ggtttgggtg ctttaaaata    360

gatatttagt tcagtggtgc ttatggggga gatgggacta gaacttaagt gtgagacttg    420

ggtggatggg aaagttaaat attggtctct tcaagttttt tttttctttt gctttgttac    480

cacttgtcac tgtctccatg ttaaaatgcc aaaaatgatg tagttgttgt tgcttttttc    540

cctattttcc accccagtcg ctccttaccg tgactcctgc ccttggaggg catgtagcag    600

tgtctgtcct gccagtccca aggccctgtg ggaggagact ggcctgcatc tctctaagac    660

ttagtctgac gccacgcgca tctcttgttc tgtgttcaat cagtagtcca ggggagaagc    720

ttctgctact tcagagcttt gctaaactaa cctaatttgt ccaaatcacc ccaaaaccac    780

catctctgac gtaagcttcc atgcgacagc ctgatccgtt tccctggaca ggtctctttc    840

ctggaatgca gcccaggcac tcctagagaa aggtacacag ttgcccggtt gggaatgtgc    900

ttggcgctga ccctgcgggc atctgactgg tcttccagct caggaaaaag aatttgaaag    960

aggcttagcg tgaaggggaa tcaaagagga ggttgtgatt tggtcgaagg tgcctggttt   1020

agtgctgtaa ttgtcttatt atttttttta tatatatatt tcttggagta aacattttaa   1080

ataaacaaca acattgtcta ctgtc                                         1105


<210>  5585
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  5585

Met Gly Glu Met Gly Leu Glu Leu Lys Cys Glu Thr Trp Val Asp Gly 
1               5                   10                  15      


Lys Val Lys Tyr Trp Ser Leu Gln Val Phe Phe Phe Phe Cys Phe Val 
            20                  25                  30          


Thr Thr Cys His Cys Leu His Val Lys Met Pro Lys Met Met 
        35                  40                  45      


<210>  5586
<211>  1624
<212>  DNA
<213>  Homosapiens

<400>  5586
acattataga atcggccgtg tcccccctgg tgggggattg gggatctgtg tttagccatt     60

tatatctact ttagctgtta aagaggtcca aatgaaaatc aggtgattgt ggaaccatgg    120

ggacttgggg gtggggcaga ggtgggaaca tttgtatcag ttgagtcagc ttggtggctc    180

cctgtggagc cagggctgag ccttgtcacg cgcactcgcc aattaagaga tggaccagcc    240

agcagtcaag tgcattctcc agtccttgca agaaggatca gccctttctg tgccagcctc    300

gatcgccttg tgctttggtc tctttttctc ccccccgcct ggatcctgcc tcgcgcgggc    360

cgtcctgttg ctgagactcg gggtaccgtt ctgctgaccc agctcccttt agtcacgttt    420

gcttggctct ggtaccaaat agttgggatt accgaagagt ccccttcctt gcgtgtcagc    480

acggatgctg tgactgccac ctgcgtcctc gtcaagtgcc cgagctcgcc gccgtgtgtg    540

ctgcgctgag tgagttatga ggtgcctttc ccggaaccct cctctcgcct ggacccaaga    600

gaggcgacag ctgtggctgg ggctcttggt ttccagaggg tctggactgg tttgggtgct    660

ttaaaataga tatttagttc agtggtgctt atgggggaga tgggactaga acttaagtgt    720

gagacttggg tggatgggaa agttaaatat tggtctcttc aagttttttt tttcttttgc    780

tttgttacca cttgtcactg tctccatgtt aaaatgccaa aaatgatgta gttgttgttg    840

cttttttccc tattttccac cccagtcgct ccttaccgtg actcctgccc ttggagggca    900

tgtagcagtg tctgtcctgc cagtcccaag gccctgtggg aggagactgg cctgcatctc    960

tctaagactt agtctgacgc cacgcgcatc tcttgttctg tgttcaatca gtagtccagg   1020

ggagaagctt ctgctacttc agagctttgc taaactaacc taatttgtcc aaatcacccc   1080

aaaaccacca tctctgacgt aagcttccat gcgacagcct gatccgtttc cctggacagg   1140

tctctttcct ggaatgcagc ccaggcacct gtgctcctgg cacccttgag gtctctcctc   1200

atgtaaacgt ggcagccagc ctcttctaga accctagccc agggactgga gcaggaaagg   1260

gaccttcaaa gtgaagactg ccttgtcccg cagctccttc tggcttagat tgaaaaatgg   1320

gcttcctaat gggttaaatc ctttaaaaca aggagttgtg ggggaagggt gtcgtgcact   1380

cctagagaaa ggtacacagt tgcccggttg ggaatgtgct tggcgctgac cctgcgggca   1440

tctgactggt cttccagctc aggaaaaaga atttgaaaga ggcttagcgt gaaggggaat   1500

caaagaggag gttgtgattt ggtcgaaggt gcctggttta gtgctgtaat tgtcttatta   1560

ttttttttat atatatattt cttggagtaa acattttaaa taaacaacaa cattgtctac   1620

tgtc                                                                1624


<210>  5587
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  5587

Met Asp Gln Pro Ala Val Lys Cys Ile Leu Gln Ser Leu Gln Glu Gly 
1               5                   10                  15      


Ser Ala Leu Ser Val Pro Ala Ser Ile Ala Leu Cys Phe Gly Leu Phe 
            20                  25                  30          


Phe Ser Pro Pro Pro Gly Ser Cys Leu Ala Arg Ala Val Leu Leu Leu 
        35                  40                  45              


Arg Leu Gly Val Pro Phe Cys 
    50                  55  


<210>  5588
<211>  1240
<212>  DNA
<213>  Homosapiens

<400>  5588
acattataga atcggccgtg tcccccctgg tgggggattg gggatctgtg tttagccatt     60

tatatctact ttagctgtta aagaggtcca aatgaaaatc aggtgattgt ggaaccatgg    120

ggacttgggg gtggggcaga ggtgggaaca tttgtatcag ttgagtcagc ttggtggctc    180

cctgtggagc cagggctgag ccttgtcacg cgcactcgcc aattaagaga tggaccagcc    240

agcagtcaag tgcattctcc agtccttgca agaaggatca gccctttctg tgccagcctc    300

gatcgccttg tgctttggtc tctttttctc ccccccgcct ggatcctgcc tcgcgcgggc    360

cgtcctgttg ctgagactcg gggtaccgtt ctgctgaccc agctcccttt agtcacgttt    420

gcttggctct ggtaccaaat agttgggatt accgaagagt ccccttcctt gcgtgtcagc    480

acggatgctg tgactgccac ctgcgtcctc gtcaagtgcc cgagctcgcc gccgtgtgtg    540

ctgcgctgag tgagttatga ggtgcctttc ccggaaccct cctctcgcct ggacccaaga    600

gaggcgacag ctgtggctgg ggctcttggt ttccagaggg tctggactgg tttgggtgct    660

ttaaaataga tatttagttc agtggtgctt atgggggaga tgggactaga acttaagtgt    720

gagacttggg tggatgggaa agttaaatat tggtctcttc aagttttttt tttcttttgc    780

tttgttacca cttgtcactg tctccatgtt aaaatgccaa aaatgatgta gttgttgttg    840

cttttttccc tattttccac cccagtcgct ccttaccgtg actcctgccc ttggagggca    900

tgtagcagtg tctgtcctgc cagtcccaag gccctgtggg aggagactgg cctgcatctc    960

tctaagactt agtctgacgc cacgcgcatc tcttgttctg tgttcaatca gtagtccagg   1020

ggagaagctt ctgctacttc agagctttgc taaactaacc taatttgtcc aaatcacccc   1080

aaaaccacca tctctgacgt aagcttccat gcgacagcct gatccgtttc cctggacagg   1140

tctctttcct ggtttagtgc tgtaattgtc ttattatttt ttttatatat atatttcttg   1200

gagtaaacat tttaaataaa caacaacatt gtctactgtc                         1240


<210>  5589
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  5589

Met Asp Gln Pro Ala Val Lys Cys Ile Leu Gln Ser Leu Gln Glu Gly 
1               5                   10                  15      


Ser Ala Leu Ser Val Pro Ala Ser Ile Ala Leu Cys Phe Gly Leu Phe 
            20                  25                  30          


Phe Ser Pro Pro Pro Gly Ser Cys Leu Ala Arg Ala Val Leu Leu Leu 
        35                  40                  45              


Arg Leu Gly Val Pro Phe Cys 
    50                  55  


<210>  5590
<211>  1804
<212>  DNA
<213>  Homosapiens

<400>  5590
gatgccacat ggaagaggaa tcgccattta ctcagaaaaa atgtccctta caggaaccgg     60

cagcagctag gcagtcaccg gcccgcctcc atccaaaatc acgctcgcgt gcttcggaag    120

catccgggtc actccttctc cgctttttct tgcagatggg cctaggccgg tgtcggttct    180

gtttctcccc ttggctgcct gtacgcccac agccttctgg ctgcgacatt atagaatcgg    240

ccgtgtcccc cctggtgggg gattggggat ctgtgtttag ccatttatat ctactttagc    300

tgttaaagag gtccaaatga aaatcaggtg attgtggaac catggggact tgggggtggg    360

gcagaggtgg gaacatttgt atcagttgag tcagcttggt ggctccctgt ggagccaggg    420

ctgagccttg tcacgcgcac tcgccaatta agagatggac cagccagcag tcaagtgcat    480

tctccagtcc ttgcaagaag gatcagccct ttctgtgcca gcctcgatcg ccttgtgctt    540

tggtctcttt ttctcccccc cgcctggatc ctgcctcgcg cgggccgtcc tgttgctgag    600

actcggggta ccgttctgct gacccagctc cctttagtca cgtttgcttg gctctggtac    660

caaatagttg ggattaccga agagtcccct tccttgcgtg tcagcacgga tgctgtgact    720

gccacctgcg tcctcgtcaa gtgcccgagc tcgccgccgt gtgtgctgcg ctgagtgagt    780

tatgaggtgc ctttcccgga accctcctct cgcctggacc caagagaggc gacagctgtg    840

gctggggctc ttggtttcca gagggtctgg actggtttgg gtgctttaaa atagatattt    900

agttcagtgg tgcttatggg ggagatggga ctagaactta agtgtgagac ttgggtggat    960

gggaaagtta aatattggtc tcttcaagtt ttttttttct tttgctttgt taccacttgt   1020

cactgtctcc atgttaaaat gccaaaaatg atgtagttgt tgttgctttt ttccctattt   1080

tccaccccag tcgctcctta ccgtgactcc tgcccttgga gggcatgtag cagtgtctgt   1140

cctgccagtc ccaaggccct gtgggaggag actggcctgc atctctctaa gacttagtct   1200

gacgccacgc gcatctcttg ttctgtgttc aatcagtagt ccaggggaga agcttctgct   1260

acttcagagc tttgctaaac taacctaatt tgtccaaatc accccaaaac caccatctct   1320

gacgtaagct tccatgcgac agcctgatcc gtttccctgg attagatctt cggtggcctc   1380

atgtaaacgt ggcagccagc ctcttctaga accctagccc agggactgga gcaggaaagg   1440

gaccttcaaa gtgaagactg ccttgtcccg cagctccttc tggcttagat tgaaaaatgg   1500

gcttcctaat gggttaaatc ctttaaaaca aggagttgtg ggggaagggt gtcgtgcact   1560

cctagagaaa ggtacacagt tgcccggttg ggaatgtgct tggcgctgac cctgcgggca   1620

tctgactggt cttccagctc aggaaaaaga atttgaaaga ggcttagcgt gaaggggaat   1680

caaagaggag gttgtgattt ggtcgaaggt gcctggttta gtgctgtaat tgtcttatta   1740

ttttttttat atatatattt cttggagtaa acattttaaa taaacaacaa cattgtctac   1800

tgtc                                                                1804


<210>  5591
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  5591

Met Glu Glu Glu Ser Pro Phe Thr Gln Lys Lys Cys Pro Leu Gln Glu 
1               5                   10                  15      


Pro Ala Ala Ala Arg Gln Ser Pro Ala Arg Leu His Pro Lys Ser Arg 
            20                  25                  30          


Ser Arg Ala Ser Glu Ala Ser Gly Ser Leu Leu Leu Arg Phe Phe Leu 
        35                  40                  45              


Gln Met Gly Leu Gly Arg Cys Arg Phe Cys Phe Ser Pro Trp Leu Pro 
    50                  55                  60                  


Val Arg Pro Gln Pro Ser Gly Cys Asp Ile Ile Glu Ser Ala Val Ser 
65                  70                  75                  80  


Pro Leu Val Gly Asp Trp Gly Ser Val Phe Ser His Leu Tyr Leu Leu 
                85                  90                  95      


<210>  5592
<211>  1419
<212>  DNA
<213>  Homosapiens

<400>  5592
gatgccacat ggaagaggaa tcgccattta ctcagaaaaa atgtccctta caggaaccgg     60

cagcagctag gcagtcaccg gcccgcctcc atccaaaatc acgctcgcgt gcttcggaag    120

catccgggtc actccttctc cgctttttct tgcagatggg cctaggccgg tgtcggttct    180

gtttctcccc ttggctgcct gtacgcccac agccttctgg ctgcgacatt atagaatcgg    240

ccgtgtcccc cctggtgggg gattggggat ctgtgtttag ccatttatat ctactttagc    300

tgttaaagag gtccaaatga aaatcaggtg attgtggaac catggggact tgggggtggg    360

gcagaggtgg gaacatttgt atcagttgag tcagcttggt ggctccctgt ggagccaggg    420

ctgagccttg tcacgcgcac tcgccaatta agagatggac cagccagcag tcaagtgcat    480

tctccagtcc ttgcaagaag gatcagccct ttctgtgcca gcctcgatcg ccttgtgctt    540

tggtctcttt ttctcccccc cgcctggatc ctgcctcgcg cgggccgtcc tgttgctgag    600

actcggggta ccgttctgct gacccagctc cctttagtca cgtttgcttg gctctggtac    660

caaatagttg ggattaccga agagtcccct tccttgcgtg tcagcacgga tgctgtgact    720

gccacctgcg tcctcgtcaa gtgcccgagc tcgccgccgt gtgtgctgcg ctgagtgagt    780

tatgaggtgc ctttcccgga accctcctct cgcctggacc caagagaggc gacagctgtg    840

gctggggctc ttggtttcca gagggtctgg actggtttgg gtgctttaaa atagatattt    900

agttcagtgg tgcttatggg ggagatggga ctagaactta agtgtgagac ttgggtggat    960

gggaaagtta aatattggtc tcttcaagtt ttttttttct tttgctttgt taccacttgt   1020

cactgtctcc atgttaaaat gccaaaaatg atgtagttgt tgttgctttt ttccctattt   1080

tccaccccag tcgctcctta ccgtgactcc tgcccttgga gggcatgtag cagtgtctgt   1140

cctgccagtc ccaaggccct gtgggaggag actggcctgc atctctctaa gacttagtct   1200

gacgccacgc gcatctcttg ttctgtgttc aatcagtagt ccaggggaga agcttctgct   1260

acttcagagc tttgctaaac taacctaatt tgtccaaatc accccaaaac caccatctct   1320

gacgtgcctg gtttagtgct gtaattgtct tattattttt tttatatata tatttcttgg   1380

agtaaacatt ttaaataaac aacaacattg tctactgtc                          1419


<210>  5593
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  5593

Met Glu Glu Glu Ser Pro Phe Thr Gln Lys Lys Cys Pro Leu Gln Glu 
1               5                   10                  15      


Pro Ala Ala Ala Arg Gln Ser Pro Ala Arg Leu His Pro Lys Ser Arg 
            20                  25                  30          


Ser Arg Ala Ser Glu Ala Ser Gly Ser Leu Leu Leu Arg Phe Phe Leu 
        35                  40                  45              


Gln Met Gly Leu Gly Arg Cys Arg Phe Cys Phe Ser Pro Trp Leu Pro 
    50                  55                  60                  


Val Arg Pro Gln Pro Ser Gly Cys Asp Ile Ile Glu Ser Ala Val Ser 
65                  70                  75                  80  


Pro Leu Val Gly Asp Trp Gly Ser Val Phe Ser His Leu Tyr Leu Leu 
                85                  90                  95      


<210>  5594
<211>  2029
<212>  DNA
<213>  Homosapiens

<400>  5594
cccgtccatt gtgcgccgct gccccgtgtc tccctccagc cgcgaccatg cccaggaaga     60

aggcggcggc ggcggcctgg gaggagccga gctcgggcaa cggcactgcc cgcgccgggc    120

ccaggaaacg cggcggcccg gcgggcagga agcgcgagcg gcccgagcgc tgcagtagca    180

gcagcggcgg cggcagcagc ggcgacgagg acggcctgga gctcgacggg gcccccggcg    240

ggggcaagcg cgcggcgcgg ccggcgacag caggcaaggc gggcggcgcg gccgtggtca    300

tcaccgaacc cgagcacacc aaggagcgcg tcaaacttga agggtcaaag tgcaaagggc    360

agcttttgat ttttggggca accaactggg acttgattgg tcgaaaagaa gtgcctaaac    420

agcaagctgc ttaccgcaat ctcggtcaga atttgtgggg gccccacaga tatgggtgcc    480

tggcgggggt ccgggtgcgg acagtggtct cgggctcgtg tgctgcacac agcctcctca    540

tcaccacgga agggaagctg tggagctggg gtcgaaatga gaaggggcag ctgggacatg    600

gtgacaccaa gagagtagaa gcccctagac tcatcgaggg tcttagccac gaagtgattg    660

tgtctgcagc atgtgggcgg aaccacacct tggccttgac ggaaacgggc tccgtgtttg    720

cgtttgggga aaacaagatg gggcagctgg gccttggcaa ccagacagac gctgttccca    780

gccccgcgca gataatgtac aacggccagc caattaccaa aatggcctgt ggggctgaat    840

tcagtatgat aatggactgc aaaggaaacc tctattcctt tgggtgccct gaatatggtc    900

agctgggaca caactcagat gggaagttca tcgcccgggc acagcggata gagtacgact    960

gtgaactagt tccccggcga gtggccatct tcattgagaa gacgaaagat ggacagattc   1020

tgcctgtacc aaacgtggtt gtacgagacg tggcctgtgg cgctaaccac acgctggtcc   1080

tggactccca gaagcgagtc ttctcctggg gctttggtgg ctatggccgg ctgggccacg   1140

cagagcagaa ggatgagatg gtcccccgcc tggtgaagct gtttgacttc cctgggcgtg   1200

gggcttccca gatctatgct ggttacacct gctcctttgc tgtcagtgaa gtgggtggtc   1260

tgtttttctg gggggccacc aacacctccc gtgaatctac catgtaccca aaagcagtgc   1320

aggacctctg cggctggaga atccggagcc tggcttgtgg gaagagcagc atcattgtgg   1380

ccgccgatga gagcaccatc agctggggtc cgtcaccgac ctttggggaa ctgggctacg   1440

gggaccacaa gcccaagtct tccactgcag cccaggaggt aaagactctg gatggcattt   1500

tctcagagca ggtcgccatg ggctactcac actccttggt gatagcaaga gatgaaagtg   1560

agactgagaa agagaagatc aagaaactgc cagaatacaa cccccgaacc ctctgatgct   1620

cccggagact cctccgactc cacacctctc gcggcagctg tcatttccat gtgcactggg   1680

acgggaagtc aaacgaggaa tttaaaaaag caaaagttga ccgaaggtgc atttttgttt   1740

agactccctg aggttccgtt ttacacatga tccaacgtta actacctttt tttctgtatg   1800

ctttccaaag tccttttttt tcccttaatg ttgaattaaa atacttgctc atagttgatt   1860

taccattcct acaaaagagg cagaaacttt gagcaatcta ggtttttttt ttttttaagt   1920

tttttctttc ttcctctcct gaatacactc cccaaaacac ccctttccag ttacaattag   1980

catcgtgatc caagcagatg ccacatggaa gaggaatcgc catttactc               2029


<210>  5595
<211>  522
<212>  PRT
<213>  Homosapiens

<400>  5595

Met Pro Arg Lys Lys Ala Ala Ala Ala Ala Trp Glu Glu Pro Ser Ser 
1               5                   10                  15      


Gly Asn Gly Thr Ala Arg Ala Gly Pro Arg Lys Arg Gly Gly Pro Ala 
            20                  25                  30          


Gly Arg Lys Arg Glu Arg Pro Glu Arg Cys Ser Ser Ser Ser Gly Gly 
        35                  40                  45              


Gly Ser Ser Gly Asp Glu Asp Gly Leu Glu Leu Asp Gly Ala Pro Gly 
    50                  55                  60                  


Gly Gly Lys Arg Ala Ala Arg Pro Ala Thr Ala Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Ala Ala Val Val Ile Thr Glu Pro Glu His Thr Lys Glu Arg Val Lys 
                85                  90                  95      


Leu Glu Gly Ser Lys Cys Lys Gly Gln Leu Leu Ile Phe Gly Ala Thr 
            100                 105                 110         


Asn Trp Asp Leu Ile Gly Arg Lys Glu Val Pro Lys Gln Gln Ala Ala 
        115                 120                 125             


Tyr Arg Asn Leu Gly Gln Asn Leu Trp Gly Pro His Arg Tyr Gly Cys 
    130                 135                 140                 


Leu Ala Gly Val Arg Val Arg Thr Val Val Ser Gly Ser Cys Ala Ala 
145                 150                 155                 160 


His Ser Leu Leu Ile Thr Thr Glu Gly Lys Leu Trp Ser Trp Gly Arg 
                165                 170                 175     


Asn Glu Lys Gly Gln Leu Gly His Gly Asp Thr Lys Arg Val Glu Ala 
            180                 185                 190         


Pro Arg Leu Ile Glu Gly Leu Ser His Glu Val Ile Val Ser Ala Ala 
        195                 200                 205             


Cys Gly Arg Asn His Thr Leu Ala Leu Thr Glu Thr Gly Ser Val Phe 
    210                 215                 220                 


Ala Phe Gly Glu Asn Lys Met Gly Gln Leu Gly Leu Gly Asn Gln Thr 
225                 230                 235                 240 


Asp Ala Val Pro Ser Pro Ala Gln Ile Met Tyr Asn Gly Gln Pro Ile 
                245                 250                 255     


Thr Lys Met Ala Cys Gly Ala Glu Phe Ser Met Ile Met Asp Cys Lys 
            260                 265                 270         


Gly Asn Leu Tyr Ser Phe Gly Cys Pro Glu Tyr Gly Gln Leu Gly His 
        275                 280                 285             


Asn Ser Asp Gly Lys Phe Ile Ala Arg Ala Gln Arg Ile Glu Tyr Asp 
    290                 295                 300                 


Cys Glu Leu Val Pro Arg Arg Val Ala Ile Phe Ile Glu Lys Thr Lys 
305                 310                 315                 320 


Asp Gly Gln Ile Leu Pro Val Pro Asn Val Val Val Arg Asp Val Ala 
                325                 330                 335     


Cys Gly Ala Asn His Thr Leu Val Leu Asp Ser Gln Lys Arg Val Phe 
            340                 345                 350         


Ser Trp Gly Phe Gly Gly Tyr Gly Arg Leu Gly His Ala Glu Gln Lys 
        355                 360                 365             


Asp Glu Met Val Pro Arg Leu Val Lys Leu Phe Asp Phe Pro Gly Arg 
    370                 375                 380                 


Gly Ala Ser Gln Ile Tyr Ala Gly Tyr Thr Cys Ser Phe Ala Val Ser 
385                 390                 395                 400 


Glu Val Gly Gly Leu Phe Phe Trp Gly Ala Thr Asn Thr Ser Arg Glu 
                405                 410                 415     


Ser Thr Met Tyr Pro Lys Ala Val Gln Asp Leu Cys Gly Trp Arg Ile 
            420                 425                 430         


Arg Ser Leu Ala Cys Gly Lys Ser Ser Ile Ile Val Ala Ala Asp Glu 
        435                 440                 445             


Ser Thr Ile Ser Trp Gly Pro Ser Pro Thr Phe Gly Glu Leu Gly Tyr 
    450                 455                 460                 


Gly Asp His Lys Pro Lys Ser Ser Thr Ala Ala Gln Glu Val Lys Thr 
465                 470                 475                 480 


Leu Asp Gly Ile Phe Ser Glu Gln Val Ala Met Gly Tyr Ser His Ser 
                485                 490                 495     


Leu Val Ile Ala Arg Asp Glu Ser Glu Thr Glu Lys Glu Lys Ile Lys 
            500                 505                 510         


Lys Leu Pro Glu Tyr Asn Pro Arg Thr Leu 
        515                 520         


<210>  5596
<211>  2778
<212>  DNA
<213>  Homosapiens

<400>  5596
gtactcaccc tctgggctcc tgcctgctac ttcaactgac agacgggacc cttcccagta     60

gaagggggct gcccctgtca cttgtgctcc cttcccggag gactgcgatt ggactgcaca    120

ggattgaggt gtgtagctgg gacggtgctg gtctgagctg gaccttgtct gatggcttcc    180

tccaaccctc ctccacagcc tgccataggt accgtaccca gggcttcctg tccctctcat    240

cctttcttag aagggggccg ctgggggccg gcggagggcc ttgctctgga gcagcatggc    300

gccgggtggg aagtctgctc tgctggctgc tggccctgcc tgggccgcat cctctatctc    360

acgttccttg tctacaaaat agaagtaact ttctgctcac ggaggaggct ctgagcaagg    420

gtcaatcctt ttcctgtctc cctgagatcc gccggagagg tgaacacacg ggggtctcag    480

gctgaagctt ataaatcagg ggtgaggaac tgaggttgga ggagagggtt gcgccatagg    540

gtcaggccgt tgaacagtgg tagcattgcc gcatttagtg aaaaaaagag aaagtaaaag    600

aaaaatacag ccaggcatgg tgtctcatgc ctgtaatccc agcactttgg gaggccgagg    660

cgggcagatc acttgaggtc acgagttcgg gaccagcctg gccaacatgg tgaaatccca    720

tctctacaaa aatacaaaaa ttagctgggt atggtgtggc acttgtaatc tcagctactt    780

gagaggctga ggcaggagaa ttgcttgaac ctgggagatg gaggttgcag tgagccaaga    840

tcacaccact gcactccagc ctgggtgaca gagcaagact gtctcaaaaa aaaaaaaaaa    900

aaaaaaaaga aaagagaaaa agaaaaatac atacttatac taacaaaatt attcgtcgtt    960

tatctgaaat tcaagtctgt gtcctgtatg ttatttggca accctggcac tggggcctca   1020

gacactgcag gtggaatcca ggccccgcct gggaggaaat gggcccaggg ctgtttcacc   1080

caggcagcag cttcctgtcc tcttgtatca ctatgagaga ggcagaattg cagatggtaa   1140

tgagtgaggg ctttgtcctc agccccatct gagtttgaat cctgaccctg ccacttagac   1200

tgtggggctg gttaagtgac atgttgtctc tgtggcttag tttcatcatc agtaaacatg   1260

gggacaatga taccctctcc tgggctgttg caaggtttaa atatatgtca ggcgtgggca   1320

tggggtaatc aattgctcac tgacgggagt gcttatcatc gtgggtgtca gcaggacaga   1380

cagcgtgtgc catgccctgc acccctggga gagccaaatg atgcatctcc tcctccctga   1440

gcctcggggt tcttcttggg cggggggtgg ggagcagcac agcagacctg tcttccctgt   1500

ggcaatgggt ggcttcctag ggtccctcgc ctcctggact cgcttgtatt ttctcacaag   1560

gaccgggtct gtccaggaac atcagaggca tgagtgacca gctctggctg tgccaccttt   1620

gcaggctatt aggaagggct tccttcagct ctcagctgtg ctgggatggg cctcctgagt   1680

tttccttctg ataaggagca atgcctgatt gccgggggga ggatagaagg cggccttgga   1740

gacaagcaca tctcacctcc caattcatga ctgggatttg ggtcccagca tgcctggcct   1800

tgccccatcc cgcccctgct gccatgggca cctgttccct ttcctctccc caccaagagg   1860

cctgaacctg aacatgggga gtgagaaaaa aaaatttatg actaagtcaa ttctgttctg   1920

ttcagcaaac atttgacaaa tatttgttgt tccagctctt tctaatattg ctggctagta   1980

tcatctgggt gaacccagct ctttgccatt ttctcattct ctgagagctt cccattacct   2040

tcccaaatta aattcaaatt cctgagtagg ggattcccca cgcaccttgt caactgtcta   2100

atgaccttca ttcctgcgcg tgtcttcagc acccccgggg cacttggtgt ttgttctctg   2160

tctttgctgt ggcctctgcc tggaatccac gctttagttg gagcttgtca ggccttttct   2220

catcctttaa ggctcagtgc gagggcagcc tcatcctcgg agcccttcct gaagccccag   2280

agagccccag ccccttcctc ttggcaccgt ctcagtctct gaggtttttg gttttctcct   2340

gctggctctg tcctgtcagc ctcacagtga gctccggagg ggagctcaca gtcacccacc   2400

ccgaacccca ggactgtgtc ttacctttcc ttccccctcc ctgcccactg gatgctggga   2460

gctgctcact gcatgcatgg ataactgaag ctatttgtac tcttaaaggg aggaggtgca   2520

ggccaggcac agtggctcat gcctataatc ctagcacttt gagaaacctt gcttgagctc   2580

cagagtttga gaccagtctg gacaacagag tggaaccctg tctctacaaa aaatgaaaaa   2640

aaaaaaaaat agctgggcat ggtgatgcta cctgggagtc tgaagtagga ggatcacttg   2700

agcccaggag gttgaggctg cagtgagcca tgatcgcacc actgccctcc agcctgggtg   2760

acagagtgag cttcattt                                                 2778


<210>  5597
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  5597

Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala Ile Gly Thr Val Pro 
1               5                   10                  15      


Arg Ala Ser Cys Pro Ser His Pro Phe Leu Glu Gly Gly Arg Trp Gly 
            20                  25                  30          


Pro Ala Glu Gly Leu Ala Leu Glu Gln His Gly Ala Gly Trp Glu Val 
        35                  40                  45              


Cys Ser Ala Gly Cys Trp Pro Cys Leu Gly Arg Ile Leu Tyr Leu Thr 
    50                  55                  60                  


Phe Leu Val Tyr Lys Ile Glu Val Thr Phe Cys Ser Arg Arg Arg Leu 
65                  70                  75                  80  


<210>  5598
<211>  4493
<212>  DNA
<213>  Homosapiens

<400>  5598
gcgccgtccc ggccatgggc gcccgcggcg gcctgcggag ctggaggcgc ggcgccggcc     60

gccaggcgcc tttgtgagcg gcgcggacga caaaggcgcg ggcccgggca gccgaggtgt    120

gtagctggga cggtgctggt ctgagctgga ccttgtctga tggcttcctc caaccctcct    180

ccacagcctg ccataggaga tcagctggtt ccaggagtcc caggcccctc ctctgaggca    240

gaggacgacc caggagaggc gtttgagttt gatgacagtg atgatgaaga ggacaccagc    300

gcagccctgg gcgtccccag ccttgctcct gagagggaca cagacccccc actgatccac    360

ttggactcca tccctgtcac tgacccagac ccagcagctg ctccacccgg cacaggggtg    420

ccagcctggg tgagcaatgg ggatgcagcg gacgcagcct tctccggggc ccggcactcc    480

agctggaagc ggaagagttc ccgtcgcatt gaccggttca ctttccccgc cctggaagag    540

gatgtgattt atgacgacgt cccctgcgag agcccagatg cgcatcagcc cggggcagag    600

aggaacctgc tctacgagga tgcgcaccgg gctggggccc ctcggcaggc ggaggaccta    660

ggctggagct ccagtgagtt cgagagctac agcgaggact cgggggagga ggccaagccg    720

gaggtcgagg tcgagcccgc caagcaccga gtgtccttcc agcccaagct ttctccagac    780

ctgactaggc taaaggagag atacgccagg actaagagag acatcttggc tttgagagtt    840

ggggggagag acatgcagga gctgaagcac aagtacgatt gtaagatgac ccagctcatg    900

aaggccgcca agagcgggac caaggatggg ctggagaaga cacggatggc cgtgatgcgc    960

aaagtctcct tcctgcacag gaaggacgtc ctcggtgact cggaggagga ggacatgggg   1020

ctcctggagg tcagcgtttc ggacatcaag cccccagccc cagagctggg ccccatgcca   1080

gagggcctga gccctcagca ggtggtccgg aggcatatcc tgggctccat cgtgcagagc   1140

gaaggcagct acgtggagtc tctgaagcgg atactccagg actaccgcaa ccccctgatg   1200

gagatggagc ccaaggcgct gagcgcccgc aagtgccagg tggtgttctt ccgcgtgaag   1260

gagatcctgc actgccactc catgttccag atcgccctgt cctcccgcgt ggctgagtgg   1320

gattccaccg agaagatcgg ggacctcttc gtggcctcgt tttccaagtc catggtgcta   1380

gatgtgtaca gtgactacgt gaacaacttc accagtgcca tgtccatcat caagaaggcc   1440

tgcctcacca agcctgcctt cctcgagttc ctcaagcgac ggcaggtgtg cagcccagac   1500

cgtgtcaccc tctacgggct gatggtcaag cccatccaga ggttcccaca gttcatactc   1560

ctgcttcagg acatgctgaa gaacaccccc aggggccatc cggacaggct gtcgctgcag   1620

ctggccctca cagagctgga gacgctggct gagaagctga acgagcagaa gcggctggct   1680

gaccaggtgg ctgagatcca gcagctgacc aagagcgtca gtgaccgcag cagcctcaac   1740

aagctgttga cctcaggcca gcggcagctg ctcctgtgtg agacgttgac ggagaccgtg   1800

tacggtgacc gcgggcagct aattaagtcc aaggagcgtc gggtcttcct gctcaacgac   1860

atgcttgtct gtgccaacat caacttcaag cctgccaacc acaggggcca gctggagatc   1920

agcagcctgg tgcccctggg gcccaagtat gtggtgaagt ggaacacggc gctgccccag   1980

gtgcaggtgg tggaggtggg ccaggacggt ggcacctatg acaaggacaa tgtgctcatc   2040

cagcactcag gcgccaagaa ggcctctgcc tcagggcagg ctcagaataa ggtgtacctc   2100

ggccccccac gcctcttcca ggagctgcag gacctgcaga aggacctggc cgtggtggag   2160

cagatcacgc ttctcatcag cacgctgcac ggcacctacc agaacctgaa catgactgtg   2220

gctcaagact ggtgcctggc cctgcagagg ctgatgcggg tgaaggagga agagatccac   2280

tcggccaaca agtgccgtct caggctcctg cttcctggga aacccgacaa gtccggccgc   2340

cccattagct tcatggtggt tttcatcacc cccaaccccc tgagcaagat ttcctgggtc   2400

aacaggttac atttggccaa aatcggactc cgggaggaga accagccagg ctggctatgc   2460

ccggatgagg acaagaagag caaagcccca ttctggtgcc cgatcctggc ctgctgcatc   2520

cctgccttct cctcccgggc actcagcctg cagcttgggg ccctggtcca cagtcctgtc   2580

aactgtcccc tgctgggttt ctcagcagtc agcacctccc ttccacaggg ctacctctgg   2640

gtcgggggcg gacaggaagg cgcagggggc caggtggaaa tcttttcctt gaaccggccc   2700

tcgccccgca ccgtcaagtc cttcccactg gcagcccctg tgctctgcat ggagtatatc   2760

ccggagctgg aggaggaggc ggagagcaga gacgagagcc cgacagttgc tgacccctcg   2820

gccacggtgc atccaaccat ctgcctcggg ctccaggatg gcagcatcct cctctacagc   2880

agtgtggaca ctggcaccca gtgcctggtg agctgcagga gcccaggtct gcagcctgtg   2940

ctctgcctgc gacacagccc cttccacctg ctcgctggcc tgcaggatgg gacccttgct   3000

gcttaccctc ggaccagcgg aggtgtcctg tgggacctgg agagccctcc cgtgtgcctg   3060

actgtggggc ccgggcctgt ccgcaccctg ttgagcctgg aggatgccgt gtgggccagc   3120

tgtgggccct gggtcactgt cctggaagcc accaccctgc agcctcagca aagcttcgag   3180

gcgcaccagg acgaggcagt gagcgtgaca cacatggtga aggcgggcag cggcgtctgg   3240

atggccttct cctccggcac ctccatccgc ctcttccaca ctgagaccct ggagcatctg   3300

caagagatca acatcgccac caggaccacc ttcctcctgc caggccagaa gcacttgtgt   3360

gtcaccagcc tcctgatctg ccagggtctg ctctgggtgg gcactgacca gggtgtcatc   3420

gtcctgctgc ccgtgcctcg gctggaaggc atccccaaga tcacagggaa aggcatggtc   3480

tcactcaacg ggcactgtgg gcctgtggcc ttcctggctg tggctaccag catcctggcc   3540

cctgacatcc tgcggagtga ccaggaggag gctgaggggc cccgggctga ggaggacaag   3600

ccagacgggc aggcacacga gcccatgccc gatagccacg tgggccgaga gctgacccgc   3660

aagaagggca tcctcttgca gtaccgcctg cgctccaccg cacacctccc gggcccgctg   3720

ctctccatgc gggagccggc gcctgctgat ggcgcagctt tggagcacag cgaggaggac   3780

ggctccattt acgagatggc cgacgacccc gacatctggg tgcgcagccg gccctgcgcc   3840

cgcgacgccc accgcaagga gatttgctct gtggccatca tctccggcgg gcagggctac   3900

cgcaactttg gcagcgctct gggcagcagt gggaggcagg ccccgtgtgg ggagacggac   3960

agcaccctcc tcatctggca ggtgcccttg atgctatagc gcctcccctc tcccctcaga   4020

gggcacagct gcaggcctga ccaaggccac gcccggctct cgtgctctag gacctgcacg   4080

ggacttgtgg atgggcctgg actctccaga aactacttgg gcagagcaaa ggaaaacctc   4140

ttgttttaaa aaaatttttt tcagagtgtt ttggggagga gttttagggc ttggggagag   4200

ggaggacaca tctggaggaa atggccttct ttttaaaagc aaaaaacaca aaacctcaca   4260

actgcctggc aagcccagta tcacttgttt gggccctagc gggactccaa ggcagccaca   4320

cgcccctcct ggaagggtgt gtgcgtgtga gtgtgtgcga gtgtgtgggc tggtgtgtga   4380

atatctataa ataagtatat atggtgtata ttatatgtgt ataaataaag tctgtacata   4440

ttggagctct gggagatgct ggaataaaag acaagagtta catctggact tgg          4493


<210>  5599
<211>  1279
<212>  PRT
<213>  Homosapiens

<400>  5599

Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala Ile Gly Asp Gln Leu 
1               5                   10                  15      


Val Pro Gly Val Pro Gly Pro Ser Ser Glu Ala Glu Asp Asp Pro Gly 
            20                  25                  30          


Glu Ala Phe Glu Phe Asp Asp Ser Asp Asp Glu Glu Asp Thr Ser Ala 
        35                  40                  45              


Ala Leu Gly Val Pro Ser Leu Ala Pro Glu Arg Asp Thr Asp Pro Pro 
    50                  55                  60                  


Leu Ile His Leu Asp Ser Ile Pro Val Thr Asp Pro Asp Pro Ala Ala 
65                  70                  75                  80  


Ala Pro Pro Gly Thr Gly Val Pro Ala Trp Val Ser Asn Gly Asp Ala 
                85                  90                  95      


Ala Asp Ala Ala Phe Ser Gly Ala Arg His Ser Ser Trp Lys Arg Lys 
            100                 105                 110         


Ser Ser Arg Arg Ile Asp Arg Phe Thr Phe Pro Ala Leu Glu Glu Asp 
        115                 120                 125             


Val Ile Tyr Asp Asp Val Pro Cys Glu Ser Pro Asp Ala His Gln Pro 
    130                 135                 140                 


Gly Ala Glu Arg Asn Leu Leu Tyr Glu Asp Ala His Arg Ala Gly Ala 
145                 150                 155                 160 


Pro Arg Gln Ala Glu Asp Leu Gly Trp Ser Ser Ser Glu Phe Glu Ser 
                165                 170                 175     


Tyr Ser Glu Asp Ser Gly Glu Glu Ala Lys Pro Glu Val Glu Val Glu 
            180                 185                 190         


Pro Ala Lys His Arg Val Ser Phe Gln Pro Lys Leu Ser Pro Asp Leu 
        195                 200                 205             


Thr Arg Leu Lys Glu Arg Tyr Ala Arg Thr Lys Arg Asp Ile Leu Ala 
    210                 215                 220                 


Leu Arg Val Gly Gly Arg Asp Met Gln Glu Leu Lys His Lys Tyr Asp 
225                 230                 235                 240 


Cys Lys Met Thr Gln Leu Met Lys Ala Ala Lys Ser Gly Thr Lys Asp 
                245                 250                 255     


Gly Leu Glu Lys Thr Arg Met Ala Val Met Arg Lys Val Ser Phe Leu 
            260                 265                 270         


His Arg Lys Asp Val Leu Gly Asp Ser Glu Glu Glu Asp Met Gly Leu 
        275                 280                 285             


Leu Glu Val Ser Val Ser Asp Ile Lys Pro Pro Ala Pro Glu Leu Gly 
    290                 295                 300                 


Pro Met Pro Glu Gly Leu Ser Pro Gln Gln Val Val Arg Arg His Ile 
305                 310                 315                 320 


Leu Gly Ser Ile Val Gln Ser Glu Gly Ser Tyr Val Glu Ser Leu Lys 
                325                 330                 335     


Arg Ile Leu Gln Asp Tyr Arg Asn Pro Leu Met Glu Met Glu Pro Lys 
            340                 345                 350         


Ala Leu Ser Ala Arg Lys Cys Gln Val Val Phe Phe Arg Val Lys Glu 
        355                 360                 365             


Ile Leu His Cys His Ser Met Phe Gln Ile Ala Leu Ser Ser Arg Val 
    370                 375                 380                 


Ala Glu Trp Asp Ser Thr Glu Lys Ile Gly Asp Leu Phe Val Ala Ser 
385                 390                 395                 400 


Phe Ser Lys Ser Met Val Leu Asp Val Tyr Ser Asp Tyr Val Asn Asn 
                405                 410                 415     


Phe Thr Ser Ala Met Ser Ile Ile Lys Lys Ala Cys Leu Thr Lys Pro 
            420                 425                 430         


Ala Phe Leu Glu Phe Leu Lys Arg Arg Gln Val Cys Ser Pro Asp Arg 
        435                 440                 445             


Val Thr Leu Tyr Gly Leu Met Val Lys Pro Ile Gln Arg Phe Pro Gln 
    450                 455                 460                 


Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn Thr Pro Arg Gly His 
465                 470                 475                 480 


Pro Asp Arg Leu Ser Leu Gln Leu Ala Leu Thr Glu Leu Glu Thr Leu 
                485                 490                 495     


Ala Glu Lys Leu Asn Glu Gln Lys Arg Leu Ala Asp Gln Val Ala Glu 
            500                 505                 510         


Ile Gln Gln Leu Thr Lys Ser Val Ser Asp Arg Ser Ser Leu Asn Lys 
        515                 520                 525             


Leu Leu Thr Ser Gly Gln Arg Gln Leu Leu Leu Cys Glu Thr Leu Thr 
    530                 535                 540                 


Glu Thr Val Tyr Gly Asp Arg Gly Gln Leu Ile Lys Ser Lys Glu Arg 
545                 550                 555                 560 


Arg Val Phe Leu Leu Asn Asp Met Leu Val Cys Ala Asn Ile Asn Phe 
                565                 570                 575     


Lys Pro Ala Asn His Arg Gly Gln Leu Glu Ile Ser Ser Leu Val Pro 
            580                 585                 590         


Leu Gly Pro Lys Tyr Val Val Lys Trp Asn Thr Ala Leu Pro Gln Val 
        595                 600                 605             


Gln Val Val Glu Val Gly Gln Asp Gly Gly Thr Tyr Asp Lys Asp Asn 
    610                 615                 620                 


Val Leu Ile Gln His Ser Gly Ala Lys Lys Ala Ser Ala Ser Gly Gln 
625                 630                 635                 640 


Ala Gln Asn Lys Val Tyr Leu Gly Pro Pro Arg Leu Phe Gln Glu Leu 
                645                 650                 655     


Gln Asp Leu Gln Lys Asp Leu Ala Val Val Glu Gln Ile Thr Leu Leu 
            660                 665                 670         


Ile Ser Thr Leu His Gly Thr Tyr Gln Asn Leu Asn Met Thr Val Ala 
        675                 680                 685             


Gln Asp Trp Cys Leu Ala Leu Gln Arg Leu Met Arg Val Lys Glu Glu 
    690                 695                 700                 


Glu Ile His Ser Ala Asn Lys Cys Arg Leu Arg Leu Leu Leu Pro Gly 
705                 710                 715                 720 


Lys Pro Asp Lys Ser Gly Arg Pro Ile Ser Phe Met Val Val Phe Ile 
                725                 730                 735     


Thr Pro Asn Pro Leu Ser Lys Ile Ser Trp Val Asn Arg Leu His Leu 
            740                 745                 750         


Ala Lys Ile Gly Leu Arg Glu Glu Asn Gln Pro Gly Trp Leu Cys Pro 
        755                 760                 765             


Asp Glu Asp Lys Lys Ser Lys Ala Pro Phe Trp Cys Pro Ile Leu Ala 
    770                 775                 780                 


Cys Cys Ile Pro Ala Phe Ser Ser Arg Ala Leu Ser Leu Gln Leu Gly 
785                 790                 795                 800 


Ala Leu Val His Ser Pro Val Asn Cys Pro Leu Leu Gly Phe Ser Ala 
                805                 810                 815     


Val Ser Thr Ser Leu Pro Gln Gly Tyr Leu Trp Val Gly Gly Gly Gln 
            820                 825                 830         


Glu Gly Ala Gly Gly Gln Val Glu Ile Phe Ser Leu Asn Arg Pro Ser 
        835                 840                 845             


Pro Arg Thr Val Lys Ser Phe Pro Leu Ala Ala Pro Val Leu Cys Met 
    850                 855                 860                 


Glu Tyr Ile Pro Glu Leu Glu Glu Glu Ala Glu Ser Arg Asp Glu Ser 
865                 870                 875                 880 


Pro Thr Val Ala Asp Pro Ser Ala Thr Val His Pro Thr Ile Cys Leu 
                885                 890                 895     


Gly Leu Gln Asp Gly Ser Ile Leu Leu Tyr Ser Ser Val Asp Thr Gly 
            900                 905                 910         


Thr Gln Cys Leu Val Ser Cys Arg Ser Pro Gly Leu Gln Pro Val Leu 
        915                 920                 925             


Cys Leu Arg His Ser Pro Phe His Leu Leu Ala Gly Leu Gln Asp Gly 
    930                 935                 940                 


Thr Leu Ala Ala Tyr Pro Arg Thr Ser Gly Gly Val Leu Trp Asp Leu 
945                 950                 955                 960 


Glu Ser Pro Pro Val Cys Leu Thr Val Gly Pro Gly Pro Val Arg Thr 
                965                 970                 975     


Leu Leu Ser Leu Glu Asp Ala Val Trp Ala Ser Cys Gly Pro Trp Val 
            980                 985                 990         


Thr Val Leu Glu Ala Thr Thr Leu  Gln Pro Gln Gln Ser  Phe Glu Ala 
        995                 1000                 1005             


His Gln  Asp Glu Ala Val Ser  Val Thr His Met Val  Lys Ala Gly 
    1010                 1015                 1020             


Ser Gly  Val Trp Met Ala Phe  Ser Ser Gly Thr Ser  Ile Arg Leu 
    1025                 1030                 1035             


Phe His  Thr Glu Thr Leu Glu  His Leu Gln Glu Ile  Asn Ile Ala 
    1040                 1045                 1050             


Thr Arg  Thr Thr Phe Leu Leu  Pro Gly Gln Lys His  Leu Cys Val 
    1055                 1060                 1065             


Thr Ser  Leu Leu Ile Cys Gln  Gly Leu Leu Trp Val  Gly Thr Asp 
    1070                 1075                 1080             


Gln Gly  Val Ile Val Leu Leu  Pro Val Pro Arg Leu  Glu Gly Ile 
    1085                 1090                 1095             


Pro Lys  Ile Thr Gly Lys Gly  Met Val Ser Leu Asn  Gly His Cys 
    1100                 1105                 1110             


Gly Pro  Val Ala Phe Leu Ala  Val Ala Thr Ser Ile  Leu Ala Pro 
    1115                 1120                 1125             


Asp Ile  Leu Arg Ser Asp Gln  Glu Glu Ala Glu Gly  Pro Arg Ala 
    1130                 1135                 1140             


Glu Glu  Asp Lys Pro Asp Gly  Gln Ala His Glu Pro  Met Pro Asp 
    1145                 1150                 1155             


Ser His  Val Gly Arg Glu Leu  Thr Arg Lys Lys Gly  Ile Leu Leu 
    1160                 1165                 1170             


Gln Tyr  Arg Leu Arg Ser Thr  Ala His Leu Pro Gly  Pro Leu Leu 
    1175                 1180                 1185             


Ser Met  Arg Glu Pro Ala Pro  Ala Asp Gly Ala Ala  Leu Glu His 
    1190                 1195                 1200             


Ser Glu  Glu Asp Gly Ser Ile  Tyr Glu Met Ala Asp  Asp Pro Asp 
    1205                 1210                 1215             


Ile Trp  Val Arg Ser Arg Pro  Cys Ala Arg Asp Ala  His Arg Lys 
    1220                 1225                 1230             


Glu Ile  Cys Ser Val Ala Ile  Ile Ser Gly Gly Gln  Gly Tyr Arg 
    1235                 1240                 1245             


Asn Phe  Gly Ser Ala Leu Gly  Ser Ser Gly Arg Gln  Ala Pro Cys 
    1250                 1255                 1260             


Gly Glu  Thr Asp Ser Thr Leu  Leu Ile Trp Gln Val  Pro Leu Met 
    1265                 1270                 1275             


Leu 
    


<210>  5600
<211>  3565
<212>  DNA
<213>  Homosapiens

<400>  5600
gagatggagt ttcactcttg ttgctcaggc tggaatgcag tggcgtgatc tctgctcact     60

gcaacctcca cctcctgggt tcaagtgatt ctcctgcctc agcctctggg attacagtag    120

ctgggattac aggtgcctgc caccacacct ggctaatttt ttgtatttta gtagagatgg    180

ggtttcacta tgttggccag gctggtcttg aactgctgac ctcaggtggt ccacctgcct    240

cagcctctca aagtgctgga attacaatta tgagccactg tgactggcca taaattttat    300

acatatatat gtgtgtatat atatatataa taattttttt tttgagatgg agttttggct    360

cttgttgctc aggctggagt gcaatggcat gatctcggct cactacaacc tctgcctccc    420

acgcacgttc aagcgattct catgcctcag cctcccgagt agctgggact acaggcgtgc    480

accactactc ccggctaatt tttgtatttt tagtagagac ggggtttcac catgtgggcc    540

aggctggtct caaactcctg acctcaggtg atctgcccac ctcagcctcc caaagtgctg    600

ggattacagg cgtgagccac catgcccagc ctgtaaatta tattttataa agtaataaat    660

actcaatttt tttcctaatt attttattct attattacct gtgcttttgt ggttatttgc    720

tgctttgtgt gtgtgtgcgt tggggagtgt attagttctt tttcatactg ctattttcat    780

actgctatga agaaatacct gagactaggt aatttgtaaa gaaaaagaga tttaatggac    840

tcacagttcc acatggctgg ggaggtctca caatcatggt agaaggcgaa ggaggagcaa    900

aggcacattt tacatggtgg caggcgagag agcctgtgta agggaactgt cctttataaa    960

accttcaggt cttgggagac ttattcacta tcatgagaac agcatgggga aaacctgccc   1020

ctgtgattca attacctccc accacgtccc tcccatgaca tgcagggatt atgggagcta   1080

caattcaaga tgagatttgg gtggggacgc agccaaacca tatcaagggg tgtgagtgtg   1140

ggtgtgggtg tgtgtgtaat gtacgtagtg gtgtgctact gcatatctca actccattca   1200

gtgatgtcac attggcagct tgaaattggc cagagtgaga gtatttatat cacagaaatt   1260

ggcaaacact gcaaatcaga atcttttccc ctgaagagcc tgtttaccag cacaccactg   1320

ggaatccagc aatgagcaac tcagtccctc cctttgaact tacattttgg tgtgatggcg   1380

ctccaggact gatcttagtg tcctcattgc tgaggggcag ctgctgggca gggcctgctt   1440

tggtgataga ggttgtaaat tgccctcaaa tcacaggagc tctccattcc agcaagtgag   1500

ttgttaccat gcaccaggaa gagaggaaat gggacaagga ggaaattcag ttaattgaga   1560

gctgactttg ccattgagta accctattca ggatgactca ggcatctggg aggaaaagca   1620

gcagtggtgt ctgaggacag accgtggaca aattaagtag cttggggctt gtggagttgt   1680

gatgtccagg acatgggtgg ctagagctga cataggcaac agtgggcatg acctgtccat   1740

atggattcag gacctgcatg agagagtaga ggcatgaatt attgagagtt cagtctggct   1800

ctggtgtcag gtgaatcaaa agtctgcagg gcttgaaaca gagtagggga agcattgaac   1860

cttcctcaag tcaggaggca cagcatcatc tgggtgccag caaaggaaat ctgacaaacc   1920

tcacctgtca ggggccttgt gctgtgtgga tcaccctgct tccctaaaaa tctttgaggt   1980

ttcttggtag tttcctgctg tccctgaagc ttgctggtct tccagcccct gcatctgtgg   2040

ctggtggatt ctcaaaaaaa atccatgtta atatcaagca caaaacttaa ttgggaagag   2100

gggtctcctg ttctcccccc attgctaatt gataccagaa aagctgcttc tgtccttcat   2160

ttaggcagat aattgagaac ttgtttgctt aaaggcaact gattttgact ttatgcctat   2220

aggtgccaga tatttttcat gcatcaattc atttaatttc catgccgatc ctgcaagtac   2280

gtcctatttt ccgatcttat cgatgaggaa attgagtctc agagacttat ccaagggcac   2340

tgtgtttgta agtggcagga tttgaacccg gcaggccctg agatctttct gcagtcccgt   2400

gctcccctcc tttatgcggt tttccttttc cctttgagga ggggagggag agattcatca   2460

catgcctgga atctcagcac actttgcctt tcttagttcg gagttaatgt atgttttttt   2520

aattcagtgt tggcaaggcc cagtctggtc atagctgggt ttgttacctt gtggctcagg   2580

ggcaaggatg agaatagaat tctggtaccc acacgggctc cctaggcctg gtgtcaggaa   2640

agagctaata ctaatggctc ataattgcag agtggcaggc accttggtag tgcatggctc   2700

gtgggagctt tctcagttct cagctactcc aagaggtggg gtgcatcatt atctctgttt   2760

tgcctccatt gaacttgccc agggttgagc aaccaagagt tagaagcacc acattctgct   2820

cgccccggag tcctgcctct ccactcttgt gtctttcctt gagcagcgcc aaccctccca   2880

gggcctggcc cggctgtgcc tttgacagcc cctagcagca gtgcccatat gctatggaaa   2940

atggggaagg ataattgacc acttggccac aggcccaggg tctgcccacc tcttggttag   3000

agccagcact gagctccctg ccatggggtt catcttccca ctggcctgtt ggttgagagg   3060

atggtctcag accaggcccc aacaccacct tcttgcagat acatccccag tccagggcag   3120

tgcaggtggt ttgtgatggt gccagcccat gttggcatgt tgggcccaag atgaggtggc   3180

atttctgagt tttggaaccc ctctttctcc ttgagagcct ggccccagag tgccctcctc   3240

tctgtaaaag tcctggttct agtcgctggc tgattggtat gcatcccaga atcccggcca   3300

ttagcataca aggcgggagc cagctctcat tactcccctc tcttcattgt ttgaagtggg   3360

cagacttgga gtgagctttg gaaatgtggg ctttttattc aatttcccta gaaaaacaat   3420

ggttaaatta agtaggaaaa taacagtctc ccgaaattga agaaaaatat tcctgaacct   3480

agacattacc cacaaccttt gaatttcttt taaaacaggc atttgtttta ctttaagtta   3540

tacatgtatc gcatgaccac tgaag                                         3565


<210>  5601
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  5601

Met Ser Arg Thr Trp Val Ala Arg Ala Asp Ile Gly Asn Ser Gly His 
1               5                   10                  15      


Asp Leu Ser Ile Trp Ile Gln Asp Leu His Glu Arg Val Glu Ala 
            20                  25                  30      


<210>  5602
<211>  4599
<212>  DNA
<213>  Homosapiens

<400>  5602
attagaaatt tgggtgcttc ctcgcaccag cacatttcaa gtgctcaata gtcgcatgtg     60

gcccgtggct cccattttgg acagggcaga tacagagtgt ttctgtcatt gcagagcctt    120

ctctttgctg gtgctgctgt atgctggaga agatgcgggt gctagggctg gggcttggga    180

ggacaaagga ctggctgagg ggacagcagc tctgtcaggc ctgggttccc ccagcacctc    240

ggatgcccac ttccctcttc tgggcacgcg gtctccttac gtctcatgtt ctgcttagct    300

tgctacgctc gtgtccatgg atcccctccc cactgccaga ggaagctgcc tcttctttct    360

ggcaacttca gccttttctc cttttcccgg atggtggctc agtaagaaac ctggctgttt    420

cgggggaggc aagggacggg tccctcacct gggtttggcg gatgggatgg gggtgtgcac    480

acacctcctt tagttgctcc taaggtcatg ttcaacattc gtggagtgca tttttctgct    540

cagggagctt tcccagaccc ggaatgtttg gtgctcacag accctggcaa ggatcggtat    600

tgctgttcct cagttttgcc tggggaaatg gaggctcagt gacgttcagt gacgtgccca    660

gagtcatgcc attggcgggt ggcccagggc tccaggtctc cagcacccct cggccccctc    720

ctcaccaggt cacatcatct cctggattag aaatctgctc acatagtctg tcctgaaagg    780

aaaaaaatcg gttacagcct cctgttgccc ctaaagaggg agatccccgg gcatgaacgc    840

accttctcac ccccactgtc gtccttggcc tttgctcacg gacctgggag ggaagggtct    900

gggtggttct gatctctgca ggccgaggcc tggggaggcg ggtggccctc ggtagcaggc    960

atcccaggcc gtcccttccc tgatgagcct ctctaccttt gctcagatga cccagctcat   1020

gaaggccgcc aagagcggga ccaaggatgg gctggagaag acacggatgg ccgtgatgcg   1080

caaagtctcc ttcctgcaca ggaaggacgt cctcggtgac tcggaggagg aggacatggg   1140

gctcctggag gtcagcgttt cggacatcaa gcccccagcc ccagagctgg gccccatgcc   1200

agagggcctg agccctcagc aggtggtccg gaggcatatc ctgggctcca tcgtgcagag   1260

cgaaggcagc tacgtggagt ctctgaagcg gatactccag gactaccgca accccctgat   1320

ggagatggag cccaaggcgc tgagcgcccg caagtgccag gtggtgttct tccgcgtgaa   1380

ggagatcctg cactgccact ccatgttcca gatcgccctg tcctcccgcg tggctgagtg   1440

ggattccacc gagaagatcg gggacctctt cgtggcctcg ttttccaagt ccatggtgct   1500

agatgtgtac agtgactacg tgaacaactt caccagtgcc atgtccatca tcaagaaggc   1560

ctgcctcacc aagcctgcct tcctcgagtt cctcaagcga cggcaggtgt gcagcccaga   1620

ccgtgtcacc ctctacgggc tgatggtcaa gcccatccag aggttcccac agttcatact   1680

cctgcttcag gacatgctga agaacacccc caggggccat ccggacaggc tgtcgctgca   1740

gctggccctc acagagctgg agacgctggc tgagaagctg aacgagcaga agcggctggc   1800

tgaccaggtg gctgagatcc agcagctgac caagagcgtc agtgaccgca gcagcctcaa   1860

caagctgttg acctcaggcc agcggcagct gctcctgtgt gagacgttga cggagaccgt   1920

gtacggtgac cgcgggcagc taattaagtc caaggagcgt cgggtcttcc tgctcaacga   1980

catgcttgtc tgtgccaaca tcaacttcaa gggccagctg gagatcagca gcctggtgcc   2040

cctggggccc aagtatgtgg tgaagtggaa cacggcgctg ccccaggtgc aggtggtgga   2100

ggtgggccag gacggtggca cctatgacaa ggacaatgtg ctcatccagc actcaggcgc   2160

caagaaggcc tctgcctcag ggcaggctca gaataaggtg tacctcggcc ccccacgcct   2220

cttccaggag ctgcaggacc tgcagaagga cctggccgtg gtggagcaga tcacgcttct   2280

catcagcacg ctgcacggca cctaccagaa cctgaacatg actgtggctc aagactggtg   2340

cctggccctg cagaggctga tgcgggtgaa ggaggaagag atccactcgg ccaacaagtg   2400

ccgtctcagg ctcctgcttc ctgggaaacc cgacaagtcc ggccgcccca ttagcttcat   2460

ggtggttttc atcaccccca accccctgag caagatttcc tgggtcaaca ggttacattt   2520

ggccaaaatc ggactccggg aggagaacca gccaggctgg ctatgcccgg atgaggacaa   2580

gaagagcaaa gccccattct ggtgcccgat cctggcctgc tgcatccctg ccttctcctc   2640

ccgggcactc agcctgcagc ttggggccct ggtccacagt cctgtcaact gtcccctgct   2700

gggtttctca gcagtcagca cctcccttcc acagggctac ctctgggtcg ggggcggaca   2760

ggaaggcgca gggggccagg tggaaatctt ttccttgaac cggccctcgc cccgcaccgt   2820

caagtccttc ccactggcag cccctgtgct ctgcatggag tatatcccgg agctggagga   2880

ggaggcggag agcagagacg agagcccgac agttgctgac ccctcggcca cggtgcatcc   2940

aaccatctgc ctcgggctcc aggatggcag catcctcctc tacagcagtg tggacactgg   3000

cacccagtgc ctggtgagct gcaggagccc aggtctgcag cctgtgctct gcctgcgaca   3060

cagccccttc cacctgctcg ctggcctgca ggatgggacc cttgctgctt accctcggac   3120

cagcggaggt gtcctgtggg acctggagag ccctcccgtg tgcctgactg tggggcccgg   3180

gcctgtccgc accctgttga gcctggagga tgccgtgtgg gccagctgtg ggccctgggt   3240

cactgtcctg gaagccacca ccctgcagcc tcagcaaagc ttcgaggcgc accaggacga   3300

ggcagtgagc gtgacacaca tggtgaaggc gggcagcggc gtctggatgg ccttctcctc   3360

cggcacctcc atccgcctct tccacactga gaccctggag catctgcaag agatcaacat   3420

cgccaccagg accaccttcc tcctgccagg ccagaagcac ttgtgtgtca ccagcctcct   3480

gatctgccag ggtctgctct gggtgggcac tgaccagggt gtcatcgtcc tgctgcccgt   3540

gcctcggctg gaaggcatcc ccaagatcac agggaaaggc atggtctcac tcaacgggca   3600

ctgtgggcct gtggccttcc tggctgtggc taccagcatc ctggcccctg acatcctgcg   3660

gagtgaccag gaggaggctg aggggccccg ggctgaggag gacaagccag acgggcaggc   3720

acacgagccc atgcccgata gccacgtggg ccgagagctg acccgcaaga agggcatcct   3780

cttgcagtac cgcctgcgct ccaccgcaca cctcccgggc ccgctgctct ccatgcggga   3840

gccggcgcct gctgatggcg cagctttgga gcacagcgag gaggacggct ccatttacga   3900

gatggccgac gaccccgaca tctgggtgcg cagccggccc tgcgcccgcg acgcccaccg   3960

caaggagatt tgctctgtgg ccatcatctc cggcgggcag ggctaccgca actttggcag   4020

cgctctgggc agcagtggga ggcaggcccc gtgtggggag acggacagca ccctcctcat   4080

ctggcaggtg cccttgatgc tatagcgcct cccctctccc ctcagagggc acagctgcag   4140

gcctgaccaa ggccacgccc ggctctcgtg ctctaggacc tgcacgggac ttgtggatgg   4200

gcctggactc tccagaaact acttgggcag agcaaaggaa aacctcttgt tttaaaaaaa   4260

tttttttcag agtgttttgg ggaggagttt tagggcttgg ggagagggag gacacatctg   4320

gaggaaatgg ccttcttttt aaaagcaaaa aacacaaaac ctcacaactg cctggcaagc   4380

ccagtatcac ttgtttgggc cctagcggga ctccaaggca gccacacgcc cctcctggaa   4440

gggtgtgtgc gtgtgagtgt gtgcgagtgt gtgggctggt gtgtgaatat ctataaataa   4500

gtatatatgg tgtatattat atgtgtataa ataaagtctg tacatattgg agctctggga   4560

gatgctggaa taaaagacaa gagttacatc tggacttgg                          4599


<210>  5603
<211>  1040
<212>  PRT
<213>  Homosapiens

<400>  5603

Met Ser Leu Ser Thr Phe Ala Gln Met Thr Gln Leu Met Lys Ala Ala 
1               5                   10                  15      


Lys Ser Gly Thr Lys Asp Gly Leu Glu Lys Thr Arg Met Ala Val Met 
            20                  25                  30          


Arg Lys Val Ser Phe Leu His Arg Lys Asp Val Leu Gly Asp Ser Glu 
        35                  40                  45              


Glu Glu Asp Met Gly Leu Leu Glu Val Ser Val Ser Asp Ile Lys Pro 
    50                  55                  60                  


Pro Ala Pro Glu Leu Gly Pro Met Pro Glu Gly Leu Ser Pro Gln Gln 
65                  70                  75                  80  


Val Val Arg Arg His Ile Leu Gly Ser Ile Val Gln Ser Glu Gly Ser 
                85                  90                  95      


Tyr Val Glu Ser Leu Lys Arg Ile Leu Gln Asp Tyr Arg Asn Pro Leu 
            100                 105                 110         


Met Glu Met Glu Pro Lys Ala Leu Ser Ala Arg Lys Cys Gln Val Val 
        115                 120                 125             


Phe Phe Arg Val Lys Glu Ile Leu His Cys His Ser Met Phe Gln Ile 
    130                 135                 140                 


Ala Leu Ser Ser Arg Val Ala Glu Trp Asp Ser Thr Glu Lys Ile Gly 
145                 150                 155                 160 


Asp Leu Phe Val Ala Ser Phe Ser Lys Ser Met Val Leu Asp Val Tyr 
                165                 170                 175     


Ser Asp Tyr Val Asn Asn Phe Thr Ser Ala Met Ser Ile Ile Lys Lys 
            180                 185                 190         


Ala Cys Leu Thr Lys Pro Ala Phe Leu Glu Phe Leu Lys Arg Arg Gln 
        195                 200                 205             


Val Cys Ser Pro Asp Arg Val Thr Leu Tyr Gly Leu Met Val Lys Pro 
    210                 215                 220                 


Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln Asp Met Leu Lys 
225                 230                 235                 240 


Asn Thr Pro Arg Gly His Pro Asp Arg Leu Ser Leu Gln Leu Ala Leu 
                245                 250                 255     


Thr Glu Leu Glu Thr Leu Ala Glu Lys Leu Asn Glu Gln Lys Arg Leu 
            260                 265                 270         


Ala Asp Gln Val Ala Glu Ile Gln Gln Leu Thr Lys Ser Val Ser Asp 
        275                 280                 285             


Arg Ser Ser Leu Asn Lys Leu Leu Thr Ser Gly Gln Arg Gln Leu Leu 
    290                 295                 300                 


Leu Cys Glu Thr Leu Thr Glu Thr Val Tyr Gly Asp Arg Gly Gln Leu 
305                 310                 315                 320 


Ile Lys Ser Lys Glu Arg Arg Val Phe Leu Leu Asn Asp Met Leu Val 
                325                 330                 335     


Cys Ala Asn Ile Asn Phe Lys Gly Gln Leu Glu Ile Ser Ser Leu Val 
            340                 345                 350         


Pro Leu Gly Pro Lys Tyr Val Val Lys Trp Asn Thr Ala Leu Pro Gln 
        355                 360                 365             


Val Gln Val Val Glu Val Gly Gln Asp Gly Gly Thr Tyr Asp Lys Asp 
    370                 375                 380                 


Asn Val Leu Ile Gln His Ser Gly Ala Lys Lys Ala Ser Ala Ser Gly 
385                 390                 395                 400 


Gln Ala Gln Asn Lys Val Tyr Leu Gly Pro Pro Arg Leu Phe Gln Glu 
                405                 410                 415     


Leu Gln Asp Leu Gln Lys Asp Leu Ala Val Val Glu Gln Ile Thr Leu 
            420                 425                 430         


Leu Ile Ser Thr Leu His Gly Thr Tyr Gln Asn Leu Asn Met Thr Val 
        435                 440                 445             


Ala Gln Asp Trp Cys Leu Ala Leu Gln Arg Leu Met Arg Val Lys Glu 
    450                 455                 460                 


Glu Glu Ile His Ser Ala Asn Lys Cys Arg Leu Arg Leu Leu Leu Pro 
465                 470                 475                 480 


Gly Lys Pro Asp Lys Ser Gly Arg Pro Ile Ser Phe Met Val Val Phe 
                485                 490                 495     


Ile Thr Pro Asn Pro Leu Ser Lys Ile Ser Trp Val Asn Arg Leu His 
            500                 505                 510         


Leu Ala Lys Ile Gly Leu Arg Glu Glu Asn Gln Pro Gly Trp Leu Cys 
        515                 520                 525             


Pro Asp Glu Asp Lys Lys Ser Lys Ala Pro Phe Trp Cys Pro Ile Leu 
    530                 535                 540                 


Ala Cys Cys Ile Pro Ala Phe Ser Ser Arg Ala Leu Ser Leu Gln Leu 
545                 550                 555                 560 


Gly Ala Leu Val His Ser Pro Val Asn Cys Pro Leu Leu Gly Phe Ser 
                565                 570                 575     


Ala Val Ser Thr Ser Leu Pro Gln Gly Tyr Leu Trp Val Gly Gly Gly 
            580                 585                 590         


Gln Glu Gly Ala Gly Gly Gln Val Glu Ile Phe Ser Leu Asn Arg Pro 
        595                 600                 605             


Ser Pro Arg Thr Val Lys Ser Phe Pro Leu Ala Ala Pro Val Leu Cys 
    610                 615                 620                 


Met Glu Tyr Ile Pro Glu Leu Glu Glu Glu Ala Glu Ser Arg Asp Glu 
625                 630                 635                 640 


Ser Pro Thr Val Ala Asp Pro Ser Ala Thr Val His Pro Thr Ile Cys 
                645                 650                 655     


Leu Gly Leu Gln Asp Gly Ser Ile Leu Leu Tyr Ser Ser Val Asp Thr 
            660                 665                 670         


Gly Thr Gln Cys Leu Val Ser Cys Arg Ser Pro Gly Leu Gln Pro Val 
        675                 680                 685             


Leu Cys Leu Arg His Ser Pro Phe His Leu Leu Ala Gly Leu Gln Asp 
    690                 695                 700                 


Gly Thr Leu Ala Ala Tyr Pro Arg Thr Ser Gly Gly Val Leu Trp Asp 
705                 710                 715                 720 


Leu Glu Ser Pro Pro Val Cys Leu Thr Val Gly Pro Gly Pro Val Arg 
                725                 730                 735     


Thr Leu Leu Ser Leu Glu Asp Ala Val Trp Ala Ser Cys Gly Pro Trp 
            740                 745                 750         


Val Thr Val Leu Glu Ala Thr Thr Leu Gln Pro Gln Gln Ser Phe Glu 
        755                 760                 765             


Ala His Gln Asp Glu Ala Val Ser Val Thr His Met Val Lys Ala Gly 
    770                 775                 780                 


Ser Gly Val Trp Met Ala Phe Ser Ser Gly Thr Ser Ile Arg Leu Phe 
785                 790                 795                 800 


His Thr Glu Thr Leu Glu His Leu Gln Glu Ile Asn Ile Ala Thr Arg 
                805                 810                 815     


Thr Thr Phe Leu Leu Pro Gly Gln Lys His Leu Cys Val Thr Ser Leu 
            820                 825                 830         


Leu Ile Cys Gln Gly Leu Leu Trp Val Gly Thr Asp Gln Gly Val Ile 
        835                 840                 845             


Val Leu Leu Pro Val Pro Arg Leu Glu Gly Ile Pro Lys Ile Thr Gly 
    850                 855                 860                 


Lys Gly Met Val Ser Leu Asn Gly His Cys Gly Pro Val Ala Phe Leu 
865                 870                 875                 880 


Ala Val Ala Thr Ser Ile Leu Ala Pro Asp Ile Leu Arg Ser Asp Gln 
                885                 890                 895     


Glu Glu Ala Glu Gly Pro Arg Ala Glu Glu Asp Lys Pro Asp Gly Gln 
            900                 905                 910         


Ala His Glu Pro Met Pro Asp Ser His Val Gly Arg Glu Leu Thr Arg 
        915                 920                 925             


Lys Lys Gly Ile Leu Leu Gln Tyr Arg Leu Arg Ser Thr Ala His Leu 
    930                 935                 940                 


Pro Gly Pro Leu Leu Ser Met Arg Glu Pro Ala Pro Ala Asp Gly Ala 
945                 950                 955                 960 


Ala Leu Glu His Ser Glu Glu Asp Gly Ser Ile Tyr Glu Met Ala Asp 
                965                 970                 975     


Asp Pro Asp Ile Trp Val Arg Ser Arg Pro Cys Ala Arg Asp Ala His 
            980                 985                 990         


Arg Lys Glu Ile Cys Ser Val Ala  Ile Ile Ser Gly Gly  Gln Gly Tyr 
        995                 1000                 1005             


Arg Asn  Phe Gly Ser Ala Leu  Gly Ser Ser Gly Arg  Gln Ala Pro 
    1010                 1015                 1020             


Cys Gly  Glu Thr Asp Ser Thr  Leu Leu Ile Trp Gln  Val Pro Leu 
    1025                 1030                 1035             


Met Leu  
    1040 


<210>  5604
<211>  3481
<212>  DNA
<213>  Homosapiens

<400>  5604
attaatagcc gtggcagggc tcgaatcaca ggccaagaat gttacccagc agctcgtggg     60

ggaagaggaa gctgcgaggc aggctggggt gggtgcggag tgatgcccgg ggcgtgatgt    120

gggcccggca ggagggtctg caccaccccc acccccacgc cgtcatccgc tgtccctcct    180

cctcctcctc ctctgtctcc tgctcaggtg actcggagga ggaggacatg gggctcctgg    240

aggtcagcgt ttcggacatc aagcccccag ccccagagct gggccccatg ccagagggcc    300

tgagccctca gcaggtggtc cggaggcata tcctgggctc catcgtgcag agcgaaggca    360

gctacgtgga gtctctgaag cggatactcc aggactaccg caaccccctg atggagatgg    420

agcccaaggc gctgagcgcc cgcaagtgcc aggtggtgtt cttccgcgtg aaggagatcc    480

tgcactgcca ctccatgttc cagatcgccc tgtcctcccg cgtggctgag tgggattcca    540

ccgagaagat cggggacctc ttcgtggcct cggacatgct gaagaacacc cccaggggcc    600

atccggacag gctgtcgctg cagctggccc tcacagagct ggagacgctg gctgagaagc    660

tgaacgagca gaagcggctg gctgaccagg tggctgagat ccagcagctg accaagagcg    720

tcagtgaccg cagcagcctc aacaagctgt tgacctcagg ccagcggcag ctgctcctgt    780

gtgagacgtt gacggagacc gtgtacggtg accgcgggca gctaattaag tccaaggagc    840

gtcgggtctt cctgctcaac gacatgcttg tctgtgccaa catcaacttc aagggccagc    900

tggagatcag cagcctggtg cccctggggc ccaagtatgt ggtgaagtgg aacacggcgc    960

tgccccaggt gcaggtggtg gaggtgggcc aggacggtgg cacctatgac aaggacaatg   1020

tgctcatcca gcactcaggc gccaagaagg cctctgcctc agggcaggct cagaataagg   1080

tgtacctcgg ccccccacgc ctcttccagg agctgcagga cctgcagaag gacctggccg   1140

tggtggagca gatcacgctt ctcatcagca cgctgcacgg cacctaccag aacctgaaca   1200

tgactgtggc tcaagactgg tgcctggccc tgcagaggct gatgcgggtg aaggaggaag   1260

agatccactc ggccaacaag tgccgtctca ggctcctgct tcctgggaaa cccgacaagt   1320

ccggccgccc cattagcttc atggtggttt tcatcacccc caaccccctg agcaagattt   1380

cctgggtcaa caggttacat ttggccaaaa tcggactccg ggaggagaac cagccaggct   1440

ggctatgccc ggatgaggac aagaagagca aagccccatt ctggtgcccg atcctggcct   1500

gctgcatccc tgccttctcc tcccgggcac tcagcctgca gcttggggcc ctggtccaca   1560

gtcctgtcaa ctgtcccctg ctgggtttct cagcagtcag cacctccctt ccacagggct   1620

acctctgggt cgggggcgga caggaaggcg cagggggcca ggtggaaatc ttttccttga   1680

accggccctc gccccgcacc gtcaagtcct tcccactggc agcccctgtg ctctgcatgg   1740

agtatatccc ggagctggag gaggaggcgg agagcagaga cgagagcccg acagttgctg   1800

acccctcggc cacggtgcat ccaaccatct gcctcgggct ccaggatggc agcatcctcc   1860

tctacagcag tgtggacact ggcacccagt gcctggtgag ctgcaggagc ccaggtctgc   1920

agcctgtgct ctgcctgcga cacagcccct tccacctgct cgctggcctg caggatggga   1980

cccttgctgc ttaccctcgg accagcggag gtgtcctgtg ggacctggag agccctcccg   2040

tgtgcctgac tgtggggccc gggcctgtcc gcaccctgtt gagcctggag gatgccgtgt   2100

gggccagctg tgggccctgg gtcactgtcc tggaagccac caccctgcag cctcagcaaa   2160

gcttcgaggc gcaccaggac gaggcagtga gcgtgacaca catggtgaag gcgggcagcg   2220

gcgtctggat ggccttctcc tccggcacct ccatccgcct cttccacact gagaccctgg   2280

agcatctgca agagatcaac atcgccacca ggaccacctt cctcctgcca ggccagaagc   2340

acttgtgtgt caccagcctc ctgatctgcc agggtctgct ctgggtgggc actgaccagg   2400

gtgtcatcgt cctgctgccc gtgcctcggc tggaaggcat ccccaagatc acagggaaag   2460

gcatggtctc actcaacggg cactgtgggc ctgtggcctt cctggctgtg gctaccagca   2520

tcctggcccc tgacatcctg cggagtgacc aggaggaggc tgaggggccc cgggctgagg   2580

aggacaagcc agacgggcag gcacacgagc ccatgcccga tagccacgtg ggccgagagc   2640

tgacccgcaa gaagggcatc ctcttgcagt accgcctgcg ctccaccgca cacctcccgg   2700

gcccgctgct ctccatgcgg gagccggcgc ctgctgatgg cgcagctttg gagcacagcg   2760

aggaggacgg ctccatttac gagatggccg acgaccccga catctgggtg cgcagccggc   2820

cctgcgcccg cgacgcccac cgcaaggaga tttgctctgt ggccatcatc tccggcgggc   2880

agggctaccg caactttggc agcgctctgg gcagcagtgg gaggcaggcc ccgtgtgggg   2940

agacggacag caccctcctc atctggcagg tgcccttgat gctatagcgc ctcccctctc   3000

ccctcagagg gcacagctgc aggcctgacc aaggccacgc ccggctctcg tgctctagga   3060

cctgcacggg acttgtggat gggcctggac tctccagaaa ctacttgggc agagcaaagg   3120

aaaacctctt gttttaaaaa aatttttttc agagtgtttt ggggaggagt tttagggctt   3180

ggggagaggg aggacacatc tggaggaaat ggccttcttt ttaaaagcaa aaaacacaaa   3240

acctcacaac tgcctggcaa gcccagtatc acttgtttgg gccctagcgg gactccaagg   3300

cagccacacg cccctcctgg aagggtgtgt gcgtgtgagt gtgtgcgagt gtgtgggctg   3360

gtgtgtgaat atctataaat aagtatatat ggtgtatatt atatgtgtat aaataaagtc   3420

tgtacatatt ggagctctgg gagatgctgg aataaaagac aagagttaca tctggacttg   3480

g                                                                   3481


<210>  5605
<211>  982
<212>  PRT
<213>  Homosapiens

<400>  5605

Met Leu Pro Ser Ser Ser Trp Gly Lys Arg Lys Leu Arg Gly Arg Leu 
1               5                   10                  15      


Gly Trp Val Arg Ser Asp Ala Arg Gly Val Met Trp Ala Arg Gln Glu 
            20                  25                  30          


Gly Leu His His Pro His Pro His Ala Val Ile Arg Cys Pro Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Val Ser Cys Ser Gly Asp Ser Glu Glu Glu Asp Met 
    50                  55                  60                  


Gly Leu Leu Glu Val Ser Val Ser Asp Ile Lys Pro Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Gly Pro Met Pro Glu Gly Leu Ser Pro Gln Gln Val Val Arg Arg 
                85                  90                  95      


His Ile Leu Gly Ser Ile Val Gln Ser Glu Gly Ser Tyr Val Glu Ser 
            100                 105                 110         


Leu Lys Arg Ile Leu Gln Asp Tyr Arg Asn Pro Leu Met Glu Met Glu 
        115                 120                 125             


Pro Lys Ala Leu Ser Ala Arg Lys Cys Gln Val Val Phe Phe Arg Val 
    130                 135                 140                 


Lys Glu Ile Leu His Cys His Ser Met Phe Gln Ile Ala Leu Ser Ser 
145                 150                 155                 160 


Arg Val Ala Glu Trp Asp Ser Thr Glu Lys Ile Gly Asp Leu Phe Val 
                165                 170                 175     


Ala Ser Asp Met Leu Lys Asn Thr Pro Arg Gly His Pro Asp Arg Leu 
            180                 185                 190         


Ser Leu Gln Leu Ala Leu Thr Glu Leu Glu Thr Leu Ala Glu Lys Leu 
        195                 200                 205             


Asn Glu Gln Lys Arg Leu Ala Asp Gln Val Ala Glu Ile Gln Gln Leu 
    210                 215                 220                 


Thr Lys Ser Val Ser Asp Arg Ser Ser Leu Asn Lys Leu Leu Thr Ser 
225                 230                 235                 240 


Gly Gln Arg Gln Leu Leu Leu Cys Glu Thr Leu Thr Glu Thr Val Tyr 
                245                 250                 255     


Gly Asp Arg Gly Gln Leu Ile Lys Ser Lys Glu Arg Arg Val Phe Leu 
            260                 265                 270         


Leu Asn Asp Met Leu Val Cys Ala Asn Ile Asn Phe Lys Gly Gln Leu 
        275                 280                 285             


Glu Ile Ser Ser Leu Val Pro Leu Gly Pro Lys Tyr Val Val Lys Trp 
    290                 295                 300                 


Asn Thr Ala Leu Pro Gln Val Gln Val Val Glu Val Gly Gln Asp Gly 
305                 310                 315                 320 


Gly Thr Tyr Asp Lys Asp Asn Val Leu Ile Gln His Ser Gly Ala Lys 
                325                 330                 335     


Lys Ala Ser Ala Ser Gly Gln Ala Gln Asn Lys Val Tyr Leu Gly Pro 
            340                 345                 350         


Pro Arg Leu Phe Gln Glu Leu Gln Asp Leu Gln Lys Asp Leu Ala Val 
        355                 360                 365             


Val Glu Gln Ile Thr Leu Leu Ile Ser Thr Leu His Gly Thr Tyr Gln 
    370                 375                 380                 


Asn Leu Asn Met Thr Val Ala Gln Asp Trp Cys Leu Ala Leu Gln Arg 
385                 390                 395                 400 


Leu Met Arg Val Lys Glu Glu Glu Ile His Ser Ala Asn Lys Cys Arg 
                405                 410                 415     


Leu Arg Leu Leu Leu Pro Gly Lys Pro Asp Lys Ser Gly Arg Pro Ile 
            420                 425                 430         


Ser Phe Met Val Val Phe Ile Thr Pro Asn Pro Leu Ser Lys Ile Ser 
        435                 440                 445             


Trp Val Asn Arg Leu His Leu Ala Lys Ile Gly Leu Arg Glu Glu Asn 
    450                 455                 460                 


Gln Pro Gly Trp Leu Cys Pro Asp Glu Asp Lys Lys Ser Lys Ala Pro 
465                 470                 475                 480 


Phe Trp Cys Pro Ile Leu Ala Cys Cys Ile Pro Ala Phe Ser Ser Arg 
                485                 490                 495     


Ala Leu Ser Leu Gln Leu Gly Ala Leu Val His Ser Pro Val Asn Cys 
            500                 505                 510         


Pro Leu Leu Gly Phe Ser Ala Val Ser Thr Ser Leu Pro Gln Gly Tyr 
        515                 520                 525             


Leu Trp Val Gly Gly Gly Gln Glu Gly Ala Gly Gly Gln Val Glu Ile 
    530                 535                 540                 


Phe Ser Leu Asn Arg Pro Ser Pro Arg Thr Val Lys Ser Phe Pro Leu 
545                 550                 555                 560 


Ala Ala Pro Val Leu Cys Met Glu Tyr Ile Pro Glu Leu Glu Glu Glu 
                565                 570                 575     


Ala Glu Ser Arg Asp Glu Ser Pro Thr Val Ala Asp Pro Ser Ala Thr 
            580                 585                 590         


Val His Pro Thr Ile Cys Leu Gly Leu Gln Asp Gly Ser Ile Leu Leu 
        595                 600                 605             


Tyr Ser Ser Val Asp Thr Gly Thr Gln Cys Leu Val Ser Cys Arg Ser 
    610                 615                 620                 


Pro Gly Leu Gln Pro Val Leu Cys Leu Arg His Ser Pro Phe His Leu 
625                 630                 635                 640 


Leu Ala Gly Leu Gln Asp Gly Thr Leu Ala Ala Tyr Pro Arg Thr Ser 
                645                 650                 655     


Gly Gly Val Leu Trp Asp Leu Glu Ser Pro Pro Val Cys Leu Thr Val 
            660                 665                 670         


Gly Pro Gly Pro Val Arg Thr Leu Leu Ser Leu Glu Asp Ala Val Trp 
        675                 680                 685             


Ala Ser Cys Gly Pro Trp Val Thr Val Leu Glu Ala Thr Thr Leu Gln 
    690                 695                 700                 


Pro Gln Gln Ser Phe Glu Ala His Gln Asp Glu Ala Val Ser Val Thr 
705                 710                 715                 720 


His Met Val Lys Ala Gly Ser Gly Val Trp Met Ala Phe Ser Ser Gly 
                725                 730                 735     


Thr Ser Ile Arg Leu Phe His Thr Glu Thr Leu Glu His Leu Gln Glu 
            740                 745                 750         


Ile Asn Ile Ala Thr Arg Thr Thr Phe Leu Leu Pro Gly Gln Lys His 
        755                 760                 765             


Leu Cys Val Thr Ser Leu Leu Ile Cys Gln Gly Leu Leu Trp Val Gly 
    770                 775                 780                 


Thr Asp Gln Gly Val Ile Val Leu Leu Pro Val Pro Arg Leu Glu Gly 
785                 790                 795                 800 


Ile Pro Lys Ile Thr Gly Lys Gly Met Val Ser Leu Asn Gly His Cys 
                805                 810                 815     


Gly Pro Val Ala Phe Leu Ala Val Ala Thr Ser Ile Leu Ala Pro Asp 
            820                 825                 830         


Ile Leu Arg Ser Asp Gln Glu Glu Ala Glu Gly Pro Arg Ala Glu Glu 
        835                 840                 845             


Asp Lys Pro Asp Gly Gln Ala His Glu Pro Met Pro Asp Ser His Val 
    850                 855                 860                 


Gly Arg Glu Leu Thr Arg Lys Lys Gly Ile Leu Leu Gln Tyr Arg Leu 
865                 870                 875                 880 


Arg Ser Thr Ala His Leu Pro Gly Pro Leu Leu Ser Met Arg Glu Pro 
                885                 890                 895     


Ala Pro Ala Asp Gly Ala Ala Leu Glu His Ser Glu Glu Asp Gly Ser 
            900                 905                 910         


Ile Tyr Glu Met Ala Asp Asp Pro Asp Ile Trp Val Arg Ser Arg Pro 
        915                 920                 925             


Cys Ala Arg Asp Ala His Arg Lys Glu Ile Cys Ser Val Ala Ile Ile 
    930                 935                 940                 


Ser Gly Gly Gln Gly Tyr Arg Asn Phe Gly Ser Ala Leu Gly Ser Ser 
945                 950                 955                 960 


Gly Arg Gln Ala Pro Cys Gly Glu Thr Asp Ser Thr Leu Leu Ile Trp 
                965                 970                 975     


Gln Val Pro Leu Met Leu 
            980         


<210>  5606
<211>  3584
<212>  DNA
<213>  Homosapiens

<400>  5606
cgagaagtgc ttccaagcgt ccattttgag ccttggaaac tacgacgacc aaagggccac     60

gggttcatgg gtcgtttctc atttccgtcg agttaaacgt ctggggctgc ttctgaggaa    120

tcagcttgac tggccagcaa gttcagctcc ggcaagtcat ttgattcacc cggtgatgaa    180

atgggggtca accagtctgt gggctttcca cctgtcacag gaccccacct cgtaggctgt    240

ggggatgtga tggagggtca gaatctccag gggagcttct ttcgactctt ctacccctgc    300

caaaaggcag aggagaccat ggagcagccc ctgtggattc cccgctatga gtactgcact    360

ggcctggccg agtacctgca gtttaataag cgctgcgggg gcttgctgtt caacctggcg    420

gtgggatctt gtcgcctgcc tgttagctgg aatggcccct ttaagacaaa ggactctgga    480

taccccttga tcatcttctc ccatggccta ggagccttca ggactttgta ttcagccttc    540

tgcatggagc tggcctcacg tggctttgtg gttgctgtgc cagagcacag ggaccggtca    600

gcggcaacca cctatttctg caagcaggcc ccagaagaga accagcccac caatgaatcg    660

ctgcaggagg aatggatccc tttccgtcga gttgaggaag gggagaagga atttcatgtt    720

cggaatcccc aggtgcatca gcgggtaagc gagtgtttac gggtgttgaa gatcctgcaa    780

gaggtcactg ctgggcagac tgtcttcaac atcttgcctg gtggcttgga tctgatgact    840

ttgaagggca acattgacat gagccgtgtg gctgtgatgg gacattcatt tggaggggcc    900

acagctattc tggctttggc caaggagacc caatttcggt gtgcggtggc tctggatgct    960

tggatgtttc ctctggaacg tgacttttac cccaaggccc gaggacctgt gttctttatc   1020

aatactgaga aattccagac aatggagagt gtcaatttga tgaagaagat atgtgcccag   1080

catgaacagt ctaggatcat aaccgttctt ggttctgttc atcggagtca aactgacttt   1140

gcttttgtga ctggcaactt gattggtaaa ttcttctcca ctgaaacccg tgggagcctg   1200

gacccctatg aagggcagga ggttatggta cgggccatgt tggccttcct gcagaagcac   1260

ctcgacctga aagaagacta taatcaatgg aacaacctta ttgaaggcat tggaccgtcg   1320

ctcaccccag gggcccccca ccatctgtcc agcctgtagg cacaactggc catttgtaaa   1380

gtcacttcag ccaagttttc atttgggagc tacccaaggg cacccatgag ctcctatcaa   1440

gaagtgatca acgtgacccc ttttcacaga ttgaaaggtg taatcacact gctgcttgga   1500

taactgggta ctttgatctt agatttgatc ttaaaatcac tttgggactg ggatcccttg   1560

ctgattgaca aacagacttt ctgggacctt gatggagtgg ggaacaagca gtagagtggg   1620

actgggggag acccaggccc cgggctgagc actgtgaggc ctggatgtga agactcagcc   1680

cagcgaagct cattccctta cccccggcca gtgctgctgc ttcagtggaa gagatgaagc   1740

caaaggacag aatgaaaatc cctaccttca gagactctag cccagcccaa caccatctct   1800

tcctacctct cagccttctc cctccccagg gccacttgtt gaagtctgag cactttatgt   1860

aaatttctag gtgtgagccg tgatcacatt ttctatttat ttccaagtct tctcattgta   1920

tggaacatag tactacttat acttacagta gtaagttata cttgtgagcc cacagagtgg   1980

cagacagcat ggctctcaca gcacagggag aaaaactgag gtacacagag gtacctcaga   2040

agctctggat gtctttgggg gttttgctaa gtgtatcttg ataggaaaca acaaaagcag   2100

gttgagatgg ggaagatgac agaacaacag tgttaaatgg ccatttgcac aggcctttgc   2160

cacaacagag aagtagtttg gtcagctaaa actcagctgc agcctggaca gtagagcgag   2220

accccatctt aaaaataaag aaggctgggc gtggtggctc atgcctgtaa tcccaacact   2280

ttgggaggcc aaggcaggca gatcacttaa ggccaggagt tcaagaccac ctggccaaca   2340

tggtgaaacc ccgtctctac taaaaataca aaaaattagc ctggcgtaat ggcaggcgcc   2400

tataatccca gctactcagg aggctgaagc agaagaatca cttgaaccta ggaggcggag   2460

gttgcagtga gtcaagatcg cgccactgca ctccagcctg ggtgacagag caagactctg   2520

tcttaaaaaa aaaaaaaaga aaaagaaaaa tttaaaataa ataaaattta aaaacgcaga   2580

aggccactcc cagagaggcc taggagtacc ttggtcattt tttcttgcct caaatattat   2640

aaacctccaa cttgctcaga atcagggtgc ttttattgtc tgttttctgg ctctgaggcc   2700

cttgccccaa atttaagtca gatacagact gaatttccat tctgttctgt ttataatatg   2760

aatgatatta atactcttgt ttgcttaatg ttatgttgga attttctgtt taatctgcag   2820

tagagcaaga tggagagcca tctggaattg acttccttct gtctttcttc tgtgttcgct   2880

tactacttgg gcccatgtgg gaaaaaaact ttaaaaggaa ggaagtcttc ttagggatcc   2940

agttcaaagc tatttggggg catcaaactg aaactctctt ctccactact caagacttcg   3000

tgcctcagtc caagtaggta agagcaaaag ggaaatgcat ctctacacaa tggcccatgg   3060

tcagggccac cagagcaagc tgggcctaga tctccacctg tcagtgactg gccattctaa   3120

gaggtgaaac agcagatcgt tgaggctgtg agggaggatc tttgaattcc catgagacat   3180

agcataagaa gggtatcatt aaagccctgg gctctaaagt tacagagcct ggttttgagt   3240

cctggctcca ccactgccaa ctgggtaaat ttgagcaaat ggtattctct ttcttatctc   3300

agctcctgcg tttctaaaat gagggtctgc gttatgaata gttaggagga ttaagtgaga   3360

ggatgtataa cccatgggtt acttaaaagt atatttccta ccttccaaac atgagatttt   3420

tctagttata gtttcttttc tagcttgatt gctttgtggt cagagaaaat gacccatatg   3480

gtttccatcc ttcaaaattt gttgaaactt ggttgttggc ctagtatgag atcaatgttg   3540

taaatgtgcc atgtatgttt aaaaagacta tatattctga agaa                    3584


<210>  5607
<211>  392
<212>  PRT
<213>  Homosapiens

<400>  5607

Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His 
1               5                   10                  15      


Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser 
            20                  25                  30          


Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu 
        35                  40                  45              


Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu 
    50                  55                  60                  


Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala 
65                  70                  75                  80  


Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr 
                85                  90                  95      


Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala 
            100                 105                 110         


Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly 
        115                 120                 125             


Phe Val Val Ala Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr 
    130                 135                 140                 


Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro Thr Asn Glu Ser 
145                 150                 155                 160 


Leu Gln Glu Glu Trp Ile Pro Phe Arg Arg Val Glu Glu Gly Glu Lys 
                165                 170                 175     


Glu Phe His Val Arg Asn Pro Gln Val His Gln Arg Val Ser Glu Cys 
            180                 185                 190         


Leu Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala Gly Gln Thr Val 
        195                 200                 205             


Phe Asn Ile Leu Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Asn 
    210                 215                 220                 


Ile Asp Met Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala 
225                 230                 235                 240 


Thr Ala Ile Leu Ala Leu Ala Lys Glu Thr Gln Phe Arg Cys Ala Val 
                245                 250                 255     


Ala Leu Asp Ala Trp Met Phe Pro Leu Glu Arg Asp Phe Tyr Pro Lys 
            260                 265                 270         


Ala Arg Gly Pro Val Phe Phe Ile Asn Thr Glu Lys Phe Gln Thr Met 
        275                 280                 285             


Glu Ser Val Asn Leu Met Lys Lys Ile Cys Ala Gln His Glu Gln Ser 
    290                 295                 300                 


Arg Ile Ile Thr Val Leu Gly Ser Val His Arg Ser Gln Thr Asp Phe 
305                 310                 315                 320 


Ala Phe Val Thr Gly Asn Leu Ile Gly Lys Phe Phe Ser Thr Glu Thr 
                325                 330                 335     


Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Val Met Val Arg Ala 
            340                 345                 350         


Met Leu Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asn 
        355                 360                 365             


Gln Trp Asn Asn Leu Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly 
    370                 375                 380                 


Ala Pro His His Leu Ser Ser Leu 
385                 390         


<210>  5608
<211>  2503
<212>  DNA
<213>  Homosapiens

<400>  5608
gcaacaggaa gccgagagga aaccagcaag cggctgctgt tctgtgttcc cccatccagc     60

cagcaagttc agctccggca agtcatttga ttcacccggt gatgaaatgg gggtcaacca    120

gtctgtgggc tttccacctg tcacaggacc ccacctcgta ggctgtgggg atgtgatgga    180

gggtcagaat ctccagggga gcttctttcg actcttctac ccctgccaaa aggcagagga    240

gaccatggag cagcccctgt ggattccccg ctatgagtac tgcactggcc tggccgagta    300

cctgcagttt aataagcgct gcgggggctt gctgttcaac ctggcggtgg gatcttgtcg    360

cctgcctgtt agctggaatg gcccctttaa gacaaaggac tctggatacc ccttgatcat    420

cttctcccat ggcctaggag ccttcaggac tttgtattca gccttctgca tggagctggc    480

ctcacgtggc tttgtggttg ctgtgccaga gcacagggac cggtcagcgg caaccaccta    540

tttctgcaag caggccccag aagagaacca gcccaccaat gaatcgctgc aggaggaatg    600

gatccctttc cgtcgagttg aggaagggga gaaggaattt catgttcgga atccccaggt    660

gcatcagcgg gtaagcgagt gtttacgggt gttgaagatc ctgcaagagg tcactgctgg    720

gcagactgtc ttcaacatct tgcctggtgg cttggatctg atgactttga agggcaacat    780

tgacatgagc cgtgtggctg tgatgggaca ttcatttgga ggggccacag ctattctggc    840

tttggccaag gagacccaat ttcggtgtgc ggtggctctg gatgcttgga tgtttcctct    900

ggaacgtgac ttttacccca aggcccgagg acctgtgttc tttatcaata ctgagaaatt    960

ccagacaatg gagagtgtca atttgatgaa gaagatatgt gcccagcatg aacagtctag   1020

gatcataacc gttcttggtt ctgttcatcg gagtcaaact gactttgctt ttgtgactgg   1080

caacttgatt ggtaaattct tctccactga aacccgtggg agcctggacc cctatgaagg   1140

gcaggaggtt atggtacggg ccatgttggc cttcctgcag aagcacctcg acctgaaaga   1200

agactataat caatggaaca accttattga aggcattgga ccgtcgctca ccccaggggc   1260

cccccaccat ctgtccagcc tgtaggcaca actggccatt tgtaaagtca cttcagccaa   1320

gttttcattt gggagctacc caagggcacc catgagctcc tatcaagaag tgatcaacgt   1380

gacccctttt cacagattga aaggtgtaat cacactgctg cttggataac tgggtacttt   1440

gatcttagat ttgatcttaa aatcactttg ggactgggat cccttgctga ttgacaaaca   1500

gactttctgg gaccttgatg gagtggggaa caagcagtag agtgggactg ggggagaccc   1560

aggccccggg ctgagcactg tgaggcctgg atgtgaagac tcagcccagc gaagctcatt   1620

cccttacccc cggccagtgc tgctgcttca gtggaagaga tgaagccaaa ggacagaatg   1680

aaaatcccta ccttcagaga ctctagccca gcccaacacc atctcttcct acctctcagc   1740

cttctccctc cccagggcca cttgttgaag tctgagcact ttatgtaaat ttctaggtgt   1800

gagccgtgat cacattttct atttatttcc aagtcttctc attgtatgga acatagtact   1860

acttatactt acagtagtaa gttatacttg tgagcccaca gagtggcaga cagcatggct   1920

ctcacagcac agggagaaaa actgaggtac acagaggtac ctcagaagct ctggatgtct   1980

ttgggggttt tgctaagtgt atcttgatag gaaacaacaa aagcaggttg agatggggaa   2040

gatgacagaa caacagtgtt aaatggccat ttgcacaggc ctttgccaca acagagaagt   2100

agtttggtca gctaaaactc agctgcagcc tggacagtag agcgagaccc catcttaaaa   2160

ataaagaagg ctgggcgtgg tggctcatgc ctgtaatccc aacactttgg gaggccaagg   2220

caggcagatc acttaaggcc aggagttcaa gaccacctgg ccaacatggt gaaaccccgt   2280

ctctactaaa aatacaaaaa attagcctgg cgtaatggca ggcgcctata atcccagcta   2340

ctcaggaggc tgaagcagaa gaatcacttg aacctaggag gcggaggttg cagtgagtca   2400

agatcgcgcc actgcactcc agcctgggtg acagagcaag actctgtctt aaaaaaaaaa   2460

aaaagaaaaa gaaaaattta aaataaataa aatttaaaaa cgc                     2503


<210>  5609
<211>  392
<212>  PRT
<213>  Homosapiens

<400>  5609

Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His 
1               5                   10                  15      


Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser 
            20                  25                  30          


Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu 
        35                  40                  45              


Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu 
    50                  55                  60                  


Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala 
65                  70                  75                  80  


Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr 
                85                  90                  95      


Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala 
            100                 105                 110         


Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly 
        115                 120                 125             


Phe Val Val Ala Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr 
    130                 135                 140                 


Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro Thr Asn Glu Ser 
145                 150                 155                 160 


Leu Gln Glu Glu Trp Ile Pro Phe Arg Arg Val Glu Glu Gly Glu Lys 
                165                 170                 175     


Glu Phe His Val Arg Asn Pro Gln Val His Gln Arg Val Ser Glu Cys 
            180                 185                 190         


Leu Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala Gly Gln Thr Val 
        195                 200                 205             


Phe Asn Ile Leu Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Asn 
    210                 215                 220                 


Ile Asp Met Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala 
225                 230                 235                 240 


Thr Ala Ile Leu Ala Leu Ala Lys Glu Thr Gln Phe Arg Cys Ala Val 
                245                 250                 255     


Ala Leu Asp Ala Trp Met Phe Pro Leu Glu Arg Asp Phe Tyr Pro Lys 
            260                 265                 270         


Ala Arg Gly Pro Val Phe Phe Ile Asn Thr Glu Lys Phe Gln Thr Met 
        275                 280                 285             


Glu Ser Val Asn Leu Met Lys Lys Ile Cys Ala Gln His Glu Gln Ser 
    290                 295                 300                 


Arg Ile Ile Thr Val Leu Gly Ser Val His Arg Ser Gln Thr Asp Phe 
305                 310                 315                 320 


Ala Phe Val Thr Gly Asn Leu Ile Gly Lys Phe Phe Ser Thr Glu Thr 
                325                 330                 335     


Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Val Met Val Arg Ala 
            340                 345                 350         


Met Leu Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asn 
        355                 360                 365             


Gln Trp Asn Asn Leu Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly 
    370                 375                 380                 


Ala Pro His His Leu Ser Ser Leu 
385                 390         


<210>  5610
<211>  354
<212>  DNA
<213>  Homosapiens

<400>  5610
atcttctggg ctcaagagat cttcctacct cagtgtcctg agtagctggg actacaggca     60

cacaccacca cacaattttg tttttttagt agagacgggg tcttgctatg ttgcccaggc    120

tggtctcaaa ctcctgaact caagcgatcc tcccactgtg gccttccaaa gtgctggaga    180

tataggtgtg agccacggca cccagtcaga accacagctc ttgacagctc tgaccttgtg    240

tgtgttcagc cttgtcacct atgagaatag gactgtgttt gagttgctcc ctcagtccct    300

taccctggtg ccaaactgca gtttgaaaaa tcctggagag ggattccagg cctg          354


<210>  5611
<211>  116
<212>  PRT
<213>  Homosapiens

<400>  5611

Ser Ser Gly Leu Lys Arg Ser Ser Tyr Leu Ser Val Leu Ser Ser Trp 
1               5                   10                  15      


Asp Tyr Arg His Thr Pro Pro His Asn Phe Val Phe Leu Val Glu Thr 
            20                  25                  30          


Gly Ser Cys Tyr Val Ala Gln Ala Gly Leu Lys Leu Leu Asn Ser Ser 
        35                  40                  45              


Asp Pro Pro Thr Val Ala Phe Gln Ser Ala Gly Asp Ile Gly Val Ser 
    50                  55                  60                  


His Gly Thr Gln Ser Glu Pro Gln Leu Leu Thr Ala Leu Thr Leu Cys 
65                  70                  75                  80  


Val Phe Ser Leu Val Thr Tyr Glu Asn Arg Thr Val Phe Glu Leu Leu 
                85                  90                  95      


Pro Gln Ser Leu Thr Leu Val Pro Asn Cys Ser Leu Lys Asn Pro Gly 
            100                 105                 110         


Glu Gly Phe Gln 
        115     


<210>  5612
<211>  4017
<212>  DNA
<213>  Homosapiens

<400>  5612
agttgccgac tggagaggga tgggaggaga taccataggg tttggggggc ttggcacagc     60

ggccctggcc tctgcactgt gatagctcca agccagatgg tgcaaggcag ctgctgggct    120

gcggggaaga ggggctgcac ttcctgagct ggtgcagcgg cagagtggat aaggatcagg    180

accccgagcc ctcctggccc tccaaggcag ggggacaccg gctgcaccca ggctgtgacc    240

tcagctgacg ccgatgatcc acatgggatg cagggtctaa ttttagctcc agccacaggg    300

gccacagccc agaagcgtct gccagcgggc acaggggcag ccagggctgc tcaggcaagg    360

ggaggagtgg gaagaccagc ccagctccct ccagcctgtc cctggccaag ccgcctcctg    420

tgggagctct gactggtccc catggcctgg cagacagccc tcctctcagt tgagggcaag    480

gtcaaggggt gcagccagga gggcaggggg acacggccct gcattctgga caggggttgc    540

gtcagccaga gcagtgccca ggggcagggg tccctgctgg gagggaaaag gctggcttgg    600

ttgtccaaag gccgagaagg cagagtcctg agagcagggg ggccaggcca gcaagctggg    660

tcccacctgg cctcctcctg cctggctggt gactcactat ctgaccttag acaggcggcc    720

tggtctcgat gggcctcagt cttcccatct gtacaatgac agcacaggac tagcaggtcg    780

gtcccagctc tggtctcccg ccccaggccc tgctcttcct gcttgctggc agaggcctcc    840

cagcttccct agccctgact gtgggtggcc acatgcagtc gtggaggaga agaaagtccc    900

tgtggctggc actgtcagcc tcctggctcc tgcttgtcct gctgggaggc ttctcccttc    960

tccgcctggc attgcctccc agacctcggc ccggggcttc ccaaggctgg ccccgctggc   1020

tggatgcaga gctcctgcag agcttctccc agcctggaga gctcccagaa gatgccgttt   1080

cacctcctca agcccctcat ggtggcagct gcaactggga atcttgcttt gatacctcaa   1140

agtgcagggg cgatggcctt aaggtattcg tgtacccagc ggttggaacc atctctgaga   1200

ctcatcgcag gatcctggct tccattgagg gctctcgctt ctacacattc agccctgctg   1260

gggcctgcct cctcctcctc ctcagcctgg acgcccagac tggagagtgc agctcaatgc   1320

ctctgcaatg gaacaggggc aggaaccatc tggtcctccg tctccacccg gctccctgcc   1380

ccaggacctt ccagctggga caggctatgg tggctgaggc cagccccacg gtggactcct   1440

tccggcccgg ctttgatgtg gccctccctt ttctccctga agcccacccg ttgcgaggtg   1500

gggctcctgg ccagctgcgg caacacagcc cccagcccgg ggtagccctg ctagccctgg   1560

aagaggagag gggtgggtgg cgcacagcag acactggctc ctctgcctgc ccctgggatg   1620

ggcgctgtga gcaagaccct ggacctgggc agacccagcg ccaggagacg ctgcccaatg   1680

ccaccttctg cctcatctct ggccaccgtc ccgaggctgc ctcgcgcttc ctccaagccc   1740

tgcaggccgg ctgcatccca gtgcttctca gcccccgctg ggagctgccc ttctccgagg   1800

tcatcgactg gaccaaggca gccatcgtag ctgatgagag gctcccactt caggtcctgg   1860

ctgccctcca ggagatgtcc cctgcacggg tcctcgccct gcgtcagcag acccagtttc   1920

tatgggatgc ctacttctcc tcagtggaga aggtcatcca taccactctg gaggttattc   1980

aggaccggat ttttggaaca tcagctcacc cctcactgct gtggaacagc cccccagggg   2040

cactcctggc cctgtctact ttttccacaa gcccccagga cttccccttc tactacctgc   2100

aacagggctc ccgccctgag ggcagattca gcgccctgat ctgggtgggg cccccaggcc   2160

agccccctct gaagctcatc caggcggtgg caggctccca gcactgtgcc cagatcttgg   2220

ttctctggag caatgagagg ccactcccat ccaggtggcc ggagacagct gtgcccttga   2280

cagtcattga tgggcacagg aaggttagtg atcgcttcta cccatatagc accatcagaa   2340

cagatgccat cctcagcctc gatgcccgca gcagtctttc cacaagtgag gtggactttg   2400

cctttctggt gtggcagagc ttcccagagc ggatggtggg cttcctgacg tcgagccatt   2460

tctgggacga ggcccatggt ggctggggct acactgctga gaggaccaac gaattctcca   2520

tggttctcac cacagccgcc ttctaccata ggtattacca cactctcttc acccactccc   2580

tgcccaaggc tctgaggacc ctggcagatg aggcacccac ctgtgtggac gtcctgatga   2640

atttcatagt agcagcagtc accaagctgc cccctatcaa ggtgccctat ggcaagcagc   2700

gccaggaggc tgctccactg gcgcctgggg gcccggggcc caggccaaag ccgcctgccc   2760

cagcccccga ctgcatcaac cagatagcgg cagcgttcgg ccacatgccc ttgctgtcct   2820

ctcgtctgcg tctggacccg gtgctgttta aggacccggt gtccgtgcag cgcaagaagt   2880

accgcagcct ggagaagccc taggggggcg acccgcggag accccagcag aggtcgcagc   2940

ccagctccca gggggcccgg cgcctgccgg cgggctccgc tcttgggaca ccggagaacc   3000

tatcatgtca gccagcgggc ccacacgtcg gaccccggtt ggccaatcac aacagggggg   3060

cgtggcctta ccttctcctg ctcgccctca gccgcggagc ctctgcggag gctgagcccc   3120

gcgaccggag cgccgctctc cgcttctcca cccagctaac ttctgctcgt ctttcagagc   3180

attgtctcct ccagggactt gcctggccct cctccccctc cgcccccaat gggttcggtc   3240

tcctttgcgc tttcgcagtc cagtgtttgc cgcggttccc gcacggtcag gccccaggac   3300

tggcttgcga gccccggggg gcgggtcgtg tcgtgtcctt ttctctctgg ctaggcaggt   3360

gtgccgcaaa tatttgacga atagatggat ggcagacatt aactgcgtgc ctggccctat   3420

gagggcggcg gcgggacagg gtgagcggag agacagaact gtccccgccc caccccgcca   3480

cccattccta gggttcctag tcccgggaag gcaactaccc aaagacgcct gggttgtcag   3540

gctcaatcct tgagcctcaa ccaaggagca gaggggtgcg ggtaaacgag gagtggggcg   3600

aggaaagcgg gatgggaaca agtggcctgt ccccgcacgg cccgcggctc agcctcggcc   3660

gtctgccctg cactaccaag gccgaccact agaggtcagc gtcgcgccgc actcttcacc   3720

cgcatgtcca gagggcggcc gggatgtgga gggtgagcgc tgtgggcagc tcgggggctg   3780

aaagctggga agagaaatct gaagaacagc cccatctctt tcgcctgcac acttggaact   3840

cagcaagaag ggactgtttc taggtgggct gggcgcgagc agggactgtc ccgagcggta   3900

taggtgagaa tggagttggg gggggacact aggtcctccg gggttcaccc acctggagct   3960

ggaattatca cttccgaaat aaagcgcgtg tccttgcccc ctcacgctcc aggctat      4017


<210>  5613
<211>  676
<212>  PRT
<213>  Homosapiens

<400>  5613

Met Gln Ser Trp Arg Arg Arg Lys Ser Leu Trp Leu Ala Leu Ser Ala 
1               5                   10                  15      


Ser Trp Leu Leu Leu Val Leu Leu Gly Gly Phe Ser Leu Leu Arg Leu 
            20                  25                  30          


Ala Leu Pro Pro Arg Pro Arg Pro Gly Ala Ser Gln Gly Trp Pro Arg 
        35                  40                  45              


Trp Leu Asp Ala Glu Leu Leu Gln Ser Phe Ser Gln Pro Gly Glu Leu 
    50                  55                  60                  


Pro Glu Asp Ala Val Ser Pro Pro Gln Ala Pro His Gly Gly Ser Cys 
65                  70                  75                  80  


Asn Trp Glu Ser Cys Phe Asp Thr Ser Lys Cys Arg Gly Asp Gly Leu 
                85                  90                  95      


Lys Val Phe Val Tyr Pro Ala Val Gly Thr Ile Ser Glu Thr His Arg 
            100                 105                 110         


Arg Ile Leu Ala Ser Ile Glu Gly Ser Arg Phe Tyr Thr Phe Ser Pro 
        115                 120                 125             


Ala Gly Ala Cys Leu Leu Leu Leu Leu Ser Leu Asp Ala Gln Thr Gly 
    130                 135                 140                 


Glu Cys Ser Ser Met Pro Leu Gln Trp Asn Arg Gly Arg Asn His Leu 
145                 150                 155                 160 


Val Leu Arg Leu His Pro Ala Pro Cys Pro Arg Thr Phe Gln Leu Gly 
                165                 170                 175     


Gln Ala Met Val Ala Glu Ala Ser Pro Thr Val Asp Ser Phe Arg Pro 
            180                 185                 190         


Gly Phe Asp Val Ala Leu Pro Phe Leu Pro Glu Ala His Pro Leu Arg 
        195                 200                 205             


Gly Gly Ala Pro Gly Gln Leu Arg Gln His Ser Pro Gln Pro Gly Val 
    210                 215                 220                 


Ala Leu Leu Ala Leu Glu Glu Glu Arg Gly Gly Trp Arg Thr Ala Asp 
225                 230                 235                 240 


Thr Gly Ser Ser Ala Cys Pro Trp Asp Gly Arg Cys Glu Gln Asp Pro 
                245                 250                 255     


Gly Pro Gly Gln Thr Gln Arg Gln Glu Thr Leu Pro Asn Ala Thr Phe 
            260                 265                 270         


Cys Leu Ile Ser Gly His Arg Pro Glu Ala Ala Ser Arg Phe Leu Gln 
        275                 280                 285             


Ala Leu Gln Ala Gly Cys Ile Pro Val Leu Leu Ser Pro Arg Trp Glu 
    290                 295                 300                 


Leu Pro Phe Ser Glu Val Ile Asp Trp Thr Lys Ala Ala Ile Val Ala 
305                 310                 315                 320 


Asp Glu Arg Leu Pro Leu Gln Val Leu Ala Ala Leu Gln Glu Met Ser 
                325                 330                 335     


Pro Ala Arg Val Leu Ala Leu Arg Gln Gln Thr Gln Phe Leu Trp Asp 
            340                 345                 350         


Ala Tyr Phe Ser Ser Val Glu Lys Val Ile His Thr Thr Leu Glu Val 
        355                 360                 365             


Ile Gln Asp Arg Ile Phe Gly Thr Ser Ala His Pro Ser Leu Leu Trp 
    370                 375                 380                 


Asn Ser Pro Pro Gly Ala Leu Leu Ala Leu Ser Thr Phe Ser Thr Ser 
385                 390                 395                 400 


Pro Gln Asp Phe Pro Phe Tyr Tyr Leu Gln Gln Gly Ser Arg Pro Glu 
                405                 410                 415     


Gly Arg Phe Ser Ala Leu Ile Trp Val Gly Pro Pro Gly Gln Pro Pro 
            420                 425                 430         


Leu Lys Leu Ile Gln Ala Val Ala Gly Ser Gln His Cys Ala Gln Ile 
        435                 440                 445             


Leu Val Leu Trp Ser Asn Glu Arg Pro Leu Pro Ser Arg Trp Pro Glu 
    450                 455                 460                 


Thr Ala Val Pro Leu Thr Val Ile Asp Gly His Arg Lys Val Ser Asp 
465                 470                 475                 480 


Arg Phe Tyr Pro Tyr Ser Thr Ile Arg Thr Asp Ala Ile Leu Ser Leu 
                485                 490                 495     


Asp Ala Arg Ser Ser Leu Ser Thr Ser Glu Val Asp Phe Ala Phe Leu 
            500                 505                 510         


Val Trp Gln Ser Phe Pro Glu Arg Met Val Gly Phe Leu Thr Ser Ser 
        515                 520                 525             


His Phe Trp Asp Glu Ala His Gly Gly Trp Gly Tyr Thr Ala Glu Arg 
    530                 535                 540                 


Thr Asn Glu Phe Ser Met Val Leu Thr Thr Ala Ala Phe Tyr His Arg 
545                 550                 555                 560 


Tyr Tyr His Thr Leu Phe Thr His Ser Leu Pro Lys Ala Leu Arg Thr 
                565                 570                 575     


Leu Ala Asp Glu Ala Pro Thr Cys Val Asp Val Leu Met Asn Phe Ile 
            580                 585                 590         


Val Ala Ala Val Thr Lys Leu Pro Pro Ile Lys Val Pro Tyr Gly Lys 
        595                 600                 605             


Gln Arg Gln Glu Ala Ala Pro Leu Ala Pro Gly Gly Pro Gly Pro Arg 
    610                 615                 620                 


Pro Lys Pro Pro Ala Pro Ala Pro Asp Cys Ile Asn Gln Ile Ala Ala 
625                 630                 635                 640 


Ala Phe Gly His Met Pro Leu Leu Ser Ser Arg Leu Arg Leu Asp Pro 
                645                 650                 655     


Val Leu Phe Lys Asp Pro Val Ser Val Gln Arg Lys Lys Tyr Arg Ser 
            660                 665                 670         


Leu Glu Lys Pro 
        675     


<210>  5614
<211>  1401
<212>  DNA
<213>  Homosapiens

<400>  5614
ggagaagaaa gtccctgtgg ctggcactgt cagcctcctg gctcctgctt gtcctgctgg     60

gaggcttctc ccttctccgc ctggcattgc ctcccagacc tcggcccggg gcttcccaag    120

gctggccccg ctggctggat gcagagctcc tgcagagctt ctcccagcct ggagagctcc    180

cagaagatgc cgtttcacct cctcaagccc ctcatggtgg cagctgcaac tgggaatctt    240

gctttgatac ctcaaagtgc aggggcgatg gccttaaggt attcgtgtac ccagcggttg    300

gaaccatctc tgagactcat cgcaggatcc tggcttccat tgagggctct cgcttctaca    360

cattcagccc tgctggggcc tgcctcctcc tcctcctcag cctggacgcc cagactggag    420

agtgcagctc aatgcctctg caatggaaca ggggcaggaa ccatctggtc ctccgtctcc    480

acccggctcc ctgccccagg accttccagc tgggacaggc tatggtggct gaggccagcc    540

ccacggtgga ctccttccgg cccggctttg atgtggccct cccttttctc cctgaagccc    600

acccgttgcg aggtggggct cctggccagc tgcggcaaca cagcccccag cccggggtag    660

ccctgctagc cctggaagag gagaggggtg ggtggcgcac agcagacact ggctcctctg    720

cctgcccctg ggatgggcgc tgtgagcaag accctggacc tgggcagacc cagcgccagg    780

agacgctgcc caatgccacc ttctgcctca tctctggcca ccgtcccgag gctgcctcgc    840

gcttcctcca agccctgcag gtcctggctg ccctccagga gatgtcccct gcacgggtcc    900

tcgccctgcg tcagcagacc cagtttctat gggatgccta cttctcctca gtggagaagg    960

tcatccatac cactctggag gttattcagg accggatttt tggaacatca gctcacccct   1020

cactgctgtg gaacagcccc ccaggggcac tcctggccct gtctactttt tccacaagcc   1080

cccaggactt ccccttctac tacctgcaac agggtatgcc ctggggatgg gacaacctga   1140

agtcccctca gctctaccca gggctgcccc agcctcatct ggagagcccc accaagaccc   1200

tttccaagcc ctaacatttt tcctggcccc cggggattcc ctactcaggt cattcttcat   1260

ggggttctgt tccctcccac tctaatagcc tgtgtctcat tcccccaggc tcccgccctg   1320

agggcagatt cagcgccctg atctgggtgg ggcccccagg ccagccccct ctgaagctca   1380

tccaggcggt ggcaggctcc c                                             1401


<210>  5615
<211>  260
<212>  PRT
<213>  Homosapiens

<400>  5615

Met Pro Leu Gln Trp Asn Arg Gly Arg Asn His Leu Val Leu Arg Leu 
1               5                   10                  15      


His Pro Ala Pro Cys Pro Arg Thr Phe Gln Leu Gly Gln Ala Met Val 
            20                  25                  30          


Ala Glu Ala Ser Pro Thr Val Asp Ser Phe Arg Pro Gly Phe Asp Val 
        35                  40                  45              


Ala Leu Pro Phe Leu Pro Glu Ala His Pro Leu Arg Gly Gly Ala Pro 
    50                  55                  60                  


Gly Gln Leu Arg Gln His Ser Pro Gln Pro Gly Val Ala Leu Leu Ala 
65                  70                  75                  80  


Leu Glu Glu Glu Arg Gly Gly Trp Arg Thr Ala Asp Thr Gly Ser Ser 
                85                  90                  95      


Ala Cys Pro Trp Asp Gly Arg Cys Glu Gln Asp Pro Gly Pro Gly Gln 
            100                 105                 110         


Thr Gln Arg Gln Glu Thr Leu Pro Asn Ala Thr Phe Cys Leu Ile Ser 
        115                 120                 125             


Gly His Arg Pro Glu Ala Ala Ser Arg Phe Leu Gln Ala Leu Gln Val 
    130                 135                 140                 


Leu Ala Ala Leu Gln Glu Met Ser Pro Ala Arg Val Leu Ala Leu Arg 
145                 150                 155                 160 


Gln Gln Thr Gln Phe Leu Trp Asp Ala Tyr Phe Ser Ser Val Glu Lys 
                165                 170                 175     


Val Ile His Thr Thr Leu Glu Val Ile Gln Asp Arg Ile Phe Gly Thr 
            180                 185                 190         


Ser Ala His Pro Ser Leu Leu Trp Asn Ser Pro Pro Gly Ala Leu Leu 
        195                 200                 205             


Ala Leu Ser Thr Phe Ser Thr Ser Pro Gln Asp Phe Pro Phe Tyr Tyr 
    210                 215                 220                 


Leu Gln Gln Gly Met Pro Trp Gly Trp Asp Asn Leu Lys Ser Pro Gln 
225                 230                 235                 240 


Leu Tyr Pro Gly Leu Pro Gln Pro His Leu Glu Ser Pro Thr Lys Thr 
                245                 250                 255     


Leu Ser Lys Pro 
            260 


<210>  5616
<211>  2361
<212>  DNA
<213>  Homosapiens

<400>  5616
cggggcgcag cggctgaccc gagacacggg agcgcttggc acgcggagcc agagccggag     60

ctgcagccgc agcgggagcc gggggagctc aggggccgca ggagccgggc cggagtgagc    120

gcacctcgcg gggccctcgg ggcaggtggg tgagcgccac ccggagtccc gcgcgcaact    180

ttcagggcgc actcggcggg gcggctgcgc ggctgccggg actcggcgcg ggactgcatg    240

gaggccaagg agaagcagca tctgttggac gccaggccgg caatccggtc atacacggga    300

tctctgtggc aggaaggggc tggctggatt cctctgcccc gacctggcct ggacttgcag    360

gccattgagc tggctgccca gagcaaccat cactgccatg ctcagaaggg tcctgacagt    420

cactgtgacc ccaagaaggg gaaggcccag cgccagctgt atgtagcctc tgccatctgc    480

ctgttgttca tgatcggaga agtcgttggt gggtacctgg cacacagctt ggctgtcatg    540

actgacgcag cacacctgct cactgacttt gccagcatgc tcatcagcct cttctccctc    600

tggatgtcct cccggccagc caccaagacc atgaactttg gctggcagag agctgagatc    660

ttgggagccc tggtctctgt actgtccatc tgggtcgtga cgggggtact ggtgtacctg    720

gctgtggagc ggctgatctc tggggactat gaaattgacg gggggaccat gctgatcacg    780

tcgggctgcg ctgtggctgt gaacatcata atggggttga cccttcacca gtctggccat    840

gggcacagcc acggcaccac caaccagcag gaggagaacc ccagcgtccg agctgccttc    900

atccatgtga tcggcgactt tatgcagagc atgggtgtcc tagtggcagc ctatatttta    960

tacttcaagc cagaatacaa gtatgtagac cccatcttcc aggaatggag ctcttcccag   1020

cctcccatct gactacagcc agggtgggga ctcagcgggt ataaagctag tgtgaccctg   1080

ctcttccagc tcctgggcca gctctggaag ggctgtattt gggcctaatc ctcagcaaat   1140

gttctaccac tcgcaggggc aaaggtggtg agccacggga cgtccaaggg gaggctggcc   1200

ccagcgcgcc catactgcct gcctcatgcc ccattctcag cctggctggc ctttgccttt   1260

atgaatctga gcccctccat ctgcctatag caataggcac gggggtgagg accctcacac   1320

tctcatttga gcctccctga ggcagggagc caggaggcac ctgaggccta tctgtgcctt   1380

agtcacttca gctatgagcc aaatgttccc tttcctggag gggagaggct tcttactagg   1440

taagagacag gtttcctctt tccttatttc ctcagctgtg ccaacacaaa aaacaacttt   1500

ggcacaggtg gtgggcaggg ggtagagaga tttcagcttg ggttctgcac taacagcctc   1560

caagccccct ggcacttctg ttgccctgag agtgtcccag gggattcaga gtctccagaa   1620

agatatggct gggccaactc tgttgcctac ctggcctgac ccagtcggag cctgacatgg   1680

tggagggaaa gggagacaag tggggctgca ctcggtccag aggccagcta ggagggaaac   1740

cgcagcttcc tggggcttgt gtgtgaagat tcctgactta ggggtggctt ttgtttacaa   1800

gatgcaagag gggaaacctg tccccgactc atcgagacaa catgcccagt tatcagggag   1860

tcctgtgtca caaggtctgt ctctgccatt gtaagcaagt gccttgggcg agctggcctc   1920

tgccccacag tctcatctgt acaccgacag ggttgatgcc tccctcacag ggttgagaac   1980

aagagccagt tggccaagta cctgtggttg ttgaagattg gttactttta ccatcctggg   2040

gacagggaac tctgtggccc gaggctgcct cactgaggag tcaggtgggc ttcccagcct   2100

ccccaggggc agtgctgagt ttgtcttgac tgttctggcc caaggtggga ggaggtgggt   2160

ttggtcactt gcctcccact ttaaatctct gtctttccat ctgtgaaatg acctctttgt   2220

gccttcccag cactgtcatc ctgatcgcct gtgttctagg taggtgggtc cttcagcccc   2280

tccaggtctg tgaaaagtct gtggaaagca ctggcctgga gaggggtggg gggttgctgg   2340

tgggtgctcc attccaccac a                                             2361


<210>  5617
<211>  264
<212>  PRT
<213>  Homosapiens

<400>  5617

Met Glu Ala Lys Glu Lys Gln His Leu Leu Asp Ala Arg Pro Ala Ile 
1               5                   10                  15      


Arg Ser Tyr Thr Gly Ser Leu Trp Gln Glu Gly Ala Gly Trp Ile Pro 
            20                  25                  30          


Leu Pro Arg Pro Gly Leu Asp Leu Gln Ala Ile Glu Leu Ala Ala Gln 
        35                  40                  45              


Ser Asn His His Cys His Ala Gln Lys Gly Pro Asp Ser His Cys Asp 
    50                  55                  60                  


Pro Lys Lys Gly Lys Ala Gln Arg Gln Leu Tyr Val Ala Ser Ala Ile 
65                  70                  75                  80  


Cys Leu Leu Phe Met Ile Gly Glu Val Val Gly Gly Tyr Leu Ala His 
                85                  90                  95      


Ser Leu Ala Val Met Thr Asp Ala Ala His Leu Leu Thr Asp Phe Ala 
            100                 105                 110         


Ser Met Leu Ile Ser Leu Phe Ser Leu Trp Met Ser Ser Arg Pro Ala 
        115                 120                 125             


Thr Lys Thr Met Asn Phe Gly Trp Gln Arg Ala Glu Ile Leu Gly Ala 
    130                 135                 140                 


Leu Val Ser Val Leu Ser Ile Trp Val Val Thr Gly Val Leu Val Tyr 
145                 150                 155                 160 


Leu Ala Val Glu Arg Leu Ile Ser Gly Asp Tyr Glu Ile Asp Gly Gly 
                165                 170                 175     


Thr Met Leu Ile Thr Ser Gly Cys Ala Val Ala Val Asn Ile Ile Met 
            180                 185                 190         


Gly Leu Thr Leu His Gln Ser Gly His Gly His Ser His Gly Thr Thr 
        195                 200                 205             


Asn Gln Gln Glu Glu Asn Pro Ser Val Arg Ala Ala Phe Ile His Val 
    210                 215                 220                 


Ile Gly Asp Phe Met Gln Ser Met Gly Val Leu Val Ala Ala Tyr Ile 
225                 230                 235                 240 


Leu Tyr Phe Lys Pro Glu Tyr Lys Tyr Val Asp Pro Ile Phe Gln Glu 
                245                 250                 255     


Trp Ser Ser Ser Gln Pro Pro Ile 
            260                 


<210>  5618
<211>  1999
<212>  DNA
<213>  Homosapiens

<400>  5618
cggggcgcag cggctgaccc gagacacggg agcgcttggc acgcggagcc agagccggag     60

ctgcagccgc agcgggagcc gggggagctc aggggccgca ggagccgggc cggagtgagc    120

gcacctcgcg gggccctcgg ggcaggtggg tgagcgccac ccggagtccc gcgcgcaact    180

ttcagggcgc actcggcggg gcggctgcgc ggctgccggg actcggcgcg ggactgcatg    240

gaggccaagg agaagcagca tctgttggac gccaggccgg caatccggtc atacacggga    300

tctctgtggc aggaaggggc tggctggatt cctctgcccc gacctggcct ggacttgcag    360

gccattgagc tggctgccca gagcaaccat cactgccatg ctcagaaggg tcctgacagt    420

cactgtgacc ccaagaaggg gaaggcccag cgccagctgt atgtagcctc tgccatctgc    480

ctgttgttca tgatcggaga agtcgttggt gggtacctgg cacacagctt ggctgtcatg    540

actgacgcag cacacctgct cactgacttt gccagcatgc tcatcagcct cttctccctc    600

tggatgtcct cccggccagc caccaagacc atgaactttg gctggcagag agctgagatc    660

ttgggagccc tggtctctgt actgtccatc tgggtcgtga cgggggtact ggtgtacctg    720

gctgtggagc ggctgatctc tggggactat gaaattgacg gggggaccat gctgatcacg    780

tcgggctgcg ctgtggctgt gaacatcata atggggttga cccttcacca gtctggccat    840

gggcacagcc acggcaccac caaccagcag gaggagaacc ccagcgtccg agctgccttc    900

atccatgtga tcggcgactt tatgcagagc atgggtgtcc tagtggcagc ctatatttta    960

tacttcaagc cagaatacaa gtatgtagac cccatcttcc aggaatggag ctcttcccag   1020

cctcccatct gactacagcc agggtgggga ctcagcgggt ataaagctag tgtgaccctg   1080

ctcttccagc tcctgggcca gctctggaag ggctgtattt gggcctaatc ctcagcaaat   1140

gttctaccac tcgcaggggc aaaggtggtg agccacggga cgtccaaggg gaggctggcc   1200

ccagcgcgcc catactgcct gcctcatgcc ccattctcag cctggctggc ctttgccttt   1260

atgaatctga gcccctccat ctgcctatag caataggcac gggggtgagg accctcacac   1320

tctcatttga gcctccctga ggcagggagc caggaggcac ctgaggccta tctgtgcctt   1380

agtcacttca gctatgagcc aaatgttccc tttcctggag gggagaggct tcttactagg   1440

taagagacag gtttcctctt tccttatttc ctcagctgtg ccaacacaaa aaacaacttt   1500

ggcacaggtg gtgggcaggg ggtagagaga tttcagcttg ggttctgcac taacagcctc   1560

caagccccct ggcacttctg ttgccctgag agtgtcccag gggattcaga gtctccagaa   1620

agatatggct gggccaactc tgttgcctac ctggcctgac ccagtcggag cctgacatgg   1680

tggagggaaa gggagacaag tggggctgca ctcggtccag aggccagcta ggagggaaac   1740

cgcagcttcc tggggcttgt gtgtgaagat tcctgactta ggggtggctt ttgtttacaa   1800

gatgcaagag gggaaacctg tccccgactc atcgagacaa catgcccagt tatcagggag   1860

tcctgtgtca caaggtctgt ctctgccatt gtaagcaagt gccttgggcg agctggcctc   1920

tgccccacag tctcatctgt acaccgacag ggttgatgcc tccctcacag ggttgagaac   1980

aagagccagt tggccaagt                                                1999


<210>  5619
<211>  264
<212>  PRT
<213>  Homosapiens

<400>  5619

Met Glu Ala Lys Glu Lys Gln His Leu Leu Asp Ala Arg Pro Ala Ile 
1               5                   10                  15      


Arg Ser Tyr Thr Gly Ser Leu Trp Gln Glu Gly Ala Gly Trp Ile Pro 
            20                  25                  30          


Leu Pro Arg Pro Gly Leu Asp Leu Gln Ala Ile Glu Leu Ala Ala Gln 
        35                  40                  45              


Ser Asn His His Cys His Ala Gln Lys Gly Pro Asp Ser His Cys Asp 
    50                  55                  60                  


Pro Lys Lys Gly Lys Ala Gln Arg Gln Leu Tyr Val Ala Ser Ala Ile 
65                  70                  75                  80  


Cys Leu Leu Phe Met Ile Gly Glu Val Val Gly Gly Tyr Leu Ala His 
                85                  90                  95      


Ser Leu Ala Val Met Thr Asp Ala Ala His Leu Leu Thr Asp Phe Ala 
            100                 105                 110         


Ser Met Leu Ile Ser Leu Phe Ser Leu Trp Met Ser Ser Arg Pro Ala 
        115                 120                 125             


Thr Lys Thr Met Asn Phe Gly Trp Gln Arg Ala Glu Ile Leu Gly Ala 
    130                 135                 140                 


Leu Val Ser Val Leu Ser Ile Trp Val Val Thr Gly Val Leu Val Tyr 
145                 150                 155                 160 


Leu Ala Val Glu Arg Leu Ile Ser Gly Asp Tyr Glu Ile Asp Gly Gly 
                165                 170                 175     


Thr Met Leu Ile Thr Ser Gly Cys Ala Val Ala Val Asn Ile Ile Met 
            180                 185                 190         


Gly Leu Thr Leu His Gln Ser Gly His Gly His Ser His Gly Thr Thr 
        195                 200                 205             


Asn Gln Gln Glu Glu Asn Pro Ser Val Arg Ala Ala Phe Ile His Val 
    210                 215                 220                 


Ile Gly Asp Phe Met Gln Ser Met Gly Val Leu Val Ala Ala Tyr Ile 
225                 230                 235                 240 


Leu Tyr Phe Lys Pro Glu Tyr Lys Tyr Val Asp Pro Ile Phe Gln Glu 
                245                 250                 255     


Trp Ser Ser Ser Gln Pro Pro Ile 
            260                 


<210>  5620
<211>  2493
<212>  DNA
<213>  Homosapiens

<400>  5620
cggggcgcag cggctgaccc gagacacggg agcgcttggc acgcggagcc agagccggag     60

ctgcagccgc agcgggagcc gggggagctc aggggccgca ggagccgggc cggagtgagc    120

gcacctcgcg gggccctcgg ggcaggtggg tgagcgccac ccggagtccc gcgcgcaact    180

ttcagggcgc actcggcggg gcggctgcgc ggctgccggg actcggcgcg ggactgcatg    240

gaggccaagg agaagcagca tctgttggac gccaggccgg caatccggtc atacacggga    300

tctctgtggc aggaaggggc tggctggatt cctctgcccc gacctggcct ggacttgcag    360

gccattgagc tggctgccca gagcaaccat cactgccatg ctcagaaggg tcctgacagt    420

cactgtgacc ccaagaaggg gaaggcccag cgccagctgt atgtagcctc tgccatctgc    480

ctgttgttca tgatcggaga agtcgttggt gggtacctgg cacacagctt ggctgtcatg    540

actgacgcag cacacctgct cactgacttt gccagcatgc tcatcagcct cttctccctc    600

tggatgtcct cccggccagc caccaagacc atgaactttg gctggcagag agctgagatc    660

ttgggagccc tggtctctgt actgtccatc tgggtcgtga cgggggtact ggtgtacctg    720

gctgtggagc ggctgatctc tggggactat gaaattgacg gggggaccat gctgatcacg    780

tcgggctgcg ctgtggctgt gaacatcata atggggttga cccttcacca gtctggccat    840

gggcacagcc acggcaccac caaccagcag gaggagaacc ccagcgtccg agctgccttc    900

atccatgtga tcggcgactt tatgcagagc atgggtgtcc tagtggcagc ctatatttta    960

tacttcaagc cagaatacaa gtatgtagac cccatctgca ccttcgtctt ctccatcctg   1020

gtcctgggga caaccttgac catcctgaga gatgtgatcc tggtgttgat ggaagggacc   1080

cccaagggcg ttgacttcac agctgttcgt gatctgctgc tgtcggtgga gggggtagaa   1140

gccctgcaca gcctgcatat ctgggcactg acggtggccc agcctgttct gtctgtccac   1200

atcgccattg ctcagaatac agacgcccag gctgtgctga agacagccag cagccgcctc   1260

caagggaagt tccacttcca caccgtgacc atccagatcg aggactactc ggaggacatg   1320

aaggactgtc aggcatgcca gggcccctca gactgactgc tcagccaggc accaactggg   1380

gcatgaacag gacctgcagg tggctggact gagtgtcccc caggcccagc caggactttg   1440

cctaccccag ctgtgttgta aaccaggtcc ccctcctgac ctctgcccca ctccaggaat   1500

ggagctcttc ccagcctccc atctgactac agccagggtg gggactcagc gggtataaag   1560

ctagtgtgac cctgctcttc cagctcctgg gccagctctg gaagggctgt atttgggcct   1620

aatcctcagc aaatgttcta ccactcgcag gggcaaaggt ggtgagccac gggacgtcca   1680

aggggaggct ggccccagcg cgcccatact gcctgcctca tgccccattc tcagcctggc   1740

tggcctttgc ctttatgaat ctgagcccct ccatctgcct atagcaatag gcacgggggt   1800

gaggaccctc acactctcat ttgagcctcc ctgaggcagg gagccaggag gcacctgagg   1860

cctatctgtg ccttagtcac ttcagctatg agccaaatgt tccctttcct ggaggggaga   1920

ggcttcttac taggtaagag acaggtttcc tctttcctta tttcctcagc tgtgccaaca   1980

caaaaaacaa ctttggcaca ggtggtgggc agggggtaga gagatttcag cttgggttct   2040

gcactaacag cctccaagcc ccctggcact tctgttgccc tgagagtgtc ccaggggatt   2100

cagagtctcc agaaagatat ggctgggcca actctgttgc ctacctggcc tgacccagtc   2160

ggagcctgac atggtggagg gaaagggaga caagtggggc tgcactcggt ccagaggcca   2220

gctaggaggg aaaccgcagc ttcctggggc ttgtgtgtga agattcctga cttaggggtg   2280

gcttttgttt acaagatgca agaggggaaa cctgtccccg actcatcgag acaacatgcc   2340

cagttatcag ggagtcctgt gtcacaaggt ctgtctctgc cattgtaagc aagtgccttg   2400

ggcgagctgg cctctgcccc acagtctcat ctgtacaccg acagggttga tgcctccctc   2460

acagggttga gaacaagagc cagttggcca agt                                2493


<210>  5621
<211>  372
<212>  PRT
<213>  Homosapiens

<400>  5621

Met Glu Ala Lys Glu Lys Gln His Leu Leu Asp Ala Arg Pro Ala Ile 
1               5                   10                  15      


Arg Ser Tyr Thr Gly Ser Leu Trp Gln Glu Gly Ala Gly Trp Ile Pro 
            20                  25                  30          


Leu Pro Arg Pro Gly Leu Asp Leu Gln Ala Ile Glu Leu Ala Ala Gln 
        35                  40                  45              


Ser Asn His His Cys His Ala Gln Lys Gly Pro Asp Ser His Cys Asp 
    50                  55                  60                  


Pro Lys Lys Gly Lys Ala Gln Arg Gln Leu Tyr Val Ala Ser Ala Ile 
65                  70                  75                  80  


Cys Leu Leu Phe Met Ile Gly Glu Val Val Gly Gly Tyr Leu Ala His 
                85                  90                  95      


Ser Leu Ala Val Met Thr Asp Ala Ala His Leu Leu Thr Asp Phe Ala 
            100                 105                 110         


Ser Met Leu Ile Ser Leu Phe Ser Leu Trp Met Ser Ser Arg Pro Ala 
        115                 120                 125             


Thr Lys Thr Met Asn Phe Gly Trp Gln Arg Ala Glu Ile Leu Gly Ala 
    130                 135                 140                 


Leu Val Ser Val Leu Ser Ile Trp Val Val Thr Gly Val Leu Val Tyr 
145                 150                 155                 160 


Leu Ala Val Glu Arg Leu Ile Ser Gly Asp Tyr Glu Ile Asp Gly Gly 
                165                 170                 175     


Thr Met Leu Ile Thr Ser Gly Cys Ala Val Ala Val Asn Ile Ile Met 
            180                 185                 190         


Gly Leu Thr Leu His Gln Ser Gly His Gly His Ser His Gly Thr Thr 
        195                 200                 205             


Asn Gln Gln Glu Glu Asn Pro Ser Val Arg Ala Ala Phe Ile His Val 
    210                 215                 220                 


Ile Gly Asp Phe Met Gln Ser Met Gly Val Leu Val Ala Ala Tyr Ile 
225                 230                 235                 240 


Leu Tyr Phe Lys Pro Glu Tyr Lys Tyr Val Asp Pro Ile Cys Thr Phe 
                245                 250                 255     


Val Phe Ser Ile Leu Val Leu Gly Thr Thr Leu Thr Ile Leu Arg Asp 
            260                 265                 270         


Val Ile Leu Val Leu Met Glu Gly Thr Pro Lys Gly Val Asp Phe Thr 
        275                 280                 285             


Ala Val Arg Asp Leu Leu Leu Ser Val Glu Gly Val Glu Ala Leu His 
    290                 295                 300                 


Ser Leu His Ile Trp Ala Leu Thr Val Ala Gln Pro Val Leu Ser Val 
305                 310                 315                 320 


His Ile Ala Ile Ala Gln Asn Thr Asp Ala Gln Ala Val Leu Lys Thr 
                325                 330                 335     


Ala Ser Ser Arg Leu Gln Gly Lys Phe His Phe His Thr Val Thr Ile 
            340                 345                 350         


Gln Ile Glu Asp Tyr Ser Glu Asp Met Lys Asp Cys Gln Ala Cys Gln 
        355                 360                 365             


Gly Pro Ser Asp 
    370         


<210>  5622
<211>  1408
<212>  DNA
<213>  Homosapiens

<400>  5622
gagacacggg agcgcttggc acgcggagcc agagccggag ctgcagccgc agcgggagcc     60

gggggagctc aggggccgca ggagccgggc cggagtgagc gcacctcgcg gggccctcgg    120

ggcaggtggg tgagcgccac ccggagtccc gcgcgcaact ttcagggcgc actcggcggg    180

gcggctgcgc ggctgccggg actcggcgcg ggactgcatg gaggccaagg agaagcagca    240

tctgttggac gccaggccgg caatccggtc atacacggga tctctgtggc aggaaggggc    300

tggctggatt cctctgcccc gacctggcct ggacttgcag gccattgagc tggctgccca    360

gagcaaccat cactgccatg ctcagaaggg tcctgacagt cactgtgacc ccaagaaggg    420

gaaggcccag cgccagctgt atgtagcctc tgccatctgc ctgttgttca tgatcggaga    480

agtcgttgag atcttgggag ccctggtctc tgtactgtcc atctgggtcg tgacgggggt    540

actggtgtac ctggctgtgg agcggctgat ctctggggac tatgaaattg acggggggac    600

catgctgatc acgtcgggct gcgctgtggc tgtgaacatc ataatggggt tgacccttca    660

ccagtctggc catgggcaca gccacggcac caccaaccag caggaggaga accccagcgt    720

ccgagctgcc ttcatccatg tgatcggcga ctttatgcag agcatgggtg tcctagtggc    780

agcctatatt ttatacttca agccagaata caagtatgta gaccccatct gcaccttcgt    840

cttctccatc ctggtcctgg ggacaacctt gaccatcctg agagatgtga tcctggtgtt    900

gatggaaggg acccccaagg gcgttgactt cacagctgtt cgtgatctgc tgctgtcggt    960

ggagggggta gaagccctgc acagcctgca tatctgggca ctgacggtgg cccagcctgt   1020

tctgtctgtc cacatcgcca ttgctcagaa tacagacgcc caggctgtgc tgaagacagc   1080

cagcagccgc ctccaaggga agttccactt ccacaccgtg accatccaga tcgaggacta   1140

ctcggaggac atgaaggact gtcaggcatg ccagggcccc tcagactgac tgctcagcca   1200

ggcaccaact ggggcatgaa caggacctgc aggtggctgg actgagtgtc ccccaggccc   1260

agccaggact ttgcctaccc cagctgtgtt gtaaaccagg tccccctcct gacctctgcc   1320

ccactccagg aatggagctc ttcccagcct cccatctgac tacagccagg gtggggactc   1380

agcgggtata aagctagtgt gaccctgc                                      1408


<210>  5623
<211>  323
<212>  PRT
<213>  Homosapiens

<400>  5623

Met Glu Ala Lys Glu Lys Gln His Leu Leu Asp Ala Arg Pro Ala Ile 
1               5                   10                  15      


Arg Ser Tyr Thr Gly Ser Leu Trp Gln Glu Gly Ala Gly Trp Ile Pro 
            20                  25                  30          


Leu Pro Arg Pro Gly Leu Asp Leu Gln Ala Ile Glu Leu Ala Ala Gln 
        35                  40                  45              


Ser Asn His His Cys His Ala Gln Lys Gly Pro Asp Ser His Cys Asp 
    50                  55                  60                  


Pro Lys Lys Gly Lys Ala Gln Arg Gln Leu Tyr Val Ala Ser Ala Ile 
65                  70                  75                  80  


Cys Leu Leu Phe Met Ile Gly Glu Val Val Glu Ile Leu Gly Ala Leu 
                85                  90                  95      


Val Ser Val Leu Ser Ile Trp Val Val Thr Gly Val Leu Val Tyr Leu 
            100                 105                 110         


Ala Val Glu Arg Leu Ile Ser Gly Asp Tyr Glu Ile Asp Gly Gly Thr 
        115                 120                 125             


Met Leu Ile Thr Ser Gly Cys Ala Val Ala Val Asn Ile Ile Met Gly 
    130                 135                 140                 


Leu Thr Leu His Gln Ser Gly His Gly His Ser His Gly Thr Thr Asn 
145                 150                 155                 160 


Gln Gln Glu Glu Asn Pro Ser Val Arg Ala Ala Phe Ile His Val Ile 
                165                 170                 175     


Gly Asp Phe Met Gln Ser Met Gly Val Leu Val Ala Ala Tyr Ile Leu 
            180                 185                 190         


Tyr Phe Lys Pro Glu Tyr Lys Tyr Val Asp Pro Ile Cys Thr Phe Val 
        195                 200                 205             


Phe Ser Ile Leu Val Leu Gly Thr Thr Leu Thr Ile Leu Arg Asp Val 
    210                 215                 220                 


Ile Leu Val Leu Met Glu Gly Thr Pro Lys Gly Val Asp Phe Thr Ala 
225                 230                 235                 240 


Val Arg Asp Leu Leu Leu Ser Val Glu Gly Val Glu Ala Leu His Ser 
                245                 250                 255     


Leu His Ile Trp Ala Leu Thr Val Ala Gln Pro Val Leu Ser Val His 
            260                 265                 270         


Ile Ala Ile Ala Gln Asn Thr Asp Ala Gln Ala Val Leu Lys Thr Ala 
        275                 280                 285             


Ser Ser Arg Leu Gln Gly Lys Phe His Phe His Thr Val Thr Ile Gln 
    290                 295                 300                 


Ile Glu Asp Tyr Ser Glu Asp Met Lys Asp Cys Gln Ala Cys Gln Gly 
305                 310                 315                 320 


Pro Ser Asp 
            


<210>  5624
<211>  516
<212>  DNA
<213>  Homosapiens

<400>  5624
ccagggtctt cacctcctct ggcctctgaa gggccccggg ccccaggact cccattcccc     60

tatcatcccc gtctgaatac aggcttctca cctctggttt gtcgagctcg gagcgtcctt    120

agctattttt cccagtggac acaaggcctc acagagaaat gggactagag tcggccctcc    180

ttacctcatc tcagagctga gcgttccctc tcttcccctc tggccaggtc atacacggga    240

tctctgtggc aggaaggggc tggctggatt cctctgcccc gacctggcct ggacttgcag    300

gccattgagc tggctgccca gagcaaccat cactgccatg ctcagaaggg tcctgacagt    360

cactgtgacc ccaagaaggg gaaggcccag cgccagctgt atgtagcctc tgccatctgc    420

ctgttgttca tgatcggaga agtcgttggt gggtacctgg cacacagctt ggctgtcatg    480

actgacgcag cacacctgct cactgacttt gccagc                              516


<210>  5625
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  5625

Pro Gln Glu Gly Glu Gly Pro Ala Pro Ala Val Cys Ser Leu Cys His 
1               5                   10                  15      


Leu Pro Val Val His Asp Arg Arg Ser Arg Trp Trp Val Pro Gly Thr 
            20                  25                  30          


Gln Leu Gly Cys His Asp 
        35              


<210>  5626
<211>  1772
<212>  DNA
<213>  Homosapiens

<400>  5626
gacagaattc gggcaccagg agaaggaagc caacaggatc cgacccggtg ttttgtgaca     60

aaggcaagac ccccaggtct acttagagca aagttagtag aggaggcagc taggcgtggc    120

tctcattcct tcccacagaa tggattataa gtcgagcctg atccaggatg ggaatcccat    180

ggagaacttg gagaagcagc tgatctgccc tatctgcctg gagatgttta ccaagccagt    240

ggtcatcttg ccgtgccagc acaacctgtg ccggaagtgt gccaatgaca tcttccaggc    300

tgcaaatccc tactggacca gccggggcag ctcagtgtcc atgtctggag gccgtttccg    360

ctgccccacc tgccgccacg aggtgatcat ggatcgtcac ggagtgtacg gcctgcagag    420

gaacctgctg gtggagaaca tcatcgacat ctacaaacag gagtgctcca gtcggccgct    480

gcagaagggc agtcacccca tgtgcaagga gcacgaagat gagaaaatca acatctactg    540

tctcacgtgt gaggtgccca cctgctccat gtgcaaggtg tttgggatcc acaaggcctg    600

cgaggtggcc ccattgcaga gtgtcttcca gggacaaaag actgaactga ataactgtat    660

ctccatgctg gtggcgggga atgaccgtgt gcagaccatc atcactcagc tggaggattc    720

ccgtcgagtg accaaggaga acagtcacca ggtaaaggaa gagctgagcc agaagtttga    780

cacgttgtat gccatcctgg atgagaagaa aagtgagttg ctgcagcgga tcacgcagga    840

gcaggagaaa aagcttagct tcatcgaggc cctcatccag cagtaccagg agcagctgga    900

caagtccaca aagctggtgg aaactgccat ccagtccctg gacgagcctg ggggagccac    960

cttcctcttg actgccaagc aactcatcaa aagcattgtg gaagcttcca agggctgcca   1020

gctggggaag acagagcagg gctttgagaa catggacttc tttactttgg atttagagca   1080

catagcagac gccctgagag ccattgactt tgggacagat gaggaagagg aagaattcat   1140

tgaagaagaa gatcaggaag aggaagagtc cacagaaggg aaggaagaag gacaccagta   1200

aggagctgga tgaatgagag gcccccagat gcagagagac tggagagggt ggggaggggc   1260

ccagcggcct tggtgacagg cccagggtgg gaggggtcgg ggcccctgga ggggcaatgg   1320

ggaggtgatg tcttctctct gctcagagag cagggactag ggtaggaccc tcaccgctgc   1380

gtccagcaga cactgaacca gaattggaaa cgtgcttgaa acaatcacac aggacacttt   1440

tctacattgg tgcaaaatgg aatattttgt acatttttaa aatgtgattt ttgtatatac   1500

ttgtatatgt atgccaattt ggtgcttttt gtaaaggaac ttttgtataa taatgcctgg   1560

tcgttgggtg acctgcgatt gtcagaaaga ggggaaggaa gccaggttga tacagctgcc   1620

cacttccttt cctgagcagg aggatggggt agcactcaca gggacgatgt gctgtatttc   1680

agtgcctatc ccagacatac ggggtggtaa ctgagtttgt gttatatgtt gttttaataa   1740

atgcacaatg ctctcttcct gttcttcaaa gg                                 1772


<210>  5627
<211>  353
<212>  PRT
<213>  Homosapiens

<400>  5627

Met Asp Tyr Lys Ser Ser Leu Ile Gln Asp Gly Asn Pro Met Glu Asn 
1               5                   10                  15      


Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met Phe Thr Lys 
            20                  25                  30          


Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg Lys Cys Ala 
        35                  40                  45              


Asn Asp Ile Phe Gln Ala Ala Asn Pro Tyr Trp Thr Ser Arg Gly Ser 
    50                  55                  60                  


Ser Val Ser Met Ser Gly Gly Arg Phe Arg Cys Pro Thr Cys Arg His 
65                  70                  75                  80  


Glu Val Ile Met Asp Arg His Gly Val Tyr Gly Leu Gln Arg Asn Leu 
                85                  90                  95      


Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Cys Ser Ser Arg 
            100                 105                 110         


Pro Leu Gln Lys Gly Ser His Pro Met Cys Lys Glu His Glu Asp Glu 
        115                 120                 125             


Lys Ile Asn Ile Tyr Cys Leu Thr Cys Glu Val Pro Thr Cys Ser Met 
    130                 135                 140                 


Cys Lys Val Phe Gly Ile His Lys Ala Cys Glu Val Ala Pro Leu Gln 
145                 150                 155                 160 


Ser Val Phe Gln Gly Gln Lys Thr Glu Leu Asn Asn Cys Ile Ser Met 
                165                 170                 175     


Leu Val Ala Gly Asn Asp Arg Val Gln Thr Ile Ile Thr Gln Leu Glu 
            180                 185                 190         


Asp Ser Arg Arg Val Thr Lys Glu Asn Ser His Gln Val Lys Glu Glu 
        195                 200                 205             


Leu Ser Gln Lys Phe Asp Thr Leu Tyr Ala Ile Leu Asp Glu Lys Lys 
    210                 215                 220                 


Ser Glu Leu Leu Gln Arg Ile Thr Gln Glu Gln Glu Lys Lys Leu Ser 
225                 230                 235                 240 


Phe Ile Glu Ala Leu Ile Gln Gln Tyr Gln Glu Gln Leu Asp Lys Ser 
                245                 250                 255     


Thr Lys Leu Val Glu Thr Ala Ile Gln Ser Leu Asp Glu Pro Gly Gly 
            260                 265                 270         


Ala Thr Phe Leu Leu Thr Ala Lys Gln Leu Ile Lys Ser Ile Val Glu 
        275                 280                 285             


Ala Ser Lys Gly Cys Gln Leu Gly Lys Thr Glu Gln Gly Phe Glu Asn 
    290                 295                 300                 


Met Asp Phe Phe Thr Leu Asp Leu Glu His Ile Ala Asp Ala Leu Arg 
305                 310                 315                 320 


Ala Ile Asp Phe Gly Thr Asp Glu Glu Glu Glu Glu Phe Ile Glu Glu 
                325                 330                 335     


Glu Asp Gln Glu Glu Glu Glu Ser Thr Glu Gly Lys Glu Glu Gly His 
            340                 345                 350         


Gln 
    


<210>  5628
<211>  1118
<212>  DNA
<213>  Homosapiens

<400>  5628
gcacccagcc ccgcgccgcc gccgccgccg ccgtctccgc aactgcaccg cccgcaaaca     60

tggctcagtg actcggagaa aagctgcagt ctccctcccg gcggggcgga cgccaggcct    120

ccttggtcgg gccgcacctc cccgcaggcc cgccaaagag caccgcgccc cgcaggcacc    180

cgagacccgc gcggaagatg caccgggcgt tccaccccag cgagccccgc accccagccc    240

gcagctcgaa acctcgacct tgaagatggt gagtagccag ccaaagtacg atctaatacg    300

ggaggtaggc cgaggtagtt acggtgttgt gtatgaagca gtcatcagaa agacctctgc    360

acgggtggca gtgaagaaaa ttcgatgtca cgcacctgaa aatgttgaac tagcccttcg    420

tgagttctgg gcactaagca gtatcaagag ccaacatcca aatgtgattc acttggagga    480

atgcatccta caaaaggatg ggatggtgca aaagatgtcc cacggctcta attcttccct    540

ttatttacag cttgtagaaa cttcattaaa aggagaaatt gcctttgatc ccagaagcgc    600

ctattatttg tggtttgtga tggatttttg tgacggagga gatatgaatg agtatctgtt    660

gtccaggaaa cccaatcgta aaactaacac cagcttcatg cttcagctga gcagtgccct    720

ggctttcttg cataaaaacc agatcatcca ccgagatctt aagcctgata acatcctgat    780

ttctcaaacc aggttggata ccagtgactt ggaacctacc ctcaaagtgg ctgattttgg    840

tctaagtaaa gtttgttcag cctctgggca gaacccagaa gaacctgtca gtgtaaacaa    900

gtgtttcctt tccacagcat gtggaacaga tttttacatg gctcctgaag tttgggaagg    960

acattacaca gcaaaagctg acatctttgc tctggggatt atcatctggg caatgctgga   1020

aaggatcaca ttcatagaca cagagacaaa gaaggaactc ttggggagtt atgtaaaaca   1080

aggaactgag attgtgcctg ttggggaggc acttctgg                           1118


<210>  5629
<211>  283
<212>  PRT
<213>  Homosapiens

<400>  5629

Met Val Ser Ser Gln Pro Lys Tyr Asp Leu Ile Arg Glu Val Gly Arg 
1               5                   10                  15      


Gly Ser Tyr Gly Val Val Tyr Glu Ala Val Ile Arg Lys Thr Ser Ala 
            20                  25                  30          


Arg Val Ala Val Lys Lys Ile Arg Cys His Ala Pro Glu Asn Val Glu 
        35                  40                  45              


Leu Ala Leu Arg Glu Phe Trp Ala Leu Ser Ser Ile Lys Ser Gln His 
    50                  55                  60                  


Pro Asn Val Ile His Leu Glu Glu Cys Ile Leu Gln Lys Asp Gly Met 
65                  70                  75                  80  


Val Gln Lys Met Ser His Gly Ser Asn Ser Ser Leu Tyr Leu Gln Leu 
                85                  90                  95      


Val Glu Thr Ser Leu Lys Gly Glu Ile Ala Phe Asp Pro Arg Ser Ala 
            100                 105                 110         


Tyr Tyr Leu Trp Phe Val Met Asp Phe Cys Asp Gly Gly Asp Met Asn 
        115                 120                 125             


Glu Tyr Leu Leu Ser Arg Lys Pro Asn Arg Lys Thr Asn Thr Ser Phe 
    130                 135                 140                 


Met Leu Gln Leu Ser Ser Ala Leu Ala Phe Leu His Lys Asn Gln Ile 
145                 150                 155                 160 


Ile His Arg Asp Leu Lys Pro Asp Asn Ile Leu Ile Ser Gln Thr Arg 
                165                 170                 175     


Leu Asp Thr Ser Asp Leu Glu Pro Thr Leu Lys Val Ala Asp Phe Gly 
            180                 185                 190         


Leu Ser Lys Val Cys Ser Ala Ser Gly Gln Asn Pro Glu Glu Pro Val 
        195                 200                 205             


Ser Val Asn Lys Cys Phe Leu Ser Thr Ala Cys Gly Thr Asp Phe Tyr 
    210                 215                 220                 


Met Ala Pro Glu Val Trp Glu Gly His Tyr Thr Ala Lys Ala Asp Ile 
225                 230                 235                 240 


Phe Ala Leu Gly Ile Ile Ile Trp Ala Met Leu Glu Arg Ile Thr Phe 
                245                 250                 255     


Ile Asp Thr Glu Thr Lys Lys Glu Leu Leu Gly Ser Tyr Val Lys Gln 
            260                 265                 270         


Gly Thr Glu Ile Val Pro Val Gly Glu Ala Leu 
        275                 280             


<210>  5630
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  5630
tgactggagg cggcggcagc ggaggcgcga gctgcccgat aatggcggcc tgcagagccc     60

atgagaggga gaagcggcag cgtctaccct gagaaacctc gaccttgaag atggtgagta    120

gccagccaaa gtacgatcta atacgggagg taggccgagg tagttacggt gttgtgtatg    180

aagcagtcat cagaaagacc tctgcacggg tggcagtgaa gaaaattcga tgtcacgcac    240

ctgaaaatgt tgaactagcc cttcgtgagt tctgggcact aagcagtatc aagagccaac    300

atccaaatgt gattcacttg gaggaatgca tcctacaaaa ggatgggatg gtgcaaaaga    360

tgtcccacgg ctctaattct tccctttatt tacagcttgt agaaacttca ttaaaaggag    420

aaattgcctt tgatcccaga agcgcctatt atttgtggtt tgtgatggat ttttgtgacg    480

gaggagatat gaatgagtat ctgttgtcca ggaaacccaa tcgtaaaact aacaccagct    540

tcatgcttca gctgagcagt gccctggctt tcttgcataa aaaccagatc atccaccgag    600

atcttaagcc tgataacatc ctgatttctc aaaccaggtt ggataccagt gacttggaac    660

ctaccctcaa agtggctgat tttggtctaa gtaaagtttg ttcagcctct gggcagaacc    720

cagaagaacc tgtcagtgta aacaagtgtt tcctttccac agcatgtgga acagattttt    780

acatggctcc tgaagtttgg gaaggacatt acacagcaaa agctgacatc tttgctctgg    840

ggattatcat ctgggcaatg ctggaaagga tcacattcat agacacagag acaaagaagg    900

aactcttggg gagttatgta aaacaaggaa ctgagattgt gcctgttggg gaggcacttc    960

tgg                                                                  963


<210>  5631
<211>  283
<212>  PRT
<213>  Homosapiens

<400>  5631

Met Val Ser Ser Gln Pro Lys Tyr Asp Leu Ile Arg Glu Val Gly Arg 
1               5                   10                  15      


Gly Ser Tyr Gly Val Val Tyr Glu Ala Val Ile Arg Lys Thr Ser Ala 
            20                  25                  30          


Arg Val Ala Val Lys Lys Ile Arg Cys His Ala Pro Glu Asn Val Glu 
        35                  40                  45              


Leu Ala Leu Arg Glu Phe Trp Ala Leu Ser Ser Ile Lys Ser Gln His 
    50                  55                  60                  


Pro Asn Val Ile His Leu Glu Glu Cys Ile Leu Gln Lys Asp Gly Met 
65                  70                  75                  80  


Val Gln Lys Met Ser His Gly Ser Asn Ser Ser Leu Tyr Leu Gln Leu 
                85                  90                  95      


Val Glu Thr Ser Leu Lys Gly Glu Ile Ala Phe Asp Pro Arg Ser Ala 
            100                 105                 110         


Tyr Tyr Leu Trp Phe Val Met Asp Phe Cys Asp Gly Gly Asp Met Asn 
        115                 120                 125             


Glu Tyr Leu Leu Ser Arg Lys Pro Asn Arg Lys Thr Asn Thr Ser Phe 
    130                 135                 140                 


Met Leu Gln Leu Ser Ser Ala Leu Ala Phe Leu His Lys Asn Gln Ile 
145                 150                 155                 160 


Ile His Arg Asp Leu Lys Pro Asp Asn Ile Leu Ile Ser Gln Thr Arg 
                165                 170                 175     


Leu Asp Thr Ser Asp Leu Glu Pro Thr Leu Lys Val Ala Asp Phe Gly 
            180                 185                 190         


Leu Ser Lys Val Cys Ser Ala Ser Gly Gln Asn Pro Glu Glu Pro Val 
        195                 200                 205             


Ser Val Asn Lys Cys Phe Leu Ser Thr Ala Cys Gly Thr Asp Phe Tyr 
    210                 215                 220                 


Met Ala Pro Glu Val Trp Glu Gly His Tyr Thr Ala Lys Ala Asp Ile 
225                 230                 235                 240 


Phe Ala Leu Gly Ile Ile Ile Trp Ala Met Leu Glu Arg Ile Thr Phe 
                245                 250                 255     


Ile Asp Thr Glu Thr Lys Lys Glu Leu Leu Gly Ser Tyr Val Lys Gln 
            260                 265                 270         


Gly Thr Glu Ile Val Pro Val Gly Glu Ala Leu 
        275                 280             


<210>  5632
<211>  4293
<212>  DNA
<213>  Homosapiens

<400>  5632
ggaggcggcg gcagcggagg cgcgagctgc ccgataatgg cggcctgcag agcccatgag     60

agggagaagc ggcagcgtct accctgagga aggtgctctt ccccatgggg actgtaccag    120

gctggagagg acatggcact gcttcagaga cacgaaccac cttgagtgga tgtgattggc    180

gatccccgta gagcaggaaa gctcgtctgc tgtgcagccg gcgcagagga ttctgtggca    240

ggaaattaga cactaggaaa ttcagtagcg atttgaagga aacctcgacc ttgaagatgg    300

tgagtagcca gccaaagtac gatctaatac gggaggtagg ccgaggtagt tacggtgttg    360

tgtatgaagc agtcatcaga aagacctctg cacgggtggc agtgaagaaa attcgatgtc    420

acgcacctga aaatgttgaa ctagcccttc gtgagttctg ggcactaagc agtatcaaga    480

gccaacatcc aaatgtgatt cacttggagg aatgcatcct acaaaaggat gggatggtgc    540

aaaagatgtc ccacggctct aattcttccc tttatttaca gcttgtagaa acttcattaa    600

aaggagaaat tgcctttgat cccagaagcg cctattattt gtggtttgtg atggattttt    660

gtgacggagg agatatgaat gagtatctgt tgtccaggaa acccaatcgt aaaactaaca    720

ccagcttcat gcttcagctg agcagtgccc tggctttctt gcataaaaac cagatcatcc    780

accgagatct taagcctgat aacatcctga tttctcaaac caggttggat accagtgact    840

tggaacctac cctcaaagtg gctgattttg gtctaagtaa agtttgttca gcctctgggc    900

agaacccaga agaacctgtc agtgtaaaca agtgtttcct ttccacagca tgtggaacag    960

atttttacat ggctcctgaa gtttgggaag gacattacac agcaaaagct gacatctttg   1020

ctctggggat tatcatctgg gcaatgctgg aaaggatcac attcatagac acagagacaa   1080

agaaggaact cttggggagt tatgtaaaac aaggaactga gattgtgcct gttggggagg   1140

cacttctgga aaatcccaaa atggaacttc tcattcctgt gaagaaaaaa tctatgaatg   1200

ggcgaatgaa acaactgatt aaggaaatgc tggctgcaaa ccctcaggat cgtccagatg   1260

cttttgaact agaactcaga ttagtacaaa ttgcatttaa agatagcagc tgggaaacgt   1320

gacacatatt atttgcaaat accatggatg atatgctgct tctgtttaac agtgatgcaa   1380

cattatgtgg ctgaaaaaga atataaaaag ctagactcta ccctctaagg gtttagattt   1440

tttgtgggat tttttttttc ctcatttttc ttaaatccaa gttggccgtt ttattagtat   1500

gtttcaaatg tgtattacca atgtgggtgt aaatttttaa aaaatgatta ttgatagaag   1560

tttggcagga aaattcttta agagctaaca agagaagaga gtccagtttt ctggaaatat   1620

gtctttaagt attttagaca ttcctcgtca gtattaggaa tttccatggg aaaagaggtt   1680

tgcatgctgg taatgcaacc tttgaaactt tgtaaaggaa acatatatgt atatatttat   1740

gtatatgtaa gtatgtgaat gtgcgcattt tgcattccat atgaaaaaaa tgccacgtct   1800

gtttaaatta tttgatgtag gtttgggttt ttgagatttg ctggtgaagt cagtgacgaa   1860

aaataaacct tcccttatct tcctactctg cccctccccc taatgaaatc atattaagtt   1920

gttttttttt ttttttgtaa tatacagctt tttttttaag gcatcatttt cgagggtcta   1980

aaattatctg gtaaaacaaa tgaaattaag tgatccaaag ctgctgaagt atgtttgaac   2040

tctccagtgc cctatagctg caagagttga attagtcatg cagtcatatg gcagcaggtt   2100

ggtgattcag tccgaccttc tttaggtaac cgagcattta tttaaccaac tataccactg   2160

cattgggacg tctgcacttg agcttctaca atctgatata aatctgaata caggattatt   2220

ctgtttgaaa actttgctat gtgtgaactg taatacttga tacatttttg gtttgaagac   2280

tttgtctaag cctcattata ctgaagttga agaaaccaaa tgagctccac cctcactttg   2340

cctgccctga tatgatcact tgttgagtca ctggagttcc tttcattttg gcactgatgc   2400

tgttttctct tgtctgattt gaaacagtac tggtaataat atggttgttg aaaatgtgat   2460

cacctttatc taaagtggga gaagatacat acacagtatg gcaaatggat aaaatattgt   2520

ggcatcaact acttttaaag tagaaaagct atccatttta tacaatcact gatacagtct   2580

atgtcaaaaa accaacagac cattattcct cttgaagtta gtttgatttt atctttgtat   2640

ggttgtctac aatttgtttt cctgtaaatg cagatagtta aaatctaaag gatagaatgc   2700

tttcctaaaa cagaacatta gcctttaagg ttaaatagac tttacattgt atctaagtta   2760

atctttataa agcactagaa tttttggtca aaagtcaaaa tagtattaga atattgaaat   2820

tattgatagc tttcataatc tcagcttttt tgaacttcca caatttttgg aatatgtcat   2880

aatttttttc cctgtttcaa atgtgttcag aggaaataga atgtaaaaca tcacaaaaaa   2940

aattgcagta cataaaattt ctggactatg ttagttactt gatctggaag tttaaaattt   3000

ggactaaaag gttttattga aataaagcct cttaaaatga aaaatcatat acttttaaca   3060

tcacttttaa gctaataaat ataagaattc ttttggaaat tagaggtgga aacacactgg   3120

aacctcatga taattgaccc tctggatcac cagattagtt taatttaaca gatatgtcca   3180

aggaagttga gctataggga gtaagaaaaa gcatcatgat aacgtctagt caataacatg   3240

gcacttcagc agagattcat agatgatggt atgcccatgc atcatttgct cttcaaatat   3300

ctatgtgctt ggagccacag tttcctaagc gcatagtttt tggtcctgcc tcatgtaaaa   3360

tagttaatga ttatcattta cttggaaaga ttttacctgt gaagtgaaat tctttcattg   3420

ggggtaaggg tatgaggtga tcaggaagtt tcttctggaa ttttatcaag tccttgtatt   3480

ctaaaatagc caagcaaaat gatagtaaat tctttgtctt tgttctttca gtcagaggta   3540

tttattaagt acctactgtg tgctcagcac taaaggtttg ttgataaaat gacaattaaa   3600

aaatggcatt tagccaaagg ccttttcagc caggagtaag aaaagatggt tagtgatatt   3660

tggaaatacc tggatatttg ctagaggaaa aatgaaagca aaacttcgta cacagtgcct   3720

tgcccataat aggtactcaa taagcaattg ttcctcatag agtcttttgc catgatttat   3780

ggtgtttttt gaaatttgtc ttaattgaaa aaagaccaaa tatttcaaat gagcttatag   3840

gcagctgtgg ccagtgaaaa tatggggttg tacagttagt tcctagaatg ttattttgca   3900

ctagttgtca cttagaaaga tggggttcct gtagattttt tggtgctaag ggatactttg   3960

tcattatgat gaagtaagtg ttaagtgtca gataaatagc acacagaata gttctttctg   4020

ctggtctgtt ttttctcttc gttgttgttg tttttaattg taaattgtta tcaatcaaac   4080

tattgtagca gctacaaagt aattcaccag catgacaaaa tggtcaaaaa ataagtcatc   4140

agcacttaag aaatgaaagc aacttttgaa attttctgtt aaaattgtca aatatatttt   4200

atgaagaatt tataaaaggg gaaaatgatt gtaatttatt gttcatgact ttttttttta   4260

aataaagtga gtttcaacaa aaaaaaaact gaa                                4293


<210>  5633
<211>  341
<212>  PRT
<213>  Homosapiens

<400>  5633

Met Val Ser Ser Gln Pro Lys Tyr Asp Leu Ile Arg Glu Val Gly Arg 
1               5                   10                  15      


Gly Ser Tyr Gly Val Val Tyr Glu Ala Val Ile Arg Lys Thr Ser Ala 
            20                  25                  30          


Arg Val Ala Val Lys Lys Ile Arg Cys His Ala Pro Glu Asn Val Glu 
        35                  40                  45              


Leu Ala Leu Arg Glu Phe Trp Ala Leu Ser Ser Ile Lys Ser Gln His 
    50                  55                  60                  


Pro Asn Val Ile His Leu Glu Glu Cys Ile Leu Gln Lys Asp Gly Met 
65                  70                  75                  80  


Val Gln Lys Met Ser His Gly Ser Asn Ser Ser Leu Tyr Leu Gln Leu 
                85                  90                  95      


Val Glu Thr Ser Leu Lys Gly Glu Ile Ala Phe Asp Pro Arg Ser Ala 
            100                 105                 110         


Tyr Tyr Leu Trp Phe Val Met Asp Phe Cys Asp Gly Gly Asp Met Asn 
        115                 120                 125             


Glu Tyr Leu Leu Ser Arg Lys Pro Asn Arg Lys Thr Asn Thr Ser Phe 
    130                 135                 140                 


Met Leu Gln Leu Ser Ser Ala Leu Ala Phe Leu His Lys Asn Gln Ile 
145                 150                 155                 160 


Ile His Arg Asp Leu Lys Pro Asp Asn Ile Leu Ile Ser Gln Thr Arg 
                165                 170                 175     


Leu Asp Thr Ser Asp Leu Glu Pro Thr Leu Lys Val Ala Asp Phe Gly 
            180                 185                 190         


Leu Ser Lys Val Cys Ser Ala Ser Gly Gln Asn Pro Glu Glu Pro Val 
        195                 200                 205             


Ser Val Asn Lys Cys Phe Leu Ser Thr Ala Cys Gly Thr Asp Phe Tyr 
    210                 215                 220                 


Met Ala Pro Glu Val Trp Glu Gly His Tyr Thr Ala Lys Ala Asp Ile 
225                 230                 235                 240 


Phe Ala Leu Gly Ile Ile Ile Trp Ala Met Leu Glu Arg Ile Thr Phe 
                245                 250                 255     


Ile Asp Thr Glu Thr Lys Lys Glu Leu Leu Gly Ser Tyr Val Lys Gln 
            260                 265                 270         


Gly Thr Glu Ile Val Pro Val Gly Glu Ala Leu Leu Glu Asn Pro Lys 
        275                 280                 285             


Met Glu Leu Leu Ile Pro Val Lys Lys Lys Ser Met Asn Gly Arg Met 
    290                 295                 300                 


Lys Gln Leu Ile Lys Glu Met Leu Ala Ala Asn Pro Gln Asp Arg Pro 
305                 310                 315                 320 


Asp Ala Phe Glu Leu Glu Leu Arg Leu Val Gln Ile Ala Phe Lys Asp 
                325                 330                 335     


Ser Ser Trp Glu Thr 
            340     


<210>  5634
<211>  1526
<212>  DNA
<213>  Homosapiens

<400>  5634
gagtgaggtt tggctgccac caaagttact tctagtcctt gctgtccact cctgccctca     60

gtctggacct gcccaaggac ccctgcaatt aggcctccca tgcagaggtc agtgagagcc    120

caagccaatt gctctaggcc ccgtggctgg ctacttatgg ggcactgtcc tgaccagctc    180

tgctaagatg ctcctggccc ctccctccac cccgtccaga ggacggaccc ccagcgccgt    240

ggagaggctg gaagccgaca aagccaagta tgtcaagacg caccaggtga tagctaggcg    300

acaggagcca gccctgcgtg ggagtcctgg gccgctcacg ccgcacccct gcaacgagct    360

ggggccccct gcatcgccca ggacgcccag gccggtccgc cggggaagcg gcaggcggct    420

gccgaggcct gattccctca tcttctaccg ccagaagcgg gactgcaagg cttcggtgaa    480

caaagagaac gccaagggcc agggtctggt gcggcgcctc tttctgggtg ccccgcggga    540

cgctgccccg agcagcccgg cctccacaga gcgacctgcg gcttcagggg gttgggctgc    600

gccccaggat gccccggaag cggcgggaaa gcgggcgctg tgtcccacgt gctcgctgcc    660

cctgtcggag aaggagcgct tcttcaacta ctgcggcctg gagcgcgcgc tggtggaggt    720

gctgggcgca gagcgcttct ccccgcagag ctggggagcc gacgccagcc cgcaggccgg    780

aacttcgccg ccgcccggct ccggggacgc cagcgactgg acatccagcg acaggggcgt    840

ggacagcccg ggcggcgcgg gcggcggcgg cggctcggag gcagcgggct cggcgcggga    900

ccggcgcccc ccggtgtcgg tggtggagcg caacgcgcgc gtcatccagt ggctgtacgg    960

ctgccagcgc gcccgcggac cgccgcgcga gtccgaggtg tgaccgccgc ggctccggac   1020

tggccccggg actggccccg ggcacggaaa aggacacccc tcttctggcg cgctgggtgc   1080

ctttgcgtaa gcccttcctt ctggaactca gtttcgcgtc tgaaccttgg ggaggtggaa   1140

caagttgctg ccgaaggccc ttccctgctc ccgcggcgaa gggggaggga gaggcctctt   1200

ggtccctgtg gagacccggt ctggggagtc acgattgggg tgggagatga gcaaacctgc   1260

tgaataaagt taaaacgtta tttaaatggg gagctgagga aggagcaaac gggttttcgc   1320

ggttaaaccc gtgggttttg gaatgtgtgt tcccggctgt gtgatcctgg gcaagaactt   1380

gacctccctg gacgcagcgg cacccctcgg ttattaagga gggaggagta ggggatagaa   1440

gtatttcaaa atagttgtaa tgcgcatggc aaagtgccca gcatatagaa agtgctcaat   1500

aaacgataac tgctgtgact tctacc                                        1526


<210>  5635
<211>  271
<212>  PRT
<213>  Homosapiens

<400>  5635

Met Leu Leu Ala Pro Pro Ser Thr Pro Ser Arg Gly Arg Thr Pro Ser 
1               5                   10                  15      


Ala Val Glu Arg Leu Glu Ala Asp Lys Ala Lys Tyr Val Lys Thr His 
            20                  25                  30          


Gln Val Ile Ala Arg Arg Gln Glu Pro Ala Leu Arg Gly Ser Pro Gly 
        35                  40                  45              


Pro Leu Thr Pro His Pro Cys Asn Glu Leu Gly Pro Pro Ala Ser Pro 
    50                  55                  60                  


Arg Thr Pro Arg Pro Val Arg Arg Gly Ser Gly Arg Arg Leu Pro Arg 
65                  70                  75                  80  


Pro Asp Ser Leu Ile Phe Tyr Arg Gln Lys Arg Asp Cys Lys Ala Ser 
                85                  90                  95      


Val Asn Lys Glu Asn Ala Lys Gly Gln Gly Leu Val Arg Arg Leu Phe 
            100                 105                 110         


Leu Gly Ala Pro Arg Asp Ala Ala Pro Ser Ser Pro Ala Ser Thr Glu 
        115                 120                 125             


Arg Pro Ala Ala Ser Gly Gly Trp Ala Ala Pro Gln Asp Ala Pro Glu 
    130                 135                 140                 


Ala Ala Gly Lys Arg Ala Leu Cys Pro Thr Cys Ser Leu Pro Leu Ser 
145                 150                 155                 160 


Glu Lys Glu Arg Phe Phe Asn Tyr Cys Gly Leu Glu Arg Ala Leu Val 
                165                 170                 175     


Glu Val Leu Gly Ala Glu Arg Phe Ser Pro Gln Ser Trp Gly Ala Asp 
            180                 185                 190         


Ala Ser Pro Gln Ala Gly Thr Ser Pro Pro Pro Gly Ser Gly Asp Ala 
        195                 200                 205             


Ser Asp Trp Thr Ser Ser Asp Arg Gly Val Asp Ser Pro Gly Gly Ala 
    210                 215                 220                 


Gly Gly Gly Gly Gly Ser Glu Ala Ala Gly Ser Ala Arg Asp Arg Arg 
225                 230                 235                 240 


Pro Pro Val Ser Val Val Glu Arg Asn Ala Arg Val Ile Gln Trp Leu 
                245                 250                 255     


Tyr Gly Cys Gln Arg Ala Arg Gly Pro Pro Arg Glu Ser Glu Val 
            260                 265                 270     


<210>  5636
<211>  512
<212>  DNA
<213>  Homosapiens

<400>  5636
cgtctcaaaa aataaaaata aaaataaaaa aagaaaagaa ggaaaccttt cctgccagcc     60

ggcaggctcc tgccactgcc tccctttcct gcaaggacac acaagttcgc ctattttcat    120

cacaggttcg cacctccaag cctgcatcct tcatgcacct ccttcctttg cctgggttgc    180

cgttcctttt ctctctgttc ttccttctcg gagataacgt atattctcct ccaggaagcc    240

gtcctgaatg cccccagtca gcctcacctg ctctgagctc ccaagtacag tcctattttt    300

gggcctcaat ttgtcacctt ttgtgggacc cgctggtact ctgggttctc tagttaatct    360

ttgacctttt tcctagtaca gggacggcgc acatagtagg gccacaggca cagtttgttg    420

aattaaatga ggctggagag ggcgatggac gcagtcctct ggagctctcc aacttcctgg    480

aaagttgtac cttaaataaa aaacccatcc tg                                  512


<210>  5637
<211>  66
<212>  PRT
<213>  Homosapiens

<400>  5637

Met His Leu Leu Pro Leu Pro Gly Leu Pro Phe Leu Phe Ser Leu Phe 
1               5                   10                  15      


Phe Leu Leu Gly Asp Asn Val Tyr Ser Pro Pro Gly Ser Arg Pro Glu 
            20                  25                  30          


Cys Pro Gln Ser Ala Ser Pro Ala Leu Ser Ser Gln Val Gln Ser Tyr 
        35                  40                  45              


Phe Trp Ala Ser Ile Cys His Leu Leu Trp Asp Pro Leu Val Leu Trp 
    50                  55                  60                  


Val Leu 
65      


<210>  5638
<211>  1300
<212>  DNA
<213>  Homosapiens

<400>  5638
caactgaccc ctgaggcaca ccctctgtgc acctccagat gcaggtagct ggtgagctga     60

aggcagagcc ccggagtctg ctggcaggag ttgtggctac agtgctagct gtcctcggcc    120

tgggtggctc ctgctatgcc gtctggaaga tggtggggca gcggcgggtg ccacgggccc    180

cgtaacgaag aagagagact ctcacttgga tgctgggggg ctcgacgctc agctgcttca    240

gcctgggaga aagaaaaaca ggagttggga gctgaccagg tgagagccct atctgctgag    300

cacccatcca tcaatcctct ccttactcct tcataccttt tcttgtggtc tttggatcgg    360

aagtgggtct tcaggttggt ggaatcgatg aagtacctcc tgtaggaatg gaagtgagaa    420

ggagagtgag gaggtgatag tctcccaagt gcacctatct ccctagccct agcttgtccc    480

tgacgccagg atccgggtct gagaaacggg aggcgggcgg acccacgggt cccaagagag    540

aagactctgc gctgcctggg gcttcaactt cacatctccc ggccggtacc gcggaccctc    600

ctccgcccca ggccgggctc gtccgggact cacgcgcagg ccagacagcg gtgcagaccg    660

ccccctggca ggtcggggtc gaactcggcg tttgggtcgg gctggggtcg tgcggatccc    720

tgaggccgca gctcgcggtg aatctcatcc aagtccggcc gccgccgctt cgccttcatc    780

tgccgggcta gagagtgcgc tcggtgcgcg cctgtccggc gggagcgacc catggccaga    840

aacagcccgg ccggccaagg ggccaggagc agggcaggga gcacacgtgt gagcacttcc    900

gggccgatca gctacgtcag gccacgccgg ggggctaggc aggctcggcc ggaccgcctc    960

tgatgacgtc actctcggcc agcggctcga gcgccgccag gcggccgtcg acgtcagtga   1020

ccgagctcag gacgggctcc cagaagtgtg cccactgaag ggcatggccc cgcgggccct   1080

cgctggggag gcgcggggtg gtgcgtgcgc ctgggggttt cggggccgtc ttgctgccct   1140

gctcttcctg gcctggtcca accagtatca gtgccaacct gtactcctgt catcccttcc   1200

tgtttcccag accttggact ccgcggtggg ggtgggatgc tttatctctg gaaagcactg   1260

ataaatgtct gtgtcatgaa taaattagta aatgactgag                         1300


<210>  5639
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  5639

Met Pro Ser Gly Arg Trp Trp Gly Ser Gly Gly Cys His Gly Pro Arg 
1               5                   10                  15      


Asn Glu Glu Glu Arg Leu Ser Leu Gly Cys Trp Gly Ala Arg Arg Ser 
            20                  25                  30          


Ala Ala Ser Ala Trp Glu Lys Glu Lys Gln Glu Leu Gly Ala Asp Gln 
        35                  40                  45              


Val Arg Ala Leu Ser Ala Glu His Pro Ser Ile Asn Pro Leu Leu Thr 
    50                  55                  60                  


Pro Ser Tyr Leu Phe Leu Trp Ser Leu Asp Arg Lys Trp Val Phe Arg 
65                  70                  75                  80  


Leu Val Glu Ser Met Lys Tyr Leu Leu 
                85                  


<210>  5640
<211>  1124
<212>  DNA
<213>  Homosapiens

<400>  5640
caccatgcga tttcgacgct tgacccctgg ttacttccgg gtgttacaga tgcaggtagc     60

tggtgagctg aaggcagagc cccggagtct gctggcagga gttgtggcta cagtgctagc    120

tgtcctcggc ctgggtggct cctgctatgc cgtctggaag atggtggggc agcggcgggt    180

gccacgggcc ccgtaacgaa gaagagagac tctcacttgg atgctggggg gctcgacgct    240

cagctgcttc agcctgggag aaagaaaaac aggagttggg agctgaccag ccctagcttg    300

tccctgacgc caggatccgg gtctgagaaa cgggaggcgg gcggacccac gggtcccaag    360

agagaagact ctgcgctgcc tggggcttca acttcacatc tcccggccgg taccgcggac    420

cctcctccgc cccaggccgg gctcgtccgg gactcacgcg caggccagac agcggtgcag    480

accgccccct ggcaggtcgg ggtcgaactc ggcgtttggg tcgggctggg gtcgtgcgga    540

tccctgaggc cgcagctcgc ggtgaatctc atccaagtcc ggccgccgcc gcttcgcctt    600

catctgccgg gctagagagt gcgctcggtg cgcgcctgtc cggcgggagc gacccatggc    660

cagaaacagc ccggccggcc aaggggccag gagcagggca gggagcacac gtgtgagcac    720

ttccgggccg atcagctacg tcaggccacg ccggggggct aggcaggctc ggccggaccg    780

cctctgatga cgtcactctc ggccagcggc tcgagcgccg ccaggcggcc gtcgacgtca    840

gtgaccgagc tcaggacggg ctcccagaag tgtgcccact gaagggcatg gccccgcggg    900

ccctcgctgg ggaggcgcgg ggtggtgcgt gcgcctgggg gtttcggggc cgtcttgctg    960

ccctgctctt cctggcctgg tccaaccagt atcagtgcca acctgtactc ctgtcatccc   1020

ttcctgtttc ccagaccttg gactccgcgg tgggggtggg atgctttatc tctggaaagc   1080

actgataaat gtctgtgtca tgaataaatt agtaaatgac tgag                    1124


<210>  5641
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  5641

Met Arg Phe Arg Arg Leu Thr Pro Gly Tyr Phe Arg Val Leu Gln Met 
1               5                   10                  15      


Gln Val Ala Gly Glu Leu Lys Ala Glu Pro Arg Ser Leu Leu Ala Gly 
            20                  25                  30          


Val Val Ala Thr Val Leu Ala Val Leu Gly Leu Gly Gly Ser Cys Tyr 
        35                  40                  45              


Ala Val Trp Lys Met Val Gly Gln Arg Arg Val Pro Arg Ala Pro 
    50                  55                  60              


<210>  5642
<211>  1467
<212>  DNA
<213>  Homosapiens

<400>  5642
ggcaggcgcg ggtgagcatc ctctgagagc ttgggtcttg cgtatgtgga aggtcagaga     60

cccctctacc ctagtttcca cttcttggtg tcatgaagac cactggtctt cacgtccgct    120

cccaccctac aggccgccag ggagaccagt gccgcccacc atgcgatttc gacgcttgac    180

ccctggttac ttccgggtgt tacagatgca ggtagctggt gagctgaagg cagagccccg    240

gagtctgctg gcaggagttg tggctacagt gctagctgtc ctcggcctgg gtggctcctg    300

ctatgccgtc tggaagatgg tggggcagcg gcgggtgcca cgggccccgt aacgaagaag    360

agagactctc acttggatgc tggggggctc gacgctcagc tgcttcagcc tgggagaaag    420

aaaaacagga gttgggagct gaccaggtga gagccctatc tgctgagcac ccatccatca    480

atcctctcct tactccttca taccttttct tgtggtcttt ggatcggaag tgggtcttca    540

ggttggtgga atcgatgaag tacctcctgt aggaatggaa gtgagaagga gagtgaggag    600

gtgatagtct cccaagtgca cctatctccc tagccctagc ttgtccctga cgccaggatc    660

cgggtctgag aaacgggagg cgggcggacc cacgggtccc aagagagaag actctgcgct    720

gcctggggct tcaacttcac atctcccggc cggtaccgcg gaccctcctc cgccccaggc    780

cgggctcgtc cgggactcac gcgcaggcca gacagcggtg cagaccgccc cctggcaggt    840

cggggtcgaa ctcggcgttt gggtcgggct ggggtcgtgc ggatccctga ggccgcagct    900

cgcggtgaat ctcatccaag tccggccgcc gccgcttcgc cttcatctgc cgggctagag    960

agtgcgctcg gtgcgcgcct gtccggcggg agcgacccat ggccagaaac agcccggccg   1020

gccaaggggc caggagcagg gcagggagca cacgtgtgag cacttccggg ccgatcagct   1080

acgtcaggcc acgccggggg gctaggcagg ctcggccgga ccgcctctga tgacgtcact   1140

ctcggccagc ggctcgagcg ccgccaggcg gccgtcgacg tcagtgaccg agctcaggac   1200

gggctcccag aagtgtgccc actgaagggc atggccccgc gggccctcgc tggggaggcg   1260

cggggtggtg cgtgcgcctg ggggtttcgg ggccgtcttg ctgccctgct cttcctggcc   1320

tggtccaacc agtatcagtg ccaacctgta ctcctgtcat cccttcctgt ttcccagacc   1380

ttggactccg cggtgggggt gggatgcttt atctctggaa agcactgata aatgtctgtg   1440

tcatgaataa attagtaaat gactgag                                       1467


<210>  5643
<211>  102
<212>  PRT
<213>  Homosapiens

<400>  5643

Met Trp Lys Val Arg Asp Pro Ser Thr Leu Val Ser Thr Ser Trp Cys 
1               5                   10                  15      


His Glu Asp His Trp Ser Ser Arg Pro Leu Pro Pro Tyr Arg Pro Pro 
            20                  25                  30          


Gly Arg Pro Val Pro Pro Thr Met Arg Phe Arg Arg Leu Thr Pro Gly 
        35                  40                  45              


Tyr Phe Arg Val Leu Gln Met Gln Val Ala Gly Glu Leu Lys Ala Glu 
    50                  55                  60                  


Pro Arg Ser Leu Leu Ala Gly Val Val Ala Thr Val Leu Ala Val Leu 
65                  70                  75                  80  


Gly Leu Gly Gly Ser Cys Tyr Ala Val Trp Lys Met Val Gly Gln Arg 
                85                  90                  95      


Arg Val Pro Arg Ala Pro 
            100         


<210>  5644
<211>  652
<212>  DNA
<213>  Homosapiens

<400>  5644
gtggcctgac gtagctgatc ggcccggaag tgctcacacg tgtgctccct gccctgctcc     60

tggccccttg gccggccggg ctgtttctgg ccatgggtcg ctcccgccgg acaggcgcgc    120

accgagcgca ctctctagcc cggcagatga aggcgaagcg gcggcggccg gacttggatg    180

agattcaccg cgagctgcgg cctcagggat ccgcacgacc ccagcccgac ccaaacgccg    240

agttcgaccc cgacctgcca gggggcggtc tgcaccgctg tctggcctgc gcgaggtact    300

tcatcgattc caccaacctg aagacccact tccgatccaa agaccacaag aaaaggctga    360

agcagctgag cgtcgagccc tacagtcagg aagaggcgga gagggcagcg ggtatgggat    420

cctatgtgcc ccccaggcgg ctggcagtgc ccacggaagt gtccactgag gtccctgaga    480

tggatacctc tacctgacat ggcctgaaga tgcagggcag aggaattgcc catggacagt    540

gacgcaagga ctaggctggg agggagcgtg ccaacccctt ttgcctctgg gtttggggag    600

cggagggcct cttcttggtg ccctgcccca aataaaggaa ctggacaaag ag            652


<210>  5645
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  5645

Met Gly Arg Ser Arg Arg Thr Gly Ala His Arg Ala His Ser Leu Ala 
1               5                   10                  15      


Arg Gln Met Lys Ala Lys Arg Arg Arg Pro Asp Leu Asp Glu Ile His 
            20                  25                  30          


Arg Glu Leu Arg Pro Gln Gly Ser Ala Arg Pro Gln Pro Asp Pro Asn 
        35                  40                  45              


Ala Glu Phe Asp Pro Asp Leu Pro Gly Gly Gly Leu His Arg Cys Leu 
    50                  55                  60                  


Ala Cys Ala Arg Tyr Phe Ile Asp Ser Thr Asn Leu Lys Thr His Phe 
65                  70                  75                  80  


Arg Ser Lys Asp His Lys Lys Arg Leu Lys Gln Leu Ser Val Glu Pro 
                85                  90                  95      


Tyr Ser Gln Glu Glu Ala Glu Arg Ala Ala Gly Met Gly Ser Tyr Val 
            100                 105                 110         


Pro Pro Arg Arg Leu Ala Val Pro Thr Glu Val Ser Thr Glu Val Pro 
        115                 120                 125             


Glu Met Asp Thr Ser Thr 
    130                 


<210>  5646
<211>  674
<212>  DNA
<213>  Homosapiens

<400>  5646
gtggcctgac gtagctgatc ggcccggaag tgctcacacg tgtgctccct gccctgctcc     60

tggccccttg gccggccggg ctgtttctgg ccatgggtcg ctcccgccgg acaggcgcgc    120

accgagcgca ctctctagcc cggcagatga aggcgaagcg gcggcggccg gacttggatg    180

agattcaccg cgagctgcgg cctcagggat ccgcacgacc ccagcccgac ccaaacgccg    240

agttcgaccc cgacctgcca gggggcggtc tgcaccgctg tctggcctgc gcgaggtact    300

tcatcgattc caccaacctg aagacccact tccgatccaa agaccacaag aaaagcgggt    360

atgggatcct atgtgccccc caggcggctg gcagtgccca cggaagtgtc cactgaggtc    420

cctgagatgg atacctctac ctgacatggc ctgaagatgc agggcagagg aattgcccat    480

ggacagtgac gcaaggacta ggctgggagg gagcgtgcca accccttttg cctctgggtt    540

tggggagcgg agggcctctt cttggtgccc tgccccaaat aaaggaactg gacaaagaga    600

acttgcctcc aactctaact tccaggccgc tgtctcaaac tcctgccctg gaagggcttc    660

tctactactt tctg                                                      674


<210>  5647
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  5647

Met Gly Arg Ser Arg Arg Thr Gly Ala His Arg Ala His Ser Leu Ala 
1               5                   10                  15      


Arg Gln Met Lys Ala Lys Arg Arg Arg Pro Asp Leu Asp Glu Ile His 
            20                  25                  30          


Arg Glu Leu Arg Pro Gln Gly Ser Ala Arg Pro Gln Pro Asp Pro Asn 
        35                  40                  45              


Ala Glu Phe Asp Pro Asp Leu Pro Gly Gly Gly Leu His Arg Cys Leu 
    50                  55                  60                  


Ala Cys Ala Arg Tyr Phe Ile Asp Ser Thr Asn Leu Lys Thr His Phe 
65                  70                  75                  80  


Arg Ser Lys Asp His Lys Lys Ser Gly Tyr Gly Ile Leu Cys Ala Pro 
                85                  90                  95      


Gln Ala Ala Gly Ser Ala His Gly Ser Val His 
            100                 105         


<210>  5648
<211>  1064
<212>  DNA
<213>  Homosapiens

<400>  5648
gtggcctgac gtagctgatc ggcccggaag tgctcacacg tgtgctccct gccctgctcc     60

tggccccttg gccggccggg ctgtttctgg ccatgggtcg ctcccgccgg acaggcgcgc    120

accgagcgca ctctctagcc cggcagatga aggcgaagcg gcggcggccg gacttggatg    180

agattcaccg cgagctgcgg cctcagggat ccgcacgacc ccagcccgac ccaaacgccg    240

agttcgaccc cgacctgcca gggggcggtc tgcaccgctg tctggcctgc gcgaggtact    300

tcatcgattc caccaacctg aagacccact tccgatccaa agaccacaag aaaaggctga    360

agcagctgag cgtcgagccc tacagtcagg aagaggcgga gagggcagcg ggtatgggat    420

cctatgtgcc ccccaggcgg ctggcagtgc ccacggaagt gtccactgag gtccctgaga    480

tggatacctc tacctgacat ggcctgaaga tgcagggcag aggaattgcc catggacagt    540

gacgcaagga ctaggctggg agggagcgtg ccaacccctt ttgcctctgg gtttggggag    600

cggagggcct cttcttggtg ccctgcccca aataaaggaa ctggacaaag agaacttgcc    660

tccaactcta acttccaggc cgctgtctca aactcctgcc ctggaagggc ttctctacta    720

ctttctgtac accaggccta gggtgtctac tccccacttg gtctatctct gccttccctc    780

tgaggtccta gcatctgaac tggagcaccc agatggaggc ctgatgcagt gtggggtggc    840

gggagtggga tcagattact ctgtcctgct tctgacagag actgatcccc agaaaagaag    900

gcttctgaga ttgcaccccc ctcccgagtc acctaccccc agcatccaag tgagagtctc    960

tcttcttcgt tacggggccc gtggcacccg ccgctgcccc accatcttcc agacggcata   1020

gcaggagcca cccaggccga ggacagctag cactgtagcc acaa                    1064


<210>  5649
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  5649

Met Gly Arg Ser Arg Arg Thr Gly Ala His Arg Ala His Ser Leu Ala 
1               5                   10                  15      


Arg Gln Met Lys Ala Lys Arg Arg Arg Pro Asp Leu Asp Glu Ile His 
            20                  25                  30          


Arg Glu Leu Arg Pro Gln Gly Ser Ala Arg Pro Gln Pro Asp Pro Asn 
        35                  40                  45              


Ala Glu Phe Asp Pro Asp Leu Pro Gly Gly Gly Leu His Arg Cys Leu 
    50                  55                  60                  


Ala Cys Ala Arg Tyr Phe Ile Asp Ser Thr Asn Leu Lys Thr His Phe 
65                  70                  75                  80  


Arg Ser Lys Asp His Lys Lys Arg Leu Lys Gln Leu Ser Val Glu Pro 
                85                  90                  95      


Tyr Ser Gln Glu Glu Ala Glu Arg Ala Ala Gly Met Gly Ser Tyr Val 
            100                 105                 110         


Pro Pro Arg Arg Leu Ala Val Pro Thr Glu Val Ser Thr Glu Val Pro 
        115                 120                 125             


Glu Met Asp Thr Ser Thr 
    130                 


<210>  5650
<211>  718
<212>  DNA
<213>  Homosapiens

<400>  5650
agtgctcaca cgtgtgctcc ctgccctgct cctggcccct tggccggccg ggctgtttct     60

ggccatgggt cgctcccgcc ggacaggcgc gcaccgagcg cactctctag cccggcagat    120

gaaggcgaag cggcggcggc cggacttgga tgagattcac cgcgagctgc ggcctcaggg    180

atccgcacga ccccagcccg acccaaacgc cgagttcgac cccgacctgc cagggggcgg    240

tctgcaccgc tgtctggcct gcgcgaggta cttcatcgat tccaccaacc tgaagaccca    300

cttccgatcc aaagaccaca agaaaaggta tgaaggagta aggagaggat tgatggatgg    360

gtgctcagca gatagggctc tcacctggtc agctcccaac tcctgttttt ctttctccca    420

ggctgaagca gctgagcgtc gagccctaca gtcaggaaga ggcggagagg gcagcgggta    480

tgggatccta tgtgcccccc aggcggctgg cagtgcccac ggaagtgtcc actgaggtcc    540

ctgagatgga tacctctacc tgacatggcc tgaagatgca gggcagagga attgcccatg    600

gacagtgacg caaggactag gctgggaggg agcgtgccaa ccccttttgc ctctgggttt    660

ggggagcgga gggcctcttc ttggtgccct gccccaaata aaggaactgg acaaagag      718


<210>  5651
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  5651

Met Gly Arg Ser Arg Arg Thr Gly Ala His Arg Ala His Ser Leu Ala 
1               5                   10                  15      


Arg Gln Met Lys Ala Lys Arg Arg Arg Pro Asp Leu Asp Glu Ile His 
            20                  25                  30          


Arg Glu Leu Arg Pro Gln Gly Ser Ala Arg Pro Gln Pro Asp Pro Asn 
        35                  40                  45              


Ala Glu Phe Asp Pro Asp Leu Pro Gly Gly Gly Leu His Arg Cys Leu 
    50                  55                  60                  


Ala Cys Ala Arg Tyr Phe Ile Asp Ser Thr Asn Leu Lys Thr His Phe 
65                  70                  75                  80  


Arg Ser Lys Asp His Lys Lys Arg Tyr Glu Gly Val Arg Arg Gly Leu 
                85                  90                  95      


Met Asp Gly Cys Ser Ala Asp Arg Ala Leu Thr Trp Ser Ala Pro Asn 
            100                 105                 110         


Ser Cys Phe Ser Phe Ser Gln Ala Glu Ala Ala Glu Arg Arg Ala Leu 
        115                 120                 125             


Gln Ser Gly Arg Gly Gly Glu Gly Ser Gly Tyr Gly Ile Leu Cys Ala 
    130                 135                 140                 


Pro Gln Ala Ala Gly Ser Ala His Gly Ser Val His 
145                 150                 155     


<210>  5652
<211>  793
<212>  DNA
<213>  Homosapiens

<400>  5652
agtgctcaca cgtgtgctcc ctgccctgct cctggcccct tggccggccg ggctgtttct     60

ggccatgggt cgctcccgcc ggacaggcgc gcaccgagcg cactctctag cccggcagat    120

gaaggcgaag cggcggcggc cggacttgga tgagattcac cgcgagctgc ggcctcaggg    180

atccgcacga ccccagcccg acccaaacgc cgagttcgac cccgacctgc cagggggcgg    240

tctgcaccgc tgtctggcct gcgcgaggta cttcatcgat tccaccaacc tgaagaccca    300

cttccgatcc aaagaccaca agaaaaggta tgaaggagta aggagaggat tgatggatgg    360

gtgctcagca gatagggctc tcacctggtc agctcccaac tcctgttttt ctttctccca    420

ggctgaagca gctgagcgtc gagccctaca gtcaggaaga ggcggagagg gcagcgggta    480

tgggatccta tgtgcccccc aggcggctgg cagtgcccac ggaagtgtcc actgaggtcc    540

ctgagatgga tacctctacc tgacatggcc tgaagatgca gggcagagga attgcccatg    600

gacagtgacg caaggactag gctgggaggg agcgtgccaa ccccttttgc ctctgggttt    660

ggggagcgga gggcctcttc ttggtgccct gccccaaata aaggaactgg acaaagagaa    720

cttgcctcca actctaactt ccaggccgct gtctcaaact cctgccctgg aagggcttct    780

ctactacttt ctg                                                       793


<210>  5653
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  5653

Met Gly Arg Ser Arg Arg Thr Gly Ala His Arg Ala His Ser Leu Ala 
1               5                   10                  15      


Arg Gln Met Lys Ala Lys Arg Arg Arg Pro Asp Leu Asp Glu Ile His 
            20                  25                  30          


Arg Glu Leu Arg Pro Gln Gly Ser Ala Arg Pro Gln Pro Asp Pro Asn 
        35                  40                  45              


Ala Glu Phe Asp Pro Asp Leu Pro Gly Gly Gly Leu His Arg Cys Leu 
    50                  55                  60                  


Ala Cys Ala Arg Tyr Phe Ile Asp Ser Thr Asn Leu Lys Thr His Phe 
65                  70                  75                  80  


Arg Ser Lys Asp His Lys Lys Arg Tyr Glu Gly Val Arg Arg Gly Leu 
                85                  90                  95      


Met Asp Gly Cys Ser Ala Asp Arg Ala Leu Thr Trp Ser Ala Pro Asn 
            100                 105                 110         


Ser Cys Phe Ser Phe Ser Gln Ala Glu Ala Ala Glu Arg Arg Ala Leu 
        115                 120                 125             


Gln Ser Gly Arg Gly Gly Glu Gly Ser Gly Tyr Gly Ile Leu Cys Ala 
    130                 135                 140                 


Pro Gln Ala Ala Gly Ser Ala His Gly Ser Val His 
145                 150                 155     


<210>  5654
<211>  2542
<212>  DNA
<213>  Homosapiens

<400>  5654
ggagcggaaa ttccggcgac agcagggcaa aacaggagct gattcgagct ggcagagctg     60

ggccatggaa ccggtagaga cctggacccc cggaaaggtg gcaacttggc tgagaggtct    120

tgacgactcc ctgcaggact atccctttga ggactggcag ctgcctggca agaacctgct    180

ccagctctgc ccccaaagcc tcgaggctct ggctgtgcgg tctctgggac accaggagct    240

catcctgggc ggggtggaac agctccaggc cctgagctcc aggctacaga cagagaacct    300

gcaaagcctg acagagggac ttctgggggc aacccatgac ttccagagca tagtccaagg    360

ctgcctgggg gactgtgcca agacccctat tgatgtcctc tgtgcagctg tggagctgtt    420

gcatgaagct gacgccctcc tcttctggct cagcaggtac ctcttctccc acttaaatga    480

tttctcagca tgccaggaga tccgagactt gttggaggag ctgagccagg tcttgcatga    540

ggatggtcca gcggctgaga aggagggcac agtcctgagg atctgcagcc acgtggctgg    600

gatctgccac aacatcctgg tctgctgccc caaggagctg ctggaacaga aggccgtgct    660

cgagcaggtg cagctggaca gtccattggg cctagaaatt cacaccacca gcaattgcca    720

gcactttgtg tcccaagtgg acacccaggt tcccactgac tcccgactgc agatccagcc    780

tggagacgag gttgtccaga tcaacgagca ggtggtggtg ggatggcccc gtaagaacat    840

ggtgagggaa ctgctgcggg agccagccgg actcagctta gtgctgaaga agatcccgat    900

accggagacc cccccacaga cgccccctca ggtcctggac tccccgcacc agaggagccc    960

atcactgtct ctggccccac tgtctcccag ggccccatct gaagacgtct ttgcctttga   1020

cctgtcttca aaccccagtc ccggacccag ccctgcctgg acagactctg cctcccttgg   1080

ccctgagccc ctgcccatcc ccccggaacc cccagccata ctcccagcag gggtagcagg   1140

gactccaggg ctccctgaat cccctgacaa gagtcctgtt ggtcggaaga aatcaaaagg   1200

cctggcgacc cggctgagcc gccggcgggt gtcatgccgt gagctgggcc ggccggactg   1260

tgacggctgg ctcctgttgc gaaaggcacc gggcggcttc atgggcccgc gctggcgccg   1320

ccgctggttt gtgctcaagg gacacacgct ctactggtac cgccagcccc aggatgagaa   1380

ggctgagggc ctcatcaatg tctccaacta tagtctggaa agtggacatg atcagaagaa   1440

gaaatatgtg tttcagctca cccatgatgt gtacaaaccc ttcatcttcg ctgctgatac   1500

cctgacagat ctgagcatgt gggtgcgtca tctcattacc tgcatctcca agtaccagtc   1560

tccaggccgg gcccccccac cccgagagga agactgctac agtgagaccg aagcagagga   1620

cccggacgat gaggctgggt cccactcagc ctcgcccagc cctgctcaag ctgggagtcc   1680

cctccatgga gacacatcac ctgcagccac ccccacacag cgcagcccac ggacctcctt   1740

tggctctctg acagacagca gtgaagaggc actggaagga atggtacggg ggctgaggca   1800

gggtggcgtg tccctcctag gccagccaca gcccctgacc caggaacagt ggcggagctc   1860

tttcatgcgg cgcaaccgag accctcagct caatgagcga gtgcaccgtg tgcgggcgct   1920

acagagcaca ctcaaggcaa agctgcagga gctgcaggtc ctagaagaag tgctgggtga   1980

ccctgagctg acaggagaga agttccgcca gtggaaggag cagaaccggg agctgtactc   2040

agagggcctg ggggcctggg gagtggcaca ggctgaaggc agctcccaca tcttgacctc   2100

tgactccaca gaacagtccc cccactccct gccctctgac cctgaagagc actcccatct   2160

ctgccccctg acctcagaga gcagcctccg acctcctgac ctctgaccct ggccagcact   2220

ctagctcctg acctttgacc cgagggccac ctcaacccca gcttctgacg tgtccaggac   2280

agagcatccc tggattctgt tcagggtggg aagtagtact gctagtcatg gtctcacccc   2340

gagctgaccc ctctgcctgg gctttgtgcc accctctccc ttgccaaaga agaaactctc   2400

cccccaaatc ctccaacctc tggggccaca gccctgcccc tccagttcct tggcagttct   2460

cccccaaacc aggtctgtac aggtgttctt tattttacat gagggctact ttccaaccaa   2520

ataaagtcaa tttttctaag aa                                            2542


<210>  5655
<211>  713
<212>  PRT
<213>  Homosapiens

<400>  5655

Met Glu Pro Val Glu Thr Trp Thr Pro Gly Lys Val Ala Thr Trp Leu 
1               5                   10                  15      


Arg Gly Leu Asp Asp Ser Leu Gln Asp Tyr Pro Phe Glu Asp Trp Gln 
            20                  25                  30          


Leu Pro Gly Lys Asn Leu Leu Gln Leu Cys Pro Gln Ser Leu Glu Ala 
        35                  40                  45              


Leu Ala Val Arg Ser Leu Gly His Gln Glu Leu Ile Leu Gly Gly Val 
    50                  55                  60                  


Glu Gln Leu Gln Ala Leu Ser Ser Arg Leu Gln Thr Glu Asn Leu Gln 
65                  70                  75                  80  


Ser Leu Thr Glu Gly Leu Leu Gly Ala Thr His Asp Phe Gln Ser Ile 
                85                  90                  95      


Val Gln Gly Cys Leu Gly Asp Cys Ala Lys Thr Pro Ile Asp Val Leu 
            100                 105                 110         


Cys Ala Ala Val Glu Leu Leu His Glu Ala Asp Ala Leu Leu Phe Trp 
        115                 120                 125             


Leu Ser Arg Tyr Leu Phe Ser His Leu Asn Asp Phe Ser Ala Cys Gln 
    130                 135                 140                 


Glu Ile Arg Asp Leu Leu Glu Glu Leu Ser Gln Val Leu His Glu Asp 
145                 150                 155                 160 


Gly Pro Ala Ala Glu Lys Glu Gly Thr Val Leu Arg Ile Cys Ser His 
                165                 170                 175     


Val Ala Gly Ile Cys His Asn Ile Leu Val Cys Cys Pro Lys Glu Leu 
            180                 185                 190         


Leu Glu Gln Lys Ala Val Leu Glu Gln Val Gln Leu Asp Ser Pro Leu 
        195                 200                 205             


Gly Leu Glu Ile His Thr Thr Ser Asn Cys Gln His Phe Val Ser Gln 
    210                 215                 220                 


Val Asp Thr Gln Val Pro Thr Asp Ser Arg Leu Gln Ile Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Val Val Gln Ile Asn Glu Gln Val Val Val Gly Trp Pro Arg 
                245                 250                 255     


Lys Asn Met Val Arg Glu Leu Leu Arg Glu Pro Ala Gly Leu Ser Leu 
            260                 265                 270         


Val Leu Lys Lys Ile Pro Ile Pro Glu Thr Pro Pro Gln Thr Pro Pro 
        275                 280                 285             


Gln Val Leu Asp Ser Pro His Gln Arg Ser Pro Ser Leu Ser Leu Ala 
    290                 295                 300                 


Pro Leu Ser Pro Arg Ala Pro Ser Glu Asp Val Phe Ala Phe Asp Leu 
305                 310                 315                 320 


Ser Ser Asn Pro Ser Pro Gly Pro Ser Pro Ala Trp Thr Asp Ser Ala 
                325                 330                 335     


Ser Leu Gly Pro Glu Pro Leu Pro Ile Pro Pro Glu Pro Pro Ala Ile 
            340                 345                 350         


Leu Pro Ala Gly Val Ala Gly Thr Pro Gly Leu Pro Glu Ser Pro Asp 
        355                 360                 365             


Lys Ser Pro Val Gly Arg Lys Lys Ser Lys Gly Leu Ala Thr Arg Leu 
    370                 375                 380                 


Ser Arg Arg Arg Val Ser Cys Arg Glu Leu Gly Arg Pro Asp Cys Asp 
385                 390                 395                 400 


Gly Trp Leu Leu Leu Arg Lys Ala Pro Gly Gly Phe Met Gly Pro Arg 
                405                 410                 415     


Trp Arg Arg Arg Trp Phe Val Leu Lys Gly His Thr Leu Tyr Trp Tyr 
            420                 425                 430         


Arg Gln Pro Gln Asp Glu Lys Ala Glu Gly Leu Ile Asn Val Ser Asn 
        435                 440                 445             


Tyr Ser Leu Glu Ser Gly His Asp Gln Lys Lys Lys Tyr Val Phe Gln 
    450                 455                 460                 


Leu Thr His Asp Val Tyr Lys Pro Phe Ile Phe Ala Ala Asp Thr Leu 
465                 470                 475                 480 


Thr Asp Leu Ser Met Trp Val Arg His Leu Ile Thr Cys Ile Ser Lys 
                485                 490                 495     


Tyr Gln Ser Pro Gly Arg Ala Pro Pro Pro Arg Glu Glu Asp Cys Tyr 
            500                 505                 510         


Ser Glu Thr Glu Ala Glu Asp Pro Asp Asp Glu Ala Gly Ser His Ser 
        515                 520                 525             


Ala Ser Pro Ser Pro Ala Gln Ala Gly Ser Pro Leu His Gly Asp Thr 
    530                 535                 540                 


Ser Pro Ala Ala Thr Pro Thr Gln Arg Ser Pro Arg Thr Ser Phe Gly 
545                 550                 555                 560 


Ser Leu Thr Asp Ser Ser Glu Glu Ala Leu Glu Gly Met Val Arg Gly 
                565                 570                 575     


Leu Arg Gln Gly Gly Val Ser Leu Leu Gly Gln Pro Gln Pro Leu Thr 
            580                 585                 590         


Gln Glu Gln Trp Arg Ser Ser Phe Met Arg Arg Asn Arg Asp Pro Gln 
        595                 600                 605             


Leu Asn Glu Arg Val His Arg Val Arg Ala Leu Gln Ser Thr Leu Lys 
    610                 615                 620                 


Ala Lys Leu Gln Glu Leu Gln Val Leu Glu Glu Val Leu Gly Asp Pro 
625                 630                 635                 640 


Glu Leu Thr Gly Glu Lys Phe Arg Gln Trp Lys Glu Gln Asn Arg Glu 
                645                 650                 655     


Leu Tyr Ser Glu Gly Leu Gly Ala Trp Gly Val Ala Gln Ala Glu Gly 
            660                 665                 670         


Ser Ser His Ile Leu Thr Ser Asp Ser Thr Glu Gln Ser Pro His Ser 
        675                 680                 685             


Leu Pro Ser Asp Pro Glu Glu His Ser His Leu Cys Pro Leu Thr Ser 
    690                 695                 700                 


Glu Ser Ser Leu Arg Pro Pro Asp Leu 
705                 710             


<210>  5656
<211>  581
<212>  DNA
<213>  Homosapiens

<400>  5656
agggcaaaac aggagctgat tcgagctggc agagctgggc catggaaccg gtagagacct     60

ggacccccgg aaaggtggca acttggctga gaggtcttga cgactccctg caggactatc    120

cctttgagga ctggcagctg cctggcaaga acctgctcca gctctgcccc caaagcctcg    180

aggctctggc tgtgcggtct ctgggacacc aggagctcat cctgggcggg gtggaacagc    240

tccaggccct gagctccagg ctacagacag agaacctgca aagcctgaca gagggacttc    300

tgggggcaac ccatgacttc cagagcatag tccaaggctg cctgggggac tgtgccaaga    360

cccctattga tgtcctctgt gcagctgtgg agctgttgca tgaagctgac gccctcctct    420

tctggctcag caggtacccg ggttggggtg acgagtgagg gactattgtc atccttggcc    480

tccttcaggg cgtgggagag aaaaacagat cttggctctt gttcagatat ggtgagccag    540

gcgtggtggc ttaggtctgt aatcccagca ctttgggagg c                        581


<210>  5657
<211>  138
<212>  PRT
<213>  Homosapiens

<400>  5657

Met Glu Pro Val Glu Thr Trp Thr Pro Gly Lys Val Ala Thr Trp Leu 
1               5                   10                  15      


Arg Gly Leu Asp Asp Ser Leu Gln Asp Tyr Pro Phe Glu Asp Trp Gln 
            20                  25                  30          


Leu Pro Gly Lys Asn Leu Leu Gln Leu Cys Pro Gln Ser Leu Glu Ala 
        35                  40                  45              


Leu Ala Val Arg Ser Leu Gly His Gln Glu Leu Ile Leu Gly Gly Val 
    50                  55                  60                  


Glu Gln Leu Gln Ala Leu Ser Ser Arg Leu Gln Thr Glu Asn Leu Gln 
65                  70                  75                  80  


Ser Leu Thr Glu Gly Leu Leu Gly Ala Thr His Asp Phe Gln Ser Ile 
                85                  90                  95      


Val Gln Gly Cys Leu Gly Asp Cys Ala Lys Thr Pro Ile Asp Val Leu 
            100                 105                 110         


Cys Ala Ala Val Glu Leu Leu His Glu Ala Asp Ala Leu Leu Phe Trp 
        115                 120                 125             


Leu Ser Arg Tyr Pro Gly Trp Gly Asp Glu 
    130                 135             


<210>  5658
<211>  1419
<212>  DNA
<213>  Homosapiens

<400>  5658
atgagggata atgaaaaggc ctggtggcag caatggacct cccatacagg cctcgagggg     60

tggggcggga ctcaggagga ccgtatgggg tttggagggg cagtagctgc actgaggggc    120

cgcccctctc ccctgcagag taccattcac gagtcctacg gtcggccaga ggagcaagtg    180

ctcatcaacc gccaggaaat cacgaacaaa gcggacgcct gggacatgca ggagttcatc    240

actcacatgt acatcaagca gctgctccga caccccgcct tccaactgct gctggccctg    300

ctgctggtga tcaatgccat caccatcgct ctccgtacca actcctacct ggaccagaaa    360

cactatgagt tgttctctac catagatgac attgtgctga ccatccttct ttgtgaggtt    420

ctccttggct ggctcaatgg cttctggatt ttctggaagg acggctggaa catcctcaac    480

ttcattatcg tctttatctt gctcttgcgg ttcttcatta atgaaatcaa tattccctcc    540

atcaactaca ctctcagggc gcttcgtctg gtgcatgtgt gcatggcggt ggagcccctc    600

gcccggatca tccgcgtcat cctgcagtcg gtgcctgaca tggccaatat catggtcctc    660

atcctcttct tcatgctggt tttttccgtg tttggagtaa cactctttgg tgcattcgtg    720

cccaagcatt tccagaacat acaggttgcg ctgtacaccc tcttcatctg catcacccag    780

gacggctggg tggacatcta cagtgacttc cagacagaga agagggaata tgcaatggag    840

attgggggtg ccatctactt taccatcttc atcaccatcg gtgccttcat tggcatcaac    900

ctgttcgtca tcgtggtgac caccaacctg gagcaaatga tgaaggcagg agagcaggga    960

caacagcaac gaataacctt tagtgagaca ggcgcagagg aagaggagga gaatgaccag   1020

ctgccactgg tgcattgtgt ggtcgcccgc tcggagaaat ctggtctcct ccaggaaccc   1080

cttgcgggag gccccctgtc gaacctctca gaaaacacgt gtgacaactt ttgcttggtg   1140

cttgaggcaa tacaggagaa cctgaggcag tacaaggaga tccgagatga actcaacatg   1200

attgtggagg aggtgcgcgc aatccgcttc aaccaggagc aggagtcaga ggtgttgaac   1260

aggcgctcgt cgacgagcgg gtcgttggag actacgtcat ccaaggacat ccgccagatg   1320

tctcaacagc aagacttgct cagtgcgctc gttagcatgg aaaaggttca tgactctagc   1380

tcacaaatac tccttaaaaa acacaagagc agccactga                          1419


<210>  5659
<211>  472
<212>  PRT
<213>  Homosapiens

<400>  5659

Met Arg Asp Asn Glu Lys Ala Trp Trp Gln Gln Trp Thr Ser His Thr 
1               5                   10                  15      


Gly Leu Glu Gly Trp Gly Gly Thr Gln Glu Asp Arg Met Gly Phe Gly 
            20                  25                  30          


Gly Ala Val Ala Ala Leu Arg Gly Arg Pro Ser Pro Leu Gln Ser Thr 
        35                  40                  45              


Ile His Glu Ser Tyr Gly Arg Pro Glu Glu Gln Val Leu Ile Asn Arg 
    50                  55                  60                  


Gln Glu Ile Thr Asn Lys Ala Asp Ala Trp Asp Met Gln Glu Phe Ile 
65                  70                  75                  80  


Thr His Met Tyr Ile Lys Gln Leu Leu Arg His Pro Ala Phe Gln Leu 
                85                  90                  95      


Leu Leu Ala Leu Leu Leu Val Ile Asn Ala Ile Thr Ile Ala Leu Arg 
            100                 105                 110         


Thr Asn Ser Tyr Leu Asp Gln Lys His Tyr Glu Leu Phe Ser Thr Ile 
        115                 120                 125             


Asp Asp Ile Val Leu Thr Ile Leu Leu Cys Glu Val Leu Leu Gly Trp 
    130                 135                 140                 


Leu Asn Gly Phe Trp Ile Phe Trp Lys Asp Gly Trp Asn Ile Leu Asn 
145                 150                 155                 160 


Phe Ile Ile Val Phe Ile Leu Leu Leu Arg Phe Phe Ile Asn Glu Ile 
                165                 170                 175     


Asn Ile Pro Ser Ile Asn Tyr Thr Leu Arg Ala Leu Arg Leu Val His 
            180                 185                 190         


Val Cys Met Ala Val Glu Pro Leu Ala Arg Ile Ile Arg Val Ile Leu 
        195                 200                 205             


Gln Ser Val Pro Asp Met Ala Asn Ile Met Val Leu Ile Leu Phe Phe 
    210                 215                 220                 


Met Leu Val Phe Ser Val Phe Gly Val Thr Leu Phe Gly Ala Phe Val 
225                 230                 235                 240 


Pro Lys His Phe Gln Asn Ile Gln Val Ala Leu Tyr Thr Leu Phe Ile 
                245                 250                 255     


Cys Ile Thr Gln Asp Gly Trp Val Asp Ile Tyr Ser Asp Phe Gln Thr 
            260                 265                 270         


Glu Lys Arg Glu Tyr Ala Met Glu Ile Gly Gly Ala Ile Tyr Phe Thr 
        275                 280                 285             


Ile Phe Ile Thr Ile Gly Ala Phe Ile Gly Ile Asn Leu Phe Val Ile 
    290                 295                 300                 


Val Val Thr Thr Asn Leu Glu Gln Met Met Lys Ala Gly Glu Gln Gly 
305                 310                 315                 320 


Gln Gln Gln Arg Ile Thr Phe Ser Glu Thr Gly Ala Glu Glu Glu Glu 
                325                 330                 335     


Glu Asn Asp Gln Leu Pro Leu Val His Cys Val Val Ala Arg Ser Glu 
            340                 345                 350         


Lys Ser Gly Leu Leu Gln Glu Pro Leu Ala Gly Gly Pro Leu Ser Asn 
        355                 360                 365             


Leu Ser Glu Asn Thr Cys Asp Asn Phe Cys Leu Val Leu Glu Ala Ile 
    370                 375                 380                 


Gln Glu Asn Leu Arg Gln Tyr Lys Glu Ile Arg Asp Glu Leu Asn Met 
385                 390                 395                 400 


Ile Val Glu Glu Val Arg Ala Ile Arg Phe Asn Gln Glu Gln Glu Ser 
                405                 410                 415     


Glu Val Leu Asn Arg Arg Ser Ser Thr Ser Gly Ser Leu Glu Thr Thr 
            420                 425                 430         


Ser Ser Lys Asp Ile Arg Gln Met Ser Gln Gln Gln Asp Leu Leu Ser 
        435                 440                 445             


Ala Leu Val Ser Met Glu Lys Val His Asp Ser Ser Ser Gln Ile Leu 
    450                 455                 460                 


Leu Lys Lys His Lys Ser Ser His 
465                 470         


<210>  5660
<211>  1947
<212>  DNA
<213>  Homosapiens

<400>  5660
atggagactg actacttaaa atgtgggtcc tggcagcttc ctagaggaga ggaagatttt     60

gcgggtcaga tgaatgaagt ctggaccatc agcagcacag agaagggcac ccagcggatt    120

ttgctgctgc tgttgctact tactggagat ggcgccctca acctgcctga agcatacaac    180

accagctgct cctccaacct ctccacaaac agcagctcta atgggtccac tgagcagaca    240

acttcaatac aaaaaactca ggaagagaaa ttaaacacaa ctatcagcac aacctccaag    300

ggtacactgc tgccaaattc catcatgact tctacattga aggaccaggg agggatatca    360

agaaccacag ctttatccag cacggcctct tcagttgaga ccccaaaaca gaatcaggaa    420

actccaatta taactccatc agcatcaaac accacagtca atgggacaca atcatcagtg    480

tccattggct ttcaggaatc agacacaatc acatccccaa cagcactgaa cacaccaggc    540

agtgatgttc aatcatctgg gtccatggca accactgtct ctgggaagtc agctataact    600

acatccccaa cagcaaagag cacgccaggc catcatgttc aatcatccgg gtccatggca    660

accactgtct ctgggaagtc agctataact acatccccaa cagcactgaa caaaaccact    720

ggcataaaag aatcttcacc catgacagcc agcgaagtta tgcacactac cttgctaaac    780

acaaccactc tcgggacaac tcttcttgga acaactacat ctgagactca ggaaggaaaa    840

actacagctg catccttatc cccaacaacc acctccatga taagcaagtt gtctggaaca    900

catcataaca cagtctcaca gacaccttcc catctggcag aatcaacctc cagtgttgcc    960

actgctataa tccagtcaca tgagatgaca gctgctcatt ccacaggcct tctccccagg   1020

tcctcggaaa caacaaaatc ctctgctgta actggggcca gtcaaacctc ccctaaacac   1080

acccagagta gtggtcccag agttggagcc tgtgctttgg atgagtatgc aggtagcagg   1140

ggagtttgta tgtgcaatga cagctactac ttccacgcgg aactgtccag ggtgtcggtg   1200

agcctacact gctggccgca gaaaatcgag gtggtcctga gcagctgcat cctgcagact   1260

cgccgctgga tgctgatgaa agatgccttc tcaggatgct ccagcatcag caagatagaa   1320

cagggtctcc gtgtccaggt cttcctgtta gagaagaagg agggtacctg tggacttcgc   1380

ctctctacca acagcagcca cgccctgtac tctctggagg tgcagcttct gcaggttctc   1440

cctggcttca tcagcaatga ctccacaatg ctcagcttca gctgcacgta taccctggtg   1500

gtgaatgtca gccagaccca cccctaccag gtattctcct tcccatatag caccatccat   1560

gttctgggca ctggggacac catcatcatc ttgggcatct tcacagacct tcagctctta   1620

actctgcttg aaaacagaac tgttcctctt ggcatgccct tctacgtagt cctcaagaca   1680

ataagcagtg atttgccctg gtgctgcccc gtcagcaacc ggctgctcca gggcctgcgg   1740

gccaacgggg cctctctgga ggtgaccttg gccttcaacc tgatccgctt ctcgaccagc   1800

gatacactgt acctgcacgg ccgagtgacc ctgtgtgaca cgcgggcaag acgcccatgc   1860

caaccagtga gtgggcagcc ccgggacctc ctgcgcagcc gccgcagcct tgcctgcaaa   1920

gcagttcctg ccgggcaggc tgggtag                                       1947


<210>  5661
<211>  648
<212>  PRT
<213>  Homosapiens

<400>  5661

Met Glu Thr Asp Tyr Leu Lys Cys Gly Ser Trp Gln Leu Pro Arg Gly 
1               5                   10                  15      


Glu Glu Asp Phe Ala Gly Gln Met Asn Glu Val Trp Thr Ile Ser Ser 
            20                  25                  30          


Thr Glu Lys Gly Thr Gln Arg Ile Leu Leu Leu Leu Leu Leu Leu Thr 
        35                  40                  45              


Gly Asp Gly Ala Leu Asn Leu Pro Glu Ala Tyr Asn Thr Ser Cys Ser 
    50                  55                  60                  


Ser Asn Leu Ser Thr Asn Ser Ser Ser Asn Gly Ser Thr Glu Gln Thr 
65                  70                  75                  80  


Thr Ser Ile Gln Lys Thr Gln Glu Glu Lys Leu Asn Thr Thr Ile Ser 
                85                  90                  95      


Thr Thr Ser Lys Gly Thr Leu Leu Pro Asn Ser Ile Met Thr Ser Thr 
            100                 105                 110         


Leu Lys Asp Gln Gly Gly Ile Ser Arg Thr Thr Ala Leu Ser Ser Thr 
        115                 120                 125             


Ala Ser Ser Val Glu Thr Pro Lys Gln Asn Gln Glu Thr Pro Ile Ile 
    130                 135                 140                 


Thr Pro Ser Ala Ser Asn Thr Thr Val Asn Gly Thr Gln Ser Ser Val 
145                 150                 155                 160 


Ser Ile Gly Phe Gln Glu Ser Asp Thr Ile Thr Ser Pro Thr Ala Leu 
                165                 170                 175     


Asn Thr Pro Gly Ser Asp Val Gln Ser Ser Gly Ser Met Ala Thr Thr 
            180                 185                 190         


Val Ser Gly Lys Ser Ala Ile Thr Thr Ser Pro Thr Ala Lys Ser Thr 
        195                 200                 205             


Pro Gly His His Val Gln Ser Ser Gly Ser Met Ala Thr Thr Val Ser 
    210                 215                 220                 


Gly Lys Ser Ala Ile Thr Thr Ser Pro Thr Ala Leu Asn Lys Thr Thr 
225                 230                 235                 240 


Gly Ile Lys Glu Ser Ser Pro Met Thr Ala Ser Glu Val Met His Thr 
                245                 250                 255     


Thr Leu Leu Asn Thr Thr Thr Leu Gly Thr Thr Leu Leu Gly Thr Thr 
            260                 265                 270         


Thr Ser Glu Thr Gln Glu Gly Lys Thr Thr Ala Ala Ser Leu Ser Pro 
        275                 280                 285             


Thr Thr Thr Ser Met Ile Ser Lys Leu Ser Gly Thr His His Asn Thr 
    290                 295                 300                 


Val Ser Gln Thr Pro Ser His Leu Ala Glu Ser Thr Ser Ser Val Ala 
305                 310                 315                 320 


Thr Ala Ile Ile Gln Ser His Glu Met Thr Ala Ala His Ser Thr Gly 
                325                 330                 335     


Leu Leu Pro Arg Ser Ser Glu Thr Thr Lys Ser Ser Ala Val Thr Gly 
            340                 345                 350         


Ala Ser Gln Thr Ser Pro Lys His Thr Gln Ser Ser Gly Pro Arg Val 
        355                 360                 365             


Gly Ala Cys Ala Leu Asp Glu Tyr Ala Gly Ser Arg Gly Val Cys Met 
    370                 375                 380                 


Cys Asn Asp Ser Tyr Tyr Phe His Ala Glu Leu Ser Arg Val Ser Val 
385                 390                 395                 400 


Ser Leu His Cys Trp Pro Gln Lys Ile Glu Val Val Leu Ser Ser Cys 
                405                 410                 415     


Ile Leu Gln Thr Arg Arg Trp Met Leu Met Lys Asp Ala Phe Ser Gly 
            420                 425                 430         


Cys Ser Ser Ile Ser Lys Ile Glu Gln Gly Leu Arg Val Gln Val Phe 
        435                 440                 445             


Leu Leu Glu Lys Lys Glu Gly Thr Cys Gly Leu Arg Leu Ser Thr Asn 
    450                 455                 460                 


Ser Ser His Ala Leu Tyr Ser Leu Glu Val Gln Leu Leu Gln Val Leu 
465                 470                 475                 480 


Pro Gly Phe Ile Ser Asn Asp Ser Thr Met Leu Ser Phe Ser Cys Thr 
                485                 490                 495     


Tyr Thr Leu Val Val Asn Val Ser Gln Thr His Pro Tyr Gln Val Phe 
            500                 505                 510         


Ser Phe Pro Tyr Ser Thr Ile His Val Leu Gly Thr Gly Asp Thr Ile 
        515                 520                 525             


Ile Ile Leu Gly Ile Phe Thr Asp Leu Gln Leu Leu Thr Leu Leu Glu 
    530                 535                 540                 


Asn Arg Thr Val Pro Leu Gly Met Pro Phe Tyr Val Val Leu Lys Thr 
545                 550                 555                 560 


Ile Ser Ser Asp Leu Pro Trp Cys Cys Pro Val Ser Asn Arg Leu Leu 
                565                 570                 575     


Gln Gly Leu Arg Ala Asn Gly Ala Ser Leu Glu Val Thr Leu Ala Phe 
            580                 585                 590         


Asn Leu Ile Arg Phe Ser Thr Ser Asp Thr Leu Tyr Leu His Gly Arg 
        595                 600                 605             


Val Thr Leu Cys Asp Thr Arg Ala Arg Arg Pro Cys Gln Pro Val Ser 
    610                 615                 620                 


Gly Gln Pro Arg Asp Leu Leu Arg Ser Arg Arg Ser Leu Ala Cys Lys 
625                 630                 635                 640 


Ala Val Pro Ala Gly Gln Ala Gly 
                645             


<210>  5662
<211>  1077
<212>  DNA
<213>  Homosapiens

<400>  5662
agttcctgcc gggcaggctg ggtagccgga ctcccagctg cgccgtcttc acggaagcgg     60

tgctgatgcg ggacctgggg gactgcggtg ctggggactg gccagtccta ccgggggcgg    120

ggcttgtgga agactgggcg ggattttgaa gacctaggtc ttgtggatgg tgaactcact    180

tggggcgggg agggaggtgg ggctaccctg gggtcttggg caaagtcctc gcctggccgg    240

cttcgctacc cttgtgcttg cgttgcccac aagcttgtag tcagaagaac tcgcctggga    300

gggatcgctc ctgggagatc cgaacgcggg agggcctgga gcgcggcggc agctggatag    360

cattcgggcc catccgaata agcgctactt gagaggctga ggcagaagga tcgcttgaga    420

ccaggagttt gagggtgcag tgaactatga tggcgccacc acactccagc ctgggagaca    480

gagtgagacc ctgtctctaa aagaaaaaag aaaattcaag atacagagcc agacaggagc    540

ctggatggcc atctttcttc tgatagcaat aagctggatg ctgggataga agcctgatac    600

ctcctccaac cctagtcctt ggcctctagt ttactcgcct gaggcaaggg tagagtggag    660

gaagatttag ggaaagcaag tagtccgttt tattgttacg gaccagagag gttgggggtg    720

cagatgaaac caacatctgg ttggccgggc acggtggctc acacctgtaa tcccagcact    780

ttgggaggcc gaggcgggcg gatcatgaag tcaggagatc gagaccatcc tagctaacac    840

ggtgaaaccc cgtctctact aaaaacacaa aaaatttgcc gggcgtggtg gcgggagcct    900

gtagtctcag ttactcagga ggctgagaca ggagaatggc atgaacccgg gaggcagagg    960

ttgcagtgag ccgagatcgc gccactgcac tccagcctgg gtgacagagc gagactccat   1020

ctcaaaaaaa ataaataaat aaaaataaaa aaaataaaaa ataaaaaatt catttgc      1077


<210>  5663
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  5663

Met Lys Pro Thr Ser Gly Trp Pro Gly Thr Val Ala His Thr Cys Asn 
1               5                   10                  15      


Pro Ser Thr Leu Gly Gly Arg Gly Gly Arg Ile Met Lys Ser Gly Asp 
            20                  25                  30          


Arg Asp His Pro Ser 
        35          


<210>  5664
<211>  3972
<212>  DNA
<213>  Homosapiens

<400>  5664
gacgcgcgtt ctgtggcgcg cggcctggcg ggcgtgcaac ggccgttaga ggagctgagg     60

gagggaacca ccgctcaccg cagacgtggt ggctgcagtc agtcttcccg agtgagggat    120

ttcgccgccc gctttcaggc ccgtttggct taaataactg tgattgatgg ccatgcagga    180

gaaatatcca actgagggga tctctcacgt cacttcaccg agttccgatg tgattcagaa    240

gggcagttcc ctggggactg aatggcagac cccagttatc tcggagccct ttcggagccg    300

cttcagccgc tgttcaagtg tagccgacag tggggacaca gccattggta catcatgctc    360

agatattgcg gaggattttt gcagctcaag tggcagtcct cctttccagc ccatcaaaag    420

ccacgtaacc attccaacag cccatgtgat gccttctact ttagggacct ctcctgccaa    480

gccaaattct acacctgttg gaccctcttc ctctaaactc cctttgtcag ggttggctga    540

aagtgtggga atgacaagaa atggagacct cggtgcaatg aaacattctc caggcctatc    600

tagagatctc atgtatttct ctggtgctac tggagaaaat ggaattgagc agtcctggtt    660

tccagcagtg ggccatgaaa gacaagaaga ggcgaggaag tttgatattc ctagcatgga    720

atctaccctc aatcagtcgg caatgatgga gacactttat tcagatcctc accaccgagt    780

ccgcttccac aacccaagaa ccagcacaag taaggagttg tacagagtgt tgcctgaggc    840

caagaaggca ccgggcagcg gggcagtgtt tgagcggaat ggaccacatt ctaatagcag    900

tggggtcctc cctttgggac tccagcctgc tcccgggctc tccaagcctc tgccctctca    960

ggtgtggcag ccgagtcctg acacttggca tccccgagag caatcttgtg aactcagcac   1020

ttgtcggcag cagctggaat tgattcgttt acagatggag caaatgcagc ttcagaatgg   1080

agccatctgc caccatcctg ctgcttttgg tccttcactg cccatcttag agccagcaca   1140

gtggatcagc atcttgaaca gtaatgaaca ccttctgaag gaaaaagagc ttctcattga   1200

caagcagagg aaacacatct ctcagctgga gcagaaagtg cgagagagcg aactgcaagt   1260

ccacagtgcc ctcttgggcc gccctgcccc ctttggtgat gtctgcttgc tgaggctaca   1320

ggaattgcag cgagaaaaca ctttcttacg tgcacagttt gcacagaaga cagaagcctt   1380

gagcagagaa aagattgacc ttgaaaagaa actctctgct tctgaagttg aagtccagct   1440

catcagagag tcgctcaaag tggcgttgca gaagcattct gaggaagtga agaaacagga   1500

agaaagggtc aaaggtcgtg ataaacatat caataatttg aaaaagaaat gccagaagga   1560

atcagagcag aaccgggaga agcagcagcg tattgagacc ttggagcgct acctggctga   1620

cctgcccaca ctggaagacc atcagaagca gagccagcag cttaaggatt ctgagttgaa   1680

gagcacagag ctgcaggaga aagtgactga gctggagagt ttgctggagg agacccaggc   1740

aatctgcaga gagaaggaga ttcaactgga aagcctgagg cagagagaag cagaattctc   1800

ctccgctgga catagcctgc aagataaaca gtctgtggag gagaccagtg gagaaggtcc   1860

agaagtggaa atggagtcct ggcagaagcg atacgattcg ctccaaaaga ttgtggagaa   1920

gcagcagcag aagatggatc agttgcgctc acaagtacag agcctagagc aggaagtggc   1980

tcaagaagaa ggaacaagcc aggccctgag agaggaggcc cagcgaaggg attcagccct   2040

gcagcagctg cgcacagccg tgaaggagct ttcagtgcaa aaccaggact tgattgagaa   2100

gaatctgaca ctccaggaac acctgcgcca ggcccaacca gggtctccac cttcaccaga   2160

cacggcccag ctggcacttg agctgcacca ggagttggcc agttgccttc aagatctgca   2220

ggctgtctgt agcattgtga cccagagggc ccagggccat gaccccaatc tctccctgct   2280

cctgggcatt cactcagcac agcacccaga gactcagcta gatttgcaga agccagatgt   2340

gatcaagagg aaactagaag aggttcaaca gctgcgtcgt gacattgagg acttaaggac   2400

caccatgtca gacagatatg cccaggacat gggagaaaac tgtgtcacac agtgaggaat   2460

tctgggggat tcccccaggg aggagctggg ctgctgagag cctagtccag caggtttctg   2520

ccctgacatt ctcttgtctg ctattcccag agaggtctca gaggggaggg gagagcctgc   2580

atctgggggc caagggctga ttagggaact gtgtcctacc cacactggca tgttggatta   2640

cgtttgtcct gttaattcac tctagacggt gagttactaa ttaacttttg gcaggtacaa   2700

cagataagtc ctcacaaact gttcccagcc ctaggctgac atgagagacg aacaggctgt   2760

ccacctttct tctccatcca atgggatgga tccatgttca ttcccacttc acaccttggt   2820

cctgctgatt agagagctca tcagaggggc ctggaaaggc tgagcaagta ccagtgacaa   2880

tggccattta agaattctca ggccccatgt gccagccttc ttgggaactg agctggcttt   2940

ctgggttttc tcatgcctgg tcttactgct tcttcctcag ggctcttgtt ctcccagaag   3000

cctcagggta atgtgttggt tagcacgtaa ctactaggat tggggcccta gggattatag   3060

ccaggactct aatctgccta ccatgccatt taacaagaga tcccactctc cagctgcctt   3120

gtgtccctag ggtcctggcc atgtgtttag tgtgctaaac tttctccttt gttctcaggc   3180

cttccaggta gtccccttcc tggacttaag agtgcaaact cttctctgtg gttctagcct   3240

tgggcagaat tatatcccag agaccacaga gcaactgtca agctgcttac cccctcaccc   3300

agggctacag cctgtgccca gccctctaat ttgtgcctct cttgtgttgg gggtggtggg   3360

ggttattcct ttccctttcc tgctctggcc tccttgaaag ttcagagtac ccagtacaag   3420

tcagctttaa agtacagctt ttagtgtttc ctgggttgtt tctctggggc tttagtgagg   3480

gacctttgcc ctctggtttt tcttgcctcc tggtttaggg agcatctcac acttgttagt   3540

atctggttgt tgggccagcc gtgcctcctc tagatctgga gccaggccag gcaggggcca   3600

cgtgtgggcc agtcagccac tacaagattt ttgctaagct ttgggctgtt ggcagcatct   3660

tggacctcat gcctgggcct gaatgaggct ctttcttaag tgtttttaca agtttgtgtt   3720

ttatttatgg agtgacttat cccttccatt cagagcagcc ccacccagcc agcccttcag   3780

cctctgggct cctgctgctt aaaggcagag ccgcctggtt ggtctccacc ctgtgcattg   3840

ggagcccagc caccatgctg acgggtattt ttcctcataa agtttataac cagttattta   3900

tatgaatctt tgttatgtcc atttgtttgt attgcgtatt ttgattataa aataaagtat   3960

cttaacagac tc                                                       3972


<210>  5665
<211>  762
<212>  PRT
<213>  Homosapiens

<400>  5665

Met Ala Met Gln Glu Lys Tyr Pro Thr Glu Gly Ile Ser His Val Thr 
1               5                   10                  15      


Ser Pro Ser Ser Asp Val Ile Gln Lys Gly Ser Ser Leu Gly Thr Glu 
            20                  25                  30          


Trp Gln Thr Pro Val Ile Ser Glu Pro Phe Arg Ser Arg Phe Ser Arg 
        35                  40                  45              


Cys Ser Ser Val Ala Asp Ser Gly Asp Thr Ala Ile Gly Thr Ser Cys 
    50                  55                  60                  


Ser Asp Ile Ala Glu Asp Phe Cys Ser Ser Ser Gly Ser Pro Pro Phe 
65                  70                  75                  80  


Gln Pro Ile Lys Ser His Val Thr Ile Pro Thr Ala His Val Met Pro 
                85                  90                  95      


Ser Thr Leu Gly Thr Ser Pro Ala Lys Pro Asn Ser Thr Pro Val Gly 
            100                 105                 110         


Pro Ser Ser Ser Lys Leu Pro Leu Ser Gly Leu Ala Glu Ser Val Gly 
        115                 120                 125             


Met Thr Arg Asn Gly Asp Leu Gly Ala Met Lys His Ser Pro Gly Leu 
    130                 135                 140                 


Ser Arg Asp Leu Met Tyr Phe Ser Gly Ala Thr Gly Glu Asn Gly Ile 
145                 150                 155                 160 


Glu Gln Ser Trp Phe Pro Ala Val Gly His Glu Arg Gln Glu Glu Ala 
                165                 170                 175     


Arg Lys Phe Asp Ile Pro Ser Met Glu Ser Thr Leu Asn Gln Ser Ala 
            180                 185                 190         


Met Met Glu Thr Leu Tyr Ser Asp Pro His His Arg Val Arg Phe His 
        195                 200                 205             


Asn Pro Arg Thr Ser Thr Ser Lys Glu Leu Tyr Arg Val Leu Pro Glu 
    210                 215                 220                 


Ala Lys Lys Ala Pro Gly Ser Gly Ala Val Phe Glu Arg Asn Gly Pro 
225                 230                 235                 240 


His Ser Asn Ser Ser Gly Val Leu Pro Leu Gly Leu Gln Pro Ala Pro 
                245                 250                 255     


Gly Leu Ser Lys Pro Leu Pro Ser Gln Val Trp Gln Pro Ser Pro Asp 
            260                 265                 270         


Thr Trp His Pro Arg Glu Gln Ser Cys Glu Leu Ser Thr Cys Arg Gln 
        275                 280                 285             


Gln Leu Glu Leu Ile Arg Leu Gln Met Glu Gln Met Gln Leu Gln Asn 
    290                 295                 300                 


Gly Ala Ile Cys His His Pro Ala Ala Phe Gly Pro Ser Leu Pro Ile 
305                 310                 315                 320 


Leu Glu Pro Ala Gln Trp Ile Ser Ile Leu Asn Ser Asn Glu His Leu 
                325                 330                 335     


Leu Lys Glu Lys Glu Leu Leu Ile Asp Lys Gln Arg Lys His Ile Ser 
            340                 345                 350         


Gln Leu Glu Gln Lys Val Arg Glu Ser Glu Leu Gln Val His Ser Ala 
        355                 360                 365             


Leu Leu Gly Arg Pro Ala Pro Phe Gly Asp Val Cys Leu Leu Arg Leu 
    370                 375                 380                 


Gln Glu Leu Gln Arg Glu Asn Thr Phe Leu Arg Ala Gln Phe Ala Gln 
385                 390                 395                 400 


Lys Thr Glu Ala Leu Ser Arg Glu Lys Ile Asp Leu Glu Lys Lys Leu 
                405                 410                 415     


Ser Ala Ser Glu Val Glu Val Gln Leu Ile Arg Glu Ser Leu Lys Val 
            420                 425                 430         


Ala Leu Gln Lys His Ser Glu Glu Val Lys Lys Gln Glu Glu Arg Val 
        435                 440                 445             


Lys Gly Arg Asp Lys His Ile Asn Asn Leu Lys Lys Lys Cys Gln Lys 
    450                 455                 460                 


Glu Ser Glu Gln Asn Arg Glu Lys Gln Gln Arg Ile Glu Thr Leu Glu 
465                 470                 475                 480 


Arg Tyr Leu Ala Asp Leu Pro Thr Leu Glu Asp His Gln Lys Gln Ser 
                485                 490                 495     


Gln Gln Leu Lys Asp Ser Glu Leu Lys Ser Thr Glu Leu Gln Glu Lys 
            500                 505                 510         


Val Thr Glu Leu Glu Ser Leu Leu Glu Glu Thr Gln Ala Ile Cys Arg 
        515                 520                 525             


Glu Lys Glu Ile Gln Leu Glu Ser Leu Arg Gln Arg Glu Ala Glu Phe 
    530                 535                 540                 


Ser Ser Ala Gly His Ser Leu Gln Asp Lys Gln Ser Val Glu Glu Thr 
545                 550                 555                 560 


Ser Gly Glu Gly Pro Glu Val Glu Met Glu Ser Trp Gln Lys Arg Tyr 
                565                 570                 575     


Asp Ser Leu Gln Lys Ile Val Glu Lys Gln Gln Gln Lys Met Asp Gln 
            580                 585                 590         


Leu Arg Ser Gln Val Gln Ser Leu Glu Gln Glu Val Ala Gln Glu Glu 
        595                 600                 605             


Gly Thr Ser Gln Ala Leu Arg Glu Glu Ala Gln Arg Arg Asp Ser Ala 
    610                 615                 620                 


Leu Gln Gln Leu Arg Thr Ala Val Lys Glu Leu Ser Val Gln Asn Gln 
625                 630                 635                 640 


Asp Leu Ile Glu Lys Asn Leu Thr Leu Gln Glu His Leu Arg Gln Ala 
                645                 650                 655     


Gln Pro Gly Ser Pro Pro Ser Pro Asp Thr Ala Gln Leu Ala Leu Glu 
            660                 665                 670         


Leu His Gln Glu Leu Ala Ser Cys Leu Gln Asp Leu Gln Ala Val Cys 
        675                 680                 685             


Ser Ile Val Thr Gln Arg Ala Gln Gly His Asp Pro Asn Leu Ser Leu 
    690                 695                 700                 


Leu Leu Gly Ile His Ser Ala Gln His Pro Glu Thr Gln Leu Asp Leu 
705                 710                 715                 720 


Gln Lys Pro Asp Val Ile Lys Arg Lys Leu Glu Glu Val Gln Gln Leu 
                725                 730                 735     


Arg Arg Asp Ile Glu Asp Leu Arg Thr Thr Met Ser Asp Arg Tyr Ala 
            740                 745                 750         


Gln Asp Met Gly Glu Asn Cys Val Thr Gln 
        755                 760         


<210>  5666
<211>  4256
<212>  DNA
<213>  Homosapiens

<400>  5666
gacgcgcgtt ctgtggcgcg cggcctggcg ggcgtgcaac ggccgttaga ggagctgagg     60

gagggaacca ccgctcaccg cagacgtggt ggctgcagtc agtcttcccg agtgagggat    120

ttcgccgccc gctttcaggc ccgtttggct taaataactg tgattgatgg ccatgcagga    180

gaaatatcca actgagggga tctctcacgt cacttcaccg agttccgatg tgattcagaa    240

gggcagttcc ctggggactg aatggcagac cccagttatc tcggagccct ttcggagccg    300

cttcagccgc tgttcaagtg tagccgacag tggggacaca gccattggta catcatgctc    360

agatattgcg gaggattttt gcagctcaag tggcagtcct cctttccagc ccatcaaaag    420

ccacgtaacc attccaacag cccatgtgat gccttctact ttagggacct ctcctgccaa    480

gccaaattct acacctgttg gaccctcttc ctctaaactc cctttgtcag ggttggctga    540

aagtgtggga atgacaagaa atggagacct cggtgcaatg aaacattctc caggcctatc    600

tagagatctc atgtatttct ctggtgctac tggagaaaat ggaattgagc agtcctggtt    660

tccagcagtg ggccatgaaa gacaagaaga ggcgaggaag tttgatattc ctagcatgga    720

atctaccctc aatcagtcgg caatgatgga gacactttat tcagatcctc accaccgagt    780

ccgcttccac aacccaagaa ccagcacaag taaggagttg tacagagtgt tgcctgaggc    840

caagaaggca ccgggcagcg gggcagtgtt tgagcggaat ggaccacatt ctaatagcag    900

tggggtcctc cctttgggac tccagcctgc tcccgggctc tccaagcctc tgccctctca    960

ggtgtggcag ccgagtcctg acacttggca tccccgagag caatcttgtg aactcagcac   1020

ttgtcggcag cagctggaat tgattcgttt acagatggag caaatgcagc ttcagaatgg   1080

agccatctgc caccatcctg ctgcttttgg tccttcactg cccatcttag agccagcaca   1140

gtggatcagc atcttgaaca gtaatgaaca ccttctgaag gaaaaagagc ttctcattga   1200

caagcagagg aaacacatct ctcagctgga gcagaaagtg cgagagagcg aactgcaagt   1260

ccacagtgcc ctcttgggcc gccctgcccc ctttggtgat gtctgcttgc tgaggctaca   1320

ggaattgcag cgagaaaaca ctttcttacg tgcacagttt gcacagaaga cagaagcctt   1380

gagcagagaa aagattgacc ttgaaaagaa actctctgct tctgaagttg aagtccagct   1440

catcagagag tcgctcaaag tggcgttgca gaagcattct gaggaagtga agaaacagga   1500

agaaagggtc aaaggtcgtg ataaacatat caataatttg aaaaagaaat gccagaagga   1560

atcagagcag aaccgggaga agcagcagcg tattgagacc ttggagcgct acctggctga   1620

cctgcccaca ctggaagacc atcagaagca gagccagcag cttaaggatt ctgagttgaa   1680

gagcacagag ctgcaggaga aagtgactga gctggagagt ttgctggagg agacccaggc   1740

aatctgcaga gagaaggaga ttcaactgga aagcctgagg cagagagaag cagaattctc   1800

ctccgctgga catagcctgc aagataaaca gtctgtggag gagaccagtg gagaaggtcc   1860

agaagtggaa atggagtcct ggcagaagcg atacgattcg ctccaaaaga ttgtggagaa   1920

gcagcagcag aagatggatc agttgcgctc acaagtacag agcctagagc aggaagtggc   1980

tcaagaagaa ggaacaagcc aggccctgag agaggaggcc cagcgaaggg attcagccct   2040

gcagcagctg cgcacagccg tgaaggagct ttcagtgcaa aaccaggact tgattgagaa   2100

gaatctgaca ctccaggaac acctgcgcca ggcccaacca gggtctccac cttcaccaga   2160

cacggcccag ctggcacttg agctgcacca ggagttggcc agttgccttc aagatctgca   2220

ggctgtctgt agcattgtga cccagagggc ccagggccat gaccccaatc tctccctgct   2280

cctgggcatt cactcagcac agcacccaga gactcagcta gatttgcaga agccagatgt   2340

gatcaagagg aaactagaag aggttcaaca gctgcgtcgt gacattgagg acttaaggac   2400

caccatgtca gacagatatg cccaggacat gggagaaaac tgtgtcacac agtgaggaat   2460

tctgggggat tcccccaggg aggagctggg ctgctgagag cctagtccag caggtttctg   2520

ccctgacatt ctcttgtctg ctattcccag agaggtctca gaggggaggg gagagcctgc   2580

atctgggggc caagggctga ttagggaact gtgtcctacc cacactggca tgttggatta   2640

cgtttgtcct gttaattcac tctagacggt gagttactaa ttaacttttg gcaggtacaa   2700

cagataagtc ctcacaaact gttcccagcc ctaggctgac atgagagacg aacaggctgt   2760

ccacctttct tctccatcca atgggatgga tccatgttca ttcccacttc acaccttggt   2820

cctgctgatt agagagctca tcagaggggc ctggaaaggc tgagcaagta ccagtgacaa   2880

tggccattta agaattctca ggccccatgt gccagccttc ttgggaactg agctggcttt   2940

ctgggttttc tcatgcctgg tcttactgct tcttcctcag ggctcttgtt ctcccagaag   3000

cctcagggta atgtgttggt tagcacgtaa ctactaggat tggggcccta gggattatag   3060

ccaggactct aatctgccta ccatgccatt taacaagaga tcccactctc cagctgcctt   3120

gtgtccctag ggtcctggcc atgtgtttag tgtgctaaac tttctccttt gttctcaggc   3180

cttccaggta gtccccttcc tggacttaag agtgcaaact cttctctgtg gttctagcct   3240

tgggcagaat tatatcccag agaccacaga gcaactgtca agctgcttac cccctcaccc   3300

agggctacag cctgtgccca gccctctaat ttgtgcctct cttgtgttgg gggtggtggg   3360

ggttattcct ttccctttcc tgctctggcc tccttgaaag ttcagagtac ccagtacaac   3420

ccagccacca tgctgacggg tatttttcct cataaagttt ataaccagtt atttatatga   3480

atctttgtta tgtccatttg tttgtattgc gtattttgat tataaaataa agtatcttaa   3540

cagactcctc agttttccat acccttccat caccaccacc acgctattct acccctcact   3600

ttggcttgtt agagccaaac acctgggtgt tcagccaggt cccccaggca gcagcgtgga   3660

ggaacctttg gcaggtccag ccagcctcat gtccctatct atctctgcca cctctgctcc   3720

tctgtcgttc tatagaacca gatctcttcc cactcacttt ctcttgggca aaccttccct   3780

gagtcataac agaagtttgt cactggaaag tttcagcagt cctctcagga agttggcagc   3840

ctctgggttg ctgtgaggaa gtggctttac cagagcaagg gttgtctttc tgggctgtta   3900

acctgcctga gccctggacc agggggacat ctgagaagca tgatgttgag tgccagacag   3960

ctaggtctcc aaagttgggc tcgttgctgg agtctgcccc ctcaaccgct gaattcttgc   4020

tgggagtagt agcagtttgg gaatgccatc tgcagcatgg agctggggtt gagcttggac   4080

caccccaaga cctggggtgg atcttaaggg tcagcttgag cctaggctct cgagtcctga   4140

catcatcctc taccgccacg ctttccagct gtcagccttg gtctccatct ggttccttga   4200

gggtgtggcc tctgcgtcct gctatcaccc ttccttgtct aaaccttccc acctga       4256


<210>  5667
<211>  762
<212>  PRT
<213>  Homosapiens

<400>  5667

Met Ala Met Gln Glu Lys Tyr Pro Thr Glu Gly Ile Ser His Val Thr 
1               5                   10                  15      


Ser Pro Ser Ser Asp Val Ile Gln Lys Gly Ser Ser Leu Gly Thr Glu 
            20                  25                  30          


Trp Gln Thr Pro Val Ile Ser Glu Pro Phe Arg Ser Arg Phe Ser Arg 
        35                  40                  45              


Cys Ser Ser Val Ala Asp Ser Gly Asp Thr Ala Ile Gly Thr Ser Cys 
    50                  55                  60                  


Ser Asp Ile Ala Glu Asp Phe Cys Ser Ser Ser Gly Ser Pro Pro Phe 
65                  70                  75                  80  


Gln Pro Ile Lys Ser His Val Thr Ile Pro Thr Ala His Val Met Pro 
                85                  90                  95      


Ser Thr Leu Gly Thr Ser Pro Ala Lys Pro Asn Ser Thr Pro Val Gly 
            100                 105                 110         


Pro Ser Ser Ser Lys Leu Pro Leu Ser Gly Leu Ala Glu Ser Val Gly 
        115                 120                 125             


Met Thr Arg Asn Gly Asp Leu Gly Ala Met Lys His Ser Pro Gly Leu 
    130                 135                 140                 


Ser Arg Asp Leu Met Tyr Phe Ser Gly Ala Thr Gly Glu Asn Gly Ile 
145                 150                 155                 160 


Glu Gln Ser Trp Phe Pro Ala Val Gly His Glu Arg Gln Glu Glu Ala 
                165                 170                 175     


Arg Lys Phe Asp Ile Pro Ser Met Glu Ser Thr Leu Asn Gln Ser Ala 
            180                 185                 190         


Met Met Glu Thr Leu Tyr Ser Asp Pro His His Arg Val Arg Phe His 
        195                 200                 205             


Asn Pro Arg Thr Ser Thr Ser Lys Glu Leu Tyr Arg Val Leu Pro Glu 
    210                 215                 220                 


Ala Lys Lys Ala Pro Gly Ser Gly Ala Val Phe Glu Arg Asn Gly Pro 
225                 230                 235                 240 


His Ser Asn Ser Ser Gly Val Leu Pro Leu Gly Leu Gln Pro Ala Pro 
                245                 250                 255     


Gly Leu Ser Lys Pro Leu Pro Ser Gln Val Trp Gln Pro Ser Pro Asp 
            260                 265                 270         


Thr Trp His Pro Arg Glu Gln Ser Cys Glu Leu Ser Thr Cys Arg Gln 
        275                 280                 285             


Gln Leu Glu Leu Ile Arg Leu Gln Met Glu Gln Met Gln Leu Gln Asn 
    290                 295                 300                 


Gly Ala Ile Cys His His Pro Ala Ala Phe Gly Pro Ser Leu Pro Ile 
305                 310                 315                 320 


Leu Glu Pro Ala Gln Trp Ile Ser Ile Leu Asn Ser Asn Glu His Leu 
                325                 330                 335     


Leu Lys Glu Lys Glu Leu Leu Ile Asp Lys Gln Arg Lys His Ile Ser 
            340                 345                 350         


Gln Leu Glu Gln Lys Val Arg Glu Ser Glu Leu Gln Val His Ser Ala 
        355                 360                 365             


Leu Leu Gly Arg Pro Ala Pro Phe Gly Asp Val Cys Leu Leu Arg Leu 
    370                 375                 380                 


Gln Glu Leu Gln Arg Glu Asn Thr Phe Leu Arg Ala Gln Phe Ala Gln 
385                 390                 395                 400 


Lys Thr Glu Ala Leu Ser Arg Glu Lys Ile Asp Leu Glu Lys Lys Leu 
                405                 410                 415     


Ser Ala Ser Glu Val Glu Val Gln Leu Ile Arg Glu Ser Leu Lys Val 
            420                 425                 430         


Ala Leu Gln Lys His Ser Glu Glu Val Lys Lys Gln Glu Glu Arg Val 
        435                 440                 445             


Lys Gly Arg Asp Lys His Ile Asn Asn Leu Lys Lys Lys Cys Gln Lys 
    450                 455                 460                 


Glu Ser Glu Gln Asn Arg Glu Lys Gln Gln Arg Ile Glu Thr Leu Glu 
465                 470                 475                 480 


Arg Tyr Leu Ala Asp Leu Pro Thr Leu Glu Asp His Gln Lys Gln Ser 
                485                 490                 495     


Gln Gln Leu Lys Asp Ser Glu Leu Lys Ser Thr Glu Leu Gln Glu Lys 
            500                 505                 510         


Val Thr Glu Leu Glu Ser Leu Leu Glu Glu Thr Gln Ala Ile Cys Arg 
        515                 520                 525             


Glu Lys Glu Ile Gln Leu Glu Ser Leu Arg Gln Arg Glu Ala Glu Phe 
    530                 535                 540                 


Ser Ser Ala Gly His Ser Leu Gln Asp Lys Gln Ser Val Glu Glu Thr 
545                 550                 555                 560 


Ser Gly Glu Gly Pro Glu Val Glu Met Glu Ser Trp Gln Lys Arg Tyr 
                565                 570                 575     


Asp Ser Leu Gln Lys Ile Val Glu Lys Gln Gln Gln Lys Met Asp Gln 
            580                 585                 590         


Leu Arg Ser Gln Val Gln Ser Leu Glu Gln Glu Val Ala Gln Glu Glu 
        595                 600                 605             


Gly Thr Ser Gln Ala Leu Arg Glu Glu Ala Gln Arg Arg Asp Ser Ala 
    610                 615                 620                 


Leu Gln Gln Leu Arg Thr Ala Val Lys Glu Leu Ser Val Gln Asn Gln 
625                 630                 635                 640 


Asp Leu Ile Glu Lys Asn Leu Thr Leu Gln Glu His Leu Arg Gln Ala 
                645                 650                 655     


Gln Pro Gly Ser Pro Pro Ser Pro Asp Thr Ala Gln Leu Ala Leu Glu 
            660                 665                 670         


Leu His Gln Glu Leu Ala Ser Cys Leu Gln Asp Leu Gln Ala Val Cys 
        675                 680                 685             


Ser Ile Val Thr Gln Arg Ala Gln Gly His Asp Pro Asn Leu Ser Leu 
    690                 695                 700                 


Leu Leu Gly Ile His Ser Ala Gln His Pro Glu Thr Gln Leu Asp Leu 
705                 710                 715                 720 


Gln Lys Pro Asp Val Ile Lys Arg Lys Leu Glu Glu Val Gln Gln Leu 
                725                 730                 735     


Arg Arg Asp Ile Glu Asp Leu Arg Thr Thr Met Ser Asp Arg Tyr Ala 
            740                 745                 750         


Gln Asp Met Gly Glu Asn Cys Val Thr Gln 
        755                 760         


<210>  5668
<211>  561
<212>  DNA
<213>  Homosapiens

<400>  5668
ctatacaagg ttcacatttc tacctatttc caactttcaa gtactactct gagggggact     60

actgcaagca aacaataagg gaggaatgtg aggtaacata cttattgctt tcagcaggca    120

gaaaactgaa taaggaaata aggaatacca atttcttctc ttttcaacta tattcagtac    180

tcgttcccaa atcaagcata tctaccacgg agaagagcga ctaccaactt gtttcttttt    240

ctccccagca accaacacag agaacactca gataacaaca acaaatacta taattgttcc    300

cagaattatg taagtataga tcagctacga ccttctcatt aaacaacttt tttttttgaa    360

atgggtctca aaacaaacac acaaaaagag ttaagattag gatcatggta tgtaacaaac    420

atagcagttt aaaaaatgtc taggcctggg cgtggtggct cacgcctgta atcccagcac    480

tttgagaagc cgaggtgggc agatcgtgag gtcaggagat cgagaccatt ctggctaaca    540

cggtgaaacc ccgtctctac t                                              561


<210>  5669
<211>  90
<212>  PRT
<213>  Homosapiens

<400>  5669

Ile Gln Gly Ser His Phe Tyr Leu Phe Pro Thr Phe Lys Tyr Tyr Ser 
1               5                   10                  15      


Glu Gly Asp Tyr Cys Lys Gln Thr Ile Arg Glu Glu Cys Glu Val Thr 
            20                  25                  30          


Tyr Leu Leu Leu Ser Ala Gly Arg Lys Leu Asn Lys Glu Ile Arg Asn 
        35                  40                  45              


Thr Asn Phe Phe Ser Phe Gln Leu Tyr Ser Val Leu Val Pro Lys Ser 
    50                  55                  60                  


Ser Ile Ser Thr Thr Glu Lys Ser Asp Tyr Gln Leu Val Ser Phe Ser 
65                  70                  75                  80  


Pro Gln Gln Pro Thr Gln Arg Thr Leu Arg 
                85                  90  


<210>  5670
<211>  435
<212>  DNA
<213>  Homosapiens

<400>  5670
agtcaggttt ggggtatggg agagagaaca gaatcctgcc tcagatgcca tactccctgt     60

cctgcatact gagcaagact gtctagttcg cttcattctt cagatagttt ggactcgttg    120

ctcaccttcc tgggggagct tttggaggtc gcagaagatt ctggtgactc ttggaaagga    180

tatttttatt agatttgatt atagctgaga gttgtccagc ttccagaaga gtaggaccta    240

actcattttc cttaaatttt tgcagctcaa gtggcagtcc tcctttccag cccatcaaaa    300

gccacgtaac cattccaaca gcccatgtga tgccttctac tttagggacc tctcctgcca    360

agccaaattc tacacctgtt ggaccctctt cctctaaact ccctttgtca gggttggctg    420

aaagtgtggg aatga                                                     435


<210>  5671
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  5671

Met Pro Ser Thr Leu Gly Thr Ser Pro Ala Lys Pro Asn Ser Thr Pro 
1               5                   10                  15      


Val Gly Pro Ser Ser Ser Lys Leu Pro Leu Ser Gly Leu Ala Glu Ser 
            20                  25                  30          


Val Gly 
        


<210>  5672
<211>  570
<212>  DNA
<213>  Homosapiens

<400>  5672
ggaccaaaag cagcaggatg gtggcagatg gctccattct gaagctgaaa ggcaagtagg     60

cccagatgag cttgatcttg acccatacac gcctgaaaac acctgagcag taatcagctg    120

ggtctgtagt caaagcccaa cttggctcag cctgatgagg cccaatgttt atgaaataat    180

tttagctctg aggcatgact ggaaagaacc tgccaggaag gcttctgcca actgaacact    240

ccctgttcaa aaaggctcta gtttctaaga aaaggtcagt tatcttttat tatctagcaa    300

cagaggcaaa ccaggagcta ggatgtcctc accaaccaag gaaggggaat atgtctgctc    360

ccttccttcc cactcttcag cagcacaagg attttttaaa agaaaatatg ctgggtgcgg    420

tggctcacgc ctgtaatccc agcactttgg aaggccaagg tgggcagatt gcccaagctc    480

aggagttcta aaccacatgg tgaaaccctg tttctactaa taatacaaaa aagagctggg    540

cgtgttggca cgcacctgta gtcccagcta                                     570


<210>  5673
<211>  98
<212>  PRT
<213>  Homosapiens

<400>  5673

Met Thr Gly Lys Asn Leu Pro Gly Arg Leu Leu Pro Thr Glu His Ser 
1               5                   10                  15      


Leu Phe Lys Lys Ala Leu Val Ser Lys Lys Arg Ser Val Ile Phe Tyr 
            20                  25                  30          


Tyr Leu Ala Thr Glu Ala Asn Gln Glu Leu Gly Cys Pro His Gln Pro 
        35                  40                  45              


Arg Lys Gly Asn Met Ser Ala Pro Phe Leu Pro Thr Leu Gln Gln His 
    50                  55                  60                  


Lys Asp Phe Leu Lys Glu Asn Met Leu Gly Ala Val Ala His Ala Cys 
65                  70                  75                  80  


Asn Pro Ser Thr Leu Glu Gly Gln Gly Gly Gln Ile Ala Gln Ala Gln 
                85                  90                  95      


Glu Phe 
        


<210>  5674
<211>  2387
<212>  DNA
<213>  Homosapiens

<400>  5674
caccattgtt ccatctgcga ggagcaccct ttctgcagaa agtaaaaatt gccttgctga     60

ggaaattaaa tatagcttaa ggattctgag ttgaagagca cagagctgca ggagaaagtg    120

actgagctgg agagtttgct ggaggagacc caggcaatct gcagagagaa ggagattcaa    180

ctggaaagcc tgaggcagag agaagcagaa ttctcctccg ctggacatag cctgcaagat    240

aaacagtctg tggaggagac cagtggagaa ggtccagaag tggaaatgga gtcctggcag    300

aagcgatacg attcgctcca aaagattgtg gagaagcagc agcagaagat ggatcagttg    360

cgctcacaag tacagagcct agagcaggaa gtggctcaag aagaaggaac aagccaggcc    420

ctgagagagg aggcccagcg aagggattca gccctgcagc agctgcgcac agccgtgaag    480

gagctttcag tgcaaaacca ggacttgatt gagaagaatc tgacactcca ggaacacctg    540

cgccaggccc aaccagggtc tccaccttca ccagacacgg cccagctggc acttgagctg    600

caccaggagt tggccagttg ccttcaagat ctgcaggctg tctgtagcat tgtgacccag    660

agggcccagg gccatgaccc caatctctcc ctgctcctgg gcattcactc agcacagcac    720

ccagagactc agctagattt gcagaagcca gatgtgatca agaggaaact agaagaggtt    780

caacagctgc gtcgtgacat tgaggactta aggaccacca tgtcagacag atatgcccag    840

gacatgggag aaaactgtgt cacacagtga ggaattctgg gggattcccc cagggaggag    900

ctgggctgct gagagcctag tccagcaggt ttctgccctg acattctctt gtctgctatt    960

cccagagagg tctcagaggg gaggggagag cctgcatctg ggggccaagg gctgattagg   1020

gaactgtgtc ctacccacac tggcatgttg gattacgttt gtcctgttaa ttcactctag   1080

acggtgagtt actaattaac ttttggcagg tacaacagat aagtcctcac aaactgttcc   1140

cagccctagg ctgacatgag agacgaacag gctgtccacc tttcttctcc atccaatggg   1200

atggatccat gttcattccc acttcacacc ttggtcctgc tgattagaga gctcatcaga   1260

ggggcctgga aaggctgagc aagtaccagt gacaatggcc atttaagaat tctcaggccc   1320

catgtgccag ccttcttggg aactgagctg gctttctggg ttttctcatg cctggtctta   1380

ctgcttcttc ctcagggctc ttgttctccc agaagcctca gggtaatgtg ttggttagca   1440

cgtaactact aggattgggg ccctagggat tatagccagg actctaatct gcctaccatg   1500

ccatttaaca agagatccca ctctccagct gccttgtgtc cctagggtcc tggccatgtg   1560

tttagtgtgc taaactttct cctttgttct caggccttcc aggtagtccc cttcctggac   1620

ttaagagtgc aaactcttct ctgtggttct agccttgggc agaattatat cccagagacc   1680

acagagcaac tgtcaagctg cttaccccct cacccagggc tacagcctgt gcccagccct   1740

ctaatttgtg cctctcttgt gttgggggtg gtgggggtta ttcctttccc tttcctgctc   1800

tggcctcctt gaaagttcag agtacccagt acaagtcagc tttaaagtac agcttttagt   1860

gtttcctggg ttgtttctct ggggctttag tgagggacct ttgccctctg gtttttcttg   1920

cctcctggtt tagggagcat ctcacacttg ttagtatctg gttgttgggc cagccgtgcc   1980

tcctctagat ctggagccag gccaggcagg ggccacgtgt gggccagtca gccactacaa   2040

gatttttgct aagctttggg ctgttggcag catcttggac ctcatgcctg ggcctgaatg   2100

aggctctttc ttaagtgttt ttacaagttt gtgttttatt tatggagtga cttatccctt   2160

ccattcagag cagccccacc cagccagccc ttcagcctct gggctcctgc tgcttaaagg   2220

cagagccgcc tggttggtct ccaccctgtg cattgggagc ccagccacca tgctgacggg   2280

tatttttcct cataaagttt ataaccagtt atttatatga atctttgtta tgtccatttg   2340

tttgtattgc gtattttgat tataaaataa agtatcttaa cagactc                 2387


<210>  5675
<211>  194
<212>  PRT
<213>  Homosapiens

<400>  5675

Met Glu Ser Trp Gln Lys Arg Tyr Asp Ser Leu Gln Lys Ile Val Glu 
1               5                   10                  15      


Lys Gln Gln Gln Lys Met Asp Gln Leu Arg Ser Gln Val Gln Ser Leu 
            20                  25                  30          


Glu Gln Glu Val Ala Gln Glu Glu Gly Thr Ser Gln Ala Leu Arg Glu 
        35                  40                  45              


Glu Ala Gln Arg Arg Asp Ser Ala Leu Gln Gln Leu Arg Thr Ala Val 
    50                  55                  60                  


Lys Glu Leu Ser Val Gln Asn Gln Asp Leu Ile Glu Lys Asn Leu Thr 
65                  70                  75                  80  


Leu Gln Glu His Leu Arg Gln Ala Gln Pro Gly Ser Pro Pro Ser Pro 
                85                  90                  95      


Asp Thr Ala Gln Leu Ala Leu Glu Leu His Gln Glu Leu Ala Ser Cys 
            100                 105                 110         


Leu Gln Asp Leu Gln Ala Val Cys Ser Ile Val Thr Gln Arg Ala Gln 
        115                 120                 125             


Gly His Asp Pro Asn Leu Ser Leu Leu Leu Gly Ile His Ser Ala Gln 
    130                 135                 140                 


His Pro Glu Thr Gln Leu Asp Leu Gln Lys Pro Asp Val Ile Lys Arg 
145                 150                 155                 160 


Lys Leu Glu Glu Val Gln Gln Leu Arg Arg Asp Ile Glu Asp Leu Arg 
                165                 170                 175     


Thr Thr Met Ser Asp Arg Tyr Ala Gln Asp Met Gly Glu Asn Cys Val 
            180                 185                 190         


Thr Gln 
        


<210>  5676
<211>  3095
<212>  DNA
<213>  Homosapiens

<400>  5676
accattgttc catctgcgag gagcaccctt tctgcagaaa gtaaaaattg ccttgctgag     60

gaaattaaat atagcttaag gattctgagt tgaagagcac agagctgcag gagaaagtga    120

ctgagctgga gagtttgctg gaggagaccc aggcaatctg cagagagaag gagattcaac    180

tggaaagcct gaggcagaga gaagcagaat tctcctccgc tggacatagc ctgcaagata    240

aacagtctgt ggaggagacc agtggagaag gtccagaagt ggaaatggag tcctggcaga    300

agcgatacga ttcgctccaa aagattgtgg agaagcagca gcagaagatg gatcagttgc    360

gctcacaagt acagagccta gagcaggaag tggctcaaga agaaggaaca agccaggccc    420

tgagagagga ggcccagcga agggattcag ccctgcagca gctgcgcaca gccgtgaagg    480

agctttcagt gcaaaaccag gacttgattg agaagaatct gacactccag gaacacctgc    540

gccaggccca accagggtct ccaccttcac cagacacggc ccagctggca cttgagctgc    600

accaggagtt ggccagttgc cttcaagatc tgcaggctgt ctgtagcatt gtgacccaga    660

gggcccaggg ccatgacccc aatctctccc tgctcctggg cattcactca gcacagcacc    720

cagagactca gctagatttg cagaagccag atgtgatcaa gaggaaacta gaagaggttc    780

aacagctgcg tcgtgacatt gaggacttaa ggaccaccat gtcagacaga tatgcccagg    840

acatgggaga aaactgtgtc acacagtgag gaattctggg ggattccccc agggaggagc    900

tgggctgctg agagcctagt ccagcaggtt tctgccctga cattctcttg tctgctattc    960

ccagagaggt ctcagagggg aggggagagc ctgcatctgg gggccaaggg ctgattaggg   1020

aactgtgtcc tacccacact ggcatgttgg attacgtttg tcctgttaat tcactctaga   1080

cggtgagtta ctaattaact tttggcaggt acaacagata agtcctcaca aactgttccc   1140

agccctaggc tgacatgaga gacgaacagg ctgtccacct ttcttctcca tccaatggga   1200

tggatccatg ttcattccca cttcacacct tggtcctgct gattagagag ctcatcagag   1260

gggcctggaa aggctgagca agtaccagtg acaatggcca tttaagaatt ctcaggcccc   1320

atgtgccagc cttcttggga actgagctgg ctttctgggt tttctcatgc ctggtcttac   1380

tgcttcttcc tcagggctct tgttctccca gaagcctcag ggtaatgtgt tggttagcac   1440

gtaactacta ggattggggc cctagggatt atagccagga ctctaatctg cctaccatgc   1500

catttaacaa gagatcccac tctccagctg ccttgtgtcc ctagggtcct ggccatgtgt   1560

ttagtgtgct aaactttctc ctttgttctc aggccttcca ggtagtcccc ttcctggact   1620

taagagtgca aactcttctc tgtggttcta gccttgggca gaattatatc ccagagacca   1680

cagagcaact gtcaagctgc ttaccccctc acccagggct acagcctgtg cccagccctc   1740

taatttgtgc ctctcttgtg ttgggggtgg tgggggttat tcctttccct ttcctgctct   1800

ggcctccttg aaagttcaga gtacccagta caagtcagct ttaaagtaca gcttttagtg   1860

tttcctgggt tgtttctctg gggctttagt gagggacctt tgccctctgg tttttcttgc   1920

ctcctggttt agggagcatc tcacacttgt tagtatctgg ttgttgggcc agccgtgcct   1980

cctctagatc tggagccagg ccaggcaggg gccacgtgtg ggccagtcag ccactacaag   2040

atttttgcta agctttgggc tgttggcagc atcttggacc tcatgcctgg gcctgaatga   2100

ggctctttct taagtgtttt tacaagtttg tgttttattt atggagtgac ttatcccttc   2160

cattcagagc agccccaccc agccagccct tcagcctctg ggctcctgct gcttaaaggc   2220

agagccgcct ggttggtctc caccctgtgc attgggagcc cagccaccat gctgacgggt   2280

atttttcctc ataaagttta taaccagtta tttatatgaa tctttgttat gtccatttgt   2340

ttgtattgcg tattttgatt ataaaataaa gtatcttaac agactcctca gttttccata   2400

cccttccatc accaccacca cgctattcta cccctcactt tggcttgtta gagccaaaca   2460

cctgggtgtt cagccaggtc ccccaggcag cagcgtggag gaacctttgg caggtccagc   2520

cagcctcatg tccctatcta tctctgccac ctctgctcct ctgtcgttct atagaaccag   2580

atctcttccc actcactttc tcttgggcaa accttccctg agtcataaca gaagtttgtc   2640

actggaaagt ttcagcagtc ctctcaggaa gttggcagcc tctgggttgc tgtgaggaag   2700

tggctttacc agagcaaggg ttgtctttct gggctgttaa cctgcctgag ccctggacca   2760

gggggacatc tgagaagcat gatgttgagt gccagacagc taggtctcca aagttgggct   2820

cgttgctgga gtctgccccc tcaaccgctg aattcttgct gggagtagta gcagtttggg   2880

aatgccatct gcagcatgga gctggggttg agcttggacc accccaagac ctggggtgga   2940

tcttaagggt cagcttgagc ctaggctctc gagtcctgac atcatcctct accgccacgc   3000

tttccagctg tcagccttgg tctccatctg gttccttgag ggtgtggcct ctgcgtcctg   3060

ctatcaccct tccttgtcta aaccttccca cctga                              3095


<210>  5677
<211>  194
<212>  PRT
<213>  Homosapiens

<400>  5677

Met Glu Ser Trp Gln Lys Arg Tyr Asp Ser Leu Gln Lys Ile Val Glu 
1               5                   10                  15      


Lys Gln Gln Gln Lys Met Asp Gln Leu Arg Ser Gln Val Gln Ser Leu 
            20                  25                  30          


Glu Gln Glu Val Ala Gln Glu Glu Gly Thr Ser Gln Ala Leu Arg Glu 
        35                  40                  45              


Glu Ala Gln Arg Arg Asp Ser Ala Leu Gln Gln Leu Arg Thr Ala Val 
    50                  55                  60                  


Lys Glu Leu Ser Val Gln Asn Gln Asp Leu Ile Glu Lys Asn Leu Thr 
65                  70                  75                  80  


Leu Gln Glu His Leu Arg Gln Ala Gln Pro Gly Ser Pro Pro Ser Pro 
                85                  90                  95      


Asp Thr Ala Gln Leu Ala Leu Glu Leu His Gln Glu Leu Ala Ser Cys 
            100                 105                 110         


Leu Gln Asp Leu Gln Ala Val Cys Ser Ile Val Thr Gln Arg Ala Gln 
        115                 120                 125             


Gly His Asp Pro Asn Leu Ser Leu Leu Leu Gly Ile His Ser Ala Gln 
    130                 135                 140                 


His Pro Glu Thr Gln Leu Asp Leu Gln Lys Pro Asp Val Ile Lys Arg 
145                 150                 155                 160 


Lys Leu Glu Glu Val Gln Gln Leu Arg Arg Asp Ile Glu Asp Leu Arg 
                165                 170                 175     


Thr Thr Met Ser Asp Arg Tyr Ala Gln Asp Met Gly Glu Asn Cys Val 
            180                 185                 190         


Thr Gln 
        


<210>  5678
<211>  568
<212>  DNA
<213>  Homosapiens

<400>  5678
tttctgcaga aagtaaaaat tgccttgctg aggaaattaa atatagctta aggattctga     60

gttgaagagc acagagctgc aggagaaagt gactgagctg gagagtttgc tggaggagac    120

ccaggcaatc tgcagagaga aggagattca actggaaagc ctgaggcaga gagaagcaga    180

attctcctcc gctggacata gcctgcaaga taaacagtct gtggaggaga ccagtggaga    240

aggtccagaa gtggaaatgg agtcctggca gaagcgatac gattcgctcc aaaagattgt    300

ggagaagcag cagcagaaga tggatcagtt gcgctcacaa gtacagagtc tcgctcttgt    360

cgcccaggct ggagtgcaat ggcgcaatct cggctcactg taacctctgc ctcccaggtt    420

caagcaattc tcctgcctca gcctcccgag tagctggtat tacgggtgcc caccatcacg    480

cccggctaat ttttgtattt tttgtagaga cggggtttca ccacgttggc cagactggtc    540

tcgaactcct gacctcaggt gatctgcc                                       568


<210>  5679
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  5679

Met Glu Ser Trp Gln Lys Arg Tyr Asp Ser Leu Gln Lys Ile Val Glu 
1               5                   10                  15      


Lys Gln Gln Gln Lys Met Asp Gln Leu Arg Ser Gln Val Gln Ser Leu 
            20                  25                  30          


Ala Leu Val Ala Gln Ala Gly Val Gln Trp Arg Asn Leu Gly Ser Leu 
        35                  40                  45              


<210>  5680
<211>  443
<212>  DNA
<213>  Homosapiens

<400>  5680
gaggagacca gtggagaagg tccagaagtg gaaatggagt cctggcagaa gcgatacgat     60

tcgctccaaa agattgtgga gaagcagcag cagaagatgg atcagttgcg ctcacaagta    120

caggtgagca ggaatccttg ggacatggtg ggcagaactt aatgatggaa tctctagaat    180

ttagccaata tttattttgt tctctgccat gcaggttgct cagtgttagg gatacaaaaa    240

gaatgagacc cagtcagtgc ttttgagcct tgctgagagg acacaaatat agtagggagt    300

ttcagcacag tactgtgaga gcagtcccca cagtatcctg ggggagtgca ggagagtcag    360

tgggaggaag ggaggtaaaa gagaggtttc tggagatcct gaacctacaa ggatgaggag    420

ttagccaggc aaacaagagg agc                                            443


<210>  5681
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  5681

Met Glu Ser Trp Gln Lys Arg Tyr Asp Ser Leu Gln Lys Ile Val Glu 
1               5                   10                  15      


Lys Gln Gln Gln Lys Met Asp Gln Leu Arg Ser Gln Val Gln Val Ser 
            20                  25                  30          


Arg Asn Pro Trp Asp Met Val Gly Arg Thr 
        35                  40          


<210>  5682
<211>  1769
<212>  DNA
<213>  Homosapiens

<400>  5682
agctttcagt gcaaaaccag gacttgattg agaagaatct gacactccag gaacacctgc     60

gccaggccca accagggtct ccactcccca gcagcacagc acccagagac tcagctagat    120

ttgcagaagc cagatgtgat caagaggaaa ctagaagagg ttcaacagct gcgtcgtgac    180

attgaggact taaggaccac catgtcagac agatatgccc aggacatggg agaaaactgt    240

gtcacacagt gaggaattct gggggattcc cccagggagg agctgggctg ctgagagcct    300

agtccagcag gtttctgccc tgacattctc ttgtctgcta ttcccagaga ggtctcagag    360

gggaggggag agcctgcatc tgggggccaa gggctgatta gggaactgtg tcctacccac    420

actggcatgt tggattacgt ttgtcctgtt aattcactct agacggtgag ttactaatta    480

acttttggca ggtacaacag ataagtcctc acaaactgtt cccagcccta ggctgacatg    540

agagacgaac aggctgtcca cctttcttct ccatccaatg ggatggatcc atgttcattc    600

ccacttcaca ccttggtcct gctgattaga gagctcatca gaggggcctg gaaaggctga    660

gcaagtacca gtgacaatgg ccatttaaga attctcaggc cccatgtgcc agccttcttg    720

ggaactgagc tggctttctg ggttttctca tgcctggtct tactgcttct tcctcagggc    780

tcttgttctc ccagaagcct cagggtaatg tgttggttag cacgtaacta ctaggattgg    840

ggccctaggg attatagcca ggactctaat ctgcctacca tgccatttaa caagagatcc    900

cactctccag ctgccttgtg tccctagggt cctggccatg tgtttagtgt gctaaacttt    960

ctcctttgtt ctcaggcctt ccaggtagtc cccttcctgg acttaagagt gcaaactctt   1020

ctctgtggtt ctagccttgg gcagaattat atcccagaga ccacagagca actgtcaagc   1080

tgcttacccc ctcacccagg gctacagcct gtgcccagcc ctctaatttg tgcctctctt   1140

gtgttggggg tggtgggggt tattcctttc cctttcctgc tctggcctcc ttgaaagttc   1200

agagtaccca gtacaagtca gctttaaagt acagctttta gtgtttcctg ggttgtttct   1260

ctggggcttt agtgagggac ctttgccctc tggtttttct tgcctcctgg tttagggagc   1320

atctcacact tgttagtatc tggttgttgg gccagccgtg cctcctctag atctggagcc   1380

aggccaggca ggggccacgt gtgggccagt cagccactac aagatttttg ctaagctttg   1440

ggctgttggc agcatcttgg acctcatgcc tgggcctgaa tgaggctctt tcttaagtgt   1500

ttttacaagt ttgtgtttta tttatggagt gacttatccc ttccattcag agcagcccca   1560

cccagccagc ccttcagcct ctgggctcct gctgcttaaa ggcagagccg cctggttggt   1620

ctccaccctg tgcattggga gcccagccac catgctgacg ggtatttttc ctcataaagt   1680

ttataaccag ttatttatat gaatctttgt tatgtccatt tgtttgtatt gcgtattttg   1740

attataaaat aaagtatctt aacagactc                                     1769


<210>  5683
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  5683

Met Pro Arg Thr Trp Glu Lys Thr Val Ser His Ser Glu Glu Phe Trp 
1               5                   10                  15      


Gly Ile Pro Pro Gly Arg Ser Trp Ala Ala Glu Ser Leu Val Gln Gln 
            20                  25                  30          


Val Ser Ala Leu Thr Phe Ser Cys Leu Leu Phe Pro Glu Arg Ser Gln 
        35                  40                  45              


Arg Gly Gly Glu Ser Leu His Leu Gly Ala Lys Gly 
    50                  55                  60  


<210>  5684
<211>  2478
<212>  DNA
<213>  Homosapiens

<400>  5684
agctttcagt gcaaaaccag gacttgattg agaagaatct gacactccag gaacacctgc     60

gccaggccca accagggtct ccactcccca gcagcacagc acccagagac tcagctagat    120

ttgcagaagc cagatgtgat caagaggaaa ctagaagagg ttcaacagct gcgtcgtgac    180

attgaggact taaggaccac catgtcagac agatatgccc aggacatggg agaaaactgt    240

gtcacacagt gaggaattct gggggattcc cccagggagg agctgggctg ctgagagcct    300

agtccagcag gtttctgccc tgacattctc ttgtctgcta ttcccagaga ggtctcagag    360

gggaggggag agcctgcatc tgggggccaa gggctgatta gggaactgtg tcctacccac    420

actggcatgt tggattacgt ttgtcctgtt aattcactct agacggtgag ttactaatta    480

acttttggca ggtacaacag ataagtcctc acaaactgtt cccagcccta ggctgacatg    540

agagacgaac aggctgtcca cctttcttct ccatccaatg ggatggatcc atgttcattc    600

ccacttcaca ccttggtcct gctgattaga gagctcatca gaggggcctg gaaaggctga    660

gcaagtacca gtgacaatgg ccatttaaga attctcaggc cccatgtgcc agccttcttg    720

ggaactgagc tggctttctg ggttttctca tgcctggtct tactgcttct tcctcagggc    780

tcttgttctc ccagaagcct cagggtaatg tgttggttag cacgtaacta ctaggattgg    840

ggccctaggg attatagcca ggactctaat ctgcctacca tgccatttaa caagagatcc    900

cactctccag ctgccttgtg tccctagggt cctggccatg tgtttagtgt gctaaacttt    960

ctcctttgtt ctcaggcctt ccaggtagtc cccttcctgg acttaagagt gcaaactctt   1020

ctctgtggtt ctagccttgg gcagaattat atcccagaga ccacagagca actgtcaagc   1080

tgcttacccc ctcacccagg gctacagcct gtgcccagcc ctctaatttg tgcctctctt   1140

gtgttggggg tggtgggggt tattcctttc cctttcctgc tctggcctcc ttgaaagttc   1200

agagtaccca gtacaagtca gctttaaagt acagctttta gtgtttcctg ggttgtttct   1260

ctggggcttt agtgagggac ctttgccctc tggtttttct tgcctcctgg tttagggagc   1320

atctcacact tgttagtatc tggttgttgg gccagccgtg cctcctctag atctggagcc   1380

aggccaggca ggggccacgt gtgggccagt cagccactac aagatttttg ctaagctttg   1440

ggctgttggc agcatcttgg acctcatgcc tgggcctgaa tgaggctctt tcttaagtgt   1500

ttttacaagt ttgtgtttta tttatggagt gacttatccc ttccattcag agcagcccca   1560

cccagccagc ccttcagcct ctgggctcct gctgcttaaa ggcagagccg cctggttggt   1620

ctccaccctg tgcattggga gcccagccac catgctgacg ggtatttttc ctcataaagt   1680

ttataaccag ttatttatat gaatctttgt tatgtccatt tgtttgtatt gcgtattttg   1740

attataaaat aaagtatctt aacagactcc tcagttttcc atacccttcc atcaccacca   1800

ccacgctatt ctacccctca ctttggcttg ttagagccaa acacctgggt gttcagccag   1860

gtcccccagg cagcagcgtg gaggaacctt tggcaggtcc agccagcctc atgtccctat   1920

ctatctctgc cacctctgct cctctgtcgt tctatagaac cagatctctt cccactcact   1980

ttctcttggg caaaccttcc ctgagtcata acagaagttt gtcactggaa agtttcagca   2040

gtcctctcag gaagttggca gcctctgggt tgctgtgagg aagtggcttt accagagcaa   2100

gggttgtctt tctgggctgt taacctgcct gagccctgga ccagggggac atctgagaag   2160

catgatgttg agtgccagac agctaggtct ccaaagttgg gctcgttgct ggagtctgcc   2220

ccctcaaccg ctgaattctt gctgggagta gtagcagttt gggaatgcca tctgcagcat   2280

ggagctgggg ttgagcttgg accaccccaa gacctggggt ggatcttaag ggtcagcttg   2340

agcctaggct ctcgagtcct gacatcatcc tctaccgcca cgctttccag ctgtcagcct   2400

tggtctccat ctggttcctt gagggtgtgg cctctgcgtc ctgctatcac ccttccttgt   2460

ctaaaccttc ccacctga                                                 2478


<210>  5685
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  5685

Met Pro Arg Thr Trp Glu Lys Thr Val Ser His Ser Glu Glu Phe Trp 
1               5                   10                  15      


Gly Ile Pro Pro Gly Arg Ser Trp Ala Ala Glu Ser Leu Val Gln Gln 
            20                  25                  30          


Val Ser Ala Leu Thr Phe Ser Cys Leu Leu Phe Pro Glu Arg Ser Gln 
        35                  40                  45              


Arg Gly Gly Glu Ser Leu His Leu Gly Ala Lys Gly 
    50                  55                  60  


<210>  5686
<211>  603
<212>  DNA
<213>  Homosapiens

<400>  5686
cacaaactgt tcccagccct aggctgacat gagagacgaa caggctgtcc acctttcttc     60

tccatccaat gggatggatc catgttcatt cccacttcac accttggtcc tgctgattag    120

agagctcatc agaggggcct ggaaaggctg agcaagtacc agtgacaatg gccatttaag    180

aattctcagg ccccatgtgc cagccttctt gggaactgag ctggctttct gggttttctc    240

atgcctggtc ttactgcttc ttcctcaggg ctcttgttct cccagaagcc tcagggtaat    300

gtgttggtta gcacgtaact actagggtcc tggccatgtg tttagtgtgc taaactttct    360

cctttgttct caggccttcc aggtagtccc cttcctggac ttaagagtgc aaactcttct    420

ctgtggttct agccttgggc agaattatat cccagagacc acagagcaac tgtcaagctg    480

cttaccccct cacccagggc tacagcctgt gcccagccct ctaatttgtg cctctcttgt    540

gttgggggtg gtgggggtta ttcctttccc tttcctgctc tggcctcctt gaaagttcag    600

agt                                                                  603


<210>  5687
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5687

Met Arg Asp Glu Gln Ala Val His Leu Ser Ser Pro Ser Asn Gly Met 
1               5                   10                  15      


Asp Pro Cys Ser Phe Pro Leu His Thr Leu Val Leu Leu Ile Arg Glu 
            20                  25                  30          


Leu Ile Arg Gly Ala Trp Lys Gly 
        35                  40  


<210>  5688
<211>  2139
<212>  DNA
<213>  Homosapiens

<400>  5688
cgggtatttt tcctcataaa gtttataacc agttatttat atgaatcttt gttatgtcca     60

tttgtttgta ttgcgtattt tgattataaa ataaagtatc ttaacagact cctcagtttt    120

ccataccctt ccatcaccac caccacgcta ttctacccct cactttggct tgttagagcc    180

aaacacctgg gtgttcagcc aggtccccca ggcagcagcg tggaggaacc tttggcaggt    240

ccagccagcc tcatgtccct atctatctct gccacctctg ctcctctgtc gttctataga    300

accagatctc ttcccactca ctttctcttg ggcaaacctt ccctgagtca taacagaagt    360

ttgtcactgg aaagtttcag cagtcctctc aggaagttgg cagcctctgg gttgctgtga    420

ggaagtggct ttaccagagc aagggttgtc tttctgggct gttaacctgc ctgagccctg    480

gaccaggggg acatctgaga agcatgatgt tgagtgccag acagctaggt ctccaaagtt    540

gggctcgttg ctggagtctg ccccctcaac cgctgaattc ttgctgggag tagtagcagt    600

ttgggaatgc catctgcagc atggagctgg ggttgagctt ggaccacccc aagacctggg    660

gtggatctta agggtcagct tgagcctagg ctctcgagtc ctgacatcat cctctaccgc    720

cacgctttcc agctgtcagc cttggtctcc atctggttcc ttgagggtgt ggcctctgcg    780

tcctgctatc acccttcctt gtctaaacct tcccacctga gtggagagga acttggggga    840

aaatctctaa gcatgggctc ttcctgctgt cctatgcttc ctatccccta gggttagtgg    900

tgcgtgttgg gtggtggagc gagggatccc ttggagcaag gttcttagag aactttgggt    960

ctgaaagcag ctcaaacctt ccaaagcccc aagcttccct gtgctattag agcacctcct   1020

cctggagaga gcggctctcg tggctgggga gttggatgca ccaaacctgt gtgcggctgg   1080

agagggaggc ttctgccaga ccctctcccg ggcctgtcct gccacccagg cccctcccca   1140

gtctcacact gagctccaga tcagggaagg gccgaaaagg acgatcaggg cagccgcaga   1200

aggggcgccc tgcgtgggac gggtccgttg cgcgcctggt aaccgagggg gaagggaagg   1260

ggcctctggc gtgcggggcg gtgtcgcgca ggtcccaccc cgcctgcccg cgccgcccat   1320

tggtcccgag cgcgatgact tggcgggcgg agcaggaagg aaaccgctcc cgagcacggc   1380

ggcggcgtcg tctcccggca gtgcagctgc cgctaccgcc gccctctgcc cgccggcccg   1440

tctgtctacc cccagcatga gcggcctgcg cgtctacagc acgtcggtca ccggctcccg   1500

cgaaatcaag tcccagcaga gcgaggtgac ccgaatcctg gatgggaagc gcatccaata   1560

ccagctagtg gacatctccc aggacaacgc cctgagggat gagatgcgag ccttggcagg   1620

caaccccaag gccaccccac cccagattgt caacggggac cagtactgtg gggactatga   1680

gctcttcgtg gaggctgtgg aacaaaacac gctgcaggag ttcctgaagc tggcttgagt   1740

caagcctgtc cagagttccc ctgctggact ccatcaccac actcccccca gccttcacct   1800

ggccatgaag gaccttttga ccaactccct gtcattccta acctaacctt agagtccctc   1860

ccccaatgca ggccacttct cctccctcct ctctaaatgt agtcccctct cctccatcta   1920

aaggcaacat tccttaccca ttagtctcag aaattgtctt aagcaacagc cccaaatgct   1980

ggctgccccc agccaagcat tggggccgcc atcctgcctg gcactggctg atgggcacct   2040

ctgttggttc catcagccag agctctgcca aaggccccgc agtccctctc ccaggaggac   2100

cctagaggca attaaatgat gtcctgttcc attggcact                          2139


<210>  5689
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  5689

Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val Thr Gly Ser Arg Glu 
1               5                   10                  15      


Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile Leu Asp Gly Lys Arg 
            20                  25                  30          


Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn Ala Leu Arg Asp 
        35                  40                  45              


Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala Thr Pro Pro Gln Ile 
    50                  55                  60                  


Val Asn Gly Asp Gln Tyr Cys Gly Asp Tyr Glu Leu Phe Val Glu Ala 
65                  70                  75                  80  


Val Glu Gln Asn Thr Leu Gln Glu Phe Leu Lys Leu Ala 
                85                  90              


<210>  5690
<211>  874
<212>  DNA
<213>  Homosapiens

<400>  5690
tctcccggca gtgcagctgc cgctaccgcc gccctctgcc cgccggcccg tctgtctacc     60

cccagcatga gcggcctgcg cgtctacagc acgtcggtca ccggctcccg cgaaatcaag    120

tcccagcaga gcgaggtgac ccgaatcctg gatgggaagc gcatccaata ccagctagtg    180

gacatctccc aggacaacgc cctgagggat gagatgcgag ccttggcagg caaccccaag    240

gccaccccac cccagattgt caacggggac cagtactgtg gggtatgggc tgggggacgg    300

gggggtgggg ggagtgttgg aagaggactc tagccagggt catatctgcc acaaagcact    360

tgggccccct gcattcaggt gaccacccct cgcctcccct tctccaggac tatgagctct    420

tcgtggaggc tgtggaacaa aacacgctgc aggagttcct gaagctggct tgagtcaagc    480

ctgtccagag ttcccctgct ggactccatc accacactcc ccccagcctt cacctggcca    540

tgaaggacct tttgaccaac tccctgtcat tcctaaccta accttagagt ccctccccca    600

atgcaggcca cttctcctcc ctcctctcta aatgtagtcc cctctcctcc atctaaaggc    660

aacattcctt acccattagt ctcagaaatt gtcttaagca acagccccaa atgctggctg    720

cccccagcca agcattgggg ccgccatcct gcctggcact ggctgatggg cacctctgtt    780

ggttccatca gccagagctc tgccaaaggc cccgcagtcc ctctcccagg aggaccctag    840

aggcaattaa atgatgtcct gttccattgg cact                                874


<210>  5691
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  5691

Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val Thr Gly Ser Arg Glu 
1               5                   10                  15      


Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile Leu Asp Gly Lys Arg 
            20                  25                  30          


Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn Ala Leu Arg Asp 
        35                  40                  45              


Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala Thr Pro Pro Gln Ile 
    50                  55                  60                  


Val Asn Gly Asp Gln Tyr Cys Gly Val Trp Ala Gly Gly Arg Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Val Gly Arg Gly Leu 
                85              


<210>  5692
<211>  2525
<212>  DNA
<213>  Homosapiens

<400>  5692
gacaacaaga tggcggcgct gcgggacggc tagcggccct gcgtgggagt tcctgacagc     60

tggattctag aagtagaact atgagctcac ctttggcctc ccttagcaag acccgaaaag    120

tgcccctgcc ctcggagcct atgaatcctg ggaggcgagg aatccgcatc tatggagatg    180

aagatgaggt ggacatgttg agtgatgggt gtggctcaga agaaaagatc tcagtccctt    240

cctgctatgg cggcataggt gcccctgtga gtcggcaagg ggactcattg gcgccccctg    300

aggtggactt tgacaggctg ctggccagcc tgcaggatct tagtgagctg gtggtagagg    360

gtgacaccca agtgacacca gtgcccggcg gggcacggct gcgtaccctc gagcccatcc    420

cgctgaagct ctaccggaat ggcatcatga tgttcgacgg gcccttccag cccttctacg    480

atccctccac acagcgctgc ctccgagaca tattggatgg cttctttccc tcagagctcc    540

agcgactgta ccccaatggg gtccccttta aggtgagtga cttgcgcaat caggtctacc    600

tggaggatgg actggacccc ttcccaggcg agggccgtgt ggtgggcagg cagctgatgc    660

acaaggcctt ggacagggtg gaggagcacc caggctccag gatgactgct gagaaatttc    720

tgaacaggct ccccaagttt gtgatccggc aaggcgaggt gattgacatc cggggcccca    780

tcagggacac cttgcagaac tgctgcccat tgcctgcccg gatccaggag attgtggtgg    840

agacgcccac cttggccgct gagcgagaga ggagccagga gtcacccaac acgccggcac    900

ccccgctctc catgctgcgc atcaagtctg agaatgggga acaggccttc ctactgatga    960

tgcagcctga caacaccatt ggggacgtgc gagctctgct agcgcaggcc agggtcatgg   1020

atgcctctgc ctttgagatc ttcagcacat tcccgcccac cctctaccag gacgatacac   1080

tcacgctgca ggctgcaggc cttgtgccca aagcagcact gctgctgcgg gcacgccgag   1140

ccccgaagtc cagcctgaaa ttcagtcctg gtccctgtcc cggtcccggt cccggcccca   1200

gtcccggtcc cggtcccggc cccagtcccg gtcccggtcc cggccccagt ccctgtcctg   1260

gacccagtcc cagcccccaa taaagcaccc gccccctcaa cccgctgctc cgccaggctc   1320

ttgggtgggc catctcgcca ggcacgtagg aaaggcctgg gaccagctgg gccagggagg   1380

gggcggtgcc gacccgcccc ttggtaactc gagccccggc tggcgggcct ggctgctggg   1440

tctttgtctt ctaggttcct ctttctccca agaagggcta agtggatcct gtgaagggag   1500

ggatgcagtg gggggaagga gctggcccca gctgggttta cattctcagc tgggacagca   1560

gagcctcact gtgtatgtgt gcagccagca gatacctgtg cacaggcaca gacccaccaa   1620

ctcgtgggga cacttcaaca ccgcacaaag ccattttgcc actagaccca tgcccccaaa   1680

ttagcagaac tgcagctggg tacccacctc ccatgataca ctcattctta gccattgtgc   1740

tccaacacag gcgcatggga tggccacact cactgacagg catggagatg tgcactacac   1800

accaaggcac aagcatgata tggacacatg catgtgaact ggagggtggc ccacccagac   1860

atctccagaa accactggtc catacaggta tttgtgtgtc agacatatcc aaacacatgc   1920

actaacaaac acagaggtga cagtcacaag agaacagctc agccaccctt cccacagagc   1980

agtctcagca cagtcacaac taccaacctt gcccagggca gggacccagg aggcccaggc   2040

cacaaccaac cagacacagt gccaatggaa caggacatca tttaattgcc tctagggtcc   2100

tcctgggaga gggactgcgg ggcctttggc agagctctgg ctgatggaac caacagaggt   2160

gcccatcagc cagtgccagg caggatggcg gccccaatgc ttggctgggg gcagccagca   2220

tttggggctg ttgcttaaga caatttctga gactaatggg taaggaatgt tgcctttaga   2280

tggaggagag gggactacat ttagagagga gggaggagaa gtggcctgca ttgggggagg   2340

gactctaagg ttaggttagg aatgacaggg agttggtcaa aaggtccttc atggccaggt   2400

gaaggctggg gggagtgtgg tgatggagtc cagcagggga actctggaca ggcttgactc   2460

aagccagctt caggaactcc tgcagcgtgt tttgttccac agcctccacg aagagctcat   2520

agtcc                                                               2525


<210>  5693
<211>  400
<212>  PRT
<213>  Homosapiens

<400>  5693

Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Glu Asp Glu Val Asp Met Leu Ser Asp Gly Cys Gly Ser Glu Glu 
        35                  40                  45              


Lys Ile Ser Val Pro Ser Cys Tyr Gly Gly Ile Gly Ala Pro Val Ser 
    50                  55                  60                  


Arg Gln Gly Asp Ser Leu Ala Pro Pro Glu Val Asp Phe Asp Arg Leu 
65                  70                  75                  80  


Leu Ala Ser Leu Gln Asp Leu Ser Glu Leu Val Val Glu Gly Asp Thr 
                85                  90                  95      


Gln Val Thr Pro Val Pro Gly Gly Ala Arg Leu Arg Thr Leu Glu Pro 
            100                 105                 110         


Ile Pro Leu Lys Leu Tyr Arg Asn Gly Ile Met Met Phe Asp Gly Pro 
        115                 120                 125             


Phe Gln Pro Phe Tyr Asp Pro Ser Thr Gln Arg Cys Leu Arg Asp Ile 
    130                 135                 140                 


Leu Asp Gly Phe Phe Pro Ser Glu Leu Gln Arg Leu Tyr Pro Asn Gly 
145                 150                 155                 160 


Val Pro Phe Lys Val Ser Asp Leu Arg Asn Gln Val Tyr Leu Glu Asp 
                165                 170                 175     


Gly Leu Asp Pro Phe Pro Gly Glu Gly Arg Val Val Gly Arg Gln Leu 
            180                 185                 190         


Met His Lys Ala Leu Asp Arg Val Glu Glu His Pro Gly Ser Arg Met 
        195                 200                 205             


Thr Ala Glu Lys Phe Leu Asn Arg Leu Pro Lys Phe Val Ile Arg Gln 
    210                 215                 220                 


Gly Glu Val Ile Asp Ile Arg Gly Pro Ile Arg Asp Thr Leu Gln Asn 
225                 230                 235                 240 


Cys Cys Pro Leu Pro Ala Arg Ile Gln Glu Ile Val Val Glu Thr Pro 
                245                 250                 255     


Thr Leu Ala Ala Glu Arg Glu Arg Ser Gln Glu Ser Pro Asn Thr Pro 
            260                 265                 270         


Ala Pro Pro Leu Ser Met Leu Arg Ile Lys Ser Glu Asn Gly Glu Gln 
        275                 280                 285             


Ala Phe Leu Leu Met Met Gln Pro Asp Asn Thr Ile Gly Asp Val Arg 
    290                 295                 300                 


Ala Leu Leu Ala Gln Ala Arg Val Met Asp Ala Ser Ala Phe Glu Ile 
305                 310                 315                 320 


Phe Ser Thr Phe Pro Pro Thr Leu Tyr Gln Asp Asp Thr Leu Thr Leu 
                325                 330                 335     


Gln Ala Ala Gly Leu Val Pro Lys Ala Ala Leu Leu Leu Arg Ala Arg 
            340                 345                 350         


Arg Ala Pro Lys Ser Ser Leu Lys Phe Ser Pro Gly Pro Cys Pro Gly 
        355                 360                 365             


Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly 
    370                 375                 380                 


Pro Gly Pro Gly Pro Ser Pro Cys Pro Gly Pro Ser Pro Ser Pro Gln 
385                 390                 395                 400 


<210>  5694
<211>  2642
<212>  DNA
<213>  Homosapiens

<400>  5694
gacaacaaga tggcggcgct gcgggacggc tagcggccct gcgtgggagt tcctgacagc     60

tggattctag aagtagaact atgagctcac ctttggcctc ccttagcaag acccgaaaag    120

tgcccctgcc ctcggagcct atgaatcctg ggaggcgagg aatccgcatc tatggagatg    180

aagatgaggt ggacatgttg agtgatgggt gtggctcaga agaaaagatc tcagtccctt    240

cctgctatgg cggcataggt gcccctgtga gtcggcaagt ccctgcatcc catgactcgg    300

agctgatggc cttcatgacg aggaagttgt gggacctgga gcagcaggtg aaggcccaga    360

ctgatgagat actgtccaag gatcagaaga tagcggccct agaggacctg gtgcagaccc    420

tccggccaca cccagccgag gcaaccctgc agcggcagga ggaactggag acgatgtgtg    480

tgcagctgca gcggcaggtc agggagatgg agcggttcct cagtgactat ggcctgcagt    540

gggtgggcga gcccatggac caggaggact cagagagcaa gacagtctca gagcatggcg    600

agagggactg gatgacagcc aagaagttct ggaagccagg ggactcattg gcgccccctg    660

aggtggactt tgacaggctg ctggccagcc tgcaggatct tagtgagctg gtggtagagg    720

gtgacaccca agtgacacca gtgcccggcg gggcacggct gcgtaccctc gagcccatcc    780

cgctgaagct ctaccggaat ggcatcatga tgttcgacgg gcccttccag cccttctacg    840

atccctccac acagcgctgc ctccgagaca tattggatgg cttctttccc tcagagctcc    900

agcgactgta ccccaatggg gtccccttta aggtgataag ctgctcctca aaccacacct    960

ttggggattt tgaagggagt ggggatacac agcctcccca gacacctccc attctgaggg   1020

gaagccgctg cactccctgg gggaccccag tctgatgccc tccaggagga taagtctgaa   1080

gccgggctgg gaagggagcg gagaggcccg aaacagagca gcaggcagcg ccctctgctg   1140

gcaccctgga gacagcctcg gctgcggggc ccctgccttc tagtcctccc cagctttcag   1200

gacaccttga caacctgggg tccctgcaga agtggcccgg ctgtccccca agtctcctga   1260

agctatctgg gtagggtggg aggcagtgct gtgagccaca aatgcaaagc agaggggaca   1320

gatgttggga ctcaaagaca tgaggtagag ctggccccat gggtaggtgc caccaccaga   1380

gcccatgagg cttcgtgttc tagaaggtgg tgggttagtg ccgcactgag ggcgtgtccg   1440

ggagggagca tgtgtcacca gggctcagga aacagcatga gtcatgacgc gggggtgttt   1500

aaggcattcg tgccacagcg gggacctcgg agctatgcct tgataaggca agtgaggtta   1560

catgtacgat gatgcggttt gtgctgcaga ctggaaaaaa gcaggggctt tgtcctctcc   1620

tgaccccctc acactctgcc ttcacggtag gctcctgaga ggggggtctc caaggagggt   1680

gtcagtactg cagcttcagc tggcgtggat ggggtgctta caggagcagc agggctgagg   1740

gagatgacag cagtacgaac cgtggctctc ctgaggcctg ggtttcctca tatgtaaaat   1800

gggggttgca ttagaccata cccttggcct gtgtttaggc aaatagggat gaaagtgggg   1860

ccaagggctg aagagctggg tccgctgccg tcgttgccct tctttcttgc caggtgagtg   1920

acttgcgcaa tcaggtctac ctggaggatg gactggaccc cttcccaggc gagggccgtg   1980

tggtgggcag gcagctgatg cacaaggcct tggacagggt ggaggagcac ccaggctcca   2040

ggatgactgc tgagaaattt ctgaacaggc tccccaagtt tgtgatccgg caaggcgagg   2100

tgattgacat ccggggcccc atcagggaca ccttgcagaa ctgctgccca ttgcctgccc   2160

ggatccagga gattgtggtg gagacgccca ccttggccgc tgagcgagag aggagccagg   2220

agtcacccaa cacgccggca cccccgctct ccatgctgcg catcaagtct gagaatgggg   2280

aacaggcctt cctactgatg atgcagcctg acaacaccat tggggacgtg cgagctctgc   2340

tagcgcaggc cagggtcatg gatgcctctg cctttgagat cttcagcaca ttcccgccca   2400

ccctctacca ggacgataca ctcacgctgc aggctgcagg ccttgtgccc aaagcagcac   2460

tgctgctgcg ggcacgccga gccccgaagt ccagcctgaa attcagtcct ggtccctgtc   2520

ccggtcccgg tcccggcccc agtcccggtc ccggtcccgg ccccagtccc ggtcccggtc   2580

ccggccccag tccctgtcct ggacccagtc ccagccccca ataaagcacc cgccccctca   2640

ac                                                                  2642


<210>  5695
<211>  324
<212>  PRT
<213>  Homosapiens

<400>  5695

Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Glu Asp Glu Val Asp Met Leu Ser Asp Gly Cys Gly Ser Glu Glu 
        35                  40                  45              


Lys Ile Ser Val Pro Ser Cys Tyr Gly Gly Ile Gly Ala Pro Val Ser 
    50                  55                  60                  


Arg Gln Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr 
65                  70                  75                  80  


Arg Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu 
                85                  90                  95      


Ile Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln 
            100                 105                 110         


Thr Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu 
        115                 120                 125             


Leu Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu 
    130                 135                 140                 


Arg Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp 
145                 150                 155                 160 


Gln Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp 
                165                 170                 175     


Trp Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro 
            180                 185                 190         


Pro Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser 
        195                 200                 205             


Glu Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly 
    210                 215                 220                 


Ala Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn 
225                 230                 235                 240 


Gly Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser 
                245                 250                 255     


Thr Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu 
            260                 265                 270         


Leu Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ile Ser Cys 
        275                 280                 285             


Ser Ser Asn His Thr Phe Gly Asp Phe Glu Gly Ser Gly Asp Thr Gln 
    290                 295                 300                 


Pro Pro Gln Thr Pro Pro Ile Leu Arg Gly Ser Arg Cys Thr Pro Trp 
305                 310                 315                 320 


Gly Thr Pro Val 
                


<210>  5696
<211>  1642
<212>  DNA
<213>  Homosapiens

<400>  5696
gtactttccc aagcaccacc aggccaaagg tctctcagtt cagagcagaa agccgtatac     60

ccagaggagc aggcagataa cagaaacttc cagaaacctc tgtggagaca gtggaagagg    120

caaaagggag ttcctgacag ctggattcta gaagtagaac tatgagctca cctttggcct    180

cccttagcaa gacccgaaaa gtgcccctgc cctcggagcc tatgaatcct gggaggcgag    240

gaatccgcat ctatggagat gtccctgcat cccatgactc ggagctgatg gccttcatga    300

cgaggaagtt gtgggacctg gagcagcagg tgaaggccca gactgatgag atactgtcca    360

aggatcagaa gatagcggcc ctagaggacc tggtgcagac cctccggcca cacccagccg    420

aggcaaccct gcagcggcag gaggaactgg agacgatgtg tgtgcagctg cagcggcagg    480

tcagggagat ggagcggttc ctcagtgact atggcctgca gtgggtgggc gagcccatgg    540

accaggagga ctcagagagc aagacagtct cagagcatgg cgagagggac tggatgacag    600

ccaagaagtt ctggaagcca ggggactcat tggcgccccc tgaggtggac tttgacaggc    660

tgctggccag cctgcaggat cttagtgagc tggtggtaga gggtgacacc caagtgacac    720

cagtgcccgg cggggcacgg ctgcgtaccc tcgagcccat cccgctgaag ctctaccgga    780

atggcatcat gatgttcgac gggcccttcc agcccttcta cgatccctcc acacagcgct    840

gcctccgaga catattggat ggcttctttc cctcagagct ccagcgactg taccccaatg    900

gggtcccctt taaggtgagt gacttgcgca atcaggtcta cctggaggat ggactggacc    960

ccttcccagg cgagggccgt gtggtgggca ggcagctgat gcacaaggcc ttggacaggg   1020

tggaggagca cccaggctcc aggatgactg ctgagaaatt tctgaacagg ctccccaagt   1080

ttgtgatccg gcaaggcgag gtgattgaca tccggggccc catcagggac accttgcaga   1140

actgctgccc attgcctgcc cggatccagg agattgtggt ggagacgccc accttggccg   1200

ctgagcgaga gaggagccag gagtcaccca acacgccggc acccccgctc tccatgctgc   1260

gcatcaagtc tgagaatggg gaacaggcct tcctactgat gatgcagcct gacaacacca   1320

ttggggacgt gcgagctctg ctagcgcagg ccagggtcat ggatgcctct gcctttgaga   1380

tcttcagcac attcccgccc accctctacc aggacgatac actcacgctg caggctgcag   1440

gccttgtgcc caaagcagca ctgctgctgc gggcacgccg agccccgaag tccagcctga   1500

aattcagtcc tggtccctgt cccggtcccg gtcccggccc cagtcccggt cccggtcccg   1560

gccccagtcc cggtcccggt cccggcccca gtccctgtcc tggacccagt cccagccccc   1620

aataaagcac ccgccccctc aa                                            1642


<210>  5697
<211>  487
<212>  PRT
<213>  Homosapiens

<400>  5697

Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr Arg 
        35                  40                  45              


Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu Ile 
    50                  55                  60                  


Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln Thr 
65                  70                  75                  80  


Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu Leu 
                85                  90                  95      


Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu Arg 
            100                 105                 110         


Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp Gln 
        115                 120                 125             


Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp Trp 
    130                 135                 140                 


Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro Pro 
145                 150                 155                 160 


Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser Glu 
                165                 170                 175     


Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly Ala 
            180                 185                 190         


Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn Gly 
        195                 200                 205             


Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser Thr 
    210                 215                 220                 


Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu Leu 
225                 230                 235                 240 


Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu Arg 
                245                 250                 255     


Asn Gln Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu Gly 
            260                 265                 270         


Arg Val Val Gly Arg Gln Leu Met His Lys Ala Leu Asp Arg Val Glu 
        275                 280                 285             


Glu His Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg Leu 
    290                 295                 300                 


Pro Lys Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly Pro 
305                 310                 315                 320 


Ile Arg Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile Gln 
                325                 330                 335     


Glu Ile Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg Ser 
            340                 345                 350         


Gln Glu Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg Ile 
        355                 360                 365             


Lys Ser Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro Asp 
    370                 375                 380                 


Asn Thr Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val Met 
385                 390                 395                 400 


Asp Ala Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu Tyr 
                405                 410                 415     


Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys Ala 
            420                 425                 430         


Ala Leu Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys Phe 
        435                 440                 445             


Ser Pro Gly Pro Cys Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly Pro 
    450                 455                 460                 


Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys Pro 
465                 470                 475                 480 


Gly Pro Ser Pro Ser Pro Gln 
                485         


<210>  5698
<211>  2327
<212>  DNA
<213>  Homosapiens

<400>  5698
aacaagatgg cggcgctgcg ggacggctag cggccctgcg tgtccctgca tcccatgact     60

cggagctgat ggccttcatg acgaggaagt tgtgggacct ggagcagcag gtgaaggccc    120

agactgatga gatactgtcc aaggatcaga agatagcggc cctagaggac ctggtgcaga    180

ccctccggcc acacccagcg gttcctcagt gactatggcc tgcagtgggt gggcgagccc    240

atggaccagg aggactcaga gagcaagaca gtctcagagc atggcgagag ggactggatg    300

acagccaaga agttctggaa gccaggggac tcattggcgc cccctgaggt ggactttgac    360

aggctgctgg ccagcctgca ggatcttagt gagctggtgg tagagggtga cacccaagtg    420

acaccagtgc ccggcggggc acggctgcgt accctcgagc ccatcccgct gaagctctac    480

cggaatggca tcatgatgtt cgacgggccc ttccagccct tctacgatcc ctccacacag    540

cgctgcctcc gagacatatt ggatggcttc tttccctcag agctccagcg actgtacccc    600

aatggggtcc cctttaaggt gataagctgc tcctcaaacc acacctttgg ggattttgaa    660

gggagtgggg atacacagcc tccccagaca cctcccattc tgaggggaag ccgctgcact    720

ccctggggga ccccagtctg atgccctcca ggaggataag tctgaagccg ggctgggaag    780

ggagcggaga ggcccgaaac agagcagcag gcagcgccct ctgctggcac cctggagaca    840

gcctcggctg cggggcccct gccttctagt cctccccagc tttcaggaca ccttgacaac    900

ctggggtccc tgcagaagtg gcccggctgt cccccaagtc tcctgaagct atctgggtag    960

ggtgggaggc agtgctgtga gccacaaatg caaagcagag gggacagatg ttgggactca   1020

aagacatgag gtagagctgg ccccatgggt aggtgccacc accagagccc atgaggcttc   1080

gtgttctaga aggtggtggg ttagtgccgc actgagggcg tgtccgggag ggagcatgtg   1140

tcaccagggc tcaggaaaca gcatgagtca tgacgcgggg gtgtttaagg cattcgtgcc   1200

acagcgggga cctcggagct atgccttgat aaggcaagtg aggttacatg tacgatgatg   1260

cggtttgtgc tgcagactgg aaaaaagcag gggctttgtc ctctcctgac cccctcacac   1320

tctgccttca cggtaggctc ctgagagggg ggtctccaag gagggtgtca gtactgcagc   1380

ttcagctggc gtggatgggg tgcttacagg agcagcaggg ctgagggaga tgacagcagt   1440

acgaaccgtg gctctcctga ggcctgggtt tcctcatatg taaaatgggg gttgcattag   1500

accataccct tggcctgtgt ttaggcaaat agggatgaaa gtggggccaa gggctgaaga   1560

gctgggtccg ctgccgtcgt tgcccttctt tcttgccagg tgagtgactt gcgcaatcag   1620

gtctacctgg aggatggact ggaccccttc ccaggcgagg gccgtgtggt gggcaggcag   1680

ctgatgcaca aggccttgga cagggtggag gagcacccag gctccaggat gactgctgag   1740

aaatttctga acaggctccc caagtttgtg atccggcaag gcgaggtgat tgacatccgg   1800

ggccccatca gggacacctt gcagaactgc tgcccattgc ctgcccggat ccaggagatt   1860

gtggtggaga cgcccacctt ggccgctgag cgagagagga gccaggagtc acccaacacg   1920

ccggcacccc cgctctccat gctgcgcatc aagtctgaga atggggaaca ggccttccta   1980

ctgatgatgc agcctgacaa caccattggg gacgtgcgag ctctgctagc gcaggccagg   2040

gtcatggatg cctctgcctt tgagatcttc agcacattcc cgcccaccct ctaccaggac   2100

gatacactca cgctgcaggc tgcaggcctt gtgcccaaag cagcactgct gctgcgggca   2160

cgccgagccc cgaagtccag cctgaaattc agtcctggtc cctgtcccgg tcccggtccc   2220

ggccccagtc ccggtcccgg tcccggcccc agtcccggtc ccggtcccgg ccccagtccc   2280

tgtcctggac ccagtcccag cccccaataa agcacccgcc ccctcaa                 2327


<210>  5699
<211>  208
<212>  PRT
<213>  Homosapiens

<400>  5699

Met His Lys Ala Leu Asp Arg Val Glu Glu His Pro Gly Ser Arg Met 
1               5                   10                  15      


Thr Ala Glu Lys Phe Leu Asn Arg Leu Pro Lys Phe Val Ile Arg Gln 
            20                  25                  30          


Gly Glu Val Ile Asp Ile Arg Gly Pro Ile Arg Asp Thr Leu Gln Asn 
        35                  40                  45              


Cys Cys Pro Leu Pro Ala Arg Ile Gln Glu Ile Val Val Glu Thr Pro 
    50                  55                  60                  


Thr Leu Ala Ala Glu Arg Glu Arg Ser Gln Glu Ser Pro Asn Thr Pro 
65                  70                  75                  80  


Ala Pro Pro Leu Ser Met Leu Arg Ile Lys Ser Glu Asn Gly Glu Gln 
                85                  90                  95      


Ala Phe Leu Leu Met Met Gln Pro Asp Asn Thr Ile Gly Asp Val Arg 
            100                 105                 110         


Ala Leu Leu Ala Gln Ala Arg Val Met Asp Ala Ser Ala Phe Glu Ile 
        115                 120                 125             


Phe Ser Thr Phe Pro Pro Thr Leu Tyr Gln Asp Asp Thr Leu Thr Leu 
    130                 135                 140                 


Gln Ala Ala Gly Leu Val Pro Lys Ala Ala Leu Leu Leu Arg Ala Arg 
145                 150                 155                 160 


Arg Ala Pro Lys Ser Ser Leu Lys Phe Ser Pro Gly Pro Cys Pro Gly 
                165                 170                 175     


Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly 
            180                 185                 190         


Pro Gly Pro Gly Pro Ser Pro Cys Pro Gly Pro Ser Pro Ser Pro Gln 
        195                 200                 205             


<210>  5700
<211>  2542
<212>  DNA
<213>  Homosapiens

<400>  5700
gacaacaaga tggcggcgct gcgggacggc tagcggccct gcgtgggagt tcctgacagc     60

tggattctag aagtagaact atgagctcac ctttggcctc ccttagcaag acccgaaaag    120

tgcccctgcc ctcggagcct atgaatcctg ggaggcgagg aatccgcatc tatggagatg    180

tccctgcatc ccatgactcg gagctgatgg ccttcatgac gaggaagttg tgggacctgg    240

agcagcaggt gaaggcccag actgatgaga tactgtccaa ggatcagaag atagcggccc    300

tagaggacct ggtgcagacc ctccggccac acccagccga ggcaaccctg cagcggcagg    360

aggaactgga gacgatgtgt gtgcagctgc agcggcaggt cagggagatg gagcggttcc    420

tcagtgacta tggcctgcag tgggtgggcg agcccatgga ccaggaggac tcagagagca    480

agacagtctc agagcatggc gagagggact ggatgacagc caagaagttc tggaagccag    540

gggactcatt ggcgccccct gaggtggact ttgacaggct gctggccagc ctgcaggatc    600

ttagtgagct ggtggtagag ggtgacaccc aagtgacacc agtgcccggc ggggcacggc    660

tgcgtaccct cgagcccatc ccgctgaagc tctaccggaa tggcatcatg atgttcgacg    720

ggcccttcca gcccttctac gatccctcca cacagcgctg cctccgagac atattggatg    780

gcttctttcc ctcagagctc cagcgactgt accccaatgg ggtccccttt aaggtgataa    840

gctgctcctc aaaccacacc tttggggatt ttgaagggag tggggataca cagcctcccc    900

agacacctcc cattctgagg ggaagccgct gcactccctg ggggacccca gtctgatgcc    960

ctccaggagg ataagtctga agccgggctg ggaagggagc ggagaggccc gaaacagagc   1020

agcaggcagc gccctctgct ggcaccctgg agacagcctc ggctgcgggg cccctgcctt   1080

ctagtcctcc ccagctttca ggacaccttg acaacctggg gtccctgcag aagtggcccg   1140

gctgtccccc aagtctcctg aagctatctg ggtagggtgg gaggcagtgc tgtgagccac   1200

aaatgcaaag cagaggggac agatgttggg actcaaagac atgaggtaga gctggcccca   1260

tgggtaggtg ccaccaccag agcccatgag gcttcgtgtt ctagaaggtg gtgggttagt   1320

gccgcactga gggcgtgtcc gggagggagc atgtgtcacc agggctcagg aaacagcatg   1380

agtcatgacg cgggggtgtt taaggcattc gtgccacagc ggggacctcg gagctatgcc   1440

ttgataaggc aagtgaggtt acatgtacga tgatgcggtt tgtgctgcag actggaaaaa   1500

agcaggggct ttgtcctctc ctgaccccct cacactctgc cttcacggta ggctcctgag   1560

aggggggtct ccaaggaggg tgtcagtact gcagcttcag ctggcgtgga tggggtgctt   1620

acaggagcag cagggctgag ggagatgaca gcagtacgaa ccgtggctct cctgaggcct   1680

gggtttcctc atatgtaaaa tgggggttgc attagaccat acccttggcc tgtgtttagg   1740

caaataggga tgaaagtggg gccaagggct gaagagctgg gtccgctgcc gtcgttgccc   1800

ttctttcttg ccaggtgagt gacttgcgca atcaggtcta cctggaggat ggactggacc   1860

ccttcccagg cgagggccgt gtggtgggca ggcagctgat gcacaaggcc ttggacaggg   1920

tggaggagca cccaggctcc aggatgactg ctgagaaatt tctgaacagg ctccccaagt   1980

ttgtgatccg gcaaggcgag gtgattgaca tccggggccc catcagggac accttgcaga   2040

actgctgccc attgcctgcc cggatccagg agattgtggt ggagacgccc accttggccg   2100

ctgagcgaga gaggagccag gagtcaccca acacgccggc acccccgctc tccatgctgc   2160

gcatcaagtc tgagaatggg gaacaggcct tcctactgat gatgcagcct gacaacacca   2220

ttggggacgt gcgagctctg ctagcgcagg ccagggtcat ggatgcctct gcctttgaga   2280

tcttcagcac attcccgccc accctctacc aggacgatac actcacgctg caggctgcag   2340

gccttgtgcc caaagcagca ctgctgctgc gggcacgccg agccccgaag tccagcctga   2400

aattcagtcc tggtccctgt cccggtcccg gtcccggccc cagtcccggt cccggtcccg   2460

gccccagtcc cggtcccggt cccggcccca gtccctgtcc tggacccagt cccagccccc   2520

aataaagcac ccgccccctc aa                                            2542


<210>  5701
<211>  291
<212>  PRT
<213>  Homosapiens

<400>  5701

Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr Arg 
        35                  40                  45              


Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu Ile 
    50                  55                  60                  


Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln Thr 
65                  70                  75                  80  


Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu Leu 
                85                  90                  95      


Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu Arg 
            100                 105                 110         


Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp Gln 
        115                 120                 125             


Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp Trp 
    130                 135                 140                 


Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro Pro 
145                 150                 155                 160 


Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser Glu 
                165                 170                 175     


Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly Ala 
            180                 185                 190         


Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn Gly 
        195                 200                 205             


Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser Thr 
    210                 215                 220                 


Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu Leu 
225                 230                 235                 240 


Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ile Ser Cys Ser 
                245                 250                 255     


Ser Asn His Thr Phe Gly Asp Phe Glu Gly Ser Gly Asp Thr Gln Pro 
            260                 265                 270         


Pro Gln Thr Pro Pro Ile Leu Arg Gly Ser Arg Cys Thr Pro Trp Gly 
        275                 280                 285             


Thr Pro Val 
    290     


<210>  5702
<211>  1794
<212>  DNA
<213>  Homosapiens

<400>  5702
aaaccgcgtg acaacaagat ggcggcgctg cgggacggct agcggccctg cgtgtacttt     60

cccaagcacc accaggccaa aggtctctca gttcagagca gaaagccgta tacccagagg    120

agcaggcaga taacagaaac ttccagaaac ctctgtggag acagtggaag aggcaaaagg    180

gagttcctga cagctggatt ctagaagtag aactatgagc tcacctttgg cctcccttag    240

caagacccga aaagtgcccc tgccctcgga gcctatgaat cctgggaggc gaggaatccg    300

catctatgga gatgaagatg aggtggacat gttgagtgat gggtgtggct cagaagaaaa    360

gatctcagtc ccttcctgct atggcggcat aggtgcccct gtgagtcggc aagtccctgc    420

atcccatgac tcggagctga tggccttcat gacgaggaag ttgtgggacc tggagcagca    480

ggtgaaggcc cagactgatg agatactgtc caaggatcag aagatagcgg ccctagagga    540

cctggtgcag accctccggc cacacccagc cgaggcaacc ctgcagcggc aggaggaact    600

ggagacgatg tgtgtgcagc tgcagcggca ggtcagggag atggagcggt tcctcagtga    660

ctatggcctg cagtgggtgg gcgagcccat ggaccaggag gactcagaga gcaagacagt    720

ctcagagcat ggcgagaggg actggatgac agccaagaag ttctggaagc caggggactc    780

attggcgccc cctgaggtgg actttgacag gctgctggcc agcctgcagg atcttagtga    840

gctggtggta gagggtgaca cccaagtgac accagtgccc ggcggggcac ggctgcgtac    900

cctcgagccc atcccgctga agctctaccg gaatggcatc atgatgttcg acgggccctt    960

ccagcccttc tacgatccct ccacacagcg ctgcctccga gacatattgg atggcttctt   1020

tccctcagag ctccagcgac tgtaccccaa tggggtcccc tttaaggtga gtgacttgcg   1080

caatcaggtc tacctggagg atggactgga ccccttccca ggcgagggcc gtgtggtggg   1140

caggcagctg atgcacaagg ccttggacag ggtggaggag cacccaggct ccaggatgac   1200

tgctgagaaa tttctgaaca ggctccccaa gtttgtgatc cggcaaggcg aggtgattga   1260

catccggggc cccatcaggg acaccttgca gaactgctgc ccattgcctg cccggatcca   1320

ggagattgtg gtggagacgc ccaccttggc cgctgagcga gagaggagcc aggagtcacc   1380

caacacgccg gcacccccgc tctccatgct gcgcatcaag tctgagaatg gggaacaggc   1440

cttcctactg atgatgcagc ctgacaacac cattggggac gtgcgagctc tgctagcgca   1500

ggccagggtc atggatgcct ctgcctttga gatcttcagc acattcccgc ccaccctcta   1560

ccaggacgat acactcacgc tgcaggctgc aggccttgtg cccaaagcag cactgctgct   1620

gcgggcacgc cgagccccga agtccagcct gaaattcagt cctggtccct gtcccggtcc   1680

cggtcccggc cccagtcccg gtcccggtcc cggccccagt cccggtcccg gtcccggccc   1740

cagtccctgt cctggaccca gtcccagccc ccaataaagc acccgccccc tcaa         1794


<210>  5703
<211>  520
<212>  PRT
<213>  Homosapiens

<400>  5703

Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Glu Asp Glu Val Asp Met Leu Ser Asp Gly Cys Gly Ser Glu Glu 
        35                  40                  45              


Lys Ile Ser Val Pro Ser Cys Tyr Gly Gly Ile Gly Ala Pro Val Ser 
    50                  55                  60                  


Arg Gln Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr 
65                  70                  75                  80  


Arg Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu 
                85                  90                  95      


Ile Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln 
            100                 105                 110         


Thr Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu 
        115                 120                 125             


Leu Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu 
    130                 135                 140                 


Arg Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp 
145                 150                 155                 160 


Gln Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp 
                165                 170                 175     


Trp Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro 
            180                 185                 190         


Pro Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser 
        195                 200                 205             


Glu Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly 
    210                 215                 220                 


Ala Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn 
225                 230                 235                 240 


Gly Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser 
                245                 250                 255     


Thr Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu 
            260                 265                 270         


Leu Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu 
        275                 280                 285             


Arg Asn Gln Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu 
    290                 295                 300                 


Gly Arg Val Val Gly Arg Gln Leu Met His Lys Ala Leu Asp Arg Val 
305                 310                 315                 320 


Glu Glu His Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg 
                325                 330                 335     


Leu Pro Lys Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly 
            340                 345                 350         


Pro Ile Arg Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile 
        355                 360                 365             


Gln Glu Ile Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg 
    370                 375                 380                 


Ser Gln Glu Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg 
385                 390                 395                 400 


Ile Lys Ser Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro 
                405                 410                 415     


Asp Asn Thr Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val 
            420                 425                 430         


Met Asp Ala Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu 
        435                 440                 445             


Tyr Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys 
    450                 455                 460                 


Ala Ala Leu Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys 
465                 470                 475                 480 


Phe Ser Pro Gly Pro Cys Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly 
                485                 490                 495     


Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys 
            500                 505                 510         


Pro Gly Pro Ser Pro Ser Pro Gln 
        515                 520 


<210>  5704
<211>  1337
<212>  DNA
<213>  Homosapiens

<400>  5704
aaaccgcgtg acaacaagat ggcggcgctg cgggacggct agcggccctg cgtggaggcg     60

aggaatccgc atctatggag atgtccctgc atcccatgac tcggagctga tggccttcat    120

gacgaggaag ttgtgggacc tggagcagca ggtgaaggcc cagactgatg agatactgtc    180

caaggatcag aagatagcgg ccctagagga cctggtgcag accctccggc cacacccagc    240

cgaggcaacc ctgcagcggc aggaggaact ggagacgatg tgtgtgcagc tgcagcggca    300

ggtcagggag atggagggga ctcattggcg ccccctgagg tggactttga caggctgctg    360

gccagcctgc aggatcttag tgagctggtg gtagagggtg acacccaagt gacaccagtg    420

cccggcgggg cacggctgcg taccctcgag cccatcccgc tgaagctcta ccggaatggc    480

atcatgatgt tcgacgggcc cttccagccc ttctacgatc cctccacaca gcgctgcctc    540

cgagacatat tggatggctt ctttccctca gagctccagc gactgtaccc caatggggtc    600

ccctttaagg tgagtgactt gcgcaatcag gtctacctgg aggatggact ggaccccttc    660

ccaggcgagg gccgtgtggt gggcaggcag ctgatgcaca aggccttgga cagggtggag    720

gagcacccag gctccaggat gactgctgag aaatttctga acaggctccc caagtttgtg    780

atccggcaag gcgaggtgat tgacatccgg ggccccatca gggacacctt gcagaactgc    840

tgcccattgc ctgcccggat ccaggagatt gtggtggaga cgcccacctt ggccgctgag    900

cgagagagga gccaggagtc acccaacacg ccggcacccc cgctctccat gctgcgcatc    960

aagtctgaga atggggaaca ggccttccta ctgatgatgc agcctgacaa caccattggg   1020

gacgtgcgag ctctgctagc gcaggccagg gtcatggatg cctctgcctt tgagatcttc   1080

agcacattcc cgcccaccct ctaccaggac gatacactca cgctgcaggc tgcaggcctt   1140

gtgcccaaag cagcactgct gctgcgggca cgccgagccc cgaagtccag cctgaaattc   1200

agtcctggtc cctgtcccgg tcccggtccc ggccccagtc ccggtcccgg tcccggcccc   1260

agtcccggtc ccggtcccgg ccccagtccc tgtcctggac ccagtcccag cccccaataa   1320

agcacccgcc ccctcaa                                                  1337


<210>  5705
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  5705

Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser Thr Gln 
1               5                   10                  15      


Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu Leu Gln 
            20                  25                  30          


Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu Arg Asn 
        35                  40                  45              


Gln Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu Gly Arg 
    50                  55                  60                  


Val Val Gly Arg Gln Leu Met His Lys Ala Leu Asp Arg Val Glu Glu 
65                  70                  75                  80  


His Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg Leu Pro 
                85                  90                  95      


Lys Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly Pro Ile 
            100                 105                 110         


Arg Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile Gln Glu 
        115                 120                 125             


Ile Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg Ser Gln 
    130                 135                 140                 


Glu Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg Ile Lys 
145                 150                 155                 160 


Ser Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro Asp Asn 
                165                 170                 175     


Thr Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val Met Asp 
            180                 185                 190         


Ala Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu Tyr Gln 
        195                 200                 205             


Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys Ala Ala 
    210                 215                 220                 


Leu Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys Phe Ser 
225                 230                 235                 240 


Pro Gly Pro Cys Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly 
                245                 250                 255     


Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys Pro Gly 
            260                 265                 270         


Pro Ser Pro Ser Pro Gln 
        275             


<210>  5706
<211>  1103
<212>  DNA
<213>  Homosapiens

<400>  5706
agaagtgcac gggtcctggt cgcctaggaa accgcgtgac aacaagatgg cggcgctgcg     60

ggacggctag cggccctgcg tggggactca ttggcgcccc ctgaggtgga ctttgacagg    120

ctgctggcca gcctgcagga tcttagtgag ctggtggtag agggtgacac ccaagtgaca    180

ccagtgcccg gcggggcacg gctgcgtacc ctcgagccca tcccgctgaa gctctaccgg    240

aatggcatca tgatgttcga cgggcccttc cagcccttct acgatccctc cacacagcgc    300

tgcctccgag acatattgga tggcttcttt ccctcagagc tccagcgact gtaccccaat    360

ggggtcccct ttaaggtgag tgacttgcgc aatcaggtct acctggagga tggactggac    420

cccttcccag gcgagggccg tgtggtgggc aggcagctga tgcacaaggc cttggacagg    480

gtggaggagc acccaggctc caggatgact gctgagaaat ttctgaacag gctccccaag    540

tttgtgatcc ggcaaggcga ggtgattgac atccggggcc ccatcaggga caccttgcag    600

aactgctgcc cattgcctgc ccggatccag gagattgtgg tggagacgcc caccttggcc    660

gctgagcgag agaggagcca ggagtcaccc aacacgccgg cacccccgct ctccatgctg    720

cgcatcaagt ctgagaatgg ggaacaggcc ttcctactga tgatgcagcc tgacaacacc    780

attggggacg tgcgagctct gctagcgcag gccagggtca tggatgcctc tgcctttgag    840

atcttcagca cattcccgcc caccctctac caggacgata cactcacgct gcaggctgca    900

ggccttgtgc ccaaagcagc actgctgctg cgggcacgcc gagccccgaa gtccagcctg    960

aaattcagtc ctggtccctg tcccggtccc ggtcccggcc ccagtcccgg tcccggtccc   1020

ggccccagtc ccggtcccgg tcccggcccc agtccctgtc ctggacccag tcccagcccc   1080

caataaagca cccgccccct caa                                           1103


<210>  5707
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  5707

Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser Thr Gln 
1               5                   10                  15      


Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu Leu Gln 
            20                  25                  30          


Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu Arg Asn 
        35                  40                  45              


Gln Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu Gly Arg 
    50                  55                  60                  


Val Val Gly Arg Gln Leu Met His Lys Ala Leu Asp Arg Val Glu Glu 
65                  70                  75                  80  


His Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg Leu Pro 
                85                  90                  95      


Lys Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly Pro Ile 
            100                 105                 110         


Arg Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile Gln Glu 
        115                 120                 125             


Ile Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg Ser Gln 
    130                 135                 140                 


Glu Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg Ile Lys 
145                 150                 155                 160 


Ser Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro Asp Asn 
                165                 170                 175     


Thr Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val Met Asp 
            180                 185                 190         


Ala Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu Tyr Gln 
        195                 200                 205             


Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys Ala Ala 
    210                 215                 220                 


Leu Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys Phe Ser 
225                 230                 235                 240 


Pro Gly Pro Cys Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly Pro Gly 
                245                 250                 255     


Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys Pro Gly 
            260                 265                 270         


Pro Ser Pro Ser Pro Gln 
        275             


<210>  5708
<211>  2357
<212>  DNA
<213>  Homosapiens

<400>  5708
tgtccttaat gcttgatgga gctgcaacta gaactgttct tgatggagat taagctggtt     60

ttgatggtga tcaagctgtt cttgatcaag aacttgatgg ctccggtctg ctgtactgac    120

tcccctctgg gcacctggga tgctaccaaa gctgcctcct ggaatagcag tcgcttttga    180

gactccagtt gtttctgaaa tgggagagtc ctgtcttctt tgcattcctg aacatccagg    240

cttctctctg gcaggggagt gggggttaga gtgtcccctg tcacctccat aaccacagca    300

ggctccactt ggacatctcc tggcctctcc ccaaaggacc atctccccag actccctgtg    360

ggccgatgcc ttcctcactc agggttgtct tcccaagtct cttagttctc tattattcca    420

caacacccct tgggtgcccc aacgcgccta gcaccctgta agtgctcccc agctgtggat    480

acaggtttct ctcagggcag cccgcaagca gtgcagcccc agccagaaga gctggaaggc    540

tgggcggcca ggcccgctgt gtccccagtt ttcctgttgg agtccatctg ctgtgctctc    600

aggagagaag gctgggtctc tgggagctca catcctgtat gccctccctc catgccaagc    660

aactttgggg agtcctggca gtggtgccag gcgttgctct tacctgtacc ataaccagga    720

ggctgatggt tgctcaggcc tccctcaaac tagccaatga gaagtgcacg ggtcctggtc    780

gcctaggaaa ccgcgtgaca acaagatggc ggcgctgcgg gacggctagc ggccctgcgt    840

gggagttcct gacagctgga ttctagaagt agaactatga gctcaccttt ggcctccctt    900

agcaagaccc gaaaagtgcc cctgccctcg gagcctatga atcctgggag gcgaggaatc    960

cgcatctatg gagatgtccc tgcatcccat gactcggagc tgatggcctt catgacgagg   1020

aagttgtggg acctggagca gcaggtgaag gcccagactg atgagatact gtccaaggat   1080

cagaagatag cggccctaga ggacctggtg cagaccctcc ggccacaccc agccgaggca   1140

accctgcagc ggcaggagga actggagacg atgtgtgtgc agctgcagcg gcaggtcagg   1200

gagatggagc ggttcctcag tgactatggc ctgcagtggg tgggcgagcc catggaccag   1260

gaggactcag agagcaagac agtctcagag catggcgaga gggactggat gacagccaag   1320

aagttctgga agccagggga ctcattggcg ccccctgagg tggactttga caggctgctg   1380

gccagcctgc aggatcttag tgagctggtg gtagagggtg acacccaagt gacaccagtg   1440

cccggcgggg cacggctgcg taccctcgag cccatcccgc tgaagctcta ccggaatggc   1500

atcatgatgt tcgacgggcc cttccagccc ttctacgatc cctccacaca gcgctgcctc   1560

cgagacatat tggatggctt ctttccctca gagctccagc gactgtaccc caatggggtc   1620

ccctttaagg tgagtgactt gcgcaatcag gtctacctgg aggatggact ggaccccttc   1680

ccaggcgagg gccgtgtggt gggcaggcag ctgatgcaca aggccttgga cagggtggag   1740

gagcacccag gctccaggat gactgctgag aaatttctga acaggctccc caagtttgtg   1800

atccggcaag gcgaggtgat tgacatccgg ggccccatca gggacacctt gcagaactgc   1860

tgcccattgc ctgcccggat ccaggagatt gtggtggaga cgcccacctt ggccgctgag   1920

cgagagagga gccaggagtc acccaacacg ccggcacccc cgctctccat gctgcgcatc   1980

aagtctgaga atggggaaca ggccttccta ctgatgatgc agcctgacaa caccattggg   2040

gacgtgcgag ctctgctagc gcaggccagg gtcatggatg cctctgcctt tgagatcttc   2100

agcacattcc cgcccaccct ctaccaggac gatacactca cgctgcaggc tgcaggcctt   2160

gtgcccaaag cagcactgct gctgcgggca cgccgagccc cgaagtccag cctgaaattc   2220

agtcctggtc cctgtcccgg tcccggtccc ggccccagtc ccggtcccgg tcccggcccc   2280

agtcccggtc ccggtcccgg ccccagtccc tgtcctggac ccagtcccag cccccaataa   2340

agcacccgcc ccctcaa                                                  2357


<210>  5709
<211>  487
<212>  PRT
<213>  Homosapiens

<400>  5709

Met Ser Ser Pro Leu Ala Ser Leu Ser Lys Thr Arg Lys Val Pro Leu 
1               5                   10                  15      


Pro Ser Glu Pro Met Asn Pro Gly Arg Arg Gly Ile Arg Ile Tyr Gly 
            20                  25                  30          


Asp Val Pro Ala Ser His Asp Ser Glu Leu Met Ala Phe Met Thr Arg 
        35                  40                  45              


Lys Leu Trp Asp Leu Glu Gln Gln Val Lys Ala Gln Thr Asp Glu Ile 
    50                  55                  60                  


Leu Ser Lys Asp Gln Lys Ile Ala Ala Leu Glu Asp Leu Val Gln Thr 
65                  70                  75                  80  


Leu Arg Pro His Pro Ala Glu Ala Thr Leu Gln Arg Gln Glu Glu Leu 
                85                  90                  95      


Glu Thr Met Cys Val Gln Leu Gln Arg Gln Val Arg Glu Met Glu Arg 
            100                 105                 110         


Phe Leu Ser Asp Tyr Gly Leu Gln Trp Val Gly Glu Pro Met Asp Gln 
        115                 120                 125             


Glu Asp Ser Glu Ser Lys Thr Val Ser Glu His Gly Glu Arg Asp Trp 
    130                 135                 140                 


Met Thr Ala Lys Lys Phe Trp Lys Pro Gly Asp Ser Leu Ala Pro Pro 
145                 150                 155                 160 


Glu Val Asp Phe Asp Arg Leu Leu Ala Ser Leu Gln Asp Leu Ser Glu 
                165                 170                 175     


Leu Val Val Glu Gly Asp Thr Gln Val Thr Pro Val Pro Gly Gly Ala 
            180                 185                 190         


Arg Leu Arg Thr Leu Glu Pro Ile Pro Leu Lys Leu Tyr Arg Asn Gly 
        195                 200                 205             


Ile Met Met Phe Asp Gly Pro Phe Gln Pro Phe Tyr Asp Pro Ser Thr 
    210                 215                 220                 


Gln Arg Cys Leu Arg Asp Ile Leu Asp Gly Phe Phe Pro Ser Glu Leu 
225                 230                 235                 240 


Gln Arg Leu Tyr Pro Asn Gly Val Pro Phe Lys Val Ser Asp Leu Arg 
                245                 250                 255     


Asn Gln Val Tyr Leu Glu Asp Gly Leu Asp Pro Phe Pro Gly Glu Gly 
            260                 265                 270         


Arg Val Val Gly Arg Gln Leu Met His Lys Ala Leu Asp Arg Val Glu 
        275                 280                 285             


Glu His Pro Gly Ser Arg Met Thr Ala Glu Lys Phe Leu Asn Arg Leu 
    290                 295                 300                 


Pro Lys Phe Val Ile Arg Gln Gly Glu Val Ile Asp Ile Arg Gly Pro 
305                 310                 315                 320 


Ile Arg Asp Thr Leu Gln Asn Cys Cys Pro Leu Pro Ala Arg Ile Gln 
                325                 330                 335     


Glu Ile Val Val Glu Thr Pro Thr Leu Ala Ala Glu Arg Glu Arg Ser 
            340                 345                 350         


Gln Glu Ser Pro Asn Thr Pro Ala Pro Pro Leu Ser Met Leu Arg Ile 
        355                 360                 365             


Lys Ser Glu Asn Gly Glu Gln Ala Phe Leu Leu Met Met Gln Pro Asp 
    370                 375                 380                 


Asn Thr Ile Gly Asp Val Arg Ala Leu Leu Ala Gln Ala Arg Val Met 
385                 390                 395                 400 


Asp Ala Ser Ala Phe Glu Ile Phe Ser Thr Phe Pro Pro Thr Leu Tyr 
                405                 410                 415     


Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Leu Val Pro Lys Ala 
            420                 425                 430         


Ala Leu Leu Leu Arg Ala Arg Arg Ala Pro Lys Ser Ser Leu Lys Phe 
        435                 440                 445             


Ser Pro Gly Pro Cys Pro Gly Pro Gly Pro Gly Pro Ser Pro Gly Pro 
    450                 455                 460                 


Gly Pro Gly Pro Ser Pro Gly Pro Gly Pro Gly Pro Ser Pro Cys Pro 
465                 470                 475                 480 


Gly Pro Ser Pro Ser Pro Gln 
                485         


<210>  5710
<211>  2599
<212>  DNA
<213>  Homosapiens

<400>  5710
gctcccggcg agcgggcgga gagcgggggc cgcactgggg agtgtgggct gggccgcaga     60

tgtcatgtgg cctgtgtttt ggaccgtggt tcgtacctat gctccttatg tcacattccc    120

tgttgccttc gtggtcgggg ctgtgggtta ccacctggaa tggttcatca ggggaaagga    180

cccccagccc gtggaggagg aaaagagcat ctcagagcgc cgggaggatc gcaagctgga    240

tgagcttcta ggcaaggacc acacgcaggt ggctggaatg aggctgtgag gctccagcag    300

ccgttttgtg ccacgaggca gtagaaacct gggttcctga tgactgtgga gctgccgaac    360

taatctggac ctccagattc catacctgca agacacatga acatctgtct tatccatccc    420

tggagaggat ccctggagag gagcaaaccc aggccatccg gattttctgc atgggagacc    480

tggctgaccg ctgcctgggc tgctttcaag tctcaccgaa ttatgaagtc aactactggg    540

tgtttagaat gtctcaagtt caaagactag caggctagaa gcagacatct gagagaactt    600

cgggcacctt agcaggagga atattaagat gtggcatgct gggcttatcg ggagactgga    660

tagggatcag aaggaataca tttctattct gcgagctgca gagctcagga gtcgttctga    720

tatcaggccc attgctgact ctgctaggaa atgtggaaag ctgcagctgc agacagctgg    780

ctgtgcctgc ttcactggag ttctcagctc tcttacacct gtctgtttag aaaggagcag    840

acaggctgtg aagctctgca ggattctttt cagtgctggg gcagaaggag aaatggtggg    900

gacagccact ctgggcatca gaaccgaata cctgctcccc actcctctca gttgcacagc    960

ccagctcctg gcttcactgc agtgggaagg gagatgaagg actcttgaac tcagaatatg   1020

actgaccaag acccttacag ctggggtgga ggtagggggc tgaaggcagg ttctggaggt   1080

ggagattgag tcttccagtt gttttcctgg caacagcggg aacaatagat tctaggttct   1140

ggctggctca ggagttgggg tgtctgacct gtctttcctc agtcccttct gctatagata   1200

ctgatagtcc tctgccacca ggctctgcct accaagtccc tgagctcttc ctgacctagc   1260

ctggctctga gaggggagcc agcatggcag agggtgggcc tggtaccagt tgtgtctccc   1320

tgaatacagg atctgagagc tggggagcta tggacaccca gagcccatca gcctggtctc   1380

tcccctcact gtaggttccc aggccagtgg ctggttcctg attttaccta gtcttctgca   1440

ctgggataag aacctgacat ccagcttccc ctttgggagt aaggcctctt ccacgggctg   1500

ctcctggtct gtgttttcca ctgcagtctg ggagcctact tcccccatga aggccctaac   1560

cccacccatg aagacactac atgaattact gtccagactg gactccagat gcagcctcgg   1620

attagaccca atttggcctc atctccttgg agctgtctag taatttggaa tacacgctgc   1680

tccctactta gccacctgca aagcagggtc catctcccag cctggttctg ccttttcctc   1740

agtcttatat gtgtgtgtct gagtacatgt gtcagtcagt gatcatgcca ggacggccag   1800

ctggacttgt gtcagcatgc acatatgttc cttgaggctg tcccgtgcag gcgtgcactg   1860

agttctcagc ccagttctga agcgtgtttg tgaatatgcc cagatacatc atgaacattg   1920

ctgggatgct aggaggggga tcagtatgaa tgacattgca tgtcctcaag tacacaggta   1980

tgtgtctacg cacacgcaca aacctctcta atatgtatgt atgcacgtgt acatgtgtat   2040

aatatggcta agtgtgtgtc tgggagtatt tgaccatgtc tgatgtgaat cttctgccca   2100

ttctgaaagg aaaggggaca tgggcccact ctcccttttt gtagttacac tgtggtcagg   2160

gctggcttgt gacagaggga gtcaaggtga gtgcccctct gaacttctgg gatctttctg   2220

cctaacattc tgagacttcc ccagctgttc cctagtcctg cagccttggc tgtcagtact   2280

tcaagattat ctggccaggc gtggtggctc atgcctgtaa tcccagcatt ttgggaggcc   2340

gaggcgggca gatcatttga agtcaggagt ttgagaccag gccaacatgg tgagacccca   2400

tctctactaa aaataaaaaa attagccagg tgtactggca cgtgcctgta atcccagcta   2460

cttgggaggc tgaggcagga gaatcacttg aatccaggag acagaggctg aagtgagtcg   2520

agattgcacc actgcactcc agcctgggtg acagagtgac acttggtctc aaaaacaaac   2580

gaacaaacaa caaacaaac                                                2599


<210>  5711
<211>  122
<212>  PRT
<213>  Homosapiens

<400>  5711

Met Trp His Ala Gly Leu Ile Gly Arg Leu Asp Arg Asp Gln Lys Glu 
1               5                   10                  15      


Tyr Ile Ser Ile Leu Arg Ala Ala Glu Leu Arg Ser Arg Ser Asp Ile 
            20                  25                  30          


Arg Pro Ile Ala Asp Ser Ala Arg Lys Cys Gly Lys Leu Gln Leu Gln 
        35                  40                  45              


Thr Ala Gly Cys Ala Cys Phe Thr Gly Val Leu Ser Ser Leu Thr Pro 
    50                  55                  60                  


Val Cys Leu Glu Arg Ser Arg Gln Ala Val Lys Leu Cys Arg Ile Leu 
65                  70                  75                  80  


Phe Ser Ala Gly Ala Glu Gly Glu Met Val Gly Thr Ala Thr Leu Gly 
                85                  90                  95      


Ile Arg Thr Glu Tyr Leu Leu Pro Thr Pro Leu Ser Cys Thr Ala Gln 
            100                 105                 110         


Leu Leu Ala Ser Leu Gln Trp Glu Gly Arg 
        115                 120         


<210>  5712
<211>  599
<212>  DNA
<213>  Homosapiens

<400>  5712
ataagtttat cctggacaat ttccatattg ctggacattt gaattgtttc tggttggtca     60

ctcgtttaga tactgcaacg aatatcttat atgaagcttt tcctgcgttt tggaataaac    120

agtaaaaata gtaaatgtca ttttggatga aatgggataa atgagcagtt ttgaggatct    180

catgcataac accaaatgtc tttccaaaag ggctctagga gtttctacta aatcttacca    240

ctgaagacgt tgctggtaag gctgtgaggg gagtaaaagc agagagcagg aagaagcata    300

agaagctgtt gcctcttgaa gcctactgat gtttaactaa agtcagcaca gggcagtagt    360

gagcatttga tgaattgatc tgcagttttc ctaagcacag attgtctttc ctgctctgct    420

tctctagccc tgtgttcatt cttccactgc aagaatgttg ttaaataagg cactgggatt    480

ggtgtgtctg tatccccccc tagactgtga gttccttgag ggcagggacc aattcttact    540

cctctgcccc ttgcagagta cctcacaaat gatcattgtc aataaatgtt gaatgaatt     599


<210>  5713
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  5713

Met Leu Leu Asn Lys Ala Leu Gly Leu Val Cys Leu Tyr Pro Pro Leu 
1               5                   10                  15      


Asp Cys Glu Phe Leu Glu Gly Arg Asp Gln Phe Leu Leu Leu Cys Pro 
            20                  25                  30          


Leu Gln Ser Thr Ser Gln Met Ile Ile Val Asn Lys Cys 
        35                  40                  45  


<210>  5714
<211>  1775
<212>  DNA
<213>  Homosapiens

<400>  5714
cggttttctt ccatgcttgc tgattcacct tggaggcatg tgaccctctt tttgactggc     60

cttccagtca cagttcactg aaacacatga gtgagtggat gtgcttgggg ctttttgctc    120

cccgcttacc cccgtctctt cccagcccaa tgatggtggt ggctttagta tagggtcctc    180

tccgagcacg gcaggaatca cttctctccc tgcagcggtt cagtgtctgg tgcttttcca    240

ctctttctag actctttcct gtgcctgttg ctgtgttagc acaagtcggc tgggcagctg    300

ccagaacaag cctgccaggg agccttttga ctctggtcag ctccccaggg ctccaggctg    360

gtgggactgc cgctgagtga aacatcatgg aattagcctt gccagagtct gggttgggag    420

ccaggcagtg aaaatgtaaa agcccctccg tcttgctcac ttttcctttt ctactttgct    480

ttagatctct aagcacttgt agggtaggga gccagggcag tgtagcagag gaaaaataaa    540

gtggattcta gagtctgaca ggctcgagtt atgaatactg ccttaacaat taactggatg    600

accttgggca agtcacttag cccttctgaa cctcaatatc ctcacaacaa ccagtaggta    660

ctcagtaaat gttagcagct ttaattgtat tgcaggaaga acctatgttt cctgcaatag    720

ttgtgtgtat ccttgtgacc ctggtgaggt ggggatctag gggagagagc agccttggct    780

gagggacaac agggaccctc atagacctgg tggttgaggg ctgcttagaa atatttcaca    840

gagagaactg gcttgcataa gaaccaagaa gcacaagctg gtcaggagat tgcaggctcc    900

acacctgcct tagtggtagt tccatcagtg cagtctgcaa agtcagaggg aagcagattg    960

gccagaatgc ccaggaggtc acagatcagg agaattggga ggggaaagag ccttggactt   1020

ggaggcaagc gatctgagtg atgacctggg gtatgccgct tcacctctac tggccttggt   1080

ttccctgcaa aatggggaac gtgttccctg ctgatcgtgt gaaaagagtg agacaaccag   1140

tttagagtgc tctgaaaaca tgcaagtgct agatattaca gcccagtaaa acctccttta   1200

tctagttggg atggcagcca gtctgaataa taaaatacaa atacatgtgc tattatttct   1260

ttcctgtaca gagcgtattt tatagtattt gctaagtaga agtctttagg ggaatcagtt   1320

tgaagagtga agagtaatta gtaaccggtg tatcagtttt catcctgttc cagcagtgcc   1380

tctggtactt aaaaaacagt ttattctttt tgaattaaac ttgttaacat caattatgtg   1440

ttaatcagat cctttttaca taatacaaaa gtaaactctg gctttgtttt ttgttaaaaa   1500

atgcctaatg ggcccttcta attattcaga tttaaaaaaa tctttactag cgccccagca   1560

agggcacctt ttccatgtag aagaatccaa agtccttagg gcccttattc cctctctcac   1620

tgcccagttt cttcacttcc aacccctgct gcaattccgt ttctccttct ctgagcctaa   1680

gctgctaagt gcagctggag taatttgcat aaccatctcg cccggccctc ttccttcatg   1740

ggttgtggat gcaacagagt ctgcaacact tcaag                              1775


<210>  5715
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  5715

Met Gly Pro Ser Asn Tyr Ser Asp Leu Lys Lys Ser Leu Leu Ala Pro 
1               5                   10                  15      


Gln Gln Gly His Leu Phe His Val Glu Glu Ser Lys Val Leu Arg Ala 
            20                  25                  30          


Leu Ile Pro Ser Leu Thr Ala Gln Phe Leu His Phe Gln Pro Leu Leu 
        35                  40                  45              


Gln Phe Arg Phe Ser Phe Ser Glu Pro Lys Leu Leu Ser Ala Ala Gly 
    50                  55                  60                  


Val Ile Cys Ile Thr Ile Ser Pro Gly Pro Leu Pro Ser Trp Val Val 
65                  70                  75                  80  


Asp Ala Thr Glu Ser Ala Thr Leu 
                85              


<210>  5716
<211>  2592
<212>  DNA
<213>  Homosapiens

<400>  5716
ctgcgctccg agagagccgg cggccagtgg gcagggtcac agggcaaggt cccgcgggcc     60

gctgggtgcg gcgacttccg tgctcccggc gagcgggcgg agagcggggg ccgcactggg    120

gagtgtgggc tgggccgcag atgtcatgtg gcctgtgttt tggaccgtgg ttcgtaccta    180

tgctccttat gtcacattcc ctgttgcctt cgtggtcggg gctgtgggtt accacctgga    240

atggttcatc aggggaaagg acccccagcc cgtggaggag gaaaagagca tctcagagcg    300

ccgggaggat cgcaagctgg atgagcttct aggcaaggac cacacgcagg tggtgagcct    360

taaggacaag ctagaatttg ccccgaaagc tgtgctgaac agaaaccgcc cagagaagaa    420

ttaatggagg acacagggcc ctatggtcct actgtgggtg gtgacttgtc ctgctaccat    480

gttgacagag ccccagaacc cacatctaat tggctttgtt gcttattctg gcccttccca    540

caccacacag ccacacaaat actggctgct ccttgatggc caggcagacc cagcagcagc    600

cgaggggcca gtgaagagga aggccgcatc tgttgtgtgg tggccacaag cactcaggca    660

tctgagttta ctggtgcact gctgggagga gagttatgag atgaacattg gctgtcaatc    720

tctgtgggca ggcggtttgg cctctagtgg gaatggctgg gatttgggcg ttgcctttag    780

gagggatacc tgcatgtcta gttccagtct gcactggaaa gaattcaaat atgcacctgg    840

ctcccttcac tattttgccc tatcctttgt gctcattctt actgaaatct gtcttgtcag    900

ctcaggaatg ggattccccc aggaaggaaa gcacttttct gttctgggaa gcccagactg    960

ttcactttgg ggcagggacg aacatgtgcc tcgtgaattt gcttgaaaac agtcaccatc   1020

ttctaccccc atcactgtat agtgaaaaac ctgattaaag tggtatctga gaaccataat   1080

gatcgaatct tatcatccag gtggtatttg ggggtcttct taggagttag gcaagtacag   1140

gcattttaga gcaggataac attggtatta aagggtgcca aggagccctg gaaactgctt   1200

tactagtgcg gttgcactga accctggagg cacagattcc caggaacctt tttaccatta   1260

ttacaattgg ctgcagcacc ttcaagtcta aatggaggta gacctcacat acacacacat   1320

agacgccttt ccctataaaa gtatatacgc acattcaaga aaatttggta gggattttaa   1380

aaaggtcacc catgttccca gctcgttaat aacaaccgtt aacattttgt tgtcttttac   1440

taattctctg cataggtttt agagatagtt atcattactg tacatttaat tttatatact   1500

tttctcacta ttatcatttt cccattttac atggtcatca taattggttt tttggagaca   1560

gggtctcact ctgtcacaca ggctggagtg cagtacaatt acggctcagt gcaaccttga   1620

cctcctgggc tcaagtgatc ctctcacttc agctcctcaa gtagatggga ctacaggagt   1680

atgccaccat gcccagctaa tttttttatt tttttgtaga accaggtctc actatgttgc   1740

ccaggctagt ctcaaactcc tgggctcaag tgatcctccg gccttggcct gtagtttctt   1800

ttttcttttt ttttggagat ggactctcat tctgtcaccc gggctggagt gcagtggcgt   1860

gatcttggct gactgcaact tctgcctcct gggttcaagc gattctccta cctcagcttc   1920

ctaagtagct gggattacag gcgtgcgcca tcgtgcctgg ctagtttttg tgtttttagt   1980

aaagacaggg gtttcaccat cttggccagg ctggtctcga actcctgacc tcaagcgatc   2040

ccatctgcct cggcctccca aagtgctggg attacaggtg tgaggcaccg tgcctggcag   2100

tctgtagttt ttttttgttg ttgttgttgt tgttgtttta aatatggagt ctcgctgtat   2160

tgcccaggct ggagtgcagt ggcgcgatct tggttcactg caacctccac ctcttgggtt   2220

caagcgattc tcctgcctca gcctcctgag tagctgggat tacaggtgtg cgccgctacg   2280

cctggctaat ttttgtattt ttagtagaga cagggtttca ccatgttggt caggctggtc   2340

tcaaacttct gaccttgtga tctgcctgcc ttggcctcct aaagtgctgg gattacaggc   2400

gtgagccacc gtgcctggct gtagttgttt ataatagcaa cataattgtc tatcaagtgg   2460

gagtatgaca taagtttatc ctggacaatt tccatattgc tggacatttg aattgtttct   2520

ggttggtcac tcgtttagat actgcaacga atatcttata tgaagctttt cctgcgtttt   2580

ggaataaaca gt                                                       2592


<210>  5717
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  5717

Met Ser Cys Gly Leu Cys Phe Gly Pro Trp Phe Val Pro Met Leu Leu 
1               5                   10                  15      


Met Ser His Ser Leu Leu Pro Ser Trp Ser Gly Leu Trp Val Thr Thr 
            20                  25                  30          


Trp Asn Gly Ser Ser Gly Glu Arg Thr Pro Ser Pro Trp Arg Arg Lys 
        35                  40                  45              


Arg Ala Ser Gln Ser Ala Gly Arg Ile Ala Ser Trp Met Ser Phe 
    50                  55                  60              


<210>  5718
<211>  1834
<212>  DNA
<213>  Homosapiens

<400>  5718
gcgggggccg cactggggag tgtgggctgg gccgcaggtg agcgcgcggt cccggcgagc     60

aggtcgggtc agcccaggcc agtaacctct gagttacggg aggagtgatc gctagggtcc    120

accccggtcc cggccagatc tgccagctcc cctctctggc gggtgttctg gtgccaagtc    180

tgggagccca ggtagccctc cgcagacagg gcttctcggc acctcaatga ggacggacgt    240

tgatgaggcc atgaatgaga tgtcatgtgg cctgtgtttt ggaccgtggt tcgtacctat    300

gctccttatg tcacattccc tgttgccttc gtggtcgggg ctgtgggtta ccacctggaa    360

tggttcatca ggggaaagga cccccagccc gtggaggagg aaaagagcat ctcagagcgc    420

cgggaggatc gcaagctgga tgagcttcta ggcaaggacc acacgcaggt ggtgagcctt    480

aaggacaagc tagaatttgc cccgaaagct gtgctgaaca gaaaccgccc agagaagaat    540

taatggagga cacagggccc tatggtccta ctgtgggtgg tgacttgtcc tgctaccatg    600

ttgacagagc cccagaaccc acatctaatt ggctttgttg cttattctgg cccttcccac    660

accacacagc cacacaaata ctggctgctc cttgatggcc aggcagaccc agcagcagcc    720

gaggggccag tgaagaggaa ggccgcatct gttgtgtggt ggccacaagc actcaggcat    780

ctgagtttac tggtgcactg ctgggaggag agttatgaga tgaacattgg ctgtcaatct    840

ctgtgggcag gcggtttggc ctctagtggg aatggctggg atttgggcgt tgcctttagg    900

agggatacct gcatgtctag ttccagtctg cactggaaag aattcaaata tgcacctggc    960

tcccttcact attttgccct atcctttgtg ctcattctta ctgaaatctg tcttgtcagc   1020

tcaggaatgg gattccccca ggaaggaaag cacttttctg ttctgggaag cccagactgt   1080

tcactttggg gcagggacga acatgtgcct cgtgaatttg cttgaaaaca gtcaccatct   1140

tctaccccca tcactgtata gtgaaaaacc tgattaaagt ggtatctgag aaccataatg   1200

atcgaatctt atcatccagg tggtatttgg gggtcttctt aggagttagg caagtacagg   1260

cattttagag caggataaca ttggtattaa agggtgccaa ggagccctgg aaactgcttt   1320

actagtgcgg ttgcactgaa ccctggaggc acagattccc aggaaccttt ttaccattat   1380

tacaattggc tgcagcacct tcaagtctaa atggaggtag acctcacata cacacacata   1440

gacgcctttc cctataaaag tatatacgca cattcaagaa aatttggtag ggattttaaa   1500

aaggtcaccc atgttcccag ctcgttaata acaaccgtta acattttgtt gtcttttact   1560

aattctctgc ataggtttta gagatagtta tcattactgt acatttaatt ttatatactt   1620

ttctcactat tatcattttc ccattttaca tggtcatcat aattggtttt ttggagacag   1680

ggtctcactc tgtcacacag gctggagtgc agtacaatta cggctcagtg caaccttgac   1740

ctcctgggct caagtgatcc tctcacttca gctcctcaag tagatgggac tacaggagta   1800

tgccaccatg cccagctaat ttttttattt tttt                               1834


<210>  5719
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  5719

Met Arg Thr Asp Val Asp Glu Ala Met Asn Glu Met Ser Cys Gly Leu 
1               5                   10                  15      


Cys Phe Gly Pro Trp Phe Val Pro Met Leu Leu Met Ser His Ser Leu 
            20                  25                  30          


Leu Pro Ser Trp Ser Gly Leu Trp Val Thr Thr Trp Asn Gly Ser Ser 
        35                  40                  45              


Gly Glu Arg Thr Pro Ser Pro Trp Arg Arg Lys Arg Ala Ser Gln Ser 
    50                  55                  60                  


Ala Gly Arg Ile Ala Ser Trp Met Ser Phe 
65                  70                  


<210>  5720
<211>  2662
<212>  DNA
<213>  Homosapiens

<400>  5720
cttccgtgct cccggcgagc gggcggagag cgggggccgc actggggagt gtgggctggg     60

ccgcaggtga gcgcgcggtc ccggcgagca ggtcgggtca gcccaggcca gtaacctctg    120

agttacggga ggagtgatcg ctagggtcca ccccggtccc ggccagatct gccagctccc    180

ctctctggcg ggtgttctgg tgccaagtct gggagcccag gtagccctcc gcagacaggg    240

cttctcggca cctcaatgag gacggacgtt gatgaggcca tgaatgaggt gggctaggga    300

caggggaccg ggagactcac agaagggaga agggtagcca tttggatgga ccttcgcctt    360

acttgcgctc ccattcctgg actgcgctct agtgactgtc agggctaatt cttccgcctt    420

ctcaggcctc ctgtgtcctt gttagtagtt cttgaatttg ggactacggc ttctggcctc    480

gttgggcctc cgggccctcg cactggggca ggtttcccag cagcccagtt gacctttacc    540

ggatgctttt ggcagacgtc ctccatgccg ggctggaaat atgcgtcaca gtgtttttca    600

gacacttttg cctctttcat tgtgataccc tgcctgggga cgactatgat ggagtcttta    660

ggtttttgta atcagcaaag gcatctgtta tgctcctgcc accttttggg ggagagtggg    720

tggaggatgt tgtgatttta cactagggag tttgggctgt cattcattcg ttcagcagac    780

cttttttggg cactctgcca ggcagggtag gagaggtgcc tggatggata gggcataatt    840

gggccagaca gacacggttc ttagcctttt ggagcttaaa gtgtcttgag aaacgcagac    900

agggaaaagg aacgactttt catattgtga aaccaggaga ttcatcgtag attgtgtttc    960

atggggaaaa ggtggccggc tgtgctcatg gagaaatttc atagagcaga gaaaggcatc   1020

tttttccctt cttgaaatgt tggcagacta ggtcctgggg tcaacaatag gcttgaagct   1080

ctattagatg tcatgtggcc tgtgttttgg accgtggttc gtacctatgc tccttatgtc   1140

acattccctg ttgccttcgt ggtcggggct gtgggttacc acctggaatg gttcatcagg   1200

ggaaaggacc cccagcccgt ggaggaggaa aagagcatct cagagcgccg ggaggatcgc   1260

aagctggatg agcttctagg caaggaccac acgcaggtgg tgagccttaa ggacaagcta   1320

gaatttgccc cgaaagctgt gctgaacaga aaccgcccag agaagaatta atggaggaca   1380

cagggcccta tggtcctact gtgggtggtg acttgtcctg ctaccatgtt gacagagccc   1440

cagaacccac atctaattgg ctttgttgct tattctggcc cttcccacac cacacagcca   1500

cacaaatact ggctgctcct tgatggccag gcagacccag cagcagccga ggggccagtg   1560

aagaggaagg ccgcatctgt tgtgtggtgg ccacaagcac tcaggcatct gagtttactg   1620

gtgcactgct gggaggagag ttatgagatg aacattggct gtcaatctct gtgggcaggc   1680

ggtttggcct ctagtgggaa tggctgggat ttgggcgttg cctttaggag ggatacctgc   1740

atgtctagtt ccagtctgca ctggaaagaa ttcaaatatg cacctggctc ccttcactat   1800

tttgccctat cctttgtgct cattcttact gaaatctgtc ttgtcagctc aggaatggga   1860

ttcccccagg aaggaaagca cttttctgtt ctgggaagcc cagactgttc actttggggc   1920

agggacgaac atgtgcctcg tgaatttgct tgaaaacagt caccatcttc tacccccatc   1980

actgtatagt gaaaaacctg attaaagtgg tatctgagaa ccataatgat cgaatcttat   2040

catccaggtg gtatttgggg gtcttcttag gagttaggca agtacaggca ttttagagca   2100

ggataacatt ggtattaaag ggtgccaagg agccctggaa actgctttac tagtgcggtt   2160

gcactgaacc ctggaggcac agattcccag gaaccttttt accattatta caattggctg   2220

cagcaccttc aagtctaaat ggaggtagac ctcacataca cacacataga cgcctttccc   2280

tataaaagta tatacgcaca ttcaagaaaa tttggtaggg attttaaaaa ggtcacccat   2340

gttcccagct cgttaataac aaccgttaac attttgttgt cttttactaa ttctctgcat   2400

aggttttaga gatagttatc attactgtac atttaatttt atatactttt ctcactatta   2460

tcattttccc attttacatg gtcatcataa ttggtttttt ggagacaggg tctcactctg   2520

tcacacaggc tggagtgcag tacaattacg gctcagtgca accttgacct cctgggctca   2580

agtgatcctc tcacttcagc tcctcaagta gatgggacta caggagtatg ccaccatgcc   2640

cagctaattt ttttattttt tt                                            2662


<210>  5721
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  5721

Met Ser Cys Gly Leu Cys Phe Gly Pro Trp Phe Val Pro Met Leu Leu 
1               5                   10                  15      


Met Ser His Ser Leu Leu Pro Ser Trp Ser Gly Leu Trp Val Thr Thr 
            20                  25                  30          


Trp Asn Gly Ser Ser Gly Glu Arg Thr Pro Ser Pro Trp Arg Arg Lys 
        35                  40                  45              


Arg Ala Ser Gln Ser Ala Gly Arg Ile Ala Ser Trp Met Ser Phe 
    50                  55                  60              


<210>  5722
<211>  1563
<212>  DNA
<213>  Homosapiens

<400>  5722
ccgcgggccg ctgggtgcgg cgacttccgt gctcccggcg agcgggcgga gagcgggggc     60

cgcactgggg agtgtgggct gggccgcaga tgtcatgtgg cctgtgtttt ggaccgtggt    120

tcgtacctat gctccttatg tcacattccc tgttgccttc gtggtcgggg ctgtgggtta    180

ccacctggaa tggttcatca ggggaaagga cccccagccc gtggaggagg aaaagagcat    240

ctcagagcgc cgggaggatc gcaagctgga tgagcttcta ggcaaggacc acacgcaggt    300

ggtgagcctt aaggacaagc tagaatttgc cccgaaagct gtgctgaaca gaaaccgccc    360

agagaagaat taatggagga cacagggccc tatggtccta ctgtgggtgg tgacttgtcc    420

tgctaccatg ttgacagagc cccagaaccc acatctaatt ggctttgttg cttattctgg    480

cccttcccac accacacaca ctcaggcatc tgagtttact ggtgcactgc tgggaggaga    540

gttatgagat gaacattggc tgtcaatctc tgtgggcagg cggtttggcc tctagtggga    600

atggctggga tttgggcgtt gcctttagga gggatacctg catgtctagt tccagtctgc    660

actggaaaga attcaaatat gcacctggct cccttcacta ttttgcccta tcctttgtgc    720

tcattcttac tgaaatctgt cttgtcagct caggaatggg attcccccag gaaggaaagc    780

acttttctgt tctgggaagc ccagactgtt cactttgggg cagggacgaa catgtgcctc    840

gtgaatttgc ttgaaaacag tcaccatctt ctacccccat cactgtatag tgaaaaacct    900

gattaaagtg gtatctgaga accataatga tcgaatctta tcatccaggt ggtatttggg    960

ggtcttctta ggagttaggc aagtacaggc attttagagc aggataacat tggtattaaa   1020

gggtgccaag gagccctgga aactgcttta ctagtgcggt tgcactgaac cctggaggca   1080

cagattccca ggaacctttt taccattatt acaattggct gcagcacctt caagtctaaa   1140

tggaggtaga cctcacatac acacacatag acgcctttcc ctataaaagt atatacgcac   1200

attcaagaaa atttggtagg gattttaaaa aggtcaccca tgttcccagc tcgttaataa   1260

caaccgttaa cattttgttg tcttttacta attctctgca taggttttag agatagttat   1320

cattactgta catttaattt tatatacttt tctcactatt atcattttcc cattttacat   1380

ggtcatcata attggttttt tggagacagg gtctcactct gtcacacagg ctggagtgca   1440

gtacaattac ggctcagtgc aaccttgacc tcctgggctc aagtgatcct ctcacttcag   1500

ctcctcaagt agatgggact acaggagtat gccaccatgc ccagctaatt tttttatttt   1560

ttt                                                                 1563


<210>  5723
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  5723

Met Ser Cys Gly Leu Cys Phe Gly Pro Trp Phe Val Pro Met Leu Leu 
1               5                   10                  15      


Met Ser His Ser Leu Leu Pro Ser Trp Ser Gly Leu Trp Val Thr Thr 
            20                  25                  30          


Trp Asn Gly Ser Ser Gly Glu Arg Thr Pro Ser Pro Trp Arg Arg Lys 
        35                  40                  45              


Arg Ala Ser Gln Ser Ala Gly Arg Ile Ala Ser Trp Met Ser Phe 
    50                  55                  60              


<210>  5724
<211>  2550
<212>  DNA
<213>  Homosapiens

<400>  5724
ggcagggtca cagggcaagg tcccgcgggc cgctgggtgc ggcgacttcc gtgctcccgg     60

cgagcgggcg gagagcgggg gccgcactgg ggagtgtggg ctgggccgca ggtgagcgcg    120

cggtcccggc gagcaggtcg ggtcagccca ggccagtaac ctctgagtta cgggaggagt    180

gatcgctagg gtccaccccg gtcccggcca gatctgccag ctcccctctc tggcgggtgt    240

tctggtgcca agtctgggag cccaggtagc cctccgcaga cagggcttct cggcacctca    300

atgaggacgg acgttgatga ggccatgaat gaggtgggct agggacaggg gaccgggaga    360

ctcacagaag ggagaagggt agccatttgg atggaccttc gccttacttg cgctcccatt    420

cctggactgc gctctagtga ctgtcagggc taattcttcc gccttctcag gcctcctgtg    480

tccttgttag tagttcttga atttgggact acggcttctg gcctcgttgg gcctccgggc    540

cctcgcactg gggcaggttt cccagcagcc cagttgacct ttaccggatg cttttggcag    600

acgtcctcca tgccgggctg gaaatatgcg tcacagtgtt tttcagacac ttttgcctct    660

ttcattgtga taccctgcct ggggacgact atgatggagt ctttaggttt ttgtaatcag    720

caaaggcatc tgttatgctc ctgccacctt ttgggggaga gtgggtggag gatgttgtga    780

ttttacacta gggagtttgg gctgtcattc attcgttcag cagacctttt ttgggcactc    840

tgccaggcag ggtaggagag gtgcctggat ggatagggca taattgggcc agacagacac    900

ggttcttagc cttttggagc ttaaagtgtc ttgagaaacg cagacagggt aagccagcat    960

cgtgcctgac acagaatgtc atgtggcctg tgttttggac cgtggttcgt acctatgctc   1020

cttatgtcac attccctgtt gccttcgtgg tcggggctgt gggttaccac ctggaatggt   1080

tcatcagggg aaaggacccc cagcccgtgg aggaggaaaa gagcatctca gagcgccggg   1140

aggatcgcaa gctggatgag cttctaggca aggaccacac gcaggtggtg agccttaagg   1200

acaagctaga atttgccccg aaagctgtgc tgaacagaaa ccgcccagag aagaattaat   1260

ggaggacaca gggccctatg gtcctactgt gggtggtgac ttgtcctgct accatgttga   1320

cagagcccca gaacccacat ctaattggct ttgttgctta ttctggccct tcccacacca   1380

cacagccaca caaatactgg ctgctccttg atggccaggc agacccagca gcagccgagg   1440

ggccagtgaa gaggaaggcc gcatctgttg tgtggtggcc acaagcactc aggcatctga   1500

gtttactggt gcactgctgg gaggagagtt atgagatgaa cattggctgt caatctctgt   1560

gggcaggcgg tttggcctct agtgggaatg gctgggattt gggcgttgcc tttaggaggg   1620

atacctgcat gtctagttcc agtctgcact ggaaagaatt caaatatgca cctggctccc   1680

ttcactattt tgccctatcc tttgtgctca ttcttactga aatctgtctt gtcagctcag   1740

gaatgggatt cccccaggaa ggaaagcact tttctgttct gggaagccca gactgttcac   1800

tttggggcag ggacgaacat gtgcctcgtg aatttgcttg aaaacagtca ccatcttcta   1860

cccccatcac tgtatagtga aaaacctgat taaagtggta tctgagaacc ataatgatcg   1920

aatcttatca tccaggtggt atttgggggt cttcttagga gttaggcaag tacaggcatt   1980

ttagagcagg ataacattgg tattaaaggg tgccaaggag ccctggaaac tgctttacta   2040

gtgcggttgc actgaaccct ggaggcacag attcccagga acctttttac cattattaca   2100

attggctgca gcaccttcaa gtctaaatgg aggtagacct cacatacaca cacatagacg   2160

cctttcccta taaaagtata tacgcacatt caagaaaatt tggtagggat tttaaaaagg   2220

tcacccatgt tcccagctcg ttaataacaa ccgttaacat tttgttgtct tttactaatt   2280

ctctgcatag gttttagaga tagttatcat tactgtacat ttaattttat atacttttct   2340

cactattatc attttcccat tttacatggt catcataatt ggttttttgg agacagggtc   2400

tcactctgtc acacaggctg gagtgcagta caattacggc tcagtgcaac cttgacctcc   2460

tgggctcaag tgatcctctc acttcagctc ctcaagtaga tgggactaca ggagtatgcc   2520

accatgccca gctaattttt ttattttttt                                    2550


<210>  5725
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  5725

Met Ser Cys Gly Leu Cys Phe Gly Pro Trp Phe Val Pro Met Leu Leu 
1               5                   10                  15      


Met Ser His Ser Leu Leu Pro Ser Trp Ser Gly Leu Trp Val Thr Thr 
            20                  25                  30          


Trp Asn Gly Ser Ser Gly Glu Arg Thr Pro Ser Pro Trp Arg Arg Lys 
        35                  40                  45              


Arg Ala Ser Gln Ser Ala Gly Arg Ile Ala Ser Trp Met Ser Phe 
    50                  55                  60              


<210>  5726
<211>  1204
<212>  DNA
<213>  Homosapiens

<400>  5726
gcgggggccg cactggggag tgtgggctgg gccgcaggtg agcgcgcggt cccggcgagc     60

aggtcgggtc agcccaggcc agtaacctct gagttacggg aggagtgatc gctagggtcc    120

accccggtcc cggccagatc tgccagctcc cctctctggc gggtgttctg gtgccaagtc    180

tgggagccca ggtagccctc cgcagacagg gcttctcggc acctcaatga ggacggacgt    240

tgatgaggcc atgaatgaga tgtcatgtgg cctgtgtttt ggaccgtggt tcgtacctat    300

gctccttatg tcacattccc tgttgccttc gtggtcgggg ctgtgggtta ccacctggaa    360

tggttcatca ggggaaagga cccccagccc gtggaggagg aaaagagcat ctcagagcgc    420

cgggaggatc gcaagctgga tgagcttcta ggcaaggacc acacgcaggt ggtgagcctt    480

aaggacaagc tagaatttgc cccgaaagct gtgctgaaca gaaaccgccc agagaagaat    540

taatggagga cacagggccc tatggtccta ctgtgggtgg tgacttgtcc tgctaccatg    600

ttgacagagc cccagaaccc acatctaatt ggctttgttg cttattctgg cccttcccac    660

accacacagc cacacaaata ctggctgctc cttgatggcc aggcagaccc agcagcagcc    720

gaggggccag tgaagaggaa ggccgcatct gttgtgtggt ggccacaagc actcaggcat    780

ctgagtttac tggtgcactg ctgggaggag agttatgaga tgaacattgg ctgtcaatct    840

ctgtgggcag gcggtttggc ctctagtggg aatggctggg atttgggcgt tgcctttagg    900

agggatacct gcatgtctag ttccagtctg cactggaaag aattcaaata tgcacctggc    960

tcccttcact attttgccct atcctttgtg ctcattctta ctgaaatctg tcttgtcagc   1020

tcaggaatgg gattccccca ggaaggaaag cacttttctg ttctgggaag cccagactgt   1080

tcactttggg gcagggacga acatgtgcct cgtgaatttg cttgaaaaca gtcaccatct   1140

tctaccccca tcactgtata gtgaaaaacc tgattaaagt ggtatctgag aaccataatg   1200

atcg                                                                1204


<210>  5727
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  5727

Met Arg Thr Asp Val Asp Glu Ala Met Asn Glu Met Ser Cys Gly Leu 
1               5                   10                  15      


Cys Phe Gly Pro Trp Phe Val Pro Met Leu Leu Met Ser His Ser Leu 
            20                  25                  30          


Leu Pro Ser Trp Ser Gly Leu Trp Val Thr Thr Trp Asn Gly Ser Ser 
        35                  40                  45              


Gly Glu Arg Thr Pro Ser Pro Trp Arg Arg Lys Arg Ala Ser Gln Ser 
    50                  55                  60                  


Ala Gly Arg Ile Ala Ser Trp Met Ser Phe 
65                  70                  


<210>  5728
<211>  2032
<212>  DNA
<213>  Homosapiens

<400>  5728
cttccgtgct cccggcgagc gggcggagag cgggggccgc actggggagt gtgggctggg     60

ccgcaggtga gcgcgcggtc ccggcgagca ggtcgggtca gcccaggcca gtaacctctg    120

agttacggga ggagtgatcg ctagggtcca ccccggtccc ggccagatct gccagctccc    180

ctctctggcg ggtgttctgg tgccaagtct gggagcccag gtagccctcc gcagacaggg    240

cttctcggca cctcaatgag gacggacgtt gatgaggcca tgaatgaggt gggctaggga    300

caggggaccg ggagactcac agaagggaga agggtagcca tttggatgga ccttcgcctt    360

acttgcgctc ccattcctgg actgcgctct agtgactgtc agggctaatt cttccgcctt    420

ctcaggcctc ctgtgtcctt gttagtagtt cttgaatttg ggactacggc ttctggcctc    480

gttgggcctc cgggccctcg cactggggca ggtttcccag cagcccagtt gacctttacc    540

ggatgctttt ggcagacgtc ctccatgccg ggctggaaat atgcgtcaca gtgtttttca    600

gacacttttg cctctttcat tgtgataccc tgcctgggga cgactatgat ggagtcttta    660

ggtttttgta atcagcaaag gcatctgtta tgctcctgcc accttttggg ggagagtggg    720

tggaggatgt tgtgatttta cactagggag tttgggctgt cattcattcg ttcagcagac    780

cttttttggg cactctgcca ggcagggtag gagaggtgcc tggatggata gggcataatt    840

gggccagaca gacacggttc ttagcctttt ggagcttaaa gtgtcttgag aaacgcagac    900

agggaaaagg aacgactttt catattgtga aaccaggaga ttcatcgtag attgtgtttc    960

atggggaaaa ggtggccggc tgtgctcatg gagaaatttc atagagcaga gaaaggcatc   1020

tttttccctt cttgaaatgt tggcagacta ggtcctgggg tcaacaatag gcttgaagct   1080

ctattagatg tcatgtggcc tgtgttttgg accgtggttc gtacctatgc tccttatgtc   1140

acattccctg ttgccttcgt ggtcggggct gtgggttacc acctggaatg gttcatcagg   1200

ggaaaggacc cccagcccgt ggaggaggaa aagagcatct cagagcgccg ggaggatcgc   1260

aagctggatg agcttctagg caaggaccac acgcaggtgg tgagccttaa ggacaagcta   1320

gaatttgccc cgaaagctgt gctgaacaga aaccgcccag agaagaatta atggaggaca   1380

cagggcccta tggtcctact gtgggtggtg acttgtcctg ctaccatgtt gacagagccc   1440

cagaacccac atctaattgg ctttgttgct tattctggcc cttcccacac cacacagcca   1500

cacaaatact ggctgctcct tgatggccag gcagacccag cagcagccga ggggccagtg   1560

aagaggaagg ccgcatctgt tgtgtggtgg ccacaagcac tcaggcatct gagtttactg   1620

gtgcactgct gggaggagag ttatgagatg aacattggct gtcaatctct gtgggcaggc   1680

ggtttggcct ctagtgggaa tggctgggat ttgggcgttg cctttaggag ggatacctgc   1740

atgtctagtt ccagtctgca ctggaaagaa ttcaaatatg cacctggctc ccttcactat   1800

tttgccctat cctttgtgct cattcttact gaaatctgtc ttgtcagctc aggaatggga   1860

ttcccccagg aaggaaagca cttttctgtt ctgggaagcc cagactgttc actttggggc   1920

agggacgaac atgtgcctcg tgaatttgct tgaaaacagt caccatcttc tacccccatc   1980

actgtatagt gaaaaacctg attaaagtgg tatctgagaa ccataatgat cg           2032


<210>  5729
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  5729

Met Ser Cys Gly Leu Cys Phe Gly Pro Trp Phe Val Pro Met Leu Leu 
1               5                   10                  15      


Met Ser His Ser Leu Leu Pro Ser Trp Ser Gly Leu Trp Val Thr Thr 
            20                  25                  30          


Trp Asn Gly Ser Ser Gly Glu Arg Thr Pro Ser Pro Trp Arg Arg Lys 
        35                  40                  45              


Arg Ala Ser Gln Ser Ala Gly Arg Ile Ala Ser Trp Met Ser Phe 
    50                  55                  60              


<210>  5730
<211>  3502
<212>  DNA
<213>  Homosapiens

<400>  5730
cttccgtgct cccggcgagc gggcggagag cgggggccgc actggggagt gtgggctggg     60

ccgcaggtga gcgcgcggtc ccggcgagca ggtcgggtca gcccaggcca gtaacctctg    120

agttacggga ggagtgatcg ctagggtcca ccccggtccc ggccagatct gccagctccc    180

ctctctggcg ggtgttctgg tgccaagtct gggagcccag gtagccctcc gcagacaggg    240

cttctcggca cctcaatgag gacggacgtt gatgaggcca tgaatgaggt gggctaggga    300

caggggaccg ggagactcac agaagggaga agggtagcca tttggatgga ccttcgcctt    360

acttgcgctc ccattcctgg actgcgctct agtgactgtc agggctaatt cttccgcctt    420

ctcaggcctc ctgtgtcctt gttagtagtt cttgaatttg ggactacggc ttctggcctc    480

gttgggcctc cgggccctcg cactggggca ggtttcccag cagcccagtt gacctttacc    540

ggatgctttt ggcagacgtc ctccatgccg ggctggaaat atgcgtcaca gtgtttttca    600

gacacttttg cctctttcat tgtgataccc tgcctgggga cgactatgat ggagtcttta    660

ggtttttgta atcagcaaag gcatctgtta tgctcctgcc accttttggg ggagagtggg    720

tggaggatgt tgtgatttta cactagggag tttgggctgt cattcattcg ttcagcagac    780

cttttttggg cactctgcca ggcagggtag gagaggtgcc tggatggata gggcataatt    840

gggccagaca gacacggttc ttagcctttt ggagcttaaa gtgtcttgag aaacgcagac    900

agggtaagcc agcatcgtgc ctgacacaga gtaagtggtt ataagtgtcg aataaaggaa    960

tgaattgact tatttgggaa tgattagaat gtgagcagga cggtagcgag agactttatg   1020

ctgcatgtga gagatagttg tgaactcatg cgcgatatgt tttaagacag gtttggaaat   1080

ctgaacggac agttgctatt tagggaagca tttacttata cagaggactt gctttaaagg   1140

tggaagtaaa atggagaagt attaggtttg ggattcttca gaggtgcctc ttttaactat   1200

tactatgtct ctgaatttca taaatccctg agtacaatct cagagtttgg gaaaaggaaa   1260

gctcttctag gtaatgaaat gccaggctga tgggaaaaaa ctgtaggaag ctctccctaa   1320

gtccagggtt tggacagaaa ccgtatacct ctgcagtgtg ttcttcccac tagaaagagt   1380

gtaggctttg aaattggaga ggcctgggtt caaaatcagt ggctctatca cttctagtga   1440

tcttggataa gttaacataa tgtctgtgag cctttgtggc cttcacaaga gtctgggcta   1500

ataattccta catcatagag gtgttatgag gatcaaatga tgattagtgt gtaaattgtc   1560

atcatagtgc ctggtgctga gacaataagc gggggagtct tggagatgct gcaatttttt   1620

tttttttttt aaatttcatg atgctgcctt attgcagggg tccttaaccc cctgggccac   1680

agaccagtgg tggtcttcag cccattagaa actgggctgc acagcaggag gtgagcggtg   1740

ggcaagctgg caagcattac cgcctgagct ccaccttctg atagatcagc agcggcatta   1800

gattctcaca ggagtgcaaa ctctattgtg aactgcgcat gtgagggatc tacgttgtgt   1860

gccccttatg agaatctaat gcctgatgat ctgagctgga acagtttcat cccgaaacca   1920

tccctctcca acccccatct gtggaaaaat tgtcttccac gaaactggtc cctggtgcca   1980

aatatagatt ggggaccgct gccttatagt gttacgtcta gagaacattg ggattccttc   2040

aaagagaatt ggaaccaaag agagaggggg agaatcatct tatccttggt gaggtttcga   2100

ttgttcactt tagatcagag atagtagtgt tggagaaata cctacagggg cataaacaga   2160

aagatctttt agtggatact tttgggcaag tctcttaacc ctctgatagt gggttatgta   2220

tctacctcac gtggtggaca tgaggattaa gagagtgagt gtatatgaag cacctagccc   2280

aaggcctggc atgtaagtgc tcaataaatg gtagctgtgt tattataact gtgaatgatc   2340

tttgataatt gataatggta ataatcattt gagatggaat tggccattag agtgatccaa   2400

tttgtgtgtt tttacattac tttggtattg ccctacttca attcaggagg ccctgaggcc   2460

attccactcc gctccccgcc ccaccccacc ccaccccacc ccccgggctt gtacagtgat   2520

ttttcacaga aaatcttcag gttctgcggt atccagaatg tcatgtggcc tgtgttttgg   2580

accgtggttc gtacctatgc tccttatgtc acattccctg ttgccttcgt ggtcggggct   2640

gtgggttacc acctggaatg gttcatcagg ggaaaggacc cccagcccgt ggaggaggaa   2700

aagagcatct cagagcgccg ggaggatcgc aagctggatg agcttctagg caaggaccac   2760

acgcaggtgg tgagccttaa ggacaagcta gaatttgccc cgaaagctgt gctgaacaga   2820

aaccgcccag agaagaatta atggaggaca cagggcccta tggtcctact gtgggtggtg   2880

acttgtcctg ctaccatgtt gacagagccc cagaacccac atctaattgg ctttgttgct   2940

tattctggcc cttcccacac cacacagcca cacaaatact ggctgctcct tgatggccag   3000

gcagacccag cagcagccga ggggccagtg aagaggaagg ccgcatctgt tgtgtggtgg   3060

ccacaagcac tcaggcatct gagtttactg gtgcactgct gggaggagag ttatgagatg   3120

aacattggct gtcaatctct gtgggcaggc ggtttggcct ctagtgggaa tggctgggat   3180

ttgggcgttg cctttaggag ggatacctgc atgtctagtt ccagtctgca ctggaaagaa   3240

ttcaaatatg cacctggctc ccttcactat tttgccctat cctttgtgct cattcttact   3300

gaaatctgtc ttgtcagctc aggaatggga ttcccccagg aaggaaagca cttttctgtt   3360

ctgggaagcc cagactgttc actttggggc agggacgaac atgtgcctcg tgaatttgct   3420

tgaaaacagt caccatcttc tacccccatc actgtatagt gaaaaacctg attaaagtgg   3480

tatctgagaa ccataatgat cg                                            3502


<210>  5731
<211>  155
<212>  PRT
<213>  Homosapiens

<400>  5731

Met Glu Leu Ala Ile Arg Val Ile Gln Phe Val Cys Phe Tyr Ile Thr 
1               5                   10                  15      


Leu Val Leu Pro Tyr Phe Asn Ser Gly Gly Pro Glu Ala Ile Pro Leu 
            20                  25                  30          


Arg Ser Pro Pro His Pro Thr Pro Pro His Pro Pro Gly Leu Tyr Ser 
        35                  40                  45              


Asp Phe Ser Gln Lys Ile Phe Arg Phe Cys Gly Ile Gln Asn Val Met 
    50                  55                  60                  


Trp Pro Val Phe Trp Thr Val Val Arg Thr Tyr Ala Pro Tyr Val Thr 
65                  70                  75                  80  


Phe Pro Val Ala Phe Val Val Gly Ala Val Gly Tyr His Leu Glu Trp 
                85                  90                  95      


Phe Ile Arg Gly Lys Asp Pro Gln Pro Val Glu Glu Glu Lys Ser Ile 
            100                 105                 110         


Ser Glu Arg Arg Glu Asp Arg Lys Leu Asp Glu Leu Leu Gly Lys Asp 
        115                 120                 125             


His Thr Gln Val Val Ser Leu Lys Asp Lys Leu Glu Phe Ala Pro Lys 
    130                 135                 140                 


Ala Val Leu Asn Arg Asn Arg Pro Glu Lys Asn 
145                 150                 155 


<210>  5732
<211>  933
<212>  DNA
<213>  Homosapiens

<400>  5732
ccgcgggccg ctgggtgcgg cgacttccgt gctcccggcg agcgggcgga gagcgggggc     60

cgcactgggg agtgtgggct gggccgcaga tgtcatgtgg cctgtgtttt ggaccgtggt    120

tcgtacctat gctccttatg tcacattccc tgttgccttc gtggtcgggg ctgtgggtta    180

ccacctggaa tggttcatca ggggaaagga cccccagccc gtggaggagg aaaagagcat    240

ctcagagcgc cgggaggatc gcaagctgga tgagcttcta ggcaaggacc acacgcaggt    300

ggtgagcctt aaggacaagc tagaatttgc cccgaaagct gtgctgaaca gaaaccgccc    360

agagaagaat taatggagga cacagggccc tatggtccta ctgtgggtgg tgacttgtcc    420

tgctaccatg ttgacagagc cccagaaccc acatctaatt ggctttgttg cttattctgg    480

cccttcccac accacacaca ctcaggcatc tgagtttact ggtgcactgc tgggaggaga    540

gttatgagat gaacattggc tgtcaatctc tgtgggcagg cggtttggcc tctagtggga    600

atggctggga tttgggcgtt gcctttagga gggatacctg catgtctagt tccagtctgc    660

actggaaaga attcaaatat gcacctggct cccttcacta ttttgcccta tcctttgtgc    720

tcattcttac tgaaatctgt cttgtcagct caggaatggg attcccccag gaaggaaagc    780

acttttctgt tctgggaagc ccagactgtt cactttgggg cagggacgaa catgtgcctc    840

gtgaatttgc ttgaaaacag tcaccatctt ctacccccat cactgtatag tgaaaaacct    900

gattaaagtg gtatctgaga accataatga tcg                                 933


<210>  5733
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  5733

Met Ser Cys Gly Leu Cys Phe Gly Pro Trp Phe Val Pro Met Leu Leu 
1               5                   10                  15      


Met Ser His Ser Leu Leu Pro Ser Trp Ser Gly Leu Trp Val Thr Thr 
            20                  25                  30          


Trp Asn Gly Ser Ser Gly Glu Arg Thr Pro Ser Pro Trp Arg Arg Lys 
        35                  40                  45              


Arg Ala Ser Gln Ser Ala Gly Arg Ile Ala Ser Trp Met Ser Phe 
    50                  55                  60              


<210>  5734
<211>  1920
<212>  DNA
<213>  Homosapiens

<400>  5734
ggcagggtca cagggcaagg tcccgcgggc cgctgggtgc ggcgacttcc gtgctcccgg     60

cgagcgggcg gagagcgggg gccgcactgg ggagtgtggg ctgggccgca ggtgagcgcg    120

cggtcccggc gagcaggtcg ggtcagccca ggccagtaac ctctgagtta cgggaggagt    180

gatcgctagg gtccaccccg gtcccggcca gatctgccag ctcccctctc tggcgggtgt    240

tctggtgcca agtctgggag cccaggtagc cctccgcaga cagggcttct cggcacctca    300

atgaggacgg acgttgatga ggccatgaat gaggtgggct agggacaggg gaccgggaga    360

ctcacagaag ggagaagggt agccatttgg atggaccttc gccttacttg cgctcccatt    420

cctggactgc gctctagtga ctgtcagggc taattcttcc gccttctcag gcctcctgtg    480

tccttgttag tagttcttga atttgggact acggcttctg gcctcgttgg gcctccgggc    540

cctcgcactg gggcaggttt cccagcagcc cagttgacct ttaccggatg cttttggcag    600

acgtcctcca tgccgggctg gaaatatgcg tcacagtgtt tttcagacac ttttgcctct    660

ttcattgtga taccctgcct ggggacgact atgatggagt ctttaggttt ttgtaatcag    720

caaaggcatc tgttatgctc ctgccacctt ttgggggaga gtgggtggag gatgttgtga    780

ttttacacta gggagtttgg gctgtcattc attcgttcag cagacctttt ttgggcactc    840

tgccaggcag ggtaggagag gtgcctggat ggatagggca taattgggcc agacagacac    900

ggttcttagc cttttggagc ttaaagtgtc ttgagaaacg cagacagggt aagccagcat    960

cgtgcctgac acagaatgtc atgtggcctg tgttttggac cgtggttcgt acctatgctc   1020

cttatgtcac attccctgtt gccttcgtgg tcggggctgt gggttaccac ctggaatggt   1080

tcatcagggg aaaggacccc cagcccgtgg aggaggaaaa gagcatctca gagcgccggg   1140

aggatcgcaa gctggatgag cttctaggca aggaccacac gcaggtggtg agccttaagg   1200

acaagctaga atttgccccg aaagctgtgc tgaacagaaa ccgcccagag aagaattaat   1260

ggaggacaca gggccctatg gtcctactgt gggtggtgac ttgtcctgct accatgttga   1320

cagagcccca gaacccacat ctaattggct ttgttgctta ttctggccct tcccacacca   1380

cacagccaca caaatactgg ctgctccttg atggccaggc agacccagca gcagccgagg   1440

ggccagtgaa gaggaaggcc gcatctgttg tgtggtggcc acaagcactc aggcatctga   1500

gtttactggt gcactgctgg gaggagagtt atgagatgaa cattggctgt caatctctgt   1560

gggcaggcgg tttggcctct agtgggaatg gctgggattt gggcgttgcc tttaggaggg   1620

atacctgcat gtctagttcc agtctgcact ggaaagaatt caaatatgca cctggctccc   1680

ttcactattt tgccctatcc tttgtgctca ttcttactga aatctgtctt gtcagctcag   1740

gaatgggatt cccccaggaa ggaaagcact tttctgttct gggaagccca gactgttcac   1800

tttggggcag ggacgaacat gtgcctcgtg aatttgcttg aaaacagtca ccatcttcta   1860

cccccatcac tgtatagtga aaaacctgat taaagtggta tctgagaacc ataatgatcg   1920


<210>  5735
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  5735

Met Ser Cys Gly Leu Cys Phe Gly Pro Trp Phe Val Pro Met Leu Leu 
1               5                   10                  15      


Met Ser His Ser Leu Leu Pro Ser Trp Ser Gly Leu Trp Val Thr Thr 
            20                  25                  30          


Trp Asn Gly Ser Ser Gly Glu Arg Thr Pro Ser Pro Trp Arg Arg Lys 
        35                  40                  45              


Arg Ala Ser Gln Ser Ala Gly Arg Ile Ala Ser Trp Met Ser Phe 
    50                  55                  60              


<210>  5736
<211>  1085
<212>  DNA
<213>  Homosapiens

<400>  5736
ctgcgctccg agagagccgg cggccagtgg gcagggtcac agggcaaggt cccgcgggcc     60

gctgggtgcg gcgacttccg tgctcccggc gagcgggcgg agagcggggg ccgcactggg    120

gagtgtgggc tgggccgcag atgtcatgtg gcctgtgttt tggaccgtgg ttcgtaccta    180

tgctccttat gtcacattcc ctgttgcctt cgtggtcggg gctgtgggtt accacctgga    240

atggttcatc aggggaaagg acccccagcc cgtggaggag gaaaagagca tctcagagcg    300

ccgggaggat cgcaagctgg atgagcttct aggcaaggac cacacgcagg tggtgagcct    360

taaggacaag ctagaatttg ccccgaaagc tgtgctgaac agaaaccgcc cagagaagaa    420

ttaatggagg acacagggcc ctatggtcct actgtgggtg gtgacttgtc ctgctaccat    480

gttgacagag ccccagaacc cacatctaat tggctttgtt gcttattctg gcccttccca    540

caccacacag ccacacaaat actggctgct ccttgatggc caggcagacc cagcagcagc    600

cgaggggcca gtgaagagga aggccgcatc tgttgtgtgg tggccacaag cactcaggca    660

tctgagttta ctggtgcact gctgggagga gagttatgag atgaacattg gctgtcaatc    720

tctgtgggca ggcggtttgg cctctagtgg gaatggctgg gatttgggcg ttgcctttag    780

gagggatacc tgcatgtcta gttccagtct gcactggaaa gaattcaaat atgcacctgg    840

ctcccttcac tattttgccc tatcctttgt gctcattctt actgaaatct gtcttgtcag    900

ctcaggaatg ggattccccc aggaaggaaa gcacttttct gttctgggaa gcccagactg    960

ttcactttgg ggcagggacg aacatgtgcc tcgtgaattt gcttgaaaac agtcaccatc   1020

ttctaccccc atcactgtat agtgaaaaac ctgattaaag tggtatctga gaaccataat   1080

gatcg                                                               1085


<210>  5737
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  5737

Met Ser Cys Gly Leu Cys Phe Gly Pro Trp Phe Val Pro Met Leu Leu 
1               5                   10                  15      


Met Ser His Ser Leu Leu Pro Ser Trp Ser Gly Leu Trp Val Thr Thr 
            20                  25                  30          


Trp Asn Gly Ser Ser Gly Glu Arg Thr Pro Ser Pro Trp Arg Arg Lys 
        35                  40                  45              


Arg Ala Ser Gln Ser Ala Gly Arg Ile Ala Ser Trp Met Ser Phe 
    50                  55                  60              


<210>  5738
<211>  1396
<212>  DNA
<213>  Homosapiens

<400>  5738
ttcagcagtt cttccggctg tgtcagcaaa gcatggatcc cactgcgttc cctgtgccca     60

ccttccagga cctggcgggt ttctgggacc tcctacagct ctccatcgag gatgtgaccc    120

tcaagttcct ggagctacag caactcaagg ccaacagctg gaaactcctg gagcctaagg    180

aggagaagaa ggtccctccg ccgataccaa agaagccccg gcccccgggc ccgtcacact    240

ctcgtgggtt ttttaccttc ctgatcccac gcgaaggcgc ccgggctggg cagggggccg    300

tgcctctccg ccctgcgccc ctcacctgga tcccctgccc acctggtccg acgctttgtc    360

cccacctcct ccccatgggc accatctctg ccattctttc ccccacgggc caggccgggc    420

cgggtccctc atctgggctc tgcgtccccc cctcccccac cccgcggggc tgggcttcgt    480

ggggatcaag cttcgtggct ttttatgaag aatcccgaac cctgcctagg agcccgcccc    540

accctcccag gggctccatc ctcagccctc tgcccactgg gcccagggac cacagtggct    600

ggaccaaccc aggaccaggg cgcctgggcc tctccccttt cccagcggct ggggagggga    660

gatgggggct tcccctcacc acacctgtgg ctgttcccac atccccttga atatcccagg    720

aaaaataaaa cggcagaact gcactcgagc cagctgctct ctccagaaga ggccacctcc    780

gtcccgtgtg tgggaggacg ggggtgaagg gagaagggac cgggagccca ctctcttggt    840

ttggagatag caggggttgc ctgagctcct tccagggatg ggccagctgg tggaaaggag    900

attcggcccc ctgatgccca cagtaagggc ctggaccctc ctggaggggc ccaggtgggg    960

tgaagagggg gagggtgcca agctctccgt tcttcctatt tcggtgtatc ccgttctgcc   1020

tcccagtccg cagggttccc ccagagaggg aagtccggag ctcgccgggc acgcagcatg   1080

tgctcaataa accgggagtg tggttattgt taggtattga caaataattg gtttcccttc   1140

ccctaggggc acaatgttcc ttctgctcca gtcattcctg atcagcagca gaaaatcttc   1200

agtcctgccg cattttctga tgcctcctat gggtggccac cttggtggag gctggggtgg   1260

gggaagagga agtacaaaga acagagctct cctgggaagc taaatggcaa ccagaaccta   1320

gtatcgatgg ctttattgag tggtcagtgt gggtcaggca aggggtgagt gctttacatg   1380

aatgtggctg gtcctt                                                   1396


<210>  5739
<211>  225
<212>  PRT
<213>  Homosapiens

<400>  5739

Met Asp Pro Thr Ala Phe Pro Val Pro Thr Phe Gln Asp Leu Ala Gly 
1               5                   10                  15      


Phe Trp Asp Leu Leu Gln Leu Ser Ile Glu Asp Val Thr Leu Lys Phe 
            20                  25                  30          


Leu Glu Leu Gln Gln Leu Lys Ala Asn Ser Trp Lys Leu Leu Glu Pro 
        35                  40                  45              


Lys Glu Glu Lys Lys Val Pro Pro Pro Ile Pro Lys Lys Pro Arg Pro 
    50                  55                  60                  


Pro Gly Pro Ser His Ser Arg Gly Phe Phe Thr Phe Leu Ile Pro Arg 
65                  70                  75                  80  


Glu Gly Ala Arg Ala Gly Gln Gly Ala Val Pro Leu Arg Pro Ala Pro 
                85                  90                  95      


Leu Thr Trp Ile Pro Cys Pro Pro Gly Pro Thr Leu Cys Pro His Leu 
            100                 105                 110         


Leu Pro Met Gly Thr Ile Ser Ala Ile Leu Ser Pro Thr Gly Gln Ala 
        115                 120                 125             


Gly Pro Gly Pro Ser Ser Gly Leu Cys Val Pro Pro Ser Pro Thr Pro 
    130                 135                 140                 


Arg Gly Trp Ala Ser Trp Gly Ser Ser Phe Val Ala Phe Tyr Glu Glu 
145                 150                 155                 160 


Ser Arg Thr Leu Pro Arg Ser Pro Pro His Pro Pro Arg Gly Ser Ile 
                165                 170                 175     


Leu Ser Pro Leu Pro Thr Gly Pro Arg Asp His Ser Gly Trp Thr Asn 
            180                 185                 190         


Pro Gly Pro Gly Arg Leu Gly Leu Ser Pro Phe Pro Ala Ala Gly Glu 
        195                 200                 205             


Gly Arg Trp Gly Leu Pro Leu Thr Thr Pro Val Ala Val Pro Thr Ser 
    210                 215                 220                 


Pro 
225 


<210>  5740
<211>  3559
<212>  DNA
<213>  Homosapiens

<400>  5740
atgggcccaa ggctgaggga agagtcccgg cacggcaaga ggagcaagag caaggaccgc     60

aagggggatg ggcggcacca ggccaagtcc acaggctggt ggagttccga tgacaacttg    120

gacagtgata gcggcttcct ggcgggtggg aggccccctg gggagcctgg tggtcccttc    180

tgcctggagg gtccagatgg gtcctaccgg gacttgagct tcaaggggcg ctcgggcggg    240

tcggaaggcc gctgccttgc ctgcactggc atgtccatgt cactggatgg acagtcggtc    300

aagcgaagtg cctggcatac catgatggtc agccagggcc gggatggata cccgggggcc    360

gggccaggca aggggctcct gggtccggag accaaggcca aagccaggac ttatcactat    420

ctgcaggtgc cgcaagatga ctgggggggt taccccaccg gtggcaagga tggggagatc    480

ccctgccgca ggatgcggag cggcagctac atcaaagcca tgggggatga ggagagcgga    540

gactcagacg gcagccccaa gacatctccc aaagcagtcg cccgacgctt caccacccgt    600

cgctcctcca gcgtggacca ggccaggatc aactgctgtg tcccaccccg gatccacccc    660

cggagctcca tccctggcta cagccgttcc ctcaccactg gacagctcag cgatgagttg    720

aaccagcagc tggaggccgt gtgcgggtcg gtgtttgggg agctggagtc ccaggccgtg    780

gacgccctgg acctgcccgg ctgtttccgc atgcggagcc acagctacct ccgggccatc    840

caggccggct gctctcaaga cgacgactgc ctgcccctcc tcgctacccc tgccgctgtc    900

tcagggaggc ccggctcctc cttcaacttc agaaaggccc cgccccccat cccgccggga    960

agccaggccc cgccccgcat ctccatcacc gcccagagca gcaccgactc cgcgcacgag   1020

agcttcacgg cggccgaggg ccccgcccgg cgctgcagct ccgccgacgg gctggacggc   1080

cccgccatgg gtgcgcgcac actggagttg gcgccggtgc cgccccgggc cagccccaag   1140

ccccccacac tcatcatcaa gaccatccct ggcagggagg agctgcggag cctggcgcgg   1200

cagcggaagt ggcggccgtc cattggggtg caggtggaga cgatctcaga ttcggacacc   1260

gagaacagga gccggaggga gttccactct attggcgtgc aggtggaaga ggacaagagg   1320

cgagcaaggt tcaagcgctc caatagtgtg acggctggcg tgcaggcaga cctggagctg   1380

gagggcctgg caggcctggc cacggtggcc acagaagaca aggccctgca gtttggacgc   1440

tccttccaga ggcacgcctc tgagccccag cctgggcccc gggcccccac ctactcagtc   1500

ttccgcacgg tccacacgca gggccagtgg gcctaccgcg agggctaccc actgccgtac   1560

gagccgccgg ccaccgatgg gtcgcccggc cctgcccccg cccccacccc cggccctggg   1620

gccggccgcc gtgactcctg gatagagcgc ggttcacgta gcctccccga ctcaggccgc   1680

gcatccccct gcccacgcga cggcgagtgg ttcatcaaga tgctgcgggc agaggtggag   1740

aagctggagc actggtgcca gcagatggag cgtgaggcgg aggactatga gctacccgag   1800

gagatcctgg agaagatccg cagtgctgtg ggcagcacac aacttctcct gtcccagaag   1860

gttcagcagt tcttccggct gtgtcagcaa agcatggatc ccactgcgtt ccctgtgccc   1920

accttccagg acctggcggg tttctgggac ctcctacagc tctccatcga ggatgtgacc   1980

ctcaagttcc tggagctaca gcaactcaag gccaacagct ggaaactcct ggagcctaag   2040

gaggagaaga aggtccctcc gccgatacca aagaagcccc tgcggggccg gggcgtgccg   2100

gtgaaggagc gctccctgga ctccgtggac cggcagcggc aggaagcgcg caagcggctc   2160

ctggcggcca agcgcgccgc ttccttccgc cacagctcgg ccaccgagag cgccgacagc   2220

atcgagatct acatccccga ggcccagacc aggctgtgac cggtccggcc cgcccagccc   2280

ggcccgggcc cgcggttctc cacccgtact gtacacccag cgtcgaggtc actgtgaacg   2340

cgggccgccc cgtgcgcccg ccccaccggc accggacgcc ccggcccccg ggcccgtcac   2400

actctcgtgg gttttttacc ttcctgatcc cacgcgaagg cgcccgggct gggcaggggg   2460

ccgtgcctct ccgccctgcg cccctcacct ggatcccctg cccacctggt ccgacgcttt   2520

gtccccacct cctccccatg ggcaccatct ctgccattct ttcccccacg ggccaggccg   2580

ggccgggtcc ctcatctggg ctctgcgtcc ccccctcccc caccccgcgg ggctgggctt   2640

cgtggggatc aagcttcgtg gctttttatg aagaatcccg aaccctgcct aggagcccgc   2700

cccaccctcc caggggctcc atcctcagcc ctctgcccac tgggcccagg gaccacagtg   2760

gctggaccaa cccaggacca gggcgcctgg gcctctcccc tttcccagcg gctggggagg   2820

ggagatgggg gcttcccctc accacacctg tggctgttcc cacatcccct tgaatatccc   2880

aggaaaaata aaacggcaga actgcactcg agccagctgc tctctccaga agaggccacc   2940

tccgtcccgt gtgtgggagg acgggggtga agggagaagg gaccgggagc ccactctctt   3000

ggtttggaga tagcaggggt tgcctgagct ccttccaggg atgggccagc tggtggaaag   3060

gagattcggc cccctgatgc ccacagtaag ggcctggacc ctcctggagg ggcccaggtg   3120

gggtgaagag ggggagggtg ccaagctctc cgttcttcct atttcggtgt atcccgttct   3180

gcctcccagt ccgcagggtt cccccagaga gggaagtccg gagctcgccg ggcacgcagc   3240

atgtgctcaa taaaccggga gtgtggttat tgttaggtat tgacaaataa ttggtttccc   3300

ttcccctagg ggcacaatgt tccttctgct ccagtcattc ctgatcagca gcagaaaatc   3360

ttcagtcctg ccgcattttc tgatgcctcc tatgggtggc caccttggtg gaggctgggg   3420

tgggggaaga ggaagtacaa agaacagagc tctcctggga agctaaatgg caaccagaac   3480

ctagtatcga tggctttatt gagtggtcag tgtgggtcag gcaaggggtg agtgctttac   3540

atgaatgtgg ctggtcctt                                                3559


<210>  5741
<211>  752
<212>  PRT
<213>  Homosapiens

<400>  5741

Met Gly Pro Arg Leu Arg Glu Glu Ser Arg His Gly Lys Arg Ser Lys 
1               5                   10                  15      


Ser Lys Asp Arg Lys Gly Asp Gly Arg His Gln Ala Lys Ser Thr Gly 
            20                  25                  30          


Trp Trp Ser Ser Asp Asp Asn Leu Asp Ser Asp Ser Gly Phe Leu Ala 
        35                  40                  45              


Gly Gly Arg Pro Pro Gly Glu Pro Gly Gly Pro Phe Cys Leu Glu Gly 
    50                  55                  60                  


Pro Asp Gly Ser Tyr Arg Asp Leu Ser Phe Lys Gly Arg Ser Gly Gly 
65                  70                  75                  80  


Ser Glu Gly Arg Cys Leu Ala Cys Thr Gly Met Ser Met Ser Leu Asp 
                85                  90                  95      


Gly Gln Ser Val Lys Arg Ser Ala Trp His Thr Met Met Val Ser Gln 
            100                 105                 110         


Gly Arg Asp Gly Tyr Pro Gly Ala Gly Pro Gly Lys Gly Leu Leu Gly 
        115                 120                 125             


Pro Glu Thr Lys Ala Lys Ala Arg Thr Tyr His Tyr Leu Gln Val Pro 
    130                 135                 140                 


Gln Asp Asp Trp Gly Gly Tyr Pro Thr Gly Gly Lys Asp Gly Glu Ile 
145                 150                 155                 160 


Pro Cys Arg Arg Met Arg Ser Gly Ser Tyr Ile Lys Ala Met Gly Asp 
                165                 170                 175     


Glu Glu Ser Gly Asp Ser Asp Gly Ser Pro Lys Thr Ser Pro Lys Ala 
            180                 185                 190         


Val Ala Arg Arg Phe Thr Thr Arg Arg Ser Ser Ser Val Asp Gln Ala 
        195                 200                 205             


Arg Ile Asn Cys Cys Val Pro Pro Arg Ile His Pro Arg Ser Ser Ile 
    210                 215                 220                 


Pro Gly Tyr Ser Arg Ser Leu Thr Thr Gly Gln Leu Ser Asp Glu Leu 
225                 230                 235                 240 


Asn Gln Gln Leu Glu Ala Val Cys Gly Ser Val Phe Gly Glu Leu Glu 
                245                 250                 255     


Ser Gln Ala Val Asp Ala Leu Asp Leu Pro Gly Cys Phe Arg Met Arg 
            260                 265                 270         


Ser His Ser Tyr Leu Arg Ala Ile Gln Ala Gly Cys Ser Gln Asp Asp 
        275                 280                 285             


Asp Cys Leu Pro Leu Leu Ala Thr Pro Ala Ala Val Ser Gly Arg Pro 
    290                 295                 300                 


Gly Ser Ser Phe Asn Phe Arg Lys Ala Pro Pro Pro Ile Pro Pro Gly 
305                 310                 315                 320 


Ser Gln Ala Pro Pro Arg Ile Ser Ile Thr Ala Gln Ser Ser Thr Asp 
                325                 330                 335     


Ser Ala His Glu Ser Phe Thr Ala Ala Glu Gly Pro Ala Arg Arg Cys 
            340                 345                 350         


Ser Ser Ala Asp Gly Leu Asp Gly Pro Ala Met Gly Ala Arg Thr Leu 
        355                 360                 365             


Glu Leu Ala Pro Val Pro Pro Arg Ala Ser Pro Lys Pro Pro Thr Leu 
    370                 375                 380                 


Ile Ile Lys Thr Ile Pro Gly Arg Glu Glu Leu Arg Ser Leu Ala Arg 
385                 390                 395                 400 


Gln Arg Lys Trp Arg Pro Ser Ile Gly Val Gln Val Glu Thr Ile Ser 
                405                 410                 415     


Asp Ser Asp Thr Glu Asn Arg Ser Arg Arg Glu Phe His Ser Ile Gly 
            420                 425                 430         


Val Gln Val Glu Glu Asp Lys Arg Arg Ala Arg Phe Lys Arg Ser Asn 
        435                 440                 445             


Ser Val Thr Ala Gly Val Gln Ala Asp Leu Glu Leu Glu Gly Leu Ala 
    450                 455                 460                 


Gly Leu Ala Thr Val Ala Thr Glu Asp Lys Ala Leu Gln Phe Gly Arg 
465                 470                 475                 480 


Ser Phe Gln Arg His Ala Ser Glu Pro Gln Pro Gly Pro Arg Ala Pro 
                485                 490                 495     


Thr Tyr Ser Val Phe Arg Thr Val His Thr Gln Gly Gln Trp Ala Tyr 
            500                 505                 510         


Arg Glu Gly Tyr Pro Leu Pro Tyr Glu Pro Pro Ala Thr Asp Gly Ser 
        515                 520                 525             


Pro Gly Pro Ala Pro Ala Pro Thr Pro Gly Pro Gly Ala Gly Arg Arg 
    530                 535                 540                 


Asp Ser Trp Ile Glu Arg Gly Ser Arg Ser Leu Pro Asp Ser Gly Arg 
545                 550                 555                 560 


Ala Ser Pro Cys Pro Arg Asp Gly Glu Trp Phe Ile Lys Met Leu Arg 
                565                 570                 575     


Ala Glu Val Glu Lys Leu Glu His Trp Cys Gln Gln Met Glu Arg Glu 
            580                 585                 590         


Ala Glu Asp Tyr Glu Leu Pro Glu Glu Ile Leu Glu Lys Ile Arg Ser 
        595                 600                 605             


Ala Val Gly Ser Thr Gln Leu Leu Leu Ser Gln Lys Val Gln Gln Phe 
    610                 615                 620                 


Phe Arg Leu Cys Gln Gln Ser Met Asp Pro Thr Ala Phe Pro Val Pro 
625                 630                 635                 640 


Thr Phe Gln Asp Leu Ala Gly Phe Trp Asp Leu Leu Gln Leu Ser Ile 
                645                 650                 655     


Glu Asp Val Thr Leu Lys Phe Leu Glu Leu Gln Gln Leu Lys Ala Asn 
            660                 665                 670         


Ser Trp Lys Leu Leu Glu Pro Lys Glu Glu Lys Lys Val Pro Pro Pro 
        675                 680                 685             


Ile Pro Lys Lys Pro Leu Arg Gly Arg Gly Val Pro Val Lys Glu Arg 
    690                 695                 700                 


Ser Leu Asp Ser Val Asp Arg Gln Arg Gln Glu Ala Arg Lys Arg Leu 
705                 710                 715                 720 


Leu Ala Ala Lys Arg Ala Ala Ser Phe Arg His Ser Ser Ala Thr Glu 
                725                 730                 735     


Ser Ala Asp Ser Ile Glu Ile Tyr Ile Pro Glu Ala Gln Thr Arg Leu 
            740                 745                 750         


<210>  5742
<211>  1027
<212>  DNA
<213>  Homosapiens

<400>  5742
atgaaccgtt cttgtgagca gcagggtcgg ctgtgcgtgg ccgtgacact tcgggtgcct     60

gttcctgggt ccccggggag ggggatctca ttcctgcccc tacgctgggc gcccccagca    120

ccgtcgctca gcgagcctcc gtggcttggc cgcctcccgc tcccgcgccc gctgccgctc    180

ggcgctcgct tggggctccg cagccggcgc ggcccctcag ctgggggctc cgcagtgccg    240

ggccccggtc cctgcccgcc tgcccaacgc cgcagcgccc ccggcccggg ccgccggcac    300

catgtaaccc ggccggagcc cgagccgggc caggattcag tggtcctgag ccttctgaag    360

ttaggcttct gcctggtggt ggggatcctg acatcaagga tgggacaccc tggatggagg    420

ttcctggggc ctggccccca agactatgaa gagcctttgc tgaggccatg aggggttacc    480

atggcgaccg aggcagccat ccccgcccag cccgctttgc tgaccaacag catatggacg    540

tgggccctgc tgccagggcc ccatacctgc tgggctccag ggaggccttc tccaccgagc    600

cccgcttctg tgccccgaga gctggcctgg gacacatttc tcctgaaggg cccctgagcc    660

tgagtgaggg gccgtcggta ggccctgagg gagggccagc gggggccggg gttggggggg    720

gtagcagcac cttccccagg atgtaccctg gccagggccc cttcgacacc tgtgaagact    780

gtgtgggcca cccacagggc aagggtgccc cccgcctgcc tcctacactc ctggatcagt    840

ttgaaaagca gttgccagtt caacaagatg gcttccacac actaccatac cagcgagggc    900

cagcaggggc agggcccggg ccagcgccag ggacgggcac tgccccagag ccccgcagtg    960

agagccctag ccgcatccgg cacctggttc attctgtgca gaagctcttt gccaagtccc   1020

actctct                                                             1027


<210>  5743
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  5743

Met Asn Arg Ser Cys Glu Gln Gln Gly Arg Leu Cys Val Ala Val Thr 
1               5                   10                  15      


Leu Arg Val Pro Val Pro Gly Ser Pro Gly Arg Gly Ile Ser Phe Leu 
            20                  25                  30          


Pro Leu Arg Trp Ala Pro Pro Ala Pro Ser Leu Ser Glu Pro Pro Trp 
        35                  40                  45              


Leu Gly Arg Leu Pro Leu Pro Arg Pro Leu Pro Leu Gly Ala Arg Leu 
    50                  55                  60                  


Gly Leu Arg Ser Arg Arg Gly Pro Ser Ala Gly Gly Ser Ala Val Pro 
65                  70                  75                  80  


Gly Pro Gly Pro Cys Pro Pro Ala Gln Arg Arg Ser Ala Pro Gly Pro 
                85                  90                  95      


Gly Arg Arg His His Val Thr Arg Pro Glu Pro Glu Pro Gly Gln Asp 
            100                 105                 110         


Ser Val Val Leu Ser Leu Leu Lys Leu Gly Phe Cys Leu Val Val Gly 
        115                 120                 125             


Ile Leu Thr Ser Arg Met Gly His Pro Gly Trp Arg Phe Leu Gly Pro 
    130                 135                 140                 


Gly Pro Gln Asp Tyr Glu Glu Pro Leu Leu Arg Pro 
145                 150                 155     


<210>  5744
<211>  632
<212>  DNA
<213>  Homosapiens

<400>  5744
atggagttac agtgtgtcta agtttcttgt attttggagt ctgattaact tcagactttg     60

ataagttaag tatatatgct aaaatttcta gagcaatcat taaaagaata gaaagaatgt    120

ataaattcca aaatagttgt aggaaatttg aaataagaga cattcaagag aagtggaaat    180

ccaagtacca tttcagaatg attaaactgt gtggggatag tggtaaaaga tgaggttaat    240

gatataggaa ttgacctcat aggttgtgat gtataaaata tataatatat atataatcta    300

agctttatgt atatgtgtgt gtgtgtgtgt gttccagcct gggcaacaga gcaagactcc    360

atctcaaaaa ctatatatat atatatatat ggattagaca acattggcta agagtttata    420

ataattgaat ctgggtaaca aatacatggg gagatatttt tctattttat ttaaaaaata    480

tgtttgaaac ttgtcatgat aaaaagttaa aaaattgtaa cttagttctt gattcttaac    540

tttttcatac taatttcaga atcaggttat caaattgcat gtattttgat tgaaattgca    600

ttgaatctag ggattaatat tggaagaact ga                                  632


<210>  5745
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  5745

Met Tyr Met Cys Val Cys Val Cys Val Pro Ala Trp Ala Thr Glu Gln 
1               5                   10                  15      


Asp Ser Ile Ser Lys Thr Ile Tyr Ile Tyr Ile Tyr Gly Leu Asp Asn 
            20                  25                  30          


Ile Gly 
        


<210>  5746
<211>  3160
<212>  DNA
<213>  Homosapiens

<400>  5746
gcgcggccat ggcgctcctg ctttcggtgc tgcgtgtact gctgggcggc ttcttcgcgc     60

tcgtggggtt ggccaagctc tcggaggaga tctcggctcc agtttcggag cggatggtca    120

gagatgaaca gcagtgttgg ggacctgggt gttggcggct gcagcctctg ggatgaccct    180

gctcgcttca tcgtggtgcc cgcggcctat gccttggcac tgggcctggg gctgccagcc    240

aacgtggcgg ccctggcaat gttcatccgc agcggcgggc gcctgggcca ggccctgctt    300

ctctacctgt tcaacctggc tctggttgat gagttcttca cgctcacgct gcagctgtgg    360

ctcacctact acctgggcct ggcccggagg ccgcctgcca cgcggccggg gccacctact    420

acgtgtccac ctatgcggcg gtggtcttcg ccgcgctcat cagcgtgtgc cgctgcggct    480

tcgtacgcgg tcccgggccc agggcggctg cccgcctggc ccggtgccta cggcgccccg    540

cgcgcgctgc ctgcgccttc gcctggctgg cgggcctggc ccctccctgc ctggagcacc    600

gctgggcaag ctcggggctg gcctccgcca cggtggcctt cgcggccgcc ttcctgctgg    660

tgctcgcggc caacgtgagc ctggcgcggg cgctcaaggc gccctctggc ccgggcccgg    720

gccctgcaac cgccggcgcg caccggcgcg cggccaagac catggtcctg gggttcctgc    780

tggtcttcgc cctcagtctg gcgcccaacc acctgctgct ggcgccctag gtggctgggg    840

gggaagacaa cggagaccgg tgtcgcgccg cctccacgct cgacatcctg cacaccctca    900

gcctggcgct gctgagcctc aacagctgcc tggacccact catctgctgc ttcttcgtgc    960

gcctcttcca ccaggactgc tgctgggcac tgagctgccg cctggtgaag ggggcgccca   1020

gggcgcatgg ggcctccttg gcctcctctt ggagagtctc ctggcctccc ctcctgtctc   1080

acccccctgt caccctccca gtggcatcca gggtggagaa agctctttgg aaagacctag   1140

attctaatcc tgacgcaacc acatactacc cctgtagctg tgaacctccg ggctcatctg   1200

taccaaggac atagaacatt ctttgtaacc cgaatgttcc ctggatgttg ccagcttttg   1260

gatacaaata atataccact gtgttttttt taaacctctt gggataaaac ccaaagtcct   1320

tatcatggcc tacaaggccc tgtctgattt ggctcccctt tctctcccta acccaccacc   1380

cctgcgtctc cctgcaggca gtcaccttct taggcccggg aaaatgccgg tctcctactc   1440

ttcatggcct ttgtacctga cttggccagg aatgatctct gttcctctct ttcactaagt   1500

tagttcttct tcaccctcac ttcctctaaa gtaactcctt atagggaagc ctttcttggc   1560

tggcaacaca cacacacaca cacacacaca catacacaca cgactgaatc agatcggatt   1620

gctctttgat agctcttttc ataattgtaa tcaagcaatt aattgggtaa tgcgttgttg   1680

ttgttttctt tctctcttgc cagaatgtat tcatgttgac ccataagaca ttatcatttt   1740

tataagtccc caaaagttga atattggaaa ttttatttcc acccaattca acttaataaa   1800

ttctgtgttt accttgctca ctgctgtatc tcctgtggtt ggtactgtgc cttgcatata   1860

ataagagctc agtgtatcag atgcgtgagt gaaaactgaa tatcattaat ttaaattgct   1920

taagtactca ctcagacatt ccagtctctg atagcttttc ctcaagtgtt tctgagattc   1980

tccaagcttg tcttacccac ccccgaccat gcattcctag cccagtcctg atgactgtct   2040

ccttctgctg ttgctggata cttgcagttc tgccatcacc tccactgtac caagacttgg   2100

tgggaagtaa gctggagatc caggctgctg gagatccaat gcctgctgcc tccagactct   2160

ttcatgagcg ccaatctctg ccaggggctc cggctaccag tgcttcccct tctgtgcttt   2220

gacaactctg cagtctgctt ctaatgggaa agggcaccac tctcctcagc cacattattg   2280

gggccccaca gcaagactgc ttgggtctca aggaaatcga gcttaatgaa tgagagcaaa   2340

ccctcttcat ttggccatgt cagcttgtca ggaagggtcc atcaatcagc caccatgtct   2400

tacctgcctt taggtcctat tgctgagttt gacttctaag gatacatttg gtaaattcct   2460

ttttttcttg atgaattacc tcttattggt ccctaattcc ttctttaact tttttctttt   2520

ccattttaaa agcaatatag gttcataaaa gtaaattcaa agcagtagag aaaaatgtaa   2580

gataggaagt actagcctgg gcaacgtggc gaaaccctgt ctctacaaaa aatacaaaaa   2640

ttagccgggc gtggtcctag ctactcggga gactgaagtg gaaggcttgc ttgagcccag   2700

gaggtcaagg ctgcagtgag ccgtgatggc gccactgcac ttcagccttg gagacagggg   2760

agaccctatg tcaaaaaaga aataaaaaga aagtaaaagt cccctagtga tagccactat   2820

tcacagcttc tcatttgtgt agctttccag atattttcga ttccactgta agtccacatg   2880

tcatcagttt tctttaaaaa cctacaaatg ggatagtatt gcaaggttct tctgcaattt   2940

acttttctca ttgtttctta tatattgttc tatattagca catatagata gattcatctc   3000

gttttttcaa tagaagcaga gtattcgttt tactcaattg gtcccctact gatgggcatt   3060

tgttgccatt attttactgt tataaacaat gcttcagtga atgctcttgt taacaaatgt   3120

ttgcatactt gtaaatctgt agaataaatt cctggcaacg                         3160


<210>  5747
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  5747

Met Ala Leu Leu Leu Ser Val Leu Arg Val Leu Leu Gly Gly Phe Phe 
1               5                   10                  15      


Ala Leu Val Gly Leu Ala Lys Leu Ser Glu Glu Ile Ser Ala Pro Val 
            20                  25                  30          


Ser Glu Arg Met Val Arg Asp Glu Gln Gln Cys Trp Gly Pro Gly Cys 
        35                  40                  45              


Trp Arg Leu Gln Pro Leu Gly 
    50                  55  


<210>  5748
<211>  1885
<212>  DNA
<213>  Homosapiens

<400>  5748
atagcaagag gcaagaaagg aacagtctga ggtttgagtc tgacccagga cctctttgtg     60

gtcaaaaagt gaggggggag gaaacaggat gaaaggcttg agagtggcaa aagcttttca    120

gcccagccaa gggtgctcca ggcaagcgct ggggcacctc tctgggagag gaccttcacc    180

aaggcaaaga tgaacagcag tgttggggac ctgggtgttg gcggctgcag cctctgggat    240

gaccctgctc gcttcatcgt ggtgcccgcg gcctatgcct tggcactggg cctggggctg    300

ccagccaacg tggcggccct ggcaatgttc atccgcagcg gcgggcgcct gggccaggcc    360

ctgcttctct acctgttcaa cctggctctg gttgatgagt tcttcacgct cacgctgcag    420

ctgtggctca cctactacct gggcctggcc cggaggccgc ctgccacgcg gccggggcca    480

cctactacgt gtccacctat gcggcggtgg tcttcgccgc gctcatcagc gtgtgccgct    540

gcggcttcgt acgcggtccc gggcccaggg cggctgcccg cctggcccgg tgcctacggc    600

gccccgcgcg cgctgcctgc gccttcgcct ggctggcggg cctggcccct ccctgcctgg    660

agcaccgctg ggcaagctcg gggctggcct ccgccacggt ggccttcgcg gccgccttcc    720

tgctggtgct cgcggccaac gtgagcctgg cgcgggcgct caaggcgccc tctggcccgg    780

gcccgggccc tgcaaccgcc ggcgcgcacc ggcgcgcggc caagaccatg gtcctggggt    840

tcctgctggt cttcgccctc agtctggcgc ccaaccacct gctgctggcg ccctaggtgg    900

ctggggggga agacaacgga gaccggtgtc gcgccgcctc cacgctcgac atcctgcaca    960

ccctcagcct ggcgctgctg agcctcaaca gctgcctgga cccactcatc tgctgcttct   1020

tcgtgcgcct cttccaccag gactgctgct gggcactgag ctgccgcctg gtgaaggggg   1080

cgcccagggc gcatggggcc tccttggcct cctcttggag agtctcctgg cctcccctcc   1140

tgtctcaccc ccctgtcacc ctcccagtgg catccagggt ggagaaagct ctttggaaag   1200

acctagattc taatcctgac gcaaccacat actacccctg tagctgtgaa cctccgggct   1260

catctgtacc aaggacatag aacattcttt gtaacccgaa tgttccctgg atgttgccag   1320

cttttggata caaataatat accactgtgt tttttttaaa cctcttggga taaaacccaa   1380

agtccttatc atggcctaca aggccctgtc tgatttggct cccctttctc tccctaaccc   1440

accacccctg cgtctccctg caggcagtca ccttcttagg cccgggaaaa tgccggtctc   1500

ctactcttca tggcctttgt acctgacttg gccaggaatg atctctgttc ctctctttca   1560

ctaagttagt tcttcttcac cctcacttcc tctaaagtaa ctccttatag ggaagccttt   1620

cttggctggc aacacacaca cacacacaca cacacacata cacacacgac tgaatcagat   1680

cggattgctc tttgatagct cttttcataa ttgtaatcaa gcaattaatt gggtaatgcg   1740

ttgttgttgt tttctttctc tcttgccaga atgtattcat gttgacccat aagacattat   1800

catttttata agtccccaaa agttgaatat tggaaatttt atttccaccc aattcaactt   1860

aataaattct gtgtttacct tgctc                                         1885


<210>  5749
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  5749

Met Lys Gly Leu Arg Val Ala Lys Ala Phe Gln Pro Ser Gln Gly Cys 
1               5                   10                  15      


Ser Arg Gln Ala Leu Gly His Leu Ser Gly Arg Gly Pro Ser Pro Arg 
            20                  25                  30          


Gln Arg 
        


<210>  5750
<211>  819
<212>  DNA
<213>  Homosapiens

<400>  5750
aacccacggt ggggggagcg cggccatggc gctcctgctt tcggtgctgc gtgtactgct     60

gggcggcttc ttcgcgctcg tggggttggc caagctctcg gaggagatct cggctccagt    120

ttcggagcgg atgaatgccc tgttcgtgca gtttgctgag gtgttcccgc tgaaggtatt    180

tggctaccag ccagatcccc tgaactacca aatagctgtg ggctttctgg aactgctggc    240

tgggttgctg ctggtcatgg gcccaccgat gctgcaagag atcagtaact tgttcttgat    300

tctgctcatg atgggggcta tcttcacctt ggcagctctg aaagagtcac taagcacctg    360

tatcccagcc attgtctgcc tggggttcct gctgctgctg aatgtcggcc atctctttat    420

gccatgcagc tgtcacagca ggaacatggt agaacacaga gtctatcatc ttgttaccag    480

tataatatcc agggtcagcc agtgttgaaa gagacatttt gtctacctgg cactgctttc    540

tctttttagc tttactactc ttttgtgagg agtacatgtt atgcatatta acattcctca    600

tgtcatatga aaatacaaaa taagcagaaa agaaatttaa atcaaccaaa attctgatgc    660

cccaaataac cacttttaat gccttggtgt aagtatacct ctgaactttt ttctgtgcct    720

ttaaacagat atatattttt tttaaatgaa aataaaacca tatatcctat tttatttcct    780

ccttttaaaa ccttataaac tataacactg tttcatgtc                           819


<210>  5751
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  5751

Met Ala Leu Leu Leu Ser Val Leu Arg Val Leu Leu Gly Gly Phe Phe 
1               5                   10                  15      


Ala Leu Val Gly Leu Ala Lys Leu Ser Glu Glu Ile Ser Ala Pro Val 
            20                  25                  30          


Ser Glu Arg Met Asn Ala Leu Phe Val Gln Phe Ala Glu Val Phe Pro 
        35                  40                  45              


Leu Lys Val Phe Gly Tyr Gln Pro Asp Pro Leu Asn Tyr Gln Ile Ala 
    50                  55                  60                  


Val Gly Phe Leu Glu Leu Leu Ala Gly Leu Leu Leu Val Met Gly Pro 
65                  70                  75                  80  


Pro Met Leu Gln Glu Ile Ser Asn Leu Phe Leu Ile Leu Leu Met Met 
                85                  90                  95      


Gly Ala Ile Phe Thr Leu Ala Ala Leu Lys Glu Ser Leu Ser Thr Cys 
            100                 105                 110         


Ile Pro Ala Ile Val Cys Leu Gly Phe Leu Leu Leu Leu Asn Val Gly 
        115                 120                 125             


His Leu Phe Met Pro Cys Ser Cys His Ser Arg Asn Met Val Glu His 
    130                 135                 140                 


Arg Val Tyr His Leu Val Thr Ser Ile Ile Ser Arg Val Ser Gln Cys 
145                 150                 155                 160 


<210>  5752
<211>  925
<212>  DNA
<213>  Homosapiens

<400>  5752
gggttttcgg cggggccaac ccacggtggg gggagcgcgg ccatggcgct cctgctttcg     60

gtgctgcgtg tactgctggg cggcttcttc gcgctcgtgg ggttggccaa gctctcggag    120

gagatctcgg ctccagtttc ggagcggatg aatgccctgt tcgtgcagtt tgctgaggtg    180

ttcccgctga aggtatttgg ctaccagcca gatcccctga actaccaaat agctgtgggc    240

tttctggaac tgctggctgg gttgctgctg gtcatgggcc caccgatgct gcaagagatc    300

agtaacttgt tcttgattct gctcatgatg ggggctatct tcaccttggc agctctgaaa    360

gagtcactaa gcacctgtat cccagccatt gtctgcctgg ggttcctgct gctgctgaat    420

gtcggccagc tcttagccca gactaagaag gtggtcagac ccactaggaa gaagactcta    480

agtacattca aggaatcctg gaagtagagc atctctgtct ctttatgcca tgcagctgtc    540

acagcaggaa catggtagaa cacagagtct atcatcttgt taccagtata atatccaggg    600

tcagccagtg ttgaaagaga cattttgtct acctggcact gctttctctt tttagcttta    660

ctactctttt gtgaggagta catgttatgc atattaacat tcctcatgtc atatgaaaat    720

acaaaataag cagaaaagaa atttaaatca accaaaattc tgatgcccca aataaccact    780

tttaatgcct tggtgtaagt atacctctga acttttttct gtgcctttaa acagatatat    840

atttttttta aatgaaaata aaaccatata tcctatttta tttcctcctt ttaaaacctt    900

ataaactata acactgtttc atgtc                                          925


<210>  5753
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  5753

Met Ala Leu Leu Leu Ser Val Leu Arg Val Leu Leu Gly Gly Phe Phe 
1               5                   10                  15      


Ala Leu Val Gly Leu Ala Lys Leu Ser Glu Glu Ile Ser Ala Pro Val 
            20                  25                  30          


Ser Glu Arg Met Asn Ala Leu Phe Val Gln Phe Ala Glu Val Phe Pro 
        35                  40                  45              


Leu Lys Val Phe Gly Tyr Gln Pro Asp Pro Leu Asn Tyr Gln Ile Ala 
    50                  55                  60                  


Val Gly Phe Leu Glu Leu Leu Ala Gly Leu Leu Leu Val Met Gly Pro 
65                  70                  75                  80  


Pro Met Leu Gln Glu Ile Ser Asn Leu Phe Leu Ile Leu Leu Met Met 
                85                  90                  95      


Gly Ala Ile Phe Thr Leu Ala Ala Leu Lys Glu Ser Leu Ser Thr Cys 
            100                 105                 110         


Ile Pro Ala Ile Val Cys Leu Gly Phe Leu Leu Leu Leu Asn Val Gly 
        115                 120                 125             


Gln Leu Leu Ala Gln Thr Lys Lys Val Val Arg Pro Thr Arg Lys Lys 
    130                 135                 140                 


Thr Leu Ser Thr Phe Lys Glu Ser Trp Lys 
145                 150                 


<210>  5754
<211>  3339
<212>  DNA
<213>  Homosapiens

<400>  5754
tcagaaacta tttcttgagt ccgttcttct cagagtttat tacttcctcc cacgtcttgg     60

tctgctggtc taattccctt caataacctt caacatagga aaaaaccaga gtgtgttgtg    120

tgtctttaaa gatattagag aagtgggagc tgttgcccca aaactgtttt cttatgtagc    180

tactgaagga acagaaagca ggaagaaaga aaaaagttag ttgtggcccc agaagagttg    240

tttttcaaat gccgagccgt gaagcctcat gcactcaaca caaagttttt ctttcatata    300

gataagcctg aagaaaaaag aataagcctg agtatgtatt ttaggtgtcc aactatccat    360

taccaagaag aaatctattc gtttgagcct gagacactct ttgaggtaaa aaattagaat    420

gaaagaacct ttggatggtg aatgtggcaa agcagtggta ccacagcagg agcttctgga    480

caaaattaaa gaagaaccag acaatgctca agagtatgga tgtgtccaac agccaaaaac    540

tcaagaaagt aaattgaaaa ttggtggtgt gtcttcagtt aatgagagac ctattgccca    600

gcagttgaac ccaggctttc agctttcttt tgcatcatct ggcccaagtg tgttgcttcc    660

ttcagttcca gctgttgcta ttaaggtttt ttgttctggt tgtaaaaaaa tgctttataa    720

gggccaaact gcatatcata agacaggatc tactcagctc ttctgctcca cacgatgcat    780

caccagacat tcttcacctg cctgcctgcc acctcctccc aagaaaacct gcacaaactg    840

ctcgaaagac attttaaatc ctaaggatgt gatcacaact cgctttgaga attcctatcc    900

tagcaaagat ttctgcagcc aatcatgctt gtcatcttat gagctaaaga aaaaacctgt    960

tgttaccata tataccaaaa gcatttcaac taagtgcagt atgtgtcaga agaatgctga   1020

tactcgattt gaagttaaat atcaaaatgt ggtacatggt ctttgtagtg atgcctgttt   1080

ttcaaaattt cactctacaa acaacctcac catgaactgt tgtgagaact gtgggagcta   1140

ttgctatagt agctctggtc cttgccaatc ccagaaggtt tttagttcaa caagtgtcac   1200

ggcatacaag cagaattctg cccaaattcc tccatatgcc ctggggaagt cattgaggcc   1260

ctcagctgaa atgattgaga ctacaaatga ttcaggaaaa acagagcttt tctgctctat   1320

taattgctta tctgcttaca gagttaagac tgttacttct tcaggtgtcc aggtttcatg   1380

tcatagttgt aaaacctcag caatccctca gtatcaccta gccatgtcaa atggaactat   1440

atacagcttc tgcagctcca gttgtgtggt tgctttccag aatgtattta gcaagccaaa   1500

aggaacaaac tcttcggcgg tgcccctgtc tcagggccaa gtggttgtaa gcccgccctc   1560

ctccaggtca gcagtgtcaa taggaggagg taacacctct gccgtttccc ccagctccat   1620

ccgtggctct gctgcagcca gcctccaacc tcttgctgaa caatcccagc aagttgcttt   1680

aacccataca gttgttaaac tcaagtgtca gcactgtaac catctatttg ccacaaaacc   1740

agaacttctt ttttacaagg gtaaaatgtt tctgttttgt ggcaagaatt gctctgatga   1800

atacaagaag aaaaataaag ttgtggcaat gtgtgactac tgtaaactgc agaaaattat   1860

aaaggagact gtgcgattct caggggttga taagccattc tgtagtgaag tttgcaaatt   1920

cctctctgcc cgtgactttg gagaacgatg gggaaactac tgtaagatgt gcagctactg   1980

ttcacagaca tccccaaatt tggtagaaaa tcgattggag ggcaagttag aagagttttg   2040

ttgtgaagat tgtatgtcca aatttacagt tctgttttat cagatggcca agtgtgatgg   2100

ttgtaaacga cagggtaaac taagcgagtc cataaagtgg cgaggcaaca ttaaacattt   2160

ctgtaaccta ttttgtgtct tggagttttg tcatcagcaa attatgaatg actgtcttcc   2220

acaaaataaa gtaaatattt ctaaagcaaa aactgctgtg acggagctcc cttctgcaag   2280

gacagataca acaccagtta taaccagtgt gatgtcattg gcaaaaatac ctgctacctt   2340

atctacaggg aacactaaca gtgttttaaa aggtgcagtt actaaagagg cagcaaagat   2400

cattcaagat gaaagtacac aggaagatgc tatgaaattt ccatcttccc aatcttccca   2460

gccttccagg cttttaaaga acaaaggcat atcatgcaaa cccgtcacac agaccaaggc   2520

cacttcttgc aaaccacata cacagcacaa agaatgtcag acagaatgcc ctgttcgtgc   2580

agtttgctga ggtgttcccg ctgaaggtat ttggctacca gccagatccc ctgaactacc   2640

aaatagctgt gggctttctg gaactgctgg ctgggttgct gctggtcatg ggcccaccga   2700

tgctgcaaga gatcagtaac ttgttcttga ttctgctcat gatgggggct atcttcacct   2760

tggcagctct gaaagagtca ctaagcacct gtatcccagc cattgtctgc ctggggttcc   2820

tgctgctgct gaatgtcggc cagctcttag cccagactaa gaaggtggtc agacccacta   2880

ggaagaagac tctaagtaca ttcaaggaat cctggaagta gagcatctct gtctctttat   2940

gccatgcagc tgtcacagca ggaacatggt agaacacaga gtctatcatc ttgttaccag   3000

tataatatcc agggtcagcc agtgttgaaa gagacatttt gtctacctgg cactgctttc   3060

tctttttagc tttactactc ttttgtgagg agtacatgtt atgcatatta acattcctca   3120

tgtcatatga aaatacaaaa taagcagaaa agaaatttaa atcaaccaaa attctgatgc   3180

cccaaataac cacttttaat gccttggtgt aagtatacct ctgaactttt ttctgtgcct   3240

ttaaacagat atatattttt tttaaatgaa aataaaacca tatatcctat tttatttcct   3300

ccttttaaaa ccttataaac tataacactg tttcatgtc                          3339


<210>  5755
<211>  723
<212>  PRT
<213>  Homosapiens

<400>  5755

Met Lys Glu Pro Leu Asp Gly Glu Cys Gly Lys Ala Val Val Pro Gln 
1               5                   10                  15      


Gln Glu Leu Leu Asp Lys Ile Lys Glu Glu Pro Asp Asn Ala Gln Glu 
            20                  25                  30          


Tyr Gly Cys Val Gln Gln Pro Lys Thr Gln Glu Ser Lys Leu Lys Ile 
        35                  40                  45              


Gly Gly Val Ser Ser Val Asn Glu Arg Pro Ile Ala Gln Gln Leu Asn 
    50                  55                  60                  


Pro Gly Phe Gln Leu Ser Phe Ala Ser Ser Gly Pro Ser Val Leu Leu 
65                  70                  75                  80  


Pro Ser Val Pro Ala Val Ala Ile Lys Val Phe Cys Ser Gly Cys Lys 
                85                  90                  95      


Lys Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr 
            100                 105                 110         


Gln Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala 
        115                 120                 125             


Cys Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Asp 
    130                 135                 140                 


Ile Leu Asn Pro Lys Asp Val Ile Thr Thr Arg Phe Glu Asn Ser Tyr 
145                 150                 155                 160 


Pro Ser Lys Asp Phe Cys Ser Gln Ser Cys Leu Ser Ser Tyr Glu Leu 
                165                 170                 175     


Lys Lys Lys Pro Val Val Thr Ile Tyr Thr Lys Ser Ile Ser Thr Lys 
            180                 185                 190         


Cys Ser Met Cys Gln Lys Asn Ala Asp Thr Arg Phe Glu Val Lys Tyr 
        195                 200                 205             


Gln Asn Val Val His Gly Leu Cys Ser Asp Ala Cys Phe Ser Lys Phe 
    210                 215                 220                 


His Ser Thr Asn Asn Leu Thr Met Asn Cys Cys Glu Asn Cys Gly Ser 
225                 230                 235                 240 


Tyr Cys Tyr Ser Ser Ser Gly Pro Cys Gln Ser Gln Lys Val Phe Ser 
                245                 250                 255     


Ser Thr Ser Val Thr Ala Tyr Lys Gln Asn Ser Ala Gln Ile Pro Pro 
            260                 265                 270         


Tyr Ala Leu Gly Lys Ser Leu Arg Pro Ser Ala Glu Met Ile Glu Thr 
        275                 280                 285             


Thr Asn Asp Ser Gly Lys Thr Glu Leu Phe Cys Ser Ile Asn Cys Leu 
    290                 295                 300                 


Ser Ala Tyr Arg Val Lys Thr Val Thr Ser Ser Gly Val Gln Val Ser 
305                 310                 315                 320 


Cys His Ser Cys Lys Thr Ser Ala Ile Pro Gln Tyr His Leu Ala Met 
                325                 330                 335     


Ser Asn Gly Thr Ile Tyr Ser Phe Cys Ser Ser Ser Cys Val Val Ala 
            340                 345                 350         


Phe Gln Asn Val Phe Ser Lys Pro Lys Gly Thr Asn Ser Ser Ala Val 
        355                 360                 365             


Pro Leu Ser Gln Gly Gln Val Val Val Ser Pro Pro Ser Ser Arg Ser 
    370                 375                 380                 


Ala Val Ser Ile Gly Gly Gly Asn Thr Ser Ala Val Ser Pro Ser Ser 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ala Ala Ser Leu Gln Pro Leu Ala Glu Gln Ser 
                405                 410                 415     


Gln Gln Val Ala Leu Thr His Thr Val Val Lys Leu Lys Cys Gln His 
            420                 425                 430         


Cys Asn His Leu Phe Ala Thr Lys Pro Glu Leu Leu Phe Tyr Lys Gly 
        435                 440                 445             


Lys Met Phe Leu Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys Lys 
    450                 455                 460                 


Lys Asn Lys Val Val Ala Met Cys Asp Tyr Cys Lys Leu Gln Lys Ile 
465                 470                 475                 480 


Ile Lys Glu Thr Val Arg Phe Ser Gly Val Asp Lys Pro Phe Cys Ser 
                485                 490                 495     


Glu Val Cys Lys Phe Leu Ser Ala Arg Asp Phe Gly Glu Arg Trp Gly 
            500                 505                 510         


Asn Tyr Cys Lys Met Cys Ser Tyr Cys Ser Gln Thr Ser Pro Asn Leu 
        515                 520                 525             


Val Glu Asn Arg Leu Glu Gly Lys Leu Glu Glu Phe Cys Cys Glu Asp 
    530                 535                 540                 


Cys Met Ser Lys Phe Thr Val Leu Phe Tyr Gln Met Ala Lys Cys Asp 
545                 550                 555                 560 


Gly Cys Lys Arg Gln Gly Lys Leu Ser Glu Ser Ile Lys Trp Arg Gly 
                565                 570                 575     


Asn Ile Lys His Phe Cys Asn Leu Phe Cys Val Leu Glu Phe Cys His 
            580                 585                 590         


Gln Gln Ile Met Asn Asp Cys Leu Pro Gln Asn Lys Val Asn Ile Ser 
        595                 600                 605             


Lys Ala Lys Thr Ala Val Thr Glu Leu Pro Ser Ala Arg Thr Asp Thr 
    610                 615                 620                 


Thr Pro Val Ile Thr Ser Val Met Ser Leu Ala Lys Ile Pro Ala Thr 
625                 630                 635                 640 


Leu Ser Thr Gly Asn Thr Asn Ser Val Leu Lys Gly Ala Val Thr Lys 
                645                 650                 655     


Glu Ala Ala Lys Ile Ile Gln Asp Glu Ser Thr Gln Glu Asp Ala Met 
            660                 665                 670         


Lys Phe Pro Ser Ser Gln Ser Ser Gln Pro Ser Arg Leu Leu Lys Asn 
        675                 680                 685             


Lys Gly Ile Ser Cys Lys Pro Val Thr Gln Thr Lys Ala Thr Ser Cys 
    690                 695                 700                 


Lys Pro His Thr Gln His Lys Glu Cys Gln Thr Glu Cys Pro Val Arg 
705                 710                 715                 720 


Ala Val Cys 
            


<210>  5756
<211>  3250
<212>  DNA
<213>  Homosapiens

<400>  5756
tcagaaacta tttcttgagt ccgttcttct cagagtttat tacttcctcc cacgtcttgg     60

tctgctggtc taattccctt caataacctt caacatagga aaaaaccaga gtgtgttgtg    120

tgtctttaaa gatattagag aagtgggagc tgttgcccca aaactgtttt cttatgtagc    180

tactgaagga acagaaagca ggaagaaaga aaaaagttag ttgtggcccc agaagagttg    240

tttttcaaat gccgagccgt gaagcctcat gcactcaaca caaagttttt ctttcatata    300

gataagcctg aagaaaaaag aataagcctg agtatgtatt ttaggtgtcc aactatccat    360

taccaagaag aaatctattc gtttgagcct gagacactct ttgaggtaaa aaattagaat    420

gaaagaacct ttggatggtg aatgtggcaa agcagtggta ccacagcagg agcttctgga    480

caaaattaaa gaagaaccag acaatgctca agagtatgga tgtgtccaac agccaaaaac    540

tcaagaaagt aaattgaaaa ttggtggtgt gtcttcagtt aatgagagac ctattgccca    600

gcagttgaac ccaggctttc agctttcttt tgcatcatct ggcccaagtg tgttgcttcc    660

ttcagttcca gctgttgcta ttaaggtttt ttgttctggt tgtaaaaaaa tgctttataa    720

gggccaaact gcatatcata agacaggatc tactcagctc ttctgctcca cacgatgcat    780

caccagacat tcttcacctg cctgcctgcc acctcctccc aagaaaacct gcacaaactg    840

ctcgaaagac attttaaatc ctaaggatgt gatcacaact cgctttgaga attcctatcc    900

tagcaaagat ttctgcagcc aatcatgctt gtcatcttat gagctaaaga aaaaacctgt    960

tgttaccata tataccaaaa gcatttcaac taagtgcagt atgtgtcaga agaatgctga   1020

tactcgattt gaagttaaat atcaaaatgt ggtacatggt ctttgtagtg atgcctgttt   1080

ttcaaaattt cactctacaa acaacctcac catgaactgt tgtgagaact gtgggagcta   1140

ttgctatagt agctctggtc cttgccaatc ccagaaggtt tttagttcaa caagtgtcac   1200

ggcatacaag cagaattctg cccaaattcc tccatatgcc ctggggaagt cattgaggcc   1260

ctcagctgaa atgattgaga ctacaaatga ttcaggaaaa acagagcttt tctgctctat   1320

taattgctta tctgcttaca gagttaagac tgttacttct tcaggtgtcc aggtttcatg   1380

tcatagttgt aaaacctcag caatccctca gtatcaccta gccatgtcaa atggaactat   1440

atacagcttc tgcagctcca gttgtgtggt tgctttccag aatgtattta gcaagccaaa   1500

aggaacaaac tcttcggcgg tgcccctgtc tcagggccaa gtggttgtaa gcccgccctc   1560

ctccaggtca gcagtgtcaa taggaggagg taacacctct gccgtttccc ccagctccat   1620

ccgtggctct gctgcagcca gcctccaacc tcttgctgaa caatcccagc aagttgcttt   1680

aacccataca gttgttaaac tcaagtgtca gcactgtaac catctatttg ccacaaaacc   1740

agaacttctt ttttacaagg gtaaaatgtt tctgttttgt ggcaagaatt gctctgatga   1800

atacaagaag aaaaataaag ttgtggcaat gtgtgactac tgtaaactgc agaaaattat   1860

aaaggagact gtgcgattct caggggttga taagccattc tgtagtgaag tttgcaaatt   1920

cctctctgcc cgtgactttg gagaacgatg gggaaactac tgtaagatgt gcagctactg   1980

ttcacagaca tccccaaatt tggtagaaaa tcgattggag ggcaagttag aagagttttg   2040

ttgtgaagat tgtatgtcca aatttacagt tctgttttat cagatggcca agtgtgatgg   2100

ttgtaaacga cagggtaaac taagcgagtc cataaagtgg cgaggcaaca ttaaacattt   2160

ctgtaaccta ttttgtgtct tggagttttg tcatcagcaa attatgaatg actgtcttcc   2220

acaaaataaa gtaaatattt ctaaagcaaa aactgctgtg acggagctcc cttctgcaag   2280

gacagataca acaccagtta taaccagtgt gatgtcattg gcaaaaatac ctgctacctt   2340

atctacaggg aacactaaca gtgttttaaa aggtgcagtt actaaagagg cagcaaagat   2400

cattcaagat gaaagtacac aggaagatgc tatgaaattt ccatcttccc aatcttccca   2460

gccttccagg cttttaaaga acaaaggcat atcatgcaaa cccgtcacac agaccaaggc   2520

cacttcttgc aaaccacata cacagcacaa agaatgtcag acagaatgcc ctgttcgtgc   2580

agtttgctga ggtgttcccg ctgaaggtat ttggctacca gccagatccc ctgaactacc   2640

aaatagctgt gggctttctg gaactgctgg ctgggttgct gctggtcatg ggcccaccga   2700

tgctgcaaga gatcagtaac ttgttcttga ttctgctcat gatgggggct atcttcacct   2760

tggcagctct gaaagagtca ctaagcacct gtatcccagc cattgtctgc ctggggttcc   2820

tgctgctgct gaatgtcggc catctcttta tgccatgcag ctgtcacagc aggaacatgg   2880

tagaacacag agtctatcat cttgttacca gtataatatc cagggtcagc cagtgttgaa   2940

agagacattt tgtctacctg gcactgcttt ctctttttag ctttactact cttttgtgag   3000

gagtacatgt tatgcatatt aacattcctc atgtcatatg aaaatacaaa ataagcagaa   3060

aagaaattta aatcaaccaa aattctgatg ccccaaataa ccacttttaa tgccttggtg   3120

taagtatacc tctgaacttt tttctgtgcc tttaaacaga tatatatttt ttttaaatga   3180

aaataaaacc atatatccta ttttatttcc tccttttaaa accttataaa ctataacact   3240

gtttcatgtc                                                          3250


<210>  5757
<211>  723
<212>  PRT
<213>  Homosapiens

<400>  5757

Met Lys Glu Pro Leu Asp Gly Glu Cys Gly Lys Ala Val Val Pro Gln 
1               5                   10                  15      


Gln Glu Leu Leu Asp Lys Ile Lys Glu Glu Pro Asp Asn Ala Gln Glu 
            20                  25                  30          


Tyr Gly Cys Val Gln Gln Pro Lys Thr Gln Glu Ser Lys Leu Lys Ile 
        35                  40                  45              


Gly Gly Val Ser Ser Val Asn Glu Arg Pro Ile Ala Gln Gln Leu Asn 
    50                  55                  60                  


Pro Gly Phe Gln Leu Ser Phe Ala Ser Ser Gly Pro Ser Val Leu Leu 
65                  70                  75                  80  


Pro Ser Val Pro Ala Val Ala Ile Lys Val Phe Cys Ser Gly Cys Lys 
                85                  90                  95      


Lys Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr 
            100                 105                 110         


Gln Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala 
        115                 120                 125             


Cys Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Asp 
    130                 135                 140                 


Ile Leu Asn Pro Lys Asp Val Ile Thr Thr Arg Phe Glu Asn Ser Tyr 
145                 150                 155                 160 


Pro Ser Lys Asp Phe Cys Ser Gln Ser Cys Leu Ser Ser Tyr Glu Leu 
                165                 170                 175     


Lys Lys Lys Pro Val Val Thr Ile Tyr Thr Lys Ser Ile Ser Thr Lys 
            180                 185                 190         


Cys Ser Met Cys Gln Lys Asn Ala Asp Thr Arg Phe Glu Val Lys Tyr 
        195                 200                 205             


Gln Asn Val Val His Gly Leu Cys Ser Asp Ala Cys Phe Ser Lys Phe 
    210                 215                 220                 


His Ser Thr Asn Asn Leu Thr Met Asn Cys Cys Glu Asn Cys Gly Ser 
225                 230                 235                 240 


Tyr Cys Tyr Ser Ser Ser Gly Pro Cys Gln Ser Gln Lys Val Phe Ser 
                245                 250                 255     


Ser Thr Ser Val Thr Ala Tyr Lys Gln Asn Ser Ala Gln Ile Pro Pro 
            260                 265                 270         


Tyr Ala Leu Gly Lys Ser Leu Arg Pro Ser Ala Glu Met Ile Glu Thr 
        275                 280                 285             


Thr Asn Asp Ser Gly Lys Thr Glu Leu Phe Cys Ser Ile Asn Cys Leu 
    290                 295                 300                 


Ser Ala Tyr Arg Val Lys Thr Val Thr Ser Ser Gly Val Gln Val Ser 
305                 310                 315                 320 


Cys His Ser Cys Lys Thr Ser Ala Ile Pro Gln Tyr His Leu Ala Met 
                325                 330                 335     


Ser Asn Gly Thr Ile Tyr Ser Phe Cys Ser Ser Ser Cys Val Val Ala 
            340                 345                 350         


Phe Gln Asn Val Phe Ser Lys Pro Lys Gly Thr Asn Ser Ser Ala Val 
        355                 360                 365             


Pro Leu Ser Gln Gly Gln Val Val Val Ser Pro Pro Ser Ser Arg Ser 
    370                 375                 380                 


Ala Val Ser Ile Gly Gly Gly Asn Thr Ser Ala Val Ser Pro Ser Ser 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ala Ala Ser Leu Gln Pro Leu Ala Glu Gln Ser 
                405                 410                 415     


Gln Gln Val Ala Leu Thr His Thr Val Val Lys Leu Lys Cys Gln His 
            420                 425                 430         


Cys Asn His Leu Phe Ala Thr Lys Pro Glu Leu Leu Phe Tyr Lys Gly 
        435                 440                 445             


Lys Met Phe Leu Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys Lys 
    450                 455                 460                 


Lys Asn Lys Val Val Ala Met Cys Asp Tyr Cys Lys Leu Gln Lys Ile 
465                 470                 475                 480 


Ile Lys Glu Thr Val Arg Phe Ser Gly Val Asp Lys Pro Phe Cys Ser 
                485                 490                 495     


Glu Val Cys Lys Phe Leu Ser Ala Arg Asp Phe Gly Glu Arg Trp Gly 
            500                 505                 510         


Asn Tyr Cys Lys Met Cys Ser Tyr Cys Ser Gln Thr Ser Pro Asn Leu 
        515                 520                 525             


Val Glu Asn Arg Leu Glu Gly Lys Leu Glu Glu Phe Cys Cys Glu Asp 
    530                 535                 540                 


Cys Met Ser Lys Phe Thr Val Leu Phe Tyr Gln Met Ala Lys Cys Asp 
545                 550                 555                 560 


Gly Cys Lys Arg Gln Gly Lys Leu Ser Glu Ser Ile Lys Trp Arg Gly 
                565                 570                 575     


Asn Ile Lys His Phe Cys Asn Leu Phe Cys Val Leu Glu Phe Cys His 
            580                 585                 590         


Gln Gln Ile Met Asn Asp Cys Leu Pro Gln Asn Lys Val Asn Ile Ser 
        595                 600                 605             


Lys Ala Lys Thr Ala Val Thr Glu Leu Pro Ser Ala Arg Thr Asp Thr 
    610                 615                 620                 


Thr Pro Val Ile Thr Ser Val Met Ser Leu Ala Lys Ile Pro Ala Thr 
625                 630                 635                 640 


Leu Ser Thr Gly Asn Thr Asn Ser Val Leu Lys Gly Ala Val Thr Lys 
                645                 650                 655     


Glu Ala Ala Lys Ile Ile Gln Asp Glu Ser Thr Gln Glu Asp Ala Met 
            660                 665                 670         


Lys Phe Pro Ser Ser Gln Ser Ser Gln Pro Ser Arg Leu Leu Lys Asn 
        675                 680                 685             


Lys Gly Ile Ser Cys Lys Pro Val Thr Gln Thr Lys Ala Thr Ser Cys 
    690                 695                 700                 


Lys Pro His Thr Gln His Lys Glu Cys Gln Thr Glu Cys Pro Val Arg 
705                 710                 715                 720 


Ala Val Cys 
            


<210>  5758
<211>  6238
<212>  DNA
<213>  Homosapiens

<400>  5758
ggcggctgcg gatatcgcct tagggacgcg ttgacattca ctggctagtc caccgctctc     60

agtcggagac cacattgcct cataagcctg aagaaaaaag aataagcctg agtatgtatt    120

ttaggtgtcc aactatccat taccaagaag aaatctattc gtttgagcct gagacactct    180

ttgaggtaaa aaattagaat gaaagaacct ttggatggtg aatgtggcaa agcagtggta    240

ccacagcagg agcttctgga caaaattaaa gaagaaccag acaatgctca agagtatgga    300

tgtgtccaac agccaaaaac tcaagaaagt aaattgaaaa ttggtggtgt gtcttcagtt    360

aatgagagac ctattgagac attttaaatc ctaaggatgt gatcacaact cgctttgaga    420

attcctatcc tagcaaagat ttctgcagcc aatcatgctt gtcatcttat gagctaaaga    480

aaaaacctgt tgttaccata tataccaaaa gcatttcaac taagtgcagt atgtgtcaga    540

agaatgctga tactcgattt gaagttaaat atcaaaatgt ggtacatggt ctttgtagtg    600

atgcctgttt ttcaaaattt cactctacaa acaacctcac catgaactgt tgtgagaact    660

gtgggagcta ttgctatagt agctctggtc cttgccaatc ccagaaggtt tttagttcaa    720

caagtgtcac ggcatacaag cagaattctg cccaaattcc tccatatgcc ctggggaagt    780

cattgaggcc ctcagctgaa atgattgaga ctacaaatga ttcaggaaaa acagagcttt    840

tctgctctat taattgctta tctgcttaca gagttaagac tgttacttct tcaggtgtcc    900

aggtttcatg tcatagttgt aaaacctcag caatccctca gtatcaccta gccatgtcaa    960

atggaactat atacagcttc tgcagctcca gttgtgtggt tgctttccag aatgtattta   1020

gcaagccaaa aggaacaaac tcttcggcgg tgcccctgtc tcagggccaa gtggttgtaa   1080

gcccgccctc ctccaggtca gcagtgtcaa taggaggagg taacacctct gccgtttccc   1140

ccagctccat ccgtggctct gctgcagcca gcctccaacc tcttgctgaa caatcccagc   1200

aagttgcttt aacccataca gttgttaaac tcaagtgtca gcactgtaac catctatttg   1260

ccacaaaacc agaacttctt ttttacaagg gtaaaatgtt tctgttttgt ggcaagaatt   1320

gctctgatga atacaagaag aaaaataaag ttgtggcaat gtgtgactac tgtaaactgc   1380

agaaaattat aaaggagact gtgcgattct caggggttga taagccattc tgtagtgaag   1440

tttgcaaatt cctctctgcc cgtgactttg gagaacgatg gggaaactac tgtaagatgt   1500

gcagctactg ttcacagaca tccccaaatt tggtagaaaa tcgattggag ggcaagttag   1560

aagagttttg ttgtgaagat tgtatgtcca aatttacagt tctgttttat cagatggcca   1620

agtgtgatgg ttgtaaacga cagggtaaac taagcgagtc cataaagtgg cgaggcaaca   1680

ttaaacattt ctgtaaccta ttttgtgtct tggagttttg tcatcagcaa attatgaatg   1740

actgtcttcc acaaaataaa gtaaatattt ctaaagcaaa aactgctgtg acggagctcc   1800

cttctgcaag gacagataca acaccagtta taaccagtgt gatgtcattg gcaaaaatac   1860

ctgctacctt atctacaggg aacactaaca gtgttttaaa aggtgcagtt actaaagagg   1920

cagcaaagat cattcaagat gaaagtacac aggaagatgc tatgaaattt ccatcttccc   1980

aatcttccca gccttccagg cttttaaaga acaaaggcat atcatgcaaa cccgtcacac   2040

agaccaaggc cacttcttgc aaaccacata cacagcacaa agaatgtcag acagagacgg   2100

gatttcacag tgttggcaac gctggtctca aactcgtgac ctcatgatgt gcccgcctca   2160

gcctcccaaa gtgctgggat tacaagcgtg agccaccgcg ccggcctatc atctattctt   2220

aagtattttg atacctgttg cctaaattgc cctcctgaaa agttacatca atgtatgctc   2280

caaccagcag tgttcaggag gatccatttc tctacaacct cactgacact gagtatcaaa   2340

attcagaaag gttgaatata cagtacagtc aatactagta tactcttcat ccagattaat   2400

gaaatgttaa ctttttgcaa tatttatttt cttttttttt ctggattgtt tgaaagtaaa   2460

acattatttt tctgtctctt tttcttcctt ttctttcttt tttttgagat ggagtttcac   2520

tcttgtctcc caggccggag tgcaatgaca tgatctcggc acattgcaac ctccgcctcc   2580

cgggttcaag cgattctcct gcctcagcct ctcaagtagc tgagattata ggcatgtacc   2640

accatgcctg gctaattttg tgtttttagt agagacgggg tttcaccacg ttggcctggc   2700

tggtctcgaa ctcctgacct caggtgatct gcccgccttg gcctcccaaa gtgctgggat   2760

tacaggtgtg agccccatgc ctggcctttt ttttcttttt ctttaaaaaa attttttgac   2820

accagtgtca ctcaccaata aaaaatttat tctttttgtt tttttttgag acgtagtctc   2880

aagagtgcag tggtgtgatc atggctctct gcaggctcaa cctcctgggc tcaggcaatc   2940

ctcttgcttt agctacccaa gtagctggga ctataggtgt gtgccattgc atccagccaa   3000

ttttttttct tcttcttttt ttttttttaa tgtagagatg gagtttcgcc atgttgcccg   3060

ggctggtctc taactccagg gctcaagtga cccacccacc ttggtgtccc aaagcactgg   3120

gattataggt gtgagccacc ctgctcagcc aaaaagttta ttgttaattt gatgtgtatc   3180

atggtcttca gccctaattt caataaccta ttgggtgctt gggattactt gtacatgtac   3240

cacatcctac agttttatta tacctagtga tcaagctttg ggcaaaggag aaattcagtt   3300

ttcagtagca tcattggaag tattatgact tgtgcttaaa cttttaccag tgcattcttt   3360

tgataaatag aaatagtaac aaaatatgaa ttttaaatat gtggggagat acataaagaa   3420

cattgcttat ttgttcttga aaataacagt gattcaaata tttcattcag atttacctat   3480

gcctaatgaa aaaaatgatg cagaacttga ttctccacct tcaaagaaaa aaagattagg   3540

ttttttccag acttatgata cagaatattt aaaagttggt tttattatct gtcctggatc   3600

aaaagaaagt tcaccaaggc cacagtgtgt catttgtgga gagatcttat ccagtgaaaa   3660

catgaagcca gcaaatcttt ctcatcattt gaagacaaaa cattcagaat tagaaaacaa   3720

accagtagat ttttttgaac aaaaatcttt agaaatggaa tgtcaaaata gttctttaaa   3780

aaagtgttta ctagttgaaa agtcacttgt gaaagcttct tatttaattg ctttccaaac   3840

tgctgcaagc aagaagccat tctccattgc tgaagaatta attaaaccat atttagtaga   3900

aatgtgttca gaagttttgg gttcaagtgc tggagacaaa atgaaaacta ttccactttc   3960

taatgttaca attcaacaca ggattgatga actatctgca gacattgaag accagctgat   4020

tcaaaaggtc agagagtcaa agtggtttgc ccttcagata gatgagtcat cagaaatctc   4080

aaatatcaca cttcttttgt gctatattcg tttcattgat tatgattgtc gtgatgtaaa   4140

agaagaatta ttattttgca ttgaaatgcc tactcaaata actggctttg aaatatttga   4200

actaataaat aaatatattg atagtaaatc tctgaattgg aaacattgtg ttggtctctg   4260

taccgatggg gctgcaagca tgactggcag gtattctggt ttaaaagcaa aaattcaaga   4320

agttgccatg aatacagcgg catttacaca ttgttttatt caccgtgaac gtttagtggc   4380

agaaaagttg tctccatgtt tacataaaat tcttttgcag tcagcacaaa ttttaagttt   4440

tataaagagc aatgcattaa attcacgtat gttaacaatt ttgtgtgaag agatgggatc   4500

tgagcatgtg agtttaccgc ttcatgctga agtacgttgg atatcaagag ggagaatgtt   4560

aaaaagatta tttgaattac gacatgagat tgaaatattt ttaagtcaaa agcattcaga   4620

tttggccaag tattttcatg atgaggaatg ggttggaaag ctggcctact tatcagatat   4680

attttcactt ataaatgaat taaatttaag tctccaagga actttgacta ctttcttcaa   4740

tttgtgtaat aaaattgatg tatttaagag aaagttaaaa atgtggttga agcgcacaca   4800

agagaatgat tatgacatgt tcccttcatt ttctgaattc tcaaattcat caggcttaaa   4860

tatgacagac atcacaagga ttatttttga gcacctggaa ggactttctc aagtgttcag   4920

tgactgtttt ccaccagaac aagacttgcg ttcaggaaat ttgtggataa ttcacccttt   4980

tatgaatcac caaaataata atctcaccga cttcgaagaa gaaaagctaa cagagctatc   5040

ttcagattta ggattacaag cactatttaa atcagtgtct gtaactcagt tttggataaa   5100

tgcaaagaca agttacccag aactccatga aagggcaatg aaatttttat tacccttttc   5160

aactgtttat ttatgtgatg ctgccttttc agctttgact gagtcaaaac aaaaaaatct   5220

gttgggttct ggccctgccc taagacttgc agtcacatct ttaattccaa ggatagaaaa   5280

attagtgaag gagaaagagt agcaatatgc acattgctta acagtgaagt caataatcct   5340

gtgttaagtt ttgtataagt atcctaaaag ataatttcct aatgtggatt tgtgttttca   5400

gtgattaaat gttttaataa tttttccctt tttgttgagg aatttaataa ttatgattgt   5460

tataaataat tatgtataat tataatctag ggtagaaaat ttagttattt cattaaattt   5520

ggactagtga caaagactgc aggtaatgag aagcccagtt tataatgtaa cagcacaacc   5580

tggatgttga aacagcttgg cctttagaag caagtggaac atttcagtct tctagccaac   5640

cagctactta cccctgcaag gttgtgagta ggtggaaaag atagatcttt tttttgagat   5700

ggagttttgc tcttgttgcc caggctggag tgcaatggcg tgatcttggc tcactggaac   5760

ctctgcctcc taggttcaaa caattctcct gcctcagcct tccaagtagc tggggttaca   5820

ggcatgtgcc accatgcccg tctattgtat tttttttagt agagacgggg tttcaccata   5880

ttggtcaggc tggtctctat ctcctgacct caagtgatcc acctgcctcg gcctcccaaa   5940

gtgctgggat tacaagtgtg agccaacgtg cccagctgga aaaagataga tctaagcagc   6000

ttgggtaact ataaatggaa gcagcagggg gatttgagac ccctgcttgg ggcctttctg   6060

gcccaatata ccagggctta gcaaactttt taaataaaga gccagatagt aaatattttc   6120

agctttgcag gccatactgt cacaactact caattctgca gttgcagtgc aaaagcagcc   6180

atagacaata tgcagataag tgtggctgtt tttaaataaa acttattcat gaacactg     6238


<210>  5759
<211>  538
<212>  PRT
<213>  Homosapiens

<400>  5759

Met Cys Gln Lys Asn Ala Asp Thr Arg Phe Glu Val Lys Tyr Gln Asn 
1               5                   10                  15      


Val Val His Gly Leu Cys Ser Asp Ala Cys Phe Ser Lys Phe His Ser 
            20                  25                  30          


Thr Asn Asn Leu Thr Met Asn Cys Cys Glu Asn Cys Gly Ser Tyr Cys 
        35                  40                  45              


Tyr Ser Ser Ser Gly Pro Cys Gln Ser Gln Lys Val Phe Ser Ser Thr 
    50                  55                  60                  


Ser Val Thr Ala Tyr Lys Gln Asn Ser Ala Gln Ile Pro Pro Tyr Ala 
65                  70                  75                  80  


Leu Gly Lys Ser Leu Arg Pro Ser Ala Glu Met Ile Glu Thr Thr Asn 
                85                  90                  95      


Asp Ser Gly Lys Thr Glu Leu Phe Cys Ser Ile Asn Cys Leu Ser Ala 
            100                 105                 110         


Tyr Arg Val Lys Thr Val Thr Ser Ser Gly Val Gln Val Ser Cys His 
        115                 120                 125             


Ser Cys Lys Thr Ser Ala Ile Pro Gln Tyr His Leu Ala Met Ser Asn 
    130                 135                 140                 


Gly Thr Ile Tyr Ser Phe Cys Ser Ser Ser Cys Val Val Ala Phe Gln 
145                 150                 155                 160 


Asn Val Phe Ser Lys Pro Lys Gly Thr Asn Ser Ser Ala Val Pro Leu 
                165                 170                 175     


Ser Gln Gly Gln Val Val Val Ser Pro Pro Ser Ser Arg Ser Ala Val 
            180                 185                 190         


Ser Ile Gly Gly Gly Asn Thr Ser Ala Val Ser Pro Ser Ser Ile Arg 
        195                 200                 205             


Gly Ser Ala Ala Ala Ser Leu Gln Pro Leu Ala Glu Gln Ser Gln Gln 
    210                 215                 220                 


Val Ala Leu Thr His Thr Val Val Lys Leu Lys Cys Gln His Cys Asn 
225                 230                 235                 240 


His Leu Phe Ala Thr Lys Pro Glu Leu Leu Phe Tyr Lys Gly Lys Met 
                245                 250                 255     


Phe Leu Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys Lys Lys Asn 
            260                 265                 270         


Lys Val Val Ala Met Cys Asp Tyr Cys Lys Leu Gln Lys Ile Ile Lys 
        275                 280                 285             


Glu Thr Val Arg Phe Ser Gly Val Asp Lys Pro Phe Cys Ser Glu Val 
    290                 295                 300                 


Cys Lys Phe Leu Ser Ala Arg Asp Phe Gly Glu Arg Trp Gly Asn Tyr 
305                 310                 315                 320 


Cys Lys Met Cys Ser Tyr Cys Ser Gln Thr Ser Pro Asn Leu Val Glu 
                325                 330                 335     


Asn Arg Leu Glu Gly Lys Leu Glu Glu Phe Cys Cys Glu Asp Cys Met 
            340                 345                 350         


Ser Lys Phe Thr Val Leu Phe Tyr Gln Met Ala Lys Cys Asp Gly Cys 
        355                 360                 365             


Lys Arg Gln Gly Lys Leu Ser Glu Ser Ile Lys Trp Arg Gly Asn Ile 
    370                 375                 380                 


Lys His Phe Cys Asn Leu Phe Cys Val Leu Glu Phe Cys His Gln Gln 
385                 390                 395                 400 


Ile Met Asn Asp Cys Leu Pro Gln Asn Lys Val Asn Ile Ser Lys Ala 
                405                 410                 415     


Lys Thr Ala Val Thr Glu Leu Pro Ser Ala Arg Thr Asp Thr Thr Pro 
            420                 425                 430         


Val Ile Thr Ser Val Met Ser Leu Ala Lys Ile Pro Ala Thr Leu Ser 
        435                 440                 445             


Thr Gly Asn Thr Asn Ser Val Leu Lys Gly Ala Val Thr Lys Glu Ala 
    450                 455                 460                 


Ala Lys Ile Ile Gln Asp Glu Ser Thr Gln Glu Asp Ala Met Lys Phe 
465                 470                 475                 480 


Pro Ser Ser Gln Ser Ser Gln Pro Ser Arg Leu Leu Lys Asn Lys Gly 
                485                 490                 495     


Ile Ser Cys Lys Pro Val Thr Gln Thr Lys Ala Thr Ser Cys Lys Pro 
            500                 505                 510         


His Thr Gln His Lys Glu Cys Gln Thr Glu Thr Gly Phe His Ser Val 
        515                 520                 525             


Gly Asn Ala Gly Leu Lys Leu Val Thr Ser 
    530                 535             


<210>  5760
<211>  971
<212>  DNA
<213>  Homosapiens

<400>  5760
aagtcaaaag cattcagatt tggccaagta ttttcatgat gaggaatggg ttggaaagct     60

ggcctactta tcagatatat tttcacttat aaatgaatta aatttaagtt ttctcaagtg    120

ttcagtgact gttttccacc agaacaagac ttgcgttcag gaaatttgtg gataattcac    180

ccttttatga atcaccaaaa taataatctc accgacttcg aagaagaaaa gctaacagag    240

ctatcttcag atttaggatt acaagcacta tttaaatcag tgtctgtaac tcagttttgg    300

ataaatgcaa agacaagtta cccagaactc catgaaaggg caatgaaatt tttattaccc    360

ttttcaactg tttatttatg tgatgctgcc ttttcagctt tgactgagtc aaaacaaaaa    420

aatctgttgg gttctggccc tgccctaaga cttgcagtca catctttaat tccaaggata    480

gaaaaattag tgaaggagaa agagtagcaa tatgcacatt gcttaacagt gaagtcaata    540

atcctgtgtt aagttttgta taagtatcct aaaagataat ttcctaatgt ggatttgtgt    600

tttcagtgat taaatgtttt aataattttt ccctttttgt tgaggaattt aataattatg    660

attgttataa ataattatgt ataattataa tctagggtag aaaatttagt tatttcatta    720

aatttggact agtgacaaag actgcaggta atgagaagcc cagtttataa tgtaacagca    780

caacctggat gttgaaacag cttggccttt agaagcaagt ggaacatttc agtcttctag    840

ccaaccagct acttacccct gcaaggttgt gagtaggtgg aaaagataga tctttttttt    900

gagatggagt tttgctcttg ttgcccaggc tggagtgcaa tggcgtgatc ttggctcact    960

ggaacctctg c                                                         971


<210>  5761
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  5761

Met Asn His Gln Asn Asn Asn Leu Thr Asp Phe Glu Glu Glu Lys Leu 
1               5                   10                  15      


Thr Glu Leu Ser Ser Asp Leu Gly Leu Gln Ala Leu Phe Lys Ser Val 
            20                  25                  30          


Ser Val Thr Gln Phe Trp Ile Asn Ala Lys Thr Ser Tyr Pro Glu Leu 
        35                  40                  45              


His Glu Arg Ala Met Lys Phe Leu Leu Pro Phe Ser Thr Val Tyr Leu 
    50                  55                  60                  


Cys Asp Ala Ala Phe Ser Ala Leu Thr Glu Ser Lys Gln Lys Asn Leu 
65                  70                  75                  80  


Leu Gly Ser Gly Pro Ala Leu Arg Leu Ala Val Thr Ser Leu Ile Pro 
                85                  90                  95      


Arg Ile Glu Lys Leu Val Lys Glu Lys Glu 
            100                 105     


<210>  5762
<211>  639
<212>  DNA
<213>  Homosapiens

<400>  5762
atatttttaa gtcaaaagca ttcagatttg gccaagtatt ttcatgatga ggaatgggtt     60

ggaaagctgg cctacttatc agatatattt tcacttataa atgaattaaa tttaagtttt    120

ctcaagtgtt cagtgactgt tttccaccag aacaagactt gcgttcagga aatttgtgga    180

taattcaccc ttttatgaat caccaaaata ataatctcac cgacttcgaa gaagaaaagc    240

taacagagct atcttcagat ttaggattac aagcactatt taaatcagtg tctgtaactc    300

agttttggat aaatgcaaag acaagttacc cagaactcca tgaaagggca atgaaatttt    360

tattaccctt ttcaactgtt tatttatgtg atgctgcctt ttcagctttg actgagtcaa    420

aacaaaaaaa tctgttgggt tctggccctg ccctaagact tgcagtcaca tctttaattc    480

caaggataga aaaattagtg aaggagaaag agtagcaata tgcacattgc ttaacagtga    540

agtcaataat cctgtgttaa gttttgtata agtatcctaa aagataattt cctaatgtgg    600

atttgtgttt tcagtgatta aatgttttaa taatttttc                           639


<210>  5763
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  5763

Met Asn His Gln Asn Asn Asn Leu Thr Asp Phe Glu Glu Glu Lys Leu 
1               5                   10                  15      


Thr Glu Leu Ser Ser Asp Leu Gly Leu Gln Ala Leu Phe Lys Ser Val 
            20                  25                  30          


Ser Val Thr Gln Phe Trp Ile Asn Ala Lys Thr Ser Tyr Pro Glu Leu 
        35                  40                  45              


His Glu Arg Ala Met Lys Phe Leu Leu Pro Phe Ser Thr Val Tyr Leu 
    50                  55                  60                  


Cys Asp Ala Ala Phe Ser Ala Leu Thr Glu Ser Lys Gln Lys Asn Leu 
65                  70                  75                  80  


Leu Gly Ser Gly Pro Ala Leu Arg Leu Ala Val Thr Ser Leu Ile Pro 
                85                  90                  95      


Arg Ile Glu Lys Leu Val Lys Glu Lys Glu 
            100                 105     


<210>  5764
<211>  3138
<212>  DNA
<213>  Homosapiens

<400>  5764
gagggcggag accaaggctg cgcaggcgtg gttggccggt cgttgcgttg ggatggatca     60

ggcggaattc cagaagagaa aataatccct gtctagatgc agaggacttg gttcctattc    120

cagtgctcct ccggtagcag ggaggcgaca gaaggtgtcc aactatccat taccaagaag    180

aaatctattc gtttgagcct gagacactct ttgaggtaaa aaattagaat gaaagaacct    240

ttggatggtg aatgtggcaa agcagtggta ccacagcagg agcttctgga caaaattaaa    300

gaagaaccag acaatgctca agagtatgga tgtgtccaac agccaaaaac tcaagaaagt    360

aaattgaaaa ttggtggtgt gtcttcagtt aatgagagac ctattgccca gcagttgaac    420

ccaggctttc agctttcttt tgcatcatct ggcccaagtg tgttgcttcc ttcagttcca    480

gctgttgcta ttaaggtttt ttgttctggt tgtaaaaaaa tgctttataa gggccaaact    540

gcatatcata agacaggatc tactcagctc ttctgctcca cacgatgcat caccagacat    600

tcttcacctg cctgcctgcc acctcctccc aagaaaacct gcacaaactg ctcgaaagac    660

attttaaatc ctaaggatgt gatcacaact cgctttgaga attcctatcc tagcaaagat    720

ttctgcagcc aatcatgctt gtcatcttat gagctaaaga aaaaacctgt tgttaccata    780

tataccaaaa gcatttcaac taagtgcagt atgtgtcaga agaatgctga tactcgattt    840

gaagttaaat atcaaaatgt ggtacatggt ctttgtagtg atgcctgttt ttcaaaattt    900

cactctacaa acaacctcac catgaactgt tgtgagaact gtgggagcta ttgctatagt    960

agctctggtc cttgccaatc ccagaaggtt tttagttcaa caagtgtcac ggcatacaag   1020

cagaattctg cccaaattcc tccatatgcc ctggggaagt cattgaggcc ctcagctgaa   1080

atgattgaga ctacaaatga ttcaggaaaa acagagcttt tctgctctat taattgctta   1140

tctgcttaca gagttaagac tgttacttct tcaggtgtcc aggtttcatg tcatagttgt   1200

aaaacctcag caatccctca gtatcaccta gccatgtcaa atggaactat atacagcttc   1260

tgcagctcca gttgtgtggt tgctttccag aatgtattta gcaagccaaa aggaacaaac   1320

tcttcggcgg tgcccctgtc tcagggccaa gtggttgtaa gcccgccctc ctccaggtca   1380

gcagtgtcaa taggaggagg taacacctct gccgtttccc ccagctccat ccgtggctct   1440

gctgcagcca gcctccaacc tcttgctgaa caatcccagc aagttgcttt aacccataca   1500

gttgttaaac tcaagtgtca gcactgtaac catctatttg ccacaaaacc agaacttctt   1560

ttttacaagg gtaaaatgtt tctgttttgt ggcaagaatt gctctgatga atacaagaag   1620

aaaaataaag ttgtggcaat gtgtgactac tgtaaactgc agaaaattat aaaggagact   1680

gtgcgattct caggggttga taagccattc tgtagtgaag tttgcaaatt cctctctgcc   1740

cgtgactttg gagaacgatg gggaaactac tgtaagatgt gcagctactg ttcacagaca   1800

tccccaaatt tggtagaaaa tcgattggag ggcaagttag aagagttttg ttgtgaagat   1860

tgtatgtcca aatttacagt tctgttttat cagatggcca agtgtgatgg ttgtaaacga   1920

cagggtaaac taagcgagtc cataaagtgg cgaggcaaca ttaaacattt ctgtaaccta   1980

ttttgtgtct tggagttttg tcatcagcaa attatgaatg actgtcttcc acaaaataaa   2040

gtaaatattt ctaaagcaaa aactgctgtg acggagctcc cttctgcaag gacagataca   2100

acaccagtta taaccagtgt gatgtcattg gcaaaaatac ctgctacctt atctacaggg   2160

aacactaaca gtgttttaaa aggtgcagtt actaaagagg cagcaaagat cattcaagat   2220

gaaagtacac aggaagatgc tatgaaattt ccatcttccc aatcttccca gccttccagg   2280

cttttaaaga acaaaggcat atcatgcaaa cccgtcacac agaccaaggc cacttcttgc   2340

aaaccacata cacagcacaa agaatgtcag acagatttac ctatgcctaa tgaaaaaaat   2400

gatgcagaac ttgattctcc accttcaaag aaaaaaagat taggtttttt ccagacttat   2460

gatacagaat atttaaaagt tggttttatt atctgtcctg gatcaaaaga aagttcacca   2520

aggccacagt gtgtcatttg tggagagatc ttatccagtg aaaacatgaa gccagcaaat   2580

ctttctcatc atttgaagac aaaacattca gaattagaaa acaaaccagt agattttttt   2640

gaacaaaaat ctttagaaat ggaatgtcaa aatagttctt taaaaaagtg tttactagtt   2700

gaaaagtcac ttgtgaaagc ttcttattta attgctttcc aaactgctgc aagcaagaag   2760

ccattctcca ttgctgaaga attaattaaa ccatatttag tagaaatgtg ttcagaagtt   2820

ttgggttcaa gtgctggaga caaaatgaaa actattccac tttctaatgt tacaattcaa   2880

cacaggattg atgaactatc tgcagacatt gaagaccagc tgattcaaaa ggtcagagag   2940

tcaaagtggt ttgcccttca gatagatgag tcatcagaaa tctcaaatat cacacttctt   3000

ttgtgctata ttcgtttcat tgattatgat tgtcgtgatg taaaagaaga attattattt   3060

tgcattgaaa tgcctactca aataactggc tttgaaatat ttgaactaat aaataaatat   3120

attgatagta aatctctg                                                 3138


<210>  5765
<211>  969
<212>  PRT
<213>  Homosapiens

<400>  5765

Met Lys Glu Pro Leu Asp Gly Glu Cys Gly Lys Ala Val Val Pro Gln 
1               5                   10                  15      


Gln Glu Leu Leu Asp Lys Ile Lys Glu Glu Pro Asp Asn Ala Gln Glu 
            20                  25                  30          


Tyr Gly Cys Val Gln Gln Pro Lys Thr Gln Glu Ser Lys Leu Lys Ile 
        35                  40                  45              


Gly Gly Val Ser Ser Val Asn Glu Arg Pro Ile Ala Gln Gln Leu Asn 
    50                  55                  60                  


Pro Gly Phe Gln Leu Ser Phe Ala Ser Ser Gly Pro Ser Val Leu Leu 
65                  70                  75                  80  


Pro Ser Val Pro Ala Val Ala Ile Lys Val Phe Cys Ser Gly Cys Lys 
                85                  90                  95      


Lys Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr 
            100                 105                 110         


Gln Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala 
        115                 120                 125             


Cys Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Asp 
    130                 135                 140                 


Ile Leu Asn Pro Lys Asp Val Ile Thr Thr Arg Phe Glu Asn Ser Tyr 
145                 150                 155                 160 


Pro Ser Lys Asp Phe Cys Ser Gln Ser Cys Leu Ser Ser Tyr Glu Leu 
                165                 170                 175     


Lys Lys Lys Pro Val Val Thr Ile Tyr Thr Lys Ser Ile Ser Thr Lys 
            180                 185                 190         


Cys Ser Met Cys Gln Lys Asn Ala Asp Thr Arg Phe Glu Val Lys Tyr 
        195                 200                 205             


Gln Asn Val Val His Gly Leu Cys Ser Asp Ala Cys Phe Ser Lys Phe 
    210                 215                 220                 


His Ser Thr Asn Asn Leu Thr Met Asn Cys Cys Glu Asn Cys Gly Ser 
225                 230                 235                 240 


Tyr Cys Tyr Ser Ser Ser Gly Pro Cys Gln Ser Gln Lys Val Phe Ser 
                245                 250                 255     


Ser Thr Ser Val Thr Ala Tyr Lys Gln Asn Ser Ala Gln Ile Pro Pro 
            260                 265                 270         


Tyr Ala Leu Gly Lys Ser Leu Arg Pro Ser Ala Glu Met Ile Glu Thr 
        275                 280                 285             


Thr Asn Asp Ser Gly Lys Thr Glu Leu Phe Cys Ser Ile Asn Cys Leu 
    290                 295                 300                 


Ser Ala Tyr Arg Val Lys Thr Val Thr Ser Ser Gly Val Gln Val Ser 
305                 310                 315                 320 


Cys His Ser Cys Lys Thr Ser Ala Ile Pro Gln Tyr His Leu Ala Met 
                325                 330                 335     


Ser Asn Gly Thr Ile Tyr Ser Phe Cys Ser Ser Ser Cys Val Val Ala 
            340                 345                 350         


Phe Gln Asn Val Phe Ser Lys Pro Lys Gly Thr Asn Ser Ser Ala Val 
        355                 360                 365             


Pro Leu Ser Gln Gly Gln Val Val Val Ser Pro Pro Ser Ser Arg Ser 
    370                 375                 380                 


Ala Val Ser Ile Gly Gly Gly Asn Thr Ser Ala Val Ser Pro Ser Ser 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ala Ala Ser Leu Gln Pro Leu Ala Glu Gln Ser 
                405                 410                 415     


Gln Gln Val Ala Leu Thr His Thr Val Val Lys Leu Lys Cys Gln His 
            420                 425                 430         


Cys Asn His Leu Phe Ala Thr Lys Pro Glu Leu Leu Phe Tyr Lys Gly 
        435                 440                 445             


Lys Met Phe Leu Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys Lys 
    450                 455                 460                 


Lys Asn Lys Val Val Ala Met Cys Asp Tyr Cys Lys Leu Gln Lys Ile 
465                 470                 475                 480 


Ile Lys Glu Thr Val Arg Phe Ser Gly Val Asp Lys Pro Phe Cys Ser 
                485                 490                 495     


Glu Val Cys Lys Phe Leu Ser Ala Arg Asp Phe Gly Glu Arg Trp Gly 
            500                 505                 510         


Asn Tyr Cys Lys Met Cys Ser Tyr Cys Ser Gln Thr Ser Pro Asn Leu 
        515                 520                 525             


Val Glu Asn Arg Leu Glu Gly Lys Leu Glu Glu Phe Cys Cys Glu Asp 
    530                 535                 540                 


Cys Met Ser Lys Phe Thr Val Leu Phe Tyr Gln Met Ala Lys Cys Asp 
545                 550                 555                 560 


Gly Cys Lys Arg Gln Gly Lys Leu Ser Glu Ser Ile Lys Trp Arg Gly 
                565                 570                 575     


Asn Ile Lys His Phe Cys Asn Leu Phe Cys Val Leu Glu Phe Cys His 
            580                 585                 590         


Gln Gln Ile Met Asn Asp Cys Leu Pro Gln Asn Lys Val Asn Ile Ser 
        595                 600                 605             


Lys Ala Lys Thr Ala Val Thr Glu Leu Pro Ser Ala Arg Thr Asp Thr 
    610                 615                 620                 


Thr Pro Val Ile Thr Ser Val Met Ser Leu Ala Lys Ile Pro Ala Thr 
625                 630                 635                 640 


Leu Ser Thr Gly Asn Thr Asn Ser Val Leu Lys Gly Ala Val Thr Lys 
                645                 650                 655     


Glu Ala Ala Lys Ile Ile Gln Asp Glu Ser Thr Gln Glu Asp Ala Met 
            660                 665                 670         


Lys Phe Pro Ser Ser Gln Ser Ser Gln Pro Ser Arg Leu Leu Lys Asn 
        675                 680                 685             


Lys Gly Ile Ser Cys Lys Pro Val Thr Gln Thr Lys Ala Thr Ser Cys 
    690                 695                 700                 


Lys Pro His Thr Gln His Lys Glu Cys Gln Thr Asp Leu Pro Met Pro 
705                 710                 715                 720 


Asn Glu Lys Asn Asp Ala Glu Leu Asp Ser Pro Pro Ser Lys Lys Lys 
                725                 730                 735     


Arg Leu Gly Phe Phe Gln Thr Tyr Asp Thr Glu Tyr Leu Lys Val Gly 
            740                 745                 750         


Phe Ile Ile Cys Pro Gly Ser Lys Glu Ser Ser Pro Arg Pro Gln Cys 
        755                 760                 765             


Val Ile Cys Gly Glu Ile Leu Ser Ser Glu Asn Met Lys Pro Ala Asn 
    770                 775                 780                 


Leu Ser His His Leu Lys Thr Lys His Ser Glu Leu Glu Asn Lys Pro 
785                 790                 795                 800 


Val Asp Phe Phe Glu Gln Lys Ser Leu Glu Met Glu Cys Gln Asn Ser 
                805                 810                 815     


Ser Leu Lys Lys Cys Leu Leu Val Glu Lys Ser Leu Val Lys Ala Ser 
            820                 825                 830         


Tyr Leu Ile Ala Phe Gln Thr Ala Ala Ser Lys Lys Pro Phe Ser Ile 
        835                 840                 845             


Ala Glu Glu Leu Ile Lys Pro Tyr Leu Val Glu Met Cys Ser Glu Val 
    850                 855                 860                 


Leu Gly Ser Ser Ala Gly Asp Lys Met Lys Thr Ile Pro Leu Ser Asn 
865                 870                 875                 880 


Val Thr Ile Gln His Arg Ile Asp Glu Leu Ser Ala Asp Ile Glu Asp 
                885                 890                 895     


Gln Leu Ile Gln Lys Val Arg Glu Ser Lys Trp Phe Ala Leu Gln Ile 
            900                 905                 910         


Asp Glu Ser Ser Glu Ile Ser Asn Ile Thr Leu Leu Leu Cys Tyr Ile 
        915                 920                 925             


Arg Phe Ile Asp Tyr Asp Cys Arg Asp Val Lys Glu Glu Leu Leu Phe 
    930                 935                 940                 


Cys Ile Glu Met Pro Thr Gln Ile Thr Gly Phe Glu Ile Phe Glu Leu 
945                 950                 955                 960 


Ile Asn Lys Tyr Ile Asp Ser Lys Ser 
                965                 


<210>  5766
<211>  499
<212>  DNA
<213>  Homosapiens

<400>  5766
gattggaggg caagttagaa gagttttgtt gtgaagattg tatgtccaaa tttacagttc     60

tgttttatca gatggccaag tgtgatggtt gtaaacgaca gggtaaacta agcgagtcca    120

taaagtggcg aggcaacatt aaacatttct gtaacctatt ttgtgtcttg gagttttgtc    180

atcagcaaat tatgaatgac tgtcttccac aaaataaagt aaatatttct aaagcaaaaa    240

ctgctgtgac ggagctccct tctgcaagga cagatacaac accagttata accagtgtga    300

tgtcattggc aaaaatacct gctaccttat ctacagggaa cactaacagt gttttaaaag    360

gtgcagttac taaagaggca gcaaagatca ttcaagatgt gagtttaatt gttaatactt    420

ttcttgataa tgccacttgg gcttattttc actttggata tggcattcta atatatctga    480

atacttttct ttttgctgg                                                 499


<210>  5767
<211>  151
<212>  PRT
<213>  Homosapiens

<400>  5767

Met Ser Lys Phe Thr Val Leu Phe Tyr Gln Met Ala Lys Cys Asp Gly 
1               5                   10                  15      


Cys Lys Arg Gln Gly Lys Leu Ser Glu Ser Ile Lys Trp Arg Gly Asn 
            20                  25                  30          


Ile Lys His Phe Cys Asn Leu Phe Cys Val Leu Glu Phe Cys His Gln 
        35                  40                  45              


Gln Ile Met Asn Asp Cys Leu Pro Gln Asn Lys Val Asn Ile Ser Lys 
    50                  55                  60                  


Ala Lys Thr Ala Val Thr Glu Leu Pro Ser Ala Arg Thr Asp Thr Thr 
65                  70                  75                  80  


Pro Val Ile Thr Ser Val Met Ser Leu Ala Lys Ile Pro Ala Thr Leu 
                85                  90                  95      


Ser Thr Gly Asn Thr Asn Ser Val Leu Lys Gly Ala Val Thr Lys Glu 
            100                 105                 110         


Ala Ala Lys Ile Ile Gln Asp Val Ser Leu Ile Val Asn Thr Phe Leu 
        115                 120                 125             


Asp Asn Ala Thr Trp Ala Tyr Phe His Phe Gly Tyr Gly Ile Leu Ile 
    130                 135                 140                 


Tyr Leu Asn Thr Phe Leu Phe 
145                 150     


<210>  5768
<211>  611
<212>  DNA
<213>  Homosapiens

<400>  5768
ccaaggtgtc caggtttcat gtcatagttg taaaacctca gcaatccctc agtatcacct     60

agccatgtca aatggaacta tatacagctt ctgcagctcc agttgtgtgg ttgctttcca    120

gaatgtattt agcaagccaa aaggaacaaa ctcttcggcg gtgcccctgt ctcagggcca    180

agtggttgta agcccgccct cctccaggtc agcagtgtca ataggaggag gtaacacctc    240

tgccgtttcc cccagctcca tccgtggctc tgctgcagcc agcctccaac ctcttgctga    300

acaatcccag caagttgctt taacccatac agttgttaaa ctcaagtgtc agcactgtaa    360

ccatctattt gccacaaaac cagaacttct tttttacaag gtaaagagag atcatgaaag    420

ggattgtata taaactcatc cagtagaaac acttttgtgt tttcaatttt gatcactcaa    480

tttgctttga catgaaaagg agttcttaaa gataaagcaa ctgtttagtt ggctcttaat    540

ggactgttgt ttctctgcag ggtaaaatgt ttctgttttg tggcaagaat tgctctgatg    600

aatacaagaa g                                                         611


<210>  5769
<211>  122
<212>  PRT
<213>  Homosapiens

<400>  5769

Met Ser Asn Gly Thr Ile Tyr Ser Phe Cys Ser Ser Ser Cys Val Val 
1               5                   10                  15      


Ala Phe Gln Asn Val Phe Ser Lys Pro Lys Gly Thr Asn Ser Ser Ala 
            20                  25                  30          


Val Pro Leu Ser Gln Gly Gln Val Val Val Ser Pro Pro Ser Ser Arg 
        35                  40                  45              


Ser Ala Val Ser Ile Gly Gly Gly Asn Thr Ser Ala Val Ser Pro Ser 
    50                  55                  60                  


Ser Ile Arg Gly Ser Ala Ala Ala Ser Leu Gln Pro Leu Ala Glu Gln 
65                  70                  75                  80  


Ser Gln Gln Val Ala Leu Thr His Thr Val Val Lys Leu Lys Cys Gln 
                85                  90                  95      


His Cys Asn His Leu Phe Ala Thr Lys Pro Glu Leu Leu Phe Tyr Lys 
            100                 105                 110         


Val Lys Arg Asp His Glu Arg Asp Cys Ile 
        115                 120         


<210>  5770
<211>  3022
<212>  DNA
<213>  Homosapiens

<400>  5770
agggacgcgt tgacattcac tggctagtcc accgctctca gtcggagacc acattgcctc     60

gaaggcgatt gtgaagcggg gctctgaggg gcttgatgcc ccccacccct cacacggaga    120

ccttgaaaga ggtgtccaac tatccattac caagaagaaa tctattcgtt tgagcctgag    180

acactctttg aggtaaaaaa ttagaatgaa agaacctttg gatggtgaat gtggcaaagc    240

agtggtacca cagcaggagc ttctggacaa aattaaagaa gaaccagaca atgctcaaga    300

gtatggatgt gtccaacagc caaaaactca agaaagtaaa ttgaaaattg gtggtgtgtc    360

ttcagttaat gagagaccta ttgcccagca gttgaaccca ggctttcagc tttcttttgc    420

atcatctggc ccaagtgtgt tgcttccttc agttccagct gttgctatta aggttttttg    480

ttctggttgt aaaaaaatgc tttataaggg ccaaactgca tatcataaga caggatctac    540

tcagctcttc tgctccacac gatgcatcac cagacattct tcacctgcct gcctgccacc    600

tcctcccaag aaaacctgca caaactgctc gaagtataaa attcttaaca tcccttttta    660

ctttaccttt tttttagtgt gtatattgtt tagttcaaac atactgttga tactttaaat    720

ctcttcagca tgtatctgta gaaataactt tttagttaat ggaagaattc accaatttta    780

aagttttgca acattaaata agtgacttgg tgttagaata ttgcctaaac cagttttcta    840

tcactttaaa ttttactatg gaaagaaata acaaatgaca tgtgggaatt gcaggactat    900

cctgtaattg tagacaccca ccatttaaat ttatttaaca gttatcttga aagctattgg    960

gtatagcata aaataatatc actcttttaa tagtatacaa aagctattta attctttaaa   1020

aagtaaaaac tctacatggt cgcaaaaatg tgtttatttc taatgtcctt gtggggtcat   1080

tgttgcttta caataatgct tagatgcaga gagaggaaaa aacagcaaca aagtcacata   1140

aatctttccc tgacttagta catttgaagg atttggcata ttttgcctat ttctgtggta   1200

gtgtaatttg aggaatacag tgtgttgtta atagtcacta caggcaaaaa acagtaagag   1260

cttgctttta aattgtggct ctgtcattta tctctgtgac ttcgggctag atgtttaact   1320

ttctaagcct ccatttctca tcagtaaata atagttgctt cctaggactt taatgagaca   1380

gtgttagcaa atggcctagc acatagcaag tacttaaaaa atggaatcct gttattatta   1440

ataataaaaa ttatatcgtg cgattattta taattaacat aaataaatat aataaatata   1500

tgtgtatata atacatatta ctatgtatac ttaacatatc acttgtaggc ccctattttg   1560

tctttggctg tgtttatctg ctttgtgtct tgacttaaac tatttaaaag tagatcctgc   1620

tatatggaaa tttccaagta aagaggagag aggatttttt tttttctttg ttgcccatgg   1680

tagagtgatc acagctcact gcagccttga actccccggg ctcagatgat cctcccacct   1740

cagcctttca aatagctggg accacaggcg cataccacca tgcccgacta atttttgtat   1800

ttttttgtag agatggtttt gctatgttgc ccaggctggt ctcaaactcc tgggctcaag   1860

caattagcct gcctcagcct cctaaagtgc tgggactatt ggtgtgagcc atcacatgtg   1920

gccaggagag aggaatttta aaatatttat atactctaaa ttagtttgtt gcaaaatacc   1980

attctaatta atgcttttat gtcattctca tgaaactaat ctgaaagagt aaacttagtt   2040

ttctattttt agatattgtt tcaacatacc aaataccaaa ataaaattaa ataattttaa   2100

agaacataac acaacttata catccaaatg cctattgttt tcttaaaagt agtcaccccc   2160

gtcagtgact ttttagcata aggttaggag acagattctt atcttttcag catgcatttg   2220

atttttacaa attttcaaag gctgcttgat accttaatca ggccaatata ttagctaatt   2280

aaattaagtc atactgttaa aacatgatat ttataaaatt aaaagttaaa aaatagtcta   2340

agggtttatc ttaagtttta tcttaaaaaa attagaaaaa tgttttgagc tatgttattg   2400

ttggaaggtg tggtttttct acggtaaatg ttacgatata acactcattt gcatgtgtaa   2460

ggttcagagt acacttataa tttatgtgca cagattttca ttataaagtc attctctttg   2520

atttacatat ttttacttgc tatttttgta cttattatgc cactggcaga ttcaccttat   2580

taagtgaaac tctttattgc tctgttttca gtagaaaaat cacttttcaa aattaatact   2640

tcatctgtgt ataagcatat tcttttggtt tctaagattt gctgtcatat ttttaaagtt   2700

gagttttaaa gaattaaaat aatttttgtt gttgttattt tctcatggtt taccattgaa   2760

tatacctgta taataaaggt gcaggatggg aggcaggata gtggaataat taattccata   2820

gactagaatc agattgcctg gattagtatt tcagctttat tgcctactag caatatgact   2880

ttgacaagct atttaacctc tcattcagtt tcctcatctg taaagtggca gttacagtaa   2940

tacttaacct tatagtggtt tggggatttt tttttttttt tgagacacgg tctcactctg   3000

tcacccaggc tggagtgcag tg                                            3022


<210>  5771
<211>  170
<212>  PRT
<213>  Homosapiens

<400>  5771

Met Lys Glu Pro Leu Asp Gly Glu Cys Gly Lys Ala Val Val Pro Gln 
1               5                   10                  15      


Gln Glu Leu Leu Asp Lys Ile Lys Glu Glu Pro Asp Asn Ala Gln Glu 
            20                  25                  30          


Tyr Gly Cys Val Gln Gln Pro Lys Thr Gln Glu Ser Lys Leu Lys Ile 
        35                  40                  45              


Gly Gly Val Ser Ser Val Asn Glu Arg Pro Ile Ala Gln Gln Leu Asn 
    50                  55                  60                  


Pro Gly Phe Gln Leu Ser Phe Ala Ser Ser Gly Pro Ser Val Leu Leu 
65                  70                  75                  80  


Pro Ser Val Pro Ala Val Ala Ile Lys Val Phe Cys Ser Gly Cys Lys 
                85                  90                  95      


Lys Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr 
            100                 105                 110         


Gln Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala 
        115                 120                 125             


Cys Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Tyr 
    130                 135                 140                 


Lys Ile Leu Asn Ile Pro Phe Tyr Phe Thr Phe Phe Leu Val Cys Ile 
145                 150                 155                 160 


Leu Phe Ser Ser Asn Ile Leu Leu Ile Leu 
                165                 170 


<210>  5772
<211>  2757
<212>  DNA
<213>  Homosapiens

<400>  5772
agtgctcctc cggtagcagg gaggcgacag aaggagtatg gatgtgtcca acagccaaaa     60

actcaagaaa gtaaattgaa aattggtggt gtgtcttcag ttaatgagag acctattgcc    120

cagcagttga acccaggctt tcagctttct tttgcatcat ctggcccaag tgtgttgctt    180

ccttcagttc cagctgttgc tattaaggtt ttttgttctg gttgtaaaaa aatgctttat    240

aagggccaaa ctgcatatca taagacagga tctactcagc tcttctgctc cacacgatgc    300

atcaccagac attcttcacc tgcctgcctg ccacctcctc ccaagaaaac ctgcacaaac    360

tgctcgaagt ataaaattct taacatccct ttttacttta cctttttttt agtgtgtata    420

ttgtttagtt caaacatact gttgatactt taaatctctt cagcatgtat ctgtagaaat    480

aactttttag ttaatggaag aattcaccaa ttttaaagtt ttgcaacatt aaataagtga    540

cttggtgtta gaatattgcc taaaccagtt ttctatcact ttaaatttta ctatggaaag    600

aaataacaaa tgacatgtgg gaattgcagg actatcctgt aattgtagac acccaccatt    660

taaatttatt taacagttat cttgaaagct attgggtata gcataaaata atatcactct    720

tttaatagta tacaaaagct atttaattct ttaaaaagta aaaactctac atggtcgcaa    780

aaatgtgttt atttctaatg tccttgtggg gtcattgttg ctttacaata atgcttagat    840

gcagagagag gaaaaaacag caacaaagtc acataaatct ttccctgact tagtacattt    900

gaaggatttg gcatattttg cctatttctg tggtagtgta atttgaggaa tacagtgtgt    960

tgttaatagt cactacaggc aaaaaacagt aagagcttgc ttttaaattg tggctctgtc   1020

atttatctct gtgacttcgg gctagatgtt taactttcta agcctccatt tctcatcagt   1080

aaataatagt tgcttcctag gactttaatg agacagtgtt agcaaatggc ctagcacata   1140

gcaagtactt aaaaaatgga atcctgttat tattaataat aaaaattata tcgtgcgatt   1200

atttataatt aacataaata aatataataa atatatgtgt atataataca tattactatg   1260

tatacttaac atatcacttg taggccccta ttttgtcttt ggctgtgttt atctgctttg   1320

tgtcttgact taaactattt aaaagtagat cctgctatat ggaaatttcc aagtaaagag   1380

gagagaggat tttttttttt ctttgttgcc catggtagag tgatcacagc tcactgcagc   1440

cttgaactcc ccgggctcag atgatcctcc cacctcagcc tttcaaatag ctgggaccac   1500

aggcgcatac caccatgccc gactaatttt tgtatttttt tgtagagatg gttttgctat   1560

gttgcccagg ctggtctcaa actcctgggc tcaagcaatt agcctgcctc agcctcctaa   1620

agtgctggga ctattggtgt gagccatcac atgtggccag gagagaggaa ttttaaaata   1680

tttatatact ctaaattagt ttgttgcaaa ataccattct aattaatgct tttatgtcat   1740

tctcatgaaa ctaatctgaa agagtaaact tagttttcta tttttagata ttgtttcaac   1800

ataccaaata ccaaaataaa attaaataat tttaaagaac ataacacaac ttatacatcc   1860

aaatgcctat tgttttctta aaagtagtca cccccgtcag tgacttttta gcataaggtt   1920

aggagacaga ttcttatctt ttcagcatgc atttgatttt tacaaatttt caaaggctgc   1980

ttgatacctt aatcaggcca atatattagc taattaaatt aagtcatact gttaaaacat   2040

gatatttata aaattaaaag ttaaaaaata gtctaagggt ttatcttaag ttttatctta   2100

aaaaaattag aaaaatgttt tgagctatgt tattgttgga aggtgtggtt tttctacggt   2160

aaatgttacg atataacact catttgcatg tgtaaggttc agagtacact tataatttat   2220

gtgcacagat tttcattata aagtcattct ctttgattta catattttta cttgctattt   2280

ttgtacttat tatgccactg gcagattcac cttattaagt gaaactcttt attgctctgt   2340

tttcagtaga aaaatcactt ttcaaaatta atacttcatc tgtgtataag catattcttt   2400

tggtttctaa gatttgctgt catattttta aagttgagtt ttaaagaatt aaaataattt   2460

ttgttgttgt tattttctca tggtttacca ttgaatatac ctgtataata aaggtgcagg   2520

atgggaggca ggatagtgga ataattaatt ccatagacta gaatcagatt gcctggatta   2580

gtatttcagc tttattgcct actagcaata tgactttgac aagctattta acctctcatt   2640

cagtttcctc atctgtaaag tggcagttac agtaatactt aaccttatag tggtttgggg   2700

attttttttt ttttttgaga cacggtctca ctctgtcacc caggctggag tgcagtg      2757


<210>  5773
<211>  73
<212>  PRT
<213>  Homosapiens

<400>  5773

Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr Gln 
1               5                   10                  15      


Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala Cys 
            20                  25                  30          


Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Tyr Lys 
        35                  40                  45              


Ile Leu Asn Ile Pro Phe Tyr Phe Thr Phe Phe Leu Val Cys Ile Leu 
    50                  55                  60                  


Phe Ser Ser Asn Ile Leu Leu Ile Leu 
65                  70              


<210>  5774
<211>  2765
<212>  DNA
<213>  Homosapiens

<400>  5774
gagggcggag accaaggctg cgcaggcgtg gttggccggt cgttgcgttg ggatggatca     60

ggcggaattc cagaagagaa aataatccct gtctagatgc agaggacttg gttcctattc    120

cagtgctcct ccggtagcag ggaggcgaca gaaggtgtcc aactatccat taccaagaag    180

aaatctattc gtttgagcct gagacactct ttgaggtaaa aaattagaat gaaagaacct    240

ttggatggtg aatgtggcaa agcagtggta ccacagcagg agcttctgga caaaattaaa    300

gaagaaccag acaatgctca agagtatgga tgtgtccaac agccaaaaac tcaagaaagt    360

aaattgaaaa ttggtggtgt gtcttcagtt aatgagagac ctattgccca gcagttgaac    420

ccaggctttc agctttcttt tgcatcatct ggcccaagtg tgttgcttcc ttcagttcca    480

gctgttgcta ttaaggtttt ttgttctggt tgtaaaaaaa tgctttataa gggccaaact    540

gcatatcata agacaggatc tactcagctc ttctgctcca cacgatgcat caccagacat    600

tcttcacctg cctgcctgcc acctcctccc aagaaaacct gcacaaactg ctcgaagtat    660

aaaattctta acatcccttt ttactttacc ttttttttag tgtgtatatt gtttagttca    720

aacatactgt tgatacttta aatctcttca gcatgtatct gtagaaataa ctttttagtt    780

aatggaagaa ttcaccaatt ttaaagtttt gcaacattaa ataagtgact tggtgttaga    840

atattgccta aaccagtttt ctatcacttt aaattttact atggaaagaa ataacaaatg    900

acatgtggga attgcaggac tatcctgtaa ttgtagacac ccaccattta aatttattta    960

acagttatct tgaaagctat tgggtatagc ataaaataat atcactcttt taatagtata   1020

caaaagctat ttaattcttt aaaaagtaaa aactctacat ggtcgcaaaa atgtgtttat   1080

ttctaatgtc cttgtggggt cattgttgct ttacaataat gcttagatgc agagagagga   1140

aaaaacagca acaaagtcac ataaatcttt ccctgactta gtacatttga aggatttggc   1200

atattttgcc tatttctgtg gtagtgtaat ttgaggaata cagtgtgttg ttaatagtca   1260

ctacaggcaa aaaacagtaa gagcttgctt ttaaattgtg gctctgtcat ttatctctgt   1320

gacttcgggc tagatgttta actttctaag cctccatttc tcatcagtaa ataatagttg   1380

cttcctagga ctttaatgag acagtgttag caaatggcct agcacatagc aagtacttaa   1440

aaaatggaat cctgttatta ttaataataa aaattatatc gtgcgattat ttataattaa   1500

cataaataaa tataataaat atatgtgtat ataatacata ttactatgta tacttaacat   1560

atcacttgta ggcccctatt ttgtctttgg ctgtgtttat ctgctttgtg tcttgactta   1620

aactatttaa aagtagatcc tgctatatgg aaatttccaa gtaaagagga gagaggattt   1680

ttttttttct ttgttgccca tggtagagtg atcacagctc actgcagcct tgaactcccc   1740

gggctcagat gatcctccca cctcagcctt tcaaatagct gggaccacag gcgcatacca   1800

ccatgcccga ctaatttttg tatttttttg tagagatggt tttgctatgt tgcccaggct   1860

ggtctcaaac tcctgggctc aagcaattag cctgcctcag cctcctaaag tgctgggact   1920

attggtgtga gccatcacat gtggccagga gagaggaatt ttaaaatatt tatatactct   1980

aaattagttt gttgcaaaat accattctaa ttaatgcttt tatgtcattc tcatgaaact   2040

aatctgaaag agtaaactta gttttctatt tttagatatt gtttcaacat accaaatacc   2100

aaaataaaat taaataattt taaagaacat aacacaactt atacatccaa atgcctattg   2160

ttttcttaaa agtagtcacc cccgtcagtg actttttagc ataaggttag gagacagatt   2220

cttatctttt cagcatgcat ttgattttta caaattttca aaggctgctt gataccttaa   2280

tcaggccaat atattagcta attaaattaa gtcatactgt taaaacatga tatttataaa   2340

attaaaagtt aaaaaatagt ctaagggttt atcttaagtt ttatcttaaa aaaattagaa   2400

aaatgttttg agctatgtta ttgttggaag gtgtggtttt tctacggtaa atgttacgat   2460

ataacactca tttgcatgtg taaggttcag agtacactta taatttatgt gcacagattt   2520

tcattataaa gtcattctct ttgatttaca tatttttact tgctattttt gtacttatta   2580

tgccactggc agattcacct tattaagtga aactctttat tgctctgttt tcagtagaaa   2640

aatcactttt caaaattaat acttcatctg tgtataagca tattcttttg gtttctaaga   2700

tttgctgtca tatttttaaa gttgagtttt aaagaattaa aataattttt gttgttgtta   2760

ttttc                                                               2765


<210>  5775
<211>  170
<212>  PRT
<213>  Homosapiens

<400>  5775

Met Lys Glu Pro Leu Asp Gly Glu Cys Gly Lys Ala Val Val Pro Gln 
1               5                   10                  15      


Gln Glu Leu Leu Asp Lys Ile Lys Glu Glu Pro Asp Asn Ala Gln Glu 
            20                  25                  30          


Tyr Gly Cys Val Gln Gln Pro Lys Thr Gln Glu Ser Lys Leu Lys Ile 
        35                  40                  45              


Gly Gly Val Ser Ser Val Asn Glu Arg Pro Ile Ala Gln Gln Leu Asn 
    50                  55                  60                  


Pro Gly Phe Gln Leu Ser Phe Ala Ser Ser Gly Pro Ser Val Leu Leu 
65                  70                  75                  80  


Pro Ser Val Pro Ala Val Ala Ile Lys Val Phe Cys Ser Gly Cys Lys 
                85                  90                  95      


Lys Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr 
            100                 105                 110         


Gln Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala 
        115                 120                 125             


Cys Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Tyr 
    130                 135                 140                 


Lys Ile Leu Asn Ile Pro Phe Tyr Phe Thr Phe Phe Leu Val Cys Ile 
145                 150                 155                 160 


Leu Phe Ser Ser Asn Ile Leu Leu Ile Leu 
                165                 170 


<210>  5776
<211>  2736
<212>  DNA
<213>  Homosapiens

<400>  5776
agggacgcgt tgacattcac tggctagtcc accgctctca gtcggagacc acattgcctc     60

gaaggcgatt gtgaagcggg gctctgaggg gcttgatgcc ccccacccct cacacggaga    120

ccttgaaaga ggtgtccaac tatccattac caagaagaaa tctattcgtt tgagcctgag    180

acactctttg aggtaaaaaa ttagaatgaa agaacctttg gatggtgaat gtggcaaagc    240

agtggtacca cagcaggagc ttctggacaa aattaaagaa gaaccagaca atgctcaaga    300

gtatggatgt gtccaacagc caaaaactca agaaagtaaa ttgaaaattg gtggtgtgtc    360

ttcagttaat gagagaccta ttgcccagca gttgaaccca ggctttcagc tttcttttgc    420

atcatctggc ccaagtgtgt tgcttccttc agttccagct gttgctatta aggttttttg    480

ttctggttgt aaaaaaatgc tttataaggg ccaaactgca tatcataaga caggatctac    540

tcagctcttc tgctccacac gatgcatcac cagacattct tcacctgcct gcctgccacc    600

tcctcccaag aaaacctgca caaactgctc gaagtataaa attcttaaca tcccttttta    660

ctttaccttt tttttagtgt gtatattgtt tagttcaaac atactgttga tactttaaat    720

ctcttcagca tgtatctgta gaaataactt tttagttaat ggaagaattc accaatttta    780

aagttttgca acattaaata agtgacttgg tgttagaata ttgcctaaac cagttttcta    840

tcactttaaa ttttactatg gaaagaaata acaaatgaca tgtgggaatt gcaggactat    900

cctgtaattg tagacaccca ccatttaaat ttatttaaca gttatcttga aagctattgg    960

gtatagcata aaataatatc actcttttaa tagtatacaa aagctattta attctttaaa   1020

aagtaaaaac tctacatggt cgcaaaaatg tgtttatttc taatgtcctt gtggggtcat   1080

tgttgcttta caataatgct tagatgcaga gagaggaaaa aacagcaaca aagtcacata   1140

aatctttccc tgacttagta catttgaagg atttggcata ttttgcctat ttctgtggta   1200

gtgtaatttg aggaatacag tgtgttgtta atagtcacta caggcaaaaa acagtaagag   1260

cttgctttta aattgtggct ctgtcattta tctctgtgac ttcgggctag atgtttaact   1320

ttctaagcct ccatttctca tcagtaaata atagttgctt cctaggactt taatgagaca   1380

gtgttagcaa atggcctagc acatagcaag tacttaaaaa atggaatcct gttattatta   1440

ataataaaaa ttatatcgtg cgattattta taattaacat aaataaatat aataaatata   1500

tgtgtatata atacatatta ctatgtatac ttaacatatc acttgtaggc ccctattttg   1560

tctttggctg tgtttatctg ctttgtgtct tgacttaaac tatttaaaag tagatcctgc   1620

tatatggaaa tttccaagta aagaggagag aggatttttt tttttctttg ttgcccatgg   1680

tagagtgatc acagctcact gcagccttga actccccggg ctcagatgat cctcccacct   1740

cagcctttca aatagctggg accacaggcg cataccacca tgcccgacta atttttgtat   1800

ttttttgtag agatggtttt gctatgttgc ccaggctggt ctcaaactcc tgggctcaag   1860

caattagcct gcctcagcct cctaaagtgc tgggactatt ggtgtgagcc atcacatgtg   1920

gccaggagag aggaatttta aaatatttat atactctaaa ttagtttgtt gcaaaatacc   1980

attctaatta atgcttttat gtcattctca tgaaactaat ctgaaagagt aaacttagtt   2040

ttctattttt agatattgtt tcaacatacc aaataccaaa ataaaattaa ataattttaa   2100

agaacataac acaacttata catccaaatg cctattgttt tcttaaaagt agtcaccccc   2160

gtcagtgact ttttagcata aggttaggag acagattctt atcttttcag catgcatttg   2220

atttttacaa attttcaaag gctgcttgat accttaatca ggccaatata ttagctaatt   2280

aaattaagtc atactgttaa aacatgatat ttataaaatt aaaagttaaa aaatagtcta   2340

agggtttatc ttaagtttta tcttaaaaaa attagaaaaa tgttttgagc tatgttattg   2400

ttggaaggtg tggtttttct acggtaaatg ttacgatata acactcattt gcatgtgtaa   2460

ggttcagagt acacttataa tttatgtgca cagattttca ttataaagtc attctctttg   2520

atttacatat ttttacttgc tatttttgta cttattatgc cactggcaga ttcaccttat   2580

taagtgaaac tctttattgc tctgttttca gtagaaaaat cacttttcaa aattaatact   2640

tcatctgtgt ataagcatat tcttttggtt tctaagattt gctgtcatat ttttaaagtt   2700

gagttttaaa gaattaaaat aatttttgtt gttgtt                             2736


<210>  5777
<211>  170
<212>  PRT
<213>  Homosapiens

<400>  5777

Met Lys Glu Pro Leu Asp Gly Glu Cys Gly Lys Ala Val Val Pro Gln 
1               5                   10                  15      


Gln Glu Leu Leu Asp Lys Ile Lys Glu Glu Pro Asp Asn Ala Gln Glu 
            20                  25                  30          


Tyr Gly Cys Val Gln Gln Pro Lys Thr Gln Glu Ser Lys Leu Lys Ile 
        35                  40                  45              


Gly Gly Val Ser Ser Val Asn Glu Arg Pro Ile Ala Gln Gln Leu Asn 
    50                  55                  60                  


Pro Gly Phe Gln Leu Ser Phe Ala Ser Ser Gly Pro Ser Val Leu Leu 
65                  70                  75                  80  


Pro Ser Val Pro Ala Val Ala Ile Lys Val Phe Cys Ser Gly Cys Lys 
                85                  90                  95      


Lys Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr 
            100                 105                 110         


Gln Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala 
        115                 120                 125             


Cys Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Tyr 
    130                 135                 140                 


Lys Ile Leu Asn Ile Pro Phe Tyr Phe Thr Phe Phe Leu Val Cys Ile 
145                 150                 155                 160 


Leu Phe Ser Ser Asn Ile Leu Leu Ile Leu 
                165                 170 


<210>  5778
<211>  2471
<212>  DNA
<213>  Homosapiens

<400>  5778
agtgctcctc cggtagcagg gaggcgacag aaggagtatg gatgtgtcca acagccaaaa     60

actcaagaaa gtaaattgaa aattggtggt gtgtcttcag ttaatgagag acctattgcc    120

cagcagttga acccaggctt tcagctttct tttgcatcat ctggcccaag tgtgttgctt    180

ccttcagttc cagctgttgc tattaaggtt ttttgttctg gttgtaaaaa aatgctttat    240

aagggccaaa ctgcatatca taagacagga tctactcagc tcttctgctc cacacgatgc    300

atcaccagac attcttcacc tgcctgcctg ccacctcctc ccaagaaaac ctgcacaaac    360

tgctcgaagt ataaaattct taacatccct ttttacttta cctttttttt agtgtgtata    420

ttgtttagtt caaacatact gttgatactt taaatctctt cagcatgtat ctgtagaaat    480

aactttttag ttaatggaag aattcaccaa ttttaaagtt ttgcaacatt aaataagtga    540

cttggtgtta gaatattgcc taaaccagtt ttctatcact ttaaatttta ctatggaaag    600

aaataacaaa tgacatgtgg gaattgcagg actatcctgt aattgtagac acccaccatt    660

taaatttatt taacagttat cttgaaagct attgggtata gcataaaata atatcactct    720

tttaatagta tacaaaagct atttaattct ttaaaaagta aaaactctac atggtcgcaa    780

aaatgtgttt atttctaatg tccttgtggg gtcattgttg ctttacaata atgcttagat    840

gcagagagag gaaaaaacag caacaaagtc acataaatct ttccctgact tagtacattt    900

gaaggatttg gcatattttg cctatttctg tggtagtgta atttgaggaa tacagtgtgt    960

tgttaatagt cactacaggc aaaaaacagt aagagcttgc ttttaaattg tggctctgtc   1020

atttatctct gtgacttcgg gctagatgtt taactttcta agcctccatt tctcatcagt   1080

aaataatagt tgcttcctag gactttaatg agacagtgtt agcaaatggc ctagcacata   1140

gcaagtactt aaaaaatgga atcctgttat tattaataat aaaaattata tcgtgcgatt   1200

atttataatt aacataaata aatataataa atatatgtgt atataataca tattactatg   1260

tatacttaac atatcacttg taggccccta ttttgtcttt ggctgtgttt atctgctttg   1320

tgtcttgact taaactattt aaaagtagat cctgctatat ggaaatttcc aagtaaagag   1380

gagagaggat tttttttttt ctttgttgcc catggtagag tgatcacagc tcactgcagc   1440

cttgaactcc ccgggctcag atgatcctcc cacctcagcc tttcaaatag ctgggaccac   1500

aggcgcatac caccatgccc gactaatttt tgtatttttt tgtagagatg gttttgctat   1560

gttgcccagg ctggtctcaa actcctgggc tcaagcaatt agcctgcctc agcctcctaa   1620

agtgctggga ctattggtgt gagccatcac atgtggccag gagagaggaa ttttaaaata   1680

tttatatact ctaaattagt ttgttgcaaa ataccattct aattaatgct tttatgtcat   1740

tctcatgaaa ctaatctgaa agagtaaact tagttttcta tttttagata ttgtttcaac   1800

ataccaaata ccaaaataaa attaaataat tttaaagaac ataacacaac ttatacatcc   1860

aaatgcctat tgttttctta aaagtagtca cccccgtcag tgacttttta gcataaggtt   1920

aggagacaga ttcttatctt ttcagcatgc atttgatttt tacaaatttt caaaggctgc   1980

ttgatacctt aatcaggcca atatattagc taattaaatt aagtcatact gttaaaacat   2040

gatatttata aaattaaaag ttaaaaaata gtctaagggt ttatcttaag ttttatctta   2100

aaaaaattag aaaaatgttt tgagctatgt tattgttgga aggtgtggtt tttctacggt   2160

aaatgttacg atataacact catttgcatg tgtaaggttc agagtacact tataatttat   2220

gtgcacagat tttcattata aagtcattct ctttgattta catattttta cttgctattt   2280

ttgtacttat tatgccactg gcagattcac cttattaagt gaaactcttt attgctctgt   2340

tttcagtaga aaaatcactt ttcaaaatta atacttcatc tgtgtataag catattcttt   2400

tggtttctaa gatttgctgt catattttta aagttgagtt ttaaagaatt aaaataattt   2460

ttgttgttgt t                                                        2471


<210>  5779
<211>  73
<212>  PRT
<213>  Homosapiens

<400>  5779

Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr Gln 
1               5                   10                  15      


Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala Cys 
            20                  25                  30          


Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Tyr Lys 
        35                  40                  45              


Ile Leu Asn Ile Pro Phe Tyr Phe Thr Phe Phe Leu Val Cys Ile Leu 
    50                  55                  60                  


Phe Ser Ser Asn Ile Leu Leu Ile Leu 
65                  70              


<210>  5780
<211>  654
<212>  DNA
<213>  Homosapiens

<400>  5780
ggggcggtgc caggtgggct acgcggctgg ggcggctgcg gatatcgcct tagggacgcg     60

ttgacattca ctggctagtc caccgctctc agtcggagac cacattgcct cgtgtccaac    120

tatccattac caagaagaaa tctattcgtt tgagcctgag acactctttg aggtaaaaaa    180

ttagaatgaa agaacctttg gatggtgaat gtggcaaagc agtggtacca cagcaggagc    240

ttctggacaa aattaaagaa gaaccagaca atgctcaaga gtatggatgt gtccaacagc    300

caaaaactca agaaagtaaa ttgaaaattg gtggtgtgtc ttcagttaat gagagaccta    360

ttgcccagca gttgaaccca ggctttcagc tttcttttgc atcatctggc ccaagtgtgt    420

tgcttccttc agttccagct gttgctatta aggttttttg ttctggttgt aaaaaaatgc    480

tttataaggg ccaaactgca tatcataaga caggatctac tcagctcttc tgctccacac    540

gatgcatcac cagacattct tcacctgcct gcctgccacc tcctcccaag aaaacctgca    600

caaactgctc gaagtataaa attcttaaca tcccttttta ctttaccttt tttt          654


<210>  5781
<211>  155
<212>  PRT
<213>  Homosapiens

<400>  5781

Met Lys Glu Pro Leu Asp Gly Glu Cys Gly Lys Ala Val Val Pro Gln 
1               5                   10                  15      


Gln Glu Leu Leu Asp Lys Ile Lys Glu Glu Pro Asp Asn Ala Gln Glu 
            20                  25                  30          


Tyr Gly Cys Val Gln Gln Pro Lys Thr Gln Glu Ser Lys Leu Lys Ile 
        35                  40                  45              


Gly Gly Val Ser Ser Val Asn Glu Arg Pro Ile Ala Gln Gln Leu Asn 
    50                  55                  60                  


Pro Gly Phe Gln Leu Ser Phe Ala Ser Ser Gly Pro Ser Val Leu Leu 
65                  70                  75                  80  


Pro Ser Val Pro Ala Val Ala Ile Lys Val Phe Cys Ser Gly Cys Lys 
                85                  90                  95      


Lys Met Leu Tyr Lys Gly Gln Thr Ala Tyr His Lys Thr Gly Ser Thr 
            100                 105                 110         


Gln Leu Phe Cys Ser Thr Arg Cys Ile Thr Arg His Ser Ser Pro Ala 
        115                 120                 125             


Cys Leu Pro Pro Pro Pro Lys Lys Thr Cys Thr Asn Cys Ser Lys Tyr 
    130                 135                 140                 


Lys Ile Leu Asn Ile Pro Phe Tyr Phe Thr Phe 
145                 150                 155 


<210>  5782
<211>  613
<212>  DNA
<213>  Homosapiens

<400>  5782
ggccggtcgt tgcgttggga tggatcaggc ggaattccag aagagaaaat aatccctgtc     60

tagatgcaga ggacttggtt cctattccag tgctcctccg gtagcaggga ggcgacagaa    120

ggtgtccaac tatccattac caagaagaaa tctattcgtt tgagcctgag acactctttg    180

aggtaaaaaa ttagaatgaa agaacctttg gatggtgaat gtggcaaagc agtggtacca    240

cagcaggagc ttctggacaa aattaaagaa gaaccagaca atgctcaagt aagcatttca    300

tcttcattta aaaatttaaa aaaattcctt cttttccatc tggtcaactg aaaaatttta    360

gttaaacggc ttctggtttg taagtttaaa ataacccaaa ctgagacagg ctctcgctgt    420

cgctgagggt gtagtgcagt ggtgcgatct ccttagctca ctgcagcctc cacctcccag    480

gctcaagtga tcttcccacc tcagcctcct gtgtagctgg gaccacaggg cacacaccaa    540

catgctcaac tatttttttg tatttttggt agagacgggg tttggccatg tttcccaggc    600

tggtctcaaa ctc                                                       613


<210>  5783
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5783

Met Gln Arg Thr Trp Phe Leu Phe Gln Cys Ser Ser Gly Ser Arg Glu 
1               5                   10                  15      


Ala Thr Glu Gly Val Gln Leu Ser Ile Thr Lys Lys Lys Ser Ile Arg 
            20                  25                  30          


Leu Ser Leu Arg His Ser Leu Arg 
        35                  40  


<210>  5784
<211>  1825
<212>  DNA
<213>  Homosapiens

<400>  5784
agcattctta taggagtctc cagcctctct ttgcagtttt caagacagga agttgacttc     60

ttccttgcag ctccttccac agtgaacaac ttggctgtca gagaggttct gattacaaaa    120

cccagtccag ccacaaaaag cttctgcaga agcctgccta atgtttacaa acctacgatg    180

cagccactac aattatcccc atttcaaggt cgaagaaatg gagatttata gaagttgtca    240

aatcgcttac tagcacacag ctaataagta gtaaagccat ctctcaaatc caggaaatct    300

aactgccctg cctgagctct gagtcaaggg tcctactttg gctgccagcc agcgacgact    360

tcaagggaat ctggaaactg ttcttcagga agaaacccat tagtttggaa ctggagaatt    420

cctttgcatc agatactaaa atgaaagaac cacttttagg tggtgagtgt gacaaggcag    480

tggcatcaca gctggggctg ctagatgaaa ttaagacaga acccgacaat gctcaagagt    540

attgtcatag gcaacagtcc agaactcagg agaatgaact gaaaataaat gctgtgtttt    600

cagagagtgc ttcacagttg actgcaggca ttcagctttc tctggcatca tctggcgtga    660

ataaaatgct tccttcagtt tcaaccacag ctattcaggt ttcctgtgct ggttgtaaaa    720

aaattctcca gaaggggcaa actgcttatc agaggaaagg atctgctcaa cttttctgct    780

ccataccatg catcactgaa tacatttcat ctgccagttc accagttcct tctaagagaa    840

cttgttcaaa ctgctcaaaa gacattttaa atccaaagga tgtgattagt gtccagctgg    900

aagacactac ctcttgcaaa actttttgca gcctatcttg tctttcatca tatgaagaaa    960

aaagaaaacc atttgttacc atatgtacta atagcatttt gaccaagtgc agcatgtgcc   1020

agaagactgc tattattcag tatgaagtaa aataccaaaa tgtgaaacat aatctttgca   1080

gtaatgcctg cctttcaaag tttcactctg ctaacaactt catcatgaac tgctgtgaga   1140

actgtggcac ttactgttac accagctcta gtctgtccca catacttcag atggaaggac   1200

agtctcatta ctttaatagt tcaaagagta ttacagcata taagcagaaa cctgccaaac   1260

cacttatatc tgttccttgc aaaccattga agccctcaga tgaaatgatt gagactacga   1320

gtgatttggg gaagacagag cttttctgct ctattaattg tttctctgca tacagtaaag   1380

ctaagatgga atcttcttca gtaagtgttg tttctgtggt gcatgatact tcaacagagc   1440

ttctttctcc aaagaaagat acgactccag ttataagcaa tatagtgtca ttggcagaca   1500

ccgatgttgc cttgcccatc atgaacactg atgtcttaca agatacagtt tcttcagtaa   1560

cagcaacagc agatgtcatt gtggatcttt ctaagagttc acctagtgaa cccagtaatg   1620

ctgttgctag tagtagtacg gaacagccaa gcgtttcacc atcttcatca gtattcagtc   1680

agcatgcaat tggttccagt acagaagtac aaaaagacaa tatgaaatct atgaaaataa   1740

gtgatgaact atgtcaccca aaatgtacat ccaaagtaca aaaagttaaa ggtaaatcac   1800

gaagtattaa aaaatcttgt tgtgc                                         1825


<210>  5785
<211>  460
<212>  PRT
<213>  Homosapiens

<400>  5785

Met Lys Glu Pro Leu Leu Gly Gly Glu Cys Asp Lys Ala Val Ala Ser 
1               5                   10                  15      


Gln Leu Gly Leu Leu Asp Glu Ile Lys Thr Glu Pro Asp Asn Ala Gln 
            20                  25                  30          


Glu Tyr Cys His Arg Gln Gln Ser Arg Thr Gln Glu Asn Glu Leu Lys 
        35                  40                  45              


Ile Asn Ala Val Phe Ser Glu Ser Ala Ser Gln Leu Thr Ala Gly Ile 
    50                  55                  60                  


Gln Leu Ser Leu Ala Ser Ser Gly Val Asn Lys Met Leu Pro Ser Val 
65                  70                  75                  80  


Ser Thr Thr Ala Ile Gln Val Ser Cys Ala Gly Cys Lys Lys Ile Leu 
                85                  90                  95      


Gln Lys Gly Gln Thr Ala Tyr Gln Arg Lys Gly Ser Ala Gln Leu Phe 
            100                 105                 110         


Cys Ser Ile Pro Cys Ile Thr Glu Tyr Ile Ser Ser Ala Ser Ser Pro 
        115                 120                 125             


Val Pro Ser Lys Arg Thr Cys Ser Asn Cys Ser Lys Asp Ile Leu Asn 
    130                 135                 140                 


Pro Lys Asp Val Ile Ser Val Gln Leu Glu Asp Thr Thr Ser Cys Lys 
145                 150                 155                 160 


Thr Phe Cys Ser Leu Ser Cys Leu Ser Ser Tyr Glu Glu Lys Arg Lys 
                165                 170                 175     


Pro Phe Val Thr Ile Cys Thr Asn Ser Ile Leu Thr Lys Cys Ser Met 
            180                 185                 190         


Cys Gln Lys Thr Ala Ile Ile Gln Tyr Glu Val Lys Tyr Gln Asn Val 
        195                 200                 205             


Lys His Asn Leu Cys Ser Asn Ala Cys Leu Ser Lys Phe His Ser Ala 
    210                 215                 220                 


Asn Asn Phe Ile Met Asn Cys Cys Glu Asn Cys Gly Thr Tyr Cys Tyr 
225                 230                 235                 240 


Thr Ser Ser Ser Leu Ser His Ile Leu Gln Met Glu Gly Gln Ser His 
                245                 250                 255     


Tyr Phe Asn Ser Ser Lys Ser Ile Thr Ala Tyr Lys Gln Lys Pro Ala 
            260                 265                 270         


Lys Pro Leu Ile Ser Val Pro Cys Lys Pro Leu Lys Pro Ser Asp Glu 
        275                 280                 285             


Met Ile Glu Thr Thr Ser Asp Leu Gly Lys Thr Glu Leu Phe Cys Ser 
    290                 295                 300                 


Ile Asn Cys Phe Ser Ala Tyr Ser Lys Ala Lys Met Glu Ser Ser Ser 
305                 310                 315                 320 


Val Ser Val Val Ser Val Val His Asp Thr Ser Thr Glu Leu Leu Ser 
                325                 330                 335     


Pro Lys Lys Asp Thr Thr Pro Val Ile Ser Asn Ile Val Ser Leu Ala 
            340                 345                 350         


Asp Thr Asp Val Ala Leu Pro Ile Met Asn Thr Asp Val Leu Gln Asp 
        355                 360                 365             


Thr Val Ser Ser Val Thr Ala Thr Ala Asp Val Ile Val Asp Leu Ser 
    370                 375                 380                 


Lys Ser Ser Pro Ser Glu Pro Ser Asn Ala Val Ala Ser Ser Ser Thr 
385                 390                 395                 400 


Glu Gln Pro Ser Val Ser Pro Ser Ser Ser Val Phe Ser Gln His Ala 
                405                 410                 415     


Ile Gly Ser Ser Thr Glu Val Gln Lys Asp Asn Met Lys Ser Met Lys 
            420                 425                 430         


Ile Ser Asp Glu Leu Cys His Pro Lys Cys Thr Ser Lys Val Gln Lys 
        435                 440                 445             


Val Lys Gly Lys Ser Arg Ser Ile Lys Lys Ser Cys 
    450                 455                 460 


<210>  5786
<211>  4177
<212>  DNA
<213>  Homosapiens

<400>  5786
ggggcggggt cggcggggcc gtttcgcttc gaagattgtt tcagaagcgt tgggcggggc     60

gtccctgaga gaaattagaa tctggaaact gttcttcagg aagaaaccca ttagtttgga    120

actggagaat tcctttgcat cagatactaa aatgaaagaa ccacttttag gtggtgagtg    180

tgacaaggca gtggcatcac agctggggct gctagatgaa attaagacag aacccgacaa    240

tgctcaagag tattgtcata ggcaacagtc cagaactcag gagaatgaac tgaaaataaa    300

tgctgtgttt tcagagagtg cttcacagtt gactgcaggc attcagcttt ctctggcatc    360

atctggcgtg aataaaatgc ttccttcagt ttcaaccaca gctattcagg tttcctgtgc    420

tggttgtaaa aaaattctcc agaaggggca aactgcttat cagaggaaag gatctgctca    480

acttttctgc tccataccat gcatcactga atacatttca tctgccagtt caccagttcc    540

ttctaagaga acttgttcaa actgctcaaa agacatttta aatccaaagg atgtgattag    600

tgtccagctg gaagacacta cctcttgcaa aactttttgc agcctatctt gtctttcatc    660

atatgaagaa aaaagaaaac catttgttac catatgtact aatagcattt tgaccaagtg    720

cagcatgtgc cagaagactg ctattattca gtatgaagta aaataccaaa atgtgaaaca    780

taatctttgc agtaatgcct gcctttcaaa gtttcactct gctaacaact tcatcatgaa    840

ctgctgtgag aactgtggca cttactgtta caccagctct agtctgtccc acatacttca    900

gatggaagga cagtctcatt actttaatag ttcaaagagt attacagcat ataagcagaa    960

acctgccaaa ccacttatat ctgttccttg caaaccattg aagccctcag atgaaatgat   1020

tgagactacg agtgatttgg ggaagacaga gcttttctgc tctattaatt gtttctctgc   1080

atacagtaaa gctaagatgg aatcttcttc agtaagtgtt gtttctgtgg tgcatgatac   1140

ttcaacagag cttctttctc caaagaaaga tacgactcca gttataagca atatagtgtc   1200

attggcagac accgatgttg ccttgcccat catgaacact gatgtcttac aagatacagt   1260

ttcttcagta acagcaacag cagatgtcat tgtggatctt tctaagagtt cacctagtga   1320

acccagtaat gctgttgcta gtagtagtac ggaacagcca agcgtttcac catcttcatc   1380

agtattcagt cagcatgcaa ttggttccag tacagaagta caaaaagaca atatgaaatc   1440

tatgaaaata agtgatgaac tatgtcaccc aaaatgtaca tccaaagtac aaaaagttaa   1500

aggtaaatca cgaagtatta aaaaatcttg ttgtgcagat tttgagtgtt tggaaaacag   1560

taaaaaagat gtggcattct gttattcatg ccagttgttc tgccaaaaat attttagctg   1620

tggaagagag tcatttgcaa cccacggaac ttctaattgg aaaaaaaccc tggaaaaatt   1680

cagaaagcat gaaaaaagtg aaatgcattt gaagtcattg gaattttgga gagaatacca   1740

attttgtgat ggagctgtca gtgacgattt atctattcat tcgaaacaga ttgagggaaa   1800

taaaaagtac ctaaagctta taattgaaaa tattttattt cttggaaagc agtgtttacc   1860

cttaagagga aacgaccagt cagtttcatc tgtgaataaa ggcaattttt tagaattgtt   1920

agaaatgaga gcaaaagata aaggagaaga aacatttcga cttatgaatt cacaagttga   1980

cttctataac agtacacaaa ttcaaagtga tattatcgaa ataataaaga ctgaaatgtt   2040

gcaggatatt gtgaatgaga tcaatgactc ctcagcattt tcaatcatat gtgatgagac   2100

aatcaatagt gccatgaaag aacagctttc aatttgtgta agatacccac aaaaatcatc   2160

aaaggctatc ttaattaagg aaagattctt gggttttgtt gatactgagg agatgactgg   2220

gacccactta cataggacta tcaaaactta tctgcagcaa attggagttg atatggataa   2280

aatacatggc caggcctatg atagcaccac taatttgaag ataaaattta ataaaatagc   2340

agcagaattc aagaaagaag aaccaagagc tttatacata cattgttatg cacacttttt   2400

ggatttatca ataattaggt tttgtaaaga agtaaaagaa ctccgaagtg ctctaaaaac   2460

tctcagttct ttgttcaaca ctatttgtat gtctggggaa atgttggcaa attttcgaaa   2520

catttatagg ctaagtcaaa acaaaacatg caagaaacat atatcacaat catgttggac   2580

agtccatgat cgtacattac tatctgtgat tgacagtctt ccagagatta ttgaaacatt   2640

ggaagttata gcaagccatt cttcaaatac aagtttcgcc gatgaattga gtcatttgct   2700

gacattggtt tccaaatttg aatttgtctt ttgtttgaaa ttcctgtatc gagtgctgag   2760

tgttacagga attctttcca aagagcttca aaataaaacc atagacattt tttctttgtc   2820

ttcaaaaata gaagcaattt tggaatgttt atcatctgaa agaaatgacg tatactttaa   2880

aacaatctgg gatggaacag aggaaatatg tcaaaaaata acctgtaaag gttttaaagt   2940

tgaaaaacct tctcttcaga aaagaagaaa aattcagaaa tcagtagatc ttggcaattc   3000

agataatatg ttttttccta cttcaacaga agaacaatat aaaattaata tctattacca   3060

aggattagat actatattac aaaatttaaa gttatgtttt tcggagtttg attattgcaa   3120

aataaagcaa atttcagaac tgttatttaa atggaatgaa ccattaaatg aaacaacagc   3180

aaaacatgtt caggaatttt ataaacttga tgaggacatt atcccagaac ttagatttta   3240

tcgacattat gcaaagctta actttgtcat agatgatagt tgcataaact tcgtcagtct   3300

cggctgtttg tttattcagc atggtcttca cagtaatatt ccttgtctct caaagctatt   3360

atatattgct ttgtcttggc caattacttc agcaagtact gagaactcat tttctaccct   3420

gcctcgtctt aagacatatt tatgtaatac catgggacaa gagaagctta ctggcccagc   3480

cctaatggct gttgagcagg agttggtaaa taaactaatg gagcctgaaa gactcaatga   3540

aattgtggaa aagtttatca gtcagatgaa agaaatataa tacatgctca tttgaactta   3600

cctaaaagac ttgtatttcc attgggatgt tttcatttca aaattgttca aaattcaaaa   3660

gacacagaac gataaacagt gaagtctcct tccctccttt agaactcatt ttctcttccc   3720

aaaaagtgtt atcttttcct taaatatccc tctagaggta tttttcctaa gtggtattgt   3780

acggtgtata ctgttcttca gcttgtcttc tctgtgtaac atatttttga gattgtccca   3840

tgtcgttaca tgaagagttt cttgattctt ggtctataat tgcagatgtt attgtatgaa   3900

tgtaccataa tatatttgag cagtccctgc tgacattttt ttcctaacct tttgctatta   3960

taaataatga ttcattttat aaccttttat ataggtcaca ttgcacatga gtgagtttac   4020

tgtaagctgg aaatctaaag ttagaattac taggttaaga tatgtgcatt tttacttttg   4080

atagatattg gcaagttgcc atctataagg attgtgccag tttacagtcc cacccacaat   4140

gcatgagagt gcctattaaa tctttgtaag tgttatc                            4177


<210>  5787
<211>  1142
<212>  PRT
<213>  Homosapiens

<400>  5787

Met Lys Glu Pro Leu Leu Gly Gly Glu Cys Asp Lys Ala Val Ala Ser 
1               5                   10                  15      


Gln Leu Gly Leu Leu Asp Glu Ile Lys Thr Glu Pro Asp Asn Ala Gln 
            20                  25                  30          


Glu Tyr Cys His Arg Gln Gln Ser Arg Thr Gln Glu Asn Glu Leu Lys 
        35                  40                  45              


Ile Asn Ala Val Phe Ser Glu Ser Ala Ser Gln Leu Thr Ala Gly Ile 
    50                  55                  60                  


Gln Leu Ser Leu Ala Ser Ser Gly Val Asn Lys Met Leu Pro Ser Val 
65                  70                  75                  80  


Ser Thr Thr Ala Ile Gln Val Ser Cys Ala Gly Cys Lys Lys Ile Leu 
                85                  90                  95      


Gln Lys Gly Gln Thr Ala Tyr Gln Arg Lys Gly Ser Ala Gln Leu Phe 
            100                 105                 110         


Cys Ser Ile Pro Cys Ile Thr Glu Tyr Ile Ser Ser Ala Ser Ser Pro 
        115                 120                 125             


Val Pro Ser Lys Arg Thr Cys Ser Asn Cys Ser Lys Asp Ile Leu Asn 
    130                 135                 140                 


Pro Lys Asp Val Ile Ser Val Gln Leu Glu Asp Thr Thr Ser Cys Lys 
145                 150                 155                 160 


Thr Phe Cys Ser Leu Ser Cys Leu Ser Ser Tyr Glu Glu Lys Arg Lys 
                165                 170                 175     


Pro Phe Val Thr Ile Cys Thr Asn Ser Ile Leu Thr Lys Cys Ser Met 
            180                 185                 190         


Cys Gln Lys Thr Ala Ile Ile Gln Tyr Glu Val Lys Tyr Gln Asn Val 
        195                 200                 205             


Lys His Asn Leu Cys Ser Asn Ala Cys Leu Ser Lys Phe His Ser Ala 
    210                 215                 220                 


Asn Asn Phe Ile Met Asn Cys Cys Glu Asn Cys Gly Thr Tyr Cys Tyr 
225                 230                 235                 240 


Thr Ser Ser Ser Leu Ser His Ile Leu Gln Met Glu Gly Gln Ser His 
                245                 250                 255     


Tyr Phe Asn Ser Ser Lys Ser Ile Thr Ala Tyr Lys Gln Lys Pro Ala 
            260                 265                 270         


Lys Pro Leu Ile Ser Val Pro Cys Lys Pro Leu Lys Pro Ser Asp Glu 
        275                 280                 285             


Met Ile Glu Thr Thr Ser Asp Leu Gly Lys Thr Glu Leu Phe Cys Ser 
    290                 295                 300                 


Ile Asn Cys Phe Ser Ala Tyr Ser Lys Ala Lys Met Glu Ser Ser Ser 
305                 310                 315                 320 


Val Ser Val Val Ser Val Val His Asp Thr Ser Thr Glu Leu Leu Ser 
                325                 330                 335     


Pro Lys Lys Asp Thr Thr Pro Val Ile Ser Asn Ile Val Ser Leu Ala 
            340                 345                 350         


Asp Thr Asp Val Ala Leu Pro Ile Met Asn Thr Asp Val Leu Gln Asp 
        355                 360                 365             


Thr Val Ser Ser Val Thr Ala Thr Ala Asp Val Ile Val Asp Leu Ser 
    370                 375                 380                 


Lys Ser Ser Pro Ser Glu Pro Ser Asn Ala Val Ala Ser Ser Ser Thr 
385                 390                 395                 400 


Glu Gln Pro Ser Val Ser Pro Ser Ser Ser Val Phe Ser Gln His Ala 
                405                 410                 415     


Ile Gly Ser Ser Thr Glu Val Gln Lys Asp Asn Met Lys Ser Met Lys 
            420                 425                 430         


Ile Ser Asp Glu Leu Cys His Pro Lys Cys Thr Ser Lys Val Gln Lys 
        435                 440                 445             


Val Lys Gly Lys Ser Arg Ser Ile Lys Lys Ser Cys Cys Ala Asp Phe 
    450                 455                 460                 


Glu Cys Leu Glu Asn Ser Lys Lys Asp Val Ala Phe Cys Tyr Ser Cys 
465                 470                 475                 480 


Gln Leu Phe Cys Gln Lys Tyr Phe Ser Cys Gly Arg Glu Ser Phe Ala 
                485                 490                 495     


Thr His Gly Thr Ser Asn Trp Lys Lys Thr Leu Glu Lys Phe Arg Lys 
            500                 505                 510         


His Glu Lys Ser Glu Met His Leu Lys Ser Leu Glu Phe Trp Arg Glu 
        515                 520                 525             


Tyr Gln Phe Cys Asp Gly Ala Val Ser Asp Asp Leu Ser Ile His Ser 
    530                 535                 540                 


Lys Gln Ile Glu Gly Asn Lys Lys Tyr Leu Lys Leu Ile Ile Glu Asn 
545                 550                 555                 560 


Ile Leu Phe Leu Gly Lys Gln Cys Leu Pro Leu Arg Gly Asn Asp Gln 
                565                 570                 575     


Ser Val Ser Ser Val Asn Lys Gly Asn Phe Leu Glu Leu Leu Glu Met 
            580                 585                 590         


Arg Ala Lys Asp Lys Gly Glu Glu Thr Phe Arg Leu Met Asn Ser Gln 
        595                 600                 605             


Val Asp Phe Tyr Asn Ser Thr Gln Ile Gln Ser Asp Ile Ile Glu Ile 
    610                 615                 620                 


Ile Lys Thr Glu Met Leu Gln Asp Ile Val Asn Glu Ile Asn Asp Ser 
625                 630                 635                 640 


Ser Ala Phe Ser Ile Ile Cys Asp Glu Thr Ile Asn Ser Ala Met Lys 
                645                 650                 655     


Glu Gln Leu Ser Ile Cys Val Arg Tyr Pro Gln Lys Ser Ser Lys Ala 
            660                 665                 670         


Ile Leu Ile Lys Glu Arg Phe Leu Gly Phe Val Asp Thr Glu Glu Met 
        675                 680                 685             


Thr Gly Thr His Leu His Arg Thr Ile Lys Thr Tyr Leu Gln Gln Ile 
    690                 695                 700                 


Gly Val Asp Met Asp Lys Ile His Gly Gln Ala Tyr Asp Ser Thr Thr 
705                 710                 715                 720 


Asn Leu Lys Ile Lys Phe Asn Lys Ile Ala Ala Glu Phe Lys Lys Glu 
                725                 730                 735     


Glu Pro Arg Ala Leu Tyr Ile His Cys Tyr Ala His Phe Leu Asp Leu 
            740                 745                 750         


Ser Ile Ile Arg Phe Cys Lys Glu Val Lys Glu Leu Arg Ser Ala Leu 
        755                 760                 765             


Lys Thr Leu Ser Ser Leu Phe Asn Thr Ile Cys Met Ser Gly Glu Met 
    770                 775                 780                 


Leu Ala Asn Phe Arg Asn Ile Tyr Arg Leu Ser Gln Asn Lys Thr Cys 
785                 790                 795                 800 


Lys Lys His Ile Ser Gln Ser Cys Trp Thr Val His Asp Arg Thr Leu 
                805                 810                 815     


Leu Ser Val Ile Asp Ser Leu Pro Glu Ile Ile Glu Thr Leu Glu Val 
            820                 825                 830         


Ile Ala Ser His Ser Ser Asn Thr Ser Phe Ala Asp Glu Leu Ser His 
        835                 840                 845             


Leu Leu Thr Leu Val Ser Lys Phe Glu Phe Val Phe Cys Leu Lys Phe 
    850                 855                 860                 


Leu Tyr Arg Val Leu Ser Val Thr Gly Ile Leu Ser Lys Glu Leu Gln 
865                 870                 875                 880 


Asn Lys Thr Ile Asp Ile Phe Ser Leu Ser Ser Lys Ile Glu Ala Ile 
                885                 890                 895     


Leu Glu Cys Leu Ser Ser Glu Arg Asn Asp Val Tyr Phe Lys Thr Ile 
            900                 905                 910         


Trp Asp Gly Thr Glu Glu Ile Cys Gln Lys Ile Thr Cys Lys Gly Phe 
        915                 920                 925             


Lys Val Glu Lys Pro Ser Leu Gln Lys Arg Arg Lys Ile Gln Lys Ser 
    930                 935                 940                 


Val Asp Leu Gly Asn Ser Asp Asn Met Phe Phe Pro Thr Ser Thr Glu 
945                 950                 955                 960 


Glu Gln Tyr Lys Ile Asn Ile Tyr Tyr Gln Gly Leu Asp Thr Ile Leu 
                965                 970                 975     


Gln Asn Leu Lys Leu Cys Phe Ser Glu Phe Asp Tyr Cys Lys Ile Lys 
            980                 985                 990         


Gln Ile Ser Glu Leu Leu Phe Lys  Trp Asn Glu Pro Leu  Asn Glu Thr 
        995                 1000                 1005             


Thr Ala  Lys His Val Gln Glu  Phe Tyr Lys Leu Asp  Glu Asp Ile 
    1010                 1015                 1020             


Ile Pro  Glu Leu Arg Phe Tyr  Arg His Tyr Ala Lys  Leu Asn Phe 
    1025                 1030                 1035             


Val Ile  Asp Asp Ser Cys Ile  Asn Phe Val Ser Leu  Gly Cys Leu 
    1040                 1045                 1050             


Phe Ile  Gln His Gly Leu His  Ser Asn Ile Pro Cys  Leu Ser Lys 
    1055                 1060                 1065             


Leu Leu  Tyr Ile Ala Leu Ser  Trp Pro Ile Thr Ser  Ala Ser Thr 
    1070                 1075                 1080             


Glu Asn  Ser Phe Ser Thr Leu  Pro Arg Leu Lys Thr  Tyr Leu Cys 
    1085                 1090                 1095             


Asn Thr  Met Gly Gln Glu Lys  Leu Thr Gly Pro Ala  Leu Met Ala 
    1100                 1105                 1110             


Val Glu  Gln Glu Leu Val Asn  Lys Leu Met Glu Pro  Glu Arg Leu 
    1115                 1120                 1125             


Asn Glu  Ile Val Glu Lys Phe  Ile Ser Gln Met Lys  Glu Ile 
    1130                 1135                 1140         


<210>  5788
<211>  4279
<212>  DNA
<213>  Homosapiens

<400>  5788
gtttcgcttc gaagattgtt tcagaagcgt tgggcggggc gtccctgaga gaaattaaca     60

cagtctcact ctgtcaccca ggctggagtg cagtggctca atgtccattc actgcgacct    120

ccacctccca ggttcaagcg attctcgtgc ctcagcctcc cgagtagctg ggattacagg    180

aatctggaaa ctgttcttca ggaagaaacc cattagtttg gaactggaga attcctttgc    240

atcagatact aaaatgaaag aaccactttt aggtggtgag tgtgacaagg cagtggcatc    300

acagctgggg ctgctagatg aaattaagac agaacccgac aatgctcaag agtattgtca    360

taggcaacag tccagaactc aggagaatga actgaaaata aatgctgtgt tttcagagag    420

tgcttcacag ttgactgcag gcattcagct ttctctggca tcatctggcg tgaataaaat    480

gcttccttca gtttcaacca cagctattca ggtttcctgt gctggttgta aaaaaattct    540

ccagaagggg caaactgctt atcagaggaa aggatctgct caacttttct gctccatacc    600

atgcatcact gaatacattt catctgccag ttcaccagtt ccttctaaga gaacttgttc    660

aaactgctca aaagacattt taaatccaaa ggatgtgatt agtgtccagc tggaagacac    720

tacctcttgc aaaacttttt gcagcctatc ttgtctttca tcatatgaag aaaaaagaaa    780

accatttgtt accatatgta ctaatagcat tttgaccaag tgcagcatgt gccagaagac    840

tgctattatt cagtatgaag taaaatacca aaatgtgaaa cataatcttt gcagtaatgc    900

ctgcctttca aagtttcact ctgctaacaa cttcatcatg aactgctgtg agaactgtgg    960

cacttactgt tacaccagct ctagtctgtc ccacatactt cagatggaag gacagtctca   1020

ttactttaat agttcaaaga gtattacagc atataagcag aaacctgcca aaccacttat   1080

atctgttcct tgcaaaccat tgaagccctc agatgaaatg attgagacta cgagtgattt   1140

ggggaagaca gagcttttct gctctattaa ttgtttctct gcatacagta aagctaagat   1200

ggaatcttct tcagtaagtg ttgtttctgt ggtgcatgat acttcaacag agcttctttc   1260

tccaaagaaa gatacgactc cagttataag caatatagtg tcattggcag acaccgatgt   1320

tgccttgccc atcatgaaca ctgatgtctt acaagataca gtttcttcag taacagcaac   1380

agcagatgtc attgtggatc tttctaagag ttcacctagt gaacccagta atgctgttgc   1440

tagtagtagt acggaacagc caagcgtttc accatcttca tcagtattca gtcagcatgc   1500

aattggttcc agtacagaag tacaaaaaga caatatgaaa tctatgaaaa taagtgatga   1560

actatgtcac ccaaaatgta catccaaagt acaaaaagtt aaaggtaaat cacgaagtat   1620

taaaaaatct tgttgtgcag attttgagtg tttggaaaac agtaaaaaag atgtggcatt   1680

ctgttattca tgccagttgt tctgccaaaa atattttagc tgtggaagag agtcatttgc   1740

aacccacgga acttctaatt ggaaaaaaac cctggaaaaa ttcagaaagc atgaaaaaag   1800

tgaaatgcat ttgaagtcat tggaattttg gagagaatac caattttgtg atggagctgt   1860

cagtgacgat ttatctattc attcgaaaca gattgaggga aataaaaagt acctaaagct   1920

tataattgaa aatattttat ttcttggaaa gcagtgttta cccttaagag gaaacgacca   1980

gtcagtttca tctgtgaata aaggcaattt tttagaattg ttagaaatga gagcaaaaga   2040

taaaggagaa gaaacatttc gacttatgaa ttcacaagtt gacttctata acagtacaca   2100

aattcaaagt gatattatcg aaataataaa gactgaaatg ttgcaggata ttgtgaatga   2160

gatcaatgac tcctcagcat tttcaatcat atgtgatgag acaatcaata gtgccatgaa   2220

agaacagctt tcaatttgtg taagataccc acaaaaatca tcaaaggcta tcttaattaa   2280

ggaaagattc ttgggttttg ttgatactga ggagatgact gggacccact tacataggac   2340

tatcaaaact tatctgcagc aaattggagt tgatatggat aaaatacatg gccaggccta   2400

tgatagcacc actaatttga agataaaatt taataaaata gcagcagaat tcaagaaaga   2460

agaaccaaga gctttataca tacattgtta tgcacacttt ttggatttat caataattag   2520

gttttgtaaa gaagtaaaag aactccgaag tgctctaaaa actctcagtt ctttgttcaa   2580

cactatttgt atgtctgggg aaatgttggc aaattttcga aacatttata ggctaagtca   2640

aaacaaaaca tgcaagaaac atatatcaca atcatgttgg acagtccatg atcgtacatt   2700

actatctgtg attgacagtc ttccagagat tattgaaaca ttggaagtta tagcaagcca   2760

ttcttcaaat acaagtttcg ccgatgaatt gagtcatttg ctgacattgg tttccaaatt   2820

tgaatttgtc ttttgtttga aattcctgta tcgagtgctg agtgttacag gaattctttc   2880

caaagagctt caaaataaaa ccatagacat tttttctttg tcttcaaaaa tagaagcaat   2940

tttggaatgt ttatcatctg aaagaaatga cgtatacttt aaaacaatct gggatggaac   3000

agaggaaata tgtcaaaaaa taacctgtaa aggttttaaa gttgaaaaac cttctcttca   3060

gaaaagaaga aaaattcaga aatcagtaga tcttggcaat tcagataata tgttttttcc   3120

tacttcaaca gaagaacaat ataaaattaa tatctattac caaggattag atactatatt   3180

acaaaattta aagttatgtt tttcggagtt tgattattgc aaaataaagc aaatttcaga   3240

actgttattt aaatggaatg aaccattaaa tgaaacaaca gcaaaacatg ttcaggaatt   3300

ttataaactt gatgaggaca ttatcccaga acttagattt tatcgacatt atgcaaagct   3360

taactttgtc atagatgata gttgcataaa cttcgtcagt ctcggctgtt tgtttattca   3420

gcatggtctt cacagtaata ttccttgtct ctcaaagcta ttatatattg ctttgtcttg   3480

gccaattact tcagcaagta ctgagaactc attttctacc ctgcctcgtc ttaagacata   3540

tttatgtaat accatgggac aagagaagct tactggccca gccctaatgg ctgttgagca   3600

ggagttggta aataaactaa tggagcctga aagactcaat gaaattgtgg aaaagtttat   3660

cagtcagatg aaagaaatat aatacatgct catttgaact tacctaaaag acttgtattt   3720

ccattgggat gttttcattt caaaattgtt caaaattcaa aagacacaga acgataaaca   3780

gtgaagtctc cttccctcct ttagaactca ttttctcttc ccaaaaagtg ttatcttttc   3840

cttaaatatc cctctagagg tatttttcct aagtggtatt gtacggtgta tactgttctt   3900

cagcttgtct tctctgtgta acatattttt gagattgtcc catgtcgtta catgaagagt   3960

ttcttgattc ttggtctata attgcagatg ttattgtatg aatgtaccat aatatatttg   4020

agcagtccct gctgacattt ttttcctaac cttttgctat tataaataat gattcatttt   4080

ataacctttt atataggtca cattgcacat gagtgagttt actgtaagct ggaaatctaa   4140

agttagaatt actaggttaa gatatgtgca tttttacttt tgatagatat tggcaagttg   4200

ccatctataa ggattgtgcc agtttacagt cccacccaca atgcatgaga gtgcctatta   4260

aatctttgta agtgttatc                                                4279


<210>  5789
<211>  1193
<212>  PRT
<213>  Homosapiens

<400>  5789

Met Ser Ile His Cys Asp Leu His Leu Pro Gly Ser Ser Asp Ser Arg 
1               5                   10                  15      


Ala Ser Ala Ser Arg Val Ala Gly Ile Thr Gly Ile Trp Lys Leu Phe 
            20                  25                  30          


Phe Arg Lys Lys Pro Ile Ser Leu Glu Leu Glu Asn Ser Phe Ala Ser 
        35                  40                  45              


Asp Thr Lys Met Lys Glu Pro Leu Leu Gly Gly Glu Cys Asp Lys Ala 
    50                  55                  60                  


Val Ala Ser Gln Leu Gly Leu Leu Asp Glu Ile Lys Thr Glu Pro Asp 
65                  70                  75                  80  


Asn Ala Gln Glu Tyr Cys His Arg Gln Gln Ser Arg Thr Gln Glu Asn 
                85                  90                  95      


Glu Leu Lys Ile Asn Ala Val Phe Ser Glu Ser Ala Ser Gln Leu Thr 
            100                 105                 110         


Ala Gly Ile Gln Leu Ser Leu Ala Ser Ser Gly Val Asn Lys Met Leu 
        115                 120                 125             


Pro Ser Val Ser Thr Thr Ala Ile Gln Val Ser Cys Ala Gly Cys Lys 
    130                 135                 140                 


Lys Ile Leu Gln Lys Gly Gln Thr Ala Tyr Gln Arg Lys Gly Ser Ala 
145                 150                 155                 160 


Gln Leu Phe Cys Ser Ile Pro Cys Ile Thr Glu Tyr Ile Ser Ser Ala 
                165                 170                 175     


Ser Ser Pro Val Pro Ser Lys Arg Thr Cys Ser Asn Cys Ser Lys Asp 
            180                 185                 190         


Ile Leu Asn Pro Lys Asp Val Ile Ser Val Gln Leu Glu Asp Thr Thr 
        195                 200                 205             


Ser Cys Lys Thr Phe Cys Ser Leu Ser Cys Leu Ser Ser Tyr Glu Glu 
    210                 215                 220                 


Lys Arg Lys Pro Phe Val Thr Ile Cys Thr Asn Ser Ile Leu Thr Lys 
225                 230                 235                 240 


Cys Ser Met Cys Gln Lys Thr Ala Ile Ile Gln Tyr Glu Val Lys Tyr 
                245                 250                 255     


Gln Asn Val Lys His Asn Leu Cys Ser Asn Ala Cys Leu Ser Lys Phe 
            260                 265                 270         


His Ser Ala Asn Asn Phe Ile Met Asn Cys Cys Glu Asn Cys Gly Thr 
        275                 280                 285             


Tyr Cys Tyr Thr Ser Ser Ser Leu Ser His Ile Leu Gln Met Glu Gly 
    290                 295                 300                 


Gln Ser His Tyr Phe Asn Ser Ser Lys Ser Ile Thr Ala Tyr Lys Gln 
305                 310                 315                 320 


Lys Pro Ala Lys Pro Leu Ile Ser Val Pro Cys Lys Pro Leu Lys Pro 
                325                 330                 335     


Ser Asp Glu Met Ile Glu Thr Thr Ser Asp Leu Gly Lys Thr Glu Leu 
            340                 345                 350         


Phe Cys Ser Ile Asn Cys Phe Ser Ala Tyr Ser Lys Ala Lys Met Glu 
        355                 360                 365             


Ser Ser Ser Val Ser Val Val Ser Val Val His Asp Thr Ser Thr Glu 
    370                 375                 380                 


Leu Leu Ser Pro Lys Lys Asp Thr Thr Pro Val Ile Ser Asn Ile Val 
385                 390                 395                 400 


Ser Leu Ala Asp Thr Asp Val Ala Leu Pro Ile Met Asn Thr Asp Val 
                405                 410                 415     


Leu Gln Asp Thr Val Ser Ser Val Thr Ala Thr Ala Asp Val Ile Val 
            420                 425                 430         


Asp Leu Ser Lys Ser Ser Pro Ser Glu Pro Ser Asn Ala Val Ala Ser 
        435                 440                 445             


Ser Ser Thr Glu Gln Pro Ser Val Ser Pro Ser Ser Ser Val Phe Ser 
    450                 455                 460                 


Gln His Ala Ile Gly Ser Ser Thr Glu Val Gln Lys Asp Asn Met Lys 
465                 470                 475                 480 


Ser Met Lys Ile Ser Asp Glu Leu Cys His Pro Lys Cys Thr Ser Lys 
                485                 490                 495     


Val Gln Lys Val Lys Gly Lys Ser Arg Ser Ile Lys Lys Ser Cys Cys 
            500                 505                 510         


Ala Asp Phe Glu Cys Leu Glu Asn Ser Lys Lys Asp Val Ala Phe Cys 
        515                 520                 525             


Tyr Ser Cys Gln Leu Phe Cys Gln Lys Tyr Phe Ser Cys Gly Arg Glu 
    530                 535                 540                 


Ser Phe Ala Thr His Gly Thr Ser Asn Trp Lys Lys Thr Leu Glu Lys 
545                 550                 555                 560 


Phe Arg Lys His Glu Lys Ser Glu Met His Leu Lys Ser Leu Glu Phe 
                565                 570                 575     


Trp Arg Glu Tyr Gln Phe Cys Asp Gly Ala Val Ser Asp Asp Leu Ser 
            580                 585                 590         


Ile His Ser Lys Gln Ile Glu Gly Asn Lys Lys Tyr Leu Lys Leu Ile 
        595                 600                 605             


Ile Glu Asn Ile Leu Phe Leu Gly Lys Gln Cys Leu Pro Leu Arg Gly 
    610                 615                 620                 


Asn Asp Gln Ser Val Ser Ser Val Asn Lys Gly Asn Phe Leu Glu Leu 
625                 630                 635                 640 


Leu Glu Met Arg Ala Lys Asp Lys Gly Glu Glu Thr Phe Arg Leu Met 
                645                 650                 655     


Asn Ser Gln Val Asp Phe Tyr Asn Ser Thr Gln Ile Gln Ser Asp Ile 
            660                 665                 670         


Ile Glu Ile Ile Lys Thr Glu Met Leu Gln Asp Ile Val Asn Glu Ile 
        675                 680                 685             


Asn Asp Ser Ser Ala Phe Ser Ile Ile Cys Asp Glu Thr Ile Asn Ser 
    690                 695                 700                 


Ala Met Lys Glu Gln Leu Ser Ile Cys Val Arg Tyr Pro Gln Lys Ser 
705                 710                 715                 720 


Ser Lys Ala Ile Leu Ile Lys Glu Arg Phe Leu Gly Phe Val Asp Thr 
                725                 730                 735     


Glu Glu Met Thr Gly Thr His Leu His Arg Thr Ile Lys Thr Tyr Leu 
            740                 745                 750         


Gln Gln Ile Gly Val Asp Met Asp Lys Ile His Gly Gln Ala Tyr Asp 
        755                 760                 765             


Ser Thr Thr Asn Leu Lys Ile Lys Phe Asn Lys Ile Ala Ala Glu Phe 
    770                 775                 780                 


Lys Lys Glu Glu Pro Arg Ala Leu Tyr Ile His Cys Tyr Ala His Phe 
785                 790                 795                 800 


Leu Asp Leu Ser Ile Ile Arg Phe Cys Lys Glu Val Lys Glu Leu Arg 
                805                 810                 815     


Ser Ala Leu Lys Thr Leu Ser Ser Leu Phe Asn Thr Ile Cys Met Ser 
            820                 825                 830         


Gly Glu Met Leu Ala Asn Phe Arg Asn Ile Tyr Arg Leu Ser Gln Asn 
        835                 840                 845             


Lys Thr Cys Lys Lys His Ile Ser Gln Ser Cys Trp Thr Val His Asp 
    850                 855                 860                 


Arg Thr Leu Leu Ser Val Ile Asp Ser Leu Pro Glu Ile Ile Glu Thr 
865                 870                 875                 880 


Leu Glu Val Ile Ala Ser His Ser Ser Asn Thr Ser Phe Ala Asp Glu 
                885                 890                 895     


Leu Ser His Leu Leu Thr Leu Val Ser Lys Phe Glu Phe Val Phe Cys 
            900                 905                 910         


Leu Lys Phe Leu Tyr Arg Val Leu Ser Val Thr Gly Ile Leu Ser Lys 
        915                 920                 925             


Glu Leu Gln Asn Lys Thr Ile Asp Ile Phe Ser Leu Ser Ser Lys Ile 
    930                 935                 940                 


Glu Ala Ile Leu Glu Cys Leu Ser Ser Glu Arg Asn Asp Val Tyr Phe 
945                 950                 955                 960 


Lys Thr Ile Trp Asp Gly Thr Glu Glu Ile Cys Gln Lys Ile Thr Cys 
                965                 970                 975     


Lys Gly Phe Lys Val Glu Lys Pro Ser Leu Gln Lys Arg Arg Lys Ile 
            980                 985                 990         


Gln Lys Ser Val Asp Leu Gly Asn  Ser Asp Asn Met Phe  Phe Pro Thr 
        995                 1000                 1005             


Ser Thr  Glu Glu Gln Tyr Lys  Ile Asn Ile Tyr Tyr  Gln Gly Leu 
    1010                 1015                 1020             


Asp Thr  Ile Leu Gln Asn Leu  Lys Leu Cys Phe Ser  Glu Phe Asp 
    1025                 1030                 1035             


Tyr Cys  Lys Ile Lys Gln Ile  Ser Glu Leu Leu Phe  Lys Trp Asn 
    1040                 1045                 1050             


Glu Pro  Leu Asn Glu Thr Thr  Ala Lys His Val Gln  Glu Phe Tyr 
    1055                 1060                 1065             


Lys Leu  Asp Glu Asp Ile Ile  Pro Glu Leu Arg Phe  Tyr Arg His 
    1070                 1075                 1080             


Tyr Ala  Lys Leu Asn Phe Val  Ile Asp Asp Ser Cys  Ile Asn Phe 
    1085                 1090                 1095             


Val Ser  Leu Gly Cys Leu Phe  Ile Gln His Gly Leu  His Ser Asn 
    1100                 1105                 1110             


Ile Pro  Cys Leu Ser Lys Leu  Leu Tyr Ile Ala Leu  Ser Trp Pro 
    1115                 1120                 1125             


Ile Thr  Ser Ala Ser Thr Glu  Asn Ser Phe Ser Thr  Leu Pro Arg 
    1130                 1135                 1140             


Leu Lys  Thr Tyr Leu Cys Asn  Thr Met Gly Gln Glu  Lys Leu Thr 
    1145                 1150                 1155             


Gly Pro  Ala Leu Met Ala Val  Glu Gln Glu Leu Val  Asn Lys Leu 
    1160                 1165                 1170             


Met Glu  Pro Glu Arg Leu Asn  Glu Ile Val Glu Lys  Phe Ile Ser 
    1175                 1180                 1185             


Gln Met  Lys Glu Ile 
    1190             


<210>  5790
<211>  501
<212>  DNA
<213>  Homosapiens

<400>  5790
tcgcttcgaa gattgtttca gaagcgttgg gcggggcgtc cctgagagaa attagaatct     60

ggaaactgtt cttcaggaag aaacccatta gtttggaact ggagaattcc tttgcatcag    120

atactaaaat gaaagaacca cttttaggtg gagtattgtc ataggcaaca gtccagaact    180

caggagaatg aactgaaaat aaatgctgtg ttttcagaga gtgcttcaca gttgactgca    240

ggcattcagc tttctctggc atcatctggc gtgaataaaa tgcttccttc agtttcaacc    300

acagctattc aggtttcctg tgctggttgt aaaaaaattc tccagaaggg gcaaactgct    360

tatcagagga aaggatctgc tcaacttttc tgctccatac catgcatcac tgaatacatt    420

tcatctgcca gttcaccagt tccttctaag agaacttgtt caaactgctc aaagtatata    480

attctaaatt atgccccctt t                                              501


<210>  5791
<211>  73
<212>  PRT
<213>  Homosapiens

<400>  5791

Met Leu Pro Ser Val Ser Thr Thr Ala Ile Gln Val Ser Cys Ala Gly 
1               5                   10                  15      


Cys Lys Lys Ile Leu Gln Lys Gly Gln Thr Ala Tyr Gln Arg Lys Gly 
            20                  25                  30          


Ser Ala Gln Leu Phe Cys Ser Ile Pro Cys Ile Thr Glu Tyr Ile Ser 
        35                  40                  45              


Ser Ala Ser Ser Pro Val Pro Ser Lys Arg Thr Cys Ser Asn Cys Ser 
    50                  55                  60                  


Lys Tyr Ile Ile Leu Asn Tyr Ala Pro 
65                  70              


<210>  5792
<211>  529
<212>  DNA
<213>  Homosapiens

<400>  5792
gcttcgaaga ttgtttcaga agcgttgggc ggggcgtccc tgagagaaat tagagtattg     60

tcataggcaa cagtccagaa ctcaggagaa tgaactgaaa ataaatgctg tgttttcaga    120

gagtgcttca cagttgactg caggcattca gctttctctg gcatcatctg gcgtgaataa    180

aatgcttcct tcagtttcaa ccacagctat tcaggtttcc tgtgctggtt gtaaaaaaat    240

tctccagaag gggcaaactg cttatcagag gaaaggatct gctcaacttt tctgctccat    300

accatgcatc actgaataca tttcatctgc cagttcacca gttccttcta agagaacttg    360

ttcaaactgc tcaaaaaacc tgccaaacca cttatatctg ttccttgcaa accattgaag    420

ccctcagatg aaatgattga gactacgagt gatttgggga agacagagct tttctgctct    480

attaattgtt tctctgcata cagtaaagct aagatggaat cttcttcag                529


<210>  5793
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  5793

Met Leu Pro Ser Val Ser Thr Thr Ala Ile Gln Val Ser Cys Ala Gly 
1               5                   10                  15      


Cys Lys Lys Ile Leu Gln Lys Gly Gln Thr Ala Tyr Gln Arg Lys Gly 
            20                  25                  30          


Ser Ala Gln Leu Phe Cys Ser Ile Pro Cys Ile Thr Glu Tyr Ile Ser 
        35                  40                  45              


Ser Ala Ser Ser Pro Val Pro Ser Lys Arg Thr Cys Ser Asn Cys Ser 
    50                  55                  60                  


Lys Asn Leu Pro Asn His Leu Tyr Leu Phe Leu Ala Asn His 
65                  70                  75              


<210>  5794
<211>  4200
<212>  DNA
<213>  Homosapiens

<400>  5794
gcttcgaaga ttgtttcaga agcgttgggc ggggcgtccc tgagagaaat tagttcaagc     60

gattctcgtg cctcagcctc ccgagtagct gggattacag gaatctggaa actgttcttc    120

aggaagaaac ccattagttt ggaactggag aattcctttg catcagatac taaaatgaaa    180

gaaccacttt taggtggtga gtgtgacaag gcagtggcat cacagctggg gctgctagat    240

gaaattaaga cagaacccga caatgctcaa gagtattgtc ataggcaaca gtccagaact    300

caggagaatg aactgaaaat aaatgctgtg ttttcagaga gtgcttcaca gttgactgca    360

ggcattcagc tttctctggc atcatctggc gtgaataaaa tgcttccttc agtttcaacc    420

acagctattc aggtttcctg tgctggttgt aaaaaaattc tccagaaggg gcaaactgct    480

tatcagagga aaggatctgc tcaacttttc tgctccatac catgcatcac tgaatacatt    540

tcatctgcca gttcaccagt tccttctaag agaacttgtt caaactgctc aaaagacatt    600

ttaaatccaa aggatgtgat tagtgtccag ctggaagaca ctacctcttg caaaactttt    660

tgcagcctat cttgtctttc atcatatgaa gaaaaaagaa aaccatttgt taccatatgt    720

actaatagca ttttgaccaa gtgcagcatg tgccagaaga ctgctattat tcagtatgaa    780

gtaaaatacc aaaatgtgaa acataatctt tgcagtaatg cctgcctttc aaagtttcac    840

tctgctaaca acttcatcat gaactgctgt gagaactgtg gcacttactg ttacaccagc    900

tctagtctgt cccacatact tcagatggaa ggacagtctc attactttaa tagttcaaag    960

agtattacag catataagca gaaacctgcc aaaccactta tatctgttcc ttgcaaacca   1020

ttgaagccct cagatgaaat gattgagact acgagtgatt tggggaagac agagcttttc   1080

tgctctatta attgtttctc tgcatacagt aaagctaaga tggaatcttc ttcagtaagt   1140

gttgtttctg tggtgcatga tacttcaaca gagcttcttt ctccaaagaa agatacgact   1200

ccagttataa gcaatatagt gtcattggca gacaccgatg ttgccttgcc catcatgaac   1260

actgatgtct tacaagatac agtttcttca gtaacagcaa cagcagatgt cattgtggat   1320

ctttctaaga gttcacctag tgaacccagt aatgctgttg ctagtagtag tacggaacag   1380

ccaagcgttt caccatcttc atcagtattc agtcagcatg caattggttc cagtacagaa   1440

gtacaaaaag acaatatgaa atctatgaaa ataagtgatg aactatgtca cccaaaatgt   1500

acatccaaag tacaaaaagt taaaggtaaa tcacgaagta ttaaaaaatc ttgttgtgca   1560

gattttgagt gtttggaaaa cagtaaaaaa gatgtggcat tctgttattc atgccagttg   1620

ttctgccaaa aatattttag ctgtggaaga gagtcatttg caacccacgg aacttctaat   1680

tggaaaaaaa ccctggaaaa attcagaaag catgaaaaaa gtgaaatgca tttgaagtca   1740

ttggaatttt ggagagaata ccaattttgt gatggagctg tcagtgacga tttatctatt   1800

cattcgaaac agattgaggg aaataaaaag tacctaaagc ttataattga aaatatttta   1860

tttcttggaa agcagtgttt acccttaaga ggaaacgacc agtcagtttc atctgtgaat   1920

aaaggcaatt ttttagaatt gttagaaatg agagcaaaag ataaaggaga agaaacattt   1980

cgacttatga attcacaagt tgacttctat aacagtacac aaattcaaag tgatattatc   2040

gaaataataa agactgaaat gttgcaggat attgtgaatg agatcaatga ctcctcagca   2100

ttttcaatca tatgtgatga gacaatcaat agtgccatga aagaacagct ttcaatttgt   2160

gtaagatacc cacaaaaatc atcaaaggct atcttaatta aggaaagatt cttgggtttt   2220

gttgatactg aggagatgac tgggacccac ttacatagga ctatcaaaac ttatctgcag   2280

caaattggag ttgatatgga taaaatacat ggccaggcct atgatagcac cactaatttg   2340

aagataaaat ttaataaaat agcagcagaa ttcaagaaag aagaaccaag agctttatac   2400

atacattgtt atgcacactt tttggattta tcaataatta ggttttgtaa agaagtaaaa   2460

gaactccgaa gtgctctaaa aactctcagt tctttgttca acactatttg tatgtctggg   2520

gaaatgttgg caaattttcg aaacatttat aggctaagtc aaaacaaaac atgcaagaaa   2580

catatatcac aatcatgttg gacagtccat gatcgtacat tactatctgt gattgacagt   2640

cttccagaga ttattgaaac attggaagtt atagcaagcc attcttcaaa tacaagtttc   2700

gccgatgaat tgagtcattt gctgacattg gtttccaaat ttgaatttgt cttttgtttg   2760

aaattcctgt atcgagtgct gagtgttaca ggaattcttt ccaaagagct tcaaaataaa   2820

accatagaca ttttttcttt gtcttcaaaa atagaagcaa ttttggaatg tttatcatct   2880

gaaagaaatg acgtatactt taaaacaatc tgggatggaa cagaggaaat atgtcaaaaa   2940

ataacctgta aaggttttaa agttgaaaaa ccttctcttc agaaaagaag aaaaattcag   3000

aaatcagtag atcttggcaa ttcagataat atgttttttc ctacttcaac agaagaacaa   3060

tataaaatta atatctatta ccaaggatta gatactatat tacaaaattt aaagttatgt   3120

ttttcggagt ttgattattg caaaataaag caaatttcag aactgttatt taaatggaat   3180

gaaccattaa atgaaacaac agcaaaacat gttcaggaat tttataaact tgatgaggac   3240

attatcccag aacttagatt ttatcgacat tatgcaaagc ttaactttgt catagatgat   3300

agttgcataa acttcgtcag tctcggctgt ttgtttattc agcatggtct tcacagtaat   3360

attccttgtc tctcaaagct attatatatt gctttgtctt ggccaattac ttcagcaagt   3420

actgagaact cattttctac cctgcctcgt cttaagacat atttatgtaa taccatggga   3480

caagagaagc ttactggccc agccctaatg gctgttgagc aggagttggt aaataaacta   3540

atggagcctg aaagactcaa tgaaattgtg gaaaagttta tcagtcagat gaaagaaata   3600

taatacatgc tcatttgaac ttacctaaaa gacttgtatt tccattggga tgttttcatt   3660

tcaaaattgt tcaaaattca aaagacacag aacgataaac agtgaagtct ccttccctcc   3720

tttagaactc attttctctt cccaaaaagt gttatctttt ccttaaatat ccctctagag   3780

gtatttttcc taagtggtat tgtacggtgt atactgttct tcagcttgtc ttctctgtgt   3840

aacatatttt tgagattgtc ccatgtcgtt acatgaagag tttcttgatt cttggtctat   3900

aattgcagat gttattgtat gaatgtacca taatatattt gagcagtccc tgctgacatt   3960

tttttcctaa ccttttgcta ttataaataa tgattcattt tataaccttt tatataggtc   4020

acattgcaca tgagtgagtt tactgtaagc tggaaatcta aagttagaat tactaggtta   4080

agatatgtgc atttttactt ttgatagata ttggcaagtt gccatctata aggattgtgc   4140

cagtttacag tcccacccac aatgcatgag agtgcctatt aaatctttgt aagtgttatc   4200


<210>  5795
<211>  1142
<212>  PRT
<213>  Homosapiens

<400>  5795

Met Lys Glu Pro Leu Leu Gly Gly Glu Cys Asp Lys Ala Val Ala Ser 
1               5                   10                  15      


Gln Leu Gly Leu Leu Asp Glu Ile Lys Thr Glu Pro Asp Asn Ala Gln 
            20                  25                  30          


Glu Tyr Cys His Arg Gln Gln Ser Arg Thr Gln Glu Asn Glu Leu Lys 
        35                  40                  45              


Ile Asn Ala Val Phe Ser Glu Ser Ala Ser Gln Leu Thr Ala Gly Ile 
    50                  55                  60                  


Gln Leu Ser Leu Ala Ser Ser Gly Val Asn Lys Met Leu Pro Ser Val 
65                  70                  75                  80  


Ser Thr Thr Ala Ile Gln Val Ser Cys Ala Gly Cys Lys Lys Ile Leu 
                85                  90                  95      


Gln Lys Gly Gln Thr Ala Tyr Gln Arg Lys Gly Ser Ala Gln Leu Phe 
            100                 105                 110         


Cys Ser Ile Pro Cys Ile Thr Glu Tyr Ile Ser Ser Ala Ser Ser Pro 
        115                 120                 125             


Val Pro Ser Lys Arg Thr Cys Ser Asn Cys Ser Lys Asp Ile Leu Asn 
    130                 135                 140                 


Pro Lys Asp Val Ile Ser Val Gln Leu Glu Asp Thr Thr Ser Cys Lys 
145                 150                 155                 160 


Thr Phe Cys Ser Leu Ser Cys Leu Ser Ser Tyr Glu Glu Lys Arg Lys 
                165                 170                 175     


Pro Phe Val Thr Ile Cys Thr Asn Ser Ile Leu Thr Lys Cys Ser Met 
            180                 185                 190         


Cys Gln Lys Thr Ala Ile Ile Gln Tyr Glu Val Lys Tyr Gln Asn Val 
        195                 200                 205             


Lys His Asn Leu Cys Ser Asn Ala Cys Leu Ser Lys Phe His Ser Ala 
    210                 215                 220                 


Asn Asn Phe Ile Met Asn Cys Cys Glu Asn Cys Gly Thr Tyr Cys Tyr 
225                 230                 235                 240 


Thr Ser Ser Ser Leu Ser His Ile Leu Gln Met Glu Gly Gln Ser His 
                245                 250                 255     


Tyr Phe Asn Ser Ser Lys Ser Ile Thr Ala Tyr Lys Gln Lys Pro Ala 
            260                 265                 270         


Lys Pro Leu Ile Ser Val Pro Cys Lys Pro Leu Lys Pro Ser Asp Glu 
        275                 280                 285             


Met Ile Glu Thr Thr Ser Asp Leu Gly Lys Thr Glu Leu Phe Cys Ser 
    290                 295                 300                 


Ile Asn Cys Phe Ser Ala Tyr Ser Lys Ala Lys Met Glu Ser Ser Ser 
305                 310                 315                 320 


Val Ser Val Val Ser Val Val His Asp Thr Ser Thr Glu Leu Leu Ser 
                325                 330                 335     


Pro Lys Lys Asp Thr Thr Pro Val Ile Ser Asn Ile Val Ser Leu Ala 
            340                 345                 350         


Asp Thr Asp Val Ala Leu Pro Ile Met Asn Thr Asp Val Leu Gln Asp 
        355                 360                 365             


Thr Val Ser Ser Val Thr Ala Thr Ala Asp Val Ile Val Asp Leu Ser 
    370                 375                 380                 


Lys Ser Ser Pro Ser Glu Pro Ser Asn Ala Val Ala Ser Ser Ser Thr 
385                 390                 395                 400 


Glu Gln Pro Ser Val Ser Pro Ser Ser Ser Val Phe Ser Gln His Ala 
                405                 410                 415     


Ile Gly Ser Ser Thr Glu Val Gln Lys Asp Asn Met Lys Ser Met Lys 
            420                 425                 430         


Ile Ser Asp Glu Leu Cys His Pro Lys Cys Thr Ser Lys Val Gln Lys 
        435                 440                 445             


Val Lys Gly Lys Ser Arg Ser Ile Lys Lys Ser Cys Cys Ala Asp Phe 
    450                 455                 460                 


Glu Cys Leu Glu Asn Ser Lys Lys Asp Val Ala Phe Cys Tyr Ser Cys 
465                 470                 475                 480 


Gln Leu Phe Cys Gln Lys Tyr Phe Ser Cys Gly Arg Glu Ser Phe Ala 
                485                 490                 495     


Thr His Gly Thr Ser Asn Trp Lys Lys Thr Leu Glu Lys Phe Arg Lys 
            500                 505                 510         


His Glu Lys Ser Glu Met His Leu Lys Ser Leu Glu Phe Trp Arg Glu 
        515                 520                 525             


Tyr Gln Phe Cys Asp Gly Ala Val Ser Asp Asp Leu Ser Ile His Ser 
    530                 535                 540                 


Lys Gln Ile Glu Gly Asn Lys Lys Tyr Leu Lys Leu Ile Ile Glu Asn 
545                 550                 555                 560 


Ile Leu Phe Leu Gly Lys Gln Cys Leu Pro Leu Arg Gly Asn Asp Gln 
                565                 570                 575     


Ser Val Ser Ser Val Asn Lys Gly Asn Phe Leu Glu Leu Leu Glu Met 
            580                 585                 590         


Arg Ala Lys Asp Lys Gly Glu Glu Thr Phe Arg Leu Met Asn Ser Gln 
        595                 600                 605             


Val Asp Phe Tyr Asn Ser Thr Gln Ile Gln Ser Asp Ile Ile Glu Ile 
    610                 615                 620                 


Ile Lys Thr Glu Met Leu Gln Asp Ile Val Asn Glu Ile Asn Asp Ser 
625                 630                 635                 640 


Ser Ala Phe Ser Ile Ile Cys Asp Glu Thr Ile Asn Ser Ala Met Lys 
                645                 650                 655     


Glu Gln Leu Ser Ile Cys Val Arg Tyr Pro Gln Lys Ser Ser Lys Ala 
            660                 665                 670         


Ile Leu Ile Lys Glu Arg Phe Leu Gly Phe Val Asp Thr Glu Glu Met 
        675                 680                 685             


Thr Gly Thr His Leu His Arg Thr Ile Lys Thr Tyr Leu Gln Gln Ile 
    690                 695                 700                 


Gly Val Asp Met Asp Lys Ile His Gly Gln Ala Tyr Asp Ser Thr Thr 
705                 710                 715                 720 


Asn Leu Lys Ile Lys Phe Asn Lys Ile Ala Ala Glu Phe Lys Lys Glu 
                725                 730                 735     


Glu Pro Arg Ala Leu Tyr Ile His Cys Tyr Ala His Phe Leu Asp Leu 
            740                 745                 750         


Ser Ile Ile Arg Phe Cys Lys Glu Val Lys Glu Leu Arg Ser Ala Leu 
        755                 760                 765             


Lys Thr Leu Ser Ser Leu Phe Asn Thr Ile Cys Met Ser Gly Glu Met 
    770                 775                 780                 


Leu Ala Asn Phe Arg Asn Ile Tyr Arg Leu Ser Gln Asn Lys Thr Cys 
785                 790                 795                 800 


Lys Lys His Ile Ser Gln Ser Cys Trp Thr Val His Asp Arg Thr Leu 
                805                 810                 815     


Leu Ser Val Ile Asp Ser Leu Pro Glu Ile Ile Glu Thr Leu Glu Val 
            820                 825                 830         


Ile Ala Ser His Ser Ser Asn Thr Ser Phe Ala Asp Glu Leu Ser His 
        835                 840                 845             


Leu Leu Thr Leu Val Ser Lys Phe Glu Phe Val Phe Cys Leu Lys Phe 
    850                 855                 860                 


Leu Tyr Arg Val Leu Ser Val Thr Gly Ile Leu Ser Lys Glu Leu Gln 
865                 870                 875                 880 


Asn Lys Thr Ile Asp Ile Phe Ser Leu Ser Ser Lys Ile Glu Ala Ile 
                885                 890                 895     


Leu Glu Cys Leu Ser Ser Glu Arg Asn Asp Val Tyr Phe Lys Thr Ile 
            900                 905                 910         


Trp Asp Gly Thr Glu Glu Ile Cys Gln Lys Ile Thr Cys Lys Gly Phe 
        915                 920                 925             


Lys Val Glu Lys Pro Ser Leu Gln Lys Arg Arg Lys Ile Gln Lys Ser 
    930                 935                 940                 


Val Asp Leu Gly Asn Ser Asp Asn Met Phe Phe Pro Thr Ser Thr Glu 
945                 950                 955                 960 


Glu Gln Tyr Lys Ile Asn Ile Tyr Tyr Gln Gly Leu Asp Thr Ile Leu 
                965                 970                 975     


Gln Asn Leu Lys Leu Cys Phe Ser Glu Phe Asp Tyr Cys Lys Ile Lys 
            980                 985                 990         


Gln Ile Ser Glu Leu Leu Phe Lys  Trp Asn Glu Pro Leu  Asn Glu Thr 
        995                 1000                 1005             


Thr Ala  Lys His Val Gln Glu  Phe Tyr Lys Leu Asp  Glu Asp Ile 
    1010                 1015                 1020             


Ile Pro  Glu Leu Arg Phe Tyr  Arg His Tyr Ala Lys  Leu Asn Phe 
    1025                 1030                 1035             


Val Ile  Asp Asp Ser Cys Ile  Asn Phe Val Ser Leu  Gly Cys Leu 
    1040                 1045                 1050             


Phe Ile  Gln His Gly Leu His  Ser Asn Ile Pro Cys  Leu Ser Lys 
    1055                 1060                 1065             


Leu Leu  Tyr Ile Ala Leu Ser  Trp Pro Ile Thr Ser  Ala Ser Thr 
    1070                 1075                 1080             


Glu Asn  Ser Phe Ser Thr Leu  Pro Arg Leu Lys Thr  Tyr Leu Cys 
    1085                 1090                 1095             


Asn Thr  Met Gly Gln Glu Lys  Leu Thr Gly Pro Ala  Leu Met Ala 
    1100                 1105                 1110             


Val Glu  Gln Glu Leu Val Asn  Lys Leu Met Glu Pro  Glu Arg Leu 
    1115                 1120                 1125             


Asn Glu  Ile Val Glu Lys Phe  Ile Ser Gln Met Lys  Glu Ile 
    1130                 1135                 1140         


<210>  5796
<211>  3982
<212>  DNA
<213>  Homosapiens

<400>  5796
gcttcgaaga ttgtttcaga agcgttgggc ggggcgtccc tgagagaaat tagagtattg     60

tcataggcaa cagtccagaa ctcaggagaa tgaactgaaa ataaatgctg tgttttcaga    120

gagtgcttca cagttgactg caggcattca gctttctctg gcatcatctg gcgtgaataa    180

aatgcttcct tcagtttcaa ccacagctat tcaggtttcc tgtgctggtt gtaaaaaaat    240

tctccagaag gggcaaactg cttatcagag gaaaggatct gctcaacttt tctgctccat    300

accatgcatc actgaataca tttcatctgc cagttcacca gttccttcta agagaacttg    360

ttcaaactgc tcaaaagaca ttttaaatcc aaaggatgtg attagtgtcc agctggaaga    420

cactacctct tgcaaaactt tttgcagcct atcttgtctt tcatcatatg aagaaaaaag    480

aaaaccattt gttaccatat gtactaatag cattttgacc aagtgcagca tgtgccagaa    540

gactgctatt attcagtatg aagtaaaata ccaaaatgtg aaacataatc tttgcagtaa    600

tgcctgcctt tcaaagtttc actctgctaa caacttcatc atgaactgct gtgagaactg    660

tggcacttac tgttacacca gctctagtct gtcccacata cttcagatgg aaggacagtc    720

tcattacttt aatagttcaa agagtattac agcatataag cagaaacctg ccaaaccact    780

tatatctgtt ccttgcaaac cattgaagcc ctcagatgaa atgattgaga ctacgagtga    840

tttggggaag acagagcttt tctgctctat taattgtttc tctgcataca gtaaagctaa    900

gatggaatct tcttcagtaa gtgttgtttc tgtggtgcat gatacttcaa cagagcttct    960

ttctccaaag aaagatacga ctccagttat aagcaatata gtgtcattgg cagacaccga   1020

tgttgccttg cccatcatga acactgatgt cttacaagat acagtttctt cagtaacagc   1080

aacagcagat gtcattgtgg atctttctaa gagttcacct agtgaaccca gtaatgctgt   1140

tgctagtagt agtacggaac agccaagcgt ttcaccatct tcatcagtat tcagtcagca   1200

tgcaattggt tccagtacag aagtacaaaa agacaatatg aaatctatga aaataagtga   1260

tgaactatgt cacccaaaat gtacatccaa agtacaaaaa gttaaaggta aatcacgaag   1320

tattaaaaaa tcttgttgtg cagattttga gtgtttggaa aacagtaaaa aagatgtggc   1380

attctgttat tcatgccagt tgttctgcca aaaatatttt agctgtggaa gagagtcatt   1440

tgcaacccac ggaacttcta attggaaaaa aaccctggaa aaattcagaa agcatgaaaa   1500

aagtgaaatg catttgaagt cattggaatt ttggagagaa taccaatttt gtgatggagc   1560

tgtcagtgac gatttatcta ttcattcgaa acagattgag ggaaataaaa agtacctaaa   1620

gcttataatt gaaaatattt tatttcttgg aaagcagtgt ttacccttaa gaggaaacga   1680

ccagtcagtt tcatctgtga ataaaggcaa ttttttagaa ttgttagaaa tgagagcaaa   1740

agataaagga gaagaaacat ttcgacttat gaattcacaa gttgacttct ataacagtac   1800

acaaattcaa agtgatatta tcgaaataat aaagactgaa atgttgcagg atattgtgaa   1860

tgagatcaat gactcctcag cattttcaat catatgtgat gagacaatca atagtgccat   1920

gaaagaacag ctttcaattt gtgtaagata cccacaaaaa tcatcaaagg ctatcttaat   1980

taaggaaaga ttcttgggtt ttgttgatac tgaggagatg actgggaccc acttacatag   2040

gactatcaaa acttatctgc agcaaattgg agttgatatg gataaaatac atggccaggc   2100

ctatgatagc accactaatt tgaagataaa atttaataaa atagcagcag aattcaagaa   2160

agaagaacca agagctttat acatacattg ttatgcacac tttttggatt tatcaataat   2220

taggttttgt aaagaagtaa aagaactccg aagtgctcta aaaactctca gttctttgtt   2280

caacactatt tgtatgtctg gggaaatgtt ggcaaatttt cgaaacattt ataggctaag   2340

tcaaaacaaa acatgcaaga aacatatatc acaatcatgt tggacagtcc atgatcgtac   2400

attactatct gtgattgaca gtcttccaga gattattgaa acattggaag ttatagcaag   2460

ccattcttca aatacaagtt tcgccgatga attgagtcat ttgctgacat tggtttccaa   2520

atttgaattt gtcttttgtt tgaaattcct gtatcgagtg ctgagtgtta caggaattct   2580

ttccaaagag cttcaaaata aaaccataga cattttttct ttgtcttcaa aaatagaagc   2640

aattttggaa tgtttatcat ctgaaagaaa tgacgtatac tttaaaacaa tctgggatgg   2700

aacagaggaa atatgtcaaa aaataacctg taaaggtttt aaagttgaaa aaccttctct   2760

tcagaaaaga agaaaaattc agaaatcagt agatcttggc aattcagata atatgttttt   2820

tcctacttca acagaagaac aatataaaat taatatctat taccaaggat tagatactat   2880

attacaaaat ttaaagttat gtttttcgga gtttgattat tgcaaaataa agcaaatttc   2940

agaactgtta tttaaatgga atgaaccatt aaatgaaaca acagcaaaac atgttcagga   3000

attttataaa cttgatgagg acattatccc agaacttaga ttttatcgac attatgcaaa   3060

gcttaacttt gtcatagatg atagttgcat aaacttcgtc agtctcggct gtttgtttat   3120

tcagcatggt cttcacagta atattccttg tctctcaaag ctattatata ttgctttgtc   3180

ttggccaatt acttcagcaa gtactgagaa ctcattttct accctgcctc gtcttaagac   3240

atatttatgt aataccatgg gacaagagaa gcttactggc ccagccctaa tggctgttga   3300

gcaggagttg gtaaataaac taatggagcc tgaaagactc aatgaaattg tggaaaagtt   3360

tatcagtcag atgaaagaaa tataatacat gctcatttga acttacctaa aagacttgta   3420

tttccattgg gatgttttca tttcaaaatt gttcaaaatt caaaagacac agaacgataa   3480

acagtgaagt ctccttccct cctttagaac tcattttctc ttcccaaaaa gtgttatctt   3540

ttccttaaat atccctctag aggtattttt cctaagtggt attgtacggt gtatactgtt   3600

cttcagcttg tcttctctgt gtaacatatt tttgagattg tcccatgtcg ttacatgaag   3660

agtttcttga ttcttggtct ataattgcag atgttattgt atgaatgtac cataatatat   3720

ttgagcagtc cctgctgaca tttttttcct aaccttttgc tattataaat aatgattcat   3780

tttataacct tttatatagg tcacattgca catgagtgag tttactgtaa gctggaaatc   3840

taaagttaga attactaggt taagatatgt gcatttttac ttttgataga tattggcaag   3900

ttgccatcta taaggattgt gccagtttac agtcccaccc acaatgcatg agagtgccta   3960

ttaaatcttt gtaagtgtta tc                                            3982


<210>  5797
<211>  1067
<212>  PRT
<213>  Homosapiens

<400>  5797

Met Leu Pro Ser Val Ser Thr Thr Ala Ile Gln Val Ser Cys Ala Gly 
1               5                   10                  15      


Cys Lys Lys Ile Leu Gln Lys Gly Gln Thr Ala Tyr Gln Arg Lys Gly 
            20                  25                  30          


Ser Ala Gln Leu Phe Cys Ser Ile Pro Cys Ile Thr Glu Tyr Ile Ser 
        35                  40                  45              


Ser Ala Ser Ser Pro Val Pro Ser Lys Arg Thr Cys Ser Asn Cys Ser 
    50                  55                  60                  


Lys Asp Ile Leu Asn Pro Lys Asp Val Ile Ser Val Gln Leu Glu Asp 
65                  70                  75                  80  


Thr Thr Ser Cys Lys Thr Phe Cys Ser Leu Ser Cys Leu Ser Ser Tyr 
                85                  90                  95      


Glu Glu Lys Arg Lys Pro Phe Val Thr Ile Cys Thr Asn Ser Ile Leu 
            100                 105                 110         


Thr Lys Cys Ser Met Cys Gln Lys Thr Ala Ile Ile Gln Tyr Glu Val 
        115                 120                 125             


Lys Tyr Gln Asn Val Lys His Asn Leu Cys Ser Asn Ala Cys Leu Ser 
    130                 135                 140                 


Lys Phe His Ser Ala Asn Asn Phe Ile Met Asn Cys Cys Glu Asn Cys 
145                 150                 155                 160 


Gly Thr Tyr Cys Tyr Thr Ser Ser Ser Leu Ser His Ile Leu Gln Met 
                165                 170                 175     


Glu Gly Gln Ser His Tyr Phe Asn Ser Ser Lys Ser Ile Thr Ala Tyr 
            180                 185                 190         


Lys Gln Lys Pro Ala Lys Pro Leu Ile Ser Val Pro Cys Lys Pro Leu 
        195                 200                 205             


Lys Pro Ser Asp Glu Met Ile Glu Thr Thr Ser Asp Leu Gly Lys Thr 
    210                 215                 220                 


Glu Leu Phe Cys Ser Ile Asn Cys Phe Ser Ala Tyr Ser Lys Ala Lys 
225                 230                 235                 240 


Met Glu Ser Ser Ser Val Ser Val Val Ser Val Val His Asp Thr Ser 
                245                 250                 255     


Thr Glu Leu Leu Ser Pro Lys Lys Asp Thr Thr Pro Val Ile Ser Asn 
            260                 265                 270         


Ile Val Ser Leu Ala Asp Thr Asp Val Ala Leu Pro Ile Met Asn Thr 
        275                 280                 285             


Asp Val Leu Gln Asp Thr Val Ser Ser Val Thr Ala Thr Ala Asp Val 
    290                 295                 300                 


Ile Val Asp Leu Ser Lys Ser Ser Pro Ser Glu Pro Ser Asn Ala Val 
305                 310                 315                 320 


Ala Ser Ser Ser Thr Glu Gln Pro Ser Val Ser Pro Ser Ser Ser Val 
                325                 330                 335     


Phe Ser Gln His Ala Ile Gly Ser Ser Thr Glu Val Gln Lys Asp Asn 
            340                 345                 350         


Met Lys Ser Met Lys Ile Ser Asp Glu Leu Cys His Pro Lys Cys Thr 
        355                 360                 365             


Ser Lys Val Gln Lys Val Lys Gly Lys Ser Arg Ser Ile Lys Lys Ser 
    370                 375                 380                 


Cys Cys Ala Asp Phe Glu Cys Leu Glu Asn Ser Lys Lys Asp Val Ala 
385                 390                 395                 400 


Phe Cys Tyr Ser Cys Gln Leu Phe Cys Gln Lys Tyr Phe Ser Cys Gly 
                405                 410                 415     


Arg Glu Ser Phe Ala Thr His Gly Thr Ser Asn Trp Lys Lys Thr Leu 
            420                 425                 430         


Glu Lys Phe Arg Lys His Glu Lys Ser Glu Met His Leu Lys Ser Leu 
        435                 440                 445             


Glu Phe Trp Arg Glu Tyr Gln Phe Cys Asp Gly Ala Val Ser Asp Asp 
    450                 455                 460                 


Leu Ser Ile His Ser Lys Gln Ile Glu Gly Asn Lys Lys Tyr Leu Lys 
465                 470                 475                 480 


Leu Ile Ile Glu Asn Ile Leu Phe Leu Gly Lys Gln Cys Leu Pro Leu 
                485                 490                 495     


Arg Gly Asn Asp Gln Ser Val Ser Ser Val Asn Lys Gly Asn Phe Leu 
            500                 505                 510         


Glu Leu Leu Glu Met Arg Ala Lys Asp Lys Gly Glu Glu Thr Phe Arg 
        515                 520                 525             


Leu Met Asn Ser Gln Val Asp Phe Tyr Asn Ser Thr Gln Ile Gln Ser 
    530                 535                 540                 


Asp Ile Ile Glu Ile Ile Lys Thr Glu Met Leu Gln Asp Ile Val Asn 
545                 550                 555                 560 


Glu Ile Asn Asp Ser Ser Ala Phe Ser Ile Ile Cys Asp Glu Thr Ile 
                565                 570                 575     


Asn Ser Ala Met Lys Glu Gln Leu Ser Ile Cys Val Arg Tyr Pro Gln 
            580                 585                 590         


Lys Ser Ser Lys Ala Ile Leu Ile Lys Glu Arg Phe Leu Gly Phe Val 
        595                 600                 605             


Asp Thr Glu Glu Met Thr Gly Thr His Leu His Arg Thr Ile Lys Thr 
    610                 615                 620                 


Tyr Leu Gln Gln Ile Gly Val Asp Met Asp Lys Ile His Gly Gln Ala 
625                 630                 635                 640 


Tyr Asp Ser Thr Thr Asn Leu Lys Ile Lys Phe Asn Lys Ile Ala Ala 
                645                 650                 655     


Glu Phe Lys Lys Glu Glu Pro Arg Ala Leu Tyr Ile His Cys Tyr Ala 
            660                 665                 670         


His Phe Leu Asp Leu Ser Ile Ile Arg Phe Cys Lys Glu Val Lys Glu 
        675                 680                 685             


Leu Arg Ser Ala Leu Lys Thr Leu Ser Ser Leu Phe Asn Thr Ile Cys 
    690                 695                 700                 


Met Ser Gly Glu Met Leu Ala Asn Phe Arg Asn Ile Tyr Arg Leu Ser 
705                 710                 715                 720 


Gln Asn Lys Thr Cys Lys Lys His Ile Ser Gln Ser Cys Trp Thr Val 
                725                 730                 735     


His Asp Arg Thr Leu Leu Ser Val Ile Asp Ser Leu Pro Glu Ile Ile 
            740                 745                 750         


Glu Thr Leu Glu Val Ile Ala Ser His Ser Ser Asn Thr Ser Phe Ala 
        755                 760                 765             


Asp Glu Leu Ser His Leu Leu Thr Leu Val Ser Lys Phe Glu Phe Val 
    770                 775                 780                 


Phe Cys Leu Lys Phe Leu Tyr Arg Val Leu Ser Val Thr Gly Ile Leu 
785                 790                 795                 800 


Ser Lys Glu Leu Gln Asn Lys Thr Ile Asp Ile Phe Ser Leu Ser Ser 
                805                 810                 815     


Lys Ile Glu Ala Ile Leu Glu Cys Leu Ser Ser Glu Arg Asn Asp Val 
            820                 825                 830         


Tyr Phe Lys Thr Ile Trp Asp Gly Thr Glu Glu Ile Cys Gln Lys Ile 
        835                 840                 845             


Thr Cys Lys Gly Phe Lys Val Glu Lys Pro Ser Leu Gln Lys Arg Arg 
    850                 855                 860                 


Lys Ile Gln Lys Ser Val Asp Leu Gly Asn Ser Asp Asn Met Phe Phe 
865                 870                 875                 880 


Pro Thr Ser Thr Glu Glu Gln Tyr Lys Ile Asn Ile Tyr Tyr Gln Gly 
                885                 890                 895     


Leu Asp Thr Ile Leu Gln Asn Leu Lys Leu Cys Phe Ser Glu Phe Asp 
            900                 905                 910         


Tyr Cys Lys Ile Lys Gln Ile Ser Glu Leu Leu Phe Lys Trp Asn Glu 
        915                 920                 925             


Pro Leu Asn Glu Thr Thr Ala Lys His Val Gln Glu Phe Tyr Lys Leu 
    930                 935                 940                 


Asp Glu Asp Ile Ile Pro Glu Leu Arg Phe Tyr Arg His Tyr Ala Lys 
945                 950                 955                 960 


Leu Asn Phe Val Ile Asp Asp Ser Cys Ile Asn Phe Val Ser Leu Gly 
                965                 970                 975     


Cys Leu Phe Ile Gln His Gly Leu His Ser Asn Ile Pro Cys Leu Ser 
            980                 985                 990         


Lys Leu Leu Tyr Ile Ala Leu Ser  Trp Pro Ile Thr Ser  Ala Ser Thr 
        995                 1000                 1005             


Glu Asn  Ser Phe Ser Thr Leu  Pro Arg Leu Lys Thr  Tyr Leu Cys 
    1010                 1015                 1020             


Asn Thr  Met Gly Gln Glu Lys  Leu Thr Gly Pro Ala  Leu Met Ala 
    1025                 1030                 1035             


Val Glu  Gln Glu Leu Val Asn  Lys Leu Met Glu Pro  Glu Arg Leu 
    1040                 1045                 1050             


Asn Glu  Ile Val Glu Lys Phe  Ile Ser Gln Met Lys  Glu Ile 
    1055                 1060                 1065         


<210>  5798
<211>  608
<212>  DNA
<213>  Homosapiens

<400>  5798
gaggggtagt gagtacagat tgggttaacc tcagatagaa agctttacat ttcttttttg     60

tttgtttgtt tgtttgttga gacacagtct cactctgtca cccaggctgg agtgcagtgg    120

ctcaatgtcc attcactgcg acctccacct cccaggttca agcgattctc gtgcctcagc    180

ctcccgagta gctgggatta caggaatctg gaaactgttc ttcaggaaga aacccattag    240

tttggaactg gagaattcct ttgcatcaga tactaaaatg aaagaaccac ttttaggtgg    300

tgagtgtgac aaggcagtgg catcacagct ggggctgcta gatgaaatta agacagaacc    360

cgacaatgct caagagtatt gtcataggca acagtccaga actcaggaga atgaactgaa    420

aataaatgct gtgttttcag agagtgcttc acagttgact gcaggcattc agctttctct    480

ggcatcatct ggcgtgaata aaatgcttcc ttcagtttca accacagcta ttcaggtttc    540

ctgtgctggt tgtaaaaaaa ttctccagaa ggggcaaact gcttatcaga ggaaaggatc    600

tgctcaac                                                             608


<210>  5799
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  5799

Met Ser Ile His Cys Asp Leu His Leu Pro Gly Ser Ser Asp Ser Arg 
1               5                   10                  15      


Ala Ser Ala Ser Arg Val Ala Gly Ile Thr Gly Ile Trp Lys Leu Phe 
            20                  25                  30          


Phe Arg Lys Lys Pro Ile Ser Leu Glu Leu Glu Asn Ser Phe Ala Ser 
        35                  40                  45              


Asp Thr Lys Met Lys Glu Pro Leu Leu Gly Gly Glu Cys Asp Lys Ala 
    50                  55                  60                  


Val Ala Ser Gln Leu Gly Leu Leu Asp Glu Ile Lys Thr Glu Pro Asp 
65                  70                  75                  80  


Asn Ala Gln Glu Tyr Cys His Arg Gln Gln Ser Arg Thr Gln Glu Asn 
                85                  90                  95      


Glu Leu Lys Ile Asn Ala Val Phe Ser Glu Ser Ala Ser Gln Leu Thr 
            100                 105                 110         


Ala Gly Ile Gln Leu Ser Leu Ala Ser Ser Gly Val Asn Lys Met Leu 
        115                 120                 125             


Pro Ser Val Ser Thr Thr Ala Ile Gln Val Ser Cys Ala Gly Cys Lys 
    130                 135                 140                 


Lys Ile Leu Gln Lys Gly Gln Thr Ala Tyr Gln Arg Lys Gly Ser Ala 
145                 150                 155                 160 


<210>  5800
<211>  594
<212>  DNA
<213>  Homosapiens

<400>  5800
agttataatt gtgtttaaac tgtttaatga tgtccttgtt atttattctt agagacattt     60

taaatccaaa ggatgtgatt agtgtccagc tggaagacac tacctcttgc aaaacttttt    120

gcagcctatc ttgtctttca tcatatgaag aaaaaagaaa accatttgtt accatatgta    180

ctaatagcat tttgaccaag tgcagcatgt gccagaagac tgctattatt cagtatgaag    240

taaaatacca aaatgtgaaa cataatcttt gcagtaatgc ctgcctttca aagtttcact    300

ctgctaacaa cttcatcatg aactgctgtg agaactgtgg cacttactgt tacaccagct    360

ctagtctgtc ccacatactt cagatggaag gacagtctca ttactttaat agttcaaaga    420

gtattacagc atataagcag aaacctgcca aaccacttat atctgttcct tgcaaaccat    480

tgaagccctc agatgaaatg attgagacta cgagtgattt ggggaagaca gagcttttct    540

gctctattaa ttgtttctct gcatacagta aagctaagat ggaatcttct tcag          594


<210>  5801
<211>  188
<212>  PRT
<213>  Homosapiens

<400>  5801

Met Met Ser Leu Leu Phe Ile Leu Arg Asp Ile Leu Asn Pro Lys Asp 
1               5                   10                  15      


Val Ile Ser Val Gln Leu Glu Asp Thr Thr Ser Cys Lys Thr Phe Cys 
            20                  25                  30          


Ser Leu Ser Cys Leu Ser Ser Tyr Glu Glu Lys Arg Lys Pro Phe Val 
        35                  40                  45              


Thr Ile Cys Thr Asn Ser Ile Leu Thr Lys Cys Ser Met Cys Gln Lys 
    50                  55                  60                  


Thr Ala Ile Ile Gln Tyr Glu Val Lys Tyr Gln Asn Val Lys His Asn 
65                  70                  75                  80  


Leu Cys Ser Asn Ala Cys Leu Ser Lys Phe His Ser Ala Asn Asn Phe 
                85                  90                  95      


Ile Met Asn Cys Cys Glu Asn Cys Gly Thr Tyr Cys Tyr Thr Ser Ser 
            100                 105                 110         


Ser Leu Ser His Ile Leu Gln Met Glu Gly Gln Ser His Tyr Phe Asn 
        115                 120                 125             


Ser Ser Lys Ser Ile Thr Ala Tyr Lys Gln Lys Pro Ala Lys Pro Leu 
    130                 135                 140                 


Ile Ser Val Pro Cys Lys Pro Leu Lys Pro Ser Asp Glu Met Ile Glu 
145                 150                 155                 160 


Thr Thr Ser Asp Leu Gly Lys Thr Glu Leu Phe Cys Ser Ile Asn Cys 
                165                 170                 175     


Phe Ser Ala Tyr Ser Lys Ala Lys Met Glu Ser Ser 
            180                 185             


<210>  5802
<211>  720
<212>  DNA
<213>  Homosapiens

<400>  5802
gagtagctgg aattacaggc acccaccacc acacctggct catttttttt gtatttttag     60

tagagatggg gtttcaccat gttggccagg ctggtcttga attcttgacc ttgtgatccg    120

cctgccttag cctcccaaag tgttgggatt ataggcgtga gctaccgtcc ccagcctatt    180

ttctctcttt tttgaaacgg agtttctctc ttgttgccca gactagagtg caattgcacg    240

atctcagctc actgcaacca cagcctttgg ggttcaagct attctcccgt ctcagcctcc    300

cgagtagctg gtattacagg catgtgccac cacgcccggc taattttata gttttagtag    360

agacggggtt tctccatgtt agtcaggcgt ggtggtgggc acctgtaatc ccatatactt    420

gggaagctga ggcaggagaa tcacttgaac ccgcgaggtg gaggttgcag tgagccaata    480

tcacgccacc gtacactcca gcctgggcaa cagagcgaga ctccgtctta aaaaatgaaa    540

gaaagaaagt aaaacaggta tatagaagat actgagaata ttttctacaa ctctaggcaa    600

atgcatttga aagaaagcct caatgaaata gatgttctcc tagaaaaagt acaagttatc    660

aaaattgatg agagggtaag ggagaaacag ctggagaaaa gtgccagaga aatagtcttt    720


<210>  5803
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  5803

Met His Leu Lys Glu Ser Leu Asn Glu Ile Asp Val Leu Leu Glu Lys 
1               5                   10                  15      


Val Gln Val Ile Lys Ile Asp Glu Arg Val Arg Glu Lys Gln Leu Glu 
            20                  25                  30          


Lys Ser Ala Arg Glu Ile Val 
        35                  


<210>  5804
<211>  504
<212>  DNA
<213>  Homosapiens

<400>  5804
acttttctcc agctgtttct cccttaccct ctcatcaatt ttgataactt gtactttttc     60

taggagaaca tctatttcat tgaggctttc tttcaaatgc atttgcctag agttgtagaa    120

aatattctca gtatcttcta tatacctgtt ttactttctt tctttcattt ttctgggcaa    180

caagagagaa actccgtttc aaaaaagaga gaaaataggc tggggacggt agctcacgcc    240

tataatccca acactttggg aggctaaggc aggcggatca caaggtcaag aattcaagac    300

cagcctggcc aacatggtga aaccccatct ctactaaaaa tacaaaaaaa atgagccagg    360

tgtggtggtg ggtgcctgta attccagcta ctcaggaggc taaggcagga gaatcacttg    420

aacccaggag gcagaggttg cagtgagcca agatcgtgcc attgcactcc agcctgggcg    480

acaagagtga aactccgtct caaa                                           504


<210>  5805
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  5805

Met His Leu Pro Arg Val Val Glu Asn Ile Leu Ser Ile Phe Tyr Ile 
1               5                   10                  15      


Pro Val Leu Leu Ser Phe Phe His Phe Ser Gly Gln Gln Glu Arg Asn 
            20                  25                  30          


Ser Val Ser Lys Lys Arg Glu Asn Arg Leu Gly Thr Val Ala His Ala 
        35                  40                  45              


Tyr Asn Pro Asn Thr Leu Gly Gly 
    50                  55      


<210>  5806
<211>  2948
<212>  DNA
<213>  Homosapiens

<400>  5806
aattagtctc tattgtagca aactgacctg cccatagatc ggcaatatca gtaatttcat     60

tatgcaatct tggtaattct acaagttgag ttgaactaaa agtacaggtt tttttgtaat    120

gcgatttaaa atttttaaaa acatgggctt catgaaaaca ccattgttac taacttgggc    180

ttagatggga atctaatgtg aatagttcaa gttatgggac ttgtctaaat gtgtctatac    240

tctaaacctg ggggaaggtg gtgtggaaca ttgacttgac tacagtcgaa tacatgttgg    300

gaatcattcc caatcataag acatcgtcgt ttctgtagga tgactgcata tgttcagagt    360

agctttttga atttggttcc cttagcttta gggatgtgat gttatagtcc aaaatgttta    420

caagaaaacc taagtcttca aaagcacaac ttttgttgct taggactttg catcaactgt    480

tgttccagac ctcacttcaa cttcttggtc tctgaactgg ttttagctag catgcatgag    540

agacagtttt catgtataat gtttctgctc tgtaactgga aagtggttta ctttgcataa    600

atgctgatga aaacttcatg actatgagac ttttcttctg tgtatcaaga aaaagcttgc    660

tcgttggcaa gcaattcaca aggtggggac agacttgtac tttaacatgt agtccattca    720

agcaaacaac tttggactct actgatagat gaaagagcaa atgatgacta gtttagcctc    780

tgcatatcaa caatataatg cagatcaagt ataatgctca atattagtga catgagtatc    840

actaaattac atagaaccct gatggggttt cctgtgtcgt aatccattaa atcggtggcc    900

agtgcttgct gccgtggttt agtgattggg tgttagaaat aaaaactcag gtctatttct    960

taccagtcag taacaatttt tagagaatgt acttggtata taatatatgg acttcaggaa   1020

ctttattggg gtggggggtt aattttgcct taccctgttc actttcagat gattaggctt   1080

ttgcacttta gaatgagaaa cttgtgacgt tagtgtgttc ttactagctt taatttgtat   1140

gtagcaatga attgtgaatc ttagtgcagt gggttttttt aaaaaactca aaaagctggg   1200

aattaagtgg tttcagtaat aatgctatac cgaggtgctt gcattgtatt tcataatttt   1260

gttacaaacc aaaattattt ttaatgagaa cagtcttggg ttcagaggtg tgatgccaga   1320

atgtattttc gtactgttag gcccttggaa cagataccgg tgctttctga aagatgaaag   1380

aaatgcaatg ggtgctcttc atgcaaggtt gcaaacctac caagaatgca taatagtctc   1440

acttttcccc aataaagaga tgcgtgtgac tagttttgga cttttaacct taatgggggt   1500

tgcatgtctc ctattgttaa tcattgtcag ctgcagtgac atgatccaca gtcctgcatt   1560

tactgccttt cacttaatga ttttggacag gttttagaga gccaggatgt tggtctgggc   1620

ctttatttgg ttttggcttt agctgataat gttttagtga tgtcagctag tgcagttctc   1680

aaatggctgc ctattaggga aagaattcag aggatttgac tgctcctaat catctgtcat   1740

tgctgctaga taatgattgg caatttttaa gactcaactg gaaatctcaa cagttgctgg   1800

taaaccatta accataaaaa cgttgctttt gaacaccagt gctgaaaaaa atattttttt   1860

tttttttttt gagagtgaaa agggcttgga cttaagatag gacaatgtgg agaatggggg   1920

gaagaatgca aaacgatata gtatccctta tggatggtac atgtgcaaca gggaactctt   1980

acttcatata ccctttgcag taatcattca gggaggaaga aaaacctgga acttgaatga   2040

aggctgatct ttgttttgtg cactgtggcc ctgccaggca tatagtgaag gtgaatgtct   2100

tctccctcag aaaaaaattg gttccttgct gtcccagtaa ggcatagctt ttccagccct   2160

aactttaaaa ctcagtgagg acttagatgg gaaagaatga ggtaaataca aaggattgca   2220

ggacaacaac tacagcgttg tgtactgtgg gaaggggagt tgggcactct tggaggactc   2280

ctgctgaagg tggtcagcct gcctgacaat ggaagacata cttgaatggg gagcagggta   2340

tgtgctttca tatgaaaaaa gagctgatgt taaaactcat ttggtgaggt caacgttgtc   2400

acataccttc acataaggga tagtatattt tgggttgcag tcaaacttgt gctcagactg   2460

gtgaaactga gagtcaggct tttacatttt aaagaaaata cagttttcat tctaattcag   2520

gtgtctactt attttatgta agaataattt tagatttccc ccccaccatg aagtttcttc   2580

ctattttttt atgctgtaac ttacccccaa tctttatctc tggattttta ctctttaaat   2640

tttgaagttg actagcattt tcaaaccttt attttatacc cttgtctttt atattaactt   2700

tttcttatta ttctttaggt aagaatgatt gatgttggct gatattggag tgctcattca   2760

catgaagtgg atagatactt ctcaagacat cacacagcgt gagtcaatca aggagggaag   2820

ccacaagcag actgacaacg tttctagcag gatcaggtga gctgtgtcca gaaaaccaac   2880

gagaaggagt ggaaggagga atgaacgttt cattctcgtt aataaaggca ttatcctaat   2940

tatccttt                                                            2948


<210>  5807
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  5807

Met Leu Ala Asp Ile Gly Val Leu Ile His Met Lys Trp Ile Asp Thr 
1               5                   10                  15      


Ser Gln Asp Ile Thr Gln Arg Glu Ser Ile Lys Glu Gly Ser His Lys 
            20                  25                  30          


Gln Thr Asp Asn Val Ser Ser Arg Ile Arg 
        35                  40          


<210>  5808
<211>  440
<212>  DNA
<213>  Homosapiens

<400>  5808
tttttactta agaaaatgta ggagaaggtc aggcatggtg gctttacacc tatattccta     60

gcactttggg aggcagaagt gggaggattg cttgagccca gcctgggcaa aatagtgaga    120

ccatgtctct acagaaaaaa atatagccag gtgtggtggt gtgtgcctgt ggtcccagct    180

cccttggagg ctgaggtggg agggatcgct tgatcctggg aggttgaggc tgcagtgagc    240

aagttaacat tttttgttac aggtggatag atacttctca agacatcaca cagcgtgagt    300

caatcaagga gggaagccac aagcagactg acaacgtttc tagcaggatc aggtgagctg    360

tgtccagaaa accaacgaga aggagtggaa ggaggaatga acgtttcatt ctcgttaata    420

aaggcattat cctaattatc                                                440


<210>  5809
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  5809

Gly Cys Ser Glu Gln Val Asn Ile Phe Cys Tyr Arg Trp Ile Asp Thr 
1               5                   10                  15      


Ser Gln Asp Ile Thr Gln Arg Glu Ser Ile Lys Glu Gly Ser His Lys 
            20                  25                  30          


Gln Thr Asp Asn Val Ser Ser Arg Ile Arg 
        35                  40          


<210>  5810
<211>  1328
<212>  DNA
<213>  Homosapiens

<400>  5810
atgtacttgg tatataatat atggacttca ggaactttat tggggtgggg ggttaatttt     60

gccttaccct gttcactttc agatgattag gcttttgcac tttagaatga gaaacttgtg    120

acgttagtgt gttcttacta gctttaattt gtatgtagca atgaattgtg aatcttagtg    180

cagtgggttt ttttaaaaaa ctcaaaaagc tgggaattaa gtggtttcag taataatgct    240

ataccgaggt gcttgcattg tatttcataa ttttgttaca aaccaaaatt atttttaatg    300

agaacagtct tgggttcaga ggtgtgatgc cagaatgtat tttcgtactg ttaggccctt    360

ggaacagata ccggtgcttt ctgaaagatg aaagaaatgc aatgggtgct cttcatgcaa    420

ggttgcaaac ctaccaagaa tgcataatag tctcactttt ccccaataaa gagatgcgtg    480

tgactagttt tggactttta accttaatgg gggttgcatg tctcctattg ttaatcattg    540

tcagctgcag tgacatgatc cacagtcctg catttactgc ctttcactta atgattttgg    600

acaggtttta gagagccagg atgttggtct gggcctttat ttggttttgg ctttagctga    660

taatgtttta gtgatgtcag ctagtgcagt tctcaaatgg ctgcctatta gggaaagaat    720

tcagaggatt tgactgctcc taatcatctg tcattgctgc tagataatga ttggcaattt    780

ttaagactca actggaaatc tcaacagttg ctggtaaacc attaaccata aaaacgttgc    840

ttttgaacac cagtgctgaa aaaaatattt tttttttttt ttttgagagt gaaaagggct    900

tggacttaag ataggacaat gtggagaatg gggggaagaa tgcaaaacga tatagtatcc    960

cttatggatg gtacatgtgc aacagggaac tcttacttca tatacccttt gcagtaatca   1020

ttcagggagg aagaaaaacc tggaacttga atgaaggctg atctttgttt tgtgcactgt   1080

ggccctgcca ggcatatagt gaaggtaaga atgattgatg ttggctgata ttggagtgct   1140

cattcacatg aagtggatag atacttctca agacatcaca cagcgtgagt caatcaagga   1200

gggaagccac aagcagactg acaacgtttc tagcaggatc aggtgagctg tgtccagaaa   1260

accaacgaga aggagtggaa ggaggaatga acgtttcatt ctcgttaata aaggcattat   1320

cctaatta                                                            1328


<210>  5811
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  5811

Met Leu Ala Asp Ile Gly Val Leu Ile His Met Lys Trp Ile Asp Thr 
1               5                   10                  15      


Ser Gln Asp Ile Thr Gln Arg Glu Ser Ile Lys Glu Gly Ser His Lys 
            20                  25                  30          


Gln Thr Asp Asn Val Ser Ser Arg Ile Arg 
        35                  40          


<210>  5812
<211>  1179
<212>  DNA
<213>  Homosapiens

<400>  5812
aagggatgct ggcacagacc ccctaaaata agcttttggt agtactgtac ctttgaagag     60

tggtgaagga tgctaatgga taatctcctg aaagttgtgg cttttgatac ccttactgtg    120

gactgtagag ttgctaaacg ttgtttagca aataatgttg cttagtttca aatgacattt    180

gactttcatc actaaaacag caatgtactc agggttgtaa gcttactcaa atagactttc    240

aataagtctt caatgtatat atgatagttt ttagcctaat gtgaatttaa ataatcttaa    300

tagtttccta aaagtcgatc tgaaacttgg ggtgggaaag gggaggtagc aatttttgaa    360

gtattttagc catttttttc atttaaagaa accacttgtc cccatttcct cttctccact    420

ttctcataat tttgttttaa gaggaacact ggttgttttt tatacttctc ctaatcttta    480

aaaactgcat attgttaaga ccccagtgta tttaataggt attttataag catagcccat    540

tggctcatgt tagtgaaacc ataatcctct ttgcttagaa cattaaactc ataagaagta    600

ctacaaaccc caccactctt tatagatgta ttgtaccact aatataaaca gctaaaaaat    660

ggggaaattg taatgttacg cctgtgcaat ttttaagtgg catattatgg cagattaaaa    720

tttagatact tggcttttct tgggcaagcc actaagttgt ggcggaatgt tttctggtgt    780

tcttggactg caattatgca ctattaaagt agtggcctgc tacataactg catttagcca    840

gcatttctgc agtgcgtaac tgtgaggaac gtagtaccgc aaatggcaat ggacattagg    900

acccggatgt agtattcctg cttgctccaa gattctcatt gccgactgca tacaggtaag    960

aatgattgat gttggctgat attggagtgc tcattcacat gaagtggata gatacttctc   1020

aagacatcac acagcgtgag tcaatcaagg agggaagcca caagcagact gacaacgttt   1080

ctagcaggat caggtgagct gtgtccagaa aaccaacgag aaggagtgga aggaggaatg   1140

aacgtttcat tctcgttaat aaaggcatta tcctaatta                          1179


<210>  5813
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  5813

Met Leu Ala Asp Ile Gly Val Leu Ile His Met Lys Trp Ile Asp Thr 
1               5                   10                  15      


Ser Gln Asp Ile Thr Gln Arg Glu Ser Ile Lys Glu Gly Ser His Lys 
            20                  25                  30          


Gln Thr Asp Asn Val Ser Ser Arg Ile Arg 
        35                  40          


<210>  5814
<211>  1239
<212>  DNA
<213>  Homosapiens

<400>  5814
gggcctggaa ctccagcagg atatggtaga gggagagaag agtacgaagg cccaaacaaa     60

aaaccccgat tttagatgtg atatttaggc tttcattcca gtttgttttg tttttttgtt    120

tagataccaa tcttttaaat tcttgcattt tagtaagaaa gctatctttt tatggatgtt    180

agcagtttat tgacctaata tttgtaaatg gtctgtttgg gcaggtaaaa ttatgtaatg    240

cagtgtttgg aacaggagaa tttttttttc ctttttattt ctttattttt tcttttttac    300

tgtataatgt ccctcaagtt tatggcagtg taccttgtgc cactgaattt ccaaagtgta    360

ccaatttttt tttttttact gtgcttcaaa taaatagaaa aatagttata atattgatct    420

tcaactttgc cattcatgct tctatgcata ttaggctacg tattccacat tgaaagcatg    480

agagtgtcta ggcctttgaa tggcatatgc catttctggg aaatgcatct ggaggctaag    540

tattgctttc tacaaataat tgcccccttt gttttaaaaa gaagaaatgc atattgaagt    600

agtttgatga tttgtttggc atataggaag cacgctggtg ctaagtattt tttaaatggt    660

tatgtaagca aagctgaact gtaaatcttc aggaatatgt attaagattg tggaatgggt    720

gtaagacaat tggtaggggg tgaaagtggg tttgattaaa tggatctttt atggccctat    780

gatctatcct ttacttgaaa gcttttgaaa agtggaaagg tcattttgtt gcatttcccc    840

atttcttgtt tttaaaagac caacaaatct caagccctat aaatggcttg tattgaactt    900

ttacatttga attaaagatg ttaaacatga agtcttttca tgtattcaag tgatttataa    960

agatggggtg tagtctaaaa aacaaaactt gaaagtaaga aggtttagta agtgagccac   1020

tgcgccaggc cgattaataa gatttctttg gtattagttc acttgacagt tatataatgt   1080

tatgtttgag aatttggtaa ctctgattct tgtatccttt ggagtaatca taccctttaa   1140

ttagcaggat caggtgagct gtgtccagaa aaccaacgag aaggagtgga aggaggaatg   1200

aacgtttcat tctcgttaat aaaggcatta tcctaatta                          1239


<210>  5815
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  5815

Met Leu Leu Cys Ile Leu Gly Tyr Val Phe His Ile Glu Ser Met Arg 
1               5                   10                  15      


Val Ser Arg Pro Leu Asn Gly Ile Cys His Phe Trp Glu Met His Leu 
            20                  25                  30          


Glu Ala Lys Tyr Cys Phe Leu Gln Ile Ile Ala Pro Phe Val Leu Lys 
        35                  40                  45              


Arg Arg Asn Ala Tyr 
    50              


<210>  5816
<211>  1031
<212>  DNA
<213>  Homosapiens

<400>  5816
tttttaaaag accaacaaat ctcaagccct ataaatggct tgtattgaac ttttacattt     60

gaattaaaga tgttaaacat gaagtctttt catgtattca agtgatttat aaagatgggg    120

tgtagtctaa aaaacaaaac ttgaaagtaa gaaggtttag taactgggcc gggcgcggtg    180

gctcacgcct gtaatcccag cactttggga ggctgaggtg ggcaaatcat gagatcagga    240

gttcaagacc agcctggcca acatggtgaa accccgtctc tactaaaaat acaaaaaatt    300

agctgggcgt ggtggcaggc gcctgtaatc ccagctactc gggaggctga gccaggagaa    360

ttgcttgaac ctggagatgg aggttgcagt gagctgagac tgccactgca ctccagcctg    420

gacaacagag cgagactctg tctcaaaaaa aaaaaaaggt ttagtactga agtaggttta    480

gttatatata catttgtact ctgtaacttt tacatctcct tgtgctactt ctgttgggca    540

aaatctatag gactataaaa atctattggt tctcttctaa gagctagtgg tgattgttaa    600

caaatagggt tgcagataat cattcttatt gtaaatttaa cttgttttca catagtttcg    660

ttttcatgta gcactaaatc tggagaaagt tgctcatgct acacagtaca aatatccctt    720

cctcccacca taaaggcttg gaatgtttcc atggtgttgt cagttaattg tcaacttcat    780

tgaaccccct tccattagaa caagagactt tgactattaa agtagattgt ttattgttgc    840

ctgttagtat aatgggagcc tgatttccca gtgtaaatat gttagaggaa cagcttccta    900

acagtaggta aagtaattga atggtttggc tttgttctga gttacgttcc attcaaatct    960

gtacattgta gaattcttac tatggaatga atgaacgttt cattctcgtt aataaaggca   1020

ttatcctaat t                                                        1031


<210>  5817
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  5817

Met Arg Ser Gly Val Gln Asp Gln Pro Gly Gln His Gly Glu Thr Pro 
1               5                   10                  15      


Ser Leu Leu Lys Ile Gln Lys Ile Ser Trp Ala Trp Trp Gln Ala Pro 
            20                  25                  30          


Val Ile Pro Ala Thr Arg Glu Ala Glu Pro Gly Glu Leu Leu Glu Pro 
        35                  40                  45              


Gly Asp Gly Gly Cys Ser Glu Leu Arg Leu Pro Leu His Ser Ser Leu 
    50                  55                  60                  


Asp Asn Arg Ala Arg Leu Cys Leu Lys Lys Lys Lys Arg Phe Ser Thr 
65                  70                  75                  80  


Glu Val Gly Leu Val Ile Tyr Thr Phe Val Leu Cys Asn Phe Tyr Ile 
                85                  90                  95      


Ser Leu Cys Tyr Phe Cys Trp Ala Lys Ser Ile Gly Leu 
            100                 105                 


<210>  5818
<211>  1292
<212>  DNA
<213>  Homosapiens

<400>  5818
gctagtgcag ttctcaaatg gctgcctatt agggaaagaa ttcagaggat ttgactgctc     60

ctaatcatct gtcattgctg ctagataatg attggcaatt tttaagactc aactggaaat    120

ctcaacagtt gctggtaaac cattaaccat aaaaacgttg cttttgaaca ccagtgctga    180

aaaaaatatt tttttttttt tttttgagag tgaaaagggc ttggacttaa gataggacaa    240

tgtggagaat ggggggaaga atgcaaaacg atatagtatc ccttatggat ggtacatgtg    300

caacagggaa ctcttacttc atataccctt tgcagtaatc attcagggag gaagaaaaac    360

ctggaacttg aatgaaggct gatctttgtt ttgtgcactg tggccctgcc aggcatatag    420

tgaaggtgaa tgtcttctcc ctcagaaaaa aattggttcc ttgctgtccc agtaaggcat    480

agcttttcca gccctaactt taaaactcag tgaggactta gatgggaaag aatgaggtaa    540

atacaaagga ttgcaggaca acaactacag cgttgtgtac tgtgggaagg ggagttgggc    600

actcttggag gactcctgct gaaggtggtc agcctgcctg acaatggaag acatacttga    660

atggggagca gggtatgtgc tttcatatga aaaaagagct gatgttaaaa ctcatttggt    720

gaggtcaacg ttgtcacata ccttcacata agggatagta tattttgggt tgcagtcaaa    780

cttgtgctca gactggtgaa actgagagtc aggcttttac attttaaaga aaatacagtt    840

ttcattctaa ttcaggtgtc tacttatttt atgtaagaat aattttagat ttccccccca    900

ccatgaagtt tcttcctatt tttttatgct gtaacttacc cccaatcttt atctctggat    960

ttttactctt taaattttga agttgactag cattttcaaa cctttatttt atacccttgt   1020

cttttatatt aactttttct tattattctt taggtaagaa tgattgatgt tggctgatat   1080

tggagtgctc attcacatga agtggataga tacttctcaa gacatcacac agcgtgagtc   1140

aatcaaggag ggaagccaca agcagactga caacgtttct aggtaagtta aatgattctt   1200

agtctgttaa actgtcttca gaaaggccct tgggtggtac aaaaataaca atactaatgt   1260

gggaaccatt aattttttat tttttgagat gg                                 1292


<210>  5819
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  5819

Met Leu Ala Asp Ile Gly Val Leu Ile His Met Lys Trp Ile Asp Thr 
1               5                   10                  15      


Ser Gln Asp Ile Thr Gln Arg Glu Ser Ile Lys Glu Gly Ser His Lys 
            20                  25                  30          


Gln Thr Asp Asn Val Ser Arg 
        35                  


<210>  5820
<211>  7153
<212>  DNA
<213>  Homosapiens

<400>  5820
ggtttttttt ttggagagag ttttgctctt gtcacccagg ctggagtgca gtggcttgat     60

cttggctcac tgcagcatct gccttctggg ttcaagtgat tctcctgcct cagcctcttg    120

agtaggtggg attacaagtg cctgccatca ggctcggcta atttttgtat ttttagtaga    180

aatggcgttt cgccttgttg gccaggctgg tcttgaactc ctgacctcag gtgatctgcc    240

tgcctcggcc ttccaaagtg ctgtgattac aggcgtgagc cactgctccc ggccttgaat    300

aggaagtttt gtaggtcttt ggataattga gtctaactta gttttcagaa tattgatttc    360

aaaaataatt cacatgatga acttttgaac tttaccatgt tttttattta actcttgaaa    420

atttctcagt tcttaagaat gcttgctgtg ggtatagtgc aggtatattg aaaggaattt    480

ttttcttgca gcgggaaaga gacatgcgaa tgggtggcgg aggagcaatg aacatgggag    540

gtaagtcgta ctgagcgctt tgggcaggga ggtgcggggc ctgtgggtgg acagggtcct    600

agaggaatgg ggcctggaac tccagcagga tatggtagag ggagagaaga gtacgaaggc    660

ccaaacaaaa aaccccgatt ttagatgtga tatttaggct ttcattccag tttgttttgt    720

ttttttgttt agataccaat cttttaaatt cttgcatttt agtaagaaag ctatcttttt    780

atggatgtta gcagtttatt gacctaatat ttgtaaatgg tctgtttggg caggtaaaat    840

tatgtaatgc agtgtttgga acaggagaat ttttttttcc tttttatttc tttatttttt    900

cttttttact gtataatgtc cctcaagttt atggcagtgt accttgtgcc actgaatttc    960

caaagtgtac caattttttt ttttttactg tgcttcaaat aaatagaaaa atagttataa   1020

tattgatctt caactttgcc attcatgctt ctatgcatat taggctacgt attccacatt   1080

gaaagcatga gagtgtctag gcctttgaat ggcatatgcc atttctggga aatgcatctg   1140

gaggctaagt attgctttct acaaataatt gccccctttg ttttaaaaag aagaaatgca   1200

tattgaagta gtttgatgat ttgtttggca tataggaagc acgctggtgc taagtatttt   1260

ttaaatggtt atgtaagcaa agctgaactg taaatcttca ggaatatgta ttaagattgt   1320

ggaatgggtg taagacaatt ggtagggggt gaaagtgggt ttgattaaat ggatctttta   1380

tggccctatg atctatcctt tacttgaaag cttttgaaaa gtggaaaggt cattttgttg   1440

catttcccca tttcttgttt ttaaaagacc aacaaatctc aagccctata aatggcttgt   1500

attgaacttt tacatttgaa ttaaagatgt taaacatgaa gtcttttcat gtattcaagt   1560

gatttataaa gatggggtgt agtctaaaaa acaaaacttg aaagtaagaa ggtttagtaa   1620

ctgggccggg cgcggtggct cacgcctgta atcccagcac tttgggaggc tgaggtgggc   1680

aaatcatgag atcaggagtt caagaccagc ctggccaaca tggtgaaacc ccgtctctac   1740

taaaaataca aaaaattagc tgggcgtggt ggcaggcgcc tgtaatccca gctactcggg   1800

aggctgagcc aggagaattg cttgaacctg gagatggagg ttgcagtgag ctgagactgc   1860

cactgcactc cagcctggac aacagagcga gactctgtct caaaaaaaaa aaaaggttta   1920

gtactgaagt aggtttagtt atatatacat ttgtactctg taacttttac atctccttgt   1980

gctacttctg ttgggcaaaa tctataggac tataaaaatc tattggttct cttctaagag   2040

ctagtggtga ttgttaacaa atagggttgc agataatcat tcttattgta aatttaactt   2100

gttttcacat agtttcgttt tcatgtagca ctaaatctgg agaaagttgc tcatgctaca   2160

cagtacaaat atcccttcct cccaccataa aggcttggaa tgtttccatg gtgttgtcag   2220

ttaattgtca acttcattga acccccttcc attagaacaa gagactttga ctattaaagt   2280

agattgttta ttgttgcctg ttagtataat gggagcctga tttcccagtg taaatatgtt   2340

agaggaacag cttcctaaca gtaggtaaag taattgaatg gtttggcttt gttctgagtt   2400

acgttccatt caaatctgta cattgtagaa ttcttactat ggaatgtgtc ttcctccttt   2460

tcacctcttt tcttggtgct aattggcaaa agaaaaattc taagtcaaac ctttattaac   2520

atgctgaagt ttagtattgt gcctgtgtac aaaaggagac ctattgttgg aacaatctga   2580

gcactttctg cataggaaac aggataatgc tgaaagtaaa cactagtgta taaaagcatc   2640

tcaccaaata ctggttgtat gactgacagg tacatggtgt gctaagggag agaatctcat   2700

tagaaagtaa tgctcattat atcattcacc agcacactcg gaaatatgag tagttttacc   2760

atgattatat cagtgaggaa gttttgtccc caaacaggtt attaattggt gatacataag   2820

agattttctg tacggaaaca agggtcttga ttagaaagga atccattaca gtttggttga   2880

attatatagt agggactcta ctaaagacaa gaaaataagg ggtgttccat gggacaccca   2940

cagagggtga actttgaatg tgtgtgggtg ggggctggtc gggaaatggg aaaatctgcc   3000

tataaaatta atgtttcagt ttatttttca gattacatgc ctttctttat aagggatgct   3060

ggcacagacc ccctaaaata agcttttggt agtactgtac ctttgaagag tggtgaagga   3120

tgctaatgga taatctcctg aaagttgtgg cttttgatac ccttactgtg gactgtagag   3180

ttgctaaacg ttgtttagca aataatgttg cttagtttca aatgacattt gactttcatc   3240

actaaaacag caatgtactc agggttgtaa gcttactcaa atagactttc aataagtctt   3300

caatgtatat atgatagttt ttagcctaat gtgaatttaa ataatcttaa tagtttccta   3360

aaagtcgatc tgaaacttgg ggtgggaaag gggaggtagc aatttttgaa gtattttagc   3420

catttttttc atttaaagaa accacttgtc cccatttcct cttctccact ttctcataat   3480

tttgttttaa gaggaacact ggttgttttt tatacttctc ctaatcttta aaaactgcat   3540

attgttaaga ccccagtgta tttaataggt attttataag catagcccat tggctcatgt   3600

tagtgaaacc ataatcctct ttgcttagaa cattaaactc ataagaagta ctacaaaccc   3660

caccactctt tatagatgta ttgtaccact aatataaaca gctaaaaaat ggggaaattg   3720

taatgttacg cctgtgcaat ttttaagtgg catattatgg cagattaaaa tttagatact   3780

tggcttttct tgggcaagcc actaagttgt ggcggaatgt tttctggtgt tcttggactg   3840

caattatgca ctattaaagt agtggcctgc tacataactg catttagcca gcatttctgc   3900

agtgcgtaac tgtgaggaac gtagtaccgc aaatggcaat ggacattagg acccggatgt   3960

agtattcctg cttgctccaa gattctcatt gccgactgca tacaggtagg taacaagcaa   4020

tataatctaa cttggtgact tgtatgtact tttattccgt gggcattctg gcatcacatt   4080

tctgacaatg aaattacagt gcagcaccta acacttgtat ggtaaagcta gcttacatca   4140

aaactgtgtg ggtgtggggt tagagctgta atttgtcagg cagaattcag tgctgttgca   4200

gttctcagat aaaaagtgca aacttgattc tttggtatat ctgactcagt tgtgtggttt   4260

cctttagttg cattgtaact gaagataaca tggaacacat cagtggtgtg ggggagaggg   4320

aactaaacta tacttgggaa ctagggtgct tttagcacct tgacatggac cgtatagcat   4380

gtgataatta gtctctattg tagcaaactg acctgcccat agatcggcaa tatcagtaat   4440

ttcattatgc aatcttggta attctacaag ttgagttgaa ctaaaagtac aggttttttt   4500

gtaatgcgat ttaaaatttt taaaaacatg ggcttcatga aaacaccatt gttactaact   4560

tgggcttaga tgggaatcta atgtgaatag ttcaagttat gggacttgtc taaatgtgtc   4620

tatactctaa acctggggga aggtggtgtg gaacattgac ttgactacag tcgaatacat   4680

gttgggaatc attcccaatc ataagacatc gtcgtttctg taggatgact gcatatgttc   4740

agagtagctt tttgaatttg gttcccttag ctttagggat gtgatgttat agtccaaaat   4800

gtttacaaga aaacctaagt cttcaaaagc acaacttttg ttgcttagga ctttgcatca   4860

actgttgttc cagacctcac ttcaacttct tggtctctga actggtttta gctagcatgc   4920

atgagagaca gttttcatgt ataatgtttc tgctctgtaa ctggaaagtg gtttactttg   4980

cataaatgct gatgaaaact tcatgactat gagacttttc ttctgtgtat caagaaaaag   5040

cttgctcgtt ggcaagcaat tcacaaggtg gggacagact tgtactttaa catgtagtcc   5100

attcaagcaa acaactttgg actctactga tagatgaaag agcaaatgat gactagttta   5160

gcctctgcat atcaacaata taatgcagat caagtataat gctcaatatt agtgacatga   5220

gtatcactaa attacataga accctgatgg ggtttcctgt gtcgtaatcc attaaatcgg   5280

tggccagtgc ttgctgccgt ggtttagtga ttgggtgtta gaaataaaaa ctcaggtcta   5340

tttcttacca gtcagtaaca atttttagag aatgtacttg gtatataata tatggacttc   5400

aggaacttta ttggggtggg gggttaattt tgccttaccc tgttcacttt cagatgatta   5460

ggcttttgca ctttagaatg agaaacttgt gacgttagtg tgttcttact agctttaatt   5520

tgtatgtagc aatgaattgt gaatcttagt gcagtgggtt tttttaaaaa actcaaaaag   5580

ctgggaatta agtggtttca gtaataatgc tataccgagg tgcttgcatt gtatttcata   5640

attttgttac aaaccaaaat tatttttaat gagaacagtc ttgggttcag aggtgtgatg   5700

ccagaatgta ttttcgtact gttaggccct tggaacagat accggtgctt tctgaaagat   5760

gaaagaaatg caatgggtgc tcttcatgca aggttgcaaa cctaccaaga atgcataata   5820

gtctcacttt tccccaataa agagatgcgt gtgactagtt ttggactttt aaccttaatg   5880

ggggttgcat gtctcctatt gttaatcatt gtcagctgca gtgacatgat ccacagtcct   5940

gcatttactg cctttcactt aatgattttg gacaggtttt agagagccag gatgttggtc   6000

tgggccttta tttggttttg gctttagctg ataatgtttt agtgatgtca gctagtgcag   6060

ttctcaaatg gctgcctatt agggaaagaa ttcagaggat ttgactgctc ctaatcatct   6120

gtcattgctg ctagataatg attggcaatt tttaagactc aactggaaat ctcaacagtt   6180

gctggtaaac cattaaccat aaaaacgttg cttttgaaca ccagtgctga aaaaaatatt   6240

tttttttttt tttttgagag tgaaaagggc ttggacttaa gataggacaa tgtggagaat   6300

ggggggaaga atgcaaaacg atatagtatc ccttatggat ggtacatgtg caacagggaa   6360

ctcttacttc atataccctt tgcagtaatc attcagggag gaagaaaaac ctggaacttg   6420

aatgaaggct gatctttgtt ttgtgcactg tggccctgcc aggcatatag tgaaggtgaa   6480

tgtcttctcc ctcagaaaaa aattggttcc ttgctgtccc agtaaggcat agcttttcca   6540

gccctaactt taaaactcag tgaggactta gatgggaaag aatgaggtaa atacaaagga   6600

ttgcaggaca acaactacag cgttgtgtac tgtgggaagg ggagttgggc actcttggag   6660

gactcctgct gaaggtggtc agcctgcctg acaatggaag acatacttga atggggagca   6720

gggtatgtgc tttcatatga aaaaagagct gatgttaaaa ctcatttggt gaggtcaacg   6780

ttgtcacata ccttcacata agggatagta tattttgggt tgcagtcaaa cttgtgctca   6840

gactggtgaa actgagagtc aggcttttac attttaaaga aaatacagtt ttcattctaa   6900

ttcaggtgtc tacttatttt atgtaagaat aattttagat ttccccccca ccatgaagtt   6960

tcttcctatt tttttatgct gtaacttacc cccaatcttt atctctggat ttttactctt   7020

taaattttga agttgactag cattttcaaa cctttatttt atacccttgt cttttatatt   7080

aactttttct tattattctt taggtaagaa tgattgatgt tggctgatat tggagtgctc   7140

attcacatga agt                                                      7153


<210>  5821
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  5821

Met Arg Ser Gly Val Gln Asp Gln Pro Gly Gln His Gly Glu Thr Pro 
1               5                   10                  15      


Ser Leu Leu Lys Ile Gln Lys Ile Ser Trp Ala Trp Trp Gln Ala Pro 
            20                  25                  30          


Val Ile Pro Ala Thr Arg Glu Ala Glu Pro Gly Glu Leu Leu Glu Pro 
        35                  40                  45              


Gly Asp Gly Gly Cys Ser Glu Leu Arg Leu Pro Leu His Ser Ser Leu 
    50                  55                  60                  


Asp Asn Arg Ala Arg Leu Cys Leu Lys Lys Lys Lys Arg Phe Ser Thr 
65                  70                  75                  80  


Glu Val Gly Leu Val Ile Tyr Thr Phe Val Leu Cys Asn Phe Tyr Ile 
                85                  90                  95      


Ser Leu Cys Tyr Phe Cys Trp Ala Lys Ser Ile Gly Leu 
            100                 105                 


<210>  5822
<211>  1538
<212>  DNA
<213>  Homosapiens

<400>  5822
ggtttttttt ttggagagag ttttgctctt gtcacccagg ctggagtgca gtggcttgat     60

cttggctcac tgcagcatct gccttctggg ttcaagtgat tctcctgcct cagcctcttg    120

agtaggtggg attacaagtg cctgccatca ggctcggcta atttttgtat ttttagtaga    180

aatggcgttt cgccttgttg gccaggctgg tcttgaactc ctgacctcag gtgatctgcc    240

tgcctcggcc ttccaaagtg ctgtgattac aggcgtgagc cactgctccc ggccttgaat    300

aggaagtttt gtaggtcttt ggataattga gtctaactta gttttcagaa tattgatttc    360

aaaaataatt cacatgatga acttttgaac tttaccatgt tttttattta actcttgaaa    420

atttctcagt tcttaagaat gcttgctgtg ggtatagtgc aggtatattg aaaggaattt    480

ttttcttgca gcgggaaaga gacatgcgaa tgggtggcgg aggagcaatg aacatgggag    540

gtaagtcgta ctgagcgctt tgggcaggga ggtgcggggc ctgtgggtgg acagggtcct    600

agaggaatgg ggcctggaac tccagcagga tatggtagag ggagagaaga gtacgaaggc    660

ccaaacaaaa aaccccgatt ttagatgtga tatttaggct ttcattccag tttgttttgt    720

ttttttgttt agataccaat cttttaaatt cttgcatttt agtaagaaag ctatcttttt    780

atggatgtta gcagtttatt gacctaatat ttgtaaatgg tctgtttggg caggtaaaat    840

tatgtaatgc agtgtttgga acaggagaat ttttttttcc tttttatttc tttatttttt    900

cttttttact gtataatgtc cctcaagttt atggcagtgt accttgtgcc actgaatttc    960

caaagtgtac caattttttt ttttttactg tgcttcaaat aaatagaaaa atagttataa   1020

tattgatctt caactttgcc attcatgctt ctatgcatat taggctacgt attccacatt   1080

gaaagcatga gagtgtctag gcctttgaat ggcatatgcc atttctggga aatgcatctg   1140

gaggctaagt attgctttct acaaataatt gccccctttg ttttaaaaag aagaaatgca   1200

tattgaagta gtttgatgat ttgtttggca tataggaagc acgctggtgc taagtatttt   1260

ttaaatggtt atgtaagcaa agctgaactg taaatcttca ggaatatgta ttaagattgt   1320

ggaatgggtg taagacaatt ggtagggggt gaaagtgggt ttgattaaat ggatctttta   1380

tggccctatg atctatcctt tacttgaaag cttttgaaaa gtggaaaggt cattttgttg   1440

catttcccca tttcttgttt ttaaaagacc aacaaatctc aagccctata aatggcttgt   1500

attgaacttt tacatttgaa ttaaagatgt taaacatg                           1538


<210>  5823
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  5823

Met Leu Leu Cys Ile Leu Gly Tyr Val Phe His Ile Glu Ser Met Arg 
1               5                   10                  15      


Val Ser Arg Pro Leu Asn Gly Ile Cys His Phe Trp Glu Met His Leu 
            20                  25                  30          


Glu Ala Lys Tyr Cys Phe Leu Gln Ile Ile Ala Pro Phe Val Leu Lys 
        35                  40                  45              


Arg Arg Asn Ala Tyr 
    50              


<210>  5824
<211>  1276
<212>  DNA
<213>  Homosapiens

<400>  5824
catgtttaac atctttaatt caaatgtaaa agttcaatac aagccattta tagggcttga     60

gatttgttgg tcttttaaaa acaagaaatg gggaaatgca acaaaatgac ctttccactt    120

ttcaaaagct ttcaagtaaa ggatagatca tagggccata aaagatccat ttaatcaaac    180

ccactttcac cccctaccaa ttgtcttaca cccattccac aatcttaata catattcctg    240

aagatttaca gttcagcttt gcttacataa ccatttaaaa aatacttagc accagcgtgc    300

ttcctatatg ccaaacaaat catcaaacta cttcaatatg catttcttct ttttaaaaca    360

aagggggcaa ttatttgtag aaagcaatac ttagcctcca gatgcatttc ccagaaatgg    420

catatgccat tcaaaggcct agacactctc atgctttcaa tgtggaatac gtagcctaat    480

atgcatagaa gcatgaatgg caaagttgaa gatcaatatt ataactattt ttctatttat    540

ttgaagcaca gtaaaaaaaa aaaaattggt acactttgga aattcagtgg cacaaggtac    600

actgccataa acttgaggga cattatacag taaaaaagaa aaaataaaga aataaaaagg    660

aaaaaaaaat tctcctgttc caaacactgc attacataat tttacctgcc caaacagacc    720

atttacaaat attaggtcaa taaactgcta acatccataa aaagatagct ttcttactaa    780

aatgcaagaa tttaaaagat tggtatctaa acaaaaaaac aaaacaaact ggaatgaaag    840

cctaaatatc acatctaaaa tcggggtttt ttgtttgggc cttcgtactc ttctctccct    900

ctaccatatc ctgctggagt tccaggcccc attcctctag gacctggccc ggaccctggc    960

ggggcccccg aggttggtgg agtggcgggc ggggccgagc tggaggctgg tggtgcgctg   1020

cctactccgg gagcggggcc gggtccctga gcaacgacgg gcttggaaga gtcctgcggc   1080

ggtggcggcg gctgctgctg ctgatgcggc tgtggatgcg gcggcggctg atgcggtggc   1140

ggctgctgcg gcggtggctg ctgcggtggt ggctgttgct gctgttggtg tggaggcggt   1200

ggcgggatcg gaggcttagg gccgctctgg cccgggccag gacccatggg gccgcgattc   1260

tgattgaggc ccatgc                                                   1276


<210>  5825
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  5825

Met Arg Leu Trp Met Arg Arg Arg Leu Met Arg Trp Arg Leu Leu Arg 
1               5                   10                  15      


Arg Trp Leu Leu Arg Trp Trp Leu Leu Leu Leu Leu Val Trp Arg Arg 
            20                  25                  30          


Trp Arg Asp Arg Arg Leu Arg Ala Ala Leu Ala Arg Ala Arg Thr His 
        35                  40                  45              


Gly Ala Ala Ile Leu Ile Glu Ala 
    50                  55      


<210>  5826
<211>  3077
<212>  DNA
<213>  Homosapiens

<400>  5826
gccgcctgtg tcatccgcca ttttgtgaga agcaaggtgg cctccacgtt tcctgagcgt     60

cttcttcgct tttgcctcga ccgccccttg accacagaca tgtctcggga tcggttccgg    120

agtcgtggcg gtggcggtgg tggcttccac aggcgtggag gaggcggcgg ccgcggcggc    180

ctccacgact tccgttctcc gccgcccggc atgggcctca atcagaatcg cggccccatg    240

ggtcctggcc cgggccagag cggccctaag cctccgatcc cgccaccgcc tccacaccaa    300

cagcagcaac agccaccacc gcagcagcca ccgccgcagc agccgccacc gcatcagccg    360

ccgccgcatc cacagccgca tcagcagcag cagccgccgc caccgccgca ggactcttcc    420

aagcccgtcg ttgctcaggg acccggcccc gctcccggag taggcagcgc accaccagcc    480

tccagctcgg ccccgcccgc cactccacca acctcggggg ccccgccagg gtccgggcca    540

ggcccgactc cgaccccgcc gcctgcagtc acctcggccc ctcccggggc gccgccaccc    600

accccgccaa gcagcggggt ccctaccaca cctcctcagg ccggaggccc gccgcctccg    660

cccgcggcag tcccgggccc gggtccaggg cctaagcagg gcccaggtcc gggtggtccc    720

aaaggcggca aaatgcctgg cgggccgaag ccaggtggcg gcccgggcct aagtacgcct    780

ggcggccacc ccaagccgcc gcatcgaggc ggcggggagc cccgcggggg ccgccagcac    840

cacccgccct accaccagca gcatcaccag gggcccccgc ccggcgggcc cggcggccgc    900

agcgaggaga agatctcgga ctcggagggg tttaaagcca atttgtctct cttgaggagg    960

cctggagaga aaacttacac acagcgatgt cggttgtttg ttgggaatct acctgctgat   1020

atcacggagg atgaattcaa aagactattt gctaaatatg gagaaccagg agaagttttt   1080

atcaacaaag gcaaaggatt cggatttatt aagcttgaat ctagagcttt ggctgaaatt   1140

gccaaagccg aactggatga tacacccatg agaggtagac agcttcgagt tcgctttgcc   1200

acacatgctg ctgccctttc tgttcgtaat ctttcacctt atgtttccaa tgaactgttg   1260

gaagaagcct ttagccaatt tggtcctatt gaaagggctg ttgtaatagt ggatgatcgt   1320

ggaagatcta cagggaaagg cattgttgaa tttgcttcta agccagcagc aagaaaggca   1380

tttgaacgat gcagtgaagg tgttttctta ctgacgacaa ctcctcgtcc agtcattgtg   1440

gaaccacttg aacaactaga tgatgaagat ggtcttcctg aaaaacttgc ccagaagaat   1500

ccaatgtatc aaaaggagag agaaacccct cctcgttttg cccagcatgg cacgtttgag   1560

tacgaatatt ctcagcgatg gaagtctttg gatgaaatgg aaaaacagca aagggaacaa   1620

gttgaaaaaa acatgaaaga tgcaaaagac aaattggaaa gtgaaatgga agatgcctat   1680

catgaacatc aggcaaatct tttgcgccaa gatctgatga gacgacagga agaattaaga   1740

cgcatggaag aacttcacaa tcaagaaatg cagaaacgta aagaaatgca attgaggcaa   1800

gaggaggaac gacgtagaag agaggaagag atgatgattc gtcaacgtga gatggaagaa   1860

caaatgaggc gccaaagaga ggaaagttac agccgaatgg gctacatgga tccacgggaa   1920

agagacatgc gaatgggtgg cggaggagca atgaacatgg gagatcccta tggttcagga   1980

ggccagaaat ttccacctct aggaggtggt ggtggcatag gttatgaagc taatcctggc   2040

gttccaccag caaccatgag tggttccatg atgggaagtg acatgcgtac tgagcgcttt   2100

gggcagggag gtgcggggcc tgtgggtgga cagggtccta gaggaatggg gcctggaact   2160

ccagcaggat atggtagagg gagagaagag tacgaaggcc caaacaaaaa accccgattt   2220

tagatgtgat atttaggctt tcattccagt ttgttttgtt tttttgttta gataccaatc   2280

ttttaaattc ttgcatttta gtaagaaagc tatcttttta tggatgttag cagtttattg   2340

acctaatatt tgtaaatggt ctgtttgggc aggtaaaatt atgtaatgca gtgtttggaa   2400

caggagaatt tttttttcct ttttatttct ttattttttc ttttttactg tataatgtcc   2460

ctcaagttta tggcagtgta ccttgtgcca ctgaatttcc aaagtgtacc aatttttttt   2520

tttttactgt gcttcaaata aatagaaaaa tagttataat attgatcttc aactttgcca   2580

ttcatgcttc tatgcatatt aggctacgta ttccacattg aaagcatgag agtgtctagg   2640

cctttgaatg gcatatgcca tttctgggaa atgcatctgg aggctaagta ttgctttcta   2700

caaataattg ccccctttgt tttaaaaaga agaaatgcat attgaagtag tttgatgatt   2760

tgtttggcat ataggaagca cgctggtgct aagtattttt taaatggtta tgtaagcaaa   2820

gctgaactgt aaatcttcag gaatatgtat taagattgtg gaatgggtgt aagacaattg   2880

gtagggggtg aaagtgggtt tgattaaatg gatcttttat ggccctatga tctatccttt   2940

acttgaaagc ttttgaaaag tggaaaggtc attttgttgc atttccccat ttcttgtttt   3000

taaaagacca acaaatctca agccctataa atggcttgta ttgaactttt acatttgaat   3060

taaagatgtt aaacatg                                                  3077


<210>  5827
<211>  707
<212>  PRT
<213>  Homosapiens

<400>  5827

Met Ser Arg Asp Arg Phe Arg Ser Arg Gly Gly Gly Gly Gly Gly Phe 
1               5                   10                  15      


His Arg Arg Gly Gly Gly Gly Gly Arg Gly Gly Leu His Asp Phe Arg 
            20                  25                  30          


Ser Pro Pro Pro Gly Met Gly Leu Asn Gln Asn Arg Gly Pro Met Gly 
        35                  40                  45              


Pro Gly Pro Gly Gln Ser Gly Pro Lys Pro Pro Ile Pro Pro Pro Pro 
    50                  55                  60                  


Pro His Gln Gln Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Gln 
65                  70                  75                  80  


Gln Pro Pro Pro His Gln Pro Pro Pro His Pro Gln Pro His Gln Gln 
                85                  90                  95      


Gln Gln Pro Pro Pro Pro Pro Gln Asp Ser Ser Lys Pro Val Val Ala 
            100                 105                 110         


Gln Gly Pro Gly Pro Ala Pro Gly Val Gly Ser Ala Pro Pro Ala Ser 
        115                 120                 125             


Ser Ser Ala Pro Pro Ala Thr Pro Pro Thr Ser Gly Ala Pro Pro Gly 
    130                 135                 140                 


Ser Gly Pro Gly Pro Thr Pro Thr Pro Pro Pro Ala Val Thr Ser Ala 
145                 150                 155                 160 


Pro Pro Gly Ala Pro Pro Pro Thr Pro Pro Ser Ser Gly Val Pro Thr 
                165                 170                 175     


Thr Pro Pro Gln Ala Gly Gly Pro Pro Pro Pro Pro Ala Ala Val Pro 
            180                 185                 190         


Gly Pro Gly Pro Gly Pro Lys Gln Gly Pro Gly Pro Gly Gly Pro Lys 
        195                 200                 205             


Gly Gly Lys Met Pro Gly Gly Pro Lys Pro Gly Gly Gly Pro Gly Leu 
    210                 215                 220                 


Ser Thr Pro Gly Gly His Pro Lys Pro Pro His Arg Gly Gly Gly Glu 
225                 230                 235                 240 


Pro Arg Gly Gly Arg Gln His His Pro Pro Tyr His Gln Gln His His 
                245                 250                 255     


Gln Gly Pro Pro Pro Gly Gly Pro Gly Gly Arg Ser Glu Glu Lys Ile 
            260                 265                 270         


Ser Asp Ser Glu Gly Phe Lys Ala Asn Leu Ser Leu Leu Arg Arg Pro 
        275                 280                 285             


Gly Glu Lys Thr Tyr Thr Gln Arg Cys Arg Leu Phe Val Gly Asn Leu 
    290                 295                 300                 


Pro Ala Asp Ile Thr Glu Asp Glu Phe Lys Arg Leu Phe Ala Lys Tyr 
305                 310                 315                 320 


Gly Glu Pro Gly Glu Val Phe Ile Asn Lys Gly Lys Gly Phe Gly Phe 
                325                 330                 335     


Ile Lys Leu Glu Ser Arg Ala Leu Ala Glu Ile Ala Lys Ala Glu Leu 
            340                 345                 350         


Asp Asp Thr Pro Met Arg Gly Arg Gln Leu Arg Val Arg Phe Ala Thr 
        355                 360                 365             


His Ala Ala Ala Leu Ser Val Arg Asn Leu Ser Pro Tyr Val Ser Asn 
    370                 375                 380                 


Glu Leu Leu Glu Glu Ala Phe Ser Gln Phe Gly Pro Ile Glu Arg Ala 
385                 390                 395                 400 


Val Val Ile Val Asp Asp Arg Gly Arg Ser Thr Gly Lys Gly Ile Val 
                405                 410                 415     


Glu Phe Ala Ser Lys Pro Ala Ala Arg Lys Ala Phe Glu Arg Cys Ser 
            420                 425                 430         


Glu Gly Val Phe Leu Leu Thr Thr Thr Pro Arg Pro Val Ile Val Glu 
        435                 440                 445             


Pro Leu Glu Gln Leu Asp Asp Glu Asp Gly Leu Pro Glu Lys Leu Ala 
    450                 455                 460                 


Gln Lys Asn Pro Met Tyr Gln Lys Glu Arg Glu Thr Pro Pro Arg Phe 
465                 470                 475                 480 


Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr Ser Gln Arg Trp Lys Ser 
                485                 490                 495     


Leu Asp Glu Met Glu Lys Gln Gln Arg Glu Gln Val Glu Lys Asn Met 
            500                 505                 510         


Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu Met Glu Asp Ala Tyr His 
        515                 520                 525             


Glu His Gln Ala Asn Leu Leu Arg Gln Asp Leu Met Arg Arg Gln Glu 
    530                 535                 540                 


Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Met Gln Lys Arg 
545                 550                 555                 560 


Lys Glu Met Gln Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu Glu 
                565                 570                 575     


Glu Met Met Ile Arg Gln Arg Glu Met Glu Glu Gln Met Arg Arg Gln 
            580                 585                 590         


Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr Met Asp Pro Arg Glu Arg 
        595                 600                 605             


Asp Met Arg Met Gly Gly Gly Gly Ala Met Asn Met Gly Asp Pro Tyr 
    610                 615                 620                 


Gly Ser Gly Gly Gln Lys Phe Pro Pro Leu Gly Gly Gly Gly Gly Ile 
625                 630                 635                 640 


Gly Tyr Glu Ala Asn Pro Gly Val Pro Pro Ala Thr Met Ser Gly Ser 
                645                 650                 655     


Met Met Gly Ser Asp Met Arg Thr Glu Arg Phe Gly Gln Gly Gly Ala 
            660                 665                 670         


Gly Pro Val Gly Gly Gln Gly Pro Arg Gly Met Gly Pro Gly Thr Pro 
        675                 680                 685             


Ala Gly Tyr Gly Arg Gly Arg Glu Glu Tyr Glu Gly Pro Asn Lys Lys 
    690                 695                 700                 


Pro Arg Phe 
705         


<210>  5828
<211>  1031
<212>  DNA
<213>  Homosapiens

<400>  5828
ggtttttttt ttggagagag ttttgctctt gtcacccagg ctggagtgca gtggcttgat     60

cttggctcac tgcagcatct gccttctggg ttcaagtgat tctcctgcct cagcctcttg    120

agtaggtggg attacaagtg cctgccatca ggctcggcta atttttgtat ttttagtaga    180

aatggcgttt cgccttgttg gccaggctgg tcttgaactc ctgacctcag gtgatctgcc    240

tgcctcggcc ttccaaagtg ctgtgattac aggcgtgagc cactgctccc ggccttgaat    300

aggaagtttt gtaggtcttt ggataattga gtctaactta gttttcagaa tattgatttc    360

aaaaataatt cacatgatga acttttgaac tttaccatgt tttttattta actcttgaaa    420

atttctcagt tcttaagaat gcttgctgtg ggtatagtgc aggtatattg aaaggaattt    480

ttttcttgca gcgggaaaga gacatgcgaa tgggtggcgg aggagcaatg aacatgggag    540

gtaagtcgta ctgagcgctt tgggcaggga ggtgcggggc ctgtgggtgg acagggtcct    600

agaggaatgg ggcctggaac tccagcagga tatggtagag ggagagaaga gtacgaaggc    660

ccaaacaaaa aaccccgatt ttagatgtga tatttaggct ttcattccag tttgttttgt    720

ttttttgttt agataccaat cttttaaatt cttgcatttt agtaagaaag ctatcttttt    780

atggatgtta gcagtttatt gacctaatat ttgtaaatgg tctgtttggg caggtaaaat    840

tatgtaatgc agtgtttgga acaggagaat ttttttttcc tttttatttc tttatttttt    900

cttttttact gtataatgtc cctcaagttt atggcagtgt accttgtgcc actgaatttc    960

caaagtgtac caattttttt ttttttactg tgcttcaaat aaatagaaaa atagttataa   1020

tattgatctt c                                                        1031


<210>  5829
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  5829

Met Gln Cys Leu Glu Gln Glu Asn Phe Phe Phe Leu Phe Ile Ser Leu 
1               5                   10                  15      


Phe Phe Leu Phe Tyr Cys Ile Met Ser Leu Lys Phe Met Ala Val Tyr 
            20                  25                  30          


Leu Val Pro Leu Asn Phe Gln Ser Val Pro Ile Phe Phe Phe Leu Leu 
        35                  40                  45              


Cys Phe Lys 
    50      


<210>  5830
<211>  2570
<212>  DNA
<213>  Homosapiens

<400>  5830
gccgcctgtg tcatccgcca ttttgtgaga agcaaggtgg cctccacgtt tcctgagcgt     60

cttcttcgct tttgcctcga ccgccccttg accacagaca tgtctcggga tcggttccgg    120

agtcgtggcg gtggcggtgg tggcttccac aggcgtggag gaggcggcgg ccgcggcggc    180

ctccacgact tccgttctcc gccgcccggc atgggcctca atcagaatcg cggccccatg    240

ggtcctggcc cgggccagag cggccctaag cctccgatcc cgccaccgcc tccacaccaa    300

cagcagcaac agccaccacc gcagcagcca ccgccgcagc agccgccacc gcatcagccg    360

ccgccgcatc cacagccgca tcagcagcag cagccgccgc caccgccgca ggactcttcc    420

aagcccgtcg ttgctcaggg acccggcccc gctcccggag taggcagcgc accaccagcc    480

tccagctcgg ccccgcccgc cactccacca acctcggggg ccccgccagg gtccgggcca    540

ggcccgactc cgaccccgcc gcctgcagtc acctcggccc ctcccggggc gccgccaccc    600

accccgccaa gcagcggggt ccctaccaca cctcctcagg ccggaggccc gccgcctccg    660

cccgcggcag tcccgggccc gggtccaggg cctaagcagg gcccaggtcc gggtggtccc    720

aaaggcggca aaatgcctgg cgggccgaag ccaggtggcg gcccgggcct aagtacgcct    780

ggcggccacc ccaagccgcc gcatcgaggc ggcggggagc cccgcggggg ccgccagcac    840

cacccgccct accaccagca gcatcaccag gggcccccgc ccggcgggcc cggcggccgc    900

agcgaggaga agatctcgga ctcggagggg tttaaagcca atttgtctct cttgaggagg    960

cctggagaga aaacttacac acagcgatgt cggttgtttg ttgggaatct acctgctgat   1020

atcacggagg atgaattcaa aagactattt gctaaatatg gagaaccagg agaagttttt   1080

atcaacaaag gcaaaggatt cggatttatt aagcttgaat ctagagcttt ggctgaaatt   1140

gccaaagccg aactggatga tacacccatg agaggtagac agcttcgagt tcgctttgcc   1200

acacatgctg ctgccctttc tgttcgtaat ctttcacctt atgtttccaa tgaactgttg   1260

gaagaagcct ttagccaatt tggtcctatt gaaagggctg ttgtaatagt ggatgatcgt   1320

ggaagatcta cagggaaagg cattgttgaa tttgcttcta agccagcagc aagaaaggca   1380

tttgaacgat gcagtgaagg tgttttctta ctgacgacaa ctcctcgtcc agtcattgtg   1440

gaaccacttg aacaactaga tgatgaagat ggtcttcctg aaaaacttgc ccagaagaat   1500

ccaatgtatc aaaaggagag agaaacccct cctcgttttg cccagcatgg cacgtttgag   1560

tacgaatatt ctcagcgatg gaagtctttg gatgaaatgg aaaaacagca aagggaacaa   1620

gttgaaaaaa acatgaaaga tgcaaaagac aaattggaaa gtgaaatgga agatgcctat   1680

catgaacatc aggcaaatct tttgcgccaa gatctgatga gacgacagga agaattaaga   1740

cgcatggaag aacttcacaa tcaagaaatg cagaaacgta aagaaatgca attgaggcaa   1800

gaggaggaac gacgtagaag agaggaagag atgatgattc gtcaacgtga gatggaagaa   1860

caaatgaggc gccaaagaga ggaaagttac agccgaatgg gctacatgga tccacgggaa   1920

agagacatgc gaatgggtgg cggaggagca atgaacatgg gagatcccta tggttcagga   1980

ggccagaaat ttccacctct aggaggtggt ggtggcatag gttatgaagc taatcctggc   2040

gttccaccag caaccatgag tggttccatg atgggaagtg acatgcgtac tgagcgcttt   2100

gggcagggag gtgcggggcc tgtgggtgga cagggtccta gaggaatggg gcctggaact   2160

ccagcaggat atggtagagg gagagaagag tacgaaggcc caaacaaaaa accccgattt   2220

tagatgtgat atttaggctt tcattccagt ttgttttgtt tttttgttta gataccaatc   2280

ttttaaattc ttgcatttta gtaagaaagc tatcttttta tggatgttag cagtttattg   2340

acctaatatt tgtaaatggt ctgtttgggc aggtaaaatt atgtaatgca gtgtttggaa   2400

caggagaatt tttttttcct ttttatttct ttattttttc ttttttactg tataatgtcc   2460

ctcaagttta tggcagtgta ccttgtgcca ctgaatttcc aaagtgtacc aatttttttt   2520

tttttactgt gcttcaaata aatagaaaaa tagttataat attgatcttc              2570


<210>  5831
<211>  707
<212>  PRT
<213>  Homosapiens

<400>  5831

Met Ser Arg Asp Arg Phe Arg Ser Arg Gly Gly Gly Gly Gly Gly Phe 
1               5                   10                  15      


His Arg Arg Gly Gly Gly Gly Gly Arg Gly Gly Leu His Asp Phe Arg 
            20                  25                  30          


Ser Pro Pro Pro Gly Met Gly Leu Asn Gln Asn Arg Gly Pro Met Gly 
        35                  40                  45              


Pro Gly Pro Gly Gln Ser Gly Pro Lys Pro Pro Ile Pro Pro Pro Pro 
    50                  55                  60                  


Pro His Gln Gln Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Gln 
65                  70                  75                  80  


Gln Pro Pro Pro His Gln Pro Pro Pro His Pro Gln Pro His Gln Gln 
                85                  90                  95      


Gln Gln Pro Pro Pro Pro Pro Gln Asp Ser Ser Lys Pro Val Val Ala 
            100                 105                 110         


Gln Gly Pro Gly Pro Ala Pro Gly Val Gly Ser Ala Pro Pro Ala Ser 
        115                 120                 125             


Ser Ser Ala Pro Pro Ala Thr Pro Pro Thr Ser Gly Ala Pro Pro Gly 
    130                 135                 140                 


Ser Gly Pro Gly Pro Thr Pro Thr Pro Pro Pro Ala Val Thr Ser Ala 
145                 150                 155                 160 


Pro Pro Gly Ala Pro Pro Pro Thr Pro Pro Ser Ser Gly Val Pro Thr 
                165                 170                 175     


Thr Pro Pro Gln Ala Gly Gly Pro Pro Pro Pro Pro Ala Ala Val Pro 
            180                 185                 190         


Gly Pro Gly Pro Gly Pro Lys Gln Gly Pro Gly Pro Gly Gly Pro Lys 
        195                 200                 205             


Gly Gly Lys Met Pro Gly Gly Pro Lys Pro Gly Gly Gly Pro Gly Leu 
    210                 215                 220                 


Ser Thr Pro Gly Gly His Pro Lys Pro Pro His Arg Gly Gly Gly Glu 
225                 230                 235                 240 


Pro Arg Gly Gly Arg Gln His His Pro Pro Tyr His Gln Gln His His 
                245                 250                 255     


Gln Gly Pro Pro Pro Gly Gly Pro Gly Gly Arg Ser Glu Glu Lys Ile 
            260                 265                 270         


Ser Asp Ser Glu Gly Phe Lys Ala Asn Leu Ser Leu Leu Arg Arg Pro 
        275                 280                 285             


Gly Glu Lys Thr Tyr Thr Gln Arg Cys Arg Leu Phe Val Gly Asn Leu 
    290                 295                 300                 


Pro Ala Asp Ile Thr Glu Asp Glu Phe Lys Arg Leu Phe Ala Lys Tyr 
305                 310                 315                 320 


Gly Glu Pro Gly Glu Val Phe Ile Asn Lys Gly Lys Gly Phe Gly Phe 
                325                 330                 335     


Ile Lys Leu Glu Ser Arg Ala Leu Ala Glu Ile Ala Lys Ala Glu Leu 
            340                 345                 350         


Asp Asp Thr Pro Met Arg Gly Arg Gln Leu Arg Val Arg Phe Ala Thr 
        355                 360                 365             


His Ala Ala Ala Leu Ser Val Arg Asn Leu Ser Pro Tyr Val Ser Asn 
    370                 375                 380                 


Glu Leu Leu Glu Glu Ala Phe Ser Gln Phe Gly Pro Ile Glu Arg Ala 
385                 390                 395                 400 


Val Val Ile Val Asp Asp Arg Gly Arg Ser Thr Gly Lys Gly Ile Val 
                405                 410                 415     


Glu Phe Ala Ser Lys Pro Ala Ala Arg Lys Ala Phe Glu Arg Cys Ser 
            420                 425                 430         


Glu Gly Val Phe Leu Leu Thr Thr Thr Pro Arg Pro Val Ile Val Glu 
        435                 440                 445             


Pro Leu Glu Gln Leu Asp Asp Glu Asp Gly Leu Pro Glu Lys Leu Ala 
    450                 455                 460                 


Gln Lys Asn Pro Met Tyr Gln Lys Glu Arg Glu Thr Pro Pro Arg Phe 
465                 470                 475                 480 


Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr Ser Gln Arg Trp Lys Ser 
                485                 490                 495     


Leu Asp Glu Met Glu Lys Gln Gln Arg Glu Gln Val Glu Lys Asn Met 
            500                 505                 510         


Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu Met Glu Asp Ala Tyr His 
        515                 520                 525             


Glu His Gln Ala Asn Leu Leu Arg Gln Asp Leu Met Arg Arg Gln Glu 
    530                 535                 540                 


Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Met Gln Lys Arg 
545                 550                 555                 560 


Lys Glu Met Gln Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu Glu 
                565                 570                 575     


Glu Met Met Ile Arg Gln Arg Glu Met Glu Glu Gln Met Arg Arg Gln 
            580                 585                 590         


Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr Met Asp Pro Arg Glu Arg 
        595                 600                 605             


Asp Met Arg Met Gly Gly Gly Gly Ala Met Asn Met Gly Asp Pro Tyr 
    610                 615                 620                 


Gly Ser Gly Gly Gln Lys Phe Pro Pro Leu Gly Gly Gly Gly Gly Ile 
625                 630                 635                 640 


Gly Tyr Glu Ala Asn Pro Gly Val Pro Pro Ala Thr Met Ser Gly Ser 
                645                 650                 655     


Met Met Gly Ser Asp Met Arg Thr Glu Arg Phe Gly Gln Gly Gly Ala 
            660                 665                 670         


Gly Pro Val Gly Gly Gln Gly Pro Arg Gly Met Gly Pro Gly Thr Pro 
        675                 680                 685             


Ala Gly Tyr Gly Arg Gly Arg Glu Glu Tyr Glu Gly Pro Asn Lys Lys 
    690                 695                 700                 


Pro Arg Phe 
705         


<210>  5832
<211>  453
<212>  DNA
<213>  Homosapiens

<400>  5832
tacgaatatt ctcagcgatg gaagtctttg gatgaaatgg aactccagca ggatatggta     60

gagggagaga agagtacgaa ggcccaaaca aaaaaccccg attttagatg tgatatttag    120

gctttcattc cagtttgttt tgtttttttg tttagatacc aatcttttaa attcttgcat    180

tttagtaaga aagctatctt tttatggatg ttagcagttt attgacctaa tatttgtaaa    240

tggtctgttt gggcaggtaa aattatgtaa tgcagtgttt ggaacaggag aatttttttt    300

tcctttttat ttctttattt tttctttttt actgtataat gtccctcaag tttatggcag    360

tgtaccttgt gccactgaat ttccaaagtg taccaatttt ttttttttta ctgtgcttca    420

aataaataga aaaatagtta taatattgat ctt                                 453


<210>  5833
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  5833

Met Gln Cys Leu Glu Gln Glu Asn Phe Phe Phe Leu Phe Ile Ser Leu 
1               5                   10                  15      


Phe Phe Leu Phe Tyr Cys Ile Met Ser Leu Lys Phe Met Ala Val Tyr 
            20                  25                  30          


Leu Val Pro Leu Asn Phe Gln Ser Val Pro Ile Phe Phe Phe Leu Leu 
        35                  40                  45              


Cys Phe Lys 
    50      


<210>  5834
<211>  1655
<212>  DNA
<213>  Homosapiens

<400>  5834
gccgcctgtg tcatccgcca ttttgtgaga agcaaggtgg cctccacgtt tcctgagcgt     60

cttcttcgct tttgcctcga ccgccccttg accacagaca tgtctcggga tcggttccgg    120

agtcgtggcg gtggcggtgg tggcttccac aggcgtggag gaggcggcgg ccgcggcggc    180

ctccacgact tccgttctcc gccgcccggc atgggcctca atcagaatcg cggccccatg    240

ggtcctggcc cgggccagag cggccctaag cctccgatcc cgccaccgcc tccacaccaa    300

cagcagcaac agccaccacc gcagcagcca ccgccgcagc agccgccacc gcatcagccg    360

ccgccgcatc cacagccgca tcagcagcag cagccgccgc caccgccgca ggactcttcc    420

aagcccgtcg ttgctcaggg acccggcccc gctcccggag taggcagcgc accaccagcc    480

tccagctcgg ccccgcccgc cactccacca acctcggggg ccccgccagg gtccgggcca    540

ggcccgactc cgaccccgcc gcctgcagtc acctcggccc ctcccggggc gccgccaccc    600

accccgccaa gcagcggggt ccctaccaca cctcctcagg ccggaggccc gccgcctccg    660

cccgcggcag tcccgggccc gggtccaggg cctaagcagg gcccaggtcc gggtggtccc    720

aaaggcggca aaatgcctgg cgggccgaag ccaggtggcg gcccgggcct aagtacgcct    780

ggcggccacc ccaagccgcc gcatcgaggc ggcggggagc cccgcggggg ccgccagcac    840

cacccgccct accaccagca gcatcaccag gggcccccgc ccggcgggcc cggcggccgc    900

agcgaggaga agatctcgga ctcggagggg tttaaagcca atttgtctct cttgaggagg    960

cctggagaga aaacttacac acagcgatgt cggttgtttg ttgggaatct acctgctgat   1020

atcacggagg atgaattcaa aagactattt gctaaatatg gagaaccagg agaagttttt   1080

atcaacaaag gcaaaggatt cggatttatt aagcttgaat ctagagcttt ggctgaaatt   1140

gccaaagccg aactggatga tacacccatg agaggtagac agcttcgagt tcgctttgcc   1200

acacatgctg ctgccctttc tgttcgtaat ctttcacctt atgtttccaa tgaactgttg   1260

gaagaagcct ttagccaatt tggtcctatt gaaagggctg ttgtaatagt ggatgatcgt   1320

ggaagatcta cagggaaagg cattgttgaa tttgcttcta agccagcagc aagaaaggca   1380

tttgaacgat gcagtgaagg tgttttctta ctgacgacaa ctcctcgtcc agtcattgtg   1440

gaaccacttg aacaactaga tgatgaagat ggtcttcctg aaaaacttgc ccagaagaat   1500

ccaatgtatc aaaaggagag agaaacccct cctcgttttg cccagcatgg cacgtttgag   1560

tacgaatatt ctcagcgatg gaagtctttg gatgaaatgg aaaaacagca aagggaacaa   1620

gttgaaaaaa acatgaaaga tgcaaaagac aaatt                              1655


<210>  5835
<211>  517
<212>  PRT
<213>  Homosapiens

<400>  5835

Met Ser Arg Asp Arg Phe Arg Ser Arg Gly Gly Gly Gly Gly Gly Phe 
1               5                   10                  15      


His Arg Arg Gly Gly Gly Gly Gly Arg Gly Gly Leu His Asp Phe Arg 
            20                  25                  30          


Ser Pro Pro Pro Gly Met Gly Leu Asn Gln Asn Arg Gly Pro Met Gly 
        35                  40                  45              


Pro Gly Pro Gly Gln Ser Gly Pro Lys Pro Pro Ile Pro Pro Pro Pro 
    50                  55                  60                  


Pro His Gln Gln Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Gln 
65                  70                  75                  80  


Gln Pro Pro Pro His Gln Pro Pro Pro His Pro Gln Pro His Gln Gln 
                85                  90                  95      


Gln Gln Pro Pro Pro Pro Pro Gln Asp Ser Ser Lys Pro Val Val Ala 
            100                 105                 110         


Gln Gly Pro Gly Pro Ala Pro Gly Val Gly Ser Ala Pro Pro Ala Ser 
        115                 120                 125             


Ser Ser Ala Pro Pro Ala Thr Pro Pro Thr Ser Gly Ala Pro Pro Gly 
    130                 135                 140                 


Ser Gly Pro Gly Pro Thr Pro Thr Pro Pro Pro Ala Val Thr Ser Ala 
145                 150                 155                 160 


Pro Pro Gly Ala Pro Pro Pro Thr Pro Pro Ser Ser Gly Val Pro Thr 
                165                 170                 175     


Thr Pro Pro Gln Ala Gly Gly Pro Pro Pro Pro Pro Ala Ala Val Pro 
            180                 185                 190         


Gly Pro Gly Pro Gly Pro Lys Gln Gly Pro Gly Pro Gly Gly Pro Lys 
        195                 200                 205             


Gly Gly Lys Met Pro Gly Gly Pro Lys Pro Gly Gly Gly Pro Gly Leu 
    210                 215                 220                 


Ser Thr Pro Gly Gly His Pro Lys Pro Pro His Arg Gly Gly Gly Glu 
225                 230                 235                 240 


Pro Arg Gly Gly Arg Gln His His Pro Pro Tyr His Gln Gln His His 
                245                 250                 255     


Gln Gly Pro Pro Pro Gly Gly Pro Gly Gly Arg Ser Glu Glu Lys Ile 
            260                 265                 270         


Ser Asp Ser Glu Gly Phe Lys Ala Asn Leu Ser Leu Leu Arg Arg Pro 
        275                 280                 285             


Gly Glu Lys Thr Tyr Thr Gln Arg Cys Arg Leu Phe Val Gly Asn Leu 
    290                 295                 300                 


Pro Ala Asp Ile Thr Glu Asp Glu Phe Lys Arg Leu Phe Ala Lys Tyr 
305                 310                 315                 320 


Gly Glu Pro Gly Glu Val Phe Ile Asn Lys Gly Lys Gly Phe Gly Phe 
                325                 330                 335     


Ile Lys Leu Glu Ser Arg Ala Leu Ala Glu Ile Ala Lys Ala Glu Leu 
            340                 345                 350         


Asp Asp Thr Pro Met Arg Gly Arg Gln Leu Arg Val Arg Phe Ala Thr 
        355                 360                 365             


His Ala Ala Ala Leu Ser Val Arg Asn Leu Ser Pro Tyr Val Ser Asn 
    370                 375                 380                 


Glu Leu Leu Glu Glu Ala Phe Ser Gln Phe Gly Pro Ile Glu Arg Ala 
385                 390                 395                 400 


Val Val Ile Val Asp Asp Arg Gly Arg Ser Thr Gly Lys Gly Ile Val 
                405                 410                 415     


Glu Phe Ala Ser Lys Pro Ala Ala Arg Lys Ala Phe Glu Arg Cys Ser 
            420                 425                 430         


Glu Gly Val Phe Leu Leu Thr Thr Thr Pro Arg Pro Val Ile Val Glu 
        435                 440                 445             


Pro Leu Glu Gln Leu Asp Asp Glu Asp Gly Leu Pro Glu Lys Leu Ala 
    450                 455                 460                 


Gln Lys Asn Pro Met Tyr Gln Lys Glu Arg Glu Thr Pro Pro Arg Phe 
465                 470                 475                 480 


Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr Ser Gln Arg Trp Lys Ser 
                485                 490                 495     


Leu Asp Glu Met Glu Lys Gln Gln Arg Glu Gln Val Glu Lys Asn Met 
            500                 505                 510         


Lys Asp Ala Lys Asp 
        515         


<210>  5836
<211>  1285
<212>  DNA
<213>  Homosapiens

<400>  5836
agacaaggca aatttaagta ggctcatggc ttttccagtt gggttggaaa gttcctctcc     60

gatgactgtt atattctcaa agaaatatga ggagaggggc agggcatggt ggctcacatc    120

cgtaatccta gcaaaatcat agtggcctac agccaacgcc ttcttcgctc actggccaac    180

tggaaacttc agtcccccca tgcctcccgc ctctcaccca ggggccaata ggaatgatca    240

gaggttcgca acttagtgtc atcaagcata gtaattgcaa ttggctattg gagctgtcga    300

tcgtggagta ggcggggccg tgccagctgg cctatataag acgaggacaa aggcggcgcg    360

ccgcctgtgt catccgccat tttgtgagaa gcaaggtggc ctccacgttt cctgagcgtc    420

ttcttcgctt ttgcctcgac cgccccttga ccacagacat gtctcgggat cggttccgga    480

gtcgtggcgg tggcggtggt ggcttccaca ggcgtggagg aggcggcggc cgcggcggcc    540

tccacgactt ccgttctccg ccgcccggca tgggcctcaa tcagaatcgc ggccccatgg    600

gtcctggccc gggccagagc ggccctaagc ctccgatccc gccaccgcct ccacaccaac    660

agcagcaaca gccaccaccg cagcagccac cgccgcagca gccgccaccg catcagccgc    720

cgccgcatcc acagccgcat cagcagcagc agccgccgcc accgccgcag gactcttcca    780

agcccgtcgt tgctcaggga cccggccccg ctcccggagt aggcagcgca ccaccagcct    840

ccagctcggc cccgcccgcc actccaccaa cctcgggggc cccgccaggg tccgggccag    900

gcccgactcc gaccccgccg cctgcagtca cctcggcccc tcccggggcg ccgccaccca    960

ccccgccaag cagcggggtc cctaccacac ctcctcaggc cggaggcccg ccgcctccgc   1020

ccgcggcagt cccgggcccg ggtccagggc ctaagcaggg cccaggtccg ggtggtccca   1080

aaggcggcaa aatgcctggc gggccgaagc caggtggcgg cccgggccta agtacgcctg   1140

gcggccaccc caagccgccg catcgaggcg gcggggagcc ccgcgggggc cgccagcacc   1200

acccgcccta ccaccagcag catcaccagg ggcccccgcc cggcgggccc ggcggccgca   1260

gcgaggagaa gatctcggac tcgga                                         1285


<210>  5837
<211>  41
<212>  PRT
<213>  Homosapiens

<400>  5837

Met Val Ala His Ile Arg Asn Pro Ser Lys Ile Ile Val Ala Tyr Ser 
1               5                   10                  15      


Gln Arg Leu Leu Arg Ser Leu Ala Asn Trp Lys Leu Gln Ser Pro His 
            20                  25                  30          


Ala Ser Arg Leu Ser Pro Arg Gly Gln 
        35                  40      


<210>  5838
<211>  6993
<212>  DNA
<213>  Homosapiens

<400>  5838
agtgtgggcg ggggccgggg ggccgagagg taccgccgcc accgcgcggg gagccgcagc     60

ggttccgagc ggggcccaac atggcggaga gagaggtgga gtccggcccc cgaaagaggt    120

ttgaacaaaa aagtggtgca gtttttgatg aaattgtaga gaactgtggt ggtatcatgg    180

atacagaaat gtctgaagat atagaccaca acttaactcc tacccttgac agcatgtctt    240

atggaatgcc gaatcaaaca ggatctgaaa attcattgct ggatgaagat gattattttt    300

tgaactctgg ggatcttgca ggaattccag tcgttggtag tgacaatgag gatgaacagg    360

attttagttc aaaggacaat cttgtttctt caattcatac tgatgatagc ttggaagtag    420

agagaagagt cacacagcat gaatcagaca atgaaaatga aatacaaatt caaaataagt    480

taaaaaaaga ctttcctaaa caatttgatc aggtttctgt ctttaaatca atacggaaag    540

attttagtct agtaagagaa aacagcaaag agacattttc tggaaaggag aaaaatagag    600

acctaactta tgaacgtgaa aaacggttgg ataaacccca taaagatttg gattcaaggt    660

tgaaaagcag tttttttgat aaagcagcta atcaagttga agaaacatta catacccatt    720

taccacaaac cccagaaaca aactttaggg attccagcta cccatttgcc aataaagaat    780

ccattggttc ggaactgggg aattcctttg catcaaatat tagaattaaa gaagaacctt    840

tggatgatga gtatgacaaa gcaatggcac cacagcaggg actactagac aaaataaaag    900

atgaacctga caatgctcaa gagtatagtc atggccaaca gcaaaaaact caagaggggg    960

aactgaaaat tagtgctgtg ttttcagtca gtggcagccc tcttgctcca cagttgacta   1020

ctggctttca gccctcactg gcgtcatctg gcatgaataa aatgcttcct tcagttccag   1080

ccacagctgt tcgagtttcc tgttctggtt gtaaaaaaat cctccagaag gggcaaactg   1140

cttatcagag gaaagggtct actcagctat tctgctccac actgtgcctc actggatata   1200

cagttccacc tgcccgccca ccgcctcctc tcaccaagaa aacttgttca agttgctcaa   1260

aagacatttt aaatccaaag gatgtgatca gtgcccagtt tgaaaacacc accactagta   1320

aagatttttg cagtcagtca tgtttgtcaa catatgaact gaaaaaaaaa cctattgtta   1380

ccataaatac aaatagtatt tcaaccaaat gcagcatgtg tcagaagaat gctgttattc   1440

gacatgaagt taattaccag aatgtggtcc ataaactttg cagtgatgcc tgcttctcta   1500

agtttcgttc tgctaacaac ctcaccatga actgttgtga gaactgtggg ggttactgtt   1560

acagtgggtc gggacaatgc cacatgcttc agatagaggg acagtctaag aagttttgta   1620

gttcatcgtg tatcacggca tacaagcaga aatcagccaa aattacaccg tgtgcgcttt   1680

gcaaatcatt gagatcctca gcagaaatga ttgaaaatac caatagcttg gggaagacag   1740

agcttttctg ttctgttaat tgcttatctg cttacagagt taaaatggtt acttctgcag   1800

gtgtacaagt tcagtgtaac agttgtaaaa cctcagcaat tcctcagtat cacctagcca   1860

tgtcagatgg aagtatacgc aacttctgca gctacagctg tgtggtagct ttccagaatt   1920

tattcaacaa accaactgga atgaattctt cagtagtgcc cttgtctcag ggccaagtaa   1980

ttgtaagcat ccccacaggt tccacagtgt cagccggagg aggtagcaca tctgctgttt   2040

ctcccacctc catcagtagc tctgctgcag ctggtctcca gcgtctcgct gcccagtccc   2100

agcatgttgg gtttgcacga agtgttgtga aactcaaatg tcaacactgt aaccgtcttt   2160

ttgccacaaa accagaactt cttgactata agggcaaaat gtttcagttc tgtggcaaga   2220

attgttctga tgaatataag aaaataaata atgtaatggc aatgtgtgaa tattgtaaaa   2280

ttgagaaaat tgtaaaggag actgttcggt tctcaggtgc tgacaagtca ttctgtagtg   2340

aaggttgcaa attgctttat aaacatgact tggcaaaacg ctggggaaat cactgtaaaa   2400

tgtgcagtta ttgtttacag acatctccca aattggtaca gaataattta ggagggaaag   2460

tggaagagtt ctgttgtgaa gaatgcatgt ccaaatatac agttttgttc tatcagatgg   2520

ccaaatgtga tgcttgtaag cgacagggta aactcagtga gtccttgaaa tggcgagggg   2580

aaatgaaaca tttctgtaac ctgctttgta tcttgatgtt ctgtaatcag caaagtgtat   2640

gtgacccgcc ttcacaaaat aatgcagcaa atatttccat ggttcaagct gcttcagcag   2700

gacccccatc tctgagaaaa gattcgactc cagttatagc caatgtagta tcattggcaa   2760

gtgcccctgc tgctcagcct acagtgaatt ctaacagtgt cttacaaggt gcagttccaa   2820

cagtaacagc gaaaatcatc ggtgatgcaa gtactcaaac agatgccctg aaactgccac   2880

cttcccaacc tccaaggctt ttgaagaaca aagctttatt atgcaaaccc atcacacaga   2940

ctaaagccac ctcttgcaaa ccacataccc aaaacaaaga atgccagaca gaagacactc   3000

caagtcagcc ccagattatt gtggtgccag ttcccgtacc agtgtttgtt cccatacctc   3060

ttcaccttta tactcaatat gctccagtcc catttggaat tccagttcca atgcctgtcc   3120

ctatgcttat tccatcttca atggatagtg aagataaagt cacagagagt attgaagaca   3180

ttaaagaaaa gcttcccaca catccatttg aagctgatct ccttgagatg gcagaaatga   3240

ttgcagaaga tgaagagaag aagactctat ctcagggaga gtcccaaact tctgaacacg   3300

aactctttct agacaccaag atatttgaaa aagaccaagg aagtacatac agtggtgatc   3360

ttgaatcaga ggcagtatct actccacata gctgggagga agagctgaat cactatgcct   3420

taaagtcaaa tgctgtgcaa gaggctgatt cagaattgaa gcagttctca aaaggggaaa   3480

ctgaacagga cctggaagca gattttccat cagactcctt tgacccactt aataaaggac   3540

agggaatcca ggcacgttcc cgaacaagac gacgacacag agatggcttc ccccaaccca   3600

gacgaagagg acggaagaag tctatagtgg ctgtggagcc caggagtctt attcaaggag   3660

cctttcaagg ctgctcagtg tccgggatga cactgaaata catgtatggg gtaaatgctt   3720

ggaagaactg ggttcagtgg aaaaatgcca aggaagagca gggggatcta aaatgtggag   3780

gggttgaaca ggcctcatct agcccacgtt ctgacccctt aggaagtact caagaccatg   3840

cactctctca agaatcctca gagccaggct gtagagtccg ctctatcaag ctgaaggaag   3900

acattctgtc ctgcactttt gctgagttga gtttgggctt atgccagttt atccaagagg   3960

tgcggagacc aaatggtgaa aaatatgatc cagacagtat cttatacttg tgccttggaa   4020

ttcaacagta cctgtttgaa aatggtagaa tagataacat ttttactgag ccctattcca   4080

gatttatgat tgaacttacc aaactcttga aaatatggga acctacaata cttcctaatg   4140

gttacatgtt ctctcgcatt gaggaagagc atttgtggga gtgcaaacag ctgggcgctt   4200

actcaccaat cgtcctttta aacaccctcc ttttcttcaa taccaaatac ttccaactaa   4260

agaatgttac tgagcacttg aagctttcct ttgcccatgt gatgagacgg accaggactc   4320

tgaagtacag taccaagatg acatatctga ggttcttccc acctttacag aagcaggagt   4380

cagaaccaga taaactgact gttggcaaga ggaaacgaaa tgaagatgat gaggttccag   4440

tgggggtgga gatggcagag aatactgaca atccactaag atgcccagtc cgactttatg   4500

agttttacct gtcaaaatgt tctgaaagtg tgaagcaaag gaatgatgtg ttttaccttc   4560

aacctgagcg ctcctgtgtc ccgaatagcc ccatgtggta ctccacattc ccgatagacc   4620

ctggaaccct ggacaccatg ttaacacgta ttctcatggt gagggaggta catgaagaac   4680

ttgccaaagc caaatctgaa gactctgatg ttgaattatc agattaaaac ggaagtgagg   4740

ttcttatttt catacatatt ggtatgcacc aaactgtgaa tgcatccagc tgttggaaaa   4800

tgatgtataa gtctaagtcc tcttgacttg accataagat catggaaaac agatgacttg   4860

tgaaccccac agtgtggatg tgcaaatgaa aattgaagga aagaatatga actgagaaat   4920

gttctttggc agtgatatag ttcttagaca tcttcagaat gactaatttc tccgagtggt   4980

gcataatctt attttgtttg ggagtaacaa atcgtggaat atttttaagg aaaactgttg   5040

tataaaactt taccatagta accttagacc ttagagaggt agctttggag tgaaactttg   5100

gctgcaatag gctactttgg caagccctcc gtaaaagtca gaggagagat cagtacagag   5160

ctaagagtga catcaaatga ggactgtggg acccagattt gaagacccaa taaaaatact   5220

caacttttta aaaaagatag tgaagtggtc ttgattgatt ttgattttca ctgccaagcc   5280

aatcatgtga aggacagaag cttttgccat gggcccctca catcagggaa aatgaccttc   5340

actgctgtta acagtaatgt gtccctttca ttttctggat caagccttct cagcggtggg   5400

tctggatgtg ggtaaactaa ggtaaagggg atgatattcc acaaactaat tatgcacaca   5460

gaaaatctgt ggagcctatc agaccccaag tgtcttgaaa tgtttgtaga aacccactaa   5520

aatgcccctt ctctgggtgt gggcccttat tgcagctgtc tcacagcctg agctgtggta   5580

cagagaaatg ggggttctcc ttttattttc attttttttc cccaatggca gcttttctcc   5640

cgttgtttta ccttcctatt tcccaaacag ttcctcttat tttgtctttt gcaccagttt   5700

ctggaggccc ttgtcatttc aaaaaggata gtctcttttc ttactctggc aaacctgtga   5760

gtgattccac aaagatacag tattacttag ctatctgaat tatgatagaa aaggtcctag   5820

ttaggttcct atataaagca tttggaagat gaccttgttg cccttgaaac ttgaaaatag   5880

ggattctggg gtgaggatac aaagacattg tcttgcatat ccataagcag gtcttagagc   5940

attattccaa actctagctg tttcagtagt tctatgagga ttgcaagtca taggtgtgtg   6000

tggcatatca gtccatctcc ctcatctcca ttctcagttt cttccccaca aaatttggaa   6060

tcaaagcttt tatgacgttt gccaattgca gaacttcttc agctaaggtt aatttgacgc   6120

tatgataaaa ctgagagatg tcaaaaagcc tcttagaaat tttaatcttg aaagactttt   6180

cagggtatct cattttttag gtgggggtgg caggtgtatt tcttttttaa caaataaaag   6240

gcatttaagt aaaactaaaa tgaaaaaagt aggccttctg acattgtgta cttggtggtt   6300

ctgtccctct gcctgtaaca aatctcattt ttgttaccaa gaactgtatg aaagaagtaa   6360

atccaccccg attctgtatg attaattcca tctgtgtttg tcatttctga ctggaaaact   6420

tcttactcca taccttgttc gatatggagg acaaataatt ggattgtctg ataagtctgc   6480

caataaacta tccagaaata gcaagtgtaa tagtccccac tatacgaatt ttatggtttg   6540

tataaacact aacattttcc ccttctgtag ttgtatgaaa aaacaaatat tgttagcata   6600

gtagataaat tgttatgaaa taccagaaaa aaaaatctgt atcttttact gagaacaccc   6660

aatacccaga taaatgactg tatcaggatt tcatttgcat gttagtccac agagttgccc   6720

agaaccctaa atttattcat aagagaaaat attgattaat tattggtcat tcctcataag   6780

tgtagctgtt gatgtgtgcg tctgattatt gcttttttaa ttttatgaaa attgtgtaaa   6840

attacatttt ttttccaggg gagaaaaaaa catcaaacaa aaacatctaa atcatccttt   6900

ttgttctttt tcagttttta accactttta ggttttcccc ttacagaaac cacagaaata   6960

ttcccttaga ataaaatagt atatttgtat ttg                                6993


<210>  5839
<211>  1548
<212>  PRT
<213>  Homosapiens

<400>  5839

Met Ala Glu Arg Glu Val Glu Ser Gly Pro Arg Lys Arg Phe Glu Gln 
1               5                   10                  15      


Lys Ser Gly Ala Val Phe Asp Glu Ile Val Glu Asn Cys Gly Gly Ile 
            20                  25                  30          


Met Asp Thr Glu Met Ser Glu Asp Ile Asp His Asn Leu Thr Pro Thr 
        35                  40                  45              


Leu Asp Ser Met Ser Tyr Gly Met Pro Asn Gln Thr Gly Ser Glu Asn 
    50                  55                  60                  


Ser Leu Leu Asp Glu Asp Asp Tyr Phe Leu Asn Ser Gly Asp Leu Ala 
65                  70                  75                  80  


Gly Ile Pro Val Val Gly Ser Asp Asn Glu Asp Glu Gln Asp Phe Ser 
                85                  90                  95      


Ser Lys Asp Asn Leu Val Ser Ser Ile His Thr Asp Asp Ser Leu Glu 
            100                 105                 110         


Val Glu Arg Arg Val Thr Gln His Glu Ser Asp Asn Glu Asn Glu Ile 
        115                 120                 125             


Gln Ile Gln Asn Lys Leu Lys Lys Asp Phe Pro Lys Gln Phe Asp Gln 
    130                 135                 140                 


Val Ser Val Phe Lys Ser Ile Arg Lys Asp Phe Ser Leu Val Arg Glu 
145                 150                 155                 160 


Asn Ser Lys Glu Thr Phe Ser Gly Lys Glu Lys Asn Arg Asp Leu Thr 
                165                 170                 175     


Tyr Glu Arg Glu Lys Arg Leu Asp Lys Pro His Lys Asp Leu Asp Ser 
            180                 185                 190         


Arg Leu Lys Ser Ser Phe Phe Asp Lys Ala Ala Asn Gln Val Glu Glu 
        195                 200                 205             


Thr Leu His Thr His Leu Pro Gln Thr Pro Glu Thr Asn Phe Arg Asp 
    210                 215                 220                 


Ser Ser Tyr Pro Phe Ala Asn Lys Glu Ser Ile Gly Ser Glu Leu Gly 
225                 230                 235                 240 


Asn Ser Phe Ala Ser Asn Ile Arg Ile Lys Glu Glu Pro Leu Asp Asp 
                245                 250                 255     


Glu Tyr Asp Lys Ala Met Ala Pro Gln Gln Gly Leu Leu Asp Lys Ile 
            260                 265                 270         


Lys Asp Glu Pro Asp Asn Ala Gln Glu Tyr Ser His Gly Gln Gln Gln 
        275                 280                 285             


Lys Thr Gln Glu Gly Glu Leu Lys Ile Ser Ala Val Phe Ser Val Ser 
    290                 295                 300                 


Gly Ser Pro Leu Ala Pro Gln Leu Thr Thr Gly Phe Gln Pro Ser Leu 
305                 310                 315                 320 


Ala Ser Ser Gly Met Asn Lys Met Leu Pro Ser Val Pro Ala Thr Ala 
                325                 330                 335     


Val Arg Val Ser Cys Ser Gly Cys Lys Lys Ile Leu Gln Lys Gly Gln 
            340                 345                 350         


Thr Ala Tyr Gln Arg Lys Gly Ser Thr Gln Leu Phe Cys Ser Thr Leu 
        355                 360                 365             


Cys Leu Thr Gly Tyr Thr Val Pro Pro Ala Arg Pro Pro Pro Pro Leu 
    370                 375                 380                 


Thr Lys Lys Thr Cys Ser Ser Cys Ser Lys Asp Ile Leu Asn Pro Lys 
385                 390                 395                 400 


Asp Val Ile Ser Ala Gln Phe Glu Asn Thr Thr Thr Ser Lys Asp Phe 
                405                 410                 415     


Cys Ser Gln Ser Cys Leu Ser Thr Tyr Glu Leu Lys Lys Lys Pro Ile 
            420                 425                 430         


Val Thr Ile Asn Thr Asn Ser Ile Ser Thr Lys Cys Ser Met Cys Gln 
        435                 440                 445             


Lys Asn Ala Val Ile Arg His Glu Val Asn Tyr Gln Asn Val Val His 
    450                 455                 460                 


Lys Leu Cys Ser Asp Ala Cys Phe Ser Lys Phe Arg Ser Ala Asn Asn 
465                 470                 475                 480 


Leu Thr Met Asn Cys Cys Glu Asn Cys Gly Gly Tyr Cys Tyr Ser Gly 
                485                 490                 495     


Ser Gly Gln Cys His Met Leu Gln Ile Glu Gly Gln Ser Lys Lys Phe 
            500                 505                 510         


Cys Ser Ser Ser Cys Ile Thr Ala Tyr Lys Gln Lys Ser Ala Lys Ile 
        515                 520                 525             


Thr Pro Cys Ala Leu Cys Lys Ser Leu Arg Ser Ser Ala Glu Met Ile 
    530                 535                 540                 


Glu Asn Thr Asn Ser Leu Gly Lys Thr Glu Leu Phe Cys Ser Val Asn 
545                 550                 555                 560 


Cys Leu Ser Ala Tyr Arg Val Lys Met Val Thr Ser Ala Gly Val Gln 
                565                 570                 575     


Val Gln Cys Asn Ser Cys Lys Thr Ser Ala Ile Pro Gln Tyr His Leu 
            580                 585                 590         


Ala Met Ser Asp Gly Ser Ile Arg Asn Phe Cys Ser Tyr Ser Cys Val 
        595                 600                 605             


Val Ala Phe Gln Asn Leu Phe Asn Lys Pro Thr Gly Met Asn Ser Ser 
    610                 615                 620                 


Val Val Pro Leu Ser Gln Gly Gln Val Ile Val Ser Ile Pro Thr Gly 
625                 630                 635                 640 


Ser Thr Val Ser Ala Gly Gly Gly Ser Thr Ser Ala Val Ser Pro Thr 
                645                 650                 655     


Ser Ile Ser Ser Ser Ala Ala Ala Gly Leu Gln Arg Leu Ala Ala Gln 
            660                 665                 670         


Ser Gln His Val Gly Phe Ala Arg Ser Val Val Lys Leu Lys Cys Gln 
        675                 680                 685             


His Cys Asn Arg Leu Phe Ala Thr Lys Pro Glu Leu Leu Asp Tyr Lys 
    690                 695                 700                 


Gly Lys Met Phe Gln Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys 
705                 710                 715                 720 


Lys Ile Asn Asn Val Met Ala Met Cys Glu Tyr Cys Lys Ile Glu Lys 
                725                 730                 735     


Ile Val Lys Glu Thr Val Arg Phe Ser Gly Ala Asp Lys Ser Phe Cys 
            740                 745                 750         


Ser Glu Gly Cys Lys Leu Leu Tyr Lys His Asp Leu Ala Lys Arg Trp 
        755                 760                 765             


Gly Asn His Cys Lys Met Cys Ser Tyr Cys Leu Gln Thr Ser Pro Lys 
    770                 775                 780                 


Leu Val Gln Asn Asn Leu Gly Gly Lys Val Glu Glu Phe Cys Cys Glu 
785                 790                 795                 800 


Glu Cys Met Ser Lys Tyr Thr Val Leu Phe Tyr Gln Met Ala Lys Cys 
                805                 810                 815     


Asp Ala Cys Lys Arg Gln Gly Lys Leu Ser Glu Ser Leu Lys Trp Arg 
            820                 825                 830         


Gly Glu Met Lys His Phe Cys Asn Leu Leu Cys Ile Leu Met Phe Cys 
        835                 840                 845             


Asn Gln Gln Ser Val Cys Asp Pro Pro Ser Gln Asn Asn Ala Ala Asn 
    850                 855                 860                 


Ile Ser Met Val Gln Ala Ala Ser Ala Gly Pro Pro Ser Leu Arg Lys 
865                 870                 875                 880 


Asp Ser Thr Pro Val Ile Ala Asn Val Val Ser Leu Ala Ser Ala Pro 
                885                 890                 895     


Ala Ala Gln Pro Thr Val Asn Ser Asn Ser Val Leu Gln Gly Ala Val 
            900                 905                 910         


Pro Thr Val Thr Ala Lys Ile Ile Gly Asp Ala Ser Thr Gln Thr Asp 
        915                 920                 925             


Ala Leu Lys Leu Pro Pro Ser Gln Pro Pro Arg Leu Leu Lys Asn Lys 
    930                 935                 940                 


Ala Leu Leu Cys Lys Pro Ile Thr Gln Thr Lys Ala Thr Ser Cys Lys 
945                 950                 955                 960 


Pro His Thr Gln Asn Lys Glu Cys Gln Thr Glu Asp Thr Pro Ser Gln 
                965                 970                 975     


Pro Gln Ile Ile Val Val Pro Val Pro Val Pro Val Phe Val Pro Ile 
            980                 985                 990         


Pro Leu His Leu Tyr Thr Gln Tyr  Ala Pro Val Pro Phe  Gly Ile Pro 
        995                 1000                 1005             


Val Pro  Met Pro Val Pro Met  Leu Ile Pro Ser Ser  Met Asp Ser 
    1010                 1015                 1020             


Glu Asp  Lys Val Thr Glu Ser  Ile Glu Asp Ile Lys  Glu Lys Leu 
    1025                 1030                 1035             


Pro Thr  His Pro Phe Glu Ala  Asp Leu Leu Glu Met  Ala Glu Met 
    1040                 1045                 1050             


Ile Ala  Glu Asp Glu Glu Lys  Lys Thr Leu Ser Gln  Gly Glu Ser 
    1055                 1060                 1065             


Gln Thr  Ser Glu His Glu Leu  Phe Leu Asp Thr Lys  Ile Phe Glu 
    1070                 1075                 1080             


Lys Asp  Gln Gly Ser Thr Tyr  Ser Gly Asp Leu Glu  Ser Glu Ala 
    1085                 1090                 1095             


Val Ser  Thr Pro His Ser Trp  Glu Glu Glu Leu Asn  His Tyr Ala 
    1100                 1105                 1110             


Leu Lys  Ser Asn Ala Val Gln  Glu Ala Asp Ser Glu  Leu Lys Gln 
    1115                 1120                 1125             


Phe Ser  Lys Gly Glu Thr Glu  Gln Asp Leu Glu Ala  Asp Phe Pro 
    1130                 1135                 1140             


Ser Asp  Ser Phe Asp Pro Leu  Asn Lys Gly Gln Gly  Ile Gln Ala 
    1145                 1150                 1155             


Arg Ser  Arg Thr Arg Arg Arg  His Arg Asp Gly Phe  Pro Gln Pro 
    1160                 1165                 1170             


Arg Arg  Arg Gly Arg Lys Lys  Ser Ile Val Ala Val  Glu Pro Arg 
    1175                 1180                 1185             


Ser Leu  Ile Gln Gly Ala Phe  Gln Gly Cys Ser Val  Ser Gly Met 
    1190                 1195                 1200             


Thr Leu  Lys Tyr Met Tyr Gly  Val Asn Ala Trp Lys  Asn Trp Val 
    1205                 1210                 1215             


Gln Trp  Lys Asn Ala Lys Glu  Glu Gln Gly Asp Leu  Lys Cys Gly 
    1220                 1225                 1230             


Gly Val  Glu Gln Ala Ser Ser  Ser Pro Arg Ser Asp  Pro Leu Gly 
    1235                 1240                 1245             


Ser Thr  Gln Asp His Ala Leu  Ser Gln Glu Ser Ser  Glu Pro Gly 
    1250                 1255                 1260             


Cys Arg  Val Arg Ser Ile Lys  Leu Lys Glu Asp Ile  Leu Ser Cys 
    1265                 1270                 1275             


Thr Phe  Ala Glu Leu Ser Leu  Gly Leu Cys Gln Phe  Ile Gln Glu 
    1280                 1285                 1290             


Val Arg  Arg Pro Asn Gly Glu  Lys Tyr Asp Pro Asp  Ser Ile Leu 
    1295                 1300                 1305             


Tyr Leu  Cys Leu Gly Ile Gln  Gln Tyr Leu Phe Glu  Asn Gly Arg 
    1310                 1315                 1320             


Ile Asp  Asn Ile Phe Thr Glu  Pro Tyr Ser Arg Phe  Met Ile Glu 
    1325                 1330                 1335             


Leu Thr  Lys Leu Leu Lys Ile  Trp Glu Pro Thr Ile  Leu Pro Asn 
    1340                 1345                 1350             


Gly Tyr  Met Phe Ser Arg Ile  Glu Glu Glu His Leu  Trp Glu Cys 
    1355                 1360                 1365             


Lys Gln  Leu Gly Ala Tyr Ser  Pro Ile Val Leu Leu  Asn Thr Leu 
    1370                 1375                 1380             


Leu Phe  Phe Asn Thr Lys Tyr  Phe Gln Leu Lys Asn  Val Thr Glu 
    1385                 1390                 1395             


His Leu  Lys Leu Ser Phe Ala  His Val Met Arg Arg  Thr Arg Thr 
    1400                 1405                 1410             


Leu Lys  Tyr Ser Thr Lys Met  Thr Tyr Leu Arg Phe  Phe Pro Pro 
    1415                 1420                 1425             


Leu Gln  Lys Gln Glu Ser Glu  Pro Asp Lys Leu Thr  Val Gly Lys 
    1430                 1435                 1440             


Arg Lys  Arg Asn Glu Asp Asp  Glu Val Pro Val Gly  Val Glu Met 
    1445                 1450                 1455             


Ala Glu  Asn Thr Asp Asn Pro  Leu Arg Cys Pro Val  Arg Leu Tyr 
    1460                 1465                 1470             


Glu Phe  Tyr Leu Ser Lys Cys  Ser Glu Ser Val Lys  Gln Arg Asn 
    1475                 1480                 1485             


Asp Val  Phe Tyr Leu Gln Pro  Glu Arg Ser Cys Val  Pro Asn Ser 
    1490                 1495                 1500             


Pro Met  Trp Tyr Ser Thr Phe  Pro Ile Asp Pro Gly  Thr Leu Asp 
    1505                 1510                 1515             


Thr Met  Leu Thr Arg Ile Leu  Met Val Arg Glu Val  His Glu Glu 
    1520                 1525                 1530             


Leu Ala  Lys Ala Lys Ser Glu  Asp Ser Asp Val Glu  Leu Ser Asp 
    1535                 1540                 1545             


<210>  5840
<211>  6113
<212>  DNA
<213>  Homosapiens

<400>  5840
caaaaaagtg gtgcagtttt tgatgaaatt gtagagaact gagtatagtc atggccaaca     60

gcaaaaaact caagaggggg aactgaaaat tagtgctgtg ttttcagtca gtggcagccc    120

tcttgctcca cagttgacta ctggctttca gccctcactg gcgtcatctg gcatgaataa    180

aatgcttcct tcagttccag ccacagctgt tcgagtttcc tgttctggtt gtaaaaaaat    240

cctccagaag gggcaaactg cttatcagag gaaagggtct actcagctat tctgctccac    300

actgtgcctc actggatata cagttccacc tgcccgccca ccgcctcctc tcaccaagaa    360

aacttgttca agttgctcaa aagacatttt aaatccaaag gatgtgatca gtgcccagtt    420

tgaaaacacc accactagta aagatttttg cagtcagtca tgtttgtcaa catatgaact    480

gaaaaaaaaa cctattgtta ccataaatac aaatagtatt tcaaccaaat gcagcatgtg    540

tcagaagaat gctgttattc gacatgaagt taattaccag aatgtggtcc ataaactttg    600

cagtgatgcc tgcttctcta agtttcgttc tgctaacaac ctcaccatga actgttgtga    660

gaactgtggg ggttactgtt acagtgggtc gggacaatgc cacatgcttc agatagaggg    720

acagtctaag aagttttgta gttcatcgtg tatcacggca tacaagcaga aatcagccaa    780

aattacaccg tgtgcgcttt gcaaatcatt gagatcctca gcagaaatga ttgaaaatac    840

caatagcttg gggaagacag agcttttctg ttctgttaat tgcttatctg cttacagagt    900

taaaatggtt acttctgcag gtgtacaagt tcagtgtaac agttgtaaaa cctcagcaat    960

tcctcagtat cacctagcca tgtcagatgg aagtatacgc aacttctgca gctacagctg   1020

tgtggtagct ttccagaatt tattcaacaa accaactgga atgaattctt cagtagtgcc   1080

cttgtctcag ggccaagtaa ttgtaagcat ccccacaggt tccacagtgt cagccggagg   1140

aggtagcaca tctgctgttt ctcccacctc catcagtagc tctgctgcag ctggtctcca   1200

gcgtctcgct gcccagtccc agcatgttgg gtttgcacga agtgttgtga aactcaaatg   1260

tcaacactgt aaccgtcttt ttgccacaaa accagaactt cttgactata agggcaaaat   1320

gtttcagttc tgtggcaaga attgttctga tgaatataag aaaataaata atgtaatggc   1380

aatgtgtgaa tattgtaaaa ttgagaaaat tgtaaaggag actgttcggt tctcaggtgc   1440

tgacaagtca ttctgtagtg aaggttgcaa attgctttat aaacatgact tggcaaaacg   1500

ctggggaaat cactgtaaaa tgtgcagtta ttgtttacag acatctccca aattggtaca   1560

gaataattta ggagggaaag tggaagagtt ctgttgtgaa gaatgcatgt ccaaatatac   1620

agttttgttc tatcagatgg ccaaatgtga tgcttgtaag cgacagggta aactcagtga   1680

gtccttgaaa tggcgagggg aaatgaaaca tttctgtaac ctgctttgta tcttgatgtt   1740

ctgtaatcag caaagtgtat gtgacccgcc ttcacaaaat aatgcagcaa atatttccat   1800

ggttcaagct gcttcagcag gacccccatc tctgagaaaa gattcgactc cagttatagc   1860

caatgtagta tcattggcaa gtgcccctgc tgctcagcct acagtgaatt ctaacagtgt   1920

cttacaaggt gcagttccaa cagtaacagc gaaaatcatc ggtgatgcaa gtactcaaac   1980

agatgccctg aaactgccac cttcccaacc tccaaggctt ttgaagaaca aagctttatt   2040

atgcaaaccc atcacacaga ctaaagccac ctcttgcaaa ccacataccc aaaacaaaga   2100

atgccagaca gaagacactc caagtcagcc ccagattatt gtggtgccag ttcccgtacc   2160

agtgtttgtt cccatacctc ttcaccttta tactcaatat gctccagtcc catttggaat   2220

tccagttcca atgcctgtcc ctatgcttat tccatcttca atggatagtg aagataaagt   2280

cacagagagt attgaagaca ttaaagaaaa gcttcccaca catccatttg aagctgatct   2340

ccttgagatg gcagaaatga ttgcagaaga tgaagagaag aagactctat ctcagggaga   2400

gtcccaaact tctgaacacg aactctttct agacaccaag atatttgaaa aagaccaagg   2460

aagtacatac agtggtgatc ttgaatcaga ggcagtatct actccacata gctgggagga   2520

agagctgaat cactatgcct taaagtcaaa tgctgtgcaa gaggctgatt cagaattgaa   2580

gcagttctca aaaggggaaa ctgaacagga cctggaagca gattttccat cagactcctt   2640

tgacccactt aataaaggac agggaatcca ggcacgttcc cgaacaagac gacgacacag   2700

agatggcttc ccccaaccca gacgaagagg acggaagaag tctatagtgg ctgtggagcc   2760

caggagtctt attcaaggag cctttcaagg ctgctcagtg tccgggatga cactgaaata   2820

catgtatggg gtaaatgctt ggaagaactg ggttcagtgg aaaaatgcca aggaagagca   2880

gggggatcta aaatgtggag gggttgaaca ggcctcatct agcccacgtt ctgacccctt   2940

aggaagtact caagaccatg cactctctca agaatcctca gagccaggct gtagagtccg   3000

ctctatcaag ctgaaggaag acattctgtc ctgcactttt gctgagttga gtttgggctt   3060

atgccagttt atccaagagg tgcggagacc aaatggtgaa aaatatgatc cagacagtat   3120

cttatacttg tgccttggaa ttcaacagta cctgtttgaa aatggtagaa tagataacat   3180

ttttactgag ccctattcca gatttatgat tgaacttacc aaactcttga aaatatggga   3240

acctacaata cttcctaatg gttacatgtt ctctcgcatt gaggaagagc atttgtggga   3300

gtgcaaacag ctgggcgctt actcaccaat cgtcctttta aacaccctcc ttttcttcaa   3360

taccaaatac ttccaactaa agaatgttac tgagcacttg aagctttcct ttgcccatgt   3420

gatgagacgg accaggactc tgaagtacag taccaagatg acatatctga ggttcttccc   3480

acctttacag aagcaggagt cagaaccaga taaactgact gttggcaaga ggaaacgaaa   3540

tgaagatgat gaggttccag tgggggtgga gatggcagag aatactgaca atccactaag   3600

atgcccagtc cgactttatg agttttacct gtcaaaatgt tctgaaagtg tgaagcaaag   3660

gaatgatgtg ttttaccttc aacctgagcg ctcctgtgtc ccgaatagcc ccatgtggta   3720

ctccacattc ccgatagacc ctggaaccct ggacaccatg ttaacacgta ttctcatggt   3780

gagggaggta catgaagaac ttgccaaagc caaatctgaa gactctgatg ttgaattatc   3840

agattaaaac ggaagtgagg ttcttatttt catacatatt ggtatgcacc aaactgtgaa   3900

tgcatccagc tgttggaaaa tgatgtataa gtctaagtcc tcttgacttg accataagat   3960

catggaaaac agatgacttg tgaaccccac agtgtggatg tgcaaatgaa aattgaagga   4020

aagaatatga actgagaaat gttctttggc agtgatatag ttcttagaca tcttcagaat   4080

gactaatttc tccgagtggt gcataatctt attttgtttg ggagtaacaa atcgtggaat   4140

atttttaagg aaaactgttg tataaaactt taccatagta accttagacc ttagagaggt   4200

agctttggag tgaaactttg gctgcaatag gctactttgg caagccctcc gtaaaagtca   4260

gaggagagat cagtacagag ctaagagtga catcaaatga ggactgtggg acccagattt   4320

gaagacccaa taaaaatact caacttttta aaaaagatag tgaagtggtc ttgattgatt   4380

ttgattttca ctgccaagcc aatcatgtga aggacagaag cttttgccat gggcccctca   4440

catcagggaa aatgaccttc actgctgtta acagtaatgt gtccctttca ttttctggat   4500

caagccttct cagcggtggg tctggatgtg ggtaaactaa ggtaaagggg atgatattcc   4560

acaaactaat tatgcacaca gaaaatctgt ggagcctatc agaccccaag tgtcttgaaa   4620

tgtttgtaga aacccactaa aatgcccctt ctctgggtgt gggcccttat tgcagctgtc   4680

tcacagcctg agctgtggta cagagaaatg ggggttctcc ttttattttc attttttttc   4740

cccaatggca gcttttctcc cgttgtttta ccttcctatt tcccaaacag ttcctcttat   4800

tttgtctttt gcaccagttt ctggaggccc ttgtcatttc aaaaaggata gtctcttttc   4860

ttactctggc aaacctgtga gtgattccac aaagatacag tattacttag ctatctgaat   4920

tatgatagaa aaggtcctag ttaggttcct atataaagca tttggaagat gaccttgttg   4980

cccttgaaac ttgaaaatag ggattctggg gtgaggatac aaagacattg tcttgcatat   5040

ccataagcag gtcttagagc attattccaa actctagctg tttcagtagt tctatgagga   5100

ttgcaagtca taggtgtgtg tggcatatca gtccatctcc ctcatctcca ttctcagttt   5160

cttccccaca aaatttggaa tcaaagcttt tatgacgttt gccaattgca gaacttcttc   5220

agctaaggtt aatttgacgc tatgataaaa ctgagagatg tcaaaaagcc tcttagaaat   5280

tttaatcttg aaagactttt cagggtatct cattttttag gtgggggtgg caggtgtatt   5340

tcttttttaa caaataaaag gcatttaagt aaaactaaaa tgaaaaaagt aggccttctg   5400

acattgtgta cttggtggtt ctgtccctct gcctgtaaca aatctcattt ttgttaccaa   5460

gaactgtatg aaagaagtaa atccaccccg attctgtatg attaattcca tctgtgtttg   5520

tcatttctga ctggaaaact tcttactcca taccttgttc gatatggagg acaaataatt   5580

ggattgtctg ataagtctgc caataaacta tccagaaata gcaagtgtaa tagtccccac   5640

tatacgaatt ttatggtttg tataaacact aacattttcc ccttctgtag ttgtatgaaa   5700

aaacaaatat tgttagcata gtagataaat tgttatgaaa taccagaaaa aaaaatctgt   5760

atcttttact gagaacaccc aatacccaga taaatgactg tatcaggatt tcatttgcat   5820

gttagtccac agagttgccc agaaccctaa atttattcat aagagaaaat attgattaat   5880

tattggtcat tcctcataag tgtagctgtt gatgtgtgcg tctgattatt gcttttttaa   5940

ttttatgaaa attgtgtaaa attacatttt ttttccaggg gagaaaaaaa catcaaacaa   6000

aaacatctaa atcatccttt ttgttctttt tcagttttta accactttta ggttttcccc   6060

ttacagaaac cacagaaata ttcccttaga ataaaatagt atatttgtat ttg          6113


<210>  5841
<211>  1224
<212>  PRT
<213>  Homosapiens

<400>  5841

Met Asn Lys Met Leu Pro Ser Val Pro Ala Thr Ala Val Arg Val Ser 
1               5                   10                  15      


Cys Ser Gly Cys Lys Lys Ile Leu Gln Lys Gly Gln Thr Ala Tyr Gln 
            20                  25                  30          


Arg Lys Gly Ser Thr Gln Leu Phe Cys Ser Thr Leu Cys Leu Thr Gly 
        35                  40                  45              


Tyr Thr Val Pro Pro Ala Arg Pro Pro Pro Pro Leu Thr Lys Lys Thr 
    50                  55                  60                  


Cys Ser Ser Cys Ser Lys Asp Ile Leu Asn Pro Lys Asp Val Ile Ser 
65                  70                  75                  80  


Ala Gln Phe Glu Asn Thr Thr Thr Ser Lys Asp Phe Cys Ser Gln Ser 
                85                  90                  95      


Cys Leu Ser Thr Tyr Glu Leu Lys Lys Lys Pro Ile Val Thr Ile Asn 
            100                 105                 110         


Thr Asn Ser Ile Ser Thr Lys Cys Ser Met Cys Gln Lys Asn Ala Val 
        115                 120                 125             


Ile Arg His Glu Val Asn Tyr Gln Asn Val Val His Lys Leu Cys Ser 
    130                 135                 140                 


Asp Ala Cys Phe Ser Lys Phe Arg Ser Ala Asn Asn Leu Thr Met Asn 
145                 150                 155                 160 


Cys Cys Glu Asn Cys Gly Gly Tyr Cys Tyr Ser Gly Ser Gly Gln Cys 
                165                 170                 175     


His Met Leu Gln Ile Glu Gly Gln Ser Lys Lys Phe Cys Ser Ser Ser 
            180                 185                 190         


Cys Ile Thr Ala Tyr Lys Gln Lys Ser Ala Lys Ile Thr Pro Cys Ala 
        195                 200                 205             


Leu Cys Lys Ser Leu Arg Ser Ser Ala Glu Met Ile Glu Asn Thr Asn 
    210                 215                 220                 


Ser Leu Gly Lys Thr Glu Leu Phe Cys Ser Val Asn Cys Leu Ser Ala 
225                 230                 235                 240 


Tyr Arg Val Lys Met Val Thr Ser Ala Gly Val Gln Val Gln Cys Asn 
                245                 250                 255     


Ser Cys Lys Thr Ser Ala Ile Pro Gln Tyr His Leu Ala Met Ser Asp 
            260                 265                 270         


Gly Ser Ile Arg Asn Phe Cys Ser Tyr Ser Cys Val Val Ala Phe Gln 
        275                 280                 285             


Asn Leu Phe Asn Lys Pro Thr Gly Met Asn Ser Ser Val Val Pro Leu 
    290                 295                 300                 


Ser Gln Gly Gln Val Ile Val Ser Ile Pro Thr Gly Ser Thr Val Ser 
305                 310                 315                 320 


Ala Gly Gly Gly Ser Thr Ser Ala Val Ser Pro Thr Ser Ile Ser Ser 
                325                 330                 335     


Ser Ala Ala Ala Gly Leu Gln Arg Leu Ala Ala Gln Ser Gln His Val 
            340                 345                 350         


Gly Phe Ala Arg Ser Val Val Lys Leu Lys Cys Gln His Cys Asn Arg 
        355                 360                 365             


Leu Phe Ala Thr Lys Pro Glu Leu Leu Asp Tyr Lys Gly Lys Met Phe 
    370                 375                 380                 


Gln Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys Lys Ile Asn Asn 
385                 390                 395                 400 


Val Met Ala Met Cys Glu Tyr Cys Lys Ile Glu Lys Ile Val Lys Glu 
                405                 410                 415     


Thr Val Arg Phe Ser Gly Ala Asp Lys Ser Phe Cys Ser Glu Gly Cys 
            420                 425                 430         


Lys Leu Leu Tyr Lys His Asp Leu Ala Lys Arg Trp Gly Asn His Cys 
        435                 440                 445             


Lys Met Cys Ser Tyr Cys Leu Gln Thr Ser Pro Lys Leu Val Gln Asn 
    450                 455                 460                 


Asn Leu Gly Gly Lys Val Glu Glu Phe Cys Cys Glu Glu Cys Met Ser 
465                 470                 475                 480 


Lys Tyr Thr Val Leu Phe Tyr Gln Met Ala Lys Cys Asp Ala Cys Lys 
                485                 490                 495     


Arg Gln Gly Lys Leu Ser Glu Ser Leu Lys Trp Arg Gly Glu Met Lys 
            500                 505                 510         


His Phe Cys Asn Leu Leu Cys Ile Leu Met Phe Cys Asn Gln Gln Ser 
        515                 520                 525             


Val Cys Asp Pro Pro Ser Gln Asn Asn Ala Ala Asn Ile Ser Met Val 
    530                 535                 540                 


Gln Ala Ala Ser Ala Gly Pro Pro Ser Leu Arg Lys Asp Ser Thr Pro 
545                 550                 555                 560 


Val Ile Ala Asn Val Val Ser Leu Ala Ser Ala Pro Ala Ala Gln Pro 
                565                 570                 575     


Thr Val Asn Ser Asn Ser Val Leu Gln Gly Ala Val Pro Thr Val Thr 
            580                 585                 590         


Ala Lys Ile Ile Gly Asp Ala Ser Thr Gln Thr Asp Ala Leu Lys Leu 
        595                 600                 605             


Pro Pro Ser Gln Pro Pro Arg Leu Leu Lys Asn Lys Ala Leu Leu Cys 
    610                 615                 620                 


Lys Pro Ile Thr Gln Thr Lys Ala Thr Ser Cys Lys Pro His Thr Gln 
625                 630                 635                 640 


Asn Lys Glu Cys Gln Thr Glu Asp Thr Pro Ser Gln Pro Gln Ile Ile 
                645                 650                 655     


Val Val Pro Val Pro Val Pro Val Phe Val Pro Ile Pro Leu His Leu 
            660                 665                 670         


Tyr Thr Gln Tyr Ala Pro Val Pro Phe Gly Ile Pro Val Pro Met Pro 
        675                 680                 685             


Val Pro Met Leu Ile Pro Ser Ser Met Asp Ser Glu Asp Lys Val Thr 
    690                 695                 700                 


Glu Ser Ile Glu Asp Ile Lys Glu Lys Leu Pro Thr His Pro Phe Glu 
705                 710                 715                 720 


Ala Asp Leu Leu Glu Met Ala Glu Met Ile Ala Glu Asp Glu Glu Lys 
                725                 730                 735     


Lys Thr Leu Ser Gln Gly Glu Ser Gln Thr Ser Glu His Glu Leu Phe 
            740                 745                 750         


Leu Asp Thr Lys Ile Phe Glu Lys Asp Gln Gly Ser Thr Tyr Ser Gly 
        755                 760                 765             


Asp Leu Glu Ser Glu Ala Val Ser Thr Pro His Ser Trp Glu Glu Glu 
    770                 775                 780                 


Leu Asn His Tyr Ala Leu Lys Ser Asn Ala Val Gln Glu Ala Asp Ser 
785                 790                 795                 800 


Glu Leu Lys Gln Phe Ser Lys Gly Glu Thr Glu Gln Asp Leu Glu Ala 
                805                 810                 815     


Asp Phe Pro Ser Asp Ser Phe Asp Pro Leu Asn Lys Gly Gln Gly Ile 
            820                 825                 830         


Gln Ala Arg Ser Arg Thr Arg Arg Arg His Arg Asp Gly Phe Pro Gln 
        835                 840                 845             


Pro Arg Arg Arg Gly Arg Lys Lys Ser Ile Val Ala Val Glu Pro Arg 
    850                 855                 860                 


Ser Leu Ile Gln Gly Ala Phe Gln Gly Cys Ser Val Ser Gly Met Thr 
865                 870                 875                 880 


Leu Lys Tyr Met Tyr Gly Val Asn Ala Trp Lys Asn Trp Val Gln Trp 
                885                 890                 895     


Lys Asn Ala Lys Glu Glu Gln Gly Asp Leu Lys Cys Gly Gly Val Glu 
            900                 905                 910         


Gln Ala Ser Ser Ser Pro Arg Ser Asp Pro Leu Gly Ser Thr Gln Asp 
        915                 920                 925             


His Ala Leu Ser Gln Glu Ser Ser Glu Pro Gly Cys Arg Val Arg Ser 
    930                 935                 940                 


Ile Lys Leu Lys Glu Asp Ile Leu Ser Cys Thr Phe Ala Glu Leu Ser 
945                 950                 955                 960 


Leu Gly Leu Cys Gln Phe Ile Gln Glu Val Arg Arg Pro Asn Gly Glu 
                965                 970                 975     


Lys Tyr Asp Pro Asp Ser Ile Leu Tyr Leu Cys Leu Gly Ile Gln Gln 
            980                 985                 990         


Tyr Leu Phe Glu Asn Gly Arg Ile  Asp Asn Ile Phe Thr  Glu Pro Tyr 
        995                 1000                 1005             


Ser Arg  Phe Met Ile Glu Leu  Thr Lys Leu Leu Lys  Ile Trp Glu 
    1010                 1015                 1020             


Pro Thr  Ile Leu Pro Asn Gly  Tyr Met Phe Ser Arg  Ile Glu Glu 
    1025                 1030                 1035             


Glu His  Leu Trp Glu Cys Lys  Gln Leu Gly Ala Tyr  Ser Pro Ile 
    1040                 1045                 1050             


Val Leu  Leu Asn Thr Leu Leu  Phe Phe Asn Thr Lys  Tyr Phe Gln 
    1055                 1060                 1065             


Leu Lys  Asn Val Thr Glu His  Leu Lys Leu Ser Phe  Ala His Val 
    1070                 1075                 1080             


Met Arg  Arg Thr Arg Thr Leu  Lys Tyr Ser Thr Lys  Met Thr Tyr 
    1085                 1090                 1095             


Leu Arg  Phe Phe Pro Pro Leu  Gln Lys Gln Glu Ser  Glu Pro Asp 
    1100                 1105                 1110             


Lys Leu  Thr Val Gly Lys Arg  Lys Arg Asn Glu Asp  Asp Glu Val 
    1115                 1120                 1125             


Pro Val  Gly Val Glu Met Ala  Glu Asn Thr Asp Asn  Pro Leu Arg 
    1130                 1135                 1140             


Cys Pro  Val Arg Leu Tyr Glu  Phe Tyr Leu Ser Lys  Cys Ser Glu 
    1145                 1150                 1155             


Ser Val  Lys Gln Arg Asn Asp  Val Phe Tyr Leu Gln  Pro Glu Arg 
    1160                 1165                 1170             


Ser Cys  Val Pro Asn Ser Pro  Met Trp Tyr Ser Thr  Phe Pro Ile 
    1175                 1180                 1185             


Asp Pro  Gly Thr Leu Asp Thr  Met Leu Thr Arg Ile  Leu Met Val 
    1190                 1195                 1200             


Arg Glu  Val His Glu Glu Leu  Ala Lys Ala Lys Ser  Glu Asp Ser 
    1205                 1210                 1215             


Asp Val  Glu Leu Ser Asp 
    1220                 


<210>  5842
<211>  6303
<212>  DNA
<213>  Homosapiens

<400>  5842
caaaaaagtg gtgcagtttt tgatgaaatt gtagagaact gagtatagtc atggccaaca     60

gcaaaaaact caagaggggg aactgaaaat tagtgctgtg ttttcagtca gtggcagccc    120

tcttgctcca cagttgacta ctggctttca gccctcactg gcgtcatctg gcatgaataa    180

aatgcttcct tcagttccag ccacagctgt tcgagtttcc tgttctggtt gtaaaaaaat    240

cctccagaag gggcaaactg cttatcagag gaaagggtct actcagctat tctgctccac    300

actgtgcctc actggatata cagttccacc tgcccgccca ccgcctcctc tcaccaagaa    360

aacttgttca agttgctcaa aagacatttt aaatccaaag gatgtgatca gtgcccagtt    420

tgaaaacacc accactagta aagatttttg cagtcagtca tgtttgtcaa catatgaact    480

gaaaaaaaaa cctattgtta ccataaatac aaatagtatt tcaaccaaat gcagcatgtg    540

tcagaagaat gctgttattc gacatgaagt taattaccag aatgtggtcc ataaactttg    600

cagtgatgcc tgcttctcta agtttcgttc tgctaacaac ctcaccatga actgttgtga    660

gaactgtggg ggttactgtt acagtgggtc gggacaatgc cacatgcttc agatagaggg    720

acagtctaag aagttttgta gttcatcgtg tatcacggca tacaagcaga aatcagccaa    780

aattacaccg tgtgcgcttt gcaaatcatt gagatcctca gcagaaatga ttgaaaatac    840

caatagcttg gggaagacag agcttttctg ttctgttaat tgcttatctg cttacagagt    900

taaaatggtt acttctgcag gtgtacaagt tcagtgtaac agttgtaaaa cctcagcaat    960

tcctcagtat cacctagcca tgtcagatgg aagtatacgc aacttctgca gctacagctg   1020

tgtggtagct ttccagaatt tattcaacaa accaactgga atgaattctt cagtagtgcc   1080

cttgtctcag ggccaagtaa ttgtaagcat ccccacaggt tccacagtgt cagccggagg   1140

aggtagcaca tctgctgttt ctcccacctc catcagtagc tctgctgcag ctggtctcca   1200

gcgtctcgct gcccagtccc agcatgttgg gtttgcacga agtgttgtga aactcaaatg   1260

tcaacactgt aaccgtcttt ttgccacaaa accagaactt cttgactata agggcaaaat   1320

gtttcagttc tgtggcaaga attgttctga tgaatataag aaaataaata atgtaatggc   1380

aatgtgtgaa tattgtaaaa ttgagaaaat tgtaaaggag actgttcggt tctcaggtgc   1440

tgacaagtca ttctgtagtg aaggttgcaa attgctttat aaacatgact tggcaaaacg   1500

ctggggaaat cactgtaaaa tgtgcagtta ttgtttacag acatctccca aattggtaca   1560

gaataattta ggagggaaag tggaagagtt ctgttgtgaa gaatgcatgt ccaaatatac   1620

agttttgttc tatcagatgg ccaaatgtga tgcttgtaag cgacagggta aactcagtga   1680

gtccttgaaa tggcgagggg aaatgaaaca tttctgtaac ctgctttgta tcttgatgtt   1740

ctgtaatcag caaagtgtat gtgacccgcc ttcacaaaat aatgcagcaa atatttccat   1800

ggttcaagct gcttcagcag gacccccatc tctgagaaaa gattcgactc cagttatagc   1860

caatgtagta tcattggcaa gtgcccctgc tgctcagcct acagtgaatt ctaacagtgt   1920

cttacaaggt gcagttccaa cagtaacagc gaaaatcatc ggtgatgcaa gtactcaaac   1980

agatgccctg aaactgccac cttcccaacc tccaaggctt ttgaagaaca aagctttatt   2040

atgcaaaccc atcacacaga ctaaagccac ctcttgcaaa ccacataccc aaaacaaaga   2100

atgccagaca gaagacactc caagtcagcc ccagattatt gtggtgccag ttcccgtacc   2160

agtgtttgtt cccatacctc ttcaccttta tactcaatat gctccagtcc catttggaat   2220

tccagttcca atgcctgtcc ctatgcttat tccatcttca atggatagtg aagataaagt   2280

cacagagagt attgaagaca ttaaagaaaa gcttcccaca catccatttg aagctgatct   2340

ccttgagatg gcagaaatga ttgcagaaga tgaagagaag aagactctat ctcagggaga   2400

gtcccaaact tctgaacacg aactctttct agacaccaag atatttgaaa aagaccaagg   2460

aagtacatac agtggtgatc ttgaatcaga ggcagtatct actccacata gctgggagga   2520

agagctgaat cactatgcct taaagtcaaa tgctgtgcaa gaggctgatt cagaattgaa   2580

gcagttctca aaaggggaaa ctgaacagga cctggaagca gattttccat cagactcctt   2640

tgacccactt aataaaggac agggaatcca ggcacgttcc cgaacaagac gacgacacag   2700

agatggcttc ccccaaccca gacgaagagg acggaagaag tctatagtgg ctgtggagcc   2760

caggagtctt attcaaggag cctttcaagg ctgctcagtg tccgggatga cactgaaata   2820

catgtatggg gtaaatgctt ggaagaactg ggttcagtgg aaaaatgcca aggaagagca   2880

gggggatcta aaatgtggag gggttgaaca ggcctcatct agcccacgtt ctgacccctt   2940

aggaagtact caagaccatg cactctctca agaatcctca gagccaggct gtagagtccg   3000

ctctatcaag ctgaaggaag acattctgtc ctgcactttt gctgagttga gtttgggctt   3060

atgccagttt atccaagagg tgcggagacc aaatggtgaa aaatatgatc cagacagtat   3120

cttatacttg tgccttggaa ttcaacagta cctgtttgaa aatggtagaa tagataacat   3180

ttttactgag ccctattcca gatttatgat tgaacttacc aaactcttga aaatatggga   3240

acctacaata cttcctaatg gttacatgtt ctctcgcatt gaggaagagc atttgtggga   3300

gtgcaaacag ctgggcgctt actcaccaat cgtcctttta aacaccctcc ttttcttcaa   3360

taccaaatac ttccaactaa agaatgttac tgagcacttg aagctttcct ttgcccatgt   3420

gatgagacgg accaggactc tgaagtacag taccaagatg acatatctga ggttcttccc   3480

acctttacag aagcaggagt cagaaccaga taaactgact gttggcaaga ggaaacgaaa   3540

tgaagatgat gaggttccag tgggggtgga gatggcagag aatactgaca atccactaag   3600

atgcccagtc cgactttatg agttttacct gtcaaaatgt tctgaaagtg tgaagcaaag   3660

gaatgatgtg ttttaccttc aacctgagcg ctcctgtgtc ccgaatagcc ccatgtggta   3720

ctccacattc ccgatagacc ctggaaccct ggacaccatg ttaacacgta ttctcatggt   3780

gagggaggta catgaagaac ttgccaaagc caaatctgaa gactctgatg ttgaattatc   3840

agattaaaac ggaagtgagg ttcttatttt catacatatt ggtatgcacc aaactgtgaa   3900

tgcatccagc tgttggaaaa tgatgtataa gtctaagtcc tcttgacttg accataagat   3960

catggaaaac agatgacttg tgaaccccac agtgtggatg tgcaaatgaa aattgaagga   4020

aagaatatga actgagaaat gttctttggc agtgatatag ttcttagaca tcttcagaat   4080

gactaatttc tccgagtggt gcataatctt attttgtttg ggagtaacaa atcgtggaat   4140

atttttaagg aaaactgttg tataaaactt taccatagta accttagacc ttagagaggt   4200

agctttggag tgaaactttg gctgcaatag gctactttgg caagccctcc gtaaaagtca   4260

gaggagagat cagtacagag ctaagagtga catcaaatga ggactgtggg acccagattt   4320

gaagacccaa taaaaatact caacttttta aaaaagatag tgaagtggtc ttgattgatt   4380

ttgattttca ctgccaagcc aatcatgtga aggacagaag cttttgccat gggcccctca   4440

catcagggaa aatgaccttc actgctgtta acagtaatgt gtccctttca ttttctggat   4500

caagccttct cagcggtggg tctggatgtg ggtaaactaa ggtaaagggg atgatattcc   4560

acaaactaat tatgcacaca gaaaatctgt ggagcctatc agaccccaag tgtcttgaaa   4620

tgtttgtaga aacccactaa aatgcccctt ctctgggtgt gggcccttat tgcagctgtc   4680

tcacagcctg agctgtggta cagagaaatg ggggttctcc ttttattttc attttttttc   4740

cccaatggca gcttttctcc cgttgtttta ccttcctatt tcccaaacag ttcctcttat   4800

tttgtctttt gcaccagttt ctggaggccc ttgtcatttc aaaaaggata gtctcttttc   4860

ttactctggc aaacctgtga gtgattccac aaagatacag tattacttag ctatctgaat   4920

tatgatagaa aaggtcctag ttaggttcct atataaagca tttggaagat gaccttgttg   4980

cccttgaaac ttgaaaatag ggattctggg gtgaggatac aaagacattg tcttgcatat   5040

ccataagcag gtcttagagc attattccaa actctagctg tttcagtagt tctatgagga   5100

ttgcaagtca taggtgtgtg tggcatatca gtccatctcc ctcatctcca ttctcagttt   5160

cttccccaca aaatttggaa tcaaagcttt tatgacgttt gccaattgca gaacttcttc   5220

agctaaggtt aatttgacgc tatgataaaa ctgagagatg tcaaaaagcc tcttagaaat   5280

tttaatcttg aaagactttt cagggtatct cattttttag gtgggggtgg caggtgtatt   5340

tcttttttaa caaataaaag gcatttaagt aaaactaaaa tgaaaaaagt aggccttctg   5400

acattgtgta cttggtggtt ctgtccctct gcctgtaaca aatctcattt ttgttaccaa   5460

gaactgtatg aaagaagtaa atccaccccg attctgtatg attaattcca tctgtgtttg   5520

tcatttctga ctggaaaact tcttactcca taccttgttc gatatggagg acaaataatt   5580

ggattgtctg ataagtctgc caataaacta tccagaaata gcaagtgtaa tagtccccac   5640

tatacgaatt ttatggtttg tataaacact aacattttcc ccttctgtag ttgtatgaaa   5700

aaacaaatat tgttagcata gtagataaat tgttatgaaa taccagaaaa aaaaatctgt   5760

atcttttact gagaacaccc aatacccaga taaatgactg tatcaggatt tcatttgcat   5820

gttagtccac agagttgccc agaaccctaa atttattcat aagagaaaat attgattaat   5880

tattggtcat tcctcataag tgtagctgtt gatgtgtgcg tctgattatt gcttttttaa   5940

ttttatgaaa attgtgtaaa attacatttt ttttccaggg gagaaaaaaa catcaaacaa   6000

aaacatctaa atcatccttt ttgttctttt tcagttttta accactttta ggttttcccc   6060

ttacagaaac cacagaaata ttcccttaga ataaaatagt atatttgtat ttgatgggtg   6120

agttcttctt ctttacgtct taaaagaatt tgaaatctct ttttctgatt gaccttattg   6180

gtatgaccca gcaattagta aaattacaaa gaaagagagc agtttccgag aaagaaattt   6240

tttttatgta gtccagtcaa catatttttt cattgcaagt tcttttattt ccttttttcc   6300

atc                                                                 6303


<210>  5843
<211>  1224
<212>  PRT
<213>  Homosapiens

<400>  5843

Met Asn Lys Met Leu Pro Ser Val Pro Ala Thr Ala Val Arg Val Ser 
1               5                   10                  15      


Cys Ser Gly Cys Lys Lys Ile Leu Gln Lys Gly Gln Thr Ala Tyr Gln 
            20                  25                  30          


Arg Lys Gly Ser Thr Gln Leu Phe Cys Ser Thr Leu Cys Leu Thr Gly 
        35                  40                  45              


Tyr Thr Val Pro Pro Ala Arg Pro Pro Pro Pro Leu Thr Lys Lys Thr 
    50                  55                  60                  


Cys Ser Ser Cys Ser Lys Asp Ile Leu Asn Pro Lys Asp Val Ile Ser 
65                  70                  75                  80  


Ala Gln Phe Glu Asn Thr Thr Thr Ser Lys Asp Phe Cys Ser Gln Ser 
                85                  90                  95      


Cys Leu Ser Thr Tyr Glu Leu Lys Lys Lys Pro Ile Val Thr Ile Asn 
            100                 105                 110         


Thr Asn Ser Ile Ser Thr Lys Cys Ser Met Cys Gln Lys Asn Ala Val 
        115                 120                 125             


Ile Arg His Glu Val Asn Tyr Gln Asn Val Val His Lys Leu Cys Ser 
    130                 135                 140                 


Asp Ala Cys Phe Ser Lys Phe Arg Ser Ala Asn Asn Leu Thr Met Asn 
145                 150                 155                 160 


Cys Cys Glu Asn Cys Gly Gly Tyr Cys Tyr Ser Gly Ser Gly Gln Cys 
                165                 170                 175     


His Met Leu Gln Ile Glu Gly Gln Ser Lys Lys Phe Cys Ser Ser Ser 
            180                 185                 190         


Cys Ile Thr Ala Tyr Lys Gln Lys Ser Ala Lys Ile Thr Pro Cys Ala 
        195                 200                 205             


Leu Cys Lys Ser Leu Arg Ser Ser Ala Glu Met Ile Glu Asn Thr Asn 
    210                 215                 220                 


Ser Leu Gly Lys Thr Glu Leu Phe Cys Ser Val Asn Cys Leu Ser Ala 
225                 230                 235                 240 


Tyr Arg Val Lys Met Val Thr Ser Ala Gly Val Gln Val Gln Cys Asn 
                245                 250                 255     


Ser Cys Lys Thr Ser Ala Ile Pro Gln Tyr His Leu Ala Met Ser Asp 
            260                 265                 270         


Gly Ser Ile Arg Asn Phe Cys Ser Tyr Ser Cys Val Val Ala Phe Gln 
        275                 280                 285             


Asn Leu Phe Asn Lys Pro Thr Gly Met Asn Ser Ser Val Val Pro Leu 
    290                 295                 300                 


Ser Gln Gly Gln Val Ile Val Ser Ile Pro Thr Gly Ser Thr Val Ser 
305                 310                 315                 320 


Ala Gly Gly Gly Ser Thr Ser Ala Val Ser Pro Thr Ser Ile Ser Ser 
                325                 330                 335     


Ser Ala Ala Ala Gly Leu Gln Arg Leu Ala Ala Gln Ser Gln His Val 
            340                 345                 350         


Gly Phe Ala Arg Ser Val Val Lys Leu Lys Cys Gln His Cys Asn Arg 
        355                 360                 365             


Leu Phe Ala Thr Lys Pro Glu Leu Leu Asp Tyr Lys Gly Lys Met Phe 
    370                 375                 380                 


Gln Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys Lys Ile Asn Asn 
385                 390                 395                 400 


Val Met Ala Met Cys Glu Tyr Cys Lys Ile Glu Lys Ile Val Lys Glu 
                405                 410                 415     


Thr Val Arg Phe Ser Gly Ala Asp Lys Ser Phe Cys Ser Glu Gly Cys 
            420                 425                 430         


Lys Leu Leu Tyr Lys His Asp Leu Ala Lys Arg Trp Gly Asn His Cys 
        435                 440                 445             


Lys Met Cys Ser Tyr Cys Leu Gln Thr Ser Pro Lys Leu Val Gln Asn 
    450                 455                 460                 


Asn Leu Gly Gly Lys Val Glu Glu Phe Cys Cys Glu Glu Cys Met Ser 
465                 470                 475                 480 


Lys Tyr Thr Val Leu Phe Tyr Gln Met Ala Lys Cys Asp Ala Cys Lys 
                485                 490                 495     


Arg Gln Gly Lys Leu Ser Glu Ser Leu Lys Trp Arg Gly Glu Met Lys 
            500                 505                 510         


His Phe Cys Asn Leu Leu Cys Ile Leu Met Phe Cys Asn Gln Gln Ser 
        515                 520                 525             


Val Cys Asp Pro Pro Ser Gln Asn Asn Ala Ala Asn Ile Ser Met Val 
    530                 535                 540                 


Gln Ala Ala Ser Ala Gly Pro Pro Ser Leu Arg Lys Asp Ser Thr Pro 
545                 550                 555                 560 


Val Ile Ala Asn Val Val Ser Leu Ala Ser Ala Pro Ala Ala Gln Pro 
                565                 570                 575     


Thr Val Asn Ser Asn Ser Val Leu Gln Gly Ala Val Pro Thr Val Thr 
            580                 585                 590         


Ala Lys Ile Ile Gly Asp Ala Ser Thr Gln Thr Asp Ala Leu Lys Leu 
        595                 600                 605             


Pro Pro Ser Gln Pro Pro Arg Leu Leu Lys Asn Lys Ala Leu Leu Cys 
    610                 615                 620                 


Lys Pro Ile Thr Gln Thr Lys Ala Thr Ser Cys Lys Pro His Thr Gln 
625                 630                 635                 640 


Asn Lys Glu Cys Gln Thr Glu Asp Thr Pro Ser Gln Pro Gln Ile Ile 
                645                 650                 655     


Val Val Pro Val Pro Val Pro Val Phe Val Pro Ile Pro Leu His Leu 
            660                 665                 670         


Tyr Thr Gln Tyr Ala Pro Val Pro Phe Gly Ile Pro Val Pro Met Pro 
        675                 680                 685             


Val Pro Met Leu Ile Pro Ser Ser Met Asp Ser Glu Asp Lys Val Thr 
    690                 695                 700                 


Glu Ser Ile Glu Asp Ile Lys Glu Lys Leu Pro Thr His Pro Phe Glu 
705                 710                 715                 720 


Ala Asp Leu Leu Glu Met Ala Glu Met Ile Ala Glu Asp Glu Glu Lys 
                725                 730                 735     


Lys Thr Leu Ser Gln Gly Glu Ser Gln Thr Ser Glu His Glu Leu Phe 
            740                 745                 750         


Leu Asp Thr Lys Ile Phe Glu Lys Asp Gln Gly Ser Thr Tyr Ser Gly 
        755                 760                 765             


Asp Leu Glu Ser Glu Ala Val Ser Thr Pro His Ser Trp Glu Glu Glu 
    770                 775                 780                 


Leu Asn His Tyr Ala Leu Lys Ser Asn Ala Val Gln Glu Ala Asp Ser 
785                 790                 795                 800 


Glu Leu Lys Gln Phe Ser Lys Gly Glu Thr Glu Gln Asp Leu Glu Ala 
                805                 810                 815     


Asp Phe Pro Ser Asp Ser Phe Asp Pro Leu Asn Lys Gly Gln Gly Ile 
            820                 825                 830         


Gln Ala Arg Ser Arg Thr Arg Arg Arg His Arg Asp Gly Phe Pro Gln 
        835                 840                 845             


Pro Arg Arg Arg Gly Arg Lys Lys Ser Ile Val Ala Val Glu Pro Arg 
    850                 855                 860                 


Ser Leu Ile Gln Gly Ala Phe Gln Gly Cys Ser Val Ser Gly Met Thr 
865                 870                 875                 880 


Leu Lys Tyr Met Tyr Gly Val Asn Ala Trp Lys Asn Trp Val Gln Trp 
                885                 890                 895     


Lys Asn Ala Lys Glu Glu Gln Gly Asp Leu Lys Cys Gly Gly Val Glu 
            900                 905                 910         


Gln Ala Ser Ser Ser Pro Arg Ser Asp Pro Leu Gly Ser Thr Gln Asp 
        915                 920                 925             


His Ala Leu Ser Gln Glu Ser Ser Glu Pro Gly Cys Arg Val Arg Ser 
    930                 935                 940                 


Ile Lys Leu Lys Glu Asp Ile Leu Ser Cys Thr Phe Ala Glu Leu Ser 
945                 950                 955                 960 


Leu Gly Leu Cys Gln Phe Ile Gln Glu Val Arg Arg Pro Asn Gly Glu 
                965                 970                 975     


Lys Tyr Asp Pro Asp Ser Ile Leu Tyr Leu Cys Leu Gly Ile Gln Gln 
            980                 985                 990         


Tyr Leu Phe Glu Asn Gly Arg Ile  Asp Asn Ile Phe Thr  Glu Pro Tyr 
        995                 1000                 1005             


Ser Arg  Phe Met Ile Glu Leu  Thr Lys Leu Leu Lys  Ile Trp Glu 
    1010                 1015                 1020             


Pro Thr  Ile Leu Pro Asn Gly  Tyr Met Phe Ser Arg  Ile Glu Glu 
    1025                 1030                 1035             


Glu His  Leu Trp Glu Cys Lys  Gln Leu Gly Ala Tyr  Ser Pro Ile 
    1040                 1045                 1050             


Val Leu  Leu Asn Thr Leu Leu  Phe Phe Asn Thr Lys  Tyr Phe Gln 
    1055                 1060                 1065             


Leu Lys  Asn Val Thr Glu His  Leu Lys Leu Ser Phe  Ala His Val 
    1070                 1075                 1080             


Met Arg  Arg Thr Arg Thr Leu  Lys Tyr Ser Thr Lys  Met Thr Tyr 
    1085                 1090                 1095             


Leu Arg  Phe Phe Pro Pro Leu  Gln Lys Gln Glu Ser  Glu Pro Asp 
    1100                 1105                 1110             


Lys Leu  Thr Val Gly Lys Arg  Lys Arg Asn Glu Asp  Asp Glu Val 
    1115                 1120                 1125             


Pro Val  Gly Val Glu Met Ala  Glu Asn Thr Asp Asn  Pro Leu Arg 
    1130                 1135                 1140             


Cys Pro  Val Arg Leu Tyr Glu  Phe Tyr Leu Ser Lys  Cys Ser Glu 
    1145                 1150                 1155             


Ser Val  Lys Gln Arg Asn Asp  Val Phe Tyr Leu Gln  Pro Glu Arg 
    1160                 1165                 1170             


Ser Cys  Val Pro Asn Ser Pro  Met Trp Tyr Ser Thr  Phe Pro Ile 
    1175                 1180                 1185             


Asp Pro  Gly Thr Leu Asp Thr  Met Leu Thr Arg Ile  Leu Met Val 
    1190                 1195                 1200             


Arg Glu  Val His Glu Glu Leu  Ala Lys Ala Lys Ser  Glu Asp Ser 
    1205                 1210                 1215             


Asp Val  Glu Leu Ser Asp 
    1220                 


<210>  5844
<211>  461
<212>  DNA
<213>  Homosapiens

<400>  5844
cagaaaactc cagaaacaac caatactcat tggcatacat taacggtctg cagtcagctc     60

tcttagtctc tgtgatggct attgcaaact tctgctggat tcctttagcc ttgactatca    120

tcagtatgaa ttgaagaaac aagattgtcc tttgaactaa aatcctgttc atcctcattg    180

tcactaccaa cgactggaat tcctgcaaga tccccagagt tcaaaaaata atcatcttca    240

tccagcaatg aattttcaga tcctgtttga ttcggcattc cataagacat gctgtcaagg    300

gtaggagtta agttgtggtc tatatcttca gacatttctg tatccatgat accaccacct    360

taaaaagtaa aatactgttt agacaaatga tagtgctaaa gatgaccaca atgataaggt    420

cagtctggta tttaaccaaa taaatatttt ttcaaacaaa a                        461


<210>  5845
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  5845

Arg Ser Ala Val Ser Ser Leu Ser Leu Cys Asp Gly Tyr Cys Lys Leu 
1               5                   10                  15      


Leu Leu Asp Ser Phe Ser Leu Asp Tyr His Gln Tyr Glu Leu Lys Lys 
            20                  25                  30          


Gln Asp Cys Pro Leu Asn 
        35              


<210>  5846
<211>  559
<212>  DNA
<213>  Homosapiens

<400>  5846
taccctgtcg gtcatttcaa aaaaatgaag cataaacgat gtgcatatca gtaacttcca     60

gaaaaacttc taaccatatt taaatttctt ttaaacatct cttatctaac tgaactagga    120

ggaggagtat ctttttctcc tctccgggca gacaaagtgc agcatctgtg tgaggaacta    180

taaacattac cgcctaaagt aataaatgaa tcatggtttg agtagcctga tagagtgttt    240

cagaacaaga gcattattcc tctttttctg acttaaactg tttctaacaa tcataaaatt    300

agtcaaagtt attgtgtatt cctcaaatat atcaggatga ccttattaca gtcataagat    360

catacccctt ttttgttatt aaacattcca atggacacaa tgtggtagtt cagagacatt    420

gagaaaataa aaatataggc caagcgcggt agctcacacc tgtaatccca gcatcaggag    480

gccgaggcag gagaatggca tgaacccggg aggcggagct tgcagtgagc cgagatcaca    540

ccactgcact ccagcctgg                                                 559


<210>  5847
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  5847

Leu Pro Glu Lys Leu Leu Thr Ile Phe Lys Phe Leu Leu Asn Ile Ser 
1               5                   10                  15      


Tyr Leu Thr Glu Leu Gly Gly Gly Val Ser Phe Ser Pro Leu Arg Ala 
            20                  25                  30          


Asp Lys Val Gln His Leu Cys Glu Glu Leu 
        35                  40          


<210>  5848
<211>  315
<212>  DNA
<213>  Homosapiens

<400>  5848
ggcagatcac ctgaggtcaa gagatcaaga ccatcctggc caatacggtg aaaccccatc     60

tctactaaaa atacaaaaaa attagctggg ccttaaatag gagttttcca gaaagttaag    120

gagataagaa ttgggagcag catggatcaa ggaaatggaa gtataaaatt aggtattttt    180

tcactgctct cactatgctt agagtccaat tagattacat cttattgtgg tagtggatta    240

tatcttatga cagaatgaga agaaacaatc tcattcaagt tagtgaaaat tcagaaatgg    300

tacagacaat ctggg                                                     315


<210>  5849
<211>  2989
<212>  DNA
<213>  Homosapiens

<400>  5849
tgtgtcagag agggttgttt ccttgaaggg ggaaaccctt agcaaggtgc ctcatgatat     60

ctgactccat attcactcac atgctgaact gggtgttaga acaccaacct tacagctctc    120

tgcgatgcaa gaaggagact acacttacca gctcacagtg actgacacaa taggacagca    180

ggccactgct caagtgactg ttattgtgca acctgaaaac aataagcctc ctcaggcaga    240

tgcaggccca gataaagagc tgacccttcc tgtggatagc acaaccctgg atggcagcaa    300

gagctcagat gatcagaaaa ttatctcata tctctgggaa aaaacacagg gacctgatgg    360

ggtgcagctc gagaatgcta acagcagtgt tgctactgtg actgggctgc aagtggggac    420

ctatgtgttc accttgactg tcaaagatga gaggaacctg caaagccaga gctctgtgaa    480

tgtcattgtc aaagaagaaa taaacaaacc acctatagcc aagataactg ggaatgtggt    540

gattacccta cccacgagca cagcagagct ggatggctct aagtcctcag atgacaaggg    600

aatagtcagc tacctctgga ctcgagatga ggggagccca gcagcagggg aggtgttaaa    660

tcactctgac catcacccta tcctttttct ttcaaacctg gttgagggaa cctacacttt    720

tcacctgaaa gtgaccgatg caaagggtga gagtgacaca gaccggacca ctgtggaggt    780

gaaacctgat cccaggaaaa acaacctggt ggagatcatc ttggatatca acgtcagtca    840

gctaactgag aggctgaagg ggatgttcat ccgccagatt ggggtcctcc tgggggtgct    900

ggattccgac atcattgtgc aaaagattca gccgtacacg gagcagagca ccaaaatggt    960

attttttgtt caaaacgagc ctccccacca gatcttcaaa ggccatgagg tggcagcgat   1020

gctcaagagt gagctgcgga agcaaaaggc agactttttg atattcagag ccttggaagt   1080

caacactgtc acatgtcagc tgaactgttc cgaccatggc cactgtgact cgttcaccaa   1140

acgctgtatc tgtgaccctt tttggatgga gaatttcatc aaggtgcagc tgagggatgg   1200

agacagcaac tgtgagtgga gcgtgttata tgttatcatt gctacctttg tcattgttgt   1260

tgccttggga atcctgtctt ggactgtgat ctgttgttgt aagaggcaaa aaggaaaacc   1320

caagaggaaa agcaagtaca agatcctgga tgccacggat caggaaagcc tggagctgaa   1380

gccaacctcc cgagcaggca tcaaacagaa aggccttttg ctaagtagca gcctgatgca   1440

ctccgagtca gagctggaca gcgatgatgc catctttaca tggccagacc gagagaaggg   1500

caaactcctg catggtcaga atggctctgt acccaacggg cagacccctc tgaaggccag   1560

gagcccgcgg gaggagatcc tgtagccacc tggtctgtct cctcagggca gggcccagca   1620

cactgcccgg ccagtcctcc tacctcccga gtctgcgggc agctgctgtc ccagcatctg   1680

ctggtcattt cgccctgaca gtcccaacca gaacccctgg gacttgaatc cagagacgtc   1740

ctccaggaac ccctcaacga agctgtgaat gaagaggttt cctctttaaa cctgtctggt   1800

gggcccccag atatcctcac ctcagggcct cctttttttg caaactcctc ccctcccccg   1860

agggcagacc cagccagctg ctaagctctg cagctcccca gtggacagtg tcattgtgcc   1920

cagagtgctg caaggtgagg cctgctgtgc tgcccgcaca cctgagtgca aaaccaagca   1980

ctgtgggcat ggtgtttccc tctctggggt agagtacgcc ctctcgctgg gcaaagagga   2040

agtggcaccc ctcccctcac cacagatgct gagatggtag catagaaatg atggccgggc   2100

gcggtggctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg gatcatgagg   2160

tcaggagatc aagaccaccc tggctaacac ggtgaaaccc catctctact aaaaataaaa   2220

aaaaaaatta gccgggtttg gtggcgtatg cctgtaatcc cagctactcg ggaggctgag   2280

gcaggagaat tgcttaaacc tgggaggtgg aggctgcagt gagccaagat cgtgccactg   2340

cactccagcc tgagtgacag agcaagactc cgtcaaaaaa aaaaaaaaaa aaaaagaaat   2400

gatatctggc ccccccttaa cactggagcc ccactccctt ctcccatccg gcccgagatt   2460

agggaggatt gactgtgtca gggatggcgg gtggcctctc tcgctgccag ggcccttgtc   2520

agagcagcca ggctggacag acggcctccc tcctctccat ctgaccggca cctgctgctt   2580

cggggcttag gccaccgctc cctgtcccca gaggagatag ccccagatgg actggaatgt   2640

tgtggcatga gagcgcatgt gtgcgatggc cccgctgtgg tcccctctct gtccctccat   2700

ctgtatgtgt tctgtgtccc ttgcatgtgt gcgtgttaga gtgagcgcgt atgcatcaac   2760

tcattgggct cttggctgct cacaaggcaa atttgacttg gaaagacttt catctccttg   2820

gaaccaagac ttcctgagtc cccctcaccc tggccctgtt ccaccatggt tatctgggta   2880

ttggggaatg gaaactttgg gggagtgact ttttaaagag acacttataa tttctactac   2940

tgcactactg tccattgtgg gatgattaaa catggtattt aactgtgca               2989


<210>  5850
<211>  486
<212>  PRT
<213>  Homosapiens

<400>  5850

Met Gln Glu Gly Asp Tyr Thr Tyr Gln Leu Thr Val Thr Asp Thr Ile 
1               5                   10                  15      


Gly Gln Gln Ala Thr Ala Gln Val Thr Val Ile Val Gln Pro Glu Asn 
            20                  25                  30          


Asn Lys Pro Pro Gln Ala Asp Ala Gly Pro Asp Lys Glu Leu Thr Leu 
        35                  40                  45              


Pro Val Asp Ser Thr Thr Leu Asp Gly Ser Lys Ser Ser Asp Asp Gln 
    50                  55                  60                  


Lys Ile Ile Ser Tyr Leu Trp Glu Lys Thr Gln Gly Pro Asp Gly Val 
65                  70                  75                  80  


Gln Leu Glu Asn Ala Asn Ser Ser Val Ala Thr Val Thr Gly Leu Gln 
                85                  90                  95      


Val Gly Thr Tyr Val Phe Thr Leu Thr Val Lys Asp Glu Arg Asn Leu 
            100                 105                 110         


Gln Ser Gln Ser Ser Val Asn Val Ile Val Lys Glu Glu Ile Asn Lys 
        115                 120                 125             


Pro Pro Ile Ala Lys Ile Thr Gly Asn Val Val Ile Thr Leu Pro Thr 
    130                 135                 140                 


Ser Thr Ala Glu Leu Asp Gly Ser Lys Ser Ser Asp Asp Lys Gly Ile 
145                 150                 155                 160 


Val Ser Tyr Leu Trp Thr Arg Asp Glu Gly Ser Pro Ala Ala Gly Glu 
                165                 170                 175     


Val Leu Asn His Ser Asp His His Pro Ile Leu Phe Leu Ser Asn Leu 
            180                 185                 190         


Val Glu Gly Thr Tyr Thr Phe His Leu Lys Val Thr Asp Ala Lys Gly 
        195                 200                 205             


Glu Ser Asp Thr Asp Arg Thr Thr Val Glu Val Lys Pro Asp Pro Arg 
    210                 215                 220                 


Lys Asn Asn Leu Val Glu Ile Ile Leu Asp Ile Asn Val Ser Gln Leu 
225                 230                 235                 240 


Thr Glu Arg Leu Lys Gly Met Phe Ile Arg Gln Ile Gly Val Leu Leu 
                245                 250                 255     


Gly Val Leu Asp Ser Asp Ile Ile Val Gln Lys Ile Gln Pro Tyr Thr 
            260                 265                 270         


Glu Gln Ser Thr Lys Met Val Phe Phe Val Gln Asn Glu Pro Pro His 
        275                 280                 285             


Gln Ile Phe Lys Gly His Glu Val Ala Ala Met Leu Lys Ser Glu Leu 
    290                 295                 300                 


Arg Lys Gln Lys Ala Asp Phe Leu Ile Phe Arg Ala Leu Glu Val Asn 
305                 310                 315                 320 


Thr Val Thr Cys Gln Leu Asn Cys Ser Asp His Gly His Cys Asp Ser 
                325                 330                 335     


Phe Thr Lys Arg Cys Ile Cys Asp Pro Phe Trp Met Glu Asn Phe Ile 
            340                 345                 350         


Lys Val Gln Leu Arg Asp Gly Asp Ser Asn Cys Glu Trp Ser Val Leu 
        355                 360                 365             


Tyr Val Ile Ile Ala Thr Phe Val Ile Val Val Ala Leu Gly Ile Leu 
    370                 375                 380                 


Ser Trp Thr Val Ile Cys Cys Cys Lys Arg Gln Lys Gly Lys Pro Lys 
385                 390                 395                 400 


Arg Lys Ser Lys Tyr Lys Ile Leu Asp Ala Thr Asp Gln Glu Ser Leu 
                405                 410                 415     


Glu Leu Lys Pro Thr Ser Arg Ala Gly Ile Lys Gln Lys Gly Leu Leu 
            420                 425                 430         


Leu Ser Ser Ser Leu Met His Ser Glu Ser Glu Leu Asp Ser Asp Asp 
        435                 440                 445             


Ala Ile Phe Thr Trp Pro Asp Arg Glu Lys Gly Lys Leu Leu His Gly 
    450                 455                 460                 


Gln Asn Gly Ser Val Pro Asn Gly Gln Thr Pro Leu Lys Ala Arg Ser 
465                 470                 475                 480 


Pro Arg Glu Glu Ile Leu 
                485     


<210>  5851
<211>  4779
<212>  DNA
<213>  Homosapiens

<400>  5851
gtttccggcc gccgtcgctg tccagggagg ctgaggcgag aggtagctgt ccgggtgggg     60

agcccgcact accttcttcc tcttcctcct cctcctccgg gtgaggggag cgaaggttgg    120

gggtccccga gcccatggac caggaggagg cggaggccgc cgagagccgg ggccccgcta    180

tgtggccctg agccccgtgt actggttctg cctgtctgga gggccatgga gaagaggctg    240

ggagtcaagc caaatcctgc ttcctggatt ttatcaggat attattggca gacatctgcg    300

aagtggttga gaagcctgta cctgttttat acttgctttt gcttcagcgt tctgtggttg    360

tcaacagatg ccagtgagag caggtgccag caggggaaga cacaatttgg agttggcctg    420

agatctgggg gagaaaatca cctctggctt cttgaaggaa ccccctctct ccagtcatgt    480

tgggctgcct gctgccagga ctctgcctgc catgtctttt ggtggctaga agggatgtgc    540

attcaggcag actgcagcag gccccagagc tgccgggctt ttaggacaca ctcctccaat    600

tccatgctgg tgtttttaaa aaaattccaa actgcagatg atttgggctt tctacctgaa    660

gatgatgtac cacatcttct ggggctaggt tggaactggg catcttggag gcagagccca    720

cccagagctg cactcagacc tgctgtatct tccagtgacc agcagagctt aatcaggaag    780

cttcagaaga gaggtagtcc cagtgacgta gttacaccta tagtgacaca gcattctaaa    840

gtgaatgact ccaacgaatt aggtggtctg actaccagtg gctctgcaga ggtccacaag    900

gcgattacaa tttccagtcc cctaaccaca gacctgactg cagagctgtc tggtgggcca    960

aagaatgtat cagtgcaacc tgaaatatca gagggtcttg ctactacgcc cagcactcaa   1020

caagtaaaaa gttctgagaa aacccagatt gctgtccccc agccagtggc tccctcctac   1080

agttatgcta cccctacccc ccaggcctct ttccagagca cctcagcacc atacccagtt   1140

ataaaggaac tggtggtatc tgctggagag agtgtccaga taaccctgcc taagaatgaa   1200

gttcaattaa atgcatatgt tctccaagaa ccacctaaag gagaaaccta cacctacgac   1260

tggcagctga ttactcatcc tagagactac agtggagaaa tggaagggaa acattcccag   1320

atcctcaaac tatcgaagct cactccaggc ctgtatgaat tcaaagtgat tgtagagggt   1380

caaaatgccc atggggaagg ctatgtgaac gtgacagtca agccagagcc ccgtaagaat   1440

cggcccccca ttgctattgt gtcacctcag ttccaggaga tctctttgcc aaccacttct   1500

acagtcattg atggcagtca aagcactgat gatgataaaa tcgttcagta ccattgggaa   1560

gaacttaagg ggcctctaag agaagagaag atttctgaag atacagccat attaaaacta   1620

agtaaactcg tccctgggaa ctacactttc agcttgactg tagtagactc tgatggagct   1680

accaactcta ctactgcaaa cctgacagtg aacaaagctg tggattaccc ccctgtggcc   1740

aacgcaggcc ccaaccaagt gatcaccctg ccccaaaact ccatcaccct ctttgggaac   1800

cagagcactg atgatcatgg catcaccagc tatgagtggt cactcagccc aagcagcaaa   1860

gggaaagtgg tggagatgca gggtgttaga acaccaacct tacagctctc tgcgatgcaa   1920

gaaggagact acacttacca gctcacagtg actgacacaa taggacagca ggccactgct   1980

caagtgactg ttattgtgca acctgaaaac aataagcctc ctcaggcaga tgcaggccca   2040

gataaagagc tgacccttcc tgtggatagc acaaccctgg atggcagcaa gagctcagat   2100

gatcagaaaa ttatctcata tctctgggaa aaaacacagg gacctgatgg ggtgcagctc   2160

gagaatgcta acagcagtgt tgctactgtg actgggctgc aagtggggac ctatgtgttc   2220

accttgactg tcaaagatga gaggaacctg caaagccaga gctctgtgaa tgtcattgtc   2280

aaagaagaaa taaacaaacc acctatagcc aagataactg ggaatgtggt gattacccta   2340

cccacgagca cagcagagct ggatggctct aagtcctcag atgacaaggg aatagtcagc   2400

tacctctgga ctcgagatga ggggagccca gcagcagggg aggtgttaaa tcactctgac   2460

catcacccta tcctttttct ttcaaacctg gttgagggaa cctacacttt tcacctgaaa   2520

gtgaccgatg caaagggtga gagtgacaca gaccggacca ctgtggaggt gaaacctgat   2580

cccaggaaaa acaacctggt ggagatcatc ttggatatca acgtcagtca gctaactgag   2640

aggctgaagg ggatgttcat ccgccagatt ggggtcctcc tgggggtgct ggattccgac   2700

atcattgtgc aaaagattca gccgtacacg gagcagagca ccaaaatggt attttttgtt   2760

caaaacgagc ctccccacca gatcttcaaa ggccatgagg tggcagcgat gctcaagagt   2820

gagctgcgga agcaaaaggc agactttttg atattcagag ccttggaagt caacactgtc   2880

acatgtcagc tgaactgttc cgaccatggc cactgtgact cgttcaccaa acgctgtatc   2940

tgtgaccctt tttggatgga gaatttcatc aaggtgcagc tgagggatgg agacagcaac   3000

tgtgagtgga gcgtgttata tgttatcatt gctacctttg tcattgttgt tgccttggga   3060

atcctgtctt ggactgtgat ctgttgttgt aagaggcaaa aaggaaaacc caagaggaaa   3120

agcaagtaca agatcctgga tgccacggat caggaaagcc tggagctgaa gccaacctcc   3180

cgagcaggca tcaaacagaa aggccttttg ctaagtagca gcctgatgca ctccgagtca   3240

gagctggaca gcgatgatgc catctttaca tggccagacc gagagaaggg caaactcctg   3300

catggtcaga atggctctgt acccaacggg cagacccctc tgaaggccag gagcccgcgg   3360

gaggagatcc tgtagccacc tggtctgtct cctcagggca gggcccagca cactgcccgg   3420

ccagtcctcc tacctcccga gtctgcgggc agctgctgtc ccagcatctg ctggtcattt   3480

cgccctgaca gtcccaacca gaacccctgg gacttgaatc cagagacgtc ctccaggaac   3540

ccctcaacga agctgtgaat gaagaggttt cctctttaaa cctgtctggt gggcccccag   3600

atatcctcac ctcagggcct cctttttttg caaactcctc ccctcccccg agggcagacc   3660

cagccagctg ctaagctctg cagctcccca gtggacagtg tcattgtgcc cagagtgctg   3720

caaggtgagg cctgctgtgc tgcccgcaca cctgagtgca aaaccaagca ctgtgggcat   3780

ggtgtttccc tctctggggt agagtacgcc ctctcgctgg gcaaagagga agtggcaccc   3840

ctcccctcac cacagatgct gagatggtag catagaaatg atggccgggc gcggtggctc   3900

acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg gatcatgagg tcaggagatc   3960

aagaccaccc tggctaacac ggtgaaaccc catctctact aaaaataaaa aaaaaaatta   4020

gccgggtttg gtggcgtatg cctgtaatcc cagctactcg ggaggctgag gcaggagaat   4080

tgcttaaacc tgggaggtgg aggctgcagt gagccaagat cgtgccactg cactccagcc   4140

tgagtgacag agcaagactc cgtcaaaaaa aaaaaaaaaa aaaaagaaat gatatctggc   4200

ccccccttaa cactggagcc ccactccctt ctcccatccg gcccgagatt agggaggatt   4260

gactgtgtca gggatggcgg gtggcctctc tcgctgccag ggcccttgtc agagcagcca   4320

ggctggacag acggcctccc tcctctccat ctgaccggca cctgctgctt cggggcttag   4380

gccaccgctc cctgtcccca gaggagatag ccccagatgg actggaatgt tgtggcatga   4440

gagcgcatgt gtgcgatggc cccgctgtgg tcccctctct gtccctccat ctgtatgtgt   4500

tctgtgtccc ttgcatgtgt gcgtgttaga gtgagcgcgt atgcatcaac tcattgggct   4560

cttggctgct cacaaggcaa atttgacttg gaaagacttt catctccttg gaaccaagac   4620

ttcctgagtc cccctcaccc tggccctgtt ccaccatggt tatctgggta ttggggaatg   4680

gaaactttgg gggagtgact ttttaaagag acacttataa tttctactac tgcactactg   4740

tccattgtgg gatgattaaa catggtattt aactgtgca                          4779


<210>  5852
<211>  1049
<212>  PRT
<213>  Homosapiens

<400>  5852

Met Glu Lys Arg Leu Gly Val Lys Pro Asn Pro Ala Ser Trp Ile Leu 
1               5                   10                  15      


Ser Gly Tyr Tyr Trp Gln Thr Ser Ala Lys Trp Leu Arg Ser Leu Tyr 
            20                  25                  30          


Leu Phe Tyr Thr Cys Phe Cys Phe Ser Val Leu Trp Leu Ser Thr Asp 
        35                  40                  45              


Ala Ser Glu Ser Arg Cys Gln Gln Gly Lys Thr Gln Phe Gly Val Gly 
    50                  55                  60                  


Leu Arg Ser Gly Gly Glu Asn His Leu Trp Leu Leu Glu Gly Thr Pro 
65                  70                  75                  80  


Ser Leu Gln Ser Cys Trp Ala Ala Cys Cys Gln Asp Ser Ala Cys His 
                85                  90                  95      


Val Phe Trp Trp Leu Glu Gly Met Cys Ile Gln Ala Asp Cys Ser Arg 
            100                 105                 110         


Pro Gln Ser Cys Arg Ala Phe Arg Thr His Ser Ser Asn Ser Met Leu 
        115                 120                 125             


Val Phe Leu Lys Lys Phe Gln Thr Ala Asp Asp Leu Gly Phe Leu Pro 
    130                 135                 140                 


Glu Asp Asp Val Pro His Leu Leu Gly Leu Gly Trp Asn Trp Ala Ser 
145                 150                 155                 160 


Trp Arg Gln Ser Pro Pro Arg Ala Ala Leu Arg Pro Ala Val Ser Ser 
                165                 170                 175     


Ser Asp Gln Gln Ser Leu Ile Arg Lys Leu Gln Lys Arg Gly Ser Pro 
            180                 185                 190         


Ser Asp Val Val Thr Pro Ile Val Thr Gln His Ser Lys Val Asn Asp 
        195                 200                 205             


Ser Asn Glu Leu Gly Gly Leu Thr Thr Ser Gly Ser Ala Glu Val His 
    210                 215                 220                 


Lys Ala Ile Thr Ile Ser Ser Pro Leu Thr Thr Asp Leu Thr Ala Glu 
225                 230                 235                 240 


Leu Ser Gly Gly Pro Lys Asn Val Ser Val Gln Pro Glu Ile Ser Glu 
                245                 250                 255     


Gly Leu Ala Thr Thr Pro Ser Thr Gln Gln Val Lys Ser Ser Glu Lys 
            260                 265                 270         


Thr Gln Ile Ala Val Pro Gln Pro Val Ala Pro Ser Tyr Ser Tyr Ala 
        275                 280                 285             


Thr Pro Thr Pro Gln Ala Ser Phe Gln Ser Thr Ser Ala Pro Tyr Pro 
    290                 295                 300                 


Val Ile Lys Glu Leu Val Val Ser Ala Gly Glu Ser Val Gln Ile Thr 
305                 310                 315                 320 


Leu Pro Lys Asn Glu Val Gln Leu Asn Ala Tyr Val Leu Gln Glu Pro 
                325                 330                 335     


Pro Lys Gly Glu Thr Tyr Thr Tyr Asp Trp Gln Leu Ile Thr His Pro 
            340                 345                 350         


Arg Asp Tyr Ser Gly Glu Met Glu Gly Lys His Ser Gln Ile Leu Lys 
        355                 360                 365             


Leu Ser Lys Leu Thr Pro Gly Leu Tyr Glu Phe Lys Val Ile Val Glu 
    370                 375                 380                 


Gly Gln Asn Ala His Gly Glu Gly Tyr Val Asn Val Thr Val Lys Pro 
385                 390                 395                 400 


Glu Pro Arg Lys Asn Arg Pro Pro Ile Ala Ile Val Ser Pro Gln Phe 
                405                 410                 415     


Gln Glu Ile Ser Leu Pro Thr Thr Ser Thr Val Ile Asp Gly Ser Gln 
            420                 425                 430         


Ser Thr Asp Asp Asp Lys Ile Val Gln Tyr His Trp Glu Glu Leu Lys 
        435                 440                 445             


Gly Pro Leu Arg Glu Glu Lys Ile Ser Glu Asp Thr Ala Ile Leu Lys 
    450                 455                 460                 


Leu Ser Lys Leu Val Pro Gly Asn Tyr Thr Phe Ser Leu Thr Val Val 
465                 470                 475                 480 


Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Asn Leu Thr Val Asn 
                485                 490                 495     


Lys Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn Gln Val 
            500                 505                 510         


Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Phe Gly Asn Gln Ser Thr 
        515                 520                 525             


Asp Asp His Gly Ile Thr Ser Tyr Glu Trp Ser Leu Ser Pro Ser Ser 
    530                 535                 540                 


Lys Gly Lys Val Val Glu Met Gln Gly Val Arg Thr Pro Thr Leu Gln 
545                 550                 555                 560 


Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Tyr Gln Leu Thr Val Thr 
                565                 570                 575     


Asp Thr Ile Gly Gln Gln Ala Thr Ala Gln Val Thr Val Ile Val Gln 
            580                 585                 590         


Pro Glu Asn Asn Lys Pro Pro Gln Ala Asp Ala Gly Pro Asp Lys Glu 
        595                 600                 605             


Leu Thr Leu Pro Val Asp Ser Thr Thr Leu Asp Gly Ser Lys Ser Ser 
    610                 615                 620                 


Asp Asp Gln Lys Ile Ile Ser Tyr Leu Trp Glu Lys Thr Gln Gly Pro 
625                 630                 635                 640 


Asp Gly Val Gln Leu Glu Asn Ala Asn Ser Ser Val Ala Thr Val Thr 
                645                 650                 655     


Gly Leu Gln Val Gly Thr Tyr Val Phe Thr Leu Thr Val Lys Asp Glu 
            660                 665                 670         


Arg Asn Leu Gln Ser Gln Ser Ser Val Asn Val Ile Val Lys Glu Glu 
        675                 680                 685             


Ile Asn Lys Pro Pro Ile Ala Lys Ile Thr Gly Asn Val Val Ile Thr 
    690                 695                 700                 


Leu Pro Thr Ser Thr Ala Glu Leu Asp Gly Ser Lys Ser Ser Asp Asp 
705                 710                 715                 720 


Lys Gly Ile Val Ser Tyr Leu Trp Thr Arg Asp Glu Gly Ser Pro Ala 
                725                 730                 735     


Ala Gly Glu Val Leu Asn His Ser Asp His His Pro Ile Leu Phe Leu 
            740                 745                 750         


Ser Asn Leu Val Glu Gly Thr Tyr Thr Phe His Leu Lys Val Thr Asp 
        755                 760                 765             


Ala Lys Gly Glu Ser Asp Thr Asp Arg Thr Thr Val Glu Val Lys Pro 
    770                 775                 780                 


Asp Pro Arg Lys Asn Asn Leu Val Glu Ile Ile Leu Asp Ile Asn Val 
785                 790                 795                 800 


Ser Gln Leu Thr Glu Arg Leu Lys Gly Met Phe Ile Arg Gln Ile Gly 
                805                 810                 815     


Val Leu Leu Gly Val Leu Asp Ser Asp Ile Ile Val Gln Lys Ile Gln 
            820                 825                 830         


Pro Tyr Thr Glu Gln Ser Thr Lys Met Val Phe Phe Val Gln Asn Glu 
        835                 840                 845             


Pro Pro His Gln Ile Phe Lys Gly His Glu Val Ala Ala Met Leu Lys 
    850                 855                 860                 


Ser Glu Leu Arg Lys Gln Lys Ala Asp Phe Leu Ile Phe Arg Ala Leu 
865                 870                 875                 880 


Glu Val Asn Thr Val Thr Cys Gln Leu Asn Cys Ser Asp His Gly His 
                885                 890                 895     


Cys Asp Ser Phe Thr Lys Arg Cys Ile Cys Asp Pro Phe Trp Met Glu 
            900                 905                 910         


Asn Phe Ile Lys Val Gln Leu Arg Asp Gly Asp Ser Asn Cys Glu Trp 
        915                 920                 925             


Ser Val Leu Tyr Val Ile Ile Ala Thr Phe Val Ile Val Val Ala Leu 
    930                 935                 940                 


Gly Ile Leu Ser Trp Thr Val Ile Cys Cys Cys Lys Arg Gln Lys Gly 
945                 950                 955                 960 


Lys Pro Lys Arg Lys Ser Lys Tyr Lys Ile Leu Asp Ala Thr Asp Gln 
                965                 970                 975     


Glu Ser Leu Glu Leu Lys Pro Thr Ser Arg Ala Gly Ile Lys Gln Lys 
            980                 985                 990         


Gly Leu Leu Leu Ser Ser Ser Leu  Met His Ser Glu Ser  Glu Leu Asp 
        995                 1000                 1005             


Ser Asp  Asp Ala Ile Phe Thr  Trp Pro Asp Arg Glu  Lys Gly Lys 
    1010                 1015                 1020             


Leu Leu  His Gly Gln Asn Gly  Ser Val Pro Asn Gly  Gln Thr Pro 
    1025                 1030                 1035             


Leu Lys  Ala Arg Ser Pro Arg  Glu Glu Ile Leu 
    1040                 1045                 


<210>  5853
<211>  4164
<212>  DNA
<213>  Homosapiens

<400>  5853
gtttccggcc gccgtcgctg tccagggagg ctgaggcgag aggtagctgt ccgggtgggg     60

agcccgcact accttcttcc tcttcctcct cctcctccgg gtgaggggag cgaaggttgg    120

gggtccccga gcccatggac caggaggagg cggaggccgc cgagagccgg ggccccgcta    180

tgtggccctg agccccgtgt actggttctg cctgtctgga gggccatgga gaagaggctg    240

ggagtcaagc caaatcctgc ttcctggatt ttatcaggat attattggca gacatctgcg    300

aagtggttga gaagcctgta cctgttttat acttgctttt gcttcagcgt tctgtggttg    360

tcaacagatg ccagtgagag caggtgccag caggggaaga cacaatttgg agttggcctg    420

agatctgggg gagaaaatca cctctggctt cttgaaggaa ccccctctct ccagtcatgt    480

tgggctgcct gctgccagga ctctgcctgc catgtctttt ggtggctaga agggatgtgc    540

attcaggcag actgcagcag gccccagagc tgccgggctt ttaggacaca ctcctccaat    600

tccatgctgg tgtttttaaa aaaattccaa actgcagatg atttgggctt tctacctgaa    660

gatgatgtac cacatcttct ggggctaggt tggaactggg catcttggag gcagagccca    720

cccagagctg cactcagacc tgctgtatct tccagtgacc agcagagctt aatcaggaag    780

cttcagaaga gaggtagtcc cagtgacgta gttacaccta tagtgacaca gcattctaaa    840

gtgaatgact ccaacgaatt aggtggtctg actaccagtg gctctgcaga ggtccacaag    900

gcgattacaa tttccagtcc cctaaccaca gacctgactg cagagctgtc tggtgggcca    960

aagaatgtat cagtgcaacc tgaaatatca gagggtcttg ctactacgcc cagcactcaa   1020

caagtaaaaa gttctgagaa aacccagatt gctgtccccc agccagtggc tccctcctac   1080

agttatgcta cccctacccc ccaggcctct ttccagagca cctcagcacc atacccagtt   1140

ataaaggaac tggtggtatc tgctggagag agtgtccaga taaccctgcc taagaatgaa   1200

gttcaattaa atgcatatgt tctccaagaa ccacctaaag gagaaaccta cacctacgac   1260

tggcagctga ttactcatcc tagagactac agtggagaaa tggaagggaa acattcccag   1320

atcctcaaac tatcgaagct cactccaggc ctgtatgaat tcaaagtgat tgtagagggt   1380

caaaatgccc atggggaagg ctatgtgaac gtgacagtca agccagagcc ccgtaagaat   1440

cggcccccca ttgctattgt gtcacctcag ttccaggaga tctctttgcc aaccacttct   1500

acagtcattg atggcagtca aagcactgat gatgataaaa tcgttcagta ccattgggaa   1560

gaacttaagg ggcctctaag agaagagaag atttctgaag atacagccat attaaaacta   1620

agtaaactcg tccctgggaa ctacactttc agcttgactg tagtagactc tgatggagct   1680

accaactcta ctactgcaaa cctgacagtg aacaaagctg tggattaccc ccctgtggcc   1740

aacgcaggcc ccaaccaagt gatcaccctg ccccaaaact ccatcaccct ctttgggaac   1800

cagagcactg atgatcatgg catcaccagc tatgagtggt cactcagccc aagcagcaaa   1860

gggaaagtgg tggagatgca gggtgttaga acaccaacct tacagctctc tgcgatgcaa   1920

gaaggagact acacttacca gctcacagtg actgacacaa taggacagca ggccactgct   1980

caagtgactg ttattgtgca acctgaaaac aataagcctc ctcaggcaga tgcaggccca   2040

gataaagagc tgacccttcc tgtggatagc acaaccctgg atggcagcaa gagctcagat   2100

gatcagaaaa ttatctcata tctctgggaa aaaacacagg gacctgatgg ggtgcagctc   2160

gagaatgcta acagcagtgt tgctactgtg actgggctgc aagtggggac ctatgtgttc   2220

accttgactg tcaaagatga gaggaacctg caaagccaga gctctgtgaa tgtcattgtc   2280

aaagaagaaa taaacaaacc acctatagcc aagataactg ggaatgtggt gattacccta   2340

cccacgagca cagcagagct ggatggctct aagtcctcag atgacaaggg aatagtcagc   2400

tacctctgga ctcgagatga ggggagccca gcagcagggg aggtgttaaa tcactctgac   2460

catcacccta tcctttttct ttcaaacctg gttgagggaa cctacacttt tcacctgaaa   2520

gtgaccgatg caaagggtga gagtgacaca gaccggacca ctgtggaggt gaaacctgat   2580

cccaggaaaa acaacctggt ggagatcatc ttggatatca acgtcagtca gctaactgag   2640

aggctgaagg ggatgttcat ccgccagatt ggggtcctcc tgggggtgct ggattccgac   2700

atcattgtgc aaaagattca gccgtacacg gagcagagca ccaaaatggt attttttgtt   2760

caaaacgagc ctccccacca gatcttcaaa ggccatgagg tggcagcgat gctcaagagt   2820

gagctgcgga agcaaaaggc agactttttg atattcagag ccttggaagt caacactgtc   2880

acatgtcagc tgaactgttc cgaccatggc cactgtgact cgttcaccaa acgctgtatc   2940

tgtgaccctt tttggatgga gaatttcatc aaggtgcagc tgagggatgg agacagcaac   3000

tgtgagtgga gcgtgttata tgttatcatt gctacctttg tcattgttgt tgccttggga   3060

atcctgtctt ggactgtgat ctgttgttgt aagaggcaaa aaggaaaacc caagaggaaa   3120

agcaagtaca agatcctgga tgccacggat caggaaagcc tggagctgaa gccaacctcc   3180

cgagcaggca tcaaacagaa aggccttttg ctaagtagca gcctgatgca ctccgagtca   3240

gagctggaca gcgatgatgc catctttaca tggccagacc gagagaaggg caaactcctg   3300

catggtcaga atggctctgt acccaacggg cagacccctc tgaaggccag gagcccgcgg   3360

gaggagatcc tgtagccacc tggtctgtct cctcagggca gggcccagca cactgcccgg   3420

ccagtcctcc tacctcccga gtctgcgggc agctgctgtc ccagcatctg ctggtcattt   3480

cgccctgaca gtcccaacca gaacccctgg gacttgaatc cagagacgtc ctccaggaac   3540

ccctcaacga agctgtgaat gaagaggttt cctctttaaa cctgtctggt gggcccccag   3600

atatcctcac ctcagggcct cctttttttg caaactcctc ccctcccccg agggcagacc   3660

cagccagctg ctaagctctg cagctcccca gtggacagtg tcattgtgcc cagagtgctg   3720

caaggtgagg cctgctgtgc tgcccgcaca cctgagtgca aaaccaagca ctgtgggcat   3780

ggtgtttccc tctctggggt agagtacgcc ctctcgctgg gcaaagagga agtggcaccc   3840

ctcccctcac cacagatgct gagatggtag catagaaatg atggccgggc gcggtggctc   3900

acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg gatcatgagg tcaggagatc   3960

aagaccaccc tggctaacac ggtgaaaccc catctctact aaaaataaaa aaaaaaatta   4020

gccgggtttg gtggcgtatg cctgtaatcc cagctactcg ggaggctgag gcaggagaat   4080

tgcttaaacc tgggaggtgg aggctgcagt gagccaagat cgtgccactg cactccagcc   4140

tgagtgacag agcaagactc cgtc                                          4164


<210>  5854
<211>  1049
<212>  PRT
<213>  Homosapiens

<400>  5854

Met Glu Lys Arg Leu Gly Val Lys Pro Asn Pro Ala Ser Trp Ile Leu 
1               5                   10                  15      


Ser Gly Tyr Tyr Trp Gln Thr Ser Ala Lys Trp Leu Arg Ser Leu Tyr 
            20                  25                  30          


Leu Phe Tyr Thr Cys Phe Cys Phe Ser Val Leu Trp Leu Ser Thr Asp 
        35                  40                  45              


Ala Ser Glu Ser Arg Cys Gln Gln Gly Lys Thr Gln Phe Gly Val Gly 
    50                  55                  60                  


Leu Arg Ser Gly Gly Glu Asn His Leu Trp Leu Leu Glu Gly Thr Pro 
65                  70                  75                  80  


Ser Leu Gln Ser Cys Trp Ala Ala Cys Cys Gln Asp Ser Ala Cys His 
                85                  90                  95      


Val Phe Trp Trp Leu Glu Gly Met Cys Ile Gln Ala Asp Cys Ser Arg 
            100                 105                 110         


Pro Gln Ser Cys Arg Ala Phe Arg Thr His Ser Ser Asn Ser Met Leu 
        115                 120                 125             


Val Phe Leu Lys Lys Phe Gln Thr Ala Asp Asp Leu Gly Phe Leu Pro 
    130                 135                 140                 


Glu Asp Asp Val Pro His Leu Leu Gly Leu Gly Trp Asn Trp Ala Ser 
145                 150                 155                 160 


Trp Arg Gln Ser Pro Pro Arg Ala Ala Leu Arg Pro Ala Val Ser Ser 
                165                 170                 175     


Ser Asp Gln Gln Ser Leu Ile Arg Lys Leu Gln Lys Arg Gly Ser Pro 
            180                 185                 190         


Ser Asp Val Val Thr Pro Ile Val Thr Gln His Ser Lys Val Asn Asp 
        195                 200                 205             


Ser Asn Glu Leu Gly Gly Leu Thr Thr Ser Gly Ser Ala Glu Val His 
    210                 215                 220                 


Lys Ala Ile Thr Ile Ser Ser Pro Leu Thr Thr Asp Leu Thr Ala Glu 
225                 230                 235                 240 


Leu Ser Gly Gly Pro Lys Asn Val Ser Val Gln Pro Glu Ile Ser Glu 
                245                 250                 255     


Gly Leu Ala Thr Thr Pro Ser Thr Gln Gln Val Lys Ser Ser Glu Lys 
            260                 265                 270         


Thr Gln Ile Ala Val Pro Gln Pro Val Ala Pro Ser Tyr Ser Tyr Ala 
        275                 280                 285             


Thr Pro Thr Pro Gln Ala Ser Phe Gln Ser Thr Ser Ala Pro Tyr Pro 
    290                 295                 300                 


Val Ile Lys Glu Leu Val Val Ser Ala Gly Glu Ser Val Gln Ile Thr 
305                 310                 315                 320 


Leu Pro Lys Asn Glu Val Gln Leu Asn Ala Tyr Val Leu Gln Glu Pro 
                325                 330                 335     


Pro Lys Gly Glu Thr Tyr Thr Tyr Asp Trp Gln Leu Ile Thr His Pro 
            340                 345                 350         


Arg Asp Tyr Ser Gly Glu Met Glu Gly Lys His Ser Gln Ile Leu Lys 
        355                 360                 365             


Leu Ser Lys Leu Thr Pro Gly Leu Tyr Glu Phe Lys Val Ile Val Glu 
    370                 375                 380                 


Gly Gln Asn Ala His Gly Glu Gly Tyr Val Asn Val Thr Val Lys Pro 
385                 390                 395                 400 


Glu Pro Arg Lys Asn Arg Pro Pro Ile Ala Ile Val Ser Pro Gln Phe 
                405                 410                 415     


Gln Glu Ile Ser Leu Pro Thr Thr Ser Thr Val Ile Asp Gly Ser Gln 
            420                 425                 430         


Ser Thr Asp Asp Asp Lys Ile Val Gln Tyr His Trp Glu Glu Leu Lys 
        435                 440                 445             


Gly Pro Leu Arg Glu Glu Lys Ile Ser Glu Asp Thr Ala Ile Leu Lys 
    450                 455                 460                 


Leu Ser Lys Leu Val Pro Gly Asn Tyr Thr Phe Ser Leu Thr Val Val 
465                 470                 475                 480 


Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Asn Leu Thr Val Asn 
                485                 490                 495     


Lys Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn Gln Val 
            500                 505                 510         


Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Phe Gly Asn Gln Ser Thr 
        515                 520                 525             


Asp Asp His Gly Ile Thr Ser Tyr Glu Trp Ser Leu Ser Pro Ser Ser 
    530                 535                 540                 


Lys Gly Lys Val Val Glu Met Gln Gly Val Arg Thr Pro Thr Leu Gln 
545                 550                 555                 560 


Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Tyr Gln Leu Thr Val Thr 
                565                 570                 575     


Asp Thr Ile Gly Gln Gln Ala Thr Ala Gln Val Thr Val Ile Val Gln 
            580                 585                 590         


Pro Glu Asn Asn Lys Pro Pro Gln Ala Asp Ala Gly Pro Asp Lys Glu 
        595                 600                 605             


Leu Thr Leu Pro Val Asp Ser Thr Thr Leu Asp Gly Ser Lys Ser Ser 
    610                 615                 620                 


Asp Asp Gln Lys Ile Ile Ser Tyr Leu Trp Glu Lys Thr Gln Gly Pro 
625                 630                 635                 640 


Asp Gly Val Gln Leu Glu Asn Ala Asn Ser Ser Val Ala Thr Val Thr 
                645                 650                 655     


Gly Leu Gln Val Gly Thr Tyr Val Phe Thr Leu Thr Val Lys Asp Glu 
            660                 665                 670         


Arg Asn Leu Gln Ser Gln Ser Ser Val Asn Val Ile Val Lys Glu Glu 
        675                 680                 685             


Ile Asn Lys Pro Pro Ile Ala Lys Ile Thr Gly Asn Val Val Ile Thr 
    690                 695                 700                 


Leu Pro Thr Ser Thr Ala Glu Leu Asp Gly Ser Lys Ser Ser Asp Asp 
705                 710                 715                 720 


Lys Gly Ile Val Ser Tyr Leu Trp Thr Arg Asp Glu Gly Ser Pro Ala 
                725                 730                 735     


Ala Gly Glu Val Leu Asn His Ser Asp His His Pro Ile Leu Phe Leu 
            740                 745                 750         


Ser Asn Leu Val Glu Gly Thr Tyr Thr Phe His Leu Lys Val Thr Asp 
        755                 760                 765             


Ala Lys Gly Glu Ser Asp Thr Asp Arg Thr Thr Val Glu Val Lys Pro 
    770                 775                 780                 


Asp Pro Arg Lys Asn Asn Leu Val Glu Ile Ile Leu Asp Ile Asn Val 
785                 790                 795                 800 


Ser Gln Leu Thr Glu Arg Leu Lys Gly Met Phe Ile Arg Gln Ile Gly 
                805                 810                 815     


Val Leu Leu Gly Val Leu Asp Ser Asp Ile Ile Val Gln Lys Ile Gln 
            820                 825                 830         


Pro Tyr Thr Glu Gln Ser Thr Lys Met Val Phe Phe Val Gln Asn Glu 
        835                 840                 845             


Pro Pro His Gln Ile Phe Lys Gly His Glu Val Ala Ala Met Leu Lys 
    850                 855                 860                 


Ser Glu Leu Arg Lys Gln Lys Ala Asp Phe Leu Ile Phe Arg Ala Leu 
865                 870                 875                 880 


Glu Val Asn Thr Val Thr Cys Gln Leu Asn Cys Ser Asp His Gly His 
                885                 890                 895     


Cys Asp Ser Phe Thr Lys Arg Cys Ile Cys Asp Pro Phe Trp Met Glu 
            900                 905                 910         


Asn Phe Ile Lys Val Gln Leu Arg Asp Gly Asp Ser Asn Cys Glu Trp 
        915                 920                 925             


Ser Val Leu Tyr Val Ile Ile Ala Thr Phe Val Ile Val Val Ala Leu 
    930                 935                 940                 


Gly Ile Leu Ser Trp Thr Val Ile Cys Cys Cys Lys Arg Gln Lys Gly 
945                 950                 955                 960 


Lys Pro Lys Arg Lys Ser Lys Tyr Lys Ile Leu Asp Ala Thr Asp Gln 
                965                 970                 975     


Glu Ser Leu Glu Leu Lys Pro Thr Ser Arg Ala Gly Ile Lys Gln Lys 
            980                 985                 990         


Gly Leu Leu Leu Ser Ser Ser Leu  Met His Ser Glu Ser  Glu Leu Asp 
        995                 1000                 1005             


Ser Asp  Asp Ala Ile Phe Thr  Trp Pro Asp Arg Glu  Lys Gly Lys 
    1010                 1015                 1020             


Leu Leu  His Gly Gln Asn Gly  Ser Val Pro Asn Gly  Gln Thr Pro 
    1025                 1030                 1035             


Leu Lys  Ala Arg Ser Pro Arg  Glu Glu Ile Leu 
    1040                 1045                 


<210>  5855
<211>  5692
<212>  DNA
<213>  Homosapiens

<400>  5855
gtttccggcc gccgtcgctg tccagggagg ctgaggcgag aggtagctgt ccgggtgggg     60

agcccgcact accttcttcc tcttcctcct cctcctccgg gtgaggggag cgaaggttgg    120

gggtccccga gcccatggac caggaggagg cggaggccgc cgagagccgg ggccccgcta    180

tgtggccctg agccccgtgt actggttctg cctgtctgga gggccatgga gaagaggctg    240

ggagtcaagc caaatcctgc ttcctggatt ttatcaggat attattggca gacatctgcg    300

aagtggttga gaagcctgta cctgttttat acttgctttt gcttcagcgt tctgtggttg    360

tcaacagatg ccagtgagag caggtgccag caggggaaga cacaatttgg agttggcctg    420

agatctgggg gagaaaatca cctctggctt cttgaaggaa ccccctctct ccagtcatgt    480

tgggctgcct gctgccagga ctctgcctgc catgtctttt ggtggctaga agggatgtgc    540

attcaggcag actgcagcag gccccagagc tgccgggctt ttaggacaca ctcctccaat    600

tccatgctgg tgtttttaaa aaaattccaa actgcagatg atttgggctt tctacctgaa    660

gatgatgtac cacatcttct ggggctaggt tggaactggg catcttggag gcagagccca    720

cccagagctg cactcagacc tgctgtatct tccagtgacc agcagagctt aatcaggaag    780

cttcagaaga gaggtagtcc cagtgacgta gttacaccta tagtgacaca gcattctaaa    840

gtgaatgact ccaacgaatt aggtggtctg actaccagtg gctctgcaga ggtccacaag    900

gcgattacaa tttccagtcc cctaaccaca gacctgactg cagagctgtc tggtgggcca    960

aagaatgtat cagtgcaacc tgaaatatca gagggtcttg ctactacgcc cagcactcaa   1020

caagtaaaaa gttctgagaa aacccagatt gctgtccccc agccagtggc tccctcctac   1080

agttatgcta cccctacccc ccaggcctct ttccagagca cctcagcacc atacccagtt   1140

ataaaggaac tggtggtatc tgctggagag agtgtccaga taaccctgcc taagaatgaa   1200

gttcaattaa atgcatatgt tctccaagaa ccacctaaag gagaaaccta cacctacgac   1260

tggcagctga ttactcatcc tagagactac agtggagaaa tggaagggaa acattcccag   1320

atcctcaaac tatcgaagct cactccaggc ctgtatgaat tcaaagtgat tgtagagggt   1380

caaaatgccc atggggaagg ctatgtgaac gtgacagtca agccagagcc ccgtaagaat   1440

cggcccccca ttgctattgt gtcacctcag ttccaggaga tctctttgcc aaccacttct   1500

acagtcattg atggcagtca aagcactgat gatgataaaa tcgttcagta ccattgggaa   1560

gaacttaagg ggcctctaag agaagagaag atttctgaag atacagccat attaaaacta   1620

agtaaactcg tccctgggaa ctacactttc agcttgactg tagtagactc tgatggagct   1680

accaactcta ctactgcaaa cctgacagtg aacaaagctg tggattaccc ccctgtggcc   1740

aacgcaggcc ccaaccaagt gatcaccctg ccccaaaact ccatcaccct ctttgggaac   1800

cagagcactg atgatcatgg catcaccagc tatgagtggt cactcagccc aagcagcaaa   1860

gggaaagtgg tggagatgca gggtgttaga acaccaacct tacagctctc tgcgatgcaa   1920

gaaggagact acacttacca gctcacagtg actgacacaa taggacagca ggccactgct   1980

caagtgactg ttattgtgca acctgaaaac aataagcctc ctcaggcaga tgcaggccca   2040

gataaagagc tgacccttcc tgtggatagc acaaccctgg atggcagcaa gagctcagat   2100

gatcagaaaa ttatctcata tctctgggaa aaaacacagg gacctgatgg ggtgcagctc   2160

gagaatgcta acagcagtgt tgctactgtg actgggctgc aagtggggac ctatgtgttc   2220

accttgactg tcaaagatga gaggaacctg caaagccaga gctctgtgaa tgtcattgtc   2280

aaagaagaaa taaacaaacc acctatagcc aagataactg ggaatgtggt gattacccta   2340

cccacgagca cagcagagct ggatggctct aagtcctcag atgacaaggg aatagtcagc   2400

tacctctgga ctcgagatga ggggagccca gcagcagggg aggtgttaaa tcactctgac   2460

catcacccta tcctttttct ttcaaacctg gttgagggaa cctacacttt tcacctgaaa   2520

gtgaccgatg caaagggtga gagtgacaca gaccggacca ctgtggaggt gaaacctgat   2580

cccaggaaaa acaacctggt ggagatcatc ttggatatca acgtcagtca gctaactgag   2640

aggctgaagg ggatgttcat ccgccagatt ggggtcctcc tgggggtgct ggattccgac   2700

atcattgtgc aaaagattca gccgtacacg gagcagagca ccaaaatggt attttttgtt   2760

caaaacgagc ctccccacca gatcttcaaa ggccatgagg tggcagcgat gctcaagagt   2820

gagctgcgga agcaaaaggc agactttttg atattcagag ccttggaagt caacactgtc   2880

acatgtcagc tgaactgttc cgaccatggc cactgtgact cgttcaccaa acgctgtatc   2940

tgtgaccctt tttggatgga gaatttcatc aaggtgcagc tgagggatgg agacagcaac   3000

tgtgagtgga gcgtgttata tgttatcatt gctacctttg tcattgttgt tgccttggga   3060

atcctgtctt ggactgtgat ctgttgttgt aagaggcaaa aaggaaaacc caagaggaaa   3120

agcaagtaca agatcctgga tgccacggat caggaaagcc tggagctgaa gccaacctcc   3180

cgagcaggta ggggccctgg gtgccagagc ttctaggtct gtgcactctc tctgtggaag   3240

gctgctgtca ctagcccctc ctgagtgtgt cactaacagc ccactgtgct tgcaaagcat   3300

tttgttccct tttgcctgat gaagactgag ggtcagattt gccctgagct gcactggaca   3360

aaatgcctcc aggacccact tcgcgtgcta cttccgcttg gcgggggtgc tgggcctgtt   3420

gttttccttt gcctgggcat tctcctcatg tttcccacct ggagttccgc ttttccaact   3480

gccccaggta gtcagggtca gggaccttgg acttgtctct tactgctgac cagtctgtgc   3540

tttatgggca gagatgagac ccaggcccgt gtctgccagc tgaccacctt tcagccagcc   3600

ttgttctcct gtcttcctat ctttatcatt tggcaagtcc tcagcttctg tcagtgtctt   3660

agggcagata ggagggcatt tccttgcaca aacagtaaga tgactttgag tgatggcact   3720

gggagatcag ggcaggtagt aggccttcct tcctccgctg ggctgggtca cctggcgagg   3780

gtttcactca tcatggatgc catgggacag gtatcattgg tttatgagag ctagactcta   3840

taaagcgatt cctaaacact ctgcaagtag aactattttt atataaagca tttattaaac   3900

acttttcatg cttaaagctt tgtgttaggg agaggctatg ggggtatagg gagtcatcag   3960

acacaggctg tgctctcagt ctagtgaggg agaaaagaca cacagtagca gaagagaaca   4020

ggctcacagc agtctggact ctgcaccaag cagctcgatc caccaacact gtcaaggtgg   4080

agactggagg tggtggggct tgaaatgagc ccaggaaacc agagcagtga gggcgggcgg   4140

ggcatttcac ccaggaatat tgagaatgag ggcctggagg tgaaatgtgc aaaacccacc   4200

cctcacactg cagccaaggt ttttatcatg ttactctgat catgtttttc accccctgac   4260

attcttcaat gacttactat ttctagcaca aaaagctaga acttttggtc tggtagatgt   4320

ggcctttgtg agcttacatc agtttgcttt tctggaatct ttctctttgc tgatctccct   4380

cttttctaaa caagttcttc tggttcatcc agtaatctct ttctttttta aaaatgtggc   4440

gacaaggtct tgctctgtca cccaggctgg agtgcagtgg tatagtcata gctcactgca   4500

acctccagct cctgagctca agtggtcctc ctgcttcagc ctcccaaagc agctgggact   4560

acaggcatgc accaccatac ccagccctag aaagctcttt cttatccctc ccttaacctc   4620

ctcaagttgt gctcaccttt ctctcacatg cctgggtcgg catttctctc gctgtctcat   4680

gattagttat gtttgcctgt ctccccaccc atcagtgaaa tccctgaggg caggggctgt   4740

ctcattcatc tgtggatatg gagcgggacc actatgtgcc aggccctgtg ccagacactg   4800

cttatattgt ggtgaatcaa acggacagac ttcactcttg tgtagcttat gtcagacaga   4860

cattaagcaa actcacaaat acataaaata tgctcataaa aggcctttat gaagaaaaac   4920

acttaagctg agacctggat aagtgggagc tagccagata aagctgcagg aaatagcatt   4980

ccaggcaaag gaacaaaact ggtgcagacc cagctgctag aaggagcaga gagcatttga   5040

ggaggtagaa gaaggtgaca tgatggacag gttcaccttc ccacagagta aggggtgagt   5100

gacccaaggc tcaatggatg agcagggtcc ctgctgagga cttctcttga gtacaatggg   5160

gagccactga tagcttttta aggggatgaa tggtgggatt tggtttacat ttattattat   5220

ttgagacaga gtctcactct tatcacccag gcaggagtgc agtggtgcga tcaaggccca   5280

ctgcagtctt gacctcctgg gctcaggtga tccttccacc tcagcttcct aagtagctgg   5340

gaccacaggc atgcgccacc atccccaggt ttttttgttg ttgttgttgt tgttttgtat   5400

ttttggtaga gacggggttt catcatgttg cctaggctgt tcttgaactc ctgggcttaa   5460

gtgatctgcc tgccttggtc tcctaaagtg ctgggattat aggtgtgagc catggcaccc   5520

ggtcttggtt tatattttaa aaagacaact gtgtagctgg gcgtggtggt gggtgcctgt   5580

aatcccagct actcgagagg ccaaggcagg agaattgcta gaacctgggg gtgtgaaggt   5640

ttcagtgaac tgagatcact ccaacctggg caataaagcc agactctgtc tc           5692


<210>  5856
<211>  996
<212>  PRT
<213>  Homosapiens

<400>  5856

Met Glu Lys Arg Leu Gly Val Lys Pro Asn Pro Ala Ser Trp Ile Leu 
1               5                   10                  15      


Ser Gly Tyr Tyr Trp Gln Thr Ser Ala Lys Trp Leu Arg Ser Leu Tyr 
            20                  25                  30          


Leu Phe Tyr Thr Cys Phe Cys Phe Ser Val Leu Trp Leu Ser Thr Asp 
        35                  40                  45              


Ala Ser Glu Ser Arg Cys Gln Gln Gly Lys Thr Gln Phe Gly Val Gly 
    50                  55                  60                  


Leu Arg Ser Gly Gly Glu Asn His Leu Trp Leu Leu Glu Gly Thr Pro 
65                  70                  75                  80  


Ser Leu Gln Ser Cys Trp Ala Ala Cys Cys Gln Asp Ser Ala Cys His 
                85                  90                  95      


Val Phe Trp Trp Leu Glu Gly Met Cys Ile Gln Ala Asp Cys Ser Arg 
            100                 105                 110         


Pro Gln Ser Cys Arg Ala Phe Arg Thr His Ser Ser Asn Ser Met Leu 
        115                 120                 125             


Val Phe Leu Lys Lys Phe Gln Thr Ala Asp Asp Leu Gly Phe Leu Pro 
    130                 135                 140                 


Glu Asp Asp Val Pro His Leu Leu Gly Leu Gly Trp Asn Trp Ala Ser 
145                 150                 155                 160 


Trp Arg Gln Ser Pro Pro Arg Ala Ala Leu Arg Pro Ala Val Ser Ser 
                165                 170                 175     


Ser Asp Gln Gln Ser Leu Ile Arg Lys Leu Gln Lys Arg Gly Ser Pro 
            180                 185                 190         


Ser Asp Val Val Thr Pro Ile Val Thr Gln His Ser Lys Val Asn Asp 
        195                 200                 205             


Ser Asn Glu Leu Gly Gly Leu Thr Thr Ser Gly Ser Ala Glu Val His 
    210                 215                 220                 


Lys Ala Ile Thr Ile Ser Ser Pro Leu Thr Thr Asp Leu Thr Ala Glu 
225                 230                 235                 240 


Leu Ser Gly Gly Pro Lys Asn Val Ser Val Gln Pro Glu Ile Ser Glu 
                245                 250                 255     


Gly Leu Ala Thr Thr Pro Ser Thr Gln Gln Val Lys Ser Ser Glu Lys 
            260                 265                 270         


Thr Gln Ile Ala Val Pro Gln Pro Val Ala Pro Ser Tyr Ser Tyr Ala 
        275                 280                 285             


Thr Pro Thr Pro Gln Ala Ser Phe Gln Ser Thr Ser Ala Pro Tyr Pro 
    290                 295                 300                 


Val Ile Lys Glu Leu Val Val Ser Ala Gly Glu Ser Val Gln Ile Thr 
305                 310                 315                 320 


Leu Pro Lys Asn Glu Val Gln Leu Asn Ala Tyr Val Leu Gln Glu Pro 
                325                 330                 335     


Pro Lys Gly Glu Thr Tyr Thr Tyr Asp Trp Gln Leu Ile Thr His Pro 
            340                 345                 350         


Arg Asp Tyr Ser Gly Glu Met Glu Gly Lys His Ser Gln Ile Leu Lys 
        355                 360                 365             


Leu Ser Lys Leu Thr Pro Gly Leu Tyr Glu Phe Lys Val Ile Val Glu 
    370                 375                 380                 


Gly Gln Asn Ala His Gly Glu Gly Tyr Val Asn Val Thr Val Lys Pro 
385                 390                 395                 400 


Glu Pro Arg Lys Asn Arg Pro Pro Ile Ala Ile Val Ser Pro Gln Phe 
                405                 410                 415     


Gln Glu Ile Ser Leu Pro Thr Thr Ser Thr Val Ile Asp Gly Ser Gln 
            420                 425                 430         


Ser Thr Asp Asp Asp Lys Ile Val Gln Tyr His Trp Glu Glu Leu Lys 
        435                 440                 445             


Gly Pro Leu Arg Glu Glu Lys Ile Ser Glu Asp Thr Ala Ile Leu Lys 
    450                 455                 460                 


Leu Ser Lys Leu Val Pro Gly Asn Tyr Thr Phe Ser Leu Thr Val Val 
465                 470                 475                 480 


Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Asn Leu Thr Val Asn 
                485                 490                 495     


Lys Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn Gln Val 
            500                 505                 510         


Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Phe Gly Asn Gln Ser Thr 
        515                 520                 525             


Asp Asp His Gly Ile Thr Ser Tyr Glu Trp Ser Leu Ser Pro Ser Ser 
    530                 535                 540                 


Lys Gly Lys Val Val Glu Met Gln Gly Val Arg Thr Pro Thr Leu Gln 
545                 550                 555                 560 


Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Tyr Gln Leu Thr Val Thr 
                565                 570                 575     


Asp Thr Ile Gly Gln Gln Ala Thr Ala Gln Val Thr Val Ile Val Gln 
            580                 585                 590         


Pro Glu Asn Asn Lys Pro Pro Gln Ala Asp Ala Gly Pro Asp Lys Glu 
        595                 600                 605             


Leu Thr Leu Pro Val Asp Ser Thr Thr Leu Asp Gly Ser Lys Ser Ser 
    610                 615                 620                 


Asp Asp Gln Lys Ile Ile Ser Tyr Leu Trp Glu Lys Thr Gln Gly Pro 
625                 630                 635                 640 


Asp Gly Val Gln Leu Glu Asn Ala Asn Ser Ser Val Ala Thr Val Thr 
                645                 650                 655     


Gly Leu Gln Val Gly Thr Tyr Val Phe Thr Leu Thr Val Lys Asp Glu 
            660                 665                 670         


Arg Asn Leu Gln Ser Gln Ser Ser Val Asn Val Ile Val Lys Glu Glu 
        675                 680                 685             


Ile Asn Lys Pro Pro Ile Ala Lys Ile Thr Gly Asn Val Val Ile Thr 
    690                 695                 700                 


Leu Pro Thr Ser Thr Ala Glu Leu Asp Gly Ser Lys Ser Ser Asp Asp 
705                 710                 715                 720 


Lys Gly Ile Val Ser Tyr Leu Trp Thr Arg Asp Glu Gly Ser Pro Ala 
                725                 730                 735     


Ala Gly Glu Val Leu Asn His Ser Asp His His Pro Ile Leu Phe Leu 
            740                 745                 750         


Ser Asn Leu Val Glu Gly Thr Tyr Thr Phe His Leu Lys Val Thr Asp 
        755                 760                 765             


Ala Lys Gly Glu Ser Asp Thr Asp Arg Thr Thr Val Glu Val Lys Pro 
    770                 775                 780                 


Asp Pro Arg Lys Asn Asn Leu Val Glu Ile Ile Leu Asp Ile Asn Val 
785                 790                 795                 800 


Ser Gln Leu Thr Glu Arg Leu Lys Gly Met Phe Ile Arg Gln Ile Gly 
                805                 810                 815     


Val Leu Leu Gly Val Leu Asp Ser Asp Ile Ile Val Gln Lys Ile Gln 
            820                 825                 830         


Pro Tyr Thr Glu Gln Ser Thr Lys Met Val Phe Phe Val Gln Asn Glu 
        835                 840                 845             


Pro Pro His Gln Ile Phe Lys Gly His Glu Val Ala Ala Met Leu Lys 
    850                 855                 860                 


Ser Glu Leu Arg Lys Gln Lys Ala Asp Phe Leu Ile Phe Arg Ala Leu 
865                 870                 875                 880 


Glu Val Asn Thr Val Thr Cys Gln Leu Asn Cys Ser Asp His Gly His 
                885                 890                 895     


Cys Asp Ser Phe Thr Lys Arg Cys Ile Cys Asp Pro Phe Trp Met Glu 
            900                 905                 910         


Asn Phe Ile Lys Val Gln Leu Arg Asp Gly Asp Ser Asn Cys Glu Trp 
        915                 920                 925             


Ser Val Leu Tyr Val Ile Ile Ala Thr Phe Val Ile Val Val Ala Leu 
    930                 935                 940                 


Gly Ile Leu Ser Trp Thr Val Ile Cys Cys Cys Lys Arg Gln Lys Gly 
945                 950                 955                 960 


Lys Pro Lys Arg Lys Ser Lys Tyr Lys Ile Leu Asp Ala Thr Asp Gln 
                965                 970                 975     


Glu Ser Leu Glu Leu Lys Pro Thr Ser Arg Ala Gly Arg Gly Pro Gly 
            980                 985                 990         


Cys Gln Ser Phe 
        995     


<210>  5857
<211>  465
<212>  DNA
<213>  Homosapiens

<400>  5857
aaaaaaacaa aaaaccaaaa acctttcact ataagaaatg tgggaaagcc ttcgggtaca     60

gccaaggcct tgctgaaaat cagaaaatcc atatcttatg aatgtaatga atgtgggaag    120

cttttcccca aagttcagcc cttaaacaac ataagaaaat ttataacaaa gtcatcaagc    180

caggcatggt ggctcatgcc tataatccca gcactttggg aagatgaggt gggaggacca    240

cttgagccca tgagttcaag accagactgg gcaacatagt gagaccccat ctctacaaaa    300

gataaaaatt actaaaaaat aacattttta aaaagaatgg gtcatcaaat gtagtgtggt    360

aaacatgcaa aagtagttta tttcttctga ccatcaaaga tggaaaaagc aagttgcaga    420

aaatctatat attatgttct tatttatatt tttaacaatg aagct                    465


<210>  5858
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  5858

Met Trp Glu Ala Phe Pro Gln Ser Ser Ala Leu Lys Gln His Lys Lys 
1               5                   10                  15      


Ile Tyr Asn Lys Val Ile Lys Pro Gly Met Val Ala His Ala Tyr Asn 
            20                  25                  30          


Pro Ser Thr Leu Gly Arg 
        35              


<210>  5859
<211>  3684
<212>  DNA
<213>  Homosapiens

<400>  5859
cctcccccgg gaagggcaat gccggccgcg agaccaaggg ggaggagggg cagtgctggg     60

cgggtaaaac tacgcacaag cgaaggaatc tgggccccca gcctctcgcc gcccgctctc    120

cagaggcagt ctgcaccttg cctccttcgc tcgagcccca gcccccagac tcgggcaata    180

cccacaagca agatggcggc aacggcggca ccccctactg cttagcaccc tgacttgcca    240

ttggccagag cccggagtga agcagccgcg gattcgtcaa gagcggtgcg ggggtggggg    300

tggagctgca gcagcctgga gccaggagtg ggcaacgcgg cgtgagcagc ggcccgaggc    360

tcccggagca tcgcgctggg agaagacttc gccgctcggg gccgcagcct gttgggcaag    420

gcgagcatca tggcctcgga ttgcgagcca gctctgaacc aggcagaggg ccgaaacccc    480

accctggagc gctacctggg agccctccgt gaggccaaga atgacagcga gcagtttgca    540

gccctgctgc tagtgaccaa ggcagtcaaa gcaggtgaca tagatgccaa aactcggcgg    600

cggatcttcg atgctgtcgg cttcaccttc cccaatcgtc tcctgaccac caaggaggcg    660

ccggatggct gccctgacca tgttctgcgg gctttgggtg tggccctgct ggcctgcttc    720

tgcagtgacc ctgaactggc cgcccatccc caagtcctga acaagattcc cattcttagc    780

accttcctca cagcccgggg ggacccggac gatgctgccc gccgctccat gattgatgac    840

acctaccagt gcctgacggc tgtagcaggc acacccagag ggcctcggca cctcattgct    900

ggtggcaccg tgtctgccct atgccaggca tacctggggc acggctatgg ctttgaccag    960

gccctggcac tcctggtggg gctgctggct gctgccgaga cacagtgctg gaaggaggcg   1020

gagcccgacc tgctggccgt gttgcggggc ctcagtgagg atttccagaa agctgaggat   1080

gccagcaagt ttgagctctg ccagctgctg cccctctttt tgcccccgac aaccgtgccc   1140

cctgaatgct accgggatct gcaggccggg ctggcacgca tcctgggaag caagctgagc   1200

tcctggcagc gcaaccctgc actgaagctg gcagcccgcc tggcacacgc ctgcggctcc   1260

gactggatcc cggcgggcag ctccgggagc aagttcctgg ccctgctggt gaatctggcg   1320

tgcgtggaag tgcggctggc actggaggag acgggcacgg aggtgaaaga ggatgtggtg   1380

accgcctgct atgccctcat ggagttgggg atccaggaat gcactcgctg tgagcagtca   1440

ctgcttaagg agccacagaa ggtgcagctc gtgagcgtca tgaaggaggc cataggggct   1500

gttatccact acctgctgca ggtggggtca gagaagcaga aggagccctt tgtgtttgcc   1560

tcggtgcgga tcctgggtgc ctggctggcc gaggagacct catccttgcg taaggaggtg   1620

tgccagctgc tgcccttcct cgtccgctat gccaagaccc tctacgagga ggccgaggag   1680

gccaatgacc tttcccagca ggtggccaac ctggccatct cccccaccac cccagggccc   1740

acctggccag gagacgctct ccggctcctc ctgcctggct ggtgccacct gaccgttgaa   1800

gatgggcccc gggagatcct gatcaaggaa ggggccccct cgcttctgtg caagtatttc   1860

ctgcagcagt gggaactcac atcccctggc cacgacacct cggtgctgcc tgacagcgtg   1920

gagattggcc tgcagacctg ctgccacatc ttcctcaacc tcgtggtcac cgcaccgggg   1980

ctgatcaagc gtgacgcctg cttcacatct ctaatgaaca ccctcatgac gtcgctacca   2040

gcactagtgc agcaacaggg aaggctgctt ctggctgcta atgtggccac cctggggctc   2100

ctcatggccc ggctccttag cacctctcca gctcttcagg gaacaccagc atcccgaggg   2160

ttcttcgcag ctgccatcct cttcctatca cagtcccacg tggcgcgggc caccccgggc   2220

tcagaccagg cagtgctagc cctgtcccct gagtatgagg gcatctgggc cgacctgcag   2280

gagctctggt tcctgggcat gcaggccttc accggctgtg tgcctctgct gccctggctg   2340

gcccccgctg ccctgcgctc ccgctggccg caggagctgc tccagctgct aggcagtgtc   2400

agccccaact ctgtcaagcc cgagatggtg gccgcctatc agggtgtcct ggtggagctg   2460

gcgcgggcca accggctgtg ccgggaggcc atgaggctgc aggcgggcga ggagacggcc   2520

agccactacc gcatggctgc cttggagcag tgcctgtcag agccctgagg ggtgtccacc   2580

ggggacagac ccaggggcgg gcagagaggg aaggagggag gaggcatctt ccctgaagcc   2640

cccaatctgg cccccccctc cccagacttc ctccccaaaa caccccagct ttctggcttt   2700

tctgagggca agggcatggt gcccacccct caagtgtaag gaactgcgtt ccgcccctca   2760

ggcccccatg ggggcaggga tcggcttgga aatcaacgtg gttgtccccg ccaggccggg   2820

gaaggttgga gcagccccca gggagggggg cactaggtgt cattgtgccc gatgtctggc   2880

tcccctgcag gagggaggct ccagggtaag acagggctgg caggagcaga ctgcctcagc   2940

ccatgtgccc tgccggccag ggcgtgggct cccctcggct gtggtgcctc ctctggcccc   3000

ccaggtccac gtcctttaaa ttggcccttt ggctcttgcc cttggctccc ttgggcagac   3060

agcaggctta ggccattgat atcgcagttc ttcctatcag cttcagtgac ccagggtctg   3120

aactgcctcc atcctagggc aacctggggc agacaggcct ggtggggggt ggggaaacct   3180

ccttccacct gagcttgctt gaagggaccc agagtctttg ggcccagatc tttaaacctt   3240

tgtgtcgtgt tgcagcagag tgacgatggg ggttgggggg ttatttattt tgcctgtcct   3300

tatccctgct tggacacctg agcatctgat tcctgtcccc ctggtgccat ctggcctggc   3360

tggagccagg aacaggaggg acacttcccc agaatccgca tgtttcccca gtgattacac   3420

tccactgcca ccgtggtgcc tggctttaac tcccacccct gctatgactc ctctctgcag   3480

agacgcgact ggcggctcca gcagggacta cctttcttat aaacccaggg ggaccacaca   3540

cacacacaca cacacacaca cacacacaca cacacacaca cacactcttg atcccttgct   3600

tccctccccc agtgcgttct gtgatcgcca agttcaaagc tgtgcacatg tggacactca   3660

ataaatgttc attggtgacg agaa                                          3684


<210>  5860
<211>  712
<212>  PRT
<213>  Homosapiens

<400>  5860

Met Ala Ser Asp Cys Glu Pro Ala Leu Asn Gln Ala Glu Gly Arg Asn 
1               5                   10                  15      


Pro Thr Leu Glu Arg Tyr Leu Gly Ala Leu Arg Glu Ala Lys Asn Asp 
            20                  25                  30          


Ser Glu Gln Phe Ala Ala Leu Leu Leu Val Thr Lys Ala Val Lys Ala 
        35                  40                  45              


Gly Asp Ile Asp Ala Lys Thr Arg Arg Arg Ile Phe Asp Ala Val Gly 
    50                  55                  60                  


Phe Thr Phe Pro Asn Arg Leu Leu Thr Thr Lys Glu Ala Pro Asp Gly 
65                  70                  75                  80  


Cys Pro Asp His Val Leu Arg Ala Leu Gly Val Ala Leu Leu Ala Cys 
                85                  90                  95      


Phe Cys Ser Asp Pro Glu Leu Ala Ala His Pro Gln Val Leu Asn Lys 
            100                 105                 110         


Ile Pro Ile Leu Ser Thr Phe Leu Thr Ala Arg Gly Asp Pro Asp Asp 
        115                 120                 125             


Ala Ala Arg Arg Ser Met Ile Asp Asp Thr Tyr Gln Cys Leu Thr Ala 
    130                 135                 140                 


Val Ala Gly Thr Pro Arg Gly Pro Arg His Leu Ile Ala Gly Gly Thr 
145                 150                 155                 160 


Val Ser Ala Leu Cys Gln Ala Tyr Leu Gly His Gly Tyr Gly Phe Asp 
                165                 170                 175     


Gln Ala Leu Ala Leu Leu Val Gly Leu Leu Ala Ala Ala Glu Thr Gln 
            180                 185                 190         


Cys Trp Lys Glu Ala Glu Pro Asp Leu Leu Ala Val Leu Arg Gly Leu 
        195                 200                 205             


Ser Glu Asp Phe Gln Lys Ala Glu Asp Ala Ser Lys Phe Glu Leu Cys 
    210                 215                 220                 


Gln Leu Leu Pro Leu Phe Leu Pro Pro Thr Thr Val Pro Pro Glu Cys 
225                 230                 235                 240 


Tyr Arg Asp Leu Gln Ala Gly Leu Ala Arg Ile Leu Gly Ser Lys Leu 
                245                 250                 255     


Ser Ser Trp Gln Arg Asn Pro Ala Leu Lys Leu Ala Ala Arg Leu Ala 
            260                 265                 270         


His Ala Cys Gly Ser Asp Trp Ile Pro Ala Gly Ser Ser Gly Ser Lys 
        275                 280                 285             


Phe Leu Ala Leu Leu Val Asn Leu Ala Cys Val Glu Val Arg Leu Ala 
    290                 295                 300                 


Leu Glu Glu Thr Gly Thr Glu Val Lys Glu Asp Val Val Thr Ala Cys 
305                 310                 315                 320 


Tyr Ala Leu Met Glu Leu Gly Ile Gln Glu Cys Thr Arg Cys Glu Gln 
                325                 330                 335     


Ser Leu Leu Lys Glu Pro Gln Lys Val Gln Leu Val Ser Val Met Lys 
            340                 345                 350         


Glu Ala Ile Gly Ala Val Ile His Tyr Leu Leu Gln Val Gly Ser Glu 
        355                 360                 365             


Lys Gln Lys Glu Pro Phe Val Phe Ala Ser Val Arg Ile Leu Gly Ala 
    370                 375                 380                 


Trp Leu Ala Glu Glu Thr Ser Ser Leu Arg Lys Glu Val Cys Gln Leu 
385                 390                 395                 400 


Leu Pro Phe Leu Val Arg Tyr Ala Lys Thr Leu Tyr Glu Glu Ala Glu 
                405                 410                 415     


Glu Ala Asn Asp Leu Ser Gln Gln Val Ala Asn Leu Ala Ile Ser Pro 
            420                 425                 430         


Thr Thr Pro Gly Pro Thr Trp Pro Gly Asp Ala Leu Arg Leu Leu Leu 
        435                 440                 445             


Pro Gly Trp Cys His Leu Thr Val Glu Asp Gly Pro Arg Glu Ile Leu 
    450                 455                 460                 


Ile Lys Glu Gly Ala Pro Ser Leu Leu Cys Lys Tyr Phe Leu Gln Gln 
465                 470                 475                 480 


Trp Glu Leu Thr Ser Pro Gly His Asp Thr Ser Val Leu Pro Asp Ser 
                485                 490                 495     


Val Glu Ile Gly Leu Gln Thr Cys Cys His Ile Phe Leu Asn Leu Val 
            500                 505                 510         


Val Thr Ala Pro Gly Leu Ile Lys Arg Asp Ala Cys Phe Thr Ser Leu 
        515                 520                 525             


Met Asn Thr Leu Met Thr Ser Leu Pro Ala Leu Val Gln Gln Gln Gly 
    530                 535                 540                 


Arg Leu Leu Leu Ala Ala Asn Val Ala Thr Leu Gly Leu Leu Met Ala 
545                 550                 555                 560 


Arg Leu Leu Ser Thr Ser Pro Ala Leu Gln Gly Thr Pro Ala Ser Arg 
                565                 570                 575     


Gly Phe Phe Ala Ala Ala Ile Leu Phe Leu Ser Gln Ser His Val Ala 
            580                 585                 590         


Arg Ala Thr Pro Gly Ser Asp Gln Ala Val Leu Ala Leu Ser Pro Glu 
        595                 600                 605             


Tyr Glu Gly Ile Trp Ala Asp Leu Gln Glu Leu Trp Phe Leu Gly Met 
    610                 615                 620                 


Gln Ala Phe Thr Gly Cys Val Pro Leu Leu Pro Trp Leu Ala Pro Ala 
625                 630                 635                 640 


Ala Leu Arg Ser Arg Trp Pro Gln Glu Leu Leu Gln Leu Leu Gly Ser 
                645                 650                 655     


Val Ser Pro Asn Ser Val Lys Pro Glu Met Val Ala Ala Tyr Gln Gly 
            660                 665                 670         


Val Leu Val Glu Leu Ala Arg Ala Asn Arg Leu Cys Arg Glu Ala Met 
        675                 680                 685             


Arg Leu Gln Ala Gly Glu Glu Thr Ala Ser His Tyr Arg Met Ala Ala 
    690                 695                 700                 


Leu Glu Gln Cys Leu Ser Glu Pro 
705                 710         


<210>  5861
<211>  3431
<212>  DNA
<213>  Homosapiens

<400>  5861
ccaggagtgg gcaacgcggc gtgagcagcg gcccgaggct cccggagcat cgcgctggga     60

gaagacttcg ccgctcgggg ccgcagcctg tgtgatctca tcgccgccct gtcgtgactt    120

catcaatgtc gtgttgtgac ctggctgcgg cgggacagtt gggcaaggcg agcatcatgg    180

cctcggattg cgagccagct ctgaaccagg cagagggccg aaaccccacc ctggagcgct    240

acctgggagc cctccgtgag gccaagaatg acagcgagca gtttgcagcc ctgctgctag    300

tgaccaaggc agtcaaagca ggtgacatag atgccaaaac tcggcggcgg atcttcgatg    360

ctgtcggctt caccttcccc aatcgtctcc tgaccaccaa ggaggcgccg gatggctgcc    420

ctgaccatgt tctgcgggct ttgggtgtgg ccctgctggc ctgcttctgc agtgaccctg    480

aactggccgc ccatccccaa gtcctgaaca agattcccat tcttagcacc ttcctcacag    540

cccgggggga cccggacgat gctgcccgcc gctccatgat tgatgacacc taccagtgcc    600

tgacggctgt agcaggcaca cccagagggc ctcggcacct cattgctggt ggcaccgtgt    660

ctgccctatg ccaggcatac ctggggcacg gctatggctt tgaccaggcc ctggcactcc    720

tggtggggct gctggctgct gccgagacac agtgctggaa ggaggcggag cccgacctgc    780

tggccgtgtt gcggggcctc agtgaggatt tccagaaagc tgaggatgcc agcaagtttg    840

agctctgcca gctgctgccc ctctttttgc ccccgacaac cgtgccccct gaatgctacc    900

gggatctgca ggccgggctg gcacgcatcc tgggaagcaa gctgagctcc tggcagcgca    960

accctgcact gaagctggca gcccgcctgg cacacgcctg cggctccgac tggatcccgg   1020

cgggcagctc cgggagcaag ttcctggccc tgctggtgaa tctggcgtgc gtggaagtgc   1080

ggctggcact ggaggagacg ggcacggagg tgaaagagga tgtggtgacc gcctgctatg   1140

ccctcatgga gttggggatc caggaatgca ctcgctgtga gcagtcactg cttaaggagc   1200

cacagaaggt gcagctcgtg agcgtcatga aggaggccat aggggctgtt atccactacc   1260

tgctgcaggt ggggtcagag aagcagaagg agccctttgt gtttgcctcg gtgcggatcc   1320

tgggtgcctg gctggccgag gagacctcat ccttgcgtaa ggaggtgtgc cagctgctgc   1380

ccttcctcgt ccgctatgcc aagaccctct acgaggaggc cgaggaggcc aatgaccttt   1440

cccagcaggt ggccaacctg gccatctccc ccaccacccc agggcccacc tggccaggag   1500

acgctctccg gctcctcctg cctggctggt gccacctgac cgttgaagat gggccccggg   1560

agatcctgat caaggaaggg gccccctcgc ttctgtgcaa gtatttcctg cagcagtggg   1620

aactcacatc ccctggccac gacacctcgg tgctgcctga cagcgtggag attggcctgc   1680

agacctgctg ccacatcttc ctcaacctcg tggtcaccgc accggggctg atcaagcgtg   1740

acgcctgctt cacatctcta atgaacaccc tcatgacgtc gctaccagca ctagtgcagc   1800

aacagggaag gctgcttctg gctgctaatg tggccaccct ggggctcctc atggcccggc   1860

tccttagcac ctctccagct cttcagggaa caccagcatc ccgagggttc ttcgcagctg   1920

ccatcctctt cctatcacag tcccacgtgg cgcgggccac cccgggctca gaccaggcag   1980

tgctagccct gtcccctgag tatgagggca tctgggccga cctgcaggag ctctggttcc   2040

tgggcatgca ggccttcacc ggctgtgtgc ctctgctgcc ctggctggcc cccgctgccc   2100

tgcgctcccg ctggccgcag gagctgctcc agctgctagg cagtgtcagc cccaactctg   2160

tcaagcccga gatggtggcc gcctatcagg gtgtcctggt ggagctggcg cgggccaacc   2220

ggctgtgccg ggaggccatg aggctgcagg cgggcgagga gacggccagc cactaccgca   2280

tggctgcctt ggagcagtgc ctgtcagagc cctgaggggt gtccaccggg gacagaccca   2340

ggggcgggca gagagggaag gagggaggag gcatcttccc tgaagccccc aatctggccc   2400

ccccctcccc agacttcctc cccaaaacac cccagctttc tggcttttct gagggcaagg   2460

gcatggtgcc cacccctcaa gtgtaaggaa ctgcgttccg cccctcaggc ccccatgggg   2520

gcagggatcg gcttggaaat caacgtggtt gtccccgcca ggccggggaa ggttggagca   2580

gcccccaggg aggggggcac taggtgtcat tgtgcccgat gtctggctcc cctgcaggag   2640

ggaggctcca gggtaagaca gggctggcag gagcagactg cctcagccca tgtgccctgc   2700

cggccagggc gtgggctccc ctcggctgtg gtgcctcctc tggcccccca ggtccacgtc   2760

ctttaaattg gccctttggc tcttgccctt ggctcccttg ggcagacagc aggcttaggc   2820

cattgatatc gcagttcttc ctatcagctt cagtgaccca gggtctgaac tgcctccatc   2880

ctagggcaac ctggggcaga caggcctggt ggggggtggg gaaacctcct tccacctgag   2940

cttgcttgaa gggacccaga gtctttgggc ccagatcttt aaacctttgt gtcgtgttgc   3000

agcagagtga cgatgggggt tggggggtta tttattttgc ctgtccttat ccctgcttgg   3060

acacctgagc atctgattcc tgtccccctg gtgccatctg gcctggctgg agccaggaac   3120

aggagggaca cttccccaga atccgcatgt ttccccagtg attacactcc actgccaccg   3180

tggtgcctgg ctttaactcc cacccctgct atgactcctc tctgcagaga cgcgactggc   3240

ggctccagca gggactacct ttcttataaa cccaggggga ccacacacac acacacacac   3300

acacacacac acacacacac acacacacac actcttgatc ccttgcttcc ctcccccagt   3360

gcgttctgtg atcgccaagt tcaaagctgt gcacatgtgg acactcaata aatgttcatt   3420

ggtgacgaga a                                                        3431


<210>  5862
<211>  729
<212>  PRT
<213>  Homosapiens

<400>  5862

Met Ser Cys Cys Asp Leu Ala Ala Ala Gly Gln Leu Gly Lys Ala Ser 
1               5                   10                  15      


Ile Met Ala Ser Asp Cys Glu Pro Ala Leu Asn Gln Ala Glu Gly Arg 
            20                  25                  30          


Asn Pro Thr Leu Glu Arg Tyr Leu Gly Ala Leu Arg Glu Ala Lys Asn 
        35                  40                  45              


Asp Ser Glu Gln Phe Ala Ala Leu Leu Leu Val Thr Lys Ala Val Lys 
    50                  55                  60                  


Ala Gly Asp Ile Asp Ala Lys Thr Arg Arg Arg Ile Phe Asp Ala Val 
65                  70                  75                  80  


Gly Phe Thr Phe Pro Asn Arg Leu Leu Thr Thr Lys Glu Ala Pro Asp 
                85                  90                  95      


Gly Cys Pro Asp His Val Leu Arg Ala Leu Gly Val Ala Leu Leu Ala 
            100                 105                 110         


Cys Phe Cys Ser Asp Pro Glu Leu Ala Ala His Pro Gln Val Leu Asn 
        115                 120                 125             


Lys Ile Pro Ile Leu Ser Thr Phe Leu Thr Ala Arg Gly Asp Pro Asp 
    130                 135                 140                 


Asp Ala Ala Arg Arg Ser Met Ile Asp Asp Thr Tyr Gln Cys Leu Thr 
145                 150                 155                 160 


Ala Val Ala Gly Thr Pro Arg Gly Pro Arg His Leu Ile Ala Gly Gly 
                165                 170                 175     


Thr Val Ser Ala Leu Cys Gln Ala Tyr Leu Gly His Gly Tyr Gly Phe 
            180                 185                 190         


Asp Gln Ala Leu Ala Leu Leu Val Gly Leu Leu Ala Ala Ala Glu Thr 
        195                 200                 205             


Gln Cys Trp Lys Glu Ala Glu Pro Asp Leu Leu Ala Val Leu Arg Gly 
    210                 215                 220                 


Leu Ser Glu Asp Phe Gln Lys Ala Glu Asp Ala Ser Lys Phe Glu Leu 
225                 230                 235                 240 


Cys Gln Leu Leu Pro Leu Phe Leu Pro Pro Thr Thr Val Pro Pro Glu 
                245                 250                 255     


Cys Tyr Arg Asp Leu Gln Ala Gly Leu Ala Arg Ile Leu Gly Ser Lys 
            260                 265                 270         


Leu Ser Ser Trp Gln Arg Asn Pro Ala Leu Lys Leu Ala Ala Arg Leu 
        275                 280                 285             


Ala His Ala Cys Gly Ser Asp Trp Ile Pro Ala Gly Ser Ser Gly Ser 
    290                 295                 300                 


Lys Phe Leu Ala Leu Leu Val Asn Leu Ala Cys Val Glu Val Arg Leu 
305                 310                 315                 320 


Ala Leu Glu Glu Thr Gly Thr Glu Val Lys Glu Asp Val Val Thr Ala 
                325                 330                 335     


Cys Tyr Ala Leu Met Glu Leu Gly Ile Gln Glu Cys Thr Arg Cys Glu 
            340                 345                 350         


Gln Ser Leu Leu Lys Glu Pro Gln Lys Val Gln Leu Val Ser Val Met 
        355                 360                 365             


Lys Glu Ala Ile Gly Ala Val Ile His Tyr Leu Leu Gln Val Gly Ser 
    370                 375                 380                 


Glu Lys Gln Lys Glu Pro Phe Val Phe Ala Ser Val Arg Ile Leu Gly 
385                 390                 395                 400 


Ala Trp Leu Ala Glu Glu Thr Ser Ser Leu Arg Lys Glu Val Cys Gln 
                405                 410                 415     


Leu Leu Pro Phe Leu Val Arg Tyr Ala Lys Thr Leu Tyr Glu Glu Ala 
            420                 425                 430         


Glu Glu Ala Asn Asp Leu Ser Gln Gln Val Ala Asn Leu Ala Ile Ser 
        435                 440                 445             


Pro Thr Thr Pro Gly Pro Thr Trp Pro Gly Asp Ala Leu Arg Leu Leu 
    450                 455                 460                 


Leu Pro Gly Trp Cys His Leu Thr Val Glu Asp Gly Pro Arg Glu Ile 
465                 470                 475                 480 


Leu Ile Lys Glu Gly Ala Pro Ser Leu Leu Cys Lys Tyr Phe Leu Gln 
                485                 490                 495     


Gln Trp Glu Leu Thr Ser Pro Gly His Asp Thr Ser Val Leu Pro Asp 
            500                 505                 510         


Ser Val Glu Ile Gly Leu Gln Thr Cys Cys His Ile Phe Leu Asn Leu 
        515                 520                 525             


Val Val Thr Ala Pro Gly Leu Ile Lys Arg Asp Ala Cys Phe Thr Ser 
    530                 535                 540                 


Leu Met Asn Thr Leu Met Thr Ser Leu Pro Ala Leu Val Gln Gln Gln 
545                 550                 555                 560 


Gly Arg Leu Leu Leu Ala Ala Asn Val Ala Thr Leu Gly Leu Leu Met 
                565                 570                 575     


Ala Arg Leu Leu Ser Thr Ser Pro Ala Leu Gln Gly Thr Pro Ala Ser 
            580                 585                 590         


Arg Gly Phe Phe Ala Ala Ala Ile Leu Phe Leu Ser Gln Ser His Val 
        595                 600                 605             


Ala Arg Ala Thr Pro Gly Ser Asp Gln Ala Val Leu Ala Leu Ser Pro 
    610                 615                 620                 


Glu Tyr Glu Gly Ile Trp Ala Asp Leu Gln Glu Leu Trp Phe Leu Gly 
625                 630                 635                 640 


Met Gln Ala Phe Thr Gly Cys Val Pro Leu Leu Pro Trp Leu Ala Pro 
                645                 650                 655     


Ala Ala Leu Arg Ser Arg Trp Pro Gln Glu Leu Leu Gln Leu Leu Gly 
            660                 665                 670         


Ser Val Ser Pro Asn Ser Val Lys Pro Glu Met Val Ala Ala Tyr Gln 
        675                 680                 685             


Gly Val Leu Val Glu Leu Ala Arg Ala Asn Arg Leu Cys Arg Glu Ala 
    690                 695                 700                 


Met Arg Leu Gln Ala Gly Glu Glu Thr Ala Ser His Tyr Arg Met Ala 
705                 710                 715                 720 


Ala Leu Glu Gln Cys Leu Ser Glu Pro 
                725                 


<210>  5863
<211>  3685
<212>  DNA
<213>  Homosapiens

<400>  5863
gcgtgagcag cggcccgagg ctcccggagc atcgcgctgg gagaagactt cgccgctcgg     60

ggccgcagcc tggtgagctc agcccccttc gggccctccc ctgcatccca gccggggcct    120

ctccgagccg gcgctgatcg atgccgacac accccgggga ccctatcgcg actccatcgc    180

gccatatcgc gacaccatcg tgccctgtcg agactccatt ttgtcacagc ccttttcaat    240

atatatcttt ttttttttta atttgccctg tcatctttgg gggctgtctc ccatgtcgtg    300

attttgacgt gatctctccg tgacatcacc gcgccatcgt gaagtgtgat ctcatcgccg    360

ccctgtcgtg acttcatcaa tgtcgtgttg tgacctggct gcggcgggac agttgggcaa    420

ggcgagcatc atggcctcgg attgcgagcc agctctgaac caggcagagg gccgaaaccc    480

caccctggag cgctacctgg gagccctccg tgaggccaag aatgacagcg agcagtttgc    540

agccctgctg ctagtgacca aggcagtcaa agcaggtgac atagatgcca aaactcggcg    600

gcggatcttc gatgctgtcg gcttcacctt ccccaatcgt ctcctgacca ccaaggaggc    660

gccggatggc tgccctgacc atgttctgcg ggctttgggt gtggccctgc tggcctgctt    720

ctgcagtgac cctgaactgg ccgcccatcc ccaagtcctg aacaagattc ccattcttag    780

caccttcctc acagcccggg gggacccgga cgatgctgcc cgccgctcca tgattgatga    840

cacctaccag tgcctgacgg ctgtagcagg cacacccaga gggcctcggc acctcattgc    900

tggtggcacc gtgtctgccc tatgccaggc atacctgggg cacggctatg gctttgacca    960

ggccctggca ctcctggtgg ggctgctggc tgctgccgag acacagtgct ggaaggaggc   1020

ggagcccgac ctgctggccg tgttgcgggg cctcagtgag gatttccaga aagctgagga   1080

tgccagcaag tttgagctct gccagctgct gcccctcttt ttgcccccga caaccgtgcc   1140

ccctgaatgc taccgggatc tgcaggccgg gctggcacgc atcctgggaa gcaagctgag   1200

ctcctggcag cgcaaccctg cactgaagct ggcagcccgc ctggcacacg cctgcggctc   1260

cgactggatc ccggcgggca gctccgggag caagttcctg gccctgctgg tgaatctggc   1320

gtgcgtggaa gtgcggctgg cactggagga gacgggcacg gaggtgaaag aggatgtggt   1380

gaccgcctgc tatgccctca tggagttggg gatccaggaa tgcactcgct gtgagcagtc   1440

actgcttaag gagccacaga aggtgcagct cgtgagcgtc atgaaggagg ccataggggc   1500

tgttatccac tacctgctgc aggtggggtc agagaagcag aaggagccct ttgtgtttgc   1560

ctcggtgcgg atcctgggtg cctggctggc cgaggagacc tcatccttgc gtaaggaggt   1620

gtgccagctg ctgcccttcc tcgtccgcta tgccaagacc ctctacgagg aggccgagga   1680

ggccaatgac ctttcccagc aggtggccaa cctggccatc tcccccacca ccccagggcc   1740

cacctggcca ggagacgctc tccggctcct cctgcctggc tggtgccacc tgaccgttga   1800

agatgggccc cgggagatcc tgatcaagga aggggccccc tcgcttctgt gcaagtattt   1860

cctgcagcag tgggaactca catcccctgg ccacgacacc tcggtgctgc ctgacagcgt   1920

ggagattggc ctgcagacct gctgccacat cttcctcaac ctcgtggtca ccgcaccggg   1980

gctgatcaag cgtgacgcct gcttcacatc tctaatgaac accctcatga cgtcgctacc   2040

agcactagtg cagcaacagg gaaggctgct tctggctgct aatgtggcca ccctggggct   2100

cctcatggcc cggctcctta gcacctctcc agctcttcag ggaacaccag catcccgagg   2160

gttcttcgca gctgccatcc tcttcctatc acagtcccac gtggcgcggg ccaccccggg   2220

ctcagaccag gcagtgctag ccctgtcccc tgagtatgag ggcatctggg ccgacctgca   2280

ggagctctgg ttcctgggca tgcaggcctt caccggctgt gtgcctctgc tgccctggct   2340

ggcccccgct gccctgcgct cccgctggcc gcaggagctg ctccagctgc taggcagtgt   2400

cagccccaac tctgtcaagc ccgagatggt ggccgcctat cagggtgtcc tggtggagct   2460

ggcgcgggcc aaccggctgt gccgggaggc catgaggctg caggcgggcg aggagacggc   2520

cagccactac cgcatggctg ccttggagca gtgcctgtca gagccctgag gggtgtccac   2580

cggggacaga cccaggggcg ggcagagagg gaaggaggga ggaggcatct tccctgaagc   2640

ccccaatctg gcccccccct ccccagactt cctccccaaa acaccccagc tttctggctt   2700

ttctgagggc aagggcatgg tgcccacccc tcaagtgtaa ggaactgcgt tccgcccctc   2760

aggcccccat gggggcaggg atcggcttgg aaatcaacgt ggttgtcccc gccaggccgg   2820

ggaaggttgg agcagccccc agggaggggg gcactaggtg tcattgtgcc cgatgtctgg   2880

ctcccctgca ggagggaggc tccagggtaa gacagggctg gcaggagcag actgcctcag   2940

cccatgtgcc ctgccggcca gggcgtgggc tcccctcggc tgtggtgcct cctctggccc   3000

cccaggtcca cgtcctttaa attggccctt tggctcttgc ccttggctcc cttgggcaga   3060

cagcaggctt aggccattga tatcgcagtt cttcctatca gcttcagtga cccagggtct   3120

gaactgcctc catcctaggg caacctgggg cagacaggcc tggtgggggg tggggaaacc   3180

tccttccacc tgagcttgct tgaagggacc cagagtcttt gggcccagat ctttaaacct   3240

ttgtgtcgtg ttgcagcaga gtgacgatgg gggttggggg gttatttatt ttgcctgtcc   3300

ttatccctgc ttggacacct gagcatctga ttcctgtccc cctggtgcca tctggcctgg   3360

ctggagccag gaacaggagg gacacttccc cagaatccgc atgtttcccc agtgattaca   3420

ctccactgcc accgtggtgc ctggctttaa ctcccacccc tgctatgact cctctctgca   3480

gagacgcgac tggcggctcc agcagggact acctttctta taaacccagg gggaccacac   3540

acacacacac acacacacac acacacacac acacacacac acacactctt gatcccttgc   3600

ttccctcccc cagtgcgttc tgtgatcgcc aagttcaaag ctgtgcacat gtggacactc   3660

aataaatgtt cattggtgac gagaa                                         3685


<210>  5864
<211>  729
<212>  PRT
<213>  Homosapiens

<400>  5864

Met Ser Cys Cys Asp Leu Ala Ala Ala Gly Gln Leu Gly Lys Ala Ser 
1               5                   10                  15      


Ile Met Ala Ser Asp Cys Glu Pro Ala Leu Asn Gln Ala Glu Gly Arg 
            20                  25                  30          


Asn Pro Thr Leu Glu Arg Tyr Leu Gly Ala Leu Arg Glu Ala Lys Asn 
        35                  40                  45              


Asp Ser Glu Gln Phe Ala Ala Leu Leu Leu Val Thr Lys Ala Val Lys 
    50                  55                  60                  


Ala Gly Asp Ile Asp Ala Lys Thr Arg Arg Arg Ile Phe Asp Ala Val 
65                  70                  75                  80  


Gly Phe Thr Phe Pro Asn Arg Leu Leu Thr Thr Lys Glu Ala Pro Asp 
                85                  90                  95      


Gly Cys Pro Asp His Val Leu Arg Ala Leu Gly Val Ala Leu Leu Ala 
            100                 105                 110         


Cys Phe Cys Ser Asp Pro Glu Leu Ala Ala His Pro Gln Val Leu Asn 
        115                 120                 125             


Lys Ile Pro Ile Leu Ser Thr Phe Leu Thr Ala Arg Gly Asp Pro Asp 
    130                 135                 140                 


Asp Ala Ala Arg Arg Ser Met Ile Asp Asp Thr Tyr Gln Cys Leu Thr 
145                 150                 155                 160 


Ala Val Ala Gly Thr Pro Arg Gly Pro Arg His Leu Ile Ala Gly Gly 
                165                 170                 175     


Thr Val Ser Ala Leu Cys Gln Ala Tyr Leu Gly His Gly Tyr Gly Phe 
            180                 185                 190         


Asp Gln Ala Leu Ala Leu Leu Val Gly Leu Leu Ala Ala Ala Glu Thr 
        195                 200                 205             


Gln Cys Trp Lys Glu Ala Glu Pro Asp Leu Leu Ala Val Leu Arg Gly 
    210                 215                 220                 


Leu Ser Glu Asp Phe Gln Lys Ala Glu Asp Ala Ser Lys Phe Glu Leu 
225                 230                 235                 240 


Cys Gln Leu Leu Pro Leu Phe Leu Pro Pro Thr Thr Val Pro Pro Glu 
                245                 250                 255     


Cys Tyr Arg Asp Leu Gln Ala Gly Leu Ala Arg Ile Leu Gly Ser Lys 
            260                 265                 270         


Leu Ser Ser Trp Gln Arg Asn Pro Ala Leu Lys Leu Ala Ala Arg Leu 
        275                 280                 285             


Ala His Ala Cys Gly Ser Asp Trp Ile Pro Ala Gly Ser Ser Gly Ser 
    290                 295                 300                 


Lys Phe Leu Ala Leu Leu Val Asn Leu Ala Cys Val Glu Val Arg Leu 
305                 310                 315                 320 


Ala Leu Glu Glu Thr Gly Thr Glu Val Lys Glu Asp Val Val Thr Ala 
                325                 330                 335     


Cys Tyr Ala Leu Met Glu Leu Gly Ile Gln Glu Cys Thr Arg Cys Glu 
            340                 345                 350         


Gln Ser Leu Leu Lys Glu Pro Gln Lys Val Gln Leu Val Ser Val Met 
        355                 360                 365             


Lys Glu Ala Ile Gly Ala Val Ile His Tyr Leu Leu Gln Val Gly Ser 
    370                 375                 380                 


Glu Lys Gln Lys Glu Pro Phe Val Phe Ala Ser Val Arg Ile Leu Gly 
385                 390                 395                 400 


Ala Trp Leu Ala Glu Glu Thr Ser Ser Leu Arg Lys Glu Val Cys Gln 
                405                 410                 415     


Leu Leu Pro Phe Leu Val Arg Tyr Ala Lys Thr Leu Tyr Glu Glu Ala 
            420                 425                 430         


Glu Glu Ala Asn Asp Leu Ser Gln Gln Val Ala Asn Leu Ala Ile Ser 
        435                 440                 445             


Pro Thr Thr Pro Gly Pro Thr Trp Pro Gly Asp Ala Leu Arg Leu Leu 
    450                 455                 460                 


Leu Pro Gly Trp Cys His Leu Thr Val Glu Asp Gly Pro Arg Glu Ile 
465                 470                 475                 480 


Leu Ile Lys Glu Gly Ala Pro Ser Leu Leu Cys Lys Tyr Phe Leu Gln 
                485                 490                 495     


Gln Trp Glu Leu Thr Ser Pro Gly His Asp Thr Ser Val Leu Pro Asp 
            500                 505                 510         


Ser Val Glu Ile Gly Leu Gln Thr Cys Cys His Ile Phe Leu Asn Leu 
        515                 520                 525             


Val Val Thr Ala Pro Gly Leu Ile Lys Arg Asp Ala Cys Phe Thr Ser 
    530                 535                 540                 


Leu Met Asn Thr Leu Met Thr Ser Leu Pro Ala Leu Val Gln Gln Gln 
545                 550                 555                 560 


Gly Arg Leu Leu Leu Ala Ala Asn Val Ala Thr Leu Gly Leu Leu Met 
                565                 570                 575     


Ala Arg Leu Leu Ser Thr Ser Pro Ala Leu Gln Gly Thr Pro Ala Ser 
            580                 585                 590         


Arg Gly Phe Phe Ala Ala Ala Ile Leu Phe Leu Ser Gln Ser His Val 
        595                 600                 605             


Ala Arg Ala Thr Pro Gly Ser Asp Gln Ala Val Leu Ala Leu Ser Pro 
    610                 615                 620                 


Glu Tyr Glu Gly Ile Trp Ala Asp Leu Gln Glu Leu Trp Phe Leu Gly 
625                 630                 635                 640 


Met Gln Ala Phe Thr Gly Cys Val Pro Leu Leu Pro Trp Leu Ala Pro 
                645                 650                 655     


Ala Ala Leu Arg Ser Arg Trp Pro Gln Glu Leu Leu Gln Leu Leu Gly 
            660                 665                 670         


Ser Val Ser Pro Asn Ser Val Lys Pro Glu Met Val Ala Ala Tyr Gln 
        675                 680                 685             


Gly Val Leu Val Glu Leu Ala Arg Ala Asn Arg Leu Cys Arg Glu Ala 
    690                 695                 700                 


Met Arg Leu Gln Ala Gly Glu Glu Thr Ala Ser His Tyr Arg Met Ala 
705                 710                 715                 720 


Ala Leu Glu Gln Cys Leu Ser Glu Pro 
                725                 


<210>  5865
<211>  528
<212>  DNA
<213>  Homosapiens

<400>  5865
gagcatcgcg ctgggagaag acttcgccgc tcggggccgc agcctgtgtg atctcatcgc     60

cgccctgtcg tgaatcttta aacctttgtg tcgtgttgca gcagagtgac gatgggggtt    120

ggggggttat ttattttgcc tgtccttatc cctgcttgga cacctgagca tctgattcct    180

gtccccctgg tgccatctgg cctggctgga gccaggaaca ggagggacac ttccccagaa    240

tccgcatgtt tccccagtga ttacactcca ctgccaccgt ggtgcctggc tttaactccc    300

acccctgcta tgactcctct ctgcagagac gcgactggcg gctccagcag ggactacctt    360

tcttataaac ccagggggac cacacacaca cacacacaca cacacacaca cacacacaca    420

cacacacaca ctcttgatcc cttgcttccc tcccccagtg cgttctgtga tcgccaagtt    480

caaagctgtg cacatgtgga cactcaataa atgttcattg gtgacgag                 528


<210>  5866
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  5866

Met Gly Val Gly Gly Leu Phe Ile Leu Pro Val Leu Ile Pro Ala Trp 
1               5                   10                  15      


Thr Pro Glu His Leu Ile Pro Val Pro Leu Val Pro Ser Gly Leu Ala 
            20                  25                  30          


Gly Ala Arg Asn Arg Arg Asp Thr Ser Pro Glu Ser Ala Cys Phe Pro 
        35                  40                  45              


Ser Asp Tyr Thr Pro Leu Pro Pro Trp Cys Leu Ala Leu Thr Pro Thr 
    50                  55                  60                  


Pro Ala Met Thr Pro Leu Cys Arg Asp Ala Thr Gly Gly Ser Ser Arg 
65                  70                  75                  80  


Asp Tyr Leu Ser Tyr Lys Pro Arg Gly Thr Thr His Thr His Thr His 
                85                  90                  95      


Thr His Thr His Thr His Thr His Thr His Thr Leu Asp Pro Leu Leu 
            100                 105                 110         


Pro Ser Pro Ser Ala Phe Cys Asp Arg Gln Val Gln Ser Cys Ala His 
        115                 120                 125             


Val Asp Thr Gln 
    130         


<210>  5867
<211>  446
<212>  DNA
<213>  Homosapiens

<400>  5867
ggagaagact tcgccgctcg gggccgcagc ctggtgagct cagccccctt cgggccctcc     60

cctgcatccc agccggggcc tctccgagcc ggcgctgatc gatgccgaca caccccgggg    120

accctatcgc gactccatcg cgccatatcg cgacaccatc gtgccctgtc gagactccat    180

tttgtcacag cccttttcaa tatatatctt tttttttttt aatttgccct gtcatctttg    240

ggggctgtct cccatgtcgt gattttgacg tgatctctcc gtgacatcac cgcgccatcg    300

tgaagtgtga tctcatcgcc gccctgtcgt gacttcatca atgtcgtgtt gtgacctggc    360

tgcggcggga cagttgggca aggcgagcat catggcctcg gattgcgagc cagctctgaa    420

ccaggcagag ggccgaaacc ccaccc                                         446


<210>  5868
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  5868

Met Ser Cys Cys Asp Leu Ala Ala Ala Gly Gln Leu Gly Lys Ala Ser 
1               5                   10                  15      


Ile Met Ala Ser Asp Cys Glu Pro Ala Leu Asn Gln Ala Glu Gly Arg 
            20                  25                  30          


Asn Pro 
        


<210>  5869
<211>  946
<212>  DNA
<213>  Homosapiens

<400>  5869
cttcgggccc tcccctgcat cccagccggg gcctctccga gccggcgctg atcgatgccg     60

acacaccccg gggaccctat cgcgactcca tcgcgccata tcgcgacacc atcgtgccct    120

gtcgagactc cattttgtca cagccctttt caatatatat cttttttttt tttaatttgc    180

cctgtcatct ttgggggctg tctcccatgt cgtgattttg acgtgatctc tccgtgacat    240

caccgcgcca tcgtgaagtg tgatctcatc gccgccctgt cgtgacttca tcaatgtcgt    300

gttgtgacct ggctgcggcg ggacaggtgg tgaccgccag gaaccctcct ccccttctca    360

tctccccatc tcagcagccc tgcttcgatt atccggcttt tggattctcc gttgtcctgg    420

gaactatccg ggaccccctc ttgcttctcc agcccctgcc ggcatccaca ggctggtagc    480

gggacgggga gggcgagaag agggagcgca aggggttaat tctgctgctg ccgccgccgc    540

tgctgctgct gctgcagcct ctacccgagg gagggaaagg agaggagttg ggcaaggcga    600

gcatcatggc ctcggattgc gagccagctc tgaaccaggc agagggccga aaccccaccc    660

tggagcgcta cctgggagcc ggctccgact ggatcccggc gggcagctcc gggagcaagt    720

tcctggccct gctggtgaat ctggcgtgcg tggaagtgcg gctggcactg gaggagacgg    780

gcacggaggt gaaagaggat gtggtgaccg cctgctatgc cctcatggag ttggggatcc    840

aggaatgcac tcgctgtgag cagtcactgc ttaaggagcc acagaaggtg cagctcgtga    900

gcgtcatgaa ggaggccata ggggctgtta tccactacct gctgca                   946


<210>  5870
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  5870

Met Ala Ser Asp Cys Glu Pro Ala Leu Asn Gln Ala Glu Gly Arg Asn 
1               5                   10                  15      


Pro Thr Leu Glu Arg Tyr Leu Gly Ala Gly Ser Asp Trp Ile Pro Ala 
            20                  25                  30          


Gly Ser Ser Gly Ser Lys Phe Leu Ala Leu Leu Val Asn Leu Ala Cys 
        35                  40                  45              


Val Glu Val Arg Leu Ala Leu Glu Glu Thr Gly Thr Glu Val Lys Glu 
    50                  55                  60                  


Asp Val Val Thr Ala Cys Tyr Ala Leu Met Glu Leu Gly Ile Gln Glu 
65                  70                  75                  80  


Cys Thr Arg Cys Glu Gln Ser Leu Leu Lys Glu Pro Gln Lys Val Gln 
                85                  90                  95      


Leu Val Ser Val Met Lys Glu Ala Ile Gly Ala Val Ile His Tyr Leu 
            100                 105                 110         


<210>  5871
<211>  1062
<212>  DNA
<213>  Homosapiens

<400>  5871
gaccaaggca gtcaaagcag gtgacataga tgccaaaact cggcggcgga tcttcgatgc     60

tgtcggcttc accttcccca atcgtctcct gaccaccaag gaggcgccgg atggctgccc    120

tgaccatgtt ctgcgggctt tgggtgtggc cctgctggcc tgcttctgca gtgaccctga    180

actggccgcc catccccaag tcctgaacaa gacccccagg gaggggggca ctaggtgtca    240

ttgtgcccga tgtctggctc ccctgcagga gggaggctcc agggtaagac agggctggca    300

ggagcagact gcctcagccc atgtgccctg ccggccaggg cgtgggctcc cctcggctgt    360

ggtgcctcct ctggcccccc aggtccacgt cctttaaatt ggccctttgg ctcttgccct    420

tggctccctt gggcagacag caggcttagg ccattgatat cgcagttctt cctatcagct    480

tcagtgaccc agggtctgaa ctgcctccat cctagggcaa cctggggcag acaggcctgg    540

tggggggtgg ggaaacctcc ttccacctga gcttgcttga agggacccag agtctttggg    600

cccagatctt taaacctttg tgtcgtgttg cagcagagtg acgatggggg ttggggggtt    660

atttattttg cctgtcctta tccctgcttg gacacctgag catctgattc ctgtccccct    720

ggtgccatct ggcctggctg gagccaggaa caggagggac acttccccag aatccgcatg    780

tttccccagt gattacactc cactgccacc gtggtgcctg gctttaactc ccacccctgc    840

tatgactcct ctctgcagag acgcgactgg cggctccagc agggactacc tttcttataa    900

acccaggggg accacacaca cacacacaca cacacacaca cacacacaca cacacacaca    960

cactcttgat cccttgcttc cctcccccag tgcgttctgt gatcgccaag ttcaaagctg   1020

tgcacatgtg gacactcaat aaatgttcat tggtgacgag aa                      1062


<210>  5872
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  5872

Met Gly Val Gly Gly Leu Phe Ile Leu Pro Val Leu Ile Pro Ala Trp 
1               5                   10                  15      


Thr Pro Glu His Leu Ile Pro Val Pro Leu Val Pro Ser Gly Leu Ala 
            20                  25                  30          


Gly Ala Arg Asn Arg Arg Asp Thr Ser Pro Glu Ser Ala Cys Phe Pro 
        35                  40                  45              


Ser Asp Tyr Thr Pro Leu Pro Pro Trp Cys Leu Ala Leu Thr Pro Thr 
    50                  55                  60                  


Pro Ala Met Thr Pro Leu Cys Arg Asp Ala Thr Gly Gly Ser Ser Arg 
65                  70                  75                  80  


Asp Tyr Leu Ser Tyr Lys Pro Arg Gly Thr Thr His Thr His Thr His 
                85                  90                  95      


Thr His Thr His Thr His Thr His Thr His Thr Leu Asp Pro Leu Leu 
            100                 105                 110         


Pro Ser Pro Ser Ala Phe Cys Asp Arg Gln Val Gln Ser Cys Ala His 
        115                 120                 125             


Val Asp Thr Gln 
    130         


<210>  5873
<211>  1073
<212>  DNA
<213>  Homosapiens

<400>  5873
cgggaggcca tgaggctgca ggcgggcgag gagacggcca gccactaccg catggctgcc     60

ttggagcagt gcctgtcaga gccctgaggg gtgtccaccg gggacagacc caggggcggg    120

cagagaggga aggagggagg aggcatcttc cctgaagccc ccaatctggc ccccccctcc    180

ccagacttcc tccccaaaac accccagctt tctggctttt ctgagggcaa gggcatggtg    240

cccacccctc aagtgtaagg aactgcgttc cgcccctcag gcccccatgg gggcagggat    300

cggcttggaa atcaacgtgg ttgtccccgc caggccgggg aaggttggag cagcccccag    360

ggaggggggc actaggtgtc attgtgcccg atgtctggct cccctgcagg agggaggctc    420

cagggtaaga cagggctggc aggagcagac tgcctcagcc catgtgccct gccggccagg    480

gcgtgggctc ccctcggctg tggtgcctcc tctggccccc caggtccacg tcctttaaat    540

tggccctttg gctcttgccc ttggctccct tgggcagaca gcaggcttag gccattgata    600

tcgcagttct tcctatcagc ttcagtgacc cagggtctga actgcctcca tcctagggca    660

acctggggca gacaggcctg gtggggggtg gggaaacctc cttccacctg agcttgcttg    720

aagggaccca gagtctttgg gcccagatct ttaaaccttt gtgtcgtgtt gcagcagagt    780

gacgatgggg gttggggggt tatttatttt gcctgtcctt atccctgctt ggacacctga    840

gcatctgatt cccctgctat gactcctctc tgcagagacg cgactggcgg ctccagcagg    900

gactaccttt cttataaacc cagggggacc acacacacac acacacacac acacacacac    960

acacacacac acacacacac tcttgatccc ttgcttccct cccccagtgc gttctgtgat   1020

cgccaagttc aaagctgtgc acatgtggac actcaataaa tgttcattgg tga          1073


<210>  5874
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  5874

Met Ser Gly Ser Pro Ala Gly Gly Arg Leu Gln Gly Lys Thr Gly Leu 
1               5                   10                  15      


Ala Gly Ala Asp Cys Leu Ser Pro Cys Ala Leu Pro Ala Arg Ala Trp 
            20                  25                  30          


Ala Pro Leu Gly Cys Gly Ala Ser Ser Gly Pro Pro Gly Pro Arg Pro 
        35                  40                  45              


Leu Asn Trp Pro Phe Gly Ser Cys Pro Trp Leu Pro Trp Ala Asp Ser 
    50                  55                  60                  


Arg Leu Arg Pro Leu Ile Ser Gln Phe Phe Leu Ser Ala Ser Val Thr 
65                  70                  75                  80  


Gln Gly Leu Asn Cys Leu His Pro Arg Ala Thr Trp Gly Arg Gln Ala 
                85                  90                  95      


Trp Trp Gly Val Gly Lys Pro Pro Ser Thr 
            100                 105     


<210>  5875
<211>  283
<212>  DNA
<213>  Homosapiens

<400>  5875
gcgcatcgcg ttctcagctg gcgaagtccc tgcggccccc tccctccgag atttcgttag     60

cgcgggacag gagggttgga aagtccagca ctcaggcgcc ccgatccccc ggccgaatat    120

gtcccgggcc cgagactact caccatggcg gagtaggtgt gcaccagcat ggggcggaac    180

tgcttcacaa gattaaagga gaaacagaaa atgtatctag cgctgtgctt ggggcatggc    240

aggaactcaa tgaatgctta ttaaatactg taaatgataa aca                      283


<210>  5876
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  5876

Met Gly Arg Asn Cys Phe Thr Arg Leu Lys Glu Lys Gln Lys Met Tyr 
1               5                   10                  15      


Leu Ala Leu Cys Leu Gly His Gly Arg Asn Ser Met Asn Ala Tyr 
            20                  25                  30      


<210>  5877
<211>  851
<212>  DNA
<213>  Homosapiens

<400>  5877
gggccctgcg agctccaggt gcctctgccc cgcggcgctg gcgaagtcga agcccgagaa     60

cgcccaccgc agcgatgcga aggccgcttc tggggtgggg ctgaggctgc agctgcctcc    120

ctttcgcacc aaggacccca accttcagcg acgcagccgc cgctcccgcc caggctggga    180

ggcactgtag ggatccgacg cttcaggtgg ccaaagagcg actttctctg attccagggc    240

cctggcgggg caggctccag taccgcactc ggcggaggcc gaaggtctgt ggggcaggac    300

aggagttcct cgtgccgtcg gaagggccga ggacgaagga gggcgctaat tcactcccca    360

ctgggctggc ggcaacgccg aatcccgcag tgaccgcgga gggccaaggt gcaggctgcc    420

ccatggatgc cacacgtggc agcggggaga aaagaagtga ttcggtccct gccgagggtt    480

gctgccaccc acgcactgct ggcggactca gtgccaggca gccttgatgg ccaggcaacg    540

tctaacccag gaggtgggac acatcctcgg agtcaccagt gagatgtggc gagctgggag    600

aaaagtcggc ttcctgcatt tgtcaccttc tgcctccagc catggtagta aaccaccgcg    660

gccagtcccg acccatcccg gatccctcgg gtctcacctg caggtcctcc agaccggggg    720

ccgccgccag ccccggaagg ccgagaggaa ctgcttcaca agattaaagg agaaacagaa    780

aatgtatcta gcgctgtgct tggggcatgg caggaactca atgaatgctt attaaatact    840

gtaaatgata a                                                         851


<210>  5878
<211>  102
<212>  PRT
<213>  Homosapiens

<400>  5878

Met Ala Arg Gln Arg Leu Thr Gln Glu Val Gly His Ile Leu Gly Val 
1               5                   10                  15      


Thr Ser Glu Met Trp Arg Ala Gly Arg Lys Val Gly Phe Leu His Leu 
            20                  25                  30          


Ser Pro Ser Ala Ser Ser His Gly Ser Lys Pro Pro Arg Pro Val Pro 
        35                  40                  45              


Thr His Pro Gly Ser Leu Gly Ser His Leu Gln Val Leu Gln Thr Gly 
    50                  55                  60                  


Gly Arg Arg Gln Pro Arg Lys Ala Glu Arg Asn Cys Phe Thr Arg Leu 
65                  70                  75                  80  


Lys Glu Lys Gln Lys Met Tyr Leu Ala Leu Cys Leu Gly His Gly Arg 
                85                  90                  95      


Asn Ser Met Asn Ala Tyr 
            100         


<210>  5879
<211>  2185
<212>  DNA
<213>  Homosapiens

<400>  5879
gtgcccgtcc gtcctgcctc catggacccg cccgggaacg gccaccgctg aggaccccac     60

gcccactagg atcccggctg ggtcgcaccc agctaccgca ccgtgacctc cgcgggctgt    120

gccggctccc ggcgcctctg cccgcagcgc tcgccgtcgg gctagggctc cgccgccgcc    180

acgcctcgcg cccggcactc accgccccat gctggtgcac acctactccg ccatggagcg    240

ccccgacggg ctgggagcag ctgccggcgg ggcccgcctg tcgtctctgc cccaggcggc    300

ctacgggccg gcgcccccgc tctgccacac gccggccgcc acagctgccg ccgaattcca    360

gccgccctac ttcccgccgc cctacccgca gccaccgctg ccctacggtc aggcgcccga    420

cgccgccgca gcctttcccc acctggcagg ggacccatat ggcggcctgg cgcccctggc    480

gcagccgcag cctcctcagg ccgcctgggc cgcgccccgc gcagccgccc gcgcccacga    540

ggagcctccc ggcctgctgg caccgcccgc ccgcgccctg ggccttgacc cgcgccgtga    600

ctatgccact gccgtgcccc ggctcctgca cggcctggcc gacggcgcgc acggcctggc    660

agacgcacct ctcggccttc cggggctggc ggcggccccc ggtctggagg acctgcaggc    720

aatggacgag ccgggaatga gcctcctaga ccagtccgtg atcaagaaag tgcccatccc    780

ctccaaagcc agcagcctct cagccctctc cttggccaaa gacagcctgg tgggcggcat    840

cacaaatcct ggtgaggtct tctgctccgt gcccggccgg ctttcactgc tcagctcaac    900

gtccaagtac aaggtgacgg tgggggaggt gcagcggcga ctctcgcctc ccgagtgcct    960

caacgcctcc ctcctggggg gtgtcctccg cagggccaag tccaaaaatg ggggccggtg   1020

tttgcgggaa cggttagaga agattgggct caacctgcca gctggccgtc gcaaggccgc   1080

caatgtgacg ctgctgactt cgctagtgga aggagaggcc gtgcacctgg cccgagactt   1140

cggttacgtc tgtgagacgg agttcccagc caaggcagct gccgagtacc tgtgccgaca   1200

gcacgctgac ccgggggagc tgcacagccg caagagcatg ctgctggctg ccaagcagat   1260

ctgcaaggag tttgcagact tgatggctca ggaccgctca ccgctgggca acagccgccc   1320

agcactcatc ctggagcccg gagtacagag ctgcttgaca cactttagcc tcatcaccca   1380

tggcttcggt gggcctgcca tctgtgctgc cctcactgcc ttccagaact atttgctgga   1440

gtcactcaag gggctggaca agatgtttct aagcagtgtg ggcagtgggc atggtgaaac   1500

caaggcttcg gagaaggatg ccaagcatcg gaaataactg cttctcccac cccatcccta   1560

aggggctccc aggccctgaa atagggactt agctcttggg ggtgggcctg gaaggactga   1620

aaggtgggat tagagtcagg ccagaaagag aacattcatc cagagatccc agagttgggg   1680

atctggcttg gagtaaggga gggtggcctc tctgtggtgg tgtgttggta agttaagggc   1740

ccaggtattt gtctcatgtg tgcaattttc tgacctttga tggttgagaa gggtttggac   1800

agaaaattga catgaaaaga tctggctcat ggggcagagc cctttccatt agcgtggctg   1860

ggtggccgtg ggtgcttcta gaggccaaag cctttgtgtt tttcactggt ggcaggagga   1920

aaattgataa atcagaggtg ctactgagga gttggtgccc ctcattccag aatctcctac   1980

ccccagaaaa ggggtgctgg aaggaggccc cagtggactc tttgtaccct tcctactctc   2040

agagagaagt gggcaggagg ggtcctcaag gaacaaagaa gataaagcac aaatcgcaga   2100

acttgaatcc aggctgctgc tcatcatagt cctgttgctg tctgtcctat ttatttatgt   2160

atgttgtaat taaatttgaa atttt                                         2185


<210>  5880
<211>  442
<212>  PRT
<213>  Homosapiens

<400>  5880

Met Leu Val His Thr Tyr Ser Ala Met Glu Arg Pro Asp Gly Leu Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gly Ala Arg Leu Ser Ser Leu Pro Gln Ala Ala Tyr 
            20                  25                  30          


Gly Pro Ala Pro Pro Leu Cys His Thr Pro Ala Ala Thr Ala Ala Ala 
        35                  40                  45              


Glu Phe Gln Pro Pro Tyr Phe Pro Pro Pro Tyr Pro Gln Pro Pro Leu 
    50                  55                  60                  


Pro Tyr Gly Gln Ala Pro Asp Ala Ala Ala Ala Phe Pro His Leu Ala 
65                  70                  75                  80  


Gly Asp Pro Tyr Gly Gly Leu Ala Pro Leu Ala Gln Pro Gln Pro Pro 
                85                  90                  95      


Gln Ala Ala Trp Ala Ala Pro Arg Ala Ala Ala Arg Ala His Glu Glu 
            100                 105                 110         


Pro Pro Gly Leu Leu Ala Pro Pro Ala Arg Ala Leu Gly Leu Asp Pro 
        115                 120                 125             


Arg Arg Asp Tyr Ala Thr Ala Val Pro Arg Leu Leu His Gly Leu Ala 
    130                 135                 140                 


Asp Gly Ala His Gly Leu Ala Asp Ala Pro Leu Gly Leu Pro Gly Leu 
145                 150                 155                 160 


Ala Ala Ala Pro Gly Leu Glu Asp Leu Gln Ala Met Asp Glu Pro Gly 
                165                 170                 175     


Met Ser Leu Leu Asp Gln Ser Val Ile Lys Lys Val Pro Ile Pro Ser 
            180                 185                 190         


Lys Ala Ser Ser Leu Ser Ala Leu Ser Leu Ala Lys Asp Ser Leu Val 
        195                 200                 205             


Gly Gly Ile Thr Asn Pro Gly Glu Val Phe Cys Ser Val Pro Gly Arg 
    210                 215                 220                 


Leu Ser Leu Leu Ser Ser Thr Ser Lys Tyr Lys Val Thr Val Gly Glu 
225                 230                 235                 240 


Val Gln Arg Arg Leu Ser Pro Pro Glu Cys Leu Asn Ala Ser Leu Leu 
                245                 250                 255     


Gly Gly Val Leu Arg Arg Ala Lys Ser Lys Asn Gly Gly Arg Cys Leu 
            260                 265                 270         


Arg Glu Arg Leu Glu Lys Ile Gly Leu Asn Leu Pro Ala Gly Arg Arg 
        275                 280                 285             


Lys Ala Ala Asn Val Thr Leu Leu Thr Ser Leu Val Glu Gly Glu Ala 
    290                 295                 300                 


Val His Leu Ala Arg Asp Phe Gly Tyr Val Cys Glu Thr Glu Phe Pro 
305                 310                 315                 320 


Ala Lys Ala Ala Ala Glu Tyr Leu Cys Arg Gln His Ala Asp Pro Gly 
                325                 330                 335     


Glu Leu His Ser Arg Lys Ser Met Leu Leu Ala Ala Lys Gln Ile Cys 
            340                 345                 350         


Lys Glu Phe Ala Asp Leu Met Ala Gln Asp Arg Ser Pro Leu Gly Asn 
        355                 360                 365             


Ser Arg Pro Ala Leu Ile Leu Glu Pro Gly Val Gln Ser Cys Leu Thr 
    370                 375                 380                 


His Phe Ser Leu Ile Thr His Gly Phe Gly Gly Pro Ala Ile Cys Ala 
385                 390                 395                 400 


Ala Leu Thr Ala Phe Gln Asn Tyr Leu Leu Glu Ser Leu Lys Gly Leu 
                405                 410                 415     


Asp Lys Met Phe Leu Ser Ser Val Gly Ser Gly His Gly Glu Thr Lys 
            420                 425                 430         


Ala Ser Glu Lys Asp Ala Lys His Arg Lys 
        435                 440         


<210>  5881
<211>  437
<212>  DNA
<213>  Homosapiens

<400>  5881
gaacgaggtg agccccgtcc tggctaggtt tctccagcca cagtatgagc agcctcagag     60

gtctctccat ttggcagtcc caggagtctg tgcttcctct tctgccttgg gcacttgagg    120

aaagcctcaa aggcaggagg gtggagttgt cagtttgaag gactgtgtta ggtgggagga    180

ctggatgttc taagccggaa acaaacccaa ggatgtgagg acagggttgg cagaagtggg    240

tggagtttgt gtgggccaga ctgtggggcc ctcaaaagag tttgaacttt agcctaccaa    300

ctggtagttc tcagatttat ctctctcttt tctttttttt ccgagacaag gtcttgcact    360

gcactccggc ctgggcaaca gaacaagatt ctgtctcaat aaataaataa ataaaaattt    420

ctgttgttta taagcta                                                   437


<210>  5882
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  5882

Met Ser Ser Leu Arg Gly Leu Ser Ile Trp Gln Ser Gln Glu Ser Val 
1               5                   10                  15      


Leu Pro Leu Leu Pro Trp Ala Leu Glu Glu Ser Leu Lys Gly Arg Arg 
            20                  25                  30          


Val Glu Leu Ser Val 
        35          


<210>  5883
<211>  2641
<212>  DNA
<213>  Homosapiens

<400>  5883
ggggagattt taccgagcaa cgtagggaaa cggctgcctg gctacctacc cctttttgac     60

acccacacgt gctcggcacc ttacatacac tgcgtgattt tatcctaaag ccacttttaa    120

aatcttagtg tgtaaacaga gaaactgggc gtcacataag gcaagtgacc tgcacagcct    180

gctccggagg agacccgtac gatcccagag acaagcactg aacataaggc acccggcgcc    240

gcgcccgctt tgcaacctct cgcgacagtt gtacgtcatc cgagagcgcc gtggaagtcg    300

tgctgcaggc gtcgcgccaa tcttcgctct gaggtgctgt ctcaccggtg agacctggaa    360

gcgggcgagt ctcgtgctgt gtcggacctg cagcccctgg ccttccgcca ccatggagta    420

cctcatcggt atccaaggcc ccgactatgt tcttgtcgcc tccgaccggg tggccgccag    480

caatattgtc cagatgaagg acgatcatga caagatgttt aagatgagtg aaaagatatt    540

actcctgtgt gttggagagg ctggagacac tgtacagttt gcagaatata ttcagaaaaa    600

cgtgcaactt tataagatgc gaaatggata tgaattgtct cccacggcag cagctaactt    660

cacacgccga aacctggctg actgtcttcg gagtcggacc ccatatcatg tgaacctccg    720

cctcccgggc ccaagtgatc ctcccatctc agcctcctga gtagctagga ttacaggcgc    780

acaccaccaa tgcccagcta gtttttgtgt ttttcataga gacagggtct caccatgtca    840

ttcaggttgg tcttgaactc ctgggctcaa gcagtctgcc tgccttggct tcccagtgct    900

gggattacag gcgtgagcca ccgtgcccgg ctaaaaagta tttttaagtt ctgcatattg    960

cttatttcac ttaacactat attagagatt gttttatatc aatacatata gatatgctta   1020

ttcttgttga cagttgcata attttccatt aaattgatgt atcatgggca gttaaccagt   1080

tactcgtttt actcttagca taactttagg gaacaatgtg gatgttttgt ggttaaagct   1140

attaaaacag tggttcttga ccagatgtgt gtttcagaat gttcatctca catttccagt   1200

tgctactgat gctgctggtc taggaaccac atatcaaaac catttggtct ccgactaaga   1260

taaaccctac tttatccaat tctgtgctcc tcttaatatc atatacagat aggtttttgt   1320

tttgtctgtg attaaatgta tcatctaaga tactacctac tgatcataac gttcatatta   1380

aagtattggg ttaacattag atttgggtgt cttatacact atttaatacg ccaatgataa   1440

atgccttaca ccataagaag aaagctaatc attgagtaaa tgggagaaaa gagatgattc   1500

acgtcactac agttgattca acctccaaca ccaccatgaa tatgcatagg tttgagcttt   1560

tagctagatt cctgagtgta aggcatctat tttaaaagtg ccacaggttg gccgggtgcg   1620

gtggctcatg cctgtaatcc cagcactttg gccgcccgcc gaggcgggcg gatcacctga   1680

ggtcaggagt tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaaaat   1740

atataacaat tagccaggcg tggtggcaca cgcctgtaaa cccaactact tgggaggctg   1800

aggcaggaga attgcttgag cccgggagag ggaggttgca gtgagccgag atcatgccac   1860

tgcactccag cctggctgac agagcaagac tctgtctcaa aaaaaaaaaa aaaaaaaaaa   1920

aaaaagcgcc acagatgatt ctgacgccct acccagtgga gtgctgctac taaagcacag   1980

actatcctgc tacatgattt tcccatctgt acaatgactg aaatagcacc tattctatgt   2040

ggtagatatg agaattccat gaagtaatat aggtaaacat ttagttcagg gcttggcatg   2100

tggtaagtgc tcagtaagtg tataatgatt ggtaaacttg ttattctgca ttcaggcctc   2160

accagggatg acatacggtt ctctgccttt gaatgtaagt gtccccaggg caatctcagg   2220

caagcctgca aacccatcct gactctcagt gtttttttgc caatctggat ctctttcctg   2280

agctccaaat caactcattc ctagatagct caccctccag atttagggac atcgaactca   2340

gtatgtctaa agctgagcct taccatctgc ccctctccaa accgcctcta tgacattctg   2400

tcttagagaa ttagagctac ctggtttccc aagtgcccaa gtcagaaacc caggcatcat   2460

ttatttttaa taaatgtttt attttggaat aaatttggtt ttacagaaaa gttgcaaaga   2520

taatatggtg tccttatacc ccttattcag tttctgtaat gttaacatct tctatatacc   2580

acagtatgtt tgtcaaaact gagaaaccaa cattggttgg tgtattagta ttactaagct   2640

c                                                                   2641


<210>  5884
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  5884

Met Glu Tyr Leu Ile Gly Ile Gln Gly Pro Asp Tyr Val Leu Val Ala 
1               5                   10                  15      


Ser Asp Arg Val Ala Ala Ser Asn Ile Val Gln Met Lys Asp Asp His 
            20                  25                  30          


Asp Lys Met Phe Lys Met Ser Glu Lys Ile Leu Leu Leu Cys Val Gly 
        35                  40                  45              


Glu Ala Gly Asp Thr Val Gln Phe Ala Glu Tyr Ile Gln Lys Asn Val 
    50                  55                  60                  


Gln Leu Tyr Lys Met Arg Asn Gly Tyr Glu Leu Ser Pro Thr Ala Ala 
65                  70                  75                  80  


Ala Asn Phe Thr Arg Arg Asn Leu Ala Asp Cys Leu Arg Ser Arg Thr 
                85                  90                  95      


Pro Tyr His Val Asn Leu Arg Leu Pro Gly Pro Ser Asp Pro Pro Ile 
            100                 105                 110         


Ser Ala Ser 
        115 


<210>  5885
<211>  1398
<212>  DNA
<213>  Homosapiens

<400>  5885
ggggagattt taccgagcaa cgtagggaaa cggctgcctg gctacctacc cctttttgac     60

acccacacgt gctcggcacc ttacatacac tgcgtgattt tatcctaaag ccacttttaa    120

aatcttagtg tgtaaacaga gaaactgggc gtcacataag gcaagtgacc tgcacagcct    180

gctccggagg agacccgtac gatcccagag acaagcactg aacataaggc acccggcgcc    240

gcgcccgctt tgcaacctct cgcgacagtt gtacgtcatc cgagagcgcc gtggaagtcg    300

tgctgcaggc gtcgcgccaa tcttcgctct gaggtgctgt ctcaccggtg agacctggaa    360

gcgggcgagt ctcgtgctgt gtcggacctg cagcccctgg ccttccgcca ccatggagta    420

cctcatcggt atccaaggcc ccgactatgt tcttgtcgcc tccgaccggg tggccgccag    480

caatattgtc cagatgaagg acgatcatga caagatgttt aagatgagtg aaaagatatt    540

actcctgtgt gttggagagg ctggagacac tgtacagttt gcagaatata ttcagaaaaa    600

cgtgcaactt tataagatgc gaaatggata tgaattgtct cccacggcag cagctaactt    660

cacacgccga aacctggctg actgtcttcg gagtcggacc ccatatcatg tgaacctccg    720

cctcccgggc ccaagtgatc ctcccatctc agcctcctga gtagctagga ttacaggcgc    780

acaccaccaa tgcccagcta gtttttgtgt ttttcataga gacagggtct caccatgtca    840

ttcaggttgg tcttgaactc ctgggctcaa gcagtctgcc tgccttggct tcccagtgct    900

gggattacag gcgtgagcca ccgtgcccgg ctaaaaagta tttttaagtt ctgcatattg    960

cttatttcac ttaacactat attagagatt gttttatatc aatacatata gatatgctta   1020

ttcttgttga cagttgcata attttccatt aaattgatgt atcatgggca gttaaccagt   1080

tactcgtttt actcttagca taactttagg gaacaatgtg gatgttttgt ggttaaagct   1140

attaaaacag tggttcttga ccagatgtgt gtttcagaat gttcatctca catttccagt   1200

tgctactgat gctgctggtc taggaaccac atatcaaaac catttggtct ccgactaaga   1260

taaaccctac tttatccaat tctgtgctcc tcttaatatc atatacagat aggtttttgt   1320

tttgtctgtg attaaatgta tcatctaaga tactacctac tgatcataac gttcatatta   1380

aagtattggg ttaacatt                                                 1398


<210>  5886
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  5886

Met Glu Tyr Leu Ile Gly Ile Gln Gly Pro Asp Tyr Val Leu Val Ala 
1               5                   10                  15      


Ser Asp Arg Val Ala Ala Ser Asn Ile Val Gln Met Lys Asp Asp His 
            20                  25                  30          


Asp Lys Met Phe Lys Met Ser Glu Lys Ile Leu Leu Leu Cys Val Gly 
        35                  40                  45              


Glu Ala Gly Asp Thr Val Gln Phe Ala Glu Tyr Ile Gln Lys Asn Val 
    50                  55                  60                  


Gln Leu Tyr Lys Met Arg Asn Gly Tyr Glu Leu Ser Pro Thr Ala Ala 
65                  70                  75                  80  


Ala Asn Phe Thr Arg Arg Asn Leu Ala Asp Cys Leu Arg Ser Arg Thr 
                85                  90                  95      


Pro Tyr His Val Asn Leu Arg Leu Pro Gly Pro Ser Asp Pro Pro Ile 
            100                 105                 110         


Ser Ala Ser 
        115 


<210>  5887
<211>  722
<212>  DNA
<213>  Homosapiens

<400>  5887
gctgcaggcg tcgcgccaat cttcgctctg aggtgctgtc tcaccggtga gacctggaag     60

cgggcgagtc tcgtgctgtg tcggacctgc agcccctggc cttccgccac catggagtac    120

ctcatcggta tccaaggccc cgactatgtt cttgtcgcct ccgaccgggt ggccgccagc    180

aatattgtcc agatgaagga cggatatgaa ttgtctccca cggcagcagc taacttcaca    240

cgccgaaacc tggctgactg tcttcggagt cggaccccat atcatgtgaa cctcctcctg    300

gctggctatg atgagcatga agggccagcg ctgtattaca tggactacct ggcagccttg    360

gccaaggccc cttttgcagc ccacggctat ggtgccttcc tgactctcag tatcctcgac    420

cgatactaca caccgactat ctcacgtgag agggcagtgg aactccttag gaaatgtctg    480

gaggagctcc agaaacgctt catcctgaat ctgccaacct tcagtgttcg aatcattgac    540

aaaaatggca tccatgacct ggataacatt tccttcccca aacagggctc ctaacatcat    600

gtcctccctc ccacttgcca gggaactttt ttttgatggg ctcctttatt tttttctact    660

cttttcaggc gcactcttga taaatggtta attcagaata aaggtgacta tggatataat    720

tg                                                                   722


<210>  5888
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  5888

Met Glu Tyr Leu Ile Gly Ile Gln Gly Pro Asp Tyr Val Leu Val Ala 
1               5                   10                  15      


Ser Asp Arg Val Ala Ala Ser Asn Ile Val Gln Met Lys Asp Gly Tyr 
            20                  25                  30          


Glu Leu Ser Pro Thr Ala Ala Ala Asn Phe Thr Arg Arg Asn Leu Ala 
        35                  40                  45              


Asp Cys Leu Arg Ser Arg Thr Pro Tyr His Val Asn Leu Leu Leu Ala 
    50                  55                  60                  


Gly Tyr Asp Glu His Glu Gly Pro Ala Leu Tyr Tyr Met Asp Tyr Leu 
65                  70                  75                  80  


Ala Ala Leu Ala Lys Ala Pro Phe Ala Ala His Gly Tyr Gly Ala Phe 
                85                  90                  95      


Leu Thr Leu Ser Ile Leu Asp Arg Tyr Tyr Thr Pro Thr Ile Ser Arg 
            100                 105                 110         


Glu Arg Ala Val Glu Leu Leu Arg Lys Cys Leu Glu Glu Leu Gln Lys 
        115                 120                 125             


Arg Phe Ile Leu Asn Leu Pro Thr Phe Ser Val Arg Ile Ile Asp Lys 
    130                 135                 140                 


Asn Gly Ile His Asp Leu Asp Asn Ile Ser Phe Pro Lys Gln Gly Ser 
145                 150                 155                 160 


<210>  5889
<211>  778
<212>  DNA
<213>  Homosapiens

<400>  5889
gaagtcgtgc tgcaggcgtc gcgccaatct tcgctctgag gtgctgtctc accggtgaga     60

cctggaagcg ggcgagtctc gtgctgtgtc ggacctgcag cccctggcct tccgccacca    120

tggagtacct catcgatcat gacaagatgt ttaagatgag tgaaaagata ttactcctgt    180

gtgttggaga ggctggagac actgtacagt ttgcagaata tattcagaaa aacgtgcaac    240

tttataagat gcgaaatgga tatgaattgt ctcccacggc agcagctaac ttcacacgcc    300

gaaacctggc tgactgtctt cggagtcgga ccccatatca tgtgaacctc ctcctggctg    360

gctatgatga gcatgaaggg ccagcgctgt attacatgga ctacctggca gccttggcca    420

aggccccttt tgcagcccac ggctatggtg ccttcctgac tctcagtatc ctcgaccgat    480

actacacacc gactatctca cgtgagaggg cagtggaact ccttaggaaa tgtctggagg    540

agctccagaa acgcttcatc ctgaatctgc caaccttcag tgttcgaatc attgacaaaa    600

atggcatcca tgacctggat aacatttcct tccccaaaca gggctcctaa catcatgtcc    660

tccctcccac ttgccaggga actttttttt gatgggctcc tttatttttt tctactcttt    720

tcaggcgcac tcttgataaa tggttaattc agaataaagg tgactatgga tataattg      778


<210>  5890
<211>  176
<212>  PRT
<213>  Homosapiens

<400>  5890

Met Glu Tyr Leu Ile Asp His Asp Lys Met Phe Lys Met Ser Glu Lys 
1               5                   10                  15      


Ile Leu Leu Leu Cys Val Gly Glu Ala Gly Asp Thr Val Gln Phe Ala 
            20                  25                  30          


Glu Tyr Ile Gln Lys Asn Val Gln Leu Tyr Lys Met Arg Asn Gly Tyr 
        35                  40                  45              


Glu Leu Ser Pro Thr Ala Ala Ala Asn Phe Thr Arg Arg Asn Leu Ala 
    50                  55                  60                  


Asp Cys Leu Arg Ser Arg Thr Pro Tyr His Val Asn Leu Leu Leu Ala 
65                  70                  75                  80  


Gly Tyr Asp Glu His Glu Gly Pro Ala Leu Tyr Tyr Met Asp Tyr Leu 
                85                  90                  95      


Ala Ala Leu Ala Lys Ala Pro Phe Ala Ala His Gly Tyr Gly Ala Phe 
            100                 105                 110         


Leu Thr Leu Ser Ile Leu Asp Arg Tyr Tyr Thr Pro Thr Ile Ser Arg 
        115                 120                 125             


Glu Arg Ala Val Glu Leu Leu Arg Lys Cys Leu Glu Glu Leu Gln Lys 
    130                 135                 140                 


Arg Phe Ile Leu Asn Leu Pro Thr Phe Ser Val Arg Ile Ile Asp Lys 
145                 150                 155                 160 


Asn Gly Ile His Asp Leu Asp Asn Ile Ser Phe Pro Lys Gln Gly Ser 
                165                 170                 175     


<210>  5891
<211>  709
<212>  DNA
<213>  Homosapiens

<400>  5891
gagagcgccg tggaagtcgt gctgcaggcg tcgcgccaat cttcgctctg aggtgctgtc     60

tcaccgatca tgacaagatg tttaagatga gtgaaaagat attactcctg tgtgttggag    120

aggctggaga cactgtacag tttgcagaat atattcagaa aaacgtgcaa ctttataaga    180

tgcgaaatgg atatgaattg tctcccacgg cagcagctaa cttcacacgc cgaaacctgg    240

ctgactgtct tcggagtcgg accccatatc atgtgaacct cctcctggct ggctatgatg    300

agcatgaagg gccagcgctg tattacatgg actacctggc agccttggcc aaggcccctt    360

ttgcagccca cggctatggt gccttcctga ctctcagtat cctcgaccga tactacacac    420

cgactatctc acgtgagagg gcagtggaac tccttaggaa atgtctggag gagctccaga    480

aacgcttcat cctgaatctg ccaaccttca gtgttcgaat cattgacaaa aatggcatcc    540

atgacctgga taacatttcc ttccccaaac agggctccta acatcatgtc ctccctccca    600

cttgccaggg aacttttttt tgatgggctc ctttattttt ttctactctt ttcaggcgca    660

ctcttgataa atggttaatt cagaataaag gtgactatgg atataattg                709


<210>  5892
<211>  167
<212>  PRT
<213>  Homosapiens

<400>  5892

Met Phe Lys Met Ser Glu Lys Ile Leu Leu Leu Cys Val Gly Glu Ala 
1               5                   10                  15      


Gly Asp Thr Val Gln Phe Ala Glu Tyr Ile Gln Lys Asn Val Gln Leu 
            20                  25                  30          


Tyr Lys Met Arg Asn Gly Tyr Glu Leu Ser Pro Thr Ala Ala Ala Asn 
        35                  40                  45              


Phe Thr Arg Arg Asn Leu Ala Asp Cys Leu Arg Ser Arg Thr Pro Tyr 
    50                  55                  60                  


His Val Asn Leu Leu Leu Ala Gly Tyr Asp Glu His Glu Gly Pro Ala 
65                  70                  75                  80  


Leu Tyr Tyr Met Asp Tyr Leu Ala Ala Leu Ala Lys Ala Pro Phe Ala 
                85                  90                  95      


Ala His Gly Tyr Gly Ala Phe Leu Thr Leu Ser Ile Leu Asp Arg Tyr 
            100                 105                 110         


Tyr Thr Pro Thr Ile Ser Arg Glu Arg Ala Val Glu Leu Leu Arg Lys 
        115                 120                 125             


Cys Leu Glu Glu Leu Gln Lys Arg Phe Ile Leu Asn Leu Pro Thr Phe 
    130                 135                 140                 


Ser Val Arg Ile Ile Asp Lys Asn Gly Ile His Asp Leu Asp Asn Ile 
145                 150                 155                 160 


Ser Phe Pro Lys Gln Gly Ser 
                165         


<210>  5893
<211>  1146
<212>  DNA
<213>  Homosapiens

<400>  5893
ggggagattt taccgagcaa cgtagggaaa cggctgcctg gctacctacc cctttttgac     60

acccacacgt gctcggcacc ttacatacac tgcgtgattt tatcctaaag ccacttttaa    120

aatcttagtg tgtaaacaga gaaactgggc gtcacataag gcaagtgacc tgcacagcct    180

gctccggagg agacccgtac gatcccagag acaagcactg aacataaggc acccggcgcc    240

gcgcccgctt tgcaacctct cgcgacagtt gtacgtcatc cgagagcgcc gtggaagtcg    300

tgctgcaggc gtcgcgccaa tcttcgctct gaggtgctgt ctcaccggtg agacctggaa    360

gcgggcgagt ctcgtgctgt gtcggacctg cagcccctgg ccttccgcca ccatggagta    420

cctcatcggt atccaaggcc ccgactatgt tcttgtcgcc tccgaccggg tggccgccag    480

caatattgtc cagatgaagg acgatcatga caagatgttt aagatgagtg aaaagatatt    540

actcctgtgt gttggagagg ctggagacac tgtacagttt gcagaatata ttcagaaaaa    600

cgtgcaactt tataagatgc gaaatggata tgaattgtct cccacggcag cagctaactt    660

cacacgccga aacctggctg actgtcttcg gagtcggacc ccatatcatg tgaacctcct    720

cctggctggc tatgatgagc atgaagggcc agcgctgtat tacatggact acctggcagc    780

cttggccaag gccccttttg cagcccacgg ctatggtgcc ttcctgactc tcagtatcct    840

cgaccgatac tacacaccga ctatctcacg tgagagggca gtggaactcc ttaggaaatg    900

tctggaggag ctccagaaac gcttcatcct gaatctgcca accttcagtg ttcgaatcat    960

tgacaaaaat ggcatccatg acctggataa catttccttc cccaaacagg gctcctaaca   1020

tcatgtcctc cctcccactt gccagggaac ttttttttga tgggctcctt tatttttttc   1080

tactcttttc aggcgcactc ttgataaatg gttaattcag aataaaggtg actatggata   1140

taattg                                                              1146


<210>  5894
<211>  201
<212>  PRT
<213>  Homosapiens

<400>  5894

Met Glu Tyr Leu Ile Gly Ile Gln Gly Pro Asp Tyr Val Leu Val Ala 
1               5                   10                  15      


Ser Asp Arg Val Ala Ala Ser Asn Ile Val Gln Met Lys Asp Asp His 
            20                  25                  30          


Asp Lys Met Phe Lys Met Ser Glu Lys Ile Leu Leu Leu Cys Val Gly 
        35                  40                  45              


Glu Ala Gly Asp Thr Val Gln Phe Ala Glu Tyr Ile Gln Lys Asn Val 
    50                  55                  60                  


Gln Leu Tyr Lys Met Arg Asn Gly Tyr Glu Leu Ser Pro Thr Ala Ala 
65                  70                  75                  80  


Ala Asn Phe Thr Arg Arg Asn Leu Ala Asp Cys Leu Arg Ser Arg Thr 
                85                  90                  95      


Pro Tyr His Val Asn Leu Leu Leu Ala Gly Tyr Asp Glu His Glu Gly 
            100                 105                 110         


Pro Ala Leu Tyr Tyr Met Asp Tyr Leu Ala Ala Leu Ala Lys Ala Pro 
        115                 120                 125             


Phe Ala Ala His Gly Tyr Gly Ala Phe Leu Thr Leu Ser Ile Leu Asp 
    130                 135                 140                 


Arg Tyr Tyr Thr Pro Thr Ile Ser Arg Glu Arg Ala Val Glu Leu Leu 
145                 150                 155                 160 


Arg Lys Cys Leu Glu Glu Leu Gln Lys Arg Phe Ile Leu Asn Leu Pro 
                165                 170                 175     


Thr Phe Ser Val Arg Ile Ile Asp Lys Asn Gly Ile His Asp Leu Asp 
            180                 185                 190         


Asn Ile Ser Phe Pro Lys Gln Gly Ser 
        195                 200     


<210>  5895
<211>  3218
<212>  DNA
<213>  Homosapiens

<400>  5895
actttagtca agtaagcaca aaaaggaata tataattcca aattgtgata aatgctatga     60

agaaaaggaa tgtgctctga cataaagggg ggaacgaacg tgatctaggg agtcagagat    120

ctctccgaga agagatctga aataggagta agtcgagagg gggaagagaa tgctagaccg    180

agggaacagt gcgtgccaaa gccgcgtggc ggaaaggggc gtgtgggagg gtaactgcgg    240

agagggaggg tagaggacga agccggagag gcagacgaag ggcaggacgc acagagcccc    300

gcggctaccg ccttaggggt tgtcccggcg gtggggaagc cattgaggag tttaacgccg    360

gaaggtggtg actaatcaga tttcacttga aaatggcacg gtgtctgcag cgaggctaac    420

tgatgggaag ggcccagcga atgccaatag gagagagcac cggacctgga aggcctgggt    480

caacgcggcc ccgcgcgggg gcgaagcggt tccggcgcag gggcctggcg cggggctccg    540

cggaaaaccg aaccggccca cgtgggaccg gtcgctccgc cctgctgcgc agacgccgcc    600

tgactccgca gtccgggact ggggctgggc gcgctgcccg ggagccccgc acccacgcct    660

ggaccgcgga gacgcccagg ccgaggaacc cccagcccag ggactagaca ccaccagggc    720

cgggcggagc cagagccaga cgcgccggag cgggcgcctc tacgccgcta gatgttcgcc    780

atccagccag ggctagctga ggggggccaa ttcctggggg acccacctcc tggattatgt    840

cagcccgagc tccaaccaga cagcaactcc aacttcatgg caagtgccaa ggatgctaac    900

gagaattggc atgggatgcc aggcagagtg gaacctatcc tgaggaggag ctcctctgag    960

tcaccctctg acaaccaagc cttccaggcc cctggatccc ctgaggaagg ggtgcgcagc   1020

cccccagagg gggcagagat tcccggggct gagcctgaga agatgggtgg tgctggcaca   1080

gtctgctccc ctctggagga caacggctat gccagcagtt ccctgagcat tgacagccgt   1140

agcagcagtc ctgagcctgc ctgtgggacc ccgcgaggcc ctggccctcc cgatcccctt   1200

ctgccctcag tggcccaggc tgtgcagcac ttacaagtcc aggagcgcta caaagagcag   1260

gagaaggaaa agcaccacgt gcacttggtg atgtaccgtc gcctggcact gctccagtgg   1320

atccggggcc tgcagcatca gttgattgac cagcaggccc gactgcagga gagcttcgac   1380

accatcctag acaaccggaa ggagcttatt cgctgtctcc agcagagggc agcaccatcc   1440

aggccccagg accaggccta agggtgtgcc tccacaagtg tgcaagggta tatgtatata   1500

tttgcaggca tgtgtgaggc gcactagtaa gtacataatt tgctggcatg attgcaggta   1560

ggcatgagtg tgtatgtgct aacatgtagg ctggtgtgtg taggcatgtg tgaataagca   1620

tgtataaatg agcttaagtg tgctgtgtgc acatgtgtac acacagctaa tttatctgca   1680

gacctatatg tgagcatgta agagtgaaca tatgtgtgtg tgtgtagtat gtaagaatga   1740

ggaactcggt atgtgcatgt gtagacaggt acccagcagt gtgtgtatat gcgcatgagt   1800

gaggatgtat aggcagaaga tgtgtgtgtc tatgagtgag tttgagtgtg caggcttgta   1860

ttaggtgtat gtgaggaagc ccttgtgtgt gcaggggtgc acatgtttgg ccacaggcat   1920

gggaggtgta tgttaggagc atgtgtgttt gtaggcagac tcatgagcag gtgtgtgcaa   1980

atacatatcc agctgcactg tgggtgtcca cccacacctt gtgttcctca tggcctaccc   2040

cagcctttct tctccactgg gtcccactgt tccctggaga cagagggcta gcatgctgtc   2100

atttatctga aggttgtggc tgacccattc tcctgggatt tcccaggcca cctctccttt   2160

ccctttccct cacttaaccc agacttgctc agctgaggct attgtccctg atgttggctt   2220

tacttgtagg aggtttagtg gctgctctgg cctgccatgg aattttggct gcaattttgg   2280

cagtgtgtgg agaactggta tcaggaaagg gaaccaggag tagtgatgaa gatgatggtg   2340

gggatgggga cagaggacat aggggactgt ccctcttgaa ctctgccttt gggcacatgg   2400

gagatgggga caggaaagat gataacagtg gaaccctgtg aagaatagga gaatgggaat   2460

tctaaaatac cagttcccaa acaaaccatc tctccattgg aaaaggagct gttgcaaacc   2520

gtgttcattt aagcttctga tgaaaagcaa tgtatgttta taagcttgca agtaacagac   2580

aagatgttcc aaggccgatg aggaaaatat cgcttccctg tctctgcctc taccttgctg   2640

tgcctctctg gctttagcag cattggatgt tgaattggtt tggttcattt ctctgaagtc   2700

ggactgtcag gaggagccag aggttggctt tctgggatgt gaaggggaca gtgtcagcct   2760

aagcctctgg agatgcttag gatgctgaat tttaacccct tctttcactg catggccctt   2820

caaacaggga ttggcaggct ccgcgagtta cagagtgggt gagtcttgga gagaaccaac   2880

gactaaggta gcttagctct ctgctttgtt cttgggagcc aagagaatgc aagatcctgg   2940

tgggtgagca gtggtatgaa gaggggacac tggtgggtga acagtggcat ggaagtcact   3000

gatgcagcct ctggccctca gtctccctat cggcaaagtg gggggctctt cctatctcta   3060

aagagtttca tccctgacag gtggatgggt gaaagatcca gagagtgggg gtgaggggtg   3120

ggccctgaag actttttgtc tgtagctctt gcatattgag tgtataaacc cggcttctgg   3180

accaacccaa gatgaataaa ctggggcaga aaattaca                           3218


<210>  5896
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  5896

Met Phe Ala Ile Gln Pro Gly Leu Ala Glu Gly Gly Gln Phe Leu Gly 
1               5                   10                  15      


Asp Pro Pro Pro Gly Leu Cys Gln Pro Glu Leu Gln Pro Asp Ser Asn 
            20                  25                  30          


Ser Asn Phe Met Ala Ser Ala Lys Asp Ala Asn Glu Asn Trp His Gly 
        35                  40                  45              


Met Pro Gly Arg Val Glu Pro Ile Leu Arg Arg Ser Ser Ser Glu Ser 
    50                  55                  60                  


Pro Ser Asp Asn Gln Ala Phe Gln Ala Pro Gly Ser Pro Glu Glu Gly 
65                  70                  75                  80  


Val Arg Ser Pro Pro Glu Gly Ala Glu Ile Pro Gly Ala Glu Pro Glu 
                85                  90                  95      


Lys Met Gly Gly Ala Gly Thr Val Cys Ser Pro Leu Glu Asp Asn Gly 
            100                 105                 110         


Tyr Ala Ser Ser Ser Leu Ser Ile Asp Ser Arg Ser Ser Ser Pro Glu 
        115                 120                 125             


Pro Ala Cys Gly Thr Pro Arg Gly Pro Gly Pro Pro Asp Pro Leu Leu 
    130                 135                 140                 


Pro Ser Val Ala Gln Ala Val Gln His Leu Gln Val Gln Glu Arg Tyr 
145                 150                 155                 160 


Lys Glu Gln Glu Lys Glu Lys His His Val His Leu Val Met Tyr Arg 
                165                 170                 175     


Arg Leu Ala Leu Leu Gln Trp Ile Arg Gly Leu Gln His Gln Leu Ile 
            180                 185                 190         


Asp Gln Gln Ala Arg Leu Gln Glu Ser Phe Asp Thr Ile Leu Asp Asn 
        195                 200                 205             


Arg Lys Glu Leu Ile Arg Cys Leu Gln Gln Arg Ala Ala Pro Ser Arg 
    210                 215                 220                 


Pro Gln Asp Gln Ala 
225                 


<210>  5897
<211>  3393
<212>  DNA
<213>  Homosapiens

<400>  5897
actttagtca agtaagcaca aaaaggaata tataattcca aattgtgata aatgctatga     60

agaaaaggaa tgtgctctga cataaagggg ggaacgaacg tgatctaggg agtcagagat    120

ctctccgaga agagatctga aataggagta agtcgagagg gggaagagaa tgctagaccg    180

agggaacagt gcgtgccaaa gccgcgtggc ggaaaggggc gtgtgggagg gtaactgcgg    240

agagggaggg tagaggacga agccggagag gcagacgaag ggcaggacgc acagagcccc    300

gcggctaccg ccttaggggt tgtcccggcg gtggggaagc cattgaggag tttaacgccg    360

gaaggtggtg actaatcaga tttcacttga aaatggcacg gtgtctgcag cgaggctaac    420

tgatgggaag ggcccagcga atgccaatag gagagagcac cggacctgga aggcctgggt    480

caacgcggcc ccgcgcgggg gcgaagcggt tccggcgcag gggcctggcg cggggctccg    540

cggaaaaccg aaccggccca cgtgggaccg gtcgctccgc cctgctgcgc agacgccgcc    600

tgactccgca gtccgggact ggggctgggc gcgctgcccg ggagccccgc acccacgcct    660

ggaccgcgga gacgcccagg ccgaggaacc cccagcccag ggactagaca ccaccagggc    720

cgggcggagc cagagccaga cgcgccggag cgggcgcctc tacgccggtt ggatagcagt    780

tggatctggg ctgaagacag atctgagagt caccagcata tgatggtctt tgaagctaca    840

gcagagaatg aggtcctctg gagagaaatg cacaaaatca gaagacagcc tggctctgag    900

gacggaggaa aaaccctttg caggagactg agaatgaaca ggctagatgt tcgccatcca    960

gccagggcta gctgaggggg gccaattcct gggggaccca cctcctggat tatgtcagcc   1020

cgagctccaa ccagacagca actccaactt catggcaagt gccaaggatg ctaacgagaa   1080

ttggcatggg atgccaggca gagtggaacc tatcctgagg aggagctcct ctgagtcacc   1140

ctctgacaac caagccttcc aggcccctgg atcccctgag gaaggggtgc gcagcccccc   1200

agagggggca gagattcccg gggctgagcc tgagaagatg ggtggtgctg gcacagtctg   1260

ctcccctctg gaggacaacg gctatgccag cagttccctg agcattgaca gccgtagcag   1320

cagtcctgag cctgcctgtg ggaccccgcg aggccctggc cctcccgatc cccttctgcc   1380

ctcagtggcc caggctgtgc agcacttaca agtccaggag cgctacaaag agcaggagaa   1440

ggaaaagcac cacgtgcact tggtgatgta ccgtcgcctg gcactgctcc agtggatccg   1500

gggcctgcag catcagttga ttgaccagca ggcccgactg caggagagct tcgacaccat   1560

cctagacaac cggaaggagc ttattcgctg tctccagcag agggcagcac catccaggcc   1620

ccaggaccag gcctaagggt gtgcctccac aagtgtgcaa gggtatatgt atatatttgc   1680

aggcatgtgt gaggcgcact agtaagtaca taatttgctg gcatgattgc aggtaggcat   1740

gagtgtgtat gtgctaacat gtaggctggt gtgtgtaggc atgtgtgaat aagcatgtat   1800

aaatgagctt aagtgtgctg tgtgcacatg tgtacacaca gctaatttat ctgcagacct   1860

atatgtgagc atgtaagagt gaacatatgt gtgtgtgtgt agtatgtaag aatgaggaac   1920

tcggtatgtg catgtgtaga caggtaccca gcagtgtgtg tatatgcgca tgagtgagga   1980

tgtataggca gaagatgtgt gtgtctatga gtgagtttga gtgtgcaggc ttgtattagg   2040

tgtatgtgag gaagcccttg tgtgtgcagg ggtgcacatg tttggccaca ggcatgggag   2100

gtgtatgtta ggagcatgtg tgtttgtagg cagactcatg agcaggtgtg tgcaaataca   2160

tatccagctg cactgtgggt gtccacccac accttgtgtt cctcatggcc taccccagcc   2220

tttcttctcc actgggtccc actgttccct ggagacagag ggctagcatg ctgtcattta   2280

tctgaaggtt gtggctgacc cattctcctg ggatttccca ggccacctct cctttccctt   2340

tccctcactt aacccagact tgctcagctg aggctattgt ccctgatgtt ggctttactt   2400

gtaggaggtt tagtggctgc tctggcctgc catggaattt tggctgcaat tttggcagtg   2460

tgtggagaac tggtatcagg aaagggaacc aggagtagtg atgaagatga tggtggggat   2520

ggggacagag gacatagggg actgtccctc ttgaactctg cctttgggca catgggagat   2580

ggggacagga aagatgataa cagtggaacc ctgtgaagaa taggagaatg ggaattctaa   2640

aataccagtt cccaaacaaa ccatctctcc attggaaaag gagctgttgc aaaccgtgtt   2700

catttaagct tctgatgaaa agcaatgtat gtttataagc ttgcaagtaa cagacaagat   2760

gttccaaggc cgatgaggaa aatatcgctt ccctgtctct gcctctacct tgctgtgcct   2820

ctctggcttt agcagcattg gatgttgaat tggtttggtt catttctctg aagtcggact   2880

gtcaggagga gccagaggtt ggctttctgg gatgtgaagg ggacagtgtc agcctaagcc   2940

tctggagatg cttaggatgc tgaattttaa ccccttcttt cactgcatgg cccttcaaac   3000

agggattggc aggctccgcg agttacagag tgggtgagtc ttggagagaa ccaacgacta   3060

aggtagctta gctctctgct ttgttcttgg gagccaagag aatgcaagat cctggtgggt   3120

gagcagtggt atgaagaggg gacactggtg ggtgaacagt ggcatggaag tcactgatgc   3180

agcctctggc cctcagtctc cctatcggca aagtgggggg ctcttcctat ctctaaagag   3240

tttcatccct gacaggtgga tgggtgaaag atccagagag tgggggtgag gggtgggccc   3300

tgaagacttt ttgtctgtag ctcttgcata ttgagtgtat aaacccggct tctggaccaa   3360

cccaagatga ataaactggg gcagaaaatt aca                                3393


<210>  5898
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  5898

Met Met Val Phe Glu Ala Thr Ala Glu Asn Glu Val Leu Trp Arg Glu 
1               5                   10                  15      


Met His Lys Ile Arg Arg Gln Pro Gly Ser Glu Asp Gly Gly Lys Thr 
            20                  25                  30          


Leu Cys Arg Arg Leu Arg Met Asn Arg Leu Asp Val Arg His Pro Ala 
        35                  40                  45              


Arg Ala Ser 
    50      


<210>  5899
<211>  3051
<212>  DNA
<213>  Homosapiens

<400>  5899
actttagtca agtaagcaca aaaaggaata tataattcca aattgtgata aatgctatga     60

agaaaaggaa tgtgctctga cataaagggg ggaacgaacg tgatctaggg agtcagagat    120

ctctccgaga agagatctga aataggagta agtcgagagg gggaagagaa tgctagaccg    180

agggaacagt gcgtgccaaa gccgcgtggc ggaaaggggc gtgtgggagg gtaactgcgg    240

agagggaggg tagaggacga agccggagag gcagacgaag ggcaggacgc acagagcccc    300

gcggctaccg ccttaggggt tgtcccggcg gtggggaagc cattgaggag tttaacgccg    360

gaaggtggtg actaatcaga tttcacttga aaatggcacg gtgtctgcag cgaggctaac    420

tgatgggaag ggcccagcga atgccaatag gagagagcac cggacctgga aggcctgggt    480

caacgcggcc ccgcgcgggg gcgaagcggt tccggcgcag gggcctggcg cggggctccg    540

cggaaaaccg aaccggccca cgtgggaccg gtcgctccgc cctgctgcgc agacgccgcc    600

tgactccgca gtccgggact ggggctgggc gcgctgcccg ggagccccgc acccacgcct    660

ggaccgcgga gacgcccagg ccgaggaacc cccagcccag ggactagaca ccaccagggc    720

cgggcggagc cagagccaga cgcgccggag cgggcgcctc tacgccgcta gatgttcgcc    780

atccagccag ggctagctga ggggggccaa ttcctggggg acccacctcc tggattatgt    840

cagcccgagc tccaaccaga cagcaactcc aacttcatgg caagtgccaa ggatgctaac    900

gagaattggc atgggatgcc aggcagagtg gaacaacggc tatgccagca gttccctgag    960

cattgacagc cgtagcagca gtcctgagcc tgcctgtggg accccgcgag gccctggccc   1020

tcccgatccc cttctgccct cagtggccca ggctgtgcag cacttacaag tccaggagcg   1080

ctacaaagag caggagaagg aaaagcacca cgtgcacttg gtgatgtacc gtcgcctggc   1140

actgctccag tggatccggg gcctgcagca tcagttgatt gaccagcagg cccgactgca   1200

ggagagcttc gacaccatcc tagacaaccg gaaggagctt attcgctgtc tccagcagag   1260

ggcagcacca tccaggcccc aggaccaggc ctaagggtgt gcctccacaa gtgtgcaagg   1320

gtatatgtat atatttgcag gcatgtgtga ggcgcactag taagtacata atttgctggc   1380

atgattgcag gtaggcatga gtgtgtatgt gctaacatgt aggctggtgt gtgtaggcat   1440

gtgtgaataa gcatgtataa atgagcttaa gtgtgctgtg tgcacatgtg tacacacagc   1500

taatttatct gcagacctat atgtgagcat gtaagagtga acatatgtgt gtgtgtgtag   1560

tatgtaagaa tgaggaactc ggtatgtgca tgtgtagaca ggtacccagc agtgtgtgta   1620

tatgcgcatg agtgaggatg tataggcaga agatgtgtgt gtctatgagt gagtttgagt   1680

gtgcaggctt gtattaggtg tatgtgagga agcccttgtg tgtgcagggg tgcacatgtt   1740

tggccacagg catgggaggt gtatgttagg agcatgtgtg tttgtaggca gactcatgag   1800

caggtgtgtg caaatacata tccagctgca ctgtgggtgt ccacccacac cttgtgttcc   1860

tcatggccta ccccagcctt tcttctccac tgggtcccac tgttccctgg agacagaggg   1920

ctagcatgct gtcatttatc tgaaggttgt ggctgaccca ttctcctggg atttcccagg   1980

ccacctctcc tttccctttc cctcacttaa cccagacttg ctcagctgag gctattgtcc   2040

ctgatgttgg ctttacttgt aggaggttta gtggctgctc tggcctgcca tggaattttg   2100

gctgcaattt tggcagtgtg tggagaactg gtatcaggaa agggaaccag gagtagtgat   2160

gaagatgatg gtggggatgg ggacagagga cataggggac tgtccctctt gaactctgcc   2220

tttgggcaca tgggagatgg ggacaggaaa gatgataaca gtggaaccct gtgaagaata   2280

ggagaatggg aattctaaaa taccagttcc caaacaaacc atctctccat tggaaaagga   2340

gctgttgcaa accgtgttca tttaagcttc tgatgaaaag caatgtatgt ttataagctt   2400

gcaagtaaca gacaagatgt tccaaggccg atgaggaaaa tatcgcttcc ctgtctctgc   2460

ctctaccttg ctgtgcctct ctggctttag cagcattgga tgttgaattg gtttggttca   2520

tttctctgaa gtcggactgt caggaggagc cagaggttgg ctttctggga tgtgaagggg   2580

acagtgtcag cctaagcctc tggagatgct taggatgctg aattttaacc ccttctttca   2640

ctgcatggcc cttcaaacag ggattggcag gctccgcgag ttacagagtg ggtgagtctt   2700

ggagagaacc aacgactaag gtagcttagc tctctgcttt gttcttggga gccaagagaa   2760

tgcaagatcc tggtgggtga gcagtggtat gaagagggga cactggtggg tgaacagtgg   2820

catggaagtc actgatgcag cctctggccc tcagtctccc tatcggcaaa gtggggggct   2880

cttcctatct ctaaagagtt tcatccctga caggtggatg ggtgaaagat ccagagagtg   2940

ggggtgaggg gtgggccctg aagacttttt gtctgtagct cttgcatatt gagtgtataa   3000

acccggcttc tggaccaacc caagatgaat aaactggggc agaaaattac a            3051


<210>  5900
<211>  133
<212>  PRT
<213>  Homosapiens

<400>  5900

Met Leu Thr Arg Ile Gly Met Gly Cys Gln Ala Glu Trp Asn Asn Gly 
1               5                   10                  15      


Tyr Ala Ser Ser Ser Leu Ser Ile Asp Ser Arg Ser Ser Ser Pro Glu 
            20                  25                  30          


Pro Ala Cys Gly Thr Pro Arg Gly Pro Gly Pro Pro Asp Pro Leu Leu 
        35                  40                  45              


Pro Ser Val Ala Gln Ala Val Gln His Leu Gln Val Gln Glu Arg Tyr 
    50                  55                  60                  


Lys Glu Gln Glu Lys Glu Lys His His Val His Leu Val Met Tyr Arg 
65                  70                  75                  80  


Arg Leu Ala Leu Leu Gln Trp Ile Arg Gly Leu Gln His Gln Leu Ile 
                85                  90                  95      


Asp Gln Gln Ala Arg Leu Gln Glu Ser Phe Asp Thr Ile Leu Asp Asn 
            100                 105                 110         


Arg Lys Glu Leu Ile Arg Cys Leu Gln Gln Arg Ala Ala Pro Ser Arg 
        115                 120                 125             


Pro Gln Asp Gln Ala 
    130             


<210>  5901
<211>  4780
<212>  DNA
<213>  Homosapiens

<400>  5901
gaaagcaaga acagcactgc tgggctggag acggcgggag ccgctgctct ccggctgagg     60

gaatcagaga cagctccgtc cctagtggag cgcaggggag gcagaagtca tgacaggcga    120

ggtgggttct gaggttcacc tagaaatcaa tgacccaaac gtcatttcac aagaggaagc    180

agatagtcct tcagatagtg gacagggcag ctatgaaaca attggaccct tgagtgaagg    240

agattcagat gaagagatat ttgtaagtaa gaagttgaaa aacaggaagg ttctacaaga    300

cagtgattcc gaaacagagg acacaaatgc ctctccagag aaaactacct atgacagtgc    360

cgaggaggaa aataaagaga atttatatgc tgggaaaaat acaaaaatca aaaggattta    420

caaaactgtg gcagacagtg atgaaagtta catggaaaag tctttgtatc aggaaaatct    480

tgaagcgcaa gtgaaacctt gcttagagct gagtcttcag tctggaaact ctacagactt    540

taccactgac agaaagagtt ccaaaaagca catacatgat aaagaaggaa ctgcaggaaa    600

agcaaaagta aaatcaaaaa gaagacttga gaaagaggag agaaaaatgg aaaaaattag    660

acagctaaaa aagaaggaaa caaaaaacca ggaagatgat gtagaacagc catttaatga    720

cagtggctgt cttcttgtgg ataaagacct ttttgaaact gggttggagg atgaaaataa    780

ctctccattg gaagatgaag agtcattaga atcaataaga gcagctgtaa aaaacaaagt    840

aaaaaagcac aagaaaaaag aaccatcttt ggagagtggg gtccattcat ttgaggaagg    900

aagtgagtta tcaaaaggaa ccacgaggaa ggaaagaaag gcagccagat taagtaaaga    960

agcattaaaa caactgcata gtgagactca gcgccttatt cgagagtctg cactgaacct   1020

tccatatcat atgcctgaga ataaaaccat tcatgatttc ttcaaacgta aaccccggcc   1080

cacttgccac ggaaatgcca tggcactatt gaagtcatct aaatatcagt caagccatca   1140

caaagaaatc atagacactg caaatactac tgaaatgaac agtgatcacc atagtaaagg   1200

ttctgagcag acaacaggtg cagaaaatga agtggaaact aatgcactcc ctgtagtttc   1260

aaaggaaacc cagatcatta ctggatcaga tgagtcttgc aggaaggatt tggtaaaaaa   1320

tgaagagcta gaaattcagg agaaacagaa gcagagtgac attagacctt cacctgggga   1380

cagctcagtg ttgcaacagg aatccaactt cctcgggaac aatcacagtg aggaatgtca   1440

ggttggaggg cttgtagcat ttgaacctca tgccctggag ggtgaaggcc cccaaaatcc   1500

agaagaaaca gatgagaaag tggaagagcc tgagcagcaa aataaatcat cagcagttgg   1560

gccacctgaa aaagtgagac ggtttactct ggatagactt aagcaactgg gagtagatgt   1620

ttccattaaa ccacggctag gtgctgatga agattccttt gtgatacttg aacctgaaac   1680

caacagagaa ctggaagcct tgaagcagcg tttctggaag catgctaatc cagcagccaa   1740

acccagggct ggtcagacag tgaatgtgaa cgtcatagtg aaagacatgg gcactgatgg   1800

aaaggaagag ctaaaagcag atgtggtacc tgtgacttta gcacctaaga agttggatgg   1860

agcaagccac acaaaaccag gtgaaaagct tcaggtgtta aaagctaaac tgcaagaagc   1920

aatgaaactc cgaaggtttg aggagcgcca gaagcgccaa gcactgttta aattagataa   1980

tgaagatggg tttgaggaag aggaggagga agaggaagaa atgacagatg agtctgagga   2040

agatggagaa gagaaggtag agaaagaaga gaaagaggaa gaactagagg aagaggagga   2100

gaaagaagag gaggaggaag aagaaggaaa tcaggagact gcagaattcc ttcttagtag   2160

tgaagaaata gaaacaaaag atgaaaaaga aatggataaa gaaaataatg atggcagtag   2220

tgaaattggc aaggcagttg gcttcctctc tgttcccaag tctctctcat cagattctac   2280

tttacttctg tttaaggaca gctcttccaa gatgggttac tttcctactg aagaaaaatc   2340

agaaacagat gaaaactcag gcaagcagcc tagcaaactg gatgaggatg attcatgttc   2400

attgctaaca aaggagagca gccacaatag cagctttgag ctgattggct ccacgattcc   2460

atcctatcag ccttgcaaca gacaaacagg ccgtgggacc agttttttcc ctacagcagg   2520

aggattcaga tctccttccc ctgggctatt tcgagccagt ttggtcagct cagcttctaa   2580

gagttcaggg aaactgtctg agccttcact tcccatagag gattcccagg atctgtataa   2640

cgcctcccca gagcctaaga cacttttcct aggagcagga gacttccagt tctgtttaga   2700

agatgacact cagagccaac tgttggatgc agatgggttc ttaaatgtta gaaaccacag   2760

gaatcagtac caagctttga agcctcgatt gccattggcc agtatggatg agaatgccat   2820

ggatgccaac atggatgagc tgttggattt gtgtactgga aagttcacat ctcaggctga   2880

aaaacatcta cccaggaaga gtgacaagaa agagaacatg gaggaacttc tgaacctttg   2940

ttcaggaaaa ttcacttctc aggatgcctc cactccagcc tcatcagagt taaataaaca   3000

ggagaaggag agcagcatgg gtgatccaat ggaagaagca cttgctcttt gctcaggctc   3060

ttttcccaca gacaaggaag aggaagacga ggaggaggaa tttggagact ttcggcttgt   3120

ttcaaatgat aatgagtttg atagtgatga ggatgaacac agtgactctg gtaatgatct   3180

ggcactggaa gaccatgaag atgatgatga agaagaactc ctgaagcgat ctgagaagtt   3240

gaaaaggcaa atgaggttga ggaaatacct ggaggatgag gcagaggtgt caggaagtga   3300

tgtgggaagc gaagatgagt atgatgggga agaaattgat gaatatgaag aggacgtaat   3360

tgatgaagta cttccttctg atgaggaact gcagagtcaa atcaagaaaa tacacatgaa   3420

aactatgttg gatgatgata agcgacagct acgtttatac caagagaggt accttgctga   3480

tggggatctg cacagcgatg gtcctgggcg aatgaggaag tttcgatgga aaaacataga   3540

tgatgcttcc cagatggact tgttccacag agactctgat gatgatcaga ctgaagaaca   3600

gcttgatgag tcagaagcca ggtggaggaa ggagcgaatt gaacgagagc agtggcttcg   3660

ggacatggca cagcagggga aaattacagc tgaagaagaa gaagaaattg gggaggacag   3720

tcagtttatg atactggcca agaaagttac agccaaagca ctgcagaaga atgccagtcg   3780

ccctatggtt attcaggaat caaagtcttt gctcagaaat ccttttgaag ccatcagacc   3840

aggaagtgct caacaggtga agacaggctc actgctaaac cagcccaaag ctgtgcttca   3900

gaaactggct gctctctctg accataaccc cagtgctcct cgaaattcaa gaaactttgt   3960

ctttcataca ctttctcctg tcaaggctga ggcggcaaag gaatcgtcta agtctcagaa   4020

gatcccagag aaggactctg actggctcac ctggagtgga gctcctatcc ctggattctt   4080

caggctttca tttgacccac atggttaagc tgggagagac agagtccaaa gagaggcgga   4140

gaagggctat tctgggcaga acaaacaatt gatgacttta tggctctgtg gtctgggcag   4200

aactgcataa ccctagatca ccaaagctga gagcctttag gagtgaggat ttgggccagg   4260

catggtggct cacgcctgta atcccagcac tttgggaggc cgaggtgggt ggatcacaag   4320

gtcaggagat caagaccaac ctgaccaaca tggtgaaacc ccatctctac taaaaataca   4380

aaaattagct gacgtgatgc atgcacctgt aatcccagct actcaggagg ctgaggcagg   4440

agaatcgctt gaacccggga ggtggaggtt gcggtgagcc gagattgcgc cactgcactc   4500

cagcctaggc gacagagcga gactccatct caaaaaaaaa aaaaaaaaaa aaaaaagtga   4560

ggatttgggt caccccaggc tgaaggccag gggaacctga agtggataag ggaagggaga   4620

agacttaggc cacaggatct gatgtagaaa tggggctgac gtctccacct gtattttctt   4680

agctggagga gtgtgcaaag tttgaattac ttctgccttc tccttcttat ttccttttcc   4740

cttttaaaat agtcatcata atcataaaaa tttcttttcc                         4780


<210>  5902
<211>  1332
<212>  PRT
<213>  Homosapiens

<400>  5902

Met Thr Gly Glu Val Gly Ser Glu Val His Leu Glu Ile Asn Asp Pro 
1               5                   10                  15      


Asn Val Ile Ser Gln Glu Glu Ala Asp Ser Pro Ser Asp Ser Gly Gln 
            20                  25                  30          


Gly Ser Tyr Glu Thr Ile Gly Pro Leu Ser Glu Gly Asp Ser Asp Glu 
        35                  40                  45              


Glu Ile Phe Val Ser Lys Lys Leu Lys Asn Arg Lys Val Leu Gln Asp 
    50                  55                  60                  


Ser Asp Ser Glu Thr Glu Asp Thr Asn Ala Ser Pro Glu Lys Thr Thr 
65                  70                  75                  80  


Tyr Asp Ser Ala Glu Glu Glu Asn Lys Glu Asn Leu Tyr Ala Gly Lys 
                85                  90                  95      


Asn Thr Lys Ile Lys Arg Ile Tyr Lys Thr Val Ala Asp Ser Asp Glu 
            100                 105                 110         


Ser Tyr Met Glu Lys Ser Leu Tyr Gln Glu Asn Leu Glu Ala Gln Val 
        115                 120                 125             


Lys Pro Cys Leu Glu Leu Ser Leu Gln Ser Gly Asn Ser Thr Asp Phe 
    130                 135                 140                 


Thr Thr Asp Arg Lys Ser Ser Lys Lys His Ile His Asp Lys Glu Gly 
145                 150                 155                 160 


Thr Ala Gly Lys Ala Lys Val Lys Ser Lys Arg Arg Leu Glu Lys Glu 
                165                 170                 175     


Glu Arg Lys Met Glu Lys Ile Arg Gln Leu Lys Lys Lys Glu Thr Lys 
            180                 185                 190         


Asn Gln Glu Asp Asp Val Glu Gln Pro Phe Asn Asp Ser Gly Cys Leu 
        195                 200                 205             


Leu Val Asp Lys Asp Leu Phe Glu Thr Gly Leu Glu Asp Glu Asn Asn 
    210                 215                 220                 


Ser Pro Leu Glu Asp Glu Glu Ser Leu Glu Ser Ile Arg Ala Ala Val 
225                 230                 235                 240 


Lys Asn Lys Val Lys Lys His Lys Lys Lys Glu Pro Ser Leu Glu Ser 
                245                 250                 255     


Gly Val His Ser Phe Glu Glu Gly Ser Glu Leu Ser Lys Gly Thr Thr 
            260                 265                 270         


Arg Lys Glu Arg Lys Ala Ala Arg Leu Ser Lys Glu Ala Leu Lys Gln 
        275                 280                 285             


Leu His Ser Glu Thr Gln Arg Leu Ile Arg Glu Ser Ala Leu Asn Leu 
    290                 295                 300                 


Pro Tyr His Met Pro Glu Asn Lys Thr Ile His Asp Phe Phe Lys Arg 
305                 310                 315                 320 


Lys Pro Arg Pro Thr Cys His Gly Asn Ala Met Ala Leu Leu Lys Ser 
                325                 330                 335     


Ser Lys Tyr Gln Ser Ser His His Lys Glu Ile Ile Asp Thr Ala Asn 
            340                 345                 350         


Thr Thr Glu Met Asn Ser Asp His His Ser Lys Gly Ser Glu Gln Thr 
        355                 360                 365             


Thr Gly Ala Glu Asn Glu Val Glu Thr Asn Ala Leu Pro Val Val Ser 
    370                 375                 380                 


Lys Glu Thr Gln Ile Ile Thr Gly Ser Asp Glu Ser Cys Arg Lys Asp 
385                 390                 395                 400 


Leu Val Lys Asn Glu Glu Leu Glu Ile Gln Glu Lys Gln Lys Gln Ser 
                405                 410                 415     


Asp Ile Arg Pro Ser Pro Gly Asp Ser Ser Val Leu Gln Gln Glu Ser 
            420                 425                 430         


Asn Phe Leu Gly Asn Asn His Ser Glu Glu Cys Gln Val Gly Gly Leu 
        435                 440                 445             


Val Ala Phe Glu Pro His Ala Leu Glu Gly Glu Gly Pro Gln Asn Pro 
    450                 455                 460                 


Glu Glu Thr Asp Glu Lys Val Glu Glu Pro Glu Gln Gln Asn Lys Ser 
465                 470                 475                 480 


Ser Ala Val Gly Pro Pro Glu Lys Val Arg Arg Phe Thr Leu Asp Arg 
                485                 490                 495     


Leu Lys Gln Leu Gly Val Asp Val Ser Ile Lys Pro Arg Leu Gly Ala 
            500                 505                 510         


Asp Glu Asp Ser Phe Val Ile Leu Glu Pro Glu Thr Asn Arg Glu Leu 
        515                 520                 525             


Glu Ala Leu Lys Gln Arg Phe Trp Lys His Ala Asn Pro Ala Ala Lys 
    530                 535                 540                 


Pro Arg Ala Gly Gln Thr Val Asn Val Asn Val Ile Val Lys Asp Met 
545                 550                 555                 560 


Gly Thr Asp Gly Lys Glu Glu Leu Lys Ala Asp Val Val Pro Val Thr 
                565                 570                 575     


Leu Ala Pro Lys Lys Leu Asp Gly Ala Ser His Thr Lys Pro Gly Glu 
            580                 585                 590         


Lys Leu Gln Val Leu Lys Ala Lys Leu Gln Glu Ala Met Lys Leu Arg 
        595                 600                 605             


Arg Phe Glu Glu Arg Gln Lys Arg Gln Ala Leu Phe Lys Leu Asp Asn 
    610                 615                 620                 


Glu Asp Gly Phe Glu Glu Glu Glu Glu Glu Glu Glu Glu Met Thr Asp 
625                 630                 635                 640 


Glu Ser Glu Glu Asp Gly Glu Glu Lys Val Glu Lys Glu Glu Lys Glu 
                645                 650                 655     


Glu Glu Leu Glu Glu Glu Glu Glu Lys Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gly Asn Gln Glu Thr Ala Glu Phe Leu Leu Ser Ser Glu Glu Ile Glu 
        675                 680                 685             


Thr Lys Asp Glu Lys Glu Met Asp Lys Glu Asn Asn Asp Gly Ser Ser 
    690                 695                 700                 


Glu Ile Gly Lys Ala Val Gly Phe Leu Ser Val Pro Lys Ser Leu Ser 
705                 710                 715                 720 


Ser Asp Ser Thr Leu Leu Leu Phe Lys Asp Ser Ser Ser Lys Met Gly 
                725                 730                 735     


Tyr Phe Pro Thr Glu Glu Lys Ser Glu Thr Asp Glu Asn Ser Gly Lys 
            740                 745                 750         


Gln Pro Ser Lys Leu Asp Glu Asp Asp Ser Cys Ser Leu Leu Thr Lys 
        755                 760                 765             


Glu Ser Ser His Asn Ser Ser Phe Glu Leu Ile Gly Ser Thr Ile Pro 
    770                 775                 780                 


Ser Tyr Gln Pro Cys Asn Arg Gln Thr Gly Arg Gly Thr Ser Phe Phe 
785                 790                 795                 800 


Pro Thr Ala Gly Gly Phe Arg Ser Pro Ser Pro Gly Leu Phe Arg Ala 
                805                 810                 815     


Ser Leu Val Ser Ser Ala Ser Lys Ser Ser Gly Lys Leu Ser Glu Pro 
            820                 825                 830         


Ser Leu Pro Ile Glu Asp Ser Gln Asp Leu Tyr Asn Ala Ser Pro Glu 
        835                 840                 845             


Pro Lys Thr Leu Phe Leu Gly Ala Gly Asp Phe Gln Phe Cys Leu Glu 
    850                 855                 860                 


Asp Asp Thr Gln Ser Gln Leu Leu Asp Ala Asp Gly Phe Leu Asn Val 
865                 870                 875                 880 


Arg Asn His Arg Asn Gln Tyr Gln Ala Leu Lys Pro Arg Leu Pro Leu 
                885                 890                 895     


Ala Ser Met Asp Glu Asn Ala Met Asp Ala Asn Met Asp Glu Leu Leu 
            900                 905                 910         


Asp Leu Cys Thr Gly Lys Phe Thr Ser Gln Ala Glu Lys His Leu Pro 
        915                 920                 925             


Arg Lys Ser Asp Lys Lys Glu Asn Met Glu Glu Leu Leu Asn Leu Cys 
    930                 935                 940                 


Ser Gly Lys Phe Thr Ser Gln Asp Ala Ser Thr Pro Ala Ser Ser Glu 
945                 950                 955                 960 


Leu Asn Lys Gln Glu Lys Glu Ser Ser Met Gly Asp Pro Met Glu Glu 
                965                 970                 975     


Ala Leu Ala Leu Cys Ser Gly Ser Phe Pro Thr Asp Lys Glu Glu Glu 
            980                 985                 990         


Asp Glu Glu Glu Glu Phe Gly Asp  Phe Arg Leu Val Ser  Asn Asp Asn 
        995                 1000                 1005             


Glu Phe  Asp Ser Asp Glu Asp  Glu His Ser Asp Ser  Gly Asn Asp 
    1010                 1015                 1020             


Leu Ala  Leu Glu Asp His Glu  Asp Asp Asp Glu Glu  Glu Leu Leu 
    1025                 1030                 1035             


Lys Arg  Ser Glu Lys Leu Lys  Arg Gln Met Arg Leu  Arg Lys Tyr 
    1040                 1045                 1050             


Leu Glu  Asp Glu Ala Glu Val  Ser Gly Ser Asp Val  Gly Ser Glu 
    1055                 1060                 1065             


Asp Glu  Tyr Asp Gly Glu Glu  Ile Asp Glu Tyr Glu  Glu Asp Val 
    1070                 1075                 1080             


Ile Asp  Glu Val Leu Pro Ser  Asp Glu Glu Leu Gln  Ser Gln Ile 
    1085                 1090                 1095             


Lys Lys  Ile His Met Lys Thr  Met Leu Asp Asp Asp  Lys Arg Gln 
    1100                 1105                 1110             


Leu Arg  Leu Tyr Gln Glu Arg  Tyr Leu Ala Asp Gly  Asp Leu His 
    1115                 1120                 1125             


Ser Asp  Gly Pro Gly Arg Met  Arg Lys Phe Arg Trp  Lys Asn Ile 
    1130                 1135                 1140             


Asp Asp  Ala Ser Gln Met Asp  Leu Phe His Arg Asp  Ser Asp Asp 
    1145                 1150                 1155             


Asp Gln  Thr Glu Glu Gln Leu  Asp Glu Ser Glu Ala  Arg Trp Arg 
    1160                 1165                 1170             


Lys Glu  Arg Ile Glu Arg Glu  Gln Trp Leu Arg Asp  Met Ala Gln 
    1175                 1180                 1185             


Gln Gly  Lys Ile Thr Ala Glu  Glu Glu Glu Glu Ile  Gly Glu Asp 
    1190                 1195                 1200             


Ser Gln  Phe Met Ile Leu Ala  Lys Lys Val Thr Ala  Lys Ala Leu 
    1205                 1210                 1215             


Gln Lys  Asn Ala Ser Arg Pro  Met Val Ile Gln Glu  Ser Lys Ser 
    1220                 1225                 1230             


Leu Leu  Arg Asn Pro Phe Glu  Ala Ile Arg Pro Gly  Ser Ala Gln 
    1235                 1240                 1245             


Gln Val  Lys Thr Gly Ser Leu  Leu Asn Gln Pro Lys  Ala Val Leu 
    1250                 1255                 1260             


Gln Lys  Leu Ala Ala Leu Ser  Asp His Asn Pro Ser  Ala Pro Arg 
    1265                 1270                 1275             


Asn Ser  Arg Asn Phe Val Phe  His Thr Leu Ser Pro  Val Lys Ala 
    1280                 1285                 1290             


Glu Ala  Ala Lys Glu Ser Ser  Lys Ser Gln Lys Ile  Pro Glu Lys 
    1295                 1300                 1305             


Asp Ser  Asp Trp Leu Thr Trp  Ser Gly Ala Pro Ile  Pro Gly Phe 
    1310                 1315                 1320             


Phe Arg  Leu Ser Phe Asp Pro  His Gly 
    1325                 1330         


<210>  5903
<211>  2745
<212>  DNA
<213>  Homosapiens

<400>  5903
gacagtgtac ttagatctta gactattggg cagtagagac tgtattcatg agtatatgtg     60

gctggtttta ctttatgttc taaggctcag agtagttaat tctggctttc tctagttgcc    120

caggattgta tacctaagtg ttagagccag tcgccctatg gttattcagg aatcaaagtc    180

tttgctcaga aatccttttg aagccatcag accaggaagt gctcaacagg tgaagacagg    240

ctcactgcta aaccagccca aagctgtgct tcagaaactg gctgctctct ctgaccataa    300

ccccagtgct cctcgaaatt caagaaactt tgtctttcat acactttctc ctgtcaaggc    360

tgaggcggca aaggaatcgt ctaagtctca ggtaaagaaa aggggtccat ctttcatgac    420

ttctccttca cctaagcacc tcaaaacaga tgatagcact tcaggattga cgcgaagcat    480

cttcaaatat ttggagagct aacaccatca aaggtgccaa aatctacatt gagactgctt    540

tgagaagttt ctagcactga aagttggaat tgacactcca gccaatgatc cttccttctt    600

tcataatcaa tgcaataaga ttgcagacag aaattccagt gatttctact gcacagctct    660

ggacatctct tttcctagta ttattccctg aattggccac tgatttcaat tctgcagtat    720

ttacaacatc aacaactcat ggaatacttg ggtgaggttt cctttttttt ttttttttta    780

agatgggagt ctcactctgt tgcccagctt ggagtgcagt ggcgtgatct cggctcacca    840

caatctctgc ctcccaggtt caagcgattc tcctccttca gcctcccgag tagctgggat    900

tacaggcatg tgccaatacg cccagctaat ttttgtattt ttagtagaga cggggtttca    960

ccatgttggc caggctggtc ttgaactcct gacctcaaat gatccatcca cctcggcccc   1020

acaaagtgct ggtcacatgc atgagtcact gcacctggcc ttgggttagg tttcacttcc   1080

tccattagac atttgacatt ttattgtagc agctttctgg gttaatatct ctttgtgatt   1140

gatagaagtg gttggaagag gaagagtagg gaaaagtgtg acattacaga ttaaacagtg   1200

aaaatcagta ccataatgac tcctttacac ccatgagata cgtaccatga tgaccagggc   1260

tcggtgaaag aaagatttct tttttttttt ttgagatagt ctcactttgt tgcccagtct   1320

ggagtgcagt ggcgcaatct cggctcacgg caacctctgc ctcccgggtt caagtgattc   1380

tcctgtctca gcctcccaag tagctgggac tacaggtgca tgccaccaca cctggctaat   1440

ttttgtattt ttagtggaga cagggagtca ccatgttggc caggctggtc tcgatctcct   1500

gacctcaagt gatccagctg cctcagcctc ccaaagtgct gagattacag gcgtgagcca   1560

ctgtgcccag ccaaaagaac gatttcttag atggaggacc taggaaccaa cagatgggct   1620

gctgtattac tcttacccct ttcattttcc tgtatgcttc ttcccaaggc agcatcaaat   1680

tttgaattaa tttttgctgc ttaataagga cttaaactgg tacccaagtc agaaagactc   1740

tgcctctaat tttctggggc ttggggatga agataaagtg ttacacccag tgtttgtcca   1800

ccacagtctg tggggcagag agacccttcc tgggactgaa ttctcaattt gaagcactgt   1860

tgttcaaaga tctcccttct gggtctgaca agaagaaaca taacccttat ttattgcatt   1920

cttctggctt acatacattg ccctcactaa tcaatggaca tttcagcatt tcattactaa   1980

ttttgagaga aggccaccat ggaatttaat aaaaatatta ttgaagagaa ttgccatcat   2040

tctccatttt ccctgaacta ccacaagctt ctcagaattt tagacaaatg tttttcccct   2100

cagaactgag catcagtgct gctttggaaa aacattccat gtgaatactg tggtttcagt   2160

gtcaggacct gtacttgggc agttggaaga gagtgtgcca gttttttact gggagatggg   2220

aacaccaatt taattgatgc aattaggttg taggtttttt acagtttttc ttttcttttc   2280

tttttctttt tcttttcttt tcttttcttt tttttttttt gagacatagg ctggctctgt   2340

cacctaggct ggaatacaat ggcatgatct cggcttactg caacctccgc ctcctaggtt   2400

caagcaattc tgcctcggcc tcccaaatag cagggattac aggcacctgc caccactccc   2460

agctaatttt ttgtattttt attagagatg aggtttcgcc atgttggcca ggctggtctt   2520

gaactcctga cctgaggtga tccacccgtc tcggcctccc aaagtgctgg gattataggc   2580

atgagccacc gcacccggcc ggttttctac agttttctaa tactcaagat gttgactttg   2640

acaatactta tgtttgtata cttgtaatct tataatgggg aaaatgtgta taaagatgtt   2700

ttaatatgta tgtagttttt caataaatct taatgccttg aaggg                   2745


<210>  5904
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  5904

Met Val Ile Gln Glu Ser Lys Ser Leu Leu Arg Asn Pro Phe Glu Ala 
1               5                   10                  15      


Ile Arg Pro Gly Ser Ala Gln Gln Val Lys Thr Gly Ser Leu Leu Asn 
            20                  25                  30          


Gln Pro Lys Ala Val Leu Gln Lys Leu Ala Ala Leu Ser Asp His Asn 
        35                  40                  45              


Pro Ser Ala Pro Arg Asn Ser Arg Asn Phe Val Phe His Thr Leu Ser 
    50                  55                  60                  


Pro Val Lys Ala Glu Ala Ala Lys Glu Ser Ser Lys Ser Gln Val Lys 
65                  70                  75                  80  


Lys Arg Gly Pro Ser Phe Met Thr Ser Pro Ser Pro Lys His Leu Lys 
                85                  90                  95      


Thr Asp Asp Ser Thr Ser Gly Leu Thr Arg Ser Ile Phe Lys Tyr Leu 
            100                 105                 110         


Glu Ser 
        


<210>  5905
<211>  6372
<212>  DNA
<213>  Homosapiens

<400>  5905
gaaagcaaga acagcactgc tgggctggag acggcgggag ccgctgctct ccggctgagg     60

gaatcagaga cagctccgtc cctagtggag cgcaggggag gcagaagtca tgacaggcga    120

ggtgggttct gaggttcacc tagaaatcaa tgacccaaac gtcatttcac aagaggaagc    180

agatagtcct tcagatagtg gacagggcag ctatgaaaca attggaccct tgagtgaagg    240

agattcagat gaagagatat ttgtaagtaa gaagttgaaa aacaggaagg ttctacaaga    300

cagtgattcc gaaacagagg acacaaatgc ctctccagag aaaactacct atgacagtgc    360

cgaggaggaa aataaagaga atttatatgc tgggaaaaat acaaaaatca aaaggattta    420

caaaactgtg gcagacagtg atgaaagtta catggaaaag tctttgtatc aggaaaatct    480

tgaagcgcaa gtgaaacctt gcttagagct gagtcttcag tctggaaact ctacagactt    540

taccactgac agaaagagtt ccaaaaagca catacatgat aaagaaggaa ctgcaggaaa    600

agcaaaagta aaatcaaaaa gaagacttga gaaagaggag agaaaaatgg aaaaaattag    660

acagctaaaa aagaaggaaa caaaaaacca ggaagatgat gtagaacagc catttaatga    720

cagtggctgt cttcttgtgg ataaagacct ttttgaaact gggttggagg atgaaaataa    780

ctctccattg gaagatgaag agtcattaga atcaataaga gcagctgtaa aaaacaaagt    840

aaaaaagcac aagaaaaaag aaccatcttt ggagagtggg gtccattcat ttgaggaagg    900

aagtgagtta tcaaaaggaa ccacgaggaa ggaaagaaag gcagccagat taagtaaaga    960

agcattaaaa caactgcata gtgagactca gcgccttatt cgagagtctg cactgaacct   1020

tccatatcat atgcctgaga ataaaaccat tcatgatttc ttcaaacgta aaccccggcc   1080

cacttgccac ggaaatgcca tggcactatt gaagtcatct aaatatcagt caagccatca   1140

caaagaaatc atagacactg caaatactac tgaaatgaac agtgatcacc atagtaaagg   1200

ttctgagcag acaacaggtg cagaaaatga agtggaaact aatgcactcc ctgtagtttc   1260

aaaggaaacc cagatcatta ctggatcaga tgagtcttgc aggaaggatt tggtaaaaaa   1320

tgaagagcta gaaattcagg agaaacagaa gcagagtgac attagacctt cacctgggga   1380

cagctcagtg ttgcaacagg aatccaactt cctcgggaac aatcacagtg aggaatgtca   1440

ggttggaggg cttgtagcat ttgaacctca tgccctggag ggtgaaggcc cccaaaatcc   1500

agaagaaaca gatgagaaag tggaagagcc tgagcagcaa aataaatcat cagcagttgg   1560

gccacctgaa aaagtgagac ggtttactct ggatagactt aagcaactgg gagtagatgt   1620

ttccattaaa ccacggctag gtgctgatga agattccttt gtgatacttg aacctgaaac   1680

caacagagaa ctggaagcct tgaagcagcg tttctggaag catgctaatc cagcagccaa   1740

acccagggct ggtcagacag tgaatgtgaa cgtcatagtg aaagacatgg gcactgatgg   1800

aaaggaagag ctaaaagcag atgtggtacc tgtgacttta gcacctaaga agttggatgg   1860

agcaagccac acaaaaccag gtgaaaagct tcaggtgtta aaagctaaac tgcaagaagc   1920

aatgaaactc cgaaggtttg aggagcgcca gaagcgccaa gcactgttta aattagataa   1980

tgaagatggg tttgaggaag aggaggagga agaggaagaa atgacagatg agtctgagga   2040

agatggagaa gagaaggtag agaaagaaga gaaagaggaa gaactagagg aagaggagga   2100

gaaagaagag gaggaggaag aagaaggaaa tcaggagact gcagaattcc ttcttagtag   2160

tgaagaaata gaaacaaaag atgaaaaaga aatggataaa gaaaataatg atggcagtag   2220

tgaaattggc aaggcagttg gcttcctctc tgttcccaag tctctctcat cagattctac   2280

tttacttctg tttaaggaca gctcttccaa gatgggttac tttcctactg aagaaaaatc   2340

agaaacagat gaaaactcag gcaagcagcc tagcaaactg gatgaggatg attcatgttc   2400

attgctaaca aaggagagca gccacaatag cagctttgag ctgattggct ccacgattcc   2460

atcctatcag ccttgcaaca gacaaacagg ccgtgggacc agttttttcc ctacagcagg   2520

aggattcaga tctccttccc ctgggctatt tcgagccagt ttggtcagct cagcttctaa   2580

gagttcaggg aaactgtctg agccttcact tcccatagag gattcccagg atctgtataa   2640

cgcctcccca gagcctaaga cacttttcct aggagcagga gacttccagt tctgtttaga   2700

agatgacact cagagccaac tgttggatgc agatgggttc ttaaatgtta gaaaccacag   2760

gaatcagtac caagctttga agcctcgatt gccattggcc agtatggatg agaatgccat   2820

ggatgccaac atggatgagc tgttggattt gtgtactgga aagttcacat ctcaggctga   2880

aaaacatcta cccaggaaga gtgacaagaa agagaacatg gaggaacttc tgaacctttg   2940

ttcaggaaaa ttcacttctc aggatgcctc cactccagcc tcatcagagt taaataaaca   3000

ggagaaggag agcagcatgg gtgatccaat ggaagaagca cttgctcttt gctcaggctc   3060

ttttcccaca gacaaggaag aggaagacga ggaggaggaa tttggagact ttcggcttgt   3120

ttcaaatgat aatgagtttg atagtgatga ggatgaacac agtgactctg gtaatgatct   3180

ggcactggaa gaccatgaag atgatgatga agaagaactc ctgaagcgat ctgagaagtt   3240

gaaaaggcaa atgaggttga ggaaatacct ggaggatgag gcagaggtgt caggaagtga   3300

tgtgggaagc gaagatgagt atgatgggga agaaattgat gaatatgaag aggacgtaat   3360

tgatgaagta cttccttctg atgaggaact gcagagtcaa atcaagaaaa tacacatgaa   3420

aactatgttg gatgatgata agcgacagct acgtttatac caagagaggt accttgctga   3480

tggggatctg cacagcgatg gtcctgggcg aatgaggaag tttcgatgga aaaacataga   3540

tgatgcttcc cagatggact tgttccacag agactctgat gatgatcaga ctgaagaaca   3600

gcttgatgag tcagaagcca ggtggaggaa ggagcgaatt gaacgagagc agtggcttcg   3660

ggacatggca cagcagggga aaattacagc tgaagaagaa gaagaaattg gggaggacag   3720

tcagtttatg atactggcca agaaagttac agccaaagca ctgcagaaga atgccagtcg   3780

ccctatggtt attcaggaat caaagtcttt gctcagaaat ccttttgaag ccatcagacc   3840

aggaagtgct caacaggtga agacaggctc actgctaaac cagcccaaag ctgtgcttca   3900

gaaactggct gctctctctg accataaccc cagtgctcct cgaaattcaa gaaactttgt   3960

ctttcataca ctttctcctg tcaaggctga ggcggcaaag gaatcgtcta agtctcaggt   4020

aaagaaaagg ggtccatctt tcatgacttc tccttcacct aagcacctca aaacagatga   4080

tagcacttca ggattgacgc gaagcatctt caaatatttg gagagctaac accatcaaag   4140

gtgccaaaat ctacattgag actgctttga gaagtttcta gcactgaaag ttggaattga   4200

cactccagcc aatgatcctt ccttctttca taatcaatgc aataagattg cagacagaaa   4260

ttccagtgat ttctactgca cagctctgga catctctttt cctagtatta ttccctgaat   4320

tggccactga tttcaattct gcagtattta caacatcaac aactcatgga atacttgggt   4380

gaggtttcct tttttttttt ttttttaaga tgggagtctc actctgttgc ccagcttgga   4440

gtgcagtggc gtgatctcgg ctcaccacaa tctctgcctc ccaggttcaa gcgattctcc   4500

tccttcagcc tcccgagtag ctgggattac aggcatgtgc caatacgccc agctaatttt   4560

tgtattttta gtagagacgg ggtttcacca tgttggccag gctggtcttg aactcctgac   4620

ctcaaatgat ccatccacct cggccccaca aagtgctggt cacatgcatg agtcactgca   4680

cctggccttg ggttaggttt cacttcctcc attagacatt tgacatttta ttgtagcagc   4740

tttctgggtt aatatctctt tgtgattgat agaagtggtt ggaagaggaa gagtagggaa   4800

aagtgtgaca ttacagatta aacagtgaaa atcagtacca taatgactcc tttacaccca   4860

tgagatacgt accatgatga ccagggctcg gtgaaagaaa gatttctttt tttttttttg   4920

agatagtctc actttgttgc ccagtctgga gtgcagtggc gcaatctcgg ctcacggcaa   4980

cctctgcctc ccgggttcaa gtgattctcc tgtctcagcc tcccaagtag ctgggactac   5040

aggtgcatgc caccacacct ggctaatttt tgtattttta gtggagacag ggagtcacca   5100

tgttggccag gctggtctcg atctcctgac ctcaagtgat ccagctgcct cagcctccca   5160

aagtgctgag attacaggcg tgagccactg tgcccagcca aaagaacgat ttcttagatg   5220

gaggacctag gaaccaacag atgggctgct gtattactct tacccctttc attttcctgt   5280

atgcttcttc ccaaggcagc atcaaatttt gaattaattt ttgctgctta ataaggactt   5340

aaactggtac ccaagtcaga aagactctgc ctctaatttt ctggggcttg gggatgaaga   5400

taaagtgtta cacccagtgt ttgtccacca cagtctgtgg ggcagagaga cccttcctgg   5460

gactgaattc tcaatttgaa gcactgttgt tcaaagatct cccttctggg tctgacaaga   5520

agaaacataa cccttattta ttgcattctt ctggcttaca tacattgccc tcactaatca   5580

atggacattt cagcatttca ttactaattt tgagagaagg ccaccatgga atttaataaa   5640

aatattattg aagagaattg ccatcattct ccattttccc tgaactacca caagcttctc   5700

agaattttag acaaatgttt ttcccctcag aactgagcat cagtgctgct ttggaaaaac   5760

attccatgtg aatactgtgg tttcagtgtc aggacctgta cttgggcagt tggaagagag   5820

tgtgccagtt ttttactggg agatgggaac accaatttaa ttgatgcaat taggttgtag   5880

gttttttaca gtttttcttt tcttttcttt ttctttttct tttcttttct tttctttttt   5940

tttttttgag acataggctg gctctgtcac ctaggctgga atacaatggc atgatctcgg   6000

cttactgcaa cctccgcctc ctaggttcaa gcaattctgc ctcggcctcc caaatagcag   6060

ggattacagg cacctgccac cactcccagc taattttttg tatttttatt agagatgagg   6120

tttcgccatg ttggccaggc tggtcttgaa ctcctgacct gaggtgatcc acccgtctcg   6180

gcctcccaaa gtgctgggat tataggcatg agccaccgca cccggccggt tttctacagt   6240

tttctaatac tcaagatgtt gactttgaca atacttatgt ttgtatactt gtaatcttat   6300

aatggggaaa atgtgtataa agatgtttta atatgtatgt agtttttcaa taaatcttaa   6360

tgccttgaag gg                                                       6372


<210>  5906
<211>  1339
<212>  PRT
<213>  Homosapiens

<400>  5906

Met Thr Gly Glu Val Gly Ser Glu Val His Leu Glu Ile Asn Asp Pro 
1               5                   10                  15      


Asn Val Ile Ser Gln Glu Glu Ala Asp Ser Pro Ser Asp Ser Gly Gln 
            20                  25                  30          


Gly Ser Tyr Glu Thr Ile Gly Pro Leu Ser Glu Gly Asp Ser Asp Glu 
        35                  40                  45              


Glu Ile Phe Val Ser Lys Lys Leu Lys Asn Arg Lys Val Leu Gln Asp 
    50                  55                  60                  


Ser Asp Ser Glu Thr Glu Asp Thr Asn Ala Ser Pro Glu Lys Thr Thr 
65                  70                  75                  80  


Tyr Asp Ser Ala Glu Glu Glu Asn Lys Glu Asn Leu Tyr Ala Gly Lys 
                85                  90                  95      


Asn Thr Lys Ile Lys Arg Ile Tyr Lys Thr Val Ala Asp Ser Asp Glu 
            100                 105                 110         


Ser Tyr Met Glu Lys Ser Leu Tyr Gln Glu Asn Leu Glu Ala Gln Val 
        115                 120                 125             


Lys Pro Cys Leu Glu Leu Ser Leu Gln Ser Gly Asn Ser Thr Asp Phe 
    130                 135                 140                 


Thr Thr Asp Arg Lys Ser Ser Lys Lys His Ile His Asp Lys Glu Gly 
145                 150                 155                 160 


Thr Ala Gly Lys Ala Lys Val Lys Ser Lys Arg Arg Leu Glu Lys Glu 
                165                 170                 175     


Glu Arg Lys Met Glu Lys Ile Arg Gln Leu Lys Lys Lys Glu Thr Lys 
            180                 185                 190         


Asn Gln Glu Asp Asp Val Glu Gln Pro Phe Asn Asp Ser Gly Cys Leu 
        195                 200                 205             


Leu Val Asp Lys Asp Leu Phe Glu Thr Gly Leu Glu Asp Glu Asn Asn 
    210                 215                 220                 


Ser Pro Leu Glu Asp Glu Glu Ser Leu Glu Ser Ile Arg Ala Ala Val 
225                 230                 235                 240 


Lys Asn Lys Val Lys Lys His Lys Lys Lys Glu Pro Ser Leu Glu Ser 
                245                 250                 255     


Gly Val His Ser Phe Glu Glu Gly Ser Glu Leu Ser Lys Gly Thr Thr 
            260                 265                 270         


Arg Lys Glu Arg Lys Ala Ala Arg Leu Ser Lys Glu Ala Leu Lys Gln 
        275                 280                 285             


Leu His Ser Glu Thr Gln Arg Leu Ile Arg Glu Ser Ala Leu Asn Leu 
    290                 295                 300                 


Pro Tyr His Met Pro Glu Asn Lys Thr Ile His Asp Phe Phe Lys Arg 
305                 310                 315                 320 


Lys Pro Arg Pro Thr Cys His Gly Asn Ala Met Ala Leu Leu Lys Ser 
                325                 330                 335     


Ser Lys Tyr Gln Ser Ser His His Lys Glu Ile Ile Asp Thr Ala Asn 
            340                 345                 350         


Thr Thr Glu Met Asn Ser Asp His His Ser Lys Gly Ser Glu Gln Thr 
        355                 360                 365             


Thr Gly Ala Glu Asn Glu Val Glu Thr Asn Ala Leu Pro Val Val Ser 
    370                 375                 380                 


Lys Glu Thr Gln Ile Ile Thr Gly Ser Asp Glu Ser Cys Arg Lys Asp 
385                 390                 395                 400 


Leu Val Lys Asn Glu Glu Leu Glu Ile Gln Glu Lys Gln Lys Gln Ser 
                405                 410                 415     


Asp Ile Arg Pro Ser Pro Gly Asp Ser Ser Val Leu Gln Gln Glu Ser 
            420                 425                 430         


Asn Phe Leu Gly Asn Asn His Ser Glu Glu Cys Gln Val Gly Gly Leu 
        435                 440                 445             


Val Ala Phe Glu Pro His Ala Leu Glu Gly Glu Gly Pro Gln Asn Pro 
    450                 455                 460                 


Glu Glu Thr Asp Glu Lys Val Glu Glu Pro Glu Gln Gln Asn Lys Ser 
465                 470                 475                 480 


Ser Ala Val Gly Pro Pro Glu Lys Val Arg Arg Phe Thr Leu Asp Arg 
                485                 490                 495     


Leu Lys Gln Leu Gly Val Asp Val Ser Ile Lys Pro Arg Leu Gly Ala 
            500                 505                 510         


Asp Glu Asp Ser Phe Val Ile Leu Glu Pro Glu Thr Asn Arg Glu Leu 
        515                 520                 525             


Glu Ala Leu Lys Gln Arg Phe Trp Lys His Ala Asn Pro Ala Ala Lys 
    530                 535                 540                 


Pro Arg Ala Gly Gln Thr Val Asn Val Asn Val Ile Val Lys Asp Met 
545                 550                 555                 560 


Gly Thr Asp Gly Lys Glu Glu Leu Lys Ala Asp Val Val Pro Val Thr 
                565                 570                 575     


Leu Ala Pro Lys Lys Leu Asp Gly Ala Ser His Thr Lys Pro Gly Glu 
            580                 585                 590         


Lys Leu Gln Val Leu Lys Ala Lys Leu Gln Glu Ala Met Lys Leu Arg 
        595                 600                 605             


Arg Phe Glu Glu Arg Gln Lys Arg Gln Ala Leu Phe Lys Leu Asp Asn 
    610                 615                 620                 


Glu Asp Gly Phe Glu Glu Glu Glu Glu Glu Glu Glu Glu Met Thr Asp 
625                 630                 635                 640 


Glu Ser Glu Glu Asp Gly Glu Glu Lys Val Glu Lys Glu Glu Lys Glu 
                645                 650                 655     


Glu Glu Leu Glu Glu Glu Glu Glu Lys Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gly Asn Gln Glu Thr Ala Glu Phe Leu Leu Ser Ser Glu Glu Ile Glu 
        675                 680                 685             


Thr Lys Asp Glu Lys Glu Met Asp Lys Glu Asn Asn Asp Gly Ser Ser 
    690                 695                 700                 


Glu Ile Gly Lys Ala Val Gly Phe Leu Ser Val Pro Lys Ser Leu Ser 
705                 710                 715                 720 


Ser Asp Ser Thr Leu Leu Leu Phe Lys Asp Ser Ser Ser Lys Met Gly 
                725                 730                 735     


Tyr Phe Pro Thr Glu Glu Lys Ser Glu Thr Asp Glu Asn Ser Gly Lys 
            740                 745                 750         


Gln Pro Ser Lys Leu Asp Glu Asp Asp Ser Cys Ser Leu Leu Thr Lys 
        755                 760                 765             


Glu Ser Ser His Asn Ser Ser Phe Glu Leu Ile Gly Ser Thr Ile Pro 
    770                 775                 780                 


Ser Tyr Gln Pro Cys Asn Arg Gln Thr Gly Arg Gly Thr Ser Phe Phe 
785                 790                 795                 800 


Pro Thr Ala Gly Gly Phe Arg Ser Pro Ser Pro Gly Leu Phe Arg Ala 
                805                 810                 815     


Ser Leu Val Ser Ser Ala Ser Lys Ser Ser Gly Lys Leu Ser Glu Pro 
            820                 825                 830         


Ser Leu Pro Ile Glu Asp Ser Gln Asp Leu Tyr Asn Ala Ser Pro Glu 
        835                 840                 845             


Pro Lys Thr Leu Phe Leu Gly Ala Gly Asp Phe Gln Phe Cys Leu Glu 
    850                 855                 860                 


Asp Asp Thr Gln Ser Gln Leu Leu Asp Ala Asp Gly Phe Leu Asn Val 
865                 870                 875                 880 


Arg Asn His Arg Asn Gln Tyr Gln Ala Leu Lys Pro Arg Leu Pro Leu 
                885                 890                 895     


Ala Ser Met Asp Glu Asn Ala Met Asp Ala Asn Met Asp Glu Leu Leu 
            900                 905                 910         


Asp Leu Cys Thr Gly Lys Phe Thr Ser Gln Ala Glu Lys His Leu Pro 
        915                 920                 925             


Arg Lys Ser Asp Lys Lys Glu Asn Met Glu Glu Leu Leu Asn Leu Cys 
    930                 935                 940                 


Ser Gly Lys Phe Thr Ser Gln Asp Ala Ser Thr Pro Ala Ser Ser Glu 
945                 950                 955                 960 


Leu Asn Lys Gln Glu Lys Glu Ser Ser Met Gly Asp Pro Met Glu Glu 
                965                 970                 975     


Ala Leu Ala Leu Cys Ser Gly Ser Phe Pro Thr Asp Lys Glu Glu Glu 
            980                 985                 990         


Asp Glu Glu Glu Glu Phe Gly Asp  Phe Arg Leu Val Ser  Asn Asp Asn 
        995                 1000                 1005             


Glu Phe  Asp Ser Asp Glu Asp  Glu His Ser Asp Ser  Gly Asn Asp 
    1010                 1015                 1020             


Leu Ala  Leu Glu Asp His Glu  Asp Asp Asp Glu Glu  Glu Leu Leu 
    1025                 1030                 1035             


Lys Arg  Ser Glu Lys Leu Lys  Arg Gln Met Arg Leu  Arg Lys Tyr 
    1040                 1045                 1050             


Leu Glu  Asp Glu Ala Glu Val  Ser Gly Ser Asp Val  Gly Ser Glu 
    1055                 1060                 1065             


Asp Glu  Tyr Asp Gly Glu Glu  Ile Asp Glu Tyr Glu  Glu Asp Val 
    1070                 1075                 1080             


Ile Asp  Glu Val Leu Pro Ser  Asp Glu Glu Leu Gln  Ser Gln Ile 
    1085                 1090                 1095             


Lys Lys  Ile His Met Lys Thr  Met Leu Asp Asp Asp  Lys Arg Gln 
    1100                 1105                 1110             


Leu Arg  Leu Tyr Gln Glu Arg  Tyr Leu Ala Asp Gly  Asp Leu His 
    1115                 1120                 1125             


Ser Asp  Gly Pro Gly Arg Met  Arg Lys Phe Arg Trp  Lys Asn Ile 
    1130                 1135                 1140             


Asp Asp  Ala Ser Gln Met Asp  Leu Phe His Arg Asp  Ser Asp Asp 
    1145                 1150                 1155             


Asp Gln  Thr Glu Glu Gln Leu  Asp Glu Ser Glu Ala  Arg Trp Arg 
    1160                 1165                 1170             


Lys Glu  Arg Ile Glu Arg Glu  Gln Trp Leu Arg Asp  Met Ala Gln 
    1175                 1180                 1185             


Gln Gly  Lys Ile Thr Ala Glu  Glu Glu Glu Glu Ile  Gly Glu Asp 
    1190                 1195                 1200             


Ser Gln  Phe Met Ile Leu Ala  Lys Lys Val Thr Ala  Lys Ala Leu 
    1205                 1210                 1215             


Gln Lys  Asn Ala Ser Arg Pro  Met Val Ile Gln Glu  Ser Lys Ser 
    1220                 1225                 1230             


Leu Leu  Arg Asn Pro Phe Glu  Ala Ile Arg Pro Gly  Ser Ala Gln 
    1235                 1240                 1245             


Gln Val  Lys Thr Gly Ser Leu  Leu Asn Gln Pro Lys  Ala Val Leu 
    1250                 1255                 1260             


Gln Lys  Leu Ala Ala Leu Ser  Asp His Asn Pro Ser  Ala Pro Arg 
    1265                 1270                 1275             


Asn Ser  Arg Asn Phe Val Phe  His Thr Leu Ser Pro  Val Lys Ala 
    1280                 1285                 1290             


Glu Ala  Ala Lys Glu Ser Ser  Lys Ser Gln Val Lys  Lys Arg Gly 
    1295                 1300                 1305             


Pro Ser  Phe Met Thr Ser Pro  Ser Pro Lys His Leu  Lys Thr Asp 
    1310                 1315                 1320             


Asp Ser  Thr Ser Gly Leu Thr  Arg Ser Ile Phe Lys  Tyr Leu Glu 
    1325                 1330                 1335             


Ser 
    


<210>  5907
<211>  571
<212>  DNA
<213>  Homosapiens

<400>  5907
gctttcaaca acttatttat tgattcattg atttacattt tagggaagag gaagacgagg     60

aggaggaatt tggagacttt cggcttgttt caaatgataa tgagtttgat agtgatgagg    120

tgagtatgaa gggaacaaag taatcataac tgagctccat gtattgctgc cctcaagtgt    180

ttttttcccc tcagttcttg agaattctaa gtttggcatc ttatcagaaa caatttccta    240

gaatgaggta tttgggcaga tgtttataaa tccttttttc attgaggacg cattttattc    300

tgcttaattt ggatatgatg ctgattttgt aggatgaaca cagtgactct ggtaatgatc    360

tggcactgga agaccatgaa gatgatgatg aagaagaact cctgaagcga tctgagaagt    420

tgaaaaggca aatgaggttg aggaaatacc tggaggatga ggcagaggtg tcaggaagtg    480

atgtgggaag cgaagatgag tatgatgggg aagaaattga tgaatatgaa gaggacgtaa    540

ttgatgaagt acttccttct gatgaggaac t                                   571


<210>  5908
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  5908

Met Arg Leu Arg Lys Tyr Leu Glu Asp Glu Ala Glu Val Ser Gly Ser 
1               5                   10                  15      


Asp Val Gly Ser Glu Asp Glu Tyr Asp Gly Glu Glu Ile Asp Glu Tyr 
            20                  25                  30          


Glu Glu Asp Val Ile Asp Glu Val Leu Pro Ser Asp Glu 
        35                  40                  45  


<210>  5909
<211>  461
<212>  DNA
<213>  Homosapiens

<400>  5909
ttgcaggctg actactgatc tcaaaccaag cacagactga gacaggctgt atagctcagc     60

cattgctttc tttctccttt acccaaaatt aaataataac tcaagttgct gggcatggtg    120

gctcatgcct gtaatcccag cactgttttt gtttaaatta catatacata tgtgcaaaga    180

agagagttta aaaggataca cgatatggtt atagaacctg tctctgatag aagattaagt    240

ttttcattta ttctatatat ttgtctataa tggggttttt tataataaga caaatgatat    300

ctaaaaaaaa aataaagcca gcttgtccac cccacacctc taggtgtgct acacgtgaat    360

catgccagag atactgctct gcaaagcctc caaggaaaaa gattctataa cttttcatta    420

taaggttttc aatagccttg aagatctgtt agaatacaaa g                        461


<210>  5910
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  5910

Met Gly Phe Phe Ile Ile Arg Gln Met Ile Ser Lys Lys Lys Ile Lys 
1               5                   10                  15      


Pro Ala Cys Pro Pro His Thr Ser Arg Cys Ala Thr Arg Glu Ser Cys 
            20                  25                  30          


Gln Arg Tyr Cys Ser Ala Lys Pro Pro Arg Lys Lys Ile Leu 
        35                  40                  45      


<210>  5911
<211>  384
<212>  DNA
<213>  Homosapiens

<400>  5911
acagcactgc tgggctggag acggcgggag ccgctgctct ccggctgagg gaatcagaga     60

cagctccgtc cctagtggag cgcaggggag gcagaagtca tgacaggcga ggtgggttct    120

gaggttcacc tagaaatcaa tgacccaaac gtcatttcac aagaggaagc agatagtcct    180

tcagatagtg gacagggcag ctatgaaaca attggaccct tgagtgaagg agattcagat    240

gaagagatat ttgtaagtaa gaagttgaaa aacaggaagg ttctacaaga cagtgattcc    300

gaaacagagg acacaaatgc ctctccagag aaaactacct atgacagtgc cgaggaggaa    360

aataaagaga atttatatgc tggg                                           384


<210>  5912
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  5912

Met Thr Gly Glu Val Gly Ser Glu Val His Leu Glu Ile Asn Asp Pro 
1               5                   10                  15      


Asn Val Ile Ser Gln Glu Glu Ala Asp Ser Pro Ser Asp Ser Gly Gln 
            20                  25                  30          


Gly Ser Tyr Glu Thr Ile Gly Pro Leu Ser Glu Gly Asp Ser Asp Glu 
        35                  40                  45              


Glu Ile Phe Val Ser Lys Lys Leu Lys Asn Arg Lys Val Leu Gln Asp 
    50                  55                  60                  


Ser Asp Ser Glu Thr Glu Asp Thr Asn Ala Ser Pro Glu Lys Thr Thr 
65                  70                  75                  80  


Tyr Asp Ser Ala Glu Glu Glu Asn Lys Glu Asn Leu Tyr Ala 
                85                  90                  


<210>  5913
<211>  7111
<212>  DNA
<213>  Homosapiens

<400>  5913
ggcggcggcg gcggcggcgg ggattgtttt tgttgtcgct gaggccggaa gagccggagc     60

cgggtccctg tccccgggcc gggcgccgcc gccgccccct gcccagcgcc cgcgtctccg    120

cggcgccacc ccagcgccaa tattccggag atcaagcgtt acgcggcggc ggcggcggcg    180

gcggcggggc ccggagcggg aggcgccggg gaccggggcg aggcggcccc cgccgccgcc    240

atggaggcgc tgggacccgg acctccggct agcctgtttc agccacctcg tcgtcctggc    300

cttggaactg ttggaaaacc aattcgactg ttagccaatc attttcaggt tcagattcct    360

aaaatagatg tgtatcacta tgatgtggat attaagcctg aaaaacggcc tcgtagagtc    420

aacagggagg tagtagatac aatggtgcgg cacttcaaga tgcaaatatt tggtgatcgg    480

cagcctgggt atgatggcaa aagaaacatg tacacagcac atccactacc aattggacgg    540

gatagggttg atatggaggt gactcttcca ggcgagggta aagaccaaac atttaaagtg    600

tctgttcagt gggtgtcagt tgtgagcctt cagttgcttt tagaagcttt ggctgggcac    660

ttgaatgaag tcccagatga ctcagtacaa gcacttgatg ttatcacaag acaccttccc    720

tccatgaggt acaccccagt gggccgttcc tttttctcac ccccggaagg ttactaccac    780

cctctgggag ggggcaggga ggtctggttt ggttttcatc agtctgtgag acctgccatg    840

tggaatatga tgctcaacat tgatgtatct gcaactgctt tctaccgggc tcagcctatc    900

attgagttca tgtgtgaggt tttagacatt cagaacatca atgaacagac caaacctcta    960

acagactccc agcgtgtcaa atttaccaaa gaaatcagag gtctcaaagt tgaggtgacc   1020

cactgtggac agatgaaacg aaaataccga gtttgtaatg tgactagacg gccagccagt   1080

catcaaactt ttcctttgca gctagaaaac ggtcaagcta tggaatgtac agtagctcaa   1140

tattttaagc aaaagtatag tctgcaactg aaataccccc atcttccctg tctccaagtg   1200

ggacaagaac aaaagcatac atacttgcca ctcgaggtct gtaatatagt ggcaggacag   1260

cgatgtatca agaagctcac agacaatcag acttccacaa tgatcaaagc tacagcaaga   1320

tctgctcctg acagacagga agagatcagt agactggtga agagcaacag tatggtgggt   1380

ggacctgatc cataccttaa agaatttggt attgttgtcc acaatgaaat gacagagctc   1440

acaggcaggg tacttccagc accaatgctg caatatggag gccggaataa aacagtagcc   1500

acacccaacc agggtgtctg ggacatgcga ggaaagcagt tttatgctgg cattgaaatt   1560

aaagtttggg cagttgcttg ttttgcacct cagaaacaat gtagggaaga tttactaaag   1620

agtttcactg accagctgcg taaaatctct aaggatgcag gaatgcccat ccagggtcag   1680

ccatgtttct gcaagtatgc acaaggtgca gacagtgtgg agcctatgtt taaacatctg   1740

aaaatgactt atgtgggcct acagctaata gtggttatcc tgcctggaaa gacaccagta   1800

tatgcggagg tgaaacgtgt tggagatacc cttctaggta tggccacaca gtgtgtccag   1860

gtaaaaaatg tagtgaagac ctcacctcaa accctttcca atctttgcct gaagataaat   1920

gcaaaacttg gaggaattaa caatgtgctt gtgcctcatc aaaggccctc ggtgttccag   1980

cagcctgtca tcttcctggg agcggatgtc acacaccccc cagcagggga tgggaagaaa   2040

ccttccattg ctgctgtggt tggcagtatg gatggccacc ccagccggta ctgtgccacc   2100

gttcgggtgc agacttcccg gcaggagatc tcccaagagc tcctctacag tcaagaggtc   2160

atccaggacc tgactaacat ggttcgagag ctgctgattc agttctacaa atccacacgc   2220

ttcaaaccca ctcggatcat ctattaccgt ggaggggtat ctgagggaca aatgaaacag   2280

gtagcttggc cagaactaat agcaattcga aaggcatgta ttagcttgga agaagattac   2340

cggccaggaa taacttatat tgtggtgcaa aaaagacatc acacacgact cttctgtgca   2400

gataaaacag aaagggtagg gaaaagtggc aatgtaccag caggcactac agtggatagt   2460

accatcacac atccatctga gtttgacttt tacctctgta gtcatgcagg aattcaggga   2520

accagccgtc cctcacatta ccaggtcttg tgggatgaca actgcttcac tgcagatgaa   2580

ctccagctac tgacttacca gctgtgtcac acctatgtga ggtgcactcg ctcagtctct   2640

attccagccc ctgcatatta tgcccggctt gtagcattta gggcaaggta tcatctggtg   2700

gataaagatc atgacagtgc ggaaggcagt catgtgtcag gacagagcaa cggccgggat   2760

cctcaggcct tggctaaggc tgtgcaaatc caccatgata cccagcacac gatgtatttt   2820

gcctgagagt ctcagaaaaa gaactcaacc aatttggcac cccatgcagc ctcaaaatgt   2880

ttcaaatgcc taccgcctct agatcgagcc acgttgactt caggtggtct tctaccagca   2940

gctcggaata gttgcactga atctatactt tgcagcactg tctgatgcgt caacaaaatt   3000

gagccatttt tttaaagtaa tagatactaa tagattatct tttctgatgc actggactga   3060

atttttacct caatgtgcaa aggctgatca gcctgaactt tctaaaggac tttacaagaa   3120

gggtttctat ggaatatttt gctagctgtg gtgttcaccg catccctcta gtcttagaag   3180

agaagattat tccttttttc tgtagtcatt gagtggggta tatgcataag tgggagagaa   3240

aaaccaaaca atctacttca gttcagtgta actatttaat tgtgtgggtc catagacttt   3300

ttaatgaaga tttctgactt tgccactgta aatgccttta atgagcatta atttttgaaa   3360

gttttacaga gttttattag ttttactact ttatcttatt gatctctgca gacttgtgct   3420

ggtgcaagta catgctgaca ggcaatttgc actatatttg gctgcagatt caaataggca   3480

gttctcttat ttggtcgact tttgtgaatg tgtgacataa acagatgtaa tgcatgtcac   3540

agtgacggag ataacactgc catgataaaa gtactcatgt ttcccctatt tggaaaaaaa   3600

aattgctttt agtatttttc caagttttca aaagtgccca ttttatgctg ctgtgtggtt   3660

tgttaaatct aaatgatttt taaacttttc tcatagaaac ttaactttgg caataaacat   3720

tttttaaggt ctctcctctt ccttccccaa caatgtagtt ttctagatga gatttcagta   3780

tgattttatc agctatttct tatatatcat aatctggcaa tttctgaaac cagtcagaaa   3840

agacatatat ttccatgcct ttttaaagaa ttatttttac ctgttttata ttcacagttg   3900

gtgtcctgtc actttgtttt aaaataagct agaaccagga tgcttcctta ttggaaaggc   3960

tttgccagtc cttaaggtac aatgagtgat gctgcaactt gcaaatgtac cagcatttaa   4020

aatttctttt cctgggaatc aaggtaactc acacgactac ttgcagtaca aattttttgc   4080

ttctctttcg acatgaaatg tacttggtgg gttttccttc cttttattaa actaaaactg   4140

tgtggaaaag gttgattttt cttaatagat tctggattcc actcacaggg agatgggatt   4200

cctttcttgt ccaaacaaag ggagttgctc taaagcgagc atcagttaaa atgtagggga   4260

aaatgtattc tgtatgtagt gtagataata ctttgtgaat ggacaacagt tacatagtgt   4320

cttggtagca ccagccagtg tttcccagcc cagagtttac tgacttgtaa ttctctatcc   4380

aggacatcag gagtgaggga tggaaaaggg gataaaaggc ctggagccac actctatatg   4440

gctgaggaag gagctaggga aagagataga cacaatgggg tgaaaacaat tttgccgccc   4500

ctgcctggaa actgctggtg gggaaatgat ggtgaagggt gtttgcttga actcatgaga   4560

cggtccaaat ctcataaact agccttctca aaatcccagc aatataaagc actgtttttc   4620

ttcagtcgtt taaataaact tgtaaataca ttgaagttta catttccatg tgctgttgat   4680

caacggcgcc acctgtgttt gctgagactg gtctctgaga gagttttatg tcgatcgagg   4740

cctgttgctc attaagctga gtgcagacgt ccttaatccc tgcagatagt gggatgaaag   4800

caagttctgt aaaatgaagc acaacatagc caggagtgaa gagatggcag atgttaattt   4860

cttaaaattt tccttttttt tttttttttt tgcaaatacc tcacttggat aatacaaatc   4920

aggacatgtt ggtgaggggc tggctgcttg gctgctgctt ttattcacac ttgttcaggg   4980

agagcacaga gaataccctt cagcatggcc actctggacc caagaggagg aaaaaacgga   5040

agctttttta ggagaaggag gacttgctgg aatccaagat gtgaagaact cttggtgact   5100

ggctggctgg ccagcgggca ccacacctgc acttgagtgc ctcgggcttg cttattaata   5160

acgcacagaa gaagcatcac ttctcaccat ctcctggcat gtatggagca gggagcaagg   5220

ctatgttccc gaaagccctg attagcttgt cttgctctac gctcgacctc gaacaataca   5280

gcttgtaaga cctcagtcag tcctggtaca ctggggtaaa tcagtgtggt ggtggaagaa   5340

aagccgggag gcctattttt ataggaaaat agtaccatta aaggtgcaat gctgtcattt   5400

tggacaaaag gaaagaaatt tggaagagct gggattattg gcaaaaactt gctgaggggt   5460

gaatctttag agctaatcac tgcagaatca gagttgcagc aatatgattg caagcaagtc   5520

tgaatgcata gttttacttt aattcggctt gacaatttga ataggtaacc ccctcgggac   5580

tgactgaatc gttatgcatg tgtcaatcaa tgggaggtgt gcattctcta gaagtagttt   5640

taggctgttt ggtttggttt tggttttgtt ttttaaatgc agcctgttga ggcactgtca   5700

tgtggtgtga aagatttaaa tgtagcaacg ctaaagagta ataatttggg gataagaagt   5760

ggggacattg gccgggcgcg gtggctcacg cctgtaattc cagcactttg ggaggcctag   5820

gtgggcggat cagctgaggt cgagagttcg aggccagtct gaccaacatg gtgaaacccc   5880

atctctacta aaaatacaga aaattagctg ggtctggtgg tggatgcctg taatcccagc   5940

tactcgggag gctgaggcag gagaattgct tgaacccagg aggtggacgg tgcagtgagc   6000

tattactcca gcctgggcaa caagagcgaa actctgtctc aaaaaaaaaa aggggggggg   6060

gggacattaa gagagtggtg atgacccaaa tgttgaacca attatgtttt ggtggtggtg   6120

ttcttagctg ttgaatcctg aatggtttat aaagtgaact agctggctta atgcagccag   6180

cgttctgggc agcagaacat attcattctt actgtaaatt ctatttgctg cttccaaagg   6240

tgatgatttt caagcagaca tgttctatat ggtctgtgtt ttaggatctg gtgcccagcc   6300

tctatcagag cttgcctacc tggcaaagct gcctaccctt caagtgggaa aatataatcc   6360

actgtttaac aaggctcacc ctctccaccc tgtcctaacg accttttgtg aatgtgctgt   6420

gatattttct tgctcaatag caaggtggta gctctgcttt cattttaaga aagtggaggc   6480

tgagggcatt gtatcaatac tgttgcaact ccaagaagtt ttccttgtaa aattaaagga   6540

aagatcttgt tattgattaa ccattttctt atgccttgct attgacatat tcatgctctt   6600

tctacgtcta gtggctgaaa atgtttgcat ttgttcattt gactaatggt gtgatttttg   6660

tttctatatt attagacctg taatgtttta aaatgtattt tattaaattt ggactggatg   6720

tatgtctcta gcaatacgag gtactttcta aactattaag ggaggggttg tatcctcatg   6780

ttgagataag atgatggtcg tttaaatttt gcaatttttt ttggcctgca gggatatttt   6840

gtgtttatgt gtccaaaaaa ggaataaatt ggcattcttg tgccaaaagt tgtttttcct   6900

gtcaattgtc taataagtat gcagtacact gtaatggcaa catacatggt tgctttataa   6960

aaacagtttc ctcagtatga gaaattttac aaagaacagt ggaaaaactt tgtgttttta   7020

actcttgggt ctccctattt ttaaaaattg ctatttggta tacaattatt atgtgtcaat   7080

taaaactaaa ataaaacttt taaaaaagaa a                                  7111


<210>  5914
<211>  861
<212>  PRT
<213>  Homosapiens

<400>  5914

Met Glu Ala Leu Gly Pro Gly Pro Pro Ala Ser Leu Phe Gln Pro Pro 
1               5                   10                  15      


Arg Arg Pro Gly Leu Gly Thr Val Gly Lys Pro Ile Arg Leu Leu Ala 
            20                  25                  30          


Asn His Phe Gln Val Gln Ile Pro Lys Ile Asp Val Tyr His Tyr Asp 
        35                  40                  45              


Val Asp Ile Lys Pro Glu Lys Arg Pro Arg Arg Val Asn Arg Glu Val 
    50                  55                  60                  


Val Asp Thr Met Val Arg His Phe Lys Met Gln Ile Phe Gly Asp Arg 
65                  70                  75                  80  


Gln Pro Gly Tyr Asp Gly Lys Arg Asn Met Tyr Thr Ala His Pro Leu 
                85                  90                  95      


Pro Ile Gly Arg Asp Arg Val Asp Met Glu Val Thr Leu Pro Gly Glu 
            100                 105                 110         


Gly Lys Asp Gln Thr Phe Lys Val Ser Val Gln Trp Val Ser Val Val 
        115                 120                 125             


Ser Leu Gln Leu Leu Leu Glu Ala Leu Ala Gly His Leu Asn Glu Val 
    130                 135                 140                 


Pro Asp Asp Ser Val Gln Ala Leu Asp Val Ile Thr Arg His Leu Pro 
145                 150                 155                 160 


Ser Met Arg Tyr Thr Pro Val Gly Arg Ser Phe Phe Ser Pro Pro Glu 
                165                 170                 175     


Gly Tyr Tyr His Pro Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe 
            180                 185                 190         


His Gln Ser Val Arg Pro Ala Met Trp Asn Met Met Leu Asn Ile Asp 
        195                 200                 205             


Val Ser Ala Thr Ala Phe Tyr Arg Ala Gln Pro Ile Ile Glu Phe Met 
    210                 215                 220                 


Cys Glu Val Leu Asp Ile Gln Asn Ile Asn Glu Gln Thr Lys Pro Leu 
225                 230                 235                 240 


Thr Asp Ser Gln Arg Val Lys Phe Thr Lys Glu Ile Arg Gly Leu Lys 
                245                 250                 255     


Val Glu Val Thr His Cys Gly Gln Met Lys Arg Lys Tyr Arg Val Cys 
            260                 265                 270         


Asn Val Thr Arg Arg Pro Ala Ser His Gln Thr Phe Pro Leu Gln Leu 
        275                 280                 285             


Glu Asn Gly Gln Ala Met Glu Cys Thr Val Ala Gln Tyr Phe Lys Gln 
    290                 295                 300                 


Lys Tyr Ser Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val 
305                 310                 315                 320 


Gly Gln Glu Gln Lys His Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile 
                325                 330                 335     


Val Ala Gly Gln Arg Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser 
            340                 345                 350         


Thr Met Ile Lys Ala Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu 
        355                 360                 365             


Ile Ser Arg Leu Val Lys Ser Asn Ser Met Val Gly Gly Pro Asp Pro 
    370                 375                 380                 


Tyr Leu Lys Glu Phe Gly Ile Val Val His Asn Glu Met Thr Glu Leu 
385                 390                 395                 400 


Thr Gly Arg Val Leu Pro Ala Pro Met Leu Gln Tyr Gly Gly Arg Asn 
                405                 410                 415     


Lys Thr Val Ala Thr Pro Asn Gln Gly Val Trp Asp Met Arg Gly Lys 
            420                 425                 430         


Gln Phe Tyr Ala Gly Ile Glu Ile Lys Val Trp Ala Val Ala Cys Phe 
        435                 440                 445             


Ala Pro Gln Lys Gln Cys Arg Glu Asp Leu Leu Lys Ser Phe Thr Asp 
    450                 455                 460                 


Gln Leu Arg Lys Ile Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln 
465                 470                 475                 480 


Pro Cys Phe Cys Lys Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met 
                485                 490                 495     


Phe Lys His Leu Lys Met Thr Tyr Val Gly Leu Gln Leu Ile Val Val 
            500                 505                 510         


Ile Leu Pro Gly Lys Thr Pro Val Tyr Ala Glu Val Lys Arg Val Gly 
        515                 520                 525             


Asp Thr Leu Leu Gly Met Ala Thr Gln Cys Val Gln Val Lys Asn Val 
    530                 535                 540                 


Val Lys Thr Ser Pro Gln Thr Leu Ser Asn Leu Cys Leu Lys Ile Asn 
545                 550                 555                 560 


Ala Lys Leu Gly Gly Ile Asn Asn Val Leu Val Pro His Gln Arg Pro 
                565                 570                 575     


Ser Val Phe Gln Gln Pro Val Ile Phe Leu Gly Ala Asp Val Thr His 
            580                 585                 590         


Pro Pro Ala Gly Asp Gly Lys Lys Pro Ser Ile Ala Ala Val Val Gly 
        595                 600                 605             


Ser Met Asp Gly His Pro Ser Arg Tyr Cys Ala Thr Val Arg Val Gln 
    610                 615                 620                 


Thr Ser Arg Gln Glu Ile Ser Gln Glu Leu Leu Tyr Ser Gln Glu Val 
625                 630                 635                 640 


Ile Gln Asp Leu Thr Asn Met Val Arg Glu Leu Leu Ile Gln Phe Tyr 
                645                 650                 655     


Lys Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile Tyr Tyr Arg Gly Gly 
            660                 665                 670         


Val Ser Glu Gly Gln Met Lys Gln Val Ala Trp Pro Glu Leu Ile Ala 
        675                 680                 685             


Ile Arg Lys Ala Cys Ile Ser Leu Glu Glu Asp Tyr Arg Pro Gly Ile 
    690                 695                 700                 


Thr Tyr Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys Ala 
705                 710                 715                 720 


Asp Lys Thr Glu Arg Val Gly Lys Ser Gly Asn Val Pro Ala Gly Thr 
                725                 730                 735     


Thr Val Asp Ser Thr Ile Thr His Pro Ser Glu Phe Asp Phe Tyr Leu 
            740                 745                 750         


Cys Ser His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr Gln 
        755                 760                 765             


Val Leu Trp Asp Asp Asn Cys Phe Thr Ala Asp Glu Leu Gln Leu Leu 
    770                 775                 780                 


Thr Tyr Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser 
785                 790                 795                 800 


Ile Pro Ala Pro Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala Arg 
                805                 810                 815     


Tyr His Leu Val Asp Lys Asp His Asp Ser Ala Glu Gly Ser His Val 
            820                 825                 830         


Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val 
        835                 840                 845             


Gln Ile His His Asp Thr Gln His Thr Met Tyr Phe Ala 
    850                 855                 860     


<210>  5915
<211>  839
<212>  DNA
<213>  Homosapiens

<400>  5915
caacatggtg aaaccctgtc tctactaaaa atacaaaaat tagctgggca tggtggcagg     60

catgtaatcc caacactttg ggaggctgag gaaagagaat tgcttgagcc caagtggtgg    120

aggtttcagt aagccaaaat catgccactg cactccagcc taggtgacag aacgagactc    180

tgtctcaaaa aaaaaaaaaa aaaaagcaag attaaagtta ttattgtact aagtatttga    240

gataatttgc ccactggaaa agccaaatag agtatcttaa ttatgccaaa tattctggca    300

cagtctcaga ttcatgtatt tggtcttgtt gtctccagat ccacatgtat ttgttctagt    360

tttaggatct aaaaatttgg gaatctaaaa atgtggcccc aataactatg ctacactcat    420

tttacataaa gttatcttaa gggaacaaaa cacctacatg gattactcca aatctttatg    480

ttaatttgaa gccagcaaga ggttgtattt gtacctgtag gtgttacctg acctcaagtg    540

agtctatgta tgttctggtt ctgcagtatc ttcttgtttt aagttatttt tttaaaattc    600

ttcttaaatt ttaatttaaa aaaatttctc atccaagctt taaccaacat ggaaaatttc    660

aatggaatca ttgttctggt taaatactaa acttacttaa gtgaaaatgc tcaaataaag    720

attaactttt gttttttggc tgggcatgtg gctcacacct gtgatcccag cactttggga    780

ggatgaggca ggtggatcac ctgaagtcgg gagttctaga tcagcctggc caatgcggt     839


<210>  5916
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  5916

Met Pro Leu His Ser Ser Leu Gly Asp Arg Thr Arg Leu Cys Leu Lys 
1               5                   10                  15      


Lys Lys Lys Lys Lys Ser Lys Ile Lys Val Ile Ile Val Leu Ser Ile 
            20                  25                  30          


<210>  5917
<211>  799
<212>  DNA
<213>  Homosapiens

<400>  5917
catggtgact cacgcctgta atcccagcac tttggaaggc tgaggcaggc agatcacttg     60

aggtcaggag tttgagacca gactggccaa catggtgaaa ccctgtctct actaaaaaat    120

acaaaaatta gccaggtgtg gtggtgtgtg cctgtaatcc cagctactca gaaggtggaa    180

gaggcaggag aatcacttga accaggaagg tggaggttgc agtgagccaa gatcacacca    240

agctaggaga ggaaaagctg caatccaaac caaagaagtt taacgccaaa gtatgcactc    300

taagccacta cactatattg tctcaaatgt ttgggttaaa attaaatgaa gacagacttt    360

aggttaactt cccctatggc ccatatatct catcactaat gtttaaggag ggatttattt    420

acctagaagt ttcatccaag gacaaaaatg agaactgtgt tgggaggctg agcgggtgga    480

ttgcttgagc tcaggagttt gagaccagtg tgggcaacat ggagaaacct cgtctgtatg    540

aaaaatacaa aaaataagcc aggcgtggtg gtgcacacct gtggtcccag ctagttggga    600

ggctgaggtg ggaagattgc ttgagcctgg gaggcggagt ttgcagtgag ccgagattgt    660

gccaccgcac tccagcctgg gtgacaaagt gagacactgt ctcaaaaaaa taaataaata    720

agaaataaga aatcaactaa tcaagttgac aaaatatgct aagattaaat taaaaaaaaa    780

agagaactgt gatatgatt                                                 799


<210>  5918
<211>  41
<212>  PRT
<213>  Homosapiens

<400>  5918

Ser Gln Leu Leu Arg Arg Trp Lys Arg Gln Glu Asn His Leu Asn Gln 
1               5                   10                  15      


Glu Gly Gly Gly Cys Ser Glu Pro Arg Ser His Gln Ala Arg Arg Gly 
            20                  25                  30          


Lys Ala Ala Ile Gln Thr Lys Glu Val 
        35                  40      


<210>  5919
<211>  966
<212>  DNA
<213>  Homosapiens

<400>  5919
acagtgcgga aggcagtcat gtgtcaggac agagcaacgg ccgggatcct caggccttgg     60

ctaaggctgt gcaaatccac catgataccc agcacacgat gtattttgcc tgagagtctc    120

agaaaaagaa ctcaaccaat ttggcacccc atgcagcctc aaaatgtttc aaatgcctac    180

cgcctctaga tcgagccacg ttgacttcag ttggtgtcct gtcactttgt tttaaaataa    240

gctagaacca ggatgcttcc ttattggaaa ggctttgcca gtccttaagg tacaatgagt    300

gatgctgcaa cttgcaaatg taccagcatt taaaatttct tttcctggga atcaaggtaa    360

ctcacacgac tacttgcagt acaaattttt tgcttctctt tcgacatgaa atgtacttgg    420

tgggttttcc ttccttttat taaactaaaa ctgtgtggaa aaggttgatt tttcttaata    480

gattctggat tccactcaca gggagatggg attcctttct tgtccaaaca aagggagttg    540

ctctaaagcg agcatcagtt aaaatgtagg ggaaaatgta ttctgtatgt agtgtagata    600

atactttgtg aatggacaac agttacatag tgtcttggta gcaccagcca gtgtttccca    660

gcccagagtt tactgacttg taattctcta tccaggacat caggagtgag ggatggaaaa    720

ggggataaaa ggcctggagc cacactctat atggctgagg aaggagctag ggaaagagat    780

agacacaatg gggtgaaaac aattttgccg cccctgcctg gaaactgctg gtggggaaat    840

gatggtgaag ggtgtttgct tgaactcatg agacggtcca aatctcataa actagccttc    900

tcaaaatccc agcaatataa agcactgttt ttcttcagtc gtttaaataa acttgtaaat    960

acattg                                                               966


<210>  5920
<211>  71
<212>  PRT
<213>  Homosapiens

<400>  5920

Met Ala Glu Glu Gly Ala Arg Glu Arg Asp Arg His Asn Gly Val Lys 
1               5                   10                  15      


Thr Ile Leu Pro Pro Leu Pro Gly Asn Cys Trp Trp Gly Asn Asp Gly 
            20                  25                  30          


Glu Gly Cys Leu Leu Glu Leu Met Arg Arg Ser Lys Ser His Lys Leu 
        35                  40                  45              


Ala Phe Ser Lys Ser Gln Gln Tyr Lys Ala Leu Phe Phe Phe Ser Arg 
    50                  55                  60                  


Leu Asn Lys Leu Val Asn Thr 
65                  70      


<210>  5921
<211>  3424
<212>  DNA
<213>  Homosapiens

<400>  5921
acagtgcgga aggcagtcat gtgtcaggac agagcaacgg ccgggatcct caggccttgg     60

ctaaggctgt gcaaatccac catgataccc agcacacgat gtattttgcc tgagagtctc    120

agaaaaagaa ctcaaccaat ttggcacccc atgcagcctc aaaatgtttc aaatgcctac    180

cgcctctaga tcgagccacg ttgacttcag ttggtgtcct gtcactttgt tttaaaataa    240

gctagaacca ggatgcttcc ttattggaaa ggctttgcca gtccttaagg tacaatgagt    300

gatgctgcaa cttgcaaatg taccagcatt taaaatttct tttcctggga atcaaggtaa    360

ctcacacgac tacttgcagt acaaattttt tgcttctctt tcgacatgaa atgtacttgg    420

tgggttttcc ttccttttat taaactaaaa ctgtgtggaa aaggttgatt tttcttaata    480

gattctggat tccactcaca gggagatggg attcctttct tgtccaaaca aagggagttg    540

ctctaaagcg agcatcagtt aaaatgtagg ggaaaatgta ttctgtatgt agtgtagata    600

atactttgtg aatggacaac agttacatag tgtcttggta gcaccagcca gtgtttccca    660

gcccagagtt tactgacttg taattctcta tccaggacat caggagtgag ggatggaaaa    720

ggggataaaa ggcctggagc cacactctat atggctgagg aaggagctag ggaaagagat    780

agacacaatg gggtgaaaac aattttgccg cccctgcctg gaaactgctg gtggggaaat    840

gatggtgaag ggtgtttgct tgaactcatg agacggtcca aatctcataa actagccttc    900

tcaaaatccc agcaatataa agcactgttt ttcttcagtc gtttaaataa acttgtaaat    960

acattgaagt ttacatttcc atgtgctgtt gatcaacggc gccacctgtg tttgctgaga   1020

ctggtctctg agagagtttt atgtcgatcg aggcctgttg ctcattaagc tgagtgcaga   1080

cgtccttaat ccctgcagat agtgggatga aagcaagttc tgtaaaatga agcacaacat   1140

agccaggagt gaagagatgg cagatgttaa tttcttaaaa ttttcctttt tttttttttt   1200

ttttgcaaat acctcacttg gataatacaa atcaggacat gttggtgagg ggctggctgc   1260

ttggctgctg cttttattca cacttgttca gggagagcac agagaatacc cttcagcatg   1320

gccactctgg acccaagagg aggaaaaaac ggaagctttt ttaggagaag gaggacttgc   1380

tggaatccaa gatgtgaaga actcttggtg actggctggc tggccagcgg gcaccacacc   1440

tgcacttgag tgcctcgggc ttgcttatta ataacgcaca gaagaagcat cacttctcac   1500

catctcctgg catgtatgga gcagggagca aggctatgtt cccgaaagcc ctgattagct   1560

tgtcttgctc tacgctcgac ctcgaacaat acagcttgta agacctcagt cagtcctggt   1620

acactggggt aaatcagtgt ggtggtggaa gaaaagccgg gaggcctatt tttataggaa   1680

aatagtacca ttaaaggtgc aatgctgtca ttttggacaa aaggaaagaa atttggaaga   1740

gctgggatta ttggcaaaaa cttgctgagg ggtgaatctt tagagctaat cactgcagaa   1800

tcagagttgc agcaatatga ttgcaagcaa gtctgaatgc atagttttac tttaattcgg   1860

cttgacaatt tgaataggta accccctcgg gactgactga atcgttatgc atgtgtcaat   1920

caatgggagg tgtgcattct ctagaagtag ttttaggctg tttggtttgg ttttggtttt   1980

gttttttaaa tgcagcctgt tgaggcactg tcatgtggtg tgaaagattt aaatgtagca   2040

acgctaaaga gtaataattt ggggataaga agtggggaca ttggccgggc gcggtggctc   2100

acgcctgtaa ttccagcact ttgggaggcc taggtgggcg gatcagctga ggtcgagagt   2160

tcgaggccag tctgaccaac atggtgaaac cccatctcta ctaaaaatac agaaaattag   2220

ctgggtctgg tggtggatgc ctgtaatccc agctactcgg gaggctgagg caggagaatt   2280

gcttgaaccc aggaggtgga cggtgcagtg agctattact ccagcctggg caacaagagc   2340

gaaactctgt ctcaaaaaaa aaaagggggg ggggggacat taagagagtg gtgatgaccc   2400

aaatgttgaa ccaattatgt tttggtggtg gtgttcttag ctgttgaatc ctgaatggtt   2460

tataaagtga actagctggc ttaatgcagc cagcgttctg ggcagcagaa catattcatt   2520

cttactgtaa attctatttg ctgcttccaa aggtgatgat tttcaagcag acatgttcta   2580

tatggtctgt gttttaggat ctggtgccca gcctctatca gagcttgcct acctggcaaa   2640

gctgcctacc cttcaagtgg gaaaatataa tccactgttt aacaaggctc accctctcca   2700

ccctgtccta acgacctttt gtgaatgtgc tgtgatattt tcttgctcaa tagcaaggtg   2760

gtagctctgc tttcatttta agaaagtgga ggctgagggc attgtatcaa tactgttgca   2820

actccaagaa gttttccttg taaaattaaa ggaaagatct tgttattgat taaccatttt   2880

cttatgcctt gctattgaca tattcatgct ctttctacgt ctagtggctg aaaatgtttg   2940

catttgttca tttgactaat ggtgtgattt ttgtttctat attattagac ctgtaatgtt   3000

ttaaaatgta ttttattaaa tttggactgg atgtatgtct ctagcaatac gaggtacttt   3060

ctaaactatt aagggagggg ttgtatcctc atgttgagat aagatgatgg tcgtttaaat   3120

tttgcaattt tttttggcct gcagggatat tttgtgttta tgtgtccaaa aaaggaataa   3180

attggcattc ttgtgccaaa agttgttttt cctgtcaatt gtctaataag tatgcagtac   3240

actgtaatgg caacatacat ggttgcttta taaaaacagt ttcctcagta tgagaaattt   3300

tacaaagaac agtggaaaaa ctttgtgttt ttaactcttg ggtctcccta tttttaaaaa   3360

ttgctatttg gtatacaatt attatgtgtc aattaaaact aaaataaaac ttttaaaaaa   3420

gaaa                                                                3424


<210>  5922
<211>  105
<212>  PRT
<213>  Homosapiens

<400>  5922

Met Ala Glu Glu Gly Ala Arg Glu Arg Asp Arg His Asn Gly Val Lys 
1               5                   10                  15      


Thr Ile Leu Pro Pro Leu Pro Gly Asn Cys Trp Trp Gly Asn Asp Gly 
            20                  25                  30          


Glu Gly Cys Leu Leu Glu Leu Met Arg Arg Ser Lys Ser His Lys Leu 
        35                  40                  45              


Ala Phe Ser Lys Ser Gln Gln Tyr Lys Ala Leu Phe Phe Phe Ser Arg 
    50                  55                  60                  


Leu Asn Lys Leu Val Asn Thr Leu Lys Phe Thr Phe Pro Cys Ala Val 
65                  70                  75                  80  


Asp Gln Arg Arg His Leu Cys Leu Leu Arg Leu Val Ser Glu Arg Val 
                85                  90                  95      


Leu Cys Arg Ser Arg Pro Val Ala His 
            100                 105 


<210>  5923
<211>  562
<212>  DNA
<213>  Homosapiens

<400>  5923
gataggctgg gtcaaatgct ttcccttact ccttctttgg gagataggat ccctctttat     60

tatagaaaat ttgttgttgt tattattatt attattgaga tggaatctca ctctgtcacc    120

caggctagag tgcaatggcg aaattgagcc aagattgtgc tgctgcactc cagcctgggc    180

aacagaggga gactctgtct cacaaaacta acaaacaaac aaacaaaccc catggacaaa    240

tggataaaaa agaacaagtt gtcttagaaa tcaagggaaa agagcatttc atcaagtatg    300

tacaggatcg gctatgtagg agttagctgt gtgacactgg gcaagttaac ctctcttagc    360

ctcagttttc ttattcgtaa aatggagata gtactagtac ttacatccag ggttggaagg    420

attaaatgca atcatacatg taaaggcttg gaaacacata cacataagct acaaagaagg    480

aagtggctaa ctatccaata gtgatctaaa aagacaaaat ctgaaaagtt tccattggaa    540

tttgcagcaa ggaagttata gg                                             562


<210>  5924
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  5924

Met Ala Lys Leu Ser Gln Asp Cys Ala Ala Ala Leu Gln Pro Gly Gln 
1               5                   10                  15      


Gln Arg Glu Thr Leu Ser His Lys Thr Asn Lys Gln Thr Asn Lys Pro 
            20                  25                  30          


His Gly Gln Met Asp Lys Lys Glu Gln Val Val Leu Glu Ile Lys Gly 
        35                  40                  45              


Lys Glu His Phe Ile Lys Tyr Val Gln Asp Arg Leu Cys Arg Ser 
    50                  55                  60              


<210>  5925
<211>  3996
<212>  DNA
<213>  Homosapiens

<400>  5925
tgaggcaagc gcctcaggag tgcgtgaggc ccacgcagaa ctcggggagc cttttatcct     60

gaggacacag gggaagaatt ggaggactat attcagctgc gggcgcttac ctgccccccc    120

tgcagcaggt gttccaggca cctcgccggc ctggcattgg cactgtgggg aaaccaatca    180

agctcctggc caattacttt gaggtggaca tccctaagat cgacgtgtac cactacgagg    240

tggacatcaa gccggataag tgtccccgta gagtcaaccg ggaagtggtg gaatacatgg    300

tccagcattt caagcctcag atctttggtg atcgcaagcc tgtgtatgat ggaaagaaga    360

acatttacac tgtcacagca ctgcccattg gcaacgaacg ggtcgacttt gaggtgacaa    420

tccctgggga agggaaggat cgaatcttta aggtctccat caagtggcta gccattgtga    480

gctggcgaat gctgcatgag gccctggtca gcggccagat ccctgttccc ttggagtctg    540

tgcaagccct ggatgtggcc atgaggcacc tggcatccat gaggtacacc cctgtgggcc    600

gctccttctt ctcaccgcct gagggctact accacccgct ggggggtggg cgcgaggtct    660

ggttcggctt tcaccagtct gtgcgccctg ccatgtggaa gatgatgctc aacattgatg    720

tctcagccac tgccttttat aaggcacagc cagtgattga gttcatgtgt gaggtgctgg    780

acatcaggaa catagatgag cagcccaagc ccctcacgga ctctcagcgc gttcgcttca    840

ccaaggagat caagggcctg aaggtggaag tcacccactg tggacagatg aagaggaagt    900

accgcgtgtg taatgttacc cgtcgccctg ctagccatca gacattcccc ttacagctgg    960

agagtggaca gactgtggag tgcacagtgg cacagtattt caagcagaaa tataaccttc   1020

agctcaagta tccccatctg ccctgcctac aagttggcca ggaacaaaag catacctacc   1080

ttcccctaga ggtctgtaac attgtggctg ggcagcgctg tattaaaaag ctgaccgaca   1140

accagacctc gaccatgata aaggccacag ctagatccgc tccagacaga caggaggaga   1200

tcagtcgcct gatgaagaat gccagctaca acttagatcc ctacatccag gaatttggga   1260

tcaaagtgaa ggatgacatg acggaggtga cagggcgagt gctgccggcg cccatcttgc   1320

agtacggcgg ccggaaccgg gccattgcca cacccaatca gggtgtctgg gacatgcggg   1380

ggaaacagtt ctacaatggg attgagatca aagtctgggc catcgcctgc ttcgcacccc   1440

aaaaacagtg tcgagaagag gtgctcaaga acttcacaga ccagctgcgg aagatttcca   1500

aggatgcggg gatgcctatc cagggtcaac cttgtttctg caaatatgca cagggggcag   1560

acagcgtgga gcctatgttc cggcatctca agaacaccta ctcagggctg cagctcatta   1620

ttgtcatcct gccagggaag acgccggtgt atgctgaggt gaaacgtgtc ggagatacac   1680

tcttgggaat ggctacgcag tgtgtgcagg tgaagaacgt ggtcaagacc tcacctcaga   1740

ctctgtccaa cctctgcctc aagatcaatg tcaaacttgg tggcattaac aacatcctag   1800

tcccacacca gcgctctgcc gtttttcaac agccagtgat attcctggga gcagatgtta   1860

cacacccccc agcaggggat gggaaaaaac cttctatcac agcagtggta ggcagtatgg   1920

atgcccaccc cagccgatac tgtgctactg tgcgggtaca gcgaccacgg caagagatca   1980

ttgaagactt gtcctacatg gtgcgtgagc tcctcatcca attctacaag tccacccgtt   2040

tcaagcctac ccgcatcatc ttctaccgag atggggtgcc tgaaggccag ctaccccaga   2100

tactccacta tgagctactg gccattcgtg atgcctgcat caaactggaa aaggactacc   2160

agcctgggat cacttatatt gtggtgcaga aacgccatca cacccgcctt ttctgtgctg   2220

acaagaatga gcgaattggg aagagtggta acatcccagc tgggaccaca gtggacacca   2280

acatcaccca cccatttgag tttgacttct atctgtgcag ccacgcaggc atccagggca   2340

ccagccgacc atcccattac tatgttcttt gggatgacaa ccgtttcaca gcagatgagc   2400

tccagatcct gacgtaccag ctgtgccaca cttacgtacg atgcacacgc tctgtctcta   2460

tcccagcacc tgcctactat gcccgcctgg tggctttccg ggcacgatac cacctggtgg   2520

acaaggagca tgacagtgga gaggggagcc acatatcggg gcagagcaat gggcgggacc   2580

cccaggccct ggccaaagcc gtgcaggttc accaggatac tctgcgcacc atgtacttcg   2640

cttgaaggca gaacgctgtt acctcactgg atagaagaaa gctttccaag ccccaggagc   2700

tgtgccaccc aaatccagag gaagcaagga ggagggaggt ggggtaggga ggagtgtagg   2760

atgccttgtt tccttctata gaggtggtgt aagagtgggg aacagggcca gcaagacaga   2820

ccaccagcca gaaatctctg atatcaacct catgtccccc acccctcacc ccatcttgtc   2880

acatctggcc ctgaccccac tggaccaaaa ggggcagcac tggtgcccac catacacaca   2940

ggtgtctcat gtgactcaca gtgctaaaga ctcatgcttg acagcttggt aaggtcaact   3000

ctgtagccct gcagacaaaa gctggttagg tttgggtttg atactttaga tgggaaagtg   3060

aggggcttga gaaagtgggt gggaggaggg aaggattttt taggagcctt aatcagaaaa   3120

ggactagatt tgtttaagaa gaaaaatgaa accagaccca gatcaatatt ttaggatact   3180

agatgtttta atgggttcag aatccagttt gtaggaagat tttttaatgg ttttggttgc   3240

tcctccccca gctgccaccc cccaccttac ccttattcct ctctgtccac attttctgcc   3300

ccaccttact tctcctccct gacagacatc cagcccctag taatacttaa ggcactatgg   3360

cacttagctt tgaagtgaca cgaccctgtc ttccttccgc ccgctggtgg gtaaccagtg   3420

ccttccctgt aacggtaatg ctgcagaact gcaacctttt gtacctttct ttggggaatg   3480

gggtgggggt gggagaggag gtagatgggg aagaaatacc ccagacccaa caaacctcca   3540

gccagaaagc cagctatttt gcatttgaag gaattgactt cctcattcat tgagcttttt   3600

aaaagatcac aacctcaaga tggttaaaat ccattgacat ttgcactttc aaacatgaca   3660

agtctcggag ctgctgagat gacaggcccc tggcctttcc acttatgcct ccttttctcc   3720

ttattcctcc tacctcccgc cccgcccagg tctggagtta ctttcatagc atttttcact   3780

cttggcttct tttctccctt gatggtcaag tctcttatgt ttcaatattt cttaactggg   3840

gtgtcttata acaaaaaact cttaggtcta aaatgagaaa aaagagagaa aacaaaatgt   3900

tatttttata ccataacttg agtgtattgc caaaatttgg aaatccttcc catgcctgat   3960

gagtttatat cccagaaaca ttgagccatc agaatg                             3996


<210>  5926
<211>  782
<212>  PRT
<213>  Homosapiens

<400>  5926

Met Val Gln His Phe Lys Pro Gln Ile Phe Gly Asp Arg Lys Pro Val 
1               5                   10                  15      


Tyr Asp Gly Lys Lys Asn Ile Tyr Thr Val Thr Ala Leu Pro Ile Gly 
            20                  25                  30          


Asn Glu Arg Val Asp Phe Glu Val Thr Ile Pro Gly Glu Gly Lys Asp 
        35                  40                  45              


Arg Ile Phe Lys Val Ser Ile Lys Trp Leu Ala Ile Val Ser Trp Arg 
    50                  55                  60                  


Met Leu His Glu Ala Leu Val Ser Gly Gln Ile Pro Val Pro Leu Glu 
65                  70                  75                  80  


Ser Val Gln Ala Leu Asp Val Ala Met Arg His Leu Ala Ser Met Arg 
                85                  90                  95      


Tyr Thr Pro Val Gly Arg Ser Phe Phe Ser Pro Pro Glu Gly Tyr Tyr 
            100                 105                 110         


His Pro Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser 
        115                 120                 125             


Val Arg Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala 
    130                 135                 140                 


Thr Ala Phe Tyr Lys Ala Gln Pro Val Ile Glu Phe Met Cys Glu Val 
145                 150                 155                 160 


Leu Asp Ile Arg Asn Ile Asp Glu Gln Pro Lys Pro Leu Thr Asp Ser 
                165                 170                 175     


Gln Arg Val Arg Phe Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Val 
            180                 185                 190         


Thr His Cys Gly Gln Met Lys Arg Lys Tyr Arg Val Cys Asn Val Thr 
        195                 200                 205             


Arg Arg Pro Ala Ser His Gln Thr Phe Pro Leu Gln Leu Glu Ser Gly 
    210                 215                 220                 


Gln Thr Val Glu Cys Thr Val Ala Gln Tyr Phe Lys Gln Lys Tyr Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu 
                245                 250                 255     


Gln Lys His Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly 
            260                 265                 270         


Gln Arg Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile 
        275                 280                 285             


Lys Ala Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg 
    290                 295                 300                 


Leu Met Lys Asn Ala Ser Tyr Asn Leu Asp Pro Tyr Ile Gln Glu Phe 
305                 310                 315                 320 


Gly Ile Lys Val Lys Asp Asp Met Thr Glu Val Thr Gly Arg Val Leu 
                325                 330                 335     


Pro Ala Pro Ile Leu Gln Tyr Gly Gly Arg Asn Arg Ala Ile Ala Thr 
            340                 345                 350         


Pro Asn Gln Gly Val Trp Asp Met Arg Gly Lys Gln Phe Tyr Asn Gly 
        355                 360                 365             


Ile Glu Ile Lys Val Trp Ala Ile Ala Cys Phe Ala Pro Gln Lys Gln 
    370                 375                 380                 


Cys Arg Glu Glu Val Leu Lys Asn Phe Thr Asp Gln Leu Arg Lys Ile 
385                 390                 395                 400 


Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys 
                405                 410                 415     


Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys 
            420                 425                 430         


Asn Thr Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys 
        435                 440                 445             


Thr Pro Val Tyr Ala Glu Val Lys Arg Val Gly Asp Thr Leu Leu Gly 
    450                 455                 460                 


Met Ala Thr Gln Cys Val Gln Val Lys Asn Val Val Lys Thr Ser Pro 
465                 470                 475                 480 


Gln Thr Leu Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly 
                485                 490                 495     


Ile Asn Asn Ile Leu Val Pro His Gln Arg Ser Ala Val Phe Gln Gln 
            500                 505                 510         


Pro Val Ile Phe Leu Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp 
        515                 520                 525             


Gly Lys Lys Pro Ser Ile Thr Ala Val Val Gly Ser Met Asp Ala His 
    530                 535                 540                 


Pro Ser Arg Tyr Cys Ala Thr Val Arg Val Gln Arg Pro Arg Gln Glu 
545                 550                 555                 560 


Ile Ile Glu Asp Leu Ser Tyr Met Val Arg Glu Leu Leu Ile Gln Phe 
                565                 570                 575     


Tyr Lys Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp 
            580                 585                 590         


Gly Val Pro Glu Gly Gln Leu Pro Gln Ile Leu His Tyr Glu Leu Leu 
        595                 600                 605             


Ala Ile Arg Asp Ala Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly 
    610                 615                 620                 


Ile Thr Tyr Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys 
625                 630                 635                 640 


Ala Asp Lys Asn Glu Arg Ile Gly Lys Ser Gly Asn Ile Pro Ala Gly 
                645                 650                 655     


Thr Thr Val Asp Thr Asn Ile Thr His Pro Phe Glu Phe Asp Phe Tyr 
            660                 665                 670         


Leu Cys Ser His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr 
        675                 680                 685             


Tyr Val Leu Trp Asp Asp Asn Arg Phe Thr Ala Asp Glu Leu Gln Ile 
    690                 695                 700                 


Leu Thr Tyr Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val 
705                 710                 715                 720 


Ser Ile Pro Ala Pro Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala 
                725                 730                 735     


Arg Tyr His Leu Val Asp Lys Glu His Asp Ser Gly Glu Gly Ser His 
            740                 745                 750         


Ile Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala 
        755                 760                 765             


Val Gln Val His Gln Asp Thr Leu Arg Thr Met Tyr Phe Ala 
    770                 775                 780         


<210>  5927
<211>  6090
<212>  DNA
<213>  Homosapiens

<400>  5927
tgaggcaagc gcctcaggag tgcgtgaggc ccacgcagaa ctcggggagc cttttatcct     60

gaggacacag gggaagaatt ggaggactat attcagctgc gggcgcttac ctgccccccc    120

tgcagcaggt gttccaggca cctcgccggc ctggcattgg cactgtgggg aaaccaatca    180

agctcctggc caattacttt gaggtggaca tccctaagat cgacgtgtac cactacgagg    240

tggacatcaa gccggataag tgtccccgta gagtcaaccg ggaagtggtg gaatacatgg    300

tccagcattt caagcctcag atctttggtg atcgcaagcc tgtgtatgat ggaaagaaga    360

acatttacac tgtcacagca ctgcccattg gcaacgaacg ggtcgacttt gaggtgacaa    420

tccctgggga agggaaggat cgaatcttta aggtctccat caagtggcta gccattgtga    480

gctggcgaat gctgcatgag gccctggtca gcggccagat ccctgttccc ttggagtctg    540

tgcaagccct ggatgtggcc atgaggcacc tggcatccat gaggtacacc cctgtgggcc    600

gctccttctt ctcaccgcct gagggctact accacccgct ggggggtggg cgcgaggtct    660

ggttcggctt tcaccagtct gtgcgccctg ccatgtggaa gatgatgctc aacattgatg    720

tctcagccac tgccttttat aaggcacagc cagtgattga gttcatgtgt gaggtgctgg    780

acatcaggaa catagatgag cagcccaagc ccctcacgga ctctcagcgc gttcgcttca    840

ccaaggagat caagggcctg aaggtggaag tcacccactg tggacagatg aagaggaagt    900

accgcgtgtg taatgttacc cgtcgccctg ctagccatca gacattcccc ttacagctgg    960

agagtggaca gactgtggag tgcacagtgg cacagtattt caagcagaaa tataaccttc   1020

agctcaagta tccccatctg ccctgcctac aagttggcca ggaacaaaag catacctacc   1080

ttcccctaga ggtctgtaac attgtggctg ggcagcgctg tattaaaaag ctgaccgaca   1140

accagacctc gaccatgata aaggccacag ctagatccgc tccagacaga caggaggaga   1200

tcagtcgcct gatgaagaat gccagctaca acttagatcc ctacatccag gaatttggga   1260

tcaaagtgaa ggatgacatg acggaggtga cagggcgagt gctgccggcg cccatcttgc   1320

agtacggcgg ccggaaccgg gccattgcca cacccaatca gggtgtctgg gacatgcggg   1380

ggaaacagtt ctacaatggg attgagatca aagtctgggc catcgcctgc ttcgcacccc   1440

aaaaacagtg tcgagaagag gtgctcaaga acttcacaga ccagctgcgg aagatttcca   1500

aggatgcggg gatgcctatc cagggtcaac cttgtttctg caaatatgca cagggggcag   1560

acagcgtgga gcctatgttc cggcatctca agaacaccta ctcagggctg cagctcatta   1620

ttgtcatcct gccagggaag acgccggtgt atgctgaggt gaaacgtgtc ggagatacac   1680

tcttgggaat ggctacgcag tgtgtgcagg tgaagaacgt ggtcaagacc tcacctcaga   1740

ctctgtccaa cctctgcctc aagatcaatg tcaaacttgg tggcattaac aacatcctag   1800

tcccacacca gcgctctgcc gtttttcaac agccagtgat attcctggga gcagatgtta   1860

cacacccccc agcaggggat gggaaaaaac cttctatcac agcagtggta ggcagtatgg   1920

atgcccaccc cagccgatac tgtgctactg tgcgggtaca gcgaccacgg caagagatca   1980

ttgaagactt gtcctacatg gtgcgtgagc tcctcatcca attctacaag tccacccgtt   2040

tcaagcctac ccgcatcatc ttctaccgag atggggtgcc tgaaggccag ctaccccaga   2100

tactccacta tgagctactg gccattcgtg atgcctgcat caaactggaa aaggactacc   2160

agcctgggat cacttatatt gtggtgcaga aacgccatca cacccgcctt ttctgtgctg   2220

acaagaatga gcgaattggg aagagtggta acatcccagc tgggaccaca gtggacacca   2280

acatcaccca cccatttgag tttgacttct atctgtgcag ccacgcaggc atccagggca   2340

ccagccgacc atcccattac tatgttcttt gggatgacaa ccgtttcaca gcagatgagc   2400

tccagatcct gacgtaccag ctgtgccaca cttacgtacg atgcacacgc tctgtctcta   2460

tcccagcacc tgcctactat gcccgcctgg tggctttccg ggcacgatac cacctggtgg   2520

acaaggagca tgacagtgga gaggggagcc acatatcggg gcagagcaat gggcgggacc   2580

cccaggccct ggccaaagcc gtgcaggttc accaggatac tctgcgcacc atgtacttcg   2640

cttgaaggca gaacgctgtt acctcactgg atagaagaaa gctttccaag ccccaggagc   2700

tgtgccaccc aaatccagag gaagcaagga ggagggaggt ggggtaggga ggagtgtagg   2760

atgccttgtt tccttctata gaggtggtgt aagagtgggg aacagggcca gcaagacaga   2820

ccaccagcca gaaatctctg atatcaacct catgtccccc acccctcacc ccatcttgtc   2880

acatctggcc ctgaccccac tggaccaaaa ggggcagcac tggtgcccac catacacaca   2940

ggtgtctcat gtgactcaca gtgctaaaga ctcatgcttg acagcttggt aaggtcaact   3000

ctgtagccct gcagacaaaa gctggttagg tttgggtttg atactttaga tgggaaagtg   3060

aggggcttga gaaagtgggt gggaggaggg aaggattttt taggagcctt aatcagaaaa   3120

ggactagatt tgtttaagaa gaaaaatgaa accagaccca gatcaatatt ttaggatact   3180

agatgtttta atgggttcag aatccagttt gtaggaagat tttttaatgg ttttggttgc   3240

tcctccccca gctgccaccc cccaccttac ccttattcct ctctgtccac attttctgcc   3300

ccaccttact tctcctccct gacagacatc cagcccctag taatacttaa ggcactatgg   3360

cacttagctt tgaagtgaca cgaccctgtc ttccttccgc ccgctggtgg gtaaccagtg   3420

ccttccctgt aacggtaatg ctgcagaact gcaacctttt gtacctttct ttggggaatg   3480

gggtgggggt gggagaggag gtagatgggg aagaaatacc ccagacccaa caaacctcca   3540

gccagaaagc cagctatttt gcatttgaag gaattgactt cctcattcat tgagcttttt   3600

aaaagatcac aacctcaaga tggttaaaat ccattgacat ttgcactttc aaacatgaca   3660

agtctcggag ctgctgagat gacaggcccc tggcctttcc acttatgcct ccttttctcc   3720

ttattcctcc tacctcccgc cccgcccagg tctggagtta ctttcatagc atttttcact   3780

cttggcttct tttctccctt gatggtcaag tctcttatgt ttcaatattt cttaactggg   3840

gtgtcttata acaaaaaact cttaggtcta aaatgagaaa aaagagagaa aacaaaatgt   3900

tatttttata ccataacttg agtgtattgc caaaatttgg aaatccttcc catgcctgat   3960

gagtttatat cccagaaaca ttgagccatc agaatgaact gtgtacctga tttgttctct   4020

gacctggcta ggtagggagg gggtggttat cgccccaaga tggggtccag gctccatcct   4080

tcctctgtgc agataatacc tttttcttgc tatagcctcc ctcctctgca ctgtcctgca   4140

ctctttcttg caagtgcatc tttttccttc ccctggactg tcctctgacc ctttggctca   4200

tcctagattg cagtgtgtcc tgtggacagg ctggggaatt ttgctgctcc ctattgcttc   4260

tgtttacaaa aatgaatttt tcctggtttc ccactagggc atgtgggtgg gtggcatgga   4320

cttttttttt tttttttttt tgtcttgaga catggggttt ggctgtcttg caggactgga   4380

gaaggtggtg gttctagctt ggtctctgtt ggccttgaag caagcatccc ccctgccctt   4440

tttccttgac tgttcatttt tttcctgccc cactgcttgg gatggggagt tgcaacttca   4500

gtgtggaatt tcctctttga ggagcctggg cttggatcta tcctgatctg gtgatgaagc   4560

catgattact ttagacctag cccaggcttg gaggccagct ggaggaagaa gggtctaaat   4620

cctggcctgt agagttagaa ctaccatttc ctccccttag ctgcccttgt atgacccgga   4680

tttgctatgc aaaacaatct atcccaggtt ctgttctggt tggctacatt gttcagcaac   4740

tcacaaaacg tagcacaaac attcattatg gagaaagcat caggactgtt gagtaactcc   4800

tcctttactt ttttcctgct ggctacagca tggggtgccc tataggcaca agcccagctg   4860

aagaacagaa tggagggctc tgggaggagg cagctcactg gagagcctac attccttaca   4920

caagtgccta aagagagtga tgctaacact ccatctgccc tgtccattgc cttcatatac   4980

agtctacttc gtgttctgtc accctttggg gaggggagtt ctcctgggac agtgggctct   5040

gcatgttctc cacttggata cattttgggg ctaggatcag ggcactattc ctggagggtc   5100

cagtcattca ccagcatttg caaatgtcca tagggagcag gtggcagcct ctactcccag   5160

caacaagttt gtgttctctc cttttctctc tttgcctcac tctctccagt tggttttcag   5220

ctggggcttg aaatgcattt ttagcccttt gacgtggctt atgccattca agaaataaaa   5280

agcaagagaa tcagctttgg gcaatgacaa gaaatgagtt cttactctga tttttttgta   5340

aaaagataat ttttgagact tgaaaaatac cccgaccttg agattattcc tgtttgaaag   5400

gtggtgcatg cagatggaga agtggtgttg gcagcaagct ttggctcatg tggatttggt   5460

ttaagtggtg cttcttaccc aagcttcaag gaagtgcttg ggggaccccc agcctcatcc   5520

tcttagttgg gtctcttgtt ccctttgtac cactgttttg ccttcctttt cctcttctct   5580

ctttgcctgg cttcctttcc cttttcttct attcactctg cttgcttgct ggccggcctg   5640

cctgcctgcc tgcctgcctg cctgcctgtc tgcctatgtg atgatgaaat ctctgcatgg   5700

ctgcaatgat cccactgtta gctggcaggg tcaggcttag ctccttgact gcagaagacc   5760

aagaacctgt tccccaagcc cagagatgtc cacctgggct ggactgccct caagcttata   5820

ctagagaaga gcaactgacc tgcccaactt gtgtgaagtc aggagggttt ctggcatttt   5880

ccacacctgt ccactccttg gagctggttt ctctcattgc tttttctaaa tctggttctt   5940

tttctcttta cctggggcct ggcttttctg agattgtctt agggttgagc tatttgggta   6000

tcctgggttt gagtgttagg ggatggacat aaaggaaaaa gagtgatgag aagagaatgg   6060

agagaatttg aataaaaggt gggaaaggag                                    6090


<210>  5928
<211>  782
<212>  PRT
<213>  Homosapiens

<400>  5928

Met Val Gln His Phe Lys Pro Gln Ile Phe Gly Asp Arg Lys Pro Val 
1               5                   10                  15      


Tyr Asp Gly Lys Lys Asn Ile Tyr Thr Val Thr Ala Leu Pro Ile Gly 
            20                  25                  30          


Asn Glu Arg Val Asp Phe Glu Val Thr Ile Pro Gly Glu Gly Lys Asp 
        35                  40                  45              


Arg Ile Phe Lys Val Ser Ile Lys Trp Leu Ala Ile Val Ser Trp Arg 
    50                  55                  60                  


Met Leu His Glu Ala Leu Val Ser Gly Gln Ile Pro Val Pro Leu Glu 
65                  70                  75                  80  


Ser Val Gln Ala Leu Asp Val Ala Met Arg His Leu Ala Ser Met Arg 
                85                  90                  95      


Tyr Thr Pro Val Gly Arg Ser Phe Phe Ser Pro Pro Glu Gly Tyr Tyr 
            100                 105                 110         


His Pro Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser 
        115                 120                 125             


Val Arg Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala 
    130                 135                 140                 


Thr Ala Phe Tyr Lys Ala Gln Pro Val Ile Glu Phe Met Cys Glu Val 
145                 150                 155                 160 


Leu Asp Ile Arg Asn Ile Asp Glu Gln Pro Lys Pro Leu Thr Asp Ser 
                165                 170                 175     


Gln Arg Val Arg Phe Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Val 
            180                 185                 190         


Thr His Cys Gly Gln Met Lys Arg Lys Tyr Arg Val Cys Asn Val Thr 
        195                 200                 205             


Arg Arg Pro Ala Ser His Gln Thr Phe Pro Leu Gln Leu Glu Ser Gly 
    210                 215                 220                 


Gln Thr Val Glu Cys Thr Val Ala Gln Tyr Phe Lys Gln Lys Tyr Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu 
                245                 250                 255     


Gln Lys His Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly 
            260                 265                 270         


Gln Arg Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile 
        275                 280                 285             


Lys Ala Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg 
    290                 295                 300                 


Leu Met Lys Asn Ala Ser Tyr Asn Leu Asp Pro Tyr Ile Gln Glu Phe 
305                 310                 315                 320 


Gly Ile Lys Val Lys Asp Asp Met Thr Glu Val Thr Gly Arg Val Leu 
                325                 330                 335     


Pro Ala Pro Ile Leu Gln Tyr Gly Gly Arg Asn Arg Ala Ile Ala Thr 
            340                 345                 350         


Pro Asn Gln Gly Val Trp Asp Met Arg Gly Lys Gln Phe Tyr Asn Gly 
        355                 360                 365             


Ile Glu Ile Lys Val Trp Ala Ile Ala Cys Phe Ala Pro Gln Lys Gln 
    370                 375                 380                 


Cys Arg Glu Glu Val Leu Lys Asn Phe Thr Asp Gln Leu Arg Lys Ile 
385                 390                 395                 400 


Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys 
                405                 410                 415     


Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys 
            420                 425                 430         


Asn Thr Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys 
        435                 440                 445             


Thr Pro Val Tyr Ala Glu Val Lys Arg Val Gly Asp Thr Leu Leu Gly 
    450                 455                 460                 


Met Ala Thr Gln Cys Val Gln Val Lys Asn Val Val Lys Thr Ser Pro 
465                 470                 475                 480 


Gln Thr Leu Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly 
                485                 490                 495     


Ile Asn Asn Ile Leu Val Pro His Gln Arg Ser Ala Val Phe Gln Gln 
            500                 505                 510         


Pro Val Ile Phe Leu Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp 
        515                 520                 525             


Gly Lys Lys Pro Ser Ile Thr Ala Val Val Gly Ser Met Asp Ala His 
    530                 535                 540                 


Pro Ser Arg Tyr Cys Ala Thr Val Arg Val Gln Arg Pro Arg Gln Glu 
545                 550                 555                 560 


Ile Ile Glu Asp Leu Ser Tyr Met Val Arg Glu Leu Leu Ile Gln Phe 
                565                 570                 575     


Tyr Lys Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp 
            580                 585                 590         


Gly Val Pro Glu Gly Gln Leu Pro Gln Ile Leu His Tyr Glu Leu Leu 
        595                 600                 605             


Ala Ile Arg Asp Ala Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly 
    610                 615                 620                 


Ile Thr Tyr Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys 
625                 630                 635                 640 


Ala Asp Lys Asn Glu Arg Ile Gly Lys Ser Gly Asn Ile Pro Ala Gly 
                645                 650                 655     


Thr Thr Val Asp Thr Asn Ile Thr His Pro Phe Glu Phe Asp Phe Tyr 
            660                 665                 670         


Leu Cys Ser His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr 
        675                 680                 685             


Tyr Val Leu Trp Asp Asp Asn Arg Phe Thr Ala Asp Glu Leu Gln Ile 
    690                 695                 700                 


Leu Thr Tyr Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val 
705                 710                 715                 720 


Ser Ile Pro Ala Pro Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala 
                725                 730                 735     


Arg Tyr His Leu Val Asp Lys Glu His Asp Ser Gly Glu Gly Ser His 
            740                 745                 750         


Ile Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala 
        755                 760                 765             


Val Gln Val His Gln Asp Thr Leu Arg Thr Met Tyr Phe Ala 
    770                 775                 780         


<210>  5929
<211>  7334
<212>  DNA
<213>  Homosapiens

<400>  5929
tgaggcaagc gcctcaggag tgcgtgaggc ccacgcagaa ctcggggagc cttttatcct     60

gaggacacag gggaagaatt ggaggactat attcagctgc gggcgcttac ctgccccccc    120

tgcagcaggt gttccaggca cctcgccggc ctggcattgg cactgtgggg aaaccaatca    180

agctcctggc caattacttt gaggtggaca tccctaagat cgacgtgtac cactacgagg    240

tggacatcaa gccggataag tgtccccgta gagtcaaccg ggaagtggtg gaatacatgg    300

tccagcattt caagcctcag atctttggtg atcgcaagcc tgtgtatgat ggaaagaaga    360

acatttacac tgtcacagca ctgcccattg gcaacgaacg ggtcgacttt gaggtgacaa    420

tccctgggga agggaaggat cgaatcttta aggtctccat caagtggcta gccattgtga    480

gctggcgaat gctgcatgag gccctggtca gcggccagat ccctgttccc ttggagtctg    540

tgcaagccct ggatgtggcc atgaggcacc tggcatccat gaggtacacc cctgtgggcc    600

gctccttctt ctcaccgcct gagggctact accacccgct ggggggtggg cgcgaggtct    660

ggttcggctt tcaccagtct gtgcgccctg ccatgtggaa gatgatgctc aacattgatg    720

tctcagccac tgccttttat aaggcacagc cagtgattga gttcatgtgt gaggtgctgg    780

acatcaggaa catagatgag cagcccaagc ccctcacgga ctctcagcgc gttcgcttca    840

ccaaggagat caagggcctg aaggtggaag tcacccactg tggacagatg aagaggaagt    900

accgcgtgtg taatgttacc cgtcgccctg ctagccatca gacattcccc ttacagctgg    960

agagtggaca gactgtggag tgcacagtgg cacagtattt caagcagaaa tataaccttc   1020

agctcaagta tccccatctg ccctgcctac aagttggcca ggaacaaaag catacctacc   1080

ttcccctaga ggtctgtaac attgtggctg ggcagcgctg tattaaaaag ctgaccgaca   1140

accagacctc gaccatgata aaggccacag ctagatccgc tccagacaga caggaggaga   1200

tcagtcgcct gatgaagaat gccagctaca acttagatcc ctacatccag gaatttggga   1260

tcaaagtgaa ggatgacatg acggaggtga cagggcgagt gctgccggcg cccatcttgc   1320

agtacggcgg ccggaaccgg gccattgcca cacccaatca gggtgtctgg gacatgcggg   1380

ggaaacagtt ctacaatggg attgagatca aagtctgggc catcgcctgc ttcgcacccc   1440

aaaaacagtg tcgagaagag gtgctcaaga acttcacaga ccagctgcgg aagatttcca   1500

aggatgcggg gatgcctatc cagggtcaac cttgtttctg caaatatgca cagggggcag   1560

acagcgtgga gcctatgttc cggcatctca agaacaccta ctcagggctg cagctcatta   1620

ttgtcatcct gccagggaag acgccggtgt atgctgaggt gaaacgtgtc ggagatacac   1680

tcttgggaat ggctacgcag tgtgtgcagg tgaagaacgt ggtcaagacc tcacctcaga   1740

ctctgtccaa cctctgcctc aagatcaatg tcaaacttgg tggcattaac aacatcctag   1800

tcccacacca gcgctctgcc gtttttcaac agccagtgat attcctggga gcagatgtta   1860

cacacccccc agcaggggat gggaaaaaac cttctatcac agcagtggta ggcagtatgg   1920

atgcccaccc cagccgatac tgtgctactg tgcgggtaca gcgaccacgg caagagatca   1980

ttgaagactt gtcctacatg gtgcgtgagc tcctcatcca attctacaag tccacccgtt   2040

tcaagcctac ccgcatcatc ttctaccgag atggggtgcc tgaaggccag ctaccccaga   2100

tactccacta tgagctactg gccattcgtg atgcctgcat caaactggaa aaggactacc   2160

agcctgggat cacttatatt gtggtgcaga aacgccatca cacccgcctt ttctgtgctg   2220

acaagaatga gcgaattggg aagagtggta acatcccagc tgggaccaca gtggacacca   2280

acatcaccca cccatttgag tttgacttct atctgtgcag ccacgcaggc atccagggca   2340

ccagccgacc atcccattac tatgttcttt gggatgacaa ccgtttcaca gcagatgagc   2400

tccagatcct gacgtaccag ctgtgccaca cttacgtacg atgcacacgc tctgtctcta   2460

tcccagcacc tgcctactat gcccgcctgg tggctttccg ggcacgatac cacctggtgg   2520

acaaggagca tgacagtgga gaggggagcc acatatcggg gcagagcaat gggcgggacc   2580

cccaggccct ggccaaagcc gtgcaggttc accaggatac tctgcgcacc atgtacttcg   2640

cttgaaggca gaacgctgtt acctcactgg atagaagaaa gctttccaag ccccaggagc   2700

tgtgccaccc aaatccagag gaagcaagga ggagggaggt ggggtaggga ggagtgtagg   2760

atgccttgtt tccttctata gaggtggtgt aagagtgggg aacagggcca gcaagacaga   2820

ccaccagcca gaaatctctg atatcaacct catgtccccc acccctcacc ccatcttgtc   2880

acatctggcc ctgaccccac tggaccaaaa ggggcagcac tggtgcccac catacacaca   2940

ggtgtctcat gtgactcaca gtgctaaaga ctcatgcttg acagcttggt aaggtcaact   3000

ctgtagccct gcagacaaaa gctggttagg tttgggtttg atactttaga tgggaaagtg   3060

aggggcttga gaaagtgggt gggaggaggg aaggattttt taggagcctt aatcagaaaa   3120

ggactagatt tgtttaagaa gaaaaatgaa accagaccca gatcaatatt ttaggatact   3180

agatgtttta atgggttcag aatccagttt gtaggaagat tttttaatgg ttttggttgc   3240

tcctccccca gctgccaccc cccaccttac ccttattcct ctctgtccac attttctgcc   3300

ccaccttact tctcctccct gacagacatc cagcccctag taatacttaa ggcactatgg   3360

cacttagctt tgaagtgaca cgaccctgtc ttccttccgc ccgctggtgg gtaaccagtg   3420

ccttccctgt aacggtaatg ctgcagaact gcaacctttt gtacctttct ttggggaatg   3480

gggtgggggt gggagaggag gtagatgggg aagaaatacc ccagacccaa caaacctcca   3540

gccagaaagc cagctatttt gcatttgaag gaattgactt cctcattcat tgagcttttt   3600

aaaagatcac aacctcaaga tggttaaaat ccattgacat ttgcactttc aaacatgaca   3660

agtctcggag ctgctgagat gacaggcccc tggcctttcc acttatgcct ccttttctcc   3720

ttattcctcc tacctcccgc cccgcccagg tctggagtta ctttcatagc atttttcact   3780

cttggcttct tttctccctt gatggtcaag tctcttatgt ttcaatattt cttaactggg   3840

gtgtcttata acaaaaaact cttaggtcta aaatgagaaa aaagagagaa aacaaaatgt   3900

tatttttata ccataacttg agtgtattgc caaaatttgg aaatccttcc catgcctgat   3960

gagtttatat cccagaaaca ttgagccatc agaatgaact gtgtacctga tttgttctct   4020

gacctggcta ggtagggagg gggtggttat cgccccaaga tggggtccag gctccatcct   4080

tcctctgtgc agataatacc tttttcttgc tatagcctcc ctcctctgca ctgtcctgca   4140

ctctttcttg caagtgcatc tttttccttc ccctggactg tcctctgacc ctttggctca   4200

tcctagattg cagtgtgtcc tgtggacagg ctggggaatt ttgctgctcc ctattgcttc   4260

tgtttacaaa aatgaatttt tcctggtttc ccactagggc atgtgggtgg gtggcatgga   4320

cttttttttt tttttttttt tgtcttgaga catggggttt ggctgtcttg caggactgga   4380

gaaggtggtg gttctagctt ggtctctgtt ggccttgaag caagcatccc ccctgccctt   4440

tttccttgac tgttcatttt tttcctgccc cactgcttgg gatggggagt tgcaacttca   4500

gtgtggaatt tcctctttga ggagcctggg cttggatcta tcctgatctg gtgatgaagc   4560

catgattact ttagacctag cccaggcttg gaggccagct ggaggaagaa gggtctaaat   4620

cctggcctgt agagttagaa ctaccatttc ctccccttag ctgcccttgt atgacccgga   4680

tttgctatgc aaaacaatct atcccaggtt ctgttctggt tggctacatt gttcagcaac   4740

tcacaaaacg tagcacaaac attcattatg gagaaagcat caggactgtt gagtaactcc   4800

tcctttactt ttttcctgct ggctacagca tggggtgccc tataggcaca agcccagctg   4860

aagaacagaa tggagggctc tgggaggagg cagctcactg gagagcctac attccttaca   4920

caagtgccta aagagagtga tgctaacact ccatctgccc tgtccattgc cttcatatac   4980

agtctacttc gtgttctgtc accctttggg gaggggagtt ctcctgggac agtgggctct   5040

gcatgttctc cacttggata cattttgggg ctaggatcag ggcactattc ctggagggtc   5100

cagtcattca ccagcatttg caaatgtcca tagggagcag gtggcagcct ctactcccag   5160

caacaagttt gtgttctctc cttttctctc tttgcctcac tctctccagt tggttttcag   5220

ctggggcttg aaatgcattt ttagcccttt gacgtggctt atgccattca agaaataaaa   5280

agcaagagaa tcagctttgg gcaatgacaa gaaatgagtt cttactctga tttttttgta   5340

aaaagataat ttttgagact tgaaaaatac cccgaccttg agattattcc tgtttgaaag   5400

gtggtgcatg cagatggaga agtggtgttg gcagcaagct ttggctcatg tggatttggt   5460

ttaagtggtg cttcttaccc aagcttcaag gaagtgcttg ggggaccccc agcctcatcc   5520

tcttagttgg gtctcttgtt ccctttgtac cactgttttg ccttcctttt cctcttctct   5580

ctttgcctgg cttcctttcc cttttcttct attcactctg cttgcttgct ggccggcctg   5640

cctgcctgcc tgcctgcctg cctgcctgtc tgcctatgtg atgatgaaat ctctgcatgg   5700

ctgcaatgat cccactgtta gctggcaggg tcaggcttag ctccttgact gcagaagacc   5760

aagaacctgt tccccaagcc cagagatgtc cacctgggct ggactgccct caagcttata   5820

ctagagaaga gcaactgacc tgcccaactt gtgtgaagtc aggagggttt ctggcatttt   5880

ccacacctgt ccactccttg gagctggttt ctctcattgc tttttctaaa tctggttctt   5940

tttctcttta cctggggcct ggcttttctg agattgtctt agggttgagc tatttgggta   6000

tcctgggttt gagtgttagg ggatggacat aaaggaaaaa gagtgatgag aagagaatgg   6060

agagaatttg aataaaaggt gggaaaggag agcactgttc tttgattgtt tatccagtcc   6120

aacctgatcc attagggatc gaggtgctac actggcctcc agggataagc ctggggctac   6180

tgttgctggg aacttaggct taacataaag ccgaagaagg tacctagaaa tttgaaactt   6240

ccctaaaaag ctcctaatgc ccacctgcta gatagcttct ctgtggcctc ctatttagct   6300

aagcagcagt gtttttggat actttttttt tctgtttgtg aataaggcca gcactcaaga   6360

tgggcagcca agggtgcact gactattagc tggcccatag gatatctgta aggctggtgg   6420

gacagttttg gacctggaat catgtgtaac taacaaggtt ggacgtttct tccccatcag   6480

ggtagaaaaa tcatctcaaa ctagccaaaa ggcagttttg gaaactacat tgggggacgt   6540

tatttttatt tatatatggg gcctaggcca atccaggatg gtagctggaa taccttcctt   6600

cttaaaatct gatcatggca gggatatgca gggcactttt tactatttgg ccttctaagc   6660

agattgggaa ggaggtattt tctggttttc gctttcctcc gacttaatag gacttgcctt   6720

ctccctgggc agggagagag gctgggttgg tgctctccct tactctactc atactgactt   6780

agagcctctg gctgctgttt gggcatccaa gaaagggagg ggaaggaatg agctaaaaac   6840

aaaacagaat gaggtgggaa agggagattt tcttctttac agaggaaaat aggaaaccct   6900

ccaagaattg tgcaagtaaa gacatttgtt gaatgcactg agtcccttgg tgtagtagca   6960

ataaggaaaa atgaaattac tttcctgtgc acacagtcca gcctaattgg tatgtgatgt   7020

tgcacttagc agccatgtgg tgggcatgtg tgactactct ggttttcact ttagtttcta   7080

aactttttat ccctctcaag tccagcatgg atggggaaat gtctctggat ccccacagct   7140

gtgtacttgt ttgcatttgt ttccctttga gatttgtgtt tgtgtcctgc tttgagctgt   7200

accttgtcca gtccattgtg aaattatccc agcagctgta atgtacagtt ccttctgaag   7260

caagcaacat cagcagcagc agcagcagca gcacaattct gtgttttata aagacaacag   7320

tggcttctat ttct                                                     7334


<210>  5930
<211>  782
<212>  PRT
<213>  Homosapiens

<400>  5930

Met Val Gln His Phe Lys Pro Gln Ile Phe Gly Asp Arg Lys Pro Val 
1               5                   10                  15      


Tyr Asp Gly Lys Lys Asn Ile Tyr Thr Val Thr Ala Leu Pro Ile Gly 
            20                  25                  30          


Asn Glu Arg Val Asp Phe Glu Val Thr Ile Pro Gly Glu Gly Lys Asp 
        35                  40                  45              


Arg Ile Phe Lys Val Ser Ile Lys Trp Leu Ala Ile Val Ser Trp Arg 
    50                  55                  60                  


Met Leu His Glu Ala Leu Val Ser Gly Gln Ile Pro Val Pro Leu Glu 
65                  70                  75                  80  


Ser Val Gln Ala Leu Asp Val Ala Met Arg His Leu Ala Ser Met Arg 
                85                  90                  95      


Tyr Thr Pro Val Gly Arg Ser Phe Phe Ser Pro Pro Glu Gly Tyr Tyr 
            100                 105                 110         


His Pro Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser 
        115                 120                 125             


Val Arg Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala 
    130                 135                 140                 


Thr Ala Phe Tyr Lys Ala Gln Pro Val Ile Glu Phe Met Cys Glu Val 
145                 150                 155                 160 


Leu Asp Ile Arg Asn Ile Asp Glu Gln Pro Lys Pro Leu Thr Asp Ser 
                165                 170                 175     


Gln Arg Val Arg Phe Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Val 
            180                 185                 190         


Thr His Cys Gly Gln Met Lys Arg Lys Tyr Arg Val Cys Asn Val Thr 
        195                 200                 205             


Arg Arg Pro Ala Ser His Gln Thr Phe Pro Leu Gln Leu Glu Ser Gly 
    210                 215                 220                 


Gln Thr Val Glu Cys Thr Val Ala Gln Tyr Phe Lys Gln Lys Tyr Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu 
                245                 250                 255     


Gln Lys His Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly 
            260                 265                 270         


Gln Arg Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile 
        275                 280                 285             


Lys Ala Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg 
    290                 295                 300                 


Leu Met Lys Asn Ala Ser Tyr Asn Leu Asp Pro Tyr Ile Gln Glu Phe 
305                 310                 315                 320 


Gly Ile Lys Val Lys Asp Asp Met Thr Glu Val Thr Gly Arg Val Leu 
                325                 330                 335     


Pro Ala Pro Ile Leu Gln Tyr Gly Gly Arg Asn Arg Ala Ile Ala Thr 
            340                 345                 350         


Pro Asn Gln Gly Val Trp Asp Met Arg Gly Lys Gln Phe Tyr Asn Gly 
        355                 360                 365             


Ile Glu Ile Lys Val Trp Ala Ile Ala Cys Phe Ala Pro Gln Lys Gln 
    370                 375                 380                 


Cys Arg Glu Glu Val Leu Lys Asn Phe Thr Asp Gln Leu Arg Lys Ile 
385                 390                 395                 400 


Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys 
                405                 410                 415     


Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys 
            420                 425                 430         


Asn Thr Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys 
        435                 440                 445             


Thr Pro Val Tyr Ala Glu Val Lys Arg Val Gly Asp Thr Leu Leu Gly 
    450                 455                 460                 


Met Ala Thr Gln Cys Val Gln Val Lys Asn Val Val Lys Thr Ser Pro 
465                 470                 475                 480 


Gln Thr Leu Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly 
                485                 490                 495     


Ile Asn Asn Ile Leu Val Pro His Gln Arg Ser Ala Val Phe Gln Gln 
            500                 505                 510         


Pro Val Ile Phe Leu Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp 
        515                 520                 525             


Gly Lys Lys Pro Ser Ile Thr Ala Val Val Gly Ser Met Asp Ala His 
    530                 535                 540                 


Pro Ser Arg Tyr Cys Ala Thr Val Arg Val Gln Arg Pro Arg Gln Glu 
545                 550                 555                 560 


Ile Ile Glu Asp Leu Ser Tyr Met Val Arg Glu Leu Leu Ile Gln Phe 
                565                 570                 575     


Tyr Lys Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp 
            580                 585                 590         


Gly Val Pro Glu Gly Gln Leu Pro Gln Ile Leu His Tyr Glu Leu Leu 
        595                 600                 605             


Ala Ile Arg Asp Ala Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly 
    610                 615                 620                 


Ile Thr Tyr Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys 
625                 630                 635                 640 


Ala Asp Lys Asn Glu Arg Ile Gly Lys Ser Gly Asn Ile Pro Ala Gly 
                645                 650                 655     


Thr Thr Val Asp Thr Asn Ile Thr His Pro Phe Glu Phe Asp Phe Tyr 
            660                 665                 670         


Leu Cys Ser His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr 
        675                 680                 685             


Tyr Val Leu Trp Asp Asp Asn Arg Phe Thr Ala Asp Glu Leu Gln Ile 
    690                 695                 700                 


Leu Thr Tyr Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val 
705                 710                 715                 720 


Ser Ile Pro Ala Pro Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala 
                725                 730                 735     


Arg Tyr His Leu Val Asp Lys Glu His Asp Ser Gly Glu Gly Ser His 
            740                 745                 750         


Ile Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala 
        755                 760                 765             


Val Gln Val His Gln Asp Thr Leu Arg Thr Met Tyr Phe Ala 
    770                 775                 780         


<210>  5931
<211>  7840
<212>  DNA
<213>  Homosapiens

<400>  5931
tgaggcaagc gcctcaggag tgcgtgaggc ccacgcagaa ctcggggagc cttttatcct     60

gaggacacag gggaagaatt ggaggactat attcagctgc gggcgcttac ctgccccccc    120

tgcagcaggt gttccaggca cctcgccggc ctggcattgg cactgtgggg aaaccaatca    180

agctcctggc caattacttt gaggtggaca tccctaagat cgacgtgtac cactacgagg    240

tggacatcaa gccggataag tgtccccgta gagtcaaccg ggaagtggtg gaatacatgg    300

tccagcattt caagcctcag atctttggtg atcgcaagcc tgtgtatgat ggaaagaaga    360

acatttacac tgtcacagca ctgcccattg gcaacgaacg ggtcgacttt gaggtgacaa    420

tccctgggga agggaaggat cgaatcttta aggtctccat caagtggcta gccattgtga    480

gctggcgaat gctgcatgag gccctggtca gcggccagat ccctgttccc ttggagtctg    540

tgcaagccct ggatgtggcc atgaggcacc tggcatccat gaggtacacc cctgtgggcc    600

gctccttctt ctcaccgcct gagggctact accacccgct ggggggtggg cgcgaggtct    660

ggttcggctt tcaccagtct gtgcgccctg ccatgtggaa gatgatgctc aacattgatg    720

tctcagccac tgccttttat aaggcacagc cagtgattga gttcatgtgt gaggtgctgg    780

acatcaggaa catagatgag cagcccaagc ccctcacgga ctctcagcgc gttcgcttca    840

ccaaggagat caagggcctg aaggtggaag tcacccactg tggacagatg aagaggaagt    900

accgcgtgtg taatgttacc cgtcgccctg ctagccatca gacattcccc ttacagctgg    960

agagtggaca gactgtggag tgcacagtgg cacagtattt caagcagaaa tataaccttc   1020

agctcaagta tccccatctg ccctgcctac aagttggcca ggaacaaaag catacctacc   1080

ttcccctaga ggtctgtaac attgtggctg ggcagcgctg tattaaaaag ctgaccgaca   1140

accagacctc gaccatgata aaggccacag ctagatccgc tccagacaga caggaggaga   1200

tcagtcgcct gatgaagaat gccagctaca acttagatcc ctacatccag gaatttggga   1260

tcaaagtgaa ggatgacatg acggaggtga cagggcgagt gctgccggcg cccatcttgc   1320

agtacggcgg ccggaaccgg gccattgcca cacccaatca gggtgtctgg gacatgcggg   1380

ggaaacagtt ctacaatggg attgagatca aagtctgggc catcgcctgc ttcgcacccc   1440

aaaaacagtg tcgagaagag gtgctcaaga acttcacaga ccagctgcgg aagatttcca   1500

aggatgcggg gatgcctatc cagggtcaac cttgtttctg caaatatgca cagggggcag   1560

acagcgtgga gcctatgttc cggcatctca agaacaccta ctcagggctg cagctcatta   1620

ttgtcatcct gccagggaag acgccggtgt atgctgaggt gaaacgtgtc ggagatacac   1680

tcttgggaat ggctacgcag tgtgtgcagg tgaagaacgt ggtcaagacc tcacctcaga   1740

ctctgtccaa cctctgcctc aagatcaatg tcaaacttgg tggcattaac aacatcctag   1800

tcccacacca gcgctctgcc gtttttcaac agccagtgat attcctggga gcagatgtta   1860

cacacccccc agcaggggat gggaaaaaac cttctatcac agcagtggta ggcagtatgg   1920

atgcccaccc cagccgatac tgtgctactg tgcgggtaca gcgaccacgg caagagatca   1980

ttgaagactt gtcctacatg gtgcgtgagc tcctcatcca attctacaag tccacccgtt   2040

tcaagcctac ccgcatcatc ttctaccgag atggggtgcc tgaaggccag ctaccccaga   2100

tactccacta tgagctactg gccattcgtg atgcctgcat caaactggaa aaggactacc   2160

agcctgggat cacttatatt gtggtgcaga aacgccatca cacccgcctt ttctgtgctg   2220

acaagaatga gcgaattggg aagagtggta acatcccagc tgggaccaca gtggacacca   2280

acatcaccca cccatttgag tttgacttct atctgtgcag ccacgcaggc atccagggca   2340

ccagccgacc atcccattac tatgttcttt gggatgacaa ccgtttcaca gcagatgagc   2400

tccagatcct gacgtaccag ctgtgccaca cttacgtacg atgcacacgc tctgtctcta   2460

tcccagcacc tgcctactat gcccgcctgg tggctttccg ggcacgatac cacctggtgg   2520

acaaggagca tgacagtgga gaggggagcc acatatcggg gcagagcaat gggcgggacc   2580

cccaggccct ggccaaagcc gtgcaggttc accaggatac tctgcgcacc atgtacttcg   2640

cttgaaggca gaacgctgtt acctcactgg atagaagaaa gctttccaag ccccaggagc   2700

tgtgccaccc aaatccagag gaagcaagga ggagggaggt ggggtaggga ggagtgtagg   2760

atgccttgtt tccttctata gaggtggtgt aagagtgggg aacagggcca gcaagacaga   2820

ccaccagcca gaaatctctg atatcaacct catgtccccc acccctcacc ccatcttgtc   2880

acatctggcc ctgaccccac tggaccaaaa ggggcagcac tggtgcccac catacacaca   2940

ggtgtctcat gtgactcaca gtgctaaaga ctcatgcttg acagcttggt aaggtcaact   3000

ctgtagccct gcagacaaaa gctggttagg tttgggtttg atactttaga tgggaaagtg   3060

aggggcttga gaaagtgggt gggaggaggg aaggattttt taggagcctt aatcagaaaa   3120

ggactagatt tgtttaagaa gaaaaatgaa accagaccca gatcaatatt ttaggatact   3180

agatgtttta atgggttcag aatccagttt gtaggaagat tttttaatgg ttttggttgc   3240

tcctccccca gctgccaccc cccaccttac ccttattcct ctctgtccac attttctgcc   3300

ccaccttact tctcctccct gacagacatc cagcccctag taatacttaa ggcactatgg   3360

cacttagctt tgaagtgaca cgaccctgtc ttccttccgc ccgctggtgg gtaaccagtg   3420

ccttccctgt aacggtaatg ctgcagaact gcaacctttt gtacctttct ttggggaatg   3480

gggtgggggt gggagaggag gtagatgggg aagaaatacc ccagacccaa caaacctcca   3540

gccagaaagc cagctatttt gcatttgaag gaattgactt cctcattcat tgagcttttt   3600

aaaagatcac aacctcaaga tggttaaaat ccattgacat ttgcactttc aaacatgaca   3660

agtctcggag ctgctgagat gacaggcccc tggcctttcc acttatgcct ccttttctcc   3720

ttattcctcc tacctcccgc cccgcccagg tctggagtta ctttcatagc atttttcact   3780

cttggcttct tttctccctt gatggtcaag tctcttatgt ttcaatattt cttaactggg   3840

gtgtcttata acaaaaaact cttaggtcta aaatgagaaa aaagagagaa aacaaaatgt   3900

tatttttata ccataacttg agtgtattgc caaaatttgg aaatccttcc catgcctgat   3960

gagtttatat cccagaaaca ttgagccatc agaatgaact gtgtacctga tttgttctct   4020

gacctggcta ggtagggagg gggtggttat cgccccaaga tggggtccag gctccatcct   4080

tcctctgtgc agataatacc tttttcttgc tatagcctcc ctcctctgca ctgtcctgca   4140

ctctttcttg caagtgcatc tttttccttc ccctggactg tcctctgacc ctttggctca   4200

tcctagattg cagtgtgtcc tgtggacagg ctggggaatt ttgctgctcc ctattgcttc   4260

tgtttacaaa aatgaatttt tcctggtttc ccactagggc atgtgggtgg gtggcatgga   4320

cttttttttt tttttttttt tgtcttgaga catggggttt ggctgtcttg caggactgga   4380

gaaggtggtg gttctagctt ggtctctgtt ggccttgaag caagcatccc ccctgccctt   4440

tttccttgac tgttcatttt tttcctgccc cactgcttgg gatggggagt tgcaacttca   4500

gtgtggaatt tcctctttga ggagcctggg cttggatcta tcctgatctg gtgatgaagc   4560

catgattact ttagacctag cccaggcttg gaggccagct ggaggaagaa gggtctaaat   4620

cctggcctgt agagttagaa ctaccatttc ctccccttag ctgcccttgt atgacccgga   4680

tttgctatgc aaaacaatct atcccaggtt ctgttctggt tggctacatt gttcagcaac   4740

tcacaaaacg tagcacaaac attcattatg gagaaagcat caggactgtt gagtaactcc   4800

tcctttactt ttttcctgct ggctacagca tggggtgccc tataggcaca agcccagctg   4860

aagaacagaa tggagggctc tgggaggagg cagctcactg gagagcctac attccttaca   4920

caagtgccta aagagagtga tgctaacact ccatctgccc tgtccattgc cttcatatac   4980

agtctacttc gtgttctgtc accctttggg gaggggagtt ctcctgggac agtgggctct   5040

gcatgttctc cacttggata cattttgggg ctaggatcag ggcactattc ctggagggtc   5100

cagtcattca ccagcatttg caaatgtcca tagggagcag gtggcagcct ctactcccag   5160

caacaagttt gtgttctctc cttttctctc tttgcctcac tctctccagt tggttttcag   5220

ctggggcttg aaatgcattt ttagcccttt gacgtggctt atgccattca agaaataaaa   5280

agcaagagaa tcagctttgg gcaatgacaa gaaatgagtt cttactctga tttttttgta   5340

aaaagataat ttttgagact tgaaaaatac cccgaccttg agattattcc tgtttgaaag   5400

gtggtgcatg cagatggaga agtggtgttg gcagcaagct ttggctcatg tggatttggt   5460

ttaagtggtg cttcttaccc aagcttcaag gaagtgcttg ggggaccccc agcctcatcc   5520

tcttagttgg gtctcttgtt ccctttgtac cactgttttg ccttcctttt cctcttctct   5580

ctttgcctgg cttcctttcc cttttcttct attcactctg cttgcttgct ggccggcctg   5640

cctgcctgcc tgcctgcctg cctgcctgtc tgcctatgtg atgatgaaat ctctgcatgg   5700

ctgcaatgat cccactgtta gctggcaggg tcaggcttag ctccttgact gcagaagacc   5760

aagaacctgt tccccaagcc cagagatgtc cacctgggct ggactgccct caagcttata   5820

ctagagaaga gcaactgacc tgcccaactt gtgtgaagtc aggagggttt ctggcatttt   5880

ccacacctgt ccactccttg gagctggttt ctctcattgc tttttctaaa tctggttctt   5940

tttctcttta cctggggcct ggcttttctg agattgtctt agggttgagc tatttgggta   6000

tcctgggttt gagtgttagg ggatggacat aaaggaaaaa gagtgatgag aagagaatgg   6060

agagaatttg aataaaaggt gggaaaggag agcactgttc tttgattgtt tatccagtcc   6120

aacctgatcc attagggatc gaggtgctac actggcctcc agggataagc ctggggctac   6180

tgttgctggg aacttaggct taacataaag ccgaagaagg tacctagaaa tttgaaactt   6240

ccctaaaaag ctcctaatgc ccacctgcta gatagcttct ctgtggcctc ctatttagct   6300

aagcagcagt gtttttggat actttttttt tctgtttgtg aataaggcca gcactcaaga   6360

tgggcagcca agggtgcact gactattagc tggcccatag gatatctgta aggctggtgg   6420

gacagttttg gacctggaat catgtgtaac taacaaggtt ggacgtttct tccccatcag   6480

ggtagaaaaa tcatctcaaa ctagccaaaa ggcagttttg gaaactacat tgggggacgt   6540

tatttttatt tatatatggg gcctaggcca atccaggatg gtagctggaa taccttcctt   6600

cttaaaatct gatcatggca gggatatgca gggcactttt tactatttgg ccttctaagc   6660

agattgggaa ggaggtattt tctggttttc gctttcctcc gacttaatag gacttgcctt   6720

ctccctgggc agggagagag gctgggttgg tgctctccct tactctactc atactgactt   6780

agagcctctg gctgctgttt gggcatccaa gaaagggagg ggaaggaatg agctaaaaac   6840

aaaacagaat gaggtgggaa agggagattt tcttctttac agaggaaaat aggaaaccct   6900

ccaagaattg tgcaagtaaa gacatttgtt gaatgcactg agtcccttgg tgtagtagca   6960

ataaggaaaa atgaaattac tttcctgtgc acacagtcca gcctaattgg tatgtgatgt   7020

tgcacttagc agccatgtgg tgggcatgtg tgactactct ggttttcact ttagtttcta   7080

aactttttat ccctctcaag tccagcatgg atggggaaat gtctctggat ccccacagct   7140

gtgtacttgt ttgcatttgt ttccctttga gatttgtgtt tgtgtcctgc tttgagctgt   7200

accttgtcca gtccattgtg aaattatccc agcagctgta atgtacagtt ccttctgaag   7260

caagcaacat cagcagcagc agcagcagca gcacaattct gtgttttata aagacaacag   7320

tggcttctat ttctaaagtg cggtctttct cttttttttt cctaccagca aaacaaactt   7380

ttgggactga ttacatctct aatagatttt aggtgagaat aatactgtag attgttatgc   7440

aggaatactt cacagagcct tcatttattc ttcattcaac aaacatgcaa agcactgtgc   7500

cagcagtatt gtggggaggg gaggcacaat tcaaaatgag gaaaatagtg tccgtctcat   7560

taagggaatt aagtttggtg ggggatatga ttagccaaat agtcccctgg cataggagga   7620

agataatgag ggagtggaat aaggctacaa caacgaatat agggaggaag ggacagattt   7680

gagagacgag gtagaattaa taggactcga tggctggtgg gaggagaaga caggagtaga   7740

ggttagctcc caggtttctc cttgaccata ggagtgtgtt gggacattct gccagtcaag   7800

atgggggtga cggggagact gtagaaggaa ggtggggagt                         7840


<210>  5932
<211>  782
<212>  PRT
<213>  Homosapiens

<400>  5932

Met Val Gln His Phe Lys Pro Gln Ile Phe Gly Asp Arg Lys Pro Val 
1               5                   10                  15      


Tyr Asp Gly Lys Lys Asn Ile Tyr Thr Val Thr Ala Leu Pro Ile Gly 
            20                  25                  30          


Asn Glu Arg Val Asp Phe Glu Val Thr Ile Pro Gly Glu Gly Lys Asp 
        35                  40                  45              


Arg Ile Phe Lys Val Ser Ile Lys Trp Leu Ala Ile Val Ser Trp Arg 
    50                  55                  60                  


Met Leu His Glu Ala Leu Val Ser Gly Gln Ile Pro Val Pro Leu Glu 
65                  70                  75                  80  


Ser Val Gln Ala Leu Asp Val Ala Met Arg His Leu Ala Ser Met Arg 
                85                  90                  95      


Tyr Thr Pro Val Gly Arg Ser Phe Phe Ser Pro Pro Glu Gly Tyr Tyr 
            100                 105                 110         


His Pro Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser 
        115                 120                 125             


Val Arg Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala 
    130                 135                 140                 


Thr Ala Phe Tyr Lys Ala Gln Pro Val Ile Glu Phe Met Cys Glu Val 
145                 150                 155                 160 


Leu Asp Ile Arg Asn Ile Asp Glu Gln Pro Lys Pro Leu Thr Asp Ser 
                165                 170                 175     


Gln Arg Val Arg Phe Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Val 
            180                 185                 190         


Thr His Cys Gly Gln Met Lys Arg Lys Tyr Arg Val Cys Asn Val Thr 
        195                 200                 205             


Arg Arg Pro Ala Ser His Gln Thr Phe Pro Leu Gln Leu Glu Ser Gly 
    210                 215                 220                 


Gln Thr Val Glu Cys Thr Val Ala Gln Tyr Phe Lys Gln Lys Tyr Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu 
                245                 250                 255     


Gln Lys His Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly 
            260                 265                 270         


Gln Arg Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile 
        275                 280                 285             


Lys Ala Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg 
    290                 295                 300                 


Leu Met Lys Asn Ala Ser Tyr Asn Leu Asp Pro Tyr Ile Gln Glu Phe 
305                 310                 315                 320 


Gly Ile Lys Val Lys Asp Asp Met Thr Glu Val Thr Gly Arg Val Leu 
                325                 330                 335     


Pro Ala Pro Ile Leu Gln Tyr Gly Gly Arg Asn Arg Ala Ile Ala Thr 
            340                 345                 350         


Pro Asn Gln Gly Val Trp Asp Met Arg Gly Lys Gln Phe Tyr Asn Gly 
        355                 360                 365             


Ile Glu Ile Lys Val Trp Ala Ile Ala Cys Phe Ala Pro Gln Lys Gln 
    370                 375                 380                 


Cys Arg Glu Glu Val Leu Lys Asn Phe Thr Asp Gln Leu Arg Lys Ile 
385                 390                 395                 400 


Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys 
                405                 410                 415     


Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys 
            420                 425                 430         


Asn Thr Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys 
        435                 440                 445             


Thr Pro Val Tyr Ala Glu Val Lys Arg Val Gly Asp Thr Leu Leu Gly 
    450                 455                 460                 


Met Ala Thr Gln Cys Val Gln Val Lys Asn Val Val Lys Thr Ser Pro 
465                 470                 475                 480 


Gln Thr Leu Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly 
                485                 490                 495     


Ile Asn Asn Ile Leu Val Pro His Gln Arg Ser Ala Val Phe Gln Gln 
            500                 505                 510         


Pro Val Ile Phe Leu Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp 
        515                 520                 525             


Gly Lys Lys Pro Ser Ile Thr Ala Val Val Gly Ser Met Asp Ala His 
    530                 535                 540                 


Pro Ser Arg Tyr Cys Ala Thr Val Arg Val Gln Arg Pro Arg Gln Glu 
545                 550                 555                 560 


Ile Ile Glu Asp Leu Ser Tyr Met Val Arg Glu Leu Leu Ile Gln Phe 
                565                 570                 575     


Tyr Lys Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp 
            580                 585                 590         


Gly Val Pro Glu Gly Gln Leu Pro Gln Ile Leu His Tyr Glu Leu Leu 
        595                 600                 605             


Ala Ile Arg Asp Ala Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly 
    610                 615                 620                 


Ile Thr Tyr Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys 
625                 630                 635                 640 


Ala Asp Lys Asn Glu Arg Ile Gly Lys Ser Gly Asn Ile Pro Ala Gly 
                645                 650                 655     


Thr Thr Val Asp Thr Asn Ile Thr His Pro Phe Glu Phe Asp Phe Tyr 
            660                 665                 670         


Leu Cys Ser His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr 
        675                 680                 685             


Tyr Val Leu Trp Asp Asp Asn Arg Phe Thr Ala Asp Glu Leu Gln Ile 
    690                 695                 700                 


Leu Thr Tyr Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val 
705                 710                 715                 720 


Ser Ile Pro Ala Pro Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala 
                725                 730                 735     


Arg Tyr His Leu Val Asp Lys Glu His Asp Ser Gly Glu Gly Ser His 
            740                 745                 750         


Ile Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala 
        755                 760                 765             


Val Gln Val His Gln Asp Thr Leu Arg Thr Met Tyr Phe Ala 
    770                 775                 780         


<210>  5933
<211>  7982
<212>  DNA
<213>  Homosapiens

<400>  5933
actggcagct ggccgggcgc tcgcagtggg agctgctgca ggctccgcgg cggcggcaac     60

ggaggctgcg ggggcggcgg cgcgagcggc cgggcttggt aggggagccg agcccggccc    120

gggatcccga gcagcgagag tgtggggtac ctaggcccct cacgctggac ttcacagtct    180

ccgggccgcc tgacctccgc acgggtatat gggatggaag cgggaccctc gggagcagct    240

gcgggcgctt acctgccccc cctgcagcag gtgttccagg cacctcgccg gcctggcatt    300

ggcactgtgg ggaaaccaat caagctcctg gccaattact ttgaggtgga catccctaag    360

atcgacgtgt accactacga ggtggacatc aagccggata agtgtccccg tagagtcaac    420

cgggaagtgg tggaatacat ggtccagcat ttcaagcctc agatctttgg tgatcgcaag    480

cctgtgtatg atggaaagaa gaacatttac actgtcacag cactgcccat tggcaacgaa    540

cgggtcgact ttgaggtgac aatccctggg gaagggaagg atcgaatctt taaggtctcc    600

atcaagtggc tagccattgt gagctggcga atgctgcatg aggccctggt cagcggccag    660

atccctgttc ccttggagtc tgtgcaagcc ctggatgtgg ccatgaggca cctggcatcc    720

atgaggtaca cccctgtggg ccgctccttc ttctcaccgc ctgagggcta ctaccacccg    780

ctggggggtg ggcgcgaggt ctggttcggc tttcaccagt ctgtgcgccc tgccatgtgg    840

aagatgatgc tcaacattga tgtctcagcc actgcctttt ataaggcaca gccagtgatt    900

gagttcatgt gtgaggtgct ggacatcagg aacatagatg agcagcccaa gcccctcacg    960

gactctcagc gcgttcgctt caccaaggag atcaagggcc tgaaggtgga agtcacccac   1020

tgtggacaga tgaagaggaa gtaccgcgtg tgtaatgtta cccgtcgccc tgctagccat   1080

cagacattcc ccttacagct ggagagtgga cagactgtgg agtgcacagt ggcacagtat   1140

ttcaagcaga aatataacct tcagctcaag tatccccatc tgccctgcct acaagttggc   1200

caggaacaaa agcataccta ccttccccta gaggtctgta acattgtggc tgggcagcgc   1260

tgtattaaaa agctgaccga caaccagacc tcgaccatga taaaggccac agctagatcc   1320

gctccagaca gacaggagga gatcagtcgc ctgatgaaga atgccagcta caacttagat   1380

ccctacatcc aggaatttgg gatcaaagtg aaggatgaca tgacggaggt gacagggcga   1440

gtgctgccgg cgcccatctt gcagtacggc ggccggaacc gggccattgc cacacccaat   1500

cagggtgtct gggacatgcg ggggaaacag ttctacaatg ggattgagat caaagtctgg   1560

gccatcgcct gcttcgcacc ccaaaaacag tgtcgagaag aggtgctcaa gaacttcaca   1620

gaccagctgc ggaagatttc caaggatgcg gggatgccta tccagggtca accttgtttc   1680

tgcaaatatg cacagggggc agacagcgtg gagcctatgt tccggcatct caagaacacc   1740

tactcagggc tgcagctcat tattgtcatc ctgccaggga agacgccggt gtatgctgag   1800

gtgaaacgtg tcggagatac actcttggga atggctacgc agtgtgtgca ggtgaagaac   1860

gtggtcaaga cctcacctca gactctgtcc aacctctgcc tcaagatcaa tgtcaaactt   1920

ggtggcatta acaacatcct agtcccacac cagcgctctg ccgtttttca acagccagtg   1980

atattcctgg gagcagatgt tacacacccc ccagcagggg atgggaaaaa accttctatc   2040

acagcagtgg taggcagtat ggatgcccac cccagccgat actgtgctac tgtgcgggta   2100

cagcgaccac ggcaagagat cattgaagac ttgtcctaca tggtgcgtga gctcctcatc   2160

caattctaca agtccacccg tttcaagcct acccgcatca tcttctaccg agatggggtg   2220

cctgaaggcc agctacccca gatactccac tatgagctac tggccattcg tgatgcctgc   2280

atcaaactgg aaaaggacta ccagcctggg atcacttata ttgtggtgca gaaacgccat   2340

cacacccgcc ttttctgtgc tgacaagaat gagcgaattg ggaagagtgg taacatccca   2400

gctgggacca cagtggacac caacatcacc cacccatttg agtttgactt ctatctgtgc   2460

agccacgcag gcatccaggg caccagccga ccatcccatt actatgttct ttgggatgac   2520

aaccgtttca cagcagatga gctccagatc ctgacgtacc agctgtgcca cacttacgta   2580

cgatgcacac gctctgtctc tatcccagca cctgcctact atgcccgcct ggtggctttc   2640

cgggcacgat accacctggt ggacaaggag catgacagtg gagaggggag ccacatatcg   2700

gggcagagca atgggcggga cccccaggcc ctggccaaag ccgtgcaggt tcaccaggat   2760

actctgcgca ccatgtactt cgcttgaagg cagaacgctg ttacctcact ggatagaaga   2820

aagctttcca agccccagga gctgtgccac ccaaatccag aggaagcaag gaggagggag   2880

gtggggtagg gaggagtgta ggatgccttg tttccttcta tagaggtggt gtaagagtgg   2940

ggaacagggc cagcaagaca gaccaccagc cagaaatctc tgatatcaac ctcatgtccc   3000

ccacccctca ccccatcttg tcacatctgg ccctgacccc actggaccaa aaggggcagc   3060

actggtgccc accatacaca caggtgtctc atgtgactca cagtgctaaa gactcatgct   3120

tgacagcttg gtaaggtcaa ctctgtagcc ctgcagacaa aagctggtta ggtttgggtt   3180

tgatacttta gatgggaaag tgaggggctt gagaaagtgg gtgggaggag ggaaggattt   3240

tttaggagcc ttaatcagaa aaggactaga tttgtttaag aagaaaaatg aaaccagacc   3300

cagatcaata ttttaggata ctagatgttt taatgggttc agaatccagt ttgtaggaag   3360

attttttaat ggttttggtt gctcctcccc cagctgccac cccccacctt acccttattc   3420

ctctctgtcc acattttctg ccccacctta cttctcctcc ctgacagaca tccagcccct   3480

agtaatactt aaggcactat ggcacttagc tttgaagtga cacgaccctg tcttccttcc   3540

gcccgctggt gggtaaccag tgccttccct gtaacggtaa tgctgcagaa ctgcaacctt   3600

ttgtaccttt ctttggggaa tggggtgggg gtgggagagg aggtagatgg ggaagaaata   3660

ccccagaccc aacaaacctc cagccagaaa gccagctatt ttgcatttga aggaattgac   3720

ttcctcattc attgagcttt ttaaaagatc acaacctcaa gatggttaaa atccattgac   3780

atttgcactt tcaaacatga caagtctcgg agctgctgag atgacaggcc cctggccttt   3840

ccacttatgc ctccttttct ccttattcct cctacctccc gccccgccca ggtctggagt   3900

tactttcata gcatttttca ctcttggctt cttttctccc ttgatggtca agtctcttat   3960

gtttcaatat ttcttaactg gggtgtctta taacaaaaaa ctcttaggtc taaaatgaga   4020

aaaaagagag aaaacaaaat gttattttta taccataact tgagtgtatt gccaaaattt   4080

ggaaatcctt cccatgcctg atgagtttat atcccagaaa cattgagcca tcagaatgaa   4140

ctgtgtacct gatttgttct ctgacctggc taggtaggga gggggtggtt atcgccccaa   4200

gatggggtcc aggctccatc cttcctctgt gcagataata cctttttctt gctatagcct   4260

ccctcctctg cactgtcctg cactctttct tgcaagtgca tctttttcct tcccctggac   4320

tgtcctctga ccctttggct catcctagat tgcagtgtgt cctgtggaca ggctggggaa   4380

ttttgctgct ccctattgct tctgtttaca aaaatgaatt tttcctggtt tcccactagg   4440

gcatgtgggt gggtggcatg gacttttttt tttttttttt tttgtcttga gacatggggt   4500

ttggctgtct tgcaggactg gagaaggtgg tggttctagc ttggtctctg ttggccttga   4560

agcaagcatc ccccctgccc tttttccttg actgttcatt tttttcctgc cccactgctt   4620

gggatgggga gttgcaactt cagtgtggaa tttcctcttt gaggagcctg ggcttggatc   4680

tatcctgatc tggtgatgaa gccatgatta ctttagacct agcccaggct tggaggccag   4740

ctggaggaag aagggtctaa atcctggcct gtagagttag aactaccatt tcctcccctt   4800

agctgccctt gtatgacccg gatttgctat gcaaaacaat ctatcccagg ttctgttctg   4860

gttggctaca ttgttcagca actcacaaaa cgtagcacaa acattcatta tggagaaagc   4920

atcaggactg ttgagtaact cctcctttac ttttttcctg ctggctacag catggggtgc   4980

cctataggca caagcccagc tgaagaacag aatggagggc tctgggagga ggcagctcac   5040

tggagagcct acattcctta cacaagtgcc taaagagagt gatgctaaca ctccatctgc   5100

cctgtccatt gccttcatat acagtctact tcgtgttctg tcaccctttg gggaggggag   5160

ttctcctggg acagtgggct ctgcatgttc tccacttgga tacattttgg ggctaggatc   5220

agggcactat tcctggaggg tccagtcatt caccagcatt tgcaaatgtc catagggagc   5280

aggtggcagc ctctactccc agcaacaagt ttgtgttctc tccttttctc tctttgcctc   5340

actctctcca gttggttttc agctggggct tgaaatgcat ttttagccct ttgacgtggc   5400

ttatgccatt caagaaataa aaagcaagag aatcagcttt gggcaatgac aagaaatgag   5460

ttcttactct gatttttttg taaaaagata atttttgaga cttgaaaaat accccgacct   5520

tgagattatt cctgtttgaa aggtggtgca tgcagatgga gaagtggtgt tggcagcaag   5580

ctttggctca tgtggatttg gtttaagtgg tgcttcttac ccaagcttca aggaagtgct   5640

tgggggaccc ccagcctcat cctcttagtt gggtctcttg ttccctttgt accactgttt   5700

tgccttcctt ttcctcttct ctctttgcct ggcttccttt cccttttctt ctattcactc   5760

tgcttgcttg ctggccggcc tgcctgcctg cctgcctgcc tgcctgcctg tctgcctatg   5820

tgatgatgaa atctctgcat ggctgcaatg atcccactgt tagctggcag ggtcaggctt   5880

agctccttga ctgcagaaga ccaagaacct gttccccaag cccagagatg tccacctggg   5940

ctggactgcc ctcaagctta tactagagaa gagcaactga cctgcccaac ttgtgtgaag   6000

tcaggagggt ttctggcatt ttccacacct gtccactcct tggagctggt ttctctcatt   6060

gctttttcta aatctggttc tttttctctt tacctggggc ctggcttttc tgagattgtc   6120

ttagggttga gctatttggg tatcctgggt ttgagtgtta ggggatggac ataaaggaaa   6180

aagagtgatg agaagagaat ggagagaatt tgaataaaag gtgggaaagg agagcactgt   6240

tctttgattg tttatccagt ccaacctgat ccattaggga tcgaggtgct acactggcct   6300

ccagggataa gcctggggct actgttgctg ggaacttagg cttaacataa agccgaagaa   6360

ggtacctaga aatttgaaac ttccctaaaa agctcctaat gcccacctgc tagatagctt   6420

ctctgtggcc tcctatttag ctaagcagca gtgtttttgg atactttttt tttctgtttg   6480

tgaataaggc cagcactcaa gatgggcagc caagggtgca ctgactatta gctggcccat   6540

aggatatctg taaggctggt gggacagttt tggacctgga atcatgtgta actaacaagg   6600

ttggacgttt cttccccatc agggtagaaa aatcatctca aactagccaa aaggcagttt   6660

tggaaactac attgggggac gttattttta tttatatatg gggcctaggc caatccagga   6720

tggtagctgg aataccttcc ttcttaaaat ctgatcatgg cagggatatg cagggcactt   6780

tttactattt ggccttctaa gcagattggg aaggaggtat tttctggttt tcgctttcct   6840

ccgacttaat aggacttgcc ttctccctgg gcagggagag aggctgggtt ggtgctctcc   6900

cttactctac tcatactgac ttagagcctc tggctgctgt ttgggcatcc aagaaaggga   6960

ggggaaggaa tgagctaaaa acaaaacaga atgaggtggg aaagggagat tttcttcttt   7020

acagaggaaa ataggaaacc ctccaagaat tgtgcaagta aagacatttg ttgaatgcac   7080

tgagtccctt ggtgtagtag caataaggaa aaatgaaatt actttcctgt gcacacagtc   7140

cagcctaatt ggtatgtgat gttgcactta gcagccatgt ggtgggcatg tgtgactact   7200

ctggttttca ctttagtttc taaacttttt atccctctca agtccagcat ggatggggaa   7260

atgtctctgg atccccacag ctgtgtactt gtttgcattt gtttcccttt gagatttgtg   7320

tttgtgtcct gctttgagct gtaccttgtc cagtccattg tgaaattatc ccagcagctg   7380

taatgtacag ttccttctga agcaagcaac atcagcagca gcagcagcag cagcacaatt   7440

ctgtgtttta taaagacaac agtggcttct atttctaaag tgcggtcttt ctcttttttt   7500

ttcctaccag caaaacaaac ttttgggact gattacatct ctaatagatt ttaggtgaga   7560

ataatactgt agattgttat gcaggaatac ttcacagagc cttcatttat tcttcattca   7620

acaaacatgc aaagcactgt gccagcagta ttgtggggag gggaggcaca attcaaaatg   7680

aggaaaatag tgtccgtctc attaagggaa ttaagtttgg tgggggatat gattagccaa   7740

atagtcccct ggcataggag gaagataatg agggagtgga ataaggctac aacaacgaat   7800

atagggagga agggacagat ttgagagacg aggtagaatt aataggactc gatggctggt   7860

gggaggagaa gacaggagta gaggttagct cccaggtttc tccttgacca taggagtgtg   7920

ttgggacatt ctgccagtca agatgggggt gacggggaga ctgtagaagg aaggtgggga   7980

gt                                                                  7982


<210>  5934
<211>  857
<212>  PRT
<213>  Homosapiens

<400>  5934

Met Glu Ala Gly Pro Ser Gly Ala Ala Ala Gly Ala Tyr Leu Pro Pro 
1               5                   10                  15      


Leu Gln Gln Val Phe Gln Ala Pro Arg Arg Pro Gly Ile Gly Thr Val 
            20                  25                  30          


Gly Lys Pro Ile Lys Leu Leu Ala Asn Tyr Phe Glu Val Asp Ile Pro 
        35                  40                  45              


Lys Ile Asp Val Tyr His Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys 
    50                  55                  60                  


Pro Arg Arg Val Asn Arg Glu Val Val Glu Tyr Met Val Gln His Phe 
65                  70                  75                  80  


Lys Pro Gln Ile Phe Gly Asp Arg Lys Pro Val Tyr Asp Gly Lys Lys 
                85                  90                  95      


Asn Ile Tyr Thr Val Thr Ala Leu Pro Ile Gly Asn Glu Arg Val Asp 
            100                 105                 110         


Phe Glu Val Thr Ile Pro Gly Glu Gly Lys Asp Arg Ile Phe Lys Val 
        115                 120                 125             


Ser Ile Lys Trp Leu Ala Ile Val Ser Trp Arg Met Leu His Glu Ala 
    130                 135                 140                 


Leu Val Ser Gly Gln Ile Pro Val Pro Leu Glu Ser Val Gln Ala Leu 
145                 150                 155                 160 


Asp Val Ala Met Arg His Leu Ala Ser Met Arg Tyr Thr Pro Val Gly 
                165                 170                 175     


Arg Ser Phe Phe Ser Pro Pro Glu Gly Tyr Tyr His Pro Leu Gly Gly 
            180                 185                 190         


Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg Pro Ala Met 
        195                 200                 205             


Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Thr Ala Phe Tyr Lys 
    210                 215                 220                 


Ala Gln Pro Val Ile Glu Phe Met Cys Glu Val Leu Asp Ile Arg Asn 
225                 230                 235                 240 


Ile Asp Glu Gln Pro Lys Pro Leu Thr Asp Ser Gln Arg Val Arg Phe 
                245                 250                 255     


Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Val Thr His Cys Gly Gln 
            260                 265                 270         


Met Lys Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg Pro Ala Ser 
        275                 280                 285             


His Gln Thr Phe Pro Leu Gln Leu Glu Ser Gly Gln Thr Val Glu Cys 
    290                 295                 300                 


Thr Val Ala Gln Tyr Phe Lys Gln Lys Tyr Asn Leu Gln Leu Lys Tyr 
305                 310                 315                 320 


Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys His Thr Tyr 
                325                 330                 335     


Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg Cys Ile Lys 
            340                 345                 350         


Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile Lys Ala Thr Ala Arg 
        355                 360                 365             


Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg Leu Met Lys Asn Ala 
    370                 375                 380                 


Ser Tyr Asn Leu Asp Pro Tyr Ile Gln Glu Phe Gly Ile Lys Val Lys 
385                 390                 395                 400 


Asp Asp Met Thr Glu Val Thr Gly Arg Val Leu Pro Ala Pro Ile Leu 
                405                 410                 415     


Gln Tyr Gly Gly Arg Asn Arg Ala Ile Ala Thr Pro Asn Gln Gly Val 
            420                 425                 430         


Trp Asp Met Arg Gly Lys Gln Phe Tyr Asn Gly Ile Glu Ile Lys Val 
        435                 440                 445             


Trp Ala Ile Ala Cys Phe Ala Pro Gln Lys Gln Cys Arg Glu Glu Val 
    450                 455                 460                 


Leu Lys Asn Phe Thr Asp Gln Leu Arg Lys Ile Ser Lys Asp Ala Gly 
465                 470                 475                 480 


Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala Gln Gly Ala 
                485                 490                 495     


Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Thr Tyr Ser Gly 
            500                 505                 510         


Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys Thr Pro Val Tyr Ala 
        515                 520                 525             


Glu Val Lys Arg Val Gly Asp Thr Leu Leu Gly Met Ala Thr Gln Cys 
    530                 535                 540                 


Val Gln Val Lys Asn Val Val Lys Thr Ser Pro Gln Thr Leu Ser Asn 
545                 550                 555                 560 


Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Ile Asn Asn Ile Leu 
                565                 570                 575     


Val Pro His Gln Arg Ser Ala Val Phe Gln Gln Pro Val Ile Phe Leu 
            580                 585                 590         


Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp Gly Lys Lys Pro Ser 
        595                 600                 605             


Ile Thr Ala Val Val Gly Ser Met Asp Ala His Pro Ser Arg Tyr Cys 
    610                 615                 620                 


Ala Thr Val Arg Val Gln Arg Pro Arg Gln Glu Ile Ile Glu Asp Leu 
625                 630                 635                 640 


Ser Tyr Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys Ser Thr Arg 
                645                 650                 655     


Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp Gly Val Pro Glu Gly 
            660                 665                 670         


Gln Leu Pro Gln Ile Leu His Tyr Glu Leu Leu Ala Ile Arg Asp Ala 
        675                 680                 685             


Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly Ile Thr Tyr Ile Val 
    690                 695                 700                 


Val Gln Lys Arg His His Thr Arg Leu Phe Cys Ala Asp Lys Asn Glu 
705                 710                 715                 720 


Arg Ile Gly Lys Ser Gly Asn Ile Pro Ala Gly Thr Thr Val Asp Thr 
                725                 730                 735     


Asn Ile Thr His Pro Phe Glu Phe Asp Phe Tyr Leu Cys Ser His Ala 
            740                 745                 750         


Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr Tyr Val Leu Trp Asp 
        755                 760                 765             


Asp Asn Arg Phe Thr Ala Asp Glu Leu Gln Ile Leu Thr Tyr Gln Leu 
    770                 775                 780                 


Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile Pro Ala Pro 
785                 790                 795                 800 


Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala Arg Tyr His Leu Val 
                805                 810                 815     


Asp Lys Glu His Asp Ser Gly Glu Gly Ser His Ile Ser Gly Gln Ser 
            820                 825                 830         


Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val Gln Val His Gln 
        835                 840                 845             


Asp Thr Leu Arg Thr Met Tyr Phe Ala 
    850                 855         


<210>  5935
<211>  4132
<212>  DNA
<213>  Homosapiens

<400>  5935
agctggccgg gcgctcgcag tgggagctgc tgcaggctcc gcggcggcgg caacggaggc     60

tgcgggggcg gcggcgcgag cggccgggct tggtagggga gccgagcccg gcccgggatc    120

ccgagcagcg agagtgtggg gtacctaggc ccctcacgct ggacttcaca gtctccgggc    180

cgcctgacct ccgcacgggt atatgggatg gaagcgggac cctcgggagc agctgcgggc    240

gcttacctgc cccccctgca gcaggtgttc caggcacctc gccggcctgg cattggcact    300

gtggggaaac caatcaagct cctggccaat tactttgagg tggacatccc taagatcgac    360

gtgtaccact acgaggtgga catcaagccg gataagtgtc cccgtagagt caaccgggaa    420

gtggtggaat acatggtcca gcatttcaag cctcagatct ttggtgatcg caagcctgtg    480

tatgatggaa agaagaacat ttacactgtc acagcactgc ccattggcaa cgaacgggtc    540

gactttgagg tgacaatccc tggggaaggg aaggatcgaa tctttaaggt ctccatcaag    600

tggctagcca ttgtgagctg gcgaatgctg catgaggccc tggtcagcgg ccagatccct    660

gttcccttgg agtctgtgca agccctggat gtggccatga ggcacctggc atccatgagg    720

tacacccctg tgggccgctc cttcttctca ccgcctgagg gctactacca cccgctgggg    780

ggtgggcgcg aggtctggtt cggctttcac cagtctgtgc gccctgccat gtggaagatg    840

atgctcaaca ttgatgtctc agccactgcc ttttataagg cacagccagt gattgagttc    900

atgtgtgagg tgctggacat caggaacata gatgagcagc ccaagcccct cacggactct    960

cagcgcgttc gcttcaccaa ggagatcaag ggcctgaagg tggaagtcac ccactgtgga   1020

cagatgaaga ggaagtaccg cgtgtgtaat gttacccgtc gccctgctag ccatcagaca   1080

ttccccttac agctggagag tggacagact gtggagtgca cagtggcaca gtatttcaag   1140

cagaaatata accttcagct caagtatccc catctgccct gcctacaagt tggccaggaa   1200

caaaagcata cctaccttcc cctagaggtc tgtaacattg tggctgggca gcgctgtatt   1260

aaaaagctga ccgacaacca gacctcgacc atgataaagg ccacagctag atccgctcca   1320

gacagacagg aggagatcag tcgcctgatg aagaatgcca gctacaactt agatccctac   1380

atccaggaat ttgggatcaa agtgaaggat gacatgacgg aggtgacagg gcgagtgctg   1440

ccggcgccca tcttgcagta cggcggccgg aaccgggcca ttgccacacc caatcagggt   1500

gtctgggaca tgcgggggaa acagttctac aatgggattg agatcaaagt ctgggccatc   1560

gcctgcttcg caccccaaaa acagtgtcga gaagaggtgc tcaagaactt cacagaccag   1620

ctgcggaaga tttccaagga tgcggggatg cctatccagg gtcaaccttg tttctgcaaa   1680

tatgcacagg gggcagacag cgtggagcct atgttccggc atctcaagaa cacctactca   1740

gggctgcagc tcattattgt catcctgcca gggaagacgc cggtgtatgc tgaggtgaaa   1800

cgtgtcggag atacactctt gggaatggct acgcagtgtg tgcaggtgaa gaacgtggtc   1860

aagacctcac ctcagactct gtccaacctc tgcctcaaga tcaatgtcaa acttggtggc   1920

attaacaaca tcctagtccc acaccagcgc tctgccgttt ttcaacagcc agtgatattc   1980

ctgggagcag atgttacaca ccccccagca ggggatggga aaaaaccttc tatcacagca   2040

gtggtaggca gtatggatgc ccaccccagc cgatactgtg ctactgtgcg ggtacagcga   2100

ccacggcaag agatcattga agacttgtcc tacatggtgc gtgagctcct catccaattc   2160

tacaagtcca cccgtttcaa gcctacccgc atcatcttct accgagatgg ggtgcctgaa   2220

ggccagctac cccagatact ccactatgag ctactggcca ttcgtgatgc ctgcatcaaa   2280

ctggaaaagg actaccagcc tgggatcact tatattgtgg tgcagaaacg ccatcacacc   2340

cgccttttct gtgctgacaa gaatgagcga attgggaaga gtggtaacat cccagctggg   2400

accacagtgg acaccaacat cacccaccca tttgagtttg acttctatct gtgcagccac   2460

gcaggcatcc agggcaccag ccgaccatcc cattactatg ttctttggga tgacaaccgt   2520

ttcacagcag atgagctcca gatcctgacg taccagctgt gccacactta cgtacgatgc   2580

acacgctctg tctctatccc agcacctgcc tactatgccc gcctggtggc tttccgggca   2640

cgataccacc tggtggacaa ggagcatgac agtggagagg ggagccacat atcggggcag   2700

agcaatgggc gggaccccca ggccctggcc aaagccgtgc aggttcacca ggatactctg   2760

cgcaccatgt acttcgcttg aaggcagaac gctgttacct cactggatag aagaaagctt   2820

tccaagcccc aggagctgtg ccacccaaat ccagaggaag caaggaggag ggaggtgggg   2880

tagggaggag tgtaggatgc cttgtttcct tctatagagg tggtgtaaga gtggggaaca   2940

gggccagcaa gacagaccac cagccagaaa tctctgatat caacctcatg tcccccaccc   3000

ctcaccccat cttgtcacat ctggccctga ccccactgga ccaaaagggg cagcactggt   3060

gcccaccata cacacaggtg tctcatgtga ctcacagtgc taaagactca tgcttgacag   3120

cttggtaagg tcaactctgt agccctgcag acaaaagctg gttaggtttg ggtttgatac   3180

tttagatggg aaagtgaggg gcttgagaaa gtgggtggga ggagggaagg attttttagg   3240

agccttaatc agaaaaggac tagatttgtt taagaagaaa aatgaaacca gacccagatc   3300

aatattttag gatactagat gttttaatgg gttcagaatc cagtttgtag gaagattttt   3360

taatggtttt ggttgctcct cccccagctg ccacccccca ccttaccctt attcctctct   3420

gtccacattt tctgccccac cttacttctc ctccctgaca gacatccagc ccctagtaat   3480

acttaaggca ctatggcact tagctttgaa gtgacacgac cctgtcttcc ttccgcccgc   3540

tggtgggtaa ccagtgcctt ccctgtaacg gtaatgctgc agaactgcaa ccttttgtac   3600

ctttctttgg ggaatggggt gggggtggga gaggaggtag atggggaaga aataccccag   3660

acccaacaaa cctccagcca gaaagccagc tattttgcat ttgaaggaat tgacttcctc   3720

attcattgag ctttttaaaa gatcacaacc tcaagatggt taaaatccat tgacatttgc   3780

actttcaaac atgacaagtc tcggagctgc tgagatgaca ggcccctggc ctttccactt   3840

atgcctcctt ttctccttat tcctcctacc tcccgccccg cccaggtctg gagttacttt   3900

catagcattt ttcactcttg gcttcttttc tcccttgatg gtcaagtctc ttatgtttca   3960

atatttctta actggggtgt cttataacaa aaaactctta ggtctaaaat gagaaaaaag   4020

agagaaaaca aaatgttatt tttataccat aacttgagtg tattgccaaa atttggaaat   4080

ccttcccatg cctgatgagt ttatatccca gaaacattga gccatcagaa tg           4132


<210>  5936
<211>  857
<212>  PRT
<213>  Homosapiens

<400>  5936

Met Glu Ala Gly Pro Ser Gly Ala Ala Ala Gly Ala Tyr Leu Pro Pro 
1               5                   10                  15      


Leu Gln Gln Val Phe Gln Ala Pro Arg Arg Pro Gly Ile Gly Thr Val 
            20                  25                  30          


Gly Lys Pro Ile Lys Leu Leu Ala Asn Tyr Phe Glu Val Asp Ile Pro 
        35                  40                  45              


Lys Ile Asp Val Tyr His Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys 
    50                  55                  60                  


Pro Arg Arg Val Asn Arg Glu Val Val Glu Tyr Met Val Gln His Phe 
65                  70                  75                  80  


Lys Pro Gln Ile Phe Gly Asp Arg Lys Pro Val Tyr Asp Gly Lys Lys 
                85                  90                  95      


Asn Ile Tyr Thr Val Thr Ala Leu Pro Ile Gly Asn Glu Arg Val Asp 
            100                 105                 110         


Phe Glu Val Thr Ile Pro Gly Glu Gly Lys Asp Arg Ile Phe Lys Val 
        115                 120                 125             


Ser Ile Lys Trp Leu Ala Ile Val Ser Trp Arg Met Leu His Glu Ala 
    130                 135                 140                 


Leu Val Ser Gly Gln Ile Pro Val Pro Leu Glu Ser Val Gln Ala Leu 
145                 150                 155                 160 


Asp Val Ala Met Arg His Leu Ala Ser Met Arg Tyr Thr Pro Val Gly 
                165                 170                 175     


Arg Ser Phe Phe Ser Pro Pro Glu Gly Tyr Tyr His Pro Leu Gly Gly 
            180                 185                 190         


Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg Pro Ala Met 
        195                 200                 205             


Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Thr Ala Phe Tyr Lys 
    210                 215                 220                 


Ala Gln Pro Val Ile Glu Phe Met Cys Glu Val Leu Asp Ile Arg Asn 
225                 230                 235                 240 


Ile Asp Glu Gln Pro Lys Pro Leu Thr Asp Ser Gln Arg Val Arg Phe 
                245                 250                 255     


Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Val Thr His Cys Gly Gln 
            260                 265                 270         


Met Lys Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg Pro Ala Ser 
        275                 280                 285             


His Gln Thr Phe Pro Leu Gln Leu Glu Ser Gly Gln Thr Val Glu Cys 
    290                 295                 300                 


Thr Val Ala Gln Tyr Phe Lys Gln Lys Tyr Asn Leu Gln Leu Lys Tyr 
305                 310                 315                 320 


Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys His Thr Tyr 
                325                 330                 335     


Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg Cys Ile Lys 
            340                 345                 350         


Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile Lys Ala Thr Ala Arg 
        355                 360                 365             


Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg Leu Met Lys Asn Ala 
    370                 375                 380                 


Ser Tyr Asn Leu Asp Pro Tyr Ile Gln Glu Phe Gly Ile Lys Val Lys 
385                 390                 395                 400 


Asp Asp Met Thr Glu Val Thr Gly Arg Val Leu Pro Ala Pro Ile Leu 
                405                 410                 415     


Gln Tyr Gly Gly Arg Asn Arg Ala Ile Ala Thr Pro Asn Gln Gly Val 
            420                 425                 430         


Trp Asp Met Arg Gly Lys Gln Phe Tyr Asn Gly Ile Glu Ile Lys Val 
        435                 440                 445             


Trp Ala Ile Ala Cys Phe Ala Pro Gln Lys Gln Cys Arg Glu Glu Val 
    450                 455                 460                 


Leu Lys Asn Phe Thr Asp Gln Leu Arg Lys Ile Ser Lys Asp Ala Gly 
465                 470                 475                 480 


Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala Gln Gly Ala 
                485                 490                 495     


Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Thr Tyr Ser Gly 
            500                 505                 510         


Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys Thr Pro Val Tyr Ala 
        515                 520                 525             


Glu Val Lys Arg Val Gly Asp Thr Leu Leu Gly Met Ala Thr Gln Cys 
    530                 535                 540                 


Val Gln Val Lys Asn Val Val Lys Thr Ser Pro Gln Thr Leu Ser Asn 
545                 550                 555                 560 


Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Ile Asn Asn Ile Leu 
                565                 570                 575     


Val Pro His Gln Arg Ser Ala Val Phe Gln Gln Pro Val Ile Phe Leu 
            580                 585                 590         


Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp Gly Lys Lys Pro Ser 
        595                 600                 605             


Ile Thr Ala Val Val Gly Ser Met Asp Ala His Pro Ser Arg Tyr Cys 
    610                 615                 620                 


Ala Thr Val Arg Val Gln Arg Pro Arg Gln Glu Ile Ile Glu Asp Leu 
625                 630                 635                 640 


Ser Tyr Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys Ser Thr Arg 
                645                 650                 655     


Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp Gly Val Pro Glu Gly 
            660                 665                 670         


Gln Leu Pro Gln Ile Leu His Tyr Glu Leu Leu Ala Ile Arg Asp Ala 
        675                 680                 685             


Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly Ile Thr Tyr Ile Val 
    690                 695                 700                 


Val Gln Lys Arg His His Thr Arg Leu Phe Cys Ala Asp Lys Asn Glu 
705                 710                 715                 720 


Arg Ile Gly Lys Ser Gly Asn Ile Pro Ala Gly Thr Thr Val Asp Thr 
                725                 730                 735     


Asn Ile Thr His Pro Phe Glu Phe Asp Phe Tyr Leu Cys Ser His Ala 
            740                 745                 750         


Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr Tyr Val Leu Trp Asp 
        755                 760                 765             


Asp Asn Arg Phe Thr Ala Asp Glu Leu Gln Ile Leu Thr Tyr Gln Leu 
    770                 775                 780                 


Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile Pro Ala Pro 
785                 790                 795                 800 


Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala Arg Tyr His Leu Val 
                805                 810                 815     


Asp Lys Glu His Asp Ser Gly Glu Gly Ser His Ile Ser Gly Gln Ser 
            820                 825                 830         


Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val Gln Val His Gln 
        835                 840                 845             


Asp Thr Leu Arg Thr Met Tyr Phe Ala 
    850                 855         


<210>  5937
<211>  462
<212>  DNA
<213>  Homosapiens

<400>  5937
atccaatgtt ttggcttggg aatggtacag catgcttcgg aaaggcagta cttactcaga     60

attttccctt tcctgggctc aattatgtta cacttctctc tagcctcaaa tattttattg    120

ggacttcgag tttctttcat ttacatgcgg ttccttgatt ataccaccag tcagattctt    180

ctaaagaccc ttcaccatcc ctcctgggag gctgggtaaa atggcatcct cctagtgatg    240

gtcaaagcaa ggtcccattg gcttttggtt gccctgagag cgtagaagga cagtgtcaca    300

tttgccctgt tctgatcagg tactatacct atcttgtctt tagtatattt aattgcttcc    360

tctccactaa actgatatta ttgttttttt aatgtaaact ttttattaaa ttgtatatat    420

agaaatctta catgtttagc tcagtgatat ttcataaagt gt                       462


<210>  5938
<211>  65
<212>  PRT
<213>  Homosapiens

<400>  5938

Met Val Gln His Ala Ser Glu Arg Gln Tyr Leu Leu Arg Ile Phe Pro 
1               5                   10                  15      


Phe Leu Gly Ser Ile Met Leu His Phe Ser Leu Ala Ser Asn Ile Leu 
            20                  25                  30          


Leu Gly Leu Arg Val Ser Phe Ile Tyr Met Arg Phe Leu Asp Tyr Thr 
        35                  40                  45              


Thr Ser Gln Ile Leu Leu Lys Thr Leu His His Pro Ser Trp Glu Ala 
    50                  55                  60                  


Gly 
65  


<210>  5939
<211>  2473
<212>  DNA
<213>  Homosapiens

<400>  5939
aacaatctat cccaggttct gttctggttg gctacattgt tcagcaactc acaaaacgta     60

gcacaaacat tcattatgga gaaagcatca ggactgttga gtaactcctc ctttactttt    120

ttcctgctgg ctacagcatg gggtgcccta taggcacaag cccagctgaa gaacagaatg    180

gagggctctg ggaggaggca gctcactgga gagcctacat tccttacaca agtgcctaaa    240

gagagtgatg ctaacactcc atctgccctg tccattgcct tcatatacag tctacttcgt    300

gttctgtcac cctttgggga ggggagttct cctgggacag tgggctctgc atgttctcca    360

cttggataca ttttggggct aggatcaggg cactattcct ggagggtcca gtcattcacc    420

agcatttgca aatgtccata gggagcaggt ggcagcctct actcccagca acaagtttgt    480

gttctctcct tttctctctt tgcctcactc tctccagttg gttttcagct ggggcttgaa    540

atgcattttt agccctttga cgtggcttat gccattcaag aaataaaaag caagagaatc    600

agctttgggc aatgacaaga aatgagttct tactctgatt tttttgtaaa aagataattt    660

ttgagacttg aaaaataccc cgaccttgag attattcctg tttgaaaggt ggtgcatgca    720

gatggagaag tggtgttggc agcaagcttt ggctcatgtg gatttggttt aagtggtgct    780

tcttacccaa gcttcaagga agtgcttggg ggacccccag cctcatcctc ttagttgggt    840

ctcttgttcc ctttgtacca ctgttttgcc ttccttttcc tcttctctct ttgcctggct    900

tcctttccct tttcttctat tcactctgct tgctgggctg gactgccctc aagcttatac    960

tagagaagag caactgacct gcccaacttg tgtgaagtca ggagggtttc tggcattttc   1020

cacacctgtc cactccttgg agctggtttc tctcattgct ttttctaaat ctggttcttt   1080

ttctctttac ctggggcctg gcttttctga gattgtctta gggttgagct atttgggtat   1140

cctgggtttg agtgttaggg gatggacata aaggaaaaag agtgatgaga agagaatgga   1200

gagaatttga ataaaaggtg ggaaaggaga gcactgttct ttgattgttt atccagtcca   1260

acctgatcca ttagggatcg aggtgctaca ctggcctcca gggataagcc tggggctact   1320

gttgctggga acttaggctt aacataaagc cgaagaaggt acctagaaat ttgaaacttc   1380

cctaaaaagc tcctaatgcc cacctgctag atagcttctc tgtggcctcc tatttagcta   1440

agcagcagtg tttttggata cttttttttt ctgtttgtga ataaggccag cactcaagat   1500

gggcagccaa gggtgcactg actattagct ggcccatagg atatctgtaa ggctggtggg   1560

acagttttgg acctggaatc atgtgtaact aacaaggttg gacgtttctt ccccatcagg   1620

gtagaaaaat catctcaaac tagccaaaag gcagttttgg aaactacatt gggggacgtt   1680

atttttattt atatatgggg cctaggccaa tccaggatgg tagctggaat accttccttc   1740

ttaaaatctg atcatggcag ggatatgcag ggcacttttt actatttggc cttctaagca   1800

gattgggaag gaggtatttt ctggttttcg ctttcctccg acttaatagg acttgccttc   1860

tccctgggca gggagagagg ctgggttggt gctctccctt actctactca tactgactta   1920

gagcctctgg ctgctgtttg ggcatccaag aaagggaggg gaaggaatga gctaaaaaca   1980

aaacagaatg aggtgggaaa gggagatttt cttctttaca gaggaaaata ggaaaccctc   2040

caagaattgt gcaagtaaag acatttgttg aatgcactga gtcccttggt gtagtagcaa   2100

taaggaaaaa tgaaattact ttcctgtgca cacagtccag cctaattggt atgtgatgtt   2160

gcacttagca gccatgtggt gggcatgtgt gactactctg gttttcactt tagtttctaa   2220

actttttatc cctctcaagt ccagcatgga tggggaaatg tctctggatc cccacagctg   2280

tgtacttgtt tgcatttgtt tccctttgag atttgtgttt gtgtcctgct ttgagctgta   2340

ccttgtccag tccattgtga aattatccca gcagctgtaa tgtacagttc cttctgaagc   2400

aagcaacatc agcagcagca gcagcagcag cacaattctg tgttttataa agacaacagt   2460

ggcttctatt tct                                                      2473


<210>  5940
<211>  73
<212>  PRT
<213>  Homosapiens

<400>  5940

Met Trp Ile Trp Phe Lys Trp Cys Phe Leu Pro Lys Leu Gln Gly Ser 
1               5                   10                  15      


Ala Trp Gly Thr Pro Ser Leu Ile Leu Leu Val Gly Ser Leu Val Pro 
            20                  25                  30          


Phe Val Pro Leu Phe Cys Leu Pro Phe Pro Leu Leu Ser Leu Pro Gly 
        35                  40                  45              


Phe Leu Ser Leu Phe Phe Tyr Ser Leu Cys Leu Leu Gly Trp Thr Ala 
    50                  55                  60                  


Leu Lys Leu Ile Leu Glu Lys Ser Asn 
65                  70              


<210>  5941
<211>  2979
<212>  DNA
<213>  Homosapiens

<400>  5941
aacaatctat cccaggttct gttctggttg gctacattgt tcagcaactc acaaaacgta     60

gcacaaacat tcattatgga gaaagcatca ggactgttga gtaactcctc ctttactttt    120

ttcctgctgg ctacagcatg gggtgcccta taggcacaag cccagctgaa gaacagaatg    180

gagggctctg ggaggaggca gctcactgga gagcctacat tccttacaca agtgcctaaa    240

gagagtgatg ctaacactcc atctgccctg tccattgcct tcatatacag tctacttcgt    300

gttctgtcac cctttgggga ggggagttct cctgggacag tgggctctgc atgttctcca    360

cttggataca ttttggggct aggatcaggg cactattcct ggagggtcca gtcattcacc    420

agcatttgca aatgtccata gggagcaggt ggcagcctct actcccagca acaagtttgt    480

gttctctcct tttctctctt tgcctcactc tctccagttg gttttcagct ggggcttgaa    540

atgcattttt agccctttga cgtggcttat gccattcaag aaataaaaag caagagaatc    600

agctttgggc aatgacaaga aatgagttct tactctgatt tttttgtaaa aagataattt    660

ttgagacttg aaaaataccc cgaccttgag attattcctg tttgaaaggt ggtgcatgca    720

gatggagaag tggtgttggc agcaagcttt ggctcatgtg gatttggttt aagtggtgct    780

tcttacccaa gcttcaagga agtgcttggg ggacccccag cctcatcctc ttagttgggt    840

ctcttgttcc ctttgtacca ctgttttgcc ttccttttcc tcttctctct ttgcctggct    900

tcctttccct tttcttctat tcactctgct tgctgggctg gactgccctc aagcttatac    960

tagagaagag caactgacct gcccaacttg tgtgaagtca ggagggtttc tggcattttc   1020

cacacctgtc cactccttgg agctggtttc tctcattgct ttttctaaat ctggttcttt   1080

ttctctttac ctggggcctg gcttttctga gattgtctta gggttgagct atttgggtat   1140

cctgggtttg agtgttaggg gatggacata aaggaaaaag agtgatgaga agagaatgga   1200

gagaatttga ataaaaggtg ggaaaggaga gcactgttct ttgattgttt atccagtcca   1260

acctgatcca ttagggatcg aggtgctaca ctggcctcca gggataagcc tggggctact   1320

gttgctggga acttaggctt aacataaagc cgaagaaggt acctagaaat ttgaaacttc   1380

cctaaaaagc tcctaatgcc cacctgctag atagcttctc tgtggcctcc tatttagcta   1440

agcagcagtg tttttggata cttttttttt ctgtttgtga ataaggccag cactcaagat   1500

gggcagccaa gggtgcactg actattagct ggcccatagg atatctgtaa ggctggtggg   1560

acagttttgg acctggaatc atgtgtaact aacaaggttg gacgtttctt ccccatcagg   1620

gtagaaaaat catctcaaac tagccaaaag gcagttttgg aaactacatt gggggacgtt   1680

atttttattt atatatgggg cctaggccaa tccaggatgg tagctggaat accttccttc   1740

ttaaaatctg atcatggcag ggatatgcag ggcacttttt actatttggc cttctaagca   1800

gattgggaag gaggtatttt ctggttttcg ctttcctccg acttaatagg acttgccttc   1860

tccctgggca gggagagagg ctgggttggt gctctccctt actctactca tactgactta   1920

gagcctctgg ctgctgtttg ggcatccaag aaagggaggg gaaggaatga gctaaaaaca   1980

aaacagaatg aggtgggaaa gggagatttt cttctttaca gaggaaaata ggaaaccctc   2040

caagaattgt gcaagtaaag acatttgttg aatgcactga gtcccttggt gtagtagcaa   2100

taaggaaaaa tgaaattact ttcctgtgca cacagtccag cctaattggt atgtgatgtt   2160

gcacttagca gccatgtggt gggcatgtgt gactactctg gttttcactt tagtttctaa   2220

actttttatc cctctcaagt ccagcatgga tggggaaatg tctctggatc cccacagctg   2280

tgtacttgtt tgcatttgtt tccctttgag atttgtgttt gtgtcctgct ttgagctgta   2340

ccttgtccag tccattgtga aattatccca gcagctgtaa tgtacagttc cttctgaagc   2400

aagcaacatc agcagcagca gcagcagcag cacaattctg tgttttataa agacaacagt   2460

ggcttctatt tctaaagtgc ggtctttctc tttttttttc ctaccagcaa aacaaacttt   2520

tgggactgat tacatctcta atagatttta ggtgagaata atactgtaga ttgttatgca   2580

ggaatacttc acagagcctt catttattct tcattcaaca aacatgcaaa gcactgtgcc   2640

agcagtattg tggggagggg aggcacaatt caaaatgagg aaaatagtgt ccgtctcatt   2700

aagggaatta agtttggtgg gggatatgat tagccaaata gtcccctggc ataggaggaa   2760

gataatgagg gagtggaata aggctacaac aacgaatata gggaggaagg gacagatttg   2820

agagacgagg tagaattaat aggactcgat ggctggtggg aggagaagac aggagtagag   2880

gttagctccc aggtttctcc ttgaccatag gagtgtgttg ggacattctg ccagtcaaga   2940

tgggggtgac ggggagactg tagaaggaag gtggggagt                          2979


<210>  5942
<211>  73
<212>  PRT
<213>  Homosapiens

<400>  5942

Met Trp Ile Trp Phe Lys Trp Cys Phe Leu Pro Lys Leu Gln Gly Ser 
1               5                   10                  15      


Ala Trp Gly Thr Pro Ser Leu Ile Leu Leu Val Gly Ser Leu Val Pro 
            20                  25                  30          


Phe Val Pro Leu Phe Cys Leu Pro Phe Pro Leu Leu Ser Leu Pro Gly 
        35                  40                  45              


Phe Leu Ser Leu Phe Phe Tyr Ser Leu Cys Leu Leu Gly Trp Thr Ala 
    50                  55                  60                  


Leu Lys Leu Ile Leu Glu Lys Ser Asn 
65                  70              


<210>  5943
<211>  1726
<212>  DNA
<213>  Homosapiens

<400>  5943
aggaaggagg gtggccctac cccagcgggc tcggctcggg gcctccgcgg cagttcgggg     60

tccttcaccc gccggctcca gtcctgtgcc gttttccgtc cgcgactctt ccggcccaga    120

gctttcggag tgcggttgct caggggaagc cgtcgccgcc cccgcctcgg ggccgagtga    180

gagtgcccgt cgcgtcgcgc cgcgtcgccc cccgggccgc ctccttgccg ccagtggcgg    240

gctccgttct ccctcgaagc actcccccca gctccatgaa tggaaatcgg ctccgcagga    300

cccgctgggg cccagcccct actcatggtg cccagaagac ctggctatgg caccatgggc    360

aaacccatta aactgctggc taactgtttt caagttgaaa tcccaaagat tgatgtctac    420

ctctatgagg tagatattaa accagacaag tgtcctagga gagtgaacag ggaggtggtt    480

gactcaatgg ttcagcattt taaagtaact atatttggag accgtagacc agtttatgat    540

ggaaaaagaa gtctttacac cgccaatcca cttcctgtgg caactacagg ggtagattta    600

gacgttactt tacctgggga aggtggaaaa gatcgacctt tcaaggtgtc aatcaaattt    660

gtctctcggg tgagttggca cctactgcat gaagtactga caggacggac cttgcctgag    720

ccactggaat tagacaagcc aatcagcact aaccctgtcc atgccgttga tgtggtgcta    780

cgacatctgc cctccatgaa atacacacct gtggggcgtt catttttctc cgctccagaa    840

ggatatgacc accctctggg agggggcagg gaagtgtggt ttggattcca tcagtctgtt    900

cggcctgcca tgtggaaaat gatgcttaat atcgatgaaa gagacctctg gcagcagtgt    960

ggagaataga tagaggagaa aaaactaatc tgagaagcca gttaggaggc ttttcaatca   1020

ctagttcagg taagagatgg tgatggtcta atgtgggatg gagaggaagg attaagctga   1080

aaaaataggt ttaagaacca tgtccagaaa aaaaaaactt tgggtgtagt actggtacat   1140

ggaacggatt ggaaaaaaat agaccagagc tttactagat ttttgaaaga attgtttttg   1200

caaataaact acaagcctgg catatcagtc aaggttcaga acctagagaa gcagaaccag   1260

tacgaagtat agagagagag tttatgcaat tgtaggggct agctaggcaa gtctgaaatt   1320

ttgggggcag gctgtcagga agggcaggga aattcaggca tgggctgaag cagttatcta   1380

taagtggaat ttcttgctct cagggaagct tcagccctac ttttaagacc tttcacctaa   1440

ttgaatcagg cccatccaca ttattcagga taatctccat tacttaaagt caacagatta   1500

tggattttaa ttacatctac aaaatacctt catagcaaca cctagattag tgtttgatta   1560

aacaaatggc agctggtagc ctagcaagtt aacacattaa aaacaacacc tgccatgatg   1620

gcttacactt gtaatcccag cactttggga ggccaaagtg ggaggatcac ttgagattag   1680

gagtttgcga tcaggctgaa caacatagtg agacctgatc tctacc                  1726


<210>  5944
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  5944

Met Glu Ile Gly Ser Ala Gly Pro Ala Gly Ala Gln Pro Leu Leu Met 
1               5                   10                  15      


Val Pro Arg Arg Pro Gly Tyr Gly Thr Met Gly Lys Pro Ile Lys Leu 
            20                  25                  30          


Leu Ala Asn Cys Phe Gln Val Glu Ile Pro Lys Ile Asp Val Tyr Leu 
        35                  40                  45              


Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys Pro Arg Arg Val Asn Arg 
    50                  55                  60                  


Glu Val Val Asp Ser Met Val Gln His Phe Lys Val Thr Ile Phe Gly 
65                  70                  75                  80  


Asp Arg Arg Pro Val Tyr Asp Gly Lys Arg Ser Leu Tyr Thr Ala Asn 
                85                  90                  95      


Pro Leu Pro Val Ala Thr Thr Gly Val Asp Leu Asp Val Thr Leu Pro 
            100                 105                 110         


Gly Glu Gly Gly Lys Asp Arg Pro Phe Lys Val Ser Ile Lys Phe Val 
        115                 120                 125             


Ser Arg Val Ser Trp His Leu Leu His Glu Val Leu Thr Gly Arg Thr 
    130                 135                 140                 


Leu Pro Glu Pro Leu Glu Leu Asp Lys Pro Ile Ser Thr Asn Pro Val 
145                 150                 155                 160 


His Ala Val Asp Val Val Leu Arg His Leu Pro Ser Met Lys Tyr Thr 
                165                 170                 175     


Pro Val Gly Arg Ser Phe Phe Ser Ala Pro Glu Gly Tyr Asp His Pro 
            180                 185                 190         


Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg 
        195                 200                 205             


Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Glu Arg Asp Leu Trp 
    210                 215                 220                 


Gln Gln Cys Gly Glu 
225                 


<210>  5945
<211>  1412
<212>  DNA
<213>  Homosapiens

<400>  5945
acgccggcga gcttccgggg cggccccggg caggtcggcg gcggcggccc gcagtcgtgg     60

aggagcggtg ggagcgtcgg cggccgcggg cgatgcaact tccggacggg actcccctct    120

gtccgcgcct cacatctccc cttcctctcg cctagtcctg tgccgttttc cgtccgcgac    180

tcttccggcc cagagctttc ggagtgcggt tgctcagggg aagccgtcgc cgcccccgcc    240

tcggggccga gtgagagtgc ccgtcgcgtc gcgccgcgtc gccccccggg ccgcctcctt    300

gccgccagtg gcgggctccg ttctccctcg aagcactccc cccagctcca tgaatggaaa    360

tcggctccgc aggacccgct ggggcccagc ccctactcat ggtgcccaga agacctggct    420

atggcaccat gggcaaaccc attaaactgc tggctaactg ttttcaagtt gaaatcccaa    480

agattgatgt ctacctctat gaggtagata ttaaaccaga caagtgtcct aggagagtga    540

acagggaggt ggttgactca atggttcagc attttaaagt aactatattt ggagaccgta    600

gaccagttta tgatggaaaa agaagtcttt acaccgccaa tccacttcct gtggcaacta    660

caggggtaga tttagacgtt actttacctg gggaaggtgg aaaagatcga cctttcaagg    720

tgtcaatcaa atttgtctct cgggtgagtt ggcacctact gcatgaagta ctgacaggac    780

ggaccttgcc tgagccactg gaattagaca agccaatcag cactaaccct gtccatgccg    840

ttgatgtggt gctacgacat ctgccctcca tgaaatacac acctgtgggg cgttcatttt    900

tctccgctcc agaaggatat gaccaccctc tgggaggggg cagggaagtg tggtttggat    960

tccatcagtc tgttcggcct gccatgtgga aaatgatgct taatatcgat gaaagagacc   1020

tctggcagca gtgtggagaa tagatagagg agaaaaaact aatctgagaa gccagttagg   1080

aggcttttca atcactagtt caggtttcag tctacatgtt acttccttga gaagcagtgt   1140

ttgacaccct tctcccccaa tccagccatc ccccaagtct gagttaggta tttctcttct   1200

gtattcccat agcacagtgt aattccccta taatagcatg tatcaccttg aattatgggt   1260

gtttattgtt ctgtctctcc tgttagaacg aaagctccat gaagggattg tcattttatt   1320

caccagtgta ccctctatgc ccagcacaac ttttggtcat attaaacaaa gaatgaataa   1380

ataaatccaa gagcatagga ggaggagcat cc                                 1412


<210>  5946
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  5946

Met Glu Ile Gly Ser Ala Gly Pro Ala Gly Ala Gln Pro Leu Leu Met 
1               5                   10                  15      


Val Pro Arg Arg Pro Gly Tyr Gly Thr Met Gly Lys Pro Ile Lys Leu 
            20                  25                  30          


Leu Ala Asn Cys Phe Gln Val Glu Ile Pro Lys Ile Asp Val Tyr Leu 
        35                  40                  45              


Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys Pro Arg Arg Val Asn Arg 
    50                  55                  60                  


Glu Val Val Asp Ser Met Val Gln His Phe Lys Val Thr Ile Phe Gly 
65                  70                  75                  80  


Asp Arg Arg Pro Val Tyr Asp Gly Lys Arg Ser Leu Tyr Thr Ala Asn 
                85                  90                  95      


Pro Leu Pro Val Ala Thr Thr Gly Val Asp Leu Asp Val Thr Leu Pro 
            100                 105                 110         


Gly Glu Gly Gly Lys Asp Arg Pro Phe Lys Val Ser Ile Lys Phe Val 
        115                 120                 125             


Ser Arg Val Ser Trp His Leu Leu His Glu Val Leu Thr Gly Arg Thr 
    130                 135                 140                 


Leu Pro Glu Pro Leu Glu Leu Asp Lys Pro Ile Ser Thr Asn Pro Val 
145                 150                 155                 160 


His Ala Val Asp Val Val Leu Arg His Leu Pro Ser Met Lys Tyr Thr 
                165                 170                 175     


Pro Val Gly Arg Ser Phe Phe Ser Ala Pro Glu Gly Tyr Asp His Pro 
            180                 185                 190         


Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg 
        195                 200                 205             


Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Glu Arg Asp Leu Trp 
    210                 215                 220                 


Gln Gln Cys Gly Glu 
225                 


<210>  5947
<211>  3319
<212>  DNA
<213>  Homosapiens

<400>  5947
acgccggcga gcttccgggg cggccccggg caggtcggcg gcggcggccc gcagtcgtgg     60

aggagcggtg ggagcgtcgg cggccgcggg cgatgcaact tccggacggg actcccctct    120

gtccgcgcct cacatctccc cttcctctcg cctagtcctg tgccgttttc cgtccgcgac    180

tcttccggcc cagagctttc ggagtgcggt tgctcagggg aagccgtcgc cgcccccgcc    240

tcggggccga gtgagagtgc ccgtcgcgtc gcgccgcgtc gccccccggg ccgcctcctt    300

gccgccagtg gcgggctccg ttctccctcg aagcactccc cccagctcca tgaatggaaa    360

tcggctccgc aggacccgct ggggcccagc ccctactcat ggtgcccaga agacctggct    420

atggcaccat gggcaaaccc attaaactgc tggctaactg ttttcaagtt gaaatcccaa    480

agattgatgt ctacctctat gaggtagata ttaaaccaga caagtgtcct aggagagtga    540

acagggaggt ggttgactca atggttcagc attttaaagt aactatattt ggagaccgta    600

gaccagttta tgatggaaaa agaagtcttt acaccgccaa tccacttcct gtggcaacta    660

caggggtaga tttagacgtt actttacctg gggaaggtgg aaaagatcga cctttcaagg    720

tgtcaatcaa atttgtctct cgggtgagtt ggcacctact gcatgaagta ctgacaggac    780

ggaccttgcc tgagccactg gaattagaca agccaatcag cactaaccct gtccatgccg    840

ttgatgtggt gctacgacat ctgccctcca tgaaatacac acctgtgggg cgttcatttt    900

tctccgctcc agaaggatat gaccaccctc tgggaggggg cagggaagtg tggtttggat    960

tccatcagtc tgttcggcct gccatgtgga aaatgatgct taatatcgat gtttctgcca   1020

ctgccttcta caaagcacaa cctgtaattc agttcatgtg tgaagttctt gatattcata   1080

atattgatga gcaaccaaga cctctgactg attctcatcg ggtaaaattc accaaagaga   1140

taaaaggttt gaaggttgaa gtgactcatt gtggaacaat gagacggaaa taccgtgttt   1200

gtaatgtaac aaggaggcct gccagtcatc aaacctttcc tttacagtta gaaaacggcc   1260

aaactgtgga gagaacagta gcgcagtatt tcagagaaaa gtatactctt cagctgaagt   1320

acccgcacct tccctgtctg caagtcgggc aggaacagaa acacacctac ctgccactag   1380

aagtctgtaa tattgtggca gggcaacgat gtatcaagaa gctaacagac aatcagactt   1440

ccactatgat caaggcaaca gcaagatctg caccagatag acaagaggaa attagcagat   1500

tggtaagaag tgcaaattat gaaacagatc catttgttca ggagtttcaa tttaaagttc   1560

gggatgaaat ggctcatgta actggacgcg tacttccagc acctatgctc cagtatggag   1620

gacggaatcg gacagtagca acaccgagcc atggagtatg ggacatgcga gggaaacaat   1680

tccacacagg agttgaaatc aaaatgtggg ctatcgcttg ttttgccaca cagaggcagt   1740

gcagagaaga aatattgaag ggtttcacag accagctgcg taagatttct aaggatgcag   1800

ggatgcccat ccagggccag ccatgcttct gcaaatatgc acagggggca gacagcgtag   1860

agcccatgtt ccggcatctc aagaacacat attctggcct acagcttatt atcgtcatcc   1920

tgccggggaa gacaccagtg tatgcggaag tgaaacgtgt aggagacaca cttttgggta   1980

tggctacaca atgtgttcaa gtcaagaatg taataaaaac atctcctcaa actctgtcaa   2040

acttgtgcct aaagataaat gttaaactcg gagggatcaa taatattctt gtacctcatc   2100

aaagaccttc tgtgttccag caaccagtga tctttttggg agccgatgtc actcatccac   2160

ctgctggtga tggaaagaag ccttctattg ctgctgttgt aggtagtatg gatgcacacc   2220

caagcagata ctgtgccaca gtaagagttc agagaccccg acaggagatc atccaggact   2280

tggcctccat ggtccgggaa cttcttattc aattttataa gtcaactcgg ttcaagccta   2340

ctcgtatcat cttttatcgg gatggtgttt cagaggggca gtttaggcag gtattatatt   2400

atgaactact agcaattcga gaagcctgca tcagtttgga gaaagactat caacctggaa   2460

taacctacat tgtagttcag aagagacatc acactcgatt attttgtgct gataggacag   2520

aaagggttgg aagaagtggc aatatcccag ctggaacaac agttgataca gacattacac   2580

acccatatga gttcgatttt tacctctgta gccatgctgg aatacagggt accagtcgtc   2640

cttcacacta tcatgtttta tgggatgata actgctttac tgcagatgaa cttcagctgc   2700

taacttacca gctctgccac acttacgtac gctgtacacg atctgtttct atacctgcac   2760

cagcgtatta tgctcacctg gtagcattta gagccagata tcatcttgtg gacaaagaac   2820

atgacagtgc tgaaggaagt cacgtttcag gacaaagcaa tgggcgagat ccacaagctc   2880

ttgccaaggc tgtacagatt caccaagata ccttacgcac aatgtacttc gcttaaatag   2940

tccaagtata ttctctgaga ggaagtactg aaagatgaat tgacatacaa cgtatgtttc   3000

cagtgaagtc aattgagtaa ggacacctcc agccatacag aaaccaacac tgtgtggggg   3060

ccaaggtctg atccttatgt taatacaagg aagattgttt acttcatcaa ggaacacagc   3120

atcattatgc aatatgaaac cagccaactg ctttttgtgc ggtctcctat aggaagtatc   3180

gcaattgttt tgttttcatt tcttgtagtc taaccctttt aatgccttta cctcaagttg   3240

cttggcagca caactatctt tgcaaaaaaa agtaaagaaa aagtaaatga tggtttaaaa   3300

aatacacacc ttcatgaat                                                3319


<210>  5948
<211>  860
<212>  PRT
<213>  Homosapiens

<400>  5948

Met Glu Ile Gly Ser Ala Gly Pro Ala Gly Ala Gln Pro Leu Leu Met 
1               5                   10                  15      


Val Pro Arg Arg Pro Gly Tyr Gly Thr Met Gly Lys Pro Ile Lys Leu 
            20                  25                  30          


Leu Ala Asn Cys Phe Gln Val Glu Ile Pro Lys Ile Asp Val Tyr Leu 
        35                  40                  45              


Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys Pro Arg Arg Val Asn Arg 
    50                  55                  60                  


Glu Val Val Asp Ser Met Val Gln His Phe Lys Val Thr Ile Phe Gly 
65                  70                  75                  80  


Asp Arg Arg Pro Val Tyr Asp Gly Lys Arg Ser Leu Tyr Thr Ala Asn 
                85                  90                  95      


Pro Leu Pro Val Ala Thr Thr Gly Val Asp Leu Asp Val Thr Leu Pro 
            100                 105                 110         


Gly Glu Gly Gly Lys Asp Arg Pro Phe Lys Val Ser Ile Lys Phe Val 
        115                 120                 125             


Ser Arg Val Ser Trp His Leu Leu His Glu Val Leu Thr Gly Arg Thr 
    130                 135                 140                 


Leu Pro Glu Pro Leu Glu Leu Asp Lys Pro Ile Ser Thr Asn Pro Val 
145                 150                 155                 160 


His Ala Val Asp Val Val Leu Arg His Leu Pro Ser Met Lys Tyr Thr 
                165                 170                 175     


Pro Val Gly Arg Ser Phe Phe Ser Ala Pro Glu Gly Tyr Asp His Pro 
            180                 185                 190         


Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg 
        195                 200                 205             


Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Thr Ala 
    210                 215                 220                 


Phe Tyr Lys Ala Gln Pro Val Ile Gln Phe Met Cys Glu Val Leu Asp 
225                 230                 235                 240 


Ile His Asn Ile Asp Glu Gln Pro Arg Pro Leu Thr Asp Ser His Arg 
                245                 250                 255     


Val Lys Phe Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Val Thr His 
            260                 265                 270         


Cys Gly Thr Met Arg Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg 
        275                 280                 285             


Pro Ala Ser His Gln Thr Phe Pro Leu Gln Leu Glu Asn Gly Gln Thr 
    290                 295                 300                 


Val Glu Arg Thr Val Ala Gln Tyr Phe Arg Glu Lys Tyr Thr Leu Gln 
305                 310                 315                 320 


Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys 
                325                 330                 335     


His Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg 
            340                 345                 350         


Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile Lys Ala 
        355                 360                 365             


Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg Leu Val 
    370                 375                 380                 


Arg Ser Ala Asn Tyr Glu Thr Asp Pro Phe Val Gln Glu Phe Gln Phe 
385                 390                 395                 400 


Lys Val Arg Asp Glu Met Ala His Val Thr Gly Arg Val Leu Pro Ala 
                405                 410                 415     


Pro Met Leu Gln Tyr Gly Gly Arg Asn Arg Thr Val Ala Thr Pro Ser 
            420                 425                 430         


His Gly Val Trp Asp Met Arg Gly Lys Gln Phe His Thr Gly Val Glu 
        435                 440                 445             


Ile Lys Met Trp Ala Ile Ala Cys Phe Ala Thr Gln Arg Gln Cys Arg 
    450                 455                 460                 


Glu Glu Ile Leu Lys Gly Phe Thr Asp Gln Leu Arg Lys Ile Ser Lys 
465                 470                 475                 480 


Asp Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala 
                485                 490                 495     


Gln Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Thr 
            500                 505                 510         


Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys Thr Pro 
        515                 520                 525             


Val Tyr Ala Glu Val Lys Arg Val Gly Asp Thr Leu Leu Gly Met Ala 
    530                 535                 540                 


Thr Gln Cys Val Gln Val Lys Asn Val Ile Lys Thr Ser Pro Gln Thr 
545                 550                 555                 560 


Leu Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Ile Asn 
                565                 570                 575     


Asn Ile Leu Val Pro His Gln Arg Pro Ser Val Phe Gln Gln Pro Val 
            580                 585                 590         


Ile Phe Leu Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp Gly Lys 
        595                 600                 605             


Lys Pro Ser Ile Ala Ala Val Val Gly Ser Met Asp Ala His Pro Ser 
    610                 615                 620                 


Arg Tyr Cys Ala Thr Val Arg Val Gln Arg Pro Arg Gln Glu Ile Ile 
625                 630                 635                 640 


Gln Asp Leu Ala Ser Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys 
                645                 650                 655     


Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp Gly Val 
            660                 665                 670         


Ser Glu Gly Gln Phe Arg Gln Val Leu Tyr Tyr Glu Leu Leu Ala Ile 
        675                 680                 685             


Arg Glu Ala Cys Ile Ser Leu Glu Lys Asp Tyr Gln Pro Gly Ile Thr 
    690                 695                 700                 


Tyr Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys Ala Asp 
705                 710                 715                 720 


Arg Thr Glu Arg Val Gly Arg Ser Gly Asn Ile Pro Ala Gly Thr Thr 
                725                 730                 735     


Val Asp Thr Asp Ile Thr His Pro Tyr Glu Phe Asp Phe Tyr Leu Cys 
            740                 745                 750         


Ser His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr His Val 
        755                 760                 765             


Leu Trp Asp Asp Asn Cys Phe Thr Ala Asp Glu Leu Gln Leu Leu Thr 
    770                 775                 780                 


Tyr Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile 
785                 790                 795                 800 


Pro Ala Pro Ala Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr 
                805                 810                 815     


His Leu Val Asp Lys Glu His Asp Ser Ala Glu Gly Ser His Val Ser 
            820                 825                 830         


Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val Gln 
        835                 840                 845             


Ile His Gln Asp Thr Leu Arg Thr Met Tyr Phe Ala 
    850                 855                 860 


<210>  5949
<211>  3652
<212>  DNA
<213>  Homosapiens

<400>  5949
acgccggcga gcttccgggg cggccccggg caggtcggcg gcggcggccc gcagtcgtgg     60

aggagcggtg ggagcgtcgg cggccgcggg cgatgcaact tccggacggg actcccctct    120

gtccgcgcct cacatctccc cttcctctcg cctagtcctg tgccgttttc cgtccgcgac    180

tcttccggcc cagagctttc ggagtgcggt tgctcagggg aagccgtcgc cgcccccgcc    240

tcggggccga gtgagagtgc ccgtcgcgtc gcgccgcgtc gccccccggg ccgcctcctt    300

gccgccagtg gcgggctccg ttctccctcg aagcactccc cccagctcca tgaatggaaa    360

tcggctccgc aggacccgct ggggcccagc ccctactcat ggtgcccaga agacctggct    420

atggcaccat gggcaaaccc attaaactgc tggctaactg ttttcaagtt gaaatcccaa    480

agattgatgt ctacctctat gaggtagata ttaaaccaga caagtgtcct aggagagtga    540

acagggaggt ggttgactca atggttcagc attttaaagt aactatattt ggagaccgta    600

gaccagttta tgatggaaaa agaagtcttt acaccgccaa tccacttcct gtggcaacta    660

caggggtaga tttagacgtt actttacctg gggaaggtgg aaaagatcga cctttcaagg    720

tgtcaatcaa atttgtctct cgggtgagtt ggcacctact gcatgaagta ctgacaggac    780

ggaccttgcc tgagccactg gaattagaca agccaatcag cactaaccct gtccatgccg    840

ttgatgtggt gctacgacat ctgccctcca tgaaatacac acctgtgggg cgttcatttt    900

tctccgctcc agaaggatat gaccaccctc tgggaggggg cagggaagtg tggtttggat    960

tccatcagtc tgttcggcct gccatgtgga aaatgatgct taatatcgat gtttctgcca   1020

ctgccttcta caaagcacaa cctgtaattc agttcatgtg tgaagttctt gatattcata   1080

atattgatga gcaaccaaga cctctgactg attctcatcg ggtaaaattc accaaagaga   1140

taaaaggttt gaaggttgaa gtgactcatt gtggaacaat gagacggaaa taccgtgttt   1200

gtaatgtaac aaggaggcct gccagtcatc aaacctttcc tttacagtta gaaaacggcc   1260

aaactgtgga gagaacagta gcgcagtatt tcagagaaaa gtatactctt cagctgaagt   1320

acccgcacct tccctgtctg caagtcgggc aggaacagaa acacacctac ctgccactag   1380

aagtctgtaa tattgtggca gggcaacgat gtatcaagaa gctaacagac aatcagactt   1440

ccactatgat caaggcaaca gcaagatctg caccagatag acaagaggaa attagcagat   1500

tggtaagaag tgcaaattat gaaacagatc catttgttca ggagtttcaa tttaaagttc   1560

gggatgaaat ggctcatgta actggacgcg tacttccagc acctatgctc cagtatggag   1620

gacggaatcg gacagtagca acaccgagcc atggagtatg ggacatgcga gggaaacaat   1680

tccacacagg agttgaaatc aaaatgtggg ctatcgcttg ttttgccaca cagaggcagt   1740

gcagagaaga aatattgaag ggtttcacag accagctgcg taagatttct aaggatgcag   1800

ggatgcccat ccagggccag ccatgcttct gcaaatatgc acagggggca gacagcgtag   1860

agcccatgtt ccggcatctc aagaacacat attctggcct acagcttatt atcgtcatcc   1920

tgccggggaa gacaccagtg tatgcggaag tgaaacgtgt aggagacaca cttttgggta   1980

tggctacaca atgtgttcaa gtcaagaatg taataaaaac atctcctcaa actctgtcaa   2040

acttgtgcct aaagataaat gttaaactcg gagggatcaa taatattctt gtacctcatc   2100

aaagaccttc tgtgttccag caaccagtga tctttttggg agccgatgtc actcatccac   2160

ctgctggtga tggaaagaag ccttctattg ctgctgttgt aggtagtatg gatgcacacc   2220

caagcagata ctgtgccaca gtaagagttc agagaccccg acaggagatc atccaggact   2280

tggcctccat ggtccgggaa cttcttattc aattttataa gtcaactcgg ttcaagccta   2340

ctcgtatcat cttttatcgg gatggtgttt cagaggggca gtttaggcag gtattatatt   2400

atgaactact agcaattcga gaagcctgca tcagtttgga gaaagactat caacctggaa   2460

taacctacat tgtagttcag aagagacatc acactcgatt attttgtgct gataggacag   2520

aaagggttgg aagaagtggc aatatcccag ctggaacaac agttgataca gacattacac   2580

acccatatga gttcgatttt tacctctgta gccatgctgg aatacagggt accagtcgtc   2640

cttcacacta tcatgtttta tgggatgata actgctttac tgcagatgaa cttcagctgc   2700

taacttacca gctctgccac acttacgtac gctgtacacg atctgtttct atacctgcac   2760

cagcgtatta tgctcacctg gtagcattta gagccagata tcatcttgtg gacaaagaac   2820

atgacagtgc tgaaggaagt cacgtttcag gacaaagcaa tgggcgagat ccacaagctc   2880

ttgccaaggc tgtacagatt caccaagata ccttacgcac aatgtacttc gcttaaatag   2940

tccaagtata ttctctgaga ggaagtactg aaagatgaat tgacatacaa cgtatgtttc   3000

cagtgaagtc aattgagtaa ggacacctcc agccatacag aaaccaacac tgtgtggggg   3060

ccaaggtctg atccttatgt taatacaagg aagattgttt acttcatcaa ggaacacagc   3120

atcattatgc aatatgaaac cagccaactg ctttttgtgc ggtctcctat aggaagtatc   3180

gcaattgttt tgttttcatt tcttgtagtc taaccctttt aatgccttta cctcaagttg   3240

cttggcagca caactatctt tgcaaaaaaa agtaaagaaa aagtaaatga tggtttaaaa   3300

aatacacacc ttcatgaata atcaaagtga tttttcagaa ttatgtgtgc aaaaaattaa   3360

tgtgcattca tatattcttg taaaaggtgt ctgtgtattt ttaaaatata tacatccata   3420

cttcatatgc atatatatct agatctggat tgataataga tatatatgtg tctgttatat   3480

attttagagt tcattccatt ggggaatttt ctttcccttt tattctaccc ccactaccgc   3540

ctttatttct ctatttccct tgccttcatc acctacattt ttttcccagt cctaccagtg   3600

acattcaaat gttgatgtat ctggttcgtt tgaatataaa atatggcaaa ct           3652


<210>  5950
<211>  860
<212>  PRT
<213>  Homosapiens

<400>  5950

Met Glu Ile Gly Ser Ala Gly Pro Ala Gly Ala Gln Pro Leu Leu Met 
1               5                   10                  15      


Val Pro Arg Arg Pro Gly Tyr Gly Thr Met Gly Lys Pro Ile Lys Leu 
            20                  25                  30          


Leu Ala Asn Cys Phe Gln Val Glu Ile Pro Lys Ile Asp Val Tyr Leu 
        35                  40                  45              


Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys Pro Arg Arg Val Asn Arg 
    50                  55                  60                  


Glu Val Val Asp Ser Met Val Gln His Phe Lys Val Thr Ile Phe Gly 
65                  70                  75                  80  


Asp Arg Arg Pro Val Tyr Asp Gly Lys Arg Ser Leu Tyr Thr Ala Asn 
                85                  90                  95      


Pro Leu Pro Val Ala Thr Thr Gly Val Asp Leu Asp Val Thr Leu Pro 
            100                 105                 110         


Gly Glu Gly Gly Lys Asp Arg Pro Phe Lys Val Ser Ile Lys Phe Val 
        115                 120                 125             


Ser Arg Val Ser Trp His Leu Leu His Glu Val Leu Thr Gly Arg Thr 
    130                 135                 140                 


Leu Pro Glu Pro Leu Glu Leu Asp Lys Pro Ile Ser Thr Asn Pro Val 
145                 150                 155                 160 


His Ala Val Asp Val Val Leu Arg His Leu Pro Ser Met Lys Tyr Thr 
                165                 170                 175     


Pro Val Gly Arg Ser Phe Phe Ser Ala Pro Glu Gly Tyr Asp His Pro 
            180                 185                 190         


Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg 
        195                 200                 205             


Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Thr Ala 
    210                 215                 220                 


Phe Tyr Lys Ala Gln Pro Val Ile Gln Phe Met Cys Glu Val Leu Asp 
225                 230                 235                 240 


Ile His Asn Ile Asp Glu Gln Pro Arg Pro Leu Thr Asp Ser His Arg 
                245                 250                 255     


Val Lys Phe Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Val Thr His 
            260                 265                 270         


Cys Gly Thr Met Arg Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg 
        275                 280                 285             


Pro Ala Ser His Gln Thr Phe Pro Leu Gln Leu Glu Asn Gly Gln Thr 
    290                 295                 300                 


Val Glu Arg Thr Val Ala Gln Tyr Phe Arg Glu Lys Tyr Thr Leu Gln 
305                 310                 315                 320 


Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys 
                325                 330                 335     


His Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg 
            340                 345                 350         


Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile Lys Ala 
        355                 360                 365             


Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg Leu Val 
    370                 375                 380                 


Arg Ser Ala Asn Tyr Glu Thr Asp Pro Phe Val Gln Glu Phe Gln Phe 
385                 390                 395                 400 


Lys Val Arg Asp Glu Met Ala His Val Thr Gly Arg Val Leu Pro Ala 
                405                 410                 415     


Pro Met Leu Gln Tyr Gly Gly Arg Asn Arg Thr Val Ala Thr Pro Ser 
            420                 425                 430         


His Gly Val Trp Asp Met Arg Gly Lys Gln Phe His Thr Gly Val Glu 
        435                 440                 445             


Ile Lys Met Trp Ala Ile Ala Cys Phe Ala Thr Gln Arg Gln Cys Arg 
    450                 455                 460                 


Glu Glu Ile Leu Lys Gly Phe Thr Asp Gln Leu Arg Lys Ile Ser Lys 
465                 470                 475                 480 


Asp Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala 
                485                 490                 495     


Gln Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Thr 
            500                 505                 510         


Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys Thr Pro 
        515                 520                 525             


Val Tyr Ala Glu Val Lys Arg Val Gly Asp Thr Leu Leu Gly Met Ala 
    530                 535                 540                 


Thr Gln Cys Val Gln Val Lys Asn Val Ile Lys Thr Ser Pro Gln Thr 
545                 550                 555                 560 


Leu Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Ile Asn 
                565                 570                 575     


Asn Ile Leu Val Pro His Gln Arg Pro Ser Val Phe Gln Gln Pro Val 
            580                 585                 590         


Ile Phe Leu Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp Gly Lys 
        595                 600                 605             


Lys Pro Ser Ile Ala Ala Val Val Gly Ser Met Asp Ala His Pro Ser 
    610                 615                 620                 


Arg Tyr Cys Ala Thr Val Arg Val Gln Arg Pro Arg Gln Glu Ile Ile 
625                 630                 635                 640 


Gln Asp Leu Ala Ser Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys 
                645                 650                 655     


Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp Gly Val 
            660                 665                 670         


Ser Glu Gly Gln Phe Arg Gln Val Leu Tyr Tyr Glu Leu Leu Ala Ile 
        675                 680                 685             


Arg Glu Ala Cys Ile Ser Leu Glu Lys Asp Tyr Gln Pro Gly Ile Thr 
    690                 695                 700                 


Tyr Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys Ala Asp 
705                 710                 715                 720 


Arg Thr Glu Arg Val Gly Arg Ser Gly Asn Ile Pro Ala Gly Thr Thr 
                725                 730                 735     


Val Asp Thr Asp Ile Thr His Pro Tyr Glu Phe Asp Phe Tyr Leu Cys 
            740                 745                 750         


Ser His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr His Val 
        755                 760                 765             


Leu Trp Asp Asp Asn Cys Phe Thr Ala Asp Glu Leu Gln Leu Leu Thr 
    770                 775                 780                 


Tyr Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile 
785                 790                 795                 800 


Pro Ala Pro Ala Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr 
                805                 810                 815     


His Leu Val Asp Lys Glu His Asp Ser Ala Glu Gly Ser His Val Ser 
            820                 825                 830         


Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val Gln 
        835                 840                 845             


Ile His Gln Asp Thr Leu Arg Thr Met Tyr Phe Ala 
    850                 855                 860 


<210>  5951
<211>  3026
<212>  DNA
<213>  Homosapiens

<400>  5951
acttccggac gggactcccc tctgtccgcg cctcacatct ccccttcctc tcgcctagtc     60

ctgtgccgtt ttccgtccgc gactcttccg gcccagagct ttcggagtgc ggttgctcag    120

gggaagccgt cgccgccccc gcctcggggc cgagtgagag tgcccgtcgc gtcgcgccgc    180

gtcgcccccc gggccgcctc cttgccgcca gtggcgggct ccgttctccc tcgaagcact    240

ccccccagct ccatgaatgg aaatcggctc cgcaggaccc gctggggccc agcccctact    300

catggtgccc agaagacctg gctatggcac catgggcaaa cccattaaac tgctggctaa    360

ctgttttcaa gttgaaatcc caaagattga tgtctacctc tatgaggtag atattaaacc    420

agacaagtgt cctaggagag tgaacaggta gatttagacg ttactttacc tggggaaggt    480

ggaaaagatc gacctttcaa ggtgtcaatc aaatttgtct ctcgggtgag ttggcaccta    540

ctgcatgaag tactgacagg acggaccttg cctgagccac tggaattaga caagccaatc    600

agcactaacc ctgtccatgc cgttgatgtg gtgctacgac atctgccctc catgaatttc    660

tgccactgcc ttctacaaag cacaacctgt aattcagttc atgtgtgaag ttcttgatat    720

tcataatatt gatgagcaac caagacctct gactgattct catcgggtaa aattcaccaa    780

agagataaaa ggtttgaagg ttgaagtgac tcattgtgga acaatgagac ggaaataccg    840

tgtttgtaat gtaacaagga ggcctgccag tcatcaaacc tttcctttac agttagaaaa    900

cggccaaact gtggagagaa cagtagcgca gtatttcaga gaaaagtata ctcttcagct    960

gaagtacccg caccttccct gtctgcaagt cgggcaggaa cagaaacaca cctacctgcc   1020

actagaagtc tgtaatattg tggcagggca acgatgtatc aagaagctaa cagacaatca   1080

gacttccact atgatcaagg caacagcaag atctgcacca gatagacaag aggaaattag   1140

cagattggta agaagtgcaa attatgaaac agatccattt gttcaggagt ttcaatttaa   1200

agttcgggat gaaatggctc atgtaactgg acgcgtactt ccagcaccta tgctccagta   1260

tggaggacgg aatcggacag tagcaacacc gagccatgga gtatgggaca tgcgagggaa   1320

acaattccac acaggagttg aaatcaaaat gtgggctatc gcttgttttg ccacacagag   1380

gcagtgcaga gaagaaatat tgaagggttt cacagaccag ctgcgtaaga tttctaagga   1440

tgcagggatg cccatccagg gccagccatg cttctgcaaa tatgcacagg gggcagacag   1500

cgtagagccc atgttccggc atctcaagaa cacatattct ggcctacagc ttattatcgt   1560

catcctgccg gggaagacac cagtgtatgc ggaagtgaaa cgtgtaggag acacactttt   1620

gggtatggct acacaatgtg ttcaagtcaa gaatgtaata aaaacatctc ctcaaactct   1680

gtcaaacttg tgcctaaaga taaatgttaa actcggaggg atcaataata ttcttgtacc   1740

tcatcaaaga ccttctgtgt tccagcaacc agtgatcttt ttgggagccg atgtcactca   1800

tccacctgct ggtgatggaa agaagccttc tattgctgct gttgtaggta gtatggatgc   1860

acacccaagc agatactgtg ccacagtaag agttcagaga ccccgacagg agatcatcca   1920

ggacttggcc tccatggtcc gggaacttct tattcaattt tataagtcaa ctcggttcaa   1980

gcctactcgt atcatctttt atcgggatgg tgtttcagag gggcagttta ggcaggtatt   2040

atattatgaa ctactagcaa ttcgagaagc ctgcatcagt ttggagaaag actatcaacc   2100

tggaataacc tacattgtag ttcagaagag acatcacact cgattatttt gtgctgatag   2160

gacagaaagg gttggaagaa gtggcaatat cccagctgga acaacagttg atacagacat   2220

tacacaccca tatgagttcg atttttacct ctgtagccat gctggaatac agggtaccag   2280

tcgtccttca cactatcatg ttttatggga tgataactgc tttactgcag atgaacttca   2340

gctgctaact taccagctct gccacactta cgtacgctgt acacgatctg tttctatacc   2400

tgcaccagcg tattatgctc acctggtagc atttagagcc agatatcatc ttgtggacaa   2460

agaacatgac agtgctgaag gaagtcacgt ttcaggacaa agcaatgggc gagatccaca   2520

agctcttgcc aaggctgtac agattcacca agatacctta cgcacaatgt acttcgctta   2580

aatagtccaa gtatattctc tgagaggaag tactgaaaga tgaattgaca tacaacgtat   2640

gtttccagtg aagtcaattg agtaaggaca cctccagcca tacagaaacc aacactgtgt   2700

gggggccaag gtctgatcct tatgttaata caaggaagat tgtttacttc atcaaggaac   2760

acagcatcat tatgcaatat gaaaccagcc aactgctttt tgtgcggtct cctataggaa   2820

gtatcgcaat tgttttgttt tcatttcttg tagtctaacc cttttaatgc ctttacctca   2880

agttgcttgg cagcacaact atctttgcaa aaaaaagtaa agaaaaagta aatgatggtt   2940

taaaaaatac acaccttcat gaataatcaa agtgattttt cagaattatg tgtgcaaaaa   3000

attaatgtgc attcatatat tcttgt                                        3026


<210>  5952
<211>  626
<212>  PRT
<213>  Homosapiens

<400>  5952

Met Cys Glu Val Leu Asp Ile His Asn Ile Asp Glu Gln Pro Arg Pro 
1               5                   10                  15      


Leu Thr Asp Ser His Arg Val Lys Phe Thr Lys Glu Ile Lys Gly Leu 
            20                  25                  30          


Lys Val Glu Val Thr His Cys Gly Thr Met Arg Arg Lys Tyr Arg Val 
        35                  40                  45              


Cys Asn Val Thr Arg Arg Pro Ala Ser His Gln Thr Phe Pro Leu Gln 
    50                  55                  60                  


Leu Glu Asn Gly Gln Thr Val Glu Arg Thr Val Ala Gln Tyr Phe Arg 
65                  70                  75                  80  


Glu Lys Tyr Thr Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln 
                85                  90                  95      


Val Gly Gln Glu Gln Lys His Thr Tyr Leu Pro Leu Glu Val Cys Asn 
            100                 105                 110         


Ile Val Ala Gly Gln Arg Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr 
        115                 120                 125             


Ser Thr Met Ile Lys Ala Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu 
    130                 135                 140                 


Glu Ile Ser Arg Leu Val Arg Ser Ala Asn Tyr Glu Thr Asp Pro Phe 
145                 150                 155                 160 


Val Gln Glu Phe Gln Phe Lys Val Arg Asp Glu Met Ala His Val Thr 
                165                 170                 175     


Gly Arg Val Leu Pro Ala Pro Met Leu Gln Tyr Gly Gly Arg Asn Arg 
            180                 185                 190         


Thr Val Ala Thr Pro Ser His Gly Val Trp Asp Met Arg Gly Lys Gln 
        195                 200                 205             


Phe His Thr Gly Val Glu Ile Lys Met Trp Ala Ile Ala Cys Phe Ala 
    210                 215                 220                 


Thr Gln Arg Gln Cys Arg Glu Glu Ile Leu Lys Gly Phe Thr Asp Gln 
225                 230                 235                 240 


Leu Arg Lys Ile Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln Pro 
                245                 250                 255     


Cys Phe Cys Lys Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met Phe 
            260                 265                 270         


Arg His Leu Lys Asn Thr Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile 
        275                 280                 285             


Leu Pro Gly Lys Thr Pro Val Tyr Ala Glu Val Lys Arg Val Gly Asp 
    290                 295                 300                 


Thr Leu Leu Gly Met Ala Thr Gln Cys Val Gln Val Lys Asn Val Ile 
305                 310                 315                 320 


Lys Thr Ser Pro Gln Thr Leu Ser Asn Leu Cys Leu Lys Ile Asn Val 
                325                 330                 335     


Lys Leu Gly Gly Ile Asn Asn Ile Leu Val Pro His Gln Arg Pro Ser 
            340                 345                 350         


Val Phe Gln Gln Pro Val Ile Phe Leu Gly Ala Asp Val Thr His Pro 
        355                 360                 365             


Pro Ala Gly Asp Gly Lys Lys Pro Ser Ile Ala Ala Val Val Gly Ser 
    370                 375                 380                 


Met Asp Ala His Pro Ser Arg Tyr Cys Ala Thr Val Arg Val Gln Arg 
385                 390                 395                 400 


Pro Arg Gln Glu Ile Ile Gln Asp Leu Ala Ser Met Val Arg Glu Leu 
                405                 410                 415     


Leu Ile Gln Phe Tyr Lys Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile 
            420                 425                 430         


Phe Tyr Arg Asp Gly Val Ser Glu Gly Gln Phe Arg Gln Val Leu Tyr 
        435                 440                 445             


Tyr Glu Leu Leu Ala Ile Arg Glu Ala Cys Ile Ser Leu Glu Lys Asp 
    450                 455                 460                 


Tyr Gln Pro Gly Ile Thr Tyr Ile Val Val Gln Lys Arg His His Thr 
465                 470                 475                 480 


Arg Leu Phe Cys Ala Asp Arg Thr Glu Arg Val Gly Arg Ser Gly Asn 
                485                 490                 495     


Ile Pro Ala Gly Thr Thr Val Asp Thr Asp Ile Thr His Pro Tyr Glu 
            500                 505                 510         


Phe Asp Phe Tyr Leu Cys Ser His Ala Gly Ile Gln Gly Thr Ser Arg 
        515                 520                 525             


Pro Ser His Tyr His Val Leu Trp Asp Asp Asn Cys Phe Thr Ala Asp 
    530                 535                 540                 


Glu Leu Gln Leu Leu Thr Tyr Gln Leu Cys His Thr Tyr Val Arg Cys 
545                 550                 555                 560 


Thr Arg Ser Val Ser Ile Pro Ala Pro Ala Tyr Tyr Ala His Leu Val 
                565                 570                 575     


Ala Phe Arg Ala Arg Tyr His Leu Val Asp Lys Glu His Asp Ser Ala 
            580                 585                 590         


Glu Gly Ser His Val Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala 
        595                 600                 605             


Leu Ala Lys Ala Val Gln Ile His Gln Asp Thr Leu Arg Thr Met Tyr 
    610                 615                 620                 


Phe Ala 
625     


<210>  5953
<211>  3297
<212>  DNA
<213>  Homosapiens

<400>  5953
acttccggac gggactcccc tctgtccgcg cctcacatct ccccttcctc tcgcctagtc     60

ctgtgccgtt ttccgtccgc gactcttccg gcccagagct ttcggagtgc ggttgctcag    120

gggaagccgt cgccgccccc gcctcggggc cgagtgagag tgcccgtcgc gtcgcgccgc    180

gtcgcccccc gggccgcctc cttgccgcca gtggcgggct ccgttctccc tcgaagcact    240

ccccccagct ccatgaatgg aaatcggctc cgcaggaccc gctggggccc agcccctact    300

catggtgccc agaagacctg gctatggcac catgggcaaa cccattaaac tgctggctaa    360

ctgttttcaa gttgaaatcc caaagattga tgtctacctc tatgaggtag atattaaacc    420

agacaagtgt cctaggagag tgaacaggta gatttagacg ttactttacc tggggaaggt    480

ggaaaagatc gacctttcaa ggtgtcaatc aaatttgtct ctcgggtgag ttggcaccta    540

ctgcatgaag tactgacagg acggaccttg cctgagccac tggaattaga caagccaatc    600

agcactaacc ctgtccatgc cgttgatgtg gtgctacgac atctgccctc catgaatttc    660

tgccactgcc ttctacaaag cacaacctgt aattcagttc atgtgtgaag ttcttgatat    720

tcataatatt gatgagcaac caagacctct gactgattct catcgggtaa aattcaccaa    780

agagataaaa ggtttgaagg ttgaagtgac tcattgtgga acaatgagac ggaaataccg    840

tgtttgtaat gtaacaagga ggcctgccag tcatcaaacc tttcctttac agttagaaaa    900

cggccaaact gtggagagaa cagtagcgca gtatttcaga gaaaagtata ctcttcagct    960

gaagtacccg caccttccct gtctgcaagt cgggcaggaa cagaaacaca cctacctgcc   1020

actagaagtc tgtaatattg tggcagggca acgatgtatc aagaagctaa cagacaatca   1080

gacttccact atgatcaagg caacagcaag atctgcacca gatagacaag aggaaattag   1140

cagattggta agaagtgcaa attatgaaac agatccattt gttcaggagt ttcaatttaa   1200

agttcgggat gaaatggctc atgtaactgg acgcgtactt ccagcaccta tgctccagta   1260

tggaggacgg aatcggacag tagcaacacc gagccatgga gtatgggaca tgcgagggaa   1320

acaattccac acaggagttg aaatcaaaat gtgggctatc gcttgttttg ccacacagag   1380

gcagtgcaga gaagaaatat tgaagggttt cacagaccag ctgcgtaaga tttctaagga   1440

tgcagggatg cccatccagg gccagccatg cttctgcaaa tatgcacagg gggcagacag   1500

cgtagagccc atgttccggc atctcaagaa cacatattct ggcctacagc ttattatcgt   1560

catcctgccg gggaagacac cagtgtatgc ggaagtgaaa cgtgtaggag acacactttt   1620

gggtatggct acacaatgtg ttcaagtcaa gaatgtaata aaaacatctc ctcaaactct   1680

gtcaaacttg tgcctaaaga taaatgttaa actcggaggg atcaataata ttcttgtacc   1740

tcatcaaaga ccttctgtgt tccagcaacc agtgatcttt ttgggagccg atgtcactca   1800

tccacctgct ggtgatggaa agaagccttc tattgctgct gttgtaggta gtatggatgc   1860

acacccaagc agatactgtg ccacagtaag agttcagaga ccccgacagg agatcatcca   1920

ggacttggcc tccatggtcc gggaacttct tattcaattt tataagtcaa ctcggttcaa   1980

gcctactcgt atcatctttt atcgggatgg tgtttcagag gggcagttta ggcaggtatt   2040

atattatgaa ctactagcaa ttcgagaagc ctgcatcagt ttggagaaag actatcaacc   2100

tggaataacc tacattgtag ttcagaagag acatcacact cgattatttt gtgctgatag   2160

gacagaaagg gttggaagaa gtggcaatat cccagctgga acaacagttg atacagacat   2220

tacacaccca tatgagttcg atttttacct ctgtagccat gctggaatac agggtaccag   2280

tcgtccttca cactatcatg ttttatggga tgataactgc tttactgcag atgaacttca   2340

gctgctaact taccagctct gccacactta cgtacgctgt acacgatctg tttctatacc   2400

tgcaccagcg tattatgctc acctggtagc atttagagcc agatatcatc ttgtggacaa   2460

agaacatgac agtgctgaag gaagtcacgt ttcaggacaa agcaatgggc gagatccaca   2520

agctcttgcc aaggctgtac agattcacca agatacctta cgcacaatgt acttcgctta   2580

aatagtccaa gtatattctc tgagaggaag tactgaaaga tgaattgaca tacaacgtat   2640

gtttccagtg aagtcaattg agtaaggaca cctccagcca tacagaaacc aacactgtgt   2700

gggggccaag gtctgatcct tatgttaata caaggaagat tgtttacttc atcaaggaac   2760

acagcatcat tatgcaatat gaaaccagcc aactgctttt tgtgcggtct cctataggaa   2820

gtatcgcaat tgttttgttt tcatttcttg tagtctaacc cttttaatgc ctttacctca   2880

agttgcttgg cagcacaact atctttgcaa aaaaaagtaa agaaaaagta aatgatggtt   2940

taaaaaatac acaccttcat gaataatcaa agtgattttt cagaattatg tgtgcaaaaa   3000

attaatgtgc attcatatat tcttgtaaaa ggtgtctgtg tatttttaaa atatatacat   3060

ccatacttca tatgcatata tatctagatc tggattgata atagatatat atgtgtctgt   3120

tatatatttt agagttcatt ccattgggga attttctttc ccttttattc tacccccact   3180

accgccttta tttctctatt tcccttgcct tcatcaccta catttttttc ccagtcctac   3240

cagtgacatt caaatgttga tgtatctggt tcgtttgaat ataaaatatg gcaaact      3297


<210>  5954
<211>  626
<212>  PRT
<213>  Homosapiens

<400>  5954

Met Cys Glu Val Leu Asp Ile His Asn Ile Asp Glu Gln Pro Arg Pro 
1               5                   10                  15      


Leu Thr Asp Ser His Arg Val Lys Phe Thr Lys Glu Ile Lys Gly Leu 
            20                  25                  30          


Lys Val Glu Val Thr His Cys Gly Thr Met Arg Arg Lys Tyr Arg Val 
        35                  40                  45              


Cys Asn Val Thr Arg Arg Pro Ala Ser His Gln Thr Phe Pro Leu Gln 
    50                  55                  60                  


Leu Glu Asn Gly Gln Thr Val Glu Arg Thr Val Ala Gln Tyr Phe Arg 
65                  70                  75                  80  


Glu Lys Tyr Thr Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln 
                85                  90                  95      


Val Gly Gln Glu Gln Lys His Thr Tyr Leu Pro Leu Glu Val Cys Asn 
            100                 105                 110         


Ile Val Ala Gly Gln Arg Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr 
        115                 120                 125             


Ser Thr Met Ile Lys Ala Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu 
    130                 135                 140                 


Glu Ile Ser Arg Leu Val Arg Ser Ala Asn Tyr Glu Thr Asp Pro Phe 
145                 150                 155                 160 


Val Gln Glu Phe Gln Phe Lys Val Arg Asp Glu Met Ala His Val Thr 
                165                 170                 175     


Gly Arg Val Leu Pro Ala Pro Met Leu Gln Tyr Gly Gly Arg Asn Arg 
            180                 185                 190         


Thr Val Ala Thr Pro Ser His Gly Val Trp Asp Met Arg Gly Lys Gln 
        195                 200                 205             


Phe His Thr Gly Val Glu Ile Lys Met Trp Ala Ile Ala Cys Phe Ala 
    210                 215                 220                 


Thr Gln Arg Gln Cys Arg Glu Glu Ile Leu Lys Gly Phe Thr Asp Gln 
225                 230                 235                 240 


Leu Arg Lys Ile Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln Pro 
                245                 250                 255     


Cys Phe Cys Lys Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met Phe 
            260                 265                 270         


Arg His Leu Lys Asn Thr Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile 
        275                 280                 285             


Leu Pro Gly Lys Thr Pro Val Tyr Ala Glu Val Lys Arg Val Gly Asp 
    290                 295                 300                 


Thr Leu Leu Gly Met Ala Thr Gln Cys Val Gln Val Lys Asn Val Ile 
305                 310                 315                 320 


Lys Thr Ser Pro Gln Thr Leu Ser Asn Leu Cys Leu Lys Ile Asn Val 
                325                 330                 335     


Lys Leu Gly Gly Ile Asn Asn Ile Leu Val Pro His Gln Arg Pro Ser 
            340                 345                 350         


Val Phe Gln Gln Pro Val Ile Phe Leu Gly Ala Asp Val Thr His Pro 
        355                 360                 365             


Pro Ala Gly Asp Gly Lys Lys Pro Ser Ile Ala Ala Val Val Gly Ser 
    370                 375                 380                 


Met Asp Ala His Pro Ser Arg Tyr Cys Ala Thr Val Arg Val Gln Arg 
385                 390                 395                 400 


Pro Arg Gln Glu Ile Ile Gln Asp Leu Ala Ser Met Val Arg Glu Leu 
                405                 410                 415     


Leu Ile Gln Phe Tyr Lys Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile 
            420                 425                 430         


Phe Tyr Arg Asp Gly Val Ser Glu Gly Gln Phe Arg Gln Val Leu Tyr 
        435                 440                 445             


Tyr Glu Leu Leu Ala Ile Arg Glu Ala Cys Ile Ser Leu Glu Lys Asp 
    450                 455                 460                 


Tyr Gln Pro Gly Ile Thr Tyr Ile Val Val Gln Lys Arg His His Thr 
465                 470                 475                 480 


Arg Leu Phe Cys Ala Asp Arg Thr Glu Arg Val Gly Arg Ser Gly Asn 
                485                 490                 495     


Ile Pro Ala Gly Thr Thr Val Asp Thr Asp Ile Thr His Pro Tyr Glu 
            500                 505                 510         


Phe Asp Phe Tyr Leu Cys Ser His Ala Gly Ile Gln Gly Thr Ser Arg 
        515                 520                 525             


Pro Ser His Tyr His Val Leu Trp Asp Asp Asn Cys Phe Thr Ala Asp 
    530                 535                 540                 


Glu Leu Gln Leu Leu Thr Tyr Gln Leu Cys His Thr Tyr Val Arg Cys 
545                 550                 555                 560 


Thr Arg Ser Val Ser Ile Pro Ala Pro Ala Tyr Tyr Ala His Leu Val 
                565                 570                 575     


Ala Phe Arg Ala Arg Tyr His Leu Val Asp Lys Glu His Asp Ser Ala 
            580                 585                 590         


Glu Gly Ser His Val Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala 
        595                 600                 605             


Leu Ala Lys Ala Val Gln Ile His Gln Asp Thr Leu Arg Thr Met Tyr 
    610                 615                 620                 


Phe Ala 
625     


<210>  5955
<211>  485
<212>  DNA
<213>  Homosapiens

<400>  5955
gagactgtct caaaaacaaa aaaaagaagt cagtggcctg ataaaaataa ttcacatatg     60

aaatgactac aaacataaaa aaaaaaaaga aaaaagatct aaaatataat ccctctcttc    120

tctgttttgc ataccttaaa ctttatcttg ttgcacaagt atttattggc taccttctct    180

gctagtaacc acagagtaat aaagataagt tagagattgg aaggatacaa agagagactg    240

ccagctgttt tagttgtgtt ttataaacct ctggatgatt ttgacatttt gttatacttt    300

agcaatcttc tttctgtcta tactgtagtg acacattcat ttattgtagc catggataat    360

gtcagtagac ttttggggaa aatattcttt catgttgtct tctgtagact agaataatat    420

ttttcattct gtcttttggg agcagagaat taagaggtac ctaataaagt gagatggagg    480

tggat                                                                485


<210>  5956
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5956

Met Thr Thr Asn Ile Lys Lys Lys Lys Lys Lys Asp Leu Lys Tyr Asn 
1               5                   10                  15      


Pro Ser Leu Leu Cys Phe Ala Tyr Leu Lys Leu Tyr Leu Val Ala Gln 
            20                  25                  30          


Val Phe Ile Gly Tyr Leu Leu Cys 
        35                  40  


<210>  5957
<211>  367
<212>  DNA
<213>  Homosapiens

<400>  5957
ggtctaatca atggtgctct aactacagaa cagcgaatct taacctgggg accatgggtc     60

atgaatggac tgcagaaatt ctgtgacctc ctgagaagtg ttctgggtga gacaaggctt    120

gaaagagaca aagaaggctg gagccccgtg gcagatgaga tggttagatc tgcaggcata    180

ctaactggaa gagatacaac agaggctccc tggaagaagg atgccagaca cagttgagag    240

cacaagactg taccaaaaac aagagattaa atgactttaa catattaaat gctgaataca    300

gaagttcccc cagctagaac tcccaactag gcttccagaa tgcaggcaac cacactgcta    360

tccttta                                                              367


<210>  5958
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  5958

Met Asn Gly Leu Gln Lys Phe Cys Asp Leu Leu Arg Ser Val Leu Gly 
1               5                   10                  15      


Glu Thr Arg Leu Glu Arg Asp Lys Glu Gly Trp Ser Pro Val Ala Asp 
            20                  25                  30          


Glu Met Val Arg Ser Ala Gly Ile Leu Thr Gly Arg Asp Thr Thr Glu 
        35                  40                  45              


Ala Pro Trp Lys Lys Asp Ala Arg His Ser 
    50                  55              


<210>  5959
<211>  385
<212>  DNA
<213>  Homosapiens

<400>  5959
cctaaaaata gaaaaagttt gtagttactc tcaaaattcc cccaaatccc ctactttaat     60

gcattagaac cctctttttt ttcttcactg tgtccataat atattttcca acaggtctaa    120

tcaatggtgc tctaactaca gaacagcgaa tcttaacctg gggaccatgg gtcatgaatg    180

gactgcagaa attctgtgac ctcctgatct tgctgttgcc ttgatcatag tggaagtctg    240

attgtctgtt agcttcttga tacatcgttg ccctgccaca atattacaga cctacaaatg    300

gaaaaaagtt ttgtactaca tgtatatatc tttttttttt agctcttact tagtgccaat    360

tacatgtaaa taaaaattta aaatc                                          385


<210>  5960
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  5960

Tyr Ile Val Ala Leu Pro Gln Tyr Tyr Arg Pro Thr Asn Gly Lys Lys 
1               5                   10                  15      


Phe Cys Thr Thr Cys Ile Tyr Leu Phe Phe Leu Ala Leu Thr 
            20                  25                  30  


<210>  5961
<211>  602
<212>  DNA
<213>  Homosapiens

<400>  5961
gcaacatgta agaataggaa ctaggacctg cgtagtctgc tctgaatgac tgcttaagtc     60

atatttcaag gtgaaagtag tgaaatgtag gatcagccta tgtattcata cattttttaa    120

agtgctttca gatatatttt tacctttttc ttgtttgttt aaactttaac caaacaaatc    180

taggttggaa gaagtggcaa tatcccagct ggaacaacag ttgatacaga cattacacac    240

ccatatgagt tcgattttta cctctgtagc catgctggaa tacagggtac cagtcgtcct    300

tcacactatc atgttttatg ggatgataac tgctttactg cagatgaact tcagctgcta    360

acttaccagc tctgccacac ttacgtacgc tgtacacgat ctgtttctat acctgcacca    420

gcgtattatg ctcacctggt agcatttaga gccagatatc atcttgtgga caaagaacat    480

gacaggtaat ataaaagcat aacaggttct cacccaaatc ccaatattgt ctgcatggta    540

ggattttcaa gttccacaag ctattagcgg agtcagtgat ccatgtgaaa aatgatgaca    600

ga                                                                   602


<210>  5962
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  5962

Met Ser Ser Ile Phe Thr Ser Val Ala Met Leu Glu Tyr Arg Val Pro 
1               5                   10                  15      


Val Val Leu His Thr Ile Met Phe Tyr Gly Met Ile Thr Ala Leu Leu 
            20                  25                  30          


Gln Met Asn Phe Ser Cys 
        35              


<210>  5963
<211>  1222
<212>  DNA
<213>  Homosapiens

<400>  5963
gcagcacaac tatctttgca aaaaaaagta aagaaaaagt aaatgatggt ttaaaaaata     60

cacaccttca tgaataatca aagtgatttt tcagaattat gtgtgcaaaa aattaatgtg    120

cattcatata ttcttgtaaa aggtgtctgt gtatttttaa aatatataca tccatacttc    180

atatgcatat atatctagat ctggattgat aatagatata tatgtgtctg ttatatattt    240

tagagttcat tccattgggg aattttcttt cccttttatt ctacccccac taccgccttt    300

atttctctat ttcccttgcc ttcatcacct acattttttt cccagtccta ccagtgacat    360

tcaaatgttg atgtatctgg ttcgtttgaa tataaaatat ggcaaactag aattctactt    420

ttattttgca taccctactc ctgactccta tctcatacac aattctgagt tctcaactct    480

tgatattgct gtcttaagaa acaaaatttt atatatatat gtatacatac atacacagac    540

acagacacac acatatatat acataaaata actttctgtg agagtgcgtc tctcccctcc    600

cactcagaac atacatttac catttgcgca atttgtatat aagcagtagc aacctgaact    660

attctttttc ttttttcttt ttcttttctt tctttttttt ttttaatgag acagagcctc    720

gctctgtcac caggctggag caggattgct tgaacctagg aggcggaagt tacagtgagc    780

caagactgca ccattgcact ccagcctggg caacaaaacc aaaactccgt ctcaaaagaa    840

aaaaaaatca taatgaaaat gaagtgaaat tgcctaaatg agtccaactt gaatattaga    900

aataaagttg aacttttata taattgtgaa tagcttaaca tatttaaatt atttgcaaat    960

agattgtgtt tattgaagaa tcatattggc tagatgccca ttttcattta ctaaaatgaa   1020

tcaggaaaat gcaagatgat attttaaaac ttttgctaat gtatcaccag tataactttc   1080

cttttaaaat taaggtgata gtaacaaagg aagttaggac tttgatcatt ttaaatcagt   1140

taaatcactg aaacgtggga aattgtttta caaaactttt attgattaca ctttaaggta   1200

ttaaaaagta ctataaagct at                                            1222


<210>  5964
<211>  68
<212>  PRT
<213>  Homosapiens

<400>  5964

Met Leu Met Tyr Leu Val Arg Leu Asn Ile Lys Tyr Gly Lys Leu Glu 
1               5                   10                  15      


Phe Tyr Phe Tyr Phe Ala Tyr Pro Thr Pro Asp Ser Tyr Leu Ile His 
            20                  25                  30          


Asn Ser Glu Phe Ser Thr Leu Asp Ile Ala Val Leu Arg Asn Lys Ile 
        35                  40                  45              


Leu Tyr Ile Tyr Val Tyr Ile His Thr Gln Thr Gln Thr His Thr Tyr 
    50                  55                  60                  


Ile Tyr Ile Lys 
65              


<210>  5965
<211>  492
<212>  DNA
<213>  Homosapiens

<400>  5965
aggcaggatt gcttgaacct aggaggcgga agttacagtg agccaagact gcaccattgc     60

actccagcct gggcaacaaa accaaaactc cgtctcaaaa gaaaaaaaaa tcataatgaa    120

aatgaactta acatatttaa attatttgca aatagattgt gtttattgaa gaatcatatt    180

ggctagatgc ccattttcat ttactaaaat gaatcaggaa aatgcaagat gatattttaa    240

aacttttgct aatgtatcac cagtataact ttccttttaa aattaaggtg atagtaacaa    300

aggaagttag gactttgatc attttaaatc agttaaatca ctgaaacgtg ggaaattgtt    360

ttacaaaact tttattgatt acactttaag gtattaaaaa gtactataaa gctatcaaaa    420

ctgagtttat cagtaacatt ggattcaggg gagctttgca ctttgtaact catgaaaatt    480

gcattttgat tt                                                        492


<210>  5966
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  5966

Met Gln Asp Asp Ile Leu Lys Leu Leu Leu Met Tyr His Gln Tyr Asn 
1               5                   10                  15      


Phe Pro Phe Lys Ile Lys Val Ile Val Thr Lys Glu Val Arg Thr Leu 
            20                  25                  30          


Ile Ile Leu Asn Gln Leu Asn His 
        35                  40  


<210>  5967
<211>  497
<212>  DNA
<213>  Homosapiens

<400>  5967
ctccacactg cctctcatgg ggggctggga tagagaggaa gacaggtgtg caggcctggt     60

cctgttctga ggactctgct gaaccggatc ctatgaggtt attttgtaaa ctctaatata    120

tgacttgtaa actggacatg aacaagaatt tgtgatatag cctctttacc aggattgaag    180

aagatagaaa gaaaaaaatc ttggacaaat taattgcagg aagaaatgat caaattttgg    240

cttacatatt ttgcaacagt ggtataacac aaagaagtaa gcaaatatgg cagaagtgtg    300

gtggctttgg cgtctacttt tgaccatagt ggtggccctg ttattcgtgg ctcccggggt    360

tcctacacat ccttcccgat ggaagaaggg gttggccaaa aaggtcagcc agctgatggg    420

ttggaccaag aaagacagag tgataagaat gagtgacacc atgttctatc attttgtatt    480

agatgcacca aaaaact                                                   497


<210>  5968
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  5968

Met Ala Glu Val Trp Trp Leu Trp Arg Leu Leu Leu Thr Ile Val Val 
1               5                   10                  15      


Ala Leu Leu Phe Val Ala Pro Gly Val Pro Thr His Pro Ser Arg Trp 
            20                  25                  30          


Lys Lys Gly Leu Ala Lys Lys Val Ser Gln Leu Met Gly Trp Thr Lys 
        35                  40                  45              


Lys Asp Arg Val Ile Arg Met Ser Asp Thr Met Phe Tyr His Phe Val 
    50                  55                  60                  


Leu Asp Ala Pro Lys 
65                  


<210>  5969
<211>  1510
<212>  DNA
<213>  Homosapiens

<400>  5969
tggttgccta gcaaccggtg gtgccaaaca ctggagctca gagcgggggg cgcggagagc     60

gaagcgggaa aggaggtggt gtctgtgaac aggcctaggg gtttctgacc cttctggttt    120

ctgtgccatg gccacgctga gcgtcaagcc aagtcggcgc ttccagctgc ccgactggca    180

cactaacagc tacctgctat ccaccaatgc ccagctgcag cgagatgctt cccatcagat    240

ccgccaggag gcccgggtgc tccgcaacga gaccaacaac cagaccattt gggatgaaca    300

tgacaacagg actcgactgg tggagaggat tgatactgtc aaccggtgga aggagatgct    360

ggacaagtgt ctgacagatt tagatgccga gatcgatgcc ctgacacaga tgaaggagtc    420

agcagagcaa aacctgcagg ccaagaacct gcctctggat gtggccattg agtgcctgac    480

cctgcgggaa agccggcgag acattgatgt ggtgaaggac cctgtggagg atgagctgca    540

taaagaggtg gaggtcatcg aggccaccaa gaaggccttg caacagaagg tcagccaggc    600

cttcgagcag ctctgcctct tgcaggaagt ccaacagcag ctcaactccg accatcgggg    660

caaaatggag acactagaga tcgacagagg ctgtctctct ctcaacctca gatccccaaa    720

catctcgctg aaggttgacc ccacacgtgt acctgatggc tccaccacac tccagcagtg    780

ggatgacttc agtcggttca acaaggaccg agcggaggct gagatgaagg cagccacaga    840

gctgagggag gccactgctc taactattgc tgagaccaac aacgagcttg aagcccagag    900

agttgcaacg gaatttgcct tcaggaagcg gctgcgggag atggagaaag tgtacagtga    960

gctcaagtgg caagagaaga ataccttgga ggagatcgct gagctgcagg aggacatccg   1020

gcacctggag gaggatctgc gcacaaagct cctgagcctg aagctgtccc atacccggct   1080

agaggccaga acctaccggc ccaacgtgga actctgccgg gaccaggcac agtacggcct   1140

caccgacgag gttcaccagc tagaggcaac catcgctgcc ctgaagcaga agctggcgca   1200

agcacaggac gcactggacg ccctgtgcaa gcacctggcc cggctgcagg ctgacattgc   1260

ctgcaaggcc aactccatgc tgctggacac caagtgcatg gacacacggc gcaagctgac   1320

cgtgcctgct gagaggttcg tgcctgaggt ggacaccttc acacgtacca caaatagcac   1380

cctgagtcca ctcaaaagct gccagctgga gctggcctag ccttggagga ctgcaggagg   1440

agggcagggt tgggtgggca atggaaggag ggaggagaga aatgaatgga ataaatgcag   1500

aggatctcag                                                          1510


<210>  5970
<211>  430
<212>  PRT
<213>  Homosapiens

<400>  5970

Met Ala Thr Leu Ser Val Lys Pro Ser Arg Arg Phe Gln Leu Pro Asp 
1               5                   10                  15      


Trp His Thr Asn Ser Tyr Leu Leu Ser Thr Asn Ala Gln Leu Gln Arg 
            20                  25                  30          


Asp Ala Ser His Gln Ile Arg Gln Glu Ala Arg Val Leu Arg Asn Glu 
        35                  40                  45              


Thr Asn Asn Gln Thr Ile Trp Asp Glu His Asp Asn Arg Thr Arg Leu 
    50                  55                  60                  


Val Glu Arg Ile Asp Thr Val Asn Arg Trp Lys Glu Met Leu Asp Lys 
65                  70                  75                  80  


Cys Leu Thr Asp Leu Asp Ala Glu Ile Asp Ala Leu Thr Gln Met Lys 
                85                  90                  95      


Glu Ser Ala Glu Gln Asn Leu Gln Ala Lys Asn Leu Pro Leu Asp Val 
            100                 105                 110         


Ala Ile Glu Cys Leu Thr Leu Arg Glu Ser Arg Arg Asp Ile Asp Val 
        115                 120                 125             


Val Lys Asp Pro Val Glu Asp Glu Leu His Lys Glu Val Glu Val Ile 
    130                 135                 140                 


Glu Ala Thr Lys Lys Ala Leu Gln Gln Lys Val Ser Gln Ala Phe Glu 
145                 150                 155                 160 


Gln Leu Cys Leu Leu Gln Glu Val Gln Gln Gln Leu Asn Ser Asp His 
                165                 170                 175     


Arg Gly Lys Met Glu Thr Leu Glu Ile Asp Arg Gly Cys Leu Ser Leu 
            180                 185                 190         


Asn Leu Arg Ser Pro Asn Ile Ser Leu Lys Val Asp Pro Thr Arg Val 
        195                 200                 205             


Pro Asp Gly Ser Thr Thr Leu Gln Gln Trp Asp Asp Phe Ser Arg Phe 
    210                 215                 220                 


Asn Lys Asp Arg Ala Glu Ala Glu Met Lys Ala Ala Thr Glu Leu Arg 
225                 230                 235                 240 


Glu Ala Thr Ala Leu Thr Ile Ala Glu Thr Asn Asn Glu Leu Glu Ala 
                245                 250                 255     


Gln Arg Val Ala Thr Glu Phe Ala Phe Arg Lys Arg Leu Arg Glu Met 
            260                 265                 270         


Glu Lys Val Tyr Ser Glu Leu Lys Trp Gln Glu Lys Asn Thr Leu Glu 
        275                 280                 285             


Glu Ile Ala Glu Leu Gln Glu Asp Ile Arg His Leu Glu Glu Asp Leu 
    290                 295                 300                 


Arg Thr Lys Leu Leu Ser Leu Lys Leu Ser His Thr Arg Leu Glu Ala 
305                 310                 315                 320 


Arg Thr Tyr Arg Pro Asn Val Glu Leu Cys Arg Asp Gln Ala Gln Tyr 
                325                 330                 335     


Gly Leu Thr Asp Glu Val His Gln Leu Glu Ala Thr Ile Ala Ala Leu 
            340                 345                 350         


Lys Gln Lys Leu Ala Gln Ala Gln Asp Ala Leu Asp Ala Leu Cys Lys 
        355                 360                 365             


His Leu Ala Arg Leu Gln Ala Asp Ile Ala Cys Lys Ala Asn Ser Met 
    370                 375                 380                 


Leu Leu Asp Thr Lys Cys Met Asp Thr Arg Arg Lys Leu Thr Val Pro 
385                 390                 395                 400 


Ala Glu Arg Phe Val Pro Glu Val Asp Thr Phe Thr Arg Thr Thr Asn 
                405                 410                 415     


Ser Thr Leu Ser Pro Leu Lys Ser Cys Gln Leu Glu Leu Ala 
            420                 425                 430 


<210>  5971
<211>  1752
<212>  DNA
<213>  Homosapiens

<400>  5971
gggcgtggcg gctaccagac ggggaggggg ccgccccggg ggccgccccc cagctcccca     60

gtgccaacag gcacgcgtcc ctggagacag aacagggctc ctgcccttag atcccccacg    120

gggactggcc cgcagcctgg ggaagaaagg aaaggaagat caacaaggca tggttggctg    180

ggggcaggtg gtgtctgtga acaggcctag gggtttctga cccttctggt ttctgtgcca    240

tggccacgct gagcgtcaag ccaagtcggc gcttccagct gcccgactgg cacactaaca    300

gctacctgct atccaccaat gcccagctgc agcgagatgc ttcccatcag atccgccagg    360

aggcccgggt gctccgcaac gagaccaaca accagaccat ttgggatgaa catgacaaca    420

ggactcgact ggtggagagg attgatactg tcaaccggtg gaaggagatg ctggacaagt    480

gtctgacaga tttagatgcc gagatcgatg ccctgacaca gagacggggt ttcaccattt    540

tggccaggct gttctcgaac tcctgacctc aagtgttcca tccaactcgg cctcccgaag    600

tgctgggatt acagatgtga gccaccgtgc ccggccgcgc cctcttttct agatgaagga    660

gtcagcagag caaaacctgc aggccaagaa cctgcctctg gatgtggcca ttgagtgcct    720

gaccctgcgg gaaagccggc gagacattga tgtggtgaag gaccctgtgg aggatgagct    780

gcataaagag gtggaggtca tcgaggccac caagaaggcc ttgcaacaga aggtcagcca    840

ggccttcgag cagctctgcc tcttgcagga agtccaacag cagctcaact ccgaccatcg    900

gggcaaaatg gagacactag agatcgacag aggctgtctc tctctcaacc tcagatcccc    960

aaacatctcg ctgaaggttg accccacacg tgtacctgat ggctccacca cactccagca   1020

gtgggatgac ttcagtcggt tcaacaagga ccgagcggag gctgagatga aggcagccac   1080

agagctgagg gaggccactg ctctaactat tgctgagacc aacaacgagc ttgaagccca   1140

gagagttgca acggaatttg ccttcaggaa gcggctgcgg gagatggaga aagtgtacag   1200

tgagctcaag tggcaagaga agaatacctt ggaggagatc gctgagctgc aggaggacat   1260

ccggcacctg gaggaggatc tgcgcacaaa gctcctgagc ctgaagctgt cccatacccg   1320

gctagaggcc agaacctacc ggcccaacgt ggaactctgc cgggaccagg cacagtacgg   1380

cctcaccgac gaggttcacc agctagaggc aaccatcgct gccctgaagc agaagctggc   1440

gcaagcacag gacgcactgg acgccctgtg caagcacctg gcccggctgc aggctgacat   1500

tgcctgcaag gccaactcca tgctgctgga caccaagtgc atggacacac ggcgcaagct   1560

gaccgtgcct gctgagaggt tcgtgcctga ggtggacacc ttcacacgta ccacaaatag   1620

caccctgagt ccactcaaaa gctgccagct ggagctggcc tagccttgga ggactgcagg   1680

aggagggcag ggttgggtgg gcaatggaag gagggaggag agaaatgaat ggaataaatg   1740

cagaggatct ca                                                       1752


<210>  5972
<211>  336
<212>  PRT
<213>  Homosapiens

<400>  5972

Met Lys Glu Ser Ala Glu Gln Asn Leu Gln Ala Lys Asn Leu Pro Leu 
1               5                   10                  15      


Asp Val Ala Ile Glu Cys Leu Thr Leu Arg Glu Ser Arg Arg Asp Ile 
            20                  25                  30          


Asp Val Val Lys Asp Pro Val Glu Asp Glu Leu His Lys Glu Val Glu 
        35                  40                  45              


Val Ile Glu Ala Thr Lys Lys Ala Leu Gln Gln Lys Val Ser Gln Ala 
    50                  55                  60                  


Phe Glu Gln Leu Cys Leu Leu Gln Glu Val Gln Gln Gln Leu Asn Ser 
65                  70                  75                  80  


Asp His Arg Gly Lys Met Glu Thr Leu Glu Ile Asp Arg Gly Cys Leu 
                85                  90                  95      


Ser Leu Asn Leu Arg Ser Pro Asn Ile Ser Leu Lys Val Asp Pro Thr 
            100                 105                 110         


Arg Val Pro Asp Gly Ser Thr Thr Leu Gln Gln Trp Asp Asp Phe Ser 
        115                 120                 125             


Arg Phe Asn Lys Asp Arg Ala Glu Ala Glu Met Lys Ala Ala Thr Glu 
    130                 135                 140                 


Leu Arg Glu Ala Thr Ala Leu Thr Ile Ala Glu Thr Asn Asn Glu Leu 
145                 150                 155                 160 


Glu Ala Gln Arg Val Ala Thr Glu Phe Ala Phe Arg Lys Arg Leu Arg 
                165                 170                 175     


Glu Met Glu Lys Val Tyr Ser Glu Leu Lys Trp Gln Glu Lys Asn Thr 
            180                 185                 190         


Leu Glu Glu Ile Ala Glu Leu Gln Glu Asp Ile Arg His Leu Glu Glu 
        195                 200                 205             


Asp Leu Arg Thr Lys Leu Leu Ser Leu Lys Leu Ser His Thr Arg Leu 
    210                 215                 220                 


Glu Ala Arg Thr Tyr Arg Pro Asn Val Glu Leu Cys Arg Asp Gln Ala 
225                 230                 235                 240 


Gln Tyr Gly Leu Thr Asp Glu Val His Gln Leu Glu Ala Thr Ile Ala 
                245                 250                 255     


Ala Leu Lys Gln Lys Leu Ala Gln Ala Gln Asp Ala Leu Asp Ala Leu 
            260                 265                 270         


Cys Lys His Leu Ala Arg Leu Gln Ala Asp Ile Ala Cys Lys Ala Asn 
        275                 280                 285             


Ser Met Leu Leu Asp Thr Lys Cys Met Asp Thr Arg Arg Lys Leu Thr 
    290                 295                 300                 


Val Pro Ala Glu Arg Phe Val Pro Glu Val Asp Thr Phe Thr Arg Thr 
305                 310                 315                 320 


Thr Asn Ser Thr Leu Ser Pro Leu Lys Ser Cys Gln Leu Glu Leu Ala 
                325                 330                 335     


<210>  5973
<211>  1662
<212>  DNA
<213>  Homosapiens

<400>  5973
gtagggaaac tgtgagggcg gcaccggaag tggcgagcag tctgcgcgcg gatggccgca     60

gcggcgatgg cggcagcggc aggtggaggg gctggcgcgg cccgctccct ctcgcgcttc    120

cgaggctgcc tggctggcgc gctgctcggg gactgcgtgg gctccttcta cgaggcccac    180

gacaccgtcg acctgacgtc agtcctgcgt catgtccaga gtctggaaca gaagccttgt    240

actacacaga tgacacagcc atggccaggg ccctggtgca gtccctgcta gccaaggagg    300

cctttgacga ggtggacatg gctcacagat ttgctcagga gtacaagaaa gaccctgaca    360

ggggctatgg tgctggagta gtcactgtct tcaagaagct cctgaacccc aaatgtcgcg    420

atgtctttga gcctgcccgg gcccagttta acgggaaagg ctcctatggc aatggaggtg    480

ccatgcgggt ggctggcatc tccctggcct atagcagtgt ccaggatgtg cagaagtttg    540

cccggctctc ggcccagctg acacacgcct cctccctggg ttacaatggc gccatcctgc    600

aggccctggc tgtgcacctg gccttgcagg gcgagtcttc cagcgagcac tttctcaagc    660

aactcctggg ccacatggag gatctggagg gtgatgccca gtccgtcttg gatgccaggg    720

agttgggcat ggaggagcgt ccatactcca gccgcctgaa gaagattgga gagcttctag    780

accaggcatc ggtgaccagg gaggaagtgg tgtctgagct agggaatggc attgctgcct    840

ttgagtcggt acccaccgcc atctactgct tcctacgctg catggagcca gaccctgaga    900

tcccttctgc cttcaatagc ctccaaagga ctctcattta ttccatctca cttggtgggg    960

acacagacac cattgccacc atggctgggg ccattgctgg tgcctactat gggatggatc   1020

aggtgccaga gagctggcag caaagctgtg aaggctacga ggagacagac atcctggccc   1080

aaagcctgca ccgtgtcttc cagaagagtt gatgagggct acagctgttg gggctctgcc   1140

aggtcccctg ggaccaacta cagctccaat cagaaaccct gcgcttcctt gagtgtggct   1200

tcccactttt cctgcattgt ggagctgact gagtacaccg gtgaggctgg ggtctctgca   1260

ggggaggtca ctggaacagc gagcaaggga ctggtgcctc gctggtgctg ggtctctggt   1320

ttgctgcaga gccgtaggac actcctggct cctcagtagg acagacagac gcaggcgggt   1380

ttattttgga ggggtacttg tggcattttc ctgtattgtc ttggacatgg gatgtgggga   1440

ggtggaaatg atgagcagta gcatcatttc tccctgttgg gttttagcca gtttgccagc   1500

aagcgcatcc tagcagggtc cccgagcagc aggttgtgtg gatgaaggga caggcacttg   1560

catccagctg atctaggtca cacctggctc ttggctgcca tgtggcttat taacagcttc   1620

cagtggaagt cgcaataaac agtttttggt aaatctcacc ac                      1662


<210>  5974
<211>  283
<212>  PRT
<213>  Homosapiens

<400>  5974

Met Ala Arg Ala Leu Val Gln Ser Leu Leu Ala Lys Glu Ala Phe Asp 
1               5                   10                  15      


Glu Val Asp Met Ala His Arg Phe Ala Gln Glu Tyr Lys Lys Asp Pro 
            20                  25                  30          


Asp Arg Gly Tyr Gly Ala Gly Val Val Thr Val Phe Lys Lys Leu Leu 
        35                  40                  45              


Asn Pro Lys Cys Arg Asp Val Phe Glu Pro Ala Arg Ala Gln Phe Asn 
    50                  55                  60                  


Gly Lys Gly Ser Tyr Gly Asn Gly Gly Ala Met Arg Val Ala Gly Ile 
65                  70                  75                  80  


Ser Leu Ala Tyr Ser Ser Val Gln Asp Val Gln Lys Phe Ala Arg Leu 
                85                  90                  95      


Ser Ala Gln Leu Thr His Ala Ser Ser Leu Gly Tyr Asn Gly Ala Ile 
            100                 105                 110         


Leu Gln Ala Leu Ala Val His Leu Ala Leu Gln Gly Glu Ser Ser Ser 
        115                 120                 125             


Glu His Phe Leu Lys Gln Leu Leu Gly His Met Glu Asp Leu Glu Gly 
    130                 135                 140                 


Asp Ala Gln Ser Val Leu Asp Ala Arg Glu Leu Gly Met Glu Glu Arg 
145                 150                 155                 160 


Pro Tyr Ser Ser Arg Leu Lys Lys Ile Gly Glu Leu Leu Asp Gln Ala 
                165                 170                 175     


Ser Val Thr Arg Glu Glu Val Val Ser Glu Leu Gly Asn Gly Ile Ala 
            180                 185                 190         


Ala Phe Glu Ser Val Pro Thr Ala Ile Tyr Cys Phe Leu Arg Cys Met 
        195                 200                 205             


Glu Pro Asp Pro Glu Ile Pro Ser Ala Phe Asn Ser Leu Gln Arg Thr 
    210                 215                 220                 


Leu Ile Tyr Ser Ile Ser Leu Gly Gly Asp Thr Asp Thr Ile Ala Thr 
225                 230                 235                 240 


Met Ala Gly Ala Ile Ala Gly Ala Tyr Tyr Gly Met Asp Gln Val Pro 
                245                 250                 255     


Glu Ser Trp Gln Gln Ser Cys Glu Gly Tyr Glu Glu Thr Asp Ile Leu 
            260                 265                 270         


Ala Gln Ser Leu His Arg Val Phe Gln Lys Ser 
        275                 280             


<210>  5975
<211>  1680
<212>  DNA
<213>  Homosapiens

<400>  5975
gtagggaaac tgtgagggcg gcaccggaag tggcgagcag tctgcgcgcg gatggccgca     60

gcggcgatgg cggcagcggc aggtggaggg gctggcgcgg cccgctccct ctcgcgcttc    120

cgaggctgcc tggctggcgc gctgctcggg gactgcgtgg gctccttcta cgaggcccac    180

gacaccgtcg acctgacgtc agtcctgcgt catgtccaga gtctggagcc ggaccccggc    240

acgcccggga gtgagcggac agatttgctc aggagtacaa gaaagaccct gacaggggct    300

atggtgctgg agtagtcact gtcttcaaga agctcctgaa ccccaaatgt cgcgatgtct    360

ttgagcctgc ccgggcccag tttaacggga aaggctccta tggcaatgga ggtgccatgc    420

gggtggctgg catctccctg gcctatagca gtgtccagga tgtgcagaag gtattcaggg    480

cgggctggct tctgggctgt ccccttcctc ttctgcagca gggcttctgt gacagcaggt    540

ctcctcctcc ctagtttgcc cggctctcgg cccagctgac acacgcctcc tccctgggtt    600

acaatggcgc catcctgcag gccctggctg tgcacctggc cttgcagggc gagtcttcca    660

gcgagcactt tctcaagcaa ctcctgggcc acatggagga tctggagggt gatgcccagt    720

ccgtcttgga tgccagggag ttgggcatgg aggagcgtcc atactccagc cgcctgaaga    780

agattggaga gcttctagac caggcatcgg tgaccaggga ggaagtggtg tctgagctag    840

ggaatggcat tgctgccttt gagtcggtac ccaccgccat ctactgcttc ctacgctgca    900

tggagccaga ccctgagatc ccttctgcct tcaatagcct ccaaaggact ctcatttatt    960

ccatctcact tggtggggac acagacacca ttgccaccat ggctggggcc attgctggtg   1020

cctactatgg gatggatcag gtgccagaga gctggcagca aagctgtgaa ggctacgagg   1080

agacagacat cctggcccaa agcctgcacc gtgtcttcca gaagagttga tgagggctac   1140

agctgttggg gctctgccag gtcccctggg accaactaca gctccaatca gaaaccctgc   1200

gcttccttga gtgtggcttc ccacttttcc tgcattgtgg agctgactga gtacaccggt   1260

gaggctgggg tctctgcagg ggaggtcact ggaacagcga gcaagggact ggtgcctcgc   1320

tggtgctggg tctctggttt gctgcagagc cgtaggacac tcctggctcc tcagtaggac   1380

agacagacgc aggcgggttt attttggagg ggtacttgtg gcattttcct gtattgtctt   1440

ggacatggga tgtggggagg tggaaatgat gagcagtagc atcatttctc cctgttgggt   1500

tttagccagt ttgccagcaa gcgcatccta gcagggtccc cgagcagcag gttgtgtgga   1560

tgaagggaca ggcacttgca tccagctgat ctaggtcaca cctggctctt ggctgccatg   1620

tggcttatta acagcttcca gtggaagtcg caataaacag tttttggtaa atctcaccac   1680


<210>  5976
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  5976

Met Glu Asp Leu Glu Gly Asp Ala Gln Ser Val Leu Asp Ala Arg Glu 
1               5                   10                  15      


Leu Gly Met Glu Glu Arg Pro Tyr Ser Ser Arg Leu Lys Lys Ile Gly 
            20                  25                  30          


Glu Leu Leu Asp Gln Ala Ser Val Thr Arg Glu Glu Val Val Ser Glu 
        35                  40                  45              


Leu Gly Asn Gly Ile Ala Ala Phe Glu Ser Val Pro Thr Ala Ile Tyr 
    50                  55                  60                  


Cys Phe Leu Arg Cys Met Glu Pro Asp Pro Glu Ile Pro Ser Ala Phe 
65                  70                  75                  80  


Asn Ser Leu Gln Arg Thr Leu Ile Tyr Ser Ile Ser Leu Gly Gly Asp 
                85                  90                  95      


Thr Asp Thr Ile Ala Thr Met Ala Gly Ala Ile Ala Gly Ala Tyr Tyr 
            100                 105                 110         


Gly Met Asp Gln Val Pro Glu Ser Trp Gln Gln Ser Cys Glu Gly Tyr 
        115                 120                 125             


Glu Glu Thr Asp Ile Leu Ala Gln Ser Leu His Arg Val Phe Gln Lys 
    130                 135                 140                 


Ser 
145 


<210>  5977
<211>  1596
<212>  DNA
<213>  Homosapiens

<400>  5977
gtagggaaac tgtgagggcg gcaccggaag tggcgagcag tctgcgcgcg gatggccgca     60

gcggcgatgg cggcagcggc aggtggaggg gctggcgcgg cccgctccct ctcgcgcttc    120

cgaggctgcc tggctggcgc gctgctcggg gactgcgtgg gctccttcta cgaggcccac    180

gacaccgtcg acctgacgtc agtcctgcgt catgtccaga gtctggagcc ggaccccggc    240

acgcccggga gtgagcggac agatttgctc aggagtacaa gaaagaccct gacaggggct    300

atggtgctgg agtagtcact gtcttcaaga agctcctgaa ccccaaatgt cgcgatgtct    360

ttgagcctgc ccgggcccag tttaacggga aaggctccta tggcaatgga ggtgccatgc    420

gggtggctgg catctccctg gcctatagca gtgtccagga tgtgcagaag tttgcccggc    480

tctcggccca gctgacacac gcctcctccc tgggttacaa tggcgccatc ctgcaggccc    540

tggctgtgca cctggccttg cagggcgagt cttccagcga gcactttctc aagcaactcc    600

tgggccacat ggaggatctg gagggtgatg cccagtccgt cttggatgcc agggagttgg    660

gcatggagga gcgtccatac tccagccgcc tgaagaagat tggagagctt ctagaccagg    720

catcggtgac cagggaggaa gtggtgtctg agctagggaa tggcattgct gcctttgagt    780

cggtacccac cgccatctac tgcttcctac gctgcatgga gccagaccct gagatccctt    840

ctgccttcaa tagcctccaa aggactctca tttattccat ctcacttggt ggggacacag    900

acaccattgc caccatggct ggggccattg ctggtgccta ctatgggatg gatcaggtgc    960

cagagagctg gcagcaaagc tgtgaaggct acgaggagac agacatcctg gcccaaagcc   1020

tgcaccgtgt cttccagaag agttgatgag ggctacagct gttggggctc tgccaggtcc   1080

cctgggacca actacagctc caatcagaaa ccctgcgctt ccttgagtgt ggcttcccac   1140

ttttcctgca ttgtggagct gactgagtac accggtgagg ctggggtctc tgcaggggag   1200

gtcactggaa cagcgagcaa gggactggtg cctcgctggt gctgggtctc tggtttgctg   1260

cagagccgta ggacactcct ggctcctcag taggacagac agacgcaggc gggtttattt   1320

tggaggggta cttgtggcat tttcctgtat tgtcttggac atgggatgtg gggaggtgga   1380

aatgatgagc agtagcatca tttctccctg ttgggtttta gccagtttgc cagcaagcgc   1440

atcctagcag ggtccccgag cagcaggttg tgtggatgaa gggacaggca cttgcatcca   1500

gctgatctag gtcacacctg gctcttggct gccatgtggc ttattaacag cttccagtgg   1560

aagtcgcaat aaacagtttt tggtaaatct caccac                             1596


<210>  5978
<211>  209
<212>  PRT
<213>  Homosapiens

<400>  5978

Met Arg Val Ala Gly Ile Ser Leu Ala Tyr Ser Ser Val Gln Asp Val 
1               5                   10                  15      


Gln Lys Phe Ala Arg Leu Ser Ala Gln Leu Thr His Ala Ser Ser Leu 
            20                  25                  30          


Gly Tyr Asn Gly Ala Ile Leu Gln Ala Leu Ala Val His Leu Ala Leu 
        35                  40                  45              


Gln Gly Glu Ser Ser Ser Glu His Phe Leu Lys Gln Leu Leu Gly His 
    50                  55                  60                  


Met Glu Asp Leu Glu Gly Asp Ala Gln Ser Val Leu Asp Ala Arg Glu 
65                  70                  75                  80  


Leu Gly Met Glu Glu Arg Pro Tyr Ser Ser Arg Leu Lys Lys Ile Gly 
                85                  90                  95      


Glu Leu Leu Asp Gln Ala Ser Val Thr Arg Glu Glu Val Val Ser Glu 
            100                 105                 110         


Leu Gly Asn Gly Ile Ala Ala Phe Glu Ser Val Pro Thr Ala Ile Tyr 
        115                 120                 125             


Cys Phe Leu Arg Cys Met Glu Pro Asp Pro Glu Ile Pro Ser Ala Phe 
    130                 135                 140                 


Asn Ser Leu Gln Arg Thr Leu Ile Tyr Ser Ile Ser Leu Gly Gly Asp 
145                 150                 155                 160 


Thr Asp Thr Ile Ala Thr Met Ala Gly Ala Ile Ala Gly Ala Tyr Tyr 
                165                 170                 175     


Gly Met Asp Gln Val Pro Glu Ser Trp Gln Gln Ser Cys Glu Gly Tyr 
            180                 185                 190         


Glu Glu Thr Asp Ile Leu Ala Gln Ser Leu His Arg Val Phe Gln Lys 
        195                 200                 205             


Ser 
    


<210>  5979
<211>  1693
<212>  DNA
<213>  Homosapiens

<400>  5979
gtagggaaac tgtgagggcg gcaccggaag tggcgagcag tctgcgcgcg gatggccgca     60

gcggcgatgg cggcagcggc aggtggaggg gctggcgcgg cccgctccct ctcgcgcttc    120

cgaggctgcc tggctggcgc gctgctcggg gactgcgtgg gctccttcta cgaggcccac    180

gacaccgtcg acctgacgtc agtcctgcgt catgtccaga gtctggagcc ggaccccggc    240

acgcccggga gtgagcggac agaagccttg tactacacag atgacacagc catggccagg    300

gccctggtgc agtccctgct agccaaggag gcctttgacg aggtggacat ggctcacaga    360

tttgctcagg agtacaagaa agaccctgac aggggctatg gtgctggagt agtcactgtc    420

ttcaagaagc tcctgaaccc caaatgtcgc gatgtctttg agcctgcccg ggcccagttt    480

aacgggaaag gctcctatgg caatggaggt gccatgcggg tggctggcat ctccctggcc    540

tatagcagtg tccaggatgt gcagaagttt gcccggctct cggcccagct gacacacgcc    600

tcctccctgg gttacaatgg cgccatcctg caggccctgg ctgtgcacct ggccttgcag    660

ggcgagtctt ccagcgagca ctttctcaag caactcctgg gccacatgga ggatctggag    720

ggtgatgccc agtccgtctt ggatgccagg gagttgggca tggaggagcg tccatactcc    780

agccgcctga agaagattgg agagcttcta gaccaggcat cggtgaccag ggaggaagtg    840

gtgtctgagc tagggaatgg cattgctgcc tttgagtcgg tacccaccgc catctactgc    900

ttcctacgct gcatggagcc agaccctgag atcccttctg ccttcaatag cctccaaagg    960

actctcattt attccatctc acttggtggg gacacagaca ccattgccac catggctggg   1020

gccattgctg gtgcctacta tgggatggat caggtgccag agagctggca gcaaagctgt   1080

gaaggctacg aggagacaga catcctggcc caaagcctgc accgtgtctt ccagaagagt   1140

tgatgagggc tacagctgtt ggggctctgc caggtcccct gggaccaact acagctccaa   1200

tcagaaaccc tgcgcttcct tgagtgtggc ttcccacttt tcctgcattg tggagctgac   1260

tgagtacacc ggtgaggctg gggtctctgc aggggaggtc actggaacag cgagcaaggg   1320

actggtgcct cgctggtgct gggtctctgg tttgctgcag agccgtagga cactcctggc   1380

tcctcagtag gacagacaga cgcaggcggg tttattttgg aggggtactt gtggcatttt   1440

cctgtattgt cttggacatg ggatgtgggg aggtggaaat gatgagcagt agcatcattt   1500

ctccctgttg ggttttagcc agtttgccag caagcgcatc ctagcagggt ccccgagcag   1560

caggttgtgt ggatgaaggg acaggcactt gcatccagct gatctaggtc acacctggct   1620

cttggctgcc atgtggctta ttaacagctt ccagtggaag tcgcaataaa cagtttttgg   1680

taaatctcac cac                                                      1693


<210>  5980
<211>  363
<212>  PRT
<213>  Homosapiens

<400>  5980

Met Ala Ala Ala Ala Met Ala Ala Ala Ala Gly Gly Gly Ala Gly Ala 
1               5                   10                  15      


Ala Arg Ser Leu Ser Arg Phe Arg Gly Cys Leu Ala Gly Ala Leu Leu 
            20                  25                  30          


Gly Asp Cys Val Gly Ser Phe Tyr Glu Ala His Asp Thr Val Asp Leu 
        35                  40                  45              


Thr Ser Val Leu Arg His Val Gln Ser Leu Glu Pro Asp Pro Gly Thr 
    50                  55                  60                  


Pro Gly Ser Glu Arg Thr Glu Ala Leu Tyr Tyr Thr Asp Asp Thr Ala 
65                  70                  75                  80  


Met Ala Arg Ala Leu Val Gln Ser Leu Leu Ala Lys Glu Ala Phe Asp 
                85                  90                  95      


Glu Val Asp Met Ala His Arg Phe Ala Gln Glu Tyr Lys Lys Asp Pro 
            100                 105                 110         


Asp Arg Gly Tyr Gly Ala Gly Val Val Thr Val Phe Lys Lys Leu Leu 
        115                 120                 125             


Asn Pro Lys Cys Arg Asp Val Phe Glu Pro Ala Arg Ala Gln Phe Asn 
    130                 135                 140                 


Gly Lys Gly Ser Tyr Gly Asn Gly Gly Ala Met Arg Val Ala Gly Ile 
145                 150                 155                 160 


Ser Leu Ala Tyr Ser Ser Val Gln Asp Val Gln Lys Phe Ala Arg Leu 
                165                 170                 175     


Ser Ala Gln Leu Thr His Ala Ser Ser Leu Gly Tyr Asn Gly Ala Ile 
            180                 185                 190         


Leu Gln Ala Leu Ala Val His Leu Ala Leu Gln Gly Glu Ser Ser Ser 
        195                 200                 205             


Glu His Phe Leu Lys Gln Leu Leu Gly His Met Glu Asp Leu Glu Gly 
    210                 215                 220                 


Asp Ala Gln Ser Val Leu Asp Ala Arg Glu Leu Gly Met Glu Glu Arg 
225                 230                 235                 240 


Pro Tyr Ser Ser Arg Leu Lys Lys Ile Gly Glu Leu Leu Asp Gln Ala 
                245                 250                 255     


Ser Val Thr Arg Glu Glu Val Val Ser Glu Leu Gly Asn Gly Ile Ala 
            260                 265                 270         


Ala Phe Glu Ser Val Pro Thr Ala Ile Tyr Cys Phe Leu Arg Cys Met 
        275                 280                 285             


Glu Pro Asp Pro Glu Ile Pro Ser Ala Phe Asn Ser Leu Gln Arg Thr 
    290                 295                 300                 


Leu Ile Tyr Ser Ile Ser Leu Gly Gly Asp Thr Asp Thr Ile Ala Thr 
305                 310                 315                 320 


Met Ala Gly Ala Ile Ala Gly Ala Tyr Tyr Gly Met Asp Gln Val Pro 
                325                 330                 335     


Glu Ser Trp Gln Gln Ser Cys Glu Gly Tyr Glu Glu Thr Asp Ile Leu 
            340                 345                 350         


Ala Gln Ser Leu His Arg Val Phe Gln Lys Ser 
        355                 360             


<210>  5981
<211>  1136
<212>  DNA
<213>  Homosapiens

<400>  5981
cagctggcca ctagtcgtaa aaatgttgat aatggatttt atttgtctag catctatact     60

gggcgttgtg cagaatgctt cacagacacg atctcgcttc atcctcacaa cagccctgtc    120

agagagttgc taacgttact ccctgtctgc ttaaggagtt gaatctggga gcaggaagct    180

tagcggtccc ctaggtaact ctcccagtca cgcagccagt gtgtggtgga gccaggattt    240

gagcccaggt ggtctaactg tagagcctga gatcttagtc acagcctgct tgaagccgag    300

agtgctgact tgtgtcaaat ggtaggaggc ctggggaagc atgcagcccc tctaacctgg    360

cttccccaca gggaatggca ttgctgcctt tgagtcggta cccaccgcca tctactgctt    420

cctacgctgc atggagccag accctgagat cccttctgcc ttcaatagcc tccaaaggac    480

tctcatttat tccatctcac ttggtgggga cacagacacc attgccacca tggctggggc    540

cattgctggt gcctactatg ggatggatca ggtgccagag agctggcagc aaagctgtga    600

aggctacgag gagacagaca tcctggccca aagcctgcac cgtgtcttcc aaaaccctgc    660

gcttccttga gtgtggcttc ccacttttcc tgcattgtgg agctgactga gtacaccggt    720

gaggctgggg tctctgcagg ggaggtcact ggaacagcga gcaagggact ggtgcctcgc    780

tggtgctggg tctctggttt gctgcagagc cgtaggacac tcctggctcc tcagtaggac    840

agacagacgc aggcgggttt attttggagg ggtacttgtg gcattttcct gtattgtctt    900

ggacatggga tgtggggagg tggaaatgat gagcagtagc atcatttctc cctgttgggt    960

tttagccagt ttgccagcaa gcgcatccta gcagggtccc cgagcagcag gttgtgtgga   1020

tgaagggaca ggcacttgca tccagctgat ctaggtcaca cctggctctt ggctgccatg   1080

tggcttatta acagcttcca gtggaagtcg caataaacag tttttggtaa atctca       1136


<210>  5982
<211>  111
<212>  PRT
<213>  Homosapiens

<400>  5982

Met Ala Leu Leu Pro Leu Ser Arg Tyr Pro Pro Pro Ser Thr Ala Ser 
1               5                   10                  15      


Tyr Ala Ala Trp Ser Gln Thr Leu Arg Ser Leu Leu Pro Ser Ile Ala 
            20                  25                  30          


Ser Lys Gly Leu Ser Phe Ile Pro Ser His Leu Val Gly Thr Gln Thr 
        35                  40                  45              


Pro Leu Pro Pro Trp Leu Gly Pro Leu Leu Val Pro Thr Met Gly Trp 
    50                  55                  60                  


Ile Arg Cys Gln Arg Ala Gly Ser Lys Ala Val Lys Ala Thr Arg Arg 
65                  70                  75                  80  


Gln Thr Ser Trp Pro Lys Ala Cys Thr Val Ser Ser Lys Thr Leu Arg 
                85                  90                  95      


Phe Leu Glu Cys Gly Phe Pro Leu Phe Leu His Cys Gly Ala Asp 
            100                 105                 110     


<210>  5983
<211>  4451
<212>  DNA
<213>  Homosapiens

<400>  5983
ggacgccatg ctggggactc tgacacccct gtcttcgctg ctgctgctgc tactggtgct     60

ggtgctgggg tgtgggccgc gggcgtcctc tggtggcggg gccggtgggg cggcgggcta    120

tgccccagtg aagtacatcc agcccatgca gaaaggacct gtgggaccgc ccttccgtga    180

gggcaaaggc cagtacctgg aaatgcctct accgctgctg ccgatggacc tgaagggaga    240

gcccggcccc cctgggaagc ccgggcctcg gggtccccct ggcccccctg gcttcccagg    300

aaaaccaggc atgggaaagc caggactcca tgggcagcct ggccctgctg ggccccctgg    360

cttctcccgg atgggcaagg ctggtccccc agggctccct ggcaaggtcg ggccaccagg    420

gcagccgggg cttcgggggg agccaggaat acgaggggac cagggcctcc ggggaccccc    480

aggaccccct ggcctcccgg gcccctcagg cattactatc cctggaaaac caggtgccca    540

aggggtgcca gggcccccag gattccaggg ggaaccaggg ccccaggggg agcctgggcc    600

cccaggtgat cgaggcctca agggggataa tggagtgggc cagcccgggc tgcctggggc    660

cccagggcag gggggtgccc ccggcccccc cggcctccct ggtccagctg gcttaggcaa    720

acctggtttg gatgggcttc ctggggcccc aggagacaag ggtgagtctg ggcctcctgg    780

agttccaggc cccagggggg agccaggagc tgtgggccca aaaggacctc ctggagtaga    840

cggtgtggga gtcccagggg cagcagggtt gccaggacca cagggcccat caggggccaa    900

aggggagcca gggacccggg gcccccctgg gctgataggc cccactggct atgggatgcc    960

aggactgcca ggccccaagg gggacagggg cccagctggg gtcccaggac tcttggggga   1020

caggggtgag ccaggggagg atggggagcc aggggagcag ggcccacagg gtcttggggg   1080

tccccctgga cttcctgggt ctgcagggct tcctggcaga cgtgggcccc ctgggcctaa   1140

gggtgaggca gggcctggag gacccccagg agtgcctggc attcgaggtg accaggggcc   1200

tagtggcctg gctgggaaac caggggtccc aggtgagagg ggacttcctg gggcccatgg   1260

accccctgga ccaactgggc ccaagggtga gccgggtttc acgggtcgcc ctggaggacc   1320

aggggtggca ggagccctgg ggcagaaagg tgacttgggg ctccctgggc agcctggcct   1380

gaggggtccc tcaggaatcc caggactcca gggtccagct ggccctattg ggccccaagg   1440

cctgccgggc ctgaaggggg aaccaggcct gccagggccc cctggagagg ggagagcagg   1500

ggaacctggc acggctgggc ccacggggcc cccaggggtc cctggctccc ctggaatcac   1560

gggccctccg gggcctcccg ggcccccggg accccctggt gcccctgggg ccttcgatga   1620

gactggcatc gcaggcttgc acctgcccaa cggcggtgtg gagggtgccg tgctgggcaa   1680

ggggggcaag ccacagtttg ggctgggcga gctgtctgcc catgccacac cggccttcac   1740

tgcggtgctc acctcgccct tccccgcctc gggcatgccc gtgaaatttg accggactct   1800

ctacaatggc cacagcggct acaacccagc cactggcatc ttcacctgcc ctgtgggcgg   1860

cgtctactac tttgcttacc atgtgcacgt caagggcacc aacgtgtggg tggccctgta   1920

caagaacaac gtgccggcca cctataccta cgatgagtac aagaagggct acctggacca   1980

ggcatctggt ggggccgtgc tccagctgcg gcccaacgac caggtctggg tgcagatgcc   2040

gtcggaccag gccaacggcc tctactccac ggagtacatc cactcctcct tttcaggatt   2100

cttgctctgc cccacataac ccgcgggggg ggtcctgctg ccctggcctc ctccccttta   2160

gtggtagagc gaccttttca attacaaaga acctcctgga aaaaaaaaca aaagctgaac   2220

agaggcggcc gtggccttgg cccgaggaga ctaacttgct ttctccctgc atgcaggctg   2280

agattgtttc tggaaggggc tggcctgagt ttctttcccc caaatgtctg tgcagtgtca   2340

gggctgcacc ccataggccc tgaggcacac agcccagccc cttgtgagtc ctggcctctg   2400

ctgggccctg aaggagctga gagggagctc aactccccac cccgccacgt ggggagacag   2460

cccttcccac tggctccctg atggcacctg ctggaggaaa ggggcacggc ctccctcaca   2520

gcccttggct ggggctcctc cagctccccc tgggacctcc agcatatgac agtggactaa   2580

ggactgtggg gttttcctcc aaggggaagg gagaagaggg gaccatcgag gtggcgagtg   2640

tggacaccct gccaggactg cagcccccat ggtgatgctg tggcatcaga catgtccgtg   2700

gtgggcacag tgcctgttgc cctgggaaag ggcaacctcc ctttcactgc tccagtggca   2760

gccatgggga aggcagtttg tgagggcttg gggcacagac ctggggcagg aggcagctct   2820

tcacgttcat ccctgtctct cccgggctgc ccccgccagc tctggctgtt tagcttgagg   2880

gcagcacaga ggcccctggg acacctacag gccagaaaga tcaacctctg tgaagtgtct   2940

agaagtatct agtgcagatg gtggcggagg cagaatcgac catcagcaaa catgagcact   3000

cttccctttc tccccttcca cctgctgcgg gctgggctgg ttttctcaat acaaaattgt   3060

aagaggatcc ttgtcacccc agccaggtat ccccaaggca gagcacctct cgtttggccc   3120

tctgaacaag gtgcacgcga gctgggggat gaagacggct cccacttcct tttccttaat   3180

aagaaccata tggtgggtgt atgtgtgtac aagaggggtt catctgtggg ggcttcctct   3240

ccttccaccc tctggttcca atttcctgtt ctaagcagga ctagggccca ggaggctaag   3300

gctgggagag aaagggtgcc aacaggtccc ttgggaatga gttggctctg gacgtttctg   3360

ccctgttccc cgatcagagc tcctctgcag gaaacaggca ggatgcccct cccaacccct   3420

cagtccctac gtcaagcgga gtggataagg ctgagatgag tgctgggagt ggtggacatt   3480

cctgctcgtg caaagatggc cactttcccc gcagctgcag ggcctcgcgc tcggccctcg   3540

ccaggccagc cccactcctt gtaccaagtg tgaactgggg tcattcggtc tgtgatctcg   3600

ttgcactgct ccaagtctgg ctgtgtccag gcggtccatg ttgaaaatgg aggatggctg   3660

ctgacttctg actggctgag cagtgggttc cttcaggttc cttgccaacc ctcctcccct   3720

gcccacaact tctccaaaca aagcaggctg tttgctcact tcttcaaaag gaggaatgat   3780

aacccaaatc tgcccaagtg acacttgaga aggttttggc tggggttcct ggtggatttc   3840

ttactaccta acgcccaaga aaaccaacta aggactctca aaccatacct ggtgggggtt   3900

cttcgctcaa cctcttcttc cctaggtcaa agccactatc atctgatgtg ttagggatgg   3960

gttctgattg gcagaaatta atcagctccc aatgggagcc cacggaacta agtagggtcc   4020

caagaaaaaa aacgggagct atttcacaga gctgagcttc tgccaaattt cattcctcaa   4080

acctttcagg aggggtggtt ggcgtttcta aaatgtttat gggatttgag ttgcaggtgt   4140

ccacttaact gactagcttt gataaacaat gtcagatttt aactatgaaa acgacattac   4200

cttgtgcatt tttatattga ttcctatttt ttttttaaga ttaaagttta aatgttttcc   4260

actagtcatt tcacttctaa cttggtatag gaagcttagc tctctacata cctatcatgt   4320

gccctgtatc acagaagatt caggaaaaat gcacttggga atcaaagaaa atggaacttc   4380

tttttgaaaa gacaagcaac catgttaact gtattgacac atcctcaata aaacctgttg   4440

tataaaacag c                                                        4451


<210>  5984
<211>  703
<212>  PRT
<213>  Homosapiens

<400>  5984

Met Leu Gly Thr Leu Thr Pro Leu Ser Ser Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Val Leu Gly Cys Gly Pro Arg Ala Ser Ser Gly Gly Gly Ala 
            20                  25                  30          


Gly Gly Ala Ala Gly Tyr Ala Pro Val Lys Tyr Ile Gln Pro Met Gln 
        35                  40                  45              


Lys Gly Pro Val Gly Pro Pro Phe Arg Glu Gly Lys Gly Gln Tyr Leu 
    50                  55                  60                  


Glu Met Pro Leu Pro Leu Leu Pro Met Asp Leu Lys Gly Glu Pro Gly 
65                  70                  75                  80  


Pro Pro Gly Lys Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Phe 
                85                  90                  95      


Pro Gly Lys Pro Gly Met Gly Lys Pro Gly Leu His Gly Gln Pro Gly 
            100                 105                 110         


Pro Ala Gly Pro Pro Gly Phe Ser Arg Met Gly Lys Ala Gly Pro Pro 
        115                 120                 125             


Gly Leu Pro Gly Lys Val Gly Pro Pro Gly Gln Pro Gly Leu Arg Gly 
    130                 135                 140                 


Glu Pro Gly Ile Arg Gly Asp Gln Gly Leu Arg Gly Pro Pro Gly Pro 
145                 150                 155                 160 


Pro Gly Leu Pro Gly Pro Ser Gly Ile Thr Ile Pro Gly Lys Pro Gly 
                165                 170                 175     


Ala Gln Gly Val Pro Gly Pro Pro Gly Phe Gln Gly Glu Pro Gly Pro 
            180                 185                 190         


Gln Gly Glu Pro Gly Pro Pro Gly Asp Arg Gly Leu Lys Gly Asp Asn 
        195                 200                 205             


Gly Val Gly Gln Pro Gly Leu Pro Gly Ala Pro Gly Gln Gly Gly Ala 
    210                 215                 220                 


Pro Gly Pro Pro Gly Leu Pro Gly Pro Ala Gly Leu Gly Lys Pro Gly 
225                 230                 235                 240 


Leu Asp Gly Leu Pro Gly Ala Pro Gly Asp Lys Gly Glu Ser Gly Pro 
                245                 250                 255     


Pro Gly Val Pro Gly Pro Arg Gly Glu Pro Gly Ala Val Gly Pro Lys 
            260                 265                 270         


Gly Pro Pro Gly Val Asp Gly Val Gly Val Pro Gly Ala Ala Gly Leu 
        275                 280                 285             


Pro Gly Pro Gln Gly Pro Ser Gly Ala Lys Gly Glu Pro Gly Thr Arg 
    290                 295                 300                 


Gly Pro Pro Gly Leu Ile Gly Pro Thr Gly Tyr Gly Met Pro Gly Leu 
305                 310                 315                 320 


Pro Gly Pro Lys Gly Asp Arg Gly Pro Ala Gly Val Pro Gly Leu Leu 
                325                 330                 335     


Gly Asp Arg Gly Glu Pro Gly Glu Asp Gly Glu Pro Gly Glu Gln Gly 
            340                 345                 350         


Pro Gln Gly Leu Gly Gly Pro Pro Gly Leu Pro Gly Ser Ala Gly Leu 
        355                 360                 365             


Pro Gly Arg Arg Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Pro Gly 
    370                 375                 380                 


Gly Pro Pro Gly Val Pro Gly Ile Arg Gly Asp Gln Gly Pro Ser Gly 
385                 390                 395                 400 


Leu Ala Gly Lys Pro Gly Val Pro Gly Glu Arg Gly Leu Pro Gly Ala 
                405                 410                 415     


His Gly Pro Pro Gly Pro Thr Gly Pro Lys Gly Glu Pro Gly Phe Thr 
            420                 425                 430         


Gly Arg Pro Gly Gly Pro Gly Val Ala Gly Ala Leu Gly Gln Lys Gly 
        435                 440                 445             


Asp Leu Gly Leu Pro Gly Gln Pro Gly Leu Arg Gly Pro Ser Gly Ile 
    450                 455                 460                 


Pro Gly Leu Gln Gly Pro Ala Gly Pro Ile Gly Pro Gln Gly Leu Pro 
465                 470                 475                 480 


Gly Leu Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Glu Gly Arg 
                485                 490                 495     


Ala Gly Glu Pro Gly Thr Ala Gly Pro Thr Gly Pro Pro Gly Val Pro 
            500                 505                 510         


Gly Ser Pro Gly Ile Thr Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
        515                 520                 525             


Pro Pro Gly Ala Pro Gly Ala Phe Asp Glu Thr Gly Ile Ala Gly Leu 
    530                 535                 540                 


His Leu Pro Asn Gly Gly Val Glu Gly Ala Val Leu Gly Lys Gly Gly 
545                 550                 555                 560 


Lys Pro Gln Phe Gly Leu Gly Glu Leu Ser Ala His Ala Thr Pro Ala 
                565                 570                 575     


Phe Thr Ala Val Leu Thr Ser Pro Phe Pro Ala Ser Gly Met Pro Val 
            580                 585                 590         


Lys Phe Asp Arg Thr Leu Tyr Asn Gly His Ser Gly Tyr Asn Pro Ala 
        595                 600                 605             


Thr Gly Ile Phe Thr Cys Pro Val Gly Gly Val Tyr Tyr Phe Ala Tyr 
    610                 615                 620                 


His Val His Val Lys Gly Thr Asn Val Trp Val Ala Leu Tyr Lys Asn 
625                 630                 635                 640 


Asn Val Pro Ala Thr Tyr Thr Tyr Asp Glu Tyr Lys Lys Gly Tyr Leu 
                645                 650                 655     


Asp Gln Ala Ser Gly Gly Ala Val Leu Gln Leu Arg Pro Asn Asp Gln 
            660                 665                 670         


Val Trp Val Gln Met Pro Ser Asp Gln Ala Asn Gly Leu Tyr Ser Thr 
        675                 680                 685             


Glu Tyr Ile His Ser Ser Phe Ser Gly Phe Leu Leu Cys Pro Thr 
    690                 695                 700             


<210>  5985
<211>  2436
<212>  DNA
<213>  Homosapiens

<400>  5985
agtagagaca gggttttgcc atgttggcca ggttggtctc aaacccctga cctcaggtga     60

tccacccgcc ttgccctccc aaagtgctgg gattacaggc atgagtcact gctcctggcc    120

ccagaattct ttatgtgaga aggagtttct gtgattttaa ctgctattgt aatagaaacc    180

agttgattct gaagagtcac ctcttttcct ggaaatattt tggctgtgag ttaagaggaa    240

cattattttc tcccatgctg gtgactttgg aaaggggttg tcatcagtgc aatgaacttg    300

gtctgggact tccttccttc cccatggact gggcccctgg gtcctctgtt gcttctggga    360

ggggccttgg gagtacagtt tactctaggc caggacattc taagacatgt ggaaaccatt    420

ggtcacacct gccagcaaca gagattagtt tgtaaatgtc tgtttcaggt gtttcacagc    480

atctagtgaa tgaccgttgc tcccatacca gattctggtg acctgatctt aggcttgaca    540

gctgtggtgg agacttgggt tggcagaagc ctaccttggt gtgttggaag agtgattgct    600

tagtgcatga ggtgcctttt acagcccatt ttgcagtagt tctggctgca gccctgctgc    660

tttgaccttg caggccaaat ttcctggctc ctccaaaggg gatgatgttc tttccctcca    720

gacacagtta gagggaatcc tgacagttgc atcaaggctg gtccagactc tcaccacgct    780

ttctcttttg tgctgcttgg tcctgactgc cttttgaatc tcttttagag ctctgagctc    840

ttcaccctga cctatggtgc cctggtcacc cagctatgta aggactatga aaatgatgaa    900

gatgtgaata aacagctgga caaaatgggc tttaacattg gagtccggct gattgaagat    960

ttcttggctc ggtcaaatgt tgggaggtgc catgactttc gggaaactgc ggatgtcatt   1020

gccaaggtgg cgttcaagat gtacttgggc atcactccaa gcattactaa ttggagccca   1080

gctggtgatg aattctccct cattttggaa aataacccct tggtggactt tgtggaactt   1140

cctgataacc actcatccct tatttattcc aatctcttgt gtggggtgtt gcggggagct   1200

ttggagatgg tgagtgcaac tctttatctt ctgggacacc cgaaatgcaa tagggacttg   1260

ataagtgttt aaatgaatga aagagagaaa agaaagggct ttggctcacc ccagcgcttt   1320

actgcctgag atggtgatgc tgctgaggta ggatccaagt cggacatctt tacatggtga   1380

tactcctcca taccaggctg gtggaaggtg gtgctgtcag tccccaaagc ccaggaacat   1440

ccattctcag ataggcttat ttggtgacag tctcattctt gggtattctt tgctaagttt   1500

ctccttaagg gttggagcca ttgtcttatg caacagaatg ttggcgctgt caatcttgtc   1560

cttgtgggaa accagccccc cttttttgga tgctgtggat gagtcagtta tgccccatcc   1620

ccactggttc cctagaggct gtggccaggc agctacccct tcgttttccc actgtccccc   1680

aggtccagat ggctgtggag gccaagtttg tccaggacac cctgaaagga gacggtgtga   1740

cagaaatccg gatgagattc atcaggcgga ttgaggacaa tcttccagct ggagaggaat   1800

aaccatccct acaactcgag gatagccatc aggagcactg ttggaatcag caggcctctg   1860

tgctccctct gccctccaga actcagtgac tcttgaacat ggatgttata tattcttata   1920

acctgtttcc attctccatt caaataaaga gcagactgcg atatagtcca tttaccccat   1980

gtgtgcacat tcaggagcga cagtctctgc ccccattccc ttgagagggg ctggatgtaa   2040

tcacctttgg ttggactaga aagagctcaa accattttac attcctgttt gaatttttcc   2100

aaagcaaaac tcactttgac cccattaaga ggcaagcctg gcacatctat ccctgggcct   2160

ttagaaagcc atttgcctca aatggctata gggttgtggg gtggagggag gaagggctgg   2220

gagggagtgg ggaggaattg ctagctgtag tgtgacacat tgtagtgttt gccaggaaag   2280

gagccagtca tgccggaaac actgacttct gggaagccac ccaggtctca ttcctccctg   2340

ctgttggagg caacatctcc tctttttaca gagggtacat ccttttttct tacaaattct   2400

tcaataaaga cacattcttg agtgaaatcc caatca                             2436


<210>  5986
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  5986

Met Gly Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg 
1               5                   10                  15      


Ser Asn Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile 
            20                  25                  30          


Ala Lys Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr 
        35                  40                  45              


Asn Trp Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn 
    50                  55                  60                  


Pro Leu Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ser Leu Ile 
65                  70                  75                  80  


Tyr Ser Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val 
                85                  90                  95      


Ser Ala Thr Leu Tyr Leu Leu Gly His Pro Lys Cys Asn Arg Asp Leu 
            100                 105                 110         


Ile Ser Val 
        115 


<210>  5987
<211>  1349
<212>  DNA
<213>  Homosapiens

<400>  5987
cttgtgggct gaggggcagc ggcttaggct ccggcgtctg caggggtcgc cgagctaacc     60

cgtggctagg cgagtggggc ggggcggccg gcaccatgtc gaggcaggcg aaccgtggca    120

ccgagagcaa gaaaatggta acttggagcg cgtgacctcg gcgggcgggg cgaaattgag    180

gcgtacaggg aaggggcccg gcgccgagcg cgagagctct gagctcttca ccctgaccta    240

tggtgccctg gtcacccagc tatgtaagga ctatgaaaat gatgaagatg tgaataaaca    300

gctggacaaa atgggcttta acattggagt ccggctgatt gaagatttct tggctcggtc    360

aaatgttggg aggtgccatg actttcggga aactgcggat gtcattgcca aggtggcgtt    420

caagatgtac ttgggcatca ctccaagcat tactaattgg agcccagctg gtgatgaatt    480

ctccctcatt ttggaaaata accccttggt ggactttgtg gaacttcctg ataaccactc    540

atcccttatt tattccaatc tcttgtgtgg ggtgttgcgg ggagctttgg agatggtcca    600

gatggctgtg gaggccaagt ttgtccagga caccctgaaa ggagacggtg tgacagaaat    660

ccggatgaga ttcatcaggc ggattgagga caatcttcca gctggagagg aataaccatc    720

cctacaactc gaggatagcc atcaggagca ctgttggaat cagcaggcct ctgtgctccc    780

tctgccctcc agaactcagt gactcttgaa catggatgtt atatattctt ataacctgtt    840

tccattctcc attcaaataa agagcagact gcgatatagt ccatttaccc catgtgtgca    900

cattcaggag cgacagtctc tgcccccatt cccttgagag gggctggatg taatcacctt    960

tggttggact agaaagagct caaaccattt tacattcctg tttgaatttt tccaaagcaa   1020

aactcacttt gaccccatta agaggcaagc ctggcacatc tatccctggg cctttagaaa   1080

gccatttgcc tcaaatggct atagggttgt ggggtggagg gaggaagggc tgggagggag   1140

tggggaggaa ttgctagctg tagtgtgaca cattgtagtg tttgccagga aaggagccag   1200

tcatgccgga aacactgact tctgggaagc cacccaggtc tcattcctcc ctgctgttgg   1260

aggcaacatc tcctcttttt acagagggta catccttttt tcttacaaat tcttcaataa   1320

agacacattc ttgagtgaaa tcccaatca                                     1349


<210>  5988
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  5988

Met Gly Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg 
1               5                   10                  15      


Ser Asn Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile 
            20                  25                  30          


Ala Lys Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr 
        35                  40                  45              


Asn Trp Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn 
    50                  55                  60                  


Pro Leu Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ser Leu Ile 
65                  70                  75                  80  


Tyr Ser Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val 
                85                  90                  95      


Gln Met Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp 
            100                 105                 110         


Gly Val Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn 
        115                 120                 125             


Leu Pro Ala Gly Glu Glu 
    130                 


<210>  5989
<211>  891
<212>  DNA
<213>  Homosapiens

<400>  5989
cttgtgggct gaggggcagc ggcttaggct ccggcgtctg caggggtcgc cgagctaacc     60

cgtggctagg cgagtggggc ggggcggccg gcaccatgtc gaggcaggcg aaccgtggca    120

ccgagagcaa gaaaatggtc cagatggctg tggaggccaa gtttgtccag gacaccctga    180

aaggagacgg tgtgacagaa atccggatga gattcatcag gcggattgag gacaatcttc    240

cagctggaga ggaataacca tccctacaac tcgaggatag ccatcaggag cactgttgga    300

atcagcaggc ctctgtgctc cctctgccct ccagaactca gtgactcttg aacatggatg    360

ttatatattc ttataacctg tttccattct ccattcaaat aaagagcaga ctgcgatata    420

gtccatttac cccatgtgtg cacattcagg agcgacagtc tctgccccca ttcccttgag    480

aggggctgga tgtaatcacc tttggttgga ctagaaagag ctcaaaccat tttacattcc    540

tgtttgaatt tttccaaagc aaaactcact ttgaccccat taagaggcaa gcctggcaca    600

tctatccctg ggcctttaga aagccatttg cctcaaatgg ctatagggtt gtggggtgga    660

gggaggaagg gctgggaggg agtggggagg aattgctagc tgtagtgtga cacattgtag    720

tgtttgccag gaaaggagcc agtcatgccg gaaacactga cttctgggaa gccacccagg    780

tctcattcct ccctgctgtt ggaggcaaca tctcctcttt ttacagaggg tacatccttt    840

tttcttacaa attcttcaat aaagacacat tcttgagtga aatcccaatc a             891


<210>  5990
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  5990

Met Ser Arg Gln Ala Asn Arg Gly Thr Glu Ser Lys Lys Met Val Gln 
1               5                   10                  15      


Met Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp Gly 
            20                  25                  30          


Val Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn Leu 
        35                  40                  45              


Pro Ala Gly Glu Glu 
    50              


<210>  5991
<211>  1541
<212>  DNA
<213>  Homosapiens

<400>  5991
cgcagtgagt cagtgccggt cggtcttgtg ggctgagggg cagcggctta ggctccggcg     60

tctgcagggg tcgccgagct aacccgtggc taggcgagtg gggcggggcg gccggcacca    120

tgtcgaggca ggcgaaccgt ggcaccgaga gcaagaaaat ggtaacttgg agcgcgtgac    180

ctcggcgggc ggggcgaaat tgaggcgtac agggaagggg cccggcgccg agcgcgaggt    240

gcgtttggaa aagggccttc ctgtgagctc tggcaagggg aagcctcttg ctgggtcact    300

ccgggggcgt tccaggcagg tgaggggacc gtcggagaag ttccccggag gagaccccgc    360

ccccaaggcc tgagtgcagc tctgtgctaa gccaacaaca acgacgagct ctgagctctt    420

caccctgacc tatggtgccc tggtcaccca gctatgtaag gactatgaaa atgatgaaga    480

tgtgaataaa cagctggaca aaatgggctt taacattgga gtccggctga ttgaagattt    540

cttggctcgg tcaaatgttg ggaggtgcca tgactttcgg gaaactgcgg atgtcattgc    600

caaggtggcg ttcaagatgt acttgggcat cactccaagc attactaatt ggagcccagc    660

tggtgatgaa ttctccctca ttttggaaaa taaccccttg gtggactttg tggaacttcc    720

tgataaccac tcatccctta tttattccaa tctcttgtgt ggggtgttgc ggggagcttt    780

ggagatggtc cagatggctg tggaggccaa gtttgtccag gacaccctga aaggagacgg    840

tgtgacagaa atccggatga gattcatcag gcggattgag gacaatcttc cagctggaga    900

ggaataacca tccctacaac tcgaggatag ccatcaggag cactgttgga atcagcaggc    960

ctctgtgctc cctctgccct ccagaactca gtgactcttg aacatggatg ttatatattc   1020

ttataacctg tttccattct ccattcaaat aaagagcaga ctgcgatata gtccatttac   1080

cccatgtgtg cacattcagg agcgacagtc tctgccccca ttcccttgag aggggctgga   1140

tgtaatcacc tttggttgga ctagaaagag ctcaaaccat tttacattcc tgtttgaatt   1200

tttccaaagc aaaactcact ttgaccccat taagaggcaa gcctggcaca tctatccctg   1260

ggcctttaga aagccatttg cctcaaatgg ctatagggtt gtggggtgga gggaggaagg   1320

gctgggaggg agtggggagg aattgctagc tgtagtgtga cacattgtag tgtttgccag   1380

gaaaggagcc agtcatgccg gaaacactga cttctgggaa gccacccagg tctcattcct   1440

ccctgctgtt ggaggcaaca tctcctcttt ttacagaggg tacatccttt tttcttacaa   1500

attcttcaat aaagacacat tcttgagtga aatcccaatc a                       1541


<210>  5992
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  5992

Met Gly Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg 
1               5                   10                  15      


Ser Asn Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile 
            20                  25                  30          


Ala Lys Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr 
        35                  40                  45              


Asn Trp Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn 
    50                  55                  60                  


Pro Leu Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ser Leu Ile 
65                  70                  75                  80  


Tyr Ser Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val 
                85                  90                  95      


Gln Met Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp 
            100                 105                 110         


Gly Val Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn 
        115                 120                 125             


Leu Pro Ala Gly Glu Glu 
    130                 


<210>  5993
<211>  1314
<212>  DNA
<213>  Homosapiens

<400>  5993
cgcgggaggc cgcgcaggcg cagtgagtca gtgccggtcg gtcttgtggg ctgaggggca     60

gcggcttagg ctccggcgtc tgcaggggtc gccgagctaa cccgtggcta ggcgagtggg    120

gcggggcggc cggcaccatg tcgaggcagg cgaaccgtgg caccgagagc aagaaaatga    180

gctctgagct cttcaccctg acctatggtg ccctggtcac ccagctatgt aaggactatg    240

aaaatgatga agatgtgaat aaacagctgg acaaaatggg ctttaacatt ggagtccggc    300

tgattgaaga tttcttggct cggtcaaatg ttgggaggtg ccatgacttt cgggaaactg    360

cggatgtcat tgccaaggtg gcgttcaaga tgtacttggg catcactcca agcattacta    420

attggagccc agctggtgat gaattctccc tcattttgga aaataacccc ttggtggact    480

ttgtggaact tcctgataac cactcatccc ttatttattc caatctcttg tgtggggtgt    540

tgcggggagc tttggagatg gtccagatgg ctgtggaggc caagtttgtc caggacaccc    600

tgaaaggaga cggtgtgaca gaaatccgga tgagattcat caggcggatt gaggacaatc    660

ttccagctgg agaggaataa ccatccctac aactcgagga tagccatcag gagcactgtt    720

ggaatcagca ggcctctgtg ctccctctgc cctccagaac tcagtgactc ttgaacatgg    780

atgttatata ttcttataac ctgtttccat tctccattca aataaagagc agactgcgat    840

atagtccatt taccccatgt gtgcacattc aggagcgaca gtctctgccc ccattccctt    900

gagaggggct ggatgtaatc acctttggtt ggactagaaa gagctcaaac cattttacat    960

tcctgtttga atttttccaa agcaaaactc actttgaccc cattaagagg caagcctggc   1020

acatctatcc ctgggccttt agaaagccat ttgcctcaaa tggctatagg gttgtggggt   1080

ggagggagga agggctggga gggagtgggg aggaattgct agctgtagtg tgacacattg   1140

tagtgtttgc caggaaagga gccagtcatg ccggaaacac tgacttctgg gaagccaccc   1200

aggtctcatt cctccctgct gttggaggca acatctcctc tttttacaga gggtacatcc   1260

ttttttctta caaattcttc aataaagaca cattcttgag tgaaatccca atca         1314


<210>  5994
<211>  180
<212>  PRT
<213>  Homosapiens

<400>  5994

Met Ser Arg Gln Ala Asn Arg Gly Thr Glu Ser Lys Lys Met Ser Ser 
1               5                   10                  15      


Glu Leu Phe Thr Leu Thr Tyr Gly Ala Leu Val Thr Gln Leu Cys Lys 
            20                  25                  30          


Asp Tyr Glu Asn Asp Glu Asp Val Asn Lys Gln Leu Asp Lys Met Gly 
        35                  40                  45              


Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg Ser Asn 
    50                  55                  60                  


Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile Ala Lys 
65                  70                  75                  80  


Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr Asn Trp 
                85                  90                  95      


Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn Pro Leu 
            100                 105                 110         


Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ser Leu Ile Tyr Ser 
        115                 120                 125             


Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val Gln Met 
    130                 135                 140                 


Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp Gly Val 
145                 150                 155                 160 


Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn Leu Pro 
                165                 170                 175     


Ala Gly Glu Glu 
            180 


<210>  5995
<211>  1306
<212>  DNA
<213>  Homosapiens

<400>  5995
cgccgtccgc gccgttcgcg ccgcccccgc cccggagccc cgcgcccgca gcctcccggc     60

gcctctccca cggccacggc cgagcgggct ccacggctcc aggagttcgc cgcgctagct    120

gcctccccct gcgtccgcgt cttggtacgc gccgcagcgc ctgaggacta aagctctgag    180

ctcttcaccc tgacctatgg tgccctggtc acccagctat gtaaggacta tgaaaatgat    240

gaagatgtga ataaacagct ggacaaaatg ggctttaaca ttggagtccg gctgattgaa    300

gatttcttgg ctcggtcaaa tgttgggagg tgccatgact ttcgggaaac tgcggatgtc    360

attgccaagg tggcgttcaa gatgtacttg ggcatcactc caagcattac taattggagc    420

ccagctggtg atgaattctc cctcattttg gaaaataacc ccttggtgga ctttgtggaa    480

cttcctgata accactcatc ccttatttat tccaatctct tgtgtggggt gttgcgggga    540

gctttggaga tggtccagat ggctgtggag gccaagtttg tccaggacac cctgaaagga    600

gacggtgtga cagaaatccg gatgagattc atcaggcgga ttgaggacaa tcttccagct    660

ggagaggaat aaccatccct acaactcgag gatagccatc aggagcactg ttggaatcag    720

caggcctctg tgctccctct gccctccaga actcagtgac tcttgaacat ggatgttata    780

tattcttata acctgtttcc attctccatt caaataaaga gcagactgcg atatagtcca    840

tttaccccat gtgtgcacat tcaggagcga cagtctctgc ccccattccc ttgagagggg    900

ctggatgtaa tcacctttgg ttggactaga aagagctcaa accattttac attcctgttt    960

gaatttttcc aaagcaaaac tcactttgac cccattaaga ggcaagcctg gcacatctat   1020

ccctgggcct ttagaaagcc atttgcctca aatggctata gggttgtggg gtggagggag   1080

gaagggctgg gagggagtgg ggaggaattg ctagctgtag tgtgacacat tgtagtgttt   1140

gccaggaaag gagccagtca tgccggaaac actgacttct gggaagccac ccaggtctca   1200

ttcctccctg ctgttggagg caacatctcc tctttttaca gagggtacat ccttttttct   1260

tacaaattct tcaataaaga cacattcttg agtgaaatcc caatca                  1306


<210>  5996
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  5996

Met Gly Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg 
1               5                   10                  15      


Ser Asn Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile 
            20                  25                  30          


Ala Lys Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr 
        35                  40                  45              


Asn Trp Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn 
    50                  55                  60                  


Pro Leu Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ser Leu Ile 
65                  70                  75                  80  


Tyr Ser Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val 
                85                  90                  95      


Gln Met Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp 
            100                 105                 110         


Gly Val Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn 
        115                 120                 125             


Leu Pro Ala Gly Glu Glu 
    130                 


<210>  5997
<211>  707
<212>  DNA
<213>  Homosapiens

<400>  5997
gttccctaga ggctgtggcc aggcagctac cccttcgttt tcccactgtc ccccaggtcc     60

agatggctgt ggaggccaag tttgtccagg acaccctgaa aggagacggt gtgacagaaa    120

tccggatgag attcatcagg cggattgagg acaatcttcc agctggagag gaataaccat    180

ccctacaact cgaggatagc catcaggagc actgttggaa tcagcaggcc tctgtgctcc    240

ctctgccctc cagaactcag tgactcttga acatggatgt tatatattct tataacctgt    300

ttccattctc cattcaaata aagagcagac tgcgatatag tccatttacc ccatgtgtgc    360

acattcagga gcgacagtct ctgcccccat tcccttgaga ggggctggat gtaatcacct    420

ttggttggac tagaaagagc tcaaaccatt ttacattcct gtttgaattt ttccaaagca    480

aaactcactt tgaccccatt aagaggcaag cctggcacat ctatccctgg gcctttagaa    540

agccatttgc ctcaaatggc tatagggttg tggggtggag ggaggaaggg ctgggaggga    600

gtggggagga attgctagct gtagtgcaac atctcctctt tttacagagg gtacatcctt    660

ttttcttaca aattcttcaa taaagacaca ttcttgagtg aaatccc                  707


<210>  5998
<211>  41
<212>  PRT
<213>  Homosapiens

<400>  5998

Met Asp Val Ile Tyr Ser Tyr Asn Leu Phe Pro Phe Ser Ile Gln Ile 
1               5                   10                  15      


Lys Ser Arg Leu Arg Tyr Ser Pro Phe Thr Pro Cys Val His Ile Gln 
            20                  25                  30          


Glu Arg Gln Ser Leu Pro Pro Phe Pro 
        35                  40      


<210>  5999
<211>  886
<212>  DNA
<213>  Homosapiens

<400>  5999
cttgtgggct gaggggcagc ggcttaggct ccggcgtctg caggggtcgc cgagctaacc     60

cgtggctagg cgagtggggc ggggcggccg gcaccatgtc gaggcaggcg aaccgtggca    120

ccgagagcaa gaaaatggta acttggagcg cgtgacctcg gcgggcgggg cgaaattgag    180

gcgtacaggg aaggggcccg gcgccgagcg cgagagctct gagctcttca ccctgaccta    240

tggtgccctg gtcacccagc tatgtaagga ctatgaaaat gatgaagatg tgaataaaca    300

gctggacaaa atgggcttta acattggagt ccggctgatt gaagatttct tggctcggtc    360

aaatgttggg aggtgccatg actttcggga aactgcggat gtcattgcca aggtggcgtt    420

caagatgtac ttgggcatca ctccaagcat tactaattgg agcccagctg gtgatgaatt    480

ctccctcatt ttggaaaata accccttggt ggactttgtg gaacttcctg ataaccactc    540

atcccttatt tattccaatc tcttgtgtgg ggtgttgcgg ggagctttgg agatggtcca    600

gatggctgtg gaggccaagt ttgtccagga caccctgaaa ggagacggtg tgacagaaat    660

ccggatgaga ttcatcaggc ggattgagga caatcttcca gctggagagg aataaccatc    720

cctacaactc gaggatagcc atcaggagca ctgttggaat cagcaggcct ctgtgctccc    780

tctgccctcc agaactcagt gactcttgaa catggatgtt atatattctt ataacctgtt    840

tccattctcc attcaaataa agagcagact gcgatatagt ccattt                   886


<210>  6000
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  6000

Met Gly Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg 
1               5                   10                  15      


Ser Asn Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile 
            20                  25                  30          


Ala Lys Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr 
        35                  40                  45              


Asn Trp Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn 
    50                  55                  60                  


Pro Leu Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ser Leu Ile 
65                  70                  75                  80  


Tyr Ser Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val 
                85                  90                  95      


Gln Met Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp 
            100                 105                 110         


Gly Val Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn 
        115                 120                 125             


Leu Pro Ala Gly Glu Glu 
    130                 


<210>  6001
<211>  428
<212>  DNA
<213>  Homosapiens

<400>  6001
cttgtgggct gaggggcagc ggcttaggct ccggcgtctg caggggtcgc cgagctaacc     60

cgtggctagg cgagtggggc ggggcggccg gcaccatgtc gaggcaggcg aaccgtggca    120

ccgagagcaa gaaaatggtc cagatggctg tggaggccaa gtttgtccag gacaccctga    180

aaggagacgg tgtgacagaa atccggatga gattcatcag gcggattgag gacaatcttc    240

cagctggaga ggaataacca tccctacaac tcgaggatag ccatcaggag cactgttgga    300

atcagcaggc ctctgtgctc cctctgccct ccagaactca gtgactcttg aacatggatg    360

ttatatattc ttataacctg tttccattct ccattcaaat aaagagcaga ctgcgatata    420

gtccattt                                                             428


<210>  6002
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6002

Met Ser Arg Gln Ala Asn Arg Gly Thr Glu Ser Lys Lys Met Val Gln 
1               5                   10                  15      


Met Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp Gly 
            20                  25                  30          


Val Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn Leu 
        35                  40                  45              


Pro Ala Gly Glu Glu 
    50              


<210>  6003
<211>  1078
<212>  DNA
<213>  Homosapiens

<400>  6003
cgcagtgagt cagtgccggt cggtcttgtg ggctgagggg cagcggctta ggctccggcg     60

tctgcagggg tcgccgagct aacccgtggc taggcgagtg gggcggggcg gccggcacca    120

tgtcgaggca ggcgaaccgt ggcaccgaga gcaagaaaat ggtaacttgg agcgcgtgac    180

ctcggcgggc ggggcgaaat tgaggcgtac agggaagggg cccggcgccg agcgcgaggt    240

gcgtttggaa aagggccttc ctgtgagctc tggcaagggg aagcctcttg ctgggtcact    300

ccgggggcgt tccaggcagg tgaggggacc gtcggagaag ttccccggag gagaccccgc    360

ccccaaggcc tgagtgcagc tctgtgctaa gccaacaaca acgacgagct ctgagctctt    420

caccctgacc tatggtgccc tggtcaccca gctatgtaag gactatgaaa atgatgaaga    480

tgtgaataaa cagctggaca aaatgggctt taacattgga gtccggctga ttgaagattt    540

cttggctcgg tcaaatgttg ggaggtgcca tgactttcgg gaaactgcgg atgtcattgc    600

caaggtggcg ttcaagatgt acttgggcat cactccaagc attactaatt ggagcccagc    660

tggtgatgaa ttctccctca ttttggaaaa taaccccttg gtggactttg tggaacttcc    720

tgataaccac tcatccctta tttattccaa tctcttgtgt ggggtgttgc ggggagcttt    780

ggagatggtc cagatggctg tggaggccaa gtttgtccag gacaccctga aaggagacgg    840

tgtgacagaa atccggatga gattcatcag gcggattgag gacaatcttc cagctggaga    900

ggaataacca tccctacaac tcgaggatag ccatcaggag cactgttgga atcagcaggc    960

ctctgtgctc cctctgccct ccagaactca gtgactcttg aacatggatg ttatatattc   1020

ttataacctg tttccattct ccattcaaat aaagagcaga ctgcgatata gtccattt     1078


<210>  6004
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  6004

Met Gly Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg 
1               5                   10                  15      


Ser Asn Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile 
            20                  25                  30          


Ala Lys Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr 
        35                  40                  45              


Asn Trp Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn 
    50                  55                  60                  


Pro Leu Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ser Leu Ile 
65                  70                  75                  80  


Tyr Ser Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val 
                85                  90                  95      


Gln Met Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp 
            100                 105                 110         


Gly Val Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn 
        115                 120                 125             


Leu Pro Ala Gly Glu Glu 
    130                 


<210>  6005
<211>  851
<212>  DNA
<213>  Homosapiens

<400>  6005
cgcgggaggc cgcgcaggcg cagtgagtca gtgccggtcg gtcttgtggg ctgaggggca     60

gcggcttagg ctccggcgtc tgcaggggtc gccgagctaa cccgtggcta ggcgagtggg    120

gcggggcggc cggcaccatg tcgaggcagg cgaaccgtgg caccgagagc aagaaaatga    180

gctctgagct cttcaccctg acctatggtg ccctggtcac ccagctatgt aaggactatg    240

aaaatgatga agatgtgaat aaacagctgg acaaaatggg ctttaacatt ggagtccggc    300

tgattgaaga tttcttggct cggtcaaatg ttgggaggtg ccatgacttt cgggaaactg    360

cggatgtcat tgccaaggtg gcgttcaaga tgtacttggg catcactcca agcattacta    420

attggagccc agctggtgat gaattctccc tcattttgga aaataacccc ttggtggact    480

ttgtggaact tcctgataac cactcatccc ttatttattc caatctcttg tgtggggtgt    540

tgcggggagc tttggagatg gtccagatgg ctgtggaggc caagtttgtc caggacaccc    600

tgaaaggaga cggtgtgaca gaaatccgga tgagattcat caggcggatt gaggacaatc    660

ttccagctgg agaggaataa ccatccctac aactcgagga tagccatcag gagcactgtt    720

ggaatcagca ggcctctgtg ctccctctgc cctccagaac tcagtgactc ttgaacatgg    780

atgttatata ttcttataac ctgtttccat tctccattca aataaagagc agactgcgat    840

atagtccatt t                                                         851


<210>  6006
<211>  180
<212>  PRT
<213>  Homosapiens

<400>  6006

Met Ser Arg Gln Ala Asn Arg Gly Thr Glu Ser Lys Lys Met Ser Ser 
1               5                   10                  15      


Glu Leu Phe Thr Leu Thr Tyr Gly Ala Leu Val Thr Gln Leu Cys Lys 
            20                  25                  30          


Asp Tyr Glu Asn Asp Glu Asp Val Asn Lys Gln Leu Asp Lys Met Gly 
        35                  40                  45              


Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg Ser Asn 
    50                  55                  60                  


Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile Ala Lys 
65                  70                  75                  80  


Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr Asn Trp 
                85                  90                  95      


Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn Pro Leu 
            100                 105                 110         


Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ser Leu Ile Tyr Ser 
        115                 120                 125             


Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val Gln Met 
    130                 135                 140                 


Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp Gly Val 
145                 150                 155                 160 


Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn Leu Pro 
                165                 170                 175     


Ala Gly Glu Glu 
            180 


<210>  6007
<211>  599
<212>  DNA
<213>  Homosapiens

<400>  6007
caacgacggt aataaatacc aataactgcc acttaacttc tctcttacta tgtgttgggc     60

accgggccac gcacgttaca gcatctcagt taatctgcag agtagcccct atcagatgga    120

taacattgcc gttttacagc ttggagagct tacgtaattt gcccatattt acacctggga    180

agttaggatt tggacccgtg tttaactcca aagctaatgc taggagctga ctgttaggct    240

ttactcttag gctacagtgt ctcgtactgt ggcgtgggta ttgtgagaga tgttcagata    300

ctggtcgtgc cagaaaggaa cgttttattc aatggaataa gagatgggcc agagtaagca    360

gtgagtggtg cccctctaat ggagtgggtg gctcccttct ttcccaggga atagtttgga    420

caccatatgg tcctataaag ttggactagg ggctggggct gcagacttag gtcatttttc    480

tttcgttctt ccctccctcc ccccgccccc agacgaaatc tctgtcaccc ggggtggagt    540

gcatgagccg agatcacatc actgcattcc atcctgggta acagagcaag actccatct     599


<210>  6008
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  6008

Met Cys Trp Ala Pro Gly His Ala Arg Tyr Ser Ile Ser Val Asn Leu 
1               5                   10                  15      


Gln Ser Ser Pro Tyr Gln Met Asp Asn Ile Ala Val Leu Gln Leu Gly 
            20                  25                  30          


Glu Leu Thr 
        35  


<210>  6009
<211>  711
<212>  DNA
<213>  Homosapiens

<400>  6009
agggaagggg cccggcgccg agcgcgaggt gcgtttggaa aagggccttc ctgtgagctc     60

tggcaagggg aagcctcttg ctgggtcact ccgggggcgt tccaggcagg tgaggggacc    120

gtcggagaag ttccccggag gagaccccgc ccccaaggcc tgagtgcagc tctgtgctaa    180

gccaacaaca acgacgagct ctgagctctt caccctgacc tatggtgccc tggtcaccca    240

gctatgtaag gactatgaaa atgatgaaga tgtgaataaa cagctggaca aaatgggctt    300

taacattgga gtccggctga ttgaagattt cttggctcgg tcaaatgttg ggaggtgcca    360

tgactttcgg gaaactgcgg atgtcattgc caaggtcatt attctgggcc acctgtccat    420

gctgaagaat tgctgctgag aggcactgct taccactctt tctatctccc ttagagaggc    480

ctttaatctc ccaaaagact ggctaggcag ctctttgggt caaaaaaaca ttccaggtcg    540

ttagggaata gcatagatta tttaatccct gtggattaaa gccccactga aatcaaagcc    600

tgagcttttc cactgtgaag gtgtagcaga gtagcatggg ggtaaagaat acagactcgg    660

tcgggcgtgg tggctcacat ctgtaatcct agcactttgg gaggcccagg c             711


<210>  6010
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  6010

Met Gly Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg 
1               5                   10                  15      


Ser Asn Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile 
            20                  25                  30          


Ala Lys Val Ile Ile Leu Gly His Leu Ser Met Leu Lys Asn Cys Cys 
        35                  40                  45              


<210>  6011
<211>  3113
<212>  DNA
<213>  Homosapiens

<400>  6011
ccggagcaag ggcggcagca aggctcccag acctgtcccc agcccagcca tcagcagggg     60

agagaaagcg aaaccctttc aggggtctcc ttgtgactct ccttcatgcc tcccgacgtc    120

ccccgggccg ctttggttta gctgtggtcg ccaggacccc cccagagcca agaccttctc    180

cagaaggtga cccttccccc ccaccaccac caatgtcagc cctggtcccc gacactcccc    240

cggacacccc tcctgccatg aagaatgcca ctagctctaa gcagctccca ctggaaccag    300

agagcccctc agggcaggtc gggcctaggc cagccccccc gcaggaagag tccccttcct    360

ctgaagcaaa gagcagagga cccaccccac cagccatggg cccacgggat gccagacctc    420

ctcgaaggag cagccagcca tctccaacag cagtgccagc ctccgacagc cctcccacca    480

agcaagaggt gaagaaggca ggagagagac acaagctggc aaaggagcgg cgagaagagc    540

gggccaagta cctggcggcc aagaaggcag tgtggctgga gaaggaggag aaggccaagg    600

cgctgcggga gaagcagctc caggagcgcc ggcgccggct ggaggagcaa cgtcttaaag    660

ccgagcaacg ccgtgcagcc ctggaggaac ggcagcggca gaagctcgag aaaaacaagg    720

agcgctatga agcagccatc caacggtcag tgaagaagac gtgggccgaa atccggcagc    780

agcgctggtc ctgggcaggg gccctgcacc acagctctcc aggacataag accagtggga    840

gcaggtgctc cgtgtcggca gttaacctgc ccaaacacgt ggactctata atcaacaagc    900

ggctctcaaa gtcctctgcc acgctctgga actcccccag tagaaatcgc agcctgcagc    960

tgagcgcatg ggagagcagc atcgtggatc gtctgatgac gcccactctc tccttccttg   1020

ctcggagtcg cagcgcggtc acactgcccc gcaacggccg ggaccaggcc gtgccggtgt   1080

gcccgcgctc ggcctccgcc agccccctga cgccgtgcag cgtcacccga agcgtgcacc   1140

gctgcgcccc cgccggtgag cgcggggagc gccgcaagcc caacgccggg ggcagccccg   1200

ctccggtgcg ccgccggccg gaggcctcgc cggtgcagaa aaaggagaag aaggacaagg   1260

agcgggaaaa cgagaaggag aagagtgccc tagcccggga gcgcagcctc aagaagcgcc   1320

agtcgctgcc cgcctcccca cgtgcccgcc tctctgccag caccgcctct gagctcagcc   1380

ccaaatccaa ggccaggcca tcctctccct ccacatcctg gcacaggcct gcctccccct   1440

gccccagccc agggccaggc cacactctgc ctccaaagcc accgtccccc cgaggcacca   1500

ctgcatcccc caaggggcgg gttcggagga aggaggaggc aaaggagagc cccagcgccg   1560

cagggcccga ggacaagagc cagagcaagc gcagggccag taacgagaag gagtcagcag   1620

ccccagcctc accggcacct tcgccggcgc cctcgcccac cccagccccg ccccagaagg   1680

agcagccccc cgcggagacc cctacagacg ctgctgtctt gacctcaccc ccagcccctg   1740

ctcccccggt gacccctagc aaaccaatgg ccggcaccac agaccgagaa gaagccactc   1800

ggctcttggc tgagaagcgg cgccaggccc gggagcagcg ggagcgcgag gagcaggagc   1860

ggaggctgca ggcagaaagg gacaagcgaa tgcgagagga gcagctggca cgggaggccg   1920

aggcccgggc ggagcgggag gcggaggccc ggaggcggga ggagcaggag gcacgagaga   1980

aggcgcaggc cgagcaggag gagcaggagc ggctgcagaa gcagaaagag gaggccgaag   2040

ctcggtcgcg ggaagaggcg gagcggcagc gtctggagcg ggaaaagcac ttccagcagc   2100

aggagcaaga gcggcaagag cgcagaaagc gtctggagga gatcatgaag aggactcgga   2160

agtcagaagt ttctgaaacc aagaagcagg acagcaagga ggccaacgcc aacggttcca   2220

gcccagagcc tgtgaaagct gtggaggctc ggtccccagg gctgcagaag gaggctgtgc   2280

agaaagagga gcccatccca caggagcctc agtggagtct cccaagcaag gagttgccag   2340

cgtccctggt gaatggcctg cagcctctcc cagcacacca ggagaatggc ttctccacca   2400

acggaccctc tggggacaag agtctgagcc gaacaccaga gacactcctg ccctttgcag   2460

aggcagaagc cttcctcaag aaagctgtgg tgcagtcccc gcaggtcaca gaagtccttt   2520

aagagggttt gccttggatc cgggcacagt tgtgagggct cctctgcatc acctaccagg   2580

atgtctggag gagaaaaaga cagaacaaag atggaagtgg cctgggcccc tgggggtggg   2640

tcctctctgt tgtttttaat ctgcacctta tagactgatg tctctttggc cggagccaga   2700

tctgcccctc agtgcattcg tgtgctcgca cgcgcagaca tcccttctcc cccatacaca   2760

catatacact cacagcctct ctggcctctt cccttgggga ggggccacct gtagtatttg   2820

ccttgatttg gtggggtaca gtggatgtga atactgtaaa tagcttgtgc tcagactcct   2880

ctgcgtggag agggtgggtg caggaggcag accctccccc caaagccccc tggggagatc   2940

ttcctctctc tatttaactg taactgaggg ggatcccagg tctggggatg ggggacacct   3000

tgggccacag gatactggtt gcttcagggg tacccatgcc ccctgccctc gcctggaatc   3060

agtgttactg catctgatta aatgtctcca gaaataaaga ataattctgc caa          3113


<210>  6012
<211>  769
<212>  PRT
<213>  Homosapiens

<400>  6012

Met Ser Ala Leu Val Pro Asp Thr Pro Pro Asp Thr Pro Pro Ala Met 
1               5                   10                  15      


Lys Asn Ala Thr Ser Ser Lys Gln Leu Pro Leu Glu Pro Glu Ser Pro 
            20                  25                  30          


Ser Gly Gln Val Gly Pro Arg Pro Ala Pro Pro Gln Glu Glu Ser Pro 
        35                  40                  45              


Ser Ser Glu Ala Lys Ser Arg Gly Pro Thr Pro Pro Ala Met Gly Pro 
    50                  55                  60                  


Arg Asp Ala Arg Pro Pro Arg Arg Ser Ser Gln Pro Ser Pro Thr Ala 
65                  70                  75                  80  


Val Pro Ala Ser Asp Ser Pro Pro Thr Lys Gln Glu Val Lys Lys Ala 
                85                  90                  95      


Gly Glu Arg His Lys Leu Ala Lys Glu Arg Arg Glu Glu Arg Ala Lys 
            100                 105                 110         


Tyr Leu Ala Ala Lys Lys Ala Val Trp Leu Glu Lys Glu Glu Lys Ala 
        115                 120                 125             


Lys Ala Leu Arg Glu Lys Gln Leu Gln Glu Arg Arg Arg Arg Leu Glu 
    130                 135                 140                 


Glu Gln Arg Leu Lys Ala Glu Gln Arg Arg Ala Ala Leu Glu Glu Arg 
145                 150                 155                 160 


Gln Arg Gln Lys Leu Glu Lys Asn Lys Glu Arg Tyr Glu Ala Ala Ile 
                165                 170                 175     


Gln Arg Ser Val Lys Lys Thr Trp Ala Glu Ile Arg Gln Gln Arg Trp 
            180                 185                 190         


Ser Trp Ala Gly Ala Leu His His Ser Ser Pro Gly His Lys Thr Ser 
        195                 200                 205             


Gly Ser Arg Cys Ser Val Ser Ala Val Asn Leu Pro Lys His Val Asp 
    210                 215                 220                 


Ser Ile Ile Asn Lys Arg Leu Ser Lys Ser Ser Ala Thr Leu Trp Asn 
225                 230                 235                 240 


Ser Pro Ser Arg Asn Arg Ser Leu Gln Leu Ser Ala Trp Glu Ser Ser 
                245                 250                 255     


Ile Val Asp Arg Leu Met Thr Pro Thr Leu Ser Phe Leu Ala Arg Ser 
            260                 265                 270         


Arg Ser Ala Val Thr Leu Pro Arg Asn Gly Arg Asp Gln Ala Val Pro 
        275                 280                 285             


Val Cys Pro Arg Ser Ala Ser Ala Ser Pro Leu Thr Pro Cys Ser Val 
    290                 295                 300                 


Thr Arg Ser Val His Arg Cys Ala Pro Ala Gly Glu Arg Gly Glu Arg 
305                 310                 315                 320 


Arg Lys Pro Asn Ala Gly Gly Ser Pro Ala Pro Val Arg Arg Arg Pro 
                325                 330                 335     


Glu Ala Ser Pro Val Gln Lys Lys Glu Lys Lys Asp Lys Glu Arg Glu 
            340                 345                 350         


Asn Glu Lys Glu Lys Ser Ala Leu Ala Arg Glu Arg Ser Leu Lys Lys 
        355                 360                 365             


Arg Gln Ser Leu Pro Ala Ser Pro Arg Ala Arg Leu Ser Ala Ser Thr 
    370                 375                 380                 


Ala Ser Glu Leu Ser Pro Lys Ser Lys Ala Arg Pro Ser Ser Pro Ser 
385                 390                 395                 400 


Thr Ser Trp His Arg Pro Ala Ser Pro Cys Pro Ser Pro Gly Pro Gly 
                405                 410                 415     


His Thr Leu Pro Pro Lys Pro Pro Ser Pro Arg Gly Thr Thr Ala Ser 
            420                 425                 430         


Pro Lys Gly Arg Val Arg Arg Lys Glu Glu Ala Lys Glu Ser Pro Ser 
        435                 440                 445             


Ala Ala Gly Pro Glu Asp Lys Ser Gln Ser Lys Arg Arg Ala Ser Asn 
    450                 455                 460                 


Glu Lys Glu Ser Ala Ala Pro Ala Ser Pro Ala Pro Ser Pro Ala Pro 
465                 470                 475                 480 


Ser Pro Thr Pro Ala Pro Pro Gln Lys Glu Gln Pro Pro Ala Glu Thr 
                485                 490                 495     


Pro Thr Asp Ala Ala Val Leu Thr Ser Pro Pro Ala Pro Ala Pro Pro 
            500                 505                 510         


Val Thr Pro Ser Lys Pro Met Ala Gly Thr Thr Asp Arg Glu Glu Ala 
        515                 520                 525             


Thr Arg Leu Leu Ala Glu Lys Arg Arg Gln Ala Arg Glu Gln Arg Glu 
    530                 535                 540                 


Arg Glu Glu Gln Glu Arg Arg Leu Gln Ala Glu Arg Asp Lys Arg Met 
545                 550                 555                 560 


Arg Glu Glu Gln Leu Ala Arg Glu Ala Glu Ala Arg Ala Glu Arg Glu 
                565                 570                 575     


Ala Glu Ala Arg Arg Arg Glu Glu Gln Glu Ala Arg Glu Lys Ala Gln 
            580                 585                 590         


Ala Glu Gln Glu Glu Gln Glu Arg Leu Gln Lys Gln Lys Glu Glu Ala 
        595                 600                 605             


Glu Ala Arg Ser Arg Glu Glu Ala Glu Arg Gln Arg Leu Glu Arg Glu 
    610                 615                 620                 


Lys His Phe Gln Gln Gln Glu Gln Glu Arg Gln Glu Arg Arg Lys Arg 
625                 630                 635                 640 


Leu Glu Glu Ile Met Lys Arg Thr Arg Lys Ser Glu Val Ser Glu Thr 
                645                 650                 655     


Lys Lys Gln Asp Ser Lys Glu Ala Asn Ala Asn Gly Ser Ser Pro Glu 
            660                 665                 670         


Pro Val Lys Ala Val Glu Ala Arg Ser Pro Gly Leu Gln Lys Glu Ala 
        675                 680                 685             


Val Gln Lys Glu Glu Pro Ile Pro Gln Glu Pro Gln Trp Ser Leu Pro 
    690                 695                 700                 


Ser Lys Glu Leu Pro Ala Ser Leu Val Asn Gly Leu Gln Pro Leu Pro 
705                 710                 715                 720 


Ala His Gln Glu Asn Gly Phe Ser Thr Asn Gly Pro Ser Gly Asp Lys 
                725                 730                 735     


Ser Leu Ser Arg Thr Pro Glu Thr Leu Leu Pro Phe Ala Glu Ala Glu 
            740                 745                 750         


Ala Phe Leu Lys Lys Ala Val Val Gln Ser Pro Gln Val Thr Glu Val 
        755                 760                 765             


Leu 
    


<210>  6013
<211>  3754
<212>  DNA
<213>  Homosapiens

<400>  6013
cttgtgactc tccttcatgc ctcccgacgt cccccgggcc gctttggttt aggtgggttt     60

gagcgagaat ttggactcga agctgccctc tcagccccag tgccagagcc cccaaactcc    120

agggtgggaa aggggagtcc cagccctgct ccccctctcc cccagtcccc gcggcgggtg    180

agtcacccga gcgctcccta cttagtcctc aggcgctgcg gcgcgtacca agacgcggac    240

gcagggggag gcagctagcg cggcgaactc ctggagccgt ggagcccgct cggccgtggc    300

cgtgggagag gcgccgggag gctgcgggcg cggggctccg gggcgggggc ggcgcgaacg    360

gcgcggacgg cgcgggcgcg gggggctggg tcccggggcg ctgctggggt ggaccccccc    420

gcctcgaact tggtacgcgc cagcgagagg ccaggcccag cccgggcggt acaatagggt    480

tgggccgagg ccgggactgg gccggcgccg ggcggggaac gggttcgcga ccgcagccga    540

gagaccccgg gcgaccggca cctccgagac tcgcgggcca cctgcctcga ccttccccgg    600

agcgcccccg cctccgagtc gctacttgcc gggccgggcc gggccgggcg tgatgcgccg    660

cgggacccct gtcctggcca ctggccgccg ccgccgccgc cgctgagacc ccgagacccc    720

cagtgacgcc gcagccatgg agagcggccc gcgtgcggag ctgggggcgg gcgcaccccc    780

agctgtggtc gccaggaccc ccccagagcc aagaccttct ccagaaggtg acccttcccc    840

cccaccacca ccaatgtcag ccctggtccc cgacactccc ccggacaccc ctcctgccat    900

gaagaatgcc actagctcta agcagctccc actggaacca gagagcccct cagggcaggt    960

cgggcctagg ccagcccccc cgcaggaaga gtccccttcc tctgaagcaa agagcagagg   1020

acccacccca ccagccatgg gcccacggga tgccagacct cctcgaagga gcagccagcc   1080

atctccaaca gcagtgccag cctccgacag ccctcccacc aagcaagagg tgaagaaggc   1140

aggagagaga cacaagctgg caaaggagcg gcgagaagag cgggccaagt acctggcggc   1200

caagaaggca gtgtggctgg agaaggagga gaaggccaag gcgctgcggg agaagcagct   1260

ccaggagcgc cggcgccggc tggaggagca acgtcttaaa gccgagcaac gccgtgcagc   1320

cctggaggaa cggcagcggc agaagctcga gaaaaacaag gagcgctatg aagcagccat   1380

ccaacggtca gtgaagaaga cgtgggccga aatccggcag cagcgctggt cctgggcagg   1440

ggccctgcac cacagctctc caggacataa gaccagtggg agcaggtgct ccgtgtcggc   1500

agttaacctg cccaaacacg tggactctat aatcaacaag cggctctcaa agtcctctgc   1560

cacgctctgg aactccccca gtagaaatcg cagcctgcag ctgagcgcat gggagagcag   1620

catcgtggat cgtctgatga cgcccactct ctccttcctt gctcggagtc gcagcgcggt   1680

cacactgccc cgcaacggcc gggaccaggc cgtgccggtg tgcccgcgct cggcctccgc   1740

cagccccctg acgccgtgca gcgtcacccg aagcgtgcac cgctgcgccc ccgccggtga   1800

gcgcggggag cgccgcaagc ccaacgccgg gggcagcccc gctccggtgc gccgccggcc   1860

ggaggcctcg ccggtgcaga aaaaggagaa gaaggacaag gagcgggaaa acgagaagga   1920

gaagagtgcc ctagcccggg agcgcagcct caagaagcgc cagtcgctgc ccgcctcccc   1980

acgtgcccgc ctctctgcca gcaccgcctc tgagctcagc cccaaatcca aggccaggcc   2040

atcctctccc tccacatcct ggcacaggcc tgcctccccc tgccccagcc cagggccagg   2100

ccacactctg cctccaaagc caccgtcccc ccgaggcacc actgcatccc ccaaggggcg   2160

ggttcggagg aaggaggagg caaaggagag ccccagcgcc gcagggcccg aggacaagag   2220

ccagagcaag cgcagggcca gtaacgagaa ggagtcagca gccccagcct caccggcacc   2280

ttcgccggcg ccctcgccca ccccagcccc gccccagaag gagcagcccc ccgcggagac   2340

ccctacagac gctgctgtct tgacctcacc cccagcccct gctcccccgg tgacccctag   2400

caaaccaatg gccggcacca cagaccgaga agaagccact cggctcttgg ctgagaagcg   2460

gcgccaggcc cgggagcagc gggagcgcga ggagcaggag cggaggctgc aggcagaaag   2520

ggacaagcga atgcgagagg agcagctggc acgggaggcc gaggcccggg cggagcggga   2580

ggcggaggcc cggaggcggg aggagcagga ggcacgagag aaggcgcagg ccgagcagga   2640

ggagcaggag cggctgcaga agcagaaaga ggaggccgaa gctcggtcgc gggaagaggc   2700

ggagcggcag cgtctggagc gggaaaagca cttccagcag caggagcaag agcggcaaga   2760

gcgcagaaag cgtctggagg agatcatgaa gaggactcgg aagtcagaag tttctgaaac   2820

caagaagcag gacagcaagg aggccaacgc caacggttcc agcccagagc ctgtgaaagc   2880

tgtggaggct cggtccccag ggctgcagaa ggaggctgtg cagaaagagg agcccatccc   2940

acaggagcct cagtggagtc tcccaagcaa ggagttgcca gcgtccctgg tgaatggcct   3000

gcagcctctc ccagcacacc aggagaatgg cttctccacc aacggaccct ctggggacaa   3060

gagtctgagc cgaacaccag agacactcct gccctttgca gaggcagaag ccttcctcaa   3120

gaaagctgtg gtgcagtccc cgcaggtcac agaagtcctt taagagggtt tgccttggat   3180

ccgggcacag ttgtgagggc tcctctgcat cacctaccag gatgtctgga ggagaaaaag   3240

acagaacaaa gatggaagtg gcctgggccc ctgggggtgg gtcctctctg ttgtttttaa   3300

tctgcacctt atagactgat gtctctttgg ccggagccag atctgcccct cagtgcattc   3360

gtgtgctcgc acgcgcagac atcccttctc ccccatacac acatatacac tcacagcctc   3420

tctggcctct tcccttgggg aggggccacc tgtagtattt gccttgattt ggtggggtac   3480

agtggatgtg aatactgtaa atagcttgtg ctcagactcc tctgcgtgga gagggtgggt   3540

gcaggaggca gaccctcccc ccaaagcccc ctggggagat cttcctctct ctatttaact   3600

gtaactgagg gggatcccag gtctggggat gggggacacc ttgggccaca ggatactggt   3660

tgcttcaggg gtacccatgc cccctgccct cgcctggaat cagtgttact gcatctgatt   3720

aaatgtctcc agaaataaag aataattctg ccaa                               3754


<210>  6014
<211>  808
<212>  PRT
<213>  Homosapiens

<400>  6014

Met Glu Ser Gly Pro Arg Ala Glu Leu Gly Ala Gly Ala Pro Pro Ala 
1               5                   10                  15      


Val Val Ala Arg Thr Pro Pro Glu Pro Arg Pro Ser Pro Glu Gly Asp 
            20                  25                  30          


Pro Ser Pro Pro Pro Pro Pro Met Ser Ala Leu Val Pro Asp Thr Pro 
        35                  40                  45              


Pro Asp Thr Pro Pro Ala Met Lys Asn Ala Thr Ser Ser Lys Gln Leu 
    50                  55                  60                  


Pro Leu Glu Pro Glu Ser Pro Ser Gly Gln Val Gly Pro Arg Pro Ala 
65                  70                  75                  80  


Pro Pro Gln Glu Glu Ser Pro Ser Ser Glu Ala Lys Ser Arg Gly Pro 
                85                  90                  95      


Thr Pro Pro Ala Met Gly Pro Arg Asp Ala Arg Pro Pro Arg Arg Ser 
            100                 105                 110         


Ser Gln Pro Ser Pro Thr Ala Val Pro Ala Ser Asp Ser Pro Pro Thr 
        115                 120                 125             


Lys Gln Glu Val Lys Lys Ala Gly Glu Arg His Lys Leu Ala Lys Glu 
    130                 135                 140                 


Arg Arg Glu Glu Arg Ala Lys Tyr Leu Ala Ala Lys Lys Ala Val Trp 
145                 150                 155                 160 


Leu Glu Lys Glu Glu Lys Ala Lys Ala Leu Arg Glu Lys Gln Leu Gln 
                165                 170                 175     


Glu Arg Arg Arg Arg Leu Glu Glu Gln Arg Leu Lys Ala Glu Gln Arg 
            180                 185                 190         


Arg Ala Ala Leu Glu Glu Arg Gln Arg Gln Lys Leu Glu Lys Asn Lys 
        195                 200                 205             


Glu Arg Tyr Glu Ala Ala Ile Gln Arg Ser Val Lys Lys Thr Trp Ala 
    210                 215                 220                 


Glu Ile Arg Gln Gln Arg Trp Ser Trp Ala Gly Ala Leu His His Ser 
225                 230                 235                 240 


Ser Pro Gly His Lys Thr Ser Gly Ser Arg Cys Ser Val Ser Ala Val 
                245                 250                 255     


Asn Leu Pro Lys His Val Asp Ser Ile Ile Asn Lys Arg Leu Ser Lys 
            260                 265                 270         


Ser Ser Ala Thr Leu Trp Asn Ser Pro Ser Arg Asn Arg Ser Leu Gln 
        275                 280                 285             


Leu Ser Ala Trp Glu Ser Ser Ile Val Asp Arg Leu Met Thr Pro Thr 
    290                 295                 300                 


Leu Ser Phe Leu Ala Arg Ser Arg Ser Ala Val Thr Leu Pro Arg Asn 
305                 310                 315                 320 


Gly Arg Asp Gln Ala Val Pro Val Cys Pro Arg Ser Ala Ser Ala Ser 
                325                 330                 335     


Pro Leu Thr Pro Cys Ser Val Thr Arg Ser Val His Arg Cys Ala Pro 
            340                 345                 350         


Ala Gly Glu Arg Gly Glu Arg Arg Lys Pro Asn Ala Gly Gly Ser Pro 
        355                 360                 365             


Ala Pro Val Arg Arg Arg Pro Glu Ala Ser Pro Val Gln Lys Lys Glu 
    370                 375                 380                 


Lys Lys Asp Lys Glu Arg Glu Asn Glu Lys Glu Lys Ser Ala Leu Ala 
385                 390                 395                 400 


Arg Glu Arg Ser Leu Lys Lys Arg Gln Ser Leu Pro Ala Ser Pro Arg 
                405                 410                 415     


Ala Arg Leu Ser Ala Ser Thr Ala Ser Glu Leu Ser Pro Lys Ser Lys 
            420                 425                 430         


Ala Arg Pro Ser Ser Pro Ser Thr Ser Trp His Arg Pro Ala Ser Pro 
        435                 440                 445             


Cys Pro Ser Pro Gly Pro Gly His Thr Leu Pro Pro Lys Pro Pro Ser 
    450                 455                 460                 


Pro Arg Gly Thr Thr Ala Ser Pro Lys Gly Arg Val Arg Arg Lys Glu 
465                 470                 475                 480 


Glu Ala Lys Glu Ser Pro Ser Ala Ala Gly Pro Glu Asp Lys Ser Gln 
                485                 490                 495     


Ser Lys Arg Arg Ala Ser Asn Glu Lys Glu Ser Ala Ala Pro Ala Ser 
            500                 505                 510         


Pro Ala Pro Ser Pro Ala Pro Ser Pro Thr Pro Ala Pro Pro Gln Lys 
        515                 520                 525             


Glu Gln Pro Pro Ala Glu Thr Pro Thr Asp Ala Ala Val Leu Thr Ser 
    530                 535                 540                 


Pro Pro Ala Pro Ala Pro Pro Val Thr Pro Ser Lys Pro Met Ala Gly 
545                 550                 555                 560 


Thr Thr Asp Arg Glu Glu Ala Thr Arg Leu Leu Ala Glu Lys Arg Arg 
                565                 570                 575     


Gln Ala Arg Glu Gln Arg Glu Arg Glu Glu Gln Glu Arg Arg Leu Gln 
            580                 585                 590         


Ala Glu Arg Asp Lys Arg Met Arg Glu Glu Gln Leu Ala Arg Glu Ala 
        595                 600                 605             


Glu Ala Arg Ala Glu Arg Glu Ala Glu Ala Arg Arg Arg Glu Glu Gln 
    610                 615                 620                 


Glu Ala Arg Glu Lys Ala Gln Ala Glu Gln Glu Glu Gln Glu Arg Leu 
625                 630                 635                 640 


Gln Lys Gln Lys Glu Glu Ala Glu Ala Arg Ser Arg Glu Glu Ala Glu 
                645                 650                 655     


Arg Gln Arg Leu Glu Arg Glu Lys His Phe Gln Gln Gln Glu Gln Glu 
            660                 665                 670         


Arg Gln Glu Arg Arg Lys Arg Leu Glu Glu Ile Met Lys Arg Thr Arg 
        675                 680                 685             


Lys Ser Glu Val Ser Glu Thr Lys Lys Gln Asp Ser Lys Glu Ala Asn 
    690                 695                 700                 


Ala Asn Gly Ser Ser Pro Glu Pro Val Lys Ala Val Glu Ala Arg Ser 
705                 710                 715                 720 


Pro Gly Leu Gln Lys Glu Ala Val Gln Lys Glu Glu Pro Ile Pro Gln 
                725                 730                 735     


Glu Pro Gln Trp Ser Leu Pro Ser Lys Glu Leu Pro Ala Ser Leu Val 
            740                 745                 750         


Asn Gly Leu Gln Pro Leu Pro Ala His Gln Glu Asn Gly Phe Ser Thr 
        755                 760                 765             


Asn Gly Pro Ser Gly Asp Lys Ser Leu Ser Arg Thr Pro Glu Thr Leu 
    770                 775                 780                 


Leu Pro Phe Ala Glu Ala Glu Ala Phe Leu Lys Lys Ala Val Val Gln 
785                 790                 795                 800 


Ser Pro Gln Val Thr Glu Val Leu 
                805             


<210>  6015
<211>  3739
<212>  DNA
<213>  Homosapiens

<400>  6015
cttgtgactc tccttcatgc ctcccgacgt cccccgggcc gctttggttt aggtgggttt     60

gagcgagaat ttggactcga agctgccctc tcagccccag tgccagagcc cccaaactcc    120

agggtgggaa aggggagtcc cagccctgct ccccctctcc cccagtcccc gcggcgggtg    180

agtcacccga gcgctcccta cttagtcctc aggcgctgcg gcgcgtacca agacgcggac    240

gcagggggag gcagctagcg cggcgaactc ctggagccgt ggagcccgct cggccgtggc    300

cgtgggagag gcgccgggag gctgcgggcg cggggctccg gggcgggggc ggcgcgaacg    360

gcgcggacgg cgcgggcgcg gggggctggg tcccggggcg ctgctggggt ggaccccccc    420

gcctcgaact tggtacgcgc cagcgagagg ccaggcccag cccgggcggt acaatagggt    480

tgggccgagg ccgggactgg gccggcgccg ggcggggaac gggttcgcga ccgcagccga    540

gagaccccgg gcgaccggca cctccgagac tcgcgggcca cctgcctcga ccttccccgg    600

agcgcccccg cctccgagtc gctacttgcc gggccgggcc gggccgggcg tgatgcgccg    660

cgggacccct gtcctggcca ctggccgccg ccgccgccgc cgctgagacc ccgagacccc    720

cagtgacgcc gcagccatgg agagcggccc gcgtgcggag ctgggggcgg gcgcaccccc    780

agctgtggtc gccaggaccc ccccagagcc aagaccttct ccagaaggtg acccttcccc    840

cccaccacca ccaatgtcag ccctggtccc cgacactccc ccggacaccc ctcctgccat    900

gaagaatgcc actagctcta agcagctccc actggaacca gagagcccct cagggcaggt    960

cgggcctagg ccagcccccc cgcaggaaga gtccccttcc tctgaagcaa agagcagagg   1020

acccacccca ccagccatgg gcccacggga tgccagacct cctcgaagga gcagccagcc   1080

atctccaaca gcagtgccag cctccgacag ccctcccacc aagcaagagg tgaagaaggc   1140

aggagagaga cacaagctgg caaaggagcg gcgagaagag cgggccaagt acctggcggc   1200

caagaaggca gtgtggctgg agaaggagga gaaggccaag gcgctgcggg agaagcagct   1260

ccaggagcgc cggcgccggc tggaggagca acgtcttaaa gccgagcaac gccgtgcagc   1320

cctggaggaa cggcagcggc agaagctcga gaaaaacaag gagcgctatg aagcagccat   1380

ccaacggtca gtgaagaaga cgtgggccga aatccggcag cagcgctggt cctgggcagg   1440

ggccctgcac cacagctctc caggacataa gaccaatcgc agcctgcagc tgagcgcatg   1500

ggagagcagc atcgtggatc gtctgatgac gcccactctc tccttccttg ctcggagtcg   1560

cagcgcggtc acactgcccc gcaacggccg ggaccagggt aggggctgcg accctgggag   1620

aggccccacg tggggccggg caggggccag cctggcgcgc gggccgcaac ccgaccgcac   1680

tcatccctct gcagccgtgc cggtgtgccc gcgctcggcc tccgccagcc ccctgacgcc   1740

gtgcagcgtc acccgaagcg tgcaccgctg cgcccccgcc ggtgagcgcg gggagcgccg   1800

caagcccaac gccgggggca gccccgctcc ggtgcgccgc cggccggagg cctcgccggt   1860

gcagaaaaag gagaagaagg acaaggagcg ggaaaacgag aaggagaaga gtgccctagc   1920

ccgggagcgc agcctcaaga agcgccagtc gctgcccgcc tccccacgtg cccgcctctc   1980

tgccagcacc gcctctgagc tcagccccaa atccaaggcc aggccatcct ctccctccac   2040

atcctggcac aggcctgcct ccccctgccc cagcccaggg ccaggccaca ctctgcctcc   2100

aaagccaccg tccccccgag gcaccactgc atcccccaag gggcgggttc ggaggaagga   2160

ggaggcaaag gagagcccca gcgccgcagg gcccgaggac aagagccaga gcaagcgcag   2220

ggccagtaac gagaaggagt cagcagcccc agcctcaccg gcaccttcgc cggcgccctc   2280

gcccacccca gccccgcccc agaaggagca gccccccgcg gagaccccta cagacgctgc   2340

tgtcttgacc tcacccccag cccctgctcc cccggtgacc cctagcaaac caatggccgg   2400

caccacagac cgagaagaag ccactcggct cttggctgag aagcggcgcc aggcccggga   2460

gcagcgggag cgcgaggagc aggagcggag gctgcaggca gaaagggaca agcgaatgcg   2520

agaggagcag ctggcacggg aggccgaggc ccgggcggag cgggaggcgg aggcccggag   2580

gcgggaggag caggaggcac gagagaaggc gcaggccgag caggaggagc aggagcggct   2640

gcagaagcag aaagaggagg ccgaagctcg gtcgcgggaa gaggcggagc ggcagcgtct   2700

ggagcgggaa aagcacttcc agcagcagga gcaagagcgg caagagcgca gaaagcgtct   2760

ggaggagatc atgaagagga ctcggaagtc agaagtttct gaaaccaaga agcaggacag   2820

caaggaggcc aacgccaacg gttccagccc agagcctgtg aaagctgtgg aggctcggtc   2880

cccagggctg cagaaggagg ctgtgcagaa agaggagccc atcccacagg agcctcagtg   2940

gagtctccca agcaaggagt tgccagcgtc cctggtgaat ggcctgcagc ctctcccagc   3000

acaccaggag aatggcttct ccaccaacgg accctctggg gacaagagtc tgagccgaac   3060

accagagaca ctcctgccct ttgcagaggc agaagccttc ctcaagaaag ctgtggtgca   3120

gtccccgcag gtcacagaag tcctttaaga gggtttgcct tggatccggg cacagttgtg   3180

agggctcctc tgcatcacct accaggatgt ctggaggaga aaaagacaga acaaagatgg   3240

aagtggcctg ggcccctggg ggtgggtcct ctctgttgtt tttaatctgc accttataga   3300

ctgatgtctc tttggccgga gccagatctg cccctcagtg cattcgtgtg ctcgcacgcg   3360

cagacatccc ttctccccca tacacacata tacactcaca gcctctctgg cctcttccct   3420

tggggagggg ccacctgtag tatttgcctt gatttggtgg ggtacagtgg atgtgaatac   3480

tgtaaatagc ttgtgctcag actcctctgc gtggagaggg tgggtgcagg aggcagaccc   3540

tccccccaaa gccccctggg gagatcttcc tctctctatt taactgtaac tgagggggat   3600

cccaggtctg gggatggggg acaccttggg ccacaggata ctggttgctt caggggtacc   3660

catgccccct gccctcgcct ggaatcagtg ttactgcatc tgattaaatg tctccagaaa   3720

taaagaataa ttctgccaa                                                3739


<210>  6016
<211>  803
<212>  PRT
<213>  Homosapiens

<400>  6016

Met Glu Ser Gly Pro Arg Ala Glu Leu Gly Ala Gly Ala Pro Pro Ala 
1               5                   10                  15      


Val Val Ala Arg Thr Pro Pro Glu Pro Arg Pro Ser Pro Glu Gly Asp 
            20                  25                  30          


Pro Ser Pro Pro Pro Pro Pro Met Ser Ala Leu Val Pro Asp Thr Pro 
        35                  40                  45              


Pro Asp Thr Pro Pro Ala Met Lys Asn Ala Thr Ser Ser Lys Gln Leu 
    50                  55                  60                  


Pro Leu Glu Pro Glu Ser Pro Ser Gly Gln Val Gly Pro Arg Pro Ala 
65                  70                  75                  80  


Pro Pro Gln Glu Glu Ser Pro Ser Ser Glu Ala Lys Ser Arg Gly Pro 
                85                  90                  95      


Thr Pro Pro Ala Met Gly Pro Arg Asp Ala Arg Pro Pro Arg Arg Ser 
            100                 105                 110         


Ser Gln Pro Ser Pro Thr Ala Val Pro Ala Ser Asp Ser Pro Pro Thr 
        115                 120                 125             


Lys Gln Glu Val Lys Lys Ala Gly Glu Arg His Lys Leu Ala Lys Glu 
    130                 135                 140                 


Arg Arg Glu Glu Arg Ala Lys Tyr Leu Ala Ala Lys Lys Ala Val Trp 
145                 150                 155                 160 


Leu Glu Lys Glu Glu Lys Ala Lys Ala Leu Arg Glu Lys Gln Leu Gln 
                165                 170                 175     


Glu Arg Arg Arg Arg Leu Glu Glu Gln Arg Leu Lys Ala Glu Gln Arg 
            180                 185                 190         


Arg Ala Ala Leu Glu Glu Arg Gln Arg Gln Lys Leu Glu Lys Asn Lys 
        195                 200                 205             


Glu Arg Tyr Glu Ala Ala Ile Gln Arg Ser Val Lys Lys Thr Trp Ala 
    210                 215                 220                 


Glu Ile Arg Gln Gln Arg Trp Ser Trp Ala Gly Ala Leu His His Ser 
225                 230                 235                 240 


Ser Pro Gly His Lys Thr Asn Arg Ser Leu Gln Leu Ser Ala Trp Glu 
                245                 250                 255     


Ser Ser Ile Val Asp Arg Leu Met Thr Pro Thr Leu Ser Phe Leu Ala 
            260                 265                 270         


Arg Ser Arg Ser Ala Val Thr Leu Pro Arg Asn Gly Arg Asp Gln Gly 
        275                 280                 285             


Arg Gly Cys Asp Pro Gly Arg Gly Pro Thr Trp Gly Arg Ala Gly Ala 
    290                 295                 300                 


Ser Leu Ala Arg Gly Pro Gln Pro Asp Arg Thr His Pro Ser Ala Ala 
305                 310                 315                 320 


Val Pro Val Cys Pro Arg Ser Ala Ser Ala Ser Pro Leu Thr Pro Cys 
                325                 330                 335     


Ser Val Thr Arg Ser Val His Arg Cys Ala Pro Ala Gly Glu Arg Gly 
            340                 345                 350         


Glu Arg Arg Lys Pro Asn Ala Gly Gly Ser Pro Ala Pro Val Arg Arg 
        355                 360                 365             


Arg Pro Glu Ala Ser Pro Val Gln Lys Lys Glu Lys Lys Asp Lys Glu 
    370                 375                 380                 


Arg Glu Asn Glu Lys Glu Lys Ser Ala Leu Ala Arg Glu Arg Ser Leu 
385                 390                 395                 400 


Lys Lys Arg Gln Ser Leu Pro Ala Ser Pro Arg Ala Arg Leu Ser Ala 
                405                 410                 415     


Ser Thr Ala Ser Glu Leu Ser Pro Lys Ser Lys Ala Arg Pro Ser Ser 
            420                 425                 430         


Pro Ser Thr Ser Trp His Arg Pro Ala Ser Pro Cys Pro Ser Pro Gly 
        435                 440                 445             


Pro Gly His Thr Leu Pro Pro Lys Pro Pro Ser Pro Arg Gly Thr Thr 
    450                 455                 460                 


Ala Ser Pro Lys Gly Arg Val Arg Arg Lys Glu Glu Ala Lys Glu Ser 
465                 470                 475                 480 


Pro Ser Ala Ala Gly Pro Glu Asp Lys Ser Gln Ser Lys Arg Arg Ala 
                485                 490                 495     


Ser Asn Glu Lys Glu Ser Ala Ala Pro Ala Ser Pro Ala Pro Ser Pro 
            500                 505                 510         


Ala Pro Ser Pro Thr Pro Ala Pro Pro Gln Lys Glu Gln Pro Pro Ala 
        515                 520                 525             


Glu Thr Pro Thr Asp Ala Ala Val Leu Thr Ser Pro Pro Ala Pro Ala 
    530                 535                 540                 


Pro Pro Val Thr Pro Ser Lys Pro Met Ala Gly Thr Thr Asp Arg Glu 
545                 550                 555                 560 


Glu Ala Thr Arg Leu Leu Ala Glu Lys Arg Arg Gln Ala Arg Glu Gln 
                565                 570                 575     


Arg Glu Arg Glu Glu Gln Glu Arg Arg Leu Gln Ala Glu Arg Asp Lys 
            580                 585                 590         


Arg Met Arg Glu Glu Gln Leu Ala Arg Glu Ala Glu Ala Arg Ala Glu 
        595                 600                 605             


Arg Glu Ala Glu Ala Arg Arg Arg Glu Glu Gln Glu Ala Arg Glu Lys 
    610                 615                 620                 


Ala Gln Ala Glu Gln Glu Glu Gln Glu Arg Leu Gln Lys Gln Lys Glu 
625                 630                 635                 640 


Glu Ala Glu Ala Arg Ser Arg Glu Glu Ala Glu Arg Gln Arg Leu Glu 
                645                 650                 655     


Arg Glu Lys His Phe Gln Gln Gln Glu Gln Glu Arg Gln Glu Arg Arg 
            660                 665                 670         


Lys Arg Leu Glu Glu Ile Met Lys Arg Thr Arg Lys Ser Glu Val Ser 
        675                 680                 685             


Glu Thr Lys Lys Gln Asp Ser Lys Glu Ala Asn Ala Asn Gly Ser Ser 
    690                 695                 700                 


Pro Glu Pro Val Lys Ala Val Glu Ala Arg Ser Pro Gly Leu Gln Lys 
705                 710                 715                 720 


Glu Ala Val Gln Lys Glu Glu Pro Ile Pro Gln Glu Pro Gln Trp Ser 
                725                 730                 735     


Leu Pro Ser Lys Glu Leu Pro Ala Ser Leu Val Asn Gly Leu Gln Pro 
            740                 745                 750         


Leu Pro Ala His Gln Glu Asn Gly Phe Ser Thr Asn Gly Pro Ser Gly 
        755                 760                 765             


Asp Lys Ser Leu Ser Arg Thr Pro Glu Thr Leu Leu Pro Phe Ala Glu 
    770                 775                 780                 


Ala Glu Ala Phe Leu Lys Lys Ala Val Val Gln Ser Pro Gln Val Thr 
785                 790                 795                 800 


Glu Val Leu 
            


<210>  6017
<211>  1417
<212>  DNA
<213>  Homosapiens

<400>  6017
cgaggccggg actgggccgg cgccgggcgg ggaacgggtt cgcgaccgca gccgagagac     60

cccgggcgac cggcacctcc gagactcgcg ggccacctgc ctcgaccttc cccggagcgc    120

ccccgcctcc gagtcgctac ttgccgggcc gggccgggcc gggcgtgatg cgccgcggga    180

cccctgtcct ggccactggc cgccgccgcc gccgccgctg agaccccgag acccccagtg    240

acgccgcagc catggagagc ggcccgcgtg cggagctggg ggcgggcgca cccccagctg    300

tggtcgccag gaccccccca gagccaagac cttctccaga aggtggtggc tgggggtggg    360

gacaggcagg cagccttttc tgcaaccaca gccagctggt ctgggccaac cttagccagg    420

tggcattgtc cccatgtgtc agactggcct gggtgctgtg gggtggaggg gtccctcatt    480

ctggctccac cctagagggc ccatgcaatc ctgccctctc tgtcttcaga gccccagtca    540

tggccttggc tggtcccaga gttgagccaa ccaaggtggc atagcccctg cattcccacc    600

atgccctggt gctcatatgt gaaggagcca tggtgggagt tatttataag tttctcttgc    660

atttgtttgg ctgctttgtt gcctagcaac caaatcagct gctgtaccaa ccccacctga    720

ctgaggctta aaaatagccc agcagctgag gggacagagc agggtggcct agggcaggca    780

ggcaccctag cagcctctcc ctggcacagg actgctaaaa gctgggtcag aggagcacaa    840

ggaccctcac tgtcctgaat ccatgggaca gcctcggctg ggtcagccct ctgacagcag    900

gaggggcaag accttacact gggacatggc agagggcaat tgggttttct tccaatcctg    960

gatggctcct tcctatatgc gccgttcagg gccccttcac ctggggagcg ttgtaggcgg   1020

ggaccctcat ccgatgcagg atgttgccct gggaagtgtc tggttgcctg ggtctgtagt   1080

ggaagtccag atcataggga ggacaagtgt ggccccggtg tgattgtggg gagaggactc   1140

ccgggtgaga agccttggcc ttggcatggg gatggtgcct ggtctgctcc cttgcctctt   1200

cctgcctcct acggccccca cggtgaccgg cttcgcctgg ccttctaccc ccagatcgca   1260

gcctgcagct gagcgcatgg gagagcagca tcgtggatcg tctgatgacg cccactctct   1320

ccttccttgc tcggagtcgc agcgcggtca cactgccccg caacggccgg gaccagggta   1380

ggggctgcga ccctgggaga ggccccacgt ggggccg                            1417


<210>  6018
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  6018

Met Glu Ser Gly Pro Arg Ala Glu Leu Gly Ala Gly Ala Pro Pro Ala 
1               5                   10                  15      


Val Val Ala Arg Thr Pro Pro Glu Pro Arg Pro Ser Pro Glu Gly Gly 
            20                  25                  30          


Gly Trp Gly Trp Gly Gln Ala Gly Ser Leu Phe Cys Asn His Ser Gln 
        35                  40                  45              


Leu Val Trp Ala Asn Leu Ser Gln Val Ala Leu Ser Pro Cys Val Arg 
    50                  55                  60                  


Leu Ala Trp Val Leu Trp Gly Gly Gly Val Pro His Ser Gly Ser Thr 
65                  70                  75                  80  


Leu Glu Gly Pro Cys Asn Pro Ala Leu Ser Val Phe Arg Ala Pro Val 
                85                  90                  95      


Met Ala Leu Ala Gly Pro Arg Val Glu Pro Thr Lys Val Ala 
            100                 105                 110 


<210>  6019
<211>  1841
<212>  DNA
<213>  Homosapiens

<400>  6019
atgtatgatg atgccactgc actccagcct gggggtcagc cagattctgt cttaaaaaca     60

acaacaacaa caacaacaaa acctgctgaa tgaatggacc tgtcagcccc aaatccaagg    120

ccaggccatc ctctccctcc acatcctggc acaggcctgc ctccccctgc cccagcccag    180

ggccaggcca cactctgcct ccaaagccac cgtccccccg aggcaccact gcatccccca    240

aggggcgggt tcggaggaag gaggaggcaa aggagagccc cagcgccgca gggcccgagg    300

acaagagcca gagcaagcgc agggccagta acgagaagga gtcagcagcc ccagcctcac    360

cggcaccttc gccggcgccc tcgcccaccc cagccccgcc ccagaaggag cagccccccg    420

cggagacccc tacagacgct gctgtcttga cctcaccccc agcccctgct cccccggtga    480

cccctagcaa accaatggcc ggcaccacag accgagaaga agccactcgg ctcttggctg    540

agaagcggcg ccaggcccgg gagcagcggg agcgcgagga gcaggagcgg aggctgcagg    600

cagaaaggga caagcgaatg cgagaggagc agctggcacg ggaggccgag gcccgggcgg    660

agcgggaggc ggaggcccgg aggcgggagg agcaggaggc acgagagaag gcgcaggccg    720

agcaggagga gcaggagcgg ctgcagaagc agaaagagga ggccgaagct cggtcgcggg    780

aagaggcgga gcggcagcgt ctggagcggg aaaagcactt ccagcagcag gagcaagagc    840

ggcaagagcg cagaaagcgt ctggaggaga tcatgaagag gactcggaag tcagaagttt    900

ctgaaaccaa gaagcaggac agcaaggagg ccaacgccaa cggttccagc ccagagcctg    960

tgaaagctgt ggaggctcgg tccccagggc tgcagaagga ggctgtgcag aaagaggagc   1020

ccatcccaca ggagcctcag tggagtctcc caagcaagga gttgccagcg tccctggtga   1080

atggcctgca gcctctccca gcacaccagg agaatggctt ctccaccaac ggaccctctg   1140

gggacaagag tctgagccga acaccagaga cactcctgcc ctttgcagag gcagaagcct   1200

tcctcaagaa agctgtggtg cagtccccgc aggtcacaga agtcctttaa gagggtttgc   1260

cttggatccg ggcacagttg tgagggctcc tctgcatcac ctaccaggat gtctggagga   1320

gaaaaagaca gaacaaagat ggaagtggcc tgggcccctg ggggtgggtc ctctctgttg   1380

tttttaatct gcaccttata gactgatgtc tctttggccg gagccagatc tgcccctcag   1440

tgcattcgtg tgctcgcacg cgcagacatc ccttctcccc catacacaca tatacactca   1500

cagcctctct ggcctcttcc cttggggagg ggccacctgt agtatttgcc ttgatttggt   1560

ggggtacagt ggatgtgaat actgtaaata gcttgtgctc agactcctct gcgtggagag   1620

ggtgggtgca ggaggcagac cctcccccca aagccccctg gggagatctt cctctctcta   1680

tttaactgta actgaggggg atcccaggtc tggggatggg ggacaccttg ggccacagga   1740

tactggttgc ttcaggggta cccatgcccc ctgccctcgc ctggaatcag tgttactgca   1800

tctgattaaa tgtctccaga aataaagaat aattctgcca a                       1841


<210>  6020
<211>  386
<212>  PRT
<213>  Homosapiens

<400>  6020

Met Asn Gly Pro Val Ser Pro Lys Ser Lys Ala Arg Pro Ser Ser Pro 
1               5                   10                  15      


Ser Thr Ser Trp His Arg Pro Ala Ser Pro Cys Pro Ser Pro Gly Pro 
            20                  25                  30          


Gly His Thr Leu Pro Pro Lys Pro Pro Ser Pro Arg Gly Thr Thr Ala 
        35                  40                  45              


Ser Pro Lys Gly Arg Val Arg Arg Lys Glu Glu Ala Lys Glu Ser Pro 
    50                  55                  60                  


Ser Ala Ala Gly Pro Glu Asp Lys Ser Gln Ser Lys Arg Arg Ala Ser 
65                  70                  75                  80  


Asn Glu Lys Glu Ser Ala Ala Pro Ala Ser Pro Ala Pro Ser Pro Ala 
                85                  90                  95      


Pro Ser Pro Thr Pro Ala Pro Pro Gln Lys Glu Gln Pro Pro Ala Glu 
            100                 105                 110         


Thr Pro Thr Asp Ala Ala Val Leu Thr Ser Pro Pro Ala Pro Ala Pro 
        115                 120                 125             


Pro Val Thr Pro Ser Lys Pro Met Ala Gly Thr Thr Asp Arg Glu Glu 
    130                 135                 140                 


Ala Thr Arg Leu Leu Ala Glu Lys Arg Arg Gln Ala Arg Glu Gln Arg 
145                 150                 155                 160 


Glu Arg Glu Glu Gln Glu Arg Arg Leu Gln Ala Glu Arg Asp Lys Arg 
                165                 170                 175     


Met Arg Glu Glu Gln Leu Ala Arg Glu Ala Glu Ala Arg Ala Glu Arg 
            180                 185                 190         


Glu Ala Glu Ala Arg Arg Arg Glu Glu Gln Glu Ala Arg Glu Lys Ala 
        195                 200                 205             


Gln Ala Glu Gln Glu Glu Gln Glu Arg Leu Gln Lys Gln Lys Glu Glu 
    210                 215                 220                 


Ala Glu Ala Arg Ser Arg Glu Glu Ala Glu Arg Gln Arg Leu Glu Arg 
225                 230                 235                 240 


Glu Lys His Phe Gln Gln Gln Glu Gln Glu Arg Gln Glu Arg Arg Lys 
                245                 250                 255     


Arg Leu Glu Glu Ile Met Lys Arg Thr Arg Lys Ser Glu Val Ser Glu 
            260                 265                 270         


Thr Lys Lys Gln Asp Ser Lys Glu Ala Asn Ala Asn Gly Ser Ser Pro 
        275                 280                 285             


Glu Pro Val Lys Ala Val Glu Ala Arg Ser Pro Gly Leu Gln Lys Glu 
    290                 295                 300                 


Ala Val Gln Lys Glu Glu Pro Ile Pro Gln Glu Pro Gln Trp Ser Leu 
305                 310                 315                 320 


Pro Ser Lys Glu Leu Pro Ala Ser Leu Val Asn Gly Leu Gln Pro Leu 
                325                 330                 335     


Pro Ala His Gln Glu Asn Gly Phe Ser Thr Asn Gly Pro Ser Gly Asp 
            340                 345                 350         


Lys Ser Leu Ser Arg Thr Pro Glu Thr Leu Leu Pro Phe Ala Glu Ala 
        355                 360                 365             


Glu Ala Phe Leu Lys Lys Ala Val Val Gln Ser Pro Gln Val Thr Glu 
    370                 375                 380                 


Val Leu 
385     


<210>  6021
<211>  4433
<212>  DNA
<213>  Homosapiens

<400>  6021
ggagacgctg ggcgcgctgt ggggcggggg cgaggttcgg gctggttgtt ccgttgcgag     60

ctgcagctgc gatctctgtg gtaggcccag aagtgtatgc tgacttgtaa agtgaagaag    120

ccagtggtgc tgcgggtgtt cttttggggt agtgtctggg atccagtacg agttgaatca    180

ttgttcaaat aaggtgtaat tgaaaagtga tcctctcttc agagatgtca aaaacaaaca    240

aatccaagtc tggatctcgc tcttctcgct caagatctgc atcaagatct cgttctcgtt    300

cattttcgaa gtctcggtcc cgaagccgat ctctctctcg ttcaaggaag cgcaggctga    360

gttctaggtc tcgttccaga tcatattctc cagctcataa cagagaaaga aaccacccaa    420

gagtatatca gaatcgggat ttccgaggtc acaacagagg ctatagaagg ccctattatt    480

tccgtgggcg taacagaggc ttttatccat ggggccaata taaccgagga ggctatggaa    540

actaccgctc aaattggcag aattaccggc aagcatacag tcctcgtcga ggccgttcaa    600

gatcccggtc cccaaagaga aggtcccctt caccaaggtc caggagccat tctagaaact    660

ctgataagtc gtcttctgac cggtcaaggc gctcctcatc ctcccgttct tcctccaacc    720

atagccgagt tgaatcttct aagcgcaagt ctgcaaagga gaaaaagtcc tcttctaagg    780

atagccggcc atctcaggct gccggggata accagggaga tgaggccaag gagcagacat    840

tctctggagg cacctctcaa gatacaaaag catctgagag ctcgaagcca tggccagatg    900

ccacctacgg cactggttct gcatcacggg cctcagcagt ttctgagctg agtcctcggg    960

agcgaagccc agctctcaaa agccccctcc agtctgtggt ggtgaggcgg cggtcacccc   1020

gtcctagccc cgtgccaaaa cctagtcctc cactttccag cacatcccag atgggctcaa   1080

ctctgccgag tggtgccggg tatcagtctg ggacacacca aggtcagttc gaccatggtt   1140

ctgggtccct gagtccatcc aaaaagagcc ctgtgggtaa gagtccacca tccactggct   1200

ccacatatgg ctcatctcag aaggaggaga gtgctgcttc aggaggagca gcctatacaa   1260

agaggtatct agaagagcag aagacagaga atggaaaaga taaggaacag aaacaaacaa   1320

ataccgataa agaaaaaata aaagagaaag ggagcttctc tgacacaggc ttgggtgatg   1380

gaaaaatgaa atctgattct tttgctccca aaactgattc tgagaagcct tttcggggca   1440

gtcagtctcc caaaaggtat aagctccgag atgactttga gaagaagatg gctgacttcc   1500

acaaggagga gatggatgat caagataagg acaaagctaa gggaagaaag gaatctgagt   1560

ttgatgatga acccaaattt atgtctaaag tcataggtgc aaacaaaaac caggaggagg   1620

agaagtcagg caaatgggag ggcctggtat atgcacctcc agggaaggaa aagcagagaa   1680

aaacagagga gctggaggag gagtctttcc cagagagatc caaaaaggaa gatcggggca   1740

agagaagcga aggtgggcac aggggctttg tgcctgagaa gaatttccga gtgactgctt   1800

ataaagcagt ccaggagaaa agctcatcac ctcccccaag aaagacctct gagagccgag   1860

acaagctggg agcgaaagga gattttccca caggaaagtc ttccttttcc attactcgag   1920

aggcacaggt caatgtccgg atggactctt ttgatgagga cctcgcacga cccagtggct   1980

tattggctca ggaacgcaag ctttgccgag atctagtcca tagcaacaaa aaggaacagg   2040

agtttcgttc cattttccag cacatacaat cagctcagtc tcagcgtagc ccctcagaac   2100

tgtttgccca acatatagtg accattgttc accatgttaa agagcatcac tttgggtcct   2160

caggaatgac attacatgaa cgctttacta aatacctaaa gagaggaact gagcaggagg   2220

cagccaaaaa caagaaaagc ccagagatac acaggagaat agacatttcc cccagtacat   2280

tcagaaaaca tggtttggct catgatgaaa tgaaaagtcc ccgggaacct ggctacaagg   2340

ctgagggaaa atacaaagat gatcctgttg atctccgcct tgatattgaa cgtcgtaaaa   2400

aacataagga gagagatctt aaacgaggta aatcgagaga atcagtggat tcccgagact   2460

ccagtcactc aagggaaagg tcagctgaaa aaacagagaa aactcataaa ggatcaaaga   2520

aacagaagaa gcatcggaga gcaagagaca ggtccagatc ctcctcctct tcctcccagt   2580

catctcactc ctacaaagca gaagagtaca ctgaagagac agaggaaaga gaggagagca   2640

ccacgggctt tgacaaatca agactgggga ccaaagactt tgtgggtcca agtgaaagag   2700

gaggtggcag agctcgagga acctttcagt ttcgagccag aggaagaggc tggggcagag   2760

gcaactactc tgggaacaat aacaacaaca gcaacaacga ttttcaaaaa agaaaccggg   2820

aagaggagtg ggacccagag tacacaccca aaagcaagaa gtattacttg catgatgacc   2880

gtgaaggcga aggcagtgac aagtgggtga gccggggccg gggccgagga gcctttcctc   2940

ggggtcgggg ccggttcatg ttccggaaat caagtaccag ccccaagtgg gcccatgaca   3000

agttcagtgg ggaggaaggg gagattgaag acgacgagag tgggacagag aaccgagaag   3060

agaaggacaa tatacagccc acaaccgagt aggggccacc cttgacggga ttcctgccca   3120

ggggagagag gcgctgggaa gatggctggt gaggagctta acagaggaac ctcaagaaga   3180

ttctgaaaat cctaccccca ccccccacca gccgcacaga ttgtactacc gcgagaggca   3240

tccctggcgc tgtctcccac tggacagagg aggctggcca tggggcccag gggtcaggcc   3300

cagcttttga gcagaataca acgcattggg ctttagctgt ttttctcatt tgttggtgtg   3360

tggggtgggg gcaggggtag ggcgggagag cgatgcttgg atttttgttt cctattagaa   3420

accaacagtt ttgttctaat ttcatttcat ttggagctaa gatgactaat ttgatgattt   3480

tcgatctctt ttcccctgtc ctgattttaa aagccccctc cttttttttt ttttttttct   3540

ttttttaggc atatgtagta atattagaaa catttaattt gggaaacttt gattcttgaa   3600

agagaaaaca aaagcatgtg aataaacttt gaagtgttca cctcagtttg ggaccaaact   3660

gcttggatct ttgtaaaaac cggttttgta tgtcaaggag gagtttaagg cctttccgac   3720

caccttgtgt tccccttttc tgcgcagcca tgtatcacgt ggagttgctc cttaccacac   3780

ctcacgtgcc cctgagccct atttcctgat ttcttctggg ctggacttcc ccgttctcca   3840

ccagcagctc cagtatccca aactttctag tcctgctgat cctcccagca acggggtgga   3900

aactggaggg cagtgtctgg tctgttttct aagaaactta tgaattctat tatctttaca   3960

aatatgagaa aattttttca atatttttta ttaatctttt tataaaatga aaagaaactc   4020

ctatgatcga ttaaggaagg tggttatggc tgggtggttc aggggttttt ttgggtttct   4080

tttttttttt ctttgtcttt ttaaccttaa gctgtttaag ttgaagcatt ctcagatgtt   4140

tggggggaaa catcctctta aaatgggtcc ttgtgcttgc cttctgggga ggcggtcctg   4200

agcaggtgaa tcataaggca tttatgcata tgttatatgc ggactgcacc cacctctccc   4260

ccccagcctt tgcctcttgc gttgttgtgc tgctttcccc ttactttgct acatttctat   4320

agttaagttg gttttacttg aatgattcat gtttaggggg aaaatgaaaa tctcccttaa   4380

aatttgtttc aactcctcct gcaaataaaa taaatgaagt ggcagatgta aac          4433


<210>  6022
<211>  955
<212>  PRT
<213>  Homosapiens

<400>  6022

Met Ser Lys Thr Asn Lys Ser Lys Ser Gly Ser Arg Ser Ser Arg Ser 
1               5                   10                  15      


Arg Ser Ala Ser Arg Ser Arg Ser Arg Ser Phe Ser Lys Ser Arg Ser 
            20                  25                  30          


Arg Ser Arg Ser Leu Ser Arg Ser Arg Lys Arg Arg Leu Ser Ser Arg 
        35                  40                  45              


Ser Arg Ser Arg Ser Tyr Ser Pro Ala His Asn Arg Glu Arg Asn His 
    50                  55                  60                  


Pro Arg Val Tyr Gln Asn Arg Asp Phe Arg Gly His Asn Arg Gly Tyr 
65                  70                  75                  80  


Arg Arg Pro Tyr Tyr Phe Arg Gly Arg Asn Arg Gly Phe Tyr Pro Trp 
                85                  90                  95      


Gly Gln Tyr Asn Arg Gly Gly Tyr Gly Asn Tyr Arg Ser Asn Trp Gln 
            100                 105                 110         


Asn Tyr Arg Gln Ala Tyr Ser Pro Arg Arg Gly Arg Ser Arg Ser Arg 
        115                 120                 125             


Ser Pro Lys Arg Arg Ser Pro Ser Pro Arg Ser Arg Ser His Ser Arg 
    130                 135                 140                 


Asn Ser Asp Lys Ser Ser Ser Asp Arg Ser Arg Arg Ser Ser Ser Ser 
145                 150                 155                 160 


Arg Ser Ser Ser Asn His Ser Arg Val Glu Ser Ser Lys Arg Lys Ser 
                165                 170                 175     


Ala Lys Glu Lys Lys Ser Ser Ser Lys Asp Ser Arg Pro Ser Gln Ala 
            180                 185                 190         


Ala Gly Asp Asn Gln Gly Asp Glu Ala Lys Glu Gln Thr Phe Ser Gly 
        195                 200                 205             


Gly Thr Ser Gln Asp Thr Lys Ala Ser Glu Ser Ser Lys Pro Trp Pro 
    210                 215                 220                 


Asp Ala Thr Tyr Gly Thr Gly Ser Ala Ser Arg Ala Ser Ala Val Ser 
225                 230                 235                 240 


Glu Leu Ser Pro Arg Glu Arg Ser Pro Ala Leu Lys Ser Pro Leu Gln 
                245                 250                 255     


Ser Val Val Val Arg Arg Arg Ser Pro Arg Pro Ser Pro Val Pro Lys 
            260                 265                 270         


Pro Ser Pro Pro Leu Ser Ser Thr Ser Gln Met Gly Ser Thr Leu Pro 
        275                 280                 285             


Ser Gly Ala Gly Tyr Gln Ser Gly Thr His Gln Gly Gln Phe Asp His 
    290                 295                 300                 


Gly Ser Gly Ser Leu Ser Pro Ser Lys Lys Ser Pro Val Gly Lys Ser 
305                 310                 315                 320 


Pro Pro Ser Thr Gly Ser Thr Tyr Gly Ser Ser Gln Lys Glu Glu Ser 
                325                 330                 335     


Ala Ala Ser Gly Gly Ala Ala Tyr Thr Lys Arg Tyr Leu Glu Glu Gln 
            340                 345                 350         


Lys Thr Glu Asn Gly Lys Asp Lys Glu Gln Lys Gln Thr Asn Thr Asp 
        355                 360                 365             


Lys Glu Lys Ile Lys Glu Lys Gly Ser Phe Ser Asp Thr Gly Leu Gly 
    370                 375                 380                 


Asp Gly Lys Met Lys Ser Asp Ser Phe Ala Pro Lys Thr Asp Ser Glu 
385                 390                 395                 400 


Lys Pro Phe Arg Gly Ser Gln Ser Pro Lys Arg Tyr Lys Leu Arg Asp 
                405                 410                 415     


Asp Phe Glu Lys Lys Met Ala Asp Phe His Lys Glu Glu Met Asp Asp 
            420                 425                 430         


Gln Asp Lys Asp Lys Ala Lys Gly Arg Lys Glu Ser Glu Phe Asp Asp 
        435                 440                 445             


Glu Pro Lys Phe Met Ser Lys Val Ile Gly Ala Asn Lys Asn Gln Glu 
    450                 455                 460                 


Glu Glu Lys Ser Gly Lys Trp Glu Gly Leu Val Tyr Ala Pro Pro Gly 
465                 470                 475                 480 


Lys Glu Lys Gln Arg Lys Thr Glu Glu Leu Glu Glu Glu Ser Phe Pro 
                485                 490                 495     


Glu Arg Ser Lys Lys Glu Asp Arg Gly Lys Arg Ser Glu Gly Gly His 
            500                 505                 510         


Arg Gly Phe Val Pro Glu Lys Asn Phe Arg Val Thr Ala Tyr Lys Ala 
        515                 520                 525             


Val Gln Glu Lys Ser Ser Ser Pro Pro Pro Arg Lys Thr Ser Glu Ser 
    530                 535                 540                 


Arg Asp Lys Leu Gly Ala Lys Gly Asp Phe Pro Thr Gly Lys Ser Ser 
545                 550                 555                 560 


Phe Ser Ile Thr Arg Glu Ala Gln Val Asn Val Arg Met Asp Ser Phe 
                565                 570                 575     


Asp Glu Asp Leu Ala Arg Pro Ser Gly Leu Leu Ala Gln Glu Arg Lys 
            580                 585                 590         


Leu Cys Arg Asp Leu Val His Ser Asn Lys Lys Glu Gln Glu Phe Arg 
        595                 600                 605             


Ser Ile Phe Gln His Ile Gln Ser Ala Gln Ser Gln Arg Ser Pro Ser 
    610                 615                 620                 


Glu Leu Phe Ala Gln His Ile Val Thr Ile Val His His Val Lys Glu 
625                 630                 635                 640 


His His Phe Gly Ser Ser Gly Met Thr Leu His Glu Arg Phe Thr Lys 
                645                 650                 655     


Tyr Leu Lys Arg Gly Thr Glu Gln Glu Ala Ala Lys Asn Lys Lys Ser 
            660                 665                 670         


Pro Glu Ile His Arg Arg Ile Asp Ile Ser Pro Ser Thr Phe Arg Lys 
        675                 680                 685             


His Gly Leu Ala His Asp Glu Met Lys Ser Pro Arg Glu Pro Gly Tyr 
    690                 695                 700                 


Lys Ala Glu Gly Lys Tyr Lys Asp Asp Pro Val Asp Leu Arg Leu Asp 
705                 710                 715                 720 


Ile Glu Arg Arg Lys Lys His Lys Glu Arg Asp Leu Lys Arg Gly Lys 
                725                 730                 735     


Ser Arg Glu Ser Val Asp Ser Arg Asp Ser Ser His Ser Arg Glu Arg 
            740                 745                 750         


Ser Ala Glu Lys Thr Glu Lys Thr His Lys Gly Ser Lys Lys Gln Lys 
        755                 760                 765             


Lys His Arg Arg Ala Arg Asp Arg Ser Arg Ser Ser Ser Ser Ser Ser 
    770                 775                 780                 


Gln Ser Ser His Ser Tyr Lys Ala Glu Glu Tyr Thr Glu Glu Thr Glu 
785                 790                 795                 800 


Glu Arg Glu Glu Ser Thr Thr Gly Phe Asp Lys Ser Arg Leu Gly Thr 
                805                 810                 815     


Lys Asp Phe Val Gly Pro Ser Glu Arg Gly Gly Gly Arg Ala Arg Gly 
            820                 825                 830         


Thr Phe Gln Phe Arg Ala Arg Gly Arg Gly Trp Gly Arg Gly Asn Tyr 
        835                 840                 845             


Ser Gly Asn Asn Asn Asn Asn Ser Asn Asn Asp Phe Gln Lys Arg Asn 
    850                 855                 860                 


Arg Glu Glu Glu Trp Asp Pro Glu Tyr Thr Pro Lys Ser Lys Lys Tyr 
865                 870                 875                 880 


Tyr Leu His Asp Asp Arg Glu Gly Glu Gly Ser Asp Lys Trp Val Ser 
                885                 890                 895     


Arg Gly Arg Gly Arg Gly Ala Phe Pro Arg Gly Arg Gly Arg Phe Met 
            900                 905                 910         


Phe Arg Lys Ser Ser Thr Ser Pro Lys Trp Ala His Asp Lys Phe Ser 
        915                 920                 925             


Gly Glu Glu Gly Glu Ile Glu Asp Asp Glu Ser Gly Thr Glu Asn Arg 
    930                 935                 940                 


Glu Glu Lys Asp Asn Ile Gln Pro Thr Thr Glu 
945                 950                 955 


<210>  6023
<211>  263
<212>  DNA
<213>  Homosapiens

<400>  6023
tgcgagctgc agctgcgatc tctgtggtag gcccagaagt gtatgctgac ttgtaaagtg     60

aagaagccag tggtgctgcg ggtgttcttt tggggtagtg tctgggatcc agtacgagtt    120

gaatcattgt tcaaataagg taaaagcatg gtggtaaaag aaactaataa cttcactaat    180

ttgtaaaacc aatcttacgt taagaattga ttatttcgag accagcctat gcaacatggt    240

gagatcctgt ctctacaaaa aat                                            263


<210>  6024
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  6024

Met Leu Thr Cys Lys Val Lys Lys Pro Val Val Leu Arg Val Phe Phe 
1               5                   10                  15      


Trp Gly Ser Val Trp Asp Pro Val Arg Val Glu Ser Leu Phe Lys 
            20                  25                  30      


<210>  6025
<211>  429
<212>  DNA
<213>  Homosapiens

<400>  6025
atggcgacta cgccagagtc ttcactggag gacccagtgc ggagctttgt gcaagttttg     60

gagaagtggg atggtacggt gctaccacta cagcagtatg gctctggcgg catgggttgc    120

atcgtttggg acgctgcata tgtcctttct aaatacctgg aaacgcctga gttttctggc    180

gactgggccc acacgctgag ccggcggttg gtgctggagc tgggttcggg caccggggcc    240

gtggggtgca tggccgctac cctcagggct aatgttgtag tcactgatct tgaggaattg    300

caagacttac atgagcaagc accttgtcac tggttctgtt caagccaagg tactgaaatg    360

gggggaagaa atagaagact ttcctcctcc actcgtctac atactgatgg ccgactgcat    420

atactatga                                                            429


<210>  6026
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  6026

Met Ala Thr Thr Pro Glu Ser Ser Leu Glu Asp Pro Val Arg Ser Phe 
1               5                   10                  15      


Val Gln Val Leu Glu Lys Trp Asp Gly Thr Val Leu Pro Leu Gln Gln 
            20                  25                  30          


Tyr Gly Ser Gly Gly Met Gly Cys Ile Val Trp Asp Ala Ala Tyr Val 
        35                  40                  45              


Leu Ser Lys Tyr Leu Glu Thr Pro Glu Phe Ser Gly Asp Trp Ala His 
    50                  55                  60                  


Thr Leu Ser Arg Arg Leu Val Leu Glu Leu Gly Ser Gly Thr Gly Ala 
65                  70                  75                  80  


Val Gly Cys Met Ala Ala Thr Leu Arg Ala Asn Val Val Val Thr Asp 
                85                  90                  95      


Leu Glu Glu Leu Gln Asp Leu His Glu Gln Ala Pro Cys His Trp Phe 
            100                 105                 110         


Cys Ser Ser Gln Gly Thr Glu Met Gly Gly Arg Asn Arg Arg Leu Ser 
        115                 120                 125             


Ser Ser Thr Arg Leu His Thr Asp Gly Arg Leu His Ile Leu 
    130                 135                 140         


<210>  6027
<211>  1955
<212>  DNA
<213>  Homosapiens

<400>  6027
cgcgagggcc actacattca ctgggaccac gtcatggtgc cgcactggga ccccaagatc     60

tcggccagct acccccgcgg ccgccacagc cccccagacg acttgggctc cagcttctac    120

ccggagctgg ggccctacag ctcccgggac cccgaagtgc tgcgggagca tatgacccag    180

ctcaaggaag ccgccatcgg cgtcctggtc ctgtcctggt acccacctgg catggctgat    240

gataacgggg agccctcaga tgacctggtg cccgccattc tggacaccgc ccatcagtac    300

agcatccagg tggccttcca catccaaccc tacaagggcc gggatgacat cactgtacat    360

gacaacatca agtacatcat tgacacgtat ggctcccatg gtgcatttta ccgctataag    420

aacagcatgg gcaagagcct cccactcttt tatatctacg actcatacct gacgtcccct    480

gaggcctggg cccacctcct gacaccaaac gggccccatt cgatccgcaa cacgccctac    540

gatggggtct tcatagcgct gctggtggag gagggccaca cccacgatat cctggccgcc    600

ggatttgacg gcatgtacac ctactttgcc tccaatggtt tctcctttgg ttcttcccat    660

cagaactgga aagctgtgaa gaacttttgt gatgccaaca acctcatgtt catccccagt    720

gtggggcctg gctacataga caccagcatt cggccctgga acaaccacaa tacgcgcaac    780

agggtcaatg gcaagtacta tgagacggcc ctgcaggcgg ccctgacagt gaggcccgag    840

atcgtttcca ttacctcctt caatgagtgg cacgagggca cccagattga gaaggccatt    900

cccaagaaga cacccacccg cctgtatttg gactacctgc ctcaccagcc cagcctgtac    960

ctggagctga cacgccgctg ggcggagcac ttcatcaaag agaaggagca gtggctcatg   1020

tgaggggcct gtaaatgggc gtgaggtgct gatgtccttg ccttgctgga agatgtcacc   1080

atgtggggtt cagctgaggt tgtagccact cactcgttcc caggtcagag gtcagcagat   1140

gggtgtttct gggtgggccg tcaggcatgg gcctgtgcaa cacagagccc gttcctcagg   1200

cgagtggtgc tgaggtgctc tgtggtgatg ggaacggcag aggctggcag gtgactgaac   1260

ttagcccagg gcagctccac atcctgggaa cactttcatg taaccccttc tagttttgaa   1320

ctctgcagca ggctggtgct gtgtagtggc cacccagtca ccacccttgg aagggtgtca   1380

gggtctgggc tcgcatgcac cctgctccct tctgccagcc tgcatcctct cctcaggcct   1440

ccttcccaca tcatctgtct tctctaagtt agggaaccat atttgagact ttcaaaaagg   1500

gaacttctag gtttaagctc ctcccagtag attcctgaac ccaattatca ggaaatcatc   1560

ctgagcactc acaggttcat ttaacactca ctcatcaagc accttcctat gtgctaggtg   1620

ctggggaaaa cttgaccaag gaagagttcc tgtcctgaag cttccaggac ccagctttcc   1680

ttttctggtg tggccttgta gctagtgcct gggcacaggt gtttttcttt ttgcagtttt   1740

acctagtgct gggagttcag ttctttttcc tctagaaaaa tacctctgtg ctccagagcc   1800

taatttttcc cagatgcata tttagctcta gggagaggac taggaggaaa tccccctccc   1860

tttagctgcc tgaactgact gaggcccact cactagagcc atgttcagtg ctactgtgat   1920

tagtagtaat taaatatgaa ctggtattct caagt                              1955


<210>  6028
<211>  329
<212>  PRT
<213>  Homosapiens

<400>  6028

Met Val Pro His Trp Asp Pro Lys Ile Ser Ala Ser Tyr Pro Arg Gly 
1               5                   10                  15      


Arg His Ser Pro Pro Asp Asp Leu Gly Ser Ser Phe Tyr Pro Glu Leu 
            20                  25                  30          


Gly Pro Tyr Ser Ser Arg Asp Pro Glu Val Leu Arg Glu His Met Thr 
        35                  40                  45              


Gln Leu Lys Glu Ala Ala Ile Gly Val Leu Val Leu Ser Trp Tyr Pro 
    50                  55                  60                  


Pro Gly Met Ala Asp Asp Asn Gly Glu Pro Ser Asp Asp Leu Val Pro 
65                  70                  75                  80  


Ala Ile Leu Asp Thr Ala His Gln Tyr Ser Ile Gln Val Ala Phe His 
                85                  90                  95      


Ile Gln Pro Tyr Lys Gly Arg Asp Asp Ile Thr Val His Asp Asn Ile 
            100                 105                 110         


Lys Tyr Ile Ile Asp Thr Tyr Gly Ser His Gly Ala Phe Tyr Arg Tyr 
        115                 120                 125             


Lys Asn Ser Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr Asp Ser 
    130                 135                 140                 


Tyr Leu Thr Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro Asn Gly 
145                 150                 155                 160 


Pro His Ser Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile Ala Leu 
                165                 170                 175     


Leu Val Glu Glu Gly His Thr His Asp Ile Leu Ala Ala Gly Phe Asp 
            180                 185                 190         


Gly Met Tyr Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser 
        195                 200                 205             


His Gln Asn Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn Leu 
    210                 215                 220                 


Met Phe Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg 
225                 230                 235                 240 


Pro Trp Asn Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr 
                245                 250                 255     


Glu Thr Ala Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile Val Ser 
            260                 265                 270         


Ile Thr Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala 
        275                 280                 285             


Ile Pro Lys Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His 
    290                 295                 300                 


Gln Pro Ser Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu His Phe 
305                 310                 315                 320 


Ile Lys Glu Lys Glu Gln Trp Leu Met 
                325                 


<210>  6029
<211>  3235
<212>  DNA
<213>  Homosapiens

<400>  6029
cgcgagggcc actacattca ctgggaccac gtcatggtgc cgcactggga ccccaagatc     60

tcggccagct acccccgcgg ccgccacagc cccccagacg acttgggctc cagcttctac    120

ccggagctgg ggccctacag ctcccgggac cccgaagtgc tgcgggagca tatgacccag    180

ctcaaggaag ccgccatcgg cgtcctggtc ctgtcctggt acccacctgg catggctgat    240

gataacgggg agccctcaga tgacctggtg cccgccattc tggacaccgc ccatcagtac    300

agcatccagg tggccttcca catccaaccc tacaagggcc gggatgacat cactgtacat    360

gacaacatca agtacatcat tgacacgtat ggctcccatg gtgcatttta ccgctataag    420

aacagcatgg gcaagagcct cccactcttt tatatctacg actcatacct gacgtcccct    480

gaggcctggg cccacctcct gacaccaaac gggccccatt cgatccgcaa cacgccctac    540

gatggggtct tcatagcgct gctggtggag gagggccaca cccacgatat cctggccgcc    600

ggatttgacg gcatgtacac ctactttgcc tccaatggtt tctcctttgg ttcttcccat    660

cagaactgga aagctgtgaa gaacttttgt gatgccaaca acctcatgtt catccccagt    720

gtggggcctg gctacataga caccagcatt cggccctgga acaaccacaa tacgcgcaac    780

agggtcaatg gcaagtacta tgagacggcc ctgcaggcgg ccctgacagt gaggcccgag    840

atcgtttcca ttacctcctt caatgagtgg cacgagggca cccagattga gaaggccatt    900

cccaagaaga cacccacccg cctgtatttg gactacctgc ctcaccagcc cagcctgtac    960

ctggagctga cacgccgctg ggcggagcac ttcatcaaag agaaggagca gtggctcatg   1020

tgaggggcct gtaaatgggc gtgaggtgct gatgtccttg ccttgctgga agatgtcacc   1080

atgtggggtt cagctgaggt tgtagccact cactcgttcc caggtcagag gtcagcagat   1140

gggtgtttct gggtgggccg tcaggcatgg gcctgtgcaa cacagagccc gttcctcagg   1200

cgagtggtgc tgaggtgctc tgtggtgatg ggaacggcag aggctggcag gtgactgaac   1260

ttagcccagg gcagctccac atcctgggaa cactttcatg taaccccttc tagttttgaa   1320

ctctgcagca ggctggtgct gtgtagtggc cacccagtca ccacccttgg aagggtgtca   1380

gggtctgggc tcgcatgcac cctgctccct tctgccagcc tgcatcctct cctcaggcct   1440

ccttcccaca tcatctgtct tctctaagtt agggaaccat atttgagact ttcaaaaagg   1500

gaacttctag gtttaagctc ctcccagtag attcctgaac ccaattatca ggaaatcatc   1560

ctgagcactc acaggttcat ttaacactca ctcatcaagc accttcctat gtgctaggtg   1620

ctggggaaaa cttgaccaag gaagagttcc tgtcctgaag cttccaggac ccagctttcc   1680

ttttctggtg tggccttgta gctagtgcct gggcacaggt gtttttcttt ttgcagtttt   1740

acctagtgct gggagttcag ttctttttcc tctagaaaaa tacctctgtg ctccagagcc   1800

taatttttcc cagatgcata tttagctcta gggagaggac taggaggaaa tccccctccc   1860

tttagctgcc tgaactgact gaggcccact cactagagcc atgttcagtg ctactgtgat   1920

tagtagtaat taaatatgaa ctggtattct caagtaagca ttccttttgc tctctttaag   1980

acctcacaga ttctgacctt agattctgtg acaaactgat acaggagctg ggctggctat   2040

ggctttacca caacaagtag gtttgcttaa gaaattacta aacaatggct gggcgtggtg   2100

gctcactcct gtaatcccag cactttggga ggccgagatg ggcggatcac gaggtcagga   2160

gatcgagacc atcctggcta acagggtgaa accacgtctc tactaaaaat acaaaaaaat   2220

tagccaggcg tagtggtggg cgcctgtagt cccagctact tgggaggctg aggcaggaga   2280

atggcgtgaa cccgggaggc ggagcttgca gtgagccgag atcacgccac tgcactccag   2340

cctgggcgac agagcgagac tccgtctcaa aaaaaaaaaa gttactaaac aaggctgggc   2400

gtggtggctc acacctgtaa tcccagcact ttgggaggcc aaggaaggtg gatcacctga   2460

ggtcaggagt tcgagaccag cctggccaac atggtgaaac cccatcccta ctaaaaatac   2520

aaaaattagc tgggcgtggg tgcctgtaat cccagctact tctgaggctg aggcaggaga   2580

accgcttgaa cctgggaggc ggaggttgca gtgagccaat gtggcaccac tggactccag   2640

cctgggcaag agcaagactg tctcaaaaca aaaacaacaa acaaacaaac aaaaagaaaa   2700

cacaaaaaac attactaaac aagatttcta gagggaatta acaaaccagt gcttatttac   2760

caataaacta atacgctaat tgcaggaacc ctgattaaag caggcccctg ttaacacaag   2820

attcttagga tatacttgga aacaggtgca ttggaaacca ctgtactgag aagtttatgg   2880

gctcaagact gaattggaag ctaggcgtgg tcgctcatgc ctgtaatccc agcactctgg   2940

gaggctgagg tggaaggatg agttcaggag ttcgagacca gcctgggcaa cacagagaga   3000

cgtgtcttta aaaaagtaaa aaatgggctg agtgccttgg ctcatgcctg taatcccagc   3060

actttgggaa gccaaggcgg gtggatcact tcaggccagg agttcaagaa cagcctgacc   3120

aacatggcaa aactccatct ctactaaaaa taccaaaaaa attagcaggg tgtggtggtg   3180

cacacctgta gtcccagcta ctcaggaggc tgatgtgtga gaatcacttg aacct        3235


<210>  6030
<211>  329
<212>  PRT
<213>  Homosapiens

<400>  6030

Met Val Pro His Trp Asp Pro Lys Ile Ser Ala Ser Tyr Pro Arg Gly 
1               5                   10                  15      


Arg His Ser Pro Pro Asp Asp Leu Gly Ser Ser Phe Tyr Pro Glu Leu 
            20                  25                  30          


Gly Pro Tyr Ser Ser Arg Asp Pro Glu Val Leu Arg Glu His Met Thr 
        35                  40                  45              


Gln Leu Lys Glu Ala Ala Ile Gly Val Leu Val Leu Ser Trp Tyr Pro 
    50                  55                  60                  


Pro Gly Met Ala Asp Asp Asn Gly Glu Pro Ser Asp Asp Leu Val Pro 
65                  70                  75                  80  


Ala Ile Leu Asp Thr Ala His Gln Tyr Ser Ile Gln Val Ala Phe His 
                85                  90                  95      


Ile Gln Pro Tyr Lys Gly Arg Asp Asp Ile Thr Val His Asp Asn Ile 
            100                 105                 110         


Lys Tyr Ile Ile Asp Thr Tyr Gly Ser His Gly Ala Phe Tyr Arg Tyr 
        115                 120                 125             


Lys Asn Ser Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr Asp Ser 
    130                 135                 140                 


Tyr Leu Thr Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro Asn Gly 
145                 150                 155                 160 


Pro His Ser Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile Ala Leu 
                165                 170                 175     


Leu Val Glu Glu Gly His Thr His Asp Ile Leu Ala Ala Gly Phe Asp 
            180                 185                 190         


Gly Met Tyr Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser 
        195                 200                 205             


His Gln Asn Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn Leu 
    210                 215                 220                 


Met Phe Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg 
225                 230                 235                 240 


Pro Trp Asn Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr 
                245                 250                 255     


Glu Thr Ala Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile Val Ser 
            260                 265                 270         


Ile Thr Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala 
        275                 280                 285             


Ile Pro Lys Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His 
    290                 295                 300                 


Gln Pro Ser Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu His Phe 
305                 310                 315                 320 


Ile Lys Glu Lys Glu Gln Trp Leu Met 
                325                 


<210>  6031
<211>  3208
<212>  DNA
<213>  Homosapiens

<400>  6031
agtctaaagc ctggctccct tccggcctgg cgcgctacgg ttcccgcagg cgctccgctt     60

cagcaccgcg ggcgtggaca gctccggggc gcgaggctct gggactcatc tgcaggaagt    120

gaacctggca ggaggcttgc ttcaggtttt taggaaccat ttttgcaatt ggagatgttt    180

gtgaggaaaa aaatctctgt tgaggggggt actgtgtgtc tctgaagtgg cctctgtgtt    240

gcgtctcagg cgtcctggtc ctgtcctggt acccacctgg catggctgat gataacgggg    300

agccctcaga tgacctggtg cccgccattc tggacaccgc ccatcagtac agcatccagg    360

tatggctccc atggtgcatt ttaccgctat aagaacagca tgggcaagag cctcccactc    420

ttttatatct acgactcata cctgacgtcc cctgaggcct gggcccacct cctgacacca    480

aacgggcccc attcgatccg caacacgccc tacgatgggg tcttcatagc gctgctggtg    540

gaggagggcc acacccacga tatcctggcc gccggatttg acggcatgta cacctacttt    600

gcctccaatg gtttctcctt tggttcttcc catcagaact ggaaagctgt gaagaacttt    660

tgtgatgcca acaacctcat gttcatcccc agtgtggggc ctggctacat agacaccagc    720

attcggccct ggaacaacca caatacgcgc aacagggtca atggcaagta ctatgagacg    780

gccctgcagg cggccctgac agtgaggccc gagatcgttt ccattacctc cttcaatgag    840

tggcacgagg gcacccagat tgagaaggcc attcccaaga agacacccac ccgcctgtat    900

ttggactacc tgcctcacca gcccagcctg tacctggagc tgacacgccg ctgggcggag    960

cacttcatca aagagaagga gcagtggctc atgtgagggg cctgtaaatg ggcgtgaggt   1020

gctgatgtcc ttgccttgct ggaagatgtc accatgtggg gttcagctga ggttgtagcc   1080

actcactcgt tcccaggtca gaggtcagca gatgggtgtt tctgggtggg ccgtcaggca   1140

tgggcctgtg caacacagag cccgttcctc aggcgagtgg tgctgaggtg ctctgtggtg   1200

atgggaacgg cagaggctgg caggtgactg aacttagccc agggcagctc cacatcctgg   1260

gaacactttc atgtaacccc ttctagtttt gaactctgca gcaggctggt gctgtgtagt   1320

ggccacccag tcaccaccct tggaagggtg tcagggtctg ggctcgcatg caccctgctc   1380

ccttctgcca gcctgcatcc tctcctcagg cctccttccc acatcatctg tcttctctaa   1440

gttagggaac catatttgag actttcaaaa agggaacttc taggtttaag ctcctcccag   1500

tagattcctg aacccaatta tcaggaaatc atcctgagca ctcacaggtt catttaacac   1560

tcactcatca agcaccttcc tatgtgctag gtgctgggga aaacttgacc aaggaagagt   1620

tcctgtcctg aagcttccag gacccagctt tccttttctg gtgtggcctt gtagctagtg   1680

cctgggcaca ggtgtttttc tttttgcagt tttacctagt gctgggagtt cagttctttt   1740

tcctctagaa aaatacctct gtgctccaga gcctaatttt tcccagatgc atatttagct   1800

ctagggagag gactaggagg aaatccccct ccctttagct gcctgaactg actgaggccc   1860

actcactaga gccatgttca gtgctactgt gattagtagt aattaaatat gaactggtat   1920

tctcaagtaa gcattccttt tgctctcttt aagacctcac agattctgac cttagattct   1980

gtgacaaact gatacaggag ctgggctggc tatggcttta ccacaacaag taggtttgct   2040

taagaaatta ctaaacaatg gctgggcgtg gtggctcact cctgtaatcc cagcactttg   2100

ggaggccgag atgggcggat cacgaggtca ggagatcgag accatcctgg ctaacagggt   2160

gaaaccacgt ctctactaaa aatacaaaaa aattagccag gcgtagtggt gggcgcctgt   2220

agtcccagct acttgggagg ctgaggcagg agaatggcgt gaacccggga ggcggagctt   2280

gcagtgagcc gagatcacgc cactgcactc cagcctgggc gacagagcga gactccgtct   2340

caaaaaaaaa aaagttacta aacaaggctg ggcgtggtgg ctcacacctg taatcccagc   2400

actttgggag gccaaggaag gtggatcacc tgaggtcagg agttcgagac cagcctggcc   2460

aacatggtga aaccccatcc ctactaaaaa tacaaaaatt agctgggcgt gggtgcctgt   2520

aatcccagct acttctgagg ctgaggcagg agaaccgctt gaacctggga ggcggaggtt   2580

gcagtgagcc aatgtggcac cactggactc cagcctgggc aagagcaaga ctgtctcaaa   2640

acaaaaacaa caaacaaaca aacaaaaaga aaacacaaaa aacattacta aacaagattt   2700

ctagagggaa ttaacaaacc agtgcttatt taccaataaa ctaatacgct aattgcagga   2760

accctgatta aagcaggccc ctgttaacac aagattctta ggatatactt ggaaacaggt   2820

gcattggaaa ccactgtact gagaagttta tgggctcaag actgaattgg aagctaggcg   2880

tggtcgctca tgcctgtaat cccagcactc tgggaggctg aggtggaagg atgagttcag   2940

gagttcgaga ccagcctggg caacacagag agacgtgtct ttaaaaaagt aaaaaatggg   3000

ctgagtgcct tggctcatgc ctgtaatccc agcactttgg gaagccaagg cgggtggatc   3060

acttcaggcc aggagttcaa gaacagcctg accaacatgg caaaactcca tctctactaa   3120

aaataccaaa aaaattagca gggtgtggtg gtgcacacct gtagtcccag ctactcagga   3180

ggctgatgtg tgagaatcac ttgaacct                                      3208


<210>  6032
<211>  235
<212>  PRT
<213>  Homosapiens

<400>  6032

Met Ile Thr Gly Ser Pro Gln Met Thr Trp Cys Pro Pro Phe Trp Thr 
1               5                   10                  15      


Pro Pro Ile Ser Thr Ala Ser Arg Tyr Gly Ser His Gly Ala Phe Tyr 
            20                  25                  30          


Arg Tyr Lys Asn Ser Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr 
        35                  40                  45              


Asp Ser Tyr Leu Thr Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro 
    50                  55                  60                  


Asn Gly Pro His Ser Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile 
65                  70                  75                  80  


Ala Leu Leu Val Glu Glu Gly His Thr His Asp Ile Leu Ala Ala Gly 
                85                  90                  95      


Phe Asp Gly Met Tyr Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly 
            100                 105                 110         


Ser Ser His Gln Asn Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn 
        115                 120                 125             


Asn Leu Met Phe Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser 
    130                 135                 140                 


Ile Arg Pro Trp Asn Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys 
145                 150                 155                 160 


Tyr Tyr Glu Thr Ala Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile 
                165                 170                 175     


Val Ser Ile Thr Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu 
            180                 185                 190         


Lys Ala Ile Pro Lys Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu 
        195                 200                 205             


Pro His Gln Pro Ser Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu 
    210                 215                 220                 


His Phe Ile Lys Glu Lys Glu Gln Trp Leu Met 
225                 230                 235 


<210>  6033
<211>  779
<212>  DNA
<213>  Homosapiens

<400>  6033
gtatggctcc catggtgcat tttaccgcta taagaacagc atgggcaaga gcctcccact     60

cttttatatc tacgactcat acctgacgtc ccctgaggcc tgggcccacc tcctgacacc    120

aaacgggccc cattcgatcc gcaacacgcc ctacgatggg gtcttcatag cgctgctggt    180

ggaggagggc cacacccacg atatcctggc cgccggattt gacggcatgt acacctactt    240

tgcctccaat ggtttctcct ttggttcttc ccatcagaac tggaaagctg tgaagaactt    300

ttgtgatgcc aacaacctca tgttcatccc cagtgtgggg cctggctaca tagacaccag    360

cattcggccc tggaacaacc acaatacgcg caacagggtc aatggcaagt actatgagac    420

ggccctgcag gcggccctga cagtgaggcc cgagatcgtt tccattacct ccttcaatga    480

gtggcacgag ggcacccaga ttgagaaggc cattcccaag aagacaccca cccgcctgta    540

tttggactac ctgcctcacc agcccagcct gtacctggag ctgacacgcc gctgggcgga    600

gcacttcatc aaagagaagg agcagtggct catgtgaggg gcctgtaaat gggcgtgagg    660

tgctgatgtc cttgccttgc tggaagatgt caccatgtgg ggttcagctg aggttgtagc    720

catcactaga gccatgttca gtgctactgt gattagtagt aattaaatat gaactggta     779


<210>  6034
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  6034

Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr Asp Ser Tyr Leu Thr 
1               5                   10                  15      


Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro Asn Gly Pro His Ser 
            20                  25                  30          


Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile Ala Leu Leu Val Glu 
        35                  40                  45              


Glu Gly His Thr His Asp Ile Leu Ala Ala Gly Phe Asp Gly Met Tyr 
    50                  55                  60                  


Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser His Gln Asn 
65                  70                  75                  80  


Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn Leu Met Phe Ile 
                85                  90                  95      


Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg Pro Trp Asn 
            100                 105                 110         


Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr Glu Thr Ala 
        115                 120                 125             


Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile Val Ser Ile Thr Ser 
    130                 135                 140                 


Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala Ile Pro Lys 
145                 150                 155                 160 


Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His Gln Pro Ser 
                165                 170                 175     


Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu His Phe Ile Lys Glu 
            180                 185                 190         


Lys Glu Gln Trp Leu Met 
        195             


<210>  6035
<211>  1468
<212>  DNA
<213>  Homosapiens

<400>  6035
gtatggctcc catggtgcat tttaccgcta taagaacagc atgggcaaga gcctcccact     60

cttttatatc tacgactcat acctgacgtc ccctgaggcc tgggcccacc tcctgacacc    120

aaacgggccc cattcgatcc gcaacacgcc ctacgatggg gtcttcatag cgctgctggt    180

ggaggagggc cacacccacg atatcctggc cgccggattt gacggcatgt acacctactt    240

tgcctccaat ggtttctcct ttggttcttc ccatcagaac tggaaagctg tgaagaactt    300

ttgtgatgcc aacaacctca tgttcatccc cagtgtgggg cctggctaca tagacaccag    360

cattcggccc tggaacaacc acaatacgcg caacagggtc aatggcaagt actatgagac    420

ggccctgcag gcggccctga cagtgaggcc cgagatcgtt tccattacct ccttcaatga    480

gtggcacgag ggcacccaga ttgagaaggc cattcccaag aagacaccca cccgcctgta    540

tttggactac ctgcctcacc agcccagcct gtacctggag ctgacacgcc gctgggcgga    600

gcacttcatc aaagagaagg agcagtggct catgtgaggg gcctgtaaat gggcgtgagg    660

tgctgatgtc cttgccttgc tggaagatgt caccatgtgg ggttcagctg aggttgtagc    720

cactcactcg ttcccaggtc agaggtcagc agatgggtgt ttctgggtgg gccgtcaggc    780

atgggcctgt gcaacacaga gcccgttcct caggcgagtg gtgctgaggt gctctgtggt    840

gatgggaacg gcagaggctg gcaggtgact gaacttagcc cagggcagct ccacatcctg    900

ggaacacttt catgtaaccc cttctagttt tgaactctgc atcctctcct caggcctcct    960

tcccacatca tctgtcttct ctaagttagg gaaccatatt tgagactttc aaaaagggaa   1020

cttctaggtt taagctcctc ccagtagatt cctgaaccca attatcagga aatcatcctg   1080

agcactcaca ggttcattta acactcactc atcaagcacc ttcctatgtg ctaggtgctg   1140

gggaaaactt gaccaaggaa gagttcctgt cctgaagctt ccaggaccca gctttccttt   1200

tctggtgtgg ccttgtagct agtgcctggg cacaggtgtt tttctttttg cagttttacc   1260

tagtgctggg agttcagttc tttttcctct agaaaaatac ctctgtgctc cagagcctaa   1320

tttttcccag atgcatattt agctctaggg agaggactag gaggaaatcc ccctcccttt   1380

agctgcctga actgactgag gcccactcac tagagccatg ttcagtgcta ctgtgattag   1440

tagtaattaa atatgaactg gtattctc                                      1468


<210>  6036
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  6036

Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr Asp Ser Tyr Leu Thr 
1               5                   10                  15      


Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro Asn Gly Pro His Ser 
            20                  25                  30          


Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile Ala Leu Leu Val Glu 
        35                  40                  45              


Glu Gly His Thr His Asp Ile Leu Ala Ala Gly Phe Asp Gly Met Tyr 
    50                  55                  60                  


Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser His Gln Asn 
65                  70                  75                  80  


Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn Leu Met Phe Ile 
                85                  90                  95      


Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg Pro Trp Asn 
            100                 105                 110         


Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr Glu Thr Ala 
        115                 120                 125             


Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile Val Ser Ile Thr Ser 
    130                 135                 140                 


Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala Ile Pro Lys 
145                 150                 155                 160 


Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His Gln Pro Ser 
                165                 170                 175     


Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu His Phe Ile Lys Glu 
            180                 185                 190         


Lys Glu Gln Trp Leu Met 
        195             


<210>  6037
<211>  1105
<212>  DNA
<213>  Homosapiens

<400>  6037
gtatggctcc catggtgcat tttaccgcta taagaacagc atgggcaaga gcctcccact     60

cttttatatc tacgactcat acctgacgtc ccctgaggcc tgggcccacc tcctgacacc    120

aaacgggccc cattcgatcc gcaacacgcc ctacgatggg gtcttcatag cgctgctggt    180

ggaggagggc cacacccacg atatcctggc cgccggattt gacggcatgt acacctactt    240

tgcctccaat ggtttctcct ttggttcttc ccatcagaac tggaaagctg tgaagaactt    300

ttgtgatgcc aacaacctca tgttcatccc cagtgtgggg cctggctaca tagacaccag    360

cattcggccc tggaacaacc acaatacgcg caacagggtc aatggcaagt actatgagac    420

ggccctgcag gcggccctga cagtgaggcc cgagatcgtt tccattacct ccttcaatga    480

gtggcacgag ggcacccaga ttgagaaggc cattcccaag aagacaccca cccgcctgta    540

tttggactac ctgcctcacc agcccagcct gtacctggag ctgacacgcc gctgggcgga    600

gcaatcatct gtcttctcta agttagggaa ccatatttga gactttcaaa aagggaactt    660

ctaggtttaa gctcctccca gtagattcct gaacccaatt atcaggaaat catcctgagc    720

actcacaggt tcatttaaca ctcactcatc aagcaccttc ctatgtgcta ggtgctgggg    780

aaaacttgac caaggaagag ttcctgtcct gaagcttcca ggacccagct ttccttttct    840

ggtgtggcct tgtagctagt gcctgggcac aggtgttttt ctttttgcag ttttacctag    900

tgctgggagt tcagttcttt ttcctctaga aaaatacctc tgtgctccag agcctaattt    960

ttcccagatg catatttagc tctagggaga ggactaggag gaaatccccc tccctttagc   1020

tgcctgaact gactgaggcc cactcactag agccatgttc agtgctactg tgattagtag   1080

taattaaata tgaactggta ttctc                                         1105


<210>  6038
<211>  199
<212>  PRT
<213>  Homosapiens

<400>  6038

Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr Asp Ser Tyr Leu Thr 
1               5                   10                  15      


Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro Asn Gly Pro His Ser 
            20                  25                  30          


Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile Ala Leu Leu Val Glu 
        35                  40                  45              


Glu Gly His Thr His Asp Ile Leu Ala Ala Gly Phe Asp Gly Met Tyr 
    50                  55                  60                  


Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser His Gln Asn 
65                  70                  75                  80  


Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn Leu Met Phe Ile 
                85                  90                  95      


Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg Pro Trp Asn 
            100                 105                 110         


Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr Glu Thr Ala 
        115                 120                 125             


Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile Val Ser Ile Thr Ser 
    130                 135                 140                 


Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala Ile Pro Lys 
145                 150                 155                 160 


Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His Gln Pro Ser 
                165                 170                 175     


Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu Gln Ser Ser Val Phe 
            180                 185                 190         


Ser Lys Leu Gly Asn His Ile 
        195                 


<210>  6039
<211>  2752
<212>  DNA
<213>  Homosapiens

<400>  6039
gtatggctcc catggtgcat tttaccgcta taagaacagc atgggcaaga gcctcccact     60

cttttatatc tacgactcat acctgacgtc ccctgaggcc tgggcccacc tcctgacacc    120

aaacgggccc cattcgatcc gcaacacgcc ctacgatggg gtcttcatag cgctgctggt    180

ggaggagggc cacacccacg atatcctggc cgccggattt gacggcatgt acacctactt    240

tgcctccaat ggtttctcct ttggttcttc ccatcagaac tggaaagctg tgaagaactt    300

ttgtgatgcc aacaacctca tgttcatccc cagtgtgggg cctggctaca tagacaccag    360

cattcggccc tggaacaacc acaatacgcg caacagggtc aatggcaagt actatgagac    420

ggccctgcag gcggccctga cagtgaggcc cgagatcgtt tccattacct ccttcaatga    480

gtggcacgag ggcacccaga ttgagaaggc cattcccaag aagacaccca cccgcctgta    540

tttggactac ctgcctcacc agcccagcct gtacctggag ctgacacgcc gctgggcgga    600

gcacttcatc aaagagaagg agcagtggct catgtgaggg gcctgtaaat gggcgtgagg    660

tgctgatgtc cttgccttgc tggaagatgt caccatgtgg ggttcagctg aggttgtagc    720

cactcactcg ttcccaggtc agaggtcagc agatgggtgt ttctgggtgg gccgtcaggc    780

atgggcctgt gcaacacaga gcccgttcct caggcgagtg gtgctgaggt gctctgtggt    840

gatgggaacg gcagaggctg gcaggtgact gaacttagcc cagggcagct ccacatcctg    900

ggaacacttt catgtaaccc cttctagttt tgaactctgc atcctctcct caggcctcct    960

tcccacatca tctgtcttct ctaagttagg gaaccatatt tgagactttc aaaaagggaa   1020

cttctaggtt taagctcctc ccagtagatt cctgaaccca attatcagga aatcatcctg   1080

agcactcaca ggttcattta acactcactc atcaagcacc ttcctatgtg ctaggtgctg   1140

gggaaaactt gaccaaggaa gagttcctgt cctgaagctt ccaggaccca gctttccttt   1200

tctggtgtgg ccttgtagct agtgcctggg cacaggtgtt tttctttttg cagttttacc   1260

tagtgctggg agttcagttc tttttcctct agaaaaatac ctctgtgctc cagagcctaa   1320

tttttcccag atgcatattt agctctaggg agaggactag gaggaaatcc ccctcccttt   1380

agctgcctga actgactgag gcccactcac tagagccatg ttcagtgcta ctgtgattag   1440

tagtaattaa atatgaactg gtattctcaa gtaagcattc cttttgctct ctttaagacc   1500

tcacagattc tgaccttaga ttctgtgaca aactgataca ggagctgggc tggctatggc   1560

tttaccacaa caagtaggtt tgcttaagaa attactaaac aatggctggg cgtggtggct   1620

cactcctgta atcccagcac tttgggaggc cgagatgggc ggatcacgag gtcaggagat   1680

cgagaccatc ctggctaaca gggtgaaacc acgtctctac taaaaataca aaaaaattag   1740

ccaggcgtag tggtgggcgc ctgtagtccc agctacttgg gaggctgagg caggagaatg   1800

gcgtgaaccc gggaggcgga gcttgcagtg agccgagatc acgccactgc actccagcct   1860

gggcgacaga gcgagactcc gtctcaaaaa aaaaaaagtt actaaacaag gctgggcgtg   1920

gtggctcaca cctgtaatcc cagcactttg ggaggccaag gaaggtggat cacctgaggt   1980

caggagttcg agaccagcct ggccaacatg gtgaaacccc atccctacta aaaatacaaa   2040

aattagctgg gcgtgggtgc ctgtaatccc agctacttct gaggctgagg caggagaacc   2100

gcttgaacct gggaggcgga ggttgcagtg agccaatgtg gcaccactgg actccagcct   2160

gggcaagagc aagactgtct caaaacaaaa acaacaaaca aacaaacaaa aagaaaacac   2220

aaaaaacatt actaaacaag atttctagag ggaattaaca aaccagtgct tatttaccaa   2280

taaactaata cgctaattgc aggaaccctg attaaagcag gcccctgtta acacaagatt   2340

cttaggatat acttggaaac aggtgcattg gaaaccactg tactgagaag tttatgggct   2400

caagactgaa ttggaagcta ggcgtggtcg ctcatgcctg taatcccagc actctgggag   2460

gctgaggtgg aaggatgagt tcaggagttc gagaccagcc tgggcaacac agagagacgt   2520

gtctttaaaa aagtaaaaaa tgggctgagt gccttggctc atgcctgtaa tcccagcact   2580

ttgggaagcc aaggcgggtg gatcacttca ggccaggagt tcaagaacag cctgaccaac   2640

atggcaaaac tccatctcta ctaaaaatac caaaaaaatt agcagggtgt ggtggtgcac   2700

acctgtagtc ccagctactc aggaggctga tgtgtgagaa tcacttgaac ct           2752


<210>  6040
<211>  198
<212>  PRT
<213>  Homosapiens

<400>  6040

Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr Asp Ser Tyr Leu Thr 
1               5                   10                  15      


Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro Asn Gly Pro His Ser 
            20                  25                  30          


Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile Ala Leu Leu Val Glu 
        35                  40                  45              


Glu Gly His Thr His Asp Ile Leu Ala Ala Gly Phe Asp Gly Met Tyr 
    50                  55                  60                  


Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser His Gln Asn 
65                  70                  75                  80  


Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn Leu Met Phe Ile 
                85                  90                  95      


Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg Pro Trp Asn 
            100                 105                 110         


Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr Glu Thr Ala 
        115                 120                 125             


Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile Val Ser Ile Thr Ser 
    130                 135                 140                 


Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala Ile Pro Lys 
145                 150                 155                 160 


Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His Gln Pro Ser 
                165                 170                 175     


Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu His Phe Ile Lys Glu 
            180                 185                 190         


Lys Glu Gln Trp Leu Met 
        195             


<210>  6041
<211>  2389
<212>  DNA
<213>  Homosapiens

<400>  6041
gtatggctcc catggtgcat tttaccgcta taagaacagc atgggcaaga gcctcccact     60

cttttatatc tacgactcat acctgacgtc ccctgaggcc tgggcccacc tcctgacacc    120

aaacgggccc cattcgatcc gcaacacgcc ctacgatggg gtcttcatag cgctgctggt    180

ggaggagggc cacacccacg atatcctggc cgccggattt gacggcatgt acacctactt    240

tgcctccaat ggtttctcct ttggttcttc ccatcagaac tggaaagctg tgaagaactt    300

ttgtgatgcc aacaacctca tgttcatccc cagtgtgggg cctggctaca tagacaccag    360

cattcggccc tggaacaacc acaatacgcg caacagggtc aatggcaagt actatgagac    420

ggccctgcag gcggccctga cagtgaggcc cgagatcgtt tccattacct ccttcaatga    480

gtggcacgag ggcacccaga ttgagaaggc cattcccaag aagacaccca cccgcctgta    540

tttggactac ctgcctcacc agcccagcct gtacctggag ctgacacgcc gctgggcgga    600

gcaatcatct gtcttctcta agttagggaa ccatatttga gactttcaaa aagggaactt    660

ctaggtttaa gctcctccca gtagattcct gaacccaatt atcaggaaat catcctgagc    720

actcacaggt tcatttaaca ctcactcatc aagcaccttc ctatgtgcta ggtgctgggg    780

aaaacttgac caaggaagag ttcctgtcct gaagcttcca ggacccagct ttccttttct    840

ggtgtggcct tgtagctagt gcctgggcac aggtgttttt ctttttgcag ttttacctag    900

tgctgggagt tcagttcttt ttcctctaga aaaatacctc tgtgctccag agcctaattt    960

ttcccagatg catatttagc tctagggaga ggactaggag gaaatccccc tccctttagc   1020

tgcctgaact gactgaggcc cactcactag agccatgttc agtgctactg tgattagtag   1080

taattaaata tgaactggta ttctcaagta agcattcctt ttgctctctt taagacctca   1140

cagattctga ccttagattc tgtgacaaac tgatacagga gctgggctgg ctatggcttt   1200

accacaacaa gtaggtttgc ttaagaaatt actaaacaat ggctgggcgt ggtggctcac   1260

tcctgtaatc ccagcacttt gggaggccga gatgggcgga tcacgaggtc aggagatcga   1320

gaccatcctg gctaacaggg tgaaaccacg tctctactaa aaatacaaaa aaattagcca   1380

ggcgtagtgg tgggcgcctg tagtcccagc tacttgggag gctgaggcag gagaatggcg   1440

tgaacccggg aggcggagct tgcagtgagc cgagatcacg ccactgcact ccagcctggg   1500

cgacagagcg agactccgtc tcaaaaaaaa aaaagttact aaacaaggct gggcgtggtg   1560

gctcacacct gtaatcccag cactttggga ggccaaggaa ggtggatcac ctgaggtcag   1620

gagttcgaga ccagcctggc caacatggtg aaaccccatc cctactaaaa atacaaaaat   1680

tagctgggcg tgggtgcctg taatcccagc tacttctgag gctgaggcag gagaaccgct   1740

tgaacctggg aggcggaggt tgcagtgagc caatgtggca ccactggact ccagcctggg   1800

caagagcaag actgtctcaa aacaaaaaca acaaacaaac aaacaaaaag aaaacacaaa   1860

aaacattact aaacaagatt tctagaggga attaacaaac cagtgcttat ttaccaataa   1920

actaatacgc taattgcagg aaccctgatt aaagcaggcc cctgttaaca caagattctt   1980

aggatatact tggaaacagg tgcattggaa accactgtac tgagaagttt atgggctcaa   2040

gactgaattg gaagctaggc gtggtcgctc atgcctgtaa tcccagcact ctgggaggct   2100

gaggtggaag gatgagttca ggagttcgag accagcctgg gcaacacaga gagacgtgtc   2160

tttaaaaaag taaaaaatgg gctgagtgcc ttggctcatg cctgtaatcc cagcactttg   2220

ggaagccaag gcgggtggat cacttcaggc caggagttca agaacagcct gaccaacatg   2280

gcaaaactcc atctctacta aaaataccaa aaaaattagc agggtgtggt ggtgcacacc   2340

tgtagtccca gctactcagg aggctgatgt gtgagaatca cttgaacct               2389


<210>  6042
<211>  199
<212>  PRT
<213>  Homosapiens

<400>  6042

Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr Asp Ser Tyr Leu Thr 
1               5                   10                  15      


Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro Asn Gly Pro His Ser 
            20                  25                  30          


Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile Ala Leu Leu Val Glu 
        35                  40                  45              


Glu Gly His Thr His Asp Ile Leu Ala Ala Gly Phe Asp Gly Met Tyr 
    50                  55                  60                  


Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser His Gln Asn 
65                  70                  75                  80  


Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn Leu Met Phe Ile 
                85                  90                  95      


Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg Pro Trp Asn 
            100                 105                 110         


Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr Glu Thr Ala 
        115                 120                 125             


Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile Val Ser Ile Thr Ser 
    130                 135                 140                 


Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala Ile Pro Lys 
145                 150                 155                 160 


Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His Gln Pro Ser 
                165                 170                 175     


Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu Gln Ser Ser Val Phe 
            180                 185                 190         


Ser Lys Leu Gly Asn His Ile 
        195                 


<210>  6043
<211>  1061
<212>  DNA
<213>  Homosapiens

<400>  6043
aacacgccct acgatggggt cttcatagcg ctgctggtgg aggagggcca cacccacgat     60

atcctggccg ccggatttga cggcatgtac acctactttg cctccaatgg tttctccttt    120

ggttcttccc atcagaactg gaaagctgtg aagaactttt gtgatgccaa caaccacaat    180

acgcgcaaca gggtcaatgg caagtactat gagacggccc tgcaggcggc cctgacagtg    240

aggcccgaga tcgtttccat tacctccttc aatgagtggc acgagggcac ccagattgag    300

aaggccattc ccaagaagac acccacccgc ctgtatttgg actacctgcc tcaccagccc    360

agcctgtacc tggagctgac acgccgctgg gcggagcact tcatcaaaga gaaggagcag    420

tggctcatgt gaggggcctg taaatgggcg tgaggtgctg atgtccttgc cttgctggaa    480

gatggtgtca gggtctgggc tcgcatgcac cctgctccct tctgccagcc tgcatcctct    540

cctcaggcct ccttcccaca tcatctgtct tctctaagtt agggaaccat atttgagact    600

ttcaaaaagg gaacttctag gtttaagctc ctcccagtag attcctgaac ccaattatca    660

ggaaatcatc ctgagcactc acaggttcat ttaacactca ctcatcaagc accttcctat    720

gtgctaggtg ctggggaaaa cttgaccaag gaagagttcc tgtcctgaag cttccaggac    780

ccagctttcc ttttctggtg tggccttgta gctagtgcct gggcacaggt gtttttcttt    840

ttgcagtttt acctagtgct gggagttcag ttctttttcc tctagaaaaa tacctctgtg    900

ctccagagcc taatttttcc cagatgcata tttagctcta gggagaggac taggaggaaa    960

tccccctccc tttagctgcc tgaactgact gaggcccact cactagagcc atgttcagtg   1020

ctactgtgat tagtagtaat taaatatgaa ctggtattct c                       1061


<210>  6044
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  6044

Met Tyr Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser His 
1               5                   10                  15      


Gln Asn Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn His Asn 
            20                  25                  30          


Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr Glu Thr Ala Leu Gln Ala 
        35                  40                  45              


Ala Leu Thr Val Arg Pro Glu Ile Val Ser Ile Thr Ser Phe Asn Glu 
    50                  55                  60                  


Trp His Glu Gly Thr Gln Ile Glu Lys Ala Ile Pro Lys Lys Thr Pro 
65                  70                  75                  80  


Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His Gln Pro Ser Leu Tyr Leu 
                85                  90                  95      


Glu Leu Thr Arg Arg Trp Ala Glu His Phe Ile Lys Glu Lys Glu Gln 
            100                 105                 110         


Trp Leu Met 
        115 


<210>  6045
<211>  2324
<212>  DNA
<213>  Homosapiens

<400>  6045
ttcatagcgc tgctggtgga ggagggccac acccacgata tcctggccgc cggatttgac     60

ggcatgtaca cctactttgc ctccaatggt ttctcctttg gttcttccca tcagaactgg    120

aaagctgtga agaacttttg tgatgccaac aaccacaata cgcgcaacag ggtcaatggc    180

aagtactatg agacggccct gcaggcggcc ctgacagtga ggcccgagat cgtttccatt    240

acctccttca atgagtggca cgagggcacc cagattgaga aggccattcc caagaagaca    300

cccacccgcc tgtatttgga ctacctgcct caccagccca gcctgtacct ggagctgaca    360

cgccgctggg cggagcactt catcaaagag aaggagcagt ggctcatgtg aggggcctgt    420

aaatgggcgt gaggtgctga tgtccttgcc ttgctggaag atggtgtcag ggtctgggct    480

cgcatgcacc ctgctccctt ctgccagcct gcatcctctc ctcaggcctc cttcccacat    540

catctgtctt ctctaagtta gggaaccata tttgagactt tcaaaaaggg aacttctagg    600

tttaagctcc tcccagtaga ttcctgaacc caattatcag gaaatcatcc tgagcactca    660

caggttcatt taacactcac tcatcaagca ccttcctatg tgctaggtgc tggggaaaac    720

ttgaccaagg aagagttcct gtcctgaagc ttccaggacc cagctttcct tttctggtgt    780

ggccttgtag ctagtgcctg ggcacaggtg tttttctttt tgcagtttta cctagtgctg    840

ggagttcagt tctttttcct ctagaaaaat acctctgtgc tccagagcct aatttttccc    900

agatgcatat ttagctctag ggagaggact aggaggaaat ccccctccct ttagctgcct    960

gaactgactg aggcccactc actagagcca tgttcagtgc tactgtgatt agtagtaatt   1020

aaatatgaac tggtattctc aagtaagcat tccttttgct ctctttaaga cctcacagat   1080

tctgacctta gattctgtga caaactgata caggagctgg gctggctatg gctttaccac   1140

aacaagtagg tttgcttaag aaattactaa acaatggctg ggcgtggtgg ctcactcctg   1200

taatcccagc actttgggag gccgagatgg gcggatcacg aggtcaggag atcgagacca   1260

tcctggctaa cagggtgaaa ccacgtctct actaaaaata caaaaaaatt agccaggcgt   1320

agtggtgggc gcctgtagtc ccagctactt gggaggctga ggcaggagaa tggcgtgaac   1380

ccgggaggcg gagcttgcag tgagccgaga tcacgccact gcactccagc ctgggcgaca   1440

gagcgagact ccgtctcaaa aaaaaaaaag ttactaaaca aggctgggcg tggtggctca   1500

cacctgtaat cccagcactt tgggaggcca aggaaggtgg atcacctgag gtcaggagtt   1560

cgagaccagc ctggccaaca tggtgaaacc ccatccctac taaaaataca aaaattagct   1620

gggcgtgggt gcctgtaatc ccagctactt ctgaggctga ggcaggagaa ccgcttgaac   1680

ctgggaggcg gaggttgcag tgagccaatg tggcaccact ggactccagc ctgggcaaga   1740

gcaagactgt ctcaaaacaa aaacaacaaa caaacaaaca aaaagaaaac acaaaaaaca   1800

ttactaaaca agatttctag agggaattaa caaaccagtg cttatttacc aataaactaa   1860

tacgctaatt gcaggaaccc tgattaaagc aggcccctgt taacacaaga ttcttaggat   1920

atacttggaa acaggtgcat tggaaaccac tgtactgaga agtttatggg ctcaagactg   1980

aattggaagc taggcgtggt cgctcatgcc tgtaatccca gcactctggg aggctgaggt   2040

ggaaggatga gttcaggagt tcgagaccag cctgggcaac acagagagac gtgtctttaa   2100

aaaagtaaaa aatgggctga gtgccttggc tcatgcctgt aatcccagca ctttgggaag   2160

ccaaggcggg tggatcactt caggccagga gttcaagaac agcctgacca acatggcaaa   2220

actccatctc tactaaaaat accaaaaaaa ttagcagggt gtggtggtgc acacctgtag   2280

tcccagctac tcaggaggct gatgtgtgag aatcacttga acct                    2324


<210>  6046
<211>  115
<212>  PRT
<213>  Homosapiens

<400>  6046

Met Tyr Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser His 
1               5                   10                  15      


Gln Asn Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn His Asn 
            20                  25                  30          


Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr Glu Thr Ala Leu Gln Ala 
        35                  40                  45              


Ala Leu Thr Val Arg Pro Glu Ile Val Ser Ile Thr Ser Phe Asn Glu 
    50                  55                  60                  


Trp His Glu Gly Thr Gln Ile Glu Lys Ala Ile Pro Lys Lys Thr Pro 
65                  70                  75                  80  


Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His Gln Pro Ser Leu Tyr Leu 
                85                  90                  95      


Glu Leu Thr Arg Arg Trp Ala Glu His Phe Ile Lys Glu Lys Glu Gln 
            100                 105                 110         


Trp Leu Met 
        115 


<210>  6047
<211>  895
<212>  DNA
<213>  Homosapiens

<400>  6047
ctccttcaat gagtggcacg agggcaccca gattgagaag gccattccca agaagacacc     60

cacccgcctg tatttggact acctgcctca ccagcccagc ctgtacctgg agctgacacg    120

ccgctgggcg gagcacttca tcaaagagaa ggagcagtgg ctcatgtgag gggcctgtaa    180

atgggcgtga ggtgctgatg tccttgcctt gctggaagat gtcaccatgt ggggttcagc    240

tgaggttgta gccactcact cgttcccagg tcagaggtca gcagatgggt gtttctgggt    300

gggccgtcag gcatgggcct gtgcaacaca gagcccgttc ctcaggcgag tggtgctgag    360

gtgctctgtg gtgatgggaa cggcagaggc tggcaggtga ctgaacttag cccagggcag    420

ctccacatcc tgggaacact ttcatgtaac cccttctagt tttgaactct gcagcaggct    480

ggtgctgtgt agaaatcatc ctgagcactc acaggttcat ttaacactca ctcatcaagc    540

accttcctat gtgctaggtg ctggggaaaa cttgaccaag gaagagttcc tgtcctgaag    600

cttccaggac ccagctttcc ttttctggtg tggccttgta gctagtgcct gggcacaggt    660

gtttttcttt ttgcagtttt acctagtgct gggagttcag ttctttttcc tctagaaaaa    720

tacctctgtg ctccagagcc taatttttcc cagatgcata tttagctcta gggagaggac    780

taggaggaaa tccccctccc tttagctgcc tgaactgact gaggcccact cactagagcc    840

atgttcagtg ctactgtgat tagtagtaat taaatatgaa ctggtattct caagt         895


<210>  6048
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  6048

Met Trp Gly Ser Ala Glu Val Val Ala Thr His Ser Phe Pro Gly Gln 
1               5                   10                  15      


Arg Ser Ala Asp Gly Cys Phe Trp Val Gly Arg Gln Ala Trp Ala Cys 
            20                  25                  30          


Ala Thr Gln Ser Pro Phe Leu Arg Arg Val Val Leu Arg Cys Ser Val 
        35                  40                  45              


Val Met Gly Thr Ala Glu Ala Gly Arg 
    50                  55          


<210>  6049
<211>  1845
<212>  DNA
<213>  Homosapiens

<400>  6049
tcccggaagc gggcctgggc ggatgtctcc ggcgcgtcgg tgcaggggga tgagggccgc     60

ggtggctgcc agcgtggggt tgagcgaggg gcctgctggc tcccggagcg gtcgcctctt    120

ccgcccgccg agtcccgctc cggcggcccc cggcgcccgg ctgttgcggc tcccggggag    180

cggggccgtg caggccgcga gcccggagcg cgccggctgg accgaggcgc tgcgggccgc    240

cgtggccgag ctgcgcgccg gcgccgtggt ggccgtcccc accgatacgc tgtacggcct    300

ggcctgcgcg gcgagctgct cggcggctct gcgcgctgtg taccgcctca agggtcgcag    360

cgaggccaag cctctggccg tatgcctcgg ccgcgtggcc gacgtctaca gatactgccg    420

tgtgagagta cctgaggggc tcctgaaaga cctactgcca ggaccagtga ccctggtgat    480

ggaacgctcg gaggagctca acaaggacct aaaccctttt acgcctcttg taggcattcg    540

gattcctgat catgctttta tgcaagactt ggctcagatg tttgagggtc cgcttgctct    600

cactagtgcc aacctcagct cccaggccag ttctctgaat gtcgaggagt tccaggatct    660

ctggcctcag ttgtccttgg ttattgatgg gggacaaatt ggggatggcc agagccccga    720

gtgtcgcctt ggctcaactg tggttgattt gtctgtgccc ggaaagtttg gcatcattcg    780

tccaggctgt gccctggaaa gtactacagc catcctccaa cagaagtacg gactgctccc    840

ctcacatgcg tcctacctgt gaaactctgg gaagcaggaa ggcccaagac ctggtgctgg    900

atactatgtg tctgtccact gacgactgtc aaggcctcat ttgcagaggc caccggagct    960

agggcactag cctgactttt aaggcagtgt gtctttctga gcactgtaga ccaagccctt   1020

ggagctgctg gtttagcctt gcacctgggg aaaggatgta tttatttgta ttttcatata   1080

tcagccaaaa gctgaatgga aaagttaaga acattcctag gtggccttat tctaataagt   1140

ttcttctgtc tgttttgttt ttcaattgaa aagtaattaa ataacagatt tagaatctag   1200

tgagagcctc ctctctggtg ggtggtggca tttaaggttc aaaccagcca gaagtgctgg   1260

tgctgtttaa aaagtctcag gtggctgcgt gtggtggctc atgcctgtaa tcccaacatt   1320

ctgggaggcc caggcgggag aactgcttga gcccaggagt tcagaatcag cctgggcaac   1380

atagcaatac tccgtctcat aaaaattaat aaataaaaag tctcaggtga ccaaaggctc   1440

ctgaagctag aaccaggttt ggataaagat tgaagagcca caggccactc ttccctctga   1500

gccattgggc ctagtggtgt catgtattgt aattgctcgc agggagagca gtctttttgg   1560

tgtaatagtg ggatgtctgc ttagttggca ggggttcagt ccaaatggaa gaatattggg   1620

aaataaacct ccactatcct ttatagccag ggactttttt cttatttatt cataaaataa   1680

attatagtta attataccca taacaccttt atttaaatcc agtgttctcc gcagcctttt   1740

gtctatttat atgtgtacca agtgttaaac ataattatta ttgggcattt gaactttgtt   1800

tttctttaaa gaaatgctgc tattaaacat atttgtaaat ggttt                   1845


<210>  6050
<211>  279
<212>  PRT
<213>  Homosapiens

<400>  6050

Met Ser Pro Ala Arg Arg Cys Arg Gly Met Arg Ala Ala Val Ala Ala 
1               5                   10                  15      


Ser Val Gly Leu Ser Glu Gly Pro Ala Gly Ser Arg Ser Gly Arg Leu 
            20                  25                  30          


Phe Arg Pro Pro Ser Pro Ala Pro Ala Ala Pro Gly Ala Arg Leu Leu 
        35                  40                  45              


Arg Leu Pro Gly Ser Gly Ala Val Gln Ala Ala Ser Pro Glu Arg Ala 
    50                  55                  60                  


Gly Trp Thr Glu Ala Leu Arg Ala Ala Val Ala Glu Leu Arg Ala Gly 
65                  70                  75                  80  


Ala Val Val Ala Val Pro Thr Asp Thr Leu Tyr Gly Leu Ala Cys Ala 
                85                  90                  95      


Ala Ser Cys Ser Ala Ala Leu Arg Ala Val Tyr Arg Leu Lys Gly Arg 
            100                 105                 110         


Ser Glu Ala Lys Pro Leu Ala Val Cys Leu Gly Arg Val Ala Asp Val 
        115                 120                 125             


Tyr Arg Tyr Cys Arg Val Arg Val Pro Glu Gly Leu Leu Lys Asp Leu 
    130                 135                 140                 


Leu Pro Gly Pro Val Thr Leu Val Met Glu Arg Ser Glu Glu Leu Asn 
145                 150                 155                 160 


Lys Asp Leu Asn Pro Phe Thr Pro Leu Val Gly Ile Arg Ile Pro Asp 
                165                 170                 175     


His Ala Phe Met Gln Asp Leu Ala Gln Met Phe Glu Gly Pro Leu Ala 
            180                 185                 190         


Leu Thr Ser Ala Asn Leu Ser Ser Gln Ala Ser Ser Leu Asn Val Glu 
        195                 200                 205             


Glu Phe Gln Asp Leu Trp Pro Gln Leu Ser Leu Val Ile Asp Gly Gly 
    210                 215                 220                 


Gln Ile Gly Asp Gly Gln Ser Pro Glu Cys Arg Leu Gly Ser Thr Val 
225                 230                 235                 240 


Val Asp Leu Ser Val Pro Gly Lys Phe Gly Ile Ile Arg Pro Gly Cys 
                245                 250                 255     


Ala Leu Glu Ser Thr Thr Ala Ile Leu Gln Gln Lys Tyr Gly Leu Leu 
            260                 265                 270         


Pro Ser His Ala Ser Tyr Leu 
        275                 


<210>  6051
<211>  1198
<212>  DNA
<213>  Homosapiens

<400>  6051
tcccggaagc gggcctgggc ggatgtctcc ggcgcgtcgg tgcaggggga tgagggccgc     60

ggtggctgcc agcgtggggt tgagcgaggg gcctgctggc tcccggagcg gtcgcctctt    120

ccgcccgccg agtcccgctc cggcggcccc cggcgcccgg ctgttgcggc tcccggggag    180

cggggccgtg caggccgcga gcccggagcg cgccggctgg accgaggcgc tgcgggccgc    240

cgtggccgag ctgcgcgccg gcgccgtggt ggccgtcccc accgatacgc tgtacggcct    300

ggcctgcgcg gcgagctgct cggcggctct gcgcgctgtg taccgcctca agggtcgcag    360

cgaggccaag cctctggccg tatgcctcgg ccgcgtggcc gacgtctaca gatactgccg    420

tgtgagagta cctgaggggc tcctgaaaga cctactgcca ggaccagtga ccctggtgat    480

ggaacgctcg gaggagctca acaaggacct aaaccctttt acgcctcttg taggcattcg    540

gattcctgat catgctttta tgcaagactt ggctcagatg tttgagggtc cgcttgctct    600

cactagtgcc aacctcagct cccaggccag ttctctgaat gtcgaggagt tccaggatct    660

ctggcctcag ttgtccttgg ttattgatgg gggacaaatt ggggatggcc agagccccga    720

gtgtcgcctt ggctcaactg tggttgattt gtctgtgccc ggaaagtttg gcatcattcg    780

tccaggctgt gccctggaaa gtactacagc catcctccaa cagaagtacg gactgctccc    840

ctcacatgcg tcctacctgt gaaactctgg gaagcaggaa ggcccaagac ctggtgctgg    900

atactatgtg tctgtccact gacgactgtc aaggcctcat ttgcagaggc caccggagct    960

agggcactag cctgactttt aaggcagtgt gtctttctga gcactgtaga ccaagccctt   1020

ggagctgctg gtttagcctt gcacctgggg aaaggatgta tttatttgta ttttcatata   1080

tcagccaaaa gctgaatgga aaagttaaga acattcctag gtggccttat tctaataagt   1140

ttcttctgtc tgttttgttt ttcaattgaa aagtaattaa ataacagatt tagaatct     1198


<210>  6052
<211>  279
<212>  PRT
<213>  Homosapiens

<400>  6052

Met Ser Pro Ala Arg Arg Cys Arg Gly Met Arg Ala Ala Val Ala Ala 
1               5                   10                  15      


Ser Val Gly Leu Ser Glu Gly Pro Ala Gly Ser Arg Ser Gly Arg Leu 
            20                  25                  30          


Phe Arg Pro Pro Ser Pro Ala Pro Ala Ala Pro Gly Ala Arg Leu Leu 
        35                  40                  45              


Arg Leu Pro Gly Ser Gly Ala Val Gln Ala Ala Ser Pro Glu Arg Ala 
    50                  55                  60                  


Gly Trp Thr Glu Ala Leu Arg Ala Ala Val Ala Glu Leu Arg Ala Gly 
65                  70                  75                  80  


Ala Val Val Ala Val Pro Thr Asp Thr Leu Tyr Gly Leu Ala Cys Ala 
                85                  90                  95      


Ala Ser Cys Ser Ala Ala Leu Arg Ala Val Tyr Arg Leu Lys Gly Arg 
            100                 105                 110         


Ser Glu Ala Lys Pro Leu Ala Val Cys Leu Gly Arg Val Ala Asp Val 
        115                 120                 125             


Tyr Arg Tyr Cys Arg Val Arg Val Pro Glu Gly Leu Leu Lys Asp Leu 
    130                 135                 140                 


Leu Pro Gly Pro Val Thr Leu Val Met Glu Arg Ser Glu Glu Leu Asn 
145                 150                 155                 160 


Lys Asp Leu Asn Pro Phe Thr Pro Leu Val Gly Ile Arg Ile Pro Asp 
                165                 170                 175     


His Ala Phe Met Gln Asp Leu Ala Gln Met Phe Glu Gly Pro Leu Ala 
            180                 185                 190         


Leu Thr Ser Ala Asn Leu Ser Ser Gln Ala Ser Ser Leu Asn Val Glu 
        195                 200                 205             


Glu Phe Gln Asp Leu Trp Pro Gln Leu Ser Leu Val Ile Asp Gly Gly 
    210                 215                 220                 


Gln Ile Gly Asp Gly Gln Ser Pro Glu Cys Arg Leu Gly Ser Thr Val 
225                 230                 235                 240 


Val Asp Leu Ser Val Pro Gly Lys Phe Gly Ile Ile Arg Pro Gly Cys 
                245                 250                 255     


Ala Leu Glu Ser Thr Thr Ala Ile Leu Gln Gln Lys Tyr Gly Leu Leu 
            260                 265                 270         


Pro Ser His Ala Ser Tyr Leu 
        275                 


<210>  6053
<211>  1133
<212>  DNA
<213>  Homosapiens

<400>  6053
tcccggaagc gggcctgggc ggatgtctcc ggcgcgtcgg tgcaggggga tgagggccgc     60

ggtggctgcc agcgtggggt tgagcgaggg gcctgctggc tcccggagcg gtcgcctctt    120

ccgcccgccg agtcccgctc cggcggcccc cggcgcccgg ctgttgcggc tcccggggag    180

cggggccgtg caggccgcga gcccggagcg cgccggctgg accgaggcgc tgcgggccgc    240

cgtggccgag ctgcgcgccg gcgccgtggt ggccgtcccc accgatacgc tgtacggcct    300

ggcctgcgcg gcgagctgct cggcggctct gcgcgctgtg taccgcctca agggtcgcag    360

cgaggccaag cctctggccg tatgcctcgg ccgcgtggcc gacgtctaca gatactgccg    420

tgtgagagta cctgaggggc tcctgaaaga cctactgcca ggaccagtga ccctggtgat    480

ggaacgctcg gaggagctca acaaggacct aaaccctttt acgcctcttg taggcattcg    540

gattcctgat catgctttta tgcaagactt ggctcagatg tttgagggtc cgcttgctct    600

cactagtgcc aacctcagct cccaggccag ttctctgaat gtcgaggagt tccaggatct    660

ctggcctcag ttgtccttgg ttattgatgg gggacaaatt ggggatggcc agagccccga    720

gtgtcgcctt ggctcaactg tggttgattt gtctgtgccc ggaaagtttg gcatcattcg    780

tccaggctgt gccctggaaa gtactacagc catcctccaa cagaagtacg gactgctccc    840

ctcacatgcg tcctacctgt gaaactctgg gaagcaggaa ggcccaagac ctggtgctgg    900

atactatgtg tctgtccact gacgactgtc aaggcctcat ttgcagaggc caccggagct    960

agggcactag cctgactttt aaggcagtgt gtctttctga gcactgtaga ccaagccctt   1020

ggagctgctg gtttagcctt gcacctgggg aaaggatgta tttatttgta ttttcatata   1080

tcagccaaaa gctgaatgga aaagttaaga acattcctag gtggccttat tct          1133


<210>  6054
<211>  279
<212>  PRT
<213>  Homosapiens

<400>  6054

Met Ser Pro Ala Arg Arg Cys Arg Gly Met Arg Ala Ala Val Ala Ala 
1               5                   10                  15      


Ser Val Gly Leu Ser Glu Gly Pro Ala Gly Ser Arg Ser Gly Arg Leu 
            20                  25                  30          


Phe Arg Pro Pro Ser Pro Ala Pro Ala Ala Pro Gly Ala Arg Leu Leu 
        35                  40                  45              


Arg Leu Pro Gly Ser Gly Ala Val Gln Ala Ala Ser Pro Glu Arg Ala 
    50                  55                  60                  


Gly Trp Thr Glu Ala Leu Arg Ala Ala Val Ala Glu Leu Arg Ala Gly 
65                  70                  75                  80  


Ala Val Val Ala Val Pro Thr Asp Thr Leu Tyr Gly Leu Ala Cys Ala 
                85                  90                  95      


Ala Ser Cys Ser Ala Ala Leu Arg Ala Val Tyr Arg Leu Lys Gly Arg 
            100                 105                 110         


Ser Glu Ala Lys Pro Leu Ala Val Cys Leu Gly Arg Val Ala Asp Val 
        115                 120                 125             


Tyr Arg Tyr Cys Arg Val Arg Val Pro Glu Gly Leu Leu Lys Asp Leu 
    130                 135                 140                 


Leu Pro Gly Pro Val Thr Leu Val Met Glu Arg Ser Glu Glu Leu Asn 
145                 150                 155                 160 


Lys Asp Leu Asn Pro Phe Thr Pro Leu Val Gly Ile Arg Ile Pro Asp 
                165                 170                 175     


His Ala Phe Met Gln Asp Leu Ala Gln Met Phe Glu Gly Pro Leu Ala 
            180                 185                 190         


Leu Thr Ser Ala Asn Leu Ser Ser Gln Ala Ser Ser Leu Asn Val Glu 
        195                 200                 205             


Glu Phe Gln Asp Leu Trp Pro Gln Leu Ser Leu Val Ile Asp Gly Gly 
    210                 215                 220                 


Gln Ile Gly Asp Gly Gln Ser Pro Glu Cys Arg Leu Gly Ser Thr Val 
225                 230                 235                 240 


Val Asp Leu Ser Val Pro Gly Lys Phe Gly Ile Ile Arg Pro Gly Cys 
                245                 250                 255     


Ala Leu Glu Ser Thr Thr Ala Ile Leu Gln Gln Lys Tyr Gly Leu Leu 
            260                 265                 270         


Pro Ser His Ala Ser Tyr Leu 
        275                 


<210>  6055
<211>  2553
<212>  DNA
<213>  Homosapiens

<400>  6055
tttgagataa aatctttcaa atttttttaa tttatattgc cccccaccac ctccctgcca     60

gctgggcaac cttcccactg ttggcccaag aactctcatg cctggccatc ccagtgtact    120

atcaatgcca ctgattcaca gaaaacagta tgtgcgctgg tgacatttcc aggggaagga    180

ctgggtaaac tcacctcgac attcagagaa ctggcctggg agctgaggtt ggcactagtg    240

agagcaagcg gaccctcaaa catctgagcc aagtcttgca taaaagcatg atcaggaatc    300

cgaatgccta caagctgtaa ggcaagggga aagggatcat gagaaaggtt ggaagggata    360

agagggtaag tcttatctgg atcctagtga aagccaagtg gcctggagtc tggggacaca    420

agagaaaact tgactcacag gcgtaaaagg gtttaggtcc ttgttgagct cctccgagcg    480

ttccatcacc agggtcactg gtcctggcag taggtctttc aggagcccct caggtactct    540

cacacggcag tatctgggaa acacagaaga ataaatccat tcaaaattga agggccactg    600

gtggtccttt cctagactct aggcagacgt agaaaaggaa tccttcgagt ttacaatggg    660

agccgcctgt ctccctgctt cacctcccta agagcttgag cagaaagcag ggctccagag    720

gcgcacccct ggcttgacgc ccatgtgcct ctggtctcag ggactacaac agctgcaccg    780

ctgtgatatc atgatagtgg gatcaagctc cacgttttat tttcttcaag gcattcgcta    840

ttaaattaag ctactgtgtt tgtttgcttt tttcccgggg gcctccccaa ttagcacaaa    900

tacgccaagg gaacagggtc cctgcctttc tcgtgtgttg ctgcttccca gcagcatgta    960

gttcagggcc cggggcacgt taagtcctcg gtacatattt ccagttccgg attccttggt   1020

gagcctggac aagcccctcc cgctctctgc gcctcagtct cccaagcctg tcaccggaaa   1080

cccctcccgc ggtgccgccc ctagcggggc cgggtcgggg cggccttacc tgtagacgtc   1140

ggccacgcgg ccgaggcata cggccagagg cttggcctcg ctgcgaccct tgaggcggta   1200

cacagcgcgc agagccgccg agcagctcgc cgcgcaggcc aggccgtaca gcgtatcggt   1260

ggggacggcc accacggcgc cggcgcgcag ctcggccacg gcggcccgca gcgcctcggt   1320

ccagccggcg cgctccgggc tcgcggcctg cacggccccg ctccccggga gccgcaacag   1380

ccgggcgccg ggggccgccg gagcgggact cggcgggcgg aagaggcgac cgctccggga   1440

gccagcaggc ccctcgctca accccacgct ggcagccacc gcggccctca tccccctgca   1500

ccgacgcgcc ggagacatcc gcccaggccc gcttccggga ggaagtgacg ctcccagcca   1560

gcttccggtc caggagactc ggccccgcct ctgcgccggg cagcttaaag ggaccacgac   1620

ccccaggagg attgaaggag accggtgggg acggggcggg gcgcagcctt gcgaagccct   1680

aacgcagcgc tggggagggg ggcggccgaa aggggggcgg tggtcgggcc gcgcaagcgg   1740

agatggaatg gggcccgggc tcagactggt cacgggggtg agagggggcc cgtcggggcg   1800

ggaggaaggg gcttggcccc gcgcaagcgc cggccctgac cgtctgtctc tcgctctctc   1860

ccgggcaggg aggctgccgg cgtggaccgc gggaaggcgg ggctggggct cggcgggagg   1920

ccacccccac agccgccccg ggaggagcgc gcccagcagc tgctggacgc ggtggagcag   1980

cggcagcggc agctcctgga caccatcgca gcctgcgagg agatgttacg gcagctgggc   2040

cgccggcgcc cggagccggc tggtggcggg aacgtctcag ccaaacctgg agcgcccccc   2100

cagccggctg tctccgccag aggcggcttt ccaaaggatg ctggcgatgg agctgcggag   2160

ccctgaccat ccccgagcag aataccctga cttctctccc tccccagggc cggtggctgg   2220

actctgaaca actcccttca gtaaaggggc cagtcttcac tggcagtggc tggtacttgg   2280

ctctcagcct ggagtggcag ctctgctagc agctgggttc actcccactt catcctggct   2340

gaaagcagtg ctgtgctttg aaatgcagcc aatgaatacc cagtctgatt acccagattt   2400

gggcagacca gcagtgctcg ccagagtggt ctggcctgct atgggggatc caggtggtgt   2460

tacatgtcca tttcatgttt tgggggcttt tagccccaca aaacaccttc agtagagcct   2520

tgattaaaag gaaacctgca gactctcctg gtg                                2553


<210>  6056
<211>  159
<212>  PRT
<213>  Homosapiens

<400>  6056

Met Gly Pro Gly Leu Arg Leu Val Thr Gly Val Arg Gly Gly Pro Ser 
1               5                   10                  15      


Gly Arg Glu Glu Gly Ala Trp Pro Arg Ala Ser Ala Gly Pro Asp Arg 
            20                  25                  30          


Leu Ser Leu Ala Leu Ser Arg Ala Gly Arg Leu Pro Ala Trp Thr Ala 
        35                  40                  45              


Gly Arg Arg Gly Trp Gly Ser Ala Gly Gly His Pro His Ser Arg Pro 
    50                  55                  60                  


Gly Arg Ser Ala Pro Ser Ser Cys Trp Thr Arg Trp Ser Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Ser Trp Thr Pro Ser Gln Pro Ala Arg Arg Cys Tyr Gly Ser 
                85                  90                  95      


Trp Ala Ala Gly Ala Arg Ser Arg Leu Val Ala Gly Thr Ser Gln Pro 
            100                 105                 110         


Asn Leu Glu Arg Pro Pro Ser Arg Leu Ser Pro Pro Glu Ala Ala Phe 
        115                 120                 125             


Gln Arg Met Leu Ala Met Glu Leu Arg Ser Pro Asp His Pro Arg Ala 
    130                 135                 140                 


Glu Tyr Pro Asp Phe Ser Pro Ser Pro Gly Pro Val Ala Gly Leu 
145                 150                 155                 


<210>  6057
<211>  1237
<212>  DNA
<213>  Homosapiens

<400>  6057
tgccgcccct agcggggccg ggtcggggcg gccttacctg tagacgtcgg ccacgcggcc     60

gaggcatacg gccagaggct tggcctcgct gcgacccttg aggcggtaca cagcgcgcag    120

agccgccgag cagctcgccg cgcaggccag gccgtacagc gtatcggtgg ggacggccac    180

cacggcgccg gcgcgcagct cggccacggc ggcccgcagc gcctcggtcc agccggcgcg    240

ctccgggctc gcggcctgca cggccccgct ccccgggagc cgcaacagcc gggcgccggg    300

ggccgccgga gcgggactcg gcgggcggaa gaggcgaccg ctccgggagc cagcaggccc    360

ctcgctcaac cccacgctgg cagccaccgc ggccctcatc cccctgcacc gacgcgccgg    420

agacatccgc ccaggcccgc ttccgggagg aagtgacgct cccagccagc ttccggtcca    480

ggagactcgg ccccgcctct gcgccgggca gcttaaaggg accacgaccc ccaggaggat    540

tgaaggagac cgggaggctg ccggcgtgga ccgcgggaag gcggggctgg ggctcggcgg    600

gaggccaccc ccacagccgc cccgggagga gcgcgcccag cagctgctgg acgcggtgga    660

gcagcggcag cggcagctcc tggacaccat cgcagcctgc gaggagatgt tacggcagct    720

gggccgccgg cgcccggagc cggctggtgg cgggaacgtc tcagccaaac ctggagcgcc    780

cccccagccg gctgtctccg ccagaggcgg ctttccaaag gatgctggcg atggagctgc    840

ggagccctga ccatccccga gcagaatacc ctgacttctc tccctcccca gggccggtgg    900

ctggactctg aacaactccc ttcagtaaag gggccagtct tcactggcag tggctggtac    960

ttggctctca gcctggagtg gcagctctgc tagcagctgg gttcactccc acttcatcct   1020

ggctgaaagc agtgctgtgc tttgaaatgc agccaatgaa tacccagtct gattacccag   1080

atttgggcag accagcagtg ctcgccagag tggtctggcc tgctatgggg gatccaggtg   1140

gtgttacatg tccatttcat gttttggggg cttttagccc cacaaaacac cttcagtaga   1200

gccttgatta aaaggaaacc tgcagactct cctggtg                            1237


<210>  6058
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  6058

Met Leu Arg Gln Leu Gly Arg Arg Arg Pro Glu Pro Ala Gly Gly Gly 
1               5                   10                  15      


Asn Val Ser Ala Lys Pro Gly Ala Pro Pro Gln Pro Ala Val Ser Ala 
            20                  25                  30          


Arg Gly Gly Phe Pro Lys Asp Ala Gly Asp Gly Ala Ala Glu Pro 
        35                  40                  45          


<210>  6059
<211>  1358
<212>  DNA
<213>  Homosapiens

<400>  6059
ggggccgggt cggggcggcc ttacctgtag acgtcggcca cgcggccgag gcatacggcc     60

agaggcttgg cctcgctgcg acccttgagg cggtacacag cgcgcagagc cgccgagcag    120

ctcgccgcgc aggccaggcc gtacagcgta tcggtgggga cggccaccac ggcgccggcg    180

cgcagctcgg ccacggcggc ccgcagcgcc tcggtccagc cggcgcgctc cgggctcgcg    240

gcctgcacgg ccccgctccc cgggagccgc aacagccggg cgccgggggc cgccggagcg    300

ggactcggcg ggcggaagag gcgaccgctc cgggagccag caggcccctc gctcaacccc    360

acgctggcag ccaccgcggc cctcatcccc ctgcaccgac gcgccggaga catccgccca    420

ggcccgcttc cgggaggaag tgacgctccc agccagcttc cggtccagga gactcggccc    480

cgcctctgcg ccgggcagct taaagggacc acgaccccca ggaggattga aggagaccgg    540

tggggacggg gcggggcgca gccttgcgaa gccctaacgc agcgctgggg aggggggcgg    600

ccgaaagggg ggcggtggtc gggccgcgca agcggagatg gaatggggcc cgggctcaga    660

ctggtcacgg ggggaggctg ccggcgtgga ccgcgggaag gcggggctgg ggctcggcgg    720

gaggccaccc ccacagccgc cccgggagga gcgcgcccag cagctgctgg acgcggtgga    780

gcagcggcag cggcagctcc tggacaccat cgcagcctgc gaggagatgt tacggcagct    840

gggccgccgg cgcccggagc cggctggtgg cgggaacgtc tcagccaaac ctggagcgcc    900

cccccagccg gctgtctccg ccagaggcgg ctttccaaag gatgctggcg atggagctgc    960

ggagccctga ccatccccga gcagaatacc ctgacttctc tccctcccca gggccggtgg   1020

ctggactctg aacaactccc ttcagtaaag gggccagtct tcactggcag tggctggtac   1080

ttggctctca gcctggagtg gcagctctgc tagcagctgg gttcactccc acttcatcct   1140

ggctgaaagc agtgctgtgc tttgaaatgc agccaatgaa tacccagtct gattacccag   1200

atttgggcag accagcagtg ctcgccagag tggtctggcc tgctatgggg gatccaggtg   1260

gtgttacatg tccatttcat gttttggggg cttttagccc cacaaaacac cttcagtaga   1320

gccttgatta aaaggaaacc tgcagactct cctggtga                           1358


<210>  6060
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  6060

Met Gly Pro Gly Leu Arg Leu Val Thr Gly Gly Gly Cys Arg Arg Gly 
1               5                   10                  15      


Pro Arg Glu Gly Gly Ala Gly Ala Arg Arg Glu Ala Thr Pro Thr Ala 
            20                  25                  30          


Ala Pro Gly Gly Ala Arg Pro Ala Ala Ala Gly Arg Gly Gly Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Pro Gly His His Arg Ser Leu Arg Gly Asp Val Thr 
    50                  55                  60                  


Ala Ala Gly Pro Pro Ala Pro Gly Ala Gly Trp Trp Arg Glu Arg Leu 
65                  70                  75                  80  


Ser Gln Thr Trp Ser Ala Pro Pro Ala Gly Cys Leu Arg Gln Arg Arg 
                85                  90                  95      


Leu Ser Lys Gly Cys Trp Arg Trp Ser Cys Gly Ala Leu Thr Ile Pro 
            100                 105                 110         


Glu Gln Asn Thr Leu Thr Ser Leu Pro Pro Gln Gly Arg Trp Leu Asp 
        115                 120                 125             


Ser Glu Gln Leu Pro Ser Val Lys Gly Pro Val Phe Thr Gly Ser Gly 
    130                 135                 140                 


Trp Tyr Leu Ala Leu Ser Leu Glu Trp Gln Leu Cys 
145                 150                 155     


<210>  6061
<211>  756
<212>  DNA
<213>  Homosapiens

<400>  6061
gaatggggcc cgggctcaga ctggtcacgg gggtgagagg gggcccgtcg gggcgggagg     60

aaggggcttg gccccgcgca agcgccggcc ctgaccgtct gtctctcgct ctctcccggg    120

cagggaggct gccggcgtgg accgcgggaa ggcggggctg gggctcggcg ggaggccacc    180

cccacagccg ccccgggagg agcgcgccca gcagctgctg gacgcggtgg agcagcggca    240

gcggcagctc ctggacacca tcgcagcctg cgaggagatg ttacggcagc tgggccgccg    300

gcgcccccgg ctgtctccgc cagaggcggc tttccaaagg atgctggcga tggagctgcg    360

gagccctgac catccccgag cagaataccc tgacttctct ccctccccag ggccggtggc    420

tggactctga acaactccct tcagtaaagg ggccagtctt cactggcagt ggctggtact    480

tggctctcag cctggagtgg cagctctgct agcagctggg ttcactccca cttcatcctg    540

gctgaaagca gtgctgtgct ttgaaatgca gccaatgaat acccagtctg attacccaga    600

tttgggcaga ccagcagtgc tcgccagagt ggtctggcct gctatggggg atccaggtgg    660

tgttacatgt ccatttcatg ttttgggggc ttttagcccc acaaaacacc ttcagtagag    720

ccttgattaa aaggaaacct gcagactctc ctggtg                              756


<210>  6062
<211>  169
<212>  PRT
<213>  Homosapiens

<400>  6062

Met Gly Pro Gly Leu Arg Leu Val Thr Gly Val Arg Gly Gly Pro Ser 
1               5                   10                  15      


Gly Arg Glu Glu Gly Ala Trp Pro Arg Ala Ser Ala Gly Pro Asp Arg 
            20                  25                  30          


Leu Ser Leu Ala Leu Ser Arg Ala Gly Arg Leu Pro Ala Trp Thr Ala 
        35                  40                  45              


Gly Arg Arg Gly Trp Gly Ser Ala Gly Gly His Pro His Ser Arg Pro 
    50                  55                  60                  


Gly Arg Ser Ala Pro Ser Ser Cys Trp Thr Arg Trp Ser Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Ser Trp Thr Pro Ser Gln Pro Ala Arg Arg Cys Tyr Gly Ser 
                85                  90                  95      


Trp Ala Ala Gly Ala Pro Gly Cys Leu Arg Gln Arg Arg Leu Ser Lys 
            100                 105                 110         


Gly Cys Trp Arg Trp Ser Cys Gly Ala Leu Thr Ile Pro Glu Gln Asn 
        115                 120                 125             


Thr Leu Thr Ser Leu Pro Pro Gln Gly Arg Trp Leu Asp Ser Glu Gln 
    130                 135                 140                 


Leu Pro Ser Val Lys Gly Pro Val Phe Thr Gly Ser Gly Trp Tyr Leu 
145                 150                 155                 160 


Ala Leu Ser Leu Glu Trp Gln Leu Cys 
                165                 


<210>  6063
<211>  7972
<212>  DNA
<213>  Homosapiens

<400>  6063
ggaagtgacg ttaggggaag gtgggggcaa tcatggtgcc gctggggagg ggagaagctg     60

ctgctgccgc cgttgccggg agccgcggag acaagtcatt acgttttcat ttctcacaac    120

tgggctgagc acaactgaac catgggggaa cacagtccag acaacaacat catctacttt    180

gaggcagagg aagatgagct gacccccgat gataaaatgc tcaggtttgt ggataaaaac    240

ggactggtgc cttcctcatc tggaactgtt tatgatagga ccactgttct tattgagcag    300

gaccctggca ctttggagga tgaagatgac gacggacagt gcggagaaca cttgcctttt    360

ctagtagggg gtgaagaggg ctttcacctg atagatcatg aagcaatgtc ccagggttat    420

gtgcagcaca ttatctcacc agatcagatt catttgacaa taaaccctgg ttccacaccc    480

atgccaagaa atattgaagg tgcaaccctc actctgcagt cggaatgtcc ggaaacaaaa    540

cgtaaagaag taaagcggta ccaatgtacc tttgagggct gtccccgcac ctacagcaca    600

gcaggcaacc tgcgaaccca ccagaagact caccgaggag agtacacctt tgtctgtaat    660

caggagggct gtggcaaagc cttccttacc tcttacagcc tcaggatcca cgtgcgagtg    720

cacacgaagg agaagccatt tgagtgtgac gtgcagggct gtgagaaggc attcaacaca    780

ctgtacaggc tgaaagcaca tcagaggctt cacacaggga aaacgtttaa ctgtgaatct    840

gaaggctgca gcaaatactt caccacactc agtgatctga ggaagcacat tcgaactcat    900

acaggggaaa agccatttcg gtgcgatcac gatggctgtg gaaaagcatt tgcagcaagc    960

caccacctta aaactcacgt tcgtacacat actggtgaaa gacccttctt ctgccccagt   1020

aatggctgtg agaaaacatt cagcactcaa tacagtctca aaagtcacat gaaaggtcat   1080

gataacaaag gacactcata caatgcactt ccacaacaca atggatcaga ggatacaaat   1140

cactcacttt gtctaagtga cttgagcctt ctgtccacag attctgaatt gcgagaaaat   1200

tccagtacga cccagggcca ggacctcagc acaatttcac cagcaatcat ctttgaatca   1260

atgttccaga attcagatga tacggcaatt caggaagatc ctcaacagac agcttccttg   1320

actgaaagtt ttaatggtga tgcagagtca gtcagtgatg ttccgccatc cacaggaaat   1380

tcagcatctt tatctcttcc acttgtactg caacctggcc tctccgagcc accccagcct   1440

ctactacctg cctcagctcc gtctgctcct ccgcctgctc cctccctagg acctggctcc   1500

cagcaagctg catttggcaa cccccctgct ctcttacaac ctccagaagt gcctgttccc   1560

cacagcacac agtttgctgc taatcatcaa gagtttcttc cgcaccccca ggcaccgcag   1620

cccattgtac caggactttc tgttgttgct ggggcttctg catcagcagc ggcagtggca   1680

tcagctgtgg cagcaccagc cccaccacaa agtactactg agcccctgcc agccatggtc   1740

cagactctgc ccctgggtgc caactctgtc ctaactaata atcccacaat aaccatcacc   1800

ccaactccca acacagctat cctgcagtcc agcctagtca tgggagaaca gaacttacaa   1860

tggatattaa atggtgccac cagttctcca caaaaccaag aacaaattca gcaagcatct   1920

aaagttgaga aggtgttttt taccactgca gtaccagtag ccagtagccc agggagctct   1980

gtccagcaga ttggcctcag tgttcctgtg atcatcatca aacaagaaga ggcatgtcag   2040

tgtcagtgtg catgccggga ctctgcaaag gagcgggcat ccagcaggag aaagggctgc   2100

tcctccccac cccctccaga gccgagcccc caggctcctg atgggcccag cctgcagctc   2160

ccagcgcaga ctttctcttc agcccctgtt cccgggtcat catcctctac cttgccctcc   2220

tcctgtgagc aaagccgaca agcagagact ccttcagacc ctcagacaga aacattaagt   2280

gccatggatg tgtcagagtt tctatccctc cagagcctgg acaccccgtc caatctgatt   2340

cccattgaag cactactgca gggggaggag gagatgggcc tcaccagcag cttctccaag   2400

tgaagggccc atgtgtgctc acctctggga aaagcgggtg agcaggaggc atgaggtaca   2460

atgcctgcca tcatgggtca gaaatttgaa ggatgaagaa atctactgtt tgaaatcctc   2520

acctttcaga cgtattttct ttattcacat cccaggagca tccattttaa ggaactattc   2580

tttggaaaaa aacaaaaaac aaaaaaaaca acaaaaaaag ctaagttata agtgaactgt   2640

ttggctgcac tgtatgtcac ttttgcttgt tgtcatgtga acttggaaac taaggttact   2700

cgtgtgcata aaaattctaa atgaaagggt gtggtttcca tcaatctgat gctgcccatc   2760

gcttgcactg gggtctttgt ggatcgggca ggagttttca gtgtgttggg tgttgctcct   2820

tcctatgtgt cttttgaatc tgaggctgac atttgcttgg aaggccagac ccttgctcca   2880

tcagagaggg cagtggcaaa ggccagtgag gcagctgtga gttggacagg gttcaggtga   2940

gatggtgttg tcatttgtgc ttagtgttgg tggtgctcag ggtggataac acgggtcgtt   3000

ctgcagcccg cttcagcaca aataggcagc ttaaggcctg gctcacaggc tgtggggttg   3060

atctggctct gcagaggccc taggcagctt gttgactgct gtctgttgat gacgtgtgtg   3120

caaagcaggc tctagcaaca tgatcactgt ccttgccttc ctggttcttt ctctcggttg   3180

gttgccaggg cttgcagatc gcagtgaatt ttccttgggg aacatcgctg ttttgtccta   3240

gagtgaactt gtggcttatg gccagtgctg tttggtggtc tgccttcttt ttaatggtat   3300

tttcttcctc agagcagaag ggctgcattt tgcttatcag aagaaggtgc agatttaagg   3360

gaattcatat gaggtggcat gtaattggca ggccaggtgt cctggttcca ggttccagcc   3420

aggctttggg ttgccccctc catctctgcc cccctctgga ttttgcatac agcctcatac   3480

agtgcaaaca aggatgtgac ttgctcagct tagtcatgtg atttatttaa aaaaaaaaaa   3540

aaaagaaaca caaaacgatg atcttctact cagggtatag caaaacaaaa aaattccctt   3600

tccaccaaaa agcctgaaat gttgcaataa gttatctcat ttggaatgtt tcattaagtt   3660

gtgttatagg aaaaaattgt gtgtgtgtgt tatagaatta tatccatatg tctgcctttg   3720

gctccaagtc attgcctctt aaaataaaag atacaatcca tactagcatg aaaagtttcc   3780

ctcaacaggc tatattaaca tagtcatgag tgctgaccaa actcaccgag ctcagaggcc   3840

aggcatggcc tgaggtgcag aataggcctc tgcctcccaa gagccctttc cttgccctga   3900

gcaaggagtg gtgttccaca aacaaggctg ctcttctaag ccaacagtgt caggcaggaa   3960

gcagccataa ttttgccttg cattttcatt ccctaatgta aagggatctg cattggtcac   4020

tctcctgttc tctgagccat tgctcagggc cagccaagat attattgaga acagataatt   4080

taccttggag ccagaggccc tccctgcctt tagcaaggat gttcagggac agacaaagag   4140

ggcagtggtg gtgaatgttg ttactgccat gaggagaaat ggcagtaaga aatcttaact   4200

acaagcagcc aatttctcat tccaggaccc tagccagaat aattgacttc tttttttttt   4260

tgagacagag ttttgctttt gttgccctgg ctggagtgca gtggcgcaat cttggctcac   4320

cgcaacctcc acttcccagg ttcaagcaat tctgcctcag cctcccgagt agctgggatt   4380

acaggcatgc gccaccacgc ctggctaatt ttgtattttt agtagagacg gggtttctcc   4440

atgttggtca ggctggtctc gaactcccaa cgtcaggtga tcctcccgcc tcagtctccc   4500

aaagtgctgg gattacaggt gtgagccacc atgcctggtc tagggaattg acttcttttt   4560

gaccttctgc actcccttcc ccaaaaggat tgtggcttct gttgaccatt gacctcagca   4620

gaagttgata aggcaggagg tttccagtcc tcctggaaaa ccaactgctg agcatgagtt   4680

gtccttggct gtctctgggc ctcgcaccca tgggaagttt tgaggtaggg cccttgctgt   4740

ttacaacttc tgagagagta gtgatgggac cccaaagtaa gcttgtatca gagggcagta   4800

atgaccttcc catatcccca tcctgtggtc acctgggatt tgggttccct ggggcggaag   4860

tgggaaatag gagcccaggg aaggacatct gaagcaccca cagtttaaat agcgactctt   4920

cttggttagc cagggctgtg ctcatgttgg gccctaccca ggtcagtggc cttttcactc   4980

tcaaagatcg ggggtgacga agcagcatct taaacagtgt ttaggctgac agatttttcc   5040

agttgaagaa gctgaagtat ctgccttttg agggtgactc tagattacaa gagagactat   5100

cagatccaat cagcttttga aaaatcagga atgtgcttaa aatgccagtg agtggttgtg   5160

aagatcaggt ttatttccca ggataggcag tctttctttc cctccttttc cagttctctt   5220

ttcctacctg tccttccata agcctggtct ctagtgccga ggaccttgga gaagagaggg   5280

cccctagcta agctggagcc agaaagaacc ttcatggtga gtgtggtttc ccaaacttgg   5340

gaaatgaacc tagggtgagg ttagggagga tttgtagaat tctagcaggt aaaaatcaag   5400

cctttttccc ctcccatagt aaacttaacc attttcaccc tgtacgttat cttctagctc   5460

ctactaacat ctccaattag acaaccgctt caaagggtgc ttagcaccag ggattggggt   5520

tcatggactt aggaggtggt aaggaaactg gctggcacca ccaaactgcc ttagtgaact   5580

tggcccttcc caggcaggta ggttgggcat tgagggaagg tggcccagtc tttgctggca   5640

gggtctggcc agtctcatgg gggcaccacc agtttggtga cagaagtggt gtcatttatt   5700

gaattccacc tccgtttaga aggagatcat ggtacaaagc ccaggagggg ccttaagatg   5760

tgaagatctc tctgagtaaa aggcaagggg cttctcttct tcacctctgg gatagttggt   5820

agatcggaga gttttatttt cagggtcaag gctgtggact gatggggata ttggagggtg   5880

ggtgggtttt cctgagagac tttgtataat gctgaatgtg tccagaggga caagtttgca   5940

gaacctcata ttggtatatt aaagaaataa taaaataaaa aagcacttta ggttatttta   6000

tctttaaccc gattgctgca atttcttttg tgtgtatata tacatatata tactttccac   6060

aaagttttat tttttgctca gaataaaaag ttaaattgag gtgtgaaaag aaaagcactt   6120

accttggtgc aatatgtgta gcttgatggt cgttgtccca tgtggccctg gcctggcagc   6180

gtttttccgc tcaatcagcc ctgtgctgtg agactgtcca tagggaaaca ctattatgca   6240

ttctcagcaa ccgctcaatc tatgcaagcc ttccctgtgt gccccagggc gccccctcag   6300

gctctctgaa gaactgctgt gggtcctgtt ttctgctgac tgttgaggcc ctttttcatc   6360

acttcttggt ctctcgccat cttttccctc ttcaccatta caaaatgatg cctgaaagga   6420

aggaacagat tgttcctagg tagaaacctg gcaccttcta gacttttata tttgtaatca   6480

catccattgt ccttaaagac ttttccagag tgattgaaac cattgatttg tggaactgca   6540

acaatatttc tcaagagttt acaattgtct tacaccacca atcagaaata tgtttgggga   6600

ggcatgggtg gcagggggca acatgagcca tttccatact gctccccata ctacctgtgt   6660

tggttcctta agcaaaaagg cctccagcct tcattaaatc ctataaacaa acattacatc   6720

ccatgaatca ttatcaactt tcttccttta ctccacctcc cccattttat cttcaattct   6780

caggctatag aatagacaag ttttagaata tacttcagcc aaagcagaag gattttcata   6840

gatccaatat gcaaatagtt ctgctgtgac atagatcaga aattgtctgt tccttaatat   6900

ttgggggtgg aggcaacaaa actgaagcat atttctgatt ggttagccat tttggcctgt   6960

ttcctcttgc atgtttttta gggagagagg gaaacagtcc tgtatttctt ctgatgccct   7020

ttggggaagc cgacgaccac tgggcatttc tcactgttac tcctgttcaa gagagggctt   7080

ctcagtctgc actgaaaaat gcaaattaaa ctggatcttt atgtcaatgt gtacatagta   7140

caagcttttt tactggaatt gaggtttaaa accacacact gcccttttgg tggtgtgcct   7200

gttgggccaa aaattgggtg ataatgtagt gtcactttct cagctcaatg cagtttctac   7260

tttttcttat gggaaaattt ttcataaaac ctttttgcac caaaacccag gggtgttttt   7320

tgcaatatcc ttgttatcct cgtagtgtgc caagtcagag gctttctctt gcccttttcc   7380

tgctgtgttc tcaggcctcc caagggctat ttgactcaac agtctacatc cttcgttgtg   7440

ttttggagaa tgtgggggtg ggggtcagag ttcaaggtgt ctgttccctt ttcctgtgaa   7500

ctctttctag tccctatttg gggagggtgg ctggaaacag atttttgctg aatttctggc   7560

tcagatcttc tagccaggaa aggcaagagc ccccaagagc cctttttttt gacatacact   7620

aatcattggc cggggtcttg gtgacaactt ttaaaatccc aaatagtttt atttggatta   7680

tgtaaaagta agtgtgaaac atgggaacaa cggacttcca ctgagcgatg tgaaaacgtt   7740

acaggttcag tacttccaaa ggaagaaacc tccaaaccca aaaaagaata aatatgaatt   7800

tgtatttttg aagaatgtga aataatggtg tttgcttaat tgctcatttt gtataaactt   7860

aatattgtac tttaaaatat ctgctaaaaa gtgaaaattt aactttttgg aattgaaaaa   7920

gcaatattaa atactaatga aatcctaatt aaatgcttat ttaaatctgg ta           7972


<210>  6064
<211>  753
<212>  PRT
<213>  Homosapiens

<400>  6064

Met Gly Glu His Ser Pro Asp Asn Asn Ile Ile Tyr Phe Glu Ala Glu 
1               5                   10                  15      


Glu Asp Glu Leu Thr Pro Asp Asp Lys Met Leu Arg Phe Val Asp Lys 
            20                  25                  30          


Asn Gly Leu Val Pro Ser Ser Ser Gly Thr Val Tyr Asp Arg Thr Thr 
        35                  40                  45              


Val Leu Ile Glu Gln Asp Pro Gly Thr Leu Glu Asp Glu Asp Asp Asp 
    50                  55                  60                  


Gly Gln Cys Gly Glu His Leu Pro Phe Leu Val Gly Gly Glu Glu Gly 
65                  70                  75                  80  


Phe His Leu Ile Asp His Glu Ala Met Ser Gln Gly Tyr Val Gln His 
                85                  90                  95      


Ile Ile Ser Pro Asp Gln Ile His Leu Thr Ile Asn Pro Gly Ser Thr 
            100                 105                 110         


Pro Met Pro Arg Asn Ile Glu Gly Ala Thr Leu Thr Leu Gln Ser Glu 
        115                 120                 125             


Cys Pro Glu Thr Lys Arg Lys Glu Val Lys Arg Tyr Gln Cys Thr Phe 
    130                 135                 140                 


Glu Gly Cys Pro Arg Thr Tyr Ser Thr Ala Gly Asn Leu Arg Thr His 
145                 150                 155                 160 


Gln Lys Thr His Arg Gly Glu Tyr Thr Phe Val Cys Asn Gln Glu Gly 
                165                 170                 175     


Cys Gly Lys Ala Phe Leu Thr Ser Tyr Ser Leu Arg Ile His Val Arg 
            180                 185                 190         


Val His Thr Lys Glu Lys Pro Phe Glu Cys Asp Val Gln Gly Cys Glu 
        195                 200                 205             


Lys Ala Phe Asn Thr Leu Tyr Arg Leu Lys Ala His Gln Arg Leu His 
    210                 215                 220                 


Thr Gly Lys Thr Phe Asn Cys Glu Ser Glu Gly Cys Ser Lys Tyr Phe 
225                 230                 235                 240 


Thr Thr Leu Ser Asp Leu Arg Lys His Ile Arg Thr His Thr Gly Glu 
                245                 250                 255     


Lys Pro Phe Arg Cys Asp His Asp Gly Cys Gly Lys Ala Phe Ala Ala 
            260                 265                 270         


Ser His His Leu Lys Thr His Val Arg Thr His Thr Gly Glu Arg Pro 
        275                 280                 285             


Phe Phe Cys Pro Ser Asn Gly Cys Glu Lys Thr Phe Ser Thr Gln Tyr 
    290                 295                 300                 


Ser Leu Lys Ser His Met Lys Gly His Asp Asn Lys Gly His Ser Tyr 
305                 310                 315                 320 


Asn Ala Leu Pro Gln His Asn Gly Ser Glu Asp Thr Asn His Ser Leu 
                325                 330                 335     


Cys Leu Ser Asp Leu Ser Leu Leu Ser Thr Asp Ser Glu Leu Arg Glu 
            340                 345                 350         


Asn Ser Ser Thr Thr Gln Gly Gln Asp Leu Ser Thr Ile Ser Pro Ala 
        355                 360                 365             


Ile Ile Phe Glu Ser Met Phe Gln Asn Ser Asp Asp Thr Ala Ile Gln 
    370                 375                 380                 


Glu Asp Pro Gln Gln Thr Ala Ser Leu Thr Glu Ser Phe Asn Gly Asp 
385                 390                 395                 400 


Ala Glu Ser Val Ser Asp Val Pro Pro Ser Thr Gly Asn Ser Ala Ser 
                405                 410                 415     


Leu Ser Leu Pro Leu Val Leu Gln Pro Gly Leu Ser Glu Pro Pro Gln 
            420                 425                 430         


Pro Leu Leu Pro Ala Ser Ala Pro Ser Ala Pro Pro Pro Ala Pro Ser 
        435                 440                 445             


Leu Gly Pro Gly Ser Gln Gln Ala Ala Phe Gly Asn Pro Pro Ala Leu 
    450                 455                 460                 


Leu Gln Pro Pro Glu Val Pro Val Pro His Ser Thr Gln Phe Ala Ala 
465                 470                 475                 480 


Asn His Gln Glu Phe Leu Pro His Pro Gln Ala Pro Gln Pro Ile Val 
                485                 490                 495     


Pro Gly Leu Ser Val Val Ala Gly Ala Ser Ala Ser Ala Ala Ala Val 
            500                 505                 510         


Ala Ser Ala Val Ala Ala Pro Ala Pro Pro Gln Ser Thr Thr Glu Pro 
        515                 520                 525             


Leu Pro Ala Met Val Gln Thr Leu Pro Leu Gly Ala Asn Ser Val Leu 
    530                 535                 540                 


Thr Asn Asn Pro Thr Ile Thr Ile Thr Pro Thr Pro Asn Thr Ala Ile 
545                 550                 555                 560 


Leu Gln Ser Ser Leu Val Met Gly Glu Gln Asn Leu Gln Trp Ile Leu 
                565                 570                 575     


Asn Gly Ala Thr Ser Ser Pro Gln Asn Gln Glu Gln Ile Gln Gln Ala 
            580                 585                 590         


Ser Lys Val Glu Lys Val Phe Phe Thr Thr Ala Val Pro Val Ala Ser 
        595                 600                 605             


Ser Pro Gly Ser Ser Val Gln Gln Ile Gly Leu Ser Val Pro Val Ile 
    610                 615                 620                 


Ile Ile Lys Gln Glu Glu Ala Cys Gln Cys Gln Cys Ala Cys Arg Asp 
625                 630                 635                 640 


Ser Ala Lys Glu Arg Ala Ser Ser Arg Arg Lys Gly Cys Ser Ser Pro 
                645                 650                 655     


Pro Pro Pro Glu Pro Ser Pro Gln Ala Pro Asp Gly Pro Ser Leu Gln 
            660                 665                 670         


Leu Pro Ala Gln Thr Phe Ser Ser Ala Pro Val Pro Gly Ser Ser Ser 
        675                 680                 685             


Ser Thr Leu Pro Ser Ser Cys Glu Gln Ser Arg Gln Ala Glu Thr Pro 
    690                 695                 700                 


Ser Asp Pro Gln Thr Glu Thr Leu Ser Ala Met Asp Val Ser Glu Phe 
705                 710                 715                 720 


Leu Ser Leu Gln Ser Leu Asp Thr Pro Ser Asn Leu Ile Pro Ile Glu 
                725                 730                 735     


Ala Leu Leu Gln Gly Glu Glu Glu Met Gly Leu Thr Ser Ser Phe Ser 
            740                 745                 750         


Lys 
    


<210>  6065
<211>  1296
<212>  DNA
<213>  Homosapiens

<400>  6065
tgtcttacac caccaatcag aaatatgttt ggggaggcat gggtggcagg gggcaacatg     60

agccatttcc atactgctcc ccatactacc tgtgttggtt ccttaagcaa aaaggcctcc    120

agccttcatt aaatcctata aacaaacatt acatcccatg aatcattatc aactttcttc    180

ctttactcca cctcccccat tttatcttca attctcaggc tatagaatag acaagtttta    240

gaatatactt cagccaaagc agaaggattt tcatagatcc aatatgcaaa tagttctgct    300

gtgacataga tcagaaattg tctgttcctt aatatttggg ggtggaggca acaaaactga    360

agcatatttc tgattggtta gccattttgg cctgtttcct cttgcatgtt ttttagggag    420

agagggaaac agtcctgtat ttcttctgat gccctttggg gaagccgacg accactgggc    480

atttctcact gttactcctg ttcaagagag ggcttctcag tctgcactga aaaatgcaaa    540

ttaaactgga tctttatgtc aatgtgtaca tagtacaagc ttttttactg gaattgaggt    600

ttaaaaccac acactgccct tttggtggtg tgcctgttgg gccaaaaatt gggtgataat    660

gtagtgtcac tttctcagct caatgcagtt tctacttttt cttatgggaa aatttttcat    720

aaaacctttt tgcaccaaaa cccaggggtg ttttttgcaa tatccttgtt atcctcgtag    780

tgtgccaagt cagagttcaa ggtgtctgtt cccttttcct gtgaactctt tctagtccct    840

atttggggag ggtggctgga aacagatttt tgctgaattt ctggctcaga tcttctagcc    900

aggaaaggca agagccccca agagcccttt tttttgacat acactaatca ttggccgggg    960

tcttggtgac aacttttaaa atcccaaata gttttatttg gattatgtaa aagtaagtgt   1020

gaaacatggg aacaacggac ttccactgag cgatgtgaaa acgttacagg ttcagtactt   1080

ccaaaggaag aaacctccaa acccaaaaaa gaataaatat gaatttgtat ttttgaagaa   1140

tgtgaaataa tggtgtttgc ttaattgctc attttgtata aacttaatat tgtactttaa   1200

aatatctgct aaaaagtgaa aatttaactt tttggaattg aaaaagcaat attaaatact   1260

aatgaaatcc taattaaatg cttatttaaa tctggt                             1296


<210>  6066
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  6066

Met Gln Phe Leu Leu Phe Leu Met Gly Lys Phe Phe Ile Lys Pro Phe 
1               5                   10                  15      


Cys Thr Lys Thr Gln Gly Cys Phe Leu Gln Tyr Pro Cys Tyr Pro Arg 
            20                  25                  30          


Ser Val Pro Ser Gln Ser Ser Arg Cys Leu Phe Pro Phe Pro Val Asn 
        35                  40                  45              


Ser Phe 
    50  


<210>  6067
<211>  464
<212>  DNA
<213>  Homosapiens

<400>  6067
cactgttaaa aatacattta tcattaaaat atattacaca tggagacagg atgcatcata     60

tacagtttgg aagacttgct ggcccagaaa atcccacttg tttcaccgaa cactcatttt    120

ttcagtgatt ttacatttta tttttagaga cggggtctcc ctctctcacc cgggctggcg    180

tacagtgatg tggtcatagg tcactgcagc ctcaaactcc tgtgctcaag tgagccaccc    240

acgtcagcct cccaagtaac tgggaccaca ggcatgcatc accacaccca gctaattttt    300

taaaaatgtt tttgtagaga gggggtctcc ctgtgttgcc cagcctggtc ccaaactcct    360

ggtctcaagt gatgctccca cctcagtctc ccaaagcagg tggatcacct gaggccaggc    420

attcgagacc agcctggcca acatggtgaa accgtgtcta tact                     464


<210>  6068
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  6068

Met Glu Thr Gly Cys Ile Ile Tyr Ser Leu Glu Asp Leu Leu Ala Gln 
1               5                   10                  15      


Lys Ile Pro Leu Val Ser Pro Asn Thr His Phe Phe Ser Asp Phe Thr 
            20                  25                  30          


Phe Tyr Phe 
        35  


<210>  6069
<211>  858
<212>  DNA
<213>  Homosapiens

<400>  6069
caccagttcc tctgcaaccc actctgagcc tctctctcct cctattttac ttgaggctgc     60

caattaccag ccccacctgt ttcagctcaa gagatgcctt aagataatta tgtgaggcca    120

cttggtagca agaatggcag ctatttcctg agcctagtac cccaattaag cccaccattg    180

gttagcacac tcagcgctgt gagtcgtgaa gacacgggag aaaatccacc ataataaaac    240

tgacattcaa ttttcaactt tagttattta acacagattt ttttattttt tatttttttt    300

tattttgaga cggagttttg ctctgtcgcg cagggtggag tgcggtggca cgatctcggc    360

tcactgcaac ctctgcctcc tgggtgcaag caattatcct gcctcagcct cccgagtagc    420

tgggactgca ggcacacact gccacgccca gctaattttt tgcattttag tagagacggg    480

gtttcaccgt gttgcccagg ctgttctaaa actcctgaac tcaggtaatc tgcctgcctc    540

ggcctcccca agtgctagga ttacagatgt gagccaccac gcccggcctt tttttttttt    600

ttttcttttt tgagatggag tttcactctt gttgcccagg ctggagtgcg ttggctgacc    660

tatgaccaca tcactgtacg ccagcccggg tgagagaggg agaccccgtc tctaaaaata    720

aaatgtaaaa tcactgaaaa aatgagtgtt cggtgaaaca agtgggattt tctgggccag    780

caagtcttcc aaactgtata tgatgcatcc tgtctccatg tgtaatatat tttaatgata    840

aatgtatttt taacagtg                                                  858


<210>  6070
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  6070

Asp Tyr Arg Cys Glu Pro Pro Arg Pro Ala Phe Phe Phe Phe Phe Ser 
1               5                   10                  15      


Phe Leu Arg Trp Ser Phe Thr Leu Val Ala Gln Ala Gly Val Arg Trp 
            20                  25                  30          


Leu Thr Tyr Asp His Ile Thr Val Arg Gln Pro Gly 
        35                  40                  


<210>  6071
<211>  763
<212>  DNA
<213>  Homosapiens

<400>  6071
agctagcata tttggcagct tattgcttcg aaacccagct ggtcaccaaa agcttgatat     60

gacagagaag aagaaggctc aagaatttat tcaccagttc ctctgcaacc cactctgagc    120

ctctctctcc tcctatttta cttgaggctg ccaattacca gccccacctg tttcagctca    180

agagatgcct taagataatt atgtgaggcc acttggtagc aagaatggca gctatttcct    240

gagcctagta ccccaattaa gcccaccatt ggttagcaca ctcagcgctg tgagtcgtga    300

agacacggga gaaaatccac cataataaaa ctgacattca attttcaact ttagttattt    360

aacacagatt tttttatttt ttattttttt ttattttgag acggagtttt gctctgtcgc    420

gcagggtgga gtgcggtggc acgatctcgg ctcactgcaa cctctgcctc ctgggtgcaa    480

gcaattatcc tgcctcagcc tcccttactt gggaggctga cgtgggtggc tcacttgagc    540

acaggagttt gaggctgcag tgacctatga ccacatcact gtacgccagc ccgggtgaga    600

gagggagacc ccgtctctaa aaataaaatg taaaatcact gaaaaaatga gtgttcggtg    660

aaacaagtgg gattttctgg gccagcaagt cttccaaact gtatatgatg catcctgtct    720

ccatgtgtaa tatattttaa tgataaatgt atttttaaca gtg                      763


<210>  6072
<211>  66
<212>  PRT
<213>  Homosapiens

<400>  6072

His Arg Phe Phe Tyr Phe Leu Phe Phe Phe Ile Leu Arg Arg Ser Phe 
1               5                   10                  15      


Ala Leu Ser Arg Arg Val Glu Cys Gly Gly Thr Ile Ser Ala His Cys 
            20                  25                  30          


Asn Leu Cys Leu Leu Gly Ala Ser Asn Tyr Pro Ala Ser Ala Ser Leu 
        35                  40                  45              


Thr Trp Glu Ala Asp Val Gly Gly Ser Leu Glu His Arg Ser Leu Arg 
    50                  55                  60                  


Leu Gln 
65      


<210>  6073
<211>  2272
<212>  DNA
<213>  Homosapiens

<400>  6073
agtactcatt gatcagggcc tgatcaaccc ttctaattat gctcctgcca aaattgactt     60

ctcataaagt gttctctcta cttacttcac tatttccctt ctcctgccct ttttttatac    120

tttctttgct ctcaccccag ttattaacct ctgtaagtcc cattttgtct tacattcaag    180

acccaactaa aatgtcttat ttctttcagt cttataggaa catgtagtta aaagtttgac    240

ttctaaattc atgttgcatt tgacccgtac ctctcttttg atacttatgc caagtggtaa    300

gcaaccagtt ttctgtgcac agtctttctc gtgcacttgg atcgtgtata cagttcttgg    360

actatagtag gcacttgaga aatgattcag tgaacaaaag acaaatcccg gttcttcctc    420

tttcaggtca tttctactct ccccatattc cacaaaaatg tcttccacta cttgatggcg    480

tttttgcgag aactgctgaa aaattcagca aaaaatcatt tggatgagaa tattctagct    540

agcatatttg gcagcttatt gcttcgaaac ccagctggtc accaaaagct tgatatgaca    600

gagaagaaga aggctcaaga atttattcac cagttcctct gcaacccact ctgagcctct    660

ctctcctcct attttacttg aggctgccaa ttaccagccc cacctgtttc agctcaagag    720

atgccttaag ataattatgt gaggccactt ggtagcaaga atggcagcta tttcctgagc    780

ctagtacccc aattaagccc accattggtt agcacactca gcgctgtgag tcgtgaagac    840

acgggagaaa atccaccata ataaaactga cattcaattt tcaactttag ttatttaaca    900

cagatttttt tattttttat ttttttttat tttgagacgg agttttgctc tgtcgcgcag    960

ggtggagtgc ggtggcacga tctcggctca ctgcaacctc tgcctcctgg gtgcaagcaa   1020

ttatcctgcc tcagcctccc gagtagctgg gactgcaggc acacactgcc acgcccagct   1080

aattttttgc attttagtag agacggggtt tcaccgtgtt gcccaggctg ttctaaaact   1140

cctgaactca ggtaatctgc ctgcctcggc ctccccaagt gctaggatta cagatgtgag   1200

ccaccacgcc cggccttttt tttttttttt tcttttttga gatggagttt cactcttgtt   1260

gcccaggctg gagtgcgttg gcgtggtctt ggctcactgc aacctctgcc tccttggttc   1320

aagcaattct cctgcctcag cctctcgagt agctgggatt ataggcgtcc gccaccatgc   1380

ctggctaatt tttttgtgtg tttttagtat agacacggtt tcaccatgtt ggccaggctg   1440

gtctcgaatg cctggcctca ggtgatccac ctgccttggc ctcccaaagt gctgggatta   1500

caggcatgaa ccaccacgcc tggcctaaaa tgtttttaaa taactgtact tgtactcact   1560

caccctacct ccagggcata gtcagtctgg gctgagatcc ccatgatcag atatttgatg   1620

gaaagtcctg aaaggccaat gagttggatg gcaagaatgc aggcagaagc tgctggataa   1680

aataggctac agccacctca gatgctttca gtgctctgtc tgaggatgtg tatatgcata   1740

tgcaaactcg acccccgttc ctgcccagat aatggctcaa taactctgag gctggttgct   1800

cagcctctga gggcaataca ggcatttaaa aaattaaaat gaccaggcac agtggctcac   1860

gcctgtaatc tcggcacttt gggagactga ggtgggagca tcacttgaga ccaggagttt   1920

gggaccaggc tgggcaacac agggagaccc cctctctaca aaaacatttt taaaaaatta   1980

gctgggtgtg gtgatgcatg cctgtggtcc cagttacttg ggaggctgac gtgggtggct   2040

cacttgagca caggagtttg aggctgcagt gacctatgac cacatcactg tacgccagcc   2100

cgggtgagag agggagaccc cgtctctaaa aataaaatgt aaaatcactg aaaaaatgag   2160

tgttcggtga aacaagtggg attttctggg ccagcaagtc ttccaaactg tatatgatgc   2220

atcctgtctc catgtgtaat atattttaat gataaatgta tttttaacag tg           2272


<210>  6074
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  6074

Met Ala Phe Leu Arg Glu Leu Leu Lys Asn Ser Ala Lys Asn His Leu 
1               5                   10                  15      


Asp Glu Asn Ile Leu Ala Ser Ile Phe Gly Ser Leu Leu Leu Arg Asn 
            20                  25                  30          


Pro Ala Gly His Gln Lys Leu Asp Met Thr Glu Lys Lys Lys Ala Gln 
        35                  40                  45              


Glu Phe Ile His Gln Phe Leu Cys Asn Pro Leu 
    50                  55                  


<210>  6075
<211>  3905
<212>  DNA
<213>  Homosapiens

<400>  6075
gcggcgggat gaggagcttg aggaagcagg cagggaaatg tctgccgccg ccggctctcg     60

ggagcgcaac actgcaggtg gttctaactt tgatggtttg agaccaaatg ggaagggagt    120

gcctatggac caaagctcca ggggtcaaga taaaccagaa agcttgcaac caagacagaa    180

taaatccaag tccgaaatta ctgacatggt tcgctcctcc actatcacag tgtcggacaa    240

ggctcatatt ttatccatgc agaagtttgg actgcgagat acaattgtga aatcacatct    300

actacagaaa gaagaggatt acacctatat ccagaacttc aggttttttg cgggaacata    360

caatgtaaat gggcagtccc ccaaagaatg cctccggctg tggctgagca atggtatcca    420

ggccccagat gtctattgtg tagggttcca ggagcttgat ctgagtaagg aagctttttt    480

ctttcacgat accccaaagg aggaagagtg gttcaaagct gtgtcagagg gtcttcatcc    540

agatgccaaa tatgcaaagg tgaagcttat ccgactggtt gggattatgc tgctgttata    600

tgtcaaacag gagcatgcag cttatatctc agaagtggaa gccgagactg tggggacagg    660

aatcatgggg aggatgggca acaagggagg cgtggcgatc aggttccagt tccacaacac    720

cagcatctgc gttgtgaatt ctcacttggc agcccacatt gaagagtatg agaggaggaa    780

ccaggactat aaggacattt gttctcgaat gcagttttgt cagcctgacc caagccttcc    840

ccctctcacc atcagcaacc atgatgtgat cttgtggctg ggggacctca actacaggat    900

agaagagctg gatgtggaaa aagtgaaaaa gctcatcgaa gagaaggact ttcaaatgct    960

gtatgcatat gatcagctga aaattcaggt ggccgcaaag actgtctttg aaggcttcac   1020

agagggtgag ctcacattcc agcctactta caagtatgat acgggctctg acgactggga   1080

taccagtgag aagtgccgtg ctcctgcctg gtgtgatcgg attctctgga aagggaagaa   1140

catcactcag ctgagttacc agagccacat ggccctgaag accagtgacc acaagcctgt   1200

cagctcagtg tttgacatcg gggtgagggt cgtaaatgac gagctttacc ggaagacact   1260

ggaggaaatt gttcgctccc tggataagat ggaaaatgcc aacattcctt ctgtgtccct   1320

gtccaagcga gagttctgtt ttcagaatgt gaagtacatg caattgaaag tagaatcctt   1380

tacaattcat aatggacaag taccctgtca ttttgaattc atcaacaagc ctgatgaaga   1440

gtcttactgt aagcagtggc tgaatgccaa ccccagcaga ggcttcctcc tgccagattc   1500

tgatgttgag attgacttgg agctcttcgt aaataagatg acagctacaa agctcaactc   1560

gggtgaagac aaaattgagg acattctggt tctgcacttg gacaggggaa aggattactt   1620

tttgtctgtg tctgggaact acctgcccag ctgttttggg tctcccattc atacactgtg   1680

ttacatgaga gagccaatct tggacctacc acttgaaacc attagtgagc tgactctgat   1740

gccagtatgg actggagatg atgggagcca gttggatagc cccatggaaa tccccaaaga   1800

gctctggatg atggttgatt acctgtaccg aaatgctgtc cagcaggaag atctgtttca   1860

gcaaccaggc ctgaggtcag aatttgaaca tatcagggac tgcttggata ctggaatgat   1920

tgataacctc tctgccagca atcattctgt agccgaagcc ctgctgcttt tcctggagag   1980

ccttccagag cctgtcatct gttacagcac ctaccataac tgcttggagt gttctggcaa   2040

ctacacagca agcaaacagg tcatttctac tctccccata ttccacaaaa atgtcttcca   2100

ctacttgatg gcgtttttgc gagaactgct gaaaaattca gcaaaaaatc atttggatga   2160

gaatattcta gctagcatat ttggcagctt attgcttcga aacccagctg gtcaccaaaa   2220

gcttgatatg acagagaaga agaaggctca agaatttatt caccagttcc tctgcaaccc   2280

actctgagcc tctctctcct cctattttac ttgaggctgc caattaccag ccccacctgt   2340

ttcagctcaa gagatgcctt aagataatta tgtgaggcca cttggtagca agaatggcag   2400

ctatttcctg agcctagtac cccaattaag cccaccattg gttagcacac tcagcgctgt   2460

gagtcgtgaa gacacgggag aaaatccacc ataataaaac tgacattcaa ttttcaactt   2520

tagttattta acacagattt ttttattttt tatttttttt tattttgaga cggagttttg   2580

ctctgtcgcg cagggtggag tgcggtggca cgatctcggc tcactgcaac ctctgcctcc   2640

tgggtgcaag caattatcct gcctcagcct cccgagtagc tgggactgca ggcacacact   2700

gccacgccca gctaattttt tgcattttag tagagacggg gtttcaccgt gttgcccagg   2760

ctgttctaaa actcctgaac tcaggtaatc tgcctgcctc ggcctcccca agtgctagga   2820

ttacagatgt gagccaccac gcccggcctt tttttttttt ttttcttttt tgagatggag   2880

tttcactctt gttgcccagg ctggagtgcg ttggcgtggt cttggctcac tgcaacctct   2940

gcctccttgg ttcaagcaat tctcctgcct cagcctctcg agtagctggg attataggcg   3000

tccgccacca tgcctggcta atttttttgt gtgtttttag tatagacacg gtttcaccat   3060

gttggccagg ctggtctcga atgcctggcc tcaggtgatc cacctgcctt ggcctcccaa   3120

agtgctggga ttacaggcat gaaccaccac gcctggccta aaatgttttt aaataactgt   3180

acttgtactc actcacccta cctccagggc atagtcagtc tgggctgaga tccccatgat   3240

cagatatttg atggaaagtc ctgaaaggcc aatgagttgg atggcaagaa tgcaggcaga   3300

agctgctgga taaaataggc tacagccacc tcagatgctt tcagtgctct gtctgaggat   3360

gtgtatatgc atatgcaaac tcgacccccg ttcctgccca gataatggct caataactct   3420

gaggctggtt gctcagcctc tgagggcaat acaggcattt aaaaaattaa aatgaccagg   3480

cacagtggct cacgcctgta atctcggcac tttgggagac tgaggtggga gcatcacttg   3540

agaccaggag tttgggacca ggctgggcaa cacagggaga ccccctctct acaaaaacat   3600

ttttaaaaaa ttagctgggt gtggtgatgc atgcctgtgg tcccagttac ttgggaggct   3660

gacgtgggtg gctcacttga gcacaggagt ttgaggctgc agtgacctat gaccacatca   3720

ctgtacgcca gcccgggtga gagagggaga ccccgtctct aaaaataaaa tgtaaaatca   3780

ctgaaaaaat gagtgttcgg tgaaacaagt gggattttct gggccagcaa gtcttccaaa   3840

ctgtatatga tgcatcctgt ctccatgtgt aatatatttt aatgataaat gtatttttaa   3900

cagtg                                                               3905


<210>  6076
<211>  749
<212>  PRT
<213>  Homosapiens

<400>  6076

Met Ser Ala Ala Ala Gly Ser Arg Glu Arg Asn Thr Ala Gly Gly Ser 
1               5                   10                  15      


Asn Phe Asp Gly Leu Arg Pro Asn Gly Lys Gly Val Pro Met Asp Gln 
            20                  25                  30          


Ser Ser Arg Gly Gln Asp Lys Pro Glu Ser Leu Gln Pro Arg Gln Asn 
        35                  40                  45              


Lys Ser Lys Ser Glu Ile Thr Asp Met Val Arg Ser Ser Thr Ile Thr 
    50                  55                  60                  


Val Ser Asp Lys Ala His Ile Leu Ser Met Gln Lys Phe Gly Leu Arg 
65                  70                  75                  80  


Asp Thr Ile Val Lys Ser His Leu Leu Gln Lys Glu Glu Asp Tyr Thr 
                85                  90                  95      


Tyr Ile Gln Asn Phe Arg Phe Phe Ala Gly Thr Tyr Asn Val Asn Gly 
            100                 105                 110         


Gln Ser Pro Lys Glu Cys Leu Arg Leu Trp Leu Ser Asn Gly Ile Gln 
        115                 120                 125             


Ala Pro Asp Val Tyr Cys Val Gly Phe Gln Glu Leu Asp Leu Ser Lys 
    130                 135                 140                 


Glu Ala Phe Phe Phe His Asp Thr Pro Lys Glu Glu Glu Trp Phe Lys 
145                 150                 155                 160 


Ala Val Ser Glu Gly Leu His Pro Asp Ala Lys Tyr Ala Lys Val Lys 
                165                 170                 175     


Leu Ile Arg Leu Val Gly Ile Met Leu Leu Leu Tyr Val Lys Gln Glu 
            180                 185                 190         


His Ala Ala Tyr Ile Ser Glu Val Glu Ala Glu Thr Val Gly Thr Gly 
        195                 200                 205             


Ile Met Gly Arg Met Gly Asn Lys Gly Gly Val Ala Ile Arg Phe Gln 
    210                 215                 220                 


Phe His Asn Thr Ser Ile Cys Val Val Asn Ser His Leu Ala Ala His 
225                 230                 235                 240 


Ile Glu Glu Tyr Glu Arg Arg Asn Gln Asp Tyr Lys Asp Ile Cys Ser 
                245                 250                 255     


Arg Met Gln Phe Cys Gln Pro Asp Pro Ser Leu Pro Pro Leu Thr Ile 
            260                 265                 270         


Ser Asn His Asp Val Ile Leu Trp Leu Gly Asp Leu Asn Tyr Arg Ile 
        275                 280                 285             


Glu Glu Leu Asp Val Glu Lys Val Lys Lys Leu Ile Glu Glu Lys Asp 
    290                 295                 300                 


Phe Gln Met Leu Tyr Ala Tyr Asp Gln Leu Lys Ile Gln Val Ala Ala 
305                 310                 315                 320 


Lys Thr Val Phe Glu Gly Phe Thr Glu Gly Glu Leu Thr Phe Gln Pro 
                325                 330                 335     


Thr Tyr Lys Tyr Asp Thr Gly Ser Asp Asp Trp Asp Thr Ser Glu Lys 
            340                 345                 350         


Cys Arg Ala Pro Ala Trp Cys Asp Arg Ile Leu Trp Lys Gly Lys Asn 
        355                 360                 365             


Ile Thr Gln Leu Ser Tyr Gln Ser His Met Ala Leu Lys Thr Ser Asp 
    370                 375                 380                 


His Lys Pro Val Ser Ser Val Phe Asp Ile Gly Val Arg Val Val Asn 
385                 390                 395                 400 


Asp Glu Leu Tyr Arg Lys Thr Leu Glu Glu Ile Val Arg Ser Leu Asp 
                405                 410                 415     


Lys Met Glu Asn Ala Asn Ile Pro Ser Val Ser Leu Ser Lys Arg Glu 
            420                 425                 430         


Phe Cys Phe Gln Asn Val Lys Tyr Met Gln Leu Lys Val Glu Ser Phe 
        435                 440                 445             


Thr Ile His Asn Gly Gln Val Pro Cys His Phe Glu Phe Ile Asn Lys 
    450                 455                 460                 


Pro Asp Glu Glu Ser Tyr Cys Lys Gln Trp Leu Asn Ala Asn Pro Ser 
465                 470                 475                 480 


Arg Gly Phe Leu Leu Pro Asp Ser Asp Val Glu Ile Asp Leu Glu Leu 
                485                 490                 495     


Phe Val Asn Lys Met Thr Ala Thr Lys Leu Asn Ser Gly Glu Asp Lys 
            500                 505                 510         


Ile Glu Asp Ile Leu Val Leu His Leu Asp Arg Gly Lys Asp Tyr Phe 
        515                 520                 525             


Leu Ser Val Ser Gly Asn Tyr Leu Pro Ser Cys Phe Gly Ser Pro Ile 
    530                 535                 540                 


His Thr Leu Cys Tyr Met Arg Glu Pro Ile Leu Asp Leu Pro Leu Glu 
545                 550                 555                 560 


Thr Ile Ser Glu Leu Thr Leu Met Pro Val Trp Thr Gly Asp Asp Gly 
                565                 570                 575     


Ser Gln Leu Asp Ser Pro Met Glu Ile Pro Lys Glu Leu Trp Met Met 
            580                 585                 590         


Val Asp Tyr Leu Tyr Arg Asn Ala Val Gln Gln Glu Asp Leu Phe Gln 
        595                 600                 605             


Gln Pro Gly Leu Arg Ser Glu Phe Glu His Ile Arg Asp Cys Leu Asp 
    610                 615                 620                 


Thr Gly Met Ile Asp Asn Leu Ser Ala Ser Asn His Ser Val Ala Glu 
625                 630                 635                 640 


Ala Leu Leu Leu Phe Leu Glu Ser Leu Pro Glu Pro Val Ile Cys Tyr 
                645                 650                 655     


Ser Thr Tyr His Asn Cys Leu Glu Cys Ser Gly Asn Tyr Thr Ala Ser 
            660                 665                 670         


Lys Gln Val Ile Ser Thr Leu Pro Ile Phe His Lys Asn Val Phe His 
        675                 680                 685             


Tyr Leu Met Ala Phe Leu Arg Glu Leu Leu Lys Asn Ser Ala Lys Asn 
    690                 695                 700                 


His Leu Asp Glu Asn Ile Leu Ala Ser Ile Phe Gly Ser Leu Leu Leu 
705                 710                 715                 720 


Arg Asn Pro Ala Gly His Gln Lys Leu Asp Met Thr Glu Lys Lys Lys 
                725                 730                 735     


Ala Gln Glu Phe Ile His Gln Phe Leu Cys Asn Pro Leu 
            740                 745                 


<210>  6077
<211>  4000
<212>  DNA
<213>  Homosapiens

<400>  6077
cccggaacct ggggcagcgg agtcccgtgc gccctgtggt gacagctcag gagggtgtgt     60

gcgctcagca ggggccagca tggaccagtc tgtggcaatc caggagacgc tggctgaggg    120

ggaatactgc gtcatcgcgg tgcaaggtgt gctgtgtgag ggggacagcc ggcagagccg    180

cctcctggga ctcgtgcgct accgcctgga gcacggcggc caggaacacg ctctcttcct    240

ctatacgcac cggaggatgg ccattaccgg ggacgatgtc tctctggacc agatagtgcc    300

agtctcgcgg gattttacgc tggaagaagt gtccccagat ggtgaactct acatccttgg    360

ctcagatgtg accgtccagc tggacacagc agagcttagc ctcgtattcc aactgccctt    420

tggttcacaa accaggatgt tcctccacga agttgccagg gcctgtccag gcttcgattc    480

tgcgacccgg gatcctgaat tcctgtggct gtctcggtat aggtgcgcag agctggagct    540

ggagatgcca acgccgcgcg gttgtaactc ggccctagtt acctggccag ggtacgcgac    600

aattggcgga ggtggttcta actttgatgg tttgagacca aatgggaagg gagtgcctat    660

ggaccaaagc tccaggggtc aagataaacc agaaagcttg caaccaagac agaataaatc    720

caagtccgaa attactgaca tggttcgctc ctccactatc acagtgtcgg acaaggctca    780

tattttatcc atgcagaagt ttggactgcg agatacaatt gtgaaatcac atctactaca    840

gaaagaagag gattacacct atatccagaa cttcaggttt tttgcgggaa catacaatgt    900

aaatgggcag tcccccaaag aatgcctccg gctgtggctg agcaatggta tccaggcccc    960

agatgtctat tgtgtagggt tccaggagct tgatctgagt aaggaagctt ttttctttca   1020

cgatacccca aaggaggaag agtggttcaa agctgtgtca gagggtcttc atccagatgc   1080

caaatatgca aaggtgaagc ttatccgact ggttgggatt atgctgctgt tatatgtcaa   1140

acaggagcat gcagcttata tctcagaagt ggaagccgag actgtgggga caggaatcat   1200

ggggaggatg ggcaacaagg gaggcgtggc gatcaggttc cagttccaca acaccagcat   1260

ctgcgttgtg aattctcact tggcagccca cattgaagag tatgagagga ggaaccagga   1320

ctataaggac atttgttctc gaatgcagtt ttgtcagcct gacccaagcc ttccccctct   1380

caccatcagc aaccatgatg tgatcttgtg gctgggggac ctcaactaca ggatagaaga   1440

gctggatgtg gaaaaagtga aaaagctcat cgaagagaag gactttcaaa tgctgtatgc   1500

atatgatcag ctgaaaattc aggtggccgc aaagactgtc tttgaaggct tcacagaggg   1560

tgagctcaca ttccagccta cttacaagta tgatacgggc tctgacgact gggataccag   1620

tgagaagtgc cgtgctcctg cctggtgtga tcggattctc tggaaaggga agaacatcac   1680

tcagctgagt taccagagcc acatggccct gaagaccagt gaccacaagc ctgtcagctc   1740

agtgtttgac atcggggtga gggtcgtaaa tgacgagctt taccggaaga cactggagga   1800

aattgttcgc tccctggata agatggaaaa tgccaacatt ccttctgtgt ccctgtccaa   1860

gcgagagttc tgttttcaga atgtgaagta catgcaattg aaagtagaat cctttacaat   1920

tcataatgga caagtaccct gtcattttga attcatcaac aagcctgatg aagagtctta   1980

ctgtaagcag tggctgaatg ccaaccccag cagaggcttc ctcctgccag attctgatgt   2040

tgagattgac ttggagctct tcgtaaataa gatgacagct acaaagctca actcgggtga   2100

agacaaaatt gaggacattc tggttctgca cttggacagg ggaaaggatt actttttgtc   2160

tgtgtctggg aactacctgc ccagctgttt tgggtctccc attcatacac tgtgttacat   2220

gagagagcca atcttggacc taccacttga aaccattagt gagctgctag catatttggc   2280

agcttattgc ttcgaaaccc agctggtcac caaaagcttg atatgacaga gaagaagaag   2340

gctcaagaat ttattcacca gttcctctgc aacccactct gagcctctct ctcctcctat   2400

tttacttgag gctgccaatt accagcccca cctgtttcag ctcaagagat gccttaagat   2460

aattatgtga ggccacttgg tagcaagaat ggcagctatt tcctgagcct agtaccccaa   2520

ttaagcccac cattggttag cacactcagc gctgtgagtc gtgaagacac gggagaaaat   2580

ccaccataat aaaactgaca ttcaattttc aactttagtt atttaacaca gattttttta   2640

ttttttattt ttttttattt tgagacggag ttttgctctg tcgcgcaggg tggagtgcgg   2700

tggcacgatc tcggctcact gcaacctctg cctcctgggt gcaagcaatt atcctgcctc   2760

agcctcccga gtagctggga ctgcaggcac acactgccac gcccagctaa ttttttgcat   2820

tttagtagag acggggtttc accgtgttgc ccaggctgtt ctaaaactcc tgaactcagg   2880

taatctgcct gcctcggcct ccccaagtgc taggattaca gatgtgagcc accacgcccg   2940

gccttttttt tttttttttc ttttttgaga tggagtttca ctcttgttgc ccaggctgga   3000

gtgcgttggc gtggtcttgg ctcactgcaa cctctgcctc cttggttcaa gcaattctcc   3060

tgcctcagcc tctcgagtag ctgggattat aggcgtccgc caccatgcct ggctaatttt   3120

tttgtgtgtt tttagtatag acacggtttc accatgttgg ccaggctggt ctcgaatgcc   3180

tggcctcagg tgatccacct gccttggcct cccaaagtgc tgggattaca ggcatgaacc   3240

accacgcctg gcctaaaatg tttttaaata actgtacttg tactcactca ccctacctcc   3300

agggcatagt cagtctgggc tgagatcccc atgatcagat atttgatgga aagtcctgaa   3360

aggccaatga gttggatggc aagaatgcag gcagaagctg ctggataaaa taggctacag   3420

ccacctcaga tgctttcagt gctctgtctg aggatgtgta tatgcatatg caaactcgac   3480

ccccgttcct gcccagataa tggctcaata actctgaggc tggttgctca gcctctgagg   3540

gcaatacagg catttaaaaa attaaaatga ccaggcacag tggctcacgc ctgtaatctc   3600

ggcactttgg gagactgagg tgggagcatc acttgagacc aggagtttgg gaccaggctg   3660

ggcaacacag ggagaccccc tctctacaaa aacattttta aaaaattagc tgggtgtggt   3720

gatgcatgcc tgtggtccca gttacttggg aggctgacgt gggtggctca cttgagcaca   3780

ggagtttgag gctgcagtga cctatgacca catcactgta cgccagcccg ggtgagagag   3840

ggagaccccg tctctaaaaa taaaatgtaa aatcactgaa aaaatgagtg ttcggtgaaa   3900

caagtgggat tttctgggcc agcaagtctt ccaaactgta tatgatgcat cctgtctcca   3960

tgtgtaatat attttaatga taaatgtatt tttaacagtg                         4000


<210>  6078
<211>  748
<212>  PRT
<213>  Homosapiens

<400>  6078

Met Asp Gln Ser Val Ala Ile Gln Glu Thr Leu Ala Glu Gly Glu Tyr 
1               5                   10                  15      


Cys Val Ile Ala Val Gln Gly Val Leu Cys Glu Gly Asp Ser Arg Gln 
            20                  25                  30          


Ser Arg Leu Leu Gly Leu Val Arg Tyr Arg Leu Glu His Gly Gly Gln 
        35                  40                  45              


Glu His Ala Leu Phe Leu Tyr Thr His Arg Arg Met Ala Ile Thr Gly 
    50                  55                  60                  


Asp Asp Val Ser Leu Asp Gln Ile Val Pro Val Ser Arg Asp Phe Thr 
65                  70                  75                  80  


Leu Glu Glu Val Ser Pro Asp Gly Glu Leu Tyr Ile Leu Gly Ser Asp 
                85                  90                  95      


Val Thr Val Gln Leu Asp Thr Ala Glu Leu Ser Leu Val Phe Gln Leu 
            100                 105                 110         


Pro Phe Gly Ser Gln Thr Arg Met Phe Leu His Glu Val Ala Arg Ala 
        115                 120                 125             


Cys Pro Gly Phe Asp Ser Ala Thr Arg Asp Pro Glu Phe Leu Trp Leu 
    130                 135                 140                 


Ser Arg Tyr Arg Cys Ala Glu Leu Glu Leu Glu Met Pro Thr Pro Arg 
145                 150                 155                 160 


Gly Cys Asn Ser Ala Leu Val Thr Trp Pro Gly Tyr Ala Thr Ile Gly 
                165                 170                 175     


Gly Gly Gly Ser Asn Phe Asp Gly Leu Arg Pro Asn Gly Lys Gly Val 
            180                 185                 190         


Pro Met Asp Gln Ser Ser Arg Gly Gln Asp Lys Pro Glu Ser Leu Gln 
        195                 200                 205             


Pro Arg Gln Asn Lys Ser Lys Ser Glu Ile Thr Asp Met Val Arg Ser 
    210                 215                 220                 


Ser Thr Ile Thr Val Ser Asp Lys Ala His Ile Leu Ser Met Gln Lys 
225                 230                 235                 240 


Phe Gly Leu Arg Asp Thr Ile Val Lys Ser His Leu Leu Gln Lys Glu 
                245                 250                 255     


Glu Asp Tyr Thr Tyr Ile Gln Asn Phe Arg Phe Phe Ala Gly Thr Tyr 
            260                 265                 270         


Asn Val Asn Gly Gln Ser Pro Lys Glu Cys Leu Arg Leu Trp Leu Ser 
        275                 280                 285             


Asn Gly Ile Gln Ala Pro Asp Val Tyr Cys Val Gly Phe Gln Glu Leu 
    290                 295                 300                 


Asp Leu Ser Lys Glu Ala Phe Phe Phe His Asp Thr Pro Lys Glu Glu 
305                 310                 315                 320 


Glu Trp Phe Lys Ala Val Ser Glu Gly Leu His Pro Asp Ala Lys Tyr 
                325                 330                 335     


Ala Lys Val Lys Leu Ile Arg Leu Val Gly Ile Met Leu Leu Leu Tyr 
            340                 345                 350         


Val Lys Gln Glu His Ala Ala Tyr Ile Ser Glu Val Glu Ala Glu Thr 
        355                 360                 365             


Val Gly Thr Gly Ile Met Gly Arg Met Gly Asn Lys Gly Gly Val Ala 
    370                 375                 380                 


Ile Arg Phe Gln Phe His Asn Thr Ser Ile Cys Val Val Asn Ser His 
385                 390                 395                 400 


Leu Ala Ala His Ile Glu Glu Tyr Glu Arg Arg Asn Gln Asp Tyr Lys 
                405                 410                 415     


Asp Ile Cys Ser Arg Met Gln Phe Cys Gln Pro Asp Pro Ser Leu Pro 
            420                 425                 430         


Pro Leu Thr Ile Ser Asn His Asp Val Ile Leu Trp Leu Gly Asp Leu 
        435                 440                 445             


Asn Tyr Arg Ile Glu Glu Leu Asp Val Glu Lys Val Lys Lys Leu Ile 
    450                 455                 460                 


Glu Glu Lys Asp Phe Gln Met Leu Tyr Ala Tyr Asp Gln Leu Lys Ile 
465                 470                 475                 480 


Gln Val Ala Ala Lys Thr Val Phe Glu Gly Phe Thr Glu Gly Glu Leu 
                485                 490                 495     


Thr Phe Gln Pro Thr Tyr Lys Tyr Asp Thr Gly Ser Asp Asp Trp Asp 
            500                 505                 510         


Thr Ser Glu Lys Cys Arg Ala Pro Ala Trp Cys Asp Arg Ile Leu Trp 
        515                 520                 525             


Lys Gly Lys Asn Ile Thr Gln Leu Ser Tyr Gln Ser His Met Ala Leu 
    530                 535                 540                 


Lys Thr Ser Asp His Lys Pro Val Ser Ser Val Phe Asp Ile Gly Val 
545                 550                 555                 560 


Arg Val Val Asn Asp Glu Leu Tyr Arg Lys Thr Leu Glu Glu Ile Val 
                565                 570                 575     


Arg Ser Leu Asp Lys Met Glu Asn Ala Asn Ile Pro Ser Val Ser Leu 
            580                 585                 590         


Ser Lys Arg Glu Phe Cys Phe Gln Asn Val Lys Tyr Met Gln Leu Lys 
        595                 600                 605             


Val Glu Ser Phe Thr Ile His Asn Gly Gln Val Pro Cys His Phe Glu 
    610                 615                 620                 


Phe Ile Asn Lys Pro Asp Glu Glu Ser Tyr Cys Lys Gln Trp Leu Asn 
625                 630                 635                 640 


Ala Asn Pro Ser Arg Gly Phe Leu Leu Pro Asp Ser Asp Val Glu Ile 
                645                 650                 655     


Asp Leu Glu Leu Phe Val Asn Lys Met Thr Ala Thr Lys Leu Asn Ser 
            660                 665                 670         


Gly Glu Asp Lys Ile Glu Asp Ile Leu Val Leu His Leu Asp Arg Gly 
        675                 680                 685             


Lys Asp Tyr Phe Leu Ser Val Ser Gly Asn Tyr Leu Pro Ser Cys Phe 
    690                 695                 700                 


Gly Ser Pro Ile His Thr Leu Cys Tyr Met Arg Glu Pro Ile Leu Asp 
705                 710                 715                 720 


Leu Pro Leu Glu Thr Ile Ser Glu Leu Leu Ala Tyr Leu Ala Ala Tyr 
                725                 730                 735     


Cys Phe Glu Thr Gln Leu Val Thr Lys Ser Leu Ile 
            740                 745             


<210>  6079
<211>  882
<212>  DNA
<213>  Homosapiens

<400>  6079
agtactcatt gatcagggcc tgatcaaccc ttctaattat gctcctgcca aaattgactt     60

ctcataaagt gttctctcta cttacttcac tatttccctt ctcctgccct ttttttatac    120

tttctttgct ctcaccccag ttattaacct ctgtaagtcc cattttgtct tacattcaag    180

acccaactaa aatgtcttat ttctttcagt cttataggaa catgtagtta aaagtttgac    240

ttctaaattc atgttgcatt tgacccgtac ctctcttttg atacttatgc caagtggtaa    300

gcaaccagtt ttctgtgcac agtctttctc gtgcacttgg atcgtgtata cagttcttgg    360

actatagtag gcacttgaga aatgattcag tgaacaaaag acaaatcccg gttcttcctc    420

tttcaggtca tttctactct ccccatattc cacaaaaatg tcttccacta cttgatggcg    480

tttttgcgag aactgctgaa aaattcagca aaaaatcatt tggatgagaa tattctagct    540

agcatatttg gcagcttatt gcttcgaaac ccagctggtc accaaaagct tgatatgaca    600

gagaagaaga aggctcaaga atttattcac cagttcctct gcaacccact ctgagcctct    660

ctctcctcct attttacttg aggctgccaa ttaccagccc cacctgtttc agctcaagag    720

atgccttaag ataattatgt gaggccactt ggtagcaaga atggcagcta tttcctgagc    780

ctagtacccc aattaagccc accattggtt agcacactca gcgctgtgag tcgtgaagac    840

acgggagaaa atccaccata ataaaactga cattcaattt tc                       882


<210>  6080
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  6080

Met Ala Phe Leu Arg Glu Leu Leu Lys Asn Ser Ala Lys Asn His Leu 
1               5                   10                  15      


Asp Glu Asn Ile Leu Ala Ser Ile Phe Gly Ser Leu Leu Leu Arg Asn 
            20                  25                  30          


Pro Ala Gly His Gln Lys Leu Asp Met Thr Glu Lys Lys Lys Ala Gln 
        35                  40                  45              


Glu Phe Ile His Gln Phe Leu Cys Asn Pro Leu 
    50                  55                  


<210>  6081
<211>  2515
<212>  DNA
<213>  Homosapiens

<400>  6081
gcggcgggat gaggagcttg aggaagcagg cagggaaatg tctgccgccg ccggctctcg     60

ggagcgcaac actgcaggtg gttctaactt tgatggtttg agaccaaatg ggaagggagt    120

gcctatggac caaagctcca ggggtcaaga taaaccagaa agcttgcaac caagacagaa    180

taaatccaag tccgaaatta ctgacatggt tcgctcctcc actatcacag tgtcggacaa    240

ggctcatatt ttatccatgc agaagtttgg actgcgagat acaattgtga aatcacatct    300

actacagaaa gaagaggatt acacctatat ccagaacttc aggttttttg cgggaacata    360

caatgtaaat gggcagtccc ccaaagaatg cctccggctg tggctgagca atggtatcca    420

ggccccagat gtctattgtg tagggttcca ggagcttgat ctgagtaagg aagctttttt    480

ctttcacgat accccaaagg aggaagagtg gttcaaagct gtgtcagagg gtcttcatcc    540

agatgccaaa tatgcaaagg tgaagcttat ccgactggtt gggattatgc tgctgttata    600

tgtcaaacag gagcatgcag cttatatctc agaagtggaa gccgagactg tggggacagg    660

aatcatgggg aggatgggca acaagggagg cgtggcgatc aggttccagt tccacaacac    720

cagcatctgc gttgtgaatt ctcacttggc agcccacatt gaagagtatg agaggaggaa    780

ccaggactat aaggacattt gttctcgaat gcagttttgt cagcctgacc caagccttcc    840

ccctctcacc atcagcaacc atgatgtgat cttgtggctg ggggacctca actacaggat    900

agaagagctg gatgtggaaa aagtgaaaaa gctcatcgaa gagaaggact ttcaaatgct    960

gtatgcatat gatcagctga aaattcaggt ggccgcaaag actgtctttg aaggcttcac   1020

agagggtgag ctcacattcc agcctactta caagtatgat acgggctctg acgactggga   1080

taccagtgag aagtgccgtg ctcctgcctg gtgtgatcgg attctctgga aagggaagaa   1140

catcactcag ctgagttacc agagccacat ggccctgaag accagtgacc acaagcctgt   1200

cagctcagtg tttgacatcg gggtgagggt cgtaaatgac gagctttacc ggaagacact   1260

ggaggaaatt gttcgctccc tggataagat ggaaaatgcc aacattcctt ctgtgtccct   1320

gtccaagcga gagttctgtt ttcagaatgt gaagtacatg caattgaaag tagaatcctt   1380

tacaattcat aatggacaag taccctgtca ttttgaattc atcaacaagc ctgatgaaga   1440

gtcttactgt aagcagtggc tgaatgccaa ccccagcaga ggcttcctcc tgccagattc   1500

tgatgttgag attgacttgg agctcttcgt aaataagatg acagctacaa agctcaactc   1560

gggtgaagac aaaattgagg acattctggt tctgcacttg gacaggggaa aggattactt   1620

tttgtctgtg tctgggaact acctgcccag ctgttttggg tctcccattc atacactgtg   1680

ttacatgaga gagccaatct tggacctacc acttgaaacc attagtgagc tgactctgat   1740

gccagtatgg actggagatg atgggagcca gttggatagc cccatggaaa tccccaaaga   1800

gctctggatg atggttgatt acctgtaccg aaatgctgtc cagcaggaag atctgtttca   1860

gcaaccaggc ctgaggtcag aatttgaaca tatcagggac tgcttggata ctggaatgat   1920

tgataacctc tctgccagca atcattctgt agccgaagcc ctgctgcttt tcctggagag   1980

ccttccagag cctgtcatct gttacagcac ctaccataac tgcttggagt gttctggcaa   2040

ctacacagca agcaaacagg tcatttctac tctccccata ttccacaaaa atgtcttcca   2100

ctacttgatg gcgtttttgc gagaactgct gaaaaattca gcaaaaaatc atttggatga   2160

gaatattcta gctagcatat ttggcagctt attgcttcga aacccagctg gtcaccaaaa   2220

gcttgatatg acagagaaga agaaggctca agaatttatt caccagttcc tctgcaaccc   2280

actctgagcc tctctctcct cctattttac ttgaggctgc caattaccag ccccacctgt   2340

ttcagctcaa gagatgcctt aagataatta tgtgaggcca cttggtagca agaatggcag   2400

ctatttcctg agcctagtac cccaattaag cccaccattg gttagcacac tcagcgctgt   2460

gagtcgtgaa gacacgggag aaaatccacc ataataaaac tgacattcaa ttttc        2515


<210>  6082
<211>  749
<212>  PRT
<213>  Homosapiens

<400>  6082

Met Ser Ala Ala Ala Gly Ser Arg Glu Arg Asn Thr Ala Gly Gly Ser 
1               5                   10                  15      


Asn Phe Asp Gly Leu Arg Pro Asn Gly Lys Gly Val Pro Met Asp Gln 
            20                  25                  30          


Ser Ser Arg Gly Gln Asp Lys Pro Glu Ser Leu Gln Pro Arg Gln Asn 
        35                  40                  45              


Lys Ser Lys Ser Glu Ile Thr Asp Met Val Arg Ser Ser Thr Ile Thr 
    50                  55                  60                  


Val Ser Asp Lys Ala His Ile Leu Ser Met Gln Lys Phe Gly Leu Arg 
65                  70                  75                  80  


Asp Thr Ile Val Lys Ser His Leu Leu Gln Lys Glu Glu Asp Tyr Thr 
                85                  90                  95      


Tyr Ile Gln Asn Phe Arg Phe Phe Ala Gly Thr Tyr Asn Val Asn Gly 
            100                 105                 110         


Gln Ser Pro Lys Glu Cys Leu Arg Leu Trp Leu Ser Asn Gly Ile Gln 
        115                 120                 125             


Ala Pro Asp Val Tyr Cys Val Gly Phe Gln Glu Leu Asp Leu Ser Lys 
    130                 135                 140                 


Glu Ala Phe Phe Phe His Asp Thr Pro Lys Glu Glu Glu Trp Phe Lys 
145                 150                 155                 160 


Ala Val Ser Glu Gly Leu His Pro Asp Ala Lys Tyr Ala Lys Val Lys 
                165                 170                 175     


Leu Ile Arg Leu Val Gly Ile Met Leu Leu Leu Tyr Val Lys Gln Glu 
            180                 185                 190         


His Ala Ala Tyr Ile Ser Glu Val Glu Ala Glu Thr Val Gly Thr Gly 
        195                 200                 205             


Ile Met Gly Arg Met Gly Asn Lys Gly Gly Val Ala Ile Arg Phe Gln 
    210                 215                 220                 


Phe His Asn Thr Ser Ile Cys Val Val Asn Ser His Leu Ala Ala His 
225                 230                 235                 240 


Ile Glu Glu Tyr Glu Arg Arg Asn Gln Asp Tyr Lys Asp Ile Cys Ser 
                245                 250                 255     


Arg Met Gln Phe Cys Gln Pro Asp Pro Ser Leu Pro Pro Leu Thr Ile 
            260                 265                 270         


Ser Asn His Asp Val Ile Leu Trp Leu Gly Asp Leu Asn Tyr Arg Ile 
        275                 280                 285             


Glu Glu Leu Asp Val Glu Lys Val Lys Lys Leu Ile Glu Glu Lys Asp 
    290                 295                 300                 


Phe Gln Met Leu Tyr Ala Tyr Asp Gln Leu Lys Ile Gln Val Ala Ala 
305                 310                 315                 320 


Lys Thr Val Phe Glu Gly Phe Thr Glu Gly Glu Leu Thr Phe Gln Pro 
                325                 330                 335     


Thr Tyr Lys Tyr Asp Thr Gly Ser Asp Asp Trp Asp Thr Ser Glu Lys 
            340                 345                 350         


Cys Arg Ala Pro Ala Trp Cys Asp Arg Ile Leu Trp Lys Gly Lys Asn 
        355                 360                 365             


Ile Thr Gln Leu Ser Tyr Gln Ser His Met Ala Leu Lys Thr Ser Asp 
    370                 375                 380                 


His Lys Pro Val Ser Ser Val Phe Asp Ile Gly Val Arg Val Val Asn 
385                 390                 395                 400 


Asp Glu Leu Tyr Arg Lys Thr Leu Glu Glu Ile Val Arg Ser Leu Asp 
                405                 410                 415     


Lys Met Glu Asn Ala Asn Ile Pro Ser Val Ser Leu Ser Lys Arg Glu 
            420                 425                 430         


Phe Cys Phe Gln Asn Val Lys Tyr Met Gln Leu Lys Val Glu Ser Phe 
        435                 440                 445             


Thr Ile His Asn Gly Gln Val Pro Cys His Phe Glu Phe Ile Asn Lys 
    450                 455                 460                 


Pro Asp Glu Glu Ser Tyr Cys Lys Gln Trp Leu Asn Ala Asn Pro Ser 
465                 470                 475                 480 


Arg Gly Phe Leu Leu Pro Asp Ser Asp Val Glu Ile Asp Leu Glu Leu 
                485                 490                 495     


Phe Val Asn Lys Met Thr Ala Thr Lys Leu Asn Ser Gly Glu Asp Lys 
            500                 505                 510         


Ile Glu Asp Ile Leu Val Leu His Leu Asp Arg Gly Lys Asp Tyr Phe 
        515                 520                 525             


Leu Ser Val Ser Gly Asn Tyr Leu Pro Ser Cys Phe Gly Ser Pro Ile 
    530                 535                 540                 


His Thr Leu Cys Tyr Met Arg Glu Pro Ile Leu Asp Leu Pro Leu Glu 
545                 550                 555                 560 


Thr Ile Ser Glu Leu Thr Leu Met Pro Val Trp Thr Gly Asp Asp Gly 
                565                 570                 575     


Ser Gln Leu Asp Ser Pro Met Glu Ile Pro Lys Glu Leu Trp Met Met 
            580                 585                 590         


Val Asp Tyr Leu Tyr Arg Asn Ala Val Gln Gln Glu Asp Leu Phe Gln 
        595                 600                 605             


Gln Pro Gly Leu Arg Ser Glu Phe Glu His Ile Arg Asp Cys Leu Asp 
    610                 615                 620                 


Thr Gly Met Ile Asp Asn Leu Ser Ala Ser Asn His Ser Val Ala Glu 
625                 630                 635                 640 


Ala Leu Leu Leu Phe Leu Glu Ser Leu Pro Glu Pro Val Ile Cys Tyr 
                645                 650                 655     


Ser Thr Tyr His Asn Cys Leu Glu Cys Ser Gly Asn Tyr Thr Ala Ser 
            660                 665                 670         


Lys Gln Val Ile Ser Thr Leu Pro Ile Phe His Lys Asn Val Phe His 
        675                 680                 685             


Tyr Leu Met Ala Phe Leu Arg Glu Leu Leu Lys Asn Ser Ala Lys Asn 
    690                 695                 700                 


His Leu Asp Glu Asn Ile Leu Ala Ser Ile Phe Gly Ser Leu Leu Leu 
705                 710                 715                 720 


Arg Asn Pro Ala Gly His Gln Lys Leu Asp Met Thr Glu Lys Lys Lys 
                725                 730                 735     


Ala Gln Glu Phe Ile His Gln Phe Leu Cys Asn Pro Leu 
            740                 745                 


<210>  6083
<211>  3058
<212>  DNA
<213>  Homosapiens

<400>  6083
agtcactgtc ccggaacctg gggcagcgga gtcccgtgcg ccctgtggtg acagctcagg     60

agggtgtgtg cgctcagcag gggccagcat ggaccagtct gtggcaatcc aggagacgct    120

ggctgagggg gaatactgcg tcatcgcggt gcaaggtgtg ctgtgtgagg gggacagccg    180

gcagagccgc ctcctgggac tcgtgcgcta ccgcctggag cacggcggcc aggaacacgc    240

tctcttcctc tatacgcacc ggaggatggc cattaccggg gacgatgtct ctctggacca    300

gatagtgcca gtctcgcggg attttacgct ggaagaagtg tccccagatg gtgaactcta    360

catccttggc tcagatgtga ccgtccagct ggacacagca gagcttagcc tcgtattcca    420

actgcccttt ggttcacaaa ccaggatgtt cctccacgaa gttgccaggg cctgtccagg    480

cttcgattct gcgacccggg atcctgaatt cctgtggctg tctcggtata ggtgcgcaga    540

gctggagctg gagatgccaa cgccgcgcgg ttgtaactcg gccctagtta cctggccagg    600

gtacgcgaca attggcggag gtggttctaa ctttgatggt ttgagaccaa atgggaaggg    660

agtgcctatg gaccaaagct ccaggggtca agataaacca gaaagcttgc aaccaagaca    720

gaataaatcc aagtccgaaa ttactgacat ggttcgctcc tccactatca cagtgtcgga    780

caaggctcat attttatcca tgcagaagtt tggactgcga gatacaattg tgaaatcaca    840

tctactacag aaagaagagg attacaccta tatccagaac ttcaggtttt ttgcgggaac    900

atacaatgta aatgggcagt cccccaaaga atgcctccgg ctgtggctga gcaatggtat    960

ccaggcccca gatgtctatt gtgtagggtt ccaggagctt gatctgagta aggaagcttt   1020

tttctttcac gataccccaa aggaggaaga gtggttcaaa gctgtgtcag agggtcttca   1080

tccagatgcc aaatatgcaa aggtgaagct tatccgactg gttgggatta tgctgctgtt   1140

atatgtcaaa caggagcatg cagcttatat ctcagaagtg gaagccgaga ctgtggggac   1200

aggaatcatg gggaggatgg gcaacaaggg aggcgtggcg atcaggttcc agttccacaa   1260

caccagcatc tgcgttgtga attctcactt ggcagcccac attgaagagt atgagaggag   1320

gaaccaggac tataaggaca tttgttctcg aatgcagttt tgtcagcctg acccaagcct   1380

tccccctctc accatcagca accatgatgt gatcttgtgg ctgggggacc tcaactacag   1440

gatagaagag ctggatgtgg aaaaagtgaa aaagctcatc gaagagaagg actttcaaat   1500

gctgtatgca tatgatcagc tgaaaattca ggtggccgca aagactgtct ttgaaggctt   1560

cacagagggt gagctcacat tccagcctac ttacaagtat gatacgggct ctgacgactg   1620

ggataccagt gagaagtgcc gtgctcctgc ctggtgtgat cggattctct ggaaagggaa   1680

gaacatcact cagctgagtt accagagcca catggccctg aagaccagtg accacaagcc   1740

tgtcagctca gtgtttgaca tcggggtgag ggtcgtaaat gacgagcttt accggaagac   1800

actggaggaa attgttcgct ccctggataa gatggaaaat gccaacattc cttctgtgtc   1860

cctgtccaag cgagagttct gttttcagaa tgtgaagtac atgcaattga aagtagaatc   1920

ctttacaatt cataatggac aagtaccctg tcattttgaa ttcatcaaca agcctgatga   1980

agagtcttac tgtaagcagt ggctgaatgc caaccccagc agaggcttcc tcctgccaga   2040

ttctgatgtt gagattgact tggagctctt cgtaaataag atgacagcta caaagctcaa   2100

ctcgggtgaa gacaaaattg aggacattct ggttctgcac ttggacaggg gaaaggatta   2160

ctttttgtct gtgtctggga actacctgcc cagctgtttt gggtctccca ttcatacact   2220

gtgttacatg agagagccaa tcttggacct accacttgaa accattagtg agctgactct   2280

gatgccagta tggactggag atgatgggag ccagttggat agccccatgg aaatccccaa   2340

agagctctgg atgatggttg attacctgta ccgaaatgct gtccagcagg aagatctgtt   2400

tcagcaacca ggcctgaggt cagaatttga acatatcagg gactgcttgg atactggaat   2460

gattgataac ctctctgcca gcaatcattc tgtagccgaa gccctgctgc ttttcctgga   2520

gagccttcca gagcctgtca tctgttacag cacctaccat aactgcttgg agtgttctgg   2580

caactacaca gcaagcaaac aggtcatttc tactctcccc atattccaca aaaatgtctt   2640

ccactacttg atggcgtttt tgcgagaact gctgaaaaat tcagcaaaaa atcatttgga   2700

tgagaatatt ctagctagca tatttggcag cttattgctt cgaaacccag ctggtcacca   2760

aaagcttgat atgacagaga agaagaaggc tcaagaattt attcaccagt tcctctgcaa   2820

cccactctga gcctctctct cctcctattt tacttgaggc tgccaattac cagccccacc   2880

tgtttcagct caagagatgc cttaagataa ttatgtgagg ccacttggta gcaagaatgg   2940

cagctatttc ctgagcctag taccccaatt aagcccacca ttggttagca cactcagcgc   3000

tgtgagtcgt gaagacacgg gagaaaatcc accataataa aactgacatt caattttc     3058


<210>  6084
<211>  913
<212>  PRT
<213>  Homosapiens

<400>  6084

Met Asp Gln Ser Val Ala Ile Gln Glu Thr Leu Ala Glu Gly Glu Tyr 
1               5                   10                  15      


Cys Val Ile Ala Val Gln Gly Val Leu Cys Glu Gly Asp Ser Arg Gln 
            20                  25                  30          


Ser Arg Leu Leu Gly Leu Val Arg Tyr Arg Leu Glu His Gly Gly Gln 
        35                  40                  45              


Glu His Ala Leu Phe Leu Tyr Thr His Arg Arg Met Ala Ile Thr Gly 
    50                  55                  60                  


Asp Asp Val Ser Leu Asp Gln Ile Val Pro Val Ser Arg Asp Phe Thr 
65                  70                  75                  80  


Leu Glu Glu Val Ser Pro Asp Gly Glu Leu Tyr Ile Leu Gly Ser Asp 
                85                  90                  95      


Val Thr Val Gln Leu Asp Thr Ala Glu Leu Ser Leu Val Phe Gln Leu 
            100                 105                 110         


Pro Phe Gly Ser Gln Thr Arg Met Phe Leu His Glu Val Ala Arg Ala 
        115                 120                 125             


Cys Pro Gly Phe Asp Ser Ala Thr Arg Asp Pro Glu Phe Leu Trp Leu 
    130                 135                 140                 


Ser Arg Tyr Arg Cys Ala Glu Leu Glu Leu Glu Met Pro Thr Pro Arg 
145                 150                 155                 160 


Gly Cys Asn Ser Ala Leu Val Thr Trp Pro Gly Tyr Ala Thr Ile Gly 
                165                 170                 175     


Gly Gly Gly Ser Asn Phe Asp Gly Leu Arg Pro Asn Gly Lys Gly Val 
            180                 185                 190         


Pro Met Asp Gln Ser Ser Arg Gly Gln Asp Lys Pro Glu Ser Leu Gln 
        195                 200                 205             


Pro Arg Gln Asn Lys Ser Lys Ser Glu Ile Thr Asp Met Val Arg Ser 
    210                 215                 220                 


Ser Thr Ile Thr Val Ser Asp Lys Ala His Ile Leu Ser Met Gln Lys 
225                 230                 235                 240 


Phe Gly Leu Arg Asp Thr Ile Val Lys Ser His Leu Leu Gln Lys Glu 
                245                 250                 255     


Glu Asp Tyr Thr Tyr Ile Gln Asn Phe Arg Phe Phe Ala Gly Thr Tyr 
            260                 265                 270         


Asn Val Asn Gly Gln Ser Pro Lys Glu Cys Leu Arg Leu Trp Leu Ser 
        275                 280                 285             


Asn Gly Ile Gln Ala Pro Asp Val Tyr Cys Val Gly Phe Gln Glu Leu 
    290                 295                 300                 


Asp Leu Ser Lys Glu Ala Phe Phe Phe His Asp Thr Pro Lys Glu Glu 
305                 310                 315                 320 


Glu Trp Phe Lys Ala Val Ser Glu Gly Leu His Pro Asp Ala Lys Tyr 
                325                 330                 335     


Ala Lys Val Lys Leu Ile Arg Leu Val Gly Ile Met Leu Leu Leu Tyr 
            340                 345                 350         


Val Lys Gln Glu His Ala Ala Tyr Ile Ser Glu Val Glu Ala Glu Thr 
        355                 360                 365             


Val Gly Thr Gly Ile Met Gly Arg Met Gly Asn Lys Gly Gly Val Ala 
    370                 375                 380                 


Ile Arg Phe Gln Phe His Asn Thr Ser Ile Cys Val Val Asn Ser His 
385                 390                 395                 400 


Leu Ala Ala His Ile Glu Glu Tyr Glu Arg Arg Asn Gln Asp Tyr Lys 
                405                 410                 415     


Asp Ile Cys Ser Arg Met Gln Phe Cys Gln Pro Asp Pro Ser Leu Pro 
            420                 425                 430         


Pro Leu Thr Ile Ser Asn His Asp Val Ile Leu Trp Leu Gly Asp Leu 
        435                 440                 445             


Asn Tyr Arg Ile Glu Glu Leu Asp Val Glu Lys Val Lys Lys Leu Ile 
    450                 455                 460                 


Glu Glu Lys Asp Phe Gln Met Leu Tyr Ala Tyr Asp Gln Leu Lys Ile 
465                 470                 475                 480 


Gln Val Ala Ala Lys Thr Val Phe Glu Gly Phe Thr Glu Gly Glu Leu 
                485                 490                 495     


Thr Phe Gln Pro Thr Tyr Lys Tyr Asp Thr Gly Ser Asp Asp Trp Asp 
            500                 505                 510         


Thr Ser Glu Lys Cys Arg Ala Pro Ala Trp Cys Asp Arg Ile Leu Trp 
        515                 520                 525             


Lys Gly Lys Asn Ile Thr Gln Leu Ser Tyr Gln Ser His Met Ala Leu 
    530                 535                 540                 


Lys Thr Ser Asp His Lys Pro Val Ser Ser Val Phe Asp Ile Gly Val 
545                 550                 555                 560 


Arg Val Val Asn Asp Glu Leu Tyr Arg Lys Thr Leu Glu Glu Ile Val 
                565                 570                 575     


Arg Ser Leu Asp Lys Met Glu Asn Ala Asn Ile Pro Ser Val Ser Leu 
            580                 585                 590         


Ser Lys Arg Glu Phe Cys Phe Gln Asn Val Lys Tyr Met Gln Leu Lys 
        595                 600                 605             


Val Glu Ser Phe Thr Ile His Asn Gly Gln Val Pro Cys His Phe Glu 
    610                 615                 620                 


Phe Ile Asn Lys Pro Asp Glu Glu Ser Tyr Cys Lys Gln Trp Leu Asn 
625                 630                 635                 640 


Ala Asn Pro Ser Arg Gly Phe Leu Leu Pro Asp Ser Asp Val Glu Ile 
                645                 650                 655     


Asp Leu Glu Leu Phe Val Asn Lys Met Thr Ala Thr Lys Leu Asn Ser 
            660                 665                 670         


Gly Glu Asp Lys Ile Glu Asp Ile Leu Val Leu His Leu Asp Arg Gly 
        675                 680                 685             


Lys Asp Tyr Phe Leu Ser Val Ser Gly Asn Tyr Leu Pro Ser Cys Phe 
    690                 695                 700                 


Gly Ser Pro Ile His Thr Leu Cys Tyr Met Arg Glu Pro Ile Leu Asp 
705                 710                 715                 720 


Leu Pro Leu Glu Thr Ile Ser Glu Leu Thr Leu Met Pro Val Trp Thr 
                725                 730                 735     


Gly Asp Asp Gly Ser Gln Leu Asp Ser Pro Met Glu Ile Pro Lys Glu 
            740                 745                 750         


Leu Trp Met Met Val Asp Tyr Leu Tyr Arg Asn Ala Val Gln Gln Glu 
        755                 760                 765             


Asp Leu Phe Gln Gln Pro Gly Leu Arg Ser Glu Phe Glu His Ile Arg 
    770                 775                 780                 


Asp Cys Leu Asp Thr Gly Met Ile Asp Asn Leu Ser Ala Ser Asn His 
785                 790                 795                 800 


Ser Val Ala Glu Ala Leu Leu Leu Phe Leu Glu Ser Leu Pro Glu Pro 
                805                 810                 815     


Val Ile Cys Tyr Ser Thr Tyr His Asn Cys Leu Glu Cys Ser Gly Asn 
            820                 825                 830         


Tyr Thr Ala Ser Lys Gln Val Ile Ser Thr Leu Pro Ile Phe His Lys 
        835                 840                 845             


Asn Val Phe His Tyr Leu Met Ala Phe Leu Arg Glu Leu Leu Lys Asn 
    850                 855                 860                 


Ser Ala Lys Asn His Leu Asp Glu Asn Ile Leu Ala Ser Ile Phe Gly 
865                 870                 875                 880 


Ser Leu Leu Leu Arg Asn Pro Ala Gly His Gln Lys Leu Asp Met Thr 
                885                 890                 895     


Glu Lys Lys Lys Ala Gln Glu Phe Ile His Gln Phe Leu Cys Asn Pro 
            900                 905                 910         


Leu 
    


<210>  6085
<211>  747
<212>  DNA
<213>  Homosapiens

<400>  6085
tgaaataaac agccctgttg ctcacacaaa gcctgttggt ggtctcttca caaggatgcg     60

tgtgacattt ggtgccaaaa cccaggacag gaggactcct tcaggagacc agtcccctgt    120

cttcgccctc actccgtgac ctcaggtcct cagaccaacc agcccaagga acatctcacc    180

aacttcaaat tgggacccca ctggaaatca gactgtccaa ctcacccagc agccactccc    240

agagcccctg gaactctggc ccaaggctct ctgactgact ccttcccaga tcgtctcagc    300

ttagcggctg aagactgaca ctgcccgatc gcctcggaag cctacaggac catcacagat    360

gctctggata actcttacag tggagggtta agacccaaac tggttcaatt ggcatctgac    420

gccctttgca aatggctcta ctctccttca tcaatccatc acccaaagac agcctgatct    480

aaaaggatag attcttcaca catgccatcc gcactcctgc cttcatatga agttactcct    540

actttttggc cacctctcct tcgaagccca gcctcaactc ccacctcctc cttcatgaag    600

ccctccccag ccacataagt tctcagtagt catttctctg aattttgagt gtcttcctgt    660

ctatataatg tgtctggcac tttaagaaac attagactgt tttggaaaat gccttgggct    720

ttggaataaa atagagctgg tgatgtt                                        747


<210>  6086
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  6086

Met Pro Ser Ala Leu Leu Pro Ser Tyr Glu Val Thr Pro Thr Phe Trp 
1               5                   10                  15      


Pro Pro Leu Leu Arg Ser Pro Ala Ser Thr Pro Thr Ser Ser Phe Met 
            20                  25                  30          


Lys Pro Ser Pro Ala Thr 
        35              


<210>  6087
<211>  3806
<212>  DNA
<213>  Homosapiens

<400>  6087
agggtgtgtg cgctcagcag gggccagcat ggaccagtct gtggcaatcc aggagacgct     60

ggctgagggg gaatactgcg tcatcgcggt gcaaggtgtg ctgtgtgagg gggacagccg    120

gcagagccgc ctcctgggac tcgtgcgcta ccgcctggag cacggcggcc aggaacacgc    180

tctcttcctc tatacgcacc ggaggatggc cattaccggg gacgatgtct ctctggacca    240

gatagtgcca gtctcgcggg attttacgct ggaagaagtg tccccagatg gtgaactcta    300

catccttggc tcagatgtga ccgtccagct ggacacagca gagcttagcc tcgtattcca    360

actgcccttt ggttcacaaa ccaggatgtt cctccacgaa gttgccaggg cctgtccagg    420

cttcgattct gcgacccggg atcctgaatt cctgtggctg tctcggtata ggtgcgcaga    480

gctggagctg gagatgccaa cgccgcgcgg ttgtaactcg gccctagtta cctggccagg    540

gtacgcgaca attggcggag gcaggtatcc gtcccggaag aaacggtggg gattggagga    600

ggcccggcca cagggggcgg gctccgttct gttttggggc ggagcgatgg agaagacagg    660

ctttcgattg atggagcggg cacacggggg cgggttcgtc tgggggcgga gcgcgcggga    720

cgggcggcgg gatgaggagc ttgaggaagc aggcagggaa atgtctgccg ccgccggctc    780

tcgggagcgc aacactgcag gttcggcggg cggcgggaag ctgggctggg gagctgggcc    840

gggggcggcg gtgcgcccgg ccctcgggtg ggcagggtcg gcggtttggc cagtggacgc    900

tcggggcgaa gaccaaagtc ctggtggccc tctggaggct gggacactgg ggcagaagtt    960

ctgtgatgtt cttcttaggc gtgcgtgacg agggtaggcg ggtgggaatg gggtacttgg   1020

gaatccggag gctggggttt tagtaaagct ccgttccgaa ctcgctgtgt gacctcgggc   1080

cactcgctgc ccctctctgg gcctgttgct ccatctgagc ttgctcttca atcctgatct   1140

tccgagtttg tcgcgtgggg cgggtggggg agtggtgccc tgcctacgat agagtcttcc   1200

tttgggtgag gtatggtatg tgttggggct ctgtcagttc tcagcccctg tgatgatagc   1260

gcagtgtaca gggctggagt cttggggagc cctgtctact ctgggactag aggccaggat   1320

gaagttacag gttataaaag gactaggttt tttcccaccc agcagttggt ggataatggg   1380

gagcacagaa ggccagttgc tgagcaggag cttgtcgttt ggagatggga ggctcagggc   1440

tgaaatttgg gtgagtccgt gctctgggag gacctgcaga cctgtctttt tttgtccagc   1500

tccagggttt tctgcaaggg cccctggtgc ttttttcccc tgggtgtgtc cgtgaggctc   1560

catttatgtg tgagctttgg catgacccct agtacctatt tgtgacagtc atttgccagc   1620

aatgaagagc ctgtcaagta gctgtgtaaa gtgtgggcca gccctccact tgctcttaca   1680

aggcttggaa actatgaggg gcagggagga gtggcatgtt gcacaagagt ttgtaaactg   1740

agaggaaacg aggtgagcag aggacttcct cggtgcttgt ttctccttca ttgcagccat   1800

cacaaggtgc gatcgaagcg cctgatggtg ctgatagttt gcatcttcct tgggcttatc   1860

tcagagttca ctatcactag agtttccatg acattctggg ctatggtgct gggacgggtg   1920

agagtttaag agcacctcat ctccttgccc cttcacaaga gactgccaga atccagacaa   1980

ttggcggagg acaaggccaa tggcagcaga aagaggtggg tgctgtgttc tcagccagta   2040

caccagagcc aggccatgca ggcacttcat tcccttagtc ttctatgaca agtcaggcca   2100

gctagctctg aagccagtta gctgccccga ctgagaaatg tgcagggatc tcaatctttc   2160

atttcctttc aaaaaacaga gactagccat atgctggtga ggaattattg ttacggtttc   2220

ggttttattt ttattttaaa ataatttgaa agctgaacat ggtggcgcgt acctgtagtc   2280

ccagccactt gagaggctga ggtggaaggc ttgagcccag gagtttgagg gtgatgtgca   2340

ctatgattga tcctgtgaat tagttgctgc actccagcct aggcaacata gtgagactgt   2400

ctctaaaata aataaataaa tagttttaaa aattttgtca gccaggcgtg gtgactcatg   2460

cctgtaatcc cagcactgtg ggaagctgag gcgggcggat cacctgaggt caggagttcg   2520

agaccagcct ggccaacatg gcgaaactcc gtcactacta aaaatacaaa aattagatgg   2580

gcgtggtggc aggtgcctgt aatcccatgt actctggagg ctgaggtagg agaattgctt   2640

gaacccagga ggcagaggtt gcagtgagcc gagatcgtgc cattgcattc cagcctggga   2700

gacggagcaa gactccatct cgaaaaaaaa aaaaattttt ctcttaaaat acctacagta   2760

agtggggtga cactattaat tgctaagttg ctcctgctaa aattggtaag aaatggtatc   2820

aagcccctca gttctatttg ggtcatctgt ttccagagtt attatggcct cagaggagag   2880

ttacatcttc tataacaggt aggaagaacc ctttgggctg cctttggatg tcgatacagg   2940

ccccaaggga aacagagtag tagattgttt tttcctatat gcatatgatc aaaataccca   3000

ctttttgata gcctagagaa cccaaagcaa acagttgctt aaaaatgctg tttctggctg   3060

ggcacgatga ctcatgcctt taatcccaac actttggaag gctgaggcgg gcggatcatg   3120

aggtcaggag ttcgagacca gcctggccaa catggcgaaa ccctgtctct actaaaaata   3180

caaaaattag atgggtgtag tggcacatgg ctataatccc aggtacttgg gaagctgagg   3240

taggagaatc gcttgaaccc aggaggcaga ggttgcagtg cgctgagatc gtgccactgc   3300

actccagcct gggagacaga gcgagactcc atctcaaaaa aaaaaaaatt tttttttatc   3360

ttatcgtaat acctacagta agtgactggg tgacactgtt aattgctaag ttgctgctgc   3420

taaaattggt aagaaatggt atcaagctct ccagttctgt ttgggtcatc tctgtttcca   3480

gagttgttct ggcctcagag gagagttaca tcttctataa caggtgggaa gaaccctttg   3540

ggctgcctct ggatgtcgat acaggcccca agggaaacgg agtagtagat ttgttttttc   3600

ctatatgcat atgatcaaaa tacccactac ttgatagcct agagaaacca aggcaaatgg   3660

ttgcttaaaa atgctgtttt tggctgggcg cggtggctca tgcctgtaat cccagcactt   3720

tgggaggctg aggcaggcgg atcacaaggt caggagatca agaccatcct ggctaacacg   3780

gtgaaacccc atctctacta aaaata                                        3806


<210>  6088
<211>  319
<212>  PRT
<213>  Homosapiens

<400>  6088

Met Asp Gln Ser Val Ala Ile Gln Glu Thr Leu Ala Glu Gly Glu Tyr 
1               5                   10                  15      


Cys Val Ile Ala Val Gln Gly Val Leu Cys Glu Gly Asp Ser Arg Gln 
            20                  25                  30          


Ser Arg Leu Leu Gly Leu Val Arg Tyr Arg Leu Glu His Gly Gly Gln 
        35                  40                  45              


Glu His Ala Leu Phe Leu Tyr Thr His Arg Arg Met Ala Ile Thr Gly 
    50                  55                  60                  


Asp Asp Val Ser Leu Asp Gln Ile Val Pro Val Ser Arg Asp Phe Thr 
65                  70                  75                  80  


Leu Glu Glu Val Ser Pro Asp Gly Glu Leu Tyr Ile Leu Gly Ser Asp 
                85                  90                  95      


Val Thr Val Gln Leu Asp Thr Ala Glu Leu Ser Leu Val Phe Gln Leu 
            100                 105                 110         


Pro Phe Gly Ser Gln Thr Arg Met Phe Leu His Glu Val Ala Arg Ala 
        115                 120                 125             


Cys Pro Gly Phe Asp Ser Ala Thr Arg Asp Pro Glu Phe Leu Trp Leu 
    130                 135                 140                 


Ser Arg Tyr Arg Cys Ala Glu Leu Glu Leu Glu Met Pro Thr Pro Arg 
145                 150                 155                 160 


Gly Cys Asn Ser Ala Leu Val Thr Trp Pro Gly Tyr Ala Thr Ile Gly 
                165                 170                 175     


Gly Gly Arg Tyr Pro Ser Arg Lys Lys Arg Trp Gly Leu Glu Glu Ala 
            180                 185                 190         


Arg Pro Gln Gly Ala Gly Ser Val Leu Phe Trp Gly Gly Ala Met Glu 
        195                 200                 205             


Lys Thr Gly Phe Arg Leu Met Glu Arg Ala His Gly Gly Gly Phe Val 
    210                 215                 220                 


Trp Gly Arg Ser Ala Arg Asp Gly Arg Arg Asp Glu Glu Leu Glu Glu 
225                 230                 235                 240 


Ala Gly Arg Glu Met Ser Ala Ala Ala Gly Ser Arg Glu Arg Asn Thr 
                245                 250                 255     


Ala Gly Ser Ala Gly Gly Gly Lys Leu Gly Trp Gly Ala Gly Pro Gly 
            260                 265                 270         


Ala Ala Val Arg Pro Ala Leu Gly Trp Ala Gly Ser Ala Val Trp Pro 
        275                 280                 285             


Val Asp Ala Arg Gly Glu Asp Gln Ser Pro Gly Gly Pro Leu Glu Ala 
    290                 295                 300                 


Gly Thr Leu Gly Gln Lys Phe Cys Asp Val Leu Leu Arg Arg Ala 
305                 310                 315                 


<210>  6089
<211>  4008
<212>  DNA
<213>  Homosapiens

<400>  6089
gggctgttgg gaaatgtagt cactgtcccg gaacctgggg cagcggagtc ccgtgcgccc     60

tgtggtgaca gctcaggagg gtgtgtgcgc tcagcagggg ccagcatgga ccagtctgtg    120

gcaatccagg agacgctggc tgagggggaa tactgcgtca tcgcggtgca aggtgtgctg    180

tgtgaggggg acagccggca gagccgcctc ctgggactcg tgcgctaccg cctggagcac    240

ggcggccagg aacacgctct cttcctctat acgcaccgga ggatggccat taccggggac    300

gatgtctctc tggaccagat agtgccagtc tcgcgggatt ttacgctgga agaagtgtcc    360

ccagatggtg aactctacat ccttggctca gatgtgaccg tccagctgga cacagcagag    420

cttagcctcg tattccaact gccctttggt tcacaaacca ggatgttcct ccacgaagtt    480

gccagggcct gtccaggctt cgattctgcg acccgggatc ctgaattcct gtggctgtct    540

cggtataggt gcgcagagct ggagctggag atgccaacgc cgcgcggttg taactcggcc    600

ctagttacct ggccagggta cgcgacaatt ggcggaggca ggtatccgtc ccggaagaaa    660

cggtggggat tggaggaggc ccggccacag ggggcgggct ccgttctgtt ttggggcgga    720

gcgatggaga agacaggctt tcgattgatg gagcgggcac acgggggcgg gttcgtctgg    780

gggcggagcg cgcgggacgg gcggcgggat gaggagcttg aggaagcagg cagggaaatg    840

tctgccgccg ccggctctcg ggagcgcaac actgcaggtt cggcgggcgg cgggaagctg    900

ggctggggag ctgggccggg ggcggcggtg cgcccggccc tcgggtgggc agggtcggcg    960

gtttggccag tggacgctcg gggcgaagac caaagtcctg gtggccctct ggaggctggg   1020

acactggggc agaagttctg tgatgttctt cttaggcgtg cgtgacgagg gtaggcgggt   1080

gggaatgggg tacttgggaa tccggaggct ggggttttag taaagctccg ttccgaactc   1140

gctgtgtgac ctcgggccac tcgctgcccc tctctgggcc tgttgctcca tctgagcttg   1200

ctcttcaatc ctgatcttcc gagtttgtcg cgtggggcgg gtgggggagt ggtgccctgc   1260

ctacgataga gtcttccttt gggtgaggta tggtatgtgt tggggctctg tcagttctca   1320

gcccctgtga tgatagcgca gtgtacaggg ctggagtctt ggggagccct gtctactctg   1380

ggactagagg ccaggatgaa gttacaggtt ataaaaggac taggtttttt cccacccagc   1440

agttggtgga taatggggag cacagaaggc cagttgctga gcaggagctt gtcgtttgga   1500

gatgggaggc tcagggctga aatttgggtg agtccgtgct ctgggaggac ctgcagacct   1560

gtcttttttt gtccagctcc agggttttct gcaagggccc ctggtgcttt tttcccctgg   1620

gtgtgtccgt gaggctccat ttatgtgtga gctttggcat gacccctagt acctatttgt   1680

gacagtcatt tgccagcaat gaagagcctg tcaagtagct gtgtaaagtg tgggccagcc   1740

ctccacttgc tcttacaagg cttggaaact atgaggggca gggaggagtg gcatgttgca   1800

caagagtttg taaactgaga ggaaacgagg tgagcagagg acttcctcgg tgcttgtttc   1860

tccttcattg cagccatcac aaggtgcgat cgaagcgcct gatggtgctg atagtttgca   1920

tcttccttgg gcttatctca gagttcacta tcactagagt ttccatgaca ttctgggcta   1980

tggtgctggg acgggtgaga gtttaagagc acctcatctc cttgcccctt cacaagagac   2040

tgccagaatc cagacaattg gcggaggaca aggccaatgg cagcagaaag aggtgggtgc   2100

tgtgttctca gccagtacac cagagccagg ccatgcaggc acttcattcc cttagtcttc   2160

tatgacaagt caggccagct agctctgaag ccagttagct gccccgactg agaaatgtgc   2220

agggatctca atctttcatt tcctttcaaa aaacagagac tagccatatg ctggtgagga   2280

attattgtta cggtttcggt tttattttta ttttaaaata atttgaaagc tgaacatggt   2340

ggcgcgtacc tgtagtccca gccacttgag aggctgaggt ggaaggcttg agcccaggag   2400

tttgagggtg atgtgcacta tgattgatcc tgtgaattag ttgctgcact ccagcctagg   2460

caacatagtg agactgtctc taaaataaat aaataaatag ttttaaaaat tttgtcagcc   2520

aggcgtggtg actcatgcct gtaatcccag cactgtggga agctgaggcg ggcggatcac   2580

ctgaggtcag gagttcgaga ccagcctggc caacatggcg aaactccgtc actactaaaa   2640

atacaaaaat tagatgggcg tggtggcagg tgcctgtaat cccatgtact ctggaggctg   2700

aggtaggaga attgcttgaa cccaggaggc agaggttgca gtgagccgag atcgtgccat   2760

tgcattccag cctgggagac ggagcaagac tccatctcga aaaaaaaaaa aatttttctc   2820

ttaaaatacc tacagtaagt ggggtgacac tattaattgc taagttgctc ctgctaaaat   2880

tggtaagaaa tggtatcaag cccctcagtt ctatttgggt catctgtttc cagagttatt   2940

atggcctcag aggagagtta catcttctat aacaggtagg aagaaccctt tgggctgcct   3000

ttggatgtcg atacaggccc caagggaaac agagtagtag attgtttttt cctatatgca   3060

tatgatcaaa atacccactt tttgatagcc tagagaaccc aaagcaaaca gttgcttaaa   3120

aatgctgttt ctggctgggc acgatgactc atgcctttaa tcccaacact ttggaaggct   3180

gaggcgggcg gatcatgagg tcaggagttc gagaccagcc tggccaacat ggcgaaaccc   3240

tgtctctact aaaaatacaa aaattagatg ggtgtagtgg cacatggcta taatcccagg   3300

tacttgggaa gctgaggtag gagaatcgct tgaacccagg aggcagaggt tgcagtgcgc   3360

tgagatcgtg ccactgcact ccagcctggg agacagagcg agactccatc tcaaaaaaaa   3420

aaaaattttt ttttatctta tcgtaatacc tacagtaagt gactgggtga cactgttaat   3480

tgctaagttg ctgctgctaa aattggtaag aaatggtatc aagctctcca gttctgtttg   3540

ggtcatctct gtttccagag ttgttctggc ctcagaggag agttacatct tctataacag   3600

gtgggaagaa ccctttgggc tgcctctgga tgtcgataca ggccccaagg gaaacggagt   3660

agtagatttg ttttttccta tatgcatatg atcaaaatac ccactacttg atagcctaga   3720

gaaaccaagg caaatggttg cttaaaaatg ctgtttttgg ctgggcgcgg tggctcatgc   3780

ctaatcctag cactttggga ggccgaggtg ggcggatcac aagatcagga gttcaagacc   3840

aggctgggca acatgacgaa atcctgtctc tactaaaaat ataaaaatta ggccaggcac   3900

agtggcttat gcctgtaatc ccagcacttt gggaggctga ggcaggcgga tcacaaggtc   3960

aggagatcaa gaccatcctg gctaacacgg tgaaacccca tctctact                4008


<210>  6090
<211>  319
<212>  PRT
<213>  Homosapiens

<400>  6090

Met Asp Gln Ser Val Ala Ile Gln Glu Thr Leu Ala Glu Gly Glu Tyr 
1               5                   10                  15      


Cys Val Ile Ala Val Gln Gly Val Leu Cys Glu Gly Asp Ser Arg Gln 
            20                  25                  30          


Ser Arg Leu Leu Gly Leu Val Arg Tyr Arg Leu Glu His Gly Gly Gln 
        35                  40                  45              


Glu His Ala Leu Phe Leu Tyr Thr His Arg Arg Met Ala Ile Thr Gly 
    50                  55                  60                  


Asp Asp Val Ser Leu Asp Gln Ile Val Pro Val Ser Arg Asp Phe Thr 
65                  70                  75                  80  


Leu Glu Glu Val Ser Pro Asp Gly Glu Leu Tyr Ile Leu Gly Ser Asp 
                85                  90                  95      


Val Thr Val Gln Leu Asp Thr Ala Glu Leu Ser Leu Val Phe Gln Leu 
            100                 105                 110         


Pro Phe Gly Ser Gln Thr Arg Met Phe Leu His Glu Val Ala Arg Ala 
        115                 120                 125             


Cys Pro Gly Phe Asp Ser Ala Thr Arg Asp Pro Glu Phe Leu Trp Leu 
    130                 135                 140                 


Ser Arg Tyr Arg Cys Ala Glu Leu Glu Leu Glu Met Pro Thr Pro Arg 
145                 150                 155                 160 


Gly Cys Asn Ser Ala Leu Val Thr Trp Pro Gly Tyr Ala Thr Ile Gly 
                165                 170                 175     


Gly Gly Arg Tyr Pro Ser Arg Lys Lys Arg Trp Gly Leu Glu Glu Ala 
            180                 185                 190         


Arg Pro Gln Gly Ala Gly Ser Val Leu Phe Trp Gly Gly Ala Met Glu 
        195                 200                 205             


Lys Thr Gly Phe Arg Leu Met Glu Arg Ala His Gly Gly Gly Phe Val 
    210                 215                 220                 


Trp Gly Arg Ser Ala Arg Asp Gly Arg Arg Asp Glu Glu Leu Glu Glu 
225                 230                 235                 240 


Ala Gly Arg Glu Met Ser Ala Ala Ala Gly Ser Arg Glu Arg Asn Thr 
                245                 250                 255     


Ala Gly Ser Ala Gly Gly Gly Lys Leu Gly Trp Gly Ala Gly Pro Gly 
            260                 265                 270         


Ala Ala Val Arg Pro Ala Leu Gly Trp Ala Gly Ser Ala Val Trp Pro 
        275                 280                 285             


Val Asp Ala Arg Gly Glu Asp Gln Ser Pro Gly Gly Pro Leu Glu Ala 
    290                 295                 300                 


Gly Thr Leu Gly Gln Lys Phe Cys Asp Val Leu Leu Arg Arg Ala 
305                 310                 315                 


<210>  6091
<211>  1156
<212>  DNA
<213>  Homosapiens

<400>  6091
aggaagaata tgaagactca agtgggaatg ttgtgaataa gaagacatac gaggatctga     60

aaagacaagg actgctctag tgttcaggga tgtagctcag cttttgggct agcccaggct    120

tccctaagat ctgctttttc tatttctccc aaccaaatcc tcttaaagac cctttgctat    180

gtagtctcat ggtctagcat gcatcttgta gaaacaaggc atgctggcag attgcagggt    240

tgagatgtgt tttatctgtt ttatatttta aaagattctg ccagaaaata aaaccagacc    300

ttgttctaaa gcccagggtt atggaccaac tcagtgcttc aggtcttaac gcctccatac    360

ctcttcctca ccaactttac tagtagctga gatttaatgg gcacctatta tgctacatat    420

catgttaggt aaatctgacc tgacctcttt ccccaccctc ctttgttgct gcttccctga    480

atgagtatta ccccaggatg aggtctgcca tcagcttagt tagccattga tgcaaatact    540

agggaaagac taggaggatg agccagggtt gctactaggt aacatagtga gaccctgtct    600

cattaaaaaa aaaaaaaagg catggtggca cgcactgtag tcccagctac tcaggagact    660

gaggctagaa gatcctttga acctaggagt ttgagaccag cctgggcgat atagtgaggc    720

cccatctcaa aaaaaaaaaa aggggggggg gggggagttg ggctgtgttg gaatgggcct    780

gcagcccaac aaacaaggga actaggaccg acagtgactt caccagcttg ctaggtcaga    840

atgagagact ggtgggtctg tctacctgtt tcttctacaa gatccctatt tgactgtaaa    900

agtagctaat actcacatgt tctccaatcc caggtagcca tggtagagtt gggtagagtt    960

gagcagctgc cccaggatcc aaatgtggtg tctgaaatgg aaagaactaa ggcaaccagg   1020

aaggcactga tctgccttat aagcacagtc atctgaaagt caggcctgct gcaggacagg   1080

atcccccaga gaccccattt gcctctcaac actcagacct tcaactgttt tttaataaat   1140

ctacttttta aaaaaa                                                   1156


<210>  6092
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  6092

Met Val Glu Leu Gly Arg Val Glu Gln Leu Pro Gln Asp Pro Asn Val 
1               5                   10                  15      


Val Ser Glu Met Glu Arg Thr Lys Ala Thr Arg Lys Ala Leu Ile Cys 
            20                  25                  30          


Leu Ile Ser Thr Val Ile 
        35              


<210>  6093
<211>  1135
<212>  DNA
<213>  Homosapiens

<400>  6093
aggaagaata tgaagactca agtgggaatg ttgtgaataa gaagacatac gaggatctga     60

aaagacaagg actgctctag tgttcaggga tgtagctcag cttttgggct agcccaggct    120

tccctaagat ctgctttttc tatttctccc aaccaaatcc tcttaaagac cctttgctat    180

gtagtctcat ggtctagcat gcatcttgta gaaacaaggc atgctggcag attgcagggt    240

tgagatgtgt tttatctgtt ttatatttta aaagattctg ccagaaaata aaaccagacc    300

ttgttctaaa gcccagggtt atggaccaac tcagtgcttc aggtcttaac gcctccatac    360

ctcttcctca ccaactttac tagtagctga gatttaatgg gcacctatta tgctacatat    420

catgactaag tgtcgcacca aggtttgcct tttgtatttg cataaagaaa ggagttggag    480

ctgggtgcag tggcttgtgc ctgtagtccc agctacttgg gaggctgagg caggagggtt    540

gcttgagact agcctaggta acatagtgag accctgtctc attaaaaaaa aaaaaaaggc    600

atggtggcac gcactgtagt cccagctact caggagactg aggctagaag atcctttgaa    660

cctaggagtt tgagaccagc ctgggcgata tagtgaggcc ccatctcaaa aaaaaaaaaa    720

gggggggggg ggggagttgg gctgtgttgg aatgggcctg cagcccaaca aacaagggaa    780

ctaggaccga cagtgacttc accagcttgc taggtcagaa tgagagactg gtgggtctgt    840

ctacctgttt cttctacaag atccctattt gactgtaaaa gtagctaata ctcacatgtt    900

ctccaatccc aggtagccat ggtagagttg ggtagagttg agcagctgcc ccaggatcca    960

aatgtggtgt ctgaaatgga aagaactaag gcaaccagga aggcactgat ctgccttata   1020

agcacagtca tctgaaagtc aggcctgctg caggacagga tcccccagag accccatttg   1080

cctctcaaca ctcagacctt caactgtttt ttaataaatc tactttttaa aaaaa        1135


<210>  6094
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  6094

Met Leu His Ile Met Thr Lys Cys Arg Thr Lys Val Cys Leu Leu Tyr 
1               5                   10                  15      


Leu His Lys Glu Arg Ser Trp Ser Trp Val Gln Trp Leu Val Pro Val 
            20                  25                  30          


Val Pro Ala Thr Trp Glu Ala Glu Ala Gly Gly Leu Leu Glu Thr Ser 
        35                  40                  45              


Leu Gly Asn Ile Val Arg Pro Cys Leu Ile Lys Lys Lys Lys Lys Ala 
    50                  55                  60                  


Trp Trp His Ala Leu 
65                  


<210>  6095
<211>  1863
<212>  DNA
<213>  Homosapiens

<400>  6095
gggcgacaga gcgagagtcc gtctcaaaaa aaaagattca agttgttctt tccctggttt     60

gtatctgttt ttttcttgtg tatacttgtc tgatcactcc ttctgaagct acaatgattt    120

ttttggatgt ctttaccttt tctccttcat agagattgtt attgaactat tagaattttt    180

atattatgag ctttaagaaa gtaaagtcac tttccccatt attctcatag gttgttccac    240

attaacctcc ttcaagagta tcagtttctc tgttttcgga ggtctttggt tatatttgat    300

ccaactttta tagcaaagca agatcatgat gaattttgca gtggaaaggg ttttgtctat    360

aggtggtcca gaaccaaaac tctggtttgg ggtaggcaag aatctcaaag gcagagtctt    420

ctagggagca tcctaatggc agggagagag gattataaca ctggataccc aacagatgtt    480

cagtccatcc tgattgctgt tcatttctca tcctgcagtg tgggccaaac tgaaattgca    540

gaaggcttca gaacgatggc agcctgacac tgaggaagaa tatgaagact caagtgggaa    600

tgttgtgaat aagaagacat acgaggatct gaaaagacaa ggactgctct agtgttcagg    660

gatgtagctc agcttttggg ctagcccagg cttccctaag atctgctttt tctatttctc    720

ccaaccaaat cctcttaaag accctttgct atgtagtctc atggtctagc atgcatcttg    780

tagaaacaag gcatgctggc agattgcagg gttgagatgt gttttatctg ttttatattt    840

taaaagattc tgccagaaaa taaaaccaga ccttgttcta aagcccaggg ttatggacca    900

actcagtgct tcaggtctta acgcctccat acctcttcct caccaacttt actagtagct    960

gagatttaat gggcacctat tatgctacat atcatgttag gtaaatctga cctgacctct   1020

ttccccaccc tcctttgttg ctgcttccct gaatgagtat taccccagga tgaggtctgc   1080

catcagctta gttagccatt gatgcaaata ctagggaaag actaggagga tgagccaggg   1140

ttgctactaa ggactaagtg tcgcaccaag gtttgccttt tgtatttgca taaagaaagg   1200

agttggagct gggtgcagtg gcttgtgcct gtagtcccag ctacttggga ggctgaggca   1260

ggagggttgc ttgagactag cctaggtaac atagtgagac cctgtctcat taaaaaaaaa   1320

aaaaaggcat ggtggcacgc actgtagtcc cagctactca ggagactgag gctagaagat   1380

cctttgaacc taggagtttg agaccagcct gggcgatata gtgaggcccc atctcaaaaa   1440

aaaaaaaagg gggggggggg ggagttgggc tgtgttggaa tgggcctgca gcccaacaaa   1500

caagggaact aggaccgaca gtgacttcac cagcttgcta ggtcagaatg agagactggt   1560

gggtctgtct acctgtttct tctacaagat ccctatttga ctgtaaaagt agctaatact   1620

cacatgttct ccaatcccag gtagccatgg tagagttggg tagagttgag cagctgcccc   1680

aggatccaaa tgtggtgtct gaaatggaaa gaactaaggc aaccaggaag gcactgatct   1740

gccttataag cacagtcatc tgaaagtcag gcctgctgca ggacaggatc ccccagagac   1800

cccatttgcc tctcaacact cagaccttca actgtttttt aataaatcta ctttttaaaa   1860

aaa                                                                 1863


<210>  6096
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  6096

Met Ala Gly Arg Glu Asp Tyr Asn Thr Gly Tyr Pro Thr Asp Val Gln 
1               5                   10                  15      


Ser Ile Leu Ile Ala Val His Phe Ser Ser Cys Ser Val Gly Gln Thr 
            20                  25                  30          


Glu Ile Ala Glu Gly Phe Arg Thr Met Ala Ala 
        35                  40              


<210>  6097
<211>  1945
<212>  DNA
<213>  Homosapiens

<400>  6097
tttcctatgc cccctggagg catctgcgaa cctctcggca tcgctccacc acacctccca     60

ccagcaggtg gcactgttgc catctccata acatggactg gccttccttg tggtgctcct    120

gttttcttaa gtcccggggc acttccggca ctcgcggaac tttggtgcag cctgatgcgc    180

aacgtgggga ctcaggcgcg ctgggcggca ggagttgctt ccggccgtgt tggtggtctg    240

aattgagaag ccgcgactaa gggaagatgg agacaatact ggagcagcag cggcgctatc    300

atgaggagaa ggaacggctc atggacgtca tggctaaaga gatgctcacc aagaagtcca    360

cgctccggga ccagatcaat tctgatcacc gcactcgggc catgcaagat aggtatatgg    420

aggtcagtgg gaacctgagg gatttgtatg atgataagga tggaaactac acctaccgag    480

ggcccaaagc cttccagcga cactttgctg aatggcgtca tgctcatggc atgaggtgtt    540

tgggcatccc aaacactgct cactttgcta atgtgacaca gattgaagat gctgtctcct    600

tgtgggccaa actgaaattg cagaaggctt cagaacgatg gcagcctgac actgaggaag    660

aatatgaaga ctcaagtggg aatgttgtga ataagaagac atacgaggat ctgaaaagac    720

aaggactgct ctagtgttca gggatgtagc tcagcttttg ggctagccca ggcttcccta    780

agatctgctt tttctatttc tcccaaccaa atcctcttaa agaccctttg ctatgtagtc    840

tcatggtcta gcatgcatct tgtagaaaca aggcatgctg gcagattgca gggttgagat    900

gtgttttatc tgttttatat tttaaaagat tctgccagaa aataaaacca gaccttgttc    960

taaagcccag ggttatggac caactcagtg cttcaggtct taacgcctcc atacctcttc   1020

ctcaccaact ttactagtag ctgagattta atgggcacct attatgctac atatcatgtt   1080

aggtaaatct gacctgacct ctttccccac cctcctttgt tgctgcttcc ctgaatgagt   1140

attaccccag gatgaggtct gccatcagct tagttagcca ttgatgcaaa tactagggaa   1200

agactaggag gatgagccag ggttgctact aaggactaag tgtcgcacca aggtttgcct   1260

tttgtatttg cataaagaaa ggagttggag ctgggtgcag tggcttgtgc ctgtagtccc   1320

agctacttgg gaggctgagg caggagggtt gcttgagact agcctaggta acatagtgag   1380

accctgtctc attaaaaaaa aaaaaaaggc atggtggcac gcactgtagt cccagctact   1440

caggagactg aggctagaag atcctttgaa cctaggagtt tgagaccagc ctgggcgata   1500

tagtgaggcc ccatctcaaa aaaaaaaaaa gggggggggg ggggagttgg gctgtgttgg   1560

aatgggcctg cagcccaaca aacaagggaa ctaggaccga cagtgacttc accagcttgc   1620

taggtcagaa tgagagactg gtgggtctgt ctacctgttt cttctacaag atccctattt   1680

gactgtaaaa gtagctaata ctcacatgtt ctccaatccc aggtagccat ggtagagttg   1740

ggtagagttg agcagctgcc ccaggatcca aatgtggtgt ctgaaatgga aagaactaag   1800

gcaaccagga aggcactgat ctgccttata agcacagtca tctgaaagtc aggcctgctg   1860

caggacagga tcccccagag accccatttg cctctcaaca ctcagacctt caactgtttt   1920

ttaataaatc tactttttaa aaaaa                                         1945


<210>  6098
<211>  155
<212>  PRT
<213>  Homosapiens

<400>  6098

Met Glu Thr Ile Leu Glu Gln Gln Arg Arg Tyr His Glu Glu Lys Glu 
1               5                   10                  15      


Arg Leu Met Asp Val Met Ala Lys Glu Met Leu Thr Lys Lys Ser Thr 
            20                  25                  30          


Leu Arg Asp Gln Ile Asn Ser Asp His Arg Thr Arg Ala Met Gln Asp 
        35                  40                  45              


Arg Tyr Met Glu Val Ser Gly Asn Leu Arg Asp Leu Tyr Asp Asp Lys 
    50                  55                  60                  


Asp Gly Asn Tyr Thr Tyr Arg Gly Pro Lys Ala Phe Gln Arg His Phe 
65                  70                  75                  80  


Ala Glu Trp Arg His Ala His Gly Met Arg Cys Leu Gly Ile Pro Asn 
                85                  90                  95      


Thr Ala His Phe Ala Asn Val Thr Gln Ile Glu Asp Ala Val Ser Leu 
            100                 105                 110         


Trp Ala Lys Leu Lys Leu Gln Lys Ala Ser Glu Arg Trp Gln Pro Asp 
        115                 120                 125             


Thr Glu Glu Glu Tyr Glu Asp Ser Ser Gly Asn Val Val Asn Lys Lys 
    130                 135                 140                 


Thr Tyr Glu Asp Leu Lys Arg Gln Gly Leu Leu 
145                 150                 155 


<210>  6099
<211>  3673
<212>  DNA
<213>  Homosapiens

<400>  6099
gcagttttag tagagacggg gtttcaccgt gttagacagg atggtctcaa tctcctgatc     60

tcgttggatg cacagtattt tatttaacat attcgctgcc gatagacaag tcgtttctac    120

acgtgaattt cttttttttt tttttttttg agactgagtc tcattctgtc gcccaggctg    180

gagtgcagtg gcacgatctc agctgacggc aacctctgct tcccgggttc aagcgattct    240

cctgcctcag cctccggagt agctgggact acaggcgcct gccatcacgc ccggctaatt    300

tttgtttgtt tgtttttagt agagacgggg tttcaccatg ttagccagcc tggtcgtctc    360

gaacctctga cctcaagtga tccgcccgcc tcggcctccc aaagtgttgg gattacaggc    420

gtgagctacc gcgcccggcc tcacatgtga atttttttaa aaacaccacc agcaaaaccc    480

cactattccc attttcctga gaaagacgct gaggtccaga gaaagagaaa acgttctcat    540

aatttatgct gaaagctgcg tcctcaagtt ccggtttccc aactcccatc cgcactccaa    600

ctgctcgcgc agtccacaca ggatacctgc ccgccaagcc ggccccagca agccgcagga    660

agccgtccgc tgaacctcag gttcttgggt tttcctatgc cccctggagg catctgcgaa    720

cctctcggca tcgctccacc acacctccca ccagcaggtg gcactgttgc catctccata    780

acatggactg gccttccttg tggtgctcct gttttcttaa gtcccggggc acttccggca    840

ctcgcggaac tttggtgcag cctgatgcgc aacgtgggga ctcaggcgcg ctgggcggca    900

ggagttgctt ccggccgtgt tggtggtctg aattgagaag ccgcgactaa gggaagatgg    960

agacaatact ggagcagcag cggcgctatc atgaggagaa ggaacggctc atggacgtca   1020

tggctaaaga gatgctcacc aagaagtcca cgctccggga ccagatcaat tctgatcacc   1080

gcactcgggc catgcaagat aggtatatgg aggtcagtgg gaacctgagg gatttgtatg   1140

atgataagga tggattacga aaggaggagc tcaatgccat ttcaggaccc aatgagtttg   1200

ctgaattcta taatagactc aagcaaataa aggaattcca ccggaagcac ccaaatgaga   1260

tctgtgtgcc aatgtcagtg gaatttgagg aactcctgaa ggctcgagag aatccaagtg   1320

aagaggcaca aaacttggtg gagttcacag atgaagaggg atatggtcgt tatctcgatc   1380

tccatgactg ttacctcaag tacattaacc tgaaggcatc tgagaagctg gattatatca   1440

catacctgtc catctttgac caattatttg acattcctaa agaaaggaag aatgcagagt   1500

ataagagata cctagagatg ctgcttgagt accttcagga ttacacagat agagtgaagc   1560

ctctccaaga tcagaatgaa ctttttggga agattcaggc tgagtttgag aagaaatggg   1620

agaatgggac ctttcctgga tggccgaaag agacaagcag tgccctgacc catgctggag   1680

cccatcttga cctctctgca ttctcctcct gggaggagtt ggcttctctg ggtttggaca   1740

gattgaaatc tgctctctta gctttaggct tgaaatgtgg cgggacccta gaagagcgag   1800

cccagagact attcagtacc aaaggaaagt ccctggagtc acttgatacc tctttgtttg   1860

ccaaaaatcc caagtcaaag ggcaccaagc gagacactga aaggaacaaa gacattgctt   1920

ttctagaagc ccagatctat gaatatgtag agattctcgg ggaacagcga catctcactc   1980

atgaaaatgt acagcgcaag caagccagga caggagaaga gcgagaagaa gaggaagaag   2040

agcagatcag tgagagtgag agtgaagatg aagagaacga gatcatttac aaccccaaaa   2100

acctgccact tggctgggat ggcaaaccta ttccctactg gctgtataag cttcatggcc   2160

taaatatcaa ctacaactgt gagatttgtg gaaactacac ctaccgaggg cccaaagcct   2220

tccagcgaca ctttgctgaa tggcgtcatg ctcatggcat gaggtgtttg ggcatcccaa   2280

acactgctca ctttgctaat gtgacacaga ttgaagatgc tgtctccttg tgggccaaac   2340

tgaaattgca gaaggcttca gaacgatggc agcctgacac tgaggaagaa tatgaagact   2400

caagtgggaa tgttgtgaat aagaagacat acgaggatct gaaaagacaa ggactgctct   2460

agtgttcagg gatgtagctc agcttttggg ctagcccagg cttccctaag atctgctttt   2520

tctatttctc ccaaccaaat cctcttaaag accctttgct atgtagtctc atggtctagc   2580

atgcatcttg tagaaacaag gcatgctggc agattgcagg gttgagatgt gttttatctg   2640

ttttatattt taaaagattc tgccagaaaa taaaaccaga ccttgttcta aagcccaggg   2700

ttatggacca actcagtgct tcaggtctta acgcctccat acctcttcct caccaacttt   2760

actagtagct gagatttaat gggcacctat tatgctacat atcatgttag gtaaatctga   2820

cctgacctct ttccccaccc tcctttgttg ctgcttccct gaatgagtat taccccagga   2880

tgaggtctgc catcagctta gttagccatt gatgcaaata ctagggaaag actaggagga   2940

tgagccaggg ttgctactaa ggactaagtg tcgcaccaag gtttgccttt tgtatttgca   3000

taaagaaagg agttggagct gggtgcagtg gcttgtgcct gtagtcccag ctacttggga   3060

ggctgaggca ggagggttgc ttgagactag cctaggtaac atagtgagac cctgtctcat   3120

taaaaaaaaa aaaaaggcat ggtggcacgc actgtagtcc cagctactca ggagactgag   3180

gctagaagat cctttgaacc taggagtttg agaccagcct gggcgatata gtgaggcccc   3240

atctcaaaaa aaaaaaaagg gggggggggg ggagttgggc tgtgttggaa tgggcctgca   3300

gcccaacaaa caagggaact aggaccgaca gtgacttcac cagcttgcta ggtcagaatg   3360

agagactggt gggtctgtct acctgtttct tctacaagat ccctatttga ctgtaaaagt   3420

agctaatact cacatgttct ccaatcccag gtagccatgg tagagttggg tagagttgag   3480

cagctgcccc aggatccaaa tgtggtgtct gaaatggaaa gaactaaggc aaccaggaag   3540

gcactgatct gccttataag cacagtcatc tgaaagtcag gcctgctgca ggacaggatc   3600

ccccagagac cccatttgcc tctcaacact cagaccttca actgtttttt aataaatcta   3660

ctttttaaaa aaa                                                      3673


<210>  6100
<211>  501
<212>  PRT
<213>  Homosapiens

<400>  6100

Met Glu Thr Ile Leu Glu Gln Gln Arg Arg Tyr His Glu Glu Lys Glu 
1               5                   10                  15      


Arg Leu Met Asp Val Met Ala Lys Glu Met Leu Thr Lys Lys Ser Thr 
            20                  25                  30          


Leu Arg Asp Gln Ile Asn Ser Asp His Arg Thr Arg Ala Met Gln Asp 
        35                  40                  45              


Arg Tyr Met Glu Val Ser Gly Asn Leu Arg Asp Leu Tyr Asp Asp Lys 
    50                  55                  60                  


Asp Gly Leu Arg Lys Glu Glu Leu Asn Ala Ile Ser Gly Pro Asn Glu 
65                  70                  75                  80  


Phe Ala Glu Phe Tyr Asn Arg Leu Lys Gln Ile Lys Glu Phe His Arg 
                85                  90                  95      


Lys His Pro Asn Glu Ile Cys Val Pro Met Ser Val Glu Phe Glu Glu 
            100                 105                 110         


Leu Leu Lys Ala Arg Glu Asn Pro Ser Glu Glu Ala Gln Asn Leu Val 
        115                 120                 125             


Glu Phe Thr Asp Glu Glu Gly Tyr Gly Arg Tyr Leu Asp Leu His Asp 
    130                 135                 140                 


Cys Tyr Leu Lys Tyr Ile Asn Leu Lys Ala Ser Glu Lys Leu Asp Tyr 
145                 150                 155                 160 


Ile Thr Tyr Leu Ser Ile Phe Asp Gln Leu Phe Asp Ile Pro Lys Glu 
                165                 170                 175     


Arg Lys Asn Ala Glu Tyr Lys Arg Tyr Leu Glu Met Leu Leu Glu Tyr 
            180                 185                 190         


Leu Gln Asp Tyr Thr Asp Arg Val Lys Pro Leu Gln Asp Gln Asn Glu 
        195                 200                 205             


Leu Phe Gly Lys Ile Gln Ala Glu Phe Glu Lys Lys Trp Glu Asn Gly 
    210                 215                 220                 


Thr Phe Pro Gly Trp Pro Lys Glu Thr Ser Ser Ala Leu Thr His Ala 
225                 230                 235                 240 


Gly Ala His Leu Asp Leu Ser Ala Phe Ser Ser Trp Glu Glu Leu Ala 
                245                 250                 255     


Ser Leu Gly Leu Asp Arg Leu Lys Ser Ala Leu Leu Ala Leu Gly Leu 
            260                 265                 270         


Lys Cys Gly Gly Thr Leu Glu Glu Arg Ala Gln Arg Leu Phe Ser Thr 
        275                 280                 285             


Lys Gly Lys Ser Leu Glu Ser Leu Asp Thr Ser Leu Phe Ala Lys Asn 
    290                 295                 300                 


Pro Lys Ser Lys Gly Thr Lys Arg Asp Thr Glu Arg Asn Lys Asp Ile 
305                 310                 315                 320 


Ala Phe Leu Glu Ala Gln Ile Tyr Glu Tyr Val Glu Ile Leu Gly Glu 
                325                 330                 335     


Gln Arg His Leu Thr His Glu Asn Val Gln Arg Lys Gln Ala Arg Thr 
            340                 345                 350         


Gly Glu Glu Arg Glu Glu Glu Glu Glu Glu Gln Ile Ser Glu Ser Glu 
        355                 360                 365             


Ser Glu Asp Glu Glu Asn Glu Ile Ile Tyr Asn Pro Lys Asn Leu Pro 
    370                 375                 380                 


Leu Gly Trp Asp Gly Lys Pro Ile Pro Tyr Trp Leu Tyr Lys Leu His 
385                 390                 395                 400 


Gly Leu Asn Ile Asn Tyr Asn Cys Glu Ile Cys Gly Asn Tyr Thr Tyr 
                405                 410                 415     


Arg Gly Pro Lys Ala Phe Gln Arg His Phe Ala Glu Trp Arg His Ala 
            420                 425                 430         


His Gly Met Arg Cys Leu Gly Ile Pro Asn Thr Ala His Phe Ala Asn 
        435                 440                 445             


Val Thr Gln Ile Glu Asp Ala Val Ser Leu Trp Ala Lys Leu Lys Leu 
    450                 455                 460                 


Gln Lys Ala Ser Glu Arg Trp Gln Pro Asp Thr Glu Glu Glu Tyr Glu 
465                 470                 475                 480 


Asp Ser Ser Gly Asn Val Val Asn Lys Lys Thr Tyr Glu Asp Leu Lys 
                485                 490                 495     


Arg Gln Gly Leu Leu 
            500     


<210>  6101
<211>  303
<212>  DNA
<213>  Homosapiens

<400>  6101
aggaagaata tgaagactca agtgggaatg ttgtgaataa gaagacatac gaggatctga     60

aaagacaagg actgctctag tgttcaggga tccatggtag agttgggtag agttgagcag    120

ctgccccagg atccaaatgt ggtgtctgaa atggaaagaa ctaaggcaac caggaaggca    180

ctgatctgcc ttataagcac agtcatctga aagtcaggcc tgctgcagga caggatcccc    240

cagagacccc atttgcctct caacactcag accttcaact gttttttaat aaatctactt    300

ttt                                                                  303


<210>  6102
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  6102

Met Val Glu Leu Gly Arg Val Glu Gln Leu Pro Gln Asp Pro Asn Val 
1               5                   10                  15      


Val Ser Glu Met Glu Arg Thr Lys Ala Thr Arg Lys Ala Leu Ile Cys 
            20                  25                  30          


Leu Ile Ser Thr Val Ile 
        35              


<210>  6103
<211>  899
<212>  DNA
<213>  Homosapiens

<400>  6103
gggcgacaga gcgagagtcc gtctcaaaaa aaaagattca agttgttctt tccctggttt     60

gtatctgttt ttttcttgtg tatacttgtc tgatcactcc ttctgaagct acaatgattt    120

ttttggatgt ctttaccttt tctccttcat agagattgtt attgaactat tagaattttt    180

atattatgag ctttaagaaa gtaaagtcac tttccccatt attctcatag gttgttccac    240

attaacctcc ttcaagagta tcagtttctc tgttttcgga ggtctttggt tatatttgat    300

ccaactttta tagcaaagca agatcatgat gaattttgca gtggaaaggg ttttgtctat    360

aggtggtcca gaaccaaaac tctggtttgg ggtaggcaag aatctcaaag gcagagtctt    420

ctagggagca tcctaatggc agggagagag gattataaca ctggataccc aacagatgtt    480

cagtccatcc tgattgctgt tcatttctca tcctgcagtg tgggccaaac tgaaattgca    540

gaaggcttca gaacgatggc agcctgacac tgaggaagaa tatgaagact caagtgggaa    600

tgttgtgaat aagaagacat acgaggatct gaaaagacaa ggactgctct agtgttcagg    660

gatgtagctc agcttttggg ctagcccagg cttccctaag atctgctttt tctatttctc    720

ccaaccaaat cctcttaaag accctttgct atgtagtctc atggtctagc atgcatcttg    780

tagaaacaag gcatgctggc agattgcagg gttgagatgt gttttatctg ttttatattt    840

taaaagattc tgccagaaaa taaaaccaga ccttgttcta aagcccaggg ttatggacc     899


<210>  6104
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  6104

Met Ala Gly Arg Glu Asp Tyr Asn Thr Gly Tyr Pro Thr Asp Val Gln 
1               5                   10                  15      


Ser Ile Leu Ile Ala Val His Phe Ser Ser Cys Ser Val Gly Gln Thr 
            20                  25                  30          


Glu Ile Ala Glu Gly Phe Arg Thr Met Ala Ala 
        35                  40              


<210>  6105
<211>  818
<212>  DNA
<213>  Homosapiens

<400>  6105
ctggagagtt tagacttact gctagattgg ctgtgaaatg tgtggtcctg ccacagcctc     60

aggaacaccc accctctggc ctgcatttgg ggtttcccaa aaatctgtta atgtaatatt    120

gtaatttttc tcttctttgt ataggagttg gcttctctgg gtttggacag attgaaatct    180

gctctcttag ctttaggctt gaaatgtggc gggtaaggaa tagtttttct atcaaaacta    240

tcgatttact gtgtgtttgc acagtcttct aagtagctct gattccattt tttttgttgc    300

tccacactgc aaaaataagc cagcctgtgt ggtaaagtaa ccctaaaatc ctttgccgtc    360

ctgtctcctt aggaccctag aagagcgagc ccagagacta ttcagtacca aaggaaagtc    420

cctggagtca cttgatacct ctttgtttgc caaaaatccc aagtcaaagg gcaccaagcg    480

gtgagtggct ggggaagaat atgaagactc aagtgggaat gttgtgaata agaagacata    540

cgaggatctg aaaagacaag gactgctcta gtgttcaggg atgtagctca gcttttgggc    600

tagcccaggc ttccctaaga tctgcttttt ctatttctcc caaccaaatc ctcttaaaga    660

ccctttgcta tgtagtctca tggtctagca tgcatcttgt agaaacaagg catgctggca    720

gattgcaggg ttgagatgtg ttttatctgt tttatatttt aaaagattct gccagaaaat    780

aaaaccagac cttgttctaa agcccagggt tatggacc                            818


<210>  6106
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  6106

Asn Pro Leu Pro Ser Cys Leu Leu Arg Thr Leu Glu Glu Arg Ala Gln 
1               5                   10                  15      


Arg Leu Phe Ser Thr Lys Gly Lys Ser Leu Glu Ser Leu Asp Thr Ser 
            20                  25                  30          


Leu Phe Ala Lys Asn Pro Lys Ser Lys Gly Thr Lys Arg 
        35                  40                  45  


<210>  6107
<211>  2019
<212>  DNA
<213>  Homosapiens

<400>  6107
tttcctatgc cccctggagg catctgcgaa cctctcggca tcgctccacc acacctccca     60

ccagcaggtg gcactgttgc catctccata acatggactg gccttccttg tggtgctcct    120

gttttcttaa gtcccggggc acttccggca ctcgcggaac tttggtgcag cctgatgcgc    180

aacgtgggga ctcaggcgcg ctgggcggca ggagttgctt ccggccgtgt tggtggtctg    240

aattgagaag ccgcgactaa gggaagatgg agacaatact ggagcagcag cggcgctatc    300

atgaggagaa ggaacggctc atggacgtca tggctaaaga gatgctcacc aagaagtcca    360

cgctccggga ccagatcaat tctgatcacc gcactcgggc catgcaagat aggtatatgg    420

aggtcagtgg gaacctgagg gatttgtatg atgataagga tggattacga aaggaggagc    480

tcaatgccat ttcaggaccc aatgagtttg ctgaattcta taatagactc aagcaaataa    540

aggaattcca ccggaagcac ccaaatgaga tctgtgtgcc aatgtcagtg gaatttgagg    600

aactcctgaa ggctcgagag aatccaagtg aagaggcaca aaacttggtg gagttcacag    660

atgaagaggg atatggtcgt tatctcgatc tccatgactg ttacctcaag tacattaacc    720

tgaaggcatc tgagaagctg gattatatca catacctgtc catctttgac caattatttg    780

acattcctaa agaaaggaag aatgcagagt ataagagata cctagagatg ctgcttgagt    840

accttcagga ttacacagat agagtgaagc ctctccaaga tcagaatgaa ctttttggga    900

agattcaggc tgagtttgag aagaaatggg agaatgggac ctttcctgga tggccgaaag    960

agacaagcag tgccctgacc catgctggag cccatcttga cctctctgca ttctcctcct   1020

gggaggagtt ggcttctctg ggtttggaca gattgaaatc tgctctctta gctttaggct   1080

tgaaatgtgg cgggacccta gaagagcgag cccagagact attcagtacc aaaggaaagt   1140

ccctggagtc acttgatacc tctttgtttg ccaaaaatcc caagtcaaag ggcaccaagc   1200

gagacactga aaggaacaaa gacattgctt ttctagaagc ccagatctat gaatatgtag   1260

agattctcgg ggaacagcga catctcactc atgaaaatgt acagcgcaag caagccagga   1320

caggagaaga gcgagaagaa gaggaagaag agcagatcag tgagagtgag agtgaagatg   1380

aagagaacga gatcatttac aaccccaaaa acctgccact tggctgggat ggcaaaccta   1440

ttccctactg gctgtataag cttcatggcc taaatatcaa ctacaactgt gagatttgtg   1500

gaaactacac ctaccgaggg cccaaagcct tccagcgaca ctttgctgaa tggcgtcatg   1560

ctcatggcat gaggtgtttg ggcatcccaa acactgctca ctttgctaat gtgacacaga   1620

ttgaagatgc tgtctccttg tgggccaaac tgaaattgca gaaggcttca gaacgatggc   1680

agcctgacac tgaggaagaa tatgaagact caagtgggaa tgttgtgaat aagaagacat   1740

acgaggatct gaaaagacaa ggactgctct agtgttcagg gatgtagctc agcttttggg   1800

ctagcccagg cttccctaag atctgctttt tctatttctc ccaaccaaat cctcttaaag   1860

accctttgct atgtagtctc atggtctagc atgcatcttg tagaaacaag gcatgctggc   1920

agattgcagg gttgagatgt gttttatctg ttttatattt taaaagattc tgccagaaaa   1980

taaaaccaga ccttgttcta aagcccaggg ttatggacc                          2019


<210>  6108
<211>  501
<212>  PRT
<213>  Homosapiens

<400>  6108

Met Glu Thr Ile Leu Glu Gln Gln Arg Arg Tyr His Glu Glu Lys Glu 
1               5                   10                  15      


Arg Leu Met Asp Val Met Ala Lys Glu Met Leu Thr Lys Lys Ser Thr 
            20                  25                  30          


Leu Arg Asp Gln Ile Asn Ser Asp His Arg Thr Arg Ala Met Gln Asp 
        35                  40                  45              


Arg Tyr Met Glu Val Ser Gly Asn Leu Arg Asp Leu Tyr Asp Asp Lys 
    50                  55                  60                  


Asp Gly Leu Arg Lys Glu Glu Leu Asn Ala Ile Ser Gly Pro Asn Glu 
65                  70                  75                  80  


Phe Ala Glu Phe Tyr Asn Arg Leu Lys Gln Ile Lys Glu Phe His Arg 
                85                  90                  95      


Lys His Pro Asn Glu Ile Cys Val Pro Met Ser Val Glu Phe Glu Glu 
            100                 105                 110         


Leu Leu Lys Ala Arg Glu Asn Pro Ser Glu Glu Ala Gln Asn Leu Val 
        115                 120                 125             


Glu Phe Thr Asp Glu Glu Gly Tyr Gly Arg Tyr Leu Asp Leu His Asp 
    130                 135                 140                 


Cys Tyr Leu Lys Tyr Ile Asn Leu Lys Ala Ser Glu Lys Leu Asp Tyr 
145                 150                 155                 160 


Ile Thr Tyr Leu Ser Ile Phe Asp Gln Leu Phe Asp Ile Pro Lys Glu 
                165                 170                 175     


Arg Lys Asn Ala Glu Tyr Lys Arg Tyr Leu Glu Met Leu Leu Glu Tyr 
            180                 185                 190         


Leu Gln Asp Tyr Thr Asp Arg Val Lys Pro Leu Gln Asp Gln Asn Glu 
        195                 200                 205             


Leu Phe Gly Lys Ile Gln Ala Glu Phe Glu Lys Lys Trp Glu Asn Gly 
    210                 215                 220                 


Thr Phe Pro Gly Trp Pro Lys Glu Thr Ser Ser Ala Leu Thr His Ala 
225                 230                 235                 240 


Gly Ala His Leu Asp Leu Ser Ala Phe Ser Ser Trp Glu Glu Leu Ala 
                245                 250                 255     


Ser Leu Gly Leu Asp Arg Leu Lys Ser Ala Leu Leu Ala Leu Gly Leu 
            260                 265                 270         


Lys Cys Gly Gly Thr Leu Glu Glu Arg Ala Gln Arg Leu Phe Ser Thr 
        275                 280                 285             


Lys Gly Lys Ser Leu Glu Ser Leu Asp Thr Ser Leu Phe Ala Lys Asn 
    290                 295                 300                 


Pro Lys Ser Lys Gly Thr Lys Arg Asp Thr Glu Arg Asn Lys Asp Ile 
305                 310                 315                 320 


Ala Phe Leu Glu Ala Gln Ile Tyr Glu Tyr Val Glu Ile Leu Gly Glu 
                325                 330                 335     


Gln Arg His Leu Thr His Glu Asn Val Gln Arg Lys Gln Ala Arg Thr 
            340                 345                 350         


Gly Glu Glu Arg Glu Glu Glu Glu Glu Glu Gln Ile Ser Glu Ser Glu 
        355                 360                 365             


Ser Glu Asp Glu Glu Asn Glu Ile Ile Tyr Asn Pro Lys Asn Leu Pro 
    370                 375                 380                 


Leu Gly Trp Asp Gly Lys Pro Ile Pro Tyr Trp Leu Tyr Lys Leu His 
385                 390                 395                 400 


Gly Leu Asn Ile Asn Tyr Asn Cys Glu Ile Cys Gly Asn Tyr Thr Tyr 
                405                 410                 415     


Arg Gly Pro Lys Ala Phe Gln Arg His Phe Ala Glu Trp Arg His Ala 
            420                 425                 430         


His Gly Met Arg Cys Leu Gly Ile Pro Asn Thr Ala His Phe Ala Asn 
        435                 440                 445             


Val Thr Gln Ile Glu Asp Ala Val Ser Leu Trp Ala Lys Leu Lys Leu 
    450                 455                 460                 


Gln Lys Ala Ser Glu Arg Trp Gln Pro Asp Thr Glu Glu Glu Tyr Glu 
465                 470                 475                 480 


Asp Ser Ser Gly Asn Val Val Asn Lys Lys Thr Tyr Glu Asp Leu Lys 
                485                 490                 495     


Arg Gln Gly Leu Leu 
            500     


<210>  6109
<211>  981
<212>  DNA
<213>  Homosapiens

<400>  6109
tttcctatgc cccctggagg catctgcgaa cctctcggca tcgctccacc acacctccca     60

ccagcaggtg gcactgttgc catctccata acatggactg gccttccttg tggtgctcct    120

gttttcttaa gtcccggggc acttccggca ctcgcggaac tttggtgcag cctgatgcgc    180

aacgtgggga ctcaggcgcg ctgggcggca ggagttgctt ccggccgtgt tggtggtctg    240

aattgagaag ccgcgactaa gggaagatgg agacaatact ggagcagcag cggcgctatc    300

atgaggagaa ggaacggctc atggacgtca tggctaaaga gatgctcacc aagaagtcca    360

cgctccggga ccagatcaat tctgatcacc gcactcgggc catgcaagat aggtatatgg    420

aggtcagtgg gaacctgagg gatttgtatg atgataagga tggaaactac acctaccgag    480

ggcccaaagc cttccagcga cactttgctg aatggcgtca tgctcatggc atgaggtgtt    540

tgggcatccc aaacactgct cactttgcta atgtgacaca gattgaagat gctgtctcct    600

tgtgggccaa actgaaattg cagaaggctt cagaacgatg gcagcctgac actgaggaag    660

aatatgaaga ctcaagtggg aatgttgtga ataagaagac atacgaggat ctgaaaagac    720

aaggactgct ctagtgttca gggatgtagc tcagcttttg ggctagccca ggcttcccta    780

agatctgctt tttctatttc tcccaaccaa atcctcttaa agaccctttg ctatgtagtc    840

tcatggtcta gcatgcatct tgtagaaaca aggcatgctg gcagattgca gggttgagat    900

gtgttttatc tgttttatat tttaaaagat tctgccagaa aataaaacca gaccttgttc    960

taaagcccag ggttatggac c                                              981


<210>  6110
<211>  155
<212>  PRT
<213>  Homosapiens

<400>  6110

Met Glu Thr Ile Leu Glu Gln Gln Arg Arg Tyr His Glu Glu Lys Glu 
1               5                   10                  15      


Arg Leu Met Asp Val Met Ala Lys Glu Met Leu Thr Lys Lys Ser Thr 
            20                  25                  30          


Leu Arg Asp Gln Ile Asn Ser Asp His Arg Thr Arg Ala Met Gln Asp 
        35                  40                  45              


Arg Tyr Met Glu Val Ser Gly Asn Leu Arg Asp Leu Tyr Asp Asp Lys 
    50                  55                  60                  


Asp Gly Asn Tyr Thr Tyr Arg Gly Pro Lys Ala Phe Gln Arg His Phe 
65                  70                  75                  80  


Ala Glu Trp Arg His Ala His Gly Met Arg Cys Leu Gly Ile Pro Asn 
                85                  90                  95      


Thr Ala His Phe Ala Asn Val Thr Gln Ile Glu Asp Ala Val Ser Leu 
            100                 105                 110         


Trp Ala Lys Leu Lys Leu Gln Lys Ala Ser Glu Arg Trp Gln Pro Asp 
        115                 120                 125             


Thr Glu Glu Glu Tyr Glu Asp Ser Ser Gly Asn Val Val Asn Lys Lys 
    130                 135                 140                 


Thr Tyr Glu Asp Leu Lys Arg Gln Gly Leu Leu 
145                 150                 155 


<210>  6111
<211>  513
<212>  DNA
<213>  Homosapiens

<400>  6111
ggcgcggtgt ctcacgcctg taatcccagc actttgggag gctgaggtgg gcgggcagat     60

cacctgaggt tgggagttcg agaccagcct gaccaacatg gagaaacccc atctctacta    120

caaatacaaa attagccagg tgtggtggtg catgcctgta atccctgcta ctcaggaggc    180

tgaggcagga gaatcacttg aacccaggag gtggaggttg ggtgagccga gatcgcaccg    240

ctgcatccat ctcaaaaaaa aaaaaaaaaa aaaagaatat taataaagtg cgaccaatca    300

cctaaatggc gatttccggt ggcaatttca gagggctctt tcttagcttt tgtacagtta    360

aaaaaaaatc ataaatctaa accaatggaa taactaacat aataaattta taagtaaaac    420

cctctaagtt aaaaaaaaaa aaaaaatcac tgcggccggg tgcggtggct cacgccaatg    480

atattcttaa aaaaaaaaaa aaaaaaaaaa att                                 513


<210>  6112
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  6112

Met Glu Lys Pro His Leu Tyr Tyr Lys Tyr Lys Ile Ser Gln Val Trp 
1               5                   10                  15      


Trp Cys Met Pro Val Ile Pro Ala Thr Gln Glu Ala Glu Ala Gly Glu 
            20                  25                  30          


Ser Leu Glu Pro Arg Arg Trp Arg Leu Gly Glu Pro Arg Ser His Arg 
        35                  40                  45              


Cys Ile His Leu Lys Lys Lys Lys Lys Lys Lys Glu Tyr 
    50                  55                  60      


<210>  6113
<211>  710
<212>  DNA
<213>  Homosapiens

<400>  6113
tggtggtctg aattgagaag ccgcgactaa gggaagatgg agacaatact ggagcagcag     60

cggcgctatc atgaggagaa ggaacggctc atggacgtca tggctaaaga gatgctcacc    120

aagaagtcca cgctccggga ccagatcaat tctgatcacc gcactcgggc catgcaagat    180

atctgtgtgc caatgtcagt ggaatttgag gaactcctga aggctcgaga gaatccaagt    240

gaagaggcac aaaacttggt ggagttcaca gatgaagagg gatatggtcg ttatctcgat    300

ctccatgact gttacctcaa gtacattaac ctgaaggcat ctgagaagct ggattatatc    360

acatacctgt ccatctttga ccaattattt gacattccta aagaaaggaa gaatgcagag    420

tataagagat acctagagat gctgcttgag taccttcagg attacacaga tagagtgaag    480

cctctccaag atcagaatga actttttggg aagattcagg ctgagtttga gaagaaatgg    540

gagaatggga cctttcctgg atggccgaaa gagacaagca gtgccctgac ccatgctgga    600

gcccatcttg acctctctgc attctcctcc tgggaggtat gtttccttca gcagtagtag    660

tgttctctct gtctattttt ctgtctttaa agactgctct cctgtcttta               710


<210>  6114
<211>  206
<212>  PRT
<213>  Homosapiens

<400>  6114

Met Glu Thr Ile Leu Glu Gln Gln Arg Arg Tyr His Glu Glu Lys Glu 
1               5                   10                  15      


Arg Leu Met Asp Val Met Ala Lys Glu Met Leu Thr Lys Lys Ser Thr 
            20                  25                  30          


Leu Arg Asp Gln Ile Asn Ser Asp His Arg Thr Arg Ala Met Gln Asp 
        35                  40                  45              


Ile Cys Val Pro Met Ser Val Glu Phe Glu Glu Leu Leu Lys Ala Arg 
    50                  55                  60                  


Glu Asn Pro Ser Glu Glu Ala Gln Asn Leu Val Glu Phe Thr Asp Glu 
65                  70                  75                  80  


Glu Gly Tyr Gly Arg Tyr Leu Asp Leu His Asp Cys Tyr Leu Lys Tyr 
                85                  90                  95      


Ile Asn Leu Lys Ala Ser Glu Lys Leu Asp Tyr Ile Thr Tyr Leu Ser 
            100                 105                 110         


Ile Phe Asp Gln Leu Phe Asp Ile Pro Lys Glu Arg Lys Asn Ala Glu 
        115                 120                 125             


Tyr Lys Arg Tyr Leu Glu Met Leu Leu Glu Tyr Leu Gln Asp Tyr Thr 
    130                 135                 140                 


Asp Arg Val Lys Pro Leu Gln Asp Gln Asn Glu Leu Phe Gly Lys Ile 
145                 150                 155                 160 


Gln Ala Glu Phe Glu Lys Lys Trp Glu Asn Gly Thr Phe Pro Gly Trp 
                165                 170                 175     


Pro Lys Glu Thr Ser Ser Ala Leu Thr His Ala Gly Ala His Leu Asp 
            180                 185                 190         


Leu Ser Ala Phe Ser Ser Trp Glu Val Cys Phe Leu Gln Gln 
        195                 200                 205     


<210>  6115
<211>  372
<212>  DNA
<213>  Homosapiens

<400>  6115
acatcttgca gcaggtagca gctcgagtgg aaaaggcaag acttgctgcc tggagtgggg     60

atgaagaaac atttaggggc aggaaggcat caggtttgag acacagtgac tggaggatgg    120

tggtggtaag gcggtccacc cacctaacag gaagtgagag atgtgcagct acaaaattgt    180

ttgatttatt tcaatacaaa catttttcag acttaacata aaagaaaccc agacatataa    240

tcaaaggtgt gtcattgttt aattgacaat tttttctctc ttccttagta aagcataaaa    300

taatactgag ttttacattt gatggcatct cgtattcaag aaatacagta gctctccaag    360

tttatacccc cc                                                        372


<210>  6116
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  6116

Met Val Val Val Arg Arg Ser Thr His Leu Thr Gly Ser Glu Arg Cys 
1               5                   10                  15      


Ala Ala Thr Lys Leu Phe Asp Leu Phe Gln Tyr Lys His Phe Ser Asp 
            20                  25                  30          


Leu Thr 
        


<210>  6117
<211>  668
<212>  DNA
<213>  Homosapiens

<400>  6117
tgcgcccgct gctctacctc cctggtgggc cagggcttcg taccggatgg agaccaagtg     60

ctctgccagg gctgtagcca ggcagggccc taagccaggg ctcctggacc caggctttcc    120

cataccacgg gcccaggact gtggctcctt ttctaaacca cctctgggac tcagctcccc    180

ccgccaaaaa aaatggggcc ccaaacctgg gctcttacag agcctccatg agtcaagccc    240

cctccccaca cctggactcc agaattcacc ctctcccctg cagtctgggt tcccagactg    300

agtcctctcc ccaaatcagg gctctagacc cgagccctcc aaacctggac tctgggactt    360

aggccccctt aaatctagac ttctctttat aggtttcagg tctcctatgg gtgcctggga    420

agtccttgaa agtggactgt tctcaggctt gacctgcccc accccatccc cgcggttgag    480

gctgtggggg cagcagatca ggagcccact gataaggggc cctagggtac agggtgctgc    540

ccagcaggtc gccaccgagt gtcttctcat tttatttcag ctccattttg cccatagatg    600

ggcagagggg tgagattggc tcatccccct tccagattct gcaataaagc ggtgtgagga    660

agcagggg                                                             668


<210>  6118
<211>  84
<212>  PRT
<213>  Homosapiens

<400>  6118

Met Glu Thr Lys Cys Ser Ala Arg Ala Val Ala Arg Gln Gly Pro Lys 
1               5                   10                  15      


Pro Gly Leu Leu Asp Pro Gly Phe Pro Ile Pro Arg Ala Gln Asp Cys 
            20                  25                  30          


Gly Ser Phe Ser Lys Pro Pro Leu Gly Leu Ser Ser Pro Arg Gln Lys 
        35                  40                  45              


Lys Trp Gly Pro Lys Pro Gly Leu Leu Gln Ser Leu His Glu Ser Ser 
    50                  55                  60                  


Pro Leu Pro Thr Pro Gly Leu Gln Asn Ser Pro Ser Pro Leu Gln Ser 
65                  70                  75                  80  


Gly Phe Pro Asp 
                


<210>  6119
<211>  845
<212>  DNA
<213>  Homosapiens

<400>  6119
gagaactctt tgcacctaag tgcagcagct gcaagcgccc catcgtagga ctcggtggag     60

gcaagtatgt gtcctttgaa gaccgacact ggcaccacaa ctgcttctcc tgcgcccgct    120

gctctacctc cctggtgggc cagggcttcg taccggatgg agaccaagtg ctctgccagg    180

gctgtagcca ggcagggccc taagccaggg ctcctggacc caggctttcc cataccacgg    240

gcccaggact gtggctcctt ttctaaacca cctctgggac tcagctcccc ccgccaaaaa    300

aaatgggtct ccttctgggc tccaggattg tctccccact ccagcatccc caaactggta    360

ctccctgacc cagggcccca aacctgggct cttacagagc ctccatgagt caagccccct    420

ccccacacct ggactccaga attcaccctc tcccctgcag tctgggttcc cagactgagt    480

cctctcccca aatcagggct ctagacccga gccctccaaa cctggactct gggacttagg    540

cccccttaaa tctagacttc tctttatagg tttcaggtct cctatgggtg cctgggaagt    600

ccttgaaagt ggactgttct caggcttgac ctgccccacc ccatccccgc ggttgaggct    660

gtgggggcag cagatcagga gcccactgat aaggggccct agggtacagg gtgctgccca    720

gcaggtcgcc accgagtgtc ttctcatttt atttcagctc cattttgccc atagatgggc    780

agaggggtga gattggctca tcccccttcc agattctgca ataaagcggt gtgaggaagc    840

agggg                                                                845


<210>  6120
<211>  113
<212>  PRT
<213>  Homosapiens

<400>  6120

Met Cys Pro Leu Lys Thr Asp Thr Gly Thr Thr Thr Ala Ser Pro Ala 
1               5                   10                  15      


Pro Ala Ala Leu Pro Pro Trp Trp Ala Arg Ala Ser Tyr Arg Met Glu 
            20                  25                  30          


Thr Lys Cys Ser Ala Arg Ala Val Ala Arg Gln Gly Pro Lys Pro Gly 
        35                  40                  45              


Leu Leu Asp Pro Gly Phe Pro Ile Pro Arg Ala Gln Asp Cys Gly Ser 
    50                  55                  60                  


Phe Ser Lys Pro Pro Leu Gly Leu Ser Ser Pro Arg Gln Lys Lys Trp 
65                  70                  75                  80  


Val Ser Phe Trp Ala Pro Gly Leu Ser Pro His Ser Ser Ile Pro Lys 
                85                  90                  95      


Leu Val Leu Pro Asp Pro Gly Pro Gln Thr Trp Ala Leu Thr Glu Pro 
            100                 105                 110         


Pro 
    


<210>  6121
<211>  1475
<212>  DNA
<213>  Homosapiens

<400>  6121
ggtccgtctg cagtcggcag cctcgccggc agctcgctcg gcccccgctt ggcccggccc     60

gcaggtagga gccgccgagg gacgcggcgc ccggttcccg gccccgcctg cgccgcgcgc    120

tccccgctcc cgccgcccgc ttcgaggagc tgttctatga agaccgccat ttccacgagg    180

gctgcttccg ctgctgccgc tgccagcgct cactagccga tgaacccttc acctgccagg    240

acagtgagct gctctgcaat gactgctact gcagtgcgtt ttcctcgcag tgctccgctt    300

gtggggagac tgtcatgcct gggtcccgga agctggaata tggaggccag acatggcatg    360

agcactgctt cctgtgcagt ggctgtgaac agccactggg ctcccgttct tttgtgcccg    420

acaagggtgc tcactactgc gtgccctgct atgagaacaa gtttgctcct cgctgcgccc    480

gctgcagcaa gacgctgaca cagggtggag tgacataccg tgatcagccg tggcatcgag    540

aatgtctggt ctgtaccgga tgccagacgc ccctggcagg gcagcagttc acctcccggg    600

atgaagatcc ctactgtgtg gcctgttttg gagaactctt tgcacctaag tgcagcagct    660

gcaagcgccc catcgtagga ctcggtggag gcaagtatgt gtcctttgaa gaccgacact    720

ggcaccacaa ctgcttctcc tgcgcccgct gctctacctc cctggtgggc cagggcttcg    780

taccggatgg agaccaagtg ctctgccagg gctgtagcca ggcagggccc taagccaggg    840

ctcctggacc caggctttcc cataccacgg gcccaggact gtggctcctt ttctaaacca    900

cctctgggac tcagctcccc ccgccaaaaa aaatgggtct ccttctgggc tccaggattg    960

tctccccact ccagcatccc caaactggta ctccctgacc cagggcccca aacctgggct   1020

cttacagagc ctccatgagt caagccccct ccccacacct ggactccaga attcaccctc   1080

tcccctgcag tctgggttcc cagactgagt cctctcccca aatcagggct ctagacccga   1140

gccctccaaa cctggactct gggacttagg cccccttaaa tctagacttc tctttatagg   1200

tttcaggtct cctatgggtg cctgggaagt ccttgaaagt ggactgttct caggcttgac   1260

ctgccccacc ccatccccgc ggttgaggct gtgggggcag cagatcagga gcccactgat   1320

aaggggccct agggtacagg gtgctgccca gcaggtcgcc accgagtgtc ttctcatttt   1380

atttcagctc cattttgccc atagatgggc agaggggtga gattggctca tcccccttcc   1440

agattctgca ataaagcggt gtgaggaagc agggg                              1475


<210>  6122
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  6122

Met Pro Gly Ser Arg Lys Leu Glu Tyr Gly Gly Gln Thr Trp His Glu 
1               5                   10                  15      


His Cys Phe Leu Cys Ser Gly Cys Glu Gln Pro Leu Gly Ser Arg Ser 
            20                  25                  30          


Phe Val Pro Asp Lys Gly Ala His Tyr Cys Val Pro Cys Tyr Glu Asn 
        35                  40                  45              


Lys Phe Ala Pro Arg Cys Ala Arg Cys Ser Lys Thr Leu Thr Gln Gly 
    50                  55                  60                  


Gly Val Thr Tyr Arg Asp Gln Pro Trp His Arg Glu Cys Leu Val Cys 
65                  70                  75                  80  


Thr Gly Cys Gln Thr Pro Leu Ala Gly Gln Gln Phe Thr Ser Arg Asp 
                85                  90                  95      


Glu Asp Pro Tyr Cys Val Ala Cys Phe Gly Glu Leu Phe Ala Pro Lys 
            100                 105                 110         


Cys Ser Ser Cys Lys Arg Pro Ile Val Gly Leu Gly Gly Gly Lys Tyr 
        115                 120                 125             


Val Ser Phe Glu Asp Arg His Trp His His Asn Cys Phe Ser Cys Ala 
    130                 135                 140                 


Arg Cys Ser Thr Ser Leu Val Gly Gln Gly Phe Val Pro Asp Gly Asp 
145                 150                 155                 160 


Gln Val Leu Cys Gln Gly Cys Ser Gln Ala Gly Pro 
                165                 170         


<210>  6123
<211>  1393
<212>  DNA
<213>  Homosapiens

<400>  6123
ggtccgtctg cagtcggcag cctcgccggc agctcgctcg gcccccgctt ggcccggccc     60

gcaggagctg ttctatgaag accgccattt ccacgagggc tgcttccgct gctgccgctg    120

ccagcgctca ctagccgatg aacccttcac ctgccaggac agtgagctgc tctgcaatga    180

ctgctactgc agtgcgtttt cctcgcagtg ctccgcttgt ggggagactg tcatgcctgg    240

gtcccggaag ctggaatatg gaggccagac atggcatgag cactgcttcc tgtgcagtgg    300

ctgtgaacag ccactgggct cccgttcttt tgtgcccgac aagggtgctc actactgcgt    360

gccctgctat gagaacaagt ttgctcctcg ctgcgcccgc tgcagcaaga cgctgacaca    420

gggtggagtg acataccgtg atcagccgtg gcatcgagaa tgtctggtct gtaccggatg    480

ccagacgccc ctggcagggc agcagttcac ctcccgggat gaagatccct actgtgtggc    540

ctgttttgga gaactctttg cacctaagtg cagcagctgc aagcgcccca tcgtaggact    600

cggtggaggc aagtatgtgt cctttgaaga ccgacactgg caccacaact gcttctcctg    660

cgcccgctgc tctacctccc tggtgggcca gggcttcgta ccggatggag accaagtgct    720

ctgccagggc tgtagccagg cagggcccta agccagggct cctggaccca ggctttccca    780

taccacgggc ccaggactgt ggctcctttt ctaaaccacc tctgggactc agctcccccc    840

gccaaaaaaa atgggtctcc ttctgggctc caggattgtc tccccactcc agcatcccca    900

aactggtact ccctgaccca gggccccaaa cctgggctct tacagagcct ccatgagtca    960

agccccctcc ccacacctgg actccagaat tcaccctctc ccctgcagtc tgggttccca   1020

gactgagtcc tctccccaaa tcagggctct agacccgagc cctccaaacc tggactctgg   1080

gacttaggcc cccttaaatc tagacttctc tttataggtt tcaggtctcc tatgggtgcc   1140

tgggaagtcc ttgaaagtgg actgttctca ggcttgacct gccccacccc atccccgcgg   1200

ttgaggctgt gggggcagca gatcaggagc ccactgataa ggggccctag ggtacagggt   1260

gctgcccagc aggtcgccac cgagtgtctt ctcattttat ttcagctcca ttttgcccat   1320

agatgggcag aggggtgaga ttggctcatc ccccttccag attctgcaat aaagcggtgt   1380

gaggaagcag ggg                                                      1393


<210>  6124
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  6124

Met Pro Gly Ser Arg Lys Leu Glu Tyr Gly Gly Gln Thr Trp His Glu 
1               5                   10                  15      


His Cys Phe Leu Cys Ser Gly Cys Glu Gln Pro Leu Gly Ser Arg Ser 
            20                  25                  30          


Phe Val Pro Asp Lys Gly Ala His Tyr Cys Val Pro Cys Tyr Glu Asn 
        35                  40                  45              


Lys Phe Ala Pro Arg Cys Ala Arg Cys Ser Lys Thr Leu Thr Gln Gly 
    50                  55                  60                  


Gly Val Thr Tyr Arg Asp Gln Pro Trp His Arg Glu Cys Leu Val Cys 
65                  70                  75                  80  


Thr Gly Cys Gln Thr Pro Leu Ala Gly Gln Gln Phe Thr Ser Arg Asp 
                85                  90                  95      


Glu Asp Pro Tyr Cys Val Ala Cys Phe Gly Glu Leu Phe Ala Pro Lys 
            100                 105                 110         


Cys Ser Ser Cys Lys Arg Pro Ile Val Gly Leu Gly Gly Gly Lys Tyr 
        115                 120                 125             


Val Ser Phe Glu Asp Arg His Trp His His Asn Cys Phe Ser Cys Ala 
    130                 135                 140                 


Arg Cys Ser Thr Ser Leu Val Gly Gln Gly Phe Val Pro Asp Gly Asp 
145                 150                 155                 160 


Gln Val Leu Cys Gln Gly Cys Ser Gln Ala Gly Pro 
                165                 170         


<210>  6125
<211>  1673
<212>  DNA
<213>  Homosapiens

<400>  6125
ggcccccgcg gcgggctggg gggccggggg cggggtccgg gcggggcggg cccgcgctca     60

cttcctcggg gaggggttgg ggccgcgctc ccactcgccc acacggtccg tctgcagtcg    120

gcagcctcgc cggcagctcg ctcggccccc gcttggcccg gcccgcaggg ttctctcccc    180

ttgccaccat gagcgagtca tttgactgtg caaaatgcaa cgagtccctg tatggacgca    240

agtacatcca gacagacagc ggcccctact gtgtgccctg ctatgacaat acctttgcca    300

acacctgtgc tgagtgccag cagcttatcg ggcatgactc gagggagctg ttctatgaag    360

accgccattt ccacgagggc tgcttccgct gctgccgctg ccagcgctca ctagccgatg    420

aacccttcac ctgccaggac agtgagctgc tctgcaatga ctgctactgc agtgcgtttt    480

cctcgcagtg ctccgcttgt ggggagactg tcatgcctgg gtcccggaag ctggaatatg    540

gaggccagac atggcatgag cactgcttcc tgtgcagtgg ctgtgaacag ccactgggct    600

cccgttcttt tgtgcccgac aagggtgctc actactgcgt gccctgctat gagaacaagt    660

ttgctcctcg ctgcgcccgc tgcagcaaga cgctgacaca gggtggagtg acataccgtg    720

atcagccgtg gcatcgagaa tgtctggtct gtaccggatg ccagacgccc ctggcagggc    780

agcagttcac ctcccgggat gaagatccct actgtgtggc ctgttttgga gaactctttg    840

cacctaagtg cagcagctgc aagcgcccca tcgtaggact cggtggaggc aagtatgtgt    900

cctttgaaga ccgacactgg caccacaact gcttctcctg cgcccgctgc tctacctccc    960

tggtgggcca gggcttcgta ccggatggag accaagtgct ctgccagggc tgtagccagg   1020

cagggcccta agccagggct cctggaccca ggctttccca taccacgggc ccaggactgt   1080

ggctcctttt ctaaaccacc tctgggactc agctcccccc gccaaaaaaa atgggtctcc   1140

ttctgggctc caggattgtc tccccactcc agcatcccca aactggtact ccctgaccca   1200

gggccccaaa cctgggctct tacagagcct ccatgagtca agccccctcc ccacacctgg   1260

actccagaat tcaccctctc ccctgcagtc tgggttccca gactgagtcc tctccccaaa   1320

tcagggctct agacccgagc cctccaaacc tggactctgg gacttaggcc cccttaaatc   1380

tagacttctc tttataggtt tcaggtctcc tatgggtgcc tgggaagtcc ttgaaagtgg   1440

actgttctca ggcttgacct gccccacccc atccccgcgg ttgaggctgt gggggcagca   1500

gatcaggagc ccactgataa ggggccctag ggtacagggt gctgcccagc aggtcgccac   1560

cgagtgtctt ctcattttat ttcagctcca ttttgcccat agatgggcag aggggtgaga   1620

ttggctcatc ccccttccag attctgcaat aaagcggtgt gaggaagcag ggg          1673


<210>  6126
<211>  280
<212>  PRT
<213>  Homosapiens

<400>  6126

Met Ser Glu Ser Phe Asp Cys Ala Lys Cys Asn Glu Ser Leu Tyr Gly 
1               5                   10                  15      


Arg Lys Tyr Ile Gln Thr Asp Ser Gly Pro Tyr Cys Val Pro Cys Tyr 
            20                  25                  30          


Asp Asn Thr Phe Ala Asn Thr Cys Ala Glu Cys Gln Gln Leu Ile Gly 
        35                  40                  45              


His Asp Ser Arg Glu Leu Phe Tyr Glu Asp Arg His Phe His Glu Gly 
    50                  55                  60                  


Cys Phe Arg Cys Cys Arg Cys Gln Arg Ser Leu Ala Asp Glu Pro Phe 
65                  70                  75                  80  


Thr Cys Gln Asp Ser Glu Leu Leu Cys Asn Asp Cys Tyr Cys Ser Ala 
                85                  90                  95      


Phe Ser Ser Gln Cys Ser Ala Cys Gly Glu Thr Val Met Pro Gly Ser 
            100                 105                 110         


Arg Lys Leu Glu Tyr Gly Gly Gln Thr Trp His Glu His Cys Phe Leu 
        115                 120                 125             


Cys Ser Gly Cys Glu Gln Pro Leu Gly Ser Arg Ser Phe Val Pro Asp 
    130                 135                 140                 


Lys Gly Ala His Tyr Cys Val Pro Cys Tyr Glu Asn Lys Phe Ala Pro 
145                 150                 155                 160 


Arg Cys Ala Arg Cys Ser Lys Thr Leu Thr Gln Gly Gly Val Thr Tyr 
                165                 170                 175     


Arg Asp Gln Pro Trp His Arg Glu Cys Leu Val Cys Thr Gly Cys Gln 
            180                 185                 190         


Thr Pro Leu Ala Gly Gln Gln Phe Thr Ser Arg Asp Glu Asp Pro Tyr 
        195                 200                 205             


Cys Val Ala Cys Phe Gly Glu Leu Phe Ala Pro Lys Cys Ser Ser Cys 
    210                 215                 220                 


Lys Arg Pro Ile Val Gly Leu Gly Gly Gly Lys Tyr Val Ser Phe Glu 
225                 230                 235                 240 


Asp Arg His Trp His His Asn Cys Phe Ser Cys Ala Arg Cys Ser Thr 
                245                 250                 255     


Ser Leu Val Gly Gln Gly Phe Val Pro Asp Gly Asp Gln Val Leu Cys 
            260                 265                 270         


Gln Gly Cys Ser Gln Ala Gly Pro 
        275                 280 


<210>  6127
<211>  1809
<212>  DNA
<213>  Homosapiens

<400>  6127
gggaggaggg ggccgggccg actggcggcc gaaagggagg tgggggcggg gtctggcccc     60

cgcggcgggc tggggggccg ggggcggggt ccgggcgggg cgggcccgcg ctcacttcct    120

cggggagggg ttggggccgc gctcccactc gcccacacgg tccgtctgca gtcggcagcc    180

tcgccggcag ctcgctcggc ccccgcttgg cccggcccgc aggtaggagc cgccgaggga    240

cgcggcgccc ggttcccggc cccgcctgcg ccgcgcgctc cccgctcccg ccgcccgctt    300

cgagggttct ctccccttgc caccatgagc gagtcatttg actgtgcaaa atgcaacgag    360

tccctgtatg gacgcaagta catccagaca gacagcggcc cctactgtgt gccctgctat    420

gacaatacct ttgccaacac ctgtgctgag tgccagcagc ttatcgggca tgactcgagg    480

gagctgttct atgaagaccg ccatttccac gagggctgct tccgctgctg ccgctgccag    540

cgctcactag ccgatgaacc cttcacctgc caggacagtg agctgctctg caatgactgc    600

tactgcagtg cgttttcctc gcagtgctcc gcttgtgggg agactgtcat gcctgggtcc    660

cggaagctgg aatatggagg ccagacatgg catgagcact gcttcctgtg cagtggctgt    720

gaacagccac tgggctcccg ttcttttgtg cccgacaagg gtgctcacta ctgcgtgccc    780

tgctatgaga acaagtttgc tcctcgctgc gcccgctgca gcaagacgct gacacagggt    840

ggagtgacat accgtgatca gccgtggcat cgagaatgtc tggtctgtac cggatgccag    900

acgcccctgg cagggcagca gttcacctcc cgggatgaag atccctactg tgtggcctgt    960

tttggagaac tctttgcacc taagtgcagc agctgcaagc gccccatcgt aggactcggt   1020

ggaggcaagt atgtgtcctt tgaagaccga cactggcacc acaactgctt ctcctgcgcc   1080

cgctgctcta cctccctggt gggccagggc ttcgtaccgg atggagacca agtgctctgc   1140

cagggctgta gccaggcagg gccctaagcc agggctcctg gacccaggct ttcccatacc   1200

acgggcccag gactgtggct ccttttctaa accacctctg ggactcagct ccccccgcca   1260

aaaaaaatgg gtctccttct gggctccagg attgtctccc cactccagca tccccaaact   1320

ggtactccct gacccagggc cccaaacctg ggctcttaca gagcctccat gagtcaagcc   1380

ccctccccac acctggactc cagaattcac cctctcccct gcagtctggg ttcccagact   1440

gagtcctctc cccaaatcag ggctctagac ccgagccctc caaacctgga ctctgggact   1500

taggccccct taaatctaga cttctcttta taggtttcag gtctcctatg ggtgcctggg   1560

aagtccttga aagtggactg ttctcaggct tgacctgccc caccccatcc ccgcggttga   1620

ggctgtgggg gcagcagatc aggagcccac tgataagggg ccctagggta cagggtgctg   1680

cccagcaggt cgccaccgag tgtcttctca ttttatttca gctccatttt gcccatagat   1740

gggcagaggg gtgagattgg ctcatccccc ttccagattc tgcaataaag cggtgtgagg   1800

aagcagggg                                                           1809


<210>  6128
<211>  280
<212>  PRT
<213>  Homosapiens

<400>  6128

Met Ser Glu Ser Phe Asp Cys Ala Lys Cys Asn Glu Ser Leu Tyr Gly 
1               5                   10                  15      


Arg Lys Tyr Ile Gln Thr Asp Ser Gly Pro Tyr Cys Val Pro Cys Tyr 
            20                  25                  30          


Asp Asn Thr Phe Ala Asn Thr Cys Ala Glu Cys Gln Gln Leu Ile Gly 
        35                  40                  45              


His Asp Ser Arg Glu Leu Phe Tyr Glu Asp Arg His Phe His Glu Gly 
    50                  55                  60                  


Cys Phe Arg Cys Cys Arg Cys Gln Arg Ser Leu Ala Asp Glu Pro Phe 
65                  70                  75                  80  


Thr Cys Gln Asp Ser Glu Leu Leu Cys Asn Asp Cys Tyr Cys Ser Ala 
                85                  90                  95      


Phe Ser Ser Gln Cys Ser Ala Cys Gly Glu Thr Val Met Pro Gly Ser 
            100                 105                 110         


Arg Lys Leu Glu Tyr Gly Gly Gln Thr Trp His Glu His Cys Phe Leu 
        115                 120                 125             


Cys Ser Gly Cys Glu Gln Pro Leu Gly Ser Arg Ser Phe Val Pro Asp 
    130                 135                 140                 


Lys Gly Ala His Tyr Cys Val Pro Cys Tyr Glu Asn Lys Phe Ala Pro 
145                 150                 155                 160 


Arg Cys Ala Arg Cys Ser Lys Thr Leu Thr Gln Gly Gly Val Thr Tyr 
                165                 170                 175     


Arg Asp Gln Pro Trp His Arg Glu Cys Leu Val Cys Thr Gly Cys Gln 
            180                 185                 190         


Thr Pro Leu Ala Gly Gln Gln Phe Thr Ser Arg Asp Glu Asp Pro Tyr 
        195                 200                 205             


Cys Val Ala Cys Phe Gly Glu Leu Phe Ala Pro Lys Cys Ser Ser Cys 
    210                 215                 220                 


Lys Arg Pro Ile Val Gly Leu Gly Gly Gly Lys Tyr Val Ser Phe Glu 
225                 230                 235                 240 


Asp Arg His Trp His His Asn Cys Phe Ser Cys Ala Arg Cys Ser Thr 
                245                 250                 255     


Ser Leu Val Gly Gln Gly Phe Val Pro Asp Gly Asp Gln Val Leu Cys 
            260                 265                 270         


Gln Gly Cys Ser Gln Ala Gly Pro 
        275                 280 


<210>  6129
<211>  2138
<212>  DNA
<213>  Homosapiens

<400>  6129
gttccctatc tgtcctcctc cctccctggg aaacaggtgt gtctgaactg gggctggaag     60

cagagcctga gagctggatg actggccttg ggcctatttc cggtaggaat cagtggactt    120

ggcggcagag gcagtgcgga tccggcgttc tccactgatc ttttccaagg ctgtacagac    180

atggcggcgg cttttcggaa ggcggctaag tcccggcagc gggaacacag agagcgaagc    240

cagcctggct ttcgaaaaca tctgggcctg ctggagaaaa agaaagatta caaacttcgt    300

gcagatgact accgtaaaaa acaagaatac ctcaaagctc ttcggaagaa ggctcttgaa    360

aaaaatccag atgaattcta ctacaaaatg actcgggtta aactccagga tggagtacat    420

attattaagg agactaagga agaagtaacc ccagaacaac taaagctgat gagaactcag    480

gacgtcaaat atatagaaat gaagagggtt gcagaagcta agaaaatcga aagactaaaa    540

tcagagctcc atctgctgga tttccagggg aagcaacaga acaagcatgt gttctttttt    600

gacaccaaaa aggaagttga acagtttgat gtcgcaactc acctgcaaac agccccggag    660

ctagtcgaca gagtctttaa taggcccagg atagagacct tgcagaaaga aaaagtgaaa    720

ggagttacca atcagactgg acttaagcga atagctaaag aaaggcaaaa gcagtataac    780

tgcctgacac agcggattga acgagagaag aaattgttcg ttattgctca gaaaattcaa    840

acacgcaaag atcttatgga taaaactcag aaagtgaagg tgaagaaaga aacggtgaac    900

tccccagcta tttataaatt tcagagtcgt cgaaaacgtt gacgtgttat agataagcct    960

tgtcattctg tatcaaaaat ctgttgtcgt tttctagtaa cttcaaattc cattactcca   1020

aatggcatgg ttttccggtt tgtaaccata actaaattgt cagtctgaca tttaatgtct   1080

ttctatggac aacattaaat ctccctccct tctgtaattg tttttggatt gtgaaattag   1140

tcttattttt atatacttaa tttttttttt ctttgagata gggtctttgt tgccaggctg   1200

gaagtgcagt gtgtgattat ggctcactgc aactttgaac tcctgggctc aagtgatctt   1260

cctgcatcag cctcttgagt agctgggacc acagacatgt gccaccatgt ctgagtaatg   1320

tttaaatttt ctgtagagac caggttttgc catgttggcc aggctggttt tgaactcgtg   1380

gcctcaagcg atcctcccac cttggcctcc caaagggctg ggattacagg gatgagccac   1440

tatgcccagc ccataatttt ttttgttatg aaacatagga tctcattaca gcagatttgg   1500

aaagtagatt aattcattcc taatcccagt gcttattcaa taataacaaa tatttattgc   1560

atgcttaact gtgctaggag ctagagctgt ggaggtggac aattactgtg agtagtctag   1620

ttgatttcct ccattttgta aaacgaggca tcactttttg tccatgtttt tgtgttttat   1680

agttacagta aacaatttga tgtcctactt tttttttttt tttttttgag acggagtctc   1740

gctctgtcgc ccaggccgga ctgcggactg cagtggcgca atctcggctc actgcaagct   1800

ccgcttcccg ggttcacgcc attctcctgc ctcagcctcc cgagtagctg ggactacagg   1860

cgcccgccac cgcgcctggc taattttttt ttgtattttt ttagtagaga cggggtttca   1920

ccttgttagc caggatggtc tcgatctcct gacctcatga tccacccgcc tcggcctccc   1980

aaagtgctgg gattacaggc gtgagccacc gcgcccggcc gatgtcctac tttttaatta   2040

aatcattagc tctttcccag tttgttacat cacaaaagtt ttttacagta atatatgcta   2100

gagtaaacgt taaaataaat attattttta atgattgc                           2138


<210>  6130
<211>  253
<212>  PRT
<213>  Homosapiens

<400>  6130

Met Ala Ala Ala Phe Arg Lys Ala Ala Lys Ser Arg Gln Arg Glu His 
1               5                   10                  15      


Arg Glu Arg Ser Gln Pro Gly Phe Arg Lys His Leu Gly Leu Leu Glu 
            20                  25                  30          


Lys Lys Lys Asp Tyr Lys Leu Arg Ala Asp Asp Tyr Arg Lys Lys Gln 
        35                  40                  45              


Glu Tyr Leu Lys Ala Leu Arg Lys Lys Ala Leu Glu Lys Asn Pro Asp 
    50                  55                  60                  


Glu Phe Tyr Tyr Lys Met Thr Arg Val Lys Leu Gln Asp Gly Val His 
65                  70                  75                  80  


Ile Ile Lys Glu Thr Lys Glu Glu Val Thr Pro Glu Gln Leu Lys Leu 
                85                  90                  95      


Met Arg Thr Gln Asp Val Lys Tyr Ile Glu Met Lys Arg Val Ala Glu 
            100                 105                 110         


Ala Lys Lys Ile Glu Arg Leu Lys Ser Glu Leu His Leu Leu Asp Phe 
        115                 120                 125             


Gln Gly Lys Gln Gln Asn Lys His Val Phe Phe Phe Asp Thr Lys Lys 
    130                 135                 140                 


Glu Val Glu Gln Phe Asp Val Ala Thr His Leu Gln Thr Ala Pro Glu 
145                 150                 155                 160 


Leu Val Asp Arg Val Phe Asn Arg Pro Arg Ile Glu Thr Leu Gln Lys 
                165                 170                 175     


Glu Lys Val Lys Gly Val Thr Asn Gln Thr Gly Leu Lys Arg Ile Ala 
            180                 185                 190         


Lys Glu Arg Gln Lys Gln Tyr Asn Cys Leu Thr Gln Arg Ile Glu Arg 
        195                 200                 205             


Glu Lys Lys Leu Phe Val Ile Ala Gln Lys Ile Gln Thr Arg Lys Asp 
    210                 215                 220                 


Leu Met Asp Lys Thr Gln Lys Val Lys Val Lys Lys Glu Thr Val Asn 
225                 230                 235                 240 


Ser Pro Ala Ile Tyr Lys Phe Gln Ser Arg Arg Lys Arg 
                245                 250             


<210>  6131
<211>  1056
<212>  DNA
<213>  Homosapiens

<400>  6131
agtggacttg gcggcagagg cagtgcggat ccggcgttct ccactgatct tttccaaggc     60

tgtacagaca tggcggcggc ttttcggaag gcggctaagt cccggcagcg ggaacacaga    120

gagcgaagcc agcctggctt tcgaaaacat ctgggcctgc tggagaaaaa gaaagattac    180

aaacttcgtg cagagtgagt tcagtctttc tggtagaggc gctgccaaga aagcttacaa    240

cctccttgca ctgcagctga attgcctgag tgtccaacag gggataattt cctgccattg    300

ataaaatggc caaagctctg gcagcctgtc agataatttt ttctgtgatc ctaaatttct    360

ctctttgttt aggcagatca ttatttattt aactgtagtt gcattgtgaa ttatttgtat    420

tatgttgttc cagatcattt tctcatagtg gctttgattt ggctctgcct tggtgtttga    480

gcccaaagtt gaatcttttt ctctttgttt tcttgaagtg caggatataa tctgaaattc    540

catttgttga gtctcttaca tcaccatgtg tgtgatgtgg aatgaagaga tgtgaaagat    600

ggattcatga gaccaagcgt gggtgataat gaactctgaa aacattttat aaaacaatta    660

tccccattct tgttctctgt tagcactttg tttgcaaaat acttcttaat tatttgttag    720

cgatacatgt cagctgaggt cctttttatg cccctggtct agatggtggt gatggattaa    780

atgggtttct gtaggtccca gagattttaa ggctaatgat aattaagtat tgttattggg    840

ccaggcagtg ttctaggata tttaccgttt ttacactgat ttgtccctcc caacaacctt    900

ctgggatggg ttactattac cgtattcatt ttacaaatga aattgggatt caggatggtt    960

aaataactta tccaaggtta cttagccaga agttgtcaag tccagatttg aacccatgct   1020

gtctggctcc agagtccatg attctagtca ttgcgc                             1056


<210>  6132
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  6132

Met Ala Ala Ala Phe Arg Lys Ala Ala Lys Ser Arg Gln Arg Glu His 
1               5                   10                  15      


Arg Glu Arg Ser Gln Pro Gly Phe Arg Lys His Leu Gly Leu Leu Glu 
            20                  25                  30          


Lys Lys Lys Asp Tyr Lys Leu Arg Ala Glu 
        35                  40          


<210>  6133
<211>  723
<212>  DNA
<213>  Homosapiens

<400>  6133
tggcggcaga ggcagtgcgg atccggcgtt ctccactgat cttttccaag gctgtacaga     60

catggcggcg gcttttcgga aggcggctaa gtcccggcag cgggaacaca gagagcgaag    120

ccagcctggc tttcgaaaac atctgggcct gctggagaaa aagaaagatt acaaacttcg    180

tgcagatgac taccgtaaaa aacaagaata cctcaaagct cttcggaaga aggctcttga    240

aaaaaatcca gatgaattct actacaaaat gactcgggtt aaactccagg atggagtaca    300

tattattaag gagactaagg aagaattacc aatcagactg gacttaagcg aatagctaaa    360

gaaaggcaaa agcagtataa ctgcctgaca cagcggattg aacgagagaa gaaattgttc    420

gttattgctc agaaaattca aacacgcaaa gatcttatgg ataaaactca gaaagtgaag    480

gtgaagaaag aaacggtgaa ctccccagct atttataaat ttcagagtcg tcgaaaacgt    540

tgacgtgtta tagataagcc ttgtcattct gtatcaaaaa tctgttgtcg ttttctagta    600

acttcaaatt ccattactcc aaatggcatg gttttccggt ttgtaaccat aactaaattg    660

tcagtctgac atttaatgtc tttctatgga caacattaaa tctccctccc ttctgtaatt    720

gtt                                                                  723


<210>  6134
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  6134

Met Ala Ala Ala Phe Arg Lys Ala Ala Lys Ser Arg Gln Arg Glu His 
1               5                   10                  15      


Arg Glu Arg Ser Gln Pro Gly Phe Arg Lys His Leu Gly Leu Leu Glu 
            20                  25                  30          


Lys Lys Lys Asp Tyr Lys Leu Arg Ala Asp Asp Tyr Arg Lys Lys Gln 
        35                  40                  45              


Glu Tyr Leu Lys Ala Leu Arg Lys Lys Ala Leu Glu Lys Asn Pro Asp 
    50                  55                  60                  


Glu Phe Tyr Tyr Lys Met Thr Arg Val Lys Leu Gln Asp Gly Val His 
65                  70                  75                  80  


Ile Ile Lys Glu Thr Lys Glu Glu Leu Pro Ile Arg Leu Asp Leu Ser 
                85                  90                  95      


Glu 
    


<210>  6135
<211>  1913
<212>  DNA
<213>  Homosapiens

<400>  6135
ttctctcttt gtttaggcag atcattattt atttaactgt agttgcattg tgaattattt     60

gtattatgtt gttccagatc attttctcat agtggctttg atttggctct gccttggtgt    120

ttgagcccaa agttgaatct ttttctcttt gttttcttga agtgcaggat ataatctgaa    180

attccatttg ttgagtctct tacatcacca tgtgtgtgat gtggaatgaa gagatgtgaa    240

agatggattc atgagaccaa gcgtgggtga taatgaactc tgaaaacatt ttataaaaca    300

attatcccca ttcttgttct ctgttagcac tttgtttgca aaatacttct taattatttg    360

ttagcgatac atgtcagctg aggtcctttt tatgcccctg gtctagatgg tggtgatgga    420

ttaaatgggt ttctgtaggt cccagagatt ttaaggctaa tgataattaa gtattgttat    480

tgggccaggc agtgttctag gatatttacc gtttttacac tgatttgtcc ctcccaacaa    540

ccttctggga tgggttacta ttaccgtatt cattttacaa atgaaattgg gattcaggat    600

ggttaaataa cttatccaag gttacttagc cagaagttgt caagtccaga tttgaaccca    660

tgctgtctgg ctccagagtc catgattcta gtcattgcgc tatactgtac tgtgtagttt    720

ctgaattaca tatggtcatt tggtgcccaa gcttgcacca tatcctaagg agttttaatt    780

tgtactttgt ttggtgtctc cctgtaatga tataaatggc actgaaacat atataggctg    840

gggacagtta atttcaggtt ccactggaat aggaactgtt gattagactg tggaccctgc    900

gaagacatga gctcagctca gtgacagtgg agtgtccaga tccagtcagt gcttttggct    960

tttttgagtt tcactctgtg tgacctttta gatgcttgta aagtttgctt attgtgggtt   1020

tttggttttt taaaattatc tatttttttt tttttgctat gaacctcatt taacctgtct   1080

tttagtgact accgtaaaaa acaagaatac ctcaaagctc ttcggaagaa ggctcttgaa   1140

aaaaatccag atgaattcta ctacaaaatg actcgggtta aactccagga tggagtacat   1200

attattaagg agactaagga agaagtaacc ccagaacaac taaagctgat gagaactcag   1260

gacgtcaaat atatagaaat gaagagggtt gcagaagcta agaaaatcga aagactaaaa   1320

tcagagctcc atctgctgga tttccagggg aagcaacaga acaagcatgt gttctttttt   1380

gacaccaaaa aggaagttga acagtttgat gtcgcaactc acctgcaaac agccccggag   1440

ctagtcgaca gagtctttaa taggcccagg atagagacct tgcagaaaga aaaagtgaaa   1500

ggagttacca atcagactgg acttaagcga atagctaaag aaaggcaaaa gcagtataac   1560

tgcctgacac agcggattga acgagagaag aaattgttcg ttattgctca gaaaattcaa   1620

acacgcaaag atcttatgga taaaactcag aaagtgaagg tgaagaaaga aacggtgaac   1680

tccccagcta tttataaatt tcagagtcgt cgaaaacgtt gacgtgttat agataagcct   1740

tgtcattctg tatcaaaaat ctgttgtcgt tttctagtaa cttcaaattc cattactcca   1800

aatggcatgg ttttccggtt tgtaaccata actaaattgt cagtctgaca tttaatgtct   1860

ttctatggac aacattaaat ctccctccct tctgtaattg tttttggatt gtg          1913


<210>  6136
<211>  184
<212>  PRT
<213>  Homosapiens

<400>  6136

Met Thr Arg Val Lys Leu Gln Asp Gly Val His Ile Ile Lys Glu Thr 
1               5                   10                  15      


Lys Glu Glu Val Thr Pro Glu Gln Leu Lys Leu Met Arg Thr Gln Asp 
            20                  25                  30          


Val Lys Tyr Ile Glu Met Lys Arg Val Ala Glu Ala Lys Lys Ile Glu 
        35                  40                  45              


Arg Leu Lys Ser Glu Leu His Leu Leu Asp Phe Gln Gly Lys Gln Gln 
    50                  55                  60                  


Asn Lys His Val Phe Phe Phe Asp Thr Lys Lys Glu Val Glu Gln Phe 
65                  70                  75                  80  


Asp Val Ala Thr His Leu Gln Thr Ala Pro Glu Leu Val Asp Arg Val 
                85                  90                  95      


Phe Asn Arg Pro Arg Ile Glu Thr Leu Gln Lys Glu Lys Val Lys Gly 
            100                 105                 110         


Val Thr Asn Gln Thr Gly Leu Lys Arg Ile Ala Lys Glu Arg Gln Lys 
        115                 120                 125             


Gln Tyr Asn Cys Leu Thr Gln Arg Ile Glu Arg Glu Lys Lys Leu Phe 
    130                 135                 140                 


Val Ile Ala Gln Lys Ile Gln Thr Arg Lys Asp Leu Met Asp Lys Thr 
145                 150                 155                 160 


Gln Lys Val Lys Val Lys Lys Glu Thr Val Asn Ser Pro Ala Ile Tyr 
                165                 170                 175     


Lys Phe Gln Ser Arg Arg Lys Arg 
            180                 


<210>  6137
<211>  2918
<212>  DNA
<213>  Homosapiens

<400>  6137
ttctctcttt gtttaggcag atcattattt atttaactgt agttgcattg tgaattattt     60

gtattatgtt gttccagatc attttctcat agtggctttg atttggctct gccttggtgt    120

ttgagcccaa agttgaatct ttttctcttt gttttcttga agtgcaggat ataatctgaa    180

attccatttg ttgagtctct tacatcacca tgtgtgtgat gtggaatgaa gagatgtgaa    240

agatggattc atgagaccaa gcgtgggtga taatgaactc tgaaaacatt ttataaaaca    300

attatcccca ttcttgttct ctgttagcac tttgtttgca aaatacttct taattatttg    360

ttagcgatac atgtcagctg aggtcctttt tatgcccctg gtctagatgg tggtgatgga    420

ttaaatgggt ttctgtaggt cccagagatt ttaaggctaa tgataattaa gtattgttat    480

tgggccaggc agtgttctag gatatttacc gtttttacac tgatttgtcc ctcccaacaa    540

ccttctggga tgggttacta ttaccgtatt cattttacaa atgaaattgg gattcaggat    600

ggttaaataa cttatccaag gttacttagc cagaagttgt caagtccaga tttgaaccca    660

tgctgtctgg ctccagagtc catgattcta gtcattgcgc tatactgtac tgtgtagttt    720

ctgaattaca tatggtcatt tggtgcccaa gcttgcacca tatcctaagg agttttaatt    780

tgtactttgt ttggtgtctc cctgtaatga tataaatggc actgaaacat atataggctg    840

gggacagtta atttcaggtt ccactggaat aggaactgtt gattagactg tggaccctgc    900

gaagacatga gctcagctca gtgacagtgg agtgtccaga tccagtcagt gcttttggct    960

tttttgagtt tcactctgtg tgacctttta gatgcttgta aagtttgctt attgtgggtt   1020

tttggttttt taaaattatc tatttttttt tttttgctat gaacctcatt taacctgtct   1080

tttagtgact accgtaaaaa acaagaatac ctcaaagctc ttcggaagaa ggctcttgaa   1140

aaaaatccag atgaattcta ctacaaaatg actcgggtta aactccagga tggagtacat   1200

attattaagg agactaagga agaagtaacc ccagaacaac taaagctgat gagaactcag   1260

gacgtcaaat atatagaaat gaagagggtt gcagaagcta agaaaatcga aagactaaaa   1320

tcagagctcc atctgctgga tttccagggg aagcaacaga acaagcatgt gttctttttt   1380

gacaccaaaa aggaagttga acagtttgat gtcgcaactc acctgcaaac agccccggag   1440

ctagtcgaca gagtctttaa taggcccagg atagagacct tgcagaaaga aaaagtgaaa   1500

ggagttacca atcagactgg acttaagcga atagctaaag aaaggcaaaa gcagtataac   1560

tgcctgacac agcggattga acgagagaag aaattgttcg ttattgctca gaaaattcaa   1620

acacgcaaag atcttatgga taaaactcag aaagtgaagg tgaagaaaga aacggtgaac   1680

tccccagcta tttataaatt tcagagtcgt cgaaaacgtt gacgtgttat agataagcct   1740

tgtcattctg tatcaaaaat ctgttgtcgt tttctagtaa cttcaaattc cattactcca   1800

aatggcatgg ttttccggtt tgtaaccata actaaattgt cagtctgaca tttaatgtct   1860

ttctatggac aacattaaat ctccctccct tctgtaattg tttttggatt gtgaaattag   1920

tcttattttt atatacttaa tttttttttt ctttgagata gggtctttgt tgccaggctg   1980

gaagtgcagt gtgtgattat ggctcactgc aactttgaac tcctgggctc aagtgatctt   2040

cctgcatcag cctcttgagt agctgggacc acagacatgt gccaccatgt ctgagtaatg   2100

tttaaatttt ctgtagagac caggttttgc catgttggcc aggctggttt tgaactcgtg   2160

gcctcaagcg atcctcccac cttggcctcc caaagggctg ggattacagg gatgagccac   2220

tatgcccagc ccataatttt ttttgttatg aaacatagga tctcattaca gcagatttgg   2280

aaagtagatt aattcattcc taatcccagt gcttattcaa taataacaaa tatttattgc   2340

atgcttaact gtgctaggag ctagagctgt ggaggtggac aattactgtg agtagtctag   2400

ttgatttcct ccattttgta aaacgaggca tcactttttg tccatgtttt tgtgttttat   2460

agttacagta aacaatttga tgtcctactt tttttttttt tttttttgag acggagtctc   2520

gctctgtcgc ccaggccgga ctgcggactg cagtggcgca atctcggctc actgcaagct   2580

ccgcttcccg ggttcacgcc attctcctgc ctcagcctcc cgagtagctg ggactacagg   2640

cgcccgccac cgcgcctggc taattttttt ttgtattttt ttagtagaga cggggtttca   2700

ccttgttagc caggatggtc tcgatctcct gacctcatga tccacccgcc tcggcctccc   2760

aaagtgctgg gattacaggc gtgagccacc gcgcccggcc gatgtcctac tttttaatta   2820

aatcattagc tctttcccag tttgttacat cacaaaagtt ttttacagta atatatgcta   2880

gagtaaacgt taaaataaat attattttta atgattgc                           2918


<210>  6138
<211>  184
<212>  PRT
<213>  Homosapiens

<400>  6138

Met Thr Arg Val Lys Leu Gln Asp Gly Val His Ile Ile Lys Glu Thr 
1               5                   10                  15      


Lys Glu Glu Val Thr Pro Glu Gln Leu Lys Leu Met Arg Thr Gln Asp 
            20                  25                  30          


Val Lys Tyr Ile Glu Met Lys Arg Val Ala Glu Ala Lys Lys Ile Glu 
        35                  40                  45              


Arg Leu Lys Ser Glu Leu His Leu Leu Asp Phe Gln Gly Lys Gln Gln 
    50                  55                  60                  


Asn Lys His Val Phe Phe Phe Asp Thr Lys Lys Glu Val Glu Gln Phe 
65                  70                  75                  80  


Asp Val Ala Thr His Leu Gln Thr Ala Pro Glu Leu Val Asp Arg Val 
                85                  90                  95      


Phe Asn Arg Pro Arg Ile Glu Thr Leu Gln Lys Glu Lys Val Lys Gly 
            100                 105                 110         


Val Thr Asn Gln Thr Gly Leu Lys Arg Ile Ala Lys Glu Arg Gln Lys 
        115                 120                 125             


Gln Tyr Asn Cys Leu Thr Gln Arg Ile Glu Arg Glu Lys Lys Leu Phe 
    130                 135                 140                 


Val Ile Ala Gln Lys Ile Gln Thr Arg Lys Asp Leu Met Asp Lys Thr 
145                 150                 155                 160 


Gln Lys Val Lys Val Lys Lys Glu Thr Val Asn Ser Pro Ala Ile Tyr 
                165                 170                 175     


Lys Phe Gln Ser Arg Arg Lys Arg 
            180                 


<210>  6139
<211>  790
<212>  DNA
<213>  Homosapiens

<400>  6139
gcttttgccg cctgtaccct tcctggagca acccgtgctt ttgaaaaatg accatgccga     60

aggggaacta acactcccag cctggtgcgg gtcttgtcaa tctgattttt aaatgatgga    120

ggaggaggtt tgaggacaaa gctcatggtg gcattaccac tatcagggac gctgcaaaga    180

tcaagtgaaa aggggaaaag gctcttctca atgtgagcac attcacaggc tctgagaaca    240

gagaggtatt taaagtgaac tggaacaaac ctgcaacatc cggtgcgttc tgccttcaaa    300

aatagctgcc agttagaaag ggttatttac atattgattt catgctaact ttgtaatgga    360

atgtgctgcc tgcctgcctg cctgagacct aacaactgtc atcataattt tttctaaaaa    420

tacagtcaga gaaaaacact cattgaaccc tccactggaa agtagctgca aaagaccccc    480

tgatcccaaa cctgcttgac agaccacagc caagggcagg gacactcaac aactgtaaac    540

gaggaacatt tcacagcggc agctggcccc tctcttcttc caaccagcca atattttttg    600

tctttctaga aaacctgtct tgttcaaagg cctgatggag ctgattcggt tgtgatcctg    660

ggcatatgga tggcatattt gctgcgagct agccggcccc cgctgctgcg gacaaatctt    720

tcattcatga acaggagctt gttaggccaa ctccggactc taaagccact taattaaatt    780

gtggaaagtc                                                           790


<210>  6140
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  6140

Met Ala Tyr Leu Leu Arg Ala Ser Arg Pro Pro Leu Leu Arg Thr Asn 
1               5                   10                  15      


Leu Ser Phe Met Asn Arg Ser Leu Leu Gly Gln Leu Arg Thr Leu Lys 
            20                  25                  30          


Pro Leu Asn 
        35  


<210>  6141
<211>  3643
<212>  DNA
<213>  Homosapiens

<400>  6141
tttaatgaac ttcagttcct accttttttt tttttttttt tgagataggg tctctgttgc     60

ccaagctgga gtgcagtagt gaacacagct cactgcagcc tcgacctcct gggctcaagc    120

tgtcctcctt cagcctcctg tgtagccagg agcacaggcg tgtgccactg cacctggcta    180

acttttggat atttttgtag agatggagtc tcactttgtt gcccagactg gttttgaact    240

ccagggctaa agtgatcctc cttggcctcc caaagtgttg ggattacagg tgtatgccat    300

gtgcctggcc tctgtatctt ttcaatgggc atagtcctct tgtatttatg tagtttactt    360

tcgcttgttg cagaaaggac ataatgtggt taaatagggc tatagtaata attcgtgtcc    420

tcagggttgt tgtgaggatc aaagaaatgt atgagaaggt aaactgcaag gttcagaata    480

gtaaaaataa gcccccactt catgaaaaaa aaaatacacg gaaaatatag agaaatgaaa    540

ataggagtaa agagccacta ctcaagtcaa ccactaacaa ctgttttagt gttatttctg    600

tcaccttaaa attgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttcttgtg ttgcctaggc    660

tggtcttgaa ttccaaagct caagcattcc tcccacctca gccttccaaa gtgctgggat    720

tacaggcatg ggccaccatg ccagacccca aatttttttt gacattatgc ttatgctacc    780

atatgagaac acaaattgta aggcttggaa tagtttaaaa agtaaacctc acccctattc    840

attaaaaact gcatggaaaa tatagaaaag tgaaaatagg agaaaaaaga tacattgttt    900

tactgccaaa gaaaattacc agttactcct gacattttct tttccttttt ttcttttttt    960

tccctgagac agagtcttgc tctgtcactc aggctggagt gcagtggcac agtctcagtt   1020

cactgcaacc tctgcctctt gggttcaagc gattctcctg ccttagcctc ccgagtagct   1080

gggactacag gtgtgagcca ccatgcccgg ctacttttta ttttttattt tttagtagag   1140

atggggcttc accatgtcgg ccaggctggt ctcgaactcc tgacctcaag acaggtggcc   1200

cgcctcaacc tcccaaagtg ctgggattac aagtgtgagc cattgcaccc agccgacatt   1260

ttctttttag tatatttccc tcaccttttc tgtttttgaa ggcaaatact tttaaaaaag   1320

catttttaat aactcttaat tcgtaacaat agctagataa cctttagatt tttataggca   1380

agtacatcag aaaagactct tgagtccgta tctcttttta aaagttgttg atttcaacat   1440

agtccctgct agtctctagc tgagactgtt cttgtttagt ctaagtattt tcttgctttt   1500

gtgaggaagc aaaaaatatg ttttctgtga aaatgtgatt gacctggcaa atagaatatg   1560

cctcgaagga gctcatctaa gtgaggcggc aggtcccaga ggtccctgtt accttagggc   1620

agtaaagaga ggagacacct cagctgggtt tacagaacac agtctagggg gtgagtagcc   1680

ccacctggtg agatgttggt aacgttgtca tttccctggt taagatatac atatgtttgc   1740

acctttttct ccaaatgtct gattatctat attaaaggat gtgtatggag ttgttgtttt   1800

taataggtat ccctgaaatt ctgtgtttag gaacactata ccttaacaac actctctccc   1860

aatatgttta agccagtatt ctttcccaga gacatttggg aaactgggtg gatgtcattg   1920

tgcagattaa atgtggcaga tgcctagatg ggaaacctgt aatgaatagt actttctttt   1980

aaaataggtt aaaggaagat ggaagtggaa gtgcttatga caaagaatct atggcaatta   2040

tcaagctgaa taatacaact gtcctttatt taaaggaggt gactaaattt ttggcactgg   2100

tctgcattct aagggaagaa agctttgaaa gaaaaggttt aatagactac aacttccact   2160

gtttccgaaa agctattcat gaggtttttg aggtgggtgt gacttctcac aggagctgtg   2220

gtcaccagac tagtgcctcc agtctgaaag cgctgacaca caatggcacg ccacgaaacg   2280

ccatctagtc tgaatcccag cgtcggggct ctgtgccagc ttactcttca ctccagggtc   2340

ggatgccacg tgctacagga catgggagct gctgcttgtg ggaatctggt gcctgttcca   2400

ctagagacaa ggggtagagt ttctcatttg gatgaaaacc ccttcaactg gtggtgtaca   2460

actgaagcta ctatatcttt tttgaaaatg gcaaaaaaaa aaaaaaaaaa ttctggagac   2520

cacagaactc aagtgtgtgt ttctcctctt ttgggtcccc tttaagtagt tgggatattt   2580

tggacctgga gataacacca gttacccatc cttaccaggg aatgttgcca tcaattccag   2640

ttgaaaataa tagaaaagac tgaattttta tatgcttcac ttaggctttc atttgagtag   2700

actctaaaaa ttctgccttg cttaagttct aacactgcct ctcagatttc agttttggac   2760

attgcacaac taagaccttt taaatgcatt tgcttgctaa ctcggaagac acatagtctg   2820

cagcaagaca ttcctatatt gaagaaatga gagaaaattt tatgctgcat caggtggaga   2880

gcaaggctca acggtggttg cattagttcc ctcggaagta ttgaaaaaac tttgaaatgg   2940

aagaaaattt ttgcacctat gttctgagta ccagatgtct gggttctttc ttctgcatta   3000

gataaatgat catgctcagt gtaacaaagg gaattaaaag ttttcccaca gtccccttct   3060

aggggagaaa ctcattgtgt cactgaaatg tttagcttac tttaatcttg atatcagcct   3120

ctacagacct tttattctaa gctatcgagc ttcttgattg catttggttg accacgagtg   3180

accctaaggc attgggggac tgtccactgg gagttggagt gagcacgtgg tgctgcaaca   3240

ggcattgttt tacatacttt gtctctagta ttctgacacc aagtgtcaac tgtggtactt   3300

tctttgccta ggatatgaat tcataattgt tgcttttgtt gatggttgat accctttcca   3360

ttgatttaaa cctaacacat tatttctatt ccacatgccc agtagacata tattccaaag   3420

ccactggacc acttgagtac ataagtgcca ctgtttaatg caatatgtat attcaggtct   3480

gtaaagctaa cagtgtgact tggagtgctt cctgcaggtg attctgactt gagtatttac   3540

atggaccatg gtgatatcca aaagaaaaat gctttttata tttatagatt atttcattga   3600

actatatatg aaatgggtat caataaatgt atttactcca aaa                     3643


<210>  6142
<211>  85
<212>  PRT
<213>  Homosapiens

<400>  6142

Met Ala Ile Ile Lys Leu Asn Asn Thr Thr Val Leu Tyr Leu Lys Glu 
1               5                   10                  15      


Val Thr Lys Phe Leu Ala Leu Val Cys Ile Leu Arg Glu Glu Ser Phe 
            20                  25                  30          


Glu Arg Lys Gly Leu Ile Asp Tyr Asn Phe His Cys Phe Arg Lys Ala 
        35                  40                  45              


Ile His Glu Val Phe Glu Val Gly Val Thr Ser His Arg Ser Cys Gly 
    50                  55                  60                  


His Gln Thr Ser Ala Ser Ser Leu Lys Ala Leu Thr His Asn Gly Thr 
65                  70                  75                  80  


Pro Arg Asn Ala Ile 
                85  


<210>  6143
<211>  2728
<212>  DNA
<213>  Homosapiens

<400>  6143
gggcttcggc tcggggccta tgagagccgg gctccggggg gcgggccgga ctgtggcggc     60

tgccgggggc ggtggcggtg gtggcggcgg cggcggaggc ggactgggga ggcggcggcc    120

tggctcggcc tggcctggcc tgtcagggcg cgggcggcgg cggctccagc accatgtccc    180

tgcagtacgg ggcggaggag acgcccctcg ccggcagtta cggcgcggcc gattcgtttc    240

caaaggactt cggctacggc gtggaggagg aggaagagga ggcggcggcg gcgggcggag    300

gggttggggc aggggcaggc ggtggctgtg gtccgggggg cgctgacagc tccaagccga    360

ggattctgct catgggactc cggcgcagcg gcaagtcctc catccagaag gtggtgtttc    420

ataagatgtc acccaacgag accctctttt tggaaagtac caacaagatt tataaggatg    480

acatttccaa tagctccttt gtgaatttcc agatatggga ttttcctggg caaatggact    540

tttttgaccc aacctttgac tatgagatga tcttcagggg aacaggagca ttgatatacg    600

tcattgacgc acaggatgac tacatggagg ctttaacaag acttcacatt actgtttcta    660

aagcctacaa agttaaccca gacatgaatt ttgaggtttt tattcacaaa gttgatggtc    720

tgtctgatga tcacaaaata gaaacacaga gggacattca tcaaagggcc aatgatgacc    780

ttgcagatgc tgggctagaa aaactccatc ttagctttta tctgactagt atctatgacc    840

attcaatatt tgaagccttt agtaaggtgg tgcagaaact cattccacaa ctgccgacct    900

tggaaaacct attaaatatc tttatatcaa attcaggtat tgaaaaagct tttctctttg    960

atgttgtcag caaaatctac attgcaacag acagttcccc tgtggatatg caatcttatg   1020

aactttgctg tgacatgatc gatgttgtaa ttgatgtgtc ttgtatatat gggttaaagg   1080

aagatggaag tggaagtgct tatgacaaag aatctatggc aattatcaag ctgaataata   1140

caactgtcct ttatttaaag gaggtgacta aatttttggc actggtctgc attctaaggg   1200

aagaaagctt tgaaagaaaa ggtttaatag actacaactt ccactgtttc cgaaaagcta   1260

ttcatgaggt ttttgaggtg ggtgtgactt ctcacaggag ctgtggtcac cagactagtg   1320

cctccagtct gaaagcgctg acacacaatg gcacgccacg aaacgccatc tagtctgaat   1380

cccagcgtcg gggctctgtg ccagcttact cttcactcca gggtcggatg ccacgtgcta   1440

caggacatgg gagctgctgc ttgtgggaat ctggtgcctg ttccactaga gacaaggggt   1500

agagtttctc atttggatga aaaccccttc aactggtggt gtacaactga agctactata   1560

tcttttttga aaatggcaaa aaaaaaaaaa aaaaattctg gagaccacag aactcaagtg   1620

tgtgtttctc ctcttttggg tcccctttaa gtagttggga tattttggac ctggagataa   1680

caccagttac ccatccttac cagggaatgt tgccatcaat tccagttgaa aataatagaa   1740

aagactgaat ttttatatgc ttcacttagg ctttcatttg agtagactct aaaaattctg   1800

ccttgcttaa gttctaacac tgcctctcag atttcagttt tggacattgc acaactaaga   1860

ccttttaaat gcatttgctt gctaactcgg aagacacata gtctgcagca agacattcct   1920

atattgaaga aatgagagaa aattttatgc tgcatcaggt ggagagcaag gctcaacggt   1980

ggttgcatta gttccctcgg aagtattgaa aaaactttga aatggaagaa aatttttgca   2040

cctatgttct gagtaccaga tgtctgggtt ctttcttctg cattagataa atgatcatgc   2100

tcagtgtaac aaagggaatt aaaagttttc ccacagtccc cttctagggg agaaactcat   2160

tgtgtcactg aaatgtttag cttactttaa tcttgatatc agcctctaca gaccttttat   2220

tctaagctat cgagcttctt gattgcattt ggttgaccac gagtgaccct aaggcattgg   2280

gggactgtcc actgggagtt ggagtgagca cgtggtgctg caacaggcat tgttttacat   2340

actttgtctc tagtattctg acaccaagtg tcaactgtgg tactttcttt gcctaggata   2400

tgaattcata attgttgctt ttgttgatgg ttgataccct ttccattgat ttaaacctaa   2460

cacattattt ctattccaca tgcccagtag acatatattc caaagccact ggaccacttg   2520

agtacataag tgccactgtt taatgcaata tgtatattca ggtctgtaaa gctaacagtg   2580

tgacttggag tgcttcctgc aggtgattct gacttgagta tttacatgga ccatggtgat   2640

atccaaaaga aaaatgcttt ttatatttat agattatttc attgaactat atatgaaatg   2700

ggtatcaata aatgtattta ctccaaaa                                      2728


<210>  6144
<211>  399
<212>  PRT
<213>  Homosapiens

<400>  6144

Met Ser Leu Gln Tyr Gly Ala Glu Glu Thr Pro Leu Ala Gly Ser Tyr 
1               5                   10                  15      


Gly Ala Ala Asp Ser Phe Pro Lys Asp Phe Gly Tyr Gly Val Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Ala Ala Ala Ala Gly Gly Gly Val Gly Ala Gly Ala 
        35                  40                  45              


Gly Gly Gly Cys Gly Pro Gly Gly Ala Asp Ser Ser Lys Pro Arg Ile 
    50                  55                  60                  


Leu Leu Met Gly Leu Arg Arg Ser Gly Lys Ser Ser Ile Gln Lys Val 
65                  70                  75                  80  


Val Phe His Lys Met Ser Pro Asn Glu Thr Leu Phe Leu Glu Ser Thr 
                85                  90                  95      


Asn Lys Ile Tyr Lys Asp Asp Ile Ser Asn Ser Ser Phe Val Asn Phe 
            100                 105                 110         


Gln Ile Trp Asp Phe Pro Gly Gln Met Asp Phe Phe Asp Pro Thr Phe 
        115                 120                 125             


Asp Tyr Glu Met Ile Phe Arg Gly Thr Gly Ala Leu Ile Tyr Val Ile 
    130                 135                 140                 


Asp Ala Gln Asp Asp Tyr Met Glu Ala Leu Thr Arg Leu His Ile Thr 
145                 150                 155                 160 


Val Ser Lys Ala Tyr Lys Val Asn Pro Asp Met Asn Phe Glu Val Phe 
                165                 170                 175     


Ile His Lys Val Asp Gly Leu Ser Asp Asp His Lys Ile Glu Thr Gln 
            180                 185                 190         


Arg Asp Ile His Gln Arg Ala Asn Asp Asp Leu Ala Asp Ala Gly Leu 
        195                 200                 205             


Glu Lys Leu His Leu Ser Phe Tyr Leu Thr Ser Ile Tyr Asp His Ser 
    210                 215                 220                 


Ile Phe Glu Ala Phe Ser Lys Val Val Gln Lys Leu Ile Pro Gln Leu 
225                 230                 235                 240 


Pro Thr Leu Glu Asn Leu Leu Asn Ile Phe Ile Ser Asn Ser Gly Ile 
                245                 250                 255     


Glu Lys Ala Phe Leu Phe Asp Val Val Ser Lys Ile Tyr Ile Ala Thr 
            260                 265                 270         


Asp Ser Ser Pro Val Asp Met Gln Ser Tyr Glu Leu Cys Cys Asp Met 
        275                 280                 285             


Ile Asp Val Val Ile Asp Val Ser Cys Ile Tyr Gly Leu Lys Glu Asp 
    290                 295                 300                 


Gly Ser Gly Ser Ala Tyr Asp Lys Glu Ser Met Ala Ile Ile Lys Leu 
305                 310                 315                 320 


Asn Asn Thr Thr Val Leu Tyr Leu Lys Glu Val Thr Lys Phe Leu Ala 
                325                 330                 335     


Leu Val Cys Ile Leu Arg Glu Glu Ser Phe Glu Arg Lys Gly Leu Ile 
            340                 345                 350         


Asp Tyr Asn Phe His Cys Phe Arg Lys Ala Ile His Glu Val Phe Glu 
        355                 360                 365             


Val Gly Val Thr Ser His Arg Ser Cys Gly His Gln Thr Ser Ala Ser 
    370                 375                 380                 


Ser Leu Lys Ala Leu Thr His Asn Gly Thr Pro Arg Asn Ala Ile 
385                 390                 395                 


<210>  6145
<211>  1226
<212>  DNA
<213>  Homosapiens

<400>  6145
ccccctgtgt aaatgcagta aagagatgaa gccaggtggg aaagtgtatt tgtcatcttg     60

agtgatgggt atggtagaca agataaagag gctttattga actcactgaa atcaaatgtt    120

aagaaactta aaattttatg tattataata gttgtcatag aacataaggt atttttcaaa    180

ttaatcaagc tatgttgtgt ttttcagctt ttatctgact agtatctatg accattcaat    240

atttgaagcc tttagtaagg tggtgcagaa actcattcca caactgccga ccttggaaaa    300

cctattaaat atctttatat caaattcagg tattgaaaaa gcttttctct ttgatgttgt    360

cagcaaaatc tacattgcaa cagacagttc ccctgtggat atgcaatctt atgaactttg    420

ctgtgacatg atcgatgttg taattgatgt gtcttgtata tatgggtaag ttatgtatat    480

attcctgcaa tatctcagac aggcggaaaa ctattaactt gatttgttca gaagactaat    540

ttctgaggcc cctggcaagt ggtactacat gaactgggat tgttctgacc atagtgcttt    600

aacttggagc atgatttctc tggaagttgg ctgctgggtc ttactccttc ggagaatggc    660

taagaaaagt tggaaagcat gactagaact ggacttgttt atcactgcaa gtttctccca    720

ctgttgtggg gatgggggag ggttgcactg tgtcttctca ctactggaac ttagttagat    780

tgaaaaacta gattaattta aaatggtctg aataacaaag taagttctgg ttcctgattt    840

aacctcaggc tttgtggaat tagggattct taatctttca gagagcaaag aaagtaatta    900

gaattttgga tgttggaaga acttataaaa atctgaccca tatatacaag tttccaaaat    960

aaatctctaa aatttgagct cctcctttat gtaaatttgc caaactcgct atagaaattt   1020

atgaaagcca gccagcaagt gattttgtag aataggccag aggactggtg aaaactttgg   1080

agaattactg gcttttcaaa agctgataat ggccaggtgt ggtggcttgt gcccataatc   1140

ccagatgttt ggaagcctgg ggtgagagga tcgcttgggg ccaggagttg gagaccagtc   1200

tgggcaacat agacctcagc tttacc                                        1226


<210>  6146
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  6146

Met Asn Trp Asp Cys Ser Asp His Ser Ala Leu Thr Trp Ser Met Ile 
1               5                   10                  15      


Ser Leu Glu Val Gly Cys Trp Val Leu Leu Leu Arg Arg Met Ala Lys 
            20                  25                  30          


Lys Ser Trp Lys Ala 
        35          


<210>  6147
<211>  630
<212>  DNA
<213>  Homosapiens

<400>  6147
aacgctgtct gcaccgctcc cctgccttct tccgggctcc cagagcaccg ctatggagat     60

gctctcccgg catttgagga agaattgatt gtcctcatcc tgcaactgta cttgcccaac    120

cgatatttat tgatgcctgc agtgtcctgg gtgcctacca aggggcacag aactggatcc    180

gacgcagacc ctgcctgcct tcaggttgct tgaagatgaa cagagagatc ggacctctgc    240

atgaagccag actgctcatc attccagaca tcttcagctg ctacacccag aacaagcatt    300

cgaaatatga acaggatgag cactctctat gttgcccagg ctggtctcag actcctggac    360

tcaaagcgat cctccttcgt cagcctccca agtagctggg actgcagatt catgctctcc    420

atctccagat catgaacagc agccattgtc ctgggtcctc cctcctcccc agaaggacat    480

gaatcccagg gaacagcagg tggccctagg tcctcaggct gccgctcttc cctgggctgt    540

ctggcgcaac gactgctttc caaggccttt cctgtatgtg aagagaagac agctgaagat    600

gatcaaaatg atctaaacct cctaaatggc                                     630


<210>  6148
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  6148

Met Leu Pro Arg Leu Val Ser Asp Ser Trp Thr Gln Ser Asp Pro Pro 
1               5                   10                  15      


Ser Ser Ala Ser Gln Val Ala Gly Thr Ala Asp Ser Cys Ser Pro Ser 
            20                  25                  30          


Pro Asp His Glu Gln Gln Pro Leu Ser Trp Val Leu Pro Pro Pro Gln 
        35                  40                  45              


Lys Asp Met Asn Pro Arg Glu Gln Gln Val Ala Leu Gly Pro Gln Ala 
    50                  55                  60                  


Ala Ala Leu Pro Trp Ala Val Trp Arg Asn Asp Cys Phe Pro Arg Pro 
65                  70                  75                  80  


Phe Leu Tyr Val Lys Arg Arg Gln Leu Lys Met Ile Lys Met Ile 
                85                  90                  95  


<210>  6149
<211>  441
<212>  DNA
<213>  Homosapiens

<400>  6149
attgattgtc ctcatcctgc aactgtactt gcccaaccga tatttattga tgcctgcagt     60

gtcctgggtg cctaccaagg ggcacagaac tggatccgac gcagaccctg cctgccttca    120

ggttgcttga agatgaacag agagatcgga cctctgcatg aagccagact gctcatcatt    180

ccagacatct tcagctgcta cacccagaac aagcattcga aatatgaaca ggatggtgag    240

ccagatcttt ccaatcatgg tggagtggat gtgaacttcc tccagagtat ctccaaggag    300

attccagtcc cccatgttta tttagtcagc catcttagct ctgatccaca tcaaataaga    360

ggcagataaa ttcttccatt ctgaagggag cactatttct taaagcaaac ctatggtgaa    420

aatataacaa tatgtcactt c                                              441


<210>  6150
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  6150

Met Asn Arg Glu Ile Gly Pro Leu His Glu Ala Arg Leu Leu Ile Ile 
1               5                   10                  15      


Pro Asp Ile Phe Ser Cys Tyr Thr Gln Asn Lys His Ser Lys Tyr Glu 
            20                  25                  30          


Gln Asp Gly Glu Pro Asp Leu Ser Asn His Gly Gly Val Asp Val Asn 
        35                  40                  45              


Phe Leu Gln Ser Ile Ser Lys Glu Ile Pro Val Pro His Val Tyr Leu 
    50                  55                  60                  


Val Ser His Leu Ser Ser Asp Pro His Gln Ile Arg Gly Arg 
65                  70                  75              


<210>  6151
<211>  1965
<212>  DNA
<213>  Homosapiens

<400>  6151
ctatgaagta gctgagtgag cctaatcccc aaatgttggt agccttatat gaagaaccag     60

agaaacctaa cagtgctttg gattttttaa agcatcactt aggagctgct actccagaaa    120

atccagaaat agagctgctt cgcctagaac tggccgaaat gaaagagaag tatgaagcta    180

ttgtagaaga aaataaaaaa ctgaaagcaa agcttgctca gtatgaacca cctcaggagg    240

agaagcgtgc tgaataggat tcttctcagt ttgaaagaca atgaaaaatg gttttgtatg    300

acttgaatag tttgtatagt atataatctt ttctgaacag atgctataga actcttttaa    360

tatgtttaat tcacctatca cactctgtta aaaacacata gaatcatcaa taaaaactca    420

atataacttt ctttgggtct taaagcagga gaatccaaag taaatcctga acaaaaccta    480

aacacagcca tctaactcat taccttaaaa gacattctgt ttattagtct gattaggaat    540

gatggcactg gttgtatttt agccaagaca gtttagcatg gagctattcc ttggtgcagt    600

tcaggatatg aacacaggta cagtcattct ttgaaggtga cactgttctg tatattccct    660

ataggcagct ggagagatct gtgtgacaca agatgctttt gtacgggttc ccatgaatct    720

tctgctcttg tttgtgtgac atggaacaaa taacttcttt gccaccactt tgccttagat    780

aactgtgtgt gtgtgtgcca gtttgaactc tgacaccaca ttttccttct atgcaatcat    840

gcctgtctga taatcttgca ttgctttcct ctgagcttta gtgggtccta gttgcacact    900

ggcctttctg tgctgttttt caatttgcct aataatagca gttaccctga ttgtaattta    960

tgtaacttta aacaggatca cactgtaccc cctgcctgcc ttatttgctt actgagcaca   1020

ggacagaggc aatatacaac tctgggttca cacacaagct gagatgagaa gaggaatgag   1080

ccatatattg gggaaaatca tagtttgtag gtataattat atagtgcttt tctccctcaa   1140

agtatttttc tagccttgaa ttcattttat cttcattatc cctgtgaagt aggtgggaca   1200

agtataaggg gaagaggggt gctgaatttt taggccaaag actgatatta atacaaatca   1260

ctcactaact gtagagcctt gggcattatc agtgaactac tctgagattt actgtcttca   1320

tctgtttaat gagtagaatg tccgtgatgc ctacctcaca gggttgttgt gagggtcaaa   1380

tgagaatgta tgtgaaagat ttgtaaatgg taaagcacta tattcttgtt tgttagtcct   1440

ttttcctttc tttgggtaga cctacagtca gatgttttgt tttatggatc acttattttc   1500

cttactggta gactgtcgtt ttatagacat attcctattt catatattct ctccctgttg   1560

ttagagaacc tatctttgtt tttggtcaaa acacacatag aaaacaaaat gatccaatga   1620

aaactggttt aactagcaaa agccttggca cctgttggag actatgacca agccaataaa   1680

aagggcattt aaatcagccc tgttagtagg aatgtggcta tggctggtgc ctcttctagt   1740

cacaagtttg tttttggagg gggtccagaa gatcattccc ttgcatagat ttctctttta   1800

ccaatttgag tgcctcctac atgggcagca gtggactaag tgctgggtgt gataaagagg   1860

aatgacttaa ttatgagact gtatataatc aaatacagtg tgggttagga cctgtggcag   1920

accattataa taaagcatgg ccccgtgagg gttttgaaag agaga                   1965


<210>  6152
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  6152

Met Leu Val Ala Leu Tyr Glu Glu Pro Glu Lys Pro Asn Ser Ala Leu 
1               5                   10                  15      


Asp Phe Leu Lys His His Leu Gly Ala Ala Thr Pro Glu Asn Pro Glu 
            20                  25                  30          


Ile Glu Leu Leu Arg Leu Glu Leu Ala Glu Met Lys Glu Lys Tyr Glu 
        35                  40                  45              


Ala Ile Val Glu Glu Asn Lys Lys Leu Lys Ala Lys Leu Ala Gln Tyr 
    50                  55                  60                  


Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
65                  70                  


<210>  6153
<211>  1988
<212>  DNA
<213>  Homosapiens

<400>  6153
cactgacccc cggtgtctct tcaggccgcc gactcgaagc gtgagcagtt ccggagtgtt     60

ggtagcctta tatgaagaac cagagaaacc taacagtgct ttggattttt taaagcatca    120

cttaggagct gctactccag aaaatccaga aatagagctg cttcgcctag aactggccga    180

aatgaaagag aagtatgaag ctattgtaga agaaaataaa aaactgaaag caaagcttgc    240

tcagtatgaa ccacctcagg aggagaagcg tgctgaatag gattcttctc agtttgaaag    300

acaatgaaaa atggttttgt atgacttgaa tagtttgtat agtatataat cttttctgaa    360

cagatgctat agaactcttt taatatgttt aattcaccta tcacactctg ttaaaaacac    420

atagaatcat caataaaaac tcaatataac tttctttggg tcttaaagca ggagaatcca    480

aagtaaatcc tgaacaaaac ctaaacacag ccatctaact cattacctta aaagacattc    540

tgtttattag tctgattagg aatgatggca ctggttgtat tttagccaag acagtttagc    600

atggagctat tccttggtgc agttcaggat atgaacacag gtacagtcat tctttgaagg    660

tgacactgtt ctgtatattc cctataggca gctggagaga tctgtgtgac acaagatgct    720

tttgtacggg ttcccatgaa tcttctgctc ttgtttgtgt gacatggaac aaataacttc    780

tttgccacca ctttgcctta gataactgtg tgtgtgtgtg ccagtttgaa ctctgacacc    840

acattttcct tctatgcaat catgcctgtc tgataatctt gcattgcttt cctctgagct    900

ttagtgggtc ctagttgcac actggccttt ctgtgctgtt tttcaatttg cctaataata    960

gcagttaccc tgattgtaat ttatgtaact ttaaacagga tcacactgta ccccctgcct   1020

gccttatttg cttactgagc acaggacaga ggcaatatac aactctgggt tcacacacaa   1080

gctgagatga gaagaggaat gagccatata ttggggaaaa tcatagtttg taggtataat   1140

tatatagtgc ttttctccct caaagtattt ttctagcctt gaattcattt tatcttcatt   1200

atccctgtga agtaggtggg acaagtataa ggggaagagg ggtgctgaat ttttaggcca   1260

aagactgata ttaatacaaa tcactcacta actgtagagc cttgggcatt atcagtgaac   1320

tactctgaga tttactgtct tcatctgttt aatgagtaga atgtccgtga tgcctacctc   1380

acagggttgt tgtgagggtc aaatgagaat gtatgtgaaa gatttgtaaa tggtaaagca   1440

ctatattctt gtttgttagt cctttttcct ttctttgggt agacctacag tcagatgttt   1500

tgttttatgg atcacttatt ttccttactg gtagactgtc gttttataga catattccta   1560

tttcatatat tctctccctg ttgttagaga acctatcttt gtttttggtc aaaacacaca   1620

tagaaaacaa aatgatccaa tgaaaactgg tttaactagc aaaagccttg gcacctgttg   1680

gagactatga ccaagccaat aaaaagggca tttaaatcag ccctgttagt aggaatgtgg   1740

ctatggctgg tgcctcttct agtcacaagt ttgtttttgg agggggtcca gaagatcatt   1800

cccttgcata gatttctctt ttaccaattt gagtgcctcc tacatgggca gcagtggact   1860

aagtgctggg tgtgataaag aggaatgact taattatgag actgtatata atcaaataca   1920

gtgtgggtta ggacctgtgg cagaccatta taataaagca tggccccgtg agggttttga   1980

aagagaga                                                            1988


<210>  6154
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  6154

Met Lys Glu Lys Tyr Glu Ala Ile Val Glu Glu Asn Lys Lys Leu Lys 
1               5                   10                  15      


Ala Lys Leu Ala Gln Tyr Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
            20                  25                  30          


<210>  6155
<211>  2193
<212>  DNA
<213>  Homosapiens

<400>  6155
cggcgtggct gggggcatgc gggcggtagc aagccgctgg tcggctctgg gtgggagtgg     60

ggtcgcgcgc gcaggtttgg gcgggagggc cccgaggtag tgaggcggag gcggggttgc    120

cggactccca gcgccttctt cctgctcggc tcccgggctc tggccactga cccccggtgt    180

ctcttcaggc cgccgactcg aagcgtgagc agttccggag gtacttggag aagtcggggg    240

tgctggacac gctgaccaag gtgttggtag ccttatatga agaaccagag aaacctaaca    300

gtgctttgga ttttttaaag catcacttag gagctgctac tccagaaaat ccagaaatag    360

agctgcttcg cctagaactg gccgaaatga aagagaagta tgaagctatt gtagaagaaa    420

ataaaaaact gaaagcaaag cttgctcagt atgaaccacc tcaggaggag aagcgtgctg    480

aataggattc ttctcagttt gaaagacaat gaaaaatggt tttgtatgac ttgaatagtt    540

tgtatagtat ataatctttt ctgaacagat gctatagaac tcttttaata tgtttaattc    600

acctatcaca ctctgttaaa aacacataga atcatcaata aaaactcaat ataactttct    660

ttgggtctta aagcaggaga atccaaagta aatcctgaac aaaacctaaa cacagccatc    720

taactcatta ccttaaaaga cattctgttt attagtctga ttaggaatga tggcactggt    780

tgtattttag ccaagacagt ttagcatgga gctattcctt ggtgcagttc aggatatgaa    840

cacaggtaca gtcattcttt gaaggtgaca ctgttctgta tattccctat aggcagctgg    900

agagatctgt gtgacacaag atgcttttgt acgggttccc atgaatcttc tgctcttgtt    960

tgtgtgacat ggaacaaata acttctttgc caccactttg ccttagataa ctgtgtgtgt   1020

gtgtgccagt ttgaactctg acaccacatt ttccttctat gcaatcatgc ctgtctgata   1080

atcttgcatt gctttcctct gagctttagt gggtcctagt tgcacactgg cctttctgtg   1140

ctgtttttca atttgcctaa taatagcagt taccctgatt gtaatttatg taactttaaa   1200

caggatcaca ctgtaccccc tgcctgcctt atttgcttac tgagcacagg acagaggcaa   1260

tatacaactc tgggttcaca cacaagctga gatgagaaga ggaatgagcc atatattggg   1320

gaaaatcata gtttgtaggt ataattatat agtgcttttc tccctcaaag tatttttcta   1380

gccttgaatt cattttatct tcattatccc tgtgaagtag gtgggacaag tataagggga   1440

agaggggtgc tgaattttta ggccaaagac tgatattaat acaaatcact cactaactgt   1500

agagccttgg gcattatcag tgaactactc tgagatttac tgtcttcatc tgtttaatga   1560

gtagaatgtc cgtgatgcct acctcacagg gttgttgtga gggtcaaatg agaatgtatg   1620

tgaaagattt gtaaatggta aagcactata ttcttgtttg ttagtccttt ttcctttctt   1680

tgggtagacc tacagtcaga tgttttgttt tatggatcac ttattttcct tactggtaga   1740

ctgtcgtttt atagacatat tcctatttca tatattctct ccctgttgtt agagaaccta   1800

tctttgtttt tggtcaaaac acacatagaa aacaaaatga tccaatgaaa actggtttaa   1860

ctagcaaaag ccttggcacc tgttggagac tatgaccaag ccaataaaaa gggcatttaa   1920

atcagccctg ttagtaggaa tgtggctatg gctggtgcct cttctagtca caagtttgtt   1980

tttggagggg gtccagaaga tcattccctt gcatagattt ctcttttacc aatttgagtg   2040

cctcctacat gggcagcagt ggactaagtg ctgggtgtga taaagaggaa tgacttaatt   2100

atgagactgt atataatcaa atacagtgtg ggttaggacc tgtggcagac cattataata   2160

aagcatggcc ccgtgagggt tttgaaagag aga                                2193


<210>  6156
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  6156

Met Lys Glu Lys Tyr Glu Ala Ile Val Glu Glu Asn Lys Lys Leu Lys 
1               5                   10                  15      


Ala Lys Leu Ala Gln Tyr Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
            20                  25                  30          


<210>  6157
<211>  3478
<212>  DNA
<213>  Homosapiens

<400>  6157
cagttcagaa agggcacagt cagaaccctt cctccttcac aaggagattc tcaatcactt     60

gacattccaa acactgctga ttctttggga gggctgtcct ttgagccagg gttggtcaga    120

acctgtaata atcctgtttg tcctccaaat cacgtagtgt ccctaacgaa caatctcatt    180

ggtaggcggg ttcccacaga tcttcagatc taaacagcgg ttggctttta gacattatat    240

atattatcag agaagtagcc tagtggtcgt ggggcacaga aaaaatagat aggggcagct    300

ctaaagacca gctgttaaga cagacaactg caaactcatt taagcaagag aaaaacagct    360

ctaattcgag attgtgaagc aacacttcta aattcaaaga catagagttg tcaaatcagg    420

attttttttt ttttaaatga tatcctttcg aatgtaactg attttgggaa aatcacatgt    480

tcagaattga ggctaaatgg tttgatcagg ttttctcttt gaagagacca cagccttagg    540

aaatggttct tgatctatac aattccacct tggacactgg gttaattctg tttgcccctg    600

gaacacaatc acgtaagttt ccttctagac tggcatcctg atgtgtcttg agtataatca    660

catgttgcta cctagtaaat aaaatcttaa gaagatccgt ggctttcctt caccagttca    720

tagcatcgtg attcattgcc cggattggac tcgactctac tcactggaca tctaaccact    780

ccacttaatt aacaataccc accctacagg ggtgttgtaa ggattaaaat ttaaaatacc    840

cgtgttttct acagtgcctg gctcaaaagc tactgcaagc tcgttactgc tcatcctcca    900

gaggcccaca tcaagtcagc cacgactcaa ggagactcca aagataaaag ctgaagccaa    960

aatatatgat tctaaacacc ctcctcggct actgcaaagc actgtgagca ctttctcagg   1020

acgagagcca agaagcccag cacctatggg tcaccacagt ttccgaggtc ccagatgaaa   1080

aagatgcgct cgctaccacc gtgcggcggt cctttctctc gcaatagtct caatgctccc   1140

gggccctgcc tccggacgcc aggacagagg taccaaaatc tcacctcctg caaagaaacc   1200

taattgctac gggggccgga agaggaagag gtgcggctcc gacagccaga ggggcgggca   1260

tacgcagcct ccctcggctc agcctgctac tggggatgca gagcgtcctg gtcgccatga   1320

aaacaggcca cacctcggcg atcccggccg gtggtttgca agtgcgcagg cgcgcgcccc   1380

cttccgcgca tgagcagtgc tgctcccaac ccgccagtcg cggtctccgg cgccagctac   1440

gccgctgccg ctgtcactat ggcccattac aaagccgccg actcgaagcg tgagcagttc   1500

cggaggtact tggagaagtc gggggtgctg gacacgctga ccaaggtgtt ggtagcctta   1560

tatgaagaac cagagaaacc taacagtgct ttggattttt taaagcatca cttaggagct   1620

gctactccag aaaatccaga aatagagctg cttcgcctag aactggccga aatgaaagag   1680

aagtatgaag ctattgtaga agaaaataaa aaactgaaag caaagcttgc tcagtatgaa   1740

ccacctcagg aggagaagcg tgctgaatag gattcttctc agtttgaaag acaatgaaaa   1800

atggttttgt atgacttgaa tagtttgtat agtatataat cttttctgaa cagatgctat   1860

agaactcttt taatatgttt aattcaccta tcacactctg ttaaaaacac atagaatcat   1920

caataaaaac tcaatataac tttctttggg tcttaaagca ggagaatcca aagtaaatcc   1980

tgaacaaaac ctaaacacag ccatctaact cattacctta aaagacattc tgtttattag   2040

tctgattagg aatgatggca ctggttgtat tttagccaag acagtttagc atggagctat   2100

tccttggtgc agttcaggat atgaacacag gtacagtcat tctttgaagg tgacactgtt   2160

ctgtatattc cctataggca gctggagaga tctgtgtgac acaagatgct tttgtacggg   2220

ttcccatgaa tcttctgctc ttgtttgtgt gacatggaac aaataacttc tttgccacca   2280

ctttgcctta gataactgtg tgtgtgtgtg ccagtttgaa ctctgacacc acattttcct   2340

tctatgcaat catgcctgtc tgataatctt gcattgcttt cctctgagct ttagtgggtc   2400

ctagttgcac actggccttt ctgtgctgtt tttcaatttg cctaataata gcagttaccc   2460

tgattgtaat ttatgtaact ttaaacagga tcacactgta ccccctgcct gccttatttg   2520

cttactgagc acaggacaga ggcaatatac aactctgggt tcacacacaa gctgagatga   2580

gaagaggaat gagccatata ttggggaaaa tcatagtttg taggtataat tatatagtgc   2640

ttttctccct caaagtattt ttctagcctt gaattcattt tatcttcatt atccctgtga   2700

agtaggtggg acaagtataa ggggaagagg ggtgctgaat ttttaggcca aagactgata   2760

ttaatacaaa tcactcacta actgtagagc cttgggcatt atcagtgaac tactctgaga   2820

tttactgtct tcatctgttt aatgagtaga atgtccgtga tgcctacctc acagggttgt   2880

tgtgagggtc aaatgagaat gtatgtgaaa gatttgtaaa tggtaaagca ctatattctt   2940

gtttgttagt cctttttcct ttctttgggt agacctacag tcagatgttt tgttttatgg   3000

atcacttatt ttccttactg gtagactgtc gttttataga catattccta tttcatatat   3060

tctctccctg ttgttagaga acctatcttt gtttttggtc aaaacacaca tagaaaacaa   3120

aatgatccaa tgaaaactgg tttaactagc aaaagccttg gcacctgttg gagactatga   3180

ccaagccaat aaaaagggca tttaaatcag ccctgttagt aggaatgtgg ctatggctgg   3240

tgcctcttct agtcacaagt ttgtttttgg agggggtcca gaagatcatt cccttgcata   3300

gatttctctt ttaccaattt gagtgcctcc tacatgggca gcagtggact aagtgctggg   3360

tgtgataaag aggaatgact taattatgag actgtatata atcaaataca gtgtgggtta   3420

ggacctgtgg cagaccatta taataaagca tggccccgtg agggttttga aagagaga     3478


<210>  6158
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  6158

Met Ser Ser Ala Ala Pro Asn Pro Pro Val Ala Val Ser Gly Ala Ser 
1               5                   10                  15      


Tyr Ala Ala Ala Ala Val Thr Met Ala His Tyr Lys Ala Ala Asp Ser 
            20                  25                  30          


Lys Arg Glu Gln Phe Arg Arg Tyr Leu Glu Lys Ser Gly Val Leu Asp 
        35                  40                  45              


Thr Leu Thr Lys Val Leu Val Ala Leu Tyr Glu Glu Pro Glu Lys Pro 
    50                  55                  60                  


Asn Ser Ala Leu Asp Phe Leu Lys His His Leu Gly Ala Ala Thr Pro 
65                  70                  75                  80  


Glu Asn Pro Glu Ile Glu Leu Leu Arg Leu Glu Leu Ala Glu Met Lys 
                85                  90                  95      


Glu Lys Tyr Glu Ala Ile Val Glu Glu Asn Lys Lys Leu Lys Ala Lys 
            100                 105                 110         


Leu Ala Gln Tyr Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
        115                 120                 125     


<210>  6159
<211>  3419
<212>  DNA
<213>  Homosapiens

<400>  6159
cagttcagaa agggcacagt cagaaccctt cctccttcac aaggagattc tcaatcactt     60

gacattccaa acactgctga ttctttggga gggctgtcct ttgagccagg gttggtcaga    120

acctgtaata atcctgtttg tcctccaaat cacgtagtgt ccctaacgaa caatctcatt    180

ggtaggcggg ttcccacaga tcttcagatc taaacagcgg ttggctttta gacattatat    240

atattatcag agaagtagcc tagtggtcgt ggggcacaga aaaaatagat aggggcagct    300

ctaaagacca gctgttaaga cagacaactg caaactcatt taagcaagag aaaaacagct    360

ctaattcgag attgtgaagc aacacttcta aattcaaaga catagagttg tcaaatcagg    420

attttttttt ttttaaatga tatcctttcg aatgtaactg attttgggaa aatcacatgt    480

tcagaattga ggctaaatgg tttgatcagg ttttctcttt gaagagacca cagccttagg    540

aaatggttct tgatctatac aattccacct tggacactgg gttaattctg tttgcccctg    600

gaacacaatc acgtaagttt ccttctagac tggcatcctg atgtgtcttg agtataatca    660

catgttgcta cctagtaaat aaaatcttaa gaagatccgt ggctttcctt caccagttca    720

tagcatcgtg attcattgcc cggattggac tcgactctac tcactggaca tctaaccact    780

ccacttaatt aacaataccc accctacagg ggtgttgtaa ggattaaaat ttaaaatacc    840

cgtgttttct acagtgcctg gctcaaaagc tactgcaagc tcgttactgc tcatcctcca    900

gaggcccaca tcaagtcagc cacgactcaa ggagactcca aagataaaag ctgaagccaa    960

aatatatgat tctaaacacc ctcctcggct actgcaaagc actgtgagca ctttctcagg   1020

acgagagcca agaagcccag cacctatggg tcaccacagt ttccgaggtc ccagatgaaa   1080

aagatgcgct cgctaccacc gtgcggcggt cctttctctc gcaatagtct caatgctccc   1140

gggccctgcc tccggacgcc aggacagagg taccaaaatc tcacctcctg caaagaaacc   1200

taattgctac gggggccgga agaggaagag gtgcggctcc gacagccaga ggggcgggca   1260

tacgcagcct ccctcggctc agcctgctac tggggatgca gagcgtcctg gtcgccatga   1320

aaacaggcca cacctcggcg atcccggccg gtggtttgca agtgcgcagg cgcgcgcccc   1380

cttccgcgca tgagcagtgc tgctcccaac ccgccagtcg cggtctccgg cgccagctac   1440

gccgctgccg ctgtcactat ggcccattac aaagccgccg actcgaagcg tgagcagttc   1500

cggaggtact tggagaagtc gggggtgctg gacacgctga ccaaggcatc acttaggagc   1560

tgctactcca gaaaatccag aaatagagct gcttcgccta gaactggccg aaatgaaaga   1620

gaagtatgaa gctattgtag aagaaaataa aaaactgaaa gcaaagcttg ctcagtatga   1680

accacctcag gaggagaagc gtgctgaata ggattcttct cagtttgaaa gacaatgaaa   1740

aatggttttg tatgacttga atagtttgta tagtatataa tcttttctga acagatgcta   1800

tagaactctt ttaatatgtt taattcacct atcacactct gttaaaaaca catagaatca   1860

tcaataaaaa ctcaatataa ctttctttgg gtcttaaagc aggagaatcc aaagtaaatc   1920

ctgaacaaaa cctaaacaca gccatctaac tcattacctt aaaagacatt ctgtttatta   1980

gtctgattag gaatgatggc actggttgta ttttagccaa gacagtttag catggagcta   2040

ttccttggtg cagttcagga tatgaacaca ggtacagtca ttctttgaag gtgacactgt   2100

tctgtatatt ccctataggc agctggagag atctgtgtga cacaagatgc ttttgtacgg   2160

gttcccatga atcttctgct cttgtttgtg tgacatggaa caaataactt ctttgccacc   2220

actttgcctt agataactgt gtgtgtgtgt gccagtttga actctgacac cacattttcc   2280

ttctatgcaa tcatgcctgt ctgataatct tgcattgctt tcctctgagc tttagtgggt   2340

cctagttgca cactggcctt tctgtgctgt ttttcaattt gcctaataat agcagttacc   2400

ctgattgtaa tttatgtaac tttaaacagg atcacactgt accccctgcc tgccttattt   2460

gcttactgag cacaggacag aggcaatata caactctggg ttcacacaca agctgagatg   2520

agaagaggaa tgagccatat attggggaaa atcatagttt gtaggtataa ttatatagtg   2580

cttttctccc tcaaagtatt tttctagcct tgaattcatt ttatcttcat tatccctgtg   2640

aagtaggtgg gacaagtata aggggaagag gggtgctgaa tttttaggcc aaagactgat   2700

attaatacaa atcactcact aactgtagag ccttgggcat tatcagtgaa ctactctgag   2760

atttactgtc ttcatctgtt taatgagtag aatgtccgtg atgcctacct cacagggttg   2820

ttgtgagggt caaatgagaa tgtatgtgaa agatttgtaa atggtaaagc actatattct   2880

tgtttgttag tcctttttcc tttctttggg tagacctaca gtcagatgtt ttgttttatg   2940

gatcacttat tttccttact ggtagactgt cgttttatag acatattcct atttcatata   3000

ttctctccct gttgttagag aacctatctt tgtttttggt caaaacacac atagaaaaca   3060

aaatgatcca atgaaaactg gtttaactag caaaagcctt ggcacctgtt ggagactatg   3120

accaagccaa taaaaagggc atttaaatca gccctgttag taggaatgtg gctatggctg   3180

gtgcctcttc tagtcacaag tttgtttttg gagggggtcc agaagatcat tcccttgcat   3240

agatttctct tttaccaatt tgagtgcctc ctacatgggc agcagtggac taagtgctgg   3300

gtgtgataaa gaggaatgac ttaattatga gactgtatat aatcaaatac agtgtgggtt   3360

aggacctgtg gcagaccatt ataataaagc atggccccgt gagggttttg aaagagaga    3419


<210>  6160
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  6160

Met Ser Ser Ala Ala Pro Asn Pro Pro Val Ala Val Ser Gly Ala Ser 
1               5                   10                  15      


Tyr Ala Ala Ala Ala Val Thr Met Ala His Tyr Lys Ala Ala Asp Ser 
            20                  25                  30          


Lys Arg Glu Gln Phe Arg Arg Tyr Leu Glu Lys Ser Gly Val Leu Asp 
        35                  40                  45              


Thr Leu Thr Lys Ala Ser Leu Arg Ser Cys Tyr Ser Arg Lys Ser Arg 
    50                  55                  60                  


Asn Arg Ala Ala Ser Pro Arg Thr Gly Arg Asn Glu Arg Glu Val 
65                  70                  75                  


<210>  6161
<211>  3931
<212>  DNA
<213>  Homosapiens

<400>  6161
atggtgctgt tttaaaagca aggataagca gaaagggaca tggattttag ttgatggatg     60

actcactcac tacattcaac tgaactgaat ctgctctata ccagcaaagg gacaaattca    120

gaaaataaat tgaagatggc catgctgtaa cttctaaaca tggtttgctt ctcagattta    180

cctaaactaa gaaaggtttg ctttaagaaa tagtgctccc ttcagaatgg aagaatttat    240

ctgcctctta tttgatgtgg atcagagcta agatggctga ctaaataaac atgggggact    300

ggaatctcct tggagatact ctggaggaag ttcacatcca ctccaccatg attggaaaga    360

tctggctcac catcctgttc atatttcgaa tgcttgttct gggtgtagca gctgaagatg    420

tctggaatga tgagcagtct ggcttcatct gcaatacaga acaaccaggc tgcagaaatg    480

tatgctacga ccaggccttt cctatctccc tcattagata ctgggttctg caggtgatat    540

ttgtgtcttc accatccctg gtctacatgg gccatgcatt gtaccgactg agagttcttg    600

aggaagagag gcaaaggatg aaagctcagt taagagtaga actggaggag gtagagtttg    660

aaatgcctag ggatcggagg agattggagc aagagctttg tcagctggag aaaaggaaac    720

taaataaagc tccactcaga ggaaccttgc tttgcactta tgtgatacac attttcactc    780

gctctgtggt tgaagttgga ttcatgattg gacagtacct tttatatgga tttcacttag    840

agccgctatt taagtgccat ggccacccgt gtccaaatat aatcgactgt tttgtctcaa    900

gaccaacaga aaagacaata ttcctattat ttatgcaatc tatagccact atttcacttt    960

tcttaaacat tcttgaaatt ttccacctag gttttaaaaa gattaaaaga gggctttggg   1020

gaaaatacaa gttgaagaag gaacataatg aattccatgc aaacaaggca aaacaaaatg   1080

tagccaaata ccagagcaca tctgcaaatt cactgaagcg actcccttct gcccctgatt   1140

ataatctgtt agtggaaaag caaacacaca ctgcagtgta ccctagttta aattcatctt   1200

ctgtattcca gccaaatcct gacaatcata gtgtaaatga tgagaaatgc attttggatg   1260

aacaggaaac tgtactttct aatgagattt ccacacttag tactagttgt agtcattttc   1320

aacacatcag ttcaaacaat aacaaagaca ctcataaaat atttggaaaa gaacttaatg   1380

gtaaccagtt aatggaaaaa agagaaactg aaggcaaaga cagcaaaagg aactactact   1440

ctagaggtca ccgttctatt ccaggtgttg ctatagatgg agagaacaac atgaggcagt   1500

caccccaaac agttttctcc ttgccagcta actgcgattg gaaaccgcgg tggcttagag   1560

ctacatgggg ttcctctaca gaacatgaaa accgggggtc acctcctaaa gtgcctggct   1620

caaaagctac tgcaagctcg ttactgctca tcctccagag gcccacatca agtcagccac   1680

gactcaagga gactccaaag ataaaagctg aagccaaaat atatgattct aaacaccctc   1740

ctcggctact gcaaagcact gtgagcactt tctcaggacg agagccaaga agcccagcac   1800

ctatgggtca ccacagtttc cgaggtccca gatgaaaaag atgcgctcgc taccaccgtg   1860

cggcggtcct ttctctcgca atagtctcaa tgctcccggg ccctgcctcc ggacgccagg   1920

acagaggccg ccgactcgaa gcgtgagcag ttccggaggt acttggagaa gtcgggggtg   1980

ctggacacgc tgaccaaggt gttggtagcc ttatatgaag aaccagagaa acctaacagt   2040

gctttggatt ttttaaagca tcacttagga gctgctactc cagaaaatcc agaaatagag   2100

ctgcttcgcc tagaactggc cgaaatgaaa gagaagtatg aagctattgt agaagaaaat   2160

aaaaaactga aagcaaagct tgctcagtat gaaccacctc aggaggagaa gcgtgctgaa   2220

taggattctt ctcagtttga aagacaatga aaaatggttt tgtatgactt gaatagtttg   2280

tatagtatat aatcttttct gaacagatgc tatagaactc ttttaatatg tttaattcac   2340

ctatcacact ctgttaaaaa cacatagaat catcaataaa aactcaatat aactttcttt   2400

gggtcttaaa gcaggagaat ccaaagtaaa tcctgaacaa aacctaaaca cagccatcta   2460

actcattacc ttaaaagaca ttctgtttat tagtctgatt aggaatgatg gcactggttg   2520

tattttagcc aagacagttt agcatggagc tattccttgg tgcagttcag gatatgaaca   2580

caggtacagt cattctttga aggtgacact gttctgtata ttccctatag gcagctggag   2640

agatctgtgt gacacaagat gcttttgtac gggttcccat gaatcttctg ctcttgtttg   2700

tgtgacatgg aacaaataac ttctttgcca ccactttgcc ttagataact gtgtgtgtgt   2760

gtgccagttt gaactctgac accacatttt ccttctatgc aatcatgcct gtctgataat   2820

cttgcattgc tttcctctga gctttagtgg gtcctagttg cacactggcc tttctgtgct   2880

gtttttcaat ttgcctaata atagcagtta ccctgattgt aatttatgta actttaaaca   2940

ggatcacact gtaccccctg cctgccttat ttgcttactg agcacaggac agaggcaata   3000

tacaactctg ggttcacaca caagctgaga tgagaagagg aatgagccat atattgggga   3060

aaatcatagt ttgtaggtat aattatatag tgcttttctc cctcaaagta tttttctagc   3120

cttgaattca ttttatcttc attatccctg tgaagtaggt gggacaagta taaggggaag   3180

aggggtgctg aatttttagg ccaaagactg atattaatac aaatcactca ctaactgtag   3240

agccttgggc attatcagtg aactactctg agatttactg tcttcatctg tttaatgagt   3300

agaatgtccg tgatgcctac ctcacagggt tgttgtgagg gtcaaatgag aatgtatgtg   3360

aaagatttgt aaatggtaaa gcactatatt cttgtttgtt agtccttttt cctttctttg   3420

ggtagaccta cagtcagatg ttttgtttta tggatcactt attttcctta ctggtagact   3480

gtcgttttat agacatattc ctatttcata tattctctcc ctgttgttag agaacctatc   3540

tttgtttttg gtcaaaacac acatagaaaa caaaatgatc caatgaaaac tggtttaact   3600

agcaaaagcc ttggcacctg ttggagacta tgaccaagcc aataaaaagg gcatttaaat   3660

cagccctgtt agtaggaatg tggctatggc tggtgcctct tctagtcaca agtttgtttt   3720

tggagggggt ccagaagatc attcccttgc atagatttct cttttaccaa tttgagtgcc   3780

tcctacatgg gcagcagtgg actaagtgct gggtgtgata aagaggaatg acttaattat   3840

gagactgtat ataatcaaat acagtgtggg ttaggacctg tggcagacca ttataataaa   3900

gcatggcccc gtgagggttt tgaaagagag a                                  3931


<210>  6162
<211>  514
<212>  PRT
<213>  Homosapiens

<400>  6162

Met Gly Asp Trp Asn Leu Leu Gly Asp Thr Leu Glu Glu Val His Ile 
1               5                   10                  15      


His Ser Thr Met Ile Gly Lys Ile Trp Leu Thr Ile Leu Phe Ile Phe 
            20                  25                  30          


Arg Met Leu Val Leu Gly Val Ala Ala Glu Asp Val Trp Asn Asp Glu 
        35                  40                  45              


Gln Ser Gly Phe Ile Cys Asn Thr Glu Gln Pro Gly Cys Arg Asn Val 
    50                  55                  60                  


Cys Tyr Asp Gln Ala Phe Pro Ile Ser Leu Ile Arg Tyr Trp Val Leu 
65                  70                  75                  80  


Gln Val Ile Phe Val Ser Ser Pro Ser Leu Val Tyr Met Gly His Ala 
                85                  90                  95      


Leu Tyr Arg Leu Arg Val Leu Glu Glu Glu Arg Gln Arg Met Lys Ala 
            100                 105                 110         


Gln Leu Arg Val Glu Leu Glu Glu Val Glu Phe Glu Met Pro Arg Asp 
        115                 120                 125             


Arg Arg Arg Leu Glu Gln Glu Leu Cys Gln Leu Glu Lys Arg Lys Leu 
    130                 135                 140                 


Asn Lys Ala Pro Leu Arg Gly Thr Leu Leu Cys Thr Tyr Val Ile His 
145                 150                 155                 160 


Ile Phe Thr Arg Ser Val Val Glu Val Gly Phe Met Ile Gly Gln Tyr 
                165                 170                 175     


Leu Leu Tyr Gly Phe His Leu Glu Pro Leu Phe Lys Cys His Gly His 
            180                 185                 190         


Pro Cys Pro Asn Ile Ile Asp Cys Phe Val Ser Arg Pro Thr Glu Lys 
        195                 200                 205             


Thr Ile Phe Leu Leu Phe Met Gln Ser Ile Ala Thr Ile Ser Leu Phe 
    210                 215                 220                 


Leu Asn Ile Leu Glu Ile Phe His Leu Gly Phe Lys Lys Ile Lys Arg 
225                 230                 235                 240 


Gly Leu Trp Gly Lys Tyr Lys Leu Lys Lys Glu His Asn Glu Phe His 
                245                 250                 255     


Ala Asn Lys Ala Lys Gln Asn Val Ala Lys Tyr Gln Ser Thr Ser Ala 
            260                 265                 270         


Asn Ser Leu Lys Arg Leu Pro Ser Ala Pro Asp Tyr Asn Leu Leu Val 
        275                 280                 285             


Glu Lys Gln Thr His Thr Ala Val Tyr Pro Ser Leu Asn Ser Ser Ser 
    290                 295                 300                 


Val Phe Gln Pro Asn Pro Asp Asn His Ser Val Asn Asp Glu Lys Cys 
305                 310                 315                 320 


Ile Leu Asp Glu Gln Glu Thr Val Leu Ser Asn Glu Ile Ser Thr Leu 
                325                 330                 335     


Ser Thr Ser Cys Ser His Phe Gln His Ile Ser Ser Asn Asn Asn Lys 
            340                 345                 350         


Asp Thr His Lys Ile Phe Gly Lys Glu Leu Asn Gly Asn Gln Leu Met 
        355                 360                 365             


Glu Lys Arg Glu Thr Glu Gly Lys Asp Ser Lys Arg Asn Tyr Tyr Ser 
    370                 375                 380                 


Arg Gly His Arg Ser Ile Pro Gly Val Ala Ile Asp Gly Glu Asn Asn 
385                 390                 395                 400 


Met Arg Gln Ser Pro Gln Thr Val Phe Ser Leu Pro Ala Asn Cys Asp 
                405                 410                 415     


Trp Lys Pro Arg Trp Leu Arg Ala Thr Trp Gly Ser Ser Thr Glu His 
            420                 425                 430         


Glu Asn Arg Gly Ser Pro Pro Lys Val Pro Gly Ser Lys Ala Thr Ala 
        435                 440                 445             


Ser Ser Leu Leu Leu Ile Leu Gln Arg Pro Thr Ser Ser Gln Pro Arg 
    450                 455                 460                 


Leu Lys Glu Thr Pro Lys Ile Lys Ala Glu Ala Lys Ile Tyr Asp Ser 
465                 470                 475                 480 


Lys His Pro Pro Arg Leu Leu Gln Ser Thr Val Ser Thr Phe Ser Gly 
                485                 490                 495     


Arg Glu Pro Arg Ser Pro Ala Pro Met Gly His His Ser Phe Arg Gly 
            500                 505                 510         


Pro Arg 
        


<210>  6163
<211>  1434
<212>  DNA
<213>  Homosapiens

<400>  6163
ctatgaagta gctgagtgag cctaatcccc aaatgttggt agccttatat gaagaaccag     60

agaaacctaa cagtgctttg gattttttaa agcatcactt aggagctgct actccagaaa    120

atccagaaat agagctgctt cgcctagaac tggccgaaat gaaagagaag tatgaagcta    180

ttgtagaaga aaataaaaaa ctgaaagcaa agcttgctca gtatgaacca cctcaggagg    240

agaagcgtgc tgaataggat tcttctcagt ttgaaagaca atgaaaaatg gttttgtatg    300

acttgaatag tttgtatagt atataatctt ttctgaacag atgctataga actcttttaa    360

tatgtttaat tcacctatca cactctgtta aaaacacata gaatcatcaa taaaaactca    420

atataacttt ctttgggtct taaagcagga gaatccaaag taaatcctga acaaaaccta    480

aacacagcca tctaactcat taccttaaaa gacattctgt ttattagtct gattaggaat    540

gatggcactg gttgtatttt agccaagaca gtttagcatg gagctattcc ttggtgcagt    600

tcaggatatg aacacaggta cagtcattct ttgaaggtga cactgttctg tatattccct    660

ataggcagct ggagagatct gtgtgacaca agatgctttt gtacgggttc ccatgaatct    720

tctgctcttg tttgtgtgac atggaacaaa taacttcttt gccaccactt tgccttagat    780

aactgtgtgt gtgtgtgcca gtttgaactc tgacaccaca ttttccttct atgcaatcat    840

gcctgtctga taatcttgca ttgctttcct ctgagcttta gtgggtccta gttgcacact    900

ggcctttctg tgctgttttt caatttgcct aataatagca gttaccctga ttgtaattta    960

tgtaacttta aacaggatca cactgtaccc cctgcctgcc ttatttgctt actgagcaca   1020

ggacagaggc aatatacaac tctgggttca cacacaagct gagatgagaa gaggaatgag   1080

ccatatattg gggaaaatca tagtttgtag gtataattat atagtgcttt tctccctcaa   1140

agtatttttc tagccttgaa ttcattttat cttcattatc cctgtgaagt aggtgggaca   1200

agtataaggg gaagaggggt gctgaatttt taggccaaag actgatatta atacaaatca   1260

ctcactaact gtagagcctt gggcattatc agtgaactac tctgagattt actgtcttca   1320

tctgtttaat gagtagaatg tccgtgatgc ctacctcaca gggttgttgt gagggtcaaa   1380

tgagaatgta tgtgaaagat ttgtaaatgg taaagcacta tattcttgtt tgtt         1434


<210>  6164
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  6164

Met Leu Val Ala Leu Tyr Glu Glu Pro Glu Lys Pro Asn Ser Ala Leu 
1               5                   10                  15      


Asp Phe Leu Lys His His Leu Gly Ala Ala Thr Pro Glu Asn Pro Glu 
            20                  25                  30          


Ile Glu Leu Leu Arg Leu Glu Leu Ala Glu Met Lys Glu Lys Tyr Glu 
        35                  40                  45              


Ala Ile Val Glu Glu Asn Lys Lys Leu Lys Ala Lys Leu Ala Gln Tyr 
    50                  55                  60                  


Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
65                  70                  


<210>  6165
<211>  1457
<212>  DNA
<213>  Homosapiens

<400>  6165
cactgacccc cggtgtctct tcaggccgcc gactcgaagc gtgagcagtt ccggagtgtt     60

ggtagcctta tatgaagaac cagagaaacc taacagtgct ttggattttt taaagcatca    120

cttaggagct gctactccag aaaatccaga aatagagctg cttcgcctag aactggccga    180

aatgaaagag aagtatgaag ctattgtaga agaaaataaa aaactgaaag caaagcttgc    240

tcagtatgaa ccacctcagg aggagaagcg tgctgaatag gattcttctc agtttgaaag    300

acaatgaaaa atggttttgt atgacttgaa tagtttgtat agtatataat cttttctgaa    360

cagatgctat agaactcttt taatatgttt aattcaccta tcacactctg ttaaaaacac    420

atagaatcat caataaaaac tcaatataac tttctttggg tcttaaagca ggagaatcca    480

aagtaaatcc tgaacaaaac ctaaacacag ccatctaact cattacctta aaagacattc    540

tgtttattag tctgattagg aatgatggca ctggttgtat tttagccaag acagtttagc    600

atggagctat tccttggtgc agttcaggat atgaacacag gtacagtcat tctttgaagg    660

tgacactgtt ctgtatattc cctataggca gctggagaga tctgtgtgac acaagatgct    720

tttgtacggg ttcccatgaa tcttctgctc ttgtttgtgt gacatggaac aaataacttc    780

tttgccacca ctttgcctta gataactgtg tgtgtgtgtg ccagtttgaa ctctgacacc    840

acattttcct tctatgcaat catgcctgtc tgataatctt gcattgcttt cctctgagct    900

ttagtgggtc ctagttgcac actggccttt ctgtgctgtt tttcaatttg cctaataata    960

gcagttaccc tgattgtaat ttatgtaact ttaaacagga tcacactgta ccccctgcct   1020

gccttatttg cttactgagc acaggacaga ggcaatatac aactctgggt tcacacacaa   1080

gctgagatga gaagaggaat gagccatata ttggggaaaa tcatagtttg taggtataat   1140

tatatagtgc ttttctccct caaagtattt ttctagcctt gaattcattt tatcttcatt   1200

atccctgtga agtaggtggg acaagtataa ggggaagagg ggtgctgaat ttttaggcca   1260

aagactgata ttaatacaaa tcactcacta actgtagagc cttgggcatt atcagtgaac   1320

tactctgaga tttactgtct tcatctgttt aatgagtaga atgtccgtga tgcctacctc   1380

acagggttgt tgtgagggtc aaatgagaat gtatgtgaaa gatttgtaaa tggtaaagca   1440

ctatattctt gtttgtt                                                  1457


<210>  6166
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  6166

Met Lys Glu Lys Tyr Glu Ala Ile Val Glu Glu Asn Lys Lys Leu Lys 
1               5                   10                  15      


Ala Lys Leu Ala Gln Tyr Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
            20                  25                  30          


<210>  6167
<211>  1662
<212>  DNA
<213>  Homosapiens

<400>  6167
cggcgtggct gggggcatgc gggcggtagc aagccgctgg tcggctctgg gtgggagtgg     60

ggtcgcgcgc gcaggtttgg gcgggagggc cccgaggtag tgaggcggag gcggggttgc    120

cggactccca gcgccttctt cctgctcggc tcccgggctc tggccactga cccccggtgt    180

ctcttcaggc cgccgactcg aagcgtgagc agttccggag gtacttggag aagtcggggg    240

tgctggacac gctgaccaag gtgttggtag ccttatatga agaaccagag aaacctaaca    300

gtgctttgga ttttttaaag catcacttag gagctgctac tccagaaaat ccagaaatag    360

agctgcttcg cctagaactg gccgaaatga aagagaagta tgaagctatt gtagaagaaa    420

ataaaaaact gaaagcaaag cttgctcagt atgaaccacc tcaggaggag aagcgtgctg    480

aataggattc ttctcagttt gaaagacaat gaaaaatggt tttgtatgac ttgaatagtt    540

tgtatagtat ataatctttt ctgaacagat gctatagaac tcttttaata tgtttaattc    600

acctatcaca ctctgttaaa aacacataga atcatcaata aaaactcaat ataactttct    660

ttgggtctta aagcaggaga atccaaagta aatcctgaac aaaacctaaa cacagccatc    720

taactcatta ccttaaaaga cattctgttt attagtctga ttaggaatga tggcactggt    780

tgtattttag ccaagacagt ttagcatgga gctattcctt ggtgcagttc aggatatgaa    840

cacaggtaca gtcattcttt gaaggtgaca ctgttctgta tattccctat aggcagctgg    900

agagatctgt gtgacacaag atgcttttgt acgggttccc atgaatcttc tgctcttgtt    960

tgtgtgacat ggaacaaata acttctttgc caccactttg ccttagataa ctgtgtgtgt   1020

gtgtgccagt ttgaactctg acaccacatt ttccttctat gcaatcatgc ctgtctgata   1080

atcttgcatt gctttcctct gagctttagt gggtcctagt tgcacactgg cctttctgtg   1140

ctgtttttca atttgcctaa taatagcagt taccctgatt gtaatttatg taactttaaa   1200

caggatcaca ctgtaccccc tgcctgcctt atttgcttac tgagcacagg acagaggcaa   1260

tatacaactc tgggttcaca cacaagctga gatgagaaga ggaatgagcc atatattggg   1320

gaaaatcata gtttgtaggt ataattatat agtgcttttc tccctcaaag tatttttcta   1380

gccttgaatt cattttatct tcattatccc tgtgaagtag gtgggacaag tataagggga   1440

agaggggtgc tgaattttta ggccaaagac tgatattaat acaaatcact cactaactgt   1500

agagccttgg gcattatcag tgaactactc tgagatttac tgtcttcatc tgtttaatga   1560

gtagaatgtc cgtgatgcct acctcacagg gttgttgtga gggtcaaatg agaatgtatg   1620

tgaaagattt gtaaatggta aagcactata ttcttgtttg tt                      1662


<210>  6168
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  6168

Met Lys Glu Lys Tyr Glu Ala Ile Val Glu Glu Asn Lys Lys Leu Lys 
1               5                   10                  15      


Ala Lys Leu Ala Gln Tyr Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
            20                  25                  30          


<210>  6169
<211>  2947
<212>  DNA
<213>  Homosapiens

<400>  6169
cagttcagaa agggcacagt cagaaccctt cctccttcac aaggagattc tcaatcactt     60

gacattccaa acactgctga ttctttggga gggctgtcct ttgagccagg gttggtcaga    120

acctgtaata atcctgtttg tcctccaaat cacgtagtgt ccctaacgaa caatctcatt    180

ggtaggcggg ttcccacaga tcttcagatc taaacagcgg ttggctttta gacattatat    240

atattatcag agaagtagcc tagtggtcgt ggggcacaga aaaaatagat aggggcagct    300

ctaaagacca gctgttaaga cagacaactg caaactcatt taagcaagag aaaaacagct    360

ctaattcgag attgtgaagc aacacttcta aattcaaaga catagagttg tcaaatcagg    420

attttttttt ttttaaatga tatcctttcg aatgtaactg attttgggaa aatcacatgt    480

tcagaattga ggctaaatgg tttgatcagg ttttctcttt gaagagacca cagccttagg    540

aaatggttct tgatctatac aattccacct tggacactgg gttaattctg tttgcccctg    600

gaacacaatc acgtaagttt ccttctagac tggcatcctg atgtgtcttg agtataatca    660

catgttgcta cctagtaaat aaaatcttaa gaagatccgt ggctttcctt caccagttca    720

tagcatcgtg attcattgcc cggattggac tcgactctac tcactggaca tctaaccact    780

ccacttaatt aacaataccc accctacagg ggtgttgtaa ggattaaaat ttaaaatacc    840

cgtgttttct acagtgcctg gctcaaaagc tactgcaagc tcgttactgc tcatcctcca    900

gaggcccaca tcaagtcagc cacgactcaa ggagactcca aagataaaag ctgaagccaa    960

aatatatgat tctaaacacc ctcctcggct actgcaaagc actgtgagca ctttctcagg   1020

acgagagcca agaagcccag cacctatggg tcaccacagt ttccgaggtc ccagatgaaa   1080

aagatgcgct cgctaccacc gtgcggcggt cctttctctc gcaatagtct caatgctccc   1140

gggccctgcc tccggacgcc aggacagagg taccaaaatc tcacctcctg caaagaaacc   1200

taattgctac gggggccgga agaggaagag gtgcggctcc gacagccaga ggggcgggca   1260

tacgcagcct ccctcggctc agcctgctac tggggatgca gagcgtcctg gtcgccatga   1320

aaacaggcca cacctcggcg atcccggccg gtggtttgca agtgcgcagg cgcgcgcccc   1380

cttccgcgca tgagcagtgc tgctcccaac ccgccagtcg cggtctccgg cgccagctac   1440

gccgctgccg ctgtcactat ggcccattac aaagccgccg actcgaagcg tgagcagttc   1500

cggaggtact tggagaagtc gggggtgctg gacacgctga ccaaggtgtt ggtagcctta   1560

tatgaagaac cagagaaacc taacagtgct ttggattttt taaagcatca cttaggagct   1620

gctactccag aaaatccaga aatagagctg cttcgcctag aactggccga aatgaaagag   1680

aagtatgaag ctattgtaga agaaaataaa aaactgaaag caaagcttgc tcagtatgaa   1740

ccacctcagg aggagaagcg tgctgaatag gattcttctc agtttgaaag acaatgaaaa   1800

atggttttgt atgacttgaa tagtttgtat agtatataat cttttctgaa cagatgctat   1860

agaactcttt taatatgttt aattcaccta tcacactctg ttaaaaacac atagaatcat   1920

caataaaaac tcaatataac tttctttggg tcttaaagca ggagaatcca aagtaaatcc   1980

tgaacaaaac ctaaacacag ccatctaact cattacctta aaagacattc tgtttattag   2040

tctgattagg aatgatggca ctggttgtat tttagccaag acagtttagc atggagctat   2100

tccttggtgc agttcaggat atgaacacag gtacagtcat tctttgaagg tgacactgtt   2160

ctgtatattc cctataggca gctggagaga tctgtgtgac acaagatgct tttgtacggg   2220

ttcccatgaa tcttctgctc ttgtttgtgt gacatggaac aaataacttc tttgccacca   2280

ctttgcctta gataactgtg tgtgtgtgtg ccagtttgaa ctctgacacc acattttcct   2340

tctatgcaat catgcctgtc tgataatctt gcattgcttt cctctgagct ttagtgggtc   2400

ctagttgcac actggccttt ctgtgctgtt tttcaatttg cctaataata gcagttaccc   2460

tgattgtaat ttatgtaact ttaaacagga tcacactgta ccccctgcct gccttatttg   2520

cttactgagc acaggacaga ggcaatatac aactctgggt tcacacacaa gctgagatga   2580

gaagaggaat gagccatata ttggggaaaa tcatagtttg taggtataat tatatagtgc   2640

ttttctccct caaagtattt ttctagcctt gaattcattt tatcttcatt atccctgtga   2700

agtaggtggg acaagtataa ggggaagagg ggtgctgaat ttttaggcca aagactgata   2760

ttaatacaaa tcactcacta actgtagagc cttgggcatt atcagtgaac tactctgaga   2820

tttactgtct tcatctgttt aatgagtaga atgtccgtga tgcctacctc acagggttgt   2880

tgtgagggtc aaatgagaat gtatgtgaaa gatttgtaaa tggtaaagca ctatattctt   2940

gtttgtt                                                             2947


<210>  6170
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  6170

Met Ser Ser Ala Ala Pro Asn Pro Pro Val Ala Val Ser Gly Ala Ser 
1               5                   10                  15      


Tyr Ala Ala Ala Ala Val Thr Met Ala His Tyr Lys Ala Ala Asp Ser 
            20                  25                  30          


Lys Arg Glu Gln Phe Arg Arg Tyr Leu Glu Lys Ser Gly Val Leu Asp 
        35                  40                  45              


Thr Leu Thr Lys Val Leu Val Ala Leu Tyr Glu Glu Pro Glu Lys Pro 
    50                  55                  60                  


Asn Ser Ala Leu Asp Phe Leu Lys His His Leu Gly Ala Ala Thr Pro 
65                  70                  75                  80  


Glu Asn Pro Glu Ile Glu Leu Leu Arg Leu Glu Leu Ala Glu Met Lys 
                85                  90                  95      


Glu Lys Tyr Glu Ala Ile Val Glu Glu Asn Lys Lys Leu Lys Ala Lys 
            100                 105                 110         


Leu Ala Gln Tyr Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
        115                 120                 125     


<210>  6171
<211>  2888
<212>  DNA
<213>  Homosapiens

<400>  6171
cagttcagaa agggcacagt cagaaccctt cctccttcac aaggagattc tcaatcactt     60

gacattccaa acactgctga ttctttggga gggctgtcct ttgagccagg gttggtcaga    120

acctgtaata atcctgtttg tcctccaaat cacgtagtgt ccctaacgaa caatctcatt    180

ggtaggcggg ttcccacaga tcttcagatc taaacagcgg ttggctttta gacattatat    240

atattatcag agaagtagcc tagtggtcgt ggggcacaga aaaaatagat aggggcagct    300

ctaaagacca gctgttaaga cagacaactg caaactcatt taagcaagag aaaaacagct    360

ctaattcgag attgtgaagc aacacttcta aattcaaaga catagagttg tcaaatcagg    420

attttttttt ttttaaatga tatcctttcg aatgtaactg attttgggaa aatcacatgt    480

tcagaattga ggctaaatgg tttgatcagg ttttctcttt gaagagacca cagccttagg    540

aaatggttct tgatctatac aattccacct tggacactgg gttaattctg tttgcccctg    600

gaacacaatc acgtaagttt ccttctagac tggcatcctg atgtgtcttg agtataatca    660

catgttgcta cctagtaaat aaaatcttaa gaagatccgt ggctttcctt caccagttca    720

tagcatcgtg attcattgcc cggattggac tcgactctac tcactggaca tctaaccact    780

ccacttaatt aacaataccc accctacagg ggtgttgtaa ggattaaaat ttaaaatacc    840

cgtgttttct acagtgcctg gctcaaaagc tactgcaagc tcgttactgc tcatcctcca    900

gaggcccaca tcaagtcagc cacgactcaa ggagactcca aagataaaag ctgaagccaa    960

aatatatgat tctaaacacc ctcctcggct actgcaaagc actgtgagca ctttctcagg   1020

acgagagcca agaagcccag cacctatggg tcaccacagt ttccgaggtc ccagatgaaa   1080

aagatgcgct cgctaccacc gtgcggcggt cctttctctc gcaatagtct caatgctccc   1140

gggccctgcc tccggacgcc aggacagagg taccaaaatc tcacctcctg caaagaaacc   1200

taattgctac gggggccgga agaggaagag gtgcggctcc gacagccaga ggggcgggca   1260

tacgcagcct ccctcggctc agcctgctac tggggatgca gagcgtcctg gtcgccatga   1320

aaacaggcca cacctcggcg atcccggccg gtggtttgca agtgcgcagg cgcgcgcccc   1380

cttccgcgca tgagcagtgc tgctcccaac ccgccagtcg cggtctccgg cgccagctac   1440

gccgctgccg ctgtcactat ggcccattac aaagccgccg actcgaagcg tgagcagttc   1500

cggaggtact tggagaagtc gggggtgctg gacacgctga ccaaggcatc acttaggagc   1560

tgctactcca gaaaatccag aaatagagct gcttcgccta gaactggccg aaatgaaaga   1620

gaagtatgaa gctattgtag aagaaaataa aaaactgaaa gcaaagcttg ctcagtatga   1680

accacctcag gaggagaagc gtgctgaata ggattcttct cagtttgaaa gacaatgaaa   1740

aatggttttg tatgacttga atagtttgta tagtatataa tcttttctga acagatgcta   1800

tagaactctt ttaatatgtt taattcacct atcacactct gttaaaaaca catagaatca   1860

tcaataaaaa ctcaatataa ctttctttgg gtcttaaagc aggagaatcc aaagtaaatc   1920

ctgaacaaaa cctaaacaca gccatctaac tcattacctt aaaagacatt ctgtttatta   1980

gtctgattag gaatgatggc actggttgta ttttagccaa gacagtttag catggagcta   2040

ttccttggtg cagttcagga tatgaacaca ggtacagtca ttctttgaag gtgacactgt   2100

tctgtatatt ccctataggc agctggagag atctgtgtga cacaagatgc ttttgtacgg   2160

gttcccatga atcttctgct cttgtttgtg tgacatggaa caaataactt ctttgccacc   2220

actttgcctt agataactgt gtgtgtgtgt gccagtttga actctgacac cacattttcc   2280

ttctatgcaa tcatgcctgt ctgataatct tgcattgctt tcctctgagc tttagtgggt   2340

cctagttgca cactggcctt tctgtgctgt ttttcaattt gcctaataat agcagttacc   2400

ctgattgtaa tttatgtaac tttaaacagg atcacactgt accccctgcc tgccttattt   2460

gcttactgag cacaggacag aggcaatata caactctggg ttcacacaca agctgagatg   2520

agaagaggaa tgagccatat attggggaaa atcatagttt gtaggtataa ttatatagtg   2580

cttttctccc tcaaagtatt tttctagcct tgaattcatt ttatcttcat tatccctgtg   2640

aagtaggtgg gacaagtata aggggaagag gggtgctgaa tttttaggcc aaagactgat   2700

attaatacaa atcactcact aactgtagag ccttgggcat tatcagtgaa ctactctgag   2760

atttactgtc ttcatctgtt taatgagtag aatgtccgtg atgcctacct cacagggttg   2820

ttgtgagggt caaatgagaa tgtatgtgaa agatttgtaa atggtaaagc actatattct   2880

tgtttgtt                                                            2888


<210>  6172
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  6172

Met Ser Ser Ala Ala Pro Asn Pro Pro Val Ala Val Ser Gly Ala Ser 
1               5                   10                  15      


Tyr Ala Ala Ala Ala Val Thr Met Ala His Tyr Lys Ala Ala Asp Ser 
            20                  25                  30          


Lys Arg Glu Gln Phe Arg Arg Tyr Leu Glu Lys Ser Gly Val Leu Asp 
        35                  40                  45              


Thr Leu Thr Lys Ala Ser Leu Arg Ser Cys Tyr Ser Arg Lys Ser Arg 
    50                  55                  60                  


Asn Arg Ala Ala Ser Pro Arg Thr Gly Arg Asn Glu Arg Glu Val 
65                  70                  75                  


<210>  6173
<211>  3400
<212>  DNA
<213>  Homosapiens

<400>  6173
atggtgctgt tttaaaagca aggataagca gaaagggaca tggattttag ttgatggatg     60

actcactcac tacattcaac tgaactgaat ctgctctata ccagcaaagg gacaaattca    120

gaaaataaat tgaagatggc catgctgtaa cttctaaaca tggtttgctt ctcagattta    180

cctaaactaa gaaaggtttg ctttaagaaa tagtgctccc ttcagaatgg aagaatttat    240

ctgcctctta tttgatgtgg atcagagcta agatggctga ctaaataaac atgggggact    300

ggaatctcct tggagatact ctggaggaag ttcacatcca ctccaccatg attggaaaga    360

tctggctcac catcctgttc atatttcgaa tgcttgttct gggtgtagca gctgaagatg    420

tctggaatga tgagcagtct ggcttcatct gcaatacaga acaaccaggc tgcagaaatg    480

tatgctacga ccaggccttt cctatctccc tcattagata ctgggttctg caggtgatat    540

ttgtgtcttc accatccctg gtctacatgg gccatgcatt gtaccgactg agagttcttg    600

aggaagagag gcaaaggatg aaagctcagt taagagtaga actggaggag gtagagtttg    660

aaatgcctag ggatcggagg agattggagc aagagctttg tcagctggag aaaaggaaac    720

taaataaagc tccactcaga ggaaccttgc tttgcactta tgtgatacac attttcactc    780

gctctgtggt tgaagttgga ttcatgattg gacagtacct tttatatgga tttcacttag    840

agccgctatt taagtgccat ggccacccgt gtccaaatat aatcgactgt tttgtctcaa    900

gaccaacaga aaagacaata ttcctattat ttatgcaatc tatagccact atttcacttt    960

tcttaaacat tcttgaaatt ttccacctag gttttaaaaa gattaaaaga gggctttggg   1020

gaaaatacaa gttgaagaag gaacataatg aattccatgc aaacaaggca aaacaaaatg   1080

tagccaaata ccagagcaca tctgcaaatt cactgaagcg actcccttct gcccctgatt   1140

ataatctgtt agtggaaaag caaacacaca ctgcagtgta ccctagttta aattcatctt   1200

ctgtattcca gccaaatcct gacaatcata gtgtaaatga tgagaaatgc attttggatg   1260

aacaggaaac tgtactttct aatgagattt ccacacttag tactagttgt agtcattttc   1320

aacacatcag ttcaaacaat aacaaagaca ctcataaaat atttggaaaa gaacttaatg   1380

gtaaccagtt aatggaaaaa agagaaactg aaggcaaaga cagcaaaagg aactactact   1440

ctagaggtca ccgttctatt ccaggtgttg ctatagatgg agagaacaac atgaggcagt   1500

caccccaaac agttttctcc ttgccagcta actgcgattg gaaaccgcgg tggcttagag   1560

ctacatgggg ttcctctaca gaacatgaaa accgggggtc acctcctaaa gtgcctggct   1620

caaaagctac tgcaagctcg ttactgctca tcctccagag gcccacatca agtcagccac   1680

gactcaagga gactccaaag ataaaagctg aagccaaaat atatgattct aaacaccctc   1740

ctcggctact gcaaagcact gtgagcactt tctcaggacg agagccaaga agcccagcac   1800

ctatgggtca ccacagtttc cgaggtccca gatgaaaaag atgcgctcgc taccaccgtg   1860

cggcggtcct ttctctcgca atagtctcaa tgctcccggg ccctgcctcc ggacgccagg   1920

acagaggccg ccgactcgaa gcgtgagcag ttccggaggt acttggagaa gtcgggggtg   1980

ctggacacgc tgaccaaggt gttggtagcc ttatatgaag aaccagagaa acctaacagt   2040

gctttggatt ttttaaagca tcacttagga gctgctactc cagaaaatcc agaaatagag   2100

ctgcttcgcc tagaactggc cgaaatgaaa gagaagtatg aagctattgt agaagaaaat   2160

aaaaaactga aagcaaagct tgctcagtat gaaccacctc aggaggagaa gcgtgctgaa   2220

taggattctt ctcagtttga aagacaatga aaaatggttt tgtatgactt gaatagtttg   2280

tatagtatat aatcttttct gaacagatgc tatagaactc ttttaatatg tttaattcac   2340

ctatcacact ctgttaaaaa cacatagaat catcaataaa aactcaatat aactttcttt   2400

gggtcttaaa gcaggagaat ccaaagtaaa tcctgaacaa aacctaaaca cagccatcta   2460

actcattacc ttaaaagaca ttctgtttat tagtctgatt aggaatgatg gcactggttg   2520

tattttagcc aagacagttt agcatggagc tattccttgg tgcagttcag gatatgaaca   2580

caggtacagt cattctttga aggtgacact gttctgtata ttccctatag gcagctggag   2640

agatctgtgt gacacaagat gcttttgtac gggttcccat gaatcttctg ctcttgtttg   2700

tgtgacatgg aacaaataac ttctttgcca ccactttgcc ttagataact gtgtgtgtgt   2760

gtgccagttt gaactctgac accacatttt ccttctatgc aatcatgcct gtctgataat   2820

cttgcattgc tttcctctga gctttagtgg gtcctagttg cacactggcc tttctgtgct   2880

gtttttcaat ttgcctaata atagcagtta ccctgattgt aatttatgta actttaaaca   2940

ggatcacact gtaccccctg cctgccttat ttgcttactg agcacaggac agaggcaata   3000

tacaactctg ggttcacaca caagctgaga tgagaagagg aatgagccat atattgggga   3060

aaatcatagt ttgtaggtat aattatatag tgcttttctc cctcaaagta tttttctagc   3120

cttgaattca ttttatcttc attatccctg tgaagtaggt gggacaagta taaggggaag   3180

aggggtgctg aatttttagg ccaaagactg atattaatac aaatcactca ctaactgtag   3240

agccttgggc attatcagtg aactactctg agatttactg tcttcatctg tttaatgagt   3300

agaatgtccg tgatgcctac ctcacagggt tgttgtgagg gtcaaatgag aatgtatgtg   3360

aaagatttgt aaatggtaaa gcactatatt cttgtttgtt                         3400


<210>  6174
<211>  514
<212>  PRT
<213>  Homosapiens

<400>  6174

Met Gly Asp Trp Asn Leu Leu Gly Asp Thr Leu Glu Glu Val His Ile 
1               5                   10                  15      


His Ser Thr Met Ile Gly Lys Ile Trp Leu Thr Ile Leu Phe Ile Phe 
            20                  25                  30          


Arg Met Leu Val Leu Gly Val Ala Ala Glu Asp Val Trp Asn Asp Glu 
        35                  40                  45              


Gln Ser Gly Phe Ile Cys Asn Thr Glu Gln Pro Gly Cys Arg Asn Val 
    50                  55                  60                  


Cys Tyr Asp Gln Ala Phe Pro Ile Ser Leu Ile Arg Tyr Trp Val Leu 
65                  70                  75                  80  


Gln Val Ile Phe Val Ser Ser Pro Ser Leu Val Tyr Met Gly His Ala 
                85                  90                  95      


Leu Tyr Arg Leu Arg Val Leu Glu Glu Glu Arg Gln Arg Met Lys Ala 
            100                 105                 110         


Gln Leu Arg Val Glu Leu Glu Glu Val Glu Phe Glu Met Pro Arg Asp 
        115                 120                 125             


Arg Arg Arg Leu Glu Gln Glu Leu Cys Gln Leu Glu Lys Arg Lys Leu 
    130                 135                 140                 


Asn Lys Ala Pro Leu Arg Gly Thr Leu Leu Cys Thr Tyr Val Ile His 
145                 150                 155                 160 


Ile Phe Thr Arg Ser Val Val Glu Val Gly Phe Met Ile Gly Gln Tyr 
                165                 170                 175     


Leu Leu Tyr Gly Phe His Leu Glu Pro Leu Phe Lys Cys His Gly His 
            180                 185                 190         


Pro Cys Pro Asn Ile Ile Asp Cys Phe Val Ser Arg Pro Thr Glu Lys 
        195                 200                 205             


Thr Ile Phe Leu Leu Phe Met Gln Ser Ile Ala Thr Ile Ser Leu Phe 
    210                 215                 220                 


Leu Asn Ile Leu Glu Ile Phe His Leu Gly Phe Lys Lys Ile Lys Arg 
225                 230                 235                 240 


Gly Leu Trp Gly Lys Tyr Lys Leu Lys Lys Glu His Asn Glu Phe His 
                245                 250                 255     


Ala Asn Lys Ala Lys Gln Asn Val Ala Lys Tyr Gln Ser Thr Ser Ala 
            260                 265                 270         


Asn Ser Leu Lys Arg Leu Pro Ser Ala Pro Asp Tyr Asn Leu Leu Val 
        275                 280                 285             


Glu Lys Gln Thr His Thr Ala Val Tyr Pro Ser Leu Asn Ser Ser Ser 
    290                 295                 300                 


Val Phe Gln Pro Asn Pro Asp Asn His Ser Val Asn Asp Glu Lys Cys 
305                 310                 315                 320 


Ile Leu Asp Glu Gln Glu Thr Val Leu Ser Asn Glu Ile Ser Thr Leu 
                325                 330                 335     


Ser Thr Ser Cys Ser His Phe Gln His Ile Ser Ser Asn Asn Asn Lys 
            340                 345                 350         


Asp Thr His Lys Ile Phe Gly Lys Glu Leu Asn Gly Asn Gln Leu Met 
        355                 360                 365             


Glu Lys Arg Glu Thr Glu Gly Lys Asp Ser Lys Arg Asn Tyr Tyr Ser 
    370                 375                 380                 


Arg Gly His Arg Ser Ile Pro Gly Val Ala Ile Asp Gly Glu Asn Asn 
385                 390                 395                 400 


Met Arg Gln Ser Pro Gln Thr Val Phe Ser Leu Pro Ala Asn Cys Asp 
                405                 410                 415     


Trp Lys Pro Arg Trp Leu Arg Ala Thr Trp Gly Ser Ser Thr Glu His 
            420                 425                 430         


Glu Asn Arg Gly Ser Pro Pro Lys Val Pro Gly Ser Lys Ala Thr Ala 
        435                 440                 445             


Ser Ser Leu Leu Leu Ile Leu Gln Arg Pro Thr Ser Ser Gln Pro Arg 
    450                 455                 460                 


Leu Lys Glu Thr Pro Lys Ile Lys Ala Glu Ala Lys Ile Tyr Asp Ser 
465                 470                 475                 480 


Lys His Pro Pro Arg Leu Leu Gln Ser Thr Val Ser Thr Phe Ser Gly 
                485                 490                 495     


Arg Glu Pro Arg Ser Pro Ala Pro Met Gly His His Ser Phe Arg Gly 
            500                 505                 510         


Pro Arg 
        


<210>  6175
<211>  1944
<212>  DNA
<213>  Homosapiens

<400>  6175
cagttcagaa agggcacagt cagaaccctt cctccttcac aaggagattc tcaatcactt     60

gacattccaa acactgctga ttctttggga gggctgtcct ttgagccagg gttggtcaga    120

acctgtaata atcctgtttg tcctccaaat cacgtagtgt ccctaacgaa caatctcatt    180

ggtaggcggg ttcccacaga tcttcagatc taaacagcgg ttggctttta gacattatat    240

atattatcag agaagtagcc tagtggtcgt ggggcacaga aaaaatagat aggggcagct    300

ctaaagacca gctgttaaga cagacaactg caaactcatt taagcaagag aaaaacagct    360

ctaattcgag attgtgaagc aacacttcta aattcaaaga catagagttg tcaaatcagg    420

attttttttt ttttaaatga tatcctttcg aatgtaactg attttgggaa aatcacatgt    480

tcagaattga ggctaaatgg tttgatcagg ttttctcttt gaagagacca cagccttagg    540

aaatggttct tgatctatac aattccacct tggacactgg gttaattctg tttgcccctg    600

gaacacaatc acgtaagttt ccttctagac tggcatcctg atgtgtcttg agtataatca    660

catgttgcta cctagtaaat aaaatcttaa gaagatccgt ggctttcctt caccagttca    720

tagcatcgtg attcattgcc cggattggac tcgactctac tcactggaca tctaaccact    780

ccacttaatt aacaataccc accctacagg ggtgttgtaa ggattaaaat ttaaaatacc    840

cgtgttttct acagtgcctg gctcaaaagc tactgcaagc tcgttactgc tcatcctcca    900

gaggcccaca tcaagtcagc cacgactcaa ggagactcca aagataaaag ctgaagccaa    960

aatatatgat tctaaacacc ctcctcggct actgcaaagc actgtgagca ctttctcagg   1020

acgagagcca agaagcccag cacctatggg tcaccacagt ttccgaggtc ccagatgaaa   1080

aagatgcgct cgctaccacc gtgcggcggt cctttctctc gcaatagtct caatgctccc   1140

gggccctgcc tccggacgcc aggacagagg taccaaaatc tcacctcctg caaagaaacc   1200

taattgctac gggggccgga agaggaagag gtgcggctcc gacagccaga ggggcgggca   1260

tacgcagcct ccctcggctc agcctgctac tggggatgca gagcgtcctg gtcgccatga   1320

aaacaggcca cacctcggcg atcccggccg gtggtttgca agtgcgcagg cgcgcgcccc   1380

cttccgcgca tgagcagtgc tgctcccaac ccgccagtcg cggtctccgg cgccagctac   1440

gccgctgccg ctgtcactat ggcccattac aaagccgccg actcgaagcg tgagcagttc   1500

cggaggtact tggagaagtc gggggtgctg gacacgctga ccaaggtgtt ggtagcctta   1560

tatgaagaac cagagaaacc taacagtgct ttggattttt taaagcatca cttaggagct   1620

gctactccag aaaatccaga aatagagctg cttcgcctag aactggccga aatgaaagag   1680

aagtatgaag ctattgtaga agaaaataaa aaactgaaag caaagcttgc tcagtatgaa   1740

ccacctcagg aggagaagcg tgctgaatag gattcttctc agtttgaaag acaatgaaaa   1800

atggttttgt atgacttgaa tagtttgtat agtatataat cttttctgaa cagatgctat   1860

agaactcttt taatatgttt aattcaccta tcacactctg ttaaaaacac atagaatcat   1920

caataaaaac tcaatataac tttc                                          1944


<210>  6176
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  6176

Met Ser Ser Ala Ala Pro Asn Pro Pro Val Ala Val Ser Gly Ala Ser 
1               5                   10                  15      


Tyr Ala Ala Ala Ala Val Thr Met Ala His Tyr Lys Ala Ala Asp Ser 
            20                  25                  30          


Lys Arg Glu Gln Phe Arg Arg Tyr Leu Glu Lys Ser Gly Val Leu Asp 
        35                  40                  45              


Thr Leu Thr Lys Val Leu Val Ala Leu Tyr Glu Glu Pro Glu Lys Pro 
    50                  55                  60                  


Asn Ser Ala Leu Asp Phe Leu Lys His His Leu Gly Ala Ala Thr Pro 
65                  70                  75                  80  


Glu Asn Pro Glu Ile Glu Leu Leu Arg Leu Glu Leu Ala Glu Met Lys 
                85                  90                  95      


Glu Lys Tyr Glu Ala Ile Val Glu Glu Asn Lys Lys Leu Lys Ala Lys 
            100                 105                 110         


Leu Ala Gln Tyr Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
        115                 120                 125     


<210>  6177
<211>  1885
<212>  DNA
<213>  Homosapiens

<400>  6177
cagttcagaa agggcacagt cagaaccctt cctccttcac aaggagattc tcaatcactt     60

gacattccaa acactgctga ttctttggga gggctgtcct ttgagccagg gttggtcaga    120

acctgtaata atcctgtttg tcctccaaat cacgtagtgt ccctaacgaa caatctcatt    180

ggtaggcggg ttcccacaga tcttcagatc taaacagcgg ttggctttta gacattatat    240

atattatcag agaagtagcc tagtggtcgt ggggcacaga aaaaatagat aggggcagct    300

ctaaagacca gctgttaaga cagacaactg caaactcatt taagcaagag aaaaacagct    360

ctaattcgag attgtgaagc aacacttcta aattcaaaga catagagttg tcaaatcagg    420

attttttttt ttttaaatga tatcctttcg aatgtaactg attttgggaa aatcacatgt    480

tcagaattga ggctaaatgg tttgatcagg ttttctcttt gaagagacca cagccttagg    540

aaatggttct tgatctatac aattccacct tggacactgg gttaattctg tttgcccctg    600

gaacacaatc acgtaagttt ccttctagac tggcatcctg atgtgtcttg agtataatca    660

catgttgcta cctagtaaat aaaatcttaa gaagatccgt ggctttcctt caccagttca    720

tagcatcgtg attcattgcc cggattggac tcgactctac tcactggaca tctaaccact    780

ccacttaatt aacaataccc accctacagg ggtgttgtaa ggattaaaat ttaaaatacc    840

cgtgttttct acagtgcctg gctcaaaagc tactgcaagc tcgttactgc tcatcctcca    900

gaggcccaca tcaagtcagc cacgactcaa ggagactcca aagataaaag ctgaagccaa    960

aatatatgat tctaaacacc ctcctcggct actgcaaagc actgtgagca ctttctcagg   1020

acgagagcca agaagcccag cacctatggg tcaccacagt ttccgaggtc ccagatgaaa   1080

aagatgcgct cgctaccacc gtgcggcggt cctttctctc gcaatagtct caatgctccc   1140

gggccctgcc tccggacgcc aggacagagg taccaaaatc tcacctcctg caaagaaacc   1200

taattgctac gggggccgga agaggaagag gtgcggctcc gacagccaga ggggcgggca   1260

tacgcagcct ccctcggctc agcctgctac tggggatgca gagcgtcctg gtcgccatga   1320

aaacaggcca cacctcggcg atcccggccg gtggtttgca agtgcgcagg cgcgcgcccc   1380

cttccgcgca tgagcagtgc tgctcccaac ccgccagtcg cggtctccgg cgccagctac   1440

gccgctgccg ctgtcactat ggcccattac aaagccgccg actcgaagcg tgagcagttc   1500

cggaggtact tggagaagtc gggggtgctg gacacgctga ccaaggcatc acttaggagc   1560

tgctactcca gaaaatccag aaatagagct gcttcgccta gaactggccg aaatgaaaga   1620

gaagtatgaa gctattgtag aagaaaataa aaaactgaaa gcaaagcttg ctcagtatga   1680

accacctcag gaggagaagc gtgctgaata ggattcttct cagtttgaaa gacaatgaaa   1740

aatggttttg tatgacttga atagtttgta tagtatataa tcttttctga acagatgcta   1800

tagaactctt ttaatatgtt taattcacct atcacactct gttaaaaaca catagaatca   1860

tcaataaaaa ctcaatataa ctttc                                         1885


<210>  6178
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  6178

Met Ser Ser Ala Ala Pro Asn Pro Pro Val Ala Val Ser Gly Ala Ser 
1               5                   10                  15      


Tyr Ala Ala Ala Ala Val Thr Met Ala His Tyr Lys Ala Ala Asp Ser 
            20                  25                  30          


Lys Arg Glu Gln Phe Arg Arg Tyr Leu Glu Lys Ser Gly Val Leu Asp 
        35                  40                  45              


Thr Leu Thr Lys Ala Ser Leu Arg Ser Cys Tyr Ser Arg Lys Ser Arg 
    50                  55                  60                  


Asn Arg Ala Ala Ser Pro Arg Thr Gly Arg Asn Glu Arg Glu Val 
65                  70                  75                  


<210>  6179
<211>  421
<212>  DNA
<213>  Homosapiens

<400>  6179
cagatttacc taaactaaga aagtgttggt agccttatat gaagaaccag agaaacctaa     60

cagtgctttg gattttttaa agcatcactt aggagctgct actccagaaa atccagaaat    120

agagctgctt cgcctagaac tggccgaaat gaaagagaag tatgaagcta ttgtagaaga    180

aaataaaaaa ctgaaagcaa agcttgctca gtatgaacca cctcaggagg agaagcgtgc    240

tgaataggat tcttctcagt ttgaaagaca atgaaaaatg gttttgtatg acttgaatag    300

tttgtatagt atataatctt ttctgaacag atgctataga actcttttaa tatgtttaat    360

tcacctatca cactctgtta aaaacacata gaatcatcaa taaaaactca atataacttt    420

c                                                                    421


<210>  6180
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  6180

Met Lys Glu Lys Tyr Glu Ala Ile Val Glu Glu Asn Lys Lys Leu Lys 
1               5                   10                  15      


Ala Lys Leu Ala Gln Tyr Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
            20                  25                  30          


<210>  6181
<211>  3236
<212>  DNA
<213>  Homosapiens

<400>  6181
agaaagggac atggatttta gttgatggat gactcactca ctacattcaa ctgaactgaa     60

tctgctctat accagcaaag ggacaaattc agaaaataaa ttgaagatgg ccatgctgta    120

acttctaaac atggtttgct tctcagattt acctaaacta agaaaggttt gctttaagaa    180

atagtgctcc cttcagaatg gaagaattta tctgcctctt atttgatgtg gatcagagct    240

aagatggctg actaaataaa catgggggac tggaatctcc ttggagatac tctggaggaa    300

gttcacatcc actccaccat gattggaaag atctggctca ccatcctgtt catatttcga    360

atgcttgttc tgggtgtagc agctgaagat gtctggaatg atgagcagtc tggcttcatc    420

tgcaatacag aacaaccagg ctgcagaaat gtatgctacg accaggcctt tcctatctcc    480

ctcattagat actgggttct gcaggtgata tttgtgtctt caccatccct ggtctacatg    540

ggccatgcat tgtaccgact gagagttctt gaggaagaga ggcaaaggat gaaagctcag    600

ttaagagtag aactggagga ggtagagttt gaaatgccta gggatcggag gagattggag    660

caagagcttt gtcagctgga gaaaaggaaa ctaaataaag ctccactcag aggaaccttg    720

ctttgcactt atgtgataca cattttcact cgctctgtgg ttgaagttgg attcatgatt    780

ggacagtacc ttttatatgg atttcactta gagccgctat ttaagtgcca tggccacccg    840

tgtccaaata taatcgactg ttttgtctca agaccaacag aaaagacaat attcctatta    900

tttatgcaat ctatagccac tatttcactt ttcttaaaca ttcttgaaat tttccaccta    960

ggttttaaaa agattaaaag agggctttgg ggaaaataca agttgaagaa ggaacataat   1020

gaattccatg caaacaaggc aaaacaaaat gtagccaaat accagagcac atctgcaaat   1080

tcactgaagc gactcccttc tgcccctgat tataatctgt tagtggaaaa gcaaacacac   1140

actgcagtgt accctagttt aaattcatct tctgtattcc agccaaatcc tgacaatcat   1200

agtgtaaatg atgagaaatg cattttggat gaacaggaaa ctgtactttc taatgagatt   1260

tccacactta gtactagttg tagtcatttt caacacatca gttcaaacaa taacaaagac   1320

actcataaaa tatttggaaa agaacttaat ggtaaccagt taatggaaaa aagagaaact   1380

gaaggcaaag acagcaaaag gaactactac tctagaggtc accgttctat tccaggtgtt   1440

gctatagatg gagagaacaa catgaggcag tcaccccaaa cagttttctc cttgccagct   1500

aactgcgatt ggaaaccgcg gtggcttaga gctacatggg gttcctctac agaacatgaa   1560

aaccgggggt cacctcctaa aggtaacctc aagggccagt tcagaaaggg cacagtcaga   1620

acccttcctc cttcacaagg agattctcaa tcacttgaca ttccaaacac tgctgattct   1680

ttgggagggc tgtcctttga gccagggttg gtcagaacct gtaataatcc tgtttgtcct   1740

ccaaatcacg tagtgtccct aacgaacaat ctcattggta ggcgggttcc cacagatctt   1800

cagatctaaa cagcggttgg cttttagaca ttatatatat tatcagagaa gtagcctagt   1860

ggtcgtgggg cacagaaaaa atagataggg gcagctctaa agaccagctg ttaagacaga   1920

caactgcaaa ctcatttaag caagagaaaa acagctctaa ttcgagattg tgaagcaaca   1980

cttctaaatt caaagacata gagttgtcaa atcaggattt tttttttttt aaatgatatc   2040

ctttcgaatg taactgattt tgggaaaatc acatgttcag aattgaggct aaatggtttg   2100

atcaggtttt ctctttgaag agaccacagc cttaggaaat ggttcttgat ctatacaatt   2160

ccaccttgga cactgggtta attctgtttg cccctggaac acaatcacgt aagtttcctt   2220

ctagactggc atcctgatgt gtcttgagta taatcacatg ttgctaccta gtaaataaaa   2280

tcttaagaag atccgtggct ttccttcacc agttcatagc atcgtgattc attgcccgga   2340

ttggactcga ctctactcac tggacatcta accactccac ttaattaaca atacccaccc   2400

tacaggggtg ttgtaaggat taaaatttaa aatacccgtg ttttctacag tgcctggctc   2460

aaaagctact gcaagctcgt tactgctcat cctccagagg cccacatcaa gtcagccacg   2520

actcaaggag actccaaaga taaaagctga agccaaaata tatgattcta aacaccctcc   2580

tcggctactg caaagcactg tgagcacttt ctcaggacga gagccaagaa gcccagcacc   2640

tatgggtcac cacagtttcc gaggtcccag atgaaaaaga tgcgctcgct accaccgtgc   2700

ggcggtcctt tctctcgcaa tagtctcaat gctcccgggc cctgcctccg gacgccagga   2760

cagaggccgc cgactcgaag cgtgagcagt tccggaggta cttggagaag tcgggggtgc   2820

tggacacgct gaccaaggtg ttggtagcct tatatgaaga accagagaaa cctaacagtg   2880

ctttggattt tttaaagcat cacttaggag ctgctactcc agaaaatcca gaaatagagc   2940

tgcttcgcct agaactggcc gaaatgaaag agaagtatga agctattgta gaagaaaata   3000

aaaaactgaa agcaaagctt gctcagtatg aaccacctca ggaggagaag cgtgctgaat   3060

aggattcttc tcagtttgaa agacaatgaa aaatggtttt gtatgacttg aatagtttgt   3120

atagtatata atcttttctg aacagatgct atagaactct tttaatatgt ttaattcacc   3180

tatcacactc tgttaaaaac acatagaatc atcaataaaa actcaatata actttc       3236


<210>  6182
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6182

Met Lys Lys Met Arg Ser Leu Pro Pro Cys Gly Gly Pro Phe Ser Arg 
1               5                   10                  15      


Asn Ser Leu Asn Ala Pro Gly Pro Cys Leu Arg Thr Pro Gly Gln Arg 
            20                  25                  30          


Pro Pro Thr Arg Ser Val Ser Ser Ser Gly Gly Thr Trp Arg Ser Arg 
        35                  40                  45              


Gly Cys Trp Thr Arg 
    50              


<210>  6183
<211>  2397
<212>  DNA
<213>  Homosapiens

<400>  6183
atggtgctgt tttaaaagca aggataagca gaaagggaca tggattttag ttgatggatg     60

actcactcac tacattcaac tgaactgaat ctgctctata ccagcaaagg gacaaattca    120

gaaaataaat tgaagatggc catgctgtaa cttctaaaca tggtttgctt ctcagattta    180

cctaaactaa gaaaggtttg ctttaagaaa tagtgctccc ttcagaatgg aagaatttat    240

ctgcctctta tttgatgtgg atcagagcta agatggctga ctaaataaac atgggggact    300

ggaatctcct tggagatact ctggaggaag ttcacatcca ctccaccatg attggaaaga    360

tctggctcac catcctgttc atatttcgaa tgcttgttct gggtgtagca gctgaagatg    420

tctggaatga tgagcagtct ggcttcatct gcaatacaga acaaccaggc tgcagaaatg    480

tatgctacga ccaggccttt cctatctccc tcattagata ctgggttctg caggtgatat    540

ttgtgtcttc accatccctg gtctacatgg gccatgcatt gtaccgactg agagttcttg    600

aggaagagag gcaaaggatg aaagctcagt taagagtaga actggaggag gtagagtttg    660

aaatgcctag ggatcggagg agattggagc aagagctttg tcagctggag aaaaggaaac    720

taaataaagc tccactcaga ggaaccttgc tttgcactta tgtgatacac attttcactc    780

gctctgtggt tgaagttgga ttcatgattg gacagtacct tttatatgga tttcacttag    840

agccgctatt taagtgccat ggccacccgt gtccaaatat aatcgactgt tttgtctcaa    900

gaccaacaga aaagacaata ttcctattat ttatgcaatc tatagccact atttcacttt    960

tcttaaacat tcttgaaatt ttccacctag gttttaaaaa gattaaaaga gggctttggg   1020

gaaaatacaa gttgaagaag gaacataatg aattccatgc aaacaaggca aaacaaaatg   1080

tagccaaata ccagagcaca tctgcaaatt cactgaagcg actcccttct gcccctgatt   1140

ataatctgtt agtggaaaag caaacacaca ctgcagtgta ccctagttta aattcatctt   1200

ctgtattcca gccaaatcct gacaatcata gtgtaaatga tgagaaatgc attttggatg   1260

aacaggaaac tgtactttct aatgagattt ccacacttag tactagttgt agtcattttc   1320

aacacatcag ttcaaacaat aacaaagaca ctcataaaat atttggaaaa gaacttaatg   1380

gtaaccagtt aatggaaaaa agagaaactg aaggcaaaga cagcaaaagg aactactact   1440

ctagaggtca ccgttctatt ccaggtgttg ctatagatgg agagaacaac atgaggcagt   1500

caccccaaac agttttctcc ttgccagcta actgcgattg gaaaccgcgg tggcttagag   1560

ctacatgggg ttcctctaca gaacatgaaa accgggggtc acctcctaaa gtgcctggct   1620

caaaagctac tgcaagctcg ttactgctca tcctccagag gcccacatca agtcagccac   1680

gactcaagga gactccaaag ataaaagctg aagccaaaat atatgattct aaacaccctc   1740

ctcggctact gcaaagcact gtgagcactt tctcaggacg agagccaaga agcccagcac   1800

ctatgggtca ccacagtttc cgaggtccca gatgaaaaag atgcgctcgc taccaccgtg   1860

cggcggtcct ttctctcgca atagtctcaa tgctcccggg ccctgcctcc ggacgccagg   1920

acagaggccg ccgactcgaa gcgtgagcag ttccggaggt acttggagaa gtcgggggtg   1980

ctggacacgc tgaccaaggt gttggtagcc ttatatgaag aaccagagaa acctaacagt   2040

gctttggatt ttttaaagca tcacttagga gctgctactc cagaaaatcc agaaatagag   2100

ctgcttcgcc tagaactggc cgaaatgaaa gagaagtatg aagctattgt agaagaaaat   2160

aaaaaactga aagcaaagct tgctcagtat gaaccacctc aggaggagaa gcgtgctgaa   2220

taggattctt ctcagtttga aagacaatga aaaatggttt tgtatgactt gaatagtttg   2280

tatagtatat aatcttttct gaacagatgc tatagaactc ttttaatatg tttaattcac   2340

ctatcacact ctgttaaaaa cacatagaat catcaataaa aactcaatat aactttc      2397


<210>  6184
<211>  514
<212>  PRT
<213>  Homosapiens

<400>  6184

Met Gly Asp Trp Asn Leu Leu Gly Asp Thr Leu Glu Glu Val His Ile 
1               5                   10                  15      


His Ser Thr Met Ile Gly Lys Ile Trp Leu Thr Ile Leu Phe Ile Phe 
            20                  25                  30          


Arg Met Leu Val Leu Gly Val Ala Ala Glu Asp Val Trp Asn Asp Glu 
        35                  40                  45              


Gln Ser Gly Phe Ile Cys Asn Thr Glu Gln Pro Gly Cys Arg Asn Val 
    50                  55                  60                  


Cys Tyr Asp Gln Ala Phe Pro Ile Ser Leu Ile Arg Tyr Trp Val Leu 
65                  70                  75                  80  


Gln Val Ile Phe Val Ser Ser Pro Ser Leu Val Tyr Met Gly His Ala 
                85                  90                  95      


Leu Tyr Arg Leu Arg Val Leu Glu Glu Glu Arg Gln Arg Met Lys Ala 
            100                 105                 110         


Gln Leu Arg Val Glu Leu Glu Glu Val Glu Phe Glu Met Pro Arg Asp 
        115                 120                 125             


Arg Arg Arg Leu Glu Gln Glu Leu Cys Gln Leu Glu Lys Arg Lys Leu 
    130                 135                 140                 


Asn Lys Ala Pro Leu Arg Gly Thr Leu Leu Cys Thr Tyr Val Ile His 
145                 150                 155                 160 


Ile Phe Thr Arg Ser Val Val Glu Val Gly Phe Met Ile Gly Gln Tyr 
                165                 170                 175     


Leu Leu Tyr Gly Phe His Leu Glu Pro Leu Phe Lys Cys His Gly His 
            180                 185                 190         


Pro Cys Pro Asn Ile Ile Asp Cys Phe Val Ser Arg Pro Thr Glu Lys 
        195                 200                 205             


Thr Ile Phe Leu Leu Phe Met Gln Ser Ile Ala Thr Ile Ser Leu Phe 
    210                 215                 220                 


Leu Asn Ile Leu Glu Ile Phe His Leu Gly Phe Lys Lys Ile Lys Arg 
225                 230                 235                 240 


Gly Leu Trp Gly Lys Tyr Lys Leu Lys Lys Glu His Asn Glu Phe His 
                245                 250                 255     


Ala Asn Lys Ala Lys Gln Asn Val Ala Lys Tyr Gln Ser Thr Ser Ala 
            260                 265                 270         


Asn Ser Leu Lys Arg Leu Pro Ser Ala Pro Asp Tyr Asn Leu Leu Val 
        275                 280                 285             


Glu Lys Gln Thr His Thr Ala Val Tyr Pro Ser Leu Asn Ser Ser Ser 
    290                 295                 300                 


Val Phe Gln Pro Asn Pro Asp Asn His Ser Val Asn Asp Glu Lys Cys 
305                 310                 315                 320 


Ile Leu Asp Glu Gln Glu Thr Val Leu Ser Asn Glu Ile Ser Thr Leu 
                325                 330                 335     


Ser Thr Ser Cys Ser His Phe Gln His Ile Ser Ser Asn Asn Asn Lys 
            340                 345                 350         


Asp Thr His Lys Ile Phe Gly Lys Glu Leu Asn Gly Asn Gln Leu Met 
        355                 360                 365             


Glu Lys Arg Glu Thr Glu Gly Lys Asp Ser Lys Arg Asn Tyr Tyr Ser 
    370                 375                 380                 


Arg Gly His Arg Ser Ile Pro Gly Val Ala Ile Asp Gly Glu Asn Asn 
385                 390                 395                 400 


Met Arg Gln Ser Pro Gln Thr Val Phe Ser Leu Pro Ala Asn Cys Asp 
                405                 410                 415     


Trp Lys Pro Arg Trp Leu Arg Ala Thr Trp Gly Ser Ser Thr Glu His 
            420                 425                 430         


Glu Asn Arg Gly Ser Pro Pro Lys Val Pro Gly Ser Lys Ala Thr Ala 
        435                 440                 445             


Ser Ser Leu Leu Leu Ile Leu Gln Arg Pro Thr Ser Ser Gln Pro Arg 
    450                 455                 460                 


Leu Lys Glu Thr Pro Lys Ile Lys Ala Glu Ala Lys Ile Tyr Asp Ser 
465                 470                 475                 480 


Lys His Pro Pro Arg Leu Leu Gln Ser Thr Val Ser Thr Phe Ser Gly 
                485                 490                 495     


Arg Glu Pro Arg Ser Pro Ala Pro Met Gly His His Ser Phe Arg Gly 
            500                 505                 510         


Pro Arg 
        


<210>  6185
<211>  430
<212>  DNA
<213>  Homosapiens

<400>  6185
ctatgaagta gctgagtgag cctaatcccc aaatgttggt agccttatat gaagaaccag     60

agaaacctaa cagtgctttg gattttttaa agcatcactt aggagctgct actccagaaa    120

atccagaaat agagctgctt cgcctagaac tggccgaaat gaaagagaag tatgaagcta    180

ttgtagaaga aaataaaaaa ctgaaagcaa agcttgctca gtatgaacca cctcaggagg    240

agaagcgtgc tgaataggat tcttctcagt ttgaaagaca atgaaaaatg gttttgtatg    300

acttgaatag tttgtatagt atataatctt ttctgaacag atgctataga actcttttaa    360

tatgtttaat tcacctatca cactctgtta aaaacacata gaatcatcaa taaaaactca    420

atataacttt                                                           430


<210>  6186
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  6186

Met Leu Val Ala Leu Tyr Glu Glu Pro Glu Lys Pro Asn Ser Ala Leu 
1               5                   10                  15      


Asp Phe Leu Lys His His Leu Gly Ala Ala Thr Pro Glu Asn Pro Glu 
            20                  25                  30          


Ile Glu Leu Leu Arg Leu Glu Leu Ala Glu Met Lys Glu Lys Tyr Glu 
        35                  40                  45              


Ala Ile Val Glu Glu Asn Lys Lys Leu Lys Ala Lys Leu Ala Gln Tyr 
    50                  55                  60                  


Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
65                  70                  


<210>  6187
<211>  453
<212>  DNA
<213>  Homosapiens

<400>  6187
cactgacccc cggtgtctct tcaggccgcc gactcgaagc gtgagcagtt ccggagtgtt     60

ggtagcctta tatgaagaac cagagaaacc taacagtgct ttggattttt taaagcatca    120

cttaggagct gctactccag aaaatccaga aatagagctg cttcgcctag aactggccga    180

aatgaaagag aagtatgaag ctattgtaga agaaaataaa aaactgaaag caaagcttgc    240

tcagtatgaa ccacctcagg aggagaagcg tgctgaatag gattcttctc agtttgaaag    300

acaatgaaaa atggttttgt atgacttgaa tagtttgtat agtatataat cttttctgaa    360

cagatgctat agaactcttt taatatgttt aattcaccta tcacactctg ttaaaaacac    420

atagaatcat caataaaaac tcaatataac ttt                                 453


<210>  6188
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  6188

Met Lys Glu Lys Tyr Glu Ala Ile Val Glu Glu Asn Lys Lys Leu Lys 
1               5                   10                  15      


Ala Lys Leu Ala Gln Tyr Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
            20                  25                  30          


<210>  6189
<211>  558
<212>  DNA
<213>  Homosapiens

<400>  6189
tgaggcggag gcggggttgc cggactccca gcgccttctt cctgctcggc tcccgggctc     60

tggccactga cccccggtgt ctcttcaggc cgccgactcg aagcgtgagc agttccggag    120

gtacttggag aagtcggggg tgctggacac gctgaccaag gtgttggtag ccttatatga    180

agaaccagag aaacctaaca gtgctttgga ttttttaaag catcacttag gagctgctac    240

tccagaaaat ccagaaatag agctgcttcg cctagaactg gccgaaatga aagagaagta    300

tgaagctatt gtagaagaaa ataaaaaact gaaagcaaag cttgctcagt atgaaccacc    360

tcaggaggag aagcgtgctg aataggattc ttctcagttt gaaagacaat gaaaaatggt    420

tttgtatgac ttgaatagtt tgtatagtat ataatctttt ctgaacagat gctatagaac    480

tcttttaata tgtttaattc acctatcaca ctctgttaaa aacacataga atcatcaata    540

aaaactcaat ataacttt                                                  558


<210>  6190
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  6190

Met Lys Glu Lys Tyr Glu Ala Ile Val Glu Glu Asn Lys Lys Leu Lys 
1               5                   10                  15      


Ala Lys Leu Ala Gln Tyr Glu Pro Pro Gln Glu Glu Lys Arg Ala Glu 
            20                  25                  30          


<210>  6191
<211>  418
<212>  DNA
<213>  Homosapiens

<400>  6191
cgaccaggac gctctgcatc cccagtagca ggctgagccg agggaggctg cgtatgcccg     60

cccctctggc tgtcggagcc gcacctcttc ctcttccggc ccccgtagca attaggtttc    120

tttgcaggag atgaagccag actgctcatc attccagaca tcttcagctg ctacacccag    180

aacaagcatt cgaaatatga acaggatggt gagccagatc tttccaatca tggtggagtg    240

gatgtgaact tcctccagag tatctccaag gagattccag tcccccatgt ttatttagtc    300

agccatctta gctctgatcc acatcaaata agaggcagat aaattcttcc attctgaagg    360

gagcactatt tcttaaagca aacctatggt gaaaatataa caatatgtca cttctata      418


<210>  6192
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  6192

Met Lys Pro Asp Cys Ser Ser Phe Gln Thr Ser Ser Ala Ala Thr Pro 
1               5                   10                  15      


Arg Thr Ser Ile Arg Asn Met Asn Arg Met Val Ser Gln Ile Phe Pro 
            20                  25                  30          


Ile Met Val Glu Trp Met 
        35              


<210>  6193
<211>  1901
<212>  DNA
<213>  Homosapiens

<400>  6193
cagggagttg tggttgcaac actgtactcc agcctgggca acagagggag actctgtctc     60

aacaaacaaa caaacaaaga aaaaacccca cagctatcta gggaaaaagt aaagcaacca    120

gcatatagaa gtgacatatt gttatatttt caccataggt ttgctttaag aaatagtgct    180

cccttcagaa tggaagaatt tatctgcctc ttatttgatg tggatcagag ctaagatggc    240

tgactaaata aacatggggg actggaatct ccttggagat actctggagg aagttcacat    300

ccactccacc atgattggaa agatctggct caccatcctg ttcatatttc gaatgcttgt    360

tctgggtgta gcagctgaag atgtctggaa tgatgagcag tctggcttca tctgcaatac    420

agaacaacca ggctgcagaa atgtatgcta cgaccaggcc tttcctatct ccctcattag    480

atactgggtt ctgcaggtga tatttgtgtc ttcaccatcc ctggtctaca tgggccatgc    540

attgtaccga ctgagagttc ttgaggaaga gaggcaaagg atgaaagctc agttaagagt    600

agaactggag gaggtagagt ttgaaatgcc tagggatcgg aggagattgg agcaagagct    660

ttgtcagctg gagaaaagga aactaaataa agctccactc agaggaacct tgctttgcac    720

ttatgtgata cacattttca ctcgctctgt ggttgaagtt ggattcatga ttggacagta    780

ccttttatat ggatttcact tagagccgct atttaagtgc catggccacc cgtgtccaaa    840

tataatcgac tgttttgtct caagaccaac agaaaagaca atattcctat tatttatgca    900

atctatagcc actatttcac ttttcttaaa cattcttgaa attttccacc taggttttaa    960

aaagattaaa agagggcttt ggggaaaata caagttgaag aaggaacata atgaattcca   1020

tgcaaacaag gcaaaacaaa atgtagccaa ataccagagc acatctgcaa attcactgaa   1080

gcgactccct tctgcccctg attataatct gttagtggaa aagcaaacac acactgcagt   1140

gtaccctagt ttaaattcat cttctgtatt ccagccaaat cctgacaatc atagtgtaaa   1200

tgatgagaaa tgcattttgg atgaacagga aactgtactt tctaatgaga tttccacact   1260

tagtactagt tgtagtcatt ttcaacacat cagttcaaac aataacaaag acactcataa   1320

aatatttgga aaagaactta atggtaacca gttaatggaa aaaagagaaa ctgaaggcaa   1380

agacagcaaa aggaactact actctagagg tcaccgttct attccaggtg ttgctataga   1440

tggagagaac aacatgaggc agtcacccca aacagttttc tccttgccag ctaactgcga   1500

ttggaaaccg cggtggctta gagctacatg gggttcctct acagaacatg aaaaccgggg   1560

gtcacctcct aaaggtaacc tcaagggcca gttcagaaag ggcacagtca gaacccttcc   1620

tccttcacaa ggagattctc aatcacttga cattccaaac actgctgatt ctttgggagg   1680

gctgtccttt gagccagggt tggtcagaac ctgtaataat cctgtttgtc ctccaaatca   1740

cgtagtgtcc ctaacgaaca atctcattgg taggcgggtt cccacagatc ttcagatcta   1800

aacagcggtt ggcttttaga cattatatat attatcagag aagtagccta gtggtcgtgg   1860

ggcacagaaa aaatagatag gggcagctct aaagaccagc t                       1901


<210>  6194
<211>  515
<212>  PRT
<213>  Homosapiens

<400>  6194

Met Gly Asp Trp Asn Leu Leu Gly Asp Thr Leu Glu Glu Val His Ile 
1               5                   10                  15      


His Ser Thr Met Ile Gly Lys Ile Trp Leu Thr Ile Leu Phe Ile Phe 
            20                  25                  30          


Arg Met Leu Val Leu Gly Val Ala Ala Glu Asp Val Trp Asn Asp Glu 
        35                  40                  45              


Gln Ser Gly Phe Ile Cys Asn Thr Glu Gln Pro Gly Cys Arg Asn Val 
    50                  55                  60                  


Cys Tyr Asp Gln Ala Phe Pro Ile Ser Leu Ile Arg Tyr Trp Val Leu 
65                  70                  75                  80  


Gln Val Ile Phe Val Ser Ser Pro Ser Leu Val Tyr Met Gly His Ala 
                85                  90                  95      


Leu Tyr Arg Leu Arg Val Leu Glu Glu Glu Arg Gln Arg Met Lys Ala 
            100                 105                 110         


Gln Leu Arg Val Glu Leu Glu Glu Val Glu Phe Glu Met Pro Arg Asp 
        115                 120                 125             


Arg Arg Arg Leu Glu Gln Glu Leu Cys Gln Leu Glu Lys Arg Lys Leu 
    130                 135                 140                 


Asn Lys Ala Pro Leu Arg Gly Thr Leu Leu Cys Thr Tyr Val Ile His 
145                 150                 155                 160 


Ile Phe Thr Arg Ser Val Val Glu Val Gly Phe Met Ile Gly Gln Tyr 
                165                 170                 175     


Leu Leu Tyr Gly Phe His Leu Glu Pro Leu Phe Lys Cys His Gly His 
            180                 185                 190         


Pro Cys Pro Asn Ile Ile Asp Cys Phe Val Ser Arg Pro Thr Glu Lys 
        195                 200                 205             


Thr Ile Phe Leu Leu Phe Met Gln Ser Ile Ala Thr Ile Ser Leu Phe 
    210                 215                 220                 


Leu Asn Ile Leu Glu Ile Phe His Leu Gly Phe Lys Lys Ile Lys Arg 
225                 230                 235                 240 


Gly Leu Trp Gly Lys Tyr Lys Leu Lys Lys Glu His Asn Glu Phe His 
                245                 250                 255     


Ala Asn Lys Ala Lys Gln Asn Val Ala Lys Tyr Gln Ser Thr Ser Ala 
            260                 265                 270         


Asn Ser Leu Lys Arg Leu Pro Ser Ala Pro Asp Tyr Asn Leu Leu Val 
        275                 280                 285             


Glu Lys Gln Thr His Thr Ala Val Tyr Pro Ser Leu Asn Ser Ser Ser 
    290                 295                 300                 


Val Phe Gln Pro Asn Pro Asp Asn His Ser Val Asn Asp Glu Lys Cys 
305                 310                 315                 320 


Ile Leu Asp Glu Gln Glu Thr Val Leu Ser Asn Glu Ile Ser Thr Leu 
                325                 330                 335     


Ser Thr Ser Cys Ser His Phe Gln His Ile Ser Ser Asn Asn Asn Lys 
            340                 345                 350         


Asp Thr His Lys Ile Phe Gly Lys Glu Leu Asn Gly Asn Gln Leu Met 
        355                 360                 365             


Glu Lys Arg Glu Thr Glu Gly Lys Asp Ser Lys Arg Asn Tyr Tyr Ser 
    370                 375                 380                 


Arg Gly His Arg Ser Ile Pro Gly Val Ala Ile Asp Gly Glu Asn Asn 
385                 390                 395                 400 


Met Arg Gln Ser Pro Gln Thr Val Phe Ser Leu Pro Ala Asn Cys Asp 
                405                 410                 415     


Trp Lys Pro Arg Trp Leu Arg Ala Thr Trp Gly Ser Ser Thr Glu His 
            420                 425                 430         


Glu Asn Arg Gly Ser Pro Pro Lys Gly Asn Leu Lys Gly Gln Phe Arg 
        435                 440                 445             


Lys Gly Thr Val Arg Thr Leu Pro Pro Ser Gln Gly Asp Ser Gln Ser 
    450                 455                 460                 


Leu Asp Ile Pro Asn Thr Ala Asp Ser Leu Gly Gly Leu Ser Phe Glu 
465                 470                 475                 480 


Pro Gly Leu Val Arg Thr Cys Asn Asn Pro Val Cys Pro Pro Asn His 
                485                 490                 495     


Val Val Ser Leu Thr Asn Asn Leu Ile Gly Arg Arg Val Pro Thr Asp 
            500                 505                 510         


Leu Gln Ile 
        515 


<210>  6195
<211>  2301
<212>  DNA
<213>  Homosapiens

<400>  6195
tttgaactcc tgacctcaag tgatctacct gccttggcct tccaaagtgc tgagattaca     60

ggcctgaacc actgctccag gccataaata ctttttagat ttgttctgta actcagttat    120

gttacttgaa agcagtttga ttctttttgg taagatggta attattccca ccactggacc    180

cttttgtgta ctctgagcat tgccccatta attatggcat tttccagtac acatccccac    240

actgcttgca ggaaaggacc tagagaaaag tcgcagggca gaaaagcaga ggaggacggc    300

cctggatttg gcttatcagt ccttggggcc ctcctgcccc aggaagggca gcgaggacca    360

tggtgttgct gccatcatta tcaccctggc catgagattg caggactggg gcagacccag    420

aggaggactg gaagggccag agtcagccag gaacacagca gctcagctct cggctgttgg    480

caggtggcct tgatggcttt tcaaaggcaa tcactccacc caggacaaag ctcacttttc    540

tctggggcaa aacacattgg ttcatttgtt cagttcatta attcaaccag tctgtttcta    600

agggaaacct ggctgtggcc agtcctgctc ccacatccct aggtgcccag tgttcccaag    660

ggacctgaat tccaacccca gttaggagtt caggggtcag catccccatg ccccacatgc    720

ctgttaggga ggacagtgaa ggctgagcac tcttgggctc accaaacacc agcattgaga    780

aactgccccc catcttccct aggtaaggtg accttgtagg acagttcatg ctattgggat    840

ggtctgggta aggtggccac gagggcaggg gaccaaggtc tgccccacct ttgaccttag    900

cgacatgccc ctgattgcct ggcccccctc tggttgtcgt ctgagtccct tctctggggg    960

tacctgggcc ttgctgcact tcctttgtat gctaacttca tcctgatcaa acttgatttt   1020

cctactgtga tttctttcca atttcttcat caagttaaaa attctgtatt gagagcagtt   1080

tcctacatta cctcaaatcc tgttcaaaca aggattatcc ctagaagtca gaaaggaggg   1140

aaaacaagct tagtcacaga agactactct atacttgagc ttctgtttca agggaagtga   1200

gtaactggtg gtggagccct gcccctctgc agtgtgtggt tttgtcctga tatattttaa   1260

gattgagatg taactcacct gtcataaaat gcccagactt atgatgtgtg gaaacaaaag   1320

agttttccag tacagaaagt tacttagcct ctctggtgct gtgtaagcaa caggtagtct   1380

tcccacttca tttttggtgg ttctttcctt ggcttgggta atttccttgc atgctccttt   1440

ctggagtttt ctgtatgcag ctttctgctc tctggtaccc tgtcttgtaa actctagcag   1500

tccagatcta tctggactct aaacttcatc tcatcaactt aaagtttgct gagatctgcc   1560

tgggttcctg cttcatgcgc tgtattctgt aatctccctc aaggtagtac ctgggcaatc   1620

agataactca tctattaata actgattccc tgtctctaag ggtttactgg ttttgttttc   1680

tgatgtctag tatcttgaag accattcttt cctatatgtt gtccagtgct tttggctttt   1740

tcaagtgaga cagcaaatcc tattcttgtg accttatcat ggtcagaagt agacatttgt   1800

atctatttta aaaataaatt tctcatatga ttatgatata atcaccccag ccctagtcta   1860

taggttagca tttgagaatc attgctctaa gttgctctgg actacttctt tgttttttga   1920

gacagagtct cattctgtca ccaggctgga gtgcagtggt gcgatctcag ctccctgcaa   1980

cctctgcctc ccaggttcaa gtgatcctcg tgcctcagac tccccagtag ttggaattat   2040

aggcatgtgc caccacagcc agctaatttt attttttttc aatttttttg agacagagtc   2100

tcacttccag cctgggtgac agagcgacac tcggtctcaa aaaacaaaac aaaacaaaac   2160

aaaattagag attgggtctt tcccaggcat atggtattct ataaaacaga cttactctcc   2220

ttggaggata tattttggag aatgcttcat aaaatctatg aatactgtac aatgctgata   2280

ataaaaactt tttatacctg t                                             2301


<210>  6196
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  6196

Met Ala Phe Ser Ser Thr His Pro His Thr Ala Cys Arg Lys Gly Pro 
1               5                   10                  15      


Arg Glu Lys Ser Gln Gly Arg Lys Ala Glu Glu Asp Gly Pro Gly Phe 
            20                  25                  30          


Gly Leu Ser Val Leu Gly Ala Leu Leu Pro Gln Glu Gly Gln Arg Gly 
        35                  40                  45              


Pro Trp Cys Cys Cys His His Tyr His Pro Gly His Glu Ile Ala Gly 
    50                  55                  60                  


Leu Gly Gln Thr Gln Arg Arg Thr Gly Arg Ala Arg Val Ser Gln Glu 
65                  70                  75                  80  


His Ser Ser Ser Ala Leu Gly Cys Trp Gln Val Ala Leu Met Ala Phe 
                85                  90                  95      


Gln Arg Gln Ser Leu His Pro Gly Gln Ser Ser Leu Phe Ser Gly Ala 
            100                 105                 110         


Lys His Ile Gly Ser Phe Val Gln Phe Ile Asn Ser Thr Ser Leu Phe 
        115                 120                 125             


Leu Arg Glu Thr Trp Leu Trp Pro Val Leu Leu Pro His Pro 
    130                 135                 140         


<210>  6197
<211>  2619
<212>  DNA
<213>  Homosapiens

<400>  6197
gatagggtct cgctttatca ctcaggatgg agtgtagtgc cacgatcttg gctcactgca     60

acctccacct cccgggttca agcgattctc ctgcctcagc atccccagta gctgggatta    120

aaggcatctg ccacctcacc tggctaattt tttgggtact tttcgtagag atggggtttt    180

accatgttgg tcaggctggt ctcgaatgcc cgacctcagg tgatccgccc gcctctgcct    240

cccaaagtgc tgggattata ggcgtgagcc accgcgccct gcccgagtca ggttttttta    300

ttgcaaaaga tgggaactga ttctggctaa ttaaatcagg aaatgaattt tattgaaagc    360

acattgagta agttacagaa tcacttgaag gctgtagaaa caaggcttgg gaaaaaagca    420

gaaacagaga ccaggtacct agaattacac caaattccat cacagagcca gataggtgag    480

gacagcctca gtgctgctgc tgctgaacgc ccagtgctgc tgcctttgtc acagccacag    540

ctggcgttgg atgctggatg ccatgctgac cccagtggca aggcgtctgg acactggata    600

ctgctgccac tgctgcaacc actgtaaaga attttttcca tcctcacctc cagcctcaga    660

aatcctaagc aaatgcagct gattggtcaa gctgccctag ctgcctaggg acatgcaaaa    720

gtgaatattg ggcatggtta atgtctgtag tgggatccgt ttcctgctgc ccaccaggag    780

aagataaatt ccccaagaaa actgacaaat gacgactacg tacatgttgt caaagaatcc    840

actggaagtc tttgacattt gcagattcaa cacttgcaat tttggaaagg ccttggaaag    900

cagtcgttgc gccagacagc ccagggaaga gcggcagcct gaggacctag ggccacctgc    960

tgttccctgg gattcatgtc cttctgggga ggagggagga cccaggacaa tggctgctgt   1020

tcatgatctg gagatggaga gcatgaatct gaatatgggg agagagatga aagaagagct   1080

ggaggaagag gagaaaatga gagaggatgg gggaggtaaa gatcgggcca agagtaaaaa   1140

ggtccacagg attgtctcaa aatggatgct gcccgaaaag tcccgaggaa catacttgga   1200

gagagctaac tgcttcccgc ctcccgtgtt catcatctcc atcagcctgg ccgagctggc   1260

agtgtttatt tactatgctg tgtggaagcc tcagaaacag tggatcacgt tggacacagg   1320

catcttggag agtcccttta tctacagtcc tgagaagagg gaggaagcct ggaggtttat   1380

ctcatacatg ctggtacatg ctggagttca gcacatcttg gggaatcttt gtatgcagct   1440

tgttttgggt attcccttgg aaatggtcca caaaggcctc cgtgtggggc tggtgtacct   1500

ggcaggagtg attgcagggt cccttgccag ctccatcttt gacccactca gatatcttgt   1560

gggagcttca ggaggagtct atgctctgat gggaggctat tttatgaatg ttctggtgaa   1620

ttttcaagaa atgattcctg cctttggaat tttcagactg ctgatcatca tcctgataat   1680

tgtgttggac atgggatttg ctctctatag aaggttcttt gttcctgaag atgggtctcc   1740

ggtgtctttt gcagctcaca ttgcaggtgg atttgctgga atgtccattg gctacacggt   1800

gtttagctgc tttgataaag cactgctgaa agatccaagg ttttggatag caattgctgc   1860

atatttagct tgtgtcttat ttgctgtgtt tttcaacatt ttcctatctc cagcaaactg   1920

acctgcccct attgtaagtc aattaataaa aagagccatc tggaggaaat aaaaaaaaaa   1980

ggaagactct atgaagaaac agagaagtct cagaaaaggc taacaatttt atatagagga   2040

caaaacagca ttaaactcat cagttgcaaa gattgcctat aaaaggacct taggatttaa   2100

ggaaggggct tcttaatgta gaaagggaag aagaagagag aaaagaaggg tagtaaaaac   2160

tagagattgg ggccaggcgc agtggctcac gcctgtaatc ccagcacttt gggaggctga   2220

ggcgggtgaa atcacctgag gtcatgagtt caagaccagc ctgaccaata tggtgaaacc   2280

ctgtctctac taaagaaaat acaaaaatta gccgggcgtg gtggcgtgtg cctgtagtcc   2340

cagctacttg cgaggctgag gcaggagaat tgcttgaacc tgggaggcga aggttgcagt   2400

gagccgagat tgcgccactg cactccagcc tgggtgacag agcgacactc ggtctcaaaa   2460

aacaaaacaa aacaaaacaa aattagagat tgggtctttc ccaggcatat ggtattctat   2520

aaaacagact tactctcctt ggaggatata ttttggagaa tgcttcataa aatctatgaa   2580

tactgtacaa tgctgataat aaaaactttt tatacctgt                          2619


<210>  6198
<211>  370
<212>  PRT
<213>  Homosapiens

<400>  6198

Met Thr Thr Thr Tyr Met Leu Ser Lys Asn Pro Leu Glu Val Phe Asp 
1               5                   10                  15      


Ile Cys Arg Phe Asn Thr Cys Asn Phe Gly Lys Ala Leu Glu Ser Ser 
            20                  25                  30          


Arg Cys Ala Arg Gln Pro Arg Glu Glu Arg Gln Pro Glu Asp Leu Gly 
        35                  40                  45              


Pro Pro Ala Val Pro Trp Asp Ser Cys Pro Ser Gly Glu Glu Gly Gly 
    50                  55                  60                  


Pro Arg Thr Met Ala Ala Val His Asp Leu Glu Met Glu Ser Met Asn 
65                  70                  75                  80  


Leu Asn Met Gly Arg Glu Met Lys Glu Glu Leu Glu Glu Glu Glu Lys 
                85                  90                  95      


Met Arg Glu Asp Gly Gly Gly Lys Asp Arg Ala Lys Ser Lys Lys Val 
            100                 105                 110         


His Arg Ile Val Ser Lys Trp Met Leu Pro Glu Lys Ser Arg Gly Thr 
        115                 120                 125             


Tyr Leu Glu Arg Ala Asn Cys Phe Pro Pro Pro Val Phe Ile Ile Ser 
    130                 135                 140                 


Ile Ser Leu Ala Glu Leu Ala Val Phe Ile Tyr Tyr Ala Val Trp Lys 
145                 150                 155                 160 


Pro Gln Lys Gln Trp Ile Thr Leu Asp Thr Gly Ile Leu Glu Ser Pro 
                165                 170                 175     


Phe Ile Tyr Ser Pro Glu Lys Arg Glu Glu Ala Trp Arg Phe Ile Ser 
            180                 185                 190         


Tyr Met Leu Val His Ala Gly Val Gln His Ile Leu Gly Asn Leu Cys 
        195                 200                 205             


Met Gln Leu Val Leu Gly Ile Pro Leu Glu Met Val His Lys Gly Leu 
    210                 215                 220                 


Arg Val Gly Leu Val Tyr Leu Ala Gly Val Ile Ala Gly Ser Leu Ala 
225                 230                 235                 240 


Ser Ser Ile Phe Asp Pro Leu Arg Tyr Leu Val Gly Ala Ser Gly Gly 
                245                 250                 255     


Val Tyr Ala Leu Met Gly Gly Tyr Phe Met Asn Val Leu Val Asn Phe 
            260                 265                 270         


Gln Glu Met Ile Pro Ala Phe Gly Ile Phe Arg Leu Leu Ile Ile Ile 
        275                 280                 285             


Leu Ile Ile Val Leu Asp Met Gly Phe Ala Leu Tyr Arg Arg Phe Phe 
    290                 295                 300                 


Val Pro Glu Asp Gly Ser Pro Val Ser Phe Ala Ala His Ile Ala Gly 
305                 310                 315                 320 


Gly Phe Ala Gly Met Ser Ile Gly Tyr Thr Val Phe Ser Cys Phe Asp 
                325                 330                 335     


Lys Ala Leu Leu Lys Asp Pro Arg Phe Trp Ile Ala Ile Ala Ala Tyr 
            340                 345                 350         


Leu Ala Cys Val Leu Phe Ala Val Phe Phe Asn Ile Phe Leu Ser Pro 
        355                 360                 365             


Ala Asn 
    370 


<210>  6199
<211>  1842
<212>  DNA
<213>  Homosapiens

<400>  6199
aggcaagcgg cacaagctca caactaaaag tgtctgccat ggaaaaggag ttgtcataag     60

ggtgttggcc ttgccagggc cttcctgggt gaggcgaaga agggaaggaa aggccttgga    120

aagcagtcgt tgcgccagac agcccaggga agagcggcag cctgaggacc tagggccacc    180

tgctgttccc tgggattcat gtccttctgg ggaggaggga ggacccagga caatggctgc    240

tgttcatgat ctggagatgg agagcatgaa tctgaatatg gggagagaga tgaaagaaga    300

gctggaggaa gaggagaaaa tgagagagga tgggggaggt aaagatcggg ccaagagtaa    360

aaaggtccac aggattgtct caaaatggat gctgcccgaa aagtcccgag gaacatactt    420

ggagagagct aactgcttcc cgcctcccgt gttcatcatc tccatcagcc tggccgagct    480

ggcagtgttt atttactatg ctgtgtggaa gcctcagaaa cagtggatca cgttggacac    540

aggcatcttg gagagtccct ttatctacag tcctgagaag agggaggaag cctggaggtt    600

tatctcatac atgctggtac atgctggagt tcagcacatc ttggggaatc tttgtatgca    660

gcttgttttg ggtattccct tggaaatggt ccacaaaggc ctccgtgtgg ggctggtgta    720

cctggcagga gtgattgcag ggtcccttgc cagctccatc tttgacccac tcagatatct    780

tgtgggagct tcaggaggag tctatgctct gatgggaggc tattttatga atgttctggt    840

gaattttcaa gaaatgattc ctgcctttgg aattttcaga ctgctgatca tcatcctgat    900

aattgtgttg gacatgggat ttgctctcta tagaaggttc tttgttcctg aagatgggtc    960

tccggtgtct tttgcagctc acattgcagg tggatttgct ggaatgtcca ttggctacac   1020

ggtgtttagc tgctttgata aagcactgct gaaagatcca aggttttgga tagcaattgc   1080

tgcatattta gcttgtgtct tatttgctgt gtttttcaac attttcctat ctccagcaaa   1140

ctgacctgcc cctattgtaa gtcaattaat aaaaagagcc atctggagga aataaaaaaa   1200

aaaggaagac tctatgaaga aacagagaag tctcagaaaa ggctaacaat tttatataga   1260

ggacaaaaca gcattaaact catcagttgc aaagattgcc tataaaagga ccttaggatt   1320

taaggaaggg gcttcttaat gtagaaaggg aagaagaaga gagaaaagaa gggtagtaaa   1380

aactagagat tggggccagg cgcagtggct cacgcctgta atcccagcac tttgggaggc   1440

tgaggcgggt gaaatcacct gaggtcatga gttcaagacc agcctgacca atatggtgaa   1500

accctgtctc tactaaagaa aatacaaaaa ttagccgggc gtggtggcgt gtgcctgtag   1560

tcccagctac ttgcgaggct gaggcaggag aattgcttga acctgggagg cgaaggttgc   1620

agtgagccga gattgcgcca ctgcactcca gcctgggtga cagagcgaca ctcggtctca   1680

aaaaacaaaa caaaacaaaa caaaattaga gattgggtct ttcccaggca tatggtattc   1740

tataaaacag acttactctc cttggaggat atattttgga gaatgcttca taaaatctat   1800

gaatactgta caatgctgat aataaaaact ttttatacct gt                      1842


<210>  6200
<211>  303
<212>  PRT
<213>  Homosapiens

<400>  6200

Met Ala Ala Val His Asp Leu Glu Met Glu Ser Met Asn Leu Asn Met 
1               5                   10                  15      


Gly Arg Glu Met Lys Glu Glu Leu Glu Glu Glu Glu Lys Met Arg Glu 
            20                  25                  30          


Asp Gly Gly Gly Lys Asp Arg Ala Lys Ser Lys Lys Val His Arg Ile 
        35                  40                  45              


Val Ser Lys Trp Met Leu Pro Glu Lys Ser Arg Gly Thr Tyr Leu Glu 
    50                  55                  60                  


Arg Ala Asn Cys Phe Pro Pro Pro Val Phe Ile Ile Ser Ile Ser Leu 
65                  70                  75                  80  


Ala Glu Leu Ala Val Phe Ile Tyr Tyr Ala Val Trp Lys Pro Gln Lys 
                85                  90                  95      


Gln Trp Ile Thr Leu Asp Thr Gly Ile Leu Glu Ser Pro Phe Ile Tyr 
            100                 105                 110         


Ser Pro Glu Lys Arg Glu Glu Ala Trp Arg Phe Ile Ser Tyr Met Leu 
        115                 120                 125             


Val His Ala Gly Val Gln His Ile Leu Gly Asn Leu Cys Met Gln Leu 
    130                 135                 140                 


Val Leu Gly Ile Pro Leu Glu Met Val His Lys Gly Leu Arg Val Gly 
145                 150                 155                 160 


Leu Val Tyr Leu Ala Gly Val Ile Ala Gly Ser Leu Ala Ser Ser Ile 
                165                 170                 175     


Phe Asp Pro Leu Arg Tyr Leu Val Gly Ala Ser Gly Gly Val Tyr Ala 
            180                 185                 190         


Leu Met Gly Gly Tyr Phe Met Asn Val Leu Val Asn Phe Gln Glu Met 
        195                 200                 205             


Ile Pro Ala Phe Gly Ile Phe Arg Leu Leu Ile Ile Ile Leu Ile Ile 
    210                 215                 220                 


Val Leu Asp Met Gly Phe Ala Leu Tyr Arg Arg Phe Phe Val Pro Glu 
225                 230                 235                 240 


Asp Gly Ser Pro Val Ser Phe Ala Ala His Ile Ala Gly Gly Phe Ala 
                245                 250                 255     


Gly Met Ser Ile Gly Tyr Thr Val Phe Ser Cys Phe Asp Lys Ala Leu 
            260                 265                 270         


Leu Lys Asp Pro Arg Phe Trp Ile Ala Ile Ala Ala Tyr Leu Ala Cys 
        275                 280                 285             


Val Leu Phe Ala Val Phe Phe Asn Ile Phe Leu Ser Pro Ala Asn 
    290                 295                 300             


<210>  6201
<211>  1830
<212>  DNA
<213>  Homosapiens

<400>  6201
atcttcaggg cagcgggcaa ccccttggcc caggaagcct ggaacgcaag gaccggaggg     60

cgtgggctgg gacgccccta ccttggtctt tcagggaaag gccttggaaa gcagtcgttg    120

cgccagacag cccagggaag agcggcagcc tgaggaccta gggccacctg ctgttccctg    180

ggattcatgt ccttctgggg aggagggagg acccaggaca atggctgctg ttcatgatct    240

ggagatggag agcatgaatc tgaatatggg gagagagatg aaagaagagc tggaggaaga    300

ggagaaaatg agagaggatg ggggaggtaa agatcgggcc aagagtaaaa aggtccacag    360

gattgtctca aaatggatgc tgcccgaaaa gtcccgagga acatacttgg agagagctaa    420

ctgcttcccg cctcccgtgt tcatcatctc catcagcctg gccgagctgg cagtgtttat    480

ttactatgct gtgtggaagc ctcagaaaca gtggatcacg ttggacacag gcatcttgga    540

gagtcccttt atctacagtc ctgagaagag ggaggaagcc tggaggttta tctcatacat    600

gctggtacat gctggagttc agcacatctt ggggaatctt tgtatgcagc ttgttttggg    660

tattcccttg gaaatggtcc acaaaggcct ccgtgtgggg ctggtgtacc tggcaggagt    720

gattgcaggg tcccttgcca gctccatctt tgacccactc agatatcttg tgggagcttc    780

aggaggagtc tatgctctga tgggaggcta ttttatgaat gttctggtga attttcaaga    840

aatgattcct gcctttggaa ttttcagact gctgatcatc atcctgataa ttgtgttgga    900

catgggattt gctctctata gaaggttctt tgttcctgaa gatgggtctc cggtgtcttt    960

tgcagctcac attgcaggtg gatttgctgg aatgtccatt ggctacacgg tgtttagctg   1020

ctttgataaa gcactgctga aagatccaag gttttggata gcaattgctg catatttagc   1080

ttgtgtctta tttgctgtgt ttttcaacat tttcctatct ccagcaaact gacctgcccc   1140

tattgtaagt caattaataa aaagagccat ctggaggaaa taaaaaaaaa aggaagactc   1200

tatgaagaaa cagagaagtc tcagaaaagg ctaacaattt tatatagagg acaaaacagc   1260

attaaactca tcagttgcaa agattgccta taaaaggacc ttaggattta aggaaggggc   1320

ttcttaatgt agaaagggaa gaagaagaga gaaaagaagg gtagtaaaaa ctagagattg   1380

gggccaggcg cagtggctca cgcctgtaat cccagcactt tgggaggctg aggcgggtga   1440

aatcacctga ggtcatgagt tcaagaccag cctgaccaat atggtgaaac cctgtctcta   1500

ctaaagaaaa tacaaaaatt agccgggcgt ggtggcgtgt gcctgtagtc ccagctactt   1560

gcgaggctga ggcaggagaa ttgcttgaac ctgggaggcg aaggttgcag tgagccgaga   1620

ttgcgccact gcactccagc ctgggtgaca gagcgacact cggtctcaaa aaacaaaaca   1680

aaacaaaaca aaattagaga ttgggtcttt cccaggcata tggtattcta taaaacagac   1740

ttactctcct tggaggatat attttggaga atgcttcata aaatctatga atactgtaca   1800

atgctgataa taaaaacttt ttatacctgt                                    1830


<210>  6202
<211>  303
<212>  PRT
<213>  Homosapiens

<400>  6202

Met Ala Ala Val His Asp Leu Glu Met Glu Ser Met Asn Leu Asn Met 
1               5                   10                  15      


Gly Arg Glu Met Lys Glu Glu Leu Glu Glu Glu Glu Lys Met Arg Glu 
            20                  25                  30          


Asp Gly Gly Gly Lys Asp Arg Ala Lys Ser Lys Lys Val His Arg Ile 
        35                  40                  45              


Val Ser Lys Trp Met Leu Pro Glu Lys Ser Arg Gly Thr Tyr Leu Glu 
    50                  55                  60                  


Arg Ala Asn Cys Phe Pro Pro Pro Val Phe Ile Ile Ser Ile Ser Leu 
65                  70                  75                  80  


Ala Glu Leu Ala Val Phe Ile Tyr Tyr Ala Val Trp Lys Pro Gln Lys 
                85                  90                  95      


Gln Trp Ile Thr Leu Asp Thr Gly Ile Leu Glu Ser Pro Phe Ile Tyr 
            100                 105                 110         


Ser Pro Glu Lys Arg Glu Glu Ala Trp Arg Phe Ile Ser Tyr Met Leu 
        115                 120                 125             


Val His Ala Gly Val Gln His Ile Leu Gly Asn Leu Cys Met Gln Leu 
    130                 135                 140                 


Val Leu Gly Ile Pro Leu Glu Met Val His Lys Gly Leu Arg Val Gly 
145                 150                 155                 160 


Leu Val Tyr Leu Ala Gly Val Ile Ala Gly Ser Leu Ala Ser Ser Ile 
                165                 170                 175     


Phe Asp Pro Leu Arg Tyr Leu Val Gly Ala Ser Gly Gly Val Tyr Ala 
            180                 185                 190         


Leu Met Gly Gly Tyr Phe Met Asn Val Leu Val Asn Phe Gln Glu Met 
        195                 200                 205             


Ile Pro Ala Phe Gly Ile Phe Arg Leu Leu Ile Ile Ile Leu Ile Ile 
    210                 215                 220                 


Val Leu Asp Met Gly Phe Ala Leu Tyr Arg Arg Phe Phe Val Pro Glu 
225                 230                 235                 240 


Asp Gly Ser Pro Val Ser Phe Ala Ala His Ile Ala Gly Gly Phe Ala 
                245                 250                 255     


Gly Met Ser Ile Gly Tyr Thr Val Phe Ser Cys Phe Asp Lys Ala Leu 
            260                 265                 270         


Leu Lys Asp Pro Arg Phe Trp Ile Ala Ile Ala Ala Tyr Leu Ala Cys 
        275                 280                 285             


Val Leu Phe Ala Val Phe Phe Asn Ile Phe Leu Ser Pro Ala Asn 
    290                 295                 300             


<210>  6203
<211>  938
<212>  DNA
<213>  Homosapiens

<400>  6203
accaaaacaa ggctttgcaa accaccttat gcaaagacta aaatattctc tctatactgc     60

ttagttctat tacttggtct attcctttca aggtcttctt tcatttcctt agtgtatgat    120

acaaaacaat acagtaccta ttttgtgcaa gaaaaagtgt ctgtcctcag taattttaca    180

aagagatgag caaacaacta ttataaagta cagaatataa caactactat gacaaaaata    240

aatttattgt agaagcactt aggaaggagt gattttctca gcagaagggt ggagtccttg    300

ctactctgag gaggaggaga tagcattttc attaaacttt gaagaatctt tttttttttt    360

tttgagatgg agtcccactt gcaccccagc ctgggcaaca agagtgagac tctgtctcaa    420

aaaaattgaa aaaaaataaa attagctggc tgtggtggca catgcctata attccaacta    480

ctggggagtc tgaggcacga ggatcacttg aacctgggag gcagaggttg cagggagctg    540

agatcgcacc actgcactcc agcctggtga cagaatgaga ctctgtctca aaaaacaaag    600

aagtagtcca gagcaactta gagcaatgat tctcaaatgc taacctatag actagggctg    660

gggtgattat atcataatca tatgagaaat ttatttttaa aatagataca aatgtctact    720

tctgaccatg ataaggtcac aagaatagga tttgctgtct cacttgaaaa agccaaaagc    780

actggacaac atataggaaa gaatggtctt caagatacta gacatcagaa aacaaaacca    840

gtaaaccctt agagacaggg aatcagttat taatagatga gttatctgat tgcccaggta    900

ctaccttgag ggagattaca gaatacagcg catgaagc                            938


<210>  6204
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  6204

Met Ser Thr Ser Asp His Asp Lys Val Thr Arg Ile Gly Phe Ala Val 
1               5                   10                  15      


Ser Leu Glu Lys Ala Lys Ser Thr Gly Gln His Ile Gly Lys Asn Gly 
            20                  25                  30          


Leu Gln Asp Thr Arg His Gln Lys Thr Lys Pro Val Asn Pro 
        35                  40                  45      


<210>  6205
<211>  697
<212>  DNA
<213>  Homosapiens

<400>  6205
acggaggagc gcctggcaga gcgggatctt cagggcagcg ggcaacccct tggcccagga     60

agcctggaac gcaaggaccg gagggcgtgg gctgggacgc ccctaccttg gtctttcagg    120

gaaaggcctt ggaaagcagt cgttgcgcca gacagcccag ggaagagcgg cagcctgagg    180

acctagggcc acctgctgtt ccctgggatt catgtccttc tggggaggag ggaggaccca    240

ggacaatggc tgctgttcat gatctggaga tggagagcat gaatctgaat atggggagag    300

agatgaaaga agagctggag gaagaggaga aaatgagaga ggatggggga ggtaaagatc    360

gggccaagag taaaaaggtc cacaggattg tctcaaaatg gatgctgccc gaaaagtccc    420

gaggaacata cttggagaga gctaactgct tcccgcctcc cgtgttcatc atctccatca    480

gcctggccga gctggcagtg tttatttact atgctgtgtg gaagcctcag aaacagtgga    540

tcacgttgga cacaggcatc ttggagagtc cctttatcta cagtcctgag aagagggagg    600

aagcctggag gtttatctca tacatgctgg tacatgctgg gtaagcaatg atagttaagc    660

ccctggtatc agaggtgatt atatcattgt aacctct                             697


<210>  6206
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  6206

Met Ala Ala Val His Asp Leu Glu Met Glu Ser Met Asn Leu Asn Met 
1               5                   10                  15      


Gly Arg Glu Met Lys Glu Glu Leu Glu Glu Glu Glu Lys Met Arg Glu 
            20                  25                  30          


Asp Gly Gly Gly Lys Asp Arg Ala Lys Ser Lys Lys Val His Arg Ile 
        35                  40                  45              


Val Ser Lys Trp Met Leu Pro Glu Lys Ser Arg Gly Thr Tyr Leu Glu 
    50                  55                  60                  


Arg Ala Asn Cys Phe Pro Pro Pro Val Phe Ile Ile Ser Ile Ser Leu 
65                  70                  75                  80  


Ala Glu Leu Ala Val Phe Ile Tyr Tyr Ala Val Trp Lys Pro Gln Lys 
                85                  90                  95      


Gln Trp Ile Thr Leu Asp Thr Gly Ile Leu Glu Ser Pro Phe Ile Tyr 
            100                 105                 110         


Ser Pro Glu Lys Arg Glu Glu Ala Trp Arg Phe Ile Ser Tyr Met Leu 
        115                 120                 125             


Val His Ala Gly 
    130         


<210>  6207
<211>  662
<212>  DNA
<213>  Homosapiens

<400>  6207
agagcgggat cttcagggca gcgggcaacc ccttggccca ggaagcctgg aacgcaagga     60

ccggagggcg tgggctggga cgcccctacc ttggtctttc agggaaaggc cttggaaagc    120

agtcgttgcg ccagacagcc cagggaagag cggcagcctg aggacctagg gccacctgct    180

gttccctggg attcatgtcc ttctggggag gagggaggac ccaggacaat ggctgctgtt    240

catgatctgg agatggagag catgaatctg aatatgggga gagagatgaa agaagagctg    300

gaggaagagg agaaaatgag agaggatggg ggaggtaaag atcgggccaa gagtaaaaag    360

gtccacagga ttgtctcaaa atggatgctg cccgaaaagt cccgaggaac atacttggag    420

agagctaact gcttcccgcc tcccgtgttc atcatctcca tcagcctggc cgaggtgaat    480

ggggagcggg gtgggcaccg gggtaagtgg catggggaag ctgggaacaa actaggggtc    540

agatctagat ctagagaaga gactgggaac atgggagaga gcttcgtggg gatggggaca    600

gcacacacct cacctctgcc tctgctctcc ccacagctgc ctttgaggct ttccctatac    660

tc                                                                   662


<210>  6208
<211>  143
<212>  PRT
<213>  Homosapiens

<400>  6208

Met Ala Ala Val His Asp Leu Glu Met Glu Ser Met Asn Leu Asn Met 
1               5                   10                  15      


Gly Arg Glu Met Lys Glu Glu Leu Glu Glu Glu Glu Lys Met Arg Glu 
            20                  25                  30          


Asp Gly Gly Gly Lys Asp Arg Ala Lys Ser Lys Lys Val His Arg Ile 
        35                  40                  45              


Val Ser Lys Trp Met Leu Pro Glu Lys Ser Arg Gly Thr Tyr Leu Glu 
    50                  55                  60                  


Arg Ala Asn Cys Phe Pro Pro Pro Val Phe Ile Ile Ser Ile Ser Leu 
65                  70                  75                  80  


Ala Glu Val Asn Gly Glu Arg Gly Gly His Arg Gly Lys Trp His Gly 
                85                  90                  95      


Glu Ala Gly Asn Lys Leu Gly Val Arg Ser Arg Ser Arg Glu Glu Thr 
            100                 105                 110         


Gly Asn Met Gly Glu Ser Phe Val Gly Met Gly Thr Ala His Thr Ser 
        115                 120                 125             


Pro Leu Pro Leu Leu Ser Pro Gln Leu Pro Leu Arg Leu Ser Leu 
    130                 135                 140             


<210>  6209
<211>  499
<212>  DNA
<213>  Homosapiens

<400>  6209
gtgttaaata gagcttctct cagggaaaga tttcattctg attggtgttc accttcaaac     60

tgcgatgaga tccatgaccg ggtaaaaaat gtcttgaaat cacatcaggc tcatcaaaga    120

catttatatg atgagagaga cctagagaaa gatgatgaac tggaactgaa aagaagtctt    180

ttatgtagag actctgccta tgacagtgac cccgagtata ggaatgcacc atatgtcctc    240

atctgaaagt ctctgcagga tggtctgact cacgcgagtg gttttgagat aagttgtgtt    300

atacctcaag ttaggtaaag tcgagagatg aactaactta aaaagtagtg atgtttacat    360

agaatctaaa ttggaaaaga caataatatc agcattagaa agtttgcctt taagtaaaaa    420

aaattattag ccataatagg ttttacattc ttcgtaatag aatatcctaa agcaataaaa    480

cctccactat gtgaactct                                                 499


<210>  6210
<211>  81
<212>  PRT
<213>  Homosapiens

<400>  6210

Val Leu Asn Arg Ala Ser Leu Arg Glu Arg Phe His Ser Asp Trp Cys 
1               5                   10                  15      


Ser Pro Ser Asn Cys Asp Glu Ile His Asp Arg Val Lys Asn Val Leu 
            20                  25                  30          


Lys Ser His Gln Ala His Gln Arg His Leu Tyr Asp Glu Arg Asp Leu 
        35                  40                  45              


Glu Lys Asp Asp Glu Leu Glu Leu Lys Arg Ser Leu Leu Cys Arg Asp 
    50                  55                  60                  


Ser Ala Tyr Asp Ser Asp Pro Glu Tyr Arg Asn Ala Pro Tyr Val Leu 
65                  70                  75                  80  


Ile 
    


<210>  6211
<211>  4971
<212>  DNA
<213>  Homosapiens

<400>  6211
gcttctccgg cggaacccag gctggaccgc gggccccggc ctgggggcca ctgctgccac     60

cgccgccgcc acctcgtctc ctccccgtcc ccgcccagcc ccaggtctcc ccgcctcact    120

cgggcccgtg gccggggtca ctccccgccg cccctccccg cacggatgcc gaaggtgaag    180

gcgctgcagt gcgccctggc gctggagatc agctcagtaa cttgcccagg agtcgtgctt    240

aaagacaaag aggacatcta tcttagcatc tgtgtgtttg gccaatacaa aaagacacaa    300

tgtgtcccag ccacttttcc cctggtcttc aatgccagaa tggtgtttga aaaggtgttc    360

ccggacgcag tagatcctgg agatgtggtt acacagcttg aatatgatac agcagtgttc    420

gagttgatac agctagttcc accagtgggt gaaacactgt ctacgtatga cgaaaataca    480

cgagatttca tgtttccggg tccaaaccaa atgtctggac accatgattc aaaccgccag    540

gttaccatga ggaggatttc tggccttcga ggaaatgctc caaggctgga attttctacg    600

acttcagtga ttactgaatg tctgataagt tcaaggaaat gccacactca ggataaattt    660

atttaccatt tggctccagt tgaaaaatca catggcagac tgcaaaacag aacatcaaga    720

tcacaaaaga aaaaatccaa gtcacctgag agaagtaaat actgtataaa tgcaaaaaac    780

tacgaacagc ctacaatttc ttcaaaatca cactctccat ctccctacac aaaaagacgc    840

atgtgtgagc tatctgaaga caccaggcgg cggctggccc atttaaatct gggaccctat    900

gagttcaaaa aagaaacaga taaacctcca tttgtgatta gacatgttga tcccccaagt    960

cccagggctg atactttatt gggatcttct ggaagagact gtgaaagaga tggatggtca   1020

agggtgcaca atgatcattc tcatcttggc tgctgccgac ccaaggatta taaggttatc   1080

aggacacccc atgggagaga cttcgatgac tctttagaaa aatgtgaaga gtatttgagc   1140

ccaaggtcgt gtagtaagcc ccggcattca gcgaggacct tgctagtcca ttcagcaccc   1200

tcaacaatgc caaagcattc tccaagccct gtgttaaata gagcttctct cagggaaaga   1260

tttcattctg attggtgttc accttcaaac tgcgatgaga tccatgaccg ggtaaaaaat   1320

gtcttgaaat cacatcaggc tcatcaaaga catttatatg atgagagaga cctagagaaa   1380

gatgatgaac tggaactgaa aagaagtctt ttatgtagag actctgccta tgacagtgac   1440

cccgagtata gctcatgtca gcagccacgt ggcactttcc atttggatga cggtgaatac   1500

tggtccaaca gggcagcctc ttataaggga aaatcccacc gacccatctt tgagaacagc   1560

atggacaaga tgtacaggaa cttatacaaa aaggcctgta gttctgcttc acatacacag   1620

gaaagcttct gagaccatcc atgataaacc tcattagtgt ccgtgtcaat ttctcaatga   1680

aaatgtttga tgtgatcaat atctgtattc ctttttttaa aaaaaatggg attataacta   1740

agtacaatag ttatacttga ataagttcat tacttcaaat ggtaaattat cataggcaag   1800

ccttttaaaa taattattac agaagagtct gctgtgttac aaacattaga gctctgtcac   1860

acaatcacaa cttccaatat gtgacaagga tattctgtta catgtacacc tcatattcca   1920

tctgcaaatc caagaatagt tcctttctag aaatgttttt tttgccttac tcaccttgca   1980

attttcttct catctactta actggttatc ttgcctgtgt aagatttaat taatattgac   2040

taccttttct tggtgatgaa caaaatgata tcctatacag aaatgaattt cctaagggtt   2100

taaaccctgt tttcactaac attttctact ttttcctttt tcagaacagg ctattctatt   2160

tcttagctca taggctttct ttttaaagac tatatgatca ttcactcctt tttctctgga   2220

agaactgtgt aagttgctta aaatgcatag cagttagcta gaaatatcag tgccatggat   2280

gatcaaaaat ttgaataact aatttttaaa gataaaattc tttgcatgat tttttttcta   2340

gggccatacc ttttggtgca accagaatca gaaaatggcc tctgttagta agcttataga   2400

aacctaaaaa taataatgga attatattgt aatttgactg cttggaattt gtgtaagtac   2460

catatggccc aaggcactat tatagtatcc tcactttaaa aaaaaaaaca cttggaacca   2520

caatgtgagt aaaatattat agcagaacgc tttgtggtag acactgaaaa tgttgttgat   2580

tgatggatag aattaacttc tcctccccca ccccagcaca cacctgtgaa gccaatgata   2640

ctataaagac ataaagaaat cagctacttt atatttaata gagagtgagg ggagggaaag   2700

gagagtgtag gaataagtga actgggctta tagtcttgaa gagttgccta aaagataata   2760

ttttctcatt gactctgttt ttgattaatt ttacagttat gattgaaaaa gaacaaaatg   2820

aacttccttt aaaatgaaat taaaatgtga aacttgctga cttatttttg tagtagaact   2880

tgttaacatc atgttaaggg tgctttagta tcacagtctg tgatatatca gaaagggcat   2940

tagagctatc tctatgagcc aggagtccta ggctttagta tcccatgtct gccgttttct   3000

agctgagtct atttaattct cagatccttt gtttcctcag ctatcaaatg ataagaatgt   3060

agtagacccc aaactatgtt ctgtggacca agatcactgt tttaggagat aatcgtagga   3120

atgtaggtat aagtatgtaa ttggccatct aagtttagga aaatctgttt gctacacaca   3180

tacacacaca cacacacaca cacacacaca cacacacacc tcttagagag tcatatgtag   3240

gattatagag gtaaaaagag atgatattaa tgctggaata gcgcctgtaa actggggctg   3300

tctacagcaa attaggatat atggtcactg tgctcattgt gaacagtagc ttgttcgagg   3360

ctttaagaaa attctggtat aaatctgtct tactctgcat ctagtagaca gcctggcatg   3420

taattgatgt tccttaaata tttatcgaat taacccagaa ttttctaaac taaatttagc   3480

atgtaccact atttgttatt cttgccacca ccccccattc ccctagctcc tcacactacc   3540

tgccaatgtc atcctaaggt acatgtggat acctaggttg tagaaatgct ggactacaca   3600

attgctgagt tactctctgg ctgtagatta tatgatgagg tattttacaa tcagcttttg   3660

aaggtcaaca ttgaataatg ctcttttaaa aaaattatat cctcagtgtt tttccatgga   3720

aaaataagtg aaaattcttt taagagttgc tgtttggtga aaagaacaaa catgactttc   3780

aaagaaaatg ttttactatc accaaaatct cccaagtgaa taagtaccac agaaattact   3840

tattgcacct gtatctgcca ttggctgtga aaaaggctgc aaaaagtagg gctgaaaggg   3900

aaactttaga aactaatact ctgaaagatg ttttcctatg gattaaattt agtgtctttc   3960

tgaaagttgg gggcaaattc ccagatacta atagcatctt tgctaagtgt ctgattatct   4020

tctatcccct aggaggaaag agtggtccat gttgctgtaa ctactactat gagtgcttat   4080

gctgtattgt ttttaaagag taaaaccttt aagtactaat agttgtcttt tctcattcac   4140

aggagcagaa aggtgcagtt gtttattctc ttagcctttt ttttttcctg tatttcccac   4200

aaatctagaa ataattattg gagttaatat gaaagataaa taggcttttc tttttacttt   4260

ttaatttttt tctttaaatc ataaaaaacc ttgggattta gaaaaatgtc aaaatcgaca   4320

aataaagatg aatcattgga atgagactct tccttggttc tactagctag ttatataacc   4380

ttatttaagt catttatgct tcttggagct cagttttctc accaacaagg tgataaaagg   4440

gttaatttag aatgatcctt tgacatttca taattgtaca attaatatgt acgatcagga   4500

agtcctaggc aggcagagtt gttttctgat ttccaaagat taagcccctg atgaaaaatc   4560

tggaacaaat agagaatttt cattattgtg ttcatttgct aataatagct ttattgagat   4620

ataattcact ctgaaaaagt atacaattaa gtggttttta ctatattcac agagttgtgc   4680

aacaataacc actcactaat tacagaatat tttataactc ccaaaagaaa tcctgtaacc   4740

attagtgatc acttcccact acctcctccc cacaactcct ggaaaccact atatgctttt   4800

tgtctccatg cctattctgg acatttcata taaatggaac catacaacat gtgacctatt   4860

gtatgtggct tctttcactt agcaaaatat tttgagagtt catgcatgtt gtaacacgta   4920

tgaatacttc attccttttt attactaaat aataatccat catatgaata t            4971


<210>  6212
<211>  488
<212>  PRT
<213>  Homosapiens

<400>  6212

Met Pro Lys Val Lys Ala Leu Gln Cys Ala Leu Ala Leu Glu Ile Ser 
1               5                   10                  15      


Ser Val Thr Cys Pro Gly Val Val Leu Lys Asp Lys Glu Asp Ile Tyr 
            20                  25                  30          


Leu Ser Ile Cys Val Phe Gly Gln Tyr Lys Lys Thr Gln Cys Val Pro 
        35                  40                  45              


Ala Thr Phe Pro Leu Val Phe Asn Ala Arg Met Val Phe Glu Lys Val 
    50                  55                  60                  


Phe Pro Asp Ala Val Asp Pro Gly Asp Val Val Thr Gln Leu Glu Tyr 
65                  70                  75                  80  


Asp Thr Ala Val Phe Glu Leu Ile Gln Leu Val Pro Pro Val Gly Glu 
                85                  90                  95      


Thr Leu Ser Thr Tyr Asp Glu Asn Thr Arg Asp Phe Met Phe Pro Gly 
            100                 105                 110         


Pro Asn Gln Met Ser Gly His His Asp Ser Asn Arg Gln Val Thr Met 
        115                 120                 125             


Arg Arg Ile Ser Gly Leu Arg Gly Asn Ala Pro Arg Leu Glu Phe Ser 
    130                 135                 140                 


Thr Thr Ser Val Ile Thr Glu Cys Leu Ile Ser Ser Arg Lys Cys His 
145                 150                 155                 160 


Thr Gln Asp Lys Phe Ile Tyr His Leu Ala Pro Val Glu Lys Ser His 
                165                 170                 175     


Gly Arg Leu Gln Asn Arg Thr Ser Arg Ser Gln Lys Lys Lys Ser Lys 
            180                 185                 190         


Ser Pro Glu Arg Ser Lys Tyr Cys Ile Asn Ala Lys Asn Tyr Glu Gln 
        195                 200                 205             


Pro Thr Ile Ser Ser Lys Ser His Ser Pro Ser Pro Tyr Thr Lys Arg 
    210                 215                 220                 


Arg Met Cys Glu Leu Ser Glu Asp Thr Arg Arg Arg Leu Ala His Leu 
225                 230                 235                 240 


Asn Leu Gly Pro Tyr Glu Phe Lys Lys Glu Thr Asp Lys Pro Pro Phe 
                245                 250                 255     


Val Ile Arg His Val Asp Pro Pro Ser Pro Arg Ala Asp Thr Leu Leu 
            260                 265                 270         


Gly Ser Ser Gly Arg Asp Cys Glu Arg Asp Gly Trp Ser Arg Val His 
        275                 280                 285             


Asn Asp His Ser His Leu Gly Cys Cys Arg Pro Lys Asp Tyr Lys Val 
    290                 295                 300                 


Ile Arg Thr Pro His Gly Arg Asp Phe Asp Asp Ser Leu Glu Lys Cys 
305                 310                 315                 320 


Glu Glu Tyr Leu Ser Pro Arg Ser Cys Ser Lys Pro Arg His Ser Ala 
                325                 330                 335     


Arg Thr Leu Leu Val His Ser Ala Pro Ser Thr Met Pro Lys His Ser 
            340                 345                 350         


Pro Ser Pro Val Leu Asn Arg Ala Ser Leu Arg Glu Arg Phe His Ser 
        355                 360                 365             


Asp Trp Cys Ser Pro Ser Asn Cys Asp Glu Ile His Asp Arg Val Lys 
    370                 375                 380                 


Asn Val Leu Lys Ser His Gln Ala His Gln Arg His Leu Tyr Asp Glu 
385                 390                 395                 400 


Arg Asp Leu Glu Lys Asp Asp Glu Leu Glu Leu Lys Arg Ser Leu Leu 
                405                 410                 415     


Cys Arg Asp Ser Ala Tyr Asp Ser Asp Pro Glu Tyr Ser Ser Cys Gln 
            420                 425                 430         


Gln Pro Arg Gly Thr Phe His Leu Asp Asp Gly Glu Tyr Trp Ser Asn 
        435                 440                 445             


Arg Ala Ala Ser Tyr Lys Gly Lys Ser His Arg Pro Ile Phe Glu Asn 
    450                 455                 460                 


Ser Met Asp Lys Met Tyr Arg Asn Leu Tyr Lys Lys Ala Cys Ser Ser 
465                 470                 475                 480 


Ala Ser His Thr Gln Glu Ser Phe 
                485             


<210>  6213
<211>  4117
<212>  DNA
<213>  Homosapiens

<400>  6213
gcttctccgg cggaacccag gctggaccgc gggccccggc ctgggggcca ctgctgccac     60

cgccgccgcc acctcgtctc ctccccgtcc ccgcccagcc ccaggtctcc ccgcctcact    120

cgggcccgtg gccggggtca ctccccgccg cccctccccg cacggatgcc gaaggtgaag    180

gcgctgcagt gcgccctggc gctggagatc agctcagtaa cttgcccagg agtcgtgctt    240

aaagacaaag aggacatcta tcttagcatc tgtgtgtttg gccaatacaa aaagacacaa    300

tgtgtcccag ccacttttcc cctggtcttc aatgccagaa tggtgtttga aaaggtgttc    360

ccggacgcag tagatcctgg agatgtggtt acacagcttg aatatgatac agcagtgttc    420

gagttgatac agctagttcc accagtgggt gaaacactgt ctacgtatga cgaaaataca    480

cgagatttca tgtttccggg tccaaaccaa atgtctggac accatgattc aaaccgccag    540

gttaccatga ggaggatttc tggccttcga ggaaatgctc caaggctgga attttctacg    600

acttcagtga ttactgaatg tctgataagt tcaaggaaat gccacactca ggataaattt    660

atttaccatt tggctccagt tgaaaaatca catggcagac tgcaaaacag aacatcaaga    720

tcacaaaaga aaaaatccaa gtcacctgag agaagtaaat actgtataaa tgcaaaaaac    780

tacgaacagc ctacaatttc ttcaaaatca cactctccat ctccctacac aaaaagacgc    840

atgtgtgagc tatctgaaga caccaggcgg cggctggccc atttaaatct gggaccctat    900

gagttcaaaa aagaaacaga taaacctcca tttgtgatta gacatgttga tcccccaagt    960

cccagggctg atactttatt gggatcttct ggaagagact gtgaaagaga tggatggtca   1020

agggtgcaca atgatcattc tcatcttggc tgctgccgac ccaaggatta taaggttatc   1080

aggacacccc atgggagaga cttcgatgac tctttagaaa aatgtgaaga gtatttgagc   1140

ccaaggtcgt gtagtaagcc ccggcattca gcgaggacct tgctagtcca ttcagcaccc   1200

tcaacaatgc caaagcattc tccaagccct gtgttaaata gagcttctct cagggaaaga   1260

tttcattctg attggtgttc accttcaaac tgcgatgaga tccatgaccg ggtaaaaaat   1320

gtcttgaaat cacatcaggc tcatcaaaga catttatatg atgagagaga cctagagaaa   1380

gatgatgaac tggaactgaa aagaagtctt ttatgtagag actctgccta tgacagtgac   1440

cccgagtata gctcatgtca gcagccacgt ggcactttcc atttggatga cggtgaatac   1500

tggtccaaca gggcagcctc ttataaggga aaatcccacc gacccatctt tgagaacagc   1560

atggacaaga tgtacaggaa cttatacaaa aaggcctgta gttctgcttc acatacacag   1620

gaaagcttct gagaccatcc atgataaacc tcattagtgt ccgtgtcaat ttctcaatga   1680

aaatgtttga tgtgatcaat atctgtattc ctttttttaa aaaaaatggg attataacta   1740

agtacaatag ttatacttga ataagttcat tacttcaaat ggtaaattat cataggcaag   1800

ccttttaaaa taattattac agaagagtct gctgtgttac aaacattaga gctctgtcac   1860

acaatcacaa cttccaatat gtgacaagga tattctgtta catgtacacc tcatattcca   1920

tctgcaaatc caagaatagt tcctttctag aaatgttttt tttgccttac tcaccttgca   1980

attttcttct catctactta actggttatc ttgcctgtgt aagatttaat taatattgac   2040

taccttttct tggtgatgaa caaaatgata tcctatacag aaatgaattt cctaagggtt   2100

taaaccctgt tttcactaac attttctact ttttcctttt tcagaacagg ctattctatt   2160

tcttagctca taggctttct ttttaaagac tatatgatca ttcactcctt tttctctgga   2220

agaactgtgt aagttgctta aaatgcatag cagttagcta gaaatatcag tgccatggat   2280

gatcaaaaat ttgaataact aatttttaaa gataaaattc tttgcatgat tttttttcta   2340

gggccatacc ttttggtgca accagaatca gaaaatggcc tctgttagta agcttataga   2400

aacctaaaaa taataatgga attatattgt aatttgactg cttggaattt gtgtaagtac   2460

catatggccc aaggcactat tatagtatcc tcactttaaa aaaaaaaaca cttggaacca   2520

caatgtgagt aaaatattat agcagaacgc tttgtggtag acactgaaaa tgttgttgat   2580

tgatggatag aattaacttc tcctccccca ccccagcaca cacctgtgaa gccaatgata   2640

ctataaagac ataaagaaat cagctacttt atatttaata gagagtgagg ggagggaaag   2700

gagagtgtag gaataagtga actgggctta tagtcttgaa gagttgccta aaagataata   2760

ttttctcatt gactctgttt ttgattaatt ttacagttat gattgaaaaa gaacaaaatg   2820

aacttccttt aaaatgaaat taaaatgtga aacttgctga cttatttttg tagtagaact   2880

tgttaacatc atgttaaggg tgctttagta tcacagtctg tgatatatca gaaagggcat   2940

tagagctatc tctatgagcc aggagtccta ggctttagta tcccatgtct gccgttttct   3000

agctgagtct atttaattct cagatccttt gtttcctcag ctatcaaatg ataagaatgt   3060

agtagacccc aaactatgtt ctgtggacca agatcactgt tttaggagat aatcgtagga   3120

atgtaggtat aagtatgtaa ttggccatct aagtttagga aaatctgttt gctacacaca   3180

tacacacaca cacacacaca cacacacaca cacacacacc tcttagagag tcatatgtag   3240

gattatagag gtaaaaagag atgatattaa tgctggaata gcgcctgtaa actggggctg   3300

tctacagcaa attaggatat atggtcactg tgctcattgt gaacagtagc ttgttcgagg   3360

ctttaagaaa attctggtat aaatctgtct tactctgcat ctagtagaca gcctggcatg   3420

taattgatgt tccttaaata tttatcgaat taacccagaa ttttctaaac taaatttagc   3480

atgtaccact atttgttatt cttgccacca ccccccattc ccctagctcc tcacactacc   3540

tgccaatgtc atcctaaggt acatgtggat acctaggttg tagaaatgct ggactacaca   3600

attgctgagt tactctctgg ctgtagatta tatgatgagg tattttacaa tcagcttttg   3660

aaggtcaaca ttgaataatg ctcttttaaa aaaattatat cctcagtgtt tttccatgga   3720

aaaataagtg aaaattcttt taagagttgc tgtttggtga aaagaacaaa catgactttc   3780

aaagaaaatg ttttactatc accaaaatct cccaagtgaa taagtaccac agaaattact   3840

tattgcacct gtatctgcca ttggctgtga aaaaggctgc aaaaagtagg gctgaaaggg   3900

aaactttaga aactaatact ctgaaagatg ttttcctatg gattaaattt agtgtctttc   3960

tgaaagttgg gggcaaattc ccagatacta atagcatctt tgctaagtgt ctgattatct   4020

tctatcccct aggaggaaag agtggtccat gttgctgtaa ctactactat gagtgcttat   4080

gctgtattgt ttttaaagag taaaaccttt aagtact                            4117


<210>  6214
<211>  488
<212>  PRT
<213>  Homosapiens

<400>  6214

Met Pro Lys Val Lys Ala Leu Gln Cys Ala Leu Ala Leu Glu Ile Ser 
1               5                   10                  15      


Ser Val Thr Cys Pro Gly Val Val Leu Lys Asp Lys Glu Asp Ile Tyr 
            20                  25                  30          


Leu Ser Ile Cys Val Phe Gly Gln Tyr Lys Lys Thr Gln Cys Val Pro 
        35                  40                  45              


Ala Thr Phe Pro Leu Val Phe Asn Ala Arg Met Val Phe Glu Lys Val 
    50                  55                  60                  


Phe Pro Asp Ala Val Asp Pro Gly Asp Val Val Thr Gln Leu Glu Tyr 
65                  70                  75                  80  


Asp Thr Ala Val Phe Glu Leu Ile Gln Leu Val Pro Pro Val Gly Glu 
                85                  90                  95      


Thr Leu Ser Thr Tyr Asp Glu Asn Thr Arg Asp Phe Met Phe Pro Gly 
            100                 105                 110         


Pro Asn Gln Met Ser Gly His His Asp Ser Asn Arg Gln Val Thr Met 
        115                 120                 125             


Arg Arg Ile Ser Gly Leu Arg Gly Asn Ala Pro Arg Leu Glu Phe Ser 
    130                 135                 140                 


Thr Thr Ser Val Ile Thr Glu Cys Leu Ile Ser Ser Arg Lys Cys His 
145                 150                 155                 160 


Thr Gln Asp Lys Phe Ile Tyr His Leu Ala Pro Val Glu Lys Ser His 
                165                 170                 175     


Gly Arg Leu Gln Asn Arg Thr Ser Arg Ser Gln Lys Lys Lys Ser Lys 
            180                 185                 190         


Ser Pro Glu Arg Ser Lys Tyr Cys Ile Asn Ala Lys Asn Tyr Glu Gln 
        195                 200                 205             


Pro Thr Ile Ser Ser Lys Ser His Ser Pro Ser Pro Tyr Thr Lys Arg 
    210                 215                 220                 


Arg Met Cys Glu Leu Ser Glu Asp Thr Arg Arg Arg Leu Ala His Leu 
225                 230                 235                 240 


Asn Leu Gly Pro Tyr Glu Phe Lys Lys Glu Thr Asp Lys Pro Pro Phe 
                245                 250                 255     


Val Ile Arg His Val Asp Pro Pro Ser Pro Arg Ala Asp Thr Leu Leu 
            260                 265                 270         


Gly Ser Ser Gly Arg Asp Cys Glu Arg Asp Gly Trp Ser Arg Val His 
        275                 280                 285             


Asn Asp His Ser His Leu Gly Cys Cys Arg Pro Lys Asp Tyr Lys Val 
    290                 295                 300                 


Ile Arg Thr Pro His Gly Arg Asp Phe Asp Asp Ser Leu Glu Lys Cys 
305                 310                 315                 320 


Glu Glu Tyr Leu Ser Pro Arg Ser Cys Ser Lys Pro Arg His Ser Ala 
                325                 330                 335     


Arg Thr Leu Leu Val His Ser Ala Pro Ser Thr Met Pro Lys His Ser 
            340                 345                 350         


Pro Ser Pro Val Leu Asn Arg Ala Ser Leu Arg Glu Arg Phe His Ser 
        355                 360                 365             


Asp Trp Cys Ser Pro Ser Asn Cys Asp Glu Ile His Asp Arg Val Lys 
    370                 375                 380                 


Asn Val Leu Lys Ser His Gln Ala His Gln Arg His Leu Tyr Asp Glu 
385                 390                 395                 400 


Arg Asp Leu Glu Lys Asp Asp Glu Leu Glu Leu Lys Arg Ser Leu Leu 
                405                 410                 415     


Cys Arg Asp Ser Ala Tyr Asp Ser Asp Pro Glu Tyr Ser Ser Cys Gln 
            420                 425                 430         


Gln Pro Arg Gly Thr Phe His Leu Asp Asp Gly Glu Tyr Trp Ser Asn 
        435                 440                 445             


Arg Ala Ala Ser Tyr Lys Gly Lys Ser His Arg Pro Ile Phe Glu Asn 
    450                 455                 460                 


Ser Met Asp Lys Met Tyr Arg Asn Leu Tyr Lys Lys Ala Cys Ser Ser 
465                 470                 475                 480 


Ala Ser His Thr Gln Glu Ser Phe 
                485             


<210>  6215
<211>  2283
<212>  DNA
<213>  Homosapiens

<400>  6215
ggatgccgaa ggtgaaggcg ctgcagtgcg ccctggcgct ggagatcagc tcagtaactt     60

gcccaggagt cgtgcttaaa gacaaagagg acatctatct tagcatctgt gtgtttggcc    120

aatacaaaaa gacacaatgt gtcccagcca cttttcccct ggtcttcaat gccagaatgg    180

tgtttgaaaa ggtgttcccg gacgcagtag atcctggaga tgtggttaca cagcttgaat    240

atgatacagc agtgttcgag ttgatacagc tagttccacc agtgggtgaa acactgtcta    300

cgtatgacga aaatacacga gatttcatgt ttccgggtcc aaaccaaatg tctggacacc    360

atgattcaaa ccgccaggtt accatgagga ggatttctgg ccttcgagga aatgctccaa    420

ggctggaatt ttctacgact tcagtgatta ctgaatgtct gataagttca aggaaatgcc    480

acactcagga taaatttatt taccatttgg ctccagttga aaaatcacat ggcagactgc    540

aaaacagaac atcaagatca caaaagaaaa aatccaagtc acctgagaga agtaaatact    600

gtataaatgc aaaaaactac gaacagccta caatttcttc aaaatcacac tctccatctc    660

cctacacaaa aagacgcatg tgtgagctat ctgaagacac caggcggcgg ctggcccatt    720

taaatctggg accctatgag ttcaaaaaag aaacagataa acctccattt gtgattagac    780

atgttgatcc cccaagtccc agggctgata ctttattggg atcttctgga agagactgtg    840

aaagagatgg atggtcaagg gtgcacaatg atcattctca tcttggctgc tgccgaccca    900

aggattataa ggttatcagg acaccccatg ggagagactt cgatgactct ttagaaaaat    960

gtgaagagta tttgagccca aggtcgtgta gtaagccccg gcattcagcg aggaccttgc   1020

tagtccattc agcaccctca acaatgccaa agcattctcc aagccctgtg ttaaatagag   1080

cttctctcag ggaaagattt cattctgatt ggtgttcacc ttcaaactgc gatgagatcc   1140

atgaccggga tgagagagac ctagagaaag atgatgaact ggaactgaaa agaagtcttt   1200

tatgtagaga ctctgcctat gacagtgacc ccgagtatag ctcatgtcag cagccacgtg   1260

gcactttcca tttggatgac ggtgaatact ggtccaacag ggcagcctct tataagggaa   1320

aatcccaccg acccatcttt gagaacagca tggacaagat gtacaggaac ttatacaaaa   1380

aggcctgtag ttctgcttca catacacagg aaagcttctg agaccatcca tgataaacct   1440

cattagtgtc cgtgtcaatt tctcaatgaa aatgtttgat gtgatcaata tctgtattcc   1500

tttttttaaa aaaaatggga ttataactaa gtacaatagt tatacttgaa taagttcatt   1560

acttcaaatg gtaaattatc ataggcaagc cttttaaaat aattattaca gaagagtctg   1620

ctgtgttaca aacattagag ctctgtcaca caatcacaac ttccaatatg tgacaaggat   1680

attctgttac atgtacacct catattccat ctgcaaatcc aagaatagtt cctttctaga   1740

aatgtttttt ttgccttact caccttgcaa ttttcttctc atctacttaa ctggttatct   1800

tgcctgtgta agatttaatt aatattgact accttttctt ggtgatgaac aaaatgatat   1860

cctatacaga aatgaatttc ctaagggttt aaaccctgtt ttcactaaca ttttctactt   1920

tttccttttt cagaacaggc tattctattt cttagctcat aggctttctt tttaaagact   1980

atatgatcat tcactccttt ttctctggaa gaactgtgta agttgcttaa aatgcatagc   2040

agttagctag aaatatcagt gccatggatg atcaaaaatt tgaataacta atttttaaag   2100

ataaaattct ttgcatgatt ttttttctag ggccatacct tttggtgcaa ccagaatcag   2160

aaaatggcct ctgttagtaa gcttatagaa acctaaaaat aataatggaa ttatattgta   2220

atttgactgc ttggaatttg tgtaagtacc atatggccca aggcactatt atagtatcct   2280

cac                                                                 2283


<210>  6216
<211>  472
<212>  PRT
<213>  Homosapiens

<400>  6216

Met Pro Lys Val Lys Ala Leu Gln Cys Ala Leu Ala Leu Glu Ile Ser 
1               5                   10                  15      


Ser Val Thr Cys Pro Gly Val Val Leu Lys Asp Lys Glu Asp Ile Tyr 
            20                  25                  30          


Leu Ser Ile Cys Val Phe Gly Gln Tyr Lys Lys Thr Gln Cys Val Pro 
        35                  40                  45              


Ala Thr Phe Pro Leu Val Phe Asn Ala Arg Met Val Phe Glu Lys Val 
    50                  55                  60                  


Phe Pro Asp Ala Val Asp Pro Gly Asp Val Val Thr Gln Leu Glu Tyr 
65                  70                  75                  80  


Asp Thr Ala Val Phe Glu Leu Ile Gln Leu Val Pro Pro Val Gly Glu 
                85                  90                  95      


Thr Leu Ser Thr Tyr Asp Glu Asn Thr Arg Asp Phe Met Phe Pro Gly 
            100                 105                 110         


Pro Asn Gln Met Ser Gly His His Asp Ser Asn Arg Gln Val Thr Met 
        115                 120                 125             


Arg Arg Ile Ser Gly Leu Arg Gly Asn Ala Pro Arg Leu Glu Phe Ser 
    130                 135                 140                 


Thr Thr Ser Val Ile Thr Glu Cys Leu Ile Ser Ser Arg Lys Cys His 
145                 150                 155                 160 


Thr Gln Asp Lys Phe Ile Tyr His Leu Ala Pro Val Glu Lys Ser His 
                165                 170                 175     


Gly Arg Leu Gln Asn Arg Thr Ser Arg Ser Gln Lys Lys Lys Ser Lys 
            180                 185                 190         


Ser Pro Glu Arg Ser Lys Tyr Cys Ile Asn Ala Lys Asn Tyr Glu Gln 
        195                 200                 205             


Pro Thr Ile Ser Ser Lys Ser His Ser Pro Ser Pro Tyr Thr Lys Arg 
    210                 215                 220                 


Arg Met Cys Glu Leu Ser Glu Asp Thr Arg Arg Arg Leu Ala His Leu 
225                 230                 235                 240 


Asn Leu Gly Pro Tyr Glu Phe Lys Lys Glu Thr Asp Lys Pro Pro Phe 
                245                 250                 255     


Val Ile Arg His Val Asp Pro Pro Ser Pro Arg Ala Asp Thr Leu Leu 
            260                 265                 270         


Gly Ser Ser Gly Arg Asp Cys Glu Arg Asp Gly Trp Ser Arg Val His 
        275                 280                 285             


Asn Asp His Ser His Leu Gly Cys Cys Arg Pro Lys Asp Tyr Lys Val 
    290                 295                 300                 


Ile Arg Thr Pro His Gly Arg Asp Phe Asp Asp Ser Leu Glu Lys Cys 
305                 310                 315                 320 


Glu Glu Tyr Leu Ser Pro Arg Ser Cys Ser Lys Pro Arg His Ser Ala 
                325                 330                 335     


Arg Thr Leu Leu Val His Ser Ala Pro Ser Thr Met Pro Lys His Ser 
            340                 345                 350         


Pro Ser Pro Val Leu Asn Arg Ala Ser Leu Arg Glu Arg Phe His Ser 
        355                 360                 365             


Asp Trp Cys Ser Pro Ser Asn Cys Asp Glu Ile His Asp Arg Asp Glu 
    370                 375                 380                 


Arg Asp Leu Glu Lys Asp Asp Glu Leu Glu Leu Lys Arg Ser Leu Leu 
385                 390                 395                 400 


Cys Arg Asp Ser Ala Tyr Asp Ser Asp Pro Glu Tyr Ser Ser Cys Gln 
                405                 410                 415     


Gln Pro Arg Gly Thr Phe His Leu Asp Asp Gly Glu Tyr Trp Ser Asn 
            420                 425                 430         


Arg Ala Ala Ser Tyr Lys Gly Lys Ser His Arg Pro Ile Phe Glu Asn 
        435                 440                 445             


Ser Met Asp Lys Met Tyr Arg Asn Leu Tyr Lys Lys Ala Cys Ser Ser 
    450                 455                 460                 


Ala Ser His Thr Gln Glu Ser Phe 
465                 470         


<210>  6217
<211>  2314
<212>  DNA
<213>  Homosapiens

<400>  6217
taacttgccc aggagtcgtg cttaaagaca aagaggacat ctatcttagc atctgtgtgt     60

ttggccaata caaaaagaca caatgtgtcc cagccacttt tcccctggtc ttcaatgcca    120

gaatggtgtt tgaaaattct tgtagtgggt gaaacactgt ctacgtatga cgaaaataca    180

cgagatttca tgtttccggg tccaaaccaa atgtctggac accatgattc aaaccgccag    240

gttaccatga ggaggatttc tggccttcga ggaaatgctc caaggctgga attttctacg    300

acttcagtga ttactgaatg tctgataagt tcaaggaaat gccacactca ggataaattt    360

atttaccatt tggctccagt tgaaaaatca catggcagac tgcaaaacag aacatcaaga    420

tcacaaaaga aaaaatccaa gtcacctgag agaagtaaat actgtataaa tgcaaaaaac    480

tacgaacagc ctacaatttc ttcaaaatca cactctccat ctccctacac aaaaagacgc    540

atgtgtgagc tatctgaaga caccaggcgg cggctggccc atttaaatct gggaccctat    600

gagttcaaaa aagaaacaga taaacctcca tttgtgatta gacatgtatg tgttctctta    660

agcatttcta tttgaaactg atcagctttt ttcccaaaaa aactgttatt ctgaaatatc    720

tttcaacttc tagcttatat taataatact tttctcttct gactgctacc ctagcagtct    780

aagatgggaa attaatttag aatgaaagaa cttgcttttt ttcagtcttc agacctgaca    840

gagatcaagc tgtgttatga atgccatgtt aaatcctctc agtaccggtt tcctttctta    900

tacaatagat agcataataa cgctaccaat tgaacttggt tgtaattgac attagtacta    960

aaatggcaga gtagggcttt aaaagagaac caaatattct ttatgaaaag gaagaccctc   1020

cttttttaaa ttataaaaat taaaatggaa agtaagtttc cttttaaatt acatcccttg   1080

ggtaaacttt gtatgatgga tcttcaaagc aaattattgt ttgatggtta tgggaaggcc   1140

tttgaaaatg aaaaaagttc atttaagggt aacctagttc tagtctctgt actgaactgt   1200

gcttttgata tagttgaaat ttagagtctt gtgtttatat gattatcaag tagactttgg   1260

ctaaatttaa gggtttataa tcagaatgtt taggaaagga ctccctcaga atcttcatag   1320

tttcctgaat ttctatgaag tatttttacc ttaaaagcaa ttctttactg aaagctttca   1380

gactaataaa aatatggatt aatgttatat gtacatatat aataatacta aacctcaaga   1440

tttaagtgct gatagaagca aaataacttt ttgggatatc tataaaaata tttctgacta   1500

atgtctttaa ttcatttttt ctaaattgta aaatgaattc atccaacatg taaatatgcc   1560

cctttggtgg tctaataact ttttgaacat acacaatctg aaagttcaga ttttctttat   1620

gatacctttt taaaacaatt taaatattgt cttaagcaac atttcattcc acctgtattt   1680

tgactatgag tcgttttttt taactcttaa gtaacagatt gttttatcat aaaagaaaat   1740

ttatagtata atggatactt ttaagtggca acattttatt gaagttattg tgactacttt   1800

tctcatttct acagaatttg attttaactt ttggtcactt ttttgttgtt gtttgaccaa   1860

tattcagata atattttagt tgcatatttg gtgacagttt tagaatgcct ttaattttaa   1920

gtcttcccac aattacaaat taaattgaaa agaaaggata tactatattt tcatctgaag   1980

gaatagtaac attttaatta aaatgctatg tacaaaaata aactgaaata ttttaggggt   2040

aagccacatt aaaattcttt ggaaaaataa ctgcttttct ttaaatgttt gttttattat   2100

tactttttat gtcagtgttt agaatggaat aattctaata ttgcttgata caaactttga   2160

agtttgtatt taaatggttt ccctccctag cttttcaata aacagaaatg cctactccta   2220

agtctatact tagattgctt acattattaa ataggaaagt ggattttccg attgtgtttg   2280

taaacataga gatttttttt cctccatagc catt                               2314


<210>  6218
<211>  186
<212>  PRT
<213>  Homosapiens

<400>  6218

Met Pro Glu Trp Cys Leu Lys Ile Leu Val Val Gly Glu Thr Leu Ser 
1               5                   10                  15      


Thr Tyr Asp Glu Asn Thr Arg Asp Phe Met Phe Pro Gly Pro Asn Gln 
            20                  25                  30          


Met Ser Gly His His Asp Ser Asn Arg Gln Val Thr Met Arg Arg Ile 
        35                  40                  45              


Ser Gly Leu Arg Gly Asn Ala Pro Arg Leu Glu Phe Ser Thr Thr Ser 
    50                  55                  60                  


Val Ile Thr Glu Cys Leu Ile Ser Ser Arg Lys Cys His Thr Gln Asp 
65                  70                  75                  80  


Lys Phe Ile Tyr His Leu Ala Pro Val Glu Lys Ser His Gly Arg Leu 
                85                  90                  95      


Gln Asn Arg Thr Ser Arg Ser Gln Lys Lys Lys Ser Lys Ser Pro Glu 
            100                 105                 110         


Arg Ser Lys Tyr Cys Ile Asn Ala Lys Asn Tyr Glu Gln Pro Thr Ile 
        115                 120                 125             


Ser Ser Lys Ser His Ser Pro Ser Pro Tyr Thr Lys Arg Arg Met Cys 
    130                 135                 140                 


Glu Leu Ser Glu Asp Thr Arg Arg Arg Leu Ala His Leu Asn Leu Gly 
145                 150                 155                 160 


Pro Tyr Glu Phe Lys Lys Glu Thr Asp Lys Pro Pro Phe Val Ile Arg 
                165                 170                 175     


His Val Cys Val Leu Leu Ser Ile Ser Ile 
            180                 185     


<210>  6219
<211>  1240
<212>  DNA
<213>  Homosapiens

<400>  6219
agagttccaa gcccacggcc ccggtcgcgg cctcgccgcc ctcccgcgcc ccgcaccggg     60

agcgggccta gagcactcgc ctcgcccctc cgcgagcagg gctctggcgc ccgcccctgt    120

ccgcaccgct ggcagcctga agagagtcgc tggccatggt cgctgctagg taggatatat    180

ctgcatcttg aaaggaagat aaaacaaaag ccttctttgg aatagatgga tttttgtcac    240

tttctgtgtg aactaaagtg attcaatgtc tcttttggat tgcttctgca cttcaagaac    300

acaagatgaa tcactcagac ctgaaaaaca gtctgaaacc agtatccatc aatacttggt    360

tgatgagcca accctttcct ggtcacctcc atccactaga gccagtgaag tactatgttc    420

caccaacgtt tctcactacg agctccaagt agaaacagga agaggatttg acaacttgac    480

ttctgtccat cttgcatggc atactcccac gggaacactg gtaactataa aaattacaaa    540

tctggaaaac tgcaatgaag aacgcctgaa agctttacag aaagccgtga ttctatccca    600

ctttttccgg catcccaata ttacaactta ctggacagtt ttcactgttg gcagctggct    660

ttgggttatt tctccattta tggcctatgg ttcagcaagt caactcttga ggacctgttt    720

tcctgaagga atgagtgaaa ctttaataag aaacattatc tttggagctg tgagagggtt    780

gaactatctg taccaaaatg gctgtattca caggagtatt aaagccagcc atatcctcat    840

ttctggtgat ggcctagtga ccctctctgg cctgtcccat ctgcatagtt tggttaagca    900

tggacagagg catagggctg tgtatgattt cccacagttc agcacatcag tgcagccgtg    960

gctgagtcca gaactactga gacaggattt acatgggtat aatgtgaagt cagatattta   1020

cagtgttggg attacagcat gtgaattagc cagtgggcag gtgcctttcc aggacatgca   1080

tagaactcag atcttggtac agctctgttt gcaacaagat cctgagaaaa ggccatcagc   1140

aagcagttta ttgtcccatg ttttcttcaa acagatgaaa gaagaaagcc aggattcaat   1200

actttcacgg ttgcctcctg cttataacaa gccatcaata                         1240


<210>  6220
<211>  324
<212>  PRT
<213>  Homosapiens

<400>  6220

Met Ser Leu Leu Asp Cys Phe Cys Thr Ser Arg Thr Gln Asp Glu Ser 
1               5                   10                  15      


Leu Arg Pro Glu Lys Gln Ser Glu Thr Ser Ile His Gln Tyr Leu Val 
            20                  25                  30          


Asp Glu Pro Thr Leu Ser Trp Ser Pro Pro Ser Thr Arg Ala Ser Glu 
        35                  40                  45              


Val Leu Cys Ser Thr Asn Val Ser His Tyr Glu Leu Gln Val Glu Thr 
    50                  55                  60                  


Gly Arg Gly Phe Asp Asn Leu Thr Ser Val His Leu Ala Trp His Thr 
65                  70                  75                  80  


Pro Thr Gly Thr Leu Val Thr Ile Lys Ile Thr Asn Leu Glu Asn Cys 
                85                  90                  95      


Asn Glu Glu Arg Leu Lys Ala Leu Gln Lys Ala Val Ile Leu Ser His 
            100                 105                 110         


Phe Phe Arg His Pro Asn Ile Thr Thr Tyr Trp Thr Val Phe Thr Val 
        115                 120                 125             


Gly Ser Trp Leu Trp Val Ile Ser Pro Phe Met Ala Tyr Gly Ser Ala 
    130                 135                 140                 


Ser Gln Leu Leu Arg Thr Cys Phe Pro Glu Gly Met Ser Glu Thr Leu 
145                 150                 155                 160 


Ile Arg Asn Ile Ile Phe Gly Ala Val Arg Gly Leu Asn Tyr Leu Tyr 
                165                 170                 175     


Gln Asn Gly Cys Ile His Arg Ser Ile Lys Ala Ser His Ile Leu Ile 
            180                 185                 190         


Ser Gly Asp Gly Leu Val Thr Leu Ser Gly Leu Ser His Leu His Ser 
        195                 200                 205             


Leu Val Lys His Gly Gln Arg His Arg Ala Val Tyr Asp Phe Pro Gln 
    210                 215                 220                 


Phe Ser Thr Ser Val Gln Pro Trp Leu Ser Pro Glu Leu Leu Arg Gln 
225                 230                 235                 240 


Asp Leu His Gly Tyr Asn Val Lys Ser Asp Ile Tyr Ser Val Gly Ile 
                245                 250                 255     


Thr Ala Cys Glu Leu Ala Ser Gly Gln Val Pro Phe Gln Asp Met His 
            260                 265                 270         


Arg Thr Gln Ile Leu Val Gln Leu Cys Leu Gln Gln Asp Pro Glu Lys 
        275                 280                 285             


Arg Pro Ser Ala Ser Ser Leu Leu Ser His Val Phe Phe Lys Gln Met 
    290                 295                 300                 


Lys Glu Glu Ser Gln Asp Ser Ile Leu Ser Arg Leu Pro Pro Ala Tyr 
305                 310                 315                 320 


Asn Lys Pro Ser 
                


<210>  6221
<211>  1719
<212>  DNA
<213>  Homosapiens

<400>  6221
agagttccaa gcccacggcc ccggtcgcgg cctcgccgcc ctcccgcgcc ccgcaccggg     60

agcgggccta gagcactcgc ctcgcccctc cgcgagcagg gctctggcgc ccgcccctgt    120

ccgcaccgct ggcagcctga agagagtcgc tggccatggt cgctgctagg taggatatat    180

ctgcatcttg aaaggaagat aaaacaaaag ccttctttgg aatagatgga tttttgtcac    240

tttctgtgtg aactaaagtg attcaatgtc tcttttggat tgcttctgca cttcaagaac    300

acaagatgaa tcactcagac ctgaaaaaca gtctgaaacc agtatccatc aatacttggt    360

tgatgagcca accctttcct ggtcacctcc atccactaga gccagtgaag tactatgttc    420

caccaacgtt tctcactacg agctccaagt agaaacagga agaggatttg acaacttgac    480

ttctgtccat cttgcatggc atactcccac gggaacactg gtaactataa aaattacaaa    540

tctggaaaac tgcaatgaag aacgcctgaa agctttacta tggttcagca agtcaactct    600

tgaggacctg ttttcctgaa ggaatgagtg aaactttaat aagaaacatt atctttggag    660

ctgtgagagg gttgaactat ctgtaccaaa atggctgtat tcacaggagt attaaagcca    720

gccatatcct catttctggt gatggcctag tgaccctctc tggcctgtcc catctgcata    780

gtttggttaa gcatggacag aggcataggg ctgtgtatga tttcccacag ttcagcacat    840

cagtgcagcc gtggctgagt ccagaactac tgagacagga tttacatggg tataatgtga    900

agtcagatat ttacagtgtt gggattacag catgtgaatt agccagtggg caggtgcctt    960

tccaggacat gcatagaact cagatgctgt tacagaaact gaaaggtcct ccttatagcc   1020

cattggatat cagtattttc cctcaatcag aatccagaat gaaaaattcc cggtcaggtg   1080

tagactctgg aattggagaa agtgtgcttg tctccagtgg aactcacaca gtaaatagtg   1140

accgattaca cacaccatcc tcaaaaactt tctctcctgc cttctttagc ttggtacagc   1200

tctgtttgca acaagatcct gagaaaaggc catcagcaag cagtttattg tcccatgttt   1260

tcttcaaaca gatgaaagaa gaaagccagg attcaatact ttcacggttg cctcctgctt   1320

ataacaagcc atcaatacca ttgcctccag tgttaccttg gactgagcca gaatgtgatt   1380

ttcctgatga aaaagactca tacttggaat tctagggctg ccaaatcatt tcatgtccta   1440

tatacttgac actttctcct tgctgctttt tcttctgtat ttctaggtac aaatacgaga   1500

attatacttg aaaatacagt tggtgcactg gagaatctat tatttaaaac cactctgttc   1560

aaaggggcac cagtttgtag tccctctgtt ttgcacagag tactatgaca aggaaacatc   1620

agaattacca atctagctag tgtcatttat tctggaattt ttttctaagc tgtgactaac   1680

tctttttatc tctcaatata atttttgagc cagttaatt                          1719


<210>  6222
<211>  117
<212>  PRT
<213>  Homosapiens

<400>  6222

Met Ser Leu Leu Asp Cys Phe Cys Thr Ser Arg Thr Gln Asp Glu Ser 
1               5                   10                  15      


Leu Arg Pro Glu Lys Gln Ser Glu Thr Ser Ile His Gln Tyr Leu Val 
            20                  25                  30          


Asp Glu Pro Thr Leu Ser Trp Ser Pro Pro Ser Thr Arg Ala Ser Glu 
        35                  40                  45              


Val Leu Cys Ser Thr Asn Val Ser His Tyr Glu Leu Gln Val Glu Thr 
    50                  55                  60                  


Gly Arg Gly Phe Asp Asn Leu Thr Ser Val His Leu Ala Trp His Thr 
65                  70                  75                  80  


Pro Thr Gly Thr Leu Val Thr Ile Lys Ile Thr Asn Leu Glu Asn Cys 
                85                  90                  95      


Asn Glu Glu Arg Leu Lys Ala Leu Leu Trp Phe Ser Lys Ser Thr Leu 
            100                 105                 110         


Glu Asp Leu Phe Ser 
        115         


<210>  6223
<211>  2947
<212>  DNA
<213>  Homosapiens

<400>  6223
aggcaaccgt cgtgccgcgt cttcctgagg tagctcctgt cagcccactg atcccaccac     60

ccgctcccta ctgccccgcg gtcttcgcgt gagctcggag actgagggac aacaaaaatg    120

gcggagggga gccagtcggc gcctgaggca ggcaatgata tgggaaatga tgatgccatt    180

ggagggaatg tgagcaaata tatagtgctt ccaactggct attgtggaca gcccaagaaa    240

ggacatctta tctttgatgc ttgctttgaa agtggtaacc tgggccgggt ggaccaggtc    300

tctgagtttg agtatgatct gttcattagg ccggacacct gtaatccacg cttccgagtc    360

tggttcaact ttactgttga aaatgtgaaa gaatcacaga gggtcatttt caacattgtt    420

aacttcagta aaaccaagag tctctataga gatgggatgg cccctatggt gaaatctacc    480

agcagaccaa aatggcaaag gctgccaccc aaaaatgttt actactaccg ctgcccggac    540

cataggaaga actatgtgat gtcctttgcc ttttgttttg accgagaaga agatatttac    600

cagtttgctt actgctaccc atatacatac actcgcttcc aacattacct tgacagcctg    660

caaaagagaa acatggatta cttctttcgg gagcagctgg gccagagtgt gcaacaacga    720

aagcttgacc tcctgacgat aaccagccct gacaatctcc gggaaggggc agagcagaag    780

gtggtattca tcacaggacg agtccaccca ggggaaacac cctcatcatt tgtgtgccaa    840

gggatcattg acttccttgt aagccagcac cctattgcct gtgtcctccg ggaatacctg    900

gtcttcaaga tcgcaccaat gctcaatcct gatggagtct acctgggcaa ttacaggtgt    960

tctctgatgg gatttgatct gaatcgtcac tggctggatc cctctccatg ggtccatcct   1020

accctgcatg gagtgaaaca actcatcgtc cagatgtaca acgacccaaa aacaagcctg   1080

gagttttata ttgacatcca tgcccactcc accatgatga atggcttcat gtatggcaac   1140

atctttgagg atgaggaacg gttccagagg caggccattt ttcccaagct cctctgccag   1200

aatgctgagg acttctccta ttccagcaca tcctttaacc gggacgctgt gaaagcagga   1260

actggccgtc gcttcctcgg tggactcctg gaccacactt cctattgcta caccctagag   1320

gtctccttct acagctacat catcagtggc accacggctg ctgtgcccta cactgaagaa   1380

gcctatatga agctggggcg gaatgtggca agaacctttt tggactatta tcggctgaac   1440

cccgtggttg aaaaggtggc aattcccatg ccgagactgc gaaataaaga aatagaagtc   1500

cagagaagga aagaaaaatc ccctccttac aagcacccac tcctgcgggg cccagccagc   1560

aactacccca acagcaaagg ggacaagaag agctcagtga accacaaaga cccttcaacc   1620

cctttttaaa gacacggagt cctgggaggt cttatgggga caggagcatg cattttctgc   1680

tggggaatga aattaatcac tcttctctag cttccaagga tttgtggatt aatgcatagg   1740

ctagtgaaag ggaagggata caatgagaaa cttcatcact gattttccct ttttccaatg   1800

gaaaatcaat tgtaagcctt cagctcaaaa agctcaggaa caaaatagga gatcggaacc   1860

aggtgagcac agatgctatt ttctacaaca tagagatctt ccaagatgag gaaaacctac   1920

acatcccttt taagagattt gacacatatc aggtcagttc tttcaaagcc actttacatt   1980

tttaagtttt atagttactg cagatggtta ccttttaaat aggcttggtt gtttacagct   2040

ttagaaatgc agtgtttgta ttttctgatc caaaacaaca gcaacaacac atgcaaccaa   2100

agggcaaatg catcctaggg aacaatggga cagaattttt gaaatcaacg gtggacttaa   2160

atatatggtc actgtatcta agctgcatgc ttgctgattc cctcaaaccc cagcatgcag   2220

atttagaaaa ctgttttgag agctgtttcc caatttcctc ggtagtttaa ttaaaatttt   2280

agctctaaag acaaaaagca ctggtcactc attttaaaag gtttattatg gttaaggtct   2340

ccagatccca ggtgacaggg attaagcctg gcccctgaag atgtaggcat tgctaatctg   2400

caatgaggaa agggtgattg ccaggcaagg aagatgcaaa agacagaagg atgcaccctg   2460

aggcagggag gaatgataaa ataaaacagt agtagcaatt cccaaggtgt ggcaagctaa   2520

atattggcat ttttgtgaag agtaaagtgc ctttgtatga tgaatgggtc caggggggtc   2580

tgctcccttc ctgtctgtgg aaacagcagg ctgagtcacc atgacagcct gctaattaaa   2640

atgacctccc ggaaatgagg attagaacac agggagagga agggaggctc cagggaggaa   2700

aatcccttag cacagagctc cactaaagca ttttttgttt gtttgtttgt ttgtttgttt   2760

gtttgagttg gagattattg aagtttgcta caaaaatcaa aaagaaaact tgttctcctt   2820

tgcatgctag ttttcagaaa tgatgacaaa gagccatatg ttgattggct acaaatgtca   2880

tgttgtatat acagcttctc ccctgggttc gttttgccca gaggaacaca aataaagtgt   2940

tttgtgc                                                             2947


<210>  6224
<211>  503
<212>  PRT
<213>  Homosapiens

<400>  6224

Met Ala Glu Gly Ser Gln Ser Ala Pro Glu Ala Gly Asn Asp Met Gly 
1               5                   10                  15      


Asn Asp Asp Ala Ile Gly Gly Asn Val Ser Lys Tyr Ile Val Leu Pro 
            20                  25                  30          


Thr Gly Tyr Cys Gly Gln Pro Lys Lys Gly His Leu Ile Phe Asp Ala 
        35                  40                  45              


Cys Phe Glu Ser Gly Asn Leu Gly Arg Val Asp Gln Val Ser Glu Phe 
    50                  55                  60                  


Glu Tyr Asp Leu Phe Ile Arg Pro Asp Thr Cys Asn Pro Arg Phe Arg 
65                  70                  75                  80  


Val Trp Phe Asn Phe Thr Val Glu Asn Val Lys Glu Ser Gln Arg Val 
                85                  90                  95      


Ile Phe Asn Ile Val Asn Phe Ser Lys Thr Lys Ser Leu Tyr Arg Asp 
            100                 105                 110         


Gly Met Ala Pro Met Val Lys Ser Thr Ser Arg Pro Lys Trp Gln Arg 
        115                 120                 125             


Leu Pro Pro Lys Asn Val Tyr Tyr Tyr Arg Cys Pro Asp His Arg Lys 
    130                 135                 140                 


Asn Tyr Val Met Ser Phe Ala Phe Cys Phe Asp Arg Glu Glu Asp Ile 
145                 150                 155                 160 


Tyr Gln Phe Ala Tyr Cys Tyr Pro Tyr Thr Tyr Thr Arg Phe Gln His 
                165                 170                 175     


Tyr Leu Asp Ser Leu Gln Lys Arg Asn Met Asp Tyr Phe Phe Arg Glu 
            180                 185                 190         


Gln Leu Gly Gln Ser Val Gln Gln Arg Lys Leu Asp Leu Leu Thr Ile 
        195                 200                 205             


Thr Ser Pro Asp Asn Leu Arg Glu Gly Ala Glu Gln Lys Val Val Phe 
    210                 215                 220                 


Ile Thr Gly Arg Val His Pro Gly Glu Thr Pro Ser Ser Phe Val Cys 
225                 230                 235                 240 


Gln Gly Ile Ile Asp Phe Leu Val Ser Gln His Pro Ile Ala Cys Val 
                245                 250                 255     


Leu Arg Glu Tyr Leu Val Phe Lys Ile Ala Pro Met Leu Asn Pro Asp 
            260                 265                 270         


Gly Val Tyr Leu Gly Asn Tyr Arg Cys Ser Leu Met Gly Phe Asp Leu 
        275                 280                 285             


Asn Arg His Trp Leu Asp Pro Ser Pro Trp Val His Pro Thr Leu His 
    290                 295                 300                 


Gly Val Lys Gln Leu Ile Val Gln Met Tyr Asn Asp Pro Lys Thr Ser 
305                 310                 315                 320 


Leu Glu Phe Tyr Ile Asp Ile His Ala His Ser Thr Met Met Asn Gly 
                325                 330                 335     


Phe Met Tyr Gly Asn Ile Phe Glu Asp Glu Glu Arg Phe Gln Arg Gln 
            340                 345                 350         


Ala Ile Phe Pro Lys Leu Leu Cys Gln Asn Ala Glu Asp Phe Ser Tyr 
        355                 360                 365             


Ser Ser Thr Ser Phe Asn Arg Asp Ala Val Lys Ala Gly Thr Gly Arg 
    370                 375                 380                 


Arg Phe Leu Gly Gly Leu Leu Asp His Thr Ser Tyr Cys Tyr Thr Leu 
385                 390                 395                 400 


Glu Val Ser Phe Tyr Ser Tyr Ile Ile Ser Gly Thr Thr Ala Ala Val 
                405                 410                 415     


Pro Tyr Thr Glu Glu Ala Tyr Met Lys Leu Gly Arg Asn Val Ala Arg 
            420                 425                 430         


Thr Phe Leu Asp Tyr Tyr Arg Leu Asn Pro Val Val Glu Lys Val Ala 
        435                 440                 445             


Ile Pro Met Pro Arg Leu Arg Asn Lys Glu Ile Glu Val Gln Arg Arg 
    450                 455                 460                 


Lys Glu Lys Ser Pro Pro Tyr Lys His Pro Leu Leu Arg Gly Pro Ala 
465                 470                 475                 480 


Ser Asn Tyr Pro Asn Ser Lys Gly Asp Lys Lys Ser Ser Val Asn His 
                485                 490                 495     


Lys Asp Pro Ser Thr Pro Phe 
            500             


<210>  6225
<211>  3938
<212>  DNA
<213>  Homosapiens

<400>  6225
accgagaaga agatatttac cagtttgctt actgctaccc atatacatac actcgcttcc     60

aacattacct tgacagcctg caaaagagaa acatggatta cttctttcgg gagcagctgg    120

gccagagtgt gcaacaacga aagcttgacc tcctgacgat aaccagccct gacaatctcc    180

gggaaggggc agagcagaag gtggtattca tcacaggacg agtccaccca ggggaaacac    240

cctcatcatt tgtgtgccaa gggatcattg acttccttgt aagccagcac cctattgcct    300

gtgtcctccg ggaatacctg gtcttcaaga tcgcaccaat gctcaatcct gatggagtct    360

acctgggcaa ttacaggtgt tctctgatgg gatttgatct gaatcgtcac tggctggatc    420

cctctccatg ggtccatcct accctgcatg gagtgaaaca actcatcgtc cagatgtaca    480

acgacccaaa aacaagcctg gagttttata ttgacatcca tgcccactcc accatgatga    540

atggcttcat gtatggcaac atctttgagg atgaggaacg gttccagagg caggccattt    600

ttcccaagct cctctgccag aatgctgagg acttctccta ttccagcaca tcctttaacc    660

gggacgctgt gaaagcagga actggccgtc gcttcctcgg tggactcctg gaccacactt    720

cctattgcta caccctagag gtctccttct acagctacat catcagtggc accacggctg    780

ctgtgcccta cactgaagaa gcctgtatcc ttagtcccca cccagccttg ggccagccct    840

catccagccg agagtatcca agtctgacag gtcaggaatt aggcccccag ctcaggtaag    900

ggctgagact ctcaggtgag gatggaggtg cttcttcttc tggtggcgtc tttggattgt    960

ccagtttgcc tcagccctta gtatgatact cctaccccaa ttgccatgct ccaaatcttt   1020

cccaggccag ccggacccat ggcctgccca tatcttactc tgcttccatc tctctcccct   1080

ctcttctctc atgatgcagt gagtctcctg ccatctaagc tatgcaagtc cacaggctgg   1140

atgaccatcc ccagggttgc tgaggaagag cttgatgatc ttgactcctt ctaaccctga   1200

acatacaaaa acatatgttc tcttttcatc ttttgtctaa cctatcctct cccactttct   1260

cttccctcta ctcactattt ccccttctac ttacttttct cacccttgtt ccctctcctt   1320

ctatgccctc ctcctccctc ctcacctgtc ctgtgcttct ctttccttac ttctttttcc   1380

ccctcctccc ctcctttctg tcctctctct catcccatcc tccttttctt tctctcctct   1440

ttgcctgtct tctgtcttcc ttgtctttcc cctctcatcc tctgtgcatc tttctctctg   1500

cctttgcatt tcctttgaca aattcctttt cctcttagtt tcttcataaa atttctctga   1560

aaactccaaa gccttccatg atgaaattag aagttatttt ctagtttgcc taatttttta   1620

aggattaggt agtaactcta gtttcccgag tgttgatttt aatatcaagg tcactgcatc   1680

agagctgtaa cagatcgtgg cagattctgc tttccttgat cctttgtttt cgggttgatc   1740

tatgtctcct ttcctaacac ttagttttct cagagaagtg gagggaggag gaaggaactt   1800

tagatgaaat gaactctgta tttctgcaaa ttccccctcc ctggaggtag aagtgctctt   1860

ttagcatttt ttcaaccctt ggtgagtgtt tatggaattc ctctgtgcag gaaaacatct   1920

tttctgaacg tggcatgact tagggctagt cccaccagcc aactgcaact tagtggctct   1980

gtttgtatgt gtgtttggga gggttggggg tatggtgtcc aggtaccttg ccaggaacat   2040

cggaagtagg gcaatggccc tagaaggagg ggctgtcagg gggtaggcca ggtgttagag   2100

caatgttcca catcctgttg gacacagaga tattatgatt ggaactgaga gttccctatg   2160

tacagtcatc aagactgagg gtcatcttgc agtctgcttt aatacccacc tgactcagca   2220

aggccaaggg agtaggctct gctctgagga agagggtctg tgggttccaa agtcctggcc   2280

acctgttatg tgccacattg cccctcttca tgccccatac acaccttaga tgatgcatat   2340

ggcctatgcc ttctccagaa tctgctaact cctataacac atgcatatgc ttcattccac   2400

attgtacttg ctttgctctc ccataatatt atggcaaagg gacagagagc tgcctggaat   2460

aagagtttga gcttgtgcac taaaggggat tctgcaaccc ttattcatag tgagatgagg   2520

gtccctccag aggaggcctg cccttagttt gttgtttttt gctgtccaat ctgacaggct   2580

ctcctacctt ttcttagcac ttctgacatg cttctgtctt agaagaaaat gtgtttctta   2640

gtagaaagcc cacccttggt tcaggcccaa ggtttccacc cctcaacagc caacactcat   2700

ttatcaaaag taaacacagc attagtacat accaggaatc ataaaaggca cctagggtaa   2760

aatactgaat aaaaaggcat gattcctgac tcacagaact ttcagtctac ttggggagac   2820

agaaaaggga agagataatt acaatgtatg tgataaattc tggtggagga attccagaag   2880

gctctgggac attttcattt gacaagtata tattgagtgc ctgtcatagg tcaggtaaag   2940

ttctaggcac agggaatgta acagagaaca tactaaagac aagaatgtct ttacatgggg   3000

gaaagaggga actcacacgc agtcctagga gtcagggaag atttcccagg aaaagagaca   3060

tctaaactga gattttttgt ttgtttgttt ttgagatgga gtctcactct gttacccagg   3120

ctagagtgta gtggcatgat ctcagctcac tgcaacttct gcctcctggg ttcaagcgat   3180

tcccctgcct cagcctcctg agtagctggg attacaggtg tgcgccacca tgtccggcta   3240

atttttgtat ttttagcaga gatggggttt taccatgttg gtcaggctgg tctcaaactt   3300

ctgacctcgt gatccacctg cttcggcctc ccaaagtgct gagattacag gtgtaagcca   3360

ctgagcccgg cctaaactga gtttttaata tgaactagtc aaactgggtg agggtgttgt   3420

tgaagggagg atgtggtaga cagagagggg agtacagaag gtatgggcag aagctgtaag   3480

tggtccctta gggctgaagg acttcagact caatgataag tctgaagtgg aaagatgtaa   3540

gaagtttgat cttgaatgta gacaatggaa ggacagattc gagggggcca gtattgtaga   3600

cagggacatg cattaggagg ctgttataaa aatccaggtg agaaataatc caggccaaga   3660

ccagagtggt ggctgtagaa tacttagaat gtggaactga gaagacttgg taattgacta   3720

tttgggagtg gcgacaggga atgggagctc gtgattggaa ggggttaagg tgagtagaga   3780

ggctatgcac aagctgagca ggtcgtgata ctgatggacc taccctgcct tgttctgtcc   3840

tctagaggat gagaagagga aacaaactgc accagggaag ctcaggccga ttcaatgcat   3900

gcaagggtga tttaacctgg gttctgtttg aaatactt                           3938


<210>  6226
<211>  268
<212>  PRT
<213>  Homosapiens

<400>  6226

Met Asp Tyr Phe Phe Arg Glu Gln Leu Gly Gln Ser Val Gln Gln Arg 
1               5                   10                  15      


Lys Leu Asp Leu Leu Thr Ile Thr Ser Pro Asp Asn Leu Arg Glu Gly 
            20                  25                  30          


Ala Glu Gln Lys Val Val Phe Ile Thr Gly Arg Val His Pro Gly Glu 
        35                  40                  45              


Thr Pro Ser Ser Phe Val Cys Gln Gly Ile Ile Asp Phe Leu Val Ser 
    50                  55                  60                  


Gln His Pro Ile Ala Cys Val Leu Arg Glu Tyr Leu Val Phe Lys Ile 
65                  70                  75                  80  


Ala Pro Met Leu Asn Pro Asp Gly Val Tyr Leu Gly Asn Tyr Arg Cys 
                85                  90                  95      


Ser Leu Met Gly Phe Asp Leu Asn Arg His Trp Leu Asp Pro Ser Pro 
            100                 105                 110         


Trp Val His Pro Thr Leu His Gly Val Lys Gln Leu Ile Val Gln Met 
        115                 120                 125             


Tyr Asn Asp Pro Lys Thr Ser Leu Glu Phe Tyr Ile Asp Ile His Ala 
    130                 135                 140                 


His Ser Thr Met Met Asn Gly Phe Met Tyr Gly Asn Ile Phe Glu Asp 
145                 150                 155                 160 


Glu Glu Arg Phe Gln Arg Gln Ala Ile Phe Pro Lys Leu Leu Cys Gln 
                165                 170                 175     


Asn Ala Glu Asp Phe Ser Tyr Ser Ser Thr Ser Phe Asn Arg Asp Ala 
            180                 185                 190         


Val Lys Ala Gly Thr Gly Arg Arg Phe Leu Gly Gly Leu Leu Asp His 
        195                 200                 205             


Thr Ser Tyr Cys Tyr Thr Leu Glu Val Ser Phe Tyr Ser Tyr Ile Ile 
    210                 215                 220                 


Ser Gly Thr Thr Ala Ala Val Pro Tyr Thr Glu Glu Ala Cys Ile Leu 
225                 230                 235                 240 


Ser Pro His Pro Ala Leu Gly Gln Pro Ser Ser Ser Arg Glu Tyr Pro 
                245                 250                 255     


Ser Leu Thr Gly Gln Glu Leu Gly Pro Gln Leu Arg 
            260                 265             


<210>  6227
<211>  2119
<212>  DNA
<213>  Homosapiens

<400>  6227
caggggcgga ggcggcggcc agggaggaag cggaggaggc ggaggcggcc gcggcgttcg     60

cccgcccgct cgctcgctcg gtttccccgc ccccgccggg cttaacgccg ctgaaggtat    120

ccgggtgcgc gctgtcgcaa cctgccctca tcctggcccg cgactgtaag accggaccca    180

catccagacc aatcttcctg tccgggctgc tgcgacgcgg gctccgcagg ttgcaggcgg    240

gcggccgggg cgcctgaagg ttaccgagtg catgagcgcc tagcgcttcc cgcgctgccc    300

cgcccgctgg cccgccgacc cgcccgccgg ctcgcccgcc agcccctcgg cgcccggcgg    360

cggcggcggc ggtggcggcg acggtcgcag gaggtgccgt ctgcctccca ggtgcgcgct    420

tcgctcccgg agccgcggaa ctcggcggcc gccatggcgt ccaacatgga ccgggagatg    480

atcctggcgg attttcaggc atgtactggc attgaaaaca ttgacgaagc tattacattg    540

cttgaacaaa ataattggga cttagtggca gctatcaatg gtgtaatacc acaggaaaat    600

ggcattctac aaagtgaata tggaggtgag accataccag gacctgcatt taatccagca    660

agtcatccag cttcagctcc tacttcctct tcttcttcag cgtttcgacc tgtaatgcca    720

tccaggcaga ttgtagaaag gcaacctcgg atgctggact tcagggttga atacagagac    780

agaaatgttg atgtggtact tgaagacacc tgtactgttg gagagattaa acagattcta    840

gaaaatgaac ttcagatacc tgtgtccaaa atgctgttaa aaggctggaa gacgggagat    900

gtggaagaca gtacggtcct aaaatctcta cacttgccaa aaaacaacag tctttatgtc    960

cttacaccag atttgccacc accttcatca tctagtcatg ctgggtaatt tttcctatag   1020

atatggtgat tgccatcctg tattttttat tggctcatta gaagctgctt ttcaagaggc   1080

cttctatgtg aaagcccgag atagaaagct tcttgctatc tacctccacc atgatgaaag   1140

tgtgttaacc aacgtgttct gctcacaaat gctttgtgct gaatccattg tttcttatct   1200

gagtcaaaat tttataacct gggcttggga tctgacaaag gactccaaca gagcaagatt   1260

tctcactatg tgcaatagac actttggcag tgttgtggca caaaccattc ggactcaaaa   1320

aacggatcag tttccgcttt tcctgattat tatgggaaag cgatcatcta atgaagtgtt   1380

gaatgtgata caagggaaca caacagtaga tgagttaatg atgagactca tggctgcaat   1440

ggagatcttc acagcccaac aacaggaaga tataaaggac gaggatgaac gtgaagccag   1500

agaaaatgtg aagagagagc aagatgaggc ctatcgcctt tcacttgagg ctgacagagc   1560

aaagagggaa gctcacgaga gagagatggc agaacagttt cgtttggagc agattcgcaa   1620

agaacaagaa gaggaacgtg aggccatccg gctgtcctta gagcaagccc tgcctcctga   1680

gccaaaggaa gaaaatgctg agcctgtgag caaactgcgg atccggaccc ccagtggcga   1740

gttcttggag cggcgtttcc tggccagcaa caagctccag attgtctttg attttgtagc   1800

ttccaaagga tttccatggg atgagtacaa gttactgagc acctttccta ggagagacgt   1860

aactcaactg gacccaaata aatcattatt ggaggtaaag ttgttccctc aagaaaccct   1920

tttccttgaa gcaaaagagt aaacacggcc cagcggtgga accagccatt ccttgacaag   1980

ccagcagcct gcgtcaggag aagggctcct cgccaaccca cccacacgct cgtctcactc   2040

aattcaatgt cacacttctg cctcttgcaa aattgctgga aaaagtaata ataaatatag   2100

ctacttaaga tttcccatc                                                2119


<210>  6228
<211>  328
<212>  PRT
<213>  Homosapiens

<400>  6228

Met Ser Leu His Gln Ile Cys His His Leu His His Leu Val Met Leu 
1               5                   10                  15      


Gly Asn Phe Ser Tyr Arg Tyr Gly Asp Cys His Pro Val Phe Phe Ile 
            20                  25                  30          


Gly Ser Leu Glu Ala Ala Phe Gln Glu Ala Phe Tyr Val Lys Ala Arg 
        35                  40                  45              


Asp Arg Lys Leu Leu Ala Ile Tyr Leu His His Asp Glu Ser Val Leu 
    50                  55                  60                  


Thr Asn Val Phe Cys Ser Gln Met Leu Cys Ala Glu Ser Ile Val Ser 
65                  70                  75                  80  


Tyr Leu Ser Gln Asn Phe Ile Thr Trp Ala Trp Asp Leu Thr Lys Asp 
                85                  90                  95      


Ser Asn Arg Ala Arg Phe Leu Thr Met Cys Asn Arg His Phe Gly Ser 
            100                 105                 110         


Val Val Ala Gln Thr Ile Arg Thr Gln Lys Thr Asp Gln Phe Pro Leu 
        115                 120                 125             


Phe Leu Ile Ile Met Gly Lys Arg Ser Ser Asn Glu Val Leu Asn Val 
    130                 135                 140                 


Ile Gln Gly Asn Thr Thr Val Asp Glu Leu Met Met Arg Leu Met Ala 
145                 150                 155                 160 


Ala Met Glu Ile Phe Thr Ala Gln Gln Gln Glu Asp Ile Lys Asp Glu 
                165                 170                 175     


Asp Glu Arg Glu Ala Arg Glu Asn Val Lys Arg Glu Gln Asp Glu Ala 
            180                 185                 190         


Tyr Arg Leu Ser Leu Glu Ala Asp Arg Ala Lys Arg Glu Ala His Glu 
        195                 200                 205             


Arg Glu Met Ala Glu Gln Phe Arg Leu Glu Gln Ile Arg Lys Glu Gln 
    210                 215                 220                 


Glu Glu Glu Arg Glu Ala Ile Arg Leu Ser Leu Glu Gln Ala Leu Pro 
225                 230                 235                 240 


Pro Glu Pro Lys Glu Glu Asn Ala Glu Pro Val Ser Lys Leu Arg Ile 
                245                 250                 255     


Arg Thr Pro Ser Gly Glu Phe Leu Glu Arg Arg Phe Leu Ala Ser Asn 
            260                 265                 270         


Lys Leu Gln Ile Val Phe Asp Phe Val Ala Ser Lys Gly Phe Pro Trp 
        275                 280                 285             


Asp Glu Tyr Lys Leu Leu Ser Thr Phe Pro Arg Arg Asp Val Thr Gln 
    290                 295                 300                 


Leu Asp Pro Asn Lys Ser Leu Leu Glu Val Lys Leu Phe Pro Gln Glu 
305                 310                 315                 320 


Thr Leu Phe Leu Glu Ala Lys Glu 
                325             


<210>  6229
<211>  2583
<212>  DNA
<213>  Homosapiens

<400>  6229
caggggcgga ggcggcggcc agggaggaag cggaggaggc ggaggcggcc gcggcgttcg     60

cccgcccgct cgctcgctcg gtttccccgc ccccgccggg cttaacgccg ctgaaggtat    120

ccgggtgcgc gctgtcgcaa cctgccctca tcctggcccg cgactgtaag accggaccca    180

catccagacc aatcttcctg tccgggctgc tgcgacgcgg gctccgcagg ttgcaggcgg    240

gcggccgggg cgcctgaagg ttaccgagtg catgagcgcc tagcgcttcc cgcgctgccc    300

cgcccgctgg cccgccgacc cgcccgccgg ctcgcccgcc agcccctcgg cgcccggcgg    360

cggcggcggc ggtggcggcg acggtcgcag gaggtgccgt ctgcctccca ggtgcgcgct    420

tcgctcccgg agccgcggaa ctcggcggcc gccatggcgt ccaacatgga ccgggagatg    480

atcctggcgg attttcaggc atgtactggc attgaaaaca ttgacgaagc tattacattg    540

cttgaacaaa ataattggga cttagtggca gctatcaatg gtgtaatacc acaggaaaat    600

ggcattctac aaagtgaata tggaggtgag accataccag gacctgcatt taatccagca    660

agtcatccag cttcagctcc tacttcctct tcttcttcag cgtttcgacc tgtaatgcca    720

tccaggcaga ttgtagaaag gcaacctcgg atgctggact tcagggttga atacagagac    780

agaaatgttg atgtggtact tgaagacacc tgtactgttg gagagattaa acagattcta    840

gaaaatgaac ttcagatacc tgtgtccaaa atgctgttaa aaggctggaa gacgggagat    900

gtggaagaca gtacggtcct aaaatctcta cacttgccaa aaaacaacag tctttatgtc    960

cttacaccag atttgccacc accttcatca tctagtcatg ctggtgccct gcaggagtca   1020

ttaaatcaaa acttcatgct gatcatcacc caccgagaag tccagcggga gtacaacctg   1080

aacttctcag gaagcagtac tattcaagag gtaaagagaa atgtgtatga ccttacaagt   1140

atccccgttc gccaccaatt atgggagggc tggccaactt ctgctacaga cgactcaatg   1200

tgtcttgctg aatcagggct ctcttatccc tgccatcgac ttacagtggg aagaagatct   1260

tcacctgcac agacccggga acagtcggaa gaacaaatca ccgatgttca tatggttagt   1320

gatagcgatg gagatgactt tgaagatgct acagaatttg gggtggatga tggagaagta   1380

tttggcatgg cgtcatctgc cttgagaaaa tctccaatga tgccagaaaa cgcagaaaat   1440

gaaggagatg ccttattaca atttacagca gagttttctt caagatatgg tgattgccat   1500

cctgtatttt ttattggctc attagaagct gcttttcaag aggccttcta tgtgaaagcc   1560

cgagatagaa agcttcttgc tatctacctc caccatgatg aaagtgtgtt aaccaacgtg   1620

ttctgctcac aaatgctttg tgctgaatcc attgtttctt atctgagtca aaattttata   1680

acctgggctt gggatctgac aaaggactcc aacagagcaa gatttctcac tatgtgcaat   1740

agacactttg gcagtgttgt ggcacaaacc attcggactc aaaaaacgga tcagtttccg   1800

cttttcctga ttattatggg aaagcgatca tctaatgaag tgttgaatgt gatacaaggg   1860

aacacaacag tagatgagtt aatgatgaga ctcatggctg caatggagat cttcacagcc   1920

caacaacagg aagatataaa ggacgaggat gaacgtgaag ccagagaaaa tgtgaagaga   1980

gagcaagatg aggcctatcg cctttcactt gaggctgaca gagcaaagag ggaagctcac   2040

gagagagaga tggcagaaca gtttcgtttg gagcagattc gcaaagaaca agaagaggaa   2100

cgtgaggcca tccggctgtc cttagagcaa gccctgcctc ctgagccaaa ggaagaaaat   2160

gctgagcctg tgagcaaact gcggatccgg acccccagtg gcgagttctt ggagcggcgt   2220

ttcctggcca gcaacaagct ccagattgtc tttgattttg tagcttccaa aggatttcca   2280

tgggatgagt acaagttact gagcaccttt cctaggagag acgtaactca actggaccca   2340

aataaatcat tattggaggt aaagttgttc cctcaagaaa cccttttcct tgaagcaaaa   2400

gagtaaacac ggcccagcgg tggaaccagc cattccttga caagccagca gcctgcgtca   2460

ggagaagggc tcctcgccaa cccacccaca cgctcgtctc actcaattca atgtcacact   2520

tctgcctctt gcaaaattgc tggaaaaagt aataataaat atagctactt aagatttccc   2580

atc                                                                 2583


<210>  6230
<211>  650
<212>  PRT
<213>  Homosapiens

<400>  6230

Met Ala Ser Asn Met Asp Arg Glu Met Ile Leu Ala Asp Phe Gln Ala 
1               5                   10                  15      


Cys Thr Gly Ile Glu Asn Ile Asp Glu Ala Ile Thr Leu Leu Glu Gln 
            20                  25                  30          


Asn Asn Trp Asp Leu Val Ala Ala Ile Asn Gly Val Ile Pro Gln Glu 
        35                  40                  45              


Asn Gly Ile Leu Gln Ser Glu Tyr Gly Gly Glu Thr Ile Pro Gly Pro 
    50                  55                  60                  


Ala Phe Asn Pro Ala Ser His Pro Ala Ser Ala Pro Thr Ser Ser Ser 
65                  70                  75                  80  


Ser Ser Ala Phe Arg Pro Val Met Pro Ser Arg Gln Ile Val Glu Arg 
                85                  90                  95      


Gln Pro Arg Met Leu Asp Phe Arg Val Glu Tyr Arg Asp Arg Asn Val 
            100                 105                 110         


Asp Val Val Leu Glu Asp Thr Cys Thr Val Gly Glu Ile Lys Gln Ile 
        115                 120                 125             


Leu Glu Asn Glu Leu Gln Ile Pro Val Ser Lys Met Leu Leu Lys Gly 
    130                 135                 140                 


Trp Lys Thr Gly Asp Val Glu Asp Ser Thr Val Leu Lys Ser Leu His 
145                 150                 155                 160 


Leu Pro Lys Asn Asn Ser Leu Tyr Val Leu Thr Pro Asp Leu Pro Pro 
                165                 170                 175     


Pro Ser Ser Ser Ser His Ala Gly Ala Leu Gln Glu Ser Leu Asn Gln 
            180                 185                 190         


Asn Phe Met Leu Ile Ile Thr His Arg Glu Val Gln Arg Glu Tyr Asn 
        195                 200                 205             


Leu Asn Phe Ser Gly Ser Ser Thr Ile Gln Glu Val Lys Arg Asn Val 
    210                 215                 220                 


Tyr Asp Leu Thr Ser Ile Pro Val Arg His Gln Leu Trp Glu Gly Trp 
225                 230                 235                 240 


Pro Thr Ser Ala Thr Asp Asp Ser Met Cys Leu Ala Glu Ser Gly Leu 
                245                 250                 255     


Ser Tyr Pro Cys His Arg Leu Thr Val Gly Arg Arg Ser Ser Pro Ala 
            260                 265                 270         


Gln Thr Arg Glu Gln Ser Glu Glu Gln Ile Thr Asp Val His Met Val 
        275                 280                 285             


Ser Asp Ser Asp Gly Asp Asp Phe Glu Asp Ala Thr Glu Phe Gly Val 
    290                 295                 300                 


Asp Asp Gly Glu Val Phe Gly Met Ala Ser Ser Ala Leu Arg Lys Ser 
305                 310                 315                 320 


Pro Met Met Pro Glu Asn Ala Glu Asn Glu Gly Asp Ala Leu Leu Gln 
                325                 330                 335     


Phe Thr Ala Glu Phe Ser Ser Arg Tyr Gly Asp Cys His Pro Val Phe 
            340                 345                 350         


Phe Ile Gly Ser Leu Glu Ala Ala Phe Gln Glu Ala Phe Tyr Val Lys 
        355                 360                 365             


Ala Arg Asp Arg Lys Leu Leu Ala Ile Tyr Leu His His Asp Glu Ser 
    370                 375                 380                 


Val Leu Thr Asn Val Phe Cys Ser Gln Met Leu Cys Ala Glu Ser Ile 
385                 390                 395                 400 


Val Ser Tyr Leu Ser Gln Asn Phe Ile Thr Trp Ala Trp Asp Leu Thr 
                405                 410                 415     


Lys Asp Ser Asn Arg Ala Arg Phe Leu Thr Met Cys Asn Arg His Phe 
            420                 425                 430         


Gly Ser Val Val Ala Gln Thr Ile Arg Thr Gln Lys Thr Asp Gln Phe 
        435                 440                 445             


Pro Leu Phe Leu Ile Ile Met Gly Lys Arg Ser Ser Asn Glu Val Leu 
    450                 455                 460                 


Asn Val Ile Gln Gly Asn Thr Thr Val Asp Glu Leu Met Met Arg Leu 
465                 470                 475                 480 


Met Ala Ala Met Glu Ile Phe Thr Ala Gln Gln Gln Glu Asp Ile Lys 
                485                 490                 495     


Asp Glu Asp Glu Arg Glu Ala Arg Glu Asn Val Lys Arg Glu Gln Asp 
            500                 505                 510         


Glu Ala Tyr Arg Leu Ser Leu Glu Ala Asp Arg Ala Lys Arg Glu Ala 
        515                 520                 525             


His Glu Arg Glu Met Ala Glu Gln Phe Arg Leu Glu Gln Ile Arg Lys 
    530                 535                 540                 


Glu Gln Glu Glu Glu Arg Glu Ala Ile Arg Leu Ser Leu Glu Gln Ala 
545                 550                 555                 560 


Leu Pro Pro Glu Pro Lys Glu Glu Asn Ala Glu Pro Val Ser Lys Leu 
                565                 570                 575     


Arg Ile Arg Thr Pro Ser Gly Glu Phe Leu Glu Arg Arg Phe Leu Ala 
            580                 585                 590         


Ser Asn Lys Leu Gln Ile Val Phe Asp Phe Val Ala Ser Lys Gly Phe 
        595                 600                 605             


Pro Trp Asp Glu Tyr Lys Leu Leu Ser Thr Phe Pro Arg Arg Asp Val 
    610                 615                 620                 


Thr Gln Leu Asp Pro Asn Lys Ser Leu Leu Glu Val Lys Leu Phe Pro 
625                 630                 635                 640 


Gln Glu Thr Leu Phe Leu Glu Ala Lys Glu 
                645                 650 


<210>  6231
<211>  895
<212>  DNA
<213>  Homosapiens

<400>  6231
cattttgagg ccacttttga aatagaacca atatttttgc catttcagaa aaattgtcgt     60

ctgtgtgcca aagacagaga gcatgcagta aaagtgcacc atagcatgga tgttggactc    120

aagcagggct cacttactag gcaggtgact tgttcctgaa aaccagtctg gctgtgaaca    180

tcatccagat cctcacctca gcaaaatcac agtctgtcat taactgaagc aaatgaaaat    240

tctaaacttt atgagggcat aatactcagc aaagaacaca aatcctaaca gtatagtttg    300

aatttgcaca acatgaacac atccatataa acaactcttt ggttaaaaga acagaatatg    360

taacgagtag aaaaaagaaa aagaggagat tagggcacat agagacacaa ggaagaacaa    420

tgtgaacaca gggaggagac agccatcaac aagccaagaa gagaggcccc agaagacacg    480

caaactgctg acaccttgat attggatttc tagtctcaga attgcatgta ctggcattga    540

aaacattgac gaagctatta cattgcttga acaaaataat tgggacttag tggcagctat    600

caatggtgta ataccacagg aaaatggcat tctacaaagt gaatatggag gtgagaccat    660

accaggacct gcatttaatc cagcaagtca tccagcttca gctcctactt cctcttcttc    720

ttcagcgttt cgacctgtaa tgccatccag gcagattgta gaaaggcaac ctcggatgct    780

ggacttcagg gttgaataca gagacagaaa tgttgatgtg gtacttgaag acacctgtac    840

tgttggtaag gtttttcctg ccataaagcc ttcacaaata aataattagg taaac         895


<210>  6232
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  6232

Met Ala Phe Tyr Lys Val Asn Met Glu Val Arg Pro Tyr Gln Asp Leu 
1               5                   10                  15      


His Leu Ile Gln Gln Val Ile Gln Leu Gln Leu Leu Leu Pro Leu Leu 
            20                  25                  30          


Leu Gln Arg Phe Asp Leu 
        35              


<210>  6233
<211>  2906
<212>  DNA
<213>  Homosapiens

<400>  6233
aacacagaag taaccagact gccatggtag acatgggaga gacgaggaag ctgagaaagg     60

actatttcgc agtttccagt ccttgattaa ttaaggcttc agagttcgtt cttacatatg    120

ccatgtctta agttttcata aaattcagtc tacacaagac ttgctttttg tgagcactgt    180

gcttagtggc agtccggatt tttccctcca cccccgcggc cacccctgcc caccgcgccg    240

tcgggcatgg atctggcagg tgcgaggccg aggccagggc tcagcgaagg acgccgagtt    300

tacagagcgc gcgcgcctag aggaggcagc agcagccgca gcctggccgc ccgaactttg    360

cgagcctggc gggggagcac agaggcgggc cgacctgccc cgctagcgct gaggaacgac    420

tccctttatg ccagctcgct gtccgccttc ccgcagcgta cgctgcggag cctcaaagac    480

cctgcggccc tccacaaccg tcttaaataa caaacccctg tcctcgcccc cgtaggaatt    540

ggggcagctg ggggttcgcg tcacagactc aagcccgcca gcagaagggc aggccggact    600

tcgcggggcc gaaccccgct ccagctgggg acaggccgcc tagccggcag gagggagccg    660

gcgcgagaga cttgacggga ggaggtggag agcgggaggc gggaatgagg gcgcgggacc    720

gggcgggcgg agcgtgcgag actgcgagcg cgagcgccag cagggcggag ggcggggcgt    780

gggcggcgcc cggccttccc gctcccgcgg cgctgcaact ctgccgagcc tccttaaaac    840

tctgccgtta aaatgggggc gggtttttca actcaaaaag cgctcaattt ttttcttttc    900

aaaaaaagct gatgaggtcg gaaaaaaggg agaagaaacc ggcaccctct ctgagaggca    960

acagaagcag caattgtttc agcgaaaaaa gcagcaaggg agggagtgaa ggaaaaaagc   1020

aaaaaagggg gcgacacgca agtgcctgta ggggtgaaag gagcagggac cggcgatcta   1080

gggggggatc agctacaaaa gaaactgtca ctgggagcgg tgcggccaag gaggaagcag   1140

tgctgccagg ctctgctcca gggcacagct ggctggcggc tgccctgtcc gcagcaaagg   1200

ggcacaggcc ggggaccgcg agaggtggca aagtggcacc gggcgccgag gctgctgagc   1260

gctcgccgag acggcgaccg gactggctgc cccggaactg cggcgactct ccctactcag   1320

aacttggcct acgtttccca ggactctccc catctccaga ggcccccaca aaaccgggaa   1380

aggaaggaaa ggacagcggc ggcagcagct caatgagtgc ctacagcaga aagcctgaac   1440

gagctcggtc gtaggcggga agttcccggg ggggctgccc agtgcagccg caatgctgcc   1500

gcgagctgcc ccagcagtcc gggctccgta gacgctttcc gcatcactct ccttcctcgg   1560

gctgccggga gtcccgggac ctggcggggc cggcatgacg ggcttctcgg gggcccgccg   1620

cacgcccggc agcctccgga gacgcgcgcc gagcccggct cccacggcct ctgaggctcg   1680

gcggggctgc ggctgcctgg cgggcgggct ccggagcttt cctgagcggc attagcccac   1740

ggcttggccc ggacgcgacc aaaggctctt ctggagaagc ccagagcact gggcaatcgt   1800

tacgacctgt aacttgaggg ccaccgaact gctactcccg ttcgcctttg gcgatcatct   1860

tttaaccctc cggagcacgt cagcatccag ccaccgcggc gctctcccag cagcggagga   1920

cccaggacta tcccttcggc gagacggatg gaaaccgagc cccctggagg acctgcccct   1980

gcagttctgc ctcacacggc tcaagtcacc accgtgaaca agggacccta aagaatggcc   2040

gagccttggg ggaacgagtt ggcgtccgca gctgccaggg gggacctaga gcaacttact   2100

agtttgttgc aaaataatgt aaacgtcaat gcacaaaatg gatttggaag gactgcgctg   2160

caggttatga aacttggaaa tcccgagatt gccaggagac tgctacttag aggtgctaat   2220

cccgatttga aagaccgaac tggtttcgct gtcattcatg atgcggccag agcaggtttc   2280

ctggacactt tacagacttt gctggagttt caagctgatg ttaacatcga ggataatgaa   2340

gggaacctgc ccttgcactt ggctgccaaa gaaggccacc tccgggtggt ggagttcctg   2400

gtgaagcaca cggccagcaa tgtggggcat cggaaccata agggggacac cgcctgtgat   2460

ttggccaggc tctatgggag gaatgaggtt gttagcctga tgcaggcaaa cggggctggg   2520

ggagccacaa atcttcaata aacgtgggga gggctccccc acgttgcctc tactttatca   2580

attaactgag tagctctcct gacttttaat gtcatttgtt aaaatacagt tctgtcatat   2640

gttaagcagc taaattttct gaaactgcat aagtgaaaat cttacaacag gcttatgaat   2700

atatttaagc aacatctttt taacctgcaa aatctgttct aacatgtaat tgcagataac   2760

tttgactttc ttctgaatat tttatctttc cttggctttt cccttgcttc cccttttgcc   2820

aatctcaaca cccaagttga agactttgtt tttaaaatgg tttgtcctga tgcttttgtc   2880

taattaaaac actttcaaaa caggac                                        2906


<210>  6234
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  6234

Met Ala Glu Pro Trp Gly Asn Glu Leu Ala Ser Ala Ala Ala Arg Gly 
1               5                   10                  15      


Asp Leu Glu Gln Leu Thr Ser Leu Leu Gln Asn Asn Val Asn Val Asn 
            20                  25                  30          


Ala Gln Asn Gly Phe Gly Arg Thr Ala Leu Gln Val Met Lys Leu Gly 
        35                  40                  45              


Asn Pro Glu Ile Ala Arg Arg Leu Leu Leu Arg Gly Ala Asn Pro Asp 
    50                  55                  60                  


Leu Lys Asp Arg Thr Gly Phe Ala Val Ile His Asp Ala Ala Arg Ala 
65                  70                  75                  80  


Gly Phe Leu Asp Thr Leu Gln Thr Leu Leu Glu Phe Gln Ala Asp Val 
                85                  90                  95      


Asn Ile Glu Asp Asn Glu Gly Asn Leu Pro Leu His Leu Ala Ala Lys 
            100                 105                 110         


Glu Gly His Leu Arg Val Val Glu Phe Leu Val Lys His Thr Ala Ser 
        115                 120                 125             


Asn Val Gly His Arg Asn His Lys Gly Asp Thr Ala Cys Asp Leu Ala 
    130                 135                 140                 


Arg Leu Tyr Gly Arg Asn Glu Val Val Ser Leu Met Gln Ala Asn Gly 
145                 150                 155                 160 


Ala Gly Gly Ala Thr Asn Leu Gln 
                165             


<210>  6235
<211>  3142
<212>  DNA
<213>  Homosapiens

<400>  6235
aacacagaag taaccagact gccatggtag acatgggaga gacgaggaag ctgagaaagg     60

actatttcgc agtttccagt ccttgattaa ttaaggcttc agagttcgtt cttacatatg    120

ccatgtctta agttttcata aaattcagtc tacacaagac ttgctttttg tgagcactgt    180

gcttagtggc agtccggatt tttccctcca cccccgcggc cacccctgcc caccgcgccg    240

tcgggcatgg atctggcagg tgcgaggccg aggccagggc tcagcgaagg acgccgagtt    300

tacagagcgc gcgcgcctag aggaggcagc agcagccgca gcctggccgc ccgaactttg    360

cgagcctggc gggggagcac agaggcgggc cgacctgccc cgctagcgct gaggaacgac    420

tccctttatg ccagctcgct gtccgccttc ccgcagcgta cgctgcggag cctcaaagac    480

cctgcggccc tccacaaccg tcttaaataa caaacccctg tcctcgcccc cgtaggaatt    540

ggggcagctg ggggttcgcg tcacagactc aagcccgcca gcagaagggc aggccggact    600

tcgcggggcc gaaccccgct ccagctgggg acaggccgcc tagccggcag gagggagccg    660

gcgcgagaga cttgacggga ggaggtggag agcgggaggc gggaatgagg gcgcgggacc    720

gggcgggcgg agcgtgcgag actgcgagcg cgagcgccag cagggcggag ggcggggcgt    780

gggcggcgcc cggccttccc gctcccgcgg cgctgcaact ctgccgagcc tccttaaaac    840

tctgccgtta aaatgggggc gggtttttca actcaaaaag cgctcaattt ttttcttttc    900

aaaaaaagct gatgaggtcg gaaaaaaggg agaagaaacc ggcaccctct ctgagaggca    960

acagaagcag caattgtttc agcgaaaaaa gcagcaaggg agggagtgaa ggaaaaaagc   1020

aaaaaagggg gcgacacgca agtgcctgta ggggtgaaag gagcagggac cggcgatcta   1080

gggggggatc agctacaaaa gaaactgtca ctgggagcgg tgcggccaag gaggaagcag   1140

tgctgccagg ctctgctcca gggcacagct ggctggcggc tgccctgtcc gcagcaaagg   1200

ggcacaggcc ggggaccgcg agaggtggca aagtggcacc gggcgccgag gctgctgagc   1260

gctcgccgag acggcgaccg gactggctgc cccggaactg cggcgactct ccctactcag   1320

aacttggcct acgtttccca ggactctccc catctccaga ggcccccaca aaaccgggaa   1380

aggaaggaaa ggacagcggc ggcagcagct caatgagtgc ctacagcaga aagcctgaac   1440

gagctcggtc gtaggcggga agttcccggg ggggctgccc agtgcagccg caatgctgcc   1500

gcgagctgcc ccagcagtcc gggctccgta gacgctttcc gcatcactct ccttcctcgg   1560

gctgccggga gtcccgggac ctggcggggc cggcatgacg ggcttctcgg gggcccgccg   1620

cacgcccggc agcctccgga gacgcgcgcc gagcccggct cccacggcct ctgaggctcg   1680

gcggggctgc ggctgcctgg cgggcgggct ccggagcttt cctgagcggc attagcccac   1740

ggcttggccc ggacgcgacc aaaggctctt ctggagaagc ccagagcact gggcaatcgt   1800

tacgacctgt aacttgaggg ccaccgaact gctactcccg ttcgcctttg gcgatcatct   1860

tttaaccctc cggagcacgt cagcatccag ccaccgcggc gctctcccag cagcggagga   1920

cccaggacta tcccttcggc gagacggatg gaaaccgagc cccctggagg acctgcccct   1980

gcagttctgc ctcacacggc tcaagtcacc accgtgaaca agggacccta aagaatggcc   2040

gagccttggg ggaacgagtt ggcgtccgca gctgccaggg gggacctaga gcaacttact   2100

agtttgttgc aaaataatgt aaacgtcaat gcacaaaatg gatttggaag gactgcgctg   2160

caggttatga aacttggaaa tcccgagatt gccaggagac tgctacttag aggtgctaat   2220

cccgatttga aagaccgaac tggtttcgct gtcattcatg atgcggccag agcaggtttc   2280

ctggacactt tacagacttt gctggagttt caagctgatg ttaacatcga ggataatgaa   2340

gggaacctgc ccttgcactt ggctgccaaa gaaggccacc tccgggtggt ggagttcctg   2400

gtgaagcaca cggccagcaa tgtggggcat cggaaccata agggggacac cgcctgtgat   2460

ttggccaggc tctatgggag gaatgaggtt gttagcctga tgcaggcaaa cggggctggg   2520

ggagccacaa atcttcaata aacgtgggga gggctccccc acgttgcctc tactttatca   2580

attaactgag tagctctcct gacttttaat gtcatttgtt aaaatacagt tctgtcatat   2640

gttaagcagc taaattttct gaaactgcat aagtgaaaat cttacaacag gcttatgaat   2700

atatttaagc aacatctttt taacctgcaa aatctgttct aacatgtaat tgcagataac   2760

tttgactttc ttctgaatat tttatctttc cttggctttt cccttgcttc cccttttgcc   2820

aatctcaaca cccaagttga agactttgtt tttaaaatgg tttgtcctga tgcttttgtc   2880

taattaaaac actttcaaaa caggacaaca tttttctgtg attttccctc ctttagaacc   2940

catacacaac ttatcacttg ctaaggagaa ctgtactaaa agttattgaa tgtcttaagt   3000

ctttacacta gaaaaggtag accaactgga aaactagaca tactctcttg atgattcagt   3060

tgttttcatc ctttacccat gtcccgtcca ccttggtgcc tagtatttct gctttaaaac   3120

aaaataagga caactttttt tt                                            3142


<210>  6236
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  6236

Met Ala Glu Pro Trp Gly Asn Glu Leu Ala Ser Ala Ala Ala Arg Gly 
1               5                   10                  15      


Asp Leu Glu Gln Leu Thr Ser Leu Leu Gln Asn Asn Val Asn Val Asn 
            20                  25                  30          


Ala Gln Asn Gly Phe Gly Arg Thr Ala Leu Gln Val Met Lys Leu Gly 
        35                  40                  45              


Asn Pro Glu Ile Ala Arg Arg Leu Leu Leu Arg Gly Ala Asn Pro Asp 
    50                  55                  60                  


Leu Lys Asp Arg Thr Gly Phe Ala Val Ile His Asp Ala Ala Arg Ala 
65                  70                  75                  80  


Gly Phe Leu Asp Thr Leu Gln Thr Leu Leu Glu Phe Gln Ala Asp Val 
                85                  90                  95      


Asn Ile Glu Asp Asn Glu Gly Asn Leu Pro Leu His Leu Ala Ala Lys 
            100                 105                 110         


Glu Gly His Leu Arg Val Val Glu Phe Leu Val Lys His Thr Ala Ser 
        115                 120                 125             


Asn Val Gly His Arg Asn His Lys Gly Asp Thr Ala Cys Asp Leu Ala 
    130                 135                 140                 


Arg Leu Tyr Gly Arg Asn Glu Val Val Ser Leu Met Gln Ala Asn Gly 
145                 150                 155                 160 


Ala Gly Gly Ala Thr Asn Leu Gln 
                165             


<210>  6237
<211>  1224
<212>  DNA
<213>  Homosapiens

<400>  6237
gaggccaggg ctcagcgaag gacgccgagt ttacagagcg cgcgcgccta gaggaggcag     60

cagcagccgc agcctggccg cccgaacttt gcgagcctgg cgggggagca cagaggcggg    120

ccgacctgcc ccgctagcgc tgaggaacga ctccctttat gccagctcgc tgtccgcctt    180

cccgcagcgt acgctgcgga gcctcaaaga ccctgcggcc ctccacaacc gtcttaaata    240

acaaacccct gtcctcgccc ccgtaggaat tggggcagct gggggttcgc gtcacagact    300

caagcccgcc agcagaaggg caggccggac ttcgcggggc cgaaccccgc tccagctggg    360

gacaggccgc ctagccggca ggagggagcc ggcgcgagag acttgacggg aggaggtgga    420

gagcgggagg cgggaatgag ggcgcgggac cgggcgggcg gagcgtgcga gactgcgagc    480

gcgagcgcca gcagggcgga gggcggggcg tgggcggcgc ccggccttcc cgctcccgcg    540

gcgctgcaac tctgccgagc ctccttaaaa ctctgccgtt aaaatggggg cgggtttttc    600

aactcaaaaa gcgctcaatt tttttctttt caaaaaaagc tgatgaggtc ggaaaaaagg    660

gagaagaaac cggcaccctc tctgagaggc aacagaagca gcaattgttt cagcgaaaaa    720

agcagcaagg gagggagtga aggaaaaaag caaaaaaggg ggcgacacgc aagtgcctgt    780

aggggtgaaa ggagcaggga ccggcgatct aggggggggc ccgccgcacg cccggcagcc    840

tccggagacg cgcgccgagc ccggctccca cggcctctga ggctcggcgg ggctgcggct    900

gcctggcggg cgggctccgg agctttcctg agcggcatta gcccacggct tggcccggac    960

gcgaccaaag gctcttctgg agaagcccag agcactgggc aatcgttacg acctgtaact   1020

tgagggccac cgaactgcta ctcccgttcg cctttggcga tcatctttta accctccgga   1080

gcacgtcagc atccagccac cgcggcgctc tcccagcagc ggaggaccca ggactatccc   1140

ttcggcgaga cggatggaaa ccgagccccc tggaggacct gcccctgcag ttctgcctca   1200

cacggctcaa gtcaccaccg tgaa                                          1224


<210>  6238
<211>  126
<212>  PRT
<213>  Homosapiens

<400>  6238

Met Arg Ser Glu Lys Arg Glu Lys Lys Pro Ala Pro Ser Leu Arg Gly 
1               5                   10                  15      


Asn Arg Ser Ser Asn Cys Phe Ser Glu Lys Ser Ser Lys Gly Gly Ser 
            20                  25                  30          


Glu Gly Lys Lys Gln Lys Arg Gly Arg His Ala Ser Ala Cys Arg Gly 
        35                  40                  45              


Glu Arg Ser Arg Asp Arg Arg Ser Arg Gly Gly Pro Ala Ala Arg Pro 
    50                  55                  60                  


Ala Ala Ser Gly Asp Ala Arg Arg Ala Arg Leu Pro Arg Pro Leu Arg 
65                  70                  75                  80  


Leu Gly Gly Ala Ala Ala Ala Trp Arg Ala Gly Ser Gly Ala Phe Leu 
                85                  90                  95      


Ser Gly Ile Ser Pro Arg Leu Gly Pro Asp Ala Thr Lys Gly Ser Ser 
            100                 105                 110         


Gly Glu Ala Gln Ser Thr Gly Gln Ser Leu Arg Pro Val Thr 
        115                 120                 125     


<210>  6239
<211>  1621
<212>  DNA
<213>  Homosapiens

<400>  6239
gaggccaggg ctcagcgaag gacgccgagt ttacagagcg cgcgcgccta gaggaggcag     60

cagcagccgc agcctggccg cccgaacttt gcgagcctgg cgggggagca cagaggcggg    120

ccgacctgcc ccgctagcgc tgaggaacga ctccctttat gccagctcgc tgtccgcctt    180

cccgcagcgt acgctgcgga gcctcaaaga ccctgcggcc ctccacaacc gtcttaaata    240

acaaacccct gtcctcgccc ccgtaggaat tggggcagct gggggttcgc gtcacagact    300

caagcccgcc agcagaaggg caggccggac ttcgcggggc cgaaccccgc tccagctggg    360

gacaggccgc ctagccggca ggagggagcc ggcgcgagag acttgacggg aggaggtgga    420

gagcgggagg cgggaatgag ggcgcgggac cgggcgggcg gagcgtgcga gactgcgagc    480

gcgagcgcca gcagggcgga gggcggggcg tgggcggcgc ccggccttcc cgctcccgcg    540

gcgctgcaac tctgccgagc ctccttaaaa ctctgccgtt aaaatggggg cgggtttttc    600

aactcaaaaa gcgctcaatt tttttctttt caaaaaaagc tgatgaggtc ggaaaaaagg    660

gagaagaaac cggcaccctc tctgagaggc aacagaagca gcaattgttt cagcgaaaaa    720

agcagcaagg gagggagtga aggaaaaaag caaaaaaggg ggcgacacgc aagtgcctgt    780

aggggtgaaa ggagcaggga ccggcgatct agggggggat cagctacaaa agaaactgtc    840

actgggagcg gtgcggccaa ggaggaagca gtgctgccag gctctgctcc agggcacagc    900

tggctggcgg ctgccctgtc cgcagcaaag gggcacaggc cggggaccgc gagaggtggc    960

aaagtggcac cgggcgccga ggctgctgag cgctcgccga gacggcgacc ggactggctg   1020

ccccggaact gcggcgactc tccctactca gaacttggcc tacgtttccc aggactctcc   1080

ccatctccag aggcccccac aaaaccggga aaggaaggaa aggacagcgg cggcagcagc   1140

tcaatgagtg cctacagcag aaagccgcct gtgatttggc caggctctat gggaggaatg   1200

aggttgttag cctgatgcag gcaaacgggg ctgggggagc cacaaatctt caataaacgt   1260

ggggagggct cccccacgtt gcctctactt tatcaattaa ctgagtagct ctcctgactt   1320

ttaatgtcat ttgttaaaat acagttctgt catatgttaa gcagctaaat tttctgaaac   1380

tgcataagtg aaaatcttac aacaggctta tgaatatatt taagcaacat ctttttaacc   1440

tgcaaaatct gttctaacat gtaattgcag ataactttga ctttcttctg aatattttat   1500

ctttccttgg cttttccctt gcttcccctt ttgccaatct caacacccaa gttgaagact   1560

ttgtttttaa aatggtttgt cctgatgctt ttgtctaatt aaaacacttt caaaacagga   1620

c                                                                   1621


<210>  6240
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  6240

Met Arg Ser Glu Lys Arg Glu Lys Lys Pro Ala Pro Ser Leu Arg Gly 
1               5                   10                  15      


Asn Arg Ser Ser Asn Cys Phe Ser Glu Lys Ser Ser Lys Gly Gly Ser 
            20                  25                  30          


Glu Gly Lys Lys Gln Lys Arg Gly Arg His Ala Ser Ala Cys Arg Gly 
        35                  40                  45              


Glu Arg Ser Arg Asp Arg Arg Ser Arg Gly Gly Ser Ala Thr Lys Glu 
    50                  55                  60                  


Thr Val Thr Gly Ser Gly Ala Ala Lys Glu Glu Ala Val Leu Pro Gly 
65                  70                  75                  80  


Ser Ala Pro Gly His Ser Trp Leu Ala Ala Ala Leu Ser Ala Ala Lys 
                85                  90                  95      


Gly His Arg Pro Gly Thr Ala Arg Gly Gly Lys Val Ala Pro Gly Ala 
            100                 105                 110         


Glu Ala Ala Glu Arg Ser Pro Arg Arg Arg Pro Asp Trp Leu Pro Arg 
        115                 120                 125             


Asn Cys Gly Asp Ser Pro Tyr Ser Glu Leu Gly Leu Arg Phe Pro Gly 
    130                 135                 140                 


Leu Ser Pro Ser Pro Glu Ala Pro Thr Lys Pro Gly Lys Glu Gly Lys 
145                 150                 155                 160 


Asp Ser Gly Gly Ser Ser Ser Met Ser Ala Tyr Ser Arg Lys Pro Pro 
                165                 170                 175     


Val Ile Trp Pro Gly Ser Met Gly Gly Met Arg Leu Leu Ala 
            180                 185                 190 


<210>  6241
<211>  1857
<212>  DNA
<213>  Homosapiens

<400>  6241
gaggccaggg ctcagcgaag gacgccgagt ttacagagcg cgcgcgccta gaggaggcag     60

cagcagccgc agcctggccg cccgaacttt gcgagcctgg cgggggagca cagaggcggg    120

ccgacctgcc ccgctagcgc tgaggaacga ctccctttat gccagctcgc tgtccgcctt    180

cccgcagcgt acgctgcgga gcctcaaaga ccctgcggcc ctccacaacc gtcttaaata    240

acaaacccct gtcctcgccc ccgtaggaat tggggcagct gggggttcgc gtcacagact    300

caagcccgcc agcagaaggg caggccggac ttcgcggggc cgaaccccgc tccagctggg    360

gacaggccgc ctagccggca ggagggagcc ggcgcgagag acttgacggg aggaggtgga    420

gagcgggagg cgggaatgag ggcgcgggac cgggcgggcg gagcgtgcga gactgcgagc    480

gcgagcgcca gcagggcgga gggcggggcg tgggcggcgc ccggccttcc cgctcccgcg    540

gcgctgcaac tctgccgagc ctccttaaaa ctctgccgtt aaaatggggg cgggtttttc    600

aactcaaaaa gcgctcaatt tttttctttt caaaaaaagc tgatgaggtc ggaaaaaagg    660

gagaagaaac cggcaccctc tctgagaggc aacagaagca gcaattgttt cagcgaaaaa    720

agcagcaagg gagggagtga aggaaaaaag caaaaaaggg ggcgacacgc aagtgcctgt    780

aggggtgaaa ggagcaggga ccggcgatct agggggggat cagctacaaa agaaactgtc    840

actgggagcg gtgcggccaa ggaggaagca gtgctgccag gctctgctcc agggcacagc    900

tggctggcgg ctgccctgtc cgcagcaaag gggcacaggc cggggaccgc gagaggtggc    960

aaagtggcac cgggcgccga ggctgctgag cgctcgccga gacggcgacc ggactggctg   1020

ccccggaact gcggcgactc tccctactca gaacttggcc tacgtttccc aggactctcc   1080

ccatctccag aggcccccac aaaaccggga aaggaaggaa aggacagcgg cggcagcagc   1140

tcaatgagtg cctacagcag aaagccgcct gtgatttggc caggctctat gggaggaatg   1200

aggttgttag cctgatgcag gcaaacgggg ctgggggagc cacaaatctt caataaacgt   1260

ggggagggct cccccacgtt gcctctactt tatcaattaa ctgagtagct ctcctgactt   1320

ttaatgtcat ttgttaaaat acagttctgt catatgttaa gcagctaaat tttctgaaac   1380

tgcataagtg aaaatcttac aacaggctta tgaatatatt taagcaacat ctttttaacc   1440

tgcaaaatct gttctaacat gtaattgcag ataactttga ctttcttctg aatattttat   1500

ctttccttgg cttttccctt gcttcccctt ttgccaatct caacacccaa gttgaagact   1560

ttgtttttaa aatggtttgt cctgatgctt ttgtctaatt aaaacacttt caaaacagga   1620

caacattttt ctgtgatttt ccctccttta gaacccatac acaacttatc acttgctaag   1680

gagaactgta ctaaaagtta ttgaatgtct taagtcttta cactagaaaa ggtagaccaa   1740

ctggaaaact agacatactc tcttgatgat tcagttgttt tcatccttta cccatgtccc   1800

gtccaccttg gtgcctagta tttctgcttt aaaacaaaat aaggacaact ttttttt      1857


<210>  6242
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  6242

Met Arg Ser Glu Lys Arg Glu Lys Lys Pro Ala Pro Ser Leu Arg Gly 
1               5                   10                  15      


Asn Arg Ser Ser Asn Cys Phe Ser Glu Lys Ser Ser Lys Gly Gly Ser 
            20                  25                  30          


Glu Gly Lys Lys Gln Lys Arg Gly Arg His Ala Ser Ala Cys Arg Gly 
        35                  40                  45              


Glu Arg Ser Arg Asp Arg Arg Ser Arg Gly Gly Ser Ala Thr Lys Glu 
    50                  55                  60                  


Thr Val Thr Gly Ser Gly Ala Ala Lys Glu Glu Ala Val Leu Pro Gly 
65                  70                  75                  80  


Ser Ala Pro Gly His Ser Trp Leu Ala Ala Ala Leu Ser Ala Ala Lys 
                85                  90                  95      


Gly His Arg Pro Gly Thr Ala Arg Gly Gly Lys Val Ala Pro Gly Ala 
            100                 105                 110         


Glu Ala Ala Glu Arg Ser Pro Arg Arg Arg Pro Asp Trp Leu Pro Arg 
        115                 120                 125             


Asn Cys Gly Asp Ser Pro Tyr Ser Glu Leu Gly Leu Arg Phe Pro Gly 
    130                 135                 140                 


Leu Ser Pro Ser Pro Glu Ala Pro Thr Lys Pro Gly Lys Glu Gly Lys 
145                 150                 155                 160 


Asp Ser Gly Gly Ser Ser Ser Met Ser Ala Tyr Ser Arg Lys Pro Pro 
                165                 170                 175     


Val Ile Trp Pro Gly Ser Met Gly Gly Met Arg Leu Leu Ala 
            180                 185                 190 


<210>  6243
<211>  1122
<212>  DNA
<213>  Homosapiens

<400>  6243
ccttcccgct cccgcggcgc tgcaactctg ccgagcctcc ttaaaactct gccgttaaaa     60

tgggggcggg tttttcaact caaaaagcgc tcaatttttt tcttttcaaa aaaagctgat    120

gaggtcggaa aaaagggaga agaaaccggc accctctctg agaggcaaca gaagcagcaa    180

ttgtttcagc gaaaaaagca gcaagggagg gagtgaagga aaaaagcaaa aaagggggcg    240

acacgcaagt gcctgtaggg gtgaaaggag cagggaccgg cgatctaggg ggggatcagc    300

tacaaaagaa actgtcactg ggagcggtgc ggccaaggag gaagcagtgc tgctgagcgc    360

tcgccgagac ggcgaccgga ctggctgccc cggaactgcg gcgactctcc ctactcagaa    420

cttggcctac gtttcccagg actctcccca tctccagagg cccccacaaa accgggaaag    480

gaaggaaagg acagcggcgg cagcagctca atgagtgcct acagcagaaa gcctgaacga    540

gctcggtcgt aggcgggaag ttcccggggg ggctgcccag tgcagccgca atgctgccgc    600

gagctgcccc agcagtccgg gctccgtaga cgctttccgc atcactctcc ttcctcgggc    660

tgccgggagt cccgggacct ggcggggccg gcatgacggg cttctcgggg gcccgccgca    720

cgcccggcag cctccggaga cgcgcgccga gcccggctcc cacggcctct gaggctcggc    780

ggggctgcgg ctgcctggcg ggcgggctcc ggagctttcc tgagcggcat tagcccacgg    840

cttggcccgg acgcgaccaa aggctcttct ggagaagccc agagcactgg gcaatcgtta    900

cgacctgtaa cttgagggcc accgaactgc tactcccgtt cgcctttggc gatcatcttt    960

taaccctccg gagcacgtca gcatccagcc accgcggcgc tctcccagca gcggaggacc   1020

caggactatc ccttcggcga gacggatgga aaccgagccc cctggaggac ctgcccctgc   1080

agttctgcct cacacggctc aagtcaccac cgtgaacaag gg                      1122


<210>  6244
<211>  131
<212>  PRT
<213>  Homosapiens

<400>  6244

Met Arg Ser Glu Lys Arg Glu Lys Lys Pro Ala Pro Ser Leu Arg Gly 
1               5                   10                  15      


Asn Arg Ser Ser Asn Cys Phe Ser Glu Lys Ser Ser Lys Gly Gly Ser 
            20                  25                  30          


Glu Gly Lys Lys Gln Lys Arg Gly Arg His Ala Ser Ala Cys Arg Gly 
        35                  40                  45              


Glu Arg Ser Arg Asp Arg Arg Ser Arg Gly Gly Ser Ala Thr Lys Glu 
    50                  55                  60                  


Thr Val Thr Gly Ser Gly Ala Ala Lys Glu Glu Ala Val Leu Leu Ser 
65                  70                  75                  80  


Ala Arg Arg Asp Gly Asp Arg Thr Gly Cys Pro Gly Thr Ala Ala Thr 
                85                  90                  95      


Leu Pro Thr Gln Asn Leu Ala Tyr Val Ser Gln Asp Ser Pro His Leu 
            100                 105                 110         


Gln Arg Pro Pro Gln Asn Arg Glu Arg Lys Glu Arg Thr Ala Ala Ala 
        115                 120                 125             


Ala Ala Gln 
    130     


<210>  6245
<211>  1294
<212>  DNA
<213>  Homosapiens

<400>  6245
attttctgcc ccgatctata gtcccttgag tctccacaca cactcctcac agagatctgt     60

agcgtaggta cgtgacagct ctgcctacat ctgacgtccg gagtcattaa ccaggaatgt    120

atgtgtgtct gtgtgtctct ctgtggagtc gtcagaattc ttcatagggg ttaagctaaa    180

aaagcgaggc gaggagcccc tctccaatgg ctcagttttg ctgaataatc acgtgtgaat    240

cgaggggcgg gcttttggca ggcagatctt actagtattt actaccaagc tctactccag    300

attaaccatc ccagtccttc tgtcagtctc cgatgccatc atgcagcctg gttaggagca    360

aaggaaaggg gaaaaagaaa aacgactaat tcatcttttc ctgatcgtca ggaccctaaa    420

gaatggccga gccttggggg aacgagttgg cgtccgcagc tgccaggggg gacctagagc    480

aacttactag tttgttgcaa aataatgtaa acgtcaatgc acaaaatgga tttggaagga    540

ctgcgctgca ggttatgaaa cttggaaatc ccgagattgc caggagactg ctacttagag    600

gtgctaatcc cgatttgaaa gaccgaactg gtttcgctgt cattcatgat gcggccagag    660

caggtttcct ggacacttta cagactttgc tggagtttca agctgatgtt aacatcgagg    720

ataatgaagg gaacctgccc ttgcacttgg ctgccaaaga aggccacctc cgggtggtgg    780

agttcctggt gaagcacacg gccagcaatg tggggcatcg gaaccataag ggggacaccg    840

cctgtgattt ggccaggctc tatgggagga atgaggttgt tagcctgatg caggcaaacg    900

gggctggggg agccacaaat cttcaataaa cgtggggagg gctcccccac gttgcctcta    960

ctttatcaat taactgagta gctctcctga cttttaatgt catttgttaa aatacagttc   1020

tgtcatatgt taagcagcta aattttctga aactgcataa gtgaaaatct tacaacaggc   1080

ttatgaatat atttaagcaa catcttttta acctgcaaaa tctgttctaa catgtaattg   1140

cagataactt tgactttctt ctgaatattt tatctttcct tggcttttcc cttgcttccc   1200

cttttgccaa tctcaacacc caagttgaag actttgtttt taaaatggtt tgtcctgatg   1260

cttttgtcta attaaaacac tttcaaaaca ggac                               1294


<210>  6246
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  6246

Met Ala Glu Pro Trp Gly Asn Glu Leu Ala Ser Ala Ala Ala Arg Gly 
1               5                   10                  15      


Asp Leu Glu Gln Leu Thr Ser Leu Leu Gln Asn Asn Val Asn Val Asn 
            20                  25                  30          


Ala Gln Asn Gly Phe Gly Arg Thr Ala Leu Gln Val Met Lys Leu Gly 
        35                  40                  45              


Asn Pro Glu Ile Ala Arg Arg Leu Leu Leu Arg Gly Ala Asn Pro Asp 
    50                  55                  60                  


Leu Lys Asp Arg Thr Gly Phe Ala Val Ile His Asp Ala Ala Arg Ala 
65                  70                  75                  80  


Gly Phe Leu Asp Thr Leu Gln Thr Leu Leu Glu Phe Gln Ala Asp Val 
                85                  90                  95      


Asn Ile Glu Asp Asn Glu Gly Asn Leu Pro Leu His Leu Ala Ala Lys 
            100                 105                 110         


Glu Gly His Leu Arg Val Val Glu Phe Leu Val Lys His Thr Ala Ser 
        115                 120                 125             


Asn Val Gly His Arg Asn His Lys Gly Asp Thr Ala Cys Asp Leu Ala 
    130                 135                 140                 


Arg Leu Tyr Gly Arg Asn Glu Val Val Ser Leu Met Gln Ala Asn Gly 
145                 150                 155                 160 


Ala Gly Gly Ala Thr Asn Leu Gln 
                165             


<210>  6247
<211>  1530
<212>  DNA
<213>  Homosapiens

<400>  6247
attttctgcc ccgatctata gtcccttgag tctccacaca cactcctcac agagatctgt     60

agcgtaggta cgtgacagct ctgcctacat ctgacgtccg gagtcattaa ccaggaatgt    120

atgtgtgtct gtgtgtctct ctgtggagtc gtcagaattc ttcatagggg ttaagctaaa    180

aaagcgaggc gaggagcccc tctccaatgg ctcagttttg ctgaataatc acgtgtgaat    240

cgaggggcgg gcttttggca ggcagatctt actagtattt actaccaagc tctactccag    300

attaaccatc ccagtccttc tgtcagtctc cgatgccatc atgcagcctg gttaggagca    360

aaggaaaggg gaaaaagaaa aacgactaat tcatcttttc ctgatcgtca ggaccctaaa    420

gaatggccga gccttggggg aacgagttgg cgtccgcagc tgccaggggg gacctagagc    480

aacttactag tttgttgcaa aataatgtaa acgtcaatgc acaaaatgga tttggaagga    540

ctgcgctgca ggttatgaaa cttggaaatc ccgagattgc caggagactg ctacttagag    600

gtgctaatcc cgatttgaaa gaccgaactg gtttcgctgt cattcatgat gcggccagag    660

caggtttcct ggacacttta cagactttgc tggagtttca agctgatgtt aacatcgagg    720

ataatgaagg gaacctgccc ttgcacttgg ctgccaaaga aggccacctc cgggtggtgg    780

agttcctggt gaagcacacg gccagcaatg tggggcatcg gaaccataag ggggacaccg    840

cctgtgattt ggccaggctc tatgggagga atgaggttgt tagcctgatg caggcaaacg    900

gggctggggg agccacaaat cttcaataaa cgtggggagg gctcccccac gttgcctcta    960

ctttatcaat taactgagta gctctcctga cttttaatgt catttgttaa aatacagttc   1020

tgtcatatgt taagcagcta aattttctga aactgcataa gtgaaaatct tacaacaggc   1080

ttatgaatat atttaagcaa catcttttta acctgcaaaa tctgttctaa catgtaattg   1140

cagataactt tgactttctt ctgaatattt tatctttcct tggcttttcc cttgcttccc   1200

cttttgccaa tctcaacacc caagttgaag actttgtttt taaaatggtt tgtcctgatg   1260

cttttgtcta attaaaacac tttcaaaaca ggacaacatt tttctgtgat tttccctcct   1320

ttagaaccca tacacaactt atcacttgct aaggagaact gtactaaaag ttattgaatg   1380

tcttaagtct ttacactaga aaaggtagac caactggaaa actagacata ctctcttgat   1440

gattcagttg ttttcatcct ttacccatgt cccgtccacc ttggtgccta gtatttctgc   1500

tttaaaacaa aataaggaca actttttttt                                    1530


<210>  6248
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  6248

Met Ala Glu Pro Trp Gly Asn Glu Leu Ala Ser Ala Ala Ala Arg Gly 
1               5                   10                  15      


Asp Leu Glu Gln Leu Thr Ser Leu Leu Gln Asn Asn Val Asn Val Asn 
            20                  25                  30          


Ala Gln Asn Gly Phe Gly Arg Thr Ala Leu Gln Val Met Lys Leu Gly 
        35                  40                  45              


Asn Pro Glu Ile Ala Arg Arg Leu Leu Leu Arg Gly Ala Asn Pro Asp 
    50                  55                  60                  


Leu Lys Asp Arg Thr Gly Phe Ala Val Ile His Asp Ala Ala Arg Ala 
65                  70                  75                  80  


Gly Phe Leu Asp Thr Leu Gln Thr Leu Leu Glu Phe Gln Ala Asp Val 
                85                  90                  95      


Asn Ile Glu Asp Asn Glu Gly Asn Leu Pro Leu His Leu Ala Ala Lys 
            100                 105                 110         


Glu Gly His Leu Arg Val Val Glu Phe Leu Val Lys His Thr Ala Ser 
        115                 120                 125             


Asn Val Gly His Arg Asn His Lys Gly Asp Thr Ala Cys Asp Leu Ala 
    130                 135                 140                 


Arg Leu Tyr Gly Arg Asn Glu Val Val Ser Leu Met Gln Ala Asn Gly 
145                 150                 155                 160 


Ala Gly Gly Ala Thr Asn Leu Gln 
                165             


<210>  6249
<211>  682
<212>  DNA
<213>  Homosapiens

<400>  6249
agtcatatgg cttcacctaa aggttttttt aattacttga cctattttct tgctgctggt     60

gctgtcactt tgggaattgg tttctttgct ttggcatcag ctttgtggtt cctgatttgc    120

aaacgaagag aaatatttca aaattccaaa tttaaagcaa ttgatgagag atgcaggcaa    180

agaccatcaa tggcgaagat taaatctcat tctcagtgtg tttttatttc tcgaaatttt    240

catactggga gattccaatt acaggaggag caaagaaaaa aggaagcagc acatataaaa    300

gcaattaaag atcattctaa agatgaaccc caacttgcaa caaaaaatat catttgtgat    360

ccctcagaga ccagctccac aacaaatcgc agcagtgtta cattaagctt atcaacatta    420

ccatctgatt cttattacag ccaaagtata gaagcagctg atgactggtt ttctgatgat    480

tctctagtga aaaggaactc tccaatgcct tctctcgggg aacctctaat ggaaaaagta    540

ttttcatacc tgtcaaccat ttcattagaa gagggtactg aaagtgtact gaatgacact    600

ttatgaccat caaaaagatg actacattaa gggaaaatgt tcatgaagaa acacagaggt    660

tgaaatataa aaccttcaac at                                             682


<210>  6250
<211>  199
<212>  PRT
<213>  Homosapiens

<400>  6250

Met Ala Ser Pro Lys Gly Phe Phe Asn Tyr Leu Thr Tyr Phe Leu Ala 
1               5                   10                  15      


Ala Gly Ala Val Thr Leu Gly Ile Gly Phe Phe Ala Leu Ala Ser Ala 
            20                  25                  30          


Leu Trp Phe Leu Ile Cys Lys Arg Arg Glu Ile Phe Gln Asn Ser Lys 
        35                  40                  45              


Phe Lys Ala Ile Asp Glu Arg Cys Arg Gln Arg Pro Ser Met Ala Lys 
    50                  55                  60                  


Ile Lys Ser His Ser Gln Cys Val Phe Ile Ser Arg Asn Phe His Thr 
65                  70                  75                  80  


Gly Arg Phe Gln Leu Gln Glu Glu Gln Arg Lys Lys Glu Ala Ala His 
                85                  90                  95      


Ile Lys Ala Ile Lys Asp His Ser Lys Asp Glu Pro Gln Leu Ala Thr 
            100                 105                 110         


Lys Asn Ile Ile Cys Asp Pro Ser Glu Thr Ser Ser Thr Thr Asn Arg 
        115                 120                 125             


Ser Ser Val Thr Leu Ser Leu Ser Thr Leu Pro Ser Asp Ser Tyr Tyr 
    130                 135                 140                 


Ser Gln Ser Ile Glu Ala Ala Asp Asp Trp Phe Ser Asp Asp Ser Leu 
145                 150                 155                 160 


Val Lys Arg Asn Ser Pro Met Pro Ser Leu Gly Glu Pro Leu Met Glu 
                165                 170                 175     


Lys Val Phe Ser Tyr Leu Ser Thr Ile Ser Leu Glu Glu Gly Thr Glu 
            180                 185                 190         


Ser Val Leu Asn Asp Thr Leu 
        195                 


<210>  6251
<211>  915
<212>  DNA
<213>  Homosapiens

<400>  6251
agtcatatgg cttcacctaa aggttttttt aattacttga cctattttct tgctgctggt     60

gctgtcactt tgggaattgg tttctttgct ttggcatcag ctttgtggtt cctgatttgc    120

aaacgaagag aaatatttca aaattccaaa tttaaagcaa ttgatgagag atgcaggcaa    180

agaccatcaa tggcgaagat taaatctcat tctcagtgtg tttttatttc tcgaaatttt    240

catactggga gattccaatt acaggaggag caaagaaaaa aggaagcagc acatataaaa    300

gcaattaaag atcattctaa agatgaaccc caacttgcaa caaaaaatat catttgtgat    360

ccctcagaga ccagctccac aacaaatcgc agcagtgtta cattaagctt atcaacatta    420

ccatctgatt cttattacag ccaaagtata gaagcagctg atgactggtt ttctgatgat    480

tctctagtga aaaggaactc tccaatgcct tctctcgggg aacctctaat ggaaaaagta    540

ttttcatacc tgtcaaccat ttcattagaa gagggtactg aaagtgtact gaatgacact    600

ttatgaccat caaaaagatg actacattaa gggaaaatgt tcatgaagaa acacagaggt    660

tgaaatataa aaccttcaac ataatactga atgacttttt tcttttgaaa ccttgtatac    720

aatcagcttc tgagtctctt aacatgtcca tgctaatatt gctttttttg ttctttacca    780

tagagcggct ctacttccct tgctggttct tatttctaga aacaaaatta ggaagaacta    840

gagtgatgtc atgaacatta agcttaactt attgtatctc atccaaagac atattaaata    900

aaatgagtgt atgtc                                                     915


<210>  6252
<211>  199
<212>  PRT
<213>  Homosapiens

<400>  6252

Met Ala Ser Pro Lys Gly Phe Phe Asn Tyr Leu Thr Tyr Phe Leu Ala 
1               5                   10                  15      


Ala Gly Ala Val Thr Leu Gly Ile Gly Phe Phe Ala Leu Ala Ser Ala 
            20                  25                  30          


Leu Trp Phe Leu Ile Cys Lys Arg Arg Glu Ile Phe Gln Asn Ser Lys 
        35                  40                  45              


Phe Lys Ala Ile Asp Glu Arg Cys Arg Gln Arg Pro Ser Met Ala Lys 
    50                  55                  60                  


Ile Lys Ser His Ser Gln Cys Val Phe Ile Ser Arg Asn Phe His Thr 
65                  70                  75                  80  


Gly Arg Phe Gln Leu Gln Glu Glu Gln Arg Lys Lys Glu Ala Ala His 
                85                  90                  95      


Ile Lys Ala Ile Lys Asp His Ser Lys Asp Glu Pro Gln Leu Ala Thr 
            100                 105                 110         


Lys Asn Ile Ile Cys Asp Pro Ser Glu Thr Ser Ser Thr Thr Asn Arg 
        115                 120                 125             


Ser Ser Val Thr Leu Ser Leu Ser Thr Leu Pro Ser Asp Ser Tyr Tyr 
    130                 135                 140                 


Ser Gln Ser Ile Glu Ala Ala Asp Asp Trp Phe Ser Asp Asp Ser Leu 
145                 150                 155                 160 


Val Lys Arg Asn Ser Pro Met Pro Ser Leu Gly Glu Pro Leu Met Glu 
                165                 170                 175     


Lys Val Phe Ser Tyr Leu Ser Thr Ile Ser Leu Glu Glu Gly Thr Glu 
            180                 185                 190         


Ser Val Leu Asn Asp Thr Leu 
        195                 


<210>  6253
<211>  509
<212>  DNA
<213>  Homosapiens

<400>  6253
ctgggaagaa gaggaaaata tatttagacg aacaaccaga aatctatttc tattctctgg     60

aagagcttgt ataagataag aaatacttga atcatgggtt tttttaatta cttgacctat    120

tttcttgctg ctggtgctgt cactttggga attggtttct ttgctttggc atcagctttg    180

tggttcctga tttgcaaacg aagagaaata tttcaaaatt ccaaatttaa agcaattgat    240

gagagatgca ggcaaagacc atcaatggcg aagattaaat ctcattctca gtgtgttttt    300

atttctcgaa attttcatac tgggagattc caattacagt tttgaaggct gagaagtcca    360

agatcaagat gctgaaagat ccggttctgg tgaaggccct cttcctgatt tggagatggc    420

ctttttcttg ctgtgttttc agatggcagg gagcagagag agcaagagcg cactttcaca    480

tctcttctta taaaggcact aattccatt                                      509


<210>  6254
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  6254

Met Gly Phe Phe Asn Tyr Leu Thr Tyr Phe Leu Ala Ala Gly Ala Val 
1               5                   10                  15      


Thr Leu Gly Ile Gly Phe Phe Ala Leu Ala Ser Ala Leu Trp Phe Leu 
            20                  25                  30          


Ile Cys Lys Arg Arg Glu Ile Phe Gln Asn Ser Lys Phe Lys Ala Ile 
        35                  40                  45              


Asp Glu Arg Cys Arg Gln Arg Pro Ser Met Ala Lys Ile Lys Ser His 
    50                  55                  60                  


Ser Gln Cys Val Phe Ile Ser Arg Asn Phe His Thr Gly Arg Phe Gln 
65                  70                  75                  80  


Leu Gln Phe 
            


<210>  6255
<211>  2366
<212>  DNA
<213>  Homosapiens

<400>  6255
tcattcacca tttactgaag ttgtgtgtgc gtgtgtatac cagaccccac gctaaggact     60

ggggaaaagg atgatcatac ctggcttgtt cctgatagag cccagagacc acctgggaag    120

acaagtaatc aggtccagct tcggtgtgag gccctcaatc cagaacatca tggctctgac    180

tcaccagcct tcagctgctg cactctgctc tcctcagtgg ctgccttgca cctggaactc    240

aatttttttt tatttttatt tttttgagat ggagtcttgc tctgtaaccc aggctggagt    300

gcaatggcgc aatctcggct cactgcaact tccacctccc gggttcaagt gcttctcctg    360

cctcagcctc ctgagctggg attacagttg tccaccacca tgcccagcta atttttgtgt    420

gttttttttt tagtagagac agggtttcac catgttggcc agactggtct tgaactcctg    480

acctcaggtg atccgcctgc cttggcctcc caaagtgctg ggattacagg cataagccac    540

cacacccagc caatttttta attttttaaa ttttttgtag agacagggtc ttgctatgtt    600

gcccaggctg atcctcaaac tcctggcatc aagagacact cctgactcca cctcctaaat    660

gctgggatta gagatgtgag ccattgttcc tggcccctat tgaatttttt agtccactgt    720

tgagacctat tgatcagaaa aaaggttgct ttcaaaaggt tattactaaa aaaaaaaaaa    780

aagaagaaga agaagaaaga aaaaagatta caaagattac tgctcatact cattcacaat    840

gcatttagtc acccaagagc tctaatggag atgtacaagg agatgaatgt tgttttcatg    900

cctgctaata cacatccttt ctgcagccca tggatcaagg agtaatttaa acctgcaagt    960

cttattattt aaaattacat ttcataaggc tatagctgcc atagatagtg attctgctga   1020

tggatttggg caaagtacat tgaaaacctt ctggaaagga ttcaccattc tagatgccat   1080

taagaatatt tgtggttcca gggaggaagc caaaaaccaa catttacagg agtttggaag   1140

aaagtgactc tataactcat ggatgacttt cagaggggct caagacttca ctagaggaag   1200

taactgcagg tatgatagaa gtagcaaggg aactagaatt agaaatggaa cctgaagatg   1260

tgactgaatt gctgcaatct catgataaaa tttaaatgga tgcagagttg tttcttatgg   1320

atgagcaaat aagtgatttc ttcttctttt cttttttttt ttttgaggtg gagtctcgct   1380

ctgtcaccca ggcttgagtg cagtgatgtg atctctgctc actgcaacct taacctccca   1440

agctcaagcg attctcctgc ctcagcctcc caagtagctg ggattacagg tgtccaccac   1500

catgactggc taatttttgt atttttagtg gagacagggt ttcaccatgc tgaccaggct   1560

ggtctcggac tcctgacctc aagtgatcct cctggcttga cctcccaaag tgctgggatt   1620

acaggtgtga gccaccatgc ccagcctctt tttttttttt tttttaaata gagacagagt   1680

ctcactgtgt tgcccaggct ggcaatcatg gctcactgca accttgacct cctagactca   1740

agccatcctc ctggttcaac cttccaagta actagtacta catgtgtgca ccaccctgct   1800

cagctaatta aaaataattt ttgtgaggag atgggggtct cactatgttg ccaaggctgg   1860

tttagaatgc ccaagctcac gtgattctct cactctggac tcccaaagtt ctgggattac   1920

aggtgtgtgc catcgtgcct agccagaaag tggtttcttg agatggaatc tactcctgat   1980

gaagatactg tgaaatgtag aatggtagaa atgacaacaa aggatttaga atatgacata   2040

aacttagttg ataaagcagc agcagggttt gagaggactg agtccaattt tggaagatat   2100

tctactatga gtaaaatgct atcaaatagt actgcatact acagataaat ctttcatgaa   2160

aggaagtgtc aattcatgcg gcaaatgcta cattgtctta ttttaagaaa ttgtcacagc   2220

tggcatggtg gcacacacct gtaatcccag ctacttggga ggctgaggca ggagaatcgc   2280

ttgaacccag gaggcggagg ttgcagtgag acgagatcgt gtcattgtac tccagcctgg   2340

gcaacaagag ggagactcgg tctcag                                        2366


<210>  6256
<211>  120
<212>  PRT
<213>  Homosapiens

<400>  6256

Met Ile Ile Pro Gly Leu Phe Leu Ile Glu Pro Arg Asp His Leu Gly 
1               5                   10                  15      


Arg Gln Val Ile Arg Ser Ser Phe Gly Val Arg Pro Ser Ile Gln Asn 
            20                  25                  30          


Ile Met Ala Leu Thr His Gln Pro Ser Ala Ala Ala Leu Cys Ser Pro 
        35                  40                  45              


Gln Trp Leu Pro Cys Thr Trp Asn Ser Ile Phe Phe Tyr Phe Tyr Phe 
    50                  55                  60                  


Phe Glu Met Glu Ser Cys Ser Val Thr Gln Ala Gly Val Gln Trp Arg 
65                  70                  75                  80  


Asn Leu Gly Ser Leu Gln Leu Pro Pro Pro Gly Phe Lys Cys Phe Ser 
                85                  90                  95      


Cys Leu Ser Leu Leu Ser Trp Asp Tyr Ser Cys Pro Pro Pro Cys Pro 
            100                 105                 110         


Ala Asn Phe Cys Val Phe Phe Phe 
        115                 120 


<210>  6257
<211>  2547
<212>  DNA
<213>  Homosapiens

<400>  6257
ggctgccgcc gtctcgctga ggcggagtag gatgaggccc gcggccgtgg ctccggcgtc     60

ggcgggggca gcagcagctg aggcagcagc tgaggcagcc gcgacggccg cgcccccccc    120

cgctgacctg gattaggccc agcagctccg tggccgccgc cgccccgcgg gggggcgggg    180

tggggaagtg cttcgtctcc ccgccccccc ccccccatcg ctgcctcgca ggaggcgaac    240

gccgcgaccc cagcggagcc cgcggcccag ccttgatccc ccaaccccgg gggctggcat    300

gagcggcccc tcggcggcac cgtggggcgg tggagtcgcc tccgcctgat ccccggcctg    360

tcgcccgacc ccacctcgcc aaccgaggcg gaccgcggag tgtgcgaacg accccaccgc    420

tgctttctcc tcccccagat cacgcacccc agctccggaa gatggggaac tgcctcaaat    480

cccccacctc ggatgacatc tccctgcttc acgagtctca gtccgaccgg gctagctttg    540

gcgaggggac ggagccggat caggagccgc cgccgccata tcaggtgtgt gatctgtatg    600

atggactttg tttatgggga cccaattcga tttctgccgt gcatgcacat ctatcacctg    660

gactgtatag atgactggtt gatgagatcc ttcacgtgcc cctcctgcat ggagccagtt    720

gatgcagcac tgctttcatc ctatgagact aattgagcca gggtctctta tctgacttca    780

agtgaaccac cattttggtg gttttgatct tttgtcactg agcccaaaga gccagggatt    840

aggaattaag atcgtgcaca aaagtttcct taaaattcct ggatggctgc agatgttggg    900

ggaaaaagta cgtgatattt tagaaactta gtgggaaaag taggatggta tttttatgta    960

aagccttgac ccaatgttta aaaatataat tgtatttaga tcttgttatt gctccagtac   1020

ataggaattg tgtaaagtgt taacagcagc tgtatttgtt taaattgtgt gtattgaaga   1080

ttaggaaaaa gatagtagtt atttttccta aatgaaataa ctttcttctc ttccccttcc   1140

ccacccgaat tcttttctga agttgctggc atttgggtca aggttttatt aaaagctaca   1200

ttttataaca ctggcacaca caaaaaagta gttttaagct tgtttgcaca gttctttttt   1260

tccattggaa atggaattca ttgccttagg tctttttaaa tagtgtatta ttatcgttgg   1320

ggctggctct atgcttgaaa accagtttat ttataacctg ttataagtgc tatattctgt   1380

ttgcagttag gaaatgcaga attcaaagtg atctcctagc ttgtaagcaa actgagatgc   1440

actatccctt ttctataaaa aataagttaa tgtgtcaaga aaccaactct attaaggtgg   1500

ggtttaatat taccctttcc tatgtgtttt atctaattat tttggttgtt aatatggtga   1560

taatggaaag tcaagttaaa ttttaaatat taagaattct gatttattga gattgaatta   1620

tgccaccacg tttatgtaaa aatgaaggtg gcaccgtggt gagacctaat gagaaatagt   1680

tactcagttg taaaaatttt gatttattct ctttcttctg acctccttgc ctcttgtctt   1740

gaaccatagc aaaaggatac tgcatctctc attactgtag tgctgaggtt attgaagtta   1800

tacaaaacac atctcagtct ctgtttcttg gaaaggtatc tattacatcc tgctagctga   1860

ctgacaaaac taagcaggga gaataaagat aattgtattt tatgttttgc acacaaacgc   1920

agaatttgta taaccatatg acttcatagt tgtgatctca aaaaagaagg aatttctcct   1980

ttgtttcttg cagttaatgt aagaatactt taaatctcta agcttctgaa gtgttagagg   2040

tagagatggt ctagtaaaga tgtagtagta atgttttatc catttagcat gtgtttattt   2100

tttcatatgt actcaaaggt gacttattgg ttcacctcag tgatattaca gctaaaaaaa   2160

tcattcatta gcaaaaggaa aagtggtctc aacctaacat cagaagtgtt tcttattatt   2220

attttatatt gagttgaata ttgaactcta acagttttct acatacaaaa cacagtgtca   2280

tgaaggttat tcataattgc attatagagg aatgtagtat gtcataagta ctttgtaaag   2340

atttgacatt caactgtagt atccatatgt tgcttaaatt tccttatgag ccccatgatg   2400

gaaagactta aagatgaatt tgagaaaaat tgaaagaaat tagattatca ggttctgtta   2460

aattgttaca tgtatcttgc ttaaatttct gtttattaat ttatatccac ccaagtacat   2520

aaagcaaatt tggaggaaac aactgaa                                       2547


<210>  6258
<211>  87
<212>  PRT
<213>  Homosapiens

<400>  6258

Met Thr Ser Pro Cys Phe Thr Ser Leu Ser Pro Thr Gly Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Arg Ser Arg Ile Arg Ser Arg Arg Arg His Ile Arg Cys 
            20                  25                  30          


Val Ile Cys Met Met Asp Phe Val Tyr Gly Asp Pro Ile Arg Phe Leu 
        35                  40                  45              


Pro Cys Met His Ile Tyr His Leu Asp Cys Ile Asp Asp Trp Leu Met 
    50                  55                  60                  


Arg Ser Phe Thr Cys Pro Ser Cys Met Glu Pro Val Asp Ala Ala Leu 
65                  70                  75                  80  


Leu Ser Ser Tyr Glu Thr Asn 
                85          


<210>  6259
<211>  2724
<212>  DNA
<213>  Homosapiens

<400>  6259
ggctgccgcc gtctcgctga ggcggagtag gatgaggccc gcggccgtgg ctccggcgtc     60

ggcgggggca gcagcagctg aggcagcagc tgaggcagcc gcgacggccg cgcccccccc    120

cgctgacctg gattaggccc agcagctccg tggccgccgc cgccccgcgg gggggcgggg    180

tggggaagtg cttcgtctcc ccgccccccc ccccccatcg ctgcctcgca ggaggcgaac    240

gccgcgaccc cagcggagcc cgcggcccag ccttgatccc ccaaccccgg gggctggcat    300

gagcggcccc tcggcggcac cgtggggcgg tggagtcgcc tccgcctgat ccccggcctg    360

tcgcccgacc ccacctcgcc aaccgaggcg gaccgcggag tgtgcgaacg accccaccgc    420

tgctttctcc tcccccagat cacgcacccc agctccggaa gatggggaac tgcctcaaat    480

cccccacctc ggatgacatc tccctgcttc acgagtctca gtccgaccgg gctagctttg    540

gcgaggggac ggagccggat caggagccgc cgccgccata tcaggaacaa gttccagttc    600

cagtctacca cccaacacct agccagactc ggctagcaac tcagctgact gaagaggaac    660

aaattaggat agctcaaaga ataggtctta tacaacatct gcctaaagga gtttatgacc    720

ctggaagaga tggatcagaa aaaaagatcc gggagtgtgt gatctgtatg atggactttg    780

tttatgggga cccaattcga tttctgccgt gcatgcacat ctatcacctg gactgtatag    840

atgactggtt gatgagatcc ttcacgtgcc cctcctgcat ggagccagtt gatgcagcac    900

tgctttcatc ctatgagact aattgagcca gggtctctta tctgacttca agtgaaccac    960

cattttggtg gttttgatct tttgtcactg agcccaaaga gccagggatt aggaattaag   1020

atcgtgcaca aaagtttcct taaaattcct ggatggctgc agatgttggg ggaaaaagta   1080

cgtgatattt tagaaactta gtgggaaaag taggatggta tttttatgta aagccttgac   1140

ccaatgttta aaaatataat tgtatttaga tcttgttatt gctccagtac ataggaattg   1200

tgtaaagtgt taacagcagc tgtatttgtt taaattgtgt gtattgaaga ttaggaaaaa   1260

gatagtagtt atttttccta aatgaaataa ctttcttctc ttccccttcc ccacccgaat   1320

tcttttctga agttgctggc atttgggtca aggttttatt aaaagctaca ttttataaca   1380

ctggcacaca caaaaaagta gttttaagct tgtttgcaca gttctttttt tccattggaa   1440

atggaattca ttgccttagg tctttttaaa tagtgtatta ttatcgttgg ggctggctct   1500

atgcttgaaa accagtttat ttataacctg ttataagtgc tatattctgt ttgcagttag   1560

gaaatgcaga attcaaagtg atctcctagc ttgtaagcaa actgagatgc actatccctt   1620

ttctataaaa aataagttaa tgtgtcaaga aaccaactct attaaggtgg ggtttaatat   1680

taccctttcc tatgtgtttt atctaattat tttggttgtt aatatggtga taatggaaag   1740

tcaagttaaa ttttaaatat taagaattct gatttattga gattgaatta tgccaccacg   1800

tttatgtaaa aatgaaggtg gcaccgtggt gagacctaat gagaaatagt tactcagttg   1860

taaaaatttt gatttattct ctttcttctg acctccttgc ctcttgtctt gaaccatagc   1920

aaaaggatac tgcatctctc attactgtag tgctgaggtt attgaagtta tacaaaacac   1980

atctcagtct ctgtttcttg gaaaggtatc tattacatcc tgctagctga ctgacaaaac   2040

taagcaggga gaataaagat aattgtattt tatgttttgc acacaaacgc agaatttgta   2100

taaccatatg acttcatagt tgtgatctca aaaaagaagg aatttctcct ttgtttcttg   2160

cagttaatgt aagaatactt taaatctcta agcttctgaa gtgttagagg tagagatggt   2220

ctagtaaaga tgtagtagta atgttttatc catttagcat gtgtttattt tttcatatgt   2280

actcaaaggt gacttattgg ttcacctcag tgatattaca gctaaaaaaa tcattcatta   2340

gcaaaaggaa aagtggtctc aacctaacat cagaagtgtt tcttattatt attttatatt   2400

gagttgaata ttgaactcta acagttttct acatacaaaa cacagtgtca tgaaggttat   2460

tcataattgc attatagagg aatgtagtat gtcataagta ctttgtaaag atttgacatt   2520

caactgtagt atccatatgt tgcttaaatt tccttatgag ccccatgatg gaaagactta   2580

aagatgaatt tgagaaaaat tgaaagaaat tagattatca ggttctgtta aattgttaca   2640

tgtatcttgc ttaaatttct gtttattaat ttatatccac ccaagtacat aaagcaaatt   2700

tggaggaaac aactgaagtt gtgc                                          2724


<210>  6260
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  6260

Met Gly Asn Cys Leu Lys Ser Pro Thr Ser Asp Asp Ile Ser Leu Leu 
1               5                   10                  15      


His Glu Ser Gln Ser Asp Arg Ala Ser Phe Gly Glu Gly Thr Glu Pro 
            20                  25                  30          


Asp Gln Glu Pro Pro Pro Pro Tyr Gln Glu Gln Val Pro Val Pro Val 
        35                  40                  45              


Tyr His Pro Thr Pro Ser Gln Thr Arg Leu Ala Thr Gln Leu Thr Glu 
    50                  55                  60                  


Glu Glu Gln Ile Arg Ile Ala Gln Arg Ile Gly Leu Ile Gln His Leu 
65                  70                  75                  80  


Pro Lys Gly Val Tyr Asp Pro Gly Arg Asp Gly Ser Glu Lys Lys Ile 
                85                  90                  95      


Arg Glu Cys Val Ile Cys Met Met Asp Phe Val Tyr Gly Asp Pro Ile 
            100                 105                 110         


Arg Phe Leu Pro Cys Met His Ile Tyr His Leu Asp Cys Ile Asp Asp 
        115                 120                 125             


Trp Leu Met Arg Ser Phe Thr Cys Pro Ser Cys Met Glu Pro Val Asp 
    130                 135                 140                 


Ala Ala Leu Leu Ser Ser Tyr Glu Thr Asn 
145                 150                 


<210>  6261
<211>  2689
<212>  DNA
<213>  Homosapiens

<400>  6261
ggctgccgcc gtctcgctga ggcggagtag gatgaggccc gcggccgtgg ctccggcgtc     60

ggcgggggca gcagcagctg aggcagcagc tgaggcagcc gcgacggccg cgcccccccc    120

cgctgacctg gattaggccc agcagctccg tggccgccgc cgccccgcgg gggggcgggg    180

tggggaagtg cttcgtctcc ccgccccccc ccccccatcg ctgcctcgca ggaggcgaac    240

gccgcgaccc cagcggagcc cgcggcccag ccttgatccc ccaaccccgg gggctggcat    300

gagcggcccc tcggcggcac cgtggggcgg tggagtcgcc tccgcctgat ccccggcctg    360

tcgcccgacc ccacctcgcc aaccgaggcg gaccgcggag tgtgcgaacg accccaccgc    420

tgctttctcc tcccccagat cacgcacccc agctccggaa gatggggaac tgcctcaaat    480

cccccacctc ggatgacatc tccctgcttc acgagtctca gtccgaccgg gctagctttg    540

gcgaggggac ggagccggat caggagccgc cgccgccata tcaggtgtgt gatctgtatg    600

atggactttg tttatgggga cccaattcga tttctgccgt gcatgcacat ctatcacctg    660

gactgtatag atgactggtt gatgagatcc ttcacgtgcc cctcctgcat ggagccagtt    720

gatgcagcac tgctttcatc ctatgagact aattgagcca gggtctctta tctgacttca    780

agtgaaccac cattttggtg gttttgatct tttgtcactg agcccaaaga gccagggatt    840

aggaattaag atcgtgcaca aaagtttcct taaaattcct ggatggctgc agatgttggg    900

ggaaaaagta cgtgatattt tagaaactta gtgggaaaag taggatggta tttttatgta    960

aagccttgac ccaatgttta aaaatataat tgtatttaga tcttgttatt gctccagtac   1020

ataggaattg tgtaaagtgt taacagcagc tgtatttgtt taaattgtgt gtattgaaga   1080

ttaggaaaaa gatagtagtt atttttccta aatgaaataa ctttcttctc ttccccttcc   1140

ccacccgaat tcttttctga agttgctggc atttgggtca aggttttatt aaaagctaca   1200

ttttataaca ctggcacaca caaaaaagta gttttaagct tgtttgcaca gttctttttt   1260

tccattggaa atggaattca ttgccttagg tctttttaaa tagtgtatta ttatcgttgg   1320

ggctggctct atgcttgaaa accagtttat ttataacctg ttataagtgc tatattctgt   1380

ttgcagttag gaaatgcaga attcaaagtg atctcctagc ttgtaagcaa actgagatgc   1440

actatccctt ttctataaaa aataagttaa tgtgtcaaga aaccaactct attaaggtgg   1500

ggtttaatat taccctttcc tatgtgtttt atctaattat tttggttgtt aatatggtga   1560

taatggaaag tcaagttaaa ttttaaatat taagaattct gatttattga gattgaatta   1620

tgccaccacg tttatgtaaa aatgaaggtg gcaccgtggt gagacctaat gagaaatagt   1680

tactcagttg taaaaatttt gatttattct ctttcttctg acctccttgc ctcttgtctt   1740

gaaccatagc aaaaggatac tgcatctctc attactgtag tgctgaggtt attgaagtta   1800

tacaaaacac atctcagtct ctgtttcttg gaaaggtatc tattacatcc tgctagctga   1860

ctgacaaaac taagcaggga gaataaagat aattgtattt tatgttttgc acacaaacgc   1920

agaatttgta taaccatatg acttcatagt tgtgatctca aaaaagaagg aatttctcct   1980

ttgtttcttg cagttaatgt aagaatactt taaatctcta agcttctgaa gtgttagagg   2040

tagagatggt ctagtaaaga tgtagtagta atgttttatc catttagcat gtgtttattt   2100

tttcatatgt actcaaaggt gacttattgg ttcacctcag tgatattaca gctaaaaaaa   2160

tcattcatta gcaaaaggaa aagtggtctc aacctaacat cagaagtgtt tcttattatt   2220

attttatatt gagttgaata ttgaactcta acagttttct acatacaaaa cacagtgtca   2280

tgaaggttat tcataattgc attatagagg aatgtagtat gtcataagta ctttgtaaag   2340

atttgacatt caactgtagt atccatatgt tgcttaaatt tccttatgag ccccatgatg   2400

gaaagactta aagatgaatt tgagaaaaat tgaaagaaat tagattatca ggttctgtta   2460

aattgttaca tgtatcttgc ttaaatttct gtttattaat ttatatccac ccaagtacat   2520

aaagcaaatt tggaggaaac aactgaagtt gtgcaatatt ttctgataat tgcttttttt   2580

attcttgtgt tttctactta aacataatgt ctgtgtcatc aagtattata gtcagacttt   2640

tctttttttc tagattgtta aaattggcaa atgaactttt ttaaaaatc               2689


<210>  6262
<211>  87
<212>  PRT
<213>  Homosapiens

<400>  6262

Met Thr Ser Pro Cys Phe Thr Ser Leu Ser Pro Thr Gly Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Arg Ser Arg Ile Arg Ser Arg Arg Arg His Ile Arg Cys 
            20                  25                  30          


Val Ile Cys Met Met Asp Phe Val Tyr Gly Asp Pro Ile Arg Phe Leu 
        35                  40                  45              


Pro Cys Met His Ile Tyr His Leu Asp Cys Ile Asp Asp Trp Leu Met 
    50                  55                  60                  


Arg Ser Phe Thr Cys Pro Ser Cys Met Glu Pro Val Asp Ala Ala Leu 
65                  70                  75                  80  


Leu Ser Ser Tyr Glu Thr Asn 
                85          


<210>  6263
<211>  2885
<212>  DNA
<213>  Homosapiens

<400>  6263
ggctgccgcc gtctcgctga ggcggagtag gatgaggccc gcggccgtgg ctccggcgtc     60

ggcgggggca gcagcagctg aggcagcagc tgaggcagcc gcgacggccg cgcccccccc    120

cgctgacctg gattaggccc agcagctccg tggccgccgc cgccccgcgg gggggcgggg    180

tggggaagtg cttcgtctcc ccgccccccc ccccccatcg ctgcctcgca ggaggcgaac    240

gccgcgaccc cagcggagcc cgcggcccag ccttgatccc ccaaccccgg gggctggcat    300

gagcggcccc tcggcggcac cgtggggcgg tggagtcgcc tccgcctgat ccccggcctg    360

tcgcccgacc ccacctcgcc aaccgaggcg gaccgcggag tgtgcgaacg accccaccgc    420

tgctttctcc tcccccagat cacgcacccc agctccggaa gatggggaac tgcctcaaat    480

cccccacctc ggatgacatc tccctgcttc acgagtctca gtccgaccgg gctagctttg    540

gcgaggggac ggagccggat caggagccgc cgccgccata tcaggtgtgt gatctgtatg    600

atggactttg tttatgggga cccaattcga tttctgccgt gcatgcacat ctatcacctg    660

gactgtatag atgactggtt gatgagatcc ttcacgtgcc cctcctgcat ggagccagtt    720

gatgcagcac tgctttcatc ctatgagact aattgagcca gggtctctta tctgacttca    780

agtgaaccac cattttggtg gttttgatct tttgtcactg agcccaaaga gccagggatt    840

aggaattaag atcgtgcaca aaagtttcct taaaattcct ggatggctgc agatgttggg    900

ggaaaaagta cgtgatattt tagaaactta gtgggaaaag taggatggta tttttatgta    960

aagccttgac ccaatgttta aaaatataat tgtatttaga tcttgttatt gctccagtac   1020

ataggaattg tgtaaagtgt taacagcagc tgtatttgtt taaattgtgt gtattgaaga   1080

ttaggaaaaa gatagtagtt atttttccta aatgaaataa ctttcttctc ttccccttcc   1140

ccacccgaat tcttttctga agttgctggc atttgggtca aggttttatt aaaagctaca   1200

ttttataaca ctggcacaca caaaaaagta gttttaagct tgtttgcaca gttctttttt   1260

tccattggaa atggaattca ttgccttagg tctttttaaa tagtgtatta ttatcgttgg   1320

ggctggctct atgcttgaaa accagtttat ttataacctg ttataagtgc tatattctgt   1380

ttgcagttag gaaatgcaga attcaaagtg atctcctagc ttgtaagcaa actgagatgc   1440

actatccctt ttctataaaa aataagttaa tgtgtcaaga aaccaactct attaaggtgg   1500

ggtttaatat taccctttcc tatgtgtttt atctaattat tttggttgtt aatatggtga   1560

taatggaaag tcaagttaaa ttttaaatat taagaattct gatttattga gattgaatta   1620

tgccaccacg tttatgtaaa aatgaaggtg gcaccgtggt gagacctaat gagaaatagt   1680

tactcagttg taaaaatttt gatttattct ctttcttctg acctccttgc ctcttgtctt   1740

gaaccatagc aaaaggatac tgcatctctc attactgtag tgctgaggtt attgaagtta   1800

tacaaaacac atctcagtct ctgtttcttg gaaaggtatc tattacatcc tgctagctga   1860

ctgacaaaac taagcaggga gaataaagat aattgtattt tatgttttgc acacaaacgc   1920

agaatttgta taaccatatg acttcatagt tgtgatctca aaaaagaagg aatttctcct   1980

ttgtttcttg cagttaatgt aagaatactt taaatctcta agcttctgaa gtgttagagg   2040

tagagatggt ctagtaaaga tgtagtagta atgttttatc catttagcat gtgtttattt   2100

tttcatatgt actcaaaggt gacttattgg ttcacctcag tgatattaca gctaaaaaaa   2160

tcattcatta gcaaaaggaa aagtggtctc aacctaacat cagaagtgtt tcttattatt   2220

attttatatt gagttgaata ttgaactcta acagttttct acatacaaaa cacagtgtca   2280

tgaaggttat tcataattgc attatagagg aatgtagtat gtcataagta ctttgtaaag   2340

atttgacatt caactgtagt atccatatgt tgcttaaatt tccttatgag ccccatgatg   2400

gaaagactta aagatgaatt tgagaaaaat tgaaagaaat tagattatca ggttctgtta   2460

aattgttaca tgtatcttgc ttaaatttct gtttattaat ttatatccac ccaagtacat   2520

aaagcaaatt tggaggaaac aactgaagtt gtgcaatatt ttctgataat tgcttttttt   2580

attcttgtgt tttctactta aacataatgt ctgtgtcatc aagtattata gtcagacttt   2640

tctttttttc tagattgtta aaattggcaa atgaactttt ttaaaaatca tcttccatgt   2700

tgcagttagt ctttcttttc attacaagtc tttcacagaa gtttggtggt aatattgaaa   2760

gaactagcat tgggcagaat gtgtcttttt taggcacttt atattctcaa catacaatgt   2820

taagaaccat caattttgac ttttactaag ttgttaaata aagttataat acagctgtga   2880

agggc                                                               2885


<210>  6264
<211>  87
<212>  PRT
<213>  Homosapiens

<400>  6264

Met Thr Ser Pro Cys Phe Thr Ser Leu Ser Pro Thr Gly Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Arg Ser Arg Ile Arg Ser Arg Arg Arg His Ile Arg Cys 
            20                  25                  30          


Val Ile Cys Met Met Asp Phe Val Tyr Gly Asp Pro Ile Arg Phe Leu 
        35                  40                  45              


Pro Cys Met His Ile Tyr His Leu Asp Cys Ile Asp Asp Trp Leu Met 
    50                  55                  60                  


Arg Ser Phe Thr Cys Pro Ser Cys Met Glu Pro Val Asp Ala Ala Leu 
65                  70                  75                  80  


Leu Ser Ser Tyr Glu Thr Asn 
                85          


<210>  6265
<211>  2973
<212>  DNA
<213>  Homosapiens

<400>  6265
ggctgccgcc gtctcgctga ggcggagtag gatgaggccc gcggccgtgg ctccggcgtc     60

ggcgggggca gcagcagctg aggcagcagc tgaggcagcc gcgacggccg cgcccccccc    120

cgctgacctg gattaggccc agcagctccg tggccgccgc cgccccgcgg gggggcgggg    180

tggggaagtg cttcgtctcc ccgccccccc ccccccatcg ctgcctcgca ggaggcgaac    240

gccgcgaccc cagcggagcc cgcggcccag ccttgatccc ccaaccccgg gggctggcat    300

gagcggcccc tcggcggcac cgtggggcgg tggagtcgcc tccgcctgat ccccggcctg    360

tcgcccgacc ccacctcgcc aaccgaggcg gaccgcggag tgtgcgaacg accccaccgc    420

tgctttctcc tcccccagat cacgcacccc agctccggaa gatggggaac tgcctcaaat    480

cccccacctc ggatgacatc tccctgcttc acgagtctca gtccgaccgg gctagctttg    540

gcgaggggac ggagccggat caggagccgc cgccgccata tcaggtgtgt gatctgtatg    600

atggactttg tttatgggga cccaattcga tttctgccgt gcatgcacat ctatcacctg    660

gactgtatag atgactggtt gatgagatcc ttcacgtgcc cctcctgcat ggagccagtt    720

gatgcagcac tgctttcatc ctatgagact aattgagcca gggtctctta tctgacttca    780

agtgaaccac cattttggtg gttttgatct tttgtcactg agcccaaaga gccagggatt    840

aggaattaag atcgtgcaca aaagtttcct taaaattcct ggatggctgc agatgttggg    900

ggaaaaagta cgtgatattt tagaaactta gtgggaaaag taggatggta tttttatgta    960

aagccttgac ccaatgttta aaaatataat tgtatttaga tcttgttatt gctccagtac   1020

ataggaattg tgtaaagtgt taacagcagc tgtatttgtt taaattgtgt gtattgaaga   1080

ttaggaaaaa gatagtagtt atttttccta aatgaaataa ctttcttctc ttccccttcc   1140

ccacccgaat tcttttctga agttgctggc atttgggtca aggttttatt aaaagctaca   1200

ttttataaca ctggcacaca caaaaaagta gttttaagct tgtttgcaca gttctttttt   1260

tccattggaa atggaattca ttgccttagg tctttttaaa tagtgtatta ttatcgttgg   1320

ggctggctct atgcttgaaa accagtttat ttataacctg ttataagtgc tatattctgt   1380

ttgcagttag gaaatgcaga attcaaagtg atctcctagc ttgtaagcaa actgagatgc   1440

actatccctt ttctataaaa aataagttaa tgtgtcaaga aaccaactct attaaggtgg   1500

ggtttaatat taccctttcc tatgtgtttt atctaattat tttggttgtt aatatggtga   1560

taatggaaag tcaagttaaa ttttaaatat taagaattct gatttattga gattgaatta   1620

tgccaccacg tttatgtaaa aatgaaggtg gcaccgtggt gagacctaat gagaaatagt   1680

tactcagttg taaaaatttt gatttattct ctttcttctg acctccttgc ctcttgtctt   1740

gaaccatagc aaaaggatac tgcatctctc attactgtag tgctgaggtt attgaagtta   1800

tacaaaacac atctcagtct ctgtttcttg gaaaggtatc tattacatcc tgctagctga   1860

ctgacaaaac taagcaggga gaataaagat aattgtattt tatgttttgc acacaaacgc   1920

agaatttgta taaccatatg acttcatagt tgtgatctca aaaaagaagg aatttctcct   1980

ttgtttcttg cagttaatgt aagaatactt taaatctcta agcttctgaa gtgttagagg   2040

tagagatggt ctagtaaaga tgtagtagta atgttttatc catttagcat gtgtttattt   2100

tttcatatgt actcaaaggt gacttattgg ttcacctcag tgatattaca gctaaaaaaa   2160

tcattcatta gcaaaaggaa aagtggtctc aacctaacat cagaagtgtt tcttattatt   2220

attttatatt gagttgaata ttgaactcta acagttttct acatacaaaa cacagtgtca   2280

tgaaggttat tcataattgc attatagagg aatgtagtat gtcataagta ctttgtaaag   2340

atttgacatt caactgtagt atccatatgt tgcttaaatt tccttatgag ccccatgatg   2400

gaaagactta aagatgaatt tgagaaaaat tgaaagaaat tagattatca ggttctgtta   2460

aattgttaca tgtatcttgc ttaaatttct gtttattaat ttatatccac ccaagtacat   2520

aaagcaaatt tggaggaaac aactgaagtt gtgcaatatt ttctgataat tgcttttttt   2580

attcttgtgt tttctactta aacataatgt ctgtgtcatc aagtattata gtcagacttt   2640

tctttttttc tagattgtta aaattggcaa atgaactttt ttaaaaatca tcttccatgt   2700

tgcagttagt ctttcttttc attacaagtc tttcacagaa gtttggtggt aatattgaaa   2760

gaactagcat tgggcagaat gtgtcttttt taggcacttt atattctcaa catacaatgt   2820

taagaaccat caattttgac ttttactaag ttgttaaata aagttataat acagctgtga   2880

agggctaaag ttagagttga ttacataagt aagtattccc catataatct tttaaaaagt   2940

tgtgtatgat tattttaaaa tctctctctc tat                                2973


<210>  6266
<211>  87
<212>  PRT
<213>  Homosapiens

<400>  6266

Met Thr Ser Pro Cys Phe Thr Ser Leu Ser Pro Thr Gly Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Arg Ser Arg Ile Arg Ser Arg Arg Arg His Ile Arg Cys 
            20                  25                  30          


Val Ile Cys Met Met Asp Phe Val Tyr Gly Asp Pro Ile Arg Phe Leu 
        35                  40                  45              


Pro Cys Met His Ile Tyr His Leu Asp Cys Ile Asp Asp Trp Leu Met 
    50                  55                  60                  


Arg Ser Phe Thr Cys Pro Ser Cys Met Glu Pro Val Asp Ala Ala Leu 
65                  70                  75                  80  


Leu Ser Ser Tyr Glu Thr Asn 
                85          


<210>  6267
<211>  3143
<212>  DNA
<213>  Homosapiens

<400>  6267
ggctgccgcc gtctcgctga ggcggagtag gatgaggccc gcggccgtgg ctccggcgtc     60

ggcgggggca gcagcagctg aggcagcagc tgaggcagcc gcgacggccg cgcccccccc    120

cgctgacctg gattaggccc agcagctccg tggccgccgc cgccccgcgg gggggcgggg    180

tggggaagtg cttcgtctcc ccgccccccc ccccccatcg ctgcctcgca ggaggcgaac    240

gccgcgaccc cagcggagcc cgcggcccag ccttgatccc ccaaccccgg gggctggcat    300

gagcggcccc tcggcggcac cgtggggcgg tggagtcgcc tccgcctgat ccccggcctg    360

tcgcccgacc ccacctcgcc aaccgaggcg gaccgcggag tgtgcgaacg accccaccgc    420

tgctttctcc tcccccagat cacgcacccc agctccggaa gatggggaac tgcctcaaat    480

cccccacctc ggatgacatc tccctgcttc acgagtctca gtccgaccgg gctagctttg    540

gcgaggggac ggagccggat caggagccgc cgccgccata tcaggaacaa gttccagttc    600

cagtctacca cccaacacct agccagactc ggctagcaac tcagctgact gaagaggaac    660

aaattaggat agctcaaaga ataggtctta tacaacatct gcctaaagga gtttatgacc    720

ctggaagaga tggatcagaa aaaaagatcc gggagtgtgt gatctgtatg atggactttg    780

tttatgggga cccaattcga tttctgccgt gcatgcacat ctatcacctg gactgtatag    840

atgactggtt gatgagatcc ttcacgtgcc cctcctgcat ggagccagtt gatgcagcac    900

tgctttcatc ctatgagact aattgagcca gggtctctta tctgacttca agtgaaccac    960

cattttggtg gttttgatct tttgtcactg agcccaaaga gccagggatt aggaattaag   1020

atcgtgcaca aaagtttcct taaaattcct ggatggctgc agatgttggg ggaaaaagta   1080

cgtgatattt tagaaactta gtgggaaaag taggatggta tttttatgta aagccttgac   1140

ccaatgttta aaaatataat tgtatttaga tcttgttatt gctccagtac ataggaattg   1200

tgtaaagtgt taacagcagc tgtatttgtt taaattgtgt gtattgaaga ttaggaaaaa   1260

gatagtagtt atttttccta aatgaaataa ctttcttctc ttccccttcc ccacccgaat   1320

tcttttctga agttgctggc atttgggtca aggttttatt aaaagctaca ttttataaca   1380

ctggcacaca caaaaaagta gttttaagct tgtttgcaca gttctttttt tccattggaa   1440

atggaattca ttgccttagg tctttttaaa tagtgtatta ttatcgttgg ggctggctct   1500

atgcttgaaa accagtttat ttataacctg ttataagtgc tatattctgt ttgcagttag   1560

gaaatgcaga attcaaagtg atctcctagc ttgtaagcaa actgagatgc actatccctt   1620

ttctataaaa aataagttaa tgtgtcaaga aaccaactct attaaggtgg ggtttaatat   1680

taccctttcc tatgtgtttt atctaattat tttggttgtt aatatggtga taatggaaag   1740

tcaagttaaa ttttaaatat taagaattct gatttattga gattgaatta tgccaccacg   1800

tttatgtaaa aatgaaggtg gcaccgtggt gagacctaat gagaaatagt tactcagttg   1860

taaaaatttt gatttattct ctttcttctg acctccttgc ctcttgtctt gaaccatagc   1920

aaaaggatac tgcatctctc attactgtag tgctgaggtt attgaagtta tacaaaacac   1980

atctcagtct ctgtttcttg gaaaggtatc tattacatcc tgctagctga ctgacaaaac   2040

taagcaggga gaataaagat aattgtattt tatgttttgc acacaaacgc agaatttgta   2100

taaccatatg acttcatagt tgtgatctca aaaaagaagg aatttctcct ttgtttcttg   2160

cagttaatgt aagaatactt taaatctcta agcttctgaa gtgttagagg tagagatggt   2220

ctagtaaaga tgtagtagta atgttttatc catttagcat gtgtttattt tttcatatgt   2280

actcaaaggt gacttattgg ttcacctcag tgatattaca gctaaaaaaa tcattcatta   2340

gcaaaaggaa aagtggtctc aacctaacat cagaagtgtt tcttattatt attttatatt   2400

gagttgaata ttgaactcta acagttttct acatacaaaa cacagtgtca tgaaggttat   2460

tcataattgc attatagagg aatgtagtat gtcataagta ctttgtaaag atttgacatt   2520

caactgtagt atccatatgt tgcttaaatt tccttatgag ccccatgatg gaaagactta   2580

aagatgaatt tgagaaaaat tgaaagaaat tagattatca ggttctgtta aattgttaca   2640

tgtatcttgc ttaaatttct gtttattaat ttatatccac ccaagtacat aaagcaaatt   2700

tggaggaaac aactgaagtt gtgcaatatt ttctgataat tgcttttttt attcttgtgt   2760

tttctactta aacataatgt ctgtgtcatc aagtattata gtcagacttt tctttttttc   2820

tagattgtta aaattggcaa atgaactttt ttaaaaatca tcttccatgt tgcagttagt   2880

ctttcttttc attacaagtc tttcacagaa gtttggtggt aatattgaaa gaactagcat   2940

tgggcagaat gtgtcttttt taggcacttt atattctcaa catacaatgt taagaaccat   3000

caattttgac ttttactaag ttgttaaata aagttataat acagctgtga agggctaaag   3060

ttagagttga ttacataagt aagtattccc catataatct tttaaaaagt tgtgtatgat   3120

tattttaaaa tctctctctc tat                                           3143


<210>  6268
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  6268

Met Gly Asn Cys Leu Lys Ser Pro Thr Ser Asp Asp Ile Ser Leu Leu 
1               5                   10                  15      


His Glu Ser Gln Ser Asp Arg Ala Ser Phe Gly Glu Gly Thr Glu Pro 
            20                  25                  30          


Asp Gln Glu Pro Pro Pro Pro Tyr Gln Glu Gln Val Pro Val Pro Val 
        35                  40                  45              


Tyr His Pro Thr Pro Ser Gln Thr Arg Leu Ala Thr Gln Leu Thr Glu 
    50                  55                  60                  


Glu Glu Gln Ile Arg Ile Ala Gln Arg Ile Gly Leu Ile Gln His Leu 
65                  70                  75                  80  


Pro Lys Gly Val Tyr Asp Pro Gly Arg Asp Gly Ser Glu Lys Lys Ile 
                85                  90                  95      


Arg Glu Cys Val Ile Cys Met Met Asp Phe Val Tyr Gly Asp Pro Ile 
            100                 105                 110         


Arg Phe Leu Pro Cys Met His Ile Tyr His Leu Asp Cys Ile Asp Asp 
        115                 120                 125             


Trp Leu Met Arg Ser Phe Thr Cys Pro Ser Cys Met Glu Pro Val Asp 
    130                 135                 140                 


Ala Ala Leu Leu Ser Ser Tyr Glu Thr Asn 
145                 150                 


<210>  6269
<211>  2591
<212>  DNA
<213>  Homosapiens

<400>  6269
gtcggcgggg gcagcagcag ctgaggcagc agctgaggca gccgcgacgg ccgcgccccc     60

ccccgctgac ctggattagg cccagcagct cccgctgcct cgcaggaggc gaacgccgcg    120

accccagcgg agcccgcggc ccagccttga tcccccaacc ccgggggctg gcatgagcgg    180

cccctcggcg gcaccgtggg gcggtggagt cgcctccgcc tgatccccgg cctgtcgccc    240

gaccccacct cgccaaccga ggcggaccgc ggagtgtgcg aacgacccca ccgctgcttt    300

ctcctccccc agatcacgca ccccagctcc ggaagatggg gaactgcctc aaatccccca    360

cctcggatga catctccctg cttcacgagt ctcagtccga ccgggctagc tttggcgagg    420

ggacggagcc ggatcaggag ccgccgccgc catatcagga acaagttcca gttccagtct    480

accacccaac acctagccag actcggctag caactcagct gactgaagag gaacaaatta    540

ggatagctca aagaataggt cttatacaac atctgcctaa aggagtttat gaccctggaa    600

gagatggatc agaaaaaaag atccgggagt gtgtgatctg tatgatggac tttgtttatg    660

gggacccaat tcgatttctg ccgtgcatgc acatctatca cctggactgt atagatgact    720

ggttgatgag atccttcacg tgcccctcct gcatggagcc agttgatgca gcactgcttt    780

catcctatga gactaattga gccagggtct cttatctgac ttcaagtgaa ccaccatttt    840

ggtggttttg atcttttgtc actgagccca aagagccagg gattaggaat taagatcgtg    900

cacaaaagtt tccttaaaat tcctggatgg ctgcagatgt tgggggaaaa agtacgtgat    960

attttagaaa cttagtggga aaagtaggat ggtattttta tgtaaagcct tgacccaatg   1020

tttaaaaata taattgtatt tagatcttgt tattgctcca gtacatagga attgtgtaaa   1080

gtgttaacag cagctgtatt tgtttaaatt gtgtgtattg aagattagga aaaagatagt   1140

agttattttt cctaaatgaa ataactttct tctcttcccc ttccccaccc gaattctttt   1200

ctgaagttgc tggcatttgg gtcaaggttt tattaaaagc tacattttat aacactggca   1260

cacacaaaaa agtagtttta agcttgtttg cacagttctt tttttccatt ggaaatggaa   1320

ttcattgcct taggtctttt taaatagtgt attattatcg ttggggctgg ctctatgctt   1380

gaaaaccagt ttatttataa cctgttataa gtgctatatt ctgtttgcag ttaggaaatg   1440

cagaattcaa agtgatctcc tagcttgtaa gcaaactgag atgcactatc ccttttctat   1500

aaaaaataag ttaatgtgtc aagaaaccaa ctctattaag gtggggttta atattaccct   1560

ttcctatgtg ttttatctaa ttattttggt tgttaatatg gtgataatgg aaagtcaagt   1620

taaattttaa atattaagaa ttctgattta ttgagattga attatgccac cacgtttatg   1680

taaaaatgaa ggtggcaccg tggtgagacc taatgagaaa tagttactca gttgtaaaaa   1740

ttttgattta ttctctttct tctgacctcc ttgcctcttg tcttgaacca tagcaaaagg   1800

atactgcatc tctcattact gtagtgctga ggttattgaa gttatacaaa acacatctca   1860

gtctctgttt cttggaaagg tatctattac atcctgctag ctgactgaca aaactaagca   1920

gggagaataa agataattgt attttatgtt ttgcacacaa acgcagaatt tgtataacca   1980

tatgacttca tagttgtgat ctcaaaaaag aaggaatttc tcctttgttt cttgcagtta   2040

atgtaagaat actttaaatc tctaagcttc tgaagtgtta gaggtagaga tggtctagta   2100

aagatgtagt agtaatgttt tatccattta gcatgtgttt attttttcat atgtactcaa   2160

aggtgactta ttggttcacc tcagtgatat tacagctaaa aaaatcattc attagcaaaa   2220

ggaaaagtgg tctcaaccta acatcagaag tgtttcttat tattatttta tattgagttg   2280

aatattgaac tctaacagtt ttctacatac aaaacacagt gtcatgaagg ttattcataa   2340

ttgcattata gaggaatgta gtatgtcata agtactttgt aaagatttga cattcaactg   2400

tagtatccat atgttgctta aatttcctta tgagccccat gatggaaaga cttaaagatg   2460

aatttgagaa aaattgaaag aaattagatt atcaggttct gttaaattgt tacatgtatc   2520

ttgcttaaat ttctgtttat taatttatat ccacccaagt acataaagca aatttggagg   2580

aaacaactga a                                                        2591


<210>  6270
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  6270

Met Gly Asn Cys Leu Lys Ser Pro Thr Ser Asp Asp Ile Ser Leu Leu 
1               5                   10                  15      


His Glu Ser Gln Ser Asp Arg Ala Ser Phe Gly Glu Gly Thr Glu Pro 
            20                  25                  30          


Asp Gln Glu Pro Pro Pro Pro Tyr Gln Glu Gln Val Pro Val Pro Val 
        35                  40                  45              


Tyr His Pro Thr Pro Ser Gln Thr Arg Leu Ala Thr Gln Leu Thr Glu 
    50                  55                  60                  


Glu Glu Gln Ile Arg Ile Ala Gln Arg Ile Gly Leu Ile Gln His Leu 
65                  70                  75                  80  


Pro Lys Gly Val Tyr Asp Pro Gly Arg Asp Gly Ser Glu Lys Lys Ile 
                85                  90                  95      


Arg Glu Cys Val Ile Cys Met Met Asp Phe Val Tyr Gly Asp Pro Ile 
            100                 105                 110         


Arg Phe Leu Pro Cys Met His Ile Tyr His Leu Asp Cys Ile Asp Asp 
        115                 120                 125             


Trp Leu Met Arg Ser Phe Thr Cys Pro Ser Cys Met Glu Pro Val Asp 
    130                 135                 140                 


Ala Ala Leu Leu Ser Ser Tyr Glu Thr Asn 
145                 150                 


<210>  6271
<211>  2733
<212>  DNA
<213>  Homosapiens

<400>  6271
gtcggcgggg gcagcagcag ctgaggcagc agctgaggca gccgcgacgg ccgcgccccc     60

ccccgctgac ctggattagg cccagcagct cccgctgcct cgcaggaggc gaacgccgcg    120

accccagcgg agcccgcggc ccagccttga tcccccaacc ccgggggctg gcatgagcgg    180

cccctcggcg gcaccgtggg gcggtggagt cgcctccgcc tgatccccgg cctgtcgccc    240

gaccccacct cgccaaccga ggcggaccgc ggagtgtgcg aacgacccca ccgctgcttt    300

ctcctccccc agatcacgca ccccagctcc ggaagatggg gaactgcctc aaatccccca    360

cctcggatga catctccctg cttcacgagt ctcagtccga ccgggctagc tttggcgagg    420

ggacggagcc ggatcaggag ccgccgccgc catatcagga acaagttcca gttccagtct    480

accacccaac acctagccag actcggctag caactcagct gactgaagag gaacaaatta    540

ggatagctca aagaataggt cttatacaac atctgcctaa aggagtttat gaccctggaa    600

gagatggatc agaaaaaaag atccgggagt gtgtgatctg tatgatggac tttgtttatg    660

gggacccaat tcgatttctg ccgtgcatgc acatctatca cctggactgt atagatgact    720

ggttgatgag atccttcacg tgcccctcct gcatggagcc agttgatgca gcactgcttt    780

catcctatga gactaattga gccagggtct cttatctgac ttcaagtgaa ccaccatttt    840

ggtggttttg atcttttgtc actgagccca aagagccagg gattaggaat taagatcgtg    900

cacaaaagtt tccttaaaat tcctggatgg ctgcagatgt tgggggaaaa agtacgtgat    960

attttagaaa cttagtggga aaagtaggat ggtattttta tgtaaagcct tgacccaatg   1020

tttaaaaata taattgtatt tagatcttgt tattgctcca gtacatagga attgtgtaaa   1080

gtgttaacag cagctgtatt tgtttaaatt gtgtgtattg aagattagga aaaagatagt   1140

agttattttt cctaaatgaa ataactttct tctcttcccc ttccccaccc gaattctttt   1200

ctgaagttgc tggcatttgg gtcaaggttt tattaaaagc tacattttat aacactggca   1260

cacacaaaaa agtagtttta agcttgtttg cacagttctt tttttccatt ggaaatggaa   1320

ttcattgcct taggtctttt taaatagtgt attattatcg ttggggctgg ctctatgctt   1380

gaaaaccagt ttatttataa cctgttataa gtgctatatt ctgtttgcag ttaggaaatg   1440

cagaattcaa agtgatctcc tagcttgtaa gcaaactgag atgcactatc ccttttctat   1500

aaaaaataag ttaatgtgtc aagaaaccaa ctctattaag gtggggttta atattaccct   1560

ttcctatgtg ttttatctaa ttattttggt tgttaatatg gtgataatgg aaagtcaagt   1620

taaattttaa atattaagaa ttctgattta ttgagattga attatgccac cacgtttatg   1680

taaaaatgaa ggtggcaccg tggtgagacc taatgagaaa tagttactca gttgtaaaaa   1740

ttttgattta ttctctttct tctgacctcc ttgcctcttg tcttgaacca tagcaaaagg   1800

atactgcatc tctcattact gtagtgctga ggttattgaa gttatacaaa acacatctca   1860

gtctctgttt cttggaaagg tatctattac atcctgctag ctgactgaca aaactaagca   1920

gggagaataa agataattgt attttatgtt ttgcacacaa acgcagaatt tgtataacca   1980

tatgacttca tagttgtgat ctcaaaaaag aaggaatttc tcctttgttt cttgcagtta   2040

atgtaagaat actttaaatc tctaagcttc tgaagtgtta gaggtagaga tggtctagta   2100

aagatgtagt agtaatgttt tatccattta gcatgtgttt attttttcat atgtactcaa   2160

aggtgactta ttggttcacc tcagtgatat tacagctaaa aaaatcattc attagcaaaa   2220

ggaaaagtgg tctcaaccta acatcagaag tgtttcttat tattatttta tattgagttg   2280

aatattgaac tctaacagtt ttctacatac aaaacacagt gtcatgaagg ttattcataa   2340

ttgcattata gaggaatgta gtatgtcata agtactttgt aaagatttga cattcaactg   2400

tagtatccat atgttgctta aatttcctta tgagccccat gatggaaaga cttaaagatg   2460

aatttgagaa aaattgaaag aaattagatt atcaggttct gttaaattgt tacatgtatc   2520

ttgcttaaat ttctgtttat taatttatat ccacccaagt acataaagca aatttggagg   2580

aaacaactga agttgtgcaa tattttctga taattgcttt ttttattctt gtgttttcta   2640

cttaaacata atgtctgtgt catcaagtat tatagtcaga cttttctttt tttctagatt   2700

gttaaaattg gcaaatgaac ttttttaaaa atc                                2733


<210>  6272
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  6272

Met Gly Asn Cys Leu Lys Ser Pro Thr Ser Asp Asp Ile Ser Leu Leu 
1               5                   10                  15      


His Glu Ser Gln Ser Asp Arg Ala Ser Phe Gly Glu Gly Thr Glu Pro 
            20                  25                  30          


Asp Gln Glu Pro Pro Pro Pro Tyr Gln Glu Gln Val Pro Val Pro Val 
        35                  40                  45              


Tyr His Pro Thr Pro Ser Gln Thr Arg Leu Ala Thr Gln Leu Thr Glu 
    50                  55                  60                  


Glu Glu Gln Ile Arg Ile Ala Gln Arg Ile Gly Leu Ile Gln His Leu 
65                  70                  75                  80  


Pro Lys Gly Val Tyr Asp Pro Gly Arg Asp Gly Ser Glu Lys Lys Ile 
                85                  90                  95      


Arg Glu Cys Val Ile Cys Met Met Asp Phe Val Tyr Gly Asp Pro Ile 
            100                 105                 110         


Arg Phe Leu Pro Cys Met His Ile Tyr His Leu Asp Cys Ile Asp Asp 
        115                 120                 125             


Trp Leu Met Arg Ser Phe Thr Cys Pro Ser Cys Met Glu Pro Val Asp 
    130                 135                 140                 


Ala Ala Leu Leu Ser Ser Tyr Glu Thr Asn 
145                 150                 


<210>  6273
<211>  2929
<212>  DNA
<213>  Homosapiens

<400>  6273
gtcggcgggg gcagcagcag ctgaggcagc agctgaggca gccgcgacgg ccgcgccccc     60

ccccgctgac ctggattagg cccagcagct cccgctgcct cgcaggaggc gaacgccgcg    120

accccagcgg agcccgcggc ccagccttga tcccccaacc ccgggggctg gcatgagcgg    180

cccctcggcg gcaccgtggg gcggtggagt cgcctccgcc tgatccccgg cctgtcgccc    240

gaccccacct cgccaaccga ggcggaccgc ggagtgtgcg aacgacccca ccgctgcttt    300

ctcctccccc agatcacgca ccccagctcc ggaagatggg gaactgcctc aaatccccca    360

cctcggatga catctccctg cttcacgagt ctcagtccga ccgggctagc tttggcgagg    420

ggacggagcc ggatcaggag ccgccgccgc catatcagga acaagttcca gttccagtct    480

accacccaac acctagccag actcggctag caactcagct gactgaagag gaacaaatta    540

ggatagctca aagaataggt cttatacaac atctgcctaa aggagtttat gaccctggaa    600

gagatggatc agaaaaaaag atccgggagt gtgtgatctg tatgatggac tttgtttatg    660

gggacccaat tcgatttctg ccgtgcatgc acatctatca cctggactgt atagatgact    720

ggttgatgag atccttcacg tgcccctcct gcatggagcc agttgatgca gcactgcttt    780

catcctatga gactaattga gccagggtct cttatctgac ttcaagtgaa ccaccatttt    840

ggtggttttg atcttttgtc actgagccca aagagccagg gattaggaat taagatcgtg    900

cacaaaagtt tccttaaaat tcctggatgg ctgcagatgt tgggggaaaa agtacgtgat    960

attttagaaa cttagtggga aaagtaggat ggtattttta tgtaaagcct tgacccaatg   1020

tttaaaaata taattgtatt tagatcttgt tattgctcca gtacatagga attgtgtaaa   1080

gtgttaacag cagctgtatt tgtttaaatt gtgtgtattg aagattagga aaaagatagt   1140

agttattttt cctaaatgaa ataactttct tctcttcccc ttccccaccc gaattctttt   1200

ctgaagttgc tggcatttgg gtcaaggttt tattaaaagc tacattttat aacactggca   1260

cacacaaaaa agtagtttta agcttgtttg cacagttctt tttttccatt ggaaatggaa   1320

ttcattgcct taggtctttt taaatagtgt attattatcg ttggggctgg ctctatgctt   1380

gaaaaccagt ttatttataa cctgttataa gtgctatatt ctgtttgcag ttaggaaatg   1440

cagaattcaa agtgatctcc tagcttgtaa gcaaactgag atgcactatc ccttttctat   1500

aaaaaataag ttaatgtgtc aagaaaccaa ctctattaag gtggggttta atattaccct   1560

ttcctatgtg ttttatctaa ttattttggt tgttaatatg gtgataatgg aaagtcaagt   1620

taaattttaa atattaagaa ttctgattta ttgagattga attatgccac cacgtttatg   1680

taaaaatgaa ggtggcaccg tggtgagacc taatgagaaa tagttactca gttgtaaaaa   1740

ttttgattta ttctctttct tctgacctcc ttgcctcttg tcttgaacca tagcaaaagg   1800

atactgcatc tctcattact gtagtgctga ggttattgaa gttatacaaa acacatctca   1860

gtctctgttt cttggaaagg tatctattac atcctgctag ctgactgaca aaactaagca   1920

gggagaataa agataattgt attttatgtt ttgcacacaa acgcagaatt tgtataacca   1980

tatgacttca tagttgtgat ctcaaaaaag aaggaatttc tcctttgttt cttgcagtta   2040

atgtaagaat actttaaatc tctaagcttc tgaagtgtta gaggtagaga tggtctagta   2100

aagatgtagt agtaatgttt tatccattta gcatgtgttt attttttcat atgtactcaa   2160

aggtgactta ttggttcacc tcagtgatat tacagctaaa aaaatcattc attagcaaaa   2220

ggaaaagtgg tctcaaccta acatcagaag tgtttcttat tattatttta tattgagttg   2280

aatattgaac tctaacagtt ttctacatac aaaacacagt gtcatgaagg ttattcataa   2340

ttgcattata gaggaatgta gtatgtcata agtactttgt aaagatttga cattcaactg   2400

tagtatccat atgttgctta aatttcctta tgagccccat gatggaaaga cttaaagatg   2460

aatttgagaa aaattgaaag aaattagatt atcaggttct gttaaattgt tacatgtatc   2520

ttgcttaaat ttctgtttat taatttatat ccacccaagt acataaagca aatttggagg   2580

aaacaactga agttgtgcaa tattttctga taattgcttt ttttattctt gtgttttcta   2640

cttaaacata atgtctgtgt catcaagtat tatagtcaga cttttctttt tttctagatt   2700

gttaaaattg gcaaatgaac ttttttaaaa atcatcttcc atgttgcagt tagtctttct   2760

tttcattaca agtctttcac agaagtttgg tggtaatatt gaaagaacta gcattgggca   2820

gaatgtgtct tttttaggca ctttatattc tcaacataca atgttaagaa ccatcaattt   2880

tgacttttac taagttgtta aataaagtta taatacagct gtgaagggc               2929


<210>  6274
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  6274

Met Gly Asn Cys Leu Lys Ser Pro Thr Ser Asp Asp Ile Ser Leu Leu 
1               5                   10                  15      


His Glu Ser Gln Ser Asp Arg Ala Ser Phe Gly Glu Gly Thr Glu Pro 
            20                  25                  30          


Asp Gln Glu Pro Pro Pro Pro Tyr Gln Glu Gln Val Pro Val Pro Val 
        35                  40                  45              


Tyr His Pro Thr Pro Ser Gln Thr Arg Leu Ala Thr Gln Leu Thr Glu 
    50                  55                  60                  


Glu Glu Gln Ile Arg Ile Ala Gln Arg Ile Gly Leu Ile Gln His Leu 
65                  70                  75                  80  


Pro Lys Gly Val Tyr Asp Pro Gly Arg Asp Gly Ser Glu Lys Lys Ile 
                85                  90                  95      


Arg Glu Cys Val Ile Cys Met Met Asp Phe Val Tyr Gly Asp Pro Ile 
            100                 105                 110         


Arg Phe Leu Pro Cys Met His Ile Tyr His Leu Asp Cys Ile Asp Asp 
        115                 120                 125             


Trp Leu Met Arg Ser Phe Thr Cys Pro Ser Cys Met Glu Pro Val Asp 
    130                 135                 140                 


Ala Ala Leu Leu Ser Ser Tyr Glu Thr Asn 
145                 150                 


<210>  6275
<211>  3017
<212>  DNA
<213>  Homosapiens

<400>  6275
gtcggcgggg gcagcagcag ctgaggcagc agctgaggca gccgcgacgg ccgcgccccc     60

ccccgctgac ctggattagg cccagcagct cccgctgcct cgcaggaggc gaacgccgcg    120

accccagcgg agcccgcggc ccagccttga tcccccaacc ccgggggctg gcatgagcgg    180

cccctcggcg gcaccgtggg gcggtggagt cgcctccgcc tgatccccgg cctgtcgccc    240

gaccccacct cgccaaccga ggcggaccgc ggagtgtgcg aacgacccca ccgctgcttt    300

ctcctccccc agatcacgca ccccagctcc ggaagatggg gaactgcctc aaatccccca    360

cctcggatga catctccctg cttcacgagt ctcagtccga ccgggctagc tttggcgagg    420

ggacggagcc ggatcaggag ccgccgccgc catatcagga acaagttcca gttccagtct    480

accacccaac acctagccag actcggctag caactcagct gactgaagag gaacaaatta    540

ggatagctca aagaataggt cttatacaac atctgcctaa aggagtttat gaccctggaa    600

gagatggatc agaaaaaaag atccgggagt gtgtgatctg tatgatggac tttgtttatg    660

gggacccaat tcgatttctg ccgtgcatgc acatctatca cctggactgt atagatgact    720

ggttgatgag atccttcacg tgcccctcct gcatggagcc agttgatgca gcactgcttt    780

catcctatga gactaattga gccagggtct cttatctgac ttcaagtgaa ccaccatttt    840

ggtggttttg atcttttgtc actgagccca aagagccagg gattaggaat taagatcgtg    900

cacaaaagtt tccttaaaat tcctggatgg ctgcagatgt tgggggaaaa agtacgtgat    960

attttagaaa cttagtggga aaagtaggat ggtattttta tgtaaagcct tgacccaatg   1020

tttaaaaata taattgtatt tagatcttgt tattgctcca gtacatagga attgtgtaaa   1080

gtgttaacag cagctgtatt tgtttaaatt gtgtgtattg aagattagga aaaagatagt   1140

agttattttt cctaaatgaa ataactttct tctcttcccc ttccccaccc gaattctttt   1200

ctgaagttgc tggcatttgg gtcaaggttt tattaaaagc tacattttat aacactggca   1260

cacacaaaaa agtagtttta agcttgtttg cacagttctt tttttccatt ggaaatggaa   1320

ttcattgcct taggtctttt taaatagtgt attattatcg ttggggctgg ctctatgctt   1380

gaaaaccagt ttatttataa cctgttataa gtgctatatt ctgtttgcag ttaggaaatg   1440

cagaattcaa agtgatctcc tagcttgtaa gcaaactgag atgcactatc ccttttctat   1500

aaaaaataag ttaatgtgtc aagaaaccaa ctctattaag gtggggttta atattaccct   1560

ttcctatgtg ttttatctaa ttattttggt tgttaatatg gtgataatgg aaagtcaagt   1620

taaattttaa atattaagaa ttctgattta ttgagattga attatgccac cacgtttatg   1680

taaaaatgaa ggtggcaccg tggtgagacc taatgagaaa tagttactca gttgtaaaaa   1740

ttttgattta ttctctttct tctgacctcc ttgcctcttg tcttgaacca tagcaaaagg   1800

atactgcatc tctcattact gtagtgctga ggttattgaa gttatacaaa acacatctca   1860

gtctctgttt cttggaaagg tatctattac atcctgctag ctgactgaca aaactaagca   1920

gggagaataa agataattgt attttatgtt ttgcacacaa acgcagaatt tgtataacca   1980

tatgacttca tagttgtgat ctcaaaaaag aaggaatttc tcctttgttt cttgcagtta   2040

atgtaagaat actttaaatc tctaagcttc tgaagtgtta gaggtagaga tggtctagta   2100

aagatgtagt agtaatgttt tatccattta gcatgtgttt attttttcat atgtactcaa   2160

aggtgactta ttggttcacc tcagtgatat tacagctaaa aaaatcattc attagcaaaa   2220

ggaaaagtgg tctcaaccta acatcagaag tgtttcttat tattatttta tattgagttg   2280

aatattgaac tctaacagtt ttctacatac aaaacacagt gtcatgaagg ttattcataa   2340

ttgcattata gaggaatgta gtatgtcata agtactttgt aaagatttga cattcaactg   2400

tagtatccat atgttgctta aatttcctta tgagccccat gatggaaaga cttaaagatg   2460

aatttgagaa aaattgaaag aaattagatt atcaggttct gttaaattgt tacatgtatc   2520

ttgcttaaat ttctgtttat taatttatat ccacccaagt acataaagca aatttggagg   2580

aaacaactga agttgtgcaa tattttctga taattgcttt ttttattctt gtgttttcta   2640

cttaaacata atgtctgtgt catcaagtat tatagtcaga cttttctttt tttctagatt   2700

gttaaaattg gcaaatgaac ttttttaaaa atcatcttcc atgttgcagt tagtctttct   2760

tttcattaca agtctttcac agaagtttgg tggtaatatt gaaagaacta gcattgggca   2820

gaatgtgtct tttttaggca ctttatattc tcaacataca atgttaagaa ccatcaattt   2880

tgacttttac taagttgtta aataaagtta taatacagct gtgaagggct aaagttagag   2940

ttgattacat aagtaagtat tccccatata atcttttaaa aagttgtgta tgattatttt   3000

aaaatctctc tctctat                                                  3017


<210>  6276
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  6276

Met Gly Asn Cys Leu Lys Ser Pro Thr Ser Asp Asp Ile Ser Leu Leu 
1               5                   10                  15      


His Glu Ser Gln Ser Asp Arg Ala Ser Phe Gly Glu Gly Thr Glu Pro 
            20                  25                  30          


Asp Gln Glu Pro Pro Pro Pro Tyr Gln Glu Gln Val Pro Val Pro Val 
        35                  40                  45              


Tyr His Pro Thr Pro Ser Gln Thr Arg Leu Ala Thr Gln Leu Thr Glu 
    50                  55                  60                  


Glu Glu Gln Ile Arg Ile Ala Gln Arg Ile Gly Leu Ile Gln His Leu 
65                  70                  75                  80  


Pro Lys Gly Val Tyr Asp Pro Gly Arg Asp Gly Ser Glu Lys Lys Ile 
                85                  90                  95      


Arg Glu Cys Val Ile Cys Met Met Asp Phe Val Tyr Gly Asp Pro Ile 
            100                 105                 110         


Arg Phe Leu Pro Cys Met His Ile Tyr His Leu Asp Cys Ile Asp Asp 
        115                 120                 125             


Trp Leu Met Arg Ser Phe Thr Cys Pro Ser Cys Met Glu Pro Val Asp 
    130                 135                 140                 


Ala Ala Leu Leu Ser Ser Tyr Glu Thr Asn 
145                 150                 


<210>  6277
<211>  643
<212>  DNA
<213>  Homosapiens

<400>  6277
gacaacatcc atcattttat aggtgcttca tttatatatt aacaaacaac cggaatgctt     60

cagagatttt tcgcatcaga tcagaccttg ctgtttttga tgtttgaccc tatcttctgg    120

ccgggtgcag tggctcacac ctgtatcaca cctgtaatcc caacactttg ggaggccaag    180

gcaggtggat cacttgaggc caggattcga gaccagcctg gccaacatgg tgaaaccctg    240

tctctactaa aaataaaaaa attagctggg cgtggtggcg cgtgcctgta ctcccagcta    300

ctcccaggtt caagcaattc tcatgtcgca gcctccagag tagctgggat aacagagcta    360

aatgactgca tctggcctcc aaccctttat taagataggt attttgtctg ttatgctgat    420

gaggaacctt aatgctcaga gatattaaga agcttgcgta aggccacata cataattaaa    480

taccagagca gaaattccag ggaatgcctg tactctttcc attatgtatt tttgttcatt    540

aacctaggta gggggcatag aaattctgag tttgagaggc atgtggaagg aagtatattt    600

ggtttggttt tggacctatt gaagttcctg tgggatgggt agg                      643


<210>  6278
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  6278

Met Leu Gln Arg Phe Phe Ala Ser Asp Gln Thr Leu Leu Phe Leu Met 
1               5                   10                  15      


Phe Asp Pro Ile Phe Trp Pro Gly Ala Val Ala His Thr Cys Ile Thr 
            20                  25                  30          


Pro Val Ile Pro Thr Leu Trp Glu Ala Lys Ala Gly Gly Ser Leu Glu 
        35                  40                  45              


Ala Arg Ile Arg Asp Gln Pro Gly Gln His Gly Glu Thr Leu Ser Leu 
    50                  55                  60                  


Leu Lys Ile Lys Lys Leu Ala Gly Arg Gly Gly Ala Cys Leu Tyr Ser 
65                  70                  75                  80  


Gln Leu Leu Pro Gly Ser Ser Asn Ser His Val Ala Ala Ser Arg Val 
                85                  90                  95      


Ala Gly Ile Thr Glu Leu Asn Asp Cys Ile Trp Pro Pro Thr Leu Tyr 
            100                 105                 110         


<210>  6279
<211>  2171
<212>  DNA
<213>  Homosapiens

<400>  6279
aaaaaataat ctttttcctc tatattttaa tattttagga acaagttcca gttccagtct     60

accacccaac acctagccag actcggctag caactcagct gactgaagag gaacaaatta    120

ggatagctca aagaataggt cttatacaac atctgcctaa aggagtttat gaccctggaa    180

gagatggatc agaaaaaaag atccgggagt gtgtgatctg tatgatggac tttgtttatg    240

gggacccaat tcgatttctg ccgtgcatgc acatctatca cctggactgt atagatgact    300

ggttgatgag atccttcacg tgcccctcct gcatggagcc agttgatgca gcactgcttt    360

catcctatga gactaattga gccagggtct cttatctgac ttcaagtgaa ccaccatttt    420

ggtggttttg atcttttgtc actgagccca aagagccagg gattaggaat taagatcgtg    480

cacaaaagtt tccttaaaat tcctggatgg ctgcagatgt tgggggaaaa agtacgtgat    540

attttagaaa cttagtggga aaagtaggat ggtattttta tgtaaagcct tgacccaatg    600

tttaaaaata taattgtatt tagatcttgt tattgctcca gtacatagga attgtgtaaa    660

gtgttaacag cagctgtatt tgtttaaatt gtgtgtattg aagattagga aaaagatagt    720

agttattttt cctaaatgaa ataactttct tctcttcccc ttccccaccc gaattctttt    780

ctgaagttgc tggcatttgg gtcaaggttt tattaaaagc tacattttat aacactggca    840

cacacaaaaa agtagtttta agcttgtttg cacagttctt tttttccatt ggaaatggaa    900

ttcattgcct taggtctttt taaatagtgt attattatcg ttggggctgg ctctatgctt    960

gaaaaccagt ttatttataa cctgttataa gtgctatatt ctgtttgcag ttaggaaatg   1020

cagaattcaa agtgatctcc tagcttgtaa gcaaactgag atgcactatc ccttttctat   1080

aaaaaataag ttaatgtgtc aagaaaccaa ctctattaag gtggggttta atattaccct   1140

ttcctatgtg ttttatctaa ttattttggt tgttaatatg gtgataatgg aaagtcaagt   1200

taaattttaa atattaagaa ttctgattta ttgagattga attatgccac cacgtttatg   1260

taaaaatgaa ggtggcaccg tggtgagacc taatgagaaa tagttactca gttgtaaaaa   1320

ttttgattta ttctctttct tctgacctcc ttgcctcttg tcttgaacca tagcaaaagg   1380

atactgcatc tctcattact gtagtgctga ggttattgaa gttatacaaa acacatctca   1440

gtctctgttt cttggaaagg tatctattac atcctgctag ctgactgaca aaactaagca   1500

gggagaataa agataattgt attttatgtt ttgcacacaa acgcagaatt tgtataacca   1560

tatgacttca tagttgtgat ctcaaaaaag aaggaatttc tcctttgttt cttgcagtta   1620

atgtaagaat actttaaatc tctaagcttc tgaagtgtta gaggtagaga tggtctagta   1680

aagatgtagt agtaatgttt tatccattta gcatgtgttt attttttcat atgtactcaa   1740

aggtgactta ttggttcacc tcagtgatat tacagctaaa aaaatcattc attagcaaaa   1800

ggaaaagtgg tctcaaccta acatcagaag tgtttcttat tattatttta tattgagttg   1860

aatattgaac tctaacagtt ttctacatac aaaacacagt gtcatgaagg ttattcataa   1920

ttgcattata gaggaatgta gtatgtcata agtactttgt aaagatttga cattcaactg   1980

tagtatccat atgttgctta aatttcctta tgagccccat gatggaaaga cttaaagatg   2040

aatttgagaa aaattgaaag aaattagatt atcaggttct gttaaattgt tacatgtatc   2100

ttgcttaaat ttctgtttat taatttatat ccacccaagt acataaagca aatttggagg   2160

aaacaactga a                                                        2171


<210>  6280
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6280

Met Phe Tyr Pro Phe Ser Met Cys Leu Phe Phe His Met Tyr Ser Lys 
1               5                   10                  15      


Val Thr Tyr Trp Phe Thr Ser Val Ile Leu Gln Leu Lys Lys Ser Phe 
            20                  25                  30          


Ile Ser Lys Arg Lys Ser Gly Leu Asn Leu Thr Ser Glu Val Phe Leu 
        35                  40                  45              


Ile Ile Ile Leu Tyr 
    50              


<210>  6281
<211>  2313
<212>  DNA
<213>  Homosapiens

<400>  6281
aaaaaataat ctttttcctc tatattttaa tattttagga acaagttcca gttccagtct     60

accacccaac acctagccag actcggctag caactcagct gactgaagag gaacaaatta    120

ggatagctca aagaataggt cttatacaac atctgcctaa aggagtttat gaccctggaa    180

gagatggatc agaaaaaaag atccgggagt gtgtgatctg tatgatggac tttgtttatg    240

gggacccaat tcgatttctg ccgtgcatgc acatctatca cctggactgt atagatgact    300

ggttgatgag atccttcacg tgcccctcct gcatggagcc agttgatgca gcactgcttt    360

catcctatga gactaattga gccagggtct cttatctgac ttcaagtgaa ccaccatttt    420

ggtggttttg atcttttgtc actgagccca aagagccagg gattaggaat taagatcgtg    480

cacaaaagtt tccttaaaat tcctggatgg ctgcagatgt tgggggaaaa agtacgtgat    540

attttagaaa cttagtggga aaagtaggat ggtattttta tgtaaagcct tgacccaatg    600

tttaaaaata taattgtatt tagatcttgt tattgctcca gtacatagga attgtgtaaa    660

gtgttaacag cagctgtatt tgtttaaatt gtgtgtattg aagattagga aaaagatagt    720

agttattttt cctaaatgaa ataactttct tctcttcccc ttccccaccc gaattctttt    780

ctgaagttgc tggcatttgg gtcaaggttt tattaaaagc tacattttat aacactggca    840

cacacaaaaa agtagtttta agcttgtttg cacagttctt tttttccatt ggaaatggaa    900

ttcattgcct taggtctttt taaatagtgt attattatcg ttggggctgg ctctatgctt    960

gaaaaccagt ttatttataa cctgttataa gtgctatatt ctgtttgcag ttaggaaatg   1020

cagaattcaa agtgatctcc tagcttgtaa gcaaactgag atgcactatc ccttttctat   1080

aaaaaataag ttaatgtgtc aagaaaccaa ctctattaag gtggggttta atattaccct   1140

ttcctatgtg ttttatctaa ttattttggt tgttaatatg gtgataatgg aaagtcaagt   1200

taaattttaa atattaagaa ttctgattta ttgagattga attatgccac cacgtttatg   1260

taaaaatgaa ggtggcaccg tggtgagacc taatgagaaa tagttactca gttgtaaaaa   1320

ttttgattta ttctctttct tctgacctcc ttgcctcttg tcttgaacca tagcaaaagg   1380

atactgcatc tctcattact gtagtgctga ggttattgaa gttatacaaa acacatctca   1440

gtctctgttt cttggaaagg tatctattac atcctgctag ctgactgaca aaactaagca   1500

gggagaataa agataattgt attttatgtt ttgcacacaa acgcagaatt tgtataacca   1560

tatgacttca tagttgtgat ctcaaaaaag aaggaatttc tcctttgttt cttgcagtta   1620

atgtaagaat actttaaatc tctaagcttc tgaagtgtta gaggtagaga tggtctagta   1680

aagatgtagt agtaatgttt tatccattta gcatgtgttt attttttcat atgtactcaa   1740

aggtgactta ttggttcacc tcagtgatat tacagctaaa aaaatcattc attagcaaaa   1800

ggaaaagtgg tctcaaccta acatcagaag tgtttcttat tattatttta tattgagttg   1860

aatattgaac tctaacagtt ttctacatac aaaacacagt gtcatgaagg ttattcataa   1920

ttgcattata gaggaatgta gtatgtcata agtactttgt aaagatttga cattcaactg   1980

tagtatccat atgttgctta aatttcctta tgagccccat gatggaaaga cttaaagatg   2040

aatttgagaa aaattgaaag aaattagatt atcaggttct gttaaattgt tacatgtatc   2100

ttgcttaaat ttctgtttat taatttatat ccacccaagt acataaagca aatttggagg   2160

aaacaactga agttgtgcaa tattttctga taattgcttt ttttattctt gtgttttcta   2220

cttaaacata atgtctgtgt catcaagtat tatagtcaga cttttctttt tttctagatt   2280

gttaaaattg gcaaatgaac ttttttaaaa atc                                2313


<210>  6282
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6282

Met Phe Tyr Pro Phe Ser Met Cys Leu Phe Phe His Met Tyr Ser Lys 
1               5                   10                  15      


Val Thr Tyr Trp Phe Thr Ser Val Ile Leu Gln Leu Lys Lys Ser Phe 
            20                  25                  30          


Ile Ser Lys Arg Lys Ser Gly Leu Asn Leu Thr Ser Glu Val Phe Leu 
        35                  40                  45              


Ile Ile Ile Leu Tyr 
    50              


<210>  6283
<211>  2509
<212>  DNA
<213>  Homosapiens

<400>  6283
aaaaaataat ctttttcctc tatattttaa tattttagga acaagttcca gttccagtct     60

accacccaac acctagccag actcggctag caactcagct gactgaagag gaacaaatta    120

ggatagctca aagaataggt cttatacaac atctgcctaa aggagtttat gaccctggaa    180

gagatggatc agaaaaaaag atccgggagt gtgtgatctg tatgatggac tttgtttatg    240

gggacccaat tcgatttctg ccgtgcatgc acatctatca cctggactgt atagatgact    300

ggttgatgag atccttcacg tgcccctcct gcatggagcc agttgatgca gcactgcttt    360

catcctatga gactaattga gccagggtct cttatctgac ttcaagtgaa ccaccatttt    420

ggtggttttg atcttttgtc actgagccca aagagccagg gattaggaat taagatcgtg    480

cacaaaagtt tccttaaaat tcctggatgg ctgcagatgt tgggggaaaa agtacgtgat    540

attttagaaa cttagtggga aaagtaggat ggtattttta tgtaaagcct tgacccaatg    600

tttaaaaata taattgtatt tagatcttgt tattgctcca gtacatagga attgtgtaaa    660

gtgttaacag cagctgtatt tgtttaaatt gtgtgtattg aagattagga aaaagatagt    720

agttattttt cctaaatgaa ataactttct tctcttcccc ttccccaccc gaattctttt    780

ctgaagttgc tggcatttgg gtcaaggttt tattaaaagc tacattttat aacactggca    840

cacacaaaaa agtagtttta agcttgtttg cacagttctt tttttccatt ggaaatggaa    900

ttcattgcct taggtctttt taaatagtgt attattatcg ttggggctgg ctctatgctt    960

gaaaaccagt ttatttataa cctgttataa gtgctatatt ctgtttgcag ttaggaaatg   1020

cagaattcaa agtgatctcc tagcttgtaa gcaaactgag atgcactatc ccttttctat   1080

aaaaaataag ttaatgtgtc aagaaaccaa ctctattaag gtggggttta atattaccct   1140

ttcctatgtg ttttatctaa ttattttggt tgttaatatg gtgataatgg aaagtcaagt   1200

taaattttaa atattaagaa ttctgattta ttgagattga attatgccac cacgtttatg   1260

taaaaatgaa ggtggcaccg tggtgagacc taatgagaaa tagttactca gttgtaaaaa   1320

ttttgattta ttctctttct tctgacctcc ttgcctcttg tcttgaacca tagcaaaagg   1380

atactgcatc tctcattact gtagtgctga ggttattgaa gttatacaaa acacatctca   1440

gtctctgttt cttggaaagg tatctattac atcctgctag ctgactgaca aaactaagca   1500

gggagaataa agataattgt attttatgtt ttgcacacaa acgcagaatt tgtataacca   1560

tatgacttca tagttgtgat ctcaaaaaag aaggaatttc tcctttgttt cttgcagtta   1620

atgtaagaat actttaaatc tctaagcttc tgaagtgtta gaggtagaga tggtctagta   1680

aagatgtagt agtaatgttt tatccattta gcatgtgttt attttttcat atgtactcaa   1740

aggtgactta ttggttcacc tcagtgatat tacagctaaa aaaatcattc attagcaaaa   1800

ggaaaagtgg tctcaaccta acatcagaag tgtttcttat tattatttta tattgagttg   1860

aatattgaac tctaacagtt ttctacatac aaaacacagt gtcatgaagg ttattcataa   1920

ttgcattata gaggaatgta gtatgtcata agtactttgt aaagatttga cattcaactg   1980

tagtatccat atgttgctta aatttcctta tgagccccat gatggaaaga cttaaagatg   2040

aatttgagaa aaattgaaag aaattagatt atcaggttct gttaaattgt tacatgtatc   2100

ttgcttaaat ttctgtttat taatttatat ccacccaagt acataaagca aatttggagg   2160

aaacaactga agttgtgcaa tattttctga taattgcttt ttttattctt gtgttttcta   2220

cttaaacata atgtctgtgt catcaagtat tatagtcaga cttttctttt tttctagatt   2280

gttaaaattg gcaaatgaac ttttttaaaa atcatcttcc atgttgcagt tagtctttct   2340

tttcattaca agtctttcac agaagtttgg tggtaatatt gaaagaacta gcattgggca   2400

gaatgtgtct tttttaggca ctttatattc tcaacataca atgttaagaa ccatcaattt   2460

tgacttttac taagttgtta aataaagtta taatacagct gtgaagggc               2509


<210>  6284
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6284

Met Phe Tyr Pro Phe Ser Met Cys Leu Phe Phe His Met Tyr Ser Lys 
1               5                   10                  15      


Val Thr Tyr Trp Phe Thr Ser Val Ile Leu Gln Leu Lys Lys Ser Phe 
            20                  25                  30          


Ile Ser Lys Arg Lys Ser Gly Leu Asn Leu Thr Ser Glu Val Phe Leu 
        35                  40                  45              


Ile Ile Ile Leu Tyr 
    50              


<210>  6285
<211>  2597
<212>  DNA
<213>  Homosapiens

<400>  6285
aaaaaataat ctttttcctc tatattttaa tattttagga acaagttcca gttccagtct     60

accacccaac acctagccag actcggctag caactcagct gactgaagag gaacaaatta    120

ggatagctca aagaataggt cttatacaac atctgcctaa aggagtttat gaccctggaa    180

gagatggatc agaaaaaaag atccgggagt gtgtgatctg tatgatggac tttgtttatg    240

gggacccaat tcgatttctg ccgtgcatgc acatctatca cctggactgt atagatgact    300

ggttgatgag atccttcacg tgcccctcct gcatggagcc agttgatgca gcactgcttt    360

catcctatga gactaattga gccagggtct cttatctgac ttcaagtgaa ccaccatttt    420

ggtggttttg atcttttgtc actgagccca aagagccagg gattaggaat taagatcgtg    480

cacaaaagtt tccttaaaat tcctggatgg ctgcagatgt tgggggaaaa agtacgtgat    540

attttagaaa cttagtggga aaagtaggat ggtattttta tgtaaagcct tgacccaatg    600

tttaaaaata taattgtatt tagatcttgt tattgctcca gtacatagga attgtgtaaa    660

gtgttaacag cagctgtatt tgtttaaatt gtgtgtattg aagattagga aaaagatagt    720

agttattttt cctaaatgaa ataactttct tctcttcccc ttccccaccc gaattctttt    780

ctgaagttgc tggcatttgg gtcaaggttt tattaaaagc tacattttat aacactggca    840

cacacaaaaa agtagtttta agcttgtttg cacagttctt tttttccatt ggaaatggaa    900

ttcattgcct taggtctttt taaatagtgt attattatcg ttggggctgg ctctatgctt    960

gaaaaccagt ttatttataa cctgttataa gtgctatatt ctgtttgcag ttaggaaatg   1020

cagaattcaa agtgatctcc tagcttgtaa gcaaactgag atgcactatc ccttttctat   1080

aaaaaataag ttaatgtgtc aagaaaccaa ctctattaag gtggggttta atattaccct   1140

ttcctatgtg ttttatctaa ttattttggt tgttaatatg gtgataatgg aaagtcaagt   1200

taaattttaa atattaagaa ttctgattta ttgagattga attatgccac cacgtttatg   1260

taaaaatgaa ggtggcaccg tggtgagacc taatgagaaa tagttactca gttgtaaaaa   1320

ttttgattta ttctctttct tctgacctcc ttgcctcttg tcttgaacca tagcaaaagg   1380

atactgcatc tctcattact gtagtgctga ggttattgaa gttatacaaa acacatctca   1440

gtctctgttt cttggaaagg tatctattac atcctgctag ctgactgaca aaactaagca   1500

gggagaataa agataattgt attttatgtt ttgcacacaa acgcagaatt tgtataacca   1560

tatgacttca tagttgtgat ctcaaaaaag aaggaatttc tcctttgttt cttgcagtta   1620

atgtaagaat actttaaatc tctaagcttc tgaagtgtta gaggtagaga tggtctagta   1680

aagatgtagt agtaatgttt tatccattta gcatgtgttt attttttcat atgtactcaa   1740

aggtgactta ttggttcacc tcagtgatat tacagctaaa aaaatcattc attagcaaaa   1800

ggaaaagtgg tctcaaccta acatcagaag tgtttcttat tattatttta tattgagttg   1860

aatattgaac tctaacagtt ttctacatac aaaacacagt gtcatgaagg ttattcataa   1920

ttgcattata gaggaatgta gtatgtcata agtactttgt aaagatttga cattcaactg   1980

tagtatccat atgttgctta aatttcctta tgagccccat gatggaaaga cttaaagatg   2040

aatttgagaa aaattgaaag aaattagatt atcaggttct gttaaattgt tacatgtatc   2100

ttgcttaaat ttctgtttat taatttatat ccacccaagt acataaagca aatttggagg   2160

aaacaactga agttgtgcaa tattttctga taattgcttt ttttattctt gtgttttcta   2220

cttaaacata atgtctgtgt catcaagtat tatagtcaga cttttctttt tttctagatt   2280

gttaaaattg gcaaatgaac ttttttaaaa atcatcttcc atgttgcagt tagtctttct   2340

tttcattaca agtctttcac agaagtttgg tggtaatatt gaaagaacta gcattgggca   2400

gaatgtgtct tttttaggca ctttatattc tcaacataca atgttaagaa ccatcaattt   2460

tgacttttac taagttgtta aataaagtta taatacagct gtgaagggct aaagttagag   2520

ttgattacat aagtaagtat tccccatata atcttttaaa aagttgtgta tgattatttt   2580

aaaatctctc tctctat                                                  2597


<210>  6286
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6286

Met Phe Tyr Pro Phe Ser Met Cys Leu Phe Phe His Met Tyr Ser Lys 
1               5                   10                  15      


Val Thr Tyr Trp Phe Thr Ser Val Ile Leu Gln Leu Lys Lys Ser Phe 
            20                  25                  30          


Ile Ser Lys Arg Lys Ser Gly Leu Asn Leu Thr Ser Glu Val Phe Leu 
        35                  40                  45              


Ile Ile Ile Leu Tyr 
    50              


<210>  6287
<211>  1715
<212>  DNA
<213>  Homosapiens

<400>  6287
agccaggatt aggaattaag atcgtgcaca aaagtttcct taaaattcct ggatggctgc     60

agatgttggg ggaaaaagta cgtgatattt tagaaactta gtgggaaaag taggatggta    120

tttttatgta aagccttgac ccaatgttta aaaatataat tgtatttaga tcttgttatt    180

gctccagtac ataggaattg tgtaaagtgt taacagcagc tgtatttgtt taaattgtgt    240

gtattgaaga ttaggaaaaa gatagtagtt atttttccta aatgaaataa ctttcttctc    300

ttccccttcc ccacccgaat tcttttctga agttgctggc atttgggtca aggttttatt    360

aaaagctaca ttttataaca ctggcacaca caaaaaagta gttttaagct tgtttgcaca    420

gttctttttt tccattggaa atggaattca ttgccttagg tctttttaaa tagtgtatta    480

ttatcgttgg ggctggctct atgcttgaaa accagtttat ttataacctg ttataagtgc    540

tatattctgt ttgcagttag gaaatgcaga attcaaagtg atctcctagc ttgtaagcaa    600

actgagatgc actatccctt ttctataaaa aataagttaa tgtgtcaaga aaccaactct    660

attaaggtgg ggtttaatat taccctttcc tatgtgtttt atctaattat tttggttgtt    720

aatatggtga taatggaaag tcaagttaaa ttttaaatat taagaattct gatttattga    780

gattgaatta tgccaccacg tttatgtaaa aatgaaggtg gcaccgtggt gagacctaat    840

gagaaatagt tactcagttg taaaaatttt gatttattct ctttcttctg acctccttgc    900

ctcttgtctt gaaccatagc aaaaggatac tgcatctctc attactgtag tgctgaggtt    960

attgaagtta tacaaaacac atctcagtct ctgtttcttg gaaaggtatc tattacatcc   1020

tgctagctga ctgacaaaac taagcaggga gaataaagat aattgtattt tatgttttgc   1080

acacaaacgc agaatttgta taaccatatg acttcatagt tgtgatctca aaaaagaagg   1140

aatttctcct ttgtttcttg cagttaatgt aagaatactt taaatctcta agcttctgaa   1200

gtgttagagg tagagatggt ctagtaaaga tgtagtagta atgttttatc catttagcat   1260

gtgtttattt tttcatatgt actcaaaggt gacttattgg ttcacctcag tgatattaca   1320

gctaaaaaaa tcattcatta gcaaaaggaa aagtggtctc aacctaacat cagaagtgtt   1380

tcttattatt attttatatt gagttgaata ttgaactcta acagttttct acatacaaaa   1440

cacagtgtca tgaaggttat tcataattgc attatagagg aatgtagtat gtcataagta   1500

ctttgtaaag atttgacatt caactgtagt atccatatgt tgcttaaatt tccttatgag   1560

ccccatgatg gaaagactta aagatgaatt tgagaaaaat tgaaagaaat tagattatca   1620

ggttctgtta aattgttaca tgtatcttgc ttaaatttct gtttattaat ttatatccac   1680

ccaagtacat aaagcaaatt tggaggaaac aactg                              1715


<210>  6288
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6288

Met Phe Tyr Pro Phe Ser Met Cys Leu Phe Phe His Met Tyr Ser Lys 
1               5                   10                  15      


Val Thr Tyr Trp Phe Thr Ser Val Ile Leu Gln Leu Lys Lys Ser Phe 
            20                  25                  30          


Ile Ser Lys Arg Lys Ser Gly Leu Asn Leu Thr Ser Glu Val Phe Leu 
        35                  40                  45              


Ile Ile Ile Leu Tyr 
    50              


<210>  6289
<211>  1789
<212>  DNA
<213>  Homosapiens

<400>  6289
agccaggtct cttatctgac ttcaagtgaa ccaccatttt ggtggttttg atcttttgtc     60

actgagccca aagagccagg gattaggaat taagatcgtg cacaaaagtt tccttaaaat    120

tcctggatgg ctgcagatgt tgggggaaaa agtacgtgat attttagaaa cttagtggga    180

aaagtaggat ggtattttta tgtaaagcct tgacccaatg tttaaaaata taattgtatt    240

tagatcttgt tattgctcca gtacatagga attgtgtaaa gtgttaacag cagctgtatt    300

tgtttaaatt gtgtgtattg aagattagga aaaagatagt agttattttt cctaaatgaa    360

ataactttct tctcttcccc ttccccaccc gaattctttt ctgaagttgc tggcatttgg    420

gtcaaggttt tattaaaagc tacattttat aacactggca cacacaaaaa agtagtttta    480

agcttgtttg cacagttctt tttttccatt ggaaatggaa ttcattgcct taggtctttt    540

taaatagtgt attattatcg ttggggctgg ctctatgctt gaaaaccagt ttatttataa    600

cctgttataa gtgctatatt ctgtttgcag ttaggaaatg cagaattcaa agtgatctcc    660

tagcttgtaa gcaaactgag atgcactatc ccttttctat aaaaaataag ttaatgtgtc    720

aagaaaccaa ctctattaag gtggggttta atattaccct ttcctatgtg ttttatctaa    780

ttattttggt tgttaatatg gtgataatgg aaagtcaagt taaattttaa atattaagaa    840

ttctgattta ttgagattga attatgccac cacgtttatg taaaaatgaa ggtggcaccg    900

tggtgagacc taatgagaaa tagttactca gttgtaaaaa ttttgattta ttctctttct    960

tctgacctcc ttgcctcttg tcttgaacca tagcaaaagg atactgcatc tctcattact   1020

gtagtgctga ggttattgaa gttatacaaa acacatctca gtctctgttt cttggaaagg   1080

tatctattac atcctgctag ctgactgaca aaactaagca gggagaataa agataattgt   1140

attttatgtt ttgcacacaa acgcagaatt tgtataacca tatgacttca tagttgtgat   1200

ctcaaaaaag aaggaatttc tcctttgttt cttgcagtta atgtaagaat actttaaatc   1260

tctaagcttc tgaagtgtta gaggtagaga tggtctagta aagatgtagt agtaatgttt   1320

tatccattta gcatgtgttt attttttcat atgtactcaa aggtgactta ttggttcacc   1380

tcagtgatat tacagctaaa aaaatcattc attagcaaaa ggaaaagtgg tctcaaccta   1440

acatcagaag tgtttcttat tattatttta tattgagttg aatattgaac tctaacagtt   1500

ttctacatac aaaacacagt gtcatgaagg ttattcataa ttgcattata gaggaatgta   1560

gtatgtcata agtactttgt aaagatttga cattcaactg tagtatccat atgttgctta   1620

aatttcctta tgagccccat gatggaaaga cttaaagatg aatttgagaa aaattgaaag   1680

aaattagatt atcaggttct gttaaattgt tacatgtatc ttgcttaaat ttctgtttat   1740

taatttatat ccacccaagt acataaagca aatttggagg aaacaactg               1789


<210>  6290
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6290

Met Phe Tyr Pro Phe Ser Met Cys Leu Phe Phe His Met Tyr Ser Lys 
1               5                   10                  15      


Val Thr Tyr Trp Phe Thr Ser Val Ile Leu Gln Leu Lys Lys Ser Phe 
            20                  25                  30          


Ile Ser Lys Arg Lys Ser Gly Leu Asn Leu Thr Ser Glu Val Phe Leu 
        35                  40                  45              


Ile Ile Ile Leu Tyr 
    50              


<210>  6291
<211>  1859
<212>  DNA
<213>  Homosapiens

<400>  6291
agccaggatt aggaattaag atcgtgcaca aaagtttcct taaaattcct ggatggctgc     60

agatgttggg ggaaaaagta cgtgatattt tagaaactta gtgggaaaag taggatggta    120

tttttatgta aagccttgac ccaatgttta aaaatataat tgtatttaga tcttgttatt    180

gctccagtac ataggaattg tgtaaagtgt taacagcagc tgtatttgtt taaattgtgt    240

gtattgaaga ttaggaaaaa gatagtagtt atttttccta aatgaaataa ctttcttctc    300

ttccccttcc ccacccgaat tcttttctga agttgctggc atttgggtca aggttttatt    360

aaaagctaca ttttataaca ctggcacaca caaaaaagta gttttaagct tgtttgcaca    420

gttctttttt tccattggaa atggaattca ttgccttagg tctttttaaa tagtgtatta    480

ttatcgttgg ggctggctct atgcttgaaa accagtttat ttataacctg ttataagtgc    540

tatattctgt ttgcagttag gaaatgcaga attcaaagtg atctcctagc ttgtaagcaa    600

actgagatgc actatccctt ttctataaaa aataagttaa tgtgtcaaga aaccaactct    660

attaaggtgg ggtttaatat taccctttcc tatgtgtttt atctaattat tttggttgtt    720

aatatggtga taatggaaag tcaagttaaa ttttaaatat taagaattct gatttattga    780

gattgaatta tgccaccacg tttatgtaaa aatgaaggtg gcaccgtggt gagacctaat    840

gagaaatagt tactcagttg taaaaatttt gatttattct ctttcttctg acctccttgc    900

ctcttgtctt gaaccatagc aaaaggatac tgcatctctc attactgtag tgctgaggtt    960

attgaagtta tacaaaacac atctcagtct ctgtttcttg gaaaggtatc tattacatcc   1020

tgctagctga ctgacaaaac taagcaggga gaataaagat aattgtattt tatgttttgc   1080

acacaaacgc agaatttgta taaccatatg acttcatagt tgtgatctca aaaaagaagg   1140

aatttctcct ttgtttcttg cagttaatgt aagaatactt taaatctcta agcttctgaa   1200

gtgttagagg tagagatggt ctagtaaaga tgtagtagta atgttttatc catttagcat   1260

gtgtttattt tttcatatgt actcaaaggt gacttattgg ttcacctcag tgatattaca   1320

gctaaaaaaa tcattcatta gcaaaaggaa aagtggtctc aacctaacat cagaagtgtt   1380

tcttattatt attttatatt gagttgaata ttgaactcta acagttttct acatacaaaa   1440

cacagtgtca tgaaggttat tcataattgc attatagagg aatgtagtat gtcataagta   1500

ctttgtaaag atttgacatt caactgtagt atccatatgt tgcttaaatt tccttatgag   1560

ccccatgatg gaaagactta aagatgaatt tgagaaaaat tgaaagaaat tagattatca   1620

ggttctgtta aattgttaca tgtatcttgc ttaaatttct gtttattaat ttatatccac   1680

ccaagtacat aaagcaaatt tggaggaaac aactgaagtt gtgcaatatt ttctgataat   1740

tgcttttttt attcttgtgt tttctactta aacataatgt ctgtgtcatc aagtattata   1800

gtcagacttt tctttttttc tagattgtta aaattggcaa atgaactttt ttaaaaatc    1859


<210>  6292
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6292

Met Phe Tyr Pro Phe Ser Met Cys Leu Phe Phe His Met Tyr Ser Lys 
1               5                   10                  15      


Val Thr Tyr Trp Phe Thr Ser Val Ile Leu Gln Leu Lys Lys Ser Phe 
            20                  25                  30          


Ile Ser Lys Arg Lys Ser Gly Leu Asn Leu Thr Ser Glu Val Phe Leu 
        35                  40                  45              


Ile Ile Ile Leu Tyr 
    50              


<210>  6293
<211>  1933
<212>  DNA
<213>  Homosapiens

<400>  6293
agccaggtct cttatctgac ttcaagtgaa ccaccatttt ggtggttttg atcttttgtc     60

actgagccca aagagccagg gattaggaat taagatcgtg cacaaaagtt tccttaaaat    120

tcctggatgg ctgcagatgt tgggggaaaa agtacgtgat attttagaaa cttagtggga    180

aaagtaggat ggtattttta tgtaaagcct tgacccaatg tttaaaaata taattgtatt    240

tagatcttgt tattgctcca gtacatagga attgtgtaaa gtgttaacag cagctgtatt    300

tgtttaaatt gtgtgtattg aagattagga aaaagatagt agttattttt cctaaatgaa    360

ataactttct tctcttcccc ttccccaccc gaattctttt ctgaagttgc tggcatttgg    420

gtcaaggttt tattaaaagc tacattttat aacactggca cacacaaaaa agtagtttta    480

agcttgtttg cacagttctt tttttccatt ggaaatggaa ttcattgcct taggtctttt    540

taaatagtgt attattatcg ttggggctgg ctctatgctt gaaaaccagt ttatttataa    600

cctgttataa gtgctatatt ctgtttgcag ttaggaaatg cagaattcaa agtgatctcc    660

tagcttgtaa gcaaactgag atgcactatc ccttttctat aaaaaataag ttaatgtgtc    720

aagaaaccaa ctctattaag gtggggttta atattaccct ttcctatgtg ttttatctaa    780

ttattttggt tgttaatatg gtgataatgg aaagtcaagt taaattttaa atattaagaa    840

ttctgattta ttgagattga attatgccac cacgtttatg taaaaatgaa ggtggcaccg    900

tggtgagacc taatgagaaa tagttactca gttgtaaaaa ttttgattta ttctctttct    960

tctgacctcc ttgcctcttg tcttgaacca tagcaaaagg atactgcatc tctcattact   1020

gtagtgctga ggttattgaa gttatacaaa acacatctca gtctctgttt cttggaaagg   1080

tatctattac atcctgctag ctgactgaca aaactaagca gggagaataa agataattgt   1140

attttatgtt ttgcacacaa acgcagaatt tgtataacca tatgacttca tagttgtgat   1200

ctcaaaaaag aaggaatttc tcctttgttt cttgcagtta atgtaagaat actttaaatc   1260

tctaagcttc tgaagtgtta gaggtagaga tggtctagta aagatgtagt agtaatgttt   1320

tatccattta gcatgtgttt attttttcat atgtactcaa aggtgactta ttggttcacc   1380

tcagtgatat tacagctaaa aaaatcattc attagcaaaa ggaaaagtgg tctcaaccta   1440

acatcagaag tgtttcttat tattatttta tattgagttg aatattgaac tctaacagtt   1500

ttctacatac aaaacacagt gtcatgaagg ttattcataa ttgcattata gaggaatgta   1560

gtatgtcata agtactttgt aaagatttga cattcaactg tagtatccat atgttgctta   1620

aatttcctta tgagccccat gatggaaaga cttaaagatg aatttgagaa aaattgaaag   1680

aaattagatt atcaggttct gttaaattgt tacatgtatc ttgcttaaat ttctgtttat   1740

taatttatat ccacccaagt acataaagca aatttggagg aaacaactga agttgtgcaa   1800

tattttctga taattgcttt ttttattctt gtgttttcta cttaaacata atgtctgtgt   1860

catcaagtat tatagtcaga cttttctttt tttctagatt gttaaaattg gcaaatgaac   1920

ttttttaaaa atc                                                      1933


<210>  6294
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6294

Met Phe Tyr Pro Phe Ser Met Cys Leu Phe Phe His Met Tyr Ser Lys 
1               5                   10                  15      


Val Thr Tyr Trp Phe Thr Ser Val Ile Leu Gln Leu Lys Lys Ser Phe 
            20                  25                  30          


Ile Ser Lys Arg Lys Ser Gly Leu Asn Leu Thr Ser Glu Val Phe Leu 
        35                  40                  45              


Ile Ile Ile Leu Tyr 
    50              


<210>  6295
<211>  2055
<212>  DNA
<213>  Homosapiens

<400>  6295
agccaggatt aggaattaag atcgtgcaca aaagtttcct taaaattcct ggatggctgc     60

agatgttggg ggaaaaagta cgtgatattt tagaaactta gtgggaaaag taggatggta    120

tttttatgta aagccttgac ccaatgttta aaaatataat tgtatttaga tcttgttatt    180

gctccagtac ataggaattg tgtaaagtgt taacagcagc tgtatttgtt taaattgtgt    240

gtattgaaga ttaggaaaaa gatagtagtt atttttccta aatgaaataa ctttcttctc    300

ttccccttcc ccacccgaat tcttttctga agttgctggc atttgggtca aggttttatt    360

aaaagctaca ttttataaca ctggcacaca caaaaaagta gttttaagct tgtttgcaca    420

gttctttttt tccattggaa atggaattca ttgccttagg tctttttaaa tagtgtatta    480

ttatcgttgg ggctggctct atgcttgaaa accagtttat ttataacctg ttataagtgc    540

tatattctgt ttgcagttag gaaatgcaga attcaaagtg atctcctagc ttgtaagcaa    600

actgagatgc actatccctt ttctataaaa aataagttaa tgtgtcaaga aaccaactct    660

attaaggtgg ggtttaatat taccctttcc tatgtgtttt atctaattat tttggttgtt    720

aatatggtga taatggaaag tcaagttaaa ttttaaatat taagaattct gatttattga    780

gattgaatta tgccaccacg tttatgtaaa aatgaaggtg gcaccgtggt gagacctaat    840

gagaaatagt tactcagttg taaaaatttt gatttattct ctttcttctg acctccttgc    900

ctcttgtctt gaaccatagc aaaaggatac tgcatctctc attactgtag tgctgaggtt    960

attgaagtta tacaaaacac atctcagtct ctgtttcttg gaaaggtatc tattacatcc   1020

tgctagctga ctgacaaaac taagcaggga gaataaagat aattgtattt tatgttttgc   1080

acacaaacgc agaatttgta taaccatatg acttcatagt tgtgatctca aaaaagaagg   1140

aatttctcct ttgtttcttg cagttaatgt aagaatactt taaatctcta agcttctgaa   1200

gtgttagagg tagagatggt ctagtaaaga tgtagtagta atgttttatc catttagcat   1260

gtgtttattt tttcatatgt actcaaaggt gacttattgg ttcacctcag tgatattaca   1320

gctaaaaaaa tcattcatta gcaaaaggaa aagtggtctc aacctaacat cagaagtgtt   1380

tcttattatt attttatatt gagttgaata ttgaactcta acagttttct acatacaaaa   1440

cacagtgtca tgaaggttat tcataattgc attatagagg aatgtagtat gtcataagta   1500

ctttgtaaag atttgacatt caactgtagt atccatatgt tgcttaaatt tccttatgag   1560

ccccatgatg gaaagactta aagatgaatt tgagaaaaat tgaaagaaat tagattatca   1620

ggttctgtta aattgttaca tgtatcttgc ttaaatttct gtttattaat ttatatccac   1680

ccaagtacat aaagcaaatt tggaggaaac aactgaagtt gtgcaatatt ttctgataat   1740

tgcttttttt attcttgtgt tttctactta aacataatgt ctgtgtcatc aagtattata   1800

gtcagacttt tctttttttc tagattgtta aaattggcaa atgaactttt ttaaaaatca   1860

tcttccatgt tgcagttagt ctttcttttc attacaagtc tttcacagaa gtttggtggt   1920

aatattgaaa gaactagcat tgggcagaat gtgtcttttt taggcacttt atattctcaa   1980

catacaatgt taagaaccat caattttgac ttttactaag ttgttaaata aagttataat   2040

acagctgtga agggc                                                    2055


<210>  6296
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6296

Met Phe Tyr Pro Phe Ser Met Cys Leu Phe Phe His Met Tyr Ser Lys 
1               5                   10                  15      


Val Thr Tyr Trp Phe Thr Ser Val Ile Leu Gln Leu Lys Lys Ser Phe 
            20                  25                  30          


Ile Ser Lys Arg Lys Ser Gly Leu Asn Leu Thr Ser Glu Val Phe Leu 
        35                  40                  45              


Ile Ile Ile Leu Tyr 
    50              


<210>  6297
<211>  2129
<212>  DNA
<213>  Homosapiens

<400>  6297
agccaggtct cttatctgac ttcaagtgaa ccaccatttt ggtggttttg atcttttgtc     60

actgagccca aagagccagg gattaggaat taagatcgtg cacaaaagtt tccttaaaat    120

tcctggatgg ctgcagatgt tgggggaaaa agtacgtgat attttagaaa cttagtggga    180

aaagtaggat ggtattttta tgtaaagcct tgacccaatg tttaaaaata taattgtatt    240

tagatcttgt tattgctcca gtacatagga attgtgtaaa gtgttaacag cagctgtatt    300

tgtttaaatt gtgtgtattg aagattagga aaaagatagt agttattttt cctaaatgaa    360

ataactttct tctcttcccc ttccccaccc gaattctttt ctgaagttgc tggcatttgg    420

gtcaaggttt tattaaaagc tacattttat aacactggca cacacaaaaa agtagtttta    480

agcttgtttg cacagttctt tttttccatt ggaaatggaa ttcattgcct taggtctttt    540

taaatagtgt attattatcg ttggggctgg ctctatgctt gaaaaccagt ttatttataa    600

cctgttataa gtgctatatt ctgtttgcag ttaggaaatg cagaattcaa agtgatctcc    660

tagcttgtaa gcaaactgag atgcactatc ccttttctat aaaaaataag ttaatgtgtc    720

aagaaaccaa ctctattaag gtggggttta atattaccct ttcctatgtg ttttatctaa    780

ttattttggt tgttaatatg gtgataatgg aaagtcaagt taaattttaa atattaagaa    840

ttctgattta ttgagattga attatgccac cacgtttatg taaaaatgaa ggtggcaccg    900

tggtgagacc taatgagaaa tagttactca gttgtaaaaa ttttgattta ttctctttct    960

tctgacctcc ttgcctcttg tcttgaacca tagcaaaagg atactgcatc tctcattact   1020

gtagtgctga ggttattgaa gttatacaaa acacatctca gtctctgttt cttggaaagg   1080

tatctattac atcctgctag ctgactgaca aaactaagca gggagaataa agataattgt   1140

attttatgtt ttgcacacaa acgcagaatt tgtataacca tatgacttca tagttgtgat   1200

ctcaaaaaag aaggaatttc tcctttgttt cttgcagtta atgtaagaat actttaaatc   1260

tctaagcttc tgaagtgtta gaggtagaga tggtctagta aagatgtagt agtaatgttt   1320

tatccattta gcatgtgttt attttttcat atgtactcaa aggtgactta ttggttcacc   1380

tcagtgatat tacagctaaa aaaatcattc attagcaaaa ggaaaagtgg tctcaaccta   1440

acatcagaag tgtttcttat tattatttta tattgagttg aatattgaac tctaacagtt   1500

ttctacatac aaaacacagt gtcatgaagg ttattcataa ttgcattata gaggaatgta   1560

gtatgtcata agtactttgt aaagatttga cattcaactg tagtatccat atgttgctta   1620

aatttcctta tgagccccat gatggaaaga cttaaagatg aatttgagaa aaattgaaag   1680

aaattagatt atcaggttct gttaaattgt tacatgtatc ttgcttaaat ttctgtttat   1740

taatttatat ccacccaagt acataaagca aatttggagg aaacaactga agttgtgcaa   1800

tattttctga taattgcttt ttttattctt gtgttttcta cttaaacata atgtctgtgt   1860

catcaagtat tatagtcaga cttttctttt tttctagatt gttaaaattg gcaaatgaac   1920

ttttttaaaa atcatcttcc atgttgcagt tagtctttct tttcattaca agtctttcac   1980

agaagtttgg tggtaatatt gaaagaacta gcattgggca gaatgtgtct tttttaggca   2040

ctttatattc tcaacataca atgttaagaa ccatcaattt tgacttttac taagttgtta   2100

aataaagtta taatacagct gtgaagggc                                     2129


<210>  6298
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6298

Met Phe Tyr Pro Phe Ser Met Cys Leu Phe Phe His Met Tyr Ser Lys 
1               5                   10                  15      


Val Thr Tyr Trp Phe Thr Ser Val Ile Leu Gln Leu Lys Lys Ser Phe 
            20                  25                  30          


Ile Ser Lys Arg Lys Ser Gly Leu Asn Leu Thr Ser Glu Val Phe Leu 
        35                  40                  45              


Ile Ile Ile Leu Tyr 
    50              


<210>  6299
<211>  2143
<212>  DNA
<213>  Homosapiens

<400>  6299
agccaggatt aggaattaag atcgtgcaca aaagtttcct taaaattcct ggatggctgc     60

agatgttggg ggaaaaagta cgtgatattt tagaaactta gtgggaaaag taggatggta    120

tttttatgta aagccttgac ccaatgttta aaaatataat tgtatttaga tcttgttatt    180

gctccagtac ataggaattg tgtaaagtgt taacagcagc tgtatttgtt taaattgtgt    240

gtattgaaga ttaggaaaaa gatagtagtt atttttccta aatgaaataa ctttcttctc    300

ttccccttcc ccacccgaat tcttttctga agttgctggc atttgggtca aggttttatt    360

aaaagctaca ttttataaca ctggcacaca caaaaaagta gttttaagct tgtttgcaca    420

gttctttttt tccattggaa atggaattca ttgccttagg tctttttaaa tagtgtatta    480

ttatcgttgg ggctggctct atgcttgaaa accagtttat ttataacctg ttataagtgc    540

tatattctgt ttgcagttag gaaatgcaga attcaaagtg atctcctagc ttgtaagcaa    600

actgagatgc actatccctt ttctataaaa aataagttaa tgtgtcaaga aaccaactct    660

attaaggtgg ggtttaatat taccctttcc tatgtgtttt atctaattat tttggttgtt    720

aatatggtga taatggaaag tcaagttaaa ttttaaatat taagaattct gatttattga    780

gattgaatta tgccaccacg tttatgtaaa aatgaaggtg gcaccgtggt gagacctaat    840

gagaaatagt tactcagttg taaaaatttt gatttattct ctttcttctg acctccttgc    900

ctcttgtctt gaaccatagc aaaaggatac tgcatctctc attactgtag tgctgaggtt    960

attgaagtta tacaaaacac atctcagtct ctgtttcttg gaaaggtatc tattacatcc   1020

tgctagctga ctgacaaaac taagcaggga gaataaagat aattgtattt tatgttttgc   1080

acacaaacgc agaatttgta taaccatatg acttcatagt tgtgatctca aaaaagaagg   1140

aatttctcct ttgtttcttg cagttaatgt aagaatactt taaatctcta agcttctgaa   1200

gtgttagagg tagagatggt ctagtaaaga tgtagtagta atgttttatc catttagcat   1260

gtgtttattt tttcatatgt actcaaaggt gacttattgg ttcacctcag tgatattaca   1320

gctaaaaaaa tcattcatta gcaaaaggaa aagtggtctc aacctaacat cagaagtgtt   1380

tcttattatt attttatatt gagttgaata ttgaactcta acagttttct acatacaaaa   1440

cacagtgtca tgaaggttat tcataattgc attatagagg aatgtagtat gtcataagta   1500

ctttgtaaag atttgacatt caactgtagt atccatatgt tgcttaaatt tccttatgag   1560

ccccatgatg gaaagactta aagatgaatt tgagaaaaat tgaaagaaat tagattatca   1620

ggttctgtta aattgttaca tgtatcttgc ttaaatttct gtttattaat ttatatccac   1680

ccaagtacat aaagcaaatt tggaggaaac aactgaagtt gtgcaatatt ttctgataat   1740

tgcttttttt attcttgtgt tttctactta aacataatgt ctgtgtcatc aagtattata   1800

gtcagacttt tctttttttc tagattgtta aaattggcaa atgaactttt ttaaaaatca   1860

tcttccatgt tgcagttagt ctttcttttc attacaagtc tttcacagaa gtttggtggt   1920

aatattgaaa gaactagcat tgggcagaat gtgtcttttt taggcacttt atattctcaa   1980

catacaatgt taagaaccat caattttgac ttttactaag ttgttaaata aagttataat   2040

acagctgtga agggctaaag ttagagttga ttacataagt aagtattccc catataatct   2100

tttaaaaagt tgtgtatgat tattttaaaa tctctctctc tat                     2143


<210>  6300
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6300

Met Phe Tyr Pro Phe Ser Met Cys Leu Phe Phe His Met Tyr Ser Lys 
1               5                   10                  15      


Val Thr Tyr Trp Phe Thr Ser Val Ile Leu Gln Leu Lys Lys Ser Phe 
            20                  25                  30          


Ile Ser Lys Arg Lys Ser Gly Leu Asn Leu Thr Ser Glu Val Phe Leu 
        35                  40                  45              


Ile Ile Ile Leu Tyr 
    50              


<210>  6301
<211>  2217
<212>  DNA
<213>  Homosapiens

<400>  6301
agccaggtct cttatctgac ttcaagtgaa ccaccatttt ggtggttttg atcttttgtc     60

actgagccca aagagccagg gattaggaat taagatcgtg cacaaaagtt tccttaaaat    120

tcctggatgg ctgcagatgt tgggggaaaa agtacgtgat attttagaaa cttagtggga    180

aaagtaggat ggtattttta tgtaaagcct tgacccaatg tttaaaaata taattgtatt    240

tagatcttgt tattgctcca gtacatagga attgtgtaaa gtgttaacag cagctgtatt    300

tgtttaaatt gtgtgtattg aagattagga aaaagatagt agttattttt cctaaatgaa    360

ataactttct tctcttcccc ttccccaccc gaattctttt ctgaagttgc tggcatttgg    420

gtcaaggttt tattaaaagc tacattttat aacactggca cacacaaaaa agtagtttta    480

agcttgtttg cacagttctt tttttccatt ggaaatggaa ttcattgcct taggtctttt    540

taaatagtgt attattatcg ttggggctgg ctctatgctt gaaaaccagt ttatttataa    600

cctgttataa gtgctatatt ctgtttgcag ttaggaaatg cagaattcaa agtgatctcc    660

tagcttgtaa gcaaactgag atgcactatc ccttttctat aaaaaataag ttaatgtgtc    720

aagaaaccaa ctctattaag gtggggttta atattaccct ttcctatgtg ttttatctaa    780

ttattttggt tgttaatatg gtgataatgg aaagtcaagt taaattttaa atattaagaa    840

ttctgattta ttgagattga attatgccac cacgtttatg taaaaatgaa ggtggcaccg    900

tggtgagacc taatgagaaa tagttactca gttgtaaaaa ttttgattta ttctctttct    960

tctgacctcc ttgcctcttg tcttgaacca tagcaaaagg atactgcatc tctcattact   1020

gtagtgctga ggttattgaa gttatacaaa acacatctca gtctctgttt cttggaaagg   1080

tatctattac atcctgctag ctgactgaca aaactaagca gggagaataa agataattgt   1140

attttatgtt ttgcacacaa acgcagaatt tgtataacca tatgacttca tagttgtgat   1200

ctcaaaaaag aaggaatttc tcctttgttt cttgcagtta atgtaagaat actttaaatc   1260

tctaagcttc tgaagtgtta gaggtagaga tggtctagta aagatgtagt agtaatgttt   1320

tatccattta gcatgtgttt attttttcat atgtactcaa aggtgactta ttggttcacc   1380

tcagtgatat tacagctaaa aaaatcattc attagcaaaa ggaaaagtgg tctcaaccta   1440

acatcagaag tgtttcttat tattatttta tattgagttg aatattgaac tctaacagtt   1500

ttctacatac aaaacacagt gtcatgaagg ttattcataa ttgcattata gaggaatgta   1560

gtatgtcata agtactttgt aaagatttga cattcaactg tagtatccat atgttgctta   1620

aatttcctta tgagccccat gatggaaaga cttaaagatg aatttgagaa aaattgaaag   1680

aaattagatt atcaggttct gttaaattgt tacatgtatc ttgcttaaat ttctgtttat   1740

taatttatat ccacccaagt acataaagca aatttggagg aaacaactga agttgtgcaa   1800

tattttctga taattgcttt ttttattctt gtgttttcta cttaaacata atgtctgtgt   1860

catcaagtat tatagtcaga cttttctttt tttctagatt gttaaaattg gcaaatgaac   1920

ttttttaaaa atcatcttcc atgttgcagt tagtctttct tttcattaca agtctttcac   1980

agaagtttgg tggtaatatt gaaagaacta gcattgggca gaatgtgtct tttttaggca   2040

ctttatattc tcaacataca atgttaagaa ccatcaattt tgacttttac taagttgtta   2100

aataaagtta taatacagct gtgaagggct aaagttagag ttgattacat aagtaagtat   2160

tccccatata atcttttaaa aagttgtgta tgattatttt aaaatctctc tctctat      2217


<210>  6302
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6302

Met Phe Tyr Pro Phe Ser Met Cys Leu Phe Phe His Met Tyr Ser Lys 
1               5                   10                  15      


Val Thr Tyr Trp Phe Thr Ser Val Ile Leu Gln Leu Lys Lys Ser Phe 
            20                  25                  30          


Ile Ser Lys Arg Lys Ser Gly Leu Asn Leu Thr Ser Glu Val Phe Leu 
        35                  40                  45              


Ile Ile Ile Leu Tyr 
    50              


<210>  6303
<211>  1664
<212>  DNA
<213>  Homosapiens

<400>  6303
gagctgggca gggcacagca gggcaggagt gtgtttgatg tgtcctggga accgccctga     60

ggccgtcgtg tggctggagt gctgcaggtg tcaaggaaat tgtaggagat gtctcctgag    120

tgtgatggaa tataaccaga tttccagaag gaactgacat gatctgactt aaaaagagct    180

gtgccaggcc tgaagctcaa gattgctggg aaatctctac ccacagagaa gtttgccatc    240

cggaagtccc ggcgctactt ctcctccaac cctatctcgc tgccagtgcc tgctctggaa    300

atgatgtaca tctggaacgg ctacgccgtg attgggaagc agccgaaact cacggatggg    360

atacttgaga ttatcactaa ggctgaagag atgctggaga aaggcccaga gaacgagtac    420

tcagtggatg acgagtgctt ggtgaaattg ttgaaaggcc tgtgtctgaa atacctgggc    480

cgtgtccagg aggccgagga gaattttagg agcatctctg ccaatgaaaa gaagattaaa    540

tatgaccact acttgatccc aaacgccctg ctggagctgg ccctgctgct tatggagcaa    600

gacagaaacg aagaggccat caaacttttg gaatctgcca agcaaaacta caagaattac    660

tccatggagt caaggacaca ctttcgaatc caggcagcca cactccaagc caagtcttcc    720

ctagagaaca gcagcagatc catggtctca tcagtgtcct tgtagctttg tgcagcagtt    780

ccgggctgga agacagagac agctggacag agctcctgaa aacatttcaa aataccccct    840

ccccctgccc tgccctgcct ttggggtcca ccggcactcc agttggatgg cacaacatag    900

tgtatccgtg cagaagccga gctggcattt tcaccagtgt agccaagggc ctttgccaag    960

ggcagagcag gtggagccct ctgcctgccc tatcacacat acgggtactt gcttttcact   1020

gtgatgttta agagaatgta tgaacagttt acattttcct tagaaataca ttgatgggat   1080

cacagttggc tttaaaaacc aacaacaatc aaccacctgt aagtctttgt cttcacctat   1140

tatcatctgg aggtaaatct ctttatatga tgatgccaaa gggcaaattg cttttcaaat   1200

tcagcaagtt ctcagcttgt gtgacggaag gtccttcaga ggacctgagg aatgcctggg   1260

agaggctaag cctcaggctt caatgcttct ggggttgggc atgaggatgt acacagacac   1320

ccactacctt actactcaca cttcatttca ctccttttgt aaatttccaa tttaaaaatc   1380

aagcacgtct ttttagtgag ataaaatctg agctcttctg tagaaaaatc aatctctacc   1440

agtagaaaat gccagggctt gatggaagag ctgtgtagcc ctttctatgc caaagccagg   1500

aaatttgggg ggcaggagga ggttctcaga atccagtctg tatctttgct gtatgccaaa   1560

ctgaaaccac tgggaataat ttatgaaaca taaaaatctt ctgtacttca ctccaaggta   1620

catttgctta ctgacagcat ttttgttaaa actgttattc ttga                    1664


<210>  6304
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  6304

Met Met Tyr Ile Trp Asn Gly Tyr Ala Val Ile Gly Lys Gln Pro Lys 
1               5                   10                  15      


Leu Thr Asp Gly Ile Leu Glu Ile Ile Thr Lys Ala Glu Glu Met Leu 
            20                  25                  30          


Glu Lys Gly Pro Glu Asn Glu Tyr Ser Val Asp Asp Glu Cys Leu Val 
        35                  40                  45              


Lys Leu Leu Lys Gly Leu Cys Leu Lys Tyr Leu Gly Arg Val Gln Glu 
    50                  55                  60                  


Ala Glu Glu Asn Phe Arg Ser Ile Ser Ala Asn Glu Lys Lys Ile Lys 
65                  70                  75                  80  


Tyr Asp His Tyr Leu Ile Pro Asn Ala Leu Leu Glu Leu Ala Leu Leu 
                85                  90                  95      


Leu Met Glu Gln Asp Arg Asn Glu Glu Ala Ile Lys Leu Leu Glu Ser 
            100                 105                 110         


Ala Lys Gln Asn Tyr Lys Asn Tyr Ser Met Glu Ser Arg Thr His Phe 
        115                 120                 125             


Arg Ile Gln Ala Ala Thr Leu Gln Ala Lys Ser Ser Leu Glu Asn Ser 
    130                 135                 140                 


Ser Arg Ser Met Val Ser Ser Val Ser Leu 
145                 150                 


<210>  6305
<211>  1781
<212>  DNA
<213>  Homosapiens

<400>  6305
acatggcagg ccgttagggc agagggagct gggcagggca cagcagggca ggagtgtgtt     60

tgatgtgtcc tgggaaccgc cctgaggccg tcgtgtggct ggagtgctgc aggtgtcaag    120

gaaattgtag gagatgtctc ctgagtgtga tggaatataa ccagatttcc agaaggaact    180

gacatgatct gacttaaaaa ggccacctac atttacatga aggccgccta cctcagcatg    240

tttgggaagg aggaccacaa gccgttcggg gacgacgaag tggaattatt tcgagctgtg    300

ccaggcctga agctcaagat tgctgggaaa tctctaccca cagagaagtt tgccatccgg    360

aagtcccggc gctacttctc ctccaaccct atctcgctgc cagtgcctgc tctggaaatg    420

atgtacatct ggaacggcta cgccgtgatt gggaagcagc cgaaactcac ggatgggata    480

cttgagatta tcactaaggc tgaagagatg ctggagaaag gcccagagaa cgagtactca    540

gtggatgacg agtgcttggt gaaattgttg aaaggcctgt gtctgaaata cctgggccgt    600

gtccaggagg ccgaggagaa ttttaggagc atctctgcca atgaaaagaa gattaaatat    660

gaccactact tgatcccaaa cgccctgctg gagctggccc tgctgcttat ggagcaagac    720

agaaacgaag aggccatcaa acttttggaa tctgccaagc aaaactacaa gaattactcc    780

atggagtcaa ggacacactt tcgaatccag gcagccacac tccaagccaa gtcttcccta    840

gagaacagca gcagatccat ggtctcatca gtgtccttgt agctttgtgc agcagttccg    900

ggctggaaga cagagacagc tggacagagc tcctgaaaac atttcaaaat accccctccc    960

cctgccctgc cctgcctttg gggtccaccg gcactccagt tggatggcac aacatagtgt   1020

atccgtgcag aagccgagct ggcattttca ccagtgtagc caagggcctt tgccaagggc   1080

agagcaggtg gagccctctg cctgccctat cacacatacg ggtacttgct tttcactgtg   1140

atgtttaaga gaatgtatga acagtttaca ttttccttag aaatacattg atgggatcac   1200

agttggcttt aaaaaccaac aacaatcaac cacctgtaag tctttgtctt cacctattat   1260

catctggagg taaatctctt tatatgatga tgccaaaggg caaattgctt ttcaaattca   1320

gcaagttctc agcttgtgtg acggaaggtc cttcagagga cctgaggaat gcctgggaga   1380

ggctaagcct caggcttcaa tgcttctggg gttgggcatg aggatgtaca cagacaccca   1440

ctaccttact actcacactt catttcactc cttttgtaaa tttccaattt aaaaatcaag   1500

cacgtctttt tagtgagata aaatctgagc tcttctgtag aaaaatcaat ctctaccagt   1560

agaaaatgcc agggcttgat ggaagagctg tgtagccctt tctatgccaa agccaggaaa   1620

tttggggggc aggaggaggt tctcagaatc cagtctgtat ctttgctgta tgccaaactg   1680

aaaccactgg gaataattta tgaaacataa aaatcttctg tacttcactc caaggtacat   1740

ttgcttactg acagcatttt tgttaaaact gttattcttg a                       1781


<210>  6306
<211>  221
<212>  PRT
<213>  Homosapiens

<400>  6306

Met Lys Ala Ala Tyr Leu Ser Met Phe Gly Lys Glu Asp His Lys Pro 
1               5                   10                  15      


Phe Gly Asp Asp Glu Val Glu Leu Phe Arg Ala Val Pro Gly Leu Lys 
            20                  25                  30          


Leu Lys Ile Ala Gly Lys Ser Leu Pro Thr Glu Lys Phe Ala Ile Arg 
        35                  40                  45              


Lys Ser Arg Arg Tyr Phe Ser Ser Asn Pro Ile Ser Leu Pro Val Pro 
    50                  55                  60                  


Ala Leu Glu Met Met Tyr Ile Trp Asn Gly Tyr Ala Val Ile Gly Lys 
65                  70                  75                  80  


Gln Pro Lys Leu Thr Asp Gly Ile Leu Glu Ile Ile Thr Lys Ala Glu 
                85                  90                  95      


Glu Met Leu Glu Lys Gly Pro Glu Asn Glu Tyr Ser Val Asp Asp Glu 
            100                 105                 110         


Cys Leu Val Lys Leu Leu Lys Gly Leu Cys Leu Lys Tyr Leu Gly Arg 
        115                 120                 125             


Val Gln Glu Ala Glu Glu Asn Phe Arg Ser Ile Ser Ala Asn Glu Lys 
    130                 135                 140                 


Lys Ile Lys Tyr Asp His Tyr Leu Ile Pro Asn Ala Leu Leu Glu Leu 
145                 150                 155                 160 


Ala Leu Leu Leu Met Glu Gln Asp Arg Asn Glu Glu Ala Ile Lys Leu 
                165                 170                 175     


Leu Glu Ser Ala Lys Gln Asn Tyr Lys Asn Tyr Ser Met Glu Ser Arg 
            180                 185                 190         


Thr His Phe Arg Ile Gln Ala Ala Thr Leu Gln Ala Lys Ser Ser Leu 
        195                 200                 205             


Glu Asn Ser Ser Arg Ser Met Val Ser Ser Val Ser Leu 
    210                 215                 220     


<210>  6307
<211>  2819
<212>  DNA
<213>  Homosapiens

<400>  6307
cttggagaag gaggagggaa aaaggggctg tgggatttag tggctgggct gcaccccctg     60

ggggggcagc agagcccaat gggccagaag ggccacaaag actcccttta cccttgtgga    120

gggactcctg agagcagcct ccatgaggcc ctggaccagt gcatgaccgc cctggacctc    180

ttcctcacca accagttctc agaagcactc agctacctca agcccagaac caaggaaagc    240

atgtaccact cactgacata tgccaccatc ctggagatgc aggccatgat gacctttgac    300

cctcaggaca tcctgcttgc cggcaacatg atgaaggagg cacagatgct gtgtcagagg    360

caccggagga agtcttctgt aacagattcc ttcagcagcc tggtgaaccg ccccacgctg    420

ggccaattca ctgaagagga aatccacgct gaggtctgct atgcagagtg cctgctgcag    480

cgagcagccc tgaccttcct gcagggttcc tcacacggag gggcagtcag gcccagagcc    540

ttgcatgatc cctctcacgc ctgcagctgc ccacctgggc caggccgtca gcatcttttc    600

ctcctgcagg acgagaacat ggtgagcttc atcaaaggcg gcatcaaagt tcgaaacagc    660

taccagacct acaaggagct ggacagcctt gttcagtcct cacaatactg caagggtgag    720

aaccacccgc actttgaagg aggagtgaag cttggtgtag gggccttcaa cctgacactg    780

tccatgcttc ctactaggat cctgaggctg ttggagtttg tggggttttc aggaaacaag    840

gactatgggc tgctgcagct ggaggaggga gcgtcagggc acagcttccg ctctgtgctc    900

tgtgtcatgc tcctgctgtg ctaccacacc ttcctcacct tcgtgctcgg tactgggaac    960

gtcaacatcg aggaggccga gaagctcttg aagccctacc tgaaccggta ccctaagggt   1020

gccatcttcc tgttctttgc agggaggatt gaagtcatta aaggcaacat tgatgcagcc   1080

atccggcgtt tcgaggagtg ctgtgaggcc cagcagcact ggaagcagtt ccaccacatg   1140

tgctactggg agctgatgtg gtgcttcacc tacaagggcc agtggaagat gtcctacttc   1200

tacgccgacc tgctcagcaa ggagaactgc tggtccaagg ccacctacat ttacatgaag   1260

gccgcctacc tcagcatgtt tgggaaggag gaccacaagc cgttcgggga cgacgaagtg   1320

gaattatttc gagctgtgcc aggcctgaag ctcaagattg ctgggaaatc tctacccaca   1380

gagaagtttg ccatccggaa gtcccggcgc tacttctcct ccaaccctat ctcgctgcca   1440

gtgcctgctc tggaaatgat gtacatctgg aacggctacg ccgtgattgg gaagcagccg   1500

aaactcacgg atgggatact tgagattatc actaaggctg aagagatgct ggagaaaggc   1560

ccagagaacg agtactcagt ggatgacgag tgcttggtga aattgttgaa aggcctgtgt   1620

ctgaaatacc tgggccgtgt ccaggaggcc gaggagaatt ttaggagcat ctctgccaat   1680

gaaaagaaga ttaaatatga ccactacttg atcccaaacg ccctgctgga gctggccctg   1740

ctgcttatgg agcaagacag aaacgaagag gccatcaaac ttttggaatc tgccaagcaa   1800

aactacaaga attactccat ggagtcaagg acacactttc gaatccaggc agccacactc   1860

caagccaagt cttccctaga gaacagcagc agatccatgg tctcatcagt gtccttgtag   1920

ctttgtgcag cagttccggg ctggaagaca gagacagctg gacagagctc ctgaaaacat   1980

ttcaaaatac cccctccccc tgccctgccc tgcctttggg gtccaccggc actccagttg   2040

gatggcacaa catagtgtat ccgtgcagaa gccgagctgg cattttcacc agtgtagcca   2100

agggcctttg ccaagggcag agcaggtgga gccctctgcc tgccctatca cacatacggg   2160

tacttgcttt tcactgtgat gtttaagaga atgtatgaac agtttacatt ttccttagaa   2220

atacattgat gggatcacag ttggctttaa aaaccaacaa caatcaacca cctgtaagtc   2280

tttgtcttca cctattatca tctggaggta aatctcttta tatgatgatg ccaaagggca   2340

aattgctttt caaattcagc aagttctcag cttgtgtgac ggaaggtcct tcagaggacc   2400

tgaggaatgc ctgggagagg ctaagcctca ggcttcaatg cttctggggt tgggcatgag   2460

gatgtacaca gacacccact accttactac tcacacttca tttcactcct tttgtaaatt   2520

tccaatttaa aaatcaagca cgtcttttta gtgagataaa atctgagctc ttctgtagaa   2580

aaatcaatct ctaccagtag aaaatgccag ggcttgatgg aagagctgtg tagccctttc   2640

tatgccaaag ccaggaaatt tggggggcag gaggaggttc tcagaatcca gtctgtatct   2700

ttgctgtatg ccaaactgaa accactggga ataatttatg aaacataaaa atcttctgta   2760

cttcactcca aggtacattt gcttactgac agcatttttg ttaaaactgt tattcttga    2819


<210>  6308
<211>  613
<212>  PRT
<213>  Homosapiens

<400>  6308

Met Gly Gln Lys Gly His Lys Asp Ser Leu Tyr Pro Cys Gly Gly Thr 
1               5                   10                  15      


Pro Glu Ser Ser Leu His Glu Ala Leu Asp Gln Cys Met Thr Ala Leu 
            20                  25                  30          


Asp Leu Phe Leu Thr Asn Gln Phe Ser Glu Ala Leu Ser Tyr Leu Lys 
        35                  40                  45              


Pro Arg Thr Lys Glu Ser Met Tyr His Ser Leu Thr Tyr Ala Thr Ile 
    50                  55                  60                  


Leu Glu Met Gln Ala Met Met Thr Phe Asp Pro Gln Asp Ile Leu Leu 
65                  70                  75                  80  


Ala Gly Asn Met Met Lys Glu Ala Gln Met Leu Cys Gln Arg His Arg 
                85                  90                  95      


Arg Lys Ser Ser Val Thr Asp Ser Phe Ser Ser Leu Val Asn Arg Pro 
            100                 105                 110         


Thr Leu Gly Gln Phe Thr Glu Glu Glu Ile His Ala Glu Val Cys Tyr 
        115                 120                 125             


Ala Glu Cys Leu Leu Gln Arg Ala Ala Leu Thr Phe Leu Gln Gly Ser 
    130                 135                 140                 


Ser His Gly Gly Ala Val Arg Pro Arg Ala Leu His Asp Pro Ser His 
145                 150                 155                 160 


Ala Cys Ser Cys Pro Pro Gly Pro Gly Arg Gln His Leu Phe Leu Leu 
                165                 170                 175     


Gln Asp Glu Asn Met Val Ser Phe Ile Lys Gly Gly Ile Lys Val Arg 
            180                 185                 190         


Asn Ser Tyr Gln Thr Tyr Lys Glu Leu Asp Ser Leu Val Gln Ser Ser 
        195                 200                 205             


Gln Tyr Cys Lys Gly Glu Asn His Pro His Phe Glu Gly Gly Val Lys 
    210                 215                 220                 


Leu Gly Val Gly Ala Phe Asn Leu Thr Leu Ser Met Leu Pro Thr Arg 
225                 230                 235                 240 


Ile Leu Arg Leu Leu Glu Phe Val Gly Phe Ser Gly Asn Lys Asp Tyr 
                245                 250                 255     


Gly Leu Leu Gln Leu Glu Glu Gly Ala Ser Gly His Ser Phe Arg Ser 
            260                 265                 270         


Val Leu Cys Val Met Leu Leu Leu Cys Tyr His Thr Phe Leu Thr Phe 
        275                 280                 285             


Val Leu Gly Thr Gly Asn Val Asn Ile Glu Glu Ala Glu Lys Leu Leu 
    290                 295                 300                 


Lys Pro Tyr Leu Asn Arg Tyr Pro Lys Gly Ala Ile Phe Leu Phe Phe 
305                 310                 315                 320 


Ala Gly Arg Ile Glu Val Ile Lys Gly Asn Ile Asp Ala Ala Ile Arg 
                325                 330                 335     


Arg Phe Glu Glu Cys Cys Glu Ala Gln Gln His Trp Lys Gln Phe His 
            340                 345                 350         


His Met Cys Tyr Trp Glu Leu Met Trp Cys Phe Thr Tyr Lys Gly Gln 
        355                 360                 365             


Trp Lys Met Ser Tyr Phe Tyr Ala Asp Leu Leu Ser Lys Glu Asn Cys 
    370                 375                 380                 


Trp Ser Lys Ala Thr Tyr Ile Tyr Met Lys Ala Ala Tyr Leu Ser Met 
385                 390                 395                 400 


Phe Gly Lys Glu Asp His Lys Pro Phe Gly Asp Asp Glu Val Glu Leu 
                405                 410                 415     


Phe Arg Ala Val Pro Gly Leu Lys Leu Lys Ile Ala Gly Lys Ser Leu 
            420                 425                 430         


Pro Thr Glu Lys Phe Ala Ile Arg Lys Ser Arg Arg Tyr Phe Ser Ser 
        435                 440                 445             


Asn Pro Ile Ser Leu Pro Val Pro Ala Leu Glu Met Met Tyr Ile Trp 
    450                 455                 460                 


Asn Gly Tyr Ala Val Ile Gly Lys Gln Pro Lys Leu Thr Asp Gly Ile 
465                 470                 475                 480 


Leu Glu Ile Ile Thr Lys Ala Glu Glu Met Leu Glu Lys Gly Pro Glu 
                485                 490                 495     


Asn Glu Tyr Ser Val Asp Asp Glu Cys Leu Val Lys Leu Leu Lys Gly 
            500                 505                 510         


Leu Cys Leu Lys Tyr Leu Gly Arg Val Gln Glu Ala Glu Glu Asn Phe 
        515                 520                 525             


Arg Ser Ile Ser Ala Asn Glu Lys Lys Ile Lys Tyr Asp His Tyr Leu 
    530                 535                 540                 


Ile Pro Asn Ala Leu Leu Glu Leu Ala Leu Leu Leu Met Glu Gln Asp 
545                 550                 555                 560 


Arg Asn Glu Glu Ala Ile Lys Leu Leu Glu Ser Ala Lys Gln Asn Tyr 
                565                 570                 575     


Lys Asn Tyr Ser Met Glu Ser Arg Thr His Phe Arg Ile Gln Ala Ala 
            580                 585                 590         


Thr Leu Gln Ala Lys Ser Ser Leu Glu Asn Ser Ser Arg Ser Met Val 
        595                 600                 605             


Ser Ser Val Ser Leu 
    610             


<210>  6309
<211>  2645
<212>  DNA
<213>  Homosapiens

<400>  6309
atggcctttc tgaccacctg gaaggaggcg gcctccggga aaagcgaccg caggactcct     60

gagagcagcc tccatgaggc cctggaccag tgcatgaccg ccctggacct cttcctcacc    120

aaccagttct cagaagcact cagctacctc aagcccagaa ccaaggaaag catgtaccac    180

tcactgacat atgccaccat cctggagatg caggccatga tgacctttga ccctcaggac    240

atcctgcttg ccggcaacat gatgaaggag gcacagatgc tgtgtcagag gcaccggagg    300

aagtcttctg taacagattc cttcagcagc ctggtgaacc gccccacgct gggccaattc    360

actgaagagg aaatccacgc tgaggtctgc tatgcagagt gcctgctgca gcgagcagcc    420

ctgaccttcc tgcaggacga gaacatggtg agcttcatca aaggcggcat caaagttcga    480

aacagctacc agacctacaa ggagctggac agccttgttc agtcctcaca atactgcaag    540

ggtgagaacc acccgcactt tgaaggagga gtgaagcttg gtgtaggggc cttcaacctg    600

acactgtcca tgcttcctac taggatcctg aggctgttgg agtttgtggg gttttcagga    660

aacaaggact atgggctgct gcagctggag gagggagcgt cagggcacag cttccgctct    720

gtgctctgtg tcatgctcct gctgtgctac cacaccttcc tcaccttcgt gctcggtact    780

gggaacgtca acatcgagga ggccgagaag ctcttgaagc cctacctgaa ccggtaccct    840

aagggtgcca tcttcctgtt ctttgcaggg aggattgaag tcattaaagg caacattgat    900

gcagccatcc ggcgtttcga ggagtgctgt gaggcccagc agcactggaa gcagttccac    960

cacatgtgct actgggagct gatgtggtgc ttcacctaca agggccagtg gaagatgtcc   1020

tacttctacg ccgacctgct cagcaaggag aactgctggt ccaaggccac ctacatttac   1080

atgaaggccg cctacctcag catgtttggg aaggaggacc acaagccgtt cggggacgac   1140

gaagtggaat tatttcgagc tgtgccaggc ctgaagctca agattgctgg gaaatctcta   1200

cccacagaga agtttgccat ccggaagtcc cggcgctact tctcctccaa ccctatctcg   1260

ctgccagtgc ctgctctgga aatgatgtac atctggaacg gctacgccgt gattgggaag   1320

cagccgaaac tcacggatgg gatacttgag attatcacta aggctgaaga gatgctggag   1380

aaaggcccag agaacgagta ctcagtggat gacgagtgct tggtgaaatt gttgaaaggc   1440

ctgtgtctga aatacctggg ccgtgtccag gaggccgagg agaattttag gagcatctct   1500

gccaatgaaa agaagattaa atatgaccac tacttgatcc caaacgccct gctggagctg   1560

gccctgctgc ttatggagca agacagaaac gaagaggcca tcaaactttt ggaatctgcc   1620

aagcaaaact acaagaatta ctccatggag tcaaggacac actttcgaat ccaggcagcc   1680

acactccaag ccaagtcttc cctagagaac agcagcagat ccatggtctc atcagtgtcc   1740

ttgtagcttt gtgcagcagt tccgggctgg aagacagaga cagctggaca gagctcctga   1800

aaacatttca aaataccccc tccccctgcc ctgccctgcc tttggggtcc accggcactc   1860

cagttggatg gcacaacata gtgtatccgt gcagaagccg agctggcatt ttcaccagtg   1920

tagccaaggg cctttgccaa gggcagagca ggtggagccc tctgcctgcc ctatcacaca   1980

tacgggtact tgcttttcac tgtgatgttt aagagaatgt atgaacagtt tacattttcc   2040

ttagaaatac attgatggga tcacagttgg ctttaaaaac caacaacaat caaccacctg   2100

taagtctttg tcttcaccta ttatcatctg gaggtaaatc tctttatatg atgatgccaa   2160

agggcaaatt gcttttcaaa ttcagcaagt tctcagcttg tgtgacggaa ggtccttcag   2220

aggacctgag gaatgcctgg gagaggctaa gcctcaggct tcaatgcttc tggggttggg   2280

catgaggatg tacacagaca cccactacct tactactcac acttcatttc actccttttg   2340

taaatttcca atttaaaaat caagcacgtc tttttagtga gataaaatct gagctcttct   2400

gtagaaaaat caatctctac cagtagaaaa tgccagggct tgatggaaga gctgtgtagc   2460

cctttctatg ccaaagccag gaaatttggg gggcaggagg aggttctcag aatccagtct   2520

gtatctttgc tgtatgccaa actgaaacca ctgggaataa tttatgaaac ataaaaatct   2580

tctgtacttc actccaaggt acatttgctt actgacagca tttttgttaa aactgttatt   2640

cttga                                                               2645


<210>  6310
<211>  581
<212>  PRT
<213>  Homosapiens

<400>  6310

Met Ala Phe Leu Thr Thr Trp Lys Glu Ala Ala Ser Gly Lys Ser Asp 
1               5                   10                  15      


Arg Arg Thr Pro Glu Ser Ser Leu His Glu Ala Leu Asp Gln Cys Met 
            20                  25                  30          


Thr Ala Leu Asp Leu Phe Leu Thr Asn Gln Phe Ser Glu Ala Leu Ser 
        35                  40                  45              


Tyr Leu Lys Pro Arg Thr Lys Glu Ser Met Tyr His Ser Leu Thr Tyr 
    50                  55                  60                  


Ala Thr Ile Leu Glu Met Gln Ala Met Met Thr Phe Asp Pro Gln Asp 
65                  70                  75                  80  


Ile Leu Leu Ala Gly Asn Met Met Lys Glu Ala Gln Met Leu Cys Gln 
                85                  90                  95      


Arg His Arg Arg Lys Ser Ser Val Thr Asp Ser Phe Ser Ser Leu Val 
            100                 105                 110         


Asn Arg Pro Thr Leu Gly Gln Phe Thr Glu Glu Glu Ile His Ala Glu 
        115                 120                 125             


Val Cys Tyr Ala Glu Cys Leu Leu Gln Arg Ala Ala Leu Thr Phe Leu 
    130                 135                 140                 


Gln Asp Glu Asn Met Val Ser Phe Ile Lys Gly Gly Ile Lys Val Arg 
145                 150                 155                 160 


Asn Ser Tyr Gln Thr Tyr Lys Glu Leu Asp Ser Leu Val Gln Ser Ser 
                165                 170                 175     


Gln Tyr Cys Lys Gly Glu Asn His Pro His Phe Glu Gly Gly Val Lys 
            180                 185                 190         


Leu Gly Val Gly Ala Phe Asn Leu Thr Leu Ser Met Leu Pro Thr Arg 
        195                 200                 205             


Ile Leu Arg Leu Leu Glu Phe Val Gly Phe Ser Gly Asn Lys Asp Tyr 
    210                 215                 220                 


Gly Leu Leu Gln Leu Glu Glu Gly Ala Ser Gly His Ser Phe Arg Ser 
225                 230                 235                 240 


Val Leu Cys Val Met Leu Leu Leu Cys Tyr His Thr Phe Leu Thr Phe 
                245                 250                 255     


Val Leu Gly Thr Gly Asn Val Asn Ile Glu Glu Ala Glu Lys Leu Leu 
            260                 265                 270         


Lys Pro Tyr Leu Asn Arg Tyr Pro Lys Gly Ala Ile Phe Leu Phe Phe 
        275                 280                 285             


Ala Gly Arg Ile Glu Val Ile Lys Gly Asn Ile Asp Ala Ala Ile Arg 
    290                 295                 300                 


Arg Phe Glu Glu Cys Cys Glu Ala Gln Gln His Trp Lys Gln Phe His 
305                 310                 315                 320 


His Met Cys Tyr Trp Glu Leu Met Trp Cys Phe Thr Tyr Lys Gly Gln 
                325                 330                 335     


Trp Lys Met Ser Tyr Phe Tyr Ala Asp Leu Leu Ser Lys Glu Asn Cys 
            340                 345                 350         


Trp Ser Lys Ala Thr Tyr Ile Tyr Met Lys Ala Ala Tyr Leu Ser Met 
        355                 360                 365             


Phe Gly Lys Glu Asp His Lys Pro Phe Gly Asp Asp Glu Val Glu Leu 
    370                 375                 380                 


Phe Arg Ala Val Pro Gly Leu Lys Leu Lys Ile Ala Gly Lys Ser Leu 
385                 390                 395                 400 


Pro Thr Glu Lys Phe Ala Ile Arg Lys Ser Arg Arg Tyr Phe Ser Ser 
                405                 410                 415     


Asn Pro Ile Ser Leu Pro Val Pro Ala Leu Glu Met Met Tyr Ile Trp 
            420                 425                 430         


Asn Gly Tyr Ala Val Ile Gly Lys Gln Pro Lys Leu Thr Asp Gly Ile 
        435                 440                 445             


Leu Glu Ile Ile Thr Lys Ala Glu Glu Met Leu Glu Lys Gly Pro Glu 
    450                 455                 460                 


Asn Glu Tyr Ser Val Asp Asp Glu Cys Leu Val Lys Leu Leu Lys Gly 
465                 470                 475                 480 


Leu Cys Leu Lys Tyr Leu Gly Arg Val Gln Glu Ala Glu Glu Asn Phe 
                485                 490                 495     


Arg Ser Ile Ser Ala Asn Glu Lys Lys Ile Lys Tyr Asp His Tyr Leu 
            500                 505                 510         


Ile Pro Asn Ala Leu Leu Glu Leu Ala Leu Leu Leu Met Glu Gln Asp 
        515                 520                 525             


Arg Asn Glu Glu Ala Ile Lys Leu Leu Glu Ser Ala Lys Gln Asn Tyr 
    530                 535                 540                 


Lys Asn Tyr Ser Met Glu Ser Arg Thr His Phe Arg Ile Gln Ala Ala 
545                 550                 555                 560 


Thr Leu Gln Ala Lys Ser Ser Leu Glu Asn Ser Ser Arg Ser Met Val 
                565                 570                 575     


Ser Ser Val Ser Leu 
            580     


<210>  6311
<211>  1874
<212>  DNA
<213>  Homosapiens

<400>  6311
acagcgcccg gctcggggtt gcggcggcag cacctgggcc gcgattggcg tccggctggg     60

gcagcgccgc ccgcgcccct cggcgatgac ctcggctggc ggcgccccag gagccctgcc    120

cgcggggact cctgagagca gcctccatga ggccctggac cagtgcatga ccgccctgga    180

cctcttcctc accaaccagt tctcagaagc actcagctac ctcaagccca gaaccaagga    240

aagcatgtac cactcactga catatgccac catcctggag atgcaggcca tgatgacctt    300

tgaccctcag gacatcctgc ttgccggcaa catgatgaag gaggcacaga tgctgtgtca    360

gaggcaccgg aggaagtctt ctgtaacaga ttccttcagc agcctggtga accgccccac    420

gctgggccaa ttcactgaag aggaaatcca cgctgaggtc tgctatgcag agtgcctgct    480

gcagcgagca gccctgacct tcctgcaggg ttcctcacac ggaggggcag tcaggcccag    540

agccttgcat gatccctctc acgcctgcag ctgcccacct gggccaggcc gtcagcatct    600

tttcctcctg caggacgaga acatggtgag cttcatcaaa ggcggcatca aagttcgaaa    660

cagctaccag acctacaagg agctggacag ccttgttcag tcctcacaat actgcaaggg    720

tgagaaccac ccgcactttg aaggaggagt gaagcttggt gtaggggcct tcaacctgac    780

actgtccatg cttcctacta ggatcctgag gctgttggag tttgtggggt tttcaggaaa    840

caaggactat gggctgctgc agctggagga gggagcgtca gggcacagct tccgctctgt    900

gctctgtgtc atgctcctgc tgtgctacca caccttcctc accttcgtgc tcggtactgg    960

gaacgtcaac atcgaggagg ccgagaagct cttgaagccc tacctgaacc ggtaccctaa   1020

gggtgccatc ttcctgttct ttgcagggag gattgaagtc attaaaggca acattgatgc   1080

agccatccgg cgtttcgagg agtgctgtga ggcccagcag cactggaagc agttccacca   1140

catgtgctac tgggagctga tgtggtgctt cacctacaag ggccagtgga agatgtccta   1200

cttctacgcc gacctgctca gcaaggagaa ctgctggtcc aaggccacct acatttacat   1260

gaaggccgcc tacctcagca tgtttgggaa ggaggaccac aagccgttcg gggacgacga   1320

agtggaatta tttcggtggg tcccacatcg tgctcccact gtgtaggcca ctcccaccgt   1380

gtaggccgct atggacagac cagccaggcc accctgagct gtgggcactg gggagggagg   1440

agtagggtgg ctccctgccc ccacccgcgg actgcccccc ctgcgtgtcc tcccctccca   1500

tcaccacccc atgctgctgc tgctggtggt tggagccctt tgactttctt cagaggcttt   1560

ctttcacaga aatggttttg ctaatatcgt cttcctccga gtctctttca tgtggacagt   1620

aggacagatg tggctccaag gtccagggag ggaaggtctt tcactctgct gagttaacct   1680

gagacactca gagaagcaca gtagagagct gacagtcgga atcgaacaaa caagagtaaa   1740

cccagcctct gcttgttctt agctgtgtca ccttggacaa cttcagcatc tgtaaaatgg   1800

gaacaacaac ctccacctcg cagcactgtt ttgcaaatca actagataat aaatgttaag   1860

agcctggcgc atag                                                     1874


<210>  6312
<211>  426
<212>  PRT
<213>  Homosapiens

<400>  6312

Met Thr Ser Ala Gly Gly Ala Pro Gly Ala Leu Pro Ala Gly Thr Pro 
1               5                   10                  15      


Glu Ser Ser Leu His Glu Ala Leu Asp Gln Cys Met Thr Ala Leu Asp 
            20                  25                  30          


Leu Phe Leu Thr Asn Gln Phe Ser Glu Ala Leu Ser Tyr Leu Lys Pro 
        35                  40                  45              


Arg Thr Lys Glu Ser Met Tyr His Ser Leu Thr Tyr Ala Thr Ile Leu 
    50                  55                  60                  


Glu Met Gln Ala Met Met Thr Phe Asp Pro Gln Asp Ile Leu Leu Ala 
65                  70                  75                  80  


Gly Asn Met Met Lys Glu Ala Gln Met Leu Cys Gln Arg His Arg Arg 
                85                  90                  95      


Lys Ser Ser Val Thr Asp Ser Phe Ser Ser Leu Val Asn Arg Pro Thr 
            100                 105                 110         


Leu Gly Gln Phe Thr Glu Glu Glu Ile His Ala Glu Val Cys Tyr Ala 
        115                 120                 125             


Glu Cys Leu Leu Gln Arg Ala Ala Leu Thr Phe Leu Gln Gly Ser Ser 
    130                 135                 140                 


His Gly Gly Ala Val Arg Pro Arg Ala Leu His Asp Pro Ser His Ala 
145                 150                 155                 160 


Cys Ser Cys Pro Pro Gly Pro Gly Arg Gln His Leu Phe Leu Leu Gln 
                165                 170                 175     


Asp Glu Asn Met Val Ser Phe Ile Lys Gly Gly Ile Lys Val Arg Asn 
            180                 185                 190         


Ser Tyr Gln Thr Tyr Lys Glu Leu Asp Ser Leu Val Gln Ser Ser Gln 
        195                 200                 205             


Tyr Cys Lys Gly Glu Asn His Pro His Phe Glu Gly Gly Val Lys Leu 
    210                 215                 220                 


Gly Val Gly Ala Phe Asn Leu Thr Leu Ser Met Leu Pro Thr Arg Ile 
225                 230                 235                 240 


Leu Arg Leu Leu Glu Phe Val Gly Phe Ser Gly Asn Lys Asp Tyr Gly 
                245                 250                 255     


Leu Leu Gln Leu Glu Glu Gly Ala Ser Gly His Ser Phe Arg Ser Val 
            260                 265                 270         


Leu Cys Val Met Leu Leu Leu Cys Tyr His Thr Phe Leu Thr Phe Val 
        275                 280                 285             


Leu Gly Thr Gly Asn Val Asn Ile Glu Glu Ala Glu Lys Leu Leu Lys 
    290                 295                 300                 


Pro Tyr Leu Asn Arg Tyr Pro Lys Gly Ala Ile Phe Leu Phe Phe Ala 
305                 310                 315                 320 


Gly Arg Ile Glu Val Ile Lys Gly Asn Ile Asp Ala Ala Ile Arg Arg 
                325                 330                 335     


Phe Glu Glu Cys Cys Glu Ala Gln Gln His Trp Lys Gln Phe His His 
            340                 345                 350         


Met Cys Tyr Trp Glu Leu Met Trp Cys Phe Thr Tyr Lys Gly Gln Trp 
        355                 360                 365             


Lys Met Ser Tyr Phe Tyr Ala Asp Leu Leu Ser Lys Glu Asn Cys Trp 
    370                 375                 380                 


Ser Lys Ala Thr Tyr Ile Tyr Met Lys Ala Ala Tyr Leu Ser Met Phe 
385                 390                 395                 400 


Gly Lys Glu Asp His Lys Pro Phe Gly Asp Asp Glu Val Glu Leu Phe 
                405                 410                 415     


Arg Trp Val Pro His Arg Ala Pro Thr Val 
            420                 425     


<210>  6313
<211>  6255
<212>  DNA
<213>  Homosapiens

<400>  6313
ggtggagaca ccgcctcagg gctcggtgca cagtggacat ttggggagcg ttgtgggtga     60

cccccacaca ggcactggga atgcagggga gagggggcca agggggaaag gggccagagt    120

gttggctttg gattcaggag ggatggattc cagtcctagc ttgccactta ttaggactcc    180

tgagagcagc ctccatgagg ccctggacca gtgcatgacc gccctggacc tcttcctcac    240

caaccagttc tcagaagcac tcagctacct caagcccaga accaaggaaa gcatgtacca    300

ctcactgaca tatgccacca tcctggagat gcaggccatg atgacctttg accctcagga    360

catcctgctt gccggcaaca tgatgaagga ggcacagatg ctgtgtcaga ggcaccggag    420

gaagtcttct gtaacagatt ccttcagcag cctggtgaac cgccccacgc tgggccaatt    480

cactgaagag gaaatccacg ctgaggtctg ctatgcagag tgcctgctgc agcgagcagc    540

cctgaccttc ctgcagggtt cctcacacgg aggggcagtc aggcccagag ccttgcatga    600

tccctctcac gcctgcagct gcccacctgg gccaggccgt cagcatcttt tcctcctgca    660

ggacgagaac atggtgagct tcatcaaagg cggcatcaaa gttcgaaaca gctaccagac    720

ctacaaggag ctggacagcc ttgttcagtc ctcacaatac tgcaagggtg agaaccaccc    780

gcactttgaa ggaggagtga agcttggtgt aggggccttc aacctgacac tgtccatgct    840

tcctactagg atcctgaggc tgttggagtt tgtggggttt tcaggaaaca aggactatgg    900

gctgctgcag ctggaggagg gagcgtcagg gcacagcttc cgctctgtgc tctgtgtcat    960

gctcctgctg tgctaccaca ccttcctcac cttcgtgctc ggtactggga acgtcaacat   1020

cgaggaggcc gagaagctct tgaagcccta cctgaaccgg taccctaagg gtgccatctt   1080

cctgttcttt gcagggagga ttgaagtcat taaaggcaac attgatgcag tgagtgatgg   1140

gggtccgggc cggggctggg gatccctcgg ggtctcccag accagcagga agtcaggcac   1200

atgtgacata ctcagggaca ggatagactg ggggcggggg gggggccaag agagaaccaa   1260

ccagagagca ggggcaggag aggcccttct ggcagagcag cctgggaaga caagggagga   1320

ggaggcattt gtggtgcctg ggattttgac tgggagatat aggactgcag cattgcagtg   1380

gagggaggtg gagggaggtg cttgagggag gcagaggtta ggaaagccca tctgtttagg   1440

gcatgacgat taggctggag tctggtacct cccctccatt atagctctct cctgctcttt   1500

cattttgtta ctaaaaacca gagtcctagg cgggggctgt atttgagccc aacgtcatgt   1560

aagacttagg aggtaaaacc aggactggag gccagatctc ctggctcctg gggccccacc   1620

tgagcctagc acagggctgg accactatgc cctggaggag tcccggtctg ctgtggtgtt   1680

gggaggttcg gaggatgcag aggggttggg gctgggtggg cacccgtcag gctgaccaga   1740

aggtgcctgc aggccatccg gcgtttcgag gagtgctgtg aggcccagca gcactggaag   1800

cagttccacc acatgtgcta ctgggagctg atgtggtgct tcacctacaa gggccagtgg   1860

aagatgtcct acttctacgc cgacctgctc agcaaggaga actgctggtc caaggtgggc   1920

tgatgccacg tgttaggggc attgggtgac cagggctgac tgtgtgcctc cagaccacgg   1980

gccaaatccc taactgaaca cagatgtctc agctggaatc taaacataac cttaaattct   2040

aataggactc aggcttggaa ggaactaaag accacaagag aaacttctga accacaatgt   2100

gtcacaaaga gatttctagt cacaaaggac agaaacatgg ctccctctgt ccagtagaac   2160

tgtttctgtg gtagaaatgt tctacttatg cactgcccaa atatggtagt caccagccac   2220

atgtgcacaa tgagcacatg aaatgtgcct agtgcaactg ggaaactgat tgttttcagt   2280

tttatttaat tttaattaac taaatgttaa atttaaatag ccatgtaggg cttgtggcca   2340

ctatattgga ctatgcaggt ccaaaacaca aaaggctcat ataactgaac attcttggca   2400

catccgactt caggtagggc tggatccagg aattcaaatg atgtcgtctg gcttggtctt   2460

tccatttgtg gctgtgctct ctcctatgac atctttgttt ctgctgcatc tttgcaggaa   2520

ggttctctcc atgtgacagg caaggtggcc acgggctgct tctactcata tcctcccctt   2580

ggtttcaacc agagtcccac agtttgagcc tcactggtct gacttgtcac ctgccaatgc   2640

ctggaacaga ggggtgggaa gattcctcat gggctgagag taggagaggg gtggttccac   2700

agaagaaaat gatgcaccca gaaatagtgg agggattaac aagatgccat acaggcaaaa   2760

caaagccaaa cagatgcccg cctaccaaag atgaaattta tcatggtaag tattgaaata   2820

agtgttagct tgtaccatca tagtaatgat agtgcagaaa ttggaaccaa gagtcttaca   2880

accacctagc tcagcaaacg tctaatctgt tatttgtaaa tacacaggac atgtgtcttc   2940

atggcttcat cccctgccca tagcagacat tgctaatcaa tcctctgcca tgagcctagc   3000

tgtgacctta gataccttcc ctgcaaagct ccaggcagcc gttagaactg acccacattg   3060

gcacctgtta ggagacctgt catctgcatc tggtccctcc ccctcctctg catggaggtc   3120

tcttccgtag ccctgcctgg ggaccaagct gaaggggaat tctctgggtc tggggcaggt   3180

ggggctgggg aagggagcag gcttctactg agctctcaac atgtctggca cctgtcatgt   3240

cctccacacc acacccagtg aggagaagtt attatctcca ttgggcacat gagggccact   3300

gatgctaagc gaggactgtg actttcccac ccacatggct gttggtgaca gacaccggat   3360

ttgaggacag tcctgtgtga ctcagaggcc tctgcttctc tcttgctcct agagtcctcc   3420

tgaggagtcg gggcttgccc tgagcccacc ctgctgttga aggtgcttcc tcaggcccag   3480

ctcccatggc ccccacaccc cctcctcatc acctcctact cccaaaaagg acaaagcctc   3540

agggaacctt ttttcttttt ttagagacag ggtcttgcta tgttggtcag gctagtcttg   3600

aactcctggg cccaagcaat cttcccacct ctgcctccta aagtgctggg attctgggcc   3660

ttagggaacc tttttgaact gaaagtgact ctcgaagcct tcctgtagag tgaggtgggt   3720

ggctggggct aaccatatgg ggaaggagag acctggtggg ggcacacagc tgctatatag   3780

aggaacagaa ggtgggccag gcctcccagc tgtcaggaaa tctggctcag tccccagacc   3840

gctgtgtggc tttggggtgg ccagtccctc tctctctgca acactctcct catgaggact   3900

tctgtgaaaa atgggggttg taaccctctg agttctgggg ccccacccat ttctaatctc   3960

cagaacttgg ccaccacaga ctccaccaac ttctagtcct ggggcctggg cctctggcca   4020

ttgccatagg caccacctgc tctgtgcagg cagcgccccc ctctgccagg atcctccgag   4080

gtcagctgct gggtctgacc cgcagaccct ggctgagcga cggatgaacg gagtatgcag   4140

acacaggctt gcctgtcagc agatggggga cccctgccag agtcagcagc ggcccccata   4200

agcctgccac gcttgcattt atttagtaca gatgtaatga caaaggccta aagcaaactc   4260

catttgtggg taattaacat tgtcgccccc ccagaaagag cagtcctccg catgatgatt   4320

aaaggccagg ttccgaggcc taagtaaacc aacttatcta gatcaattcc cttacttctt   4380

gttatctact ctgagagaat tcagctgcct tcagccaaat cctttcccga agcttttgca   4440

aaacctccga gccttccaag gtttgcttct ttctgtaatt tttctcacca ccctgaccta   4500

tctcctgcag tcagccctgt ggaggccttt gtgtttcccc cagtgctggc agcctagagg   4560

ctgagatggc cagaaacaag gtggtgacag tggcgtgctc agggcttggg aaacccaagg   4620

agctaaaggc atgcccaggc aaccaaagag gacaggaagg cttctgagga gagacctctg   4680

aggtgggtct tggagaggaa ggacttaggg aggcagagtg gaggaagtga gaggacaccc   4740

caagccaaga gggcggcagg accaaaggct cagaagccag ggcgctgcag aggggctgtg   4800

tgccacaggg tgaagagttt gtgtggcaga agggcagggg gcttgcatca ggggtgacag   4860

ctgctctttt gtcccagcat agcccctgta catccctgga gagctggggc gtccacaact   4920

ctaagtcaca gcccccatcc taaccctggt ggtgcagtga gggtgagctg tctgtgggca   4980

ggagggaaga ctcttggaga tgagcctggt gaagggataa tggcatcccg ggccgaggag   5040

cagcacaggc agaggcctgg ggagagttta aggagtgtag gggaggaaat ggcagaagat   5100

gagccagaaa aagaaaggtt agggcaggtc ctggaggaca tgagtggctg tttgggcttt   5160

atccagcagt gggggagcct tggcaggctt gtggcttaga taggtgcttt agaaagccca   5220

ccagcagttg ctgggccacc ccgctggctg ggtcctgttc taaggcagga aatacaagca   5280

tgagcaggaa aagaccccct caaggctcac gtcctagtgg ggagacaaga aacacagatg   5340

ggcaatataa cacgatgtct ggttccagta agtgcagtga agaacaagcg aggctggatg   5400

cagggagtga tgggaggggc tttgtaaggg gaggtcgggg gaagcctgtc tcagaggaca   5460

ccagaatgga gcgcaggagc agcacgtggc agtcacatgg caggccgtta gggcagaggg   5520

agctgggcag ggcacagcag ggcaggagtg tgtttgatgt gtcctgggaa ccgccctgag   5580

gccgtcgtgt ggctggagtg ctgcaggtgt caaggaaatt gtaggagatg tctcctgagt   5640

gtgatggaat ataaccagat ttccagaagg aactgacatg atctgactta aaaaggtcag   5700

tgtgcgaaat ggcttgcagg ggacaggagt gggagcaggg agataggaga caatgtgtac   5760

caggacagca gaaagacatc ccgggtagcc tggaacaggg agacggtgtg gagatggtgg   5820

cagtccgata atgagagccg tagggcaagg ccagcaggat cctagagtga gacgggaggt   5880

aaagtcaccg ggacttggtg tctccacgtc aggggcaggg gaaagggaga ggacaagggt   5940

gacccgggag gttaaagatg ggaccggggc cagacgcagt ggctcatgcc tgtaatccta   6000

gcactttggg aggctgaggc gggcggatag cttgaggtca ggagtttgaa accagcctgg   6060

ccaacatggt gaaaccccgt ctctactaaa atatacaaaa attagcctgg cgtggtggtg   6120

catgcctgca gtcccagcta ttcaggaggc tgaggcaaca agaatcgctt gaacctggga   6180

ggcggaggtt gcagtgagcc gagatcgcgc catagcactc cagccttagc ctgggcgaca   6240

gagcgagacc acatc                                                    6255


<210>  6314
<211>  420
<212>  PRT
<213>  Homosapiens

<400>  6314

Met Asp Ser Ser Pro Ser Leu Pro Leu Ile Arg Thr Pro Glu Ser Ser 
1               5                   10                  15      


Leu His Glu Ala Leu Asp Gln Cys Met Thr Ala Leu Asp Leu Phe Leu 
            20                  25                  30          


Thr Asn Gln Phe Ser Glu Ala Leu Ser Tyr Leu Lys Pro Arg Thr Lys 
        35                  40                  45              


Glu Ser Met Tyr His Ser Leu Thr Tyr Ala Thr Ile Leu Glu Met Gln 
    50                  55                  60                  


Ala Met Met Thr Phe Asp Pro Gln Asp Ile Leu Leu Ala Gly Asn Met 
65                  70                  75                  80  


Met Lys Glu Ala Gln Met Leu Cys Gln Arg His Arg Arg Lys Ser Ser 
                85                  90                  95      


Val Thr Asp Ser Phe Ser Ser Leu Val Asn Arg Pro Thr Leu Gly Gln 
            100                 105                 110         


Phe Thr Glu Glu Glu Ile His Ala Glu Val Cys Tyr Ala Glu Cys Leu 
        115                 120                 125             


Leu Gln Arg Ala Ala Leu Thr Phe Leu Gln Gly Ser Ser His Gly Gly 
    130                 135                 140                 


Ala Val Arg Pro Arg Ala Leu His Asp Pro Ser His Ala Cys Ser Cys 
145                 150                 155                 160 


Pro Pro Gly Pro Gly Arg Gln His Leu Phe Leu Leu Gln Asp Glu Asn 
                165                 170                 175     


Met Val Ser Phe Ile Lys Gly Gly Ile Lys Val Arg Asn Ser Tyr Gln 
            180                 185                 190         


Thr Tyr Lys Glu Leu Asp Ser Leu Val Gln Ser Ser Gln Tyr Cys Lys 
        195                 200                 205             


Gly Glu Asn His Pro His Phe Glu Gly Gly Val Lys Leu Gly Val Gly 
    210                 215                 220                 


Ala Phe Asn Leu Thr Leu Ser Met Leu Pro Thr Arg Ile Leu Arg Leu 
225                 230                 235                 240 


Leu Glu Phe Val Gly Phe Ser Gly Asn Lys Asp Tyr Gly Leu Leu Gln 
                245                 250                 255     


Leu Glu Glu Gly Ala Ser Gly His Ser Phe Arg Ser Val Leu Cys Val 
            260                 265                 270         


Met Leu Leu Leu Cys Tyr His Thr Phe Leu Thr Phe Val Leu Gly Thr 
        275                 280                 285             


Gly Asn Val Asn Ile Glu Glu Ala Glu Lys Leu Leu Lys Pro Tyr Leu 
    290                 295                 300                 


Asn Arg Tyr Pro Lys Gly Ala Ile Phe Leu Phe Phe Ala Gly Arg Ile 
305                 310                 315                 320 


Glu Val Ile Lys Gly Asn Ile Asp Ala Val Ser Asp Gly Gly Pro Gly 
                325                 330                 335     


Arg Gly Trp Gly Ser Leu Gly Val Ser Gln Thr Ser Arg Lys Ser Gly 
            340                 345                 350         


Thr Cys Asp Ile Leu Arg Asp Arg Ile Asp Trp Gly Arg Gly Gly Gly 
        355                 360                 365             


Gln Glu Arg Thr Asn Gln Arg Ala Gly Ala Gly Glu Ala Leu Leu Ala 
    370                 375                 380                 


Glu Gln Pro Gly Lys Thr Arg Glu Glu Glu Ala Phe Val Val Pro Gly 
385                 390                 395                 400 


Ile Leu Thr Gly Arg Tyr Arg Thr Ala Ala Leu Gln Trp Arg Glu Val 
                405                 410                 415     


Glu Gly Gly Ala 
            420 


<210>  6315
<211>  763
<212>  DNA
<213>  Homosapiens

<400>  6315
cagctcacct gggccggctc tctgcccagc aacctcccag cagtcagggc tcctagcagc     60

tgccccctgc cctgcccact ggggcccagg aaaagcagag agttgctgaa ggtctcccgg    120

cagtagcggc tgtcactgct acggggggtg atctaggagt gaacgccacg aggcaggtgg    180

ggaaggctgc tctgaacgtg tctgtgacta cagctccgtg agaaagttgg gacccagaag    240

atgaaaaatg agctcagtaa gggaagcaga agagccgcct ttagagctgg aactctcccc    300

acaccatcac agcgaacagt gatgctagag ccagtcacct ggtgagtcag cgcatcagag    360

tggcccaccc ctcaggaggg ccccacccag gccgttcctg gcccccagga gctctggccc    420

agccccagca caggggagtc tgtgagtcac catcatcatt tctgcctccc caactcaagt    480

gaccttactt ggatcacctg tgtgtcccca ccttgaggtg acagctgggc cctggcgatg    540

ggacagcatc ctgagtcctg gatgccttcc tcctgtcagg agacctgttt cctggtgcgt    600

tacatctggg agatgccagg cctgctttcc tccctcattt cctccccagc gtgcaagaac    660

aaatcaccag tgtcaccaca cctctcaatg gccctgagaa cttcatggac tgctttcacc    720

tgtgccattg tcaacttaag aaggccctta atatggccgg gcg                      763


<210>  6316
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  6316

Met Lys Asn Glu Leu Ser Lys Gly Ser Arg Arg Ala Ala Phe Arg Ala 
1               5                   10                  15      


Gly Thr Leu Pro Thr Pro Ser Gln Arg Thr Val Met Leu Glu Pro Val 
            20                  25                  30          


Thr Trp 
        


<210>  6317
<211>  554
<212>  DNA
<213>  Homosapiens

<400>  6317
agagagttgc tgaaggtctc ccggcagtag cggctgtcac tgctacgggg ggtgatctag     60

gagtgaacgc cacgaggcag gtggggaagg ctgctctgaa cgtgtctgtg actacagctc    120

cgtgagaaag ttgggaccca gaagcttccg ccccgaagcg gcccccacct gagccgtcac    180

catcctcccg cattaatggg ggcattcgtg cagacaaaga cagcccccag agtcaggcct    240

ggattttaat cccaccatct cgcccactga gtgactgcag gagaccagaa ggcggggaaa    300

acacggttta gcactcactg ctagctggca gttcacactg ccttctcaaa tgatccccat    360

aattgctatt ttacagatgg ggaaactgag gcatggggtt catttgattc acgcatggtc    420

actcacctaa taagtggcaa gctaggactg gaatccatcc ctcctgaatc caaagccaac    480

actctggccc ctttccccct tggccccctc tcccctgcat tcccagtgcc tgtgtggggg    540

tcacccacaa cgct                                                      554


<210>  6318
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  6318

Met Val Thr His Leu Ile Ser Gly Lys Leu Gly Leu Glu Ser Ile Pro 
1               5                   10                  15      


Pro Glu Ser Lys Ala Asn Thr Leu Ala Pro Phe Pro Leu Gly Pro Leu 
            20                  25                  30          


Ser Pro Ala Phe Pro Val Pro Val Trp Gly Ser Pro Thr 
        35                  40                  45  


<210>  6319
<211>  5229
<212>  DNA
<213>  Homosapiens

<400>  6319
ggcctcgcct gcggccgctc cctccgcctc ctccccgccc cgagccccag tcagcccgtc     60

ttccttcccc tcccttgcat gatggaaaca ccatggctgc ggcggcccag ctctctctga    120

cacagttatc aagtgggaat cctgtatatg aaaaatacta tagacaggtt gatacaggca    180

atactggaag ggtgttggct tctgatgctg ctgctttcct gaaaaaatca gggcttccag    240

acttgatact tggaaagatt tgggatttag ccgacacaga tggcaaaggt atcctgaaca    300

aacaagaatt ctttgttgct ttgcgtcttg tggcatgtgc ccagaatgga ttggaagttt    360

cactaagtag tttgaacctg gctgttcctc caccaagatt tcatgatacc agtagtcctt    420

tgctaatcag tggaacctct gcagctgagc tcccatgggc tgtaaaacct gaagataagg    480

ccaaatatga tgcaatattt gatagtttaa gcccagtgaa tggatttctg tctggtgata    540

aagtgaaacc agtgttgctc aactctaagt tacctgtgga tatccttgga agagtttggg    600

agttgagtga tattgaccat gatggaatgc ttgacagaga tgagtttgca gttgccatgt    660

ttttggtata ctgtgcactg gagaaagaac ctgtgccaat gtccttgcct ccagccttgg    720

tgccaccatc taagagaaaa acgtgggttg tatcccctgc agaaaaagct aaatatgatg    780

aaatcttcct gaaaactgat aaagatatgg acggatttgt gtctggattg gaggtccgtg    840

aaatattctt gaaaacaggt ttaccttcta ccttactagc ccatatatgg tcattatgcg    900

acacaaagga ctgtgggaag ctttcaaagg atcagtttgc cttggctttt cacttaatca    960

gtcagaagtt aatcaagggc attgatcctc ctcacgttct tactcctgaa atgattccac   1020

catcagacag ggccagttta caaaagaaca tcataggatc aagtcctgtt gcagatttct   1080

ctgctattaa ggaactagat actcttaaca atgaaatagt tgacctacag agggaaaaga   1140

ataatgtgga acaggacctt aaggagaagg aagatactat taaacagagg acaagtgagg   1200

ttcaggatct tcaagatgaa gttcaaaggg agaatactaa tctgcaaaaa ctacaggccc   1260

agaaacagca ggtacaggaa ctccttgatg aactggatga gcagaaagcc cagctggagg   1320

agcaactcaa ggaagtcaga aagaaatgtg ctgaggaggc ccaactgatc tcttctctga   1380

aagctgaatt aactagtcag gaatcgcaga tctccactta cgaagaagaa ttggcaaaag   1440

ctagagaaga gctgagccgt ctacagcaag aaacagcaga attggaggag agtgtagagt   1500

cagggaaggc tcagttggaa cctcttcagc agcacctaca agattcacaa caggaaatta   1560

gttcaatgca aatgaaactg atggaaatga aagatttgga aaatcataat agtcagttaa   1620

attggtgcag tagcccacac agcattcttg taaacggagc tacagattat tgcagcctca   1680

gcaccagcag cagtgaaaca gccaacctta atgaacatgt tgaaggccag agcaacctag   1740

agtctgagcc catacaccag gaatctccag caagaagtag tcctgaacta ctgccttctg   1800

gtgtgactga tgaaaatgag gtgactacag ctgttactga aaaagtttgt tctgaactcg   1860

acaataatag acattcaaaa gaggaagatc catttaatgt agactcaagt tcgctgacag   1920

gtccagttgc agatacaaac ttggattttt tccagtctga tccttttgtt ggcagtgatc   1980

ctttcaagga tgatcctttt ggaaaaatcg atccatttgg tggtgatcct ttcaaaggtt   2040

cagatccatt tgcatcagac tgtttcttca ggcaatctac tgatcctttt gccacttcaa   2100

gcactgaccc tttcagtgca gccaacaata gcagtattac atcggtagaa acgttgaagc   2160

acaatgatcc ttttgctcct ggtggaacag ttgttgcagc aagcgattca gccacagacc   2220

cctttgcttc tgtttttggg aatgaatcat ttggaggtgg atttgctgac ttcagcacat   2280

tgtcaaaggt caacaatgaa gatccttttc gttcagccac atcgagctct gtcagcaacg   2340

tagtgattac aaaaaatgta tttgaggaaa catcggtcaa aagtgaagat gaacccccag   2400

cactgccacc aaagatcgga actccaacaa gaccctgccc tctaccacct gggaaaagat   2460

ccatcaacaa attggattct cctgatccct ttaaactgaa tgatccattt cagcctttcc   2520

caggcaacga tagccccaaa gaaaaagatc ctgaaatatt ttgtgatcca ttcacttctg   2580

ctactaccac taccaataaa gaggctgatc caagcaattt tgccaacttc agtgcttatc   2640

cctctgaaga agatatgatc gaatgggcca agagggaaag tgagagagag gaagagcaga   2700

ggcttgcccg actaaatcag caggaacaag aagacttaga actggctatt gcactcagca   2760

aatctgagat atcagaagca tgaagaattc tcttgttctt tggcaacaat atagtattct   2820

tcttcctgaa tactgaaact atttacaatg tgtatcaaaa ctacctgtga gcatgggaat   2880

acaaaaggtt tgagattcct gtaaatgtga caaaatttta ggattttttt tttttcttca   2940

ttacagattc gtcttttttt ttttttctta taaaagccgt aacccagtca gacaaattca   3000

ccttcactta ggcccctgtt ctggtataca tttactgtga gcttttgcct gcctgtgcta   3060

ttttacttgt aaagctagag cacccaagct tctgccttct ggaatataga gaaatagttt   3120

caccctgcac taccctgttc tgtagttatt ctgatgatag ccagtgaggt tcttaaagtt   3180

tgcagtattc tcccctgatt ggaatggttg agtgagggta agggaaagaa tatcttattt   3240

cttttatgat tggtgcaaat tggctaaagt gcatttttaa atttcctcta cttaatttgt   3300

ttttcagaga taaggaaaaa tattttgcac agatttactc cactatggaa aagggatgct   3360

gtaggttgaa ccattatagc ctcagattcg atcttttcct aactaaaaat attaaagcct   3420

catgtgtgaa ataaattttt aaaaagattt atctggattt agagaatttt agatcaacag   3480

atacctctca gtgtgtttgc taattaataa aaatcagttt cttacaaata aagtttgtaa   3540

gaaaatgttc attttaagtg atagatagtg gagaaaattt atcacctaaa atatacccat   3600

cagtataagg caagcaaaag tcttaacatg gcagccattc tgcctttgcc gtggccctgt   3660

cctgtttagt tcttagtggg ttaatttttg tacttttgca gaagaaactt cagcaagcta   3720

gaactggaag gtactttaat ttttcatata tatttgtttt ttttttttta atgaaggctc   3780

atttacttga aatgtaaaaa ctttcactga atacaaatag aaaaagtgat gtgttttata   3840

tcatattgct ttttgtccat ctttgtggtt tagtttattt actcacttca tgtttttcac   3900

ctataaaatt gtcaagctag caaaaaaact cttgtttttt taattgggag agaagagacc   3960

tgccagatta tcagacctct tcatgttaaa agaccatctc ctgtaaaact gacctagtgg   4020

acaagctgaa tttgaaatag actgtgaagt aagctgtaac ttgtcatttt aattttgttt   4080

aacacggtta ctgacttaga tgatgtatta aataccaaga taaagaaaaa tgcacctaaa   4140

atctaattag aattctctgg gtcaacaagt caaggtggta ttgatctgtg ttaatctgag   4200

taacttattg cctagcctat aaataaattc caaaatatcc aattcatttc ttcttgaaat   4260

ggtgcttgtt ttgttttctt tccattacac aattagactc ctacagttta aaacaaactt   4320

taaaccacta tcttgcactg ctaacttttt tctacctttg taaatagaaa catttctgca   4380

taaaagtcat acatatgaag caagggctga atcataatca caaggcttaa ttttgataaa   4440

cgaatccagt gacctaagga ttttctgcaa aatttgactg ggagttgtga taggtggtat   4500

ttttgtttat tttcttcctc ttactcctta ggataaaggt aagttgactt gaacaacttt   4560

cttttgcact gggaaaataa gcaaatgttt aaatgcttca aaaaaatttt caattaaact   4620

caaatattaa atatctataa cttataaaca ccaactttca atgtaataaa tgtatcctaa   4680

tcttatgtat gtttaactgg attacataga tttttatctt ttgttaaaat gtgtataccc   4740

cgtggaccaa cataatatta aagtatgtat atattatata aatatatatg tatatgtgct   4800

cgcttgtgta ggatgaatgt cttagagtcg tttgtggtat tttatgttgt tgactctggc   4860

tccagggcct gtgcttgaaa aggacagata agtattgccc agagctaagt ggcactactt   4920

acaaagtttt aaatgtcttc tacatactga ttcatgttta tttgagctct ctttatagaa   4980

ttttctctta aagtttcaaa cctctaagtt gtagcctgta attatgagaa cagtaaactt   5040

taagtaataa taaagaatcc catccatata tccaatttgc aattgagttt tgcatggttc   5100

tctgattatg tccatgctgt gtccaaggag gagtaggtac atacaatcag cacagattaa   5160

tatatgtaaa gggtttggga cagcacctgg tatagaataa ataataaatg taaactatta   5220

tttttggtt                                                           5229


<210>  6320
<211>  896
<212>  PRT
<213>  Homosapiens

<400>  6320

Met Ala Ala Ala Ala Gln Leu Ser Leu Thr Gln Leu Ser Ser Gly Asn 
1               5                   10                  15      


Pro Val Tyr Glu Lys Tyr Tyr Arg Gln Val Asp Thr Gly Asn Thr Gly 
            20                  25                  30          


Arg Val Leu Ala Ser Asp Ala Ala Ala Phe Leu Lys Lys Ser Gly Leu 
        35                  40                  45              


Pro Asp Leu Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Thr Asp Gly 
    50                  55                  60                  


Lys Gly Ile Leu Asn Lys Gln Glu Phe Phe Val Ala Leu Arg Leu Val 
65                  70                  75                  80  


Ala Cys Ala Gln Asn Gly Leu Glu Val Ser Leu Ser Ser Leu Asn Leu 
                85                  90                  95      


Ala Val Pro Pro Pro Arg Phe His Asp Thr Ser Ser Pro Leu Leu Ile 
            100                 105                 110         


Ser Gly Thr Ser Ala Ala Glu Leu Pro Trp Ala Val Lys Pro Glu Asp 
        115                 120                 125             


Lys Ala Lys Tyr Asp Ala Ile Phe Asp Ser Leu Ser Pro Val Asn Gly 
    130                 135                 140                 


Phe Leu Ser Gly Asp Lys Val Lys Pro Val Leu Leu Asn Ser Lys Leu 
145                 150                 155                 160 


Pro Val Asp Ile Leu Gly Arg Val Trp Glu Leu Ser Asp Ile Asp His 
                165                 170                 175     


Asp Gly Met Leu Asp Arg Asp Glu Phe Ala Val Ala Met Phe Leu Val 
            180                 185                 190         


Tyr Cys Ala Leu Glu Lys Glu Pro Val Pro Met Ser Leu Pro Pro Ala 
        195                 200                 205             


Leu Val Pro Pro Ser Lys Arg Lys Thr Trp Val Val Ser Pro Ala Glu 
    210                 215                 220                 


Lys Ala Lys Tyr Asp Glu Ile Phe Leu Lys Thr Asp Lys Asp Met Asp 
225                 230                 235                 240 


Gly Phe Val Ser Gly Leu Glu Val Arg Glu Ile Phe Leu Lys Thr Gly 
                245                 250                 255     


Leu Pro Ser Thr Leu Leu Ala His Ile Trp Ser Leu Cys Asp Thr Lys 
            260                 265                 270         


Asp Cys Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala Phe His Leu 
        275                 280                 285             


Ile Ser Gln Lys Leu Ile Lys Gly Ile Asp Pro Pro His Val Leu Thr 
    290                 295                 300                 


Pro Glu Met Ile Pro Pro Ser Asp Arg Ala Ser Leu Gln Lys Asn Ile 
305                 310                 315                 320 


Ile Gly Ser Ser Pro Val Ala Asp Phe Ser Ala Ile Lys Glu Leu Asp 
                325                 330                 335     


Thr Leu Asn Asn Glu Ile Val Asp Leu Gln Arg Glu Lys Asn Asn Val 
            340                 345                 350         


Glu Gln Asp Leu Lys Glu Lys Glu Asp Thr Ile Lys Gln Arg Thr Ser 
        355                 360                 365             


Glu Val Gln Asp Leu Gln Asp Glu Val Gln Arg Glu Asn Thr Asn Leu 
    370                 375                 380                 


Gln Lys Leu Gln Ala Gln Lys Gln Gln Val Gln Glu Leu Leu Asp Glu 
385                 390                 395                 400 


Leu Asp Glu Gln Lys Ala Gln Leu Glu Glu Gln Leu Lys Glu Val Arg 
                405                 410                 415     


Lys Lys Cys Ala Glu Glu Ala Gln Leu Ile Ser Ser Leu Lys Ala Glu 
            420                 425                 430         


Leu Thr Ser Gln Glu Ser Gln Ile Ser Thr Tyr Glu Glu Glu Leu Ala 
        435                 440                 445             


Lys Ala Arg Glu Glu Leu Ser Arg Leu Gln Gln Glu Thr Ala Glu Leu 
    450                 455                 460                 


Glu Glu Ser Val Glu Ser Gly Lys Ala Gln Leu Glu Pro Leu Gln Gln 
465                 470                 475                 480 


His Leu Gln Asp Ser Gln Gln Glu Ile Ser Ser Met Gln Met Lys Leu 
                485                 490                 495     


Met Glu Met Lys Asp Leu Glu Asn His Asn Ser Gln Leu Asn Trp Cys 
            500                 505                 510         


Ser Ser Pro His Ser Ile Leu Val Asn Gly Ala Thr Asp Tyr Cys Ser 
        515                 520                 525             


Leu Ser Thr Ser Ser Ser Glu Thr Ala Asn Leu Asn Glu His Val Glu 
    530                 535                 540                 


Gly Gln Ser Asn Leu Glu Ser Glu Pro Ile His Gln Glu Ser Pro Ala 
545                 550                 555                 560 


Arg Ser Ser Pro Glu Leu Leu Pro Ser Gly Val Thr Asp Glu Asn Glu 
                565                 570                 575     


Val Thr Thr Ala Val Thr Glu Lys Val Cys Ser Glu Leu Asp Asn Asn 
            580                 585                 590         


Arg His Ser Lys Glu Glu Asp Pro Phe Asn Val Asp Ser Ser Ser Leu 
        595                 600                 605             


Thr Gly Pro Val Ala Asp Thr Asn Leu Asp Phe Phe Gln Ser Asp Pro 
    610                 615                 620                 


Phe Val Gly Ser Asp Pro Phe Lys Asp Asp Pro Phe Gly Lys Ile Asp 
625                 630                 635                 640 


Pro Phe Gly Gly Asp Pro Phe Lys Gly Ser Asp Pro Phe Ala Ser Asp 
                645                 650                 655     


Cys Phe Phe Arg Gln Ser Thr Asp Pro Phe Ala Thr Ser Ser Thr Asp 
            660                 665                 670         


Pro Phe Ser Ala Ala Asn Asn Ser Ser Ile Thr Ser Val Glu Thr Leu 
        675                 680                 685             


Lys His Asn Asp Pro Phe Ala Pro Gly Gly Thr Val Val Ala Ala Ser 
    690                 695                 700                 


Asp Ser Ala Thr Asp Pro Phe Ala Ser Val Phe Gly Asn Glu Ser Phe 
705                 710                 715                 720 


Gly Gly Gly Phe Ala Asp Phe Ser Thr Leu Ser Lys Val Asn Asn Glu 
                725                 730                 735     


Asp Pro Phe Arg Ser Ala Thr Ser Ser Ser Val Ser Asn Val Val Ile 
            740                 745                 750         


Thr Lys Asn Val Phe Glu Glu Thr Ser Val Lys Ser Glu Asp Glu Pro 
        755                 760                 765             


Pro Ala Leu Pro Pro Lys Ile Gly Thr Pro Thr Arg Pro Cys Pro Leu 
    770                 775                 780                 


Pro Pro Gly Lys Arg Ser Ile Asn Lys Leu Asp Ser Pro Asp Pro Phe 
785                 790                 795                 800 


Lys Leu Asn Asp Pro Phe Gln Pro Phe Pro Gly Asn Asp Ser Pro Lys 
                805                 810                 815     


Glu Lys Asp Pro Glu Ile Phe Cys Asp Pro Phe Thr Ser Ala Thr Thr 
            820                 825                 830         


Thr Thr Asn Lys Glu Ala Asp Pro Ser Asn Phe Ala Asn Phe Ser Ala 
        835                 840                 845             


Tyr Pro Ser Glu Glu Asp Met Ile Glu Trp Ala Lys Arg Glu Ser Glu 
    850                 855                 860                 


Arg Glu Glu Glu Gln Arg Leu Ala Arg Leu Asn Gln Gln Glu Gln Glu 
865                 870                 875                 880 


Asp Leu Glu Leu Ala Ile Ala Leu Ser Lys Ser Glu Ile Ser Glu Ala 
                885                 890                 895     


<210>  6321
<211>  5079
<212>  DNA
<213>  Homosapiens

<400>  6321
ggcctcgcct gcggccgctc cctccgcctc ctccccgccc cgagccccag tcagcccgtc     60

ttccttcccc tcccttgcat gatggaaaca ccatggctgc ggcggcccag ctctctctga    120

cacagttatc aagtgggaat cctgtatatg aaaaatacta tagacaggtt gatacaggca    180

atactggaag ggtgttggct tctgatgctg ctgctttcct gaaaaaatca gggcttccag    240

acttgatact tggaaagatt tgggatttag ccgacacaga tggcaaaggt atcctgaaca    300

aacaagaatt ctttgttgct ttgcgtcttg tggcatgtgc ccagaatgga ttggaagttt    360

cactaagtag tttgaacctg gctgttcctc caccaagatt tcatgatacc agtagtcctt    420

tgctaatcag tggaacctct gcagctgagc tcccatgggc tgtaaaacct gaagataagg    480

ccaaatatga tgcaatattt gatagtttaa gcccagtgaa tggatttctg tctggtgata    540

aagtgaaacc agtgttgctc aactctaagt tacctgtgga tatccttgga agagtttggg    600

agttgagtga tattgaccat gatggaatgc ttgacagaga tgagtttgca gttgccatgt    660

ttttggtata ctgtgcactg gagaaagaac ctgtgccaat gtccttgcct ccagccttgg    720

tgccaccatc taagagaaaa acgtgggttg tatcccctgc agaaaaagct aaatatgatg    780

aaatcttcct gaaaactgat aaagatatgg acggatttgt gtctggattg gaggtccgtg    840

aaatattctt gaaaacaggt ttaccttcta ccttactagc ccatatatgg tcattatgcg    900

acacaaagga ctgtgggaag ctttcaaagg atcagtttgc cttggctttt cacttaatca    960

gtcagaagtt aatcaagggc attgatcctc ctcacgttct tactcctgaa atgattccac   1020

catcagacag ggccagttta caaaagaaca tcataggatc aagtcctgtt gcagatttct   1080

ctgctattaa ggaactagat actcttaaca atgaaatagt tgacctacag agggaaaaga   1140

ataatgtgga acaggacctt aaggagaagg aagatactat taaacagagg acaagtgagg   1200

ttcaggatct tcaagatgaa gttcaaaggg agaatactaa tctgcaaaaa ctacaggccc   1260

agaaacagca ggtacaggaa ctccttgatg aactggatga gcagaaagcc cagctggagg   1320

agcaactcaa ggaagtcaga aagaaatgtg ctgaggaggc ccaactgatc tcttctctga   1380

aagctgaatt aactagtcag gaatcgcaga tctccactta cgaagaagaa ttggcaaaag   1440

ctagagaaga gctgagccgt ctacagcaag aaacagcaga attggaggag agtgtagagt   1500

cagggaaggc tcagttggaa cctcttcagc agcacctaca agattcacaa caggaaatta   1560

gttcaatgca aatgaaactg atggaaatga aagatttgga aaatcataat agtcagttaa   1620

attggtgcag tagcccacac agcattcttg taaacggagc tacagattat tgcagcctca   1680

gcaccagcag cagtgaaaca gccaacctta atgaacatgt tgaaggccag agcaacctag   1740

agtctgagcc catacaccag gaatctccag caagaagtag tcctgaacta ctgccttctg   1800

gtgtgactga tgaaaatgag gtgactacag ctgttactga aaaagtttgt tctgaactcg   1860

acaataatag acattcaaaa gaggaagatc catttaatgt agactcaagt tcgctgacag   1920

gtccagttgc agatacaaac ttggattttt tccagtctga tccttttgtt ggcagtgatc   1980

ctttcaagga tgatcctttt ggaaaaatcg atccatttgg tggtgatcct ttcaaaggtt   2040

cagatccatt tgcatcagac tgtttcttca ggcaatctac tgatcctttt gccacttcaa   2100

gcactgaccc tttcagtgca gccaacaata gcagtattac atcggtagaa acgttgaagc   2160

acaatgatcc ttttgctcct ggtggaacag ttgttgcagc aagcgattca gccacagacc   2220

cctttgcttc tgtttttggg aatgaatcat ttggaggtgg atttgctgac ttcagcacat   2280

tgtcaaaggt caacaatgaa gatccttttc gttcagccac atcgagctct gtcagcaacg   2340

tagtgattac aaaaaatgta tttgaggaaa catcggtcaa aagtgaagat gaacccccag   2400

cactgccacc aaagatcgga actccaacaa gaccctgccc tctaccacct gggaaaagat   2460

ccatcaacaa attggattct cctgatccct ttaaactgaa tgatccattt cagcctttcc   2520

caggcaacga tagccccaaa gaaaaagatc ctgaaatatt ttgtgatcca ttcacttctg   2580

ctactaccac taccaataaa gaggctgatc caagcaattt tgccaacttc agtgcttatc   2640

cctctgaaga agatatgatc gaatgggcca agagggaaag tgagagagag gaagagcaga   2700

ggcttgcccg actaaatcag caggaacaag aagacttaga actggctatt gcactcagca   2760

aatctgagat atcagaagca tgaagaattc tcttgttctt tggcaacaat atagtattct   2820

tcttcctgaa tactgaaact atttacaatg tgtatcaaaa ctacctgtga gcatgggaat   2880

acaaaaggtt tgagattcct gtaaatgtga caaaatttta ggattttttt tttttcttca   2940

ttacagattc gtcttttttt ttttttctta taaaagccgt aacccagtca gacaaattca   3000

ccttcactta ggcccctgtt ctggtataca tttactgtga gcttttgcct gcctgtgcta   3060

ttttacttgt aaagctagag cacccaagct tctgccttct ggaatataga gaaatagttt   3120

caccctgcac taccctgttc tgtagttatt ctgatgatag ccagtgaggt tcttaaagtt   3180

tgcagtattc tcccctgatt ggaatggttg agtgagggta agggaaagaa tatcttattt   3240

cttttatgat tggtgcaaat tggctaaagt gcatttttaa atttcctcta cttaatttgt   3300

ttttcagaga taaggaaaaa tattttgcac agatttactc cactatggaa aagggatgct   3360

gtaggttgaa ccattatagc ctcagattcg atcttttcct aactaaaaat attaaagcct   3420

catgtgtgaa ataaattttt aaaaagattt atctggattt agagaatttt agatcaacag   3480

atacctctca gtgtgtttgc taattaataa aaatcagttt cttacaaata aagtttgtaa   3540

gaaaatgttc attttaagtg atagatagtg gagaaaattt atcacctaaa atatacccat   3600

cagtataagg caagcaaaag tcttaacatg gcagccattc tgcctttgcc gtggccctgt   3660

cctgtttagt tcttagtggg ttaatttttg tacttttgca gaagaaactt cagcaagcta   3720

gaactggaag gtactttaat ttttcatata tatttgtttt ttttttttta atgaaggctc   3780

atttacttga aatgtaaaaa ctttcactga atacaaatag aaaaagtgat gtgttttata   3840

tcatattgct ttttgtccat ctttgtggtt tagtttattt actcacttca tgtttttcac   3900

ctataaaatt gtcaagctag caaaaaaact cttgtttttt taattgggag agaagagacc   3960

tgccagatta tcagacctct tcatgttaaa agaccatctc ctgtaaaact gacctagtgg   4020

acaagctgaa tttgaaatag actgtgaagt aagctgtaac ttgtcatttt aattttgttt   4080

aacacggtta ctgacttaga tgatgtatta aataccaaga taaagaaaaa tgcacctaaa   4140

atctaattag aattctctgg gtcaacaagt caaggtggta ttgatctgtg ttaatctgag   4200

taacttattg cctagcctat aaataaattc caaaatatcc aattcatttc ttcttgaaat   4260

ggtgcttgtt ttgttttctt tccattacac aattagactc ctacagttta aaacaaactt   4320

taaaccacta tcttgcactg ctaacttttt tctacctttg taaatagaaa catttctgca   4380

taaaagtcat acatatgaag caagggctga atcataatca caaggcttaa ttttgataaa   4440

cgaatccagt gacctaagga ttttctgcaa aatttgactg ggagttgtga taggtggtat   4500

ttttgtttat tttcttcctc ttactcctta ggataaaggt aagttgactt gaacaacttt   4560

cttttgcact gggaaaataa gcaaatgttt aaatgcttca aaaaaatttt caattaaact   4620

caaatattaa atatctataa cttataaaca ccaactttca atgtaataaa tgtatcctaa   4680

tcttatgtat gtttaactgg attacataga tttttatctt ttgttaaaat gtgtataccc   4740

cgtggaccaa cataatatta aagtatgtat atattatata aatatatatg tatatgtgct   4800

cgcttgtgta ggatgaatgt cttagagtcg tttgtggtat tttatgttgt tgactctggc   4860

tccagggcct gtgcttgaaa aggacagata agtattgccc agagctaagt ggcactactt   4920

acaaagtttt aaatgtcttc tacatactga ttcatgttta tttgagctct ctttatagaa   4980

ttttctctta aagtttcaaa cctctaagtt gtagcctgta attatgagaa cagtaaactt   5040

taagtaataa taaagaatcc catccatata tccaatttg                          5079


<210>  6322
<211>  896
<212>  PRT
<213>  Homosapiens

<400>  6322

Met Ala Ala Ala Ala Gln Leu Ser Leu Thr Gln Leu Ser Ser Gly Asn 
1               5                   10                  15      


Pro Val Tyr Glu Lys Tyr Tyr Arg Gln Val Asp Thr Gly Asn Thr Gly 
            20                  25                  30          


Arg Val Leu Ala Ser Asp Ala Ala Ala Phe Leu Lys Lys Ser Gly Leu 
        35                  40                  45              


Pro Asp Leu Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Thr Asp Gly 
    50                  55                  60                  


Lys Gly Ile Leu Asn Lys Gln Glu Phe Phe Val Ala Leu Arg Leu Val 
65                  70                  75                  80  


Ala Cys Ala Gln Asn Gly Leu Glu Val Ser Leu Ser Ser Leu Asn Leu 
                85                  90                  95      


Ala Val Pro Pro Pro Arg Phe His Asp Thr Ser Ser Pro Leu Leu Ile 
            100                 105                 110         


Ser Gly Thr Ser Ala Ala Glu Leu Pro Trp Ala Val Lys Pro Glu Asp 
        115                 120                 125             


Lys Ala Lys Tyr Asp Ala Ile Phe Asp Ser Leu Ser Pro Val Asn Gly 
    130                 135                 140                 


Phe Leu Ser Gly Asp Lys Val Lys Pro Val Leu Leu Asn Ser Lys Leu 
145                 150                 155                 160 


Pro Val Asp Ile Leu Gly Arg Val Trp Glu Leu Ser Asp Ile Asp His 
                165                 170                 175     


Asp Gly Met Leu Asp Arg Asp Glu Phe Ala Val Ala Met Phe Leu Val 
            180                 185                 190         


Tyr Cys Ala Leu Glu Lys Glu Pro Val Pro Met Ser Leu Pro Pro Ala 
        195                 200                 205             


Leu Val Pro Pro Ser Lys Arg Lys Thr Trp Val Val Ser Pro Ala Glu 
    210                 215                 220                 


Lys Ala Lys Tyr Asp Glu Ile Phe Leu Lys Thr Asp Lys Asp Met Asp 
225                 230                 235                 240 


Gly Phe Val Ser Gly Leu Glu Val Arg Glu Ile Phe Leu Lys Thr Gly 
                245                 250                 255     


Leu Pro Ser Thr Leu Leu Ala His Ile Trp Ser Leu Cys Asp Thr Lys 
            260                 265                 270         


Asp Cys Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala Phe His Leu 
        275                 280                 285             


Ile Ser Gln Lys Leu Ile Lys Gly Ile Asp Pro Pro His Val Leu Thr 
    290                 295                 300                 


Pro Glu Met Ile Pro Pro Ser Asp Arg Ala Ser Leu Gln Lys Asn Ile 
305                 310                 315                 320 


Ile Gly Ser Ser Pro Val Ala Asp Phe Ser Ala Ile Lys Glu Leu Asp 
                325                 330                 335     


Thr Leu Asn Asn Glu Ile Val Asp Leu Gln Arg Glu Lys Asn Asn Val 
            340                 345                 350         


Glu Gln Asp Leu Lys Glu Lys Glu Asp Thr Ile Lys Gln Arg Thr Ser 
        355                 360                 365             


Glu Val Gln Asp Leu Gln Asp Glu Val Gln Arg Glu Asn Thr Asn Leu 
    370                 375                 380                 


Gln Lys Leu Gln Ala Gln Lys Gln Gln Val Gln Glu Leu Leu Asp Glu 
385                 390                 395                 400 


Leu Asp Glu Gln Lys Ala Gln Leu Glu Glu Gln Leu Lys Glu Val Arg 
                405                 410                 415     


Lys Lys Cys Ala Glu Glu Ala Gln Leu Ile Ser Ser Leu Lys Ala Glu 
            420                 425                 430         


Leu Thr Ser Gln Glu Ser Gln Ile Ser Thr Tyr Glu Glu Glu Leu Ala 
        435                 440                 445             


Lys Ala Arg Glu Glu Leu Ser Arg Leu Gln Gln Glu Thr Ala Glu Leu 
    450                 455                 460                 


Glu Glu Ser Val Glu Ser Gly Lys Ala Gln Leu Glu Pro Leu Gln Gln 
465                 470                 475                 480 


His Leu Gln Asp Ser Gln Gln Glu Ile Ser Ser Met Gln Met Lys Leu 
                485                 490                 495     


Met Glu Met Lys Asp Leu Glu Asn His Asn Ser Gln Leu Asn Trp Cys 
            500                 505                 510         


Ser Ser Pro His Ser Ile Leu Val Asn Gly Ala Thr Asp Tyr Cys Ser 
        515                 520                 525             


Leu Ser Thr Ser Ser Ser Glu Thr Ala Asn Leu Asn Glu His Val Glu 
    530                 535                 540                 


Gly Gln Ser Asn Leu Glu Ser Glu Pro Ile His Gln Glu Ser Pro Ala 
545                 550                 555                 560 


Arg Ser Ser Pro Glu Leu Leu Pro Ser Gly Val Thr Asp Glu Asn Glu 
                565                 570                 575     


Val Thr Thr Ala Val Thr Glu Lys Val Cys Ser Glu Leu Asp Asn Asn 
            580                 585                 590         


Arg His Ser Lys Glu Glu Asp Pro Phe Asn Val Asp Ser Ser Ser Leu 
        595                 600                 605             


Thr Gly Pro Val Ala Asp Thr Asn Leu Asp Phe Phe Gln Ser Asp Pro 
    610                 615                 620                 


Phe Val Gly Ser Asp Pro Phe Lys Asp Asp Pro Phe Gly Lys Ile Asp 
625                 630                 635                 640 


Pro Phe Gly Gly Asp Pro Phe Lys Gly Ser Asp Pro Phe Ala Ser Asp 
                645                 650                 655     


Cys Phe Phe Arg Gln Ser Thr Asp Pro Phe Ala Thr Ser Ser Thr Asp 
            660                 665                 670         


Pro Phe Ser Ala Ala Asn Asn Ser Ser Ile Thr Ser Val Glu Thr Leu 
        675                 680                 685             


Lys His Asn Asp Pro Phe Ala Pro Gly Gly Thr Val Val Ala Ala Ser 
    690                 695                 700                 


Asp Ser Ala Thr Asp Pro Phe Ala Ser Val Phe Gly Asn Glu Ser Phe 
705                 710                 715                 720 


Gly Gly Gly Phe Ala Asp Phe Ser Thr Leu Ser Lys Val Asn Asn Glu 
                725                 730                 735     


Asp Pro Phe Arg Ser Ala Thr Ser Ser Ser Val Ser Asn Val Val Ile 
            740                 745                 750         


Thr Lys Asn Val Phe Glu Glu Thr Ser Val Lys Ser Glu Asp Glu Pro 
        755                 760                 765             


Pro Ala Leu Pro Pro Lys Ile Gly Thr Pro Thr Arg Pro Cys Pro Leu 
    770                 775                 780                 


Pro Pro Gly Lys Arg Ser Ile Asn Lys Leu Asp Ser Pro Asp Pro Phe 
785                 790                 795                 800 


Lys Leu Asn Asp Pro Phe Gln Pro Phe Pro Gly Asn Asp Ser Pro Lys 
                805                 810                 815     


Glu Lys Asp Pro Glu Ile Phe Cys Asp Pro Phe Thr Ser Ala Thr Thr 
            820                 825                 830         


Thr Thr Asn Lys Glu Ala Asp Pro Ser Asn Phe Ala Asn Phe Ser Ala 
        835                 840                 845             


Tyr Pro Ser Glu Glu Asp Met Ile Glu Trp Ala Lys Arg Glu Ser Glu 
    850                 855                 860                 


Arg Glu Glu Glu Gln Arg Leu Ala Arg Leu Asn Gln Gln Glu Gln Glu 
865                 870                 875                 880 


Asp Leu Glu Leu Ala Ile Ala Leu Ser Lys Ser Glu Ile Ser Glu Ala 
                885                 890                 895     


<210>  6323
<211>  3893
<212>  DNA
<213>  Homosapiens

<400>  6323
tcctttttta atctatcctc ttttcaccac attttagtga gaaagcaatt ttttttttac     60

aaatggagct tatattgatt tttatttcat aaataattga aagagggtag aaaaatctgc    120

ccttcattta aaaattgaat gtttcactat gtatttaaaa agcgattcag gattaggagg    180

atggataacc ataccagctg tagctgatgt tctaaaatat tcttgcattg tttgctggtc    240

ttctagggaa aagaataatg tggaacagga ccttaaggag aaggaagata ctattaaaca    300

gaggacaagt gaggttcagg atcttcaaga tgaagttcaa agggagaata ctaatctgca    360

aaaactacag gcccagaaac agcaggtaca ggaactcctt gatgaactgg atgagcagaa    420

agcccagctg gaggagcaac tcaaggaagt cagaaagaaa tgtgctgagg aggcccaact    480

gatctcttct ctgaaagctg aattaactag tcaggaatcg cagatctcca cttacgaaga    540

agaattggca aaagctagag aagagctgag ccgtctacag caagaaacag cagaattgga    600

ggagagtgta gagtcaggga aggctcagtt ggaacctctt cagcagcacc tacaagattc    660

acaacaggaa attagttcaa tgcaaatgaa actgatggaa atgaaagatt tggaaaatca    720

taatagtcag ttaaattggt gcagtagccc acacagcatt cttgtaaacg gagctacaga    780

ttattgcagc ctcagcacca gcagcagtga aacagccaac cttaatgaac atgttgaagg    840

ccagagcaac ctagagtctg agcccataca ccaggaatct ccagcaagaa gtagtcctga    900

actactgcct tctggtgtga ctgatgaaaa tgaggtgact acagctgtta ctgaaaaagt    960

ttgttctgaa ctcgacaata atagacattc aaaagaggaa gatccattta atgtagactc   1020

aagttcgctg acaggtccag ttgcagatac aaacttggat tttttccagt ctgatccttt   1080

tgttggcagt gatcctttca aggatgatcc ttttggaaaa atcgatccat ttggtggtga   1140

tcctttcaaa ggttcagatc catttgcatc agactgtttc ttcaggcaat ctactgatcc   1200

ttttgccact tcaagcactg accctttcag tgcagccaac aatagcagta ttacatcggt   1260

agaaacgttg aagcacaatg atccttttgc tcctggtgga acagttgttg cagcaagcga   1320

ttcagccaca gacccctttg cttctgtttt tgggaatgaa tcatttggag gtggatttgc   1380

tgacttcagc acattgtcaa aggtcaacaa tgaagatcct tttcgttcag ccacatcgag   1440

ctctgtcagc aacgtagtga ttacaaaaaa tgtatttgag gaaacatcgg tcaaaagtga   1500

agatgaaccc ccagcactgc caccaaagat cggaactcca acaagaccct gccctctacc   1560

acctgggaaa agatccatca acaaattgga ttctcctgat ccctttaaac tgaatgatcc   1620

atttcagcct ttcccaggca acgatagccc caaagaaaaa gatcctgaaa tattttgtga   1680

tccattcact tctgctacta ccactaccaa taaagaggct gatccaagca attttgccaa   1740

cttcagtgct tatccctctg aagaagatat gatcgaatgg gccaagaggg aaagtgagag   1800

agaggaagag cagaggcttg cccgactaaa tcagcaggaa caagaagact tagaactggc   1860

tattgcactc agcaaatctg agatatcaga agcatgaaga attctcttgt tctttggcaa   1920

caatatagta ttcttcttcc tgaatactga aactatttac aatgtgtatc aaaactacct   1980

gtgagcatgg gaatacaaaa ggtttgagat tcctgtaaat gtgacaaaat tttaggattt   2040

tttttttttc ttcattacag attcgtcttt tttttttttt cttataaaag ccgtaaccca   2100

gtcagacaaa ttcaccttca cttaggcccc tgttctggta tacatttact gtgagctttt   2160

gcctgcctgt gctattttac ttgtaaagct agagcaccca agcttctgcc ttctggaata   2220

tagagaaata gtttcaccct gcactaccct gttctgtagt tattctgatg atagccagtg   2280

aggttcttaa agtttgcagt attctcccct gattggaatg gttgagtgag ggtaagggaa   2340

agaatatctt atttctttta tgattggtgc aaattggcta aagtgcattt ttaaatttcc   2400

tctacttaat ttgtttttca gagataagga aaaatatttt gcacagattt actccactat   2460

ggaaaaggga tgctgtaggt tgaaccatta tagcctcaga ttcgatcttt tcctaactaa   2520

aaatattaaa gcctcatgtg tgaaataaat ttttaaaaag atttatctgg atttagagaa   2580

ttttagatca acagatacct ctcagtgtgt ttgctaatta ataaaaatca gtttcttaca   2640

aataaagttt gtaagaaaat gttcatttta agtgatagat agtggagaaa atttatcacc   2700

taaaatatac ccatcagtat aaggcaagca aaagtcttaa catggcagcc attctgcctt   2760

tgccgtggcc ctgtcctgtt tagttcttag tgggttaatt tttgtacttt tgcagaagaa   2820

acttcagcaa gctagaactg gaaggtactt taatttttca tatatatttg tttttttttt   2880

tttaatgaag gctcatttac ttgaaatgta aaaactttca ctgaatacaa atagaaaaag   2940

tgatgtgttt tatatcatat tgctttttgt ccatctttgt ggtttagttt atttactcac   3000

ttcatgtttt tcacctataa aattgtcaag ctagcaaaaa aactcttgtt tttttaattg   3060

ggagagaaga gacctgccag attatcagac ctcttcatgt taaaagacca tctcctgtaa   3120

aactgaccta gtggacaagc tgaatttgaa atagactgtg aagtaagctg taacttgtca   3180

ttttaatttt gtttaacacg gttactgact tagatgatgt attaaatacc aagataaaga   3240

aaaatgcacc taaaatctaa ttagaattct ctgggtcaac aagtcaaggt ggtattgatc   3300

tgtgttaatc tgagtaactt attgcctagc ctataaataa attccaaaat atccaattca   3360

tttcttcttg aaatggtgct tgttttgttt tctttccatt acacaattag actcctacag   3420

tttaaaacaa actttaaacc actatcttgc actgctaact tttttctacc tttgtaaata   3480

gaaacatttc tgcataaaag tcatacatat gaagcaaggg ctgaatcata atcacaaggc   3540

ttaattttga taaacgaatc cagtgaccta aggattttct gcaaaatttg actgggagtt   3600

gtgataggtg gtatttttgt ttattttctt cctcttactc cttaggataa aggtaagttg   3660

acttgaacaa ctttcttttg cactgggaaa ataagcaaat gtttaaatgc ttcaaaaaaa   3720

ttttcaatta aactcaaata ttaaatatct ataacttata aacaccaact ttcaatgtaa   3780

taaatgtatc ctaatcttat gtatgtttaa ctggattaca tagattttta tcttttgtta   3840

aaatgtgtat accccgtgga ccaacataat attaaagtat gtatatatta tat          3893


<210>  6324
<211>  582
<212>  PRT
<213>  Homosapiens

<400>  6324

Met Tyr Leu Lys Ser Asp Ser Gly Leu Gly Gly Trp Ile Thr Ile Pro 
1               5                   10                  15      


Ala Val Ala Asp Val Leu Lys Tyr Ser Cys Ile Val Cys Trp Ser Ser 
            20                  25                  30          


Arg Glu Lys Asn Asn Val Glu Gln Asp Leu Lys Glu Lys Glu Asp Thr 
        35                  40                  45              


Ile Lys Gln Arg Thr Ser Glu Val Gln Asp Leu Gln Asp Glu Val Gln 
    50                  55                  60                  


Arg Glu Asn Thr Asn Leu Gln Lys Leu Gln Ala Gln Lys Gln Gln Val 
65                  70                  75                  80  


Gln Glu Leu Leu Asp Glu Leu Asp Glu Gln Lys Ala Gln Leu Glu Glu 
                85                  90                  95      


Gln Leu Lys Glu Val Arg Lys Lys Cys Ala Glu Glu Ala Gln Leu Ile 
            100                 105                 110         


Ser Ser Leu Lys Ala Glu Leu Thr Ser Gln Glu Ser Gln Ile Ser Thr 
        115                 120                 125             


Tyr Glu Glu Glu Leu Ala Lys Ala Arg Glu Glu Leu Ser Arg Leu Gln 
    130                 135                 140                 


Gln Glu Thr Ala Glu Leu Glu Glu Ser Val Glu Ser Gly Lys Ala Gln 
145                 150                 155                 160 


Leu Glu Pro Leu Gln Gln His Leu Gln Asp Ser Gln Gln Glu Ile Ser 
                165                 170                 175     


Ser Met Gln Met Lys Leu Met Glu Met Lys Asp Leu Glu Asn His Asn 
            180                 185                 190         


Ser Gln Leu Asn Trp Cys Ser Ser Pro His Ser Ile Leu Val Asn Gly 
        195                 200                 205             


Ala Thr Asp Tyr Cys Ser Leu Ser Thr Ser Ser Ser Glu Thr Ala Asn 
    210                 215                 220                 


Leu Asn Glu His Val Glu Gly Gln Ser Asn Leu Glu Ser Glu Pro Ile 
225                 230                 235                 240 


His Gln Glu Ser Pro Ala Arg Ser Ser Pro Glu Leu Leu Pro Ser Gly 
                245                 250                 255     


Val Thr Asp Glu Asn Glu Val Thr Thr Ala Val Thr Glu Lys Val Cys 
            260                 265                 270         


Ser Glu Leu Asp Asn Asn Arg His Ser Lys Glu Glu Asp Pro Phe Asn 
        275                 280                 285             


Val Asp Ser Ser Ser Leu Thr Gly Pro Val Ala Asp Thr Asn Leu Asp 
    290                 295                 300                 


Phe Phe Gln Ser Asp Pro Phe Val Gly Ser Asp Pro Phe Lys Asp Asp 
305                 310                 315                 320 


Pro Phe Gly Lys Ile Asp Pro Phe Gly Gly Asp Pro Phe Lys Gly Ser 
                325                 330                 335     


Asp Pro Phe Ala Ser Asp Cys Phe Phe Arg Gln Ser Thr Asp Pro Phe 
            340                 345                 350         


Ala Thr Ser Ser Thr Asp Pro Phe Ser Ala Ala Asn Asn Ser Ser Ile 
        355                 360                 365             


Thr Ser Val Glu Thr Leu Lys His Asn Asp Pro Phe Ala Pro Gly Gly 
    370                 375                 380                 


Thr Val Val Ala Ala Ser Asp Ser Ala Thr Asp Pro Phe Ala Ser Val 
385                 390                 395                 400 


Phe Gly Asn Glu Ser Phe Gly Gly Gly Phe Ala Asp Phe Ser Thr Leu 
                405                 410                 415     


Ser Lys Val Asn Asn Glu Asp Pro Phe Arg Ser Ala Thr Ser Ser Ser 
            420                 425                 430         


Val Ser Asn Val Val Ile Thr Lys Asn Val Phe Glu Glu Thr Ser Val 
        435                 440                 445             


Lys Ser Glu Asp Glu Pro Pro Ala Leu Pro Pro Lys Ile Gly Thr Pro 
    450                 455                 460                 


Thr Arg Pro Cys Pro Leu Pro Pro Gly Lys Arg Ser Ile Asn Lys Leu 
465                 470                 475                 480 


Asp Ser Pro Asp Pro Phe Lys Leu Asn Asp Pro Phe Gln Pro Phe Pro 
                485                 490                 495     


Gly Asn Asp Ser Pro Lys Glu Lys Asp Pro Glu Ile Phe Cys Asp Pro 
            500                 505                 510         


Phe Thr Ser Ala Thr Thr Thr Thr Asn Lys Glu Ala Asp Pro Ser Asn 
        515                 520                 525             


Phe Ala Asn Phe Ser Ala Tyr Pro Ser Glu Glu Asp Met Ile Glu Trp 
    530                 535                 540                 


Ala Lys Arg Glu Ser Glu Arg Glu Glu Glu Gln Arg Leu Ala Arg Leu 
545                 550                 555                 560 


Asn Gln Gln Glu Gln Glu Asp Leu Glu Leu Ala Ile Ala Leu Ser Lys 
                565                 570                 575     


Ser Glu Ile Ser Glu Ala 
            580         


<210>  6325
<211>  4779
<212>  DNA
<213>  Homosapiens

<400>  6325
ggcctcgcct gcggccgctc cctccgcctc ctccccgccc cgagccccag tcagcccgtc     60

ttccttcccc tcccttgcat gatggaaaca ccatggctgc ggcggcccag ctctctctga    120

cacagttatc aagtgggaat cctgtatatg aaaaatacta tagacaggtt gatacaggca    180

atactggaag ggtgttggct tctgatgctg ctgctttcct gaaaaaatca gggcttccag    240

acttgatact tggaaagatt tgggatttag ccgacacaga tggcaaaggt atcctgaaca    300

aacaagaatt ctttgttgct ttgcgtcttg tggcatgtgc ccagaatgga ttggaagttt    360

cactaagtag tttgaacctg gctgttcctc caccaagatt tcatgatacc agtagtcctt    420

tgctaatcag tggaacctct gcagctgagc tcccatgggc tgtaaaacct gaagataagg    480

ccaaatatga tgcaatattt gatagtttaa gcccagtgaa tggatttctg tctggtgata    540

aagtgaaacc agtgttgctc aactctaagt tacctgtgga tatccttgga agagtttggg    600

agttgagtga tattgaccat gatggaatgc ttgacagaga tgagtttgca gttgccatgt    660

ttttggtata ctgtgcactg gagaaagaac ctgtgccaat gtccttgcct ccagccttgg    720

tgccaccatc taagagaaaa acgtgggttg tatcccctgc agaaaaagct aaatatgatg    780

aaatcttcct gaaaactgat aaagatatgg acggatttgt gtctggattg gaggtccgtg    840

aaatattctt gaaaacaggt ttaccttcta ccttactagc ccatatatgg tcattatgcg    900

acacaaagga ctgtgggaag ctttcaaagg atcagtttgc cttggctttt cacttaatca    960

gtcagaagtt aatcaagggc attgatcctc ctcacgttct tactcctgaa atgattccac   1020

catcagacag ggccagttta caaaagaaca tcataggatc aagtcctgtt gcagatttct   1080

ctgctattaa ggaactagat actcttaaca atgaaatagt tgacctacag agggaaaaga   1140

ataatgtgga acaggacctt aaggagaagg aagatactat taaacagagg acaagtgagg   1200

ttcaggatct tcaagatgaa gttcaaaggg agaatactaa tctgcaaaaa ctacaggccc   1260

agaaacagca ggtacaggaa ctccttgatg aactggatga gcagaaagcc cagctggagg   1320

agcaactcaa ggaagtcaga aagaaatgtg ctgaggaggc ccaactgatc tcttctctga   1380

aagctgaatt aactagtcag gaatcgcaga tctccactta cgaagaagaa ttggcaaaag   1440

ctagagaaga gctgagccgt ctacagcaag aaacagcaga attggaggag agtgtagagt   1500

cagggaaggc tcagttggaa cctcttcagc agcacctaca agattcacaa caggaaatta   1560

gttcaatgca aatgaaactg atggaaatga aagatttgga aaatcataat agtcagttaa   1620

attggtgcag tagcccacac agcattcttg taaacggagc tacagattat tgcagcctca   1680

gcaccagcag cagtgaaaca gccaacctta atgaacatgt tgaaggccag agcaacctag   1740

agtctgagcc catacaccag gaatctccag caagaagtag tcctgaacta ctgccttctg   1800

gtgtgactga tgaaaatgag gtgactacag ctgttactga aaaagtttgt tctgaactcg   1860

acaataatag acattcaaaa gaggaagatc catttaatgt agactcaagt tcgctgacag   1920

gtccagttgc agatacaaac ttggattttt tccagtctga tccttttgtt ggcagtgatc   1980

ctttcaagga tgatcctttt ggaaaaatcg atccatttgg tggtgatcct ttcaaaggtt   2040

cagatccatt tgcatcagac tgtttcttca ggcaatctac tgatcctttt gccacttcaa   2100

gcactgaccc tttcagtgca gccaacaata gcagtattac atcggtagaa acgttgaagc   2160

acaatgatcc ttttgctcct ggtggaacag ttgttgcagc aagcgattca gccacagacc   2220

cctttgcttc tgtttttggg aatgaatcat ttggaggtgg atttgctgac ttcagcacat   2280

tgtcaaaggt caacaatgaa gatccttttc gttcagccac atcgagctct gtcagcaacg   2340

tagtgattac aaaaaatgta tttgaggaaa catcggtcaa aagtgaagat gaacccccag   2400

cactgccacc aaagatcgga actccaacaa gaccctgccc tctaccacct gggaaaagat   2460

ccatcaacaa attggattct cctgatccct ttaaactgaa tgatccattt cagcctttcc   2520

caggcaacga tagccccaaa gaaaaagatc ctgaaatatt ttgtgatcca ttcacttctg   2580

ctactaccac taccaataaa gaggctgatc caagcaattt tgccaacttc agtgcttatc   2640

cctctgaaga agatatgatc gaatgggcca agagggaaag tgagagagag gaagagcaga   2700

ggcttgcccg actaaatcag caggaacaag aagacttaga actggctatt gcactcagca   2760

aatctgagat atcagaagca tgaagaattc tcttgttctt tggcaacaat atagtattct   2820

tcttcctgaa tactgaaact atttacaatg tgtatcaaaa ctacctgtga gcatgggaat   2880

acaaaaggtt tgagattcct gtaaatgtga caaaatttta ggattttttt tttttcttca   2940

ttacagattc gtcttttttt ttttttctta taaaagccgt aacccagtca gacaaattca   3000

ccttcactta ggcccctgtt ctggtataca tttactgtga gcttttgcct gcctgtgcta   3060

ttttacttgt aaagctagag cacccaagct tctgccttct ggaatataga gaaatagttt   3120

caccctgcac taccctgttc tgtagttatt ctgatgatag ccagtgaggt tcttaaagtt   3180

tgcagtattc tcccctgatt ggaatggttg agtgagggta agggaaagaa tatcttattt   3240

cttttatgat tggtgcaaat tggctaaagt gcatttttaa atttcctcta cttaatttgt   3300

ttttcagaga taaggaaaaa tattttgcac agatttactc cactatggaa aagggatgct   3360

gtaggttgaa ccattatagc ctcagattcg atcttttcct aactaaaaat attaaagcct   3420

catgtgtgaa ataaattttt aaaaagattt atctggattt agagaatttt agatcaacag   3480

atacctctca gtgtgtttgc taattaataa aaatcagttt cttacaaata aagtttgtaa   3540

gaaaatgttc attttaagtg atagatagtg gagaaaattt atcacctaaa atatacccat   3600

cagtataagg caagcaaaag tcttaacatg gcagccattc tgcctttgcc gtggccctgt   3660

cctgtttagt tcttagtggg ttaatttttg tacttttgca gaagaaactt cagcaagcta   3720

gaactggaag gtactttaat ttttcatata tatttgtttt ttttttttta atgaaggctc   3780

atttacttga aatgtaaaaa ctttcactga atacaaatag aaaaagtgat gtgttttata   3840

tcatattgct ttttgtccat ctttgtggtt tagtttattt actcacttca tgtttttcac   3900

ctataaaatt gtcaagctag caaaaaaact cttgtttttt taattgggag agaagagacc   3960

tgccagatta tcagacctct tcatgttaaa agaccatctc ctgtaaaact gacctagtgg   4020

acaagctgaa tttgaaatag actgtgaagt aagctgtaac ttgtcatttt aattttgttt   4080

aacacggtta ctgacttaga tgatgtatta aataccaaga taaagaaaaa tgcacctaaa   4140

atctaattag aattctctgg gtcaacaagt caaggtggta ttgatctgtg ttaatctgag   4200

taacttattg cctagcctat aaataaattc caaaatatcc aattcatttc ttcttgaaat   4260

ggtgcttgtt ttgttttctt tccattacac aattagactc ctacagttta aaacaaactt   4320

taaaccacta tcttgcactg ctaacttttt tctacctttg taaatagaaa catttctgca   4380

taaaagtcat acatatgaag caagggctga atcataatca caaggcttaa ttttgataaa   4440

cgaatccagt gacctaagga ttttctgcaa aatttgactg ggagttgtga taggtggtat   4500

ttttgtttat tttcttcctc ttactcctta ggataaaggt aagttgactt gaacaacttt   4560

cttttgcact gggaaaataa gcaaatgttt aaatgcttca aaaaaatttt caattaaact   4620

caaatattaa atatctataa cttataaaca ccaactttca atgtaataaa tgtatcctaa   4680

tcttatgtat gtttaactgg attacataga tttttatctt ttgttaaaat gtgtataccc   4740

cgtggaccaa cataatatta aagtatgtat atattatat                          4779


<210>  6326
<211>  896
<212>  PRT
<213>  Homosapiens

<400>  6326

Met Ala Ala Ala Ala Gln Leu Ser Leu Thr Gln Leu Ser Ser Gly Asn 
1               5                   10                  15      


Pro Val Tyr Glu Lys Tyr Tyr Arg Gln Val Asp Thr Gly Asn Thr Gly 
            20                  25                  30          


Arg Val Leu Ala Ser Asp Ala Ala Ala Phe Leu Lys Lys Ser Gly Leu 
        35                  40                  45              


Pro Asp Leu Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Thr Asp Gly 
    50                  55                  60                  


Lys Gly Ile Leu Asn Lys Gln Glu Phe Phe Val Ala Leu Arg Leu Val 
65                  70                  75                  80  


Ala Cys Ala Gln Asn Gly Leu Glu Val Ser Leu Ser Ser Leu Asn Leu 
                85                  90                  95      


Ala Val Pro Pro Pro Arg Phe His Asp Thr Ser Ser Pro Leu Leu Ile 
            100                 105                 110         


Ser Gly Thr Ser Ala Ala Glu Leu Pro Trp Ala Val Lys Pro Glu Asp 
        115                 120                 125             


Lys Ala Lys Tyr Asp Ala Ile Phe Asp Ser Leu Ser Pro Val Asn Gly 
    130                 135                 140                 


Phe Leu Ser Gly Asp Lys Val Lys Pro Val Leu Leu Asn Ser Lys Leu 
145                 150                 155                 160 


Pro Val Asp Ile Leu Gly Arg Val Trp Glu Leu Ser Asp Ile Asp His 
                165                 170                 175     


Asp Gly Met Leu Asp Arg Asp Glu Phe Ala Val Ala Met Phe Leu Val 
            180                 185                 190         


Tyr Cys Ala Leu Glu Lys Glu Pro Val Pro Met Ser Leu Pro Pro Ala 
        195                 200                 205             


Leu Val Pro Pro Ser Lys Arg Lys Thr Trp Val Val Ser Pro Ala Glu 
    210                 215                 220                 


Lys Ala Lys Tyr Asp Glu Ile Phe Leu Lys Thr Asp Lys Asp Met Asp 
225                 230                 235                 240 


Gly Phe Val Ser Gly Leu Glu Val Arg Glu Ile Phe Leu Lys Thr Gly 
                245                 250                 255     


Leu Pro Ser Thr Leu Leu Ala His Ile Trp Ser Leu Cys Asp Thr Lys 
            260                 265                 270         


Asp Cys Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala Phe His Leu 
        275                 280                 285             


Ile Ser Gln Lys Leu Ile Lys Gly Ile Asp Pro Pro His Val Leu Thr 
    290                 295                 300                 


Pro Glu Met Ile Pro Pro Ser Asp Arg Ala Ser Leu Gln Lys Asn Ile 
305                 310                 315                 320 


Ile Gly Ser Ser Pro Val Ala Asp Phe Ser Ala Ile Lys Glu Leu Asp 
                325                 330                 335     


Thr Leu Asn Asn Glu Ile Val Asp Leu Gln Arg Glu Lys Asn Asn Val 
            340                 345                 350         


Glu Gln Asp Leu Lys Glu Lys Glu Asp Thr Ile Lys Gln Arg Thr Ser 
        355                 360                 365             


Glu Val Gln Asp Leu Gln Asp Glu Val Gln Arg Glu Asn Thr Asn Leu 
    370                 375                 380                 


Gln Lys Leu Gln Ala Gln Lys Gln Gln Val Gln Glu Leu Leu Asp Glu 
385                 390                 395                 400 


Leu Asp Glu Gln Lys Ala Gln Leu Glu Glu Gln Leu Lys Glu Val Arg 
                405                 410                 415     


Lys Lys Cys Ala Glu Glu Ala Gln Leu Ile Ser Ser Leu Lys Ala Glu 
            420                 425                 430         


Leu Thr Ser Gln Glu Ser Gln Ile Ser Thr Tyr Glu Glu Glu Leu Ala 
        435                 440                 445             


Lys Ala Arg Glu Glu Leu Ser Arg Leu Gln Gln Glu Thr Ala Glu Leu 
    450                 455                 460                 


Glu Glu Ser Val Glu Ser Gly Lys Ala Gln Leu Glu Pro Leu Gln Gln 
465                 470                 475                 480 


His Leu Gln Asp Ser Gln Gln Glu Ile Ser Ser Met Gln Met Lys Leu 
                485                 490                 495     


Met Glu Met Lys Asp Leu Glu Asn His Asn Ser Gln Leu Asn Trp Cys 
            500                 505                 510         


Ser Ser Pro His Ser Ile Leu Val Asn Gly Ala Thr Asp Tyr Cys Ser 
        515                 520                 525             


Leu Ser Thr Ser Ser Ser Glu Thr Ala Asn Leu Asn Glu His Val Glu 
    530                 535                 540                 


Gly Gln Ser Asn Leu Glu Ser Glu Pro Ile His Gln Glu Ser Pro Ala 
545                 550                 555                 560 


Arg Ser Ser Pro Glu Leu Leu Pro Ser Gly Val Thr Asp Glu Asn Glu 
                565                 570                 575     


Val Thr Thr Ala Val Thr Glu Lys Val Cys Ser Glu Leu Asp Asn Asn 
            580                 585                 590         


Arg His Ser Lys Glu Glu Asp Pro Phe Asn Val Asp Ser Ser Ser Leu 
        595                 600                 605             


Thr Gly Pro Val Ala Asp Thr Asn Leu Asp Phe Phe Gln Ser Asp Pro 
    610                 615                 620                 


Phe Val Gly Ser Asp Pro Phe Lys Asp Asp Pro Phe Gly Lys Ile Asp 
625                 630                 635                 640 


Pro Phe Gly Gly Asp Pro Phe Lys Gly Ser Asp Pro Phe Ala Ser Asp 
                645                 650                 655     


Cys Phe Phe Arg Gln Ser Thr Asp Pro Phe Ala Thr Ser Ser Thr Asp 
            660                 665                 670         


Pro Phe Ser Ala Ala Asn Asn Ser Ser Ile Thr Ser Val Glu Thr Leu 
        675                 680                 685             


Lys His Asn Asp Pro Phe Ala Pro Gly Gly Thr Val Val Ala Ala Ser 
    690                 695                 700                 


Asp Ser Ala Thr Asp Pro Phe Ala Ser Val Phe Gly Asn Glu Ser Phe 
705                 710                 715                 720 


Gly Gly Gly Phe Ala Asp Phe Ser Thr Leu Ser Lys Val Asn Asn Glu 
                725                 730                 735     


Asp Pro Phe Arg Ser Ala Thr Ser Ser Ser Val Ser Asn Val Val Ile 
            740                 745                 750         


Thr Lys Asn Val Phe Glu Glu Thr Ser Val Lys Ser Glu Asp Glu Pro 
        755                 760                 765             


Pro Ala Leu Pro Pro Lys Ile Gly Thr Pro Thr Arg Pro Cys Pro Leu 
    770                 775                 780                 


Pro Pro Gly Lys Arg Ser Ile Asn Lys Leu Asp Ser Pro Asp Pro Phe 
785                 790                 795                 800 


Lys Leu Asn Asp Pro Phe Gln Pro Phe Pro Gly Asn Asp Ser Pro Lys 
                805                 810                 815     


Glu Lys Asp Pro Glu Ile Phe Cys Asp Pro Phe Thr Ser Ala Thr Thr 
            820                 825                 830         


Thr Thr Asn Lys Glu Ala Asp Pro Ser Asn Phe Ala Asn Phe Ser Ala 
        835                 840                 845             


Tyr Pro Ser Glu Glu Asp Met Ile Glu Trp Ala Lys Arg Glu Ser Glu 
    850                 855                 860                 


Arg Glu Glu Glu Gln Arg Leu Ala Arg Leu Asn Gln Gln Glu Gln Glu 
865                 870                 875                 880 


Asp Leu Glu Leu Ala Ile Ala Leu Ser Lys Ser Glu Ile Ser Glu Ala 
                885                 890                 895     


<210>  6327
<211>  3111
<212>  DNA
<213>  Homosapiens

<400>  6327
agtgagaaag caattttttt tttacaaatg gagcttatat tgatttttat ttcataaata     60

attgaaagag ggtagaaaaa tctgcccttc atttaaaaat tgaatgtttc actatgtatt    120

taaaaagcga ttcaggatta ggaggatgga taaccatacc agctgtagct gatgttctaa    180

aatattcttg cattgtttgc tggtcttcta gggaaaagaa taatgtggaa caggacctta    240

aggagaagga agatactatt aaacagagga caagtgaggt tcaggatctt caagatgaag    300

ttcaaaggga gaatactaat ctgcaaaaac tacaggccca gaaacagcag gtacaggaac    360

tccttgatga actggatgag cagaaagccc agctggagga gcaactcaag gaattggcag    420

atgcaaatga aactgatgga aatgaaagat ttggaaaatc ataatagtca gttaaattgg    480

tgcagtagcc cacacagcat tcttgtaaac ggagctacag attattgcag cctcagcacc    540

agcagcagtg aaacagccaa ccttaatgaa catgttgaag gccagagcaa cctagagtct    600

gagcccatac accaggaatc tccagcaaga agtagtcctg aactactgcc ttctggtgtg    660

actgatgaaa atgaggtgac tacagctgtt actgaaaaag tttgttctga actcgacaat    720

aatagacatt caaaagagga agatccattt aatgtagact caagttcgct gacaggtcca    780

gttgcagata caaacttgga ttttttccag tctgatcctt ttgttggcag tgatcctttc    840

aaggatgatc cttttggaaa aatcgatcca tttggtggtg atcctttcaa aggttcagat    900

ccatttgcat cagactgttt cttcaggcaa tctactgatc cttttgccac ttcaagcact    960

gaccctttca gtgcagccaa caatagcagt attacatcgg tagaaacgtt gaagcacaat   1020

gatccttttg ctcctggtgg aacagttgtt gcagcaagcg attcagccac agaccccttt   1080

gcttctgttt ttgggaatga atcatttgga ggtggatttg ctgacttcag cacattgtca   1140

aaggtcaaca atgaagatcc ttttcgttca gccacatcga gctctgtcag caacgtagtg   1200

attacaaaaa atgtatttga ggaaacatcg gtcaaaagtg aagatgaacc cccagcactg   1260

ccaccaaaga tcggaactcc aacaagaccc tgccctctac cacctgggaa aagatccatc   1320

aacaaattgg attctcctga tccctttaaa ctgaatgatc catttcagcc tttcccaggc   1380

aacgatagcc ccaaagaaaa agatcctgaa atattttgtg atccattcac ttctgctact   1440

accactacca ataaagaggc tgatccaagc aattttgcca acttcagtgc ttatccctct   1500

gaagaagata tgatcgaatg ggccaagagg gaaagtgaga gagaggaaga gcagaggctt   1560

gcccgactaa atcagcagga acaagaagac ttagaactgg ctattgcact cagcaaatct   1620

gagatatcag aagcatgaag aattctcttg ttctttggca acaatatagt attcttcttc   1680

ctgaatactg aaactattta caatgtgtat caaaactacc tgtgagcatg ggaatacaaa   1740

aggtttgaga ttcctgtaaa tgtgacaaaa ttttaggatt tttttttttt cttcattaca   1800

gattcgtctt tttttttttt tcttataaaa gccgtaaccc agtcagacaa attcaccttc   1860

acttaggccc ctgttctggt atacatttac tgtgagcttt tgcctgcctg tgctatttta   1920

cttgtaaagc tagagcaccc aagcttctgc cttctggaat atagagaaat agtttcaccc   1980

tgcactaccc tgttctgtag ttattctgat gatagccagt gaggttctta aagtttgcag   2040

tattctcccc tgattggaat ggttgagtga gggtaaggga aagaatatct tatttctttt   2100

atgattggtg caaattggct aaagtgcatt tttaaatttc ctctacttaa tttgtttttc   2160

agagataagg aaaaatattt tgcacagatt tactccacta tggaaaaggg atgctgtagg   2220

ttgaaccatt atagcctcag attcgatctt ttcctaacta aaaatattaa agcctcatgt   2280

gtgaaataaa tttttaaaaa gatttatctg gatttagaga attttagatc aacagatacc   2340

tctcagtgtg tttgctaatt aataaaaatc agtttcttac aaataaagtt tgtaagaaaa   2400

tgttcatttt aagtgataga tagtggagaa aatttatcac ctaaaatata cccatcagta   2460

taaggcaagc aaaagtctta acatggcagc cattctgcct ttgccgtggc cctgtcctgt   2520

ttagttctta gtgggttaat ttttgtactt ttgcagaaga aacttcagca agctagaact   2580

ggaaggtact ttaatttttc atatatattt gttttttttt ttttaatgaa ggctcattta   2640

cttgaaatgt aaaaactttc actgaataca aatagaaaaa gtgatgtgtt ttatatcata   2700

ttgctttttg tccatctttg tggtttagtt tatttactca cttcatgttt ttcacctata   2760

aaattgtcaa gctagcaaaa aaactcttgt ttttttaatt gggagagaag agacctgcca   2820

gattatcaga cctcttcatg ttaaaagacc atctcctgta aaactgacct agtggacaag   2880

ctgaatttga aatagactgt gaagtaagct gtaacttgtc attttaattt tgtttaacac   2940

ggttactgac ttagatgatg tattaaatac caagataaag aaaaatgcac ctaaaatcta   3000

attagaattc tctgggtcaa caagtcaagg tggtattgat ctgtgttaat ctgagtaact   3060

tattgcctag cctataaata aattccaaaa tatccaattc atttcttctt g            3111


<210>  6328
<211>  471
<212>  PRT
<213>  Homosapiens

<400>  6328

Met Trp Asn Arg Thr Leu Arg Arg Arg Lys Ile Leu Leu Asn Arg Gly 
1               5                   10                  15      


Gln Val Arg Phe Arg Ile Phe Lys Met Lys Phe Lys Gly Arg Ile Leu 
            20                  25                  30          


Ile Cys Lys Asn Tyr Arg Pro Arg Asn Ser Arg Tyr Arg Asn Ser Leu 
        35                  40                  45              


Met Asn Trp Met Ser Arg Lys Pro Ser Trp Arg Ser Asn Ser Arg Asn 
    50                  55                  60                  


Trp Gln Met Gln Met Lys Leu Met Glu Met Lys Asp Leu Glu Asn His 
65                  70                  75                  80  


Asn Ser Gln Leu Asn Trp Cys Ser Ser Pro His Ser Ile Leu Val Asn 
                85                  90                  95      


Gly Ala Thr Asp Tyr Cys Ser Leu Ser Thr Ser Ser Ser Glu Thr Ala 
            100                 105                 110         


Asn Leu Asn Glu His Val Glu Gly Gln Ser Asn Leu Glu Ser Glu Pro 
        115                 120                 125             


Ile His Gln Glu Ser Pro Ala Arg Ser Ser Pro Glu Leu Leu Pro Ser 
    130                 135                 140                 


Gly Val Thr Asp Glu Asn Glu Val Thr Thr Ala Val Thr Glu Lys Val 
145                 150                 155                 160 


Cys Ser Glu Leu Asp Asn Asn Arg His Ser Lys Glu Glu Asp Pro Phe 
                165                 170                 175     


Asn Val Asp Ser Ser Ser Leu Thr Gly Pro Val Ala Asp Thr Asn Leu 
            180                 185                 190         


Asp Phe Phe Gln Ser Asp Pro Phe Val Gly Ser Asp Pro Phe Lys Asp 
        195                 200                 205             


Asp Pro Phe Gly Lys Ile Asp Pro Phe Gly Gly Asp Pro Phe Lys Gly 
    210                 215                 220                 


Ser Asp Pro Phe Ala Ser Asp Cys Phe Phe Arg Gln Ser Thr Asp Pro 
225                 230                 235                 240 


Phe Ala Thr Ser Ser Thr Asp Pro Phe Ser Ala Ala Asn Asn Ser Ser 
                245                 250                 255     


Ile Thr Ser Val Glu Thr Leu Lys His Asn Asp Pro Phe Ala Pro Gly 
            260                 265                 270         


Gly Thr Val Val Ala Ala Ser Asp Ser Ala Thr Asp Pro Phe Ala Ser 
        275                 280                 285             


Val Phe Gly Asn Glu Ser Phe Gly Gly Gly Phe Ala Asp Phe Ser Thr 
    290                 295                 300                 


Leu Ser Lys Val Asn Asn Glu Asp Pro Phe Arg Ser Ala Thr Ser Ser 
305                 310                 315                 320 


Ser Val Ser Asn Val Val Ile Thr Lys Asn Val Phe Glu Glu Thr Ser 
                325                 330                 335     


Val Lys Ser Glu Asp Glu Pro Pro Ala Leu Pro Pro Lys Ile Gly Thr 
            340                 345                 350         


Pro Thr Arg Pro Cys Pro Leu Pro Pro Gly Lys Arg Ser Ile Asn Lys 
        355                 360                 365             


Leu Asp Ser Pro Asp Pro Phe Lys Leu Asn Asp Pro Phe Gln Pro Phe 
    370                 375                 380                 


Pro Gly Asn Asp Ser Pro Lys Glu Lys Asp Pro Glu Ile Phe Cys Asp 
385                 390                 395                 400 


Pro Phe Thr Ser Ala Thr Thr Thr Thr Asn Lys Glu Ala Asp Pro Ser 
                405                 410                 415     


Asn Phe Ala Asn Phe Ser Ala Tyr Pro Ser Glu Glu Asp Met Ile Glu 
            420                 425                 430         


Trp Ala Lys Arg Glu Ser Glu Arg Glu Glu Glu Gln Arg Leu Ala Arg 
        435                 440                 445             


Leu Asn Gln Gln Glu Gln Glu Asp Leu Glu Leu Ala Ile Ala Leu Ser 
    450                 455                 460                 


Lys Ser Glu Ile Ser Glu Ala 
465                 470     


<210>  6329
<211>  4256
<212>  DNA
<213>  Homosapiens

<400>  6329
ggcctcgcct gcggccgctc cctccgcctc ctccccgccc cgagccccag tcagcccgtc     60

ttccttcccc tcccttgcat gatggaaaca ccatggctgc ggcggcccag ctctctctga    120

cacagttatc aagtgggaat cctgtatatg aaaaatacta tagacaggtt gatacaggca    180

atactggaag ggtgttggct tctgatgctg ctgctttcct gaaaaaatca gggcttccag    240

acttgatact tggaaagatt tgggatttag ccgacacaga tggcaaaggt atcctgaaca    300

aacaagaatt ctttgttgct ttgcgtcttg tggcatgtgc ccagaatgga ttggaagttt    360

cactaagtag tttgaacctg gctgttcctc caccaagatt tcatgatacc agtagtcctt    420

tgctaatcag tggaacctct gcagctgagc tcccatgggc tgtaaaacct gaagataagg    480

ccaaatatga tgcaatattt gatagtttaa gcccagtgaa tggatttctg tctggtgata    540

aagtgaaacc agtgttgctc aactctaagt tacctgtgga tatccttgga agagtttggg    600

agttgagtga tattgaccat gatggaatgc ttgacagaga tgagtttgca gttgccatgt    660

ttttggtata ctgtgcactg gagaaagaac ctgtgccaat gtccttgcct ccagccttgg    720

tgccaccatc taagagaaaa acgtgggttg tatcccctgc agaaaaagct aaatatgatg    780

aaatcttcct gaaaactgat aaagatatgg acggatttgt gtctggattg gaggtccgtg    840

aaatattctt gaaaacaggt ttaccttcta ccttactagc ccatatatgg tcattatgcg    900

acacaaagga ctgtgggaag ctttcaaagg atcagtttgc cttggctttt cacttaatca    960

gtcagaagtt aatcaagggc attgatcctc ctcacgttct tactcctgaa atgattccac   1020

catcagacag ggccagttta caaaagaaca tcataggatc aagtcctgtt gcagatttct   1080

ctgctattaa ggaactagat actcttaaca atgaaatagt tgacctacag agggaaaaga   1140

ataatgtgga acaggacctt aaggagaagg aagatactat taaacagagg acaagtgagg   1200

ttcaggatct tcaagatgaa gttcaaaggg agaatactaa tctgcaaaaa ctacaggccc   1260

agaaacagca ggtacaggaa ctccttgatg aactggatga gcagaaagcc cagctggagg   1320

agcaactcaa ggaagtcaga aagaaatgtg ctgaggaggc ccaactgatc tcttctctga   1380

aagctgaatt aactagtcag gaatcgcaga tctccactta cgaagaagaa ttggcaaaag   1440

ctagagaaga gctgagccgt ctacagcaag aaacagcaga attggaggag agtgtagagt   1500

cagggaaggc tcagttggaa cctcttcagc agcacctaca agattcacaa caggaaatta   1560

gttcaatgca aatgaaactg atggaaatga aagatttgga aaatcataat agtcagttaa   1620

attggtgcag tagcccacac agcattcttg taaacggagc tacagattat tgcagcctca   1680

gcaccagcag cagtgaaaca gccaacctta atgaacatgt tgaaggccag agcaacctag   1740

agtctgagcc catacaccag gaatctccag caagaagtag tcctgaacta ctgccttctg   1800

gtgtgactga tgaaaatgag gtgactacag ctgttactga aaaagtttgt tctgaactcg   1860

acaataatag acattcaaaa gaggaagatc catttaatgt agactcaagt tcgctgacag   1920

gtccagttgc agatacaaac ttggattttt tccagtctga tccttttgtt ggcagtgatc   1980

ctttcaagga tgatcctttt ggaaaaatcg atccatttgg tggtgatcct ttcaaaggtt   2040

cagatccatt tgcatcagac tgtttcttca ggcaatctac tgatcctttt gccacttcaa   2100

gcactgaccc tttcagtgca gccaacaata gcagtattac atcggtagaa acgttgaagc   2160

acaatgatcc ttttgctcct ggtggaacag ttgttgcagc aagcgattca gccacagacc   2220

cctttgcttc tgtttttggg aatgaatcat ttggaggtgg atttgctgac ttcagcacat   2280

tgtcaaaggt caacaatgaa gatccttttc gttcagccac atcgagctct gtcagcaacg   2340

tagtgattac aaaaaatgta tttgaggaaa catcggtcaa aagtgaagat gaacccccag   2400

cactgccacc aaagatcgga actccaacaa gaccctgccc tctaccacct gggaaaagat   2460

ccatcaacaa attggattct cctgatccct ttaaactgaa tgatccattt cagcctttcc   2520

caggcaacga tagccccaaa gaaaaagatc ctgaaatatt ttgtgatcca ttcacttctg   2580

ctactaccac taccaataaa gaggctgatc caagcaattt tgccaacttc agtgcttatc   2640

cctctgaaga agatatgatc gaatgggcca agagggaaag tgagagagag gaagagcaga   2700

ggcttgcccg actaaatcag caggaacaag aagacttaga actggctatt gcactcagca   2760

aatctgagat atcagaagca tgaagaattc tcttgttctt tggcaacaat atagtattct   2820

tcttcctgaa tactgaaact atttacaatg tgtatcaaaa ctacctgtga gcatgggaat   2880

acaaaaggtt tgagattcct gtaaatgtga caaaatttta ggattttttt tttttcttca   2940

ttacagattc gtcttttttt ttttttctta taaaagccgt aacccagtca gacaaattca   3000

ccttcactta ggcccctgtt ctggtataca tttactgtga gcttttgcct gcctgtgcta   3060

ttttacttgt aaagctagag cacccaagct tctgccttct ggaatataga gaaatagttt   3120

caccctgcac taccctgttc tgtagttatt ctgatgatag ccagtgaggt tcttaaagtt   3180

tgcagtattc tcccctgatt ggaatggttg agtgagggta agggaaagaa tatcttattt   3240

cttttatgat tggtgcaaat tggctaaagt gcatttttaa atttcctcta cttaatttgt   3300

ttttcagaga taaggaaaaa tattttgcac agatttactc cactatggaa aagggatgct   3360

gtaggttgaa ccattatagc ctcagattcg atcttttcct aactaaaaat attaaagcct   3420

catgtgtgaa ataaattttt aaaaagattt atctggattt agagaatttt agatcaacag   3480

atacctctca gtgtgtttgc taattaataa aaatcagttt cttacaaata aagtttgtaa   3540

gaaaatgttc attttaagtg atagatagtg gagaaaattt atcacctaaa atatacccat   3600

cagtataagg caagcaaaag tcttaacatg gcagccattc tgcctttgcc gtggccctgt   3660

cctgtttagt tcttagtggg ttaatttttg tacttttgca gaagaaactt cagcaagcta   3720

gaactggaag gtactttaat ttttcatata tatttgtttt ttttttttta atgaaggctc   3780

atttacttga aatgtaaaaa ctttcactga atacaaatag aaaaagtgat gtgttttata   3840

tcatattgct ttttgtccat ctttgtggtt tagtttattt actcacttca tgtttttcac   3900

ctataaaatt gtcaagctag caaaaaaact cttgtttttt taattgggag agaagagacc   3960

tgccagatta tcagacctct tcatgttaaa agaccatctc ctgtaaaact gacctagtgg   4020

acaagctgaa tttgaaatag actgtgaagt aagctgtaac ttgtcatttt aattttgttt   4080

aacacggtta ctgacttaga tgatgtatta aataccaaga taaagaaaaa tgcacctaaa   4140

atctaattag aattctctgg gtcaacaagt caaggtggta ttgatctgtg ttaatctgag   4200

taacttattg cctagcctat aaataaattc caaaatatcc aattcatttc ttcttg       4256


<210>  6330
<211>  896
<212>  PRT
<213>  Homosapiens

<400>  6330

Met Ala Ala Ala Ala Gln Leu Ser Leu Thr Gln Leu Ser Ser Gly Asn 
1               5                   10                  15      


Pro Val Tyr Glu Lys Tyr Tyr Arg Gln Val Asp Thr Gly Asn Thr Gly 
            20                  25                  30          


Arg Val Leu Ala Ser Asp Ala Ala Ala Phe Leu Lys Lys Ser Gly Leu 
        35                  40                  45              


Pro Asp Leu Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Thr Asp Gly 
    50                  55                  60                  


Lys Gly Ile Leu Asn Lys Gln Glu Phe Phe Val Ala Leu Arg Leu Val 
65                  70                  75                  80  


Ala Cys Ala Gln Asn Gly Leu Glu Val Ser Leu Ser Ser Leu Asn Leu 
                85                  90                  95      


Ala Val Pro Pro Pro Arg Phe His Asp Thr Ser Ser Pro Leu Leu Ile 
            100                 105                 110         


Ser Gly Thr Ser Ala Ala Glu Leu Pro Trp Ala Val Lys Pro Glu Asp 
        115                 120                 125             


Lys Ala Lys Tyr Asp Ala Ile Phe Asp Ser Leu Ser Pro Val Asn Gly 
    130                 135                 140                 


Phe Leu Ser Gly Asp Lys Val Lys Pro Val Leu Leu Asn Ser Lys Leu 
145                 150                 155                 160 


Pro Val Asp Ile Leu Gly Arg Val Trp Glu Leu Ser Asp Ile Asp His 
                165                 170                 175     


Asp Gly Met Leu Asp Arg Asp Glu Phe Ala Val Ala Met Phe Leu Val 
            180                 185                 190         


Tyr Cys Ala Leu Glu Lys Glu Pro Val Pro Met Ser Leu Pro Pro Ala 
        195                 200                 205             


Leu Val Pro Pro Ser Lys Arg Lys Thr Trp Val Val Ser Pro Ala Glu 
    210                 215                 220                 


Lys Ala Lys Tyr Asp Glu Ile Phe Leu Lys Thr Asp Lys Asp Met Asp 
225                 230                 235                 240 


Gly Phe Val Ser Gly Leu Glu Val Arg Glu Ile Phe Leu Lys Thr Gly 
                245                 250                 255     


Leu Pro Ser Thr Leu Leu Ala His Ile Trp Ser Leu Cys Asp Thr Lys 
            260                 265                 270         


Asp Cys Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala Phe His Leu 
        275                 280                 285             


Ile Ser Gln Lys Leu Ile Lys Gly Ile Asp Pro Pro His Val Leu Thr 
    290                 295                 300                 


Pro Glu Met Ile Pro Pro Ser Asp Arg Ala Ser Leu Gln Lys Asn Ile 
305                 310                 315                 320 


Ile Gly Ser Ser Pro Val Ala Asp Phe Ser Ala Ile Lys Glu Leu Asp 
                325                 330                 335     


Thr Leu Asn Asn Glu Ile Val Asp Leu Gln Arg Glu Lys Asn Asn Val 
            340                 345                 350         


Glu Gln Asp Leu Lys Glu Lys Glu Asp Thr Ile Lys Gln Arg Thr Ser 
        355                 360                 365             


Glu Val Gln Asp Leu Gln Asp Glu Val Gln Arg Glu Asn Thr Asn Leu 
    370                 375                 380                 


Gln Lys Leu Gln Ala Gln Lys Gln Gln Val Gln Glu Leu Leu Asp Glu 
385                 390                 395                 400 


Leu Asp Glu Gln Lys Ala Gln Leu Glu Glu Gln Leu Lys Glu Val Arg 
                405                 410                 415     


Lys Lys Cys Ala Glu Glu Ala Gln Leu Ile Ser Ser Leu Lys Ala Glu 
            420                 425                 430         


Leu Thr Ser Gln Glu Ser Gln Ile Ser Thr Tyr Glu Glu Glu Leu Ala 
        435                 440                 445             


Lys Ala Arg Glu Glu Leu Ser Arg Leu Gln Gln Glu Thr Ala Glu Leu 
    450                 455                 460                 


Glu Glu Ser Val Glu Ser Gly Lys Ala Gln Leu Glu Pro Leu Gln Gln 
465                 470                 475                 480 


His Leu Gln Asp Ser Gln Gln Glu Ile Ser Ser Met Gln Met Lys Leu 
                485                 490                 495     


Met Glu Met Lys Asp Leu Glu Asn His Asn Ser Gln Leu Asn Trp Cys 
            500                 505                 510         


Ser Ser Pro His Ser Ile Leu Val Asn Gly Ala Thr Asp Tyr Cys Ser 
        515                 520                 525             


Leu Ser Thr Ser Ser Ser Glu Thr Ala Asn Leu Asn Glu His Val Glu 
    530                 535                 540                 


Gly Gln Ser Asn Leu Glu Ser Glu Pro Ile His Gln Glu Ser Pro Ala 
545                 550                 555                 560 


Arg Ser Ser Pro Glu Leu Leu Pro Ser Gly Val Thr Asp Glu Asn Glu 
                565                 570                 575     


Val Thr Thr Ala Val Thr Glu Lys Val Cys Ser Glu Leu Asp Asn Asn 
            580                 585                 590         


Arg His Ser Lys Glu Glu Asp Pro Phe Asn Val Asp Ser Ser Ser Leu 
        595                 600                 605             


Thr Gly Pro Val Ala Asp Thr Asn Leu Asp Phe Phe Gln Ser Asp Pro 
    610                 615                 620                 


Phe Val Gly Ser Asp Pro Phe Lys Asp Asp Pro Phe Gly Lys Ile Asp 
625                 630                 635                 640 


Pro Phe Gly Gly Asp Pro Phe Lys Gly Ser Asp Pro Phe Ala Ser Asp 
                645                 650                 655     


Cys Phe Phe Arg Gln Ser Thr Asp Pro Phe Ala Thr Ser Ser Thr Asp 
            660                 665                 670         


Pro Phe Ser Ala Ala Asn Asn Ser Ser Ile Thr Ser Val Glu Thr Leu 
        675                 680                 685             


Lys His Asn Asp Pro Phe Ala Pro Gly Gly Thr Val Val Ala Ala Ser 
    690                 695                 700                 


Asp Ser Ala Thr Asp Pro Phe Ala Ser Val Phe Gly Asn Glu Ser Phe 
705                 710                 715                 720 


Gly Gly Gly Phe Ala Asp Phe Ser Thr Leu Ser Lys Val Asn Asn Glu 
                725                 730                 735     


Asp Pro Phe Arg Ser Ala Thr Ser Ser Ser Val Ser Asn Val Val Ile 
            740                 745                 750         


Thr Lys Asn Val Phe Glu Glu Thr Ser Val Lys Ser Glu Asp Glu Pro 
        755                 760                 765             


Pro Ala Leu Pro Pro Lys Ile Gly Thr Pro Thr Arg Pro Cys Pro Leu 
    770                 775                 780                 


Pro Pro Gly Lys Arg Ser Ile Asn Lys Leu Asp Ser Pro Asp Pro Phe 
785                 790                 795                 800 


Lys Leu Asn Asp Pro Phe Gln Pro Phe Pro Gly Asn Asp Ser Pro Lys 
                805                 810                 815     


Glu Lys Asp Pro Glu Ile Phe Cys Asp Pro Phe Thr Ser Ala Thr Thr 
            820                 825                 830         


Thr Thr Asn Lys Glu Ala Asp Pro Ser Asn Phe Ala Asn Phe Ser Ala 
        835                 840                 845             


Tyr Pro Ser Glu Glu Asp Met Ile Glu Trp Ala Lys Arg Glu Ser Glu 
    850                 855                 860                 


Arg Glu Glu Glu Gln Arg Leu Ala Arg Leu Asn Gln Gln Glu Gln Glu 
865                 870                 875                 880 


Asp Leu Glu Leu Ala Ile Ala Leu Ser Lys Ser Glu Ile Ser Glu Ala 
                885                 890                 895     


<210>  6331
<211>  723
<212>  DNA
<213>  Homosapiens

<400>  6331
tcctttttta atctatcctc ttttcaccac attttagtga gaaagcaatt ttttttttac     60

aaatggagct tatattgatt tttatttcat aaataattga aagagggtag aaaaatctgc    120

ccttcattta aaaattgaat gtttcactat gtatttaaaa agcgattcag gattaggagg    180

atggataacc ataccagctg tagctgatgt tctaaaatat tcttgcattg tttgctggtc    240

ttctagggaa aagaataatg tggaacagga ccttaaggag aaggaagata ctattaaaca    300

gaggacaagt gaggttcagg atcttcaaga tgaagttcaa agggagaata ctaatctgca    360

aaaactacag gcccagaaac agcaggtaca ggaactcctt gatgaactgg atgagcagaa    420

agcccagctg gaggagcaac tcaaggaagt cagaaagaaa tgtgctgagg aggcccaact    480

gatctcttct ctgaaagctg aattaactag tcaggaatcg cagatctcca cttacgaaga    540

agaattggca aaagctagag aagagctgag ccgtctacag caagaaacag cagaattgga    600

ggagagtgta gagtcaggga aggctcagtt ggaacctctt cagcagcacc tacaagattc    660

acaacaggaa attagttcag caagaagtag tcctgaacta ctgccttctg gtgtgactga    720

tga                                                                  723


<210>  6332
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  6332

Met Tyr Leu Lys Ser Asp Ser Gly Leu Gly Gly Trp Ile Thr Ile Pro 
1               5                   10                  15      


Ala Val Ala Asp Val Leu Lys Tyr Ser Cys Ile Val Cys Trp Ser Ser 
            20                  25                  30          


Arg Glu Lys Asn Asn Val Glu Gln Asp Leu Lys Glu Lys Glu Asp Thr 
        35                  40                  45              


Ile Lys Gln Arg Thr Ser Glu Val Gln Asp Leu Gln Asp Glu Val Gln 
    50                  55                  60                  


Arg Glu Asn Thr Asn Leu Gln Lys Leu Gln Ala Gln Lys Gln Gln Val 
65                  70                  75                  80  


Gln Glu Leu Leu Asp Glu Leu Asp Glu Gln Lys Ala Gln Leu Glu Glu 
                85                  90                  95      


Gln Leu Lys Glu Val Arg Lys Lys Cys Ala Glu Glu Ala Gln Leu Ile 
            100                 105                 110         


Ser Ser Leu Lys Ala Glu Leu Thr Ser Gln Glu Ser Gln Ile Ser Thr 
        115                 120                 125             


Tyr Glu Glu Glu Leu Ala Lys Ala Arg Glu Glu Leu Ser Arg Leu Gln 
    130                 135                 140                 


Gln Glu Thr Ala Glu Leu Glu Glu Ser Val Glu Ser Gly Lys Ala Gln 
145                 150                 155                 160 


Leu Glu Pro Leu Gln Gln His Leu Gln Asp Ser Gln Gln Glu Ile Ser 
                165                 170                 175     


Ser Ala Arg Ser Ser Pro Glu Leu Leu Pro Ser Gly Val Thr 
            180                 185                 190 


<210>  6333
<211>  650
<212>  DNA
<213>  Homosapiens

<400>  6333
gggcaacata gcaagaccct gtctctacaa aaaagaaaga aagaaagaaa gaaaattgga     60

tttttttggt aagctaaatg gaatttatag ctaccaggta tggagagtta cttatagaag    120

tttttgtcct tatttgtaat aaaataaata ttttattatc tgctttgtga gttatggggg    180

gggccttttt gtgaattttt tgattcctta tgatgtatga catgagtccc ttaagttgtg    240

gaaaaggctg aaagtgatgc cacccagaag gataaaggtt actgaatatg catttttgct    300

ctttgctata taactgtacc tcagttatgg aatactgtgt tgtttcatgc tttctttcac    360

ctatgcagac tgcttttttt ttttctgcct tcttcatttt ataacctatt caattgccta    420

ccaacacaaa ttttagatat gacagaaatt tctgaagcaa attaaaagtt tgaagtctat    480

gttagtagat gcttgaagtt gcatgaggta tagtttttaa tttagtagat ttgtctgaag    540

ttcattcact agatcataga tacgtttgtc tatttatgtc agataccagt attattcatt    600

gaaatgggaa tttatcactg ctatcttatc tattaaccca aaattttaac               650


<210>  6334
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  6334

Met His Phe Cys Ser Leu Leu Tyr Asn Cys Thr Ser Val Met Glu Tyr 
1               5                   10                  15      


Cys Val Val Ser Cys Phe Leu Ser Pro Met Gln Thr Ala Phe Phe Phe 
            20                  25                  30          


Ser Ala Phe Phe Ile Leu 
        35              


<210>  6335
<211>  402
<212>  DNA
<213>  Homosapiens

<400>  6335
acttgttaac cattttgtca catttgcttt ctccctgtat ccatattctt cagaattttt     60

tcctagtttt aaactctagc ttgtgtgatt ttaatactgc ttctcctgtt ccctcttttt    120

ttgaattacc tgatatttct tatgtttgtt gtgtatgtct cttgaaaatg gcagatttct    180

gtattttaat gctttaccta attggatagt ttttaagata atagcactta tattgatttg    240

attttccctt ctttaccgat ttattttaca tttttatttt ctctgtttct tactgttgct    300

tattatcaac ttgtgattca ttcccatccc caagatagga taatattcca gaatctggaa    360

aaaaaaaaaa aaaaaaaaaa aaagataata ttccaaaatc cg                       402


<210>  6336
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  6336

Asp Asn Ser Thr Tyr Ile Asp Leu Ile Phe Pro Ser Leu Pro Ile Tyr 
1               5                   10                  15      


Phe Thr Phe Leu Phe Ser Leu Phe Leu Thr Val Ala Tyr Tyr Gln Leu 
            20                  25                  30          


Val Ile His Ser His Pro Gln Asp Arg Ile Ile Phe Gln Asn Leu Glu 
        35                  40                  45              


Lys Lys Lys Lys Lys Lys Lys Lys Ile Ile Phe Gln Asn 
    50                  55                  60      


<210>  6337
<211>  1828
<212>  DNA
<213>  Homosapiens

<400>  6337
ccgcctcctc cccgccccga gccccagtca gcccgtcttc cttcccctcc cttgcatgat     60

ggaaacacca tggctgcggc ggcccagctc tctctgacac agttatcaag tgggaatcct    120

gtatatgaaa aatactatag acaggttgat acaggcaata ctggaagggt gttggcttct    180

gatgctgctg ctttcctgaa aaaatcaggg cttccagact tgatacttgg aaagatttgg    240

gatttagccg acacagatgg caaaggtatc ctgaacaaac aagaattctt tgttgctttg    300

cgtcttgtgg catgtgccca gaatggattg gaagtttcac taagtagttt gaacctggct    360

gttcctccac caagatttca tgataccagt agtcctttgc taatcagtgg aacctctgca    420

gctgagctcc catgggctgt aaaacctgaa gataaggcca aatatgatgc aatatttgat    480

agtttaagcc cagtgaatgg atttctgtct ggtgataaag tgaaaccagt gttgctcaac    540

tctaagttac ctgtggatat ccttggaaga gtttgggagt tgagtgatat tgaccatgat    600

ggaatgcttg acagagatga gtttgcagtt acggagtctc actctgtcac tcaggctgga    660

gtgcagtggc gggatctcag ctcactgcag cctcggcctc ctggattcaa gttattcttc    720

cacctcagcc tcctgaggag ctgggattac aggcatgcac caccaccccc ggctaatttt    780

tatattttta gtagagacag cgtttcgccg tgtttgccag actggtctcg agctcctgat    840

aataggtgat ccactcgcct cggcctccca aagtgccggg attacaggca tgagccacct    900

cttcaggccc aagacaaaaa tatagttaga gtagatgggg aatagtagtg tcatcatttg    960

ataaacagta gtgcatgcta aggtaaatga ataaacacaa tttatcttat atgcctggag   1020

cctattccca ggtaactggc cttttttttt tttaataaaa agctttatta aaaataattt   1080

ttgaataata aatacatttg taggaaatta ctaccttgaa ttttgtttta aatagtagac   1140

acccctttat cttctcctag atttacttgt taaccatttt gtcacatttg ctttctccct   1200

gtatccatat tcttcagaat tttttcctag ttttaaactc tagcttgtgt gattttaata   1260

ctgcttctcc tgttccctct ttttttgaat tacctgatat ttcttatgtt tgttgtgtat   1320

gtctcttgaa aatggcagat ttctgtattt taatgcttta cctaattgga tagtttttaa   1380

gataatagca cttatattga tttgattttc ccttctttac cgatttattt tacattttta   1440

ttttctctgt ttcttactgt tgcttattat caacttgtga ttcattccct taccccgcct   1500

cccagttaat gtggaaattt tgttataatg tcttgtttca ttaatatagt taatacaggt   1560

tgagcatccc taatctgaaa atccaaaact tgaaatgctt caaaatctga aacttttgag   1620

tactgacatg acccacaaag tggaaaattc cactcctggt ctcatgtgat aagttacagt   1680

caaaactttt gtttcatgca caaaattatt aaaaagattg tataaaatta tcttagatta   1740

tgtgtataaa gtttatatga aacataaatg aatttcatgt ttagacttgg gtcccatccc   1800

caagatagga taatattcca gaatctgg                                      1828


<210>  6338
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  6338

Met Ala Ala Ala Ala Gln Leu Ser Leu Thr Gln Leu Ser Ser Gly Asn 
1               5                   10                  15      


Pro Val Tyr Glu Lys Tyr Tyr Arg Gln Val Asp Thr Gly Asn Thr Gly 
            20                  25                  30          


Arg Val Leu Ala Ser Asp Ala Ala Ala Phe Leu Lys Lys Ser Gly Leu 
        35                  40                  45              


Pro Asp Leu Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Thr Asp Gly 
    50                  55                  60                  


Lys Gly Ile Leu Asn Lys Gln Glu Phe Phe Val Ala Leu Arg Leu Val 
65                  70                  75                  80  


Ala Cys Ala Gln Asn Gly Leu Glu Val Ser Leu Ser Ser Leu Asn Leu 
                85                  90                  95      


Ala Val Pro Pro Pro Arg Phe His Asp Thr Ser Ser Pro Leu Leu Ile 
            100                 105                 110         


Ser Gly Thr Ser Ala Ala Glu Leu Pro Trp Ala Val Lys Pro Glu Asp 
        115                 120                 125             


Lys Ala Lys Tyr Asp Ala Ile Phe Asp Ser Leu Ser Pro Val Asn Gly 
    130                 135                 140                 


Phe Leu Ser Gly Asp Lys Val Lys Pro Val Leu Leu Asn Ser Lys Leu 
145                 150                 155                 160 


Pro Val Asp Ile Leu Gly Arg Val Trp Glu Leu Ser Asp Ile Asp His 
                165                 170                 175     


Asp Gly Met Leu Asp Arg Asp Glu Phe Ala Val Thr Glu Ser His Ser 
            180                 185                 190         


Val Thr Gln Ala Gly Val Gln Trp Arg Asp Leu Ser Ser Leu Gln Pro 
        195                 200                 205             


Arg Pro Pro Gly Phe Lys Leu Phe Phe His Leu Ser Leu Leu Arg Ser 
    210                 215                 220                 


Trp Asp Tyr Arg His Ala Pro Pro Pro Pro Ala Asn Phe Tyr Ile Phe 
225                 230                 235                 240 


Ser Arg Asp Ser Val Ser Pro Cys Leu Pro Asp Trp Ser Arg Ala Pro 
                245                 250                 255     


Asp Asn Arg 
            


<210>  6339
<211>  1925
<212>  DNA
<213>  Homosapiens

<400>  6339
ccgcctcctc cccgccccga gccccagtca gcccgtcttc cttcccctcc cttgcatgat     60

ggaaacacca tggctgcggc ggcccagctc tctctgacac agttatcaag tgggaatcct    120

gtatatgaaa aatactatag acaggttgat acaggcaata ctggaagggt gttggcttct    180

gatgctgctg ctttcctgaa aaaatcaggg cttccagact tgatacttgg aaagatttgg    240

gatttagccg acacagatgg caaaggtatc ctgaacaaac aagaattctt tgttgctttg    300

cgtcttgtgg catgtgccca gaatggattg gaagtttcac taagtagttt gaacctggct    360

gttcctccac caagatttca tgataccagt agtcctttgc taatcagtgg aacctctgca    420

gctgagctcc catgggctgt aaaacctgaa gataaggcca aatatgatgc aatatttgat    480

agtttaagcc cagtgaatgg atttctgtct ggtgataaag tgaaaccagt gttgctcaac    540

tctaagttac ctgtggatat ccttggaaga gtttgggagt tgagtgatat tgaccatgat    600

ggaatgcttg acagagatga gtttgcagtt gtaagtaatc taatgttctt aacatcttca    660

ttatcttaat gattttctca tgtgcaaatt tcctctttta gttcatcctt agaggaaaac    720

tatattctca tcagattatt gggtgaactt tttttttttt tctttttgag acagagtctc    780

actctgtcac ccaggctgga gtgcagtggc acaatcttgg ctcaccacaa cctctacctc    840

ccaggttcaa gtaattctcg tgcctcagcc tcccaagtat ctgggattgc aggcacatgc    900

caccacgccc agctaatttt ggtatctttt gaagagatgg ggttttgccg tgttggctag    960

gctggtcttg aactcctgac ctcaagtgat ctgcccacct cagcctccca aagtgctggg   1020

attacaggca tgaaccactg tgcccggctg gttgaacatt cttatataga atttatattt   1080

attttctaaa caaatggata acagaaaatg tgtgttctgc catcttcatt ttatttggct   1140

ttaaggtaca taggaacgta tactttgtat aattactgta aagatagtat cttttgtatc   1200

acaacctgac caggtatctt agtacctgct tctaatatgg aataattttg cttcaaatgt   1260

atctcccaaa tttcacattt ccttttattt catttaaagg aaacatgaat aacacttgag   1320

tttcacttca tttatgaagg cagaaaagtt ttgacatttt atctgaagac atgtcatctt   1380

agtaattgaa tagttaattc caaatatggt tgtattcacc tcttccttaa aggtttgata   1440

aaactttgct gtgaattcat cagtggtaaa tttctaattt cccttttact ctcagatttt   1500

ctctttttat tttggtaagg aattactaat ttcttttact ttcaaacttg ttgctacaaa   1560

tttgtgatac tctctttcgt ggttgttctc tttactcact ccaagtcttg ggagtactcc   1620

cacttgtatt tttacttaat ctgattttgt ctagtttatt gatctgttag aagaaccatc   1680

ttttgaattt acttatcctt tctattatat tttgactttt aatttaatga tgtttaacat   1740

ttaattccct gttacatttt cttattcttt ttattttaaa tttctcggag atgagtatta   1800

tgtttcttca gttctcttta tctttaatat tgaaatcatt taaaggatat attcaccctt   1860

gaatacaggt ttagtgggat tccatagata ttggtacaaa gttttctcct ttatacagct   1920

tttta                                                               1925


<210>  6340
<211>  199
<212>  PRT
<213>  Homosapiens

<400>  6340

Met Ala Ala Ala Ala Gln Leu Ser Leu Thr Gln Leu Ser Ser Gly Asn 
1               5                   10                  15      


Pro Val Tyr Glu Lys Tyr Tyr Arg Gln Val Asp Thr Gly Asn Thr Gly 
            20                  25                  30          


Arg Val Leu Ala Ser Asp Ala Ala Ala Phe Leu Lys Lys Ser Gly Leu 
        35                  40                  45              


Pro Asp Leu Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Thr Asp Gly 
    50                  55                  60                  


Lys Gly Ile Leu Asn Lys Gln Glu Phe Phe Val Ala Leu Arg Leu Val 
65                  70                  75                  80  


Ala Cys Ala Gln Asn Gly Leu Glu Val Ser Leu Ser Ser Leu Asn Leu 
                85                  90                  95      


Ala Val Pro Pro Pro Arg Phe His Asp Thr Ser Ser Pro Leu Leu Ile 
            100                 105                 110         


Ser Gly Thr Ser Ala Ala Glu Leu Pro Trp Ala Val Lys Pro Glu Asp 
        115                 120                 125             


Lys Ala Lys Tyr Asp Ala Ile Phe Asp Ser Leu Ser Pro Val Asn Gly 
    130                 135                 140                 


Phe Leu Ser Gly Asp Lys Val Lys Pro Val Leu Leu Asn Ser Lys Leu 
145                 150                 155                 160 


Pro Val Asp Ile Leu Gly Arg Val Trp Glu Leu Ser Asp Ile Asp His 
                165                 170                 175     


Asp Gly Met Leu Asp Arg Asp Glu Phe Ala Val Val Ser Asn Leu Met 
            180                 185                 190         


Phe Leu Thr Ser Ser Leu Ser 
        195                 


<210>  6341
<211>  644
<212>  DNA
<213>  Homosapiens

<400>  6341
gtgctgtaca ctcttgacct cctatttgct tgagttaatt tctagagacc atcagtattt     60

tatgtctgcc acttactctg tggctgtatc atggtgtctt gttgtaagga atagttttat    120

ctctgaaatc ataaattctt ctctctaact tgtacttcct gtctttatag agctcttttc    180

cagaaactag caagactaat tctttgactg gttttactaa gacctttaaa tctgacttct    240

tggctgggca tggtggctca cacctgcttc agcctcccaa agtgttgaga ttacagcgtg    300

agccaccagc acccggctgc cctttcttta attacctgct tcagcagatt acatagggtc    360

aaatcctggc tgcaccactt cttagctgtg tgaccttggg caagtcatta gaaagccatg    420

tctcagtttt ctaatcttta aaagggacat aattcccagc ttatagaatt gtagtgattg    480

aatgtgataa tgaatgttaa gtcctgctta ttaccatgat tgctacatac tctttgaatg    540

ctagctgcta tgatgatgac aaccaccata ccaccatatt attactacta ctggatcaat    600

gttatataga ttttagatgc tcaataaata tttatttaaa tgcc                     644


<210>  6342
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  6342

Met Ile Ala Thr Tyr Ser Leu Asn Ala Ser Cys Tyr Asp Asp Asp Asn 
1               5                   10                  15      


His His Thr Thr Ile Leu Leu Leu Leu Leu Asp Gln Cys Tyr Ile Asp 
            20                  25                  30          


Phe Arg Cys Ser Ile Asn Ile Tyr Leu Asn 
        35                  40          


<210>  6343
<211>  259
<212>  DNA
<213>  Homosapiens

<400>  6343
ggcaatactg gaagggtgtt ggcttctgat gctgctgctt tcctgaaaaa atcagggctt     60

ccagacttga tacttggaaa gatttgggat ttagccgaca cagatggcaa aggtatcctg    120

aacaaacaag aattctttgt tgctttgcgt cttgtggcat gtgcccagaa tggattggaa    180

gtttcactaa gtagtttgaa cctggctgtt cctccaccaa gatttcatga taccagtagt    240

cctttgctaa tcagtggaa                                                 259


<210>  6344
<211>  85
<212>  PRT
<213>  Homosapiens

<400>  6344

Gly Asn Thr Gly Arg Val Leu Ala Ser Asp Ala Ala Ala Phe Leu Lys 
1               5                   10                  15      


Lys Ser Gly Leu Pro Asp Leu Ile Leu Gly Lys Ile Trp Asp Leu Ala 
            20                  25                  30          


Asp Thr Asp Gly Lys Gly Ile Leu Asn Lys Gln Glu Phe Phe Val Ala 
        35                  40                  45              


Leu Arg Leu Val Ala Cys Ala Gln Asn Gly Leu Glu Val Ser Leu Ser 
    50                  55                  60                  


Ser Leu Asn Leu Ala Val Pro Pro Pro Arg Phe His Asp Thr Ser Ser 
65                  70                  75                  80  


Pro Leu Leu Ile Ser 
                85  


<210>  6345
<211>  970
<212>  DNA
<213>  Homosapiens

<400>  6345
gatggaaaca ccatggctgc ggcggcccag ctctctctga cacaggaaga atttttaact     60

ttgaccatag agcataggaa ggggactcaa ggatagactt caaaagatct gtgatctact    120

ccaaaacaat ggagtcttcc tctgtcaccc agactggagt acagtgacgt gatctcagcc    180

cactgcaact tccatctccc aggttcaagc agttctcctg cctcagtatc ccaagtagct    240

gggattacag acagggtctt gctctgttgc ccaggctgga gtgcagtggt acaatcacag    300

ttcattgcaa cctcgacctc cagggctcaa gtgatcctcc cacctcagcc tccccagtag    360

ctgggactac aagtgcacgc caccttgccc agctaattgt ttttatattt tttgtagaga    420

tggggtttca ccatgttgcc caggctggtc ttgaactcct gggcaacatg ctcgctttcg    480

cctcccagag tgctgggatt acaggctgac ataagccacc ttgcctggcc tgaagtttat    540

aatttttata aagtctaatt tatatatatt tttcttttgt tgcttgtgct tttggtgaca    600

tagctgagtc ttttggcaaa tctaaggtca tgaagattta tccctgtgtt ttcttttaag    660

agttttatag ttttagctat tatatctagg tccttgatct atttcaagtt gatttttata    720

tatggtgtga ggtaaaggtc caacttcatt tttttgctag tggatatctt ttgcttgtga    780

catggtattc cagcatcatt tgttgaaaag gctattcttt ccacattgaa tgatcttggc    840

actcttgtca ataatcagtt aaccatagat gtatgattta gttctgactt aattctgttc    900

cattgatcta tatgtcctgt gcagtacaac actgtcttga gtattgttgt tttgtaatac    960

attttgaaat                                                           970


<210>  6346
<211>  41
<212>  PRT
<213>  Homosapiens

<400>  6346

Met Leu Pro Arg Leu Val Leu Asn Ser Trp Ala Thr Cys Ser Leu Ser 
1               5                   10                  15      


Pro Pro Arg Val Leu Gly Leu Gln Ala Asp Ile Ser His Leu Ala Trp 
            20                  25                  30          


Pro Glu Val Tyr Asn Phe Tyr Lys Val 
        35                  40      


<210>  6347
<211>  515
<212>  DNA
<213>  Homosapiens

<400>  6347
ggcaaggaag acgggatggg ccccaatcgg gaagcacgcg ccaccagctc tggagagaac     60

cgtctgagga gacgcggggg agagtttggg tcacaggagc aggaaggaac tggcaggtgt    120

ctgtcacctt atcatcccgg acaccatgtt tacattgtaa ttggcttctt tacagagagg    180

gagggaccag gttcccagtg tgagtgatgt ttagaggttt tctgagaagc acaaggactg    240

gactttgaca ggaagcaacg aggcaagagg gaagctcgag aacaggtttt gctgaggatt    300

ccccccaaga aaagtgctcc ccgggaggcc gttcctggca ccaagactgg cggagccacc    360

acacccgtta aagggatcca cctggacagc gatcaggcgt gagccccccg aggggaagtt    420

gaagtggaag cagacaagca cctccaagga tcacgtagga ccagcagaag cagcgtaaag    480

tattggaact ttgaatctga catcagaaag acctg                               515


<210>  6348
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  6348

Met Gly Pro Asn Arg Glu Ala Arg Ala Thr Ser Ser Gly Glu Asn Arg 
1               5                   10                  15      


Leu Arg Arg Arg Gly Gly Glu Phe Gly Ser Gln Glu Gln Glu Gly Thr 
            20                  25                  30          


Gly Arg Cys Leu Ser Pro Tyr His Pro Gly His His Val Tyr Ile Val 
        35                  40                  45              


Ile Gly Phe Phe Thr Glu Arg Glu Gly Pro Gly Ser Gln Cys Glu 
    50                  55                  60              


<210>  6349
<211>  680
<212>  DNA
<213>  Homosapiens

<400>  6349
ggcaaggaag acgggatggg ccccaatcgg gaagcacgcg ccaccagctc tggagagaac     60

cgtctgagga gacgcggggg agagtttggg tcacaggagc aggaaggaac tggcaggtgt    120

ctgtcacctt atcatcccgg acaccatgtt tacattgtaa ttggcttctt tacagagagg    180

gagggaccag gttcccagtg tgagtgatgt ttagaggttt tctgagaagc acaaggactg    240

gactttgaca ggaagcaacg aggcaagagg gaagctcgag aacaggtttt gctgaggatt    300

ccccccaaga aaagtgctcc ccgggaggcc gttcctggca ccaagactgg cggagccacc    360

acacccgtta aagggatcca cctggacagc gatcaggcca cctccaagga tcacgtagga    420

ccagcagaag cagcgtaaag tattggaact ttgaatctga catcagaaag acctgcactc    480

agccgggcac ggtggctcac gattgtaatc ccaggccgag gcggtggatc acttgagatt    540

cactgattct aggtaaatca gaggaacaag caacatgaac agaaaaaatg tagaaaatgc    600

aattatgctg aagtacaatt gttgtttcag aagtccagca tctggtgtac ttaacaatag    660

agaatatatt aaatttttcc                                                680


<210>  6350
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  6350

Met Gly Pro Asn Arg Glu Ala Arg Ala Thr Ser Ser Gly Glu Asn Arg 
1               5                   10                  15      


Leu Arg Arg Arg Gly Gly Glu Phe Gly Ser Gln Glu Gln Glu Gly Thr 
            20                  25                  30          


Gly Arg Cys Leu Ser Pro Tyr His Pro Gly His His Val Tyr Ile Val 
        35                  40                  45              


Ile Gly Phe Phe Thr Glu Arg Glu Gly Pro Gly Ser Gln Cys Glu 
    50                  55                  60              


<210>  6351
<211>  3280
<212>  DNA
<213>  Homosapiens

<400>  6351
atgattataa gcttcctgag gcctccctag aagctgagca gatggcagaa ccatgcttcc     60

tgtaaatcct gcagaatcaa gaaggaactg agtctctaag atggaggata tacaactgac    120

aagtagtaaa gtcaagatac acagccagac agtgtctcag tctggcatcc aactcaggct    180

ggagtgcagt gacatgatct tggctcactg cagtcttgac ctcctgggct caagcaatcc    240

tcctgcctca gcttcctgag tagattataa ataatcttaa tagcagtatt cacgtttgca    300

ttctcgcatc cgtggcatgg agtcctacac acaataggcg ccctaagaaa gcgtgtttga    360

cttgatcgct ggagcatctg ccggcaccgc ccaggacccg cccaggaccc gccccgcccc    420

ctgcggcccc gccccccgca tgctgaatgc catataggcg agtgacgtca ggccgtttgt    480

tgtcattggc ggctcccaag atggcgtcca tcatggaagg gccgctgagc aaatggacta    540

acgtgatgaa gggctggcag taccgttggt tcgtgctgga ctacaatgca ggactgctct    600

cctactacac gtccaaggac aaaatgatga gaggctctcg cagaggatgt gttagactca    660

gaggagctgt gattggtata gacgatgagg acgacagcac cttcacaata actgttgatc    720

agaaaacctt ccatttccag gcccgtgatg ctgatgagcg agagaagtgg atccatgcct    780

tagaagaaac aattcttcga catactctcc agcttcaagg tttggattca ggatttgttc    840

ctagtgtcca agattttgat aagaaactta cagaagctga tgcttaccta caaatcttga    900

ttgaacaatt aaagcttttt gatgacaagc ttcaaaactg caaagaagat gaacagagaa    960

agaaaattga aactctcaaa gagacaacaa atagcatggt agaatcaatt aaacactgca   1020

ttgtgttgct gcagattgcc aaaagtacta ttaatcccgt agatgcaata tatcaaccta   1080

gtcctttgga acctgtgatc agcacaatgc cttcccagac tgtgttacct ccagaacctg   1140

ttcagttgtg taagtcagag cagcgtccat cttccctacc agttggacct gtgttggcta   1200

ccttgggaca tcatcagact cctacaccaa atagtacagg cagtggccat tcaccaccga   1260

gtagcagtct cacttctcca agccacgtga acttgtctcc aaatacagtc ccagagttct   1320

cttactccag cagtgaagat gaattttatg atgctgatga attccatcaa agtggctcat   1380

ccccaaagcg cttaatagat tcttctggat ctgcctcagt cctgacacac agcagctcgg   1440

gaaatagtct aaaacgccca gataccacag aatcacttaa ttcttccttg tccaatggaa   1500

caagtgatgc tgacctgttt gattcacatg atgacagaga tgatgatgcg gaggcagggt   1560

ctgtggagga gcacaagagc gttatcatgc atctcttgtc gcaggttaga cttggaatgg   1620

atcttactaa ggtagttctt ccaacgttta ttcttgaaag aagatctctt ttagaaatgt   1680

atgcagactt ttttgcacat ccggacctgt ttgtgagcat tagtgaccag aaggatccca   1740

aggatcgaat ggttcaggtt gtgaaatggt acctctcagc ctttcatgcg ggaaggaaag   1800

gatcagttgc caaaaagcca tacaatccca ttttgggcga gatttttcag tgtcattgga   1860

cattaccaaa tgatactgaa gagaacacag aactagtttc agaaggacca gttccctggg   1920

tttccaaaaa cagtgtaaca tttgtggctg agcaggtttc ccatcatcca cccatttcag   1980

ccttttatgc tgagtgtttt aacaagaaga tacaattcaa tgctcatatc tggaccaaat   2040

caaaattcct tgggatgtca attggggtgc acaacatagg gcagggctgt gtctcatgtc   2100

tagactatga tgaacattac attctcacat tccccaatgg ctatggaagg tctatcctca   2160

cagtgccctg ggtggaatta ggaggagaat gcaatattaa ttgttccaaa acaggctata   2220

gtgcaaatat catcttccac actaaaccct tctatggggg caagaagcac agaattactg   2280

ccgagatttt ttctccaaat gacaagaagt ctttttgctc aattgaaggg gaatggaatg   2340

gtgtgatgta tgcaaaatat gcaacagggg aaaatacagt ctttgtagat accaagaagt   2400

tgcctataat caagaagaaa gtgaggaagt tggaagatca gaacgagtat gaatcccgca   2460

gcctttggaa ggatgtcact ttcaacttaa aaatcagaga cattgatgca gcaactgaag   2520

caaagcacag gcttgaagaa agacaaagag cagaagcccg agaaaggaag gagaaggaaa   2580

ttcagtggga gacaaggtta tttcatgaag atggagaatg ctgggtttat gatgaaccat   2640

tactgaaacg tcttggtgct gccaagcatt aggttggaag atgcaaagtt tatacctgat   2700

gatcagggca gtaggcataa ttcagcaaca aacaatcttc ctttgggaga aacctgttca   2760

ttccaatctt ctaattacag tggttcctat ctcagggata ctggactttc tgacgcagat   2820

gaacaattaa ggggaaaagc ttcccttttc cctctgtggc agttacgatt ttgacttcag   2880

tcctgagaaa aacttcaggt tttgaaaatc agatgatgtc ttctcctttt ccaaacacca   2940

cacgttgaaa gcatttataa atccaagtct gaaactctgc gctctagtac tgctgttaag   3000

atacacaact tgtttcttag ttcatataat ctcgggatac acacacacac acacatatat   3060

atacacacac atacgtatac acacacatac atatatataa atatacctga tgccagattt   3120

ttttcataaa tattctgcct actgtaaata tgggttcctc tgagttgttt tagaaaatta   3180

gcgcaatgta ttaaaatcaa gtgttaggaa atttcatggt cttacctaca ataactttta   3240

ttttggaatt gaactattat taaattgtat ctaatcctgg                         3280


<210>  6352
<211>  741
<212>  PRT
<213>  Homosapiens

<400>  6352

Met Pro Tyr Arg Arg Val Thr Ser Gly Arg Leu Leu Ser Leu Ala Ala 
1               5                   10                  15      


Pro Lys Met Ala Ser Ile Met Glu Gly Pro Leu Ser Lys Trp Thr Asn 
            20                  25                  30          


Val Met Lys Gly Trp Gln Tyr Arg Trp Phe Val Leu Asp Tyr Asn Ala 
        35                  40                  45              


Gly Leu Leu Ser Tyr Tyr Thr Ser Lys Asp Lys Met Met Arg Gly Ser 
    50                  55                  60                  


Arg Arg Gly Cys Val Arg Leu Arg Gly Ala Val Ile Gly Ile Asp Asp 
65                  70                  75                  80  


Glu Asp Asp Ser Thr Phe Thr Ile Thr Val Asp Gln Lys Thr Phe His 
                85                  90                  95      


Phe Gln Ala Arg Asp Ala Asp Glu Arg Glu Lys Trp Ile His Ala Leu 
            100                 105                 110         


Glu Glu Thr Ile Leu Arg His Thr Leu Gln Leu Gln Gly Leu Asp Ser 
        115                 120                 125             


Gly Phe Val Pro Ser Val Gln Asp Phe Asp Lys Lys Leu Thr Glu Ala 
    130                 135                 140                 


Asp Ala Tyr Leu Gln Ile Leu Ile Glu Gln Leu Lys Leu Phe Asp Asp 
145                 150                 155                 160 


Lys Leu Gln Asn Cys Lys Glu Asp Glu Gln Arg Lys Lys Ile Glu Thr 
                165                 170                 175     


Leu Lys Glu Thr Thr Asn Ser Met Val Glu Ser Ile Lys His Cys Ile 
            180                 185                 190         


Val Leu Leu Gln Ile Ala Lys Ser Thr Ile Asn Pro Val Asp Ala Ile 
        195                 200                 205             


Tyr Gln Pro Ser Pro Leu Glu Pro Val Ile Ser Thr Met Pro Ser Gln 
    210                 215                 220                 


Thr Val Leu Pro Pro Glu Pro Val Gln Leu Cys Lys Ser Glu Gln Arg 
225                 230                 235                 240 


Pro Ser Ser Leu Pro Val Gly Pro Val Leu Ala Thr Leu Gly His His 
                245                 250                 255     


Gln Thr Pro Thr Pro Asn Ser Thr Gly Ser Gly His Ser Pro Pro Ser 
            260                 265                 270         


Ser Ser Leu Thr Ser Pro Ser His Val Asn Leu Ser Pro Asn Thr Val 
        275                 280                 285             


Pro Glu Phe Ser Tyr Ser Ser Ser Glu Asp Glu Phe Tyr Asp Ala Asp 
    290                 295                 300                 


Glu Phe His Gln Ser Gly Ser Ser Pro Lys Arg Leu Ile Asp Ser Ser 
305                 310                 315                 320 


Gly Ser Ala Ser Val Leu Thr His Ser Ser Ser Gly Asn Ser Leu Lys 
                325                 330                 335     


Arg Pro Asp Thr Thr Glu Ser Leu Asn Ser Ser Leu Ser Asn Gly Thr 
            340                 345                 350         


Ser Asp Ala Asp Leu Phe Asp Ser His Asp Asp Arg Asp Asp Asp Ala 
        355                 360                 365             


Glu Ala Gly Ser Val Glu Glu His Lys Ser Val Ile Met His Leu Leu 
    370                 375                 380                 


Ser Gln Val Arg Leu Gly Met Asp Leu Thr Lys Val Val Leu Pro Thr 
385                 390                 395                 400 


Phe Ile Leu Glu Arg Arg Ser Leu Leu Glu Met Tyr Ala Asp Phe Phe 
                405                 410                 415     


Ala His Pro Asp Leu Phe Val Ser Ile Ser Asp Gln Lys Asp Pro Lys 
            420                 425                 430         


Asp Arg Met Val Gln Val Val Lys Trp Tyr Leu Ser Ala Phe His Ala 
        435                 440                 445             


Gly Arg Lys Gly Ser Val Ala Lys Lys Pro Tyr Asn Pro Ile Leu Gly 
    450                 455                 460                 


Glu Ile Phe Gln Cys His Trp Thr Leu Pro Asn Asp Thr Glu Glu Asn 
465                 470                 475                 480 


Thr Glu Leu Val Ser Glu Gly Pro Val Pro Trp Val Ser Lys Asn Ser 
                485                 490                 495     


Val Thr Phe Val Ala Glu Gln Val Ser His His Pro Pro Ile Ser Ala 
            500                 505                 510         


Phe Tyr Ala Glu Cys Phe Asn Lys Lys Ile Gln Phe Asn Ala His Ile 
        515                 520                 525             


Trp Thr Lys Ser Lys Phe Leu Gly Met Ser Ile Gly Val His Asn Ile 
    530                 535                 540                 


Gly Gln Gly Cys Val Ser Cys Leu Asp Tyr Asp Glu His Tyr Ile Leu 
545                 550                 555                 560 


Thr Phe Pro Asn Gly Tyr Gly Arg Ser Ile Leu Thr Val Pro Trp Val 
                565                 570                 575     


Glu Leu Gly Gly Glu Cys Asn Ile Asn Cys Ser Lys Thr Gly Tyr Ser 
            580                 585                 590         


Ala Asn Ile Ile Phe His Thr Lys Pro Phe Tyr Gly Gly Lys Lys His 
        595                 600                 605             


Arg Ile Thr Ala Glu Ile Phe Ser Pro Asn Asp Lys Lys Ser Phe Cys 
    610                 615                 620                 


Ser Ile Glu Gly Glu Trp Asn Gly Val Met Tyr Ala Lys Tyr Ala Thr 
625                 630                 635                 640 


Gly Glu Asn Thr Val Phe Val Asp Thr Lys Lys Leu Pro Ile Ile Lys 
                645                 650                 655     


Lys Lys Val Arg Lys Leu Glu Asp Gln Asn Glu Tyr Glu Ser Arg Ser 
            660                 665                 670         


Leu Trp Lys Asp Val Thr Phe Asn Leu Lys Ile Arg Asp Ile Asp Ala 
        675                 680                 685             


Ala Thr Glu Ala Lys His Arg Leu Glu Glu Arg Gln Arg Ala Glu Ala 
    690                 695                 700                 


Arg Glu Arg Lys Glu Lys Glu Ile Gln Trp Glu Thr Arg Leu Phe His 
705                 710                 715                 720 


Glu Asp Gly Glu Cys Trp Val Tyr Asp Glu Pro Leu Leu Lys Arg Leu 
                725                 730                 735     


Gly Ala Ala Lys His 
            740     


<210>  6353
<211>  3347
<212>  DNA
<213>  Homosapiens

<400>  6353
atgattataa gcttcctgag gcctccctag aagctgagca gatggcagaa ccatgcttcc     60

tgtaaatcct gcagaatcaa gaaggaactg agtctctaag atggaggata tacaactgac    120

aagtagtaaa gtcaagatac acagccagac agtgtctcag tctggcatcc aactcaggct    180

ggagtgcagt gacatgatct tggctcactg cagtcttgac ctcctgggct caagcaatcc    240

tcctgcctca gcttcctgag tagattataa ataatcttaa tagcagtatt cacgtttgca    300

ttctcgcatc cgtggcatgg agtcctacac acaataggcg ccctaagaaa gcgtgtttga    360

cttgatcgct ggagcatctg ccggcaccgc ccaggacccg cccaggaccc gccccgcccc    420

ctgcggcccc gccccccgca tgctgaatgc catataggcg agtgacgtca ggccgtttgt    480

tgtcattggc ggctcccaag atggcgtcca tcatggaagg gccgctgagc aaatggacta    540

acgtgatgaa gggctggcag taccgttggt tcgtgctgga ctacaatgca ggactgctct    600

cctactacac gtccaaggac aaaatgatga gaggctctcg cagaggatgt gttagactca    660

gaggagctgt gattggtata gacgatgagg acgacagcac cttcacaata actgttgatc    720

agaaaacctt ccatttccag gcccgtgatg ctgatgagcg agagaagtgg atccatgcct    780

tagaagaaac aattcttcga catactctcc agcttcaagg tttggattca ggatttgttc    840

ctagtgtcca agattttgat aagaaactta cagaagctga tgcttaccta caaatcttga    900

ttgaacaatt aaagcttttt gatgacaagc ttcaaaactg caaagaagat gaacagagaa    960

agaaaattga aactctcaaa gagacaacaa atagcatggt agaatcaatt aaacactgca   1020

ttgtgttgct gcagattgcc aaaagtacta ttaatcccgt agatgcaata tatcaaccta   1080

gtcctttgga acctgtgatc agcacaatgc cttcccagac tgtgttacct ccagaacctg   1140

ttcagttgtg taagtcagag cagcgtccat cttccctacc agttggacct gtgttggcta   1200

ccttgggaca tcatcagact cctacaccaa atagtacagg cagtggccat tcaccaccga   1260

gtagcagtct cacttctcca agccacgtga acttgtctcc aaatacagtc ccagagttct   1320

cttactccag cagtgaagat gaattttatg atgctgatga attccatcaa agtggctcat   1380

ccccaaagcg cttaatagat tcttctggat ctgcctcagt cctgacacac agcagctcgg   1440

gaaatagtct aaaacgccca gataccacag aatcacttaa ttcttccttg tccaatggaa   1500

caagtgatgc tgacctgttt gattcacatg atgacagaga tgatgatgcg gaggcagggt   1560

ctgtggagga gcacaagagc gttatcatgc atctcttgtc gcaggttaga cttggaatgg   1620

atcttactaa ggtagttctt ccaacgttta ttcttgaaag aagatctctt ttagaaatgt   1680

atgcagactt ttttgcacat ccggacctgt ttgtgagcat tagtgaccag aaggatccca   1740

aggatcgaat ggttcaggtt gtgaaatggt acctctcagc ctttcatgcg ggaaggaaag   1800

gatcagttgc caaaaagcca tacaatccca ttttgggcga gatttttcag tgtcattgga   1860

cattaccaaa tgatactgaa gagaacacag aactagtttc agaaggacca gttccctggg   1920

tttccaaaaa cagtgtaaca tttgtggctg agcaggtttc ccatcatcca cccatttcag   1980

ccttttatgc tgagtgtttt aacaagaaga tacaattcaa tgctcatatc tggaccaaat   2040

caaaattcct tgggatgtca attggggtgc acaacatagg gcagggctgt gtctcatgtc   2100

tagactatga tgaacattac attctcacat tccccaatgg ctatggaagg tctatcctca   2160

cagtgccctg ggtggaatta ggaggagaat gcaatattaa ttgttccaaa acaggctata   2220

gtgcaaatat catcttccac actaaaccct tctatggggg caagaagcac agaattactg   2280

ccgagatttt ttctccaaat gacaagaagt ctttttgctc aattgaaggg gaatggaatg   2340

gtgtgatgta tgcaaaatat gcaacagggg aaaatacagt ctttgtagat accaagaagt   2400

tgcctataat caagaagaaa gtgaggaagt tggaagatca gaacgagtat gaatcccgca   2460

gcctttggaa ggatgtcact ttcaacttaa aaatcagaga cattgatgca gcaactgaag   2520

caaagcacag gcttgaagaa agacaaagag cagaagcccg agaaaggaag gagaaggaaa   2580

ttcagtggga gacaaggtta tttcatgaag atggagaatg ctgggtttat gatgaaccat   2640

tactgaaacg tcttggtgct gccaagcatt aggttggaag atgcaaagtt tatacctgat   2700

gatcagggca gtaggcataa ttcagcaaca aacaatcttc ctttgggaga aacctgttca   2760

ttccaatctt ctaattacag tggttcctat ctcagggata ctggactttc tgacgcagat   2820

gaacaattaa ggggaaaagc ttcccttttc cctctgtggc agttacgatt ttgacttcag   2880

tcctgagaaa aacttcaggt tttgaaaatc agatgatgtc ttctcctttt ccaaacacca   2940

cacgttgaaa gcatttataa atccaagtct gaaactctgc gctctagtac tgctgttaag   3000

atacacaact tgtttcttag ttcatataat ctcgggatac acacacacac acacatatat   3060

atacacacac atacgtatac acacacatac atatatataa atatacctga tgccagattt   3120

ttttcataaa tattctgcct actgtaaata tgggttcctc tgagttgttt tagaaaatta   3180

gcgcaatgta ttaaaatcaa gtgttaggaa atttcatggt cttacctaca ataactttta   3240

ttttggaatt gaactattat taaattgtat ctaatcctgg attacagttt aattaattat   3300

tcttagtgct taaggcttca taaagtaatt tttccaacct ttttttt                 3347


<210>  6354
<211>  741
<212>  PRT
<213>  Homosapiens

<400>  6354

Met Pro Tyr Arg Arg Val Thr Ser Gly Arg Leu Leu Ser Leu Ala Ala 
1               5                   10                  15      


Pro Lys Met Ala Ser Ile Met Glu Gly Pro Leu Ser Lys Trp Thr Asn 
            20                  25                  30          


Val Met Lys Gly Trp Gln Tyr Arg Trp Phe Val Leu Asp Tyr Asn Ala 
        35                  40                  45              


Gly Leu Leu Ser Tyr Tyr Thr Ser Lys Asp Lys Met Met Arg Gly Ser 
    50                  55                  60                  


Arg Arg Gly Cys Val Arg Leu Arg Gly Ala Val Ile Gly Ile Asp Asp 
65                  70                  75                  80  


Glu Asp Asp Ser Thr Phe Thr Ile Thr Val Asp Gln Lys Thr Phe His 
                85                  90                  95      


Phe Gln Ala Arg Asp Ala Asp Glu Arg Glu Lys Trp Ile His Ala Leu 
            100                 105                 110         


Glu Glu Thr Ile Leu Arg His Thr Leu Gln Leu Gln Gly Leu Asp Ser 
        115                 120                 125             


Gly Phe Val Pro Ser Val Gln Asp Phe Asp Lys Lys Leu Thr Glu Ala 
    130                 135                 140                 


Asp Ala Tyr Leu Gln Ile Leu Ile Glu Gln Leu Lys Leu Phe Asp Asp 
145                 150                 155                 160 


Lys Leu Gln Asn Cys Lys Glu Asp Glu Gln Arg Lys Lys Ile Glu Thr 
                165                 170                 175     


Leu Lys Glu Thr Thr Asn Ser Met Val Glu Ser Ile Lys His Cys Ile 
            180                 185                 190         


Val Leu Leu Gln Ile Ala Lys Ser Thr Ile Asn Pro Val Asp Ala Ile 
        195                 200                 205             


Tyr Gln Pro Ser Pro Leu Glu Pro Val Ile Ser Thr Met Pro Ser Gln 
    210                 215                 220                 


Thr Val Leu Pro Pro Glu Pro Val Gln Leu Cys Lys Ser Glu Gln Arg 
225                 230                 235                 240 


Pro Ser Ser Leu Pro Val Gly Pro Val Leu Ala Thr Leu Gly His His 
                245                 250                 255     


Gln Thr Pro Thr Pro Asn Ser Thr Gly Ser Gly His Ser Pro Pro Ser 
            260                 265                 270         


Ser Ser Leu Thr Ser Pro Ser His Val Asn Leu Ser Pro Asn Thr Val 
        275                 280                 285             


Pro Glu Phe Ser Tyr Ser Ser Ser Glu Asp Glu Phe Tyr Asp Ala Asp 
    290                 295                 300                 


Glu Phe His Gln Ser Gly Ser Ser Pro Lys Arg Leu Ile Asp Ser Ser 
305                 310                 315                 320 


Gly Ser Ala Ser Val Leu Thr His Ser Ser Ser Gly Asn Ser Leu Lys 
                325                 330                 335     


Arg Pro Asp Thr Thr Glu Ser Leu Asn Ser Ser Leu Ser Asn Gly Thr 
            340                 345                 350         


Ser Asp Ala Asp Leu Phe Asp Ser His Asp Asp Arg Asp Asp Asp Ala 
        355                 360                 365             


Glu Ala Gly Ser Val Glu Glu His Lys Ser Val Ile Met His Leu Leu 
    370                 375                 380                 


Ser Gln Val Arg Leu Gly Met Asp Leu Thr Lys Val Val Leu Pro Thr 
385                 390                 395                 400 


Phe Ile Leu Glu Arg Arg Ser Leu Leu Glu Met Tyr Ala Asp Phe Phe 
                405                 410                 415     


Ala His Pro Asp Leu Phe Val Ser Ile Ser Asp Gln Lys Asp Pro Lys 
            420                 425                 430         


Asp Arg Met Val Gln Val Val Lys Trp Tyr Leu Ser Ala Phe His Ala 
        435                 440                 445             


Gly Arg Lys Gly Ser Val Ala Lys Lys Pro Tyr Asn Pro Ile Leu Gly 
    450                 455                 460                 


Glu Ile Phe Gln Cys His Trp Thr Leu Pro Asn Asp Thr Glu Glu Asn 
465                 470                 475                 480 


Thr Glu Leu Val Ser Glu Gly Pro Val Pro Trp Val Ser Lys Asn Ser 
                485                 490                 495     


Val Thr Phe Val Ala Glu Gln Val Ser His His Pro Pro Ile Ser Ala 
            500                 505                 510         


Phe Tyr Ala Glu Cys Phe Asn Lys Lys Ile Gln Phe Asn Ala His Ile 
        515                 520                 525             


Trp Thr Lys Ser Lys Phe Leu Gly Met Ser Ile Gly Val His Asn Ile 
    530                 535                 540                 


Gly Gln Gly Cys Val Ser Cys Leu Asp Tyr Asp Glu His Tyr Ile Leu 
545                 550                 555                 560 


Thr Phe Pro Asn Gly Tyr Gly Arg Ser Ile Leu Thr Val Pro Trp Val 
                565                 570                 575     


Glu Leu Gly Gly Glu Cys Asn Ile Asn Cys Ser Lys Thr Gly Tyr Ser 
            580                 585                 590         


Ala Asn Ile Ile Phe His Thr Lys Pro Phe Tyr Gly Gly Lys Lys His 
        595                 600                 605             


Arg Ile Thr Ala Glu Ile Phe Ser Pro Asn Asp Lys Lys Ser Phe Cys 
    610                 615                 620                 


Ser Ile Glu Gly Glu Trp Asn Gly Val Met Tyr Ala Lys Tyr Ala Thr 
625                 630                 635                 640 


Gly Glu Asn Thr Val Phe Val Asp Thr Lys Lys Leu Pro Ile Ile Lys 
                645                 650                 655     


Lys Lys Val Arg Lys Leu Glu Asp Gln Asn Glu Tyr Glu Ser Arg Ser 
            660                 665                 670         


Leu Trp Lys Asp Val Thr Phe Asn Leu Lys Ile Arg Asp Ile Asp Ala 
        675                 680                 685             


Ala Thr Glu Ala Lys His Arg Leu Glu Glu Arg Gln Arg Ala Glu Ala 
    690                 695                 700                 


Arg Glu Arg Lys Glu Lys Glu Ile Gln Trp Glu Thr Arg Leu Phe His 
705                 710                 715                 720 


Glu Asp Gly Glu Cys Trp Val Tyr Asp Glu Pro Leu Leu Lys Arg Leu 
                725                 730                 735     


Gly Ala Ala Lys His 
            740     


<210>  6355
<211>  5350
<212>  DNA
<213>  Homosapiens

<400>  6355
atgattataa gcttcctgag gcctccctag aagctgagca gatggcagaa ccatgcttcc     60

tgtaaatcct gcagaatcaa gaaggaactg agtctctaag atggaggata tacaactgac    120

aagtagtaaa gtcaagatac acagccagac agtgtctcag tctggcatcc aactcaggct    180

ggagtgcagt gacatgatct tggctcactg cagtcttgac ctcctgggct caagcaatcc    240

tcctgcctca gcttcctgag tagattataa ataatcttaa tagcagtatt cacgtttgca    300

ttctcgcatc cgtggcatgg agtcctacac acaataggcg ccctaagaaa gcgtgtttga    360

cttgatcgct ggagcatctg ccggcaccgc ccaggacccg cccaggaccc gccccgcccc    420

ctgcggcccc gccccccgca tgctgaatgc catataggcg agtgacgtca ggccgtttgt    480

tgtcattggc ggctcccaag atggcgtcca tcatggaagg gccgctgagc aaatggacta    540

acgtgatgaa gggctggcag taccgttggt tcgtgctgga ctacaatgca ggactgctct    600

cctactacac gtccaaggac aaaatgatga gaggctctcg cagaggatgt gttagactca    660

gaggagctgt gattggtata gacgatgagg acgacagcac cttcacaata actgttgatc    720

agaaaacctt ccatttccag gcccgtgatg ctgatgagcg agagaagtgg atccatgcct    780

tagaagaaac aattcttcga catactctcc agcttcaagg tttggattca ggatttgttc    840

ctagtgtcca agattttgat aagaaactta cagaagctga tgcttaccta caaatcttga    900

ttgaacaatt aaagcttttt gatgacaagc ttcaaaactg caaagaagat gaacagagaa    960

agaaaattga aactctcaaa gagacaacaa atagcatggt agaatcaatt aaacactgca   1020

ttgtgttgct gcagattgcc aaaagtacta ttaatcccgt agatgcaata tatcaaccta   1080

gtcctttgga acctgtgatc agcacaatgc cttcccagac tgtgttacct ccagaacctg   1140

ttcagttgtg taagtcagag cagcgtccat cttccctacc agttggacct gtgttggcta   1200

ccttgggaca tcatcagact cctacaccaa atagtacagg cagtggccat tcaccaccga   1260

gtagcagtct cacttctcca agccacgtga acttgtctcc aaatacagtc ccagagttct   1320

cttactccag cagtgaagat gaattttatg atgctgatga attccatcaa agtggctcat   1380

ccccaaagcg cttaatagat tcttctggat ctgcctcagt cctgacacac agcagctcgg   1440

gaaatagtct aaaacgccca gataccacag aatcacttaa ttcttccttg tccaatggaa   1500

caagtgatgc tgacctgttt gattcacatg atgacagaga tgatgatgcg gaggcagggt   1560

ctgtggagga gcacaagagc gttatcatgc atctcttgtc gcaggttaga cttggaatgg   1620

atcttactaa ggtagttctt ccaacgttta ttcttgaaag aagatctctt ttagaaatgt   1680

atgcagactt ttttgcacat ccggacctgt ttgtgagcat tagtgaccag aaggatccca   1740

aggatcgaat ggttcaggtt gtgaaatggt acctctcagc ctttcatgcg ggaaggaaag   1800

gatcagttgc caaaaagcca tacaatccca ttttgggcga gatttttcag tgtcattgga   1860

cattaccaaa tgatactgaa gagaacacag aactagtttc agaaggacca gttccctggg   1920

tttccaaaaa cagtgtaaca tttgtggctg agcaggtttc ccatcatcca cccatttcag   1980

ccttttatgc tgagtgtttt aacaagaaga tacaattcaa tgctcatatc tggaccaaat   2040

caaaattcct tgggatgtca attggggtgc acaacatagg gcagggctgt gtctcatgtc   2100

tagactatga tgaacattac attctcacat tccccaatgg ctatggaagg tctatcctca   2160

cagtgccctg ggtggaatta ggaggagaat gcaatattaa ttgttccaaa acaggctata   2220

gtgcaaatat catcttccac actaaaccct tctatggggg caagaagcac agaattactg   2280

ccgagatttt ttctccaaat gacaagaagt ctttttgctc aattgaaggg gaatggaatg   2340

gtgtgatgta tgcaaaatat gcaacagggg aaaatacagt ctttgtagat accaagaagt   2400

tgcctataat caagaagaaa gtgaggaagt tggaagatca gaacgagtat gaatcccgca   2460

gcctttggaa ggatgtcact ttcaacttaa aaatcagaga cattgatgca gcaactgaag   2520

caaagcacag gcttgaagaa agacaaagag cagaagcccg agaaaggaag gagaaggaaa   2580

ttcagtggga gacaaggtta tttcatgaag atggagaatg ctgggtttat gatgaaccat   2640

tactgaaacg tcttggtgct gccaagcatt aggttggaag atgcaaagtt tatacctgat   2700

gatcagggca gtaggcataa ttcagcaaca aacaatcttc ctttgggaga aacctgttca   2760

ttccaatctt ctaattacag tggttcctat ctcagggata ctggactttc tgacgcagat   2820

gaacaattaa ggggaaaagc ttcccttttc cctctgtggc agttacgatt ttgacttcag   2880

tcctgagaaa aacttcaggt tttgaaaatc agatgatgtc ttctcctttt ccaaacacca   2940

cacgttgaaa gcatttataa atccaagtct gaaactctgc gctctagtac tgctgttaag   3000

atacacaact tgtttcttag ttcatataat ctcgggatac acacacacac acacatatat   3060

atacacacac atacgtatac acacacatac atatatataa atatacctga tgccagattt   3120

ttttcataaa tattctgcct actgtaaata tgggttcctc tgagttgttt tagaaaatta   3180

gcgcaatgta ttaaaatcaa gtgttaggaa atttcatggt cttacctaca ataactttta   3240

ttttggaatt gaactattat taaattgtat ctaatcctgg attacagttt aattaattat   3300

tcttagtgct taaggcttca taaagtaatt tttccaacct tttttttaaa aatgtgcatc   3360

ttttattatc ttttatggtt aaacttggaa gccaattatt tggcaacctt gaatacaaga   3420

gctagctttt caaagaaaga cacttgaaat aatggaggat ccattctttt cctctgtcag   3480

attgtatgtt ctgtctttag cccctgccag gcaattcccc agaatcttca cttaactcat   3540

attgcacatg tagggctgcc taccaacatt ttatccaaaa atgttttatt gccttagagg   3600

gtttgggaag agtgtgtatt tatagatccc caccccacag tgaacaaaaa tagatagata   3660

gatagaataa aatgaatgcc acagcagcag atggctcatt ctgaagggaa atacagaact   3720

atatctatct atctatctat catctttttt atttaaaaat acattaaaaa aacaggtatt   3780

agtacctagc atttagttag ttattcaata tactggttac gtaaggcctt tcaagaagta   3840

gattctcagt ctgagaggac acaggccagg gcttctcaaa gtgctgctgc aggctttctg   3900

gtctcgcttg gcccattctg ctaattttcc tttgccagct cctacagtaa ccctgggttt   3960

attagtctca acaaaggata aaaagtaaat caaatgctat gatgccagtg caaaacttca   4020

atggaagccc taaggcagta gtataactaa ctccataaaa tacaaacaaa cacattttaa   4080

aatacacatt gcttcaggcc aacgtgactg cagtttattt atttgactat tttatggtag   4140

gggagaaggt tgagtgttgt tgtgaaagcc ctgatatcag taatggggat gatacaatct   4200

gccagcagag gagaggttgg caggtaggtc agctgcatca cttcacaaga agaatttgaa   4260

tcctcactag aaggggtacc atcctcttcc agttcatact tcccatatcc aacaacctga   4320

aagaggacaa agacaaaagt gaaaaatatg ctgaccagat ttaggggttt aagagttctg   4380

atgataacca cccaaactca ctcagtaaat gacaacccta gaatggatgg agttagttaa   4440

acatactcac atgaacgctg agcattttac ttcctggccc tctatgggcc ttgaaccagt   4500

tgaccaggtc tgattttgag aatgacttca gtgcttcaat cttacaaggg aagggaagat   4560

aggaaagaaa ttcaagaaga aagatagctc ttaaacctaa cccccaggca gatgtccctg   4620

gacctgctta gcatctgaag acctcatttt attcttccta ttctcaggtt acccctaacc   4680

ttccagacca aaacgatgat gaagctctct ggcatgcctt cacattttat accaatcatc   4740

tacaatggca agagaggtta gcagatgcta taattacagc taaataccat acactgagcc   4800

caacacccac atccccttag tgtcacctcc caattacatg gtagctgcat accacggctt   4860

gaggaaatct accttgcttc tattaagaaa actaaaatgt gttaagatga agcctcttac   4920

taaataacct ctttacatca cagagcaatg atgtcctatg gtaattcacc atgtaggggc   4980

tatgtattaa ccaaagtcac actggagtac aagatccaga tctttttcat aggttttact   5040

actttggaat agaagttgtc aaaacacatg cacttggaat aatgaactcc gtaaagacaa   5100

agagtcctca attttcttta aacggcaaaa ctctttttct ccacaaaatc ttgtagacct   5160

caatatatag cataaaaata gagctgctct gattgaaatt ggtggtggtg tggtaaggat   5220

tagcacccag ctcacgtggc cacctaaggt gctagagagg ccagtctgaa aactcaggaa   5280

gtgagcgagt aatcaggcca ggactagtgt ttcgagtttc tcttccacac aatgctggtg   5340

tgcacagacc                                                          5350


<210>  6356
<211>  741
<212>  PRT
<213>  Homosapiens

<400>  6356

Met Pro Tyr Arg Arg Val Thr Ser Gly Arg Leu Leu Ser Leu Ala Ala 
1               5                   10                  15      


Pro Lys Met Ala Ser Ile Met Glu Gly Pro Leu Ser Lys Trp Thr Asn 
            20                  25                  30          


Val Met Lys Gly Trp Gln Tyr Arg Trp Phe Val Leu Asp Tyr Asn Ala 
        35                  40                  45              


Gly Leu Leu Ser Tyr Tyr Thr Ser Lys Asp Lys Met Met Arg Gly Ser 
    50                  55                  60                  


Arg Arg Gly Cys Val Arg Leu Arg Gly Ala Val Ile Gly Ile Asp Asp 
65                  70                  75                  80  


Glu Asp Asp Ser Thr Phe Thr Ile Thr Val Asp Gln Lys Thr Phe His 
                85                  90                  95      


Phe Gln Ala Arg Asp Ala Asp Glu Arg Glu Lys Trp Ile His Ala Leu 
            100                 105                 110         


Glu Glu Thr Ile Leu Arg His Thr Leu Gln Leu Gln Gly Leu Asp Ser 
        115                 120                 125             


Gly Phe Val Pro Ser Val Gln Asp Phe Asp Lys Lys Leu Thr Glu Ala 
    130                 135                 140                 


Asp Ala Tyr Leu Gln Ile Leu Ile Glu Gln Leu Lys Leu Phe Asp Asp 
145                 150                 155                 160 


Lys Leu Gln Asn Cys Lys Glu Asp Glu Gln Arg Lys Lys Ile Glu Thr 
                165                 170                 175     


Leu Lys Glu Thr Thr Asn Ser Met Val Glu Ser Ile Lys His Cys Ile 
            180                 185                 190         


Val Leu Leu Gln Ile Ala Lys Ser Thr Ile Asn Pro Val Asp Ala Ile 
        195                 200                 205             


Tyr Gln Pro Ser Pro Leu Glu Pro Val Ile Ser Thr Met Pro Ser Gln 
    210                 215                 220                 


Thr Val Leu Pro Pro Glu Pro Val Gln Leu Cys Lys Ser Glu Gln Arg 
225                 230                 235                 240 


Pro Ser Ser Leu Pro Val Gly Pro Val Leu Ala Thr Leu Gly His His 
                245                 250                 255     


Gln Thr Pro Thr Pro Asn Ser Thr Gly Ser Gly His Ser Pro Pro Ser 
            260                 265                 270         


Ser Ser Leu Thr Ser Pro Ser His Val Asn Leu Ser Pro Asn Thr Val 
        275                 280                 285             


Pro Glu Phe Ser Tyr Ser Ser Ser Glu Asp Glu Phe Tyr Asp Ala Asp 
    290                 295                 300                 


Glu Phe His Gln Ser Gly Ser Ser Pro Lys Arg Leu Ile Asp Ser Ser 
305                 310                 315                 320 


Gly Ser Ala Ser Val Leu Thr His Ser Ser Ser Gly Asn Ser Leu Lys 
                325                 330                 335     


Arg Pro Asp Thr Thr Glu Ser Leu Asn Ser Ser Leu Ser Asn Gly Thr 
            340                 345                 350         


Ser Asp Ala Asp Leu Phe Asp Ser His Asp Asp Arg Asp Asp Asp Ala 
        355                 360                 365             


Glu Ala Gly Ser Val Glu Glu His Lys Ser Val Ile Met His Leu Leu 
    370                 375                 380                 


Ser Gln Val Arg Leu Gly Met Asp Leu Thr Lys Val Val Leu Pro Thr 
385                 390                 395                 400 


Phe Ile Leu Glu Arg Arg Ser Leu Leu Glu Met Tyr Ala Asp Phe Phe 
                405                 410                 415     


Ala His Pro Asp Leu Phe Val Ser Ile Ser Asp Gln Lys Asp Pro Lys 
            420                 425                 430         


Asp Arg Met Val Gln Val Val Lys Trp Tyr Leu Ser Ala Phe His Ala 
        435                 440                 445             


Gly Arg Lys Gly Ser Val Ala Lys Lys Pro Tyr Asn Pro Ile Leu Gly 
    450                 455                 460                 


Glu Ile Phe Gln Cys His Trp Thr Leu Pro Asn Asp Thr Glu Glu Asn 
465                 470                 475                 480 


Thr Glu Leu Val Ser Glu Gly Pro Val Pro Trp Val Ser Lys Asn Ser 
                485                 490                 495     


Val Thr Phe Val Ala Glu Gln Val Ser His His Pro Pro Ile Ser Ala 
            500                 505                 510         


Phe Tyr Ala Glu Cys Phe Asn Lys Lys Ile Gln Phe Asn Ala His Ile 
        515                 520                 525             


Trp Thr Lys Ser Lys Phe Leu Gly Met Ser Ile Gly Val His Asn Ile 
    530                 535                 540                 


Gly Gln Gly Cys Val Ser Cys Leu Asp Tyr Asp Glu His Tyr Ile Leu 
545                 550                 555                 560 


Thr Phe Pro Asn Gly Tyr Gly Arg Ser Ile Leu Thr Val Pro Trp Val 
                565                 570                 575     


Glu Leu Gly Gly Glu Cys Asn Ile Asn Cys Ser Lys Thr Gly Tyr Ser 
            580                 585                 590         


Ala Asn Ile Ile Phe His Thr Lys Pro Phe Tyr Gly Gly Lys Lys His 
        595                 600                 605             


Arg Ile Thr Ala Glu Ile Phe Ser Pro Asn Asp Lys Lys Ser Phe Cys 
    610                 615                 620                 


Ser Ile Glu Gly Glu Trp Asn Gly Val Met Tyr Ala Lys Tyr Ala Thr 
625                 630                 635                 640 


Gly Glu Asn Thr Val Phe Val Asp Thr Lys Lys Leu Pro Ile Ile Lys 
                645                 650                 655     


Lys Lys Val Arg Lys Leu Glu Asp Gln Asn Glu Tyr Glu Ser Arg Ser 
            660                 665                 670         


Leu Trp Lys Asp Val Thr Phe Asn Leu Lys Ile Arg Asp Ile Asp Ala 
        675                 680                 685             


Ala Thr Glu Ala Lys His Arg Leu Glu Glu Arg Gln Arg Ala Glu Ala 
    690                 695                 700                 


Arg Glu Arg Lys Glu Lys Glu Ile Gln Trp Glu Thr Arg Leu Phe His 
705                 710                 715                 720 


Glu Asp Gly Glu Cys Trp Val Tyr Asp Glu Pro Leu Leu Lys Arg Leu 
                725                 730                 735     


Gly Ala Ala Lys His 
            740     


<210>  6357
<211>  2905
<212>  DNA
<213>  Homosapiens

<400>  6357
gtcattggcg gctcccaaga tggcgtccat catggaaggg ccgctgagca aatggactaa     60

cgtgatgaag ggctggcagt accgttggtt cgtgctggac tacaatgcag gactgctctc    120

ctactacacg tccaaggaca aaatgatgag aggctctcgc agaggatgtg ttagactcag    180

aggagctgtg attggtatag acgatgagga cgacagcacc ttcacaataa ctgttgatca    240

gaaaaccttc catttccagg cccgtgatgc tgatgagcga gagaagtgga tccatgcctt    300

agaagaaaca attcttcgac atactctcca gcttcaaggt ttggattcag gatttgttcc    360

tagtgtccaa gattttgata agaaacttac agaagctgat gcttacctac aaatcttgat    420

tgaacaatta aagctttttg atgacaagct tcaaaactgc aaagaagatg aacagagaaa    480

gaaaattgaa actctcaaag agacaacaaa tagcatggta gaatcaatta aacactgcat    540

tgtgttgctg cagattgcca aagaccagag taatgcggag aagcacgcag atggaatgat    600

aagtactatt aatcccgtag atgcaatata tcaacctagt cctttggaac ctgtgatcag    660

cacaatgcct tcccagactg tgttacctcc agaacctgtt cagttgtgta agtcagagca    720

gcgtccatct tccctaccag ttggacctgt gttggctacc ttgggacatc atcagactcc    780

tacaccaaat agtacaggca gtggccattc accaccgagt agcagtctca cttctccaag    840

ccacgtgaac ttgtctccaa atacagtccc agagttctct tactccagca gtgaagatga    900

attttatgat gctgatgaat tccatcaaag tggctcatcc ccaaagcgct taatagattc    960

ttctggatct gcctcagtcc tgacacacag cagctcggga aatagtctaa aacgcccaga   1020

taccacagaa tcacttaatt cttccttgtc caatggaaca agtgatgctg acctgtttga   1080

ttcacatgat gacagagatg atgatgcgga ggcagggtct gtggaggagc acaagagcgt   1140

tatcatgcat ctcttgtcgc aggttagact tggaatggat cttactaagg tagttcttcc   1200

aacgtttatt cttgaaagaa gatctctttt agaaatgtat gcagactttt ttgcacatcc   1260

ggacctgttt gtgagcatta gtgaccagaa ggatcccaag gatcgaatgg ttcaggttgt   1320

gaaatggtac ctctcagcct ttcatgcggg aaggaaagga tcagttgcca aaaagccata   1380

caatcccatt ttgggcgaga tttttcagtg tcattggaca ttaccaaatg atactgaaga   1440

gaacacagaa ctagtttcag aaggaccagt tccctgggtt tccaaaaaca gtgtaacatt   1500

tgtggctgag caggtttccc atcatccacc catttcagcc ttttatgctg agtgttttaa   1560

caagaagata caattcaatg ctcatatctg gaccaaatca aaattccttg ggatgtcaat   1620

tggggtgcac aacatagggc agggctgtgt ctcatgtcta gactatgatg aacattacat   1680

tctcacattc cccaatggct atggaaggtc tatcctcaca gtgccctggg tggaattagg   1740

aggagaatgc aatattaatt gttccaaaac aggctatagt gcaaatatca tcttccacac   1800

taaacccttc tatgggggca agaagcacag aattactgcc gagatttttt ctccaaatga   1860

caagaagtct ttttgctcaa ttgaagggga atggaatggt gtgatgtatg caaaatatgc   1920

aacaggggaa aatacagtct ttgtagatac caagaagttg cctataatca agaagaaagt   1980

gaggaagttg gaagatcaga acgagtatga atcccgcagc ctttggaagg atgtcacttt   2040

caacttaaaa atcagagaca ttgatgcagc aactgaagca aagcacaggc ttgaagaaag   2100

acaaagagca gaagcccgag aaaggaagga gaaggaaatt cagtgggaga caaggttatt   2160

tcatgaagat ggagaatgct gggtttatga tgaaccatta ctgaaacgtc ttggtgctgc   2220

caagcattag gttggaagat gcaaagttta tacctgatga tcagggcagt aggcataatt   2280

cagcaacaaa caatcttcct ttgggagaaa cctgttcatt ccaatcttct aattacagtg   2340

gttcctatct cagggatact ggactttctg acgcagatga acaattaagg ggaaaagctt   2400

cccttttccc tctgtggcag ttacgatttt gacttcagtc ctgagaaaaa cttcaggttt   2460

tgaaaatcag atgatgtctt ctccttttcc aaacaccaca cgttgaaagc atttataaat   2520

ccaagtctga aactctgcgc tctagtactg ctgttaagat acacaacttg tttcttagtt   2580

catataatct cgggatacac acacacacac acatatatat acacacacat acgtatacac   2640

acacatacat atatataaat atacctgatg ccagattttt ttcataaata ttctgcctac   2700

tgtaaatatg ggttcctctg agttgtttta gaaaattagc gcaatgtatt aaaatcaagt   2760

gttaggaaat ttcatggtct tacctacaat aacttttatt ttggaattga actattatta   2820

aattgtatct aatcctggat tacagtttaa ttaattattc ttagtgctta aggcttcata   2880

aagtaatttt tccaaccttt ttttt                                         2905


<210>  6358
<211>  736
<212>  PRT
<213>  Homosapiens

<400>  6358

Met Ala Ser Ile Met Glu Gly Pro Leu Ser Lys Trp Thr Asn Val Met 
1               5                   10                  15      


Lys Gly Trp Gln Tyr Arg Trp Phe Val Leu Asp Tyr Asn Ala Gly Leu 
            20                  25                  30          


Leu Ser Tyr Tyr Thr Ser Lys Asp Lys Met Met Arg Gly Ser Arg Arg 
        35                  40                  45              


Gly Cys Val Arg Leu Arg Gly Ala Val Ile Gly Ile Asp Asp Glu Asp 
    50                  55                  60                  


Asp Ser Thr Phe Thr Ile Thr Val Asp Gln Lys Thr Phe His Phe Gln 
65                  70                  75                  80  


Ala Arg Asp Ala Asp Glu Arg Glu Lys Trp Ile His Ala Leu Glu Glu 
                85                  90                  95      


Thr Ile Leu Arg His Thr Leu Gln Leu Gln Gly Leu Asp Ser Gly Phe 
            100                 105                 110         


Val Pro Ser Val Gln Asp Phe Asp Lys Lys Leu Thr Glu Ala Asp Ala 
        115                 120                 125             


Tyr Leu Gln Ile Leu Ile Glu Gln Leu Lys Leu Phe Asp Asp Lys Leu 
    130                 135                 140                 


Gln Asn Cys Lys Glu Asp Glu Gln Arg Lys Lys Ile Glu Thr Leu Lys 
145                 150                 155                 160 


Glu Thr Thr Asn Ser Met Val Glu Ser Ile Lys His Cys Ile Val Leu 
                165                 170                 175     


Leu Gln Ile Ala Lys Asp Gln Ser Asn Ala Glu Lys His Ala Asp Gly 
            180                 185                 190         


Met Ile Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro 
        195                 200                 205             


Leu Glu Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val Leu Pro Pro 
    210                 215                 220                 


Glu Pro Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro 
225                 230                 235                 240 


Val Gly Pro Val Leu Ala Thr Leu Gly His His Gln Thr Pro Thr Pro 
                245                 250                 255     


Asn Ser Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser 
            260                 265                 270         


Pro Ser His Val Asn Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr 
        275                 280                 285             


Ser Ser Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe His Gln Ser 
    290                 295                 300                 


Gly Ser Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser Ala Ser Val 
305                 310                 315                 320 


Leu Thr His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr 
                325                 330                 335     


Glu Ser Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu 
            340                 345                 350         


Phe Asp Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val 
        355                 360                 365             


Glu Glu His Lys Ser Val Ile Met His Leu Leu Ser Gln Val Arg Leu 
    370                 375                 380                 


Gly Met Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile Leu Glu Arg 
385                 390                 395                 400 


Arg Ser Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu 
                405                 410                 415     


Phe Val Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg Met Val Gln 
            420                 425                 430         


Val Val Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser 
        435                 440                 445             


Val Ala Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys 
    450                 455                 460                 


His Trp Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser 
465                 470                 475                 480 


Glu Gly Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala 
                485                 490                 495     


Glu Gln Val Ser His His Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys 
            500                 505                 510         


Phe Asn Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr Lys Ser Lys 
        515                 520                 525             


Phe Leu Gly Met Ser Ile Gly Val His Asn Ile Gly Gln Gly Cys Val 
    530                 535                 540                 


Ser Cys Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe Pro Asn Gly 
545                 550                 555                 560 


Tyr Gly Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu 
                565                 570                 575     


Cys Asn Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe 
            580                 585                 590         


His Thr Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile Thr Ala Glu 
        595                 600                 605             


Ile Phe Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu 
    610                 615                 620                 


Trp Asn Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val 
625                 630                 635                 640 


Phe Val Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys Val Arg Lys 
                645                 650                 655     


Leu Glu Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val 
            660                 665                 670         


Thr Phe Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys 
        675                 680                 685             


His Arg Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu 
    690                 695                 700                 


Lys Glu Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp Gly Glu Cys 
705                 710                 715                 720 


Trp Val Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
                725                 730                 735     


<210>  6359
<211>  2935
<212>  DNA
<213>  Homosapiens

<400>  6359
gtcattggcg gctcccaaga tggcgtccat catggaaggg ccgctgagca aatggactaa     60

cgtgatgaag ggctggcagt accgttggtt cgtgctggac tacaatgcag gactgctctc    120

ctactacacg tccaaggaca aaatgatgag aggctctcgc agaggatgtg ttagactcag    180

aggagctgtg attggtatag acgatgagga cgacagcacc ttcacaataa ctgttgatca    240

gaaaaccttc catttccagg cccgtgatgc tgatgagcga gagaagtgga tccatgcctt    300

agaagaaaca attcttcgac atactctcca gcttcaaatc agtaccacac ttgctttttt    360

ccagtcttct ggtatctctc cagttcttga attttcaaaa ataattggtt tggattcagg    420

atttgttcct agtgtccaag attttgataa gaaacttaca gaagctgatg cttacctaca    480

aatcttgatt gaacaattaa agctttttga tgacaagctt caaaactgca aagaagatga    540

acagagaaag aaaattgaaa ctctcaaaga gacaacaaat agcatggtag aatcaattaa    600

acactgcatt gtgttgctgc agattgccaa aagtactatt aatcccgtag atgcaatata    660

tcaacctagt cctttggaac ctgtgatcag cacaatgcct tcccagactg tgttacctcc    720

agaacctgtt cagttgtgta agtcagagca gcgtccatct tccctaccag ttggacctgt    780

gttggctacc ttgggacatc atcagactcc tacaccaaat agtacaggca gtggccattc    840

accaccgagt agcagtctca cttctccaag ccacgtgaac ttgtctccaa atacagtccc    900

agagttctct tactccagca gtgaagatga attttatgat gctgatgaat tccatcaaag    960

tggctcatcc ccaaagcgct taatagattc ttctggatct gcctcagtcc tgacacacag   1020

cagctcggga aatagtctaa aacgcccaga taccacagaa tcacttaatt cttccttgtc   1080

caatggaaca agtgatgctg acctgtttga ttcacatgat gacagagatg atgatgcgga   1140

ggcagggtct gtggaggagc acaagagcgt tatcatgcat ctcttgtcgc aggttagact   1200

tggaatggat cttactaagg tagttcttcc aacgtttatt cttgaaagaa gatctctttt   1260

agaaatgtat gcagactttt ttgcacatcc ggacctgttt gtgagcatta gtgaccagaa   1320

ggatcccaag gatcgaatgg ttcaggttgt gaaatggtac ctctcagcct ttcatgcggg   1380

aaggaaagga tcagttgcca aaaagccata caatcccatt ttgggcgaga tttttcagtg   1440

tcattggaca ttaccaaatg atactgaaga gaacacagaa ctagtttcag aaggaccagt   1500

tccctgggtt tccaaaaaca gtgtaacatt tgtggctgag caggtttccc atcatccacc   1560

catttcagcc ttttatgctg agtgttttaa caagaagata caattcaatg ctcatatctg   1620

gaccaaatca aaattccttg ggatgtcaat tggggtgcac aacatagggc agggctgtgt   1680

ctcatgtcta gactatgatg aacattacat tctcacattc cccaatggct atggaaggtc   1740

tatcctcaca gtgccctggg tggaattagg aggagaatgc aatattaatt gttccaaaac   1800

aggctatagt gcaaatatca tcttccacac taaacccttc tatgggggca agaagcacag   1860

aattactgcc gagatttttt ctccaaatga caagaagtct ttttgctcaa ttgaagggga   1920

atggaatggt gtgatgtatg caaaatatgc aacaggggaa aatacagtct ttgtagatac   1980

caagaagttg cctataatca agaagaaagt gaggaagttg gaagatcaga acgagtatga   2040

atcccgcagc ctttggaagg atgtcacttt caacttaaaa atcagagaca ttgatgcagc   2100

aactgaagca aagcacaggc ttgaagaaag acaaagagca gaagcccgag aaaggaagga   2160

gaaggaaatt cagtgggaga caaggttatt tcatgaagat ggagaatgct gggtttatga   2220

tgaaccatta ctgaaacgtc ttggtgctgc caagcattag gttggaagat gcaaagttta   2280

tacctgatga tcagggcagt aggcataatt cagcaacaaa caatcttcct ttgggagaaa   2340

cctgttcatt ccaatcttct aattacagtg gttcctatct cagggatact ggactttctg   2400

acgcagatga acaattaagg ggaaaagctt cccttttccc tctgtggcag ttacgatttt   2460

gacttcagtc ctgagaaaaa cttcaggttt tgaaaatcag atgatgtctt ctccttttcc   2520

aaacaccaca cgttgaaagc atttataaat ccaagtctga aactctgcgc tctagtactg   2580

ctgttaagat acacaacttg tttcttagtt catataatct cgggatacac acacacacac   2640

acatatatat acacacacat acgtatacac acacatacat atatataaat atacctgatg   2700

ccagattttt ttcataaata ttctgcctac tgtaaatatg ggttcctctg agttgtttta   2760

gaaaattagc gcaatgtatt aaaatcaagt gttaggaaat ttcatggtct tacctacaat   2820

aacttttatt ttggaattga actattatta aattgtatct aatcctggat tacagtttaa   2880

ttaattattc ttagtgctta aggcttcata aagtaatttt tccaaccttt ttttt        2935


<210>  6360
<211>  746
<212>  PRT
<213>  Homosapiens

<400>  6360

Met Ala Ser Ile Met Glu Gly Pro Leu Ser Lys Trp Thr Asn Val Met 
1               5                   10                  15      


Lys Gly Trp Gln Tyr Arg Trp Phe Val Leu Asp Tyr Asn Ala Gly Leu 
            20                  25                  30          


Leu Ser Tyr Tyr Thr Ser Lys Asp Lys Met Met Arg Gly Ser Arg Arg 
        35                  40                  45              


Gly Cys Val Arg Leu Arg Gly Ala Val Ile Gly Ile Asp Asp Glu Asp 
    50                  55                  60                  


Asp Ser Thr Phe Thr Ile Thr Val Asp Gln Lys Thr Phe His Phe Gln 
65                  70                  75                  80  


Ala Arg Asp Ala Asp Glu Arg Glu Lys Trp Ile His Ala Leu Glu Glu 
                85                  90                  95      


Thr Ile Leu Arg His Thr Leu Gln Leu Gln Ile Ser Thr Thr Leu Ala 
            100                 105                 110         


Phe Phe Gln Ser Ser Gly Ile Ser Pro Val Leu Glu Phe Ser Lys Ile 
        115                 120                 125             


Ile Gly Leu Asp Ser Gly Phe Val Pro Ser Val Gln Asp Phe Asp Lys 
    130                 135                 140                 


Lys Leu Thr Glu Ala Asp Ala Tyr Leu Gln Ile Leu Ile Glu Gln Leu 
145                 150                 155                 160 


Lys Leu Phe Asp Asp Lys Leu Gln Asn Cys Lys Glu Asp Glu Gln Arg 
                165                 170                 175     


Lys Lys Ile Glu Thr Leu Lys Glu Thr Thr Asn Ser Met Val Glu Ser 
            180                 185                 190         


Ile Lys His Cys Ile Val Leu Leu Gln Ile Ala Lys Ser Thr Ile Asn 
        195                 200                 205             


Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro Leu Glu Pro Val Ile Ser 
    210                 215                 220                 


Thr Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro Val Gln Leu Cys 
225                 230                 235                 240 


Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly Pro Val Leu Ala 
                245                 250                 255     


Thr Leu Gly His His Gln Thr Pro Thr Pro Asn Ser Thr Gly Ser Gly 
            260                 265                 270         


His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser His Val Asn Leu 
        275                 280                 285             


Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser Ser Glu Asp Glu 
    290                 295                 300                 


Phe Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser Ser Pro Lys Arg 
305                 310                 315                 320 


Leu Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr His Ser Ser Ser 
                325                 330                 335     


Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser Leu Asn Ser Ser 
            340                 345                 350         


Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp Ser His Asp Asp 
        355                 360                 365             


Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu His Lys Ser Val 
    370                 375                 380                 


Ile Met His Leu Leu Ser Gln Val Arg Leu Gly Met Asp Leu Thr Lys 
385                 390                 395                 400 


Val Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser Leu Leu Glu Met 
                405                 410                 415     


Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val Ser Ile Ser Asp 
            420                 425                 430         


Gln Lys Asp Pro Lys Asp Arg Met Val Gln Val Val Lys Trp Tyr Leu 
        435                 440                 445             


Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala Lys Lys Pro Tyr 
    450                 455                 460                 


Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp Thr Leu Pro Asn 
465                 470                 475                 480 


Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly Pro Val Pro Trp 
                485                 490                 495     


Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln Val Ser His His 
            500                 505                 510         


Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn Lys Lys Ile Gln 
        515                 520                 525             


Phe Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu Gly Met Ser Ile 
    530                 535                 540                 


Gly Val His Asn Ile Gly Gln Gly Cys Val Ser Cys Leu Asp Tyr Asp 
545                 550                 555                 560 


Glu His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly Arg Ser Ile Leu 
                565                 570                 575     


Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn Ile Asn Cys Ser 
            580                 585                 590         


Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr Lys Pro Phe Tyr 
        595                 600                 605             


Gly Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe Ser Pro Asn Asp 
    610                 615                 620                 


Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn Gly Val Met Tyr 
625                 630                 635                 640 


Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val Asp Thr Lys Lys 
                645                 650                 655     


Leu Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu Asp Gln Asn Glu 
            660                 665                 670         


Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe Asn Leu Lys Ile 
        675                 680                 685             


Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg Leu Glu Glu Arg 
    690                 695                 700                 


Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu Ile Gln Trp Glu 
705                 710                 715                 720 


Thr Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val Tyr Asp Glu Pro 
                725                 730                 735     


Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
            740                 745     


<210>  6361
<211>  2775
<212>  DNA
<213>  Homosapiens

<400>  6361
gtcattggcg gctcccaaga tggcgtccat catggaaggg ccgctgagca aatggactaa     60

cgtgatgaag ggctggcagt accgttggtt cgtgctggac tacaatgcag gactgctctc    120

ctactacacg cccgtgatgc tgatgagcga gagaagtgga tccatgcctt agaagaaaca    180

attcttcgac atactctcca gcttcaaggt ttggattcag gatttgttcc tagtgtccaa    240

gattttgata agaaacttac agaagctgat gcttacctac aaatcttgat tgaacaatta    300

aagctttttg atgacaagct tcaaaactgc aaagaagatg aacagagaaa gaaaattgaa    360

actctcaaag agacaacaaa tagcatggta gaatcaatta aacactgcat tgtgttgctg    420

cagattgcca aagaccagag taatgcggag aagcacgcag atggaatgat aagtactatt    480

aatcccgtag atgcaatata tcaacctagt cctttggaac ctgtgatcag cacaatgcct    540

tcccagactg tgttacctcc agaacctgtt cagttgtgta agtcagagca gcgtccatct    600

tccctaccag ttggacctgt gttggctacc ttgggacatc atcagactcc tacaccaaat    660

agtacaggca gtggccattc accaccgagt agcagtctca cttctccaag ccacgtgaac    720

ttgtctccaa atacagtccc agagttctct tactccagca gtgaagatga attttatgat    780

gctgatgaat tccatcaaag tggctcatcc ccaaagcgct taatagattc ttctggatct    840

gcctcagtcc tgacacacag cagctcggga aatagtctaa aacgcccaga taccacagaa    900

tcacttaatt cttccttgtc caatggaaca agtgatgctg acctgtttga ttcacatgat    960

gacagagatg atgatgcgga ggcagggtct gtggaggagc acaagagcgt tatcatgcat   1020

ctcttgtcgc aggttagact tggaatggat cttactaagg tagttcttcc aacgtttatt   1080

cttgaaagaa gatctctttt agaaatgtat gcagactttt ttgcacatcc ggacctgttt   1140

gtgagcatta gtgaccagaa ggatcccaag gatcgaatgg ttcaggttgt gaaatggtac   1200

ctctcagcct ttcatgcggg aaggaaagga tcagttgcca aaaagccata caatcccatt   1260

ttgggcgaga tttttcagtg tcattggaca ttaccaaatg atactgaaga gaacacagaa   1320

ctagtttcag aaggaccagt tccctgggtt tccaaaaaca gtgtaacatt tgtggctgag   1380

caggtttccc atcatccacc catttcagcc ttttatgctg agtgttttaa caagaagata   1440

caattcaatg ctcatatctg gaccaaatca aaattccttg ggatgtcaat tggggtgcac   1500

aacatagggc agggctgtgt ctcatgtcta gactatgatg aacattacat tctcacattc   1560

cccaatggct atggaaggtc tatcctcaca gtgccctggg tggaattagg aggagaatgc   1620

aatattaatt gttccaaaac aggctatagt gcaaatatca tcttccacac taaacccttc   1680

tatgggggca agaagcacag aattactgcc gagatttttt ctccaaatga caagaagtct   1740

ttttgctcaa ttgaagggga atggaatggt gtgatgtatg caaaatatgc aacaggggaa   1800

aatacagtct ttgtagatac caagaagttg cctataatca agaagaaagt gaggaagttg   1860

gaagatcaga acgagtatga atcccgcagc ctttggaagg atgtcacttt caacttaaaa   1920

atcagagaca ttgatgcagc aactgaagca aagcacaggc ttgaagaaag acaaagagca   1980

gaagcccgag aaaggaagga gaaggaaatt cagtgggaga caaggttatt tcatgaagat   2040

ggagaatgct gggtttatga tgaaccatta ctgaaacgtc ttggtgctgc caagcattag   2100

gttggaagat gcaaagttta tacctgatga tcagggcagt aggcataatt cagcaacaaa   2160

caatcttcct ttgggagaaa cctgttcatt ccaatcttct aattacagtg gttcctatct   2220

cagggatact ggactttctg acgcagatga acaattaagg ggaaaagctt cccttttccc   2280

tctgtggcag ttacgatttt gacttcagtc ctgagaaaaa cttcaggttt tgaaaatcag   2340

atgatgtctt ctccttttcc aaacaccaca cgttgaaagc atttataaat ccaagtctga   2400

aactctgcgc tctagtactg ctgttaagat acacaacttg tttcttagtt catataatct   2460

cgggatacac acacacacac acatatatat acacacacat acgtatacac acacatacat   2520

atatataaat atacctgatg ccagattttt ttcataaata ttctgcctac tgtaaatatg   2580

ggttcctctg agttgtttta gaaaattagc gcaatgtatt aaaatcaagt gttaggaaat   2640

ttcatggtct tacctacaat aacttttatt ttggaattga actattatta aattgtatct   2700

aatcctggat tacagtttaa ttaattattc ttagtgctta aggcttcata aagtaatttt   2760

tccaaccttt ttttt                                                    2775


<210>  6362
<211>  571
<212>  PRT
<213>  Homosapiens

<400>  6362

Met Val Glu Ser Ile Lys His Cys Ile Val Leu Leu Gln Ile Ala Lys 
1               5                   10                  15      


Asp Gln Ser Asn Ala Glu Lys His Ala Asp Gly Met Ile Ser Thr Ile 
            20                  25                  30          


Asn Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro Leu Glu Pro Val Ile 
        35                  40                  45              


Ser Thr Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro Val Gln Leu 
    50                  55                  60                  


Cys Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly Pro Val Leu 
65                  70                  75                  80  


Ala Thr Leu Gly His His Gln Thr Pro Thr Pro Asn Ser Thr Gly Ser 
                85                  90                  95      


Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser His Val Asn 
            100                 105                 110         


Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser Ser Glu Asp 
        115                 120                 125             


Glu Phe Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser Ser Pro Lys 
    130                 135                 140                 


Arg Leu Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr His Ser Ser 
145                 150                 155                 160 


Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser Leu Asn Ser 
                165                 170                 175     


Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp Ser His Asp 
            180                 185                 190         


Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu His Lys Ser 
        195                 200                 205             


Val Ile Met His Leu Leu Ser Gln Val Arg Leu Gly Met Asp Leu Thr 
    210                 215                 220                 


Lys Val Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser Leu Leu Glu 
225                 230                 235                 240 


Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val Ser Ile Ser 
                245                 250                 255     


Asp Gln Lys Asp Pro Lys Asp Arg Met Val Gln Val Val Lys Trp Tyr 
            260                 265                 270         


Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala Lys Lys Pro 
        275                 280                 285             


Tyr Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp Thr Leu Pro 
    290                 295                 300                 


Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly Pro Val Pro 
305                 310                 315                 320 


Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln Val Ser His 
                325                 330                 335     


His Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn Lys Lys Ile 
            340                 345                 350         


Gln Phe Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu Gly Met Ser 
        355                 360                 365             


Ile Gly Val His Asn Ile Gly Gln Gly Cys Val Ser Cys Leu Asp Tyr 
    370                 375                 380                 


Asp Glu His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly Arg Ser Ile 
385                 390                 395                 400 


Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn Ile Asn Cys 
                405                 410                 415     


Ser Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr Lys Pro Phe 
            420                 425                 430         


Tyr Gly Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe Ser Pro Asn 
        435                 440                 445             


Asp Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn Gly Val Met 
    450                 455                 460                 


Tyr Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val Asp Thr Lys 
465                 470                 475                 480 


Lys Leu Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu Asp Gln Asn 
                485                 490                 495     


Glu Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe Asn Leu Lys 
            500                 505                 510         


Ile Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg Leu Glu Glu 
        515                 520                 525             


Arg Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu Ile Gln Trp 
    530                 535                 540                 


Glu Thr Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val Tyr Asp Glu 
545                 550                 555                 560 


Pro Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
                565                 570     


<210>  6363
<211>  4938
<212>  DNA
<213>  Homosapiens

<400>  6363
gtcattggcg gctcccaaga tggcgtccat catggaaggg ccgctgagca aatggactaa     60

cgtgatgaag ggctggcagt accgttggtt cgtgctggac tacaatgcag gactgctctc    120

ctactacacg tccaaggaca aaatgatgag aggctctcgc agaggatgtg ttagactcag    180

aggagctgtg attggtatag acgatgagga cgacagcacc ttcacaataa ctgttgatca    240

gaaaaccttc catttccagg cccgtgatgc tgatgagcga gagaagtgga tccatgcctt    300

agaagaaaca attcttcgac atactctcca gcttcaaatc agtaccacac ttgctttttt    360

ccagtcttct ggtatctctc cagttcttga attttcaaaa ataattggtt tggattcagg    420

atttgttcct agtgtccaag attttgataa gaaacttaca gaagctgatg cttacctaca    480

aatcttgatt gaacaattaa agctttttga tgacaagctt caaaactgca aagaagatga    540

acagagaaag aaaattgaaa ctctcaaaga gacaacaaat agcatggtag aatcaattaa    600

acactgcatt gtgttgctgc agattgccaa aagtactatt aatcccgtag atgcaatata    660

tcaacctagt cctttggaac ctgtgatcag cacaatgcct tcccagactg tgttacctcc    720

agaacctgtt cagttgtgta agtcagagca gcgtccatct tccctaccag ttggacctgt    780

gttggctacc ttgggacatc atcagactcc tacaccaaat agtacaggca gtggccattc    840

accaccgagt agcagtctca cttctccaag ccacgtgaac ttgtctccaa atacagtccc    900

agagttctct tactccagca gtgaagatga attttatgat gctgatgaat tccatcaaag    960

tggctcatcc ccaaagcgct taatagattc ttctggatct gcctcagtcc tgacacacag   1020

cagctcggga aatagtctaa aacgcccaga taccacagaa tcacttaatt cttccttgtc   1080

caatggaaca agtgatgctg acctgtttga ttcacatgat gacagagatg atgatgcgga   1140

ggcagggtct gtggaggagc acaagagcgt tatcatgcat ctcttgtcgc aggttagact   1200

tggaatggat cttactaagg tagttcttcc aacgtttatt cttgaaagaa gatctctttt   1260

agaaatgtat gcagactttt ttgcacatcc ggacctgttt gtgagcatta gtgaccagaa   1320

ggatcccaag gatcgaatgg ttcaggttgt gaaatggtac ctctcagcct ttcatgcggg   1380

aaggaaagga tcagttgcca aaaagccata caatcccatt ttgggcgaga tttttcagtg   1440

tcattggaca ttaccaaatg atactgaaga gaacacagaa ctagtttcag aaggaccagt   1500

tccctgggtt tccaaaaaca gtgtaacatt tgtggctgag caggtttccc atcatccacc   1560

catttcagcc ttttatgctg agtgttttaa caagaagata caattcaatg ctcatatctg   1620

gaccaaatca aaattccttg ggatgtcaat tggggtgcac aacatagggc agggctgtgt   1680

ctcatgtcta gactatgatg aacattacat tctcacattc cccaatggct atggaaggtc   1740

tatcctcaca gtgccctggg tggaattagg aggagaatgc aatattaatt gttccaaaac   1800

aggctatagt gcaaatatca tcttccacac taaacccttc tatgggggca agaagcacag   1860

aattactgcc gagatttttt ctccaaatga caagaagtct ttttgctcaa ttgaagggga   1920

atggaatggt gtgatgtatg caaaatatgc aacaggggaa aatacagtct ttgtagatac   1980

caagaagttg cctataatca agaagaaagt gaggaagttg gaagatcaga acgagtatga   2040

atcccgcagc ctttggaagg atgtcacttt caacttaaaa atcagagaca ttgatgcagc   2100

aactgaagca aagcacaggc ttgaagaaag acaaagagca gaagcccgag aaaggaagga   2160

gaaggaaatt cagtgggaga caaggttatt tcatgaagat ggagaatgct gggtttatga   2220

tgaaccatta ctgaaacgtc ttggtgctgc caagcattag gttggaagat gcaaagttta   2280

tacctgatga tcagggcagt aggcataatt cagcaacaaa caatcttcct ttgggagaaa   2340

cctgttcatt ccaatcttct aattacagtg gttcctatct cagggatact ggactttctg   2400

acgcagatga acaattaagg ggaaaagctt cccttttccc tctgtggcag ttacgatttt   2460

gacttcagtc ctgagaaaaa cttcaggttt tgaaaatcag atgatgtctt ctccttttcc   2520

aaacaccaca cgttgaaagc atttataaat ccaagtctga aactctgcgc tctagtactg   2580

ctgttaagat acacaacttg tttcttagtt catataatct cgggatacac acacacacac   2640

acatatatat acacacacat acgtatacac acacatacat atatataaat atacctgatg   2700

ccagattttt ttcataaata ttctgcctac tgtaaatatg ggttcctctg agttgtttta   2760

gaaaattagc gcaatgtatt aaaatcaagt gttaggaaat ttcatggtct tacctacaat   2820

aacttttatt ttggaattga actattatta aattgtatct aatcctggat tacagtttaa   2880

ttaattattc ttagtgctta aggcttcata aagtaatttt tccaaccttt tttttaaaaa   2940

tgtgcatctt ttattatctt ttatggttaa acttggaagc caattatttg gcaaccttga   3000

atacaagagc tagcttttca aagaaagaca cttgaaataa tggaggatcc attcttttcc   3060

tctgtcagat tgtatgttct gtctttagcc cctgccaggc aattccccag aatcttcact   3120

taactcatat tgcacatgta gggctgccta ccaacatttt atccaaaaat gttttattgc   3180

cttagagggt ttgggaagag tgtgtattta tagatcccca ccccacagtg aacaaaaata   3240

gatagataga tagaataaaa tgaatgccac agcagcagat ggctcattct gaagggaaat   3300

acagaactat atctatctat ctatctatca tcttttttat ttaaaaatac attaaaaaaa   3360

caggtattag tacctagcat ttagttagtt attcaatata ctggttacgt aaggcctttc   3420

aagaagtaga ttctcagtct gagaggacac aggccagggc ttctcaaagt gctgctgcag   3480

gctttctggt ctcgcttggc ccattctgct aattttcctt tgccagctcc tacagtaacc   3540

ctgggtttat tagtctcaac aaaggataaa aagtaaatca aatgctatga tgccagtgca   3600

aaacttcaat ggaagcccta aggcagtagt ataactaact ccataaaata caaacaaaca   3660

cattttaaaa tacacattgc ttcaggccaa cgtgactgca gtttatttat ttgactattt   3720

tatggtaggg gagaaggttg agtgttgttg tgaaagccct gatatcagta atggggatga   3780

tacaatctgc cagcagagga gaggttggca ggtaggtcag ctgcatcact tcacaagaag   3840

aatttgaatc ctcactagaa ggggtaccat cctcttccag ttcatacttc ccatatccaa   3900

caacctgaaa gaggacaaag acaaaagtga aaaatatgct gaccagattt aggggtttaa   3960

gagttctgat gataaccacc caaactcact cagtaaatga caaccctaga atggatggag   4020

ttagttaaac atactcacat gaacgctgag cattttactt cctggccctc tatgggcctt   4080

gaaccagttg accaggtctg attttgagaa tgacttcagt gcttcaatct tacaagggaa   4140

gggaagatag gaaagaaatt caagaagaaa gatagctctt aaacctaacc cccaggcaga   4200

tgtccctgga cctgcttagc atctgaagac ctcattttat tcttcctatt ctcaggttac   4260

ccctaacctt ccagaccaaa acgatgatga agctctctgg catgccttca cattttatac   4320

caatcatcta caatggcaag agaggttagc agatgctata attacagcta aataccatac   4380

actgagccca acacccacat ccccttagtg tcacctccca attacatggt agctgcatac   4440

cacggcttga ggaaatctac cttgcttcta ttaagaaaac taaaatgtgt taagatgaag   4500

cctcttacta aataacctct ttacatcaca gagcaatgat gtcctatggt aattcaccat   4560

gtaggggcta tgtattaacc aaagtcacac tggagtacaa gatccagatc tttttcatag   4620

gttttactac tttggaatag aagttgtcaa aacacatgca cttggaataa tgaactccgt   4680

aaagacaaag agtcctcaat tttctttaaa cggcaaaact ctttttctcc acaaaatctt   4740

gtagacctca atatatagca taaaaataga gctgctctga ttgaaattgg tggtggtgtg   4800

gtaaggatta gcacccagct cacgtggcca cctaaggtgc tagagaggcc agtctgaaaa   4860

ctcaggaagt gagcgagtaa tcaggccagg actagtgttt cgagtttctc ttccacacaa   4920

tgctggtgtg cacagacc                                                 4938


<210>  6364
<211>  746
<212>  PRT
<213>  Homosapiens

<400>  6364

Met Ala Ser Ile Met Glu Gly Pro Leu Ser Lys Trp Thr Asn Val Met 
1               5                   10                  15      


Lys Gly Trp Gln Tyr Arg Trp Phe Val Leu Asp Tyr Asn Ala Gly Leu 
            20                  25                  30          


Leu Ser Tyr Tyr Thr Ser Lys Asp Lys Met Met Arg Gly Ser Arg Arg 
        35                  40                  45              


Gly Cys Val Arg Leu Arg Gly Ala Val Ile Gly Ile Asp Asp Glu Asp 
    50                  55                  60                  


Asp Ser Thr Phe Thr Ile Thr Val Asp Gln Lys Thr Phe His Phe Gln 
65                  70                  75                  80  


Ala Arg Asp Ala Asp Glu Arg Glu Lys Trp Ile His Ala Leu Glu Glu 
                85                  90                  95      


Thr Ile Leu Arg His Thr Leu Gln Leu Gln Ile Ser Thr Thr Leu Ala 
            100                 105                 110         


Phe Phe Gln Ser Ser Gly Ile Ser Pro Val Leu Glu Phe Ser Lys Ile 
        115                 120                 125             


Ile Gly Leu Asp Ser Gly Phe Val Pro Ser Val Gln Asp Phe Asp Lys 
    130                 135                 140                 


Lys Leu Thr Glu Ala Asp Ala Tyr Leu Gln Ile Leu Ile Glu Gln Leu 
145                 150                 155                 160 


Lys Leu Phe Asp Asp Lys Leu Gln Asn Cys Lys Glu Asp Glu Gln Arg 
                165                 170                 175     


Lys Lys Ile Glu Thr Leu Lys Glu Thr Thr Asn Ser Met Val Glu Ser 
            180                 185                 190         


Ile Lys His Cys Ile Val Leu Leu Gln Ile Ala Lys Ser Thr Ile Asn 
        195                 200                 205             


Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro Leu Glu Pro Val Ile Ser 
    210                 215                 220                 


Thr Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro Val Gln Leu Cys 
225                 230                 235                 240 


Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly Pro Val Leu Ala 
                245                 250                 255     


Thr Leu Gly His His Gln Thr Pro Thr Pro Asn Ser Thr Gly Ser Gly 
            260                 265                 270         


His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser His Val Asn Leu 
        275                 280                 285             


Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser Ser Glu Asp Glu 
    290                 295                 300                 


Phe Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser Ser Pro Lys Arg 
305                 310                 315                 320 


Leu Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr His Ser Ser Ser 
                325                 330                 335     


Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser Leu Asn Ser Ser 
            340                 345                 350         


Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp Ser His Asp Asp 
        355                 360                 365             


Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu His Lys Ser Val 
    370                 375                 380                 


Ile Met His Leu Leu Ser Gln Val Arg Leu Gly Met Asp Leu Thr Lys 
385                 390                 395                 400 


Val Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser Leu Leu Glu Met 
                405                 410                 415     


Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val Ser Ile Ser Asp 
            420                 425                 430         


Gln Lys Asp Pro Lys Asp Arg Met Val Gln Val Val Lys Trp Tyr Leu 
        435                 440                 445             


Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala Lys Lys Pro Tyr 
    450                 455                 460                 


Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp Thr Leu Pro Asn 
465                 470                 475                 480 


Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly Pro Val Pro Trp 
                485                 490                 495     


Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln Val Ser His His 
            500                 505                 510         


Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn Lys Lys Ile Gln 
        515                 520                 525             


Phe Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu Gly Met Ser Ile 
    530                 535                 540                 


Gly Val His Asn Ile Gly Gln Gly Cys Val Ser Cys Leu Asp Tyr Asp 
545                 550                 555                 560 


Glu His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly Arg Ser Ile Leu 
                565                 570                 575     


Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn Ile Asn Cys Ser 
            580                 585                 590         


Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr Lys Pro Phe Tyr 
        595                 600                 605             


Gly Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe Ser Pro Asn Asp 
    610                 615                 620                 


Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn Gly Val Met Tyr 
625                 630                 635                 640 


Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val Asp Thr Lys Lys 
                645                 650                 655     


Leu Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu Asp Gln Asn Glu 
            660                 665                 670         


Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe Asn Leu Lys Ile 
        675                 680                 685             


Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg Leu Glu Glu Arg 
    690                 695                 700                 


Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu Ile Gln Trp Glu 
705                 710                 715                 720 


Thr Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val Tyr Asp Glu Pro 
                725                 730                 735     


Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
            740                 745     


<210>  6365
<211>  4778
<212>  DNA
<213>  Homosapiens

<400>  6365
gtcattggcg gctcccaaga tggcgtccat catggaaggg ccgctgagca aatggactaa     60

cgtgatgaag ggctggcagt accgttggtt cgtgctggac tacaatgcag gactgctctc    120

ctactacacg cccgtgatgc tgatgagcga gagaagtgga tccatgcctt agaagaaaca    180

attcttcgac atactctcca gcttcaaggt ttggattcag gatttgttcc tagtgtccaa    240

gattttgata agaaacttac agaagctgat gcttacctac aaatcttgat tgaacaatta    300

aagctttttg atgacaagct tcaaaactgc aaagaagatg aacagagaaa gaaaattgaa    360

actctcaaag agacaacaaa tagcatggta gaatcaatta aacactgcat tgtgttgctg    420

cagattgcca aagaccagag taatgcggag aagcacgcag atggaatgat aagtactatt    480

aatcccgtag atgcaatata tcaacctagt cctttggaac ctgtgatcag cacaatgcct    540

tcccagactg tgttacctcc agaacctgtt cagttgtgta agtcagagca gcgtccatct    600

tccctaccag ttggacctgt gttggctacc ttgggacatc atcagactcc tacaccaaat    660

agtacaggca gtggccattc accaccgagt agcagtctca cttctccaag ccacgtgaac    720

ttgtctccaa atacagtccc agagttctct tactccagca gtgaagatga attttatgat    780

gctgatgaat tccatcaaag tggctcatcc ccaaagcgct taatagattc ttctggatct    840

gcctcagtcc tgacacacag cagctcggga aatagtctaa aacgcccaga taccacagaa    900

tcacttaatt cttccttgtc caatggaaca agtgatgctg acctgtttga ttcacatgat    960

gacagagatg atgatgcgga ggcagggtct gtggaggagc acaagagcgt tatcatgcat   1020

ctcttgtcgc aggttagact tggaatggat cttactaagg tagttcttcc aacgtttatt   1080

cttgaaagaa gatctctttt agaaatgtat gcagactttt ttgcacatcc ggacctgttt   1140

gtgagcatta gtgaccagaa ggatcccaag gatcgaatgg ttcaggttgt gaaatggtac   1200

ctctcagcct ttcatgcggg aaggaaagga tcagttgcca aaaagccata caatcccatt   1260

ttgggcgaga tttttcagtg tcattggaca ttaccaaatg atactgaaga gaacacagaa   1320

ctagtttcag aaggaccagt tccctgggtt tccaaaaaca gtgtaacatt tgtggctgag   1380

caggtttccc atcatccacc catttcagcc ttttatgctg agtgttttaa caagaagata   1440

caattcaatg ctcatatctg gaccaaatca aaattccttg ggatgtcaat tggggtgcac   1500

aacatagggc agggctgtgt ctcatgtcta gactatgatg aacattacat tctcacattc   1560

cccaatggct atggaaggtc tatcctcaca gtgccctggg tggaattagg aggagaatgc   1620

aatattaatt gttccaaaac aggctatagt gcaaatatca tcttccacac taaacccttc   1680

tatgggggca agaagcacag aattactgcc gagatttttt ctccaaatga caagaagtct   1740

ttttgctcaa ttgaagggga atggaatggt gtgatgtatg caaaatatgc aacaggggaa   1800

aatacagtct ttgtagatac caagaagttg cctataatca agaagaaagt gaggaagttg   1860

gaagatcaga acgagtatga atcccgcagc ctttggaagg atgtcacttt caacttaaaa   1920

atcagagaca ttgatgcagc aactgaagca aagcacaggc ttgaagaaag acaaagagca   1980

gaagcccgag aaaggaagga gaaggaaatt cagtgggaga caaggttatt tcatgaagat   2040

ggagaatgct gggtttatga tgaaccatta ctgaaacgtc ttggtgctgc caagcattag   2100

gttggaagat gcaaagttta tacctgatga tcagggcagt aggcataatt cagcaacaaa   2160

caatcttcct ttgggagaaa cctgttcatt ccaatcttct aattacagtg gttcctatct   2220

cagggatact ggactttctg acgcagatga acaattaagg ggaaaagctt cccttttccc   2280

tctgtggcag ttacgatttt gacttcagtc ctgagaaaaa cttcaggttt tgaaaatcag   2340

atgatgtctt ctccttttcc aaacaccaca cgttgaaagc atttataaat ccaagtctga   2400

aactctgcgc tctagtactg ctgttaagat acacaacttg tttcttagtt catataatct   2460

cgggatacac acacacacac acatatatat acacacacat acgtatacac acacatacat   2520

atatataaat atacctgatg ccagattttt ttcataaata ttctgcctac tgtaaatatg   2580

ggttcctctg agttgtttta gaaaattagc gcaatgtatt aaaatcaagt gttaggaaat   2640

ttcatggtct tacctacaat aacttttatt ttggaattga actattatta aattgtatct   2700

aatcctggat tacagtttaa ttaattattc ttagtgctta aggcttcata aagtaatttt   2760

tccaaccttt tttttaaaaa tgtgcatctt ttattatctt ttatggttaa acttggaagc   2820

caattatttg gcaaccttga atacaagagc tagcttttca aagaaagaca cttgaaataa   2880

tggaggatcc attcttttcc tctgtcagat tgtatgttct gtctttagcc cctgccaggc   2940

aattccccag aatcttcact taactcatat tgcacatgta gggctgccta ccaacatttt   3000

atccaaaaat gttttattgc cttagagggt ttgggaagag tgtgtattta tagatcccca   3060

ccccacagtg aacaaaaata gatagataga tagaataaaa tgaatgccac agcagcagat   3120

ggctcattct gaagggaaat acagaactat atctatctat ctatctatca tcttttttat   3180

ttaaaaatac attaaaaaaa caggtattag tacctagcat ttagttagtt attcaatata   3240

ctggttacgt aaggcctttc aagaagtaga ttctcagtct gagaggacac aggccagggc   3300

ttctcaaagt gctgctgcag gctttctggt ctcgcttggc ccattctgct aattttcctt   3360

tgccagctcc tacagtaacc ctgggtttat tagtctcaac aaaggataaa aagtaaatca   3420

aatgctatga tgccagtgca aaacttcaat ggaagcccta aggcagtagt ataactaact   3480

ccataaaata caaacaaaca cattttaaaa tacacattgc ttcaggccaa cgtgactgca   3540

gtttatttat ttgactattt tatggtaggg gagaaggttg agtgttgttg tgaaagccct   3600

gatatcagta atggggatga tacaatctgc cagcagagga gaggttggca ggtaggtcag   3660

ctgcatcact tcacaagaag aatttgaatc ctcactagaa ggggtaccat cctcttccag   3720

ttcatacttc ccatatccaa caacctgaaa gaggacaaag acaaaagtga aaaatatgct   3780

gaccagattt aggggtttaa gagttctgat gataaccacc caaactcact cagtaaatga   3840

caaccctaga atggatggag ttagttaaac atactcacat gaacgctgag cattttactt   3900

cctggccctc tatgggcctt gaaccagttg accaggtctg attttgagaa tgacttcagt   3960

gcttcaatct tacaagggaa gggaagatag gaaagaaatt caagaagaaa gatagctctt   4020

aaacctaacc cccaggcaga tgtccctgga cctgcttagc atctgaagac ctcattttat   4080

tcttcctatt ctcaggttac ccctaacctt ccagaccaaa acgatgatga agctctctgg   4140

catgccttca cattttatac caatcatcta caatggcaag agaggttagc agatgctata   4200

attacagcta aataccatac actgagccca acacccacat ccccttagtg tcacctccca   4260

attacatggt agctgcatac cacggcttga ggaaatctac cttgcttcta ttaagaaaac   4320

taaaatgtgt taagatgaag cctcttacta aataacctct ttacatcaca gagcaatgat   4380

gtcctatggt aattcaccat gtaggggcta tgtattaacc aaagtcacac tggagtacaa   4440

gatccagatc tttttcatag gttttactac tttggaatag aagttgtcaa aacacatgca   4500

cttggaataa tgaactccgt aaagacaaag agtcctcaat tttctttaaa cggcaaaact   4560

ctttttctcc acaaaatctt gtagacctca atatatagca taaaaataga gctgctctga   4620

ttgaaattgg tggtggtgtg gtaaggatta gcacccagct cacgtggcca cctaaggtgc   4680

tagagaggcc agtctgaaaa ctcaggaagt gagcgagtaa tcaggccagg actagtgttt   4740

cgagtttctc ttccacacaa tgctggtgtg cacagacc                           4778


<210>  6366
<211>  571
<212>  PRT
<213>  Homosapiens

<400>  6366

Met Val Glu Ser Ile Lys His Cys Ile Val Leu Leu Gln Ile Ala Lys 
1               5                   10                  15      


Asp Gln Ser Asn Ala Glu Lys His Ala Asp Gly Met Ile Ser Thr Ile 
            20                  25                  30          


Asn Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro Leu Glu Pro Val Ile 
        35                  40                  45              


Ser Thr Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro Val Gln Leu 
    50                  55                  60                  


Cys Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly Pro Val Leu 
65                  70                  75                  80  


Ala Thr Leu Gly His His Gln Thr Pro Thr Pro Asn Ser Thr Gly Ser 
                85                  90                  95      


Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser His Val Asn 
            100                 105                 110         


Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser Ser Glu Asp 
        115                 120                 125             


Glu Phe Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser Ser Pro Lys 
    130                 135                 140                 


Arg Leu Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr His Ser Ser 
145                 150                 155                 160 


Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser Leu Asn Ser 
                165                 170                 175     


Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp Ser His Asp 
            180                 185                 190         


Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu His Lys Ser 
        195                 200                 205             


Val Ile Met His Leu Leu Ser Gln Val Arg Leu Gly Met Asp Leu Thr 
    210                 215                 220                 


Lys Val Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser Leu Leu Glu 
225                 230                 235                 240 


Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val Ser Ile Ser 
                245                 250                 255     


Asp Gln Lys Asp Pro Lys Asp Arg Met Val Gln Val Val Lys Trp Tyr 
            260                 265                 270         


Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala Lys Lys Pro 
        275                 280                 285             


Tyr Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp Thr Leu Pro 
    290                 295                 300                 


Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly Pro Val Pro 
305                 310                 315                 320 


Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln Val Ser His 
                325                 330                 335     


His Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn Lys Lys Ile 
            340                 345                 350         


Gln Phe Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu Gly Met Ser 
        355                 360                 365             


Ile Gly Val His Asn Ile Gly Gln Gly Cys Val Ser Cys Leu Asp Tyr 
    370                 375                 380                 


Asp Glu His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly Arg Ser Ile 
385                 390                 395                 400 


Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn Ile Asn Cys 
                405                 410                 415     


Ser Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr Lys Pro Phe 
            420                 425                 430         


Tyr Gly Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe Ser Pro Asn 
        435                 440                 445             


Asp Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn Gly Val Met 
    450                 455                 460                 


Tyr Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val Asp Thr Lys 
465                 470                 475                 480 


Lys Leu Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu Asp Gln Asn 
                485                 490                 495     


Glu Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe Asn Leu Lys 
            500                 505                 510         


Ile Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg Leu Glu Glu 
        515                 520                 525             


Arg Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu Ile Gln Trp 
    530                 535                 540                 


Glu Thr Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val Tyr Asp Glu 
545                 550                 555                 560 


Pro Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
                565                 570     


<210>  6367
<211>  2837
<212>  DNA
<213>  Homosapiens

<400>  6367
agatggcgtc catcatggaa gggccgctga gcaaatggac taacgtgatg aagggctggc     60

agtaccgttg gttcgtgctg gactacaatg caggactgct ctcctactac acgggagctg    120

tgattggtat agacgatgag gacgacagca ccttcacaat aactgttgat cagaaaacct    180

tccatttcca ggcccgtgat gctgatgagc gagagaagtg gatccatgcc ttagaagaaa    240

caattcttcg acatactctc cagcttcaag gtttggattc aggatttgtt cctagtgtcc    300

aagattttga taagaaactt acagaagctg atgcttacct acaaatcttg attgaacaat    360

taaagctttt tgatgacaag cttcaaaact gcaaagaaga tgaacagaga aagaaaattg    420

aaactctcaa agagacaaca aatagcatgg tagaatcaat taaacactgc attgtgttgc    480

tgcagattgc caaagaccag agtaatgcgg agaagcacgc agatggaatg ataagtacta    540

ttaatcccgt agatgcaata tatcaaccta gtcctttgga acctgtgatc agcacaatgc    600

cttcccagac tgtgttacct ccagaacctg ttcagttgtg taagtcagag cagcgtccat    660

cttccctacc agttggacct gtgttggcta ccttgggaca tcatcagact cctacaccaa    720

atagtacagg cagtggccat tcaccaccga gtagcagtct cacttctcca agccacgtga    780

acttgtctcc aaatacagtc ccagagttct cttactccag cagtgaagat gaattttatg    840

atgctgatga attccatcaa agtggctcat ccccaaagcg cttaatagat tcttctggat    900

ctgcctcagt cctgacacac agcagctcgg gaaatagtct aaaacgccca gataccacag    960

aatcacttaa ttcttccttg tccaatggaa caagtgatgc tgacctgttt gattcacatg   1020

atgacagaga tgatgatgcg gaggcagggt ctgtggagga gcacaagagc gttatcatgc   1080

atctcttgtc gcaggttaga cttggaatgg atcttactaa ggtagttctt ccaacgttta   1140

ttcttgaaag aagatctctt ttagaaatgt atgcagactt ttttgcacat ccggacctgt   1200

ttgtgagcat tagtgaccag aaggatccca aggatcgaat ggttcaggtt gtgaaatggt   1260

acctctcagc ctttcatgcg ggaaggaaag gatcagttgc caaaaagcca tacaatccca   1320

ttttgggcga gatttttcag tgtcattgga cattaccaaa tgatactgaa gagaacacag   1380

aactagtttc agaaggacca gttccctggg tttccaaaaa cagtgtaaca tttgtggctg   1440

agcaggtttc ccatcatcca cccatttcag ccttttatgc tgagtgtttt aacaagaaga   1500

tacaattcaa tgctcatatc tggaccaaat caaaattcct tgggatgtca attggggtgc   1560

acaacatagg gcagggctgt gtctcatgtc tagactatga tgaacattac attctcacat   1620

tccccaatgg ctatggaagg tctatcctca cagtgccctg ggtggaatta ggaggagaat   1680

gcaatattaa ttgttccaaa acaggctata gtgcaaatat catcttccac actaaaccct   1740

tctatggggg caagaagcac agaattactg ccgagatttt ttctccaaat gacaagaagt   1800

ctttttgctc aattgaaggg gaatggaatg gtgtgatgta tgcaaaatat gcaacagggg   1860

aaaatacagt ctttgtagat accaagaagt tgcctataat caagaagaaa gtgaggaagt   1920

tggaagatca gaacgagtat gaatcccgca gcctttggaa ggatgtcact ttcaacttaa   1980

aaatcagaga cattgatgca gcaactgaag caaagcacag gcttgaagaa agacaaagag   2040

cagaagcccg agaaaggaag gagaaggaaa ttcagtggga gacaaggtta tttcatgaag   2100

atggagaatg ctgggtttat gatgaaccat tactgaaacg tcttggtgct gccaagcatt   2160

aggttggaag atgcaaagtt tatacctgat gatcagggca gtaggcataa ttcagcaaca   2220

aacaatcttc ctttgggaga aacctgttca ttccaatctt ctaattacag tggttcctat   2280

ctcagggata ctggactttc tgacgcagat gaacaattaa ggggaaaagc ttcccttttc   2340

cctctgtggc agttacgatt ttgacttcag tcctgagaaa aacttcaggt tttgaaaatc   2400

agatgatgtc ttctcctttt ccaaacacca cacgttgaaa gcatttataa atccaagtct   2460

gaaactctgc gctctagtac tgctgttaag atacacaact tgtttcttag ttcatataat   2520

ctcgggatac acacacacac acacatatat atacacacac atacgtatac acacacatac   2580

atatatataa atatacctga tgccagattt ttttcataaa tattctgcct actgtaaata   2640

tgggttcctc tgagttgttt tagaaaatta gcgcaatgta ttaaaatcaa gtgttaggaa   2700

atttcatggt cttacctaca ataactttta ttttggaatt gaactattat taaattgtat   2760

ctaatcctgg attacagttt aattaattat tcttagtgct taaggcttca taaagtaatt   2820

tttccaacct ttttttt                                                  2837


<210>  6368
<211>  719
<212>  PRT
<213>  Homosapiens

<400>  6368

Met Ala Ser Ile Met Glu Gly Pro Leu Ser Lys Trp Thr Asn Val Met 
1               5                   10                  15      


Lys Gly Trp Gln Tyr Arg Trp Phe Val Leu Asp Tyr Asn Ala Gly Leu 
            20                  25                  30          


Leu Ser Tyr Tyr Thr Gly Ala Val Ile Gly Ile Asp Asp Glu Asp Asp 
        35                  40                  45              


Ser Thr Phe Thr Ile Thr Val Asp Gln Lys Thr Phe His Phe Gln Ala 
    50                  55                  60                  


Arg Asp Ala Asp Glu Arg Glu Lys Trp Ile His Ala Leu Glu Glu Thr 
65                  70                  75                  80  


Ile Leu Arg His Thr Leu Gln Leu Gln Gly Leu Asp Ser Gly Phe Val 
                85                  90                  95      


Pro Ser Val Gln Asp Phe Asp Lys Lys Leu Thr Glu Ala Asp Ala Tyr 
            100                 105                 110         


Leu Gln Ile Leu Ile Glu Gln Leu Lys Leu Phe Asp Asp Lys Leu Gln 
        115                 120                 125             


Asn Cys Lys Glu Asp Glu Gln Arg Lys Lys Ile Glu Thr Leu Lys Glu 
    130                 135                 140                 


Thr Thr Asn Ser Met Val Glu Ser Ile Lys His Cys Ile Val Leu Leu 
145                 150                 155                 160 


Gln Ile Ala Lys Asp Gln Ser Asn Ala Glu Lys His Ala Asp Gly Met 
                165                 170                 175     


Ile Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro Leu 
            180                 185                 190         


Glu Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val Leu Pro Pro Glu 
        195                 200                 205             


Pro Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro Val 
    210                 215                 220                 


Gly Pro Val Leu Ala Thr Leu Gly His His Gln Thr Pro Thr Pro Asn 
225                 230                 235                 240 


Ser Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro 
                245                 250                 255     


Ser His Val Asn Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser 
            260                 265                 270         


Ser Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe His Gln Ser Gly 
        275                 280                 285             


Ser Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser Ala Ser Val Leu 
    290                 295                 300                 


Thr His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu 
305                 310                 315                 320 


Ser Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe 
                325                 330                 335     


Asp Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu 
            340                 345                 350         


Glu His Lys Ser Val Ile Met His Leu Leu Ser Gln Val Arg Leu Gly 
        355                 360                 365             


Met Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile Leu Glu Arg Arg 
    370                 375                 380                 


Ser Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe 
385                 390                 395                 400 


Val Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg Met Val Gln Val 
                405                 410                 415     


Val Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val 
            420                 425                 430         


Ala Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys His 
        435                 440                 445             


Trp Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu 
    450                 455                 460                 


Gly Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu 
465                 470                 475                 480 


Gln Val Ser His His Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe 
                485                 490                 495     


Asn Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr Lys Ser Lys Phe 
            500                 505                 510         


Leu Gly Met Ser Ile Gly Val His Asn Ile Gly Gln Gly Cys Val Ser 
        515                 520                 525             


Cys Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr 
    530                 535                 540                 


Gly Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys 
545                 550                 555                 560 


Asn Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe His 
                565                 570                 575     


Thr Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile Thr Ala Glu Ile 
            580                 585                 590         


Phe Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp 
        595                 600                 605             


Asn Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe 
    610                 615                 620                 


Val Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys Val Arg Lys Leu 
625                 630                 635                 640 


Glu Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val Thr 
                645                 650                 655     


Phe Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys His 
            660                 665                 670         


Arg Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys 
        675                 680                 685             


Glu Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp Gly Glu Cys Trp 
    690                 695                 700                 


Val Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
705                 710                 715                 


<210>  6369
<211>  2772
<212>  DNA
<213>  Homosapiens

<400>  6369
gaagggggtg aagggggtgt cccgggggac gggctgaacc tcagtcagga ccgcctgcac     60

cgcagtccgg ggatcgggtc gaggggagaa gaaaaagggg tgctcgggag cagcccccgg    120

ctacctcccc tggaggcaca gagggcgggg gccttggcga atggctttct tgctggccac    180

ttgcggagtg agtagacccc gagggtctgg gagaggggcc ggcccctacc cctgagtccc    240

cggggtcccg gccgccaggc cggagcgcga atgtcgtgct caccctgcct ccttcccgcc    300

gccccctggg ggtttggatt caggatttgt tcctagtgtc caagattttg ataagaaact    360

tacagaagct gatgcttacc tacaaatctt gattgaacaa ttaaagcttt ttgatgacaa    420

gcttcaaaac tgcaaagaag atgaacagag aaagaaaatt gaaactctca aagagacaac    480

aaatagcatg gtagaatcaa ttaaacactg cattgtgttg ctgcagattg ccaaaagtac    540

tattaatccc gtagatgcaa tatatcaacc tagtcctttg gaacctgtga tcagcacaat    600

gccttcccag actgtgttac ctccagaacc tgttcagttg tgtaagtcag agcagcgtcc    660

atcttcccta ccagttggac ctgtgttggc taccttggga catcatcaga ctcctacacc    720

aaatagtaca ggcagtggcc attcaccacc gagtagcagt ctcacttctc caagccacgt    780

gaacttgtct ccaaatacag tcccagagtt ctcttactcc agcagtgaag atgaatttta    840

tgatgctgat gaattccatc aaagtggctc atccccaaag cgcttaatag attcttctgg    900

atctgcctca gtcctgacac acagcagctc gggaaatagt ctaaaacgcc cagataccac    960

agaatcactt aattcttcct tgtccaatgg aacaagtgat gctgacctgt ttgattcaca   1020

tgatgacaga gatgatgatg cggaggcagg gtctgtggag gagcacaaga gcgttatcat   1080

gcatctcttg tcgcaggtta gacttggaat ggatcttact aaggtagttc ttccaacgtt   1140

tattcttgaa agaagatctc ttttagaaat gtatgcagac ttttttgcac atccggacct   1200

gtttgtgagc attagtgacc agaaggatcc caaggatcga atggttcagg ttgtgaaatg   1260

gtacctctca gcctttcatg cgggaaggaa aggatcagtt gccaaaaagc catacaatcc   1320

cattttgggc gagatttttc agtgtcattg gacattacca aatgatactg aagagaacac   1380

agaactagtt tcagaaggac cagttccctg ggtttccaaa aacagtgtaa catttgtggc   1440

tgagcaggtt tcccatcatc cacccatttc agccttttat gctgagtgtt ttaacaagaa   1500

gatacaattc aatgctcata tctggaccaa atcaaaattc cttgggatgt caattggggt   1560

gcacaacata gggcagggct gtgtctcatg tctagactat gatgaacatt acattctcac   1620

attccccaat ggctatggaa ggtctatcct cacagtgccc tgggtggaat taggaggaga   1680

atgcaatatt aattgttcca aaacaggcta tagtgcaaat atcatcttcc acactaaacc   1740

cttctatggg ggcaagaagc acagaattac tgccgagatt ttttctccaa atgacaagaa   1800

gtctttttgc tcaattgaag gggaatggaa tggtgtgatg tatgcaaaat atgcaacagg   1860

ggaaaataca gtctttgtag ataccaagaa gttgcctata atcaagaaga aagtgaggaa   1920

gttggaagat cagaacgagt atgaatcccg cagcctttgg aaggatgtca ctttcaactt   1980

aaaaatcaga gacattgatg cagcaactga agcaaagcac aggcttgaag aaagacaaag   2040

agcagaagcc cgagaaagga aggagaagga aattcagtgg gagacaaggt tatttcatga   2100

agatggagaa tgctgggttt atgatgaacc attactgaaa cgtcttggtg ctgccaagca   2160

ttaggttgga agatgcaaag tttatacctg atgatcaggg cagtaggcat aattcagcaa   2220

caaacaatct tcctttggga gaaacctgtt cattccaatc ttctaattac agtggttcct   2280

atctcaggga tactggactt tctgacgcag atgaacaatt aaggggaaaa gcttcccttt   2340

tccctctgtg gcagttacga ttttgacttc agtcctgaga aaaacttcag gttttgaaaa   2400

tcagatgatg tcttctcctt ttccaaacac cacacgttga aagcatttat aaatccaagt   2460

ctgaaactct gcgctctagt actgctgtta agatacacaa cttgtttctt agttcatata   2520

atctcgggat acacacacac acacacatat atatacacac acatacgtat acacacacat   2580

acatatatat aaatatacct gatgccagat ttttttcata aatattctgc ctactgtaaa   2640

tatgggttcc tctgagttgt tttagaaaat tagcgcaatg tattaaaatc aagtgttagg   2700

aaatttcatg gtcttaccta caataacttt tattttggaa ttgaactatt attaaattgt   2760

atctaatcct gg                                                       2772


<210>  6370
<211>  558
<212>  PRT
<213>  Homosapiens

<400>  6370

Met Val Glu Ser Ile Lys His Cys Ile Val Leu Leu Gln Ile Ala Lys 
1               5                   10                  15      


Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro Leu Glu 
            20                  25                  30          


Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro 
        35                  40                  45              


Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly 
    50                  55                  60                  


Pro Val Leu Ala Thr Leu Gly His His Gln Thr Pro Thr Pro Asn Ser 
65                  70                  75                  80  


Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser 
                85                  90                  95      


His Val Asn Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser 
            100                 105                 110         


Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser 
        115                 120                 125             


Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr 
    130                 135                 140                 


His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser 
145                 150                 155                 160 


Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp 
                165                 170                 175     


Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu 
            180                 185                 190         


His Lys Ser Val Ile Met His Leu Leu Ser Gln Val Arg Leu Gly Met 
        195                 200                 205             


Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser 
    210                 215                 220                 


Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val 
225                 230                 235                 240 


Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg Met Val Gln Val Val 
                245                 250                 255     


Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala 
            260                 265                 270         


Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp 
        275                 280                 285             


Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly 
    290                 295                 300                 


Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln 
305                 310                 315                 320 


Val Ser His His Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn 
                325                 330                 335     


Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu 
            340                 345                 350         


Gly Met Ser Ile Gly Val His Asn Ile Gly Gln Gly Cys Val Ser Cys 
        355                 360                 365             


Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly 
    370                 375                 380                 


Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn 
385                 390                 395                 400 


Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr 
                405                 410                 415     


Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe 
            420                 425                 430         


Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn 
        435                 440                 445             


Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val 
    450                 455                 460                 


Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu 
465                 470                 475                 480 


Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe 
                485                 490                 495     


Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg 
            500                 505                 510         


Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu 
        515                 520                 525             


Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val 
    530                 535                 540                 


Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
545                 550                 555             


<210>  6371
<211>  2839
<212>  DNA
<213>  Homosapiens

<400>  6371
gaagggggtg aagggggtgt cccgggggac gggctgaacc tcagtcagga ccgcctgcac     60

cgcagtccgg ggatcgggtc gaggggagaa gaaaaagggg tgctcgggag cagcccccgg    120

ctacctcccc tggaggcaca gagggcgggg gccttggcga atggctttct tgctggccac    180

ttgcggagtg agtagacccc gagggtctgg gagaggggcc ggcccctacc cctgagtccc    240

cggggtcccg gccgccaggc cggagcgcga atgtcgtgct caccctgcct ccttcccgcc    300

gccccctggg ggtttggatt caggatttgt tcctagtgtc caagattttg ataagaaact    360

tacagaagct gatgcttacc tacaaatctt gattgaacaa ttaaagcttt ttgatgacaa    420

gcttcaaaac tgcaaagaag atgaacagag aaagaaaatt gaaactctca aagagacaac    480

aaatagcatg gtagaatcaa ttaaacactg cattgtgttg ctgcagattg ccaaaagtac    540

tattaatccc gtagatgcaa tatatcaacc tagtcctttg gaacctgtga tcagcacaat    600

gccttcccag actgtgttac ctccagaacc tgttcagttg tgtaagtcag agcagcgtcc    660

atcttcccta ccagttggac ctgtgttggc taccttggga catcatcaga ctcctacacc    720

aaatagtaca ggcagtggcc attcaccacc gagtagcagt ctcacttctc caagccacgt    780

gaacttgtct ccaaatacag tcccagagtt ctcttactcc agcagtgaag atgaatttta    840

tgatgctgat gaattccatc aaagtggctc atccccaaag cgcttaatag attcttctgg    900

atctgcctca gtcctgacac acagcagctc gggaaatagt ctaaaacgcc cagataccac    960

agaatcactt aattcttcct tgtccaatgg aacaagtgat gctgacctgt ttgattcaca   1020

tgatgacaga gatgatgatg cggaggcagg gtctgtggag gagcacaaga gcgttatcat   1080

gcatctcttg tcgcaggtta gacttggaat ggatcttact aaggtagttc ttccaacgtt   1140

tattcttgaa agaagatctc ttttagaaat gtatgcagac ttttttgcac atccggacct   1200

gtttgtgagc attagtgacc agaaggatcc caaggatcga atggttcagg ttgtgaaatg   1260

gtacctctca gcctttcatg cgggaaggaa aggatcagtt gccaaaaagc catacaatcc   1320

cattttgggc gagatttttc agtgtcattg gacattacca aatgatactg aagagaacac   1380

agaactagtt tcagaaggac cagttccctg ggtttccaaa aacagtgtaa catttgtggc   1440

tgagcaggtt tcccatcatc cacccatttc agccttttat gctgagtgtt ttaacaagaa   1500

gatacaattc aatgctcata tctggaccaa atcaaaattc cttgggatgt caattggggt   1560

gcacaacata gggcagggct gtgtctcatg tctagactat gatgaacatt acattctcac   1620

attccccaat ggctatggaa ggtctatcct cacagtgccc tgggtggaat taggaggaga   1680

atgcaatatt aattgttcca aaacaggcta tagtgcaaat atcatcttcc acactaaacc   1740

cttctatggg ggcaagaagc acagaattac tgccgagatt ttttctccaa atgacaagaa   1800

gtctttttgc tcaattgaag gggaatggaa tggtgtgatg tatgcaaaat atgcaacagg   1860

ggaaaataca gtctttgtag ataccaagaa gttgcctata atcaagaaga aagtgaggaa   1920

gttggaagat cagaacgagt atgaatcccg cagcctttgg aaggatgtca ctttcaactt   1980

aaaaatcaga gacattgatg cagcaactga agcaaagcac aggcttgaag aaagacaaag   2040

agcagaagcc cgagaaagga aggagaagga aattcagtgg gagacaaggt tatttcatga   2100

agatggagaa tgctgggttt atgatgaacc attactgaaa cgtcttggtg ctgccaagca   2160

ttaggttgga agatgcaaag tttatacctg atgatcaggg cagtaggcat aattcagcaa   2220

caaacaatct tcctttggga gaaacctgtt cattccaatc ttctaattac agtggttcct   2280

atctcaggga tactggactt tctgacgcag atgaacaatt aaggggaaaa gcttcccttt   2340

tccctctgtg gcagttacga ttttgacttc agtcctgaga aaaacttcag gttttgaaaa   2400

tcagatgatg tcttctcctt ttccaaacac cacacgttga aagcatttat aaatccaagt   2460

ctgaaactct gcgctctagt actgctgtta agatacacaa cttgtttctt agttcatata   2520

atctcgggat acacacacac acacacatat atatacacac acatacgtat acacacacat   2580

acatatatat aaatatacct gatgccagat ttttttcata aatattctgc ctactgtaaa   2640

tatgggttcc tctgagttgt tttagaaaat tagcgcaatg tattaaaatc aagtgttagg   2700

aaatttcatg gtcttaccta caataacttt tattttggaa ttgaactatt attaaattgt   2760

atctaatcct ggattacagt ttaattaatt attcttagtg cttaaggctt cataaagtaa   2820

tttttccaac ctttttttt                                                2839


<210>  6372
<211>  558
<212>  PRT
<213>  Homosapiens

<400>  6372

Met Val Glu Ser Ile Lys His Cys Ile Val Leu Leu Gln Ile Ala Lys 
1               5                   10                  15      


Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro Leu Glu 
            20                  25                  30          


Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro 
        35                  40                  45              


Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly 
    50                  55                  60                  


Pro Val Leu Ala Thr Leu Gly His His Gln Thr Pro Thr Pro Asn Ser 
65                  70                  75                  80  


Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser 
                85                  90                  95      


His Val Asn Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser 
            100                 105                 110         


Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser 
        115                 120                 125             


Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr 
    130                 135                 140                 


His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser 
145                 150                 155                 160 


Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp 
                165                 170                 175     


Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu 
            180                 185                 190         


His Lys Ser Val Ile Met His Leu Leu Ser Gln Val Arg Leu Gly Met 
        195                 200                 205             


Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser 
    210                 215                 220                 


Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val 
225                 230                 235                 240 


Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg Met Val Gln Val Val 
                245                 250                 255     


Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala 
            260                 265                 270         


Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp 
        275                 280                 285             


Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly 
    290                 295                 300                 


Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln 
305                 310                 315                 320 


Val Ser His His Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn 
                325                 330                 335     


Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu 
            340                 345                 350         


Gly Met Ser Ile Gly Val His Asn Ile Gly Gln Gly Cys Val Ser Cys 
        355                 360                 365             


Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly 
    370                 375                 380                 


Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn 
385                 390                 395                 400 


Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr 
                405                 410                 415     


Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe 
            420                 425                 430         


Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn 
        435                 440                 445             


Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val 
    450                 455                 460                 


Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu 
465                 470                 475                 480 


Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe 
                485                 490                 495     


Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg 
            500                 505                 510         


Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu 
        515                 520                 525             


Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val 
    530                 535                 540                 


Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
545                 550                 555             


<210>  6373
<211>  2743
<212>  DNA
<213>  Homosapiens

<400>  6373
gaagggggtg aagggggtgt cccgggggac gggctgaacc tcagtcagga ccgcctgcac     60

cgcagtccgg ggatcgggtc gaggggagaa gaaaaagggg tgctcgggag cagcccccgg    120

ctacctcccc tggaggcaca gagggcgggg gccttggcga atggctttct tgctggccac    180

ttgcggagtg agtagacccc gagggtctgg gagaggggcc ggcccctacc cctgagtccc    240

cggggtcccg gccgccaggc cggagcgcga atgtcgtgct caccctgcct ccttcccgcc    300

gccccctggg ctttttgatg acaagcttca aaactgcaaa gaagatgaac agagaaagaa    360

aattgaaact ctcaaagaga caacaaatag catggtagaa tcaattaaac actgcattgt    420

gttgctgcag attgccaaaa gtactattaa tcccgtagat gcaatatatc aacctagtcc    480

tttggaacct gtgatcagca caatgccttc ccagactgtg ttacctccag aacctgttca    540

gttgtgtaag tcagagcagc gtccatcttc cctaccagtt ggacctgtgt tggctacctt    600

gggacatcat cagactccta caccaaatag tacaggcagt ggccattcac caccgagtag    660

cagtctcact tctccaagcc acgtgaactt gtctccaaat acagtcccag agttctctta    720

ctccagcagt gaagatgaat tttatgatgc tgatgaattc catcaaagtg gctcatcccc    780

aaagcgctta atagattctt ctggatctgc ctcagtcctg acacacagca gctcgggaaa    840

tagtctaaaa cgcccagata ccacagaatc acttaattct tccttgtcca atggaacaag    900

tgatgctgac ctgtttgatt cacatgatga cagagatgat gatgcggagg cagggtctgt    960

ggaggagcac aagagcgtta tcatgcatct cttgtcgcag gttagacttg gaatggatct   1020

tactaaggta gttcttccaa cgtttattct tgaaagaaga tctcttttag aaatgtatgc   1080

agactttttt gcacatccgg acctgtttgt gagcattagt gaccagaagg atcccaagga   1140

tcgaatggtt caggttgtga aatggtacct ctcagccttt catgcgggaa ggaaaggatc   1200

agttgccaaa aagccataca atcccatttt gggcgagatt tttcagtgtc attggacatt   1260

accaaatgat actgaagaga acacagaact agtttcagaa ggaccagttc cctgggtttc   1320

caaaaacagt gtaacatttg tggctgagca ggtttcccat catccaccca tttcagcctt   1380

ttatgctgag tgttttaaca agaagataca attcaatgct catatctgga ccaaatcaaa   1440

attccttggg atgtcaattg gggtgcacaa catagggcag ggctgtgtct catgtctaga   1500

ctatgatgaa cattacattc tcacattccc caatggctat ggaaggtcta tcctcacagt   1560

gccctgggtg gaattaggag gagaatgcaa tattaattgt tccaaaacag gctatagtgc   1620

aaatatcatc ttccacacta aacccttcta tgggggcaag aagcacagaa ttactgccga   1680

gattttttct ccaaatgaca agaagtcttt ttgctcaatt gaaggggaat ggaatggtgt   1740

gatgtatgca aaatatgcaa caggggaaaa tacagtcttt gtagatacca agaagttgcc   1800

tataatcaag aagaaagtga ggaagttgga agatcagaac gagtatgaat cccgcagcct   1860

ttggaaggat gtcactttca acttaaaaat cagagacatt gatgcagcaa ctgaagcaaa   1920

gcacaggctt gaagaaagac aaagagcaga agcccgagaa aggaaggaga aggaaattca   1980

gtgggagaca aggttatttc atgaagatgg agaatgctgg gtttatgatg aaccattact   2040

gaaacgtctt ggtgctgcca agcattaggt tggaagatgc aaagtttata cctgatgatc   2100

agggcagtag gcataattca gcaacaaaca atcttccttt gggagaaacc tgttcattcc   2160

aatcttctaa ttacagtggt tcctatctca gggatactgg actttctgac gcagatgaac   2220

aattaagggg aaaagcttcc cttttccctc tgtggcagtt acgattttga cttcagtcct   2280

gagaaaaact tcaggttttg aaaatcagat gatgtcttct ccttttccaa acaccacacg   2340

ttgaaagcat ttataaatcc aagtctgaaa ctctgcgctc tagtactgct gttaagatac   2400

acaacttgtt tcttagttca tataatctcg ggatacacac acacacacac atatatatac   2460

acacacatac gtatacacac acatacatat atataaatat acctgatgcc agattttttt   2520

cataaatatt ctgcctactg taaatatggg ttcctctgag ttgttttaga aaattagcgc   2580

aatgtattaa aatcaagtgt taggaaattt catggtctta cctacaataa cttttatttt   2640

ggaattgaac tattattaaa ttgtatctaa tcctggatta cagtttaatt aattattctt   2700

agtgcttaag gcttcataaa gtaatttttc caaccttttt ttt                     2743


<210>  6374
<211>  558
<212>  PRT
<213>  Homosapiens

<400>  6374

Met Val Glu Ser Ile Lys His Cys Ile Val Leu Leu Gln Ile Ala Lys 
1               5                   10                  15      


Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro Leu Glu 
            20                  25                  30          


Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro 
        35                  40                  45              


Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly 
    50                  55                  60                  


Pro Val Leu Ala Thr Leu Gly His His Gln Thr Pro Thr Pro Asn Ser 
65                  70                  75                  80  


Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser 
                85                  90                  95      


His Val Asn Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser 
            100                 105                 110         


Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser 
        115                 120                 125             


Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr 
    130                 135                 140                 


His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser 
145                 150                 155                 160 


Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp 
                165                 170                 175     


Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu 
            180                 185                 190         


His Lys Ser Val Ile Met His Leu Leu Ser Gln Val Arg Leu Gly Met 
        195                 200                 205             


Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser 
    210                 215                 220                 


Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val 
225                 230                 235                 240 


Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg Met Val Gln Val Val 
                245                 250                 255     


Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala 
            260                 265                 270         


Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp 
        275                 280                 285             


Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly 
    290                 295                 300                 


Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln 
305                 310                 315                 320 


Val Ser His His Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn 
                325                 330                 335     


Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu 
            340                 345                 350         


Gly Met Ser Ile Gly Val His Asn Ile Gly Gln Gly Cys Val Ser Cys 
        355                 360                 365             


Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly 
    370                 375                 380                 


Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn 
385                 390                 395                 400 


Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr 
                405                 410                 415     


Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe 
            420                 425                 430         


Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn 
        435                 440                 445             


Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val 
    450                 455                 460                 


Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu 
465                 470                 475                 480 


Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe 
                485                 490                 495     


Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg 
            500                 505                 510         


Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu 
        515                 520                 525             


Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val 
    530                 535                 540                 


Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
545                 550                 555             


<210>  6375
<211>  2681
<212>  DNA
<213>  Homosapiens

<400>  6375
gaacctcagt caggaccgcc tgcaccgcag tccggggatc gggtcgaggg gagaagaaaa     60

aggggtgctc gggagcagcc cccggctacc tcccctggag gcacagaggg cgggggcctt    120

ggcgaatggc tttcttgctg gccacttgcg gaggtttgga ttcaggattt gttcctagtg    180

tccaagattt tgataagaaa cttacagaag ctgatgctta cctacaaatc ttgattgaac    240

aattaaagct ttttgatgac aagcttcaaa actgcaaaga agatgaacag agaaagaaaa    300

ttgaaactct caaagagaca acaaatagca tggtagaatc aattaaacac tgcattgtgt    360

tgctgcagat tgccaaaagt actattaatc ccgtagatgc aatatatcaa cctagtcctt    420

tggaacctgt gatcagcaca atgccttccc agactgtgtt acctccagaa cctgttcagt    480

tgtgtaagtc agagcagcgt ccatcttccc taccagttgg acctgtgttg gctaccttgg    540

gacatcatca gactcctaca ccaaatagta caggcagtgg ccattcacca ccgagtagca    600

gtctcacttc tccaagccac gtgaacttgt ctccaaatac agtcccagag ttctcttact    660

ccagcagtga agatgaattt tatgatgctg atgaattcca tcaaagtggc tcatccccaa    720

agcgcttaat agattcttct ggatctgcct cagtcctgac acacagcagc tcgggaaata    780

gtctaaaacg cccagatacc acagaatcac ttaattcttc cttgtccaat ggaacaagtg    840

atgctgacct gtttgattca catgatgaca gagatgatga tgcggaggca gggtctgtgg    900

aggagcacaa gagcgttatc atgcatctct tgtcgcaggt tagacttgga atggatctta    960

ctaaggtagt tcttccaacg tttattcttg aaagaagatc tcttttagaa atgtatgcag   1020

acttttttgc acatccggac ctgtttgtga gcattagtga ccagaaggat cccaaggatc   1080

gaatggttca ggttgtgaaa tggtacctct cagcctttca tgcgggaagg aaaggatcag   1140

ttgccaaaaa gccatacaat cccattttgg gcgagatttt tcagtgtcat tggacattac   1200

caaatgatac tgaagagaac acagaactag tttcagaagg accagttccc tgggtttcca   1260

aaaacagtgt aacatttgtg gctgagcagg tttcccatca tccacccatt tcagcctttt   1320

atgctgagtg ttttaacaag aagatacaat tcaatgctca tatctggacc aaatcaaaat   1380

tccttgggat gtcaattggg gtgcacaaca tagggcaggg ctgtgtctca tgtctagact   1440

atgatgaaca ttacattctc acattcccca atggctatgg aaggtctatc ctcacagtgc   1500

cctgggtgga attaggagga gaatgcaata ttaattgttc caaaacaggc tatagtgcaa   1560

atatcatctt ccacactaaa cccttctatg ggggcaagaa gcacagaatt actgccgaga   1620

ttttttctcc aaatgacaag aagtcttttt gctcaattga aggggaatgg aatggtgtga   1680

tgtatgcaaa atatgcaaca ggggaaaata cagtctttgt agataccaag aagttgccta   1740

taatcaagaa gaaagtgagg aagttggaag atcagaacga gtatgaatcc cgcagccttt   1800

ggaaggatgt cactttcaac ttaaaaatca gagacattga tgcagcaact gaagcaaagc   1860

acaggcttga agaaagacaa agagcagaag cccgagaaag gaaggagaag gaaattcagt   1920

gggagacaag gttatttcat gaagatggag aatgctgggt ttatgatgaa ccattactga   1980

aacgtcttgg tgctgccaag cattaggttg gaagatgcaa agtttatacc tgatgatcag   2040

ggcagtaggc ataattcagc aacaaacaat cttcctttgg gagaaacctg ttcattccaa   2100

tcttctaatt acagtggttc ctatctcagg gatactggac tttctgacgc agatgaacaa   2160

ttaaggggaa aagcttccct tttccctctg tggcagttac gattttgact tcagtcctga   2220

gaaaaacttc aggttttgaa aatcagatga tgtcttctcc ttttccaaac accacacgtt   2280

gaaagcattt ataaatccaa gtctgaaact ctgcgctcta gtactgctgt taagatacac   2340

aacttgtttc ttagttcata taatctcggg atacacacac acacacacat atatatacac   2400

acacatacgt atacacacac atacatatat ataaatatac ctgatgccag atttttttca   2460

taaatattct gcctactgta aatatgggtt cctctgagtt gttttagaaa attagcgcaa   2520

tgtattaaaa tcaagtgtta ggaaatttca tggtcttacc tacaataact tttattttgg   2580

aattgaacta ttattaaatt gtatctaatc ctggattaca gtttaattaa ttattcttag   2640

tgcttaaggc ttcataaagt aatttttcca accttttttt t                       2681


<210>  6376
<211>  626
<212>  PRT
<213>  Homosapiens

<400>  6376

Met Ala Phe Leu Leu Ala Thr Cys Gly Gly Leu Asp Ser Gly Phe Val 
1               5                   10                  15      


Pro Ser Val Gln Asp Phe Asp Lys Lys Leu Thr Glu Ala Asp Ala Tyr 
            20                  25                  30          


Leu Gln Ile Leu Ile Glu Gln Leu Lys Leu Phe Asp Asp Lys Leu Gln 
        35                  40                  45              


Asn Cys Lys Glu Asp Glu Gln Arg Lys Lys Ile Glu Thr Leu Lys Glu 
    50                  55                  60                  


Thr Thr Asn Ser Met Val Glu Ser Ile Lys His Cys Ile Val Leu Leu 
65                  70                  75                  80  


Gln Ile Ala Lys Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln Pro 
                85                  90                  95      


Ser Pro Leu Glu Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val Leu 
            100                 105                 110         


Pro Pro Glu Pro Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser Ser 
        115                 120                 125             


Leu Pro Val Gly Pro Val Leu Ala Thr Leu Gly His His Gln Thr Pro 
    130                 135                 140                 


Thr Pro Asn Ser Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser Leu 
145                 150                 155                 160 


Thr Ser Pro Ser His Val Asn Leu Ser Pro Asn Thr Val Pro Glu Phe 
                165                 170                 175     


Ser Tyr Ser Ser Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe His 
            180                 185                 190         


Gln Ser Gly Ser Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser Ala 
        195                 200                 205             


Ser Val Leu Thr His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro Asp 
    210                 215                 220                 


Thr Thr Glu Ser Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp Ala 
225                 230                 235                 240 


Asp Leu Phe Asp Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala Gly 
                245                 250                 255     


Ser Val Glu Glu His Lys Ser Val Ile Met His Leu Leu Ser Gln Val 
            260                 265                 270         


Arg Leu Gly Met Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile Leu 
        275                 280                 285             


Glu Arg Arg Ser Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His Pro 
    290                 295                 300                 


Asp Leu Phe Val Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg Met 
305                 310                 315                 320 


Val Gln Val Val Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg Lys 
                325                 330                 335     


Gly Ser Val Ala Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile Phe 
            340                 345                 350         


Gln Cys His Trp Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu Leu 
        355                 360                 365             


Val Ser Glu Gly Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr Phe 
    370                 375                 380                 


Val Ala Glu Gln Val Ser His His Pro Pro Ile Ser Ala Phe Tyr Ala 
385                 390                 395                 400 


Glu Cys Phe Asn Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr Lys 
                405                 410                 415     


Ser Lys Phe Leu Gly Met Ser Ile Gly Val His Asn Ile Gly Gln Gly 
            420                 425                 430         


Cys Val Ser Cys Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe Pro 
        435                 440                 445             


Asn Gly Tyr Gly Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu Gly 
    450                 455                 460                 


Gly Glu Cys Asn Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn Ile 
465                 470                 475                 480 


Ile Phe His Thr Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile Thr 
                485                 490                 495     


Ala Glu Ile Phe Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile Glu 
            500                 505                 510         


Gly Glu Trp Asn Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu Asn 
        515                 520                 525             


Thr Val Phe Val Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys Val 
    530                 535                 540                 


Arg Lys Leu Glu Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp Lys 
545                 550                 555                 560 


Asp Val Thr Phe Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr Glu 
                565                 570                 575     


Ala Lys His Arg Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu Arg 
            580                 585                 590         


Lys Glu Lys Glu Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp Gly 
        595                 600                 605             


Glu Cys Trp Val Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala Ala 
    610                 615                 620                 


Lys His 
625     


<210>  6377
<211>  4684
<212>  DNA
<213>  Homosapiens

<400>  6377
gaacctcagt caggaccgcc tgcaccgcag tccggggatc gggtcgaggg gagaagaaaa     60

aggggtgctc gggagcagcc cccggctacc tcccctggag gcacagaggg cgggggcctt    120

ggcgaatggc tttcttgctg gccacttgcg gaggtttgga ttcaggattt gttcctagtg    180

tccaagattt tgataagaaa cttacagaag ctgatgctta cctacaaatc ttgattgaac    240

aattaaagct ttttgatgac aagcttcaaa actgcaaaga agatgaacag agaaagaaaa    300

ttgaaactct caaagagaca acaaatagca tggtagaatc aattaaacac tgcattgtgt    360

tgctgcagat tgccaaaagt actattaatc ccgtagatgc aatatatcaa cctagtcctt    420

tggaacctgt gatcagcaca atgccttccc agactgtgtt acctccagaa cctgttcagt    480

tgtgtaagtc agagcagcgt ccatcttccc taccagttgg acctgtgttg gctaccttgg    540

gacatcatca gactcctaca ccaaatagta caggcagtgg ccattcacca ccgagtagca    600

gtctcacttc tccaagccac gtgaacttgt ctccaaatac agtcccagag ttctcttact    660

ccagcagtga agatgaattt tatgatgctg atgaattcca tcaaagtggc tcatccccaa    720

agcgcttaat agattcttct ggatctgcct cagtcctgac acacagcagc tcgggaaata    780

gtctaaaacg cccagatacc acagaatcac ttaattcttc cttgtccaat ggaacaagtg    840

atgctgacct gtttgattca catgatgaca gagatgatga tgcggaggca gggtctgtgg    900

aggagcacaa gagcgttatc atgcatctct tgtcgcaggt tagacttgga atggatctta    960

ctaaggtagt tcttccaacg tttattcttg aaagaagatc tcttttagaa atgtatgcag   1020

acttttttgc acatccggac ctgtttgtga gcattagtga ccagaaggat cccaaggatc   1080

gaatggttca ggttgtgaaa tggtacctct cagcctttca tgcgggaagg aaaggatcag   1140

ttgccaaaaa gccatacaat cccattttgg gcgagatttt tcagtgtcat tggacattac   1200

caaatgatac tgaagagaac acagaactag tttcagaagg accagttccc tgggtttcca   1260

aaaacagtgt aacatttgtg gctgagcagg tttcccatca tccacccatt tcagcctttt   1320

atgctgagtg ttttaacaag aagatacaat tcaatgctca tatctggacc aaatcaaaat   1380

tccttgggat gtcaattggg gtgcacaaca tagggcaggg ctgtgtctca tgtctagact   1440

atgatgaaca ttacattctc acattcccca atggctatgg aaggtctatc ctcacagtgc   1500

cctgggtgga attaggagga gaatgcaata ttaattgttc caaaacaggc tatagtgcaa   1560

atatcatctt ccacactaaa cccttctatg ggggcaagaa gcacagaatt actgccgaga   1620

ttttttctcc aaatgacaag aagtcttttt gctcaattga aggggaatgg aatggtgtga   1680

tgtatgcaaa atatgcaaca ggggaaaata cagtctttgt agataccaag aagttgccta   1740

taatcaagaa gaaagtgagg aagttggaag atcagaacga gtatgaatcc cgcagccttt   1800

ggaaggatgt cactttcaac ttaaaaatca gagacattga tgcagcaact gaagcaaagc   1860

acaggcttga agaaagacaa agagcagaag cccgagaaag gaaggagaag gaaattcagt   1920

gggagacaag gttatttcat gaagatggag aatgctgggt ttatgatgaa ccattactga   1980

aacgtcttgg tgctgccaag cattaggttg gaagatgcaa agtttatacc tgatgatcag   2040

ggcagtaggc ataattcagc aacaaacaat cttcctttgg gagaaacctg ttcattccaa   2100

tcttctaatt acagtggttc ctatctcagg gatactggac tttctgacgc agatgaacaa   2160

ttaaggggaa aagcttccct tttccctctg tggcagttac gattttgact tcagtcctga   2220

gaaaaacttc aggttttgaa aatcagatga tgtcttctcc ttttccaaac accacacgtt   2280

gaaagcattt ataaatccaa gtctgaaact ctgcgctcta gtactgctgt taagatacac   2340

aacttgtttc ttagttcata taatctcggg atacacacac acacacacat atatatacac   2400

acacatacgt atacacacac atacatatat ataaatatac ctgatgccag atttttttca   2460

taaatattct gcctactgta aatatgggtt cctctgagtt gttttagaaa attagcgcaa   2520

tgtattaaaa tcaagtgtta ggaaatttca tggtcttacc tacaataact tttattttgg   2580

aattgaacta ttattaaatt gtatctaatc ctggattaca gtttaattaa ttattcttag   2640

tgcttaaggc ttcataaagt aatttttcca accttttttt taaaaatgtg catcttttat   2700

tatcttttat ggttaaactt ggaagccaat tatttggcaa ccttgaatac aagagctagc   2760

ttttcaaaga aagacacttg aaataatgga ggatccattc ttttcctctg tcagattgta   2820

tgttctgtct ttagcccctg ccaggcaatt ccccagaatc ttcacttaac tcatattgca   2880

catgtagggc tgcctaccaa cattttatcc aaaaatgttt tattgcctta gagggtttgg   2940

gaagagtgtg tatttataga tccccacccc acagtgaaca aaaatagata gatagataga   3000

ataaaatgaa tgccacagca gcagatggct cattctgaag ggaaatacag aactatatct   3060

atctatctat ctatcatctt ttttatttaa aaatacatta aaaaaacagg tattagtacc   3120

tagcatttag ttagttattc aatatactgg ttacgtaagg cctttcaaga agtagattct   3180

cagtctgaga ggacacaggc cagggcttct caaagtgctg ctgcaggctt tctggtctcg   3240

cttggcccat tctgctaatt ttcctttgcc agctcctaca gtaaccctgg gtttattagt   3300

ctcaacaaag gataaaaagt aaatcaaatg ctatgatgcc agtgcaaaac ttcaatggaa   3360

gccctaaggc agtagtataa ctaactccat aaaatacaaa caaacacatt ttaaaataca   3420

cattgcttca ggccaacgtg actgcagttt atttatttga ctattttatg gtaggggaga   3480

aggttgagtg ttgttgtgaa agccctgata tcagtaatgg ggatgataca atctgccagc   3540

agaggagagg ttggcaggta ggtcagctgc atcacttcac aagaagaatt tgaatcctca   3600

ctagaagggg taccatcctc ttccagttca tacttcccat atccaacaac ctgaaagagg   3660

acaaagacaa aagtgaaaaa tatgctgacc agatttaggg gtttaagagt tctgatgata   3720

accacccaaa ctcactcagt aaatgacaac cctagaatgg atggagttag ttaaacatac   3780

tcacatgaac gctgagcatt ttacttcctg gccctctatg ggccttgaac cagttgacca   3840

ggtctgattt tgagaatgac ttcagtgctt caatcttaca agggaaggga agataggaaa   3900

gaaattcaag aagaaagata gctcttaaac ctaaccccca ggcagatgtc cctggacctg   3960

cttagcatct gaagacctca ttttattctt cctattctca ggttacccct aaccttccag   4020

accaaaacga tgatgaagct ctctggcatg ccttcacatt ttataccaat catctacaat   4080

ggcaagagag gttagcagat gctataatta cagctaaata ccatacactg agcccaacac   4140

ccacatcccc ttagtgtcac ctcccaatta catggtagct gcataccacg gcttgaggaa   4200

atctaccttg cttctattaa gaaaactaaa atgtgttaag atgaagcctc ttactaaata   4260

acctctttac atcacagagc aatgatgtcc tatggtaatt caccatgtag gggctatgta   4320

ttaaccaaag tcacactgga gtacaagatc cagatctttt tcataggttt tactactttg   4380

gaatagaagt tgtcaaaaca catgcacttg gaataatgaa ctccgtaaag acaaagagtc   4440

ctcaattttc tttaaacggc aaaactcttt ttctccacaa aatcttgtag acctcaatat   4500

atagcataaa aatagagctg ctctgattga aattggtggt ggtgtggtaa ggattagcac   4560

ccagctcacg tggccaccta aggtgctaga gaggccagtc tgaaaactca ggaagtgagc   4620

gagtaatcag gccaggacta gtgtttcgag tttctcttcc acacaatgct ggtgtgcaca   4680

gacc                                                                4684


<210>  6378
<211>  626
<212>  PRT
<213>  Homosapiens

<400>  6378

Met Ala Phe Leu Leu Ala Thr Cys Gly Gly Leu Asp Ser Gly Phe Val 
1               5                   10                  15      


Pro Ser Val Gln Asp Phe Asp Lys Lys Leu Thr Glu Ala Asp Ala Tyr 
            20                  25                  30          


Leu Gln Ile Leu Ile Glu Gln Leu Lys Leu Phe Asp Asp Lys Leu Gln 
        35                  40                  45              


Asn Cys Lys Glu Asp Glu Gln Arg Lys Lys Ile Glu Thr Leu Lys Glu 
    50                  55                  60                  


Thr Thr Asn Ser Met Val Glu Ser Ile Lys His Cys Ile Val Leu Leu 
65                  70                  75                  80  


Gln Ile Ala Lys Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln Pro 
                85                  90                  95      


Ser Pro Leu Glu Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val Leu 
            100                 105                 110         


Pro Pro Glu Pro Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser Ser 
        115                 120                 125             


Leu Pro Val Gly Pro Val Leu Ala Thr Leu Gly His His Gln Thr Pro 
    130                 135                 140                 


Thr Pro Asn Ser Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser Leu 
145                 150                 155                 160 


Thr Ser Pro Ser His Val Asn Leu Ser Pro Asn Thr Val Pro Glu Phe 
                165                 170                 175     


Ser Tyr Ser Ser Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe His 
            180                 185                 190         


Gln Ser Gly Ser Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser Ala 
        195                 200                 205             


Ser Val Leu Thr His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro Asp 
    210                 215                 220                 


Thr Thr Glu Ser Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp Ala 
225                 230                 235                 240 


Asp Leu Phe Asp Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala Gly 
                245                 250                 255     


Ser Val Glu Glu His Lys Ser Val Ile Met His Leu Leu Ser Gln Val 
            260                 265                 270         


Arg Leu Gly Met Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile Leu 
        275                 280                 285             


Glu Arg Arg Ser Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His Pro 
    290                 295                 300                 


Asp Leu Phe Val Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg Met 
305                 310                 315                 320 


Val Gln Val Val Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg Lys 
                325                 330                 335     


Gly Ser Val Ala Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile Phe 
            340                 345                 350         


Gln Cys His Trp Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu Leu 
        355                 360                 365             


Val Ser Glu Gly Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr Phe 
    370                 375                 380                 


Val Ala Glu Gln Val Ser His His Pro Pro Ile Ser Ala Phe Tyr Ala 
385                 390                 395                 400 


Glu Cys Phe Asn Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr Lys 
                405                 410                 415     


Ser Lys Phe Leu Gly Met Ser Ile Gly Val His Asn Ile Gly Gln Gly 
            420                 425                 430         


Cys Val Ser Cys Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe Pro 
        435                 440                 445             


Asn Gly Tyr Gly Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu Gly 
    450                 455                 460                 


Gly Glu Cys Asn Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn Ile 
465                 470                 475                 480 


Ile Phe His Thr Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile Thr 
                485                 490                 495     


Ala Glu Ile Phe Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile Glu 
            500                 505                 510         


Gly Glu Trp Asn Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu Asn 
        515                 520                 525             


Thr Val Phe Val Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys Val 
    530                 535                 540                 


Arg Lys Leu Glu Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp Lys 
545                 550                 555                 560 


Asp Val Thr Phe Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr Glu 
                565                 570                 575     


Ala Lys His Arg Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu Arg 
            580                 585                 590         


Lys Glu Lys Glu Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp Gly 
        595                 600                 605             


Glu Cys Trp Val Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala Ala 
    610                 615                 620                 


Lys His 
625     


<210>  6379
<211>  3370
<212>  DNA
<213>  Homosapiens

<400>  6379
cttctaaatg gtaaatgtaa actttgctgt ggcaaagact ttggtttaac atgtacacac     60

tcgcaccccc ctgctgccct atggagtttt ctttttaaaa tgccttcatg ctgtcagaat    120

aatttcttga cttagaatca gagaatccta gacttttctc ccctctaaaa ttaactacat    180

gtctgaattt ttctccctct cttctgaatc ctcagaaagc aagccctctt ctctacactc    240

cccagttaga agatgcatct ctttctcttt agtgaccata aaactagaca cacagtcagc    300

cttctgcatc tgtggattca accaaccatg gattcaaaat atttgaggaa aaaaaaagta    360

cctctttact gaatatgtat atactgtttt ccttgtcatg atttcctaaa caatacagta    420

taatggtgat ttatataata tttacataat attaggtgtc ataagtaatt tagagatgat    480

ttaacttata tgggagcgta tgtgtaggtt gtatgcaaat actacacgat attttatcag    540

ggacttgagt gtctgtggat tttggcatcc tcggggggtg cttggaacca gtccccctgg    600

atacctgagg agtgactgta ctgtgtgata gcagcagtat gggatggaaa gatgagatcc    660

tagtggtgca ggtacatcag ttggacattt ggtgtaactc accaaaagtg aaaaaaacag    720

agaaacaata tttgtggtga attaagagat tgagaagcac cgaattgaat tgagaggtgg    780

ttttgacttc ctgaaatctc cccacaccat tttataactc ctcagttttt ccatttagct    840

ttaccttctt ctgtgacaga gattcattca ttgtctttcc ttactatgct ttaagcaact    900

cttacacttc tgtatagaaa aggtgtttca ttccctcttt tcattttgat caacatatct    960

atatagctac cctcaggatt ttgaagtcat aaatgtgggc atttgggagg gtagcatgag   1020

aagagcattt aattaaaaat agctatattg tgtttcttta ttttagagta ctattaatcc   1080

cgtagatgca atatatcaac ctagtccttt ggaacctgtg atcagcacaa tgccttccca   1140

gactgtgtta cctccagaac ctgttcagtt gtgtaagtca gagcagcgtc catcttccct   1200

accagttgga cctgtgttgg ctaccttggg acatcatcag actcctacac caaatagtac   1260

aggcagtggc cattcaccac cgagtagcag tctcacttct ccaagccacg tgaacttgtc   1320

tccaaataca gtcccagagt tctcttactc cagcagtgaa gatgaatttt atgatgctga   1380

tgaattccat caaagtggct catccccaaa gcgcttaata gattcttctg gatctgcctc   1440

agtcctgaca cacagcagct cgggaaatag tctaaaacgc ccagatacca cagaatcact   1500

taattcttcc ttgtccaatg gaacaagtga tgctgacctg tttgattcac atgatgacag   1560

agatgatgat gcggaggcag ggtctgtgga ggagcacaag agcgttatca tgcatctctt   1620

gtcgcaggtt agacttggaa tggatcttac taaggtagtt cttccaacgt ttattcttga   1680

aagaagatct cttttagaaa tgtatgcaga cttttttgca catccggacc tgtttgtgag   1740

cattagtgac cagaaggatc ccaaggatcg aatggttcag gttgtgaaat ggtacctctc   1800

agcctttcat gcgggaagga aaggatcagt tgccaaaaag ccatacaatc ccattttggg   1860

cgagattttt cagtgtcatt ggacattacc aaatgatact gaagagaaca cagaactagt   1920

ttcagaagga ccagttccct gggtttccaa aaacagtgta acatttgtgg ctgagcaggt   1980

ttcccatcat ccacccattt cagcctttta tgctgagtgt tttaacaaga agatacaatt   2040

caatgctcat atctggacca aatcaaaatt ccttgggatg tcaattgggg tgcacaacat   2100

agggcagggc tgtgtctcat gtctagacta tgatgaacat tacattctca cattccccaa   2160

tggctatgga aggtctatcc tcacagtgcc ctgggtggaa ttaggaggag aatgcaatat   2220

taattgttcc aaaacaggct atagtgcaaa tatcatcttc cacactaaac ccttctatgg   2280

gggcaagaag cacagaatta ctgccgagat tttttctcca aatgacaaga agtctttttg   2340

ctcaattgaa ggggaatgga atggtgtgat gtatgcaaaa tatgcaacag gggaaaatac   2400

agtctttgta gataccaaga agttgcctat aatcaagaag aaagtgagga agttggaaga   2460

tcagaacgag tatgaatccc gcagcctttg gaaggatgtc actttcaact taaaaatcag   2520

agacattgat gcagcaactg aagcaaagca caggcttgaa gaaagacaaa gagcagaagc   2580

ccgagaaagg aaggagaagg aaattcagtg ggagacaagg ttatttcatg aagatggaga   2640

atgctgggtt tatgatgaac cattactgaa acgtcttggt gctgccaagc attaggttgg   2700

aagatgcaaa gtttatacct gatgatcagg gcagtaggca taattcagca acaaacaatc   2760

ttcctttggg agaaacctgt tcattccaat cttctaatta cagtggttcc tatctcaggg   2820

atactggact ttctgacgca gatgaacaat taaggggaaa agcttccctt ttccctctgt   2880

ggcagttacg attttgactt cagtcctgag aaaaacttca ggttttgaaa atcagatgat   2940

gtcttctcct tttccaaaca ccacacgttg aaagcattta taaatccaag tctgaaactc   3000

tgcgctctag tactgctgtt aagatacaca acttgtttct tagttcatat aatctcggga   3060

tacacacaca cacacacata tatatacaca cacatacgta tacacacaca tacatatata   3120

taaatatacc tgatgccaga tttttttcat aaatattctg cctactgtaa atatgggttc   3180

ctctgagttg ttttagaaaa ttagcgcaat gtattaaaat caagtgttag gaaatttcat   3240

ggtcttacct acaataactt ttattttgga attgaactat tattaaattg tatctaatcc   3300

tggattacag tttaattaat tattcttagt gcttaaggct tcataaagta atttttccaa   3360

cctttttttt                                                          3370


<210>  6380
<211>  521
<212>  PRT
<213>  Homosapiens

<400>  6380

Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro Val Gln Leu Cys Lys 
1               5                   10                  15      


Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly Pro Val Leu Ala Thr 
            20                  25                  30          


Leu Gly His His Gln Thr Pro Thr Pro Asn Ser Thr Gly Ser Gly His 
        35                  40                  45              


Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser His Val Asn Leu Ser 
    50                  55                  60                  


Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser Ser Glu Asp Glu Phe 
65                  70                  75                  80  


Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser Ser Pro Lys Arg Leu 
                85                  90                  95      


Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr His Ser Ser Ser Gly 
            100                 105                 110         


Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser Leu Asn Ser Ser Leu 
        115                 120                 125             


Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp Ser His Asp Asp Arg 
    130                 135                 140                 


Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu His Lys Ser Val Ile 
145                 150                 155                 160 


Met His Leu Leu Ser Gln Val Arg Leu Gly Met Asp Leu Thr Lys Val 
                165                 170                 175     


Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser Leu Leu Glu Met Tyr 
            180                 185                 190         


Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val Ser Ile Ser Asp Gln 
        195                 200                 205             


Lys Asp Pro Lys Asp Arg Met Val Gln Val Val Lys Trp Tyr Leu Ser 
    210                 215                 220                 


Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala Lys Lys Pro Tyr Asn 
225                 230                 235                 240 


Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp Thr Leu Pro Asn Asp 
                245                 250                 255     


Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly Pro Val Pro Trp Val 
            260                 265                 270         


Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln Val Ser His His Pro 
        275                 280                 285             


Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn Lys Lys Ile Gln Phe 
    290                 295                 300                 


Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu Gly Met Ser Ile Gly 
305                 310                 315                 320 


Val His Asn Ile Gly Gln Gly Cys Val Ser Cys Leu Asp Tyr Asp Glu 
                325                 330                 335     


His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly Arg Ser Ile Leu Thr 
            340                 345                 350         


Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn Ile Asn Cys Ser Lys 
        355                 360                 365             


Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr Lys Pro Phe Tyr Gly 
    370                 375                 380                 


Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe Ser Pro Asn Asp Lys 
385                 390                 395                 400 


Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn Gly Val Met Tyr Ala 
                405                 410                 415     


Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val Asp Thr Lys Lys Leu 
            420                 425                 430         


Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu Asp Gln Asn Glu Tyr 
        435                 440                 445             


Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe Asn Leu Lys Ile Arg 
    450                 455                 460                 


Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg Leu Glu Glu Arg Gln 
465                 470                 475                 480 


Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu Ile Gln Trp Glu Thr 
                485                 490                 495     


Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val Tyr Asp Glu Pro Leu 
            500                 505                 510         


Leu Lys Arg Leu Gly Ala Ala Lys His 
        515                 520     


<210>  6381
<211>  5373
<212>  DNA
<213>  Homosapiens

<400>  6381
cttctaaatg gtaaatgtaa actttgctgt ggcaaagact ttggtttaac atgtacacac     60

tcgcaccccc ctgctgccct atggagtttt ctttttaaaa tgccttcatg ctgtcagaat    120

aatttcttga cttagaatca gagaatccta gacttttctc ccctctaaaa ttaactacat    180

gtctgaattt ttctccctct cttctgaatc ctcagaaagc aagccctctt ctctacactc    240

cccagttaga agatgcatct ctttctcttt agtgaccata aaactagaca cacagtcagc    300

cttctgcatc tgtggattca accaaccatg gattcaaaat atttgaggaa aaaaaaagta    360

cctctttact gaatatgtat atactgtttt ccttgtcatg atttcctaaa caatacagta    420

taatggtgat ttatataata tttacataat attaggtgtc ataagtaatt tagagatgat    480

ttaacttata tgggagcgta tgtgtaggtt gtatgcaaat actacacgat attttatcag    540

ggacttgagt gtctgtggat tttggcatcc tcggggggtg cttggaacca gtccccctgg    600

atacctgagg agtgactgta ctgtgtgata gcagcagtat gggatggaaa gatgagatcc    660

tagtggtgca ggtacatcag ttggacattt ggtgtaactc accaaaagtg aaaaaaacag    720

agaaacaata tttgtggtga attaagagat tgagaagcac cgaattgaat tgagaggtgg    780

ttttgacttc ctgaaatctc cccacaccat tttataactc ctcagttttt ccatttagct    840

ttaccttctt ctgtgacaga gattcattca ttgtctttcc ttactatgct ttaagcaact    900

cttacacttc tgtatagaaa aggtgtttca ttccctcttt tcattttgat caacatatct    960

atatagctac cctcaggatt ttgaagtcat aaatgtgggc atttgggagg gtagcatgag   1020

aagagcattt aattaaaaat agctatattg tgtttcttta ttttagagta ctattaatcc   1080

cgtagatgca atatatcaac ctagtccttt ggaacctgtg atcagcacaa tgccttccca   1140

gactgtgtta cctccagaac ctgttcagtt gtgtaagtca gagcagcgtc catcttccct   1200

accagttgga cctgtgttgg ctaccttggg acatcatcag actcctacac caaatagtac   1260

aggcagtggc cattcaccac cgagtagcag tctcacttct ccaagccacg tgaacttgtc   1320

tccaaataca gtcccagagt tctcttactc cagcagtgaa gatgaatttt atgatgctga   1380

tgaattccat caaagtggct catccccaaa gcgcttaata gattcttctg gatctgcctc   1440

agtcctgaca cacagcagct cgggaaatag tctaaaacgc ccagatacca cagaatcact   1500

taattcttcc ttgtccaatg gaacaagtga tgctgacctg tttgattcac atgatgacag   1560

agatgatgat gcggaggcag ggtctgtgga ggagcacaag agcgttatca tgcatctctt   1620

gtcgcaggtt agacttggaa tggatcttac taaggtagtt cttccaacgt ttattcttga   1680

aagaagatct cttttagaaa tgtatgcaga cttttttgca catccggacc tgtttgtgag   1740

cattagtgac cagaaggatc ccaaggatcg aatggttcag gttgtgaaat ggtacctctc   1800

agcctttcat gcgggaagga aaggatcagt tgccaaaaag ccatacaatc ccattttggg   1860

cgagattttt cagtgtcatt ggacattacc aaatgatact gaagagaaca cagaactagt   1920

ttcagaagga ccagttccct gggtttccaa aaacagtgta acatttgtgg ctgagcaggt   1980

ttcccatcat ccacccattt cagcctttta tgctgagtgt tttaacaaga agatacaatt   2040

caatgctcat atctggacca aatcaaaatt ccttgggatg tcaattgggg tgcacaacat   2100

agggcagggc tgtgtctcat gtctagacta tgatgaacat tacattctca cattccccaa   2160

tggctatgga aggtctatcc tcacagtgcc ctgggtggaa ttaggaggag aatgcaatat   2220

taattgttcc aaaacaggct atagtgcaaa tatcatcttc cacactaaac ccttctatgg   2280

gggcaagaag cacagaatta ctgccgagat tttttctcca aatgacaaga agtctttttg   2340

ctcaattgaa ggggaatgga atggtgtgat gtatgcaaaa tatgcaacag gggaaaatac   2400

agtctttgta gataccaaga agttgcctat aatcaagaag aaagtgagga agttggaaga   2460

tcagaacgag tatgaatccc gcagcctttg gaaggatgtc actttcaact taaaaatcag   2520

agacattgat gcagcaactg aagcaaagca caggcttgaa gaaagacaaa gagcagaagc   2580

ccgagaaagg aaggagaagg aaattcagtg ggagacaagg ttatttcatg aagatggaga   2640

atgctgggtt tatgatgaac cattactgaa acgtcttggt gctgccaagc attaggttgg   2700

aagatgcaaa gtttatacct gatgatcagg gcagtaggca taattcagca acaaacaatc   2760

ttcctttggg agaaacctgt tcattccaat cttctaatta cagtggttcc tatctcaggg   2820

atactggact ttctgacgca gatgaacaat taaggggaaa agcttccctt ttccctctgt   2880

ggcagttacg attttgactt cagtcctgag aaaaacttca ggttttgaaa atcagatgat   2940

gtcttctcct tttccaaaca ccacacgttg aaagcattta taaatccaag tctgaaactc   3000

tgcgctctag tactgctgtt aagatacaca acttgtttct tagttcatat aatctcggga   3060

tacacacaca cacacacata tatatacaca cacatacgta tacacacaca tacatatata   3120

taaatatacc tgatgccaga tttttttcat aaatattctg cctactgtaa atatgggttc   3180

ctctgagttg ttttagaaaa ttagcgcaat gtattaaaat caagtgttag gaaatttcat   3240

ggtcttacct acaataactt ttattttgga attgaactat tattaaattg tatctaatcc   3300

tggattacag tttaattaat tattcttagt gcttaaggct tcataaagta atttttccaa   3360

cctttttttt aaaaatgtgc atcttttatt atcttttatg gttaaacttg gaagccaatt   3420

atttggcaac cttgaataca agagctagct tttcaaagaa agacacttga aataatggag   3480

gatccattct tttcctctgt cagattgtat gttctgtctt tagcccctgc caggcaattc   3540

cccagaatct tcacttaact catattgcac atgtagggct gcctaccaac attttatcca   3600

aaaatgtttt attgccttag agggtttggg aagagtgtgt atttatagat ccccacccca   3660

cagtgaacaa aaatagatag atagatagaa taaaatgaat gccacagcag cagatggctc   3720

attctgaagg gaaatacaga actatatcta tctatctatc tatcatcttt tttatttaaa   3780

aatacattaa aaaaacaggt attagtacct agcatttagt tagttattca atatactggt   3840

tacgtaaggc ctttcaagaa gtagattctc agtctgagag gacacaggcc agggcttctc   3900

aaagtgctgc tgcaggcttt ctggtctcgc ttggcccatt ctgctaattt tcctttgcca   3960

gctcctacag taaccctggg tttattagtc tcaacaaagg ataaaaagta aatcaaatgc   4020

tatgatgcca gtgcaaaact tcaatggaag ccctaaggca gtagtataac taactccata   4080

aaatacaaac aaacacattt taaaatacac attgcttcag gccaacgtga ctgcagttta   4140

tttatttgac tattttatgg taggggagaa ggttgagtgt tgttgtgaaa gccctgatat   4200

cagtaatggg gatgatacaa tctgccagca gaggagaggt tggcaggtag gtcagctgca   4260

tcacttcaca agaagaattt gaatcctcac tagaaggggt accatcctct tccagttcat   4320

acttcccata tccaacaacc tgaaagagga caaagacaaa agtgaaaaat atgctgacca   4380

gatttagggg tttaagagtt ctgatgataa ccacccaaac tcactcagta aatgacaacc   4440

ctagaatgga tggagttagt taaacatact cacatgaacg ctgagcattt tacttcctgg   4500

ccctctatgg gccttgaacc agttgaccag gtctgatttt gagaatgact tcagtgcttc   4560

aatcttacaa gggaagggaa gataggaaag aaattcaaga agaaagatag ctcttaaacc   4620

taacccccag gcagatgtcc ctggacctgc ttagcatctg aagacctcat tttattcttc   4680

ctattctcag gttaccccta accttccaga ccaaaacgat gatgaagctc tctggcatgc   4740

cttcacattt tataccaatc atctacaatg gcaagagagg ttagcagatg ctataattac   4800

agctaaatac catacactga gcccaacacc cacatcccct tagtgtcacc tcccaattac   4860

atggtagctg cataccacgg cttgaggaaa tctaccttgc ttctattaag aaaactaaaa   4920

tgtgttaaga tgaagcctct tactaaataa cctctttaca tcacagagca atgatgtcct   4980

atggtaattc accatgtagg ggctatgtat taaccaaagt cacactggag tacaagatcc   5040

agatcttttt cataggtttt actactttgg aatagaagtt gtcaaaacac atgcacttgg   5100

aataatgaac tccgtaaaga caaagagtcc tcaattttct ttaaacggca aaactctttt   5160

tctccacaaa atcttgtaga cctcaatata tagcataaaa atagagctgc tctgattgaa   5220

attggtggtg gtgtggtaag gattagcacc cagctcacgt ggccacctaa ggtgctagag   5280

aggccagtct gaaaactcag gaagtgagcg agtaatcagg ccaggactag tgtttcgagt   5340

ttctcttcca cacaatgctg gtgtgcacag acc                                5373


<210>  6382
<211>  521
<212>  PRT
<213>  Homosapiens

<400>  6382

Met Pro Ser Gln Thr Val Leu Pro Pro Glu Pro Val Gln Leu Cys Lys 
1               5                   10                  15      


Ser Glu Gln Arg Pro Ser Ser Leu Pro Val Gly Pro Val Leu Ala Thr 
            20                  25                  30          


Leu Gly His His Gln Thr Pro Thr Pro Asn Ser Thr Gly Ser Gly His 
        35                  40                  45              


Ser Pro Pro Ser Ser Ser Leu Thr Ser Pro Ser His Val Asn Leu Ser 
    50                  55                  60                  


Pro Asn Thr Val Pro Glu Phe Ser Tyr Ser Ser Ser Glu Asp Glu Phe 
65                  70                  75                  80  


Tyr Asp Ala Asp Glu Phe His Gln Ser Gly Ser Ser Pro Lys Arg Leu 
                85                  90                  95      


Ile Asp Ser Ser Gly Ser Ala Ser Val Leu Thr His Ser Ser Ser Gly 
            100                 105                 110         


Asn Ser Leu Lys Arg Pro Asp Thr Thr Glu Ser Leu Asn Ser Ser Leu 
        115                 120                 125             


Ser Asn Gly Thr Ser Asp Ala Asp Leu Phe Asp Ser His Asp Asp Arg 
    130                 135                 140                 


Asp Asp Asp Ala Glu Ala Gly Ser Val Glu Glu His Lys Ser Val Ile 
145                 150                 155                 160 


Met His Leu Leu Ser Gln Val Arg Leu Gly Met Asp Leu Thr Lys Val 
                165                 170                 175     


Val Leu Pro Thr Phe Ile Leu Glu Arg Arg Ser Leu Leu Glu Met Tyr 
            180                 185                 190         


Ala Asp Phe Phe Ala His Pro Asp Leu Phe Val Ser Ile Ser Asp Gln 
        195                 200                 205             


Lys Asp Pro Lys Asp Arg Met Val Gln Val Val Lys Trp Tyr Leu Ser 
    210                 215                 220                 


Ala Phe His Ala Gly Arg Lys Gly Ser Val Ala Lys Lys Pro Tyr Asn 
225                 230                 235                 240 


Pro Ile Leu Gly Glu Ile Phe Gln Cys His Trp Thr Leu Pro Asn Asp 
                245                 250                 255     


Thr Glu Glu Asn Thr Glu Leu Val Ser Glu Gly Pro Val Pro Trp Val 
            260                 265                 270         


Ser Lys Asn Ser Val Thr Phe Val Ala Glu Gln Val Ser His His Pro 
        275                 280                 285             


Pro Ile Ser Ala Phe Tyr Ala Glu Cys Phe Asn Lys Lys Ile Gln Phe 
    290                 295                 300                 


Asn Ala His Ile Trp Thr Lys Ser Lys Phe Leu Gly Met Ser Ile Gly 
305                 310                 315                 320 


Val His Asn Ile Gly Gln Gly Cys Val Ser Cys Leu Asp Tyr Asp Glu 
                325                 330                 335     


His Tyr Ile Leu Thr Phe Pro Asn Gly Tyr Gly Arg Ser Ile Leu Thr 
            340                 345                 350         


Val Pro Trp Val Glu Leu Gly Gly Glu Cys Asn Ile Asn Cys Ser Lys 
        355                 360                 365             


Thr Gly Tyr Ser Ala Asn Ile Ile Phe His Thr Lys Pro Phe Tyr Gly 
    370                 375                 380                 


Gly Lys Lys His Arg Ile Thr Ala Glu Ile Phe Ser Pro Asn Asp Lys 
385                 390                 395                 400 


Lys Ser Phe Cys Ser Ile Glu Gly Glu Trp Asn Gly Val Met Tyr Ala 
                405                 410                 415     


Lys Tyr Ala Thr Gly Glu Asn Thr Val Phe Val Asp Thr Lys Lys Leu 
            420                 425                 430         


Pro Ile Ile Lys Lys Lys Val Arg Lys Leu Glu Asp Gln Asn Glu Tyr 
        435                 440                 445             


Glu Ser Arg Ser Leu Trp Lys Asp Val Thr Phe Asn Leu Lys Ile Arg 
    450                 455                 460                 


Asp Ile Asp Ala Ala Thr Glu Ala Lys His Arg Leu Glu Glu Arg Gln 
465                 470                 475                 480 


Arg Ala Glu Ala Arg Glu Arg Lys Glu Lys Glu Ile Gln Trp Glu Thr 
                485                 490                 495     


Arg Leu Phe His Glu Asp Gly Glu Cys Trp Val Tyr Asp Glu Pro Leu 
            500                 505                 510         


Leu Lys Arg Leu Gly Ala Ala Lys His 
        515                 520     


<210>  6383
<211>  852
<212>  DNA
<213>  Homosapiens

<400>  6383
tcccttgtaa gattgaagca ctgaagtcat tctcaaaatc agacctggtc aactggttca     60

aggcccatag agggccagga agtaaaatgc tcagcgttca tgttgttgga tatgggaagt    120

atgaactgga agaggatggt accccttcta gtgaggattc aaattcttct tgtgaagtga    180

tgcagctgac ctacctgcca acctctcctc tgctggcaga ttgtatcatc cccattactg    240

atatcagggc tttcacaaca acactcaacc ttctccccta ccataaaata gtcaaataaa    300

taaactgcag tcacgttggc ctgaagcaat gtgtatttta aaatgtgttt gtttgtattt    360

tatggagtta gttatactac tgccttaggg cttccattga agttttgcac tggcatcata    420

gcatttgatt tactttttat cctttgttga gactaataaa cccagggtta ctgtaggagc    480

tggcaaagga aaattagcag aatgggccaa gcgagaccag aaagcctgca gcagcacttt    540

gagaagccct ggcctgtgtc ctctcagact gagaatctac ttcttgaaag gccttacgta    600

accagtatat tgaataacta actaaatgct aggtactaat acctgttttt ttaatgtatt    660

tttaaataaa aaagatgata gatagataga tagatatagt tctgtatttc ccttcagaat    720

gagccatctg ctgctgtggc attcatttta ttctatctat ctatctattt ttgttcactg    780

tggggtgggg atctataaat acacactctt cccaaaccct ctaaggcaat aaaacatttt    840

tggataaaat gt                                                        852


<210>  6384
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  6384

Met Leu Ser Val His Val Val Gly Tyr Gly Lys Tyr Glu Leu Glu Glu 
1               5                   10                  15      


Asp Gly Thr Pro Ser Ser Glu Asp Ser Asn Ser Ser Cys Glu Val Met 
            20                  25                  30          


Gln Leu Thr Tyr Leu Pro Thr Ser Pro Leu Leu Ala Asp Cys Ile Ile 
        35                  40                  45              


Pro Ile Thr Asp Ile Arg Ala Phe Thr Thr Thr Leu Asn Leu Leu Pro 
    50                  55                  60                  


Tyr His Lys Ile Val Lys 
65                  70  


<210>  6385
<211>  1614
<212>  DNA
<213>  Homosapiens

<400>  6385
gaaacactag tcctggcctg attactcgct cacttcctga gttttcagac tggcctctct     60

agcaccttag gtggccacgt gagctgggtg ctaatcctta ccacaccacc accaatttca    120

atcagagcag ctctattttt atgctatata ttgaggtcta caagattttg tggagaaaaa    180

gagttttgcc gtttaaagaa aattgaggac tctttgtctt tacggagttc attattccaa    240

gtgcatgtgt tttgacaact tctattccaa agtagtaaaa cctatgaaaa agatctggat    300

cttgtactcc agtgtgactt tggttaatac atagccccta catggtgaat taccatagga    360

catcattgct ctgtgatgta aagaggttat ttagtaagag gcttcatctt aacacatttt    420

agttttctta atagaagcaa ggtagatttc ctcaagccgt ggtatgcagc taccatgtaa    480

ttgggaggtg acactaaggg gatgtgggtg ttgggctcag tgtatggtat ttagctgtaa    540

ttatagcatc tgctaacctc tcttgccatt gtagatgatt ggtataaaat gtgaaggcat    600

gccagagagc ttcatcatcg ttttggtctg gaaggttagg ggtaacctga gaataggaag    660

aataaaatga ggtcttcaga tgctaagcag gtccagggac atctgcctgg gggttaggtt    720

taagagctat ctttcttctt gaatttcttt cctatcttcc cttcccttgt aagattgaag    780

cactgaagtc attctcaaaa tcagacctgg tcaactggtt caaggcccat agagggccag    840

gaagtaaaat gctcagcgtt catgttgttg gatatgggaa gtatgaactg gaagaggatg    900

gtaccccttc tagtgaggat tcaaattctt cttgtgaagt gatgcagctg acctacctgc    960

caacctctcc tctgctggca gattgtatca tccccattac tgatatcagg gctttcacaa   1020

caacactcaa ccttctcccc taccataaaa tagtcaaata aataaactgc agtcacgttg   1080

gcctgaagca atgtgtattt taaaatgtgt ttgtttgtat tttatggagt tagttatact   1140

actgccttag ggcttccatt gaagttttgc actggcatca tagcatttga tttacttttt   1200

atcctttgtt gagactaata aacccagggt tactgtagga gctggcaaag gaaaattagc   1260

agaatgggcc aagcgagacc agaaagcctg cagcagcact ttgagaagcc ctggcctgtg   1320

tcctctcaga ctgagaatct acttcttgaa aggccttacg taaccagtat attgaataac   1380

taactaaatg ctaggtacta atacctgttt ttttaatgta tttttaaata aaaaagatga   1440

tagatagata gatagatata gttctgtatt tcccttcaga atgagccatc tgctgctgtg   1500

gcattcattt tattctatct atctatctat ttttgttcac tgtggggtgg ggatctataa   1560

atacacactc ttcccaaacc ctctaaggca ataaaacatt tttggataaa atgt         1614


<210>  6386
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  6386

Met Leu Ser Val His Val Val Gly Tyr Gly Lys Tyr Glu Leu Glu Glu 
1               5                   10                  15      


Asp Gly Thr Pro Ser Ser Glu Asp Ser Asn Ser Ser Cys Glu Val Met 
            20                  25                  30          


Gln Leu Thr Tyr Leu Pro Thr Ser Pro Leu Leu Ala Asp Cys Ile Ile 
        35                  40                  45              


Pro Ile Thr Asp Ile Arg Ala Phe Thr Thr Thr Leu Asn Leu Leu Pro 
    50                  55                  60                  


Tyr His Lys Ile Val Lys 
65                  70  


<210>  6387
<211>  3749
<212>  DNA
<213>  Homosapiens

<400>  6387
tctcccccca gatacatcaa attacagaat ggcttgcagg cacttctgat ttcagaccta     60

agtaatatgg aaggtaaaac aggaaataca acagatgatg aagaagaaga ggaggtggag    120

gaagaagaag aagatgatga tgaagattct ggagctgaaa tagaagatga cgatgaagag    180

ggttttgatg atgaagatga gtttgatgat gaacatgatg atgatcttga tactgaggat    240

aatgaattgg aagaattaga agagagagca gaagctagaa aaaaaactac tgaaaaacag    300

gtctgcacct gttcagcatt tggcaggatg gcaagcggag gagcagcagg gtgaaactga    360

cacagttctg tctgcagcgg ctctttgtgt tggagttggg agtttcgctg atccagatga    420

cctgccgggg ctggcacact ttttggagca catggtattc atgggtagtt tgaaatatcc    480

agatgagaat ggatttgatg ccttcctgaa gaagcatggg ggtagtgata atgcctcaac    540

tgattgtgaa cgcactgtct ttcagtttga tgtccagagg aagtacttca aggaagctct    600

tgatagatgg gcgcagttct tcatccaccc actaatgatc agagatgcaa ttgaccgtga    660

agttgaagct gttgatagtg aatatcaact tgcaaggcct tctgatgcaa acagaaagga    720

aatgttgttt ggaagccttg ctagacctgg acatcctatg ggaaaatttt tttggggaaa    780

tgctgagacg ctcaagcatg agccaagaaa gaataatatt gatacacatg ctagattgag    840

agaattctgg atgcgttact actcttctca ttacatgact ttagtggttc aatccaaaga    900

aacactggat actttggaaa agtgggtgac tgaaatcttc tctcagatac caaacaatgg    960

gttacccaga ccaaactttg gccatttaac ggatccattt gacacaccag catttaacaa   1020

actttataga gttgttccaa tcagaaaaat tcatgctctg accatcacat gggcacttcc   1080

tcctcaacag caacattaca gggtgaagcc acttcattat atatcctggc tggttggaca   1140

tgaaggcaaa ggcagcattc tttctttcct taggaaaaaa tgctgggctc ttgcactgtt   1200

tggtggaaat ggtgagacag gatttgagca aaattctact tattcagtgt tcagcatttc   1260

tattacattg actgatgagg gttatgaaca tttttatgag gttgcttaca ctgtctttca   1320

gtatttaaaa atgctgcaga agctaggccc agaaaaaaga atttttgaag agattcggaa   1380

aattgaggat aatgaatttc attaccaaga acagacagat ccagttgagt atgtggaaaa   1440

catgtgtgag aacatgcagc tgtacccatt gcaggacatt ctcactggag atcagcttct   1500

ttttgaatac aagccagaag tcattggtga agccttgaat cagctagttc ctcaaaaagc   1560

aaatcttgtt ttactgtctg gtgctaatga gggaaaatgt gacctcaagg agaaatggtt   1620

tggaactcaa tatagtatag aagatattga aaactcttgg gctgaactgt ggaatagtaa   1680

tttcgaatta aatccagatc ttcatcttcc agctgaaaac aagtacatag ccacggactt   1740

tacgttgaag gctttcgatt gcccggaaac agaataccca gttaaaattg tgaatactcc   1800

acaaggttgc ctgtggtata agaaagacaa caaattcaaa atccccaaag catatatacg   1860

tttccatcta atttcaccgt tgatacagaa atctgcagca aatgtggtcc tctttgatat   1920

ctttgtcaat atccttacgc ataaccttgc ggaaccagct tatgaagcag atgtggcaca   1980

gctggagtat aaactggtag ctggagaaca tggtttaatt attcgagtga aaggatttaa   2040

ccacaaacta cctctactgt ttcagctcat tattgactac ttagctgagt tcaattccac   2100

accagctgtc tttacaatga taactgagca gttgaagaag acctacttta acatcctcat   2160

caagcccgag actttggcca aagatgtacg gcttttaatc ttggaatatg cccgttggtc   2220

tatgattgac aagtaccagg ctttgatgga cggcctttcc cttgagtctc tgctgagctt   2280

cgtcaaagaa ttcaaatccc agctctttgt ggagggcctg gtacaaggga atgtcacaag   2340

cacagaatct atggatttcc tgaaatatgt tgttgacaaa ctaaacttca agcctctgga   2400

gcaggagatg cctgtgcagt tccaggtggt agagctgccc agtggccacc atctatgcaa   2460

agtgaaagct ctgaacaagg gtgatgccaa ctctgaagtc actgtgtact accagtcagg   2520

taccaggagt ctaagagaat atacgcttat ggagctgctt gtgatgcaca tggaagaacc   2580

ttgttttgac ttccttcgaa ccaagcagac ccttgggtac catgtctacc ctacctgtag   2640

gaacacatcc gggattctag gattttctgt cactgtgggg actcaggcaa ccaaatacaa   2700

ttctgaagtt gttgataaga agatagaaga gtttctttct agctttgagg agaagattga   2760

gaacctcact gaagaggcat tcaacaccca ggtcacagct ctcatcaagc tgaaggagtg   2820

tgaggatacc caccttgggg aggaggtgga taggaactgg aatgaagtgg ttacacagca   2880

gtacctcttt gaccgccttg cccacgagat tgaagcactg aagtcattct caaaatcaga   2940

cctggtcaac tggttcaagg cccatagagg gccaggaagt aaaatgctca gcgttcatgt   3000

tgttggatat gggaagtatg aactggaaga ggatggtacc ccttctagtg aggattcaaa   3060

ttcttcttgt gaagtgatgc agctgaccta cctgccaacc tctcctctgc tggcagattg   3120

tatcatcccc attactgata tcagggcttt cacaacaaca ctcaaccttc tcccctacca   3180

taaaatagtc aaataaataa actgcagtca cgttggcctg aagcaatgtg tattttaaaa   3240

tgtgtttgtt tgtattttat ggagttagtt atactactgc cttagggctt ccattgaagt   3300

tttgcactgg catcatagca tttgatttac tttttatcct ttgttgagac taataaaccc   3360

agggttactg taggagctgg caaaggaaaa ttagcagaat gggccaagcg agaccagaaa   3420

gcctgcagca gcactttgag aagccctggc ctgtgtcctc tcagactgag aatctacttc   3480

ttgaaaggcc ttacgtaacc agtatattga ataactaact aaatgctagg tactaatacc   3540

tgttttttta atgtattttt aaataaaaaa gatgatagat agatagatag atatagttct   3600

gtatttccct tcagaatgag ccatctgctg ctgtggcatt cattttattc tatctatcta   3660

tctatttttg ttcactgtgg ggtggggatc tataaataca cactcttccc aaaccctcta   3720

aggcaataaa acatttttgg ataaaatgt                                     3749


<210>  6388
<211>  914
<212>  PRT
<213>  Homosapiens

<400>  6388

Met Val Phe Met Gly Ser Leu Lys Tyr Pro Asp Glu Asn Gly Phe Asp 
1               5                   10                  15      


Ala Phe Leu Lys Lys His Gly Gly Ser Asp Asn Ala Ser Thr Asp Cys 
            20                  25                  30          


Glu Arg Thr Val Phe Gln Phe Asp Val Gln Arg Lys Tyr Phe Lys Glu 
        35                  40                  45              


Ala Leu Asp Arg Trp Ala Gln Phe Phe Ile His Pro Leu Met Ile Arg 
    50                  55                  60                  


Asp Ala Ile Asp Arg Glu Val Glu Ala Val Asp Ser Glu Tyr Gln Leu 
65                  70                  75                  80  


Ala Arg Pro Ser Asp Ala Asn Arg Lys Glu Met Leu Phe Gly Ser Leu 
                85                  90                  95      


Ala Arg Pro Gly His Pro Met Gly Lys Phe Phe Trp Gly Asn Ala Glu 
            100                 105                 110         


Thr Leu Lys His Glu Pro Arg Lys Asn Asn Ile Asp Thr His Ala Arg 
        115                 120                 125             


Leu Arg Glu Phe Trp Met Arg Tyr Tyr Ser Ser His Tyr Met Thr Leu 
    130                 135                 140                 


Val Val Gln Ser Lys Glu Thr Leu Asp Thr Leu Glu Lys Trp Val Thr 
145                 150                 155                 160 


Glu Ile Phe Ser Gln Ile Pro Asn Asn Gly Leu Pro Arg Pro Asn Phe 
                165                 170                 175     


Gly His Leu Thr Asp Pro Phe Asp Thr Pro Ala Phe Asn Lys Leu Tyr 
            180                 185                 190         


Arg Val Val Pro Ile Arg Lys Ile His Ala Leu Thr Ile Thr Trp Ala 
        195                 200                 205             


Leu Pro Pro Gln Gln Gln His Tyr Arg Val Lys Pro Leu His Tyr Ile 
    210                 215                 220                 


Ser Trp Leu Val Gly His Glu Gly Lys Gly Ser Ile Leu Ser Phe Leu 
225                 230                 235                 240 


Arg Lys Lys Cys Trp Ala Leu Ala Leu Phe Gly Gly Asn Gly Glu Thr 
                245                 250                 255     


Gly Phe Glu Gln Asn Ser Thr Tyr Ser Val Phe Ser Ile Ser Ile Thr 
            260                 265                 270         


Leu Thr Asp Glu Gly Tyr Glu His Phe Tyr Glu Val Ala Tyr Thr Val 
        275                 280                 285             


Phe Gln Tyr Leu Lys Met Leu Gln Lys Leu Gly Pro Glu Lys Arg Ile 
    290                 295                 300                 


Phe Glu Glu Ile Arg Lys Ile Glu Asp Asn Glu Phe His Tyr Gln Glu 
305                 310                 315                 320 


Gln Thr Asp Pro Val Glu Tyr Val Glu Asn Met Cys Glu Asn Met Gln 
                325                 330                 335     


Leu Tyr Pro Leu Gln Asp Ile Leu Thr Gly Asp Gln Leu Leu Phe Glu 
            340                 345                 350         


Tyr Lys Pro Glu Val Ile Gly Glu Ala Leu Asn Gln Leu Val Pro Gln 
        355                 360                 365             


Lys Ala Asn Leu Val Leu Leu Ser Gly Ala Asn Glu Gly Lys Cys Asp 
    370                 375                 380                 


Leu Lys Glu Lys Trp Phe Gly Thr Gln Tyr Ser Ile Glu Asp Ile Glu 
385                 390                 395                 400 


Asn Ser Trp Ala Glu Leu Trp Asn Ser Asn Phe Glu Leu Asn Pro Asp 
                405                 410                 415     


Leu His Leu Pro Ala Glu Asn Lys Tyr Ile Ala Thr Asp Phe Thr Leu 
            420                 425                 430         


Lys Ala Phe Asp Cys Pro Glu Thr Glu Tyr Pro Val Lys Ile Val Asn 
        435                 440                 445             


Thr Pro Gln Gly Cys Leu Trp Tyr Lys Lys Asp Asn Lys Phe Lys Ile 
    450                 455                 460                 


Pro Lys Ala Tyr Ile Arg Phe His Leu Ile Ser Pro Leu Ile Gln Lys 
465                 470                 475                 480 


Ser Ala Ala Asn Val Val Leu Phe Asp Ile Phe Val Asn Ile Leu Thr 
                485                 490                 495     


His Asn Leu Ala Glu Pro Ala Tyr Glu Ala Asp Val Ala Gln Leu Glu 
            500                 505                 510         


Tyr Lys Leu Val Ala Gly Glu His Gly Leu Ile Ile Arg Val Lys Gly 
        515                 520                 525             


Phe Asn His Lys Leu Pro Leu Leu Phe Gln Leu Ile Ile Asp Tyr Leu 
    530                 535                 540                 


Ala Glu Phe Asn Ser Thr Pro Ala Val Phe Thr Met Ile Thr Glu Gln 
545                 550                 555                 560 


Leu Lys Lys Thr Tyr Phe Asn Ile Leu Ile Lys Pro Glu Thr Leu Ala 
                565                 570                 575     


Lys Asp Val Arg Leu Leu Ile Leu Glu Tyr Ala Arg Trp Ser Met Ile 
            580                 585                 590         


Asp Lys Tyr Gln Ala Leu Met Asp Gly Leu Ser Leu Glu Ser Leu Leu 
        595                 600                 605             


Ser Phe Val Lys Glu Phe Lys Ser Gln Leu Phe Val Glu Gly Leu Val 
    610                 615                 620                 


Gln Gly Asn Val Thr Ser Thr Glu Ser Met Asp Phe Leu Lys Tyr Val 
625                 630                 635                 640 


Val Asp Lys Leu Asn Phe Lys Pro Leu Glu Gln Glu Met Pro Val Gln 
                645                 650                 655     


Phe Gln Val Val Glu Leu Pro Ser Gly His His Leu Cys Lys Val Lys 
            660                 665                 670         


Ala Leu Asn Lys Gly Asp Ala Asn Ser Glu Val Thr Val Tyr Tyr Gln 
        675                 680                 685             


Ser Gly Thr Arg Ser Leu Arg Glu Tyr Thr Leu Met Glu Leu Leu Val 
    690                 695                 700                 


Met His Met Glu Glu Pro Cys Phe Asp Phe Leu Arg Thr Lys Gln Thr 
705                 710                 715                 720 


Leu Gly Tyr His Val Tyr Pro Thr Cys Arg Asn Thr Ser Gly Ile Leu 
                725                 730                 735     


Gly Phe Ser Val Thr Val Gly Thr Gln Ala Thr Lys Tyr Asn Ser Glu 
            740                 745                 750         


Val Val Asp Lys Lys Ile Glu Glu Phe Leu Ser Ser Phe Glu Glu Lys 
        755                 760                 765             


Ile Glu Asn Leu Thr Glu Glu Ala Phe Asn Thr Gln Val Thr Ala Leu 
    770                 775                 780                 


Ile Lys Leu Lys Glu Cys Glu Asp Thr His Leu Gly Glu Glu Val Asp 
785                 790                 795                 800 


Arg Asn Trp Asn Glu Val Val Thr Gln Gln Tyr Leu Phe Asp Arg Leu 
                805                 810                 815     


Ala His Glu Ile Glu Ala Leu Lys Ser Phe Ser Lys Ser Asp Leu Val 
            820                 825                 830         


Asn Trp Phe Lys Ala His Arg Gly Pro Gly Ser Lys Met Leu Ser Val 
        835                 840                 845             


His Val Val Gly Tyr Gly Lys Tyr Glu Leu Glu Glu Asp Gly Thr Pro 
    850                 855                 860                 


Ser Ser Glu Asp Ser Asn Ser Ser Cys Glu Val Met Gln Leu Thr Tyr 
865                 870                 875                 880 


Leu Pro Thr Ser Pro Leu Leu Ala Asp Cys Ile Ile Pro Ile Thr Asp 
                885                 890                 895     


Ile Arg Ala Phe Thr Thr Thr Leu Asn Leu Leu Pro Tyr His Lys Ile 
            900                 905                 910         


Val Lys 
        


<210>  6389
<211>  3237
<212>  DNA
<213>  Homosapiens

<400>  6389
tctcccccca gatacatcaa attacagaat ggcttgcagg cacttctgat ttcagaccta     60

agtaatatgg aaggtaaaac aggaaataca acagatgatg aagaagaaga ggaggtggag    120

gaagaagaag aagatgatga tgaagattct ggagctgaaa tagaagatga cgatgaagag    180

ggttttgatg atgaagatga gtttgatgat gaacatgatg atgatcttga tactgaggat    240

aatgaattgg aagaattaga agagagagca gaagctagaa aaaaaactac tgaaaaacag    300

gtctgcacct gttcagcatt tggcaggatg gcaagcggag gagcagcagg gtgaaactga    360

cacagttctg tctgcagcgg ctctttgtgt tggagttggg agtttcgctg atccagatga    420

cctgccgggg ctggcacact ttttggagca catggtattc atgggtagtt tgaaatatcc    480

agatgagaat ggatttgatg ccttcctgaa gaagcatggg ggtagtgata atgcctcaac    540

tgattgtgaa cgcactgtct ttcagtttga tgtccagagg aagtacttca aggaagctct    600

tgatagatgg gcgcagttct tcatccaccc actaatgatc agagatgcaa ttgaccgtga    660

agttgaagct gttgatagtg aatatcaact tgcaaggcct tctgatgcaa acagaaagga    720

aatgttgttt ggaagccttg ctagacctgg acatcctatg ggaaaatttt tttggggaaa    780

tgctgagacg ctcaagcatg agccaagaaa gaataatatt gatacacatg ctagattgag    840

agaattctgg atgcgttact actcttctca ttacatgact ttagtggttc aatccaaaga    900

aacactggat actttggaaa agtgggtgac tgaaatcttc tctcagatac caaacaatgg    960

gttacccaga ccaaactttg gccatttaac ggatccattt gacacaccag catttaacaa   1020

actttataga gttgttccaa tcagaaaaat tcatgctctg accatcacat gggcacttcc   1080

tcctcaacag caacattaca gggtgaagcc acttcattat atatcctggc tggttggaca   1140

tgaaggcaaa ggcagcattc tttctttcct taggaaaaaa tgctgggctc ttgcactgtt   1200

tggtggaaat ggtgagacag gatttgagca aaattctact tattcagtgt tcagcatttc   1260

tattacattg actgatgagg gttatgaaca tttttatgag gttgcttaca ctgtctttca   1320

gtatttaaaa atgctgcaga agctaggccc agaaaaaaga atttttgaag agattcggaa   1380

aattgaggat aatgaatttc attaccaaga acagacagat ccagttgagt atgtggaaaa   1440

catgtgtgag aacatgcagc tgtacccatt gcaggacatt ctcactggag atcagcttct   1500

ttttgaatac aagccagaag tcattggtga agccttgaat cagctagttc ctcaaaaagc   1560

aaatcttgtt ttactgtctg gtgctaatga gggaaaatgt gacctcaagg agaaatggtt   1620

tggaactcaa tatagtatag aagatattga aaactcttgg gctgaactgt ggaatagtaa   1680

tttcgaatta aatccagatc ttcatcttcc agctgaaaac aagtacatag ccacggactt   1740

tacgttgaag gctttcgatt gcccggaaac agaataccca gttaaaattg tgaatactcc   1800

acaaggttgc ctgtggtata agaaagacaa caaattcaaa atccccaaag catatatacg   1860

tttccatcta atttcaccgt tgatacagaa atctgcagca aatgtggtcc tctttgatat   1920

ctttgtcaat atccttacgc ataaccttgc ggaaccagct tatgaagcag atgtggcaca   1980

gctggagtat aaactggtag ctggagaaca tggtttaatt attcgagtga aaggatttaa   2040

ccacaaacta cctctactgt ttcagctcat tattgactac ttagctgagt tcaattccac   2100

accagctgtc tttacaatga taactgagca gttgaagaag acctacttta acatcctcat   2160

caagcccgag actttggcca aagatgtacg gcttttaatc ttggaatatg cccgttggtc   2220

tatgattgac aagtaccagg ctttgatgga cggcctttcc cttgagtctc tgctgagctt   2280

cgtcaaagaa ttcaaatccc agctctttgt ggagggcctg gtacaaggga atgtcacaag   2340

cacagaatct atggatttcc tgaaatatgt tgttgacaaa ctaaacttca agcctctgga   2400

gcaggagatg cctgtgcagt tccaggtggt agagctgccc agtggccacc atctatgcaa   2460

agtgaaagct ctgaacaagg gtgatgccaa ctctgaagtc actgtgtact accagtcagg   2520

taccaggagt ctaagagaat atacgcttat ggagctgctt gtgatgcaca tggaagaacc   2580

ttgttttgac ttccttcgaa ccaagcagac ccttgggtac catgtctacc ctacctgtag   2640

gaacacatcc gggattctag gattttctgt cactgtgggg actcaggcaa ccaaatacaa   2700

ttctgaagtt gttgataaga agatagaaga gtttctttct agctttgagg agaagattga   2760

gaacctcact gaagaggcat tcaacaccca ggtcacagct ctcatcaagc tgaaggagtg   2820

tgaggatacc caccttgggg aggaggtgga taggaactgg aatgaagtgg ttacacagca   2880

gtacctcttt gaccgccttg cccacgagat tgaagcactg aagtcattct caaaatcaga   2940

cctggtcaac tggttcaagg cccatagagg gccaggaagt aaaatgctca gcgttcatgt   3000

tgttggatat gggaagtatg aactggaaga ggatggtacc ccttctagtg aggattcaaa   3060

ttcttcttgt gaagtgatgc agctgaccta cctgccaacc tctcctctgc tggcagattg   3120

tatcatcccc attactgata tcagggcttt cacaacaaca ctcaaccttc tcccctacca   3180

taaaatagtc aaataaataa actgcagtca cgttggcctg aagcaatgtg tatttta      3237


<210>  6390
<211>  914
<212>  PRT
<213>  Homosapiens

<400>  6390

Met Val Phe Met Gly Ser Leu Lys Tyr Pro Asp Glu Asn Gly Phe Asp 
1               5                   10                  15      


Ala Phe Leu Lys Lys His Gly Gly Ser Asp Asn Ala Ser Thr Asp Cys 
            20                  25                  30          


Glu Arg Thr Val Phe Gln Phe Asp Val Gln Arg Lys Tyr Phe Lys Glu 
        35                  40                  45              


Ala Leu Asp Arg Trp Ala Gln Phe Phe Ile His Pro Leu Met Ile Arg 
    50                  55                  60                  


Asp Ala Ile Asp Arg Glu Val Glu Ala Val Asp Ser Glu Tyr Gln Leu 
65                  70                  75                  80  


Ala Arg Pro Ser Asp Ala Asn Arg Lys Glu Met Leu Phe Gly Ser Leu 
                85                  90                  95      


Ala Arg Pro Gly His Pro Met Gly Lys Phe Phe Trp Gly Asn Ala Glu 
            100                 105                 110         


Thr Leu Lys His Glu Pro Arg Lys Asn Asn Ile Asp Thr His Ala Arg 
        115                 120                 125             


Leu Arg Glu Phe Trp Met Arg Tyr Tyr Ser Ser His Tyr Met Thr Leu 
    130                 135                 140                 


Val Val Gln Ser Lys Glu Thr Leu Asp Thr Leu Glu Lys Trp Val Thr 
145                 150                 155                 160 


Glu Ile Phe Ser Gln Ile Pro Asn Asn Gly Leu Pro Arg Pro Asn Phe 
                165                 170                 175     


Gly His Leu Thr Asp Pro Phe Asp Thr Pro Ala Phe Asn Lys Leu Tyr 
            180                 185                 190         


Arg Val Val Pro Ile Arg Lys Ile His Ala Leu Thr Ile Thr Trp Ala 
        195                 200                 205             


Leu Pro Pro Gln Gln Gln His Tyr Arg Val Lys Pro Leu His Tyr Ile 
    210                 215                 220                 


Ser Trp Leu Val Gly His Glu Gly Lys Gly Ser Ile Leu Ser Phe Leu 
225                 230                 235                 240 


Arg Lys Lys Cys Trp Ala Leu Ala Leu Phe Gly Gly Asn Gly Glu Thr 
                245                 250                 255     


Gly Phe Glu Gln Asn Ser Thr Tyr Ser Val Phe Ser Ile Ser Ile Thr 
            260                 265                 270         


Leu Thr Asp Glu Gly Tyr Glu His Phe Tyr Glu Val Ala Tyr Thr Val 
        275                 280                 285             


Phe Gln Tyr Leu Lys Met Leu Gln Lys Leu Gly Pro Glu Lys Arg Ile 
    290                 295                 300                 


Phe Glu Glu Ile Arg Lys Ile Glu Asp Asn Glu Phe His Tyr Gln Glu 
305                 310                 315                 320 


Gln Thr Asp Pro Val Glu Tyr Val Glu Asn Met Cys Glu Asn Met Gln 
                325                 330                 335     


Leu Tyr Pro Leu Gln Asp Ile Leu Thr Gly Asp Gln Leu Leu Phe Glu 
            340                 345                 350         


Tyr Lys Pro Glu Val Ile Gly Glu Ala Leu Asn Gln Leu Val Pro Gln 
        355                 360                 365             


Lys Ala Asn Leu Val Leu Leu Ser Gly Ala Asn Glu Gly Lys Cys Asp 
    370                 375                 380                 


Leu Lys Glu Lys Trp Phe Gly Thr Gln Tyr Ser Ile Glu Asp Ile Glu 
385                 390                 395                 400 


Asn Ser Trp Ala Glu Leu Trp Asn Ser Asn Phe Glu Leu Asn Pro Asp 
                405                 410                 415     


Leu His Leu Pro Ala Glu Asn Lys Tyr Ile Ala Thr Asp Phe Thr Leu 
            420                 425                 430         


Lys Ala Phe Asp Cys Pro Glu Thr Glu Tyr Pro Val Lys Ile Val Asn 
        435                 440                 445             


Thr Pro Gln Gly Cys Leu Trp Tyr Lys Lys Asp Asn Lys Phe Lys Ile 
    450                 455                 460                 


Pro Lys Ala Tyr Ile Arg Phe His Leu Ile Ser Pro Leu Ile Gln Lys 
465                 470                 475                 480 


Ser Ala Ala Asn Val Val Leu Phe Asp Ile Phe Val Asn Ile Leu Thr 
                485                 490                 495     


His Asn Leu Ala Glu Pro Ala Tyr Glu Ala Asp Val Ala Gln Leu Glu 
            500                 505                 510         


Tyr Lys Leu Val Ala Gly Glu His Gly Leu Ile Ile Arg Val Lys Gly 
        515                 520                 525             


Phe Asn His Lys Leu Pro Leu Leu Phe Gln Leu Ile Ile Asp Tyr Leu 
    530                 535                 540                 


Ala Glu Phe Asn Ser Thr Pro Ala Val Phe Thr Met Ile Thr Glu Gln 
545                 550                 555                 560 


Leu Lys Lys Thr Tyr Phe Asn Ile Leu Ile Lys Pro Glu Thr Leu Ala 
                565                 570                 575     


Lys Asp Val Arg Leu Leu Ile Leu Glu Tyr Ala Arg Trp Ser Met Ile 
            580                 585                 590         


Asp Lys Tyr Gln Ala Leu Met Asp Gly Leu Ser Leu Glu Ser Leu Leu 
        595                 600                 605             


Ser Phe Val Lys Glu Phe Lys Ser Gln Leu Phe Val Glu Gly Leu Val 
    610                 615                 620                 


Gln Gly Asn Val Thr Ser Thr Glu Ser Met Asp Phe Leu Lys Tyr Val 
625                 630                 635                 640 


Val Asp Lys Leu Asn Phe Lys Pro Leu Glu Gln Glu Met Pro Val Gln 
                645                 650                 655     


Phe Gln Val Val Glu Leu Pro Ser Gly His His Leu Cys Lys Val Lys 
            660                 665                 670         


Ala Leu Asn Lys Gly Asp Ala Asn Ser Glu Val Thr Val Tyr Tyr Gln 
        675                 680                 685             


Ser Gly Thr Arg Ser Leu Arg Glu Tyr Thr Leu Met Glu Leu Leu Val 
    690                 695                 700                 


Met His Met Glu Glu Pro Cys Phe Asp Phe Leu Arg Thr Lys Gln Thr 
705                 710                 715                 720 


Leu Gly Tyr His Val Tyr Pro Thr Cys Arg Asn Thr Ser Gly Ile Leu 
                725                 730                 735     


Gly Phe Ser Val Thr Val Gly Thr Gln Ala Thr Lys Tyr Asn Ser Glu 
            740                 745                 750         


Val Val Asp Lys Lys Ile Glu Glu Phe Leu Ser Ser Phe Glu Glu Lys 
        755                 760                 765             


Ile Glu Asn Leu Thr Glu Glu Ala Phe Asn Thr Gln Val Thr Ala Leu 
    770                 775                 780                 


Ile Lys Leu Lys Glu Cys Glu Asp Thr His Leu Gly Glu Glu Val Asp 
785                 790                 795                 800 


Arg Asn Trp Asn Glu Val Val Thr Gln Gln Tyr Leu Phe Asp Arg Leu 
                805                 810                 815     


Ala His Glu Ile Glu Ala Leu Lys Ser Phe Ser Lys Ser Asp Leu Val 
            820                 825                 830         


Asn Trp Phe Lys Ala His Arg Gly Pro Gly Ser Lys Met Leu Ser Val 
        835                 840                 845             


His Val Val Gly Tyr Gly Lys Tyr Glu Leu Glu Glu Asp Gly Thr Pro 
    850                 855                 860                 


Ser Ser Glu Asp Ser Asn Ser Ser Cys Glu Val Met Gln Leu Thr Tyr 
865                 870                 875                 880 


Leu Pro Thr Ser Pro Leu Leu Ala Asp Cys Ile Ile Pro Ile Thr Asp 
                885                 890                 895     


Ile Arg Ala Phe Thr Thr Thr Leu Asn Leu Leu Pro Tyr His Lys Ile 
            900                 905                 910         


Val Lys 
        


<210>  6391
<211>  4006
<212>  DNA
<213>  Homosapiens

<400>  6391
gttcgctggc tgttccgaga atcagtccgg gtcacgttgg tgcctctcct ttcctgttct     60

gattggttgc ttacgtgagc gtgactactt tcttgcctca tgattggctg aaatcagtag    120

cgtcatcggc ggccgggagg gcggagggac gagggaagtc ggcgagaggg agactgggtt    180

gggggagggg ttcaggcctg ttccccgcgg ctgcggcagc accagggccg gccgccaccg    240

cctctagaac gcggaggagg tgggtcctgg gaagcgggat gtccatcgct ccagcttggt    300

ggtgaatgct gaggagagtc actgttgctg cagtctgtgc cacccggagg aagttgtgtg    360

aggccgggcg ggagctcgcg gcgctctggg gaatcgaaac gcggggtcgg tgcgaagact    420

ctgctgctgc cagacccttt cctattctgg ccatgcctgg aaggaacaag gcgaagtcta    480

cctgcagctg ccctgacctg cagcccaatg gacaggatct gggcgagaac agccgggttg    540

cccgtctagg agcggatgaa tctgaggaag agggacggag ggggtctctc agtaatgctg    600

gggaccctga gatcgtcaag tctcccagcg accccaagca ataccgatac atcaaattac    660

agaatggctt gcaggcactt ctgatttcag acctaagtaa tatggaaggt aaaacaggaa    720

atacaacaga tgatgaagaa gaagaggagg tggaggaaga agaagaagat gatgatgaag    780

attctggagc tgaaatagaa gatgacgatg aagagggttt tgatgatgaa gatgagtttg    840

atgatgaaca tgatgatgat cttgatactg aggataatga attggaagaa ttagaagaga    900

gagcagaagc tagaaaaaaa actactgaaa aacagcaatt gcagagcctg tttttgctgt    960

ggtcaaagct gactgataga ctgtggttta agtcaactta ttcaaaaatg tcttcaaccc   1020

tgctggtcga gacaagaaat ctttatgggg tagttggagc tgaaagcagg tctgcacctg   1080

ttcagcattt ggcaggatgg caagcggagg agcagcaggg tgaaactgac acagttctgt   1140

ctgcagcggc tctttgtgtt ggagttggga gtttcgctga tccagatgac ctgccggggc   1200

tggcacactt tttggagcac atggtattca tgggtagttt gaaatatcca gatgagaatg   1260

gatttgatgc cttcctgaag aagcatgggg gtagtgataa tgcctcaact gattgtgaac   1320

gcactgtctt tcagtttgat gtccagagga agtacttcaa ggaagctctt gatagatggg   1380

cgcagttctt catccaccca ctaatgatca gagatgcaat tgaccgtgaa gttgaagctg   1440

ttgatagtga atatcaactt gcaaggcctt ctgatgcaaa cagaaaggaa atgttgtttg   1500

gaagccttgc tagacctgga catcctatgg gaaaattttt ttggggaaat gctgagacgc   1560

tcaagcatga gccaagaaag aataatattg atacacatgc tagattgaga gaattctgga   1620

tgcgttacta ctcttctcat tacatgactt tagtggttca atccaaagaa acactggata   1680

ctttggaaaa gtgggtgact gaaatcttct ctcagatacc aaacaatggg ttacccagac   1740

caaactttgg ccatttaacg gatccatttg acacaccagc atttaacaaa ctttatagag   1800

ttgttccaat cagaaaaatt catgctctga ccatcacatg ggcacttcct cctcaacagc   1860

aacattacag ggtgaagcca cttcattata tatcctggct ggttggacat gaaggcaaag   1920

gcagcattct ttctttcctt aggaaaaaat gctgggctct tgcactgttt ggtggaaatg   1980

gtgagacagg atttgagcaa aattctactt attcagtgtt cagcatttct attacattga   2040

ctgatgaggg ttatgaacat ttttatgagg ttgcttacac tgtctttcag tatttaaaaa   2100

tgctgcagaa gctaggccca gaaaaaagaa tttttgaaga gattcggaaa attgaggata   2160

atgaatttca ttaccaagaa cagacagatc cagttgagta tgtggaaaac atgtgtgaga   2220

acatgcagct gtacccattg caggacattc tcactggaga tcagcttctt tttgaataca   2280

agccagaagt cattggtgaa gccttgaatc agctagttcc tcaaaaagca aatcttgttt   2340

tactgtctgg tgctaatgag ggaaaatgtg acctcaagga gaaatggttt ggaactcaat   2400

atagtataga agatattgaa aactcttggg ctgaactgtg gaatagtaat ttcgaattaa   2460

atccagatct tcatcttcca gctgaaaaca agtacatagc cacggacttt acgttgaagg   2520

ctttcgattg cccggaaaca gaatacccag ttaaaattgt gaatactcca caaggttgcc   2580

tgtggtataa gaaagacaac aaattcaaaa tccccaaagc atatatacgt ttccatctaa   2640

tttcaccgtt gatacagaaa tctgcagcaa atgtggtcct ctttgatatc tttgtcaata   2700

tccttacgca taaccttgcg gaaccagctt atgaagcaga tgtggcacag ctggagtata   2760

aactggtagc tggagaacat ggtttaatta ttcgagtgaa aggatttaac cacaaactac   2820

ctctactgtt tcagctcatt attgactact tagctgagtt caattccaca ccagctgtct   2880

ttacaatgat aactgagcag ttgaagaaga cctactttaa catcctcatc aagcccgaga   2940

ctttggccaa agatgtacgg cttttaatct tggaatatgc ccgttggtct atgattgaca   3000

agtaccaggc tttgatggac ggcctttccc ttgagtctct gctgagcttc gtcaaagaat   3060

tcaaatccca gctctttgtg gagggcctgg tacaagggaa tgtcacaagc acagaatcta   3120

tggatttcct gaaatatgtt gttgacaaac taaacttcaa gcctctggag caggagatgc   3180

ctgtgcagtt ccaggtggta gagctgccca gtggccacca tctatgcaaa gtgaaagctc   3240

tgaacaaggg tgatgccaac tctgaagtca ctgtgtacta ccagtcaggt accaggagtc   3300

taagagaata tacgcttatg gagctgcttg tgatgcacat ggaagaacct tgttttgact   3360

tccttcgaac caagcagacc cttgggtacc atgtctaccc tacctgtagg aacacatccg   3420

ggattctagg attttctgtc actgtgggga ctcaggcaac caaatacaat tctgaagttg   3480

ttgataagaa gatagaagag tttctttcta gctttgagga gaagattgag aacctcactg   3540

aagaggcatt caacacccag gtcacagctc tcatcaagct gaaggagtgt gaggataccc   3600

accttgggga ggaggtggat aggaactgga atgaagtggt tacacagcag tacctctttg   3660

accgccttgc ccacgagatt gaagcactga agtcattctc aaaatcagac ctggtcaact   3720

ggttcaaggc ccatagaggg ccaggaagta aaatgctcag cgttcatgtt gttggatatg   3780

ggaagtatga actggaagag gatggtaccc cttctagtga ggattcaaat tcttcttgtg   3840

aagtgatgca gctgacctac ctgccaacct ctcctctgct ggcagattgt atcatcccca   3900

ttactgatat cagggctttc acaacaacac tcaaccttct cccctaccat aaaatagtca   3960

aataaataaa ctgcagtcac gttggcctga agcaatgtgt atttta                  4006


<210>  6392
<211>  1219
<212>  PRT
<213>  Homosapiens

<400>  6392

Met Leu Arg Arg Val Thr Val Ala Ala Val Cys Ala Thr Arg Arg Lys 
1               5                   10                  15      


Leu Cys Glu Ala Gly Arg Glu Leu Ala Ala Leu Trp Gly Ile Glu Thr 
            20                  25                  30          


Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg Pro Phe Pro Ile Leu 
        35                  40                  45              


Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr Cys Ser Cys Pro Asp 
    50                  55                  60                  


Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn Ser Arg Val Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg Arg Gly Ser Leu Ser 
                85                  90                  95      


Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro Ser Asp Pro Lys Gln 
            100                 105                 110         


Tyr Arg Tyr Ile Lys Leu Gln Asn Gly Leu Gln Ala Leu Leu Ile Ser 
        115                 120                 125             


Asp Leu Ser Asn Met Glu Gly Lys Thr Gly Asn Thr Thr Asp Asp Glu 
    130                 135                 140                 


Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Asp Asp Asp Glu Asp Ser 
145                 150                 155                 160 


Gly Ala Glu Ile Glu Asp Asp Asp Glu Glu Gly Phe Asp Asp Glu Asp 
                165                 170                 175     


Glu Phe Asp Asp Glu His Asp Asp Asp Leu Asp Thr Glu Asp Asn Glu 
            180                 185                 190         


Leu Glu Glu Leu Glu Glu Arg Ala Glu Ala Arg Lys Lys Thr Thr Glu 
        195                 200                 205             


Lys Gln Gln Leu Gln Ser Leu Phe Leu Leu Trp Ser Lys Leu Thr Asp 
    210                 215                 220                 


Arg Leu Trp Phe Lys Ser Thr Tyr Ser Lys Met Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Val Glu Thr Arg Asn Leu Tyr Gly Val Val Gly Ala Glu Ser Arg Ser 
                245                 250                 255     


Ala Pro Val Gln His Leu Ala Gly Trp Gln Ala Glu Glu Gln Gln Gly 
            260                 265                 270         


Glu Thr Asp Thr Val Leu Ser Ala Ala Ala Leu Cys Val Gly Val Gly 
        275                 280                 285             


Ser Phe Ala Asp Pro Asp Asp Leu Pro Gly Leu Ala His Phe Leu Glu 
    290                 295                 300                 


His Met Val Phe Met Gly Ser Leu Lys Tyr Pro Asp Glu Asn Gly Phe 
305                 310                 315                 320 


Asp Ala Phe Leu Lys Lys His Gly Gly Ser Asp Asn Ala Ser Thr Asp 
                325                 330                 335     


Cys Glu Arg Thr Val Phe Gln Phe Asp Val Gln Arg Lys Tyr Phe Lys 
            340                 345                 350         


Glu Ala Leu Asp Arg Trp Ala Gln Phe Phe Ile His Pro Leu Met Ile 
        355                 360                 365             


Arg Asp Ala Ile Asp Arg Glu Val Glu Ala Val Asp Ser Glu Tyr Gln 
    370                 375                 380                 


Leu Ala Arg Pro Ser Asp Ala Asn Arg Lys Glu Met Leu Phe Gly Ser 
385                 390                 395                 400 


Leu Ala Arg Pro Gly His Pro Met Gly Lys Phe Phe Trp Gly Asn Ala 
                405                 410                 415     


Glu Thr Leu Lys His Glu Pro Arg Lys Asn Asn Ile Asp Thr His Ala 
            420                 425                 430         


Arg Leu Arg Glu Phe Trp Met Arg Tyr Tyr Ser Ser His Tyr Met Thr 
        435                 440                 445             


Leu Val Val Gln Ser Lys Glu Thr Leu Asp Thr Leu Glu Lys Trp Val 
    450                 455                 460                 


Thr Glu Ile Phe Ser Gln Ile Pro Asn Asn Gly Leu Pro Arg Pro Asn 
465                 470                 475                 480 


Phe Gly His Leu Thr Asp Pro Phe Asp Thr Pro Ala Phe Asn Lys Leu 
                485                 490                 495     


Tyr Arg Val Val Pro Ile Arg Lys Ile His Ala Leu Thr Ile Thr Trp 
            500                 505                 510         


Ala Leu Pro Pro Gln Gln Gln His Tyr Arg Val Lys Pro Leu His Tyr 
        515                 520                 525             


Ile Ser Trp Leu Val Gly His Glu Gly Lys Gly Ser Ile Leu Ser Phe 
    530                 535                 540                 


Leu Arg Lys Lys Cys Trp Ala Leu Ala Leu Phe Gly Gly Asn Gly Glu 
545                 550                 555                 560 


Thr Gly Phe Glu Gln Asn Ser Thr Tyr Ser Val Phe Ser Ile Ser Ile 
                565                 570                 575     


Thr Leu Thr Asp Glu Gly Tyr Glu His Phe Tyr Glu Val Ala Tyr Thr 
            580                 585                 590         


Val Phe Gln Tyr Leu Lys Met Leu Gln Lys Leu Gly Pro Glu Lys Arg 
        595                 600                 605             


Ile Phe Glu Glu Ile Arg Lys Ile Glu Asp Asn Glu Phe His Tyr Gln 
    610                 615                 620                 


Glu Gln Thr Asp Pro Val Glu Tyr Val Glu Asn Met Cys Glu Asn Met 
625                 630                 635                 640 


Gln Leu Tyr Pro Leu Gln Asp Ile Leu Thr Gly Asp Gln Leu Leu Phe 
                645                 650                 655     


Glu Tyr Lys Pro Glu Val Ile Gly Glu Ala Leu Asn Gln Leu Val Pro 
            660                 665                 670         


Gln Lys Ala Asn Leu Val Leu Leu Ser Gly Ala Asn Glu Gly Lys Cys 
        675                 680                 685             


Asp Leu Lys Glu Lys Trp Phe Gly Thr Gln Tyr Ser Ile Glu Asp Ile 
    690                 695                 700                 


Glu Asn Ser Trp Ala Glu Leu Trp Asn Ser Asn Phe Glu Leu Asn Pro 
705                 710                 715                 720 


Asp Leu His Leu Pro Ala Glu Asn Lys Tyr Ile Ala Thr Asp Phe Thr 
                725                 730                 735     


Leu Lys Ala Phe Asp Cys Pro Glu Thr Glu Tyr Pro Val Lys Ile Val 
            740                 745                 750         


Asn Thr Pro Gln Gly Cys Leu Trp Tyr Lys Lys Asp Asn Lys Phe Lys 
        755                 760                 765             


Ile Pro Lys Ala Tyr Ile Arg Phe His Leu Ile Ser Pro Leu Ile Gln 
    770                 775                 780                 


Lys Ser Ala Ala Asn Val Val Leu Phe Asp Ile Phe Val Asn Ile Leu 
785                 790                 795                 800 


Thr His Asn Leu Ala Glu Pro Ala Tyr Glu Ala Asp Val Ala Gln Leu 
                805                 810                 815     


Glu Tyr Lys Leu Val Ala Gly Glu His Gly Leu Ile Ile Arg Val Lys 
            820                 825                 830         


Gly Phe Asn His Lys Leu Pro Leu Leu Phe Gln Leu Ile Ile Asp Tyr 
        835                 840                 845             


Leu Ala Glu Phe Asn Ser Thr Pro Ala Val Phe Thr Met Ile Thr Glu 
    850                 855                 860                 


Gln Leu Lys Lys Thr Tyr Phe Asn Ile Leu Ile Lys Pro Glu Thr Leu 
865                 870                 875                 880 


Ala Lys Asp Val Arg Leu Leu Ile Leu Glu Tyr Ala Arg Trp Ser Met 
                885                 890                 895     


Ile Asp Lys Tyr Gln Ala Leu Met Asp Gly Leu Ser Leu Glu Ser Leu 
            900                 905                 910         


Leu Ser Phe Val Lys Glu Phe Lys Ser Gln Leu Phe Val Glu Gly Leu 
        915                 920                 925             


Val Gln Gly Asn Val Thr Ser Thr Glu Ser Met Asp Phe Leu Lys Tyr 
    930                 935                 940                 


Val Val Asp Lys Leu Asn Phe Lys Pro Leu Glu Gln Glu Met Pro Val 
945                 950                 955                 960 


Gln Phe Gln Val Val Glu Leu Pro Ser Gly His His Leu Cys Lys Val 
                965                 970                 975     


Lys Ala Leu Asn Lys Gly Asp Ala Asn Ser Glu Val Thr Val Tyr Tyr 
            980                 985                 990         


Gln Ser Gly Thr Arg Ser Leu Arg  Glu Tyr Thr Leu Met  Glu Leu Leu 
        995                 1000                 1005             


Val Met  His Met Glu Glu Pro  Cys Phe Asp Phe Leu  Arg Thr Lys 
    1010                 1015                 1020             


Gln Thr  Leu Gly Tyr His Val  Tyr Pro Thr Cys Arg  Asn Thr Ser 
    1025                 1030                 1035             


Gly Ile  Leu Gly Phe Ser Val  Thr Val Gly Thr Gln  Ala Thr Lys 
    1040                 1045                 1050             


Tyr Asn  Ser Glu Val Val Asp  Lys Lys Ile Glu Glu  Phe Leu Ser 
    1055                 1060                 1065             


Ser Phe  Glu Glu Lys Ile Glu  Asn Leu Thr Glu Glu  Ala Phe Asn 
    1070                 1075                 1080             


Thr Gln  Val Thr Ala Leu Ile  Lys Leu Lys Glu Cys  Glu Asp Thr 
    1085                 1090                 1095             


His Leu  Gly Glu Glu Val Asp  Arg Asn Trp Asn Glu  Val Val Thr 
    1100                 1105                 1110             


Gln Gln  Tyr Leu Phe Asp Arg  Leu Ala His Glu Ile  Glu Ala Leu 
    1115                 1120                 1125             


Lys Ser  Phe Ser Lys Ser Asp  Leu Val Asn Trp Phe  Lys Ala His 
    1130                 1135                 1140             


Arg Gly  Pro Gly Ser Lys Met  Leu Ser Val His Val  Val Gly Tyr 
    1145                 1150                 1155             


Gly Lys  Tyr Glu Leu Glu Glu  Asp Gly Thr Pro Ser  Ser Glu Asp 
    1160                 1165                 1170             


Ser Asn  Ser Ser Cys Glu Val  Met Gln Leu Thr Tyr  Leu Pro Thr 
    1175                 1180                 1185             


Ser Pro  Leu Leu Ala Asp Cys  Ile Ile Pro Ile Thr  Asp Ile Arg 
    1190                 1195                 1200             


Ala Phe  Thr Thr Thr Leu Asn  Leu Leu Pro Tyr His  Lys Ile Val 
    1205                 1210                 1215             


Lys 
    


<210>  6393
<211>  3802
<212>  DNA
<213>  Homosapiens

<400>  6393
gttcgctggc tgttccgaga atcagtccgg gtcacgttgg tgcctctcct ttcctgttct     60

gattggttgc ttacgtgagc gtgactactt tcttgcctca tgattggctg aaatcagtag    120

cgtcatcggc ggccgggagg gcggagggac gagggaagtc ggcgagaggg agactgggtt    180

gggggagggg ttcaggcctg ttccccgcgg ctgcggcagc accagggccg gccgccaccg    240

cctctagaac gcggaggagg tgggtcctgg gaagcgggat gtccatcgct ccagcttggt    300

ggtgaatgct gaggagagtc actgttgctg cagtctgtgc cacccggagg aagttgtgtg    360

aggccgggcg ggagctcgcg gcgctctggg gaatcgaaac gcggggtcgg tgcgaagact    420

ctgctgctgc cagacccttt cctattctgg ccatgcctgg aaggaacaag gcgaagtcta    480

cctgcagctg ccctgacctg cagcccaatg gacaggatct gggcgagaac agccgggttg    540

cccgtctagg agcggatgaa tctgaggaag agggacggag ggggtctctc agtaatgctg    600

gggaccctga gatcgtcaag tctcccagcg accccaagca ataccgatac atcaaattac    660

agaatggctt gcaggcactt ctgatttcag acctaagtaa tatggaaggt aaaacaggaa    720

atacaacaga tgatgaagaa gaagaggagg tggaggaaga agaagaagat gatgatgaag    780

attctggagc tgaaatagaa gatgacgatg aagagggttt tgatgatgaa gatgagtttg    840

atgatgaaca tgatgatgat cttgatactg aggataatga attggaagaa ttagaagaga    900

gagcagaagc tagaaaaaaa actactgaaa aacagtctgc agcggctctt tgtgttggag    960

ttgggagttt cgctgatcca gatgacctgc cggggctggc acactttttg gagcacatgg   1020

tattcatggg tagtttgaaa tatccagatg agaatggatt tgatgccttc ctgaagaagc   1080

atgggggtag tgataatgcc tcaactgatt gtgaacgcac tgtctttcag tttgatgtcc   1140

agaggaagta cttcaaggaa gctcttgata gatgggcgca gttcttcatc cacccactaa   1200

tgatcagaga tgcaattgac cgtgaagttg aagctgttga tagtgaatat caacttgcaa   1260

ggccttctga tgcaaacaga aaggaaatgt tgtttggaag ccttgctaga cctggacatc   1320

ctatgggaaa atttttttgg ggaaatgctg agacgctcaa gcatgagcca agaaagaata   1380

atattgatac acatgctaga ttgagagaat tctggatgcg ttactactct tctcattaca   1440

tgactttagt ggttcaatcc aaagaaacac tggatacttt ggaaaagtgg gtgactgaaa   1500

tcttctctca gataccaaac aatgggttac ccagaccaaa ctttggccat ttaacggatc   1560

catttgacac accagcattt aacaaacttt atagagttgt tccaatcaga aaaattcatg   1620

ctctgaccat cacatgggca cttcctcctc aacagcaaca ttacagggtg aagccacttc   1680

attatatatc ctggctggtt ggacatgaag gcaaaggcag cattctttct ttccttagga   1740

aaaaatgctg ggctcttgca ctgtttggtg gaaatggtga gacaggattt gagcaaaatt   1800

ctacttattc agtgttcagc atttctatta cattgactga tgagggttat gaacattttt   1860

atgaggttgc ttacactgtc tttcagtatt taaaaatgct gcagaagcta ggcccagaaa   1920

aaagaatttt tgaagagatt cggaaaattg aggataatga atttcattac caagaacaga   1980

cagatccagt tgagtatgtg gaaaacatgt gtgagaacat gcagctgtac ccattgcagg   2040

acattctcac tggagatcag cttctttttg aatacaagcc agaagtcatt ggtgaagcct   2100

tgaatcagct agttcctcaa aaagcaaatc ttgttttact gtctggtgct aatgagggaa   2160

aatgtgacct caaggagaaa tggtttggaa ctcaatatag tatagaagat attgaaaact   2220

cttgggctga actgtggaat agtaatttcg aattaaatcc agatcttcat cttccagctg   2280

aaaacaagta catagccacg gactttacgt tgaaggcttt cgattgcccg gaaacagaat   2340

acccagttaa aattgtgaat actccacaag gttgcctgtg gtataagaaa gacaacaaat   2400

tcaaaatccc caaagcatat atacgtttcc atctaatttc accgttgata cagaaatctg   2460

cagcaaatgt ggtcctcttt gatatctttg tcaatatcct tacgcataac cttgcggaac   2520

cagcttatga agcagatgtg gcacagctgg agtataaact ggtagctgga gaacatggtt   2580

taattattcg agtgaaagga tttaaccaca aactacctct actgtttcag ctcattattg   2640

actacttagc tgagttcaat tccacaccag ctgtctttac aatgataact gagcagttga   2700

agaagaccta ctttaacatc ctcatcaagc ccgagacttt ggccaaagat gtacggcttt   2760

taatcttgga atatgcccgt tggtctatga ttgacaagta ccaggctttg atggacggcc   2820

tttcccttga gtctctgctg agcttcgtca aagaattcaa atcccagctc tttgtggagg   2880

gcctggtaca agggaatgtc acaagcacag aatctatgga tttcctgaaa tatgttgttg   2940

acaaactaaa cttcaagcct ctggagcagg agatgcctgt gcagttccag gtggtagagc   3000

tgcccagtgg ccaccatcta tgcaaagtga aagctctgaa caagggtgat gccaactctg   3060

aagtcactgt gtactaccag tcaggtacca ggagtctaag agaatatacg cttatggagc   3120

tgcttgtgat gcacatggaa gaaccttgtt ttgacttcct tcgaaccaag cagacccttg   3180

ggtaccatgt ctaccctacc tgtaggaaca catccgggat tctaggattt tctgtcactg   3240

tggggactca ggcaaccaaa tacaattctg aagttgttga taagaagata gaagagtttc   3300

tttctagctt tgaggagaag attgagaacc tcactgaaga ggcattcaac acccaggtca   3360

cagctctcat caagctgaag gagtgtgagg atacccacct tggggaggag gtggatagga   3420

actggaatga agtggttaca cagcagtacc tctttgaccg ccttgcccac gagattgaag   3480

cactgaagtc attctcaaaa tcagacctgg tcaactggtt caaggcccat agagggccag   3540

gaagtaaaat gctcagcgtt catgttgttg gatatgggaa gtatgaactg gaagaggatg   3600

gtaccccttc tagtgaggat tcaaattctt cttgtgaagt gatgcagctg acctacctgc   3660

caacctctcc tctgctggca gattgtatca tccccattac tgatatcagg gctttcacaa   3720

caacactcaa ccttctcccc taccataaaa tagtcaaata aataaactgc agtcacgttg   3780

gcctgaagca atgtgtattt ta                                            3802


<210>  6394
<211>  1151
<212>  PRT
<213>  Homosapiens

<400>  6394

Met Leu Arg Arg Val Thr Val Ala Ala Val Cys Ala Thr Arg Arg Lys 
1               5                   10                  15      


Leu Cys Glu Ala Gly Arg Glu Leu Ala Ala Leu Trp Gly Ile Glu Thr 
            20                  25                  30          


Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg Pro Phe Pro Ile Leu 
        35                  40                  45              


Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr Cys Ser Cys Pro Asp 
    50                  55                  60                  


Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn Ser Arg Val Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg Arg Gly Ser Leu Ser 
                85                  90                  95      


Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro Ser Asp Pro Lys Gln 
            100                 105                 110         


Tyr Arg Tyr Ile Lys Leu Gln Asn Gly Leu Gln Ala Leu Leu Ile Ser 
        115                 120                 125             


Asp Leu Ser Asn Met Glu Gly Lys Thr Gly Asn Thr Thr Asp Asp Glu 
    130                 135                 140                 


Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Asp Asp Asp Glu Asp Ser 
145                 150                 155                 160 


Gly Ala Glu Ile Glu Asp Asp Asp Glu Glu Gly Phe Asp Asp Glu Asp 
                165                 170                 175     


Glu Phe Asp Asp Glu His Asp Asp Asp Leu Asp Thr Glu Asp Asn Glu 
            180                 185                 190         


Leu Glu Glu Leu Glu Glu Arg Ala Glu Ala Arg Lys Lys Thr Thr Glu 
        195                 200                 205             


Lys Gln Ser Ala Ala Ala Leu Cys Val Gly Val Gly Ser Phe Ala Asp 
    210                 215                 220                 


Pro Asp Asp Leu Pro Gly Leu Ala His Phe Leu Glu His Met Val Phe 
225                 230                 235                 240 


Met Gly Ser Leu Lys Tyr Pro Asp Glu Asn Gly Phe Asp Ala Phe Leu 
                245                 250                 255     


Lys Lys His Gly Gly Ser Asp Asn Ala Ser Thr Asp Cys Glu Arg Thr 
            260                 265                 270         


Val Phe Gln Phe Asp Val Gln Arg Lys Tyr Phe Lys Glu Ala Leu Asp 
        275                 280                 285             


Arg Trp Ala Gln Phe Phe Ile His Pro Leu Met Ile Arg Asp Ala Ile 
    290                 295                 300                 


Asp Arg Glu Val Glu Ala Val Asp Ser Glu Tyr Gln Leu Ala Arg Pro 
305                 310                 315                 320 


Ser Asp Ala Asn Arg Lys Glu Met Leu Phe Gly Ser Leu Ala Arg Pro 
                325                 330                 335     


Gly His Pro Met Gly Lys Phe Phe Trp Gly Asn Ala Glu Thr Leu Lys 
            340                 345                 350         


His Glu Pro Arg Lys Asn Asn Ile Asp Thr His Ala Arg Leu Arg Glu 
        355                 360                 365             


Phe Trp Met Arg Tyr Tyr Ser Ser His Tyr Met Thr Leu Val Val Gln 
    370                 375                 380                 


Ser Lys Glu Thr Leu Asp Thr Leu Glu Lys Trp Val Thr Glu Ile Phe 
385                 390                 395                 400 


Ser Gln Ile Pro Asn Asn Gly Leu Pro Arg Pro Asn Phe Gly His Leu 
                405                 410                 415     


Thr Asp Pro Phe Asp Thr Pro Ala Phe Asn Lys Leu Tyr Arg Val Val 
            420                 425                 430         


Pro Ile Arg Lys Ile His Ala Leu Thr Ile Thr Trp Ala Leu Pro Pro 
        435                 440                 445             


Gln Gln Gln His Tyr Arg Val Lys Pro Leu His Tyr Ile Ser Trp Leu 
    450                 455                 460                 


Val Gly His Glu Gly Lys Gly Ser Ile Leu Ser Phe Leu Arg Lys Lys 
465                 470                 475                 480 


Cys Trp Ala Leu Ala Leu Phe Gly Gly Asn Gly Glu Thr Gly Phe Glu 
                485                 490                 495     


Gln Asn Ser Thr Tyr Ser Val Phe Ser Ile Ser Ile Thr Leu Thr Asp 
            500                 505                 510         


Glu Gly Tyr Glu His Phe Tyr Glu Val Ala Tyr Thr Val Phe Gln Tyr 
        515                 520                 525             


Leu Lys Met Leu Gln Lys Leu Gly Pro Glu Lys Arg Ile Phe Glu Glu 
    530                 535                 540                 


Ile Arg Lys Ile Glu Asp Asn Glu Phe His Tyr Gln Glu Gln Thr Asp 
545                 550                 555                 560 


Pro Val Glu Tyr Val Glu Asn Met Cys Glu Asn Met Gln Leu Tyr Pro 
                565                 570                 575     


Leu Gln Asp Ile Leu Thr Gly Asp Gln Leu Leu Phe Glu Tyr Lys Pro 
            580                 585                 590         


Glu Val Ile Gly Glu Ala Leu Asn Gln Leu Val Pro Gln Lys Ala Asn 
        595                 600                 605             


Leu Val Leu Leu Ser Gly Ala Asn Glu Gly Lys Cys Asp Leu Lys Glu 
    610                 615                 620                 


Lys Trp Phe Gly Thr Gln Tyr Ser Ile Glu Asp Ile Glu Asn Ser Trp 
625                 630                 635                 640 


Ala Glu Leu Trp Asn Ser Asn Phe Glu Leu Asn Pro Asp Leu His Leu 
                645                 650                 655     


Pro Ala Glu Asn Lys Tyr Ile Ala Thr Asp Phe Thr Leu Lys Ala Phe 
            660                 665                 670         


Asp Cys Pro Glu Thr Glu Tyr Pro Val Lys Ile Val Asn Thr Pro Gln 
        675                 680                 685             


Gly Cys Leu Trp Tyr Lys Lys Asp Asn Lys Phe Lys Ile Pro Lys Ala 
    690                 695                 700                 


Tyr Ile Arg Phe His Leu Ile Ser Pro Leu Ile Gln Lys Ser Ala Ala 
705                 710                 715                 720 


Asn Val Val Leu Phe Asp Ile Phe Val Asn Ile Leu Thr His Asn Leu 
                725                 730                 735     


Ala Glu Pro Ala Tyr Glu Ala Asp Val Ala Gln Leu Glu Tyr Lys Leu 
            740                 745                 750         


Val Ala Gly Glu His Gly Leu Ile Ile Arg Val Lys Gly Phe Asn His 
        755                 760                 765             


Lys Leu Pro Leu Leu Phe Gln Leu Ile Ile Asp Tyr Leu Ala Glu Phe 
    770                 775                 780                 


Asn Ser Thr Pro Ala Val Phe Thr Met Ile Thr Glu Gln Leu Lys Lys 
785                 790                 795                 800 


Thr Tyr Phe Asn Ile Leu Ile Lys Pro Glu Thr Leu Ala Lys Asp Val 
                805                 810                 815     


Arg Leu Leu Ile Leu Glu Tyr Ala Arg Trp Ser Met Ile Asp Lys Tyr 
            820                 825                 830         


Gln Ala Leu Met Asp Gly Leu Ser Leu Glu Ser Leu Leu Ser Phe Val 
        835                 840                 845             


Lys Glu Phe Lys Ser Gln Leu Phe Val Glu Gly Leu Val Gln Gly Asn 
    850                 855                 860                 


Val Thr Ser Thr Glu Ser Met Asp Phe Leu Lys Tyr Val Val Asp Lys 
865                 870                 875                 880 


Leu Asn Phe Lys Pro Leu Glu Gln Glu Met Pro Val Gln Phe Gln Val 
                885                 890                 895     


Val Glu Leu Pro Ser Gly His His Leu Cys Lys Val Lys Ala Leu Asn 
            900                 905                 910         


Lys Gly Asp Ala Asn Ser Glu Val Thr Val Tyr Tyr Gln Ser Gly Thr 
        915                 920                 925             


Arg Ser Leu Arg Glu Tyr Thr Leu Met Glu Leu Leu Val Met His Met 
    930                 935                 940                 


Glu Glu Pro Cys Phe Asp Phe Leu Arg Thr Lys Gln Thr Leu Gly Tyr 
945                 950                 955                 960 


His Val Tyr Pro Thr Cys Arg Asn Thr Ser Gly Ile Leu Gly Phe Ser 
                965                 970                 975     


Val Thr Val Gly Thr Gln Ala Thr Lys Tyr Asn Ser Glu Val Val Asp 
            980                 985                 990         


Lys Lys Ile Glu Glu Phe Leu Ser  Ser Phe Glu Glu Lys  Ile Glu Asn 
        995                 1000                 1005             


Leu Thr  Glu Glu Ala Phe Asn  Thr Gln Val Thr Ala  Leu Ile Lys 
    1010                 1015                 1020             


Leu Lys  Glu Cys Glu Asp Thr  His Leu Gly Glu Glu  Val Asp Arg 
    1025                 1030                 1035             


Asn Trp  Asn Glu Val Val Thr  Gln Gln Tyr Leu Phe  Asp Arg Leu 
    1040                 1045                 1050             


Ala His  Glu Ile Glu Ala Leu  Lys Ser Phe Ser Lys  Ser Asp Leu 
    1055                 1060                 1065             


Val Asn  Trp Phe Lys Ala His  Arg Gly Pro Gly Ser  Lys Met Leu 
    1070                 1075                 1080             


Ser Val  His Val Val Gly Tyr  Gly Lys Tyr Glu Leu  Glu Glu Asp 
    1085                 1090                 1095             


Gly Thr  Pro Ser Ser Glu Asp  Ser Asn Ser Ser Cys  Glu Val Met 
    1100                 1105                 1110             


Gln Leu  Thr Tyr Leu Pro Thr  Ser Pro Leu Leu Ala  Asp Cys Ile 
    1115                 1120                 1125             


Ile Pro  Ile Thr Asp Ile Arg  Ala Phe Thr Thr Thr  Leu Asn Leu 
    1130                 1135                 1140             


Leu Pro  Tyr His Lys Ile Val  Lys 
    1145                 1150     


<210>  6395
<211>  792
<212>  DNA
<213>  Homosapiens

<400>  6395
gaaacactag tcctggcctg attactcgct cacttcctga gttttcagac tggcctctct     60

agcaccttag gtggccacgt gagctgggtg ctaatcctta ccacaccacc accaatttca    120

atcagagcag ctctattttt atgctatata ttgaggtcta caagattttg tggagaaaaa    180

gagttttgcc gtttaaagaa aattgaggac tctttgtctt tacggagttc attattccaa    240

gtgcatgtgt tttgacaact tctattccaa agtagtaaaa cctatgaaaa agatctggat    300

cttgtactcc agtgtgactt tggttaatac atagccccta catggtgaat taccatagga    360

catcattgct ctgtgatgta aagaggttat ttagtaagag gcttcatctt aacacatttt    420

actttcttct tgaatttctt tcctatcttc ccttcccttg taagattgaa gcactgaagt    480

cattctcaaa atcagacctg gtcaactggt tcaaggccca tagagggcca ggaagtaaaa    540

tgctcagcgt tcatgttgtt ggatatggga agtatgaact ggaagaggat ggtacccctt    600

ctagtgagga ttcaaattct tcttgtgaag tgatgcagct gacctacctg ccaacctctc    660

ctctgctggc agattgtatc atccccatta ctgatatcag ggctttcaca acaacactca    720

accttctccc ctaccataaa atagtcaaat aaataaactg cagtcacgtt ggcctgaagc    780

aatgtgtatt tt                                                        792


<210>  6396
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  6396

Met Val Asn Tyr His Arg Thr Ser Leu Leu Cys Asp Val Lys Arg Leu 
1               5                   10                  15      


Phe Ser Lys Arg Leu His Leu Asn Thr Phe Tyr Phe Leu Leu Glu Phe 
            20                  25                  30          


Leu Ser Tyr Leu Pro Phe Pro Cys Lys Ile Glu Ala Leu Lys Ser Phe 
        35                  40                  45              


Ser Lys Ser Asp Leu Val Asn Trp Phe Lys Ala His Arg Gly Pro Gly 
    50                  55                  60                  


Ser Lys Met Leu Ser Val His Val Val Gly Tyr Gly Lys Tyr Glu Leu 
65                  70                  75                  80  


Glu Glu Asp Gly Thr Pro Ser Ser Glu Asp Ser Asn Ser Ser Cys Glu 
                85                  90                  95      


Val Met Gln Leu Thr Tyr Leu Pro Thr Ser Pro Leu Leu Ala Asp Cys 
            100                 105                 110         


Ile Ile Pro Ile Thr Asp Ile Arg Ala Phe Thr Thr Thr Leu Asn Leu 
        115                 120                 125             


Leu Pro Tyr His Lys Ile Val Lys 
    130                 135     


<210>  6397
<211>  1101
<212>  DNA
<213>  Homosapiens

<400>  6397
gaaacactag tcctggcctg attactcgct cacttcctga gttttcagac tggcctctct     60

agcaccttag gtggccacgt gagctgggtg ctaatcctta ccacaccacc accaatttca    120

atcagagcag ctctattttt atgctatata ttgaggtcta caagattttg tggagaaaaa    180

gagttttgcc gtttaaagaa aattgaggac tctttgtctt tacggagttc attattccaa    240

gtgcatgtgt tttgacaact tctattccaa agtagtaaaa cctatgaaaa agatctggat    300

cttgtactcc agtgtgactt tggttaatac atagccccta catggtgaat taccatagga    360

catcattgct ctgtgatgta aagaggttat ttagtaagag gcttcatctt aacacatttt    420

agttttctta atagaagcaa ggtagatttc ctcaagccgt ggtatgcagc taccatgtaa    480

ttgggaggtg acactaaggg gatgtgggtg ttgggctcag tgtatggtat ttagctgtaa    540

ttatagcatc tgctaacctc tcttgccatt gtagatgatt ggtataaaat gtgaaggcat    600

gccagagagc ttcatcatcg ttttggtctg gaaggttagg ggtaacctga gaataggaag    660

aataaaatga ggtcttcaga tgctaagcag gtccagggac atctgcctgg gggttaggtt    720

taagagctat ctttcttctt gaatttcttt cctatcttcc cttcccttgt aagattgaag    780

cactgaagtc attctcaaaa tcagacctgg tcaactggtt caaggcccat agagggccag    840

gaagtaaaat gctcagcgtt catgttgttg gatatgggaa gtatgaactg gaagaggatg    900

gtaccccttc tagtgaggat tcaaattctt cttgtgaagt gatgcagctg acctacctgc    960

caacctctcc tctgctggca gattgtatca tccccattac tgatatcagg gctttcacaa   1020

caacactcaa ccttctcccc taccataaaa tagtcaaata aataaactgc agtcacgttg   1080

gcctgaagca atgtgtattt t                                             1101


<210>  6398
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  6398

Met Leu Ser Val His Val Val Gly Tyr Gly Lys Tyr Glu Leu Glu Glu 
1               5                   10                  15      


Asp Gly Thr Pro Ser Ser Glu Asp Ser Asn Ser Ser Cys Glu Val Met 
            20                  25                  30          


Gln Leu Thr Tyr Leu Pro Thr Ser Pro Leu Leu Ala Asp Cys Ile Ile 
        35                  40                  45              


Pro Ile Thr Asp Ile Arg Ala Phe Thr Thr Thr Leu Asn Leu Leu Pro 
    50                  55                  60                  


Tyr His Lys Ile Val Lys 
65                  70  


<210>  6399
<211>  568
<212>  DNA
<213>  Homosapiens

<400>  6399
cagaggtgat aaatccttcc tctcagggat gagttctcac tgtgttgcct ggactggtct     60

cgaaatcctg accttaagta atgcttctgc cttggcctcc caaaatgctg aaattacagg    120

cgtgagccat cattcccagc ccagcagtct tcatcttaag aagaaagctg cccagcatca    180

gaggggtcag gttcccttct aaacagaata tgataatgct ggcctgccaa aactacagct    240

tcccctttag gaaagaacta tggcaattcc agagttcaca actgcattca gacctggcct    300

acagagcatc tcacactcac tgtgcttgtg acattccctt gtaccaggcc ctccacaaag    360

agctgggatt tgaattcttt gacgaagctc agcagagact caagggaaag gccgtccatc    420

aaagcctggt acttgtcaat catagaccaa cgggcatatt ccaagattaa aagccgtaca    480

tctctgtaca gagggcagaa aaaaaacact caaagttttg ttattagaaa tgaatcttca    540

gaataaagaa atgtttggtc aaagttct                                       568


<210>  6400
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  6400

Met Ile Met Leu Ala Cys Gln Asn Tyr Ser Phe Pro Phe Arg Lys Glu 
1               5                   10                  15      


Leu Trp Gln Phe Gln Ser Ser Gln Leu His Ser Asp Leu Ala Tyr Arg 
            20                  25                  30          


Ala Ser His Thr His Cys Ala Cys Asp Ile Pro Leu Tyr Gln Ala Leu 
        35                  40                  45              


His Lys Glu Leu Gly Phe Glu Phe Phe Asp Glu Ala Gln Gln Arg Leu 
    50                  55                  60                  


Lys Gly Lys Ala Val His Gln Ser Leu Val Leu Val Asn His Arg Pro 
65                  70                  75                  80  


Thr Gly Ile Phe Gln Asp 
                85      


<210>  6401
<211>  1319
<212>  DNA
<213>  Homosapiens

<400>  6401
cctgtaatct cagctacttg ggggctgagg tgggaggatt gcttgagccc aggaagtgga     60

ggctgcagtg agctgaggtc atgccactgc cctccagcct gggcaataaa gcaagaccct    120

ggtgtttttt tttgtttgtt taaagaagtg cttaagaaat agaagatgat ggaaattcac    180

tcagtgggag tgagagagaa ggcagtctag aatgatgccc agatttcttt cttgaagcag    240

tgggttggtg gaacaggaac agtagtaaga gtgggagcat atgaggagtt tgttctgata    300

cgtatttagt tggaaatgtc tgtggggcct tgtacctgac taaggccttt tcctcagtca    360

gatgcttgtt caagattctc tccctgaact gttttgttat taaccatcct cctccatgcc    420

ttcccagttt ctcagggctg gccctttgat tggaatatat aaatggccac tcttgaaatt    480

gtggctgcta tcctcccctt tctctctatc ttcattctgc aaccccagaa ccagccttag    540

tttctgtctt ggccaccaaa agaatcttaa gtctcagtcc acaaagggaa gagaagaaat    600

aggctgcctg tttttccgag caccgttgaa gtaccaggca agggcttttg atacagagtc    660

cttagtacca tgaatttcct ccagtagaaa tcactttaga gaagagctaa tccctccatt    720

tatcccttat tttatagata agaaaacaga attcttaaga agggaagagg atgtattcac    780

tcagtattaa atgttatttt ctttgcttta tccaggttct atgtcaatgg gcccaggatt    840

ctgaaacata gtccatgttg tcataaaggc cacagcctag ttgggtaaac caacactgaa    900

caattaagtt tgatccagtt gggaaactgt attatgggta aacagattgc caagagagcc    960

agaacagtta agagctgctt agtgttccac aaacacaatc aatcttgaat cagtcaatga   1020

ataacttgcc agcatttagg tcaccaacta tatctgcttt cctaaagcta tgcagggctc   1080

cccaagcaat tggaacattg atattagctg attctgggtg aaatgaatgt ctagagagct   1140

taatgtagtt attctctttt gcctcttagg aatctatgga tttcctgaaa tatgttgttg   1200

acaaactaaa cttcaagcct ctggagcagg agatgcctgt gcagttccag gtggtagagc   1260

tgcccagtgg ccaccatcta tgcaaagtga aagctctgaa caagggtgat gccaactct    1319


<210>  6402
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  6402

Met Asp Phe Leu Lys Tyr Val Val Asp Lys Leu Asn Phe Lys Pro Leu 
1               5                   10                  15      


Glu Gln Glu Met Pro Val Gln Phe Gln Val Val Glu Leu Pro Ser Gly 
            20                  25                  30          


His His Leu Cys Lys Val Lys Ala Leu Asn Lys Gly Asp Ala Asn 
        35                  40                  45          


<210>  6403
<211>  648
<212>  DNA
<213>  Homosapiens

<400>  6403
ataatttctt cctattaatg ctctatttgg aattatgaga tctattttaa gttaaaagtg     60

aatctattaa tttccaatct gttcatagag accttagcat acagactatc aagtgacata    120

tatatacctt tttttccccc agtgttttga tgttcatctc tacagccttc caagttaaaa    180

ctatttaata cttggtctat catgctaccc aaaaacagga tcactaataa tctgagtagt    240

aaacaggaaa aagcttctta aaaatattac tcaatccaac aacttagtaa aaaactggta    300

caatctttct ttttaaaaaa taattttttc caagaagaat aactattaaa tcatatctac    360

tacttatacc tcaactcttc ccacctttaa gggtgaccac tttttttctt tttctttttt    420

tttttttttt tgagacaaag tctcactctg ttggccaggg tggagtgcag tggtgtaatc    480

aaagctcact gcaaccttaa cctccctggg ctcaggtgat cctcccatct tcagcctgtc    540

aagtagctga ggtgggagga tggcttaagc ccgggacatg gaagttgccg tgagccacgt    600

tcatgccact gcactccagc ctgggcaaca gagcaaaaac ctgtctca                 648


<210>  6404
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  6404

Pro Pro Trp Ala Gln Val Ile Leu Pro Ser Ser Ala Cys Gln Val Ala 
1               5                   10                  15      


Glu Val Gly Gly Trp Leu Lys Pro Gly Thr Trp Lys Leu Pro 
            20                  25                  30  


<210>  6405
<211>  2154
<212>  DNA
<213>  Homosapiens

<400>  6405
gttcgctggc tgttccgaga atcagtccgg gtcacgttgg tgcctctcct ttcctgttct     60

gattggttgc ttacgtgagc gtgactactt tcttgcctca tgattggctg aaatcagtag    120

cgtcatcggc ggccgggagg gcggagggac gagggaagtc ggcgagaggg agactgggtt    180

gggggagggg ttcaggcctg ttccccgcgg ctgcggcagc accagggccg gccgccaccg    240

cctctagaac gcggaggagg tgggtcctgg gaagcgggat gtccatcgct ccagcttggt    300

ggtgaatgct gaggagagtc actgttgctg cagtctgtgc cacccggagg aagttgtgtg    360

aggccgggcg ggagctcgcg gcgctctggg gaatcgaaac gcggggtcgg tgcgaagact    420

ctgctgctgc cagacccttt cctattctgg ccatgcctgg aaggaacaag gcgaagtcta    480

cctgcagctg ccctgacctg cagcccaatg gacaggatct gggcgagaac agccgggttg    540

cccgtctagg agcggatgaa tctgaggaag agggacggag ggggtctctc agtaatgctg    600

gggaccctga gatcgtcaag tctcccagcg accccaagca ataccgatac atcaaattac    660

agaatggctt gcaggcactt ctgatttcag acctaagtaa tatggaaggt aaaacaggaa    720

atacaacaga tgatgaagaa gaagaggagg tggaggaaga agaagaagat gatgatgaag    780

attctggagc tgaaatagaa gatgacgatg aagagggttt tgatgatgaa gatgagtttg    840

atgatgaaca tgatgatgat cttgatactg aggataatga attggaagaa ttagaagaga    900

gagcagaagc tagaaaaaaa actactgaaa aacaggtgcg agtcatgtct gttttcttct    960

aatttgggaa ttctttgggt aacttctaaa ctcaagcttt attttttaat ggcaaaaagg   1020

aagtatatag ttatcttttg gtcttcagta aaggtctatt ctgtatcagg attacatttt   1080

gaaaacattt tcctccaatt ataaaagtag taaatgctca ttatataaac taatggaata   1140

taaagaaaac aaaaatataa aaatcaccca tagctatatc tctcagaggt aatcaacact   1200

cagaggtatt tgaatttatg tgtatttgta tacattatat gttttaaaaa caaatactgg   1260

tagatgagga gctgcagaat tcttagcctg gattagagaa ataagagtat gttatccttg   1320

gtgagactgg aaaaagaaga agaaaagaat ggggctagtg tgaaatcttt acatgggcct   1380

agggctctaa gagttattgt atgggtggct tctatataga taattagata attgagtttg   1440

atttagcact ttatatggga acgcaaaggt ctggacaaat aagtactttg gaagagttga   1500

aatagaaact gggcagttaa gcttatttaa tatgtaacaa ccatcagtgg atagataaat   1560

aagtcttgat agggagaatt tcttaatatc ttttgaagaa tacctccatt ttcatagtag   1620

ggagtaccca gaggataatt ttcggagcca gtacagtgga attgaccagc aaaagttagt   1680

taaagctagt ttcttgaata ttgataatat attcaacatg gtacagtcta catacaaaga   1740

ggccgagatg ggcagatcac ttgagtccag gagttctgag actagcctag gtaatgtggt   1800

gaaaccctgt ctctctaaaa cattaaaaaa aattagctgg gtgtggtggc acatgcctgt   1860

ggttccagct acttgacagg ctgaagatgg gaggatcacc tgagcccagg gaggttaagg   1920

ttgcagtgag ctttgattac accactgcac tccaccctgg ccaacagagt gagactttgt   1980

ctcaaaaaaa aaaaaaaaaa gaaaaagaaa aaaagtggtc acccttaaag gtgggaagag   2040

ttgaggtata agtagtagat atgatttaat agttattctt cttggaaaaa attatttttt   2100

aaaaagaaag attgtaccag ttttttacta agttgttgga ttgagtaata tttt         2154


<210>  6406
<211>  218
<212>  PRT
<213>  Homosapiens

<400>  6406

Met Leu Arg Arg Val Thr Val Ala Ala Val Cys Ala Thr Arg Arg Lys 
1               5                   10                  15      


Leu Cys Glu Ala Gly Arg Glu Leu Ala Ala Leu Trp Gly Ile Glu Thr 
            20                  25                  30          


Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg Pro Phe Pro Ile Leu 
        35                  40                  45              


Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr Cys Ser Cys Pro Asp 
    50                  55                  60                  


Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn Ser Arg Val Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg Arg Gly Ser Leu Ser 
                85                  90                  95      


Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro Ser Asp Pro Lys Gln 
            100                 105                 110         


Tyr Arg Tyr Ile Lys Leu Gln Asn Gly Leu Gln Ala Leu Leu Ile Ser 
        115                 120                 125             


Asp Leu Ser Asn Met Glu Gly Lys Thr Gly Asn Thr Thr Asp Asp Glu 
    130                 135                 140                 


Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Asp Asp Asp Glu Asp Ser 
145                 150                 155                 160 


Gly Ala Glu Ile Glu Asp Asp Asp Glu Glu Gly Phe Asp Asp Glu Asp 
                165                 170                 175     


Glu Phe Asp Asp Glu His Asp Asp Asp Leu Asp Thr Glu Asp Asn Glu 
            180                 185                 190         


Leu Glu Glu Leu Glu Glu Arg Ala Glu Ala Arg Lys Lys Thr Thr Glu 
        195                 200                 205             


Lys Gln Val Arg Val Met Ser Val Phe Phe 
    210                 215             


<210>  6407
<211>  788
<212>  DNA
<213>  Homosapiens

<400>  6407
gttcgctggc tgttccgaga atcagtccgg gtcacgttgg tgcctctcct ttcctgttct     60

gattggttgc ttacgtgagc gtgactactt tcttgcctca tgattggctg aaatcagtag    120

cgtcatcggc ggccgggagg gcggagggac gagggaagtc ggcgagaggg agactgggtt    180

gggggagggg ttcaggcctg ttccccgcgg ctgcggcagc accagggccg gccgccaccg    240

cctctagaac gcggaggagg tgggtcctgg gaagcgggat gtccatcgct ccagcttggt    300

ggtgaatgct gaggagagtc actgttgctg cagtctgtgc cacccggagg aagttgtgtg    360

aggccgggcg ggagctcgcg gcgctctggg gaatcgaaac gcggggtcgg tgcgaagact    420

ctgctgctgc cagacccttt cctattctgg ccatgcctgg aaggaacaag gcgaagtcta    480

cctgcagctg ccctgacctg cagcccaatg gacaggatct gggcgagaac agccgggttg    540

cccgtctagg agcggatgaa tctgaggaag agggacggag ggggtctctc agtaatgctg    600

gggaccctga gatcgtcaag tctcccagcg accccaagca ataccgaact gaacttgggt    660

ctgctcgcct ggcacaataa ggacataacc acactgaggt tttgcagcag tagaaaggaa    720

ggcatttatt ttcaggatgc tacgcaaaga ggaccaggta gctaatgctt aaatcctgac    780

ctccccga                                                             788


<210>  6408
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  6408

Met Leu Arg Arg Val Thr Val Ala Ala Val Cys Ala Thr Arg Arg Lys 
1               5                   10                  15      


Leu Cys Glu Ala Gly Arg Glu Leu Ala Ala Leu Trp Gly Ile Glu Thr 
            20                  25                  30          


Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg Pro Phe Pro Ile Leu 
        35                  40                  45              


Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr Cys Ser Cys Pro Asp 
    50                  55                  60                  


Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn Ser Arg Val Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg Arg Gly Ser Leu Ser 
                85                  90                  95      


Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro Ser Asp Pro Lys Gln 
            100                 105                 110         


Tyr Arg Thr Glu Leu Gly Ser Ala Arg Leu Ala Gln 
        115                 120                 


<210>  6409
<211>  726
<212>  DNA
<213>  Homosapiens

<400>  6409
gttcgctggc tgttccgaga atcagtccgg gtcacgttgg tgcctctcct ttcctgttct     60

gattggttgc ttacgtgagc gtgactactt tcttgcctca tgattggctg aaatcagtag    120

cgtcatcggc ggccgggagg gcggagggac gagggaagtc ggcgagaggg agactgggtt    180

gggggagggg ttcaggcctg ttccccgcgg ctgcggcagc accagggccg gccgccaccg    240

cctctagaac gcggaggagg tgggtcctgg gaagcgggat gtccatcgct ccagcttggt    300

ggtgaatgct gaggagagtc actgttgctg cagtctgtgc cacccggagg aagttgtgtg    360

aggccgggcg ggagctcgcg gcgctctggg gaatcgaaac gcggggtcgg tgcgaagact    420

ctgctgctgc cagacccttt cctattctgg ccatgcctgg aaggaacaag gcgaagtcta    480

cctgcagctg ccctgacctg cagcccaatg gacaggatct gggcgagaac agccgggttg    540

cccgtctagg agcggatgaa tctgaggaag agggacggag ggggtctctc agtaatgctg    600

gggaccctga gatcgtcaag tctcccagcg accccaagca ataccgagtc tccatctgtc    660

acccatgctg gagtgccatg gcgcaatctt ggctcactgc aacctcttcc tccctggctc    720

aagtga                                                               726


<210>  6410
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  6410

Met Leu Arg Arg Val Thr Val Ala Ala Val Cys Ala Thr Arg Arg Lys 
1               5                   10                  15      


Leu Cys Glu Ala Gly Arg Glu Leu Ala Ala Leu Trp Gly Ile Glu Thr 
            20                  25                  30          


Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg Pro Phe Pro Ile Leu 
        35                  40                  45              


Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr Cys Ser Cys Pro Asp 
    50                  55                  60                  


Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn Ser Arg Val Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg Arg Gly Ser Leu Ser 
                85                  90                  95      


Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro Ser Asp Pro Lys Gln 
            100                 105                 110         


Tyr Arg Val Ser Ile Cys His Pro Cys Trp Ser Ala Met Ala Gln Ser 
        115                 120                 125             


Trp Leu Thr Ala Thr Ser Ser Ser Leu Ala Gln 
    130                 135                 


<210>  6411
<211>  863
<212>  DNA
<213>  Homosapiens

<400>  6411
gttcgctggc tgttccgaga atcagtccgg gtcacgttgg tgcctctcct ttcctgttct     60

gattggttgc ttacgtgagc gtgactactt tcttgcctca tgattggctg aaatcagtag    120

cgtcatcggc ggccgggagg gcggagggac gagggaagtc ggcgagaggg agactgggtt    180

gggggagggg ttcaggcctg ttccccgcgg ctgcggcagc accagggccg gccgccaccg    240

cctctagaac gcggaggagg tgggtcctgg gaagcgggat gtccatcgct ccagcttggt    300

ggtgaatgct gaggagagtc actgttgctg cagtctgtgc cacccggagg aagttgtgtg    360

aggccgggcg ggagctcgcg gcgctctggg gaatcgaaac gcggggtcgg tgcgaagact    420

ctgctgctgc cagacccttt cctattctgg ccatgcctgg aaggaacaag gcgaagtcta    480

cctgcagctg ccctgacctg cagcccaatg gacaggatct gggcgagaac agccgggttg    540

cccgtctagg agcggatgaa tctgaggaag agggacggag ggggtctctc agtaatgctg    600

gggaccctga gatcgtcaag tctcccagcg accccaagca ataccgagag atgatctcac    660

tgtgtcaccc aggctgtact gcagtggtgc catcatagct cactgcagca tcgaacttct    720

aggctcaagt gatcctcctg cctgtgccgc ccaaagtgtt ggaattacag gcatgagcca    780

ctgcttctag atggatgtct tttattggcg ggggggaaag ccctatatac gtatatatgt    840

attttttact aattctaaaa ctg                                            863


<210>  6412
<211>  130
<212>  PRT
<213>  Homosapiens

<400>  6412

Met Leu Arg Arg Val Thr Val Ala Ala Val Cys Ala Thr Arg Arg Lys 
1               5                   10                  15      


Leu Cys Glu Ala Gly Arg Glu Leu Ala Ala Leu Trp Gly Ile Glu Thr 
            20                  25                  30          


Arg Gly Arg Cys Glu Asp Ser Ala Ala Ala Arg Pro Phe Pro Ile Leu 
        35                  40                  45              


Ala Met Pro Gly Arg Asn Lys Ala Lys Ser Thr Cys Ser Cys Pro Asp 
    50                  55                  60                  


Leu Gln Pro Asn Gly Gln Asp Leu Gly Glu Asn Ser Arg Val Ala Arg 
65                  70                  75                  80  


Leu Gly Ala Asp Glu Ser Glu Glu Glu Gly Arg Arg Gly Ser Leu Ser 
                85                  90                  95      


Asn Ala Gly Asp Pro Glu Ile Val Lys Ser Pro Ser Asp Pro Lys Gln 
            100                 105                 110         


Tyr Arg Glu Met Ile Ser Leu Cys His Pro Gly Cys Thr Ala Val Val 
        115                 120                 125             


Pro Ser 
    130 


<210>  6413
<211>  1043
<212>  DNA
<213>  Homosapiens

<400>  6413
cttggatcac ataccaagag agtgttaaag ccacattagg attcaattcc agggccatca     60

gattccaagt ccactggaga aaagatgtat atctctaatc tgttaacaaa ttgctcaact    120

actcagacta atcccaggtg atggatgtct aatgctcagg aaaggcgagt cagtctctga    180

ggcaacagat cccatgggcc tgggtagaaa atgcccagtg cttcccagtc ccaagtgctg    240

gctttccctg tatctgcctc tgccaggcaa cacttatcag gctcccaatc agcaggagcc    300

tccatgctcc actttgaaca gcctctatgc tccagcaatg gggcatttgt gaagagtgac    360

ttgattaact tttctgacca tgggtataat acagttgctt cagagggcag tggttctggg    420

tgtgattttt acactgtaac attgtataca gtgtcatgga taattactat ttttttctgg    480

tcattaacac tcacctactc tagtactagg atttcagacc aaggtcctca tgacgcctgg    540

atattttagt atctatatcc aataatcttt tctctcctac tgaatatcca ggcaaagatg    600

aaatcgtttt ctttaaaact gtcaaattct gtaaaactca ggagccagtt caagggaaca    660

agcatcttca caatagatgg aatcaagagt taaatgttat agtggcaagc tcctgagtca    720

ctaggattgt acgtatgagc caccgcatcc agcctcaatg gcaatctctt aaaaatctaa    780

ataaatgaac ggctcagtaa cactgaggtt tacttcacac aaaaacaatc caaaccttgg    840

caagacggtg aaaccctgtc tctacaaaaa atacaaaaaa ttaactgggc aaagtagcct    900

gcacctatag tcccagctac ttgggaggct gaggtgggag gatcgattga gccctggagg    960

tcaagaatac agtgagccat agccatgatt gtacactgtg ccactccagc ctgggtgaca   1020

gagcaagacc ctgtccccct ctc                                           1043


<210>  6414
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  6414

Met Pro Ser Ala Ser Gln Ser Gln Val Leu Ala Phe Pro Val Ser Ala 
1               5                   10                  15      


Ser Ala Arg Gln His Leu Ser Gly Ser Gln Ser Ala Gly Ala Ser Met 
            20                  25                  30          


Leu His Phe Glu Gln Pro Leu Cys Ser Ser Asn Gly Ala Phe Val Lys 
        35                  40                  45              


Ser Asp Leu Ile Asn Phe Ser Asp His Gly Tyr Asn Thr Val Ala Ser 
    50                  55                  60                  


Glu Gly Ser Gly Ser Gly Cys Asp Phe Tyr Thr Val Thr Leu Tyr Thr 
65                  70                  75                  80  


Val Ser Trp Ile Ile Thr Ile Phe Phe Trp Ser Leu Thr Leu Thr Tyr 
                85                  90                  95      


Ser Ser Thr Arg Ile Ser Asp Gln Gly Pro His Asp Ala Trp Ile Phe 
            100                 105                 110         


<210>  6415
<211>  1697
<212>  DNA
<213>  Homosapiens

<400>  6415
atgcggccgg agcggagcag tgctggagcg ggagcctcag ccctcaggcg ccactgtgag     60

gacctgaccg gaccagacca tcccgcagcg ccccgccccg gccccctccg cgccctcccg    120

acgccaggtc ctgccgtccc gccgaccgtc cgggagcgaa cccgtcgtcc cgcactcgga    180

gtccgcgatg gcttcagtga cagatggtaa aactggagtc aaagatgcct ctgaccagaa    240

ttttgactac atgtttaaac tgcttatcat tggcaacagc agtgttggca agacctcctt    300

cctcttccgc tatgctgatg acacgttcac cccagccttc gttagcaccg tgggcatcga    360

cttcaaggtg aagacagtct accgtcacga gaagcgggtg aaactgcaga tctgggacac    420

agctgggcag gagcggtacc ggaccatcac aacagcctat taccgtgggg ccatgggctt    480

cattctgatg tatgacatca ccaatgaaga gtccttcaat gctgtccaag actgggctac    540

tcagatcaag acctactcct gggacaatgc acaagttatt ctggtgggga acaagtgtga    600

catggaggaa gagagggttg ttcccactga gaagggccag ctccttgcag agcagcttgg    660

gtttgatttc tttgaagcca gtgcaaagga gaacatcagt gtaaggcagg cctttgagcg    720

cctggtggat gccatttgtg acaagatgtc tgattcgctg gacacagacc cgtcgatgct    780

gggctcctcc aagaacacgc gtctctcgga caccccaccg ctgctgcagc agaactgctc    840

atgctaggca aggcccacct tcctgacctc ccctcattgt ggccccacac ccagtctgct    900

tctccctgtt acacactgtc cgctctcagc ccactctccc tgttacacac tgcccacact    960

cagagcaaga tgagttgctg ctattctttg cctgcccctg gggttctctg cagatggtcc   1020

cagtaataga tactcagcac tagactaaca taacaggtca ctacacgggt gcagaatcac   1080

tttacaaaag aagactctgt tttacgaagg ggattcacta cagggactta gagaacagtc   1140

tcttttctgc ctttaaaatg agagttcctc catttaccaa aatttgacac gcacacattc   1200

ttcaggggca tgccaattgc gtaaagtgag gctcgcctgc atagctaatc ctgttaaaga   1260

caacttctca aagcacaacg tgcttgtttc ctatcgggct ccctgcgggg ctttctctca   1320

ctacaagtca agcttgggct ctcaaagccc tgcgcctgtt accacggatg cccacagggc   1380

ctgggcagtt gctgtggcga caggaagagc taatcttcag agagctcaga ctctctaatg   1440

atgctgaagg agcaaaggct gagtcagaaa cacacttaag agaaaaggat tggccgggcg   1500

cggtggctca cgcctgtaat cccagcactt tgggaggccg aggcgggtgg atcatgaggt   1560

caggagatcg agaccatcct ggctaacaag gtgaaacccc gtctctacta aaaatacaaa   1620

aaattagccg ggcgcggtgg cgggcgcctg tagtcccagc tactcgggag gctgaggcag   1680

gagaatggcg tgaaccc                                                  1697


<210>  6416
<211>  219
<212>  PRT
<213>  Homosapiens

<400>  6416

Met Ala Ser Val Thr Asp Gly Lys Thr Gly Val Lys Asp Ala Ser Asp 
1               5                   10                  15      


Gln Asn Phe Asp Tyr Met Phe Lys Leu Leu Ile Ile Gly Asn Ser Ser 
            20                  25                  30          


Val Gly Lys Thr Ser Phe Leu Phe Arg Tyr Ala Asp Asp Thr Phe Thr 
        35                  40                  45              


Pro Ala Phe Val Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Val 
    50                  55                  60                  


Tyr Arg His Glu Lys Arg Val Lys Leu Gln Ile Trp Asp Thr Ala Gly 
65                  70                  75                  80  


Gln Glu Arg Tyr Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met 
                85                  90                  95      


Gly Phe Ile Leu Met Tyr Asp Ile Thr Asn Glu Glu Ser Phe Asn Ala 
            100                 105                 110         


Val Gln Asp Trp Ala Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala 
        115                 120                 125             


Gln Val Ile Leu Val Gly Asn Lys Cys Asp Met Glu Glu Glu Arg Val 
    130                 135                 140                 


Val Pro Thr Glu Lys Gly Gln Leu Leu Ala Glu Gln Leu Gly Phe Asp 
145                 150                 155                 160 


Phe Phe Glu Ala Ser Ala Lys Glu Asn Ile Ser Val Arg Gln Ala Phe 
                165                 170                 175     


Glu Arg Leu Val Asp Ala Ile Cys Asp Lys Met Ser Asp Ser Leu Asp 
            180                 185                 190         


Thr Asp Pro Ser Met Leu Gly Ser Ser Lys Asn Thr Arg Leu Ser Asp 
        195                 200                 205             


Thr Pro Pro Leu Leu Gln Gln Asn Cys Ser Cys 
    210                 215                 


<210>  6417
<211>  721
<212>  DNA
<213>  Homosapiens

<400>  6417
agttgttcag gggatgaagg aagctcagga aaggctgacg ggtgatgcct tcagaaagaa     60

acatcttgaa gatgaattgt aacatgaatg tgccccttct ttcatcagag ttagtgttct    120

ggaaggaaag cagcagggaa gggaatattg aggaatcatc tagaacaatt aagccgacca    180

ggaaacctca ttcctaccta cactggaagg agcgctctca ctgtggaaga gttctgctaa    240

cagaagctgg tctgcatgtt tgtggatcca gcggagagtg gcagactttc ttctcctttt    300

ccctctcacc taaatgtcaa cttgtcattg aatgtaaaga atgaaacctt ctgacacaaa    360

acttgagcca cttggatgtt tactcctcgc acttaagtat ttgagtcttt tcccatttcc    420

tcccacttta ctcaccttag tggtgaaagg agactagtag catcttttct acaaccctct    480

ttcctcttct catgcttgag cttccctgtt tgcacgcatg cgtgtgcagg actggctgtg    540

tgcttggact cggctccagg tggaagcatg ctttcccttg ttactgttgg agaaactcaa    600

accttcaagc cctaggtgta gccattttgt caagtcatca actgtatttt tgtactggca    660

ttaacaaaaa aagagataaa atattgtacc attaaacttt aataaaactt taaaaggaaa    720

t                                                                    721


<210>  6418
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  6418

Met Pro Ser Glu Arg Asn Ile Leu Lys Met Asn Cys Asn Met Asn Val 
1               5                   10                  15      


Pro Leu Leu Ser Ser Glu Leu Val Phe Trp Lys Glu Ser Ser Arg Glu 
            20                  25                  30          


Gly Asn Ile Glu Glu Ser Ser Arg Thr Ile Lys Pro Thr Arg Lys Pro 
        35                  40                  45              


His Ser Tyr Leu His Trp Lys Glu Arg Ser His Cys Gly Arg Val Leu 
    50                  55                  60                  


Leu Thr Glu Ala Gly Leu His Val Cys Gly Ser Ser Gly Glu Trp Gln 
65                  70                  75                  80  


Thr Phe Phe Ser Phe Ser Leu Ser Pro Lys Cys Gln Leu Val Ile Glu 
                85                  90                  95      


Cys Lys Glu 
            


<210>  6419
<211>  2284
<212>  DNA
<213>  Homosapiens

<400>  6419
ccgagcgttc tgttgtgtcc ctgcctacaa ttttagggaa cctaataaaa gggtggtcgg     60

tatgttttta tttgggtgtg tacttttgtt aggtcgcttt ttcgctatgc attaagtacg    120

gactttagga ctcaactagt accaggaaga aaaagaccgg acattttcac ctgtttgtta    180

tacagcgaag gggaaaaatt gggaagaaat cctcaagcta caagaaaaat aaccagaagc    240

tttacacttt agcctgcagt gacttatatc ctggtgtcct aagtccacct aagtcagttt    300

tgcaataaga ggtcccaagt ttggttttct tggagcttgc atcagttggt tgcatcatcc    360

ctgagtagaa gatttgcggt tgcaaggaaa aataaggtac agagcttctc cagcgggaaa    420

gtgcatgtct gcacggcacg agcccacgca ccgcagaaca ggcttgccag gtctcctcag    480

agaccctcgc aggaacctaa caatgaaatc cagttgtcca gtcttgattt gtggaggggt    540

aaggagaatc cgaggccagt gggcaatccg cccactgttg ggagcgactg acctcacgaa    600

tcaataattt gcttttgact aggaagtgca gcggttcttg gggggagggg ctggactggg    660

tggcggacgc gaggagcaac ggttctcccg aacctctccc ccgcccctac tatcttggcc    720

tacattttcc cgctccgtcc cgggacctgg acacccagaa tccacgaaaa gcaactcgcg    780

ctcgagaaca gctctcgtac ccttctacgt gatctgcacc tttaagctca ctccatccca    840

aaccggaccc cggaggcacc acccacatcc gtctaacatc acttccttca gagtttgaaa    900

aaaaaaaatc tgggaagtag aggtgttgtg ctgagcggcg ctcggcgaac tgtgtggacc    960

gtctgctggg actccggccc tgcgtccgct cagccccgtg gccccgcgca cctactgcca   1020

tggagacgcg gcctcgtctc ggggccacct gtttgctggg cttcagtttc ctgctcctcg   1080

tcatctcttc tgatggacat aatgggcttg gaaagggtag tggactgccc ctgatggtga   1140

ttattcataa atcctggtgt ggagcttgca aagctctaaa gcccaaattt gcagaatcta   1200

cggaaatttc agaactctcc cataattttg ttatggtaaa tcttgaggat gaagaggaac   1260

ccaaagatga agatttcagc cctgacgggg gttatattcc acgaatcctt tttctggatc   1320

ccagtggcaa ggtgcatcct gaaatcatca atgagaatgg aaaccccagc tacaagtatt   1380

tttatgtcag tgccgagcaa gttgttcagg ggatgaagga agctcaggaa aggctgacgg   1440

gtgatgcctt cagaaagaaa catcttgaag atgaattgta acatgaatgt gccccttctt   1500

tcatcagagt tagtgttctg gaaggaaagc agcagggaag ggaatattga ggaatcatct   1560

agaacaatta agccgaccag gaaacctcat tcctacctac actggaagga gcgctctcac   1620

tgtggaagag ttctgctaac agaagctggt ctgcatgttt gtggatccag cggagagtgg   1680

cagactttct tctccttttc cctctcacct aaatgtcaac ttgtcattga atgtaaagaa   1740

tgaaaccttc tgacacaaaa cttgagccac ttggatgttt actcctcgca cttaagtatt   1800

tgagtctttt cccatttcct cccactttac tcaccttagt ggtgaaagga gactagtagc   1860

atcttttcta caacgttaaa attgcagaag tagcttatca ttaaaaaaca acaacaacaa   1920

caataacaat aaatcctaag tgtaaatcag ttattctacc ccctaccaag gatatcagcc   1980

tgttttttcc cttttttctc ctgggaataa ttgtgggctt cttcccaaat ttctacagcc   2040

tctttcctct tctcatgctt gagcttccct gtttgcacgc atgcgtgtgc aggactggct   2100

gtgtgcttgg actcggctcc aggtggaagc atgctttccc ttgttactgt tggagaaact   2160

caaaccttca agccctaggt gtagccattt tgtcaagtca tcaactgtat ttttgtactg   2220

gcattaacaa aaaaagagat aaaatattgt accattaaac tttaataaaa ctttaaaagg   2280

aaat                                                                2284


<210>  6420
<211>  153
<212>  PRT
<213>  Homosapiens

<400>  6420

Met Glu Thr Arg Pro Arg Leu Gly Ala Thr Cys Leu Leu Gly Phe Ser 
1               5                   10                  15      


Phe Leu Leu Leu Val Ile Ser Ser Asp Gly His Asn Gly Leu Gly Lys 
            20                  25                  30          


Gly Ser Gly Leu Pro Leu Met Val Ile Ile His Lys Ser Trp Cys Gly 
        35                  40                  45              


Ala Cys Lys Ala Leu Lys Pro Lys Phe Ala Glu Ser Thr Glu Ile Ser 
    50                  55                  60                  


Glu Leu Ser His Asn Phe Val Met Val Asn Leu Glu Asp Glu Glu Glu 
65                  70                  75                  80  


Pro Lys Asp Glu Asp Phe Ser Pro Asp Gly Gly Tyr Ile Pro Arg Ile 
                85                  90                  95      


Leu Phe Leu Asp Pro Ser Gly Lys Val His Pro Glu Ile Ile Asn Glu 
            100                 105                 110         


Asn Gly Asn Pro Ser Tyr Lys Tyr Phe Tyr Val Ser Ala Glu Gln Val 
        115                 120                 125             


Val Gln Gly Met Lys Glu Ala Gln Glu Arg Leu Thr Gly Asp Ala Phe 
    130                 135                 140                 


Arg Lys Lys His Leu Glu Asp Glu Leu 
145                 150             


<210>  6421
<211>  2401
<212>  DNA
<213>  Homosapiens

<400>  6421
tcttagtgct agtggcggca ggtgcaggtg gccgcgcggc atcctggggc ttgcagtctc     60

ccgagcgttc tgttgtgtcc ctgcctacaa ttttagggaa cctaataaaa gggtggtcgg    120

tatgttttta tttgggtgtg tacttttgtt aggtcgcttt ttcgctatgc attaagtacg    180

gactttagga ctcaactagt accaggaaga aaaagaccgg acattttcac ctgtttgtta    240

tacagcgaag gggaaaaatt gggaagaaat cctcaagcta caagaaaaat aaccagaagc    300

tttacacttt agcctgcagt gacttatatc ctggtgtcct aagtccacct aagtcagttt    360

tgcaataaga ggtcccaagt ttggttttct tggagcttgc atcagttggt tgcatcatcc    420

ctgagtagaa gatttgcggt tgcaaggaaa aataaggtac agagcttctc cagcgggaaa    480

gtgcatgtct gcacggcacg agcccacgca ccgcagaaca ggcttgccag gtctcctcag    540

agaccctcgc aggaacctaa caatgaaatc cagttgtcca gtcttgattt gtggaggggt    600

aaggagaatc cgaggccagt gggcaatccg cccactgttg ggagcgactg acctcacgaa    660

tcaataattt gcttttgact aggaagtgca gcggttcttg gggggagggg ctggactggg    720

tggcggacgc gaggagcaac ggttctcccg aacctctccc ccgcccctac tatcttggcc    780

tacattttcc cgctccgtcc cgggacctgg acacccagaa tccacgaaaa gcaactcgcg    840

ctcgagaaca gctctcgtac ccttctacgt gatctgcacc tttaagctca ctccatccca    900

aaccggaccc cggaggcacc acccacatcc gtctaacatc acttccttca gagtttgaaa    960

aaaaaaaatc tgggaagtag aggtgttgtg ctgagcggcg ctcggcgaac tgtgtggacc   1020

gtctgctggg actccggccc tgcgtccgct cagccccgtg gccccgcgca cctactgcca   1080

tggagacgcg gcctcgtctc ggggccacct gtttgctggg cttcagtttc ctgctcctcg   1140

tcatctcttc tgatggacat aatgggcttg gaaagggttt tggagatcat attcattgga   1200

ggacactgga agatgggaag aaagaagcag ctgccagtgg actgcccctg atggtgatta   1260

ttcataaatc ctggtgtgga gcttgcaaag ctctaaagcc caaatttgca gaatctacgg   1320

aaatttcaga actctcccat aattttgtta tggtaaatct tgaggatgaa gaggaaccca   1380

aagatgaaga tttcagccct gacgggggtt atattccacg aatccttttt ctggatccca   1440

gtggcaaggt gcatcctgaa atcatcaatg agaatggaaa ccccagctac aagtattttt   1500

atgtcagtgc cgagcaagtt gttcagggga tgaaggaagc tcaggaaagg ctgacgggtg   1560

atgccttcag aaagaaacat cttgaagatg aattgtaaca tgaatgtgcc ccttctttca   1620

tcagagttag tgttctggaa ggaaagcagc agggaaggga atattgagga atcatctaga   1680

acaattaagc cgaccaggaa acctcattcc tacctacact ggaaggagcg ctctcactgt   1740

ggaagagttc tgctaacaga agctggtctg catgtttgtg gatccagcgg agagtggcag   1800

actttcttct ccttttccct ctcacctaaa tgtcaacttg tcattgaatg taaagaatga   1860

aaccttctga cacaaaactt gagccacttg gatgtttact cctcgcactt aagtatttga   1920

gtcttttccc atttcctccc actttactca ccttagtggt gaaaggagac tagtagcatc   1980

ttttctacaa cgttaaaatt gcagaagtag cttatcatta aaaaacaaca acaacaacaa   2040

taacaataaa tcctaagtgt aaatcagtta ttctaccccc taccaaggat atcagcctgt   2100

tttttccctt ttttctcctg ggaataattg tgggcttctt cccaaatttc tacagcctct   2160

ttcctcttct catgcttgag cttccctgtt tgcacgcatg cgtgtgcagg actggctgtg   2220

tgcttggact cggctccagg tggaagcatg ctttcccttg ttactgttgg agaaactcaa   2280

accttcaagc cctaggtgta gccattttgt caagtcatca actgtatttt tgtactggca   2340

ttaacaaaaa aagagataaa atattgtacc attaaacttt aataaaactt taaaaggaaa   2400

t                                                                   2401


<210>  6422
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  6422

Met Glu Thr Arg Pro Arg Leu Gly Ala Thr Cys Leu Leu Gly Phe Ser 
1               5                   10                  15      


Phe Leu Leu Leu Val Ile Ser Ser Asp Gly His Asn Gly Leu Gly Lys 
            20                  25                  30          


Gly Phe Gly Asp His Ile His Trp Arg Thr Leu Glu Asp Gly Lys Lys 
        35                  40                  45              


Glu Ala Ala Ala Ser Gly Leu Pro Leu Met Val Ile Ile His Lys Ser 
    50                  55                  60                  


Trp Cys Gly Ala Cys Lys Ala Leu Lys Pro Lys Phe Ala Glu Ser Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Leu Ser His Asn Phe Val Met Val Asn Leu Glu Asp 
                85                  90                  95      


Glu Glu Glu Pro Lys Asp Glu Asp Phe Ser Pro Asp Gly Gly Tyr Ile 
            100                 105                 110         


Pro Arg Ile Leu Phe Leu Asp Pro Ser Gly Lys Val His Pro Glu Ile 
        115                 120                 125             


Ile Asn Glu Asn Gly Asn Pro Ser Tyr Lys Tyr Phe Tyr Val Ser Ala 
    130                 135                 140                 


Glu Gln Val Val Gln Gly Met Lys Glu Ala Gln Glu Arg Leu Thr Gly 
145                 150                 155                 160 


Asp Ala Phe Arg Lys Lys His Leu Glu Asp Glu Leu 
                165                 170         


<210>  6423
<211>  653
<212>  DNA
<213>  Homosapiens

<400>  6423
aagtggggaa gccactgaat ggttttgagg agagagagga cgttatctga cttaaggttt     60

acatttaatc ttaataggat gaagaggaac ccaaagatga agatttcagc cctgacgggg    120

gttatattcc acgaatcctt tttctggatc ccagtggcaa ggtgcatcct gaaatcatca    180

atgagaatgg aaaccccagc tacaagtatt tttatgtcag tgccgagcaa ggtatagtta    240

tgctgaaggg agggaggatt attgctagat tgaactagga tgaaccacat gcaaggtctg    300

tgataggaaa gtaaattcag catgttagct gagcatctcc tgcatgtcta tagcttttgg    360

ccagatcctg tgtaggatat aggaggaaga tgagactgag ccccttccct tggaagagct    420

gactgaccca caggcagctg tgaagaactg aggcacacaa gtgactgagg tagtcacttg    480

cccatagttt catagttaag tagcagagcc agaatttgag tccagaactt agtttttttc    540

ctactgagct aatactgttt ttcctatgaa aattcagtgg aagaggaata gtgttaggtg    600

aacaagtcta agaggtttta tagatattaa acttaaatag gccgagcaca gtg           653


<210>  6424
<211>  72
<212>  PRT
<213>  Homosapiens

<400>  6424

Met Val Leu Arg Arg Glu Arg Thr Leu Ser Asp Leu Arg Phe Thr Phe 
1               5                   10                  15      


Asn Leu Asn Arg Met Lys Arg Asn Pro Lys Met Lys Ile Ser Ala Leu 
            20                  25                  30          


Thr Gly Val Ile Phe His Glu Ser Phe Phe Trp Ile Pro Val Ala Arg 
        35                  40                  45              


Cys Ile Leu Lys Ser Ser Met Arg Met Glu Thr Pro Ala Thr Ser Ile 
    50                  55                  60                  


Phe Met Ser Val Pro Ser Lys Val 
65                  70          


<210>  6425
<211>  1718
<212>  DNA
<213>  Homosapiens

<400>  6425
gcgtacaacc cggaagttgg cgcagcgcgg ttgccaatgg tcgctccctg agaggatgcc     60

gctcgtggtg ttttgcgggc tgccgtacag cggcaagagc cggcgtgctg aagagttgcg    120

cgtggcgctg gctgccgagg gccgcgcggt gtacgtggtg gacgacgcag ctgtcctggg    180

cgcagaggac ccagcggtgt acggcgattc tgcccgtgag aaggcattgc gtggagctct    240

gcgagcctcc gtggaacggc gcctgagtcg ccacgacgtg gtcatcctgg actcgcttaa    300

ctacatcaaa ggtttccgtt acgagctcta ctgcctggca cgggcggcgc gcaccccgct    360

ctgcctggtc tactgcgtac ggcccggcgg cccgatcgcg ggacctcagg tggcgggcgc    420

gaacgagaac cctggccgga acgtcagtgt gagttggcgg ccacgcgctg aggaggacgg    480

gagagcccag gcggcgggca gcagcgtcct cagggaactg catactgcgg actctgtagt    540

aaatggaagt gcccaggccg acgtacccaa ggaactggag cgagaagaat ccggggctgc    600

ggagtctcca gctcttgtga ctccggattc agagaaatct gcaaagcatg ggtccggtgc    660

cttttactct cccgaactcc tggaggccct aacgctgcgc tttgaggctc ccgattctcg    720

gaatcgctgg gaccggcctt tattcacttt ggtgggccta gaggagccgt tgcccctggc    780

ggggatccgc tctgccctgt ttgagaaccg ggccccacca ccccatcagt ctacgcagtc    840

ccagcccctc gcctccggca gctttctgca ccagttggac caggtcacga gtcaagtact    900

ggccggattg atggaagcgc agaagagcgc tgtccccggg gacttgctca cgcttcctgg    960

taccacagag cacttgcggt ttacccggcc cttgaccatg gcagaactga gtcgccttcg   1020

tcgccagttt atttcgtaca ctaaaatgca tcccaacaat gagaacttgc cgcaactggc   1080

caacatgttt cttcagtatt tgagccagag cctgcactga ccagaggagg taggggggaa   1140

gccatggctt ctgatctcca ctccacttta tttctctggg aaaaataggc tgcaggtctc   1200

cagagcatat cgatgcagta ctgtactaga gctgttgtga ctgattcact caaactttcc   1260

tgcatacccc tgtgccaggc cttgggttta cagcataagt tcagactaaa gagaatggag   1320

aactattgtg gtgcaacctg gcaaatccct cagaggacag agctaaggtg gacagggatt   1380

acctagattg gatcctactt gggctatcac agagcattga ccattggctt ccctcatctg   1440

aggcgtggga gagcagactg gatagatgag aattgtttta aaacaattgt gaacagaaac   1500

tgaagatggt acagttctac atctgcacct gccctttttt cataccacaa aagtattttt   1560

tgagtactgt actgactttt tgctagtttc tattctggga ccgagttcac agataaatcc   1620

attggtttgt atccttgaga aactttgttt ttgtggaagt aagaaagtta tctactagat   1680

tatttcctct aataaaatct tttaaaatag tctactgg                           1718


<210>  6426
<211>  354
<212>  PRT
<213>  Homosapiens

<400>  6426

Met Pro Leu Val Val Phe Cys Gly Leu Pro Tyr Ser Gly Lys Ser Arg 
1               5                   10                  15      


Arg Ala Glu Glu Leu Arg Val Ala Leu Ala Ala Glu Gly Arg Ala Val 
            20                  25                  30          


Tyr Val Val Asp Asp Ala Ala Val Leu Gly Ala Glu Asp Pro Ala Val 
        35                  40                  45              


Tyr Gly Asp Ser Ala Arg Glu Lys Ala Leu Arg Gly Ala Leu Arg Ala 
    50                  55                  60                  


Ser Val Glu Arg Arg Leu Ser Arg His Asp Val Val Ile Leu Asp Ser 
65                  70                  75                  80  


Leu Asn Tyr Ile Lys Gly Phe Arg Tyr Glu Leu Tyr Cys Leu Ala Arg 
                85                  90                  95      


Ala Ala Arg Thr Pro Leu Cys Leu Val Tyr Cys Val Arg Pro Gly Gly 
            100                 105                 110         


Pro Ile Ala Gly Pro Gln Val Ala Gly Ala Asn Glu Asn Pro Gly Arg 
        115                 120                 125             


Asn Val Ser Val Ser Trp Arg Pro Arg Ala Glu Glu Asp Gly Arg Ala 
    130                 135                 140                 


Gln Ala Ala Gly Ser Ser Val Leu Arg Glu Leu His Thr Ala Asp Ser 
145                 150                 155                 160 


Val Val Asn Gly Ser Ala Gln Ala Asp Val Pro Lys Glu Leu Glu Arg 
                165                 170                 175     


Glu Glu Ser Gly Ala Ala Glu Ser Pro Ala Leu Val Thr Pro Asp Ser 
            180                 185                 190         


Glu Lys Ser Ala Lys His Gly Ser Gly Ala Phe Tyr Ser Pro Glu Leu 
        195                 200                 205             


Leu Glu Ala Leu Thr Leu Arg Phe Glu Ala Pro Asp Ser Arg Asn Arg 
    210                 215                 220                 


Trp Asp Arg Pro Leu Phe Thr Leu Val Gly Leu Glu Glu Pro Leu Pro 
225                 230                 235                 240 


Leu Ala Gly Ile Arg Ser Ala Leu Phe Glu Asn Arg Ala Pro Pro Pro 
                245                 250                 255     


His Gln Ser Thr Gln Ser Gln Pro Leu Ala Ser Gly Ser Phe Leu His 
            260                 265                 270         


Gln Leu Asp Gln Val Thr Ser Gln Val Leu Ala Gly Leu Met Glu Ala 
        275                 280                 285             


Gln Lys Ser Ala Val Pro Gly Asp Leu Leu Thr Leu Pro Gly Thr Thr 
    290                 295                 300                 


Glu His Leu Arg Phe Thr Arg Pro Leu Thr Met Ala Glu Leu Ser Arg 
305                 310                 315                 320 


Leu Arg Arg Gln Phe Ile Ser Tyr Thr Lys Met His Pro Asn Asn Glu 
                325                 330                 335     


Asn Leu Pro Gln Leu Ala Asn Met Phe Leu Gln Tyr Leu Ser Gln Ser 
            340                 345                 350         


Leu His 
        


<210>  6427
<211>  797
<212>  DNA
<213>  Homosapiens

<400>  6427
gccgccaact cacactgacg ttccggccag ggttctcgtt cgcgcccgcc acctgaggtc     60

ccgcgatcgg gccgccgggc cgtacgcagt agaccaggca gagcggggtg cgcgccgccc    120

gtgccaggca gtagagctcg taacggaaac ctttgatgta gttaagcgag tccaggatga    180

ccacgtcgtg gcgactcagg cgccgttcca cggaggctcg cagagctcca cgcaatgcct    240

tctcacgggc agaatcgccg tacaccgctg ggtcctctgc gcccaggaca gctgcgtcgt    300

ccaccacgta caccgcgcgg ccctcggcag ccagcgccac gcgcaactct tcagcacgcc    360

ggctcttgcc gctgtacggc agcccgcaaa acaccacgag cggcatcctc tcagggagcg    420

accattggca accgcgctgc gccaacttcc gggttgtacg cgtctccgac catgggatgc    480

tgtcacttgc ctaaggctca agatttgact ctgaagagtg agtgattgag aatgaaattg    540

agaggatgcc caggagaact gcaaggtgtc taacatgatc accatcactc tattggtcaa    600

tatctaaact caggcaactg aatcctgctt tggcaagatg cccaaccaga cagtctgaag    660

ggatatacac ctacaaaaca atgaaatcct agataaaatg gactttcaga atgtgctcac    720

tagactcagt aatgacagaa ccctccataa acacaaagca agctaaaacc tatgagcaac    780

aagcaagtga ggctgcc                                                   797


<210>  6428
<211>  105
<212>  PRT
<213>  Homosapiens

<400>  6428

Met Thr Thr Ser Trp Arg Leu Arg Arg Arg Ser Thr Glu Ala Arg Arg 
1               5                   10                  15      


Ala Pro Arg Asn Ala Phe Ser Arg Ala Glu Ser Pro Tyr Thr Ala Gly 
            20                  25                  30          


Ser Ser Ala Pro Arg Thr Ala Ala Ser Ser Thr Thr Tyr Thr Ala Arg 
        35                  40                  45              


Pro Ser Ala Ala Ser Ala Thr Arg Asn Ser Ser Ala Arg Arg Leu Leu 
    50                  55                  60                  


Pro Leu Tyr Gly Ser Pro Gln Asn Thr Thr Ser Gly Ile Leu Ser Gly 
65                  70                  75                  80  


Ser Asp His Trp Gln Pro Arg Cys Ala Asn Phe Arg Val Val Arg Val 
                85                  90                  95      


Ser Asp His Gly Met Leu Ser Leu Ala 
            100                 105 


<210>  6429
<211>  2272
<212>  DNA
<213>  Homosapiens

<400>  6429
aacaagccca gaaggcggcg gacactcgca taaagtcacg cagtagtact cggagcccgg     60

ggtagaacct ggacttcaaa tctctgcact cccggccggg tggtgggcgc atatcctggg    120

tagcctctag gaagcgctag acacatggaa ccaaggcaga ttcagcctgg cagctggcaa    180

gtcatggagc actgcctgtc catctgcgag ctaacaacag tcgcgctgga agtcaacaag    240

ggaaatggaa agggagagac ccagcctcca caggggctca cgccctggga cctgtgccag    300

tgtgaacaag gttttccggc cccaggaagc aggcctaagt actctcattt catcactgag    360

gagcctgaga cgttcagtca ttgattggac agccctcacc attcaagccc tccttggttt    420

acagcagcag aaagagaggc tctgaaggtt ctagccagag gaagctgcag ccaggcctgg    480

cagtctcccc tgctcccttc caccagcttg gttcctgttt ctgctggtcc tgggagcccc    540

cagcagatgg actgccctta tcagccggct ccaggccaga ggaggaatcc tccggtcacg    600

tgtggctctc tggagggaga gagacctcat aaatacatac agcccacgca gaggaagggg    660

ggagggtcaa ggggaaagaa accttgacat tctggcgact gggccaggat taaagtccac    720

caggcatagt ccttattggc tatttctatg aggaatctca aatccacatg gcttccctgg    780

atgacaacgc tgactttgac tagccctggg atctggggca ttcccagtgt gctgctggct    840

tgatccaggc ctaatccttt gcccaggact gacctttcac agtttacaga gcactttatc    900

tcctggctca gtgaagtctc acagaaccct ccagagagaa gggagtttat catcaccctc    960

aatttacaga tgaggaagct gaggctgcga ttgtaactga ctccatgccc cgggcgagcc   1020

atcgttcctg cctggcgaag tccacaatcc aataaggagg gaaggttgaa gggatgaatc   1080

tcaacagaat tgtgcacagt gaaagaagcc aatgaaagaa gagtacatat tgtataattc   1140

catttataga aaactctaga aaatgcaagc tgatctacag tgacagaaag cagatccatg   1200

gttgtttggg gaagtgaggc agaaggaaag gattcagaga agcacaagga accttttagg   1260

gtggtagaca tgcttactat ctggtactga gagtttctca tgtctgcacg tatctaattg   1320

tacactttaa atacacacag tttattgtat gtcaattata tctccataaa gctatttaaa   1380

aagaggaacg taagtgggga aaagaatgaa ggaagttggc tggcgtataa ttaagtaagt   1440

ctgtgagcag tcttaaagtg gggacacaaa gtaccatggg cacgtaagag aagaaggtag   1500

agattcattc ccaaacggaa gagatcagga aggagttctt agaacagggt ttcaacaaag   1560

ctcaaggtat ggataagtaa gggtcaggtt aagaaagatt cagatggaag atacagatag   1620

agtttatttg ggaaatagag agtggagtat tatacacacg cacaattcgc ctttttaccc   1680

aagttttgaa ggactgaagt taaaactaac agcaactatc ctctcttttc ttcagaaatt   1740

cagacacatg ccctacttgg caggcagcta gttttgctaa taagattcct gcccttctcc   1800

ctccctctct gtgcatctca tcccttcggt cccgctgagg cccctaccct ctcggatttc   1860

ctctttgaac tgaactgcca aatacttgcc agcttccagg gccctgagta cccacatttc   1920

agcctcttcc aaaccccaga gtaagaagga gatttgggga gttctgggtg ggcatgtgat   1980

gggagactag gtccaacata aaaagatatt tccctttttc ttccatactt tttggcttag   2040

taattgacat gtgaccattg gagaattttg aatagtttat tagaatacat tgtgatagag   2100

aagaaggaaa ttcaagaatt gttacaatgt tgtacactga ttaactggct aatttgctgc   2160

aaaaccaatt ctgatcactg ctcttatggt ttgtaataca ttattttggg tttggatgat   2220

cctgttattc atagctttac ataaagaaat attccaatga catatgaaac cc           2272


<210>  6430
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  6430

Met Glu Pro Arg Gln Ile Gln Pro Gly Ser Trp Gln Val Met Glu His 
1               5                   10                  15      


Cys Leu Ser Ile Cys Glu Leu Thr Thr Val Ala Leu Glu Val Asn Lys 
            20                  25                  30          


Gly Asn Gly Lys Gly Glu Thr Gln Pro Pro Gln Gly Leu Thr Pro Trp 
        35                  40                  45              


Asp Leu Cys Gln Cys Glu Gln Gly Phe Pro Ala Pro Gly Ser Arg Pro 
    50                  55                  60                  


Lys Tyr Ser His Phe Ile Thr Glu Glu Pro Glu Thr Phe Ser His 
65                  70                  75                  


<210>  6431
<211>  394
<212>  DNA
<213>  Homosapiens

<400>  6431
cctaagaaga tgtagataaa gtgactgcaa ggacctccgc tgacctgagc acttcctgca     60

tgaaaggggc tcaataccaa ggaagaaaac agatacatgc accctttcta agtagcaaaa    120

ctgggttcaa atcctcggct acatcactta tgtgagatga agtcccacta tattgccaag    180

gctggacttg aatccctaag ctcaagtagt gttcccacct caccctccca agtaactgag    240

actacaggtg cacaccactg taccagcata attgcatatc ttatcaatca atccacagcc    300

actaaatacc tactgaggta tctgtgtccc ctgggctttt tccaagagct ttcaatatgg    360

ttagatttgt ttattaaatt tgcataaata tgtg                                394


<210>  6432
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  6432

Met Lys Ser His Tyr Ile Ala Lys Ala Gly Leu Glu Ser Leu Ser Ser 
1               5                   10                  15      


Ser Ser Val Pro Thr Ser Pro Ser Gln Val Thr Glu Thr Thr Gly Ala 
            20                  25                  30          


His His Cys Thr Ser Ile Ile Ala Tyr Leu Ile Asn Gln Ser Thr Ala 
        35                  40                  45              


Thr Lys Tyr Leu Leu Arg Tyr Leu Cys Pro Leu Gly Phe Phe Gln Glu 
    50                  55                  60                  


Leu Ser Ile Trp Leu Asp Leu Phe Ile Lys Phe Ala 
65                  70                  75      


<210>  6433
<211>  998
<212>  DNA
<213>  Homosapiens

<400>  6433
ccatcttcac cccaagccca ctggctcctg agatacgaca tccagaccca gtgcagctgg     60

acctggccca ggaagatcat gcggtttctg ggaagcactg gagaaggaaa aggctgaaga    120

aaggaagacc ggaaaagaaa tacaagtcct tccgccttgg caaagatgat agtaccgttc    180

ccttcagtgt tccggttctg ctctattgga taagttccgg tttgactatg actacgtgaa    240

aatgtggaac cagaccttca ccccacattc cagctccagc tctaccacag aggaagtgca    300

atatcacctt agttattcaa cacattatgc tcctcgtgat acaaccagag ttcacatcag    360

caatcttggc agctctcacc acgctgctga ctcacgactc tctcatgtcc caatttcctg    420

tccattgttc tttcctctac ttggcctgat ttctaaaggc ctctcttggt tgcattaagc    480

gggattcctg agggattccc ttggcagtta ccttggggga gctcttaggt ttggggctga    540

tccatgtcct ctaaatgtag gacttcaaag ctcccaaaga taggcaggcc cagtgggaag    600

ctgggaaatg ctctctgacc cctctgggag ggctggcagt cagagggcct tttggaaaga    660

gtcagacctg atccataagt ccctggaaaa caccctgccc agggagcaaa tgccactgtg    720

gccttgactg aggcttcaga agagtttggg agctgcaatt catccacaca cgcattcatt    780

ttcaagtagt ggtttgcagt tcaggctttg gagccacata agcctggctt caaagccact    840

ttccagcttt gtaggaagtc tctacatttt taaacctcca tttttttttc ctgtaaaact    900

ggggtcttca tggtacttaa cttcatcgtg atgttgagag aatgaaaaga aaaaggataa    960

ataaatggct tagcctcgtg ccttggcaca tattgtga                            998


<210>  6434
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  6434

Met Trp Asn Gln Thr Phe Thr Pro His Ser Ser Ser Ser Ser Thr Thr 
1               5                   10                  15      


Glu Glu Val Gln Tyr His Leu Ser Tyr Ser Thr His Tyr Ala Pro Arg 
            20                  25                  30          


Asp Thr Thr Arg Val His Ile Ser Asn Leu Gly Ser Ser His His Ala 
        35                  40                  45              


Ala Asp Ser Arg Leu Ser His Val Pro Ile Ser Cys Pro Leu Phe Phe 
    50                  55                  60                  


Pro Leu Leu Gly Leu Ile Ser Lys Gly Leu Ser Trp Leu His 
65                  70                  75              


<210>  6435
<211>  220
<212>  DNA
<213>  Homosapiens

<400>  6435
aaaactgtag cccagggcat tgaaaacctc tcggagaggg ccaggtgtga ccagccctgt     60

gcccatcctg ctgtgattca ggagtctcgc agaagacatc agaatgcctt tctctgagtc    120

acagtctgta tcttctagaa aaggctgtcc atcttcaccc caagcccact ggctcctgag    180

atacgacatc cagacccagt gcagctggac ctggcccagg                          220


<210>  6436
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  6436

Met Pro Phe Ser Glu Ser Gln Ser Val Ser Ser Arg Lys Gly Cys Pro 
1               5                   10                  15      


Ser Ser Pro Gln Ala His Trp Leu Leu Arg Tyr Asp Ile Gln Thr Gln 
            20                  25                  30          


Cys Ser Trp Thr Trp Pro 
        35              


<210>  6437
<211>  485
<212>  DNA
<213>  Homosapiens

<400>  6437
ttccaccagg tgataagcat gatcatgcct ttgctttaca aagattccct tggtgatgat     60

gcagaggagg atggaggggt atcatggaga cagacgagtc cttttggagg ctgttgcaat    120

aatccaggca aaagatgtca agggcctgca attgtgtcca agcacagtgg atacgttgat    180

agaaatatga tgcttctact ttaatcagac tttctgatgt ttctcttttt cccttgtctg    240

ttttgaaact tctagttttt cagtgtaaca ccagagctgt agagggagaa gggccactag    300

gagattccat ttcagtgatg tagccagcag gaaagccccc ataagtgaga gcctggagaa    360

gtatctccta ccctggactg tggcaggagg gaaaaagagc agtcactgta gggtgaatag    420

agtggtcctt agatttagtg ttttacttcc cctcccagcc ttgagccagc tgctgtgact    480

catgg                                                                485


<210>  6438
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  6438

Met Ile Met Pro Leu Leu Tyr Lys Asp Ser Leu Gly Asp Asp Ala Glu 
1               5                   10                  15      


Glu Asp Gly Gly Val Ser Trp Arg Gln Thr Ser Pro Phe Gly Gly Cys 
            20                  25                  30          


Cys Asn Asn Pro Gly Lys Arg Cys Gln Gly Pro Ala Ile Val Ser Lys 
        35                  40                  45              


His Ser Gly Tyr Val Asp Arg Asn Met Met Leu Leu Leu 
    50                  55                  60      


<210>  6439
<211>  436
<212>  DNA
<213>  Homosapiens

<400>  6439
aacgatgtgg tgcctgctct ggggagtgga gagtctctga agggtttcca ccaggtgata     60

agcatgatca tgcctttgct ttacaaagat tcccttggtg atgatgcaga ggaggatgga    120

ggggtatcat ggagacagac gagtcctttt ggaggctgtt gcaataatcc aggcaaaaga    180

tgtcaagggc ctgcaattgt gtccaagcac agtggatacg ttgatagaaa tatgatgctt    240

ctactttaat cagactttct gatgtttctc tttttccctt gtctgttttg aaacttctag    300

tttttcagtg taacaccaga gctgtagagg gagaagggcc actaggagat tccatttcag    360

tgatgtagcc agcaggaaag cccccataag tgagagcctg gagaagtatc tcctaccctg    420

gactgtggca ggaggg                                                    436


<210>  6440
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  6440

Met Ile Met Pro Leu Leu Tyr Lys Asp Ser Leu Gly Asp Asp Ala Glu 
1               5                   10                  15      


Glu Asp Gly Gly Val Ser Trp Arg Gln Thr Ser Pro Phe Gly Gly Cys 
            20                  25                  30          


Cys Asn Asn Pro Gly Lys Arg Cys Gln Gly Pro Ala Ile Val Ser Lys 
        35                  40                  45              


His Ser Gly Tyr Val Asp Arg Asn Met Met Leu Leu Leu 
    50                  55                  60      


<210>  6441
<211>  306
<212>  DNA
<213>  Homosapiens

<400>  6441
cctgtagtct cagctattcg ggaggctgag gcaggaggat tgcttgatga gcccaggatg     60

tcaagtctgc agagagtcat gattgcacga ttgtattcag cctgggcaac accgtgagac    120

tcatcagatg tcatagtagt cattcccttg ggttttcctg ccggtgaata ttacagagtc    180

caagcacagt ggatacgttg atagaaatat gatgcttcta ctttaatcag actttctgat    240

gtttctcttt ttcccttgtc tgttttgaaa cttctagttt ttcagtgtaa caccagagct    300

gtagag                                                               306


<210>  6442
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  6442

Ala Gln Asp Val Lys Ser Ala Glu Ser His Asp Cys Thr Ile Val Phe 
1               5                   10                  15      


Ser Leu Gly Asn Thr Val Arg Leu Ile Arg Cys His Ser Ser His Ser 
            20                  25                  30          


Leu Gly Phe Ser Cys Arg 
        35              


<210>  6443
<211>  316
<212>  DNA
<213>  Homosapiens

<400>  6443
agcctgtggg aaaatgactg agtgcccata gatgaagtgc tttcaagact gtctggcacc     60

tagaggtatc atcgcagaag ccttggatat gaacagaagc aggcagagga tgaagctgat    120

ggtgtgcatg gtcactgtgc tcctgcccat ttttgagctt ctggaataca agctgtgcct    180

ttgcctggaa tgtccctccc agtctgacta ggcatcttct gatggggttt gacctggttg    240

cttctaacac taggatggac ctcttggcaa tctctggata tctttctgtg gtttgttata    300

atggtaatta ttactt                                                    316


<210>  6444
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  6444

Met Lys Cys Phe Gln Asp Cys Leu Ala Pro Arg Gly Ile Ile Ala Glu 
1               5                   10                  15      


Ala Leu Asp Met Asn Arg Ser Arg Gln Arg Met Lys Leu Met Val Cys 
            20                  25                  30          


Met Val Thr Val Leu Leu Pro Ile Phe Glu Leu Leu Glu Tyr Lys Leu 
        35                  40                  45              


Cys Leu Cys Leu Glu Cys Pro Ser Gln Ser Asp 
    50                  55                  


<210>  6445
<211>  623
<212>  DNA
<213>  Homosapiens

<400>  6445
agaacaatgc gggagttgca gagagaggtg tcctgtgttt gttcccagtc ttccttcact     60

cacctgcacc tgctcctgcc ctgcttcggc caacatgttc tatgcaggca gcagagttca    120

tatcaagggc ccatgtttta actgaatata atgaattttt tttttcacct tggaagagtc    180

ttagaggcaa gattagaatg ttcatctaaa aggagtgcaa atttcttcaa ccattcccac    240

ggaggaaggt ctactctgtg aaaaggaaat gatcatacat aattcatgca tttgctgtac    300

ggatttaatt aaatgataga caaaaagtag agtggcacaa gtcaaactca aaaaatagta    360

acaacaaaat caatttcaaa ataagcaaca gcaataaatg ttacctacta ttttacgaat    420

gaaaatactg agaccaataa aggcattata gtatacatag ccttggaatc agaagaccaa    480

gaacatacaa gagaacatag ccttggaatc agaagaccaa gaaacaattt aactctgccc    540

ctctagagct ctgagaactt gggcaagcct tttaccctct gtgagtttca gtttcctcat    600

ttatttaatt gaaataataa tac                                            623


<210>  6446
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  6446

Met Arg Glu Leu Gln Arg Glu Val Ser Cys Val Cys Ser Gln Ser Ser 
1               5                   10                  15      


Phe Thr His Leu His Leu Leu Leu Pro Cys Phe Gly Gln His Val Leu 
            20                  25                  30          


Cys Arg Gln Gln Ser Ser Tyr Gln Gly Pro Met Phe 
        35                  40                  


<210>  6447
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  6447
ctacagttac taagcgccca ctgtgtgccc tggaagggac tagactcagc aggaaaaaca     60

tccaggcaag tggacagcat ttgcaacagc ccagcaataa gaaggaccat attctacttg    120

ggaaaaggta aagtcgtttc atatggacgg agcctgccag gaaacctgtc attcaaccct    180

ttgcaataaa acagctcctc atgaatgaag caaaataaat cagaagttgt gggcttttaa    240

actcactaaa tgaaagcaca gcatgcatgc agcctccctc caaattaatc accagattaa    300

atgcaagatg tgcacaccaa atcaatagct tgtgacgggg acctcctgcc tgtgcttcag    360

gaaaattcca tttcctttca gatgttgtcg cttgaaatgt caggaagttt ccattcatca    420

cccgcccttg aaaatgccac catcaccata cttcatgttt ccttgctttc tttcttcaga    480

ggaatccaag caccttgcag agggagccca ctccttgtca cagactctcc tggaggctga    540

aacaggggca gtctgcacag aggagaggtg tagagaggcg cgatttagaa ataagaaaac    600

caaatcgtaa agaagcctaa tgtcttgttg caacatctga aagaaacaag atgaatatat    660

tccactaggt gggaagctta gggtagtggg aagaacatgg attcaggact ttgagaaaca    720

tggatttaaa ttttgatccc caatgcctct ctgcacttca ctgttatcta taaaatagag    780

gaaataaaaa tactatacat tcaagtctta acaccaacag ttaactagtt gtgtaacctt    840

ggacaagtta tgtgacctct ctgtctgagc attgtcattt gtatatgaga tcatggaggt    900

taaatgtcca acctgttgtc actgtgcacc tcaaaataat aaataaaaca tttcatctct    960

caa                                                                  963


<210>  6448
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  6448

Met Gln Asp Val His Thr Lys Ser Ile Ala Cys Asp Gly Asp Leu Leu 
1               5                   10                  15      


Pro Val Leu Gln Glu Asn Ser Ile Ser Phe Gln Met Leu Ser Leu Glu 
            20                  25                  30          


Met Ser Gly Ser Phe His Ser Ser Pro Ala Leu Glu Asn Ala Thr Ile 
        35                  40                  45              


Thr Ile Leu His Val Ser Leu Leu Ser Phe Phe Arg Gly Ile Gln Ala 
    50                  55                  60                  


Pro Cys Arg Gly Ser Pro Leu Leu Val Thr Asp Ser Pro Gly Gly 
65                  70                  75                  


<210>  6449
<211>  656
<212>  DNA
<213>  Homosapiens

<400>  6449
gtccaggtgc tctcctgccg ccaacacagc cctaatgagc tctgcatatt caaaacacaa     60

gtaattgata gtccaattta aagtgtgcag aggccaaatt tctttccaga cgctgaagga    120

aaaacaccag ctgaggaaga atgaagaact gcctgttcta agttattctc cttctgtggt    180

cattcgagca ccaggaagac caggtttgcc ccatcaagta cctcaagaaa gaagtcaatt    240

acctaaagaa gtcaagcaaa gaggaaagga caaaatgaaa atcatgtacc agggtacacg    300

tcgaggctcc aagctggaat gaatatggcc ttcaacatac tctttatcat acagaagctt    360

gtgttcaggg cttggatttt gaagtcagac agacctggat taaaaaccaa ttcaactacc    420

tattacatat gtgacctagg aaaaacatcc aggcaagtgg acagcatttg caacagccca    480

gcaataagaa ggaccatatt ctacttggga aaaggtaaag tcgtttcata tggacggagc    540

ctgccaggaa acctgtcatt caaccctttg caataaaaca gctcctcatg aatgaagcaa    600

aataaatcag aagttgtggg cttttaaact cactaaatga aagcacagca tgcatg        656


<210>  6450
<211>  85
<212>  PRT
<213>  Homosapiens

<400>  6450

Met Asn Met Ala Phe Asn Ile Leu Phe Ile Ile Gln Lys Leu Val Phe 
1               5                   10                  15      


Arg Ala Trp Ile Leu Lys Ser Asp Arg Pro Gly Leu Lys Thr Asn Ser 
            20                  25                  30          


Thr Thr Tyr Tyr Ile Cys Asp Leu Gly Lys Thr Ser Arg Gln Val Asp 
        35                  40                  45              


Ser Ile Cys Asn Ser Pro Ala Ile Arg Arg Thr Ile Phe Tyr Leu Gly 
    50                  55                  60                  


Lys Gly Lys Val Val Ser Tyr Gly Arg Ser Leu Pro Gly Asn Leu Ser 
65                  70                  75                  80  


Phe Asn Pro Leu Gln 
                85  


<210>  6451
<211>  2058
<212>  DNA
<213>  Homosapiens

<400>  6451
cccagaaaga ggcttctcca acccggcccg gcccttcctt cccctttccc gcagtcgttg     60

cctcctcctc ccctgcctcc tcctcccctt cctcctcctg gccgcttagt ctcacacccg    120

ccgggccgtt gttcccgaga cgttgttgag tcccctgtgt cctcttctgg gtggaggaac    180

tgcaatgtct ggtggagaac agaaaccaga gaggtactat gtgggtgtgg acgttggaac    240

aggcagtgtc cgtgcagctc tggtggacca gagtggggtc ctgttggctt ttgcagacca    300

gccaattaag aattgggagc cccagttcaa ccaccatgag cagtcctccg aggacatctg    360

ggctgcgtgc tgtgttgtca caaagaaagt tgtacaaggg attgatttaa accaaattcg    420

aggacttggg tttgatgcca cgtgttctct ggttgttttg gataagcagt ttcacccatt    480

accagtcaac caggaagggg attcccatcg aaacgtcatc atgtggctgg accatcgagc    540

agtcagtcaa gttaacagga tcaatgagac caagcacagt gtcctccagt acgtcggggg    600

ggtgatgtct gtggaaatgc aggccccgaa acttctgtgg ctgaaagaga acttgagaga    660

gatttgctgg gataaggcgg gacatttctt tgatctcccg gacttcttat cgtggaaggc    720

aacaggtgtc acagcacggt ctctctgctc cctggtgtgt aagtggacat attcagcaga    780

gaaaggctgg gacgacagtt tctggaaaat gattggtttg gaagactttg ttgcagataa    840

ttacagcaaa ataggaaacc aagtgctacc tcctggagct tctcttggaa atgggctcac    900

accagaggca gcaagagacc ttggccttct ccctgggatt gcggtcgcag cttcactcat    960

tgatgcccat gcaggaggac taggagtgat tggggcagat gtgagagggc acggcctcat   1020

ctgtgagggg cagccagtga cgtcacggct ggctgtcatc tgtggaacgt cttcttgtca   1080

catggggatc agcaaagacc cgatttttgt accaggcgtc tgggggcctt atttctcagc   1140

catggtacct gggttctggc tgaatgaagg tggtcagagc gttactggaa aattgataga   1200

ccacatggta caaggccatg ctgcttttcc agaactacaa gtaaaggcca cagccagatg   1260

ccagagtata tatgcatatt tgaacagtca cctggatctg attaagaagg ctcagcctgt   1320

gggtttcctt actgttgatt tacatgtttg gccagatttc catggcaacc ggtctccctt   1380

agcagatctg acactaaagg gcatgagaac cactggatat ctgtatattc cggctttggc   1440

agcgttgcac tctcccagtt ctctactctc ccctcaggtc accggattga aactgtctca   1500

ggaccttgat gatcttgcca ttctctacct ggccacagtt caagccattg ctttggggac   1560

tcgcttcatt atagaagcca tggaggcagc agggcactca atcagtactc ttttcctatg   1620

tggaggcctc agcaagaatc ccctttttgt gcaaatgcat gcggacatta ctggcatgcc   1680

tgtggtcctg tcgcaagagg tggagtccgt tcttgtgggt gctgctgttc tgggtgcctg   1740

tgcctcaggg gatttcgctt ctgtacagga agcaatggca aaaatgagca aagttgggaa   1800

agttgtgttc ccgagactac aggataaaaa atactatgat aagaaatacc aagtattcct   1860

gaagctggtt gaacaccaga aggagtattt ggcgatcatg aatgatgact gaacagggct   1920

tgcaggtgct gatgccagaa gcttctgtgc cattgcatta aagacttgtc atttgatcca   1980

tgttcaagac ccttgaggta ttgtttcatc atttctgtat tgtctttcaa taaagaaaac   2040

aaacatgtgc aaccagaa                                                 2058


<210>  6452
<211>  575
<212>  PRT
<213>  Homosapiens

<400>  6452

Met Ser Gly Gly Glu Gln Lys Pro Glu Arg Tyr Tyr Val Gly Val Asp 
1               5                   10                  15      


Val Gly Thr Gly Ser Val Arg Ala Ala Leu Val Asp Gln Ser Gly Val 
            20                  25                  30          


Leu Leu Ala Phe Ala Asp Gln Pro Ile Lys Asn Trp Glu Pro Gln Phe 
        35                  40                  45              


Asn His His Glu Gln Ser Ser Glu Asp Ile Trp Ala Ala Cys Cys Val 
    50                  55                  60                  


Val Thr Lys Lys Val Val Gln Gly Ile Asp Leu Asn Gln Ile Arg Gly 
65                  70                  75                  80  


Leu Gly Phe Asp Ala Thr Cys Ser Leu Val Val Leu Asp Lys Gln Phe 
                85                  90                  95      


His Pro Leu Pro Val Asn Gln Glu Gly Asp Ser His Arg Asn Val Ile 
            100                 105                 110         


Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu 
        115                 120                 125             


Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu 
    130                 135                 140                 


Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile 
145                 150                 155                 160 


Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser 
                165                 170                 175     


Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys 
            180                 185                 190         


Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys 
        195                 200                 205             


Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly 
    210                 215                 220                 


Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro 
225                 230                 235                 240 


Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala 
                245                 250                 255     


Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp 
            260                 265                 270         


Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg 
        275                 280                 285             


Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys 
    290                 295                 300                 


Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met 
305                 310                 315                 320 


Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys 
                325                 330                 335     


Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln 
            340                 345                 350         


Val Lys Ala Thr Ala Arg Cys Gln Ser Ile Tyr Ala Tyr Leu Asn Ser 
        355                 360                 365             


His Leu Asp Leu Ile Lys Lys Ala Gln Pro Val Gly Phe Leu Thr Val 
    370                 375                 380                 


Asp Leu His Val Trp Pro Asp Phe His Gly Asn Arg Ser Pro Leu Ala 
385                 390                 395                 400 


Asp Leu Thr Leu Lys Gly Met Arg Thr Thr Gly Tyr Leu Tyr Ile Pro 
                405                 410                 415     


Ala Leu Ala Ala Leu His Ser Pro Ser Ser Leu Leu Ser Pro Gln Val 
            420                 425                 430         


Thr Gly Leu Lys Leu Ser Gln Asp Leu Asp Asp Leu Ala Ile Leu Tyr 
        435                 440                 445             


Leu Ala Thr Val Gln Ala Ile Ala Leu Gly Thr Arg Phe Ile Ile Glu 
    450                 455                 460                 


Ala Met Glu Ala Ala Gly His Ser Ile Ser Thr Leu Phe Leu Cys Gly 
465                 470                 475                 480 


Gly Leu Ser Lys Asn Pro Leu Phe Val Gln Met His Ala Asp Ile Thr 
                485                 490                 495     


Gly Met Pro Val Val Leu Ser Gln Glu Val Glu Ser Val Leu Val Gly 
            500                 505                 510         


Ala Ala Val Leu Gly Ala Cys Ala Ser Gly Asp Phe Ala Ser Val Gln 
        515                 520                 525             


Glu Ala Met Ala Lys Met Ser Lys Val Gly Lys Val Val Phe Pro Arg 
    530                 535                 540                 


Leu Gln Asp Lys Lys Tyr Tyr Asp Lys Lys Tyr Gln Val Phe Leu Lys 
545                 550                 555                 560 


Leu Val Glu His Gln Lys Glu Tyr Leu Ala Ile Met Asn Asp Asp 
                565                 570                 575 


<210>  6453
<211>  1947
<212>  DNA
<213>  Homosapiens

<400>  6453
agaaagaggc ttctccaacc cggcccggcc cttccttccc ctttcccgca gtcgttgcct     60

cctcctcccc tgcctcctcc tccccttcct cctcctggcc gcttagtctc acacccgccg    120

ggccgttgtt cccgagacgt tgttgagtcc cctgtgtcct cttctgggtg gaggaactgc    180

aatgtctggt ggagaacaga aaccagagag gtactatgtg ggtgtggacg ttggaacagg    240

cagtgtccgt gcagctctgg tggaccagag tggggtcctg ttggcttttg cagaccagcc    300

aattaagaat tgggagcccc agttcaacca ccatgagcag tcctccgagg acatctgggc    360

tgcgtgctgt gttgtcacaa aggggattcc catcgaaacg tcatcatgtg gctggaccat    420

cgagcagtca gtcaagttaa caggatcaat gagaccaagc acagtgtcct ccagtacgtc    480

gggggggtga tgtctgtgga aatgcaggcc ccgaaacttc tgtggctgaa agagaacttg    540

agagagattt gctgggataa ggcgggacat ttctttgatc tcccggactt cttatcgtgg    600

aaggcaacag gtgtcacagc acggtctctc tgctccctgg tgtgtaagtg gacatattca    660

gcagagaaag gctgggacga cagtttctgg aaaatgattg gtttggaaga ctttgttgca    720

gataattaca gcaaaatagg aaaccaagtg ctacctcctg gagcttctct tggaaatggg    780

ctcacaccag aggcagcaag agaccttggc cttctccctg ggattgcggt cgcagcttca    840

ctcattgatg cccatgcagg aggactagga gtgattgggg cagatgtgag agggcacggc    900

ctcatctgtg aggggcagcc agtgacgtca cggctggctg tcatctgtgg aacgtcttct    960

tgtcacatgg ggatcagcaa agacccgatt tttgtaccag gcgtctgggg gccttatttc   1020

tcagccatgg tacctgggtt ctggctgaat gaaggtggtc agagcgttac tggaaaattg   1080

atagaccaca tggtacaagg ccatgctgct tttccagaac tacaagtaaa ggccacagcc   1140

aggtaactgc tgtctctgtt ccctctaaaa ttttccttgt gtgactgtat tgagagaatt   1200

cacgttgggc agttgggtga ttttcagatc ctacagacaa tgaaaatgcc tgttagtgct   1260

tgaaagatag tcacctggat gatccagaag atagatgtat taattcttta aatgaggtaa   1320

gagaacttag agaacctaga gataccccaa gaatataccc agggactata gataagaaac   1380

tctgatgtag aagaaggacc atggattctg gagtcaaaac ttcttagttt cacatcccag   1440

ccatactcct taatagatac aggaccttga gctagttact taacctcttt atgcctgtct   1500

cttcatctgt aaaactgaag ataataactg atatggagtg atttctagaa tattttgaag   1560

caagctgagt gcaaaaaaaa tttacgatat actccctttc atgtaaaaag aaagacatag   1620

gaaaatacat gtgtatctgt tcatttttgc aaaagaaata taggaagtgg ccaggtgcgg   1680

tggctcactc ctgtaacccc agcaccttgg gaggccgagg cgggcagatc acgagttcag   1740

agatcgagac cagcctggcc aacatggtga aaccccatct ctactaaaaa tacaaaagtt   1800

agccgggcat ggtgatgtat gcctataatc ccagttactt gggaggttga ggcaggagaa   1860

ttgctcaaac ccgggaggtg gaggttgcag tgagcagaga tcgtgccact gcactccagc   1920

ctgggcaata aagtgagact ccgtctc                                       1947


<210>  6454
<211>  246
<212>  PRT
<213>  Homosapiens

<400>  6454

Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu 
1               5                   10                  15      


Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu 
            20                  25                  30          


Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile 
        35                  40                  45              


Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser 
    50                  55                  60                  


Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys 
65                  70                  75                  80  


Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys 
                85                  90                  95      


Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly 
            100                 105                 110         


Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro 
        115                 120                 125             


Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala 
    130                 135                 140                 


Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp 
145                 150                 155                 160 


Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg 
                165                 170                 175     


Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys 
            180                 185                 190         


Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met 
        195                 200                 205             


Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys 
    210                 215                 220                 


Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln 
225                 230                 235                 240 


Val Lys Ala Thr Ala Arg 
                245     


<210>  6455
<211>  2509
<212>  DNA
<213>  Homosapiens

<400>  6455
agaggcttct ccaacccggc ccggcccttc cttccccttt cccgcagtcg ttgcctcctc     60

ctcccctgcc tcctcctccc cttcctcctc ctggccgctt agtctcacac ccgccgggcc    120

gttgttcccg agacgttgtt gagtcccctg tgtcctcttc tggactacgc caagccacag    180

gtggaggaac tgcaatgtct ggtggagaac agaaaccaga gaggtactat gtgggtgtgg    240

acgttggaac aggcagtgtc cgtgcagctc tggtggacca gagtggggtc ctgttggctt    300

ttgcagacca gccaattaag aattgggagc cccagttcaa ccaccatgag cagtcctccg    360

aggacatctg ggctgcgtgc tgtgttgtca caaagaaagt tgtacaaggg attgatttaa    420

accaaattcg aggacttggg tttgatgcca cgtgttctct ggttgttttg gataagcagt    480

ttcacccatt accagtcaac caggaagggg attcccatcg aaacgtcatc atgtggctgg    540

accatcgagc agtcagtcaa gttaacagga tcaatgagac caagcacagt gtcctccagt    600

acgtcggggg ggtgatgtct gtggaaatgc aggccccgaa acttctgtgg ctgaaagaga    660

acttgagaga gatttgctgg gataaggcgg gacatttctt tgatctcccg gacttcttat    720

cgtggaaggc aacaggtgtc acagcacggt ctctctgctc cctggtgtgt aagtggacat    780

attcagcaga gaaaggctgg gacgacagtt tctggaaaat gattggtttg gaagactttg    840

ttgcagataa ttacagcaaa ataggaaacc aagtgctacc tcctggagct tctcttggaa    900

atgggctcac accagaggca gcaagagacc ttggccttct ccctgggatt gcggtcgcag    960

cttcactcat tgatgcccat gcaggaggac taggagtgat tggggcagat gtgagagggc   1020

acggcctcat ctgtgagggg cagccagtga cgtcacggct ggctgtcatc tgtggaacgt   1080

cttcttgtca catggggatc agcaaagacc cgatttttgt accaggcgtc tgggggcctt   1140

atttctcagc catggtacct gggttctggc tgaatgaagg tggtcagagc gttactggaa   1200

aattgataga ccacatggta caaggccatg ctgcttttcc agaactacaa gtaaaggcca   1260

cagccagatg ccagagtata tatgcatatt tgaacagtca cctggatctg attaagaagg   1320

ctcagcctgt gggtttcctt actgttgatt tacatgtttg gccagatttc catggcaacc   1380

ggtctccctt agcagatctg acactaaagg gcatggtcac cggattgaaa ctgtctcagg   1440

accttgatga tcttgccatt ctctacctgg ccacagttca agccattgct ttggggactc   1500

gcttcattat agaagccatg gaggcagcag ggcactcaat cagtactctt ttcctatgtg   1560

gaggcctcag caagaatccc ctttttgtgc aaatgcatgc ggacattact ggcatgcctg   1620

tggtcctgtc gcaagaggtg gagtccgttc ttgtgggtgc tgctgttctg ggtgcctgtg   1680

cctcagggga tttcgcttct gtacagtggg ggaaatagat agctcagttg tggacgatag   1740

cagcaatggg aagcagtatt tgagaagaaa tcagactctc ttcttccagt cttttgcaag   1800

acagctgtcc ccaaagggat gaatccatta cctttcacca gagttgagtt cgttttccat   1860

ttcatctttc tgcttaaaga gaaagccctt taaaagcgca gcgcatacat tgagtgcgtg   1920

tacttaattt ttaatatgtg tgtgcccaca gccaagagaa cagagaacct taaataataa   1980

tgaaactgaa ttgtacatgt cgtatgtttt atgtggcact gattcctaaa tatgctccta   2040

gcagccaggt attatttaat acatccccat taatcaagct gccaaatcta aatgaaaacc   2100

atgtttaaat atgtttaata agattatagc ttttggttga atatcaaact aacatagcta   2160

catttttcct tccagccagc tctcatttac tgtcttacat ttttactctg aaagcttttg   2220

tactatcaaa ccaatcttga ttataaaaca aattatacca caaactttta gtatcgtgag   2280

cttcagctga gtccctcagt gtaaatgtta ggagaaagaa cagttctgag attttttttc   2340

tggctaaaaa atgatatttt tcttcttctt ggggtgagcc tttgagttta aaaggaaatt   2400

aaaaattcaa ttagagatac taaattgttt gtagcttctg tattaaatga tgtctgcctt   2460

ttgcatagtt attgaaagtg tttcatatta aatgtacttt ttctttttg               2509


<210>  6456
<211>  507
<212>  PRT
<213>  Homosapiens

<400>  6456

Met Ser Gly Gly Glu Gln Lys Pro Glu Arg Tyr Tyr Val Gly Val Asp 
1               5                   10                  15      


Val Gly Thr Gly Ser Val Arg Ala Ala Leu Val Asp Gln Ser Gly Val 
            20                  25                  30          


Leu Leu Ala Phe Ala Asp Gln Pro Ile Lys Asn Trp Glu Pro Gln Phe 
        35                  40                  45              


Asn His His Glu Gln Ser Ser Glu Asp Ile Trp Ala Ala Cys Cys Val 
    50                  55                  60                  


Val Thr Lys Lys Val Val Gln Gly Ile Asp Leu Asn Gln Ile Arg Gly 
65                  70                  75                  80  


Leu Gly Phe Asp Ala Thr Cys Ser Leu Val Val Leu Asp Lys Gln Phe 
                85                  90                  95      


His Pro Leu Pro Val Asn Gln Glu Gly Asp Ser His Arg Asn Val Ile 
            100                 105                 110         


Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu 
        115                 120                 125             


Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu 
    130                 135                 140                 


Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile 
145                 150                 155                 160 


Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser 
                165                 170                 175     


Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys 
            180                 185                 190         


Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys 
        195                 200                 205             


Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly 
    210                 215                 220                 


Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro 
225                 230                 235                 240 


Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala 
                245                 250                 255     


Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp 
            260                 265                 270         


Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg 
        275                 280                 285             


Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys 
    290                 295                 300                 


Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met 
305                 310                 315                 320 


Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys 
                325                 330                 335     


Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln 
            340                 345                 350         


Val Lys Ala Thr Ala Arg Cys Gln Ser Ile Tyr Ala Tyr Leu Asn Ser 
        355                 360                 365             


His Leu Asp Leu Ile Lys Lys Ala Gln Pro Val Gly Phe Leu Thr Val 
    370                 375                 380                 


Asp Leu His Val Trp Pro Asp Phe His Gly Asn Arg Ser Pro Leu Ala 
385                 390                 395                 400 


Asp Leu Thr Leu Lys Gly Met Val Thr Gly Leu Lys Leu Ser Gln Asp 
                405                 410                 415     


Leu Asp Asp Leu Ala Ile Leu Tyr Leu Ala Thr Val Gln Ala Ile Ala 
            420                 425                 430         


Leu Gly Thr Arg Phe Ile Ile Glu Ala Met Glu Ala Ala Gly His Ser 
        435                 440                 445             


Ile Ser Thr Leu Phe Leu Cys Gly Gly Leu Ser Lys Asn Pro Leu Phe 
    450                 455                 460                 


Val Gln Met His Ala Asp Ile Thr Gly Met Pro Val Val Leu Ser Gln 
465                 470                 475                 480 


Glu Val Glu Ser Val Leu Val Gly Ala Ala Val Leu Gly Ala Cys Ala 
                485                 490                 495     


Ser Gly Asp Phe Ala Ser Val Gln Trp Gly Lys 
            500                 505         


<210>  6457
<211>  1979
<212>  DNA
<213>  Homosapiens

<400>  6457
agaggcttct ccaacccggc ccggcccttc cttccccttt cccgcagtcg ttgcctcctc     60

ctcccctgcc tcctcctccc cttcctcctc ctggccgctt agtctcacac ccgccgggcc    120

gttgttcccg agacgttgtt gagtcccctg tgtcctcttc tgggtggagg aactgcaatg    180

tctggtggag aacagaaacc agagaggtac tatgtgggtg tggacgttgg aacaggcagt    240

gtccgtgcag ctctggtgga ccagagtggg gtcctgttgg cttttgcaga ccagccaatt    300

aagaattggg agccccagtt caaccaccat gagcagtcct ccgaggacat ctgggctgcg    360

tgctgtgttg tcacaaagaa agttgtacaa gggattgatt taaaccaaat tcgaggactt    420

gggtttgatg ccacgtgttc tctggttgtt ttggataagc agtttcaccc attaccagtc    480

aaccaggaag gggattccca tcgaaacgtc atcatgtggc tggaccatcg agcagtcagt    540

caagttaaca ggatcaatga gaccaagcac agtgtcctcc agtacgtcgg gggggtgatg    600

tctgtggaaa tgcaggcccc gaaacttctg tggctgaaag agaacttgag agagatttgc    660

tgggataagg cgggacattt ctttgatctc ccggacttct tatcgtggaa ggcaacaggt    720

gtcacagcac ggtctctctg ctccctggtg tgtaagtgga catattcagc agagaaaggc    780

tgggacgaca gtttctggaa aatgattggt ttggaagact ttgttgcaga taattacagc    840

aaaataggaa accaagtgct acctcctgga gcttctcttg gaaatgggct cacaccagag    900

gcagcaagag accttggcct tctccctggg attgcggtcg cagcttcact cattgatgcc    960

catgcaggag gactaggagt gattggggca gatgtgagag ggcacggcct catctgtgag   1020

gggcagccag tgacgtcacg gctggctgtc atctgtggaa cgtcttcttg tcacatgggg   1080

atcagcaaag acccgatttt tgtaccaggc gtctgggggc cttatttctc agccatggta   1140

cctgggttct ggctgaatga aggtggtcag agcgttactg gaaaattgat agaccacatg   1200

gtacaaggcc atgctgcttt tccagaacta caagtaaagg ccacagccag atgccagagt   1260

atatatgcat atttgaacag tcacctggat ctgattaaga aggctcagcc tgtgggtttc   1320

cttactgttg atttacatgt ttggccagat ttccatggca accggtctcc cttagcagat   1380

ctgacactaa agggcatggt caccggattg aaactgtctc aggaccttga tgatcttgcc   1440

attctctacc tggccacagt tcaagccatt gctttgggga ctcgcttcat tatagaagcc   1500

atggaggcag cagggcactc aatcagtact cttttcctat gtggaggcct cagcaagaat   1560

cccctttttg tgcaaatgca tgcggacatt actggcatgc ctgtggtcct gtcgcaagag   1620

gtggagtccg ttcttgtggg tgctgctgtt ctgggtgcct gtgcctcagg ggatttcgct   1680

tctgtacagg aagcaatggc aaaaatgagc aaagttggga aagttgtgtt cccgagacta   1740

caggataaaa aatactatga taagaaatac caagtattcc tgaagctggt tgaacaccag   1800

aaggagtatt tggcgatcat gaatgatgac tgaacagggc ttgcaggtgc tgatgccaga   1860

agcttctgtg ccattgcatt aaagacttgt catttgatcc atgttcaaga cccttgaggt   1920

attgtttcat catttctgta ttgtctttca ataaagaaaa caaacatgtg caaccagaa    1979


<210>  6458
<211>  551
<212>  PRT
<213>  Homosapiens

<400>  6458

Met Ser Gly Gly Glu Gln Lys Pro Glu Arg Tyr Tyr Val Gly Val Asp 
1               5                   10                  15      


Val Gly Thr Gly Ser Val Arg Ala Ala Leu Val Asp Gln Ser Gly Val 
            20                  25                  30          


Leu Leu Ala Phe Ala Asp Gln Pro Ile Lys Asn Trp Glu Pro Gln Phe 
        35                  40                  45              


Asn His His Glu Gln Ser Ser Glu Asp Ile Trp Ala Ala Cys Cys Val 
    50                  55                  60                  


Val Thr Lys Lys Val Val Gln Gly Ile Asp Leu Asn Gln Ile Arg Gly 
65                  70                  75                  80  


Leu Gly Phe Asp Ala Thr Cys Ser Leu Val Val Leu Asp Lys Gln Phe 
                85                  90                  95      


His Pro Leu Pro Val Asn Gln Glu Gly Asp Ser His Arg Asn Val Ile 
            100                 105                 110         


Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu 
        115                 120                 125             


Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu 
    130                 135                 140                 


Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile 
145                 150                 155                 160 


Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser 
                165                 170                 175     


Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys 
            180                 185                 190         


Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys 
        195                 200                 205             


Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly 
    210                 215                 220                 


Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro 
225                 230                 235                 240 


Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala 
                245                 250                 255     


Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp 
            260                 265                 270         


Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg 
        275                 280                 285             


Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys 
    290                 295                 300                 


Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met 
305                 310                 315                 320 


Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys 
                325                 330                 335     


Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln 
            340                 345                 350         


Val Lys Ala Thr Ala Arg Cys Gln Ser Ile Tyr Ala Tyr Leu Asn Ser 
        355                 360                 365             


His Leu Asp Leu Ile Lys Lys Ala Gln Pro Val Gly Phe Leu Thr Val 
    370                 375                 380                 


Asp Leu His Val Trp Pro Asp Phe His Gly Asn Arg Ser Pro Leu Ala 
385                 390                 395                 400 


Asp Leu Thr Leu Lys Gly Met Val Thr Gly Leu Lys Leu Ser Gln Asp 
                405                 410                 415     


Leu Asp Asp Leu Ala Ile Leu Tyr Leu Ala Thr Val Gln Ala Ile Ala 
            420                 425                 430         


Leu Gly Thr Arg Phe Ile Ile Glu Ala Met Glu Ala Ala Gly His Ser 
        435                 440                 445             


Ile Ser Thr Leu Phe Leu Cys Gly Gly Leu Ser Lys Asn Pro Leu Phe 
    450                 455                 460                 


Val Gln Met His Ala Asp Ile Thr Gly Met Pro Val Val Leu Ser Gln 
465                 470                 475                 480 


Glu Val Glu Ser Val Leu Val Gly Ala Ala Val Leu Gly Ala Cys Ala 
                485                 490                 495     


Ser Gly Asp Phe Ala Ser Val Gln Glu Ala Met Ala Lys Met Ser Lys 
            500                 505                 510         


Val Gly Lys Val Val Phe Pro Arg Leu Gln Asp Lys Lys Tyr Tyr Asp 
        515                 520                 525             


Lys Lys Tyr Gln Val Phe Leu Lys Leu Val Glu His Gln Lys Glu Tyr 
    530                 535                 540                 


Leu Ala Ile Met Asn Asp Asp 
545                 550     


<210>  6459
<211>  1642
<212>  DNA
<213>  Homosapiens

<400>  6459
atgatcgcat ggagaatgga ttttgttgct ttatctgata ttgtcctcag ctcctcctga     60

atttgccgag atcttacagc agtcagtaag gtggaggaac tgcaatgtct ggtggagaac    120

agaaaccaga gaggtactat gtgggtgtgg acgttggaac aggcagtgtc cgtgcagctc    180

tggtggacca gagtggggtc ctgttggctt ttgcagacca gccaattaag aattgggagc    240

cccagttcaa ccaccatgag cagtcctccg aggacatctg ggctgcgtgc tgtgttgtca    300

caaagaactt gagagagatt tgctgggata aggcgggaca tttctttgat ctcccggact    360

tcttatcgtg gaaggcaaca ggtgtcacag cacggtctct ctgctccctg gtgtgtaagt    420

ggacatattc agcagagaaa ggctgggacg acagtttctg gaaaatgatt ggtttggaag    480

actttgttgc agataattac agcaaaatag gaaaccaagt gctacctcct ggagcttctc    540

ttggaaatgg gctcacacca gaggcagcaa gagaccttgg ccttctccct gggattgcgg    600

tcgcagcttc actcattgat gcccatgcag gaggactagg agtgattggg gcagatgtga    660

gagggcacgg cctcatctgt gaggggcagc cagtgacgtc acggctggct gtcatctgtg    720

gaacgtcttc ttgtcacatg gggatcagca aagacccgat ttttgtacca ggcgtctggg    780

ggccttattt ctcagccatg gtacctgggt tctggctgaa tgaaggtggt cagagcgtta    840

ctggaaaatt gatagaccac atggtacaag gccatgctgc ttttccagaa ctacaagtaa    900

aggccacagc cagatgccag agtatatatg catatttgaa cagtcacctg gatctgatta    960

agaaggctca gcctgtgggt ttccttactg ttgatttaca tgtttggcca gatttccatg   1020

gcaaccggtc tcccttagca gatctgacac taaagggcat ggtcaccgga ttgaaactgt   1080

ctcaggacct tgatgatctt gccattctct acctggccac agttcaagcc attgctttgg   1140

ggactcgctt cattatagaa gccatggagg cagcagggca ctcaatcagt actcttttcc   1200

tatgtggagg cctcagcaag aatccccttt ttgtgcaaat gcatgcggac attactggca   1260

tgcctgtggt cctgtcgcaa gaggtggagt ccgttcttgt gggtgctgct gttctgggtg   1320

cctgtgcctc aggggatttc gcttctgtac aggaagcaat ggcaaaaatg agcaaagttg   1380

ggaaagttgt gttcccgaga ctacaggata aaaaatacta tgataagaaa taccaagtat   1440

tcctgaagct ggttgaacac cagaaggagt atttggcgat catgaatgat gactgaacag   1500

ggcttgcagg tgctgatgcc agaagcttct gtgccattgc attaaagact tgtcatttga   1560

tccatgttca agacccttga ggtattgttt catcatttct gtattgtctt tcaataaaga   1620

aaacaaacat gtgcaaccag aa                                            1642


<210>  6460
<211>  463
<212>  PRT
<213>  Homosapiens

<400>  6460

Met Ser Gly Gly Glu Gln Lys Pro Glu Arg Tyr Tyr Val Gly Val Asp 
1               5                   10                  15      


Val Gly Thr Gly Ser Val Arg Ala Ala Leu Val Asp Gln Ser Gly Val 
            20                  25                  30          


Leu Leu Ala Phe Ala Asp Gln Pro Ile Lys Asn Trp Glu Pro Gln Phe 
        35                  40                  45              


Asn His His Glu Gln Ser Ser Glu Asp Ile Trp Ala Ala Cys Cys Val 
    50                  55                  60                  


Val Thr Lys Asn Leu Arg Glu Ile Cys Trp Asp Lys Ala Gly His Phe 
65                  70                  75                  80  


Phe Asp Leu Pro Asp Phe Leu Ser Trp Lys Ala Thr Gly Val Thr Ala 
                85                  90                  95      


Arg Ser Leu Cys Ser Leu Val Cys Lys Trp Thr Tyr Ser Ala Glu Lys 
            100                 105                 110         


Gly Trp Asp Asp Ser Phe Trp Lys Met Ile Gly Leu Glu Asp Phe Val 
        115                 120                 125             


Ala Asp Asn Tyr Ser Lys Ile Gly Asn Gln Val Leu Pro Pro Gly Ala 
    130                 135                 140                 


Ser Leu Gly Asn Gly Leu Thr Pro Glu Ala Ala Arg Asp Leu Gly Leu 
145                 150                 155                 160 


Leu Pro Gly Ile Ala Val Ala Ala Ser Leu Ile Asp Ala His Ala Gly 
                165                 170                 175     


Gly Leu Gly Val Ile Gly Ala Asp Val Arg Gly His Gly Leu Ile Cys 
            180                 185                 190         


Glu Gly Gln Pro Val Thr Ser Arg Leu Ala Val Ile Cys Gly Thr Ser 
        195                 200                 205             


Ser Cys His Met Gly Ile Ser Lys Asp Pro Ile Phe Val Pro Gly Val 
    210                 215                 220                 


Trp Gly Pro Tyr Phe Ser Ala Met Val Pro Gly Phe Trp Leu Asn Glu 
225                 230                 235                 240 


Gly Gly Gln Ser Val Thr Gly Lys Leu Ile Asp His Met Val Gln Gly 
                245                 250                 255     


His Ala Ala Phe Pro Glu Leu Gln Val Lys Ala Thr Ala Arg Cys Gln 
            260                 265                 270         


Ser Ile Tyr Ala Tyr Leu Asn Ser His Leu Asp Leu Ile Lys Lys Ala 
        275                 280                 285             


Gln Pro Val Gly Phe Leu Thr Val Asp Leu His Val Trp Pro Asp Phe 
    290                 295                 300                 


His Gly Asn Arg Ser Pro Leu Ala Asp Leu Thr Leu Lys Gly Met Val 
305                 310                 315                 320 


Thr Gly Leu Lys Leu Ser Gln Asp Leu Asp Asp Leu Ala Ile Leu Tyr 
                325                 330                 335     


Leu Ala Thr Val Gln Ala Ile Ala Leu Gly Thr Arg Phe Ile Ile Glu 
            340                 345                 350         


Ala Met Glu Ala Ala Gly His Ser Ile Ser Thr Leu Phe Leu Cys Gly 
        355                 360                 365             


Gly Leu Ser Lys Asn Pro Leu Phe Val Gln Met His Ala Asp Ile Thr 
    370                 375                 380                 


Gly Met Pro Val Val Leu Ser Gln Glu Val Glu Ser Val Leu Val Gly 
385                 390                 395                 400 


Ala Ala Val Leu Gly Ala Cys Ala Ser Gly Asp Phe Ala Ser Val Gln 
                405                 410                 415     


Glu Ala Met Ala Lys Met Ser Lys Val Gly Lys Val Val Phe Pro Arg 
            420                 425                 430         


Leu Gln Asp Lys Lys Tyr Tyr Asp Lys Lys Tyr Gln Val Phe Leu Lys 
        435                 440                 445             


Leu Val Glu His Gln Lys Glu Tyr Leu Ala Ile Met Asn Asp Asp 
    450                 455                 460             


<210>  6461
<211>  4569
<212>  DNA
<213>  Homosapiens

<400>  6461
agtctttgtt tcagcatcac tttccatgtt gcagacccaa ctacccaggt tttacatttt     60

aggaactgca tgacagggac agagggacag gtttcctctc cccgccagca ggctgctggc    120

tgcggcgccg cctctctcta ctccctcctc ccaccgcccc ccttccccgc ggttgggccc    180

actctgcggc ctctgcccgc ctcgccctcg cccgggcctc ctcccgcttt ctctctccgc    240

ttcccctgga gcctccgagg agtccgcagc cgctgggcgc ccgggaagat ggcggcggcg    300

gcgggagacg gcggcggcga ggggggcgcg ggcctgggca gcgcggcggg gctggggccg    360

gggccggggc tgcgcgggca gggcccctca gccgaagcgc acgagggcgc cccggacccg    420

atgcccgccg cgctgcaccc tgaggaggtc gccgcgcgac tgcagcggat gcagcgggag    480

ctgagcaacc gcaggaaaat cctggtgaaa aacctgcccc aggacagcaa ctgccaggaa    540

gttcatgatt tgttaaaaga ctatgactta aaatattgtt atgtggacag aaataaacga    600

acagcttttg ttaccttatt gaatggggaa caagcccaga acgcaattca gatgtttcat    660

caatattctt ttagaggaaa agacttaata gtccagcttc agccaacaga tgctttgttg    720

tgtattacca acgtgcccat ttcttttaca tcagaagagt ttgaagaact tgttcgtgct    780

tatggaaata ttgagagatg ttttctggtc tatagtgaag ttactggcca ttccaaaggc    840

tatggatttg tggaatacat gaaaaaggac tttgctgcaa aggctagact ggagctattg    900

ggtagacagt tgggagcatc agcactcttt gcacaatgga tggatgttaa tctattggct    960

tcagagctca ttcattctaa gtgcctttgt attgataaac tccccagtga ctacagggat   1020

tcagaagagc tgttgcaaat tttttccagt gtccataaac ctgtgttttg ccagcttgca   1080

caggatgaag gtagttacgt tggtggcttt gcagtggttg aatatagcac tgcggagcag   1140

gctgaagagg tccagcaggc agcagacggt atgaccatca agggcagcaa agtccaggtt   1200

tccttctgtg ctcctggagc gccagggcga agtacattag cagcattgat agcggctcaa   1260

cgtgtgatgc acagtaatca aaagggctta cttccagagc caaatccagt acaaattatg   1320

aaaagtttaa acaaccctgc catgttgcaa gttcttctac agccccagtt atgtggacga   1380

gctgttaaac cagccgttct tggaacacct cacagcttgc cacatctgat gaatccatcc   1440

atctctcctg catttttaca tttgaataaa gcacatcaga atctttctca tataccactg   1500

gcacaacaac aattaatgaa gtttgagaat attcatacta ataataaacc cggcttactt   1560

ggagagcccc cagctgtggt acttcagact gcactaggga tagggtcagt gcttccattg   1620

aaaaaggagt tgggacatca tcatggagaa gcacataaaa catctagcct gattccaact   1680

caaacaacga taacagctgg aatgggcatg ttaccattct ttccaaatca gcacattgct   1740

ggacaggctg ggccagggca cagtaatact caggagaaac agccagccac ggtgggaatg   1800

gcagaaggaa atttctcagg gtcgcagcct tatcttcaga gctttccaaa ccttgctgct   1860

ggaagcttgc tggtgggaca ccataagcag cagcaaagcc agccaaaagg cacagagata   1920

agttcagggg ctgcctctaa gaatcaaact tcactcttgg gagaaccacc aaaagaaatt   1980

cggctcagta aaaatccata cttgaatttg gcaagtgtgt tgcccagtgt gtgcttatca   2040

tcccctgcaa gtaaaaccac tcttcataag actggaattg caagcagcat tctggatgca   2100

atctctcagg gaagtgaatc acaacacgca ttggaaaagt gcattgctta ttctccacct   2160

tttggtgatt atgcacaggt gtcatcttta agaaatgaaa agcgaggctc atcatatctc   2220

atctctgccc cagaaggtgg ttcagtggaa tgtgttgacc agcattctca gggcacagga   2280

gcatattaca tggaaactta cttaaaaaag aagcgagtat actgagttaa gctctctcct   2340

aataaccccc taaggttctc tgcagtatct ctgctgttca tcgctgcctt aacttcattc   2400

aaactagcca tatcctttaa atacgggttt atagtttccc agaaggaact gtgttgtgca   2460

gcaggcagaa atgccaaata aaaaatagca ataagaagag acatcaattg aggacatttt   2520

ccactagagt cagatgcatc ttaatcagtg tgctaactta caatccattg gagaaactaa   2580

caatgttcca atattccttg atttaggact gggaataatt ctgacaccat atataaaaga   2640

agtttgaagc aataaatggg aaacagtgtt gtttcctgag ccttagaaga atgagtttct   2700

tataagccaa tgtgcatttc aatttacttt ccctagaagt aattgcattt atagattttt   2760

aggacttttc ctagaactac aagggtgcaa gtaccaaatg tgctgatggt aatattataa   2820

agatgctcta catgcacact caattacgcc cacaccagcc atgcaaaatt aaacccggta   2880

agagagtgac agtgatatcc aaggtatcca ctactaccga tgctttaaga tgttgtttac   2940

catttatacc ttctgtgaaa aatagaaggt attttaagaa aagtaacttt ggtgatctaa   3000

taaaagggtt tggcaaacta caccctgggt ccacatttgg tctaccaccc gcttttgtgc   3060

tgcctgcaag ctaagactaa tgtttacatt tttaaatggt tggaggaaaa aagaaaactt   3120

atgacatgaa atttatatga aattcagatt tcagtgtcca taaataaact tttattggga   3180

cgttgccatg ctcattcatt tacgtgttgt ctgtggcact cttacgctac aagggcagaa   3240

ctgattagct tcaacagaga ctgtatggcc tacaaagacc atatggccta aaatttcaag   3300

tatctggcca tttatatata gtttgctgat ccctgatcta atagcactaa ttctaatagc   3360

aactattcct ttcaattcac ctaaagacag acctttagcc tttagacaga cttgtaagtg   3420

gaaaggaaca tgggtttctg tgctcatttc atagcgtaga ctagtaatga tctaatgact   3480

agaatggggc ctattttgat cactaaatgc cctattattt ccacaatata gtatagtaaa   3540

gcagtcaata ctgcactttc tgatggagtc ttaaggagtc acagtattta taaccatttt   3600

gagctaataa gctatacctc actctctgct ttctctctca ctctttttga tagtgtgtta   3660

gggtgaaaaa tcagttattt aacccaattt acttgtgaaa gaagttttat ctttatggac   3720

tatgatgact tttgacatca ccatttcttg aagaccttgg tattaaatgc atgagaaacc   3780

ttttgccatc tagaaatttc taagtttgtt tatgttataa gactgtaatt aattgatagg   3840

gaatttggga tctcaatccg gggctttttg aaatcagatc attaaatatc tcgtcacttt   3900

ggggacttgt tatttttaac tatgatgtgg atatcctgtt ttaattatga agtctagaat   3960

tggtacatat gttgtatgct ttgtaaagaa tttcacttgg tctaatttat tgcatatact   4020

agcttctgtt ggaaaatgac tgacagctag aaagtttaag gtaatttcta agtatactac   4080

ctataagtaa ctgataagaa ttaggcatca ttcagtgata tagcagatga ctaatgggtt   4140

tttcaggccc tgcacttctc tttcccattt tcctgttgca ttcagcctct tcaatgctta   4200

gtcacacctc cactatagta caaacaaaca aacaaacaga agaaaggaaa gatggtgaat   4260

tttgcaacag agctgcaaaa agtcagtcag tcaaagcagg aagaggttga aggaactaaa   4320

acaaacaaac aaaggtgtct ggactacagc acagtggaca tgccatccat actggcctgt   4380

gccccgttat caatcactgg gcacaacagt gaagaagtgc aaatcaagtg gtgtttgttt   4440

gtttgttagt agtaaggacc gtaacccacc ccttcctccc cccaaaacta tactgttatt   4500

tttctatgta agcaaattgt ttgaaatgct ttgaaaatga aatcttaata ttaaaaggca   4560

tatgcatgt                                                           4569


<210>  6462
<211>  751
<212>  PRT
<213>  Homosapiens

<400>  6462

Met Thr Gly Thr Glu Gly Gln Val Ser Ser Pro Arg Gln Gln Ala Ala 
1               5                   10                  15      


Gly Cys Gly Ala Ala Ser Leu Tyr Ser Leu Leu Pro Pro Pro Pro Phe 
            20                  25                  30          


Pro Ala Val Gly Pro Thr Leu Arg Pro Leu Pro Ala Ser Pro Ser Pro 
        35                  40                  45              


Gly Pro Pro Pro Ala Phe Ser Leu Arg Phe Pro Trp Ser Leu Arg Gly 
    50                  55                  60                  


Val Arg Ser Arg Trp Ala Pro Gly Lys Met Ala Ala Ala Ala Gly Asp 
65                  70                  75                  80  


Gly Gly Gly Glu Gly Gly Ala Gly Leu Gly Ser Ala Ala Gly Leu Gly 
                85                  90                  95      


Pro Gly Pro Gly Leu Arg Gly Gln Gly Pro Ser Ala Glu Ala His Glu 
            100                 105                 110         


Gly Ala Pro Asp Pro Met Pro Ala Ala Leu His Pro Glu Glu Val Ala 
        115                 120                 125             


Ala Arg Leu Gln Arg Met Gln Arg Glu Leu Ser Asn Arg Arg Lys Ile 
    130                 135                 140                 


Leu Val Lys Asn Leu Pro Gln Asp Ser Asn Cys Gln Glu Val His Asp 
145                 150                 155                 160 


Leu Leu Lys Asp Tyr Asp Leu Lys Tyr Cys Tyr Val Asp Arg Asn Lys 
                165                 170                 175     


Arg Thr Ala Phe Val Thr Leu Leu Asn Gly Glu Gln Ala Gln Asn Ala 
            180                 185                 190         


Ile Gln Met Phe His Gln Tyr Ser Phe Arg Gly Lys Asp Leu Ile Val 
        195                 200                 205             


Gln Leu Gln Pro Thr Asp Ala Leu Leu Cys Ile Thr Asn Val Pro Ile 
    210                 215                 220                 


Ser Phe Thr Ser Glu Glu Phe Glu Glu Leu Val Arg Ala Tyr Gly Asn 
225                 230                 235                 240 


Ile Glu Arg Cys Phe Leu Val Tyr Ser Glu Val Thr Gly His Ser Lys 
                245                 250                 255     


Gly Tyr Gly Phe Val Glu Tyr Met Lys Lys Asp Phe Ala Ala Lys Ala 
            260                 265                 270         


Arg Leu Glu Leu Leu Gly Arg Gln Leu Gly Ala Ser Ala Leu Phe Ala 
        275                 280                 285             


Gln Trp Met Asp Val Asn Leu Leu Ala Ser Glu Leu Ile His Ser Lys 
    290                 295                 300                 


Cys Leu Cys Ile Asp Lys Leu Pro Ser Asp Tyr Arg Asp Ser Glu Glu 
305                 310                 315                 320 


Leu Leu Gln Ile Phe Ser Ser Val His Lys Pro Val Phe Cys Gln Leu 
                325                 330                 335     


Ala Gln Asp Glu Gly Ser Tyr Val Gly Gly Phe Ala Val Val Glu Tyr 
            340                 345                 350         


Ser Thr Ala Glu Gln Ala Glu Glu Val Gln Gln Ala Ala Asp Gly Met 
        355                 360                 365             


Thr Ile Lys Gly Ser Lys Val Gln Val Ser Phe Cys Ala Pro Gly Ala 
    370                 375                 380                 


Pro Gly Arg Ser Thr Leu Ala Ala Leu Ile Ala Ala Gln Arg Val Met 
385                 390                 395                 400 


His Ser Asn Gln Lys Gly Leu Leu Pro Glu Pro Asn Pro Val Gln Ile 
                405                 410                 415     


Met Lys Ser Leu Asn Asn Pro Ala Met Leu Gln Val Leu Leu Gln Pro 
            420                 425                 430         


Gln Leu Cys Gly Arg Ala Val Lys Pro Ala Val Leu Gly Thr Pro His 
        435                 440                 445             


Ser Leu Pro His Leu Met Asn Pro Ser Ile Ser Pro Ala Phe Leu His 
    450                 455                 460                 


Leu Asn Lys Ala His Gln Asn Leu Ser His Ile Pro Leu Ala Gln Gln 
465                 470                 475                 480 


Gln Leu Met Lys Phe Glu Asn Ile His Thr Asn Asn Lys Pro Gly Leu 
                485                 490                 495     


Leu Gly Glu Pro Pro Ala Val Val Leu Gln Thr Ala Leu Gly Ile Gly 
            500                 505                 510         


Ser Val Leu Pro Leu Lys Lys Glu Leu Gly His His His Gly Glu Ala 
        515                 520                 525             


His Lys Thr Ser Ser Leu Ile Pro Thr Gln Thr Thr Ile Thr Ala Gly 
    530                 535                 540                 


Met Gly Met Leu Pro Phe Phe Pro Asn Gln His Ile Ala Gly Gln Ala 
545                 550                 555                 560 


Gly Pro Gly His Ser Asn Thr Gln Glu Lys Gln Pro Ala Thr Val Gly 
                565                 570                 575     


Met Ala Glu Gly Asn Phe Ser Gly Ser Gln Pro Tyr Leu Gln Ser Phe 
            580                 585                 590         


Pro Asn Leu Ala Ala Gly Ser Leu Leu Val Gly His His Lys Gln Gln 
        595                 600                 605             


Gln Ser Gln Pro Lys Gly Thr Glu Ile Ser Ser Gly Ala Ala Ser Lys 
    610                 615                 620                 


Asn Gln Thr Ser Leu Leu Gly Glu Pro Pro Lys Glu Ile Arg Leu Ser 
625                 630                 635                 640 


Lys Asn Pro Tyr Leu Asn Leu Ala Ser Val Leu Pro Ser Val Cys Leu 
                645                 650                 655     


Ser Ser Pro Ala Ser Lys Thr Thr Leu His Lys Thr Gly Ile Ala Ser 
            660                 665                 670         


Ser Ile Leu Asp Ala Ile Ser Gln Gly Ser Glu Ser Gln His Ala Leu 
        675                 680                 685             


Glu Lys Cys Ile Ala Tyr Ser Pro Pro Phe Gly Asp Tyr Ala Gln Val 
    690                 695                 700                 


Ser Ser Leu Arg Asn Glu Lys Arg Gly Ser Ser Tyr Leu Ile Ser Ala 
705                 710                 715                 720 


Pro Glu Gly Gly Ser Val Glu Cys Val Asp Gln His Ser Gln Gly Thr 
                725                 730                 735     


Gly Ala Tyr Tyr Met Glu Thr Tyr Leu Lys Lys Lys Arg Val Tyr 
            740                 745                 750     


<210>  6463
<211>  5999
<212>  DNA
<213>  Homosapiens

<400>  6463
agtctttgtt tcagcatcac tttccatgtt gcagacccaa ctacccaggt tttacatttt     60

aggaactgca tgacagggac agagggacag gtttcctctc cccgccagca ggctgctggc    120

tgcggcgccg cctctctcta ctccctcctc ccaccgcccc ccttccccgc ggttgggccc    180

actctgcggc ctctgcccgc ctcgccctcg cccgggcctc ctcccgcttt ctctctccgc    240

ttcccctgga gcctccgagg agtccgcagc cgctgggcgc ccgggaagat ggcggcggcg    300

gcgggagacg gcggcggcga ggggggcgcg ggcctgggca gcgcggcggg gctggggccg    360

gggccggggc tgcgcgggca gggcccctca gccgaagcgc acgagggcgc cccggacccg    420

atgcccgccg cgctgcaccc tgaggaggtc gccgcgcgac tgcagcggat gcagcgggag    480

ctgagcaacc gcaggaaaat cctggtgaaa aacctgcccc aggacagcaa ctgccaggaa    540

gttcatgatt tgttaaaaga ctatgactta aaatattgtt atgtggacag aaataaacga    600

acagcttttg ttaccttatt gaatggggaa caagcccaga acgcaattca gatgtttcat    660

caatattctt ttagaggaaa agacttaata gtccagcttc agccaacaga tgctttgttg    720

tgtattacca acgtgcccat ttcttttaca tcagaagagt ttgaagaact tgttcgtgct    780

tatggaaata ttgagagatg ttttctggtc tatagtgaag ttactggcca ttccaaaggc    840

tatggatttg tggaatacat gaaaaaggac tttgctgcaa aggctagact ggagctattg    900

ggtagacagt tgggagcatc agcactcttt gcacaatgga tggatgttaa tctattggct    960

tcagagctca ttcattctaa gtgcctttgt attgataaac tccccagtga ctacagggat   1020

tcagaagagc tgttgcaaat tttttccagt gtccataaac ctgtgttttg ccagcttgca   1080

caggatgaag gtagttacgt tggtggcttt gcagtggttg aatatagcac tgcggagcag   1140

gctgaagagg tccagcaggc agcagacggt atgaccatca agggcagcaa agtccaggtt   1200

tccttctgtg ctcctggagc gccagggcga agtacattag cagcattgat agcggctcaa   1260

cgtgtgatgc acagtaatca aaagggctta cttccagagc caaatccagt acaaattatg   1320

aaaagtttaa acaaccctgc catgttgcaa gttcttctac agccccagtt atgtggacga   1380

gctgttaaac cagccgttct tggaacacct cacagcttgc cacatctgat gaatccatcc   1440

atctctcctg catttttaca tttgaataaa gcacatcaga atctttctca tataccactg   1500

gcacaacaac aattaatgaa gtttgagaat attcatacta ataataaacc cggcttactt   1560

ggagagcccc cagctgtggt acttcagact gcactaggga tagggtcagt gcttccattg   1620

aaaaaggagt tgggacatca tcatggagaa gcacataaaa catctagcct gattccaact   1680

caaacaacga taacagctgg aatgggcatg ttaccattct ttccaaatca gcacattgct   1740

ggacaggctg ggccagggca cagtaatact caggagaaac agccagccac ggtgggaatg   1800

gcagaaggaa atttctcagg gtcgcagcct tatcttcaga gctttccaaa ccttgctgct   1860

ggaagcttgc tggtgggaca ccataagcag cagcaaagcc agccaaaagg cacagagata   1920

agttcagggg ctgcctctaa gaatcaaact tcactcttgg gagaaccacc aaaagaaatt   1980

cggctcagta aaaatccata cttgaatttg gcaagtgtgt tgcccagtgt gtgcttatca   2040

tcccctgcaa gtaaaaccac tcttcataag actggaattg caagcagcat tctggatgca   2100

atctctcagg gaagtgaatc acaacacgca ttggaaaagt gcattgctta ttctccacct   2160

tttggtgatt atgcacaggt gtcatcttta agaaatgaaa agcgaggctc atcatatctc   2220

atctctgccc cagaaggtgg ttcagtggaa tgtgttgacc agcattctca gggcacagga   2280

gcatattaca tggaaactta cttaaaaaag aagcgagtat actgagttaa gctctctcct   2340

aataaccccc taaggttctc tgcagtatct ctgctgttca tcgctgcctt aacttcattc   2400

aaactagcca tatcctttaa atacgggttt atagtttccc agaaggaact gtgttgtgca   2460

gcaggcagaa atgccaaata aaaaatagca ataagaagag acatcaattg aggacatttt   2520

ccactagagt cagatgcatc ttaatcagtg tgctaactta caatccattg gagaaactaa   2580

caatgttcca atattccttg atttaggact gggaataatt ctgacaccat atataaaaga   2640

agtttgaagc aataaatggg aaacagtgtt gtttcctgag ccttagaaga atgagtttct   2700

tataagccaa tgtgcatttc aatttacttt ccctagaagt aattgcattt atagattttt   2760

aggacttttc ctagaactac aagggtgcaa gtaccaaatg tgctgatggt aatattataa   2820

agatgctcta catgcacact caattacgcc cacaccagcc atgcaaaatt aaacccggta   2880

agagagtgac agtgatatcc aaggtatcca ctactaccga tgctttaaga tgttgtttac   2940

catttatacc ttctgtgaaa aatagaaggt attttaagaa aagtaacttt ggtgatctaa   3000

taaaagggtt tggcaaacta caccctgggt ccacatttgg tctaccaccc gcttttgtgc   3060

tgcctgcaag ctaagactaa tgtttacatt tttaaatggt tggaggaaaa aagaaaactt   3120

atgacatgaa atttatatga aattcagatt tcagtgtcca taaataaact tttattggga   3180

cgttgccatg ctcattcatt tacgtgttgt ctgtggcact cttacgctac aagggcagaa   3240

ctgattagct tcaacagaga ctgtatggcc tacaaagacc atatggccta aaatttcaag   3300

tatctggcca tttatatata gtttgctgat ccctgatcta atagcactaa ttctaatagc   3360

aactattcct ttcaattcac ctaaagacag acctttagcc tttagacaga cttgtaagtg   3420

gaaaggaaca tgggtttctg tgctcatttc atagcgtaga ctagtaatga tctaatgact   3480

agaatggggc ctattttgat cactaaatgc cctattattt ccacaatata gtatagtaaa   3540

gcagtcaata ctgcactttc tgatggagtc ttaaggagtc acagtattta taaccatttt   3600

gagctaataa gctatacctc actctctgct ttctctctca ctctttttga tagtgtgtta   3660

gggtgaaaaa tcagttattt aacccaattt acttgtgaaa gaagttttat ctttatggac   3720

tatgatgact tttgacatca ccatttcttg aagaccttgg tattaaatgc atgagaaacc   3780

ttttgccatc tagaaatttc taagtttgtt tatgttataa gactgtaatt aattgatagg   3840

gaatttggga tctcaatccg gggctttttg aaatcagatc attaaatatc tcgtcacttt   3900

ggggacttgt tatttttaac tatgatgtgg atatcctgtt ttaattatga agtctagaat   3960

tggtacatat gttgtatgct ttgtaaagaa tttcacttgg tctaatttat tgcatatact   4020

agcttctgtt ggaaaatgac tgacagctag aaagtttaag gtaatttcta agtatactac   4080

ctataagtaa ctgataagaa ttaggcatca ttcagtgata tagcagatga ctaatgggtt   4140

tttcaggccc tgcacttctc tttcccattt tcctgttgca ttcagcctct tcaatgctta   4200

gtcacacctc cactatagta caaacaaaca aacaaacaga agaaaggaaa gatggtgaat   4260

tttgcaacag agctgcaaaa agtcagtcag tcaaagcagg aagaggttga aggaactaaa   4320

acaaacaaac aaaggtgtct ggactacagc acagtggaca tgccatccat actggcctgt   4380

gccccgttat caatcactgg gcacaacagt gaagaagtgc aaatcaagtg gtgtttgttt   4440

gtttgttagt agtaaggacc gtaacccacc ccttcctccc cccaaaacta tactgttatt   4500

tttctatgta agcaaattgt ttgaaatgct ttgaaaatga aatcttaata ttaaaaggca   4560

tatgcatgta aagtctttag tatatttatt tgtataaaga gtaaacaaag tgcatataga   4620

gtggccacag gtttgacaca gagaccttgg tgatgtaggc tatgaacaaa tttaaatggc   4680

aacttcattg ctgccactga accaatcctg aatttgggct caacaggtga aaagtaacaa   4740

tatcaaacga atactaaaca gcataacaaa aagattttca gactcttggt cataaagacc   4800

gtaatcgttc acattgaatc aatgactaaa catttttgat tacccagcta cctccaagca   4860

aactgaaaac tgtctagtgg atcctgaagt ccatagtgcc tctagccggg tctttcaagt   4920

gttgcaccac agggtgatga ttgatggtaa aaacagggat caacccttgt agatcggtgg   4980

taagtatgga aaccctctaa gaacagtgca gcgtatgtgg tattcagact ggttgcatac   5040

agcattcaaa accagtgctg gaatagcttg ccccaaagtg gtagagttat aaaaggatat   5100

acattgacgt ttcttaaaag catgtgtaat agcatccagg ttctgggaat gagttctgat   5160

taaaggtata ctgcttagga aagcactggc acaggcttag ttcttgagaa ttaacatgca   5220

gcaaattatc tattccacag ctatcccccc atgtagaacc agctttctca aaaatgggtg   5280

ctagtgatca cccaaaggaa caggagctaa gccactggag aaacaaagtt taagtcctac   5340

tggtgagaga atacagtcat ttttgtacag aaacaatata tactacctgg tatctaatat   5400

tttaagaatg catggtctag tactgtatag atactgaaat ttgagggcta agtccatcaa   5460

tctttcttta tctatgatta atgtgccagc aaaacatttc agatcagctg gcagcaggga   5520

aaagcaatca tcttcagata ttattttggt caactcctcg ttttcaaaaa tccccttttg   5580

gtaatgcagt tgtgatggtg aactagccag atgaaatggt ggtatattct ttccacaagg   5640

aggagtgctt aagtgctttc aaatattttg gttgtcatta tgtgtcacta agttactggt   5700

accaaattta aagaggaagt ccttacacat attaagcact acagtgtgcc ttatacatgt   5760

atatgtactg aagtatgagt tcagtgactt tttggacaga acacaaactt ctttcattag   5820

aaatttttaa aaaatgactt gggcatttgt tgcaggagaa ggacttgata atctgtggaa   5880

tttaaatgtt attcatgctt cttattttaa aagtgcttca aatccttcaa taaggttctg   5940

aaagcttgtc cgattggatg gttggaattc ccagcatttc ctcataagtt gataaacct    5999


<210>  6464
<211>  751
<212>  PRT
<213>  Homosapiens

<400>  6464

Met Thr Gly Thr Glu Gly Gln Val Ser Ser Pro Arg Gln Gln Ala Ala 
1               5                   10                  15      


Gly Cys Gly Ala Ala Ser Leu Tyr Ser Leu Leu Pro Pro Pro Pro Phe 
            20                  25                  30          


Pro Ala Val Gly Pro Thr Leu Arg Pro Leu Pro Ala Ser Pro Ser Pro 
        35                  40                  45              


Gly Pro Pro Pro Ala Phe Ser Leu Arg Phe Pro Trp Ser Leu Arg Gly 
    50                  55                  60                  


Val Arg Ser Arg Trp Ala Pro Gly Lys Met Ala Ala Ala Ala Gly Asp 
65                  70                  75                  80  


Gly Gly Gly Glu Gly Gly Ala Gly Leu Gly Ser Ala Ala Gly Leu Gly 
                85                  90                  95      


Pro Gly Pro Gly Leu Arg Gly Gln Gly Pro Ser Ala Glu Ala His Glu 
            100                 105                 110         


Gly Ala Pro Asp Pro Met Pro Ala Ala Leu His Pro Glu Glu Val Ala 
        115                 120                 125             


Ala Arg Leu Gln Arg Met Gln Arg Glu Leu Ser Asn Arg Arg Lys Ile 
    130                 135                 140                 


Leu Val Lys Asn Leu Pro Gln Asp Ser Asn Cys Gln Glu Val His Asp 
145                 150                 155                 160 


Leu Leu Lys Asp Tyr Asp Leu Lys Tyr Cys Tyr Val Asp Arg Asn Lys 
                165                 170                 175     


Arg Thr Ala Phe Val Thr Leu Leu Asn Gly Glu Gln Ala Gln Asn Ala 
            180                 185                 190         


Ile Gln Met Phe His Gln Tyr Ser Phe Arg Gly Lys Asp Leu Ile Val 
        195                 200                 205             


Gln Leu Gln Pro Thr Asp Ala Leu Leu Cys Ile Thr Asn Val Pro Ile 
    210                 215                 220                 


Ser Phe Thr Ser Glu Glu Phe Glu Glu Leu Val Arg Ala Tyr Gly Asn 
225                 230                 235                 240 


Ile Glu Arg Cys Phe Leu Val Tyr Ser Glu Val Thr Gly His Ser Lys 
                245                 250                 255     


Gly Tyr Gly Phe Val Glu Tyr Met Lys Lys Asp Phe Ala Ala Lys Ala 
            260                 265                 270         


Arg Leu Glu Leu Leu Gly Arg Gln Leu Gly Ala Ser Ala Leu Phe Ala 
        275                 280                 285             


Gln Trp Met Asp Val Asn Leu Leu Ala Ser Glu Leu Ile His Ser Lys 
    290                 295                 300                 


Cys Leu Cys Ile Asp Lys Leu Pro Ser Asp Tyr Arg Asp Ser Glu Glu 
305                 310                 315                 320 


Leu Leu Gln Ile Phe Ser Ser Val His Lys Pro Val Phe Cys Gln Leu 
                325                 330                 335     


Ala Gln Asp Glu Gly Ser Tyr Val Gly Gly Phe Ala Val Val Glu Tyr 
            340                 345                 350         


Ser Thr Ala Glu Gln Ala Glu Glu Val Gln Gln Ala Ala Asp Gly Met 
        355                 360                 365             


Thr Ile Lys Gly Ser Lys Val Gln Val Ser Phe Cys Ala Pro Gly Ala 
    370                 375                 380                 


Pro Gly Arg Ser Thr Leu Ala Ala Leu Ile Ala Ala Gln Arg Val Met 
385                 390                 395                 400 


His Ser Asn Gln Lys Gly Leu Leu Pro Glu Pro Asn Pro Val Gln Ile 
                405                 410                 415     


Met Lys Ser Leu Asn Asn Pro Ala Met Leu Gln Val Leu Leu Gln Pro 
            420                 425                 430         


Gln Leu Cys Gly Arg Ala Val Lys Pro Ala Val Leu Gly Thr Pro His 
        435                 440                 445             


Ser Leu Pro His Leu Met Asn Pro Ser Ile Ser Pro Ala Phe Leu His 
    450                 455                 460                 


Leu Asn Lys Ala His Gln Asn Leu Ser His Ile Pro Leu Ala Gln Gln 
465                 470                 475                 480 


Gln Leu Met Lys Phe Glu Asn Ile His Thr Asn Asn Lys Pro Gly Leu 
                485                 490                 495     


Leu Gly Glu Pro Pro Ala Val Val Leu Gln Thr Ala Leu Gly Ile Gly 
            500                 505                 510         


Ser Val Leu Pro Leu Lys Lys Glu Leu Gly His His His Gly Glu Ala 
        515                 520                 525             


His Lys Thr Ser Ser Leu Ile Pro Thr Gln Thr Thr Ile Thr Ala Gly 
    530                 535                 540                 


Met Gly Met Leu Pro Phe Phe Pro Asn Gln His Ile Ala Gly Gln Ala 
545                 550                 555                 560 


Gly Pro Gly His Ser Asn Thr Gln Glu Lys Gln Pro Ala Thr Val Gly 
                565                 570                 575     


Met Ala Glu Gly Asn Phe Ser Gly Ser Gln Pro Tyr Leu Gln Ser Phe 
            580                 585                 590         


Pro Asn Leu Ala Ala Gly Ser Leu Leu Val Gly His His Lys Gln Gln 
        595                 600                 605             


Gln Ser Gln Pro Lys Gly Thr Glu Ile Ser Ser Gly Ala Ala Ser Lys 
    610                 615                 620                 


Asn Gln Thr Ser Leu Leu Gly Glu Pro Pro Lys Glu Ile Arg Leu Ser 
625                 630                 635                 640 


Lys Asn Pro Tyr Leu Asn Leu Ala Ser Val Leu Pro Ser Val Cys Leu 
                645                 650                 655     


Ser Ser Pro Ala Ser Lys Thr Thr Leu His Lys Thr Gly Ile Ala Ser 
            660                 665                 670         


Ser Ile Leu Asp Ala Ile Ser Gln Gly Ser Glu Ser Gln His Ala Leu 
        675                 680                 685             


Glu Lys Cys Ile Ala Tyr Ser Pro Pro Phe Gly Asp Tyr Ala Gln Val 
    690                 695                 700                 


Ser Ser Leu Arg Asn Glu Lys Arg Gly Ser Ser Tyr Leu Ile Ser Ala 
705                 710                 715                 720 


Pro Glu Gly Gly Ser Val Glu Cys Val Asp Gln His Ser Gln Gly Thr 
                725                 730                 735     


Gly Ala Tyr Tyr Met Glu Thr Tyr Leu Lys Lys Lys Arg Val Tyr 
            740                 745                 750     


<210>  6465
<211>  2988
<212>  DNA
<213>  Homosapiens

<400>  6465
cagcttttgt taccttattg aatggggaac aagcccagaa cgcaattcag atgtttcatc     60

aatattcttt tagaggaaaa gacttaatag tccagcttca gccaacagat gctttgttgt    120

gtattaccaa cgtgcccatt tcttttacat cagaagagtt tgaagaactt gttcgtgctt    180

atggaaatat tgagagatgt tttctggtct atagtgaagt tactggccat tccaaaggct    240

atggatttgt ggaatacatg aaaaaggact ttgctgcaaa ggctagactg gagctattgg    300

gtagacagtt gggagcatca gcactctttg cacaatggat ggatgttaat ctattggctt    360

cagagctcat tcattctaag tgcctttgta ttgataaact ccccagtgac tacagggatt    420

cagaagagct gttgcaaatt ttttccagtg tccataaacc tgtgttttgc cagcttgcac    480

aggatgaagg tagttacgtt ggtggctttg cagtggttga atatagcact gcggagcagg    540

ctgaagaggt ccagcaggca gcagacggta tgaccatcaa gggcagcaaa gtccaggttt    600

ccttctgtgc tcctggagcg ccagggcgaa gtacattagc agcattgata gcggctcaac    660

gtgtgatgca cagtaatcaa aagggcttac ttccagagcc aaatccagta caaattatga    720

aaagtttaaa caaccctgcc atgttgcaag ttcttctaca gccccagtta tgtggacgag    780

ctgttaaacc agccgttctt ggaacacctc acagcttgcc acatctgatg aatccatcca    840

tctctcctgc atttttacat ttgaataaag cacatcagaa tctttctcat ataccactgg    900

cacaacaaca attaatgaag tttgagaata ttcatactaa taataaaccc ggcttacttg    960

gagagccccc agctgtggta cttcagactg cactagggat agggtcagtg cttccattga   1020

aaaaggagtt gggacatcat catggagaag cacataaaag ctgcctctaa gaatcaaact   1080

tcactcttgg gagaaccacc aaaagaaatt cggctcagta aaaatccata cttgaatttg   1140

gcaagtgtgt tgcccagtgt gtgcttatca tcccctgcaa gtaaaaccac tcttcataag   1200

actggaattg caagcagcat tctggatgca atctctcagg gaagtgaatc acaacacgca   1260

ttggaaaagt gcattgctta ttctccacct tttggtgatt atgcacaggt aaataattcc   1320

caggttctga tgatactcag aaaaattggt tcaactatat attgagttca ctgaatatga   1380

aattgtgatt tctatattat taacgtaggc aaatcaaatt gcactgatct atgtatttct   1440

tactcatcat ttgaaatttg ggaatgtgtt caagacatta tttagtatca ttttgcacta   1500

gatatttacc tctcactgtt tacctagtgg ttggcaaact acagcccata gaacaaatct   1560

agcccaccac ctggttttgt aaataaattt gtattgtaat acagccatgt ccattcatta   1620

acatattgtc tatggtgctg tcatgctata ataaaagagt tgagtgatga cagtagagac   1680

tatgtggcct gcaagattaa atatttacta tctggttctt tatagaaaaa tgctgctaac   1740

ctctggtttg cactagtgta gacctaagaa acccaaggga atgcctctgt tcttctccac   1800

tgattgtaga tggagaaaga tgatcatatt tacagacact actgtgctaa cttctaaacc   1860

agccaatcaa taacataaaa atattatgtt cataagatgt cctgtgtcat tacttaaata   1920

tttcagtttt gctttggccc ttcttcagct tactcttagt ggtgtaagct gaatatatat   1980

catgttagcc ctgtgtgatt atggaatcat aagagtccac aagagtctta taattatcag   2040

ttctgactct tactttccta gaacagccag cttcttctca gatctatcct gttcgttgga   2100

gtcttgtctc cactttgatt tccctggagc agctttgtgt ttgcctgacc catccctaat   2160

aaacttagaa aagaaaacca cttagaacaa ttgacgcctg attataagag tactagaaac   2220

agcccaagtt ctgtaaaaat ggtgcagctg gatattagtg aaatatttgc catctcttat   2280

atacctggga caagacggaa aaatatgggt tgggtagatg atgtaattag gtgacagtat   2340

atctatattt agagaacagt gatcacaaat tgctgcagtc tgaaggcatt ctcttatatt   2400

gattcataag agtcatcttc agtcctttat tagataacat ttgaagtaat gacttagata   2460

aagacattaa ttgtaaaatt tacaagatat agtcctgtac aattccaatt tgtttctttt   2520

caagaaacaa actttttata aacaggagaa gcacaataaa ttttttaaaa attcattaaa   2580

tacatattta agctttaaaa attttttgaa cttttatttc tttttaaatt tgcctttttc   2640

ttagcagttt tgcttattag attactgtga tttattgtat acttatatcc atggaaagac   2700

tttctcattc acacatggag aaattctgtg ataatgatgc cttttgcatt actgtatgtc   2760

ttctgcctcc acacttgctt gcccagagat atggtgggga aatgaatcct ccctgcactg   2820

ttcagtgtct cctttgacag tccctgcttc tagcgcacgc ttgttcataa aatgggattt   2880

gttctctctc tcgtgttctt tcttccttat aaacttaatt aaatgttact aatggaacat   2940

taaagtacat ggaattaaac taatggaata ctaaaataac cattatag                2988


<210>  6466
<211>  339
<212>  PRT
<213>  Homosapiens

<400>  6466

Met Phe His Gln Tyr Ser Phe Arg Gly Lys Asp Leu Ile Val Gln Leu 
1               5                   10                  15      


Gln Pro Thr Asp Ala Leu Leu Cys Ile Thr Asn Val Pro Ile Ser Phe 
            20                  25                  30          


Thr Ser Glu Glu Phe Glu Glu Leu Val Arg Ala Tyr Gly Asn Ile Glu 
        35                  40                  45              


Arg Cys Phe Leu Val Tyr Ser Glu Val Thr Gly His Ser Lys Gly Tyr 
    50                  55                  60                  


Gly Phe Val Glu Tyr Met Lys Lys Asp Phe Ala Ala Lys Ala Arg Leu 
65                  70                  75                  80  


Glu Leu Leu Gly Arg Gln Leu Gly Ala Ser Ala Leu Phe Ala Gln Trp 
                85                  90                  95      


Met Asp Val Asn Leu Leu Ala Ser Glu Leu Ile His Ser Lys Cys Leu 
            100                 105                 110         


Cys Ile Asp Lys Leu Pro Ser Asp Tyr Arg Asp Ser Glu Glu Leu Leu 
        115                 120                 125             


Gln Ile Phe Ser Ser Val His Lys Pro Val Phe Cys Gln Leu Ala Gln 
    130                 135                 140                 


Asp Glu Gly Ser Tyr Val Gly Gly Phe Ala Val Val Glu Tyr Ser Thr 
145                 150                 155                 160 


Ala Glu Gln Ala Glu Glu Val Gln Gln Ala Ala Asp Gly Met Thr Ile 
                165                 170                 175     


Lys Gly Ser Lys Val Gln Val Ser Phe Cys Ala Pro Gly Ala Pro Gly 
            180                 185                 190         


Arg Ser Thr Leu Ala Ala Leu Ile Ala Ala Gln Arg Val Met His Ser 
        195                 200                 205             


Asn Gln Lys Gly Leu Leu Pro Glu Pro Asn Pro Val Gln Ile Met Lys 
    210                 215                 220                 


Ser Leu Asn Asn Pro Ala Met Leu Gln Val Leu Leu Gln Pro Gln Leu 
225                 230                 235                 240 


Cys Gly Arg Ala Val Lys Pro Ala Val Leu Gly Thr Pro His Ser Leu 
                245                 250                 255     


Pro His Leu Met Asn Pro Ser Ile Ser Pro Ala Phe Leu His Leu Asn 
            260                 265                 270         


Lys Ala His Gln Asn Leu Ser His Ile Pro Leu Ala Gln Gln Gln Leu 
        275                 280                 285             


Met Lys Phe Glu Asn Ile His Thr Asn Asn Lys Pro Gly Leu Leu Gly 
    290                 295                 300                 


Glu Pro Pro Ala Val Val Leu Gln Thr Ala Leu Gly Ile Gly Ser Val 
305                 310                 315                 320 


Leu Pro Leu Lys Lys Glu Leu Gly His His His Gly Glu Ala His Lys 
                325                 330                 335     


Ser Cys Leu 
            


<210>  6467
<211>  5108
<212>  DNA
<213>  Homosapiens

<400>  6467
gggaggcggt gcgtcgctga gcgcaggccg cggcggccgc ggagtatcct ggagctgcag     60

acagtgcggg cctgcgccca gtcccggctg tcctcgccgc gacccctcct cagccctggg    120

cgcgcgcacg ctggggcccc gcggggctgg ccgcctagcg agcctgccgg tcgaccccag    180

ccagcgcagc gacggggcgc tgcctggccc aggcgcacac ggaagtgcgc ttctctgaag    240

tagctttgga aagtagagaa gaaaatccag tttgcttctt ggagaacact ggacagctga    300

ataaatgcag tatctaaata taaaagagga ctgcaatgcc atggctttct gtgctaaaat    360

gaggagctcc aagaagactg aggtgaacct ggaggcccct gagccagggg tggaagtgat    420

cttctatctg tcggacaggg agcccctccg gctgggcagt ggagagtaca cagcagagga    480

actgtgcatc agggctgcac aggcatgccg tatctctcct ctttgtcaca acctctttgc    540

cctgtatgac gagaacacca agctctggta tgctccaaat cgcaccatca ccgttgatga    600

caagatgtcc ctccggctcc actaccggat gaggttctat ttcaccaatt ggcatggaac    660

caacgacaat gagcagtcag tgtggcgtca ttctccaaag aagcagaaaa atggctacga    720

gaaaaaaaag attccagatg caacccctct ccttgatgcc agctcactgg agtatctgtt    780

tgctcaggga cagtatgatt tggtgaaatg cctggctcct attcgagacc ccaagaccga    840

gcaggatgga catgatattg agaacgagtg tctagggatg gctgtcctgg ccatctcaca    900

ctatgccatg atgaagaaga tgcagttgcc agaactgccc aaggacatca gctacaagcg    960

atatattcca gaaacattga ataagtccat cagacagagg aaccttctca ccaggatgcg   1020

gataaataat gttttcaagg atttcctaaa ggaatttaac aacaagacca tttgtgacag   1080

cagcgtgtcc acgcatgacc tgaaggtgaa atacttggct accttggaaa ctttgacaaa   1140

acattacggt gctgaaatat ttgagacttc catgttactg atttcatcag aaaatgagat   1200

gaattggttt cattcgaatg acggtggaaa cgttctctac tacgaagtga tggtgactgg   1260

gaatcttgga atccagtgga ggcataaacc aaatgttgtt tctgttgaaa aggaaaaaaa   1320

taaactgaag cggaaaaaac tggaaaataa acacaagaag gatgaggaga aaaacaagat   1380

ccgggaagag tggaacaatt tttcttactt ccctgaaatc actcacattg taataaagga   1440

gtctgtggtc agcattaaca agcaggacaa caagaaaatg gaactgaagc tctcttccca   1500

cgaggaggcc ttgtcctttg tgtccctggt agatggctac ttccggctca cagcagatgc   1560

ccatcattac ctctgcaccg acgtggcccc cccgttgatc gtccacaaca tacagaatgg   1620

ctgtcatggt ccaatctgta cagaatacgc catcaataaa ttgcggcaag aaggaagcga   1680

ggaggggatg tacgtgctga ggtggagctg caccgacttt gacaacatcc tcatgaccgt   1740

cacctgcttt gagaagtctg agcaggtgca gggtgcccag aagcagttca agaactttca   1800

gatcgaggtg cagaagggcc gctacagtct gcacggttcg gaccgcagct tccccagctt   1860

gggagacctc atgagccacc tcaagaagca gatcctgcgc acggataaca tcagcttcat   1920

gctaaaacgc tgctgccagc ccaagccccg agaaatctcc aacctgctgg tggctactaa   1980

gaaagcccag gagtggcagc ccgtctaccc catgagccag ctgagtttcg atcggatcct   2040

caagaaggat ctggtgcagg gcgagcacct tgggagaggc acgagaacac acatctattc   2100

tgggaccctg atggattaca aggatgacga aggaacttct gaagagaaga agataaaagt   2160

gatcctcaaa gtcttagacc ccagccacag ggatatttcc ctggccttct tcgaggcagc   2220

cagcatgatg agacaggtct cccacaaaca catcgtgtac ctctatggcg tctgtgtccg   2280

cgacgtggag aatatcatgg tggaagagtt tgtggaaggg ggtcctctgg atctcttcat   2340

gcaccggaaa agcgatgtcc ttaccacacc atggaaattc aaagttgcca aacagctggc   2400

cagtgccctg agctacttgg aggataaaga cctggtccat ggaaatgtgt gtactaaaaa   2460

cctcctcctg gcccgtgagg gcatcgacag tgagtgtggc ccattcatca agctcagtga   2520

ccccggcatc cccattacgg tgctgtctag gcaagaatgc attgaacgaa tcccatggat   2580

tgctcctgag tgtgttgagg actccaagaa cctgagtgtg gctgctgaca agtggagctt   2640

tggaaccacg ctctgggaaa tctgctacaa tggcgagatc cccttgaaag acaagacgct   2700

gattgagaaa gagagattct atgaaagccg gtgcaggcca gtgacaccat catgtaagga   2760

gctggctgac ctcatgaccc gctgcatgaa ctatgacccc aatcagaggc ctttcttccg   2820

agccatcatg agagacatta ataagcttga agagcagaat ccagatattg tttcagaaaa   2880

aaaaccagca actgaagtgg accccacaca ttttgaaaag cgcttcctaa agaggatccg   2940

tgacttggga gagggccact ttgggaaggt tgagctctgc aggtatgacc ccgaagggga   3000

caatacaggg gagcaggtgg ctgttaaatc tctgaagcct gagagtggag gtaaccacat   3060

agctgatctg aaaaaggaaa tcgagatctt aaggaacctc tatcatgaga acattgtgaa   3120

gtacaaagga atctgcacag aagacggagg aaatggtatt aagctcatca tggaatttct   3180

gccttcggga agccttaagg aatatcttcc aaagaataag aacaaaataa acctcaaaca   3240

gcagctaaaa tatgccgttc agatttgtaa ggggatggac tatttgggtt ctcggcaata   3300

cgttcaccgg gacttggcag caagaaatgt ccttgttgag agtgaacacc aagtgaaaat   3360

tggagacttc ggtttaacca aagcaattga aaccgataag gagtattaca ccgtcaagga   3420

tgaccgggac agccctgtgt tttggtatgc tccagaatgt ttaatgcaat ctaaatttta   3480

tattgcctct gacgtctggt cttttggagt cactctgcat gagctgctga cttactgtga   3540

ttcagattct agtcccatgg ctttgttcct gaaaatgata ggcccaaccc atggccagat   3600

gacagtcaca agacttgtga atacgttaaa agaaggaaaa cgcctgccgt gcccacctaa   3660

ctgtccagat gaggtttatc aacttatgag gaaatgctgg gaattccaac catccaatcg   3720

gacaagcttt cagaacctta ttgaaggatt tgaagcactt ttaaaataag aagcatgaat   3780

aacatttaaa ttccacagat tatcaagtcc ttctcctgca acaaatgccc aagtcatttt   3840

ttaaaaattt ctaatgaaag aagtttgtgt tctgtccaaa aagtcactga actcatactt   3900

cagtacatat acatgtataa ggcacactgt agtgcttaat atgtgtaagg acttcctctt   3960

taaatttggt accagtaact tagtgacaca taatgacaac caaaatattt gaaagcactt   4020

aagcactcct ccttgtggaa agaatatacc accatttcat ctggctagtt caccatcaca   4080

actgcattac caaaagggga tttttgaaaa cgaggagttg accaaaataa tatctgaaga   4140

tgattgcttt tccctgctgc cagctgatct gaaatgtttt gctggcacat taatcataga   4200

taaagaaaga ttgatggact tagccctcaa atttcagtat ctatacagta ctagaccatg   4260

cattcttaaa atattagata ccaggtagta tatattgttt ctgtacaaaa atgactgtat   4320

tctctcacca gtaggactta aactttgttt ctccagtggc ttagctcctg ttcctttggg   4380

tgatcactag cacccatttt tgagaaagct ggttctacat ggggggatag ctgtggaata   4440

gataatttgc tgcatgttaa ttctcaagaa ctaagcctgt gccagtgctt tcctaagcag   4500

tataccttta atcagaactc attcccagaa cctggatgct attacacatg cttttaagaa   4560

acgtcaatgt atatcctttt ataactctac cactttgggg caagctattc cagcactggt   4620

tttgaatgct gtatgcaacc agtctgaata ccacatacgc tgcactgttc ttagagggtt   4680

tccatactta ccaccgatct acaagggttg atccctgttt ttaccatcaa tcatcaccct   4740

gtggtgcaac acttgaaaga cccggctaga ggcactatgg acttcaggat ccactagaca   4800

gttttcagtt tgcttggagg tagctgggta atcaaaaatg tttagtcatt gattcaatgt   4860

gaacgattac ggtctttatg accaagagtc tgaaaatctt tttgttatgc tgtttagtat   4920

tcgtttgata ttgttacttt tcacctgttg agcccaaatt caggattggt tcagtggcag   4980

caatgaagtt gccatttaaa tttgttcata gcctacatca ccaaggtctc tgtgtcaaac   5040

ctgtggccac tctatatgca ctttgtttac tctttataca aataaatata ctaaagactt   5100

tacatgca                                                            5108


<210>  6468
<211>  1154
<212>  PRT
<213>  Homosapiens

<400>  6468

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys 
            340                 345                 350         


Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr 
        355                 360                 365             


Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 
    370                 375                 380                 


Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 
                405                 410                 415     


Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 
            420                 425                 430         


Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr 
        435                 440                 445             


Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 
    450                 455                 460                 


Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 
465                 470                 475                 480 


Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 
                485                 490                 495     


Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser 
            500                 505                 510         


Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys 
        515                 520                 525             


Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys 
    530                 535                 540                 


Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp 
                565                 570                 575     


Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 
            580                 585                 590         


Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 
        595                 600                 605             


Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 
    610                 615                 620                 


Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser 
625                 630                 635                 640 


Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val 
                645                 650                 655     


Cys Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly 
            660                 665                 670         


Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr 
        675                 680                 685             


Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr 
    690                 695                 700                 


Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu 
705                 710                 715                 720 


Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys 
                725                 730                 735     


Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys 
            740                 745                 750         


Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys 
        755                 760                 765             


Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp 
    770                 775                 780                 


Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile 
785                 790                 795                 800 


Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser 
                805                 810                 815     


Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro 
            820                 825                 830         


Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu 
        835                 840                 845             


Glu Glu Gln Asn Pro Asp Ile Val Ser Glu Lys Lys Pro Ala Thr Glu 
    850                 855                 860                 


Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp 
865                 870                 875                 880 


Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro 
                885                 890                 895     


Glu Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro 
            900                 905                 910         


Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile 
        915                 920                 925             


Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys 
    930                 935                 940                 


Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro 
945                 950                 955                 960 


Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn 
                965                 970                 975     


Leu Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp 
            980                 985                 990         


Tyr Leu Gly Ser Arg Gln Tyr Val  His Arg Asp Leu Ala  Ala Arg Asn 
        995                 1000                 1005             


Val Leu  Val Glu Ser Glu His  Gln Val Lys Ile Gly  Asp Phe Gly 
    1010                 1015                 1020             


Leu Thr  Lys Ala Ile Glu Thr  Asp Lys Glu Tyr Tyr  Thr Val Lys 
    1025                 1030                 1035             


Asp Asp  Arg Asp Ser Pro Val  Phe Trp Tyr Ala Pro  Glu Cys Leu 
    1040                 1045                 1050             


Met Gln  Ser Lys Phe Tyr Ile  Ala Ser Asp Val Trp  Ser Phe Gly 
    1055                 1060                 1065             


Val Thr  Leu His Glu Leu Leu  Thr Tyr Cys Asp Ser  Asp Ser Ser 
    1070                 1075                 1080             


Pro Met  Ala Leu Phe Leu Lys  Met Ile Gly Pro Thr  His Gly Gln 
    1085                 1090                 1095             


Met Thr  Val Thr Arg Leu Val  Asn Thr Leu Lys Glu  Gly Lys Arg 
    1100                 1105                 1110             


Leu Pro  Cys Pro Pro Asn Cys  Pro Asp Glu Val Tyr  Gln Leu Met 
    1115                 1120                 1125             


Arg Lys  Cys Trp Glu Phe Gln  Pro Ser Asn Arg Thr  Ser Phe Gln 
    1130                 1135                 1140             


Asn Leu  Ile Glu Gly Phe Glu  Ala Leu Leu Lys 
    1145                 1150                 


<210>  6469
<211>  5055
<212>  DNA
<213>  Homosapiens

<400>  6469
agttcagagt taggcaaaca gaggtgagca ttttgtgcca gtccttcacg tacagacagg     60

ttaaaaccga tctacacaat aatttgcaaa taaggtctgc tttgctccct ctagaaccag    120

ggaccccact cccatgccga cagtatgggc tgctgtcttc aggaccattg caagcgcttc    180

tctgaagtag ctttggaaag tagagaagaa aatccagttt gcttcttgga gaacactgga    240

cagctgaata aatgcagtat ctaaatataa aagaggactg caatgccatg gctttctgtg    300

ctaaaatgag gagctccaag aagactgagg tgaacctgga ggcccctgag ccaggggtgg    360

aagtgatctt ctatctgtcg gacagggagc ccctccggct gggcagtgga gagtacacag    420

cagaggaact gtgcatcagg gctgcacagg catgccgtat ctctcctctt tgtcacaacc    480

tctttgccct gtatgacgag aacaccaagc tctggtatgc tccaaatcgc accatcaccg    540

ttgatgacaa gatgtccctc cggctccact accggatgag gttctatttc accaattggc    600

atggaaccaa cgacaatgag cagtcagtgt ggcgtcattc tccaaagaag cagaaaaatg    660

gctacgagaa aaaaaagatt ccagatgcaa cccctctcct tgatgccagc tcactggagt    720

atctgtttgc tcagggacag tatgatttgg tgaaatgcct ggctcctatt cgagacccca    780

agaccgagca ggatggacat gatattgaga acgagtgtct agggatggct gtcctggcca    840

tctcacacta tgccatgatg aagaagatgc agttgccaga actgcccaag gacatcagct    900

acaagcgata tattccagaa acattgaata agtccatcag acagaggaac cttctcacca    960

ggatgcggat aaataatgtt ttcaaggatt tcctaaagga atttaacaac aagaccattt   1020

gtgacagcag cgtgtccacg catgacctga aggtgaaata cttggctacc ttggaaactt   1080

tgacaaaaca ttacggtgct gaaatatttg agacttccat gttactgatt tcatcagaaa   1140

atgagatgaa ttggtttcat tcgaatgacg gtggaaacgt tctctactac gaagtgatgg   1200

tgactgggaa tcttggaatc cagtggaggc ataaaccaaa tgttgtttct gttgaaaagg   1260

aaaaaaataa actgaagcgg aaaaaactgg aaaataaaca caagaaggat gaggagaaaa   1320

acaagatccg ggaagagtgg aacaattttt cttacttccc tgaaatcact cacattgtaa   1380

taaaggagtc tgtggtcagc attaacaagc aggacaacaa gaaaatggaa ctgaagctct   1440

cttcccacga ggaggccttg tcctttgtgt ccctggtaga tggctacttc cggctcacag   1500

cagatgccca tcattacctc tgcaccgacg tggccccccc gttgatcgtc cacaacatac   1560

agaatggctg tcatggtcca atctgtacag aatacgccat caataaattg cggcaagaag   1620

gaagcgagga ggggatgtac gtgctgaggt ggagctgcac cgactttgac aacatcctca   1680

tgaccgtcac ctgctttgag aagtctgagc aggtgcaggg tgcccagaag cagttcaaga   1740

actttcagat cgaggtgcag aagggccgct acagtctgca cggttcggac cgcagcttcc   1800

ccagcttggg agacctcatg agccacctca agaagcagat cctgcgcacg gataacatca   1860

gcttcatgct aaaacgctgc tgccagccca agccccgaga aatctccaac ctgctggtgg   1920

ctactaagaa agcccaggag tggcagcccg tctaccccat gagccagctg agtttcgatc   1980

ggatcctcaa gaaggatctg gtgcagggcg agcaccttgg gagaggcacg agaacacaca   2040

tctattctgg gaccctgatg gattacaagg atgacgaagg aacttctgaa gagaagaaga   2100

taaaagtgat cctcaaagtc ttagacccca gccacaggga tatttccctg gccttcttcg   2160

aggcagccag catgatgaga caggtctccc acaaacacat cgtgtacctc tatggcgtct   2220

gtgtccgcga cgtggagaat atcatggtgg aagagtttgt ggaagggggt cctctggatc   2280

tcttcatgca ccggaaaagc gatgtcctta ccacaccatg gaaattcaaa gttgccaaac   2340

agctggccag tgccctgagc tacttggagg ataaagacct ggtccatgga aatgtgtgta   2400

ctaaaaacct cctcctggcc cgtgagggca tcgacagtga gtgtggccca ttcatcaagc   2460

tcagtgaccc cggcatcccc attacggtgc tgtctaggca agaatgcatt gaacgaatcc   2520

catggattgc tcctgagtgt gttgaggact ccaagaacct gagtgtggct gctgacaagt   2580

ggagctttgg aaccacgctc tgggaaatct gctacaatgg cgagatcccc ttgaaagaca   2640

agacgctgat tgagaaagag agattctatg aaagccggtg caggccagtg acaccatcat   2700

gtaaggagct ggctgacctc atgacccgct gcatgaacta tgaccccaat cagaggcctt   2760

tcttccgagc catcatgaga gacattaata agcttgaaga gcagaatcca gatattgttt   2820

cagaaaaaaa accagcaact gaagtggacc ccacacattt tgaaaagcgc ttcctaaaga   2880

ggatccgtga cttgggagag ggccactttg ggaaggttga gctctgcagg tatgaccccg   2940

aaggggacaa tacaggggag caggtggctg ttaaatctct gaagcctgag agtggaggta   3000

accacatagc tgatctgaaa aaggaaatcg agatcttaag gaacctctat catgagaaca   3060

ttgtgaagta caaaggaatc tgcacagaag acggaggaaa tggtattaag ctcatcatgg   3120

aatttctgcc ttcgggaagc cttaaggaat atcttccaaa gaataagaac aaaataaacc   3180

tcaaacagca gctaaaatat gccgttcaga tttgtaaggg gatggactat ttgggttctc   3240

ggcaatacgt tcaccgggac ttggcagcaa gaaatgtcct tgttgagagt gaacaccaag   3300

tgaaaattgg agacttcggt ttaaccaaag caattgaaac cgataaggag tattacaccg   3360

tcaaggatga ccgggacagc cctgtgtttt ggtatgctcc agaatgttta atgcaatcta   3420

aattttatat tgcctctgac gtctggtctt ttggagtcac tctgcatgag ctgctgactt   3480

actgtgattc agattctagt cccatggctt tgttcctgaa aatgataggc ccaacccatg   3540

gccagatgac agtcacaaga cttgtgaata cgttaaaaga aggaaaacgc ctgccgtgcc   3600

cacctaactg tccagatgag gtttatcaac ttatgaggaa atgctgggaa ttccaaccat   3660

ccaatcggac aagctttcag aaccttattg aaggatttga agcactttta aaataagaag   3720

catgaataac atttaaattc cacagattat caagtccttc tcctgcaaca aatgcccaag   3780

tcatttttta aaaatttcta atgaaagaag tttgtgttct gtccaaaaag tcactgaact   3840

catacttcag tacatataca tgtataaggc acactgtagt gcttaatatg tgtaaggact   3900

tcctctttaa atttggtacc agtaacttag tgacacataa tgacaaccaa aatatttgaa   3960

agcacttaag cactcctcct tgtggaaaga atataccacc atttcatctg gctagttcac   4020

catcacaact gcattaccaa aaggggattt ttgaaaacga ggagttgacc aaaataatat   4080

ctgaagatga ttgcttttcc ctgctgccag ctgatctgaa atgttttgct ggcacattaa   4140

tcatagataa agaaagattg atggacttag ccctcaaatt tcagtatcta tacagtacta   4200

gaccatgcat tcttaaaata ttagatacca ggtagtatat attgtttctg tacaaaaatg   4260

actgtattct ctcaccagta ggacttaaac tttgtttctc cagtggctta gctcctgttc   4320

ctttgggtga tcactagcac ccatttttga gaaagctggt tctacatggg gggatagctg   4380

tggaatagat aatttgctgc atgttaattc tcaagaacta agcctgtgcc agtgctttcc   4440

taagcagtat acctttaatc agaactcatt cccagaacct ggatgctatt acacatgctt   4500

ttaagaaacg tcaatgtata tccttttata actctaccac tttggggcaa gctattccag   4560

cactggtttt gaatgctgta tgcaaccagt ctgaatacca catacgctgc actgttctta   4620

gagggtttcc atacttacca ccgatctaca agggttgatc cctgttttta ccatcaatca   4680

tcaccctgtg gtgcaacact tgaaagaccc ggctagaggc actatggact tcaggatcca   4740

ctagacagtt ttcagtttgc ttggaggtag ctgggtaatc aaaaatgttt agtcattgat   4800

tcaatgtgaa cgattacggt ctttatgacc aagagtctga aaatcttttt gttatgctgt   4860

ttagtattcg tttgatattg ttacttttca cctgttgagc ccaaattcag gattggttca   4920

gtggcagcaa tgaagttgcc atttaaattt gttcatagcc tacatcacca aggtctctgt   4980

gtcaaacctg tggccactct atatgcactt tgtttactct ttatacaaat aaatatacta   5040

aagactttac atgca                                                    5055


<210>  6470
<211>  1154
<212>  PRT
<213>  Homosapiens

<400>  6470

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys 
            340                 345                 350         


Asp Glu Glu Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr 
        355                 360                 365             


Phe Pro Glu Ile Thr His Ile Val Ile Lys Glu Ser Val Val Ser Ile 
    370                 375                 380                 


Asn Lys Gln Asp Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu 
385                 390                 395                 400 


Glu Ala Leu Ser Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr 
                405                 410                 415     


Ala Asp Ala His His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile 
            420                 425                 430         


Val His Asn Ile Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr 
        435                 440                 445             


Ala Ile Asn Lys Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val 
    450                 455                 460                 


Leu Arg Trp Ser Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr 
465                 470                 475                 480 


Cys Phe Glu Lys Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys 
                485                 490                 495     


Asn Phe Gln Ile Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser 
            500                 505                 510         


Asp Arg Ser Phe Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys 
        515                 520                 525             


Gln Ile Leu Arg Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys 
    530                 535                 540                 


Gln Pro Lys Pro Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Gln Glu Trp Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp 
                565                 570                 575     


Arg Ile Leu Lys Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly 
            580                 585                 590         


Thr Arg Thr His Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp 
        595                 600                 605             


Glu Gly Thr Ser Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu 
    610                 615                 620                 


Asp Pro Ser His Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser 
625                 630                 635                 640 


Met Met Arg Gln Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val 
                645                 650                 655     


Cys Val Arg Asp Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly 
            660                 665                 670         


Gly Pro Leu Asp Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr 
        675                 680                 685             


Pro Trp Lys Phe Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr 
    690                 695                 700                 


Leu Glu Asp Lys Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu 
705                 710                 715                 720 


Leu Leu Ala Arg Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys 
                725                 730                 735     


Leu Ser Asp Pro Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys 
            740                 745                 750         


Ile Glu Arg Ile Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys 
        755                 760                 765             


Asn Leu Ser Val Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp 
    770                 775                 780                 


Glu Ile Cys Tyr Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile 
785                 790                 795                 800 


Glu Lys Glu Arg Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser 
                805                 810                 815     


Cys Lys Glu Leu Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro 
            820                 825                 830         


Asn Gln Arg Pro Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu 
        835                 840                 845             


Glu Glu Gln Asn Pro Asp Ile Val Ser Glu Lys Lys Pro Ala Thr Glu 
    850                 855                 860                 


Val Asp Pro Thr His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp 
865                 870                 875                 880 


Leu Gly Glu Gly His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro 
                885                 890                 895     


Glu Gly Asp Asn Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro 
            900                 905                 910         


Glu Ser Gly Gly Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile 
        915                 920                 925             


Leu Arg Asn Leu Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys 
    930                 935                 940                 


Thr Glu Asp Gly Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro 
945                 950                 955                 960 


Ser Gly Ser Leu Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn 
                965                 970                 975     


Leu Lys Gln Gln Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp 
            980                 985                 990         


Tyr Leu Gly Ser Arg Gln Tyr Val  His Arg Asp Leu Ala  Ala Arg Asn 
        995                 1000                 1005             


Val Leu  Val Glu Ser Glu His  Gln Val Lys Ile Gly  Asp Phe Gly 
    1010                 1015                 1020             


Leu Thr  Lys Ala Ile Glu Thr  Asp Lys Glu Tyr Tyr  Thr Val Lys 
    1025                 1030                 1035             


Asp Asp  Arg Asp Ser Pro Val  Phe Trp Tyr Ala Pro  Glu Cys Leu 
    1040                 1045                 1050             


Met Gln  Ser Lys Phe Tyr Ile  Ala Ser Asp Val Trp  Ser Phe Gly 
    1055                 1060                 1065             


Val Thr  Leu His Glu Leu Leu  Thr Tyr Cys Asp Ser  Asp Ser Ser 
    1070                 1075                 1080             


Pro Met  Ala Leu Phe Leu Lys  Met Ile Gly Pro Thr  His Gly Gln 
    1085                 1090                 1095             


Met Thr  Val Thr Arg Leu Val  Asn Thr Leu Lys Glu  Gly Lys Arg 
    1100                 1105                 1110             


Leu Pro  Cys Pro Pro Asn Cys  Pro Asp Glu Val Tyr  Gln Leu Met 
    1115                 1120                 1125             


Arg Lys  Cys Trp Glu Phe Gln  Pro Ser Asn Arg Thr  Ser Phe Gln 
    1130                 1135                 1140             


Asn Leu  Ile Glu Gly Phe Glu  Ala Leu Leu Lys 
    1145                 1150                 


<210>  6471
<211>  1333
<212>  DNA
<213>  Homosapiens

<400>  6471
gggaggcggt gcgtcgctga gcgcaggccg cggcggccgc ggagtatcct ggagctgcag     60

acagtgcggg cctgcgccca gtcccggctg tcctcgccgc gacccctcct cagccctggg    120

cgcgcgcacg ctggggcccc gcggggctgg ccgcctagcg agcctgccgg tcgaccccag    180

ccagcgcagc gacggggcgc tgcctggccc aggcgcacac ggaagtgcgc ttctctgaag    240

tagctttgga aagtagagaa gaaaatccag tttgcttctt ggagaacact ggacagctga    300

ataaatgcag tatctaaata taaaagagga ctgcaatgcc atggctttct gtgctaaaat    360

gaggagctcc aagaagactg aggtgaacct ggaggcccct gagccagggg tggaagtgat    420

cttctatctg tcggacaggg agcccctccg gctgggcagt ggagagtaca cagcagagga    480

actgtgcatc agggctgcac aggcatgccg tatctctcct ctttgtcaca acctctttgc    540

cctgtatgac gagaacacca agctctggta tgctccaaat cgcaccatca ccgttgatga    600

caagatgtcc ctccggctcc actaccggat gaggttctat ttcaccaatt ggcatggaac    660

caacgacaat gagcagtcag tgtggcgtca ttctccaaag aagcagaaaa atggctacga    720

gaaaaaaaag attccagatg caacccctct ccttgatgcc agctcactgg agtatctgtt    780

tgctcaggga cagtatgatt tggtgaaatg cctggctcct attcgagacc ccaagaccga    840

gcaggatgga catgatattg agaacgagtg tctagggatg gctgtcctgg ccatctcaca    900

ctatgccatg atgaagaaga tgcagttgcc agaactgccc aaggacatca gctacaagcg    960

atatattcca gaaacattga ataagtccat cagacagagg aaccttctca ccaggatgcg   1020

gataaataat gttttcaagg atttcctaaa ggaatttaac aacaagacca tttgtgacag   1080

cagcgtgtcc acgcatgacc tgaaggtgaa atacttggct accttggaaa ctttgacaaa   1140

acattacggt gctgaaatat ttgagacttc catgttactg atttcatcag aaaatgagat   1200

gaattggttt cattcgaatg acggtggaaa cgttctctac tacgaagtga tggtgactgg   1260

gaatcttgga atccagtgga ggcataaacc aaatgttgtt tctgttgaaa aggaaaaaaa   1320

taaactgaag cgg                                                      1333


<210>  6472
<211>  342
<212>  PRT
<213>  Homosapiens

<400>  6472

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Val Asn Leu Glu Ala Pro 
            20                  25                  30          


Glu Pro Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu 
        35                  40                  45              


Arg Leu Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala 
    50                  55                  60                  


Ala Gln Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu 
65                  70                  75                  80  


Tyr Asp Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr 
                85                  90                  95      


Val Asp Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr 
            100                 105                 110         


Phe Thr Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg 
        115                 120                 125             


His Ser Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro 
    130                 135                 140                 


Asp Ala Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala 
145                 150                 155                 160 


Gln Gly Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro 
                165                 170                 175     


Lys Thr Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met 
            180                 185                 190         


Ala Val Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu 
        195                 200                 205             


Pro Glu Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr 
    210                 215                 220                 


Leu Asn Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile 
225                 230                 235                 240 


Asn Asn Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile 
                245                 250                 255     


Cys Asp Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala 
            260                 265                 270         


Thr Leu Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr 
        275                 280                 285             


Ser Met Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser 
    290                 295                 300                 


Asn Asp Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn 
305                 310                 315                 320 


Leu Gly Ile Gln Trp Arg His Lys Pro Asn Val Val Ser Val Glu Lys 
                325                 330                 335     


Glu Lys Asn Lys Leu Lys 
            340         


<210>  6473
<211>  1362
<212>  DNA
<213>  Homosapiens

<400>  6473
atgagcaaca aatccagtca aagcctgagt gaaataactg acaatcttag atcaaccctg     60

atggtcactc acgagtccag cagtttctat gcagagcacc aaacacctta cttacaaaac    120

tttgacaggc gtaattcaat gcttactgtc aacctgttgg ctgccactgg tggctgcctt    180

atgggactgt gtaaagtagc tgagttggtt gaaatactga tcctggccta cttggttatt    240

ggcctcttct gcagactctg cacaggtttt gtgcccacgt acatcggaga catctcacct    300

attggcctgc aaggtgtctt tggcactctc aaccagctgg gcattgttgt tggaattctg    360

gtggcccaga tctttgatct ggaattcatc ctggggtctg aagacctatg gcctgtgcta    420

ttaggctttc ccatctctcc tgctatgcta caaagtgcag cccttccttt ttgccctgaa    480

agtcccagat tcttgctcat taacagaaaa gaagaggaga atgctaagga gatcctccag    540

tggttgtggg gcacccagga tgtatcccaa gacatccagg agatgaaaga tgagagtgca    600

aggatggcac aagaaaagca agtcactgtg ctggagctct ttagagtatc cagctaccga    660

cagcccatca tcatttccat catgctccag ctctctcagc agctctctgt aatcaatact    720

gtgttctatt actcaacagg aatctttaag ggtgcaggtg ttcaagagcc catctgtgtc    780

accattggtg tggccctggg cgcgcgcacg ctggggcccc gcggggctgg ccgcctagcg    840

agcctgccgg tcgaccccag ccagcgcagc gacggggcgc tgcctggccc aggcgcacac    900

ggaagtgcgc gcacggcaag ttttcataaa caagcccgga gcgcgctgtc tgacatcctg    960

tttataccac cccgagatac aggcgcgggc tggagggctg acgtccctag ctccttgtac   1020

cgcgaacttg accgccagct cccggccggg gtggcagcgc agaaaggttc tgttaggaac   1080

caggcctcag gtagccagcg agaagtggga aaggagaccc tgggcgagag gaccagggaa   1140

ggggaacagt gggagagaac tacccgggga attgcgaatc ccactggaaa gggactgatt   1200

aaccgaaact ggggctggtc tctggctccc tcactccaac tccatccgcg catcgtcggc   1260

gaccgggagc atcggaggac taatagacac tcctccaaag tcactcccca gggtccctgg   1320

gatgtgggct ccttggatgt gtgtttacca cggaacttct ag                      1362


<210>  6474
<211>  453
<212>  PRT
<213>  Homosapiens

<400>  6474

Met Ser Asn Lys Ser Ser Gln Ser Leu Ser Glu Ile Thr Asp Asn Leu 
1               5                   10                  15      


Arg Ser Thr Leu Met Val Thr His Glu Ser Ser Ser Phe Tyr Ala Glu 
            20                  25                  30          


His Gln Thr Pro Tyr Leu Gln Asn Phe Asp Arg Arg Asn Ser Met Leu 
        35                  40                  45              


Thr Val Asn Leu Leu Ala Ala Thr Gly Gly Cys Leu Met Gly Leu Cys 
    50                  55                  60                  


Lys Val Ala Glu Leu Val Glu Ile Leu Ile Leu Ala Tyr Leu Val Ile 
65                  70                  75                  80  


Gly Leu Phe Cys Arg Leu Cys Thr Gly Phe Val Pro Thr Tyr Ile Gly 
                85                  90                  95      


Asp Ile Ser Pro Ile Gly Leu Gln Gly Val Phe Gly Thr Leu Asn Gln 
            100                 105                 110         


Leu Gly Ile Val Val Gly Ile Leu Val Ala Gln Ile Phe Asp Leu Glu 
        115                 120                 125             


Phe Ile Leu Gly Ser Glu Asp Leu Trp Pro Val Leu Leu Gly Phe Pro 
    130                 135                 140                 


Ile Ser Pro Ala Met Leu Gln Ser Ala Ala Leu Pro Phe Cys Pro Glu 
145                 150                 155                 160 


Ser Pro Arg Phe Leu Leu Ile Asn Arg Lys Glu Glu Glu Asn Ala Lys 
                165                 170                 175     


Glu Ile Leu Gln Trp Leu Trp Gly Thr Gln Asp Val Ser Gln Asp Ile 
            180                 185                 190         


Gln Glu Met Lys Asp Glu Ser Ala Arg Met Ala Gln Glu Lys Gln Val 
        195                 200                 205             


Thr Val Leu Glu Leu Phe Arg Val Ser Ser Tyr Arg Gln Pro Ile Ile 
    210                 215                 220                 


Ile Ser Ile Met Leu Gln Leu Ser Gln Gln Leu Ser Val Ile Asn Thr 
225                 230                 235                 240 


Val Phe Tyr Tyr Ser Thr Gly Ile Phe Lys Gly Ala Gly Val Gln Glu 
                245                 250                 255     


Pro Ile Cys Val Thr Ile Gly Val Ala Leu Gly Ala Arg Thr Leu Gly 
            260                 265                 270         


Pro Arg Gly Ala Gly Arg Leu Ala Ser Leu Pro Val Asp Pro Ser Gln 
        275                 280                 285             


Arg Ser Asp Gly Ala Leu Pro Gly Pro Gly Ala His Gly Ser Ala Arg 
    290                 295                 300                 


Thr Ala Ser Phe His Lys Gln Ala Arg Ser Ala Leu Ser Asp Ile Leu 
305                 310                 315                 320 


Phe Ile Pro Pro Arg Asp Thr Gly Ala Gly Trp Arg Ala Asp Val Pro 
                325                 330                 335     


Ser Ser Leu Tyr Arg Glu Leu Asp Arg Gln Leu Pro Ala Gly Val Ala 
            340                 345                 350         


Ala Gln Lys Gly Ser Val Arg Asn Gln Ala Ser Gly Ser Gln Arg Glu 
        355                 360                 365             


Val Gly Lys Glu Thr Leu Gly Glu Arg Thr Arg Glu Gly Glu Gln Trp 
    370                 375                 380                 


Glu Arg Thr Thr Arg Gly Ile Ala Asn Pro Thr Gly Lys Gly Leu Ile 
385                 390                 395                 400 


Asn Arg Asn Trp Gly Trp Ser Leu Ala Pro Ser Leu Gln Leu His Pro 
                405                 410                 415     


Arg Ile Val Gly Asp Arg Glu His Arg Arg Thr Asn Arg His Ser Ser 
            420                 425                 430         


Lys Val Thr Pro Gln Gly Pro Trp Asp Val Gly Ser Leu Asp Val Cys 
        435                 440                 445             


Leu Pro Arg Asn Phe 
    450             


<210>  6475
<211>  2804
<212>  DNA
<213>  Homosapiens

<400>  6475
taatcaaaca ttttcccaaa cttaagaaaa acaccaagaa ggaatataag tacaggggac     60

attagaggat aagctcataa gggctggact aaatcttttt tttttttttt ttttttgaga    120

cagaatctcg gaatctcgct ctgtcgccca ggctggagtg cagtggtgca atcttggctc    180

actgcaagct ccacctcctg gattcctgcc attctcctgc ctcagcctcc cgagtagctg    240

ggactacagg cacctgccac catggtgggc caattttttg tatttttggt agagatgggg    300

tttcaccatg ttagccagga tggtctcgat ctcctgacct catgattcgc ccgcctcggc    360

ctcccaacgt gctgggatta caggcgtgag ccaccgcgcc tggcctaaat cttttaagga    420

gactcagtct ttgtggcctg acacttgggg aacagtcagc ttcaggaagt tgggatgcca    480

cacctttgtt tcttgaacca tttagggagg tgtttcttga accattttga aatcagaagt    540

gtgagtcctc cagccctgac ttttttttca agattgtttt ggctatttca ggtcccttgc    600

aatcccatat gaatttttta ttttttattt tttgagaccg actctcactc tgttgcccag    660

gctggagtgc ggttgcatga tctcagctca ctgcaagctc cacctcccgg gttcaagtga    720

ttcttgtgcc tcagcctcct gagtagcttg gactacagac gtgagccacc atgtccagct    780

aattcttgta tttttagtag aggcgggctt tcacgacgtt ggccaggctg atctcgaact    840

cctgacctca ggggatacgc ccgcctcggc ctcccaaagt gctgagattt tggtgtgaac    900

caatgcgcct ggccacaatc acatatgaat ttgaggatat gctttttcca ttgagcaaaa    960

aagctattgg gatttttata gggattgtgt tgaatctgta cattgttttg ggtattgtca   1020

tcttaacaat actaagtctt ccagtttatg aatgtgggta acttctaatt tatttatttc   1080

ttcattaatc tctttcagca atgtttttac agttttcagt gtataatatt tacttctttg   1140

gataaattta ttcctaagta tcttatactt tttgatgcga ttgtaatgca gatagaattg   1200

ctttatttcc ttttcaaata tccactgctg atgtatagac aactgatttt tgtgtgttga   1260

ttttataacc tgcaactttg ttgaattcat ttattagttc aagtaggttt cttgtagatt   1320

ctttggtcgt agagatacag ttttacttct ttctttccca tttggatgct ctttctttct   1380

gcttcctgtc aacttgctct ggctagaatt ttcagtagga tgttgaatag cagttttgaa   1440

agcaggcatc tgcattcctg gtgatcaaac taattaaatt aaaatacatg taattattta   1500

gtttgagaca attagattta aatggctagg ttagggcctt aatccaatat gattggtttc   1560

tgtataagaa gaagaaatat cacagtgtgc atgcacagaa gtacgaccat gtgaagaggt   1620

agcaagagag cagcaatcta caagccaagg aaagaggcca cagaggaaac caaccctgcc   1680

agcatcttga tcttggactt ccagcttcca gaactaacca gggaccccac tcccatgccg   1740

acagtatggg ctgctgtctt caggaccatt gcaagatgtc agagctgcag catgatctgg   1800

aggctttcct cgctttcttc tgcttcccct cccttgatcc ttcacaggca ttttcctcaa   1860

tacatctctt gcctggctaa tcctgtctga tgagtttcca gatggacctg aattaaaatc   1920

ttgttctgct gcccaggctg gagtgcagtg gcacaatcat ggctcactgt ggcctctacc   1980

ttctgggctc aagtaatcct cctgcctcag cctcctcagt agctaggact acagatgcat   2040

gccaccatgc ccagctagtt tttaaatttt ttatagagtc cagggtctcc ctatgttgcc   2100

caggctggtc ttgaactcct ggcctcaagc attcctccca ccttagcctc caaaagtgct   2160

ggagttacag gcgtgagcca ccacccagcc tatgcaaata atttttaaac aataaatatt   2220

aaatggtttt gtttcttttg gagacagggt ctcactctat cactcaggct ggagtgcagt   2280

ggtgggatcg tggctcatgg cagcttcaac ctcccaggct caagcgatcc tcccacctca   2340

gcctactgag tagctgggac tacaggcaca agccaccaca cctggctaat ttttgtattt   2400

tttgcagaga tggagttttg tcatgttgct caggctggtc tcaaactcct gagctcaagt   2460

gatccacccg ccttgacctc ccaaagtgct gggattaccg gcatgagcca ctgcatgcag   2520

cctaaactgt atattaaaac gactgcttta gaacacagtc acagaaatgg gattgagtca   2580

aatggactgt ataattttag attaattcat agattagtat tggcaagtta ctttctattc   2640

agtttccaca aatctacact gccctgaaaa gcatacaccc tatcagggtc taaaacagtg   2700

gacattataa tttttcaaat agtttgtacc tttaatgttt taaaaatgta tcttgtagct   2760

ttaatttgaa tttttacatt tattaaagaa gttaatgatt ttct                    2804


<210>  6476
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  6476

Met Pro Thr Val Trp Ala Ala Val Phe Arg Thr Ile Ala Arg Cys Gln 
1               5                   10                  15      


Ser Cys Ser Met Ile Trp Arg Leu Ser Ser Leu Ser Ser Ala Ser Pro 
            20                  25                  30          


Pro Leu Ile Leu His Arg His Phe Pro Gln Tyr Ile Ser Cys Leu Ala 
        35                  40                  45              


Asn Pro Val 
    50      


<210>  6477
<211>  380
<212>  DNA
<213>  Homosapiens

<400>  6477
atgtgaagag gtagcaagag agcagcaatc tacaagccaa ggaaagaggc cacagaggaa     60

accaaccctg ccagcatctt gatcttggac ttccagcttc cagaactaac cagggacccc    120

actcccatgc cgacagtatg ggctgctgtc ttcaggacca ttgcaagtgt ccttcacggt    180

tcggttcaca tttcacaagc cccatgaagt ctatctggat tttcgatgga tgtcttgcct    240

tttcctctac acactacagg aagagtggcc acccctgcca agggcctagt atagtaccct    300

atacatgtag ctgatcagtt gattgttact gatcatatgt atcctgcatc atgttataaa    360

aaattaacac agtgcttggc                                                380


<210>  6478
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  6478

Met Gly Cys Cys Leu Gln Asp His Cys Lys Cys Pro Ser Arg Phe Gly 
1               5                   10                  15      


Ser His Phe Thr Ser Pro Met Lys Ser Ile Trp Ile Phe Asp Gly Cys 
            20                  25                  30          


Leu Ala Phe Ser Ser Thr His Tyr Arg Lys Ser Gly His Pro Cys Gln 
        35                  40                  45              


Gly Pro Ser Ile Val Pro Tyr Thr Cys Ser 
    50                  55              


<210>  6479
<211>  1156
<212>  DNA
<213>  Homosapiens

<400>  6479
aaacaggctc caaaagcttg ttacttgctt gtagtcaaac agaaggcaga gctgcgaatc     60

aaatccaggt ttgtctcgac atgccactag ctcatacttc ccttggatca gccactaaat    120

ggctttcact ccagtgagca gcgaccagca ccagaattat ggaacattta tcaacagcct    180

aaaataaaga caacacgagg agaatttggt tgcttatata gattcaaggt acaatcctgc    240

tggattctgg aagaaatatc acagtgtgca tgcacagaag tacgaccatg tgaagaggta    300

gcaagagagc agcaatctac aagccaagga aagaggccac agaggaaacc aaccctgcca    360

gcatcttgat cttggacttc cagcttccag aactaaccag ggaccccact cccatgccga    420

cagtatgggc tgctgtcttc aggaccattg caaggctgca ggaagactta gaggcatcat    480

cctgccttgg cttctggttg ccaaggtgtt ctgcctgata ccaactttgt cagcagtcac    540

caactagcca tgcttttccc ttgaaggcac atgtagattg cctaaccatc cacaccaggc    600

aaacaattct tcaaatgtca tgccctttgc acttctgttc agatccagcc ttagagaagc    660

ttgtgaagca atgactgttt taattggtct cctgggtacc caggcctaat cctttaccaa    720

gtcactagtt atcccatgtt ccttatctgt ctgtctatcc atctatcctt ccatcctcat    780

ccaatactta cagaatgcct atggctgcaa atacaaggat gactgcttgg ttcctgctgt    840

ccataaactc acagcctggg ataagtgtcc ttcacggttc ggttcacatt tcacaagccc    900

catgaagtct atctggattt tcggtaatgt ttcctgtctc tgaaatctta tgacatttat    960

gtctgtatca gccatttgat gcttgattat ctatttttca gatggatgtc ttgccttttc   1020

ctctacacac tacaggaaga gtggccaccc ctgccaaggg cctagtatag taccctatac   1080

atgtagctga tcagttgatt gttactgatc atatgtatcc tgcatcatgt tataaaaaat   1140

taacacagtg cttggc                                                   1156


<210>  6480
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  6480

Met Gly Cys Cys Leu Gln Asp His Cys Lys Ala Ala Gly Arg Leu Arg 
1               5                   10                  15      


Gly Ile Ile Leu Pro Trp Leu Leu Val Ala Lys Val Phe Cys Leu Ile 
            20                  25                  30          


Pro Thr Leu Ser Ala Val Thr Asn 
        35                  40  


<210>  6481
<211>  791
<212>  DNA
<213>  Homosapiens

<400>  6481
cagaaggcag agctgcgaat caaatccagc accagaatta tggaacattt atcaacagcc     60

taaaataaag acaacacgag gagaatttgg ttgcttatat agattcaagg tacaatcctg    120

ctggattctg ggattacagg actgtagaca aaagagaaat catcatggac tgttcactgg    180

acaaaatttc atggagagga gaagaccttt ggcggttcat ggatgttcta taataagtta    240

ggtaactaac aggctaactt tcttgagcac ctacactgtg tagggcactg tactggtact    300

tctcatacct tctctcattc atataatcct ctgaggtagg tgttatcctc tctacagcag    360

ggaaaatcaa tacccagaga aggggagaga cgtccatggc acacaggaga ggacagagcc    420

aagaatgaat ataggacacc agtgccccaa ctcttaacca ctaccataca cggttttata    480

aagtaaattt taaaagtcga ctttaaaaca tgtatgcaac attgtgtcca gtctcccaaa    540

acaaaagaac aatgagcgtt cccttttccc ttgatgtgtg ggcaggtctg tagagtagta    600

caagaagaga ttatgttctg cattctcact tcaacaagaa agtcctggtc caccaataat    660

acctttaagc ttcaggataa ttgtgaaaag gccaactagt taatcaaaca ttttcccaaa    720

cttaagaaaa acaccaagaa ggaatataag tacaggggac attagaggat aagctcataa    780

gggctggact a                                                         791


<210>  6482
<211>  41
<212>  PRT
<213>  Homosapiens

<400>  6482

Met Cys Gly Gln Val Cys Arg Val Val Gln Glu Glu Ile Met Phe Cys 
1               5                   10                  15      


Ile Leu Thr Ser Thr Arg Lys Ser Trp Ser Thr Asn Asn Thr Phe Lys 
            20                  25                  30          


Leu Gln Asp Asn Cys Glu Lys Ala Asn 
        35                  40      


<210>  6483
<211>  531
<212>  DNA
<213>  Homosapiens

<400>  6483
gtaatcacat cgaacacaat gctttgtcac ctttttcctt tgaatcaaat atcatggaaa     60

aatattttcc atacgtgttt ttaaatcact acttcgtatt ccattgtaca tttatttaac    120

caaagcccta ttgaataact taaaaattgt gtccggaagt attgctattt aaacaggact    180

ggagtgtgca gctttgtagt tatttttttt ttttttaaga gatggggtct ctctcaccca    240

agtgcactcc agcctgttga cagagtgaga ctccatctta aaaaaaaaaa aaaaacttat    300

gattctctcc cccaaccccc agtattttcc cagactttct ataatgttta tttaccaaaa    360

attgcttgag tgcccatcac atgccagaca tgccagaata tagagatgga tacattatag    420

cacagacctg aaaaaaatac actgtagttc aaggtgccgt agatactgtt agagaaagct    480

ttgggcagcc aggtgcccac ccagtttggg gaggatcctg aagaaccagt a             531


<210>  6484
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  6484

Met Ile Leu Ser Pro Asn Pro Gln Tyr Phe Pro Arg Leu Ser Ile Met 
1               5                   10                  15      


Phe Ile Tyr Gln Lys Leu Leu Glu Cys Pro Ser His Ala Arg His Ala 
            20                  25                  30          


Arg Ile 
        


<210>  6485
<211>  953
<212>  DNA
<213>  Homosapiens

<400>  6485
gggcagcggc ggcagctgag actccggggg atgtgacagc cgccggggag gggacgagac     60

gcagaccaca cgttgcccac gtgcgaggac cgggcagggg ctcagcccct aggccgcccg    120

gtgcgtgggg cggcgggggc tggctttgag tcacccccgc ttgtgccagc ttccccggct    180

cggcggagac tggcttgggg atgcctggcc gcccggcccc cttctcggac gcggcgtggg    240

gagcgagctg gagttaagga tgaaggggcg gccggcgagt cccagtgaga gcggagggtg    300

ccagaggtag ggggccgaga aacaaagttc ccggggcttc ctccggggcc gcggtcgggg    360

ctgcgcgttt gaccgccccc ctcctcgcga aggcaatggc ttccaaactc ctgcgcgcgg    420

tcatcctcgg gccgcccggc tcgggcaagg gcaccgtgtg ccagaggatc gcccagaact    480

ttggtctcca gcatctctcc agcggccact tcttgcggga gaacatcaag gccagcaccg    540

aagttggtga gatggcaaag cagtatatag agaaaagtct tttggttcca gaccatgtga    600

tcacacgcct aatgatgtcc gagttggaga acaggcgtgg ccagcactgg ctccttgatg    660

gttttcctag gacattagga caagccgaag ccctggacaa aatctgtgaa gtggatctag    720

tgatcagttt gaatattcca tttgaaacac ttaaagatcg tctcagccgc cgttggattc    780

accctcctag cggaagggta tataacctgg acttcaatcc acctcatgta catggtattg    840

atgacgtcac tggtgaaccg ttagtccagc aggaggatga taaacccgaa gcagttgctg    900

ccaggctaag acagtacaaa gacgtggcaa agccagtcat tgaattatac aag           953


<210>  6486
<211>  185
<212>  PRT
<213>  Homosapiens

<400>  6486

Met Ala Ser Lys Leu Leu Arg Ala Val Ile Leu Gly Pro Pro Gly Ser 
1               5                   10                  15      


Gly Lys Gly Thr Val Cys Gln Arg Ile Ala Gln Asn Phe Gly Leu Gln 
            20                  25                  30          


His Leu Ser Ser Gly His Phe Leu Arg Glu Asn Ile Lys Ala Ser Thr 
        35                  40                  45              


Glu Val Gly Glu Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val 
    50                  55                  60                  


Pro Asp His Val Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg 
65                  70                  75                  80  


Arg Gly Gln His Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln 
                85                  90                  95      


Ala Glu Ala Leu Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu 
            100                 105                 110         


Asn Ile Pro Phe Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile 
        115                 120                 125             


His Pro Pro Ser Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His 
    130                 135                 140                 


Val His Gly Ile Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu 
145                 150                 155                 160 


Asp Asp Lys Pro Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp 
                165                 170                 175     


Val Ala Lys Pro Val Ile Glu Leu Tyr 
            180                 185 


<210>  6487
<211>  552
<212>  DNA
<213>  Homosapiens

<400>  6487
ggggccgcgc gccggggaac ctgtggcgcc ggggggctcg cagcctcgcg cctctccagc     60

ccctccacgc agcctcgggc ctcggggcag agccctgggt ggctttgaaa ggcctgtctg    120

ttcgttgtcg ccttctaaga agttggtgag atggcaaagc agtatataga gaaaagtctt    180

ttggttccag accatgtgat cacacgccta atgatgtccg agttggagaa caggcgtggc    240

cagcactggc tccttgatgg ttttcctagg acattaggac aagccgaagc cctggacaaa    300

atctgtgaag tggatctagt gatcagtttg aatattccat ttgaaacact taaagatcgt    360

ctcagccgcc gttggattca ccctcctagc ggaagggtat ataacctgga cttcaatcca    420

cctcatgtac atggtattga tgacgtcact ggtgaaccgt tagtccagca ggaggatgat    480

aaacccgaag cagttgctgc caggctaaga cagtacaaag acgtggcaaa gccagtcatt    540

gaattataca ag                                                        552


<210>  6488
<211>  133
<212>  PRT
<213>  Homosapiens

<400>  6488

Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val Pro Asp His Val 
1               5                   10                  15      


Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg Arg Gly Gln His 
            20                  25                  30          


Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln Ala Glu Ala Leu 
        35                  40                  45              


Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu Asn Ile Pro Phe 
    50                  55                  60                  


Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile His Pro Pro Ser 
65                  70                  75                  80  


Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His Val His Gly Ile 
                85                  90                  95      


Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu Asp Asp Lys Pro 
            100                 105                 110         


Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp Val Ala Lys Pro 
        115                 120                 125             


Val Ile Glu Leu Tyr 
    130             


<210>  6489
<211>  1774
<212>  DNA
<213>  Homosapiens

<400>  6489
ggtgtgccca tctctttggt agggaaggag aaaggtaaga atagccatca gtgaggaagg     60

attcttggag cgaggagcca ctgtggtttt tcctgctatt taagatgttg agaccggata    120

actttagaaa gatacctgca caaacccata aatagtgctt ttataaagtt tagttcaccg    180

gaacctgagt tcagtatttg acattagctt tttgtccaaa gagttgaagc ctgctggagg    240

tctttgctca aataataaat accacatatt tccaagtgtg ttcaggtata ggcactaggt    300

actgtctgtt tacttcatgt taggcacatt acatgcattg gctaatcaaa tcctcatcaa    360

ttacatatgt aataatctaa acttgcctcc ttgtattata aatggaaata atcctgttta    420

tttaaacggg ttttcatgta cctgtaggga ttaggaaact caaatggcct ttttaatacc    480

tttccctagt ttgagctccc tgttctcttt aacagataaa acaacatatt tgcttcagcc    540

tggaatctgt ttttggtgct ttggtgcaga gacaggaaat gggcactcag agtcacactg    600

gtagttgcac actgtatcta cagagggcgt gtctcatctg tactctgctg ggttacagga    660

tttcagtagg tatttgtgtc cacctgagaa ttctgtttat tacctttcat ttgacagtgt    720

ctttcctttc tgcagttgat tttgctagag aggcaattca taaggtgagg tcctgttcat    780

agtatgactt gctttctcaa tatctccttc aatttttagt aactcttggt ctatttggtg    840

tctttaaaaa aaataaccta gtaataaaga cttcttttaa tgtggaaatg tggtctggta    900

gtaagttatt tctttccaca tgtaactgac ccaatctggt ttccaaatga gaagtgtgca    960

ggccccagag gttgagaagc catatttcaa ctgtgaaaaa aatctgcttc ctgcatctgt   1020

tgaaatatag ttgttcatac ttgccatccc ttatctttct tgtaacaatt tgcacagttc   1080

ttgccagaat aaatgccatt atctgtatgt ttcagggagt tccccaattt gatcattttt   1140

gtgtgtgtgt ggtgtgtgtg tgagagagag agatactgca gtaaaacatt tctaaaggat   1200

gaaagctctt gtatggcata gatatgaatt ccttcctctg gtaataatta ggttattccc   1260

agaagcacag tgtcattctt taaataaaag ctttcctgtt taaagctttt caaaggagca   1320

gaccaccttg aagattcccc ctagggttga tatgtgtcta attcatttta taaaaattat   1380

tcttgtcttc attttaaagc tttggctata tagtcagaaa tgtcctaaat aacaaactat   1440

tttgtattta atttagggaa gactaaaggg aagaaaaatg aaaactcagt ctttatgtaa   1500

gctccaagga tattagggct taaagggctt ttctagtttt atgagaattt tcgtgtgttt   1560

atgatgagtc agagtgcttt tcctcggtgg gacagttgct ggccctctta attttggtgt   1620

atgtgcttcc aagtatctaa acctccagtc tgatctgtat atgctatcct aactgttaat   1680

tgtattattg attatgttga ttatcttgct tgaaggttca tacttttcaa tttgatagaa   1740

ataaagtttt tttctgctta tagctagcga attc                               1774


<210>  6490
<211>  67
<212>  PRT
<213>  Homosapiens

<400>  6490

Met Gly Thr Gln Ser His Thr Gly Ser Cys Thr Leu Tyr Leu Gln Arg 
1               5                   10                  15      


Ala Cys Leu Ile Cys Thr Leu Leu Gly Tyr Arg Ile Ser Val Gly Ile 
            20                  25                  30          


Cys Val His Leu Arg Ile Leu Phe Ile Thr Phe His Leu Thr Val Ser 
        35                  40                  45              


Phe Leu Ser Ala Val Asp Phe Ala Arg Glu Ala Ile His Lys Val Arg 
    50                  55                  60                  


Ser Cys Ser 
65          


<210>  6491
<211>  5016
<212>  DNA
<213>  Homosapiens

<400>  6491
agacgcgcgg cggcggcggc gagcggtggc gctcggctcg ggcgaccgcg gcgggggagg     60

gcgcggcgca ccgatgggcg ccactgagaa gggaggccag aagagccgga agctgttttc    120

cttgcggcgg ccgtggaagg cgacccggcg gctgtggagg ccacgctcag ctcgccaggc    180

ggcgcagggt gcctcatctc cagacatgga gcccagctat gggggaggtc tctttgacat    240

ggtaaaagga ggtgcaggga ggctctttag taacctaaag gacaacttga aagacaccct    300

caaagacaca tcttctagag tgatacaatc tgtgaccagc tacacaaagg gagatttaga    360

cttcacttat gttacctcca gaattattgt gatgtccttt cctctggaca atgttgacat    420

aggattcagg aatcaggttg atgacattcg aagctttttg gattccagac atcttgacca    480

ctacacagta tacaatctgt cacctaagtc ttatcgaact gccaagtttc acagccgggt    540

ctcagaatgc agttggccca ttaggcaggc tcccagtctg cacaaccttt ttgctgtgtg    600

tcggaatatg tataactggc tactgcagaa tcccaaaaat gtctgtgttg tccactgctt    660

ggatggacgg gcggcatcat caattctggt tggtgctatg ttcattttct gtaatctcta    720

ctctactcct ggcccagcca ttcgattgct atatgcaaag cgaccaggaa ttggactttc    780

accatcccat aggagatacc tgggctatat gtgtgaccta ctggcagaca agccctaccg    840

ccctcacttc aagcctctca caattaagtc gatcactgtc agtccaatac cctttttcaa    900

caaacagagg aatggatgtc gcccttactg tgatgtactc attggagaaa ccaaaatata    960

ttcgacttgc acagattttg aacgaatgaa agaatatcgt gtccaagatg gaaaaatctt   1020

cattcccttg aacatcactg tgcaaggaga cgtggttgtt tccatgtatc acttgaggtc   1080

aaccattggg agccggctac aggctaaggt gaccaacaca cagatattcc agcttcagtt   1140

tcacactgga ttcataccac tggacacaac agttttaaag ttcaccaagc ctgagttaga   1200

tgcatgtgat gtaccagaaa aatatcctca gctatttcag gtgacactgg atgtagaact   1260

acagccccat gacaaagtaa tagacttaac tccaccatgg gaacattact gcacaaaaga   1320

tgtcaatccc agcatcctct tctcttctca ccaggaacat caagatacgc tggccttagg   1380

aggacaggct ccaatagata tccctccaga caaccccagg cattacggac aaagtggttt   1440

ctttgcctct ctctgttggc aagatcagaa atcggagaag tcattctgtg aggaggacca   1500

cgctgcccta gtgaatcagg aaagtgagca atcagatgat gaacttctga cactttccag   1560

tccgcatggc aatgccaatg gtgacaagcc tcatggagtc aagaagccca gcaaaaagtg   1620

cagctggtcc cacccaggct ggacagtcag gagtggaaga tgtgtttcat cctagtggac   1680

ctgcgtctac ccagtcaaca ccacgccgct ctgccacctc cacctctgcg tctccaaccc   1740

taagagtggg agaaggtgcc acctttgacc catttggagc accttctaaa ccatcaggtc   1800

aggatttgct gggttctttt ctgaacacat ccagtgcttc cagtgacccc tttctccagc   1860

caacaagaag tccttcgccc acagtacatg cttctagtac gcctgctgtg aacattcagc   1920

cagatgtttc tggaggttgg gactggcatg ctaaaccagg aggctttgga atgggaagca   1980

agtcagctgc caccagccca accggatcct cgcatggtac tcccacccat caaagcaaac   2040

cccagactct ggatcctttt gccgaccttg ggacactagg tagttcttcc tttgccagca   2100

aacccaccac accaactgga ttgggtggag gattcccgcc tctcagctcg ccacagaagg   2160

cgtctcccca gcctatgggt ggcgggtggc agcagggagg tgcctacaac tggcagcagc   2220

cacagcctaa gcctcagccc agcatgcccc actcctctcc ccagaaccga cccaactaca   2280

acgtgagctt ctcagccatg cctgggggcc agaacgaacg tgggaaagga tcaagtaatt   2340

tggaagggaa acaaaaagca gctgattttg aagacctact ctctggtcaa ggtttcaatg   2400

ctcacaaaga caaaaagggg cctcggacaa tagctgagat gagaaaggag gaaatggcca   2460

aggaaatgga tcctgagaaa ttaaagattc tggaatggat tgaaggcaaa gaaagaaata   2520

tcagagccct tctttccacg atgcataccg tactatgggc tggggagacc aagtggaaac   2580

cagttggcat ggcagacctg gtaacaccag agcaggtgaa gaaggtgtac aggaaggctg   2640

tcctggtggt gcacccagat aaagctactg ggcaacccta tgaacaatac gcaaagatga   2700

ttttcatgga gctcaatgat gcctggtctg aatttgaaaa ccaaggccaa aagcccttat   2760

attaatttat gagcttttcc atctctgctg cagacctgtg ctaatgctta gtgtgtgtca   2820

caattctgag gttttcgcag atgaaccaaa aactccagta acatgttttc agtactaaac   2880

cgttaagtta ctcatgaatt aatttctcat tgataaggaa tgtggatgtt tggtttctcc   2940

aaagttccca ccataaaaga tccaaagcat gagaggaact tctagtcaga tgaccttgca   3000

gaaccaccgc attccaccct gccctttggg gagcctactc agcattctac ctggggaaat   3060

ggaaaacaga ggccaccacc catgaaggca taacacccat cacattgtct gagaatagga   3120

ttaatgagca aaagttatga taatagagtt atatgatggt ttaatggttt ctagattttt   3180

cttggaaaga tataatttga gcagtggctt tatgcagact ccaagaacaa aaccaccagg   3240

tatttttttt taagtaaaaa tttactaagg cctttagcat aatactgtaa atgtcttttg   3300

gtcaagagaa ctaacaaata taaaggaact tgaaatgtgg ggagtgataa tagtccagtg   3360

attaaactac agtccagtga ttaccaccaa ctttctgact aagctaaaaa tgaatgaaaa   3420

tggtggctaa agaaaatagg gactctgaag atgtcgaaat ctttattcct ggttaggaag   3480

gtgggccgct acccttcttt ccctttagaa aactgtgatt aattaaataa aaagtcttac   3540

tactataaca actctaaacc tggtttaaat gaaacatcta attttgctgt aaggcttaat   3600

gctcttcttt tgtttagcca agaaaacatt cttagttgga aacaggtggt aaagtagttt   3660

ggcctgttca caacttatca ggaccaatat ctagtgtgga ctcagtgttc tctaggtttg   3720

tgagcagttg tggtaagaga atggaaggca acactgaata ggagttaagg gaatggcacg   3780

atcacagtga gagagctgca ctcacctgca gacccagtca gatggcttgt cagtatctgc   3840

tctgaggaac caggtcccac ctccccacaa ggcaaatcta gacccattaa attattacag   3900

tgggcttttt tgttttaaaa gtggttgggg atccacagga acgacattca tacagggaca   3960

tttgtgaaag caaagcaaga atgaatgctt tcccgatctc agactggctg gattcagatc   4020

agtgtgttgg ctggttctca ttttaagggg taagcagttt gctattctgt gactttagta   4080

gatctctttt gtgtgcacat atacaatgtg cattatacat atatattaaa tatatccaca   4140

aagcagatgg gcaaaaagat tttcatgcta atcttcaaag gttcatgctc aatattgtga   4200

aaagctttta aaagttgttt tgaaaagaca atcatttttt gtttttgttt taactttctt   4260

gtggcaagct ataccggaaa agcggcatgt caaaaatact ttaggttcta catagatctc   4320

tttctctctt ttgttttgtt tgtttgtttg ttaaagttca ttatttattt taccttttac   4380

tgacaatgtg aaactcgaag aaaatgttct ctttttaaat atacagtcat aaactgttca   4440

aggtaaccat aacaaactag gtgttattta ttaacgtatt ataaaataat gtttgatcca   4500

gtatgtgctt gtcttattta aaattggaat gtgagacatg ttgctgtgac ctgtttttct   4560

ttctcattca catttgtaga tattgtgtga actacagtat ataatgataa caattaaaag   4620

gatattctgt ggatgtcacg tattttgaaa tgatagaact acattagctt tgtatcatgt   4680

ttggataatt catcaatgtt cacagtttaa aacatcatta aacattatgt aattacaatg   4740

agaaagaatc ttacttaaat ttggagattt tcccccacat ctcttttccg gatacattat   4800

aattctggac ccctatttat ctcaaaactc ttaatatatg cagaccaaca ggtctttgca   4860

ttccttttaa ataactggtt gtgacaaagc ttgttgttga tcagattcac tgtttcatca   4920

tatttattgt aatatatttt ttgttttgta aatatgttac aacaaaatgt gattggtcta   4980

aaatatttgt aatgtatatt aaaaggttca aaaata                             5016


<210>  6492
<211>  533
<212>  PRT
<213>  Homosapiens

<400>  6492

Met Gly Ala Thr Glu Lys Gly Gly Gln Lys Ser Arg Lys Leu Phe Ser 
1               5                   10                  15      


Leu Arg Arg Pro Trp Lys Ala Thr Arg Arg Leu Trp Arg Pro Arg Ser 
            20                  25                  30          


Ala Arg Gln Ala Ala Gln Gly Ala Ser Ser Pro Asp Met Glu Pro Ser 
        35                  40                  45              


Tyr Gly Gly Gly Leu Phe Asp Met Val Lys Gly Gly Ala Gly Arg Leu 
    50                  55                  60                  


Phe Ser Asn Leu Lys Asp Asn Leu Lys Asp Thr Leu Lys Asp Thr Ser 
65                  70                  75                  80  


Ser Arg Val Ile Gln Ser Val Thr Ser Tyr Thr Lys Gly Asp Leu Asp 
                85                  90                  95      


Phe Thr Tyr Val Thr Ser Arg Ile Ile Val Met Ser Phe Pro Leu Asp 
            100                 105                 110         


Asn Val Asp Ile Gly Phe Arg Asn Gln Val Asp Asp Ile Arg Ser Phe 
        115                 120                 125             


Leu Asp Ser Arg His Leu Asp His Tyr Thr Val Tyr Asn Leu Ser Pro 
    130                 135                 140                 


Lys Ser Tyr Arg Thr Ala Lys Phe His Ser Arg Val Ser Glu Cys Ser 
145                 150                 155                 160 


Trp Pro Ile Arg Gln Ala Pro Ser Leu His Asn Leu Phe Ala Val Cys 
                165                 170                 175     


Arg Asn Met Tyr Asn Trp Leu Leu Gln Asn Pro Lys Asn Val Cys Val 
            180                 185                 190         


Val His Cys Leu Asp Gly Arg Ala Ala Ser Ser Ile Leu Val Gly Ala 
        195                 200                 205             


Met Phe Ile Phe Cys Asn Leu Tyr Ser Thr Pro Gly Pro Ala Ile Arg 
    210                 215                 220                 


Leu Leu Tyr Ala Lys Arg Pro Gly Ile Gly Leu Ser Pro Ser His Arg 
225                 230                 235                 240 


Arg Tyr Leu Gly Tyr Met Cys Asp Leu Leu Ala Asp Lys Pro Tyr Arg 
                245                 250                 255     


Pro His Phe Lys Pro Leu Thr Ile Lys Ser Ile Thr Val Ser Pro Ile 
            260                 265                 270         


Pro Phe Phe Asn Lys Gln Arg Asn Gly Cys Arg Pro Tyr Cys Asp Val 
        275                 280                 285             


Leu Ile Gly Glu Thr Lys Ile Tyr Ser Thr Cys Thr Asp Phe Glu Arg 
    290                 295                 300                 


Met Lys Glu Tyr Arg Val Gln Asp Gly Lys Ile Phe Ile Pro Leu Asn 
305                 310                 315                 320 


Ile Thr Val Gln Gly Asp Val Val Val Ser Met Tyr His Leu Arg Ser 
                325                 330                 335     


Thr Ile Gly Ser Arg Leu Gln Ala Lys Val Thr Asn Thr Gln Ile Phe 
            340                 345                 350         


Gln Leu Gln Phe His Thr Gly Phe Ile Pro Leu Asp Thr Thr Val Leu 
        355                 360                 365             


Lys Phe Thr Lys Pro Glu Leu Asp Ala Cys Asp Val Pro Glu Lys Tyr 
    370                 375                 380                 


Pro Gln Leu Phe Gln Val Thr Leu Asp Val Glu Leu Gln Pro His Asp 
385                 390                 395                 400 


Lys Val Ile Asp Leu Thr Pro Pro Trp Glu His Tyr Cys Thr Lys Asp 
                405                 410                 415     


Val Asn Pro Ser Ile Leu Phe Ser Ser His Gln Glu His Gln Asp Thr 
            420                 425                 430         


Leu Ala Leu Gly Gly Gln Ala Pro Ile Asp Ile Pro Pro Asp Asn Pro 
        435                 440                 445             


Arg His Tyr Gly Gln Ser Gly Phe Phe Ala Ser Leu Cys Trp Gln Asp 
    450                 455                 460                 


Gln Lys Ser Glu Lys Ser Phe Cys Glu Glu Asp His Ala Ala Leu Val 
465                 470                 475                 480 


Asn Gln Glu Ser Glu Gln Ser Asp Asp Glu Leu Leu Thr Leu Ser Ser 
                485                 490                 495     


Pro His Gly Asn Ala Asn Gly Asp Lys Pro His Gly Val Lys Lys Pro 
            500                 505                 510         


Ser Lys Lys Cys Ser Trp Ser His Pro Gly Trp Thr Val Arg Ser Gly 
        515                 520                 525             


Arg Cys Val Ser Ser 
    530             


<210>  6493
<211>  5743
<212>  DNA
<213>  Homosapiens

<400>  6493
cgcacaccga cttgcatgca attatcatag cccgagtgct cctccgttga gagacttcgc     60

ccccgagacc gctgactgtg aatgacaaat caaaagtcag ggttgcagaa tcagccggac    120

tttcctgctc atttgcagca gagggaggaa gcagagaatg aaagattctg aaaataaagg    180

tgcctcatct ccagacatgg agcccagcta tgggggaggt ctctttgaca tggtaaaagg    240

aggtgcaggg aggctcttta gtaacctaaa ggacaacttg aaagacaccc tcaaagacac    300

atcttctaga gtgatacaat ctgtgaccag ctacacaaag ggagatttag acttcactta    360

tgttacctcc agaattattg tgatgtcctt tcctctggac aatgttgaca taggattcag    420

gaatcaggtt gatgacattc gaagcttttt ggattccaga catcttgacc actacacagt    480

atacaatctg tcacctaagt cttatcgaac tgccaagttt cacagccggg tctcagaatg    540

cagttggccc attaggcagg ctcccagtct gcacaacctt tttgctgtgt gtcggaatat    600

gtataactgg ctactgcaga atcccaaaaa tgtctgtgtt gtccactgct tggatggacg    660

ggcggcatca tcaattctgg ttggtgctat gttcattttc tgtaatctct actctactcc    720

tggcccagcc attcgattgc tatatgcaaa gcgaccagga attggacttt caccatccca    780

taggagatac ctgggctata tgtgtgacct actggcagac aagccctacc gccctcactt    840

caagcctctc acaattaagt cgatcactgt cagtccaata ccctttttca acaaacagag    900

gaatggatgt cgcccttact gtgatgtact cattggagaa accaaaatat attcgacttg    960

cacagatttt gaacgaatga aagaatatcg tgtccaagat ggaaaaatct tcattccctt   1020

gaacatcact gtgcaaggag acgtggttgt ttccatgtat cacttgaggt caaccattgg   1080

gagccggcta caggctaagg tgaccaacac acagatattc cagcttcagt ttcacactgg   1140

attcatacca ctggacacaa cagttttaaa gttcaccaag cctgagttag atgcatgtga   1200

tgtaccagaa aaatatcctc agctatttca ggtgacactg gatgtagaac tacagcccca   1260

tgacaaagta atagacttaa ctccaccatg ggaacattac tgcacaaaag atgtcaatcc   1320

cagcatcctc ttctcttctc accaggaaca tcaagatacg ctggccttag gaggacaggc   1380

tccaatagat atccctccag acaaccccag gcattacgga caaagtggtt tctttgcctc   1440

tctctgttgg caagatcaga aatcggagaa gtcattctgt gaggaggacc acgctgccct   1500

agtgaatcag gaaagtgagc aatcagatga tgaacttctg acactttcca gtccgcatgg   1560

caatgccaat ggtgacaagc ctcatggagt caagaagccc agcaaaaagc agcaggagcc   1620

agcagcccct ccaccccctg aggatgtgga ccttttgggc ctggaagggt ctgcaatgag   1680

taacagcttc tctccgccag cggctcctcc caccaattct gaactactga gtgacctgtt   1740

tgggggtgga ggtgcagctg gtcccaccca ggctggacag tcaggagtgg aagatgtgtt   1800

tcatcctagt ggacctgcgt ctacccagtc aacaccacgc cgctctgcca cctccacctc   1860

tgcgtctcca accctaagag tgggagaagg tgccaccttt gacccatttg gagcaccttc   1920

taaaccatca ggtcaggatt tgctgggttc ttttctgaac acatccagtg cttccagtga   1980

cccctttctc cagccaacaa gaagtccttc gcccacagta catgcttcta gtacgcctgc   2040

tgtgaacatt cagccagatg tttctggagg ttgggactgg catgctaaac caggaggctt   2100

tggaatggga agcaagtcag ctgccaccag cccaaccgga tcctcgcatg gtactcccac   2160

ccatcaaagc aaaccccaga ctctggatcc ttttgccgac cttgggacac taggtagttc   2220

ttcctttgcc agcaaaccca ccacaccaac tggattgggt ggaggattcc cgcctctcag   2280

ctcgccacag aaggcgtctc cccagcctat gggtggcggg tggcagcagg gaggtgccta   2340

caactggcag cagccacagc ctaagcctca gcccagcatg ccccactcct ctccccagaa   2400

ccgacccaac tacaacgtga gcttctcagc catgcctggg ggccagaacg aacgtgggaa   2460

aggatcaagt aatttggaag ggaaacaaaa agcagctgat tttgaagacc tactctctgg   2520

tcaaggtttc aatgctcaca aagacaaaaa ggggcctcgg acaatagctg agatgagaaa   2580

ggaggaaatg gccaaggaaa tggatcctga gaaattaaag attctggaat ggattgaagg   2640

caaagaaaga aatatcagag cccttctttc cacgatgcat accgtactat gggctgggga   2700

gaccaagtgg aaaccagttg gcatggcaga cctggtaaca ccagagcagg tgaagaaggt   2760

gtacaggaag gctgtcctgg tggtgcaccc agataaagct actgggcaac cctatgaaca   2820

atacgcaaag atgattttca tggagctcaa tgatgcctgg tctgaatttg aaaaccaagg   2880

ccaaaagccc ttatattaat ttatgagctt ttccatctct gctgcagacc tgtgctaatg   2940

cttagtgtgt gtcacaattc tgaggttttc gcagatgaac caaaaactcc agtaacatgt   3000

tttcagtact aaaccgttaa gttactcatg aattaatttc tcattgataa ggaatgtgga   3060

tgtttggttt ctccaaagtt cccaccataa aagatccaaa gcatgagagg aacttctagt   3120

cagatgacct tgcagaacca ccgcattcca ccctgccctt tggggagcct actcagcatt   3180

ctacctgggg aaatggaaaa cagaggccac cacccatgaa ggcataacac ccatcacatt   3240

gtctgagaat aggattaatg agcaaaagtt atgataatag agttatatga tggtttaatg   3300

gtttctagat ttttcttgga aagatataat ttgagcagtg gctttatgca gactccaaga   3360

acaaaaccac caggtatttt tttttaagta aaaatttact aaggccttta gcataatact   3420

gtaaatgtct tttggtcaag agaactaaca aatataaagg aacttgaaat gtggggagtg   3480

ataatagtcc agtgattaaa ctacagtcca gtgattacca ccaactttct gactaagcta   3540

aaaatgaatg aaaatggtgg ctaaagaaaa tagggactct gaagatgtcg aaatctttat   3600

tcctggttag gaaggtgggc cgctaccctt ctttcccttt agaaaactgt gattaattaa   3660

ataaaaagtc ttactactat aacaactcta aacctggttt aaatgaaaca tctaattttg   3720

ctgtaaggct taatgctctt cttttgttta gccaagaaaa cattcttagt tggaaacagg   3780

tggtaaagta gtttggcctg ttcacaactt atcaggacca atatctagtg tggactcagt   3840

gttctctagg tttgtgagca gttgtggtaa gagaatggaa ggcaacactg aataggagtt   3900

aagggaatgg cacgatcaca gtgagagagc tgcactcacc tgcagaccca gtcagatggc   3960

ttgtcagtat ctgctctgag gaaccaggtc ccacctcccc acaaggcaaa tctagaccca   4020

ttaaattatt acagtgggct tttttgtttt aaaagtggtt ggggatccac aggaacgaca   4080

ttcatacagg gacatttgtg aaagcaaagc aagaatgaat gctttcccga tctcagactg   4140

gctggattca gatcagtgtg ttggctggtt ctcattttaa ggggtaagca gtttgctatt   4200

ctgtgacttt agtagatctc ttttgtgtgc acatatacaa tgtgcattat acatatatat   4260

taaatatatc cacaaagcag atgggcaaaa agattttcat gctaatcttc aaaggttcat   4320

gctcaatatt gtgaaaagct tttaaaagtt gttttgaaaa gacaatcatt ttttgttttt   4380

gttttaactt tcttgtggca agctataccg gaaaagcggc atgtcaaaaa tactttaggt   4440

tctacataga tctctttctc tcttttgttt tgtttgtttg tttgttaaag ttcattattt   4500

attttacctt ttactgacaa tgtgaaactc gaagaaaatg ttctcttttt aaatatacag   4560

tcataaactg ttcaaggtaa ccataacaaa ctaggtgtta tttattaacg tattataaaa   4620

taatgtttga tccagtatgt gcttgtctta tttaaaattg gaatgtgaga catgttgctg   4680

tgacctgttt ttctttctca ttcacatttg tagatattgt gtgaactaca gtatataatg   4740

ataacaatta aaaggatatt ctgtggatgt cacgtatttt gaaatgatag aactacatta   4800

gctttgtatc atgtttggat aattcatcaa tgttcacagt ttaaaacatc attaaacatt   4860

atgtaattac aatgagaaag aatcttactt aaatttggag attttccccc acatctcttt   4920

tccggataca ttataattct ggacccctat ttatctcaaa actcttaata tatgcagacc   4980

aacaggtctt tgcattcctt ttaaataact ggttgtgaca aagcttgttg ttgatcagat   5040

tcactgtttc atcatattta ttgtaatata ttttttgttt tgtaaatatg ttacaacaaa   5100

atgtgattgg tctaaaatat ttgtaatgta tattaaaagg ttcaaaaata tttgtataaa   5160

tctaagttat ttgggtactt gtaggaatac aatgaggagc ttgaatgcca ccttctgaca   5220

tgatttactt ttaaggaaag ttatgaggag agaatacaaa aagcatgcac caaaatgtaa   5280

tctgacagga tttctggatt tatacgtaat cactcctgcc ccaacacaca cacacacaca   5340

cacacacaca cacacacaca tgcacgcaca catgattttg attatgctac atgatatatg   5400

tttcaaaaag aattagcata gaaatcctgg tctcctagcc aaaaaaatca aaggattttc   5460

aaaaaaacga atctgtatgt tgaggcaaaa ggattgaacc tggaagtctg ggactttatc   5520

atagaaacaa agtctcagat attttagttc tttggaaaca aatgctgtaa ttcaaaagca   5580

tttgacctgt cactgtacta tctacatgtg gaagaatgtt caagttgaat cctaatgccg   5640

tgaatgaaac acagtctgtg tagggaatga gcaaaaaagt tgaattccaa ttgctttttg   5700

gccttttggc taaaataaat gtagcatcta attttatcag ttt                     5743


<210>  6494
<211>  913
<212>  PRT
<213>  Homosapiens

<400>  6494

Met Lys Asp Ser Glu Asn Lys Gly Ala Ser Ser Pro Asp Met Glu Pro 
1               5                   10                  15      


Ser Tyr Gly Gly Gly Leu Phe Asp Met Val Lys Gly Gly Ala Gly Arg 
            20                  25                  30          


Leu Phe Ser Asn Leu Lys Asp Asn Leu Lys Asp Thr Leu Lys Asp Thr 
        35                  40                  45              


Ser Ser Arg Val Ile Gln Ser Val Thr Ser Tyr Thr Lys Gly Asp Leu 
    50                  55                  60                  


Asp Phe Thr Tyr Val Thr Ser Arg Ile Ile Val Met Ser Phe Pro Leu 
65                  70                  75                  80  


Asp Asn Val Asp Ile Gly Phe Arg Asn Gln Val Asp Asp Ile Arg Ser 
                85                  90                  95      


Phe Leu Asp Ser Arg His Leu Asp His Tyr Thr Val Tyr Asn Leu Ser 
            100                 105                 110         


Pro Lys Ser Tyr Arg Thr Ala Lys Phe His Ser Arg Val Ser Glu Cys 
        115                 120                 125             


Ser Trp Pro Ile Arg Gln Ala Pro Ser Leu His Asn Leu Phe Ala Val 
    130                 135                 140                 


Cys Arg Asn Met Tyr Asn Trp Leu Leu Gln Asn Pro Lys Asn Val Cys 
145                 150                 155                 160 


Val Val His Cys Leu Asp Gly Arg Ala Ala Ser Ser Ile Leu Val Gly 
                165                 170                 175     


Ala Met Phe Ile Phe Cys Asn Leu Tyr Ser Thr Pro Gly Pro Ala Ile 
            180                 185                 190         


Arg Leu Leu Tyr Ala Lys Arg Pro Gly Ile Gly Leu Ser Pro Ser His 
        195                 200                 205             


Arg Arg Tyr Leu Gly Tyr Met Cys Asp Leu Leu Ala Asp Lys Pro Tyr 
    210                 215                 220                 


Arg Pro His Phe Lys Pro Leu Thr Ile Lys Ser Ile Thr Val Ser Pro 
225                 230                 235                 240 


Ile Pro Phe Phe Asn Lys Gln Arg Asn Gly Cys Arg Pro Tyr Cys Asp 
                245                 250                 255     


Val Leu Ile Gly Glu Thr Lys Ile Tyr Ser Thr Cys Thr Asp Phe Glu 
            260                 265                 270         


Arg Met Lys Glu Tyr Arg Val Gln Asp Gly Lys Ile Phe Ile Pro Leu 
        275                 280                 285             


Asn Ile Thr Val Gln Gly Asp Val Val Val Ser Met Tyr His Leu Arg 
    290                 295                 300                 


Ser Thr Ile Gly Ser Arg Leu Gln Ala Lys Val Thr Asn Thr Gln Ile 
305                 310                 315                 320 


Phe Gln Leu Gln Phe His Thr Gly Phe Ile Pro Leu Asp Thr Thr Val 
                325                 330                 335     


Leu Lys Phe Thr Lys Pro Glu Leu Asp Ala Cys Asp Val Pro Glu Lys 
            340                 345                 350         


Tyr Pro Gln Leu Phe Gln Val Thr Leu Asp Val Glu Leu Gln Pro His 
        355                 360                 365             


Asp Lys Val Ile Asp Leu Thr Pro Pro Trp Glu His Tyr Cys Thr Lys 
    370                 375                 380                 


Asp Val Asn Pro Ser Ile Leu Phe Ser Ser His Gln Glu His Gln Asp 
385                 390                 395                 400 


Thr Leu Ala Leu Gly Gly Gln Ala Pro Ile Asp Ile Pro Pro Asp Asn 
                405                 410                 415     


Pro Arg His Tyr Gly Gln Ser Gly Phe Phe Ala Ser Leu Cys Trp Gln 
            420                 425                 430         


Asp Gln Lys Ser Glu Lys Ser Phe Cys Glu Glu Asp His Ala Ala Leu 
        435                 440                 445             


Val Asn Gln Glu Ser Glu Gln Ser Asp Asp Glu Leu Leu Thr Leu Ser 
    450                 455                 460                 


Ser Pro His Gly Asn Ala Asn Gly Asp Lys Pro His Gly Val Lys Lys 
465                 470                 475                 480 


Pro Ser Lys Lys Gln Gln Glu Pro Ala Ala Pro Pro Pro Pro Glu Asp 
                485                 490                 495     


Val Asp Leu Leu Gly Leu Glu Gly Ser Ala Met Ser Asn Ser Phe Ser 
            500                 505                 510         


Pro Pro Ala Ala Pro Pro Thr Asn Ser Glu Leu Leu Ser Asp Leu Phe 
        515                 520                 525             


Gly Gly Gly Gly Ala Ala Gly Pro Thr Gln Ala Gly Gln Ser Gly Val 
    530                 535                 540                 


Glu Asp Val Phe His Pro Ser Gly Pro Ala Ser Thr Gln Ser Thr Pro 
545                 550                 555                 560 


Arg Arg Ser Ala Thr Ser Thr Ser Ala Ser Pro Thr Leu Arg Val Gly 
                565                 570                 575     


Glu Gly Ala Thr Phe Asp Pro Phe Gly Ala Pro Ser Lys Pro Ser Gly 
            580                 585                 590         


Gln Asp Leu Leu Gly Ser Phe Leu Asn Thr Ser Ser Ala Ser Ser Asp 
        595                 600                 605             


Pro Phe Leu Gln Pro Thr Arg Ser Pro Ser Pro Thr Val His Ala Ser 
    610                 615                 620                 


Ser Thr Pro Ala Val Asn Ile Gln Pro Asp Val Ser Gly Gly Trp Asp 
625                 630                 635                 640 


Trp His Ala Lys Pro Gly Gly Phe Gly Met Gly Ser Lys Ser Ala Ala 
                645                 650                 655     


Thr Ser Pro Thr Gly Ser Ser His Gly Thr Pro Thr His Gln Ser Lys 
            660                 665                 670         


Pro Gln Thr Leu Asp Pro Phe Ala Asp Leu Gly Thr Leu Gly Ser Ser 
        675                 680                 685             


Ser Phe Ala Ser Lys Pro Thr Thr Pro Thr Gly Leu Gly Gly Gly Phe 
    690                 695                 700                 


Pro Pro Leu Ser Ser Pro Gln Lys Ala Ser Pro Gln Pro Met Gly Gly 
705                 710                 715                 720 


Gly Trp Gln Gln Gly Gly Ala Tyr Asn Trp Gln Gln Pro Gln Pro Lys 
                725                 730                 735     


Pro Gln Pro Ser Met Pro His Ser Ser Pro Gln Asn Arg Pro Asn Tyr 
            740                 745                 750         


Asn Val Ser Phe Ser Ala Met Pro Gly Gly Gln Asn Glu Arg Gly Lys 
        755                 760                 765             


Gly Ser Ser Asn Leu Glu Gly Lys Gln Lys Ala Ala Asp Phe Glu Asp 
    770                 775                 780                 


Leu Leu Ser Gly Gln Gly Phe Asn Ala His Lys Asp Lys Lys Gly Pro 
785                 790                 795                 800 


Arg Thr Ile Ala Glu Met Arg Lys Glu Glu Met Ala Lys Glu Met Asp 
                805                 810                 815     


Pro Glu Lys Leu Lys Ile Leu Glu Trp Ile Glu Gly Lys Glu Arg Asn 
            820                 825                 830         


Ile Arg Ala Leu Leu Ser Thr Met His Thr Val Leu Trp Ala Gly Glu 
        835                 840                 845             


Thr Lys Trp Lys Pro Val Gly Met Ala Asp Leu Val Thr Pro Glu Gln 
    850                 855                 860                 


Val Lys Lys Val Tyr Arg Lys Ala Val Leu Val Val His Pro Asp Lys 
865                 870                 875                 880 


Ala Thr Gly Gln Pro Tyr Glu Gln Tyr Ala Lys Met Ile Phe Met Glu 
                885                 890                 895     


Leu Asn Asp Ala Trp Ser Glu Phe Glu Asn Gln Gly Gln Lys Pro Leu 
            900                 905                 910         


Tyr 
    


<210>  6495
<211>  514
<212>  DNA
<213>  Homosapiens

<400>  6495
accccatccc cttcatacac acctcattcc aaatgctatc ctgtcacagc agatgccaca     60

tcacttttgg ggtgggctaa gagatcaagg acatatgccg tgcccaaatt tcatctaata    120

attaaaaata cgggaagtga cacaaaaggg aaaacacagg atgctctgga aacttgttat    180

aggcagcgag tgggaaggag acctagagtc agaggaagct actactggaa agaggagcag    240

aactgagcca ggcaaatagg agagaaaatg tatttcaggc agaagaaaca gcactctgga    300

aacccaacat ctagcctttg agaatgtaaa atgaagccag gatgacacta ccaattccaa    360

gctgtgtgtg tgtgcatgca tgtgcatgta tgtgtatata tattagatgt atattttaac    420

attctgactt aacattaata ttaacatatt aatatttatt tattgaaata tttaacgtgt    480

attttaatat taaattctgg atttccaaac caga                                514


<210>  6496
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  6496

Met Leu Trp Lys Leu Val Ile Gly Ser Glu Trp Glu Gly Asp Leu Glu 
1               5                   10                  15      


Ser Glu Glu Ala Thr Thr Gly Lys Arg Ser Arg Thr Glu Pro Gly Lys 
            20                  25                  30          


<210>  6497
<211>  5358
<212>  DNA
<213>  Homosapiens

<400>  6497
gccgagctca gcccagggcg gcggcttcgc ctcgcccggc gaagcttctc tccggtggcc     60

gctccttctt ttccctcctc tttgcgtcat gtcgggcact taattttttt ttttttttaa    120

ttccttcttc agccctttcc accttccatc tcccttttcg cttcccaggt tgattatttt    180

ctcttttctc cgggcttgcc catgagcctc ctcgggagct accggaaaaa gaccagcaac    240

gatggttatg aatctttgca gctggtggac agtaacgggg acttaagtgc gggaagcggc    300

ggggttggcg gcaagcagag agtgaacgcc ggggcagcgg cgcggagtcc cgcccgacag    360

cctccggacc gcgccagcac catggacagc tcaggtgcct catctccaga catggagccc    420

agctatgggg gaggtctctt tgacatggta aaaggaggtg cagggaggct ctttagtaac    480

ctaaaggaca acttgaaaga caccctcaaa gacacatctt ctagagtgat acaatctgtg    540

accagctaca caaagggaga tttagacttc acttatgtta cctccagaat tattgtgatg    600

tcctttcctc tggacaatgt tgacatagga ttcaggaatc aggttgatga cattcgaagc    660

tttttggatt ccagacatct tgaccactac acagtataca atctgtcacc taagtcttat    720

cgaactgcca agtttcacag ccgggtctca gaatgcagtt ggcccattag gcaggctccc    780

agtctgcaca acctttttgc tgtgtgtcgg aatatgtata actggctact gcagaatccc    840

aaaaatgtct gtgttgtcca ctgcttggat ggacgggcgg catcatcaat tctggttggt    900

gctatgttca ttttctgtaa tctctactct actcctggcc cagccattcg attgctatat    960

gcaaagcgac caggaattgg actttcacca tcccatagga gatacctggg ctatatgtgt   1020

gacctactgg cagacaagcc ctaccgccct cacttcaagc ctctcacaat taagtcgatc   1080

actgtcagtc caataccctt tttcaacaaa cagaggaatg gatgtcgccc ttactgtgat   1140

gtactcattg gagaaaccaa aatatattcg acttgcacag attttgaacg aatgaaagaa   1200

tatcgtgtcc aagatggaaa aatcttcatt cccttgaaca tcactgtgca aggagacgtg   1260

gttgtttcca tgtatcactt gaggtcaacc attgggagcc ggctacaggc taaggtgacc   1320

aacacacaga tattccagct tcagtttcac actggattca taccactgga cacaacagtt   1380

ttaaagttca ccaagcctga gttagatgca tgtgatgtac cagaaaaata tcctcagcta   1440

tttcaggtga cactggatgt agaactacag ccccatgaca aagtaataga cttaactcca   1500

ccatgggaac attactgcac aaaagatgtc aatcccagca tcctcttctc ttctcaccag   1560

gaacatcaag atacgctggc cttaggagga caggctccaa tagatatccc tccagacaac   1620

cccaggcatt acggacaaag tggtttcttt gcctctctct gttggcaaga tcagaaatcg   1680

gagaagtcat tctgtgagga ggaccacgct gccctagtga atcaggaaag tgagcaatca   1740

gatgatgaac ttctgacact ttccagtccg catggcaatg ccaatggtga caagcctcat   1800

ggagtcaaga agcccagcaa aaagcagcag gagccagcag cccctccacc ccctgaggat   1860

gtggaccttt tgggcctgga agggtctgca atgagtaaca gcttctctcc gccagcggct   1920

cctcccacca attctgaact actgagtgac ctgtttgggg gtggaggtgc agctggtccc   1980

acccaggctg gacagtcagg agtggaagat gtgtttcatc ctagtggacc tgcgtctacc   2040

cagtcaacac cacgccgctc tgccacctcc acctctgcgt ctccaaccct aagagtggga   2100

gaaggtgcca cctttgaccc atttggagca ccttctaaac catcaggtca ggatttgctg   2160

ggttcttttc tgaacacatc cagtgcttcc agtgacccct ttctccagcc aacaagaagt   2220

ccttcgccca cagtacatgc ttctagtacg cctgctgtga acattcagcc agatgtttct   2280

ggaggttggg actggcatgc taaaccagga ggctttggaa tgggaagcaa gtcagctgcc   2340

accagcccaa ccggatcctc gcatggtact cccacccatc aaagcaaacc ccagactctg   2400

gatccttttg ccgaccttgg gacactaggt agttcttcct ttgccagcaa acccaccaca   2460

ccaactggat tgggtggagg attcccgcct ctcagctcgc cacagaaggc gtctccccag   2520

cctatgggtg gcgggtggca gcagggaggt gcctacaact ggcagcagcc acagcctaag   2580

cctcagccca gcatgcccca ctcctctccc cagaaccgac ccaactacaa cgtgagcttc   2640

tcagccatgc ctgggggcca gaacgaacgt gggaaaggat caagtaattt ggaagggaaa   2700

caaaaagcag ctgattttga agacctactc tctggtcaag gtttcaatgc tcacaaagac   2760

aaaaaggggc ctcggacaat agctgagatg agaaaggagg aaatggccaa ggaaatggat   2820

cctgagaaat taaagattct ggaatggatt gaaggcaaag aaagaaatat cagagccctt   2880

ctttccacga tgcataccgt actatgggct ggggagacca agtggaaacc agttggcatg   2940

gcagacctgg taacaccaga gcaggtgaag aaggtgtaca ggaaggctgt cctggtggtg   3000

cacccagata aagctactgg gcaaccctat gaacaatacg caaagatgat tttcatggag   3060

ctcaatgatg cctggtctga atttgaaaac caaggccaaa agcccttata ttaatttatg   3120

agcttttcca tctctgctgc agacctgtgc taatgcttag tgtgtgtcac aattctgagg   3180

ttttcgcaga tgaaccaaaa actccagtaa catgttttca gtactaaacc gttaagttac   3240

tcatgaatta atttctcatt gataaggaat gtggatgttt ggtttctcca aagttcccac   3300

cataaaagat ccaaagcatg agaggaactt ctagtcagat gaccttgcag aaccaccgca   3360

ttccaccctg ccctttgggg agcctactca gcattctacc tggggaaatg gaaaacagag   3420

gccaccaccc atgaaggcat aacacccatc acattgtctg agaataggat taatgagcaa   3480

aagttatgat aatagagtta tatgatggtt taatggtttc tagatttttc ttggaaagat   3540

ataatttgag cagtggcttt atgcagactc caagaacaaa accaccaggt attttttttt   3600

aagtaaaaat ttactaaggc ctttagcata atactgtaaa tgtcttttgg tcaagagaac   3660

taacaaatat aaaggaactt gaaatgtggg gagtgataat agtccagtga ttaaactaca   3720

gtccagtgat taccaccaac tttctgacta agctaaaaat gaatgaaaat ggtggctaaa   3780

gaaaataggg actctgaaga tgtcgaaatc tttattcctg gttaggaagg tgggccgcta   3840

cccttctttc cctttagaaa actgtgatta attaaataaa aagtcttact actataacaa   3900

ctctaaacct ggtttaaatg aaacatctaa ttttgctgta aggcttaatg ctcttctttt   3960

gtttagccaa gaaaacattc ttagttggaa acaggtggta aagtagtttg gcctgttcac   4020

aacttatcag gaccaatatc tagtgtggac tcagtgttct ctaggtttgt gagcagttgt   4080

ggtaagagaa tggaaggcaa cactgaatag gagttaaggg aatggcacga tcacagtgag   4140

agagctgcac tcacctgcag acccagtcag atggcttgtc agtatctgct ctgaggaacc   4200

aggtcccacc tccccacaag gcaaatctag acccattaaa ttattacagt gggctttttt   4260

gttttaaaag tggttgggga tccacaggaa cgacattcat acagggacat ttgtgaaagc   4320

aaagcaagaa tgaatgcttt cccgatctca gactggctgg attcagatca gtgtgttggc   4380

tggttctcat tttaaggggt aagcagtttg ctattctgtg actttagtag atctcttttg   4440

tgtgcacata tacaatgtgc attatacata tatattaaat atatccacaa agcagatggg   4500

caaaaagatt ttcatgctaa tcttcaaagg ttcatgctca atattgtgaa aagcttttaa   4560

aagttgtttt gaaaagacaa tcattttttg tttttgtttt aactttcttg tggcaagcta   4620

taccggaaaa gcggcatgtc aaaaatactt taggttctac atagatctct ttctctcttt   4680

tgttttgttt gtttgtttgt taaagttcat tatttatttt accttttact gacaatgtga   4740

aactcgaaga aaatgttctc tttttaaata tacagtcata aactgttcaa ggtaaccata   4800

acaaactagg tgttatttat taacgtatta taaaataatg tttgatccag tatgtgcttg   4860

tcttatttaa aattggaatg tgagacatgt tgctgtgacc tgtttttctt tctcattcac   4920

atttgtagat attgtgtgaa ctacagtata taatgataac aattaaaagg atattctgtg   4980

gatgtcacgt attttgaaat gatagaacta cattagcttt gtatcatgtt tggataattc   5040

atcaatgttc acagtttaaa acatcattaa acattatgta attacaatga gaaagaatct   5100

tacttaaatt tggagatttt cccccacatc tcttttccgg atacattata attctggacc   5160

cctatttatc tcaaaactct taatatatgc agaccaacag gtctttgcat tccttttaaa   5220

taactggttg tgacaaagct tgttgttgat cagattcact gtttcatcat atttattgta   5280

atatattttt tgttttgtaa atatgttaca acaaaatgtg attggtctaa aatatttgta   5340

atgtatatta aaaggttc                                                 5358


<210>  6498
<211>  970
<212>  PRT
<213>  Homosapiens

<400>  6498

Met Ser Leu Leu Gly Ser Tyr Arg Lys Lys Thr Ser Asn Asp Gly Tyr 
1               5                   10                  15      


Glu Ser Leu Gln Leu Val Asp Ser Asn Gly Asp Leu Ser Ala Gly Ser 
            20                  25                  30          


Gly Gly Val Gly Gly Lys Gln Arg Val Asn Ala Gly Ala Ala Ala Arg 
        35                  40                  45              


Ser Pro Ala Arg Gln Pro Pro Asp Arg Ala Ser Thr Met Asp Ser Ser 
    50                  55                  60                  


Gly Ala Ser Ser Pro Asp Met Glu Pro Ser Tyr Gly Gly Gly Leu Phe 
65                  70                  75                  80  


Asp Met Val Lys Gly Gly Ala Gly Arg Leu Phe Ser Asn Leu Lys Asp 
                85                  90                  95      


Asn Leu Lys Asp Thr Leu Lys Asp Thr Ser Ser Arg Val Ile Gln Ser 
            100                 105                 110         


Val Thr Ser Tyr Thr Lys Gly Asp Leu Asp Phe Thr Tyr Val Thr Ser 
        115                 120                 125             


Arg Ile Ile Val Met Ser Phe Pro Leu Asp Asn Val Asp Ile Gly Phe 
    130                 135                 140                 


Arg Asn Gln Val Asp Asp Ile Arg Ser Phe Leu Asp Ser Arg His Leu 
145                 150                 155                 160 


Asp His Tyr Thr Val Tyr Asn Leu Ser Pro Lys Ser Tyr Arg Thr Ala 
                165                 170                 175     


Lys Phe His Ser Arg Val Ser Glu Cys Ser Trp Pro Ile Arg Gln Ala 
            180                 185                 190         


Pro Ser Leu His Asn Leu Phe Ala Val Cys Arg Asn Met Tyr Asn Trp 
        195                 200                 205             


Leu Leu Gln Asn Pro Lys Asn Val Cys Val Val His Cys Leu Asp Gly 
    210                 215                 220                 


Arg Ala Ala Ser Ser Ile Leu Val Gly Ala Met Phe Ile Phe Cys Asn 
225                 230                 235                 240 


Leu Tyr Ser Thr Pro Gly Pro Ala Ile Arg Leu Leu Tyr Ala Lys Arg 
                245                 250                 255     


Pro Gly Ile Gly Leu Ser Pro Ser His Arg Arg Tyr Leu Gly Tyr Met 
            260                 265                 270         


Cys Asp Leu Leu Ala Asp Lys Pro Tyr Arg Pro His Phe Lys Pro Leu 
        275                 280                 285             


Thr Ile Lys Ser Ile Thr Val Ser Pro Ile Pro Phe Phe Asn Lys Gln 
    290                 295                 300                 


Arg Asn Gly Cys Arg Pro Tyr Cys Asp Val Leu Ile Gly Glu Thr Lys 
305                 310                 315                 320 


Ile Tyr Ser Thr Cys Thr Asp Phe Glu Arg Met Lys Glu Tyr Arg Val 
                325                 330                 335     


Gln Asp Gly Lys Ile Phe Ile Pro Leu Asn Ile Thr Val Gln Gly Asp 
            340                 345                 350         


Val Val Val Ser Met Tyr His Leu Arg Ser Thr Ile Gly Ser Arg Leu 
        355                 360                 365             


Gln Ala Lys Val Thr Asn Thr Gln Ile Phe Gln Leu Gln Phe His Thr 
    370                 375                 380                 


Gly Phe Ile Pro Leu Asp Thr Thr Val Leu Lys Phe Thr Lys Pro Glu 
385                 390                 395                 400 


Leu Asp Ala Cys Asp Val Pro Glu Lys Tyr Pro Gln Leu Phe Gln Val 
                405                 410                 415     


Thr Leu Asp Val Glu Leu Gln Pro His Asp Lys Val Ile Asp Leu Thr 
            420                 425                 430         


Pro Pro Trp Glu His Tyr Cys Thr Lys Asp Val Asn Pro Ser Ile Leu 
        435                 440                 445             


Phe Ser Ser His Gln Glu His Gln Asp Thr Leu Ala Leu Gly Gly Gln 
    450                 455                 460                 


Ala Pro Ile Asp Ile Pro Pro Asp Asn Pro Arg His Tyr Gly Gln Ser 
465                 470                 475                 480 


Gly Phe Phe Ala Ser Leu Cys Trp Gln Asp Gln Lys Ser Glu Lys Ser 
                485                 490                 495     


Phe Cys Glu Glu Asp His Ala Ala Leu Val Asn Gln Glu Ser Glu Gln 
            500                 505                 510         


Ser Asp Asp Glu Leu Leu Thr Leu Ser Ser Pro His Gly Asn Ala Asn 
        515                 520                 525             


Gly Asp Lys Pro His Gly Val Lys Lys Pro Ser Lys Lys Gln Gln Glu 
    530                 535                 540                 


Pro Ala Ala Pro Pro Pro Pro Glu Asp Val Asp Leu Leu Gly Leu Glu 
545                 550                 555                 560 


Gly Ser Ala Met Ser Asn Ser Phe Ser Pro Pro Ala Ala Pro Pro Thr 
                565                 570                 575     


Asn Ser Glu Leu Leu Ser Asp Leu Phe Gly Gly Gly Gly Ala Ala Gly 
            580                 585                 590         


Pro Thr Gln Ala Gly Gln Ser Gly Val Glu Asp Val Phe His Pro Ser 
        595                 600                 605             


Gly Pro Ala Ser Thr Gln Ser Thr Pro Arg Arg Ser Ala Thr Ser Thr 
    610                 615                 620                 


Ser Ala Ser Pro Thr Leu Arg Val Gly Glu Gly Ala Thr Phe Asp Pro 
625                 630                 635                 640 


Phe Gly Ala Pro Ser Lys Pro Ser Gly Gln Asp Leu Leu Gly Ser Phe 
                645                 650                 655     


Leu Asn Thr Ser Ser Ala Ser Ser Asp Pro Phe Leu Gln Pro Thr Arg 
            660                 665                 670         


Ser Pro Ser Pro Thr Val His Ala Ser Ser Thr Pro Ala Val Asn Ile 
        675                 680                 685             


Gln Pro Asp Val Ser Gly Gly Trp Asp Trp His Ala Lys Pro Gly Gly 
    690                 695                 700                 


Phe Gly Met Gly Ser Lys Ser Ala Ala Thr Ser Pro Thr Gly Ser Ser 
705                 710                 715                 720 


His Gly Thr Pro Thr His Gln Ser Lys Pro Gln Thr Leu Asp Pro Phe 
                725                 730                 735     


Ala Asp Leu Gly Thr Leu Gly Ser Ser Ser Phe Ala Ser Lys Pro Thr 
            740                 745                 750         


Thr Pro Thr Gly Leu Gly Gly Gly Phe Pro Pro Leu Ser Ser Pro Gln 
        755                 760                 765             


Lys Ala Ser Pro Gln Pro Met Gly Gly Gly Trp Gln Gln Gly Gly Ala 
    770                 775                 780                 


Tyr Asn Trp Gln Gln Pro Gln Pro Lys Pro Gln Pro Ser Met Pro His 
785                 790                 795                 800 


Ser Ser Pro Gln Asn Arg Pro Asn Tyr Asn Val Ser Phe Ser Ala Met 
                805                 810                 815     


Pro Gly Gly Gln Asn Glu Arg Gly Lys Gly Ser Ser Asn Leu Glu Gly 
            820                 825                 830         


Lys Gln Lys Ala Ala Asp Phe Glu Asp Leu Leu Ser Gly Gln Gly Phe 
        835                 840                 845             


Asn Ala His Lys Asp Lys Lys Gly Pro Arg Thr Ile Ala Glu Met Arg 
    850                 855                 860                 


Lys Glu Glu Met Ala Lys Glu Met Asp Pro Glu Lys Leu Lys Ile Leu 
865                 870                 875                 880 


Glu Trp Ile Glu Gly Lys Glu Arg Asn Ile Arg Ala Leu Leu Ser Thr 
                885                 890                 895     


Met His Thr Val Leu Trp Ala Gly Glu Thr Lys Trp Lys Pro Val Gly 
            900                 905                 910         


Met Ala Asp Leu Val Thr Pro Glu Gln Val Lys Lys Val Tyr Arg Lys 
        915                 920                 925             


Ala Val Leu Val Val His Pro Asp Lys Ala Thr Gly Gln Pro Tyr Glu 
    930                 935                 940                 


Gln Tyr Ala Lys Met Ile Phe Met Glu Leu Asn Asp Ala Trp Ser Glu 
945                 950                 955                 960 


Phe Glu Asn Gln Gly Gln Lys Pro Leu Tyr 
                965                 970 


<210>  6499
<211>  5958
<212>  DNA
<213>  Homosapiens

<400>  6499
gccgagctca gcccagggcg gcggcttcgc ctcgcccggc gaagcttctc tccggtggcc     60

gctccttctt ttccctcctc tttgcgtcat gtcgggcact taattttttt ttttttttaa    120

ttccttcttc agccctttcc accttccatc tcccttttcg cttcccaggt tgattatttt    180

ctcttttctc cgggcttgcc catgagcctc ctcgggagct accggaaaaa gaccagcaac    240

gatggttatg aatctttgca gctggtggac agtaacgggg acttaagtgc gggaagcggc    300

ggggttggcg gcaagcagag agtgaacgcc ggggcagcgg cgcggagtcc cgcccgacag    360

cctccggacc gcgccagcac catggacagc tcaggtgcct catctccaga catggagccc    420

agctatgggg gaggtctctt tgacatggta aaaggaggtg cagggaggct ctttagtaac    480

ctaaaggaca acttgaaaga caccctcaaa gacacatctt ctagagtgat acaatctgtg    540

accagctaca caaagggaga tttagacttc acttatgtta cctccagaat tattgtgatg    600

tcctttcctc tggacaatgt tgacatagga ttcaggaatc aggttgatga cattcgaagc    660

tttttggatt ccagacatct tgaccactac acagtataca atctgtcacc taagtcttat    720

cgaactgcca agtttcacag ccgggtctca gaatgcagtt ggcccattag gcaggctccc    780

agtctgcaca acctttttgc tgtgtgtcgg aatatgtata actggctact gcagaatccc    840

aaaaatgtct gtgttgtcca ctgcttggat ggacgggcgg catcatcaat tctggttggt    900

gctatgttca ttttctgtaa tctctactct actcctggcc cagccattcg attgctatat    960

gcaaagcgac caggaattgg actttcacca tcccatagga gatacctggg ctatatgtgt   1020

gacctactgg cagacaagcc ctaccgccct cacttcaagc ctctcacaat taagtcgatc   1080

actgtcagtc caataccctt tttcaacaaa cagaggaatg gatgtcgccc ttactgtgat   1140

gtactcattg gagaaaccaa aatatattcg acttgcacag attttgaacg aatgaaagaa   1200

tatcgtgtcc aagatggaaa aatcttcatt cccttgaaca tcactgtgca aggagacgtg   1260

gttgtttcca tgtatcactt gaggtcaacc attgggagcc ggctacaggc taaggtgacc   1320

aacacacaga tattccagct tcagtttcac actggattca taccactgga cacaacagtt   1380

ttaaagttca ccaagcctga gttagatgca tgtgatgtac cagaaaaata tcctcagcta   1440

tttcaggtga cactggatgt agaactacag ccccatgaca aagtaataga cttaactcca   1500

ccatgggaac attactgcac aaaagatgtc aatcccagca tcctcttctc ttctcaccag   1560

gaacatcaag atacgctggc cttaggagga caggctccaa tagatatccc tccagacaac   1620

cccaggcatt acggacaaag tggtttcttt gcctctctct gttggcaaga tcagaaatcg   1680

gagaagtcat tctgtgagga ggaccacgct gccctagtga atcaggaaag tgagcaatca   1740

gatgatgaac ttctgacact ttccagtccg catggcaatg ccaatggtga caagcctcat   1800

ggagtcaaga agcccagcaa aaagcagcag gagccagcag cccctccacc ccctgaggat   1860

gtggaccttt tgggcctgga agggtctgca atgagtaaca gcttctctcc gccagcggct   1920

cctcccacca attctgaact actgagtgac ctgtttgggg gtggaggtgc agctggtccc   1980

acccaggctg gacagtcagg agtggaagat gtgtttcatc ctagtggacc tgcgtctacc   2040

cagtcaacac cacgccgctc tgccacctcc acctctgcgt ctccaaccct aagagtggga   2100

gaaggtgcca cctttgaccc atttggagca ccttctaaac catcaggtca ggatttgctg   2160

ggttcttttc tgaacacatc cagtgcttcc agtgacccct ttctccagcc aacaagaagt   2220

ccttcgccca cagtacatgc ttctagtacg cctgctgtga acattcagcc agatgtttct   2280

ggaggttggg actggcatgc taaaccagga ggctttggaa tgggaagcaa gtcagctgcc   2340

accagcccaa ccggatcctc gcatggtact cccacccatc aaagcaaacc ccagactctg   2400

gatccttttg ccgaccttgg gacactaggt agttcttcct ttgccagcaa acccaccaca   2460

ccaactggat tgggtggagg attcccgcct ctcagctcgc cacagaaggc gtctccccag   2520

cctatgggtg gcgggtggca gcagggaggt gcctacaact ggcagcagcc acagcctaag   2580

cctcagccca gcatgcccca ctcctctccc cagaaccgac ccaactacaa cgtgagcttc   2640

tcagccatgc ctgggggcca gaacgaacgt gggaaaggat caagtaattt ggaagggaaa   2700

caaaaagcag ctgattttga agacctactc tctggtcaag gtttcaatgc tcacaaagac   2760

aaaaaggggc ctcggacaat agctgagatg agaaaggagg aaatggccaa ggaaatggat   2820

cctgagaaat taaagattct ggaatggatt gaaggcaaag aaagaaatat cagagccctt   2880

ctttccacga tgcataccgt actatgggct ggggagacca agtggaaacc agttggcatg   2940

gcagacctgg taacaccaga gcaggtgaag aaggtgtaca ggaaggctgt cctggtggtg   3000

cacccagata aagctactgg gcaaccctat gaacaatacg caaagatgat tttcatggag   3060

ctcaatgatg cctggtctga atttgaaaac caaggccaaa agcccttata ttaatttatg   3120

agcttttcca tctctgctgc agacctgtgc taatgcttag tgtgtgtcac aattctgagg   3180

ttttcgcaga tgaaccaaaa actccagtaa catgttttca gtactaaacc gttaagttac   3240

tcatgaatta atttctcatt gataaggaat gtggatgttt ggtttctcca aagttcccac   3300

cataaaagat ccaaagcatg agaggaactt ctagtcagat gaccttgcag aaccaccgca   3360

ttccaccctg ccctttgggg agcctactca gcattctacc tggggaaatg gaaaacagag   3420

gccaccaccc atgaaggcat aacacccatc acattgtctg agaataggat taatgagcaa   3480

aagttatgat aatagagtta tatgatggtt taatggtttc tagatttttc ttggaaagat   3540

ataatttgag cagtggcttt atgcagactc caagaacaaa accaccaggt attttttttt   3600

aagtaaaaat ttactaaggc ctttagcata atactgtaaa tgtcttttgg tcaagagaac   3660

taacaaatat aaaggaactt gaaatgtggg gagtgataat agtccagtga ttaaactaca   3720

gtccagtgat taccaccaac tttctgacta agctaaaaat gaatgaaaat ggtggctaaa   3780

gaaaataggg actctgaaga tgtcgaaatc tttattcctg gttaggaagg tgggccgcta   3840

cccttctttc cctttagaaa actgtgatta attaaataaa aagtcttact actataacaa   3900

ctctaaacct ggtttaaatg aaacatctaa ttttgctgta aggcttaatg ctcttctttt   3960

gtttagccaa gaaaacattc ttagttggaa acaggtggta aagtagtttg gcctgttcac   4020

aacttatcag gaccaatatc tagtgtggac tcagtgttct ctaggtttgt gagcagttgt   4080

ggtaagagaa tggaaggcaa cactgaatag gagttaaggg aatggcacga tcacagtgag   4140

agagctgcac tcacctgcag acccagtcag atggcttgtc agtatctgct ctgaggaacc   4200

aggtcccacc tccccacaag gcaaatctag acccattaaa ttattacagt gggctttttt   4260

gttttaaaag tggttgggga tccacaggaa cgacattcat acagggacat ttgtgaaagc   4320

aaagcaagaa tgaatgcttt cccgatctca gactggctgg attcagatca gtgtgttggc   4380

tggttctcat tttaaggggt aagcagtttg ctattctgtg actttagtag atctcttttg   4440

tgtgcacata tacaatgtgc attatacata tatattaaat atatccacaa agcagatggg   4500

caaaaagatt ttcatgctaa tcttcaaagg ttcatgctca atattgtgaa aagcttttaa   4560

aagttgtttt gaaaagacaa tcattttttg tttttgtttt aactttcttg tggcaagcta   4620

taccggaaaa gcggcatgtc aaaaatactt taggttctac atagatctct ttctctcttt   4680

tgttttgttt gtttgtttgt taaagttcat tatttatttt accttttact gacaatgtga   4740

aactcgaaga aaatgttctc tttttaaata tacagtcata aactgttcaa ggtaaccata   4800

acaaactagg tgttatttat taacgtatta taaaataatg tttgatccag tatgtgcttg   4860

tcttatttaa aattggaatg tgagacatgt tgctgtgacc tgtttttctt tctcattcac   4920

atttgtagat attgtgtgaa ctacagtata taatgataac aattaaaagg atattctgtg   4980

gatgtcacgt attttgaaat gatagaacta cattagcttt gtatcatgtt tggataattc   5040

atcaatgttc acagtttaaa acatcattaa acattatgta attacaatga gaaagaatct   5100

tacttaaatt tggagatttt cccccacatc tcttttccgg atacattata attctggacc   5160

cctatttatc tcaaaactct taatatatgc agaccaacag gtctttgcat tccttttaaa   5220

taactggttg tgacaaagct tgttgttgat cagattcact gtttcatcat atttattgta   5280

atatattttt tgttttgtaa atatgttaca acaaaatgtg attggtctaa aatatttgta   5340

atgtatatta aaaggttcaa aaatatttgt ataaatctaa gttatttggg tacttgtagg   5400

aatacaatga ggagcttgaa tgccaccttc tgacatgatt tacttttaag gaaagttatg   5460

aggagagaat acaaaaagca tgcaccaaaa tgtaatctga caggatttct ggatttatac   5520

gtaatcactc ctgccccaac acacacacac acacacacac acacacacac acacatgcac   5580

gcacacatga ttttgattat gctacatgat atatgtttca aaaagaatta gcatagaaat   5640

cctggtctcc tagccaaaaa aatcaaagga ttttcaaaaa aacgaatctg tatgttgagg   5700

caaaaggatt gaacctggaa gtctgggact ttatcataga aacaaagtct cagatatttt   5760

agttctttgg aaacaaatgc tgtaattcaa aagcatttga cctgtcactg tactatctac   5820

atgtggaaga atgttcaagt tgaatcctaa tgccgtgaat gaaacacagt ctgtgtaggg   5880

aatgagcaaa aaagttgaat tccaattgct ttttggcctt ttggctaaaa taaatgtagc   5940

atctaatttt atcagttt                                                 5958


<210>  6500
<211>  970
<212>  PRT
<213>  Homosapiens

<400>  6500

Met Ser Leu Leu Gly Ser Tyr Arg Lys Lys Thr Ser Asn Asp Gly Tyr 
1               5                   10                  15      


Glu Ser Leu Gln Leu Val Asp Ser Asn Gly Asp Leu Ser Ala Gly Ser 
            20                  25                  30          


Gly Gly Val Gly Gly Lys Gln Arg Val Asn Ala Gly Ala Ala Ala Arg 
        35                  40                  45              


Ser Pro Ala Arg Gln Pro Pro Asp Arg Ala Ser Thr Met Asp Ser Ser 
    50                  55                  60                  


Gly Ala Ser Ser Pro Asp Met Glu Pro Ser Tyr Gly Gly Gly Leu Phe 
65                  70                  75                  80  


Asp Met Val Lys Gly Gly Ala Gly Arg Leu Phe Ser Asn Leu Lys Asp 
                85                  90                  95      


Asn Leu Lys Asp Thr Leu Lys Asp Thr Ser Ser Arg Val Ile Gln Ser 
            100                 105                 110         


Val Thr Ser Tyr Thr Lys Gly Asp Leu Asp Phe Thr Tyr Val Thr Ser 
        115                 120                 125             


Arg Ile Ile Val Met Ser Phe Pro Leu Asp Asn Val Asp Ile Gly Phe 
    130                 135                 140                 


Arg Asn Gln Val Asp Asp Ile Arg Ser Phe Leu Asp Ser Arg His Leu 
145                 150                 155                 160 


Asp His Tyr Thr Val Tyr Asn Leu Ser Pro Lys Ser Tyr Arg Thr Ala 
                165                 170                 175     


Lys Phe His Ser Arg Val Ser Glu Cys Ser Trp Pro Ile Arg Gln Ala 
            180                 185                 190         


Pro Ser Leu His Asn Leu Phe Ala Val Cys Arg Asn Met Tyr Asn Trp 
        195                 200                 205             


Leu Leu Gln Asn Pro Lys Asn Val Cys Val Val His Cys Leu Asp Gly 
    210                 215                 220                 


Arg Ala Ala Ser Ser Ile Leu Val Gly Ala Met Phe Ile Phe Cys Asn 
225                 230                 235                 240 


Leu Tyr Ser Thr Pro Gly Pro Ala Ile Arg Leu Leu Tyr Ala Lys Arg 
                245                 250                 255     


Pro Gly Ile Gly Leu Ser Pro Ser His Arg Arg Tyr Leu Gly Tyr Met 
            260                 265                 270         


Cys Asp Leu Leu Ala Asp Lys Pro Tyr Arg Pro His Phe Lys Pro Leu 
        275                 280                 285             


Thr Ile Lys Ser Ile Thr Val Ser Pro Ile Pro Phe Phe Asn Lys Gln 
    290                 295                 300                 


Arg Asn Gly Cys Arg Pro Tyr Cys Asp Val Leu Ile Gly Glu Thr Lys 
305                 310                 315                 320 


Ile Tyr Ser Thr Cys Thr Asp Phe Glu Arg Met Lys Glu Tyr Arg Val 
                325                 330                 335     


Gln Asp Gly Lys Ile Phe Ile Pro Leu Asn Ile Thr Val Gln Gly Asp 
            340                 345                 350         


Val Val Val Ser Met Tyr His Leu Arg Ser Thr Ile Gly Ser Arg Leu 
        355                 360                 365             


Gln Ala Lys Val Thr Asn Thr Gln Ile Phe Gln Leu Gln Phe His Thr 
    370                 375                 380                 


Gly Phe Ile Pro Leu Asp Thr Thr Val Leu Lys Phe Thr Lys Pro Glu 
385                 390                 395                 400 


Leu Asp Ala Cys Asp Val Pro Glu Lys Tyr Pro Gln Leu Phe Gln Val 
                405                 410                 415     


Thr Leu Asp Val Glu Leu Gln Pro His Asp Lys Val Ile Asp Leu Thr 
            420                 425                 430         


Pro Pro Trp Glu His Tyr Cys Thr Lys Asp Val Asn Pro Ser Ile Leu 
        435                 440                 445             


Phe Ser Ser His Gln Glu His Gln Asp Thr Leu Ala Leu Gly Gly Gln 
    450                 455                 460                 


Ala Pro Ile Asp Ile Pro Pro Asp Asn Pro Arg His Tyr Gly Gln Ser 
465                 470                 475                 480 


Gly Phe Phe Ala Ser Leu Cys Trp Gln Asp Gln Lys Ser Glu Lys Ser 
                485                 490                 495     


Phe Cys Glu Glu Asp His Ala Ala Leu Val Asn Gln Glu Ser Glu Gln 
            500                 505                 510         


Ser Asp Asp Glu Leu Leu Thr Leu Ser Ser Pro His Gly Asn Ala Asn 
        515                 520                 525             


Gly Asp Lys Pro His Gly Val Lys Lys Pro Ser Lys Lys Gln Gln Glu 
    530                 535                 540                 


Pro Ala Ala Pro Pro Pro Pro Glu Asp Val Asp Leu Leu Gly Leu Glu 
545                 550                 555                 560 


Gly Ser Ala Met Ser Asn Ser Phe Ser Pro Pro Ala Ala Pro Pro Thr 
                565                 570                 575     


Asn Ser Glu Leu Leu Ser Asp Leu Phe Gly Gly Gly Gly Ala Ala Gly 
            580                 585                 590         


Pro Thr Gln Ala Gly Gln Ser Gly Val Glu Asp Val Phe His Pro Ser 
        595                 600                 605             


Gly Pro Ala Ser Thr Gln Ser Thr Pro Arg Arg Ser Ala Thr Ser Thr 
    610                 615                 620                 


Ser Ala Ser Pro Thr Leu Arg Val Gly Glu Gly Ala Thr Phe Asp Pro 
625                 630                 635                 640 


Phe Gly Ala Pro Ser Lys Pro Ser Gly Gln Asp Leu Leu Gly Ser Phe 
                645                 650                 655     


Leu Asn Thr Ser Ser Ala Ser Ser Asp Pro Phe Leu Gln Pro Thr Arg 
            660                 665                 670         


Ser Pro Ser Pro Thr Val His Ala Ser Ser Thr Pro Ala Val Asn Ile 
        675                 680                 685             


Gln Pro Asp Val Ser Gly Gly Trp Asp Trp His Ala Lys Pro Gly Gly 
    690                 695                 700                 


Phe Gly Met Gly Ser Lys Ser Ala Ala Thr Ser Pro Thr Gly Ser Ser 
705                 710                 715                 720 


His Gly Thr Pro Thr His Gln Ser Lys Pro Gln Thr Leu Asp Pro Phe 
                725                 730                 735     


Ala Asp Leu Gly Thr Leu Gly Ser Ser Ser Phe Ala Ser Lys Pro Thr 
            740                 745                 750         


Thr Pro Thr Gly Leu Gly Gly Gly Phe Pro Pro Leu Ser Ser Pro Gln 
        755                 760                 765             


Lys Ala Ser Pro Gln Pro Met Gly Gly Gly Trp Gln Gln Gly Gly Ala 
    770                 775                 780                 


Tyr Asn Trp Gln Gln Pro Gln Pro Lys Pro Gln Pro Ser Met Pro His 
785                 790                 795                 800 


Ser Ser Pro Gln Asn Arg Pro Asn Tyr Asn Val Ser Phe Ser Ala Met 
                805                 810                 815     


Pro Gly Gly Gln Asn Glu Arg Gly Lys Gly Ser Ser Asn Leu Glu Gly 
            820                 825                 830         


Lys Gln Lys Ala Ala Asp Phe Glu Asp Leu Leu Ser Gly Gln Gly Phe 
        835                 840                 845             


Asn Ala His Lys Asp Lys Lys Gly Pro Arg Thr Ile Ala Glu Met Arg 
    850                 855                 860                 


Lys Glu Glu Met Ala Lys Glu Met Asp Pro Glu Lys Leu Lys Ile Leu 
865                 870                 875                 880 


Glu Trp Ile Glu Gly Lys Glu Arg Asn Ile Arg Ala Leu Leu Ser Thr 
                885                 890                 895     


Met His Thr Val Leu Trp Ala Gly Glu Thr Lys Trp Lys Pro Val Gly 
            900                 905                 910         


Met Ala Asp Leu Val Thr Pro Glu Gln Val Lys Lys Val Tyr Arg Lys 
        915                 920                 925             


Ala Val Leu Val Val His Pro Asp Lys Ala Thr Gly Gln Pro Tyr Glu 
    930                 935                 940                 


Gln Tyr Ala Lys Met Ile Phe Met Glu Leu Asn Asp Ala Trp Ser Glu 
945                 950                 955                 960 


Phe Glu Asn Gln Gly Gln Lys Pro Leu Tyr 
                965                 970 


<210>  6501
<211>  1892
<212>  DNA
<213>  Homosapiens

<400>  6501
gcgctggtgt gggttagggc tgagaaagaa cgacaggaac agagacgtcg cgaggattaa     60

gtttaagact tcgcgagaac agaatttctt ttggcacctc ctctccgcgc gttcttgggg    120

gttgaaagga ggagcaggag gtactgatgg acaaggaggt accttccggt acacctttca    180

tggcgatcct catgctacat ttgctgcatt tttcggaggg tccaacccct ttgaaatttt    240

ctttggaaga cgaatgggtg gtggtagaga ttctgaagaa atggaaatag atggtgatcc    300

ttttagtgcc tttggtttca gcatgaatgg atatccaaga gacaggaatt ctgtggggcc    360

atcccgcctc aaacaagatc ctccagttat tcatgaactt agagtatcac ttgaagagat    420

atatagtggt tgtaccaaac ggatgaagat ttctcgaaaa aggctaaacg ctgatggaag    480

gagttacaga tctgaggaca aaattcttac cattgagatt aaaaaagggt ggaaagaagg    540

caccaaaatt acttttccaa gagaaggaga tgaaacacca aatagtattc cagcagacat    600

tgtttttatc attaaagaca aagatcatcc aaaatttaaa agggatggat caaatataat    660

ttatactgct aaaattagtt tacgagaggc attgtgtggc tgctcaatta atgtaccaac    720

actggatgga agaaacatac ctatgtcagt aaatgatatt gtgaaacccg gaatgaggag    780

aagaattatt ggatatgggc tgccatttcc aaaaaatcct gaccaacgtg gtgaccttct    840

aatagaattt gaggtgtcct tcccagatac tatatcttct tcatccaaag aagtacttag    900

gaaacatctt cctgcctcat agaatgaaga actttgttac acatattttg ataaggcact    960

gaaaatataa aaggactggt agtttactga tgtagatgtg aattctgtat aaagatgtgt   1020

aaattctttt gagggttcat taaattgcat gaatagagac gggtcaaata aataggcaaa   1080

agggattttt acagttagag ataaaagaga aaaccattca ctgtatttta tttcatttct   1140

cctgattcag atatttttag taatttgctt atatgtaaaa gttgtttttg tggagtcagt   1200

ggatatattt ctaatgaagt gctagactat ccaattactt aatttcttat acctttagat   1260

aatcagtatg aaaagttccc atttataatg gaaatgaaaa ttcttaacta aactatacat   1320

gtaatatgta tttctagaag agaataaaaa cccaagtcag ttattagatt taaatcacct   1380

tctgaaatgc tgctataggg ctggtatctg taaaagaata tcctgatgca tctgtttcac   1440

cattttgatt tttaaagtat gctgtagcat ttcttaataa catcgttgtg atgttcttaa   1500

ggcagatctt tcttcataaa aaggaaagta atggcaattt ctctcctgtg gaaatcccaa   1560

ttgcttgaat tactgatatt ttagaataga ctttttaaaa tgccatatgt aattttatgc   1620

aagttgacta tatatcttgt acttaataaa ttataggctc attttgttct ctgctagttt   1680

aaagtaattc gtttaataat agatgtgttt ttagaggaaa tgctgttact tggaattaat   1740

tttccagtta tacagtcttc tataacttac taataatatt ctatatgtac tttatgtaat   1800

ttccctaaaa agaatgaact accactacac tatggtgtta aaccaaaata tagggaaaat   1860

aaacactaac tgctgcttat ggataatgtt gc                                 1892


<210>  6502
<211>  222
<212>  PRT
<213>  Homosapiens

<400>  6502

Met Gly Gly Gly Arg Asp Ser Glu Glu Met Glu Ile Asp Gly Asp Pro 
1               5                   10                  15      


Phe Ser Ala Phe Gly Phe Ser Met Asn Gly Tyr Pro Arg Asp Arg Asn 
            20                  25                  30          


Ser Val Gly Pro Ser Arg Leu Lys Gln Asp Pro Pro Val Ile His Glu 
        35                  40                  45              


Leu Arg Val Ser Leu Glu Glu Ile Tyr Ser Gly Cys Thr Lys Arg Met 
    50                  55                  60                  


Lys Ile Ser Arg Lys Arg Leu Asn Ala Asp Gly Arg Ser Tyr Arg Ser 
65                  70                  75                  80  


Glu Asp Lys Ile Leu Thr Ile Glu Ile Lys Lys Gly Trp Lys Glu Gly 
                85                  90                  95      


Thr Lys Ile Thr Phe Pro Arg Glu Gly Asp Glu Thr Pro Asn Ser Ile 
            100                 105                 110         


Pro Ala Asp Ile Val Phe Ile Ile Lys Asp Lys Asp His Pro Lys Phe 
        115                 120                 125             


Lys Arg Asp Gly Ser Asn Ile Ile Tyr Thr Ala Lys Ile Ser Leu Arg 
    130                 135                 140                 


Glu Ala Leu Cys Gly Cys Ser Ile Asn Val Pro Thr Leu Asp Gly Arg 
145                 150                 155                 160 


Asn Ile Pro Met Ser Val Asn Asp Ile Val Lys Pro Gly Met Arg Arg 
                165                 170                 175     


Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro Lys Asn Pro Asp Gln Arg 
            180                 185                 190         


Gly Asp Leu Leu Ile Glu Phe Glu Val Ser Phe Pro Asp Thr Ile Ser 
        195                 200                 205             


Ser Ser Ser Lys Glu Val Leu Arg Lys His Leu Pro Ala Ser 
    210                 215                 220         


<210>  6503
<211>  1992
<212>  DNA
<213>  Homosapiens

<400>  6503
gcgctggtgt gggttagggc tgagaaagaa cgacaggaac agagacgtcg cgaggattaa     60

gtttaagact tcgcgagaac agaatttctt ttggcacctc ctctccgcgc gttcttgggg    120

gttgaaagga ggagcaggag gtactgatgg acaaggaggt accttccggt acacctttca    180

tggcgatcct catgctacat ttgctgcatt tttcggaggg tccaacccct ttgaaatttt    240

ctttggaaga cgaatgggtg gtggtagaga ttctgaagaa atggaaatag atggtgatcc    300

ttttagtgcc tttggtttca gcatgaatgg atatccaaga gacaggaatt ctgtggggcc    360

atcccgcctc aaacaagatc ctccagttat tcatgaactt agagtatcac ttgaagagat    420

atatagtggt tgtaccaaac ggatgaagat ttctcgaaaa aggctaaacg ctgatggaag    480

gagttacaga tctgaggaca aaattcttac cattgagatt aaaaaagggt ggaaagaagg    540

caccaaaatt acttttccaa gagaaggaga tgaaacacca aatagtattc cagcagacat    600

tgtttttatc attaaagaca aagatcatcc aaaatttaaa agggatggat caaatataat    660

ttatactgct aaaattagtt tacgagaggc attgtgtggc tgctcaatta atgtaccaac    720

actggatgga agaaacatac ctatgtcagt aaatgatatt gtgaaacccg gaatgaggag    780

aagaattatt ggatatgggc tgccatttcc aaaaaatcct gaccaacgtg gtgaccttct    840

aatagaattt gaggtgtcct tcccagatac tatatcttct tcatccaaag aagtacttag    900

gaaacatctt cctgcctcat agaatgaaga actttgttac acatattttg ataaggcact    960

gaaaatataa aaggactggt agtttactga tgtagatgtg aattctgtat aaagatgtgt   1020

aaattctttt gagggttcat taaattgcat gaatagagac gggtcaaata aataggcaaa   1080

agggattttt acagttagag ataaaagaga aaaccattca ctgtatttta tttcatttct   1140

cctgattcag atatttttag taatttgctt atatgtaaaa gttgtttttg tggagtcagt   1200

ggatatattt ctaatgaagt gctagactat ccaattactt aatttcttat acctttagat   1260

aatcagtatg aaaagttccc atttataatg gaaatgaaaa ttcttaacta aactatacat   1320

gtaatatgta tttctagaag agaataaaaa cccaagtcag ttattagatt taaatcacct   1380

tctgaaatgc tgctataggg ctggtatctg taaaagaata tcctgatgca tctgtttcac   1440

cattttgatt tttaaagtat gctgtagcat ttcttaataa catcgttgtg atgttcttaa   1500

ggcagatctt tcttcataaa aaggaaagta atggcaattt ctctcctgtg gaaatcccaa   1560

ttgcttgaat tactgatatt ttagaataga ctttttaaaa tgccatatgt aattttatgc   1620

aagttgacta tatatcttgt acttaataaa ttataggctc attttgttct ctgctagttt   1680

aaagtaattc gtttaataat agatgtgttt ttagaggaaa tgctgttact tggaattaat   1740

tttccagtta tacagtcttc tataacttac taataatatt ctatatgtac tttatgtaat   1800

ttccctaaaa agaatgaact accactacac tatggtgtta aaccaaaata tagggaaaat   1860

aaacactaac tgctgcttat ggataatgtt gcaactactt gttatgcata taaatatttt   1920

actttttcac atgtatagat tgcatttctt aggtgtttta attttttaaa tatatttatg   1980

ttttaaaaat tt                                                       1992


<210>  6504
<211>  222
<212>  PRT
<213>  Homosapiens

<400>  6504

Met Gly Gly Gly Arg Asp Ser Glu Glu Met Glu Ile Asp Gly Asp Pro 
1               5                   10                  15      


Phe Ser Ala Phe Gly Phe Ser Met Asn Gly Tyr Pro Arg Asp Arg Asn 
            20                  25                  30          


Ser Val Gly Pro Ser Arg Leu Lys Gln Asp Pro Pro Val Ile His Glu 
        35                  40                  45              


Leu Arg Val Ser Leu Glu Glu Ile Tyr Ser Gly Cys Thr Lys Arg Met 
    50                  55                  60                  


Lys Ile Ser Arg Lys Arg Leu Asn Ala Asp Gly Arg Ser Tyr Arg Ser 
65                  70                  75                  80  


Glu Asp Lys Ile Leu Thr Ile Glu Ile Lys Lys Gly Trp Lys Glu Gly 
                85                  90                  95      


Thr Lys Ile Thr Phe Pro Arg Glu Gly Asp Glu Thr Pro Asn Ser Ile 
            100                 105                 110         


Pro Ala Asp Ile Val Phe Ile Ile Lys Asp Lys Asp His Pro Lys Phe 
        115                 120                 125             


Lys Arg Asp Gly Ser Asn Ile Ile Tyr Thr Ala Lys Ile Ser Leu Arg 
    130                 135                 140                 


Glu Ala Leu Cys Gly Cys Ser Ile Asn Val Pro Thr Leu Asp Gly Arg 
145                 150                 155                 160 


Asn Ile Pro Met Ser Val Asn Asp Ile Val Lys Pro Gly Met Arg Arg 
                165                 170                 175     


Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro Lys Asn Pro Asp Gln Arg 
            180                 185                 190         


Gly Asp Leu Leu Ile Glu Phe Glu Val Ser Phe Pro Asp Thr Ile Ser 
        195                 200                 205             


Ser Ser Ser Lys Glu Val Leu Arg Lys His Leu Pro Ala Ser 
    210                 215                 220         


<210>  6505
<211>  2637
<212>  DNA
<213>  Homosapiens

<400>  6505
gcgctggtgt gggttagggc tgagaaagaa cgacaggaac agagacgtcg cgaggattaa     60

gtttaagact tcgcgagaac agaatttctt ttggcacctc ctctccgcgc gttcttgggg    120

gttgaaagga ggagcaggag gtactgatgg acaaggaggt accttccggt acacctttca    180

tggcgatcct catgctacat ttgctgcatt tttcggaggg tccaacccct ttgaaatttt    240

ctttggaaga cgaatgggtg gtggtagaga ttctgaagaa atggaaatag atggtgatcc    300

ttttagtgcc tttggtttca gcatgaatgg atatccaaga gacaggaatt ctgtggggcc    360

atcccgcctc aaacaagatc ctccagttat tcatgaactt agagtatcac ttgaagagat    420

atatagtggt tgtaccaaac ggatgaagat ttctcgaaaa aggctaaacg ctgatggaag    480

gagttacaga tctgaggaca aaattcttac cattgagatt aaaaaagggt ggaaagaagg    540

caccaaaatt acttttccaa gagaaggaga tgaaacacca aatagtattc cagcagacat    600

tgtttttatc attaaagaca aagatcatcc aaaatttaaa agggatggat caaatataat    660

ttatactgct aaaattagtt tacgagaggc attgtgtggc tgctcaatta atgtaccaac    720

actggatgga agaaacatac ctatgtcagt aaatgatatt gtgaaacccg gaatgaggag    780

aagaattatt ggatatgggc tgccatttcc aaaaaatcct gaccaacgtg gtgaccttct    840

aatagaattt gaggtgtcct tcccagatac tatatcttct tcatccaaag aagtacttag    900

gaaacatctt cctgcctcat agaatgaaga actttgttac acatattttg ataaggcact    960

gaaaatataa aaggactggt agtttactga tgtagatgtg aattctgtat aaagatgtgt   1020

aaattctttt gagggttcat taaattgcat gaatagagac gggtcaaata aataggcaaa   1080

agggattttt acagttagag ataaaagaga aaaccattca ctgtatttta tttcatttct   1140

cctgattcag atatttttag taatttgctt atatgtaaaa gttgtttttg tggagtcagt   1200

ggatatattt ctaatgaagt gctagactat ccaattactt aatttcttat acctttagat   1260

aatcagtatg aaaagttccc atttataatg gaaatgaaaa ttcttaacta aactatacat   1320

gtaatatgta tttctagaag agaataaaaa cccaagtcag ttattagatt taaatcacct   1380

tctgaaatgc tgctataggg ctggtatctg taaaagaata tcctgatgca tctgtttcac   1440

cattttgatt tttaaagtat gctgtagcat ttcttaataa catcgttgtg atgttcttaa   1500

ggcagatctt tcttcataaa aaggaaagta atggcaattt ctctcctgtg gaaatcccaa   1560

ttgcttgaat tactgatatt ttagaataga ctttttaaaa tgccatatgt aattttatgc   1620

aagttgacta tatatcttgt acttaataaa ttataggctc attttgttct ctgctagttt   1680

aaagtaattc gtttaataat agatgtgttt ttagaggaaa tgctgttact tggaattaat   1740

tttccagtta tacagtcttc tataacttac taataatatt ctatatgtac tttatgtaat   1800

ttccctaaaa agaatgaact accactacac tatggtgtta aaccaaaata tagggaaaat   1860

aaacactaac tgctgcttat ggataatgtt gcaactactt gttatgcata taaatatttt   1920

actttttcac atgtatagat tgcatttctt aggtgtttta attttttaaa tatatttatg   1980

ttttaaaaat ttagttttgt tttctgtttt ataactatag tgagaatgat gttttgaagc   2040

aaaatttttg gttataaaat agttttcagg attatatata tatatactgg atcctatcgc   2100

cttttagtag aatatgaaat attcttttag aaatccaata taaataggtt ataatagcca   2160

tattctttat tactttattg agatataatt tacatgccat aaagtttacc cttaaaatat   2220

ataattcagt ggtttttagt gatatttaca aagtggtaca atcatcatca ctttctaatt   2280

ccagaatatt ttcatcaccc caaaaagaaa tcctaaatcc attagcagtt acttcccatt   2340

cttcccttcc tccagcccct gaaaacacta ccatctactt ttcatctgta tggatttgtc   2400

tgttctggac atttcacata aatagactca aacaatatat ggcttttttt ttttttggtc   2460

tggcctcttt catttagctt aatgttttca aggttcatct atgttgtatc acgtatcagt   2520

actttatttt ttgtgtggca cgtcatatgg atataccaca atttgtttat cttttcatta   2580

attatgggca tttggcttat ttctactttt ttggctatta taaataatgc tgctgtg      2637


<210>  6506
<211>  222
<212>  PRT
<213>  Homosapiens

<400>  6506

Met Gly Gly Gly Arg Asp Ser Glu Glu Met Glu Ile Asp Gly Asp Pro 
1               5                   10                  15      


Phe Ser Ala Phe Gly Phe Ser Met Asn Gly Tyr Pro Arg Asp Arg Asn 
            20                  25                  30          


Ser Val Gly Pro Ser Arg Leu Lys Gln Asp Pro Pro Val Ile His Glu 
        35                  40                  45              


Leu Arg Val Ser Leu Glu Glu Ile Tyr Ser Gly Cys Thr Lys Arg Met 
    50                  55                  60                  


Lys Ile Ser Arg Lys Arg Leu Asn Ala Asp Gly Arg Ser Tyr Arg Ser 
65                  70                  75                  80  


Glu Asp Lys Ile Leu Thr Ile Glu Ile Lys Lys Gly Trp Lys Glu Gly 
                85                  90                  95      


Thr Lys Ile Thr Phe Pro Arg Glu Gly Asp Glu Thr Pro Asn Ser Ile 
            100                 105                 110         


Pro Ala Asp Ile Val Phe Ile Ile Lys Asp Lys Asp His Pro Lys Phe 
        115                 120                 125             


Lys Arg Asp Gly Ser Asn Ile Ile Tyr Thr Ala Lys Ile Ser Leu Arg 
    130                 135                 140                 


Glu Ala Leu Cys Gly Cys Ser Ile Asn Val Pro Thr Leu Asp Gly Arg 
145                 150                 155                 160 


Asn Ile Pro Met Ser Val Asn Asp Ile Val Lys Pro Gly Met Arg Arg 
                165                 170                 175     


Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro Lys Asn Pro Asp Gln Arg 
            180                 185                 190         


Gly Asp Leu Leu Ile Glu Phe Glu Val Ser Phe Pro Asp Thr Ile Ser 
        195                 200                 205             


Ser Ser Ser Lys Glu Val Leu Arg Lys His Leu Pro Ala Ser 
    210                 215                 220         


<210>  6507
<211>  845
<212>  DNA
<213>  Homosapiens

<400>  6507
aagtttaaga cttcgcgaga acagaatttc ttttggcacc tcctctccgc gcgttcttgg     60

ggctggagtg cagtggcacg atcttggctc actgaaacct cagcctccca ggttcaagag    120

attctcccac ctcagcctct ggagtagctg ggatcacagt tttgctcctg ttgcccaggc    180

cggagtgcaa tggtgcagtc ttggctcact gtaacctctg cctcccaggt tcaagcgatt    240

ctcctgcctc agcctcccaa gtactcttca attagggttg aaaggaggag caggaggtac    300

tgatggacaa ggaggtacct tccggtacac ctttcatggc gatcctcatg ctacatttgc    360

tgcatttttc ggagggtcca acccctttga aattttcttt ggaagacgaa tgggtggtgg    420

tagagattct gaagaaatgg aaatagatgg tgatcctttt agtgcctttg gtttcagcat    480

gaatggatat ccaagagaca ggaattctgt ggggccatcc cgcctcaaac aagatcctcc    540

agttattcat gaacttagag tatcacttga agagatatat agtggttgta ccaaacggat    600

gaagatttct cgaaaaaggc taaacgctga tggaaggagt tacagatctg aggacaaaat    660

tcttaccatt gagattaaaa aagggtggaa agaaggcacc aaaattactt ttccaagaga    720

aggagatgaa acaccaaata gtattccagc agacattgtt tttatcatta aagacaaaga    780

tcatccaaaa tttaaaaggg atggatcaaa tataatttat actgctaaaa ttagtttacg    840

agagg                                                                845


<210>  6508
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  6508

Met Val Gln Ser Trp Leu Thr Val Thr Ser Ala Ser Gln Val Gln Ala 
1               5                   10                  15      


Ile Leu Leu Pro Gln Pro Pro Lys Tyr Ser Ser Ile Arg Val Glu Arg 
            20                  25                  30          


Arg Ser Arg Arg Tyr 
        35          


<210>  6509
<211>  2023
<212>  DNA
<213>  Homosapiens

<400>  6509
gttttggtat tatatactta acagacaaat agcttaaaat taaaaaatcc ctaaagtaga     60

attgtcgttc cttttatctg tatattaact ttaacttctt ttaacatagg gtgtttaatg    120

actgtgatga ttttcaccta gtatggagta cataaatata tagttgtgac attctgtgtt    180

gaaatattgg catgttaacc catttgtcct gtttaattag gaaataaaga cggtagagct    240

agtcggaaaa tgaatagtta atcgtggagg aggagaaaac atagctcagt actttgacta    300

gaggcagctg ggaaagtgac gtcctgtagc atttgctgtt ctagaaagta cagagacacg    360

tagtgaaaat gggaggatct agaaggaggc tgtctcctgt gtagtgtata tttatctgta    420

agtgagccgt tggggaagga ttgaatacag agacgctgtc tgcttgctgc cttaagacag    480

ctagctgaat tgctgattaa cttttaaaat acccagcttg gtttattttt cttagaatct    540

gttgctaaga ctggggacgc tgttttcttt tacaaaggga aatctaagtt aatttcaagg    600

cattcgaaat ggggaaagac tattattgca ttttgggaat tgagaaagga gcttcagatg    660

aagatattaa aaaggcttac cgaaaacaag ccctcaaatt tcatccggac aagaacaaat    720

ctcctcaggc agaggaaaaa tttaaagagg tcgcagaagc ttatgaagta ttgagtgatc    780

ctaaaaagag agaaatatat gatcagtttg gggaggaagg cattgtgtgg ctgctcaatt    840

aatgtaccaa cactggatgg aagaaacata cctatgtcag taaatgatat tgtgaaaccc    900

ggaatgagga gaagaattat tggatatggg ctgccatttc caaaaaatcc tgaccaacgt    960

ggtgaccttc taatagaatt tgaggtgtcc ttcccagata ctatatcttc ttcatccaaa   1020

gaagtactta ggaaacatct tcctgcctca tagaatgaag aactttgtta cacatatttt   1080

gataaggcac tgaaaatata aaaggactgg tagtttactg atgtagatgt gaattctgta   1140

taaagatgtg taaattcttt tgagggttca ttaaattgca tgaatagaga cgggtcaaat   1200

aaataggcaa aagggatttt tacagttaga gataaaagag aaaaccattc actgtatttt   1260

atttcatttc tcctgattca gatattttta gtaatttgct tatatgtaaa agttgttttt   1320

gtggagtcag tggatatatt tctaatgaag tgctagacta tccaattact taatttctta   1380

tacctttaga taatcagtat gaaaagttcc catttataat ggaaatgaaa attcttaact   1440

aaactataca tgtaatatgt atttctagaa gagaataaaa acccaagtca gttattagat   1500

ttaaatcacc ttctgaaatg ctgctatagg gctggtatct gtaaaagaat atcctgatgc   1560

atctgtttca ccattttgat ttttaaagta tgctgtagca tttcttaata acatcgttgt   1620

gatgttctta aggcagatct ttcttcataa aaaggaaagt aatggcaatt tctctcctgt   1680

ggaaatccca attgcttgaa ttactgatat tttagaatag actttttaaa atgccatatg   1740

taattttatg caagttgact atatatcttg tacttaataa attataggct cattttgttc   1800

tctgctagtt taaagtaatt cgtttaataa tagatgtgtt tttagaggaa atgctgttac   1860

ttggaattaa ttttccagtt atacagtctt ctataactta ctaataatat tctatatgta   1920

ctttatgtaa tttccctaaa aagaatgaac taccactaca ctatggtgtt aaaccaaaat   1980

atagggaaaa taaacactaa ctgctgctta tggataatgt tgc                     2023


<210>  6510
<211>  84
<212>  PRT
<213>  Homosapiens

<400>  6510

Met Ile Ser Leu Gly Arg Lys Ala Leu Cys Gly Cys Ser Ile Asn Val 
1               5                   10                  15      


Pro Thr Leu Asp Gly Arg Asn Ile Pro Met Ser Val Asn Asp Ile Val 
            20                  25                  30          


Lys Pro Gly Met Arg Arg Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro 
        35                  40                  45              


Lys Asn Pro Asp Gln Arg Gly Asp Leu Leu Ile Glu Phe Glu Val Ser 
    50                  55                  60                  


Phe Pro Asp Thr Ile Ser Ser Ser Ser Lys Glu Val Leu Arg Lys His 
65                  70                  75                  80  


Leu Pro Ala Ser 
                


<210>  6511
<211>  2592
<212>  DNA
<213>  Homosapiens

<400>  6511
gttttggtat tatatactta acagacaaat agcttaaaat taaaaaatcc ctaaagtaga     60

attgtcgttc cttttatctg tatattaact ttaacttctt ttaacatagg gtgtttaatg    120

actgtgatga ttttcaccta gtatggagta cataaatata tagttgtgac attctgtgtt    180

gaaatattgg catgttaacc catttgtcct gtttaattag gaaataaaga cggtagagct    240

agtcggaaaa tgaatagtta atcgtggagg aggagaaaac atagctcagt actttgacta    300

gaggcagctg ggaaagtgac gtcctgtagc atttgctgtt ctagaaagta cagagacacg    360

tagtgaaaat gggaggatct agaaggaggc tgtctcctgt gtagtgtata tttatctgta    420

agtgagccgt tggggaagga ttgaatacag agacgctgtc tgcttgctgc cttaagacag    480

ctagctgaat tgctgattaa cttttaaaat acccagcttg gtttattttt cttagaatct    540

gttgctaaga ctggggacgc tgttttcttt tacaaaggga aatctaagtt aatttcaagg    600

cattcgaaat ggggaaagac tattattgca ttttgggaat tgagaaagga gcttcagatg    660

aagatattaa aaaggcttac cgaaaacaag ccctcaaatt tcatccggac aagaacaaat    720

ctcctcaggc agaggaaaaa tttaaagagg tcgcagaagc ttatgaagta ttgagtgatc    780

ctaaaaagag agaaatatat gatcagtttg gggaggaagg gttgaaagga ggagcaggag    840

gtactgatgg acaaggaggt accttccggt acacctttca tggcgatcct catgctacat    900

ttgctgcatt tttcggaggg tccaacccct ttgaaatttt ctttggaaga cgaatgggtg    960

gtggtagaga ttctgaagaa atggaaatag atggtgatcc ttttagtgcc tttggtttca   1020

gcatgaatgg atatccaaga gacaggaatt ctgtggggcc atcccgcctc aaacaagatc   1080

ctccagttat tcatgaactt agagtatcac ttgaagagat atatagtggt tgtaccaaac   1140

ggatgaagat ttctcgaaaa aggctaaacg ctgatggaag gagttacaga tctgaggaca   1200

aaattcttac cattgagatt aaaaaagggt ggaaagaagg caccaaaatt acttttccaa   1260

gagaaggaga tgaaacacca aatagtattc cagcagacat tgtttttatc attaaagaca   1320

aagatcatcc aaaatttaaa agggatggat caaatataat ttatactgct aaaattagtt   1380

tacgagaggc attgtgtggc tgctcaatta atgtaccaac actggatgga agaaacatac   1440

ctatgtcagt aaatgatatt gtgaaacccg gaatgaggag aagaattatt ggatatgggc   1500

tgccatttcc aaaaaatcct gaccaacgtg gtgaccttct aatagaattt gaggtgtcct   1560

tcccagatac tatatcttct tcatccaaag aagtacttag gaaacatctt cctgcctcat   1620

agaatgaaga actttgttac acatattttg ataaggcact gaaaatataa aaggactggt   1680

agtttactga tgtagatgtg aattctgtat aaagatgtgt aaattctttt gagggttcat   1740

taaattgcat gaatagagac gggtcaaata aataggcaaa agggattttt acagttagag   1800

ataaaagaga aaaccattca ctgtatttta tttcatttct cctgattcag atatttttag   1860

taatttgctt atatgtaaaa gttgtttttg tggagtcagt ggatatattt ctaatgaagt   1920

gctagactat ccaattactt aatttcttat acctttagat aatcagtatg aaaagttccc   1980

atttataatg gaaatgaaaa ttcttaacta aactatacat gtaatatgta tttctagaag   2040

agaataaaaa cccaagtcag ttattagatt taaatcacct tctgaaatgc tgctataggg   2100

ctggtatctg taaaagaata tcctgatgca tctgtttcac cattttgatt tttaaagtat   2160

gctgtagcat ttcttaataa catcgttgtg atgttcttaa ggcagatctt tcttcataaa   2220

aaggaaagta atggcaattt ctctcctgtg gaaatcccaa ttgcttgaat tactgatatt   2280

ttagaataga ctttttaaaa tgccatatgt aattttatgc aagttgacta tatatcttgt   2340

acttaataaa ttataggctc attttgttct ctgctagttt aaagtaattc gtttaataat   2400

agatgtgttt ttagaggaaa tgctgttact tggaattaat tttccagtta tacagtcttc   2460

tataacttac taataatatt ctatatgtac tttatgtaat ttccctaaaa agaatgaact   2520

accactacac tatggtgtta aaccaaaata tagggaaaat aaacactaac tgctgcttat   2580

ggataatgtt gc                                                       2592


<210>  6512
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  6512

Met Gly Lys Asp Tyr Tyr Cys Ile Leu Gly Ile Glu Lys Gly Ala Ser 
1               5                   10                  15      


Asp Glu Asp Ile Lys Lys Ala Tyr Arg Lys Gln Ala Leu Lys Phe His 
            20                  25                  30          


Pro Asp Lys Asn Lys Ser Pro Gln Ala Glu Glu Lys Phe Lys Glu Val 
        35                  40                  45              


Ala Glu Ala Tyr Glu Val Leu Ser Asp Pro Lys Lys Arg Glu Ile Tyr 
    50                  55                  60                  


Asp Gln Phe Gly Glu Glu Gly Leu Lys Gly Gly Ala Gly Gly Thr Asp 
65                  70                  75                  80  


Gly Gln Gly Gly Thr Phe Arg Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ala Phe Phe Gly Gly Ser Asn Pro Phe Glu Ile Phe Phe 
            100                 105                 110         


Gly Arg Arg Met Gly Gly Gly Arg Asp Ser Glu Glu Met Glu Ile Asp 
        115                 120                 125             


Gly Asp Pro Phe Ser Ala Phe Gly Phe Ser Met Asn Gly Tyr Pro Arg 
    130                 135                 140                 


Asp Arg Asn Ser Val Gly Pro Ser Arg Leu Lys Gln Asp Pro Pro Val 
145                 150                 155                 160 


Ile His Glu Leu Arg Val Ser Leu Glu Glu Ile Tyr Ser Gly Cys Thr 
                165                 170                 175     


Lys Arg Met Lys Ile Ser Arg Lys Arg Leu Asn Ala Asp Gly Arg Ser 
            180                 185                 190         


Tyr Arg Ser Glu Asp Lys Ile Leu Thr Ile Glu Ile Lys Lys Gly Trp 
        195                 200                 205             


Lys Glu Gly Thr Lys Ile Thr Phe Pro Arg Glu Gly Asp Glu Thr Pro 
    210                 215                 220                 


Asn Ser Ile Pro Ala Asp Ile Val Phe Ile Ile Lys Asp Lys Asp His 
225                 230                 235                 240 


Pro Lys Phe Lys Arg Asp Gly Ser Asn Ile Ile Tyr Thr Ala Lys Ile 
                245                 250                 255     


Ser Leu Arg Glu Ala Leu Cys Gly Cys Ser Ile Asn Val Pro Thr Leu 
            260                 265                 270         


Asp Gly Arg Asn Ile Pro Met Ser Val Asn Asp Ile Val Lys Pro Gly 
        275                 280                 285             


Met Arg Arg Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro Lys Asn Pro 
    290                 295                 300                 


Asp Gln Arg Gly Asp Leu Leu Ile Glu Phe Glu Val Ser Phe Pro Asp 
305                 310                 315                 320 


Thr Ile Ser Ser Ser Ser Lys Glu Val Leu Arg Lys His Leu Pro Ala 
                325                 330                 335     


Ser 
    


<210>  6513
<211>  2123
<212>  DNA
<213>  Homosapiens

<400>  6513
gttttggtat tatatactta acagacaaat agcttaaaat taaaaaatcc ctaaagtaga     60

attgtcgttc cttttatctg tatattaact ttaacttctt ttaacatagg gtgtttaatg    120

actgtgatga ttttcaccta gtatggagta cataaatata tagttgtgac attctgtgtt    180

gaaatattgg catgttaacc catttgtcct gtttaattag gaaataaaga cggtagagct    240

agtcggaaaa tgaatagtta atcgtggagg aggagaaaac atagctcagt actttgacta    300

gaggcagctg ggaaagtgac gtcctgtagc atttgctgtt ctagaaagta cagagacacg    360

tagtgaaaat gggaggatct agaaggaggc tgtctcctgt gtagtgtata tttatctgta    420

agtgagccgt tggggaagga ttgaatacag agacgctgtc tgcttgctgc cttaagacag    480

ctagctgaat tgctgattaa cttttaaaat acccagcttg gtttattttt cttagaatct    540

gttgctaaga ctggggacgc tgttttcttt tacaaaggga aatctaagtt aatttcaagg    600

cattcgaaat ggggaaagac tattattgca ttttgggaat tgagaaagga gcttcagatg    660

aagatattaa aaaggcttac cgaaaacaag ccctcaaatt tcatccggac aagaacaaat    720

ctcctcaggc agaggaaaaa tttaaagagg tcgcagaagc ttatgaagta ttgagtgatc    780

ctaaaaagag agaaatatat gatcagtttg gggaggaagg cattgtgtgg ctgctcaatt    840

aatgtaccaa cactggatgg aagaaacata cctatgtcag taaatgatat tgtgaaaccc    900

ggaatgagga gaagaattat tggatatggg ctgccatttc caaaaaatcc tgaccaacgt    960

ggtgaccttc taatagaatt tgaggtgtcc ttcccagata ctatatcttc ttcatccaaa   1020

gaagtactta ggaaacatct tcctgcctca tagaatgaag aactttgtta cacatatttt   1080

gataaggcac tgaaaatata aaaggactgg tagtttactg atgtagatgt gaattctgta   1140

taaagatgtg taaattcttt tgagggttca ttaaattgca tgaatagaga cgggtcaaat   1200

aaataggcaa aagggatttt tacagttaga gataaaagag aaaaccattc actgtatttt   1260

atttcatttc tcctgattca gatattttta gtaatttgct tatatgtaaa agttgttttt   1320

gtggagtcag tggatatatt tctaatgaag tgctagacta tccaattact taatttctta   1380

tacctttaga taatcagtat gaaaagttcc catttataat ggaaatgaaa attcttaact   1440

aaactataca tgtaatatgt atttctagaa gagaataaaa acccaagtca gttattagat   1500

ttaaatcacc ttctgaaatg ctgctatagg gctggtatct gtaaaagaat atcctgatgc   1560

atctgtttca ccattttgat ttttaaagta tgctgtagca tttcttaata acatcgttgt   1620

gatgttctta aggcagatct ttcttcataa aaaggaaagt aatggcaatt tctctcctgt   1680

ggaaatccca attgcttgaa ttactgatat tttagaatag actttttaaa atgccatatg   1740

taattttatg caagttgact atatatcttg tacttaataa attataggct cattttgttc   1800

tctgctagtt taaagtaatt cgtttaataa tagatgtgtt tttagaggaa atgctgttac   1860

ttggaattaa ttttccagtt atacagtctt ctataactta ctaataatat tctatatgta   1920

ctttatgtaa tttccctaaa aagaatgaac taccactaca ctatggtgtt aaaccaaaat   1980

atagggaaaa taaacactaa ctgctgctta tggataatgt tgcaactact tgttatgcat   2040

ataaatattt tactttttca catgtataga ttgcatttct taggtgtttt aattttttaa   2100

atatatttat gttttaaaaa ttt                                           2123


<210>  6514
<211>  84
<212>  PRT
<213>  Homosapiens

<400>  6514

Met Ile Ser Leu Gly Arg Lys Ala Leu Cys Gly Cys Ser Ile Asn Val 
1               5                   10                  15      


Pro Thr Leu Asp Gly Arg Asn Ile Pro Met Ser Val Asn Asp Ile Val 
            20                  25                  30          


Lys Pro Gly Met Arg Arg Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro 
        35                  40                  45              


Lys Asn Pro Asp Gln Arg Gly Asp Leu Leu Ile Glu Phe Glu Val Ser 
    50                  55                  60                  


Phe Pro Asp Thr Ile Ser Ser Ser Ser Lys Glu Val Leu Arg Lys His 
65                  70                  75                  80  


Leu Pro Ala Ser 
                


<210>  6515
<211>  2692
<212>  DNA
<213>  Homosapiens

<400>  6515
gttttggtat tatatactta acagacaaat agcttaaaat taaaaaatcc ctaaagtaga     60

attgtcgttc cttttatctg tatattaact ttaacttctt ttaacatagg gtgtttaatg    120

actgtgatga ttttcaccta gtatggagta cataaatata tagttgtgac attctgtgtt    180

gaaatattgg catgttaacc catttgtcct gtttaattag gaaataaaga cggtagagct    240

agtcggaaaa tgaatagtta atcgtggagg aggagaaaac atagctcagt actttgacta    300

gaggcagctg ggaaagtgac gtcctgtagc atttgctgtt ctagaaagta cagagacacg    360

tagtgaaaat gggaggatct agaaggaggc tgtctcctgt gtagtgtata tttatctgta    420

agtgagccgt tggggaagga ttgaatacag agacgctgtc tgcttgctgc cttaagacag    480

ctagctgaat tgctgattaa cttttaaaat acccagcttg gtttattttt cttagaatct    540

gttgctaaga ctggggacgc tgttttcttt tacaaaggga aatctaagtt aatttcaagg    600

cattcgaaat ggggaaagac tattattgca ttttgggaat tgagaaagga gcttcagatg    660

aagatattaa aaaggcttac cgaaaacaag ccctcaaatt tcatccggac aagaacaaat    720

ctcctcaggc agaggaaaaa tttaaagagg tcgcagaagc ttatgaagta ttgagtgatc    780

ctaaaaagag agaaatatat gatcagtttg gggaggaagg gttgaaagga ggagcaggag    840

gtactgatgg acaaggaggt accttccggt acacctttca tggcgatcct catgctacat    900

ttgctgcatt tttcggaggg tccaacccct ttgaaatttt ctttggaaga cgaatgggtg    960

gtggtagaga ttctgaagaa atggaaatag atggtgatcc ttttagtgcc tttggtttca   1020

gcatgaatgg atatccaaga gacaggaatt ctgtggggcc atcccgcctc aaacaagatc   1080

ctccagttat tcatgaactt agagtatcac ttgaagagat atatagtggt tgtaccaaac   1140

ggatgaagat ttctcgaaaa aggctaaacg ctgatggaag gagttacaga tctgaggaca   1200

aaattcttac cattgagatt aaaaaagggt ggaaagaagg caccaaaatt acttttccaa   1260

gagaaggaga tgaaacacca aatagtattc cagcagacat tgtttttatc attaaagaca   1320

aagatcatcc aaaatttaaa agggatggat caaatataat ttatactgct aaaattagtt   1380

tacgagaggc attgtgtggc tgctcaatta atgtaccaac actggatgga agaaacatac   1440

ctatgtcagt aaatgatatt gtgaaacccg gaatgaggag aagaattatt ggatatgggc   1500

tgccatttcc aaaaaatcct gaccaacgtg gtgaccttct aatagaattt gaggtgtcct   1560

tcccagatac tatatcttct tcatccaaag aagtacttag gaaacatctt cctgcctcat   1620

agaatgaaga actttgttac acatattttg ataaggcact gaaaatataa aaggactggt   1680

agtttactga tgtagatgtg aattctgtat aaagatgtgt aaattctttt gagggttcat   1740

taaattgcat gaatagagac gggtcaaata aataggcaaa agggattttt acagttagag   1800

ataaaagaga aaaccattca ctgtatttta tttcatttct cctgattcag atatttttag   1860

taatttgctt atatgtaaaa gttgtttttg tggagtcagt ggatatattt ctaatgaagt   1920

gctagactat ccaattactt aatttcttat acctttagat aatcagtatg aaaagttccc   1980

atttataatg gaaatgaaaa ttcttaacta aactatacat gtaatatgta tttctagaag   2040

agaataaaaa cccaagtcag ttattagatt taaatcacct tctgaaatgc tgctataggg   2100

ctggtatctg taaaagaata tcctgatgca tctgtttcac cattttgatt tttaaagtat   2160

gctgtagcat ttcttaataa catcgttgtg atgttcttaa ggcagatctt tcttcataaa   2220

aaggaaagta atggcaattt ctctcctgtg gaaatcccaa ttgcttgaat tactgatatt   2280

ttagaataga ctttttaaaa tgccatatgt aattttatgc aagttgacta tatatcttgt   2340

acttaataaa ttataggctc attttgttct ctgctagttt aaagtaattc gtttaataat   2400

agatgtgttt ttagaggaaa tgctgttact tggaattaat tttccagtta tacagtcttc   2460

tataacttac taataatatt ctatatgtac tttatgtaat ttccctaaaa agaatgaact   2520

accactacac tatggtgtta aaccaaaata tagggaaaat aaacactaac tgctgcttat   2580

ggataatgtt gcaactactt gttatgcata taaatatttt actttttcac atgtatagat   2640

tgcatttctt aggtgtttta attttttaaa tatatttatg ttttaaaaat tt           2692


<210>  6516
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  6516

Met Gly Lys Asp Tyr Tyr Cys Ile Leu Gly Ile Glu Lys Gly Ala Ser 
1               5                   10                  15      


Asp Glu Asp Ile Lys Lys Ala Tyr Arg Lys Gln Ala Leu Lys Phe His 
            20                  25                  30          


Pro Asp Lys Asn Lys Ser Pro Gln Ala Glu Glu Lys Phe Lys Glu Val 
        35                  40                  45              


Ala Glu Ala Tyr Glu Val Leu Ser Asp Pro Lys Lys Arg Glu Ile Tyr 
    50                  55                  60                  


Asp Gln Phe Gly Glu Glu Gly Leu Lys Gly Gly Ala Gly Gly Thr Asp 
65                  70                  75                  80  


Gly Gln Gly Gly Thr Phe Arg Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ala Phe Phe Gly Gly Ser Asn Pro Phe Glu Ile Phe Phe 
            100                 105                 110         


Gly Arg Arg Met Gly Gly Gly Arg Asp Ser Glu Glu Met Glu Ile Asp 
        115                 120                 125             


Gly Asp Pro Phe Ser Ala Phe Gly Phe Ser Met Asn Gly Tyr Pro Arg 
    130                 135                 140                 


Asp Arg Asn Ser Val Gly Pro Ser Arg Leu Lys Gln Asp Pro Pro Val 
145                 150                 155                 160 


Ile His Glu Leu Arg Val Ser Leu Glu Glu Ile Tyr Ser Gly Cys Thr 
                165                 170                 175     


Lys Arg Met Lys Ile Ser Arg Lys Arg Leu Asn Ala Asp Gly Arg Ser 
            180                 185                 190         


Tyr Arg Ser Glu Asp Lys Ile Leu Thr Ile Glu Ile Lys Lys Gly Trp 
        195                 200                 205             


Lys Glu Gly Thr Lys Ile Thr Phe Pro Arg Glu Gly Asp Glu Thr Pro 
    210                 215                 220                 


Asn Ser Ile Pro Ala Asp Ile Val Phe Ile Ile Lys Asp Lys Asp His 
225                 230                 235                 240 


Pro Lys Phe Lys Arg Asp Gly Ser Asn Ile Ile Tyr Thr Ala Lys Ile 
                245                 250                 255     


Ser Leu Arg Glu Ala Leu Cys Gly Cys Ser Ile Asn Val Pro Thr Leu 
            260                 265                 270         


Asp Gly Arg Asn Ile Pro Met Ser Val Asn Asp Ile Val Lys Pro Gly 
        275                 280                 285             


Met Arg Arg Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro Lys Asn Pro 
    290                 295                 300                 


Asp Gln Arg Gly Asp Leu Leu Ile Glu Phe Glu Val Ser Phe Pro Asp 
305                 310                 315                 320 


Thr Ile Ser Ser Ser Ser Lys Glu Val Leu Arg Lys His Leu Pro Ala 
                325                 330                 335     


Ser 
    


<210>  6517
<211>  3337
<212>  DNA
<213>  Homosapiens

<400>  6517
gttttggtat tatatactta acagacaaat agcttaaaat taaaaaatcc ctaaagtaga     60

attgtcgttc cttttatctg tatattaact ttaacttctt ttaacatagg gtgtttaatg    120

actgtgatga ttttcaccta gtatggagta cataaatata tagttgtgac attctgtgtt    180

gaaatattgg catgttaacc catttgtcct gtttaattag gaaataaaga cggtagagct    240

agtcggaaaa tgaatagtta atcgtggagg aggagaaaac atagctcagt actttgacta    300

gaggcagctg ggaaagtgac gtcctgtagc atttgctgtt ctagaaagta cagagacacg    360

tagtgaaaat gggaggatct agaaggaggc tgtctcctgt gtagtgtata tttatctgta    420

agtgagccgt tggggaagga ttgaatacag agacgctgtc tgcttgctgc cttaagacag    480

ctagctgaat tgctgattaa cttttaaaat acccagcttg gtttattttt cttagaatct    540

gttgctaaga ctggggacgc tgttttcttt tacaaaggga aatctaagtt aatttcaagg    600

cattcgaaat ggggaaagac tattattgca ttttgggaat tgagaaagga gcttcagatg    660

aagatattaa aaaggcttac cgaaaacaag ccctcaaatt tcatccggac aagaacaaat    720

ctcctcaggc agaggaaaaa tttaaagagg tcgcagaagc ttatgaagta ttgagtgatc    780

ctaaaaagag agaaatatat gatcagtttg gggaggaagg gttgaaagga ggagcaggag    840

gtactgatgg acaaggaggt accttccggt acacctttca tggcgatcct catgctacat    900

ttgctgcatt tttcggaggg tccaacccct ttgaaatttt ctttggaaga cgaatgggtg    960

gtggtagaga ttctgaagaa atggaaatag atggtgatcc ttttagtgcc tttggtttca   1020

gcatgaatgg atatccaaga gacaggaatt ctgtggggcc atcccgcctc aaacaagatc   1080

ctccagttat tcatgaactt agagtatcac ttgaagagat atatagtggt tgtaccaaac   1140

ggatgaagat ttctcgaaaa aggctaaacg ctgatggaag gagttacaga tctgaggaca   1200

aaattcttac cattgagatt aaaaaagggt ggaaagaagg caccaaaatt acttttccaa   1260

gagaaggaga tgaaacacca aatagtattc cagcagacat tgtttttatc attaaagaca   1320

aagatcatcc aaaatttaaa agggatggat caaatataat ttatactgct aaaattagtt   1380

tacgagaggc attgtgtggc tgctcaatta atgtaccaac actggatgga agaaacatac   1440

ctatgtcagt aaatgatatt gtgaaacccg gaatgaggag aagaattatt ggatatgggc   1500

tgccatttcc aaaaaatcct gaccaacgtg gtgaccttct aatagaattt gaggtgtcct   1560

tcccagatac tatatcttct tcatccaaag aagtacttag gaaacatctt cctgcctcat   1620

agaatgaaga actttgttac acatattttg ataaggcact gaaaatataa aaggactggt   1680

agtttactga tgtagatgtg aattctgtat aaagatgtgt aaattctttt gagggttcat   1740

taaattgcat gaatagagac gggtcaaata aataggcaaa agggattttt acagttagag   1800

ataaaagaga aaaccattca ctgtatttta tttcatttct cctgattcag atatttttag   1860

taatttgctt atatgtaaaa gttgtttttg tggagtcagt ggatatattt ctaatgaagt   1920

gctagactat ccaattactt aatttcttat acctttagat aatcagtatg aaaagttccc   1980

atttataatg gaaatgaaaa ttcttaacta aactatacat gtaatatgta tttctagaag   2040

agaataaaaa cccaagtcag ttattagatt taaatcacct tctgaaatgc tgctataggg   2100

ctggtatctg taaaagaata tcctgatgca tctgtttcac cattttgatt tttaaagtat   2160

gctgtagcat ttcttaataa catcgttgtg atgttcttaa ggcagatctt tcttcataaa   2220

aaggaaagta atggcaattt ctctcctgtg gaaatcccaa ttgcttgaat tactgatatt   2280

ttagaataga ctttttaaaa tgccatatgt aattttatgc aagttgacta tatatcttgt   2340

acttaataaa ttataggctc attttgttct ctgctagttt aaagtaattc gtttaataat   2400

agatgtgttt ttagaggaaa tgctgttact tggaattaat tttccagtta tacagtcttc   2460

tataacttac taataatatt ctatatgtac tttatgtaat ttccctaaaa agaatgaact   2520

accactacac tatggtgtta aaccaaaata tagggaaaat aaacactaac tgctgcttat   2580

ggataatgtt gcaactactt gttatgcata taaatatttt actttttcac atgtatagat   2640

tgcatttctt aggtgtttta attttttaaa tatatttatg ttttaaaaat ttagttttgt   2700

tttctgtttt ataactatag tgagaatgat gttttgaagc aaaatttttg gttataaaat   2760

agttttcagg attatatata tatatactgg atcctatcgc cttttagtag aatatgaaat   2820

attcttttag aaatccaata taaataggtt ataatagcca tattctttat tactttattg   2880

agatataatt tacatgccat aaagtttacc cttaaaatat ataattcagt ggtttttagt   2940

gatatttaca aagtggtaca atcatcatca ctttctaatt ccagaatatt ttcatcaccc   3000

caaaaagaaa tcctaaatcc attagcagtt acttcccatt cttcccttcc tccagcccct   3060

gaaaacacta ccatctactt ttcatctgta tggatttgtc tgttctggac atttcacata   3120

aatagactca aacaatatat ggcttttttt ttttttggtc tggcctcttt catttagctt   3180

aatgttttca aggttcatct atgttgtatc acgtatcagt actttatttt ttgtgtggca   3240

cgtcatatgg atataccaca atttgtttat cttttcatta attatgggca tttggcttat   3300

ttctactttt ttggctatta taaataatgc tgctgtg                            3337


<210>  6518
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  6518

Met Gly Lys Asp Tyr Tyr Cys Ile Leu Gly Ile Glu Lys Gly Ala Ser 
1               5                   10                  15      


Asp Glu Asp Ile Lys Lys Ala Tyr Arg Lys Gln Ala Leu Lys Phe His 
            20                  25                  30          


Pro Asp Lys Asn Lys Ser Pro Gln Ala Glu Glu Lys Phe Lys Glu Val 
        35                  40                  45              


Ala Glu Ala Tyr Glu Val Leu Ser Asp Pro Lys Lys Arg Glu Ile Tyr 
    50                  55                  60                  


Asp Gln Phe Gly Glu Glu Gly Leu Lys Gly Gly Ala Gly Gly Thr Asp 
65                  70                  75                  80  


Gly Gln Gly Gly Thr Phe Arg Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ala Phe Phe Gly Gly Ser Asn Pro Phe Glu Ile Phe Phe 
            100                 105                 110         


Gly Arg Arg Met Gly Gly Gly Arg Asp Ser Glu Glu Met Glu Ile Asp 
        115                 120                 125             


Gly Asp Pro Phe Ser Ala Phe Gly Phe Ser Met Asn Gly Tyr Pro Arg 
    130                 135                 140                 


Asp Arg Asn Ser Val Gly Pro Ser Arg Leu Lys Gln Asp Pro Pro Val 
145                 150                 155                 160 


Ile His Glu Leu Arg Val Ser Leu Glu Glu Ile Tyr Ser Gly Cys Thr 
                165                 170                 175     


Lys Arg Met Lys Ile Ser Arg Lys Arg Leu Asn Ala Asp Gly Arg Ser 
            180                 185                 190         


Tyr Arg Ser Glu Asp Lys Ile Leu Thr Ile Glu Ile Lys Lys Gly Trp 
        195                 200                 205             


Lys Glu Gly Thr Lys Ile Thr Phe Pro Arg Glu Gly Asp Glu Thr Pro 
    210                 215                 220                 


Asn Ser Ile Pro Ala Asp Ile Val Phe Ile Ile Lys Asp Lys Asp His 
225                 230                 235                 240 


Pro Lys Phe Lys Arg Asp Gly Ser Asn Ile Ile Tyr Thr Ala Lys Ile 
                245                 250                 255     


Ser Leu Arg Glu Ala Leu Cys Gly Cys Ser Ile Asn Val Pro Thr Leu 
            260                 265                 270         


Asp Gly Arg Asn Ile Pro Met Ser Val Asn Asp Ile Val Lys Pro Gly 
        275                 280                 285             


Met Arg Arg Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro Lys Asn Pro 
    290                 295                 300                 


Asp Gln Arg Gly Asp Leu Leu Ile Glu Phe Glu Val Ser Phe Pro Asp 
305                 310                 315                 320 


Thr Ile Ser Ser Ser Ser Lys Glu Val Leu Arg Lys His Leu Pro Ala 
                325                 330                 335     


Ser 
    


<210>  6519
<211>  2768
<212>  DNA
<213>  Homosapiens

<400>  6519
gttttggtat tatatactta acagacaaat agcttaaaat taaaaaatcc ctaaagtaga     60

attgtcgttc cttttatctg tatattaact ttaacttctt ttaacatagg gtgtttaatg    120

actgtgatga ttttcaccta gtatggagta cataaatata tagttgtgac attctgtgtt    180

gaaatattgg catgttaacc catttgtcct gtttaattag gaaataaaga cggtagagct    240

agtcggaaaa tgaatagtta atcgtggagg aggagaaaac atagctcagt actttgacta    300

gaggcagctg ggaaagtgac gtcctgtagc atttgctgtt ctagaaagta cagagacacg    360

tagtgaaaat gggaggatct agaaggaggc tgtctcctgt gtagtgtata tttatctgta    420

agtgagccgt tggggaagga ttgaatacag agacgctgtc tgcttgctgc cttaagacag    480

ctagctgaat tgctgattaa cttttaaaat acccagcttg gtttattttt cttagaatct    540

gttgctaaga ctggggacgc tgttttcttt tacaaaggga aatctaagtt aatttcaagg    600

cattcgaaat ggggaaagac tattattgca ttttgggaat tgagaaagga gcttcagatg    660

aagatattaa aaaggcttac cgaaaacaag ccctcaaatt tcatccggac aagaacaaat    720

ctcctcaggc agaggaaaaa tttaaagagg tcgcagaagc ttatgaagta ttgagtgatc    780

ctaaaaagag agaaatatat gatcagtttg gggaggaagg cattgtgtgg ctgctcaatt    840

aatgtaccaa cactggatgg aagaaacata cctatgtcag taaatgatat tgtgaaaccc    900

ggaatgagga gaagaattat tggatatggg ctgccatttc caaaaaatcc tgaccaacgt    960

ggtgaccttc taatagaatt tgaggtgtcc ttcccagata ctatatcttc ttcatccaaa   1020

gaagtactta ggaaacatct tcctgcctca tagaatgaag aactttgtta cacatatttt   1080

gataaggcac tgaaaatata aaaggactgg tagtttactg atgtagatgt gaattctgta   1140

taaagatgtg taaattcttt tgagggttca ttaaattgca tgaatagaga cgggtcaaat   1200

aaataggcaa aagggatttt tacagttaga gataaaagag aaaaccattc actgtatttt   1260

atttcatttc tcctgattca gatattttta gtaatttgct tatatgtaaa agttgttttt   1320

gtggagtcag tggatatatt tctaatgaag tgctagacta tccaattact taatttctta   1380

tacctttaga taatcagtat gaaaagttcc catttataat ggaaatgaaa attcttaact   1440

aaactataca tgtaatatgt atttctagaa gagaataaaa acccaagtca gttattagat   1500

ttaaatcacc ttctgaaatg ctgctatagg gctggtatct gtaaaagaat atcctgatgc   1560

atctgtttca ccattttgat ttttaaagta tgctgtagca tttcttaata acatcgttgt   1620

gatgttctta aggcagatct ttcttcataa aaaggaaagt aatggcaatt tctctcctgt   1680

ggaaatccca attgcttgaa ttactgatat tttagaatag actttttaaa atgccatatg   1740

taattttatg caagttgact atatatcttg tacttaataa attataggct cattttgttc   1800

tctgctagtt taaagtaatt cgtttaataa tagatgtgtt tttagaggaa atgctgttac   1860

ttggaattaa ttttccagtt atacagtctt ctataactta ctaataatat tctatatgta   1920

ctttatgtaa tttccctaaa aagaatgaac taccactaca ctatggtgtt aaaccaaaat   1980

atagggaaaa taaacactaa ctgctgctta tggataatgt tgcaactact tgttatgcat   2040

ataaatattt tactttttca catgtataga ttgcatttct taggtgtttt aattttttaa   2100

atatatttat gttttaaaaa tttagttttg ttttctgttt tataactata gtgagaatga   2160

tgttttgaag caaaattttt ggttataaaa tagttttcag gattatatat atatatactg   2220

gatcctatcg ccttttagta gaatatgaaa tattctttta gaaatccaat ataaataggt   2280

tataatagcc atattcttta ttactttatt gagatataat ttacatgcca taaagtttac   2340

ccttaaaata tataattcag tggtttttag tgatatttac aaagtggtac aatcatcatc   2400

actttctaat tccagaatat tttcatcacc ccaaaaagaa atcctaaatc cattagcagt   2460

tacttcccat tcttcccttc ctccagcccc tgaaaacact accatctact tttcatctgt   2520

atggatttgt ctgttctgga catttcacat aaatagactc aaacaatata tggctttttt   2580

tttttttggt ctggcctctt tcatttagct taatgttttc aaggttcatc tatgttgtat   2640

cacgtatcag tactttattt tttgtgtggc acgtcatatg gatataccac aatttgttta   2700

tcttttcatt aattatgggc atttggctta tttctacttt tttggctatt ataaataatg   2760

ctgctgtg                                                            2768


<210>  6520
<211>  84
<212>  PRT
<213>  Homosapiens

<400>  6520

Met Ile Ser Leu Gly Arg Lys Ala Leu Cys Gly Cys Ser Ile Asn Val 
1               5                   10                  15      


Pro Thr Leu Asp Gly Arg Asn Ile Pro Met Ser Val Asn Asp Ile Val 
            20                  25                  30          


Lys Pro Gly Met Arg Arg Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro 
        35                  40                  45              


Lys Asn Pro Asp Gln Arg Gly Asp Leu Leu Ile Glu Phe Glu Val Ser 
    50                  55                  60                  


Phe Pro Asp Thr Ile Ser Ser Ser Ser Lys Glu Val Leu Arg Lys His 
65                  70                  75                  80  


Leu Pro Ala Ser 
                


<210>  6521
<211>  453
<212>  DNA
<213>  Homosapiens

<400>  6521
gaaaaatgca gcaaatgtag catgaggatc gccatgaaag gtgtaccgga aggtacctcc     60

ttgtccatca gtacctcctg gatcactcaa tacttcataa gcttctgcga cctctttaaa    120

tttttcctct gcctgaggag atttgttctt gtccggatga aatttgaggg cttgttttcg    180

gtaagccttt ttaatatctt catctgaagc tcctttctca attcccaaaa tgcaataata    240

gtctttcccc atttcgaatg ccttgaaatt aacttagatt tccctttgta aaagaaaaca    300

gcgtccccag tcttagcaac agattctaag aaaaataaac caagctgggt attttaaaag    360

ttaatcagca attcagctag ctgtcttaag gcagcaagca gacagcgtct ctgtattcaa    420

tccttcccca acggctcact tacagataaa tat                                 453


<210>  6522
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  6522

Met Arg Ile Ala Met Lys Gly Val Pro Glu Gly Thr Ser Leu Ser Ile 
1               5                   10                  15      


Ser Thr Ser Trp Ile Thr Gln Tyr Phe Ile Ser Phe Cys Asp Leu Phe 
            20                  25                  30          


Lys Phe Phe Leu Cys Leu Arg Arg Phe Val Leu Val Arg Met Lys Phe 
        35                  40                  45              


Glu Gly Leu Phe Ser Val Ser Leu Phe Asn Ile Phe Ile 
    50                  55                  60      


<210>  6523
<211>  2822
<212>  DNA
<213>  Homosapiens

<400>  6523
gggcgggcgg gcggctgctc cggtccaggg gtggaggtcg gggccctgac ccgacgcagc     60

caggcggaag cgcggctgcc attggaggct gcttttacct gcgcggggcc cggggcgcaa    120

agtccgaggc gccgggggga ggaggcggcg gacggcagcg caggtgggcc cgcgctctcg    180

gccctgcaag atgcccctga agctgcgggg gaagaagaag gccaagtcca aggagaccgc    240

cgggctggtg gagggcgagc cgacgggcgc gggcggcggg agcctctcag cgtcccgggc    300

tcccgcacgc aggctggtct tccacgcgca gctggcgcac ggtagtgcca cgggccgagt    360

ggagggcttc tccagcatcc aggagctcta cgcccagatc gcgggcgcgt ttgaaatctc    420

gccgtcggag atcttatatt gcactttaaa cacacctaaa attgacatgg aaagactctt    480

aggaggacaa ctaggactag aagatttcat atttgcccat gtgaaaggaa tcgaaaaaga    540

agtgaatgtg tataaatctg aggattcact tggtctcacc attacagata atggtgttgg    600

ctatgctttt ataaagagaa ttaaagatgg tggtgttatt gactcagtta aaacaatctg    660

tgttggggat catattgaat ccataaatgg agaaaatatt gttgggtggc gtcactatga    720

tgttgctaag aagttaaagg aattaaaaaa ggaggaactc tttactatga agttaataga    780

acctaagaag gcatttgaaa tagagctgag gtcaaaggct ggaaagtcat caggagaaaa    840

aattggttgt ggaagggcaa cacttcgcct gagatcaaaa ggtcctgcca ccgtggaaga    900

aatgccttct gaaaccaaag caaaggcaat tgaaaagatt gatgatgttc ttgagttgta    960

catgggaatt cgagatattg atttagccac cacaatgttt gaagctggaa aggacaaagt   1020

aaatccagat gaatttgctg tggcacttga cgaaactctt ggagactttg cgttcccaga   1080

cgaatttgtc tttgatgttt ggggagtcat tggtgatgcc aaacgaagag gattatgatg   1140

tgtacactcc atctctgaag aaacaaccca tcgttctttt ttttctcttt tttaaaaagt   1200

cctataagat ctgtttttgg acacctttac taactctggt ttaatttcat gtgtatggaa   1260

tatattcttt gaaatataat tttggtaatt ttgatttctg ggcacttttt aacattgctg   1320

atgtagtatg cttaagagaa atgacctaaa taaggatcaa ttgtaatatt cattcaaaag   1380

gtttttaaaa gtaagtttta aggagtattt ctcgacagat gattttcttc tccattaata   1440

cccatgcttt gtttttcaca tataaataga tgatttcaat agctttgtag ttttttttca   1500

aaatcttaat gtaaactagg attggagtat gatttacctc atagtatctt cactgtgtta   1560

tcctagtttg aacaggatat gttcaggaaa tgaaaggtga attatgcccc ttattggtct   1620

agaagcattg gttttttttt gatcctctga gtaagggaag gaagattcct gtggcatgtt   1680

gatttctatg gccaactttc tctctttgta aaacaaagat tgattgattt tcttgtatgc   1740

ttctttatac atgctcttaa aacttgtggt tgaaatctgt gctgtgtgtg tgtgtctctg   1800

catgtgtaaa agaagggtaa aaaagagatg ggtagggtag aactacttgc atttgatttt   1860

tttttcagtc cttaaaacat tatttctttt tttcactcat agccactttt atgttacctt   1920

ttataagcac tccagggaag attttatatt tttttgtaga gtttttggaa agatatttac   1980

tcaaaataac tatgctttag aacttttttt tttttttttt ttttggttaa acagcagcac   2040

tttttagttc cctaaacttt agaagaaatg ctatcagaaa tagatttcct tccagtggaa   2100

agaaaggagg aagggagaat tgagaaaata tattagtcta ttattttaga gttctaatac   2160

actctaaatt aaagagaaaa ttgagagtaa atgactgtct tatcactctt atttgacatt   2220

tcgtaggtgt aagagaaatg gaaatgaatg gtttcaacaa agatcattta atacagcaga   2280

gcatggcatg accaagcatc tttgtaaagt gttagatgga aaatgctgtg tgctgccatg   2340

gtaatcagaa ataataacct gttagggatg tattctagga aatcagaagt agttctcttt   2400

tcttgctgga ttattgctta gataactctt gttttctggt aaaactttag ttgtattgcc   2460

atccactcct ttttcaaatg agtttaatgc cataaagctg atattctttg tccgattaat   2520

ttgaaatctg cacagaagct gttttagtca ttaatgtgta acaaaagtag cttatagaat   2580

atggactgcc ttattgctgt tgcttatcat ttgaaaataa aatccagctc aggttgtaac   2640

ttgttggtac tcgtttagtg agttcgtttt ggaggttctg aaatacctat taattcttaa   2700

tattacctct cttggaaaga cacaaaaaaa gagctgttat ttttaggcat aagatgactt   2760

aggaggccca tagaaacatt ctcgtttaaa caacaacaac aaaataaatt tatcagcact   2820

ag                                                                  2822


<210>  6524
<211>  315
<212>  PRT
<213>  Homosapiens

<400>  6524

Met Pro Leu Lys Leu Arg Gly Lys Lys Lys Ala Lys Ser Lys Glu Thr 
1               5                   10                  15      


Ala Gly Leu Val Glu Gly Glu Pro Thr Gly Ala Gly Gly Gly Ser Leu 
            20                  25                  30          


Ser Ala Ser Arg Ala Pro Ala Arg Arg Leu Val Phe His Ala Gln Leu 
        35                  40                  45              


Ala His Gly Ser Ala Thr Gly Arg Val Glu Gly Phe Ser Ser Ile Gln 
    50                  55                  60                  


Glu Leu Tyr Ala Gln Ile Ala Gly Ala Phe Glu Ile Ser Pro Ser Glu 
65                  70                  75                  80  


Ile Leu Tyr Cys Thr Leu Asn Thr Pro Lys Ile Asp Met Glu Arg Leu 
                85                  90                  95      


Leu Gly Gly Gln Leu Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
            100                 105                 110         


Gly Ile Glu Lys Glu Val Asn Val Tyr Lys Ser Glu Asp Ser Leu Gly 
        115                 120                 125             


Leu Thr Ile Thr Asp Asn Gly Val Gly Tyr Ala Phe Ile Lys Arg Ile 
    130                 135                 140                 


Lys Asp Gly Gly Val Ile Asp Ser Val Lys Thr Ile Cys Val Gly Asp 
145                 150                 155                 160 


His Ile Glu Ser Ile Asn Gly Glu Asn Ile Val Gly Trp Arg His Tyr 
                165                 170                 175     


Asp Val Ala Lys Lys Leu Lys Glu Leu Lys Lys Glu Glu Leu Phe Thr 
            180                 185                 190         


Met Lys Leu Ile Glu Pro Lys Lys Ala Phe Glu Ile Glu Leu Arg Ser 
        195                 200                 205             


Lys Ala Gly Lys Ser Ser Gly Glu Lys Ile Gly Cys Gly Arg Ala Thr 
    210                 215                 220                 


Leu Arg Leu Arg Ser Lys Gly Pro Ala Thr Val Glu Glu Met Pro Ser 
225                 230                 235                 240 


Glu Thr Lys Ala Lys Ala Ile Glu Lys Ile Asp Asp Val Leu Glu Leu 
                245                 250                 255     


Tyr Met Gly Ile Arg Asp Ile Asp Leu Ala Thr Thr Met Phe Glu Ala 
            260                 265                 270         


Gly Lys Asp Lys Val Asn Pro Asp Glu Phe Ala Val Ala Leu Asp Glu 
        275                 280                 285             


Thr Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp Val Trp 
    290                 295                 300                 


Gly Val Ile Gly Asp Ala Lys Arg Arg Gly Leu 
305                 310                 315 


<210>  6525
<211>  2633
<212>  DNA
<213>  Homosapiens

<400>  6525
gggcgggcgg ctgctccggt ccaggggtgg aggtcggggc cctgacccga cgcagccagg     60

cggaagcgcg gctgccattg gaggctgctt ttacctgcgc ggggcccggg gcgcaaagtc    120

cgaggcgccg gggggaggag gcggcggacg gcagcgcagg tgggcccgcg ctctcggccc    180

tgcaagatgc ccctgaagct gcgggggaag aagaaggcca agtccaagga gaccgccggg    240

ctggtggagg gcgagccgac gggcgcgggc ggcgggagcc tctcagcgtc ccgggctccc    300

gcacgcaggc tggtcttcca cgcgcagctg gcgcacggta gtgccacggg ccgagtggag    360

ggcttctcca gcatccagga gctctacgcc cagatcgcgg gcgcgtttga aatctcgccg    420

tcggagatct tatattgcac tttaaacaca cctaaaattg acatggaaag actcttagga    480

ggacaactag gactagaaga tttcatattt gcccatgtga aaggaatcga aaaagaagtg    540

aatgtgtata aatctgagga ttcacttggt ctcaccatta cagataatgg tgttggctat    600

gcttttataa agagaattaa agatggtggt gttattgact cagttaaaac aatctgtgtt    660

ggggatcata ttgaatccat aaatggagaa aatattgttg ggtggcgtca ctatgatgtt    720

gctaagaagt taaaggaatt aaaaaaggag gaactcttta ctatgaagtt aatagaacct    780

aagaaggcat ttgaaataga gctgaggtca aaggctggaa agtcatcagg agaaaaaatt    840

ggttgtggaa gggcaacact tcgcctgaga tcaaaaggtc ctgccaccgt ggaagaaatg    900

ccttctgaaa ccaaagcaaa ggcaattgaa aagattgatg atgttcttga gttgtacatg    960

ggaattcgag atattgattt agccaccaca atgtttgaag ctggaaagga caaagtaaat   1020

ccagatgaat ttgctgtggc acttgacgaa actcttggag actttgcgtt cccagacgaa   1080

tttgtctttg atgtttgggg agtcattggt gatgccaaac gaagaggatt atgatgtgta   1140

cactccatct ctgaagaaac aacccatcgt tctttttttt ctctttttta aaaagtccta   1200

taagatctgt ttttggacac ctttactaac tctggtttaa tttcatgtgt atggaatata   1260

ttctttgaaa tataattttg gtaattttga tttctgggca ctttttaaca ttgctgatgt   1320

agtatgctta agagaaatga cctaaataag gatcaattgt aatattcatt caaaaggttt   1380

ttaaaagtaa gttttaagga gtatttctcg acagatgatt ttcttctcca ttaataccca   1440

tgctttgttt ttcacatata aatagatgat ttcaatagct ttgtagtttt ttttcaaaat   1500

cttaatgtaa actaggattg gagtatgatt tacctcatag tatcttcact gtgttatcct   1560

agtttgaaca ggatatgttc aggaaatgaa aggtgaatta tgccccttat tggtctagaa   1620

gcattggttt ttttttgatc ctctgagtaa gggaaggaag attcctgtgg catgttgatt   1680

tctatggcca actttctctc tttgtaaaac aaagattgat tgattttctt gtatgcttct   1740

ttatacatgc tcttaaaact tgtggttgaa atctgtgctg tgtgtgtgtg tctctgcatg   1800

tgtaaaagaa gggtaaaaaa gagatgggta gggtagaact acttgcattt gatttttttt   1860

tcagtcctta aaacattatt tctttttttc actcatagcc acttttatgt taccttttat   1920

aagcactcca gggaagattt tatatttttt tgtagagttt ttggaaagat atttactcaa   1980

aataactatg ctttagaact tttttttttt tttttttttt ggttaaacag cagcactttt   2040

tagttcccta aactttagaa gaaatgctat cagaaataga tttccttcca gtggaaagaa   2100

aggaggaagg gagaattgag aaaatatatt agtctattat tttagagttc taatacactc   2160

taaattaaag agaaaattga gagtaaatga ctgtcttatc actcttattt gacatttcgt   2220

aggtgtaaga gaaatggaaa tgaatggttt caacaaagat catttaatac agcagagcat   2280

ggcatgacca agcatctttg taaagtgtta gatggaaaat gctgtgtgct gccatggtaa   2340

tcagaaataa taacctgtta gggatgtatt ctaggaaatc agaagtagtt ctcttttctt   2400

gctggattat tgcttagata actcttgttt tctggtaaaa ctttagttgt attgccatcc   2460

actccttttt caaatgagtt taatgccata aagctgatat tctttgtccg attaatttga   2520

aatctgcaca gaagctgttt tagtcattaa tgtgtaacaa aagtagctta tagaatatgg   2580

actgccttat tgctgttgct tatcatttga aaataaaatc cagctcaggt tgt          2633


<210>  6526
<211>  315
<212>  PRT
<213>  Homosapiens

<400>  6526

Met Pro Leu Lys Leu Arg Gly Lys Lys Lys Ala Lys Ser Lys Glu Thr 
1               5                   10                  15      


Ala Gly Leu Val Glu Gly Glu Pro Thr Gly Ala Gly Gly Gly Ser Leu 
            20                  25                  30          


Ser Ala Ser Arg Ala Pro Ala Arg Arg Leu Val Phe His Ala Gln Leu 
        35                  40                  45              


Ala His Gly Ser Ala Thr Gly Arg Val Glu Gly Phe Ser Ser Ile Gln 
    50                  55                  60                  


Glu Leu Tyr Ala Gln Ile Ala Gly Ala Phe Glu Ile Ser Pro Ser Glu 
65                  70                  75                  80  


Ile Leu Tyr Cys Thr Leu Asn Thr Pro Lys Ile Asp Met Glu Arg Leu 
                85                  90                  95      


Leu Gly Gly Gln Leu Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
            100                 105                 110         


Gly Ile Glu Lys Glu Val Asn Val Tyr Lys Ser Glu Asp Ser Leu Gly 
        115                 120                 125             


Leu Thr Ile Thr Asp Asn Gly Val Gly Tyr Ala Phe Ile Lys Arg Ile 
    130                 135                 140                 


Lys Asp Gly Gly Val Ile Asp Ser Val Lys Thr Ile Cys Val Gly Asp 
145                 150                 155                 160 


His Ile Glu Ser Ile Asn Gly Glu Asn Ile Val Gly Trp Arg His Tyr 
                165                 170                 175     


Asp Val Ala Lys Lys Leu Lys Glu Leu Lys Lys Glu Glu Leu Phe Thr 
            180                 185                 190         


Met Lys Leu Ile Glu Pro Lys Lys Ala Phe Glu Ile Glu Leu Arg Ser 
        195                 200                 205             


Lys Ala Gly Lys Ser Ser Gly Glu Lys Ile Gly Cys Gly Arg Ala Thr 
    210                 215                 220                 


Leu Arg Leu Arg Ser Lys Gly Pro Ala Thr Val Glu Glu Met Pro Ser 
225                 230                 235                 240 


Glu Thr Lys Ala Lys Ala Ile Glu Lys Ile Asp Asp Val Leu Glu Leu 
                245                 250                 255     


Tyr Met Gly Ile Arg Asp Ile Asp Leu Ala Thr Thr Met Phe Glu Ala 
            260                 265                 270         


Gly Lys Asp Lys Val Asn Pro Asp Glu Phe Ala Val Ala Leu Asp Glu 
        275                 280                 285             


Thr Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp Val Trp 
    290                 295                 300                 


Gly Val Ile Gly Asp Ala Lys Arg Arg Gly Leu 
305                 310                 315 


<210>  6527
<211>  241
<212>  DNA
<213>  Homosapiens

<400>  6527
tttgcagatc ttatattgca ctttaaacac acctaaaatt gacatggaaa gactcttagg     60

aggacaacta ggactagaag atttcatatt tgcccatgtg aaaggaatcg aaaaagaagt    120

gaatgtgtat aaatctgagg attcacttgg tctcaccatt acagataatg gtgttggcta    180

tgcttttata aagattctta tctgctgcct ctgatagtga aatgtgctgt gacttttctc    240

t                                                                    241


<210>  6528
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  6528

Met Glu Arg Leu Leu Gly Gly Gln Leu Gly Leu Glu Asp Phe Ile Phe 
1               5                   10                  15      


Ala His Val Lys Gly Ile Glu Lys Glu Val Asn Val Tyr Lys Ser Glu 
            20                  25                  30          


Asp Ser Leu Gly Leu Thr Ile Thr Asp Asn Gly Val Gly Tyr Ala Phe 
        35                  40                  45              


Ile Lys Ile Leu Ile Cys Cys Leu 
    50                  55      


<210>  6529
<211>  455
<212>  DNA
<213>  Homosapiens

<400>  6529
gttggagcag gctggaaggc gtaggcctca gggtcagtgg agtctcaagt tctcctttct     60

tgcagcctcc tgtgacactc gtggactggc acagaactag atgtacccta gagctatgct    120

catgctatgg gaccccaccc atgtctctcc ttttatggga caagcataag catatcctta    180

atagggaaaa tgaacaccaa ggctctggca gcaggcagga tgagcatagg tgccagctgg    240

ttggaagctt gtgagaaaac agtggctgcc cagaacactt ggaaacctgg gaggactgtg    300

tattagtcca ttctttcact gctataaata tgctacctga aactgggtaa tttataaaga    360

aaggatgctt aattgagtca cagttttgct ggctagggag gcctcaggaa aatgtgagtc    420

aattaaacct ctttacttta taaattaccc agtct                               455


<210>  6530
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  6530

Met Gly Pro His Pro Cys Leu Ser Phe Tyr Gly Thr Ser Ile Ser Ile 
1               5                   10                  15      


Ser Leu Ile Gly Lys Met Asn Thr Lys Ala Leu Ala Ala Gly Arg Met 
            20                  25                  30          


Ser Ile Gly Ala Ser Trp Leu Glu Ala Cys Glu Lys Thr Val Ala Ala 
        35                  40                  45              


Gln Asn Thr Trp Lys Pro Gly Arg Thr Val Tyr 
    50                  55                  


<210>  6531
<211>  1993
<212>  DNA
<213>  Homosapiens

<400>  6531
attgctgatt tggtaaccac ctcagagcct accctattta ttcccagcat ggacctaaat     60

ccacttcagc caaaaatgaa caaagaaatg atgaagaaca gagcctgttt ctttctcagt    120

ggtgtactca gaaaatggat gcaagagtag aagctgatcc tcgaggcttg caaaagtggg    180

gttctttctg aaagtgaagc cagcagccaa gagccaccct tcagaagata gaaggaagag    240

cagctgcatg agtgatggcc acagcaatgc atgggtcctg tctgtccacg tagtcctctc    300

catctgcccg tagcttgcca ggtctcctac ccacactggg gaaattccag ctgccggccc    360

tctttgggtt gcacctcccc tttttgcaca gggctctatt gggaaagcag ctgtcatgtg    420

tctatttgaa agacaagaaa ccagtctagt tatagaaaag agatttagat tacatcagaa    480

taacaatgca aatcatttgt gcagttctta gtacagaaaa cagatttagg aacaaaaatt    540

gggagggtta aagaaagtgg ttttttattc tgtcatcaaa attgtttttt aaaaacacat    600

ctgtagtaag ataaataatt gtgtgccgac ttcataaaca gaatgaatga ctgaattcac    660

acaatgttat ttactgtttc agggcacaca cacatggttt ccaagtggtt tcttgccact    720

ttggccttca actggccttg ctattttcca ttgaggggtg tctgattgtc tcctccacag    780

ccctgagtct aagcaaaagc ccatgggttg gttgactggt gttcttgttg tccttggaag    840

tggacagact ggcagatgtg gggctagtgg ggaagattct cgtaaacact ttatttgttg    900

taagaactcc agttggaatg tggcttccaa tcatgggagg aggactgctt tagaacagga    960

aactttctat aataatacca atacaaccaa agactattat tctgaacaga aaacaagaaa   1020

tacagctgga gctatttcct atctacctga tgaagggcac taccaggcgg tcactctggc   1080

tctgtccacc gatgcctgtg cccactttgt gcgacgtagc ttccatggag acaagagcaa   1140

tggtaatgga agaagaaagt ctggatgtac tcttgcagaa gcagaaagct tcatggaaca   1200

atattaatct tctggtcatc tctgtgctgg tctagttgcc cataaagttg tcagattgac   1260

tttggattta aagcctgaaa atgagtccca aggaaatccg ttgacatgag gcccaaggaa   1320

gacagttttt ggaaggggca aggagggaca gttctctgct ccactgaagc taggtatggc   1380

catgtgaccc atgttgccag tgaaacagga ggagaaggga catctgggtg gaaacattta   1440

agagtcaagt gtatttctcc atactctctt tctttggctt tggcagtgat gaaggtcaat   1500

ccaattacag ttgattcttg aacaacagag gtttgaactg tgtgggtcaa cctatacgtg   1560

gattttcttc tgcctctgcc acctctgaga cagcaagacc aatccttcct tttcctcctt   1620

ctcctcagcc tatacaatgt aaaaatgaca aggatgaaga cctttatgat gattcacgtc   1680

cacttaatga acaacgtacc tttcacttcc caccatgatt ctgaggcctc ccgagccatg   1740

tggaactgta agtgcaatta aacctctttt tcttcccagt cttgggtatg tctttatcag   1800

cagtgtgaaa atggactaat acagtaaata ggtaccagta gagtggggca ttgctgaaaa   1860

gatatctgaa aatgtggaag caacttttga actgggtaac aggcagaggt tggaagagtt   1920

tggagggctc agaagaagac aggaaaatgt gggaaagttt ggaacttcta gagatttgtt   1980

gaatggcttt gac                                                      1993


<210>  6532
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  6532

Met Gly Trp Leu Thr Gly Val Leu Val Val Leu Gly Ser Gly Gln Thr 
1               5                   10                  15      


Gly Arg Cys Gly Ala Ser Gly Glu Asp Ser Arg Lys His Phe Ile Cys 
            20                  25                  30          


Cys Lys Asn Ser Ser Trp Asn Val Ala Ser Asn His Gly Arg Arg Thr 
        35                  40                  45              


Ala Leu Glu Gln Glu Thr Phe Tyr Asn Asn Thr Asn Thr Thr Lys Asp 
    50                  55                  60                  


Tyr Tyr Ser Glu Gln Lys Thr Arg Asn Thr Ala Gly Ala Ile Ser Tyr 
65                  70                  75                  80  


Leu Pro Asp Glu Gly His Tyr Gln Ala Val Thr Leu Ala Leu Ser Thr 
                85                  90                  95      


Asp Ala Cys Ala His Phe Val Arg Arg Ser Phe His Gly Asp Lys Ser 
            100                 105                 110         


Asn Gly Asn Gly Arg Arg Lys Ser Gly Cys Thr Leu Ala Glu Ala Glu 
        115                 120                 125             


Ser Phe Met Glu Gln Tyr 
    130                 


<210>  6533
<211>  1166
<212>  DNA
<213>  Homosapiens

<400>  6533
agagcctacc ctatttattc ccagcatgga cctaaatcca cttcagccaa aaatgaacaa     60

agaaatgatg aagaacagag cctgtttctt tctcagtggt gtactcagaa aatggatgca    120

agagtagaag ctgatcctcg aggcttgcaa aagtggggtt ctttctgaaa gtgaagccag    180

cagccaagag ccacccttca gaagatagaa ggaagagcag ctgcatgagt gatggccaca    240

gcaatgcatg ggtcctgtct gtccacgtag tcctctccat ctgcccgtag cttgccagga    300

aactttctat aataatacca atacaaccaa agactattat tctgaacaga aaacaagaaa    360

tacagctgga gctatttcct atctacctga tgaagggcac taccaggcgg tcactctggc    420

tctgtccacc gatgcctgtg cccactttgt gcgacgtagc ttccatggag acaagagcaa    480

tggtaatgga agaagaaagt ctggatgtac tcttgcagaa gcagaaagct tcatggaaca    540

atattaatct tctggtcatc tctgtgctgg tctagttgcc cataaagttg tcagattgac    600

tttggattta aagcctgaaa atgagtccca aggaaatccg ttgacatgag gcccaaggaa    660

gacagttttt ggaaggggca agcataatga tttggaatga tgcctaataa aataaatggt    720

tgaccagaag attaataatg tgttggtttc tcaatagaag aggaggaaaa catgttttta    780

agattcttac caataaggct cactccaccc agtcctgtga ctcatgactc acctccaatc    840

aagagatgga ctcagctcat gaggaccatt ttccataccc ctatgactgc ctccgcaacc    900

aaccagcaac acccatcacc tagtcacctg cccaccatac tatccttgaa aatctctaat    960

cttcaagcct tcagggagac tgatttgaaa caaaagggac cctagaaatc ttcagccatc   1020

caaaagaagg caaaaaaaag agtatcaagg aaagaggatg gcaaacagaa aatgtaaaag   1080

aagatggtag aaatcacttc aagttggtaa tcacaatata tgtaaatata ttaaacacat   1140

ccattaaaag gctatgtgat tagatt                                        1166


<210>  6534
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  6534

Met Gly Pro Val Cys Pro Arg Ser Pro Leu His Leu Pro Val Ala Cys 
1               5                   10                  15      


Gln Glu Thr Phe Tyr Asn Asn Thr Asn Thr Thr Lys Asp Tyr Tyr Ser 
            20                  25                  30          


Glu Gln Lys Thr Arg Asn Thr Ala Gly Ala Ile Ser Tyr Leu Pro Asp 
        35                  40                  45              


Glu Gly His Tyr Gln Ala Val Thr Leu Ala Leu Ser Thr Asp Ala Cys 
    50                  55                  60                  


Ala His Phe Val Arg Arg Ser Phe His Gly Asp Lys Ser Asn Gly Asn 
65                  70                  75                  80  


Gly Arg Arg Lys Ser Gly Cys Thr Leu Ala Glu Ala Glu Ser Phe Met 
                85                  90                  95      


Glu Gln Tyr 
            


<210>  6535
<211>  1711
<212>  DNA
<213>  Homosapiens

<400>  6535
catgaggaaa tgtagctgta tgcctggagg gatctacagc cagaccagcc aactcagcct     60

ggttaagaac acctgttgaa gaactagtgc aggcgtttgg aggacatagg acactctggc    120

catatgtctg gactgcaatc ctgcacagtt ttgagaggga gatgacttga gtggttggct    180

tttatctcca caacaatgtc catgaacaat tccaaacagc tagtgtctcc tgcagctgcg    240

cttctttcaa acacaacctg ccagacggaa aaccggcttt ccgtattttt ttcagtaatc    300

ttcatgacag tgggaatctt gtcaaacagc cttgccatcg ccattctcat gaaggcatat    360

cagagattta gacagaagtc caaggcatcg tttctgcttt tggccagtgg cctggtaatc    420

actgatttct ttggccatct catcaatgga gccatagcag tatttgtata tgcttctgat    480

aaagaatgga tccgctttga ccaatcaaat gtcctttgca gtatttttgg tatctgcatg    540

gtgttttctg gtctgtgccc acttcttcta ggcagtgtga tggccattga gcggtgtatt    600

ggagtcacaa aaccaatatt tcattctacg aaaattacat ccaaacatgt gaaaatgatg    660

ttaagtggtg tgtgcttgtt tgctgttttc atagctttgc tgcccatcct tggacatcga    720

gactataaaa ttcaggcgtc gaggacctgg tgtttctaca acacagaaga catcaaagac    780

tgggaagata gattttatct tctacttttt tcttttctgg ggctcttagc ccttggtgtt    840

tcattgttgt gcaatgcaat cacaggaatt acacttttaa gagttaaatt taaaagtcag    900

cagcacagac aaggcagatc tcatcatttg gaaatggtaa tccagctcct ggcgataatg    960

tgtgtctcct gtatttgttg gagcccattt ctggttacaa tggccaacat tggaataaat   1020

ggaaatcatt ctctggaaac ctgtgaaaca acactttttg ctctccgaat ggcaacatgg   1080

aatcaaatct tagatccttg ggtatatatt cttctacgaa aggctgtcct taagaatctc   1140

tataagcttg ccagtcaatg ctgtggagtg catgtcatca gcttacatat ttgggagctt   1200

agttccatta aaaattcctt aaaggttgct gctatttctg agtcaccagt tgcagagaaa   1260

tcagcaagca cctagcttaa taggacagta aatctgtgtg gggctagaac aaaattaaga   1320

catgtttggc aatatttcag ttagttaaat acctgtagcc taactggaaa attcaggctt   1380

catcatgtag tttgaagata ctattgtcag attcaggttt tgaaatttgt caaataaaca   1440

ggataactgt acatttttca cttgtttttg ccaatgggag gtagacacaa taaaataatg   1500

ccatgggagt cacactgaaa gcaattttga gcttatctgt cttatttatg ctttgagtga   1560

atcatctgtt gaggtctaat gcctttactt ggcctatttg ccagagaaca tcttaatgca   1620

gcctgcatag tgaaatggtt attttgagat caccgctctg tagctaaccc ttataaacta   1680

ggctcagtaa aataaagcac tcttattttt t                                  1711


<210>  6536
<211>  359
<212>  PRT
<213>  Homosapiens

<400>  6536

Met Ser Met Asn Asn Ser Lys Gln Leu Val Ser Pro Ala Ala Ala Leu 
1               5                   10                  15      


Leu Ser Asn Thr Thr Cys Gln Thr Glu Asn Arg Leu Ser Val Phe Phe 
            20                  25                  30          


Ser Val Ile Phe Met Thr Val Gly Ile Leu Ser Asn Ser Leu Ala Ile 
        35                  40                  45              


Ala Ile Leu Met Lys Ala Tyr Gln Arg Phe Arg Gln Lys Ser Lys Ala 
    50                  55                  60                  


Ser Phe Leu Leu Leu Ala Ser Gly Leu Val Ile Thr Asp Phe Phe Gly 
65                  70                  75                  80  


His Leu Ile Asn Gly Ala Ile Ala Val Phe Val Tyr Ala Ser Asp Lys 
                85                  90                  95      


Glu Trp Ile Arg Phe Asp Gln Ser Asn Val Leu Cys Ser Ile Phe Gly 
            100                 105                 110         


Ile Cys Met Val Phe Ser Gly Leu Cys Pro Leu Leu Leu Gly Ser Val 
        115                 120                 125             


Met Ala Ile Glu Arg Cys Ile Gly Val Thr Lys Pro Ile Phe His Ser 
    130                 135                 140                 


Thr Lys Ile Thr Ser Lys His Val Lys Met Met Leu Ser Gly Val Cys 
145                 150                 155                 160 


Leu Phe Ala Val Phe Ile Ala Leu Leu Pro Ile Leu Gly His Arg Asp 
                165                 170                 175     


Tyr Lys Ile Gln Ala Ser Arg Thr Trp Cys Phe Tyr Asn Thr Glu Asp 
            180                 185                 190         


Ile Lys Asp Trp Glu Asp Arg Phe Tyr Leu Leu Leu Phe Ser Phe Leu 
        195                 200                 205             


Gly Leu Leu Ala Leu Gly Val Ser Leu Leu Cys Asn Ala Ile Thr Gly 
    210                 215                 220                 


Ile Thr Leu Leu Arg Val Lys Phe Lys Ser Gln Gln His Arg Gln Gly 
225                 230                 235                 240 


Arg Ser His His Leu Glu Met Val Ile Gln Leu Leu Ala Ile Met Cys 
                245                 250                 255     


Val Ser Cys Ile Cys Trp Ser Pro Phe Leu Val Thr Met Ala Asn Ile 
            260                 265                 270         


Gly Ile Asn Gly Asn His Ser Leu Glu Thr Cys Glu Thr Thr Leu Phe 
        275                 280                 285             


Ala Leu Arg Met Ala Thr Trp Asn Gln Ile Leu Asp Pro Trp Val Tyr 
    290                 295                 300                 


Ile Leu Leu Arg Lys Ala Val Leu Lys Asn Leu Tyr Lys Leu Ala Ser 
305                 310                 315                 320 


Gln Cys Cys Gly Val His Val Ile Ser Leu His Ile Trp Glu Leu Ser 
                325                 330                 335     


Ser Ile Lys Asn Ser Leu Lys Val Ala Ala Ile Ser Glu Ser Pro Val 
            340                 345                 350         


Ala Glu Lys Ser Ala Ser Thr 
        355                 


<210>  6537
<211>  580
<212>  DNA
<213>  Homosapiens

<400>  6537
acaggttcaa gtgatcttcc cacctcagcc tcccaggtag ctgggactat aagcgaagac     60

caccacactt ggctattttt tttttcagta gagatggggt ttcactatgt tgcccaggct    120

tgtctccaac tcatgagttc aagcaatctg cccatcttgg cctccaaaag tgctgagatt    180

tacagataac aaaatcctgg aaaagagatg ccaagtaact tttccaagat caatgatcta    240

gtaactggca gagctgggtg caaaccaaag tggtctgact ttggaactaa tatatgaaat    300

ataaatcatc ttttaagtgg agtggcccaa gaacacttta tatatgacct atagaaagaa    360

cactcaactc tttcctgaaa aacagtacca agttgaaggc tgaagaggga gtgaataaat    420

ggaaaagtat ttttttctta ggtaagaaga ctatattgca catgtacaca aattatgtta    480

tgtaccattt gttacacaaa cattttcaat agcaatgact gagaataccc tgagattcca    540

tctgtaaatg gacagtataa ataaatgtgg tatattcata                          580


<210>  6538
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  6538

Met Gly Phe His Tyr Val Ala Gln Ala Cys Leu Gln Leu Met Ser Ser 
1               5                   10                  15      


Ser Asn Leu Pro Ile Leu Ala Ser Lys Ser Ala Glu Ile Tyr Arg 
            20                  25                  30      


<210>  6539
<211>  1616
<212>  DNA
<213>  Homosapiens

<400>  6539
ggcgcgcgtc gagaggcgac ggcgggctgg cctggcgcgc tgcggcgctc gctcacccgc     60

tcccgaggaa gggcagtggg ccccgccgcc gcctcccaat ggcgaggctg cgggattgcc    120

tgccccgcct gatgctcacg ctccggtccc tgctcttctg gtccctggtc tactgctact    180

gcgggctctg cgcctccatc cacctgctca aacttttgtg gagcctcggc aaggggccgg    240

cgcagacctt ccggcggccc gcccgggagc accctcccgc gtgcctgagc gacccctcct    300

tgggcaccca ctgctacgtg cggatcaagg attcagggtt aagatttcac tatgttgctg    360

ctggagaaag aggcaaacca cttatgctgc tgcttcatgg atttccagaa ttctggtatt    420

cttggcgtta ccaactgaga gaatttaaaa gtgaatatcg agttgtagca ctggatttga    480

gaggttatgg agaaacagat gctcccattc atcgacagaa ttataaattg gattgtctaa    540

ttacagatat aaaggatatt ttagattctt tagggtatag caaatgtgtt cttattggcc    600

atgactgggg gggcatgatt gcttggctaa ttgccatctg ttatcctgaa atggtgatga    660

agcttattgt tattaacttc cctcatccaa atgtatttac agaatatatt ttacgacacc    720

ctgctcagct gttgaaatcc agttattatt acttcttcca aataccatgg ttcccagaat    780

ttatgttctc aataaatgat ttcaaggttt tgaaacatct gtttaccagt cacagcactg    840

gcattggaag aaaaggatgc caattaacaa cagaggatct tgaagcttat atttatgtct    900

tttctcagcc tggagcatta agtggcccaa ttaaccatta ccgaaatatc ttcagctgcc    960

tgcctctcaa acatcacatg gtgaccactc caacactact actgtgggga gagaatgacg   1020

cattcatgga ggttgagatg gctgaagtca caaagattta tgttaaaaac tatttcaggc   1080

taactatttt gtcagaagcc agtcattggc ttcagcaaga ccaacctgac atagtgaaca   1140

aattgatatg gacatttcta aaagaagaaa caagaaaaaa agattgactt ttctttatct   1200

tctatgaagg gtctgtaatg aaatctctaa ataattttta aaaattgttc atcaacttct   1260

ttatgtttta ttagaaaaaa actgttttaa tgtgctttat cataaataaa tatcctgaca   1320

aatggtattg aaaaaaatct gagatcatgt gaacatataa tacaatgttg attttcttct   1380

ggtgtatttt gcacagacaa gcatctgcct taaaatatat acacttgtac aaaaaggaag   1440

tttggagtaa gtgcttccat tttggtttct tgcttttttt tactctgtta acatatggtg   1500

ccttttacaa atgtatatta aagattagct gtgccatatt ataaggcaaa cctgaaataa   1560

tataaatttt cattctattg ttcaaaaatt ctttttacta tttttaacca ttaaaa       1616


<210>  6540
<211>  362
<212>  PRT
<213>  Homosapiens

<400>  6540

Met Ala Arg Leu Arg Asp Cys Leu Pro Arg Leu Met Leu Thr Leu Arg 
1               5                   10                  15      


Ser Leu Leu Phe Trp Ser Leu Val Tyr Cys Tyr Cys Gly Leu Cys Ala 
            20                  25                  30          


Ser Ile His Leu Leu Lys Leu Leu Trp Ser Leu Gly Lys Gly Pro Ala 
        35                  40                  45              


Gln Thr Phe Arg Arg Pro Ala Arg Glu His Pro Pro Ala Cys Leu Ser 
    50                  55                  60                  


Asp Pro Ser Leu Gly Thr His Cys Tyr Val Arg Ile Lys Asp Ser Gly 
65                  70                  75                  80  


Leu Arg Phe His Tyr Val Ala Ala Gly Glu Arg Gly Lys Pro Leu Met 
                85                  90                  95      


Leu Leu Leu His Gly Phe Pro Glu Phe Trp Tyr Ser Trp Arg Tyr Gln 
            100                 105                 110         


Leu Arg Glu Phe Lys Ser Glu Tyr Arg Val Val Ala Leu Asp Leu Arg 
        115                 120                 125             


Gly Tyr Gly Glu Thr Asp Ala Pro Ile His Arg Gln Asn Tyr Lys Leu 
    130                 135                 140                 


Asp Cys Leu Ile Thr Asp Ile Lys Asp Ile Leu Asp Ser Leu Gly Tyr 
145                 150                 155                 160 


Ser Lys Cys Val Leu Ile Gly His Asp Trp Gly Gly Met Ile Ala Trp 
                165                 170                 175     


Leu Ile Ala Ile Cys Tyr Pro Glu Met Val Met Lys Leu Ile Val Ile 
            180                 185                 190         


Asn Phe Pro His Pro Asn Val Phe Thr Glu Tyr Ile Leu Arg His Pro 
        195                 200                 205             


Ala Gln Leu Leu Lys Ser Ser Tyr Tyr Tyr Phe Phe Gln Ile Pro Trp 
    210                 215                 220                 


Phe Pro Glu Phe Met Phe Ser Ile Asn Asp Phe Lys Val Leu Lys His 
225                 230                 235                 240 


Leu Phe Thr Ser His Ser Thr Gly Ile Gly Arg Lys Gly Cys Gln Leu 
                245                 250                 255     


Thr Thr Glu Asp Leu Glu Ala Tyr Ile Tyr Val Phe Ser Gln Pro Gly 
            260                 265                 270         


Ala Leu Ser Gly Pro Ile Asn His Tyr Arg Asn Ile Phe Ser Cys Leu 
        275                 280                 285             


Pro Leu Lys His His Met Val Thr Thr Pro Thr Leu Leu Leu Trp Gly 
    290                 295                 300                 


Glu Asn Asp Ala Phe Met Glu Val Glu Met Ala Glu Val Thr Lys Ile 
305                 310                 315                 320 


Tyr Val Lys Asn Tyr Phe Arg Leu Thr Ile Leu Ser Glu Ala Ser His 
                325                 330                 335     


Trp Leu Gln Gln Asp Gln Pro Asp Ile Val Asn Lys Leu Ile Trp Thr 
            340                 345                 350         


Phe Leu Lys Glu Glu Thr Arg Lys Lys Asp 
        355                 360         


<210>  6541
<211>  666
<212>  DNA
<213>  Homosapiens

<400>  6541
gctgctgctt catggatttc cagaattctg gtattcttgg cgttaccaac tgagagaatt     60

taaaagtgaa tatcgagttg tagcactgga tttgagaggt tatggagaaa cagatgctcc    120

cattcatcga cagaattata aattggattg tctaattaca gatataaagg atattttaga    180

ttctttaggt aggttagttt gaaacaaaac aactcttttt aagggacaaa cattcaacaa    240

attgtgaatc aatgacttct tttcttggga ggatgcatat tccatctacc caaattatct    300

ggatcctgtc actatggttt cagttagtca gcccaaaata tctgtacagg aaatttaaaa    360

tgatgcatct agagcaacta ttctgtctac cagccaagaa tgacttttca gatttgtttt    420

taaacataga cctaatggcc cgggtgctgt ggcttgcgcc tataatccca gcactttgag    480

aggctgaggc gggcagatca cctgaggtca gagtttaaga ccagcctgac caacatgttg    540

aaaccctgtc tctactaaaa atacaaaaat tagccaggcg tgaacccagg agatggaggt    600

tgcagtgagc taagatcgtg ccgttgcact ccaacctggg caacaagaat gagactctgt    660

ttaaaa                                                               666


<210>  6542
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  6542

Met Thr Ser Phe Leu Gly Arg Met His Ile Pro Ser Thr Gln Ile Ile 
1               5                   10                  15      


Trp Ile Leu Ser Leu Trp Phe Gln Leu Val Ser Pro Lys Tyr Leu Tyr 
            20                  25                  30          


Arg Lys Phe Lys Met Met His Leu Glu Gln Leu Phe Cys Leu Pro Ala 
        35                  40                  45              


Lys Asn Asp Phe Ser Asp Leu Phe Leu Asn Ile Asp Leu Met Ala Arg 
    50                  55                  60                  


Val Leu Trp Leu Ala Pro Ile Ile Pro Ala Leu 
65                  70                  75  


<210>  6543
<211>  949
<212>  DNA
<213>  Homosapiens

<400>  6543
atggccccta aacgccagtc tccactccca cttcaaaaga agaaaccaag accacctcct     60

gctctgggac tggaggagac atcggcctct gcaggcttgc cgaagaaggg agaaaaagaa    120

cagcaagaag caattgaaca cattgatgaa gtacaaaatg aaatagacag acttaatgaa    180

caagacagtg aggagatttt gaaagtagaa cagaaatata acaaactccg ccaaccattt    240

tttcagaaga ggtcagaatt gatcgccaaa atcccaaatt ttggggtaac aacatttgtc    300

aaccatccac aagtgtcttc actgcttggg gaggaggacg aagaggcact gcattatttg    360

actaaagttg aagtgacaga atttgaagat attaaatcag gttacagaat agatttttat    420

tttgatgaaa atccttactt tgaaaataaa gttttctcca aagaatttca tctgaatgag    480

agtggtgatc catcttcaaa gtccaccaaa atcaaatgga aatctggaaa ggatgtgacg    540

aaacgttcaa gtcaaacgca gaataaagcc agcaggaaga ggcagcatga ggaaccagag    600

agcttcttta cctggtttac tgatcattct gatgcaggtg ctgatgagtt agaagaggtc    660

atcaaagatg atatttggcc aaacccatta cagtattact tggttcctga tatggatgat    720

gaagaaggag gagaagatga tgatgatgat gatgatgatg gtgatgaagg ggaggaagaa    780

ttagaagata ttgatgaagg ggatgaggat gaaggtgaag aagatgaaga tgatgatgaa    840

ggggaggaag gagaggagga tgaaggagaa gatgactaat agaacactga tggactccaa    900

ccttcctttt ttaaaatttt ctccagccct gggagcaagt tgcagtctt                949


<210>  6544
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  6544

Met Ala Pro Lys Arg Gln Ser Pro Leu Pro Leu Gln Lys Lys Lys Pro 
1               5                   10                  15      


Arg Pro Pro Pro Ala Leu Gly Leu Glu Glu Thr Ser Ala Ser Ala Gly 
            20                  25                  30          


Leu Pro Lys Lys Gly Glu Lys Glu Gln Gln Glu Ala Ile Glu His Ile 
        35                  40                  45              


Asp Glu Val Gln Asn Glu Ile Asp Arg Leu Asn Glu Gln Asp Ser Glu 
    50                  55                  60                  


Glu Ile Leu Lys Val Glu Gln Lys Tyr Asn Lys Leu Arg Gln Pro Phe 
65                  70                  75                  80  


Phe Gln Lys Arg Ser Glu Leu Ile Ala Lys Ile Pro Asn Phe Gly Val 
                85                  90                  95      


Thr Thr Phe Val Asn His Pro Gln Val Ser Ser Leu Leu Gly Glu Glu 
            100                 105                 110         


Asp Glu Glu Ala Leu His Tyr Leu Thr Lys Val Glu Val Thr Glu Phe 
        115                 120                 125             


Glu Asp Ile Lys Ser Gly Tyr Arg Ile Asp Phe Tyr Phe Asp Glu Asn 
    130                 135                 140                 


Pro Tyr Phe Glu Asn Lys Val Phe Ser Lys Glu Phe His Leu Asn Glu 
145                 150                 155                 160 


Ser Gly Asp Pro Ser Ser Lys Ser Thr Lys Ile Lys Trp Lys Ser Gly 
                165                 170                 175     


Lys Asp Val Thr Lys Arg Ser Ser Gln Thr Gln Asn Lys Ala Ser Arg 
            180                 185                 190         


Lys Arg Gln His Glu Glu Pro Glu Ser Phe Phe Thr Trp Phe Thr Asp 
        195                 200                 205             


His Ser Asp Ala Gly Ala Asp Glu Leu Glu Glu Val Ile Lys Asp Asp 
    210                 215                 220                 


Ile Trp Pro Asn Pro Leu Gln Tyr Tyr Leu Val Pro Asp Met Asp Asp 
225                 230                 235                 240 


Glu Glu Gly Gly Glu Asp Asp Asp Asp Asp Asp Asp Asp Gly Asp Glu 
                245                 250                 255     


Gly Glu Glu Glu Leu Glu Asp Ile Asp Glu Gly Asp Glu Asp Glu Gly 
            260                 265                 270         


Glu Glu Asp Glu Asp Asp Asp Glu Gly Glu Glu Gly Glu Glu Asp Glu 
        275                 280                 285             


Gly Glu Asp Asp 
    290         


<210>  6545
<211>  1594
<212>  DNA
<213>  Homosapiens

<400>  6545
gccggcagaa gtaaacagag cgagtacgcc tgcgcacgct cttcctgggt caagagccgg     60

ctcggttctg ggattctgag gctccccacc gcggtccggc ttctctggga gactgtctac    120

aaaccgacga gaggcgtcaa ccttttaccc tagggggcgg atttgggtag gagccgagcg    180

ttcggtcgga aacgccccct tcttcctcct gggcggggca agtgaggcca agtactgggc    240

ctccagggcg tcgtacctct gtgagacatg gctcgctgtg gggaaggcag tgcggccccc    300

atggtacttc tggggtccgc tggagtttgc agtaaggggt tgcaaaggaa ggggccgtgt    360

gagcggcgcc ggctgaaggc gacggtgtcg gagcagctca gccaggattt gctcaggctt    420

ctaagggaag aattccatac agatgttacc ttctctgtgg gttgtacttt gttcaaagca    480

cacaaagcag tccttttagc aagagttcct gacttctatt ttcatactat tggacagaca    540

tcaaatagtt taacaaatca ggagcctatt gctgtggaga atgttgaagc tttagaattt    600

agaacgtttt tacagattat atattcatca aacagaaaca taaaaaacta tgaagaggaa    660

attcttagga aaaagataat ggagattggg atatcacaaa agcaacttga catcagtttt    720

ccaaagtgtg aaaactcatc tgattgttct cttcagaagc atgaaattcc agaggatatc    780

agtgacagag atgatgattt catttccaat gataattatg acttggagcc tgcatctgaa    840

ttaggagaag atttattgaa gctttatgtg aaaccttgtt gcccagatat tgatattttt    900

gttgatggaa aacgttttaa agctcacagg gccattttga gtgccagatc tagttatttt    960

gctgcaatgc tgagtggctg ttgggctgaa agctcccaag agtacgttac tcttcaaggt   1020

ataagccatg tagaactgaa tgttatgatg cattttatat atggaggaac tctggacatt   1080

ccagacaaaa ctaatgttgg gtatgtattc ctttttaata atttaaaata taaaagagtt   1140

aggttctgct ttgttgagct gtgttgcaaa gtgttaatga agtagaaact ttgcttttta   1200

tagtctatta tactatatct tcagtaggtt ttgagaacat ctaaaaacaa taagcaaatc   1260

atcttattta gaagaaaagg tgacttatca actcacagta ataagattga gaacagtctt   1320

tattagactt aaatttagaa gaagctataa attatggttt atagatcaat aaattgatta   1380

aacttttatc aaactttaaa aattactact ttttaaattt taggatatct tttctaaaca   1440

gcaaaagaaa agaaaaaaca tagttaagaa tataggggct gggtgcggtg gctctcgcct   1500

gtaatcccag cactttgtga ggctgaggcg gacggatcac aagatcaaga gatcgagacc   1560

atcctggcta acatggtgaa acctcgtctc tact                               1594


<210>  6546
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  6546

Met Ala Arg Cys Gly Glu Gly Ser Ala Ala Pro Met Val Leu Leu Gly 
1               5                   10                  15      


Ser Ala Gly Val Cys Ser Lys Gly Leu Gln Arg Lys Gly Pro Cys Glu 
            20                  25                  30          


Arg Arg Arg Leu Lys Ala Thr Val Ser Glu Gln Leu Ser Gln Asp Leu 
        35                  40                  45              


Leu Arg Leu Leu Arg Glu Glu Phe His Thr Asp Val Thr Phe Ser Val 
    50                  55                  60                  


Gly Cys Thr Leu Phe Lys Ala His Lys Ala Val Leu Leu Ala Arg Val 
65                  70                  75                  80  


Pro Asp Phe Tyr Phe His Thr Ile Gly Gln Thr Ser Asn Ser Leu Thr 
                85                  90                  95      


Asn Gln Glu Pro Ile Ala Val Glu Asn Val Glu Ala Leu Glu Phe Arg 
            100                 105                 110         


Thr Phe Leu Gln Ile Ile Tyr Ser Ser Asn Arg Asn Ile Lys Asn Tyr 
        115                 120                 125             


Glu Glu Glu Ile Leu Arg Lys Lys Ile Met Glu Ile Gly Ile Ser Gln 
    130                 135                 140                 


Lys Gln Leu Asp Ile Ser Phe Pro Lys Cys Glu Asn Ser Ser Asp Cys 
145                 150                 155                 160 


Ser Leu Gln Lys His Glu Ile Pro Glu Asp Ile Ser Asp Arg Asp Asp 
                165                 170                 175     


Asp Phe Ile Ser Asn Asp Asn Tyr Asp Leu Glu Pro Ala Ser Glu Leu 
            180                 185                 190         


Gly Glu Asp Leu Leu Lys Leu Tyr Val Lys Pro Cys Cys Pro Asp Ile 
        195                 200                 205             


Asp Ile Phe Val Asp Gly Lys Arg Phe Lys Ala His Arg Ala Ile Leu 
    210                 215                 220                 


Ser Ala Arg Ser Ser Tyr Phe Ala Ala Met Leu Ser Gly Cys Trp Ala 
225                 230                 235                 240 


Glu Ser Ser Gln Glu Tyr Val Thr Leu Gln Gly Ile Ser His Val Glu 
                245                 250                 255     


Leu Asn Val Met Met His Phe Ile Tyr Gly Gly Thr Leu Asp Ile Pro 
            260                 265                 270         


Asp Lys Thr Asn Val Gly Tyr Val Phe Leu Phe Asn Asn Leu Lys Tyr 
        275                 280                 285             


Lys Arg Val Arg Phe Cys Phe Val Glu Leu Cys Cys Lys Val Leu Met 
    290                 295                 300                 


Lys 
305 


<210>  6547
<211>  1410
<212>  DNA
<213>  Homosapiens

<400>  6547
gcgcacgctc ttcctgggtc aagagccggc tcggttctgg gattctgagg ctccccaccg     60

cggtccggct tctctgggag actgtctaca aaccgacgag aggcgtcaac cttttaccct    120

agggggcgga tttgggtagg agccgagcgt tcggtcggaa acgccccctt cttcctcctg    180

ggcggggcaa gtgaggccaa gtactgggcc tccagggcgt cgtacctctg tgagacatgg    240

ctcgctgtgg ggaaggcagt gcggccccca tggtacttct ggggtccgct ggagtttgca    300

gtaaggggtt gcaaaggaag gggccgtgtg agcggcgccg gctgaaggcg acggtgtcgg    360

agcagctcag ccaggatttg ctcaggcttc taagggaaga attccataca gatgttacct    420

tctctgtggg ttgtactttg ttcaaagcac acaaagcagt ccttttagca agagttcctg    480

acttctattt tcatactatt ggacagacat caaatagttt aacaaatcag gagcctattg    540

ctgtggagaa tgttgaagct ttagaattta gaacgttttt acagattata tattcatcaa    600

acagaaacat aaaaaactat gaagaggaaa ttcttaggaa aaagataatg gagattggga    660

tatcacaaaa gcaacttgac atcagttttc caaagtgtga aaactcatct gattgttctc    720

ttcagaagca tgaaattcca gaggatatca gtgacagaga tgatgatttc atttccaatg    780

ataattatga cttggagcct gcatctgaat taggagaaga tttattgaag ctttatgtga    840

aaccttgttg cccagatatt gatatttttg ttgatggaaa acgttttaaa gctcacaggg    900

ccattttgag tgccagatct agttattttg ctgcaatgct gagtggctgt tgggctgaaa    960

gctcccaaga gtacgttact cttcaaggta taagccatgt agaactgaat gttatgatgc   1020

attttatata tggaggaact ctggacattc cagacaaaac taatgttggt cagatactca   1080

atatggctga tatgtatgga ctagaaggat taaaagaagt agcaatctat attttaagaa   1140

gagattactg taatttcttt cagaagcctg ttcccagaac attgacgtct atactagaat   1200

gcctgattat tgctcattca gttggagtgg aaagtctttt tgctgactgc atgaagtgga   1260

ttgtaaagca ttttgcaagg ttttggtctg agagaagctt tgcaaatata cctcctgaga   1320

ttcagaaaag ttgtcttaat atgttgattc agtccttagt aagtataacc tgaatactct   1380

tttgtgtgtt tgccattaaa aagtttattc                                    1410


<210>  6548
<211>  378
<212>  PRT
<213>  Homosapiens

<400>  6548

Met Ala Arg Cys Gly Glu Gly Ser Ala Ala Pro Met Val Leu Leu Gly 
1               5                   10                  15      


Ser Ala Gly Val Cys Ser Lys Gly Leu Gln Arg Lys Gly Pro Cys Glu 
            20                  25                  30          


Arg Arg Arg Leu Lys Ala Thr Val Ser Glu Gln Leu Ser Gln Asp Leu 
        35                  40                  45              


Leu Arg Leu Leu Arg Glu Glu Phe His Thr Asp Val Thr Phe Ser Val 
    50                  55                  60                  


Gly Cys Thr Leu Phe Lys Ala His Lys Ala Val Leu Leu Ala Arg Val 
65                  70                  75                  80  


Pro Asp Phe Tyr Phe His Thr Ile Gly Gln Thr Ser Asn Ser Leu Thr 
                85                  90                  95      


Asn Gln Glu Pro Ile Ala Val Glu Asn Val Glu Ala Leu Glu Phe Arg 
            100                 105                 110         


Thr Phe Leu Gln Ile Ile Tyr Ser Ser Asn Arg Asn Ile Lys Asn Tyr 
        115                 120                 125             


Glu Glu Glu Ile Leu Arg Lys Lys Ile Met Glu Ile Gly Ile Ser Gln 
    130                 135                 140                 


Lys Gln Leu Asp Ile Ser Phe Pro Lys Cys Glu Asn Ser Ser Asp Cys 
145                 150                 155                 160 


Ser Leu Gln Lys His Glu Ile Pro Glu Asp Ile Ser Asp Arg Asp Asp 
                165                 170                 175     


Asp Phe Ile Ser Asn Asp Asn Tyr Asp Leu Glu Pro Ala Ser Glu Leu 
            180                 185                 190         


Gly Glu Asp Leu Leu Lys Leu Tyr Val Lys Pro Cys Cys Pro Asp Ile 
        195                 200                 205             


Asp Ile Phe Val Asp Gly Lys Arg Phe Lys Ala His Arg Ala Ile Leu 
    210                 215                 220                 


Ser Ala Arg Ser Ser Tyr Phe Ala Ala Met Leu Ser Gly Cys Trp Ala 
225                 230                 235                 240 


Glu Ser Ser Gln Glu Tyr Val Thr Leu Gln Gly Ile Ser His Val Glu 
                245                 250                 255     


Leu Asn Val Met Met His Phe Ile Tyr Gly Gly Thr Leu Asp Ile Pro 
            260                 265                 270         


Asp Lys Thr Asn Val Gly Gln Ile Leu Asn Met Ala Asp Met Tyr Gly 
        275                 280                 285             


Leu Glu Gly Leu Lys Glu Val Ala Ile Tyr Ile Leu Arg Arg Asp Tyr 
    290                 295                 300                 


Cys Asn Phe Phe Gln Lys Pro Val Pro Arg Thr Leu Thr Ser Ile Leu 
305                 310                 315                 320 


Glu Cys Leu Ile Ile Ala His Ser Val Gly Val Glu Ser Leu Phe Ala 
                325                 330                 335     


Asp Cys Met Lys Trp Ile Val Lys His Phe Ala Arg Phe Trp Ser Glu 
            340                 345                 350         


Arg Ser Phe Ala Asn Ile Pro Pro Glu Ile Gln Lys Ser Cys Leu Asn 
        355                 360                 365             


Met Leu Ile Gln Ser Leu Val Ser Ile Thr 
    370                 375             


<210>  6549
<211>  681
<212>  DNA
<213>  Homosapiens

<400>  6549
ggaaaacgtt ttaaagctca cagggccatt ttgagtgcca gatctagtta ttttgctgca     60

atgctgagtg gctgttgggc tgaaagctcc caagagtacg ttactcttca aggtataagc    120

catgtagaac tgaatgttat gatgcatttt atatatggag gaactctgga cattccagac    180

aaaactaatg ttggtcagat actcaatatg gctgatatgt atggactaga aggattaaaa    240

gaagtagcaa tctatatttt aagaagagat tactgtaatt tctttcagaa gcctgttccc    300

agaacattga cgtctatact agaatgcctg attattgctc attcagttgg agtggaaagt    360

ctttttgctg actgcatgaa gtggattgta aagcattttg caaggttttg gtctgagaga    420

agctttgcaa atatacctcc tgagattcag aaaagttgtc ttaatatgtt gattcagtcc    480

ttattgtggg tggctggagc ctgtctgcag ctaaggaccc aaggttggaa ccaaccctgg    540

acaggatacc attccagcgc agggtgcact cacagcacag aacactcact tatactggga    600

cattgtagag atgccagttc actaaatgtg cacatctttg ggatgtggga ggaaactgga    660

gtgtccagag aaaacccatg c                                              681


<210>  6550
<211>  206
<212>  PRT
<213>  Homosapiens

<400>  6550

Met Leu Ser Gly Cys Trp Ala Glu Ser Ser Gln Glu Tyr Val Thr Leu 
1               5                   10                  15      


Gln Gly Ile Ser His Val Glu Leu Asn Val Met Met His Phe Ile Tyr 
            20                  25                  30          


Gly Gly Thr Leu Asp Ile Pro Asp Lys Thr Asn Val Gly Gln Ile Leu 
        35                  40                  45              


Asn Met Ala Asp Met Tyr Gly Leu Glu Gly Leu Lys Glu Val Ala Ile 
    50                  55                  60                  


Tyr Ile Leu Arg Arg Asp Tyr Cys Asn Phe Phe Gln Lys Pro Val Pro 
65                  70                  75                  80  


Arg Thr Leu Thr Ser Ile Leu Glu Cys Leu Ile Ile Ala His Ser Val 
                85                  90                  95      


Gly Val Glu Ser Leu Phe Ala Asp Cys Met Lys Trp Ile Val Lys His 
            100                 105                 110         


Phe Ala Arg Phe Trp Ser Glu Arg Ser Phe Ala Asn Ile Pro Pro Glu 
        115                 120                 125             


Ile Gln Lys Ser Cys Leu Asn Met Leu Ile Gln Ser Leu Leu Trp Val 
    130                 135                 140                 


Ala Gly Ala Cys Leu Gln Leu Arg Thr Gln Gly Trp Asn Gln Pro Trp 
145                 150                 155                 160 


Thr Gly Tyr His Ser Ser Ala Gly Cys Thr His Ser Thr Glu His Ser 
                165                 170                 175     


Leu Ile Leu Gly His Cys Arg Asp Ala Ser Ser Leu Asn Val His Ile 
            180                 185                 190         


Phe Gly Met Trp Glu Glu Thr Gly Val Ser Arg Glu Asn Pro 
        195                 200                 205     


<210>  6551
<211>  4562
<212>  DNA
<213>  Homosapiens

<400>  6551
atggcgtctc agcttcaaga aaaatgtatt gcatttattg tagacaactt ctccaagatt     60

attcagagtg aaaattttgc tcttctttta cagtcacaag caatgagcag cacagccgat    120

ctgttggaca caattttaaa agcaattgaa gaaaatatca ccactgaaaa tagctgctct    180

cttcttatgg ctctggacac actgctgaac tctgacagta caaaggaaat gggttttacg    240

tgcaagatcc aggctctgcg tgataagctg tggatcttcc tggttcagtc tttctatgct    300

gttcgtcaca cagaaagctg gaagctgatg agcacagatg atcaacagaa aatccaagca    360

gctgcatttg acaaaggtga tgatcgaaga cttggcaaaa agcctatatt cagtagctcg    420

cagcaaagga aacaagtttc tgactctggt gatataaaaa tcaaatcttg gaggggaaat    480

aacaagaaag agtgttggag ttatctctct actaataaaa agatgaaatc tgatggatta    540

ggagcatctg gacattcgtc aagtaccaat agaaatagta taaataaaac tctgaagcaa    600

gatgatgtaa aggaaaaaga tggtacaaaa atagcatcta agattacaaa agaactaaaa    660

actgggggaa aaaatgtttc tggaaagccc aaaactgtaa caaaatccaa aacagaaaat    720

ggtgataagg cacggttgga aaacatgtca cctagacaag ttgtagaaag atcagcaaca    780

gcagcagcag cagcaactgg acagaagaat ttactaaatg gaaaaggagt gagaaatcag    840

gaagggcaaa tttcaggtgc cagacccaag gtactcacag gaaacttaaa tgtgcaagcc    900

aaagcaaagc ctttgaagaa agctacaggg aaggattcac catgcctcag catcgcagga    960

ccctccagca gatccacaga ttcaagtatg gaattctcaa tttccactga atgtctggat   1020

gaaccgaaag aaaatggatc aacagaagaa gaaaagcctt ctggacataa actatccttt   1080

tgtgattctc caggacagat gatgaaaaac agtgtagata gtgtcaaaaa ttccactgta   1140

gccataaaat ctcgacctgt ttcaagagtt accaatggaa cttccaataa aaaaagtatt   1200

catgaacaag acactaatgt aaataacagt gtactaaaga aagtcagtgg caaaggatgt   1260

agtgagccag taccacaggc aattttgaag aaaagaggaa ctagcaatgg atgtactgca   1320

gctcagcaga ggacaaagag taccccatct aatcttacta aaactcaagg atcccaagga   1380

gagtcaccaa actcagtaaa atcttcagtc tcttcaaggc agtctgatga aaatgtggca   1440

aagttggacc acaatacaac tacagagaaa caagcaccta agagaaaaat ggtcaagcaa   1500

gtacacacag ctttgcctaa ggttaatgca aaaatagtgg caatgcctaa aaatctaaat   1560

cagtcaaaga aaggtgaaac tttgaataat aaagattcaa aacagaaaat gcctcctgga   1620

caggttatat caaaaactca gccttcctcc caaagacctt taaaacatga aacatctact   1680

gtccaaaaaa gtatgtttca tgatgtgcgt gataataaca acaaggacag tgtttctgaa   1740

cagaagcctc acaaacctct cattaatctt gcatctgaaa taagtgatgc agaagcactc   1800

cagtcatcct gcaggcctga cccacaaaag ccattaaacg atcaagaaaa agagaagttg   1860

gcgttagaat gccaaaatat ttcaaagctg gataaatcat taaaacacga actggaatca   1920

aaacagattt gtttagataa aagtgaaaca aaatttccca atcacaaaga aacagatgat   1980

tgcgatgcag ctaacatatg ttgtcattct gttgggagtg ataatgtaaa ttcaaaattt   2040

tatagcacca cagccctaaa atacatggtt tcaaatccaa atgaaaactc cttgaactct   2100

aatccagttt gtgatttaga ctcaacaagt gcagggcaaa tccatttgat atcagatagg   2160

gagaaccaag tagggagaaa agatacaaac aaacaatcaa gtattaaatg tgtggaagat   2220

gtttcactgt gtaatcctga aaggacaaat ggtaccttaa attctgctca agaagacaaa   2280

aaatcgaaag ttcctgtgga aggactgaca attcctagta agttgtcaga tgaatctgct   2340

atggatgaag acaaacatgc tacagcagac tcagatgtat cttccaagtg tttttcggga   2400

cagctatcag aaaaaaattc tcctaaaaat atggaaacat cagaatctcc agagagccat   2460

gaaactccag aaactccatt tgtgggtcac tggaatttga gtactggtgt tctgcatcag   2520

cgagagagtc ctgaatctga cactggcagt gctaccacct cctccgatga cataaagccc   2580

agatctgaag actatgatgc tggagggtct caggatgatg atgggtcaaa tgacagaggt   2640

atctctaaat gtggcactat gctgtgccat gattttcttg gaagaagtag cagtgatacc   2700

agtactcctg aagaattaaa aatttatgat agtaatttaa gaattgaagt aaaaatgaaa   2760

aagcaaagta ataatgatct tttccaagtt aattcaacga gtgatgatga aatccctagg   2820

aaaaggccag aaatttggtc tcgatctgca atagttcact ctagggaaag agaaaatatt   2880

ccacgaggca gtgtccagtt tgctcaggaa atagatcagg tatcttcttc agcagatgaa   2940

acagaagatg aaagatctga agctgaaaac gttgcagaaa atttctctat atctaaccca   3000

gctcctcagc agtttcaggg aataattaat ttagcttttg aagatgcaac tgaaaatgaa   3060

tgtcgtgaat tttctgcaac taaaaagttt aaaaggtcag ttttactttc agtcgatgaa   3120

tgtgaagagc tgggatcaga tgaaggagaa gtccatactc cctttcaggc ttctgtagat   3180

tctttttcac cttctgatgt ttttgatggc atttctcatg aacatcatgg aaggacctgc   3240

tattccagat tctcacgaga aagtgaagat aatattttag aatgtaaaca aaataaaggc   3300

aatagtgtat gtaaaaatga aagcactgtc ttggatctta gtagcattga ctcttcaaga   3360

aaaaataaac agagtgtttc agccacagaa aaaaagaaca caatagacgt cctatccagt   3420

agaagcagac agcttcttcg agaagataaa aaagtaaaca atggaagcaa tgtggaaaat   3480

gacattcagc aacgcagcaa attcttggat agtgatgtaa aatctcaaga aagaccatgt   3540

cacttggatc ttcatcaaag agaacccaat tctgacatac caaagaacag ctctacaaaa   3600

tctctagact cctttcggag tcaagttctg cctcaggaag gtccagtgaa agagagccat   3660

tctacaacta ctgaaaaagc taatattgct ttatctgcag gagacataga tgattgtgac   3720

acactggcac aaacccgcat gtatgaccat cggccttcaa aaaccctgtc tccaatatat   3780

gagatggatg taatagaagc atttgagcag aaagtggaat cagaaacaca tgttacagat   3840

atggattttg aagatgacca acattttgca aaacaagatt ggacactact aaagcaactg   3900

ctctctgaac aggattcaaa cttagatgtt acaaattccg ttcctgaaga cttaagttta   3960

gcacagtatc taatcaatca gacactactt ttagcacgag atagctcaaa acctcagggt   4020

ataacacata ttgacacttt gaacagatgg agtgaactaa catctccact tgattcctca   4080

gcgagcatca ccatggctag tttttcctct gaagattgtt cgcctcaagg cgagtggaca   4140

attctggaac tggaaactca gcattaagtg ttaacatttt ggaaaaattt atgccactcc   4200

tttatttttt gatgcctata ttatatccaa atgataattg cattagccgg atataaactt   4260

tctttaatat tgagtctttc caatttaatg aggtaaacat agtttattta ttaatatatc   4320

acatatagaa aaatgttttt ctaaagtttt tgagcatgtt ttctctaatt attagagaaa   4380

ttagaagact tataaggaaa ccctagcttc agttttcctt tcctagctga tgatttgttc   4440

acttaatcat tattcaagaa tttaaaatgt gaatgcagaa gtagatcagt ccctttactt   4500

tttgctctgc atagggtaac atagtaattt aacaataaaa acttaccgtg cttgtgtcca   4560

tt                                                                  4562


<210>  6552
<211>  1388
<212>  PRT
<213>  Homosapiens

<400>  6552

Met Ala Ser Gln Leu Gln Glu Lys Cys Ile Ala Phe Ile Val Asp Asn 
1               5                   10                  15      


Phe Ser Lys Ile Ile Gln Ser Glu Asn Phe Ala Leu Leu Leu Gln Ser 
            20                  25                  30          


Gln Ala Met Ser Ser Thr Ala Asp Leu Leu Asp Thr Ile Leu Lys Ala 
        35                  40                  45              


Ile Glu Glu Asn Ile Thr Thr Glu Asn Ser Cys Ser Leu Leu Met Ala 
    50                  55                  60                  


Leu Asp Thr Leu Leu Asn Ser Asp Ser Thr Lys Glu Met Gly Phe Thr 
65                  70                  75                  80  


Cys Lys Ile Gln Ala Leu Arg Asp Lys Leu Trp Ile Phe Leu Val Gln 
                85                  90                  95      


Ser Phe Tyr Ala Val Arg His Thr Glu Ser Trp Lys Leu Met Ser Thr 
            100                 105                 110         


Asp Asp Gln Gln Lys Ile Gln Ala Ala Ala Phe Asp Lys Gly Asp Asp 
        115                 120                 125             


Arg Arg Leu Gly Lys Lys Pro Ile Phe Ser Ser Ser Gln Gln Arg Lys 
    130                 135                 140                 


Gln Val Ser Asp Ser Gly Asp Ile Lys Ile Lys Ser Trp Arg Gly Asn 
145                 150                 155                 160 


Asn Lys Lys Glu Cys Trp Ser Tyr Leu Ser Thr Asn Lys Lys Met Lys 
                165                 170                 175     


Ser Asp Gly Leu Gly Ala Ser Gly His Ser Ser Ser Thr Asn Arg Asn 
            180                 185                 190         


Ser Ile Asn Lys Thr Leu Lys Gln Asp Asp Val Lys Glu Lys Asp Gly 
        195                 200                 205             


Thr Lys Ile Ala Ser Lys Ile Thr Lys Glu Leu Lys Thr Gly Gly Lys 
    210                 215                 220                 


Asn Val Ser Gly Lys Pro Lys Thr Val Thr Lys Ser Lys Thr Glu Asn 
225                 230                 235                 240 


Gly Asp Lys Ala Arg Leu Glu Asn Met Ser Pro Arg Gln Val Val Glu 
                245                 250                 255     


Arg Ser Ala Thr Ala Ala Ala Ala Ala Thr Gly Gln Lys Asn Leu Leu 
            260                 265                 270         


Asn Gly Lys Gly Val Arg Asn Gln Glu Gly Gln Ile Ser Gly Ala Arg 
        275                 280                 285             


Pro Lys Val Leu Thr Gly Asn Leu Asn Val Gln Ala Lys Ala Lys Pro 
    290                 295                 300                 


Leu Lys Lys Ala Thr Gly Lys Asp Ser Pro Cys Leu Ser Ile Ala Gly 
305                 310                 315                 320 


Pro Ser Ser Arg Ser Thr Asp Ser Ser Met Glu Phe Ser Ile Ser Thr 
                325                 330                 335     


Glu Cys Leu Asp Glu Pro Lys Glu Asn Gly Ser Thr Glu Glu Glu Lys 
            340                 345                 350         


Pro Ser Gly His Lys Leu Ser Phe Cys Asp Ser Pro Gly Gln Met Met 
        355                 360                 365             


Lys Asn Ser Val Asp Ser Val Lys Asn Ser Thr Val Ala Ile Lys Ser 
    370                 375                 380                 


Arg Pro Val Ser Arg Val Thr Asn Gly Thr Ser Asn Lys Lys Ser Ile 
385                 390                 395                 400 


His Glu Gln Asp Thr Asn Val Asn Asn Ser Val Leu Lys Lys Val Ser 
                405                 410                 415     


Gly Lys Gly Cys Ser Glu Pro Val Pro Gln Ala Ile Leu Lys Lys Arg 
            420                 425                 430         


Gly Thr Ser Asn Gly Cys Thr Ala Ala Gln Gln Arg Thr Lys Ser Thr 
        435                 440                 445             


Pro Ser Asn Leu Thr Lys Thr Gln Gly Ser Gln Gly Glu Ser Pro Asn 
    450                 455                 460                 


Ser Val Lys Ser Ser Val Ser Ser Arg Gln Ser Asp Glu Asn Val Ala 
465                 470                 475                 480 


Lys Leu Asp His Asn Thr Thr Thr Glu Lys Gln Ala Pro Lys Arg Lys 
                485                 490                 495     


Met Val Lys Gln Val His Thr Ala Leu Pro Lys Val Asn Ala Lys Ile 
            500                 505                 510         


Val Ala Met Pro Lys Asn Leu Asn Gln Ser Lys Lys Gly Glu Thr Leu 
        515                 520                 525             


Asn Asn Lys Asp Ser Lys Gln Lys Met Pro Pro Gly Gln Val Ile Ser 
    530                 535                 540                 


Lys Thr Gln Pro Ser Ser Gln Arg Pro Leu Lys His Glu Thr Ser Thr 
545                 550                 555                 560 


Val Gln Lys Ser Met Phe His Asp Val Arg Asp Asn Asn Asn Lys Asp 
                565                 570                 575     


Ser Val Ser Glu Gln Lys Pro His Lys Pro Leu Ile Asn Leu Ala Ser 
            580                 585                 590         


Glu Ile Ser Asp Ala Glu Ala Leu Gln Ser Ser Cys Arg Pro Asp Pro 
        595                 600                 605             


Gln Lys Pro Leu Asn Asp Gln Glu Lys Glu Lys Leu Ala Leu Glu Cys 
    610                 615                 620                 


Gln Asn Ile Ser Lys Leu Asp Lys Ser Leu Lys His Glu Leu Glu Ser 
625                 630                 635                 640 


Lys Gln Ile Cys Leu Asp Lys Ser Glu Thr Lys Phe Pro Asn His Lys 
                645                 650                 655     


Glu Thr Asp Asp Cys Asp Ala Ala Asn Ile Cys Cys His Ser Val Gly 
            660                 665                 670         


Ser Asp Asn Val Asn Ser Lys Phe Tyr Ser Thr Thr Ala Leu Lys Tyr 
        675                 680                 685             


Met Val Ser Asn Pro Asn Glu Asn Ser Leu Asn Ser Asn Pro Val Cys 
    690                 695                 700                 


Asp Leu Asp Ser Thr Ser Ala Gly Gln Ile His Leu Ile Ser Asp Arg 
705                 710                 715                 720 


Glu Asn Gln Val Gly Arg Lys Asp Thr Asn Lys Gln Ser Ser Ile Lys 
                725                 730                 735     


Cys Val Glu Asp Val Ser Leu Cys Asn Pro Glu Arg Thr Asn Gly Thr 
            740                 745                 750         


Leu Asn Ser Ala Gln Glu Asp Lys Lys Ser Lys Val Pro Val Glu Gly 
        755                 760                 765             


Leu Thr Ile Pro Ser Lys Leu Ser Asp Glu Ser Ala Met Asp Glu Asp 
    770                 775                 780                 


Lys His Ala Thr Ala Asp Ser Asp Val Ser Ser Lys Cys Phe Ser Gly 
785                 790                 795                 800 


Gln Leu Ser Glu Lys Asn Ser Pro Lys Asn Met Glu Thr Ser Glu Ser 
                805                 810                 815     


Pro Glu Ser His Glu Thr Pro Glu Thr Pro Phe Val Gly His Trp Asn 
            820                 825                 830         


Leu Ser Thr Gly Val Leu His Gln Arg Glu Ser Pro Glu Ser Asp Thr 
        835                 840                 845             


Gly Ser Ala Thr Thr Ser Ser Asp Asp Ile Lys Pro Arg Ser Glu Asp 
    850                 855                 860                 


Tyr Asp Ala Gly Gly Ser Gln Asp Asp Asp Gly Ser Asn Asp Arg Gly 
865                 870                 875                 880 


Ile Ser Lys Cys Gly Thr Met Leu Cys His Asp Phe Leu Gly Arg Ser 
                885                 890                 895     


Ser Ser Asp Thr Ser Thr Pro Glu Glu Leu Lys Ile Tyr Asp Ser Asn 
            900                 905                 910         


Leu Arg Ile Glu Val Lys Met Lys Lys Gln Ser Asn Asn Asp Leu Phe 
        915                 920                 925             


Gln Val Asn Ser Thr Ser Asp Asp Glu Ile Pro Arg Lys Arg Pro Glu 
    930                 935                 940                 


Ile Trp Ser Arg Ser Ala Ile Val His Ser Arg Glu Arg Glu Asn Ile 
945                 950                 955                 960 


Pro Arg Gly Ser Val Gln Phe Ala Gln Glu Ile Asp Gln Val Ser Ser 
                965                 970                 975     


Ser Ala Asp Glu Thr Glu Asp Glu Arg Ser Glu Ala Glu Asn Val Ala 
            980                 985                 990         


Glu Asn Phe Ser Ile Ser Asn Pro  Ala Pro Gln Gln Phe  Gln Gly Ile 
        995                 1000                 1005             


Ile Asn  Leu Ala Phe Glu Asp  Ala Thr Glu Asn Glu  Cys Arg Glu 
    1010                 1015                 1020             


Phe Ser  Ala Thr Lys Lys Phe  Lys Arg Ser Val Leu  Leu Ser Val 
    1025                 1030                 1035             


Asp Glu  Cys Glu Glu Leu Gly  Ser Asp Glu Gly Glu  Val His Thr 
    1040                 1045                 1050             


Pro Phe  Gln Ala Ser Val Asp  Ser Phe Ser Pro Ser  Asp Val Phe 
    1055                 1060                 1065             


Asp Gly  Ile Ser His Glu His  His Gly Arg Thr Cys  Tyr Ser Arg 
    1070                 1075                 1080             


Phe Ser  Arg Glu Ser Glu Asp  Asn Ile Leu Glu Cys  Lys Gln Asn 
    1085                 1090                 1095             


Lys Gly  Asn Ser Val Cys Lys  Asn Glu Ser Thr Val  Leu Asp Leu 
    1100                 1105                 1110             


Ser Ser  Ile Asp Ser Ser Arg  Lys Asn Lys Gln Ser  Val Ser Ala 
    1115                 1120                 1125             


Thr Glu  Lys Lys Asn Thr Ile  Asp Val Leu Ser Ser  Arg Ser Arg 
    1130                 1135                 1140             


Gln Leu  Leu Arg Glu Asp Lys  Lys Val Asn Asn Gly  Ser Asn Val 
    1145                 1150                 1155             


Glu Asn  Asp Ile Gln Gln Arg  Ser Lys Phe Leu Asp  Ser Asp Val 
    1160                 1165                 1170             


Lys Ser  Gln Glu Arg Pro Cys  His Leu Asp Leu His  Gln Arg Glu 
    1175                 1180                 1185             


Pro Asn  Ser Asp Ile Pro Lys  Asn Ser Ser Thr Lys  Ser Leu Asp 
    1190                 1195                 1200             


Ser Phe  Arg Ser Gln Val Leu  Pro Gln Glu Gly Pro  Val Lys Glu 
    1205                 1210                 1215             


Ser His  Ser Thr Thr Thr Glu  Lys Ala Asn Ile Ala  Leu Ser Ala 
    1220                 1225                 1230             


Gly Asp  Ile Asp Asp Cys Asp  Thr Leu Ala Gln Thr  Arg Met Tyr 
    1235                 1240                 1245             


Asp His  Arg Pro Ser Lys Thr  Leu Ser Pro Ile Tyr  Glu Met Asp 
    1250                 1255                 1260             


Val Ile  Glu Ala Phe Glu Gln  Lys Val Glu Ser Glu  Thr His Val 
    1265                 1270                 1275             


Thr Asp  Met Asp Phe Glu Asp  Asp Gln His Phe Ala  Lys Gln Asp 
    1280                 1285                 1290             


Trp Thr  Leu Leu Lys Gln Leu  Leu Ser Glu Gln Asp  Ser Asn Leu 
    1295                 1300                 1305             


Asp Val  Thr Asn Ser Val Pro  Glu Asp Leu Ser Leu  Ala Gln Tyr 
    1310                 1315                 1320             


Leu Ile  Asn Gln Thr Leu Leu  Leu Ala Arg Asp Ser  Ser Lys Pro 
    1325                 1330                 1335             


Gln Gly  Ile Thr His Ile Asp  Thr Leu Asn Arg Trp  Ser Glu Leu 
    1340                 1345                 1350             


Thr Ser  Pro Leu Asp Ser Ser  Ala Ser Ile Thr Met  Ala Ser Phe 
    1355                 1360                 1365             


Ser Ser  Glu Asp Cys Ser Pro  Gln Gly Glu Trp Thr  Ile Leu Glu 
    1370                 1375                 1380             


Leu Glu  Thr Gln His 
    1385             


<210>  6553
<211>  1315
<212>  DNA
<213>  Homosapiens

<400>  6553
tcctgcctca gcctctcaaa gtggtgggat aacaaaagtt ttttttttgc tttttaaaaa     60

attcaatgtt agcaagagaa tgataagttt gggagcttca tatgatgctt tagaagtgta    120

aatttccttt ctgataagca gctaagcaag ctatatcagg aatgtagctt tttggttgtt    180

ttttgagatg gtcttgcgtt gttgcccagg ctttgagtgc agtggcatga tcatggctca    240

ctgcagcctc aacctccctg actcaagcga tcctcccacc tcagcctccc aggtagctgc    300

gactacaggc acgcaccact ccactcggct aattttttat tttttatttt tgtagagaca    360

gggtcttcct atgttgccca ggccagtctc tgaactcctg ggctcaagtg atccttctgc    420

atggtggctc acacctataa tcccagcctc ccaagtagct gggactacaa ggcacctact    480

gctgcactta gctttatctt ttaactcata ttttaaatgt cttctacaag gcacagaaaa    540

ataagtagtt gtgttcattt ttaagtaaat agtagtaaac agtttcaaat gctgtttgag    600

atgttaatta aggcacacac ttagactagt ccatttgatt tgaaaattag gattttattt    660

gtgctttttg ttaattactg gcttttaaaa gatcagtagt ggggcagaaa ctagactagt    720

gggttgaagg gtgaatagga aataagtaat acttattctt tcaaggagct tgactgaaaa    780

ggagacagtg gtagtttgaa gatattgctg tttttaagat aaaaatgatt tcagcacttt    840

aaaaataaaa agttggaaat gatcaatgaa tcaaggatca tcaagaaaga ggcaagagga    900

agtaagatta agcacaaaga gtatcaactg ataggtggca tttcaaggaa cttcaggtgt    960

tgaatatcta aagcaccaaa tgcgtgtgga cagcagtgaa gataaagctg gaaatgcgcc   1020

ggcagaccaa cacatgatga gccctgtagg tggtggacaa agactatgag caagccattt   1080

aggcaaacat ctgaagaatt taaaaatcaa aggcaaacaa ataggactgt ttcattaaga   1140

tcacttgcat tctaacaggt tatgatgaat ggaaagctga tggttcctgg ttggaaaaaa   1200

gataattttc aatttggaca tgtcacattt gagatgcagt tgacacaccc aagatacata   1260

atatattgtc tttcaaaatt cagaaaccta ataaaccatg atcttaataa ccgcc        1315


<210>  6554
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  6554

Met Leu Pro Arg Pro Val Ser Glu Leu Leu Gly Ser Ser Asp Pro Ser 
1               5                   10                  15      


Ala Trp Trp Leu Thr Pro Ile Ile Pro Ala Ser Gln Val Ala Gly Thr 
            20                  25                  30          


Thr Arg His Leu Leu Leu His Leu Ala Leu Ser Phe Asn Ser Tyr Phe 
        35                  40                  45              


Lys Cys Leu Leu Gln Gly Thr Glu Lys 
    50                  55          


<210>  6555
<211>  830
<212>  DNA
<213>  Homosapiens

<400>  6555
gccccaggca ccctgggcgc tctgccctac cggcggcgcc tctcactgct cacggaacgt     60

tctggaagtt tgggaaaccc tgagcggtct ctgaggacct ggtgagcaga ttgttgcacc    120

attagaagct aggttgatcc acagacagat ggctgaaagt ggaaaagaaa aaataaaatg    180

gacaaccacc attattatta gctcatctct taagagttat gaagttgcaa ctgccctaga    240

aaatcgaagc cacaaagttc gatattcaga ttcagtggaa aatggatcaa ttatattttc    300

tctttctgga gttgcatttt tattaatgga tactaaggaa tgtcttctgt caactgaaga    360

aatatttcta gccaaaattg agaaatttat taacattcac caaaatagtt ttttggtttt    420

gtctgctgcc ctccatgggc ctgaagaatg gaaactgatg ttcaggattc agcagagatt    480

cctgggttgt aacttacgaa tacttccagt acacaacaca gtaaatgcta ttaatcttat    540

gtgcactata gcaaagacta cctccaaacc atacatagat agcatttgct acagaatgat    600

aacagctaaa gcttacatca ttgagcaaag tcctgtttgg aaaacacttc agaagataaa    660

actgaatagt gattcagtta acccaaatta gagtaccaac ttaatgtttt tctcgaagaa    720

tgtgaaaata attagacctg ttaaattata atattcaaat atctatttaa agacatttat    780

attaatttga aataataaca tatacaatta aaagtgattt tattttagga               830


<210>  6556
<211>  180
<212>  PRT
<213>  Homosapiens

<400>  6556

Met Ala Glu Ser Gly Lys Glu Lys Ile Lys Trp Thr Thr Thr Ile Ile 
1               5                   10                  15      


Ile Ser Ser Ser Leu Lys Ser Tyr Glu Val Ala Thr Ala Leu Glu Asn 
            20                  25                  30          


Arg Ser His Lys Val Arg Tyr Ser Asp Ser Val Glu Asn Gly Ser Ile 
        35                  40                  45              


Ile Phe Ser Leu Ser Gly Val Ala Phe Leu Leu Met Asp Thr Lys Glu 
    50                  55                  60                  


Cys Leu Leu Ser Thr Glu Glu Ile Phe Leu Ala Lys Ile Glu Lys Phe 
65                  70                  75                  80  


Ile Asn Ile His Gln Asn Ser Phe Leu Val Leu Ser Ala Ala Leu His 
                85                  90                  95      


Gly Pro Glu Glu Trp Lys Leu Met Phe Arg Ile Gln Gln Arg Phe Leu 
            100                 105                 110         


Gly Cys Asn Leu Arg Ile Leu Pro Val His Asn Thr Val Asn Ala Ile 
        115                 120                 125             


Asn Leu Met Cys Thr Ile Ala Lys Thr Thr Ser Lys Pro Tyr Ile Asp 
    130                 135                 140                 


Ser Ile Cys Tyr Arg Met Ile Thr Ala Lys Ala Tyr Ile Ile Glu Gln 
145                 150                 155                 160 


Ser Pro Val Trp Lys Thr Leu Gln Lys Ile Lys Leu Asn Ser Asp Ser 
                165                 170                 175     


Val Asn Pro Asn 
            180 


<210>  6557
<211>  428
<212>  DNA
<213>  Homosapiens

<400>  6557
gaaaccctga gcggtctctg aggacctggt gagcagattg ttgcaccatt agaagctagg     60

ttgatccaca gacagatggc tgaaagtgga aaagaaaaaa taaaatggac aaccaccatt    120

attattagct catctcttaa gattcctggg ttgtaactta cgaatacttc cagtacacaa    180

cacagtaaat gctattaatc ttatgtgcac tatagcaaag actacctcca aaccatacat    240

agatagcatt tgctacagaa tgataacagc taaagcttac atcattgagc aaagtcctgt    300

ttggaaaaca cttcagaaga taaaactgaa tagtgattca gttaacccaa attagagtac    360

caacttaatg tttttctcga agaatgtgaa aataattaga cctgttaaat tataatattc    420

aaatatct                                                             428


<210>  6558
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  6558

Met Cys Thr Ile Ala Lys Thr Thr Ser Lys Pro Tyr Ile Asp Ser Ile 
1               5                   10                  15      


Cys Tyr Arg Met Ile Thr Ala Lys Ala Tyr Ile Ile Glu Gln Ser Pro 
            20                  25                  30          


Val Trp Lys Thr Leu Gln Lys Ile Lys Leu Asn Ser Asp Ser Val Asn 
        35                  40                  45              


Pro Asn 
    50  


<210>  6559
<211>  459
<212>  DNA
<213>  Homosapiens

<400>  6559
atggtacaaa gaacagctac agctgatgac aaaaagctgg agaagagcta caagctgccc     60

gacggccagg tcatcaccat cggcaacgaa cggttccggt gtccggaggt gctgttccag    120

tcttccttcc tgggcatgga atcctgtggc acccacaaga ccaccttcaa ctgcatcatg    180

aagtgtgatg tggacatctt caaagacctg tacgccaaca cagtgctgtc cagcggcacc    240

accatgtacc cagacatcac caacaggatg cagaaggcaa tcactgccct ggcacctagc    300

accatgaaga tcaagatcat tgcaccccga gagcgaaagt actcggtgtg gatcggcggc    360

tccatcctga cctcactgtc caccttccag cagatgtgca ctagcaagca ggagtatgac    420

aagttgggcc cctccactgt tcaccacaaa tgcttctaa                           459


<210>  6560
<211>  152
<212>  PRT
<213>  Homosapiens

<400>  6560

Met Val Gln Arg Thr Ala Thr Ala Asp Asp Lys Lys Leu Glu Lys Ser 
1               5                   10                  15      


Tyr Lys Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe 
            20                  25                  30          


Arg Cys Pro Glu Val Leu Phe Gln Ser Ser Phe Leu Gly Met Glu Ser 
        35                  40                  45              


Cys Gly Thr His Lys Thr Thr Phe Asn Cys Ile Met Lys Cys Asp Val 
    50                  55                  60                  


Asp Ile Phe Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Ser Gly Thr 
65                  70                  75                  80  


Thr Met Tyr Pro Asp Ile Thr Asn Arg Met Gln Lys Ala Ile Thr Ala 
                85                  90                  95      


Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Arg Glu Arg 
            100                 105                 110         


Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Thr Ser Leu Ser Thr 
        115                 120                 125             


Phe Gln Gln Met Cys Thr Ser Lys Gln Glu Tyr Asp Lys Leu Gly Pro 
    130                 135                 140                 


Ser Thr Val His His Lys Cys Phe 
145                 150         


<210>  6561
<211>  955
<212>  DNA
<213>  Homosapiens

<400>  6561
cagattgttg caccattaga agctaggttg atccacagac agatggctga aagtggaaaa     60

gaaaaaataa aatggacaac caccattatt attagctcat ctcttaagta gaaagaaggt    120

ctcgctacat tgcccaggct gttctcaaac tcctgggctg aagtgattct ctcacctcag    180

cctcccaaag tgctaggatt acaggtgtga gccattgtgc ctggccaagt ttaaatttta    240

acctatcagg aaaaactatt aaccacctag attttagtat tgtgggtaat atgatttaat    300

tgcctgggtg gaataggaaa tcaggtgata tttgaaatga gttatgaagt tgcaactgcc    360

ctagaaaatc gaagccacaa agttcgatat tcagattcag tggaaaatgg atcaattata    420

ttttctcttt ctggagttgc atttttatta atggatacta aggaatgtct tctgtcaact    480

gaagaaatat ttctagccaa aattgagaaa tttattaaca ttcaccaaaa tagttttttg    540

gttttgtctg ctgccctcca tgggcctgaa gaatggaaac tgatgttcag gattcagcag    600

agattcctgg gttgtaactt acgaatactt ccagtacaca acacagtaaa tgctattaat    660

cttatgtgca ctatagcaaa gactacctcc aaaccataca tagatagcat ttgctacaga    720

atgataacag ctaaagctta catcattgag caaagtcctg tttggaaaac acttcagaag    780

ataaaactga atagtgattc agttaaccca aattagagta ccaacttaat gtttttctcg    840

aagaatgtga aaataattag acctgttaaa ttataatatt caaatatcta tttaaagaca    900

tttatattaa tttgaaataa taacatatac aattaaaagt gattttattt tagga         955


<210>  6562
<211>  159
<212>  PRT
<213>  Homosapiens

<400>  6562

Met Ser Tyr Glu Val Ala Thr Ala Leu Glu Asn Arg Ser His Lys Val 
1               5                   10                  15      


Arg Tyr Ser Asp Ser Val Glu Asn Gly Ser Ile Ile Phe Ser Leu Ser 
            20                  25                  30          


Gly Val Ala Phe Leu Leu Met Asp Thr Lys Glu Cys Leu Leu Ser Thr 
        35                  40                  45              


Glu Glu Ile Phe Leu Ala Lys Ile Glu Lys Phe Ile Asn Ile His Gln 
    50                  55                  60                  


Asn Ser Phe Leu Val Leu Ser Ala Ala Leu His Gly Pro Glu Glu Trp 
65                  70                  75                  80  


Lys Leu Met Phe Arg Ile Gln Gln Arg Phe Leu Gly Cys Asn Leu Arg 
                85                  90                  95      


Ile Leu Pro Val His Asn Thr Val Asn Ala Ile Asn Leu Met Cys Thr 
            100                 105                 110         


Ile Ala Lys Thr Thr Ser Lys Pro Tyr Ile Asp Ser Ile Cys Tyr Arg 
        115                 120                 125             


Met Ile Thr Ala Lys Ala Tyr Ile Ile Glu Gln Ser Pro Val Trp Lys 
    130                 135                 140                 


Thr Leu Gln Lys Ile Lys Leu Asn Ser Asp Ser Val Asn Pro Asn 
145                 150                 155                 


<210>  6563
<211>  1467
<212>  DNA
<213>  Homosapiens

<400>  6563
gggaaagcat cctctagaac tagatccgtg gtgtggatat caattgaaag gccatacttg     60

ggatgaaggc ataaataagg tagagtcatt gtggagatgg ctcatagagg aagagacgtc    120

tgtgaattta tcctcaaata attttctcat aaataaaact taacaagtta atagatctca    180

aaacctggag ctatccaaat ggtgcagtga taagcgtagt gccccaagta catttttctt    240

ttaattggta ttcacataac tagctatagt aataattatt aaatagtgaa gtccattgtg    300

aaaagcaagg gccatgtttc atttattttt gttttttgag cttttatcgc gtttaatagt    360

aggcaatcaa tcattgttga actaaataac tcattctttc attcttaaca gactggatta    420

tggacagaac ttggaaatat tgagaataat ttcttaaagc cacttcatat aggacttaat    480

atgtcaaaag cacattatga agcagaaatt aaaaatagcc aagaggccca gaaatctaaa    540

gatctttgtt ctataactgt aagtggagaa gagatcccta atatgcctcc tgaaatgcag    600

cttaaggtcc tgcattcagc tcttttcaca tttgatttga ttgaaagtgt tctagctcga    660

gtggaagaac tcattgaaat aaaaacaaag tctacctctg aagaaaatat tgggataaag    720

tgaaagttcc atttcctaaa taaaaactaa taaaatatag tactttccat tatgattcat    780

ttaatacctt tataaaaaat ttttctgtaa aaatttactg cttgaaaaat aaatgtagct    840

tttctcattt atcaatttct ataatgatac actatagaac aggttttttt ggttttaaag    900

ttatctaatg gtaaataatg cccacatatg tcctaaatac tacttttgaa aatccaatac    960

aaactaataa ttttataact tcataaaatg tagctgaatt gtctatattc attcctacag   1020

ttttagtgag cttataaaaa tactgataca ctttctgctg cagttagatg ctatgtaaca   1080

tttcggaact cctagtgtca agttggctat cataccagtg taaagaggcc agttgacttt   1140

tcttagcttc tcttttcctg gctcaggtgg agtctttggg agcagagtcc catcaccacc   1200

tctccagcag aagttataat aggaaaacat ctgcaaagat taattttaga aatacttgct   1260

acctttatgg aaaaaaacta aaaaatatat atgactttaa gaaactgatt agaaaattct   1320

gtatttttat ttcctactaa agatttgtcc atttaactca ctaagaagct acacctgagt   1380

tttatggtat atgtatgtat cagtcctttg ctaaagagcg ttaaatcttg cagcgaaact   1440

cctaaaataa aatcactttt aattgta                                       1467


<210>  6564
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  6564

Met Ser Lys Ala His Tyr Glu Ala Glu Ile Lys Asn Ser Gln Glu Ala 
1               5                   10                  15      


Gln Lys Ser Lys Asp Leu Cys Ser Ile Thr Val Ser Gly Glu Glu Ile 
            20                  25                  30          


Pro Asn Met Pro Pro Glu Met Gln Leu Lys Val Leu His Ser Ala Leu 
        35                  40                  45              


Phe Thr Phe Asp Leu Ile Glu Ser Val Leu Ala Arg Val Glu Glu Leu 
    50                  55                  60                  


Ile Glu Ile Lys Thr Lys Ser Thr Ser Glu Glu Asn Ile Gly Ile Lys 
65                  70                  75                  80  


<210>  6565
<211>  1235
<212>  DNA
<213>  Homosapiens

<400>  6565
atttactgaa ttatcttggc aactttatca aaaatcattt tataagtatg ggtctatttt     60

tggactctat tccatttacc tgtatctatt cttttaccaa taccacactg tcttgattcc    120

tttataggaa gaaattattc tgttttattc ctttatagga agtcttgacc tcaagtaata    180

ctggattatg gacagaactt ggaaatattg agaataattt cttaaagcca cttcatatag    240

gacttaatat gtcaaaagca cattatgaag cagaaattaa aaatagccaa gaggcccaga    300

aatctaaaga tctttgttct ataactgtaa gtggagaaga gatccctaat atgcctcctg    360

aaatgcagct taaggtcctg cattcagctc ttttcacatt tgatttgatt gaaagtgttc    420

tagctcgagt ggaagaactc attgaaataa aaacaaagtc tacctctgaa gaaaatattg    480

ggataaagtg aaagttccat ttcctaaata aaaactaata aaatatagta ctttccatta    540

tgattcattt aataccttta taaaaaattt ttctgtaaaa atttactgct tgaaaaataa    600

atgtagcttt tctcatttat caatttctat aatgatacac tatagaacag gtttttttgg    660

ttttaaagtt atctaatggt aaataatgcc cacatatgtc ctaaatacta cttttgaaaa    720

tccaatacaa actaataatt ttataacttc ataaaatgta gctgaattgt ctatattcat    780

tcctacagtt ttagtgagct tataaaaata ctgatacact ttctgctgca gttagatgct    840

atgtaacatt tcggaactcc tagtgtcaag ttggctatca taccagtgta aagaggccag    900

ttgacttttc ttagcttctc ttttcctggc tcaggtggag tctttgggag cagagtccca    960

tcaccacctc tccagcagaa gttataatag gaaaacatct gcaaagatta attttagaaa   1020

tacttgctac ctttatggaa aaaaactaaa aaatatatat gactttaaga aactgattag   1080

aaaattctgt atttttattt cctactaaag atttgtccat ttaactcact aagaagctac   1140

acctgagttt tatggtatat gtatgtatca gtcctttgct aaagagcgtt aaatcttgca   1200

gcgaaactcc taaaataaaa tcacttttaa ttgta                              1235


<210>  6566
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  6566

Met Ser Lys Ala His Tyr Glu Ala Glu Ile Lys Asn Ser Gln Glu Ala 
1               5                   10                  15      


Gln Lys Ser Lys Asp Leu Cys Ser Ile Thr Val Ser Gly Glu Glu Ile 
            20                  25                  30          


Pro Asn Met Pro Pro Glu Met Gln Leu Lys Val Leu His Ser Ala Leu 
        35                  40                  45              


Phe Thr Phe Asp Leu Ile Glu Ser Val Leu Ala Arg Val Glu Glu Leu 
    50                  55                  60                  


Ile Glu Ile Lys Thr Lys Ser Thr Ser Glu Glu Asn Ile Gly Ile Lys 
65                  70                  75                  80  


<210>  6567
<211>  2629
<212>  DNA
<213>  Homosapiens

<400>  6567
cggggccaga agagcgggct aagacgccgg aggaggtggc ggcggctggg agaggcgagg     60

gttctggccg attttagcat cgaaactagg agaaataaga atggctgtag aggaacttca    120

gtctataata aagagatgtc aaatcctaga agagcaagac tttaaagaag aggattttgg    180

cctatttcag ttagctgggc aaagatgcat agaagaaggg cacacagacc agctattaga    240

aattattcaa aatgaaaaga ataaggtcat catcaagaat atgggctgga atctcgttgg    300

tcctgttgtt cgatgccttt tgtgtaaaga taaagaggat agtaaaagaa aagtttattt    360

tttgatcttt gatttattgg taaagttatg caatccaaag gaattattgt tgggtttgct    420

tgaactgatt gaagagccct ctggaaaaca gatatcccaa agtattcttc ttttgcttca    480

gccattacaa acagtgattc agaaacttca taacaaggca tattcaattg gattagcatt    540

gtctaccctt tggaatcagc tatctcttct tcctgttcca tactcaaaag aacaaataca    600

aatggatgac tatggccttt gtcagtgttg caaggcctta atagagttca ctaagccttt    660

tgtggaagaa gtcattgata acaaagaaaa ctcactggaa aatgaaaagt taaaggatga    720

attactgaaa ttttgtttca aaagcttgaa atgccctttg ctgacagcac aattctttga    780

acagtctgaa gaaggtggaa atgatccttt caggtatttt gcatcagaaa taataggttt    840

tttatcagca attggacacc ctttccccaa aatgattttt aatcatggaa ggaaaaagag    900

aacttggaat taccttgaat ttgaagaaga agaaaataaa cagttagcag actcaatggc    960

ttctctggca tatctagtat ttgtacaggg catccatatt gatcagcttc caatggtctt   1020

aagcccattg taccttttgc agtttaatat ggggcacatt gaagtctttt tgcaaagaac   1080

agaagagtct gttatctcca aaggattgga gctgctggag aatagtttat tgagaataga   1140

agacaatagt ctactttacc agtacttaga aatcaagagt tttcttactg tacctcaggg   1200

cttagtgaaa gtaatgacac tttgccccat tgagacactg aggaaaaaga gtttagctat   1260

gcttcagctg tatattaaca agttggattc acaaggcaaa tatacattat ttaggtgctt   1320

attgaataca agtaatcact caggtgtgga ggcttttatt attcaaaata tcaaaaatca   1380

aattgacatg tcattaaaga gaacacgtaa caacaaatgg tttacaggac cacagttgat   1440

ttcccttctt gatttggtac tttttctccc agagggtgca gaaacagatt tactgcaaaa   1500

ctcagatagg attatggctt cattaaattt attgaggtat ttggttatca aagataatga   1560

aaatgacaat caaactggat tatggacaga acttggaaat attgagaata atttcttaaa   1620

gccacttcat ataggactta atatgtcaaa agcacattat gaagcagaaa ttaaaaatag   1680

ccaagaggcc cagaaatcta aagatctttg ttctataact gtaagtggag aagagatccc   1740

taatatgcct cctgaaatgc agcttaaggt cctgcattca gctcttttca catttgattt   1800

gattgaaagt gttctagctc gagtggaaga actcattgaa ataaaaacaa agtctacctc   1860

tgaagaaaat attgggataa agtgaaagtt ccatttccta aataaaaact aataaaatat   1920

agtactttcc attatgattc atttaatacc tttataaaaa atttttctgt aaaaatttac   1980

tgcttgaaaa ataaatgtag cttttctcat ttatcaattt ctataatgat acactataga   2040

acaggttttt ttggttttaa agttatctaa tggtaaataa tgcccacata tgtcctaaat   2100

actacttttg aaaatccaat acaaactaat aattttataa cttcataaaa tgtagctgaa   2160

ttgtctatat tcattcctac agttttagtg agcttataaa aatactgata cactttctgc   2220

tgcagttaga tgctatgtaa catttcggaa ctcctagtgt caagttggct atcataccag   2280

tgtaaagagg ccagttgact tttcttagct tctcttttcc tggctcaggt ggagtctttg   2340

ggagcagagt cccatcacca cctctccagc agaagttata ataggaaaac atctgcaaag   2400

attaatttta gaaatacttg ctacctttat ggaaaaaaac taaaaaatat atatgacttt   2460

aagaaactga ttagaaaatt ctgtattttt atttcctact aaagatttgt ccatttaact   2520

cactaagaag ctacacctga gttttatggt atatgtatgt atcagtcctt tgctaaagag   2580

cgttaaatct tgcagcgaaa ctcctaaaat aaaatcactt ttaattgta               2629


<210>  6568
<211>  594
<212>  PRT
<213>  Homosapiens

<400>  6568

Met Ala Val Glu Glu Leu Gln Ser Ile Ile Lys Arg Cys Gln Ile Leu 
1               5                   10                  15      


Glu Glu Gln Asp Phe Lys Glu Glu Asp Phe Gly Leu Phe Gln Leu Ala 
            20                  25                  30          


Gly Gln Arg Cys Ile Glu Glu Gly His Thr Asp Gln Leu Leu Glu Ile 
        35                  40                  45              


Ile Gln Asn Glu Lys Asn Lys Val Ile Ile Lys Asn Met Gly Trp Asn 
    50                  55                  60                  


Leu Val Gly Pro Val Val Arg Cys Leu Leu Cys Lys Asp Lys Glu Asp 
65                  70                  75                  80  


Ser Lys Arg Lys Val Tyr Phe Leu Ile Phe Asp Leu Leu Val Lys Leu 
                85                  90                  95      


Cys Asn Pro Lys Glu Leu Leu Leu Gly Leu Leu Glu Leu Ile Glu Glu 
            100                 105                 110         


Pro Ser Gly Lys Gln Ile Ser Gln Ser Ile Leu Leu Leu Leu Gln Pro 
        115                 120                 125             


Leu Gln Thr Val Ile Gln Lys Leu His Asn Lys Ala Tyr Ser Ile Gly 
    130                 135                 140                 


Leu Ala Leu Ser Thr Leu Trp Asn Gln Leu Ser Leu Leu Pro Val Pro 
145                 150                 155                 160 


Tyr Ser Lys Glu Gln Ile Gln Met Asp Asp Tyr Gly Leu Cys Gln Cys 
                165                 170                 175     


Cys Lys Ala Leu Ile Glu Phe Thr Lys Pro Phe Val Glu Glu Val Ile 
            180                 185                 190         


Asp Asn Lys Glu Asn Ser Leu Glu Asn Glu Lys Leu Lys Asp Glu Leu 
        195                 200                 205             


Leu Lys Phe Cys Phe Lys Ser Leu Lys Cys Pro Leu Leu Thr Ala Gln 
    210                 215                 220                 


Phe Phe Glu Gln Ser Glu Glu Gly Gly Asn Asp Pro Phe Arg Tyr Phe 
225                 230                 235                 240 


Ala Ser Glu Ile Ile Gly Phe Leu Ser Ala Ile Gly His Pro Phe Pro 
                245                 250                 255     


Lys Met Ile Phe Asn His Gly Arg Lys Lys Arg Thr Trp Asn Tyr Leu 
            260                 265                 270         


Glu Phe Glu Glu Glu Glu Asn Lys Gln Leu Ala Asp Ser Met Ala Ser 
        275                 280                 285             


Leu Ala Tyr Leu Val Phe Val Gln Gly Ile His Ile Asp Gln Leu Pro 
    290                 295                 300                 


Met Val Leu Ser Pro Leu Tyr Leu Leu Gln Phe Asn Met Gly His Ile 
305                 310                 315                 320 


Glu Val Phe Leu Gln Arg Thr Glu Glu Ser Val Ile Ser Lys Gly Leu 
                325                 330                 335     


Glu Leu Leu Glu Asn Ser Leu Leu Arg Ile Glu Asp Asn Ser Leu Leu 
            340                 345                 350         


Tyr Gln Tyr Leu Glu Ile Lys Ser Phe Leu Thr Val Pro Gln Gly Leu 
        355                 360                 365             


Val Lys Val Met Thr Leu Cys Pro Ile Glu Thr Leu Arg Lys Lys Ser 
    370                 375                 380                 


Leu Ala Met Leu Gln Leu Tyr Ile Asn Lys Leu Asp Ser Gln Gly Lys 
385                 390                 395                 400 


Tyr Thr Leu Phe Arg Cys Leu Leu Asn Thr Ser Asn His Ser Gly Val 
                405                 410                 415     


Glu Ala Phe Ile Ile Gln Asn Ile Lys Asn Gln Ile Asp Met Ser Leu 
            420                 425                 430         


Lys Arg Thr Arg Asn Asn Lys Trp Phe Thr Gly Pro Gln Leu Ile Ser 
        435                 440                 445             


Leu Leu Asp Leu Val Leu Phe Leu Pro Glu Gly Ala Glu Thr Asp Leu 
    450                 455                 460                 


Leu Gln Asn Ser Asp Arg Ile Met Ala Ser Leu Asn Leu Leu Arg Tyr 
465                 470                 475                 480 


Leu Val Ile Lys Asp Asn Glu Asn Asp Asn Gln Thr Gly Leu Trp Thr 
                485                 490                 495     


Glu Leu Gly Asn Ile Glu Asn Asn Phe Leu Lys Pro Leu His Ile Gly 
            500                 505                 510         


Leu Asn Met Ser Lys Ala His Tyr Glu Ala Glu Ile Lys Asn Ser Gln 
        515                 520                 525             


Glu Ala Gln Lys Ser Lys Asp Leu Cys Ser Ile Thr Val Ser Gly Glu 
    530                 535                 540                 


Glu Ile Pro Asn Met Pro Pro Glu Met Gln Leu Lys Val Leu His Ser 
545                 550                 555                 560 


Ala Leu Phe Thr Phe Asp Leu Ile Glu Ser Val Leu Ala Arg Val Glu 
                565                 570                 575     


Glu Leu Ile Glu Ile Lys Thr Lys Ser Thr Ser Glu Glu Asn Ile Gly 
            580                 585                 590         


Ile Lys 
        


<210>  6569
<211>  2544
<212>  DNA
<213>  Homosapiens

<400>  6569
cggggccaga agagcgggct aagacgccgg aggaggtggc ggcggctggg agaggcgagg     60

gttctggccg attttagcat cgaaactagg agaaataaga atggctgtag aggaacttca    120

gtctataata aagagatgtc aaatcctaga agagcaagac tttaaagaag aggattttgg    180

cctatttcag ttagctgggc aaagatgcat agaagaaggg cacacagacc agctattaga    240

aattattcaa aatgaaaaga ataaggtcat catcaagaat atgggctgga atctcgttgg    300

tcctgttgtt cgatgccttt tgtgtaaaga taaagaggat agtaaaagaa aagtttattt    360

tttgatcttt gatttattgg taaagttatg caatccaaag gaattattgt tgggtttgct    420

tgaactgatt gaagagccct ctggaaaaca gatatcccaa agtattcttc ttttgcttca    480

gccattacaa acagtgattc agaaacttca taacaaggca tattcaattg gattagcatt    540

gtctaccctt tggaatcagc tatctcttct tcctgttcca tactcaaaag aacaaataca    600

aatggatgac tatggccttt gtcagtgttg caaggcctta atagagttca ctaagccttt    660

tgtggaagaa gtcattgata acaaagaaaa ctcactggaa aatgaaaagt taaaggatga    720

attactgaaa ttttgtttca aaagcttgaa atgccctttg ctgacagcac aattctttga    780

acagtctgaa gaaggtggaa atgatccttt caggtatttt gcatcagaaa taataggttt    840

tttatcagca attggacacc ctttccccaa aatgattttt aatcatggaa ggaaaaagag    900

aacttggaat taccttgaat ttgaagaaga agaaaataaa cagttagcag actcaatggc    960

ttctctggca tatctagtat ttgtacaggg catccatatt gatcagcttc caatggtctt   1020

aagcccattg taccttttgc agtttaatat ggggcacatt gaagtctttt tgcaaagaac   1080

agaagagtct gttatctcca aaggattgga gctgctggag aatagtttat tgagaataga   1140

agacaatagt ctactttacc agtacttaga aatcaagagt tttcttactg tacctcaggg   1200

cttagtgaaa gtaatgacac tttgccccat tgagacactg aggaaaaaga gtttagctat   1260

gcttcagctg tatattaaca agttggattc acaaggcaaa tatacattat ttagagaaca   1320

cgtaacaaca aatggtttac aggaccacag ttgatttccc ttcttgattt ggtacttttt   1380

ctcccagagg gtgcagaaac agatttactg caaaactcag ataggattat ggcttcatta   1440

aatttattga ggtatttggt tatcaaagat aatgaaaatg acaatcaaac tggattatgg   1500

acagaacttg gaaatattga gaataatttc ttaaagccac ttcatatagg acttaatatg   1560

tcaaaagcac attatgaagc agaaattaaa aatagccaag aggcccagaa atctaaagat   1620

ctttgttcta taactgtaag tggagaagag atccctaata tgcctcctga aatgcagctt   1680

aaggtcctgc attcagctct tttcacattt gatttgattg aaagtgttct agctcgagtg   1740

gaagaactca ttgaaataaa aacaaagtct acctctgaag aaaatattgg gataaagtga   1800

aagttccatt tcctaaataa aaactaataa aatatagtac tttccattat gattcattta   1860

atacctttat aaaaaatttt tctgtaaaaa tttactgctt gaaaaataaa tgtagctttt   1920

ctcatttatc aatttctata atgatacact atagaacagg tttttttggt tttaaagtta   1980

tctaatggta aataatgccc acatatgtcc taaatactac ttttgaaaat ccaatacaaa   2040

ctaataattt tataacttca taaaatgtag ctgaattgtc tatattcatt cctacagttt   2100

tagtgagctt ataaaaatac tgatacactt tctgctgcag ttagatgcta tgtaacattt   2160

cggaactcct agtgtcaagt tggctatcat accagtgtaa agaggccagt tgacttttct   2220

tagcttctct tttcctggct caggtggagt ctttgggagc agagtcccat caccacctct   2280

ccagcagaag ttataatagg aaaacatctg caaagattaa ttttagaaat acttgctacc   2340

tttatggaaa aaaactaaaa aatatatatg actttaagaa actgattaga aaattctgta   2400

tttttatttc ctactaaaga tttgtccatt taactcacta agaagctaca cctgagtttt   2460

atggtatatg tatgtatcag tcctttgcta aagagcgtta aatcttgcag cgaaactcct   2520

aaaataaaat cacttttaat tgta                                          2544


<210>  6570
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  6570

Met Ala Val Glu Glu Leu Gln Ser Ile Ile Lys Arg Cys Gln Ile Leu 
1               5                   10                  15      


Glu Glu Gln Asp Phe Lys Glu Glu Asp Phe Gly Leu Phe Gln Leu Ala 
            20                  25                  30          


Gly Gln Arg Cys Ile Glu Glu Gly His Thr Asp Gln Leu Leu Glu Ile 
        35                  40                  45              


Ile Gln Asn Glu Lys Asn Lys Val Ile Ile Lys Asn Met Gly Trp Asn 
    50                  55                  60                  


Leu Val Gly Pro Val Val Arg Cys Leu Leu Cys Lys Asp Lys Glu Asp 
65                  70                  75                  80  


Ser Lys Arg Lys Val Tyr Phe Leu Ile Phe Asp Leu Leu Val Lys Leu 
                85                  90                  95      


Cys Asn Pro Lys Glu Leu Leu Leu Gly Leu Leu Glu Leu Ile Glu Glu 
            100                 105                 110         


Pro Ser Gly Lys Gln Ile Ser Gln Ser Ile Leu Leu Leu Leu Gln Pro 
        115                 120                 125             


Leu Gln Thr Val Ile Gln Lys Leu His Asn Lys Ala Tyr Ser Ile Gly 
    130                 135                 140                 


Leu Ala Leu Ser Thr Leu Trp Asn Gln Leu Ser Leu Leu Pro Val Pro 
145                 150                 155                 160 


Tyr Ser Lys Glu Gln Ile Gln Met Asp Asp Tyr Gly Leu Cys Gln Cys 
                165                 170                 175     


Cys Lys Ala Leu Ile Glu Phe Thr Lys Pro Phe Val Glu Glu Val Ile 
            180                 185                 190         


Asp Asn Lys Glu Asn Ser Leu Glu Asn Glu Lys Leu Lys Asp Glu Leu 
        195                 200                 205             


Leu Lys Phe Cys Phe Lys Ser Leu Lys Cys Pro Leu Leu Thr Ala Gln 
    210                 215                 220                 


Phe Phe Glu Gln Ser Glu Glu Gly Gly Asn Asp Pro Phe Arg Tyr Phe 
225                 230                 235                 240 


Ala Ser Glu Ile Ile Gly Phe Leu Ser Ala Ile Gly His Pro Phe Pro 
                245                 250                 255     


Lys Met Ile Phe Asn His Gly Arg Lys Lys Arg Thr Trp Asn Tyr Leu 
            260                 265                 270         


Glu Phe Glu Glu Glu Glu Asn Lys Gln Leu Ala Asp Ser Met Ala Ser 
        275                 280                 285             


Leu Ala Tyr Leu Val Phe Val Gln Gly Ile His Ile Asp Gln Leu Pro 
    290                 295                 300                 


Met Val Leu Ser Pro Leu Tyr Leu Leu Gln Phe Asn Met Gly His Ile 
305                 310                 315                 320 


Glu Val Phe Leu Gln Arg Thr Glu Glu Ser Val Ile Ser Lys Gly Leu 
                325                 330                 335     


Glu Leu Leu Glu Asn Ser Leu Leu Arg Ile Glu Asp Asn Ser Leu Leu 
            340                 345                 350         


Tyr Gln Tyr Leu Glu Ile Lys Ser Phe Leu Thr Val Pro Gln Gly Leu 
        355                 360                 365             


Val Lys Val Met Thr Leu Cys Pro Ile Glu Thr Leu Arg Lys Lys Ser 
    370                 375                 380                 


Leu Ala Met Leu Gln Leu Tyr Ile Asn Lys Leu Asp Ser Gln Gly Lys 
385                 390                 395                 400 


Tyr Thr Leu Phe Arg Glu His Val Thr Thr Asn Gly Leu Gln Asp His 
                405                 410                 415     


Ser 
    


<210>  6571
<211>  621
<212>  DNA
<213>  Homosapiens

<400>  6571
atttactgaa ttatcttggc aactttatca aaaatcattt tataagtatg ggtctatttt     60

tggactctat tccatttacc tgtatctatt cttttaccaa taccacactg tcttgattcc    120

tttataggaa gaaattattc tgttttattc ctttatagga agtcttgacc tcaagtaata    180

ctggattatg gacagaactt ggaaatattg agaataattt cttaaagcca cttcatatag    240

gacttaatat gtcaaaagca cattatgaag cagaaattaa aaatagccaa gaggcccaga    300

aatctaaaga tctttgttct ataactgtaa gtggagaaga gatccctaat atgcctcctg    360

aaatgcagct taaggtcctg cattcagctc ttttcacatt tgatttgatt gaaagtgttc    420

tagctcgagt ggaagaactc attgaaataa aaacaaagtc tacctctgaa gaaaatattg    480

ggataaagtg aaagttccat ttcctaaata aaaactaata aaatatagta ctttccatta    540

tgattcattt aataccttta taaaaaattt ttctgtaaaa atttactgct tgaaaaataa    600

atgtagcttt tctcatttat c                                              621


<210>  6572
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  6572

Met Ser Lys Ala His Tyr Glu Ala Glu Ile Lys Asn Ser Gln Glu Ala 
1               5                   10                  15      


Gln Lys Ser Lys Asp Leu Cys Ser Ile Thr Val Ser Gly Glu Glu Ile 
            20                  25                  30          


Pro Asn Met Pro Pro Glu Met Gln Leu Lys Val Leu His Ser Ala Leu 
        35                  40                  45              


Phe Thr Phe Asp Leu Ile Glu Ser Val Leu Ala Arg Val Glu Glu Leu 
    50                  55                  60                  


Ile Glu Ile Lys Thr Lys Ser Thr Ser Glu Glu Asn Ile Gly Ile Lys 
65                  70                  75                  80  


<210>  6573
<211>  2015
<212>  DNA
<213>  Homosapiens

<400>  6573
cggggccaga agagcgggct aagacgccgg aggaggtggc ggcggctggg agaggcgagg     60

gttctggccg attttagcat cgaaactagg agaaataaga atggctgtag aggaacttca    120

gtctataata aagagatgtc aaatcctaga agagcaagac tttaaagaag aggattttgg    180

cctatttcag ttagctgggc aaagatgcat agaagaaggg cacacagacc agctattaga    240

aattattcaa aatgaaaaga ataaggtcat catcaagaat atgggctgga atctcgttgg    300

tcctgttgtt cgatgccttt tgtgtaaaga taaagaggat agtaaaagaa aagtttattt    360

tttgatcttt gatttattgg taaagttatg caatccaaag gaattattgt tgggtttgct    420

tgaactgatt gaagagccct ctggaaaaca gatatcccaa agtattcttc ttttgcttca    480

gccattacaa acagtgattc agaaacttca taacaaggca tattcaattg gattagcatt    540

gtctaccctt tggaatcagc tatctcttct tcctgttcca tactcaaaag aacaaataca    600

aatggatgac tatggccttt gtcagtgttg caaggcctta atagagttca ctaagccttt    660

tgtggaagaa gtcattgata acaaagaaaa ctcactggaa aatgaaaagt taaaggatga    720

attactgaaa ttttgtttca aaagcttgaa atgccctttg ctgacagcac aattctttga    780

acagtctgaa gaaggtggaa atgatccttt caggtatttt gcatcagaaa taataggttt    840

tttatcagca attggacacc ctttccccaa aatgattttt aatcatggaa ggaaaaagag    900

aacttggaat taccttgaat ttgaagaaga agaaaataaa cagttagcag actcaatggc    960

ttctctggca tatctagtat ttgtacaggg catccatatt gatcagcttc caatggtctt   1020

aagcccattg taccttttgc agtttaatat ggggcacatt gaagtctttt tgcaaagaac   1080

agaagagtct gttatctcca aaggattgga gctgctggag aatagtttat tgagaataga   1140

agacaatagt ctactttacc agtacttaga aatcaagagt tttcttactg tacctcaggg   1200

cttagtgaaa gtaatgacac tttgccccat tgagacactg aggaaaaaga gtttagctat   1260

gcttcagctg tatattaaca agttggattc acaaggcaaa tatacattat ttaggtgctt   1320

attgaataca agtaatcact caggtgtgga ggcttttatt attcaaaata tcaaaaatca   1380

aattgacatg tcattaaaga gaacacgtaa caacaaatgg tttacaggac cacagttgat   1440

ttcccttctt gatttggtac tttttctccc agagggtgca gaaacagatt tactgcaaaa   1500

ctcagatagg attatggctt cattaaattt attgaggtat ttggttatca aagataatga   1560

aaatgacaat caaactggat tatggacaga acttggaaat attgagaata atttcttaaa   1620

gccacttcat ataggactta atatgtcaaa agcacattat gaagcagaaa ttaaaaatag   1680

ccaagaggcc cagaaatcta aagatctttg ttctataact gtaagtggag aagagatccc   1740

taatatgcct cctgaaatgc agcttaaggt cctgcattca gctcttttca catttgattt   1800

gattgaaagt gttctagctc gagtggaaga actcattgaa ataaaaacaa agtctacctc   1860

tgaagaaaat attgggataa agtgaaagtt ccatttccta aataaaaact aataaaatat   1920

agtactttcc attatgattc atttaatacc tttataaaaa atttttctgt aaaaatttac   1980

tgcttgaaaa ataaatgtag cttttctcat ttatc                              2015


<210>  6574
<211>  594
<212>  PRT
<213>  Homosapiens

<400>  6574

Met Ala Val Glu Glu Leu Gln Ser Ile Ile Lys Arg Cys Gln Ile Leu 
1               5                   10                  15      


Glu Glu Gln Asp Phe Lys Glu Glu Asp Phe Gly Leu Phe Gln Leu Ala 
            20                  25                  30          


Gly Gln Arg Cys Ile Glu Glu Gly His Thr Asp Gln Leu Leu Glu Ile 
        35                  40                  45              


Ile Gln Asn Glu Lys Asn Lys Val Ile Ile Lys Asn Met Gly Trp Asn 
    50                  55                  60                  


Leu Val Gly Pro Val Val Arg Cys Leu Leu Cys Lys Asp Lys Glu Asp 
65                  70                  75                  80  


Ser Lys Arg Lys Val Tyr Phe Leu Ile Phe Asp Leu Leu Val Lys Leu 
                85                  90                  95      


Cys Asn Pro Lys Glu Leu Leu Leu Gly Leu Leu Glu Leu Ile Glu Glu 
            100                 105                 110         


Pro Ser Gly Lys Gln Ile Ser Gln Ser Ile Leu Leu Leu Leu Gln Pro 
        115                 120                 125             


Leu Gln Thr Val Ile Gln Lys Leu His Asn Lys Ala Tyr Ser Ile Gly 
    130                 135                 140                 


Leu Ala Leu Ser Thr Leu Trp Asn Gln Leu Ser Leu Leu Pro Val Pro 
145                 150                 155                 160 


Tyr Ser Lys Glu Gln Ile Gln Met Asp Asp Tyr Gly Leu Cys Gln Cys 
                165                 170                 175     


Cys Lys Ala Leu Ile Glu Phe Thr Lys Pro Phe Val Glu Glu Val Ile 
            180                 185                 190         


Asp Asn Lys Glu Asn Ser Leu Glu Asn Glu Lys Leu Lys Asp Glu Leu 
        195                 200                 205             


Leu Lys Phe Cys Phe Lys Ser Leu Lys Cys Pro Leu Leu Thr Ala Gln 
    210                 215                 220                 


Phe Phe Glu Gln Ser Glu Glu Gly Gly Asn Asp Pro Phe Arg Tyr Phe 
225                 230                 235                 240 


Ala Ser Glu Ile Ile Gly Phe Leu Ser Ala Ile Gly His Pro Phe Pro 
                245                 250                 255     


Lys Met Ile Phe Asn His Gly Arg Lys Lys Arg Thr Trp Asn Tyr Leu 
            260                 265                 270         


Glu Phe Glu Glu Glu Glu Asn Lys Gln Leu Ala Asp Ser Met Ala Ser 
        275                 280                 285             


Leu Ala Tyr Leu Val Phe Val Gln Gly Ile His Ile Asp Gln Leu Pro 
    290                 295                 300                 


Met Val Leu Ser Pro Leu Tyr Leu Leu Gln Phe Asn Met Gly His Ile 
305                 310                 315                 320 


Glu Val Phe Leu Gln Arg Thr Glu Glu Ser Val Ile Ser Lys Gly Leu 
                325                 330                 335     


Glu Leu Leu Glu Asn Ser Leu Leu Arg Ile Glu Asp Asn Ser Leu Leu 
            340                 345                 350         


Tyr Gln Tyr Leu Glu Ile Lys Ser Phe Leu Thr Val Pro Gln Gly Leu 
        355                 360                 365             


Val Lys Val Met Thr Leu Cys Pro Ile Glu Thr Leu Arg Lys Lys Ser 
    370                 375                 380                 


Leu Ala Met Leu Gln Leu Tyr Ile Asn Lys Leu Asp Ser Gln Gly Lys 
385                 390                 395                 400 


Tyr Thr Leu Phe Arg Cys Leu Leu Asn Thr Ser Asn His Ser Gly Val 
                405                 410                 415     


Glu Ala Phe Ile Ile Gln Asn Ile Lys Asn Gln Ile Asp Met Ser Leu 
            420                 425                 430         


Lys Arg Thr Arg Asn Asn Lys Trp Phe Thr Gly Pro Gln Leu Ile Ser 
        435                 440                 445             


Leu Leu Asp Leu Val Leu Phe Leu Pro Glu Gly Ala Glu Thr Asp Leu 
    450                 455                 460                 


Leu Gln Asn Ser Asp Arg Ile Met Ala Ser Leu Asn Leu Leu Arg Tyr 
465                 470                 475                 480 


Leu Val Ile Lys Asp Asn Glu Asn Asp Asn Gln Thr Gly Leu Trp Thr 
                485                 490                 495     


Glu Leu Gly Asn Ile Glu Asn Asn Phe Leu Lys Pro Leu His Ile Gly 
            500                 505                 510         


Leu Asn Met Ser Lys Ala His Tyr Glu Ala Glu Ile Lys Asn Ser Gln 
        515                 520                 525             


Glu Ala Gln Lys Ser Lys Asp Leu Cys Ser Ile Thr Val Ser Gly Glu 
    530                 535                 540                 


Glu Ile Pro Asn Met Pro Pro Glu Met Gln Leu Lys Val Leu His Ser 
545                 550                 555                 560 


Ala Leu Phe Thr Phe Asp Leu Ile Glu Ser Val Leu Ala Arg Val Glu 
                565                 570                 575     


Glu Leu Ile Glu Ile Lys Thr Lys Ser Thr Ser Glu Glu Asn Ile Gly 
            580                 585                 590         


Ile Lys 
        


<210>  6575
<211>  1930
<212>  DNA
<213>  Homosapiens

<400>  6575
cggggccaga agagcgggct aagacgccgg aggaggtggc ggcggctggg agaggcgagg     60

gttctggccg attttagcat cgaaactagg agaaataaga atggctgtag aggaacttca    120

gtctataata aagagatgtc aaatcctaga agagcaagac tttaaagaag aggattttgg    180

cctatttcag ttagctgggc aaagatgcat agaagaaggg cacacagacc agctattaga    240

aattattcaa aatgaaaaga ataaggtcat catcaagaat atgggctgga atctcgttgg    300

tcctgttgtt cgatgccttt tgtgtaaaga taaagaggat agtaaaagaa aagtttattt    360

tttgatcttt gatttattgg taaagttatg caatccaaag gaattattgt tgggtttgct    420

tgaactgatt gaagagccct ctggaaaaca gatatcccaa agtattcttc ttttgcttca    480

gccattacaa acagtgattc agaaacttca taacaaggca tattcaattg gattagcatt    540

gtctaccctt tggaatcagc tatctcttct tcctgttcca tactcaaaag aacaaataca    600

aatggatgac tatggccttt gtcagtgttg caaggcctta atagagttca ctaagccttt    660

tgtggaagaa gtcattgata acaaagaaaa ctcactggaa aatgaaaagt taaaggatga    720

attactgaaa ttttgtttca aaagcttgaa atgccctttg ctgacagcac aattctttga    780

acagtctgaa gaaggtggaa atgatccttt caggtatttt gcatcagaaa taataggttt    840

tttatcagca attggacacc ctttccccaa aatgattttt aatcatggaa ggaaaaagag    900

aacttggaat taccttgaat ttgaagaaga agaaaataaa cagttagcag actcaatggc    960

ttctctggca tatctagtat ttgtacaggg catccatatt gatcagcttc caatggtctt   1020

aagcccattg taccttttgc agtttaatat ggggcacatt gaagtctttt tgcaaagaac   1080

agaagagtct gttatctcca aaggattgga gctgctggag aatagtttat tgagaataga   1140

agacaatagt ctactttacc agtacttaga aatcaagagt tttcttactg tacctcaggg   1200

cttagtgaaa gtaatgacac tttgccccat tgagacactg aggaaaaaga gtttagctat   1260

gcttcagctg tatattaaca agttggattc acaaggcaaa tatacattat ttagagaaca   1320

cgtaacaaca aatggtttac aggaccacag ttgatttccc ttcttgattt ggtacttttt   1380

ctcccagagg gtgcagaaac agatttactg caaaactcag ataggattat ggcttcatta   1440

aatttattga ggtatttggt tatcaaagat aatgaaaatg acaatcaaac tggattatgg   1500

acagaacttg gaaatattga gaataatttc ttaaagccac ttcatatagg acttaatatg   1560

tcaaaagcac attatgaagc agaaattaaa aatagccaag aggcccagaa atctaaagat   1620

ctttgttcta taactgtaag tggagaagag atccctaata tgcctcctga aatgcagctt   1680

aaggtcctgc attcagctct tttcacattt gatttgattg aaagtgttct agctcgagtg   1740

gaagaactca ttgaaataaa aacaaagtct acctctgaag aaaatattgg gataaagtga   1800

aagttccatt tcctaaataa aaactaataa aatatagtac tttccattat gattcattta   1860

atacctttat aaaaaatttt tctgtaaaaa tttactgctt gaaaaataaa tgtagctttt   1920

ctcatttatc                                                          1930


<210>  6576
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  6576

Met Ala Val Glu Glu Leu Gln Ser Ile Ile Lys Arg Cys Gln Ile Leu 
1               5                   10                  15      


Glu Glu Gln Asp Phe Lys Glu Glu Asp Phe Gly Leu Phe Gln Leu Ala 
            20                  25                  30          


Gly Gln Arg Cys Ile Glu Glu Gly His Thr Asp Gln Leu Leu Glu Ile 
        35                  40                  45              


Ile Gln Asn Glu Lys Asn Lys Val Ile Ile Lys Asn Met Gly Trp Asn 
    50                  55                  60                  


Leu Val Gly Pro Val Val Arg Cys Leu Leu Cys Lys Asp Lys Glu Asp 
65                  70                  75                  80  


Ser Lys Arg Lys Val Tyr Phe Leu Ile Phe Asp Leu Leu Val Lys Leu 
                85                  90                  95      


Cys Asn Pro Lys Glu Leu Leu Leu Gly Leu Leu Glu Leu Ile Glu Glu 
            100                 105                 110         


Pro Ser Gly Lys Gln Ile Ser Gln Ser Ile Leu Leu Leu Leu Gln Pro 
        115                 120                 125             


Leu Gln Thr Val Ile Gln Lys Leu His Asn Lys Ala Tyr Ser Ile Gly 
    130                 135                 140                 


Leu Ala Leu Ser Thr Leu Trp Asn Gln Leu Ser Leu Leu Pro Val Pro 
145                 150                 155                 160 


Tyr Ser Lys Glu Gln Ile Gln Met Asp Asp Tyr Gly Leu Cys Gln Cys 
                165                 170                 175     


Cys Lys Ala Leu Ile Glu Phe Thr Lys Pro Phe Val Glu Glu Val Ile 
            180                 185                 190         


Asp Asn Lys Glu Asn Ser Leu Glu Asn Glu Lys Leu Lys Asp Glu Leu 
        195                 200                 205             


Leu Lys Phe Cys Phe Lys Ser Leu Lys Cys Pro Leu Leu Thr Ala Gln 
    210                 215                 220                 


Phe Phe Glu Gln Ser Glu Glu Gly Gly Asn Asp Pro Phe Arg Tyr Phe 
225                 230                 235                 240 


Ala Ser Glu Ile Ile Gly Phe Leu Ser Ala Ile Gly His Pro Phe Pro 
                245                 250                 255     


Lys Met Ile Phe Asn His Gly Arg Lys Lys Arg Thr Trp Asn Tyr Leu 
            260                 265                 270         


Glu Phe Glu Glu Glu Glu Asn Lys Gln Leu Ala Asp Ser Met Ala Ser 
        275                 280                 285             


Leu Ala Tyr Leu Val Phe Val Gln Gly Ile His Ile Asp Gln Leu Pro 
    290                 295                 300                 


Met Val Leu Ser Pro Leu Tyr Leu Leu Gln Phe Asn Met Gly His Ile 
305                 310                 315                 320 


Glu Val Phe Leu Gln Arg Thr Glu Glu Ser Val Ile Ser Lys Gly Leu 
                325                 330                 335     


Glu Leu Leu Glu Asn Ser Leu Leu Arg Ile Glu Asp Asn Ser Leu Leu 
            340                 345                 350         


Tyr Gln Tyr Leu Glu Ile Lys Ser Phe Leu Thr Val Pro Gln Gly Leu 
        355                 360                 365             


Val Lys Val Met Thr Leu Cys Pro Ile Glu Thr Leu Arg Lys Lys Ser 
    370                 375                 380                 


Leu Ala Met Leu Gln Leu Tyr Ile Asn Lys Leu Asp Ser Gln Gly Lys 
385                 390                 395                 400 


Tyr Thr Leu Phe Arg Glu His Val Thr Thr Asn Gly Leu Gln Asp His 
                405                 410                 415     


Ser 
    


<210>  6577
<211>  850
<212>  DNA
<213>  Homosapiens

<400>  6577
gggaaagcat cctctagaac tagatccgtg gtgtggatat caattgaaag gccatacttg     60

ggatgaaggc ataaataagg tagagtcatt gtggagatgg ctcatagagg aagagacgtc    120

tgtgaattta tcctcaaata attttctcat aaataaaact taacaagtta atagatctca    180

aaacctggag ctatccaaat ggtgcagtga taagcgtagt gccccaagta catttttctt    240

ttaattggta ttcacataac tagctatagt aataattatt aaatagtgaa gtccattgtg    300

aaaagcaagg gccatgtttc atttattttt gttttttgag cttttatcgc gtttaatagt    360

aggcaatcaa tcattgttga actaaataac tcattctttc attcttaaca gactggatta    420

tggacagaac ttggaaatat tgagaataat ttcttaaagc cacttcatat aggacttaat    480

atgtcaaaag cacattatga agcagaaatt aaaaatagcc aagaggccca gaaatctaaa    540

gatctttgtt ctataactgt aagtggagaa gagatcccta atatgcctcc tgaaatgcag    600

cttaaggtcc tgcattcagc tcttttcaca tttgatttga ttgaaagtgt tctagctcga    660

gtggaagaac tcattgaaat aaaaacaaag tctacctctg aagaaaatat tgggataaag    720

tgaaagttcc atttcctaaa taaaaactaa taaaatatag tactttccat tatgattcat    780

ttaatacctt tataaaaaat ttttctgtaa aaatttactg cttgaaaaat aaatgtagct    840

tttctcattt                                                           850


<210>  6578
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  6578

Met Ser Lys Ala His Tyr Glu Ala Glu Ile Lys Asn Ser Gln Glu Ala 
1               5                   10                  15      


Gln Lys Ser Lys Asp Leu Cys Ser Ile Thr Val Ser Gly Glu Glu Ile 
            20                  25                  30          


Pro Asn Met Pro Pro Glu Met Gln Leu Lys Val Leu His Ser Ala Leu 
        35                  40                  45              


Phe Thr Phe Asp Leu Ile Glu Ser Val Leu Ala Arg Val Glu Glu Leu 
    50                  55                  60                  


Ile Glu Ile Lys Thr Lys Ser Thr Ser Glu Glu Asn Ile Gly Ile Lys 
65                  70                  75                  80  


<210>  6579
<211>  536
<212>  DNA
<213>  Homosapiens

<400>  6579
atttactgaa ttatcttggc aactttatca aaaatcattt tataagtatg ggtctatttt     60

tggactctat tccatttacc tgtatctatt cttttaccaa taccacactg tcttgattcc    120

tttataggaa gaaattattc tgttttattc ctttatagga agtcttgacc tcaagtaata    180

ctggattatg gacagaactt ggaaatattg agaataattt cttaaagcca cttcatatag    240

gacttaatat gtcaaaagca cattatgaag cagaaattaa aaatagccaa gaggcccaga    300

aatctaaaga tctttgttct ataactgtaa gtggagaaga gatccctaat atgcctcctg    360

aaatgcagct taaggtcctg cattcagctc ttttcacatt tgatttgatt gaaagtgttc    420

tagctcgagt ggaagaactc attgaaataa aaacaaagtc tacctctgaa gaaaatattg    480

ggataaagtg aaagttccat ttcctaaata aaaactaata aaatatagta ctttcc        536


<210>  6580
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  6580

Met Ser Lys Ala His Tyr Glu Ala Glu Ile Lys Asn Ser Gln Glu Ala 
1               5                   10                  15      


Gln Lys Ser Lys Asp Leu Cys Ser Ile Thr Val Ser Gly Glu Glu Ile 
            20                  25                  30          


Pro Asn Met Pro Pro Glu Met Gln Leu Lys Val Leu His Ser Ala Leu 
        35                  40                  45              


Phe Thr Phe Asp Leu Ile Glu Ser Val Leu Ala Arg Val Glu Glu Leu 
    50                  55                  60                  


Ile Glu Ile Lys Thr Lys Ser Thr Ser Glu Glu Asn Ile Gly Ile Lys 
65                  70                  75                  80  


<210>  6581
<211>  1930
<212>  DNA
<213>  Homosapiens

<400>  6581
cggggccaga agagcgggct aagacgccgg aggaggtggc ggcggctggg agaggcgagg     60

gttctggccg attttagcat cgaaactagg agaaataaga atggctgtag aggaacttca    120

gtctataata aagagatgtc aaatcctaga agagcaagac tttaaagaag aggattttgg    180

cctatttcag ttagctgggc aaagatgcat agaagaaggg cacacagacc agctattaga    240

aattattcaa aatgaaaaga ataaggtcat catcaagaat atgggctgga atctcgttgg    300

tcctgttgtt cgatgccttt tgtgtaaaga taaagaggat agtaaaagaa aagtttattt    360

tttgatcttt gatttattgg taaagttatg caatccaaag gaattattgt tgggtttgct    420

tgaactgatt gaagagccct ctggaaaaca gatatcccaa agtattcttc ttttgcttca    480

gccattacaa acagtgattc agaaacttca taacaaggca tattcaattg gattagcatt    540

gtctaccctt tggaatcagc tatctcttct tcctgttcca tactcaaaag aacaaataca    600

aatggatgac tatggccttt gtcagtgttg caaggcctta atagagttca ctaagccttt    660

tgtggaagaa gtcattgata acaaagaaaa ctcactggaa aatgaaaagt taaaggatga    720

attactgaaa ttttgtttca aaagcttgaa atgccctttg ctgacagcac aattctttga    780

acagtctgaa gaaggtggaa atgatccttt caggtatttt gcatcagaaa taataggttt    840

tttatcagca attggacacc ctttccccaa aatgattttt aatcatggaa ggaaaaagag    900

aacttggaat taccttgaat ttgaagaaga agaaaataaa cagttagcag actcaatggc    960

ttctctggca tatctagtat ttgtacaggg catccatatt gatcagcttc caatggtctt   1020

aagcccattg taccttttgc agtttaatat ggggcacatt gaagtctttt tgcaaagaac   1080

agaagagtct gttatctcca aaggattgga gctgctggag aatagtttat tgagaataga   1140

agacaatagt ctactttacc agtacttaga aatcaagagt tttcttactg tacctcaggg   1200

cttagtgaaa gtaatgacac tttgccccat tgagacactg aggaaaaaga gtttagctat   1260

gcttcagctg tatattaaca agttggattc acaaggcaaa tatacattat ttaggtgctt   1320

attgaataca agtaatcact caggtgtgga ggcttttatt attcaaaata tcaaaaatca   1380

aattgacatg tcattaaaga gaacacgtaa caacaaatgg tttacaggac cacagttgat   1440

ttcccttctt gatttggtac tttttctccc agagggtgca gaaacagatt tactgcaaaa   1500

ctcagatagg attatggctt cattaaattt attgaggtat ttggttatca aagataatga   1560

aaatgacaat caaactggat tatggacaga acttggaaat attgagaata atttcttaaa   1620

gccacttcat ataggactta atatgtcaaa agcacattat gaagcagaaa ttaaaaatag   1680

ccaagaggcc cagaaatcta aagatctttg ttctataact gtaagtggag aagagatccc   1740

taatatgcct cctgaaatgc agcttaaggt cctgcattca gctcttttca catttgattt   1800

gattgaaagt gttctagctc gagtggaaga actcattgaa ataaaaacaa agtctacctc   1860

tgaagaaaat attgggataa agtgaaagtt ccatttccta aataaaaact aataaaatat   1920

agtactttcc                                                          1930


<210>  6582
<211>  594
<212>  PRT
<213>  Homosapiens

<400>  6582

Met Ala Val Glu Glu Leu Gln Ser Ile Ile Lys Arg Cys Gln Ile Leu 
1               5                   10                  15      


Glu Glu Gln Asp Phe Lys Glu Glu Asp Phe Gly Leu Phe Gln Leu Ala 
            20                  25                  30          


Gly Gln Arg Cys Ile Glu Glu Gly His Thr Asp Gln Leu Leu Glu Ile 
        35                  40                  45              


Ile Gln Asn Glu Lys Asn Lys Val Ile Ile Lys Asn Met Gly Trp Asn 
    50                  55                  60                  


Leu Val Gly Pro Val Val Arg Cys Leu Leu Cys Lys Asp Lys Glu Asp 
65                  70                  75                  80  


Ser Lys Arg Lys Val Tyr Phe Leu Ile Phe Asp Leu Leu Val Lys Leu 
                85                  90                  95      


Cys Asn Pro Lys Glu Leu Leu Leu Gly Leu Leu Glu Leu Ile Glu Glu 
            100                 105                 110         


Pro Ser Gly Lys Gln Ile Ser Gln Ser Ile Leu Leu Leu Leu Gln Pro 
        115                 120                 125             


Leu Gln Thr Val Ile Gln Lys Leu His Asn Lys Ala Tyr Ser Ile Gly 
    130                 135                 140                 


Leu Ala Leu Ser Thr Leu Trp Asn Gln Leu Ser Leu Leu Pro Val Pro 
145                 150                 155                 160 


Tyr Ser Lys Glu Gln Ile Gln Met Asp Asp Tyr Gly Leu Cys Gln Cys 
                165                 170                 175     


Cys Lys Ala Leu Ile Glu Phe Thr Lys Pro Phe Val Glu Glu Val Ile 
            180                 185                 190         


Asp Asn Lys Glu Asn Ser Leu Glu Asn Glu Lys Leu Lys Asp Glu Leu 
        195                 200                 205             


Leu Lys Phe Cys Phe Lys Ser Leu Lys Cys Pro Leu Leu Thr Ala Gln 
    210                 215                 220                 


Phe Phe Glu Gln Ser Glu Glu Gly Gly Asn Asp Pro Phe Arg Tyr Phe 
225                 230                 235                 240 


Ala Ser Glu Ile Ile Gly Phe Leu Ser Ala Ile Gly His Pro Phe Pro 
                245                 250                 255     


Lys Met Ile Phe Asn His Gly Arg Lys Lys Arg Thr Trp Asn Tyr Leu 
            260                 265                 270         


Glu Phe Glu Glu Glu Glu Asn Lys Gln Leu Ala Asp Ser Met Ala Ser 
        275                 280                 285             


Leu Ala Tyr Leu Val Phe Val Gln Gly Ile His Ile Asp Gln Leu Pro 
    290                 295                 300                 


Met Val Leu Ser Pro Leu Tyr Leu Leu Gln Phe Asn Met Gly His Ile 
305                 310                 315                 320 


Glu Val Phe Leu Gln Arg Thr Glu Glu Ser Val Ile Ser Lys Gly Leu 
                325                 330                 335     


Glu Leu Leu Glu Asn Ser Leu Leu Arg Ile Glu Asp Asn Ser Leu Leu 
            340                 345                 350         


Tyr Gln Tyr Leu Glu Ile Lys Ser Phe Leu Thr Val Pro Gln Gly Leu 
        355                 360                 365             


Val Lys Val Met Thr Leu Cys Pro Ile Glu Thr Leu Arg Lys Lys Ser 
    370                 375                 380                 


Leu Ala Met Leu Gln Leu Tyr Ile Asn Lys Leu Asp Ser Gln Gly Lys 
385                 390                 395                 400 


Tyr Thr Leu Phe Arg Cys Leu Leu Asn Thr Ser Asn His Ser Gly Val 
                405                 410                 415     


Glu Ala Phe Ile Ile Gln Asn Ile Lys Asn Gln Ile Asp Met Ser Leu 
            420                 425                 430         


Lys Arg Thr Arg Asn Asn Lys Trp Phe Thr Gly Pro Gln Leu Ile Ser 
        435                 440                 445             


Leu Leu Asp Leu Val Leu Phe Leu Pro Glu Gly Ala Glu Thr Asp Leu 
    450                 455                 460                 


Leu Gln Asn Ser Asp Arg Ile Met Ala Ser Leu Asn Leu Leu Arg Tyr 
465                 470                 475                 480 


Leu Val Ile Lys Asp Asn Glu Asn Asp Asn Gln Thr Gly Leu Trp Thr 
                485                 490                 495     


Glu Leu Gly Asn Ile Glu Asn Asn Phe Leu Lys Pro Leu His Ile Gly 
            500                 505                 510         


Leu Asn Met Ser Lys Ala His Tyr Glu Ala Glu Ile Lys Asn Ser Gln 
        515                 520                 525             


Glu Ala Gln Lys Ser Lys Asp Leu Cys Ser Ile Thr Val Ser Gly Glu 
    530                 535                 540                 


Glu Ile Pro Asn Met Pro Pro Glu Met Gln Leu Lys Val Leu His Ser 
545                 550                 555                 560 


Ala Leu Phe Thr Phe Asp Leu Ile Glu Ser Val Leu Ala Arg Val Glu 
                565                 570                 575     


Glu Leu Ile Glu Ile Lys Thr Lys Ser Thr Ser Glu Glu Asn Ile Gly 
            580                 585                 590         


Ile Lys 
        


<210>  6583
<211>  1845
<212>  DNA
<213>  Homosapiens

<400>  6583
cggggccaga agagcgggct aagacgccgg aggaggtggc ggcggctggg agaggcgagg     60

gttctggccg attttagcat cgaaactagg agaaataaga atggctgtag aggaacttca    120

gtctataata aagagatgtc aaatcctaga agagcaagac tttaaagaag aggattttgg    180

cctatttcag ttagctgggc aaagatgcat agaagaaggg cacacagacc agctattaga    240

aattattcaa aatgaaaaga ataaggtcat catcaagaat atgggctgga atctcgttgg    300

tcctgttgtt cgatgccttt tgtgtaaaga taaagaggat agtaaaagaa aagtttattt    360

tttgatcttt gatttattgg taaagttatg caatccaaag gaattattgt tgggtttgct    420

tgaactgatt gaagagccct ctggaaaaca gatatcccaa agtattcttc ttttgcttca    480

gccattacaa acagtgattc agaaacttca taacaaggca tattcaattg gattagcatt    540

gtctaccctt tggaatcagc tatctcttct tcctgttcca tactcaaaag aacaaataca    600

aatggatgac tatggccttt gtcagtgttg caaggcctta atagagttca ctaagccttt    660

tgtggaagaa gtcattgata acaaagaaaa ctcactggaa aatgaaaagt taaaggatga    720

attactgaaa ttttgtttca aaagcttgaa atgccctttg ctgacagcac aattctttga    780

acagtctgaa gaaggtggaa atgatccttt caggtatttt gcatcagaaa taataggttt    840

tttatcagca attggacacc ctttccccaa aatgattttt aatcatggaa ggaaaaagag    900

aacttggaat taccttgaat ttgaagaaga agaaaataaa cagttagcag actcaatggc    960

ttctctggca tatctagtat ttgtacaggg catccatatt gatcagcttc caatggtctt   1020

aagcccattg taccttttgc agtttaatat ggggcacatt gaagtctttt tgcaaagaac   1080

agaagagtct gttatctcca aaggattgga gctgctggag aatagtttat tgagaataga   1140

agacaatagt ctactttacc agtacttaga aatcaagagt tttcttactg tacctcaggg   1200

cttagtgaaa gtaatgacac tttgccccat tgagacactg aggaaaaaga gtttagctat   1260

gcttcagctg tatattaaca agttggattc acaaggcaaa tatacattat ttagagaaca   1320

cgtaacaaca aatggtttac aggaccacag ttgatttccc ttcttgattt ggtacttttt   1380

ctcccagagg gtgcagaaac agatttactg caaaactcag ataggattat ggcttcatta   1440

aatttattga ggtatttggt tatcaaagat aatgaaaatg acaatcaaac tggattatgg   1500

acagaacttg gaaatattga gaataatttc ttaaagccac ttcatatagg acttaatatg   1560

tcaaaagcac attatgaagc agaaattaaa aatagccaag aggcccagaa atctaaagat   1620

ctttgttcta taactgtaag tggagaagag atccctaata tgcctcctga aatgcagctt   1680

aaggtcctgc attcagctct tttcacattt gatttgattg aaagtgttct agctcgagtg   1740

gaagaactca ttgaaataaa aacaaagtct acctctgaag aaaatattgg gataaagtga   1800

aagttccatt tcctaaataa aaactaataa aatatagtac tttcc                   1845


<210>  6584
<211>  417
<212>  PRT
<213>  Homosapiens

<400>  6584

Met Ala Val Glu Glu Leu Gln Ser Ile Ile Lys Arg Cys Gln Ile Leu 
1               5                   10                  15      


Glu Glu Gln Asp Phe Lys Glu Glu Asp Phe Gly Leu Phe Gln Leu Ala 
            20                  25                  30          


Gly Gln Arg Cys Ile Glu Glu Gly His Thr Asp Gln Leu Leu Glu Ile 
        35                  40                  45              


Ile Gln Asn Glu Lys Asn Lys Val Ile Ile Lys Asn Met Gly Trp Asn 
    50                  55                  60                  


Leu Val Gly Pro Val Val Arg Cys Leu Leu Cys Lys Asp Lys Glu Asp 
65                  70                  75                  80  


Ser Lys Arg Lys Val Tyr Phe Leu Ile Phe Asp Leu Leu Val Lys Leu 
                85                  90                  95      


Cys Asn Pro Lys Glu Leu Leu Leu Gly Leu Leu Glu Leu Ile Glu Glu 
            100                 105                 110         


Pro Ser Gly Lys Gln Ile Ser Gln Ser Ile Leu Leu Leu Leu Gln Pro 
        115                 120                 125             


Leu Gln Thr Val Ile Gln Lys Leu His Asn Lys Ala Tyr Ser Ile Gly 
    130                 135                 140                 


Leu Ala Leu Ser Thr Leu Trp Asn Gln Leu Ser Leu Leu Pro Val Pro 
145                 150                 155                 160 


Tyr Ser Lys Glu Gln Ile Gln Met Asp Asp Tyr Gly Leu Cys Gln Cys 
                165                 170                 175     


Cys Lys Ala Leu Ile Glu Phe Thr Lys Pro Phe Val Glu Glu Val Ile 
            180                 185                 190         


Asp Asn Lys Glu Asn Ser Leu Glu Asn Glu Lys Leu Lys Asp Glu Leu 
        195                 200                 205             


Leu Lys Phe Cys Phe Lys Ser Leu Lys Cys Pro Leu Leu Thr Ala Gln 
    210                 215                 220                 


Phe Phe Glu Gln Ser Glu Glu Gly Gly Asn Asp Pro Phe Arg Tyr Phe 
225                 230                 235                 240 


Ala Ser Glu Ile Ile Gly Phe Leu Ser Ala Ile Gly His Pro Phe Pro 
                245                 250                 255     


Lys Met Ile Phe Asn His Gly Arg Lys Lys Arg Thr Trp Asn Tyr Leu 
            260                 265                 270         


Glu Phe Glu Glu Glu Glu Asn Lys Gln Leu Ala Asp Ser Met Ala Ser 
        275                 280                 285             


Leu Ala Tyr Leu Val Phe Val Gln Gly Ile His Ile Asp Gln Leu Pro 
    290                 295                 300                 


Met Val Leu Ser Pro Leu Tyr Leu Leu Gln Phe Asn Met Gly His Ile 
305                 310                 315                 320 


Glu Val Phe Leu Gln Arg Thr Glu Glu Ser Val Ile Ser Lys Gly Leu 
                325                 330                 335     


Glu Leu Leu Glu Asn Ser Leu Leu Arg Ile Glu Asp Asn Ser Leu Leu 
            340                 345                 350         


Tyr Gln Tyr Leu Glu Ile Lys Ser Phe Leu Thr Val Pro Gln Gly Leu 
        355                 360                 365             


Val Lys Val Met Thr Leu Cys Pro Ile Glu Thr Leu Arg Lys Lys Ser 
    370                 375                 380                 


Leu Ala Met Leu Gln Leu Tyr Ile Asn Lys Leu Asp Ser Gln Gly Lys 
385                 390                 395                 400 


Tyr Thr Leu Phe Arg Glu His Val Thr Thr Asn Gly Leu Gln Asp His 
                405                 410                 415     


Ser 
    


<210>  6585
<211>  767
<212>  DNA
<213>  Homosapiens

<400>  6585
gggaaagcat cctctagaac tagatccgtg gtgtggatat caattgaaag gccatacttg     60

ggatgaaggc ataaataagg tagagtcatt gtggagatgg ctcatagagg aagagacgtc    120

tgtgaattta tcctcaaata attttctcat aaataaaact taacaagtta atagatctca    180

aaacctggag ctatccaaat ggtgcagtga taagcgtagt gccccaagta catttttctt    240

ttaattggta ttcacataac tagctatagt aataattatt aaatagtgaa gtccattgtg    300

aaaagcaagg gccatgtttc atttattttt gttttttgag cttttatcgc gtttaatagt    360

aggcaatcaa tcattgttga actaaataac tcattctttc attcttaaca gactggatta    420

tggacagaac ttggaaatat tgagaataat ttcttaaagc cacttcatat aggacttaat    480

atgtcaaaag cacattatga agcagaaatt aaaaatagcc aagaggccca gaaatctaaa    540

gatctttgtt ctataactgt aagtggagaa gagatcccta atatgcctcc tgaaatgcag    600

cttaaggtcc tgcattcagc tcttttcaca tttgatttga ttgaaagtgt tctagctcga    660

gtggaagaac tcattgaaat aaaaacaaag tctacctctg aagaaaatat tgggataaag    720

tgaaagttcc atttcctaaa taaaaactaa taaaatatag tactttc                  767


<210>  6586
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  6586

Met Ser Lys Ala His Tyr Glu Ala Glu Ile Lys Asn Ser Gln Glu Ala 
1               5                   10                  15      


Gln Lys Ser Lys Asp Leu Cys Ser Ile Thr Val Ser Gly Glu Glu Ile 
            20                  25                  30          


Pro Asn Met Pro Pro Glu Met Gln Leu Lys Val Leu His Ser Ala Leu 
        35                  40                  45              


Phe Thr Phe Asp Leu Ile Glu Ser Val Leu Ala Arg Val Glu Glu Leu 
    50                  55                  60                  


Ile Glu Ile Lys Thr Lys Ser Thr Ser Glu Glu Asn Ile Gly Ile Lys 
65                  70                  75                  80  


<210>  6587
<211>  912
<212>  DNA
<213>  Homosapiens

<400>  6587
ggaggaggtg gcggcggctg ggagaggcga gggttctggc cgattttagc atcgaaacta     60

ggagaaataa gaatggctgt agaggaactt cagtctataa taaagagatg tcaaatccta    120

gaagagcaag actttaaaga agaggatttt ggcctatttc agttagctgg gcaaagatgc    180

atagaagaag ggcacacaga ccagctatta gaaattattc aaaatgaaaa gaataaggtg    240

cgtacaatct tggtgtttac ttttcagtct tgggaagaga ataatcacat gatgctattc    300

atccagtcat ttatccatca aacatttaag aatctactta aattttcaca gtagggaact    360

gaaaacaaaa aaagaattag aaatatttag gccaggcgca gtggctcacg ttcgtaatca    420

cagcgttatg ggaggccaag gcaggcagat cacttgagcc caggagtttg agaccagcct    480

gggcaacaga gtaagaccct gtctcagaaa aaaaaaaaaa aaaaagaaaa gaaacagtca    540

tatacttgaa ggtttttacc atctggtcaa acataaacat gtaaacaact aacaataatg    600

aggcaaaata aataattgct atagttgaag taaagagttt ttagaagaaa cagaattact    660

tctggtttag ggagtccaaa aatggtgttt gagtcattaa tttacaatga gaaatataca    720

tatcaagcag gctaaatatt cattttgggt gatcagccca ttctcctcca gccaaatgtg    780

tatggaaaac caaattttaa ttaaaacagt attttatgtg catagaatca gaacaggagg    840

aaaacgatat gtcattatac tagccagtat catccagtta caatggtttg agaaatcatc    900

ctccacaatg ga                                                        912


<210>  6588
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  6588

Met Ala Val Glu Glu Leu Gln Ser Ile Ile Lys Arg Cys Gln Ile Leu 
1               5                   10                  15      


Glu Glu Gln Asp Phe Lys Glu Glu Asp Phe Gly Leu Phe Gln Leu Ala 
            20                  25                  30          


Gly Gln Arg Cys Ile Glu Glu Gly His Thr Asp Gln Leu Leu Glu Ile 
        35                  40                  45              


Ile Gln Asn Glu Lys Asn Lys Val Arg Thr Ile Leu Val Phe Thr Phe 
    50                  55                  60                  


Gln Ser Trp Glu Glu Asn Asn His Met Met Leu Phe Ile Gln Ser Phe 
65                  70                  75                  80  


Ile His Gln Thr Phe Lys Asn Leu Leu Lys Phe Ser Gln 
                85                  90              


<210>  6589
<211>  1364
<212>  DNA
<213>  Homosapiens

<400>  6589
agaagagcgg gctaagacgc cggaggaggt ggcggcggct gggagaggcg agggttctgg     60

ccgattttag catcgaaact aggagaaata agaatggctg tagaggaact tcagtctata    120

ataaagagat gtgtaagtat taatttttgt aaaattaaat acctttcaaa atatgggaag    180

ggcacagatt gtttttaatt atatttgtgg tcactcaaat tgtttatctt ctttaatcct    240

tgcttttttt gacctgtaaa gagcatgagt gggggaggca gattggatta tttctccagg    300

tgacatactt atctaaataa ccttttacat tttaatcctg atccttttca tagatttcac    360

tggtacagta gatttcaagg tcacttatta aagtatttat tagggtaatc ctaattttga    420

tacgtgtgtt atttacgtta catttatcta gaatttaaac agatttcctt ttttcataga    480

taaatcaaga agttattgta tttaattttt atttgcatat actttttttt gtttgttttt    540

tgggtttttt ttttttttgc cagcaaatcc tagaagagca agactttaaa gaagaggatt    600

ttggcctatt tcagttagct gggcaaagat gcatagaaga agggcacaca gaccagctat    660

tagaaattat tcaaaatgaa aagaataagg tgcgtacaat cttggtgttt acttttcagt    720

cttgggaaga gaataatcac atgatgctat tcatccagtc atttatccat caaacattta    780

agaatctact taaattttca cagtagggaa ctgaaaacaa aaaaagaatt agaaatattt    840

aggccaggcg cagtggctca cgttcgtaat cacagcgtta tgggaggcca aggcaggcag    900

atcacttgag cccaggagtt tgagaccagc ctgggcaaca gagtaagacc ctgtctcaga    960

aaaaaaaaaa aaaaaaagaa aagaaacagt catatacttg aaggttttta ccatctggtc   1020

aaacataaac atgtaaacaa ctaacaataa tgaggcaaaa taaataattg ctatagttga   1080

agtaaagagt ttttagaaga aacagaatta cttctggttt agggagtcca aaaatggtgt   1140

ttgagtcatt aatttacaat gagaaatata catatcaagc aggctaaata ttcattttgg   1200

gtgatcagcc cattctcctc cagccaaatg tgtatggaaa accaaatttt aattaaaaca   1260

gtattttatg tgcatagaat cagaacagga ggaaaacgat atgtcattat actagccagt   1320

atcatccagt tacaatggtt tgagaaatca tcctccacaa tgga                    1364


<210>  6590
<211>  67
<212>  PRT
<213>  Homosapiens

<400>  6590

Met Arg Asn Ile His Ile Lys Gln Ala Lys Tyr Ser Phe Trp Val Ile 
1               5                   10                  15      


Ser Pro Phe Ser Ser Ser Gln Met Cys Met Glu Asn Gln Ile Leu Ile 
            20                  25                  30          


Lys Thr Val Phe Tyr Val His Arg Ile Arg Thr Gly Gly Lys Arg Tyr 
        35                  40                  45              


Val Ile Ile Leu Ala Ser Ile Ile Gln Leu Gln Trp Phe Glu Lys Ser 
    50                  55                  60                  


Ser Ser Thr 
65          


<210>  6591
<211>  2255
<212>  DNA
<213>  Homosapiens

<400>  6591
ccggcgtctt agcccgctct tctggccccg ccccgcgcta cgcgtaggga ggcggggcct     60

cggggcgaga cgccggagcg tgtccccgtc cggcagacta ctctccccca tggcggactt    120

cgctgggccg tcttctgccg gccgcaaggc cggggctccc cgctgctctc gaaaagccgc    180

aggtactaaa cagacaagta ctttgaaaca agaagatgct tctaaaagga aagctgaact    240

agaagcagct gtgagaaaga agattgaatt tgagagaaaa gctctacata ttgttgaaca    300

gcttttagag gagaatatta cagaagagtt cctaatggag tgtgggaggt tcattacacc    360

tgctcactac agtgatgtcg tggatgaacg ttctattgtc aaactctgtg gttatccttt    420

atgtcagaag aagctgggaa ttgtaccaaa acagaaatat aaaatttcta ccaaaaccaa    480

taaagtctat gatattactg aaagaaagtc tttttgcagc aatttttgtt atcaagcatc    540

taagtttttt gaagcacaaa ttcccaaaac tccagtatgg gttcgagaag aagagaggca    600

tcctgatttt caactgctaa aggaagaaca aagtggccat tctggagaag aagtacagtt    660

atgcagtaaa gccattaaaa catcagatat cgacaatcct agccactttg aaaagcaata    720

tgaatctagt tcttctagca ctcacagtga tagtagcagt gacaatgagc aagactttgt    780

ttcctccatt ctaccaggaa acagaccaaa ttcaacaaat attagaccac agctgcacca    840

aaaaagcata atgaaaaaga aagctggtca caaagctaac tccaaacaca aagacaaaga    900

acagacagta gtagatgtca ctgagcagtt aggcgattgc aaattagata gtcaggagaa    960

agatgctaca tgtgaacttc ctttacagaa agtaaatact cagagttctt caaatagcac   1020

tttgcctgaa agattaaaag cgtcagaaaa ttctgaaagt gaatacagta ggtcagaaat   1080

aactctagta ggcataagta agaaaagtgc agagcatttt aagagaaaat ttgccaaatc   1140

aaaccaagtg tctaggtcag tgtctagttc agtgcaggtg tgtcctgaag ttggaaagag   1200

aaacttactt aaagttttga aggagacttt gattgagtgg aagacagaag aaacattgag   1260

gtttttgtat ggccagaatt atgcttctgt gtgtctgaaa cccgaagcct ctctggttaa   1320

agaagaactt gatgaagatg acataatctc agatccagat agtcatttcc ctgcctggag   1380

ggaatctcag aacagcttgg atgagtcttt accttttagg ggctcaggta cagccattaa   1440

accactgcca agttacgaga atttgaaaaa agaaactgaa aagttaaatc tgaggatcag   1500

ggagttttac agaggacggt atgttttggg tgaagaaacc accaaatcac aagactcaga   1560

agagcatgat tccacctttc cactgataga ctcaagttcc cagaaccaga ttagaaaacg   1620

catcgtactt gaaaagttga gtaaagtgtt gcctgggctt ctggttcctc ttcagattac   1680

attgggagat atttacacac aacttaaaaa tcttgttcga actttcaggt taacaaatag   1740

aaatattata cacaaacctg cggaatggac tttaattgct atggtgttgc tgtcattact   1800

gaccccaatt cttggcattc agaaacattc tcaggaaggt atggtgttta cacggtttct   1860

agacaccctc cttgaagaat tacatctaaa aaatgaagac cttgaaagtc taaccatcat   1920

atttagaacc agctgtttac cagagtgata tattccatga agacaaaata gaagatgaac   1980

ttctattcac cgtttctgga attctagccg ccatgatggt ctggtggtga ctgataacta   2040

gttttattcc aagacatacc tttacctctt taagtttcaa tctcccatct cccagtcctt   2100

cagtccccaa ctgcagagga tgacctcccc agatagagga gaatcattac tccaacaaga   2160

ataaccaagt ctttgtatcc ctagtacaag acatagtatt tttattcgaa aatgaatgtt   2220

taagtattaa attgaaactt gaatgaatat tcaag                              2255


<210>  6592
<211>  612
<212>  PRT
<213>  Homosapiens

<400>  6592

Met Ala Asp Phe Ala Gly Pro Ser Ser Ala Gly Arg Lys Ala Gly Ala 
1               5                   10                  15      


Pro Arg Cys Ser Arg Lys Ala Ala Gly Thr Lys Gln Thr Ser Thr Leu 
            20                  25                  30          


Lys Gln Glu Asp Ala Ser Lys Arg Lys Ala Glu Leu Glu Ala Ala Val 
        35                  40                  45              


Arg Lys Lys Ile Glu Phe Glu Arg Lys Ala Leu His Ile Val Glu Gln 
    50                  55                  60                  


Leu Leu Glu Glu Asn Ile Thr Glu Glu Phe Leu Met Glu Cys Gly Arg 
65                  70                  75                  80  


Phe Ile Thr Pro Ala His Tyr Ser Asp Val Val Asp Glu Arg Ser Ile 
                85                  90                  95      


Val Lys Leu Cys Gly Tyr Pro Leu Cys Gln Lys Lys Leu Gly Ile Val 
            100                 105                 110         


Pro Lys Gln Lys Tyr Lys Ile Ser Thr Lys Thr Asn Lys Val Tyr Asp 
        115                 120                 125             


Ile Thr Glu Arg Lys Ser Phe Cys Ser Asn Phe Cys Tyr Gln Ala Ser 
    130                 135                 140                 


Lys Phe Phe Glu Ala Gln Ile Pro Lys Thr Pro Val Trp Val Arg Glu 
145                 150                 155                 160 


Glu Glu Arg His Pro Asp Phe Gln Leu Leu Lys Glu Glu Gln Ser Gly 
                165                 170                 175     


His Ser Gly Glu Glu Val Gln Leu Cys Ser Lys Ala Ile Lys Thr Ser 
            180                 185                 190         


Asp Ile Asp Asn Pro Ser His Phe Glu Lys Gln Tyr Glu Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr His Ser Asp Ser Ser Ser Asp Asn Glu Gln Asp Phe Val 
    210                 215                 220                 


Ser Ser Ile Leu Pro Gly Asn Arg Pro Asn Ser Thr Asn Ile Arg Pro 
225                 230                 235                 240 


Gln Leu His Gln Lys Ser Ile Met Lys Lys Lys Ala Gly His Lys Ala 
                245                 250                 255     


Asn Ser Lys His Lys Asp Lys Glu Gln Thr Val Val Asp Val Thr Glu 
            260                 265                 270         


Gln Leu Gly Asp Cys Lys Leu Asp Ser Gln Glu Lys Asp Ala Thr Cys 
        275                 280                 285             


Glu Leu Pro Leu Gln Lys Val Asn Thr Gln Ser Ser Ser Asn Ser Thr 
    290                 295                 300                 


Leu Pro Glu Arg Leu Lys Ala Ser Glu Asn Ser Glu Ser Glu Tyr Ser 
305                 310                 315                 320 


Arg Ser Glu Ile Thr Leu Val Gly Ile Ser Lys Lys Ser Ala Glu His 
                325                 330                 335     


Phe Lys Arg Lys Phe Ala Lys Ser Asn Gln Val Ser Arg Ser Val Ser 
            340                 345                 350         


Ser Ser Val Gln Val Cys Pro Glu Val Gly Lys Arg Asn Leu Leu Lys 
        355                 360                 365             


Val Leu Lys Glu Thr Leu Ile Glu Trp Lys Thr Glu Glu Thr Leu Arg 
    370                 375                 380                 


Phe Leu Tyr Gly Gln Asn Tyr Ala Ser Val Cys Leu Lys Pro Glu Ala 
385                 390                 395                 400 


Ser Leu Val Lys Glu Glu Leu Asp Glu Asp Asp Ile Ile Ser Asp Pro 
                405                 410                 415     


Asp Ser His Phe Pro Ala Trp Arg Glu Ser Gln Asn Ser Leu Asp Glu 
            420                 425                 430         


Ser Leu Pro Phe Arg Gly Ser Gly Thr Ala Ile Lys Pro Leu Pro Ser 
        435                 440                 445             


Tyr Glu Asn Leu Lys Lys Glu Thr Glu Lys Leu Asn Leu Arg Ile Arg 
    450                 455                 460                 


Glu Phe Tyr Arg Gly Arg Tyr Val Leu Gly Glu Glu Thr Thr Lys Ser 
465                 470                 475                 480 


Gln Asp Ser Glu Glu His Asp Ser Thr Phe Pro Leu Ile Asp Ser Ser 
                485                 490                 495     


Ser Gln Asn Gln Ile Arg Lys Arg Ile Val Leu Glu Lys Leu Ser Lys 
            500                 505                 510         


Val Leu Pro Gly Leu Leu Val Pro Leu Gln Ile Thr Leu Gly Asp Ile 
        515                 520                 525             


Tyr Thr Gln Leu Lys Asn Leu Val Arg Thr Phe Arg Leu Thr Asn Arg 
    530                 535                 540                 


Asn Ile Ile His Lys Pro Ala Glu Trp Thr Leu Ile Ala Met Val Leu 
545                 550                 555                 560 


Leu Ser Leu Leu Thr Pro Ile Leu Gly Ile Gln Lys His Ser Gln Glu 
                565                 570                 575     


Gly Met Val Phe Thr Arg Phe Leu Asp Thr Leu Leu Glu Glu Leu His 
            580                 585                 590         


Leu Lys Asn Glu Asp Leu Glu Ser Leu Thr Ile Ile Phe Arg Thr Ser 
        595                 600                 605             


Cys Leu Pro Glu 
    610         


<210>  6593
<211>  2317
<212>  DNA
<213>  Homosapiens

<400>  6593
ccggcgtctt agcccgctct tctggccccg ccccgcgcta cgcgtaggga ggcggggcct     60

cggggcgaga cgccggagcg tgtccccgtc cggcagacta ctctccccca tggcggactt    120

cgctgggccg tcttctgccg gccgcaaggc cggggctccc cgctgctctc gaaaagccgc    180

aggtactaaa cagacaagta ctttgaaaca agaagatgct tctaaaagga aagctgaact    240

agaagcagct gtgagaaaga agattgaatt tgagagaaaa gctctacata ttgttgaaca    300

gcttttagag gagaatatta cagaagagtt cctaatggag tgtgggaggt tcattacacc    360

tgctcactac agtgatgtcg tggatgaacg ttctattgtc aaactctgtg gttatccttt    420

atgtcagaag aagctgggaa ttgtaccaaa acagaaatat aaaatttcta ccaaaaccaa    480

taaagtctat gatattactg aaagaaagtc tttttgcagc aatttttgtt atcaagcatc    540

taagtttttt gaagcacaaa ttcccaaaac tccagtatgg gttcgagaag aagagaggca    600

tcctgatttt caactgctaa aggaagaaca aagtggccat tctggagaag aagtacagtt    660

atgcagtaaa gccattaaaa catcagatat cgacaatcct agccactttg aaaagcaata    720

tgaatctagt tcttctagca ctcacagtga tagtagcagt gacaatgagc aagactttgt    780

ttcctccatt ctaccaggaa acagaccaaa ttcaacaaat attagaccac agctgcacca    840

aaaaagcata atgaaaaaga aagctggtca caaagctaac tccaaacaca aagacaaaga    900

acagacagta gtagatgtca ctgagcagtt aggcgattgc aaattagata gtcaggagaa    960

agatgctaca tgtgaacttc ctttacagaa agtaaatact cagagttctt caaatagcac   1020

tttgcctgaa agattaaaag cgtcagaaaa ttctgaaagt gaatacagta ggtcagaaat   1080

aactctagta ggcataagta agaaaagtgc agagcatttt aagagaaaat ttgccaaatc   1140

aaaccaagtg tctaggtcag tgtctagttc agtgcaggtg tgtcctgaag ttggaaagag   1200

aaacttactt aaagttttga aggagacttt gattgagtgg aagacagaag aaacattgag   1260

gtttttgtat ggccagaatt atgcttctgt gtgtctgaaa cccgaagcct ctctggttaa   1320

agaagaactt gatgaagatg acataatctc agatccagat agtcatttcc ctgcctggag   1380

ggaatctcag aacagcttgg atgagtcttt accttttagg ggctcaggta cagccattaa   1440

accactgcca agttacgaga atttgaaaaa agaaactgaa aagttaaatc tgaggatcag   1500

ggagttttac agaggacggt atgttttggg tgaagaaacc accaaatcac aagactcaga   1560

agagcatgat tccacctttc cactgataga ctcaagttcc cagaaccaga ttagaaaacg   1620

catcgtactt gaaaagttga gtaaagtgtt gcctgggctt ctggttcctc ttcagattac   1680

attgggagat atttacacac aacttaaaaa tcttgttcga actttcaggt taacaaatag   1740

aaatattata cacaaacctg cggaatggac tttaattgct atggtgttgc tgtcattcct   1800

actcaatgtg aagacaagga taaagacctt tatgatgatc tacttccact taatgaataa   1860

ctgaccccaa ttcttggcat tcagaaacat tctcaggaag gtatggtgtt tacacggttt   1920

ctagacaccc tccttgaaga attacatcta aaaaatgaag accttgaaag tctaaccatc   1980

atatttagaa ccagctgttt accagagtga tatattccat gaagacaaaa tagaagatga   2040

acttctattc accgtttctg gaattctagc cgccatgatg gtctggtggt gactgataac   2100

tagttttatt ccaagacata cctttacctc tttaagtttc aatctcccat ctcccagtcc   2160

ttcagtcccc aactgcagag gatgacctcc ccagatagag gagaatcatt actccaacaa   2220

gaataaccaa gtctttgtat ccctagtaca agacatagta tttttattcg aaaatgaatg   2280

tttaagtatt aaattgaaac ttgaatgaat attcaag                            2317


<210>  6594
<211>  584
<212>  PRT
<213>  Homosapiens

<400>  6594

Met Ala Asp Phe Ala Gly Pro Ser Ser Ala Gly Arg Lys Ala Gly Ala 
1               5                   10                  15      


Pro Arg Cys Ser Arg Lys Ala Ala Gly Thr Lys Gln Thr Ser Thr Leu 
            20                  25                  30          


Lys Gln Glu Asp Ala Ser Lys Arg Lys Ala Glu Leu Glu Ala Ala Val 
        35                  40                  45              


Arg Lys Lys Ile Glu Phe Glu Arg Lys Ala Leu His Ile Val Glu Gln 
    50                  55                  60                  


Leu Leu Glu Glu Asn Ile Thr Glu Glu Phe Leu Met Glu Cys Gly Arg 
65                  70                  75                  80  


Phe Ile Thr Pro Ala His Tyr Ser Asp Val Val Asp Glu Arg Ser Ile 
                85                  90                  95      


Val Lys Leu Cys Gly Tyr Pro Leu Cys Gln Lys Lys Leu Gly Ile Val 
            100                 105                 110         


Pro Lys Gln Lys Tyr Lys Ile Ser Thr Lys Thr Asn Lys Val Tyr Asp 
        115                 120                 125             


Ile Thr Glu Arg Lys Ser Phe Cys Ser Asn Phe Cys Tyr Gln Ala Ser 
    130                 135                 140                 


Lys Phe Phe Glu Ala Gln Ile Pro Lys Thr Pro Val Trp Val Arg Glu 
145                 150                 155                 160 


Glu Glu Arg His Pro Asp Phe Gln Leu Leu Lys Glu Glu Gln Ser Gly 
                165                 170                 175     


His Ser Gly Glu Glu Val Gln Leu Cys Ser Lys Ala Ile Lys Thr Ser 
            180                 185                 190         


Asp Ile Asp Asn Pro Ser His Phe Glu Lys Gln Tyr Glu Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr His Ser Asp Ser Ser Ser Asp Asn Glu Gln Asp Phe Val 
    210                 215                 220                 


Ser Ser Ile Leu Pro Gly Asn Arg Pro Asn Ser Thr Asn Ile Arg Pro 
225                 230                 235                 240 


Gln Leu His Gln Lys Ser Ile Met Lys Lys Lys Ala Gly His Lys Ala 
                245                 250                 255     


Asn Ser Lys His Lys Asp Lys Glu Gln Thr Val Val Asp Val Thr Glu 
            260                 265                 270         


Gln Leu Gly Asp Cys Lys Leu Asp Ser Gln Glu Lys Asp Ala Thr Cys 
        275                 280                 285             


Glu Leu Pro Leu Gln Lys Val Asn Thr Gln Ser Ser Ser Asn Ser Thr 
    290                 295                 300                 


Leu Pro Glu Arg Leu Lys Ala Ser Glu Asn Ser Glu Ser Glu Tyr Ser 
305                 310                 315                 320 


Arg Ser Glu Ile Thr Leu Val Gly Ile Ser Lys Lys Ser Ala Glu His 
                325                 330                 335     


Phe Lys Arg Lys Phe Ala Lys Ser Asn Gln Val Ser Arg Ser Val Ser 
            340                 345                 350         


Ser Ser Val Gln Val Cys Pro Glu Val Gly Lys Arg Asn Leu Leu Lys 
        355                 360                 365             


Val Leu Lys Glu Thr Leu Ile Glu Trp Lys Thr Glu Glu Thr Leu Arg 
    370                 375                 380                 


Phe Leu Tyr Gly Gln Asn Tyr Ala Ser Val Cys Leu Lys Pro Glu Ala 
385                 390                 395                 400 


Ser Leu Val Lys Glu Glu Leu Asp Glu Asp Asp Ile Ile Ser Asp Pro 
                405                 410                 415     


Asp Ser His Phe Pro Ala Trp Arg Glu Ser Gln Asn Ser Leu Asp Glu 
            420                 425                 430         


Ser Leu Pro Phe Arg Gly Ser Gly Thr Ala Ile Lys Pro Leu Pro Ser 
        435                 440                 445             


Tyr Glu Asn Leu Lys Lys Glu Thr Glu Lys Leu Asn Leu Arg Ile Arg 
    450                 455                 460                 


Glu Phe Tyr Arg Gly Arg Tyr Val Leu Gly Glu Glu Thr Thr Lys Ser 
465                 470                 475                 480 


Gln Asp Ser Glu Glu His Asp Ser Thr Phe Pro Leu Ile Asp Ser Ser 
                485                 490                 495     


Ser Gln Asn Gln Ile Arg Lys Arg Ile Val Leu Glu Lys Leu Ser Lys 
            500                 505                 510         


Val Leu Pro Gly Leu Leu Val Pro Leu Gln Ile Thr Leu Gly Asp Ile 
        515                 520                 525             


Tyr Thr Gln Leu Lys Asn Leu Val Arg Thr Phe Arg Leu Thr Asn Arg 
    530                 535                 540                 


Asn Ile Ile His Lys Pro Ala Glu Trp Thr Leu Ile Ala Met Val Leu 
545                 550                 555                 560 


Leu Ser Phe Leu Leu Asn Val Lys Thr Arg Ile Lys Thr Phe Met Met 
                565                 570                 575     


Ile Tyr Phe His Leu Met Asn Asn 
            580                 


<210>  6595
<211>  3123
<212>  DNA
<213>  Homosapiens

<400>  6595
ccggcgtctt agcccgctct tctggccccg ccccgcgcta cgcgtaggga ggcggggcct     60

cggggcgaga cgccggagcg tgtccccgtc cggcagacta ctctccccca tggcggactt    120

cgctgggccg tcttctgccg gccgcaaggc cggggctccc cgctgctctc gaaaagccgc    180

aggtactaaa cagacaagta ctttgaaaca agaagatgct tctaaaagga aagctgaact    240

agaagcagct gtgagaaaga agattgaatt tgagagaaaa gctctacata ttgttgaaca    300

gcttttagag gagaatatta cagaagagtt cctaatggag tgtgggaggt tcattacacc    360

tgctcactac agtgatgtcg tggatgaacg ttctattgtc aaactctgtg gttatccttt    420

atgtcagaag aagctgggaa ttgtaccaaa acagaaatat aaaatttcta ccaaaaccaa    480

taaagtctat gatattactg aaagaaagtc tttttgcagc aatttttgtt atcaagcatc    540

taagtttttt gaagcacaaa ttcccaaaac tccagtatgg gttcgagaag aagagaggca    600

tcctgatttt caactgctaa aggaagaaca aagtggccat tctggagaag aagtacagtt    660

atgcagtaaa gccattaaaa catcagatat cgacaatcct agccactttg aaaagcaata    720

tgaatctagt tcttctagca ctcacagtga tagtagcagt gacaatgagc aagactttgt    780

ttcctccatt ctaccaggaa acagaccaaa ttcaacaaat attagaccac agctgcacca    840

aaaaagcata atgaaaaaga aagctggtca caaagctaac tccaaacaca aagacaaaga    900

acagacagta gtagatgtca ctgagcagtt aggcgattgc aaattagata gtcaggagaa    960

agatgctaca tgtgaacttc ctttacagaa agtaaatact cagagttctt caaatagcac   1020

tttgcctgaa agattaaaag cgtcagaaaa ttctgaaagt gaatacagta ggtcagaaat   1080

aactctagta ggcataagta agaaaagtgc agagcatttt aagagaaaat ttgccaaatc   1140

aaaccaagtg tctaggtcag tgtctagttc agtgcaggtg tgtcctgaag ttggaaagag   1200

aaacttactt aaagttttga aggagacttt gattgagtgg aagacagaag aaacattgag   1260

gtttttgtat ggccagaatt atgcttctgt gtgtctgaaa cccgaagcct ctctggttaa   1320

agaagaactt gatgaagatg acataatctc agatccagat agtcatttcc ctgcctggag   1380

ggaatctcag aacagcttgg atgagtcttt accttttagg ggctcaggta cagccattaa   1440

accactgcca agttacgaga atttgaaaaa agaaactgaa aagttaaatc tgaggatcag   1500

ggagttttac agaggacggt atgttttggg tgaagaaacc accaaatcac aagactcaga   1560

agagcatgat tccacctttc cactgataga ctcaagttcc cagaaccaga ttagaaaacg   1620

catcgtactt gaaaagttga gtaaagtgtt gcctgggctt ctggttcctc ttcagattac   1680

attgggagat atttacacac aacttaaaaa tcttgttcga actttcaggt taacaaatag   1740

aaatattata cacaaacctg cggaatggac tttaattgct atggtgttgc tgtcattact   1800

gaccccaatt cttggcattc agaaacattc tcaggaaggt atggtgttta cacggtttct   1860

agacaccctc cttgaagaat tacatctaaa aaatgaagac cttgaaagtc taaccatcat   1920

atttagaacc agctgtttac cagagtgata tattccatga agacaaaata gaagatgaac   1980

ttctattcac cgtttctgga attctagccg ccatgatggt ctggtggtga ctgataacta   2040

gttttattcc aagacatacc tttacctctt taagtttcaa tctcccatct cccagtcctt   2100

cagtccccaa ctgcagagga tgacctcccc agatagagga gaatcattac tccaacaaga   2160

ataaccaagt ctttgtatcc ctagtacaag acatagtatt tttattcgaa aatgaatgtt   2220

taagtattaa attgaaactt gaatgaatat tcaagaaaat ataatgatct ctactttttc   2280

tggatgattt ccagccatca tatcagtttg ccaaaaaaat tgagaaagtt atgattttga   2340

cctcccaacc taaactctaa attctaaaga tcagtaaaca attaggtcaa taaatacata   2400

caatttaaga tgaagccctt tggaagtcta gtccaaaaca ggaaaatctc agaactttct   2460

ggactcaagg aaatgcttta aatggaatct gtagtttgtt tgcaggagag acaatttcta   2520

gaatttagat tgcttttcaa aatgtttatc aggtaggcaa gttagcagtt gaggcggaac   2580

acagacaact tggggagctt tactggaagg ccaagaaaat actcttggac actggaggaa   2640

atgacagcta ctaaagccca atcatggaaa aggaccagaa agcagcccac tggaatgggg   2700

agcttagtgg gcaaggaggt agggatataa tttctcttct tggctccacc agtaattagc   2760

tctgtggccc agtcacctaa actttctgga cttcagttca ggttgtatgg cagtaggcca   2820

tagaattggc tactgccata caatctctat gggaaaggac tgcaaaaact aaattttatc   2880

tctgtatggg caaaggctac tgtcatcctg ttgttggtct ggggccactc tgacaatttt   2940

ttttaacctc atttgattgt gtaagggtct aaccacaaca aaaaatcata gtgtaataga   3000

attaatcaag ttcagcaagg tcacaggcta gatcaatata cagaaaatca attgtatttt   3060

tctgttcaga aaactccaaa aatgaaataa agaaaattgt gttcacaata tcaccaaaga   3120

gaa                                                                 3123


<210>  6596
<211>  612
<212>  PRT
<213>  Homosapiens

<400>  6596

Met Ala Asp Phe Ala Gly Pro Ser Ser Ala Gly Arg Lys Ala Gly Ala 
1               5                   10                  15      


Pro Arg Cys Ser Arg Lys Ala Ala Gly Thr Lys Gln Thr Ser Thr Leu 
            20                  25                  30          


Lys Gln Glu Asp Ala Ser Lys Arg Lys Ala Glu Leu Glu Ala Ala Val 
        35                  40                  45              


Arg Lys Lys Ile Glu Phe Glu Arg Lys Ala Leu His Ile Val Glu Gln 
    50                  55                  60                  


Leu Leu Glu Glu Asn Ile Thr Glu Glu Phe Leu Met Glu Cys Gly Arg 
65                  70                  75                  80  


Phe Ile Thr Pro Ala His Tyr Ser Asp Val Val Asp Glu Arg Ser Ile 
                85                  90                  95      


Val Lys Leu Cys Gly Tyr Pro Leu Cys Gln Lys Lys Leu Gly Ile Val 
            100                 105                 110         


Pro Lys Gln Lys Tyr Lys Ile Ser Thr Lys Thr Asn Lys Val Tyr Asp 
        115                 120                 125             


Ile Thr Glu Arg Lys Ser Phe Cys Ser Asn Phe Cys Tyr Gln Ala Ser 
    130                 135                 140                 


Lys Phe Phe Glu Ala Gln Ile Pro Lys Thr Pro Val Trp Val Arg Glu 
145                 150                 155                 160 


Glu Glu Arg His Pro Asp Phe Gln Leu Leu Lys Glu Glu Gln Ser Gly 
                165                 170                 175     


His Ser Gly Glu Glu Val Gln Leu Cys Ser Lys Ala Ile Lys Thr Ser 
            180                 185                 190         


Asp Ile Asp Asn Pro Ser His Phe Glu Lys Gln Tyr Glu Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr His Ser Asp Ser Ser Ser Asp Asn Glu Gln Asp Phe Val 
    210                 215                 220                 


Ser Ser Ile Leu Pro Gly Asn Arg Pro Asn Ser Thr Asn Ile Arg Pro 
225                 230                 235                 240 


Gln Leu His Gln Lys Ser Ile Met Lys Lys Lys Ala Gly His Lys Ala 
                245                 250                 255     


Asn Ser Lys His Lys Asp Lys Glu Gln Thr Val Val Asp Val Thr Glu 
            260                 265                 270         


Gln Leu Gly Asp Cys Lys Leu Asp Ser Gln Glu Lys Asp Ala Thr Cys 
        275                 280                 285             


Glu Leu Pro Leu Gln Lys Val Asn Thr Gln Ser Ser Ser Asn Ser Thr 
    290                 295                 300                 


Leu Pro Glu Arg Leu Lys Ala Ser Glu Asn Ser Glu Ser Glu Tyr Ser 
305                 310                 315                 320 


Arg Ser Glu Ile Thr Leu Val Gly Ile Ser Lys Lys Ser Ala Glu His 
                325                 330                 335     


Phe Lys Arg Lys Phe Ala Lys Ser Asn Gln Val Ser Arg Ser Val Ser 
            340                 345                 350         


Ser Ser Val Gln Val Cys Pro Glu Val Gly Lys Arg Asn Leu Leu Lys 
        355                 360                 365             


Val Leu Lys Glu Thr Leu Ile Glu Trp Lys Thr Glu Glu Thr Leu Arg 
    370                 375                 380                 


Phe Leu Tyr Gly Gln Asn Tyr Ala Ser Val Cys Leu Lys Pro Glu Ala 
385                 390                 395                 400 


Ser Leu Val Lys Glu Glu Leu Asp Glu Asp Asp Ile Ile Ser Asp Pro 
                405                 410                 415     


Asp Ser His Phe Pro Ala Trp Arg Glu Ser Gln Asn Ser Leu Asp Glu 
            420                 425                 430         


Ser Leu Pro Phe Arg Gly Ser Gly Thr Ala Ile Lys Pro Leu Pro Ser 
        435                 440                 445             


Tyr Glu Asn Leu Lys Lys Glu Thr Glu Lys Leu Asn Leu Arg Ile Arg 
    450                 455                 460                 


Glu Phe Tyr Arg Gly Arg Tyr Val Leu Gly Glu Glu Thr Thr Lys Ser 
465                 470                 475                 480 


Gln Asp Ser Glu Glu His Asp Ser Thr Phe Pro Leu Ile Asp Ser Ser 
                485                 490                 495     


Ser Gln Asn Gln Ile Arg Lys Arg Ile Val Leu Glu Lys Leu Ser Lys 
            500                 505                 510         


Val Leu Pro Gly Leu Leu Val Pro Leu Gln Ile Thr Leu Gly Asp Ile 
        515                 520                 525             


Tyr Thr Gln Leu Lys Asn Leu Val Arg Thr Phe Arg Leu Thr Asn Arg 
    530                 535                 540                 


Asn Ile Ile His Lys Pro Ala Glu Trp Thr Leu Ile Ala Met Val Leu 
545                 550                 555                 560 


Leu Ser Leu Leu Thr Pro Ile Leu Gly Ile Gln Lys His Ser Gln Glu 
                565                 570                 575     


Gly Met Val Phe Thr Arg Phe Leu Asp Thr Leu Leu Glu Glu Leu His 
            580                 585                 590         


Leu Lys Asn Glu Asp Leu Glu Ser Leu Thr Ile Ile Phe Arg Thr Ser 
        595                 600                 605             


Cys Leu Pro Glu 
    610         


<210>  6597
<211>  1954
<212>  DNA
<213>  Homosapiens

<400>  6597
cattaaaaca tcagatatcg acaatcctag ccactttgaa aagcaatatg aatctagttc     60

ttctagcact cacagtgata gtagcagtga caatgagcaa gactttgttt cctccattct    120

accaggaaac agaccaaatt caacaaatat tagaccacag ctgcaccaaa aaagcataat    180

gaaaaagaaa gctggtcaca aagctaactc caaacacaaa gacaaagaac agacagtagt    240

agatgtcact gagcagttag gcgattgcaa attagatagt caggagaaag atgctacatg    300

tgaacttcct ttacagaaag taaatactca gagttcttca aatagcactt tgcctgaaag    360

attaaaagcg tcagaaaatt ctgaaagtga atacagtagg tcagaaataa ctctagtagg    420

cataagtaag aaaagtgcag agcattttaa gagaaaattt gccaaatcaa accaagtgtc    480

taggtcagtg tctagttcag tgcaggtgtg tcctgaagtt ggaaagagaa acttacttaa    540

agttttgaag gagactttga ttgagtggaa gacagaagaa acattgaggt ttttgtatgg    600

ccagaattat gcttctgtgt gtctgaaacc cgaagcctct ctggttaaag aagaacttga    660

tgaagatgac ataatctcag atccagatag tcatttccct gcctggaggg aatctcagaa    720

cagcttggat gagtctttac cttttagggg ctcaggtaca gccattaaac cactgccaag    780

ttacgagaat ttgaaaaaag aaactgaaaa gttaaatctg aggatcaggg agttttacag    840

aggacggtat gttttgggtg actgataact agttttattc caagacatac ctttacctct    900

ttaagtttca atctcccatc tcccagtcct tcagtcccca actgcagagg atgacctccc    960

cagatagagg agaatcatta ctccaacaag aataaccaag tctttgtatc cctagtacaa   1020

gacatagtat ttttattcga aaatgaatgt ttaagtatta aattgaaact tgaatgaata   1080

ttcaagaaaa tataatgatc tctacttttt ctggatgatt tccagccatc atatcagttt   1140

gccaaaaaaa ttgagaaagt tatgattttg acctcccaac ctaaactcta aattctaaag   1200

atcagtaaac aattaggtca ataaatacat acaatttaag atgaagccct ttggaagtct   1260

agtccaaaac aggaaaatct cagaactttc tggactcaag gaaatgcttt aaatggaatc   1320

tgtagtttgt ttgcaggaga gacaatttct agaatttaga ttgcttttca aaatgtttat   1380

caggtaggca agttagcagt tgaggcggaa cacagacaac ttggggagct ttactggaag   1440

gccaagaaaa tactcttgga cactggagga aatgacagct actaaagccc aatcatggaa   1500

aaggaccaga aagcagccca ctggaatggg gagcttagtg ggcaaggagg tagggatata   1560

atttctcttc ttggctccac cagtaattag ctctgtggcc cagtcaccta aactttctgg   1620

acttcagttc aggttgtatg gcagtaggcc atagaattgg ctactgccat acaatctcta   1680

tgggaaagga ctgcaaaaac taaattttat ctctgtatgg gcaaaggcta ctgtcatcct   1740

gttgttggtc tggggccact ctgacaattt tttttaacct catttgattg tgtaagggtc   1800

taaccacaac aaaaaatcat agtgtaatag aattaatcaa gttcagcaag gtcacaggct   1860

agatcaatat acagaaaatc aattgtattt ttctgttcag aaaactccaa aaatgaaata   1920

aagaaaattg tgttcacaat atcaccaaag agaa                               1954


<210>  6598
<211>  228
<212>  PRT
<213>  Homosapiens

<400>  6598

Met Lys Lys Lys Ala Gly His Lys Ala Asn Ser Lys His Lys Asp Lys 
1               5                   10                  15      


Glu Gln Thr Val Val Asp Val Thr Glu Gln Leu Gly Asp Cys Lys Leu 
            20                  25                  30          


Asp Ser Gln Glu Lys Asp Ala Thr Cys Glu Leu Pro Leu Gln Lys Val 
        35                  40                  45              


Asn Thr Gln Ser Ser Ser Asn Ser Thr Leu Pro Glu Arg Leu Lys Ala 
    50                  55                  60                  


Ser Glu Asn Ser Glu Ser Glu Tyr Ser Arg Ser Glu Ile Thr Leu Val 
65                  70                  75                  80  


Gly Ile Ser Lys Lys Ser Ala Glu His Phe Lys Arg Lys Phe Ala Lys 
                85                  90                  95      


Ser Asn Gln Val Ser Arg Ser Val Ser Ser Ser Val Gln Val Cys Pro 
            100                 105                 110         


Glu Val Gly Lys Arg Asn Leu Leu Lys Val Leu Lys Glu Thr Leu Ile 
        115                 120                 125             


Glu Trp Lys Thr Glu Glu Thr Leu Arg Phe Leu Tyr Gly Gln Asn Tyr 
    130                 135                 140                 


Ala Ser Val Cys Leu Lys Pro Glu Ala Ser Leu Val Lys Glu Glu Leu 
145                 150                 155                 160 


Asp Glu Asp Asp Ile Ile Ser Asp Pro Asp Ser His Phe Pro Ala Trp 
                165                 170                 175     


Arg Glu Ser Gln Asn Ser Leu Asp Glu Ser Leu Pro Phe Arg Gly Ser 
            180                 185                 190         


Gly Thr Ala Ile Lys Pro Leu Pro Ser Tyr Glu Asn Leu Lys Lys Glu 
        195                 200                 205             


Thr Glu Lys Leu Asn Leu Arg Ile Arg Glu Phe Tyr Arg Gly Arg Tyr 
    210                 215                 220                 


Val Leu Gly Asp 
225             


<210>  6599
<211>  840
<212>  DNA
<213>  Homosapiens

<400>  6599
ctcaaattta aatctaattc tcaagtctag ttattttcct actgtgccac agatacaaac     60

ttttgtgttt taatgtttat tgttctgctt atcaaagaaa gaatgtaaac ttatgattct    120

gttttgcttt gtttaaaaat gtgattcagc atgattccac ctttccactg atagactcaa    180

gttcccagaa ccagattaga aaacgcatcg tacttgaaaa gttgagtaaa gtgttgcctg    240

ggcttctggt tcctcttcag attacattgg gagatattta cacacaactt aaaaatcttg    300

ttcgaacttt caggttaaca aatagaaata ttatacacaa acctgcggaa tggactttaa    360

ttgctatggt gttgctgtca ttactgaccc caattcttgg cattcagaaa cattctcagg    420

aaggtatggt gtttacacgg tttctagaca ccctccttga agaattacat ctaaaaaatg    480

aagaccttga aagtctaacc atcatattta gaaccagctg tttaccagag tgatatattc    540

catgaagaca aaatagaaga tgaacttcta ttcaccgttt ctggaattct agccgccatg    600

atggtctggt ggtgactgat aactagtttt attccaagac atacctttac ctctttaagt    660

ttcaatctcc catctcccag tccttcagtc cccaactgca gaggatgacc tccccagata    720

gaggagaatc attactccaa caagaataac caagtctttg tatccctagt acaagacata    780

gtatttttat tcgaaaatga atgtttaagt attaaattga aacttgaatg aatattcaag    840


<210>  6600
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  6600

Met Val Leu Leu Ser Leu Leu Thr Pro Ile Leu Gly Ile Gln Lys His 
1               5                   10                  15      


Ser Gln Glu Gly Met Val Phe Thr Arg Phe Leu Asp Thr Leu Leu Glu 
            20                  25                  30          


Glu Leu His Leu Lys Asn Glu Asp Leu Glu Ser Leu Thr Ile Ile Phe 
        35                  40                  45              


Arg Thr Ser Cys Leu Pro Glu 
    50                  55  


<210>  6601
<211>  1708
<212>  DNA
<213>  Homosapiens

<400>  6601
ctcaaattta aatctaattc tcaagtctag ttattttcct actgtgccac agatacaaac     60

ttttgtgttt taatgtttat tgttctgctt atcaaagaaa gaatgtaaac ttatgattct    120

gttttgcttt gtttaaaaat gtgattcagc atgattccac ctttccactg atagactcaa    180

gttcccagaa ccagattaga aaacgcatcg tacttgaaaa gttgagtaaa gtgttgcctg    240

ggcttctggt tcctcttcag attacattgg gagatattta cacacaactt aaaaatcttg    300

ttcgaacttt caggttaaca aatagaaata ttatacacaa acctgcggaa tggactttaa    360

ttgctatggt gttgctgtca ttactgaccc caattcttgg cattcagaaa cattctcagg    420

aaggtatggt gtttacacgg tttctagaca ccctccttga agaattacat ctaaaaaatg    480

aagaccttga aagtctaacc atcatattta gaaccagctg tttaccagag tgatatattc    540

catgaagaca aaatagaaga tgaacttcta ttcaccgttt ctggaattct agccgccatg    600

atggtctggt ggtgactgat aactagtttt attccaagac atacctttac ctctttaagt    660

ttcaatctcc catctcccag tccttcagtc cccaactgca gaggatgacc tccccagata    720

gaggagaatc attactccaa caagaataac caagtctttg tatccctagt acaagacata    780

gtatttttat tcgaaaatga atgtttaagt attaaattga aacttgaatg aatattcaag    840

aaaatataat gatctctact ttttctggat gatttccagc catcatatca gtttgccaaa    900

aaaattgaga aagttatgat tttgacctcc caacctaaac tctaaattct aaagatcagt    960

aaacaattag gtcaataaat acatacaatt taagatgaag ccctttggaa gtctagtcca   1020

aaacaggaaa atctcagaac tttctggact caaggaaatg ctttaaatgg aatctgtagt   1080

ttgtttgcag gagagacaat ttctagaatt tagattgctt ttcaaaatgt ttatcaggta   1140

ggcaagttag cagttgaggc ggaacacaga caacttgggg agctttactg gaaggccaag   1200

aaaatactct tggacactgg aggaaatgac agctactaaa gcccaatcat ggaaaaggac   1260

cagaaagcag cccactggaa tggggagctt agtgggcaag gaggtaggga tataatttct   1320

cttcttggct ccaccagtaa ttagctctgt ggcccagtca cctaaacttt ctggacttca   1380

gttcaggttg tatggcagta ggccatagaa ttggctactg ccatacaatc tctatgggaa   1440

aggactgcaa aaactaaatt ttatctctgt atgggcaaag gctactgtca tcctgttgtt   1500

ggtctggggc cactctgaca atttttttta acctcatttg attgtgtaag ggtctaacca   1560

caacaaaaaa tcatagtgta atagaattaa tcaagttcag caaggtcaca ggctagatca   1620

atatacagaa aatcaattgt atttttctgt tcagaaaact ccaaaaatga aataaagaaa   1680

attgtgttca caatatcacc aaagagaa                                      1708


<210>  6602
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  6602

Met Val Leu Leu Ser Leu Leu Thr Pro Ile Leu Gly Ile Gln Lys His 
1               5                   10                  15      


Ser Gln Glu Gly Met Val Phe Thr Arg Phe Leu Asp Thr Leu Leu Glu 
            20                  25                  30          


Glu Leu His Leu Lys Asn Glu Asp Leu Glu Ser Leu Thr Ile Ile Phe 
        35                  40                  45              


Arg Thr Ser Cys Leu Pro Glu 
    50                  55  


<210>  6603
<211>  1382
<212>  DNA
<213>  Homosapiens

<400>  6603
gctggcactg gacggagtag ggaaccctag ccgttatccc accaaagggt cccagcgcct     60

agaggggctg cggaaagctc ctacaatacg aggagccctt ggagcccaga gcgggatcct    120

gcgagccgag gccccgttct ctgttaggat cacggggact gccccaggca gctgctgggc    180

ccggtcgcgg acctcggcca gaacatcctc ccagaacaca gaggaatctg acatcagtgg    240

cctcccttgg tagaggtggg gagccgaggg gcggcagtgt ggaagggcca tcggcctagg    300

tctttcgtat cccctccggc ctctcggggc tgtgcgttcg gaaacagcga aaggaacggc    360

ctcaggaatc tggcctcagc cggagcactg gtgaacacag gctcccgtcg cgccaaggga    420

agtaggaaaa gctgcttccg ggcggagggg ctgcacttcc ggggcccgcg tcccccggcg    480

gcttcgccga gaaggggctt tgggagctta agggcgccgg cacgcgttcc cctggcgcag    540

agctcgctag ccggggcgcg ggctgcctcc ttgttctggt gtgatccgaa tgtaacggag    600

cggactttgg gatccagaac cccggactga ggttgtgctt ggcttgaggg gcgggctgga    660

tttttcctct taggatttat ttccctggag acctcatgaa gaatgatgtg ggttctatag    720

ggtacagtgt gatctgggtc ctgcctaatc tcctttctaa acttcagaaa atcatgtacc    780

ttggagttgt ggaggcatgt ttataagcag atctgagttt tgccacactg gaatttattt    840

attcattgaa caaatattta atacctacta caattcttag ccgatatatc agcacaactt    900

ctctgctcca actagtctac attgcaaagc atctcctagt gtctttggaa gaaggatcta    960

tggtgttata tgtgaacaaa gatgtagact agtaaggtat caagatttga tggggatatc   1020

cagacaactt ggagccaagt ccccacagct ggatcagaca acttttggtg acatctcaca   1080

gtgtggatta tcaagccagt gtatcagtct ggagcctagg ttttttgcct ttagctttgc   1140

tcaggatgac ttctgctctt ctatggcaat acttgagaag ctacagcttt gattagacga   1200

gaggctattt caataacttt ctcctgataa gaagaccacc gaccgtggac ggattctggc   1260

cagtttacaa aggctgcata ccatagggca gggcacccca ctatggcaaa cactaataat   1320

gatattgctc ctgattttgt ttctgaaggg aatgcctcta agatttcttc attaattata   1380

ag                                                                  1382


<210>  6604
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  6604

Met Gly Ile Ser Arg Gln Leu Gly Ala Lys Ser Pro Gln Leu Asp Gln 
1               5                   10                  15      


Thr Thr Phe Gly Asp Ile Ser Gln Cys Gly Leu Ser Ser Gln Cys Ile 
            20                  25                  30          


Ser Leu Glu Pro Arg Phe Phe Ala Phe Ser Phe Ala Gln Asp Asp Phe 
        35                  40                  45              


Cys Ser Ser Met Ala Ile Leu Glu Lys Leu Gln Leu 
    50                  55                  60  


<210>  6605
<211>  3191
<212>  DNA
<213>  Homosapiens

<400>  6605
agggtcgcgt caccatgaag cttcctctcg ggccgacagc tctagacact cgcaggtggg     60

ccagggacaa tcatcagggc ccaggacaag caggaaccag ggatccagtg ttagccagga    120

cagtgacagt cagggacact cagaagactc tgagaggtgg tctgggtctg cttccagaaa    180

ccatcttgga tctgcttggg agcagtcaag agatggctcc agacaccctg ggtcccatca    240

cgaagacaga gccggtcacg ggcactctgc agacagctcc agacaatcag gcactcgtca    300

cacagagtct tcctctcgtg gacaggctgc gtcatcccat gaacaggcaa gatcaagtgc    360

aggagaaaga catggatccc accaccagct ccagtcagca gacagctcca gacactcagg    420

cattgggcat ggacaagctt catctgcagt cagagacagt ggacaccgag ggtacagtgg    480

tagtcaggcc agtgacagtg agggacattc agaagactca gacacacagt cagtgtcagc    540

acagggaaaa gctgggcccc atcagcagag ccacaaagag tccgcacgtg gccagtcagg    600

ggaaagtctg gacgttcagg gtctttcctc taccaggtga gcactcatga acagtctgag    660

tctgcccatg ggcggaccag gaccagcact ggacgaagac aaggatccca ccacgagcag    720

gcacgagaca gctccaggca ctcagcgtcc caagagggtc aggacaccat tcgtggacac    780

ccggggtcaa gcagaagagg aaggcaggga tcccactacg agcaatcggt agataggtct    840

ggacactcag ggtcccatca cagccacacc acatcccagg gaaggtctga tgcctcccgt    900

gggcagtcag gatccagaag tgccagcaga caaactcgta atgacgaaca atcaggagat    960

ggctccaggc actcatggtc gcatcaccat gaagcttcca ctcaggcgga cagctctaga   1020

cactcacagt ccggccaggg acaatcagcg gggcccagga caagcaggaa ccagggatcc   1080

agtgttagcc aggacagtga cagtcaggga cactcagaag actctgagag gtggtctggg   1140

tctgcttcca gaaaccatcg tggatctgct caggagcagt caagagatgg ctccagacac   1200

cccacgtccc atcacgaaga cagagccggt cacgggcact ctgcagagag ctccagacaa   1260

tcaggcactc atcatgcaga gaattcctct ggtggacagg ctgcatcatc ccatgaacag   1320

gcaagatcaa gtgcaggaga gagacatgga tcccaccacc agcagtcagc agacagctcc   1380

agacactcag gcattgggca cggacaagct tcatctgcag tcagagacag tggacaccga   1440

gggtccagtg gtagtcaggc cagtgacagt gagggacatt cagaagactc agacacacag   1500

tcagtgtcag cccacggaca ggctgggccc catcagcaga gccaccaaga gtccacacgt   1560

ggccggtcag caggaaggtc tggacgttca gggtctttcc tctaccaggt gagcactcat   1620

gaacagtctg agtctgccca tggacgggct gggcccagta ctggaggaag acaaggatcc   1680

cgccacgagc aggcacgaga cagctccagg cactcagcgt cccaagaggg tcaggacacc   1740

attcgtggac acccggggtc aaggagagga ggaagacagg gatcctacca cgagcaatcg   1800

gtagataggt ctggacactc agggtcccat cacagccaca ccacatccca gggaaggtct   1860

gatgcctccc atgggcagtc aggatccaga agtgcaagca gagaaacacg taatgaggaa   1920

cagtcaggag acggctccag gcactcaggg tcgcgtcacc atgaagcttc cactcaggct   1980

gacagctcta gacactcaca gtccggccag ggtgaatcag cggggtccag gagaagcagg   2040

cgccagggat ccagtgttag ccaggacagt gacagtgagg catacccaga ggactctgag   2100

aggcgatctg agtctgcttc cagaaaccat catggatctt ctcgggagca gtcaagagat   2160

ggctccagac accccggatc ctctcaccgc gatacagcca gtcatgtaca gtcttcacct   2220

gtacagtcag actctagtac cgctaaggaa catggtcact ttagtagtct ttcacaagat   2280

tctgcgtatc actcaggaat acagtcacgt ggcagtcctc acagttctag ttcttatcat   2340

tatcaatctg agggcactga aaggcaaaaa ggtcaatcag gtttagtttg gagacatggc   2400

agctatggta gtgcagatta tgattatggt gaatccgggt ttagacactc tcagcacgga   2460

agtgttagtt acaattccaa tcctgttgtt ttcaaggaaa gatctgatat ctgtaaagca   2520

agtgcgtttg gtaaagatca tccaaggtat tatgcaacgt atattaataa ggacccaggt   2580

ttatgtggcc attctagtga tatatcgaaa caactgggat ttagtcagtc acagagatac   2640

tattactatg agtaagaaat taatggcaaa ggaattaatc caagaataga agaatgaagc   2700

aagttcactt tcaatcaaga aacttcataa tactttcagg gaagttatct tttcctgtca   2760

atctgtttaa aatatgctat agtatttcat tagtttggtg gtagcttatt tttattgtgt   2820

aatgatcttt aaacgctata tttcagaaat attaaatgga agaaatcaat atcatggaga   2880

gctaacttta gaaaactagc tggagtattt taggagattc tgggtcaagt aatgttttat   2940

gtttttgaaa gtttaagttt tagacactcc ccaaatttct aaattaatct ttttcagaaa   3000

tatcgaagga gccaaaaata taaaacagtt ctgtatacca aagtggctat atcaacatca   3060

gggctagcac atctttctct attatccttc tattggaatt ctagtattct gtattcaaaa   3120

aatcatcttg gacataatta atattatagt aagctgcatc taaattaaaa ataaactatt   3180

catcatataa t                                                        3191


<210>  6606
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  6606

Met Lys Leu Pro Leu Gly Pro Thr Ala Leu Asp Thr Arg Arg Trp Ala 
1               5                   10                  15      


Arg Asp Asn His Gln Gly Pro Gly Gln Ala Gly Thr Arg Asp Pro Val 
            20                  25                  30          


Leu Ala Arg Thr Val Thr Val Arg Asp Thr Gln Lys Thr Leu Arg Gly 
        35                  40                  45              


Gly Leu Gly Leu Leu Pro Glu Thr Ile Leu Asp Leu Leu Gly Ser Ser 
    50                  55                  60                  


Gln Glu Met Ala Pro Asp Thr Leu Gly Pro Ile Thr Lys Thr Glu Pro 
65                  70                  75                  80  


Val Thr Gly Thr Leu Gln Thr Ala Pro Asp Asn Gln Ala Leu Val Thr 
                85                  90                  95      


Gln Ser Leu Pro Leu Val Asp Arg Leu Arg His Pro Met Asn Arg Gln 
            100                 105                 110         


Asp Gln Val Gln Glu Lys Asp Met Asp Pro Thr Thr Ser Ser Ser Gln 
        115                 120                 125             


Gln Thr Ala Pro Asp Thr Gln Ala Leu Gly Met Asp Lys Leu His Leu 
    130                 135                 140                 


Gln Ser Glu Thr Val Asp Thr Glu Gly Thr Val Val Val Arg Pro Val 
145                 150                 155                 160 


Thr Val Arg Asp Ile Gln Lys Thr Gln Thr His Ser Gln Cys Gln His 
                165                 170                 175     


Arg Glu Lys Leu Gly Pro Ile Ser Arg Ala Thr Lys Ser Pro His Val 
            180                 185                 190         


Ala Ser Gln Gly Lys Val Trp Thr Phe Arg Val Phe Pro Leu Pro Gly 
        195                 200                 205             


Glu His Ser 
    210     


<210>  6607
<211>  3191
<212>  DNA
<213>  Homosapiens

<400>  6607
agggtcgcgt caccatgaag cttcctctcg ggccgacagc tctagacact cgcaggtggg     60

ccagggacaa tcatcagggc ccaggacaag caggaaccag ggatccagtg ttagccagga    120

cagtgacagt cagggacact cagaagactc tgagaggtgg tctgggtctg cttccagaaa    180

ccatcttgga tctgcttggg agcagtcaag agatggctcc agacaccctg ggtcccatca    240

cgaagacaga gccggtcacg ggcactctgc agacagctcc agacaatcag gcactcgtca    300

cacagagtct tcctctcgtg gacaggctgc gtcatcccat gaacaggcaa gatcaagtgc    360

aggagaaaga catggatccc accaccagct ccagtcagca gacagctcca gacactcagg    420

cattgggcat ggacaagctt catctgcagt cagagacagt ggacaccgag ggtacagtgg    480

tagtcaggcc agtgacagtg agggacattc agaagactca gacacacagt cagtgtcagc    540

acagggaaaa gctgggcccc atcagcagag ccacaaagag tccgcacgtg gccagtcagg    600

ggaaagctct ggacgttcag ggtctttcct ctaccaggtg agcactcatg aacagtctga    660

gtccacccat ggacagtctg cgcccagcac tggaggaaga caaggatccc attatgatca    720

ggcacaagac agctccaggc actcagcatc ccaagagggt caggacacca ttcgtggaca    780

cccggggcca agcagaggag gaagacaggg gtcccaccaa gagcaatcgg tagataggtc    840

tggacactca gggtctcatc acagccacac cacatcccag ggaaggtctg atgcctcccg    900

tgggcagtca ggatccagaa gtgcaagcag aaaaacatat gacaaggaac aatcaggaga    960

tggctctagg cactcagggt cgcatcatca tgaagcttcc tcttgggccg acagctctag   1020

acactcaagt ccggccaggg acaatcagcg gggcccagga caagcaggaa ccagggatcc   1080

agtgttagcc aggacagtga cagtcaggga cactcagaag actctgagag gtggtctggg   1140

tctgcttcca gaaaccatcg tggatctgct caggagcagt caagagatgg ctccagacac   1200

cccacgtccc atcacgaaga cagagccggt cacgggcact ctgcagagag ctccagacaa   1260

tcaggcactc atcatgcaga gaattcctct ggtggacagg ctgcatcatc ccatgaacag   1320

gcaagatcaa gtgcaggaga gagacatgga tcccaccacc agcagtcagc agacagctcc   1380

agacactcag gcattgggca cggacaagct tcatctgcag tcagagacag tggacaccga   1440

gggtccagtg gtagtcaggc cagtgacagt gagggacatt cagaagactc agacacacag   1500

tcagtgtcag cccacggaca ggctgggccc catcagcaga gccaccaaga gtccacacgt   1560

ggccggtcag caggaaggtc tggacgttca gggtctttcc tctaccaggt gagcactcat   1620

gaacagtctg agtctgccca tggacgggct gggcccagta ctggaggaag acaaggatcc   1680

cgccacgagc aggcacgaga cagctccagg cactcagcgt cccaagaggg tcaggacacc   1740

attcgtggac acccggggtc aaggagagga ggaagacagg gatcctacca cgagcaatcg   1800

gtagataggt ctggacactc agggtcccat cacagccaca ccacatccca gggaaggtct   1860

gatgcctccc atgggcagtc aggatccaga agtgcaagca gagaaacacg taatgaggaa   1920

cagtcaggag acggctccag gcactcaggg tcgcgtcacc atgaagcttc cactcaggct   1980

gacagctcta gacactcaca gtccggccag ggtgaatcag cggggtccag gagaagcagg   2040

cgccagggat ccagtgttag ccaggacagt gacagtgagg catacccaga ggactctgag   2100

aggcgatctg agtctgcttc cagaaaccat catggatctt ctcgggagca gtcaagagat   2160

ggctccagac accccggatc ctctcaccgc gatacagcca gtcatgtaca gtcttcacct   2220

gtacagtcag actctagtac cgctaaggaa catggtcact ttagtagtct ttcacaagat   2280

tctgcgtatc actcaggaat acagtcacgt ggcagtcctc acagttctag ttcttatcat   2340

tatcaatctg agggcactga aaggcaaaaa ggtcaatcag gtttagtttg gagacatggc   2400

agctatggta gtgcagatta tgattatggt gaatccgggt ttagacactc tcagcacgga   2460

agtgttagtt acaattccaa tcctgttgtt ttcaaggaaa gatctgatat ctgtaaagca   2520

agtgcgtttg gtaaagatca tccaaggtat tatgcaacgt atattaataa ggacccaggt   2580

ttatgtggcc attctagtga tatatcgaaa caactgggat ttagtcagtc acagagatac   2640

tattactatg agtaagaaat taatggcaaa ggaattaatc caagaataga agaatgaagc   2700

aagttcactt tcaatcaaga aacttcataa tactttcagg gaagttatct tttcctgtca   2760

atctgtttaa aatatgctat agtatttcat tagtttggtg gtagcttatt tttattgtgt   2820

aatgatcttt aaacgctata tttcagaaat attaaatgga agaaatcaat atcatggaga   2880

gctaacttta gaaaactagc tggagtattt taggagattc tgggtcaagt aatgttttat   2940

gtttttgaaa gtttaagttt tagacactcc ccaaatttct aaattaatct ttttcagaaa   3000

tatcgaagga gccaaaaata taaaacagtt ctgtatacca aagtggctat atcaacatca   3060

gggctagcac atctttctct attatccttc tattggaatt ctagtattct gtattcaaaa   3120

aatcatcttg gacataatta atattatagt aagctgcatc taaattaaaa ataaactatt   3180

catcatataa t                                                        3191


<210>  6608
<211>  65
<212>  PRT
<213>  Homosapiens

<400>  6608

Met Pro Pro Val Gly Ser Gln Asp Pro Glu Val Gln Ala Glu Lys His 
1               5                   10                  15      


Met Thr Arg Asn Asn Gln Glu Met Ala Leu Gly Thr Gln Gly Arg Ile 
            20                  25                  30          


Ile Met Lys Leu Pro Leu Gly Pro Thr Ala Leu Asp Thr Gln Val Arg 
        35                  40                  45              


Pro Gly Thr Ile Ser Gly Ala Gln Asp Lys Gln Glu Pro Gly Ile Gln 
    50                  55                  60                  


Cys 
65  


<210>  6609
<211>  5060
<212>  DNA
<213>  Homosapiens

<400>  6609
aggttcacat ttattgccaa aagatgtcta ctctcctgga aaacatcttt gccataatta     60

atcttttcaa gcaatattca aaaaaagata aaaacactga cacattgagt aaaaaagagc    120

tgaaggaact tctggaaaag gaatttcggc aaatcctgaa gaatccagat gacccagata    180

tggttgatgt cttcatggat cacttggata tagaccacaa caagaaaatt gacttcactg    240

agtttcttct gatggtattc aagttggctc aagcatatta tgagtctacc agaaaagaga    300

atttaccgat atcaggacac aagcacagaa agcacagtca tcatgataaa catgaagata    360

ataaacagga agaaaacaaa gaaaacagaa aaagaccctc aagtctggaa agaagaaaca    420

atagaaaagg gaataaggga agatccaaga gcccaagaga aacagggggg aaaaggcatg    480

aatctagttc tgaaaaaaaa gaaagaaaag gatattcacc tactcataga gaagaagaat    540

atggaaaaaa ccatcataac tcaagtaaaa aagagaaaaa caagactgaa aatactagat    600

taggagacaa taggaagagg ctaagtgaaa gacttgaaga gaaagaagac aatgaagaag    660

gagtatatga ttatgaaaat acaggaagaa tgactcaaaa atggatacaa tcaggccata    720

ttgccacata ttacacaatc caggatgaag cctatgacac cactgatagt ctattagaag    780

aaaacaaaat atatgaaaga tcaaggtcat ctgatggcaa atcatcatct caagtgaaca    840

ggtcaagaca tgaaaataca agccaggtac cattgcagga gtccaggaca agaaagcgta    900

ggggatccag agttagccag gacagggaca gtgagggaca ctcagaagac tctgagaggc    960

actctgggtc ggcttccaga aaccatcatg gatctgcgtg ggagcagtca agagatggct   1020

ccagacaccc caggtcccat gatgaagaca gagccagtca tgggcactct gcagacagct   1080

ccagacaatc aggcactcgt cacgcagaga cttcctctcg tggacagact gcatcatccc   1140

atgaacaggc aagatcaagt ccaggagaaa gacatggatc cggccaccag cagtcagcag   1200

acagctccag acactcagcc actgggcgcg ggcaagcttc atctgcagtc agcgatcgtg   1260

gacaccgggg gtctagcggt agtcaggcca gtgacagtga gggacattca gaaaactcag   1320

acacacaatc agtgtcaggc cacggaaagg ctgggctgag acagcagagc caccaagagt   1380

ccacacgtgg ccggtcaggg gaacggtctg gacgttcagg gtcttccctc taccaggtga   1440

gcactcatga acagcctgac tctgcccatg gacggaccgg gaccagcact ggaggaagac   1500

aaggatcgca ccacgagcag gcacgagaca gctccaggca ttcagcgtcc caagagggtc   1560

aggacaccat tcgtggacac ccgggggaag gtctgatgcc tcccatgggc agtcaggatc   1620

cagaagtgca agcagacaaa cacgaaatga ggaacaatca ggagacggca ccaggcactc   1680

agggtcacgt catcatgaag cttcctctca ggctgacagc tctagacact cacaggtggg   1740

ccagggacaa tcatcggggc ccaggacaag taggaaccag ggatccagtg ttagccagga   1800

cagtgacagt cagggacact cagaagactc tgagaggtgg tctgggtctg cttccagaaa   1860

ccatcatgga tctgctcagg agcagtcaag agatggctcc agacacccca ggtcccatca   1920

cgaagacaga gctggtcatg ggcactctgc agacagctcc agaaaatcag gcactcgtca   1980

cacacagaat tcctctagtg gacaggctgc gtcatcccat gaacaggcaa gatcaagtgc   2040

aggagaaaga catggatccc gccaccagct ccagtcagca gacagctcca gacactcagg   2100

cactgggcac ggacaagctt catctgcagt cagagacagt ggacaccgag ggtccagtgg   2160

tagtcaggcc actgacagtg agggacattc agaagactca gacacacagt cagtgtcagg   2220

ccatggacag gctggtcacc atcagcagag ccaccaagag tccgcacgtg accggtcagg   2280

ggaaaggtct cgacgttcag ggtctttcct ctaccaggca ggccagggac aatcagaggg   2340

gtccaggaca agcaggcgcc agggatccag tgttagccag gacagtgaca gtgagggaca   2400

ttcagaagac tctgagaggt ggtctgggtc tgcttccaga aaccatcgtg gatctgctca   2460

ggagcagtca agacatggct ccagacaccc caggtcccat cacgaagaca gagccggtca   2520

cgggcactct gcagacagct ccagacaatc aggaactcct cacgcagaga cttcctctgg   2580

tggacaggct gcgtcatccc atgaacaggc aagatcaagt ccaggagaaa gacacggatc   2640

ccgccaccag cagtcagcag acagctccag acactcaggc attccgcgca gacaagcttc   2700

atctgcagtc agagacagtg gacactgggg gtccagtggt agtcaggcca gtgatagtga   2760

gcactcatga acagtctgag tctgcccatg ggcggaccag gaccagcact ggacgaagac   2820

aaggatccca ccacgagcag gcacgagaca gctccaggca ctcagcgtcc caagagggtc   2880

aggacaccat tcgtgcacac ccggggtcaa ggagaggagg aaggcaggga tcccaccatg   2940

agcaatcggt agatagatct ggacactcag ggtcccatca cagccacacc acatcccagg   3000

gaaggtctga tgcctcccat gggcagtcag gatccagaag tgcaagcaga caaactcgta   3060

aggacaaaca atcaggagac ggctccaggc actcagggtc acgtcaccat gaagctgcct   3120

cttgggctga cagctctaga cactcacagg tgggacagga acaatcatcg gggtccagga   3180

caagcaggca ccagggatcc agtgttagcc aggacagtga cagtgagaga cactcagacg   3240

actccgagag gttgtctggg tctgcttcca gaaaccatca tggatcttct cgggagcagt   3300

caagagatgg ctccagacac cctgggttcc atcaagaaga cagagccagt cacgggcact   3360

ctgcagacag ctccagacaa tcaggcactc atcacacaga gtcttcctct catggacagg   3420

ctgtgtcatc ccatgaacag gcaagatcaa gtccaggaga aagacatgga tcccgccacc   3480

agcagtcagc agacagctcc agacactcag gcattgggca cagacaagct tcatctgcag   3540

tcagagacag tggacaccga gggtccagtg gtagtcaggt cactaacagt gagggacatt   3600

cagaagactc agacacacag tcagtgtcag cccacggaca agctgggccc catcagcaga   3660

gccacaaaga gtccgcacgt ggccagtcag gggaaagctc tggacgttca aggtctttcc   3720

tctaccaggt gagctctcat gaacagtctg agtccacaca cggacagact gcacccagca   3780

ctggaggaag acaaggatcc cgccatgagc aggcacgaaa cagctctagg cactcagcat   3840

cccaagacgg tcaggacacc attcgtggac acccggggtc aagcagagga ggaaggcagg   3900

gatcctacca cgagcaatca gtagataggt ctggacactc agggtaccat cacagccaca   3960

ccacacccca gggaaggtct gatgcctccc atgggcagtc aggacccaga agtgcaagca   4020

ggcaaacaag aaatgaggaa caatcaggag acggctccag gcactcaggg tcacgtcacc   4080

atgaaccttc cactcgggcc ggcagctcta gacactcaca ggtgggccag ggagaatcag   4140

cggggtccaa gacaagcagg cgccagggat ccagtgttag tcaggacagg gacagtgagg   4200

gacactcaga agactctgag aggcggtctg agtcggcttc cagaaaccat tatggatctg   4260

ctcgggagca gtcaagacat ggctccagga accccaggtc ccatcaagaa gatagagcca   4320

gtcatgggca ctctgcagag agctccagac aatcaggcac tcgtcatgca gagacttcct   4380

ctggtggaca ggctgcatca tcccaggaac aggcaaggtc aagtccagga gaaagacatg   4440

gatcccgcca ccagcagtca gcagacagct ccacagactc aggcactggg cgcagacaag   4500

attcatctgt agtcggagac agtggaaacc gagggtccag tggtagccag gccagtgaca   4560

gcgagggaca ctcagaagag tcagacacac agtcagtgtc agcccacgga caggctgggc   4620

cccatcagca gagccaccaa gagtccacac gtggccagtc aggggaaagg tctggacgtt   4680

cagggtcttt cctctaccag gtgagcactc atgaacagtc tgagtccgcc catggacgca   4740

cagggcccag cactggagga agacaaagat cccgccacga gcaggcacga gacagctcca   4800

ggcactcagc gtcccaagag ggtcaggaca ccattcgtgg acacccaggg tcaagcagag   4860

gaggaaggca gggatcccac tatgagcaat cggtagatag ttctggacac tcagggtctc   4920

atcacagcca caccacgtcc caggaaaggt ctgatgtctc ccgtgggcag tcaggatcca   4980

gaagtgtcag cagacaaaca cgtgggccag ggacaatcat cagggcccag gacaagcagg   5040

aaccagggat ccagtgttag                                               5060


<210>  6610
<211>  1678
<212>  PRT
<213>  Homosapiens

<400>  6610

Met Ser Thr Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys 
1               5                   10                  15      


Gln Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp 
    50                  55                  60                  


His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile 
                85                  90                  95      


Ser Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp 
            100                 105                 110         


Asn Lys Gln Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu 
        115                 120                 125             


Glu Arg Arg Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro 
    130                 135                 140                 


Arg Glu Thr Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu 
145                 150                 155                 160 


Arg Lys Gly Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn 
                165                 170                 175     


His His Asn Ser Ser Lys Lys Glu Lys Asn Lys Thr Glu Asn Thr Arg 
            180                 185                 190         


Leu Gly Asp Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu 
        195                 200                 205             


Asp Asn Glu Glu Gly Val Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr 
    210                 215                 220                 


Gln Lys Trp Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln 
225                 230                 235                 240 


Asp Glu Ala Tyr Asp Thr Thr Asp Ser Leu Leu Glu Glu Asn Lys Ile 
                245                 250                 255     


Tyr Glu Arg Ser Arg Ser Ser Asp Gly Lys Ser Ser Ser Gln Val Asn 
            260                 265                 270         


Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg 
        275                 280                 285             


Thr Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu 
    290                 295                 300                 


Gly His Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn 
305                 310                 315                 320 


His His Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro 
                325                 330                 335     


Arg Ser His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser 
            340                 345                 350         


Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln 
        355                 360                 365             


Thr Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His 
    370                 375                 380                 


Gly Ser Gly His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr 
385                 390                 395                 400 


Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg Gly His Arg Gly 
                405                 410                 415     


Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asn Ser 
            420                 425                 430         


Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly Leu Arg Gln Gln 
        435                 440                 445             


Ser His Gln Glu Ser Thr Arg Gly Arg Ser Gly Glu Arg Ser Gly Arg 
    450                 455                 460                 


Ser Gly Ser Ser Leu Tyr Gln Val Ser Thr His Glu Gln Pro Asp Ser 
465                 470                 475                 480 


Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His 
                485                 490                 495     


His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly 
            500                 505                 510         


Gln Asp Thr Ile Arg Gly His Pro Gly Glu Gly Leu Met Pro Pro Met 
        515                 520                 525             


Gly Ser Gln Asp Pro Glu Val Gln Ala Asp Lys His Glu Met Arg Asn 
    530                 535                 540                 


Asn Gln Glu Thr Ala Pro Gly Thr Gln Gly His Val Ile Met Lys Leu 
545                 550                 555                 560 


Pro Leu Arg Leu Thr Ala Leu Asp Thr His Arg Trp Ala Arg Asp Asn 
                565                 570                 575     


His Arg Gly Pro Gly Gln Val Gly Thr Arg Asp Pro Val Leu Ala Arg 
            580                 585                 590         


Thr Val Thr Val Arg Asp Thr Gln Lys Thr Leu Arg Gly Gly Leu Gly 
        595                 600                 605             


Leu Leu Pro Glu Thr Ile Met Asp Leu Leu Arg Ser Ser Gln Glu Met 
    610                 615                 620                 


Ala Pro Asp Thr Pro Gly Pro Ile Thr Lys Thr Glu Leu Val Met Gly 
625                 630                 635                 640 


Thr Leu Gln Thr Ala Pro Glu Asn Gln Ala Leu Val Thr His Arg Ile 
                645                 650                 655     


Pro Leu Val Asp Arg Leu Arg His Pro Met Asn Arg Gln Asp Gln Val 
            660                 665                 670         


Gln Glu Lys Asp Met Asp Pro Ala Thr Ser Ser Ser Gln Gln Thr Ala 
        675                 680                 685             


Pro Asp Thr Gln Ala Leu Gly Thr Asp Lys Leu His Leu Gln Ser Glu 
    690                 695                 700                 


Thr Val Asp Thr Glu Gly Pro Val Val Val Arg Pro Leu Thr Val Arg 
705                 710                 715                 720 


Asp Ile Gln Lys Thr Gln Thr His Ser Gln Cys Gln Ala Met Asp Arg 
                725                 730                 735     


Leu Val Thr Ile Ser Arg Ala Thr Lys Ser Pro His Val Thr Gly Gln 
            740                 745                 750         


Gly Lys Gly Leu Asp Val Gln Gly Leu Ser Ser Thr Arg Gln Ala Arg 
        755                 760                 765             


Asp Asn Gln Arg Gly Pro Gly Gln Ala Gly Ala Arg Asp Pro Val Leu 
    770                 775                 780                 


Ala Arg Thr Val Thr Val Arg Asp Ile Gln Lys Thr Leu Arg Gly Gly 
785                 790                 795                 800 


Leu Gly Leu Leu Pro Glu Thr Ile Val Asp Leu Leu Arg Ser Ser Gln 
                805                 810                 815     


Asp Met Ala Pro Asp Thr Pro Gly Pro Ile Thr Lys Thr Glu Pro Val 
            820                 825                 830         


Thr Gly Thr Leu Gln Thr Ala Pro Asp Asn Gln Glu Leu Leu Thr Gln 
        835                 840                 845             


Arg Leu Pro Leu Val Asp Arg Leu Arg His Pro Met Asn Arg Gln Asp 
    850                 855                 860                 


Gln Val Gln Glu Lys Asp Thr Asp Pro Ala Thr Ser Ser Gln Gln Thr 
865                 870                 875                 880 


Ala Pro Asp Thr Gln Ala Phe Arg Ala Asp Lys Leu His Leu Gln Ser 
                885                 890                 895     


Glu Thr Val Asp Thr Gly Gly Pro Val Val Val Arg Pro Val Ile Val 
            900                 905                 910         


Ser Thr His Glu Gln Ser Glu Ser Ala His Gly Arg Thr Arg Thr Ser 
        915                 920                 925             


Thr Gly Arg Arg Gln Gly Ser His His Glu Gln Ala Arg Asp Ser Ser 
    930                 935                 940                 


Arg His Ser Ala Ser Gln Glu Gly Gln Asp Thr Ile Arg Ala His Pro 
945                 950                 955                 960 


Gly Ser Arg Arg Gly Gly Arg Gln Gly Ser His His Glu Gln Ser Val 
                965                 970                 975     


Asp Arg Ser Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln 
            980                 985                 990         


Gly Arg Ser Asp Ala Ser His Gly  Gln Ser Gly Ser Arg  Ser Ala Ser 
        995                 1000                 1005             


Arg Gln  Thr Arg Lys Asp Lys  Gln Ser Gly Asp Gly  Ser Arg His 
    1010                 1015                 1020             


Ser Gly  Ser Arg His His Glu  Ala Ala Ser Trp Ala  Asp Ser Ser 
    1025                 1030                 1035             


Arg His  Ser Gln Val Gly Gln  Glu Gln Ser Ser Gly  Ser Arg Thr 
    1040                 1045                 1050             


Ser Arg  His Gln Gly Ser Ser  Val Ser Gln Asp Ser  Asp Ser Glu 
    1055                 1060                 1065             


Arg His  Ser Asp Asp Ser Glu  Arg Leu Ser Gly Ser  Ala Ser Arg 
    1070                 1075                 1080             


Asn His  His Gly Ser Ser Arg  Glu Gln Ser Arg Asp  Gly Ser Arg 
    1085                 1090                 1095             


His Pro  Gly Phe His Gln Glu  Asp Arg Ala Ser His  Gly His Ser 
    1100                 1105                 1110             


Ala Asp  Ser Ser Arg Gln Ser  Gly Thr His His Thr  Glu Ser Ser 
    1115                 1120                 1125             


Ser His  Gly Gln Ala Val Ser  Ser His Glu Gln Ala  Arg Ser Ser 
    1130                 1135                 1140             


Pro Gly  Glu Arg His Gly Ser  Arg His Gln Gln Ser  Ala Asp Ser 
    1145                 1150                 1155             


Ser Arg  His Ser Gly Ile Gly  His Arg Gln Ala Ser  Ser Ala Val 
    1160                 1165                 1170             


Arg Asp  Ser Gly His Arg Gly  Ser Ser Gly Ser Gln  Val Thr Asn 
    1175                 1180                 1185             


Ser Glu  Gly His Ser Glu Asp  Ser Asp Thr Gln Ser  Val Ser Ala 
    1190                 1195                 1200             


His Gly  Gln Ala Gly Pro His  Gln Gln Ser His Lys  Glu Ser Ala 
    1205                 1210                 1215             


Arg Gly  Gln Ser Gly Glu Ser  Ser Gly Arg Ser Arg  Ser Phe Leu 
    1220                 1225                 1230             


Tyr Gln  Val Ser Ser His Glu  Gln Ser Glu Ser Thr  His Gly Gln 
    1235                 1240                 1245             


Thr Ala  Pro Ser Thr Gly Gly  Arg Gln Gly Ser Arg  His Glu Gln 
    1250                 1255                 1260             


Ala Arg  Asn Ser Ser Arg His  Ser Ala Ser Gln Asp  Gly Gln Asp 
    1265                 1270                 1275             


Thr Ile  Arg Gly His Pro Gly  Ser Ser Arg Gly Gly  Arg Gln Gly 
    1280                 1285                 1290             


Ser Tyr  His Glu Gln Ser Val  Asp Arg Ser Gly His  Ser Gly Tyr 
    1295                 1300                 1305             


His His  Ser His Thr Thr Pro  Gln Gly Arg Ser Asp  Ala Ser His 
    1310                 1315                 1320             


Gly Gln  Ser Gly Pro Arg Ser  Ala Ser Arg Gln Thr  Arg Asn Glu 
    1325                 1330                 1335             


Glu Gln  Ser Gly Asp Gly Ser  Arg His Ser Gly Ser  Arg His His 
    1340                 1345                 1350             


Glu Pro  Ser Thr Arg Ala Gly  Ser Ser Arg His Ser  Gln Val Gly 
    1355                 1360                 1365             


Gln Gly  Glu Ser Ala Gly Ser  Lys Thr Ser Arg Arg  Gln Gly Ser 
    1370                 1375                 1380             


Ser Val  Ser Gln Asp Arg Asp  Ser Glu Gly His Ser  Glu Asp Ser 
    1385                 1390                 1395             


Glu Arg  Arg Ser Glu Ser Ala  Ser Arg Asn His Tyr  Gly Ser Ala 
    1400                 1405                 1410             


Arg Glu  Gln Ser Arg His Gly  Ser Arg Asn Pro Arg  Ser His Gln 
    1415                 1420                 1425             


Glu Asp  Arg Ala Ser His Gly  His Ser Ala Glu Ser  Ser Arg Gln 
    1430                 1435                 1440             


Ser Gly  Thr Arg His Ala Glu  Thr Ser Ser Gly Gly  Gln Ala Ala 
    1445                 1450                 1455             


Ser Ser  Gln Glu Gln Ala Arg  Ser Ser Pro Gly Glu  Arg His Gly 
    1460                 1465                 1470             


Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser Thr Asp  Ser Gly Thr 
    1475                 1480                 1485             


Gly Arg  Arg Gln Asp Ser Ser  Val Val Gly Asp Ser  Gly Asn Arg 
    1490                 1495                 1500             


Gly Ser  Ser Gly Ser Gln Ala  Ser Asp Ser Glu Gly  His Ser Glu 
    1505                 1510                 1515             


Glu Ser  Asp Thr Gln Ser Val  Ser Ala His Gly Gln  Ala Gly Pro 
    1520                 1525                 1530             


His Gln  Gln Ser His Gln Glu  Ser Thr Arg Gly Gln  Ser Gly Glu 
    1535                 1540                 1545             


Arg Ser  Gly Arg Ser Gly Ser  Phe Leu Tyr Gln Val  Ser Thr His 
    1550                 1555                 1560             


Glu Gln  Ser Glu Ser Ala His  Gly Arg Thr Gly Pro  Ser Thr Gly 
    1565                 1570                 1575             


Gly Arg  Gln Arg Ser Arg His  Glu Gln Ala Arg Asp  Ser Ser Arg 
    1580                 1585                 1590             


His Ser  Ala Ser Gln Glu Gly  Gln Asp Thr Ile Arg  Gly His Pro 
    1595                 1600                 1605             


Gly Ser  Ser Arg Gly Gly Arg  Gln Gly Ser His Tyr  Glu Gln Ser 
    1610                 1615                 1620             


Val Asp  Ser Ser Gly His Ser  Gly Ser His His Ser  His Thr Thr 
    1625                 1630                 1635             


Ser Gln  Glu Arg Ser Asp Val  Ser Arg Gly Gln Ser  Gly Ser Arg 
    1640                 1645                 1650             


Ser Val  Ser Arg Gln Thr Arg  Gly Pro Gly Thr Ile  Ile Arg Ala 
    1655                 1660                 1665             


Gln Asp  Lys Gln Glu Pro Gly  Ile Gln Cys 
    1670                 1675             


<210>  6611
<211>  4178
<212>  DNA
<213>  Homosapiens

<400>  6611
gctcgtggtg cgatccttgt cttcctccag tgctggtccc ggtccgtcca tgggcagagt     60

caggctgttc atgagtgctc acctggtaga gggaagaccc tgaacgtcca gaccgttccc    120

ctgaccggcc acgtgtggac tcttggtggc tctgctgtct cagcccagcc tttccgtggc    180

ctgacactga ttgtgtgtct gagttttctg aatgtccctc actgtcactg gcctgactac    240

cgctagaccc ccggtgtcca cgatcgctga ctgcagatga agcttgcccg cgcccagtgg    300

ctgagtgtct ggagctgtct gctgactgct ggtggccgga tccatgtctt tctcctggac    360

ttgatcttgc ctgttcatgg gatgatgcag tctgtccacg agaggaagtc tctgcgtgac    420

gagtgcctga ttgtctggag ctgtctgcag agtgcccatg actggctctg tcttcatcat    480

gggacctggg gtgtctggag ccatctcttg actgctccca cgcagatcca tgatggtttc    540

tggaagccga cccagagtgc ctctcagagt cttctgagtg tccctcactg tccctgtcct    600

ggctaactct ggatccccta cgctttcttg tcctggactc ctgcaatgac tcataatatg    660

cttgagccaa cttgaatacc atcagaagaa actcagtgaa gtcaattttc ttgttgtggt    720

ctatatccaa gtgatccatg aagacatcaa ccatatctgg gtcatctgga ttctgtacag    780

agggaagtca cagagggaga ctgcatcaga cagaatcaca ttatcagcca attaattcaa    840

agttaattta aggaacctga tctttgagta ttaaaaagtg ggacaaaatc tttttttttt    900

ttaagacttt tttgtctcat cctcattcag gtgttatatg tgaacaaaga tgtagactag    960

taaggtatca agatttgatg gggatatcca gacaacttgg agccaagtcc ccacagctgg   1020

atcagacaac ttttggtgac atctcacagt gtggattatc aagccagtgt atcagtctgg   1080

agcctaggtt ttttgccttt agctttgctc aggatgactt ctgctcttct atggcaatac   1140

ttgagaagct acagctttga ttagacgaga ggctatttca ataactttct cctgataaga   1200

agaccaccga ccgtggacgg attctggcca gtttacaaag gctgcatacc atagggcagg   1260

gcaccccact atggcaaaca ctaataatga tattgctcct gattttgttt ctgaagggaa   1320

tgcctctaag atttcttcat taattataag agactgggtc tcactctgtt gcccaagctg   1380

gagaacagtg gcaccatcat agctcactgc agccttcaac ttctgggctc aagtgcttct   1440

cccacctcag cctcccaagt agctgggaca acaggtgaaa ttgaaggcca gcttttggaa   1500

ctcaaccttc aaaggaactt aaaatttcca ttatgtagag tccctgagga aactggatcc   1560

actagctaca ctggctgaga atgctctcac cccaggattt catttttatt ttaccacatc   1620

attgttggta tcttaagatc aatgtactgg agcagcgggg tctcacaaag aggatacctg   1680

gtgacacgcc caggctttca gaatgcacta tagggcttta gtgacttgtc caggttcagc   1740

tgaaatgtgc catctgggac ctactaatgc ttgttgaact ttactggatc tcagaagctg   1800

ggtctcagaa gctcagatgt tcctcagagc tacgatatca acaacctgtg atgacagaga   1860

gaaggttgct ccatgatgga tttggaaact tactggctag ctaaacctga ctgaatggga   1920

aggaatgtgg atagctttgg aactctagtt tcactagatg agctggaatt tgtattttga   1980

caaattgcac gttatgatta ttaagtaatg caactgattt ttttttccct taaaacaaac   2040

aatctagaat ctgtgtaatc aaaataattt ctctaaaagg ctgcaagtat atgcttaaag   2100

tgttggggca ttcagagcat ttggaacatt acattctttt gaatgtcaat tggtagatga   2160

aaataccagc ttttaagtca tacatttgat tttttgaaac aatatgcatt tagagtttgt   2220

aagtcaagtg aataactgat aaggtaaaaa aaagggggag ttcattgttg agtatgaatt   2280

taaagtaacc agactgcctt ttgtccagtg gctgtcagta atttacttca gcaggcattt   2340

tttttttttt gaggctgttc tatgatatca tgacccttct tgtaggaatg tgcttccagt   2400

ggtgaggcag tctgagaatg tgtgaagcag tataatgaag ccagaccaag atggaagctt   2460

ggcctgggat ttgagcatca ggaaaactgt tgaagggtta tgtatacatc acacacacac   2520

acacacacac acacacacac acacacacac acacactctc ttccatactc ctataacaac   2580

gtatagtatt tactatacct ggtgacaggt atttactata cattgttgaa gatctataac   2640

atggaatgcc tagtgctaag tgcagtgtcc ttagtgaaat tgtattggtt tggaattatt   2700

tatgagtttg ggattatttg tcactaccct taaatgatct tgacactcac ctatttgaaa   2760

agatattgag gatttgccat ttgatattga ccagggtgta ttgtgcacaa atattgtgaa   2820

tatacatctg tctgtcctta aatcactgta agttttaact ggaatagatt tgctccacat   2880

tactcggtag ggctgatatt tcatgcctca tggatgagaa aagaataggc aaaaattata   2940

tctcgggctg cctcacacat cttttaacag gataagggaa aaataaatat aagacctatg   3000

agttatggca tcaggcttga actttaattt atgaattaaa ccaacaatat tattgattat   3060

tgcaattatc tatcttaatt tcatttgttc tccttttaaa aattaattat gtttatttta   3120

cctattgtga ataaagtcac tcctcccatg tgcttatttc ttgactctgg cactaattat   3180

tcttcagtgc ctagatttcc tgggactgct cagtttaagt aacttctgaa cattggtctc   3240

tgagagaaaa gacagtgaag tgggatctgt ggaaaaacac atctgcaaat gtctcatttt   3300

tttcttcagg ggtaagtttt cttccttgga gactcttgtc ttgaaaaagt gatactagat   3360

caccatttgg caagataatt acaaaaggca gatagagtaa ttattttaca tagctgttat   3420

agggtgacta agatctcagg gaatgactgt gttctgtaat ccacttgccc cactcaatac   3480

cccaagtttt atacaagcca aagatgcttg gagcagaatc tgctacctga ggctccaggg   3540

ccttggccta gggaaactaa tacttaactt tttaagtggt cattgatgac atcccactcc   3600

tttctgagat gggtatgatt tgaaaggcag gtgtattcat ggagagcagg gcttgggacc   3660

tttgctgcaa gaggaggaac tattagccta gacttttcta ataaggactt tctcatacct   3720

gtttcctaga tctggtccac atagaagaaa tcagggaaca cacagggtag gactcttaaa   3780

ggagtatgtt tcttggcttt ttcctaaaaa ctaaaacaaa aacattcata gcaaagcagt   3840

ttagcccagt gactaagagt atagacattg gaatctgaaa gatctgggtt ggaattctgc   3900

ttcagccatt tactaattat gtaacttcac atctctgaga atgggggaaa ttttctttgc   3960

agggttgtta caaagcttaa aagagttaag tcaagtgcct ggaacagaac agccattcaa   4020

taaatcatag aaatttttgt ttttacacaa atttttaaaa agtaatattt tttgcatttg   4080

ttagaaagac tatattttct gtttagtgga tgacatcatc atcataaaaa tcactgttac   4140

aagttttgtt ttgagaatta aaatcatata ttaatccc                           4178


<210>  6612
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  6612

Met Gly Ile Ser Arg Gln Leu Gly Ala Lys Ser Pro Gln Leu Asp Gln 
1               5                   10                  15      


Thr Thr Phe Gly Asp Ile Ser Gln Cys Gly Leu Ser Ser Gln Cys Ile 
            20                  25                  30          


Ser Leu Glu Pro Arg Phe Phe Ala Phe Ser Phe Ala Gln Asp Asp Phe 
        35                  40                  45              


Cys Ser Ser Met Ala Ile Leu Glu Lys Leu Gln Leu 
    50                  55                  60  


<210>  6613
<211>  1136
<212>  DNA
<213>  Homosapiens

<400>  6613
ccaggttcac ttaaacttgc aaaaagatga ccgacctctt gagaagtgtt gtcaccgtaa     60

ttgatgtttt ctacaaatac accaagcaag atggggagtg tggcacactg agcaagggtg    120

aactaaagga acttctggag aaagagcttc atccagttct gaagaaccca gatgatccag    180

acacagtgga tgtcatcatg catatgctgg atcgagatca tgacagaaga ttggacttta    240

ctgagtttct tttgatgata ttcaagctga ctatggcctg caacaaggtc ctcagcaaag    300

aatactgcaa agcttcaggg tcaaagaagc ataggcgtgg tcaccgacac caagaagaag    360

aaagtgaaac agaagaggat gaagaggata caccaggaca taaatcaggt tacagacatt    420

caagttggag tgagggagag gagcatggat atagttctgg gcactcaagg ggaactgtga    480

aatgtagaca tgggtccaac tccaggaggc taggaagaca aggtaattta tccagctctg    540

ggaaccaaga gggatctcag aaaagatacc acaggtccag ctgtggtcat tcatggagtg    600

gtggcaaaga cagacatggt tccagctctg tagaactgag agaaagaata aacaagtcac    660

acattagccc ttctagggaa tctggggagg agtatgaatc tggatctgga tcaaacagtt    720

gggaaaggaa agatttggag ggcaaggaaa tcaatttagc tatattcagt caggctgtca    780

gtcaggaatt aagggaggac aaggccatgg ctgtgtctca ggaggtcagc cctctggatg    840

tggtcaacct gagtctaacc cctgtagtca gtcctatagt cagagaggat atggagctag    900

agaaaatggt caaccacaga actgtggagg acaatggaga acaggctcaa gtcagtcctc    960

ttgctgtgga caatatgggt ctggaggtag ccagtcttgt agtaatggtc aacatgaata   1020

tggttcctgt ggccgctttt caaactcttc tagttcaaat gaattttcca aatgtgatca   1080

atatgggtct ggttcaagtc agtctactag ctttgaacaa catggaacag gcttga       1136


<210>  6614
<211>  369
<212>  PRT
<213>  Homosapiens

<400>  6614

Met Thr Asp Leu Leu Arg Ser Val Val Thr Val Ile Asp Val Phe Tyr 
1               5                   10                  15      


Lys Tyr Thr Lys Gln Asp Gly Glu Cys Gly Thr Leu Ser Lys Gly Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Leu His Pro Val Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Thr Val Asp Val Ile Met His Met Leu Asp Arg Asp 
    50                  55                  60                  


His Asp Arg Arg Leu Asp Phe Thr Glu Phe Leu Leu Met Ile Phe Lys 
65                  70                  75                  80  


Leu Thr Met Ala Cys Asn Lys Val Leu Ser Lys Glu Tyr Cys Lys Ala 
                85                  90                  95      


Ser Gly Ser Lys Lys His Arg Arg Gly His Arg His Gln Glu Glu Glu 
            100                 105                 110         


Ser Glu Thr Glu Glu Asp Glu Glu Asp Thr Pro Gly His Lys Ser Gly 
        115                 120                 125             


Tyr Arg His Ser Ser Trp Ser Glu Gly Glu Glu His Gly Tyr Ser Ser 
    130                 135                 140                 


Gly His Ser Arg Gly Thr Val Lys Cys Arg His Gly Ser Asn Ser Arg 
145                 150                 155                 160 


Arg Leu Gly Arg Gln Gly Asn Leu Ser Ser Ser Gly Asn Gln Glu Gly 
                165                 170                 175     


Ser Gln Lys Arg Tyr His Arg Ser Ser Cys Gly His Ser Trp Ser Gly 
            180                 185                 190         


Gly Lys Asp Arg His Gly Ser Ser Ser Val Glu Leu Arg Glu Arg Ile 
        195                 200                 205             


Asn Lys Ser His Ile Ser Pro Ser Arg Glu Ser Gly Glu Glu Tyr Glu 
    210                 215                 220                 


Ser Gly Ser Gly Ser Asn Ser Trp Glu Arg Lys Asp Leu Glu Gly Lys 
225                 230                 235                 240 


Glu Ile Asn Leu Ala Ile Phe Ser Gln Ala Val Ser Gln Glu Leu Arg 
                245                 250                 255     


Glu Asp Lys Ala Met Ala Val Ser Gln Glu Val Ser Pro Leu Asp Val 
            260                 265                 270         


Val Asn Leu Ser Leu Thr Pro Val Val Ser Pro Ile Val Arg Glu Asp 
        275                 280                 285             


Met Glu Leu Glu Lys Met Val Asn His Arg Thr Val Glu Asp Asn Gly 
    290                 295                 300                 


Glu Gln Ala Gln Val Ser Pro Leu Ala Val Asp Asn Met Gly Leu Glu 
305                 310                 315                 320 


Val Ala Ser Leu Val Val Met Val Asn Met Asn Met Val Pro Val Ala 
                325                 330                 335     


Ala Phe Gln Thr Leu Leu Val Gln Met Asn Phe Pro Asn Val Ile Asn 
            340                 345                 350         


Met Gly Leu Val Gln Val Ser Leu Leu Ala Leu Asn Asn Met Glu Gln 
        355                 360                 365             


Ala 
    


<210>  6615
<211>  711
<212>  DNA
<213>  Homosapiens

<400>  6615
agatcagtct acgcaaatgt gtttgggtgc aatgtacctg gcaatttcat ggggcagtcg     60

ggaggacagt gtggctgaag cacagtgagt gagaggaaaa cagcaatgaa gtgaatgcaa    120

ctgatgcctc ctcaaaagtt tgctacctgc caagactttc aagcatgaaa atatctttat    180

ttttcccttt taaaattgat gggtaggcca tatgggagag agggaaatac tgacaaagag    240

ggcacctcaa gaaaagcatg cctataaaaa taatgtgaca aacaatgaaa caacacacaa    300

acagtttgac agataagaga gcaaaggatc accacacgcc cgtgattcta gagcaagtgg    360

tgactttagt gtgtggctgt gctcatgcat atggacctta cacaactgca atcagcatct    420

gcatacctac acccagtaac ctgctttctc tacctaatat gatataatga gcatttttct    480

atattgctac atagtcttta taattacttt aaatgactgt ataatattcc attcattata    540

tcactgctga atatttaggt tgcttgtagt ttttcctttg ctcattttta tgaattaaca    600

aatgtaaagt atttcaccca ctaccttcaa attatatata cttggtcggc actttatttc    660

cttcccgttc tgccccttta tataaataaa gaaaagtatg aaagattcat a             711


<210>  6616
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  6616

Met Lys Gln His Thr Asn Ser Leu Thr Asp Lys Arg Ala Lys Asp His 
1               5                   10                  15      


His Thr Pro Val Ile Leu Glu Gln Val Val Thr Leu Val Cys Gly Cys 
            20                  25                  30          


Ala His Ala Tyr Gly Pro Tyr Thr Thr Ala Ile Ser Ile Cys Ile Pro 
        35                  40                  45              


Thr Pro Ser Asn Leu Leu Ser Leu Pro Asn Met Ile 
    50                  55                  60  


<210>  6617
<211>  1902
<212>  DNA
<213>  Homosapiens

<400>  6617
actcctcaca ccacttaaca gccacttgtt tcatcccacc tgggcattag gttgacttca     60

aagatgcctc agttactgca aaacattaat gggatcatcg aggccttcag gcgctatgca    120

aggacggagg gcaactgcac agcgctcacc cgaggggagc tgaaaagact cttggagcaa    180

gagtttgccg atgtgattgt gaaaccccac gatccagcaa ctgtggatga ggtcctgcgt    240

ctgctggatg aagaccacac agggactgtg gaattcaagg aattcctggt cttagtgttt    300

aaagttgccc aggcctgttt caagacactg agcgagagtg ctgagggagc ctgcggctct    360

caagagtctg gaagcctcca ctctggggcc tcgcaggagc tgggcgaagg acagagaagt    420

ggcactgaag tgggaagggc ggggaaaggg cagcattatg aggggagcag ccacagacag    480

agccagcagg gttccagagg gcagaacagg cctggggttc agacccaggg tcaggccact    540

ggctctgcgt gggtcagcag ctatgacagg caagctgagt cccagagcca ggaaagaata    600

agcccgcaga tacaactctc tgggcagaca gagcagaccc agaaagctgg agaaggcaag    660

aggaatcaga caacagagat gaggccagag agacagccac agaccaggga acaggacaga    720

gcccaccaga caggtgagac tgtgactgga tctggaactc agacccaggc aggtgccacc    780

cagactgtgg agcaggacag cagccaccag acaggaagaa ccagcaagca gacacaggag    840

gccaccaatg accagaacag agggactgag acccacggtc aaggcaggag ccagaccagc    900

caggctgtga caggaggaca tgctcagata caggcaggga cacacaccca gacacccacc    960

cagaccgtgg agcaggacag cagccaccag acaggaagca ccagcaccca gacacaggag   1020

tccaccaatg gccagaacag agggactgag atccacggtc aaggcaggag ccagaccagc   1080

caggctgtga caggaggaca cactcagata caggcagggt cacacaccga gactgtggag   1140

caggacagaa gccaaactgt aagccacgga ggggctagag aacagggaca gacccagacg   1200

cagccaggca gtggtcaaag atggatgcaa gtgagcaacc ctgaggcagg agagacagta   1260

ccgggaggac aggcccagac tggggcaagc actgagtcag gaaggcagga gtggagcagc   1320

actcacccaa ggcgctgtgt gacagaaggg cagggagaca gacagcccac agtggttggt   1380

gaggaatggg ttgatgacca ctcaagggag acagtgatcc tcaggctgga ccagggcaac   1440

ttgcatacca gtgtttcctc agcacagggc caggatgcag cccagtcaga agagaagcga   1500

ggcatcacag ctagagagct gtattcctac ttgagaagca ccaagccatg acttccccga   1560

ctccaatgtc cagtactgga agaagacagc tggagagagt ttggcttgtc ctgcatggcc   1620

aatccagtgg gtgcatccct ggacatcagc tcttcattat gcagcttccc ttttaggtct   1680

ttctcaatga gataatttct gcaaggagct ttctatcctg aactcttctt tcttacctgc   1740

tttgcggtgc agaccctctc aggagcagga agactcagag caagtcaccc ctttgtactg   1800

aattgtcctc atcttgtggg gggtttcagg actattttta tctctgacat ctctctattg   1860

ccccatctac cctaatgcat caataaaacc ttaagccact gg                      1902


<210>  6618
<211>  495
<212>  PRT
<213>  Homosapiens

<400>  6618

Met Pro Gln Leu Leu Gln Asn Ile Asn Gly Ile Ile Glu Ala Phe Arg 
1               5                   10                  15      


Arg Tyr Ala Arg Thr Glu Gly Asn Cys Thr Ala Leu Thr Arg Gly Glu 
            20                  25                  30          


Leu Lys Arg Leu Leu Glu Gln Glu Phe Ala Asp Val Ile Val Lys Pro 
        35                  40                  45              


His Asp Pro Ala Thr Val Asp Glu Val Leu Arg Leu Leu Asp Glu Asp 
    50                  55                  60                  


His Thr Gly Thr Val Glu Phe Lys Glu Phe Leu Val Leu Val Phe Lys 
65                  70                  75                  80  


Val Ala Gln Ala Cys Phe Lys Thr Leu Ser Glu Ser Ala Glu Gly Ala 
                85                  90                  95      


Cys Gly Ser Gln Glu Ser Gly Ser Leu His Ser Gly Ala Ser Gln Glu 
            100                 105                 110         


Leu Gly Glu Gly Gln Arg Ser Gly Thr Glu Val Gly Arg Ala Gly Lys 
        115                 120                 125             


Gly Gln His Tyr Glu Gly Ser Ser His Arg Gln Ser Gln Gln Gly Ser 
    130                 135                 140                 


Arg Gly Gln Asn Arg Pro Gly Val Gln Thr Gln Gly Gln Ala Thr Gly 
145                 150                 155                 160 


Ser Ala Trp Val Ser Ser Tyr Asp Arg Gln Ala Glu Ser Gln Ser Gln 
                165                 170                 175     


Glu Arg Ile Ser Pro Gln Ile Gln Leu Ser Gly Gln Thr Glu Gln Thr 
            180                 185                 190         


Gln Lys Ala Gly Glu Gly Lys Arg Asn Gln Thr Thr Glu Met Arg Pro 
        195                 200                 205             


Glu Arg Gln Pro Gln Thr Arg Glu Gln Asp Arg Ala His Gln Thr Gly 
    210                 215                 220                 


Glu Thr Val Thr Gly Ser Gly Thr Gln Thr Gln Ala Gly Ala Thr Gln 
225                 230                 235                 240 


Thr Val Glu Gln Asp Ser Ser His Gln Thr Gly Arg Thr Ser Lys Gln 
                245                 250                 255     


Thr Gln Glu Ala Thr Asn Asp Gln Asn Arg Gly Thr Glu Thr His Gly 
            260                 265                 270         


Gln Gly Arg Ser Gln Thr Ser Gln Ala Val Thr Gly Gly His Ala Gln 
        275                 280                 285             


Ile Gln Ala Gly Thr His Thr Gln Thr Pro Thr Gln Thr Val Glu Gln 
    290                 295                 300                 


Asp Ser Ser His Gln Thr Gly Ser Thr Ser Thr Gln Thr Gln Glu Ser 
305                 310                 315                 320 


Thr Asn Gly Gln Asn Arg Gly Thr Glu Ile His Gly Gln Gly Arg Ser 
                325                 330                 335     


Gln Thr Ser Gln Ala Val Thr Gly Gly His Thr Gln Ile Gln Ala Gly 
            340                 345                 350         


Ser His Thr Glu Thr Val Glu Gln Asp Arg Ser Gln Thr Val Ser His 
        355                 360                 365             


Gly Gly Ala Arg Glu Gln Gly Gln Thr Gln Thr Gln Pro Gly Ser Gly 
    370                 375                 380                 


Gln Arg Trp Met Gln Val Ser Asn Pro Glu Ala Gly Glu Thr Val Pro 
385                 390                 395                 400 


Gly Gly Gln Ala Gln Thr Gly Ala Ser Thr Glu Ser Gly Arg Gln Glu 
                405                 410                 415     


Trp Ser Ser Thr His Pro Arg Arg Cys Val Thr Glu Gly Gln Gly Asp 
            420                 425                 430         


Arg Gln Pro Thr Val Val Gly Glu Glu Trp Val Asp Asp His Ser Arg 
        435                 440                 445             


Glu Thr Val Ile Leu Arg Leu Asp Gln Gly Asn Leu His Thr Ser Val 
    450                 455                 460                 


Ser Ser Ala Gln Gly Gln Asp Ala Ala Gln Ser Glu Glu Lys Arg Gly 
465                 470                 475                 480 


Ile Thr Ala Arg Glu Leu Tyr Ser Tyr Leu Arg Ser Thr Lys Pro 
                485                 490                 495 


<210>  6619
<211>  818
<212>  DNA
<213>  Homosapiens

<400>  6619
caggtagagt gcttctcagg accaggatga actcttggtg ctggtgtttt gggcagaaag     60

agcccctggg tggaggttga ggccattctt gaagaaagac aaggataaag aaggattttg    120

gaggggaagg ttcttctgga aggggagggt ggaagcttta ttcagcttct acagagatgt    180

cctgccagca gagccagcag cagtgccagc ctcctcccaa atgtacccct aaatgccctc    240

ccaagtgtac tcctaagtgt cctcccaagt gtcccccaaa atgccctccc cagtgttcag    300

ccccatgccc acctccagtc tcttcctgct gtggttccag ctctgggggc tgctgcagct    360

ctgagggtgg tggctgctgc ctgagccacc acaggccccg ccagtccctc cgacgccgac    420

ctcagagttc cagctgctgt ggcagtggca gtggccagca gtctgggggc tccagctgct    480

gccacagctc tgggggctct ggctgctgcc acagctctgg aggctgctgc tgacctgggc    540

catgaggagc acggaggaga aggactggca gatcccaggt gctgaagatg tgtgtcagcc    600

tgaggcttct tttctctcat ttcccatgga aggacttcgg aaatgcctta agttcccctc    660

tttatcctgc ccatgttcac tccattgtag ggttgaagtc tagcttgtga tattttctgg    720

cctggctttc cctctcagac atagctcttt ggagaactag gtgttgtaat tcagttatga    780

agctattttc tctgtaacaa taaagctttt tattcctg                            818


<210>  6620
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  6620

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Pro Pro Lys Cys Thr Pro Lys Cys Pro Pro Lys Cys 
            20                  25                  30          


Pro Pro Lys Cys Pro Pro Gln Cys Ser Ala Pro Cys Pro Pro Pro Val 
        35                  40                  45              


Ser Ser Cys Cys Gly Ser Ser Ser Gly Gly Cys Cys Ser Ser Glu Gly 
    50                  55                  60                  


Gly Gly Cys Cys Leu Ser His His Arg Pro Arg Gln Ser Leu Arg Arg 
65                  70                  75                  80  


Arg Pro Gln Ser Ser Ser Cys Cys Gly Ser Gly Ser Gly Gln Gln Ser 
                85                  90                  95      


Gly Gly Ser Ser Cys Cys His Ser Ser Gly Gly Ser Gly Cys Cys His 
            100                 105                 110         


Ser Ser Gly Gly Cys Cys 
        115             


<210>  6621
<211>  357
<212>  DNA
<213>  Homosapiens

<400>  6621
atgtcctgcc agcagagcca gcagcagtgc cagcctcctc ccaaatgtac ccctaaatgc     60

cctcccaagt gtactcctaa gtgtcctccc aagtgtcccc caaaatgccc tccccagtgt    120

tcagccccat gcccacctcc agtctcttcc tgctgtggtt ccagctctgg gggctgctgc    180

agctctgagg gtggtggctg ctgcctgagc caccacaggc cccgccagtc cctccgacgc    240

cgacctcaga gttccagctg ctgtggcagt ggcagtggcc agcagtctgg gggctccagc    300

tgctgccaca gctctggggg ctctggctgc tgccacagct ctggaggctg ctgctga       357


<210>  6622
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  6622

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Pro Pro Lys Cys Thr Pro Lys Cys Pro Pro Lys Cys 
            20                  25                  30          


Pro Pro Lys Cys Pro Pro Gln Cys Ser Ala Pro Cys Pro Pro Pro Val 
        35                  40                  45              


Ser Ser Cys Cys Gly Ser Ser Ser Gly Gly Cys Cys Ser Ser Glu Gly 
    50                  55                  60                  


Gly Gly Cys Cys Leu Ser His His Arg Pro Arg Gln Ser Leu Arg Arg 
65                  70                  75                  80  


Arg Pro Gln Ser Ser Ser Cys Cys Gly Ser Gly Ser Gly Gln Gln Ser 
                85                  90                  95      


Gly Gly Ser Ser Cys Cys His Ser Ser Gly Gly Ser Gly Cys Cys His 
            100                 105                 110         


Ser Ser Gly Gly Cys Cys 
        115             


<210>  6623
<211>  699
<212>  DNA
<213>  Homosapiens

<400>  6623
gcccattcca gttggagaac gtagtgagtc tttcagtgga gccagggtct ggtttgtcgt     60

gaggagctcc gcgatgtcct ctcaacagag cgccgtttcc gccaaaggct tttccaaggg    120

gtcgtcccag ggccccgctc cgtgtcccgc cccggcgccc accccggcgc ccgcctcctc    180

ctcctcctgc tgcggctccg gcaggggctg ctgcggcgac tcaggctgct gcggctccag    240

ctccaccagt tgctgctgct tcccaaggag acgccgccga cagcggagta gtggttgctg    300

ctgctgcggg ggcggcagcc agaggtccca gcgctccaac aaccggagct caggatgctg    360

ctccggctgc tgagaggccc gcaaccccca gcgctgcgct agagaaaccc gcccagccca    420

gagcgggccc gccccgctgc ggctcccacg cggggctggg cctcggagtt tgccccgtaa    480

agcgaattgc actttgatgt tcagaaaccc actttgttct cagccacgca aaactccctg    540

accccgatgt gatttttctc cccggggatt cgagagccat gcgtgggaca ctggacccta    600

ctgtctacac gggcttgcac acagcaggtg ctcagcaaat gtctattgat ttgattgtct    660

tttgaagatg tcataataaa gcttctacct cctgagaac                           699


<210>  6624
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  6624

Met Ser Ser Gln Gln Ser Ala Val Ser Ala Lys Gly Phe Ser Lys Gly 
1               5                   10                  15      


Ser Ser Gln Gly Pro Ala Pro Cys Pro Ala Pro Ala Pro Thr Pro Ala 
            20                  25                  30          


Pro Ala Ser Ser Ser Ser Cys Cys Gly Ser Gly Arg Gly Cys Cys Gly 
        35                  40                  45              


Asp Ser Gly Cys Cys Gly Ser Ser Ser Thr Ser Cys Cys Cys Phe Pro 
    50                  55                  60                  


Arg Arg Arg Arg Arg Gln Arg Ser Ser Gly Cys Cys Cys Cys Gly Gly 
65                  70                  75                  80  


Gly Ser Gln Arg Ser Gln Arg Ser Asn Asn Arg Ser Ser Gly Cys Cys 
                85                  90                  95      


Ser Gly Cys 
            


<210>  6625
<211>  510
<212>  DNA
<213>  Homosapiens

<400>  6625
atgtcctgcc agcagaacca gaagcagtgc caacccccac ccaagtgccc ctcacccaag     60

tgtcccccaa agaacccagt acagtgtctg cctccagctt cctctggctg tgccccaagc    120

tctgggggct gtggccctag ctccgagggc ggctgcttcc tgaaccacca caggcgccac    180

caccgatgcc ggcgccagag gtccaactcc tgtgacaggg gcagtggtca gcaaggcggg    240

ggctctggct gctgccacgg ttctgggggc tgctgctgat ccagatcctg atgctgagac    300

aagcgatctt tggaggaaac aagaatccca agaggccaag aacagcccca tctgacgcat    360

gccttcccat ataccctctt ctgactttca caggctgagc tggaggtttt cctgtggggg    420

atctgagctc tccccagaag gcacttcttg ttttatgtac aggatgtcat atgtccccct    480

acccctgtac ctgccaagga ttggcagtgc                                     510


<210>  6626
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  6626

Met Ser Cys Gln Gln Asn Gln Lys Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Ser Pro Lys Cys Pro Pro Lys Asn Pro Val Gln Cys Leu Pro Pro 
            20                  25                  30          


Ala Ser Ser Gly Cys Ala Pro Ser Ser Gly Gly Cys Gly Pro Ser Ser 
        35                  40                  45              


Glu Gly Gly Cys Phe Leu Asn His His Arg Arg His His Arg Cys Arg 
    50                  55                  60                  


Arg Gln Arg Ser Asn Ser Cys Asp Arg Gly Ser Gly Gln Gln Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Cys Cys His Gly Ser Gly Gly Cys Cys 
                85                  90          


<210>  6627
<211>  612
<212>  DNA
<213>  Homosapiens

<400>  6627
ctcaggaaca gccttctcct gcctcctctg cacctggaca actcaactcc tgccaagatg     60

tcctgccagc agaaccagca gcagtgccaa cccccaccca agtgtccctc acccaagtgt    120

cccccaaaga gcccagtaca gtgtctgcct ccagcttcct ctggctgtgc cccaagctct    180

gggggctgtg gccctagctc cgagggcggc tgcttcctga accaccacag gcgccaccac    240

cgatgccggc gccagaggcc caactcctgt gacaggggca gtggtcagca aggcgggggc    300

tctggctgcg gccatggctc tggaggctgc tgctgacctg gatcctgatg ctgagacaag    360

cgattttgga ggaaacaaga atcccaaggg cccaggaaaa ccccatcttg atgcatgagt    420

tcccagatac cctcttctgg ctttcacagg ctgagctagg ggttttcctg tggaaggtct    480

gagctctccc cagaaggcac ttcctgtctg atgtccagga tgtcacatgt tcccttaccc    540

ctgtacctgt gaaggattgg cagtgcttgt gcctgacctc atcaaaaaat aaagctcctt    600

gtcctcatta cc                                                        612


<210>  6628
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  6628

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Ser Pro Lys Cys Pro Pro Lys Ser Pro Val Gln Cys Leu Pro Pro 
            20                  25                  30          


Ala Ser Ser Gly Cys Ala Pro Ser Ser Gly Gly Cys Gly Pro Ser Ser 
        35                  40                  45              


Glu Gly Gly Cys Phe Leu Asn His His Arg Arg His His Arg Cys Arg 
    50                  55                  60                  


Arg Gln Arg Pro Asn Ser Cys Asp Arg Gly Ser Gly Gln Gln Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Cys Gly His Gly Ser Gly Gly Cys Cys 
                85                  90          


<210>  6629
<211>  295
<212>  DNA
<213>  Homosapiens

<400>  6629
tcctgcaaag atgtcctgcc agcaaaacca gcagcagtgc cagccccctc ccagttgtcc     60

ctcacccaag tgtcccccaa agagcccagc acagtgtctg cctccaccct cttctgactg    120

tgctctaagc tccgggggct gtggccccag ttctgaaagt ggctgctgcc tgagccacca    180

caggcacttc aggtcccatc aatgccggcg ccagagatcc aactcctgtg acaggggcag    240

tggtcagcaa ggcgggggct cctgccgtgg ccatggctct gggggctgct gctga         295


<210>  6630
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  6630

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Ser Cys 
1               5                   10                  15      


Pro Ser Pro Lys Cys Pro Pro Lys Ser Pro Ala Gln Cys Leu Pro Pro 
            20                  25                  30          


Pro Ser Ser Asp Cys Ala Leu Ser Ser Gly Gly Cys Gly Pro Ser Ser 
        35                  40                  45              


Glu Ser Gly Cys Cys Leu Ser His His Arg His Phe Arg Ser His Gln 
    50                  55                  60                  


Cys Arg Arg Gln Arg Ser Asn Ser Cys Asp Arg Gly Ser Gly Gln Gln 
65                  70                  75                  80  


Gly Gly Gly Ser Cys Arg Gly His Gly Ser Gly Gly Cys Cys 
                85                  90                  


<210>  6631
<211>  288
<212>  DNA
<213>  Homosapiens

<400>  6631
atgtcctgcc agcagaacca gcagcagtgc cagcctctgc ccaagtgccc ctcacccaag     60

tgccccccaa agagctcagc acagtgtctg cctccagcct cctcctgctg tgctccaaga    120

cctgggtgct gtggtggccc cagctctgag ggcggctgct gcctgagcca ccacaggtgc    180

tgcaggtccc accgatgccg gcgccagagc tccaactcct gtgacagagg cagtggtcag    240

caagatggtg cctccgactg tggctatggc tctggaggct gctgctga                 288


<210>  6632
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  6632

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Leu Pro Lys Cys 
1               5                   10                  15      


Pro Ser Pro Lys Cys Pro Pro Lys Ser Ser Ala Gln Cys Leu Pro Pro 
            20                  25                  30          


Ala Ser Ser Cys Cys Ala Pro Arg Pro Gly Cys Cys Gly Gly Pro Ser 
        35                  40                  45              


Ser Glu Gly Gly Cys Cys Leu Ser His His Arg Cys Cys Arg Ser His 
    50                  55                  60                  


Arg Cys Arg Arg Gln Ser Ser Asn Ser Cys Asp Arg Gly Ser Gly Gln 
65                  70                  75                  80  


Gln Asp Gly Ala Ser Asp Cys Gly Tyr Gly Ser Gly Gly Cys Cys 
                85                  90                  95  


<210>  6633
<211>  270
<212>  DNA
<213>  Homosapiens

<400>  6633
atgtcctgcc agcagaacca gcagcagtgc cagcctccgc ccaagtgccc tgcaaagagc     60

ccagcacagt gtctgcctcc agcttcctcc agctgtgccc caagctctgg gggctgtggg    120

cccagctccg agcgcagctg ctgcctgagt caccacagat gccgcaggtc tcaccgttgc    180

cgttgccaga gctccaactc ctgtgacagg ggaagtggtc agcaaggcgg gagctccagc    240

tgtggccaca gttctgcggg ctgctgctga                                     270


<210>  6634
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  6634

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Ala Lys Ser Pro Ala Gln Cys Leu Pro Pro Ala Ser Ser Ser Cys 
            20                  25                  30          


Ala Pro Ser Ser Gly Gly Cys Gly Pro Ser Ser Glu Arg Ser Cys Cys 
        35                  40                  45              


Leu Ser His His Arg Cys Arg Arg Ser His Arg Cys Arg Cys Gln Ser 
    50                  55                  60                  


Ser Asn Ser Cys Asp Arg Gly Ser Gly Gln Gln Gly Gly Ser Ser Ser 
65                  70                  75                  80  


Cys Gly His Ser Ser Ala Gly Cys Cys 
                85                  


<210>  6635
<211>  470
<212>  DNA
<213>  Homosapiens

<400>  6635
atgggcaaag tggctccaga actcaagggc agcctagata ctgatgaaga gctgcaggta     60

ctggctgttg aaggtgagaa aacaacagaa ggcccagtca ggcgagtgcc tgcctataaa    120

atgtgtgtca ggaccccgct tctcatctgc cctgacaccc tggggactgc ctgctccaca    180

cctgggtctg accagggtga gtggatcttt tggaacctag acagagcaca actgaaaggg    240

ttgactgaac tcccacaaag atgtcctgca ccagtctcat gcatctcgtt catcagtgcc    300

tttcatacct tcaagagctc ttgcctcaga gcattgctat gcctgaggtg tgtctcagaa    360

gcagccattg gcacagtggc ttggggctgg gctcaaaaat ttgctctctt gaagtttgga    420

tgtgattgct ctgaacaagc tgctttgcca caataaatat tttcaagttt               470


<210>  6636
<211>  151
<212>  PRT
<213>  Homosapiens

<400>  6636

Met Gly Lys Val Ala Pro Glu Leu Lys Gly Ser Leu Asp Thr Asp Glu 
1               5                   10                  15      


Glu Leu Gln Val Leu Ala Val Glu Gly Glu Lys Thr Thr Glu Gly Pro 
            20                  25                  30          


Val Arg Arg Val Pro Ala Tyr Lys Met Cys Val Arg Thr Pro Leu Leu 
        35                  40                  45              


Ile Cys Pro Asp Thr Leu Gly Thr Ala Cys Ser Thr Pro Gly Ser Asp 
    50                  55                  60                  


Gln Gly Glu Trp Ile Phe Trp Asn Leu Asp Arg Ala Gln Leu Lys Gly 
65                  70                  75                  80  


Leu Thr Glu Leu Pro Gln Arg Cys Pro Ala Pro Val Ser Cys Ile Ser 
                85                  90                  95      


Phe Ile Ser Ala Phe His Thr Phe Lys Ser Ser Cys Leu Arg Ala Leu 
            100                 105                 110         


Leu Cys Leu Arg Cys Val Ser Glu Ala Ala Ile Gly Thr Val Ala Trp 
        115                 120                 125             


Gly Trp Ala Gln Lys Phe Ala Leu Leu Lys Phe Gly Cys Asp Cys Ser 
    130                 135                 140                 


Glu Gln Ala Ala Leu Pro Gln 
145                 150     


<210>  6637
<211>  554
<212>  DNA
<213>  Homosapiens

<400>  6637
atgtcttgcc agcaaaacca gcagcagtgc cagccccctc ccaaatgtcc tcccaagtgt     60

accccaaaat gtccacctaa gtgtcccccc aaatgcccac cacagtgccc agctccatgt    120

tcccctgcag tctcttcctg ctgtggtccc agctctggga gctgctgtgg tcccagctct    180

gggggctgct gcagctctgg gggtggtggc tgctgcctga gccaccacag gccccgtctc    240

ttccaccggc gccggcacca gagccccgat tgctgtgaga gtgaaccttc tggggcctct    300

ggctgctgcc acagctctgg gggctgctgc tgacctgggc tgcagaagag ctctggtact    360

gaatggtcaa aaacctgcta cagcctgatg cttaactatt tccccttcct ttcattccac    420

tcatgggtgg acagggacca caaagactca tggggcttcc ccagaacttt gtgcttgatg    480

gagcacccca gatggaagcc ttctttttct cctttacctc atattgtaat aaagctctga    540

tttctgactc ttta                                                      554


<210>  6638
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  6638

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Pro Lys Cys Thr Pro Lys Cys Pro Pro Lys Cys Pro Pro Lys Cys 
            20                  25                  30          


Pro Pro Gln Cys Pro Ala Pro Cys Ser Pro Ala Val Ser Ser Cys Cys 
        35                  40                  45              


Gly Pro Ser Ser Gly Ser Cys Cys Gly Pro Ser Ser Gly Gly Cys Cys 
    50                  55                  60                  


Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser His His Arg Pro Arg Leu 
65                  70                  75                  80  


Phe His Arg Arg Arg His Gln Ser Pro Asp Cys Cys Glu Ser Glu Pro 
                85                  90                  95      


Ser Gly Ala Ser Gly Cys Cys His Ser Ser Gly Gly Cys Cys 
            100                 105                 110 


<210>  6639
<211>  333
<212>  DNA
<213>  Homosapiens

<400>  6639
atgtcttgcc agcaaaacca gcagcagtgc cagccccctc ccaagtgtcc tcccaagtgt     60

accccaaaat gtccacctaa gtgtcccccc aaatgcccac cacagtgccc agctccatgt    120

ttccctgcag tctcttcttg ctgtggtccc agctctggga gctgctgtgg tcccagctct    180

gggggctgct gcagctctgg ggctggtggc tgctccctga gccaccacag gccccgtctc    240

ttccaccggc gccggcacca gagccccgac tgctgtgaga gtgaaccttc tgggggctct    300

ggctgctgcc acagctctgg gggctgctgc tga                                 333


<210>  6640
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  6640

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Pro Lys Cys Thr Pro Lys Cys Pro Pro Lys Cys Pro Pro Lys Cys 
            20                  25                  30          


Pro Pro Gln Cys Pro Ala Pro Cys Phe Pro Ala Val Ser Ser Cys Cys 
        35                  40                  45              


Gly Pro Ser Ser Gly Ser Cys Cys Gly Pro Ser Ser Gly Gly Cys Cys 
    50                  55                  60                  


Ser Ser Gly Ala Gly Gly Cys Ser Leu Ser His His Arg Pro Arg Leu 
65                  70                  75                  80  


Phe His Arg Arg Arg His Gln Ser Pro Asp Cys Cys Glu Ser Glu Pro 
                85                  90                  95      


Ser Gly Gly Ser Gly Cys Cys His Ser Ser Gly Gly Cys Cys 
            100                 105                 110 


<210>  6641
<211>  609
<212>  DNA
<213>  Homosapiens

<400>  6641
cagggacgtg tctgtgctcc tgcgtgtgac cagggttgac taaactctgc caggatgtct     60

tgccagcaaa accagcagca gtgccagccc cctcccaagt gtcctcccaa gtgtacccca    120

aaatgtccac ctaagtgtcc ccctaaatgc ctgccccagt gcccagctcc atgttcccct    180

gcagtctctt cttgctgtgg tcccatctct gggggctgct gtggtcccag ctctgggggc    240

tgctgcaact ctggggctgg tggctgctgc ctgagccacc acaggccccg tctcttccac    300

cggcgccggc accagagccc cgactgctgt gagagtgaac cttctggggg ctctggctgc    360

tgccacagct ctgggggctg ctgctgacct gggctaagaa gaactctttg gacagaatgt    420

ttaagaacct cctacagcct gatgcttaac cctttccatt tcctctcatt ccattcatgg    480

gtggacagcg accacaaaga ctcatggggc ttccctggga gaactttgca cttgatggag    540

cacctcaatt gcaggttttg ttttcctcct ttacctcatg ttataataaa gctctgattt    600

ctgactcac                                                            609


<210>  6642
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  6642

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Pro Lys Cys Thr Pro Lys Cys Pro Pro Lys Cys Pro Pro Lys Cys 
            20                  25                  30          


Leu Pro Gln Cys Pro Ala Pro Cys Ser Pro Ala Val Ser Ser Cys Cys 
        35                  40                  45              


Gly Pro Ile Ser Gly Gly Cys Cys Gly Pro Ser Ser Gly Gly Cys Cys 
    50                  55                  60                  


Asn Ser Gly Ala Gly Gly Cys Cys Leu Ser His His Arg Pro Arg Leu 
65                  70                  75                  80  


Phe His Arg Arg Arg His Gln Ser Pro Asp Cys Cys Glu Ser Glu Pro 
                85                  90                  95      


Ser Gly Gly Ser Gly Cys Cys His Ser Ser Gly Gly Cys Cys 
            100                 105                 110 


<210>  6643
<211>  561
<212>  DNA
<213>  Homosapiens

<400>  6643
aggttgaaaa agtcgcactg agatgtcctg ccagcaaaac cagcagcagt gccagccccc     60

tcccaagtgc cccccaaaat gcccacccaa gtgtcctcca aagtgccgac ctcagtgccc    120

agccccatgc ccacctccag tctcttcctg ctgtggtccc agctctgggg gctgctgcgg    180

ctccagctct gggggctgct gcagctctgg gggtggcggc tgctgcctga gccaccacag    240

gccccgtctc ttccaccggc accggcacca gagccccgat tgttgtgagt gtgaaccttc    300

tgggggctct ggctgctgcc acagctctgg ggactgctgc tgaccagacc tcgaacatca    360

cagagcaacc cttatggaga aacttgcaac caggacctgt cccagagtga tgcttctcct    420

gccccttttt ctcctttcct tgggctgaca caccttgtga ggtgttttgt ctgttgtcat    480

ggcccaagag cccatcctgg atcctgatct taccttccca ctttacctca tacaacaata    540

aagctctttt gcctcttcgt g                                              561


<210>  6644
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  6644

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Pro Lys Cys Pro Pro Lys Cys Pro Pro Lys Cys Arg Pro Gln Cys 
            20                  25                  30          


Pro Ala Pro Cys Pro Pro Pro Val Ser Ser Cys Cys Gly Pro Ser Ser 
        35                  40                  45              


Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Cys Cys Ser Ser Gly Gly 
    50                  55                  60                  


Gly Gly Cys Cys Leu Ser His His Arg Pro Arg Leu Phe His Arg His 
65                  70                  75                  80  


Arg His Gln Ser Pro Asp Cys Cys Glu Cys Glu Pro Ser Gly Gly Ser 
                85                  90                  95      


Gly Cys Cys His Ser Ser Gly Asp Cys Cys 
            100                 105     


<210>  6645
<211>  674
<212>  DNA
<213>  Homosapiens

<400>  6645
agtgccgaag aggctatctg ggaagctcat catccagctc aggaagagat gaaaccagga     60

ggcaggagaa tgtcaggcat gaccccacac ttgtgcaaca gccacgtcct gctcctgcca    120

ttagcatggc tcatccgagg cccagcccca ggatccatac aaagtgtgtt cctgctgctg    180

gcttctcatc tgctctgctt cctaagggac gtatctgttg ctgcgtctga acccacggtt    240

tatcgaaatt ccaccaagat gtcctgccag cagaaccaac agcagtgcca gccccctccc    300

aagtgtccta tccccaagta tcccccaaaa tgtccctcaa agtgtgcatc ctcatgccca    360

cctccaatct cttcctgctg tggctccagc tctgggggct gtggttgctg cagctctgag    420

ggaggtggct gctgcctgag ccaccacaga caccataggt cccactgcca cagacccaag    480

agctccaatt gctatggcag tggcagtggc cagcagtctg ggggttctgg ctgctgctct    540

ggagggggct gttgctgacc tggaccagga gcagcaccaa aggaattagt gggcgaagga    600

cccattgcag cctggtgttt tacctccttc actctcttgc ctttcctttc tgtagcccca    660

tcaattgaat aaac                                                      674


<210>  6646
<211>  169
<212>  PRT
<213>  Homosapiens

<400>  6646

Met Lys Pro Gly Gly Arg Arg Met Ser Gly Met Thr Pro His Leu Cys 
1               5                   10                  15      


Asn Ser His Val Leu Leu Leu Pro Leu Ala Trp Leu Ile Arg Gly Pro 
            20                  25                  30          


Ala Pro Gly Ser Ile Gln Ser Val Phe Leu Leu Leu Ala Ser His Leu 
        35                  40                  45              


Leu Cys Phe Leu Arg Asp Val Ser Val Ala Ala Ser Glu Pro Thr Val 
    50                  55                  60                  


Tyr Arg Asn Ser Thr Lys Met Ser Cys Gln Gln Asn Gln Gln Gln Cys 
65                  70                  75                  80  


Gln Pro Pro Pro Lys Cys Pro Ile Pro Lys Tyr Pro Pro Lys Cys Pro 
                85                  90                  95      


Ser Lys Cys Ala Ser Ser Cys Pro Pro Pro Ile Ser Ser Cys Cys Gly 
            100                 105                 110         


Ser Ser Ser Gly Gly Cys Gly Cys Cys Ser Ser Glu Gly Gly Gly Cys 
        115                 120                 125             


Cys Leu Ser His His Arg His His Arg Ser His Cys His Arg Pro Lys 
    130                 135                 140                 


Ser Ser Asn Cys Tyr Gly Ser Gly Ser Gly Gln Gln Ser Gly Gly Ser 
145                 150                 155                 160 


Gly Cys Cys Ser Gly Gly Gly Cys Cys 
                165                 


<210>  6647
<211>  300
<212>  DNA
<213>  Homosapiens

<400>  6647
atgtcctgcc agcagaacca acagcagtgc cagccccctc ccaagtgtcc tatccccaag     60

tatcccccaa aatgtccctc aaagtgtgca tcctcatgcc cacctccaat ctcttcctgc    120

tgtggctcca gctctggggg ctgtggttgc tgcagctctg agggaggtgg ctgctgcctg    180

agccaccaca gacaccatag gtcccactgc cacagaccca agagctccaa ttgctatggc    240

agtggcagtg gccagcagtc tgggggttct ggctgctgct ctggaggggg ctgttgctga    300


<210>  6648
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  6648

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Ile Pro Lys Tyr Pro Pro Lys Cys Pro Ser Lys Cys Ala Ser Ser 
            20                  25                  30          


Cys Pro Pro Pro Ile Ser Ser Cys Cys Gly Ser Ser Ser Gly Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Ser Glu Gly Gly Gly Cys Cys Leu Ser His His Arg 
    50                  55                  60                  


His His Arg Ser His Cys His Arg Pro Lys Ser Ser Asn Cys Tyr Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Gln Gln Ser Gly Gly Ser Gly Cys Cys Ser Gly Gly 
                85                  90                  95      


Gly Cys Cys 
            


<210>  6649
<211>  730
<212>  DNA
<213>  Homosapiens

<400>  6649
ccagagccac gtccatgcct gcagccctgt gagcacccag agccttgtcc acgaccagag     60

ccaattcccc tgccggcgcc ctgcccaagc ccggagccct gcagggagac ttggcgcagc    120

cccagcccat gctggggccc aaatccagtt ccatacccag gagacctagg ctgtcatgag    180

tctagtccac accgcctaga caccgaagct ccctactgtg gcccatccag ttacaaccag    240

gggcaagaga gtggtgctgg ctgtgggcct ggtgatgtgt ttccagagcg gaggggtcag    300

gatggccatg gagaccaagg caatgccttt gctggagtga aaggggaagc aaagagtgct    360

tatttttaaa ggaaaggtga ctgagataac cctctctcct gctctgaaaa tgttgttcct    420

cctattccac aatttccagt acgctcttgt ttgaatctct ccaaagatat tcagagactc    480

cctattacga aggtgatgtc caaactcctt tgcctatcat ccaaagatcc acacctgggt    540

ctcagatgcc tctccagcct cacgtgtcac tcctcgccca atctctaaat ctcagtgtct    600

atcctggggc tggctgttgc ttagcaaggc ttgtgggttg gcagcttgaa ccatgttctg    660

tcctgatgct caactgcagg aactgaggtg agaggaggcc atgtgacaat aaagatcatt    720

atgtactcac                                                           730


<210>  6650
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  6650

Met Pro Leu Gln Pro His Val Ser Leu Leu Ala Gln Ser Leu Asn Leu 
1               5                   10                  15      


Ser Val Tyr Pro Gly Ala Gly Cys Cys Leu Ala Arg Leu Val Gly Trp 
            20                  25                  30          


Gln Leu Glu Pro Cys Ser Val Leu Met Leu Asn Cys Arg Asn 
        35                  40                  45      


<210>  6651
<211>  357
<212>  DNA
<213>  Homosapiens

<400>  6651
atgtcttgcc agcagagcca gcagcagtgc cagccccctc ccaagtgcac tcccaagtgc     60

cctcccaagt gccccacacc gaagtgcccc ccaaagtgtc cccctaagtg ccctcctgtc    120

tcttcctgct gcagcgtcag ctccggaggc tgctgtggct ccagctctgg gggctgctgc    180

agctctgggg gtggtggctg ctgcagctct gggggaggcg gctgttgcct gagccaccac    240

agacggcgta ggtcccaccg ccacagaccc cagagctctg actgctgcag ccagccctca    300

gcgggctcca gctgctgcgg agggggcagt ggccagcact ctggaggctg ctgctga       357


<210>  6652
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  6652

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Pro Pro Lys Cys Pro Thr Pro Lys Cys Pro Pro Lys 
            20                  25                  30          


Cys Pro Pro Lys Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser 
        35                  40                  45              


Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Cys Cys Ser Ser Gly Gly 
    50                  55                  60                  


Gly Gly Cys Cys Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser His His 
65                  70                  75                  80  


Arg Arg Arg Arg Ser His Arg His Arg Pro Gln Ser Ser Asp Cys Cys 
                85                  90                  95      


Ser Gln Pro Ser Ala Gly Ser Ser Cys Cys Gly Gly Gly Ser Gly Gln 
            100                 105                 110         


His Ser Gly Gly Cys Cys 
        115             


<210>  6653
<211>  575
<212>  DNA
<213>  Homosapiens

<400>  6653
gaaacccagg ctgggataaa agggctcagg gccagagcac cccattcact cacttcctga     60

ggtgccgaag gaccctgtgc tgcctgtgac tttggtatgt gtcctctggg aacagaagca    120

ggggattcca cagagggatg ctcagatcag ctcctaagta cctactgccg agatgtcctg    180

ccagcagagc cagcagcagt gccagccccc tcccaagtgc actcccaagt gccctcccaa    240

gtgtcccacc cccaaatgcc ctccaaagtg tccccctaag tgccctccag tctcttcctg    300

ctgcagtgtc agctccggag gctgctgtgg ctccagctct gggggcagct gtggctccag    360

ctctgggggc tgctgcagct ctgggggagg tggctgctgc ctgagccacc acaggcacca    420

caggtcccac cgtcacagac cccagagctc tgactgctgc agccagccct cagggggctc    480

cagctgctgt ggagggggca gcggccagca ctctggaggc tgctgctgaa gtggaccttg    540

acttcctctt ccttctgatt ctgcctgaat agctg                               575


<210>  6654
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  6654

Met Leu Arg Ser Ala Pro Lys Tyr Leu Leu Pro Arg Cys Pro Ala Ser 
1               5                   10                  15      


Arg Ala Ser Ser Ser Ala Ser Pro Leu Pro Ser Ala Leu Pro Ser Ala 
            20                  25                  30          


Leu Pro Ser Val Pro Pro Pro Asn Ala Leu Gln Ser Val Pro Leu Ser 
        35                  40                  45              


Ala Leu Gln Ser Leu Pro Ala Ala Val Ser Ala Pro Glu Ala Ala Val 
    50                  55                  60                  


Ala Pro Ala Leu Gly Ala Ala Val Ala Pro Ala Leu Gly Ala Ala Ala 
65                  70                  75                  80  


Ala Leu Gly Glu Val Ala Ala Ala 
                85              


<210>  6655
<211>  1177
<212>  DNA
<213>  Homosapiens

<400>  6655
gccgaaggac cctgtgctgc ctgtgacttt gctcctaagt acctactgcc gagatgtcct     60

gccagcagag ccagcagcag tgccagcccc ctcccaagtg cactcccaag tgccctccca    120

agtgtcccac ccccaaatgc cctccaaagt gtccccctaa gtgccctcca gtctcttcct    180

gctgcagtgt cagctccgga ggctgctgtg gctccagctc tgggggcagc tgtggctcca    240

gctctggggg ctgctgcagc tctgggggag gtggctgctg cctgagccac cacaggcacc    300

acaggtccca ccgtcacaga ccccagagct ctgactgctg cagccagccc tcagggggct    360

ccagctgctg tggagggggc agcggccagc actctggagg ctgctgctga agtggacctt    420

gacttcctct tccttctgat tctgcctgaa tagctgagag gttccagcaa aagcttgaag    480

tcttgcctgg agaatccctc tgctctggtg tcaggaaacc caaaatcttt ctccttaatg    540

gcatttagag actttcttct gcagatccat ggctgccctg ggaactccaa agcacacacc    600

tacttcctcc ccagctcacg ctgctgtatt ctgtgctgcc tgaactgaag aaataaaatc    660

cagaatctgc cccccaactt gctaccagcc tgcttgattt tcctgtttgt gtcatccttg    720

ttctgctccc ctgtgtctgc tggtggctgc tgaggccttg gtggacagag gatggggaaa    780

ggggtcagga ggaaaaagct tgcatttctg tgtgttttgt gttttttctt ctttcggtgt    840

tttcctttta aaccaaggga ctgaaatagc attgagaaat atttttcttt caaattctgg    900

ttcctttcac ctatgtaacc gcatccctca ggcatggcca ggaggccgac ttcatcctcc    960

ttcccactat cacctcttca ttcttgtgtt cctcgttccc cactccttcc actaacaatc   1020

tccctggact cctcctccat actgtatgtg catgcattca cacacacata tgtacatgca   1080

catagatgag atgaatctgc attgtaaaaa aattaaatca catttagtgc tgtataattt   1140

gcatgcaata aaattcaata aaattaaatg taaaatt                            1177


<210>  6656
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  6656

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Pro Pro Lys Cys Pro Thr Pro Lys Cys Pro Pro Lys 
            20                  25                  30          


Cys Pro Pro Lys Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser 
        35                  40                  45              


Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Ser Cys Gly Ser Ser Ser 
    50                  55                  60                  


Gly Gly Cys Cys Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser His His 
65                  70                  75                  80  


Arg His His Arg Ser His Arg His Arg Pro Gln Ser Ser Asp Cys Cys 
                85                  90                  95      


Ser Gln Pro Ser Gly Gly Ser Ser Cys Cys Gly Gly Gly Ser Gly Gln 
            100                 105                 110         


His Ser Gly Gly Cys Cys 
        115             


<210>  6657
<211>  410
<212>  DNA
<213>  Homosapiens

<400>  6657
gctcctgaac acccaccacc gagatgtcct gccagcagag ccagcagcag tgccagcccc     60

ctcccaagtg cactcccaag tgcactccca agtgccccgc ccctaaatgt ccccctaagt    120

gccctccagt ctcttcctgc tgcagtgtca gctccggagg ctgctgtggc tccagctctg    180

ggggcggctg tggctccaac tctgggggct gctgcagctc tgggggtggt ggctgctgcc    240

tgagccacca caggcgccac aggtcccacc gtcgcagacc ccagagctct gactgctgca    300

gccagccctc ggggggctcc agctgctgcg gtgggggcag cagccagcac tctggaggct    360

gctgctgaag tggaccttga cttcctcttc cttctgattc tgcctgaata               410


<210>  6658
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  6658

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Thr Pro Lys Cys Pro Ala Pro Lys Cys Pro Pro Lys 
            20                  25                  30          


Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser Gly Gly Cys Cys 
        35                  40                  45              


Gly Ser Ser Ser Gly Gly Gly Cys Gly Ser Asn Ser Gly Gly Cys Cys 
    50                  55                  60                  


Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser His His Arg Arg His Arg 
65                  70                  75                  80  


Ser His Arg Arg Arg Pro Gln Ser Ser Asp Cys Cys Ser Gln Pro Ser 
                85                  90                  95      


Gly Gly Ser Ser Cys Cys Gly Gly Gly Ser Ser Gln His Ser Gly Gly 
            100                 105                 110         


Cys Cys 
        


<210>  6659
<211>  576
<212>  DNA
<213>  Homosapiens

<400>  6659
gctcctgaat ccgccaccaa gatgtcctgc cagcagagcc agcagcagtg ccagccccct     60

cccaatgtca gctccggagg ctgctgtggc tccagctctg ggggcagctg tggctccagc    120

tctgggggat gctgcagttc tgggggaggt ggctgctgcc tgagccacca caggcgccgt    180

aggtcccact gccacagacc ccagagctct ggctgctgca gccagccctc ggggggctcc    240

agctgctgtg gcggggggag tggccagcac tctggaggct gctgctgaag tggaccctga    300

gcctagaaga gcagaatcca ggaccgcaaa ctgccaagga catccccctt ctcctactag    360

gcctgcctga gaggctcaca ggtccaaggg aaagctctga acttgccaag agcatatctt    420

ttccctggag tccagaaact cagatcctct cctggatctc cattcactgg ccttggacct    480

cacctttgtg gctaccctcc cacgctctgt ctaagcccct agcttactca atgtcatttg    540

cagcgtgcat ctgctgatta aaggactaaa acaagg                              576


<210>  6660
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  6660

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Asn Val 
1               5                   10                  15      


Ser Ser Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Ser Cys Gly Ser 
            20                  25                  30          


Ser Ser Gly Gly Cys Cys Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser 
        35                  40                  45              


His His Arg Arg Arg Arg Ser His Cys His Arg Pro Gln Ser Ser Gly 
    50                  55                  60                  


Cys Cys Ser Gln Pro Ser Gly Gly Ser Ser Cys Cys Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gln His Ser Gly Gly Cys Cys 
                85              


<210>  6661
<211>  357
<212>  DNA
<213>  Homosapiens

<400>  6661
atgtcctgcc agcagagcca gcagcagtgc cagccccctc ccaagtgcac ccccaagtgc     60

cctcccaagt gccccacccc aaagtgtccc ccaaagtgtc cccctaagtg ccctcctgtc    120

tcttcctgct gcagtgtcag ctccggaggc tgctgtggct ccagctctgg gggcagctgt    180

ggctccagct ctgggggatg ctgcagttct gggggaggtg gctgctgcct gagccaccac    240

aggcgccgta ggtcccactg ccacagaccc cagagctctg gctgctgcag ccagccctcg    300

gggggctcca gctgctgtgg cggggggagt ggccagcact ctggaggctg ctgctga       357


<210>  6662
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  6662

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Pro Pro Lys Cys Pro Thr Pro Lys Cys Pro Pro Lys 
            20                  25                  30          


Cys Pro Pro Lys Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser 
        35                  40                  45              


Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Ser Cys Gly Ser Ser Ser 
    50                  55                  60                  


Gly Gly Cys Cys Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser His His 
65                  70                  75                  80  


Arg Arg Arg Arg Ser His Cys His Arg Pro Gln Ser Ser Gly Cys Cys 
                85                  90                  95      


Ser Gln Pro Ser Gly Gly Ser Ser Cys Cys Gly Gly Gly Ser Gly Gln 
            100                 105                 110         


His Ser Gly Gly Cys Cys 
        115             


<210>  6663
<211>  1139
<212>  DNA
<213>  Homosapiens

<400>  6663
gttctgaact tctatgtcct tacaacaagg taatctagaa aattcttcca agagagaatg     60

actgtttccc cttgagaaac aattttattt ccaaacccct ttctagattg ttttcatgat    120

tcaggtgtgt agttgaagca gaatgtctcc tctacatact acatgcttga ttttgagaat    180

actttcttaa tatcttttgg cttcggtttt ctaattataa aatagttgaa aatgctttat    240

gattttataa gtatataaaa agcattaggt tcaaaacaga ggctataagt gtgtttagcc    300

aactattaga cacaatgaaa cttcccgtga ttaattagct acaactacac taagcagttc    360

atcaaaatgt agggattaga aatgatgctg aaagggcaag aataggccgg ggtggcctct    420

acctgggtct aacttgctgt ctgactctct ctcagctcct gaacacccgc accaagatgt    480

cctgccagca gaaccagcag cagtgccagc cccctcccaa gtgcatcccc aagtgccctc    540

ccaagtgcct cacccctaga tgccccccaa agtgtccccc taagtgtcct ccagtctctt    600

cctgctgcag tgtcagctcc ggaggctgct gtggctccag ctctggggga agctgtggct    660

ccagctctgg gggttgctgc agttctgggg gaggtggctg ctgcctgagc caccacaggc    720

gccgtaggtc ccactgccac agaccccaga gctctggctg ctgcagccag ccctccgggg    780

gctccagctg ctgtggagga gggagtggcc agcactctgg aggctgctgc taaagtggat    840

cctgagccta gaagaacaca aatggccaaa tatttccctt ccgtcttcct tctccttctg    900

ggcctgccca tgttgttgag aggtcttggt gagggctcaa ctcaagcata gaggattctt    960

ctgtcttgga gttcagaggc ccaaaacttc tcccccaaag ccaagccatt taatgacctc   1020

agtttgcgta tgtgtggttg ctctgggaag cccaaagcac agacctatat ccctttgcag   1080

cttgtctttt tgcatagctc agcctgatgt gaaacaataa aaccagaaat atgcattcc    1139


<210>  6664
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  6664

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Ile Pro Lys Cys Pro Pro Lys Cys Leu Thr Pro Arg Cys Pro Pro Lys 
            20                  25                  30          


Cys Pro Pro Lys Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser 
        35                  40                  45              


Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Ser Cys Gly Ser Ser Ser 
    50                  55                  60                  


Gly Gly Cys Cys Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser His His 
65                  70                  75                  80  


Arg Arg Arg Arg Ser His Cys His Arg Pro Gln Ser Ser Gly Cys Cys 
                85                  90                  95      


Ser Gln Pro Ser Gly Gly Ser Ser Cys Cys Gly Gly Gly Ser Gly Gln 
            100                 105                 110         


His Ser Gly Gly Cys Cys 
        115             


<210>  6665
<211>  333
<212>  DNA
<213>  Homosapiens

<400>  6665
atgtcctgcc agcagagcca gcagcagtgc cagccccctc ccaagtgcac ccccaagtgc     60

cctcccaagt gccccactcc taagtgcccc ccaaagtgtc cccctaagtg ccctccagtc    120

tcttcctgct gcagtgtcag ctccggaggc tgctgtggct ccagctctgg gggcggctgc    180

agctctgggg gaggtggctg ctgcctgagc caccacaggc gccacaggtc ccaccgtcac    240

agactccaga gctctggctg ctgcagccag ccctcgggag gctccagctg ctgtggaggg    300

gacagcggcc agcactctgg aggctgctgc tga                                 333


<210>  6666
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  6666

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Pro Pro Lys Cys Pro Thr Pro Lys Cys Pro Pro Lys 
            20                  25                  30          


Cys Pro Pro Lys Cys Pro Pro Val Ser Ser Cys Cys Ser Val Ser Ser 
        35                  40                  45              


Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Gly Cys Ser Ser Gly Gly 
    50                  55                  60                  


Gly Gly Cys Cys Leu Ser His His Arg Arg His Arg Ser His Arg His 
65                  70                  75                  80  


Arg Leu Gln Ser Ser Gly Cys Cys Ser Gln Pro Ser Gly Gly Ser Ser 
                85                  90                  95      


Cys Cys Gly Gly Asp Ser Gly Gln His Ser Gly Gly Cys Cys 
            100                 105                 110 


<210>  6667
<211>  627
<212>  DNA
<213>  Homosapiens

<400>  6667
gactcctcct gggataactt gtccacacat cttccactag ggtaaggcta cttctggctg     60

aggagacact tggatgtagc tcaagtgctg cttaggcagt cctgatctct cctctcgtct    120

cttcccaggg agctgaaaag ccagattcga cctggtagcc aagcaatgtc acagcagaag    180

cagcaatctt ggaagcctcc aaatgttccc aaatgctccc ctccccaaag atcaaacccc    240

tgcctagctc cctactcgac tccttgtggt gctccccatt cagaaggttg tcattccagt    300

tcccaaaggc ctgaggttca gaagcctagg agggctcgtc aaaagctgcg ctgcctaagt    360

aggggcacaa cctaccactg caaagaggaa gagtgtgaag gcgactgagc ccagaagagt    420

tgaggcacag gtgcagttac tctctccctg ccccaccttt gggtactaat tcccccttgg    480

aaagccaggc cctcaacctc tcatttggac tgagaaacac ttcctgatcc ccagctctag    540

agaagcgaga actaggctga gccacgctgc tactgctctc ttccattcac cccttcagct    600

cagcaacaat aaagctgctt tacttgg                                        627


<210>  6668
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  6668

Met Ser Gln Gln Lys Gln Gln Ser Trp Lys Pro Pro Asn Val Pro Lys 
1               5                   10                  15      


Cys Ser Pro Pro Gln Arg Ser Asn Pro Cys Leu Ala Pro Tyr Ser Thr 
            20                  25                  30          


Pro Cys Gly Ala Pro His Ser Glu Gly Cys His Ser Ser Ser Gln Arg 
        35                  40                  45              


Pro Glu Val Gln Lys Pro Arg Arg Ala Arg Gln Lys Leu Arg Cys Leu 
    50                  55                  60                  


Ser Arg Gly Thr Thr Tyr His Cys Lys Glu Glu Glu Cys Glu Gly Asp 
65                  70                  75                  80  


<210>  6669
<211>  776
<212>  DNA
<213>  Homosapiens

<400>  6669
ggttcagaag gctttggctt ctgatagtca tggactcact aggctgctga ggaagatcaa     60

taatacctac tggaatcagt catgagaagt caagcatgga aattgtgaat tgtgtgtgtg    120

gccagaccag tacctccaag tgttcagaag atgtgtgacc agacaaaaca cagtaaatgc    180

tgcccagcaa aaggcaatca atgctgccca ccacagcaga accagtgctg ccagtcaaaa    240

ggcaatcaat gctgcccacc aaaacagaac cagtgctgcc agccaaaagg cagtcaatgc    300

tgcccaccaa aacacaatca ctgctgccag ccaaaacccc catgctgcat tcaggccagg    360

tgctgtggtt tggagaccaa gcctgaagtc tcacccctta acatggagtc tgagcccaac    420

tcaccgcaaa ctcaggacaa gggctgtcaa acccagcagc agccccatag cccacaaaat    480

gagtccaggc caagcaaatg agagcagaag aagtcaaaca aagaagaagt ccctggggcc    540

atgcctttca ctttgtaggg tgggggatta ctgagagtca ggctagacct gtgtttagag    600

aagcagtttt cacagtgact accatttcca cccaatgaga ggctcctatt tcccatcata    660

gctccctacc ctagggaggc ctccatctgg aaatgggagg atgaagaggc tagaatcatc    720

tttcctagtg atcctgacat ttagacagca cagaaataaa gagcaataaa aagaac        776


<210>  6670
<211>  116
<212>  PRT
<213>  Homosapiens

<400>  6670

Met Cys Asp Gln Thr Lys His Ser Lys Cys Cys Pro Ala Lys Gly Asn 
1               5                   10                  15      


Gln Cys Cys Pro Pro Gln Gln Asn Gln Cys Cys Gln Ser Lys Gly Asn 
            20                  25                  30          


Gln Cys Cys Pro Pro Lys Gln Asn Gln Cys Cys Gln Pro Lys Gly Ser 
        35                  40                  45              


Gln Cys Cys Pro Pro Lys His Asn His Cys Cys Gln Pro Lys Pro Pro 
    50                  55                  60                  


Cys Cys Ile Gln Ala Arg Cys Cys Gly Leu Glu Thr Lys Pro Glu Val 
65                  70                  75                  80  


Ser Pro Leu Asn Met Glu Ser Glu Pro Asn Ser Pro Gln Thr Gln Asp 
                85                  90                  95      


Lys Gly Cys Gln Thr Gln Gln Gln Pro His Ser Pro Gln Asn Glu Ser 
            100                 105                 110         


Arg Pro Ser Lys 
        115     


<210>  6671
<211>  617
<212>  DNA
<213>  Homosapiens

<400>  6671
cttctgatag tcatggactc actaggctgc tgaggaagat caataatacc tactggaatc     60

agtcatgaga agtcaagcat ggaaattgtg aattgtgtgt gtggccagac cagtacctcc    120

aagtgttcag aagatgtgtg accagacaaa acacagtaaa tgctgcccag caaaaggcaa    180

tcaatgctgc ccaccacagc agaaccagtg ctgccagtca aaaggcaatc aatgctgccc    240

accaaaacag aaccagtgct gccagccaaa aggcagtcaa tgctgcccac caaaacacaa    300

tcactgctgc caccccatag cccacaaaat gagtccaggc caagcaaatg agagcagaag    360

aagtcaaaca aagaagaagt ccctggggcc atgcctttca ctttgtaggg tgggggatta    420

ctgagagtca ggctagacct gtgtttagag aagcagtttt cacagtgact accatttcca    480

cccaatgaga ggctcctatt tcccatcata gctccctacc ctagggaggc ctccatctgg    540

aaatgggagg atgaagaggc tagaatcatc tttcctagtg atcctgacat ttagacagca    600

cagaaataaa gagcaat                                                   617


<210>  6672
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  6672

Met Cys Asp Gln Thr Lys His Ser Lys Cys Cys Pro Ala Lys Gly Asn 
1               5                   10                  15      


Gln Cys Cys Pro Pro Gln Gln Asn Gln Cys Cys Gln Ser Lys Gly Asn 
            20                  25                  30          


Gln Cys Cys Pro Pro Lys Gln Asn Gln Cys Cys Gln Pro Lys Gly Ser 
        35                  40                  45              


Gln Cys Cys Pro Pro Lys His Asn His Cys Cys His Pro Ile Ala His 
    50                  55                  60                  


Lys Met Ser Pro Gly Gln Ala Asn Glu Ser Arg Arg Ser Gln Thr Lys 
65                  70                  75                  80  


Lys Lys Ser Leu Gly Pro Cys Leu Ser Leu Cys Arg Val Gly Asp Tyr 
                85                  90                  95      


<210>  6673
<211>  657
<212>  DNA
<213>  Homosapiens

<400>  6673
tgctctggga gctccagctg cccctcctgc tgctctggga gctccagctg cccctcctgc     60

tgctccgggt gcttcagctg tccctcctgc tgctctaggt gcttcaggtg cccctcctgc    120

tgctctggga gctccaacag ttgctctttc ttcattccca gttgctcatc tctcttgact    180

agctcttgat ccagttgctg gtctaagagc ttcttctctt cttccagctg tttgtttagc    240

tgctgatccc tttgtgtttt ctcctgctta agctgctgct ctgggttttc tgctttctga    300

tattcctcat gctgttccca gtgctgttgc tgcagctcct gctcctgtgg ctccttctgc    360

tgttgctcac attcttgctc aggcagtccc tttacagcag tcatgtgctt ttcctcttgc    420

tttgatggga cctccactgg gagctcgaca ggcaccttct ggcatggggg aggcagtgga    480

gttggctgtt tcatttgctc ctgatgggta ttgactggag gaggaacagt cttgaggagc    540

tcctgactga gggcagggga gagggtcact ggcagtgtgt gttgctggga catcttagaa    600

gctactgtca accagactca cagtaaggct gaggcagagg ctttggtgga gtgctga       657


<210>  6674
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  6674

Met Gly Ile Asp Trp Arg Arg Asn Ser Leu Glu Glu Leu Leu Thr Glu 
1               5                   10                  15      


Gly Arg Gly Glu Gly His Trp Gln Cys Val Leu Leu Gly His Leu Arg 
            20                  25                  30          


Ser Tyr Cys Gln Pro Asp Ser Gln 
        35                  40  


<210>  6675
<211>  2108
<212>  DNA
<213>  Homosapiens

<400>  6675
ggttgacagt agcttctaag atgtcccagc aacacacact gccagtgacc ctctcccctg     60

ccctcagtca ggagctcctc aagactgttc ctcctccagt caatacccat caggagcaaa    120

tgaaacagcc aactccactg cctcccccat gccagaaggt gcctgtcgag ctcccagtgg    180

aggtcccatc aaagcaagag gaaaagcaca tgactgctgt aaagggactg cctgagcaag    240

aatgtgagca acagcagaag gagccacagg agcaggagct gcagcaacag cactgggaac    300

agcatgagga atatcagaaa gcagaaaacc cagagcagca gcttaagcag gagaaaacac    360

aaagggatca gcagctaaac aaacagctgg aagaagagaa gaagctctta gaccagcaac    420

tggatcaaga gctagtcaag agagatgagc aactgggaat gaagaaagag caactgttgg    480

agctcccaga gcagcaggag gggcacctga agcacctaga gcagcaggag ggacagctga    540

agcacccgga gcagcaggag gggcagctgg agctcccaga gcagcaggag gggcagctgg    600

agctcccaga gcagcaggag gggcagctgg agctcccaga gcagcaggag gggcagctgg    660

agctcccaga gcagcaggag gggcagctgg agctcccaga gcagcaggag gggcagctgg    720

agctcccaca gcagcaggag gggcagctgg agctctctga gcagcaggag gggcagctgg    780

agctctctga gcagcaggag ggacagctga agcacctgga gcaccaggag gggcagctgg    840

aggtcccaga ggagcagatg gggcagctga agtacctgga acagcaggag gggcagctga    900

agcacctgga tcagcaggag aagcagccag agctcccaga gcagcagatg gggcagctga    960

agcacctgga gcagcaggag gggcagccta agcatctgga gcagcaggag gggcaactgg   1020

agcagctgga ggagcaggag gggcagctga agcacctgga gcagcaggag gggcagctgg   1080

agcacctgga gcaccaggaa gggcagctgg ggctcccaga gcagcaggtg ctgcagctga   1140

agcagctaga gaagcagcag gggcagccaa agcacctgga ggaggaggag gggcagctga   1200

agcacctggt gcagcaggag gggcagctga agcatctggt gcagcaggag gggcagctgg   1260

agcagcagga gaggcaggtg gagcacctgg agcagcaggt ggggcagctg aagcacctag   1320

aggagcagga gggacaactg aagcatctgg agcagcagca ggggcagttg gaggtcccag   1380

agcagcaggt ggggcagcca aagaacctgg agcaggagga gaagcaactg gagctcccag   1440

agcagcaaga gggccaggtg aagcacctgg agaagcagga ggcacagctg gagctcccag   1500

agcagcaggt aggacagcca aagcacctgg aacagcagga aaagcaccta gagcacccag   1560

agcagcagga cggacaacta aaacatctgg agcagcagga ggggcagctg aaggacctgg   1620

agcagcagaa ggggcagctg gagcagcctg tgtttgcccc agctccaggc caggtccaag   1680

acattcaacc agccctgccc acaaagggag aagtattgct tcctgtagag caccagcagc   1740

agaagcagga ggtgcagtgg ccacccaaac ataaataacc acccgcagtg tccagaggcc   1800

ctcagatcgt ctcatacaag ggaagagaga gccactggct ccacttattt cgggtccgct   1860

aggtggcccg tctcatctgt gaacttgact ctgtccctct acatgtctct ttaatggggt   1920

gagggtgggg gagagaggga attattgtcc agtgccaacc ccaatgaccc caatcccaac   1980

ctcaggtgag cagagcctct acttgaggga ctattgttac tataggaatc cttacttccc   2040

cagtattgaa gctgaatcag tgagtgtgta caatgataca taataaatcc tggaagtctt   2100

gggatcct                                                            2108


<210>  6676
<211>  585
<212>  PRT
<213>  Homosapiens

<400>  6676

Met Ser Gln Gln His Thr Leu Pro Val Thr Leu Ser Pro Ala Leu Ser 
1               5                   10                  15      


Gln Glu Leu Leu Lys Thr Val Pro Pro Pro Val Asn Thr His Gln Glu 
            20                  25                  30          


Gln Met Lys Gln Pro Thr Pro Leu Pro Pro Pro Cys Gln Lys Val Pro 
        35                  40                  45              


Val Glu Leu Pro Val Glu Val Pro Ser Lys Gln Glu Glu Lys His Met 
    50                  55                  60                  


Thr Ala Val Lys Gly Leu Pro Glu Gln Glu Cys Glu Gln Gln Gln Lys 
65                  70                  75                  80  


Glu Pro Gln Glu Gln Glu Leu Gln Gln Gln His Trp Glu Gln His Glu 
                85                  90                  95      


Glu Tyr Gln Lys Ala Glu Asn Pro Glu Gln Gln Leu Lys Gln Glu Lys 
            100                 105                 110         


Thr Gln Arg Asp Gln Gln Leu Asn Lys Gln Leu Glu Glu Glu Lys Lys 
        115                 120                 125             


Leu Leu Asp Gln Gln Leu Asp Gln Glu Leu Val Lys Arg Asp Glu Gln 
    130                 135                 140                 


Leu Gly Met Lys Lys Glu Gln Leu Leu Glu Leu Pro Glu Gln Gln Glu 
145                 150                 155                 160 


Gly His Leu Lys His Leu Glu Gln Gln Glu Gly Gln Leu Lys His Pro 
                165                 170                 175     


Glu Gln Gln Glu Gly Gln Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln 
            180                 185                 190         


Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln Leu Glu Leu Pro Glu Gln 
        195                 200                 205             


Gln Glu Gly Gln Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln Leu Glu 
    210                 215                 220                 


Leu Pro Glu Gln Gln Glu Gly Gln Leu Glu Leu Pro Gln Gln Gln Glu 
225                 230                 235                 240 


Gly Gln Leu Glu Leu Ser Glu Gln Gln Glu Gly Gln Leu Glu Leu Ser 
                245                 250                 255     


Glu Gln Gln Glu Gly Gln Leu Lys His Leu Glu His Gln Glu Gly Gln 
            260                 265                 270         


Leu Glu Val Pro Glu Glu Gln Met Gly Gln Leu Lys Tyr Leu Glu Gln 
        275                 280                 285             


Gln Glu Gly Gln Leu Lys His Leu Asp Gln Gln Glu Lys Gln Pro Glu 
    290                 295                 300                 


Leu Pro Glu Gln Gln Met Gly Gln Leu Lys His Leu Glu Gln Gln Glu 
305                 310                 315                 320 


Gly Gln Pro Lys His Leu Glu Gln Gln Glu Gly Gln Leu Glu Gln Leu 
                325                 330                 335     


Glu Glu Gln Glu Gly Gln Leu Lys His Leu Glu Gln Gln Glu Gly Gln 
            340                 345                 350         


Leu Glu His Leu Glu His Gln Glu Gly Gln Leu Gly Leu Pro Glu Gln 
        355                 360                 365             


Gln Val Leu Gln Leu Lys Gln Leu Glu Lys Gln Gln Gly Gln Pro Lys 
    370                 375                 380                 


His Leu Glu Glu Glu Glu Gly Gln Leu Lys His Leu Val Gln Gln Glu 
385                 390                 395                 400 


Gly Gln Leu Lys His Leu Val Gln Gln Glu Gly Gln Leu Glu Gln Gln 
                405                 410                 415     


Glu Arg Gln Val Glu His Leu Glu Gln Gln Val Gly Gln Leu Lys His 
            420                 425                 430         


Leu Glu Glu Gln Glu Gly Gln Leu Lys His Leu Glu Gln Gln Gln Gly 
        435                 440                 445             


Gln Leu Glu Val Pro Glu Gln Gln Val Gly Gln Pro Lys Asn Leu Glu 
    450                 455                 460                 


Gln Glu Glu Lys Gln Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln Val 
465                 470                 475                 480 


Lys His Leu Glu Lys Gln Glu Ala Gln Leu Glu Leu Pro Glu Gln Gln 
                485                 490                 495     


Val Gly Gln Pro Lys His Leu Glu Gln Gln Glu Lys His Leu Glu His 
            500                 505                 510         


Pro Glu Gln Gln Asp Gly Gln Leu Lys His Leu Glu Gln Gln Glu Gly 
        515                 520                 525             


Gln Leu Lys Asp Leu Glu Gln Gln Lys Gly Gln Leu Glu Gln Pro Val 
    530                 535                 540                 


Phe Ala Pro Ala Pro Gly Gln Val Gln Asp Ile Gln Pro Ala Leu Pro 
545                 550                 555                 560 


Thr Lys Gly Glu Val Leu Leu Pro Val Glu His Gln Gln Gln Lys Gln 
                565                 570                 575     


Glu Val Gln Trp Pro Pro Lys His Lys 
            580                 585 


<210>  6677
<211>  2236
<212>  DNA
<213>  Homosapiens

<400>  6677
ggttgacagt agcttctaag atgtcccagc aacacacact gccagtgacc ctctcccctg     60

ccctcagtca ggagctcctc aagactgttc ctcctccagt caatacccat caggagcaaa    120

tgaaacagcc aactccactg cctcccccat gccagaaggt gcctgtcgag ctcccagtgg    180

aggtcccatc aaagcaagag gaaaagcaca tgactgctgt aaagggactg cctgagcaag    240

aatgtgagca acagcagaag gagccacagg agcaggagct gcagcaacag cactgggaac    300

agcatgagga atatcagaaa gcagaaaacc cagagcagca gcttaagcag gagaaaacac    360

aaagggatca gcagctaaac aaacagctgg aagaagagaa gaagctctta gaccagcaac    420

tggatcaaga gctagtcaag agagatgagc aactgggaat gaagaaagag caactgttgg    480

agctcccaga gcagcaggag gggcacctga agcacctaga gcagcaggag ggacagctga    540

agcacccgga gcagcaggag gggcagctgg agctcccaga gcagcaggag gggcagctgg    600

agctcccaga gcagcaggag gggcagctgg agctcccaga gcagcaggag gggcagctgg    660

agctcccaga gcagcaggag gggcagctgg agctcccaga gcagcaggag gggcagctgg    720

agctcccaca gcagcaggag gggcagctgg agctctctga gcagcaggag gggcagctgg    780

agctctctga gcagcaggag ggacagctga agcacctgga gcaccaggag gggcagctgg    840

aggtcccaga ggagcagatg gggcagctga agtacctgga acagcaggag gggcagctga    900

agcacctgga tcagcaggag aagcagccag agctcccaga gcagcagatg gggcagctga    960

agcacctgga gcagcaggag gggcagccta agcatctgga gcagcaggag gggcaactgg   1020

agcagctgga ggagcaggag gggcagctga agcacctgga gcagcaggag gggcagctgg   1080

agcacctgga gcaccaggaa gggcagctgg ggctcccaga gcagcaggtg ctgcagctga   1140

agcagctaga gaagcagcag gggcagccaa agcacctgga ggaggaggag gggcagctga   1200

agcacctggt gcagcaggag gggcagctga agcatctggt gcagcaggag gggcagctgg   1260

agcagcagga gaggcaggtg gagcacctgg agcagcaggt ggggcagctg aagcacctag   1320

aggagcagga gggacaactg aagcatctgg agcagcagca ggggcagttg gaggtcccag   1380

agcagcaggt ggggcagcca aagaacctgg agcaggagga gaagcaactg gagctcccag   1440

agcagcaaga gggccaggtg aagcacctgg agaagcagga ggcacagctg gagctcccag   1500

agcagcaggt aggacagcca aagcacctgg aacagcagga aaagcaccta gagcacccag   1560

agcagcagga cggacaacta aaacatctgg agcagcagga ggggcagctg aaggacctgg   1620

agcagcagaa ggggcagctg gagcagcctg tgtttgcccc agctccaggc caggtccaag   1680

acattcaacc agccctgccc acaaagggag aagtattgct tcctgtagag caccagcagc   1740

agaagcagga ggtgcagtgg ccacccaaac ataaataacc acccgcagtg tccagaggcc   1800

ctcagatcgt ctcatacaag ggaagagaga gccactggct ccacttattt cgggtccgct   1860

aggtggcccg tctcatctgt gaacttgact ctgtccctct acatgtctct ttaatggggt   1920

gagggtgggg gagagaggga attattgtcc agtgccaacc ccaatgaccc caatcccaac   1980

ctcaggtgag cagagcctct acttgaggga ctattgttac tataggaatc cttacttccc   2040

cagtattgaa gctgaatcag tgagtgtgta caatgataca taataaatcc tggaagtctt   2100

gggatcctat attctcttta gcattttctt ctatcacacc acataaaaac ctgtgtatgg   2160

gtcaatggct gcaagagact cccacggccc attctcaaag gaggacagac tctttttaaa   2220

ttttggtcct caaacc                                                   2236


<210>  6678
<211>  585
<212>  PRT
<213>  Homosapiens

<400>  6678

Met Ser Gln Gln His Thr Leu Pro Val Thr Leu Ser Pro Ala Leu Ser 
1               5                   10                  15      


Gln Glu Leu Leu Lys Thr Val Pro Pro Pro Val Asn Thr His Gln Glu 
            20                  25                  30          


Gln Met Lys Gln Pro Thr Pro Leu Pro Pro Pro Cys Gln Lys Val Pro 
        35                  40                  45              


Val Glu Leu Pro Val Glu Val Pro Ser Lys Gln Glu Glu Lys His Met 
    50                  55                  60                  


Thr Ala Val Lys Gly Leu Pro Glu Gln Glu Cys Glu Gln Gln Gln Lys 
65                  70                  75                  80  


Glu Pro Gln Glu Gln Glu Leu Gln Gln Gln His Trp Glu Gln His Glu 
                85                  90                  95      


Glu Tyr Gln Lys Ala Glu Asn Pro Glu Gln Gln Leu Lys Gln Glu Lys 
            100                 105                 110         


Thr Gln Arg Asp Gln Gln Leu Asn Lys Gln Leu Glu Glu Glu Lys Lys 
        115                 120                 125             


Leu Leu Asp Gln Gln Leu Asp Gln Glu Leu Val Lys Arg Asp Glu Gln 
    130                 135                 140                 


Leu Gly Met Lys Lys Glu Gln Leu Leu Glu Leu Pro Glu Gln Gln Glu 
145                 150                 155                 160 


Gly His Leu Lys His Leu Glu Gln Gln Glu Gly Gln Leu Lys His Pro 
                165                 170                 175     


Glu Gln Gln Glu Gly Gln Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln 
            180                 185                 190         


Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln Leu Glu Leu Pro Glu Gln 
        195                 200                 205             


Gln Glu Gly Gln Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln Leu Glu 
    210                 215                 220                 


Leu Pro Glu Gln Gln Glu Gly Gln Leu Glu Leu Pro Gln Gln Gln Glu 
225                 230                 235                 240 


Gly Gln Leu Glu Leu Ser Glu Gln Gln Glu Gly Gln Leu Glu Leu Ser 
                245                 250                 255     


Glu Gln Gln Glu Gly Gln Leu Lys His Leu Glu His Gln Glu Gly Gln 
            260                 265                 270         


Leu Glu Val Pro Glu Glu Gln Met Gly Gln Leu Lys Tyr Leu Glu Gln 
        275                 280                 285             


Gln Glu Gly Gln Leu Lys His Leu Asp Gln Gln Glu Lys Gln Pro Glu 
    290                 295                 300                 


Leu Pro Glu Gln Gln Met Gly Gln Leu Lys His Leu Glu Gln Gln Glu 
305                 310                 315                 320 


Gly Gln Pro Lys His Leu Glu Gln Gln Glu Gly Gln Leu Glu Gln Leu 
                325                 330                 335     


Glu Glu Gln Glu Gly Gln Leu Lys His Leu Glu Gln Gln Glu Gly Gln 
            340                 345                 350         


Leu Glu His Leu Glu His Gln Glu Gly Gln Leu Gly Leu Pro Glu Gln 
        355                 360                 365             


Gln Val Leu Gln Leu Lys Gln Leu Glu Lys Gln Gln Gly Gln Pro Lys 
    370                 375                 380                 


His Leu Glu Glu Glu Glu Gly Gln Leu Lys His Leu Val Gln Gln Glu 
385                 390                 395                 400 


Gly Gln Leu Lys His Leu Val Gln Gln Glu Gly Gln Leu Glu Gln Gln 
                405                 410                 415     


Glu Arg Gln Val Glu His Leu Glu Gln Gln Val Gly Gln Leu Lys His 
            420                 425                 430         


Leu Glu Glu Gln Glu Gly Gln Leu Lys His Leu Glu Gln Gln Gln Gly 
        435                 440                 445             


Gln Leu Glu Val Pro Glu Gln Gln Val Gly Gln Pro Lys Asn Leu Glu 
    450                 455                 460                 


Gln Glu Glu Lys Gln Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln Val 
465                 470                 475                 480 


Lys His Leu Glu Lys Gln Glu Ala Gln Leu Glu Leu Pro Glu Gln Gln 
                485                 490                 495     


Val Gly Gln Pro Lys His Leu Glu Gln Gln Glu Lys His Leu Glu His 
            500                 505                 510         


Pro Glu Gln Gln Asp Gly Gln Leu Lys His Leu Glu Gln Gln Glu Gly 
        515                 520                 525             


Gln Leu Lys Asp Leu Glu Gln Gln Lys Gly Gln Leu Glu Gln Pro Val 
    530                 535                 540                 


Phe Ala Pro Ala Pro Gly Gln Val Gln Asp Ile Gln Pro Ala Leu Pro 
545                 550                 555                 560 


Thr Lys Gly Glu Val Leu Leu Pro Val Glu His Gln Gln Gln Lys Gln 
                565                 570                 575     


Glu Val Gln Trp Pro Pro Lys His Lys 
            580                 585 


<210>  6679
<211>  1984
<212>  DNA
<213>  Homosapiens

<400>  6679
ggaagcgtgg taggagaaga tgcctgtgca tgccgctcat gtttccagca gggcaatgta     60

gatgcatgtc aggaaagatg attagatagt ttagaaccag atccttgtct gagatggaaa    120

ctgcagctgc taattaagaa gagtagagct cgaggaagcc gccagctgcc agcctggtgc    180

tgcctctcct gcaagtgtga agtgtggctg catccagaag cactgaaaat aattgattag    240

aaagagaaag agactgaaaa tgtcataaat gaggagataa ttggagaaaa tcattgtgaa    300

gaggtatgaa tggatggcaa cacaaatgga gtaagactta aagagatata agcctaccaa    360

atgctgacat gatttttgtg agttgtgaag atttaaagaa atctgtttga ataacaattt    420

ttgaggctac ctataaattt gtgttcatta cttccactaa gcaaggttct tttgattatt    480

ctttgatcat tgaaatgttt tatattttat ttaatttaca gcaacaaaaa taactcttga    540

gaagaaataa atgtgaacct atggagataa ttatttagta atgtttgaaa tatatgattt    600

agaacatttc attgcactta ttaatgagta taagaatatt atgaaaacag aaaaataatg    660

agccttgtaa gagttcacac aattatttta tgtaattggt attctatatt caaggagagc    720

ttgaatgcag aaattaaaga agcatatgct catttgaaaa gagacaaatc tagtagtgta    780

attaaagctt gtgccttata acacaataaa aatattcaga aggattttat ccttaattgt    840

gacataaaat gatttctaac ctttattttt tgagtcagaa aaaacggagg aagcatgggt    900

tcttctttgc tatatgaaat caaagtaact ttacaaattt gaagtgctta gttatctaaa    960

atcatatcat ggaaagatat atatttatat tttgattgtt ttatgtatgt aactttttaa   1020

agatcagagt gatctgggca agaaaccagt gctatcagcc agtattgcat tttgtttaca   1080

tgtaatagaa atccaactaa acaaggattt tattttcatc atgttacaga aagttaggat   1140

ataggaagtc cttccttgta gttgctcaag gaaatcatga aggaccaagt ttattctagc   1200

ttcctgctct gccaccttta gcaagtggac agtcccccta cctctcatag gcaatgaact   1260

tcttcatatc caagcatgtg cttagggcag aagaaaggga ttggtgagaa caaaaatcac   1320

atgccagtga agtctgttca tcttatatta ggaaataata gctcctgcaa atgtcttact   1380

tgataggctt ctaccactgg aactgcctca catgactacc actagataga atggaatctg   1440

gcttgatgag tatttttaag tggatacatt tacttcctaa acaaaaccaa tattctatta   1500

ataaaagaga aaggaagaaa gattcttgta aggcagctaa tatttctgtc acacagagaa   1560

aaacaaattg ataatgcagt acaaggttga tattttaagg tagagatttt tagcttgagc   1620

atttagcatc catttgttct tttaatgtaa atgtcaaaca aaatacaaaa atcgtatgta   1680

taattaccaa aaactattta aaagtaaatt tataattcac tcaatagagt aatatagatt   1740

aaataatttt tgtaaaattt aacgtgtttt tgctttcaaa aaatacaaaa gataaaaaaa   1800

gaatatacag ctaaacagtc tatatggaaa aaaccataaa agtgtcaaaa gtaagatgat   1860

ggcttatgaa aattacattt ttacatttat ggatgtgacc tgaatgtaaa tgtaagtaaa   1920

ttgtaaatgt attataaatg aatgtaaaaa ccaaaataaa gttgtttatt ggcaagattg   1980

attt                                                                1984


<210>  6680
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  6680

Met Ser Leu Val Arg Val His Thr Ile Ile Leu Cys Asn Trp Tyr Ser 
1               5                   10                  15      


Ile Phe Lys Glu Ser Leu Asn Ala Glu Ile Lys Glu Ala Tyr Ala His 
            20                  25                  30          


Leu Lys Arg Asp Lys Ser Ser Ser Val Ile Lys Ala Cys Ala Leu 
        35                  40                  45          


<210>  6681
<211>  766
<212>  DNA
<213>  Homosapiens

<400>  6681
aagggctcag cctcctctcc tggggtccag cttgtcgcct ctggctcacc tgttcctaga     60

gcaatgtctt cccagcagca gcagcggcag cagcagcagt gcccacccca gagggcccag    120

cagcagcaag tgaagcagcc ttgtcagcca ccccctgtta aatgtcaaga gacatgtgca    180

cccaaaacca aggatccatg tgctccccag gtcaagaagc aatgcccacc gaaaggcacc    240

atcattccag cccagcagaa gtgtccctca gcccagcaag cctccaagag caaacagaag    300

taaggatgga ctggatatta ccatcatcca ccatcctggc taccagatgg aaccttctct    360

tcttccttct cctcttccct ccagctcttg agcctaccct cctctcacat ctcctcctgc    420

ccaagatgta aggaagcatt gtaaggattt cttcccatcg tacccttccc cacacatacc    480

accttggctt cttctatatc ccaccccgat gctctcccag gtgggtgtga gagagacctc    540

attctctgca ggctccagcg tggccacagc taaggcccat ccatttccca aagtgaggaa    600

agtgtctggg cttcttctgg ggttccaccc tgacaagtag ggtcacagag gctggtgcac    660

agtttctgcc tcattcctct ccatgatgcc ccctgctctg ggcttctctc ctgttttccc    720

caataaatat gtgcctcatg taataaatgt gtctgcttcc tgggct                   766


<210>  6682
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  6682

Met Ser Arg Asp Met Cys Thr Gln Asn Gln Gly Ser Met Cys Ser Pro 
1               5                   10                  15      


Gly Gln Glu Ala Met Pro Thr Glu Arg His His His Ser Ser Pro Ala 
            20                  25                  30          


Glu Val Ser Leu Ser Pro Ala Ser Leu Gln Glu Gln Thr Glu Val Arg 
        35                  40                  45              


Met Asp Trp Ile Leu Pro Ser Ser Thr Ile Leu Ala Thr Arg Trp Asn 
    50                  55                  60                  


Leu Leu Phe Phe Leu Leu Leu Phe Pro Pro Ala Leu Glu Pro Thr Leu 
65                  70                  75                  80  


Leu Ser His Leu Leu Leu Pro Lys Met 
                85                  


<210>  6683
<211>  650
<212>  DNA
<213>  Homosapiens

<400>  6683
accaaaccca agggaccaca cagcccattc tgctccgtat accagaaaaa aacacatttg     60

aagcatgaat tctcagcagc agaagcagcc ttgcacccca ccccctcagc ctcagcagca    120

gcaggtgaaa caaccttgcc agcctccacc ccaggaacca tgcatcccca aaaccaagga    180

gccctgccac cccaaggtgc ctgagccctg ccaccccaaa gtgcctgagc cctgccagcc    240

caaggttcca gagccctgcc agcccaaggt gcctgagccc tgcccttcaa cggtcactcc    300

agcaccagcc cagcagaaga ccaagcagaa gtaatgtggt ccacagccat gcccttgagg    360

agctggccac tggatactga acaccctact ccattctgct tatgaatccc atttgcctat    420

tgaccctgca gttagcatgc tgtcaccctg aatcataatc gctcctttgc acctctaaaa    480

agatgtccct taccctcatt ctggagggct cctgagcctc tgcgtaaggc tgaacgtctc    540

actgactgag ctagtcttct tgttgctcgg gtgcatttga ggatggattt ggggaaggat    600

caagtgaacc atccctagtc ttccttcaat aaataacttt taactccaca               650


<210>  6684
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  6684

Met Asn Ser Gln Gln Gln Lys Gln Pro Cys Thr Pro Pro Pro Gln Pro 
1               5                   10                  15      


Gln Gln Gln Gln Val Lys Gln Pro Cys Gln Pro Pro Pro Gln Glu Pro 
            20                  25                  30          


Cys Ile Pro Lys Thr Lys Glu Pro Cys His Pro Lys Val Pro Glu Pro 
        35                  40                  45              


Cys His Pro Lys Val Pro Glu Pro Cys Gln Pro Lys Val Pro Glu Pro 
    50                  55                  60                  


Cys Gln Pro Lys Val Pro Glu Pro Cys Pro Ser Thr Val Thr Pro Ala 
65                  70                  75                  80  


Pro Ala Gln Gln Lys Thr Lys Gln Lys 
                85                  


<210>  6685
<211>  500
<212>  DNA
<213>  Homosapiens

<400>  6685
accagatccc agaggctgaa cacctcgacc ttctctgcac agcagattac aggtgtggaa     60

cttaggatca gaaaagggga gtgatttctg taaaggcttg ctaagttagc aagacaatat    120

acccacttca agagcactct cctgtcaaca tgtattgaaa atttttaata tagaaggcac    180

tacattggca attttgatga tcaaaagata agtttttctt tattgcatga atgtataatc    240

cattagaaaa catatacttg actaaaattt gcaaacatac agcatgggga gtgattagca    300

gagagggaaa gcaagtatca tgctgtggca aaacgaggaa ggtgagagca tcaggaagga    360

cagccatgag aggtgggcat gtgtggggag gcagcgatga tgtggagagc ctgccagaga    420

gcatgtgcag caggcacagt gtgaacagag gctcccaggt ggattgtggg agccttaggg    480

ggaagtttag ataagagttc                                                500


<210>  6686
<211>  87
<212>  PRT
<213>  Homosapiens

<400>  6686

Met Tyr Asn Pro Leu Glu Asn Ile Tyr Leu Thr Lys Ile Cys Lys His 
1               5                   10                  15      


Thr Ala Trp Gly Val Ile Ser Arg Glu Gly Lys Gln Val Ser Cys Cys 
            20                  25                  30          


Gly Lys Thr Arg Lys Val Arg Ala Ser Gly Arg Thr Ala Met Arg Gly 
        35                  40                  45              


Gly His Val Trp Gly Gly Ser Asp Asp Val Glu Ser Leu Pro Glu Ser 
    50                  55                  60                  


Met Cys Ser Arg His Ser Val Asn Arg Gly Ser Gln Val Asp Cys Gly 
65                  70                  75                  80  


Ser Leu Arg Gly Lys Phe Arg 
                85          


<210>  6687
<211>  987
<212>  DNA
<213>  Homosapiens

<400>  6687
accagatccc agaggctgaa cacctcgacc ttctctgcac agcagatgat ccctgagcag     60

ctgaagacca gaaaagccac taagactttc tgcttaattc aggagcttag aggattcttc    120

aaagagtgtg tccagcatcc tttgaagcat gagttcttac cagcagaagc agacctttac    180

cccaccacct cagcttcaac agcagcaggt gaaacaaccc agccagcctc cacctcagga    240

aatatttgtt cccacaacca aggagccatg ccactcaaag gttccacaac ctggaaacac    300

aaagattcca gagccaggct gtaccaaggt ccctgagcca ggctgtacca aggtccctga    360

gccaggctgt accaaggtcc ctgagccagg ttgtaccaag gtccctgagc caggctgtac    420

caaggtccct gagccaggtt gtaccaaggt ccctgagcca ggctacacca aggtccctga    480

accaggcagc atcaaggtcc ctgaccaagg cttcatcaag tttcctgagc caggtgccat    540

caaagttcct gagcaaggat acaccaaagt tcctgtgcca ggctacacaa agctaccaga    600

gccatgtcct tcaacggtca ctccaggccc agctcagcag aagaccaagc agaagtaatt    660

tggtgcacag acaagccctt gagaagccaa ccaccagatg ctggacaccc tcttcccatc    720

tgtttctgtg tcttaattgt ctgtagacct tgtaatcagc acattgtcac cccaagccat    780

agtctctctc ttatttgtat cctaaaaata cgtactataa agcttttgtt cacacacact    840

ctgaagaatc ctgtaagccc ctgaattaag cagaaagtct tcatggcttt tctggtcttc    900

ggctgctcag ggttcatctg aagattcgaa tgaaaagaaa tgcatgtttc ctgctcttcc    960

ctcattaaat tgcttttaat tccagtc                                        987


<210>  6688
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  6688

Met Ile Pro Glu Gln Leu Lys Thr Arg Lys Ala Thr Lys Thr Phe Cys 
1               5                   10                  15      


Leu Ile Gln Glu Leu Arg Gly Phe Phe Lys Glu Cys Val Gln His Pro 
            20                  25                  30          


Leu Lys His Glu Phe Leu Pro Ala Glu Ala Asp Leu Tyr Pro Thr Thr 
        35                  40                  45              


Ser Ala Ser Thr Ala Ala Gly Glu Thr Thr Gln Pro Ala Ser Thr Ser 
    50                  55                  60                  


Gly Asn Ile Cys Ser His Asn Gln Gly Ala Met Pro Leu Lys Gly Ser 
65                  70                  75                  80  


Thr Thr Trp Lys His Lys Asp Ser Arg Ala Arg Leu Tyr Gln Gly Pro 
                85                  90                  95      


<210>  6689
<211>  903
<212>  DNA
<213>  Homosapiens

<400>  6689
accagatccc agaggctgaa cacctcgacc ttctctgcac agcaggtcca gcatcctttg     60

aagcatgagt tcttaccagc agaagcagac ctttacccca ccacctcagc ttcaacagca    120

gcaggtgaaa caacccagcc agcctccacc tcaggaaata tttgttccca caaccaagga    180

gccatgccac tcaaaggttc cacaacctgg aaacacaaag attccagagc caggctgtac    240

caaggtccct gagccaggct gtaccaaggt ccctgagcca ggctgtacca aggtccctga    300

gccaggttgt accaaggtcc ctgagccagg ctgtaccaag gtccctgagc caggttgtac    360

caaggtccct gagccaggct acaccaaggt ccctgaacca ggcagcatca aggtccctga    420

ccaaggcttc atcaagtttc ctgagccagg tgccatcaaa gttcctgagc aaggatacac    480

caaagttcct gtgccaggct acacaaagct accagagcca tgtccttcaa cggtcactcc    540

aggcccagct cagcagaaga ccaagcagaa gtaatttggt gcacagacaa gcccttgaga    600

agccaaccac cagatgctgg acaccctctt cccatctgtt tctgtgtctt aattgtctgt    660

agaccttgta atcagcacat tgtcacccca agccatagtc tctctcttat ttgtatccta    720

aaaatacgta ctataaagct tttgttcaca cacactctga agaatcctgt aagcccctga    780

attaagcaga aagtcttcat ggcttttctg gtcttcggct gctcagggtt catctgaaga    840

ttcgaatgaa aagaaatgca tgtttcctgc tcttccctca ttaaattgct tttaattcca    900

gtc                                                                  903


<210>  6690
<211>  169
<212>  PRT
<213>  Homosapiens

<400>  6690

Met Ser Ser Tyr Gln Gln Lys Gln Thr Phe Thr Pro Pro Pro Gln Leu 
1               5                   10                  15      


Gln Gln Gln Gln Val Lys Gln Pro Ser Gln Pro Pro Pro Gln Glu Ile 
            20                  25                  30          


Phe Val Pro Thr Thr Lys Glu Pro Cys His Ser Lys Val Pro Gln Pro 
        35                  40                  45              


Gly Asn Thr Lys Ile Pro Glu Pro Gly Cys Thr Lys Val Pro Glu Pro 
    50                  55                  60                  


Gly Cys Thr Lys Val Pro Glu Pro Gly Cys Thr Lys Val Pro Glu Pro 
65                  70                  75                  80  


Gly Cys Thr Lys Val Pro Glu Pro Gly Cys Thr Lys Val Pro Glu Pro 
                85                  90                  95      


Gly Cys Thr Lys Val Pro Glu Pro Gly Tyr Thr Lys Val Pro Glu Pro 
            100                 105                 110         


Gly Ser Ile Lys Val Pro Asp Gln Gly Phe Ile Lys Phe Pro Glu Pro 
        115                 120                 125             


Gly Ala Ile Lys Val Pro Glu Gln Gly Tyr Thr Lys Val Pro Val Pro 
    130                 135                 140                 


Gly Tyr Thr Lys Leu Pro Glu Pro Cys Pro Ser Thr Val Thr Pro Gly 
145                 150                 155                 160 


Pro Ala Gln Gln Lys Thr Lys Gln Lys 
                165                 


<210>  6691
<211>  787
<212>  DNA
<213>  Homosapiens

<400>  6691
gactggaatt aaaagcaatt taatgaggga agagcaggaa acatgcattt cttttcattc     60

gaatcttcag atgaaccctg agcagccgaa gaccagaaaa gccatgaaga ctttctgctt    120

aattcagggg cttacaggat tcttcagagt gtgtgtgaac aaaagcttta tagtacgtat    180

ttttaggata caaataagag agagactatg gcttggggtg acaatgtgct gattacaagg    240

tctacagaca attaagacac agaaacagat gggaagaggg tgtccagcat ctggtggttg    300

gcttctcaag ggcttgtctg tgcaccaaat tacttctgct tggtcttctg ctgagctggg    360

cctggagtga ccgttgaagg acatggctct ggtagctttg tgtagcctgg cacaggaact    420

ttggtgtatc cttgctcagg aactttgatg gcacctggct caggaaactt gatgaagcct    480

tggtcaggga ccttgatgct gcctggttca gggaccttgg tgtagcctgg ctcagggacc    540

ttggtacaac ctggctcagg gaccttggta cagcctggct cagggacctt ggtacaacct    600

ggctcaggga ccttggtaca gcctggctct ggaatctttg tgtttccagg ttgtggaacc    660

tttgagtggc atggctcctt ggttgtggga acaaatattt cctgaggtgg aggctggctg    720

ggttgtttca cctgctgctg ttgaagctga ggtggtgggg taaaggtctg cttctgctgg    780

taagaac                                                              787


<210>  6692
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  6692

Met Arg Glu Glu Gln Glu Thr Cys Ile Ser Phe His Ser Asn Leu Gln 
1               5                   10                  15      


Met Asn Pro Glu Gln Pro Lys Thr Arg Lys Ala Met Lys Thr Phe Cys 
            20                  25                  30          


Leu Ile Gln Gly Leu Thr Gly Phe Phe Arg Val Cys Val Asn Lys Ser 
        35                  40                  45              


Phe Ile Val Arg Ile Phe Arg Ile Gln Ile Arg Glu Arg Leu Trp Leu 
    50                  55                  60                  


Gly Val Thr Met Cys 
65                  


<210>  6693
<211>  620
<212>  DNA
<213>  Homosapiens

<400>  6693
caccagttct aagggaccat acagagtatt cctctcttca caccaggacc agtcactgtt     60

gcagcatgag ttcccagcag cagaagcagc cttgcacccc accccctcag cttcagcagc    120

agcaggtgaa acagccttgc cagcctccac ctcaggaacc atgcatcccc aaaaccaagg    180

agccctgcca ccccaaggtg cctgagccct gccaccccaa agtgcccgag ccctgccagc    240

ccaaggttcc agagccatgc caccccaagg tgcctgagcc ctgcccttca atagtcactc    300

cagcaccagc ccagcagaag accaagcaga agtaatgtgg tccacagcca tgcccttgag    360

gagccggcca ccagatgctg aatcccctat cccattctgc gtatgagtcc catttgcctt    420

gcaattagca ttctgtctcc cccaaaaaag aatgtgctat gaagctttct ttcctacaca    480

ctctgagtct ctgaatgaag ctgaaggtct tagtaccaga gctagttttc agctgctcag    540

aattcatctg aagagagact taagatgaaa gcaaatgatt cagctccctt atacccccat    600

taaattcact ttcaattcca                                                620


<210>  6694
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  6694

Met Ser Ser Gln Gln Gln Lys Gln Pro Cys Thr Pro Pro Pro Gln Leu 
1               5                   10                  15      


Gln Gln Gln Gln Val Lys Gln Pro Cys Gln Pro Pro Pro Gln Glu Pro 
            20                  25                  30          


Cys Ile Pro Lys Thr Lys Glu Pro Cys His Pro Lys Val Pro Glu Pro 
        35                  40                  45              


Cys His Pro Lys Val Pro Glu Pro Cys Gln Pro Lys Val Pro Glu Pro 
    50                  55                  60                  


Cys His Pro Lys Val Pro Glu Pro Cys Pro Ser Ile Val Thr Pro Ala 
65                  70                  75                  80  


Pro Ala Gln Gln Lys Thr Lys Gln Lys 
                85                  


<210>  6695
<211>  682
<212>  DNA
<213>  Homosapiens

<400>  6695
aactcctggt actctagcac cgatctgctt tggagaacct gatcctgaga ctccagcagg     60

atgtcttatc aacagcagca gtgcaagcag ccctgccagc cacctcctgt gtgccccacg    120

ccaaagtgcc cagagccatg tccacccccg aagtgccctg agccctgccc atcaccaaag    180

tgtccacagc cctgcccacc tcagcagtgc cagcagaaat atcctcctgt gacaccttcc    240

ccaccctgcc agccaaagtg tccacccaag agcaagtaac agcttcagga ttcatcagga    300

gcatgagagg ataaggataa ttggctcacc tcgttccaca gctccacttg catcttctca    360

ccaaagcctt ccatggatgc acagggagct tctttctcct taacctgtgg cctgcctgtg    420

atgatctgtg acagcaaaag attccctttc tgaggctgcc atactgccac tgtccaggtg    480

gagctaagaa aaggaagtcc tcagctgtgc cagctcccag agcttcggaa gaaagagcag    540

cagctctctc cctgggaacc atcagacaat tctgttgatg tgttctgtgt ctgtctgtca    600

cctggtcatg agcttctacc acctttgcaa ttgtcattta tctttcactc cctgaataaa    660

gtatctatgc atatatattt gt                                             682


<210>  6696
<211>  72
<212>  PRT
<213>  Homosapiens

<400>  6696

Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Ser Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Tyr Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210>  6697
<211>  767
<212>  DNA
<213>  Homosapiens

<400>  6697
caagtagcaa acgtgctgtg gagactagat ctcactctca aatctgtcct gggatgcaag     60

tgcctctacg aatgtggtgc agaagctaca aatgtggtgc agaagacagc ttcaaagagg    120

aaaggaatat agatcctgag actccagcag gatgtcttat caacagcagc agtgcaagca    180

gccctgccag ccacctcctg tgtgccccac gccaaagtgc ccagagccat gtccaccccc    240

gaagtgccct gagccctgcc catcaccaaa gtgtccacag ccctgcccac ctcagcagtg    300

ccagcagaaa tatcctcctg tgacaccttc cccaccctgc cagccaaagt gtccacccaa    360

gagcaagtaa cagcttcagg attcatcagg agcatgagag gataaggata attggctcac    420

ctcgttccac agctccactt gcatcttctc accaaagcct tccatggatg cacagggagc    480

ttctttctcc ttaacctgtg gcctgcctgt gatgatctgt gacagcaaaa gattcccttt    540

ctgaggctgc catactgcca ctgtccaggt ggagctaaga aaaggaagtc ctcagctgtg    600

ccagctccca gagcttcgga agaaagagca gcagctctct ccctgggaac catcagacaa    660

ttctgttgat gtgttctgtg tctgtctgtc acctggtcat gagcttctac cacctttgca    720

attgtcattt atctttcact ccctgaataa agtatctatg catatat                  767


<210>  6698
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  6698

Met Gln Val Pro Leu Arg Met Trp Cys Arg Ser Tyr Lys Cys Gly Ala 
1               5                   10                  15      


Glu Asp Ser Phe Lys Glu Glu Arg Asn Ile Asp Pro Glu Thr Pro Ala 
            20                  25                  30          


Gly Cys Leu Ile Asn Ser Ser Ser Ala Ser Ser Pro Ala Ser His Leu 
        35                  40                  45              


Leu Cys Ala Pro Arg Gln Ser Ala Gln Ser His Val His Pro Arg Ser 
    50                  55                  60                  


Ala Leu Ser Pro Ala His His Gln Ser Val His Ser Pro Ala His Leu 
65                  70                  75                  80  


Ser Ser Ala Ser Arg Asn Ile Leu Leu 
                85                  


<210>  6699
<211>  905
<212>  DNA
<213>  Homosapiens

<400>  6699
ctgtagtaca catccttgat ggcaccaagt agcaaacgtg ctgtggagac tagatctcac     60

tctcaaatct gtcctgggat gcaagtgcct ctacgaatgt ggtgcagaag ctacaaatgt    120

ggtgcagaag acagcttcaa agaggaaagg aatataggtg ccaagagcct gcaatccttc    180

ccaaacagcc ctttgttctg tgctcaagtc aacccactgg gactttacta cagataatga    240

taagagaaat ggcttgtgag attgctcatg atcctgagac tccagcagga tgtcttatca    300

acagcagcag tgcaagcagc cctgccagcc acctcctgtg tgccccacgc caaagtgccc    360

agagccatgt ccacccccga agtgccctga gccctgccca tcaccaaagt gtccacagcc    420

ctgcccacct cagcagtgcc agcagaaata tcctcctgtg acaccttccc caccctgcca    480

gccaaagtgt ccacccaaga gcaagtaaca gcttcaggat tcatcaggag catgagagga    540

taaggataat tggctcacct cgttccacag ctccacttgc atcttctcac caaagccttc    600

catggatgca cagggagctt ctttctcctt aacctgtggc ctgcctgtga tgatctgtga    660

cagcaaaaga ttccctttct gaggctgcca tactgccact gtccaggtgg agctaagaaa    720

aggaagtcct cagctgtgcc agctcccaga gcttcggaag aaagagcagc agctctctcc    780

ctgggaacca tcagacaatt ctgttgatgt gttctgtgtc tgtctgtcac ctggtcatga    840

gcttctacca cctttgcaat tgtcatttat ctttcactcc ctgaataaag tatctatgca    900

tatat                                                                905


<210>  6700
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  6700

Met Trp Cys Arg Arg Gln Leu Gln Arg Gly Lys Glu Tyr Arg Cys Gln 
1               5                   10                  15      


Glu Pro Ala Ile Leu Pro Lys Gln Pro Phe Val Leu Cys Ser Ser Gln 
            20                  25                  30          


Pro Thr Gly Thr Leu Leu Gln Ile Met Ile Arg Glu Met Ala Cys Glu 
        35                  40                  45              


Ile Ala His Asp Pro Glu Thr Pro Ala Gly Cys Leu Ile Asn Ser Ser 
    50                  55                  60                  


Ser Ala Ser Ser Pro Ala Ser His Leu Leu Cys Ala Pro Arg Gln Ser 
65                  70                  75                  80  


Ala Gln Ser His Val His Pro Arg Ser Ala Leu Ser Pro Ala His His 
                85                  90                  95      


Gln Ser Val His Ser Pro Ala His Leu Ser Ser Ala Ser Arg Asn Ile 
            100                 105                 110         


Leu Leu 
        


<210>  6701
<211>  897
<212>  DNA
<213>  Homosapiens

<400>  6701
aggctgtagt acacatcctt gatggcacca agtagcaaac gtgctgtgga gactagatct     60

cactctcaaa tctgtcctgg gatgcaagtg cctctacgaa tgtggtgcag aagctacaaa    120

tgtggtgcag aagacagctt caaagaggaa aggaatatag gtaaaaatct gaggttttat    180

ctgagaaaaa ggtggcaaag aaaatttcag tcttgaacag ggtcagcaga tagcacaatg    240

tggtcagcct gcaaacccag agatcctgag actccagcag gatgtcttat caacagcagc    300

agtgcaagca gccctgccag ccacctcctg tgtgccccac gccaaagtgc ccagagccat    360

gtccaccccc gaagtgccct gagccctgcc catcaccaaa gtgtccacag ccctgcccac    420

ctcagcagtg ccagcagaaa tatcctcctg tgacaccttc cccaccctgc cagccaaagt    480

gtccacccaa gagcaagtaa cagcttcagg attcatcagg agcatgagag gataaggata    540

attggctcac ctcgttccac agctccactt gcatcttctc accaaagcct tccatggatg    600

cacagggagc ttctttctcc ttaacctgtg gcctgcctgt gatgatctgt gacagcaaaa    660

gattcccttt ctgaggctgc catactgcca ctgtccaggt ggagctaaga aaaggaagtc    720

ctcagctgtg ccagctccca gagcttcgga agaaagagca gcagctctct ccctgggaac    780

catcagacaa ttctgttgat gtgttctgtg tctgtctgtc acctggtcat gagcttctac    840

cacctttgca attgtcattt atctttcact ccctgaataa agtatctatg catatat       897


<210>  6702
<211>  71
<212>  PRT
<213>  Homosapiens

<400>  6702

Met Trp Ser Ala Cys Lys Pro Arg Asp Pro Glu Thr Pro Ala Gly Cys 
1               5                   10                  15      


Leu Ile Asn Ser Ser Ser Ala Ser Ser Pro Ala Ser His Leu Leu Cys 
            20                  25                  30          


Ala Pro Arg Gln Ser Ala Gln Ser His Val His Pro Arg Ser Ala Leu 
        35                  40                  45              


Ser Pro Ala His His Gln Ser Val His Ser Pro Ala His Leu Ser Ser 
    50                  55                  60                  


Ala Ser Arg Asn Ile Leu Leu 
65                  70      


<210>  6703
<211>  676
<212>  DNA
<213>  Homosapiens

<400>  6703
aaacccctgg tacctgagca ctgatctgcc ttggagaacc tgatcctgag actccagcag     60

gatgtcttat caacagcagc agtgcaagca gccctgccag ccacctcctg tgtgccccac    120

gccaaagtgc ccagagccat gtccaccccc gaagtgccct gagccctgcc caccaccaaa    180

gtgtccacag ccctgcccac ctcagcagtg ccagcagaaa tatcctcctg tgacaccttc    240

cccaccctgc cagtcaaagt atccaccgaa gagcaagtaa cagcttcaga attcatcagg    300

accaagaaag gataaggata tttggctcac ctcgttccac agctccacct tcatcttctc    360

atcaaagcct accatggata cacagggagc ttctttctcc ttagccagta atctgcccat    420

gatgatccct gacagcaaaa agtttctttt ctgaggctgc catactgcca ctgtccaggt    480

ggagactgag caaaggaagt cctgggctgt gccagctccc agagcttcgg aagaaagagc    540

agcagctctc tccctgggaa ccatcagaga attctgttga tgtgttctgt gtctgtctgt    600

cacctggtca cgagcttcta ccacctttgc aattgtcact tatctttcac tccctgaata    660

aagtatctat gcatat                                                    676


<210>  6704
<211>  72
<212>  PRT
<213>  Homosapiens

<400>  6704

Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Pro Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Tyr Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Ser Lys Tyr Pro Pro Lys Ser Lys 
65                  70          


<210>  6705
<211>  605
<212>  DNA
<213>  Homosapiens

<400>  6705
agtgaaagat aagtgacaat tgcaaaggtg gtagaagctc gtgaccaggg gacagacaga     60

cacagaaaac atcaacagaa ttctctaatg gttcccaggg agagagctgc tctttcttct    120

gaagctctgg gagctggcac agcccaggac ttcctttgct cagtctccac ctggacagtg    180

gcagtatggc agcctcaaaa agaaaacctt ttgctatcag agatcatcac aggccgatca    240

caggctaaga ggaaagaagc tccctgtgta tccctggatg gctttgatga gaagatgcag    300

gtggagctgt ggaacgaggt gagccaatta tccttatcct ttcatgctcc tgatgaatcc    360

tgaagctgtt acttgctctt gggtggacac tttggctggc agggtgggga aggtgtcaca    420

ggaggacatt tctgctggca ctgctgaggt gggcaggact gtggacactt tgatggtggg    480

cagggctcag ggcacttcgg gggtggacat ggctctgggc actttggcgc ggggcacaca    540

ggaggtggct ggcagggctg cttgcactgc tgctgttgat aagacatcct gctggagtct    600

cagaa                                                                605


<210>  6706
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  6706

Met Val Pro Arg Glu Arg Ala Ala Leu Ser Ser Glu Ala Leu Gly Ala 
1               5                   10                  15      


Gly Thr Ala Gln Asp Phe Leu Cys Ser Val Ser Thr Trp Thr Val Ala 
            20                  25                  30          


Val Trp Gln Pro Gln Lys Glu Asn Leu Leu Leu Ser Glu Ile Ile Thr 
        35                  40                  45              


Gly Arg Ser Gln Ala Lys Arg Lys Glu Ala Pro Cys Val Ser Leu Asp 
    50                  55                  60                  


Gly Phe Asp Glu Lys Met Gln Val Glu Leu Trp Asn Glu Val Ser Gln 
65                  70                  75                  80  


Leu Ser Leu Ser Phe His Ala Pro Asp Glu Ser 
                85                  90      


<210>  6707
<211>  681
<212>  DNA
<213>  Homosapiens

<400>  6707
cctaaactcc tggtacttga gcactgatct gctttggaga acctgattct gagactccag     60

caggatgtct tatcaacagc agcagtgcaa gcagccctgc cagccacctc ctgtgtgccc    120

cacgccaaag tgcccagagc catgtccacc cccgaagtgc cctgagccct gcccaccacc    180

aaagtgtcca cagccctgcc cacctcagca gtgccagcaa aaatgtcctc ctgtgacacc    240

ttccccaccc tgccagccaa agtgtccacc caagagcaag taacagcttc agaattcatc    300

aggagcatga aaggataagg ataattggct caccttgttc cacagcttca cctgcatctt    360

ctcatcaaag cctaccatgg atacacagtt agcttctttc ctcttagcca gtgatctgcc    420

catgatgatc cctgatagca aaaggtttcc tttctgaggc tgccatattg ccactgtcca    480

ggtggagact gagaaaggaa gtcctcagca gtgtcagttc ccagagcttt ggaagaagga    540

ccagcagctc tgtccctggg aaccatcaaa aaatgctgtt gatgttttct gtgtctgtct    600

gtcacctggg catgggcttc taacacctgt gcaattgtca cttttctttc actccctgaa    660

taaaatatct ttgcatacgt a                                              681


<210>  6708
<211>  72
<212>  PRT
<213>  Homosapiens

<400>  6708

Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Pro Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Cys Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210>  6709
<211>  692
<212>  DNA
<213>  Homosapiens

<400>  6709
gaaagtgtct gttcttgtct tttgttcact tttcaaaggg gctgtttatt tttcatattc     60

tgagactcca gcaggatgtc ttatcaacag cagcagtgca agcagccctg ccagccacct    120

cctgtgtgcc ccacgccaaa gtgcccagag ccatgtccac ccccgaagtg ccctgagccc    180

tgcccaccac caaagtgtcc acagccctgc ccacctcagc agtgccagca aaaatgtcct    240

cctgtgacac cttccccacc ctgccagcca aagtgtccac ccaagagcaa gtaacagctt    300

cagaattcat caggagcatg aaaggataag gataattggc tcaccttgtt ccacagcttc    360

acctgcatct tctcatcaaa gcctaccatg gatacacagt tagcttcttt cctcttagcc    420

agtgatctgc ccatgatgat ccctgatagc aaaaggtttc ctttctgagg ctgccatatt    480

gccactgtcc aggtggagac tgagaaagga agtcctcagc agtgtcagtt cccagagctt    540

tggaagaagg accagcagct ctgtccctgg gaaccatcaa aaaatgctgt tgatgttttc    600

tgtgtctgtc tgtcacctgg gcatgggctt ctaacacctg tgcaattgtc acttttcttt    660

cactccctga ataaaatatc tttgcatacg ta                                  692


<210>  6710
<211>  72
<212>  PRT
<213>  Homosapiens

<400>  6710

Met Ser Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro 
1               5                   10                  15      


Val Cys Pro Thr Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys 
            20                  25                  30          


Pro Glu Pro Cys Pro Pro Pro Lys Cys Pro Gln Pro Cys Pro Pro Gln 
        35                  40                  45              


Gln Cys Gln Gln Lys Cys Pro Pro Val Thr Pro Ser Pro Pro Cys Gln 
    50                  55                  60                  


Pro Lys Cys Pro Pro Lys Ser Lys 
65                  70          


<210>  6711
<211>  644
<212>  DNA
<213>  Homosapiens

<400>  6711
gttaatagga aggctttgat ttgaggaaga gattctgaga ctccagcagg atgtcttatc     60

aacagtagca atgtaagcag ccctgccagc cacctcctgt gtgccgcctg ccaaagcgtc    120

cagagccatg tccacccctg aagtgccctg agccctgccc accaccaaag tgtccacagc    180

cctgcccacc tcagcagtgc cagcagaaat atcctctggt gacaccttcc ccaccctgcc    240

agccaaagtg tccacccaag agcaagtaac agcttcggaa ttcatcagga ccacgaaagg    300

atagggataa ttggctcacc tcgttccaca gctccacctg catcttctca tcaaagccat    360

ccagggatac acagggagct tctttcccct tagcctgtga tctgcccatg atgatccccg    420

acagcaaaat gtttcctttc tgaggctgcc atgctgccac tgtccaggtg gagactgagc    480

aaaggaagtc ctcagctgta ccggcctttc agagcttctc tttgggtgcc atcaaagaat    540

tattttgatg tcttctgtct ctgtctgtca cctggcatga gcttctacta tctgtgcaat    600

tgtcactttt ctttcactcc ctgaataaag tagctatgcc tata                     644


<210>  6712
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  6712

Met Leu Pro Leu Ser Arg Trp Arg Leu Ser Lys Gly Ser Pro Gln Leu 
1               5                   10                  15      


Tyr Arg Pro Phe Arg Ala Ser Leu Trp Val Pro Ser Lys Asn Tyr Phe 
            20                  25                  30          


Asp Val Phe Cys Leu Cys Leu Ser Pro Gly Met Ser Phe Tyr Tyr Leu 
        35                  40                  45              


Cys Asn Cys His Phe Ser Phe Thr Pro 
    50                  55          


<210>  6713
<211>  680
<212>  DNA
<213>  Homosapiens

<400>  6713
agaggttctc agcctcatga ctcctaaact cctggtactt gagcaccgat ctgctttgga     60

gaacctgatt ctgagactcc agcaggatgt cttatcaaca gtagcaatgt aagcagccct    120

gccagccacc tcctgtgtgc cgcctgccaa agcgtccaga gccatgtcca cccctgaagt    180

gccctgagcc ctgcccacca ccaaagtgtc cacagccctg cccacctcag cagtgccagc    240

agaaatatcc tctggtgaca ccttccccac cctgccagcc aaagtgtcca cccaagagca    300

agtaacagct tcggaattca tcaggaccac gaaaggatag ggataattgg ctcacctcgt    360

tccacagctc cacctgcatc ttctcatcaa agccatccag ggatacacag ggagcttctt    420

tccccttagc ctgtgatctg cccatgatga tccccgacag caaaatgttt cctttctgag    480

gctgccatgc tgccactgtc caggtggaga ctgagcaaag gaagtcctca gctgtaccgg    540

cctttcagag cttctctttg ggtgccatca aagaattatt ttgatgtctt ctgtctctgt    600

ctgtcacctg gcatgagctt ctactatctg tgcaattgtc acttttcttt cactccctga    660

ataaagtagc tatgcctata                                                680


<210>  6714
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  6714

Met Thr Pro Lys Leu Leu Val Leu Glu His Arg Ser Ala Leu Glu Asn 
1               5                   10                  15      


Leu Ile Leu Arg Leu Gln Gln Asp Val Leu Ser Thr Val Ala Met 
            20                  25                  30      


<210>  6715
<211>  1164
<212>  DNA
<213>  Homosapiens

<400>  6715
agtctccagc atcctccacc tgtctaccac cgagcatggg cctatatttg aagccttaga     60

tctctccagc acagtaagca ccaggagtcc atgaagaaga tggctcctgc catggaatcc    120

cctactctac tgtgtgtagc cttactgttc ttcgctccag atggcgtgtt agcagtccct    180

cagaaaccta aggtctcctt gaaccctcca tggaatagaa tatttaaagg agagaatgtg    240

actcttacat gtaatgggaa caatttcttt gaagtcagtt ccaccaaatg gttccacaat    300

ggcagccttt cagaagagac aaattcaagt ttgaatattg tgaatgccaa atttgaagac    360

agtggagaat acaaatgtca gcaccaacaa gttaatgaga gtgaacctgt gtacctggaa    420

gtcttcagtg actggctgct ccttcaggcc tctgctgagg tggtgatgga gggccagccc    480

ctcttcctca ggtgccatgg ttggaggaac tgggatgtgt acaaggtgat ctattataag    540

gatggtgaag ctctcaagta ctggtatgag aaccacaaca tctccattac aaatgccaca    600

gttgaagaca gtggaaccta ctactgtacg ggcaaagtgt ggcagctgga ctatgagtct    660

gagcccctca acattactgt aataaaagct ccgcgtgaga agtactggct acaatttttt    720

atcccattgt tggtggtgat tctgtttgct gtggacacag gattatttat ctcaactcag    780

cagcaggtca catttctctt gaagattaag agaaccagga aaggcttcag acttctgaac    840

ccacatccta agccaaaccc caaaaacaac tgatataatt actcaagaaa tatttgcaac    900

attagttttt ttccagcatc agcaattgct actcaattgt caaacacagc ttgcaatata    960

catagaaacg tctgtgctca aggatttata gaaatgcttc attaaactga gtgaaactgg   1020

ttaagtggca tgtaatagta agtgctcaat taacattggt tgaataaatg agagaatgaa   1080

tagattcatt tattagcatt tgtaaaagag atgttcaatt tcaataaaat aaatataaaa   1140

ccatgtaaca gaatgcttct gagt                                          1164


<210>  6716
<211>  260
<212>  PRT
<213>  Homosapiens

<400>  6716

Met Lys Lys Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val 
1               5                   10                  15      


Ala Leu Leu Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys 
            20                  25                  30          


Pro Lys Val Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val Ser Ser 
    50                  55                  60                  


Thr Lys Trp Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser 
65                  70                  75                  80  


Leu Asn Ile Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys 
                85                  90                  95      


Gln His Gln Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe 
            100                 105                 110         


Ser Asp Trp Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly 
        115                 120                 125             


Gln Pro Leu Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr 
    130                 135                 140                 


Lys Val Ile Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu 
145                 150                 155                 160 


Asn His Asn Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr 
                165                 170                 175     


Tyr Tyr Cys Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro 
            180                 185                 190         


Leu Asn Ile Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln 
        195                 200                 205             


Phe Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys 
225                 230                 235                 240 


Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn 
                245                 250                 255     


Pro Lys Asn Asn 
            260 


<210>  6717
<211>  982
<212>  DNA
<213>  Homosapiens

<400>  6717
acagtaagca ccaggagtcc atgaagaaga tggctcctgc catggaatcc cctactctac     60

tgtgtgtagc cttactgttc ttcgctccag atggcgtgtt agcagtcagt tccaccaaat    120

ggttccacaa tggcagcctt tcagaagaga caaattcaag tttgaatatt gtgaatgcca    180

aatttgaaga cagtggagaa tacaaatgtc agcaccaaca agttaatgag agtgaacctg    240

tgtacctgga agtcttcagt gactggctgc tccttcaggc ctctgctgag gtggtgatgg    300

agggccagcc cctcttcctc aggtgccatg gttggaggaa ctgggatgtg tacaaggtga    360

tctattataa ggatggtgaa gctctcaagt actggtatga gaaccacaac atctccatta    420

caaatgccac agttgaagac agtggaacct actactgtac gggcaaagtg tggcagctgg    480

actatgagtc tgagcccctc aacattactg taataaaagc tccgcgtgag aagtactggc    540

tacaattttt tatcccattg ttggtggtga ttctgtttgc tgtggacaca ggattattta    600

tctcaactca gcagcaggtc acatttctct tgaagattaa gagaaccagg aaaggcttca    660

gacttctgaa cccacatcct aagccaaacc ccaaaaacaa ctgatataat tactcaagaa    720

atatttgcaa cattagtttt tttccagcat cagcaattgc tactcaattg tcaaacacag    780

cttgcaatat acatagaaac gtctgtgctc aaggatttat agaaatgctt cattaaactg    840

agtgaaactg gttaagtggc atgtaatagt aagtgctcaa ttaacattgg ttgaataaat    900

gagagaatga atagattcat ttattagcat ttgtaaaaga gatgttcaat ttcaataaaa    960

taaatataaa accatgtaac ag                                             982


<210>  6718
<211>  227
<212>  PRT
<213>  Homosapiens

<400>  6718

Met Lys Lys Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val 
1               5                   10                  15      


Ala Leu Leu Phe Phe Ala Pro Asp Gly Val Leu Ala Val Ser Ser Thr 
            20                  25                  30          


Lys Trp Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu 
        35                  40                  45              


Asn Ile Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln 
    50                  55                  60                  


His Gln Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe Ser 
65                  70                  75                  80  


Asp Trp Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly Gln 
                85                  90                  95      


Pro Leu Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr Lys 
            100                 105                 110         


Val Ile Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn 
        115                 120                 125             


His Asn Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr 
    130                 135                 140                 


Tyr Cys Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu 
145                 150                 155                 160 


Asn Ile Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln Phe 
                165                 170                 175     


Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu 
            180                 185                 190         


Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg 
        195                 200                 205             


Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro 
    210                 215                 220                 


Lys Asn Asn 
225         


<210>  6719
<211>  1058
<212>  DNA
<213>  Homosapiens

<400>  6719
cctgtgaaga aggtgccttg cttccccttt gccttccacc acaatgctaa gtttcttgag     60

gcctcccgag acatgctgaa ctgtgagtca gtcaactaag cctctttcct ttataaatta    120

cccagtttca ggcaattctt tatagcaatg tgaaaatgga ctaatataca actgaagtca    180

tttggtaaaa taagcttcaa gattcctctt ttcatctctc actgaagaaa tatacccctt    240

ttcataagaa aatctacaaa gagtatttat aagaaattgg tgcatggctg tgcttcaact    300

cctcagtgca tgatatgaaa gaaaatcaga tgaggttgca agaaataaat tttgtgttag    360

acatcagaga ccatttcttg acaggaaaag ttgtttgtga tgtgtgcagc atggtttctc    420

aagatctggc tgtataaaca atggacaggg ctgagaacca ggaagtgcag tgtctctggg    480

atctatgctt gatgcctcta actctgctta gcactgagta tgtaggatag tccccatgta    540

ttgacaactc atattaaact gtatatggaa gcacaaacat tgaagaatag ccaaacattc    600

ttgaagaaaa gaaacaaatg gagagaactt gtccttcaaa tatcatttac tataataaag    660

ctgtagtaat taagaaggca tggttttggc acagggataa gcactcaaac caatgagaga    720

aaatggaatt ctaaaatatg aaaattattc aaacggggct ggcattcctg attgatggaa    780

agcacagact agtcaattaa tgcaatagtt ggtcattcat atgaggaaaa aatgaaatta    840

ggttagctta taccatacaa aattcaatca caaatggatt aaaaacctat aaacaaacaa    900

aaaactctat taaatattta gaagacacta tgtgagaata tttttaaaac ttgagataaa    960

tgattcctta aggtacaaaa cagcaaaaaa tgacaacctt tattatataa aaattaattt   1020

gtgttttcca gaatcacaaa aaagaaaaaa agcaaggt                           1058


<210>  6720
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  6720

Met Lys Glu Asn Gln Met Arg Leu Gln Glu Ile Asn Phe Val Leu Asp 
1               5                   10                  15      


Ile Arg Asp His Phe Leu Thr Gly Lys Val Val Cys Asp Val Cys Ser 
            20                  25                  30          


Met Val Ser Gln Asp Leu Ala Val 
        35                  40  


<210>  6721
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  6721
atgcttttat gtttcagatt tgggaaccaa tccatgaaaa gagagaactt tactctcatc     60

actgactttg ttttccaagg tttctctagc ttccatgagc agcagatcac cctttttggc    120

gtgttccttg cactatacat cttaacctta gcaggcaata tcatcattgt gaccatcatc    180

cgaatggatc ttcatcttca cacacccatg tacttcttcc tgagcatgct gtccacttca    240

gagactgtat atacattggt cattctccca agaatgctct ccagcctcgt aggtatgagc    300

cagcccatat cattggcagg gtgtgccaca cagatgttct tttttgtaac ctttggcatc    360

actaactgct tcctgctcac agcaatggga tatgaccgct atgtggccat ctgcaacccc    420

ctgagataca tggttattat gaacaagagg ctgcgtatcc aacttgtcct gggggcctgc    480

agcattgggc tgattgtagc aataacgcaa gtgacatctg tattcaggtt acccttctgt    540

gctagaaagg tgccccactt cttctgtgac atccgccctg tgatgaagct ctcctgcatt    600

gacaccactg tcaatgaaat cctgactttg attatcagtg tgctggtgct tgttgtacct    660

atgggtctgg ttttcatttc ttatgttctc attatctcta caatcctcaa gattgcttca    720

gttgagggcc ggaagaaggc ttttgccacc tgtgcatccc acctcactgt ggtcattgtc    780

cactacagct gtgcctccat tgcctacctc aagcccaagt cagagaacac cagagaacat    840

gaccagctga tctcggtgac ctacactgtc atcactcccc tactgaaccc tgtggtatac    900

accctgagaa ataaagaggt caaagatgct ctgtgcaggg ctgttggtgg gaagttttcc    960

tga                                                                  963


<210>  6722
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  6722

Met Leu Leu Cys Phe Arg Phe Gly Asn Gln Ser Met Lys Arg Glu Asn 
1               5                   10                  15      


Phe Thr Leu Ile Thr Asp Phe Val Phe Gln Gly Phe Ser Ser Phe His 
            20                  25                  30          


Glu Gln Gln Ile Thr Leu Phe Gly Val Phe Leu Ala Leu Tyr Ile Leu 
        35                  40                  45              


Thr Leu Ala Gly Asn Ile Ile Ile Val Thr Ile Ile Arg Met Asp Leu 
    50                  55                  60                  


His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Met Leu Ser Thr Ser 
65                  70                  75                  80  


Glu Thr Val Tyr Thr Leu Val Ile Leu Pro Arg Met Leu Ser Ser Leu 
                85                  90                  95      


Val Gly Met Ser Gln Pro Ile Ser Leu Ala Gly Cys Ala Thr Gln Met 
            100                 105                 110         


Phe Phe Phe Val Thr Phe Gly Ile Thr Asn Cys Phe Leu Leu Thr Ala 
        115                 120                 125             


Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Met 
    130                 135                 140                 


Val Ile Met Asn Lys Arg Leu Arg Ile Gln Leu Val Leu Gly Ala Cys 
145                 150                 155                 160 


Ser Ile Gly Leu Ile Val Ala Ile Thr Gln Val Thr Ser Val Phe Arg 
                165                 170                 175     


Leu Pro Phe Cys Ala Arg Lys Val Pro His Phe Phe Cys Asp Ile Arg 
            180                 185                 190         


Pro Val Met Lys Leu Ser Cys Ile Asp Thr Thr Val Asn Glu Ile Leu 
        195                 200                 205             


Thr Leu Ile Ile Ser Val Leu Val Leu Val Val Pro Met Gly Leu Val 
    210                 215                 220                 


Phe Ile Ser Tyr Val Leu Ile Ile Ser Thr Ile Leu Lys Ile Ala Ser 
225                 230                 235                 240 


Val Glu Gly Arg Lys Lys Ala Phe Ala Thr Cys Ala Ser His Leu Thr 
                245                 250                 255     


Val Val Ile Val His Tyr Ser Cys Ala Ser Ile Ala Tyr Leu Lys Pro 
            260                 265                 270         


Lys Ser Glu Asn Thr Arg Glu His Asp Gln Leu Ile Ser Val Thr Tyr 
        275                 280                 285             


Thr Val Ile Thr Pro Leu Leu Asn Pro Val Val Tyr Thr Leu Arg Asn 
    290                 295                 300                 


Lys Glu Val Lys Asp Ala Leu Cys Arg Ala Val Gly Gly Lys Phe Ser 
305                 310                 315                 320 


<210>  6723
<211>  783
<212>  DNA
<213>  Homosapiens

<400>  6723
tgtggacttc aactctgaca agtctgaatc ccagtggaaa tgcaagttag cctcaaactg     60

agaacctcat actacattca gaatatgttt tcatgtttcc aaaatgtcac caacaatgag    120

atgacaggaa cctgaaccaa aaggatgaga gtagagatgg aaagtaaatg ttgttacaaa    180

ggctaaatca gaaatttgtc ccagatctag tatggatcat gaagaagaag atagaatgaa    240

agaacactct taccattctg agtgccgaaa gcaggaggtg gttcctaaaa atatgaagtt    300

tgggtatcct atacaatgag agaagaatgt ctatcttcat tatgttcaag tacccagata    360

aatgaacctg ctgttataag ggggagacat gacaagcttt acgtgttgaa aatacaaaga    420

gcctgaccct acaggaatct ttctttctgg cctttttcat cgtgagtaca tgcttttgat    480

tttgatcatg gttaaataga aaatatttaa attataattt ctatccacaa ggataaaatt    540

tctatccaca atttctaacc aacaagagtc cccgtgactc acctggcaca gaggttggga    600

aacttcaagt tgattcccag gcctaagtat ggaacagtct ttatcacttt ccaaaatgta    660

gcctgtccac attttcttgt gctgcataag cccatcatcc caatataata cagtagagaa    720

aaagaaactg atgctgaaat tctcatgggc tttgatgagc agaaacttgg taatataatt    780

ttg                                                                  783


<210>  6724
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  6724

Met Arg Glu Glu Cys Leu Ser Ser Leu Cys Ser Ser Thr Gln Ile Asn 
1               5                   10                  15      


Glu Pro Ala Val Ile Arg Gly Arg His Asp Lys Leu Tyr Val Leu Lys 
            20                  25                  30          


Ile Gln Arg Ala 
        35      


<210>  6725
<211>  4370
<212>  DNA
<213>  Homosapiens

<400>  6725
gggcatgact ctctctcttg agtaggcaca cactcccttt tctcgggtgt gtactttttg     60

ctttgtgata catctctgca ctttcagtat tttccaactc atccttaaat tccttctcac    120

aacagtgtca agagcctgga cgccagccag gattgaggtc ctacgggtgt ttggggacct    180

ccccaagccc acgagtatca atggcagtat caattgtctg tgacagtgat taaggagcaa    240

aacacttgga acccacaaga ctcccagaag gtgaagttaa gagctcccag actcataagg    300

ttattagaac agcaaactgg caccccaaag aactttacgg agacttgcaa cctatcaaca    360

agttggatga gggattaaaa gccttcaaca accaacaacc ccaagcatca aactgaagga    420

aacattctaa ccttcacaga cagactggag gctggatggg gacctggctg aagacatctg    480

gagaatgaaa gttaagtacc agcttgcatt tttgtgcccc tagattattt ttgcatttta    540

aaataagaag catcaaattg cgtgtctctg tgtaaaagtt ctagcaattt gttttaaggt    600

gaacttattt tggcttaggg actacaaaaa gagaaggtaa ttcctaggga aggaagaaga    660

gaaagaaatg aaaattagag aataagatta ttttgaatga cttcaggtag cgaggagtgt    720

gtgtttgtga gtgtgtattt gagagacttg gctcatgcct gtgggtcttc tcttctagta    780

tcagtgaggg gagggattac tgaagaagaa ggggggaaaa aaaaagaaag aaatctgagc    840

tttctgggag gaaattcaaa ggaaccaaga gaaattaact tcgttctgca aggactaaag    900

tacagcaaga ggagagaggt caagcgagaa gcgtgcggga agcacatgcc ctggggaggc    960

atagaagcca cactggcaga gcggccagca caggtagcca gcagaggcat tcttggggct   1020

atttgaaaaa gtttggtctg tgaacaaaac agtttccctg gtgactgcaa atccattgct   1080

agctgcctct ttctcgtctg cccatcactc tggtgtggta cccagaagtt gacttctggt   1140

tctgtagaaa gagctagggg aggtatgatg tgcttaaaga tcctaagaat aagcctggcg   1200

attttggctg ggtgggcact ctgttctgcc aactctgagc tgggctggac acgcaagaaa   1260

tccttggttg agagggaaca cctgaatcag gtgctgttgg aaggagaacg ttgttggctg   1320

ggggccaagg ttcgaagacc cagagcttct ccacagcatc acctctttgg agtctacccc   1380

agcagggctg ggaactacct aaggccctac cccgtggggg agcaagaaat ccatcataca   1440

ggacgcagca aaccagacac tgaaggaaat gctgtgagcc ttgttccccc agacctgact   1500

gaaaatccag caggactgag gggtgcagtt gaagagccgg ctgccccatg ggtaggggat   1560

agtcctattg ggcaatctga gctgctggga gatgatgacg cttatctcgg caatcaaaga   1620

tccaaggagt ctctaggtga ggccgggatt cagaaaggct cagccatggc tgccactact   1680

accaccgcca ttttcacaac cctgaacgaa cccaaaccag agacccaaag gaggggctgg   1740

gccaagtcca ggcagcgtcg ccaagtgtgg aagaggcggg cggaagatgg gcagggagac   1800

tccggtatct cttcacattt ccaaccttgg cccaagcatt cccttaaaca cagggtcaaa   1860

aagagtccac cggaggaaag caaccaaaat ggtggagagg gctcctaccg agaagcagag   1920

acctttaact cccaagtagg actgcccatc ttatacttct ctgggaggcg ggagcggctg   1980

ctgctgcgtc cagaagtgct ggctgagatt ccccgggagg cgttcacagt ggaagcctgg   2040

gttaaaccgg agggaggaca gaacaaccca gccatcatcg caggtgtgtt tgataactgc   2100

tcccacactg tcagtgacaa aggctgggcc ctggggatcc gctcagggaa ggacaaggga   2160

aagcgggatg ctcgcttctt cttctccctc tgcaccgacc gcgtgaagaa agccaccatc   2220

ttgattagcc acagtcgcta ccaaccaggc acatggaccc atgtggcagc cacttacgat   2280

ggacggcaca tggccctgta tgtggatggc actcaggtgg ctagcagtct agaccagtct   2340

ggtcccctga acagcccctt catggcatct tgccgctctt tgctcctggg gggagacagc   2400

tctgaggatg ggcactattt ccgtggacac ctgggcacac tggttttctg gtcgaccgcc   2460

ctgccacaaa gccattttca gcacagttct cagcattcaa gtggggagga ggaagcgact   2520

gacttggtcc tgacagcgag ctttgagcct gtgaacacag agtgggttcc ctttagagat   2580

gagaagtacc cacgacttga ggttctccag ggctttgagc cagagcctga gattctgtcg   2640

cctttgcagc ccccactctg tgggcaaaca gtctgtgaca atgtggaatt gatctcccag   2700

tacaatggat actggcccct tcggggagag aaggtgatac gctaccaggt ggtgaacatc   2760

tgtgatgatg agggcctaaa ccccattgtg agtgaggagc agattcgtct gcagcacgag   2820

gcactgaatg aggccttcag ccgctacaac atcagctggc agctgagcgt ccaccaggtc   2880

cacaattcca ccctgcgaca ccgggttgtg cttgtgaact gtgagcccag caagattggc   2940

aatgaccatt gtgaccccga gtgtgagcac ccactcacag gctatgatgg gggtgactgc   3000

cgcctgcagg gccgctgcta ctcctggaac cgcagggatg ggctctgtca cgtggagtgt   3060

aacaacatgc tgaacgactt tgacgacgga gactgctgcg acccccaggt ggctgatgtg   3120

cgcaagacct gctttgaccc tgactcaccc aagagggcat acatgagtgt gaaggagctg   3180

aaggaggccc tgcagctgaa cagtactcac ttcctcaaca tctactttgc cagctcagtg   3240

cgggaagacc ttgcaggtgc tgccacctgg ccttgggaca aggacgctgt cactcacctg   3300

ggtggcattg tcctcagccc agcatattat gggatgcctg gccacaccga caccatgatc   3360

catgaagtgg gacatgttct gggactctac catgtcttta aaggagtcag tgaaagagaa   3420

tcctgcaatg acccctgcaa ggagacagtg ccatccatgg aaacgggaga cctctgtgcc   3480

gacaccgccc ccactcccaa gagtgagctg tgccgggaac cagagcccac tagtgacacc   3540

tgtggcttca ctcgcttccc aggggctccg ttcaccaact acatgagcta cacgggtatc   3600

accactgtct tgttttgttt tctgttaaga atacatgggg gcctttgaga gctgggaggg   3660

tggaggtgtg ggagctgatg ggagaatgat taagtggtca tttgtgtcgg agagttgaag   3720

tgtatttatt ataaggtatt attatttttt catgtctttg aagaacttga agaaatactg   3780

acatattaag gtactttgtt cactgaattc tcctctacta gatattttaa aatatacttc   3840

tatcctcgat agtaaaaaag gcacagagcc aaaagccctc ttgtgatccc cttgacttct   3900

agaatgtggt tattcttatt tttgcccgca ttcttagaca tttactctga agaagagtcc   3960

aatggaaata aaggaaaaga gtttatgggt caaggtggcc cattgtactg tttttgaagt   4020

tggtcaacaa ggtggcttgg ttaatttagg ctcagcatgt tttactgtat gttactaaaa   4080

aaaaaaaaaa aaaaaatcag attctctttt tccagcacta gtcaagcaca aattcttagc   4140

tgcctaccac cctttcccca ccaaaaggtg acatctaatt ttaaaaaaat ggcatcttcc   4200

tggccctcgg aaaaacttgt catctggtct ttcttgcctt aattcagctt ctgtattatt   4260

cttcgctgtc tctcacgcct tccttgtttc ttgtgaaaag taatagtgac tggtttccta   4320

taatggactc aaagttatcc ctaaaattaa agacttattt gatgacctag              4370


<210>  6726
<211>  827
<212>  PRT
<213>  Homosapiens

<400>  6726

Met Met Cys Leu Lys Ile Leu Arg Ile Ser Leu Ala Ile Leu Ala Gly 
1               5                   10                  15      


Trp Ala Leu Cys Ser Ala Asn Ser Glu Leu Gly Trp Thr Arg Lys Lys 
            20                  25                  30          


Ser Leu Val Glu Arg Glu His Leu Asn Gln Val Leu Leu Glu Gly Glu 
        35                  40                  45              


Arg Cys Trp Leu Gly Ala Lys Val Arg Arg Pro Arg Ala Ser Pro Gln 
    50                  55                  60                  


His His Leu Phe Gly Val Tyr Pro Ser Arg Ala Gly Asn Tyr Leu Arg 
65                  70                  75                  80  


Pro Tyr Pro Val Gly Glu Gln Glu Ile His His Thr Gly Arg Ser Lys 
                85                  90                  95      


Pro Asp Thr Glu Gly Asn Ala Val Ser Leu Val Pro Pro Asp Leu Thr 
            100                 105                 110         


Glu Asn Pro Ala Gly Leu Arg Gly Ala Val Glu Glu Pro Ala Ala Pro 
        115                 120                 125             


Trp Val Gly Asp Ser Pro Ile Gly Gln Ser Glu Leu Leu Gly Asp Asp 
    130                 135                 140                 


Asp Ala Tyr Leu Gly Asn Gln Arg Ser Lys Glu Ser Leu Gly Glu Ala 
145                 150                 155                 160 


Gly Ile Gln Lys Gly Ser Ala Met Ala Ala Thr Thr Thr Thr Ala Ile 
                165                 170                 175     


Phe Thr Thr Leu Asn Glu Pro Lys Pro Glu Thr Gln Arg Arg Gly Trp 
            180                 185                 190         


Ala Lys Ser Arg Gln Arg Arg Gln Val Trp Lys Arg Arg Ala Glu Asp 
        195                 200                 205             


Gly Gln Gly Asp Ser Gly Ile Ser Ser His Phe Gln Pro Trp Pro Lys 
    210                 215                 220                 


His Ser Leu Lys His Arg Val Lys Lys Ser Pro Pro Glu Glu Ser Asn 
225                 230                 235                 240 


Gln Asn Gly Gly Glu Gly Ser Tyr Arg Glu Ala Glu Thr Phe Asn Ser 
                245                 250                 255     


Gln Val Gly Leu Pro Ile Leu Tyr Phe Ser Gly Arg Arg Glu Arg Leu 
            260                 265                 270         


Leu Leu Arg Pro Glu Val Leu Ala Glu Ile Pro Arg Glu Ala Phe Thr 
        275                 280                 285             


Val Glu Ala Trp Val Lys Pro Glu Gly Gly Gln Asn Asn Pro Ala Ile 
    290                 295                 300                 


Ile Ala Gly Val Phe Asp Asn Cys Ser His Thr Val Ser Asp Lys Gly 
305                 310                 315                 320 


Trp Ala Leu Gly Ile Arg Ser Gly Lys Asp Lys Gly Lys Arg Asp Ala 
                325                 330                 335     


Arg Phe Phe Phe Ser Leu Cys Thr Asp Arg Val Lys Lys Ala Thr Ile 
            340                 345                 350         


Leu Ile Ser His Ser Arg Tyr Gln Pro Gly Thr Trp Thr His Val Ala 
        355                 360                 365             


Ala Thr Tyr Asp Gly Arg His Met Ala Leu Tyr Val Asp Gly Thr Gln 
    370                 375                 380                 


Val Ala Ser Ser Leu Asp Gln Ser Gly Pro Leu Asn Ser Pro Phe Met 
385                 390                 395                 400 


Ala Ser Cys Arg Ser Leu Leu Leu Gly Gly Asp Ser Ser Glu Asp Gly 
                405                 410                 415     


His Tyr Phe Arg Gly His Leu Gly Thr Leu Val Phe Trp Ser Thr Ala 
            420                 425                 430         


Leu Pro Gln Ser His Phe Gln His Ser Ser Gln His Ser Ser Gly Glu 
        435                 440                 445             


Glu Glu Ala Thr Asp Leu Val Leu Thr Ala Ser Phe Glu Pro Val Asn 
    450                 455                 460                 


Thr Glu Trp Val Pro Phe Arg Asp Glu Lys Tyr Pro Arg Leu Glu Val 
465                 470                 475                 480 


Leu Gln Gly Phe Glu Pro Glu Pro Glu Ile Leu Ser Pro Leu Gln Pro 
                485                 490                 495     


Pro Leu Cys Gly Gln Thr Val Cys Asp Asn Val Glu Leu Ile Ser Gln 
            500                 505                 510         


Tyr Asn Gly Tyr Trp Pro Leu Arg Gly Glu Lys Val Ile Arg Tyr Gln 
        515                 520                 525             


Val Val Asn Ile Cys Asp Asp Glu Gly Leu Asn Pro Ile Val Ser Glu 
    530                 535                 540                 


Glu Gln Ile Arg Leu Gln His Glu Ala Leu Asn Glu Ala Phe Ser Arg 
545                 550                 555                 560 


Tyr Asn Ile Ser Trp Gln Leu Ser Val His Gln Val His Asn Ser Thr 
                565                 570                 575     


Leu Arg His Arg Val Val Leu Val Asn Cys Glu Pro Ser Lys Ile Gly 
            580                 585                 590         


Asn Asp His Cys Asp Pro Glu Cys Glu His Pro Leu Thr Gly Tyr Asp 
        595                 600                 605             


Gly Gly Asp Cys Arg Leu Gln Gly Arg Cys Tyr Ser Trp Asn Arg Arg 
    610                 615                 620                 


Asp Gly Leu Cys His Val Glu Cys Asn Asn Met Leu Asn Asp Phe Asp 
625                 630                 635                 640 


Asp Gly Asp Cys Cys Asp Pro Gln Val Ala Asp Val Arg Lys Thr Cys 
                645                 650                 655     


Phe Asp Pro Asp Ser Pro Lys Arg Ala Tyr Met Ser Val Lys Glu Leu 
            660                 665                 670         


Lys Glu Ala Leu Gln Leu Asn Ser Thr His Phe Leu Asn Ile Tyr Phe 
        675                 680                 685             


Ala Ser Ser Val Arg Glu Asp Leu Ala Gly Ala Ala Thr Trp Pro Trp 
    690                 695                 700                 


Asp Lys Asp Ala Val Thr His Leu Gly Gly Ile Val Leu Ser Pro Ala 
705                 710                 715                 720 


Tyr Tyr Gly Met Pro Gly His Thr Asp Thr Met Ile His Glu Val Gly 
                725                 730                 735     


His Val Leu Gly Leu Tyr His Val Phe Lys Gly Val Ser Glu Arg Glu 
            740                 745                 750         


Ser Cys Asn Asp Pro Cys Lys Glu Thr Val Pro Ser Met Glu Thr Gly 
        755                 760                 765             


Asp Leu Cys Ala Asp Thr Ala Pro Thr Pro Lys Ser Glu Leu Cys Arg 
    770                 775                 780                 


Glu Pro Glu Pro Thr Ser Asp Thr Cys Gly Phe Thr Arg Phe Pro Gly 
785                 790                 795                 800 


Ala Pro Phe Thr Asn Tyr Met Ser Tyr Thr Gly Ile Thr Thr Val Leu 
                805                 810                 815     


Phe Cys Phe Leu Leu Arg Ile His Gly Gly Leu 
            820                 825         


<210>  6727
<211>  6918
<212>  DNA
<213>  Homosapiens

<400>  6727
gggcatgact ctctctcttg agtaggcaca cactcccttt tctcgggtgt gtactttttg     60

ctttgtgata catctctgca ctttcagtat tttccaactc atccttaaat tccttctcac    120

aacagtgtca agagcctgga cgccagccag gattgaggtc ctacgggtgt ttggggacct    180

ccccaagccc acgagtatca atggcagtat caattgtctg tgacagtgat taaggagcaa    240

aacacttgga acccacaaga ctcccagaag gtgaagttaa gagctcccag actcataagg    300

ttattagaac agcaaactgg caccccaaag aactttacgg agacttgcaa cctatcaaca    360

agttggatga gggattaaaa gccttcaaca accaacaacc ccaagcatca aactgaagga    420

aacattctaa ccttcacaga cagactggag gctggatggg gacctggctg aagacatctg    480

gagaatgaaa gttaagtacc agcttgcatt tttgtgcccc tagattattt ttgcatttta    540

aaataagaag catcaaattg cgtgtctctg tgtaaaagtt ctagcaattt gttttaaggt    600

gaacttattt tggcttaggg actacaaaaa gagaaggtaa ttcctaggga aggaagaaga    660

gaaagaaatg aaaattagag aataagatta ttttgaatga cttcaggtag cgaggagtgt    720

gtgtttgtga gtgtgtattt gagagacttg gctcatgcct gtgggtcttc tcttctagta    780

tcagtgaggg gagggattac tgaagaagaa ggggggaaaa aaaaagaaag aaatctgagc    840

tttctgggag gaaattcaaa ggaaccaaga gaaattaact tcgttctgca aggactaaag    900

tacagcaaga ggagagaggt caagcgagaa gcgtgcggga agcacatgcc ctggggaggc    960

atagaagcca cactggcaga gcggccagca caggtagcca gcagaggcat tcttggggct   1020

atttgaaaaa gtttggtctg tgaacaaaac agtttccctg gtgactgcaa atccattgct   1080

agctgcctct ttctcgtctg cccatcactc tggtgtggta cccagaagtt gacttctggt   1140

tctgtagaaa gagctagggg aggtatgatg tgcttaaaga tcctaagaat aagcctggcg   1200

attttggctg ggtgggcact ctgttctgcc aactctgagc tgggctggac acgcaagaaa   1260

tccttggttg agagggaaca cctgaatcag gtgctgttgg aaggagaacg ttgttggctg   1320

ggggccaagg ttcgaagacc cagagcttct ccacagcatc acctctttgg agtctacccc   1380

agcagggctg ggaactacct aaggccctac cccgtggggg agcaagaaat ccatcataca   1440

ggacgcagca aaccagacac tgaaggaaat gctgtgagcc ttgttccccc agacctgact   1500

gaaaatccag caggactgag gggtgcagtt gaagagccgg ctgccccatg ggtaggggat   1560

agtcctattg ggcaatctga gctgctggga gatgatgacg cttatctcgg caatcaaaga   1620

tccaaggagt ctctaggtga ggccgggatt cagaaaggct cagccatggc tgccactact   1680

accaccgcca ttttcacaac cctgaacgaa cccaaaccag agacccaaag gaggggctgg   1740

gccaagtcca ggcagcgtcg ccaagtgtgg aagaggcggg cggaagatgg gcagggagac   1800

tccggtatct cttcacattt ccaaccttgg cccaagcatt cccttaaaca cagggtcaaa   1860

aagagtccac cggaggaaag caaccaaaat ggtggagagg gctcctaccg agaagcagag   1920

acctttaact cccaagtagg actgcccatc ttatacttct ctgggaggcg ggagcggctg   1980

ctgctgcgtc cagaagtgct ggctgagatt ccccgggagg cgttcacagt ggaagcctgg   2040

gttaaaccgg agggaggaca gaacaaccca gccatcatcg caggtgtgtt tgataactgc   2100

tcccacactg tcagtgacaa aggctgggcc ctggggatcc gctcagggaa ggacaaggga   2160

aagcgggatg ctcgcttctt cttctccctc tgcaccgacc gcgtgaagaa agccaccatc   2220

ttgattagcc acagtcgcta ccaaccaggc acatggaccc atgtggcagc cacttacgat   2280

ggacggcaca tggccctgta tgtggatggc actcaggtgg ctagcagtct agaccagtct   2340

ggtcccctga acagcccctt catggcatct tgccgctctt tgctcctggg gggagacagc   2400

tctgaggatg ggcactattt ccgtggacac ctgggcacac tggttttctg gtcgaccgcc   2460

ctgccacaaa gccattttca gcacagttct cagcattcaa gtggggagga ggaagcgact   2520

gacttggtcc tgacagcgag ctttgagcct gtgaacacag agtgggttcc ctttagagat   2580

gagaagtacc cacgacttga ggttctccag ggctttgagc cagagcctga gattctgtcg   2640

cctttgcagc ccccactctg tgggcaaaca gtctgtgaca atgtggaatt gatctcccag   2700

tacaatggat actggcccct tcggggagag aaggtgatac gctaccaggt ggtgaacatc   2760

tgtgatgatg agggcctaaa ccccattgtg agtgaggagc agattcgtct gcagcacgag   2820

gcactgaatg aggccttcag ccgctacaac atcagctggc agctgagcgt ccaccaggtc   2880

cacaattcca ccctgcgaca ccgggttgtg cttgtgaact gtgagcccag caagattggc   2940

aatgaccatt gtgaccccga gtgtgagcac ccactcacag gctatgatgg gggtgactgc   3000

cgcctgcagg gccgctgcta ctcctggaac cgcagggatg ggctctgtca cgtggagtgt   3060

aacaacatgc tgaacgactt tgacgacgga gactgctgcg acccccaggt ggctgatgtg   3120

cgcaagacct gctttgaccc tgactcaccc aagagggcat acatgagtgt gaaggagctg   3180

aaggaggccc tgcagctgaa cagtactcac ttcctcaaca tctactttgc cagctcagtg   3240

cgggaagacc ttgcaggtgc tgccacctgg ccttgggaca aggacgctgt cactcacctg   3300

ggtggcattg tcctcagccc agcatattat gggatgcctg gccacaccga caccatgatc   3360

catgaagtgg gacatgttct gggactctac catgtcttta aaggagtcag tgaaagagaa   3420

tcctgcaatg acccctgcaa ggagacagtg ccatccatgg aaacgggaga cctctgtgcc   3480

gacaccgccc ccactcccaa gagtgagctg tgccgggaac cagagcccac tagtgacacc   3540

tgtggcttca ctcgcttccc aggggctccg ttcaccaact acatgagcta cacggatgat   3600

aactgcactg acaacttcac tcctaaccaa gtggcccgaa tgcattgcta tttggaccta   3660

gtctatcagc agtggactga aagcagaaag cccaccccca tccccattcc acctatggtc   3720

atcggacaga ccaacaagtc cctcactatc cactggctgc ctcctattag tggagttgta   3780

tatgacaggg cctcaggcag cttgtgtggc gcttgcactg aagatgggac ctttcgtcag   3840

tatgtgcaca cagcttcctc ccggcgggtg tgtgactcct caggttattg gaccccagag   3900

gaggctgtgg ggcctcctga tgtggatcag ccctgcgagc caagcttaca ggcctggagc   3960

cctgaggtcc acctgtacca catgaacatg acggtcccct gccccacaga aggctgtagc   4020

ttggagctgc tcttccaaca cccggtccaa gccgacaccc tcaccctgtg ggtcacttcc   4080

ttcttcatgg agtcctcgca ggtcctcttt gacacagaga tcttgctgga aaacaaggag   4140

tcagtgcacc tgggcccctt agacactttc tgtgacatcc cactcaccat caaactgcac   4200

gtggatggga aggtgtcggg ggtgaaagtc tacacctttg atgagaggat agagattgat   4260

gcagcactcc tgacttctca gccccacagt cccttgtgct ctggctgcag gcctgtgagg   4320

taccaggttc tccgcgatcc cccatttgcc agtggtttgc ccgtggtggt gacacattct   4380

cacaggaagt tcacggacgt ggaggtcaca cctggacaga tgtatcagta ccaagttcta   4440

gctgaagctg gaggagaact gggagaagct tcgcctcctc tgaaccacat tcatggagct   4500

ccttattgtg gagatgggaa ggtgtcagag agactgggag aagagtgtga tgatggagac   4560

cttgtgagcg gagatggctg ctccaaggtg tgtgagctgg aggaaggttt caactgtgta   4620

ggagagccaa gcctttgcta catgtatgag ggagatggca tatgtgaacc ttttgagaga   4680

aaaaccagca ttgtagactg tggcatctac actcccaaag gatacttgga tcaatgggct   4740

acccgggctt actcctctca tgaagacaag aagaagtgtc ctgtttcctt ggtaactgga   4800

gaacctcatt ccctaatttg cacatcatac catccagatt tacccaacca ccgtccccta   4860

actggctggt ttccctgtgt tgccagtgaa aatgaaactc aggatgacag gagtgaacag   4920

ccagaaggta gcctgaagaa agaggatgag gtttggctca aagtgtgttt caatagacca   4980

ggagaggcca gagcaatttt tatttttttg acaactgatg gcctagttcc cggagagcat   5040

cagcagccga cagtgactct ctacctgacc gatgtccgtg gaagcaacca ctctcttgga   5100

acctatggac tgtcatgcca gcataatcca ctgattatca atgtgaccca tcaccagaat   5160

gtccttttcc accataccac ctcagtgctg ctgaatttct catccccacg ggtcggcatc   5220

tcagctgtgg ctctaaggac atcctcccgc attggtcttt cggctcccag taactgcatc   5280

tcagaggacg aggggcagaa tcatcaggga cagagctgta tccatcggcc ctgtgggaag   5340

caggacagct gtccgtcatt gctgcttgat catgctgatg tggtgaactg tacctctata   5400

ggcccaggtc tcatgaagtg tgctatcact tgtcaaaggg gatttgccct tcaggccagc   5460

agtgggcagt acatcaggcc catgcagaag gaaattctgc tcacatgttc ttctgggcac   5520

tgggaccaga atgtgagctg ccttcccgtg gactgcggtg ttcccgaccc gtctttggtg   5580

aactatgcaa acttctcctg ctcagaggga accaaatttc tgaaacgctg ctcaatctct   5640

tgtgtcccac cagccaagct gcaaggactg agcccatggc tgacatgtct tgaagatggt   5700

ctctggtctc tccctgaagt ctactgcaag ttggagtgtg atgctccccc tattattctg   5760

aatgccaact tgctcctgcc tcactgcctc caggacaacc acgacgtggg caccatctgc   5820

aaatatgaat gcaaaccagg gtactatgtg gcagaaagtg cagagggtaa agtcaggaac   5880

aagctcctga agatacaatg cctggaaggt ggaatctggg agcaaggcag ctgcattcct   5940

gtggtgtgtg agccaccccc tcctgtgttt gaaggcatgt atgaatgtac caatggcttc   6000

agcctggaca gccagtgtgt gctcaactgt aaccaggaac gtgaaaagct tcccatcctc   6060

tgcactaaag agggcctgtg gacccaggag tttaagttgt gtgagaatct gcaaggagaa   6120

tgcccaccac ccccctcaga gctgaattct gtggagtaca aatgtgaaca aggatatggg   6180

attggtgcag tgtgttcccc attgtgtgta atccccccca gtgaccccgt gatgctacct   6240

gagaatatca ctgctgacac tctggagcac tggatggaac ctgtcaaagt ccagagcatt   6300

gtgtgcactg gccggcgtca atggcaccca gaccccgtct tagtccactg catccagtca   6360

tgtgagccct tccaagcaga tggttggtgt gacactatca acaaccgagc ctactgccac   6420

tatgacgggg gagactgctg ctcttccaca ctctcctcca agaaggtcat tccatttgct   6480

gctgactgtg acctggatga gtgcacctgc cgggacccca aggcagaaga aaatcagtaa   6540

ctgtgggaac aagcccctcc ctccactgcc tcagaggcag taagaaagag aggccgaccc   6600

aggaggaaac aaagggtgaa tgaagaagaa caatcatgaa atggaagaag gaggaagagc   6660

atgaaggatc ttataagaaa tgcaagagga tattgatagg tgtgaactag ttcatcaagt   6720

agcccaagta ggagagaatc ataggcaaaa gtttctttaa agtggcagtt gattaacatg   6780

gaaggggaaa tatgatagat atataaggac cctcctccct cacttatatt ctattaaatc   6840

ctatcctcaa ctcttgccct gctctccgct ccaccccctg ccaactactc agtcccaccc   6900

aacttgtaaa ccaatacc                                                 6918


<210>  6728
<211>  1791
<212>  PRT
<213>  Homosapiens

<400>  6728

Met Met Cys Leu Lys Ile Leu Arg Ile Ser Leu Ala Ile Leu Ala Gly 
1               5                   10                  15      


Trp Ala Leu Cys Ser Ala Asn Ser Glu Leu Gly Trp Thr Arg Lys Lys 
            20                  25                  30          


Ser Leu Val Glu Arg Glu His Leu Asn Gln Val Leu Leu Glu Gly Glu 
        35                  40                  45              


Arg Cys Trp Leu Gly Ala Lys Val Arg Arg Pro Arg Ala Ser Pro Gln 
    50                  55                  60                  


His His Leu Phe Gly Val Tyr Pro Ser Arg Ala Gly Asn Tyr Leu Arg 
65                  70                  75                  80  


Pro Tyr Pro Val Gly Glu Gln Glu Ile His His Thr Gly Arg Ser Lys 
                85                  90                  95      


Pro Asp Thr Glu Gly Asn Ala Val Ser Leu Val Pro Pro Asp Leu Thr 
            100                 105                 110         


Glu Asn Pro Ala Gly Leu Arg Gly Ala Val Glu Glu Pro Ala Ala Pro 
        115                 120                 125             


Trp Val Gly Asp Ser Pro Ile Gly Gln Ser Glu Leu Leu Gly Asp Asp 
    130                 135                 140                 


Asp Ala Tyr Leu Gly Asn Gln Arg Ser Lys Glu Ser Leu Gly Glu Ala 
145                 150                 155                 160 


Gly Ile Gln Lys Gly Ser Ala Met Ala Ala Thr Thr Thr Thr Ala Ile 
                165                 170                 175     


Phe Thr Thr Leu Asn Glu Pro Lys Pro Glu Thr Gln Arg Arg Gly Trp 
            180                 185                 190         


Ala Lys Ser Arg Gln Arg Arg Gln Val Trp Lys Arg Arg Ala Glu Asp 
        195                 200                 205             


Gly Gln Gly Asp Ser Gly Ile Ser Ser His Phe Gln Pro Trp Pro Lys 
    210                 215                 220                 


His Ser Leu Lys His Arg Val Lys Lys Ser Pro Pro Glu Glu Ser Asn 
225                 230                 235                 240 


Gln Asn Gly Gly Glu Gly Ser Tyr Arg Glu Ala Glu Thr Phe Asn Ser 
                245                 250                 255     


Gln Val Gly Leu Pro Ile Leu Tyr Phe Ser Gly Arg Arg Glu Arg Leu 
            260                 265                 270         


Leu Leu Arg Pro Glu Val Leu Ala Glu Ile Pro Arg Glu Ala Phe Thr 
        275                 280                 285             


Val Glu Ala Trp Val Lys Pro Glu Gly Gly Gln Asn Asn Pro Ala Ile 
    290                 295                 300                 


Ile Ala Gly Val Phe Asp Asn Cys Ser His Thr Val Ser Asp Lys Gly 
305                 310                 315                 320 


Trp Ala Leu Gly Ile Arg Ser Gly Lys Asp Lys Gly Lys Arg Asp Ala 
                325                 330                 335     


Arg Phe Phe Phe Ser Leu Cys Thr Asp Arg Val Lys Lys Ala Thr Ile 
            340                 345                 350         


Leu Ile Ser His Ser Arg Tyr Gln Pro Gly Thr Trp Thr His Val Ala 
        355                 360                 365             


Ala Thr Tyr Asp Gly Arg His Met Ala Leu Tyr Val Asp Gly Thr Gln 
    370                 375                 380                 


Val Ala Ser Ser Leu Asp Gln Ser Gly Pro Leu Asn Ser Pro Phe Met 
385                 390                 395                 400 


Ala Ser Cys Arg Ser Leu Leu Leu Gly Gly Asp Ser Ser Glu Asp Gly 
                405                 410                 415     


His Tyr Phe Arg Gly His Leu Gly Thr Leu Val Phe Trp Ser Thr Ala 
            420                 425                 430         


Leu Pro Gln Ser His Phe Gln His Ser Ser Gln His Ser Ser Gly Glu 
        435                 440                 445             


Glu Glu Ala Thr Asp Leu Val Leu Thr Ala Ser Phe Glu Pro Val Asn 
    450                 455                 460                 


Thr Glu Trp Val Pro Phe Arg Asp Glu Lys Tyr Pro Arg Leu Glu Val 
465                 470                 475                 480 


Leu Gln Gly Phe Glu Pro Glu Pro Glu Ile Leu Ser Pro Leu Gln Pro 
                485                 490                 495     


Pro Leu Cys Gly Gln Thr Val Cys Asp Asn Val Glu Leu Ile Ser Gln 
            500                 505                 510         


Tyr Asn Gly Tyr Trp Pro Leu Arg Gly Glu Lys Val Ile Arg Tyr Gln 
        515                 520                 525             


Val Val Asn Ile Cys Asp Asp Glu Gly Leu Asn Pro Ile Val Ser Glu 
    530                 535                 540                 


Glu Gln Ile Arg Leu Gln His Glu Ala Leu Asn Glu Ala Phe Ser Arg 
545                 550                 555                 560 


Tyr Asn Ile Ser Trp Gln Leu Ser Val His Gln Val His Asn Ser Thr 
                565                 570                 575     


Leu Arg His Arg Val Val Leu Val Asn Cys Glu Pro Ser Lys Ile Gly 
            580                 585                 590         


Asn Asp His Cys Asp Pro Glu Cys Glu His Pro Leu Thr Gly Tyr Asp 
        595                 600                 605             


Gly Gly Asp Cys Arg Leu Gln Gly Arg Cys Tyr Ser Trp Asn Arg Arg 
    610                 615                 620                 


Asp Gly Leu Cys His Val Glu Cys Asn Asn Met Leu Asn Asp Phe Asp 
625                 630                 635                 640 


Asp Gly Asp Cys Cys Asp Pro Gln Val Ala Asp Val Arg Lys Thr Cys 
                645                 650                 655     


Phe Asp Pro Asp Ser Pro Lys Arg Ala Tyr Met Ser Val Lys Glu Leu 
            660                 665                 670         


Lys Glu Ala Leu Gln Leu Asn Ser Thr His Phe Leu Asn Ile Tyr Phe 
        675                 680                 685             


Ala Ser Ser Val Arg Glu Asp Leu Ala Gly Ala Ala Thr Trp Pro Trp 
    690                 695                 700                 


Asp Lys Asp Ala Val Thr His Leu Gly Gly Ile Val Leu Ser Pro Ala 
705                 710                 715                 720 


Tyr Tyr Gly Met Pro Gly His Thr Asp Thr Met Ile His Glu Val Gly 
                725                 730                 735     


His Val Leu Gly Leu Tyr His Val Phe Lys Gly Val Ser Glu Arg Glu 
            740                 745                 750         


Ser Cys Asn Asp Pro Cys Lys Glu Thr Val Pro Ser Met Glu Thr Gly 
        755                 760                 765             


Asp Leu Cys Ala Asp Thr Ala Pro Thr Pro Lys Ser Glu Leu Cys Arg 
    770                 775                 780                 


Glu Pro Glu Pro Thr Ser Asp Thr Cys Gly Phe Thr Arg Phe Pro Gly 
785                 790                 795                 800 


Ala Pro Phe Thr Asn Tyr Met Ser Tyr Thr Asp Asp Asn Cys Thr Asp 
                805                 810                 815     


Asn Phe Thr Pro Asn Gln Val Ala Arg Met His Cys Tyr Leu Asp Leu 
            820                 825                 830         


Val Tyr Gln Gln Trp Thr Glu Ser Arg Lys Pro Thr Pro Ile Pro Ile 
        835                 840                 845             


Pro Pro Met Val Ile Gly Gln Thr Asn Lys Ser Leu Thr Ile His Trp 
    850                 855                 860                 


Leu Pro Pro Ile Ser Gly Val Val Tyr Asp Arg Ala Ser Gly Ser Leu 
865                 870                 875                 880 


Cys Gly Ala Cys Thr Glu Asp Gly Thr Phe Arg Gln Tyr Val His Thr 
                885                 890                 895     


Ala Ser Ser Arg Arg Val Cys Asp Ser Ser Gly Tyr Trp Thr Pro Glu 
            900                 905                 910         


Glu Ala Val Gly Pro Pro Asp Val Asp Gln Pro Cys Glu Pro Ser Leu 
        915                 920                 925             


Gln Ala Trp Ser Pro Glu Val His Leu Tyr His Met Asn Met Thr Val 
    930                 935                 940                 


Pro Cys Pro Thr Glu Gly Cys Ser Leu Glu Leu Leu Phe Gln His Pro 
945                 950                 955                 960 


Val Gln Ala Asp Thr Leu Thr Leu Trp Val Thr Ser Phe Phe Met Glu 
                965                 970                 975     


Ser Ser Gln Val Leu Phe Asp Thr Glu Ile Leu Leu Glu Asn Lys Glu 
            980                 985                 990         


Ser Val His Leu Gly Pro Leu Asp  Thr Phe Cys Asp Ile  Pro Leu Thr 
        995                 1000                 1005             


Ile Lys  Leu His Val Asp Gly  Lys Val Ser Gly Val  Lys Val Tyr 
    1010                 1015                 1020             


Thr Phe  Asp Glu Arg Ile Glu  Ile Asp Ala Ala Leu  Leu Thr Ser 
    1025                 1030                 1035             


Gln Pro  His Ser Pro Leu Cys  Ser Gly Cys Arg Pro  Val Arg Tyr 
    1040                 1045                 1050             


Gln Val  Leu Arg Asp Pro Pro  Phe Ala Ser Gly Leu  Pro Val Val 
    1055                 1060                 1065             


Val Thr  His Ser His Arg Lys  Phe Thr Asp Val Glu  Val Thr Pro 
    1070                 1075                 1080             


Gly Gln  Met Tyr Gln Tyr Gln  Val Leu Ala Glu Ala  Gly Gly Glu 
    1085                 1090                 1095             


Leu Gly  Glu Ala Ser Pro Pro  Leu Asn His Ile His  Gly Ala Pro 
    1100                 1105                 1110             


Tyr Cys  Gly Asp Gly Lys Val  Ser Glu Arg Leu Gly  Glu Glu Cys 
    1115                 1120                 1125             


Asp Asp  Gly Asp Leu Val Ser  Gly Asp Gly Cys Ser  Lys Val Cys 
    1130                 1135                 1140             


Glu Leu  Glu Glu Gly Phe Asn  Cys Val Gly Glu Pro  Ser Leu Cys 
    1145                 1150                 1155             


Tyr Met  Tyr Glu Gly Asp Gly  Ile Cys Glu Pro Phe  Glu Arg Lys 
    1160                 1165                 1170             


Thr Ser  Ile Val Asp Cys Gly  Ile Tyr Thr Pro Lys  Gly Tyr Leu 
    1175                 1180                 1185             


Asp Gln  Trp Ala Thr Arg Ala  Tyr Ser Ser His Glu  Asp Lys Lys 
    1190                 1195                 1200             


Lys Cys  Pro Val Ser Leu Val  Thr Gly Glu Pro His  Ser Leu Ile 
    1205                 1210                 1215             


Cys Thr  Ser Tyr His Pro Asp  Leu Pro Asn His Arg  Pro Leu Thr 
    1220                 1225                 1230             


Gly Trp  Phe Pro Cys Val Ala  Ser Glu Asn Glu Thr  Gln Asp Asp 
    1235                 1240                 1245             


Arg Ser  Glu Gln Pro Glu Gly  Ser Leu Lys Lys Glu  Asp Glu Val 
    1250                 1255                 1260             


Trp Leu  Lys Val Cys Phe Asn  Arg Pro Gly Glu Ala  Arg Ala Ile 
    1265                 1270                 1275             


Phe Ile  Phe Leu Thr Thr Asp  Gly Leu Val Pro Gly  Glu His Gln 
    1280                 1285                 1290             


Gln Pro  Thr Val Thr Leu Tyr  Leu Thr Asp Val Arg  Gly Ser Asn 
    1295                 1300                 1305             


His Ser  Leu Gly Thr Tyr Gly  Leu Ser Cys Gln His  Asn Pro Leu 
    1310                 1315                 1320             


Ile Ile  Asn Val Thr His His  Gln Asn Val Leu Phe  His His Thr 
    1325                 1330                 1335             


Thr Ser  Val Leu Leu Asn Phe  Ser Ser Pro Arg Val  Gly Ile Ser 
    1340                 1345                 1350             


Ala Val  Ala Leu Arg Thr Ser  Ser Arg Ile Gly Leu  Ser Ala Pro 
    1355                 1360                 1365             


Ser Asn  Cys Ile Ser Glu Asp  Glu Gly Gln Asn His  Gln Gly Gln 
    1370                 1375                 1380             


Ser Cys  Ile His Arg Pro Cys  Gly Lys Gln Asp Ser  Cys Pro Ser 
    1385                 1390                 1395             


Leu Leu  Leu Asp His Ala Asp  Val Val Asn Cys Thr  Ser Ile Gly 
    1400                 1405                 1410             


Pro Gly  Leu Met Lys Cys Ala  Ile Thr Cys Gln Arg  Gly Phe Ala 
    1415                 1420                 1425             


Leu Gln  Ala Ser Ser Gly Gln  Tyr Ile Arg Pro Met  Gln Lys Glu 
    1430                 1435                 1440             


Ile Leu  Leu Thr Cys Ser Ser  Gly His Trp Asp Gln  Asn Val Ser 
    1445                 1450                 1455             


Cys Leu  Pro Val Asp Cys Gly  Val Pro Asp Pro Ser  Leu Val Asn 
    1460                 1465                 1470             


Tyr Ala  Asn Phe Ser Cys Ser  Glu Gly Thr Lys Phe  Leu Lys Arg 
    1475                 1480                 1485             


Cys Ser  Ile Ser Cys Val Pro  Pro Ala Lys Leu Gln  Gly Leu Ser 
    1490                 1495                 1500             


Pro Trp  Leu Thr Cys Leu Glu  Asp Gly Leu Trp Ser  Leu Pro Glu 
    1505                 1510                 1515             


Val Tyr  Cys Lys Leu Glu Cys  Asp Ala Pro Pro Ile  Ile Leu Asn 
    1520                 1525                 1530             


Ala Asn  Leu Leu Leu Pro His  Cys Leu Gln Asp Asn  His Asp Val 
    1535                 1540                 1545             


Gly Thr  Ile Cys Lys Tyr Glu  Cys Lys Pro Gly Tyr  Tyr Val Ala 
    1550                 1555                 1560             


Glu Ser  Ala Glu Gly Lys Val  Arg Asn Lys Leu Leu  Lys Ile Gln 
    1565                 1570                 1575             


Cys Leu  Glu Gly Gly Ile Trp  Glu Gln Gly Ser Cys  Ile Pro Val 
    1580                 1585                 1590             


Val Cys  Glu Pro Pro Pro Pro  Val Phe Glu Gly Met  Tyr Glu Cys 
    1595                 1600                 1605             


Thr Asn  Gly Phe Ser Leu Asp  Ser Gln Cys Val Leu  Asn Cys Asn 
    1610                 1615                 1620             


Gln Glu  Arg Glu Lys Leu Pro  Ile Leu Cys Thr Lys  Glu Gly Leu 
    1625                 1630                 1635             


Trp Thr  Gln Glu Phe Lys Leu  Cys Glu Asn Leu Gln  Gly Glu Cys 
    1640                 1645                 1650             


Pro Pro  Pro Pro Ser Glu Leu  Asn Ser Val Glu Tyr  Lys Cys Glu 
    1655                 1660                 1665             


Gln Gly  Tyr Gly Ile Gly Ala  Val Cys Ser Pro Leu  Cys Val Ile 
    1670                 1675                 1680             


Pro Pro  Ser Asp Pro Val Met  Leu Pro Glu Asn Ile  Thr Ala Asp 
    1685                 1690                 1695             


Thr Leu  Glu His Trp Met Glu  Pro Val Lys Val Gln  Ser Ile Val 
    1700                 1705                 1710             


Cys Thr  Gly Arg Arg Gln Trp  His Pro Asp Pro Val  Leu Val His 
    1715                 1720                 1725             


Cys Ile  Gln Ser Cys Glu Pro  Phe Gln Ala Asp Gly  Trp Cys Asp 
    1730                 1735                 1740             


Thr Ile  Asn Asn Arg Ala Tyr  Cys His Tyr Asp Gly  Gly Asp Cys 
    1745                 1750                 1755             


Cys Ser  Ser Thr Leu Ser Ser  Lys Lys Val Ile Pro  Phe Ala Ala 
    1760                 1765                 1770             


Asp Cys  Asp Leu Asp Glu Cys  Thr Cys Arg Asp Pro  Lys Ala Glu 
    1775                 1780                 1785             


Glu Asn  Gln 
    1790     


<210>  6729
<211>  472
<212>  DNA
<213>  Homosapiens

<400>  6729
agtcacatga ccaagtgttg atttttctgg aggaaaaatt ttatggaaat gatatagggg     60

aaaggtggga ggagatgaaa gaacaggcaa gagctgtcag ggttaaatcc aggtggccca    120

gggctagctg gctctaacaa ctagcatgac agcctccaat cagaaaggca ggtaagggga    180

cagggtgagg agaatgggca gatactgaca gaaattaaag taaagggatt gtgaaagtaa    240

agagctcttc ctgattctca tcttctcttt tttctattac aaggcattga acttggcact    300

tcctgtattc tttgtgatca ctattgagtg cattagttaa cacccaaggg gatggcttga    360

ttgggaatgt agtgaaagga gctgatctac tgtattgtaa tgtaaaacag ctacagccag    420

ttattttgta agattataag ttgttcatta aaaaatcagc acacaaaata tg            472


<210>  6730
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  6730

Arg Asp Cys Glu Ser Lys Glu Leu Phe Leu Ile Leu Ile Phe Ser Phe 
1               5                   10                  15      


Phe Tyr Tyr Lys Ala Leu Asn Leu Ala Leu Pro Val Phe Phe Val Ile 
            20                  25                  30          


Thr Ile Glu Cys Ile Ser 
        35              


<210>  6731
<211>  4207
<212>  DNA
<213>  Homosapiens

<400>  6731
gctccgggaa acaaagaatc cggggctctc cagacatcag agcttaaacc caggactctg     60

caagcggcat ctcattccgg ggtccagggc tctcccggct ctccatcccc tccctaacct    120

cccccgcctc ccgcgctcgc tccctcgctc cctccccgct cgcttcctcc cccaccatcg    180

cagcgctagg aggaaggcgg ccggggctca agatggcttt agccgggctc tgcgccctgc    240

tcgcctgctg ctgggggccg gcggcggtgc tggccacggc cgccggcgac gtggatccat    300

ccaaggagct ggagtgcaag ctcaaaagca tcacggtgtc ggcactgccc ttcctgcgcg    360

agaacgacct gagcatcatg cacagcccct cggcctcgga gcccaagctc ctcttctcgg    420

tgcgcaacga cttcccggga gaaatggtcg tggtggacga cctggagaac acggagctgc    480

cctacttcgt gctggagatc tcagggaaca cagaggatat ccctttggtg cgctggaggc    540

agcagtggct ggagaatggc actttgcttt ttcacattca tcaccaagat ggtgccccaa    600

gccttcctgg acaagacccc actgaagaac cccaacatga gtcggcagaa gaggagctga    660

ggatcctcca catctcagtc atgggtggca tgatcgctct gctgctgtcc atcttgtgcc    720

tggtgatgat cctgtatact cgccggcgct ggtgcaaacg ccgccgggtc ccgcagcccc    780

agaagagtgc cagtgctgag gcagccaatg agattcacta cattccttct gtgctgatcg    840

gcgggcacgg acgggagagc ctgcgcaatg cccgcgtgca gggccacaac tccagtggca    900

ccctgagcat ccgggagaca cctatcctgg acggctatga gtatgacatc actgatctgc    960

gccaccatct gcagagggag tgcatgaacg gaggggagga ctttgccagc caggtcacgc   1020

gcaccctcga ctccctgcag ggctgcaatg aaaagtcggg gatggacctc acaccaggaa   1080

gtgacaatgc caagctgtca ctgatgaaca agtataaaga taatattata gccactagcc   1140

ctgtggactc caaccaccag caagccaccc ttctctctca cacctccagc agccagagaa   1200

agcggatcaa caacaaagca agagctggtt ccgccttctt gaaccctgaa ggggattctg   1260

gcacagaggc agaaaacgac ccccagctga ccttttacac ggatccttca aggagcagga   1320

ggcgtagtag agtgggttct ccccgaagtc ctgtgaataa gaccaccttg accctgatca   1380

gcatcaccag ctgtgtgatt ggcctcgtgt gctcctctca cgtcaactgc cctctcgttg   1440

tcaagatcac cctgcatgtc cctgagcacc tgattgctga tgggagccgc ttcatcttgc   1500

tggaggggag ccagctggat gccagtgact ggctgaaccc tgcccaagtg gttctcttct   1560

ctcagcagaa ctccagcgga ccctgggcca tggacctctg tgcccggcgg ctcctggacc   1620

cctgtgaaca ccaatgtgac cccgaaactg gggaatgcct ctgctatgaa ggctacatga   1680

aggatccagt acataagcac ctttgcattc ggaacgaatg ggggacaaac caggggccat   1740

ggccttacac aatatttcag cgaggctttg acctggtttt gggagagcag ccctctgata   1800

aaatatttag attcacctac actcttgggg agggcatgtg gttgcccctc agcaagagct   1860

ttgtgattcc accagccgaa ctggccatca atccatcagc aaagtgcaag acggacatga   1920

ctgtgatgga ggatgctgtg gaggtcagag aggagctgat gacttcatcc tccttcgaca   1980

gcctggaggt tctcttagat tcctttgggc cggtgcgcga ctgcagcaaa gataacgggg   2040

gctgcagtaa gaatttccgc tgtatttcag atcgcaagct ggactccact ggttgcgtgt   2100

gcccatctgg actcagtccc atgaaggaca gctctggctg ctatgaccgc cacatcgggg   2160

tggactgttc cgacggcttc aacggcggct gtgagcagct gtgcctccag cagatggcgc   2220

ccttcccgga cgaccccacc ttgtataaca tcctcatgtt ctgtgggtgc atcgaggact   2280

acaagcttgg tgtggatgga cgctcttgcc aactcatcac ggagacctgt ccagagggaa   2340

gtgactgtgg ggaaagcagg gagcttccca tgaaccagac cctctttggg gagatgttct   2400

ttggttacaa caaccattcc aaggaagtgg ctgccggaca ggtgctgaaa ggaacattca   2460

ggcaaaacaa ctttgctcgt ggtttagacc agcaactgcc agatggtctt gtggtggcca   2520

ctgtgcccct ggagaatcaa tgcctagagg agatctcgga gcccacccct gaccctgact   2580

tcctgactgg gatggtgaac ttcagtgaag tgtctgggta ccctgtgctg cagcactgga   2640

aggtccggtc tgtgatgtac cacatcaaac tcaaccaagt ggccatctct caggccctca   2700

gcaatgctct ccactcgctg gatggggcta catctcgtgc agattttgtg gcgctgttgg   2760

accagttcgg caaccattac atccaggaag ctatctacgg ctttgaggag tcctgttcta   2820

tctggtaccc aaacaagcag gtccagcggc gactctggct ggagtatgaa gacatcagta   2880

aaggcaactc cccatcagat gagtctgagg agcgggaaag agaccccaag gtgctgacat   2940

tcccagaata catcaccagc ttgtcagact ccggcaccaa gcacatggcg gctggagtcc   3000

gcatggagtg ccacagcaag ggacgatgcc cctcgtcctg ccccctgtgt catgtgacat   3060

ccagccctga cacccctgct gagccggttc tgctggaggt gaccaaagca gcccccatct   3120

atgaactagt gaccaacaac cagacccaga ggctcttgca ggaggctacc atgagctctc   3180

tctggtgctc agggactgga gatgtcatcg aggactggtg tcgatgtgac tccactgctt   3240

ttggagctga tggactcccc acctgtgcgc ctctcccaca gcctgtgctg agactctcca   3300

cggttcacga gcccagcagc actcttgtgg tcctggagtg ggaacactca gagccaccaa   3360

tcggggtgca gattgtagat tacctcctcc gtcaagagaa agtcactgac aggatggacc   3420

actccaaagt ggagacagaa acagtgctga gctttgtgga cgacatcatc tctggagcaa   3480

agtctccttg tgcaatgcca tctcaggtgc cggacaagca gctcaccacc atctctctga   3540

tcatacgatg cctggaacct gacaccattt acatgttcac gctgtgggga gtggacaaca   3600

caggacggcg ctccaggcca agcgacgtga tcgtgaagac cccatgcccc gtggtggatg   3660

atgtcaaggc tcaagaaata gcagacaaga tctacaatct cttcaatggc tacactagtg   3720

ggaaggagca gcagaccgcc tacaacaccc tcctggatct gggttccccc accttacacc   3780

gggtcctcta ccactataac cagcactatg agagttttgg ggaattcacc tggcgatgtg   3840

aggatgagtt aggtcccagg cttccagcgt gttgggacag tcagaggagt tgtagatgat   3900

tggaggaaag gaagaagacg gcagccaggg tatttcccct tctccctgcc tcagatggca   3960

tctccagcat ctccttcatg acctctgtct cctccgtgtg accttccatc ccctcaaagc   4020

aggagctgcg ccctgatgtt gctaatctga taggttgctc ctatttgtcc ttctataatc   4080

ccaaagtctt cctaattggt ttctcatctt gaacttcctc tgtggaatta cctaaaatgt   4140

attttgcttt cctgactagg tcttgattaa tatatacttc aaactaaaag ttagtacata   4200

tcgtctg                                                             4207


<210>  6732
<211>  1228
<212>  PRT
<213>  Homosapiens

<400>  6732

Met Ala Leu Ala Gly Leu Cys Ala Leu Leu Ala Cys Cys Trp Gly Pro 
1               5                   10                  15      


Ala Ala Val Leu Ala Thr Ala Ala Gly Asp Val Asp Pro Ser Lys Glu 
            20                  25                  30          


Leu Glu Cys Lys Leu Lys Ser Ile Thr Val Ser Ala Leu Pro Phe Leu 
        35                  40                  45              


Arg Glu Asn Asp Leu Ser Ile Met His Ser Pro Ser Ala Ser Glu Pro 
    50                  55                  60                  


Lys Leu Leu Phe Ser Val Arg Asn Asp Phe Pro Gly Glu Met Val Val 
65                  70                  75                  80  


Val Asp Asp Leu Glu Asn Thr Glu Leu Pro Tyr Phe Val Leu Glu Ile 
                85                  90                  95      


Ser Gly Asn Thr Glu Asp Ile Pro Leu Val Arg Trp Arg Gln Gln Trp 
            100                 105                 110         


Leu Glu Asn Gly Thr Leu Leu Phe His Ile His His Gln Asp Gly Ala 
        115                 120                 125             


Pro Ser Leu Pro Gly Gln Asp Pro Thr Glu Glu Pro Gln His Glu Ser 
    130                 135                 140                 


Ala Glu Glu Glu Leu Arg Ile Leu His Ile Ser Val Met Gly Gly Met 
145                 150                 155                 160 


Ile Ala Leu Leu Leu Ser Ile Leu Cys Leu Val Met Ile Leu Tyr Thr 
                165                 170                 175     


Arg Arg Arg Trp Cys Lys Arg Arg Arg Val Pro Gln Pro Gln Lys Ser 
            180                 185                 190         


Ala Ser Ala Glu Ala Ala Asn Glu Ile His Tyr Ile Pro Ser Val Leu 
        195                 200                 205             


Ile Gly Gly His Gly Arg Glu Ser Leu Arg Asn Ala Arg Val Gln Gly 
    210                 215                 220                 


His Asn Ser Ser Gly Thr Leu Ser Ile Arg Glu Thr Pro Ile Leu Asp 
225                 230                 235                 240 


Gly Tyr Glu Tyr Asp Ile Thr Asp Leu Arg His His Leu Gln Arg Glu 
                245                 250                 255     


Cys Met Asn Gly Gly Glu Asp Phe Ala Ser Gln Val Thr Arg Thr Leu 
            260                 265                 270         


Asp Ser Leu Gln Gly Cys Asn Glu Lys Ser Gly Met Asp Leu Thr Pro 
        275                 280                 285             


Gly Ser Asp Asn Ala Lys Leu Ser Leu Met Asn Lys Tyr Lys Asp Asn 
    290                 295                 300                 


Ile Ile Ala Thr Ser Pro Val Asp Ser Asn His Gln Gln Ala Thr Leu 
305                 310                 315                 320 


Leu Ser His Thr Ser Ser Ser Gln Arg Lys Arg Ile Asn Asn Lys Ala 
                325                 330                 335     


Arg Ala Gly Ser Ala Phe Leu Asn Pro Glu Gly Asp Ser Gly Thr Glu 
            340                 345                 350         


Ala Glu Asn Asp Pro Gln Leu Thr Phe Tyr Thr Asp Pro Ser Arg Ser 
        355                 360                 365             


Arg Arg Arg Ser Arg Val Gly Ser Pro Arg Ser Pro Val Asn Lys Thr 
    370                 375                 380                 


Thr Leu Thr Leu Ile Ser Ile Thr Ser Cys Val Ile Gly Leu Val Cys 
385                 390                 395                 400 


Ser Ser His Val Asn Cys Pro Leu Val Val Lys Ile Thr Leu His Val 
                405                 410                 415     


Pro Glu His Leu Ile Ala Asp Gly Ser Arg Phe Ile Leu Leu Glu Gly 
            420                 425                 430         


Ser Gln Leu Asp Ala Ser Asp Trp Leu Asn Pro Ala Gln Val Val Leu 
        435                 440                 445             


Phe Ser Gln Gln Asn Ser Ser Gly Pro Trp Ala Met Asp Leu Cys Ala 
    450                 455                 460                 


Arg Arg Leu Leu Asp Pro Cys Glu His Gln Cys Asp Pro Glu Thr Gly 
465                 470                 475                 480 


Glu Cys Leu Cys Tyr Glu Gly Tyr Met Lys Asp Pro Val His Lys His 
                485                 490                 495     


Leu Cys Ile Arg Asn Glu Trp Gly Thr Asn Gln Gly Pro Trp Pro Tyr 
            500                 505                 510         


Thr Ile Phe Gln Arg Gly Phe Asp Leu Val Leu Gly Glu Gln Pro Ser 
        515                 520                 525             


Asp Lys Ile Phe Arg Phe Thr Tyr Thr Leu Gly Glu Gly Met Trp Leu 
    530                 535                 540                 


Pro Leu Ser Lys Ser Phe Val Ile Pro Pro Ala Glu Leu Ala Ile Asn 
545                 550                 555                 560 


Pro Ser Ala Lys Cys Lys Thr Asp Met Thr Val Met Glu Asp Ala Val 
                565                 570                 575     


Glu Val Arg Glu Glu Leu Met Thr Ser Ser Ser Phe Asp Ser Leu Glu 
            580                 585                 590         


Val Leu Leu Asp Ser Phe Gly Pro Val Arg Asp Cys Ser Lys Asp Asn 
        595                 600                 605             


Gly Gly Cys Ser Lys Asn Phe Arg Cys Ile Ser Asp Arg Lys Leu Asp 
    610                 615                 620                 


Ser Thr Gly Cys Val Cys Pro Ser Gly Leu Ser Pro Met Lys Asp Ser 
625                 630                 635                 640 


Ser Gly Cys Tyr Asp Arg His Ile Gly Val Asp Cys Ser Asp Gly Phe 
                645                 650                 655     


Asn Gly Gly Cys Glu Gln Leu Cys Leu Gln Gln Met Ala Pro Phe Pro 
            660                 665                 670         


Asp Asp Pro Thr Leu Tyr Asn Ile Leu Met Phe Cys Gly Cys Ile Glu 
        675                 680                 685             


Asp Tyr Lys Leu Gly Val Asp Gly Arg Ser Cys Gln Leu Ile Thr Glu 
    690                 695                 700                 


Thr Cys Pro Glu Gly Ser Asp Cys Gly Glu Ser Arg Glu Leu Pro Met 
705                 710                 715                 720 


Asn Gln Thr Leu Phe Gly Glu Met Phe Phe Gly Tyr Asn Asn His Ser 
                725                 730                 735     


Lys Glu Val Ala Ala Gly Gln Val Leu Lys Gly Thr Phe Arg Gln Asn 
            740                 745                 750         


Asn Phe Ala Arg Gly Leu Asp Gln Gln Leu Pro Asp Gly Leu Val Val 
        755                 760                 765             


Ala Thr Val Pro Leu Glu Asn Gln Cys Leu Glu Glu Ile Ser Glu Pro 
    770                 775                 780                 


Thr Pro Asp Pro Asp Phe Leu Thr Gly Met Val Asn Phe Ser Glu Val 
785                 790                 795                 800 


Ser Gly Tyr Pro Val Leu Gln His Trp Lys Val Arg Ser Val Met Tyr 
                805                 810                 815     


His Ile Lys Leu Asn Gln Val Ala Ile Ser Gln Ala Leu Ser Asn Ala 
            820                 825                 830         


Leu His Ser Leu Asp Gly Ala Thr Ser Arg Ala Asp Phe Val Ala Leu 
        835                 840                 845             


Leu Asp Gln Phe Gly Asn His Tyr Ile Gln Glu Ala Ile Tyr Gly Phe 
    850                 855                 860                 


Glu Glu Ser Cys Ser Ile Trp Tyr Pro Asn Lys Gln Val Gln Arg Arg 
865                 870                 875                 880 


Leu Trp Leu Glu Tyr Glu Asp Ile Ser Lys Gly Asn Ser Pro Ser Asp 
                885                 890                 895     


Glu Ser Glu Glu Arg Glu Arg Asp Pro Lys Val Leu Thr Phe Pro Glu 
            900                 905                 910         


Tyr Ile Thr Ser Leu Ser Asp Ser Gly Thr Lys His Met Ala Ala Gly 
        915                 920                 925             


Val Arg Met Glu Cys His Ser Lys Gly Arg Cys Pro Ser Ser Cys Pro 
    930                 935                 940                 


Leu Cys His Val Thr Ser Ser Pro Asp Thr Pro Ala Glu Pro Val Leu 
945                 950                 955                 960 


Leu Glu Val Thr Lys Ala Ala Pro Ile Tyr Glu Leu Val Thr Asn Asn 
                965                 970                 975     


Gln Thr Gln Arg Leu Leu Gln Glu Ala Thr Met Ser Ser Leu Trp Cys 
            980                 985                 990         


Ser Gly Thr Gly Asp Val Ile Glu  Asp Trp Cys Arg Cys  Asp Ser Thr 
        995                 1000                 1005             


Ala Phe  Gly Ala Asp Gly Leu  Pro Thr Cys Ala Pro  Leu Pro Gln 
    1010                 1015                 1020             


Pro Val  Leu Arg Leu Ser Thr  Val His Glu Pro Ser  Ser Thr Leu 
    1025                 1030                 1035             


Val Val  Leu Glu Trp Glu His  Ser Glu Pro Pro Ile  Gly Val Gln 
    1040                 1045                 1050             


Ile Val  Asp Tyr Leu Leu Arg  Gln Glu Lys Val Thr  Asp Arg Met 
    1055                 1060                 1065             


Asp His  Ser Lys Val Glu Thr  Glu Thr Val Leu Ser  Phe Val Asp 
    1070                 1075                 1080             


Asp Ile  Ile Ser Gly Ala Lys  Ser Pro Cys Ala Met  Pro Ser Gln 
    1085                 1090                 1095             


Val Pro  Asp Lys Gln Leu Thr  Thr Ile Ser Leu Ile  Ile Arg Cys 
    1100                 1105                 1110             


Leu Glu  Pro Asp Thr Ile Tyr  Met Phe Thr Leu Trp  Gly Val Asp 
    1115                 1120                 1125             


Asn Thr  Gly Arg Arg Ser Arg  Pro Ser Asp Val Ile  Val Lys Thr 
    1130                 1135                 1140             


Pro Cys  Pro Val Val Asp Asp  Val Lys Ala Gln Glu  Ile Ala Asp 
    1145                 1150                 1155             


Lys Ile  Tyr Asn Leu Phe Asn  Gly Tyr Thr Ser Gly  Lys Glu Gln 
    1160                 1165                 1170             


Gln Thr  Ala Tyr Asn Thr Leu  Leu Asp Leu Gly Ser  Pro Thr Leu 
    1175                 1180                 1185             


His Arg  Val Leu Tyr His Tyr  Asn Gln His Tyr Glu  Ser Phe Gly 
    1190                 1195                 1200             


Glu Phe  Thr Trp Arg Cys Glu  Asp Glu Leu Gly Pro  Arg Leu Pro 
    1205                 1210                 1215             


Ala Cys  Trp Asp Ser Gln Arg  Ser Cys Arg 
    1220                 1225             


<210>  6733
<211>  7444
<212>  DNA
<213>  Homosapiens

<400>  6733
ggggtctcta gtgacccgag gcttccggag gaggctgccc ttgctccgcg gtccctcgcg     60

gctcaaatcc gaaaggtcgg agatttcaga aagaagaggc gtgtgcaggg cgcctcccaa    120

gaccccgcca gccgccggca cacccagcat ctttgaagtg gggcttcggc actgggccgg    180

ggcgcacgcg gggcggccgg ggctcaagat ggctttagcc gggctctgcg ccctgctcgc    240

ctgctgctgg gggccggcgg cggtgctggc cacggccgcc ggcgacgtgg atccatccaa    300

ggagctggag tgcaagctca aaagcatcac ggtgtcggca ctgcccttcc tgcgcgagaa    360

cgacctgagc atcatgcaca gcccctcggc ctcggagccc aagctcctct tctcggtgcg    420

caacgacttc ccgggagaaa tggtcgtggt ggacgacctg gagaacacgg agctgcccta    480

cttcgtgctg gagatctcag ggaacacaga ggatatccct ttggtgcgct ggaggcagca    540

gtggctggag aatggcactt tgctttttca cattcatcac caagatggtg ccccaagcct    600

tcctggacaa gaccccactg aagaacccca acatgagtcg gcagaagagg agctgaggat    660

cctccacatc tcagtcatgg gtggcatgat cgctctgctg ctgtccatct tgtgcctggt    720

gatgatcctg tatactcgcc ggcgctggtg caaacgccgc cgggtcccgc agccccagaa    780

gagtgccagt gctgaggcag ccaatgagat tcactacatt ccttctgtgc tgatcggcgg    840

gcacggacgg gagagcctgc gcaatgcccg cgtgcagggc cacaactcca gtggcaccct    900

gagcatccgg gagacaccta tcctggacgg ctatgagtat gacatcactg atctgcgcca    960

ccatctgcag agggagtgca tgaacggagg ggaggacttt gccagccagg tcacgcgcac   1020

cctcgactcc ctgcagggct gcaatgaaaa gtcggggatg gacctcacac caggaagtga   1080

caatgccaag ctgtcactga tgaacaagta taaagataat attatagcca ctagccctgt   1140

ggactccaac caccagcaag ccacccttct ctctcacacc tccagcagcc agagaaagcg   1200

gatcaacaac aaagcaagag ctggttccgc cttcttgaac cctgaagggg attctggcac   1260

agaggcagaa aacgaccccc agctgacctt ttacacggat ccttcaagga gcaggaggcg   1320

tagtagagtg ggttctcccc gaagtcctgt gaataagacc accttgaccc tgatcagcat   1380

caccagctgt gtgattggcc tcgtgtgctc ctctcacgtc aactgccctc tcgttgtcaa   1440

gatcaccctg catgtccctg agcacctgat tgctgatggg agccgcttca tcttgctgga   1500

ggggagccag ctggatgcca gtgactggct gaaccctgcc caagtggttc tcttctctca   1560

gcagaactcc agcggaccct gggccatgga cctctgtgcc cggcggctcc tggacccctg   1620

tgaacaccaa tgtgaccccg aaactgggga atgcctctgc tatgaaggct acatgaagga   1680

tccagtacat aagcaccttt gcattcggaa cgaatggggg acaaaccagg ggccatggcc   1740

ttacacaata tttcagcgag gctttgacct ggttttggga gagcagccct ctgataaaat   1800

atttagattc acctacactc ttggggaggg catgtggttg cccctcagca agagctttgt   1860

gattccacca gccgaactgg ccatcaatcc atcagcaaag tgcaagacgg acatgactgt   1920

gatggaggat gctgtggagg tcagagagga gctgatgact tcatcctcct tcgacagcct   1980

ggaggttctc ttagattcct ttgggccggt gcgcgactgc agcaaagata acgggggctg   2040

cagtaagaat ttccgctgta tttcagatcg caagctggac tccactggtt gcgtgtgccc   2100

atctggactc agtcccatga aggacagctc tggctgctat gaccgccaca tcggggtgga   2160

ctgttccgac ggcttcaacg gcggctgtga gcagctgtgc ctccagcaga tggcgccctt   2220

cccggacgac cccaccttgt ataacatcct catgttctgt gggtgcatcg aggactacaa   2280

gcttggtgtg gatggacgct cttgccaact catcacggag acctgtccag agggaagtga   2340

ctgtggggaa agcagggagc ttcccatgaa ccagaccctc tttggggaga tgttctttgg   2400

ttacaacaac cattccaagg aagtggctgc cggacaggtg ctgaaaggaa cattcaggca   2460

aaacaacttt gctcgtggtt tagaccagca actgccagat ggtcttgtgg tggccactgt   2520

gcccctggag aatcaatgcc tagaggagat ctcggagccc acccctgacc ctgacttcct   2580

gactgggatg gtgaacttca gtgaagtgtc tgggtaccct gtgctgcagc actggaaggt   2640

ccggtctgtg atgtaccaca tcaaactcaa ccaagtggcc atctctcagg ccctcagcaa   2700

tgctctccac tcgctggatg gggctacatc tcgtgcagat tttgtggcgc tgttggacca   2760

gttcggcaac cattacatcc aggaagctat ctacggcttt gaggagtcct gttctatctg   2820

gtacccaaac aagcaggtcc agcggcgact ctggctggag tatgaagaca tcagtaaagg   2880

caactcccca tcagatgagt ctgaggagcg ggaaagagac cccaaggtgc tgacattccc   2940

agaatacatc accagcttgt cagactccgg caccaagcac atggcggctg gagtccgcat   3000

ggagtgccac agcaagggac gatgcccctc gtcctgcccc ctgtgtcatg tgacatccag   3060

ccctgacacc cctgctgagc cggttctgct ggaggtgacc aaagcagccc ccatctatga   3120

actagtgacc aacaaccaga cccagaggct cttgcaggag gctaccatga gctctctctg   3180

gtgctcaggg actggagatg tcatcgagga ctggtgtcga tgtgactcca ctgcttttgg   3240

agctgatgga ctccccacct gtgcgcctct cccacagcct gtgctgagac tctccacggt   3300

tcacgagccc agcagcactc ttgtggtcct ggagtgggaa cactcagagc caccaatcgg   3360

ggtgcagatt gtagattacc tcctccgtca agagaaagtc actgacagga tggaccactc   3420

caaagtggag acagaaacag tgctgagctt tgtggacgac atcatctctg gagcaaagtc   3480

tccttgtgca atgccatctc aggtgccgga caagcagctc accaccatct ctctgatcat   3540

acgatgcctg gaacctgaca ccatttacat gttcacgctg tggggagtgg acaacacagg   3600

acggcgctcc aggccaagcg acgtgatcgt gaagacccca tgccccgtgg tggatgatgt   3660

caaggctcaa gaaatagcag acaagatcta caatctcttc aatggctaca ctagtgggaa   3720

ggagcagcag accgcctaca acaccctcct ggatctgggt tcccccacct tacaccgggt   3780

cctctaccac tataaccagc actatgagag ttttggggaa ttcacctggc gatgtgagga   3840

tgagttaggt cccaggaaag ctggtctcat cctttcccag cttggggacc tcagcagttg   3900

gtgcaatgga ctccttcagg aacccaagat aagcttgcgg cgcagctcac tcaagtacct   3960

ggggtgccgc tacagcgaga tcaaacccta cggacttgac tgggcggagc tcagccggga   4020

cctcaggaag acgtgtgagg agcagaccct gagtatcccc tacaacgact atggggacag   4080

caaagagatc tagcaccata aggccaggga gctgctgcca gaatgaagta ggaaagagga   4140

gggatccatc tgggttggtc tgtggatttt taatattttt taatggaaca tgaaaacctc   4200

cacagcaaca tcgaaaccag ggagaaagtg atccttgctc cctgcagaac ttcttcagta   4260

tgatgttctc catctgcatg attgggaaat ctgccagcca gtggcttcat gcagtgccat   4320

atttctttag aggattactt tggggtttgc tttgccatta atttgttcca ttcatttttt   4380

tttccctgag aagtttacca aaatgctcaa gagctctgcc gtgctcccca tgaaaagtct   4440

attaagtagg caccctgtgc tcactcagtt cctaaatcca ttgcaactgg gagcagaggt   4500

gaggccagaa agttgttagg cctgccgcag gccccaccct caagcattcc tcaggaagcg   4560

tctcactctg ggagccttgg ccctgctcac agagagagac aatagaaaat tgaggaaggt   4620

ggcccttgtc tgtgtctcct ggttttcttc ctaggccttg ctatcactat ttccataccc   4680

gaaaggtgaa accagctttc attataggcc ccagtgggcc acttgggttt tgagatcctt   4740

ccttatttta agccaggact gggattaaat ctccctctgt cagatctctg tcccttcctc   4800

tgaacaacat gatctttgag agggaacaag atgccatctg tcaactgcac cttcagaaaa   4860

gtctacctgg gagactagtt agcagtccac attcaagagg agacttggag tttattgttt   4920

tttaaaaaaa ccatgcttcc tttggataga cttctccagc ctaccaatat atatccatgt   4980

gcctggatta tctttaaccc ccacacctct taccttggac aggtaaggct tggccgatgt   5040

ctgattggga ccaggagggg tcaacacttt catatcagtg ttacagtgaa ctaaagctat   5100

tattgatcac aaaaaacttc tgttcatccc caccttgcta aatttgcttg tgttgctagt   5160

tttgcaaatc gtttctctga tgaccataag caggaggatt ccaccatggt cactgcccat   5220

ccagtcacag ggattctgtg tagggaagca ccactgattg cagttaacat ctagagtgtt   5280

gtttccatcc cactgcccaa gcattggcat ggtcatgaat ggtggcccag ccaacaggaa   5340

gcccagcctt tcagaaagag cctggcaagg ccctgttgac tagcaatggc cttagctgtc   5400

ccacacaact cagtggcctg aacacacacc ttcagccacc atgcctttga ccagggctcc   5460

tcatctggaa acatatgaga aaggtcagca aacagatgca agacctataa ggctagtcat   5520

tgagctatat tggttttttt tctaaatagt agtagtgaca gataacattt attgagtgct   5580

tgctgtatgc caggcgctga tgtaagcact ttaggtatca ttgaattctc acagcaactc   5640

ctgaggaaag tgctattctt gtctccattt tagtgttgag gaaaacgagg caaagagagg   5700

ttatacaact tgcctcaaat cccttgtgca ctgtaactca cactgagttt cagtgtgatt   5760

tcaggctgtt ggtctccagg gcacaggatc ttagctactc tgggataccc agttctgttt   5820

tcagtatcat ctggcacaca actgtccaag ctctcagccc cacagggaac ctgcccagag   5880

agctttacct ttcccaagca tctgtggcat ggacatgtcc tctgtgcagt ggaaggagga   5940

ggggcgaaag tacgccctta gcctttggag ctagagcacc cttgggaccc ctagttccac   6000

tgcacatggc cctcctcccc accctcatga ctgggaagga agcctgtgat gaggctgaga   6060

taaagcacag ggtggtttca ctctcctctc tccttctttc caaacactga aggatttatt   6120

tcaaactctc taatgcacct gcctcagaga ttcccctact ttcaaagcaa agatcagcag   6180

aaaaattggc tgtcccacct gtggcaaatg ctggagcctc agttaaagtg cctcaagggg   6240

caaatatttc accattgcca gagaagatgt gacaggccaa tcagacaggg cccagagcat   6300

ctctttgctg ctactgtttt gccatccttc tattcatatc tgtgcagaac acggtgtttt   6360

aagcttgagt gaaaggaggg tgaggctgcc gatgccttcc tgcccagaag tggatgatgt   6420

gggagttgac aggccaggga gagggtgaag caggtatcag agtcactcct ctgtaccctc   6480

tccttctgtt tttattttag gcacactatc ttcctctctc ctatctttcc ctcagtctcc   6540

caagttcctc taccttcttt atctttgtct tttacttctt ctttctgtga ccctcctttt   6600

ttggcctcct ctttccccaa gactttcttc ctcctgtttc tcgttgagtt ctccccactg   6660

aatgtgtgta tgtatgtaca cacacacaca cgtgtgcaca cacaatgcac acaactccta   6720

tgactggctc ctacttacat tcaagttaaa aaggctgata tgaacagggc aggggaaaat   6780

cttaggatgg ttgtacaatt gactggagga ttttttcccc ttggaagaca ctattgatct   6840

caacctgctg acttttccta atgcttacct gaaggaaccc atcctggcta gaaagggtga   6900

tggtactgga ccggtattca accttgagtt ttcaagctgc caaacaggtc ttaagggagg   6960

tgcttatatc ccaccaacac tctcccagct cccatgtccc caagacctct ggagtttcct   7020

cttgaatgta catgaaccac tgtaatagca ttagactttt aattgagtgt gcaatcgttt   7080

tccatggagt ttggtccgtt cattattttt tagttaacta cacttcttga tattcaaatg   7140

ttctattaaa aaaactgagt atgaagaaaa acactttact actgcagaag gaagaaagaa   7200

tataatatga ccatcttcag gtataacagt gttgtttaaa agagaattat tgtatgatta   7260

taaaagatga aataattaac tgaataataa aacaaagcta ttagtaagca ttgggtatgt   7320

ggatgttgtg tctttcagta atctgagtga actggttaga ctcatcaggg aacttgttaa   7380

ggttttaaag gttacacttc agattccaga cataatgggc cttatagtca tcattctaac   7440

tgga                                                                7444


<210>  6734
<211>  1294
<212>  PRT
<213>  Homosapiens

<400>  6734

Met Ala Leu Ala Gly Leu Cys Ala Leu Leu Ala Cys Cys Trp Gly Pro 
1               5                   10                  15      


Ala Ala Val Leu Ala Thr Ala Ala Gly Asp Val Asp Pro Ser Lys Glu 
            20                  25                  30          


Leu Glu Cys Lys Leu Lys Ser Ile Thr Val Ser Ala Leu Pro Phe Leu 
        35                  40                  45              


Arg Glu Asn Asp Leu Ser Ile Met His Ser Pro Ser Ala Ser Glu Pro 
    50                  55                  60                  


Lys Leu Leu Phe Ser Val Arg Asn Asp Phe Pro Gly Glu Met Val Val 
65                  70                  75                  80  


Val Asp Asp Leu Glu Asn Thr Glu Leu Pro Tyr Phe Val Leu Glu Ile 
                85                  90                  95      


Ser Gly Asn Thr Glu Asp Ile Pro Leu Val Arg Trp Arg Gln Gln Trp 
            100                 105                 110         


Leu Glu Asn Gly Thr Leu Leu Phe His Ile His His Gln Asp Gly Ala 
        115                 120                 125             


Pro Ser Leu Pro Gly Gln Asp Pro Thr Glu Glu Pro Gln His Glu Ser 
    130                 135                 140                 


Ala Glu Glu Glu Leu Arg Ile Leu His Ile Ser Val Met Gly Gly Met 
145                 150                 155                 160 


Ile Ala Leu Leu Leu Ser Ile Leu Cys Leu Val Met Ile Leu Tyr Thr 
                165                 170                 175     


Arg Arg Arg Trp Cys Lys Arg Arg Arg Val Pro Gln Pro Gln Lys Ser 
            180                 185                 190         


Ala Ser Ala Glu Ala Ala Asn Glu Ile His Tyr Ile Pro Ser Val Leu 
        195                 200                 205             


Ile Gly Gly His Gly Arg Glu Ser Leu Arg Asn Ala Arg Val Gln Gly 
    210                 215                 220                 


His Asn Ser Ser Gly Thr Leu Ser Ile Arg Glu Thr Pro Ile Leu Asp 
225                 230                 235                 240 


Gly Tyr Glu Tyr Asp Ile Thr Asp Leu Arg His His Leu Gln Arg Glu 
                245                 250                 255     


Cys Met Asn Gly Gly Glu Asp Phe Ala Ser Gln Val Thr Arg Thr Leu 
            260                 265                 270         


Asp Ser Leu Gln Gly Cys Asn Glu Lys Ser Gly Met Asp Leu Thr Pro 
        275                 280                 285             


Gly Ser Asp Asn Ala Lys Leu Ser Leu Met Asn Lys Tyr Lys Asp Asn 
    290                 295                 300                 


Ile Ile Ala Thr Ser Pro Val Asp Ser Asn His Gln Gln Ala Thr Leu 
305                 310                 315                 320 


Leu Ser His Thr Ser Ser Ser Gln Arg Lys Arg Ile Asn Asn Lys Ala 
                325                 330                 335     


Arg Ala Gly Ser Ala Phe Leu Asn Pro Glu Gly Asp Ser Gly Thr Glu 
            340                 345                 350         


Ala Glu Asn Asp Pro Gln Leu Thr Phe Tyr Thr Asp Pro Ser Arg Ser 
        355                 360                 365             


Arg Arg Arg Ser Arg Val Gly Ser Pro Arg Ser Pro Val Asn Lys Thr 
    370                 375                 380                 


Thr Leu Thr Leu Ile Ser Ile Thr Ser Cys Val Ile Gly Leu Val Cys 
385                 390                 395                 400 


Ser Ser His Val Asn Cys Pro Leu Val Val Lys Ile Thr Leu His Val 
                405                 410                 415     


Pro Glu His Leu Ile Ala Asp Gly Ser Arg Phe Ile Leu Leu Glu Gly 
            420                 425                 430         


Ser Gln Leu Asp Ala Ser Asp Trp Leu Asn Pro Ala Gln Val Val Leu 
        435                 440                 445             


Phe Ser Gln Gln Asn Ser Ser Gly Pro Trp Ala Met Asp Leu Cys Ala 
    450                 455                 460                 


Arg Arg Leu Leu Asp Pro Cys Glu His Gln Cys Asp Pro Glu Thr Gly 
465                 470                 475                 480 


Glu Cys Leu Cys Tyr Glu Gly Tyr Met Lys Asp Pro Val His Lys His 
                485                 490                 495     


Leu Cys Ile Arg Asn Glu Trp Gly Thr Asn Gln Gly Pro Trp Pro Tyr 
            500                 505                 510         


Thr Ile Phe Gln Arg Gly Phe Asp Leu Val Leu Gly Glu Gln Pro Ser 
        515                 520                 525             


Asp Lys Ile Phe Arg Phe Thr Tyr Thr Leu Gly Glu Gly Met Trp Leu 
    530                 535                 540                 


Pro Leu Ser Lys Ser Phe Val Ile Pro Pro Ala Glu Leu Ala Ile Asn 
545                 550                 555                 560 


Pro Ser Ala Lys Cys Lys Thr Asp Met Thr Val Met Glu Asp Ala Val 
                565                 570                 575     


Glu Val Arg Glu Glu Leu Met Thr Ser Ser Ser Phe Asp Ser Leu Glu 
            580                 585                 590         


Val Leu Leu Asp Ser Phe Gly Pro Val Arg Asp Cys Ser Lys Asp Asn 
        595                 600                 605             


Gly Gly Cys Ser Lys Asn Phe Arg Cys Ile Ser Asp Arg Lys Leu Asp 
    610                 615                 620                 


Ser Thr Gly Cys Val Cys Pro Ser Gly Leu Ser Pro Met Lys Asp Ser 
625                 630                 635                 640 


Ser Gly Cys Tyr Asp Arg His Ile Gly Val Asp Cys Ser Asp Gly Phe 
                645                 650                 655     


Asn Gly Gly Cys Glu Gln Leu Cys Leu Gln Gln Met Ala Pro Phe Pro 
            660                 665                 670         


Asp Asp Pro Thr Leu Tyr Asn Ile Leu Met Phe Cys Gly Cys Ile Glu 
        675                 680                 685             


Asp Tyr Lys Leu Gly Val Asp Gly Arg Ser Cys Gln Leu Ile Thr Glu 
    690                 695                 700                 


Thr Cys Pro Glu Gly Ser Asp Cys Gly Glu Ser Arg Glu Leu Pro Met 
705                 710                 715                 720 


Asn Gln Thr Leu Phe Gly Glu Met Phe Phe Gly Tyr Asn Asn His Ser 
                725                 730                 735     


Lys Glu Val Ala Ala Gly Gln Val Leu Lys Gly Thr Phe Arg Gln Asn 
            740                 745                 750         


Asn Phe Ala Arg Gly Leu Asp Gln Gln Leu Pro Asp Gly Leu Val Val 
        755                 760                 765             


Ala Thr Val Pro Leu Glu Asn Gln Cys Leu Glu Glu Ile Ser Glu Pro 
    770                 775                 780                 


Thr Pro Asp Pro Asp Phe Leu Thr Gly Met Val Asn Phe Ser Glu Val 
785                 790                 795                 800 


Ser Gly Tyr Pro Val Leu Gln His Trp Lys Val Arg Ser Val Met Tyr 
                805                 810                 815     


His Ile Lys Leu Asn Gln Val Ala Ile Ser Gln Ala Leu Ser Asn Ala 
            820                 825                 830         


Leu His Ser Leu Asp Gly Ala Thr Ser Arg Ala Asp Phe Val Ala Leu 
        835                 840                 845             


Leu Asp Gln Phe Gly Asn His Tyr Ile Gln Glu Ala Ile Tyr Gly Phe 
    850                 855                 860                 


Glu Glu Ser Cys Ser Ile Trp Tyr Pro Asn Lys Gln Val Gln Arg Arg 
865                 870                 875                 880 


Leu Trp Leu Glu Tyr Glu Asp Ile Ser Lys Gly Asn Ser Pro Ser Asp 
                885                 890                 895     


Glu Ser Glu Glu Arg Glu Arg Asp Pro Lys Val Leu Thr Phe Pro Glu 
            900                 905                 910         


Tyr Ile Thr Ser Leu Ser Asp Ser Gly Thr Lys His Met Ala Ala Gly 
        915                 920                 925             


Val Arg Met Glu Cys His Ser Lys Gly Arg Cys Pro Ser Ser Cys Pro 
    930                 935                 940                 


Leu Cys His Val Thr Ser Ser Pro Asp Thr Pro Ala Glu Pro Val Leu 
945                 950                 955                 960 


Leu Glu Val Thr Lys Ala Ala Pro Ile Tyr Glu Leu Val Thr Asn Asn 
                965                 970                 975     


Gln Thr Gln Arg Leu Leu Gln Glu Ala Thr Met Ser Ser Leu Trp Cys 
            980                 985                 990         


Ser Gly Thr Gly Asp Val Ile Glu  Asp Trp Cys Arg Cys  Asp Ser Thr 
        995                 1000                 1005             


Ala Phe  Gly Ala Asp Gly Leu  Pro Thr Cys Ala Pro  Leu Pro Gln 
    1010                 1015                 1020             


Pro Val  Leu Arg Leu Ser Thr  Val His Glu Pro Ser  Ser Thr Leu 
    1025                 1030                 1035             


Val Val  Leu Glu Trp Glu His  Ser Glu Pro Pro Ile  Gly Val Gln 
    1040                 1045                 1050             


Ile Val  Asp Tyr Leu Leu Arg  Gln Glu Lys Val Thr  Asp Arg Met 
    1055                 1060                 1065             


Asp His  Ser Lys Val Glu Thr  Glu Thr Val Leu Ser  Phe Val Asp 
    1070                 1075                 1080             


Asp Ile  Ile Ser Gly Ala Lys  Ser Pro Cys Ala Met  Pro Ser Gln 
    1085                 1090                 1095             


Val Pro  Asp Lys Gln Leu Thr  Thr Ile Ser Leu Ile  Ile Arg Cys 
    1100                 1105                 1110             


Leu Glu  Pro Asp Thr Ile Tyr  Met Phe Thr Leu Trp  Gly Val Asp 
    1115                 1120                 1125             


Asn Thr  Gly Arg Arg Ser Arg  Pro Ser Asp Val Ile  Val Lys Thr 
    1130                 1135                 1140             


Pro Cys  Pro Val Val Asp Asp  Val Lys Ala Gln Glu  Ile Ala Asp 
    1145                 1150                 1155             


Lys Ile  Tyr Asn Leu Phe Asn  Gly Tyr Thr Ser Gly  Lys Glu Gln 
    1160                 1165                 1170             


Gln Thr  Ala Tyr Asn Thr Leu  Leu Asp Leu Gly Ser  Pro Thr Leu 
    1175                 1180                 1185             


His Arg  Val Leu Tyr His Tyr  Asn Gln His Tyr Glu  Ser Phe Gly 
    1190                 1195                 1200             


Glu Phe  Thr Trp Arg Cys Glu  Asp Glu Leu Gly Pro  Arg Lys Ala 
    1205                 1210                 1215             


Gly Leu  Ile Leu Ser Gln Leu  Gly Asp Leu Ser Ser  Trp Cys Asn 
    1220                 1225                 1230             


Gly Leu  Leu Gln Glu Pro Lys  Ile Ser Leu Arg Arg  Ser Ser Leu 
    1235                 1240                 1245             


Lys Tyr  Leu Gly Cys Arg Tyr  Ser Glu Ile Lys Pro  Tyr Gly Leu 
    1250                 1255                 1260             


Asp Trp  Ala Glu Leu Ser Arg  Asp Leu Arg Lys Thr  Cys Glu Glu 
    1265                 1270                 1275             


Gln Thr  Leu Ser Ile Pro Tyr  Asn Asp Tyr Gly Asp  Ser Lys Glu 
    1280                 1285                 1290             


Ile 
    


<210>  6735
<211>  7317
<212>  DNA
<213>  Homosapiens

<400>  6735
gctccgggaa acaaagaatc cggggctctc cagacatcag agcttaaacc caggactctg     60

caagcggcat ctcattccgg ggtccagggc tctcccggct ctccatcccc tccctaacct    120

cccccgcctc ccgcgctcgc tccctcgctc cctccccgct cgcttcctcc cccaccatcg    180

cagcgctagg aggaaggcgg ccggggctca agatggcttt agccgggctc tgcgccctgc    240

tcgcctgctg ctgggggccg gcggcggtgc tggccacggc cgccggcgac gtggatccat    300

ccaaggagct ggagtgcaag ctcaaaagca tcacggtgtc ggcactgccc ttcctgcgcg    360

agaacgacct gagcatcatg cacagcccct cggcctcgga gcccaagctc ctcttctcgg    420

tgcgcaacga cttcccggga gaaatggtcg tggtggacga cctggagaac acggagctgc    480

cctacttcgt gctggagatc tcagggaaca cagaggatat ccctttggtg cgctggaggc    540

agcagtggct ggagaatggc actttgcttt ttcacattca tcaccaagat ggtgccccaa    600

gccttcctgg acaagacccc actgaagaac cccaacatga gtcggcagaa gaggagctga    660

ggatcctcca catctcagtc atgggtggca tgatcgctct gctgctgtcc atcttgtgcc    720

tggtgatgat cctgtatact cgccggcgct ggtgcaaacg ccgccgggtc ccgcagcccc    780

agaagagtgc cagtgctgag gcagccaatg agattcacta cattccttct gtgctgatcg    840

gcgggcacgg acgggagagc ctgcgcaatg cccgcgtgca gggccacaac tccagtggca    900

ccctgagcat ccgggagaca cctatcctgg acggctatga gtatgacatc actgatctgc    960

gccaccatct gcagagggag tgcatgaacg gaggggagga ctttgccagc caggtcacgc   1020

gcaccctcga ctccctgcag ggctgcaatg aaaagtcggg gatggacctc acaccaggaa   1080

gtgacaatgc caagctgtca ctgatgaaca agtataaaga taatattata gccactagcc   1140

ctgtggactc caaccaccag caagccaccc ttctctctca cacctccagc agccagagaa   1200

agcggatcaa caacaaagca agagctggtt ccgccttctt gaaccctgaa ggggattctg   1260

gcacagaggc agaaaacgac ccccagctga ccttttacac ggatccttca aggagcagga   1320

ggcgtagtag agtgggttct ccccgaagtc ctgtgaataa gaccaccttg accctgatca   1380

gcatcaccag ctgtgtgatt ggcctcgtgt gctcctctca cgtcaactgc cctctcgttg   1440

tcaagatcac cctgcatgtc cctgagcacc tgattgctga tgggagccgc ttcatcttgc   1500

tggaggggag ccagctggat gccagtgact ggctgaaccc tgcccaagtg gttctcttct   1560

ctcagcagaa ctccagcgga ccctgggcca tggacctctg tgcccggcgg ctcctggacc   1620

cctgtgaaca ccaatgtgac cccgaaactg gggaatgcct ctgctatgaa ggctacatga   1680

aggatccagt acataagcac ctttgcattc ggaacgaatg ggggacaaac caggggccat   1740

ggccttacac aatatttcag cgaggctttg acctggtttt gggagagcag ccctctgata   1800

aaatatttag attcacctac actcttgggg agggcatgtg gttgcccctc agcaagagct   1860

ttgtgattcc accagccgaa ctggccatca atccatcagc aaagtgcaag acggacatga   1920

ctgtgatgga ggatgctgtg gaggtcagag aggagctgat gacttcatcc tccttcgaca   1980

gcctggaggt tctcttagat tcctttgggc cggtgcgcga ctgcagcaaa gataacgggg   2040

gctgcagtaa gaatttccgc tgtatttcag atcgcaagct ggactccact ggttgcgtgt   2100

gcccatctgg actcagtccc atgaaggaca gctctggctg ctatgaccgc cacatcgggg   2160

tggactgttc cgacggcttc aacggcggct gtgagcagct gtgcctccag cagatggcgc   2220

ccttcccgga cgaccccacc ttgtataaca tcctcatgtt ctgtgggtgc atcgaggact   2280

acaagcttgg tgtggatgga cgctcttgcc aactcatcac ggagacctgt ccagagggaa   2340

gtgactgtgg ggaaagcagg gagcttccca tgaaccagac cctctttggg gagatgttct   2400

ttggttacaa caaccattcc aaggaagtgg ctgccggaca ggtgctgaaa ggaacattca   2460

ggcaaaacaa ctttgctcgt ggtttagacc agcaactgcc agatggtctt gtggtggcca   2520

ctgtgcccct ggagaatcaa tgcctagagg agatctcgga gcccacccct gaccctgact   2580

tcctgactgg gatggtgaac ttcagtgaag tgtctgggta ccctgtgctg cagcactgga   2640

aggtccggtc tgtgatgtac cacatcaaac tcaaccaagt ggccatctct caggccctca   2700

gcaatgctct ccactcgctg gatggggcta catctcgtgc agattttgtg gcgctgttgg   2760

accagttcgg caaccattac atccaggaag ctatctacgg ctttgaggag tcctgttcta   2820

tctggtaccc aaacaagcag gtccagcggc gactctggct ggagtatgaa gacatcagta   2880

aaggcaactc cccatcagat gagtctgagg agcgggaaag agaccccaag gtgctgacat   2940

tcccagaata catcaccagc ttgtcagact ccggcaccaa gcacatggcg gctggagtcc   3000

gcatggagtg ccacagcaag ggacgatgcc cctcgtcctg ccccctgtgt catgtgacat   3060

ccagccctga cacccctgct gagccggttc tgctggaggt gaccaaagca gcccccatct   3120

atgaactagt gaccaacaac cagacccaga ggctcttgca ggaggctacc atgagctctc   3180

tctggtgctc agggactgga gatgtcatcg aggactggtg tcgatgtgac tccactgctt   3240

ttggagctga tggactcccc acctgtgcgc ctctcccaca gcctgtgctg agactctcca   3300

cggttcacga gcccagcagc actcttgtgg tcctggagtg ggaacactca gagccaccaa   3360

tcggggtgca gattgtagat tacctcctcc gtcaagagaa agtcactgac aggatggacc   3420

actccaaagt ggagacagaa acagtgctga gctttgtgga cgacatcatc tctggagcaa   3480

agtctccttg tgcaatgcca tctcaggtgc cggacaagca gctcaccacc atctctctga   3540

tcatacgatg cctggaacct gacaccattt acatgttcac gctgtgggga gtggacaaca   3600

caggacggcg ctccaggcca agcgacgtga tcgtgaagac cccatgcccc gtggtggatg   3660

atgtcaaggc tcaagaaata gcagacaaga tctacaatct cttcaatggc tacactagtg   3720

ggaaggagca gcagaccgcc tacaacaccc tcctggatct gggttccccc accttacacc   3780

gggtcctcta ccactataac cagcactatg agagttttgg ggaattcacc tggcgatgtg   3840

aggatgagtt aggtcccagg aaagctggtc tcatcctttc ccagcttggg gacctcagca   3900

gttggtgcaa tggactcctt caggaaccca agataagctt gcggcgcagc tcactcaagt   3960

acctggggtg ccgctacagc gagatcaaac cctacggact tgactgggcg gagctcagcc   4020

gggacctcag gaagacgtgt gaggagcaga ccctgagtat cccctacaac gactatgggg   4080

acagcaaaga gatctagcac cataaggcca gggagctgct gccagaatga agtaggaaag   4140

aggagggatc catctgggtt ggtctgtgga tttttaatat tttttaatgg aacatgaaaa   4200

cctccacagc aacatcgaaa ccagggagaa agtgatcctt gctccctgca gaacttcttc   4260

agtatgatgt tctccatctg catgattggg aaatctgcca gccagtggct tcatgcagtg   4320

ccatatttct ttagaggatt actttggggt ttgctttgcc attaatttgt tccattcatt   4380

tttttttccc tgagaagttt accaaaatgc tcaagagctc tgccgtgctc cccatgaaaa   4440

gtctattaag taggcaccct gtgctcactc agttcctaaa tccattgcaa ctgggagcag   4500

aggtgaggcc agaaagttgt taggcctgcc gcaggcccca ccctcaagca ttcctcagga   4560

agcgtctcac tctgggagcc ttggccctgc tcacagagag agacaataga aaattgagga   4620

aggtggccct tgtctgtgtc tcctggtttt cttcctaggc cttgctatca ctatttccat   4680

acccgaaagg tgaaaccagc tttcattata ggccccagtg ggccacttgg gttttgagat   4740

ccttccttat tttaagccag gactgggatt aaatctccct ctgtcagatc tctgtccctt   4800

cctctgaaca acatgatctt tgagagggaa caagatgcca tctgtcaact gcaccttcag   4860

aaaagtctac ctgggagact agttagcagt ccacattcaa gaggagactt ggagtttatt   4920

gttttttaaa aaaaccatgc ttcctttgga tagacttctc cagcctacca atatatatcc   4980

atgtgcctgg attatcttta acccccacac ctcttacctt ggacaggtaa ggcttggccg   5040

atgtctgatt gggaccagga ggggtcaaca ctttcatatc agtgttacag tgaactaaag   5100

ctattattga tcacaaaaaa cttctgttca tccccacctt gctaaatttg cttgtgttgc   5160

tagttttgca aatcgtttct ctgatgacca taagcaggag gattccacca tggtcactgc   5220

ccatccagtc acagggattc tgtgtaggga agcaccactg attgcagtta acatctagag   5280

tgttgtttcc atcccactgc ccaagcattg gcatggtcat gaatggtggc ccagccaaca   5340

ggaagcccag cctttcagaa agagcctggc aaggccctgt tgactagcaa tggccttagc   5400

tgtcccacac aactcagtgg cctgaacaca caccttcagc caccatgcct ttgaccaggg   5460

ctcctcatct ggaaacatat gagaaaggtc agcaaacaga tgcaagacct ataaggctag   5520

tcattgagct atattggttt tttttctaaa tagtagtagt gacagataac atttattgag   5580

tgcttgctgt atgccaggcg ctgatgtaag cactttaggt atcattgaat tctcacagca   5640

actcctgagg aaagtgctat tcttgtctcc attttagtgt tgaggaaaac gaggcaaaga   5700

gaggttatac aacttgcctc aaatcccttg tgcactgtaa ctcacactga gtttcagtgt   5760

gatttcaggc tgttggtctc cagggcacag gatcttagct actctgggat acccagttct   5820

gttttcagta tcatctggca cacaactgtc caagctctca gccccacagg gaacctgccc   5880

agagagcttt acctttccca agcatctgtg gcatggacat gtcctctgtg cagtggaagg   5940

aggaggggcg aaagtacgcc cttagccttt ggagctagag cacccttggg acccctagtt   6000

ccactgcaca tggccctcct ccccaccctc atgactggga aggaagcctg tgatgaggct   6060

gagataaagc acagggtggt ttcactctcc tctctccttc tttccaaaca ctgaaggatt   6120

tatttcaaac tctctaatgc acctgcctca gagattcccc tactttcaaa gcaaagatca   6180

gcagaaaaat tggctgtccc acctgtggca aatgctggag cctcagttaa agtgcctcaa   6240

ggggcaaata tttcaccatt gccagagaag atgtgacagg ccaatcagac agggcccaga   6300

gcatctcttt gctgctactg ttttgccatc cttctattca tatctgtgca gaacacggtg   6360

ttttaagctt gagtgaaagg agggtgaggc tgccgatgcc ttcctgccca gaagtggatg   6420

atgtgggagt tgacaggcca gggagagggt gaagcaggta tcagagtcac tcctctgtac   6480

cctctccttc tgtttttatt ttaggcacac tatcttcctc tctcctatct ttccctcagt   6540

ctcccaagtt cctctacctt ctttatcttt gtcttttact tcttctttct gtgaccctcc   6600

ttttttggcc tcctctttcc ccaagacttt cttcctcctg tttctcgttg agttctcccc   6660

actgaatgtg tgtatgtatg tacacacaca cacacgtgtg cacacacaat gcacacaact   6720

cctatgactg gctcctactt acattcaagt taaaaaggct gatatgaaca gggcagggga   6780

aaatcttagg atggttgtac aattgactgg aggatttttt ccccttggaa gacactattg   6840

atctcaacct gctgactttt cctaatgctt acctgaagga acccatcctg gctagaaagg   6900

gtgatggtac tggaccggta ttcaaccttg agttttcaag ctgccaaaca ggtcttaagg   6960

gaggtgctta tatcccacca acactctccc agctcccatg tccccaagac ctctggagtt   7020

tcctcttgaa tgtacatgaa ccactgtaat agcattagac ttttaattga gtgtgcaatc   7080

gttttccatg gagtttggtc cgttcattat tttttagtta actacacttc ttgatattca   7140

aatgttctat taaaaaaact gagtatgaag aaaaacactt tactactgca gaaggaagaa   7200

agaatataat atgaccatct tcaggtataa cagtgttgtt taaaagagaa ttattgtatg   7260

attataaaag atgaaataat taactgaata ataaaacaaa gctattagta agcattg      7317


<210>  6736
<211>  1294
<212>  PRT
<213>  Homosapiens

<400>  6736

Met Ala Leu Ala Gly Leu Cys Ala Leu Leu Ala Cys Cys Trp Gly Pro 
1               5                   10                  15      


Ala Ala Val Leu Ala Thr Ala Ala Gly Asp Val Asp Pro Ser Lys Glu 
            20                  25                  30          


Leu Glu Cys Lys Leu Lys Ser Ile Thr Val Ser Ala Leu Pro Phe Leu 
        35                  40                  45              


Arg Glu Asn Asp Leu Ser Ile Met His Ser Pro Ser Ala Ser Glu Pro 
    50                  55                  60                  


Lys Leu Leu Phe Ser Val Arg Asn Asp Phe Pro Gly Glu Met Val Val 
65                  70                  75                  80  


Val Asp Asp Leu Glu Asn Thr Glu Leu Pro Tyr Phe Val Leu Glu Ile 
                85                  90                  95      


Ser Gly Asn Thr Glu Asp Ile Pro Leu Val Arg Trp Arg Gln Gln Trp 
            100                 105                 110         


Leu Glu Asn Gly Thr Leu Leu Phe His Ile His His Gln Asp Gly Ala 
        115                 120                 125             


Pro Ser Leu Pro Gly Gln Asp Pro Thr Glu Glu Pro Gln His Glu Ser 
    130                 135                 140                 


Ala Glu Glu Glu Leu Arg Ile Leu His Ile Ser Val Met Gly Gly Met 
145                 150                 155                 160 


Ile Ala Leu Leu Leu Ser Ile Leu Cys Leu Val Met Ile Leu Tyr Thr 
                165                 170                 175     


Arg Arg Arg Trp Cys Lys Arg Arg Arg Val Pro Gln Pro Gln Lys Ser 
            180                 185                 190         


Ala Ser Ala Glu Ala Ala Asn Glu Ile His Tyr Ile Pro Ser Val Leu 
        195                 200                 205             


Ile Gly Gly His Gly Arg Glu Ser Leu Arg Asn Ala Arg Val Gln Gly 
    210                 215                 220                 


His Asn Ser Ser Gly Thr Leu Ser Ile Arg Glu Thr Pro Ile Leu Asp 
225                 230                 235                 240 


Gly Tyr Glu Tyr Asp Ile Thr Asp Leu Arg His His Leu Gln Arg Glu 
                245                 250                 255     


Cys Met Asn Gly Gly Glu Asp Phe Ala Ser Gln Val Thr Arg Thr Leu 
            260                 265                 270         


Asp Ser Leu Gln Gly Cys Asn Glu Lys Ser Gly Met Asp Leu Thr Pro 
        275                 280                 285             


Gly Ser Asp Asn Ala Lys Leu Ser Leu Met Asn Lys Tyr Lys Asp Asn 
    290                 295                 300                 


Ile Ile Ala Thr Ser Pro Val Asp Ser Asn His Gln Gln Ala Thr Leu 
305                 310                 315                 320 


Leu Ser His Thr Ser Ser Ser Gln Arg Lys Arg Ile Asn Asn Lys Ala 
                325                 330                 335     


Arg Ala Gly Ser Ala Phe Leu Asn Pro Glu Gly Asp Ser Gly Thr Glu 
            340                 345                 350         


Ala Glu Asn Asp Pro Gln Leu Thr Phe Tyr Thr Asp Pro Ser Arg Ser 
        355                 360                 365             


Arg Arg Arg Ser Arg Val Gly Ser Pro Arg Ser Pro Val Asn Lys Thr 
    370                 375                 380                 


Thr Leu Thr Leu Ile Ser Ile Thr Ser Cys Val Ile Gly Leu Val Cys 
385                 390                 395                 400 


Ser Ser His Val Asn Cys Pro Leu Val Val Lys Ile Thr Leu His Val 
                405                 410                 415     


Pro Glu His Leu Ile Ala Asp Gly Ser Arg Phe Ile Leu Leu Glu Gly 
            420                 425                 430         


Ser Gln Leu Asp Ala Ser Asp Trp Leu Asn Pro Ala Gln Val Val Leu 
        435                 440                 445             


Phe Ser Gln Gln Asn Ser Ser Gly Pro Trp Ala Met Asp Leu Cys Ala 
    450                 455                 460                 


Arg Arg Leu Leu Asp Pro Cys Glu His Gln Cys Asp Pro Glu Thr Gly 
465                 470                 475                 480 


Glu Cys Leu Cys Tyr Glu Gly Tyr Met Lys Asp Pro Val His Lys His 
                485                 490                 495     


Leu Cys Ile Arg Asn Glu Trp Gly Thr Asn Gln Gly Pro Trp Pro Tyr 
            500                 505                 510         


Thr Ile Phe Gln Arg Gly Phe Asp Leu Val Leu Gly Glu Gln Pro Ser 
        515                 520                 525             


Asp Lys Ile Phe Arg Phe Thr Tyr Thr Leu Gly Glu Gly Met Trp Leu 
    530                 535                 540                 


Pro Leu Ser Lys Ser Phe Val Ile Pro Pro Ala Glu Leu Ala Ile Asn 
545                 550                 555                 560 


Pro Ser Ala Lys Cys Lys Thr Asp Met Thr Val Met Glu Asp Ala Val 
                565                 570                 575     


Glu Val Arg Glu Glu Leu Met Thr Ser Ser Ser Phe Asp Ser Leu Glu 
            580                 585                 590         


Val Leu Leu Asp Ser Phe Gly Pro Val Arg Asp Cys Ser Lys Asp Asn 
        595                 600                 605             


Gly Gly Cys Ser Lys Asn Phe Arg Cys Ile Ser Asp Arg Lys Leu Asp 
    610                 615                 620                 


Ser Thr Gly Cys Val Cys Pro Ser Gly Leu Ser Pro Met Lys Asp Ser 
625                 630                 635                 640 


Ser Gly Cys Tyr Asp Arg His Ile Gly Val Asp Cys Ser Asp Gly Phe 
                645                 650                 655     


Asn Gly Gly Cys Glu Gln Leu Cys Leu Gln Gln Met Ala Pro Phe Pro 
            660                 665                 670         


Asp Asp Pro Thr Leu Tyr Asn Ile Leu Met Phe Cys Gly Cys Ile Glu 
        675                 680                 685             


Asp Tyr Lys Leu Gly Val Asp Gly Arg Ser Cys Gln Leu Ile Thr Glu 
    690                 695                 700                 


Thr Cys Pro Glu Gly Ser Asp Cys Gly Glu Ser Arg Glu Leu Pro Met 
705                 710                 715                 720 


Asn Gln Thr Leu Phe Gly Glu Met Phe Phe Gly Tyr Asn Asn His Ser 
                725                 730                 735     


Lys Glu Val Ala Ala Gly Gln Val Leu Lys Gly Thr Phe Arg Gln Asn 
            740                 745                 750         


Asn Phe Ala Arg Gly Leu Asp Gln Gln Leu Pro Asp Gly Leu Val Val 
        755                 760                 765             


Ala Thr Val Pro Leu Glu Asn Gln Cys Leu Glu Glu Ile Ser Glu Pro 
    770                 775                 780                 


Thr Pro Asp Pro Asp Phe Leu Thr Gly Met Val Asn Phe Ser Glu Val 
785                 790                 795                 800 


Ser Gly Tyr Pro Val Leu Gln His Trp Lys Val Arg Ser Val Met Tyr 
                805                 810                 815     


His Ile Lys Leu Asn Gln Val Ala Ile Ser Gln Ala Leu Ser Asn Ala 
            820                 825                 830         


Leu His Ser Leu Asp Gly Ala Thr Ser Arg Ala Asp Phe Val Ala Leu 
        835                 840                 845             


Leu Asp Gln Phe Gly Asn His Tyr Ile Gln Glu Ala Ile Tyr Gly Phe 
    850                 855                 860                 


Glu Glu Ser Cys Ser Ile Trp Tyr Pro Asn Lys Gln Val Gln Arg Arg 
865                 870                 875                 880 


Leu Trp Leu Glu Tyr Glu Asp Ile Ser Lys Gly Asn Ser Pro Ser Asp 
                885                 890                 895     


Glu Ser Glu Glu Arg Glu Arg Asp Pro Lys Val Leu Thr Phe Pro Glu 
            900                 905                 910         


Tyr Ile Thr Ser Leu Ser Asp Ser Gly Thr Lys His Met Ala Ala Gly 
        915                 920                 925             


Val Arg Met Glu Cys His Ser Lys Gly Arg Cys Pro Ser Ser Cys Pro 
    930                 935                 940                 


Leu Cys His Val Thr Ser Ser Pro Asp Thr Pro Ala Glu Pro Val Leu 
945                 950                 955                 960 


Leu Glu Val Thr Lys Ala Ala Pro Ile Tyr Glu Leu Val Thr Asn Asn 
                965                 970                 975     


Gln Thr Gln Arg Leu Leu Gln Glu Ala Thr Met Ser Ser Leu Trp Cys 
            980                 985                 990         


Ser Gly Thr Gly Asp Val Ile Glu  Asp Trp Cys Arg Cys  Asp Ser Thr 
        995                 1000                 1005             


Ala Phe  Gly Ala Asp Gly Leu  Pro Thr Cys Ala Pro  Leu Pro Gln 
    1010                 1015                 1020             


Pro Val  Leu Arg Leu Ser Thr  Val His Glu Pro Ser  Ser Thr Leu 
    1025                 1030                 1035             


Val Val  Leu Glu Trp Glu His  Ser Glu Pro Pro Ile  Gly Val Gln 
    1040                 1045                 1050             


Ile Val  Asp Tyr Leu Leu Arg  Gln Glu Lys Val Thr  Asp Arg Met 
    1055                 1060                 1065             


Asp His  Ser Lys Val Glu Thr  Glu Thr Val Leu Ser  Phe Val Asp 
    1070                 1075                 1080             


Asp Ile  Ile Ser Gly Ala Lys  Ser Pro Cys Ala Met  Pro Ser Gln 
    1085                 1090                 1095             


Val Pro  Asp Lys Gln Leu Thr  Thr Ile Ser Leu Ile  Ile Arg Cys 
    1100                 1105                 1110             


Leu Glu  Pro Asp Thr Ile Tyr  Met Phe Thr Leu Trp  Gly Val Asp 
    1115                 1120                 1125             


Asn Thr  Gly Arg Arg Ser Arg  Pro Ser Asp Val Ile  Val Lys Thr 
    1130                 1135                 1140             


Pro Cys  Pro Val Val Asp Asp  Val Lys Ala Gln Glu  Ile Ala Asp 
    1145                 1150                 1155             


Lys Ile  Tyr Asn Leu Phe Asn  Gly Tyr Thr Ser Gly  Lys Glu Gln 
    1160                 1165                 1170             


Gln Thr  Ala Tyr Asn Thr Leu  Leu Asp Leu Gly Ser  Pro Thr Leu 
    1175                 1180                 1185             


His Arg  Val Leu Tyr His Tyr  Asn Gln His Tyr Glu  Ser Phe Gly 
    1190                 1195                 1200             


Glu Phe  Thr Trp Arg Cys Glu  Asp Glu Leu Gly Pro  Arg Lys Ala 
    1205                 1210                 1215             


Gly Leu  Ile Leu Ser Gln Leu  Gly Asp Leu Ser Ser  Trp Cys Asn 
    1220                 1225                 1230             


Gly Leu  Leu Gln Glu Pro Lys  Ile Ser Leu Arg Arg  Ser Ser Leu 
    1235                 1240                 1245             


Lys Tyr  Leu Gly Cys Arg Tyr  Ser Glu Ile Lys Pro  Tyr Gly Leu 
    1250                 1255                 1260             


Asp Trp  Ala Glu Leu Ser Arg  Asp Leu Arg Lys Thr  Cys Glu Glu 
    1265                 1270                 1275             


Gln Thr  Leu Ser Ile Pro Tyr  Asn Asp Tyr Gly Asp  Ser Lys Glu 
    1280                 1285                 1290             


Ile 
    


<210>  6737
<211>  7313
<212>  DNA
<213>  Homosapiens

<400>  6737
ggggtctcta gtgacccgag gcttccggag gaggctgccc ttgctccgcg gtccctcgcg     60

gctcaaatcc gaaaggtcgg agatttcaga aagaagaggc gtgtgcaggg cgcctcccaa    120

gaccccgcca gccgccggca cacccagcat ctttgaagtg gggcttcggc actgggccgg    180

ggcgcacgcg gggcggccgg ggctcaagat ggctttagcc gggctctgcg ccctgctcgc    240

ctgctgctgg gggccggcgg cggtgctggc cacggccgcc ggcgacgtgg atccatccaa    300

ggagctggag tgcaagctca aaagcatcac ggtgtcggca ctgcccttcc tgcgcgagaa    360

cgacctgagc atcatgcaca gcccctcggc ctcggagccc aagctcctct tctcggtgcg    420

caacgacttc ccgggagaaa tggtcgtggt ggacgacctg gagaacacgg agctgcccta    480

cttcgtgctg gagatctcag ggaacacaga ggatatccct ttggtgcgct ggaggcagca    540

gtggctggag aatggcactt tgctttttca cattcatcac caagatggtg ccccaagcct    600

tcctggacaa gaccccactg aagaacccca acatgagtcg gcagaagagg agctgaggat    660

cctccacatc tcagtcatgg gtggcatgat cgctctgctg ctgtccatct tgtgcctggt    720

gatgatcctg tatactcgcc ggcgctggtg caaacgccgc cgggtcccgc agccccagaa    780

gagtgccagt gctgaggcag ccaatgagat tcactacatt ccttctgtgc tgatcggcgg    840

gcacggacgg gagagcctgc gcaatgcccg cgtgcagggc cacaactcca gtggcaccct    900

gagcatccgg gagacaccta tcctggacgg ctatgagtat gacatcactg atctgcgcca    960

ccatctgcag agggagtgca tgaacggagg ggaggacttt gccagccagg tcacgcgcac   1020

cctcgactcc ctgcagggct gcaatgaaaa gtcggggatg gacctcacac caggaagtga   1080

caatgccaag ctgtcactga tgaacaagta taaagataat attatagcca ctagccctgt   1140

ggactccaac caccagcaag ccacccttct ctctcacacc tccagcagcc agagaaagcg   1200

gatcaacaac aaagcaagag ctggttccgc cttcttgaac cctgaagggg attctggcac   1260

agaggcagaa aacgaccccc agctgacctt ttacacggat ccttcaagga gcaggaggcg   1320

tagtagagtg ggttctcccc gaagtcctgt gaataagacc accttgaccc tgatcagcat   1380

caccagctgt gtgattggcc tcgtgtgctc ctctcacgtc aactgccctc tcgttgtcaa   1440

gatcaccctg catgtccctg agcacctgat tgctgatggg agccgcttca tcttgctgga   1500

ggggagccag ctggatgcca gtgactggct gaaccctgcc caagtggttc tcttctctca   1560

gcagaactcc agcggaccct gggccatgga cctctgtgcc cggcggctcc tggacccctg   1620

tgaacaccaa tgtgaccccg aaactgggga atgcctctgc tatgaaggct acatgaagga   1680

tccagtacat aagcaccttt gcattcggaa cgaatggggg acaaaccagg ggccatggcc   1740

ttacacaata tttcagcgag gctttgacct ggttttggga gagcagccct ctgataaaat   1800

atttagattc acctacactc ttggggaggg catgtggttg cccctcagca agagctttgt   1860

gattccacca gccgaactgg ccatcaatcc atcagcaaag tgcaagacgg acatgactgt   1920

gatggaggat gctgtggagg tcagagagga gctgatgact tcatcctcct tcgacagcct   1980

ggaggttctc ttagattcct ttgggccggt gcgcgactgc agcaaagata acgggggctg   2040

cagtaagaat ttccgctgta tttcagatcg caagctggac tccactggtt gcgtgtgccc   2100

atctggactc agtcccatga aggacagctc tggctgctat gaccgccaca tcggggtgga   2160

ctgttccgac ggcttcaacg gcggctgtga gcagctgtgc ctccagcaga tggcgccctt   2220

cccggacgac cccaccttgt ataacatcct catgttctgt gggtgcatcg aggactacaa   2280

gcttggtgtg gatggacgct cttgccaact catcacggag acctgtccag agggaagtga   2340

ctgtggggaa agcagggagc ttcccatgaa ccagaccctc tttggggaga tgttctttgg   2400

ttacaacaac cattccaagg aagtggctgc cggacaggtg ctgaaaggaa cattcaggca   2460

aaacaacttt gctcgtggtt tagaccagca actgccagat ggtcttgtgg tggccactgt   2520

gcccctggag aatcaatgcc tagaggagat ctcggagccc acccctgacc ctgacttcct   2580

gactgggatg gtgaacttca gtgaagtgtc tgggtaccct gtgctgcagc actggaaggt   2640

ccggtctgtg atgtaccaca tcaaactcaa ccaagtggcc atctctcagg ccctcagcaa   2700

tgctctccac tcgctggatg gggctacatc tcgtgcagat tttgtggcgc tgttggacca   2760

gttcggcaac cattacatcc aggaagctat ctacggcttt gaggagtcct gttctatctg   2820

gtacccaaac aagcaggtcc agcggcgact ctggctggag tatgaagaca tcagtaaagg   2880

caactcccca tcagatgagt ctgaggagcg ggaaagagac cccaaggtgc tgacattccc   2940

agaatacatc accagcttgt cagactccgg caccaagcac atggcggctg gagtccgcat   3000

ggagtgccac agcaagggac gatgcccctc gtcctgcccc ctgtgtcatg tgacatccag   3060

ccctgacacc cctgctgagc cggttctgct ggaggtgacc aaagcagccc ccatctatga   3120

actagtgacc aacaaccaga cccagaggct cttgcaggag gctaccatga gctctctctg   3180

gtgctcaggg actggagatg tcatcgagga ctggtgtcga tgtgactcca ctgcttttgg   3240

agctgatgga ctccccacct gtgcgcctct cccacagcct gtgctgagac tctccacggt   3300

tcacgagccc agcagcactc ttgtggtcct ggagtgggaa cactcagagc caccaatcgg   3360

ggtgcagatt gtagattacc tcctccgtca agagaaagtc actgacagga tggaccactc   3420

caaagtggag acagaaacag tgctgagctt tgtggacgac atcatctctg gagcaaagtc   3480

tccttgtgca atgccatctc aggtgccgga caagcagctc accaccatct ctctgatcat   3540

acgatgcctg gaacctgaca ccatttacat gttcacgctg tggggagtgg acaacacagg   3600

acggcgctcc aggccaagcg acgtgatcgt gaagacccca tgccccgtgg tggatgatgt   3660

caaggctcaa gaaatagcag acaagatcta caatctcttc aatggctaca ctagtgggaa   3720

ggagcagcag accgcctaca acaccctcct ggatctgggt tcccccacct tacaccgggt   3780

cctctaccac tataaccagc actatgagag ttttggggaa ttcacctggc gatgtgagga   3840

tgagttaggt cccaggaaag ctggtctcat cctttcccag cttggggacc tcagcagttg   3900

gtgcaatgga ctccttcagg aacccaagat aagcttgcgg cgcagctcac tcaagtacct   3960

ggggtgccgc tacagcgaga tcaaacccta cggacttgac tgggcggagc tcagccggga   4020

cctcaggaag acgtgtgagg agcagaccct gagtatcccc tacaacgact atggggacag   4080

caaagagatc tagcaccata aggccaggga gctgctgcca gaatgaagta ggaaagagga   4140

gggatccatc tgggttggtc tgtggatttt taatattttt taatggaaca tgaaaacctc   4200

cacagcaaca tcgaaaccag ggagaaagtg atccttgctc cctgcagaac ttcttcagta   4260

tgatgttctc catctgcatg attgggaaat ctgccagcca gtggcttcat gcagtgccat   4320

atttctttag aggattactt tggggtttgc tttgccatta atttgttcca ttcatttttt   4380

tttccctgag aagtttacca aaatgctcaa gagctctgcc gtgctcccca tgaaaagtct   4440

attaagtagg caccctgtgc tcactcagtt cctaaatcca ttgcaactgg gagcagaggt   4500

gaggccagaa agttgttagg cctgccgcag gccccaccct caagcattcc tcaggaagcg   4560

tctcactctg ggagccttgg ccctgctcac agagagagac aatagaaaat tgaggaaggt   4620

ggcccttgtc tgtgtctcct ggttttcttc ctaggccttg ctatcactat ttccataccc   4680

gaaaggtgaa accagctttc attataggcc ccagtgggcc acttgggttt tgagatcctt   4740

ccttatttta agccaggact gggattaaat ctccctctgt cagatctctg tcccttcctc   4800

tgaacaacat gatctttgag agggaacaag atgccatctg tcaactgcac cttcagaaaa   4860

gtctacctgg gagactagtt agcagtccac attcaagagg agacttggag tttattgttt   4920

tttaaaaaaa ccatgcttcc tttggataga cttctccagc ctaccaatat atatccatgt   4980

gcctggatta tctttaaccc ccacacctct taccttggac aggtaaggct tggccgatgt   5040

ctgattggga ccaggagggg tcaacacttt catatcagtg ttacagtgaa ctaaagctat   5100

tattgatcac aaaaaacttc tgttcatccc caccttgcta aatttgcttg tgttgctagt   5160

tttgcaaatc gtttctctga tgaccataag caggaggatt ccaccatggt cactgcccat   5220

ccagtcacag ggattctgtg tagggaagca ccactgattg cagttaacat ctagagtgtt   5280

gtttccatcc cactgcccaa gcattggcat ggtcatgaat ggtggcccag ccaacaggaa   5340

gcccagcctt tcagaaagag cctggcaagg ccctgttgac tagcaatggc cttagctgtc   5400

ccacacaact cagtggcctg aacacacacc ttcagccacc atgcctttga ccagggctcc   5460

tcatctggaa acatatgaga aaggtcagca aacagatgca agacctataa ggctagtcat   5520

tgagctatat tggttttttt tctaaatagt agtagtgaca gataacattt attgagtgct   5580

tgctgtatgc caggcgctga tgtaagcact ttaggtatca ttgaattctc acagcaactc   5640

ctgaggaaag tgctattctt gtctccattt tagtgttgag gaaaacgagg caaagagagg   5700

ttatacaact tgcctcaaat cccttgtgca ctgtaactca cactgagttt cagtgtgatt   5760

tcaggctgtt ggtctccagg gcacaggatc ttagctactc tgggataccc agttctgttt   5820

tcagtatcat ctggcacaca actgtccaag ctctcagccc cacagggaac ctgcccagag   5880

agctttacct ttcccaagca tctgtggcat ggacatgtcc tctgtgcagt ggaaggagga   5940

ggggcgaaag tacgccctta gcctttggag ctagagcacc cttgggaccc ctagttccac   6000

tgcacatggc cctcctcccc accctcatga ctgggaagga agcctgtgat gaggctgaga   6060

taaagcacag ggtggtttca ctctcctctc tccttctttc caaacactga aggatttatt   6120

tcaaactctc taatgcacct gcctcagaga ttcccctact ttcaaagcaa agatcagcag   6180

aaaaattggc tgtcccacct gtggcaaatg ctggagcctc agttaaagtg cctcaagggg   6240

caaatatttc accattgcca gagaagatgt gacaggccaa tcagacaggg cccagagcat   6300

ctctttgctg ctactgtttt gccatccttc tattcatatc tgtgcagaac acggtgtttt   6360

aagcttgagt gaaaggaggg tgaggctgcc gatgccttcc tgcccagaag tggatgatgt   6420

gggagttgac aggccaggga gagggtgaag caggtatcag agtcactcct ctgtaccctc   6480

tccttctgtt tttattttag gcacactatc ttcctctctc ctatctttcc ctcagtctcc   6540

caagttcctc taccttcttt atctttgtct tttacttctt ctttctgtga ccctcctttt   6600

ttggcctcct ctttccccaa gactttcttc ctcctgtttc tcgttgagtt ctccccactg   6660

aatgtgtgta tgtatgtaca cacacacaca cgtgtgcaca cacaatgcac acaactccta   6720

tgactggctc ctacttacat tcaagttaaa aaggctgata tgaacagggc aggggaaaat   6780

cttaggatgg ttgtacaatt gactggagga ttttttcccc ttggaagaca ctattgatct   6840

caacctgctg acttttccta atgcttacct gaaggaaccc atcctggcta gaaagggtga   6900

tggtactgga ccggtattca accttgagtt ttcaagctgc caaacaggtc ttaagggagg   6960

tgcttatatc ccaccaacac tctcccagct cccatgtccc caagacctct ggagtttcct   7020

cttgaatgta catgaaccac tgtaatagca ttagactttt aattgagtgt gcaatcgttt   7080

tccatggagt ttggtccgtt cattattttt tagttaacta cacttcttga tattcaaatg   7140

ttctattaaa aaaactgagt atgaagaaaa acactttact actgcagaag gaagaaagaa   7200

tataatatga ccatcttcag gtataacagt gttgtttaaa agagaattat tgtatgatta   7260

taaaagatga aataattaac tgaataataa aacaaagcta ttagtaagca ttg          7313


<210>  6738
<211>  1294
<212>  PRT
<213>  Homosapiens

<400>  6738

Met Ala Leu Ala Gly Leu Cys Ala Leu Leu Ala Cys Cys Trp Gly Pro 
1               5                   10                  15      


Ala Ala Val Leu Ala Thr Ala Ala Gly Asp Val Asp Pro Ser Lys Glu 
            20                  25                  30          


Leu Glu Cys Lys Leu Lys Ser Ile Thr Val Ser Ala Leu Pro Phe Leu 
        35                  40                  45              


Arg Glu Asn Asp Leu Ser Ile Met His Ser Pro Ser Ala Ser Glu Pro 
    50                  55                  60                  


Lys Leu Leu Phe Ser Val Arg Asn Asp Phe Pro Gly Glu Met Val Val 
65                  70                  75                  80  


Val Asp Asp Leu Glu Asn Thr Glu Leu Pro Tyr Phe Val Leu Glu Ile 
                85                  90                  95      


Ser Gly Asn Thr Glu Asp Ile Pro Leu Val Arg Trp Arg Gln Gln Trp 
            100                 105                 110         


Leu Glu Asn Gly Thr Leu Leu Phe His Ile His His Gln Asp Gly Ala 
        115                 120                 125             


Pro Ser Leu Pro Gly Gln Asp Pro Thr Glu Glu Pro Gln His Glu Ser 
    130                 135                 140                 


Ala Glu Glu Glu Leu Arg Ile Leu His Ile Ser Val Met Gly Gly Met 
145                 150                 155                 160 


Ile Ala Leu Leu Leu Ser Ile Leu Cys Leu Val Met Ile Leu Tyr Thr 
                165                 170                 175     


Arg Arg Arg Trp Cys Lys Arg Arg Arg Val Pro Gln Pro Gln Lys Ser 
            180                 185                 190         


Ala Ser Ala Glu Ala Ala Asn Glu Ile His Tyr Ile Pro Ser Val Leu 
        195                 200                 205             


Ile Gly Gly His Gly Arg Glu Ser Leu Arg Asn Ala Arg Val Gln Gly 
    210                 215                 220                 


His Asn Ser Ser Gly Thr Leu Ser Ile Arg Glu Thr Pro Ile Leu Asp 
225                 230                 235                 240 


Gly Tyr Glu Tyr Asp Ile Thr Asp Leu Arg His His Leu Gln Arg Glu 
                245                 250                 255     


Cys Met Asn Gly Gly Glu Asp Phe Ala Ser Gln Val Thr Arg Thr Leu 
            260                 265                 270         


Asp Ser Leu Gln Gly Cys Asn Glu Lys Ser Gly Met Asp Leu Thr Pro 
        275                 280                 285             


Gly Ser Asp Asn Ala Lys Leu Ser Leu Met Asn Lys Tyr Lys Asp Asn 
    290                 295                 300                 


Ile Ile Ala Thr Ser Pro Val Asp Ser Asn His Gln Gln Ala Thr Leu 
305                 310                 315                 320 


Leu Ser His Thr Ser Ser Ser Gln Arg Lys Arg Ile Asn Asn Lys Ala 
                325                 330                 335     


Arg Ala Gly Ser Ala Phe Leu Asn Pro Glu Gly Asp Ser Gly Thr Glu 
            340                 345                 350         


Ala Glu Asn Asp Pro Gln Leu Thr Phe Tyr Thr Asp Pro Ser Arg Ser 
        355                 360                 365             


Arg Arg Arg Ser Arg Val Gly Ser Pro Arg Ser Pro Val Asn Lys Thr 
    370                 375                 380                 


Thr Leu Thr Leu Ile Ser Ile Thr Ser Cys Val Ile Gly Leu Val Cys 
385                 390                 395                 400 


Ser Ser His Val Asn Cys Pro Leu Val Val Lys Ile Thr Leu His Val 
                405                 410                 415     


Pro Glu His Leu Ile Ala Asp Gly Ser Arg Phe Ile Leu Leu Glu Gly 
            420                 425                 430         


Ser Gln Leu Asp Ala Ser Asp Trp Leu Asn Pro Ala Gln Val Val Leu 
        435                 440                 445             


Phe Ser Gln Gln Asn Ser Ser Gly Pro Trp Ala Met Asp Leu Cys Ala 
    450                 455                 460                 


Arg Arg Leu Leu Asp Pro Cys Glu His Gln Cys Asp Pro Glu Thr Gly 
465                 470                 475                 480 


Glu Cys Leu Cys Tyr Glu Gly Tyr Met Lys Asp Pro Val His Lys His 
                485                 490                 495     


Leu Cys Ile Arg Asn Glu Trp Gly Thr Asn Gln Gly Pro Trp Pro Tyr 
            500                 505                 510         


Thr Ile Phe Gln Arg Gly Phe Asp Leu Val Leu Gly Glu Gln Pro Ser 
        515                 520                 525             


Asp Lys Ile Phe Arg Phe Thr Tyr Thr Leu Gly Glu Gly Met Trp Leu 
    530                 535                 540                 


Pro Leu Ser Lys Ser Phe Val Ile Pro Pro Ala Glu Leu Ala Ile Asn 
545                 550                 555                 560 


Pro Ser Ala Lys Cys Lys Thr Asp Met Thr Val Met Glu Asp Ala Val 
                565                 570                 575     


Glu Val Arg Glu Glu Leu Met Thr Ser Ser Ser Phe Asp Ser Leu Glu 
            580                 585                 590         


Val Leu Leu Asp Ser Phe Gly Pro Val Arg Asp Cys Ser Lys Asp Asn 
        595                 600                 605             


Gly Gly Cys Ser Lys Asn Phe Arg Cys Ile Ser Asp Arg Lys Leu Asp 
    610                 615                 620                 


Ser Thr Gly Cys Val Cys Pro Ser Gly Leu Ser Pro Met Lys Asp Ser 
625                 630                 635                 640 


Ser Gly Cys Tyr Asp Arg His Ile Gly Val Asp Cys Ser Asp Gly Phe 
                645                 650                 655     


Asn Gly Gly Cys Glu Gln Leu Cys Leu Gln Gln Met Ala Pro Phe Pro 
            660                 665                 670         


Asp Asp Pro Thr Leu Tyr Asn Ile Leu Met Phe Cys Gly Cys Ile Glu 
        675                 680                 685             


Asp Tyr Lys Leu Gly Val Asp Gly Arg Ser Cys Gln Leu Ile Thr Glu 
    690                 695                 700                 


Thr Cys Pro Glu Gly Ser Asp Cys Gly Glu Ser Arg Glu Leu Pro Met 
705                 710                 715                 720 


Asn Gln Thr Leu Phe Gly Glu Met Phe Phe Gly Tyr Asn Asn His Ser 
                725                 730                 735     


Lys Glu Val Ala Ala Gly Gln Val Leu Lys Gly Thr Phe Arg Gln Asn 
            740                 745                 750         


Asn Phe Ala Arg Gly Leu Asp Gln Gln Leu Pro Asp Gly Leu Val Val 
        755                 760                 765             


Ala Thr Val Pro Leu Glu Asn Gln Cys Leu Glu Glu Ile Ser Glu Pro 
    770                 775                 780                 


Thr Pro Asp Pro Asp Phe Leu Thr Gly Met Val Asn Phe Ser Glu Val 
785                 790                 795                 800 


Ser Gly Tyr Pro Val Leu Gln His Trp Lys Val Arg Ser Val Met Tyr 
                805                 810                 815     


His Ile Lys Leu Asn Gln Val Ala Ile Ser Gln Ala Leu Ser Asn Ala 
            820                 825                 830         


Leu His Ser Leu Asp Gly Ala Thr Ser Arg Ala Asp Phe Val Ala Leu 
        835                 840                 845             


Leu Asp Gln Phe Gly Asn His Tyr Ile Gln Glu Ala Ile Tyr Gly Phe 
    850                 855                 860                 


Glu Glu Ser Cys Ser Ile Trp Tyr Pro Asn Lys Gln Val Gln Arg Arg 
865                 870                 875                 880 


Leu Trp Leu Glu Tyr Glu Asp Ile Ser Lys Gly Asn Ser Pro Ser Asp 
                885                 890                 895     


Glu Ser Glu Glu Arg Glu Arg Asp Pro Lys Val Leu Thr Phe Pro Glu 
            900                 905                 910         


Tyr Ile Thr Ser Leu Ser Asp Ser Gly Thr Lys His Met Ala Ala Gly 
        915                 920                 925             


Val Arg Met Glu Cys His Ser Lys Gly Arg Cys Pro Ser Ser Cys Pro 
    930                 935                 940                 


Leu Cys His Val Thr Ser Ser Pro Asp Thr Pro Ala Glu Pro Val Leu 
945                 950                 955                 960 


Leu Glu Val Thr Lys Ala Ala Pro Ile Tyr Glu Leu Val Thr Asn Asn 
                965                 970                 975     


Gln Thr Gln Arg Leu Leu Gln Glu Ala Thr Met Ser Ser Leu Trp Cys 
            980                 985                 990         


Ser Gly Thr Gly Asp Val Ile Glu  Asp Trp Cys Arg Cys  Asp Ser Thr 
        995                 1000                 1005             


Ala Phe  Gly Ala Asp Gly Leu  Pro Thr Cys Ala Pro  Leu Pro Gln 
    1010                 1015                 1020             


Pro Val  Leu Arg Leu Ser Thr  Val His Glu Pro Ser  Ser Thr Leu 
    1025                 1030                 1035             


Val Val  Leu Glu Trp Glu His  Ser Glu Pro Pro Ile  Gly Val Gln 
    1040                 1045                 1050             


Ile Val  Asp Tyr Leu Leu Arg  Gln Glu Lys Val Thr  Asp Arg Met 
    1055                 1060                 1065             


Asp His  Ser Lys Val Glu Thr  Glu Thr Val Leu Ser  Phe Val Asp 
    1070                 1075                 1080             


Asp Ile  Ile Ser Gly Ala Lys  Ser Pro Cys Ala Met  Pro Ser Gln 
    1085                 1090                 1095             


Val Pro  Asp Lys Gln Leu Thr  Thr Ile Ser Leu Ile  Ile Arg Cys 
    1100                 1105                 1110             


Leu Glu  Pro Asp Thr Ile Tyr  Met Phe Thr Leu Trp  Gly Val Asp 
    1115                 1120                 1125             


Asn Thr  Gly Arg Arg Ser Arg  Pro Ser Asp Val Ile  Val Lys Thr 
    1130                 1135                 1140             


Pro Cys  Pro Val Val Asp Asp  Val Lys Ala Gln Glu  Ile Ala Asp 
    1145                 1150                 1155             


Lys Ile  Tyr Asn Leu Phe Asn  Gly Tyr Thr Ser Gly  Lys Glu Gln 
    1160                 1165                 1170             


Gln Thr  Ala Tyr Asn Thr Leu  Leu Asp Leu Gly Ser  Pro Thr Leu 
    1175                 1180                 1185             


His Arg  Val Leu Tyr His Tyr  Asn Gln His Tyr Glu  Ser Phe Gly 
    1190                 1195                 1200             


Glu Phe  Thr Trp Arg Cys Glu  Asp Glu Leu Gly Pro  Arg Lys Ala 
    1205                 1210                 1215             


Gly Leu  Ile Leu Ser Gln Leu  Gly Asp Leu Ser Ser  Trp Cys Asn 
    1220                 1225                 1230             


Gly Leu  Leu Gln Glu Pro Lys  Ile Ser Leu Arg Arg  Ser Ser Leu 
    1235                 1240                 1245             


Lys Tyr  Leu Gly Cys Arg Tyr  Ser Glu Ile Lys Pro  Tyr Gly Leu 
    1250                 1255                 1260             


Asp Trp  Ala Glu Leu Ser Arg  Asp Leu Arg Lys Thr  Cys Glu Glu 
    1265                 1270                 1275             


Gln Thr  Leu Ser Ile Pro Tyr  Asn Asp Tyr Gly Asp  Ser Lys Glu 
    1280                 1285                 1290             


Ile 
    


<210>  6739
<211>  3859
<212>  DNA
<213>  Homosapiens

<400>  6739
gctccgggaa acaaagaatc cggggctctc cagacatcag agcttaaacc caggactctg     60

caagcggcat ctcattccgg ggtccagggc tctcccggct ctccatcccc tccctaacct    120

cccccgcctc ccgcgctcgc tccctcgctc cctccccgct cgcttcctcc cccaccatcg    180

cagcgctagg aggaaggcgg ccggggctca agatggcttt agccgggctc tgcgccctgc    240

tcgcctgctg ctgggggccg gcggcggtgc tggccacggc cgccggcgac gtggatccat    300

ccaaggagct ggagtgcaag ctcaaaagca tcacggtgtc ggcactgccc ttcctgcgcg    360

agaacgacct gagcatcatg cacagcccct cggcctcgga gcccaagctc ctcttctcgg    420

tgcgcaacga cttcccggga gaaatggtcg tggtggacga cctggagaac acggagctgc    480

cctacttcgt gctggagatc tcagggaaca cagaggatat ccctttggtg cgctggaggc    540

agcagtggct ggagaatggc actttgcttt ttcacattca tcaccaagat ggtgccccaa    600

gccttcctgg acaagacccc actgaagaac cccaacatga gtcggcagaa gaggagctga    660

ggatcctcca catctcagtc atgggtggca tgatcgctct gctgctgtcc atcttgtgcc    720

tggtgatgat cctgtatact cgccggcgct ggtgcaaacg ccgccgggtc ccgcagcccc    780

agaagagtgc cagtgctgag gcagccaatg agattcacta cattccttct gtgctgatcg    840

gcgggcacgg acgggagagc ctgcgcaatg cccgcgtgca gggccacaac tccagtggca    900

ccctgagcat ccgggagaca cctatcctgg acggctatga gtatgacatc actgatctgc    960

gccaccatct gcagagggag tgcatgaacg gaggggagga ctttgccagc caggtcacgc   1020

gcaccctcga ctccctgcag ggctgcaatg aaaagtcggg gatggacctc acaccaggaa   1080

gtgacaatgc caagctgtca ctgatgaaca agtataaaga taatattata gccactagcc   1140

ctgtggactc caaccaccag caagccaccc ttctctctca cacctccagc agccagagaa   1200

agcggatcaa caacaaagca agagctggtt ccgccttctt gaaccctgaa ggggattctg   1260

gcacagaggc agaaaacgac ccccagctga ccttttacac ggatccttca aggagcagga   1320

ggcgtagtag agtgggttct ccccgaagtc ctgtgaataa gaccaccttg accctgatca   1380

gcatcaccag ctgtgtgatt ggcctcgtgt gctcctctca cgtcaactgc cctctcgttg   1440

tcaagatcac cctgcatgtc cctgagcacc tgattgctga tgggagccgc ttcatcttgc   1500

tggaggggag ccagctggat gccagtgact ggctgaaccc tgcccaagtg gttctcttct   1560

ctcagcagaa ctccagcgga ccctgggcca tggacctctg tgcccggcgg ctcctggacc   1620

cctgtgaaca ccaatgtgac cccgaaactg gggaatgcct ctgctatgaa ggctacatga   1680

aggatccagt acataagcac ctttgcattc ggaacgaatg ggggacaaac caggggccat   1740

ggccttacac aatatttcag cgaggctttg acctggtttt gggagagcag ccctctgata   1800

aaatatttag attcacctac actcttgggg agggcatgtg gttgcccctc agcaagagct   1860

ttgtgattcc accagccgaa ctggccatca atccatcagc aaagtgcaag acggacatga   1920

ctgtgatgga ggatgctgtg gaggtcagag aggagctgat gacttcatcc tccttcgaca   1980

gcctggaggt tctcttagat tcctttgggc cggtgcgcga ctgcagcaaa gataacgggg   2040

gctgcagtaa gaatttccgc tgtatttcag atcgcaagct ggactccact ggttgcgtgt   2100

gcccatctgg actcagtccc atgaaggaca gctctggctg ctatgaccgc cacatcgggg   2160

tggactgttc cgacggcttc aacggcggct gtgagcagct gtgcctccag cagatggcgc   2220

ccttcccgga cgaccccacc ttgtataaca tcctcatgtt ctgtgggtgc atcgaggact   2280

acaagcttgg tgtggatgga cgctcttgcc aactcatcac ggagacctgt ccagagggaa   2340

gtgactgtgg ggaaagcagg gagcttccca tgaaccagac cctctttggg gagatgttct   2400

ttggttacaa caaccattcc aaggaagtgg ctgccggaca ggtgctgaaa ggaacattca   2460

ggcaaaacaa ctttgctcgt ggtttagacc agcaactgcc agatggtctt gtggtggcca   2520

ctgtgcccct ggagaatcaa tgcctagagg agatctcgga gcccacccct gaccctgact   2580

tcctgactgg gatggtgaac ttcagtgaag tgtctgggta ccctgtgctg cagcactgga   2640

aggtccggtc tgtgatgtac cacatcaaac tcaaccaagt ggccatctct caggccctca   2700

gcaatgctct ccactcgctg gatggggcta catctcgtgc agattttgtg gcgctgttgg   2760

accagttcgg caaccattac atccaggaag ctatctacgg ctttgaggag tcctgttcta   2820

tctggtaccc aaacaagcag gtccagcggc gactctggct ggagtatgaa gacatcagta   2880

aaggcaactc cccatcagat gagtctgagg agcgggaaag agaccccaag gtgctgacat   2940

tcccagaata catcaccagc ttgtcagact ccggcaccaa gcacatggcg gctggagtcc   3000

gcatggagtg ccacagcaag ggacgatgcc cctcgtcctg ccccctgtgt catgtgacat   3060

ccagccctga cacccctgct gagccggttc tgctggaggt gaccaaagca gcccccatct   3120

atgaactagt gaccaacaac cagacccaga ggctcttgca ggaggctacc atgagctctc   3180

tctggtgctc agggactgga gatgtcatcg aggactggtg tcgatgtgac tccactgctt   3240

ttggagctga tggactcccc acctgtgcgc ctctcccaca gcctgtgctg agactctcca   3300

cggttcacga gcccagcagc actcttgtgg tcctggagtg ggaacactca gagccaccaa   3360

tcggggtgca gattgtagat tacctcctcc gtcaagagaa agtcactgac aggatggacc   3420

actccaaagt ggagacagaa acagtgctga gctttgtgga cgacatcatc tctggagcaa   3480

agtctccttg tgcaatgcca tctcaggtgc cggacaagca gctcaccacc atctctctga   3540

tcatacgatg cctggaacct gacaccattt acatgttcac gctgtgggga gtggacaaca   3600

caggacggcg ctccaggcca agcgacgtga tcgtgaagac cccatgcccc gtggtggatg   3660

atgtcaaggc tcaagaaata gcagacaaga tctacaatct cttcaatggc tacactagtg   3720

ggaaggagca gcagaccgcc tacaacaccc tcctggatct gggttccccc accttacacc   3780

gggtcctcta ccactataac cagcactatg agagttttgg ggaattcacc tggcgatgtg   3840

aggatgagtt aggtcccag                                                3859


<210>  6740
<211>  1214
<212>  PRT
<213>  Homosapiens

<400>  6740

Met Ala Leu Ala Gly Leu Cys Ala Leu Leu Ala Cys Cys Trp Gly Pro 
1               5                   10                  15      


Ala Ala Val Leu Ala Thr Ala Ala Gly Asp Val Asp Pro Ser Lys Glu 
            20                  25                  30          


Leu Glu Cys Lys Leu Lys Ser Ile Thr Val Ser Ala Leu Pro Phe Leu 
        35                  40                  45              


Arg Glu Asn Asp Leu Ser Ile Met His Ser Pro Ser Ala Ser Glu Pro 
    50                  55                  60                  


Lys Leu Leu Phe Ser Val Arg Asn Asp Phe Pro Gly Glu Met Val Val 
65                  70                  75                  80  


Val Asp Asp Leu Glu Asn Thr Glu Leu Pro Tyr Phe Val Leu Glu Ile 
                85                  90                  95      


Ser Gly Asn Thr Glu Asp Ile Pro Leu Val Arg Trp Arg Gln Gln Trp 
            100                 105                 110         


Leu Glu Asn Gly Thr Leu Leu Phe His Ile His His Gln Asp Gly Ala 
        115                 120                 125             


Pro Ser Leu Pro Gly Gln Asp Pro Thr Glu Glu Pro Gln His Glu Ser 
    130                 135                 140                 


Ala Glu Glu Glu Leu Arg Ile Leu His Ile Ser Val Met Gly Gly Met 
145                 150                 155                 160 


Ile Ala Leu Leu Leu Ser Ile Leu Cys Leu Val Met Ile Leu Tyr Thr 
                165                 170                 175     


Arg Arg Arg Trp Cys Lys Arg Arg Arg Val Pro Gln Pro Gln Lys Ser 
            180                 185                 190         


Ala Ser Ala Glu Ala Ala Asn Glu Ile His Tyr Ile Pro Ser Val Leu 
        195                 200                 205             


Ile Gly Gly His Gly Arg Glu Ser Leu Arg Asn Ala Arg Val Gln Gly 
    210                 215                 220                 


His Asn Ser Ser Gly Thr Leu Ser Ile Arg Glu Thr Pro Ile Leu Asp 
225                 230                 235                 240 


Gly Tyr Glu Tyr Asp Ile Thr Asp Leu Arg His His Leu Gln Arg Glu 
                245                 250                 255     


Cys Met Asn Gly Gly Glu Asp Phe Ala Ser Gln Val Thr Arg Thr Leu 
            260                 265                 270         


Asp Ser Leu Gln Gly Cys Asn Glu Lys Ser Gly Met Asp Leu Thr Pro 
        275                 280                 285             


Gly Ser Asp Asn Ala Lys Leu Ser Leu Met Asn Lys Tyr Lys Asp Asn 
    290                 295                 300                 


Ile Ile Ala Thr Ser Pro Val Asp Ser Asn His Gln Gln Ala Thr Leu 
305                 310                 315                 320 


Leu Ser His Thr Ser Ser Ser Gln Arg Lys Arg Ile Asn Asn Lys Ala 
                325                 330                 335     


Arg Ala Gly Ser Ala Phe Leu Asn Pro Glu Gly Asp Ser Gly Thr Glu 
            340                 345                 350         


Ala Glu Asn Asp Pro Gln Leu Thr Phe Tyr Thr Asp Pro Ser Arg Ser 
        355                 360                 365             


Arg Arg Arg Ser Arg Val Gly Ser Pro Arg Ser Pro Val Asn Lys Thr 
    370                 375                 380                 


Thr Leu Thr Leu Ile Ser Ile Thr Ser Cys Val Ile Gly Leu Val Cys 
385                 390                 395                 400 


Ser Ser His Val Asn Cys Pro Leu Val Val Lys Ile Thr Leu His Val 
                405                 410                 415     


Pro Glu His Leu Ile Ala Asp Gly Ser Arg Phe Ile Leu Leu Glu Gly 
            420                 425                 430         


Ser Gln Leu Asp Ala Ser Asp Trp Leu Asn Pro Ala Gln Val Val Leu 
        435                 440                 445             


Phe Ser Gln Gln Asn Ser Ser Gly Pro Trp Ala Met Asp Leu Cys Ala 
    450                 455                 460                 


Arg Arg Leu Leu Asp Pro Cys Glu His Gln Cys Asp Pro Glu Thr Gly 
465                 470                 475                 480 


Glu Cys Leu Cys Tyr Glu Gly Tyr Met Lys Asp Pro Val His Lys His 
                485                 490                 495     


Leu Cys Ile Arg Asn Glu Trp Gly Thr Asn Gln Gly Pro Trp Pro Tyr 
            500                 505                 510         


Thr Ile Phe Gln Arg Gly Phe Asp Leu Val Leu Gly Glu Gln Pro Ser 
        515                 520                 525             


Asp Lys Ile Phe Arg Phe Thr Tyr Thr Leu Gly Glu Gly Met Trp Leu 
    530                 535                 540                 


Pro Leu Ser Lys Ser Phe Val Ile Pro Pro Ala Glu Leu Ala Ile Asn 
545                 550                 555                 560 


Pro Ser Ala Lys Cys Lys Thr Asp Met Thr Val Met Glu Asp Ala Val 
                565                 570                 575     


Glu Val Arg Glu Glu Leu Met Thr Ser Ser Ser Phe Asp Ser Leu Glu 
            580                 585                 590         


Val Leu Leu Asp Ser Phe Gly Pro Val Arg Asp Cys Ser Lys Asp Asn 
        595                 600                 605             


Gly Gly Cys Ser Lys Asn Phe Arg Cys Ile Ser Asp Arg Lys Leu Asp 
    610                 615                 620                 


Ser Thr Gly Cys Val Cys Pro Ser Gly Leu Ser Pro Met Lys Asp Ser 
625                 630                 635                 640 


Ser Gly Cys Tyr Asp Arg His Ile Gly Val Asp Cys Ser Asp Gly Phe 
                645                 650                 655     


Asn Gly Gly Cys Glu Gln Leu Cys Leu Gln Gln Met Ala Pro Phe Pro 
            660                 665                 670         


Asp Asp Pro Thr Leu Tyr Asn Ile Leu Met Phe Cys Gly Cys Ile Glu 
        675                 680                 685             


Asp Tyr Lys Leu Gly Val Asp Gly Arg Ser Cys Gln Leu Ile Thr Glu 
    690                 695                 700                 


Thr Cys Pro Glu Gly Ser Asp Cys Gly Glu Ser Arg Glu Leu Pro Met 
705                 710                 715                 720 


Asn Gln Thr Leu Phe Gly Glu Met Phe Phe Gly Tyr Asn Asn His Ser 
                725                 730                 735     


Lys Glu Val Ala Ala Gly Gln Val Leu Lys Gly Thr Phe Arg Gln Asn 
            740                 745                 750         


Asn Phe Ala Arg Gly Leu Asp Gln Gln Leu Pro Asp Gly Leu Val Val 
        755                 760                 765             


Ala Thr Val Pro Leu Glu Asn Gln Cys Leu Glu Glu Ile Ser Glu Pro 
    770                 775                 780                 


Thr Pro Asp Pro Asp Phe Leu Thr Gly Met Val Asn Phe Ser Glu Val 
785                 790                 795                 800 


Ser Gly Tyr Pro Val Leu Gln His Trp Lys Val Arg Ser Val Met Tyr 
                805                 810                 815     


His Ile Lys Leu Asn Gln Val Ala Ile Ser Gln Ala Leu Ser Asn Ala 
            820                 825                 830         


Leu His Ser Leu Asp Gly Ala Thr Ser Arg Ala Asp Phe Val Ala Leu 
        835                 840                 845             


Leu Asp Gln Phe Gly Asn His Tyr Ile Gln Glu Ala Ile Tyr Gly Phe 
    850                 855                 860                 


Glu Glu Ser Cys Ser Ile Trp Tyr Pro Asn Lys Gln Val Gln Arg Arg 
865                 870                 875                 880 


Leu Trp Leu Glu Tyr Glu Asp Ile Ser Lys Gly Asn Ser Pro Ser Asp 
                885                 890                 895     


Glu Ser Glu Glu Arg Glu Arg Asp Pro Lys Val Leu Thr Phe Pro Glu 
            900                 905                 910         


Tyr Ile Thr Ser Leu Ser Asp Ser Gly Thr Lys His Met Ala Ala Gly 
        915                 920                 925             


Val Arg Met Glu Cys His Ser Lys Gly Arg Cys Pro Ser Ser Cys Pro 
    930                 935                 940                 


Leu Cys His Val Thr Ser Ser Pro Asp Thr Pro Ala Glu Pro Val Leu 
945                 950                 955                 960 


Leu Glu Val Thr Lys Ala Ala Pro Ile Tyr Glu Leu Val Thr Asn Asn 
                965                 970                 975     


Gln Thr Gln Arg Leu Leu Gln Glu Ala Thr Met Ser Ser Leu Trp Cys 
            980                 985                 990         


Ser Gly Thr Gly Asp Val Ile Glu  Asp Trp Cys Arg Cys  Asp Ser Thr 
        995                 1000                 1005             


Ala Phe  Gly Ala Asp Gly Leu  Pro Thr Cys Ala Pro  Leu Pro Gln 
    1010                 1015                 1020             


Pro Val  Leu Arg Leu Ser Thr  Val His Glu Pro Ser  Ser Thr Leu 
    1025                 1030                 1035             


Val Val  Leu Glu Trp Glu His  Ser Glu Pro Pro Ile  Gly Val Gln 
    1040                 1045                 1050             


Ile Val  Asp Tyr Leu Leu Arg  Gln Glu Lys Val Thr  Asp Arg Met 
    1055                 1060                 1065             


Asp His  Ser Lys Val Glu Thr  Glu Thr Val Leu Ser  Phe Val Asp 
    1070                 1075                 1080             


Asp Ile  Ile Ser Gly Ala Lys  Ser Pro Cys Ala Met  Pro Ser Gln 
    1085                 1090                 1095             


Val Pro  Asp Lys Gln Leu Thr  Thr Ile Ser Leu Ile  Ile Arg Cys 
    1100                 1105                 1110             


Leu Glu  Pro Asp Thr Ile Tyr  Met Phe Thr Leu Trp  Gly Val Asp 
    1115                 1120                 1125             


Asn Thr  Gly Arg Arg Ser Arg  Pro Ser Asp Val Ile  Val Lys Thr 
    1130                 1135                 1140             


Pro Cys  Pro Val Val Asp Asp  Val Lys Ala Gln Glu  Ile Ala Asp 
    1145                 1150                 1155             


Lys Ile  Tyr Asn Leu Phe Asn  Gly Tyr Thr Ser Gly  Lys Glu Gln 
    1160                 1165                 1170             


Gln Thr  Ala Tyr Asn Thr Leu  Leu Asp Leu Gly Ser  Pro Thr Leu 
    1175                 1180                 1185             


His Arg  Val Leu Tyr His Tyr  Asn Gln His Tyr Glu  Ser Phe Gly 
    1190                 1195                 1200             


Glu Phe  Thr Trp Arg Cys Glu  Asp Glu Leu Gly 
    1205                 1210                 


<210>  6741
<211>  2104
<212>  DNA
<213>  Homosapiens

<400>  6741
gcaaacgccg ccgggtcccg cagccccaga agagtgccag tgctgaggca gccaatgaga     60

ttcactacat tccttctgtg ctgatcggcg ggcacggacg ggagagcctg cgcaatgccc    120

gcgtgcaggg ccacaactcc agtggcaccc tgagcatccg ggagacacct atcctggacg    180

gctatgagta tgacatcact gatctgcgcc accatctgca gagggagtgc atgaacggag    240

gggaggactt tgccagccag gtcacgcgca ccctcgactc cctgcagggc tgcaatgaaa    300

agtcggggat ggacctcaca ccaggaagtg acaatgccaa gctgtcactg atgaacaagt    360

ataaagataa tattatagcc actagccctg tggactccaa ccaccagcaa gccacccttc    420

tctctcacac ctccagcagc cagagaaagc ggatcaacaa caaagcaaga gctggttccg    480

ccttcttgaa ccctgaaggg gattctggca cagaggcaga aaacgacccc cagctgacct    540

tttacacgga tccttcaagg agcaggaggc gtagtagagt gggttctccc cgaagtcctg    600

tgaataagac caccttgacc ctgatcagca tcaccagctg tgtgattggc ctcgtgtgct    660

cctctcacgt caactgccct ctcgttgtca agatcaccct gcatgtccct gagcacctga    720

ttgctgatga actccagcgg accctgggcc atggacctct gtgcccggcg gctcctggac    780

ccctgtgaac accaatgtga ccccgaaact ggggaatgcc tctgctatga aggctacatg    840

aaggatccag tacataagca cctttgcatt cggaacgaat gggggacaaa ccagggcaca    900

gtgaactgaa tagagccacc accacctggt attcaagccg aactatgaga atcatgccag    960

actcctctct ctccttcatc gtcacatcca atcaatcacc acatcatgat tgctctactc   1020

cctcaatatc acttggagct ctccagctct gattgctaca ggcattcctt ggcttggaga   1080

tgcatcactt cagtctctgc ctccgtcttc ttgtggcatt ctccctgtgt gtgtctgtgt   1140

ctcacgtggc catcctctta aaaggacacc agtcatattg gattttggca ccccctactc   1200

caggctgacc tcatcttaac taattacacc tgcaaagacc ctatttccaa ataagggatg   1260

gatttgcaca ggtccattgc caagctcttg tcctgttcat ttgtgagcaa agatgggtgt   1320

ccggggacac atggcagact gtgcccattg acgggagtaa gcgagctgaa caagctttca   1380

ggaccactga acttgagacc ttggctatat gagcccaggg taaaagtcaa ctgagccttg   1440

agatgcagaa ccagagagaa gtggagggag gaagacagta gttactatta tcaccatttt   1500

acagaaaaag gaaactgaag cttggaaagg tcaaatatct ttagctgtat cagttgcatg   1560

aagttagcaa gagacttgaa tccagaactt ggacttgaat ggagatctat ctgacttcag   1620

agctaaccca caaaacccca gccatggtga gactgtcttg gggtgatttg tatgggagac   1680

tgcagggtca gtgttggtca gcgacggacc ctgctctcag catgctcttt ctgcctgact   1740

gctttcagtg tctgcagcag ctgctagcag ggtgagagag gaggaagaga gcagtcgtga   1800

gtctcaccag ccatctgact ccctacccac aaagaaaatg ctgcagctgt gacatgtgtg   1860

tttgtcagtg tgtgtcacat gtgcacgacc acatgtgtgt atgtgtgcat aggtgggggc   1920

atctgtacct gtagatgcat ttctgaatgt aggaaaatct caatgctgca tagtactgtt   1980

ttcatggaac tgttgatcct cagaaataga aatgattgac agtttttcaa aaatgaatat   2040

gcatctcata taattgtaat gagatttggg atatcttaat tcatcaataa aggggacagg   2100

aagg                                                                2104


<210>  6742
<211>  185
<212>  PRT
<213>  Homosapiens

<400>  6742

Met Asn Gly Gly Glu Asp Phe Ala Ser Gln Val Thr Arg Thr Leu Asp 
1               5                   10                  15      


Ser Leu Gln Gly Cys Asn Glu Lys Ser Gly Met Asp Leu Thr Pro Gly 
            20                  25                  30          


Ser Asp Asn Ala Lys Leu Ser Leu Met Asn Lys Tyr Lys Asp Asn Ile 
        35                  40                  45              


Ile Ala Thr Ser Pro Val Asp Ser Asn His Gln Gln Ala Thr Leu Leu 
    50                  55                  60                  


Ser His Thr Ser Ser Ser Gln Arg Lys Arg Ile Asn Asn Lys Ala Arg 
65                  70                  75                  80  


Ala Gly Ser Ala Phe Leu Asn Pro Glu Gly Asp Ser Gly Thr Glu Ala 
                85                  90                  95      


Glu Asn Asp Pro Gln Leu Thr Phe Tyr Thr Asp Pro Ser Arg Ser Arg 
            100                 105                 110         


Arg Arg Ser Arg Val Gly Ser Pro Arg Ser Pro Val Asn Lys Thr Thr 
        115                 120                 125             


Leu Thr Leu Ile Ser Ile Thr Ser Cys Val Ile Gly Leu Val Cys Ser 
    130                 135                 140                 


Ser His Val Asn Cys Pro Leu Val Val Lys Ile Thr Leu His Val Pro 
145                 150                 155                 160 


Glu His Leu Ile Ala Asp Glu Leu Gln Arg Thr Leu Gly His Gly Pro 
                165                 170                 175     


Leu Cys Pro Ala Ala Pro Gly Pro Leu 
            180                 185 


<210>  6743
<211>  2813
<212>  DNA
<213>  Homosapiens

<400>  6743
gggcagttgg gattctccgt acgcctcgga aacagcagcc caaacctcac aacgcagaac     60

cacgagatag tggggattgc agagccctgc gcaagagaag gaaaattaag acgcagcgga    120

gcccaggagg tgcccgcacg cgggaaggac tggcgtgcag acgaggcagg gggaggtttg    180

cactcggcgt ggcgcgggtg agccgcgtgc tctcgggcac ccggccgcca gttcggatgc    240

ttccgatcct cggggagccg gggcgctgcg ccggagtcac ttcagcccat gttgttcagg    300

tgacacccgg ggaagagcag actccagtgt gcaaaacgtt tcggggtttc cgggccagcg    360

gttccgggcg cgcctcgcgg gcggcggcgc agaactacaa cccccaggct ccctggcgtg    420

gcggcacgtg ggcccgagcc gggcggccgc ggatataaag cgcggcggcg gctgccgggc    480

ggagcggctg cacggacaag agcggaggcc tggaagggga aactgaagca gaaagaggtt    540

acttaatggg ctcaaggtca cctacctgac ctaccagcag ctcaatggcc ttcccaaaga    600

agaaacttca gggtcttgtg gctgcaacca tcacgccaat gactgagaat ggagaaatca    660

acttttcagt aattggtcag tatgtggatt atcttgtgaa agaacaggga gtgaagaaca    720

tttttgtgaa tggcacaaca ggagaaggcc tgtccctgag cgtctcagag cgtcgccagg    780

ttgcagagga gtgggtgaca aaagggaagg acaagtcaaa ccatcataag ttggggacca    840

tccgcacaac ccaaagtaga cggagtagct ttagaagaca gctgaaggcc tggcacagtg    900

gctcacacct gtaatcccag cactttggga ggccaagtgg tagctgtgcc tagcagccca    960

ggagaaagag gaagagcaaa tggatgattg gcttcaccta aaccaagaga aaggggtagt   1020

gaagggaggg gtcgtgcaat aaaactgctg gtgagagttc aacaggctgg atcaggtgat   1080

aattcacgta ggagcactga gcttgaagga gtcacaggaa ctggcccaac atgcagcaga   1140

aataggagct gatggcatcg ctgtcattgc accgttcttc ctcaagccat ggaccaaaga   1200

tatcctgatt aatttcctaa aggaagtggc tgctgccgcc cctgccctgc cattttatta   1260

ctatcacatt cctgccttga caggggtaaa gattcgtgct gaggagttgt tggatgggat   1320

tctggataag atccccacct tccaagggct gaaattcagt gatacagatc tcttagactt   1380

cgggcaatgt gttgatcaga atcgccagca acagtttgct ttcctttttg gggtggatga   1440

gcaactgttg agtgctctgg tgatgggagc aactggagca gtgggcagta cctataacta   1500

cctgggaaaa aagacaaacc agatgttgga ggcttttgaa caaaaggact tctctttagc   1560

cctgaactat cagttttgta tccagagatt tatcaacttt gttgtcaaac taggtaagtg   1620

ccacccatct tctgctttgt ctgctgctgg agactgtaaa gaaaatggaa taccatcact   1680

ttctctgagg gttcaacaag aacacttttt aatggtctgt tgcaagcaga gttctgtttc   1740

ccttattaac cctcggggcc aaccatataa aactgtgaag taaacctagt tggaaaatct   1800

ttggcaacct tctccatttt agcacatgcc taccccattt tccattcttt ctctcctaaa   1860

ccatcagcac tccctccctt tacttgcttc agctcattaa aattctacta ctgcattgag   1920

gttgatttca gcctaagtgc ttggaggaag gcagtctaaa tacagatttt actaaattgt   1980

gaatgactga cagctctccc aagagtattt acaatttaaa cagagtttat taacacaagt   2040

aagcctaaat ggatggaggt ttggataata tgacaaagta aaattgggga gcagtcgtgg   2100

ggagaaatac agtgaatttg agtagagaaa ccgctccaga gtctcttaaa tcttctataa   2160

caaatgacaa atgccactat ccactcttct gcaagagatt ggcccttggg ccaattgaat   2220

ctgcgttaat gcaggaaaat ttttaagttt atttttggta gacctccctg ctccctgtca   2280

gagtcctgca taattctgac aactcctccc tctcccccaa gcacctcttc tgtgttatgc   2340

ccctcattct tgcagggttc tcaacccact ctcttactcc ttcaaggacg tttctgtttg   2400

tttttccact ttcgtgattt ttgcacattt gtgtgctgcc agtgctatga actacctatt   2460

attgttccat ttttctaagc aatggtttca caaaattgtg ggtttggtgt gataattatt   2520

atgttcctaa aatacattaa aataggtatt gaactgttaa aattttagac aaactaaaag   2580

cttgatgtgt gtagtagtcc ccccttatct cagggggata tgttccaaga tgaccagtgg   2640

atgcctgaaa ttgcagataa tacgaaaccc tatatatact atgttttttc ctgtacatgc   2700

atacctatgg taaagtttaa tttataaatt aggcatagta agagataaac agtaactaat   2760

aataaaatag aacaattata acaatatact gcaataaaag ttatataact atg          2813


<210>  6744
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  6744

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Ser Asn His 
65                  70                  75                  80  


His Lys Leu Gly Thr Ile Arg Thr Thr Gln Ser Arg Arg Ser Ser Phe 
                85                  90                  95      


Arg Arg Gln Leu Lys Ala Trp His Ser Gly Ser His Leu 
            100                 105                 


<210>  6745
<211>  1581
<212>  DNA
<213>  Homosapiens

<400>  6745
gggcagttgg gattctccgt acgcctcgga aacagcagcc caaacctcac aacgcagaac     60

cacgagatag tggggattgc agagccctgc gcaagagaag gaaaattaag acgcagcgga    120

gcccaggagg tgcccgcacg cgggaaggac tggcgtgcag acgaggcagg gggaggtttg    180

cactcggcgt ggcgcgggtg agccgcgtgc tctcgggcac ccggccgcca gttcggatgc    240

ttccgatcct cggggagccg gggcgctgcg ccggagtcac ttcagcccat gttgttcagg    300

tgacacccgg ggaagagcag actccagtgt gcaaaacgtt tcggggtttc cgggccagcg    360

gttccgggcg cgcctcgcgg gcggcggcgc agaactacaa cccccaggct ccctggcgtg    420

gcggcacgtg ggcccgagcc gggcggccgc ggatataaag cgcggcggcg gctgccgggc    480

ggagcggctg cacggacaag agcggaggcc tggaagggga aactgaagca gaaagaggtt    540

acttaatggg ctcaaggtca cctacctgac ctaccagcag ctcaatggcc ttcccaaaga    600

agaaacttca gggtcttgtg gctgcaacca tcacgccaat gactgagaat ggagaaatca    660

acttttcagt aattggtcag tatgtggatt atcttgtgaa agaacaggga gtgaagaaca    720

tttttgtgaa tggcacaaca ggagaaggcc tgtccctgag cgtctcagag cgtcgccagg    780

ttgcagagga gtgggtgaca aaagggaagg acaagctgga tcaggtgata attcacgtag    840

gagcactgag cttgaaggag tcacaggaac tggcccaaca tgcagcagaa ataggagctg    900

atggcatcgc tgtcattgca ccgttcttcc tcaagccatg gaccaaagat atcctgatta    960

atttcctaaa ggaagtggct gctgccgccc ctgccctgcc attttattac tatcacattc   1020

ctgccttgac aggggtaaag attcgtgctg aggagttgtt ggatgggatt ctggataaga   1080

tccccacctt ccaagggctg aaattcagtg atacagatct cttagacttc gggcaatgtg   1140

ttgatcagaa tcgccagcaa cagtttgctt tcctttttgg ggtggatgag caactgttga   1200

gtgctctggt gatgggagca actggagcag tgggcagttt tgtatccaga gatttatcaa   1260

ctttgttgtc aaactaggtt ttggagtgtc acagaccaaa gccatcatga ctctggtctc   1320

tgggattcca atgggcccac cccggcttcc actgcagaaa gcctccaggg agtttactga   1380

tagtgctgaa gctaaactga agagcctgga tttcctttct ttcactgatt taaaggatgg   1440

aaacttggaa gctggtagct agtgcctctc tatcaaatca gggtttgcac cttgagacat   1500

aatctacctt aaatagtgca tttttttctc agggaatttt agatgaactt gaataaactc   1560

tcctagcaaa tgaaatctca c                                             1581


<210>  6746
<211>  230
<212>  PRT
<213>  Homosapiens

<400>  6746

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Phe Val Ser Arg Asp Leu 
    210                 215                 220                 


Ser Thr Leu Leu Ser Asn 
225                 230 


<210>  6747
<211>  2782
<212>  DNA
<213>  Homosapiens

<400>  6747
gggcagttgg gattctccgt acgcctcgga aacagcagcc caaacctcac aacgcagaac     60

cacgagatag tggggattgc agagccctgc gcaagagaag gaaaattaag acgcagcgga    120

gcccaggagg tgcccgcacg cgggaaggac tggcgtgcag acgaggcagg gggaggtttg    180

cactcggcgt ggcgcgggtg agccgcgtgc tctcgggcac ccggccgcca gttcggatgc    240

ttccgatcct cggggagccg gggcgctgcg ccggagtcac ttcagcccat gttgttcagg    300

tgacacccgg ggaagagcag actccagtgt gcaaaacgtt tcggggtttc cgggccagcg    360

gttccgggcg cgcctcgcgg gcggcggcgc agaactacaa cccccaggct ccctggcgtg    420

gcggcacgtg ggcccgagcc gggcggccgc ggatataaag cgcggcggcg gctgccgggc    480

ggagcggctg cacggacaag agcggaggcc tggaagggga aactgaagca gaaagaggtt    540

acttaatggg ctcaaggtca cctacctgac ctaccagcag ctcaatggcc ttcccaaaga    600

agaaacttca gggtcttgtg gctgcaacca tcacgccaat gactgagaat ggagaaatca    660

acttttcagt aattggtcag tatgtggatt atcttgtgaa agaacaggga gtgaagaaca    720

tttttgtgaa tggcacaaca ggagaaggcc tgtccctgag cgtctcagag cgtcgccagg    780

ttgcagagga gtgggtgaca aaagggaagg acaagctgga tcaggtgata attcacgtag    840

gagcactgag cttgaaggag tcacaggaac tggcccaaca tgcagcagaa ataggagctg    900

atggcatcgc tgtcattgca ccgttcttcc tcaagccatg gaccaaagat atcctgatta    960

atttcctaaa ggaagtggct gctgccgccc ctgccctgcc attttattac tatcacattc   1020

ctgccttgac aggggtaaag attcgtgctg aggagttgtt ggatgggatt ctggataaga   1080

tccccacctt ccaagggctg aaattcagtg atacagatct cttagacttc gggcaatgtg   1140

ttgatcagaa tcgccagcaa cagtttgctt tcctttttgg ggtggatgag caactgttga   1200

gtgctctggt gatgggagca actggagcag tgggcagtac ctataactac ctgggaaaaa   1260

agacaaacca gatgttggag gcttttgaac aaaaggactt ctctttagcc ctgaactatc   1320

agttttgtat ccagagattt atcaactttg ttgtcaaact aggttttgga gtgtcacaga   1380

ccaaagccat catgactctg gtctctggga ttccaatggg cccaccccgg cttccactgc   1440

agaaagcctc cagggagttt actgatagtg ctgaagctaa actgaagagc ctggatttcc   1500

tttctttcac tgatttaaag gatggaaact tggaagctgg tagctagtgc ctctctatca   1560

aatcagggtt tgcaccttga gacataatct accttaaata gtgcattttt ttctcaggga   1620

attttagatg aacttgaata aactctccta gcaaatgaaa tctcacaata agcattgagg   1680

taccttttgt gagccttaaa aagtcttatt ttgtgaaggg gcaaaaactc taggagtcac   1740

aactctcagt cattcatttc acagattttt ttgtggagaa atttctgttt atatggatga   1800

aatggaatca agaggaaaat tgtaattgat taattccatc tgtctttagg agctctcatt   1860

atctcggtct ctggttccta atcctatttt aaagttgtct aattttaaac cactataata   1920

tgtcttcatt ttaataaata ttcatttgga atctaggaaa actctgagct actgcattta   1980

ggcaggcact ttaataccaa actgtaacat gtctcaactg tatacaactc aaaatacacc   2040

agctcatttg gctgctcagt ctaactctag aatggatgct tttgaattca tttcgatgtc   2100

accacttttc gctctttaaa aacactgggt caggtgagga cttgtttcag ttcctataac   2160

taagtaaagg gcggctttct cataacaaag gaaaaagtct tccccaaaga tgaatttaag   2220

tctccacttt tttctataca gaaaactcaa aactcaaagt ttcaaagaac caaaggactc   2280

ttcctctggg caccacaaac ttccccttcc tccactgaga agactgtctc tcccgcagga   2340

ccctgaatta ttgaaatcga aggctgactt cctttctgca gtgagcccag gggctaatgt   2400

tattatcctg tcacacttgc aactagtgac ttttgtttag tgatagaaga tttggggagg   2460

acccaaagga ctcagaactt tctctccata cctcctttta ctcttttctt tctgtgtaat   2520

gtatcaacaa ctgtttaatc tcccttctaa caaaccttga tataagcttt ctgatatcaa   2580

agtatattga cagttaaccc ttactgattt taaacttgac tatccagtct gttaattacc   2640

taagattttg ttttcatttc atctctaatt gttttgatca ttggcagaga aagagtattt   2700

gaaattcata tcagttttgc tccttatttt aatctctttg aattaaaaat aaaacttttt   2760

caaaatggaa atttgaaatt at                                            2782


<210>  6748
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  6748

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Thr Tyr Asn Tyr Leu Gly 
    210                 215                 220                 


Lys Lys Thr Asn Gln Met Leu Glu Ala Phe Glu Gln Lys Asp Phe Ser 
225                 230                 235                 240 


Leu Ala Leu Asn Tyr Gln Phe Cys Ile Gln Arg Phe Ile Asn Phe Val 
                245                 250                 255     


Val Lys Leu Gly Phe Gly Val Ser Gln Thr Lys Ala Ile Met Thr Leu 
            260                 265                 270         


Val Ser Gly Ile Pro Met Gly Pro Pro Arg Leu Pro Leu Gln Lys Ala 
        275                 280                 285             


Ser Arg Glu Phe Thr Asp Ser Ala Glu Ala Lys Leu Lys Ser Leu Asp 
    290                 295                 300                 


Phe Leu Ser Phe Thr Asp Leu Lys Asp Gly Asn Leu Glu Ala Gly Ser 
305                 310                 315                 320 


<210>  6749
<211>  1903
<212>  DNA
<213>  Homosapiens

<400>  6749
gggcagttgg gattctccgt acgcctcgga aacagcagcc caaacctcac aacgcagaac     60

cacgagatag tggggattgc agagccctgc gcaagagaag gaaaattaag acgcagcgga    120

gcccaggagg tgcccgcacg cgggaaggac tggcgtgcag acgaggcagg gggaggtttg    180

cactcggcgt ggcgcgggtg agccgcgtgc tctcgggcac ccggccgcca gttcggatgc    240

ttccgatcct cggggagccg gggcgctgcg ccggagtcac ttcagcccat gttgttcagg    300

tgacacccgg ggaagagcag actccagtgt gcaaaacgtt tcggggtttc cgggccagcg    360

gttccgggcg cgcctcgcgg gcggcggcgc agaactacaa cccccaggct ccctggcgtg    420

gcggcacgtg ggcccgagcc gggcggccgc ggatataaag cgcggcggcg gctgccgggc    480

ggagcggctg cacggacaag agcggaggcc tggaagggga aactgaagca gaaagaggtt    540

acttaatggg ctcaaggtca cctacctgac ctaccagcag ctcaatggcc ttcccaaaga    600

agaaacttca gggtcttgtg gctgcaacca tcacgccaat gactgagaat ggagaaatca    660

acttttcagt aattggtcag tatgtggatt atcttgtgaa agaacaggga gtgaagaaca    720

tttttgtgaa tggcacaaca ggagaaggcc tgtccctgag cgtctcagag cgtcgccagg    780

ttgcagagga gtgggtgaca aaagggaagg acaagctgga tcaggtgata attcacgtag    840

gagcactgag cttgaaggag tcacaggaac tggcccaaca tgcagcagaa ataggagctg    900

atggcatcgc tgtcattgca ccgttcttcc tcaagccatg gaccaaagat atcctgatta    960

atttcctaaa ggaagtggct gctgccgccc ctgccctgcc attttattac tatcacattc   1020

ctgccttgac aggggtaaag attcgtgctg aggagttgtt ggatgggatt ctggataaga   1080

tccccacctt ccaagggctg aaattcagtg atacagatct cttagacttc gggcaatgtg   1140

ttgatcagaa tcgccagcaa cagtttgctt tcctttttgg ggtggatgag caactgttga   1200

gtgctctggt gatgggagca actggagcag tgggcagtac ctataactac ctgggaaaaa   1260

agacaaacca gatgttggag gcttttgaac aaaaggactt ctctttagcc ctgaactatc   1320

agttttgtat ccagagattt atcaactttg ttgtcaaact agaaaactca aaactcaaag   1380

tttcaaagaa ccaaaggact cttcctctgg gcaccacaaa cttccccttc ctccactgag   1440

aagactgtct ctcccgcagg accctgaatt attgaaatcg aaggctgact tcctttctgc   1500

agtgagccca ggggctaatg ttattatcct gtcacacttg caactagtga cttttgttta   1560

gtgatagaag atttggggag gacccaaagg actcagaact ttctctccat acctcctttt   1620

actcttttct ttctgtgtaa tgtatcaaca actgtttaat ctcccttcta acaaaccttg   1680

atataagctt tctgatatca aagtatattg acagttaacc cttactgatt ttaaacttga   1740

ctatccagtc tgttaattac ctaagatttt gttttcattt catctctaat tgttttgatc   1800

attggcagag aaagagtatt tgaaattcat atcagttttg ctccttattt taatctcttt   1860

gaattaaaaa taaaactttt tcaaaatgga aatttgaaat tat                     1903


<210>  6750
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  6750

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Thr Tyr Asn Tyr Leu Gly 
    210                 215                 220                 


Lys Lys Thr Asn Gln Met Leu Glu Ala Phe Glu Gln Lys Asp Phe Ser 
225                 230                 235                 240 


Leu Ala Leu Asn Tyr Gln Phe Cys Ile Gln Arg Phe Ile Asn Phe Val 
                245                 250                 255     


Val Lys Leu Glu Asn Ser Lys Leu Lys Val Ser Lys Asn Gln Arg Thr 
            260                 265                 270         


Leu Pro Leu Gly Thr Thr Asn Phe Pro Phe Leu His 
        275                 280                 


<210>  6751
<211>  1771
<212>  DNA
<213>  Homosapiens

<400>  6751
gggcagttgg gattctccgt acgcctcgga aacagcagcc caaacctcac aacgcagaac     60

cacgagatag tggggattgc agagccctgc gcaagagaag gaaaattaag acgcagcgga    120

gcccaggagg tgcccgcacg cgggaaggac tggcgtgcag acgaggcagg gggaggtttg    180

cactcggcgt ggcgcgggtg agccgcgtgc tctcgggcac ccggccgcca gttcggatgc    240

ttccgatcct cggggagccg gggcgctgcg ccggagtcac ttcagcccat gttgttcagg    300

tgacacccgg ggaagagcag actccagtgt gcaaaacgtt tcggggtttc cgggccagcg    360

gttccgggcg cgcctcgcgg gcggcggcgc agaactacaa cccccaggct ccctggcgtg    420

gcggcacgtg ggcccgagcc gggcggccgc ggatataaag cgcggcggcg gctgccgggc    480

ggagcggctg cacggacaag agcggaggcc tggaagggga aactgaagca gaaagaggtt    540

acttaatggg ctcaaggtca cctacctgac ctaccagcag ctcaatggcc ttcccaaaga    600

agaaacttca gggtcttgtg gctgcaacca tcacgccaat gactgagaat ggagaaatca    660

acttttcagt aattggtcag tatgtggatt atcttgtgaa agaacaggga gtgaagaaca    720

tttttgtgaa tggcacaaca ggagaaggcc tgtccctgag cgtctcagag cgtcgccagg    780

ttgcagagga gtgggtgaca aaagggaagg acaagctgga tcaggtgata attcacgtag    840

gagcactgag cttgaaggag tcacaggaac tggcccaaca tgcagcagaa ataggagctg    900

atggcatcgc tgtcattgca ccgttcttcc tcaagccatg gaccaaagat atcctgatta    960

atttcctaaa ggaagtggct gctgccgccc ctgccctgcc attttattac tatcacattc   1020

ctgccttgac aggggtaaag attcgtgctg aggagttgtt ggatgggatt ctggataaga   1080

tccccacctt ccaagggctg aaattcagtg atacagatct cttagacttc gggcaatgtg   1140

ttgatcagaa tcgccagcaa cagtttgctt tcctttttgg ggtggatgag ttttgtatcc   1200

agagatttat caactttgtt gtcaaactag aaaactcaaa actcaaagtt tcaaagaacc   1260

aaaggactct tcctctgggc accacaaact tccccttcct ccactgagaa gactgtctct   1320

cccgcaggac cctgaattat tgaaatcgaa ggctgacttc ctttctgcag tgagcccagg   1380

ggctaatgtt attatcctgt cacacttgca actagtgact tttgtttagt gatagaagat   1440

ttggggagga cccaaaggac tcagaacttt ctctccatac ctccttttac tcttttcttt   1500

ctgtgtaatg tatcaacaac tgtttaatct cccttctaac aaaccttgat ataagctttc   1560

tgatatcaaa gtatattgac agttaaccct tactgatttt aaacttgact atccagtctg   1620

ttaattacct aagattttgt tttcatttca tctctaattg ttttgatcat tggcagagaa   1680

agagtatttg aaattcatat cagttttgct ccttatttta atctctttga attaaaaata   1740

aaactttttc aaaatggaaa tttgaaatta t                                  1771


<210>  6752
<211>  240
<212>  PRT
<213>  Homosapiens

<400>  6752

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Phe Cys Ile Gln Arg Phe 
        195                 200                 205             


Ile Asn Phe Val Val Lys Leu Glu Asn Ser Lys Leu Lys Val Ser Lys 
    210                 215                 220                 


Asn Gln Arg Thr Leu Pro Leu Gly Thr Thr Asn Phe Pro Phe Leu His 
225                 230                 235                 240 


<210>  6753
<211>  2697
<212>  DNA
<213>  Homosapiens

<400>  6753
gggcagttgg gattctccgt acgcctcgga aacagcagcc caaacctcac aacgcagaac     60

cacgagatag tggggattgc agagccctgc gcaagagaag gaaaattaag acgcagcgga    120

gcccaggagg tgcccgcacg cgggaaggac tggcgtgcag acgaggcagg gggaggtttg    180

cactcggcgt ggcgcgggtg agccgcgtgc tctcgggcac ccggccgcca gttcggatgc    240

ttccgatcct cggggagccg gggcgctgcg ccggagtcac ttcagcccat gttgttcagg    300

tgacacccgg ggaagagcag actccagtgt gcaaaacgtt tcggggtttc cgggccagcg    360

gttccgggcg cgcctcgcgg gcggcggcgc agaactacaa cccccaggct ccctggcgtg    420

gcggcacgtg ggcccgagcc gggcggccgc ggatataaag cgcggcggcg gctgccgggc    480

ggagcggctg cacggacaag agcggaggcc tggaagggga aactgaagca gaaagaggtt    540

acttaatggg ctcaaggtca cctacctgac ctaccagcag ctcaatggcc ttcccaaaga    600

agaaacttca gggtcttgtg gctgcaacca tcacgccaat gactgagaat ggagaaatca    660

acttttcagt aattggtcag tatgtggatt atcttgtgaa agaacaggga gtgaagaaca    720

tttttgtgaa tggcacaaca ggagaaggcc tgtccctgag cgtctcagag cgtcgccagg    780

ttgcagagga gtgggtgaca aaagggaagg acaagctgga tcaggtgata attcacgtag    840

gagcactgag cttgaaggag tcacaggaac tggcccaaca tgcagcagaa ataggagctg    900

atggcatcgc tgtcattgca ccgttcttcc tcaagccatg gaccaaagat atcctgatta    960

atttcctaaa ggaagtggct gctgccgccc ctgccctgcc attttattac tatcacattc   1020

ctgccttgac aggggtaaag attcgtgctg aggagttgtt ggatgggatt ctggataaga   1080

tccccacctt ccaagggctg aaattcagtg atacagatct cttagacttc gggcaatgtg   1140

ttgatcagaa tcgccagcaa cagtttgctt tcctttttgg ggtggatgag caactgttga   1200

gtgctctggt gatgggagca actggagcag tgggcagttt tgtatccaga gatttatcaa   1260

ctttgttgtc aaactaggtt ttggagtgtc acagaccaaa gccatcatga ctctggtctc   1320

tgggattcca atgggcccac cccggcttcc actgcagaaa gcctccaggg agtttactga   1380

tagtgctgaa gctaaactga agagcctgga tttcctttct ttcactgatt taaaggatgg   1440

aaacttggaa gctggtagct agtgcctctc tatcaaatca gggtttgcac cttgagacat   1500

aatctacctt aaatagtgca tttttttctc agggaatttt agatgaactt gaataaactc   1560

tcctagcaaa tgaaatctca caataagcat tgaggtacct tttgtgagcc ttaaaaagtc   1620

ttattttgtg aaggggcaaa aactctagga gtcacaactc tcagtcattc atttcacaga   1680

tttttttgtg gagaaatttc tgtttatatg gatgaaatgg aatcaagagg aaaattgtaa   1740

ttgattaatt ccatctgtct ttaggagctc tcattatctc ggtctctggt tcctaatcct   1800

attttaaagt tgtctaattt taaaccacta taatatgtct tcattttaat aaatattcat   1860

ttggaatcta ggaaaactct gagctactgc atttaggcag gcactttaat accaaactgt   1920

aacatgtctc aactgtatac aactcaaaat acaccagctc atttggctgc tcagtctaac   1980

tctagaatgg atgcttttga attcatttcg atgtcaccac ttttcgctct ttaaaaacac   2040

tgggtcaggt gaggacttgt ttcagttcct ataactaagt aaagggcggc tttctcataa   2100

caaaggaaaa agtcttcccc aaagatgaat ttaagtctcc acttttttct atacagaaaa   2160

ctcaaaactc aaagtttcaa agaaccaaag gactcttcct ctgggcacca caaacttccc   2220

cttcctccac tgagaagact gtctctcccg caggaccctg aattattgaa atcgaaggct   2280

gacttccttt ctgcagtgag cccaggggct aatgttatta tcctgtcaca cttgcaacta   2340

gtgacttttg tttagtgata gaagatttgg ggaggaccca aaggactcag aactttctct   2400

ccatacctcc ttttactctt ttctttctgt gtaatgtatc aacaactgtt taatctccct   2460

tctaacaaac cttgatataa gctttctgat atcaaagtat attgacagtt aacccttact   2520

gattttaaac ttgactatcc agtctgttaa ttacctaaga ttttgttttc atttcatctc   2580

taattgtttt gatcattggc agagaaagag tatttgaaat tcatatcagt tttgctcctt   2640

attttaatct ctttgaatta aaaataaaac tttttcaaaa tggaaatttg aaattat      2697


<210>  6754
<211>  230
<212>  PRT
<213>  Homosapiens

<400>  6754

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Phe Val Ser Arg Asp Leu 
    210                 215                 220                 


Ser Thr Leu Leu Ser Asn 
225                 230 


<210>  6755
<211>  3023
<212>  DNA
<213>  Homosapiens

<400>  6755
gggcagttgg gattctccgt acgcctcgga aacagcagcc caaacctcac aacgcagaac     60

cacgagatag tggggattgc agagccctgc gcaagagaag gaaaattaag acgcagcgga    120

gcccaggagg tgcccgcacg cgggaaggac tggcgtgcag acgaggcagg gggaggtttg    180

cactcggcgt ggcgcgggtg agccgcgtgc tctcgggcac ccggccgcca gttcggatgc    240

ttccgatcct cggggagccg gggcgctgcg ccggagtcac ttcagcccat gttgttcagg    300

tgacacccgg ggaagagcag actccagtgt gcaaaacgtt tcggggtttc cgggccagcg    360

gttccgggcg cgcctcgcgg gcggcggcgc agaactacaa cccccaggct ccctggcgtg    420

gcggcacgtg ggcccgagcc gggcggccgc ggatataaag cgcggcggcg gctgccgggc    480

ggagcggctg cacggacaag agcggaggcc tggaagggga aactgaagca gaaagaggtt    540

acttaatggg ctcaaggtca cctacctgac ctaccagcag ctcaatggcc ttcccaaaga    600

agaaacttca gggtcttgtg gctgcaacca tcacgccaat gactgagaat ggagaaatca    660

acttttcagt aattggtcag tatgtggatt atcttgtgaa agaacaggga gtgaagaaca    720

tttttgtgaa tggcacaaca ggagaaggcc tgtccctgag cgtctcagag cgtcgccagg    780

ttgcagagga gtgggtgaca aaagggaagg acaagctgga tcaggtgata attcacgtag    840

gagcactgag cttgaaggag tcacaggaac tggcccaaca tgcagcagaa ataggagctg    900

atggcatcgc tgtcattgca ccgttcttcc tcaagccatg gaccaaagat atcctgatta    960

atttcctaaa ggaagtggct gctgccgccc ctgccctgcc attttattac tatcacattc   1020

ctgccttgac aggggtaaag attcgtgctg aggagttgtt ggatgggatt ctggataaga   1080

tccccacctt ccaagggctg aaattcagtg atacagatct cttagacttc gggcaatgtg   1140

ttgatcagaa tcgccagcaa cagtttgctt tcctttttgg ggtggatgag caactgttga   1200

gtgctctggt gatgggagca actggagcag tgggcagtac ctataactac ctgggaaaaa   1260

agacaaacca gatgttggag gcttttgaac aaaaggactt ctctttagcc ctgaactatc   1320

agttttgtat ccagagattt atcaactttg ttgtcaaact aggttttgga gtgtcacaga   1380

ccaaagccat catgactctg gtctctggga ttccaatggg cccaccccgg cttccactgc   1440

agaaagcctc cagggagttt actgatagtg ctgaagctaa actgaagagc ctggatttcc   1500

tttctttcac tgatttaaag gatggaaact tggaagctgg tagctagtgc ctctctatca   1560

aatcagggtt tgcaccttga gacataatct accttaaata gtgcattttt ttctcaggga   1620

attttagatg aacttgaata aactctccta gcaaatgaaa tctcacaata agcattgagg   1680

taccttttgt gagccttaaa aagtcttatt ttgtgaaggg gcaaaaactc taggagtcac   1740

aactctcagt cattcatttc acagattttt ttgtggagaa atttctgttt atatggatga   1800

aatggaatca agaggaaaat tgtaattgat taattccatc tgtctttagg agctctcatt   1860

atctcggtct ctggttccta atcctatttt aaagttgtct aattttaaac cactataata   1920

tgtcttcatt ttaataaata ttcatttgga atctaggaaa actctgagct actgcattta   1980

ggcaggcact ttaataccaa actgtaacat gtctcaactg tatacaactc aaaatacacc   2040

agctcatttg gctgctcagt ctaactctag aatggatgct tttgaattca tttcgatgtc   2100

accacttttc gctctttaaa aacactgggt caggtgagga cttgtttcag ttcctataac   2160

taagtaaagg gcggctttct cataacaaag gaaaaagtct tccccaaaga tgaatttaag   2220

tctccacttt tttctataca gaaaactcaa aactcaaagt ttcaaagaac caaaggactc   2280

ttcctctggg caccacaaac ttccccttcc tccactgaga agactgtctc tcccgcagga   2340

ccctgaatta ttgaaatcga aggctgactt cctttctgca gtgagcccag gggctaatgt   2400

tattatcctg tcacacttgc aactagtgac ttttgtttag tgatagaaga tttggggagg   2460

acccaaagga ctcagaactt tctctccata cctcctttta ctcttttctt tctgtgtaat   2520

gtatcaacaa ctgtttaatc tcccttctaa caaaccttga tataagcttt ctgatatcaa   2580

agtatattga cagttaaccc ttactgattt taaacttgac tatccagtct gttaattacc   2640

taagattttg ttttcatttc atctctaatt gttttgatca ttggcagaga aagagtattt   2700

gaaattcata tcagttttgc tccttatttt aatctctttg aattaaaaat aaaacttttt   2760

caaaatggaa atttgaaatt ataagtagac ttcaattatc tttgctaatc ctctctttaa   2820

ttagtcagct agttaaaagt tgttatattc atatatcctc aaccctcttt ttgcctttgt   2880

agcttttaat ttcctgaaag aagaaaatga gttgttcgtt tttggttctg aggatgtgat   2940

atccgtactt actgatacta aagccaaatt taaattctaa aattaattct tgggtatcca   3000

ataaacaaag aactattttt cta                                           3023


<210>  6756
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  6756

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Thr Tyr Asn Tyr Leu Gly 
    210                 215                 220                 


Lys Lys Thr Asn Gln Met Leu Glu Ala Phe Glu Gln Lys Asp Phe Ser 
225                 230                 235                 240 


Leu Ala Leu Asn Tyr Gln Phe Cys Ile Gln Arg Phe Ile Asn Phe Val 
                245                 250                 255     


Val Lys Leu Gly Phe Gly Val Ser Gln Thr Lys Ala Ile Met Thr Leu 
            260                 265                 270         


Val Ser Gly Ile Pro Met Gly Pro Pro Arg Leu Pro Leu Gln Lys Ala 
        275                 280                 285             


Ser Arg Glu Phe Thr Asp Ser Ala Glu Ala Lys Leu Lys Ser Leu Asp 
    290                 295                 300                 


Phe Leu Ser Phe Thr Asp Leu Lys Asp Gly Asn Leu Glu Ala Gly Ser 
305                 310                 315                 320 


<210>  6757
<211>  2144
<212>  DNA
<213>  Homosapiens

<400>  6757
gggcagttgg gattctccgt acgcctcgga aacagcagcc caaacctcac aacgcagaac     60

cacgagatag tggggattgc agagccctgc gcaagagaag gaaaattaag acgcagcgga    120

gcccaggagg tgcccgcacg cgggaaggac tggcgtgcag acgaggcagg gggaggtttg    180

cactcggcgt ggcgcgggtg agccgcgtgc tctcgggcac ccggccgcca gttcggatgc    240

ttccgatcct cggggagccg gggcgctgcg ccggagtcac ttcagcccat gttgttcagg    300

tgacacccgg ggaagagcag actccagtgt gcaaaacgtt tcggggtttc cgggccagcg    360

gttccgggcg cgcctcgcgg gcggcggcgc agaactacaa cccccaggct ccctggcgtg    420

gcggcacgtg ggcccgagcc gggcggccgc ggatataaag cgcggcggcg gctgccgggc    480

ggagcggctg cacggacaag agcggaggcc tggaagggga aactgaagca gaaagaggtt    540

acttaatggg ctcaaggtca cctacctgac ctaccagcag ctcaatggcc ttcccaaaga    600

agaaacttca gggtcttgtg gctgcaacca tcacgccaat gactgagaat ggagaaatca    660

acttttcagt aattggtcag tatgtggatt atcttgtgaa agaacaggga gtgaagaaca    720

tttttgtgaa tggcacaaca ggagaaggcc tgtccctgag cgtctcagag cgtcgccagg    780

ttgcagagga gtgggtgaca aaagggaagg acaagctgga tcaggtgata attcacgtag    840

gagcactgag cttgaaggag tcacaggaac tggcccaaca tgcagcagaa ataggagctg    900

atggcatcgc tgtcattgca ccgttcttcc tcaagccatg gaccaaagat atcctgatta    960

atttcctaaa ggaagtggct gctgccgccc ctgccctgcc attttattac tatcacattc   1020

ctgccttgac aggggtaaag attcgtgctg aggagttgtt ggatgggatt ctggataaga   1080

tccccacctt ccaagggctg aaattcagtg atacagatct cttagacttc gggcaatgtg   1140

ttgatcagaa tcgccagcaa cagtttgctt tcctttttgg ggtggatgag caactgttga   1200

gtgctctggt gatgggagca actggagcag tgggcagtac ctataactac ctgggaaaaa   1260

agacaaacca gatgttggag gcttttgaac aaaaggactt ctctttagcc ctgaactatc   1320

agttttgtat ccagagattt atcaactttg ttgtcaaact agaaaactca aaactcaaag   1380

tttcaaagaa ccaaaggact cttcctctgg gcaccacaaa cttccccttc ctccactgag   1440

aagactgtct ctcccgcagg accctgaatt attgaaatcg aaggctgact tcctttctgc   1500

agtgagccca ggggctaatg ttattatcct gtcacacttg caactagtga cttttgttta   1560

gtgatagaag atttggggag gacccaaagg actcagaact ttctctccat acctcctttt   1620

actcttttct ttctgtgtaa tgtatcaaca actgtttaat ctcccttcta acaaaccttg   1680

atataagctt tctgatatca aagtatattg acagttaacc cttactgatt ttaaacttga   1740

ctatccagtc tgttaattac ctaagatttt gttttcattt catctctaat tgttttgatc   1800

attggcagag aaagagtatt tgaaattcat atcagttttg ctccttattt taatctcttt   1860

gaattaaaaa taaaactttt tcaaaatgga aatttgaaat tataagtaga cttcaattat   1920

ctttgctaat cctctcttta attagtcagc tagttaaaag ttgttatatt catatatcct   1980

caaccctctt tttgcctttg tagcttttaa tttcctgaaa gaagaaaatg agttgttcgt   2040

ttttggttct gaggatgtga tatccgtact tactgatact aaagccaaat ttaaattcta   2100

aaattaattc ttgggtatcc aataaacaaa gaactatttt tcta                    2144


<210>  6758
<211>  284
<212>  PRT
<213>  Homosapiens

<400>  6758

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Thr Tyr Asn Tyr Leu Gly 
    210                 215                 220                 


Lys Lys Thr Asn Gln Met Leu Glu Ala Phe Glu Gln Lys Asp Phe Ser 
225                 230                 235                 240 


Leu Ala Leu Asn Tyr Gln Phe Cys Ile Gln Arg Phe Ile Asn Phe Val 
                245                 250                 255     


Val Lys Leu Glu Asn Ser Lys Leu Lys Val Ser Lys Asn Gln Arg Thr 
            260                 265                 270         


Leu Pro Leu Gly Thr Thr Asn Phe Pro Phe Leu His 
        275                 280                 


<210>  6759
<211>  2938
<212>  DNA
<213>  Homosapiens

<400>  6759
gggcagttgg gattctccgt acgcctcgga aacagcagcc caaacctcac aacgcagaac     60

cacgagatag tggggattgc agagccctgc gcaagagaag gaaaattaag acgcagcgga    120

gcccaggagg tgcccgcacg cgggaaggac tggcgtgcag acgaggcagg gggaggtttg    180

cactcggcgt ggcgcgggtg agccgcgtgc tctcgggcac ccggccgcca gttcggatgc    240

ttccgatcct cggggagccg gggcgctgcg ccggagtcac ttcagcccat gttgttcagg    300

tgacacccgg ggaagagcag actccagtgt gcaaaacgtt tcggggtttc cgggccagcg    360

gttccgggcg cgcctcgcgg gcggcggcgc agaactacaa cccccaggct ccctggcgtg    420

gcggcacgtg ggcccgagcc gggcggccgc ggatataaag cgcggcggcg gctgccgggc    480

ggagcggctg cacggacaag agcggaggcc tggaagggga aactgaagca gaaagaggtt    540

acttaatggg ctcaaggtca cctacctgac ctaccagcag ctcaatggcc ttcccaaaga    600

agaaacttca gggtcttgtg gctgcaacca tcacgccaat gactgagaat ggagaaatca    660

acttttcagt aattggtcag tatgtggatt atcttgtgaa agaacaggga gtgaagaaca    720

tttttgtgaa tggcacaaca ggagaaggcc tgtccctgag cgtctcagag cgtcgccagg    780

ttgcagagga gtgggtgaca aaagggaagg acaagctgga tcaggtgata attcacgtag    840

gagcactgag cttgaaggag tcacaggaac tggcccaaca tgcagcagaa ataggagctg    900

atggcatcgc tgtcattgca ccgttcttcc tcaagccatg gaccaaagat atcctgatta    960

atttcctaaa ggaagtggct gctgccgccc ctgccctgcc attttattac tatcacattc   1020

ctgccttgac aggggtaaag attcgtgctg aggagttgtt ggatgggatt ctggataaga   1080

tccccacctt ccaagggctg aaattcagtg atacagatct cttagacttc gggcaatgtg   1140

ttgatcagaa tcgccagcaa cagtttgctt tcctttttgg ggtggatgag caactgttga   1200

gtgctctggt gatgggagca actggagcag tgggcagttt tgtatccaga gatttatcaa   1260

ctttgttgtc aaactaggtt ttggagtgtc acagaccaaa gccatcatga ctctggtctc   1320

tgggattcca atgggcccac cccggcttcc actgcagaaa gcctccaggg agtttactga   1380

tagtgctgaa gctaaactga agagcctgga tttcctttct ttcactgatt taaaggatgg   1440

aaacttggaa gctggtagct agtgcctctc tatcaaatca gggtttgcac cttgagacat   1500

aatctacctt aaatagtgca tttttttctc agggaatttt agatgaactt gaataaactc   1560

tcctagcaaa tgaaatctca caataagcat tgaggtacct tttgtgagcc ttaaaaagtc   1620

ttattttgtg aaggggcaaa aactctagga gtcacaactc tcagtcattc atttcacaga   1680

tttttttgtg gagaaatttc tgtttatatg gatgaaatgg aatcaagagg aaaattgtaa   1740

ttgattaatt ccatctgtct ttaggagctc tcattatctc ggtctctggt tcctaatcct   1800

attttaaagt tgtctaattt taaaccacta taatatgtct tcattttaat aaatattcat   1860

ttggaatcta ggaaaactct gagctactgc atttaggcag gcactttaat accaaactgt   1920

aacatgtctc aactgtatac aactcaaaat acaccagctc atttggctgc tcagtctaac   1980

tctagaatgg atgcttttga attcatttcg atgtcaccac ttttcgctct ttaaaaacac   2040

tgggtcaggt gaggacttgt ttcagttcct ataactaagt aaagggcggc tttctcataa   2100

caaaggaaaa agtcttcccc aaagatgaat ttaagtctcc acttttttct atacagaaaa   2160

ctcaaaactc aaagtttcaa agaaccaaag gactcttcct ctgggcacca caaacttccc   2220

cttcctccac tgagaagact gtctctcccg caggaccctg aattattgaa atcgaaggct   2280

gacttccttt ctgcagtgag cccaggggct aatgttatta tcctgtcaca cttgcaacta   2340

gtgacttttg tttagtgata gaagatttgg ggaggaccca aaggactcag aactttctct   2400

ccatacctcc ttttactctt ttctttctgt gtaatgtatc aacaactgtt taatctccct   2460

tctaacaaac cttgatataa gctttctgat atcaaagtat attgacagtt aacccttact   2520

gattttaaac ttgactatcc agtctgttaa ttacctaaga ttttgttttc atttcatctc   2580

taattgtttt gatcattggc agagaaagag tatttgaaat tcatatcagt tttgctcctt   2640

attttaatct ctttgaatta aaaataaaac tttttcaaaa tggaaatttg aaattataag   2700

tagacttcaa ttatctttgc taatcctctc tttaattagt cagctagtta aaagttgtta   2760

tattcatata tcctcaaccc tctttttgcc tttgtagctt ttaatttcct gaaagaagaa   2820

aatgagttgt tcgtttttgg ttctgaggat gtgatatccg tacttactga tactaaagcc   2880

aaatttaaat tctaaaatta attcttgggt atccaataaa caaagaacta tttttcta     2938


<210>  6760
<211>  230
<212>  PRT
<213>  Homosapiens

<400>  6760

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Phe Val Ser Arg Asp Leu 
    210                 215                 220                 


Ser Thr Leu Leu Ser Asn 
225                 230 


<210>  6761
<211>  2392
<212>  DNA
<213>  Homosapiens

<400>  6761
gccgggcgga gcggctgcac ggacaagagc ggaggcctgg ctatacctgc tggaatggat     60

aaagtgagct ttaaaagttg atcagaccga agagattgaa gtgagagaac cacaggaaca    120

aagaagggga aactgaagca gaaagaggtt acttaatggg ctcaaggtca cctacctgac    180

ctaccagcag ctcaatggcc ttcccaaaga agaaacttca gggtcttgtg gctgcaacca    240

tcacgccaat gactgagaat ggagaaatca acttttcagt aattggtcag tatgtggatt    300

atcttgtgaa agaacaggga gtgaagaaca tttttgtgaa tggcacaaca ggagaaggcc    360

tgtccctgag cgtctcagag cgtcgccagg ttgcagagga gtgggtgaca aaagggaagg    420

acaagctgga tcaggtgata attcacgtag gagcactgag cttgaaggag tcacaggaac    480

tggcccaaca tgcagcagaa ataggagctg atggcatcgc tgtcattgca ccgttcttcc    540

tcaagccatg gaccaaagat atcctgatta atttcctaaa ggaagtggct gctgccgccc    600

ctgccctgcc attttattac tatcacattc ctgccttgac aggggtaaag attcgtgctg    660

aggagttgtt ggatgggatt ctggataaga tccccacctt ccaagggctg aaattcagtg    720

atacagatct cttagacttc gggcaatgtg ttgatcagaa tcgccagcaa cagtttgctt    780

tcctttttgg ggtggatgag caactgttga gtgctctggt gatgggagca actggagcag    840

tgggcagtac ctataactac ctgggaaaaa agacaaacca gatgttggag gcttttgaac    900

aaaaggactt ctctttagcc ctgaactatc agttttgtat ccagagattt atcaactttg    960

ttgtcaaact aggttttgga gtgtcacaga ccaaagccat catgactctg gtctctggga   1020

ttccaatggg cccaccccgg cttccactgc agaaagcctc cagggagttt actgatagtg   1080

ctgaagctaa actgaagagc ctggatttcc tttctttcac tgatttaaag gatggaaact   1140

tggaagctgg tagctagtgc ctctctatca aatcagggtt tgcaccttga gacataatct   1200

accttaaata gtgcattttt ttctcaggga attttagatg aacttgaata aactctccta   1260

gcaaatgaaa tctcacaata agcattgagg taccttttgt gagccttaaa aagtcttatt   1320

ttgtgaaggg gcaaaaactc taggagtcac aactctcagt cattcatttc acagattttt   1380

ttgtggagaa atttctgttt atatggatga aatggaatca agaggaaaat tgtaattgat   1440

taattccatc tgtctttagg agctctcatt atctcggtct ctggttccta atcctatttt   1500

aaagttgtct aattttaaac cactataata tgtcttcatt ttaataaata ttcatttgga   1560

atctaggaaa actctgagct actgcattta ggcaggcact ttaataccaa actgtaacat   1620

gtctcaactg tatacaactc aaaatacacc agctcatttg gctgctcagt ctaactctag   1680

aatggatgct tttgaattca tttcgatgtc accacttttc gctctttaaa aacactgggt   1740

caggtgagga cttgtttcag ttcctataac taagtaaagg gcggctttct cataacaaag   1800

gaaaaagtct tccccaaaga tgaatttaag tctccacttt tttctataca gaaaactcaa   1860

aactcaaagt ttcaaagaac caaaggactc ttcctctggg caccacaaac ttccccttcc   1920

tccactgaga agactgtctc tcccgcagga ccctgaatta ttgaaatcga aggctgactt   1980

cctttctgca gtgagcccag gggctaatgt tattatcctg tcacacttgc aactagtgac   2040

ttttgtttag tgatagaaga tttggggagg acccaaagga ctcagaactt tctctccata   2100

cctcctttta ctcttttctt tctgtgtaat gtatcaacaa ctgtttaatc tcccttctaa   2160

caaaccttga tataagcttt ctgatatcaa agtatattga cagttaaccc ttactgattt   2220

taaacttgac tatccagtct gttaattacc taagattttg ttttcatttc atctctaatt   2280

gttttgatca ttggcagaga aagagtattt gaaattcata tcagttttgc tccttatttt   2340

aatctctttg aattaaaaat aaaacttttt caaaatggaa atttgaaatt at           2392


<210>  6762
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  6762

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Thr Tyr Asn Tyr Leu Gly 
    210                 215                 220                 


Lys Lys Thr Asn Gln Met Leu Glu Ala Phe Glu Gln Lys Asp Phe Ser 
225                 230                 235                 240 


Leu Ala Leu Asn Tyr Gln Phe Cys Ile Gln Arg Phe Ile Asn Phe Val 
                245                 250                 255     


Val Lys Leu Gly Phe Gly Val Ser Gln Thr Lys Ala Ile Met Thr Leu 
            260                 265                 270         


Val Ser Gly Ile Pro Met Gly Pro Pro Arg Leu Pro Leu Gln Lys Ala 
        275                 280                 285             


Ser Arg Glu Phe Thr Asp Ser Ala Glu Ala Lys Leu Lys Ser Leu Asp 
    290                 295                 300                 


Phe Leu Ser Phe Thr Asp Leu Lys Asp Gly Asn Leu Glu Ala Gly Ser 
305                 310                 315                 320 


<210>  6763
<211>  2633
<212>  DNA
<213>  Homosapiens

<400>  6763
gccgggcgga gcggctgcac ggacaagagc ggaggcctgg ctatacctgc tggaatggat     60

aaagtgagct ttaaaagttg atcagaccga agagattgaa gtgagagaac cacaggaaca    120

aagaagggga aactgaagca gaaagaggtt acttaatggg ctcaaggtca cctacctgac    180

ctaccagcag ctcaatggcc ttcccaaaga agaaacttca gggtcttgtg gctgcaacca    240

tcacgccaat gactgagaat ggagaaatca acttttcagt aattggtcag tatgtggatt    300

atcttgtgaa agaacaggga gtgaagaaca tttttgtgaa tggcacaaca ggagaaggcc    360

tgtccctgag cgtctcagag cgtcgccagg ttgcagagga gtgggtgaca aaagggaagg    420

acaagctgga tcaggtgata attcacgtag gagcactgag cttgaaggag tcacaggaac    480

tggcccaaca tgcagcagaa ataggagctg atggcatcgc tgtcattgca ccgttcttcc    540

tcaagccatg gaccaaagat atcctgatta atttcctaaa ggaagtggct gctgccgccc    600

ctgccctgcc attttattac tatcacattc ctgccttgac aggggtaaag attcgtgctg    660

aggagttgtt ggatgggatt ctggataaga tccccacctt ccaagggctg aaattcagtg    720

atacagatct cttagacttc gggcaatgtg ttgatcagaa tcgccagcaa cagtttgctt    780

tcctttttgg ggtggatgag caactgttga gtgctctggt gatgggagca actggagcag    840

tgggcagtac ctataactac ctgggaaaaa agacaaacca gatgttggag gcttttgaac    900

aaaaggactt ctctttagcc ctgaactatc agttttgtat ccagagattt atcaactttg    960

ttgtcaaact aggttttgga gtgtcacaga ccaaagccat catgactctg gtctctggga   1020

ttccaatggg cccaccccgg cttccactgc agaaagcctc cagggagttt actgatagtg   1080

ctgaagctaa actgaagagc ctggatttcc tttctttcac tgatttaaag gatggaaact   1140

tggaagctgg tagctagtgc ctctctatca aatcagggtt tgcaccttga gacataatct   1200

accttaaata gtgcattttt ttctcaggga attttagatg aacttgaata aactctccta   1260

gcaaatgaaa tctcacaata agcattgagg taccttttgt gagccttaaa aagtcttatt   1320

ttgtgaaggg gcaaaaactc taggagtcac aactctcagt cattcatttc acagattttt   1380

ttgtggagaa atttctgttt atatggatga aatggaatca agaggaaaat tgtaattgat   1440

taattccatc tgtctttagg agctctcatt atctcggtct ctggttccta atcctatttt   1500

aaagttgtct aattttaaac cactataata tgtcttcatt ttaataaata ttcatttgga   1560

atctaggaaa actctgagct actgcattta ggcaggcact ttaataccaa actgtaacat   1620

gtctcaactg tatacaactc aaaatacacc agctcatttg gctgctcagt ctaactctag   1680

aatggatgct tttgaattca tttcgatgtc accacttttc gctctttaaa aacactgggt   1740

caggtgagga cttgtttcag ttcctataac taagtaaagg gcggctttct cataacaaag   1800

gaaaaagtct tccccaaaga tgaatttaag tctccacttt tttctataca gaaaactcaa   1860

aactcaaagt ttcaaagaac caaaggactc ttcctctggg caccacaaac ttccccttcc   1920

tccactgaga agactgtctc tcccgcagga ccctgaatta ttgaaatcga aggctgactt   1980

cctttctgca gtgagcccag gggctaatgt tattatcctg tcacacttgc aactagtgac   2040

ttttgtttag tgatagaaga tttggggagg acccaaagga ctcagaactt tctctccata   2100

cctcctttta ctcttttctt tctgtgtaat gtatcaacaa ctgtttaatc tcccttctaa   2160

caaaccttga tataagcttt ctgatatcaa agtatattga cagttaaccc ttactgattt   2220

taaacttgac tatccagtct gttaattacc taagattttg ttttcatttc atctctaatt   2280

gttttgatca ttggcagaga aagagtattt gaaattcata tcagttttgc tccttatttt   2340

aatctctttg aattaaaaat aaaacttttt caaaatggaa atttgaaatt ataagtagac   2400

ttcaattatc tttgctaatc ctctctttaa ttagtcagct agttaaaagt tgttatattc   2460

atatatcctc aaccctcttt ttgcctttgt agcttttaat ttcctgaaag aagaaaatga   2520

gttgttcgtt tttggttctg aggatgtgat atccgtactt actgatacta aagccaaatt   2580

taaattctaa aattaattct tgggtatcca ataaacaaag aactattttt cta          2633


<210>  6764
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  6764

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Thr Tyr Asn Tyr Leu Gly 
    210                 215                 220                 


Lys Lys Thr Asn Gln Met Leu Glu Ala Phe Glu Gln Lys Asp Phe Ser 
225                 230                 235                 240 


Leu Ala Leu Asn Tyr Gln Phe Cys Ile Gln Arg Phe Ile Asn Phe Val 
                245                 250                 255     


Val Lys Leu Gly Phe Gly Val Ser Gln Thr Lys Ala Ile Met Thr Leu 
            260                 265                 270         


Val Ser Gly Ile Pro Met Gly Pro Pro Arg Leu Pro Leu Gln Lys Ala 
        275                 280                 285             


Ser Arg Glu Phe Thr Asp Ser Ala Glu Ala Lys Leu Lys Ser Leu Asp 
    290                 295                 300                 


Phe Leu Ser Phe Thr Asp Leu Lys Asp Gly Asn Leu Glu Ala Gly Ser 
305                 310                 315                 320 


<210>  6765
<211>  695
<212>  DNA
<213>  Homosapiens

<400>  6765
ggacaagagc ggaggcctgg gtgagcgcgg cccgcgacgg cacgggctag gacagacgga     60

cgcagacggc ccgacgacct gggcgttcgg gcggaggggc gctggggcct gactcgcgga    120

aggggaaact gaagcagaaa gaggttactt aatgggctca aggtcaccta cctgacctac    180

cagcagctca atggccttcc caaagaagaa acttcagggt cttgtggctg caaccatcac    240

gccaatgact gagaatggtt ttaagaaaga ctggcatcag ctgtttctca atgcatcagt    300

cacttgttcg cagatcaaac agaagacatg tgattgcatg aatcggcagg atttacttcc    360

tgttacagag tgagatcctt tctgtaatct cctaacactg catctggtcc atactacttt    420

aaccttttaa taagacccct cttatcctgg aagtggcttc ttaaaacagt cttgtttgtt    480

catcagggac ccacggacaa tgtcagtgtg ttcttcctcc ctgttttgcc gttttcctgg    540

aaggccagat cccatgatag agataactaa aatgactttt tctggatctt tttccgtttc    600

ccaaaaatct gtggtcctgc tgcatccatt ttactatttt ctcatcaatt ctgcgttttt    660

cttctaggaa ccttactttc ctaaggtgtg aaatc                               695


<210>  6766
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  6766

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Phe Lys Lys Asp Trp His Gln Leu Phe 
            20                  25                  30          


Leu Asn Ala Ser Val Thr Cys Ser Gln Ile Lys Gln Lys Thr Cys Asp 
        35                  40                  45              


Cys Met Asn Arg Gln Asp Leu Leu Pro Val Thr Glu 
    50                  55                  60  


<210>  6767
<211>  2388
<212>  DNA
<213>  Homosapiens

<400>  6767
ggacaagagc ggaggcctgg gtgagcgcgg cccgcgacgg cacgggctag gacagacgga     60

cgcagacggc ccgacgacct gggcgttcgg gcggaggggc gctggggcct gactcgcgga    120

aggggaaact gaagcagaaa gaggttactt aatgggctca aggtcaccta cctgacctac    180

cagcagctca atggccttcc caaagaagaa acttcagggt cttgtggctg caaccatcac    240

gccaatgact gagaatggag aaatcaactt ttcagtaatt ggtcagtatg tggattatct    300

tgtgaaagaa cagggagtga agaacatttt tgtgaatggc acaacaggag aaggcctgtc    360

cctgagcgtc tcagagcgtc gccaggttgc agaggagtgg gtgacaaaag ggaaggacaa    420

gctggatcag gtgataattc acgtaggagc actgagcttg aaggagtcac aggaactggc    480

ccaacatgca gcagaaatag gagctgatgg catcgctgtc attgcaccgt tcttcctcaa    540

gccatggacc aaagatatcc tgattaattt cctaaaggaa gtggctgctg ccgcccctgc    600

cctgccattt tattactatc acattcctgc cttgacaggg gtaaagattc gtgctgagga    660

gttgttggat gggattctgg ataagatccc caccttccaa gggctgaaat tcagtgatac    720

agatctctta gacttcgggc aatgtgttga tcagaatcgc cagcaacagt ttgctttcct    780

ttttggggtg gatgagcaac tgttgagtgc tctggtgatg ggagcaactg gagcagtggg    840

cagtacctat aactacctgg gaaaaaagac aaaccagatg ttggaggctt ttgaacaaaa    900

ggacttctct ttagccctga actatcagtt ttgtatccag agatttatca actttgttgt    960

caaactaggt tttggagtgt cacagaccaa agccatcatg actctggtct ctgggattcc   1020

aatgggccca ccccggcttc cactgcagaa agcctccagg gagtttactg atagtgctga   1080

agctaaactg aagagcctgg atttcctttc tttcactgat ttaaaggatg gaaacttgga   1140

agctggtagc tagtgcctct ctatcaaatc agggtttgca ccttgagaca taatctacct   1200

taaatagtgc atttttttct cagggaattt tagatgaact tgaataaact ctcctagcaa   1260

atgaaatctc acaataagca ttgaggtacc ttttgtgagc cttaaaaagt cttattttgt   1320

gaaggggcaa aaactctagg agtcacaact ctcagtcatt catttcacag atttttttgt   1380

ggagaaattt ctgtttatat ggatgaaatg gaatcaagag gaaaattgta attgattaat   1440

tccatctgtc tttaggagct ctcattatct cggtctctgg ttcctaatcc tattttaaag   1500

ttgtctaatt ttaaaccact ataatatgtc ttcattttaa taaatattca tttggaatct   1560

aggaaaactc tgagctactg catttaggca ggcactttaa taccaaactg taacatgtct   1620

caactgtata caactcaaaa tacaccagct catttggctg ctcagtctaa ctctagaatg   1680

gatgcttttg aattcatttc gatgtcacca cttttcgctc tttaaaaaca ctgggtcagg   1740

tgaggacttg tttcagttcc tataactaag taaagggcgg ctttctcata acaaaggaaa   1800

aagtcttccc caaagatgaa tttaagtctc cacttttttc tatacagaaa actcaaaact   1860

caaagtttca aagaaccaaa ggactcttcc tctgggcacc acaaacttcc ccttcctcca   1920

ctgagaagac tgtctctccc gcaggaccct gaattattga aatcgaaggc tgacttcctt   1980

tctgcagtga gcccaggggc taatgttatt atcctgtcac acttgcaact agtgactttt   2040

gtttagtgat agaagatttg gggaggaccc aaaggactca gaactttctc tccatacctc   2100

cttttactct tttctttctg tgtaatgtat caacaactgt ttaatctccc ttctaacaaa   2160

ccttgatata agctttctga tatcaaagta tattgacagt taacccttac tgattttaaa   2220

cttgactatc cagtctgtta attacctaag attttgtttt catttcatct ctaattgttt   2280

tgatcattgg cagagaaaga gtatttgaaa ttcatatcag ttttgctcct tattttaatc   2340

tctttgaatt aaaaataaaa ctttttcaaa atggaaattt gaaattat                2388


<210>  6768
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  6768

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Thr Tyr Asn Tyr Leu Gly 
    210                 215                 220                 


Lys Lys Thr Asn Gln Met Leu Glu Ala Phe Glu Gln Lys Asp Phe Ser 
225                 230                 235                 240 


Leu Ala Leu Asn Tyr Gln Phe Cys Ile Gln Arg Phe Ile Asn Phe Val 
                245                 250                 255     


Val Lys Leu Gly Phe Gly Val Ser Gln Thr Lys Ala Ile Met Thr Leu 
            260                 265                 270         


Val Ser Gly Ile Pro Met Gly Pro Pro Arg Leu Pro Leu Gln Lys Ala 
        275                 280                 285             


Ser Arg Glu Phe Thr Asp Ser Ala Glu Ala Lys Leu Lys Ser Leu Asp 
    290                 295                 300                 


Phe Leu Ser Phe Thr Asp Leu Lys Asp Gly Asn Leu Glu Ala Gly Ser 
305                 310                 315                 320 


<210>  6769
<211>  2629
<212>  DNA
<213>  Homosapiens

<400>  6769
ggacaagagc ggaggcctgg gtgagcgcgg cccgcgacgg cacgggctag gacagacgga     60

cgcagacggc ccgacgacct gggcgttcgg gcggaggggc gctggggcct gactcgcgga    120

aggggaaact gaagcagaaa gaggttactt aatgggctca aggtcaccta cctgacctac    180

cagcagctca atggccttcc caaagaagaa acttcagggt cttgtggctg caaccatcac    240

gccaatgact gagaatggag aaatcaactt ttcagtaatt ggtcagtatg tggattatct    300

tgtgaaagaa cagggagtga agaacatttt tgtgaatggc acaacaggag aaggcctgtc    360

cctgagcgtc tcagagcgtc gccaggttgc agaggagtgg gtgacaaaag ggaaggacaa    420

gctggatcag gtgataattc acgtaggagc actgagcttg aaggagtcac aggaactggc    480

ccaacatgca gcagaaatag gagctgatgg catcgctgtc attgcaccgt tcttcctcaa    540

gccatggacc aaagatatcc tgattaattt cctaaaggaa gtggctgctg ccgcccctgc    600

cctgccattt tattactatc acattcctgc cttgacaggg gtaaagattc gtgctgagga    660

gttgttggat gggattctgg ataagatccc caccttccaa gggctgaaat tcagtgatac    720

agatctctta gacttcgggc aatgtgttga tcagaatcgc cagcaacagt ttgctttcct    780

ttttggggtg gatgagcaac tgttgagtgc tctggtgatg ggagcaactg gagcagtggg    840

cagtacctat aactacctgg gaaaaaagac aaaccagatg ttggaggctt ttgaacaaaa    900

ggacttctct ttagccctga actatcagtt ttgtatccag agatttatca actttgttgt    960

caaactaggt tttggagtgt cacagaccaa agccatcatg actctggtct ctgggattcc   1020

aatgggccca ccccggcttc cactgcagaa agcctccagg gagtttactg atagtgctga   1080

agctaaactg aagagcctgg atttcctttc tttcactgat ttaaaggatg gaaacttgga   1140

agctggtagc tagtgcctct ctatcaaatc agggtttgca ccttgagaca taatctacct   1200

taaatagtgc atttttttct cagggaattt tagatgaact tgaataaact ctcctagcaa   1260

atgaaatctc acaataagca ttgaggtacc ttttgtgagc cttaaaaagt cttattttgt   1320

gaaggggcaa aaactctagg agtcacaact ctcagtcatt catttcacag atttttttgt   1380

ggagaaattt ctgtttatat ggatgaaatg gaatcaagag gaaaattgta attgattaat   1440

tccatctgtc tttaggagct ctcattatct cggtctctgg ttcctaatcc tattttaaag   1500

ttgtctaatt ttaaaccact ataatatgtc ttcattttaa taaatattca tttggaatct   1560

aggaaaactc tgagctactg catttaggca ggcactttaa taccaaactg taacatgtct   1620

caactgtata caactcaaaa tacaccagct catttggctg ctcagtctaa ctctagaatg   1680

gatgcttttg aattcatttc gatgtcacca cttttcgctc tttaaaaaca ctgggtcagg   1740

tgaggacttg tttcagttcc tataactaag taaagggcgg ctttctcata acaaaggaaa   1800

aagtcttccc caaagatgaa tttaagtctc cacttttttc tatacagaaa actcaaaact   1860

caaagtttca aagaaccaaa ggactcttcc tctgggcacc acaaacttcc ccttcctcca   1920

ctgagaagac tgtctctccc gcaggaccct gaattattga aatcgaaggc tgacttcctt   1980

tctgcagtga gcccaggggc taatgttatt atcctgtcac acttgcaact agtgactttt   2040

gtttagtgat agaagatttg gggaggaccc aaaggactca gaactttctc tccatacctc   2100

cttttactct tttctttctg tgtaatgtat caacaactgt ttaatctccc ttctaacaaa   2160

ccttgatata agctttctga tatcaaagta tattgacagt taacccttac tgattttaaa   2220

cttgactatc cagtctgtta attacctaag attttgtttt catttcatct ctaattgttt   2280

tgatcattgg cagagaaaga gtatttgaaa ttcatatcag ttttgctcct tattttaatc   2340

tctttgaatt aaaaataaaa ctttttcaaa atggaaattt gaaattataa gtagacttca   2400

attatctttg ctaatcctct ctttaattag tcagctagtt aaaagttgtt atattcatat   2460

atcctcaacc ctctttttgc ctttgtagct tttaatttcc tgaaagaaga aaatgagttg   2520

ttcgtttttg gttctgagga tgtgatatcc gtacttactg atactaaagc caaatttaaa   2580

ttctaaaatt aattcttggg tatccaataa acaaagaact atttttcta               2629


<210>  6770
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  6770

Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile 
1               5                   10                  15      


Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln 
            20                  25                  30          


Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val 
        35                  40                  45              


Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg 
    50                  55                  60                  


Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln 
65                  70                  75                  80  


Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu 
                85                  90                  95      


Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala 
            100                 105                 110         


Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu 
        115                 120                 125             


Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His 
    130                 135                 140                 


Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp 
145                 150                 155                 160 


Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp 
                165                 170                 175     


Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln 
            180                 185                 190         


Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu 
        195                 200                 205             


Val Met Gly Ala Thr Gly Ala Val Gly Ser Thr Tyr Asn Tyr Leu Gly 
    210                 215                 220                 


Lys Lys Thr Asn Gln Met Leu Glu Ala Phe Glu Gln Lys Asp Phe Ser 
225                 230                 235                 240 


Leu Ala Leu Asn Tyr Gln Phe Cys Ile Gln Arg Phe Ile Asn Phe Val 
                245                 250                 255     


Val Lys Leu Gly Phe Gly Val Ser Gln Thr Lys Ala Ile Met Thr Leu 
            260                 265                 270         


Val Ser Gly Ile Pro Met Gly Pro Pro Arg Leu Pro Leu Gln Lys Ala 
        275                 280                 285             


Ser Arg Glu Phe Thr Asp Ser Ala Glu Ala Lys Leu Lys Ser Leu Asp 
    290                 295                 300                 


Phe Leu Ser Phe Thr Asp Leu Lys Asp Gly Asn Leu Glu Ala Gly Ser 
305                 310                 315                 320 


<210>  6771
<211>  503
<212>  DNA
<213>  Homosapiens

<400>  6771
ccttcccaaa gaagaaactt cagggtcttg tggctgcaac catcacgcca atgactgaga     60

atggttttaa gaaagactgg catcagctgt ttctcaatgc atcagtcact tgttcgcaga    120

tcaaacagaa gacatgtgat tgcatgaatc ggcaggattt acttcctgtt acagagtgag    180

atcctttctg taatctccta acactgcatc tggtccatac tactttaacc ttttaataag    240

acccctctta tcctggaagt ggcttcttaa aacagtcttg tttgttcatc agggacccac    300

ggacaatgtc agtgtgttct tcctccctgt tttgccgttt tcctggaagg ccagatccca    360

tgatagagat aactaaaatg actttttctg gatctttttc cgtttcccaa aaatctgtgg    420

tcctgctgca tccattttac tattttctca tcaattctgc gtttttcttc taggaacctt    480

actttcctaa ggtgtgaaat caa                                            503


<210>  6772
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  6772

Met Thr Glu Asn Gly Phe Lys Lys Asp Trp His Gln Leu Phe Leu Asn 
1               5                   10                  15      


Ala Ser Val Thr Cys Ser Gln Ile Lys Gln Lys Thr Cys Asp Cys Met 
            20                  25                  30          


Asn Arg Gln Asp Leu Leu Pro Val Thr Glu 
        35                  40          


<210>  6773
<211>  1217
<212>  DNA
<213>  Homosapiens

<400>  6773
agctatgtga gggagccata ggtatctctg tcctggcagt tgaagaaacg gagatcctaa     60

aggctagccc agctgcccca agccacacag ctagaaagag aaatcaactt ttcagtaatt    120

ggtcagtatg tggattatct tgtgaaagaa cagggagtga agaacatttt tgtgaatggc    180

acaacaggag aaggcctgtc cctgagcgtc tcagagcgtc gccaggttgc agaggagtgg    240

gtgacaaaag ggaaggacaa gctggatcag gtgataattc acgtaggagc actgagcttg    300

aaggagtcac aggaactggc ccaacatgca gcagaaatag gagctgatgg catcgctgtc    360

attgcaccgt tcttcctcaa gccatggacc aaagatatcc tgattaattt cctaaaggaa    420

gtggctgctg ccgcccctgc cctgccattt tattactatc acattcctgc cttgacaggg    480

gtaaagattc gtgctgagga gttgttggat gggattctgg ataagatccc caccttccaa    540

gggctgaaat tcagtgatac agatctctta gacttcgggc aatgtgttga tcagaatcgc    600

cagcaacagt ttgctttcct ttttggggtg gatgagtttt gtatccagag atttatcaac    660

tttgttgtca aactagaaaa ctcaaaactc aaagtttcaa agaaccaaag gactcttcct    720

ctgggcacca caaacttccc cttcctccac tgagaagact gtctctcccg caggaccctg    780

aattattgaa atcgaaggct gacttccttt ctgcagtgag cccaggggct aatgttatta    840

tcctgtcaca cttgcaacta gtgacttttg tttagtgata gaagatttgg ggaggaccca    900

aaggactcag aactttctct ccatacctcc ttttactctt ttctttctgt gtaatgtatc    960

aacaactgtt taatctccct tctaacaaac cttgatataa gctttctgat atcaaagtat   1020

attgacagtt aacccttact gattttaaac ttgactatcc agtctgttaa ttacctaaga   1080

ttttgttttc atttcatctc taattgtttt gatcattggc agagaaagag tatttgaaat   1140

tcatatcagt tttgctcctt attttaatct ctttgaatta aaaataaaac tttttcaaaa   1200

tggaaatttg aaattat                                                  1217


<210>  6774
<211>  230
<212>  PRT
<213>  Homosapiens

<400>  6774

Arg Leu Ala Gln Leu Pro Gln Ala Thr Gln Leu Glu Arg Glu Ile Asn 
1               5                   10                  15      


Phe Ser Val Ile Gly Gln Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly 
            20                  25                  30          


Val Lys Asn Ile Phe Val Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu 
        35                  40                  45              


Ser Val Ser Glu Arg Arg Gln Val Ala Glu Glu Trp Val Thr Lys Gly 
    50                  55                  60                  


Lys Asp Lys Leu Asp Gln Val Ile Ile His Val Gly Ala Leu Ser Leu 
65                  70                  75                  80  


Lys Glu Ser Gln Glu Leu Ala Gln His Ala Ala Glu Ile Gly Ala Asp 
                85                  90                  95      


Gly Ile Ala Val Ile Ala Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp 
            100                 105                 110         


Ile Leu Ile Asn Phe Leu Lys Glu Val Ala Ala Ala Ala Pro Ala Leu 
        115                 120                 125             


Pro Phe Tyr Tyr Tyr His Ile Pro Ala Leu Thr Gly Val Lys Ile Arg 
    130                 135                 140                 


Ala Glu Glu Leu Leu Asp Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln 
145                 150                 155                 160 


Gly Leu Lys Phe Ser Asp Thr Asp Leu Leu Asp Phe Gly Gln Cys Val 
                165                 170                 175     


Asp Gln Asn Arg Gln Gln Gln Phe Ala Phe Leu Phe Gly Val Asp Glu 
            180                 185                 190         


Phe Cys Ile Gln Arg Phe Ile Asn Phe Val Val Lys Leu Glu Asn Ser 
        195                 200                 205             


Lys Leu Lys Val Ser Lys Asn Gln Arg Thr Leu Pro Leu Gly Thr Thr 
    210                 215                 220                 


Asn Phe Pro Phe Leu His 
225                 230 


<210>  6775
<211>  1458
<212>  DNA
<213>  Homosapiens

<400>  6775
agctatgtga gggagccata ggtatctctg tcctggcagt tgaagaaacg gagatcctaa     60

aggctagccc agctgcccca agccacacag ctagaaagag aaatcaactt ttcagtaatt    120

ggtcagtatg tggattatct tgtgaaagaa cagggagtga agaacatttt tgtgaatggc    180

acaacaggag aaggcctgtc cctgagcgtc tcagagcgtc gccaggttgc agaggagtgg    240

gtgacaaaag ggaaggacaa gctggatcag gtgataattc acgtaggagc actgagcttg    300

aaggagtcac aggaactggc ccaacatgca gcagaaatag gagctgatgg catcgctgtc    360

attgcaccgt tcttcctcaa gccatggacc aaagatatcc tgattaattt cctaaaggaa    420

gtggctgctg ccgcccctgc cctgccattt tattactatc acattcctgc cttgacaggg    480

gtaaagattc gtgctgagga gttgttggat gggattctgg ataagatccc caccttccaa    540

gggctgaaat tcagtgatac agatctctta gacttcgggc aatgtgttga tcagaatcgc    600

cagcaacagt ttgctttcct ttttggggtg gatgagtttt gtatccagag atttatcaac    660

tttgttgtca aactagaaaa ctcaaaactc aaagtttcaa agaaccaaag gactcttcct    720

ctgggcacca caaacttccc cttcctccac tgagaagact gtctctcccg caggaccctg    780

aattattgaa atcgaaggct gacttccttt ctgcagtgag cccaggggct aatgttatta    840

tcctgtcaca cttgcaacta gtgacttttg tttagtgata gaagatttgg ggaggaccca    900

aaggactcag aactttctct ccatacctcc ttttactctt ttctttctgt gtaatgtatc    960

aacaactgtt taatctccct tctaacaaac cttgatataa gctttctgat atcaaagtat   1020

attgacagtt aacccttact gattttaaac ttgactatcc agtctgttaa ttacctaaga   1080

ttttgttttc atttcatctc taattgtttt gatcattggc agagaaagag tatttgaaat   1140

tcatatcagt tttgctcctt attttaatct ctttgaatta aaaataaaac tttttcaaaa   1200

tggaaatttg aaattataag tagacttcaa ttatctttgc taatcctctc tttaattagt   1260

cagctagtta aaagttgtta tattcatata tcctcaaccc tctttttgcc tttgtagctt   1320

ttaatttcct gaaagaagaa aatgagttgt tcgtttttgg ttctgaggat gtgatatccg   1380

tacttactga tactaaagcc aaatttaaat tctaaaatta attcttgggt atccaataaa   1440

caaagaacta tttttcta                                                 1458


<210>  6776
<211>  230
<212>  PRT
<213>  Homosapiens

<400>  6776

Arg Leu Ala Gln Leu Pro Gln Ala Thr Gln Leu Glu Arg Glu Ile Asn 
1               5                   10                  15      


Phe Ser Val Ile Gly Gln Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly 
            20                  25                  30          


Val Lys Asn Ile Phe Val Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu 
        35                  40                  45              


Ser Val Ser Glu Arg Arg Gln Val Ala Glu Glu Trp Val Thr Lys Gly 
    50                  55                  60                  


Lys Asp Lys Leu Asp Gln Val Ile Ile His Val Gly Ala Leu Ser Leu 
65                  70                  75                  80  


Lys Glu Ser Gln Glu Leu Ala Gln His Ala Ala Glu Ile Gly Ala Asp 
                85                  90                  95      


Gly Ile Ala Val Ile Ala Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp 
            100                 105                 110         


Ile Leu Ile Asn Phe Leu Lys Glu Val Ala Ala Ala Ala Pro Ala Leu 
        115                 120                 125             


Pro Phe Tyr Tyr Tyr His Ile Pro Ala Leu Thr Gly Val Lys Ile Arg 
    130                 135                 140                 


Ala Glu Glu Leu Leu Asp Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln 
145                 150                 155                 160 


Gly Leu Lys Phe Ser Asp Thr Asp Leu Leu Asp Phe Gly Gln Cys Val 
                165                 170                 175     


Asp Gln Asn Arg Gln Gln Gln Phe Ala Phe Leu Phe Gly Val Asp Glu 
            180                 185                 190         


Phe Cys Ile Gln Arg Phe Ile Asn Phe Val Val Lys Leu Glu Asn Ser 
        195                 200                 205             


Lys Leu Lys Val Ser Lys Asn Gln Arg Thr Leu Pro Leu Gly Thr Thr 
    210                 215                 220                 


Asn Phe Pro Phe Leu His 
225                 230 


<210>  6777
<211>  1096
<212>  DNA
<213>  Homosapiens

<400>  6777
ctagaaatgt tcccatcttt tgttttaatc ttaccctgtt gtagtagttg ctgttagcat     60

atgatctcct tctttgggat ttttgtggag agatagacgg taccagtcat gtttcctcat    120

ttgtttttcc cgtctaggtt ttggagtgtc acagaccaaa gccatcatga ctctggtctc    180

tgggattcca atgggcccac cccggcttcc actgcagaaa gcctccaggg agtttactga    240

tagtgctgaa gctaaactga agagcctgga tttcctttct ttcactgatt taaaggatgg    300

aaacttggaa gctgaaaact caaaactcaa agtttcaaag aaccaaagga ctcttcctct    360

gggcaccaca aacttcccct tcctccactg agaagactgt ctctcccgca ggaccctgaa    420

ttattgaaat cgaaggctga cttcctttct gcagtgagcc caggggctaa tgttattatc    480

ctgtcacact tgcaactagt gacttttgtt tagtgataga agatttgggg aggacccaaa    540

ggactcagaa ctttctctcc atacctcctt ttactctttt ctttctgtgt aatgtatcaa    600

caactgttta atctcccttc taacaaacct tgatataagc tttctgatat caaagtatat    660

tgacagttaa cccttactga ttttaaactt gactatccag tctgttaatt acctaagatt    720

ttgttttcat ttcatctcta attgttttga tcattggcag agaaagagta tttgaaattc    780

atatcagttt tgctccttat tttaatctct ttgaattaaa aataaaactt tttcaaaatg    840

gaaatttgaa attataagta gacttcaatt atctttgcta atcctctctt taattagtca    900

gctagttaaa agttgttata ttcatatatc ctcaaccctc tttttgcctt tgtagctttt    960

aatttcctga aagaagaaaa tgagttgttc gtttttggtt ctgaggatgt gatatccgta   1020

cttactgata ctaaagccaa atttaaattc taaaattaat tcttgggtat ccaataaaca   1080

aagaactatt tttcta                                                   1096


<210>  6778
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  6778

Met Thr Leu Val Ser Gly Ile Pro Met Gly Pro Pro Arg Leu Pro Leu 
1               5                   10                  15      


Gln Lys Ala Ser Arg Glu Phe Thr Asp Ser Ala Glu Ala Lys Leu Lys 
            20                  25                  30          


Ser Leu Asp Phe Leu Ser Phe Thr Asp Leu Lys Asp Gly Asn Leu Glu 
        35                  40                  45              


Ala Glu Asn Ser Lys Leu Lys Val Ser Lys Asn Gln Arg Thr Leu Pro 
    50                  55                  60                  


Leu Gly Thr Thr Asn Phe Pro Phe Leu His 
65                  70                  


<210>  6779
<211>  656
<212>  DNA
<213>  Homosapiens

<400>  6779
caatggtaag tttatttagg gcatctccat ttttttcaag cttttggaat cttttgcttt     60

caattactct taaatacagc aaatttatat tttgctacag gttccactct gagtcatttt    120

ttcttaatag attattacat cccatttacc tttattgaaa atctttctaa agtagtttgt    180

agagggaaac attaatttgt tcaggtaaat aaatacagta attctagtat ccaataagaa    240

attacaaatt ctagatatgt gaaactaatt aacactggaa aaaagtaaaa ccccataacc    300

ttatagaaat gtgttgttct tgtggtggct catgcctgta atccttggaa gctaaagatc    360

cagctttgaa aaatgtattt ccatgtaata tattgatact tttgttgtgc tcattatata    420

ctataaaaca cttgcaattc atttatgcta gttgagtctc tttatttatt tacttatttt    480

gagatggagt ctcactctgt cacccaggct ggagtgcagt gggacgatct gagctcgctg    540

caacttctgc ccctcctccc tccaggttca agcaattctc ctgcctcagc ctcccaagta    600

gctaggatta caggcacacg ccaccttgcc cggctaattt ttgtattttt agtaca        656


<210>  6780
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  6780

Met Leu Val Glu Ser Leu Tyr Leu Phe Thr Tyr Phe Glu Met Glu Ser 
1               5                   10                  15      


His Ser Val Thr Gln Ala Gly Val Gln Trp Asp Asp Leu Ser Ser Leu 
            20                  25                  30          


Gln Leu Leu Pro Leu Leu Pro Pro Gly Ser Ser Asn Ser Pro Ala Ser 
        35                  40                  45              


Ala Ser Gln Val Ala Arg Ile Thr Gly Thr Arg His Leu Ala Arg Leu 
    50                  55                  60                  


Ile Phe Val Phe Leu 
65                  


<210>  6781
<211>  1025
<212>  DNA
<213>  Homosapiens

<400>  6781
ggctcgtccc ttcccccacc cccagccgcc gccgccgccc gcgcttcgca acaaagccgg     60

ctgcggagcc atggtccacg gcgcccgccc gcgaccccgc cgccccgcat ggtagccgga    120

acgtctctcc cttaccagcc ttcgcttcct ggtgcccagc tcttaggacc gtgtgtgact    180

ctggccttct accgagacaa cagagaaacg cacagcaact cgcatggagg aatcggcgaa    240

atggctccga ccgcggcgct agggggcggg gccagcgagc ggtgttgaaa gcagcagggg    300

cctagaagac attaaaccga taccacagaa atacaaagga tcattagaga ctattatgaa    360

caactatatg ccaacaaatt ggaaaccaaa tggaaatgga taaattcctg aacagataca    420

acttaccaaa attggaccaa gaagaaatag aaaacctgaa aagaccaact atgagtaatg    480

agattaaatc agtaatatag agtctcccat caaagaaaag tccaggccct gatggcttca    540

ctgctgaatt ctactgaaca gttaaagaag aactcatacc agttctcaaa ctcatcctgt    600

gagggcagca ttaccctgat accaaaacta gatatggaca caagaaaaaa aatctatagg    660

ccagtatccc tgatgaacat agatgcaaga atcctcaaca agaccaggtg tggtggttca    720

tgcctgtaat cccagcactt tgggaggcca aggcaggtgg atcacctgag gtcaggaatt    780

tgagaccagc ctggccaaca tggcaaaacc ctgtctgtac taaaaataca aaaattagcc    840

gggcaaggtg gcgtgtgcct gtaatcctag ctacttggga ggctgaggca ggagaattgc    900

ttgaacctgg agggaggagg ggcagaagtt gcagcgagct cagatcgtcc cactgcactc    960

cagcctgggt gacagagtga gactccatct caaaataagt aaataaataa agagactcaa   1020

ctagc                                                               1025


<210>  6782
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  6782

Met Val Ala Gly Thr Ser Leu Pro Tyr Gln Pro Ser Leu Pro Gly Ala 
1               5                   10                  15      


Gln Leu Leu Gly Pro Cys Val Thr Leu Ala Phe Tyr Arg Asp Asn Arg 
            20                  25                  30          


Glu Thr His Ser Asn Ser His Gly Gly Ile Gly Glu Met Ala Pro Thr 
        35                  40                  45              


Ala Ala Leu Gly Gly Gly Ala Ser Glu Arg Cys 
    50                  55                  


<210>  6783
<211>  1917
<212>  DNA
<213>  Homosapiens

<400>  6783
agcgccgcgg tcggagccat ttcgccgatt cctccatgcg agttgctgtg cgtttctctg     60

ttgtctcggt agaaggccag agtcacacac ggtcctaaga gctgggcacc aggaagcgaa    120

ggctgatctg aagaagacac ttgaatcatg ggtgacgtta aaaattttct gtatgcctgg    180

tgtggcaaaa ggaagatgac cccatcctat gaaattagag cagtggggaa caaaaacagg    240

cagaaattca tgtgtgaggt tcaggtggaa ggttataatt acactggcat gggaaattcc    300

accaataaaa aagatgcaca aagcaatgct gccagagact ttgttaacta tttggttcga    360

ataaatgaaa taaagagtga agaagttcca gcttttgggg tagcatctcc gcccccactt    420

actgatactc ctgacactac agcaaatgct gaaggagatt taccaacaac catgggagga    480

cctcttcctc cacatctggc tctcaaagca gaaaataatt ctgaggtagg ggcctctggc    540

tatggtgttc ctgggcccac ctgggaccga ggagccaact tgaaggatta ctactcaaga    600

aaggaagaac aagaagtgca agcgactcta gaatcagaag aagtggattt aaatgctggg    660

cttcatggaa actggacctt ggaaaatgct aaagctcgtc taaaccaata ttttcagaaa    720

gaaaagatcc aaggagaata taagtacacc caagtgggtc ctgatcacaa caggagcttt    780

attgcagaaa tgaccattta tatcaagcag ctgggcagaa ggatttttgc acgagaacat    840

ggatcaaata agaaattggc agcacagtcc tgtgccctgt cacttgtcag acaactgtac    900

catcttggag tggttgaagc ttactccgga cttacaaaga agaaggaagg agagacagtg    960

gagccttaca aagtaaacct ctctcaagat ttagagcatc agctgcaaaa catcattcaa   1020

gagctaaatc ttgagatttt gcccccgcct gaagatcctt ctgtgccagt tgcactcaac   1080

attggcaaat tggctcagtt cgaaccatct cagcgacaaa accaagtggg tgtggttcct   1140

tggtcacctc cacaatccaa ctggaatcct tggactagta gcaacattga tgaggggcct   1200

ctggcttttg ctactccaga gcaaataagc atggacctca agaatgaatt gatgtaccag   1260

ttggaacagg atcatgattt gcaagcaatc ttgcaggaga gagagttact gcctgtgaag   1320

aaatttgaaa gtgagattct ggaagcaatc agccaaaatt cagttgtcat tattagaggg   1380

gctactggat gtgggaaaac cacacaggtt ccccagttca ttctagatga ctttatccag   1440

aatgaccgag cagcagagtg taacatcgta gtaactcagc ccagaagaat cagtgcggtt   1500

tctgtggcag agcgagttgc atttgaaaga ggagaagagc ctggaaaaag ctgtggctac   1560

agcgttcgat ttgagtctat acttcctcgt cctcatgcca gtataatgtt ttgtactgta   1620

ggtgtgctcc tgagaaaatt agaagcaggc attcgaggaa tcagtcatgt aattgtagat   1680

gaaatacatg aaagagatat taatactgac ttccttttgg tagtactgcg tgatgttgtt   1740

caggcttatc ctgaagttcg cattgttctt atgtctgcta ctattgatac cagcatgttt   1800

tgtgaatatt tcttcaattg ccccatcatt gaagtttatg ggaggactta cccagttcaa   1860

gaatattttc tggaagactg cattcagatg acccactttg ttcctccacc aaaagac      1917


<210>  6784
<211>  589
<212>  PRT
<213>  Homosapiens

<400>  6784

Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys 
1               5                   10                  15      


Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln 
            20                  25                  30          


Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met 
        35                  40                  45              


Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp 
    50                  55                  60                  


Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val 
65                  70                  75                  80  


Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp 
                85                  90                  95      


Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro 
            100                 105                 110         


Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly 
        115                 120                 125             


Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn 
    130                 135                 140                 


Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr 
145                 150                 155                 160 


Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp 
                165                 170                 175     


Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu 
            180                 185                 190         


Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn 
        195                 200                 205             


Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg 
    210                 215                 220                 


Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln 
225                 230                 235                 240 


Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val 
                245                 250                 255     


Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu 
            260                 265                 270         


Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn 
        275                 280                 285             


Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro 
    290                 295                 300                 


Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro 
305                 310                 315                 320 


Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln 
                325                 330                 335     


Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu 
            340                 345                 350         


Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu 
        355                 360                 365             


Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu 
    370                 375                 380                 


Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala 
385                 390                 395                 400 


Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly 
                405                 410                 415     


Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn 
            420                 425                 430         


Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile 
        435                 440                 445             


Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu 
    450                 455                 460                 


Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro 
465                 470                 475                 480 


Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg 
                485                 490                 495     


Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu 
            500                 505                 510         


Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg 
        515                 520                 525             


Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala 
    530                 535                 540                 


Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile 
545                 550                 555                 560 


Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu 
                565                 570                 575     


Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys 
            580                 585                 


<210>  6785
<211>  4173
<212>  DNA
<213>  Homosapiens

<400>  6785
agcgccgcgg tcggagccat ttcgccgatt cctccatgcg agttgctgtg cgtttctctg     60

ttgtctcggt agaaggccag agtcacacac ggtcctaaga gctgggcacc aggaagcgaa    120

ggctgatctg aagaagacac ttgaatcatg ggtgacgtta aaaattttct gtatgcctgg    180

tgtggcaaaa ggaagatgac cccatcctat gaaattagag cagtggggaa caaaaacagg    240

cagaaattca tgtgtgaggt tcaggtggaa ggttataatt acactggcat gggaaattcc    300

accaataaaa aagatgcaca aagcaatgct gccagagact ttgttaacta tttggttcga    360

ataaatgaaa taaagagtga agaagttcca gcttttgggg tagcatctcc gcccccactt    420

actgatactc ctgacactac agcaaatgct gaaggagatt taccaacaac catgggagga    480

cctcttcctc cacatctggc tctcaaagca gaaaataatt ctgaggtagg ggcctctggc    540

tatggtgttc ctgggcccac ctgggaccga ggagccaact tgaaggatta ctactcaaga    600

aaggaagaac aagaagtgca agcgactcta gaatcagaag aagtggattt aaatgctggg    660

cttcatggaa actggacctt ggaaaatgct aaagctcgtc taaaccaata ttttcagaaa    720

gaaaagatcc aaggagaata taagtacacc caagtgggtc ctgatcacaa caggagcttt    780

attgcagaaa tgaccattta tatcaagcag ctgggcagaa ggatttttgc acgagaacat    840

ggatcaaata agaaattggc agcacagtcc tgtgccctgt cacttgtcag acaactgtac    900

catcttggag tggttgaagc ttactccgga cttacaaaga agaaggaagg agagacagtg    960

gagccttaca aagtaaacct ctctcaagat ttagagcatc agctgcaaaa catcattcaa   1020

gagctaaatc ttgagatttt gcccccgcct gaagatcctt ctgtgccagt tgcactcaac   1080

attggcaaat tggctcagtt cgaaccatct cagcgacaaa accaagtggg tgtggttcct   1140

tggtcacctc cacaatccaa ctggaatcct tggactagta gcaacattga tgaggggcct   1200

ctggcttttg ctactccaga gcaaataagc atggacctca agaatgaatt gatgtaccag   1260

ttggaacagg atcatgattt gcaagcaatc ttgcaggaga gagagttact gcctgtgaag   1320

aaatttgaaa gtgagattct ggaagcaatc agccaaaatt cagttgtcat tattagaggg   1380

gctactggat gtgggaaaac cacacaggtt ccccagttca ttctagatga ctttatccag   1440

aatgaccgag cagcagagtg taacatcgta gtaactcagc ccagaagaat cagtgcggtt   1500

tctgtggcag agcgagttgc atttgaaaga ggagaagagc ctggaaaaag ctgtggctac   1560

agcgttcgat ttgagtctat acttcctcgt cctcatgcca gtataatgtt ttgtactgta   1620

ggtgtgctcc tgagaaaatt agaagcaggc attcgaggaa tcagtcatgt aattgtagat   1680

gaaatacatg aaagagatat taatactgac ttccttttgg tagtactgcg tgatgttgtt   1740

caggcttatc ctgaagttcg cattgttctt atgtctgcta ctattgatac cagcatgttt   1800

tgtgaatatt tcttcaattg ccccatcatt gaagtttatg ggaggactta cccagttcaa   1860

gaatattttc tggaagactg cattcagatg acccactttg ttcctccacc aaaagacaaa   1920

aagaagaagg ataaggatga tgatggtggt gaggatgatg atgcaaattg caacttgatc   1980

tgtggtgatg aatatggtcc agaaacaagg ttgagcatgt ctcaattgaa cgaaaaggaa   2040

actccttttg aactcatcga ggctctactt aagtacattg aaacccttaa tgttcctgga   2100

gctgtgttgg tttttttgcc tggctggaat ctgatttata ctatgcagaa gcatttggaa   2160

atgaatccac attttggaag ccatcggtat cagattctac ccctgcattc tcagattcct   2220

cgagaggaac agcgcaaagt gtttgatcca gtaccagttg gagtaaccaa ggttattttg   2280

tccacaaata ttgctgaaac aagcattacc ataaacgatg ttgtttatgt cattgactcc   2340

tgcaagcaga aagtgaaact cttcactgct cacaacaata tgaccaacta tgctaccgta   2400

tgggcatcaa aaacaaacct tgagcaacgg aaagggcgag ctggccgagt acggcctgga   2460

ttctgctttc acctgtgcag ccgagctcgt tttgagagac ttgaaaccca catgacacca   2520

gagatgttcc gaacaccatt gcatgaaatt gctcttagca taaaacttct gcgtctagga   2580

ggaattggcc aatttctggc caaagcaatt gaacctcccc ctttggatgc tgtgattgaa   2640

gcagaacaca ctcttagaga gcttgatgca ttagatgcca atgatgagtt gactcctttg   2700

ggacgaatcc tggctaaact ccccattgag cctcgttttg gcaaaatgat gataatgggg   2760

tgtattttct acgtgggaga tgctatctgt accattgctg ctgctacctg ctttccagag   2820

cctttcatca atgaaggaaa gcggctgggc tatatccatc gaaattttgc tggaaacaga   2880

ttttctgatc acgtagccct tttatcagta ttccaagcct gggatgatgc tagaatgggt   2940

ggagaagaag cagagatacg tttttgtgag cacaaaagac ttaatatggc tacactaaga   3000

atgacttggg aagccaaagt tcagctcaaa gagattttga ttaattctgg gtttccagaa   3060

gattgtttgt tgacacaagt gtttactaac actggaccag ataataattt ggatgttgtt   3120

atctccctcc tggcctttgt agccaagaca tgaagtaccc atctcccttc tttgtatttg   3180

gtgaaaagat tcgaactcga gccatctctg ctaaaggcat gactttagtc acccccctgc   3240

agttgcttct ctttgcctcc aagaaagtcc aatctgatgg gcagattgtg cttgtagatg   3300

actggattaa actgcaaata tctcatgaag ctgctgcctg tatcactggt ctccgggcag   3360

ccatggaggc tttggttgtt gaagtaacca aacaacctgc tatcatcagc cagttggacc   3420

ccgtaaatga acgtatgctg aacatgatcc gtcagatctc tagaccctca gctgctggta   3480

tcaaccttat gattggcagt acacggtatg gagatggtcc acgtcctccc aagatggccc   3540

gatacgacaa tggaagcgga tatagaaggg gaggttctag ttacagtggt ggaggctatg   3600

gcggtggcta tagcagtgga ggctatggta gcggaggcta tggtggcagc gccaactcct   3660

ttcgggcagg atatggtgca ggtgttggtg gaggctatag aggagtttcc cgaggtggct   3720

ttagaggcaa ctctggagga gactacagag ggcctagtgg aggctacaga ggatctgggg   3780

gattccagcg aggaggtggt aggggggcct atggaactgg ctactttgga cagggaagag   3840

gaggtggcgg ctattaaaac ttggttatgt cagttcctgt gtgtagacag taaggaaaaa   3900

aaggcatgct atgtgttacg tgttttttcc agtatgttta tttgccacca aaaagtaaat   3960

gcattttcac ccattctgtg gttcattgta gtttaaggaa accaagcata tagatgcatt   4020

agtgattttg tttatattat gtaaaatata acgatctctt aaaaatacca cagtttgtat   4080

tttttcttta aggagtaaag atttgccttt aaataacttg gtattttcct ggctttcgtt   4140

taatacaata gaaaataaag tattacaccg aat                                4173


<210>  6786
<211>  1001
<212>  PRT
<213>  Homosapiens

<400>  6786

Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys 
1               5                   10                  15      


Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln 
            20                  25                  30          


Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met 
        35                  40                  45              


Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp 
    50                  55                  60                  


Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val 
65                  70                  75                  80  


Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp 
                85                  90                  95      


Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro 
            100                 105                 110         


Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly 
        115                 120                 125             


Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn 
    130                 135                 140                 


Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr 
145                 150                 155                 160 


Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp 
                165                 170                 175     


Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu 
            180                 185                 190         


Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn 
        195                 200                 205             


Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg 
    210                 215                 220                 


Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln 
225                 230                 235                 240 


Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val 
                245                 250                 255     


Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu 
            260                 265                 270         


Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn 
        275                 280                 285             


Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro 
    290                 295                 300                 


Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro 
305                 310                 315                 320 


Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln 
                325                 330                 335     


Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu 
            340                 345                 350         


Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu 
        355                 360                 365             


Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu 
    370                 375                 380                 


Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala 
385                 390                 395                 400 


Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly 
                405                 410                 415     


Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn 
            420                 425                 430         


Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile 
        435                 440                 445             


Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu 
    450                 455                 460                 


Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro 
465                 470                 475                 480 


Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg 
                485                 490                 495     


Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu 
            500                 505                 510         


Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg 
        515                 520                 525             


Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala 
    530                 535                 540                 


Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile 
545                 550                 555                 560 


Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu 
                565                 570                 575     


Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys 
            580                 585                 590         


Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys 
        595                 600                 605             


Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met 
    610                 615                 620                 


Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu 
625                 630                 635                 640 


Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe 
                645                 650                 655     


Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met 
            660                 665                 670         


Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser 
        675                 680                 685             


Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val 
    690                 695                 700                 


Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile 
705                 710                 715                 720 


Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val 
                725                 730                 735     


Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr Val Trp 
            740                 745                 750         


Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Val 
        755                 760                 765             


Arg Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg 
    770                 775                 780                 


Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu 
785                 790                 795                 800 


Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe 
                805                 810                 815     


Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala 
            820                 825                 830         


Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu 
        835                 840                 845             


Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe 
    850                 855                 860                 


Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile 
865                 870                 875                 880 


Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu 
                885                 890                 895     


Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe 
            900                 905                 910         


Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala 
        915                 920                 925             


Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg 
    930                 935                 940                 


Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu 
945                 950                 955                 960 


Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr 
                965                 970                 975     


Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile 
            980                 985                 990         


Ser Leu Leu Ala Phe Val Ala Lys  Thr 
        995                 1000     


<210>  6787
<211>  4276
<212>  DNA
<213>  Homosapiens

<400>  6787
agcgccgcgg tcggagccat ttcgccgatt cctccatgcg agttgctgtg cgtttctctg     60

ttgtctcggt agaaggccag agtcacacac ggtcctaaga gctgggcacc aggaagcgaa    120

ggctgatctg aagaagacac ttgaatcatg ggtgacgtta aaaattttct gtatgcctgg    180

tgtggcaaaa ggaagatgac cccatcctat gaaattagag cagtggggaa caaaaacagg    240

cagaaattca tgtgtgaggt tcaggtggaa ggttataatt acactggcat gggaaattcc    300

accaataaaa aagatgcaca aagcaatgct gccagagact ttgttaacta tttggttcga    360

ataaatgaaa taaagagtga agaagttcca gcttttgggg tagcatctcc gcccccactt    420

actgatactc ctgacactac agcaaatgct gaaggagatt taccaacaac catgggagga    480

cctcttcctc cacatctggc tctcaaagca gaaaataatt ctgaggtagg ggcctctggc    540

tatggtgttc ctgggcccac ctgggaccga ggagccaact tgaaggatta ctactcaaga    600

aaggaagaac aagaagtgca agcgactcta gaatcagaag aagtggattt aaatgctggg    660

cttcatggaa actggacctt ggaaaatgct aaagctcgtc taaaccaata ttttcagaaa    720

gaaaagatcc aaggagaata taagtacacc caagtgggtc ctgatcacaa caggagcttt    780

attgcagaaa tgaccattta tatcaagcag ctgggcagaa ggatttttgc acgagaacat    840

ggatcaaata agaaattggc agcacagtcc tgtgccctgt cacttgtcag acaactgtac    900

catcttggag tggttgaagc ttactccgga cttacaaaga agaaggaagg agagacagtg    960

gagccttaca aagtaaacct ctctcaagat ttagagcatc agctgcaaaa catcattcaa   1020

gagctaaatc ttgagatttt gcccccgcct gaagatcctt ctgtgccagt tgcactcaac   1080

attggcaaat tggctcagtt cgaaccatct cagcgacaaa accaagtggg tgtggttcct   1140

tggtcacctc cacaatccaa ctggaatcct tggactagta gcaacattga tgaggggcct   1200

ctggcttttg ctactccaga gcaaataagc atggacctca agaatgaatt gatgtaccag   1260

ttggaacagg atcatgattt gcaagcaatc ttgcaggaga gagagttact gcctgtgaag   1320

aaatttgaaa gtgagattct ggaagcaatc agccaaaatt cagttgtcat tattagaggg   1380

gctactggat gtgggaaaac cacacaggtt ccccagttca ttctagatga ctttatccag   1440

aatgaccgag cagcagagtg taacatcgta gtaactcagc ccagaagaat cagtgcggtt   1500

tctgtggcag agcgagttgc atttgaaaga ggagaagagc ctggaaaaag ctgtggctac   1560

agcgttcgat ttgagtctat acttcctcgt cctcatgcca gtataatgtt ttgtactgta   1620

ggtgtgctcc tgagaaaatt agaagcaggc attcgaggaa tcagtcatgt aattgtagat   1680

gaaatacatg aaagagatat taatactgac ttccttttgg tagtactgcg tgatgttgtt   1740

caggcttatc ctgaagttcg cattgttctt atgtctgcta ctattgatac cagcatgttt   1800

tgtgaatatt tcttcaattg ccccatcatt gaagtttatg ggaggactta cccagttcaa   1860

gaatattttc tggaagactg cattcagatg acccactttg ttcctccacc aaaagacaaa   1920

aagaagaagg ataaggatga tgatggtggt gaggatgatg atgcaaattg caacttgatc   1980

tgtggtgatg aatatggtcc agaaacaagg ttgagcatgt ctcaattgaa cgaaaaggaa   2040

actccttttg aactcatcga ggctctactt aagtacattg aaacccttaa tgttcctgga   2100

gctgtgttgg tttttttgcc tggctggaat ctgatttata ctatgcagaa gcatttggaa   2160

atgaatccac attttggaag ccatcggtat cagattctac ccctgcattc tcagattcct   2220

cgagaggaac agcgcaaagt gtttgatcca gtaccagttg gagtaaccaa ggttattttg   2280

tccacaaata ttgctgaaac aagcattacc ataaacgatg ttgtttatgt cattgactcc   2340

tgcaagcaga aagtgaaact cttcactgct cacaacaata tgaccaacta tgctaccgta   2400

tgggcatcaa aaacaaacct tgagcaacgg aaagggcgag ctggccgagt acggcctgga   2460

ttctgctttc acctgtgcag ccgagctcgt tttgagagac ttgaaaccca catgacacca   2520

gagatgttcc gaacaccatt gcatgaaatt gctcttagca taaaacttct gcgtctagga   2580

ggaattggcc aatttctggc caaagcaatt gaacctcccc ctttggatgc tgtgattgaa   2640

gcagaacaca ctcttagaga gcttgatgca ttagatgcca atgatgagtt gactcctttg   2700

ggacgaatcc tggctaaact ccccattgag cctcgttttg gcaaaatgat gataatgggg   2760

tgtattttct acgtgggaga tgctatctgt accattgctg ctgctacctg ctttccagag   2820

cctttcatca atgaaggaaa gcggctgggc tatatccatc gaaattttgc tggaaacaga   2880

ttttctgatc acgtagccct tttatcagta ttccaagcct gggatgatgc tagaatgggt   2940

ggagaagaag cagagatacg tttttgtgag cacaaaagac ttaatatggc tacactaaga   3000

atgacttggg aagccaaagt tcagctcaaa gagattttga ttaattctgg gtttccagaa   3060

gattgtttgt tgacacaagt gtttactaac actggaccag ataataattt ggatgttgtt   3120

atctccctcc tggcctttgg tgtgtacccc aatgtatgct atcataagga aaagaggaag   3180

attctcacca ctgaagggcg taatgcactt atccacaaat catctgttaa ttgtcctttt   3240

agtagccaag acatgaagta cccatctccc ttctttgtat ttggtgaaaa gattcgaact   3300

cgagccatct ctgctaaagg catgacttta gtcacccccc tgcagttgct tctctttgcc   3360

tccaagaaag tccaatctga tgggcagatt gtgcttgtag atgactggat taaactgcaa   3420

atatctcatg aagctgctgc ctgtatcact ggtctccggg cagccatgga ggctttggtt   3480

gttgaagtaa ccaaacaacc tgctatcatc agccagttgg accccgtaaa tgaacgtatg   3540

ctgaacatga tccgtcagat ctctagaccc tcagctgctg gtatcaacct tatgattggc   3600

agtacacggt atggagatgg tccacgtcct cccaagatgg cccgatacga caatggaagc   3660

ggatatagaa ggggaggttc tagttacagt ggtggaggct atggcggtgg ctatagcagt   3720

ggaggctatg gtagcggagg ctatggtggc agcgccaact cctttcgggc aggatatggt   3780

gcaggtgttg gtggaggcta tagaggagtt tcccgaggtg gctttagagg caactctgga   3840

ggagactaca gagggcctag tggaggctac agaggatctg ggggattcca gcgaggaggt   3900

ggtagggggg cctatggaac tggctacttt ggacagggaa gaggaggtgg cggctattaa   3960

aacttggtta tgtcagttcc tgtgtgtaga cagtaaggaa aaaaaggcat gctatgtgtt   4020

acgtgttttt tccagtatgt ttatttgcca ccaaaaagta aatgcatttt cacccattct   4080

gtggttcatt gtagtttaag gaaaccaagc atatagatgc attagtgatt ttgtttatat   4140

tatgtaaaat ataacgatct cttaaaaata ccacagtttg tattttttct ttaaggagta   4200

aagatttgcc tttaaataac ttggtatttt cctggctttc gtttaataca atagaaaata   4260

aagtattaca ccgaat                                                   4276


<210>  6788
<211>  1270
<212>  PRT
<213>  Homosapiens

<400>  6788

Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys 
1               5                   10                  15      


Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln 
            20                  25                  30          


Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met 
        35                  40                  45              


Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp 
    50                  55                  60                  


Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val 
65                  70                  75                  80  


Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp 
                85                  90                  95      


Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro 
            100                 105                 110         


Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly 
        115                 120                 125             


Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn 
    130                 135                 140                 


Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr 
145                 150                 155                 160 


Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp 
                165                 170                 175     


Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu 
            180                 185                 190         


Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn 
        195                 200                 205             


Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg 
    210                 215                 220                 


Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln 
225                 230                 235                 240 


Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val 
                245                 250                 255     


Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu 
            260                 265                 270         


Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn 
        275                 280                 285             


Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro 
    290                 295                 300                 


Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro 
305                 310                 315                 320 


Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln 
                325                 330                 335     


Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu 
            340                 345                 350         


Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu 
        355                 360                 365             


Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu 
    370                 375                 380                 


Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala 
385                 390                 395                 400 


Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly 
                405                 410                 415     


Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn 
            420                 425                 430         


Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile 
        435                 440                 445             


Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu 
    450                 455                 460                 


Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro 
465                 470                 475                 480 


Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg 
                485                 490                 495     


Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu 
            500                 505                 510         


Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg 
        515                 520                 525             


Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala 
    530                 535                 540                 


Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile 
545                 550                 555                 560 


Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu 
                565                 570                 575     


Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys 
            580                 585                 590         


Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys 
        595                 600                 605             


Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met 
    610                 615                 620                 


Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu 
625                 630                 635                 640 


Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe 
                645                 650                 655     


Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met 
            660                 665                 670         


Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser 
        675                 680                 685             


Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val 
    690                 695                 700                 


Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile 
705                 710                 715                 720 


Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val 
                725                 730                 735     


Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr Val Trp 
            740                 745                 750         


Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Val 
        755                 760                 765             


Arg Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg 
    770                 775                 780                 


Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu 
785                 790                 795                 800 


Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe 
                805                 810                 815     


Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala 
            820                 825                 830         


Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu 
        835                 840                 845             


Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe 
    850                 855                 860                 


Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile 
865                 870                 875                 880 


Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu 
                885                 890                 895     


Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe 
            900                 905                 910         


Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala 
        915                 920                 925             


Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg 
    930                 935                 940                 


Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu 
945                 950                 955                 960 


Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr 
                965                 970                 975     


Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile 
            980                 985                 990         


Ser Leu Leu Ala Phe Gly Val Tyr  Pro Asn Val Cys Tyr  His Lys Glu 
        995                 1000                 1005             


Lys Arg  Lys Ile Leu Thr Thr  Glu Gly Arg Asn Ala  Leu Ile His 
    1010                 1015                 1020             


Lys Ser  Ser Val Asn Cys Pro  Phe Ser Ser Gln Asp  Met Lys Tyr 
    1025                 1030                 1035             


Pro Ser  Pro Phe Phe Val Phe  Gly Glu Lys Ile Arg  Thr Arg Ala 
    1040                 1045                 1050             


Ile Ser  Ala Lys Gly Met Thr  Leu Val Thr Pro Leu  Gln Leu Leu 
    1055                 1060                 1065             


Leu Phe  Ala Ser Lys Lys Val  Gln Ser Asp Gly Gln  Ile Val Leu 
    1070                 1075                 1080             


Val Asp  Asp Trp Ile Lys Leu  Gln Ile Ser His Glu  Ala Ala Ala 
    1085                 1090                 1095             


Cys Ile  Thr Gly Leu Arg Ala  Ala Met Glu Ala Leu  Val Val Glu 
    1100                 1105                 1110             


Val Thr  Lys Gln Pro Ala Ile  Ile Ser Gln Leu Asp  Pro Val Asn 
    1115                 1120                 1125             


Glu Arg  Met Leu Asn Met Ile  Arg Gln Ile Ser Arg  Pro Ser Ala 
    1130                 1135                 1140             


Ala Gly  Ile Asn Leu Met Ile  Gly Ser Thr Arg Tyr  Gly Asp Gly 
    1145                 1150                 1155             


Pro Arg  Pro Pro Lys Met Ala  Arg Tyr Asp Asn Gly  Ser Gly Tyr 
    1160                 1165                 1170             


Arg Arg  Gly Gly Ser Ser Tyr  Ser Gly Gly Gly Tyr  Gly Gly Gly 
    1175                 1180                 1185             


Tyr Ser  Ser Gly Gly Tyr Gly  Ser Gly Gly Tyr Gly  Gly Ser Ala 
    1190                 1195                 1200             


Asn Ser  Phe Arg Ala Gly Tyr  Gly Ala Gly Val Gly  Gly Gly Tyr 
    1205                 1210                 1215             


Arg Gly  Val Ser Arg Gly Gly  Phe Arg Gly Asn Ser  Gly Gly Asp 
    1220                 1225                 1230             


Tyr Arg  Gly Pro Ser Gly Gly  Tyr Arg Gly Ser Gly  Gly Phe Gln 
    1235                 1240                 1245             


Arg Gly  Gly Gly Arg Gly Ala  Tyr Gly Thr Gly Tyr  Phe Gly Gln 
    1250                 1255                 1260             


Gly Arg  Gly Gly Gly Gly Tyr  
    1265                 1270 


<210>  6789
<211>  4405
<212>  DNA
<213>  Homosapiens

<400>  6789
agcgccgcgg tcggagccat ttcgccgatt cctccatgcg agttgctgtg cgtttctctg     60

ttgtctcggt agaaggccag agtcacacac ggtcctaaga gctgggcacc aggaagcgaa    120

ggctgatctg aagaagacac ttgaatcatg ggtgacgtta aaaattttct gtatgcctgg    180

tgtggcaaaa ggaagatgac cccatcctat gaaattagag cagtggggaa caaaaacagg    240

cagaaattca tgtgtgaggt tcaggtggaa ggttataatt acactggcat gggaaattcc    300

accaataaaa aagatgcaca aagcaatgct gccagagact ttgttaacta tttggttcga    360

ataaatgaaa taaagagtga agaagttcca gcttttgggg tagcatctcc gcccccactt    420

actgatactc ctgacactac agcaaatgct gaaggagatt taccaacaac catgggagga    480

cctcttcctc cacatctggc tctcaaagca gaaaataatt ctgaggtagg ggcctctggc    540

tatggtgttc ctgggcccac ctgggaccga ggagccaact tgaaggatta ctactcaaga    600

aaggaagaac aagaagtgca agcgactcta gaatcagaag aagtggattt aaatgctggg    660

cttcatggaa actggacctt ggaaaatgct aaagctcgtc taaaccaata ttttcagaaa    720

gaaaagatcc aaggagaata taagtacacc caagtgggtc ctgatcacaa caggagcttt    780

attgcagaaa tgaccattta tatcaagcag ctgggcagaa ggatttttgc acgagaacat    840

ggatcaaata agaaattggc agcacagtcc tgtgccctgt cacttgtcag acaactgtac    900

catcttggag tggttgaagc ttactccgga cttacaaaga agaaggaagg agagacagtg    960

gagccttaca aagtaaacct ctctcaagat ttagagcatc agctgcaaaa catcattcaa   1020

gagctaaatc ttgagatttt gcccccgcct gaagatcctt ctgtgccagt tgcactcaac   1080

attggcaaat tggctcagtt cgaaccatct cagcgacaaa accaagtggg tgtggttcct   1140

tggtcacctc cacaatccaa ctggaatcct tggactagta gcaacattga tgaggggcct   1200

ctggcttttg ctactccaga gcaaataagc atggacctca agaatgaatt gatgtaccag   1260

ttggaacagg atcatgattt gcaagcaatc ttgcaggaga gagagttact gcctgtgaag   1320

aaatttgaaa gtgagattct ggaagcaatc agccaaaatt cagttgtcat tattagaggg   1380

gctactggat gtgggaaaac cacacaggtt ccccagttca ttctagatga ctttatccag   1440

aatgaccgag cagcagagtg taacatcgta gtaactcagc ccagaagaat cagtgcggtt   1500

tctgtggcag agcgagttgc atttgaaaga ggagaagagc ctggaaaaag ctgtggctac   1560

agcgttcgat ttgagtctat acttcctcgt cctcatgcca gtataatgtt ttgtactgta   1620

ggtgtgctcc tgagaaaatt agaagcaggc attcgaggaa tcagtcatgt aattgtagat   1680

gaaatacatg aaagagatat taatactgac ttccttttgg tagtactgcg tgatgttgtt   1740

caggcttatc ctgaagttcg cattgttctt atgtctgcta ctattgatac cagcatgttt   1800

tgtgaatatt tcttcaattg ccccatcatt gaagtttatg ggaggactta cccagttcaa   1860

gaatattttc tggaagactg cattcagatg acccactttg ttcctccacc aaaagacaaa   1920

aagaagaagg ataaggatga tgatggtggt gaggatgatg atgcaaattg caacttgatc   1980

tgtggtgatg aatatggtcc agaaacaagg ttgagcatgt ctcaattgaa cgaaaaggaa   2040

actccttttg aactcatcga ggctctactt aagtacattg aaacccttaa tgttcctgga   2100

gctgtgttgg tttttttgcc tggctggaat ctgatttata ctatgcagaa gcatttggaa   2160

atgaatccac attttggaag ccatcggtat cagattctac ccctgcattc tcagattcct   2220

cgagaggaac agcgcaaagt gtttgatcca gtaccagttg gagtaaccaa ggttattttg   2280

tccacaaata ttgctgaaac aagcattacc ataaacgatg ttgtttatgt cattgactcc   2340

tgcaagcaga aagtgaaact cttcactgct cacaacaata tgaccaacta tgctaccgta   2400

tgggcatcaa aaacaaacct tgagcaacgg aaagggcgag ctggccgagt acggcctgga   2460

ttctgctttc acctgtgcag ccgagctcgt tttgagagac ttgaaaccca catgacacca   2520

gagatgttcc gaacaccatt gcatgaaatt gctcttagca taaaacttct gcgtctagga   2580

ggaattggcc aatttctggc caaagcaatt gaacctcccc ctttggatgc tgtgattgaa   2640

gcagaacaca ctcttagaga gcttgatgca ttagatgcca atgatgagtt gactcctttg   2700

ggacgaatcc tggctaaact ccccattgag cctcgttttg gcaaaatgat gataatgggg   2760

tgtattttct acgtgggaga tgctatctgt accattgctg ctgctacctg ctttccagag   2820

cctttcatca atgaaggaaa gcggctgggc tatatccatc gaaattttgc tggaaacaga   2880

ttttctgatc acgtagccct tttatcagta ttccaagcct gggatgatgc tagaatgggt   2940

ggagaagaag cagagatacg tttttgtgag cacaaaagac ttaatatggc tacactaaga   3000

atgacttggg aagccaaagt tcagctcaaa gagattttga ttaattctgg gtttccagaa   3060

gattgtttgt tgacacaagt gtttactaac actggaccag ataataattt ggatgttgtt   3120

atctccctcc tggcctttgt agccaagaca tgaagtaccc atctcccttc tttgtatttg   3180

gtgaaaagat tcgaactcga gccatctctg ctaaaggcat gactttagtc acccccctgc   3240

agttgcttct ctttgcctcc aagaaagtcc aatctgatgg gcagattgtg cttgtagatg   3300

actggattaa actgcaaata tctcatgaag ctgctgcctg tatcactggt ctccgggcag   3360

ccatggaggc tttggttgtt gaagtaacca aacaacctgc tatcatcagc cagttggacc   3420

ccgtaaatga acgtatgctg aacatgatcc gtcagatctc tagaccctca gctgctggta   3480

tcaaccttat gattggcagt acacggtatg gagatggtcc acgtcctccc aagatggccc   3540

gatacgacaa tggaagcgga tatagaaggg gaggttctag ttacagtggt ggaggctatg   3600

gcggtggcta tagcagtgga ggctatggta gcggaggcta tggtggcagc gccaactcct   3660

ttcgggcagg atatggtgca ggtgttggtg gaggctatag aggagtttcc cgaggtggct   3720

ttagaggcaa ctctggagga gactacagag ggcctagtgg aggctacaga ggatctgggg   3780

gattccagcg aggaggtggt aggggggcct atggaactgg ctactttgga cagggaagag   3840

gaggtggcgg ctattaaaac ttggttatgt cagttcctgt gtgtagacag taaggaaaaa   3900

aaggcatgct atgtgttacg tgttttttcc agtatgttta tttgccacca aaaagtaaat   3960

gcattttcac ccattctgtg gttcattgta gtttaaggaa accaagcata tagatgcatt   4020

agtgattttg tttatattat gtaaaatata acgatctctt aaaaatacca cagtttgtat   4080

tttttcttta aggagtaaag atttgccttt aaataacttg gtattttcct ggctttcgtt   4140

taatacaata gaaaataaag tattacaccg aatacttgcc gtgtagtttg tttgttgacc   4200

tcgtatgtta gaaaatttta caatgccagc tacatctgtt gattttaaat gtcagagaag   4260

ttgtaccctg tttcaaaagt atactaagtg atactacttg taatagaata aatcatcttg   4320

gaattgaatt gttacctttt gaagtaaata ctggcaagtg cacaagccac ataaacctga   4380

ataaaacttt tgacctaggg ttgaa                                         4405


<210>  6790
<211>  1001
<212>  PRT
<213>  Homosapiens

<400>  6790

Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys 
1               5                   10                  15      


Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln 
            20                  25                  30          


Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met 
        35                  40                  45              


Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp 
    50                  55                  60                  


Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val 
65                  70                  75                  80  


Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp 
                85                  90                  95      


Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro 
            100                 105                 110         


Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly 
        115                 120                 125             


Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn 
    130                 135                 140                 


Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr 
145                 150                 155                 160 


Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp 
                165                 170                 175     


Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu 
            180                 185                 190         


Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn 
        195                 200                 205             


Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg 
    210                 215                 220                 


Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln 
225                 230                 235                 240 


Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val 
                245                 250                 255     


Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu 
            260                 265                 270         


Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn 
        275                 280                 285             


Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro 
    290                 295                 300                 


Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro 
305                 310                 315                 320 


Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln 
                325                 330                 335     


Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu 
            340                 345                 350         


Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu 
        355                 360                 365             


Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu 
    370                 375                 380                 


Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala 
385                 390                 395                 400 


Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly 
                405                 410                 415     


Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn 
            420                 425                 430         


Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile 
        435                 440                 445             


Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu 
    450                 455                 460                 


Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro 
465                 470                 475                 480 


Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg 
                485                 490                 495     


Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu 
            500                 505                 510         


Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg 
        515                 520                 525             


Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala 
    530                 535                 540                 


Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile 
545                 550                 555                 560 


Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu 
                565                 570                 575     


Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys 
            580                 585                 590         


Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys 
        595                 600                 605             


Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met 
    610                 615                 620                 


Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu 
625                 630                 635                 640 


Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe 
                645                 650                 655     


Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met 
            660                 665                 670         


Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser 
        675                 680                 685             


Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val 
    690                 695                 700                 


Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile 
705                 710                 715                 720 


Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val 
                725                 730                 735     


Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr Val Trp 
            740                 745                 750         


Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Val 
        755                 760                 765             


Arg Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg 
    770                 775                 780                 


Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu 
785                 790                 795                 800 


Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe 
                805                 810                 815     


Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala 
            820                 825                 830         


Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu 
        835                 840                 845             


Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe 
    850                 855                 860                 


Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile 
865                 870                 875                 880 


Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu 
                885                 890                 895     


Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe 
            900                 905                 910         


Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala 
        915                 920                 925             


Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg 
    930                 935                 940                 


Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu 
945                 950                 955                 960 


Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr 
                965                 970                 975     


Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile 
            980                 985                 990         


Ser Leu Leu Ala Phe Val Ala Lys  Thr 
        995                 1000     


<210>  6791
<211>  4508
<212>  DNA
<213>  Homosapiens

<400>  6791
agcgccgcgg tcggagccat ttcgccgatt cctccatgcg agttgctgtg cgtttctctg     60

ttgtctcggt agaaggccag agtcacacac ggtcctaaga gctgggcacc aggaagcgaa    120

ggctgatctg aagaagacac ttgaatcatg ggtgacgtta aaaattttct gtatgcctgg    180

tgtggcaaaa ggaagatgac cccatcctat gaaattagag cagtggggaa caaaaacagg    240

cagaaattca tgtgtgaggt tcaggtggaa ggttataatt acactggcat gggaaattcc    300

accaataaaa aagatgcaca aagcaatgct gccagagact ttgttaacta tttggttcga    360

ataaatgaaa taaagagtga agaagttcca gcttttgggg tagcatctcc gcccccactt    420

actgatactc ctgacactac agcaaatgct gaaggagatt taccaacaac catgggagga    480

cctcttcctc cacatctggc tctcaaagca gaaaataatt ctgaggtagg ggcctctggc    540

tatggtgttc ctgggcccac ctgggaccga ggagccaact tgaaggatta ctactcaaga    600

aaggaagaac aagaagtgca agcgactcta gaatcagaag aagtggattt aaatgctggg    660

cttcatggaa actggacctt ggaaaatgct aaagctcgtc taaaccaata ttttcagaaa    720

gaaaagatcc aaggagaata taagtacacc caagtgggtc ctgatcacaa caggagcttt    780

attgcagaaa tgaccattta tatcaagcag ctgggcagaa ggatttttgc acgagaacat    840

ggatcaaata agaaattggc agcacagtcc tgtgccctgt cacttgtcag acaactgtac    900

catcttggag tggttgaagc ttactccgga cttacaaaga agaaggaagg agagacagtg    960

gagccttaca aagtaaacct ctctcaagat ttagagcatc agctgcaaaa catcattcaa   1020

gagctaaatc ttgagatttt gcccccgcct gaagatcctt ctgtgccagt tgcactcaac   1080

attggcaaat tggctcagtt cgaaccatct cagcgacaaa accaagtggg tgtggttcct   1140

tggtcacctc cacaatccaa ctggaatcct tggactagta gcaacattga tgaggggcct   1200

ctggcttttg ctactccaga gcaaataagc atggacctca agaatgaatt gatgtaccag   1260

ttggaacagg atcatgattt gcaagcaatc ttgcaggaga gagagttact gcctgtgaag   1320

aaatttgaaa gtgagattct ggaagcaatc agccaaaatt cagttgtcat tattagaggg   1380

gctactggat gtgggaaaac cacacaggtt ccccagttca ttctagatga ctttatccag   1440

aatgaccgag cagcagagtg taacatcgta gtaactcagc ccagaagaat cagtgcggtt   1500

tctgtggcag agcgagttgc atttgaaaga ggagaagagc ctggaaaaag ctgtggctac   1560

agcgttcgat ttgagtctat acttcctcgt cctcatgcca gtataatgtt ttgtactgta   1620

ggtgtgctcc tgagaaaatt agaagcaggc attcgaggaa tcagtcatgt aattgtagat   1680

gaaatacatg aaagagatat taatactgac ttccttttgg tagtactgcg tgatgttgtt   1740

caggcttatc ctgaagttcg cattgttctt atgtctgcta ctattgatac cagcatgttt   1800

tgtgaatatt tcttcaattg ccccatcatt gaagtttatg ggaggactta cccagttcaa   1860

gaatattttc tggaagactg cattcagatg acccactttg ttcctccacc aaaagacaaa   1920

aagaagaagg ataaggatga tgatggtggt gaggatgatg atgcaaattg caacttgatc   1980

tgtggtgatg aatatggtcc agaaacaagg ttgagcatgt ctcaattgaa cgaaaaggaa   2040

actccttttg aactcatcga ggctctactt aagtacattg aaacccttaa tgttcctgga   2100

gctgtgttgg tttttttgcc tggctggaat ctgatttata ctatgcagaa gcatttggaa   2160

atgaatccac attttggaag ccatcggtat cagattctac ccctgcattc tcagattcct   2220

cgagaggaac agcgcaaagt gtttgatcca gtaccagttg gagtaaccaa ggttattttg   2280

tccacaaata ttgctgaaac aagcattacc ataaacgatg ttgtttatgt cattgactcc   2340

tgcaagcaga aagtgaaact cttcactgct cacaacaata tgaccaacta tgctaccgta   2400

tgggcatcaa aaacaaacct tgagcaacgg aaagggcgag ctggccgagt acggcctgga   2460

ttctgctttc acctgtgcag ccgagctcgt tttgagagac ttgaaaccca catgacacca   2520

gagatgttcc gaacaccatt gcatgaaatt gctcttagca taaaacttct gcgtctagga   2580

ggaattggcc aatttctggc caaagcaatt gaacctcccc ctttggatgc tgtgattgaa   2640

gcagaacaca ctcttagaga gcttgatgca ttagatgcca atgatgagtt gactcctttg   2700

ggacgaatcc tggctaaact ccccattgag cctcgttttg gcaaaatgat gataatgggg   2760

tgtattttct acgtgggaga tgctatctgt accattgctg ctgctacctg ctttccagag   2820

cctttcatca atgaaggaaa gcggctgggc tatatccatc gaaattttgc tggaaacaga   2880

ttttctgatc acgtagccct tttatcagta ttccaagcct gggatgatgc tagaatgggt   2940

ggagaagaag cagagatacg tttttgtgag cacaaaagac ttaatatggc tacactaaga   3000

atgacttggg aagccaaagt tcagctcaaa gagattttga ttaattctgg gtttccagaa   3060

gattgtttgt tgacacaagt gtttactaac actggaccag ataataattt ggatgttgtt   3120

atctccctcc tggcctttgg tgtgtacccc aatgtatgct atcataagga aaagaggaag   3180

attctcacca ctgaagggcg taatgcactt atccacaaat catctgttaa ttgtcctttt   3240

agtagccaag acatgaagta cccatctccc ttctttgtat ttggtgaaaa gattcgaact   3300

cgagccatct ctgctaaagg catgacttta gtcacccccc tgcagttgct tctctttgcc   3360

tccaagaaag tccaatctga tgggcagatt gtgcttgtag atgactggat taaactgcaa   3420

atatctcatg aagctgctgc ctgtatcact ggtctccggg cagccatgga ggctttggtt   3480

gttgaagtaa ccaaacaacc tgctatcatc agccagttgg accccgtaaa tgaacgtatg   3540

ctgaacatga tccgtcagat ctctagaccc tcagctgctg gtatcaacct tatgattggc   3600

agtacacggt atggagatgg tccacgtcct cccaagatgg cccgatacga caatggaagc   3660

ggatatagaa ggggaggttc tagttacagt ggtggaggct atggcggtgg ctatagcagt   3720

ggaggctatg gtagcggagg ctatggtggc agcgccaact cctttcgggc aggatatggt   3780

gcaggtgttg gtggaggcta tagaggagtt tcccgaggtg gctttagagg caactctgga   3840

ggagactaca gagggcctag tggaggctac agaggatctg ggggattcca gcgaggaggt   3900

ggtagggggg cctatggaac tggctacttt ggacagggaa gaggaggtgg cggctattaa   3960

aacttggtta tgtcagttcc tgtgtgtaga cagtaaggaa aaaaaggcat gctatgtgtt   4020

acgtgttttt tccagtatgt ttatttgcca ccaaaaagta aatgcatttt cacccattct   4080

gtggttcatt gtagtttaag gaaaccaagc atatagatgc attagtgatt ttgtttatat   4140

tatgtaaaat ataacgatct cttaaaaata ccacagtttg tattttttct ttaaggagta   4200

aagatttgcc tttaaataac ttggtatttt cctggctttc gtttaataca atagaaaata   4260

aagtattaca ccgaatactt gccgtgtagt ttgtttgttg acctcgtatg ttagaaaatt   4320

ttacaatgcc agctacatct gttgatttta aatgtcagag aagttgtacc ctgtttcaaa   4380

agtatactaa gtgatactac ttgtaataga ataaatcatc ttggaattga attgttacct   4440

tttgaagtaa atactggcaa gtgcacaagc cacataaacc tgaataaaac ttttgaccta   4500

gggttgaa                                                            4508


<210>  6792
<211>  1270
<212>  PRT
<213>  Homosapiens

<400>  6792

Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys 
1               5                   10                  15      


Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln 
            20                  25                  30          


Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met 
        35                  40                  45              


Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp 
    50                  55                  60                  


Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val 
65                  70                  75                  80  


Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp 
                85                  90                  95      


Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro 
            100                 105                 110         


Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly 
        115                 120                 125             


Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn 
    130                 135                 140                 


Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr 
145                 150                 155                 160 


Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp 
                165                 170                 175     


Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu 
            180                 185                 190         


Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn 
        195                 200                 205             


Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg 
    210                 215                 220                 


Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln 
225                 230                 235                 240 


Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val 
                245                 250                 255     


Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu 
            260                 265                 270         


Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn 
        275                 280                 285             


Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro 
    290                 295                 300                 


Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro 
305                 310                 315                 320 


Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln 
                325                 330                 335     


Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu 
            340                 345                 350         


Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu 
        355                 360                 365             


Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu 
    370                 375                 380                 


Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala 
385                 390                 395                 400 


Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly 
                405                 410                 415     


Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn 
            420                 425                 430         


Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile 
        435                 440                 445             


Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu 
    450                 455                 460                 


Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro 
465                 470                 475                 480 


Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg 
                485                 490                 495     


Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu 
            500                 505                 510         


Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg 
        515                 520                 525             


Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala 
    530                 535                 540                 


Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile 
545                 550                 555                 560 


Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu 
                565                 570                 575     


Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys 
            580                 585                 590         


Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys 
        595                 600                 605             


Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met 
    610                 615                 620                 


Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu 
625                 630                 635                 640 


Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe 
                645                 650                 655     


Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met 
            660                 665                 670         


Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser 
        675                 680                 685             


Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val 
    690                 695                 700                 


Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile 
705                 710                 715                 720 


Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val 
                725                 730                 735     


Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr Val Trp 
            740                 745                 750         


Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Val 
        755                 760                 765             


Arg Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg 
    770                 775                 780                 


Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu 
785                 790                 795                 800 


Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe 
                805                 810                 815     


Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala 
            820                 825                 830         


Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu 
        835                 840                 845             


Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe 
    850                 855                 860                 


Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile 
865                 870                 875                 880 


Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu 
                885                 890                 895     


Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe 
            900                 905                 910         


Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala 
        915                 920                 925             


Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg 
    930                 935                 940                 


Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu 
945                 950                 955                 960 


Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr 
                965                 970                 975     


Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile 
            980                 985                 990         


Ser Leu Leu Ala Phe Gly Val Tyr  Pro Asn Val Cys Tyr  His Lys Glu 
        995                 1000                 1005             


Lys Arg  Lys Ile Leu Thr Thr  Glu Gly Arg Asn Ala  Leu Ile His 
    1010                 1015                 1020             


Lys Ser  Ser Val Asn Cys Pro  Phe Ser Ser Gln Asp  Met Lys Tyr 
    1025                 1030                 1035             


Pro Ser  Pro Phe Phe Val Phe  Gly Glu Lys Ile Arg  Thr Arg Ala 
    1040                 1045                 1050             


Ile Ser  Ala Lys Gly Met Thr  Leu Val Thr Pro Leu  Gln Leu Leu 
    1055                 1060                 1065             


Leu Phe  Ala Ser Lys Lys Val  Gln Ser Asp Gly Gln  Ile Val Leu 
    1070                 1075                 1080             


Val Asp  Asp Trp Ile Lys Leu  Gln Ile Ser His Glu  Ala Ala Ala 
    1085                 1090                 1095             


Cys Ile  Thr Gly Leu Arg Ala  Ala Met Glu Ala Leu  Val Val Glu 
    1100                 1105                 1110             


Val Thr  Lys Gln Pro Ala Ile  Ile Ser Gln Leu Asp  Pro Val Asn 
    1115                 1120                 1125             


Glu Arg  Met Leu Asn Met Ile  Arg Gln Ile Ser Arg  Pro Ser Ala 
    1130                 1135                 1140             


Ala Gly  Ile Asn Leu Met Ile  Gly Ser Thr Arg Tyr  Gly Asp Gly 
    1145                 1150                 1155             


Pro Arg  Pro Pro Lys Met Ala  Arg Tyr Asp Asn Gly  Ser Gly Tyr 
    1160                 1165                 1170             


Arg Arg  Gly Gly Ser Ser Tyr  Ser Gly Gly Gly Tyr  Gly Gly Gly 
    1175                 1180                 1185             


Tyr Ser  Ser Gly Gly Tyr Gly  Ser Gly Gly Tyr Gly  Gly Ser Ala 
    1190                 1195                 1200             


Asn Ser  Phe Arg Ala Gly Tyr  Gly Ala Gly Val Gly  Gly Gly Tyr 
    1205                 1210                 1215             


Arg Gly  Val Ser Arg Gly Gly  Phe Arg Gly Asn Ser  Gly Gly Asp 
    1220                 1225                 1230             


Tyr Arg  Gly Pro Ser Gly Gly  Tyr Arg Gly Ser Gly  Gly Phe Gln 
    1235                 1240                 1245             


Arg Gly  Gly Gly Arg Gly Ala  Tyr Gly Thr Gly Tyr  Phe Gly Gln 
    1250                 1255                 1260             


Gly Arg  Gly Gly Gly Gly Tyr  
    1265                 1270 


<210>  6793
<211>  4415
<212>  DNA
<213>  Homosapiens

<400>  6793
gggggtgggg gaagggacga gccgcccgcg ggtccccgga ttgcgggttg cgtgcgcgcc     60

tcgccgcgat gcgcttgcgc cgtccgggca gcctgtggcc ccctcccctc tcctccgccc    120

agcgtttccc gctgctgcct ctagcaggca aagcgcgctt cctcctctgg cctgcgtacg    180

ccggggcacc gcggcggctg agggaagggg gtgcttcgcc tgtggtggtt gccgccgggg    240

cgccactggc ctagggctct tcattcattc aagccacgaa taactggcgc cgtcgtgcag    300

gccttgtggg tagaggaaaa aaaattgaag aatgtaaagg gagagcgcct ttggctagta    360

tagcgagatc tgaagaagac acttgaatca tgggtgacgt taaaaatttt ctgtatgcct    420

ggtgtggcaa aaggaagatg accccatcct atgaaattag agcagtgggg aacaaaaaca    480

ggcagaaatt catgtgtgag gttcaggtgg aaggttataa ttacactggc atgggaaatt    540

ccaccaataa aaaagatgca caaagcaatg ctgccagaga ctttgttaac tatttggttc    600

gaataaatga aataaagagt gaagaagttc cagcttttgg ggtagcatct ccgcccccac    660

ttactgatac tcctgacact acagcaaatg ctgaaggaga tttaccaaca accatgggag    720

gacctcttcc tccacatctg gctctcaaag cagaaaataa ttctgaggta ggggcctctg    780

gctatggtgt tcctgggccc acctgggacc gaggagccaa cttgaaggat tactactcaa    840

gaaaggaaga acaagaagtg caagcgactc tagaatcaga agaagtggat ttaaatgctg    900

ggcttcatgg aaactggacc ttggaaaatg ctaaagctcg tctaaaccaa tattttcaga    960

aagaaaagat ccaaggagaa tataagtaca cccaagtggg tcctgatcac aacaggagct   1020

ttattgcaga aatgaccatt tatatcaagc agctgggcag aaggattttt gcacgagaac   1080

atggatcaaa taagaaattg gcagcacagt cctgtgccct gtcacttgtc agacaactgt   1140

accatcttgg agtggttgaa gcttactccg gacttacaaa gaagaaggaa ggagagacag   1200

tggagcctta caaagtaaac ctctctcaag atttagagca tcagctgcaa aacatcattc   1260

aagagctaaa tcttgagatt ttgcccccgc ctgaagatcc ttctgtgcca gttgcactca   1320

acattggcaa attggctcag ttcgaaccat ctcagcgaca aaaccaagtg ggtgtggttc   1380

cttggtcacc tccacaatcc aactggaatc cttggactag tagcaacatt gatgaggggc   1440

ctctggcttt tgctactcca gagcaaataa gcatggacct caagaatgaa ttgatgtacc   1500

agttggaaca ggatcatgat ttgcaagcaa tcttgcagga gagagagtta ctgcctgtga   1560

agaaatttga aagtgagatt ctggaagcaa tcagccaaaa ttcagttgtc attattagag   1620

gggctactgg atgtgggaaa accacacagg ttccccagtt cattctagat gactttatcc   1680

agaatgaccg agcagcagag tgtaacatcg tagtaactca gcccagaaga atcagtgcgg   1740

tttctgtggc agagcgagtt gcatttgaaa gaggagaaga gcctggaaaa agctgtggct   1800

acagcgttcg atttgagtct atacttcctc gtcctcatgc cagtataatg ttttgtactg   1860

taggtgtgct cctgagaaaa ttagaagcag gcattcgagg aatcagtcat gtaattgtag   1920

atgaaataca tgaaagagat attaatactg acttcctttt ggtagtactg cgtgatgttg   1980

ttcaggctta tcctgaagtt cgcattgttc ttatgtctgc tactattgat accagcatgt   2040

tttgtgaata tttcttcaat tgccccatca ttgaagttta tgggaggact tacccagttc   2100

aagaatattt tctggaagac tgcattcaga tgacccactt tgttcctcca ccaaaagaca   2160

aaaagaagaa ggataaggat gatgatggtg gtgaggatga tgatgcaaat tgcaacttga   2220

tctgtggtga tgaatatggt ccagaaacaa ggttgagcat gtctcaattg aacgaaaagg   2280

aaactccttt tgaactcatc gaggctctac ttaagtacat tgaaaccctt aatgttcctg   2340

gagctgtgtt ggtttttttg cctggctgga atctgattta tactatgcag aagcatttgg   2400

aaatgaatcc acattttgga agccatcggt atcagattct acccctgcat tctcagattc   2460

ctcgagagga acagcgcaaa gtgtttgatc cagtaccagt tggagtaacc aaggttattt   2520

tgtccacaaa tattgctgaa acaagcatta ccataaacga tgttgtttat gtcattgact   2580

cctgcaagca gaaagtgaaa ctcttcactg ctcacaacaa tatgaccaac tatgctaccg   2640

tatgggcatc aaaaacaaac cttgagcaac ggaaagggcg agctggccga gtacggcctg   2700

gattctgctt tcacctgtgc agccgagctc gttttgagag acttgaaacc cacatgacac   2760

cagagatgtt ccgaacacca ttgcatgaaa ttgctcttag cataaaactt ctgcgtctag   2820

gaggaattgg ccaatttctg gccaaagcaa ttgaacctcc ccctttggat gctgtgattg   2880

aagcagaaca cactcttaga gagcttgatg cattagatgc caatgatgag ttgactcctt   2940

tgggacgaat cctggctaaa ctccccattg agcctcgttt tggcaaaatg atgataatgg   3000

ggtgtatttt ctacgtggga gatgctatct gtaccattgc tgctgctacc tgctttccag   3060

agcctttcat caatgaagga aagcggctgg gctatatcca tcgaaatttt gctggaaaca   3120

gattttctga tcacgtagcc cttttatcag tattccaagc ctgggatgat gctagaatgg   3180

gtggagaaga agcagagata cgtttttgtg agcacaaaag acttaatatg gctacactaa   3240

gaatgacttg ggaagccaaa gttcagctca aagagatttt gattaattct gggtttccag   3300

aagattgttt gttgacacaa gtgtttacta acactggacc agataataat ttggatgttg   3360

ttatctccct cctggccttt gtagccaaga catgaagtac ccatctccct tctttgtatt   3420

tggtgaaaag attcgaactc gagccatctc tgctaaaggc atgactttag tcacccccct   3480

gcagttgctt ctctttgcct ccaagaaagt ccaatctgat gggcagattg tgcttgtaga   3540

tgactggatt aaactgcaaa tatctcatga agctgctgcc tgtatcactg gtctccgggc   3600

agccatggag gctttggttg ttgaagtaac caaacaacct gctatcatca gccagttgga   3660

ccccgtaaat gaacgtatgc tgaacatgat ccgtcagatc tctagaccct cagctgctgg   3720

tatcaacctt atgattggca gtacacggta tggagatggt ccacgtcctc ccaagatggc   3780

ccgatacgac aatggaagcg gatatagaag gggaggttct agttacagtg gtggaggcta   3840

tggcggtggc tatagcagtg gaggctatgg tagcggaggc tatggtggca gcgccaactc   3900

ctttcgggca ggatatggtg caggtgttgg tggaggctat agaggagttt cccgaggtgg   3960

ctttagaggc aactctggag gagactacag agggcctagt ggaggctaca gaggatctgg   4020

gggattccag cgaggaggtg gtaggggggc ctatggaact ggctactttg gacagggaag   4080

aggaggtggc ggctattaaa acttggttat gtcagttcct gtgtgtagac agtaaggaaa   4140

aaaaggcatg ctatgtgtta cgtgtttttt ccagtatgtt tatttgccac caaaaagtaa   4200

atgcattttc acccattctg tggttcattg tagtttaagg aaaccaagca tatagatgca   4260

ttagtgattt tgtttatatt atgtaaaata taacgatctc ttaaaaatac cacagtttgt   4320

attttttctt taaggagtaa agatttgcct ttaaataact tggtattttc ctggctttcg   4380

tttaatacaa tagaaaataa agtattacac cgaat                              4415


<210>  6794
<211>  1001
<212>  PRT
<213>  Homosapiens

<400>  6794

Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys 
1               5                   10                  15      


Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln 
            20                  25                  30          


Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met 
        35                  40                  45              


Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp 
    50                  55                  60                  


Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val 
65                  70                  75                  80  


Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp 
                85                  90                  95      


Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro 
            100                 105                 110         


Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly 
        115                 120                 125             


Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn 
    130                 135                 140                 


Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr 
145                 150                 155                 160 


Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp 
                165                 170                 175     


Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu 
            180                 185                 190         


Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn 
        195                 200                 205             


Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg 
    210                 215                 220                 


Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln 
225                 230                 235                 240 


Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val 
                245                 250                 255     


Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu 
            260                 265                 270         


Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn 
        275                 280                 285             


Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro 
    290                 295                 300                 


Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro 
305                 310                 315                 320 


Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln 
                325                 330                 335     


Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu 
            340                 345                 350         


Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu 
        355                 360                 365             


Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu 
    370                 375                 380                 


Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala 
385                 390                 395                 400 


Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly 
                405                 410                 415     


Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn 
            420                 425                 430         


Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile 
        435                 440                 445             


Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu 
    450                 455                 460                 


Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro 
465                 470                 475                 480 


Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg 
                485                 490                 495     


Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu 
            500                 505                 510         


Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg 
        515                 520                 525             


Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala 
    530                 535                 540                 


Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile 
545                 550                 555                 560 


Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu 
                565                 570                 575     


Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys 
            580                 585                 590         


Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys 
        595                 600                 605             


Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met 
    610                 615                 620                 


Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu 
625                 630                 635                 640 


Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe 
                645                 650                 655     


Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met 
            660                 665                 670         


Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser 
        675                 680                 685             


Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val 
    690                 695                 700                 


Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile 
705                 710                 715                 720 


Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val 
                725                 730                 735     


Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr Val Trp 
            740                 745                 750         


Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Val 
        755                 760                 765             


Arg Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg 
    770                 775                 780                 


Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu 
785                 790                 795                 800 


Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe 
                805                 810                 815     


Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala 
            820                 825                 830         


Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu 
        835                 840                 845             


Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe 
    850                 855                 860                 


Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile 
865                 870                 875                 880 


Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu 
                885                 890                 895     


Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe 
            900                 905                 910         


Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala 
        915                 920                 925             


Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg 
    930                 935                 940                 


Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu 
945                 950                 955                 960 


Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr 
                965                 970                 975     


Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile 
            980                 985                 990         


Ser Leu Leu Ala Phe Val Ala Lys  Thr 
        995                 1000     


<210>  6795
<211>  4647
<212>  DNA
<213>  Homosapiens

<400>  6795
gggggtgggg gaagggacga gccgcccgcg ggtccccgga ttgcgggttg cgtgcgcgcc     60

tcgccgcgat gcgcttgcgc cgtccgggca gcctgtggcc ccctcccctc tcctccgccc    120

agcgtttccc gctgctgcct ctagcaggca aagcgcgctt cctcctctgg cctgcgtacg    180

ccggggcacc gcggcggctg agggaagggg gtgcttcgcc tgtggtggtt gccgccgggg    240

cgccactggc ctagggctct tcattcattc aagccacgaa taactggcgc cgtcgtgcag    300

gccttgtggg tagaggaaaa aaaattgaag aatgtaaagg gagagcgcct ttggctagta    360

tagcgagatc tgaagaagac acttgaatca tgggtgacgt taaaaatttt ctgtatgcct    420

ggtgtggcaa aaggaagatg accccatcct atgaaattag agcagtgggg aacaaaaaca    480

ggcagaaatt catgtgtgag gttcaggtgg aaggttataa ttacactggc atgggaaatt    540

ccaccaataa aaaagatgca caaagcaatg ctgccagaga ctttgttaac tatttggttc    600

gaataaatga aataaagagt gaagaagttc cagcttttgg ggtagcatct ccgcccccac    660

ttactgatac tcctgacact acagcaaatg ctgaaggaga tttaccaaca accatgggag    720

gacctcttcc tccacatctg gctctcaaag cagaaaataa ttctgaggta ggggcctctg    780

gctatggtgt tcctgggccc acctgggacc gaggagccaa cttgaaggat tactactcaa    840

gaaaggaaga acaagaagtg caagcgactc tagaatcaga agaagtggat ttaaatgctg    900

ggcttcatgg aaactggacc ttggaaaatg ctaaagctcg tctaaaccaa tattttcaga    960

aagaaaagat ccaaggagaa tataagtaca cccaagtggg tcctgatcac aacaggagct   1020

ttattgcaga aatgaccatt tatatcaagc agctgggcag aaggattttt gcacgagaac   1080

atggatcaaa taagaaattg gcagcacagt cctgtgccct gtcacttgtc agacaactgt   1140

accatcttgg agtggttgaa gcttactccg gacttacaaa gaagaaggaa ggagagacag   1200

tggagcctta caaagtaaac ctctctcaag atttagagca tcagctgcaa aacatcattc   1260

aagagctaaa tcttgagatt ttgcccccgc ctgaagatcc ttctgtgcca gttgcactca   1320

acattggcaa attggctcag ttcgaaccat ctcagcgaca aaaccaagtg ggtgtggttc   1380

cttggtcacc tccacaatcc aactggaatc cttggactag tagcaacatt gatgaggggc   1440

ctctggcttt tgctactcca gagcaaataa gcatggacct caagaatgaa ttgatgtacc   1500

agttggaaca ggatcatgat ttgcaagcaa tcttgcagga gagagagtta ctgcctgtga   1560

agaaatttga aagtgagatt ctggaagcaa tcagccaaaa ttcagttgtc attattagag   1620

gggctactgg atgtgggaaa accacacagg ttccccagtt cattctagat gactttatcc   1680

agaatgaccg agcagcagag tgtaacatcg tagtaactca gcccagaaga atcagtgcgg   1740

tttctgtggc agagcgagtt gcatttgaaa gaggagaaga gcctggaaaa agctgtggct   1800

acagcgttcg atttgagtct atacttcctc gtcctcatgc cagtataatg ttttgtactg   1860

taggtgtgct cctgagaaaa ttagaagcag gcattcgagg aatcagtcat gtaattgtag   1920

atgaaataca tgaaagagat attaatactg acttcctttt ggtagtactg cgtgatgttg   1980

ttcaggctta tcctgaagtt cgcattgttc ttatgtctgc tactattgat accagcatgt   2040

tttgtgaata tttcttcaat tgccccatca ttgaagttta tgggaggact tacccagttc   2100

aagaatattt tctggaagac tgcattcaga tgacccactt tgttcctcca ccaaaagaca   2160

aaaagaagaa ggataaggat gatgatggtg gtgaggatga tgatgcaaat tgcaacttga   2220

tctgtggtga tgaatatggt ccagaaacaa ggttgagcat gtctcaattg aacgaaaagg   2280

aaactccttt tgaactcatc gaggctctac ttaagtacat tgaaaccctt aatgttcctg   2340

gagctgtgtt ggtttttttg cctggctgga atctgattta tactatgcag aagcatttgg   2400

aaatgaatcc acattttgga agccatcggt atcagattct acccctgcat tctcagattc   2460

ctcgagagga acagcgcaaa gtgtttgatc cagtaccagt tggagtaacc aaggttattt   2520

tgtccacaaa tattgctgaa acaagcatta ccataaacga tgttgtttat gtcattgact   2580

cctgcaagca gaaagtgaaa ctcttcactg ctcacaacaa tatgaccaac tatgctaccg   2640

tatgggcatc aaaaacaaac cttgagcaac ggaaagggcg agctggccga gtacggcctg   2700

gattctgctt tcacctgtgc agccgagctc gttttgagag acttgaaacc cacatgacac   2760

cagagatgtt ccgaacacca ttgcatgaaa ttgctcttag cataaaactt ctgcgtctag   2820

gaggaattgg ccaatttctg gccaaagcaa ttgaacctcc ccctttggat gctgtgattg   2880

aagcagaaca cactcttaga gagcttgatg cattagatgc caatgatgag ttgactcctt   2940

tgggacgaat cctggctaaa ctccccattg agcctcgttt tggcaaaatg atgataatgg   3000

ggtgtatttt ctacgtggga gatgctatct gtaccattgc tgctgctacc tgctttccag   3060

agcctttcat caatgaagga aagcggctgg gctatatcca tcgaaatttt gctggaaaca   3120

gattttctga tcacgtagcc cttttatcag tattccaagc ctgggatgat gctagaatgg   3180

gtggagaaga agcagagata cgtttttgtg agcacaaaag acttaatatg gctacactaa   3240

gaatgacttg ggaagccaaa gttcagctca aagagatttt gattaattct gggtttccag   3300

aagattgttt gttgacacaa gtgtttacta acactggacc agataataat ttggatgttg   3360

ttatctccct cctggccttt gtagccaaga catgaagtac ccatctccct tctttgtatt   3420

tggtgaaaag attcgaactc gagccatctc tgctaaaggc atgactttag tcacccccct   3480

gcagttgctt ctctttgcct ccaagaaagt ccaatctgat gggcagattg tgcttgtaga   3540

tgactggatt aaactgcaaa tatctcatga agctgctgcc tgtatcactg gtctccgggc   3600

agccatggag gctttggttg ttgaagtaac caaacaacct gctatcatca gccagttgga   3660

ccccgtaaat gaacgtatgc tgaacatgat ccgtcagatc tctagaccct cagctgctgg   3720

tatcaacctt atgattggca gtacacggta tggagatggt ccacgtcctc ccaagatggc   3780

ccgatacgac aatggaagcg gatatagaag gggaggttct agttacagtg gtggaggcta   3840

tggcggtggc tatagcagtg gaggctatgg tagcggaggc tatggtggca gcgccaactc   3900

ctttcgggca ggatatggtg caggtgttgg tggaggctat agaggagttt cccgaggtgg   3960

ctttagaggc aactctggag gagactacag agggcctagt ggaggctaca gaggatctgg   4020

gggattccag cgaggaggtg gtaggggggc ctatggaact ggctactttg gacagggaag   4080

aggaggtggc ggctattaaa acttggttat gtcagttcct gtgtgtagac agtaaggaaa   4140

aaaaggcatg ctatgtgtta cgtgtttttt ccagtatgtt tatttgccac caaaaagtaa   4200

atgcattttc acccattctg tggttcattg tagtttaagg aaaccaagca tatagatgca   4260

ttagtgattt tgtttatatt atgtaaaata taacgatctc ttaaaaatac cacagtttgt   4320

attttttctt taaggagtaa agatttgcct ttaaataact tggtattttc ctggctttcg   4380

tttaatacaa tagaaaataa agtattacac cgaatacttg ccgtgtagtt tgtttgttga   4440

cctcgtatgt tagaaaattt tacaatgcca gctacatctg ttgattttaa atgtcagaga   4500

agttgtaccc tgtttcaaaa gtatactaag tgatactact tgtaatagaa taaatcatct   4560

tggaattgaa ttgttacctt ttgaagtaaa tactggcaag tgcacaagcc acataaacct   4620

gaataaaact tttgacctag ggttgaa                                       4647


<210>  6796
<211>  1001
<212>  PRT
<213>  Homosapiens

<400>  6796

Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys 
1               5                   10                  15      


Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln 
            20                  25                  30          


Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met 
        35                  40                  45              


Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp 
    50                  55                  60                  


Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val 
65                  70                  75                  80  


Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp 
                85                  90                  95      


Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro 
            100                 105                 110         


Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly 
        115                 120                 125             


Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn 
    130                 135                 140                 


Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr 
145                 150                 155                 160 


Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp 
                165                 170                 175     


Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu 
            180                 185                 190         


Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn 
        195                 200                 205             


Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg 
    210                 215                 220                 


Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln 
225                 230                 235                 240 


Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val 
                245                 250                 255     


Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu 
            260                 265                 270         


Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn 
        275                 280                 285             


Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro 
    290                 295                 300                 


Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro 
305                 310                 315                 320 


Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln 
                325                 330                 335     


Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu 
            340                 345                 350         


Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu 
        355                 360                 365             


Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu 
    370                 375                 380                 


Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala 
385                 390                 395                 400 


Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly 
                405                 410                 415     


Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn 
            420                 425                 430         


Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile 
        435                 440                 445             


Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu 
    450                 455                 460                 


Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro 
465                 470                 475                 480 


Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg 
                485                 490                 495     


Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu 
            500                 505                 510         


Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg 
        515                 520                 525             


Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala 
    530                 535                 540                 


Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile 
545                 550                 555                 560 


Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu 
                565                 570                 575     


Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys 
            580                 585                 590         


Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys 
        595                 600                 605             


Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met 
    610                 615                 620                 


Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu 
625                 630                 635                 640 


Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe 
                645                 650                 655     


Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met 
            660                 665                 670         


Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser 
        675                 680                 685             


Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val 
    690                 695                 700                 


Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile 
705                 710                 715                 720 


Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val 
                725                 730                 735     


Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr Val Trp 
            740                 745                 750         


Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Val 
        755                 760                 765             


Arg Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg 
    770                 775                 780                 


Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu 
785                 790                 795                 800 


Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe 
                805                 810                 815     


Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala 
            820                 825                 830         


Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu 
        835                 840                 845             


Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe 
    850                 855                 860                 


Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile 
865                 870                 875                 880 


Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu 
                885                 890                 895     


Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe 
            900                 905                 910         


Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala 
        915                 920                 925             


Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg 
    930                 935                 940                 


Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu 
945                 950                 955                 960 


Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr 
                965                 970                 975     


Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile 
            980                 985                 990         


Ser Leu Leu Ala Phe Val Ala Lys  Thr 
        995                 1000     


<210>  6797
<211>  2764
<212>  DNA
<213>  Homosapiens

<400>  6797
caaaaatgct aataaacaag tatatctaac tttgtagttg ttaagtcact tttctttttt     60

tctgtctcag cccagaagaa tcagtgcggt ttctgtggca gagcgagttg catttgaaag    120

aggagaagag cctggaaaaa gctgtggcta cagcgttcga tttgagtcta tacttcctcg    180

tcctcatgcc agtataatgt tttgtactgt aggtgtgctc ctgagaaaat tagaagcagg    240

cattcgagga atcagtcatg taattgtaga tgaaatacat gaaagagata ttaatactga    300

cttccttttg gtagtactgc gtgatgttgt tcaggcttat cctgaagttc gcattgttct    360

tatgtctgct actattgata ccagcatgtt ttgtgaatat ttcttcaatt gccccatcat    420

tgaagtttat gggaggactt acccagttca agaatatttt ctggaagact gcattcagat    480

gacccacttt gttcctccac caaaagacaa aaagaagaag gataaggatg atgatggtgg    540

tgaggatgat gatgcaaatt gcaacttgat ctgtggtgat gaatatggtc cagaaacaag    600

gttgagcatg tctcaattga acgaaaagga aactcctttt gaactcatcg aggctctact    660

taagtacatt gaaaccctta atgttcctgg agctgtgttg gtttttttgc ctggctggaa    720

tctgatttat actatgcaga agcatttgga aatgaatcca cattttggaa gccatcggta    780

tcagattcta cccctgcatt ctcagattcc tcgagaggaa cagcgcaaag tgtttgatcc    840

agtaccagtt ggagtaacca aggttatttt gtccacaaat attgctgaaa caagcattac    900

cataaacgat gttgtttatg tcattgactc ctgcaagcag aaagtgaaac tcttcactgc    960

tcacaacaat atgaccaact atgctaccgt atgggcatca aaaacaaacc ttgagcaacg   1020

gaaagggcga gctggccgag tacggcctgg attctgcttt cacctgtgca gccgagctcg   1080

ttttgagaga cttgaaaccc acatgacacc agagatgttc cgaacaccat tgcatgaaat   1140

tgctcttagc ataaaacttc tgcgtctagg aggaattggc caatttctgg ccaaagcaat   1200

tgaacctccc cctttggatg ctgtgattga agcagaacac actcttagag agcttgatgc   1260

attagatgcc aatgatgagt tgactccttt gggacgaatc ctggctaaac tccccattga   1320

gcctcgtttt ggcaaaatga tgataatggg gtgtattttc tacgtgggag atgctatctg   1380

taccattgct gctgctacct gctttccaga gcctttcatc aatgaaggaa agcggctggg   1440

ctatatccat cgaaattttg ctggaaacag attttctgat cacgtagccc ttttatcagt   1500

attccaagcc tgggatgatg ctagaatggg tggagaagaa gcagagatac gtttttgtga   1560

gcacaaaaga cttaatatgg ctacactaag aatgacttgg gaagccaaag ttcagctcaa   1620

agagattttg attaattctg ggtttccaga agattgtttg ttgacacaag tgtttactaa   1680

cactggacca gataataatt tggatgttgt tatctccctc ctggcctttg tagccaagac   1740

atgaagtacc catctccctt ctttgtattt ggtgaaaaga ttcgaactcg agccatctct   1800

gctaaaggca tgactttagt cacccccctg cagttgcttc tctttgcctc caagaaagtc   1860

caatctgatg ggcagattgt gcttgtagat gactggatta aactgcaaat atctcatgaa   1920

gctgctgcct gtatcactgg tctccgggca gccatggagg ctttggttgt tgaagtaacc   1980

aaacaacctg ctatcatcag ccagttggac cccgtaaatg aacgtatgct gaacatgatc   2040

cgtcagatct ctagaccctc agctgctggt atcaacctta tgattggcag tacacggtat   2100

ggagatggtc cacgtcctcc caagatggcc cgatacgaca atggaagcgg atatagaagg   2160

ggaggttcta gttacagtgg tggaggctat ggcggtggct atagcagtgg aggctatggt   2220

agcggaggct atggtggcag cgccaactcc tttcgggcag gatatggtgc aggtgttggt   2280

ggaggctata gaggagtttc ccgaggtggc tttagaggca actctggagg agactacaga   2340

gggcctagtg gaggctacag aggatctggg ggattccagc gaggaggtgg taggggggcc   2400

tatggaactg gctactttgg acagggaaga ggaggtggcg gctattaaaa cttggttatg   2460

tcagttcctg tgtgtagaca gtaaggaaaa aaaggcatgc tatgtgttac gtgttttttc   2520

cagtatgttt atttgccacc aaaaagtaaa tgcattttca cccattctgt ggttcattgt   2580

agtttaagga aaccaagcat atagatgcat tagtgatttt gtttatatta tgtaaaatat   2640

aacgatctct taaaaatacc acagtttgta ttttttcttt aaggagtaaa gatttgcctt   2700

taaataactt ggtattttcc tggctttcgt ttaatacaat agaaaataaa gtattacacc   2760

gaat                                                                2764


<210>  6798
<211>  515
<212>  PRT
<213>  Homosapiens

<400>  6798

Met Phe Cys Thr Val Gly Val Leu Leu Arg Lys Leu Glu Ala Gly Ile 
1               5                   10                  15      


Arg Gly Ile Ser His Val Ile Val Asp Glu Ile His Glu Arg Asp Ile 
            20                  25                  30          


Asn Thr Asp Phe Leu Leu Val Val Leu Arg Asp Val Val Gln Ala Tyr 
        35                  40                  45              


Pro Glu Val Arg Ile Val Leu Met Ser Ala Thr Ile Asp Thr Ser Met 
    50                  55                  60                  


Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile Ile Glu Val Tyr Gly Arg 
65                  70                  75                  80  


Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu Asp Cys Ile Gln Met Thr 
                85                  90                  95      


His Phe Val Pro Pro Pro Lys Asp Lys Lys Lys Lys Asp Lys Asp Asp 
            100                 105                 110         


Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys Asn Leu Ile Cys Gly Asp 
        115                 120                 125             


Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met Ser Gln Leu Asn Glu Lys 
    130                 135                 140                 


Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu Leu Lys Tyr Ile Glu Thr 
145                 150                 155                 160 


Leu Asn Val Pro Gly Ala Val Leu Val Phe Leu Pro Gly Trp Asn Leu 
                165                 170                 175     


Ile Tyr Thr Met Gln Lys His Leu Glu Met Asn Pro His Phe Gly Ser 
            180                 185                 190         


His Arg Tyr Gln Ile Leu Pro Leu His Ser Gln Ile Pro Arg Glu Glu 
        195                 200                 205             


Gln Arg Lys Val Phe Asp Pro Val Pro Val Gly Val Thr Lys Val Ile 
    210                 215                 220                 


Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile Thr Ile Asn Asp Val Val 
225                 230                 235                 240 


Tyr Val Ile Asp Ser Cys Lys Gln Lys Val Lys Leu Phe Thr Ala His 
                245                 250                 255     


Asn Asn Met Thr Asn Tyr Ala Thr Val Trp Ala Ser Lys Thr Asn Leu 
            260                 265                 270         


Glu Gln Arg Lys Gly Arg Ala Gly Arg Val Arg Pro Gly Phe Cys Phe 
        275                 280                 285             


His Leu Cys Ser Arg Ala Arg Phe Glu Arg Leu Glu Thr His Met Thr 
    290                 295                 300                 


Pro Glu Met Phe Arg Thr Pro Leu His Glu Ile Ala Leu Ser Ile Lys 
305                 310                 315                 320 


Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe Leu Ala Lys Ala Ile Glu 
                325                 330                 335     


Pro Pro Pro Leu Asp Ala Val Ile Glu Ala Glu His Thr Leu Arg Glu 
            340                 345                 350         


Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu Thr Pro Leu Gly Arg Ile 
        355                 360                 365             


Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe Gly Lys Met Met Ile Met 
    370                 375                 380                 


Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile Cys Thr Ile Ala Ala Ala 
385                 390                 395                 400 


Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu Gly Lys Arg Leu Gly Tyr 
                405                 410                 415     


Ile His Arg Asn Phe Ala Gly Asn Arg Phe Ser Asp His Val Ala Leu 
            420                 425                 430         


Leu Ser Val Phe Gln Ala Trp Asp Asp Ala Arg Met Gly Gly Glu Glu 
        435                 440                 445             


Ala Glu Ile Arg Phe Cys Glu His Lys Arg Leu Asn Met Ala Thr Leu 
    450                 455                 460                 


Arg Met Thr Trp Glu Ala Lys Val Gln Leu Lys Glu Ile Leu Ile Asn 
465                 470                 475                 480 


Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr Gln Val Phe Thr Asn Thr 
                485                 490                 495     


Gly Pro Asp Asn Asn Leu Asp Val Val Ile Ser Leu Leu Ala Phe Val 
            500                 505                 510         


Ala Lys Thr 
        515 


<210>  6799
<211>  2996
<212>  DNA
<213>  Homosapiens

<400>  6799
caaaaatgct aataaacaag tatatctaac tttgtagttg ttaagtcact tttctttttt     60

tctgtctcag cccagaagaa tcagtgcggt ttctgtggca gagcgagttg catttgaaag    120

aggagaagag cctggaaaaa gctgtggcta cagcgttcga tttgagtcta tacttcctcg    180

tcctcatgcc agtataatgt tttgtactgt aggtgtgctc ctgagaaaat tagaagcagg    240

cattcgagga atcagtcatg taattgtaga tgaaatacat gaaagagata ttaatactga    300

cttccttttg gtagtactgc gtgatgttgt tcaggcttat cctgaagttc gcattgttct    360

tatgtctgct actattgata ccagcatgtt ttgtgaatat ttcttcaatt gccccatcat    420

tgaagtttat gggaggactt acccagttca agaatatttt ctggaagact gcattcagat    480

gacccacttt gttcctccac caaaagacaa aaagaagaag gataaggatg atgatggtgg    540

tgaggatgat gatgcaaatt gcaacttgat ctgtggtgat gaatatggtc cagaaacaag    600

gttgagcatg tctcaattga acgaaaagga aactcctttt gaactcatcg aggctctact    660

taagtacatt gaaaccctta atgttcctgg agctgtgttg gtttttttgc ctggctggaa    720

tctgatttat actatgcaga agcatttgga aatgaatcca cattttggaa gccatcggta    780

tcagattcta cccctgcatt ctcagattcc tcgagaggaa cagcgcaaag tgtttgatcc    840

agtaccagtt ggagtaacca aggttatttt gtccacaaat attgctgaaa caagcattac    900

cataaacgat gttgtttatg tcattgactc ctgcaagcag aaagtgaaac tcttcactgc    960

tcacaacaat atgaccaact atgctaccgt atgggcatca aaaacaaacc ttgagcaacg   1020

gaaagggcga gctggccgag tacggcctgg attctgcttt cacctgtgca gccgagctcg   1080

ttttgagaga cttgaaaccc acatgacacc agagatgttc cgaacaccat tgcatgaaat   1140

tgctcttagc ataaaacttc tgcgtctagg aggaattggc caatttctgg ccaaagcaat   1200

tgaacctccc cctttggatg ctgtgattga agcagaacac actcttagag agcttgatgc   1260

attagatgcc aatgatgagt tgactccttt gggacgaatc ctggctaaac tccccattga   1320

gcctcgtttt ggcaaaatga tgataatggg gtgtattttc tacgtgggag atgctatctg   1380

taccattgct gctgctacct gctttccaga gcctttcatc aatgaaggaa agcggctggg   1440

ctatatccat cgaaattttg ctggaaacag attttctgat cacgtagccc ttttatcagt   1500

attccaagcc tgggatgatg ctagaatggg tggagaagaa gcagagatac gtttttgtga   1560

gcacaaaaga cttaatatgg ctacactaag aatgacttgg gaagccaaag ttcagctcaa   1620

agagattttg attaattctg ggtttccaga agattgtttg ttgacacaag tgtttactaa   1680

cactggacca gataataatt tggatgttgt tatctccctc ctggcctttg tagccaagac   1740

atgaagtacc catctccctt ctttgtattt ggtgaaaaga ttcgaactcg agccatctct   1800

gctaaaggca tgactttagt cacccccctg cagttgcttc tctttgcctc caagaaagtc   1860

caatctgatg ggcagattgt gcttgtagat gactggatta aactgcaaat atctcatgaa   1920

gctgctgcct gtatcactgg tctccgggca gccatggagg ctttggttgt tgaagtaacc   1980

aaacaacctg ctatcatcag ccagttggac cccgtaaatg aacgtatgct gaacatgatc   2040

cgtcagatct ctagaccctc agctgctggt atcaacctta tgattggcag tacacggtat   2100

ggagatggtc cacgtcctcc caagatggcc cgatacgaca atggaagcgg atatagaagg   2160

ggaggttcta gttacagtgg tggaggctat ggcggtggct atagcagtgg aggctatggt   2220

agcggaggct atggtggcag cgccaactcc tttcgggcag gatatggtgc aggtgttggt   2280

ggaggctata gaggagtttc ccgaggtggc tttagaggca actctggagg agactacaga   2340

gggcctagtg gaggctacag aggatctggg ggattccagc gaggaggtgg taggggggcc   2400

tatggaactg gctactttgg acagggaaga ggaggtggcg gctattaaaa cttggttatg   2460

tcagttcctg tgtgtagaca gtaaggaaaa aaaggcatgc tatgtgttac gtgttttttc   2520

cagtatgttt atttgccacc aaaaagtaaa tgcattttca cccattctgt ggttcattgt   2580

agtttaagga aaccaagcat atagatgcat tagtgatttt gtttatatta tgtaaaatat   2640

aacgatctct taaaaatacc acagtttgta ttttttcttt aaggagtaaa gatttgcctt   2700

taaataactt ggtattttcc tggctttcgt ttaatacaat agaaaataaa gtattacacc   2760

gaatacttgc cgtgtagttt gtttgttgac ctcgtatgtt agaaaatttt acaatgccag   2820

ctacatctgt tgattttaaa tgtcagagaa gttgtaccct gtttcaaaag tatactaagt   2880

gatactactt gtaatagaat aaatcatctt ggaattgaat tgttaccttt tgaagtaaat   2940

actggcaagt gcacaagcca cataaacctg aataaaactt ttgacctagg gttgaa       2996


<210>  6800
<211>  515
<212>  PRT
<213>  Homosapiens

<400>  6800

Met Phe Cys Thr Val Gly Val Leu Leu Arg Lys Leu Glu Ala Gly Ile 
1               5                   10                  15      


Arg Gly Ile Ser His Val Ile Val Asp Glu Ile His Glu Arg Asp Ile 
            20                  25                  30          


Asn Thr Asp Phe Leu Leu Val Val Leu Arg Asp Val Val Gln Ala Tyr 
        35                  40                  45              


Pro Glu Val Arg Ile Val Leu Met Ser Ala Thr Ile Asp Thr Ser Met 
    50                  55                  60                  


Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile Ile Glu Val Tyr Gly Arg 
65                  70                  75                  80  


Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu Asp Cys Ile Gln Met Thr 
                85                  90                  95      


His Phe Val Pro Pro Pro Lys Asp Lys Lys Lys Lys Asp Lys Asp Asp 
            100                 105                 110         


Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys Asn Leu Ile Cys Gly Asp 
        115                 120                 125             


Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met Ser Gln Leu Asn Glu Lys 
    130                 135                 140                 


Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu Leu Lys Tyr Ile Glu Thr 
145                 150                 155                 160 


Leu Asn Val Pro Gly Ala Val Leu Val Phe Leu Pro Gly Trp Asn Leu 
                165                 170                 175     


Ile Tyr Thr Met Gln Lys His Leu Glu Met Asn Pro His Phe Gly Ser 
            180                 185                 190         


His Arg Tyr Gln Ile Leu Pro Leu His Ser Gln Ile Pro Arg Glu Glu 
        195                 200                 205             


Gln Arg Lys Val Phe Asp Pro Val Pro Val Gly Val Thr Lys Val Ile 
    210                 215                 220                 


Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile Thr Ile Asn Asp Val Val 
225                 230                 235                 240 


Tyr Val Ile Asp Ser Cys Lys Gln Lys Val Lys Leu Phe Thr Ala His 
                245                 250                 255     


Asn Asn Met Thr Asn Tyr Ala Thr Val Trp Ala Ser Lys Thr Asn Leu 
            260                 265                 270         


Glu Gln Arg Lys Gly Arg Ala Gly Arg Val Arg Pro Gly Phe Cys Phe 
        275                 280                 285             


His Leu Cys Ser Arg Ala Arg Phe Glu Arg Leu Glu Thr His Met Thr 
    290                 295                 300                 


Pro Glu Met Phe Arg Thr Pro Leu His Glu Ile Ala Leu Ser Ile Lys 
305                 310                 315                 320 


Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe Leu Ala Lys Ala Ile Glu 
                325                 330                 335     


Pro Pro Pro Leu Asp Ala Val Ile Glu Ala Glu His Thr Leu Arg Glu 
            340                 345                 350         


Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu Thr Pro Leu Gly Arg Ile 
        355                 360                 365             


Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe Gly Lys Met Met Ile Met 
    370                 375                 380                 


Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile Cys Thr Ile Ala Ala Ala 
385                 390                 395                 400 


Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu Gly Lys Arg Leu Gly Tyr 
                405                 410                 415     


Ile His Arg Asn Phe Ala Gly Asn Arg Phe Ser Asp His Val Ala Leu 
            420                 425                 430         


Leu Ser Val Phe Gln Ala Trp Asp Asp Ala Arg Met Gly Gly Glu Glu 
        435                 440                 445             


Ala Glu Ile Arg Phe Cys Glu His Lys Arg Leu Asn Met Ala Thr Leu 
    450                 455                 460                 


Arg Met Thr Trp Glu Ala Lys Val Gln Leu Lys Glu Ile Leu Ile Asn 
465                 470                 475                 480 


Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr Gln Val Phe Thr Asn Thr 
                485                 490                 495     


Gly Pro Asp Asn Asn Leu Asp Val Val Ile Ser Leu Leu Ala Phe Val 
            500                 505                 510         


Ala Lys Thr 
        515 


<210>  6801
<211>  1962
<212>  DNA
<213>  Homosapiens

<400>  6801
gggaaaccta tttgtctgct ccagtgttac taactggaaa cttcttacca gttaacagaa     60

tcaaaaacac cttattttta aactcctgtg ttcttaaatc tccaaaatta ttgtgcatct    120

atatagcatt ataggcagaa agtgaaactc ttcactgctc acaacaatat gaccaactat    180

gctaccgtat gggcatcaaa aacaaacctt gagcaacgga aagggcgagc tggccgagta    240

cggcctggat tctgctttca cctgtgcagc cgagctcgtt ttgagagact tgaaacccac    300

atgacaccag agatgttccg aacaccattg catgaaattg ctcttagcat aaaacttctg    360

cgtctaggag gaattggcca atttctggcc aaagcaattg aacctccccc tttggatgct    420

gtgattgaag cagaacacac tcttagagag cttgatgcat tagatgccaa tgatgagttg    480

actcctttgg gacgaatcct ggctaaactc cccattgagc ctcgttttgg caaaatgatg    540

ataatggggt gtattttcta cgtgggagat gctatctgta ccattgctgc tgctacctgc    600

tttccagagc ctttcatcaa tgaaggaaag cggctgggct atatccatcg aaattttgct    660

ggaaacagat tttctgatca cgtagccctt ttatcagtat tccaagcctg ggatgatgct    720

agaatgggtg gagaagaagc agagatacgt ttttgtgagc acaaaagact taatatggct    780

acactaagaa tgacttggga agccaaagtt cagctcaaag agattttgat taattctggg    840

tttccagaag attgtttgtt gacacaagtg tttactaaca ctggaccaga taataatttg    900

gatgttgtta tctccctcct ggcctttgta gccaagacat gaagtaccca tctcccttct    960

ttgtatttgg tgaaaagatt cgaactcgag ccatctctgc taaaggcatg actttagtca   1020

cccccctgca gttgcttctc tttgcctcca agaaagtcca atctgatggg cagattgtgc   1080

ttgtagatga ctggattaaa ctgcaaatat ctcatgaagc tgctgcctgt atcactggtc   1140

tccgggcagc catggaggct ttggttgttg aagtaaccaa acaacctgct atcatcagcc   1200

agttggaccc cgtaaatgaa cgtatgctga acatgatccg tcagatctct agaccctcag   1260

ctgctggtat caaccttatg attggcagta cacggtatgg agatggtcca cgtcctccca   1320

agatggcccg atacgacaat ggaagcggat atagaagggg aggttctagt tacagtggtg   1380

gaggctatgg cggtggctat agcagtggag gctatggtag cggaggctat ggtggcagcg   1440

ccaactcctt tcgggcagga tatggtgcag gtgttggtgg aggctataga ggagtttccc   1500

gaggtggctt tagaggcaac tctggaggag actacagagg gcctagtgga ggctacagag   1560

gatctggggg attccagcga ggaggtggta ggggggccta tggaactggc tactttggac   1620

agggaagagg aggtggcggc tattaaaact tggttatgtc agttcctgtg tgtagacagt   1680

aaggaaaaaa aggcatgcta tgtgttacgt gttttttcca gtatgtttat ttgccaccaa   1740

aaagtaaatg cattttcacc cattctgtgg ttcattgtag tttaaggaaa ccaagcatat   1800

agatgcatta gtgattttgt ttatattatg taaaatataa cgatctctta aaaataccac   1860

agtttgtatt ttttctttaa ggagtaaaga tttgccttta aataacttgg tattttcctg   1920

gctttcgttt aatacaatag aaaataaagt attacaccga at                      1962


<210>  6802
<211>  257
<212>  PRT
<213>  Homosapiens

<400>  6802

Met Thr Asn Tyr Ala Thr Val Trp Ala Ser Lys Thr Asn Leu Glu Gln 
1               5                   10                  15      


Arg Lys Gly Arg Ala Gly Arg Val Arg Pro Gly Phe Cys Phe His Leu 
            20                  25                  30          


Cys Ser Arg Ala Arg Phe Glu Arg Leu Glu Thr His Met Thr Pro Glu 
        35                  40                  45              


Met Phe Arg Thr Pro Leu His Glu Ile Ala Leu Ser Ile Lys Leu Leu 
    50                  55                  60                  


Arg Leu Gly Gly Ile Gly Gln Phe Leu Ala Lys Ala Ile Glu Pro Pro 
65                  70                  75                  80  


Pro Leu Asp Ala Val Ile Glu Ala Glu His Thr Leu Arg Glu Leu Asp 
                85                  90                  95      


Ala Leu Asp Ala Asn Asp Glu Leu Thr Pro Leu Gly Arg Ile Leu Ala 
            100                 105                 110         


Lys Leu Pro Ile Glu Pro Arg Phe Gly Lys Met Met Ile Met Gly Cys 
        115                 120                 125             


Ile Phe Tyr Val Gly Asp Ala Ile Cys Thr Ile Ala Ala Ala Thr Cys 
    130                 135                 140                 


Phe Pro Glu Pro Phe Ile Asn Glu Gly Lys Arg Leu Gly Tyr Ile His 
145                 150                 155                 160 


Arg Asn Phe Ala Gly Asn Arg Phe Ser Asp His Val Ala Leu Leu Ser 
                165                 170                 175     


Val Phe Gln Ala Trp Asp Asp Ala Arg Met Gly Gly Glu Glu Ala Glu 
            180                 185                 190         


Ile Arg Phe Cys Glu His Lys Arg Leu Asn Met Ala Thr Leu Arg Met 
        195                 200                 205             


Thr Trp Glu Ala Lys Val Gln Leu Lys Glu Ile Leu Ile Asn Ser Gly 
    210                 215                 220                 


Phe Pro Glu Asp Cys Leu Leu Thr Gln Val Phe Thr Asn Thr Gly Pro 
225                 230                 235                 240 


Asp Asn Asn Leu Asp Val Val Ile Ser Leu Leu Ala Phe Val Ala Lys 
                245                 250                 255     


Thr 
    


<210>  6803
<211>  2194
<212>  DNA
<213>  Homosapiens

<400>  6803
gggaaaccta tttgtctgct ccagtgttac taactggaaa cttcttacca gttaacagaa     60

tcaaaaacac cttattttta aactcctgtg ttcttaaatc tccaaaatta ttgtgcatct    120

atatagcatt ataggcagaa agtgaaactc ttcactgctc acaacaatat gaccaactat    180

gctaccgtat gggcatcaaa aacaaacctt gagcaacgga aagggcgagc tggccgagta    240

cggcctggat tctgctttca cctgtgcagc cgagctcgtt ttgagagact tgaaacccac    300

atgacaccag agatgttccg aacaccattg catgaaattg ctcttagcat aaaacttctg    360

cgtctaggag gaattggcca atttctggcc aaagcaattg aacctccccc tttggatgct    420

gtgattgaag cagaacacac tcttagagag cttgatgcat tagatgccaa tgatgagttg    480

actcctttgg gacgaatcct ggctaaactc cccattgagc ctcgttttgg caaaatgatg    540

ataatggggt gtattttcta cgtgggagat gctatctgta ccattgctgc tgctacctgc    600

tttccagagc ctttcatcaa tgaaggaaag cggctgggct atatccatcg aaattttgct    660

ggaaacagat tttctgatca cgtagccctt ttatcagtat tccaagcctg ggatgatgct    720

agaatgggtg gagaagaagc agagatacgt ttttgtgagc acaaaagact taatatggct    780

acactaagaa tgacttggga agccaaagtt cagctcaaag agattttgat taattctggg    840

tttccagaag attgtttgtt gacacaagtg tttactaaca ctggaccaga taataatttg    900

gatgttgtta tctccctcct ggcctttgta gccaagacat gaagtaccca tctcccttct    960

ttgtatttgg tgaaaagatt cgaactcgag ccatctctgc taaaggcatg actttagtca   1020

cccccctgca gttgcttctc tttgcctcca agaaagtcca atctgatggg cagattgtgc   1080

ttgtagatga ctggattaaa ctgcaaatat ctcatgaagc tgctgcctgt atcactggtc   1140

tccgggcagc catggaggct ttggttgttg aagtaaccaa acaacctgct atcatcagcc   1200

agttggaccc cgtaaatgaa cgtatgctga acatgatccg tcagatctct agaccctcag   1260

ctgctggtat caaccttatg attggcagta cacggtatgg agatggtcca cgtcctccca   1320

agatggcccg atacgacaat ggaagcggat atagaagggg aggttctagt tacagtggtg   1380

gaggctatgg cggtggctat agcagtggag gctatggtag cggaggctat ggtggcagcg   1440

ccaactcctt tcgggcagga tatggtgcag gtgttggtgg aggctataga ggagtttccc   1500

gaggtggctt tagaggcaac tctggaggag actacagagg gcctagtgga ggctacagag   1560

gatctggggg attccagcga ggaggtggta ggggggccta tggaactggc tactttggac   1620

agggaagagg aggtggcggc tattaaaact tggttatgtc agttcctgtg tgtagacagt   1680

aaggaaaaaa aggcatgcta tgtgttacgt gttttttcca gtatgtttat ttgccaccaa   1740

aaagtaaatg cattttcacc cattctgtgg ttcattgtag tttaaggaaa ccaagcatat   1800

agatgcatta gtgattttgt ttatattatg taaaatataa cgatctctta aaaataccac   1860

agtttgtatt ttttctttaa ggagtaaaga tttgccttta aataacttgg tattttcctg   1920

gctttcgttt aatacaatag aaaataaagt attacaccga atacttgccg tgtagtttgt   1980

ttgttgacct cgtatgttag aaaattttac aatgccagct acatctgttg attttaaatg   2040

tcagagaagt tgtaccctgt ttcaaaagta tactaagtga tactacttgt aatagaataa   2100

atcatcttgg aattgaattg ttaccttttg aagtaaatac tggcaagtgc acaagccaca   2160

taaacctgaa taaaactttt gacctagggt tgaa                               2194


<210>  6804
<211>  257
<212>  PRT
<213>  Homosapiens

<400>  6804

Met Thr Asn Tyr Ala Thr Val Trp Ala Ser Lys Thr Asn Leu Glu Gln 
1               5                   10                  15      


Arg Lys Gly Arg Ala Gly Arg Val Arg Pro Gly Phe Cys Phe His Leu 
            20                  25                  30          


Cys Ser Arg Ala Arg Phe Glu Arg Leu Glu Thr His Met Thr Pro Glu 
        35                  40                  45              


Met Phe Arg Thr Pro Leu His Glu Ile Ala Leu Ser Ile Lys Leu Leu 
    50                  55                  60                  


Arg Leu Gly Gly Ile Gly Gln Phe Leu Ala Lys Ala Ile Glu Pro Pro 
65                  70                  75                  80  


Pro Leu Asp Ala Val Ile Glu Ala Glu His Thr Leu Arg Glu Leu Asp 
                85                  90                  95      


Ala Leu Asp Ala Asn Asp Glu Leu Thr Pro Leu Gly Arg Ile Leu Ala 
            100                 105                 110         


Lys Leu Pro Ile Glu Pro Arg Phe Gly Lys Met Met Ile Met Gly Cys 
        115                 120                 125             


Ile Phe Tyr Val Gly Asp Ala Ile Cys Thr Ile Ala Ala Ala Thr Cys 
    130                 135                 140                 


Phe Pro Glu Pro Phe Ile Asn Glu Gly Lys Arg Leu Gly Tyr Ile His 
145                 150                 155                 160 


Arg Asn Phe Ala Gly Asn Arg Phe Ser Asp His Val Ala Leu Leu Ser 
                165                 170                 175     


Val Phe Gln Ala Trp Asp Asp Ala Arg Met Gly Gly Glu Glu Ala Glu 
            180                 185                 190         


Ile Arg Phe Cys Glu His Lys Arg Leu Asn Met Ala Thr Leu Arg Met 
        195                 200                 205             


Thr Trp Glu Ala Lys Val Gln Leu Lys Glu Ile Leu Ile Asn Ser Gly 
    210                 215                 220                 


Phe Pro Glu Asp Cys Leu Leu Thr Gln Val Phe Thr Asn Thr Gly Pro 
225                 230                 235                 240 


Asp Asn Asn Leu Asp Val Val Ile Ser Leu Leu Ala Phe Val Ala Lys 
                245                 250                 255     


Thr 
    


<210>  6805
<211>  2534
<212>  DNA
<213>  Homosapiens

<400>  6805
tggccaactt gtaccccatg acttctcttt ataattcctt agtctgtcct gacaatgaaa     60

acaatttgct gccaacatcc attttaggaa atgatgaata gcattctgtg ccaatcccag    120

tcatttagtg gcagctgtct ctgtatgtaa cattgaagga atctgaggtt acttgggggt    180

tcaaatggac cacacaggca tcactagata cagatatcct aaaagttaca ctaaactttg    240

gaatagagat gacttaaata attactttct tttgtgtatg tgccatattc catttaaatg    300

ctttgcattt gttaatttat ttaatgttta ccaaaaaaac tataaggtag ataatggcat    360

gcaaagtttg gccaaggcag ttcagctgat aagtggcaag tggatgttac attgcctttt    420

agtaggttga caactaggag tttgcagtca gattgctgat tcttacttgt gccattcatg    480

aatagacatc acaagtaggt atggctttaa ctacatagtg gaaagcattc actacttagt    540

ggatatataa tagttattga taatacacat gagtcttaga attaaccact ttttcctatg    600

taggcagaaa gtgaaactct tcactgctca caacaatatg accaactatg ctaccgtatg    660

ggcatcaaaa acaaaccttg agcaacggaa agggcgagct ggccgagtac ggcctggatt    720

ctgctttcac ctgtgcagcc gagctcgttt tgagagactt gaaacccaca tgacaccaga    780

gatgttccga acaccattgc atgaaattgc tcttagcata aaacttctgc gtctaggagg    840

aattggccaa tttctggcca aagcaattga acctccccct ttggatgctg tgattgaagc    900

agaacacact cttagagagc ttgatgcatt agatgccaat gatgagttga ctcctttggg    960

acgaatcctg gctaaactcc ccattgagcc tcgttttggc aaaatgatga taatggggtg   1020

tattttctac gtgggagatg ctatctgtac cattgctgct gctacctgct ttccagagcc   1080

tttcatcaat gaaggaaagc ggctgggcta tatccatcga aattttgctg gaaacagatt   1140

ttctgatcac gtagcccttt tatcagtatt ccaagcctgg gatgatgcta gaatgggtgg   1200

agaagaagca gagatacgtt tttgtgagca caaaagactt aatatggcta cactaagaat   1260

gacttgggaa gccaaagttc agctcaaaga gattttgatt aattctgggt ttccagaaga   1320

ttgtttgttg acacaagtgt ttactaacac tggaccagat aataatttgg atgttgttat   1380

ctccctcctg gcctttggtg tgtaccccaa tgtatgctat cataaggaaa agaggaagat   1440

tctcaccact gaagggcgta atgcacttat ccacaaatca tctgttaatt gtccttttag   1500

tagccaagac atgaagtacc catctccctt ctttgtattt ggtgaaaaga ttcgaactcg   1560

agccatctct gctaaaggca tgactttagt cacccccctg cagttgcttc tctttgcctc   1620

caagaaagtc caatctgatg ggcagattgt gcttgtagat gactggatta aactgcaaat   1680

atctcatgaa gctgctgcct gtatcactgg tctccgggca gccatggagg ctttggttgt   1740

tgaagtaacc aaacaacctg ctatcatcag ccagttggac cccgtaaatg aacgtatgct   1800

gaacatgatc cgtcagatct ctagaccctc agctgctggt atcaacctta tgattggcag   1860

tacacggtat ggagatggtc cacgtcctcc caagatggcc cgatacgaca atggaagcgg   1920

atatagaagg ggaggttcta gttacagtgg tggaggctat ggcggtggct atagcagtgg   1980

aggctatggt agcggaggct atggtggcag cgccaactcc tttcgggcag gatatggtgc   2040

aggtgttggt ggaggctata gaggagtttc ccgaggtggc tttagaggca actctggagg   2100

agactacaga gggcctagtg gaggctacag aggatctggg ggattccagc gaggaggtgg   2160

taggggggcc tatggaactg gctactttgg acagggaaga ggaggtggcg gctattaaaa   2220

cttggttatg tcagttcctg tgtgtagaca gtaaggaaaa aaaggcatgc tatgtgttac   2280

gtgttttttc cagtatgttt atttgccacc aaaaagtaaa tgcattttca cccattctgt   2340

ggttcattgt agtttaagga aaccaagcat atagatgcat tagtgatttt gtttatatta   2400

tgtaaaatat aacgatctct taaaaatacc acagtttgta ttttttcttt aaggagtaaa   2460

gatttgcctt taaataactt ggtattttcc tggctttcgt ttaatacaat agaaaataaa   2520

gtattacacc gaat                                                     2534


<210>  6806
<211>  549
<212>  PRT
<213>  Homosapiens

<400>  6806

Met Ser Leu Arg Ile Asn His Phe Phe Leu Cys Arg Gln Lys Val Lys 
1               5                   10                  15      


Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr Val Trp Ala 
            20                  25                  30          


Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Val Arg 
        35                  40                  45              


Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg Leu 
    50                  55                  60                  


Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu Ile 
65                  70                  75                  80  


Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe Leu 
                85                  90                  95      


Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala Glu 
            100                 105                 110         


His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu Thr 
        115                 120                 125             


Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe Gly 
    130                 135                 140                 


Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile Cys 
145                 150                 155                 160 


Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu Gly 
                165                 170                 175     


Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe Ser 
            180                 185                 190         


Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala Arg 
        195                 200                 205             


Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg Leu 
    210                 215                 220                 


Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu Lys 
225                 230                 235                 240 


Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr Gln 
                245                 250                 255     


Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile Ser 
            260                 265                 270         


Leu Leu Ala Phe Gly Val Tyr Pro Asn Val Cys Tyr His Lys Glu Lys 
        275                 280                 285             


Arg Lys Ile Leu Thr Thr Glu Gly Arg Asn Ala Leu Ile His Lys Ser 
    290                 295                 300                 


Ser Val Asn Cys Pro Phe Ser Ser Gln Asp Met Lys Tyr Pro Ser Pro 
305                 310                 315                 320 


Phe Phe Val Phe Gly Glu Lys Ile Arg Thr Arg Ala Ile Ser Ala Lys 
                325                 330                 335     


Gly Met Thr Leu Val Thr Pro Leu Gln Leu Leu Leu Phe Ala Ser Lys 
            340                 345                 350         


Lys Val Gln Ser Asp Gly Gln Ile Val Leu Val Asp Asp Trp Ile Lys 
        355                 360                 365             


Leu Gln Ile Ser His Glu Ala Ala Ala Cys Ile Thr Gly Leu Arg Ala 
    370                 375                 380                 


Ala Met Glu Ala Leu Val Val Glu Val Thr Lys Gln Pro Ala Ile Ile 
385                 390                 395                 400 


Ser Gln Leu Asp Pro Val Asn Glu Arg Met Leu Asn Met Ile Arg Gln 
                405                 410                 415     


Ile Ser Arg Pro Ser Ala Ala Gly Ile Asn Leu Met Ile Gly Ser Thr 
            420                 425                 430         


Arg Tyr Gly Asp Gly Pro Arg Pro Pro Lys Met Ala Arg Tyr Asp Asn 
        435                 440                 445             


Gly Ser Gly Tyr Arg Arg Gly Gly Ser Ser Tyr Ser Gly Gly Gly Tyr 
    450                 455                 460                 


Gly Gly Gly Tyr Ser Ser Gly Gly Tyr Gly Ser Gly Gly Tyr Gly Gly 
465                 470                 475                 480 


Ser Ala Asn Ser Phe Arg Ala Gly Tyr Gly Ala Gly Val Gly Gly Gly 
                485                 490                 495     


Tyr Arg Gly Val Ser Arg Gly Gly Phe Arg Gly Asn Ser Gly Gly Asp 
            500                 505                 510         


Tyr Arg Gly Pro Ser Gly Gly Tyr Arg Gly Ser Gly Gly Phe Gln Arg 
        515                 520                 525             


Gly Gly Gly Arg Gly Ala Tyr Gly Thr Gly Tyr Phe Gly Gln Gly Arg 
    530                 535                 540                 


Gly Gly Gly Gly Tyr 
545                 


<210>  6807
<211>  2766
<212>  DNA
<213>  Homosapiens

<400>  6807
tggccaactt gtaccccatg acttctcttt ataattcctt agtctgtcct gacaatgaaa     60

acaatttgct gccaacatcc attttaggaa atgatgaata gcattctgtg ccaatcccag    120

tcatttagtg gcagctgtct ctgtatgtaa cattgaagga atctgaggtt acttgggggt    180

tcaaatggac cacacaggca tcactagata cagatatcct aaaagttaca ctaaactttg    240

gaatagagat gacttaaata attactttct tttgtgtatg tgccatattc catttaaatg    300

ctttgcattt gttaatttat ttaatgttta ccaaaaaaac tataaggtag ataatggcat    360

gcaaagtttg gccaaggcag ttcagctgat aagtggcaag tggatgttac attgcctttt    420

agtaggttga caactaggag tttgcagtca gattgctgat tcttacttgt gccattcatg    480

aatagacatc acaagtaggt atggctttaa ctacatagtg gaaagcattc actacttagt    540

ggatatataa tagttattga taatacacat gagtcttaga attaaccact ttttcctatg    600

taggcagaaa gtgaaactct tcactgctca caacaatatg accaactatg ctaccgtatg    660

ggcatcaaaa acaaaccttg agcaacggaa agggcgagct ggccgagtac ggcctggatt    720

ctgctttcac ctgtgcagcc gagctcgttt tgagagactt gaaacccaca tgacaccaga    780

gatgttccga acaccattgc atgaaattgc tcttagcata aaacttctgc gtctaggagg    840

aattggccaa tttctggcca aagcaattga acctccccct ttggatgctg tgattgaagc    900

agaacacact cttagagagc ttgatgcatt agatgccaat gatgagttga ctcctttggg    960

acgaatcctg gctaaactcc ccattgagcc tcgttttggc aaaatgatga taatggggtg   1020

tattttctac gtgggagatg ctatctgtac cattgctgct gctacctgct ttccagagcc   1080

tttcatcaat gaaggaaagc ggctgggcta tatccatcga aattttgctg gaaacagatt   1140

ttctgatcac gtagcccttt tatcagtatt ccaagcctgg gatgatgcta gaatgggtgg   1200

agaagaagca gagatacgtt tttgtgagca caaaagactt aatatggcta cactaagaat   1260

gacttgggaa gccaaagttc agctcaaaga gattttgatt aattctgggt ttccagaaga   1320

ttgtttgttg acacaagtgt ttactaacac tggaccagat aataatttgg atgttgttat   1380

ctccctcctg gcctttggtg tgtaccccaa tgtatgctat cataaggaaa agaggaagat   1440

tctcaccact gaagggcgta atgcacttat ccacaaatca tctgttaatt gtccttttag   1500

tagccaagac atgaagtacc catctccctt ctttgtattt ggtgaaaaga ttcgaactcg   1560

agccatctct gctaaaggca tgactttagt cacccccctg cagttgcttc tctttgcctc   1620

caagaaagtc caatctgatg ggcagattgt gcttgtagat gactggatta aactgcaaat   1680

atctcatgaa gctgctgcct gtatcactgg tctccgggca gccatggagg ctttggttgt   1740

tgaagtaacc aaacaacctg ctatcatcag ccagttggac cccgtaaatg aacgtatgct   1800

gaacatgatc cgtcagatct ctagaccctc agctgctggt atcaacctta tgattggcag   1860

tacacggtat ggagatggtc cacgtcctcc caagatggcc cgatacgaca atggaagcgg   1920

atatagaagg ggaggttcta gttacagtgg tggaggctat ggcggtggct atagcagtgg   1980

aggctatggt agcggaggct atggtggcag cgccaactcc tttcgggcag gatatggtgc   2040

aggtgttggt ggaggctata gaggagtttc ccgaggtggc tttagaggca actctggagg   2100

agactacaga gggcctagtg gaggctacag aggatctggg ggattccagc gaggaggtgg   2160

taggggggcc tatggaactg gctactttgg acagggaaga ggaggtggcg gctattaaaa   2220

cttggttatg tcagttcctg tgtgtagaca gtaaggaaaa aaaggcatgc tatgtgttac   2280

gtgttttttc cagtatgttt atttgccacc aaaaagtaaa tgcattttca cccattctgt   2340

ggttcattgt agtttaagga aaccaagcat atagatgcat tagtgatttt gtttatatta   2400

tgtaaaatat aacgatctct taaaaatacc acagtttgta ttttttcttt aaggagtaaa   2460

gatttgcctt taaataactt ggtattttcc tggctttcgt ttaatacaat agaaaataaa   2520

gtattacacc gaatacttgc cgtgtagttt gtttgttgac ctcgtatgtt agaaaatttt   2580

acaatgccag ctacatctgt tgattttaaa tgtcagagaa gttgtaccct gtttcaaaag   2640

tatactaagt gatactactt gtaatagaat aaatcatctt ggaattgaat tgttaccttt   2700

tgaagtaaat actggcaagt gcacaagcca cataaacctg aataaaactt ttgacctagg   2760

gttgaa                                                              2766


<210>  6808
<211>  549
<212>  PRT
<213>  Homosapiens

<400>  6808

Met Ser Leu Arg Ile Asn His Phe Phe Leu Cys Arg Gln Lys Val Lys 
1               5                   10                  15      


Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr Val Trp Ala 
            20                  25                  30          


Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Val Arg 
        35                  40                  45              


Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg Leu 
    50                  55                  60                  


Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu Ile 
65                  70                  75                  80  


Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe Leu 
                85                  90                  95      


Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala Glu 
            100                 105                 110         


His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu Thr 
        115                 120                 125             


Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe Gly 
    130                 135                 140                 


Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile Cys 
145                 150                 155                 160 


Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu Gly 
                165                 170                 175     


Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe Ser 
            180                 185                 190         


Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala Arg 
        195                 200                 205             


Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg Leu 
    210                 215                 220                 


Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu Lys 
225                 230                 235                 240 


Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr Gln 
                245                 250                 255     


Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile Ser 
            260                 265                 270         


Leu Leu Ala Phe Gly Val Tyr Pro Asn Val Cys Tyr His Lys Glu Lys 
        275                 280                 285             


Arg Lys Ile Leu Thr Thr Glu Gly Arg Asn Ala Leu Ile His Lys Ser 
    290                 295                 300                 


Ser Val Asn Cys Pro Phe Ser Ser Gln Asp Met Lys Tyr Pro Ser Pro 
305                 310                 315                 320 


Phe Phe Val Phe Gly Glu Lys Ile Arg Thr Arg Ala Ile Ser Ala Lys 
                325                 330                 335     


Gly Met Thr Leu Val Thr Pro Leu Gln Leu Leu Leu Phe Ala Ser Lys 
            340                 345                 350         


Lys Val Gln Ser Asp Gly Gln Ile Val Leu Val Asp Asp Trp Ile Lys 
        355                 360                 365             


Leu Gln Ile Ser His Glu Ala Ala Ala Cys Ile Thr Gly Leu Arg Ala 
    370                 375                 380                 


Ala Met Glu Ala Leu Val Val Glu Val Thr Lys Gln Pro Ala Ile Ile 
385                 390                 395                 400 


Ser Gln Leu Asp Pro Val Asn Glu Arg Met Leu Asn Met Ile Arg Gln 
                405                 410                 415     


Ile Ser Arg Pro Ser Ala Ala Gly Ile Asn Leu Met Ile Gly Ser Thr 
            420                 425                 430         


Arg Tyr Gly Asp Gly Pro Arg Pro Pro Lys Met Ala Arg Tyr Asp Asn 
        435                 440                 445             


Gly Ser Gly Tyr Arg Arg Gly Gly Ser Ser Tyr Ser Gly Gly Gly Tyr 
    450                 455                 460                 


Gly Gly Gly Tyr Ser Ser Gly Gly Tyr Gly Ser Gly Gly Tyr Gly Gly 
465                 470                 475                 480 


Ser Ala Asn Ser Phe Arg Ala Gly Tyr Gly Ala Gly Val Gly Gly Gly 
                485                 490                 495     


Tyr Arg Gly Val Ser Arg Gly Gly Phe Arg Gly Asn Ser Gly Gly Asp 
            500                 505                 510         


Tyr Arg Gly Pro Ser Gly Gly Tyr Arg Gly Ser Gly Gly Phe Gln Arg 
        515                 520                 525             


Gly Gly Gly Arg Gly Ala Tyr Gly Thr Gly Tyr Phe Gly Gln Gly Arg 
    530                 535                 540                 


Gly Gly Gly Gly Tyr 
545                 


<210>  6809
<211>  972
<212>  DNA
<213>  Homosapiens

<400>  6809
agacatgaag tacccatctc ccttctttgt atttggtgaa aagattcgaa ctcgagccat     60

ctctgctaaa ggcatgactt tagtcacccc cctgcagttg cttctctttg cctccaagaa    120

agtccaatct gatgggcaga ttgtgcttgt agatgactgg attaaactgc aaatatctca    180

tgaagctgct gcctgtatca ctggtctccg ggcagccatg gaggctttgg ttgttgaagt    240

aaccaaacaa cctgctatca tcagccagtt ggaccccgta aatgaacgta tgctgaacat    300

gatccgtcag atctctagac cctcagctgc tggtatcaac cttatgattg gcagtacacg    360

gtatggagat ggtccacgtc ctcccaagat ggcccgatac gacaatggaa gcggatatag    420

aaggggaggt tctagttaca gtggtggagg ctatggcggt ggctatagca gtggaggcta    480

tggtagcgga ggctatggtg gcagcgccaa ctcctttcgg gcaggatatg gtgcaggtgt    540

tggtggaggc tatagaggag tttcccgagg tggctttaga ggcaactctg gaggagacta    600

cagagggcct agtggaggct acagaggatc tgggggattc cagcgaggag gtggtagggg    660

ggcctatgga actggctact ttggacaggg aagaggaggt ggcggctatt aaaacttggt    720

tatgtcagtt cctgtgtgta gacagtaagg aaaaaaaggc atgctatgtg ttacgtgttt    780

tttccagtat gtttatttgc caccaaaaag taaatgcatt ttcacccatt ctgtggttca    840

ttgtagttta aggaaaccaa gcatatagat gcattagtga ttttgtttat attatgtaaa    900

atataacgat ctcttaaaaa taccacagtt tgtatttttt ctttaaggag taaagatttg    960

cctttaaata ac                                                        972


<210>  6810
<211>  235
<212>  PRT
<213>  Homosapiens

<400>  6810

Met Lys Tyr Pro Ser Pro Phe Phe Val Phe Gly Glu Lys Ile Arg Thr 
1               5                   10                  15      


Arg Ala Ile Ser Ala Lys Gly Met Thr Leu Val Thr Pro Leu Gln Leu 
            20                  25                  30          


Leu Leu Phe Ala Ser Lys Lys Val Gln Ser Asp Gly Gln Ile Val Leu 
        35                  40                  45              


Val Asp Asp Trp Ile Lys Leu Gln Ile Ser His Glu Ala Ala Ala Cys 
    50                  55                  60                  


Ile Thr Gly Leu Arg Ala Ala Met Glu Ala Leu Val Val Glu Val Thr 
65                  70                  75                  80  


Lys Gln Pro Ala Ile Ile Ser Gln Leu Asp Pro Val Asn Glu Arg Met 
                85                  90                  95      


Leu Asn Met Ile Arg Gln Ile Ser Arg Pro Ser Ala Ala Gly Ile Asn 
            100                 105                 110         


Leu Met Ile Gly Ser Thr Arg Tyr Gly Asp Gly Pro Arg Pro Pro Lys 
        115                 120                 125             


Met Ala Arg Tyr Asp Asn Gly Ser Gly Tyr Arg Arg Gly Gly Ser Ser 
    130                 135                 140                 


Tyr Ser Gly Gly Gly Tyr Gly Gly Gly Tyr Ser Ser Gly Gly Tyr Gly 
145                 150                 155                 160 


Ser Gly Gly Tyr Gly Gly Ser Ala Asn Ser Phe Arg Ala Gly Tyr Gly 
                165                 170                 175     


Ala Gly Val Gly Gly Gly Tyr Arg Gly Val Ser Arg Gly Gly Phe Arg 
            180                 185                 190         


Gly Asn Ser Gly Gly Asp Tyr Arg Gly Pro Ser Gly Gly Tyr Arg Gly 
        195                 200                 205             


Ser Gly Gly Phe Gln Arg Gly Gly Gly Arg Gly Ala Tyr Gly Thr Gly 
    210                 215                 220                 


Tyr Phe Gly Gln Gly Arg Gly Gly Gly Gly Tyr 
225                 230                 235 


<210>  6811
<211>  822
<212>  DNA
<213>  Homosapiens

<400>  6811
ggtatggaga tggtccacgt cctcccaaga tggcccgata cgacaatgga agcggatata     60

gaaggggagg ttctagttac agtggtggag gctatggcgg tggctatagc agtggaggct    120

atggtagcgg aggctatggt ggcagcgcca actcctttcg ggcaggatat ggtgcaggtg    180

ttggtggagg ctatagagga gtttcccgag gtggctttag aggcaactct ggaggagact    240

acagagggcc tagtggaggc tacagaggat ctgggggatt ccagcgagga ggtggtaggg    300

gggcctatgg aactggctac tttggacagg gaagaggagg tggcggctat taaaacttgg    360

ttatgtcagt tcctgtgtgt agacagtaag gaaaaaaagg catgctattt taaggaaacc    420

aagcatatag atgcattagt gattttgttt atattatgta aaatataacg atctcttaaa    480

aataccacag tttgtatttt ttctttaagg agtaaagatt tgcctttaaa taacttggta    540

ttttcctggc tttcgtttaa tacaatagaa aataaagtat tacaccgaat acttgccgtg    600

tagtttgttt gttgacctcg tatgttagaa aattttacaa tgccagctac atctgttgat    660

tttaaatgtc agagaagttg taccctgttt caaaagtata ctaagtgata ctacttgtaa    720

tagaataaat catcttggaa ttgaattgtt accttttgaa gtaaatactg gcaagtgcac    780

aagccacata aacctgaata aaacttttga cctagggttg aa                       822


<210>  6812
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  6812

Met Glu Met Val His Val Leu Pro Arg Trp Pro Asp Thr Thr Met Glu 
1               5                   10                  15      


Ala Asp Ile Glu Gly Glu Val Leu Val Thr Val Val Glu Ala Met Ala 
            20                  25                  30          


Val Ala Ile Ala Val Glu Ala Met Val Ala Glu Ala Met Val Ala Ala 
        35                  40                  45              


Pro Thr Pro Phe Gly Gln Asp Met Val Gln Val Leu Val Glu Ala Ile 
    50                  55                  60                  


Glu Glu Phe Pro Glu Val Ala Leu Glu Ala Thr Leu Glu Glu Thr Thr 
65                  70                  75                  80  


Glu Gly Leu Val Glu Ala Thr Glu Asp Leu Gly Asp Ser Ser Glu Glu 
                85                  90                  95      


Val Val Gly Gly Pro Met Glu Leu Ala Thr Leu Asp Arg Glu Glu Glu 
            100                 105                 110         


Val Ala Ala Ile Lys Thr Trp Leu Cys Gln Phe Leu Cys Val Asp Ser 
        115                 120                 125             


Lys Glu Lys Lys Ala Cys Tyr Phe Lys Glu Thr Lys His Ile Asp Ala 
    130                 135                 140                 


Leu Val Ile Leu Phe Ile Leu Cys Lys Ile 
145                 150                 


<210>  6813
<211>  2527
<212>  DNA
<213>  Homosapiens

<400>  6813
ggggttagag ccattgcgtt gggctcgtct ggcaccttct ggtgtgtgcg gcacctggtg     60

ggggttcggc acggagccgc acccaacact gacccgggcc cccccacccc tgtcctgagc    120

ccaggcgctt cgccctgtcc cacctagctc tgagcagcgc cccccagcac cctgaatgcg    180

tccgcaggac cccgcgctct acccgcaggc cccgcacccc ctagctctgg gccgcgcctc    240

acatccctcc cagagccgca acaccccacc cggcgggacg ccctcgagca gccgctcgtt    300

gcgggcctga agcgcagagc gcctattggc cagagcggcc gagggcggga aaagtggcca    360

acggctgcct cggccctcgg gctgctgagg agatggcgtc gggctccaag gcctcggtgc    420

ccgcggactc attccgcacc atcagcccgg acaggcgagg cgagaagtcc gcctccgctg    480

tctccgggga cacggcggcc gcgaccaccc tgaagggcac cgcgatccca gtgcggtcgg    540

tggtggcctc ccctcgcccg gtgaagggga aagcgggccg ggagacggcc aggctgcggc    600

tccagcgcct gcccgcggct caggccgagg acacgggaga ggcggcggcg gcggcggcgg    660

aggagcccct gctgccagtg cctgaggatg aagaggaggc gcagcccctg cccccagtct    720

gcgtgtcccg tatgaggggg atgtggcggg acgagaaggt gtcgctgtat tgcgacgaag    780

tgctgcagga ctgtaagtac agatggggtt tctccagttg gtcaggctgg actcgaactc    840

ccgacctcag gcagaagatg ctgatgaagt tatgggtaaa tacctatcag aaaaattaaa    900

gttgaaagac aaatggcttg gagtctggaa gactaatccc agtgtattct ttgtgaaata    960

tgaagaagct tctatccctt ttgttggtat attggttgag gtaacttgtg aaccatacca   1020

agactcatca tctcgtttca aagttactgt ttctgttgct gagccctttt cttccaacat   1080

tgcaaatatt ccaagagatt tggttgatga gattttggag gaactggaac acagtgtgcc   1140

tcttttggaa gtgtatcctg ttgagggaca agatactgat atacatgtta ttgctttggc   1200

cttggaagtt gtcaggtttt tttatgactt tctttggaga gactgggatg atgaagaaag   1260

ttgtgagaat tatactgcac ttattgaaga aagaattaat ttgtggtgtg atatacagga   1320

tggaacaata cctggtccta tcgcacaacg ttttaaaaaa actttggaga aatataaaaa   1380

caaacgtgtc gagctcattg agtatcagag caatattaaa gaagatccat ctgcagcaga   1440

ggctgttgaa tgctggaaaa aatactatga gatagtcatg ctctgtggat tactgaaaat   1500

gtgggaagat ttacgcctcc gagttcatgg acctttcttt ccaagaattc tgaggcgtag   1560

gaaaggaaaa agagaatttg gaaagactat aacacatatt gtagcaaaaa tgatgactac   1620

tgaaatgata aaggatttat cttcagacac acttctccaa cagcatggtg atttggattt   1680

ggctttggat aattgttata gtggagatac agtaataatt tttccaggag aatatcaagc   1740

tgcaaatctt gctttgttga cagatgacat cattataaag ggagttggaa agagagagga   1800

aattatgatt acttctgaac cttctcgtga cagttttgtg gtgtccaaag ctgacaatgt   1860

gaaactaatg catctatctt tgatacaaca agggacggtt gatggtatcg tggtggtgga   1920

gtctggtcac atgactctag aaaactgcat attaaaatgt gaaggaacag gagtgtgtgt   1980

tcttacaggg gctgctttga caattacaga cagtgaaata actggcgccc agggtgctgg   2040

tgttgaactg tatcctggaa gcatagctat tttggaaaga aatgaaattc atcactgtaa   2100

taacctcaga accagtaaca gttcaaaaag caccttaggt ggagttaata tgaaggttct   2160

tccagcaccc aaattgaaga tgactaataa tcatatttat agcaacaaag gctatggagt   2220

aagcattctt caaccaatgg aacagttttt tatcgtagca gaagaagctc tcaacaaaag   2280

ggcttcttca ggagataaaa aagatgataa aatgctcttc aaagtaatgc aaaatctgaa   2340

tctggaaatg aataataata agatagaagc aaacgtcaag ggggatatca gaatagtcac   2400

aagttaaagc gtctgaattg atgttaaagt tttatatttc acaaatttgt ttaatacatg   2460

attctcatac cccactgaaa tggtagtttc aattcaaagc ttaattaaaa aatatttaaa   2520

tatcatg                                                             2527


<210>  6814
<211>  534
<212>  PRT
<213>  Homosapiens

<400>  6814

Met Gly Phe Leu Gln Leu Val Arg Leu Asp Ser Asn Ser Arg Pro Gln 
1               5                   10                  15      


Ala Glu Asp Ala Asp Glu Val Met Gly Lys Tyr Leu Ser Glu Lys Leu 
            20                  25                  30          


Lys Leu Lys Asp Lys Trp Leu Gly Val Trp Lys Thr Asn Pro Ser Val 
        35                  40                  45              


Phe Phe Val Lys Tyr Glu Glu Ala Ser Ile Pro Phe Val Gly Ile Leu 
    50                  55                  60                  


Val Glu Val Thr Cys Glu Pro Tyr Gln Asp Ser Ser Ser Arg Phe Lys 
65                  70                  75                  80  


Val Thr Val Ser Val Ala Glu Pro Phe Ser Ser Asn Ile Ala Asn Ile 
                85                  90                  95      


Pro Arg Asp Leu Val Asp Glu Ile Leu Glu Glu Leu Glu His Ser Val 
            100                 105                 110         


Pro Leu Leu Glu Val Tyr Pro Val Glu Gly Gln Asp Thr Asp Ile His 
        115                 120                 125             


Val Ile Ala Leu Ala Leu Glu Val Val Arg Phe Phe Tyr Asp Phe Leu 
    130                 135                 140                 


Trp Arg Asp Trp Asp Asp Glu Glu Ser Cys Glu Asn Tyr Thr Ala Leu 
145                 150                 155                 160 


Ile Glu Glu Arg Ile Asn Leu Trp Cys Asp Ile Gln Asp Gly Thr Ile 
                165                 170                 175     


Pro Gly Pro Ile Ala Gln Arg Phe Lys Lys Thr Leu Glu Lys Tyr Lys 
            180                 185                 190         


Asn Lys Arg Val Glu Leu Ile Glu Tyr Gln Ser Asn Ile Lys Glu Asp 
        195                 200                 205             


Pro Ser Ala Ala Glu Ala Val Glu Cys Trp Lys Lys Tyr Tyr Glu Ile 
    210                 215                 220                 


Val Met Leu Cys Gly Leu Leu Lys Met Trp Glu Asp Leu Arg Leu Arg 
225                 230                 235                 240 


Val His Gly Pro Phe Phe Pro Arg Ile Leu Arg Arg Arg Lys Gly Lys 
                245                 250                 255     


Arg Glu Phe Gly Lys Thr Ile Thr His Ile Val Ala Lys Met Met Thr 
            260                 265                 270         


Thr Glu Met Ile Lys Asp Leu Ser Ser Asp Thr Leu Leu Gln Gln His 
        275                 280                 285             


Gly Asp Leu Asp Leu Ala Leu Asp Asn Cys Tyr Ser Gly Asp Thr Val 
    290                 295                 300                 


Ile Ile Phe Pro Gly Glu Tyr Gln Ala Ala Asn Leu Ala Leu Leu Thr 
305                 310                 315                 320 


Asp Asp Ile Ile Ile Lys Gly Val Gly Lys Arg Glu Glu Ile Met Ile 
                325                 330                 335     


Thr Ser Glu Pro Ser Arg Asp Ser Phe Val Val Ser Lys Ala Asp Asn 
            340                 345                 350         


Val Lys Leu Met His Leu Ser Leu Ile Gln Gln Gly Thr Val Asp Gly 
        355                 360                 365             


Ile Val Val Val Glu Ser Gly His Met Thr Leu Glu Asn Cys Ile Leu 
    370                 375                 380                 


Lys Cys Glu Gly Thr Gly Val Cys Val Leu Thr Gly Ala Ala Leu Thr 
385                 390                 395                 400 


Ile Thr Asp Ser Glu Ile Thr Gly Ala Gln Gly Ala Gly Val Glu Leu 
                405                 410                 415     


Tyr Pro Gly Ser Ile Ala Ile Leu Glu Arg Asn Glu Ile His His Cys 
            420                 425                 430         


Asn Asn Leu Arg Thr Ser Asn Ser Ser Lys Ser Thr Leu Gly Gly Val 
        435                 440                 445             


Asn Met Lys Val Leu Pro Ala Pro Lys Leu Lys Met Thr Asn Asn His 
    450                 455                 460                 


Ile Tyr Ser Asn Lys Gly Tyr Gly Val Ser Ile Leu Gln Pro Met Glu 
465                 470                 475                 480 


Gln Phe Phe Ile Val Ala Glu Glu Ala Leu Asn Lys Arg Ala Ser Ser 
                485                 490                 495     


Gly Asp Lys Lys Asp Asp Lys Met Leu Phe Lys Val Met Gln Asn Leu 
            500                 505                 510         


Asn Leu Glu Met Asn Asn Asn Lys Ile Glu Ala Asn Val Lys Gly Asp 
        515                 520                 525             


Ile Arg Ile Val Thr Ser 
    530                 


<210>  6815
<211>  2546
<212>  DNA
<213>  Homosapiens

<400>  6815
ggggttagag ccattgcgtt gggctcgtct ggcaccttct ggtgtgtgcg gcacctggtg     60

ggggttcggc acggagccgc acccaacact gacccgggcc cccccacccc tgtcctgagc    120

ccaggcgctt cgccctgtcc cacctagctc tgagcagcgc cccccagcac cctgaatgcg    180

tccgcaggac cccgcgctct acccgcaggc cccgcacccc ctagctctgg gccgcgcctc    240

acatccctcc cagagccgca acaccccacc cggcgggacg ccctcgagca gccgctcgtt    300

gcgggcctga agcgcagagc gcctattggc cagagcggcc gagggcggga aaagtggcca    360

acggctgcct cggccctcgg gctgctgagg agatggcgtc gggctccaag gcctcggtgc    420

ccgcggactc attccgcacc atcagcccgg acaggcgagg cgagaagtcc gcctccgctg    480

tctccgggga cacggcggcc gcgaccaccc tgaagggcac cgcgatccca gtgcggtcgg    540

tggtggcctc ccctcgcccg gtgaagggga aagcgggccg ggagacggcc aggctgcggc    600

tccagcgcct gcccgcggct caggccgagg acacgggaga ggcggcggcg gcggcggcgg    660

aggagcccct gctgccagtg cctgaggatg aagaggaggc gcagcccctg cccccagtct    720

gcgtgtcccg tatgaggggg atgtggcggg acgagaaggt gtcgctgtat tgcgacgaag    780

tgctgcagga ctgtaaggca gaagatgctg atgaagttat gggtaaatac ctatcagaaa    840

aattaaagtt gaaagacaaa tggcttggag tctggaagac taatcccagt gtattctttg    900

tgaaatatga agaagcttct atcccttttg ttggtatatt ggttgaggta acttgtgaac    960

cataccaaga ctcatcatct cgtttcaaag ttactgtttc tgttgctgag cccttttctt   1020

ccaacattgc aaatattcca agagatttgg ttgatgagat tttggaggaa ctggaacaca   1080

gtgtgcctct tttggaagtg tatcctgttg agggacaaga tactgatata catgttattg   1140

ctttggcctt ggaagttgtc aggttttttt atgactttct ttggagagac tgggatgatg   1200

aagaaagttg tgagaattat actgcactta ttgaagaaag aattaatttg taagtatagt   1260

ttataaactt ataccgcaca ttagaaaaaa taaacattgt aattatgttg ataattttca   1320

ggtggtgtga tatacaggat ggaacaatac ctggtcctat cgcacaacgt tttaaaaaaa   1380

ctttggagaa atataaaaac aaacgtgtcg agctcattga gtatcagagc aatattaaag   1440

aagatccatc tgcagcagag gctgttgaat gctggaaaaa atactatgag atagtcatgc   1500

tctgtggatt actgaaaatg tgggaagatt tacgcctccg agttcatgga cctttctttc   1560

caagaattct gaggcgtagg aaaggaaaaa gagaatttgg aaagactata acacatattg   1620

tagcaaaaat gatgactact gaaatgataa aggatttatc ttcagacaca cttctccaac   1680

agcatggtga tttggatttg gctttggata attgttatag tggagataca gtaataattt   1740

ttccaggaga atatcaagct gcaaatcttg ctttgttgac agatgacatc attataaagg   1800

gagttggaaa gagagaggaa attatgatta cttctgaacc ttctcgtgac agttttgtgg   1860

tgtccaaagc tgacaatgtg aaactaatgc atctatcttt gatacaacaa gggacggttg   1920

atggtatcgt ggtggtggag tctggtcaca tgactctaga aaactgcata ttaaaatgtg   1980

aaggaacagg agtgtgtgtt cttacagggg ctgctttgac aattacagac agtgaaataa   2040

ctggcgccca gggtgctggt gttgaactgt atcctggaag catagctatt ttggaaagaa   2100

atgaaattca tcactgtaat aacctcagaa ccagtaacag ttcaaaaagc accttaggtg   2160

gagttaatat gaaggttctt ccagcaccca aattgaagat gactaataat catatttata   2220

gcaacaaagg ctatggagta agcattcttc aaccaatgga acagtttttt atcgtagcag   2280

aagaagctct caacaaaagg gcttcttcag gagataaaaa agatgataaa atgctcttca   2340

aagtaatgca aaatctgaat ctggaaatga ataataataa gatagaagca aacgtcaagg   2400

gggatatcag aatagtcaca agttaaagcg tctgaattga tgttaaagtt ttatatttca   2460

caaatttgtt taatacatga ttctcatacc ccactgaaat ggtagtttca attcaaagct   2520

taattaaaaa atatttaaat atcatg                                        2546


<210>  6816
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  6816

Met Leu Ile Ile Phe Arg Trp Cys Asp Ile Gln Asp Gly Thr Ile Pro 
1               5                   10                  15      


Gly Pro Ile Ala Gln Arg Phe Lys Lys Thr Leu Glu Lys Tyr Lys Asn 
            20                  25                  30          


Lys Arg Val Glu Leu Ile Glu Tyr Gln Ser Asn Ile Lys Glu Asp Pro 
        35                  40                  45              


Ser Ala Ala Glu Ala Val Glu Cys Trp Lys Lys Tyr Tyr Glu Ile Val 
    50                  55                  60                  


Met Leu Cys Gly Leu Leu Lys Met Trp Glu Asp Leu Arg Leu Arg Val 
65                  70                  75                  80  


His Gly Pro Phe Phe Pro Arg Ile Leu Arg Arg Arg Lys Gly Lys Arg 
                85                  90                  95      


Glu Phe Gly Lys Thr Ile Thr His Ile Val Ala Lys Met Met Thr Thr 
            100                 105                 110         


Glu Met Ile Lys Asp Leu Ser Ser Asp Thr Leu Leu Gln Gln His Gly 
        115                 120                 125             


Asp Leu Asp Leu Ala Leu Asp Asn Cys Tyr Ser Gly Asp Thr Val Ile 
    130                 135                 140                 


Ile Phe Pro Gly Glu Tyr Gln Ala Ala Asn Leu Ala Leu Leu Thr Asp 
145                 150                 155                 160 


Asp Ile Ile Ile Lys Gly Val Gly Lys Arg Glu Glu Ile Met Ile Thr 
                165                 170                 175     


Ser Glu Pro Ser Arg Asp Ser Phe Val Val Ser Lys Ala Asp Asn Val 
            180                 185                 190         


Lys Leu Met His Leu Ser Leu Ile Gln Gln Gly Thr Val Asp Gly Ile 
        195                 200                 205             


Val Val Val Glu Ser Gly His Met Thr Leu Glu Asn Cys Ile Leu Lys 
    210                 215                 220                 


Cys Glu Gly Thr Gly Val Cys Val Leu Thr Gly Ala Ala Leu Thr Ile 
225                 230                 235                 240 


Thr Asp Ser Glu Ile Thr Gly Ala Gln Gly Ala Gly Val Glu Leu Tyr 
                245                 250                 255     


Pro Gly Ser Ile Ala Ile Leu Glu Arg Asn Glu Ile His His Cys Asn 
            260                 265                 270         


Asn Leu Arg Thr Ser Asn Ser Ser Lys Ser Thr Leu Gly Gly Val Asn 
        275                 280                 285             


Met Lys Val Leu Pro Ala Pro Lys Leu Lys Met Thr Asn Asn His Ile 
    290                 295                 300                 


Tyr Ser Asn Lys Gly Tyr Gly Val Ser Ile Leu Gln Pro Met Glu Gln 
305                 310                 315                 320 


Phe Phe Ile Val Ala Glu Glu Ala Leu Asn Lys Arg Ala Ser Ser Gly 
                325                 330                 335     


Asp Lys Lys Asp Asp Lys Met Leu Phe Lys Val Met Gln Asn Leu Asn 
            340                 345                 350         


Leu Glu Met Asn Asn Asn Lys Ile Glu Ala Asn Val Lys Gly Asp Ile 
        355                 360                 365             


Arg Ile Val Thr Ser 
    370             


<210>  6817
<211>  2474
<212>  DNA
<213>  Homosapiens

<400>  6817
ggggttagag ccattgcgtt gggctcgtct ggcaccttct ggtgtgtgcg gcacctggtg     60

ggggttcggc acggagccgc acccaacact gacccgggcc cccccacccc tgtcctgagc    120

ccaggcgctt cgccctgtcc cacctagctc tgagcagcgc cccccagcac cctgaatgcg    180

tccgcaggac cccgcgctct acccgcaggc cccgcacccc ctagctctgg gccgcgcctc    240

acatccctcc cagagccgca acaccccacc cggcgggacg ccctcgagca gccgctcgtt    300

gcgggcctga agcgcagagc gcctattggc cagagcggcc gagggcggga aaagtggcca    360

acggctgcct cggccctcgg gctgctgagg agatggcgtc gggctccaag gcctcggtgc    420

ccgcggactc attccgcacc atcagcccgg acaggcgagg cgagaagtcc gcctccgctg    480

tctccgggga cacggcggcc gcgaccaccc tgaagggcac cgcgatccca gtgcggtcgg    540

tggtggcctc ccctcgcccg gtgaagggga aagcgggccg ggagacggcc aggctgcggc    600

tccagcgcct gcccgcggct caggccgagg acacgggaga ggcggcggcg gcggcggcgg    660

aggagcccct gctgccagtg cctgaggatg aagaggaggc gcagcccctg cccccagtct    720

gcgtgtcccg tatgaggggg atgtggcggg acgagaaggt gtcgctgtat tgcgacgaag    780

tgctgcagga ctgtaaggca gaagatgctg atgaagttat gggtaaatac ctatcagaaa    840

aattaaagtt gaaagacaaa tggcttggag tctggaagac taatcccagt gtattctttg    900

tgaaatatga agaagcttct atcccttttg ttggtatatt ggttgaggta acttgtgaac    960

cataccaaga ctcatcatct cgtttcaaag ttactgtttc tgttgctgag cccttttctt   1020

ccaacattgc aaatattcca agagatttgg ttgatgagat tttggaggaa ctggaacaca   1080

gtgtgcctct tttggaagtg tatcctgttg agggacaaga tactgatata catgttattg   1140

ctttggcctt ggaagttgtc aggttttttt atgactttct ttggagagac tgggatgatg   1200

aagaaagttg tgagaattat actgcactta ttgaagaaag aattaatttg tggtgtgata   1260

tacaggatgg aacaatacct ggtcctatcg cacaacgttt taaaaaaact ttggagaaat   1320

ataaaaacaa acgtgtcgag ctcattgagt atcagagcaa tattaaagaa gatccatctg   1380

cagcagaggc tgttgaatgc tggaaaaaat actatgagat agtcatgctc tgtggattac   1440

tgaaaatgtg ggaagattta cgcctccgag ttcatggacc tttctttcca agaattctga   1500

ggcgtaggaa aggaaaaaga gaatttggaa agactataac acatattgta gcaaaaatga   1560

tgactactga aatgataaag gatttatctt cagacacact tctccaacag catggtgatt   1620

tggatttggc tttggataat tgttatagtg gagatacagt aataattttt ccaggagaat   1680

atcaagctgc aaatcttgct ttgttgacag atgacatcat tataaaggga gttggaaaga   1740

gagaggaaat tatgattact tctgaacctt ctcgtgacag ttttgtggtg tccaaagctg   1800

acaatgtgaa actaatgcat ctatctttga tacaacaagg gacggttgat ggtatcgtgg   1860

tggtggagtc tggtcacatg actctagaaa actgcatatt aaaatgtgaa ggaacaggag   1920

tgtgtgttct tacaggggct gctttgacaa ttacagacag tgaaataact ggcgcccagg   1980

gtgctggtgt tgaactgtat cctggaagca tagctatttt ggaaagaaat gaaattcatc   2040

actgtaataa cctcagaacc agtaacagtt caaaaagcac cttaggtgga gttaatatga   2100

aggttcttcc agcacccaaa ttgaagatga ctaataatca tatttatagc aacaaaggct   2160

atggagtaag cattcttcaa ccaatggaac agttttttat cgtagcagaa gaagctctca   2220

acaaaagggc ttcttcagga gataaaaaag atgataaaat gctcttcaaa gtaatgcaaa   2280

atctgaatct ggaaatgaat aataataaga tagaagcaaa cgtcaagggg gatatcagaa   2340

tagtcacaag ttaaagcgtc tgaattgatg ttaaagtttt atatttcaca aatttgttta   2400

atacatgatt ctcatacccc actgaaatgg tagtttcaat tcaaagctta attaaaaaat   2460

atttaaatat catg                                                     2474


<210>  6818
<211>  653
<212>  PRT
<213>  Homosapiens

<400>  6818

Met Ala Ser Gly Ser Lys Ala Ser Val Pro Ala Asp Ser Phe Arg Thr 
1               5                   10                  15      


Ile Ser Pro Asp Arg Arg Gly Glu Lys Ser Ala Ser Ala Val Ser Gly 
            20                  25                  30          


Asp Thr Ala Ala Ala Thr Thr Leu Lys Gly Thr Ala Ile Pro Val Arg 
        35                  40                  45              


Ser Val Val Ala Ser Pro Arg Pro Val Lys Gly Lys Ala Gly Arg Glu 
    50                  55                  60                  


Thr Ala Arg Leu Arg Leu Gln Arg Leu Pro Ala Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Thr Gly Glu Ala Ala Ala Ala Ala Ala Glu Glu Pro Leu Leu Pro Val 
                85                  90                  95      


Pro Glu Asp Glu Glu Glu Ala Gln Pro Leu Pro Pro Val Cys Val Ser 
            100                 105                 110         


Arg Met Arg Gly Met Trp Arg Asp Glu Lys Val Ser Leu Tyr Cys Asp 
        115                 120                 125             


Glu Val Leu Gln Asp Cys Lys Ala Glu Asp Ala Asp Glu Val Met Gly 
    130                 135                 140                 


Lys Tyr Leu Ser Glu Lys Leu Lys Leu Lys Asp Lys Trp Leu Gly Val 
145                 150                 155                 160 


Trp Lys Thr Asn Pro Ser Val Phe Phe Val Lys Tyr Glu Glu Ala Ser 
                165                 170                 175     


Ile Pro Phe Val Gly Ile Leu Val Glu Val Thr Cys Glu Pro Tyr Gln 
            180                 185                 190         


Asp Ser Ser Ser Arg Phe Lys Val Thr Val Ser Val Ala Glu Pro Phe 
        195                 200                 205             


Ser Ser Asn Ile Ala Asn Ile Pro Arg Asp Leu Val Asp Glu Ile Leu 
    210                 215                 220                 


Glu Glu Leu Glu His Ser Val Pro Leu Leu Glu Val Tyr Pro Val Glu 
225                 230                 235                 240 


Gly Gln Asp Thr Asp Ile His Val Ile Ala Leu Ala Leu Glu Val Val 
                245                 250                 255     


Arg Phe Phe Tyr Asp Phe Leu Trp Arg Asp Trp Asp Asp Glu Glu Ser 
            260                 265                 270         


Cys Glu Asn Tyr Thr Ala Leu Ile Glu Glu Arg Ile Asn Leu Trp Cys 
        275                 280                 285             


Asp Ile Gln Asp Gly Thr Ile Pro Gly Pro Ile Ala Gln Arg Phe Lys 
    290                 295                 300                 


Lys Thr Leu Glu Lys Tyr Lys Asn Lys Arg Val Glu Leu Ile Glu Tyr 
305                 310                 315                 320 


Gln Ser Asn Ile Lys Glu Asp Pro Ser Ala Ala Glu Ala Val Glu Cys 
                325                 330                 335     


Trp Lys Lys Tyr Tyr Glu Ile Val Met Leu Cys Gly Leu Leu Lys Met 
            340                 345                 350         


Trp Glu Asp Leu Arg Leu Arg Val His Gly Pro Phe Phe Pro Arg Ile 
        355                 360                 365             


Leu Arg Arg Arg Lys Gly Lys Arg Glu Phe Gly Lys Thr Ile Thr His 
    370                 375                 380                 


Ile Val Ala Lys Met Met Thr Thr Glu Met Ile Lys Asp Leu Ser Ser 
385                 390                 395                 400 


Asp Thr Leu Leu Gln Gln His Gly Asp Leu Asp Leu Ala Leu Asp Asn 
                405                 410                 415     


Cys Tyr Ser Gly Asp Thr Val Ile Ile Phe Pro Gly Glu Tyr Gln Ala 
            420                 425                 430         


Ala Asn Leu Ala Leu Leu Thr Asp Asp Ile Ile Ile Lys Gly Val Gly 
        435                 440                 445             


Lys Arg Glu Glu Ile Met Ile Thr Ser Glu Pro Ser Arg Asp Ser Phe 
    450                 455                 460                 


Val Val Ser Lys Ala Asp Asn Val Lys Leu Met His Leu Ser Leu Ile 
465                 470                 475                 480 


Gln Gln Gly Thr Val Asp Gly Ile Val Val Val Glu Ser Gly His Met 
                485                 490                 495     


Thr Leu Glu Asn Cys Ile Leu Lys Cys Glu Gly Thr Gly Val Cys Val 
            500                 505                 510         


Leu Thr Gly Ala Ala Leu Thr Ile Thr Asp Ser Glu Ile Thr Gly Ala 
        515                 520                 525             


Gln Gly Ala Gly Val Glu Leu Tyr Pro Gly Ser Ile Ala Ile Leu Glu 
    530                 535                 540                 


Arg Asn Glu Ile His His Cys Asn Asn Leu Arg Thr Ser Asn Ser Ser 
545                 550                 555                 560 


Lys Ser Thr Leu Gly Gly Val Asn Met Lys Val Leu Pro Ala Pro Lys 
                565                 570                 575     


Leu Lys Met Thr Asn Asn His Ile Tyr Ser Asn Lys Gly Tyr Gly Val 
            580                 585                 590         


Ser Ile Leu Gln Pro Met Glu Gln Phe Phe Ile Val Ala Glu Glu Ala 
        595                 600                 605             


Leu Asn Lys Arg Ala Ser Ser Gly Asp Lys Lys Asp Asp Lys Met Leu 
    610                 615                 620                 


Phe Lys Val Met Gln Asn Leu Asn Leu Glu Met Asn Asn Asn Lys Ile 
625                 630                 635                 640 


Glu Ala Asn Val Lys Gly Asp Ile Arg Ile Val Thr Ser 
                645                 650             


<210>  6819
<211>  1309
<212>  DNA
<213>  Homosapiens

<400>  6819
agcgcccccc agcaccctga atgcgtccgc aggaccccgc gctctacccg caggccccgc     60

accccctagc tctgggccgc gcctcacatc cctcccagag ccgcaacacc ccacccggcg    120

ggacgccctc gagcagccgc tcgttgcggg cctgaagcgc agagcgccta ttggccagag    180

cggccgaggg cgggaaaagt ggccaacggc tgcctcggcc ctcgggctgc tgaggagatg    240

gcgtcgggct ccaaggcctc ggtgcccgcg gactcattcc gcaccatcag cccggacagg    300

cgaggcgaga agtccgcctc cgctgtctcc ggggacacgg cggccgcgac caccctgaag    360

ggcaccgcga tcccagtgcg gtcggtggtg gcctcccctc gcccggtgaa ggggaaagcg    420

ggccgggaga cggccaggct gcggctccag cgcctgcccg cggctcaggc cgaggacacg    480

ggagaggcgg cggcggcggc ggcggaggag cccctgctgc cagtgcctga ggatgaagag    540

gaggcgcagc ccctgccccc agtctgcgtg tcccgtatga gggggatgtg gcgggacgag    600

aaggtgtcgc tgtattgcga cgaagtgctg caggactgta aggtgagcgg atccgggaca    660

ggaagactac ggtcggaagc tcgtcggaac ctggggacag gcatctgggg cttccctctt    720

aggcggatgg ggatccacag ggcacaacga aaacttgcgt ttcaaaaaag taaatggagt    780

caacatgtat agagcgttca ccttgttaga ggtgcccgcg tcctgcccta gaggagttaa    840

ggttcgagtt tccgacaaaa ttcgtcaggc agaagatgct gatgaagtta tgggtaaata    900

cctatcagaa aaattaaagt tgaaagacaa atggcttgga gtctggaaga ctaatcccag    960

tgtattcttt gtgaaatatg aagaagcttc tatccctttt gttggtatat tggttgaggt   1020

aacttgtgaa ccataccaag actcatcatc tcgtttcaaa gttactgttt ctgttgctga   1080

gcccttttct tccaacattg caaatattcc aagagatttg gttgatgaga ttttggagga   1140

actggaacac agtgtgcctc ttttggaagt gtatcctgtt gagggacaag atactgatat   1200

acatgttatt gctttggcct tggaagttgt caggtttttt tatgactttc tttggagaga   1260

ctgggatgat gaagaaagtt gtgagaatta tactgcactt attgaagaa               1309


<210>  6820
<211>  174
<212>  PRT
<213>  Homosapiens

<400>  6820

Met Tyr Arg Ala Phe Thr Leu Leu Glu Val Pro Ala Ser Cys Pro Arg 
1               5                   10                  15      


Gly Val Lys Val Arg Val Ser Asp Lys Ile Arg Gln Ala Glu Asp Ala 
            20                  25                  30          


Asp Glu Val Met Gly Lys Tyr Leu Ser Glu Lys Leu Lys Leu Lys Asp 
        35                  40                  45              


Lys Trp Leu Gly Val Trp Lys Thr Asn Pro Ser Val Phe Phe Val Lys 
    50                  55                  60                  


Tyr Glu Glu Ala Ser Ile Pro Phe Val Gly Ile Leu Val Glu Val Thr 
65                  70                  75                  80  


Cys Glu Pro Tyr Gln Asp Ser Ser Ser Arg Phe Lys Val Thr Val Ser 
                85                  90                  95      


Val Ala Glu Pro Phe Ser Ser Asn Ile Ala Asn Ile Pro Arg Asp Leu 
            100                 105                 110         


Val Asp Glu Ile Leu Glu Glu Leu Glu His Ser Val Pro Leu Leu Glu 
        115                 120                 125             


Val Tyr Pro Val Glu Gly Gln Asp Thr Asp Ile His Val Ile Ala Leu 
    130                 135                 140                 


Ala Leu Glu Val Val Arg Phe Phe Tyr Asp Phe Leu Trp Arg Asp Trp 
145                 150                 155                 160 


Asp Asp Glu Glu Ser Cys Glu Asn Tyr Thr Ala Leu Ile Glu 
                165                 170                 


<210>  6821
<211>  1231
<212>  DNA
<213>  Homosapiens

<400>  6821
ggggttagag ccattgcgtt gggctcgtct ggcaccttct ggtgtgtgcg gcacctggtg     60

ggggttcggc acggagccgc acccaacact gacccgggcc cccccacccc tgtcctgagc    120

ccaggcgctt cgccctgtcc cacctagctc tgagcagcgc cccccagcac cctgaatgcg    180

tccgcaggac cccgcgctct acccgcaggc cccgcacccc ctagctctgg gccgcgcctc    240

acatccctcc cagagccgca acaccccacc cggcgggacg ccctcgagca gccgctcgtt    300

gcgggcctga agcgcagagc gcctattggc cagagcggcc gagggcggga aaagtggcca    360

acggctgcct cggccctcgg gctgctgagg agatggcgtc gggctccaag gcctcggtgc    420

ccgcggactc attccgcacc atcagcccgg acaggcgagg cgagaagtcc gcctccgctg    480

tctccgggga cacggcggcc gcgaccaccc tgaagggcac cgcgatccca gtgcggtcgg    540

tggtggcctc ccctcgcccg gtgaagggga aagcgggccg ggagacggcc aggctgcggc    600

tccagcgcct gcccgcggct caggccgagg acacgggaga ggcggcggcg gcggcggcgg    660

aggagcccct gctgccagtg cctgaggatg aagaggaggc gcagcccctg cccccagtct    720

gcgtgtcccg tatgaggggg atgtggcggg acgagaaggt gtcgctgtat tgcgacgaag    780

tgctgcagga ctgtaagtac agatggggtt tctccagttg gtcaggctgg actcgaactc    840

ccgacctcag gcagaagatg ctgatgaagt tatgggtaaa tacctatcag aaaaattaaa    900

gttgaaagac aaatggcttg gagtctggaa gactaatccc agtgtattct ttgtgaaata    960

tgaagaagct tctatccctt ttgttggtat attggttgag agtttcgtcc tgtcgcccag   1020

gctggagtgc agtggtgtga tctcggctac tgcaacctct gcctccccgg ttcaagcgat   1080

tctcctgccc cagcctcccg agtagctggg attacaggcg catgccacca tgcccagcta   1140

attttttgta tctttggtag agacggggtt taaccctgtt ggccaggctg gtcttgaact   1200

cctaaccttg tgatctttag cagagaaggg g                                  1231


<210>  6822
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  6822

Met Ala Ser Gly Ser Lys Ala Ser Val Pro Ala Asp Ser Phe Arg Thr 
1               5                   10                  15      


Ile Ser Pro Asp Arg Arg Gly Glu Lys Ser Ala Ser Ala Val Ser Gly 
            20                  25                  30          


Asp Thr Ala Ala Ala Thr Thr Leu Lys Gly Thr Ala Ile Pro Val Arg 
        35                  40                  45              


Ser Val Val Ala Ser Pro Arg Pro Val Lys Gly Lys Ala Gly Arg Glu 
    50                  55                  60                  


Thr Ala Arg Leu Arg Leu Gln Arg Leu Pro Ala Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Thr Gly Glu Ala Ala Ala Ala Ala Ala Glu Glu Pro Leu Leu Pro Val 
                85                  90                  95      


Pro Glu Asp Glu Glu Glu Ala Gln Pro Leu Pro Pro Val Cys Val Ser 
            100                 105                 110         


Arg Met Arg Gly Met Trp Arg Asp Glu Lys Val Ser Leu Tyr Cys Asp 
        115                 120                 125             


Glu Val Leu Gln Asp Cys Lys Tyr Arg Trp Gly Phe Ser Ser Trp Ser 
    130                 135                 140                 


Gly Trp Thr Arg Thr Pro Asp Leu Arg Gln Lys Met Leu Met Lys Leu 
145                 150                 155                 160 


Trp Val Asn Thr Tyr Gln Lys Asn 
                165             


<210>  6823
<211>  454
<212>  DNA
<213>  Homosapiens

<400>  6823
tctttgtgtt ctcaaccttc tgccgcaatc ccaagtggaa gctctgttgg ctcgccctct     60

agtcctcttc ctgctgagcc agtcttcaac taggaatcac accagagtca ccaggacaag    120

gaaagctagg cccatctgaa ggagattctg ggcagtgtgg tctcagaggg cacagtcttt    180

ctggagtccc gtctctggtt aaaaggtttg gaaggctcgc cacatgaagg aattactgct    240

ggatgagaga tgctggagct ttggactgac cagggactct ggccagacct aggctggccc    300

agggacttaa ggcccaaggg aacataaatg aacaagtgct gttcaaggga gccactcacc    360

catctttttc tgtggattcg ttcctgctgg gaacatacca aacacgaagg aaaggggaaa    420

ctatcttcat tttagataaa gaactgcacg actt                                454


<210>  6824
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  6824

Met Asn Lys Cys Cys Ser Arg Glu Pro Leu Thr His Leu Phe Leu Trp 
1               5                   10                  15      


Ile Arg Ser Cys Trp Glu His Thr Lys His Glu Gly Lys Gly Lys Leu 
            20                  25                  30          


Ser Ser Phe 
        35  


<210>  6825
<211>  7933
<212>  DNA
<213>  Homosapiens

<400>  6825
gcgcactcgg gcacgcgctc ggaagtcggg ggtcggcgcg gagtgcaggc tgctcccggg     60

gtaggtgagg gaagcgcgga ggcggcgcgc gggggcagtg gtcggcgagc agcgcggtcc    120

tcgctagggg cgcccacccg tcagtctctc cggcgcgagc cgccgccacc gcccgcgccg    180

gagtcaggcc cctgggcccc caggctcaag cagcgaagcg gcctccgggg gacgccgcta    240

ggcgagagga acgcgccggt gcccttgcct tcgccgtgac ccagcgtgcg ggcggcggga    300

tgagagggag ccatcgggcc gcgccggccc tgcggccccg ggggcggctc tggcccgtgc    360

tggccgtgct ggcggcggcc gccgcggcgg gctgtgccca ggcagccatg gacgagtgca    420

cggacgaggg cgggcggccg cagcgctgca tgcccgagtt cgtcaacgcc gccttcaacg    480

tgactgtggt ggccaccaac acgtgtggga ctccgcccga ggaatactgt gtgcagaccg    540

gggtgaccgg ggtcaccaag tcctgtcacc tgtgcgacgc cgggcagccc cacctgcagc    600

acggggcagc cttcctgacc gactacaaca accaggccga caccacctgg tggcaaagcc    660

agaccatgct ggccggggtg cagtacccca gctccatcaa cctcacgctg cacctgggaa    720

aagcttttga catcacctat gtgcgtctca agttccacac cagccgcccg gagagctttg    780

ccatttacaa gcgcacacgg gaagacgggc cctggattcc ttaccagtac tacagtggtt    840

cctgtgagaa cacctactcc aaggcaaacc gcggcttcat caggacagga ggggacgagc    900

agcaggcctt gtgtactgat gaattcagtg acatttctcc cctcactggg ggcaacgtgg    960

ccttttctac cctggaagga aggcccagcg cctataactt tgacaatagc cctgtgctgc   1020

aggaatgggt aactgccact gacatcagag taactcttaa tcgcctgaac acttttggag   1080

atgaagtgtt taacgatccc aaagttctca agtcctatta ttatgccatc tctgattttg   1140

ctgtaggtgg cagatgtaaa tgtaatggac acgcaagcga gtgtatgaag aacgaatttg   1200

ataagctggt gtgtaattgc aaacataaca catatggagt agactgtgaa aagtgtcttc   1260

ctttcttcaa tgaccggccg tggaggaggg caactgcgga aagtgccagt gaatgcctgc   1320

cctgtgattg caatggtcga tcccaggaat gctacttcga ccctgaactc tatcgttcca   1380

ctggccatgg gggccactgt accaactgcc aggataacac agatggcgcc cactgtgaga   1440

ggtgccgaga gaacttcttc cgccttggca acaatgaagc ctgctcttca tgccactgta   1500

gtcctgtggg ctctctaagc acacagtgtg atagttacgg cagatgcagc tgtaagccag   1560

gagtgatggg ggacaaatgt gaccgttgcc agcctggatt ccattctctc actgaagcag   1620

gatgcaggcc atgctcttgt gatccctctg gcagcataga tgaatgtaat attgaaacag   1680

gaagatgtgt ttgcaaagac aatgtcgaag gcttcaattg tgaaagatgc aaacctggat   1740

tttttaatct ggaatcatct aatcctcggg gttgcacacc ctgcttctgc tttgggcatt   1800

cttctgtctg tacaaacgct gttggctaca gtgtttattc tatctcctct acctttcaga   1860

ttgatgagga tgggtggcgt gcggaacaga gagatggctc tgaagcatct ctcgagtggt   1920

cctctgagag gcaagatatc gccgtgatct cagacagcta ctttcctcgg tacttcattg   1980

ctcctgcaaa gttcttgggc aagcaggtgt tgagttatgg tcagaacctc tccttctcct   2040

ttcgagtgga caggcgagat actcgcctct ctgcagaaga ccttgtgctt gagggagctg   2100

gcttaagagt atctgtaccc ttgatcgctc agggcaattc ctatccaagt gagaccactg   2160

tgaagtatgt cttcaggctc catgaagcaa cagattaccc ttggaggcct gctcttaccc   2220

cttttgaatt tcagaagctc ctaaacaact tgacctctat caagatacgt gggacataca   2280

gtgagagaag tgctggatat ttggatgatg tcaccctggc aagtgctcgt cctgggcctg   2340

gagtccctgc aacttgggtg gagtcctgca cctgtcctgt gggatatgga gggcagtttt   2400

gtgagatgtg cctctcaggt tacagaagag aaactcctaa tcttggacca tacagtccat   2460

gtgtgctttg cgcctgcaat ggacacagcg agacctgtga tcctgagaca ggtgtttgta   2520

actgcagaga caatacggct ggcccgcact gtgagaagtg cagtgatggg tactatggag   2580

attcaactgc aggcacctcc tccgattgcc aaccctgtcc gtgtcctgga ggttcaagtt   2640

gtgctgttgt tcccaagaca aaggaggtgg tgtgcaccaa ctgtcctact ggcaccactg   2700

gtaagagatg tgagctctgt gatgatggct actttggaga ccccctgggt agaaacggcc   2760

ctgtgagact ttgccgcctg tgccagtgca gtgacaacat cgatcccaat gcagttggaa   2820

attgcaatcg cttgacggga gaatgcctga agtgcatcta taacactgct ggcttctatt   2880

gtgaccggtg caaagacgga ttttttggaa atcccctggc tcccaatcca gcagacaaat   2940

gcaaagcctg caattgcaat ctgtatggga ccatgaagca gcagagcagc tgtaaccccg   3000

tgacggggca gtgtgaatgt ttgcctcacg tgactggcca ggactgtggt gcttgtgacc   3060

ctggattcta caatctgcag agtgggcaag gctgtgagag gtgtgactgc catgccttgg   3120

gctccaccaa tgggcagtgt gacatccgca ccggccagtg tgagtgccag cccggcatca   3180

ctggtcagca ctgtgagcgc tgtgaggtca accactttgg gtttggacct gaaggctgca   3240

aaccctgtga ctgtcatcct gagggatctc tttcacttca gtgcaaagat gatggtcgct   3300

gtgaatgcag agaaggcttt gtgggaaatc gctgtgacca gtgtgaagaa aactatttct   3360

acaatcggtc ttggcctggc tgccaggaat gtccagcttg ttaccggctg gtaaaggata   3420

aggttgctga tcatagagtg aagctccagg aattagagag tctcatagca aaccttggaa   3480

ctggggatga gatggtgaca gatcaagcct tcgaggatag actaaaggaa gcagagaggg   3540

aagttatgga cctccttcgt gaggcccagg atgtcaaaga tgttgaccag aatttgatgg   3600

atcgcctaca gagagtgaat aacactctgt ccagccaaat tagccgttta cagaatatcc   3660

ggaataccat tgaagagact ggaaacttgg ctgaacaagc gcgtgcccat gtagagaaca   3720

cagagcggtt gattgaaatc gcatccagag aacttgagaa agcaaaagtc gctgctgcca   3780

atgtgtcagt cactcagcca gaatctacag gggacccaaa caacatgact cttttggcag   3840

aagaggctcg aaagcttgct gaacgtcata aacaggaagc tgatgacatt gttcgagtgg   3900

caaagacagc caatgatacg tcaactgagg catacaacct gcttctgagg acactggcag   3960

gagaaaatca aacagcattt gagattgaag agcttaatag gaagtatgaa caagcgaaga   4020

acatctcaca ggatctggaa aaacaagctg cccgagtaca tgaggaggcc aaaagggccg   4080

gtgacaaagc tgtggagatc tatgccagcg tggctcagct gagccctttg gactctgaga   4140

cactggagaa tgaagcaaat aacataaaga tggaagctga gaatctggaa caactgattg   4200

accagaaatt aaaagattat gaggacctca gagaagatat gagagggaag gaacttgaag   4260

tcaagaacct tctggagaaa ggcaagactg aacagcagac cgcagaccaa ctcctagccc   4320

gagctgatgc tgccaaggcc ctcgctgaag aagctgcaaa gaagggacgg gataccttac   4380

aagaagctaa tgacattctc aacaacctga aagattttga taggcgtgtg aacgataaca   4440

agacggccgc agaggaggca ctaaggaaga ttcctgccat caaccagacc atcactgaag   4500

ccaatgaaaa gaccagagaa gcccagcagg ccctgggcag tgctgcggcg gatgccacag   4560

aggccaagaa caaggcccat gaggcggaga ggatcgcgag cgctgtccaa aagaatgcca   4620

ccagcaccaa ggcagaagct gaaagaactt ttgcagaagt tacagatctg gataatgagg   4680

tgaacaatat gttgaagcaa ctgcaggaag cagaaaaaga gctaaagaga aaacaagatg   4740

acgctgacca ggacatgatg atggcaggga tggcttcaca ggctgctcaa gaagccgaga   4800

tcaatgccag aaaagccaaa aactctgtta ctagcctcct cagcattatt aatgacctct   4860

tggagcagct ggggcagctg gatacagtgg acctgaataa gctaaacgag attgaaggca   4920

ccctaaacaa agccaaagat gaaatgaagg tcagcgatct tgataggaaa gtgtctgacc   4980

tggagaatga agccaagaag caggaggctg ccatcatgga ctataaccga gatatcgagg   5040

agatcatgaa ggacattcgc aatctggagg acatcaggaa gaccttacca tctggctgct   5100

tcaacacccc gtccattgaa aagccctagt gtctttaggg ctggaaggca gcatccctct   5160

gacagggggg cagttgtgag gccacagagt gccttgacac aaagattaca tttttcagac   5220

ccccactcct ctgctgctgt ccatgactgt ccttttgaac caggaaaagt cacagagttt   5280

aaagagaagc aaattaaaca tcctgaatcg ggaacaaagg gttttatcta ataaagtgtc   5340

tcttccattc acgttgctac cttacccaca ctttcccttc tgatttgcgt gaggacgtgg   5400

catcctacgt tactgtacag tggcataagc acatcgtgtg agcccatgta tgctggggta   5460

gagcaagtag ccctcccctg tctcatcgat accagcagaa cctcctcagt ctcagtactc   5520

ttgtttctat gaaggaaaag tttggctact aacagtagca ttgtgatggc cagtatatcc   5580

agtccatgga taaagaaaat gcatctgcat ctcctacccc tcttccttct aagcaaaagg   5640

aaataaacat cctgtgccaa aggtattggt catttagaat gtcggtagcc atccatcagt   5700

gcttttagtt attatgagtg taggacactg agccatccgt gggtcaggat gcaattattt   5760

ataaaagtct ccaggtgaac atggctgaag atttttctag tatattaata attgactagg   5820

aagatgaact ttttttcaga tctttgggca gctgataatt taaatctgga tgggcagctt   5880

gcactcacca atagaccaaa agacatcttt tgatattctt ataaatggaa cttacacaga   5940

agaaataggg atatgataac cactaaaatt ttgttttcaa aatcaaacta attcttacag   6000

cttttttatt agttagtctt ggaactagtg ttaagtatct ggcagagaac agttaatccc   6060

taaggtcttg acaaaacaga agaaaaacaa gcctcctcgt cctagtcttt tctagcaaag   6120

ggataaaact tagatggcag cttgtactgt cagaatcccg tgtatccatt tgttcttctg   6180

ttggagagat gagacatttg acccttagct ccagttttct tctgatgttt ccatcttcca   6240

gaatccctca aaaaacattg tttgccaaat cctggtggca aatacttgca ctcagtattt   6300

cacacagctg ccaacgctat cgagttcctg cactttgtga tttaaatcca ctctaaacct   6360

tccctctaag tgtagaggga agacccttac gtggagtttc ctagtgggct tctcaacttt   6420

tgatcctcag ctctgtggtt ttaagaccac agtgtgacag ttccctgcca cacaccccct   6480

tcctcctacc aacccacctt tgagattcat atatagcctt taacactatg caactttgta   6540

ctttgcgtag caggggcggg gtggggggaa agaaactatt atctgacaca ctggtgctat   6600

taattatttc aaatttatat ttttgtgtga atgttttgtg ttttgtttat catgattata   6660

gaataaggaa tttatgtaaa tatacttagt cctatttcta gaatgacact ctgttcactt   6720

tgctcaattt ttcctcttca ctggcacaat gtatctgaat acctccttcc ctcccttcta   6780

gaattctttg gattgtactc caaagaattg tgccttgtgt ttgcagcatc tccattctct   6840

aaaattaata taattgcttt cctccacacc cagccactgt aaagaggtaa cttgggtcct   6900

cttccattgc agtcctgatg atcctaacct gcagcacggt ggttttacaa tgttccagag   6960

caggaacgcc aggttgacaa gctatggtag gattaggaaa gtttgctgaa gaggatcttt   7020

gacgccacag tgggactagc caggaatgag ggagaaatgc cctttctggc aattgttgga   7080

gctggatagg taagttttat aagggagtac attttgactg agcacttagg gcatcaggaa   7140

cagtgctact tactgatggg tagactggga gaggtggtgt aacttagttc ttgatgatcc   7200

cacttcctgt ttccatctgc ttgggatata ccagagttta ccacaagtgt tttgacgata   7260

tactcctgag ctttcactct gctgcttctc ccaggcctct tctactatgg caggagatgt   7320

ggcgtgctgt tgcaaagttt tcacgtcatt gtttcctggc tagttcattt cattaagtgg   7380

ctacatccta acatatgcat ttggtcaagg ttgcagaaga ggactgaaga ttgactgcca   7440

agctagtttg ggtgaagttc actccagcaa gtctcaggcc acaatggggt ggtttggttt   7500

ggtttccttt taactttctt tttgttattt gcttttctcc tccacctgtg tggtatattt   7560

tttaagcaga attttatttt ttaaaataaa aggttcttta caagatgata ccttaattac   7620

actcccgcaa cacagccatt attttattgt ctagctccag ttatctgtat tttatgtaat   7680

gtaattgaca ggatggctgc tgcagaatgc tggttgacac agggattatt atactgctat   7740

ttttccctga atttttttcc tttgaattcc aactgtggac cttttatatg tgccttcact   7800

ttagctgttt gccttaatct ctacagcctt gctctccggg gtggttaata aaatgcaaca   7860

cttggcattt ttatgtttta agaaaaacag tattttattt ataataaaat ctgaatattt   7920

gtaacccttt ata                                                      7933


<210>  6826
<211>  1609
<212>  PRT
<213>  Homosapiens

<400>  6826

Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln 
        35                  40                  45              


Arg Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val 
    50                  55                  60                  


Ala Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr 
65                  70                  75                  80  


Gly Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln 
                85                  90                  95      


Pro His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln 
            100                 105                 110         


Ala Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln 
        115                 120                 125             


Tyr Pro Ser Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp 
    130                 135                 140                 


Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe 
145                 150                 155                 160 


Ala Ile Tyr Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly 
            180                 185                 190         


Phe Ile Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu 
        195                 200                 205             


Phe Ser Asp Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr 
    210                 215                 220                 


Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu 
225                 230                 235                 240 


Gln Glu Trp Val Thr Ala Thr Asp Ile Arg Val Thr Leu Asn Arg Leu 
                245                 250                 255     


Asn Thr Phe Gly Asp Glu Val Phe Asn Asp Pro Lys Val Leu Lys Ser 
            260                 265                 270         


Tyr Tyr Tyr Ala Ile Ser Asp Phe Ala Val Gly Gly Arg Cys Lys Cys 
        275                 280                 285             


Asn Gly His Ala Ser Glu Cys Met Lys Asn Glu Phe Asp Lys Leu Val 
    290                 295                 300                 


Cys Asn Cys Lys His Asn Thr Tyr Gly Val Asp Cys Glu Lys Cys Leu 
305                 310                 315                 320 


Pro Phe Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr Ala Glu Ser Ala 
                325                 330                 335     


Ser Glu Cys Leu Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr 
            340                 345                 350         


Phe Asp Pro Glu Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr 
        355                 360                 365             


Asn Cys Gln Asp Asn Thr Asp Gly Ala His Cys Glu Arg Cys Arg Glu 
    370                 375                 380                 


Asn Phe Phe Arg Leu Gly Asn Asn Glu Ala Cys Ser Ser Cys His Cys 
385                 390                 395                 400 


Ser Pro Val Gly Ser Leu Ser Thr Gln Cys Asp Ser Tyr Gly Arg Cys 
                405                 410                 415     


Ser Cys Lys Pro Gly Val Met Gly Asp Lys Cys Asp Arg Cys Gln Pro 
            420                 425                 430         


Gly Phe His Ser Leu Thr Glu Ala Gly Cys Arg Pro Cys Ser Cys Asp 
        435                 440                 445             


Pro Ser Gly Ser Ile Asp Glu Cys Asn Ile Glu Thr Gly Arg Cys Val 
    450                 455                 460                 


Cys Lys Asp Asn Val Glu Gly Phe Asn Cys Glu Arg Cys Lys Pro Gly 
465                 470                 475                 480 


Phe Phe Asn Leu Glu Ser Ser Asn Pro Arg Gly Cys Thr Pro Cys Phe 
                485                 490                 495     


Cys Phe Gly His Ser Ser Val Cys Thr Asn Ala Val Gly Tyr Ser Val 
            500                 505                 510         


Tyr Ser Ile Ser Ser Thr Phe Gln Ile Asp Glu Asp Gly Trp Arg Ala 
        515                 520                 525             


Glu Gln Arg Asp Gly Ser Glu Ala Ser Leu Glu Trp Ser Ser Glu Arg 
    530                 535                 540                 


Gln Asp Ile Ala Val Ile Ser Asp Ser Tyr Phe Pro Arg Tyr Phe Ile 
545                 550                 555                 560 


Ala Pro Ala Lys Phe Leu Gly Lys Gln Val Leu Ser Tyr Gly Gln Asn 
                565                 570                 575     


Leu Ser Phe Ser Phe Arg Val Asp Arg Arg Asp Thr Arg Leu Ser Ala 
            580                 585                 590         


Glu Asp Leu Val Leu Glu Gly Ala Gly Leu Arg Val Ser Val Pro Leu 
        595                 600                 605             


Ile Ala Gln Gly Asn Ser Tyr Pro Ser Glu Thr Thr Val Lys Tyr Val 
    610                 615                 620                 


Phe Arg Leu His Glu Ala Thr Asp Tyr Pro Trp Arg Pro Ala Leu Thr 
625                 630                 635                 640 


Pro Phe Glu Phe Gln Lys Leu Leu Asn Asn Leu Thr Ser Ile Lys Ile 
                645                 650                 655     


Arg Gly Thr Tyr Ser Glu Arg Ser Ala Gly Tyr Leu Asp Asp Val Thr 
            660                 665                 670         


Leu Ala Ser Ala Arg Pro Gly Pro Gly Val Pro Ala Thr Trp Val Glu 
        675                 680                 685             


Ser Cys Thr Cys Pro Val Gly Tyr Gly Gly Gln Phe Cys Glu Met Cys 
    690                 695                 700                 


Leu Ser Gly Tyr Arg Arg Glu Thr Pro Asn Leu Gly Pro Tyr Ser Pro 
705                 710                 715                 720 


Cys Val Leu Cys Ala Cys Asn Gly His Ser Glu Thr Cys Asp Pro Glu 
                725                 730                 735     


Thr Gly Val Cys Asn Cys Arg Asp Asn Thr Ala Gly Pro His Cys Glu 
            740                 745                 750         


Lys Cys Ser Asp Gly Tyr Tyr Gly Asp Ser Thr Ala Gly Thr Ser Ser 
        755                 760                 765             


Asp Cys Gln Pro Cys Pro Cys Pro Gly Gly Ser Ser Cys Ala Val Val 
    770                 775                 780                 


Pro Lys Thr Lys Glu Val Val Cys Thr Asn Cys Pro Thr Gly Thr Thr 
785                 790                 795                 800 


Gly Lys Arg Cys Glu Leu Cys Asp Asp Gly Tyr Phe Gly Asp Pro Leu 
                805                 810                 815     


Gly Arg Asn Gly Pro Val Arg Leu Cys Arg Leu Cys Gln Cys Ser Asp 
            820                 825                 830         


Asn Ile Asp Pro Asn Ala Val Gly Asn Cys Asn Arg Leu Thr Gly Glu 
        835                 840                 845             


Cys Leu Lys Cys Ile Tyr Asn Thr Ala Gly Phe Tyr Cys Asp Arg Cys 
    850                 855                 860                 


Lys Asp Gly Phe Phe Gly Asn Pro Leu Ala Pro Asn Pro Ala Asp Lys 
865                 870                 875                 880 


Cys Lys Ala Cys Asn Cys Asn Leu Tyr Gly Thr Met Lys Gln Gln Ser 
                885                 890                 895     


Ser Cys Asn Pro Val Thr Gly Gln Cys Glu Cys Leu Pro His Val Thr 
            900                 905                 910         


Gly Gln Asp Cys Gly Ala Cys Asp Pro Gly Phe Tyr Asn Leu Gln Ser 
        915                 920                 925             


Gly Gln Gly Cys Glu Arg Cys Asp Cys His Ala Leu Gly Ser Thr Asn 
    930                 935                 940                 


Gly Gln Cys Asp Ile Arg Thr Gly Gln Cys Glu Cys Gln Pro Gly Ile 
945                 950                 955                 960 


Thr Gly Gln His Cys Glu Arg Cys Glu Val Asn His Phe Gly Phe Gly 
                965                 970                 975     


Pro Glu Gly Cys Lys Pro Cys Asp Cys His Pro Glu Gly Ser Leu Ser 
            980                 985                 990         


Leu Gln Cys Lys Asp Asp Gly Arg  Cys Glu Cys Arg Glu  Gly Phe Val 
        995                 1000                 1005             


Gly Asn  Arg Cys Asp Gln Cys  Glu Glu Asn Tyr Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Ser Trp  Pro Gly Cys Gln Glu  Cys Pro Ala Cys Tyr  Arg Leu Val 
    1025                 1030                 1035             


Lys Asp  Lys Val Ala Asp His  Arg Val Lys Leu Gln  Glu Leu Glu 
    1040                 1045                 1050             


Ser Leu  Ile Ala Asn Leu Gly  Thr Gly Asp Glu Met  Val Thr Asp 
    1055                 1060                 1065             


Gln Ala  Phe Glu Asp Arg Leu  Lys Glu Ala Glu Arg  Glu Val Met 
    1070                 1075                 1080             


Asp Leu  Leu Arg Glu Ala Gln  Asp Val Lys Asp Val  Asp Gln Asn 
    1085                 1090                 1095             


Leu Met  Asp Arg Leu Gln Arg  Val Asn Asn Thr Leu  Ser Ser Gln 
    1100                 1105                 1110             


Ile Ser  Arg Leu Gln Asn Ile  Arg Asn Thr Ile Glu  Glu Thr Gly 
    1115                 1120                 1125             


Asn Leu  Ala Glu Gln Ala Arg  Ala His Val Glu Asn  Thr Glu Arg 
    1130                 1135                 1140             


Leu Ile  Glu Ile Ala Ser Arg  Glu Leu Glu Lys Ala  Lys Val Ala 
    1145                 1150                 1155             


Ala Ala  Asn Val Ser Val Thr  Gln Pro Glu Ser Thr  Gly Asp Pro 
    1160                 1165                 1170             


Asn Asn  Met Thr Leu Leu Ala  Glu Glu Ala Arg Lys  Leu Ala Glu 
    1175                 1180                 1185             


Arg His  Lys Gln Glu Ala Asp  Asp Ile Val Arg Val  Ala Lys Thr 
    1190                 1195                 1200             


Ala Asn  Asp Thr Ser Thr Glu  Ala Tyr Asn Leu Leu  Leu Arg Thr 
    1205                 1210                 1215             


Leu Ala  Gly Glu Asn Gln Thr  Ala Phe Glu Ile Glu  Glu Leu Asn 
    1220                 1225                 1230             


Arg Lys  Tyr Glu Gln Ala Lys  Asn Ile Ser Gln Asp  Leu Glu Lys 
    1235                 1240                 1245             


Gln Ala  Ala Arg Val His Glu  Glu Ala Lys Arg Ala  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Glu Ile Tyr Ala Ser  Val Ala Gln Leu Ser  Pro Leu Asp 
    1265                 1270                 1275             


Ser Glu  Thr Leu Glu Asn Glu  Ala Asn Asn Ile Lys  Met Glu Ala 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gln Leu Ile  Asp Gln Lys Leu Lys  Asp Tyr Glu 
    1295                 1300                 1305             


Asp Leu  Arg Glu Asp Met Arg  Gly Lys Glu Leu Glu  Val Lys Asn 
    1310                 1315                 1320             


Leu Leu  Glu Lys Gly Lys Thr  Glu Gln Gln Thr Ala  Asp Gln Leu 
    1325                 1330                 1335             


Leu Ala  Arg Ala Asp Ala Ala  Lys Ala Leu Ala Glu  Glu Ala Ala 
    1340                 1345                 1350             


Lys Lys  Gly Arg Asp Thr Leu  Gln Glu Ala Asn Asp  Ile Leu Asn 
    1355                 1360                 1365             


Asn Leu  Lys Asp Phe Asp Arg  Arg Val Asn Asp Asn  Lys Thr Ala 
    1370                 1375                 1380             


Ala Glu  Glu Ala Leu Arg Lys  Ile Pro Ala Ile Asn  Gln Thr Ile 
    1385                 1390                 1395             


Thr Glu  Ala Asn Glu Lys Thr  Arg Glu Ala Gln Gln  Ala Leu Gly 
    1400                 1405                 1410             


Ser Ala  Ala Ala Asp Ala Thr  Glu Ala Lys Asn Lys  Ala His Glu 
    1415                 1420                 1425             


Ala Glu  Arg Ile Ala Ser Ala  Val Gln Lys Asn Ala  Thr Ser Thr 
    1430                 1435                 1440             


Lys Ala  Glu Ala Glu Arg Thr  Phe Ala Glu Val Thr  Asp Leu Asp 
    1445                 1450                 1455             


Asn Glu  Val Asn Asn Met Leu  Lys Gln Leu Gln Glu  Ala Glu Lys 
    1460                 1465                 1470             


Glu Leu  Lys Arg Lys Gln Asp  Asp Ala Asp Gln Asp  Met Met Met 
    1475                 1480                 1485             


Ala Gly  Met Ala Ser Gln Ala  Ala Gln Glu Ala Glu  Ile Asn Ala 
    1490                 1495                 1500             


Arg Lys  Ala Lys Asn Ser Val  Thr Ser Leu Leu Ser  Ile Ile Asn 
    1505                 1510                 1515             


Asp Leu  Leu Glu Gln Leu Gly  Gln Leu Asp Thr Val  Asp Leu Asn 
    1520                 1525                 1530             


Lys Leu  Asn Glu Ile Glu Gly  Thr Leu Asn Lys Ala  Lys Asp Glu 
    1535                 1540                 1545             


Met Lys  Val Ser Asp Leu Asp  Arg Lys Val Ser Asp  Leu Glu Asn 
    1550                 1555                 1560             


Glu Ala  Lys Lys Gln Glu Ala  Ala Ile Met Asp Tyr  Asn Arg Asp 
    1565                 1570                 1575             


Ile Glu  Glu Ile Met Lys Asp  Ile Arg Asn Leu Glu  Asp Ile Arg 
    1580                 1585                 1590             


Lys Thr  Leu Pro Ser Gly Cys  Phe Asn Thr Pro Ser  Ile Glu Lys 
    1595                 1600                 1605             


Pro 
    


<210>  6827
<211>  856
<212>  DNA
<213>  Homosapiens

<400>  6827
gtgcaggctg ctcccggggt aggtgaggga agcgcggagg cggcgcgcgg gggcagtggt     60

cggcgagcag cgcggtcctc gctaggggcg cccacccgtc agtctctccg gcgcgagccg    120

ccgccaccgc ccgcgccgga gtcaggcccc tgggccccca ggctcaagca gcgaagcggc    180

ctccggggga cgccgctagg cgagaggaac gcgccggtgc ccttgccttc gccgtgaccc    240

agcgtgcggg cggcgggatg agagggagcc atcgggccgc gccggccctg cggccccggg    300

ggcggctctg gcccgtgctg gccgtgctgg cggcggccgc cgcggcgggc tgtgcccagg    360

cagccatgga cgagtgcacg gacgagggcg ggcggccgca gcgctgcatg cccgagttcg    420

tcaacgccgc cttcaacgtg actgtggtgg ccaccaacac gtgtgggact ccgcccgagg    480

aatactgtgt gcagaccggg gtgaccgggg tcaccaagtc ctgtcacctg tgcgacgccg    540

ggcagcccca cctgcagcac ggggcagcct tcctgaccga ctacaacaac caggccgaca    600

ccacctggtg gcaaagccag accatgctgg ccggggtgca gtaccccagc tccatcaacc    660

tcacgctgca cctggatgac acgtggaata aattgcacat taaaatgtct gacatgaaaa    720

tcagaagagc ttaagttcat tccacagaag ccttttgtta gaatcttcaa aggatgagaa    780

ccaggatgaa gaagagttta cagtagggaa gtatttctca actgtaattg tacataaaaa    840

ttgcctatgg tgcttt                                                    856


<210>  6828
<211>  158
<212>  PRT
<213>  Homosapiens

<400>  6828

Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln 
        35                  40                  45              


Arg Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val 
    50                  55                  60                  


Ala Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr 
65                  70                  75                  80  


Gly Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln 
                85                  90                  95      


Pro His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln 
            100                 105                 110         


Ala Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln 
        115                 120                 125             


Tyr Pro Ser Ser Ile Asn Leu Thr Leu His Leu Asp Asp Thr Trp Asn 
    130                 135                 140                 


Lys Leu His Ile Lys Met Ser Asp Met Lys Ile Arg Arg Ala 
145                 150                 155             


<210>  6829
<211>  2394
<212>  DNA
<213>  Homosapiens

<400>  6829
gtgcaggctg ctcccggggt aggtgaggga agcgcggagg cggcgcgcgg gggcagtggt     60

cggcgagcag cgcggtcctc gctaggggcg cccacccgtc agtctctccg gcgcgagccg    120

ccgccaccgc ccgcgccgga gtcaggcccc tgggccccca ggctcaagca gcgaagcggc    180

ctccggggga cgccgctagg cgagaggaac gcgccggtgc ccttgccttc gccgtgaccc    240

agcgtgcggg cggcgggatg agagggagcc atcgggccgc gccggccctg cggccccggg    300

ggcggctctg gcccgtgctg gccgtgctgg cggcggccgc cgcggcgggc tgtgcccagg    360

cagccatgga cgagtgcacg gacgagggcg ggcggccgca gcgctgcatg cccgagttcg    420

tcaacgccgc cttcaacgtg actgtggtgg ccaccaacac gtgtgggact ccgcccgagg    480

aatactgtgt gcagaccggg gtgaccgggg tcaccaagtc ctgtcacctg tgcgacgccg    540

ggcagcccca cctgcagcac ggggcagcct tcctgaccga ctacaacaac caggccgaca    600

ccacctggtg gcaaagccag accatgctgg ccggggtgca gtaccccagc tccatcaacc    660

tcacgctgca cctgggaaaa gcttttgaca tcacctatgt gcgtctcaag ttccacacca    720

gccgcccgga gagctttgcc atttacaagc gcacacggga agacgggccc tggattcctt    780

accagtacta cagtggttcc tgtgagaaca cctactccaa ggcaaaccgc ggcttcatca    840

ggacaggagg ggacgagcag caggccttgt gtactgatga attcagtgac atttctcccc    900

tcactggggg caacgtggcc ttttctaccc tggaaggaag gcccagcgcc tataactttg    960

acaatagccc tgtgctgcag gtaaattctc acaggttggc ctgaagccag ctagttctac   1020

aacatgcgag gtgtgggaag attattgtag tggggcttgt ggtcccactt ctgaggtacg   1080

gggtcagagt agaatacttg agcaacacag acagagagct tgattctgct ctctgtgtac   1140

tattaataag tgaaggaaag tagttttgtt cctgctgcct ggttgatgtt tgttcttatg   1200

cacttgcaga tctattctgg gatgtaaact ttacacattt tttaaaaagt caaacaattt   1260

taacgttagt ctctgtacct gaggtggaaa cattttcctt ctgacctttt gaagagaaca   1320

tttgacctaa ttacccagat ttcttggatc ttttcttgcc tattttttga tttgacaaaa   1380

taaaatgtat tttttaaaat tagcaaaggg gaaccgttga agcaagatat ttaagaatgc   1440

catcttcttt catttttaca caagaaaatt ttgattagat ttgtctggca cgattgctga   1500

tcattaaaga aactcctcat cacctaaaat ggatgatgtt agtaacagga tatggatgtt   1560

agtaacagga tattaattta ggtacccata gcactgtact taaacattgt gatagaaacc   1620

tttccctgtt tgagaaggat ttcttttttc tcctgaattc tacatgcata ttccttatac   1680

accataatac ggaattcttc tatgttgctc atatttctgt gaacttttca tatgtcctgg   1740

ctatttgatt atggaaaagc tggtgagcct catgctgtac tcagcacttt aacacagaat   1800

tggagatgct gctgcatgtg gctgaagtca acaaccacat ggggatagcc tttgtcagtt   1860

gactgaaaca agaaagtctg ataatgggtt ttcaaatgct gtgtacatta tatgaaaagc   1920

tattgtgatt tctaaatagg aaatacccca tttttctagg gtttctaatt tggatcttct   1980

tattctttct caccgttatt atgttcaggg actctctttc taattgtatg gttttggaca   2040

gtgacaaaag ataagaatat atttttctgt gggttcagtt gccccccttc cattgtattt   2100

ctgtaagttg ctgggaaagc atgaatgtga aagctgttgg taaactctga ggttatggtg   2160

agcaatgagt gtgcttgcca acaccttgca aaaaagtgtt tcttgcaatg gagataagtt   2220

gtgttcaaaa taaatggccg agagaatagc tgattttgat agatgaaaaa gcagggccag   2280

gcgcagtggc tcatggctgt aataccagca ctttgggagg cggaggcagg tggatcactt   2340

gaggtcaggc attcaaaacc cacctggcca acatggtgaa accctgtctc tact         2394


<210>  6830
<211>  248
<212>  PRT
<213>  Homosapiens

<400>  6830

Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln 
        35                  40                  45              


Arg Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val 
    50                  55                  60                  


Ala Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr 
65                  70                  75                  80  


Gly Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln 
                85                  90                  95      


Pro His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln 
            100                 105                 110         


Ala Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln 
        115                 120                 125             


Tyr Pro Ser Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp 
    130                 135                 140                 


Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe 
145                 150                 155                 160 


Ala Ile Tyr Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly 
            180                 185                 190         


Phe Ile Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu 
        195                 200                 205             


Phe Ser Asp Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr 
    210                 215                 220                 


Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu 
225                 230                 235                 240 


Gln Val Asn Ser His Arg Leu Ala 
                245             


<210>  6831
<211>  5321
<212>  DNA
<213>  Homosapiens

<400>  6831
gtgcaggctg ctcccggggt aggtgaggga agcgcggagg cggcgcgcgg gggcagtggt     60

cggcgagcag cgcggtcctc gctaggggcg cccacccgtc agtctctccg gcgcgagccg    120

ccgccaccgc ccgcgccgga gtcaggcccc tgggccccca ggctcaagca gcgaagcggc    180

ctccggggga cgccgctagg cgagaggaac gcgccggtgc ccttgccttc gccgtgaccc    240

agcgtgcggg cggcgggatg agagggagcc atcgggccgc gccggccctg cggccccggg    300

ggcggctctg gcccgtgctg gccgtgctgg cggcggccgc cgcggcgggc tgtgcccagg    360

cagccatgga cgagtgcacg gacgagggcg ggcggccgca gcgctgcatg cccgagttcg    420

tcaacgccgc cttcaacgtg actgtggtgg ccaccaacac gtgtgggact ccgcccgagg    480

aatactgtgt gcagaccggg gtgaccgggg tcaccaagtc ctgtcacctg tgcgacgccg    540

ggcagcccca cctgcagcac ggggcagcct tcctgaccga ctacaacaac caggccgaca    600

ccacctggtg gcaaagccag accatgctgg ccggggtgca gtaccccagc tccatcaacc    660

tcacgctgca cctgggaaaa gcttttgaca tcacctatgt gcgtctcaag ttccacacca    720

gccgcccgga gagctttgcc atttacaagc gcacacggga agacgggccc tggattcctt    780

accagtacta cagtggttcc tgtgagaaca cctactccaa ggcaaaccgc ggcttcatca    840

ggacaggagg ggacgagcag caggccttgt gtactgatga attcagtgac atttctcccc    900

tcactggggg caacgtggcc ttttctaccc tggaaggaag gcccagcgcc tataactttg    960

acaatagccc tgtgctgcag gaatgggtaa ctgccactga catcagagta actcttaatc   1020

gcctgaacac ttttggagat gaagtgttta acgatcccaa agttctcaag tcctattatt   1080

atgccatctc tgattttgct gtaggtggca gatgtaaatg taatggacac gcaagcgagt   1140

gtatgaagaa cgaatttgat aagctggtgt gtaattgcaa acataacaca tatggagtag   1200

actgtgaaaa gtgtcttcct ttcttcaatg accggccgtg gaggagggca actgcggaaa   1260

gtgccagtga atgcctgccc tgtgattgca atggtcgatc ccaggaatgc tacttcgacc   1320

ctgaactcta tcgttccact ggccatgggg gccactgtac caactgccag gataacacag   1380

atggcgccca ctgtgagagg tgccgagaga acttcttccg ccttggcaac aatgaagcct   1440

gctcttcatg ccactgtagt cctgtgggct ctctaagcac acagtgtgat agttacggca   1500

gatgcagctg taagccagga gtgatggggg acaaatgtga ccgttgccag cctggattcc   1560

attctctcac tgaagcagga tgcaggccat gctcttgtga tccctctggc agcatagatg   1620

aatgtaatat tgaaacagga agatgtgttt gcaaagacaa tgtcgaaggc ttcaattgtg   1680

aaagatgcaa acctggattt tttaatctgg aatcatctaa tcctcggggt tgcacaccct   1740

gcttctgctt tgggcattct tctgtctgta caaacgctgt tggctacagt gtttattcta   1800

tctcctctac ctttcagatt gatgaggatg ggtggcgtgc ggaacagaga gatggctctg   1860

aagcatctct cgagtggtcc tctgagaggc aagatatcgc cgtgatctca gacagctact   1920

ttcctcggta cttcattgct cctgcaaagt tcttgggcaa gcaggtgttg agttatggtc   1980

agaacctctc cttctccttt cgagtggaca ggcgagatac tcgcctctct gcagaagacc   2040

ttgtgcttga gggagctggc ttaagagtat ctgtaccctt gatcgctcag ggcaattcct   2100

atccaagtga gaccactgtg aagtatgtct tcaggctcca tgaagcaaca gattaccctt   2160

ggaggcctgc tcttacccct tttgaatttc agaagctcct aaacaacttg acctctatca   2220

agatacgtgg gacatacagt gagagaagtg ctggatattt ggatgatgtc accctggcaa   2280

gtgctcgtcc tgggcctgga gtccctgcaa cttgggtgga gtcctgcacc tgtcctgtgg   2340

gatatggagg gcagttttgt gagatgtgcc tctcaggtta cagaagagaa actcctaatc   2400

ttggaccata cagtccatgt gtgctttgcg cctgcaatgg acacagcgag acctgtgatc   2460

ctgagacagg tgtttgtaac tgcagagaca atacggctgg cccgcactgt gagaagtgca   2520

gtgatgggta ctatggagat tcaactgcag gcacctcctc cgattgccaa ccctgtccgt   2580

gtcctggagg ttcaagttgt gctgttgttc ccaagacaaa ggaggtggtg tgcaccaact   2640

gtcctactgg caccactggt aagagatgtg agctctgtga tgatggctac tttggagacc   2700

ccctgggtag aaacggccct gtgagacttt gccgcctgtg ccagtgcagt gacaacatcg   2760

atcccaatgc agttggaaat tgcaatcgct tgacgggaga atgcctgaag tgcatctata   2820

acactgctgg cttctattgt gaccggtgca aagacggatt ttttggaaat cccctggctc   2880

ccaatccagc agacaaatgc aaagcctgca attgcaatct gtatgggacc atgaagcagc   2940

agagcagctg taaccccgtg acggggcagt gtgaatgttt gcctcacgtg actggccagg   3000

actgtggtgc ttgtgaccct ggattctaca atctgcagag tgggcaaggc tgtgagaggt   3060

gtgactgcca tgccttgggc tccaccaatg ggcagtgtga catccgcacc ggccagtgtg   3120

agtgccagcc cggcatcact ggtcagcact gtgagcgctg tgaggtcaac cactttgggt   3180

ttggacctga aggctgcaaa ccctgtgact gtcatcctga gggatctctt tcacttcagt   3240

gcaaagatga tggtcgctgt gaatgcagag aaggctttgt gggaaatcgc tgtgaccagt   3300

gtgaagaaaa ctatttctac aatcggtctt ggcctggctg ccaggaatgt ccagcttgtt   3360

accggctggt aaaggataag gttgctgatc atagagtgaa gctccaggaa ttagagagtc   3420

tcatagcaaa ccttggaact ggggatgaga tggtgacaga tcaagccttc gaggatagac   3480

taaaggaagc agagagggaa gttatggacc tccttcgtga ggcccaggat gtcaaagatg   3540

ttgaccagaa tttgatggat cgcctacaga gagtgaataa cactctgtcc agccaaatta   3600

gccgtttaca gaatatccgg aataccattg aagagactgg aaacttggct gaacaagcgc   3660

gtgcccatgt agagaacaca gagcggttga ttgaaatcgc atccagagaa cttgagaaag   3720

caaaagtcgc tgctgccaat gtgtcagtca ctcagccaga atctacaggg gacccaaaca   3780

acatgactct tttggcagaa gaggctcgaa agcttgctga acgtcataaa caggaagctg   3840

atgacattgt tcgagtggca aagacagcca atgatacgtc aactgaggca tacaacctgc   3900

ttctgaggac actggcagga gaaaatcaaa cagcatttga gattgaagag cttaatagga   3960

agtatgaaca agcgaagaac atctcacagg atctggaaaa acaagctgcc cgagtacatg   4020

aggaggccaa aagggccggt gacaaagctg tggagatcta tgccagcgtg gctcagctga   4080

gccctttgga ctctgagaca ctggagaatg aagcaaataa cataaagatg gaagctgaga   4140

atctggaaca actgattgac cagaaattaa aagattatga ggacctcaga gaagatatga   4200

gagggaagga acttgaagtc aagaaccttc tggagaaagg caagactgaa cagcagaccg   4260

cagaccaact cctagcccga gctgatgctg ccaaggccct cgctgaagaa gctgcaaaga   4320

agggacggga taccttacaa gaagctaatg acattctcaa caacctgaaa gattttgata   4380

ggcgtgtgaa cgataacaag acggccgcag aggaggcact aaggaagatt cctgccatca   4440

accagaccat cactgaagcc aatgaaaaga ccagagaagc ccagcaggcc ctgggcagtg   4500

ctgcggcgga tgccacagag gccaagaaca aggcccatga ggcggagagg atcgcgagcg   4560

ctgtccaaaa gaatgccacc agcaccaagg cagaagctga aagaactttt gcagaagtta   4620

cagatctgga taatgaggtg aacaatatgt tgaagcaact gcaggaagca gaaaaagagc   4680

taaagagaaa acaagatgac gctgaccagg acatgatgat ggcagggatg gcttcacagg   4740

ctgctcaaga agccgagatc aatgccagaa aagccaaaaa ctctgttact agcctcctca   4800

gcattattaa tgacctcttg gagcagctgg ggcagctgga tacagtggac ctgaataagc   4860

taaacgagat tgaaggcacc ctaaacaaag ccaaagatga aatgaaggtc agcgatcttg   4920

ataggaaagt gtctgacctg gagaatgaag ccaagaagca ggaggctgcc atcatggact   4980

ataaccgaga tatcgaggag atcatgaagg acattcgcaa tctggaggac atcaggaaga   5040

ccttaccatc tggctgcttc aacaccccgt ccattgaaaa gccctagtgt ctttagggct   5100

ggaaggcagc atccctctga caggggggca gttgtgaggc cacagagtgc cttgacacaa   5160

agattacatt tttcagaccc ccactcctct gctgctgtcc atgactgtcc ttttgaacca   5220

ggaaaagtca cagagtttaa agagaagcaa attaaacatc ctgaatcggg aacaaagggt   5280

tttatctaat aaagtgtctc ttccattcac gttgctacct t                       5321


<210>  6832
<211>  1609
<212>  PRT
<213>  Homosapiens

<400>  6832

Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln 
        35                  40                  45              


Arg Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val 
    50                  55                  60                  


Ala Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr 
65                  70                  75                  80  


Gly Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln 
                85                  90                  95      


Pro His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln 
            100                 105                 110         


Ala Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln 
        115                 120                 125             


Tyr Pro Ser Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp 
    130                 135                 140                 


Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe 
145                 150                 155                 160 


Ala Ile Tyr Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly 
            180                 185                 190         


Phe Ile Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu 
        195                 200                 205             


Phe Ser Asp Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr 
    210                 215                 220                 


Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu 
225                 230                 235                 240 


Gln Glu Trp Val Thr Ala Thr Asp Ile Arg Val Thr Leu Asn Arg Leu 
                245                 250                 255     


Asn Thr Phe Gly Asp Glu Val Phe Asn Asp Pro Lys Val Leu Lys Ser 
            260                 265                 270         


Tyr Tyr Tyr Ala Ile Ser Asp Phe Ala Val Gly Gly Arg Cys Lys Cys 
        275                 280                 285             


Asn Gly His Ala Ser Glu Cys Met Lys Asn Glu Phe Asp Lys Leu Val 
    290                 295                 300                 


Cys Asn Cys Lys His Asn Thr Tyr Gly Val Asp Cys Glu Lys Cys Leu 
305                 310                 315                 320 


Pro Phe Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr Ala Glu Ser Ala 
                325                 330                 335     


Ser Glu Cys Leu Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr 
            340                 345                 350         


Phe Asp Pro Glu Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr 
        355                 360                 365             


Asn Cys Gln Asp Asn Thr Asp Gly Ala His Cys Glu Arg Cys Arg Glu 
    370                 375                 380                 


Asn Phe Phe Arg Leu Gly Asn Asn Glu Ala Cys Ser Ser Cys His Cys 
385                 390                 395                 400 


Ser Pro Val Gly Ser Leu Ser Thr Gln Cys Asp Ser Tyr Gly Arg Cys 
                405                 410                 415     


Ser Cys Lys Pro Gly Val Met Gly Asp Lys Cys Asp Arg Cys Gln Pro 
            420                 425                 430         


Gly Phe His Ser Leu Thr Glu Ala Gly Cys Arg Pro Cys Ser Cys Asp 
        435                 440                 445             


Pro Ser Gly Ser Ile Asp Glu Cys Asn Ile Glu Thr Gly Arg Cys Val 
    450                 455                 460                 


Cys Lys Asp Asn Val Glu Gly Phe Asn Cys Glu Arg Cys Lys Pro Gly 
465                 470                 475                 480 


Phe Phe Asn Leu Glu Ser Ser Asn Pro Arg Gly Cys Thr Pro Cys Phe 
                485                 490                 495     


Cys Phe Gly His Ser Ser Val Cys Thr Asn Ala Val Gly Tyr Ser Val 
            500                 505                 510         


Tyr Ser Ile Ser Ser Thr Phe Gln Ile Asp Glu Asp Gly Trp Arg Ala 
        515                 520                 525             


Glu Gln Arg Asp Gly Ser Glu Ala Ser Leu Glu Trp Ser Ser Glu Arg 
    530                 535                 540                 


Gln Asp Ile Ala Val Ile Ser Asp Ser Tyr Phe Pro Arg Tyr Phe Ile 
545                 550                 555                 560 


Ala Pro Ala Lys Phe Leu Gly Lys Gln Val Leu Ser Tyr Gly Gln Asn 
                565                 570                 575     


Leu Ser Phe Ser Phe Arg Val Asp Arg Arg Asp Thr Arg Leu Ser Ala 
            580                 585                 590         


Glu Asp Leu Val Leu Glu Gly Ala Gly Leu Arg Val Ser Val Pro Leu 
        595                 600                 605             


Ile Ala Gln Gly Asn Ser Tyr Pro Ser Glu Thr Thr Val Lys Tyr Val 
    610                 615                 620                 


Phe Arg Leu His Glu Ala Thr Asp Tyr Pro Trp Arg Pro Ala Leu Thr 
625                 630                 635                 640 


Pro Phe Glu Phe Gln Lys Leu Leu Asn Asn Leu Thr Ser Ile Lys Ile 
                645                 650                 655     


Arg Gly Thr Tyr Ser Glu Arg Ser Ala Gly Tyr Leu Asp Asp Val Thr 
            660                 665                 670         


Leu Ala Ser Ala Arg Pro Gly Pro Gly Val Pro Ala Thr Trp Val Glu 
        675                 680                 685             


Ser Cys Thr Cys Pro Val Gly Tyr Gly Gly Gln Phe Cys Glu Met Cys 
    690                 695                 700                 


Leu Ser Gly Tyr Arg Arg Glu Thr Pro Asn Leu Gly Pro Tyr Ser Pro 
705                 710                 715                 720 


Cys Val Leu Cys Ala Cys Asn Gly His Ser Glu Thr Cys Asp Pro Glu 
                725                 730                 735     


Thr Gly Val Cys Asn Cys Arg Asp Asn Thr Ala Gly Pro His Cys Glu 
            740                 745                 750         


Lys Cys Ser Asp Gly Tyr Tyr Gly Asp Ser Thr Ala Gly Thr Ser Ser 
        755                 760                 765             


Asp Cys Gln Pro Cys Pro Cys Pro Gly Gly Ser Ser Cys Ala Val Val 
    770                 775                 780                 


Pro Lys Thr Lys Glu Val Val Cys Thr Asn Cys Pro Thr Gly Thr Thr 
785                 790                 795                 800 


Gly Lys Arg Cys Glu Leu Cys Asp Asp Gly Tyr Phe Gly Asp Pro Leu 
                805                 810                 815     


Gly Arg Asn Gly Pro Val Arg Leu Cys Arg Leu Cys Gln Cys Ser Asp 
            820                 825                 830         


Asn Ile Asp Pro Asn Ala Val Gly Asn Cys Asn Arg Leu Thr Gly Glu 
        835                 840                 845             


Cys Leu Lys Cys Ile Tyr Asn Thr Ala Gly Phe Tyr Cys Asp Arg Cys 
    850                 855                 860                 


Lys Asp Gly Phe Phe Gly Asn Pro Leu Ala Pro Asn Pro Ala Asp Lys 
865                 870                 875                 880 


Cys Lys Ala Cys Asn Cys Asn Leu Tyr Gly Thr Met Lys Gln Gln Ser 
                885                 890                 895     


Ser Cys Asn Pro Val Thr Gly Gln Cys Glu Cys Leu Pro His Val Thr 
            900                 905                 910         


Gly Gln Asp Cys Gly Ala Cys Asp Pro Gly Phe Tyr Asn Leu Gln Ser 
        915                 920                 925             


Gly Gln Gly Cys Glu Arg Cys Asp Cys His Ala Leu Gly Ser Thr Asn 
    930                 935                 940                 


Gly Gln Cys Asp Ile Arg Thr Gly Gln Cys Glu Cys Gln Pro Gly Ile 
945                 950                 955                 960 


Thr Gly Gln His Cys Glu Arg Cys Glu Val Asn His Phe Gly Phe Gly 
                965                 970                 975     


Pro Glu Gly Cys Lys Pro Cys Asp Cys His Pro Glu Gly Ser Leu Ser 
            980                 985                 990         


Leu Gln Cys Lys Asp Asp Gly Arg  Cys Glu Cys Arg Glu  Gly Phe Val 
        995                 1000                 1005             


Gly Asn  Arg Cys Asp Gln Cys  Glu Glu Asn Tyr Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Ser Trp  Pro Gly Cys Gln Glu  Cys Pro Ala Cys Tyr  Arg Leu Val 
    1025                 1030                 1035             


Lys Asp  Lys Val Ala Asp His  Arg Val Lys Leu Gln  Glu Leu Glu 
    1040                 1045                 1050             


Ser Leu  Ile Ala Asn Leu Gly  Thr Gly Asp Glu Met  Val Thr Asp 
    1055                 1060                 1065             


Gln Ala  Phe Glu Asp Arg Leu  Lys Glu Ala Glu Arg  Glu Val Met 
    1070                 1075                 1080             


Asp Leu  Leu Arg Glu Ala Gln  Asp Val Lys Asp Val  Asp Gln Asn 
    1085                 1090                 1095             


Leu Met  Asp Arg Leu Gln Arg  Val Asn Asn Thr Leu  Ser Ser Gln 
    1100                 1105                 1110             


Ile Ser  Arg Leu Gln Asn Ile  Arg Asn Thr Ile Glu  Glu Thr Gly 
    1115                 1120                 1125             


Asn Leu  Ala Glu Gln Ala Arg  Ala His Val Glu Asn  Thr Glu Arg 
    1130                 1135                 1140             


Leu Ile  Glu Ile Ala Ser Arg  Glu Leu Glu Lys Ala  Lys Val Ala 
    1145                 1150                 1155             


Ala Ala  Asn Val Ser Val Thr  Gln Pro Glu Ser Thr  Gly Asp Pro 
    1160                 1165                 1170             


Asn Asn  Met Thr Leu Leu Ala  Glu Glu Ala Arg Lys  Leu Ala Glu 
    1175                 1180                 1185             


Arg His  Lys Gln Glu Ala Asp  Asp Ile Val Arg Val  Ala Lys Thr 
    1190                 1195                 1200             


Ala Asn  Asp Thr Ser Thr Glu  Ala Tyr Asn Leu Leu  Leu Arg Thr 
    1205                 1210                 1215             


Leu Ala  Gly Glu Asn Gln Thr  Ala Phe Glu Ile Glu  Glu Leu Asn 
    1220                 1225                 1230             


Arg Lys  Tyr Glu Gln Ala Lys  Asn Ile Ser Gln Asp  Leu Glu Lys 
    1235                 1240                 1245             


Gln Ala  Ala Arg Val His Glu  Glu Ala Lys Arg Ala  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Glu Ile Tyr Ala Ser  Val Ala Gln Leu Ser  Pro Leu Asp 
    1265                 1270                 1275             


Ser Glu  Thr Leu Glu Asn Glu  Ala Asn Asn Ile Lys  Met Glu Ala 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gln Leu Ile  Asp Gln Lys Leu Lys  Asp Tyr Glu 
    1295                 1300                 1305             


Asp Leu  Arg Glu Asp Met Arg  Gly Lys Glu Leu Glu  Val Lys Asn 
    1310                 1315                 1320             


Leu Leu  Glu Lys Gly Lys Thr  Glu Gln Gln Thr Ala  Asp Gln Leu 
    1325                 1330                 1335             


Leu Ala  Arg Ala Asp Ala Ala  Lys Ala Leu Ala Glu  Glu Ala Ala 
    1340                 1345                 1350             


Lys Lys  Gly Arg Asp Thr Leu  Gln Glu Ala Asn Asp  Ile Leu Asn 
    1355                 1360                 1365             


Asn Leu  Lys Asp Phe Asp Arg  Arg Val Asn Asp Asn  Lys Thr Ala 
    1370                 1375                 1380             


Ala Glu  Glu Ala Leu Arg Lys  Ile Pro Ala Ile Asn  Gln Thr Ile 
    1385                 1390                 1395             


Thr Glu  Ala Asn Glu Lys Thr  Arg Glu Ala Gln Gln  Ala Leu Gly 
    1400                 1405                 1410             


Ser Ala  Ala Ala Asp Ala Thr  Glu Ala Lys Asn Lys  Ala His Glu 
    1415                 1420                 1425             


Ala Glu  Arg Ile Ala Ser Ala  Val Gln Lys Asn Ala  Thr Ser Thr 
    1430                 1435                 1440             


Lys Ala  Glu Ala Glu Arg Thr  Phe Ala Glu Val Thr  Asp Leu Asp 
    1445                 1450                 1455             


Asn Glu  Val Asn Asn Met Leu  Lys Gln Leu Gln Glu  Ala Glu Lys 
    1460                 1465                 1470             


Glu Leu  Lys Arg Lys Gln Asp  Asp Ala Asp Gln Asp  Met Met Met 
    1475                 1480                 1485             


Ala Gly  Met Ala Ser Gln Ala  Ala Gln Glu Ala Glu  Ile Asn Ala 
    1490                 1495                 1500             


Arg Lys  Ala Lys Asn Ser Val  Thr Ser Leu Leu Ser  Ile Ile Asn 
    1505                 1510                 1515             


Asp Leu  Leu Glu Gln Leu Gly  Gln Leu Asp Thr Val  Asp Leu Asn 
    1520                 1525                 1530             


Lys Leu  Asn Glu Ile Glu Gly  Thr Leu Asn Lys Ala  Lys Asp Glu 
    1535                 1540                 1545             


Met Lys  Val Ser Asp Leu Asp  Arg Lys Val Ser Asp  Leu Glu Asn 
    1550                 1555                 1560             


Glu Ala  Lys Lys Gln Glu Ala  Ala Ile Met Asp Tyr  Asn Arg Asp 
    1565                 1570                 1575             


Ile Glu  Glu Ile Met Lys Asp  Ile Arg Asn Leu Glu  Asp Ile Arg 
    1580                 1585                 1590             


Lys Thr  Leu Pro Ser Gly Cys  Phe Asn Thr Pro Ser  Ile Glu Lys 
    1595                 1600                 1605             


Pro 
    


<210>  6833
<211>  382
<212>  DNA
<213>  Homosapiens

<400>  6833
cctgcagcac agggctattg tcaaagttat aggcgctggg ccttccttcc agggtagaaa     60

aggccacgtt gcccccagtg aggggagaaa tgtcactgaa ttcatcagta cacaaggcct    120

gctgctcgtc ccctcctgtc ctgatgaagc cgcggtttgc cttggagtag gtgttctcac    180

aggaaccact gtatcggtca ggaaggctgc cccgtgctgc aggtggggct gcccggcgtc    240

gcacaggtga caggacttgg tgaccccggt caccccggtc tgcacacagt attcctcggg    300

cggagtccca cacgtgttgg tggccaccac agtcacgttg aaggcggcgt tgacgaactc    360

gggcatgcag cgctgcggcc gc                                             382


<210>  6834
<211>  82
<212>  PRT
<213>  Homosapiens

<400>  6834

Leu Gln His Arg Ala Ile Val Lys Val Ile Gly Ala Gly Pro Ser Phe 
1               5                   10                  15      


Gln Gly Arg Lys Gly His Val Ala Pro Ser Glu Gly Arg Asn Val Thr 
            20                  25                  30          


Glu Phe Ile Ser Thr Gln Gly Leu Leu Leu Val Pro Ser Cys Pro Asp 
        35                  40                  45              


Glu Ala Ala Val Cys Leu Gly Val Gly Val Leu Thr Gly Thr Thr Val 
    50                  55                  60                  


Ser Val Arg Lys Ala Ala Pro Cys Cys Arg Trp Gly Cys Pro Ala Ser 
65                  70                  75                  80  


His Arg 
        


<210>  6835
<211>  5883
<212>  DNA
<213>  Homosapiens

<400>  6835
accacctgat caaggaaaag gaaggcacag cggagcgcag agtgagaacc accaaccgag     60

gcgccgggca gcgacccctg cagcggagac agagactgag cggcccggcc ccgccatgcc    120

tgcgctctgg ctgggctgct gcctctgctt ctcgctcctc ctgcccgcag cccgggccac    180

ctccaggagg gaagtctgtg attgcaatgg gaagtccagg cagtgtatct ttgatcggga    240

acttcacaga caaactggta atggattccg ctgcctcaac tgcaatgaca acactgatgg    300

cattcactgc gagaagtgca agaatggctt ttaccggcac agagaaaggg accgctgttt    360

gccctgcaat tgtaactcca aaggttctct tagtgctcga tgtgacaact ccggacggtg    420

cagctgtaaa ccaggtgtga caggagccag atgcgaccga tgtctgccag gcttccacat    480

gctcacggat gcggggtgca cccaagacca gagactgcta gactccaagt gtgactgtga    540

cccagctggc atcgcagggc cctgtgacgc gggccgctgt gtctgcaagc cagctgtcac    600

tggagaacgc tgtgataggt gtcgatcagg ttactataat ctggatgggg ggaaccctga    660

gggctgtacc cagtgtttct gctatgggca ttcagccagc tgccgcagct ctgcagaata    720

cagtgtccat aagatcacct ctacctttca tcaagatgtt gatggctgga aggctgtcca    780

acgaaatggg tctcctgcaa agctccaatg gtcacagcgc catcaagatg tgtttagctc    840

agcccaacga ctagaccctg tctattttgt ggctcctgcc aaatttcttg ggaatcaaca    900

ggtgagctat ggtcaaagcc tgtcctttga ctaccgtgtg gacagaggag gcagacaccc    960

atctgcccat gatgtgattc tggaaggtgc tggtctacgg atcacagctc ccttgatgcc   1020

acttggcaag acactgcctt gtgggctcac caagacttac acattcaggt taaatgagca   1080

tccaagcaat aattggagcc cccagctgag ttactttgag tatcgaaggt tactgcggaa   1140

tctcacagcc ctccgcatcc gagctacata tggagaatac agtactgggt acattgacaa   1200

tgtgaccctg atttcagccc gccctgtctc tggagcccca gcaccctggg ttgaacagtg   1260

tatatgtcct gttgggtaca aggggcaatt ctgccaggat tgtgcttctg gctacaagag   1320

agattcagcg agactggggc cttttggcac ctgtattcct tgtaactgtc aagggggagg   1380

ggcctgtgat ccagacacag gagattgtta ttcaggggat gagaatcctg acattgagtg   1440

tgctgactgc ccaattggtt tctacaacga tccgcacgac ccccgcagct gcaagccatg   1500

tccctgtcat aacgggttca gctgctcagt gatgccggag acggaggagg tggtgtgcaa   1560

taactgccct cccggggtca ccggtgcccg ctgtgagctc tgtgctgatg gctactttgg   1620

ggaccccttt ggtgaacatg gcccagtgag gccttgtcag ccctgtcaat gcaacaacaa   1680

tgtggacccc agtgcctctg ggaattgtga ccggctgaca ggcaggtgtt tgaagtgtat   1740

ccacaacaca gccggcatct actgcgacca gtgcaaagca ggctacttcg gggacccatt   1800

ggctcccaac ccagcagaca agtgtcgagc ttgcaactgt aaccccatgg gctcagagcc   1860

tgtaggatgt cgaagtgatg gcacctgtgt ttgcaagcca ggatttggtg gccccaactg   1920

tgagcatgga gcattcagct gtccagcttg ctataatcaa gtgaagattc agatggatca   1980

gtttatgcag cagcttcaga gaatggaggc cctgatttca aaggctcagg gtggtgatgg   2040

agtagtacct gatacagagc tggaaggcag gatgcagcag gctgagcagg cccttcagga   2100

cattctgaga gatgcccaga tttcagaagg tgctagcaga tcccttggtc tccagttggc   2160

caaggtgagg agccaagaga acagctacca gagccgcctg gatgacctca agatgactgt   2220

ggaaagagtt cgggctctgg gaagtcagta ccagaaccga gttcgggata ctcacaggct   2280

catcactcag atgcagctga gcctggcaga aagtgaagct tccttgggaa acactaacat   2340

tcctgcctca gaccactacg tggggccaaa tggctttaaa agtctggctc aggaggccac   2400

aagattagca gaaagccacg ttgagtcagc cagtaacatg gagcaactga caagggaaac   2460

tgaggactat tccaaacaag ccctctcact ggtgcgcaag gccctgcatg aaggagtcgg   2520

aagcggaagc ggtagcccgg acggtgctgt ggtgcaaggg cttgtggaaa aattggagaa   2580

aaccaagtcc ctggcccagc agttgacaag ggaggccact caagcggaaa ttgaagcaga   2640

taggtcttat cagcacagtc tccgcctcct ggattcagtg tctcggcttc agggagtcag   2700

tgatcagtcc tttcaggtgg aagaagcaaa gaggatcaaa caaaaagcgg attcactctc   2760

aagcctggta accaggcata tggatgagtt caagcgtaca cagaagaatc tgggaaactg   2820

gaaagaagaa gcacagcagc tcttacagaa tggaaaaagt gggagagaga aatcagatca   2880

gctgctttcc cgtgccaatc ttgctaaaag cagagcacaa gaagcactga gtatgggcaa   2940

tgccactttt tatgaagttg agagcatcct taaaaacctc agagagtttg acctgcaggt   3000

ggacaacaga aaagcagaag ctgaagaagc catgaagaga ctctcctaca tcagccagaa   3060

ggtttcagat gccagtgaca agacccagca agcagaaaga gccctgggga gcgctgctgc   3120

tgatgcacag agggcaaaga atggggccgg ggaggccctg gaaatctcca gtgagattga   3180

acaggagatt gggagtctga acttggaagc caatgtgaca gcagatggag ccttggccat   3240

ggaaaaggga ctggcctctc tgaagagtga gatgagggaa gtggaaggag agctggaaag   3300

gaaggagctg gagtttgaca cgaatatgga tgcagtacag atggtgatta cagaagccca   3360

gaaggttgat accagagcca agaacgctgg ggttacaatc caagacacac tcaacacatt   3420

agacggcctc ctgcatctga tgggtatgtg aacccacaac ccacaacctt ccagctccat   3480

gctccagggc tttgctccag aacactcact atacctagcc ccagcaaagg ggagtctcag   3540

ctttccttaa ggatatcagt aaatgtgctt tgtttccagg cccagataac tttcggcagg   3600

ttcccttaca tttactggac cctgttttac cgttgctaag atgggtcact gaacacctat   3660

tgcacttggg ggtaaaggtc tgtgggccaa agaacaggtg tatataagca acttcacaga   3720

acacgagaca gcttgggaat cctgctaaag agtctggcct ggaccctgag aagccagtgg   3780

acagttttaa gcagaggaat aacatcacca ctgtatattt cagaaagatc actagggcag   3840

ccgagtggag gaaagcttga agagggggtt agagagaagg caggttgaga ctacttaaga   3900

tattgttgaa ataattgaag agagaaatga caggagcctg ctctaaggca gtagaatggt   3960

ggctgggaag atgtgaagga agattttccc agtctgtgaa gtcaagaatc acttgccggc   4020

cgggtgtggt ggctcacgcc tgtaattcta gcactttggg agactgaagc gggtggatca   4080

cccgaggtca ggagttgaag accagcctgg ccaacatggt gaaaccctgt ctctactaaa   4140

agtacaaaaa ttagctggat gtggtggtgg gcgcctgtaa ttccagctac tcaggagtct   4200

gaggcaggag aatcgcttga acccaggagg cggaggttac agtgagccaa gattgcacca   4260

ctgctctcca gcctggggaa cagagcaaga ctgtctcaaa aaaaaaaaaa aaaggaaaaa   4320

taaaaaagaa tcacttgccg attttacatt tgttcctccc caaaccaaag ttataccttg   4380

atgtaaccag tgggaggaac ttgagctgct tgggtaaata acccagaaga aatgtgatga   4440

gagtaggcct gtgagataat tttaggaaga tctgatggca cagcgtggaa gaaaatcagg   4500

tttccctaca gaatcgctcc caaaagaaaa cttattttgg ttaaatttct ggatttaggt   4560

agagctgata tcaaaccctc atttggtctg ttttatcaag cttggactgc agcagatgtg   4620

gaactagaga ttcgtcacag attccagtaa catttaggaa aatgtttggc tctgctattc   4680

cagttcagta gaacaacttc gaaactggat ttttctgtag ggtgtcatca tcaccctgag   4740

atgccaatgt catctgtgtt gttatagtct tgggtctgct ttgtgatcca atgagcccaa   4800

aagagtaaaa tgccctcaaa ggattgagaa aaaaaaaagg aaaaaacaaa acaaaggaaa   4860

acaaaacctt cccaattgag actttagcag cgttgtttag tgttctaaaa aaaaaagaaa   4920

ggcaatgaaa ctaatgagac ctgtaaagag aatatgagag agtagggaga gcagggtaga   4980

tggaagctat taaacattta ctatgtgtca gatgttttca tggtgtaata tcatttgtct   5040

tgtaaaagtc ctctgtggtg ggttttatca tttttattat tttatttcat gaaggactga   5100

actgaggctc agaggttaat aatgccccac aggtcatgta gtaaattgta gaggcaggat   5160

ccaaactgat atctttttgc ctccaatgct cgtgttcttt tctagtaact catgccacct   5220

tcccatagac aaggttattt tgttcccaag cttacttaac ttcctctgca tgtcgtaaaa   5280

tcctaaattc ctaaattctc cctgacccca agtgaaagat ccatttggat caacattttt   5340

gttacagtgt tgtttctact ctgtgtgctc tcttaagtcc tggagcaata tgagattaat   5400

tgttctaggt ataataaact catgcagtca aatactatca cttcagctca catatgtgag   5460

gcaacttgac cttgagttcg aattgaccaa ggccactcaa acctatttga actaaatggg   5520

tctggccagg tacccttcat actgacatta gttttagata gtctaagggt aacacatgct   5580

tgaacaaacg tgattttatt ttaaattgga aataaaataa catctagtca gatgactgct   5640

gtttcaggct ggaatgatgt ctgacatcaa tttctagcag ctggaatcca ttccccaagt   5700

ggcaaagcgt accttggcct ctataaccct gaagctcagc cagtttctta aggtcttcta   5760

atagaaaaca gcaagatatt tcttaagggt ggttcagaaa gcataatttg gagttgattc   5820

taatcctagc agtgacctat gttaggcaaa tgccttggat agtgctcagt cccctatgac   5880

ctt                                                                 5883


<210>  6836
<211>  1111
<212>  PRT
<213>  Homosapiens

<400>  6836

Met Pro Ala Leu Trp Leu Gly Cys Cys Leu Cys Phe Ser Leu Leu Leu 
1               5                   10                  15      


Pro Ala Ala Arg Ala Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly 
            20                  25                  30          


Lys Ser Arg Gln Cys Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly 
        35                  40                  45              


Asn Gly Phe Arg Cys Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His 
    50                  55                  60                  


Cys Glu Lys Cys Lys Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg 
65                  70                  75                  80  


Cys Leu Pro Cys Asn Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys 
                85                  90                  95      


Asp Asn Ser Gly Arg Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg 
            100                 105                 110         


Cys Asp Arg Cys Leu Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys 
        115                 120                 125             


Thr Gln Asp Gln Arg Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala 
    130                 135                 140                 


Gly Ile Ala Gly Pro Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala 
145                 150                 155                 160 


Val Thr Gly Glu Arg Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu 
                165                 170                 175     


Asp Gly Gly Asn Pro Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His 
            180                 185                 190         


Ser Ala Ser Cys Arg Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr 
        195                 200                 205             


Ser Thr Phe His Gln Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn 
    210                 215                 220                 


Gly Ser Pro Ala Lys Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe 
225                 230                 235                 240 


Ser Ser Ala Gln Arg Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys 
                245                 250                 255     


Phe Leu Gly Asn Gln Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp 
            260                 265                 270         


Tyr Arg Val Asp Arg Gly Gly Arg His Pro Ser Ala His Asp Val Ile 
        275                 280                 285             


Leu Glu Gly Ala Gly Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly 
    290                 295                 300                 


Lys Thr Leu Pro Cys Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn 
305                 310                 315                 320 


Glu His Pro Ser Asn Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr 
                325                 330                 335     


Arg Arg Leu Leu Arg Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr 
            340                 345                 350         


Gly Glu Tyr Ser Thr Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala 
        355                 360                 365             


Arg Pro Val Ser Gly Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys 
    370                 375                 380                 


Pro Val Gly Tyr Lys Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr 
385                 390                 395                 400 


Lys Arg Asp Ser Ala Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys 
                405                 410                 415     


Asn Cys Gln Gly Gly Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr 
            420                 425                 430         


Ser Gly Asp Glu Asn Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly 
        435                 440                 445             


Phe Tyr Asn Asp Pro His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys 
    450                 455                 460                 


His Asn Gly Phe Ser Cys Ser Val Met Pro Glu Thr Glu Glu Val Val 
465                 470                 475                 480 


Cys Asn Asn Cys Pro Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys 
                485                 490                 495     


Ala Asp Gly Tyr Phe Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg 
            500                 505                 510         


Pro Cys Gln Pro Cys Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser 
        515                 520                 525             


Gly Asn Cys Asp Arg Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn 
    530                 535                 540                 


Thr Ala Gly Ile Tyr Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp 
545                 550                 555                 560 


Pro Leu Ala Pro Asn Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn 
                565                 570                 575     


Pro Met Gly Ser Glu Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val 
            580                 585                 590         


Cys Lys Pro Gly Phe Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser 
        595                 600                 605             


Cys Pro Ala Cys Tyr Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met 
    610                 615                 620                 


Gln Gln Leu Gln Arg Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly 
625                 630                 635                 640 


Asp Gly Val Val Pro Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala 
                645                 650                 655     


Glu Gln Ala Leu Gln Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly 
            660                 665                 670         


Ala Ser Arg Ser Leu Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu 
        675                 680                 685             


Asn Ser Tyr Gln Ser Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg 
    690                 695                 700                 


Val Arg Ala Leu Gly Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His 
705                 710                 715                 720 


Arg Leu Ile Thr Gln Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser 
                725                 730                 735     


Leu Gly Asn Thr Asn Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn 
            740                 745                 750         


Gly Phe Lys Ser Leu Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His 
        755                 760                 765             


Val Glu Ser Ala Ser Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp 
    770                 775                 780                 


Tyr Ser Lys Gln Ala Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly 
785                 790                 795                 800 


Val Gly Ser Gly Ser Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu 
                805                 810                 815     


Val Glu Lys Leu Glu Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg 
            820                 825                 830         


Glu Ala Thr Gln Ala Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser 
        835                 840                 845             


Leu Arg Leu Leu Asp Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln 
    850                 855                 860                 


Ser Phe Gln Val Glu Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser 
865                 870                 875                 880 


Leu Ser Ser Leu Val Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln 
                885                 890                 895     


Lys Asn Leu Gly Asn Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn 
            900                 905                 910         


Gly Lys Ser Gly Arg Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn 
        915                 920                 925             


Leu Ala Lys Ser Arg Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr 
    930                 935                 940                 


Phe Tyr Glu Val Glu Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu 
945                 950                 955                 960 


Gln Val Asp Asn Arg Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu 
                965                 970                 975     


Ser Tyr Ile Ser Gln Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln 
            980                 985                 990         


Ala Glu Arg Ala Leu Gly Ser Ala  Ala Ala Asp Ala Gln  Arg Ala Lys 
        995                 1000                 1005             


Asn Gly  Ala Gly Glu Ala Leu  Glu Ile Ser Ser Glu  Ile Glu Gln 
    1010                 1015                 1020             


Glu Ile  Gly Ser Leu Asn Leu  Glu Ala Asn Val Thr  Ala Asp Gly 
    1025                 1030                 1035             


Ala Leu  Ala Met Glu Lys Gly  Leu Ala Ser Leu Lys  Ser Glu Met 
    1040                 1045                 1050             


Arg Glu  Val Glu Gly Glu Leu  Glu Arg Lys Glu Leu  Glu Phe Asp 
    1055                 1060                 1065             


Thr Asn  Met Asp Ala Val Gln  Met Val Ile Thr Glu  Ala Gln Lys 
    1070                 1075                 1080             


Val Asp  Thr Arg Ala Lys Asn  Ala Gly Val Thr Ile  Gln Asp Thr 
    1085                 1090                 1095             


Leu Asn  Thr Leu Asp Gly Leu  Leu His Leu Met Gly  Met 
    1100                 1105                 1110     


<210>  6837
<211>  5201
<212>  DNA
<213>  Homosapiens

<400>  6837
accacctgat caaggaaaag gaaggcacag cggagcgcag agtgagaacc accaaccgag     60

gcgccgggca gcgacccctg cagcggagac agagactgag cggcccggcc ccgccatgcc    120

tgcgctctgg ctgggctgct gcctctgctt ctcgctcctc ctgcccgcag cccgggccac    180

ctccaggagg gaagtctgtg attgcaatgg gaagtccagg cagtgtatct ttgatcggga    240

acttcacaga caaactggta atggattccg ctgcctcaac tgcaatgaca acactgatgg    300

cattcactgc gagaagtgca agaatggctt ttaccggcac agagaaaggg accgctgttt    360

gccctgcaat tgtaactcca aaggttctct tagtgctcga tgtgacaact ccggacggtg    420

cagctgtaaa ccaggtgtga caggagccag atgcgaccga tgtctgccag gcttccacat    480

gctcacggat gcggggtgca cccaagacca gagactgcta gactccaagt gtgactgtga    540

cccagctggc atcgcagggc cctgtgacgc gggccgctgt gtctgcaagc cagctgtcac    600

tggagaacgc tgtgataggt gtcgatcagg ttactataat ctggatgggg ggaaccctga    660

gggctgtacc cagtgtttct gctatgggca ttcagccagc tgccgcagct ctgcagaata    720

cagtgtccat aagatcacct ctacctttca tcaagatgtt gatggctgga aggctgtcca    780

acgaaatggg tctcctgcaa agctccaatg gtcacagcgc catcaagatg tgtttagctc    840

agcccaacga ctagaccctg tctattttgt ggctcctgcc aaatttcttg ggaatcaaca    900

ggtgagctat ggtcaaagcc tgtcctttga ctaccgtgtg gacagaggag gcagacaccc    960

atctgcccat gatgtgattc tggaaggtgc tggtctacgg atcacagctc ccttgatgcc   1020

acttggcaag acactgcctt gtgggctcac caagacttac acattcaggt taaatgagca   1080

tccaagcaat aattggagcc cccagctgag ttactttgag tatcgaaggt tactgcggaa   1140

tctcacagcc ctccgcatcc gagctacata tggagaatac agtactgggt acattgacaa   1200

tgtgaccctg atttcagccc gccctgtctc tggagcccca gcaccctggg ttgaacagtg   1260

tatatgtcct gttgggtaca aggggcaatt ctgccaggat tgtgcttctg gctacaagag   1320

agattcagcg agactggggc cttttggcac ctgtattcct tgtaactgtc aagggggagg   1380

ggcctgtgat ccagacacag gagattgtta ttcaggggat gagaatcctg acattgagtg   1440

tgctgactgc ccaattggtt tctacaacga tccgcacgac ccccgcagct gcaagccatg   1500

tccctgtcat aacgggttca gctgctcagt gatgccggag acggaggagg tggtgtgcaa   1560

taactgccct cccggggtca ccggtgcccg ctgtgagctc tgtgctgatg gctactttgg   1620

ggaccccttt ggtgaacatg gcccagtgag gccttgtcag ccctgtcaat gcaacaacaa   1680

tgtggacccc agtgcctctg ggaattgtga ccggctgaca ggcaggtgtt tgaagtgtat   1740

ccacaacaca gccggcatct actgcgacca gtgcaaagca ggctacttcg gggacccatt   1800

ggctcccaac ccagcagaca agtgtcgagc ttgcaactgt aaccccatgg gctcagagcc   1860

tgtaggatgt cgaagtgatg gcacctgtgt ttgcaagcca ggatttggtg gccccaactg   1920

tgagcatgga gcattcagct gtccagcttg ctataatcaa gtgaagattc agatggatca   1980

gtttatgcag cagcttcaga gaatggaggc cctgatttca aaggctcagg gtggtgatgg   2040

agtagtacct gatacagagc tggaaggcag gatgcagcag gctgagcagg cccttcagga   2100

cattctgaga gatgcccaga tttcagaagg tgctagcaga tcccttggtc tccagttggc   2160

caaggtgagg agccaagaga acagctacca gagccgcctg gatgacctca agatgactgt   2220

ggaaagagtt cgggctctgg gaagtcagta ccagaaccga gttcgggata ctcacaggct   2280

catcactcag atgcagctga gcctggcaga aagtgaagct tccttgggaa acactaacat   2340

tcctgcctca gaccactacg tggggccaaa tggctttaaa agtctggctc aggaggccac   2400

aagattagca gaaagccacg ttgagtcagc cagtaacatg gagcaactga caagggaaac   2460

tgaggactat tccaaacaag ccctctcact ggtgcgcaag gccctgcatg aaggagtcgg   2520

aagcggaagc ggtagcccgg acggtgctgt ggtgcaaggg cttgtggaaa aattggagaa   2580

aaccaagtcc ctggcccagc agttgacaag ggaggccact caagcggaaa ttgaagcaga   2640

taggtcttat cagcacagtc tccgcctcct ggattcagtg tctcggcttc agggagtcag   2700

tgatcagtcc tttcaggtgg aagaagcaaa gaggatcaaa caaaaagcgg attcactctc   2760

aagcctggta accaggcata tggatgagtt caagcgtaca cagaagaatc tgggaaactg   2820

gaaagaagaa gcacagcagc tcttacagaa tggaaaaagt gggagagaga aatcagatca   2880

gctgctttcc cgtgccaatc ttgctaaaag cagagcacaa gaagcactga gtatgggcaa   2940

tgccactttt tatgaagttg agagcatcct taaaaacctc agagagtttg acctgcaggt   3000

ggacaacaga aaagcagaag ctgaagaagc catgaagaga ctctcctaca tcagccagaa   3060

ggtttcagat gccagtgaca agacccagca agcagaaaga gccctgggga gcgctgctgc   3120

tgatgcacag agggcaaaga atggggccgg ggaggccctg gaaatctcca gtgagattga   3180

acaggagatt gggagtctga acttggaagc caatgtgaca gcagatggag ccttggccat   3240

ggaaaaggga ctggcctctc tgaagagtga gatgagggaa gtggaaggag agctggaaag   3300

gaaggagctg gagtttgaca cgaatatgga tgcagtacag atggtgatta cagaagccca   3360

gaaggttgat accagagcca agaacgctgg ggttacaatc caagacacac tcaacacatt   3420

agacggcctc ctgcatctga tggaccagcc tctcagtgta gatgaagagg ggctggtctt   3480

actggagcag aagctttccc gagccaagac ccagatcaac agccaactgc ggcccatgat   3540

gtcagagctg gaagagaggg cacgtcagca gaggggccac ctccatttgc tggagacaag   3600

catagatggg attctggctg atgtgaagaa cttggagaac attagggaca acctgccccc   3660

aggctgctac aatacccagg ctcttgagca acagtgaagc tgccataaat atttctcaac   3720

tgaggttctt gggatacaga tctcagggct cgggagccat gtcatgtgag tgggtgggat   3780

ggggacattt gaacatgttt aatgggtatg ctcaggtcaa ctgacctgac cccattcctg   3840

atcccatggc caggtggttg tcttattgca ccatactcct tgcttcctga tgctgggcaa   3900

tgaggcagat agcactgggt gtgagaatga tcaaggatct ggaccccaaa gaatagactg   3960

gatggaaaga caaactgcac aggcagatgt ttgcctcata atagtcgtaa gtggagtcct   4020

ggaatttgga caagtgctgt tgggatatag tcaacttatt ctttgagtaa tgtgactaaa   4080

ggaaaaaact ttgactttgc ccaggcatga aattcttcct aatgtcagaa cagagtgcaa   4140

cccagtcaca ctgtggccag taaaatacta ttgcctcata ttgtcctctg caagcttctt   4200

gctgatcaga gttcctccta cttacaaccc agggtgtgaa catgttctcc attttcaagc   4260

tggaagaagt gagcagtgtt ggagtgagga cctgtaaggc aggcccattc agagctatgg   4320

tgcttgctgg tgcctgccac cttcaagttc tggacctggg catgacatcc tttcttttaa   4380

tgatgccatg gcaacttaga gattgcattt ttattaaagc atttcctacc agcaaagcaa   4440

atgttgggaa agtatttact ttttcggttt caaagtgata gaaaagtgtg gcttgggcat   4500

tgaaagaggt aaaattctct agatttatta gtcctaattc aatcctactt ttcgaacacc   4560

aaaaatgatg cgcatcaatg tattttatct tattttctca atctcctctc tctttcctcc   4620

acccataata agagaatgtt cctactcaca cttcagctgg gtcacatcca tccctccatt   4680

catccttcca tccatctttc catccattac ctccatccat ccttccaaca tatatttatt   4740

gagtacctac tgtgtgccag gggctggtgg gacagtggtg acatagtctc tgccctcata   4800

gagttgattg tctagtgagg aagacaagca tttttaaaaa ataaatttaa acttacaaac   4860

tttgtttgtc acaagtggtg tttattgcaa taaccgcttg gtttgcaacc tctttgctca   4920

acagaacata tgttgcaaga ccctcccatg ggggcacttg agttttggca aggctgacag   4980

agctctgggt tgtgcacatt tctttgcatt ccagctgtca ctctgtgcct ttctacaact   5040

gattgcaaca gactgttgag ttatgataac accagtggga attgctggag gaaccagagg   5100

cacttccacc ttggctggga agactatggt gctgccttgc ttctgtattt ccttggattt   5160

tcctgaaagt gtttttaaat aaagaacaat tgttagatgc c                       5201


<210>  6838
<211>  1193
<212>  PRT
<213>  Homosapiens

<400>  6838

Met Pro Ala Leu Trp Leu Gly Cys Cys Leu Cys Phe Ser Leu Leu Leu 
1               5                   10                  15      


Pro Ala Ala Arg Ala Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly 
            20                  25                  30          


Lys Ser Arg Gln Cys Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly 
        35                  40                  45              


Asn Gly Phe Arg Cys Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His 
    50                  55                  60                  


Cys Glu Lys Cys Lys Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg 
65                  70                  75                  80  


Cys Leu Pro Cys Asn Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys 
                85                  90                  95      


Asp Asn Ser Gly Arg Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg 
            100                 105                 110         


Cys Asp Arg Cys Leu Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys 
        115                 120                 125             


Thr Gln Asp Gln Arg Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala 
    130                 135                 140                 


Gly Ile Ala Gly Pro Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala 
145                 150                 155                 160 


Val Thr Gly Glu Arg Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu 
                165                 170                 175     


Asp Gly Gly Asn Pro Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His 
            180                 185                 190         


Ser Ala Ser Cys Arg Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr 
        195                 200                 205             


Ser Thr Phe His Gln Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn 
    210                 215                 220                 


Gly Ser Pro Ala Lys Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe 
225                 230                 235                 240 


Ser Ser Ala Gln Arg Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys 
                245                 250                 255     


Phe Leu Gly Asn Gln Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp 
            260                 265                 270         


Tyr Arg Val Asp Arg Gly Gly Arg His Pro Ser Ala His Asp Val Ile 
        275                 280                 285             


Leu Glu Gly Ala Gly Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly 
    290                 295                 300                 


Lys Thr Leu Pro Cys Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn 
305                 310                 315                 320 


Glu His Pro Ser Asn Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr 
                325                 330                 335     


Arg Arg Leu Leu Arg Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr 
            340                 345                 350         


Gly Glu Tyr Ser Thr Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala 
        355                 360                 365             


Arg Pro Val Ser Gly Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys 
    370                 375                 380                 


Pro Val Gly Tyr Lys Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr 
385                 390                 395                 400 


Lys Arg Asp Ser Ala Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys 
                405                 410                 415     


Asn Cys Gln Gly Gly Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr 
            420                 425                 430         


Ser Gly Asp Glu Asn Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly 
        435                 440                 445             


Phe Tyr Asn Asp Pro His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys 
    450                 455                 460                 


His Asn Gly Phe Ser Cys Ser Val Met Pro Glu Thr Glu Glu Val Val 
465                 470                 475                 480 


Cys Asn Asn Cys Pro Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys 
                485                 490                 495     


Ala Asp Gly Tyr Phe Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg 
            500                 505                 510         


Pro Cys Gln Pro Cys Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser 
        515                 520                 525             


Gly Asn Cys Asp Arg Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn 
    530                 535                 540                 


Thr Ala Gly Ile Tyr Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp 
545                 550                 555                 560 


Pro Leu Ala Pro Asn Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn 
                565                 570                 575     


Pro Met Gly Ser Glu Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val 
            580                 585                 590         


Cys Lys Pro Gly Phe Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser 
        595                 600                 605             


Cys Pro Ala Cys Tyr Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met 
    610                 615                 620                 


Gln Gln Leu Gln Arg Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly 
625                 630                 635                 640 


Asp Gly Val Val Pro Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala 
                645                 650                 655     


Glu Gln Ala Leu Gln Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly 
            660                 665                 670         


Ala Ser Arg Ser Leu Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu 
        675                 680                 685             


Asn Ser Tyr Gln Ser Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg 
    690                 695                 700                 


Val Arg Ala Leu Gly Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His 
705                 710                 715                 720 


Arg Leu Ile Thr Gln Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser 
                725                 730                 735     


Leu Gly Asn Thr Asn Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn 
            740                 745                 750         


Gly Phe Lys Ser Leu Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His 
        755                 760                 765             


Val Glu Ser Ala Ser Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp 
    770                 775                 780                 


Tyr Ser Lys Gln Ala Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly 
785                 790                 795                 800 


Val Gly Ser Gly Ser Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu 
                805                 810                 815     


Val Glu Lys Leu Glu Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg 
            820                 825                 830         


Glu Ala Thr Gln Ala Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser 
        835                 840                 845             


Leu Arg Leu Leu Asp Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln 
    850                 855                 860                 


Ser Phe Gln Val Glu Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser 
865                 870                 875                 880 


Leu Ser Ser Leu Val Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln 
                885                 890                 895     


Lys Asn Leu Gly Asn Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn 
            900                 905                 910         


Gly Lys Ser Gly Arg Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn 
        915                 920                 925             


Leu Ala Lys Ser Arg Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr 
    930                 935                 940                 


Phe Tyr Glu Val Glu Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu 
945                 950                 955                 960 


Gln Val Asp Asn Arg Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu 
                965                 970                 975     


Ser Tyr Ile Ser Gln Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln 
            980                 985                 990         


Ala Glu Arg Ala Leu Gly Ser Ala  Ala Ala Asp Ala Gln  Arg Ala Lys 
        995                 1000                 1005             


Asn Gly  Ala Gly Glu Ala Leu  Glu Ile Ser Ser Glu  Ile Glu Gln 
    1010                 1015                 1020             


Glu Ile  Gly Ser Leu Asn Leu  Glu Ala Asn Val Thr  Ala Asp Gly 
    1025                 1030                 1035             


Ala Leu  Ala Met Glu Lys Gly  Leu Ala Ser Leu Lys  Ser Glu Met 
    1040                 1045                 1050             


Arg Glu  Val Glu Gly Glu Leu  Glu Arg Lys Glu Leu  Glu Phe Asp 
    1055                 1060                 1065             


Thr Asn  Met Asp Ala Val Gln  Met Val Ile Thr Glu  Ala Gln Lys 
    1070                 1075                 1080             


Val Asp  Thr Arg Ala Lys Asn  Ala Gly Val Thr Ile  Gln Asp Thr 
    1085                 1090                 1095             


Leu Asn  Thr Leu Asp Gly Leu  Leu His Leu Met Asp  Gln Pro Leu 
    1100                 1105                 1110             


Ser Val  Asp Glu Glu Gly Leu  Val Leu Leu Glu Gln  Lys Leu Ser 
    1115                 1120                 1125             


Arg Ala  Lys Thr Gln Ile Asn  Ser Gln Leu Arg Pro  Met Met Ser 
    1130                 1135                 1140             


Glu Leu  Glu Glu Arg Ala Arg  Gln Gln Arg Gly His  Leu His Leu 
    1145                 1150                 1155             


Leu Glu  Thr Ser Ile Asp Gly  Ile Leu Ala Asp Val  Lys Asn Leu 
    1160                 1165                 1170             


Glu Asn  Ile Arg Asp Asn Leu  Pro Pro Gly Cys Tyr  Asn Thr Gln 
    1175                 1180                 1185             


Ala Leu  Glu Gln Gln 
    1190             


<210>  6839
<211>  5656
<212>  DNA
<213>  Homosapiens

<400>  6839
acagcggagc gcagagtgag aaccaccaac cgaggcgccg ggcagcgacc cctgcagcgg     60

agacagagac tgagcggccc ggccccgcca tgcctgcgct ctggctgggc tgctgcctct    120

gcttctcgct cctcctgccc gcagcccggg ccacctccag gagggaagtc tgtgattgca    180

atgggaagtc caggcagtgt atctttgatc gggaacttca cagacaaact ggtaatggat    240

tccgctgcct caactgcaat gacaacactg atggcattca ctgcgagaag tgcaagaatg    300

gcttttaccg gcacagagaa agggaccgct gtttgccctg caattgtaac tccaaaggtt    360

ctcttagtgc tcgatgtgac aactccggac ggtgcagctg taaaccaggt gtgacaggag    420

ccagatgcga ccgatgtctg ccaggcttcc acatgctcac ggatgcgggg tgcacccaag    480

accagagact gctagactcc aagtgtgact gtgacccagc tggcatcgca gggccctgtg    540

acgcgggccg ctgtgtctgc aagccagctg tcactggaga acgctgtgat aggtgtcgat    600

caggttacta taatctggat ggggggaacc ctgagggctg tacccagtgt ttctgctatg    660

ggcattcagc cagctgccgc agctctgcag aatacagtgt ccataagatc acctctacct    720

ttcatcaaga tgttgatggc tggaaggctg tccaacgaaa tgggtctcct gcaaagctcc    780

aatggtcaca gcgccatcaa gatgtgttta gctcagccca acgactagac cctgtctatt    840

ttgtggctcc tgccaaattt cttgggaatc aacaggtgag ctatggtcaa agcctgtcct    900

ttgactaccg tgtggacaga ggaggcagac acccatctgc ccatgatgtg attctggaag    960

gtgctggtct acggatcaca gctcccttga tgccacttgg caagacactg ccttgtgggc   1020

tcaccaagac ttacacattc aggttaaatg agcatccaag caataattgg agcccccagc   1080

tgagttactt tgagtatcga aggttactgc ggaatctcac agccctccgc atccgagcta   1140

catatggaga atacagtact gggtacattg acaatgtgac cctgatttca gcccgccctg   1200

tctctggagc cccagcaccc tgggttgaac agtgtatatg tcctgttggg tacaaggggc   1260

aattctgcca ggattgtgct tctggctaca agagagattc agcgagactg gggccttttg   1320

gcacctgtat tccttgtaac tgtcaagggg gaggggcctg tgatccagac acaggagatt   1380

gttattcagg ggatgagaat cctgacattg agtgtgctga ctgcccaatt ggtttctaca   1440

acgatccgca cgacccccgc agctgcaagc catgtccctg tcataacggg ttcagctgct   1500

cagtgatgcc ggagacggag gaggtggtgt gcaataactg ccctcccggg gtcaccggtg   1560

cccgctgtga gctctgtgct gatggctact ttggggaccc ctttggtgaa catggcccag   1620

tgaggccttg tcagccctgt caatgcaaca acaatgtgga ccccagtgcc tctgggaatt   1680

gtgaccggct gacaggcagg tgtttgaagt gtatccacaa cacagccggc atctactgcg   1740

accagtgcaa agcaggctac ttcggggacc cattggctcc caacccagca gacaagtgtc   1800

gagcttgcaa ctgtaacccc atgggctcag agcctgtagg atgtcgaagt gatggcacct   1860

gtgtttgcaa gccaggattt ggtggcccca actgtgagca tggagcattc agctgtccag   1920

cttgctataa tcaagtgaag attcagatgg atcagtttat gcagcagctt cagagaatgg   1980

aggccctgat ttcaaaggct cagggtggtg atggagtagt acctgataca gagctggaag   2040

gcaggatgca gcaggctgag caggcccttc aggacattct gagagatgcc cagatttcag   2100

aaggtgctag cagatccctt ggtctccagt tggccaaggt gaggagccaa gagaacagct   2160

accagagccg cctggatgac ctcaagatga ctgtggaaag agttcgggct ctgggaagtc   2220

agtaccagaa ccgagttcgg gatactcaca ggctcatcac tcagatgcag ctgagcctgg   2280

cagaaagtga agcttccttg ggaaacacta acattcctgc ctcagaccac tacgtggggc   2340

caaatggctt taaaagtctg gctcaggagg ccacaagatt agcagaaagc cacgttgagt   2400

cagccagtaa catggagcaa ctgacaaggg aaactgagga ctattccaaa caagccctct   2460

cactggtgcg caaggccctg catgaaggag tcggaagcgg aagcggtagc ccggacggtg   2520

ctgtggtgca agggcttgtg gaaaaattgg agaaaaccaa gtccctggcc cagcagttga   2580

caagggaggc cactcaagcg gaaattgaag cagataggtc ttatcagcac agtctccgcc   2640

tcctggattc agtgtctcgg cttcagggag tcagtgatca gtcctttcag gtggaagaag   2700

caaagaggat caaacaaaaa gcggattcac tctcaagcct ggtaaccagg catatggatg   2760

agttcaagcg tacacagaag aatctgggaa actggaaaga agaagcacag cagctcttac   2820

agaatggaaa aagtgggaga gagaaatcag atcagctgct ttcccgtgcc aatcttgcta   2880

aaagcagagc acaagaagca ctgagtatgg gcaatgccac tttttatgaa gttgagagca   2940

tccttaaaaa cctcagagag tttgacctgc aggtggacaa cagaaaagca gaagctgaag   3000

aagccatgaa gagactctcc tacatcagcc agaaggtttc agatgccagt gacaagaccc   3060

agcaagcaga aagagccctg gggagcgctg ctgctgatgc acagagggca aagaatgggg   3120

ccggggaggc cctggaaatc tccagtgaga ttgaacagga gattgggagt ctgaacttgg   3180

aagccaatgt gacagcagat ggagccttgg ccatggaaaa gggactggcc tctctgaaga   3240

gtgagatgag ggaagtggaa ggagagctgg aaaggaagga gctggagttt gacacgaata   3300

tggatgcagt acagatggtg attacagaag cccagaaggt tgataccaga gccaagaacg   3360

ctggggttac aatccaagac acactcaaca cattagacgg cctcctgcat ctgatggacc   3420

agcctctcag tgtagatgaa gaggggctgg tcttactgga gcagaagctt tcccgagcca   3480

agacccagat caacagccaa ctgcggccca tgatgtcaga gctggaagag agggcacgtc   3540

agcagagggg ccacctccat ttgctggaga caagcataga tgggattctg gctgatgtga   3600

agaacttgga gaacattagg gacaacctgc ccccaggctg ctacaatacc caggctcttg   3660

agcaacagtg aagctgccat aaatatttct caactgaggt tcttgggata cagatctcag   3720

ggctcgggag ccatgtcatg tgagtgggtg ggatggggac atttgaacat gtttaatggg   3780

tatgctcagg tcaactgacc tgaccccatt cctgatccca tggccaggtg gttgtcttat   3840

tgcaccatac tccttgcttc ctgatgctgg gcaatgaggc agatagcact gggtgtgaga   3900

atgatcaagg atctggaccc caaagaatag actggatgga aagacaaact gcacaggcag   3960

atgtttgcct cataatagtc gtaagtggag tcctggaatt tggacaagtg ctgttgggat   4020

atagtcaact tattctttga gtaatgtgac taaaggaaaa aactttgact ttgcccaggc   4080

atgaaattct tcctaatgtc agaacagagt gcaacccagt cacactgtgg ccagtaaaat   4140

actattgcct catattgtcc tctgcaagct tcttgctgat cagagttcct cctacttaca   4200

acccagggtg tgaacatgtt ctccattttc aagctggaag aagtgagcag tgttggagtg   4260

aggacctgta aggcaggccc attcagagct atggtgcttg ctggtgcctg ccaccttcaa   4320

gttctggacc tgggcatgac atcctttctt ttaatgatgc catggcaact tagagattgc   4380

atttttatta aagcatttcc taccagcaaa gcaaatgttg ggaaagtatt tactttttcg   4440

gtttcaaagt gatagaaaag tgtggcttgg gcattgaaag aggtaaaatt ctctagattt   4500

attagtccta attcaatcct acttttcgaa caccaaaaat gatgcgcatc aatgtatttt   4560

atcttatttt ctcaatctcc tctctctttc ctccacccat aataagagaa tgttcctact   4620

cacacttcag ctgggtcaca tccatccctc cattcatcct tccatccatc tttccatcca   4680

ttacctccat ccatccttcc aacatatatt tattgagtac ctactgtgtg ccaggggctg   4740

gtgggacagt ggtgacatag tctctgccct catagagttg attgtctagt gaggaagaca   4800

agcattttta aaaaataaat ttaaacttac aaactttgtt tgtcacaagt ggtgtttatt   4860

gcaataaccg cttggtttgc aacctctttg ctcaacagaa catatgttgc aagaccctcc   4920

catgggggca cttgagtttt ggcaaggctg acagagctct gggttgtgca catttctttg   4980

cattccagct gtcactctgt gcctttctac aactgattgc aacagactgt tgagttatga   5040

taacaccagt gggaattgct ggaggaacca gaggcacttc caccttggct gggaagacta   5100

tggtgctgcc ttgcttctgt atttccttgg attttcctga aagtgttttt aaataaagaa   5160

caattgttag atgcctgggg tcagtttctg atttactaaa ctctaagcct atgatggtac   5220

caaagtaatg gaaatgaaaa tgccacagaa atggcaatag gtcctagagt tagcatcttc   5280

agttcccact tctgagcatc ttacttcgcc cattccaacc atacaggatt gatgatgctg   5340

tcaatgagat ttttatgagg tttaactgat gctgtcttct aagcataaag ctttatttct   5400

agaaaaactc tagctgggtg ggggggatat agttaatatt cttatctttt tcatcagcta   5460

taaaatgaag gtaaaattaa tagtttgtgg tgcatatgtc atgcttttta agaagttaaa   5520

atgtactaaa ttaagatctt gaattggtca tctacgcaag cggctgagga aacaattctg   5580

cttctgtcca ttgaccccca gattctgata ggtctggtca ctttgcttta ccttctgtga   5640

aaatgaattt gtaatc                                                   5656


<210>  6840
<211>  1193
<212>  PRT
<213>  Homosapiens

<400>  6840

Met Pro Ala Leu Trp Leu Gly Cys Cys Leu Cys Phe Ser Leu Leu Leu 
1               5                   10                  15      


Pro Ala Ala Arg Ala Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly 
            20                  25                  30          


Lys Ser Arg Gln Cys Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly 
        35                  40                  45              


Asn Gly Phe Arg Cys Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His 
    50                  55                  60                  


Cys Glu Lys Cys Lys Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg 
65                  70                  75                  80  


Cys Leu Pro Cys Asn Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys 
                85                  90                  95      


Asp Asn Ser Gly Arg Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg 
            100                 105                 110         


Cys Asp Arg Cys Leu Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys 
        115                 120                 125             


Thr Gln Asp Gln Arg Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala 
    130                 135                 140                 


Gly Ile Ala Gly Pro Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala 
145                 150                 155                 160 


Val Thr Gly Glu Arg Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu 
                165                 170                 175     


Asp Gly Gly Asn Pro Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His 
            180                 185                 190         


Ser Ala Ser Cys Arg Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr 
        195                 200                 205             


Ser Thr Phe His Gln Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn 
    210                 215                 220                 


Gly Ser Pro Ala Lys Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe 
225                 230                 235                 240 


Ser Ser Ala Gln Arg Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys 
                245                 250                 255     


Phe Leu Gly Asn Gln Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp 
            260                 265                 270         


Tyr Arg Val Asp Arg Gly Gly Arg His Pro Ser Ala His Asp Val Ile 
        275                 280                 285             


Leu Glu Gly Ala Gly Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly 
    290                 295                 300                 


Lys Thr Leu Pro Cys Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn 
305                 310                 315                 320 


Glu His Pro Ser Asn Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr 
                325                 330                 335     


Arg Arg Leu Leu Arg Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr 
            340                 345                 350         


Gly Glu Tyr Ser Thr Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala 
        355                 360                 365             


Arg Pro Val Ser Gly Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys 
    370                 375                 380                 


Pro Val Gly Tyr Lys Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr 
385                 390                 395                 400 


Lys Arg Asp Ser Ala Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys 
                405                 410                 415     


Asn Cys Gln Gly Gly Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr 
            420                 425                 430         


Ser Gly Asp Glu Asn Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly 
        435                 440                 445             


Phe Tyr Asn Asp Pro His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys 
    450                 455                 460                 


His Asn Gly Phe Ser Cys Ser Val Met Pro Glu Thr Glu Glu Val Val 
465                 470                 475                 480 


Cys Asn Asn Cys Pro Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys 
                485                 490                 495     


Ala Asp Gly Tyr Phe Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg 
            500                 505                 510         


Pro Cys Gln Pro Cys Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser 
        515                 520                 525             


Gly Asn Cys Asp Arg Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn 
    530                 535                 540                 


Thr Ala Gly Ile Tyr Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp 
545                 550                 555                 560 


Pro Leu Ala Pro Asn Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn 
                565                 570                 575     


Pro Met Gly Ser Glu Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val 
            580                 585                 590         


Cys Lys Pro Gly Phe Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser 
        595                 600                 605             


Cys Pro Ala Cys Tyr Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met 
    610                 615                 620                 


Gln Gln Leu Gln Arg Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly 
625                 630                 635                 640 


Asp Gly Val Val Pro Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala 
                645                 650                 655     


Glu Gln Ala Leu Gln Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly 
            660                 665                 670         


Ala Ser Arg Ser Leu Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu 
        675                 680                 685             


Asn Ser Tyr Gln Ser Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg 
    690                 695                 700                 


Val Arg Ala Leu Gly Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His 
705                 710                 715                 720 


Arg Leu Ile Thr Gln Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser 
                725                 730                 735     


Leu Gly Asn Thr Asn Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn 
            740                 745                 750         


Gly Phe Lys Ser Leu Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His 
        755                 760                 765             


Val Glu Ser Ala Ser Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp 
    770                 775                 780                 


Tyr Ser Lys Gln Ala Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly 
785                 790                 795                 800 


Val Gly Ser Gly Ser Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu 
                805                 810                 815     


Val Glu Lys Leu Glu Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg 
            820                 825                 830         


Glu Ala Thr Gln Ala Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser 
        835                 840                 845             


Leu Arg Leu Leu Asp Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln 
    850                 855                 860                 


Ser Phe Gln Val Glu Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser 
865                 870                 875                 880 


Leu Ser Ser Leu Val Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln 
                885                 890                 895     


Lys Asn Leu Gly Asn Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn 
            900                 905                 910         


Gly Lys Ser Gly Arg Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn 
        915                 920                 925             


Leu Ala Lys Ser Arg Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr 
    930                 935                 940                 


Phe Tyr Glu Val Glu Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu 
945                 950                 955                 960 


Gln Val Asp Asn Arg Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu 
                965                 970                 975     


Ser Tyr Ile Ser Gln Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln 
            980                 985                 990         


Ala Glu Arg Ala Leu Gly Ser Ala  Ala Ala Asp Ala Gln  Arg Ala Lys 
        995                 1000                 1005             


Asn Gly  Ala Gly Glu Ala Leu  Glu Ile Ser Ser Glu  Ile Glu Gln 
    1010                 1015                 1020             


Glu Ile  Gly Ser Leu Asn Leu  Glu Ala Asn Val Thr  Ala Asp Gly 
    1025                 1030                 1035             


Ala Leu  Ala Met Glu Lys Gly  Leu Ala Ser Leu Lys  Ser Glu Met 
    1040                 1045                 1050             


Arg Glu  Val Glu Gly Glu Leu  Glu Arg Lys Glu Leu  Glu Phe Asp 
    1055                 1060                 1065             


Thr Asn  Met Asp Ala Val Gln  Met Val Ile Thr Glu  Ala Gln Lys 
    1070                 1075                 1080             


Val Asp  Thr Arg Ala Lys Asn  Ala Gly Val Thr Ile  Gln Asp Thr 
    1085                 1090                 1095             


Leu Asn  Thr Leu Asp Gly Leu  Leu His Leu Met Asp  Gln Pro Leu 
    1100                 1105                 1110             


Ser Val  Asp Glu Glu Gly Leu  Val Leu Leu Glu Gln  Lys Leu Ser 
    1115                 1120                 1125             


Arg Ala  Lys Thr Gln Ile Asn  Ser Gln Leu Arg Pro  Met Met Ser 
    1130                 1135                 1140             


Glu Leu  Glu Glu Arg Ala Arg  Gln Gln Arg Gly His  Leu His Leu 
    1145                 1150                 1155             


Leu Glu  Thr Ser Ile Asp Gly  Ile Leu Ala Asp Val  Lys Asn Leu 
    1160                 1165                 1170             


Glu Asn  Ile Arg Asp Asn Leu  Pro Pro Gly Cys Tyr  Asn Thr Gln 
    1175                 1180                 1185             


Ala Leu  Glu Gln Gln 
    1190             


<210>  6841
<211>  848
<212>  DNA
<213>  Homosapiens

<400>  6841
gatctctttt gaaatatact gttagtacaa tcgatggttg gcatcacaaa ttgaagatta     60

cggcagatga aatacccata cgccttaagt gttataaatt ccaaccacaa agagtttctg    120

aaaggaattg ctactactaa catactctgc aagaaatcct gacttcagga ttattattgt    180

tgcagatgta attaaaatga ggttataata aattagagta agcccttaac tcaaaacaat    240

tggtgccatt ataagaggat gaccatgtga agacacagac acacagaaaa aacaccatgt    300

ggtgactgaa gcagagattg gtgtaatgca actacaagtc aacaagcaac tatgattgac    360

ggccaccacc aaggctagga agaggagaga aaaatatata tatctcaaga aagaaaaaat    420

ccagcaccta cggcataatg taaggagaga atgctccagc aaaatctaac ttgcacaata    480

aatctgttct gtcagatcct tgaccggtat gtttatgttg acctctttcc gtttgaagag    540

agaggaaaga aactggtgtt gatcaaaggt tacagcagaa taaaaaatat actgggacac    600

gaaattgtga catgtatttc ccccaccagt caggactcta tgttcaatat ttttatttca    660

ttatgcttac aaaagcaaat gaatgtccct ttgtatttcc ttaagaatga aaagatgaat    720

gtttctttct ttgcaagttc catggaagct aagaacctta atactataaa cattttaatg    780

cttgataatg gttctgtctt caaaatgcaa aacgttttat tctgacaaat aaaaactcta    840

aaaaaatg                                                             848


<210>  6842
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  6842

Met Leu Gln Gln Asn Leu Thr Cys Thr Ile Asn Leu Phe Cys Gln Ile 
1               5                   10                  15      


Leu Asp Arg Tyr Val Tyr Val Asp Leu Phe Pro Phe Glu Glu Arg Gly 
            20                  25                  30          


Lys Lys Leu Val Leu Ile Lys Gly Tyr Ser Arg Ile Lys Asn Ile Leu 
        35                  40                  45              


Gly His Glu Ile Val Thr Cys Ile Ser Pro Thr Ser Gln Asp Ser Met 
    50                  55                  60                  


Phe Asn Ile Phe Ile Ser Leu Cys Leu Gln Lys Gln Met Asn Val Pro 
65                  70                  75                  80  


Leu Tyr Phe Leu Lys Asn Glu Lys Met Asn Val Ser Phe Phe Ala Ser 
                85                  90                  95      


Ser Met Glu Ala Lys Asn Leu Asn Thr Ile Asn Ile Leu Met Leu Asp 
            100                 105                 110         


Asn Gly Ser Val Phe Lys Met Gln Asn Val Leu Phe 
        115                 120                 


<210>  6843
<211>  815
<212>  DNA
<213>  Homosapiens

<400>  6843
agaatgaagt gtcaatgaac catgatatac tggagccaaa gcagaattta tttcatccgg     60

ataaatctaa gggctgtcgt ctgtatctta attgtgagtc aagtgaaggc cactggctct    120

cttcagactc acagttaaca gtattgttgc agatgtaatt aaaatgaggt tataataaat    180

tagagtaagc ccttaactca aaacaattgg tgccattata agaggatgac catgtgaaga    240

cacagacaca cagaaaaaac accatgtggt gactgaagca gagattggtg taatgcaact    300

acaagtcaac aagcaactat gattgacggc caccaccaag gctaggaaga ggagagaaaa    360

atatatatat ctcaagaaag aaaaaatcca gcacctacgg cataatgtaa ggagagaatg    420

ctccagcaaa atctaacttg cacaataaat ctgttctgtc agatccttga ccggtatgtt    480

tatgttgacc tctttccgtt tgaagagaga ggaaagaaac tggtgttgat caaaggttac    540

agcagaataa aaaatatact gggacacgaa attgtgacat gtatttcccc caccagtcag    600

gactctatgt tcaatatttt tatttcatta tgcttacaaa agcaaatgaa tgtccctttg    660

tatttcctta agaatgaaaa gatgaatgtt tctttctttg caagttccat ggaagctaag    720

aaccttaata ctataaacat tttaatgctt gataatggtt ctgtcttcaa aatgcaaaac    780

gttttattct gacaaataaa aactctaaaa aaatg                               815


<210>  6844
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  6844

Met Asn His Asp Ile Leu Glu Pro Lys Gln Asn Leu Phe His Pro Asp 
1               5                   10                  15      


Lys Ser Lys Gly Cys Arg Leu Tyr Leu Asn Cys Glu Ser Ser Glu Gly 
            20                  25                  30          


His Trp Leu Ser Ser Asp Ser Gln Leu Thr Val Leu Leu Gln Met 
        35                  40                  45          


<210>  6845
<211>  830
<212>  DNA
<213>  Homosapiens

<400>  6845
aataaaattt ctgtttgtaa tcaacctaat ataaattcaa cacacaatta agatttagga     60

atgtgtaaca ccccaaggct cttaattttc aaaagtcaca aaactatgtt tactcaaatg    120

gtttgacatt atttaaaaat tggattctat cttattctct tgaggaaatt tttgggtagt    180

tagaagtttt gacataatta atttctgaat atttcacatt tatctttcag attttcctga    240

catcaatgta tccttttgag tatattatcg tatctcttaa catttctgtt tcatccttga    300

cctgagactt tttttttttt ttttaatctt gagataattc ttggctttgt caaggctact    360

ggtgacaaaa gcattagcaa gcaggtgcag agtgcttttt ccaccaaaga agagacattg    420

tactcttttt ggggttatat taatgactaa ttcacctctc tgtcctcctc aatgccatct    480

gtcttttgtt tggtctccct gatgttagtc acgaagtctg cttagaagga tttatgtctt    540

actttgatat aggttctata ctcaatgcta gggaacaatc attggcaaga tgtgtctcct    600

ttactcaaag aggttttaat ggtctatgtt tggaaaagag acatacagtc attagaatgc    660

aatattgtga aagttgacaa gggaaattct tggggttatg ggaatcttca atatctttat    720

tgagaaatac agatatacac atttatcaaa actcataaaa tgatgaattt gtagtatttt    780

attgtgtata aattatgcct caataaaagt tcattgtaat gtgctgaaag               830


<210>  6846
<211>  52
<212>  PRT
<213>  Homosapiens

<400>  6846

Met Leu Gly Asn Asn His Trp Gln Asp Val Ser Pro Leu Leu Lys Glu 
1               5                   10                  15      


Val Leu Met Val Tyr Val Trp Lys Arg Asp Ile Gln Ser Leu Glu Cys 
            20                  25                  30          


Asn Ile Val Lys Val Asp Lys Gly Asn Ser Trp Gly Tyr Gly Asn Leu 
        35                  40                  45              


Gln Tyr Leu Tyr 
    50          


<210>  6847
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  6847
ggagccgcgg ggcttccatc cttcctttga ctgattttta aattttaatt tgtattttcc     60

ccgccgcccc gccccttttc ctccgacccc gccctatcgc tccccggctt ccctgctctt    120

tcctttttcc cggcttcctt cctcgcgttt ctttcccctg cgccctcggc ttgcctctct    180

ccctcctccc tcgctctctc ccccttctct ccccttcttc ctcggtttct tccgtcctct    240

ctctccccct cctcctcccc cgcctcctcc tcctgcgctc ccgccccctg ccccctcccc    300

ccgtgcctgc agacgcgcgg atcgtccatg cgctcctcgc gggcagaatg ctgggcagca    360

gcgtcaagag cgtgcagccc gaggtggagc tgagcagcgg cggcggcgac gagggcgcgg    420

acgaaccgcg gggcgccggc aggaaggcgg cagcggcgga cggcagaggc atgctgccca    480

agcgcgccaa ggcgcccggc ggcggcggcg gcatggccaa ggccagcgcg gctgagctga    540

aggtcttcaa gtccggcagc gtggacagcc gtgtccccgg cgggccgccc gcctccaacc    600

tgcgcaagca gaagtcactc accaacctct cttttctcac ggactccgag aaaaagctgc    660

agctttatga gcccgaatgg agcgacgata tggccaaggc gcccaaaggc ttaggcaagg    720

tggggtccaa gggccgtgaa gctccgctga tgtccaagac gctgtccaag tcggagcact    780

cgctcttcca ggccaagggc agcccggcgg gcggcgccaa gacccccctg gctccgctcg    840

cgcccaacct gggaaagccg agccggatcc ctcgaggacc ctatgcggag gtcaagccgc    900

tcagcaaggc gcctgaagcg gccgtgagcg aagatggcaa atcggacgac gagctgctct    960

ccagcaaggc caaggcgcaa aagagctctg ggcctgtccc ctctgccaag ggccaggagg   1020

agcgcgcctt cctcaaggtg gaccccgagc tggtggtgac cgtgctggga gacctggagc   1080

agctgctctt cagccagatg ctggacccag agtcccagag aaagaggaca gtgcagaatg   1140

tcctggatct ccggcagaac ctggaagaga ccatgtccag cctgcgaggg tcccaggtga   1200

ctcacagctc cctggagatg acctgctacg acagcgatga tgccaaccca cgcagcgtgt   1260

ccagcctctc caaccgctcg tcccctctgt catggcgcta tggccagtcc agtccgcggc   1320

tgcaggctgg tgacgcgccc tctgtgggtg ggagctgccg ctcggagggg acgcccgcct   1380

ggtacatgca cggcgaacgg gcccactact cccacaccat gcccatgcgc agccccagca   1440

agctcagcca tatctcccgc ctggagctgg tcgaatccct ggactcggat gaggtggacc   1500

tcaagtccgg ctacatgagc gacagtgacc tcatgggcaa gaccatgacg gaggatgatg   1560

acatcactac cggctgggat gaaagcagct ccatcagtag tggactcagc gatgcctcag   1620

acaatctcag ttcagaagaa ttcaatgcca gctcctcact caactccctc ccaagtactc   1680

ccactgcttc tcgcaggaac tcaacaatag tgctacgcac agactcagag aagcgctcac   1740

tggcagaaag tgggctgagc tggtttagtg aatcagagga gaaagcccct aaaaaactgg   1800

agtacgacag tggtagcctg aagatggaac ctgggacttc taagtggcgg agggagcggc   1860

ctgagagctg tgatgattca tccaagggtg gagaactgaa aaagcccatc agcctgggcc   1920

accctggttc cctgaagaag ggcaagaccc cacctgtggc tgtaacttcc cccatcactc   1980

acacagccca gagtgccctc aaagtcgcag gcaaacctga gggcaaagct acagacaagg   2040

gtaagcttgc agtgaagaat actgggctcc aacgctcctc ctctgatgct ggtcgggacc   2100

gcctgagtga tgctaagaag cccccctcgg gcattgctcg cccctccact tcgggatcct   2160

ttggctacaa gaagcctcct cctgccacag gcacagccac tgtcatgcaa actggtggtt   2220

cagccactct cagcaagatc cagaagtcct caggcatccc tgtcaagcca gtaaatgggc   2280

gcaagactag cttagatgtt tccaacagtg cagagccagg attcctggct cctggagccc   2340

gttctaacat ccagtaccgc agcctgcccc ggccagccaa gtcaagttct atgagcgtga   2400

ccggcgggcg gggtggacct cgccctgtga gcagcagcat tgaccccagt ctcctcagca   2460

ccaagcaggg aggccttacg ccttccagac tgaaggagcc taccaaggta gccagtgggc   2520

ggaccactcc agcccctgtc aatcagacag atcgggaaaa ggagaaggcc aaagccaagg   2580

cagtggcctt ggactcagac aacatctcct tgaagagtat tggctcccca gaaagtactc   2640

ccaagaacca agcaagccac cccacagcca ccaagctggc agagctgcca ccaacccctc   2700

tcagggccac agcgaagagc tttgtcaaac caccctcact agccaatctt gacaaggtca   2760

actccaacag tctggatcta ccatcatcca gtgataccac ccatgcttca aaggtcccag   2820

atctgcatgc tacaagctca gcatctgggg gccctctccc ttcctgcttc acccccagtc   2880

cggcacccat cctcaatatt aactcagcca gcttctccca gggcctggag ctaatgagtg   2940

gtttcagtgt gccaaaagag acccgcatgt accccaaact ctcaggcctg cacaggagca   3000

tggagtccct ccagatgcca atgagcctcc ccagtgcctt ccccagcagt actcccgtcc   3060

ccaccccacc tgctccccct gctgctccca cagaagaaga gacggaagag ctgacttgga   3120

gtggaagccc cagagctggg caactggaca gtaatcagcg ggatcggaac actcttccca   3180

agaaagggct caggtaccag cttcagtccc aggaggagac caaggagagg cgacattccc   3240

ataccattgg tgggctgcct gaatccgatg accagtcaga gctgccttct ccccctgcac   3300

ttcccatgtc tctgagtgca aagggccaac ttaccaacat agtgagtccc actgcggcca   3360

ccacgccaag aatcacccgc tccaacagca tccccaccca cgaggcggcc ttcgagctgt   3420

acagcggctc ccaaatgggg agcaccctgt ccctggccga gagacccaag ggaatgattc   3480

ggtcaggatc cttccgagac cccacggacg atgttcacgg ctcagtgctg tccctggcct   3540

ccagtgcctc ctccacctac tcctcagctg aggagaggat gcaatctgag caaatccgga   3600

agcttcgtag ggaactggaa tcatcccagg aaaaagtggc caccttgacg tctcagcttt   3660

ctgccaatgc taatctggtg gctgcttttg agcagagcct ggtgaatatg acatcccgcc   3720

tgcgacacct ggcagagacg gccgaggaga aggacactga gctgctggat ttgcgagaaa   3780

ccatagactt tctgaagaaa aagaactctg aggcccaggc agtcattcag ggagccctta   3840

atgcctcaga aaccacaccc aaagaacttc ggatcaagag acaaaactcc tcagatagca   3900

tctcaagcct caacagcatc actagccatt ccagcatcgg cagcagcaag gatgctgatg   3960

cgaaaaagaa gaaaaaaaag agttggcttc gaagttcctt caacaaagcg ttcagtataa   4020

aaaaggggcc caagtcagct tcctcatact cggatataga ggagattgct acacccgact   4080

cttcagcccc ctcatccccc aaactacagc atggttctac agagactgct tcaccctcca   4140

tcaagtcctc cacctcgtcc tccgtgggca ctgatgtcac cgagggccct gctcacccag   4200

ccccccacac taggctgttc catgcaaatg aggaggagga gccagagaag aaggaggtat   4260

cggagctgcg ctctgagcta tgggagaagg aaatgaagct tacagacatc cgcttggagg   4320

ccctcaactc tgcccaccaa ctggatcagc ttcgggagac catgcacaac atgcagttgg   4380

aggtggacct gctgaaagca gagaatgacc gactgaaggt agccccaggc ccctcatcag   4440

gctccactcc agggcaggtc cctggatcat ctgcattatc ttccccacgc cgctccctag   4500

gcctggcact cacccattcc ttcggcccca gtcttgcaga cacagacctg tcacccatgg   4560

atggcatcag tacttgtggt ccaaaggagg aagtgaccct ccgggtggtg gtgaggatgc   4620

ccccgcagca catcatcaaa ggggacttga agcagcagga attcttcctg ggctgtagca   4680

aggtcagtgg aaaagttgac tggaagatgc tggatgaagc tgttttccaa gtgttcaagg   4740

actatatttc taaaatggac ccagcctcta ccctgggact aagcactgag tccatccatg   4800

gctacagcat cagccacgtg aaacgagtgt tggatgcaga gccccccgag atgcctcctt   4860

gccgtcgagg tgtcaataac atatcagtct ccctcaaagg tctgaaggag aaatgcgtcg   4920

acagcctggt gttcgagacg ctgatcccca agccgatgat gcagcactac ataagcctcc   4980

tgctgaagca ccggcgcctc gtcctctcgg gccccagcgg cacgggcaag acctacctga   5040

ccaatcgctt ggccgagtac ctggtggagc gctctggccg tgaggtcaca gagggcatcg   5100

tcagcacctt caacatgcac cagcagtctt gcaaggatct gcaactgtat ctttccaacc   5160

tagccaacca gatagaccgg gaaacaggaa ttggggatgt gcccctggtg attctattgg   5220

atgacctgag tgaagcaggc tccatcagtg agttggtcaa tggggccctc acctgcaagt   5280

atcataaatg tccctatatt ataggtacca ccaatcagcc tgtaaaaatg acacccaacc   5340

atggcttgca cttgagcttc aggatgttga ccttctccaa caacgtggag ccagccaatg   5400

gcttcctggt tcgttacctg aggaggaagc tggtagagtc agacagcgac atcaatgcca   5460

acaaggaaga gctgcttcgg gtgctcgact gggtacccaa gctgtggtat catctccaca   5520

ccttccttga gaagcacagc acctcagact tcctcatcgg cccttgcttc tttctgtcgt   5580

gtcccattgg cattgaggac ttccggacct ggttcattga cctgtggaac aactctatca   5640

ttccctatct acaggaagga gccaaggatg ggataaaggt ccatggacag aaagctgctt   5700

gggaggaccc agtggaatgg gtccgggaca cacttccctg gccatcagcc caacaagacc   5760

aatcaaagct gtaccacctg cccccaccca ccgtgggccc tcacagcatt gcctcacctc   5820

ccgaggatag gacagtcaaa gacagcaccc caagttctct ggactcagat cctctgatgg   5880

ccatgctgct gaaacttcaa gaagctgcca actacattga gtctccagat cgagaaacca   5940

tcctggaccc caaccttcag gcaacacttt aagggttcgg caatcactgt cacccccgga   6000

cagcagaacg ctggcatcag ctatcttagc tcctcctctc ccctctcctc tttcagagca   6060

ctggctctcc agccccagga ggagaacagg agggaggagg agatgaaaga ggagggacag   6120

gttcttggtg ctgtaccttt gagaacttcc taggaaggaa tggtggggtg gcgtttggga   6180

acttgtgccc cctaaacaca tttactggcc tcctctaatg actttgggga aaagatgatt   6240

ctgggtcttt cccttgactt cttgtttcaa ttacaaactc ctgggctttc tggggagggg   6300

ttcagaaaac atcaaaacac tgcagcagtt cctaaatgat tctcacaagc aaccctgaga   6360

gagacagtct tgtgagggag atctggggga ggcaggaagc tcctcagatt ttctcacaga   6420

cccttcccaa ttccatcacc actgccaaca actcctcccc cagagatctg gctggagccc   6480

agaaaaagaa gcatgtggtt taaaaaatgt ttaaatcaat ctgtaaaagg taaaaatgaa   6540

aaacaaaaac aagcaaacaa acaaaaaaca atggaaaaga tgaagctgga gagagaggaa   6600

ccagttgcca aggtagagag ctgcccgctc ctgccctctg gatgacatag gggacatcaa   6660

caagacggct gccaacctga gaagtcacca aaccacaaaa ataaccttac agccttcagg   6720

gaaagactac cagctctgtc tttctaccct ctaatttaac aatgcataag agtcaataaa   6780

ccctactttt ttatttttgg tttttatttt gttttcattt ttttctccca tttgcctatt   6840

tatttttttg tttccctttt ttttttcttt ttccgttttt ccatttcctc acatgtccac   6900

gagatgcttg ggttgctttt ccaggggcta gtttggcttt tccaagtggg ttttctttgg   6960

agaatctgat gccatgcaat tggcatgaca cctgccatgc cactatcttt ggcatccatg   7020

gggcttatat gagacatgaa gcattggctc agaagtagag ggagaagagg aacccagttc   7080

ccttgacttc ccttttgaga gcacacgttc tgctgggtag ctcaattgcc agcctctgtc   7140

atgagaaggt atagccccat cttgatagaa gagttactcc gagctttatc atggaccaga   7200

ggaaaaccag aaaactgaaa acattcctct gtcttgtggc cagtttggcc tttcactgca   7260

ctattctgat ggtgcctgac tgaatccaaa tatcctagct ggctcttact atttttcaca   7320

aatgagtatt cacatataag agatgaacat ccatgtgaga tcatcccaat cagaatataa   7380

gactcaagga gtttgacttg gtggccaata cctgccttcc aaagagatcc tacctttgca   7440

gatttgctcc tttcccattg ccttgaaggt ctggcaatcc ctgttctttc atttgacaag   7500

tacttactga gtactcacta tatacaaatc attaggttaa aacagacaca cacacacaca   7560

cacacacaca cacacacaca cacacacaca caagacctgg gcccttaagt ttacagtcca   7620

gcaggaaatg ttaacctcca ttcagctacg cccccttgtt atctagacct tcgggatcat   7680

ctaagaaatg tagctgaaac ccaaggagcc agctagaaag aagcttttga ttagatgtac   7740

aatacattgg gggcagaaga tctgggatca attaagatgg agcctgaagg actatggaat   7800

cttgcttgtc aggaatgggc aagtctactt cctgccattt ctgaaagccc cgcgggacca   7860

gcttctaggc tgagctgcct agtaggctga agcttcagga ctctgcaggt caaggatatg   7920

tgatgagcac cggcctaagt gtttgctctt cagattccta agtagcacaa gactttatca   7980

gaatctatag gcataccaac ctggatcact cttccaccca accgaggagt agatgcatct   8040

gaatcttcat atcggtatat taagtccaaa agatggtccg ggctgcccct cacaaaagct   8100

tctgcatcca cgtggtaagc tcccatggat gacagggttc tgtatgatgg agactattat   8160

tgctattgct gctaattcca tgagctgtga ag                                 8192


<210>  6848
<211>  1874
<212>  PRT
<213>  Homosapiens

<400>  6848

Met Leu Gly Ser Ser Val Lys Ser Val Gln Pro Glu Val Glu Leu Ser 
1               5                   10                  15      


Ser Gly Gly Gly Asp Glu Gly Ala Asp Glu Pro Arg Gly Ala Gly Arg 
            20                  25                  30          


Lys Ala Ala Ala Ala Asp Gly Arg Gly Met Leu Pro Lys Arg Ala Lys 
        35                  40                  45              


Ala Pro Gly Gly Gly Gly Gly Met Ala Lys Ala Ser Ala Ala Glu Leu 
    50                  55                  60                  


Lys Val Phe Lys Ser Gly Ser Val Asp Ser Arg Val Pro Gly Gly Pro 
65                  70                  75                  80  


Pro Ala Ser Asn Leu Arg Lys Gln Lys Ser Leu Thr Asn Leu Ser Phe 
                85                  90                  95      


Leu Thr Asp Ser Glu Lys Lys Leu Gln Leu Tyr Glu Pro Glu Trp Ser 
            100                 105                 110         


Asp Asp Met Ala Lys Ala Pro Lys Gly Leu Gly Lys Val Gly Ser Lys 
        115                 120                 125             


Gly Arg Glu Ala Pro Leu Met Ser Lys Thr Leu Ser Lys Ser Glu His 
    130                 135                 140                 


Ser Leu Phe Gln Ala Lys Gly Ser Pro Ala Gly Gly Ala Lys Thr Pro 
145                 150                 155                 160 


Leu Ala Pro Leu Ala Pro Asn Leu Gly Lys Pro Ser Arg Ile Pro Arg 
                165                 170                 175     


Gly Pro Tyr Ala Glu Val Lys Pro Leu Ser Lys Ala Pro Glu Ala Ala 
            180                 185                 190         


Val Ser Glu Asp Gly Lys Ser Asp Asp Glu Leu Leu Ser Ser Lys Ala 
        195                 200                 205             


Lys Ala Gln Lys Ser Ser Gly Pro Val Pro Ser Ala Lys Gly Gln Glu 
    210                 215                 220                 


Glu Arg Ala Phe Leu Lys Val Asp Pro Glu Leu Val Val Thr Val Leu 
225                 230                 235                 240 


Gly Asp Leu Glu Gln Leu Leu Phe Ser Gln Met Leu Asp Pro Glu Ser 
                245                 250                 255     


Gln Arg Lys Arg Thr Val Gln Asn Val Leu Asp Leu Arg Gln Asn Leu 
            260                 265                 270         


Glu Glu Thr Met Ser Ser Leu Arg Gly Ser Gln Val Thr His Ser Ser 
        275                 280                 285             


Leu Glu Met Thr Cys Tyr Asp Ser Asp Asp Ala Asn Pro Arg Ser Val 
    290                 295                 300                 


Ser Ser Leu Ser Asn Arg Ser Ser Pro Leu Ser Trp Arg Tyr Gly Gln 
305                 310                 315                 320 


Ser Ser Pro Arg Leu Gln Ala Gly Asp Ala Pro Ser Val Gly Gly Ser 
                325                 330                 335     


Cys Arg Ser Glu Gly Thr Pro Ala Trp Tyr Met His Gly Glu Arg Ala 
            340                 345                 350         


His Tyr Ser His Thr Met Pro Met Arg Ser Pro Ser Lys Leu Ser His 
        355                 360                 365             


Ile Ser Arg Leu Glu Leu Val Glu Ser Leu Asp Ser Asp Glu Val Asp 
    370                 375                 380                 


Leu Lys Ser Gly Tyr Met Ser Asp Ser Asp Leu Met Gly Lys Thr Met 
385                 390                 395                 400 


Thr Glu Asp Asp Asp Ile Thr Thr Gly Trp Asp Glu Ser Ser Ser Ile 
                405                 410                 415     


Ser Ser Gly Leu Ser Asp Ala Ser Asp Asn Leu Ser Ser Glu Glu Phe 
            420                 425                 430         


Asn Ala Ser Ser Ser Leu Asn Ser Leu Pro Ser Thr Pro Thr Ala Ser 
        435                 440                 445             


Arg Arg Asn Ser Thr Ile Val Leu Arg Thr Asp Ser Glu Lys Arg Ser 
    450                 455                 460                 


Leu Ala Glu Ser Gly Leu Ser Trp Phe Ser Glu Ser Glu Glu Lys Ala 
465                 470                 475                 480 


Pro Lys Lys Leu Glu Tyr Asp Ser Gly Ser Leu Lys Met Glu Pro Gly 
                485                 490                 495     


Thr Ser Lys Trp Arg Arg Glu Arg Pro Glu Ser Cys Asp Asp Ser Ser 
            500                 505                 510         


Lys Gly Gly Glu Leu Lys Lys Pro Ile Ser Leu Gly His Pro Gly Ser 
        515                 520                 525             


Leu Lys Lys Gly Lys Thr Pro Pro Val Ala Val Thr Ser Pro Ile Thr 
    530                 535                 540                 


His Thr Ala Gln Ser Ala Leu Lys Val Ala Gly Lys Pro Glu Gly Lys 
545                 550                 555                 560 


Ala Thr Asp Lys Gly Lys Leu Ala Val Lys Asn Thr Gly Leu Gln Arg 
                565                 570                 575     


Ser Ser Ser Asp Ala Gly Arg Asp Arg Leu Ser Asp Ala Lys Lys Pro 
            580                 585                 590         


Pro Ser Gly Ile Ala Arg Pro Ser Thr Ser Gly Ser Phe Gly Tyr Lys 
        595                 600                 605             


Lys Pro Pro Pro Ala Thr Gly Thr Ala Thr Val Met Gln Thr Gly Gly 
    610                 615                 620                 


Ser Ala Thr Leu Ser Lys Ile Gln Lys Ser Ser Gly Ile Pro Val Lys 
625                 630                 635                 640 


Pro Val Asn Gly Arg Lys Thr Ser Leu Asp Val Ser Asn Ser Ala Glu 
                645                 650                 655     


Pro Gly Phe Leu Ala Pro Gly Ala Arg Ser Asn Ile Gln Tyr Arg Ser 
            660                 665                 670         


Leu Pro Arg Pro Ala Lys Ser Ser Ser Met Ser Val Thr Gly Gly Arg 
        675                 680                 685             


Gly Gly Pro Arg Pro Val Ser Ser Ser Ile Asp Pro Ser Leu Leu Ser 
    690                 695                 700                 


Thr Lys Gln Gly Gly Leu Thr Pro Ser Arg Leu Lys Glu Pro Thr Lys 
705                 710                 715                 720 


Val Ala Ser Gly Arg Thr Thr Pro Ala Pro Val Asn Gln Thr Asp Arg 
                725                 730                 735     


Glu Lys Glu Lys Ala Lys Ala Lys Ala Val Ala Leu Asp Ser Asp Asn 
            740                 745                 750         


Ile Ser Leu Lys Ser Ile Gly Ser Pro Glu Ser Thr Pro Lys Asn Gln 
        755                 760                 765             


Ala Ser His Pro Thr Ala Thr Lys Leu Ala Glu Leu Pro Pro Thr Pro 
    770                 775                 780                 


Leu Arg Ala Thr Ala Lys Ser Phe Val Lys Pro Pro Ser Leu Ala Asn 
785                 790                 795                 800 


Leu Asp Lys Val Asn Ser Asn Ser Leu Asp Leu Pro Ser Ser Ser Asp 
                805                 810                 815     


Thr Thr His Ala Ser Lys Val Pro Asp Leu His Ala Thr Ser Ser Ala 
            820                 825                 830         


Ser Gly Gly Pro Leu Pro Ser Cys Phe Thr Pro Ser Pro Ala Pro Ile 
        835                 840                 845             


Leu Asn Ile Asn Ser Ala Ser Phe Ser Gln Gly Leu Glu Leu Met Ser 
    850                 855                 860                 


Gly Phe Ser Val Pro Lys Glu Thr Arg Met Tyr Pro Lys Leu Ser Gly 
865                 870                 875                 880 


Leu His Arg Ser Met Glu Ser Leu Gln Met Pro Met Ser Leu Pro Ser 
                885                 890                 895     


Ala Phe Pro Ser Ser Thr Pro Val Pro Thr Pro Pro Ala Pro Pro Ala 
            900                 905                 910         


Ala Pro Thr Glu Glu Glu Thr Glu Glu Leu Thr Trp Ser Gly Ser Pro 
        915                 920                 925             


Arg Ala Gly Gln Leu Asp Ser Asn Gln Arg Asp Arg Asn Thr Leu Pro 
    930                 935                 940                 


Lys Lys Gly Leu Arg Tyr Gln Leu Gln Ser Gln Glu Glu Thr Lys Glu 
945                 950                 955                 960 


Arg Arg His Ser His Thr Ile Gly Gly Leu Pro Glu Ser Asp Asp Gln 
                965                 970                 975     


Ser Glu Leu Pro Ser Pro Pro Ala Leu Pro Met Ser Leu Ser Ala Lys 
            980                 985                 990         


Gly Gln Leu Thr Asn Ile Val Ser  Pro Thr Ala Ala Thr  Thr Pro Arg 
        995                 1000                 1005             


Ile Thr  Arg Ser Asn Ser Ile  Pro Thr His Glu Ala  Ala Phe Glu 
    1010                 1015                 1020             


Leu Tyr  Ser Gly Ser Gln Met  Gly Ser Thr Leu Ser  Leu Ala Glu 
    1025                 1030                 1035             


Arg Pro  Lys Gly Met Ile Arg  Ser Gly Ser Phe Arg  Asp Pro Thr 
    1040                 1045                 1050             


Asp Asp  Val His Gly Ser Val  Leu Ser Leu Ala Ser  Ser Ala Ser 
    1055                 1060                 1065             


Ser Thr  Tyr Ser Ser Ala Glu  Glu Arg Met Gln Ser  Glu Gln Ile 
    1070                 1075                 1080             


Arg Lys  Leu Arg Arg Glu Leu  Glu Ser Ser Gln Glu  Lys Val Ala 
    1085                 1090                 1095             


Thr Leu  Thr Ser Gln Leu Ser  Ala Asn Ala Asn Leu  Val Ala Ala 
    1100                 1105                 1110             


Phe Glu  Gln Ser Leu Val Asn  Met Thr Ser Arg Leu  Arg His Leu 
    1115                 1120                 1125             


Ala Glu  Thr Ala Glu Glu Lys  Asp Thr Glu Leu Leu  Asp Leu Arg 
    1130                 1135                 1140             


Glu Thr  Ile Asp Phe Leu Lys  Lys Lys Asn Ser Glu  Ala Gln Ala 
    1145                 1150                 1155             


Val Ile  Gln Gly Ala Leu Asn  Ala Ser Glu Thr Thr  Pro Lys Glu 
    1160                 1165                 1170             


Leu Arg  Ile Lys Arg Gln Asn  Ser Ser Asp Ser Ile  Ser Ser Leu 
    1175                 1180                 1185             


Asn Ser  Ile Thr Ser His Ser  Ser Ile Gly Ser Ser  Lys Asp Ala 
    1190                 1195                 1200             


Asp Ala  Lys Lys Lys Lys Lys  Lys Ser Trp Leu Arg  Ser Ser Phe 
    1205                 1210                 1215             


Asn Lys  Ala Phe Ser Ile Lys  Lys Gly Pro Lys Ser  Ala Ser Ser 
    1220                 1225                 1230             


Tyr Ser  Asp Ile Glu Glu Ile  Ala Thr Pro Asp Ser  Ser Ala Pro 
    1235                 1240                 1245             


Ser Ser  Pro Lys Leu Gln His  Gly Ser Thr Glu Thr  Ala Ser Pro 
    1250                 1255                 1260             


Ser Ile  Lys Ser Ser Thr Ser  Ser Ser Val Gly Thr  Asp Val Thr 
    1265                 1270                 1275             


Glu Gly  Pro Ala His Pro Ala  Pro His Thr Arg Leu  Phe His Ala 
    1280                 1285                 1290             


Asn Glu  Glu Glu Glu Pro Glu  Lys Lys Glu Val Ser  Glu Leu Arg 
    1295                 1300                 1305             


Ser Glu  Leu Trp Glu Lys Glu  Met Lys Leu Thr Asp  Ile Arg Leu 
    1310                 1315                 1320             


Glu Ala  Leu Asn Ser Ala His  Gln Leu Asp Gln Leu  Arg Glu Thr 
    1325                 1330                 1335             


Met His  Asn Met Gln Leu Glu  Val Asp Leu Leu Lys  Ala Glu Asn 
    1340                 1345                 1350             


Asp Arg  Leu Lys Val Ala Pro  Gly Pro Ser Ser Gly  Ser Thr Pro 
    1355                 1360                 1365             


Gly Gln  Val Pro Gly Ser Ser  Ala Leu Ser Ser Pro  Arg Arg Ser 
    1370                 1375                 1380             


Leu Gly  Leu Ala Leu Thr His  Ser Phe Gly Pro Ser  Leu Ala Asp 
    1385                 1390                 1395             


Thr Asp  Leu Ser Pro Met Asp  Gly Ile Ser Thr Cys  Gly Pro Lys 
    1400                 1405                 1410             


Glu Glu  Val Thr Leu Arg Val  Val Val Arg Met Pro  Pro Gln His 
    1415                 1420                 1425             


Ile Ile  Lys Gly Asp Leu Lys  Gln Gln Glu Phe Phe  Leu Gly Cys 
    1430                 1435                 1440             


Ser Lys  Val Ser Gly Lys Val  Asp Trp Lys Met Leu  Asp Glu Ala 
    1445                 1450                 1455             


Val Phe  Gln Val Phe Lys Asp  Tyr Ile Ser Lys Met  Asp Pro Ala 
    1460                 1465                 1470             


Ser Thr  Leu Gly Leu Ser Thr  Glu Ser Ile His Gly  Tyr Ser Ile 
    1475                 1480                 1485             


Ser His  Val Lys Arg Val Leu  Asp Ala Glu Pro Pro  Glu Met Pro 
    1490                 1495                 1500             


Pro Cys  Arg Arg Gly Val Asn  Asn Ile Ser Val Ser  Leu Lys Gly 
    1505                 1510                 1515             


Leu Lys  Glu Lys Cys Val Asp  Ser Leu Val Phe Glu  Thr Leu Ile 
    1520                 1525                 1530             


Pro Lys  Pro Met Met Gln His  Tyr Ile Ser Leu Leu  Leu Lys His 
    1535                 1540                 1545             


Arg Arg  Leu Val Leu Ser Gly  Pro Ser Gly Thr Gly  Lys Thr Tyr 
    1550                 1555                 1560             


Leu Thr  Asn Arg Leu Ala Glu  Tyr Leu Val Glu Arg  Ser Gly Arg 
    1565                 1570                 1575             


Glu Val  Thr Glu Gly Ile Val  Ser Thr Phe Asn Met  His Gln Gln 
    1580                 1585                 1590             


Ser Cys  Lys Asp Leu Gln Leu  Tyr Leu Ser Asn Leu  Ala Asn Gln 
    1595                 1600                 1605             


Ile Asp  Arg Glu Thr Gly Ile  Gly Asp Val Pro Leu  Val Ile Leu 
    1610                 1615                 1620             


Leu Asp  Asp Leu Ser Glu Ala  Gly Ser Ile Ser Glu  Leu Val Asn 
    1625                 1630                 1635             


Gly Ala  Leu Thr Cys Lys Tyr  His Lys Cys Pro Tyr  Ile Ile Gly 
    1640                 1645                 1650             


Thr Thr  Asn Gln Pro Val Lys  Met Thr Pro Asn His  Gly Leu His 
    1655                 1660                 1665             


Leu Ser  Phe Arg Met Leu Thr  Phe Ser Asn Asn Val  Glu Pro Ala 
    1670                 1675                 1680             


Asn Gly  Phe Leu Val Arg Tyr  Leu Arg Arg Lys Leu  Val Glu Ser 
    1685                 1690                 1695             


Asp Ser  Asp Ile Asn Ala Asn  Lys Glu Glu Leu Leu  Arg Val Leu 
    1700                 1705                 1710             


Asp Trp  Val Pro Lys Leu Trp  Tyr His Leu His Thr  Phe Leu Glu 
    1715                 1720                 1725             


Lys His  Ser Thr Ser Asp Phe  Leu Ile Gly Pro Cys  Phe Phe Leu 
    1730                 1735                 1740             


Ser Cys  Pro Ile Gly Ile Glu  Asp Phe Arg Thr Trp  Phe Ile Asp 
    1745                 1750                 1755             


Leu Trp  Asn Asn Ser Ile Ile  Pro Tyr Leu Gln Glu  Gly Ala Lys 
    1760                 1765                 1770             


Asp Gly  Ile Lys Val His Gly  Gln Lys Ala Ala Trp  Glu Asp Pro 
    1775                 1780                 1785             


Val Glu  Trp Val Arg Asp Thr  Leu Pro Trp Pro Ser  Ala Gln Gln 
    1790                 1795                 1800             


Asp Gln  Ser Lys Leu Tyr His  Leu Pro Pro Pro Thr  Val Gly Pro 
    1805                 1810                 1815             


His Ser  Ile Ala Ser Pro Pro  Glu Asp Arg Thr Val  Lys Asp Ser 
    1820                 1825                 1830             


Thr Pro  Ser Ser Leu Asp Ser  Asp Pro Leu Met Ala  Met Leu Leu 
    1835                 1840                 1845             


Lys Leu  Gln Glu Ala Ala Asn  Tyr Ile Glu Ser Pro  Asp Arg Glu 
    1850                 1855                 1860             


Thr Ile  Leu Asp Pro Asn Leu  Gln Ala Thr Leu 
    1865                 1870                 


<210>  6849
<211>  6336
<212>  DNA
<213>  Homosapiens

<400>  6849
catgctgccc aagcgcgcca aggcgcccgg cggcggcggc ggcatggcca aggccagcgc     60

ggctgagctg aaggtcttca agtccggcag cgtggacagc cgtgtccccg gcgggccgcc    120

cgcctccaac ctgcgcaagc agaagtcact caccaacctc tcttttctca cggactccga    180

gaaaaagctg cagctttatg agcccgaatg gagcgacgat atggccaagg cgcccaaagg    240

cttaggcaag gtggggtcca agggccgtga agctccgctg atgtccaaga cgctgtccaa    300

gtcggagcac tcgctcttcc aggccaaggg cagcccggcg ggcggcgcca agacccccct    360

ggctccgctc gcgcccaacc tgggaaagcc gagccggatc cctcgaggac cctatgcgga    420

ggtcaagccg ctcagcaagg cgcctgaagc ggccgtgagc gaagatggca aatcggacga    480

cgagctgctc tccagcaagg ccaaggcgca aaagagctct gggcctgtcc cctctgccaa    540

gggccaggag gagcgcgcct tcctcaaggt ggaccccgag ctggtggtga ccgtgctggg    600

agacctggag cagctgctct tcagccagat gctggaccca gagtcccaga gaaagaggac    660

agtgcagaat gtcctggatc tccggcagaa cctggaagag accatgtcca gcctgcgagg    720

gtcccaggtg actcacagct ccctggagat gacctgctac gacagcgatg atgccaaccc    780

acgcagcgtg tccagcctct ccaaccgctc gtcccctctg tcatggcgct atggccagtc    840

cagtccgcgg ctgcaggctg gtgacgcgcc ctctgtgggt gggagctgcc gctcggaggg    900

gacgcccgcc tggtacatgc acggcgaacg ggcccactac tcccacacca tgcccatgcg    960

cagccccagc aagctcagcc atatctcccg cctggagctg gtcgaatccc tggactcgga   1020

tgaggtggac ctcaagtccg gctacatgag cgacagtgac ctcatgggca agaccatgac   1080

ggaggatgat gacatcacta ccggctggga tgaaagcagc tccatcagta gtggactcag   1140

cgatgcctca gacaatctca gttcagaaga attcaatgcc agctcctcac tcaactccct   1200

cccaagtact cccactgctt ctcgcaggaa ctcaacaata gtgctacgca cagactcaga   1260

gaagcgctca ctggcagaaa gtgggctgag ctggtttagt gaatcagagg agaaagcccc   1320

taaaaaactg gagtacgaca gtggtagcct gaagatggaa cctgggactt ctaagtggcg   1380

gagggagcgg cctgagagct gtgatgattc atccaagggt ggagaactga aaaagcccat   1440

cagcctgggc caccctggtt ccctgaagaa gggcaagacc ccacctgtgg ctgtaacttc   1500

ccccatcact cacacagccc agagtgccct caaagtcgca ggcaaacctg agggcaaagc   1560

tacagacaag ggtaagcttg cagtgaagaa tactgggctc caacgctcct cctctgatgc   1620

tggtcgggac cgcctgagtg atgctaagaa gcccccctcg ggcattgctc gcccctccac   1680

ttcgggatcc tttggctaca agaagcctcc tcctgccaca ggcacagcca ctgtcatgca   1740

aactggtggt tcagccactc tcagcaagat ccagaagtcc tcaggcatcc ctgtcaagcc   1800

agtaaatggg cgcaagacta gcttagatgt ttccaacagt gcagagccag gattcctggc   1860

tcctggagcc cgttctaaca tccagtaccg cagcctgccc cggccagcca agtcaagttc   1920

tatgagcgtg accggcgggc ggggtggacc tcgccctgtg agcagcagca ttgaccccag   1980

tctcctcagc accaagcagg gaggccttac gccttccaga ctgaaggagc ctaccaaggt   2040

agccagtggg cggaccactc cagcccctgt caatcagaca gatcgggaaa aggagaaggc   2100

caaagccaag gcagtggcct tggactcaga caacatctcc ttgaagagta ttggctcccc   2160

agaaagtact cccaagaacc aagcaagcca ccccacagcc accaagctgg cagagctgcc   2220

accaacccct ctcagggcca cagcgaagag ctttgtcaaa ccaccctcac tagccaatct   2280

tgacaaggtc aactccaaca gtctggatct accatcatcc agtgatacca cccatgcttc   2340

aaaggtccca gatctgcatg ctacaagctc agcatctggg ggccctctcc cttcctgctt   2400

cacccccagt ccggcaccca tcctcaatat taactcagcc agcttctccc agggcctgga   2460

gctaatgagt ggtttcagtg tgccaaaaga gacccgcatg taccccaaac tctcaggcct   2520

gcacaggagc atggagtccc tccagatgcc aatgagcctc cccagtgcct tccccagcag   2580

tactcccgtc cccaccccac ctgctccccc tgctgctccc acagaagaag agacggaaga   2640

gctgacttgg agtggaagcc ccagagctgg gcaactggac agtaatcagc gggatcggaa   2700

cactcttccc aagaaagggc tcaggtacca gcttcagtcc caggaggaga ccaaggagag   2760

gcgacattcc cataccattg gtgggctgcc tgaatccgat gaccagtcag agctgccttc   2820

tccccctgca cttcccatgt ctctgagtgc aaagggccaa cttaccaaca tagtgagtcc   2880

cactgcggcc accacgccaa gaatcacccg ctccaacagc atccccaccc acgaggcggc   2940

cttcgagctg tacagcggct cccaaatggg gagcaccctg tccctggccg agagacccaa   3000

gggaatgatt cggtcaggat ccttccgaga ccccacggac gatgttcacg gctcagtgct   3060

gtccctggcc tccagtgcct cctccaccta ctcctcagct gaggagagga tgcaatctga   3120

gcaaatccgg aagcttcgta gggaactgga atcatcccag gaaaaagtgg ccaccttgac   3180

gtctcagctt tctgccaatg ctaatctggt ggctgctttt gagcagagcc tggtgaatat   3240

gacatcccgc ctgcgacacc tggcagagac ggccgaggag aaggacactg agctgctgga   3300

tttgcgagaa accatagact ttctgaagaa aaagaactct gaggcccagg cagtcattca   3360

gggagccctt aatgcctcag aaaccacacc caaagaactt cggatcaaga gacaaaactc   3420

ctcagatagc atctcaagcc tcaacagcat cactagccat tccagcatcg gcagcagcaa   3480

ggatgctgat gcgaaaaaga agaaaaaaaa gagttggctt cgaagttcct tcaacaaagc   3540

gttcagtata aaaaaggggc ccaagtcagc ttcctcatac tcggatatag aggagattgc   3600

tacacccgac tcttcagccc cctcatcccc caaactacag catggttcta cagagactgc   3660

ttcaccctcc atcaagtcct ccacctcgtc ctccgtgggc actgatgtca ccgagggccc   3720

tgctcaccca gccccccaca ctaggctgtt ccatgcaaat gaggaggagg agccagagaa   3780

gaaggaggta tcggagctgc gctctgagct atgggagaag gaaatgaagc ttacagacat   3840

ccgcttggag gccctcaact ctgcccacca actggatcag cttcgggaga ccatgcacaa   3900

catgcagttg gaggtggacc tgctgaaagc agagaatgac cgactgaagg tagccccagg   3960

cccctcatca ggctccactc cagggcaggt ccctggatca tctgcattat cttccccacg   4020

ccgctcccta ggcctggcac tcacccattc cttcggcccc agtcttgcag acacagacct   4080

gtcacccatg gatggcatca gtacttgtgg tccaaaggag gaagtgaccc tccgggtggt   4140

ggtgaggatg cccccgcagc acatcatcaa aggggacttg aagcagcagg aattcttcct   4200

gggctgtagc aaggtcagtg gaaaagttga ctggaagatg ctggatgaag ctgttttcca   4260

agtgttcaag gactatattt ctaaaatgga cccagcctct accctgggac taagcactga   4320

gtccatccat ggctacagca tcagccacgt gaaacgagtg ttggatgcag agccccccga   4380

gatgcctcct tgccgtcgag gtgtcaataa catatcagtc tccctcaaag gtctgaagga   4440

gaaatgcgtc gacagcctgg tgttcgagac gctgatcccc aagccgatga tgcagcacta   4500

cataagcctc ctgctgaagc accggcgcct cgtcctctcg ggccccagcg gcacgggcaa   4560

gacctacctg accaatcgct tggccgagta cctggtggag cgctctggcc gtgaggtcac   4620

agagggcatc gtcagcacct tcaacatgca ccagcagtct tgcaaggatc tgcaactgta   4680

tctttccaac ctagccaacc agatagaccg ggaaacagga attggggatg tgcccctggt   4740

gattctattg gatgacctga gtgaagcagg ctccatcagt gagttggtca atggggccct   4800

cacctgcaag tatcataaat gtccctatat tataggtacc accaatcagc ctgtaaaaat   4860

gacacccaac catggcttgc acttgagctt caggatgttg accttctcca acaacgtgga   4920

gccagccaat ggcttcctgg ttcgttacct gaggaggaag ctggtagagt cagacagcga   4980

catcaatgcc aacaaggaag agctgcttcg ggtgctcgac tgggtaccca agctgtggta   5040

tcatctccac accttccttg agaagcacag cacctcagac ttcctcatcg gcccttgctt   5100

ctttctgtcg tgtcccattg gcattgagga cttccggacc tggttcattg acctgtggaa   5160

caactctatc attccctatc tacaggaagg agccaaggat gggataaagg tccatggaca   5220

gaaagctgct tgggaggacc cagtggaatg ggtccgggac acacttccct ggccatcagc   5280

ccaacaagac caatcaaagc tgtaccacct gcccccaccc accgtgggcc ctcacagcat   5340

tgcctcacct cccgaggata ggacagtcaa agacagcacc ccaagttctc tggactcaga   5400

tcctctgatg gccatgctgc tgaaacttca agaagctgcc aactacattg agtctccaga   5460

tcgagaaacc atcctggacc ccaaccttca ggcaacactt taagggttcg gcaatcactg   5520

tcacccccgg acagcagaac gctggcatca gctatcttag ctcctcctct cccctctcct   5580

ctttcagagc actggctctc cagccccagg aggagaacag gagggaggag gagatgaaag   5640

aggagggaca ggttcttggt gctgtacctt tgagaacttc ctaggaagga atggtggggt   5700

ggcgtttggg aacttgtgcc ccctaaacac atttactggc ctcctctaat gactttgggg   5760

aaaagatgat tctgggtctt tcccttgact tcttgtttca attacaaact cctgggcttt   5820

ctggggaggg gttcagaaaa catcaaaaca ctgcagcagt tcctaaatga ttctcacaag   5880

caaccctgag agagacagtc ttgtgaggga gatctggggg aggcaggaag ctcctcagat   5940

tttctcacag acccttccca attccatcac cactgccaac aactcctccc ccagagatct   6000

ggctggagcc cagaaaaaga agcatgtggt ttaaaaaatg tttaaatcaa tctgtaaaag   6060

gtaaaaatga aaaacaaaaa caagcaaaca aacaaaaaac aatggaaaag atgaagctgg   6120

agagagagga accagttgcc aaggtagaga gctgcccgct cctgccctct ggatgacata   6180

ggggacatca acaagacggc tgccaacctg agaagtcacc aaaccacaaa aataacctta   6240

cagccttcag ggaaagacta ccagctctgt ctttctaccc tctaatttaa caatgcataa   6300

gagtcaataa accctacttt tttatttttg gttttt                             6336


<210>  6850
<211>  1833
<212>  PRT
<213>  Homosapiens

<400>  6850

Met Leu Pro Lys Arg Ala Lys Ala Pro Gly Gly Gly Gly Gly Met Ala 
1               5                   10                  15      


Lys Ala Ser Ala Ala Glu Leu Lys Val Phe Lys Ser Gly Ser Val Asp 
            20                  25                  30          


Ser Arg Val Pro Gly Gly Pro Pro Ala Ser Asn Leu Arg Lys Gln Lys 
        35                  40                  45              


Ser Leu Thr Asn Leu Ser Phe Leu Thr Asp Ser Glu Lys Lys Leu Gln 
    50                  55                  60                  


Leu Tyr Glu Pro Glu Trp Ser Asp Asp Met Ala Lys Ala Pro Lys Gly 
65                  70                  75                  80  


Leu Gly Lys Val Gly Ser Lys Gly Arg Glu Ala Pro Leu Met Ser Lys 
                85                  90                  95      


Thr Leu Ser Lys Ser Glu His Ser Leu Phe Gln Ala Lys Gly Ser Pro 
            100                 105                 110         


Ala Gly Gly Ala Lys Thr Pro Leu Ala Pro Leu Ala Pro Asn Leu Gly 
        115                 120                 125             


Lys Pro Ser Arg Ile Pro Arg Gly Pro Tyr Ala Glu Val Lys Pro Leu 
    130                 135                 140                 


Ser Lys Ala Pro Glu Ala Ala Val Ser Glu Asp Gly Lys Ser Asp Asp 
145                 150                 155                 160 


Glu Leu Leu Ser Ser Lys Ala Lys Ala Gln Lys Ser Ser Gly Pro Val 
                165                 170                 175     


Pro Ser Ala Lys Gly Gln Glu Glu Arg Ala Phe Leu Lys Val Asp Pro 
            180                 185                 190         


Glu Leu Val Val Thr Val Leu Gly Asp Leu Glu Gln Leu Leu Phe Ser 
        195                 200                 205             


Gln Met Leu Asp Pro Glu Ser Gln Arg Lys Arg Thr Val Gln Asn Val 
    210                 215                 220                 


Leu Asp Leu Arg Gln Asn Leu Glu Glu Thr Met Ser Ser Leu Arg Gly 
225                 230                 235                 240 


Ser Gln Val Thr His Ser Ser Leu Glu Met Thr Cys Tyr Asp Ser Asp 
                245                 250                 255     


Asp Ala Asn Pro Arg Ser Val Ser Ser Leu Ser Asn Arg Ser Ser Pro 
            260                 265                 270         


Leu Ser Trp Arg Tyr Gly Gln Ser Ser Pro Arg Leu Gln Ala Gly Asp 
        275                 280                 285             


Ala Pro Ser Val Gly Gly Ser Cys Arg Ser Glu Gly Thr Pro Ala Trp 
    290                 295                 300                 


Tyr Met His Gly Glu Arg Ala His Tyr Ser His Thr Met Pro Met Arg 
305                 310                 315                 320 


Ser Pro Ser Lys Leu Ser His Ile Ser Arg Leu Glu Leu Val Glu Ser 
                325                 330                 335     


Leu Asp Ser Asp Glu Val Asp Leu Lys Ser Gly Tyr Met Ser Asp Ser 
            340                 345                 350         


Asp Leu Met Gly Lys Thr Met Thr Glu Asp Asp Asp Ile Thr Thr Gly 
        355                 360                 365             


Trp Asp Glu Ser Ser Ser Ile Ser Ser Gly Leu Ser Asp Ala Ser Asp 
    370                 375                 380                 


Asn Leu Ser Ser Glu Glu Phe Asn Ala Ser Ser Ser Leu Asn Ser Leu 
385                 390                 395                 400 


Pro Ser Thr Pro Thr Ala Ser Arg Arg Asn Ser Thr Ile Val Leu Arg 
                405                 410                 415     


Thr Asp Ser Glu Lys Arg Ser Leu Ala Glu Ser Gly Leu Ser Trp Phe 
            420                 425                 430         


Ser Glu Ser Glu Glu Lys Ala Pro Lys Lys Leu Glu Tyr Asp Ser Gly 
        435                 440                 445             


Ser Leu Lys Met Glu Pro Gly Thr Ser Lys Trp Arg Arg Glu Arg Pro 
    450                 455                 460                 


Glu Ser Cys Asp Asp Ser Ser Lys Gly Gly Glu Leu Lys Lys Pro Ile 
465                 470                 475                 480 


Ser Leu Gly His Pro Gly Ser Leu Lys Lys Gly Lys Thr Pro Pro Val 
                485                 490                 495     


Ala Val Thr Ser Pro Ile Thr His Thr Ala Gln Ser Ala Leu Lys Val 
            500                 505                 510         


Ala Gly Lys Pro Glu Gly Lys Ala Thr Asp Lys Gly Lys Leu Ala Val 
        515                 520                 525             


Lys Asn Thr Gly Leu Gln Arg Ser Ser Ser Asp Ala Gly Arg Asp Arg 
    530                 535                 540                 


Leu Ser Asp Ala Lys Lys Pro Pro Ser Gly Ile Ala Arg Pro Ser Thr 
545                 550                 555                 560 


Ser Gly Ser Phe Gly Tyr Lys Lys Pro Pro Pro Ala Thr Gly Thr Ala 
                565                 570                 575     


Thr Val Met Gln Thr Gly Gly Ser Ala Thr Leu Ser Lys Ile Gln Lys 
            580                 585                 590         


Ser Ser Gly Ile Pro Val Lys Pro Val Asn Gly Arg Lys Thr Ser Leu 
        595                 600                 605             


Asp Val Ser Asn Ser Ala Glu Pro Gly Phe Leu Ala Pro Gly Ala Arg 
    610                 615                 620                 


Ser Asn Ile Gln Tyr Arg Ser Leu Pro Arg Pro Ala Lys Ser Ser Ser 
625                 630                 635                 640 


Met Ser Val Thr Gly Gly Arg Gly Gly Pro Arg Pro Val Ser Ser Ser 
                645                 650                 655     


Ile Asp Pro Ser Leu Leu Ser Thr Lys Gln Gly Gly Leu Thr Pro Ser 
            660                 665                 670         


Arg Leu Lys Glu Pro Thr Lys Val Ala Ser Gly Arg Thr Thr Pro Ala 
        675                 680                 685             


Pro Val Asn Gln Thr Asp Arg Glu Lys Glu Lys Ala Lys Ala Lys Ala 
    690                 695                 700                 


Val Ala Leu Asp Ser Asp Asn Ile Ser Leu Lys Ser Ile Gly Ser Pro 
705                 710                 715                 720 


Glu Ser Thr Pro Lys Asn Gln Ala Ser His Pro Thr Ala Thr Lys Leu 
                725                 730                 735     


Ala Glu Leu Pro Pro Thr Pro Leu Arg Ala Thr Ala Lys Ser Phe Val 
            740                 745                 750         


Lys Pro Pro Ser Leu Ala Asn Leu Asp Lys Val Asn Ser Asn Ser Leu 
        755                 760                 765             


Asp Leu Pro Ser Ser Ser Asp Thr Thr His Ala Ser Lys Val Pro Asp 
    770                 775                 780                 


Leu His Ala Thr Ser Ser Ala Ser Gly Gly Pro Leu Pro Ser Cys Phe 
785                 790                 795                 800 


Thr Pro Ser Pro Ala Pro Ile Leu Asn Ile Asn Ser Ala Ser Phe Ser 
                805                 810                 815     


Gln Gly Leu Glu Leu Met Ser Gly Phe Ser Val Pro Lys Glu Thr Arg 
            820                 825                 830         


Met Tyr Pro Lys Leu Ser Gly Leu His Arg Ser Met Glu Ser Leu Gln 
        835                 840                 845             


Met Pro Met Ser Leu Pro Ser Ala Phe Pro Ser Ser Thr Pro Val Pro 
    850                 855                 860                 


Thr Pro Pro Ala Pro Pro Ala Ala Pro Thr Glu Glu Glu Thr Glu Glu 
865                 870                 875                 880 


Leu Thr Trp Ser Gly Ser Pro Arg Ala Gly Gln Leu Asp Ser Asn Gln 
                885                 890                 895     


Arg Asp Arg Asn Thr Leu Pro Lys Lys Gly Leu Arg Tyr Gln Leu Gln 
            900                 905                 910         


Ser Gln Glu Glu Thr Lys Glu Arg Arg His Ser His Thr Ile Gly Gly 
        915                 920                 925             


Leu Pro Glu Ser Asp Asp Gln Ser Glu Leu Pro Ser Pro Pro Ala Leu 
    930                 935                 940                 


Pro Met Ser Leu Ser Ala Lys Gly Gln Leu Thr Asn Ile Val Ser Pro 
945                 950                 955                 960 


Thr Ala Ala Thr Thr Pro Arg Ile Thr Arg Ser Asn Ser Ile Pro Thr 
                965                 970                 975     


His Glu Ala Ala Phe Glu Leu Tyr Ser Gly Ser Gln Met Gly Ser Thr 
            980                 985                 990         


Leu Ser Leu Ala Glu Arg Pro Lys  Gly Met Ile Arg Ser  Gly Ser Phe 
        995                 1000                 1005             


Arg Asp  Pro Thr Asp Asp Val  His Gly Ser Val Leu  Ser Leu Ala 
    1010                 1015                 1020             


Ser Ser  Ala Ser Ser Thr Tyr  Ser Ser Ala Glu Glu  Arg Met Gln 
    1025                 1030                 1035             


Ser Glu  Gln Ile Arg Lys Leu  Arg Arg Glu Leu Glu  Ser Ser Gln 
    1040                 1045                 1050             


Glu Lys  Val Ala Thr Leu Thr  Ser Gln Leu Ser Ala  Asn Ala Asn 
    1055                 1060                 1065             


Leu Val  Ala Ala Phe Glu Gln  Ser Leu Val Asn Met  Thr Ser Arg 
    1070                 1075                 1080             


Leu Arg  His Leu Ala Glu Thr  Ala Glu Glu Lys Asp  Thr Glu Leu 
    1085                 1090                 1095             


Leu Asp  Leu Arg Glu Thr Ile  Asp Phe Leu Lys Lys  Lys Asn Ser 
    1100                 1105                 1110             


Glu Ala  Gln Ala Val Ile Gln  Gly Ala Leu Asn Ala  Ser Glu Thr 
    1115                 1120                 1125             


Thr Pro  Lys Glu Leu Arg Ile  Lys Arg Gln Asn Ser  Ser Asp Ser 
    1130                 1135                 1140             


Ile Ser  Ser Leu Asn Ser Ile  Thr Ser His Ser Ser  Ile Gly Ser 
    1145                 1150                 1155             


Ser Lys  Asp Ala Asp Ala Lys  Lys Lys Lys Lys Lys  Ser Trp Leu 
    1160                 1165                 1170             


Arg Ser  Ser Phe Asn Lys Ala  Phe Ser Ile Lys Lys  Gly Pro Lys 
    1175                 1180                 1185             


Ser Ala  Ser Ser Tyr Ser Asp  Ile Glu Glu Ile Ala  Thr Pro Asp 
    1190                 1195                 1200             


Ser Ser  Ala Pro Ser Ser Pro  Lys Leu Gln His Gly  Ser Thr Glu 
    1205                 1210                 1215             


Thr Ala  Ser Pro Ser Ile Lys  Ser Ser Thr Ser Ser  Ser Val Gly 
    1220                 1225                 1230             


Thr Asp  Val Thr Glu Gly Pro  Ala His Pro Ala Pro  His Thr Arg 
    1235                 1240                 1245             


Leu Phe  His Ala Asn Glu Glu  Glu Glu Pro Glu Lys  Lys Glu Val 
    1250                 1255                 1260             


Ser Glu  Leu Arg Ser Glu Leu  Trp Glu Lys Glu Met  Lys Leu Thr 
    1265                 1270                 1275             


Asp Ile  Arg Leu Glu Ala Leu  Asn Ser Ala His Gln  Leu Asp Gln 
    1280                 1285                 1290             


Leu Arg  Glu Thr Met His Asn  Met Gln Leu Glu Val  Asp Leu Leu 
    1295                 1300                 1305             


Lys Ala  Glu Asn Asp Arg Leu  Lys Val Ala Pro Gly  Pro Ser Ser 
    1310                 1315                 1320             


Gly Ser  Thr Pro Gly Gln Val  Pro Gly Ser Ser Ala  Leu Ser Ser 
    1325                 1330                 1335             


Pro Arg  Arg Ser Leu Gly Leu  Ala Leu Thr His Ser  Phe Gly Pro 
    1340                 1345                 1350             


Ser Leu  Ala Asp Thr Asp Leu  Ser Pro Met Asp Gly  Ile Ser Thr 
    1355                 1360                 1365             


Cys Gly  Pro Lys Glu Glu Val  Thr Leu Arg Val Val  Val Arg Met 
    1370                 1375                 1380             


Pro Pro  Gln His Ile Ile Lys  Gly Asp Leu Lys Gln  Gln Glu Phe 
    1385                 1390                 1395             


Phe Leu  Gly Cys Ser Lys Val  Ser Gly Lys Val Asp  Trp Lys Met 
    1400                 1405                 1410             


Leu Asp  Glu Ala Val Phe Gln  Val Phe Lys Asp Tyr  Ile Ser Lys 
    1415                 1420                 1425             


Met Asp  Pro Ala Ser Thr Leu  Gly Leu Ser Thr Glu  Ser Ile His 
    1430                 1435                 1440             


Gly Tyr  Ser Ile Ser His Val  Lys Arg Val Leu Asp  Ala Glu Pro 
    1445                 1450                 1455             


Pro Glu  Met Pro Pro Cys Arg  Arg Gly Val Asn Asn  Ile Ser Val 
    1460                 1465                 1470             


Ser Leu  Lys Gly Leu Lys Glu  Lys Cys Val Asp Ser  Leu Val Phe 
    1475                 1480                 1485             


Glu Thr  Leu Ile Pro Lys Pro  Met Met Gln His Tyr  Ile Ser Leu 
    1490                 1495                 1500             


Leu Leu  Lys His Arg Arg Leu  Val Leu Ser Gly Pro  Ser Gly Thr 
    1505                 1510                 1515             


Gly Lys  Thr Tyr Leu Thr Asn  Arg Leu Ala Glu Tyr  Leu Val Glu 
    1520                 1525                 1530             


Arg Ser  Gly Arg Glu Val Thr  Glu Gly Ile Val Ser  Thr Phe Asn 
    1535                 1540                 1545             


Met His  Gln Gln Ser Cys Lys  Asp Leu Gln Leu Tyr  Leu Ser Asn 
    1550                 1555                 1560             


Leu Ala  Asn Gln Ile Asp Arg  Glu Thr Gly Ile Gly  Asp Val Pro 
    1565                 1570                 1575             


Leu Val  Ile Leu Leu Asp Asp  Leu Ser Glu Ala Gly  Ser Ile Ser 
    1580                 1585                 1590             


Glu Leu  Val Asn Gly Ala Leu  Thr Cys Lys Tyr His  Lys Cys Pro 
    1595                 1600                 1605             


Tyr Ile  Ile Gly Thr Thr Asn  Gln Pro Val Lys Met  Thr Pro Asn 
    1610                 1615                 1620             


His Gly  Leu His Leu Ser Phe  Arg Met Leu Thr Phe  Ser Asn Asn 
    1625                 1630                 1635             


Val Glu  Pro Ala Asn Gly Phe  Leu Val Arg Tyr Leu  Arg Arg Lys 
    1640                 1645                 1650             


Leu Val  Glu Ser Asp Ser Asp  Ile Asn Ala Asn Lys  Glu Glu Leu 
    1655                 1660                 1665             


Leu Arg  Val Leu Asp Trp Val  Pro Lys Leu Trp Tyr  His Leu His 
    1670                 1675                 1680             


Thr Phe  Leu Glu Lys His Ser  Thr Ser Asp Phe Leu  Ile Gly Pro 
    1685                 1690                 1695             


Cys Phe  Phe Leu Ser Cys Pro  Ile Gly Ile Glu Asp  Phe Arg Thr 
    1700                 1705                 1710             


Trp Phe  Ile Asp Leu Trp Asn  Asn Ser Ile Ile Pro  Tyr Leu Gln 
    1715                 1720                 1725             


Glu Gly  Ala Lys Asp Gly Ile  Lys Val His Gly Gln  Lys Ala Ala 
    1730                 1735                 1740             


Trp Glu  Asp Pro Val Glu Trp  Val Arg Asp Thr Leu  Pro Trp Pro 
    1745                 1750                 1755             


Ser Ala  Gln Gln Asp Gln Ser  Lys Leu Tyr His Leu  Pro Pro Pro 
    1760                 1765                 1770             


Thr Val  Gly Pro His Ser Ile  Ala Ser Pro Pro Glu  Asp Arg Thr 
    1775                 1780                 1785             


Val Lys  Asp Ser Thr Pro Ser  Ser Leu Asp Ser Asp  Pro Leu Met 
    1790                 1795                 1800             


Ala Met  Leu Leu Lys Leu Gln  Glu Ala Ala Asn Tyr  Ile Glu Ser 
    1805                 1810                 1815             


Pro Asp  Arg Glu Thr Ile Leu  Asp Pro Asn Leu Gln  Ala Thr Leu 
    1820                 1825                 1830             


<210>  6851
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  6851
catgctgccc aagcgcgcca aggcgcccgg cggcggcggc ggcatggcca aggccagcgc     60

ggctgagctg aaggtcttca agtccggcag cgtggacagc cgtgtccccg gcgggccgcc    120

cgcctccaac ctgcgcaagc agaagtcact caccaacctc tcttttctca cggactccga    180

gaaaaagctg cagctttatg agcccgaatg gagcgacgat atggccaagg cgcccaaagg    240

cttaggcaag gtggggtcca agggccgtga agctccgctg atgtccaaga cgctgtccaa    300

gtcggagcac tcgctcttcc aggccaaggg cagcccggcg ggcggcgcca agacccccct    360

ggctccgctc gcgcccaacc tgggaaagcc gagccggatc cctcgaggac cctatgcgga    420

ggtcaagccg ctcagcaagg cgcctgaagc ggccgtgagc gaagatggca aatcggacga    480

cgagctgctc tccagcaagg ccaaggcgca aaagagctct gggcctgtcc cctctgccaa    540

gggccaggag gagcgcgcct tcctcaaggt ggaccccgag ctggtggtga ccgtgctggg    600

agacctggag cagctgctct tcagccagat gctggaccca gagtcccaga gaaagaggac    660

agtgcagaat gtcctggatc tccggcagaa cctggaagag accatgtcca gcctgcgagg    720

gtcccaggtg actcacagct ccctggagat gacctgctac gacagcgatg atgccaaccc    780

acgcagcgtg tccagcctct ccaaccgctc gtcccctctg tcatggcgct atggccagtc    840

cagtccgcgg ctgcaggctg gtgacgcgcc ctctgtgggt gggagctgcc gctcggaggg    900

gacgcccgcc tggtacatgc acggcgaacg ggcccactac tcccacacca tgcccatgcg    960

cagccccagc aagctcagcc atatctcccg cctggagctg gtcgaatccc tggactcgga   1020

tgaggtggac ctcaagtccg gctacatgag cgacagtgac ctcatgggca agaccatgac   1080

ggaggatgat gacatcacta ccggctggga tgaaagcagc tccatcagta gtggactcag   1140

cgatgcctca gacaatctca gttcagaaga attcaatgcc agctcctcac tcaactccct   1200

cccaagtact cccactgctt ctcgcaggaa ctcaacaata gtgctacgca cagactcaga   1260

gaagcgctca ctggcagaaa gtgggctgag ctggtttagt gaatcagagg agaaagcccc   1320

taaaaaactg gagtacgaca gtggtagcct gaagatggaa cctgggactt ctaagtggcg   1380

gagggagcgg cctgagagct gtgatgattc atccaagggt ggagaactga aaaagcccat   1440

cagcctgggc caccctggtt ccctgaagaa gggcaagacc ccacctgtgg ctgtaacttc   1500

ccccatcact cacacagccc agagtgccct caaagtcgca ggcaaacctg agggcaaagc   1560

tacagacaag ggtaagcttg cagtgaagaa tactgggctc caacgctcct cctctgatgc   1620

tggtcgggac cgcctgagtg atgctaagaa gcccccctcg ggcattgctc gcccctccac   1680

ttcgggatcc tttggctaca agaagcctcc tcctgccaca ggcacagcca ctgtcatgca   1740

aactggtggt tcagccactc tcagcaagat ccagaagtcc tcaggcatcc ctgtcaagcc   1800

agtaaatggg cgcaagacta gcttagatgt ttccaacagt gcagagccag gattcctggc   1860

tcctggagcc cgttctaaca tccagtaccg cagcctgccc cggccagcca agtcaagttc   1920

tatgagcgtg accggcgggc ggggtggacc tcgccctgtg agcagcagca ttgaccccag   1980

tctcctcagc accaagcagg gaggccttac gccttccaga ctgaaggagc ctaccaaggt   2040

agccagtggg cggaccactc cagcccctgt caatcagaca gatcgggaaa aggagaaggc   2100

caaagccaag gcagtggcct tggactcaga caacatctcc ttgaagagta ttggctcccc   2160

agaaagtact cccaagaacc aagcaagcca ccccacagcc accaagctgg cagagctgcc   2220

accaacccct ctcagggcca cagcgaagag ctttgtcaaa ccaccctcac tagccaatct   2280

tgacaaggtc aactccaaca gtctggatct accatcatcc agtgatacca cccatgcttc   2340

aaaggtccca gatctgcatg ctacaagctc agcatctggg ggccctctcc cttcctgctt   2400

cacccccagt ccggcaccca tcctcaatat taactcagcc agcttctccc agggcctgga   2460

gctaatgagt ggtttcagtg tgccaaaaga gacccgcatg taccccaaac tctcaggcct   2520

gcacaggagc atggagtccc tccagatgcc aatgagcctc cccagtgcct tccccagcag   2580

tactcccgtc cccaccccac ctgctccccc tgctgctccc acagaagaag agacggaaga   2640

gctgacttgg agtggaagcc ccagagctgg gcaactggac agtaatcagc gggatcggaa   2700

cactcttccc aagaaagggc tcaggtacca gcttcagtcc caggaggaga ccaaggagag   2760

gcgacattcc cataccattg gtgggctgcc tgaatccgat gaccagtcag agctgccttc   2820

tccccctgca cttcccatgt ctctgagtgc aaagggccaa cttaccaaca tagtgagtcc   2880

cactgcggcc accacgccaa gaatcacccg ctccaacagc atccccaccc acgaggcggc   2940

cttcgagctg tacagcggct cccaaatggg gagcaccctg tccctggccg agagacccaa   3000

gggaatgatt cggtcaggat ccttccgaga ccccacggac gatgttcacg gctcagtgct   3060

gtccctggcc tccagtgcct cctccaccta ctcctcagct gaggagagga tgcaatctga   3120

gcaaatccgg aagcttcgta gggaactgga atcatcccag gaaaaagtgg ccaccttgac   3180

gtctcagctt tctgccaatg ctaatctggt ggctgctttt gagcagagcc tggtgaatat   3240

gacatcccgc ctgcgacacc tggcagagac ggccgaggag aaggacactg agctgctgga   3300

tttgcgagaa accatagact ttctgaagaa aaagaactct gaggcccagg cagtcattca   3360

gggagccctt aatgcctcag aaaccacacc caaagaactt cggatcaaga gacaaaactc   3420

ctcagatagc atctcaagcc tcaacagcat cactagccat tccagcatcg gcagcagcaa   3480

ggatgctgat gcgaaaaaga agaaaaaaaa gagttggctt cgaagttcct tcaacaaagc   3540

gttcagtata aaaaaggggc ccaagtcagc ttcctcatac tcggatatag aggagattgc   3600

tacacccgac tcttcagccc cctcatcccc caaactacag catggttcta cagagactgc   3660

ttcaccctcc atcaagtcct ccacctcgtc ctccgtgggc actgatgtca ccgagggccc   3720

tgctcaccca gccccccaca ctaggctgtt ccatgcaaat gaggaggagg agccagagaa   3780

gaaggaggta tcggagctgc gctctgagct atgggagaag gaaatgaagc ttacagacat   3840

ccgcttggag gccctcaact ctgcccacca actggatcag cttcgggaga ccatgcacaa   3900

catgcagttg gaggtggacc tgctgaaagc agagaatgac cgactgaagg tagccccagg   3960

cccctcatca ggctccactc cagggcaggt ccctggatca tctgcattat cttccccacg   4020

ccgctcccta ggcctggcac tcacccattc cttcggcccc agtcttgcag acacagacct   4080

gtcacccatg gatggcatca gtacttgtgg tccaaaggag gaagtgaccc tccgggtggt   4140

ggtgaggatg cccccgcagc acatcatcaa aggggacttg aagcagcagg aattcttcct   4200

gggctgtagc aaggtcagtg gaaaagttga ctggaagatg ctggatgaag ctgttttcca   4260

agtgttcaag gactatattt ctaaaatgga cccagcctct accctgggac taagcactga   4320

gtccatccat ggctacagca tcagccacgt gaaacgagtg ttggatgcag agccccccga   4380

gatgcctcct tgccgtcgag gtgtcaataa catatcagtc tccctcaaag gtctgaagga   4440

gaaatgcgtc gacagcctgg tgttcgagac gctgatcccc aagccgatga tgcagcacta   4500

cataagcctc ctgctgaagc accggcgcct cgtcctctcg ggccccagcg gcacgggcaa   4560

gacctacctg accaatcgct tggccgagta cctggtggag cgctctggcc gtgaggtcac   4620

agagggcatc gtcagcacct tcaacatgca ccagcagtct tgcaaggatc tgcaactgta   4680

tctttccaac ctagccaacc agatagaccg ggaaacagga attggggatg tgcccctggt   4740

gattctattg gatgacctga gtgaagcagg ctccatcagt gagttggtca atggggccct   4800

cacctgcaag tatcataaat gtccctatat tataggtacc accaatcagc ctgtaaaaat   4860

gacacccaac catggcttgc acttgagctt caggatgttg accttctcca acaacgtgga   4920

gccagccaat ggcttcctgg ttcgttacct gaggaggaag ctggtagagt cagacagcga   4980

catcaatgcc aacaaggaag agctgcttcg ggtgctcgac tgggtaccca agctgtggta   5040

tcatctccac accttccttg agaagcacag cacctcagac ttcctcatcg gcccttgctt   5100

ctttctgtcg tgtcccattg gcattgagga cttccggacc tggttcattg acctgtggaa   5160

caactctatc attccctatc tacaggaagg agccaaggat gggataaagg tccatggaca   5220

gaaagctgct tgggaggacc cagtggaatg ggtccgggac acacttccct ggccatcagc   5280

ccaacaagac caatcaaagc tgtaccacct gcccccaccc accgtgggcc ctcacagcat   5340

tgcctcacct cccgaggata ggacagtcaa agacagcacc ccaagttctc tggactcaga   5400

tcctctgatg gccatgctgc tgaaacttca agaagctgcc aactacattg agtctccaga   5460

tcgagaaacc atcctggacc ccaaccttca ggcaacactt taagggttcg gcaatcactg   5520

tcacccccgg acagcagaac gctggcatca gctatcttag ctcctcctct cccctctcct   5580

ctttcagagc actggctctc cagccccagg aggagaacag gagggaggag gagatgaaag   5640

aggagggaca ggttcttggt gctgtacctt tgagaacttc ctaggaagga atggtggggt   5700

ggcgtttggg aacttgtgcc ccctaaacac atttactggc ctcctctaat gactttgggg   5760

aaaagatgat tctgggtctt tcccttgact tcttgtttca attacaaact cctgggcttt   5820

ctggggaggg gttcagaaaa catcaaaaca ctgcagcagt tcctaaatga ttctcacaag   5880

caaccctgag agagacagtc ttgtgaggga gatctggggg aggcaggaag ctcctcagat   5940

tttctcacag acccttccca attccatcac cactgccaac aactcctccc ccagagatct   6000

ggctggagcc cagaaaaaga agcatgtggt ttaaaaaatg tttaaatcaa tctgtaaaag   6060

gtaaaaatga aaaacaaaaa caagcaaaca aacaaaaaac aatggaaaag atgaagctgg   6120

agagagagga accagttgcc aaggtagaga gctgcccgct cctgccctct ggatgacata   6180

ggggacatca acaagacggc tgccaacctg agaagtcacc aaaccacaaa aataacctta   6240

cagccttcag ggaaagacta ccagctctgt ctttctaccc tctaatttaa caatgcataa   6300

gagtcaataa accctacttt tttatttttg gtttttattt tgttttcatt tttttctccc   6360

atttgcctat ttattttttt gtttcccttt tttttttctt tttccgtttt tccatttcct   6420

cacatgtcca cgagatgctt gggttgcttt tccaggggct agtttggctt ttccaagtgg   6480

gttttctttg gagaatctga tgccatgcaa ttggcatgac acctgccatg ccactatctt   6540

tggcatccat ggggcttata tgagacatga agcattggct cagaagtaga gggagaagag   6600

gaacccagtt cccttgactt cccttttgag agcacacgtt ctgctgggta gctcaattgc   6660

cagcctctgt catgagaagg tatagcccca tcttgataga agagttactc cgagctttat   6720

catggaccag aggaaaacca gaaaactgaa aacattcctc tgtcttgtgg ccagtttggc   6780

ctttcactgc actattctga tggtgcctga ctgaatccaa atatcctagc tggctcttac   6840

tatttttcac aaatgagtat tcacatataa gagatgaaca tccatgtgag atcatcccaa   6900

tcagaatata agactcaagg agtttgactt ggtggccaat acctgccttc caaagagatc   6960

ctacctttgc agatttgctc ctttcccatt gccttgaagg tctggcaatc cctgttcttt   7020

catttgacaa gtacttactg agtactcact atatacaaat cattaggtta aaacagacac   7080

acacacacac acacacacac acacacacac acacacacac acaagacctg ggcccttaag   7140

tttacagtcc agcaggaaat gttaacctcc attcagctac gcccccttgt tatctagacc   7200

ttcgggatca tctaagaaat gtagctgaaa cccaaggagc cagctagaaa gaagcttttg   7260

attagatgta caatacattg ggggcagaag atctgggatc aattaagatg gagcctgaag   7320

gactatggaa tcttgcttgt caggaatggg caagtctact tcctgccatt tctgaaagcc   7380

ccgcgggacc agcttctagg ctgagctgcc tagtaggctg aagcttcagg actctgcagg   7440

tcaaggatat gtgatgagca ccggcctaag tgtttgctct tcagattcct aagtagcaca   7500

agactttatc agaatctata ggcataccaa cctggatcac tcttccaccc aaccgaggag   7560

tagatgcatc tgaatcttca tatcggtata ttaagtccaa aagatggtcc gggctgcccc   7620

tcacaaaagc ttctgcatcc acgtggtaag ctcccatgga tgacagggtt ctgtatgatg   7680

gagactatta ttgctattgc tgctaattcc atgagctgtg aagatcccta accaactcag   7740

ctgtaacata tgcaattctg tggtgggaag aggctgtgtg tccaaggatg gtgctgaaat   7800

cactgcctta aggtctctgc tgtgcagaat gaggaggccc ccgagctggc tgttctaact   7860

tagaaggaag agaagactgg atgggcctgc ttgggatcta ggcctcttct aaaccctatc   7920

ctaagctcca gttccatggc aaggctcaga cttttaatgc catcttaatc tgatggttga   7980

gcgcttcact ctattttctg gtgctgccca gccagtgcct tctgccatgg atgttactgg   8040

ctacttgaga aaaaggagag gggagaaccc cttctttcat tccaactgcc tccgacccca   8100

aagggattct tggctctctg gtaaccatgg ataccaccat gaattttatt tggatcctca   8160

gcaggttgat tctggaggcc tcatgctatg ac                                 8192


<210>  6852
<211>  1833
<212>  PRT
<213>  Homosapiens

<400>  6852

Met Leu Pro Lys Arg Ala Lys Ala Pro Gly Gly Gly Gly Gly Met Ala 
1               5                   10                  15      


Lys Ala Ser Ala Ala Glu Leu Lys Val Phe Lys Ser Gly Ser Val Asp 
            20                  25                  30          


Ser Arg Val Pro Gly Gly Pro Pro Ala Ser Asn Leu Arg Lys Gln Lys 
        35                  40                  45              


Ser Leu Thr Asn Leu Ser Phe Leu Thr Asp Ser Glu Lys Lys Leu Gln 
    50                  55                  60                  


Leu Tyr Glu Pro Glu Trp Ser Asp Asp Met Ala Lys Ala Pro Lys Gly 
65                  70                  75                  80  


Leu Gly Lys Val Gly Ser Lys Gly Arg Glu Ala Pro Leu Met Ser Lys 
                85                  90                  95      


Thr Leu Ser Lys Ser Glu His Ser Leu Phe Gln Ala Lys Gly Ser Pro 
            100                 105                 110         


Ala Gly Gly Ala Lys Thr Pro Leu Ala Pro Leu Ala Pro Asn Leu Gly 
        115                 120                 125             


Lys Pro Ser Arg Ile Pro Arg Gly Pro Tyr Ala Glu Val Lys Pro Leu 
    130                 135                 140                 


Ser Lys Ala Pro Glu Ala Ala Val Ser Glu Asp Gly Lys Ser Asp Asp 
145                 150                 155                 160 


Glu Leu Leu Ser Ser Lys Ala Lys Ala Gln Lys Ser Ser Gly Pro Val 
                165                 170                 175     


Pro Ser Ala Lys Gly Gln Glu Glu Arg Ala Phe Leu Lys Val Asp Pro 
            180                 185                 190         


Glu Leu Val Val Thr Val Leu Gly Asp Leu Glu Gln Leu Leu Phe Ser 
        195                 200                 205             


Gln Met Leu Asp Pro Glu Ser Gln Arg Lys Arg Thr Val Gln Asn Val 
    210                 215                 220                 


Leu Asp Leu Arg Gln Asn Leu Glu Glu Thr Met Ser Ser Leu Arg Gly 
225                 230                 235                 240 


Ser Gln Val Thr His Ser Ser Leu Glu Met Thr Cys Tyr Asp Ser Asp 
                245                 250                 255     


Asp Ala Asn Pro Arg Ser Val Ser Ser Leu Ser Asn Arg Ser Ser Pro 
            260                 265                 270         


Leu Ser Trp Arg Tyr Gly Gln Ser Ser Pro Arg Leu Gln Ala Gly Asp 
        275                 280                 285             


Ala Pro Ser Val Gly Gly Ser Cys Arg Ser Glu Gly Thr Pro Ala Trp 
    290                 295                 300                 


Tyr Met His Gly Glu Arg Ala His Tyr Ser His Thr Met Pro Met Arg 
305                 310                 315                 320 


Ser Pro Ser Lys Leu Ser His Ile Ser Arg Leu Glu Leu Val Glu Ser 
                325                 330                 335     


Leu Asp Ser Asp Glu Val Asp Leu Lys Ser Gly Tyr Met Ser Asp Ser 
            340                 345                 350         


Asp Leu Met Gly Lys Thr Met Thr Glu Asp Asp Asp Ile Thr Thr Gly 
        355                 360                 365             


Trp Asp Glu Ser Ser Ser Ile Ser Ser Gly Leu Ser Asp Ala Ser Asp 
    370                 375                 380                 


Asn Leu Ser Ser Glu Glu Phe Asn Ala Ser Ser Ser Leu Asn Ser Leu 
385                 390                 395                 400 


Pro Ser Thr Pro Thr Ala Ser Arg Arg Asn Ser Thr Ile Val Leu Arg 
                405                 410                 415     


Thr Asp Ser Glu Lys Arg Ser Leu Ala Glu Ser Gly Leu Ser Trp Phe 
            420                 425                 430         


Ser Glu Ser Glu Glu Lys Ala Pro Lys Lys Leu Glu Tyr Asp Ser Gly 
        435                 440                 445             


Ser Leu Lys Met Glu Pro Gly Thr Ser Lys Trp Arg Arg Glu Arg Pro 
    450                 455                 460                 


Glu Ser Cys Asp Asp Ser Ser Lys Gly Gly Glu Leu Lys Lys Pro Ile 
465                 470                 475                 480 


Ser Leu Gly His Pro Gly Ser Leu Lys Lys Gly Lys Thr Pro Pro Val 
                485                 490                 495     


Ala Val Thr Ser Pro Ile Thr His Thr Ala Gln Ser Ala Leu Lys Val 
            500                 505                 510         


Ala Gly Lys Pro Glu Gly Lys Ala Thr Asp Lys Gly Lys Leu Ala Val 
        515                 520                 525             


Lys Asn Thr Gly Leu Gln Arg Ser Ser Ser Asp Ala Gly Arg Asp Arg 
    530                 535                 540                 


Leu Ser Asp Ala Lys Lys Pro Pro Ser Gly Ile Ala Arg Pro Ser Thr 
545                 550                 555                 560 


Ser Gly Ser Phe Gly Tyr Lys Lys Pro Pro Pro Ala Thr Gly Thr Ala 
                565                 570                 575     


Thr Val Met Gln Thr Gly Gly Ser Ala Thr Leu Ser Lys Ile Gln Lys 
            580                 585                 590         


Ser Ser Gly Ile Pro Val Lys Pro Val Asn Gly Arg Lys Thr Ser Leu 
        595                 600                 605             


Asp Val Ser Asn Ser Ala Glu Pro Gly Phe Leu Ala Pro Gly Ala Arg 
    610                 615                 620                 


Ser Asn Ile Gln Tyr Arg Ser Leu Pro Arg Pro Ala Lys Ser Ser Ser 
625                 630                 635                 640 


Met Ser Val Thr Gly Gly Arg Gly Gly Pro Arg Pro Val Ser Ser Ser 
                645                 650                 655     


Ile Asp Pro Ser Leu Leu Ser Thr Lys Gln Gly Gly Leu Thr Pro Ser 
            660                 665                 670         


Arg Leu Lys Glu Pro Thr Lys Val Ala Ser Gly Arg Thr Thr Pro Ala 
        675                 680                 685             


Pro Val Asn Gln Thr Asp Arg Glu Lys Glu Lys Ala Lys Ala Lys Ala 
    690                 695                 700                 


Val Ala Leu Asp Ser Asp Asn Ile Ser Leu Lys Ser Ile Gly Ser Pro 
705                 710                 715                 720 


Glu Ser Thr Pro Lys Asn Gln Ala Ser His Pro Thr Ala Thr Lys Leu 
                725                 730                 735     


Ala Glu Leu Pro Pro Thr Pro Leu Arg Ala Thr Ala Lys Ser Phe Val 
            740                 745                 750         


Lys Pro Pro Ser Leu Ala Asn Leu Asp Lys Val Asn Ser Asn Ser Leu 
        755                 760                 765             


Asp Leu Pro Ser Ser Ser Asp Thr Thr His Ala Ser Lys Val Pro Asp 
    770                 775                 780                 


Leu His Ala Thr Ser Ser Ala Ser Gly Gly Pro Leu Pro Ser Cys Phe 
785                 790                 795                 800 


Thr Pro Ser Pro Ala Pro Ile Leu Asn Ile Asn Ser Ala Ser Phe Ser 
                805                 810                 815     


Gln Gly Leu Glu Leu Met Ser Gly Phe Ser Val Pro Lys Glu Thr Arg 
            820                 825                 830         


Met Tyr Pro Lys Leu Ser Gly Leu His Arg Ser Met Glu Ser Leu Gln 
        835                 840                 845             


Met Pro Met Ser Leu Pro Ser Ala Phe Pro Ser Ser Thr Pro Val Pro 
    850                 855                 860                 


Thr Pro Pro Ala Pro Pro Ala Ala Pro Thr Glu Glu Glu Thr Glu Glu 
865                 870                 875                 880 


Leu Thr Trp Ser Gly Ser Pro Arg Ala Gly Gln Leu Asp Ser Asn Gln 
                885                 890                 895     


Arg Asp Arg Asn Thr Leu Pro Lys Lys Gly Leu Arg Tyr Gln Leu Gln 
            900                 905                 910         


Ser Gln Glu Glu Thr Lys Glu Arg Arg His Ser His Thr Ile Gly Gly 
        915                 920                 925             


Leu Pro Glu Ser Asp Asp Gln Ser Glu Leu Pro Ser Pro Pro Ala Leu 
    930                 935                 940                 


Pro Met Ser Leu Ser Ala Lys Gly Gln Leu Thr Asn Ile Val Ser Pro 
945                 950                 955                 960 


Thr Ala Ala Thr Thr Pro Arg Ile Thr Arg Ser Asn Ser Ile Pro Thr 
                965                 970                 975     


His Glu Ala Ala Phe Glu Leu Tyr Ser Gly Ser Gln Met Gly Ser Thr 
            980                 985                 990         


Leu Ser Leu Ala Glu Arg Pro Lys  Gly Met Ile Arg Ser  Gly Ser Phe 
        995                 1000                 1005             


Arg Asp  Pro Thr Asp Asp Val  His Gly Ser Val Leu  Ser Leu Ala 
    1010                 1015                 1020             


Ser Ser  Ala Ser Ser Thr Tyr  Ser Ser Ala Glu Glu  Arg Met Gln 
    1025                 1030                 1035             


Ser Glu  Gln Ile Arg Lys Leu  Arg Arg Glu Leu Glu  Ser Ser Gln 
    1040                 1045                 1050             


Glu Lys  Val Ala Thr Leu Thr  Ser Gln Leu Ser Ala  Asn Ala Asn 
    1055                 1060                 1065             


Leu Val  Ala Ala Phe Glu Gln  Ser Leu Val Asn Met  Thr Ser Arg 
    1070                 1075                 1080             


Leu Arg  His Leu Ala Glu Thr  Ala Glu Glu Lys Asp  Thr Glu Leu 
    1085                 1090                 1095             


Leu Asp  Leu Arg Glu Thr Ile  Asp Phe Leu Lys Lys  Lys Asn Ser 
    1100                 1105                 1110             


Glu Ala  Gln Ala Val Ile Gln  Gly Ala Leu Asn Ala  Ser Glu Thr 
    1115                 1120                 1125             


Thr Pro  Lys Glu Leu Arg Ile  Lys Arg Gln Asn Ser  Ser Asp Ser 
    1130                 1135                 1140             


Ile Ser  Ser Leu Asn Ser Ile  Thr Ser His Ser Ser  Ile Gly Ser 
    1145                 1150                 1155             


Ser Lys  Asp Ala Asp Ala Lys  Lys Lys Lys Lys Lys  Ser Trp Leu 
    1160                 1165                 1170             


Arg Ser  Ser Phe Asn Lys Ala  Phe Ser Ile Lys Lys  Gly Pro Lys 
    1175                 1180                 1185             


Ser Ala  Ser Ser Tyr Ser Asp  Ile Glu Glu Ile Ala  Thr Pro Asp 
    1190                 1195                 1200             


Ser Ser  Ala Pro Ser Ser Pro  Lys Leu Gln His Gly  Ser Thr Glu 
    1205                 1210                 1215             


Thr Ala  Ser Pro Ser Ile Lys  Ser Ser Thr Ser Ser  Ser Val Gly 
    1220                 1225                 1230             


Thr Asp  Val Thr Glu Gly Pro  Ala His Pro Ala Pro  His Thr Arg 
    1235                 1240                 1245             


Leu Phe  His Ala Asn Glu Glu  Glu Glu Pro Glu Lys  Lys Glu Val 
    1250                 1255                 1260             


Ser Glu  Leu Arg Ser Glu Leu  Trp Glu Lys Glu Met  Lys Leu Thr 
    1265                 1270                 1275             


Asp Ile  Arg Leu Glu Ala Leu  Asn Ser Ala His Gln  Leu Asp Gln 
    1280                 1285                 1290             


Leu Arg  Glu Thr Met His Asn  Met Gln Leu Glu Val  Asp Leu Leu 
    1295                 1300                 1305             


Lys Ala  Glu Asn Asp Arg Leu  Lys Val Ala Pro Gly  Pro Ser Ser 
    1310                 1315                 1320             


Gly Ser  Thr Pro Gly Gln Val  Pro Gly Ser Ser Ala  Leu Ser Ser 
    1325                 1330                 1335             


Pro Arg  Arg Ser Leu Gly Leu  Ala Leu Thr His Ser  Phe Gly Pro 
    1340                 1345                 1350             


Ser Leu  Ala Asp Thr Asp Leu  Ser Pro Met Asp Gly  Ile Ser Thr 
    1355                 1360                 1365             


Cys Gly  Pro Lys Glu Glu Val  Thr Leu Arg Val Val  Val Arg Met 
    1370                 1375                 1380             


Pro Pro  Gln His Ile Ile Lys  Gly Asp Leu Lys Gln  Gln Glu Phe 
    1385                 1390                 1395             


Phe Leu  Gly Cys Ser Lys Val  Ser Gly Lys Val Asp  Trp Lys Met 
    1400                 1405                 1410             


Leu Asp  Glu Ala Val Phe Gln  Val Phe Lys Asp Tyr  Ile Ser Lys 
    1415                 1420                 1425             


Met Asp  Pro Ala Ser Thr Leu  Gly Leu Ser Thr Glu  Ser Ile His 
    1430                 1435                 1440             


Gly Tyr  Ser Ile Ser His Val  Lys Arg Val Leu Asp  Ala Glu Pro 
    1445                 1450                 1455             


Pro Glu  Met Pro Pro Cys Arg  Arg Gly Val Asn Asn  Ile Ser Val 
    1460                 1465                 1470             


Ser Leu  Lys Gly Leu Lys Glu  Lys Cys Val Asp Ser  Leu Val Phe 
    1475                 1480                 1485             


Glu Thr  Leu Ile Pro Lys Pro  Met Met Gln His Tyr  Ile Ser Leu 
    1490                 1495                 1500             


Leu Leu  Lys His Arg Arg Leu  Val Leu Ser Gly Pro  Ser Gly Thr 
    1505                 1510                 1515             


Gly Lys  Thr Tyr Leu Thr Asn  Arg Leu Ala Glu Tyr  Leu Val Glu 
    1520                 1525                 1530             


Arg Ser  Gly Arg Glu Val Thr  Glu Gly Ile Val Ser  Thr Phe Asn 
    1535                 1540                 1545             


Met His  Gln Gln Ser Cys Lys  Asp Leu Gln Leu Tyr  Leu Ser Asn 
    1550                 1555                 1560             


Leu Ala  Asn Gln Ile Asp Arg  Glu Thr Gly Ile Gly  Asp Val Pro 
    1565                 1570                 1575             


Leu Val  Ile Leu Leu Asp Asp  Leu Ser Glu Ala Gly  Ser Ile Ser 
    1580                 1585                 1590             


Glu Leu  Val Asn Gly Ala Leu  Thr Cys Lys Tyr His  Lys Cys Pro 
    1595                 1600                 1605             


Tyr Ile  Ile Gly Thr Thr Asn  Gln Pro Val Lys Met  Thr Pro Asn 
    1610                 1615                 1620             


His Gly  Leu His Leu Ser Phe  Arg Met Leu Thr Phe  Ser Asn Asn 
    1625                 1630                 1635             


Val Glu  Pro Ala Asn Gly Phe  Leu Val Arg Tyr Leu  Arg Arg Lys 
    1640                 1645                 1650             


Leu Val  Glu Ser Asp Ser Asp  Ile Asn Ala Asn Lys  Glu Glu Leu 
    1655                 1660                 1665             


Leu Arg  Val Leu Asp Trp Val  Pro Lys Leu Trp Tyr  His Leu His 
    1670                 1675                 1680             


Thr Phe  Leu Glu Lys His Ser  Thr Ser Asp Phe Leu  Ile Gly Pro 
    1685                 1690                 1695             


Cys Phe  Phe Leu Ser Cys Pro  Ile Gly Ile Glu Asp  Phe Arg Thr 
    1700                 1705                 1710             


Trp Phe  Ile Asp Leu Trp Asn  Asn Ser Ile Ile Pro  Tyr Leu Gln 
    1715                 1720                 1725             


Glu Gly  Ala Lys Asp Gly Ile  Lys Val His Gly Gln  Lys Ala Ala 
    1730                 1735                 1740             


Trp Glu  Asp Pro Val Glu Trp  Val Arg Asp Thr Leu  Pro Trp Pro 
    1745                 1750                 1755             


Ser Ala  Gln Gln Asp Gln Ser  Lys Leu Tyr His Leu  Pro Pro Pro 
    1760                 1765                 1770             


Thr Val  Gly Pro His Ser Ile  Ala Ser Pro Pro Glu  Asp Arg Thr 
    1775                 1780                 1785             


Val Lys  Asp Ser Thr Pro Ser  Ser Leu Asp Ser Asp  Pro Leu Met 
    1790                 1795                 1800             


Ala Met  Leu Leu Lys Leu Gln  Glu Ala Ala Asn Tyr  Ile Glu Ser 
    1805                 1810                 1815             


Pro Asp  Arg Glu Thr Ile Leu  Asp Pro Asn Leu Gln  Ala Thr Leu 
    1820                 1825                 1830             


<210>  6853
<211>  839
<212>  DNA
<213>  Homosapiens

<400>  6853
ttcaggcgcg cctctcctct ctcggacttt cacaaccacc agcgacatca atctctcgct     60

tcctgctcca cttctcggcg cccacatctc caactggctc aggctcccca tgtccccagc    120

cggtacggag ctgcggtcag cggattgtgc ggctgagcca tcctcgtgac ggtcccgcct    180

cactcaccct ccgtcacctc cagcacctta atctgttctt cagcagccgc ccgcacctcc    240

tgtactgggg ataggatccc ggtgagcgta tccactaacg cttcctttaa tccttgtgcc    300

actggacccg gcagcccgga ggccgcacca gctgccgccg ccgccgccat cttttctccc    360

ctcagcccgc cagccccgcg gccgggaccc gccaccgaat gacggccccc gcgcgcggcc    420

aatccgcgaa gccgcgcctg cgcaccagag gcgggcggga gcgggcggag ggcggggaat    480

gaatctaagc ctccagagac agcgcctcct gctgcctgaa cgagaactgc acctttctct    540

gcaaggatct ctggatttgt gtgaaaactg agccccagac aggttaaggg gctttcctaa    600

agttgcacaa atggcttcta ctcaccagag gatctgagtc cagagaactt ggggtgctgt    660

ctttgactgt cctatcctcg ggagattctt caaaacatcc cattttcccc aggaagttct    720

ccttgattcc atgggagtag ggagaccaca agctgtgcag attcacgtcc ctcctgggaa    780

gaggtttacc tggtccataa gcactaacct gccatggtct actctgctcc agtgccacc     839


<210>  6854
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  6854

Met Gly Val Gly Arg Pro Gln Ala Val Gln Ile His Val Pro Pro Gly 
1               5                   10                  15      


Lys Arg Phe Thr Trp Ser Ile Ser Thr Asn Leu Pro Trp Ser Thr Leu 
            20                  25                  30          


Leu Gln Cys 
        35  


<210>  6855
<211>  1809
<212>  DNA
<213>  Homosapiens

<400>  6855
ataaagagaa caagtctcag ccagtagctc agctcagggg agaggctctc agctgagtcc     60

ccactgaaca ttctggggta tagggtctct aaatcacctc cttcttggga ttgattcctg    120

agctgccaga acccaacaga aggcaagttt cctgctataa gttcctcttt ccttcttgat    180

gaggacggac acttcagagc caaagaggaa acgaatccca tctgttctga gcccccaagc    240

acagttcaag aggacaggct ggggagtgga ggaaggggcg gtgaagagaa aaataagaag    300

actggaacat ccagccacac acggagggca ggaagccacc tgatgagaga gccagggtgt    360

ggcagaagtc gccaaggaat ccttctgttc ccgacacacg cctacagcac tcgctcaaga    420

tggagcctgc tgactctgtc taaggccctg tggcccttgg cataggtttc aggacagcag    480

tcctgtcagg gctgtggacc tcacacctct atgtaatgtg aagggcaccc tctggagttg    540

tgggacttgg cagtagtgtt actgcactgg cctgcaagtc cccatccatt actgccaccc    600

agctcagaca cagctcaccc attcacatac acaaaaatgg acacattgag agggaaaccc    660

acattaaagt agggagaaga tggagggccc tctgacctcc tcccatcagg cacgtgtgcc    720

tcctctactc agtgcctgca tccacctctg tatgggtacc catcctctat tcccctccca    780

ctccaatgga tgccagggat ggaaggacag atggctgtga aacttatctt cttatttaga    840

ttaaattcca gactttccta tttttagaaa aacaaattcc ttttgtattt ccaagtggta    900

aaaatggccc gagctgtcat ctaggacagt cagcagccaa ctcaaagttg tctgcagtgt    960

catgatttgg atattaccct ggcgagacta cttctagtgt caagcgggtg atcagtctag   1020

gtgccaaatt ttaagagggt cattgacgtc ctgagagctt ccagaggagg gtgaccagga   1080

caatgaaagg ttcgaaaaac tgggtcattg aaaaaagtac tgaaataagc tagggacttt   1140

ttctttttct ttttggtcta gagaatattt gagctatatt aagaacatgt tgaaatattt   1200

ggatgaagag ttacaccctt attctatttt tcccagatga cagaatttga atcaataggt   1260

agaagttaca gcgaaacaga tttcagttga atatttagaa actttcttat aacttaattc   1320

tgtatgatat ggaataagct tcccatcact gtgcctatgc aagccaagga tgaaagactg   1380

tctgtcaggg atactgtaga taagattatt gtactagata ggaacatgga ctagtctaaa   1440

attactgaga agctttagaa aaatgtggct ttctgggtag cagagattct gcattggtaa   1500

gtctgaggct tagaatttgt atttccaaaa aaccccatca gctataaaac tctcagaaga   1560

aaacgtaggg gaaaagctgc atggcgttag attttgcagt gatttcttag atatgacact   1620

caaagcatag ccaacaaaag aaaaaaacag ataaaatgga tttcatctaa ataaaaagct   1680

tttgtgcatc aaaggataca tctacagaat gaaaaggaaa cccaatacac agaatgaaag   1740

aaaatatctc caaatcatac atgtgataaa aggttcatat ctagcatata taaagaactc   1800

ttaacactc                                                           1809


<210>  6856
<211>  54
<212>  PRT
<213>  Homosapiens

<400>  6856

Met Arg Thr Asp Thr Ser Glu Pro Lys Arg Lys Arg Ile Pro Ser Val 
1               5                   10                  15      


Leu Ser Pro Gln Ala Gln Phe Lys Arg Thr Gly Trp Gly Val Glu Glu 
            20                  25                  30          


Gly Ala Val Lys Arg Lys Ile Arg Arg Leu Glu His Pro Ala Thr His 
        35                  40                  45              


Gly Gly Gln Glu Ala Thr 
    50                  


<210>  6857
<211>  2035
<212>  DNA
<213>  Homosapiens

<400>  6857
gtgaattaga cattcttccc ccctccaatt tacaagtgaa gaaattggaa ctcagattaa     60

ctggcttggg aggatcatat aactcaaagt ggccccacca gaacagaacc caggcctctg    120

cctctgacat tctgggcacg ttccagtgca cctactgcct caccatgtgc tccttgaagc    180

ctttccctct gtgtgcagcc cttgtgtccc tgaagcctgt gagcatgaca ggggcaggga    240

tcacaggcct tccactggag taggagtttc ccaaggacag agactctgtc ttctctctct    300

ctgtttcccc tcgacaccta gcaatgtagg ttctcaggcc atgctgtcga ctgaccaatg    360

aatcattgtt agagaccccc tcctggaatg cccttacatg acctctccat cttccaggat    420

agagtcttgc tttggggagc cacaaagtgg ccacagtcag gaattctggt ccaagggcag    480

aaggagcaac ccaagcctct gtgaatacaa gtccttgttt gactccagct caaaggctga    540

gctgtcccag gatgttcatg aggggccagc tctggcctct gggctatcag atgtctctgg    600

ccaggcagta aaaggccatt cactgcagct gaagaaaggc cagcaggcca ggcagaggga    660

cttacctacg gaagtgttca gggttggggg tccaaagatg ctgaaggact gaatggtggt    720

catctatata tcagtgtgac gatggaacaa gcacaggaaa aggcataaaa gtatagattt    780

gcaaagcagg ccagaggaaa gagtcaggcc catagagacc gaaagcacat agctacattg    840

gaggcagatc gacactcact gaatatgcag ggcaggatca cggagagaca aggtaggaga    900

ggctgacacg ggggcatgtg cggtagaaaa acagagtcag cacgttcgtg atgtgcacac    960

caagcagtgg aaatgagaga cagacagata ctgtgtgaga cccatccaaa cgtgtgtgag   1020

aggtggctgg atacaaagag gctgtgtgtg cacaagatcg actgtttgag gacacaggcc   1080

cgccgatgtg cagggggtgt gcggcaacca gacaggcaca gagagtgtct gagaggtgga   1140

gggacccctc cagagaaaca agagtgacct tgtgctcagc ctgagggttg gggagtgacc   1200

cagagcaggg cgagtatatt ctcaccagcc tacccccctt ctcctttggc cagctcctac   1260

taaaaggggt ctgtgtcgta ccttgtctct ttcttgtggg gcatctccag cttgggagac   1320

aggaacaaag ctctgaccta gtccctgccc tctttgactg ctcaccctct tccagcccct   1380

ctacccagcc tcaatctctc attcttcctc tactttgaag tctggcttct gtcttggccc   1440

ctgtgggttt gatgacaaag ggcagttcag gaatgacact atctacacat acatggccat   1500

atggacaatt tcaggtggtg ggacttgcag cagctggggt tcccaggact gctgacattc   1560

tgctgagtgt tattagaaga tcagggacag agcttatcat ctggctgtca ctgccccttt   1620

ccaagccaca gcgagcctcc acagaggggc cctgggggat agccagctgc cctgtgctca   1680

tgctggagtg aactttcctc tgatcttccc tgttttctgg atttagccag ggaaaataca   1740

agggagctcc ttgctccctg tgtgaggttc caactgagag atcccaccct tcccagctct   1800

gatcagatac ccctgaagtt tggaaggcaa cagctataca atctctctct ctcttttttt   1860

tttttccagc ctgggtgaca gagcgagact ccttctcaaa aaagaaaaaa gaaagtaatg   1920

gcagtgctcg ctttggcagc acatatacta aaattggaac aatacagaga agattagcat   1980

gtgcaaggat gacacccaaa tctgtgaagc cttctatatt taaaatatat atatt        2035


<210>  6858
<211>  104
<212>  PRT
<213>  Homosapiens

<400>  6858

Met Thr Ser Pro Ser Ser Arg Ile Glu Ser Cys Phe Gly Glu Pro Gln 
1               5                   10                  15      


Ser Gly His Ser Gln Glu Phe Trp Ser Lys Gly Arg Arg Ser Asn Pro 
            20                  25                  30          


Ser Leu Cys Glu Tyr Lys Ser Leu Phe Asp Ser Ser Ser Lys Ala Glu 
        35                  40                  45              


Leu Ser Gln Asp Val His Glu Gly Pro Ala Leu Ala Ser Gly Leu Ser 
    50                  55                  60                  


Asp Val Ser Gly Gln Ala Val Lys Gly His Ser Leu Gln Leu Lys Lys 
65                  70                  75                  80  


Gly Gln Gln Ala Arg Gln Arg Asp Leu Pro Thr Glu Val Phe Arg Val 
                85                  90                  95      


Gly Gly Pro Lys Met Leu Lys Asp 
            100                 


<210>  6859
<211>  5441
<212>  DNA
<213>  Homosapiens

<400>  6859
ggagaaaagg gagcggaggg caggcgaggg ttaggtttcc gaccctccgc gtggcccaca     60

gctcatacct tttcgggtgt ccccgggtgt caggcgagag cggtcctggg gggcgctggg    120

tgcccacccg gtgaatggcc gcctgagccg gggaagatgc ttcatctgcc cctgcccaga    180

tccggaagaa cggtgaattt cccccgcagc tgggatgaaa gcagctccat cagtagtgga    240

ctcagcgatg cctcagacaa tctcagttca gaagaattca atgccagctc ctcactcaac    300

tccctcccaa gtactcccac tgcttctcgc aggaactcaa caatagtgct acgcacagac    360

tcagagaagc gctcactggc agaaagtggg ctgagctggt ttagtgaatc agaggagaaa    420

gcccctaaaa aactggagta cgacagtggt agcctgaaga tggaacctgg gacttctaag    480

tggcggaggg agcggcctga gagctgtgat gattcatcca agggtggaga actgaaaaag    540

cccatcagcc tgggccaccc tggttccctg aagaagggca agaccccacc tgtggctgta    600

acttccccca tcactcacac agcccagagt gccctcaaag tcgcaggcaa acctgagggc    660

aaagctacag acaagggtaa gcttgcagtg aagaatactg ggctccaacg ctcctcctct    720

gatgctggtc gggaccgcct gagtgatgct aagaagcccc cctcgggcat tgctcgcccc    780

tccacttcgg gatcctttgg ctacaagaag cctcctcctg ccacaggcac agccactgtc    840

atgcaaactg gtggttcagc cactctcagc aagatccaga agtcctcagg catccctgtc    900

aagccagtaa atgggcgcaa gactagctta gatgtttcca acagtgcaga gccaggattc    960

ctggctcctg gagcccgttc taacatccag taccgcagcc tgccccggcc agccaagtca   1020

agttctatga gcgtgaccgg cgggcggggt ggacctcgcc ctgtgagcag cagcattgac   1080

cccagtctcc tcagcaccaa gcagggaggc cttacgcctt ccagactgaa ggagcctacc   1140

aaggtagcca gtgggcggac cactccagcc cctgtcaatc agacagatcg ggaaaaggag   1200

aaggccaaag ccaaggcagt ggccttggac tcagacaaca tctccttgaa gagtattggc   1260

tccccagaaa gtactcccaa gaaccaagca agccacccca cagccaccaa gctggcagag   1320

ctgccaccaa cccctctcag ggccacagcg aagagctttg tcaaaccacc ctcactagcc   1380

aatcttgaca aggtcaactc caacagtctg gatctaccat catccagtga taccacccat   1440

gcttcaaagg tcccagatct gcatgctaca agctcagcat ctgggggccc tctcccttcc   1500

tgcttcaccc ccagtccggc acccatcctc aatattaact cagccagctt ctcccagggc   1560

ctggagctaa tgagtggttt cagtgtgcca aaagagaccc gcatgtaccc caaactctca   1620

ggcctgcaca ggagcatgga gtccctccag atgccaatga gcctccccag tgccttcccc   1680

agcagtactc ccgtccccac cccacctgct ccccctgctg ctcccacaga agaagagacg   1740

gaagagctga cttggagtgg aagccccaga gctgggcaac tggacagtaa tcagcgggat   1800

cggaacactc ttcccaagaa agggctcagg taccagcttc agtcccagga ggagaccaag   1860

gagaggcgac attcccatac cattggtggg ctgcctgaat ccgatgacca gtcagagctg   1920

ccttctcccc ctgcacttcc catgtctctg agtgcaaagg gccaacttac caacatagtg   1980

agtcccactg cggccaccac gccaagaatc acccgctcca acagcatccc cacccacgag   2040

gcggccttcg agctgtacag cggctcccaa atggggagca ccctgtccct ggccgagaga   2100

cccaagggaa tgattcggtc aggatccttc cgagacccca cggacgatgt tcacggctca   2160

gtgctgtccc tggcctccag tgcctcctcc acctactcct cagctgagga gaggatgcaa   2220

tctgagcaaa tccggaagct tcgtagggaa ctggaatcat cccaggaaaa agtggccacc   2280

ttgacgtctc agctttctgc caatgctaat ctggtggctg cttttgagca gagcctggtg   2340

aatatgacat cccgcctgcg acacctggca gagacggccg aggagaagga cactgagctg   2400

ctggatttgc gagaaaccat agactttctg aagaaaaaga actctgaggc ccaggcagtc   2460

attcagggag cccttaatgc ctcagaaacc acacccaaag aacttcggat caagagacaa   2520

aactcctcag atagcatctc aagcctcaac agcatcacta gccattccag catcggcagc   2580

agcaaggatg ctgatgcgaa aaagaagaaa aaaaagagtt ggcttcgaag ttccttcaac   2640

aaagcgttca gtataaaaaa ggggcccaag tcagcttcct catactcgga tatagaggag   2700

attgctacac ccgactcttc agccccctca tcccccaaac tacagcatgg ttctacagag   2760

actgcttcac cctccatcaa gtcctccacc tcgtcctccg tgggcactga tgtcaccgag   2820

ggccctgctc acccagcccc ccacactagg ctgttccatg caaatgagga ggaggagcca   2880

gagaagaagg aggtatcgga gctgcgctct gagctatggg agaaggaaat gaagcttaca   2940

gacatccgct tggaggccct caactctgcc caccaactgg atcagcttcg ggagaccatg   3000

cacaacatgc agttggaggt ggacctgctg aaagcagaga atgaccgact gaaggtagcc   3060

ccaggcccct catcaggctc cactccaggg caggtccctg gatcatctgc attatcttcc   3120

ccacgccgct ccctaggcct ggcactcacc cattccttcg gccccagtct tgcagacaca   3180

gacctgtcac ccatggatgg catcagtact tgtggtccaa aggaggaagt gaccctccgg   3240

gtggtggtga ggatgccccc gcagcacatc atcaaagggg acttgaagca gcaggaattc   3300

ttcctgggct gtagcaaggt cagtggaaaa gttgactgga agatgctgga tgaagctgtt   3360

ttccaagtgt tcaaggacta tatttctaaa atggacccag cctctaccct gggactaagc   3420

actgagtcca tccatggcta cagcatcagc cacgtgaaac gagtgttgga tgcagagccc   3480

cccgagatgc ctccttgccg tcgaggtgtc aataacatat cagtctccct caaaggtctg   3540

aaggagaaat gcgtcgacag cctggtgttc gagacgctga tccccaagcc gatgatgcag   3600

cactacataa gcctcctgct gaagcaccgg cgcctcgtcc tctcgggccc cagcggcacg   3660

ggcaagacct acctgaccaa tcgcttggcc gagtacctgg tggagcgctc tggccgtgag   3720

gtcacagagg gcatcgtcag caccttcaac atgcaccagc agtcttgcaa ggatctgcaa   3780

ctgtatcttt ccaacctagc caaccagata gaccgggaaa caggaattgg ggatgtgccc   3840

ctggtgattc tattggatga cctgagtgaa gcaggctcca tcagtgagtt ggtcaatggg   3900

gccctcacct gcaagtatca taaatgtccc tatattatag gtaccaccaa tcagcctgta   3960

aaaatgacac ccaaccatgg cttgcacttg agcttcagga tgttgacctt ctccaacaac   4020

gtggagccag ccaatggctt cctggttcgt tacctgagga ggaagctggt agagtcagac   4080

agcgacatca atgccaacaa ggaagagctg cttcgggtgc tcgactgggt acccaagctg   4140

tggtatcatc tccacacctt ccttgagaag cacagcacct cagacttcct catcggccct   4200

tgcttctttc tgtcgtgtcc cattggcatt gaggacttcc ggacctggtt cattgacctg   4260

tggaacaact ctatcattcc ctatctacag gaaggagcca aggatgggat aaaggtccat   4320

ggacagaaag ctgcttggga ggacccagtg gaatgggtcc gggacacact tccctggcca   4380

tcagcccaac aagaccaatc aaagctgtac cacctgcccc cacccaccgt gggccctcac   4440

agcattgcct cacctcccga ggataggaca gtcaaagaca gcaccccaag ttctctggac   4500

tcagatcctc tgatggccat gctgctgaaa cttcaagaag ctgccaacta cattgagtct   4560

ccagatcgag aaaccatcct ggaccccaac cttcaggcaa cactttaagg gttcggcaat   4620

cactgtcacc cccggacagc agaacgctgg catcagctat cttagctcct cctctcccct   4680

ctcctctttc agagcactgg ctctccagcc ccaggaggag aacaggaggg aggaggagat   4740

gaaagaggag ggacaggttc ttggtgctgt acctttgaga acttcctagg aaggaatggt   4800

ggggtggcgt ttgggaactt gtgcccccta aacacattta ctggcctcct ctaatgactt   4860

tggggaaaag atgattctgg gtctttccct tgacttcttg tttcaattac aaactcctgg   4920

gctttctggg gaggggttca gaaaacatca aaacactgca gcagttccta aatgattctc   4980

acaagcaacc ctgagagaga cagtcttgtg agggagatct gggggaggca ggaagctcct   5040

cagattttct cacagaccct tcccaattcc atcaccactg ccaacaactc ctcccccaga   5100

gatctggctg gagcccagaa aaagaagcat gtggtttaaa aaatgtttaa atcaatctgt   5160

aaaaggtaaa aatgaaaaac aaaaacaagc aaacaaacaa aaaacaatgg aaaagatgaa   5220

gctggagaga gaggaaccag ttgccaaggt agagagctgc ccgctcctgc cctctggatg   5280

acatagggga catcaacaag acggctgcca acctgagaag tcaccaaacc acaaaaataa   5340

ccttacagcc ttcagggaaa gactaccagc tctgtctttc taccctctaa tttaacaatg   5400

cataagagtc aataaaccct acttttttat ttttggtttt t                       5441


<210>  6860
<211>  1483
<212>  PRT
<213>  Homosapiens

<400>  6860

Met Leu His Leu Pro Leu Pro Arg Ser Gly Arg Thr Val Asn Phe Pro 
1               5                   10                  15      


Arg Ser Trp Asp Glu Ser Ser Ser Ile Ser Ser Gly Leu Ser Asp Ala 
            20                  25                  30          


Ser Asp Asn Leu Ser Ser Glu Glu Phe Asn Ala Ser Ser Ser Leu Asn 
        35                  40                  45              


Ser Leu Pro Ser Thr Pro Thr Ala Ser Arg Arg Asn Ser Thr Ile Val 
    50                  55                  60                  


Leu Arg Thr Asp Ser Glu Lys Arg Ser Leu Ala Glu Ser Gly Leu Ser 
65                  70                  75                  80  


Trp Phe Ser Glu Ser Glu Glu Lys Ala Pro Lys Lys Leu Glu Tyr Asp 
                85                  90                  95      


Ser Gly Ser Leu Lys Met Glu Pro Gly Thr Ser Lys Trp Arg Arg Glu 
            100                 105                 110         


Arg Pro Glu Ser Cys Asp Asp Ser Ser Lys Gly Gly Glu Leu Lys Lys 
        115                 120                 125             


Pro Ile Ser Leu Gly His Pro Gly Ser Leu Lys Lys Gly Lys Thr Pro 
    130                 135                 140                 


Pro Val Ala Val Thr Ser Pro Ile Thr His Thr Ala Gln Ser Ala Leu 
145                 150                 155                 160 


Lys Val Ala Gly Lys Pro Glu Gly Lys Ala Thr Asp Lys Gly Lys Leu 
                165                 170                 175     


Ala Val Lys Asn Thr Gly Leu Gln Arg Ser Ser Ser Asp Ala Gly Arg 
            180                 185                 190         


Asp Arg Leu Ser Asp Ala Lys Lys Pro Pro Ser Gly Ile Ala Arg Pro 
        195                 200                 205             


Ser Thr Ser Gly Ser Phe Gly Tyr Lys Lys Pro Pro Pro Ala Thr Gly 
    210                 215                 220                 


Thr Ala Thr Val Met Gln Thr Gly Gly Ser Ala Thr Leu Ser Lys Ile 
225                 230                 235                 240 


Gln Lys Ser Ser Gly Ile Pro Val Lys Pro Val Asn Gly Arg Lys Thr 
                245                 250                 255     


Ser Leu Asp Val Ser Asn Ser Ala Glu Pro Gly Phe Leu Ala Pro Gly 
            260                 265                 270         


Ala Arg Ser Asn Ile Gln Tyr Arg Ser Leu Pro Arg Pro Ala Lys Ser 
        275                 280                 285             


Ser Ser Met Ser Val Thr Gly Gly Arg Gly Gly Pro Arg Pro Val Ser 
    290                 295                 300                 


Ser Ser Ile Asp Pro Ser Leu Leu Ser Thr Lys Gln Gly Gly Leu Thr 
305                 310                 315                 320 


Pro Ser Arg Leu Lys Glu Pro Thr Lys Val Ala Ser Gly Arg Thr Thr 
                325                 330                 335     


Pro Ala Pro Val Asn Gln Thr Asp Arg Glu Lys Glu Lys Ala Lys Ala 
            340                 345                 350         


Lys Ala Val Ala Leu Asp Ser Asp Asn Ile Ser Leu Lys Ser Ile Gly 
        355                 360                 365             


Ser Pro Glu Ser Thr Pro Lys Asn Gln Ala Ser His Pro Thr Ala Thr 
    370                 375                 380                 


Lys Leu Ala Glu Leu Pro Pro Thr Pro Leu Arg Ala Thr Ala Lys Ser 
385                 390                 395                 400 


Phe Val Lys Pro Pro Ser Leu Ala Asn Leu Asp Lys Val Asn Ser Asn 
                405                 410                 415     


Ser Leu Asp Leu Pro Ser Ser Ser Asp Thr Thr His Ala Ser Lys Val 
            420                 425                 430         


Pro Asp Leu His Ala Thr Ser Ser Ala Ser Gly Gly Pro Leu Pro Ser 
        435                 440                 445             


Cys Phe Thr Pro Ser Pro Ala Pro Ile Leu Asn Ile Asn Ser Ala Ser 
    450                 455                 460                 


Phe Ser Gln Gly Leu Glu Leu Met Ser Gly Phe Ser Val Pro Lys Glu 
465                 470                 475                 480 


Thr Arg Met Tyr Pro Lys Leu Ser Gly Leu His Arg Ser Met Glu Ser 
                485                 490                 495     


Leu Gln Met Pro Met Ser Leu Pro Ser Ala Phe Pro Ser Ser Thr Pro 
            500                 505                 510         


Val Pro Thr Pro Pro Ala Pro Pro Ala Ala Pro Thr Glu Glu Glu Thr 
        515                 520                 525             


Glu Glu Leu Thr Trp Ser Gly Ser Pro Arg Ala Gly Gln Leu Asp Ser 
    530                 535                 540                 


Asn Gln Arg Asp Arg Asn Thr Leu Pro Lys Lys Gly Leu Arg Tyr Gln 
545                 550                 555                 560 


Leu Gln Ser Gln Glu Glu Thr Lys Glu Arg Arg His Ser His Thr Ile 
                565                 570                 575     


Gly Gly Leu Pro Glu Ser Asp Asp Gln Ser Glu Leu Pro Ser Pro Pro 
            580                 585                 590         


Ala Leu Pro Met Ser Leu Ser Ala Lys Gly Gln Leu Thr Asn Ile Val 
        595                 600                 605             


Ser Pro Thr Ala Ala Thr Thr Pro Arg Ile Thr Arg Ser Asn Ser Ile 
    610                 615                 620                 


Pro Thr His Glu Ala Ala Phe Glu Leu Tyr Ser Gly Ser Gln Met Gly 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Ala Glu Arg Pro Lys Gly Met Ile Arg Ser Gly 
                645                 650                 655     


Ser Phe Arg Asp Pro Thr Asp Asp Val His Gly Ser Val Leu Ser Leu 
            660                 665                 670         


Ala Ser Ser Ala Ser Ser Thr Tyr Ser Ser Ala Glu Glu Arg Met Gln 
        675                 680                 685             


Ser Glu Gln Ile Arg Lys Leu Arg Arg Glu Leu Glu Ser Ser Gln Glu 
    690                 695                 700                 


Lys Val Ala Thr Leu Thr Ser Gln Leu Ser Ala Asn Ala Asn Leu Val 
705                 710                 715                 720 


Ala Ala Phe Glu Gln Ser Leu Val Asn Met Thr Ser Arg Leu Arg His 
                725                 730                 735     


Leu Ala Glu Thr Ala Glu Glu Lys Asp Thr Glu Leu Leu Asp Leu Arg 
            740                 745                 750         


Glu Thr Ile Asp Phe Leu Lys Lys Lys Asn Ser Glu Ala Gln Ala Val 
        755                 760                 765             


Ile Gln Gly Ala Leu Asn Ala Ser Glu Thr Thr Pro Lys Glu Leu Arg 
    770                 775                 780                 


Ile Lys Arg Gln Asn Ser Ser Asp Ser Ile Ser Ser Leu Asn Ser Ile 
785                 790                 795                 800 


Thr Ser His Ser Ser Ile Gly Ser Ser Lys Asp Ala Asp Ala Lys Lys 
                805                 810                 815     


Lys Lys Lys Lys Ser Trp Leu Arg Ser Ser Phe Asn Lys Ala Phe Ser 
            820                 825                 830         


Ile Lys Lys Gly Pro Lys Ser Ala Ser Ser Tyr Ser Asp Ile Glu Glu 
        835                 840                 845             


Ile Ala Thr Pro Asp Ser Ser Ala Pro Ser Ser Pro Lys Leu Gln His 
    850                 855                 860                 


Gly Ser Thr Glu Thr Ala Ser Pro Ser Ile Lys Ser Ser Thr Ser Ser 
865                 870                 875                 880 


Ser Val Gly Thr Asp Val Thr Glu Gly Pro Ala His Pro Ala Pro His 
                885                 890                 895     


Thr Arg Leu Phe His Ala Asn Glu Glu Glu Glu Pro Glu Lys Lys Glu 
            900                 905                 910         


Val Ser Glu Leu Arg Ser Glu Leu Trp Glu Lys Glu Met Lys Leu Thr 
        915                 920                 925             


Asp Ile Arg Leu Glu Ala Leu Asn Ser Ala His Gln Leu Asp Gln Leu 
    930                 935                 940                 


Arg Glu Thr Met His Asn Met Gln Leu Glu Val Asp Leu Leu Lys Ala 
945                 950                 955                 960 


Glu Asn Asp Arg Leu Lys Val Ala Pro Gly Pro Ser Ser Gly Ser Thr 
                965                 970                 975     


Pro Gly Gln Val Pro Gly Ser Ser Ala Leu Ser Ser Pro Arg Arg Ser 
            980                 985                 990         


Leu Gly Leu Ala Leu Thr His Ser  Phe Gly Pro Ser Leu  Ala Asp Thr 
        995                 1000                 1005             


Asp Leu  Ser Pro Met Asp Gly  Ile Ser Thr Cys Gly  Pro Lys Glu 
    1010                 1015                 1020             


Glu Val  Thr Leu Arg Val Val  Val Arg Met Pro Pro  Gln His Ile 
    1025                 1030                 1035             


Ile Lys  Gly Asp Leu Lys Gln  Gln Glu Phe Phe Leu  Gly Cys Ser 
    1040                 1045                 1050             


Lys Val  Ser Gly Lys Val Asp  Trp Lys Met Leu Asp  Glu Ala Val 
    1055                 1060                 1065             


Phe Gln  Val Phe Lys Asp Tyr  Ile Ser Lys Met Asp  Pro Ala Ser 
    1070                 1075                 1080             


Thr Leu  Gly Leu Ser Thr Glu  Ser Ile His Gly Tyr  Ser Ile Ser 
    1085                 1090                 1095             


His Val  Lys Arg Val Leu Asp  Ala Glu Pro Pro Glu  Met Pro Pro 
    1100                 1105                 1110             


Cys Arg  Arg Gly Val Asn Asn  Ile Ser Val Ser Leu  Lys Gly Leu 
    1115                 1120                 1125             


Lys Glu  Lys Cys Val Asp Ser  Leu Val Phe Glu Thr  Leu Ile Pro 
    1130                 1135                 1140             


Lys Pro  Met Met Gln His Tyr  Ile Ser Leu Leu Leu  Lys His Arg 
    1145                 1150                 1155             


Arg Leu  Val Leu Ser Gly Pro  Ser Gly Thr Gly Lys  Thr Tyr Leu 
    1160                 1165                 1170             


Thr Asn  Arg Leu Ala Glu Tyr  Leu Val Glu Arg Ser  Gly Arg Glu 
    1175                 1180                 1185             


Val Thr  Glu Gly Ile Val Ser  Thr Phe Asn Met His  Gln Gln Ser 
    1190                 1195                 1200             


Cys Lys  Asp Leu Gln Leu Tyr  Leu Ser Asn Leu Ala  Asn Gln Ile 
    1205                 1210                 1215             


Asp Arg  Glu Thr Gly Ile Gly  Asp Val Pro Leu Val  Ile Leu Leu 
    1220                 1225                 1230             


Asp Asp  Leu Ser Glu Ala Gly  Ser Ile Ser Glu Leu  Val Asn Gly 
    1235                 1240                 1245             


Ala Leu  Thr Cys Lys Tyr His  Lys Cys Pro Tyr Ile  Ile Gly Thr 
    1250                 1255                 1260             


Thr Asn  Gln Pro Val Lys Met  Thr Pro Asn His Gly  Leu His Leu 
    1265                 1270                 1275             


Ser Phe  Arg Met Leu Thr Phe  Ser Asn Asn Val Glu  Pro Ala Asn 
    1280                 1285                 1290             


Gly Phe  Leu Val Arg Tyr Leu  Arg Arg Lys Leu Val  Glu Ser Asp 
    1295                 1300                 1305             


Ser Asp  Ile Asn Ala Asn Lys  Glu Glu Leu Leu Arg  Val Leu Asp 
    1310                 1315                 1320             


Trp Val  Pro Lys Leu Trp Tyr  His Leu His Thr Phe  Leu Glu Lys 
    1325                 1330                 1335             


His Ser  Thr Ser Asp Phe Leu  Ile Gly Pro Cys Phe  Phe Leu Ser 
    1340                 1345                 1350             


Cys Pro  Ile Gly Ile Glu Asp  Phe Arg Thr Trp Phe  Ile Asp Leu 
    1355                 1360                 1365             


Trp Asn  Asn Ser Ile Ile Pro  Tyr Leu Gln Glu Gly  Ala Lys Asp 
    1370                 1375                 1380             


Gly Ile  Lys Val His Gly Gln  Lys Ala Ala Trp Glu  Asp Pro Val 
    1385                 1390                 1395             


Glu Trp  Val Arg Asp Thr Leu  Pro Trp Pro Ser Ala  Gln Gln Asp 
    1400                 1405                 1410             


Gln Ser  Lys Leu Tyr His Leu  Pro Pro Pro Thr Val  Gly Pro His 
    1415                 1420                 1425             


Ser Ile  Ala Ser Pro Pro Glu  Asp Arg Thr Val Lys  Asp Ser Thr 
    1430                 1435                 1440             


Pro Ser  Ser Leu Asp Ser Asp  Pro Leu Met Ala Met  Leu Leu Lys 
    1445                 1450                 1455             


Leu Gln  Glu Ala Ala Asn Tyr  Ile Glu Ser Pro Asp  Arg Glu Thr 
    1460                 1465                 1470             


Ile Leu  Asp Pro Asn Leu Gln  Ala Thr Leu 
    1475                 1480             


<210>  6861
<211>  2800
<212>  DNA
<213>  Homosapiens

<400>  6861
ggggaatcta gatctagtaa gacttcttca aaatcctgat ttccaaggcc gatccagctg     60

cttattccca agtgctgacc cacagccttc ttttattcca ggatctgcaa ctgtatcttt    120

ccaacctagc caaccagata gaccgggaaa caggaattgg ggatgtgccc ctggtgattc    180

tattggatga cctgagtgaa gcaggctcca tcagtgagtt ggtcaatggg gccctcacct    240

gcaagtatca taaatggtaa gtaagctggg atcaagacaa aattcatcga agtgggagga    300

gggagaaccc agtccaggac aacctatgag ttgtgtgcat gtggcagaaa gcaagtgtga    360

aggcaagtct aagtgaatct ttttcccctt tctccctaca gtccctatat tataggtacc    420

accaatcagc ctgtaaaaat gacacccaac catggcttgc acttgagctt caggtaagac    480

ctctagctct ggatgaacct tctgacccta cccaagagtc ttcaatcctg gactctggcc    540

aggaggcagt agataggaga aggaaagaga agtatccaga gctttttggg ctggaaatag    600

aaagtagatg tatttgtcat gtcagttaca aggtggagga ggacacttga ggagagaaaa    660

ggcctgctaa gctaagagag agccaggtag gttgctctaa gcagaattag gattctctgc    720

ccgcacacgc tgatctgggt cagtgatgtc agaaggttat ccgaagaggg ctaccaattt    780

gagaatcagc tctaccaccc cagggctgct gctctgagtt ccgatgtccc cactattact    840

tgaaaagaaa ccaagtaggc attagtgaga agcaggcaga aggagggaca gactggcagg    900

ggctgaaccc tgacaatgtc cccattgcca ctctgacccc actttcccca tccttggtgg    960

caggatgttg accttctcca acaacgtgga gccagccaat ggcttcctgg ttcgttacct   1020

gaggaggaag ctggtagagt cagacagcga catcaatgcc aacaaggaag agctgcttcg   1080

ggtgctcgac tgggtaccca agctgtggta tcatctccac accttccttg agaagcacag   1140

cacctcagac ttcctcatcg gtactggggt ccagcttccc ccgggggtca ggaggtggct   1200

tcccttttcc actgtaccac ctggagggat gctcccttct cttcctggag tcttcggcat   1260

gtaaaggagc tgcaagcctt gtggcttcag acttagaacc acttaacgag ccttcccaac   1320

acagttagca ccacttcaat caccagaaag ctaacccctc tccttgtttt tttcccacaa   1380

ttaacagaaa aaaggaggca catatgtagg aaggaattaa acagctttcc tcactccctt   1440

atctcacttc taccttgtga agcaggactt atgagattgc catctaggca gtcagcaccc   1500

actagtcttg acaactctaa atttccttta atcctttgac tgtcagaccc ctctgcctgg   1560

tactaaggag taaaagaggc acacaaccgg gaagatctag gttcccagcc atcttcatgg   1620

ccccatcctc ttccctaggc ccttgcttct ttctgtcgtg tcccattggc attgaggact   1680

tccggacctg gttcattgac ctgtggaaca actctatcat tccctatcta caggaaggag   1740

ccaaggatgg gataaaggtc catggacaga aagctgcttg ggaggaccca gtggaatggg   1800

tccgggacac acttccctgg ccatcagccc aacaagacag caccccaagt tctctggact   1860

cagatcctct gatggccatg ctgctgaaac ttcaagaagc tgccaactac attgagtctc   1920

cagatcgaga aaccatcctg gaccccaacc ttcaggcaac actttaaggg ttcggcaatc   1980

actgtcaccc ccggacagca gaacgctggc atcagctatc ttagctcctc ctctcccctc   2040

tcctctttca gagcactggc tctccagccc caggaggaga acaggaggga ggaggagatg   2100

aaagaggagg gacaggttct tggtgctgta cctttgagaa cttcctagga aggaatggtg   2160

gggtggcgtt tgggaacttg tgccccctaa acacatttac tggcctcctc taatgacttt   2220

ggggaaaaga tgattctggg tctttccctt gacttcttgt ttcaattaca aactcctggg   2280

ctttctgggg aggggttcag aaaacatcaa aacactgcag cagttcctaa atgattctca   2340

caagcaaccc tgagagagac agtcttgtga gggagatctg ggggaggcag gaagctcctc   2400

agattttctc acagaccctt cccaattcca tcaccactgc caacaactcc tcccccagag   2460

atctggctgg agcccagaaa aagaagcatg tggtttaaaa aatgtttaaa tcaatctgta   2520

aaaggtaaaa atgaaaaaca aaaacaagca aacaaacaaa aaacaatgga aaagatgaag   2580

ctggagagag aggaaccagt tgccaaggta gagagctgcc cgctcctgcc ctctggatga   2640

cataggggac atcaacaaga cggctgccaa cctgagaagt caccaaacca caaaaataac   2700

cttacagcct tcagggaaag actaccagct ctgtctttct accctctaat ttaacaatgc   2760

ataagagtca ataaacccta cttttttatt tttggttttt                         2800


<210>  6862
<211>  116
<212>  PRT
<213>  Homosapiens

<400>  6862

Met Ala Pro Ser Ser Ser Leu Gly Pro Cys Phe Phe Leu Ser Cys Pro 
1               5                   10                  15      


Ile Gly Ile Glu Asp Phe Arg Thr Trp Phe Ile Asp Leu Trp Asn Asn 
            20                  25                  30          


Ser Ile Ile Pro Tyr Leu Gln Glu Gly Ala Lys Asp Gly Ile Lys Val 
        35                  40                  45              


His Gly Gln Lys Ala Ala Trp Glu Asp Pro Val Glu Trp Val Arg Asp 
    50                  55                  60                  


Thr Leu Pro Trp Pro Ser Ala Gln Gln Asp Ser Thr Pro Ser Ser Leu 
65                  70                  75                  80  


Asp Ser Asp Pro Leu Met Ala Met Leu Leu Lys Leu Gln Glu Ala Ala 
                85                  90                  95      


Asn Tyr Ile Glu Ser Pro Asp Arg Glu Thr Ile Leu Asp Pro Asn Leu 
            100                 105                 110         


Gln Ala Thr Leu 
        115     


<210>  6863
<211>  296
<212>  DNA
<213>  Homosapiens

<400>  6863
cattgccact ctgaccccac tttccccatc cttggtggca ggatgttgac cttctccaac     60

aacgtggagc cagccaatgg cttcctggtt cgttacctga ggaggaagct ggtagagtca    120

gacagcgaca tcaatgccaa caaggaagag ctgcttcggg tgctcgactg ggtacccaag    180

ctgtggtatc atctccacac cttccttgag aagcacagca cctcagactt cctcatcggt    240

actggggtcc agcttccccc gggggtcagg aggtggcttc ccttttccac tcaccc        296


<210>  6864
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  6864

Met Leu Thr Phe Ser Asn Asn Val Glu Pro Ala Asn Gly Phe Leu Val 
1               5                   10                  15      


Arg Tyr Leu Arg Arg Lys Leu Val Glu Ser Asp Ser Asp Ile Asn Ala 
            20                  25                  30          


Asn Lys Glu Glu Leu Leu Arg Val Leu Asp Trp Val Pro Lys Leu Trp 
        35                  40                  45              


Tyr His Leu His Thr Phe Leu Glu Lys His Ser Thr Ser Asp Phe Leu 
    50                  55                  60                  


Ile Gly Thr Gly Val Gln Leu Pro Pro Gly Val Arg Arg Trp Leu Pro 
65                  70                  75                  80  


Phe Ser Thr 
            


<210>  6865
<211>  566
<212>  DNA
<213>  Homosapiens

<400>  6865
gcacctcctg tactggggat aggatcccgg tgagcgtatc cactaacgct tcctttaatc     60

cttgtgccac tggacccggc agcccggagg ccgcaccagc tgccgccgcc gccgccatct    120

tttctcccct cagcccgcca gccccgcggc cgggacccgc caccgaatga cggcccccgc    180

gcgcggccaa tccgcgaagc cgcgcctgcg caccagaggc gggcgggagc gggcggaggg    240

cggggaatga atctaagcct ccagagacag cgcctcctgc tgcctgaacg agaactgcac    300

ctttctctgc aaggatctct ggatttgtgt gaaaactgag ccccagacag gttaaggggc    360

tttcctaaag ttgcacaaat ggcttctact caccagagga tctgagtcca gagaacttgg    420

ggtgctgtct ttgactgtcc tatcctcggg aggcgcagtg gctcatgcct gtaatcccag    480

catttaggga ggccaagaca ggaagatcac ttgaggtcag aagttcaaga ccagcctggc    540

caacgtggtg aaaccctgtt tctact                                         566


<210>  6866
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  6866

Met Asn Leu Ser Leu Gln Arg Gln Arg Leu Leu Leu Pro Glu Arg Glu 
1               5                   10                  15      


Leu His Leu Ser Leu Gln Gly Ser Leu Asp Leu Cys Glu Asn 
            20                  25                  30  


<210>  6867
<211>  1290
<212>  DNA
<213>  Homosapiens

<400>  6867
gggaatgaat ctaagcctcc agagacagcg cctcctgctg cctgaacgag aactgcacct     60

ttctctgcaa ggatctctgg atttgtgtga aaactgagcc ccagacaggt taaggggctt    120

tcctaaagtt gcacaaaccc tgtcatccat gggagcttac cacgtggatg cagaagcttt    180

tgtgaggggc agcccggacc atcttttgga cttaatatac cgatatgaag attcagatgc    240

atctactcct cggttgggtg gaagagtgat ccaggttggc agccgtcttg ttgatgtccc    300

ctatgtcatc cagagggcag gagcgggcag ctctctacct tggcaactgg ttcctctctc    360

tccagcttca tcttttccat tgttttttgt ttgtttgctt gtttttgttt ttcattttta    420

ccttttacag attgatttaa acatttttta aaccacatgc ttctttttct gggctccagc    480

cagatctctg ggggaggagt tgttggcagt ggtgatggaa ttgggaaggg tctgtgagaa    540

aatctgagga gcttcctgcc tcccccagat ctccctcaca agactgtctc tctcagggtt    600

gcttgtgaga atcatttagg aactgctgca gtgttttgat gttttctgaa cccctcccca    660

gaaagcccag gagtttgtaa ttgaaacaag aagtcaaggg aaagacccag aatcatcttt    720

tccccaaagt cattagagga ggccagtaaa tgtgtttagg gggcacaagt tcccaaacgc    780

caccccacca ttccttccta ggaagttctc aaaggtacag caccaagaac ctgtccctcc    840

tctttcatct cctcctccct cctgttctcc tcctggggct ggagagccag tgctctgaaa    900

gaggagaggg gagaggagga gctaagatag ctgatgccag cgttctgctg tccgggggtg    960

acagtgattg ccgaaccctt aaagtgttgc ctgaaggttg gggtccagga tggtttctcg   1020

atctggagac tcaatgtagt tggcagcttc ttgaagtttc agcagcatgg ccatctaaag   1080

gggggcaaaa agatggattt atgagagttg ggactctggg tcctgcccac agaagggaaa   1140

caacaacaac aaaatcccaa cactttggga ggccaaggtg gaaggatagc ttgaagccag   1200

gagtttgcaa tcagctttga aaacaaagag agaccctgac tctaccaaaa aataaaaata   1260

aaacaataaa aaactggcca ggcgtggtgg                                    1290


<210>  6868
<211>  100
<212>  PRT
<213>  Homosapiens

<400>  6868

Met Gly Ala Tyr His Val Asp Ala Glu Ala Phe Val Arg Gly Ser Pro 
1               5                   10                  15      


Asp His Leu Leu Asp Leu Ile Tyr Arg Tyr Glu Asp Ser Asp Ala Ser 
            20                  25                  30          


Thr Pro Arg Leu Gly Gly Arg Val Ile Gln Val Gly Ser Arg Leu Val 
        35                  40                  45              


Asp Val Pro Tyr Val Ile Gln Arg Ala Gly Ala Gly Ser Ser Leu Pro 
    50                  55                  60                  


Trp Gln Leu Val Pro Leu Ser Pro Ala Ser Ser Phe Pro Leu Phe Phe 
65                  70                  75                  80  


Val Cys Leu Leu Val Phe Val Phe His Phe Tyr Leu Leu Gln Ile Asp 
                85                  90                  95      


Leu Asn Ile Phe 
            100 


<210>  6869
<211>  3270
<212>  DNA
<213>  Homosapiens

<400>  6869
tttcctacct tctgaggctt caaagtattt tttaaaatct atgctttgtg gcagctctac     60

ggtgcttatc tctgtctttg tgtcaatcct taagtaccca tgtctttttc atgtctaacc    120

attgggaagg tagaggctgg cagggaagac aaatctgcta caagtccatg ggaagaccct    180

acaatgaaat gttcattggt tggtatactg ttttagtctt gaattgccaa ctttccaact    240

gatctatcca tattccttaa gtactaaaga caaaatagag ggcttctttt tctctcttaa    300

tgtcttgcct tctggttttc ctggtttgca agactaagtg tacctaatct caccatctct    360

tcacttctag ctctctgaaa caagggtcac actactcaga gggataaccc cttacagtgg    420

tctgaggagt aactatttcc taaagtattc taaaagagta ggaagagaga aatggtagcc    480

tgctgcttct cacagacacc tcacatcctc acttgggatg gcatccacat agaaaccctg    540

catttaggta aaatttgcct gactgaaggg gactcagtcc tccaaatcaa ggtcaagaag    600

atatctgcat gagaccttaa gaactcttta ttgccattat ttggagaggg cgggggaatt    660

gtcctaatca cacatttaac acagggaata agtgctgaag tgacccagat caccaagcgc    720

agttcctcat catactttat ttttgctttc cttattcctt ggcactgact aagctaaagt    780

taagaagccg acttcataag ccaacccctg tgatgggatg gaaaaatggg cttttgcaga    840

gggtttatta atagagatgg atatactact cacaagttct ggctcatggc tccactgaga    900

aggccatagt aataaaatga tcttatgaac actgttcccc aaaggccaaa gcctgaagat    960

attgcccctt ataatccaat cagccttata ttttaataag tcctgaatca acctgactac   1020

ggatatatgg ggccaccagg gtgcatgggt gcatgtctgc tcagcctagc cctggaagtg   1080

agcactgccg gccacagatc ctgggaaagg tggtagtaac ccagaagatg tagccttgaa   1140

gggaggatac ctatcaaaat gccaaagctg cagggacacg aagacggttg aaaattcaac   1200

ctgtgtatac tagatccttc cagtttgatg gtttggtcat tcttcttcat gattatacca   1260

tggagaattt tctgtgacaa gggtggtcat ggaagtaagt gagtgatccc ctggtttctc   1320

attccttaaa gcagtggttc gcaaagtatg gcacaagacc agcagcatca gcagcctttg   1380

ggaacttgtt agaaacgaaa attctcaatc ccatcccaga tctgctgaat cagaaactct   1440

aatgagagga cccggcaatc cacgttttaa taagccctcc tggtgattct gatgcacact   1500

aaattcaact gttttaaagg gaaagccctt tatagtattg gagttcccac agtctcttcc   1560

agattgctct tctgccgaat tatttgtatc tattccgagc tgattatgta ataggatgga   1620

aaaagtaaaa aaaaaaaaaa aaatctaatt tgtatttcca tgacaacgtg ttctcccagc   1680

aacatccctc tcctttattt gagttataaa gggcactgct gggcctgaga accaggccag   1740

aacctccttc tgtatggcag ctaacagtgt agggctccag tatcccagga aggcccctta   1800

tccacactcc actcagctca taggagagtc ttgcataatg aagacacaga cctgggcact   1860

tcagtccttg tgctcctcct ctcttttccc cacagcagga cctggataca gaagtactca   1920

gccaaggtga cagaataaaa tccttttttt gttgttttct gtttgtttgt ttgttttgga   1980

gaaggagtct cgctttgtca cccaggctgg tgtgcagtgg cacgatctcg gctcactgca   2040

acctccgcct cccaggttca agcgattctc ctgtctcagc ctcctgagta gctgggatta   2100

cagacgtgcg ccatcacgcc cagctaattt ttgtattttt agtagatacg gagttttgcc   2160

ttgttggcca ggctgtgctg gagctcctga cctcaggtga ttcacctgcc acagcctccc   2220

aaagtgctgg gattacaggc gtgagccaca gcaccctgcc aaataagatc ctttttaaaa   2280

aatatctgaa aaaagcttca tatctttaca aactcataaa atagctgatt gggccatgga   2340

ggagatgagg ctgtttagaa ctggttttgt ttcaagtttg tcaattttcc ctgtatgaga   2400

acttgggtaa agcacaaaga aacatacagt gctagtaaca ggtctcctgc gccctggaac   2460

taagtgtttg gaggaaggac taaaccccgg gggaggtgag tataaaataa ttccactaag   2520

atcacctcct cagtccccag aaggctgatg gtggatcctc tggccatctc ctgtggggtc   2580

ttactgctcc tctgccattt ctctatgcct gaagacacga agatgatatc aaggcagagc   2640

taccatatcg cagccagtct ctaggctact gctgtgcagt ggctcccact ttctaatgct   2700

tttttgtttt tgctttttct aacaaaacaa tcttttttca aaatgaattc caacccctgc   2760

tagcttcctt ccccgcctcc atactgtttt aggcagcacc gtttatgtga cagagtccgt   2820

gtttctcaaa tgcatggtgt tcctcaggtg gagagtgggc agaagttttt gcaacacttt   2880

ttttttaagt tattgggtgc aaaatcccaa accaggatat gtgtatgtct gtgtgtttat   2940

gttttttatt tgaccctccc ctctttcaac ctaccccctt ttatatctaa tgtagaaaaa   3000

gcgaaattga atctggaaag caaactgttg tatatagttg cggtaacaat catgaagaga   3060

gagccgggct gtcccctcag taattcattt taaataacaa attatttaaa aataaaattc   3120

atgccagagc cagctgaaga ggccttcctt catcaccact gaggccaccc ccaatctggg   3180

ccctctgtcc atctggcatg tctcctccca gcaagattca tctgttcaat gccatttgcg   3240

tttcaataaa gttatctcct gtactgtcca                                    3270


<210>  6870
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  6870

Met His Thr Lys Phe Asn Cys Phe Lys Gly Lys Ala Leu Tyr Ser Ile 
1               5                   10                  15      


Gly Val Pro Thr Val Ser Ser Arg Leu Leu Phe Cys Arg Ile Ile Cys 
            20                  25                  30          


Ile Tyr Ser Glu Leu Ile Met 
        35                  


<210>  6871
<211>  3232
<212>  DNA
<213>  Homosapiens

<400>  6871
tttcctacct tctgaggctt caaagtattt tttaaaatct atgctttgtg gcagctctac     60

ggtgcttatc tctgtctttg tgtcaatcct taagtaccca tgtctttttc atgtctaacc    120

attgggaagg tagaggctgg cagggaagac aaatctgcta caagtccatg ggaagaccct    180

acaatgaaat gttcattggt tggtatactg ttttagtctt gaattgccaa ctttccaact    240

gatctatcca tattccttaa gtactaaaga caaaatagag ggcttctttt tctctcttaa    300

tgtcttgcct tctggttttc ctggtttgca agactaagtg tacctaatct caccatctct    360

tcacttctag ctctctgaaa caagggtcac actactcaga gggataaccc cttacagtgg    420

tctgaggagt aactatttcc taaagtattc taaaagagta ggaagagaga aatggtagcc    480

tgctgcttct cacagacacc tcacatcctc acttgggatg gcatccacat agaaaccctg    540

catttaggta aaatttgcct gactgaaggg gactcagtcc tccaaatcaa ggtcaagaag    600

atatctgcat gagaccttaa gaactcttta ttgccattat ttggagaggg cgggggaatt    660

gtcctaatca cacatttaac acagggaata agtgctgaag tgacccagat caccaagcgc    720

agttcctcat catactttat ttttgctttc cttattcctt ggcactgact aagctaaagt    780

taagaagccg acttcataag ccaacccctg tgatgggatg gaaaaatggg cttttgcaga    840

gggtttatta atagagatgg atatactact cacaagttct ggctcatggc tccactgaga    900

aggccatagt aataaaatga tcttatgaac actgttcccc aaaggccaaa gcctgaagat    960

attgcccctt ataatccaat cagccttata ttttaataag tcctgaatca acctgactac   1020

ggatatatgg ggccaccagg gtgcatgggt gcatgtctgc tcagcctagc cctggaagtg   1080

agcactgccg gccacagatc ctgggaaagg tggtagtaac ccagaagatg tagccttgaa   1140

gggaggatac ctatcaaaat gccaaagctg cagggacacg aagacggttg aaaattcaac   1200

ctgtgtatac tagatccttc cagtttgatg gtttggtcat tcttcttcat gattatacca   1260

tggagaattt tctgtgacaa gggtggtcat ggaagtaagt gagtgatccc ctggtttctc   1320

attccttaaa gcagtggttc gcaaagtatg gcacaagacc agcagcatca gcagcctttg   1380

ggaacttgtt agaaacgaaa attctcaatc ccatcccaga tctgctgaat cagaaactct   1440

aatgagagga cccggcaatc cacgttttat acctggcaca caaaggggct tcaacaagga   1500

aaagcagttg gaggtctctt ccagattgct cttctgccga attatttgta tctattccga   1560

gctgattatg taataggatg gaaaaagtaa aaaaaaaaaa aaaaatctaa tttgtatttc   1620

catgacaacg tgttctccca gcaacatccc tctcctttat ttgagttata aagggcactg   1680

ctgggcctga gaaccaggcc agaacctcct tctgtatggc agctaacagt gtagggctcc   1740

agtatcccag gaaggcccct tatccacact ccactcagct cataggagag tcttgcataa   1800

tgaagacaca gacctgggca cttcagtcct tgtgctcctc ctctcttttc cccacagcag   1860

gacctggata cagaagtact cagccaaggt gacagaataa aatccttttt ttgttgtttt   1920

ctgtttgttt gtttgttttg gagaaggagt ctcgctttgt cacccaggct ggtgtgcagt   1980

ggcacgatct cggctcactg caacctccgc ctcccaggtt caagcgattc tcctgtctca   2040

gcctcctgag tagctgggat tacagacgtg cgccatcacg cccagctaat ttttgtattt   2100

ttagtagata cggagttttg ccttgttggc caggctgtgc tggagctcct gacctcaggt   2160

gattcacctg ccacagcctc ccaaagtgct gggattacag gcgtgagcca cagcaccctg   2220

ccaaataaga tcctttttaa aaaatatctg aaaaaagctt catatcttta caaactcata   2280

aaatagctga ttgggccatg gaggagatga ggctgtttag aactggtttt gtttcaagtt   2340

tgtcaatttt ccctgtatga gaacttgggt aaagcacaaa gaaacataca gtgctagtaa   2400

caggtctcct gcgccctgga actaagtgtt tggaggaagg actaaacccc gggggaggtg   2460

agtataaaat aattccacta agatcacctc ctcagtcccc agaaggctga tggtggatcc   2520

tctggccatc tcctgtgggg tcttactgct cctctgccat ttctctatgc ctgaagacac   2580

gaagatgata tcaaggcaga gctaccatat cgcagccagt ctctaggcta ctgctgtgca   2640

gtggctccca ctttctaatg cttttttgtt tttgcttttt ctaacaaaac aatctttttt   2700

caaaatgaat tccaacccct gctagcttcc ttccccgcct ccatactgtt ttaggcagca   2760

ccgtttatgt gacagagtcc gtgtttctca aatgcatggt gttcctcagg tggagagtgg   2820

gcagaagttt ttgcaacact ttttttttaa gttattgggt gcaaaatccc aaaccaggat   2880

atgtgtatgt ctgtgtgttt atgtttttta tttgaccctc ccctctttca acctaccccc   2940

ttttatatct aatgtagaaa aagcgaaatt gaatctggaa agcaaactgt tgtatatagt   3000

tgcggtaaca atcatgaaga gagagccggg ctgtcccctc agtaattcat tttaaataac   3060

aaattattta aaaataaaat tcatgccaga gccagctgaa gaggccttcc ttcatcacca   3120

ctgaggccac ccccaatctg ggccctctgt ccatctggca tgtctcctcc cagcaagatt   3180

catctgttca atgccatttg cgtttcaata aagttatctc ctgtactgtc ca           3232


<210>  6872
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  6872

Met Arg Gly Pro Gly Asn Pro Arg Phe Ile Pro Gly Thr Gln Arg Gly 
1               5                   10                  15      


Phe Asn Lys Glu Lys Gln Leu Glu Val Ser Ser Arg Leu Leu Phe Cys 
            20                  25                  30          


Arg Ile Ile Cys Ile Tyr Ser Glu Leu Ile Met 
        35                  40              


<210>  6873
<211>  3471
<212>  DNA
<213>  Homosapiens

<400>  6873
ggggctggcg ggctgagggg agaaaagatg gcggcggcgg cggcagctgg tgcggcctcc     60

gggctgccgg gtccagtggc acaaggatta aaggaagcgt tagtggatac gctcaccggg    120

atcctatccc cagtacagga ggtgcgggcg gctgctgaag aacagattaa ggtgctggag    180

gtgacggagg aatttggtgt tcacttggca gaactgactg tagatcccca gggggcactg    240

gcaatccgtc agctggcatc agtcatcttg aaacaatatg tggagactca ctggtgtgcc    300

caatcagaga aatttaggcc tcctgaaact acagaaaggg caaaaattgt tatccgggag    360

ctattgccta atgggttgag agaatcgata agcaaagtgc gctccagtgt ggcctatgca    420

gtgtcagcca ttgcccactg ggactggcct gaagcttggc cccaactctt caacctgctc    480

atggagatgt tggtgagcgg agacttaaat gccgtccatg gagccatgcg tgtgctgaca    540

gaattcactc gtgaagtaac agacacacag atgccacttg ttgctcctgt cattctccca    600

gagatgtata agatcttcac catggctgag gtgtatggta ttcgaacccg ttcccgagcc    660

gtggagattt ttaccacttg tgcccatatg atctgtaaca tggaggagct ggaaaagggt    720

gcagccaaag tcctgatctt tcccgtggta cagcagttca cagaggcctt tgttcaggcc    780

ctccagatac cagatggccc cacatctgac agtgggttta agatggaggt cctaaaggca    840

gtgacagccc tagtgaaaaa cttcccaaag cacatggtgt cctccatgca gcagattctg    900

cctattgttt ggaacaccct aaccgagagt gcagcttttt atgtgaggac agaagtaaat    960

tacacagaag aagtagaaga tcctgtggat tctgatggtg aagtcctggg ctttgaaaat   1020

ctcgtcttta gcatttttga atttgtccat gctctactag aaaatagcaa attcaaaagc   1080

actgttaaga aagccttgcc tgaattgatt tattatatta tcctgtacat gcaaatcact   1140

gaggagcaga ttaaagtatg gacagccaac ccccaacaat ttgtagaaga tgaagatgat   1200

gatacattct cctatactgt tagaatagca gctcaagact tgttgctggc tgtggccaca   1260

gatttccaga atgaaagtgc agcagccctg gctgctgcag ccactcgaca tttacaagaa   1320

gctgagcaaa ccaaaaacag tggcactgag cactggtgga agatccatga ggcatgcatg   1380

cttgccctag gctcagtgaa ggccatcatc actgacagtg tgaaaaatgg caggattcat   1440

tttgacatgc atgggttcct gaccaatgtc atccttgcag acctcaacct ctcagtgtct   1500

cctttcctct tgggccgggc actttgggct gccagtcggt tcactgttgc tatgtcccct   1560

gaactgatcc agcagttcct acaggcaaca gttagtggtc ttcacgagac acagccccca   1620

tcagttcgaa tttctgcagt gagagccatc tggggttatt gtgaccaact gaaagtctca   1680

gagagtaccc acgtgctcca gcccttcctc cccagcatcc ttgatggctt aattcaccta   1740

gcagcccagt tcagctcaga ggtcctcaac ctggtgatgg agaccctgtg catcgtttgt   1800

acagtagacc ccgaattcac agcaagcatg gaaagcaaaa tctgcccctt caccatcgcc   1860

attttcctaa agtacagtaa tgatcccgtc gtcgcctcac tggctcagga catcttcaag   1920

gagctgtccc agattgaagc ctgtcagggc ccaatgcaaa tgaggctgat tcccactctg   1980

gtcagcataa tgcaggcccc agcagacaag attcctgcag ggctttgtgc gacagccatt   2040

gatatcctga caacagtagt acgaaataca aagcctcccc tttcccagct tctcatctgc   2100

caagctttcc ctgctgtggc acagtgtacc cttcacacag atgacaatgc caccatgcag   2160

aatggcggag agtgcttgcg ggcctatgtg tcagtgaccc tggaacaagt agcccagtgg   2220

catgatgagc agggccacaa tggactgtgg tatgtgatgc aagtggtgag ccagctcctg   2280

gacccccgca cctcagagtt cactgcggcc tttgtgggcc gccttgtttc caccctcatc   2340

tccaaggcag ggcgggaact cggggagaat ctagaccaga ttcttcgtgc catcctcagt   2400

aagatgcagc aggcagagac gctcagtgtc atgcagtccc tgatcatggt gttcgctcat   2460

ctggtgcaca ctcagctaga acctctcttg gagttcctgt gtagcctccc aggacctact   2520

ggcaaacctg ctctagagtt tgtgatggct gagtggacaa gccgacagca cctgttctat   2580

ggacagtatg aaggcaaagt cagctctgtg gcactctgta agctgctcca gcatggcatc   2640

aatgcagatg acaaacggct acaggatatc cgtgtgaagg gagaggagat ctacagcatg   2700

gatgagggca tccgcacccg ctctaagtca gccaaaaacc cagaacgctg gacaaacatt   2760

cctttgctgg tcaagatcct aaagctgatc atcaacgagc tctccaacgt catggaggct   2820

aatgccgctc gccaggccac tcctgcagag tggagtcaag atgactccaa tgatatgtgg   2880

gaggaccagg aggaggaaga ggaggaggag gaggatggtt tagctggcca acttttatct   2940

gacattcttg ctacaagtaa atatgaggag gattactacg aggatgatga ggaagatgac   3000

cctgatgccc tgaaggatcc tctctatcag attgatctgc aggcatatct cacagatttc   3060

ctctgccagt ttgctcagca gccctgctac ataatgtttt caggccacct taatgacaat   3120

gagaggcgag ttctacagac catcggcatc taaaaagggg agcctttcta catttgctcc   3180

ttctgggcca gccgcaaacc attttgcagc cctcactggc cttgagatgc actttcttct   3240

caacctaaag tggcatcttg acccttggcc cttggcctcg gcagtgacac tgatgacaat   3300

tcagaccagg ctcaccggtg ccgtcactta ggaatgctgg aacaaaggac atttctcaaa   3360

gttcccctga agacatgcca tctctagaac cttttttctc cccgactcta cccccacctc   3420

tgttcctaga gccctctgct ggcgagtcca gaaacattat tgcccagaag g            3471


<210>  6874
<211>  1041
<212>  PRT
<213>  Homosapiens

<400>  6874

Met Ala Ala Ala Ala Ala Ala Gly Ala Ala Ser Gly Leu Pro Gly Pro 
1               5                   10                  15      


Val Ala Gln Gly Leu Lys Glu Ala Leu Val Asp Thr Leu Thr Gly Ile 
            20                  25                  30          


Leu Ser Pro Val Gln Glu Val Arg Ala Ala Ala Glu Glu Gln Ile Lys 
        35                  40                  45              


Val Leu Glu Val Thr Glu Glu Phe Gly Val His Leu Ala Glu Leu Thr 
    50                  55                  60                  


Val Asp Pro Gln Gly Ala Leu Ala Ile Arg Gln Leu Ala Ser Val Ile 
65                  70                  75                  80  


Leu Lys Gln Tyr Val Glu Thr His Trp Cys Ala Gln Ser Glu Lys Phe 
                85                  90                  95      


Arg Pro Pro Glu Thr Thr Glu Arg Ala Lys Ile Val Ile Arg Glu Leu 
            100                 105                 110         


Leu Pro Asn Gly Leu Arg Glu Ser Ile Ser Lys Val Arg Ser Ser Val 
        115                 120                 125             


Ala Tyr Ala Val Ser Ala Ile Ala His Trp Asp Trp Pro Glu Ala Trp 
    130                 135                 140                 


Pro Gln Leu Phe Asn Leu Leu Met Glu Met Leu Val Ser Gly Asp Leu 
145                 150                 155                 160 


Asn Ala Val His Gly Ala Met Arg Val Leu Thr Glu Phe Thr Arg Glu 
                165                 170                 175     


Val Thr Asp Thr Gln Met Pro Leu Val Ala Pro Val Ile Leu Pro Glu 
            180                 185                 190         


Met Tyr Lys Ile Phe Thr Met Ala Glu Val Tyr Gly Ile Arg Thr Arg 
        195                 200                 205             


Ser Arg Ala Val Glu Ile Phe Thr Thr Cys Ala His Met Ile Cys Asn 
    210                 215                 220                 


Met Glu Glu Leu Glu Lys Gly Ala Ala Lys Val Leu Ile Phe Pro Val 
225                 230                 235                 240 


Val Gln Gln Phe Thr Glu Ala Phe Val Gln Ala Leu Gln Ile Pro Asp 
                245                 250                 255     


Gly Pro Thr Ser Asp Ser Gly Phe Lys Met Glu Val Leu Lys Ala Val 
            260                 265                 270         


Thr Ala Leu Val Lys Asn Phe Pro Lys His Met Val Ser Ser Met Gln 
        275                 280                 285             


Gln Ile Leu Pro Ile Val Trp Asn Thr Leu Thr Glu Ser Ala Ala Phe 
    290                 295                 300                 


Tyr Val Arg Thr Glu Val Asn Tyr Thr Glu Glu Val Glu Asp Pro Val 
305                 310                 315                 320 


Asp Ser Asp Gly Glu Val Leu Gly Phe Glu Asn Leu Val Phe Ser Ile 
                325                 330                 335     


Phe Glu Phe Val His Ala Leu Leu Glu Asn Ser Lys Phe Lys Ser Thr 
            340                 345                 350         


Val Lys Lys Ala Leu Pro Glu Leu Ile Tyr Tyr Ile Ile Leu Tyr Met 
        355                 360                 365             


Gln Ile Thr Glu Glu Gln Ile Lys Val Trp Thr Ala Asn Pro Gln Gln 
    370                 375                 380                 


Phe Val Glu Asp Glu Asp Asp Asp Thr Phe Ser Tyr Thr Val Arg Ile 
385                 390                 395                 400 


Ala Ala Gln Asp Leu Leu Leu Ala Val Ala Thr Asp Phe Gln Asn Glu 
                405                 410                 415     


Ser Ala Ala Ala Leu Ala Ala Ala Ala Thr Arg His Leu Gln Glu Ala 
            420                 425                 430         


Glu Gln Thr Lys Asn Ser Gly Thr Glu His Trp Trp Lys Ile His Glu 
        435                 440                 445             


Ala Cys Met Leu Ala Leu Gly Ser Val Lys Ala Ile Ile Thr Asp Ser 
    450                 455                 460                 


Val Lys Asn Gly Arg Ile His Phe Asp Met His Gly Phe Leu Thr Asn 
465                 470                 475                 480 


Val Ile Leu Ala Asp Leu Asn Leu Ser Val Ser Pro Phe Leu Leu Gly 
                485                 490                 495     


Arg Ala Leu Trp Ala Ala Ser Arg Phe Thr Val Ala Met Ser Pro Glu 
            500                 505                 510         


Leu Ile Gln Gln Phe Leu Gln Ala Thr Val Ser Gly Leu His Glu Thr 
        515                 520                 525             


Gln Pro Pro Ser Val Arg Ile Ser Ala Val Arg Ala Ile Trp Gly Tyr 
    530                 535                 540                 


Cys Asp Gln Leu Lys Val Ser Glu Ser Thr His Val Leu Gln Pro Phe 
545                 550                 555                 560 


Leu Pro Ser Ile Leu Asp Gly Leu Ile His Leu Ala Ala Gln Phe Ser 
                565                 570                 575     


Ser Glu Val Leu Asn Leu Val Met Glu Thr Leu Cys Ile Val Cys Thr 
            580                 585                 590         


Val Asp Pro Glu Phe Thr Ala Ser Met Glu Ser Lys Ile Cys Pro Phe 
        595                 600                 605             


Thr Ile Ala Ile Phe Leu Lys Tyr Ser Asn Asp Pro Val Val Ala Ser 
    610                 615                 620                 


Leu Ala Gln Asp Ile Phe Lys Glu Leu Ser Gln Ile Glu Ala Cys Gln 
625                 630                 635                 640 


Gly Pro Met Gln Met Arg Leu Ile Pro Thr Leu Val Ser Ile Met Gln 
                645                 650                 655     


Ala Pro Ala Asp Lys Ile Pro Ala Gly Leu Cys Ala Thr Ala Ile Asp 
            660                 665                 670         


Ile Leu Thr Thr Val Val Arg Asn Thr Lys Pro Pro Leu Ser Gln Leu 
        675                 680                 685             


Leu Ile Cys Gln Ala Phe Pro Ala Val Ala Gln Cys Thr Leu His Thr 
    690                 695                 700                 


Asp Asp Asn Ala Thr Met Gln Asn Gly Gly Glu Cys Leu Arg Ala Tyr 
705                 710                 715                 720 


Val Ser Val Thr Leu Glu Gln Val Ala Gln Trp His Asp Glu Gln Gly 
                725                 730                 735     


His Asn Gly Leu Trp Tyr Val Met Gln Val Val Ser Gln Leu Leu Asp 
            740                 745                 750         


Pro Arg Thr Ser Glu Phe Thr Ala Ala Phe Val Gly Arg Leu Val Ser 
        755                 760                 765             


Thr Leu Ile Ser Lys Ala Gly Arg Glu Leu Gly Glu Asn Leu Asp Gln 
    770                 775                 780                 


Ile Leu Arg Ala Ile Leu Ser Lys Met Gln Gln Ala Glu Thr Leu Ser 
785                 790                 795                 800 


Val Met Gln Ser Leu Ile Met Val Phe Ala His Leu Val His Thr Gln 
                805                 810                 815     


Leu Glu Pro Leu Leu Glu Phe Leu Cys Ser Leu Pro Gly Pro Thr Gly 
            820                 825                 830         


Lys Pro Ala Leu Glu Phe Val Met Ala Glu Trp Thr Ser Arg Gln His 
        835                 840                 845             


Leu Phe Tyr Gly Gln Tyr Glu Gly Lys Val Ser Ser Val Ala Leu Cys 
    850                 855                 860                 


Lys Leu Leu Gln His Gly Ile Asn Ala Asp Asp Lys Arg Leu Gln Asp 
865                 870                 875                 880 


Ile Arg Val Lys Gly Glu Glu Ile Tyr Ser Met Asp Glu Gly Ile Arg 
                885                 890                 895     


Thr Arg Ser Lys Ser Ala Lys Asn Pro Glu Arg Trp Thr Asn Ile Pro 
            900                 905                 910         


Leu Leu Val Lys Ile Leu Lys Leu Ile Ile Asn Glu Leu Ser Asn Val 
        915                 920                 925             


Met Glu Ala Asn Ala Ala Arg Gln Ala Thr Pro Ala Glu Trp Ser Gln 
    930                 935                 940                 


Asp Asp Ser Asn Asp Met Trp Glu Asp Gln Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Glu Asp Gly Leu Ala Gly Gln Leu Leu Ser Asp Ile Leu Ala Thr 
                965                 970                 975     


Ser Lys Tyr Glu Glu Asp Tyr Tyr Glu Asp Asp Glu Glu Asp Asp Pro 
            980                 985                 990         


Asp Ala Leu Lys Asp Pro Leu Tyr  Gln Ile Asp Leu Gln  Ala Tyr Leu 
        995                 1000                 1005             


Thr Asp  Phe Leu Cys Gln Phe  Ala Gln Gln Pro Cys  Tyr Ile Met 
    1010                 1015                 1020             


Phe Ser  Gly His Leu Asn Asp  Asn Glu Arg Arg Val  Leu Gln Thr 
    1025                 1030                 1035             


Ile Gly  Ile 
    1040     


<210>  6875
<211>  3853
<212>  DNA
<213>  Homosapiens

<400>  6875
ggggctggcg ggctgagggg agaaaagatg gcggcggcgg cggcagctgg tgcggcctcc     60

gggctgccgg gtccagtggc acaaggatta aaggaagcgt tagtggatac gctcaccggg    120

atcctatccc cagtacagga ggtgcgggcg gctgctgaag aacagattaa ggtgctggag    180

gtgacggagg aatttggtgt tcacttggca gaactgactg tagatcccca gggggcactg    240

gcaatccgtc agctggcatc agtcatcttg aaacaatatg tggagactca ctggtgtgcc    300

caatcagaga aatttaggcc tcctgaaact acagaaaggg caaaaattgt tatccgggag    360

ctattgccta atgggttgag agaatcgata agcaaagtgc gctccagtgt ggcctatgca    420

gtgtcagcca ttgcccactg ggactggcct gaagcttggc cccaactctt caacctgctc    480

atggagatgt tggtgagcgg agacttaaat gccgtccatg gagccatgcg tgtgctgaca    540

gaattcactc gtgaagtaac agacacacag atgccacttg ttgctcctgt cattctccca    600

gagatgtata agatcttcac catggctgag gtgtatggta ttcgaacccg ttcccgagcc    660

gtggagattt ttaccacttg tgcccatatg atctgtaaca tggaggagct ggaaaagggt    720

gcagccaaag tcctgatctt tcccgtggta cagcagttca cagaggcctt tgttcaggcc    780

ctccagatac cagatggccc cacatctgac agtgggttta agatggaggt cctaaaggca    840

gtgacagccc tagtgaaaaa cttcccaaag cacatggtgt cctccatgca gcagattctg    900

cctattgttt ggaacaccct aaccgagagt gcagcttttt atgtgaggac agaagtaaat    960

tacacagaag aagtagaaga tcctgtggat tctgatggtg aagtcctggg ctttgaaaat   1020

ctcgtcttta gcatttttga atttgtccat gctctactag aaaatagcaa attcaaaagc   1080

actgttaaga aagccttgcc tgaattgatt tattatatta tcctgtacat gcaaatcact   1140

gaggagcaga ttaaagtatg gacagccaac ccccaacaat ttgtagaaga tgaagatgat   1200

gatacattct cctatactgt tagaatagca gctcaagact tgttgctggc tgtggccaca   1260

gatttccaga atgaaagtgc agcagccctg gctgctgcag ccactcgaca tttacaagaa   1320

gctgagcaaa ccaaaaacag tggcactgag cactggtgga agatccatga ggcatgcatg   1380

cttgccctag gctcagtgaa ggccatcatc actgacagtg tgaaaaatgg caggattcat   1440

tttgacatgc atgggttcct gaccaatgtc atccttgcag acctcaacct ctcagtgtct   1500

cctttcctct tgggccgggc actttgggct gccagtcggt tcactgttgc tatgtcccct   1560

gaactgatcc agcagttcct acaggcaaca gttagtggtc ttcacgagac acagccccca   1620

tcagttcgaa tttctgcagt gagagccatc tggggttatt gtgaccaact gaaagtctca   1680

gagagtaccc acgtgctcca gcccttcctc cccagcatcc ttgatggctt aattcaccta   1740

gcagcccagt tcagctcaga ggtcctcaac ctggtgatgg agaccctgtg catcgtttgt   1800

acagtagacc ccgaattcac agcaagcatg gaaagcaaaa tctgcccctt caccatcgcc   1860

attttcctaa agtacagtaa tgatcccgtc gtcgcctcac tggctcagga catcttcaag   1920

gagctgtccc agattgaagc ctgtcagggc ccaatgcaaa tgaggctgat tcccactctg   1980

gtcagcataa tgcaggcccc agcagacaag attcctgcag ggctttgtgc gacagccatt   2040

gatatcctga caacagtagt acgaaataca aagcctcccc tttcccagct tctcatctgc   2100

caagctttcc ctgctgtggc acagtgtacc cttcacacag atgacaatgc caccatgcag   2160

aatggcggag agtgcttgcg ggcctatgtg tcagtgaccc tggaacaagt agcccagtgg   2220

catgatgagc agggccacaa tggactgtgg tatgtgatgc aagtggtgag ccagctcctg   2280

gacccccgca cctcagagtt cactgcggcc tttgtgggcc gccttgtttc caccctcatc   2340

tccaaggcag ggcgggaact cggggagaat ctagaccaga ttcttcgtgc catcctcagt   2400

aagatgcagc aggcagagac gctcagtgtc atgcagtccc tgatcatggt gttcgctcat   2460

ctggtgcaca ctcagctaga acctctcttg gagttcctgt gtagcctccc aggacctact   2520

ggcaaacctg ctctagagtt tgtgatggct gagtggacaa gccgacagca cctgttctat   2580

ggacagtatg aaggcaaagt cagctctgtg gcactctgta agctgctcca gcatggcatc   2640

aatgcagatg acaaacggct acaggatatc cgtgtgaagg gagaggagat ctacagcatg   2700

gatgagggca tccgcacccg ctctaagtca gccaaaaacc cagaacgctg gacaaacatt   2760

cctttgctgg tcaagatcct aaagctgatc atcaacgagc tctccaacgt catggaggct   2820

aatgccgctc gccaggccac tcctgcagag tggagtcaag atgactccaa tgatatgtgg   2880

gaggaccagg aggaggaaga ggaggaggag gaggatggtt tagctggcca acttttatct   2940

gacattcttg ctacaagtaa atatgaggag gattactacg aggatgatga ggaagatgac   3000

cctgatgccc tgaaggatcc tctctatcag attgatctgc aggcatatct cacagatttc   3060

ctctgccagt ttgctcagca gccctgctac ataatgtttt caggccacct taatgacaat   3120

gagaggcgag ttctacagac catcggcatc taaaaagggg agcctttcta catttgctcc   3180

ttctgggcca gccgcaaacc attttgcagc cctcactggc cttgagatgc actttcttct   3240

caacctaaag tggcatcttg acccttggcc cttggcctcg gcagtgacac tgatgacaat   3300

tcagaccagg ctcaccggtg ccgtcactta ggaatgctgg aacaaaggac atttctcaaa   3360

gttcccctga agacatgcca tctctagaac cttttttctc cccgactcta cccccacctc   3420

tgttcctaga gccctctgct ggcgagtcca gaaacattat tgcccagaag gattatgtgt   3480

ttatggatta ttttgccccg cctcaggagc gcaggaagtc actaccattt atattctaaa   3540

acagacctat ctatgttcat aggacttctg atgtgttcag ataggaatcc tcatgagaga   3600

tcattatgct ttgtgccctg gaccactgct gctctgggtt ctcaggagga acaggcaaga   3660

gcagcttcat tctaagcctt tccagtgacc tcagccttgc ttctcttcta caacactaag   3720

gctcctctgt cagaggaggt cgtcttgttt ttgcttcatt gcatgacata acccttcccc   3780

tcaagctgtt cctatatata catgcacaca caaaataagc cagacagatg gcaatttgat   3840

cttccttttt tag                                                      3853


<210>  6876
<211>  1041
<212>  PRT
<213>  Homosapiens

<400>  6876

Met Ala Ala Ala Ala Ala Ala Gly Ala Ala Ser Gly Leu Pro Gly Pro 
1               5                   10                  15      


Val Ala Gln Gly Leu Lys Glu Ala Leu Val Asp Thr Leu Thr Gly Ile 
            20                  25                  30          


Leu Ser Pro Val Gln Glu Val Arg Ala Ala Ala Glu Glu Gln Ile Lys 
        35                  40                  45              


Val Leu Glu Val Thr Glu Glu Phe Gly Val His Leu Ala Glu Leu Thr 
    50                  55                  60                  


Val Asp Pro Gln Gly Ala Leu Ala Ile Arg Gln Leu Ala Ser Val Ile 
65                  70                  75                  80  


Leu Lys Gln Tyr Val Glu Thr His Trp Cys Ala Gln Ser Glu Lys Phe 
                85                  90                  95      


Arg Pro Pro Glu Thr Thr Glu Arg Ala Lys Ile Val Ile Arg Glu Leu 
            100                 105                 110         


Leu Pro Asn Gly Leu Arg Glu Ser Ile Ser Lys Val Arg Ser Ser Val 
        115                 120                 125             


Ala Tyr Ala Val Ser Ala Ile Ala His Trp Asp Trp Pro Glu Ala Trp 
    130                 135                 140                 


Pro Gln Leu Phe Asn Leu Leu Met Glu Met Leu Val Ser Gly Asp Leu 
145                 150                 155                 160 


Asn Ala Val His Gly Ala Met Arg Val Leu Thr Glu Phe Thr Arg Glu 
                165                 170                 175     


Val Thr Asp Thr Gln Met Pro Leu Val Ala Pro Val Ile Leu Pro Glu 
            180                 185                 190         


Met Tyr Lys Ile Phe Thr Met Ala Glu Val Tyr Gly Ile Arg Thr Arg 
        195                 200                 205             


Ser Arg Ala Val Glu Ile Phe Thr Thr Cys Ala His Met Ile Cys Asn 
    210                 215                 220                 


Met Glu Glu Leu Glu Lys Gly Ala Ala Lys Val Leu Ile Phe Pro Val 
225                 230                 235                 240 


Val Gln Gln Phe Thr Glu Ala Phe Val Gln Ala Leu Gln Ile Pro Asp 
                245                 250                 255     


Gly Pro Thr Ser Asp Ser Gly Phe Lys Met Glu Val Leu Lys Ala Val 
            260                 265                 270         


Thr Ala Leu Val Lys Asn Phe Pro Lys His Met Val Ser Ser Met Gln 
        275                 280                 285             


Gln Ile Leu Pro Ile Val Trp Asn Thr Leu Thr Glu Ser Ala Ala Phe 
    290                 295                 300                 


Tyr Val Arg Thr Glu Val Asn Tyr Thr Glu Glu Val Glu Asp Pro Val 
305                 310                 315                 320 


Asp Ser Asp Gly Glu Val Leu Gly Phe Glu Asn Leu Val Phe Ser Ile 
                325                 330                 335     


Phe Glu Phe Val His Ala Leu Leu Glu Asn Ser Lys Phe Lys Ser Thr 
            340                 345                 350         


Val Lys Lys Ala Leu Pro Glu Leu Ile Tyr Tyr Ile Ile Leu Tyr Met 
        355                 360                 365             


Gln Ile Thr Glu Glu Gln Ile Lys Val Trp Thr Ala Asn Pro Gln Gln 
    370                 375                 380                 


Phe Val Glu Asp Glu Asp Asp Asp Thr Phe Ser Tyr Thr Val Arg Ile 
385                 390                 395                 400 


Ala Ala Gln Asp Leu Leu Leu Ala Val Ala Thr Asp Phe Gln Asn Glu 
                405                 410                 415     


Ser Ala Ala Ala Leu Ala Ala Ala Ala Thr Arg His Leu Gln Glu Ala 
            420                 425                 430         


Glu Gln Thr Lys Asn Ser Gly Thr Glu His Trp Trp Lys Ile His Glu 
        435                 440                 445             


Ala Cys Met Leu Ala Leu Gly Ser Val Lys Ala Ile Ile Thr Asp Ser 
    450                 455                 460                 


Val Lys Asn Gly Arg Ile His Phe Asp Met His Gly Phe Leu Thr Asn 
465                 470                 475                 480 


Val Ile Leu Ala Asp Leu Asn Leu Ser Val Ser Pro Phe Leu Leu Gly 
                485                 490                 495     


Arg Ala Leu Trp Ala Ala Ser Arg Phe Thr Val Ala Met Ser Pro Glu 
            500                 505                 510         


Leu Ile Gln Gln Phe Leu Gln Ala Thr Val Ser Gly Leu His Glu Thr 
        515                 520                 525             


Gln Pro Pro Ser Val Arg Ile Ser Ala Val Arg Ala Ile Trp Gly Tyr 
    530                 535                 540                 


Cys Asp Gln Leu Lys Val Ser Glu Ser Thr His Val Leu Gln Pro Phe 
545                 550                 555                 560 


Leu Pro Ser Ile Leu Asp Gly Leu Ile His Leu Ala Ala Gln Phe Ser 
                565                 570                 575     


Ser Glu Val Leu Asn Leu Val Met Glu Thr Leu Cys Ile Val Cys Thr 
            580                 585                 590         


Val Asp Pro Glu Phe Thr Ala Ser Met Glu Ser Lys Ile Cys Pro Phe 
        595                 600                 605             


Thr Ile Ala Ile Phe Leu Lys Tyr Ser Asn Asp Pro Val Val Ala Ser 
    610                 615                 620                 


Leu Ala Gln Asp Ile Phe Lys Glu Leu Ser Gln Ile Glu Ala Cys Gln 
625                 630                 635                 640 


Gly Pro Met Gln Met Arg Leu Ile Pro Thr Leu Val Ser Ile Met Gln 
                645                 650                 655     


Ala Pro Ala Asp Lys Ile Pro Ala Gly Leu Cys Ala Thr Ala Ile Asp 
            660                 665                 670         


Ile Leu Thr Thr Val Val Arg Asn Thr Lys Pro Pro Leu Ser Gln Leu 
        675                 680                 685             


Leu Ile Cys Gln Ala Phe Pro Ala Val Ala Gln Cys Thr Leu His Thr 
    690                 695                 700                 


Asp Asp Asn Ala Thr Met Gln Asn Gly Gly Glu Cys Leu Arg Ala Tyr 
705                 710                 715                 720 


Val Ser Val Thr Leu Glu Gln Val Ala Gln Trp His Asp Glu Gln Gly 
                725                 730                 735     


His Asn Gly Leu Trp Tyr Val Met Gln Val Val Ser Gln Leu Leu Asp 
            740                 745                 750         


Pro Arg Thr Ser Glu Phe Thr Ala Ala Phe Val Gly Arg Leu Val Ser 
        755                 760                 765             


Thr Leu Ile Ser Lys Ala Gly Arg Glu Leu Gly Glu Asn Leu Asp Gln 
    770                 775                 780                 


Ile Leu Arg Ala Ile Leu Ser Lys Met Gln Gln Ala Glu Thr Leu Ser 
785                 790                 795                 800 


Val Met Gln Ser Leu Ile Met Val Phe Ala His Leu Val His Thr Gln 
                805                 810                 815     


Leu Glu Pro Leu Leu Glu Phe Leu Cys Ser Leu Pro Gly Pro Thr Gly 
            820                 825                 830         


Lys Pro Ala Leu Glu Phe Val Met Ala Glu Trp Thr Ser Arg Gln His 
        835                 840                 845             


Leu Phe Tyr Gly Gln Tyr Glu Gly Lys Val Ser Ser Val Ala Leu Cys 
    850                 855                 860                 


Lys Leu Leu Gln His Gly Ile Asn Ala Asp Asp Lys Arg Leu Gln Asp 
865                 870                 875                 880 


Ile Arg Val Lys Gly Glu Glu Ile Tyr Ser Met Asp Glu Gly Ile Arg 
                885                 890                 895     


Thr Arg Ser Lys Ser Ala Lys Asn Pro Glu Arg Trp Thr Asn Ile Pro 
            900                 905                 910         


Leu Leu Val Lys Ile Leu Lys Leu Ile Ile Asn Glu Leu Ser Asn Val 
        915                 920                 925             


Met Glu Ala Asn Ala Ala Arg Gln Ala Thr Pro Ala Glu Trp Ser Gln 
    930                 935                 940                 


Asp Asp Ser Asn Asp Met Trp Glu Asp Gln Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Glu Asp Gly Leu Ala Gly Gln Leu Leu Ser Asp Ile Leu Ala Thr 
                965                 970                 975     


Ser Lys Tyr Glu Glu Asp Tyr Tyr Glu Asp Asp Glu Glu Asp Asp Pro 
            980                 985                 990         


Asp Ala Leu Lys Asp Pro Leu Tyr  Gln Ile Asp Leu Gln  Ala Tyr Leu 
        995                 1000                 1005             


Thr Asp  Phe Leu Cys Gln Phe  Ala Gln Gln Pro Cys  Tyr Ile Met 
    1010                 1015                 1020             


Phe Ser  Gly His Leu Asn Asp  Asn Glu Arg Arg Val  Leu Gln Thr 
    1025                 1030                 1035             


Ile Gly  Ile 
    1040     


<210>  6877
<211>  4075
<212>  DNA
<213>  Homosapiens

<400>  6877
ggggctggcg ggctgagggg agaaaagatg gcggcggcgg cggcagctgg tgcggcctcc     60

gggctgccgg gtccagtggc acaaggatta aaggaagcgt tagtggatac gctcaccggg    120

atcctatccc cagtacagga ggtgcgggcg gctgctgaag aacagattaa ggtgctggag    180

gtgacggagg aatttggtgt tcacttggca gaactgactg tagatcccca gggggcactg    240

gcaatccgtc agctggcatc agtcatcttg aaacaatatg tggagactca ctggtgtgcc    300

caatcagaga aatttaggcc tcctgaaact acagaaaggg caaaaattgt tatccgggag    360

ctattgccta atgggttgag agaatcgata agcaaagtgc gctccagtgt ggcctatgca    420

gtgtcagcca ttgcccactg ggactggcct gaagcttggc cccaactctt caacctgctc    480

atggagatgt tggtgagcgg agacttaaat gccgtccatg gagccatgcg tgtgctgaca    540

gaattcactc gtgaagtaac agacacacag atgccacttg ttgctcctgt cattctccca    600

gagatgtata agatcttcac catggctgag gtgtatggta ttcgaacccg ttcccgagcc    660

gtggagattt ttaccacttg tgcccatatg atctgtaaca tggaggagct ggaaaagggt    720

gcagccaaag tcctgatctt tcccgtggta cagcagttca cagaggcctt tgttcaggcc    780

ctccagatac cagatggccc cacatctgac agtgggttta agatggaggt cctaaaggca    840

gtgacagccc tagtgaaaaa cttcccaaag cacatggtgt cctccatgca gcagattctg    900

cctattgttt ggaacaccct aaccgagagt gcagcttttt atgtgaggac agaagtaaat    960

tacacagaag aagtagaaga tcctgtggat tctgatggtg aagtcctggg ctttgaaaat   1020

ctcgtcttta gcatttttga atttgtccat gctctactag aaaatagcaa attcaaaagc   1080

actgttaaga aagccttgcc tgaattgatt tattatatta tcctgtacat gcaaatcact   1140

gaggagcaga ttaaagtatg gacagccaac ccccaacaat ttgtagaaga tgaagatgat   1200

gatacattct cctatactgt tagaatagca gctcaagact tgttgctggc tgtggccaca   1260

gatttccaga atgaaagtgc agcagccctg gctgctgcag ccactcgaca tttacaagaa   1320

gctgagcaaa ccaaaaacag tggcactgag cactggtgga agatccatga ggcatgcatg   1380

cttgccctag gctcagtgaa ggccatcatc actgacagtg tgaaaaatgg caggattcat   1440

tttgacatgc atgggttcct gaccaatgtc atccttgcag acctcaacct ctcagtgtct   1500

cctttcctct tgggccgggc actttgggct gccagtcggt tcactgttgc tatgtcccct   1560

gaactgatcc agcagttcct acaggcaaca gttagtggtc ttcacgagac acagccccca   1620

tcagttcgaa tttctgcagt gagagccatc tggggttatt gtgaccaact gaaagtctca   1680

gagagtaccc acgtgctcca gcccttcctc cccagcatcc ttgatggctt aattcaccta   1740

gcagcccagt tcagctcaga ggtcctcaac ctggtgatgg agaccctgtg catcgtttgt   1800

acagtagacc ccgaattcac agcaagcatg gaaagcaaaa tctgcccctt caccatcgcc   1860

attttcctaa agtacagtaa tgatcccgtc gtcgcctcac tggctcagga catcttcaag   1920

gagctgtccc agattgaagc ctgtcagggc ccaatgcaaa tgaggctgat tcccactctg   1980

gtcagcataa tgcaggcccc agcagacaag attcctgcag ggctttgtgc gacagccatt   2040

gatatcctga caacagtagt acgaaataca aagcctcccc tttcccagct tctcatctgc   2100

caagctttcc ctgctgtggc acagtgtacc cttcacacag atgacaatgc caccatgcag   2160

aatggcggag agtgcttgcg ggcctatgtg tcagtgaccc tggaacaagt agcccagtgg   2220

catgatgagc agggccacaa tggactgtgg tatgtgatgc aagtggtgag ccagctcctg   2280

gacccccgca cctcagagtt cactgcggcc tttgtgggcc gccttgtttc caccctcatc   2340

tccaaggcag ggcgggaact cggggagaat ctagaccaga ttcttcgtgc catcctcagt   2400

aagatgcagc aggcagagac gctcagtgtc atgcagtccc tgatcatggt gttcgctcat   2460

ctggtgcaca ctcagctaga acctctcttg gagttcctgt gtagcctccc aggacctact   2520

ggcaaacctg ctctagagtt tgtgatggct gagtggacaa gccgacagca cctgttctat   2580

ggacagtatg aaggcaaagt cagctctgtg gcactctgta agctgctcca gcatggcatc   2640

aatgcagatg acaaacggct acaggatatc cgtgtgaagg gagaggagat ctacagcatg   2700

gatgagggca tccgcacccg ctctaagtca gccaaaaacc cagaacgctg gacaaacatt   2760

cctttgctgg tcaagatcct aaagctgatc atcaacgagc tctccaacgt catggaggct   2820

aatgccgctc gccaggccac tcctgcagag tggagtcaag atgactccaa tgatatgtgg   2880

gaggaccagg aggaggaaga ggaggaggag gaggatggtt tagctggcca acttttatct   2940

gacattcttg ctacaagtaa atatgaggag gattactacg aggatgatga ggaagatgac   3000

cctgatgccc tgaaggatcc tctctatcag attgatctgc aggcatatct cacagatttc   3060

ctctgccagt ttgctcagca gccctgctac ataatgtttt caggccacct taatgacaat   3120

gagaggcgag ttctacagac catcggcatc taaaaagggg agcctttcta catttgctcc   3180

ttctgggcca gccgcaaacc attttgcagc cctcactggc cttgagatgc actttcttct   3240

caacctaaag tggcatcttg acccttggcc cttggcctcg gcagtgacac tgatgacaat   3300

tcagaccagg ctcaccggtg ccgtcactta ggaatgctgg aacaaaggac atttctcaaa   3360

gttcccctga agacatgcca tctctagaac cttttttctc cccgactcta cccccacctc   3420

tgttcctaga gccctctgct ggcgagtcca gaaacattat tgcccagaag gattatgtgt   3480

ttatggatta ttttgccccg cctcaggagc gcaggaagtc actaccattt atattctaaa   3540

acagacctat ctatgttcat aggacttctg atgtgttcag ataggaatcc tcatgagaga   3600

tcattatgct ttgtgccctg gaccactgct gctctgggtt ctcaggagga acaggcaaga   3660

gcagcttcat tctaagcctt tccagtgacc tcagccttgc ttctcttcta caacactaag   3720

gctcctctgt cagaggaggt cgtcttgttt ttgcttcatt gcatgacata acccttcccc   3780

tcaagctgtt cctatatata catgcacaca caaaataagc cagacagatg gcaatttgat   3840

cttccttttt tagaaaaaaa aaaaaaaatg gggaaaaggg atttttttta aatccacctg   3900

acccaactat atttaatatg cctctcccac acattaccac agagtctgat attcaaaggt   3960

tatccccttt ccctcaggaa gcctctaaag tgcttaagtt gtagccctca aatttgcaac   4020

atgtattttt ctaggacagt aaagtaatct ttacaaatga atttagttgc atggt        4075


<210>  6878
<211>  1041
<212>  PRT
<213>  Homosapiens

<400>  6878

Met Ala Ala Ala Ala Ala Ala Gly Ala Ala Ser Gly Leu Pro Gly Pro 
1               5                   10                  15      


Val Ala Gln Gly Leu Lys Glu Ala Leu Val Asp Thr Leu Thr Gly Ile 
            20                  25                  30          


Leu Ser Pro Val Gln Glu Val Arg Ala Ala Ala Glu Glu Gln Ile Lys 
        35                  40                  45              


Val Leu Glu Val Thr Glu Glu Phe Gly Val His Leu Ala Glu Leu Thr 
    50                  55                  60                  


Val Asp Pro Gln Gly Ala Leu Ala Ile Arg Gln Leu Ala Ser Val Ile 
65                  70                  75                  80  


Leu Lys Gln Tyr Val Glu Thr His Trp Cys Ala Gln Ser Glu Lys Phe 
                85                  90                  95      


Arg Pro Pro Glu Thr Thr Glu Arg Ala Lys Ile Val Ile Arg Glu Leu 
            100                 105                 110         


Leu Pro Asn Gly Leu Arg Glu Ser Ile Ser Lys Val Arg Ser Ser Val 
        115                 120                 125             


Ala Tyr Ala Val Ser Ala Ile Ala His Trp Asp Trp Pro Glu Ala Trp 
    130                 135                 140                 


Pro Gln Leu Phe Asn Leu Leu Met Glu Met Leu Val Ser Gly Asp Leu 
145                 150                 155                 160 


Asn Ala Val His Gly Ala Met Arg Val Leu Thr Glu Phe Thr Arg Glu 
                165                 170                 175     


Val Thr Asp Thr Gln Met Pro Leu Val Ala Pro Val Ile Leu Pro Glu 
            180                 185                 190         


Met Tyr Lys Ile Phe Thr Met Ala Glu Val Tyr Gly Ile Arg Thr Arg 
        195                 200                 205             


Ser Arg Ala Val Glu Ile Phe Thr Thr Cys Ala His Met Ile Cys Asn 
    210                 215                 220                 


Met Glu Glu Leu Glu Lys Gly Ala Ala Lys Val Leu Ile Phe Pro Val 
225                 230                 235                 240 


Val Gln Gln Phe Thr Glu Ala Phe Val Gln Ala Leu Gln Ile Pro Asp 
                245                 250                 255     


Gly Pro Thr Ser Asp Ser Gly Phe Lys Met Glu Val Leu Lys Ala Val 
            260                 265                 270         


Thr Ala Leu Val Lys Asn Phe Pro Lys His Met Val Ser Ser Met Gln 
        275                 280                 285             


Gln Ile Leu Pro Ile Val Trp Asn Thr Leu Thr Glu Ser Ala Ala Phe 
    290                 295                 300                 


Tyr Val Arg Thr Glu Val Asn Tyr Thr Glu Glu Val Glu Asp Pro Val 
305                 310                 315                 320 


Asp Ser Asp Gly Glu Val Leu Gly Phe Glu Asn Leu Val Phe Ser Ile 
                325                 330                 335     


Phe Glu Phe Val His Ala Leu Leu Glu Asn Ser Lys Phe Lys Ser Thr 
            340                 345                 350         


Val Lys Lys Ala Leu Pro Glu Leu Ile Tyr Tyr Ile Ile Leu Tyr Met 
        355                 360                 365             


Gln Ile Thr Glu Glu Gln Ile Lys Val Trp Thr Ala Asn Pro Gln Gln 
    370                 375                 380                 


Phe Val Glu Asp Glu Asp Asp Asp Thr Phe Ser Tyr Thr Val Arg Ile 
385                 390                 395                 400 


Ala Ala Gln Asp Leu Leu Leu Ala Val Ala Thr Asp Phe Gln Asn Glu 
                405                 410                 415     


Ser Ala Ala Ala Leu Ala Ala Ala Ala Thr Arg His Leu Gln Glu Ala 
            420                 425                 430         


Glu Gln Thr Lys Asn Ser Gly Thr Glu His Trp Trp Lys Ile His Glu 
        435                 440                 445             


Ala Cys Met Leu Ala Leu Gly Ser Val Lys Ala Ile Ile Thr Asp Ser 
    450                 455                 460                 


Val Lys Asn Gly Arg Ile His Phe Asp Met His Gly Phe Leu Thr Asn 
465                 470                 475                 480 


Val Ile Leu Ala Asp Leu Asn Leu Ser Val Ser Pro Phe Leu Leu Gly 
                485                 490                 495     


Arg Ala Leu Trp Ala Ala Ser Arg Phe Thr Val Ala Met Ser Pro Glu 
            500                 505                 510         


Leu Ile Gln Gln Phe Leu Gln Ala Thr Val Ser Gly Leu His Glu Thr 
        515                 520                 525             


Gln Pro Pro Ser Val Arg Ile Ser Ala Val Arg Ala Ile Trp Gly Tyr 
    530                 535                 540                 


Cys Asp Gln Leu Lys Val Ser Glu Ser Thr His Val Leu Gln Pro Phe 
545                 550                 555                 560 


Leu Pro Ser Ile Leu Asp Gly Leu Ile His Leu Ala Ala Gln Phe Ser 
                565                 570                 575     


Ser Glu Val Leu Asn Leu Val Met Glu Thr Leu Cys Ile Val Cys Thr 
            580                 585                 590         


Val Asp Pro Glu Phe Thr Ala Ser Met Glu Ser Lys Ile Cys Pro Phe 
        595                 600                 605             


Thr Ile Ala Ile Phe Leu Lys Tyr Ser Asn Asp Pro Val Val Ala Ser 
    610                 615                 620                 


Leu Ala Gln Asp Ile Phe Lys Glu Leu Ser Gln Ile Glu Ala Cys Gln 
625                 630                 635                 640 


Gly Pro Met Gln Met Arg Leu Ile Pro Thr Leu Val Ser Ile Met Gln 
                645                 650                 655     


Ala Pro Ala Asp Lys Ile Pro Ala Gly Leu Cys Ala Thr Ala Ile Asp 
            660                 665                 670         


Ile Leu Thr Thr Val Val Arg Asn Thr Lys Pro Pro Leu Ser Gln Leu 
        675                 680                 685             


Leu Ile Cys Gln Ala Phe Pro Ala Val Ala Gln Cys Thr Leu His Thr 
    690                 695                 700                 


Asp Asp Asn Ala Thr Met Gln Asn Gly Gly Glu Cys Leu Arg Ala Tyr 
705                 710                 715                 720 


Val Ser Val Thr Leu Glu Gln Val Ala Gln Trp His Asp Glu Gln Gly 
                725                 730                 735     


His Asn Gly Leu Trp Tyr Val Met Gln Val Val Ser Gln Leu Leu Asp 
            740                 745                 750         


Pro Arg Thr Ser Glu Phe Thr Ala Ala Phe Val Gly Arg Leu Val Ser 
        755                 760                 765             


Thr Leu Ile Ser Lys Ala Gly Arg Glu Leu Gly Glu Asn Leu Asp Gln 
    770                 775                 780                 


Ile Leu Arg Ala Ile Leu Ser Lys Met Gln Gln Ala Glu Thr Leu Ser 
785                 790                 795                 800 


Val Met Gln Ser Leu Ile Met Val Phe Ala His Leu Val His Thr Gln 
                805                 810                 815     


Leu Glu Pro Leu Leu Glu Phe Leu Cys Ser Leu Pro Gly Pro Thr Gly 
            820                 825                 830         


Lys Pro Ala Leu Glu Phe Val Met Ala Glu Trp Thr Ser Arg Gln His 
        835                 840                 845             


Leu Phe Tyr Gly Gln Tyr Glu Gly Lys Val Ser Ser Val Ala Leu Cys 
    850                 855                 860                 


Lys Leu Leu Gln His Gly Ile Asn Ala Asp Asp Lys Arg Leu Gln Asp 
865                 870                 875                 880 


Ile Arg Val Lys Gly Glu Glu Ile Tyr Ser Met Asp Glu Gly Ile Arg 
                885                 890                 895     


Thr Arg Ser Lys Ser Ala Lys Asn Pro Glu Arg Trp Thr Asn Ile Pro 
            900                 905                 910         


Leu Leu Val Lys Ile Leu Lys Leu Ile Ile Asn Glu Leu Ser Asn Val 
        915                 920                 925             


Met Glu Ala Asn Ala Ala Arg Gln Ala Thr Pro Ala Glu Trp Ser Gln 
    930                 935                 940                 


Asp Asp Ser Asn Asp Met Trp Glu Asp Gln Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Glu Asp Gly Leu Ala Gly Gln Leu Leu Ser Asp Ile Leu Ala Thr 
                965                 970                 975     


Ser Lys Tyr Glu Glu Asp Tyr Tyr Glu Asp Asp Glu Glu Asp Asp Pro 
            980                 985                 990         


Asp Ala Leu Lys Asp Pro Leu Tyr  Gln Ile Asp Leu Gln  Ala Tyr Leu 
        995                 1000                 1005             


Thr Asp  Phe Leu Cys Gln Phe  Ala Gln Gln Pro Cys  Tyr Ile Met 
    1010                 1015                 1020             


Phe Ser  Gly His Leu Asn Asp  Asn Glu Arg Arg Val  Leu Gln Thr 
    1025                 1030                 1035             


Ile Gly  Ile 
    1040     


<210>  6879
<211>  6050
<212>  DNA
<213>  Homosapiens

<400>  6879
ggggctggcg ggctgagggg agaaaagatg gcggcggcgg cggcagctgg tgcggcctcc     60

gggctgccgg gtccagtggc acaaggatta aaggaagcgt tagtggatac gctcaccggg    120

atcctatccc cagtacagga ggtgcgggcg gctgctgaag aacagattaa ggtgctggag    180

gtgacggagg aatttggtgt tcacttggca gaactgactg tagatcccca gggggcactg    240

gcaatccgtc agctggcatc agtcatcttg aaacaatatg tggagactca ctggtgtgcc    300

caatcagaga aatttaggcc tcctgaaact acagaaaggg caaaaattgt tatccgggag    360

ctattgccta atgggttgag agaatcgata agcaaagtgc gctccagtgt ggcctatgca    420

gtgtcagcca ttgcccactg ggactggcct gaagcttggc cccaactctt caacctgctc    480

atggagatgt tggtgagcgg agacttaaat gccgtccatg gagccatgcg tgtgctgaca    540

gaattcactc gtgaagtaac agacacacag atgccacttg ttgctcctgt cattctccca    600

gagatgtata agatcttcac catggctgag gtgtatggta ttcgaacccg ttcccgagcc    660

gtggagattt ttaccacttg tgcccatatg atctgtaaca tggaggagct ggaaaagggt    720

gcagccaaag tcctgatctt tcccgtggta cagcagttca cagaggcctt tgttcaggcc    780

ctccagatac cagatggccc cacatctgac agtgggttta agatggaggt cctaaaggca    840

gtgacagccc tagtgaaaaa cttcccaaag cacatggtgt cctccatgca gcagattctg    900

cctattgttt ggaacaccct aaccgagagt gcagcttttt atgtgaggac agaagtaaat    960

tacacagaag aagtagaaga tcctgtggat tctgatggtg aagtcctggg ctttgaaaat   1020

ctcgtcttta gcatttttga atttgtccat gctctactag aaaatagcaa attcaaaagc   1080

actgttaaga aagccttgcc tgaattgatt tattatatta tcctgtacat gcaaatcact   1140

gaggagcaga ttaaagtatg gacagccaac ccccaacaat ttgtagaaga tgaagatgat   1200

gatacattct cctatactgt tagaatagca gctcaagact tgttgctggc tgtggccaca   1260

gatttccaga atgaaagtgc agcagccctg gctgctgcag ccactcgaca tttacaagaa   1320

gctgagcaaa ccaaaaacag tggcactgag cactggtgga agatccatga ggcatgcatg   1380

cttgccctag gctcagtgaa ggccatcatc actgacagtg tgaaaaatgg caggattcat   1440

tttgacatgc atgggttcct gaccaatgtc atccttgcag acctcaacct ctcagtgtct   1500

cctttcctct tgggccgggc actttgggct gccagtcggt tcactgttgc tatgtcccct   1560

gaactgatcc agcagttcct acaggcaaca gttagtggtc ttcacgagac acagccccca   1620

tcagttcgaa tttctgcagt gagagccatc tggggttatt gtgaccaact gaaagtctca   1680

gagagtaccc acgtgctcca gcccttcctc cccagcatcc ttgatggctt aattcaccta   1740

gcagcccagt tcagctcaga ggtcctcaac ctggtgatgg agaccctgtg catcgtttgt   1800

acagtagacc ccgaattcac agcaagcatg gaaagcaaaa tctgcccctt caccatcgcc   1860

attttcctaa agtacagtaa tgatcccgtc gtcgcctcac tggctcagga catcttcaag   1920

gagctgtccc agattgaagc ctgtcagggc ccaatgcaaa tgaggctgat tcccactctg   1980

gtcagcataa tgcaggcccc agcagacaag attcctgcag ggctttgtgc gacagccatt   2040

gatatcctga caacagtagt acgaaataca aagcctcccc tttcccagct tctcatctgc   2100

caagctttcc ctgctgtggc acagtgtacc cttcacacag atgacaatgc caccatgcag   2160

aatggcggag agtgcttgcg ggcctatgtg tcagtgaccc tggaacaagt agcccagtgg   2220

catgatgagc agggccacaa tggactgtgg tatgtgatgc aagtggtgag ccagctcctg   2280

gacccccgca cctcagagtt cactgcggcc tttgtgggcc gccttgtttc caccctcatc   2340

tccaaggcag ggcgggaact cggggagaat ctagaccaga ttcttcgtgc catcctcagt   2400

aagatgcagc aggcagagac gctcagtgtc atgcagtccc tgatcatggt gttcgctcat   2460

ctggtgcaca ctcagctaga acctctcttg gagttcctgt gtagcctccc aggacctact   2520

ggcaaacctg ctctagagtt tgtgatggct gagtggacaa gccgacagca cctgttctat   2580

ggacagtatg aaggcaaagt cagctctgtg gcactctgta agctgctcca gcatggcatc   2640

aatgcagatg acaaacggct acaggatatc cgtgtgaagg gagaggagat ctacagcatg   2700

gatgagggca tccgcacccg ctctaagtca gccaaaaacc cagaacgctg gacaaacatt   2760

cctttgctgg tcaagatcct aaagctgatc atcaacgagc tctccaacgt catggaggct   2820

aatgccgctc gccaggccac tcctgcagag tggagtcaag atgactccaa tgatatgtgg   2880

gaggaccagg aggaggaaga ggaggaggag gaggatggtt tagctggcca acttttatct   2940

gacattcttg ctacaagtaa atatgaggag gattactacg aggatgatga ggaagatgac   3000

cctgatgccc tgaaggatcc tctctatcag attgatctgc aggcatatct cacagatttc   3060

ctctgccagt ttgctcagca gccctgctac ataatgtttt caggccacct taatgacaat   3120

gagaggcgag ttctacagac catcggcatc taaaaagggg agcctttcta catttgctcc   3180

ttctgggcca gccgcaaacc attttgcagc cctcactggc cttgagatgc actttcttct   3240

caacctaaag tggcatcttg acccttggcc cttggcctcg gcagtgacac tgatgacaat   3300

tcagaccagg ctcaccggtg ccgtcactta ggaatgctgg aacaaaggac atttctcaaa   3360

gttcccctga agacatgcca tctctagaac cttttttctc cccgactcta cccccacctc   3420

tgttcctaga gccctctgct ggcgagtcca gaaacattat tgcccagaag gattatgtgt   3480

ttatggatta ttttgccccg cctcaggagc gcaggaagtc actaccattt atattctaaa   3540

acagacctat ctatgttcat aggacttctg atgtgttcag ataggaatcc tcatgagaga   3600

tcattatgct ttgtgccctg gaccactgct gctctgggtt ctcaggagga acaggcaaga   3660

gcagcttcat tctaagcctt tccagtgacc tcagccttgc ttctcttcta caacactaag   3720

gctcctctgt cagaggaggt cgtcttgttt ttgcttcatt gcatgacata acccttcccc   3780

tcaagctgtt cctatatata catgcacaca caaaataagc cagacagatg gcaatttgat   3840

cttccttttt tagaaaaaaa aaaaaaaatg gggaaaaggg atttttttta aatccacctg   3900

acccaactat atttaatatg cctctcccac acattaccac agagtctgat attcaaaggt   3960

tatccccttt ccctcaggaa gcctctaaag tgcttaagtt gtagccctca aatttgcaac   4020

atgtattttt ctaggacagt aaagtaatct ttacaaatga atttagttgc atggtataag   4080

gtgtctcagc acctgtttgc cttctattcc ctttagaagg taagtaaaag taatggggga   4140

aaggattagg tggagcctgt ctaaacattc tagtgtgtct tggcaaacat agcctgaaat   4200

gattcttaaa gaactggcat tgtttaatca aatattttta agggagattc cttaattggg   4260

aagtttagtc tgtttggggt tcaaagagta aatgaggatt agaaaatcat ggagagaggc   4320

tgggcgcggt ggctaacgcc tgtaatccta gcactttggg aggctgagat gggcggatca   4380

cttgagatca ggagtttgag gctagcctgg ccaacacagt gaaacctgca tttctactaa   4440

aaatacaaaa attagctggg catggtggtg catgcctgta atcccagtta acttgagatg   4500

ctgaggcagg agaatcgctt gaacttggga agcagaggtt gcagtgaacc gatatcacac   4560

cgttgcattc caaggcaaga ctcaatcaca cacacacaca cacacacaca caaatcatgg   4620

ggagaaagat gaaacctgtg ttcccctttt tttggtagtg cccacatctg gtgccccatt   4680

tttaataacc acaggatatt tctttagatt gatattctca caaagaagaa atagaatata   4740

ggctgggcgt ggtgtgtcac acctgtaatc ccagcactta cggaggccga agccagcgga   4800

tcaccagagg tcaggagttc gagaccagcc tgaccaacat gatgaaaccc tgtctctact   4860

aaaaatacaa aaattagcca ggcatggtgg catgcacttg taatcccagc tactcgggag   4920

gctgagacag gagaatcgct tgaacctggg aggcagaggt tgcagtaagc caagatcgca   4980

ccattgcact acagcctggg caacaagagg agcgaaactc tgtctcaaaa aaaaaaaaga   5040

gaaagaatat aaagtgaatc tgaatctcca ctcaagggga tggccccaag gatattgtag   5100

ctggtaattt cttcatgcca ctaggtgtcc ccagtgttca acctccatga ctgagattgg   5160

aagaagtaga gttaaaagtt tttactacct ttgagaagcc tgcgggcatg ttcacagtcg   5220

tcccatgcca gccaggttct gaggctaact gcttgtgccc ctgctgcttc acatggcatt   5280

gtgggagttg ctgatactgg ggaaatgatg gcagatctga ccaagtggtg ctgagaaaac   5340

caccctcggc cttgcagact ccatagttta tctcaaggca gtgccagtcg gatttggtgc   5400

taaaggcata aggccaagtc agcctctgat attggcacaa aagaatggtc tcatgccagt   5460

agcattgaac tgctgagctt gggaaggctt aaggctccca cacacagact gagaatgatg   5520

ggggtccctc tgcgtctgct aattagacaa acattctata tctagtgcca aaagtggtcc   5580

taaatccttt ggcaagggtc ctttctgctc tcatgctgat ttgggggagg actgggcatc   5640

ctgcctcagg agaacttgag tcctgaggaa agggccctag taacacttaa gggctacccc   5700

tggctaacag atactcggct gtgggtgaga gcagaaggtc ttggacccct cgatgtgcag   5760

gtacttaatt gtgtttccag tgcattttca tatacattat cccatttaac ctttataaca   5820

ggttcacaga gtggatattc ccattctgtt gatgagaaaa agagtggaga gactgtgtcc   5880

agtgtcagca ggaagaaaaa agatctgttg gaggccagta catgttgaca gaaactctag   5940

accatatttt gtctcctgtc tttggccaaa gagaactagc ttcagtctga aaagggcagg   6000

gctaagtggt tacaaggaac taaaaagttc aaggtaagac aaatgaggta              6050


<210>  6880
<211>  1041
<212>  PRT
<213>  Homosapiens

<400>  6880

Met Ala Ala Ala Ala Ala Ala Gly Ala Ala Ser Gly Leu Pro Gly Pro 
1               5                   10                  15      


Val Ala Gln Gly Leu Lys Glu Ala Leu Val Asp Thr Leu Thr Gly Ile 
            20                  25                  30          


Leu Ser Pro Val Gln Glu Val Arg Ala Ala Ala Glu Glu Gln Ile Lys 
        35                  40                  45              


Val Leu Glu Val Thr Glu Glu Phe Gly Val His Leu Ala Glu Leu Thr 
    50                  55                  60                  


Val Asp Pro Gln Gly Ala Leu Ala Ile Arg Gln Leu Ala Ser Val Ile 
65                  70                  75                  80  


Leu Lys Gln Tyr Val Glu Thr His Trp Cys Ala Gln Ser Glu Lys Phe 
                85                  90                  95      


Arg Pro Pro Glu Thr Thr Glu Arg Ala Lys Ile Val Ile Arg Glu Leu 
            100                 105                 110         


Leu Pro Asn Gly Leu Arg Glu Ser Ile Ser Lys Val Arg Ser Ser Val 
        115                 120                 125             


Ala Tyr Ala Val Ser Ala Ile Ala His Trp Asp Trp Pro Glu Ala Trp 
    130                 135                 140                 


Pro Gln Leu Phe Asn Leu Leu Met Glu Met Leu Val Ser Gly Asp Leu 
145                 150                 155                 160 


Asn Ala Val His Gly Ala Met Arg Val Leu Thr Glu Phe Thr Arg Glu 
                165                 170                 175     


Val Thr Asp Thr Gln Met Pro Leu Val Ala Pro Val Ile Leu Pro Glu 
            180                 185                 190         


Met Tyr Lys Ile Phe Thr Met Ala Glu Val Tyr Gly Ile Arg Thr Arg 
        195                 200                 205             


Ser Arg Ala Val Glu Ile Phe Thr Thr Cys Ala His Met Ile Cys Asn 
    210                 215                 220                 


Met Glu Glu Leu Glu Lys Gly Ala Ala Lys Val Leu Ile Phe Pro Val 
225                 230                 235                 240 


Val Gln Gln Phe Thr Glu Ala Phe Val Gln Ala Leu Gln Ile Pro Asp 
                245                 250                 255     


Gly Pro Thr Ser Asp Ser Gly Phe Lys Met Glu Val Leu Lys Ala Val 
            260                 265                 270         


Thr Ala Leu Val Lys Asn Phe Pro Lys His Met Val Ser Ser Met Gln 
        275                 280                 285             


Gln Ile Leu Pro Ile Val Trp Asn Thr Leu Thr Glu Ser Ala Ala Phe 
    290                 295                 300                 


Tyr Val Arg Thr Glu Val Asn Tyr Thr Glu Glu Val Glu Asp Pro Val 
305                 310                 315                 320 


Asp Ser Asp Gly Glu Val Leu Gly Phe Glu Asn Leu Val Phe Ser Ile 
                325                 330                 335     


Phe Glu Phe Val His Ala Leu Leu Glu Asn Ser Lys Phe Lys Ser Thr 
            340                 345                 350         


Val Lys Lys Ala Leu Pro Glu Leu Ile Tyr Tyr Ile Ile Leu Tyr Met 
        355                 360                 365             


Gln Ile Thr Glu Glu Gln Ile Lys Val Trp Thr Ala Asn Pro Gln Gln 
    370                 375                 380                 


Phe Val Glu Asp Glu Asp Asp Asp Thr Phe Ser Tyr Thr Val Arg Ile 
385                 390                 395                 400 


Ala Ala Gln Asp Leu Leu Leu Ala Val Ala Thr Asp Phe Gln Asn Glu 
                405                 410                 415     


Ser Ala Ala Ala Leu Ala Ala Ala Ala Thr Arg His Leu Gln Glu Ala 
            420                 425                 430         


Glu Gln Thr Lys Asn Ser Gly Thr Glu His Trp Trp Lys Ile His Glu 
        435                 440                 445             


Ala Cys Met Leu Ala Leu Gly Ser Val Lys Ala Ile Ile Thr Asp Ser 
    450                 455                 460                 


Val Lys Asn Gly Arg Ile His Phe Asp Met His Gly Phe Leu Thr Asn 
465                 470                 475                 480 


Val Ile Leu Ala Asp Leu Asn Leu Ser Val Ser Pro Phe Leu Leu Gly 
                485                 490                 495     


Arg Ala Leu Trp Ala Ala Ser Arg Phe Thr Val Ala Met Ser Pro Glu 
            500                 505                 510         


Leu Ile Gln Gln Phe Leu Gln Ala Thr Val Ser Gly Leu His Glu Thr 
        515                 520                 525             


Gln Pro Pro Ser Val Arg Ile Ser Ala Val Arg Ala Ile Trp Gly Tyr 
    530                 535                 540                 


Cys Asp Gln Leu Lys Val Ser Glu Ser Thr His Val Leu Gln Pro Phe 
545                 550                 555                 560 


Leu Pro Ser Ile Leu Asp Gly Leu Ile His Leu Ala Ala Gln Phe Ser 
                565                 570                 575     


Ser Glu Val Leu Asn Leu Val Met Glu Thr Leu Cys Ile Val Cys Thr 
            580                 585                 590         


Val Asp Pro Glu Phe Thr Ala Ser Met Glu Ser Lys Ile Cys Pro Phe 
        595                 600                 605             


Thr Ile Ala Ile Phe Leu Lys Tyr Ser Asn Asp Pro Val Val Ala Ser 
    610                 615                 620                 


Leu Ala Gln Asp Ile Phe Lys Glu Leu Ser Gln Ile Glu Ala Cys Gln 
625                 630                 635                 640 


Gly Pro Met Gln Met Arg Leu Ile Pro Thr Leu Val Ser Ile Met Gln 
                645                 650                 655     


Ala Pro Ala Asp Lys Ile Pro Ala Gly Leu Cys Ala Thr Ala Ile Asp 
            660                 665                 670         


Ile Leu Thr Thr Val Val Arg Asn Thr Lys Pro Pro Leu Ser Gln Leu 
        675                 680                 685             


Leu Ile Cys Gln Ala Phe Pro Ala Val Ala Gln Cys Thr Leu His Thr 
    690                 695                 700                 


Asp Asp Asn Ala Thr Met Gln Asn Gly Gly Glu Cys Leu Arg Ala Tyr 
705                 710                 715                 720 


Val Ser Val Thr Leu Glu Gln Val Ala Gln Trp His Asp Glu Gln Gly 
                725                 730                 735     


His Asn Gly Leu Trp Tyr Val Met Gln Val Val Ser Gln Leu Leu Asp 
            740                 745                 750         


Pro Arg Thr Ser Glu Phe Thr Ala Ala Phe Val Gly Arg Leu Val Ser 
        755                 760                 765             


Thr Leu Ile Ser Lys Ala Gly Arg Glu Leu Gly Glu Asn Leu Asp Gln 
    770                 775                 780                 


Ile Leu Arg Ala Ile Leu Ser Lys Met Gln Gln Ala Glu Thr Leu Ser 
785                 790                 795                 800 


Val Met Gln Ser Leu Ile Met Val Phe Ala His Leu Val His Thr Gln 
                805                 810                 815     


Leu Glu Pro Leu Leu Glu Phe Leu Cys Ser Leu Pro Gly Pro Thr Gly 
            820                 825                 830         


Lys Pro Ala Leu Glu Phe Val Met Ala Glu Trp Thr Ser Arg Gln His 
        835                 840                 845             


Leu Phe Tyr Gly Gln Tyr Glu Gly Lys Val Ser Ser Val Ala Leu Cys 
    850                 855                 860                 


Lys Leu Leu Gln His Gly Ile Asn Ala Asp Asp Lys Arg Leu Gln Asp 
865                 870                 875                 880 


Ile Arg Val Lys Gly Glu Glu Ile Tyr Ser Met Asp Glu Gly Ile Arg 
                885                 890                 895     


Thr Arg Ser Lys Ser Ala Lys Asn Pro Glu Arg Trp Thr Asn Ile Pro 
            900                 905                 910         


Leu Leu Val Lys Ile Leu Lys Leu Ile Ile Asn Glu Leu Ser Asn Val 
        915                 920                 925             


Met Glu Ala Asn Ala Ala Arg Gln Ala Thr Pro Ala Glu Trp Ser Gln 
    930                 935                 940                 


Asp Asp Ser Asn Asp Met Trp Glu Asp Gln Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Glu Asp Gly Leu Ala Gly Gln Leu Leu Ser Asp Ile Leu Ala Thr 
                965                 970                 975     


Ser Lys Tyr Glu Glu Asp Tyr Tyr Glu Asp Asp Glu Glu Asp Asp Pro 
            980                 985                 990         


Asp Ala Leu Lys Asp Pro Leu Tyr  Gln Ile Asp Leu Gln  Ala Tyr Leu 
        995                 1000                 1005             


Thr Asp  Phe Leu Cys Gln Phe  Ala Gln Gln Pro Cys  Tyr Ile Met 
    1010                 1015                 1020             


Phe Ser  Gly His Leu Asn Asp  Asn Glu Arg Arg Val  Leu Gln Thr 
    1025                 1030                 1035             


Ile Gly  Ile 
    1040     


<210>  6881
<211>  719
<212>  DNA
<213>  Homosapiens

<400>  6881
agaatttggt gttcacttgg cagaactgac tgtagatccc cagggggcac tggcaatccg     60

tcagctggca tcagtcatct tgaaacaata tgtggagact cactggtgtg cccaatcaga    120

gaaatttagg cctcctgaaa ctacagaaag ggcaaaaatt gttatccggg agctattgcc    180

taatgggttg agagaatcga taagcaaagt gcgctccagt gtggcctatg cagtgtcagc    240

cattgcccac tgggactggc ctgaagcttg gccccaactc ttcaacctgc tcatggagat    300

gttggtgagc ggagacttaa atgccgtcca tggagccatg cgtgtgctga cagatgagaa    360

ccaactaagg ctcatggtgt aaaggaaatg caaatatagc agctaaggat tagaagattt    420

gatccaccag atacagcttt ttcttcgttc tcaaagaagt ttggagattg agatgttgct    480

ggagtcctag aatttttctg acttgctgaa tcacctcaga aaacttttgg aattaaacct    540

ataaagtatt aataaattga taccagggat gagtatagga gagtaaaaag cagtcaagca    600

ctttattagc agaattaaat tatactgtat ttttcataaa acttgttatt atgccatcta    660

tcatatttgt ttggactaat ttccttgaat ttctaaataa aatagaacac tcaccattc     719


<210>  6882
<211>  33
<212>  PRT
<213>  Homosapiens

<400>  6882

Met Trp Arg Leu Thr Gly Val Pro Asn Gln Arg Asn Leu Gly Leu Leu 
1               5                   10                  15      


Lys Leu Gln Lys Gly Gln Lys Leu Leu Ser Gly Ser Tyr Cys Leu Met 
            20                  25                  30          


Gly 
    


<210>  6883
<211>  2852
<212>  DNA
<213>  Homosapiens

<400>  6883
ggctgcagtg agctgtgatc ataccactgc actcgagcct gggcgacaaa gcaagaccct     60

gtgttcaaaa aaaaaaaaaa atccatttat aatttaacat gggagcctca tgggaaagag    120

ttcctgtctt gttgagtggt ccagggtttt gggtgggctg gaactttgca cttgatgtgt    180

tgtaattcat cttctagagg ctatgttgtg aaggtccttg gggtgataca gccttggaaa    240

aatgttgttt ccctgtggat tacctaaact agatccaaga acatgaaaga ccatccctca    300

gggagctggc atttgtctaa aaaccagcat tccctgtgcc atttgattgt ggttcttgct    360

ccactgcaaa tgggtgactt gcaatgtctc actaatgcca ctcttgctct ttcctccagg    420

catatctcac agatttcctc tgccagtttg ctcagcagcc ctgctacata atgttttcag    480

gccaccttaa tgacaatgag aggcgagttc tacagaccat cggcatctct gtcagaggag    540

gtcgtcttgt ttttgcttca ttgcatgaca taacccttcc cctcaagctg ttcctatata    600

tacatgcaca cacaaaataa gccagacaga tggcaatttg atcttccttt tttagaaaaa    660

aaaaaaaaaa tggggaaaag ggattttttt taaatccacc tgacccaact atatttaata    720

tgcctctccc acacattacc acagagtctg atattcaaag gttatcccct ttccctcagg    780

aagcctctaa agtgcttaag ttgtagccct caaatttgca acatgtattt ttctaggaca    840

gtaaagtaat ctttacaaat gaatttagtt gcatggtata aggtgtctca gcacctgttt    900

gccttctatt ccctttagaa ggtaagtaaa agtaatgggg gaaaggatta ggtggagcct    960

gtctaaacat tctagtgtgt cttggcaaac atagcctgaa atgattctta aagaactggc   1020

attgtttaat caaatatttt taagggagat tccttaattg ggaagtttag tctgtttggg   1080

gttcaaagag taaatgagga ttagaaaatc atggagagag gctgggcgcg gtggctaacg   1140

cctgtaatcc tagcactttg ggaggctgag atgggcggat cacttgagat caggagtttg   1200

aggctagcct ggccaacaca gtgaaacctg catttctact aaaaatacaa aaattagctg   1260

ggcatggtgg tgcatgcctg taatcccagt taacttgaga tgctgaggca ggagaatcgc   1320

ttgaacttgg gaagcagagg ttgcagtgaa ccgatatcac accgttgcat tccaaggcaa   1380

gactcaatca cacacacaca cacacacaca cacaaatcat ggggagaaag atgaaacctg   1440

tgttcccctt tttttggtag tgcccacatc tggtgcccca tttttaataa ccacaggata   1500

tttctttaga ttgatattct cacaaagaag aaatagaata taggctgggc gtggtgtgtc   1560

acacctgtaa tcccagcact tacggaggcc gaagccagcg gatcaccaga ggtcaggagt   1620

tcgagaccag cctgaccaac atgatgaaac cctgtctcta ctaaaaatac aaaaattagc   1680

caggcatggt ggcatgcact tgtaatccca gctactcggg aggctgagac aggagaatcg   1740

cttgaacctg ggaggcagag gttgcagtaa gccaagatcg caccattgca ctacagcctg   1800

ggcaacaaga ggagcgaaac tctgtctcaa aaaaaaaaaa gagaaagaat ataaagtgaa   1860

tctgaatctc cactcaaggg gatggcccca aggatattgt agctggtaat ttcttcatgc   1920

cactaggtgt ccccagtgtt caacctccat gactgagatt ggaagaagta gagttaaaag   1980

tttttactac ctttgagaag cctgcgggca tgttcacagt cgtcccatgc cagccaggtt   2040

ctgaggctaa ctgcttgtgc ccctgctgct tcacatggca ttgtgggagt tgctgatact   2100

ggggaaatga tggcagatct gaccaagtgg tgctgagaaa accaccctcg gccttgcaga   2160

ctccatagtt tatctcaagg cagtgccagt cggatttggt gctaaaggca taaggccaag   2220

tcagcctctg atattggcac aaaagaatgg tctcatgcca gtagcattga actgctgagc   2280

ttgggaaggc ttaaggctcc cacacacaga ctgagaatga tgggggtccc tctgcgtctg   2340

ctaattagac aaacattcta tatctagtgc caaaagtggt cctaaatcct ttggcaaggg   2400

tcctttctgc tctcatgctg atttggggga ggactgggca tcctgcctca ggagaacttg   2460

agtcctgagg aaagggccct agtaacactt aagggctacc cctggctaac agatactcgg   2520

ctgtgggtga gagcagaagg tcttggaccc ctcgatgtgc aggtacttaa ttgtgtttcc   2580

agtgcatttt catatacatt atcccattta acctttataa caggttcaca gagtggatat   2640

tcccattctg ttgatgagaa aaagagtgga gagactgtgt ccagtgtcag caggaagaaa   2700

aaagatctgt tggaggccag tacatgttga cagaaactct agaccatatt ttgtctcctg   2760

tctttggcca aagagaacta gcttcagtct gaaaagggca gggctaagtg gttacaagga   2820

actaaaaagt tcaaggtaag acaaatgagg ta                                 2852


<210>  6884
<211>  49
<212>  PRT
<213>  Homosapiens

<400>  6884

Met Phe Ser Gly His Leu Asn Asp Asn Glu Arg Arg Val Leu Gln Thr 
1               5                   10                  15      


Ile Gly Ile Ser Val Arg Gly Gly Arg Leu Val Phe Ala Ser Leu His 
            20                  25                  30          


Asp Ile Thr Leu Pro Leu Lys Leu Phe Leu Tyr Ile His Ala His Thr 
        35                  40                  45              


Lys 
    


<210>  6885
<211>  1313
<212>  DNA
<213>  Homosapiens

<400>  6885
gacgcggcag aggaggtccc ccacaagtga aggtccagcc ctgctcctcc agggttggcc     60

catgtgtctg ggcattcgga ggtggcacca ggatcagggc ttctggagtc cagcatagtg    120

attgggccca ggccgggggc gggtccagga cacagccagg cttccctggc cgcagtgccc    180

aactgcccgc agtgcccatg gtggctcgga tgggaggaac caccgcggag ccggggacag    240

ggggagcagg gcagtgctct gctgggtgag gggcacccag ctccagaggc taggtgggcg    300

tcgctggtgg gtggactcct gggcgctgcg cggagccgcg ccggctgggt tagcgcgggc    360

ggggcgctta gtcccacccc cagaggaggc ggaagaggag cccgagcctg gccgcgggct    420

gggccccgcc gcagctccag ctggccggct tggtcctgcg gtcccttctc tgggaggccc    480

gaccccggcc gcgcccagcc cccaccatgc cacccgcggg gctccgccgg gccgcgccgc    540

tcaccgcaat cgctctgttg gtgctggggg ctcccctggt gctggccggc gaggactgcc    600

tgtggtacct ggaccggaat ggctcctggc atccggggtt taactgcgag ttcttcacct    660

tctgctgcgg gacctgctac catcggtact gctgcaggga cctgaccttg cttatcaccg    720

agaggcagca gaagcactgc ctggccttca gccccaagac catagcaggc atcgcctcag    780

ctgtgatcct ctttgttgct gtggttgcca ccaccatctg ctgcttcctc tgttcctgtt    840

gctacctgta ccgccggcgc cagcagctcc agagcccatt tgaaggccag gagattccaa    900

tgacaggcat cccagtgcag ccagtatacc cataccccca ggaccccaaa gctggccctg    960

cacccccaca accaagccaa gccctgggcc ctactgggga cagagcccca gggaagtgga   1020

acaggagctg aactagaact atgaggggtt ggggggaggg cttggaatta tgggctattt   1080

ttactggggg caagggaggg agatgacagc ctgggtcaca gtgcctgttt tcaaatagtc   1140

cctctgctcc caagatccca gccaggaagg ctggggccct actgtttgtc ccctctgggc   1200

tggggtgggg ggagggagga ggttccgtca gcagctggca gtagccctcc tctctggctg   1260

ccccactggc cacatctctg gcctgctaga ttaaagctgt aaagacataa ctc          1313


<210>  6886
<211>  174
<212>  PRT
<213>  Homosapiens

<400>  6886

Met Pro Pro Ala Gly Leu Arg Arg Ala Ala Pro Leu Thr Ala Ile Ala 
1               5                   10                  15      


Leu Leu Val Leu Gly Ala Pro Leu Val Leu Ala Gly Glu Asp Cys Leu 
            20                  25                  30          


Trp Tyr Leu Asp Arg Asn Gly Ser Trp His Pro Gly Phe Asn Cys Glu 
        35                  40                  45              


Phe Phe Thr Phe Cys Cys Gly Thr Cys Tyr His Arg Tyr Cys Cys Arg 
    50                  55                  60                  


Asp Leu Thr Leu Leu Ile Thr Glu Arg Gln Gln Lys His Cys Leu Ala 
65                  70                  75                  80  


Phe Ser Pro Lys Thr Ile Ala Gly Ile Ala Ser Ala Val Ile Leu Phe 
                85                  90                  95      


Val Ala Val Val Ala Thr Thr Ile Cys Cys Phe Leu Cys Ser Cys Cys 
            100                 105                 110         


Tyr Leu Tyr Arg Arg Arg Gln Gln Leu Gln Ser Pro Phe Glu Gly Gln 
        115                 120                 125             


Glu Ile Pro Met Thr Gly Ile Pro Val Gln Pro Val Tyr Pro Tyr Pro 
    130                 135                 140                 


Gln Asp Pro Lys Ala Gly Pro Ala Pro Pro Gln Pro Ser Gln Ala Leu 
145                 150                 155                 160 


Gly Pro Thr Gly Asp Arg Ala Pro Gly Lys Trp Asn Arg Ser 
                165                 170                 


<210>  6887
<211>  1559
<212>  DNA
<213>  Homosapiens

<400>  6887
gacgcggcag aggaggtccc ccacaagtga aggtccagcc ctgctcctcc agggttggcc     60

catgtgtctg ggcattcgga ggtggcacca ggatcagggc ttctggagtc cagcatagtg    120

attgggccca ggccgggggc gggtccagga cacagccagg cttccctggc cgcagtgccc    180

aactgcccgc agtgcccatg gtggctcgga tgggaggaac caccgcggag ccggggacag    240

ggggagcagg gcagtgctct gctgggtgag gggcacccag ctccagaggc taggtgggcg    300

tcgctggtgg gtggactcct gggcgctgcg cggagccgcg ccggctgggt tagcgcgggc    360

ggggcgctta gtcccacccc cagaggaggc ggaagaggag cccgagcctg gccgcgggct    420

gggccccgcc gcagctccag ctggccggct tggtcctgcg gtcccttctc tgggaggccc    480

gaccccggcc gcgcccagcc cccaccatgc cacccgcggg gctccgccgg gccgcgccgc    540

tcaccgcaat cgctctgttg gtgctggggg ctcccctggt gctggccggc gaggactgcc    600

tgtggtacct ggaccggaat ggctcctggc atccggggtt taactgcgag ttcttcacct    660

tctgctgcgg gacctgctac catcggtact gctgcaggga cctgaccttg cttatcaccg    720

agaggcagca gaagcactgc ctggccttca gccccaagac catagcaggc atcgcctcag    780

ctgtgatcct ctttgttgct gtggttgcca ccaccatctg ctgcttcctc tgttcctgtt    840

gctacctgta ccgccggcgc cagcagctcc agagcccatt tgaaggccag gagattccaa    900

tgacaggcat cccagtgcag ccagtatacc cataccccca ggaccccaaa gctggccctg    960

cacccccaca gcctggcttc atatacccac ctagtggtcc tgctccccaa tatccactct   1020

acccagctgg gcccccagtc tacaaccctg cagctcctcc tccctatatg ccaccacagc   1080

cctcttaccc gggagcctga ggaaccagcc atgtctctgc tgccccttca gtgatgccaa   1140

ccttgggaga tgccctcatc ctgtacctgc atctggtcct gggggtggca ggagtcctcc   1200

agccaccagg ccccagacca agccaagccc tgggccctac tggggacaga gccccaggga   1260

agtggaacag gagctgaact agaactatga ggggttgggg ggagggcttg gaattatggg   1320

ctatttttac tgggggcaag ggagggagat gacagcctgg gtcacagtgc ctgttttcaa   1380

atagtccctc tgctcccaag atcccagcca ggaaggctgg ggccctactg tttgtcccct   1440

ctgggctggg gtggggggag ggaggaggtt ccgtcagcag ctggcagtag ccctcctctc   1500

tggctgcccc actggccaca tctctggcct gctagattaa agctgtaaag acataactc    1559


<210>  6888
<211>  197
<212>  PRT
<213>  Homosapiens

<400>  6888

Met Pro Pro Ala Gly Leu Arg Arg Ala Ala Pro Leu Thr Ala Ile Ala 
1               5                   10                  15      


Leu Leu Val Leu Gly Ala Pro Leu Val Leu Ala Gly Glu Asp Cys Leu 
            20                  25                  30          


Trp Tyr Leu Asp Arg Asn Gly Ser Trp His Pro Gly Phe Asn Cys Glu 
        35                  40                  45              


Phe Phe Thr Phe Cys Cys Gly Thr Cys Tyr His Arg Tyr Cys Cys Arg 
    50                  55                  60                  


Asp Leu Thr Leu Leu Ile Thr Glu Arg Gln Gln Lys His Cys Leu Ala 
65                  70                  75                  80  


Phe Ser Pro Lys Thr Ile Ala Gly Ile Ala Ser Ala Val Ile Leu Phe 
                85                  90                  95      


Val Ala Val Val Ala Thr Thr Ile Cys Cys Phe Leu Cys Ser Cys Cys 
            100                 105                 110         


Tyr Leu Tyr Arg Arg Arg Gln Gln Leu Gln Ser Pro Phe Glu Gly Gln 
        115                 120                 125             


Glu Ile Pro Met Thr Gly Ile Pro Val Gln Pro Val Tyr Pro Tyr Pro 
    130                 135                 140                 


Gln Asp Pro Lys Ala Gly Pro Ala Pro Pro Gln Pro Gly Phe Ile Tyr 
145                 150                 155                 160 


Pro Pro Ser Gly Pro Ala Pro Gln Tyr Pro Leu Tyr Pro Ala Gly Pro 
                165                 170                 175     


Pro Val Tyr Asn Pro Ala Ala Pro Pro Pro Tyr Met Pro Pro Gln Pro 
            180                 185                 190         


Ser Tyr Pro Gly Ala 
        195         


<210>  6889
<211>  1766
<212>  DNA
<213>  Homosapiens

<400>  6889
gacgcggcag aggaggtccc ccacaagtga aggtccagcc ctgctcctcc agggttggcc     60

catgtgtctg ggcattcgga ggtggcacca ggatcagggc ttctggagtc cagcatagtg    120

attgggccca ggccgggggc gggtccagga cacagccagg cttccctggc cgcagtgccc    180

aactgcccgc agtgcccatg gtggctcgga tgggaggaac caccgcggag ccggggacag    240

ggggagcagg gcagtgctct gctgggtgag gggcacccag ctccagaggc taggtgggcg    300

tcgctggtgg gtggactcct gggcgctgcg cggagccgcg ccggctgggt tagcgcgggc    360

ggggcgctta gtcccacccc cagaggaggc ggaagaggag cccgagcctg gccgcgggct    420

gggccccgcc gcagctccag ctggccggct tggtcctgcg gtcccttctc tgggaggccc    480

gaccccggcc gcgcccagcc cccaccatgc cacccgcggg gctccgccgg gccgcgccgc    540

tcaccgcaat cgctctgttg gtgctggggg ctcccctggt gctggccggc gaggactgcc    600

tgtggtacct ggaccggaat ggctcctggc atccggggtt taactgcgag ttcttcacct    660

tctgctgcgg gacctgctac catcggtact gctgcaggga cctgaccttg cttatcaccg    720

agaggcagca gaagcactgc ctggccttca gccccaagac catagcaggc atcgcctcag    780

ctgtgatcct ctttgttgct gtggttgcca ccaccatctg ctgcttcctc tgttcctgtt    840

gctacctgta ccgccggcgc cagcagctcc agagcccatt tgaaggccag gagattccaa    900

tgacaggcat cccagtgcag ccagtatacc cataccccca ggaccccaaa gctggccctg    960

cacccccaca accaagccaa gccctgggcc ctactgggga cagagcccca gggaagtgga   1020

acaggagctg aactagaact atgaggggtt ggggggaggg cttggaatta tgggctattt   1080

ttactggggg caagggaggg agatgacagc ctgggtcaca gtgcctgttt tcaaatagtc   1140

cctctgctcc caagatccca gccaggaagg ctggggccct actgtttgtc ccctctgggc   1200

tggggtgggg ggagggagga ggttccgtca gcagctggca gtagccctcc tctctggctg   1260

ccccactggc cacatctctg gcctgctaga ttaaagctgt aaagacataa ctcatatcag   1320

tcgcatcatt ggacccatcc acaccttcca ggaacaccgc cttcagctgg gcccagactg   1380

ttgcccactc catattccaa aagtagggga gggccagcac cagcatcgga gcacagcacc   1440

atcctcaccc ccatccacaa gcagaccaag gcggactgtt cctggcttcc taaaggcttc   1500

ctaaagacaa tgaggtgaat tttgccacag ctctgaagag atgctcgttt gcactacaga   1560

tattccctgc tagggatcaa cagctctaca acagctgagg cactgctaac tgtacaaagg   1620

cagttcccat tcaggtaccc ttagattcat tctgggcccc accactttct gaccttggcc   1680

atgtctccaa aggttcccaa gcctcaatgt ccttatctat agaatggaga taggacaggt   1740

gcggtagctc atgcctgtaa tctcag                                        1766


<210>  6890
<211>  174
<212>  PRT
<213>  Homosapiens

<400>  6890

Met Pro Pro Ala Gly Leu Arg Arg Ala Ala Pro Leu Thr Ala Ile Ala 
1               5                   10                  15      


Leu Leu Val Leu Gly Ala Pro Leu Val Leu Ala Gly Glu Asp Cys Leu 
            20                  25                  30          


Trp Tyr Leu Asp Arg Asn Gly Ser Trp His Pro Gly Phe Asn Cys Glu 
        35                  40                  45              


Phe Phe Thr Phe Cys Cys Gly Thr Cys Tyr His Arg Tyr Cys Cys Arg 
    50                  55                  60                  


Asp Leu Thr Leu Leu Ile Thr Glu Arg Gln Gln Lys His Cys Leu Ala 
65                  70                  75                  80  


Phe Ser Pro Lys Thr Ile Ala Gly Ile Ala Ser Ala Val Ile Leu Phe 
                85                  90                  95      


Val Ala Val Val Ala Thr Thr Ile Cys Cys Phe Leu Cys Ser Cys Cys 
            100                 105                 110         


Tyr Leu Tyr Arg Arg Arg Gln Gln Leu Gln Ser Pro Phe Glu Gly Gln 
        115                 120                 125             


Glu Ile Pro Met Thr Gly Ile Pro Val Gln Pro Val Tyr Pro Tyr Pro 
    130                 135                 140                 


Gln Asp Pro Lys Ala Gly Pro Ala Pro Pro Gln Pro Ser Gln Ala Leu 
145                 150                 155                 160 


Gly Pro Thr Gly Asp Arg Ala Pro Gly Lys Trp Asn Arg Ser 
                165                 170                 


<210>  6891
<211>  2012
<212>  DNA
<213>  Homosapiens

<400>  6891
gacgcggcag aggaggtccc ccacaagtga aggtccagcc ctgctcctcc agggttggcc     60

catgtgtctg ggcattcgga ggtggcacca ggatcagggc ttctggagtc cagcatagtg    120

attgggccca ggccgggggc gggtccagga cacagccagg cttccctggc cgcagtgccc    180

aactgcccgc agtgcccatg gtggctcgga tgggaggaac caccgcggag ccggggacag    240

ggggagcagg gcagtgctct gctgggtgag gggcacccag ctccagaggc taggtgggcg    300

tcgctggtgg gtggactcct gggcgctgcg cggagccgcg ccggctgggt tagcgcgggc    360

ggggcgctta gtcccacccc cagaggaggc ggaagaggag cccgagcctg gccgcgggct    420

gggccccgcc gcagctccag ctggccggct tggtcctgcg gtcccttctc tgggaggccc    480

gaccccggcc gcgcccagcc cccaccatgc cacccgcggg gctccgccgg gccgcgccgc    540

tcaccgcaat cgctctgttg gtgctggggg ctcccctggt gctggccggc gaggactgcc    600

tgtggtacct ggaccggaat ggctcctggc atccggggtt taactgcgag ttcttcacct    660

tctgctgcgg gacctgctac catcggtact gctgcaggga cctgaccttg cttatcaccg    720

agaggcagca gaagcactgc ctggccttca gccccaagac catagcaggc atcgcctcag    780

ctgtgatcct ctttgttgct gtggttgcca ccaccatctg ctgcttcctc tgttcctgtt    840

gctacctgta ccgccggcgc cagcagctcc agagcccatt tgaaggccag gagattccaa    900

tgacaggcat cccagtgcag ccagtatacc cataccccca ggaccccaaa gctggccctg    960

cacccccaca gcctggcttc atatacccac ctagtggtcc tgctccccaa tatccactct   1020

acccagctgg gcccccagtc tacaaccctg cagctcctcc tccctatatg ccaccacagc   1080

cctcttaccc gggagcctga ggaaccagcc atgtctctgc tgccccttca gtgatgccaa   1140

ccttgggaga tgccctcatc ctgtacctgc atctggtcct gggggtggca ggagtcctcc   1200

agccaccagg ccccagacca agccaagccc tgggccctac tggggacaga gccccaggga   1260

agtggaacag gagctgaact agaactatga ggggttgggg ggagggcttg gaattatggg   1320

ctatttttac tgggggcaag ggagggagat gacagcctgg gtcacagtgc ctgttttcaa   1380

atagtccctc tgctcccaag atcccagcca ggaaggctgg ggccctactg tttgtcccct   1440

ctgggctggg gtggggggag ggaggaggtt ccgtcagcag ctggcagtag ccctcctctc   1500

tggctgcccc actggccaca tctctggcct gctagattaa agctgtaaag acataactca   1560

tatcagtcgc atcattggac ccatccacac cttccaggaa caccgccttc agctgggccc   1620

agactgttgc ccactccata ttccaaaagt aggggagggc cagcaccagc atcggagcac   1680

agcaccatcc tcacccccat ccacaagcag accaaggcgg actgttcctg gcttcctaaa   1740

ggcttcctaa agacaatgag gtgaattttg ccacagctct gaagagatgc tcgtttgcac   1800

tacagatatt ccctgctagg gatcaacagc tctacaacag ctgaggcact gctaactgta   1860

caaaggcagt tcccattcag gtacccttag attcattctg ggccccacca ctttctgacc   1920

ttggccatgt ctccaaaggt tcccaagcct caatgtcctt atctatagaa tggagatagg   1980

acaggtgcgg tagctcatgc ctgtaatctc ag                                 2012


<210>  6892
<211>  197
<212>  PRT
<213>  Homosapiens

<400>  6892

Met Pro Pro Ala Gly Leu Arg Arg Ala Ala Pro Leu Thr Ala Ile Ala 
1               5                   10                  15      


Leu Leu Val Leu Gly Ala Pro Leu Val Leu Ala Gly Glu Asp Cys Leu 
            20                  25                  30          


Trp Tyr Leu Asp Arg Asn Gly Ser Trp His Pro Gly Phe Asn Cys Glu 
        35                  40                  45              


Phe Phe Thr Phe Cys Cys Gly Thr Cys Tyr His Arg Tyr Cys Cys Arg 
    50                  55                  60                  


Asp Leu Thr Leu Leu Ile Thr Glu Arg Gln Gln Lys His Cys Leu Ala 
65                  70                  75                  80  


Phe Ser Pro Lys Thr Ile Ala Gly Ile Ala Ser Ala Val Ile Leu Phe 
                85                  90                  95      


Val Ala Val Val Ala Thr Thr Ile Cys Cys Phe Leu Cys Ser Cys Cys 
            100                 105                 110         


Tyr Leu Tyr Arg Arg Arg Gln Gln Leu Gln Ser Pro Phe Glu Gly Gln 
        115                 120                 125             


Glu Ile Pro Met Thr Gly Ile Pro Val Gln Pro Val Tyr Pro Tyr Pro 
    130                 135                 140                 


Gln Asp Pro Lys Ala Gly Pro Ala Pro Pro Gln Pro Gly Phe Ile Tyr 
145                 150                 155                 160 


Pro Pro Ser Gly Pro Ala Pro Gln Tyr Pro Leu Tyr Pro Ala Gly Pro 
                165                 170                 175     


Pro Val Tyr Asn Pro Ala Ala Pro Pro Pro Tyr Met Pro Pro Gln Pro 
            180                 185                 190         


Ser Tyr Pro Gly Ala 
        195         


<210>  6893
<211>  1077
<212>  DNA
<213>  Homosapiens

<400>  6893
catggtggct cggatgggag gaaccaccgc ggagccgggg acagggggag cagggcagtg     60

ctctgctggg tgaggggcac ccagctccag aggctagtgc tggccggcga ggactgcctg    120

tggtacctgg accggaatgg ctcctggcat ccggggttta actgcgagtt cttcaccttc    180

tgctgcggga cctgctacca tcggtactgc tgcagggacc tgaccttgct tatcaccgag    240

aggcagcaga agcactgcct ggccttcagc cccaagacca tagcaggcat cgcctcagct    300

gtgatcctct ttgttgctgt ggttgccacc accatctgct gcttcctctg ttcctgttgc    360

tacctgtacc gccggcgcca gcagctccag agcccatttg aaggccagga gattccaatg    420

acaggcatcc cagtgcagcc agtataccca tacccccagg accccaaagc tggccctgca    480

cccccacagc ctggcttcat atacccacct agtggtcctg ctccccaata tccactctac    540

ccagctgggc ccccagtcta caaccctgca gctcctcctc cctatatgcc accacagccc    600

tcttacccgg gagcctgagg aaccagccat gtctctgctg ccccttcagt gatgccaacc    660

ttgggagatg ccctcatcct gtacctgcat ctggtcctgg gggtggcagg agtcctccag    720

ccaccaggcc ccagaccaag ccaagccctg ggccctactg gggacagagc cccagggaag    780

tggaacagga gctgaactag aactatgagg ggttgggggg agggcttgga attatgggct    840

atttttactg ggggcaaggg agggagatga cagcctgggt cacagtgcct gttttcaaat    900

agtccctctg ctcccaagat cccagccagg aaggctgggg ccctactgtt tgtcccctct    960

gggctggggt ggggggaggg aggaggttcc gtcagcagct ggcagtagcc ctcctctctg   1020

gctgccccac tggccacatc tctggcctgc tagattaaag ctgtaaagac ataactc      1077


<210>  6894
<211>  66
<212>  PRT
<213>  Homosapiens

<400>  6894

Met Thr Gly Ile Pro Val Gln Pro Val Tyr Pro Tyr Pro Gln Asp Pro 
1               5                   10                  15      


Lys Ala Gly Pro Ala Pro Pro Gln Pro Gly Phe Ile Tyr Pro Pro Ser 
            20                  25                  30          


Gly Pro Ala Pro Gln Tyr Pro Leu Tyr Pro Ala Gly Pro Pro Val Tyr 
        35                  40                  45              


Asn Pro Ala Ala Pro Pro Pro Tyr Met Pro Pro Gln Pro Ser Tyr Pro 
    50                  55                  60                  


Gly Ala 
65      


<210>  6895
<211>  1530
<212>  DNA
<213>  Homosapiens

<400>  6895
catggtggct cggatgggag gaaccaccgc ggagccgggg acagggggag cagggcagtg     60

ctctgctggg tgaggggcac ccagctccag aggctagtgc tggccggcga ggactgcctg    120

tggtacctgg accggaatgg ctcctggcat ccggggttta actgcgagtt cttcaccttc    180

tgctgcggga cctgctacca tcggtactgc tgcagggacc tgaccttgct tatcaccgag    240

aggcagcaga agcactgcct ggccttcagc cccaagacca tagcaggcat cgcctcagct    300

gtgatcctct ttgttgctgt ggttgccacc accatctgct gcttcctctg ttcctgttgc    360

tacctgtacc gccggcgcca gcagctccag agcccatttg aaggccagga gattccaatg    420

acaggcatcc cagtgcagcc agtataccca tacccccagg accccaaagc tggccctgca    480

cccccacagc ctggcttcat atacccacct agtggtcctg ctccccaata tccactctac    540

ccagctgggc ccccagtcta caaccctgca gctcctcctc cctatatgcc accacagccc    600

tcttacccgg gagcctgagg aaccagccat gtctctgctg ccccttcagt gatgccaacc    660

ttgggagatg ccctcatcct gtacctgcat ctggtcctgg gggtggcagg agtcctccag    720

ccaccaggcc ccagaccaag ccaagccctg ggccctactg gggacagagc cccagggaag    780

tggaacagga gctgaactag aactatgagg ggttgggggg agggcttgga attatgggct    840

atttttactg ggggcaaggg agggagatga cagcctgggt cacagtgcct gttttcaaat    900

agtccctctg ctcccaagat cccagccagg aaggctgggg ccctactgtt tgtcccctct    960

gggctggggt ggggggaggg aggaggttcc gtcagcagct ggcagtagcc ctcctctctg   1020

gctgccccac tggccacatc tctggcctgc tagattaaag ctgtaaagac ataactcata   1080

tcagtcgcat cattggaccc atccacacct tccaggaaca ccgccttcag ctgggcccag   1140

actgttgccc actccatatt ccaaaagtag gggagggcca gcaccagcat cggagcacag   1200

caccatcctc acccccatcc acaagcagac caaggcggac tgttcctggc ttcctaaagg   1260

cttcctaaag acaatgaggt gaattttgcc acagctctga agagatgctc gtttgcacta   1320

cagatattcc ctgctaggga tcaacagctc tacaacagct gaggcactgc taactgtaca   1380

aaggcagttc ccattcaggt acccttagat tcattctggg ccccaccact ttctgacctt   1440

ggccatgtct ccaaaggttc ccaagcctca atgtccttat ctatagaatg gagataggac   1500

aggtgcggta gctcatgcct gtaatctcag                                    1530


<210>  6896
<211>  66
<212>  PRT
<213>  Homosapiens

<400>  6896

Met Thr Gly Ile Pro Val Gln Pro Val Tyr Pro Tyr Pro Gln Asp Pro 
1               5                   10                  15      


Lys Ala Gly Pro Ala Pro Pro Gln Pro Gly Phe Ile Tyr Pro Pro Ser 
            20                  25                  30          


Gly Pro Ala Pro Gln Tyr Pro Leu Tyr Pro Ala Gly Pro Pro Val Tyr 
        35                  40                  45              


Asn Pro Ala Ala Pro Pro Pro Tyr Met Pro Pro Gln Pro Ser Tyr Pro 
    50                  55                  60                  


Gly Ala 
65      


<210>  6897
<211>  1487
<212>  DNA
<213>  Homosapiens

<400>  6897
ttggtcctgc ggtcccttct ctgggaggcc cgaccccggc cgcgcccagc ccccaccatg     60

ccacccgcgg ggctccgccg ggccgcgccg ctcaccgcaa tcgctctgtt ggtgctgggg    120

gctcccctgg gtaaggggat ggggagagat gcggcaggag tgggatgggg gcggaggaag    180

gggagggacc gatccgaggg gcttgggctc ggggcttctc cgagaccctc cggctgccac    240

gggagccttg ggtgttgctg ggtcctcaag aagcgggaag agggagctcc aggatgctgg    300

gccatgggag gctgatcccg gggtgcaggg tcagcttcag gcagaggcct cgggggctct    360

ggggctgaga ccctcagggt ggagacaagg ggcaaccctc agtgttcggg agccgtcagg    420

ctggggaccg ccgggggagt ggggccgagc gcggctgggg atgaactggc ctggtggcca    480

ctgggcaccc ccaatccctg cccgcagtgc tggccggcga ggactgcctg tggtacctgg    540

accggaatgg ctcctggcat ccggggttta actgcgagtt cttcaccttc tgctgcggga    600

cctgctacca tcggtactgc tgcagggacc tgaccttgct tatcaccgag aggcagcaga    660

agcactgcct ggccttcagc cccaagacca tagcaggcat cgcctcagct gtgatcctct    720

ttgttgctgt ggttgccacc accatctgct gcttcctctg ttcctgttgc tacctgtacc    780

gccggcgcca gcagctccag agcccatttg aaggccagga gattccaatg acaggcatcc    840

cagtgcagcc agtataccca tacccccagg accccaaagc tggccctgca cccccacagc    900

ctggcttcat atacccacct agtggtcctg ctccccaata tccactctac ccagctgggc    960

ccccagtcta caaccctgca gctcctcctc cctatatgcc accacagccc tcttacccgg   1020

gagcctgagg aaccagccat gtctctgctg ccccttcagt gatgccaacc ttgggagatg   1080

ccctcatcct gtacctgcat ctggtcctgg gggtggcagg agtcctccag ccaccaggcc   1140

ccagaccaag ccaagccctg ggccctactg gggacagagc cccagggaag tggaacagga   1200

gctgaactag aactatgagg ggttgggggg agggcttgga attatgggct atttttactg   1260

ggggcaaggg agggagatga cagcctgggt cacagtgcct gttttcaaat agtccctctg   1320

ctcccaagat cccagccagg aaggctgggg ccctactgtt tgtcccctct gggctggggt   1380

ggggggaggg aggaggttcc gtcagcagct ggcagtagcc ctcctctctg gctgccccac   1440

tggccacatc tctggcctgc tagattaaag ctgtaaagac ataactc                 1487


<210>  6898
<211>  66
<212>  PRT
<213>  Homosapiens

<400>  6898

Met Thr Gly Ile Pro Val Gln Pro Val Tyr Pro Tyr Pro Gln Asp Pro 
1               5                   10                  15      


Lys Ala Gly Pro Ala Pro Pro Gln Pro Gly Phe Ile Tyr Pro Pro Ser 
            20                  25                  30          


Gly Pro Ala Pro Gln Tyr Pro Leu Tyr Pro Ala Gly Pro Pro Val Tyr 
        35                  40                  45              


Asn Pro Ala Ala Pro Pro Pro Tyr Met Pro Pro Gln Pro Ser Tyr Pro 
    50                  55                  60                  


Gly Ala 
65      


<210>  6899
<211>  493
<212>  DNA
<213>  Homosapiens

<400>  6899
tgtctgcccc tggatcagac ccagacaggg aggggctgct gatgctggta gagacagagc     60

tgaggccaca gtcctaccct ctcctccagg ccctacccag ccccgccctg ttggctcatg    120

cccacaacta cttaacttct tgagctgctt gaggttgctg gagcggatgg cagccaatag    180

ctggtcacgg gagttcttct cctgggcagg gaggactttg tctcccatct tcctctgggt    240

agctgatgtg tcgctggttg tggaagcgga gctcggtcag cgtgttgttc tggaggaggg    300

cccggaagat ggccaggatg cctttgcctg tgatgtggtt ggagtccagg ttgaggctgg    360

tgatggtctt gttggccttg agcatgatgg caatggcaaa ggccacgtgg tcatcggctc    420

gcgtgttggc caaggcgaac agcttaacca cagtgttgaa ctccagagcc tcagtaaacc    480

ggaccaagat ctc                                                       493


<210>  6900
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  6900

Met Ala Ala Asn Ser Trp Ser Arg Glu Phe Phe Ser Trp Ala Gly Arg 
1               5                   10                  15      


Thr Leu Ser Pro Ile Phe Leu Trp Val Ala Asp Val Ser Leu Val Val 
            20                  25                  30          


Glu Ala Glu Leu Gly Gln Arg Val Val Leu Glu Glu Gly Pro Glu Asp 
        35                  40                  45              


Gly Gln Asp Ala Phe Ala Cys Asp Val Val Gly Val Gln Val Glu Ala 
    50                  55                  60                  


Gly Asp Gly Leu Val Gly Leu Glu His Asp Gly Asn Gly Lys Gly His 
65                  70                  75                  80  


Val Val Ile Gly Ser Arg Val Gly Gln Gly Glu Gln Leu Asn His Ser 
                85                  90                  95      


Val Glu Leu Gln Ser Leu Ser Lys Pro Asp Gln Asp 
            100                 105             


<210>  6901
<211>  1143
<212>  DNA
<213>  Homosapiens

<400>  6901
ggctgccagg caccatctgc caatgccatg actgctcagg cctcacctcc cagggctaca     60

cagaccctgc ccaccccatc cctggctgac ctgctgtgga tgtccctatt ctgccatggg    120

agagtccagg cctgggtcac gctcaaggaa ggatgcctta tctcttctca ctttcctttt    180

cttgtctctg aggctctcca aattttgctt tagtacatgg agctcaggtt tctggacaag    240

aagagtcctt ttagcacatc actgagaaga tggcactgtc cagggcccat gtagctggca    300

agctgcaaaa ggcctgtgat ccaggaaaga tgtcccacag ggaccacatc caccccagcc    360

ccactgccct ccagggccag gattcaggcc tctgaggagc ccacggggca aagctgctgg    420

gccagtggca ctctgtgtgg gaaaatggca gaaagatgga gaggcatggg ggcccaaagg    480

ggagcgtggg gaggggctga ggatacccca aagtccaggc taattagagg atgtggcagg    540

ggcagtggcc tggatgcaca gtgcctgatg ggagtaggct ccagacagga ggagtgggac    600

agacagcagc tggacttgaa ggtttgatgc caaagcagac attttccctc cacccacttg    660

cctgtcaccc cagtcaccta agcaatcact gggcccagag gagaggagac agacacacac    720

tggctcctgg acctaaaggg tatgagctgg agctaaggcc agctagagct tccactgtca    780

gccctcactg tcagtcccac tgcacccccc tgtgcctgct gggcactggg cactagctag    840

atgctttagg ttgcttcagc tgatccttca actctgtgag gtggatacca atattctatt    900

ttgcagatag aatttggccc agagaggtta actaatatat ccatgatcac acagctaata    960

aaagtcagag ctcaggtctg ttttgtttgt tggttttgtt ttgagcccag gtcttcaggc   1020

catagaactg cttctcatta acagctcccc ttccttccct cactgaaata aggctgtgac   1080

ggtgctgcag gaaagcactg gacgctcacc tgaacccaaa caacctgcct ccaaatctta   1140

agg                                                                 1143


<210>  6902
<211>  101
<212>  PRT
<213>  Homosapiens

<400>  6902

Met Trp Gln Gly Gln Trp Pro Gly Cys Thr Val Pro Asp Gly Ser Arg 
1               5                   10                  15      


Leu Gln Thr Gly Gly Val Gly Gln Thr Ala Ala Gly Leu Glu Gly Leu 
            20                  25                  30          


Met Pro Lys Gln Thr Phe Ser Leu His Pro Leu Ala Cys His Pro Ser 
        35                  40                  45              


His Leu Ser Asn His Trp Ala Gln Arg Arg Gly Asp Arg His Thr Leu 
    50                  55                  60                  


Ala Pro Gly Pro Lys Gly Tyr Glu Leu Glu Leu Arg Pro Ala Arg Ala 
65                  70                  75                  80  


Ser Thr Val Ser Pro His Cys Gln Ser His Cys Thr Pro Leu Cys Leu 
                85                  90                  95      


Leu Gly Thr Gly His 
            100     


<210>  6903
<211>  2207
<212>  DNA
<213>  Homosapiens

<400>  6903
aagatgggag acaaagtcct ccctgcccag gagaagaact cccgtgacca gctattggct     60

gccatccgct ccagcaacct caagcagctc aagaagtgga agtgcccaaa ctgcttcagt    120

aggaccaggc tgccaggcac catctgccaa tgccatgact gctcaggcct cacctcccag    180

ggctacacag accctgccca ccccatccct ggctgacctg ctgtggatgt ccctattctg    240

ccatgggaga gtccaggcct gggtcacgct caaggaagga tgccttatct cttctcactt    300

tccttttctt gtctctgagg ctctccaaat tttgctttag tacatggagc tcaggtttct    360

ggacaagaag agtcctttta gcacatcact gagaagatgg cactgtccag ggcccatgta    420

gctggcaagc tgcaaaaggc ctgtgatcca ggaaagatgt cccacaggga ccacatccac    480

cccagcccca ctgccctcca gggccaggat tcaggcctct gaggagccca cggggcaaag    540

ctgctgggcc agtggcactc tgtgtgggaa aatggcagaa agatggagag gcatgggggc    600

ccaaagggga gcgtggggag gggctgagga taccccaaag tccaggctaa ttagaggatg    660

tggcaggggc agtggcctgg atgcacagtg cctgatggga gtaggctcca gacaggagga    720

gtgggacaga cagcagctgg acttgaaggt ttgatgccaa agcagacatt ttcctcacac    780

ccacctgctg ctgtatgaat agctgtgtat ctgtttttcc ataagatttt gataatatat    840

acaaaccttt agctgtgaat ggctgtgccc cacctgttgt cctgaactgt gagtcctgat    900

cctaaccctg ggctccctgg aggactctag aagctcaggt tccctgccac actatttgag    960

ttggccaaga aataaattca catcctcaga aagtgcagca tggaggaaaa tctgaactct   1020

aagcagaaga ctctccactg acctggttgt ccaggtctag aaggccaggc ctctactagg   1080

tctgctcctg aaccagtcct gctgcctgga gtcagtagcc agagttgttc tcaggggtgc   1140

tggggcagag tggagcccag ggtgctggga tggctatatt aggcatgttc agggatgctc   1200

attccatgac tctgcctaac catgggctca gggccaggtc ctcacagcag tcacaggccc   1260

aggaaggcgg caggcagaga agtggagtga ctatttggag aatagcaccc atatctgtgt   1320

gccctagggc tcagaggggc ctcatcttcc ccagccctcc ccacctgctc accaattcca   1380

cttcctgccc caactgcagg aatgctgaca atgctgccat gcccaccatc gggtgtaggt   1440

gaaaggcatc tttctgaatt tcattctctt gaaggtgctg ccaccccttg gcactgtgga   1500

actgccacct tgggtctgtg tcacttgtag gtttctctgc ctccaggttg cctcaacagc   1560

aggaggcaca gcagtttcac catctttgag gtgagggtgg ggtgccccag ctaggaagca   1620

agatcgctgt gctaggtctg accaaaacca gagggcagtc tagtcctggg ggtaaagccc   1680

tcagatccca gggtacactc ttctccattc cctccaccca cttgcctgtc accccagtca   1740

cctaagcaat cactgggccc agaggagagg agacagacac acactggctc ctggacctaa   1800

agggtatgag ctggagctaa ggccagctag agcttccact gtcagccctc actgtcagtc   1860

ccactgcacc cccctgtgcc tgctgggcac tgggcactag ctagatgctt taggttgctt   1920

cagctgatcc ttcaactctg tgaggtggat accaatattc tattttgcag atagaatttg   1980

gcccagagag gttaactaat atatccatga tcacacagct aataaaagtc agagctcagg   2040

tctgttttgt ttgttggttt tgttttgagc ccaggtcttc aggccataga actgcttctc   2100

attaacagct ccccttcctt ccctcactga aataaggctg tgacggtgct gcaggaaagc   2160

actggacgct cacctgaacc caaacaacct gcctccaaat cttaagg                 2207


<210>  6904
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  6904

Met Gly Asp Lys Val Leu Pro Ala Gln Glu Lys Asn Ser Arg Asp Gln 
1               5                   10                  15      


Leu Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln Leu Lys Lys Trp 
            20                  25                  30          


Lys Cys Pro Asn Cys Phe Ser Arg Thr Arg Leu Pro Gly Thr Ile Cys 
        35                  40                  45              


Gln Cys His Asp Cys Ser Gly Leu Thr Ser Gln Gly Tyr Thr Asp Pro 
    50                  55                  60                  


Ala His Pro Ile Pro Gly 
65                  70  


<210>  6905
<211>  1388
<212>  DNA
<213>  Homosapiens

<400>  6905
agggcagtgg ccaccaagaa ggaagaggag aagaaaggga gtgacaggaa cacaggcttg     60

agcagggaca aggataaaaa gagagaggag atgaaggagg tggccaagaa agaggatgat    120

gagaaggtaa aaggggagcg taggaacaca gacaccagaa aagagggtga gaagatgaaa    180

agagcaggtg ggaacacaga catgaaaaag gaggatgaga aggtaaaaag aggaactggg    240

aacacagaca ccaaaaagga cgatgaaaaa gtcaagaaga atgaaccctt acatgaaaag    300

gaagccaagg atgacagcaa gaccaaaaca cccgagaaac agacgcccag tggccccacc    360

aagccctctg aaggaccggc caaggtggag gaggaggcag ctcccagcat atttgatgag    420

cctctggaga gagtgaagaa caatgacccc gagatgactg aggtgaacgt caacaactca    480

gactgcatca caaatgagat cttggtccgg tttactgagg ctctggagtt caacactgtg    540

gttaagctgt tcgccttggc caacacgcga gccgatgacc acgtggcctt tgccattgcc    600

atcatgctca aggccaacaa gaccatcacc agcctcaacc tggactccaa ccacatcaca    660

ggcaaaggca tcctggccat cttccgggcc ctcctccaga acaacacgct gaccgagctc    720

cgcttccaca accagcgaca catctgtgga ggcaagacgg agatggagat cgccaagctg    780

ctgaaggaga atactaccct gctcaagctg ggctaccatt ttgagctggc cgggccccga    840

atgactgtca ccaatctgct cagccgcaac atggacaagc agagacaaaa gcggctgcag    900

gagcaaaggc aggcccagtc acctaagcaa tcactgggcc cagaggagag gagacagaca    960

cacactggct cctggaccta aagggtatga gctggagcta aggccagcta gagcttccac   1020

tgtcagccct cactgtcagt cccactgcac ccccctgtgc ctgctgggca ctgggcacta   1080

gctagatgct ttaggttgct tcagctgatc cttcaactct gtgaggtgga taccaatatt   1140

ctattttgca gatagaattt ggcccagaga ggttaactaa tatatccatg atcacacagc   1200

taataaaagt cagagctcag gtctgttttg tttgttggtt ttgttttgag cccaggtctt   1260

caggccatag aactgcttct cattaacagc tccccttcct tccctcactg aaataaggct   1320

gtgacggtgc tgcaggaaag cactggacgc tcacctgaac ccaaacaacc tgcctccaaa   1380

tcttaagg                                                            1388


<210>  6906
<211>  296
<212>  PRT
<213>  Homosapiens

<400>  6906

Met Lys Glu Val Ala Lys Lys Glu Asp Asp Glu Lys Val Lys Gly Glu 
1               5                   10                  15      


Arg Arg Asn Thr Asp Thr Arg Lys Glu Gly Glu Lys Met Lys Arg Ala 
            20                  25                  30          


Gly Gly Asn Thr Asp Met Lys Lys Glu Asp Glu Lys Val Lys Arg Gly 
        35                  40                  45              


Thr Gly Asn Thr Asp Thr Lys Lys Asp Asp Glu Lys Val Lys Lys Asn 
    50                  55                  60                  


Glu Pro Leu His Glu Lys Glu Ala Lys Asp Asp Ser Lys Thr Lys Thr 
65                  70                  75                  80  


Pro Glu Lys Gln Thr Pro Ser Gly Pro Thr Lys Pro Ser Glu Gly Pro 
                85                  90                  95      


Ala Lys Val Glu Glu Glu Ala Ala Pro Ser Ile Phe Asp Glu Pro Leu 
            100                 105                 110         


Glu Arg Val Lys Asn Asn Asp Pro Glu Met Thr Glu Val Asn Val Asn 
        115                 120                 125             


Asn Ser Asp Cys Ile Thr Asn Glu Ile Leu Val Arg Phe Thr Glu Ala 
    130                 135                 140                 


Leu Glu Phe Asn Thr Val Val Lys Leu Phe Ala Leu Ala Asn Thr Arg 
145                 150                 155                 160 


Ala Asp Asp His Val Ala Phe Ala Ile Ala Ile Met Leu Lys Ala Asn 
                165                 170                 175     


Lys Thr Ile Thr Ser Leu Asn Leu Asp Ser Asn His Ile Thr Gly Lys 
            180                 185                 190         


Gly Ile Leu Ala Ile Phe Arg Ala Leu Leu Gln Asn Asn Thr Leu Thr 
        195                 200                 205             


Glu Leu Arg Phe His Asn Gln Arg His Ile Cys Gly Gly Lys Thr Glu 
    210                 215                 220                 


Met Glu Ile Ala Lys Leu Leu Lys Glu Asn Thr Thr Leu Leu Lys Leu 
225                 230                 235                 240 


Gly Tyr His Phe Glu Leu Ala Gly Pro Arg Met Thr Val Thr Asn Leu 
                245                 250                 255     


Leu Ser Arg Asn Met Asp Lys Gln Arg Gln Lys Arg Leu Gln Glu Gln 
            260                 265                 270         


Arg Gln Ala Gln Ser Pro Lys Gln Ser Leu Gly Pro Glu Glu Arg Arg 
        275                 280                 285             


Gln Thr His Thr Gly Ser Trp Thr 
    290                 295     


<210>  6907
<211>  3719
<212>  DNA
<213>  Homosapiens

<400>  6907
cagcacctgt agcacagaag ggccaaggag ctgcagtcct cgaccagcag gaggtttgct     60

cctcagccca ctcgctgcat ccagatcagc tcacccctct cccttccctg cccaccagga    120

ctctgatagc ccctggcagc cacagcccat tttgccaaga tgtctagagt agccaaatat    180

cgccggcagg tgagtgaaga ccccgacatc gacagcctgc tggagaccct gtctcccgag    240

gagatggagg agctggagaa ggagctggac gtggtggacc cagacgggag tgttcccgtg    300

gggctgcggc agagaaacca gacggagaaa cagtccacgg gtgtgtacaa ccgggaggcc    360

atgctcaact tctgtgaaaa ggagaccaag aaggaagagg agaagaaagg gagtgacagg    420

aacacaggct tgagcaggga caaggataaa aagagagagg agatgaagga ggtggccaag    480

aaagaggatg atgagaaggt aaaaggggag cgtaggaaca cagacaccag aaaagagggt    540

gagaagatga aaagagcagg tgggaacaca gacatgaaaa aggaggatga gaaggtaaaa    600

agaggaactg ggaacacaga caccaaaaag gacgatgaaa aagtcaagaa gaatgaaccc    660

ttacatgaaa aggaagccaa ggatgacagc aagaccaaaa cacccgagaa acagacgccc    720

agtggcccca ccaagccctc tgaaggaccg gccaaggtgg aggaggaggc agctcccagc    780

atatttgatg agcctctgga gagagtgaag aacaatgacc ccgagatgac tgaggtgaac    840

gtcaacaact cagactgcat cacaaatgag atcttggtcc ggtttactga ggctctggag    900

ttcaacactg tggttaagct gttcgccttg gccaacacgc gagccgatga ccacgtggcc    960

tttgccattg ccatcatgct caaggccaac aagaccatca ccagcctcaa cctggactcc   1020

aaccacatca caggcaaagg catcctggcc atcttccggg ccctcctcca gaacaacacg   1080

ctgaccgagc tccgcttcca caaccagcga cacatctgtg gaggcaagac ggagatggag   1140

atcgccaagc tgctgaagga gaatactacc ctgctcaagc tgggctacca ttttgagctg   1200

gccgggcccc gaatgactgt caccaatctg ctcagccgca acatggacaa gcagagacaa   1260

aagcggctgc aggagcaaag gcaggcacag gaagccaagg gagagaagaa ggatctgctg   1320

gaggtaccca aggccggggc cgtggctaag ggctccccaa aaccttcacc tcaaccatct   1380

ccaaagccct ctccaaagaa ctcacccaaa aaagggggtg ctccagctgc cccaccaccc   1440

cctccccctc ccttggctcc accccttatc atggagaacc tgaagaattc actctcacca   1500

gctacccaga ggaagatggg agacaaagtc ctccctgccc aggagaagaa ctcccgtgac   1560

cagctattgg ctgccatccg ctccagcaac ctcaagcagc tcaagaagtg gaagtgccca   1620

aactgcttca gtaggaccag gctgccaggc accatctgcc aatgccatga ctgctcaggc   1680

ctcacctccc agggctacac agaccctgcc caccccatcc ctggctgacc tgctgtggat   1740

gtccctattc tgccatggga gagtccaggc ctgggtcacg ctcaaggaag gatgccttat   1800

ctcttctcac tttccttttc ttgtctctga ggctctccaa attttgcttt agtacatgga   1860

gctcaggttt ctggacaaga agagtccttt tagcacatca ctgagaagat ggcactgtcc   1920

agggcccatg tagctggcaa gctgcaaaag gcctgtgatc caggaaagat gtcccacagg   1980

gaccacatcc accccagccc cactgccctc cagggccagg attcaggcct ctgaggagcc   2040

cacggggcaa agctgctggg ccagtggcac tctgtgtggg aaaatggcag aaagatggag   2100

aggcatgggg gcccaaaggg gagcgtgggg aggggctgag gataccccaa agtccaggct   2160

aattagagga tgtggcaggg gcagtggcct ggatgcacag tgcctgatgg gagtaggctc   2220

cagacaggag gagtgggaca gacagcagct ggacttgaag gtttgatgcc aaagcagaca   2280

ttttcctcac acccacctgc tgctgtatga atagctgtgt atctgttttt ccataagatt   2340

ttgataatat atacaaacct ttagctgtga atggctgtgc cccacctgtt gtcctgaact   2400

gtgagtcctg atcctaaccc tgggctccct ggaggactct agaagctcag gttccctgcc   2460

acactatttg agttggccaa gaaataaatt cacatcctca gaaagtgcag catggaggaa   2520

aatctgaact ctaagcagaa gactctccac tgacctggtt gtccaggtct agaaggccag   2580

gcctctacta ggtctgctcc tgaaccagtc ctgctgcctg gagtcagtag ccagagttgt   2640

tctcaggggt gctggggcag agtggagccc agggtgctgg gatggctata ttaggcatgt   2700

tcagggatgc tcattccatg actctgccta accatgggct cagggccagg tcctcacagc   2760

agtcacaggc ccaggaaggc ggcaggcaga gaagtggagt gactatttgg agaatagcac   2820

ccatatctgt gtgccctagg gctcagaggg gcctcatctt ccccagccct ccccacctgc   2880

tcaccaattc cacttcctgc cccaactgca ggaatgctga caatgctgcc atgcccacca   2940

tcgggtgtag gtgaaaggca tctttctgaa tttcattctc ttgaaggtgc tgccacccct   3000

tggcactgtg gaactgccac cttgggtctg tgtcacttgt aggtttctct gcctccaggt   3060

tgcctcaaca gcaggaggca cagcagtttc accatctttg aggtgagggt ggggtgcccc   3120

agctaggaag caagatcgct gtgctaggtc tgaccaaaac cagagggcag tctagtcctg   3180

ggggtaaagc cctcagatcc cagggtacac tcttctccat tccctccacc cacttgcctg   3240

tcaccccagt cacctaagca atcactgggc ccagaggaga ggagacagac acacactggc   3300

tcctggacct aaagggtatg agctggagct aaggccagct agagcttcca ctgtcagccc   3360

tcactgtcag tcccactgca cccccctgtg cctgctgggc actgggcact agctagatgc   3420

tttaggttgc ttcagctgat ccttcaactc tgtgaggtgg ataccaatat tctattttgc   3480

agatagaatt tggcccagag aggttaacta atatatccat gatcacacag ctaataaaag   3540

tcagagctca ggtctgtttt gtttgttggt tttgttttga gcccaggtct tcaggccata   3600

gaactgcttc tcattaacag ctccccttcc ttccctcact gaaataaggc tgtgacggtg   3660

ctgcaggaaa gcactggacg ctcacctgaa cccaaacaac ctgcctccaa atcttaagg    3719


<210>  6908
<211>  522
<212>  PRT
<213>  Homosapiens

<400>  6908

Met Ser Arg Val Ala Lys Tyr Arg Arg Gln Val Ser Glu Asp Pro Asp 
1               5                   10                  15      


Ile Asp Ser Leu Leu Glu Thr Leu Ser Pro Glu Glu Met Glu Glu Leu 
            20                  25                  30          


Glu Lys Glu Leu Asp Val Val Asp Pro Asp Gly Ser Val Pro Val Gly 
        35                  40                  45              


Leu Arg Gln Arg Asn Gln Thr Glu Lys Gln Ser Thr Gly Val Tyr Asn 
    50                  55                  60                  


Arg Glu Ala Met Leu Asn Phe Cys Glu Lys Glu Thr Lys Lys Glu Glu 
65                  70                  75                  80  


Glu Lys Lys Gly Ser Asp Arg Asn Thr Gly Leu Ser Arg Asp Lys Asp 
                85                  90                  95      


Lys Lys Arg Glu Glu Met Lys Glu Val Ala Lys Lys Glu Asp Asp Glu 
            100                 105                 110         


Lys Val Lys Gly Glu Arg Arg Asn Thr Asp Thr Arg Lys Glu Gly Glu 
        115                 120                 125             


Lys Met Lys Arg Ala Gly Gly Asn Thr Asp Met Lys Lys Glu Asp Glu 
    130                 135                 140                 


Lys Val Lys Arg Gly Thr Gly Asn Thr Asp Thr Lys Lys Asp Asp Glu 
145                 150                 155                 160 


Lys Val Lys Lys Asn Glu Pro Leu His Glu Lys Glu Ala Lys Asp Asp 
                165                 170                 175     


Ser Lys Thr Lys Thr Pro Glu Lys Gln Thr Pro Ser Gly Pro Thr Lys 
            180                 185                 190         


Pro Ser Glu Gly Pro Ala Lys Val Glu Glu Glu Ala Ala Pro Ser Ile 
        195                 200                 205             


Phe Asp Glu Pro Leu Glu Arg Val Lys Asn Asn Asp Pro Glu Met Thr 
    210                 215                 220                 


Glu Val Asn Val Asn Asn Ser Asp Cys Ile Thr Asn Glu Ile Leu Val 
225                 230                 235                 240 


Arg Phe Thr Glu Ala Leu Glu Phe Asn Thr Val Val Lys Leu Phe Ala 
                245                 250                 255     


Leu Ala Asn Thr Arg Ala Asp Asp His Val Ala Phe Ala Ile Ala Ile 
            260                 265                 270         


Met Leu Lys Ala Asn Lys Thr Ile Thr Ser Leu Asn Leu Asp Ser Asn 
        275                 280                 285             


His Ile Thr Gly Lys Gly Ile Leu Ala Ile Phe Arg Ala Leu Leu Gln 
    290                 295                 300                 


Asn Asn Thr Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Ile Cys 
305                 310                 315                 320 


Gly Gly Lys Thr Glu Met Glu Ile Ala Lys Leu Leu Lys Glu Asn Thr 
                325                 330                 335     


Thr Leu Leu Lys Leu Gly Tyr His Phe Glu Leu Ala Gly Pro Arg Met 
            340                 345                 350         


Thr Val Thr Asn Leu Leu Ser Arg Asn Met Asp Lys Gln Arg Gln Lys 
        355                 360                 365             


Arg Leu Gln Glu Gln Arg Gln Ala Gln Glu Ala Lys Gly Glu Lys Lys 
    370                 375                 380                 


Asp Leu Leu Glu Val Pro Lys Ala Gly Ala Val Ala Lys Gly Ser Pro 
385                 390                 395                 400 


Lys Pro Ser Pro Gln Pro Ser Pro Lys Pro Ser Pro Lys Asn Ser Pro 
                405                 410                 415     


Lys Lys Gly Gly Ala Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Leu 
            420                 425                 430         


Ala Pro Pro Leu Ile Met Glu Asn Leu Lys Asn Ser Leu Ser Pro Ala 
        435                 440                 445             


Thr Gln Arg Lys Met Gly Asp Lys Val Leu Pro Ala Gln Glu Lys Asn 
    450                 455                 460                 


Ser Arg Asp Gln Leu Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln 
465                 470                 475                 480 


Leu Lys Lys Trp Lys Cys Pro Asn Cys Phe Ser Arg Thr Arg Leu Pro 
                485                 490                 495     


Gly Thr Ile Cys Gln Cys His Asp Cys Ser Gly Leu Thr Ser Gln Gly 
            500                 505                 510         


Tyr Thr Asp Pro Ala His Pro Ile Pro Gly 
        515                 520         


<210>  6909
<211>  2042
<212>  DNA
<213>  Homosapiens

<400>  6909
aagatgggag acaaagtcct ccctgcccag gagaagaact cccgtgacca gctattggct     60

gccatccgct ccagcaacct caagcagctc aagaagtgga agtgcccaaa ctgcttcagt    120

aggaccaggc tgccaggcac catctgccaa tgccatgact gctcaggcct cacctcccag    180

ggctacacag accctgccca ccccatccct ggctgacctg ctgtggatgt ccctattctg    240

ccatgggaga gtccaggcct gggtcacgct caaggaagga tgccttatct cttctcactt    300

tccttttctt gtctctgagg ctctccaaat tttgctttag tacatggagc tcaggtttct    360

ggacaagaag agtcctttta gcacatcact gagaagatgg cactgtccag ggcccatgta    420

gctggcaagc tgcaaaaggc ctgtgatcca ggaaagatgt cccacaggga ccacatccac    480

cccagcccca ctgccctcca gggccaggat tcaggcctct gaggagccca cggggcaaag    540

ctgctgggcc agtggcactc tgtgtgggaa aatggcagaa agatggagag gcatgggggc    600

ccaaagggga gcgtggggag gggctgagga taccccaaag tccaggctaa ttagaggatg    660

tggcaggggc agtggcctgg atgcacagtg cctgatggga gtaggctcca gacaggagga    720

gtgggacaga cagcagctgg acttgaaggt ttgatgccaa agcagacatt ttcctcacac    780

ccacctgctg ctgtatgaat agctgtgtat ctgtttttcc ataagatttt gataatatat    840

acaaaccttt agctgtgaat ggctgtgccc cacctgttgt cctgaactgt gagtcctgat    900

cctaaccctg ggctccctgg aggactctag aagctcaggt tccctgccac actatttgag    960

ttggccaaga aataaattca catcctcaga aagtgcagca tggaggaaaa tctgaactct   1020

aagcagaaga ctctccactg acctggttgt ccaggtctag aaggccaggc ctctactagg   1080

tctgctcctg aaccagtcct gctgcctgga gtcagtagcc agagttgttc tcaggggtgc   1140

tggggcagag tggagcccag ggtgctggga tggctatatt aggcatgttc agggatgctc   1200

attccatgac tctgcctaac catgggctca gggccaggtc ctcacagcag tcacaggccc   1260

aggaaggcgg caggcagaga agtggagtga ctatttggag aatagcaccc atatctgtgt   1320

gccctagggc tcagaggggc ctcatcttcc ccagccctcc ccacctgctc accaattcca   1380

cttcctgccc caactgcagg aatgctgaca atgctgccat gcccaccatc gggtgtaggt   1440

gaaaggcatc tttctgaatt tcattctctt gaaggtgctg ccaccccttg gcactgtgga   1500

actgccacct tgggtctgtg tcacttgtag gtttctctgc ctccaggttg cctcaacagc   1560

aggaggcaca gcagtttcac catctttgag gtgagggtgg ggtgccccag ctaggaagca   1620

agatcgctgt gctaggtctg accaaaacca gagggcagtc tagtcctggg ggtaaagccc   1680

tcagatccca gggtacactc ttctccattc cctccaccca cttgcctgtc accccagtca   1740

cctaagcaat cactgggccc agaggagagg agacagacac acactggctc ctggacctaa   1800

agggtatgag ctggagctaa ggccagctag agcttccact gtcagccctc actgtcagtc   1860

ccactgcacc cccctgtgcc tgctgggcac tgggcactag ctagatgctt taggttgctt   1920

cagctgatcc ttcaactctg tgaggtggat accaatattc tattttgcag atagaatttg   1980

gcccagagag gttaactaat atatccatga tcacacagct aataaaagtc agagctcagg   2040

tc                                                                  2042


<210>  6910
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  6910

Met Gly Asp Lys Val Leu Pro Ala Gln Glu Lys Asn Ser Arg Asp Gln 
1               5                   10                  15      


Leu Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln Leu Lys Lys Trp 
            20                  25                  30          


Lys Cys Pro Asn Cys Phe Ser Arg Thr Arg Leu Pro Gly Thr Ile Cys 
        35                  40                  45              


Gln Cys His Asp Cys Ser Gly Leu Thr Ser Gln Gly Tyr Thr Asp Pro 
    50                  55                  60                  


Ala His Pro Ile Pro Gly 
65                  70  


<210>  6911
<211>  3554
<212>  DNA
<213>  Homosapiens

<400>  6911
cagcacctgt agcacagaag ggccaaggag ctgcagtcct cgaccagcag gaggtttgct     60

cctcagccca ctcgctgcat ccagatcagc tcacccctct cccttccctg cccaccagga    120

ctctgatagc ccctggcagc cacagcccat tttgccaaga tgtctagagt agccaaatat    180

cgccggcagg tgagtgaaga ccccgacatc gacagcctgc tggagaccct gtctcccgag    240

gagatggagg agctggagaa ggagctggac gtggtggacc cagacgggag tgttcccgtg    300

gggctgcggc agagaaacca gacggagaaa cagtccacgg gtgtgtacaa ccgggaggcc    360

atgctcaact tctgtgaaaa ggagaccaag aaggaagagg agaagaaagg gagtgacagg    420

aacacaggct tgagcaggga caaggataaa aagagagagg agatgaagga ggtggccaag    480

aaagaggatg atgagaaggt aaaaggggag cgtaggaaca cagacaccag aaaagagggt    540

gagaagatga aaagagcagg tgggaacaca gacatgaaaa aggaggatga gaaggtaaaa    600

agaggaactg ggaacacaga caccaaaaag gacgatgaaa aagtcaagaa gaatgaaccc    660

ttacatgaaa aggaagccaa ggatgacagc aagaccaaaa cacccgagaa acagacgccc    720

agtggcccca ccaagccctc tgaaggaccg gccaaggtgg aggaggaggc agctcccagc    780

atatttgatg agcctctgga gagagtgaag aacaatgacc ccgagatgac tgaggtgaac    840

gtcaacaact cagactgcat cacaaatgag atcttggtcc ggtttactga ggctctggag    900

ttcaacactg tggttaagct gttcgccttg gccaacacgc gagccgatga ccacgtggcc    960

tttgccattg ccatcatgct caaggccaac aagaccatca ccagcctcaa cctggactcc   1020

aaccacatca caggcaaagg catcctggcc atcttccggg ccctcctcca gaacaacacg   1080

ctgaccgagc tccgcttcca caaccagcga cacatctgtg gaggcaagac ggagatggag   1140

atcgccaagc tgctgaagga gaatactacc ctgctcaagc tgggctacca ttttgagctg   1200

gccgggcccc gaatgactgt caccaatctg ctcagccgca acatggacaa gcagagacaa   1260

aagcggctgc aggagcaaag gcaggcacag gaagccaagg gagagaagaa ggatctgctg   1320

gaggtaccca aggccggggc cgtggctaag ggctccccaa aaccttcacc tcaaccatct   1380

ccaaagccct ctccaaagaa ctcacccaaa aaagggggtg ctccagctgc cccaccaccc   1440

cctccccctc ccttggctcc accccttatc atggagaacc tgaagaattc actctcacca   1500

gctacccaga ggaagatggg agacaaagtc ctccctgccc aggagaagaa ctcccgtgac   1560

cagctattgg ctgccatccg ctccagcaac ctcaagcagc tcaagaagtg gaagtgccca   1620

aactgcttca gtaggaccag gctgccaggc accatctgcc aatgccatga ctgctcaggc   1680

ctcacctccc agggctacac agaccctgcc caccccatcc ctggctgacc tgctgtggat   1740

gtccctattc tgccatggga gagtccaggc ctgggtcacg ctcaaggaag gatgccttat   1800

ctcttctcac tttccttttc ttgtctctga ggctctccaa attttgcttt agtacatgga   1860

gctcaggttt ctggacaaga agagtccttt tagcacatca ctgagaagat ggcactgtcc   1920

agggcccatg tagctggcaa gctgcaaaag gcctgtgatc caggaaagat gtcccacagg   1980

gaccacatcc accccagccc cactgccctc cagggccagg attcaggcct ctgaggagcc   2040

cacggggcaa agctgctggg ccagtggcac tctgtgtggg aaaatggcag aaagatggag   2100

aggcatgggg gcccaaaggg gagcgtgggg aggggctgag gataccccaa agtccaggct   2160

aattagagga tgtggcaggg gcagtggcct ggatgcacag tgcctgatgg gagtaggctc   2220

cagacaggag gagtgggaca gacagcagct ggacttgaag gtttgatgcc aaagcagaca   2280

ttttcctcac acccacctgc tgctgtatga atagctgtgt atctgttttt ccataagatt   2340

ttgataatat atacaaacct ttagctgtga atggctgtgc cccacctgtt gtcctgaact   2400

gtgagtcctg atcctaaccc tgggctccct ggaggactct agaagctcag gttccctgcc   2460

acactatttg agttggccaa gaaataaatt cacatcctca gaaagtgcag catggaggaa   2520

aatctgaact ctaagcagaa gactctccac tgacctggtt gtccaggtct agaaggccag   2580

gcctctacta ggtctgctcc tgaaccagtc ctgctgcctg gagtcagtag ccagagttgt   2640

tctcaggggt gctggggcag agtggagccc agggtgctgg gatggctata ttaggcatgt   2700

tcagggatgc tcattccatg actctgccta accatgggct cagggccagg tcctcacagc   2760

agtcacaggc ccaggaaggc ggcaggcaga gaagtggagt gactatttgg agaatagcac   2820

ccatatctgt gtgccctagg gctcagaggg gcctcatctt ccccagccct ccccacctgc   2880

tcaccaattc cacttcctgc cccaactgca ggaatgctga caatgctgcc atgcccacca   2940

tcgggtgtag gtgaaaggca tctttctgaa tttcattctc ttgaaggtgc tgccacccct   3000

tggcactgtg gaactgccac cttgggtctg tgtcacttgt aggtttctct gcctccaggt   3060

tgcctcaaca gcaggaggca cagcagtttc accatctttg aggtgagggt ggggtgcccc   3120

agctaggaag caagatcgct gtgctaggtc tgaccaaaac cagagggcag tctagtcctg   3180

ggggtaaagc cctcagatcc cagggtacac tcttctccat tccctccacc cacttgcctg   3240

tcaccccagt cacctaagca atcactgggc ccagaggaga ggagacagac acacactggc   3300

tcctggacct aaagggtatg agctggagct aaggccagct agagcttcca ctgtcagccc   3360

tcactgtcag tcccactgca cccccctgtg cctgctgggc actgggcact agctagatgc   3420

tttaggttgc ttcagctgat ccttcaactc tgtgaggtgg ataccaatat tctattttgc   3480

agatagaatt tggcccagag aggttaacta atatatccat gatcacacag ctaataaaag   3540

tcagagctca ggtc                                                     3554


<210>  6912
<211>  522
<212>  PRT
<213>  Homosapiens

<400>  6912

Met Ser Arg Val Ala Lys Tyr Arg Arg Gln Val Ser Glu Asp Pro Asp 
1               5                   10                  15      


Ile Asp Ser Leu Leu Glu Thr Leu Ser Pro Glu Glu Met Glu Glu Leu 
            20                  25                  30          


Glu Lys Glu Leu Asp Val Val Asp Pro Asp Gly Ser Val Pro Val Gly 
        35                  40                  45              


Leu Arg Gln Arg Asn Gln Thr Glu Lys Gln Ser Thr Gly Val Tyr Asn 
    50                  55                  60                  


Arg Glu Ala Met Leu Asn Phe Cys Glu Lys Glu Thr Lys Lys Glu Glu 
65                  70                  75                  80  


Glu Lys Lys Gly Ser Asp Arg Asn Thr Gly Leu Ser Arg Asp Lys Asp 
                85                  90                  95      


Lys Lys Arg Glu Glu Met Lys Glu Val Ala Lys Lys Glu Asp Asp Glu 
            100                 105                 110         


Lys Val Lys Gly Glu Arg Arg Asn Thr Asp Thr Arg Lys Glu Gly Glu 
        115                 120                 125             


Lys Met Lys Arg Ala Gly Gly Asn Thr Asp Met Lys Lys Glu Asp Glu 
    130                 135                 140                 


Lys Val Lys Arg Gly Thr Gly Asn Thr Asp Thr Lys Lys Asp Asp Glu 
145                 150                 155                 160 


Lys Val Lys Lys Asn Glu Pro Leu His Glu Lys Glu Ala Lys Asp Asp 
                165                 170                 175     


Ser Lys Thr Lys Thr Pro Glu Lys Gln Thr Pro Ser Gly Pro Thr Lys 
            180                 185                 190         


Pro Ser Glu Gly Pro Ala Lys Val Glu Glu Glu Ala Ala Pro Ser Ile 
        195                 200                 205             


Phe Asp Glu Pro Leu Glu Arg Val Lys Asn Asn Asp Pro Glu Met Thr 
    210                 215                 220                 


Glu Val Asn Val Asn Asn Ser Asp Cys Ile Thr Asn Glu Ile Leu Val 
225                 230                 235                 240 


Arg Phe Thr Glu Ala Leu Glu Phe Asn Thr Val Val Lys Leu Phe Ala 
                245                 250                 255     


Leu Ala Asn Thr Arg Ala Asp Asp His Val Ala Phe Ala Ile Ala Ile 
            260                 265                 270         


Met Leu Lys Ala Asn Lys Thr Ile Thr Ser Leu Asn Leu Asp Ser Asn 
        275                 280                 285             


His Ile Thr Gly Lys Gly Ile Leu Ala Ile Phe Arg Ala Leu Leu Gln 
    290                 295                 300                 


Asn Asn Thr Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Ile Cys 
305                 310                 315                 320 


Gly Gly Lys Thr Glu Met Glu Ile Ala Lys Leu Leu Lys Glu Asn Thr 
                325                 330                 335     


Thr Leu Leu Lys Leu Gly Tyr His Phe Glu Leu Ala Gly Pro Arg Met 
            340                 345                 350         


Thr Val Thr Asn Leu Leu Ser Arg Asn Met Asp Lys Gln Arg Gln Lys 
        355                 360                 365             


Arg Leu Gln Glu Gln Arg Gln Ala Gln Glu Ala Lys Gly Glu Lys Lys 
    370                 375                 380                 


Asp Leu Leu Glu Val Pro Lys Ala Gly Ala Val Ala Lys Gly Ser Pro 
385                 390                 395                 400 


Lys Pro Ser Pro Gln Pro Ser Pro Lys Pro Ser Pro Lys Asn Ser Pro 
                405                 410                 415     


Lys Lys Gly Gly Ala Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Leu 
            420                 425                 430         


Ala Pro Pro Leu Ile Met Glu Asn Leu Lys Asn Ser Leu Ser Pro Ala 
        435                 440                 445             


Thr Gln Arg Lys Met Gly Asp Lys Val Leu Pro Ala Gln Glu Lys Asn 
    450                 455                 460                 


Ser Arg Asp Gln Leu Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln 
465                 470                 475                 480 


Leu Lys Lys Trp Lys Cys Pro Asn Cys Phe Ser Arg Thr Arg Leu Pro 
                485                 490                 495     


Gly Thr Ile Cys Gln Cys His Asp Cys Ser Gly Leu Thr Ser Gln Gly 
            500                 505                 510         


Tyr Thr Asp Pro Ala His Pro Ile Pro Gly 
        515                 520         


<210>  6913
<211>  3945
<212>  DNA
<213>  Homosapiens

<400>  6913
attagaccag ccggggtcca ctagccctgg gcttcaggga ggctgctgcg tccagtgaac     60

acttcagcac ctgtagcaca gaagggccaa ggagctgcag tcctcgacca gcaggaggtt    120

tgctcctcag cccactcgct gcatccagat cagctcaccc ctctcccttc cctgcccacc    180

aggactctga tagcccctgg cagccacagc ccattttgcc aagatgtcta gagtagccaa    240

atatcgccgg caggtgagtg aagaccccga catcgacagc ctgctggaga ccctgtctcc    300

cgaggagatg gaggagctgg agaaggagct ggacgtggtg gacccagacg ggagtgttcc    360

cgtggggctg cggcagagaa accagacgga gaaacagtcc acgggtgtgt acaaccggga    420

ggccatgctc aacttctgtg aaaaggagac caagaaactt atgcagaggg agatgtccat    480

ggatgaaagc aagcaagtgg agaccaagac agatgccaag aatggagagg aaaggggcag    540

agatgccagc aaaaaagccc tgggccccag acgggactca gatctgggga aggagccaaa    600

gaggggtggt ttaaagaaaa gcttctctag agacagagat gaagctggtg gcaagagtgg    660

cgagaagccc aaggaggaga agatcatccg gggcattgac aagggccggg tcagggctgc    720

agtggataag aaggaggcag ggaaggatgg gagaggagag gagagggcag tggccaccaa    780

gaaggaagag gagaagaaag ggagtgacag gaacacaggc ttgagcaggg acaaggataa    840

aaagagagag gagatgaagg aggtggccaa gaaagaggat gatgagaagg taaaagggga    900

gcgtaggaac acagacacca gaaaagaggg tgagaagatg aaaagagcag gtgggaacac    960

agacatgaaa aaggaggatg agaaggtaaa aagaggaact gggaacacag acaccaaaaa   1020

ggacgatgaa aaagtcaaga agaatgaacc cttacatgaa aaggaagcca aggatgacag   1080

caagaccaaa acacccgaga aacagacgcc cagtggcccc accaagccct ctgaaggacc   1140

ggccaaggtg gaggaggagg cagctcccag catatttgat gagcctctgg agagagtgaa   1200

gaacaatgac cccgagatga ctgaggtgaa cgtcaacaac tcagactgca tcacaaatga   1260

gatcttggtc cggtttactg aggctctgga gttcaacact gtggttaagc tgttcgcctt   1320

ggccaacacg cgagccgatg accacgtggc ctttgccatt gccatcatgc tcaaggccaa   1380

caagaccatc accagcctca acctggactc caaccacatc acaggcaaag gcatcctggc   1440

catcttccgg gccctcctcc agaacaacac gctgaccgag ctccgcttcc acaaccagcg   1500

acacatctgt ggaggcaaga cggagatgga gatcgccaag ctgctgaagg agaatactac   1560

cctgctcaag ctgggctacc attttgagct ggccgggccc cgaatgactg tcaccaatct   1620

gctcagccgc aacatggaca agcagagaca aaagcggctg caggagcaaa ggcaggcaca   1680

ggaagccaag ggagagaaga aggatctgct ggaggtaccc aaggccgggg ccgtggctaa   1740

gggctcccca aaaccttcac ctcaaccatc tccaaagccc tctccaaaga actcacccaa   1800

aaaagggggt gctccagctg ccccaccacc ccctccccct cccttggctc caccccttat   1860

catggagaac ctgaagaatt cactctcacc agctacccag aggaagatgg gagacaaagt   1920

cctccctgcc caggagaaga actcccgtga ccagctattg gctgccatcc gctccagcaa   1980

cctcaagcag ctcaagaagt ggaagtgccc aaactgcttc agtaggacca ggctgccagg   2040

caccatctgc caatgccatg actgctcagg cctcacctcc cagggctaca cagaccctgc   2100

ccaccccatc cctggctgac ctgctgtgga tgtccctatt ctgccatggg agagtccagg   2160

cctgggtcac gctcaaggaa ggatgcctta tctcttctca ctttcctttt cttgtctctg   2220

aggctctcca aattttgctt tagtacatgg agctcaggtt tctggacaag aagagtcctt   2280

ttagcacatc actgagaaga tggcactgtc cagggcccat gtagctggca agctgcaaaa   2340

ggcctgtgat ccaggaaaga tgtcccacag ggaccacatc caccccagcc ccactgccct   2400

ccagggccag gattcaggcc tctgaggagc ccacggggca aagctgctgg gccagtggca   2460

ctctgtgtgg gaaaatggca gaaagatgga gaggcatggg ggcccaaagg ggagcgtggg   2520

gaggggctga ggatacccca aagtccaggc taattagagg atgtggcagg ggcagtggcc   2580

tggatgcaca gtgcctgatg ggagtaggct ccagacagga ggagtgggac agacagcagc   2640

tggacttgaa ggtttgatgc caaagcagac attttcctca cacccacctg ctgctgtatg   2700

aatagctgtg tatctgtttt tccataagat tttgataata tatacaaacc tttagctgtg   2760

aatggctgtg ccccacctgt tgtcctgaac tgtgagtcct gatcctaacc ctgggctccc   2820

tggaggactc tagaagctca ggttccctgc cacactattt gagttggcca agaaataaat   2880

tcacatcctc agaaagtgca gcatggagga aaatctgaac tctaagcaga agactctcca   2940

ctgacctggt tgtccaggtc tagaaggcca ggcctctact aggtctgctc ctgaaccagt   3000

cctgctgcct ggagtcagta gccagagttg ttctcagggg tgctggggca gagtggagcc   3060

cagggtgctg ggatggctat attaggcatg ttcagggatg ctcattccat gactctgcct   3120

aaccatgggc tcagggccag gtcctcacag cagtcacagg cccaggaagg cggcaggcag   3180

agaagtggag tgactatttg gagaatagca cccatatctg tgtgccctag ggctcagagg   3240

ggcctcatct tccccagccc tccccacctg ctcaccaatt ccacttcctg ccccaactgc   3300

aggaatgctg acaatgctgc catgcccacc atcgggtgta ggtgaaaggc atctttctga   3360

atttcattct cttgaaggtg ctgccacccc ttggcactgt ggaactgcca ccttgggtct   3420

gtgtcacttg taggtttctc tgcctccagg ttgcctcaac agcaggaggc acagcagttt   3480

caccatcttt gaggtgaggg tggggtgccc cagctaggaa gcaagatcgc tgtgctaggt   3540

ctgaccaaaa ccagagggca gtctagtcct gggggtaaag ccctcagatc ccagggtaca   3600

ctcttctcca ttccctccac ccacttgcct gtcaccccag tcacctaagc aatcactggg   3660

cccagaggag aggagacaga cacacactgg ctcctggacc taaagggtat gagctggagc   3720

taaggccagc tagagcttcc actgtcagcc ctcactgtca gtcccactgc acccccctgt   3780

gcctgctggg cactgggcac tagctagatg ctttaggttg cttcagctga tccttcaact   3840

ctgtgaggtg gataccaata ttctattttg cagatagaat ttggcccaga gaggttaact   3900

aatatatcca tgatcacaca gctaataaaa gtcagagctc aggtc                   3945


<210>  6914
<211>  631
<212>  PRT
<213>  Homosapiens

<400>  6914

Met Ser Arg Val Ala Lys Tyr Arg Arg Gln Val Ser Glu Asp Pro Asp 
1               5                   10                  15      


Ile Asp Ser Leu Leu Glu Thr Leu Ser Pro Glu Glu Met Glu Glu Leu 
            20                  25                  30          


Glu Lys Glu Leu Asp Val Val Asp Pro Asp Gly Ser Val Pro Val Gly 
        35                  40                  45              


Leu Arg Gln Arg Asn Gln Thr Glu Lys Gln Ser Thr Gly Val Tyr Asn 
    50                  55                  60                  


Arg Glu Ala Met Leu Asn Phe Cys Glu Lys Glu Thr Lys Lys Leu Met 
65                  70                  75                  80  


Gln Arg Glu Met Ser Met Asp Glu Ser Lys Gln Val Glu Thr Lys Thr 
                85                  90                  95      


Asp Ala Lys Asn Gly Glu Glu Arg Gly Arg Asp Ala Ser Lys Lys Ala 
            100                 105                 110         


Leu Gly Pro Arg Arg Asp Ser Asp Leu Gly Lys Glu Pro Lys Arg Gly 
        115                 120                 125             


Gly Leu Lys Lys Ser Phe Ser Arg Asp Arg Asp Glu Ala Gly Gly Lys 
    130                 135                 140                 


Ser Gly Glu Lys Pro Lys Glu Glu Lys Ile Ile Arg Gly Ile Asp Lys 
145                 150                 155                 160 


Gly Arg Val Arg Ala Ala Val Asp Lys Lys Glu Ala Gly Lys Asp Gly 
                165                 170                 175     


Arg Gly Glu Glu Arg Ala Val Ala Thr Lys Lys Glu Glu Glu Lys Lys 
            180                 185                 190         


Gly Ser Asp Arg Asn Thr Gly Leu Ser Arg Asp Lys Asp Lys Lys Arg 
        195                 200                 205             


Glu Glu Met Lys Glu Val Ala Lys Lys Glu Asp Asp Glu Lys Val Lys 
    210                 215                 220                 


Gly Glu Arg Arg Asn Thr Asp Thr Arg Lys Glu Gly Glu Lys Met Lys 
225                 230                 235                 240 


Arg Ala Gly Gly Asn Thr Asp Met Lys Lys Glu Asp Glu Lys Val Lys 
                245                 250                 255     


Arg Gly Thr Gly Asn Thr Asp Thr Lys Lys Asp Asp Glu Lys Val Lys 
            260                 265                 270         


Lys Asn Glu Pro Leu His Glu Lys Glu Ala Lys Asp Asp Ser Lys Thr 
        275                 280                 285             


Lys Thr Pro Glu Lys Gln Thr Pro Ser Gly Pro Thr Lys Pro Ser Glu 
    290                 295                 300                 


Gly Pro Ala Lys Val Glu Glu Glu Ala Ala Pro Ser Ile Phe Asp Glu 
305                 310                 315                 320 


Pro Leu Glu Arg Val Lys Asn Asn Asp Pro Glu Met Thr Glu Val Asn 
                325                 330                 335     


Val Asn Asn Ser Asp Cys Ile Thr Asn Glu Ile Leu Val Arg Phe Thr 
            340                 345                 350         


Glu Ala Leu Glu Phe Asn Thr Val Val Lys Leu Phe Ala Leu Ala Asn 
        355                 360                 365             


Thr Arg Ala Asp Asp His Val Ala Phe Ala Ile Ala Ile Met Leu Lys 
    370                 375                 380                 


Ala Asn Lys Thr Ile Thr Ser Leu Asn Leu Asp Ser Asn His Ile Thr 
385                 390                 395                 400 


Gly Lys Gly Ile Leu Ala Ile Phe Arg Ala Leu Leu Gln Asn Asn Thr 
                405                 410                 415     


Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Ile Cys Gly Gly Lys 
            420                 425                 430         


Thr Glu Met Glu Ile Ala Lys Leu Leu Lys Glu Asn Thr Thr Leu Leu 
        435                 440                 445             


Lys Leu Gly Tyr His Phe Glu Leu Ala Gly Pro Arg Met Thr Val Thr 
    450                 455                 460                 


Asn Leu Leu Ser Arg Asn Met Asp Lys Gln Arg Gln Lys Arg Leu Gln 
465                 470                 475                 480 


Glu Gln Arg Gln Ala Gln Glu Ala Lys Gly Glu Lys Lys Asp Leu Leu 
                485                 490                 495     


Glu Val Pro Lys Ala Gly Ala Val Ala Lys Gly Ser Pro Lys Pro Ser 
            500                 505                 510         


Pro Gln Pro Ser Pro Lys Pro Ser Pro Lys Asn Ser Pro Lys Lys Gly 
        515                 520                 525             


Gly Ala Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Leu Ala Pro Pro 
    530                 535                 540                 


Leu Ile Met Glu Asn Leu Lys Asn Ser Leu Ser Pro Ala Thr Gln Arg 
545                 550                 555                 560 


Lys Met Gly Asp Lys Val Leu Pro Ala Gln Glu Lys Asn Ser Arg Asp 
                565                 570                 575     


Gln Leu Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln Leu Lys Lys 
            580                 585                 590         


Trp Lys Cys Pro Asn Cys Phe Ser Arg Thr Arg Leu Pro Gly Thr Ile 
        595                 600                 605             


Cys Gln Cys His Asp Cys Ser Gly Leu Thr Ser Gln Gly Tyr Thr Asp 
    610                 615                 620                 


Pro Ala His Pro Ile Pro Gly 
625                 630     


<210>  6915
<211>  699
<212>  DNA
<213>  Homosapiens

<400>  6915
tgaccgagct ccgcttccac aaccagcgac acatctgtgg aggcaagacg gagatggaga     60

tcgccaagct gctgaaggag aatactaccc tgctcaagct gggctaccat tttgagctgg    120

ccgggccccg aatgactgtc accaatctgc tcagccgcaa catggacaag cagagacaaa    180

agcggctgca ggagcaaagg caggcacagg aagccaaggg agagaagaag gatctgctgg    240

aggtacccaa ggccggggcc gtggctaagg gctccccaaa accttcacct caaccatctc    300

caaagccctc tccaaagaac tcacccaaaa aagggggtgc tccagctgcc ccaccacccc    360

ctccccctcc cttggctcca ccccttatca tggagaacct gaagaattca ctctcaccag    420

ctacccagag gaagatggga gacaaagtcc tccctgccca ggagaagaac tcccgtgacc    480

agctattggc tgccatccgc tccagcaacc tcaagcagct caagaagtgg aagtgcccaa    540

actgctgggc actgggcact agctagatgc tttaggttgc ttcagctgat ccttcaactc    600

tgtgaggtgg ataccaatat tctattttgc agatagaatt tggcccagag aggttaacta    660

atatatccat gatcacacag ctaataaaag tcagagctc                           699


<210>  6916
<211>  170
<212>  PRT
<213>  Homosapiens

<400>  6916

Met Glu Ile Ala Lys Leu Leu Lys Glu Asn Thr Thr Leu Leu Lys Leu 
1               5                   10                  15      


Gly Tyr His Phe Glu Leu Ala Gly Pro Arg Met Thr Val Thr Asn Leu 
            20                  25                  30          


Leu Ser Arg Asn Met Asp Lys Gln Arg Gln Lys Arg Leu Gln Glu Gln 
        35                  40                  45              


Arg Gln Ala Gln Glu Ala Lys Gly Glu Lys Lys Asp Leu Leu Glu Val 
    50                  55                  60                  


Pro Lys Ala Gly Ala Val Ala Lys Gly Ser Pro Lys Pro Ser Pro Gln 
65                  70                  75                  80  


Pro Ser Pro Lys Pro Ser Pro Lys Asn Ser Pro Lys Lys Gly Gly Ala 
                85                  90                  95      


Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Leu Ala Pro Pro Leu Ile 
            100                 105                 110         


Met Glu Asn Leu Lys Asn Ser Leu Ser Pro Ala Thr Gln Arg Lys Met 
        115                 120                 125             


Gly Asp Lys Val Leu Pro Ala Gln Glu Lys Asn Ser Arg Asp Gln Leu 
    130                 135                 140                 


Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln Leu Lys Lys Trp Lys 
145                 150                 155                 160 


Cys Pro Asn Cys Trp Ala Leu Gly Thr Ser 
                165                 170 


<210>  6917
<211>  526
<212>  DNA
<213>  Homosapiens

<400>  6917
cagcacctgt agcacagaag ggccaaggag ctgcagtcct cgaccagcag gaggtttgct     60

cctcagccca ctcgctgcat ccagatcagc tcacccctct cccttccctg cccaccagga    120

ctctgatagc ccctggcagc cacagcccat tttgccaaga tgtctagagt agccaaatat    180

cgccggcagg tgagtgaaga ccccgacatc gacagcctgc tggagaccct gtctcccgag    240

gagatggagg agctggagaa ggagctggac gtggtggacc cagacgggag tgttcccgtg    300

gggctgcggc agagaaacca gacggagaaa cagtccacgg gtgtgtacaa ccgggaggcc    360

atgctcaact tctgtgaaaa ggagaccaag aaacttatgc agagggagat gtccatggat    420

gtgagtgagc acagtggata ccaatattct attttgcaga tagaatttgg cccagagagg    480

ttaactaata tatccatgat cacacagcta ataaaagtca gagctc                   526


<210>  6918
<211>  121
<212>  PRT
<213>  Homosapiens

<400>  6918

Met Ser Arg Val Ala Lys Tyr Arg Arg Gln Val Ser Glu Asp Pro Asp 
1               5                   10                  15      


Ile Asp Ser Leu Leu Glu Thr Leu Ser Pro Glu Glu Met Glu Glu Leu 
            20                  25                  30          


Glu Lys Glu Leu Asp Val Val Asp Pro Asp Gly Ser Val Pro Val Gly 
        35                  40                  45              


Leu Arg Gln Arg Asn Gln Thr Glu Lys Gln Ser Thr Gly Val Tyr Asn 
    50                  55                  60                  


Arg Glu Ala Met Leu Asn Phe Cys Glu Lys Glu Thr Lys Lys Leu Met 
65                  70                  75                  80  


Gln Arg Glu Met Ser Met Asp Val Ser Glu His Ser Gly Tyr Gln Tyr 
                85                  90                  95      


Ser Ile Leu Gln Ile Glu Phe Gly Pro Glu Arg Leu Thr Asn Ile Ser 
            100                 105                 110         


Met Ile Thr Gln Leu Ile Lys Val Arg 
        115                 120     


<210>  6919
<211>  2095
<212>  DNA
<213>  Homosapiens

<400>  6919
gtgacaggaa cacaggcttg agcagggaca aggataaaaa gagagaggag atgaaggagg     60

tggccaagaa agaggatgat gagaaggtaa aaggggagcg taggaacaca gacaccagaa    120

aagagggtga gaagatgaaa agagcaggtg ggaacacaga catgaaaaag gaggatgaga    180

aggtaaaaag aggaactggg aacacagaca ccaaaaagga cgatgaaaaa gtcaagaaga    240

atgaaccctt acatgaaaag gaagccaagg atgacagcaa gaccaaaaca cccgagaaac    300

agacgcccag tggccccacc aagccctctg aaggaccggc caaggtggag gaggaggcag    360

ctcccagcat atttgatgag cctctggaga gagtgaagaa caatgacccc gagatgactg    420

aggtgaacgt caacaactca gactgcatca caaatgagat cttggtccgg tttactgagg    480

ctctggagtt caacactgtg gttaagctgt tcgccttggc caacacgcga gccgatgacc    540

acgtggcctt tgccattgcc atcatgctca aggccaacaa gaccatcacc agcctcaacc    600

tggactccaa ccacatcaca ggcaaaggca tcctggccat cttccgggcc ctcctccaga    660

acaacacgct gaccgagctc cgcttccaca accagcgaca catctgtgga ggcaagacgg    720

agatggagat cgccaagctg ctgaaggaga atactaccct gctcaagctg ggctaccatt    780

ttgagctggc cgggccccga atgactgtca ccaatctgct cagccgcaac atggacaagc    840

agagacaaaa gcggctgcag gagcaaaggc aggcacagga agccaaggga gagaagaagg    900

atctgctgga ggtacccaag gccggggccg tggctaaggg ctccccaaaa ccttcacctc    960

aaccatctcc aaagccctct ccaaagaact cacccaaaaa agggggtgct ccagctgccc   1020

caccaccccc tccccctccc ttggctccac cccttatcat ggagaacctg aagaattcac   1080

tctcaccagc tacccagagg aagatgggag acaaagtcct ccctgcccag gagaagaact   1140

cccgtgacca gctattggct gccatccgct ccagcaacct caagcagctc aagaagtgga   1200

agtgcccaaa ctgcttcagt aggaccaggc tgccaggcac catctgccaa tgccatgact   1260

gctcaggcct cacctcccag ggctacacag accctgccca ccccatccct ggctgacctg   1320

ctgtggatgt ccctattctg ccatgggaga gtccaggcct gggtcacgct caaggaagga   1380

tgccttatct cttctcactt tccttttctt gtctctgagg ctctccaaat tttgctttag   1440

tacatggagc tcaggtttct ggacaagaag agtcctttta gcacatcact gagaagatgg   1500

cactgtccag ggcccatgta gctggcaagc tgcaaaaggc ctgtgatcca ggaaagatgt   1560

cccacaggga ccacatccac cccagcccca ctgccctcca gggccaggat tcaggcctct   1620

gaggagccca cggggcaaag ctgctgggcc agtggcactc tgtgtgggaa aatggcagaa   1680

agatggagag gcatgggggc ccaaagggga gcgtggggag gggctgagga taccccaaag   1740

tccaggctaa ttagaggatg tggcaggggc agtggcctgg atgcacagtg cctgatggga   1800

gtaggctcca gacaggagga gtgggacaga cagcagctgg acttgaaggt ttgatgccaa   1860

agcagacatt ttcctcacac ccacctgctg ctgtatgaat agctgtgtat ctgtttttcc   1920

ataagatttt gataatatat acaaaccttt agctgtgaat ggctgtgccc cacctgttgt   1980

cctgaactgt gagtcctgat cctaaccctg ggctccctgg aggactctag aagctcaggt   2040

tccctgccac actatttgag ttggccaaga aataaattca catcctcaga aagtg        2095


<210>  6920
<211>  421
<212>  PRT
<213>  Homosapiens

<400>  6920

Met Lys Glu Val Ala Lys Lys Glu Asp Asp Glu Lys Val Lys Gly Glu 
1               5                   10                  15      


Arg Arg Asn Thr Asp Thr Arg Lys Glu Gly Glu Lys Met Lys Arg Ala 
            20                  25                  30          


Gly Gly Asn Thr Asp Met Lys Lys Glu Asp Glu Lys Val Lys Arg Gly 
        35                  40                  45              


Thr Gly Asn Thr Asp Thr Lys Lys Asp Asp Glu Lys Val Lys Lys Asn 
    50                  55                  60                  


Glu Pro Leu His Glu Lys Glu Ala Lys Asp Asp Ser Lys Thr Lys Thr 
65                  70                  75                  80  


Pro Glu Lys Gln Thr Pro Ser Gly Pro Thr Lys Pro Ser Glu Gly Pro 
                85                  90                  95      


Ala Lys Val Glu Glu Glu Ala Ala Pro Ser Ile Phe Asp Glu Pro Leu 
            100                 105                 110         


Glu Arg Val Lys Asn Asn Asp Pro Glu Met Thr Glu Val Asn Val Asn 
        115                 120                 125             


Asn Ser Asp Cys Ile Thr Asn Glu Ile Leu Val Arg Phe Thr Glu Ala 
    130                 135                 140                 


Leu Glu Phe Asn Thr Val Val Lys Leu Phe Ala Leu Ala Asn Thr Arg 
145                 150                 155                 160 


Ala Asp Asp His Val Ala Phe Ala Ile Ala Ile Met Leu Lys Ala Asn 
                165                 170                 175     


Lys Thr Ile Thr Ser Leu Asn Leu Asp Ser Asn His Ile Thr Gly Lys 
            180                 185                 190         


Gly Ile Leu Ala Ile Phe Arg Ala Leu Leu Gln Asn Asn Thr Leu Thr 
        195                 200                 205             


Glu Leu Arg Phe His Asn Gln Arg His Ile Cys Gly Gly Lys Thr Glu 
    210                 215                 220                 


Met Glu Ile Ala Lys Leu Leu Lys Glu Asn Thr Thr Leu Leu Lys Leu 
225                 230                 235                 240 


Gly Tyr His Phe Glu Leu Ala Gly Pro Arg Met Thr Val Thr Asn Leu 
                245                 250                 255     


Leu Ser Arg Asn Met Asp Lys Gln Arg Gln Lys Arg Leu Gln Glu Gln 
            260                 265                 270         


Arg Gln Ala Gln Glu Ala Lys Gly Glu Lys Lys Asp Leu Leu Glu Val 
        275                 280                 285             


Pro Lys Ala Gly Ala Val Ala Lys Gly Ser Pro Lys Pro Ser Pro Gln 
    290                 295                 300                 


Pro Ser Pro Lys Pro Ser Pro Lys Asn Ser Pro Lys Lys Gly Gly Ala 
305                 310                 315                 320 


Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Leu Ala Pro Pro Leu Ile 
                325                 330                 335     


Met Glu Asn Leu Lys Asn Ser Leu Ser Pro Ala Thr Gln Arg Lys Met 
            340                 345                 350         


Gly Asp Lys Val Leu Pro Ala Gln Glu Lys Asn Ser Arg Asp Gln Leu 
        355                 360                 365             


Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln Leu Lys Lys Trp Lys 
    370                 375                 380                 


Cys Pro Asn Cys Phe Ser Arg Thr Arg Leu Pro Gly Thr Ile Cys Gln 
385                 390                 395                 400 


Cys His Asp Cys Ser Gly Leu Thr Ser Gln Gly Tyr Thr Asp Pro Ala 
                405                 410                 415     


His Pro Ile Pro Gly 
            420     


<210>  6921
<211>  2013
<212>  DNA
<213>  Homosapiens

<400>  6921
gttgtcgggt cttattggcc gctgattaga ccagccgggg tccactagcc ctgggcttca     60

gggaggctgc tgcgtccagt gaacacttca gcacctgtag cacagaaggg ccaaggagct    120

gcagtcctcg accagcagga ggtttgctcc tcagcccact cgctgcatcc agatcagctc    180

acccctctcc cttccctgcc caccaggact ctgatagccc ctggcagcca cagcccattt    240

tgccaagatg tctagagtag ccaaatatcg ccggcaggtg agtgaagacc ccgacatcga    300

cagcctgctg gagaccctgt ctcccgagga gatggaggag ctggagaagg agctggacgt    360

ggtggaccca gacgggagtg ttcccgtggg gctgcggcag agaaaccaga cggagaaaca    420

gtccacgggt gtgtacaacc gggaggccat gctcaacttc tgtgaaaagg agaccaagaa    480

acttatgcag agggagatgt ccatggatga aagcaagcaa gtggagacca agacagatgc    540

caagaatgga gaggaaaggg gcagagatgc cagcaaaaaa gccctgggcc ccagacggga    600

ctcagatctg gggaaggagc caaagagggg tggtttaaag aaaagcttct ctagagacag    660

agatgaagct ggtggcaaga gtggcgagaa gcccaaggag gagaagatca tccggggcat    720

tgacaagggc cgggtcaggg ctgcagtgga taagaaggag gcagggaagg atgggagagg    780

agaggagagg gcagtggcca ccaagaagga agaggagaag aaagggagtg acaggaacac    840

aggcttgagc agggacaagg ataaaaagag agaggagatg aaggaggtgg ccaagaaaga    900

ggatgatgag aaggtaaaag ggggtgctcc agctgcccca ccaccccctc cccctccctt    960

ggctccaccc cttatcatgg agaacctgaa gaattcactc tcaccagcta cccagaggaa   1020

gatgggagac aaagtcctcc ctgcccagga gaagaactcc cgtgaccagc tattggctgc   1080

catccgctcc agcaacctca agcagctcaa gaagtggaag tgcccaaact gcttcagtag   1140

gaccaggctg ccaggcacca tctgccaatg ccatgactgc tcaggcctca cctcccaggg   1200

ctacacagac cctgcccacc ccatccctgg ctgacctgct gtggatgtcc ctattctgcc   1260

atgggagagt ccaggcctgg gtcacgctca aggaaggatg ccttatctct tctcactttc   1320

cttttcttgt ctctgaggct ctccaaattt tgctttagta catggagctc aggtttctgg   1380

acaagaagag tccttttagc acatcactga gaagatggca ctgtccaggg cccatgtagc   1440

tggcaagctg caaaaggcct gtgatccagg aaagatgtcc cacagggacc acatccaccc   1500

cagccccact gccctccagg gccaggattc aggcctctga ggagcccacg gggcaaagct   1560

gctgggccag tggcactctg tgtgggaaaa tggcagaaag atggagaggc atgggggccc   1620

aaaggggagc gtggggaggg gctgaggata ccccaaagtc caggctaatt agaggatgtg   1680

gcaggggcag tggcctggat gcacagtgcc tgatgggagt aggctccaga caggaggagt   1740

gggacagaca gcagctggac ttgaaggttt gatgccaaag cagacatttt cctcacaccc   1800

acctgctgct gtatgaatag ctgtgtatct gtttttccat aagattttga taatatatac   1860

aaacctttag ctgtgaatgg ctgtgcccca cctgttgtcc tgaactgtga gtcctgatcc   1920

taaccctggg ctccctggag gactctagaa gctcaggttc cctgccacac tatttgagtt   1980

ggccaagaaa taaattcaca tcctcagaaa gtg                                2013


<210>  6922
<211>  328
<212>  PRT
<213>  Homosapiens

<400>  6922

Met Ser Arg Val Ala Lys Tyr Arg Arg Gln Val Ser Glu Asp Pro Asp 
1               5                   10                  15      


Ile Asp Ser Leu Leu Glu Thr Leu Ser Pro Glu Glu Met Glu Glu Leu 
            20                  25                  30          


Glu Lys Glu Leu Asp Val Val Asp Pro Asp Gly Ser Val Pro Val Gly 
        35                  40                  45              


Leu Arg Gln Arg Asn Gln Thr Glu Lys Gln Ser Thr Gly Val Tyr Asn 
    50                  55                  60                  


Arg Glu Ala Met Leu Asn Phe Cys Glu Lys Glu Thr Lys Lys Leu Met 
65                  70                  75                  80  


Gln Arg Glu Met Ser Met Asp Glu Ser Lys Gln Val Glu Thr Lys Thr 
                85                  90                  95      


Asp Ala Lys Asn Gly Glu Glu Arg Gly Arg Asp Ala Ser Lys Lys Ala 
            100                 105                 110         


Leu Gly Pro Arg Arg Asp Ser Asp Leu Gly Lys Glu Pro Lys Arg Gly 
        115                 120                 125             


Gly Leu Lys Lys Ser Phe Ser Arg Asp Arg Asp Glu Ala Gly Gly Lys 
    130                 135                 140                 


Ser Gly Glu Lys Pro Lys Glu Glu Lys Ile Ile Arg Gly Ile Asp Lys 
145                 150                 155                 160 


Gly Arg Val Arg Ala Ala Val Asp Lys Lys Glu Ala Gly Lys Asp Gly 
                165                 170                 175     


Arg Gly Glu Glu Arg Ala Val Ala Thr Lys Lys Glu Glu Glu Lys Lys 
            180                 185                 190         


Gly Ser Asp Arg Asn Thr Gly Leu Ser Arg Asp Lys Asp Lys Lys Arg 
        195                 200                 205             


Glu Glu Met Lys Glu Val Ala Lys Lys Glu Asp Asp Glu Lys Val Lys 
    210                 215                 220                 


Gly Gly Ala Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Leu Ala Pro 
225                 230                 235                 240 


Pro Leu Ile Met Glu Asn Leu Lys Asn Ser Leu Ser Pro Ala Thr Gln 
                245                 250                 255     


Arg Lys Met Gly Asp Lys Val Leu Pro Ala Gln Glu Lys Asn Ser Arg 
            260                 265                 270         


Asp Gln Leu Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln Leu Lys 
        275                 280                 285             


Lys Trp Lys Cys Pro Asn Cys Phe Ser Arg Thr Arg Leu Pro Gly Thr 
    290                 295                 300                 


Ile Cys Gln Cys His Asp Cys Ser Gly Leu Thr Ser Gln Gly Tyr Thr 
305                 310                 315                 320 


Asp Pro Ala His Pro Ile Pro Gly 
                325             


<210>  6923
<211>  1957
<212>  DNA
<213>  Homosapiens

<400>  6923
gtgacaggaa cacaggcttg agcagggaca aggataaaaa gagagaggag atgaaggagg     60

tggccaagaa agaggatgat gagaaggtaa aaggggagcg taggaacaca gacaccagaa    120

aagagggtga gaagatgaaa agagcaggtg ggaacacaga catgaaaaag gaggatgaga    180

aggtaaaaag aggaactggg aacacagaca ccaaaaagga cgatgaaaaa gtcaagaaga    240

atgaaccctt acatgaaaag gaagccaagg atgacagcaa gaccaaaaca cccgagaaac    300

agacgcccag tggccccacc aagccctctg aaggaccggc caaggtggag gaggaggcag    360

ctcccagcat atttgatgag cctctggaga gagtgaagaa caatgacccc gagatgactg    420

aggtgaacgt caacaactca gactgcatca caaatgagat cttggtccgg tttactgagg    480

ctctggagtt caacactgtg gttaagctgt tcgccttggc caacacgcga gccgatgacc    540

acgtggcctt tgccattgcc atcatgctca aggccaacaa gaccatcacc agcctcaacc    600

tggactccaa ccacatcaca ggcaaaggca tcctggccat cttccgggcc ctcctccaga    660

acaacacgct gaccgagctc cgcttccaca accagcgaca catctgtgga ggcaagacgg    720

agatggagat cgccaagctg ctgaaggaga atactaccct gctcaagctg ggctaccatt    780

ttgagctggc cgggccccga atgactgtca ccaatctgct cagccgcaac atggacaagc    840

agagacaaaa gcggctgcag gagcaaaggc aggcacagga agccaaggga gagaagaagg    900

atctgctgga ggtacccaag gccggggccg tggctaaggg ctccccaaaa ccttcacctc    960

aaccatctcc aaagccctct ccaaagaact cacccaaaaa agggggtgct ccagctgccc   1020

caccaccccc tccccctccc ttggctccac cccttatcat ggagaacctg aagaattcac   1080

tctcaccagc tacccagagg aagatgggag acaaagtcct ccctgcccag gagaagaact   1140

cccgtgacca gctattggct gccatccgct ccagcaacct caagcagctc aagaagtgga   1200

agtgcccaaa ctgcttcagt aggaccaggc tgccaggcac catctgccaa tgccatgact   1260

gctcaggcct cacctcccag ggctacacag accctgccca ccccatccct ggctgacctg   1320

ctgtggatgt ccctattctg ccatgggaga gtccaggcct gggtcacgct caaggaagga   1380

tgccttatct cttctcactt tccttttctt gtctctgagg ctctccaaat tttgctttag   1440

tacatggagc tcaggtttct ggacaagaag agtcctttta gcacatcact gagaagatgg   1500

cactgtccag ggcccatgta gctggcaagc tgcaaaaggc ctgtgatcca ggaaagatgt   1560

cccacaggga ccacatccac cccagcccca ctgccctcca gggccaggat tcaggcctct   1620

gaggagccca cggggcaaag ctgctgggcc agtggcactc tgtgtgggaa aatggcagaa   1680

agatggagag gcatgggggc ccaaagggga gcgtggggag gggctgagga taccccaaag   1740

tccaggctaa ttagaggatg tggcaggggc agtggcctgg atgcacagtg cctgatggga   1800

gtaggctcca gacaggagga gtgggacaga cagcagctgg acttgaaggt ttgatgccaa   1860

agcagacatt ttcctcacac ccacctgctg ctgtatgaat agctgtgtat ctgtttttcc   1920

ataagatttt gataatatat acaaaccttt agctgtg                            1957


<210>  6924
<211>  421
<212>  PRT
<213>  Homosapiens

<400>  6924

Met Lys Glu Val Ala Lys Lys Glu Asp Asp Glu Lys Val Lys Gly Glu 
1               5                   10                  15      


Arg Arg Asn Thr Asp Thr Arg Lys Glu Gly Glu Lys Met Lys Arg Ala 
            20                  25                  30          


Gly Gly Asn Thr Asp Met Lys Lys Glu Asp Glu Lys Val Lys Arg Gly 
        35                  40                  45              


Thr Gly Asn Thr Asp Thr Lys Lys Asp Asp Glu Lys Val Lys Lys Asn 
    50                  55                  60                  


Glu Pro Leu His Glu Lys Glu Ala Lys Asp Asp Ser Lys Thr Lys Thr 
65                  70                  75                  80  


Pro Glu Lys Gln Thr Pro Ser Gly Pro Thr Lys Pro Ser Glu Gly Pro 
                85                  90                  95      


Ala Lys Val Glu Glu Glu Ala Ala Pro Ser Ile Phe Asp Glu Pro Leu 
            100                 105                 110         


Glu Arg Val Lys Asn Asn Asp Pro Glu Met Thr Glu Val Asn Val Asn 
        115                 120                 125             


Asn Ser Asp Cys Ile Thr Asn Glu Ile Leu Val Arg Phe Thr Glu Ala 
    130                 135                 140                 


Leu Glu Phe Asn Thr Val Val Lys Leu Phe Ala Leu Ala Asn Thr Arg 
145                 150                 155                 160 


Ala Asp Asp His Val Ala Phe Ala Ile Ala Ile Met Leu Lys Ala Asn 
                165                 170                 175     


Lys Thr Ile Thr Ser Leu Asn Leu Asp Ser Asn His Ile Thr Gly Lys 
            180                 185                 190         


Gly Ile Leu Ala Ile Phe Arg Ala Leu Leu Gln Asn Asn Thr Leu Thr 
        195                 200                 205             


Glu Leu Arg Phe His Asn Gln Arg His Ile Cys Gly Gly Lys Thr Glu 
    210                 215                 220                 


Met Glu Ile Ala Lys Leu Leu Lys Glu Asn Thr Thr Leu Leu Lys Leu 
225                 230                 235                 240 


Gly Tyr His Phe Glu Leu Ala Gly Pro Arg Met Thr Val Thr Asn Leu 
                245                 250                 255     


Leu Ser Arg Asn Met Asp Lys Gln Arg Gln Lys Arg Leu Gln Glu Gln 
            260                 265                 270         


Arg Gln Ala Gln Glu Ala Lys Gly Glu Lys Lys Asp Leu Leu Glu Val 
        275                 280                 285             


Pro Lys Ala Gly Ala Val Ala Lys Gly Ser Pro Lys Pro Ser Pro Gln 
    290                 295                 300                 


Pro Ser Pro Lys Pro Ser Pro Lys Asn Ser Pro Lys Lys Gly Gly Ala 
305                 310                 315                 320 


Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Leu Ala Pro Pro Leu Ile 
                325                 330                 335     


Met Glu Asn Leu Lys Asn Ser Leu Ser Pro Ala Thr Gln Arg Lys Met 
            340                 345                 350         


Gly Asp Lys Val Leu Pro Ala Gln Glu Lys Asn Ser Arg Asp Gln Leu 
        355                 360                 365             


Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln Leu Lys Lys Trp Lys 
    370                 375                 380                 


Cys Pro Asn Cys Phe Ser Arg Thr Arg Leu Pro Gly Thr Ile Cys Gln 
385                 390                 395                 400 


Cys His Asp Cys Ser Gly Leu Thr Ser Gln Gly Tyr Thr Asp Pro Ala 
                405                 410                 415     


His Pro Ile Pro Gly 
            420     


<210>  6925
<211>  947
<212>  DNA
<213>  Homosapiens

<400>  6925
gtccagctgc tgtctgtccc actcctcctg tctggagcct actcccatca ggcactgtgc     60

atccaggcca ctgcccctgc cacatcctct aattagcctg gactttgggg tatcctcagc    120

ccctccccac gctccccttt gggcccccat gcctctccat ctttctgcca ttttcccaca    180

cagagtgcca ctggcccagc agctttgccc cgtgggctcc tcagaggcct gaatcctggc    240

cctggagggc agtggggctg gggtggatgt ggtccctgtg ggacatcttt cctggatcac    300

aggccttttg cagcttgcca gctacatggg ccctggacag tgccatcttc tcagtgatgt    360

gctaaaagga ctcttcttgt ccagaaacct gagctccatg tactaaagca aaatttggag    420

agcctcagag acaagaaaag gaaagtgaga agagataagg catccttcct tgagcgtgac    480

ccaggcctgg actctcccat ggcagaatag ggacatccac agcagtccta ccctctcctc    540

caggccctac ccagccccgc cctgttggct catgcccaca actacttaac ttcttgagct    600

gcttgaggtt gctggagcgg atggcagcca atagctggtc acgggagttc ttctcctggg    660

cagggaggac tttgtctccc atcttcctct gggtagctga tgtgtcgctg gttgtggaag    720

cggagctcgg tcagcgtgtt gttctggagg agggcccgga agatggccag gatgcctttg    780

cctgtgatgt ggttggagtc caggttgagg ctggtgatgg tcttgttggc cttgagcatg    840

atggcaatgg caaaggccac gtggtcatcg gctcgcgtgt tggccaaggc gaacagctta    900

accacagtgt tgaactccag agcctcagta aaccggacca agatctc                  947


<210>  6926
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  6926

Met Ala Ala Asn Ser Trp Ser Arg Glu Phe Phe Ser Trp Ala Gly Arg 
1               5                   10                  15      


Thr Leu Ser Pro Ile Phe Leu Trp Val Ala Asp Val Ser Leu Val Val 
            20                  25                  30          


Glu Ala Glu Leu Gly Gln Arg Val Val Leu Glu Glu Gly Pro Glu Asp 
        35                  40                  45              


Gly Gln Asp Ala Phe Ala Cys Asp Val Val Gly Val Gln Val Glu Ala 
    50                  55                  60                  


Gly Asp Gly Leu Val Gly Leu Glu His Asp Gly Asn Gly Lys Gly His 
65                  70                  75                  80  


Val Val Ile Gly Ser Arg Val Gly Gln Gly Glu Gln Leu Asn His Ser 
                85                  90                  95      


Val Glu Leu Gln Ser Leu Ser Lys Pro Asp Gln Asp 
            100                 105             


<210>  6927
<211>  945
<212>  DNA
<213>  Homosapiens

<400>  6927
agcttgcccg gcatcactcg cggcattgga gtcaagatgg aggagtacgc gcgagagcct     60

tgcccatggc gaattgtgga tgactgtggt ggggccttta cgatgggtac cattggtggt    120

ggtatctttc aagcaatcaa aggttttcgc aattctccag tgggagtaaa ccacagacta    180

cgagggagtt tgacagctat taaaaccagg gctccacagt taggaggtag ctttgcagtt    240

tggggagggc tgttttccat gattgactgt agtatggttc aagtcagagg aaaggaagat    300

ccctggaact ccatcacaag tggtgcctta acgggagcca tactggcagc aagaaatgga    360

ccagtggcca tggttgggtc agccgcaatg ggtggcattc tcctagcttt aattgaagga    420

gctggtatct tgttgacaag atttgcctct gcacagtttc ccaatggtcc tcagtttgca    480

gaagacccct cccagttgcc ttcaactcag ttaccttcct caccttttgg agactatcga    540

caatatcagt aggacttctt tcctaggatt tctttaacag aacgagttgt ggttcgagaa    600

ggatttcaga agatcaagtt acagtctgtt tttaaaacca taggtgggac agctatggcc    660

aataggctat aaagagacat ttagcacttt tttctattta aaggaacaag cggggaaggg    720

tgctaaaaga taatacgttt atttattcac acttgaattg catttgtgat caaaataaat    780

gtttaaatcg ctaaaggaaa atacagtaag tgcttgaaag atgaaggacc aaaaggccaa    840

aaaacagtga aatatgatca tcatctcctt gcggacttct ctgcctggtt ttgtgtgttc    900

tgttattcaa acaataaaaa gctggtggaa cttactcttt ctttt                    945


<210>  6928
<211>  171
<212>  PRT
<213>  Homosapiens

<400>  6928

Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val Asp Asp 
1               5                   10                  15      


Cys Gly Gly Ala Phe Thr Met Gly Thr Ile Gly Gly Gly Ile Phe Gln 
            20                  25                  30          


Ala Ile Lys Gly Phe Arg Asn Ser Pro Val Gly Val Asn His Arg Leu 
        35                  40                  45              


Arg Gly Ser Leu Thr Ala Ile Lys Thr Arg Ala Pro Gln Leu Gly Gly 
    50                  55                  60                  


Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Met Ile Asp Cys Ser Met 
65                  70                  75                  80  


Val Gln Val Arg Gly Lys Glu Asp Pro Trp Asn Ser Ile Thr Ser Gly 
                85                  90                  95      


Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg Asn Gly Pro Val Ala Met 
            100                 105                 110         


Val Gly Ser Ala Ala Met Gly Gly Ile Leu Leu Ala Leu Ile Glu Gly 
        115                 120                 125             


Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser Ala Gln Phe Pro Asn Gly 
    130                 135                 140                 


Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu Pro Ser Thr Gln Leu Pro 
145                 150                 155                 160 


Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr Gln 
                165                 170     


<210>  6929
<211>  1352
<212>  DNA
<213>  Homosapiens

<400>  6929
agcttgcccg gcatcactcg cggcattgga gtcaagatgg aggagtacgc gcgagagcct     60

tgcccatggc gaattgtgga tgactgtggt ggggccttta cgatgggtac cattggtggt    120

ggtatctttc aagcaatcaa aggttttcgc aattctccag tgggagtaaa ccacagacta    180

cgagggagtt tgacagctat taaaaccagg gctccacagt taggaggtag ctttgcagtt    240

tggggagggc tgttttccat gattgactgt agtatggttc aagtcagagg aaaggaagat    300

ccctggaact ccatcacaag tggtgcctta acgggagcca tactggcagc aagaaatgga    360

ccagtggcca tggttgggtc agccgcaatg ggtggcattc tcctagcttt aattgaagga    420

gctggtatct tgttgacaag atttgcctct gcacagtttc ccaatggtcc tcagtttgca    480

gaagacccct cccagttgcc ttcaactcag ttaccttcct caccttttgg agactatcga    540

caatatcagt aggacttctt tcctaggatt tctttaacag aacgagttgt ggttcgagaa    600

ggatttcaga agatcaagtt acagtctgtt tttaaaacca taggtgggac agctatggcc    660

aataggctat aaagagacat ttagcacttt tttctattta aaggaacaag cggggaaggg    720

tgctaaaaga taatacgttt atttattcac acttgaattg catttgtgat caaaataaat    780

gtttaaatcg ctaaaggaaa atacagtaag tgcttgaaag atgaaggacc aaaaggccaa    840

aaaacagtga aatatgatca tcatctcctt gcggacttct ctgcctggtt ttgtgtgttc    900

tgttattcaa acaataaaaa gctggtggaa cttactcttt cttttaagat aagttgtaga    960

cttcgatgtt tcatgctcat gtacttcaaa taatgcatgt tttatagtta gtccctcatc   1020

acttgaagtg acttctgaga attatgcaga gtcaacatgg atcatttcac agtgagatgc   1080

tttatggatt gaaggatatg gtaaaatgtt tatagtttac tttgaaagta aaatatacta   1140

tgtcttggtt ttgaggatat tggatacaaa actctcttcc tttagggcta ctgagtcttg   1200

attcctgatc atcagaaatt tcaccagaaa caacttgctt ccaatatacc caattctata   1260

tgaagaattc atggagagtg tactggcact ggaagagttt agtgtttctt gtatgcttga   1320

aaataaagta tgtactgttt tgaatgtgtt cc                                 1352


<210>  6930
<211>  171
<212>  PRT
<213>  Homosapiens

<400>  6930

Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val Asp Asp 
1               5                   10                  15      


Cys Gly Gly Ala Phe Thr Met Gly Thr Ile Gly Gly Gly Ile Phe Gln 
            20                  25                  30          


Ala Ile Lys Gly Phe Arg Asn Ser Pro Val Gly Val Asn His Arg Leu 
        35                  40                  45              


Arg Gly Ser Leu Thr Ala Ile Lys Thr Arg Ala Pro Gln Leu Gly Gly 
    50                  55                  60                  


Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Met Ile Asp Cys Ser Met 
65                  70                  75                  80  


Val Gln Val Arg Gly Lys Glu Asp Pro Trp Asn Ser Ile Thr Ser Gly 
                85                  90                  95      


Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg Asn Gly Pro Val Ala Met 
            100                 105                 110         


Val Gly Ser Ala Ala Met Gly Gly Ile Leu Leu Ala Leu Ile Glu Gly 
        115                 120                 125             


Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser Ala Gln Phe Pro Asn Gly 
    130                 135                 140                 


Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu Pro Ser Thr Gln Leu Pro 
145                 150                 155                 160 


Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr Gln 
                165                 170     


<210>  6931
<211>  1658
<212>  DNA
<213>  Homosapiens

<400>  6931
agcttgcccg gcatcactcg cggcattgga gtcaagatgg aggagtacgc gcgagagcct     60

tgcccatggc gaattgtgga tgactgtggt ggggccttta cgatgggtac cattggtggt    120

ggtatctttc aagcaatcaa aggttttcgc aattctccag tgggagtaaa ccacagacta    180

cgagggagtt tgacagctat taaaaccagg gctccacagt taggaggtag ctttgcagtt    240

tggggagggc tgttttccat gattgactgt agtatggttc aagtcagagg aaaggaagat    300

ccctggaact ccatcacaag tggtgcctta acgggagcca tactggcagc aagaaatgga    360

ccagtggcca tggttgggtc agccgcaatg ggtggcattc tcctagcttt aattgaagga    420

gctggtatct tgttgacaag atttgcctct gcacagtttc ccaatggtcc tcagtttgca    480

gaagacccct cccagttgcc ttcaactcag ttaccttcct caccttttgg agactatcga    540

caatatcagt aggacttctt tcctaggatt tctttaacag aacgagttgt ggttcgagaa    600

ggatttcaga agatcaagtt acagtctgtt tttaaaacca taggtgggac agctatggcc    660

aataggctat aaagagacat ttagcacttt tttctattta aaggaacaag cggggaaggg    720

tgctaaaaga taatacgttt atttattcac acttgaattg catttgtgat caaaataaat    780

gtttaaatcg ctaaaggaaa atacagtaag tgcttgaaag atgaaggacc aaaaggccaa    840

aaaacagtga aatatgatca tcatctcctt gcggacttct ctgcctggtt ttgtgtgttc    900

tgttattcaa acaataaaaa gctggtggaa cttactcttt cttttaagat aagttgtaga    960

cttcgatgtt tcatgctcat gtacttcaaa taatgcatgt tttatagtta gtccctcatc   1020

acttgaagtg acttctgaga attatgcaga gtcaacatgg atcatttcac agtgagatgc   1080

tttatggatt gaaggatatg gtaaaatgtt tatagtttac tttgaaagta aaatatacta   1140

tgtcttggtt ttgaggatat tggatacaaa actctcttcc tttagggcta ctgagtcttg   1200

attcctgatc atcagaaatt tcaccagaaa caacttgctt ccaatatacc caattctata   1260

tgaagaattc atggagagtg tactggcact ggaagagttt agtgtttctt gtatgcttga   1320

aaataaagta tgtactgttt tgaatgtgtt ccaagtcctc tgcataaacg atgtattttg   1380

gggtctggtt gggcctggaa aatggatgag cacttcagaa caggtcattt tcctgatatt   1440

ggaagtgaca tgtggcccta taggaggcat gatgttagtt aattacacat ttgcctacat   1500

ctgtgggaaa tggagaacaa agccatgtgg gtactgtaaa cacacgttta tcttttggcc   1560

caatgccata catatggtag gcatttaatt actgattgtg tttggataat ttgggaattt   1620

tcgactgtgg taaaatatac ataaaataat acttatta                           1658


<210>  6932
<211>  171
<212>  PRT
<213>  Homosapiens

<400>  6932

Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val Asp Asp 
1               5                   10                  15      


Cys Gly Gly Ala Phe Thr Met Gly Thr Ile Gly Gly Gly Ile Phe Gln 
            20                  25                  30          


Ala Ile Lys Gly Phe Arg Asn Ser Pro Val Gly Val Asn His Arg Leu 
        35                  40                  45              


Arg Gly Ser Leu Thr Ala Ile Lys Thr Arg Ala Pro Gln Leu Gly Gly 
    50                  55                  60                  


Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Met Ile Asp Cys Ser Met 
65                  70                  75                  80  


Val Gln Val Arg Gly Lys Glu Asp Pro Trp Asn Ser Ile Thr Ser Gly 
                85                  90                  95      


Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg Asn Gly Pro Val Ala Met 
            100                 105                 110         


Val Gly Ser Ala Ala Met Gly Gly Ile Leu Leu Ala Leu Ile Glu Gly 
        115                 120                 125             


Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser Ala Gln Phe Pro Asn Gly 
    130                 135                 140                 


Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu Pro Ser Thr Gln Leu Pro 
145                 150                 155                 160 


Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr Gln 
                165                 170     


<210>  6933
<211>  1051
<212>  DNA
<213>  Homosapiens

<400>  6933
actcgcggca ttggagtcaa gatggaggag tacgcgcgag agccttgccc atggcgaatt     60

gtggatgact gtggtggggc ctttacgatg ggtaccattg gtggtggtat ctttcaagca    120

atcaaaggtt ttcgcaattc tccagtggga gtaaaccaca gactacgagg gagtttgaca    180

gctattaaaa ccagggctcc acagttagga gcatggattg gcttacacct gtaatacgtt    240

ccagaatagc tggatttctt ttgttttccc atcggtgatt ttcatagagt agatgctcaa    300

tgacatataa tgcagaaagg ccaaaaatag aggtagcttt gcagtttggg gagggctgtt    360

ttccatgatt gactgtagta tggttcaagt cagaggaaag gaagatccct ggaactccat    420

cacaagtggt gccttaacgg gagccatact ggcagcaaga aatggaccag tggccatggt    480

tgggtcagcc gcaatgggtg gcattctcct agctttaatt gaaggagctg gtatcttgtt    540

gacaagattt gcctctgcac agtttcccaa tggtcctcag tttgcagaag acccctccca    600

gttgccttca actcagttac cttcctcacc ttttggagac tatcgacaat atcagtagga    660

cttctttcct aggatttctt taacagaacg agttgtggtt cgagaaggat ttcagaagat    720

caagttacag tctgttttta aaaccatagg tgggacagct atggccaata ggctataaag    780

agacatttag cacttttttc tatttaaagg aacaagcggg gaagggtgct aaaagataat    840

acgtttattt attcacactt gaattgcatt tgtgatcaaa ataaatgttt aaatcgctaa    900

aggaaaatac agtaagtgct tgaaagatga aggaccaaaa ggccaaaaaa cagtgaaata    960

tgatcatcat ctccttgcgg acttctctgc ctggttttgt gtgttctgtt attcaaacaa   1020

taaaaagctg gtggaactta ctctttcttt t                                  1051


<210>  6934
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  6934

Met Ile Asp Cys Ser Met Val Gln Val Arg Gly Lys Glu Asp Pro Trp 
1               5                   10                  15      


Asn Ser Ile Thr Ser Gly Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg 
            20                  25                  30          


Asn Gly Pro Val Ala Met Val Gly Ser Ala Ala Met Gly Gly Ile Leu 
        35                  40                  45              


Leu Ala Leu Ile Glu Gly Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser 
    50                  55                  60                  


Ala Gln Phe Pro Asn Gly Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu 
65                  70                  75                  80  


Pro Ser Thr Gln Leu Pro Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr 
                85                  90                  95      


Gln 
    


<210>  6935
<211>  1458
<212>  DNA
<213>  Homosapiens

<400>  6935
actcgcggca ttggagtcaa gatggaggag tacgcgcgag agccttgccc atggcgaatt     60

gtggatgact gtggtggggc ctttacgatg ggtaccattg gtggtggtat ctttcaagca    120

atcaaaggtt ttcgcaattc tccagtggga gtaaaccaca gactacgagg gagtttgaca    180

gctattaaaa ccagggctcc acagttagga gcatggattg gcttacacct gtaatacgtt    240

ccagaatagc tggatttctt ttgttttccc atcggtgatt ttcatagagt agatgctcaa    300

tgacatataa tgcagaaagg ccaaaaatag aggtagcttt gcagtttggg gagggctgtt    360

ttccatgatt gactgtagta tggttcaagt cagaggaaag gaagatccct ggaactccat    420

cacaagtggt gccttaacgg gagccatact ggcagcaaga aatggaccag tggccatggt    480

tgggtcagcc gcaatgggtg gcattctcct agctttaatt gaaggagctg gtatcttgtt    540

gacaagattt gcctctgcac agtttcccaa tggtcctcag tttgcagaag acccctccca    600

gttgccttca actcagttac cttcctcacc ttttggagac tatcgacaat atcagtagga    660

cttctttcct aggatttctt taacagaacg agttgtggtt cgagaaggat ttcagaagat    720

caagttacag tctgttttta aaaccatagg tgggacagct atggccaata ggctataaag    780

agacatttag cacttttttc tatttaaagg aacaagcggg gaagggtgct aaaagataat    840

acgtttattt attcacactt gaattgcatt tgtgatcaaa ataaatgttt aaatcgctaa    900

aggaaaatac agtaagtgct tgaaagatga aggaccaaaa ggccaaaaaa cagtgaaata    960

tgatcatcat ctccttgcgg acttctctgc ctggttttgt gtgttctgtt attcaaacaa   1020

taaaaagctg gtggaactta ctctttcttt taagataagt tgtagacttc gatgtttcat   1080

gctcatgtac ttcaaataat gcatgtttta tagttagtcc ctcatcactt gaagtgactt   1140

ctgagaatta tgcagagtca acatggatca tttcacagtg agatgcttta tggattgaag   1200

gatatggtaa aatgtttata gtttactttg aaagtaaaat atactatgtc ttggttttga   1260

ggatattgga tacaaaactc tcttccttta gggctactga gtcttgattc ctgatcatca   1320

gaaatttcac cagaaacaac ttgcttccaa tatacccaat tctatatgaa gaattcatgg   1380

agagtgtact ggcactggaa gagtttagtg tttcttgtat gcttgaaaat aaagtatgta   1440

ctgttttgaa tgtgttcc                                                 1458


<210>  6936
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  6936

Met Ile Asp Cys Ser Met Val Gln Val Arg Gly Lys Glu Asp Pro Trp 
1               5                   10                  15      


Asn Ser Ile Thr Ser Gly Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg 
            20                  25                  30          


Asn Gly Pro Val Ala Met Val Gly Ser Ala Ala Met Gly Gly Ile Leu 
        35                  40                  45              


Leu Ala Leu Ile Glu Gly Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser 
    50                  55                  60                  


Ala Gln Phe Pro Asn Gly Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu 
65                  70                  75                  80  


Pro Ser Thr Gln Leu Pro Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr 
                85                  90                  95      


Gln 
    


<210>  6937
<211>  1764
<212>  DNA
<213>  Homosapiens

<400>  6937
actcgcggca ttggagtcaa gatggaggag tacgcgcgag agccttgccc atggcgaatt     60

gtggatgact gtggtggggc ctttacgatg ggtaccattg gtggtggtat ctttcaagca    120

atcaaaggtt ttcgcaattc tccagtggga gtaaaccaca gactacgagg gagtttgaca    180

gctattaaaa ccagggctcc acagttagga gcatggattg gcttacacct gtaatacgtt    240

ccagaatagc tggatttctt ttgttttccc atcggtgatt ttcatagagt agatgctcaa    300

tgacatataa tgcagaaagg ccaaaaatag aggtagcttt gcagtttggg gagggctgtt    360

ttccatgatt gactgtagta tggttcaagt cagaggaaag gaagatccct ggaactccat    420

cacaagtggt gccttaacgg gagccatact ggcagcaaga aatggaccag tggccatggt    480

tgggtcagcc gcaatgggtg gcattctcct agctttaatt gaaggagctg gtatcttgtt    540

gacaagattt gcctctgcac agtttcccaa tggtcctcag tttgcagaag acccctccca    600

gttgccttca actcagttac cttcctcacc ttttggagac tatcgacaat atcagtagga    660

cttctttcct aggatttctt taacagaacg agttgtggtt cgagaaggat ttcagaagat    720

caagttacag tctgttttta aaaccatagg tgggacagct atggccaata ggctataaag    780

agacatttag cacttttttc tatttaaagg aacaagcggg gaagggtgct aaaagataat    840

acgtttattt attcacactt gaattgcatt tgtgatcaaa ataaatgttt aaatcgctaa    900

aggaaaatac agtaagtgct tgaaagatga aggaccaaaa ggccaaaaaa cagtgaaata    960

tgatcatcat ctccttgcgg acttctctgc ctggttttgt gtgttctgtt attcaaacaa   1020

taaaaagctg gtggaactta ctctttcttt taagataagt tgtagacttc gatgtttcat   1080

gctcatgtac ttcaaataat gcatgtttta tagttagtcc ctcatcactt gaagtgactt   1140

ctgagaatta tgcagagtca acatggatca tttcacagtg agatgcttta tggattgaag   1200

gatatggtaa aatgtttata gtttactttg aaagtaaaat atactatgtc ttggttttga   1260

ggatattgga tacaaaactc tcttccttta gggctactga gtcttgattc ctgatcatca   1320

gaaatttcac cagaaacaac ttgcttccaa tatacccaat tctatatgaa gaattcatgg   1380

agagtgtact ggcactggaa gagtttagtg tttcttgtat gcttgaaaat aaagtatgta   1440

ctgttttgaa tgtgttccaa gtcctctgca taaacgatgt attttggggt ctggttgggc   1500

ctggaaaatg gatgagcact tcagaacagg tcattttcct gatattggaa gtgacatgtg   1560

gccctatagg aggcatgatg ttagttaatt acacatttgc ctacatctgt gggaaatgga   1620

gaacaaagcc atgtgggtac tgtaaacaca cgtttatctt ttggcccaat gccatacata   1680

tggtaggcat ttaattactg attgtgtttg gataatttgg gaattttcga ctgtggtaaa   1740

atatacataa aataatactt atta                                          1764


<210>  6938
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  6938

Met Ile Asp Cys Ser Met Val Gln Val Arg Gly Lys Glu Asp Pro Trp 
1               5                   10                  15      


Asn Ser Ile Thr Ser Gly Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg 
            20                  25                  30          


Asn Gly Pro Val Ala Met Val Gly Ser Ala Ala Met Gly Gly Ile Leu 
        35                  40                  45              


Leu Ala Leu Ile Glu Gly Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser 
    50                  55                  60                  


Ala Gln Phe Pro Asn Gly Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu 
65                  70                  75                  80  


Pro Ser Thr Gln Leu Pro Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr 
                85                  90                  95      


Gln 
    


<210>  6939
<211>  746
<212>  DNA
<213>  Homosapiens

<400>  6939
gcggcattgg agtcaagatg gaggagtacg cgcgagagcc ttgcccatgg cgaattgtgg     60

atgactgtgg tggggccttt acgatgggta ccattggtgg tggtatcttt caagcaatca    120

aaggttttcg caattctcca gtgggagtaa accacagact acgagggagt ttgacagcta    180

ttaaaaccag ggctccacag ttaggaggta agcagaattt tcattttaac tgaactattt    240

ttttctgttc ctttgaagat ggagctattt ttatttttag attacaacaa ttagtgattt    300

tagtttggtc taacggtttg tcacaaacat atatccctat agtttcttct tgatttgtag    360

tttgtttgaa aaattaacct gaattatgat acccatttga aaatcttgtc tctgtccttc    420

agacactcgg tgattttttt tttttttcct tctccagaag aaagacagtt atttaaagct    480

caggtgtgag gccgggcacg gggctcacgc ctgtaatccc agcactttgg gaggccgagg    540

tgggcagatc acctgaggtc aggagtttga gaccagcctg accaacatgg agaaacccca    600

tctctactaa aaatacaaaa ttagctgggc gtggtggcgc atgcctgtaa tcccagctac    660

tcaggagact gaggcaggag aatcacttga acccgggagg cggaggttgc agtgagccaa    720

gatcatgcca ttgcactcca tcctgg                                         746


<210>  6940
<211>  71
<212>  PRT
<213>  Homosapiens

<400>  6940

Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val Asp Asp 
1               5                   10                  15      


Cys Gly Gly Ala Phe Thr Met Gly Thr Ile Gly Gly Gly Ile Phe Gln 
            20                  25                  30          


Ala Ile Lys Gly Phe Arg Asn Ser Pro Val Gly Val Asn His Arg Leu 
        35                  40                  45              


Arg Gly Ser Leu Thr Ala Ile Lys Thr Arg Ala Pro Gln Leu Gly Gly 
    50                  55                  60                  


Lys Gln Asn Phe His Phe Asn 
65                  70      


<210>  6941
<211>  996
<212>  DNA
<213>  Homosapiens

<400>  6941
gcggcattgg agtcaagatg gaggagtacg cgcgagagcc ttgcccatgg cgaattgtgg     60

atgactgtgg tggggccttt acgatgggta ccattggtgg tggtatcttt caagcaatca    120

aaggttttcg caattctcca gtgggagtaa accacagact acgagggagt ttgacagcta    180

ttaaaaccag ggctccacag ttaggagtaa tgaagaagtt agtactatta ttatctccca    240

ttttccagat gaggaaattt agttcctgag ggttgaggta gctttgcagt ttggggaggg    300

ctgttttcca tgattgactg tagtatggtt caagtcagag gaaaggaaga tccctggaac    360

tccatcacaa gtggtgcctt aacgggagcc atactggcag caagaaatgg accagtggcc    420

atggttgggt cagccgcaat gggtggcatt ctcctagctt taattgaagg agctggtatc    480

ttgttgacaa gatttgcctc tgcacagttt cccaatggtc ctcagtttgc agaagacccc    540

tcccagttgc cttcaactca gttaccttcc tcaccttttg gagactatcg acaatatcag    600

taggacttct ttcctaggat ttctttaaca gaacgagttg tggttcgaga aggatttcag    660

aagatcaagt tacagtctgt ttttaaaacc ataggtggga cagctatggc caataggcta    720

taaagagaca tttagcactt ttttctattt aaaggaacaa gcggggaagg gtgctaaaag    780

ataatacgtt tatttattca cacttgaatt gcatttgtga tcaaaataaa tgtttaaatc    840

gctaaaggaa aatacagtaa gtgcttgaaa gatgaaggac caaaaggcca aaaaacagtg    900

aaatatgatc atcatctcct tgcggacttc tctgcctggt tttgtgtgtt ctgttattca    960

aacaataaaa agctggtgga acttactctt tctttt                              996


<210>  6942
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  6942

Met Ile Asp Cys Ser Met Val Gln Val Arg Gly Lys Glu Asp Pro Trp 
1               5                   10                  15      


Asn Ser Ile Thr Ser Gly Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg 
            20                  25                  30          


Asn Gly Pro Val Ala Met Val Gly Ser Ala Ala Met Gly Gly Ile Leu 
        35                  40                  45              


Leu Ala Leu Ile Glu Gly Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser 
    50                  55                  60                  


Ala Gln Phe Pro Asn Gly Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu 
65                  70                  75                  80  


Pro Ser Thr Gln Leu Pro Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr 
                85                  90                  95      


Gln 
    


<210>  6943
<211>  1403
<212>  DNA
<213>  Homosapiens

<400>  6943
gcggcattgg agtcaagatg gaggagtacg cgcgagagcc ttgcccatgg cgaattgtgg     60

atgactgtgg tggggccttt acgatgggta ccattggtgg tggtatcttt caagcaatca    120

aaggttttcg caattctcca gtgggagtaa accacagact acgagggagt ttgacagcta    180

ttaaaaccag ggctccacag ttaggagtaa tgaagaagtt agtactatta ttatctccca    240

ttttccagat gaggaaattt agttcctgag ggttgaggta gctttgcagt ttggggaggg    300

ctgttttcca tgattgactg tagtatggtt caagtcagag gaaaggaaga tccctggaac    360

tccatcacaa gtggtgcctt aacgggagcc atactggcag caagaaatgg accagtggcc    420

atggttgggt cagccgcaat gggtggcatt ctcctagctt taattgaagg agctggtatc    480

ttgttgacaa gatttgcctc tgcacagttt cccaatggtc ctcagtttgc agaagacccc    540

tcccagttgc cttcaactca gttaccttcc tcaccttttg gagactatcg acaatatcag    600

taggacttct ttcctaggat ttctttaaca gaacgagttg tggttcgaga aggatttcag    660

aagatcaagt tacagtctgt ttttaaaacc ataggtggga cagctatggc caataggcta    720

taaagagaca tttagcactt ttttctattt aaaggaacaa gcggggaagg gtgctaaaag    780

ataatacgtt tatttattca cacttgaatt gcatttgtga tcaaaataaa tgtttaaatc    840

gctaaaggaa aatacagtaa gtgcttgaaa gatgaaggac caaaaggcca aaaaacagtg    900

aaatatgatc atcatctcct tgcggacttc tctgcctggt tttgtgtgtt ctgttattca    960

aacaataaaa agctggtgga acttactctt tcttttaaga taagttgtag acttcgatgt   1020

ttcatgctca tgtacttcaa ataatgcatg ttttatagtt agtccctcat cacttgaagt   1080

gacttctgag aattatgcag agtcaacatg gatcatttca cagtgagatg ctttatggat   1140

tgaaggatat ggtaaaatgt ttatagttta ctttgaaagt aaaatatact atgtcttggt   1200

tttgaggata ttggatacaa aactctcttc ctttagggct actgagtctt gattcctgat   1260

catcagaaat ttcaccagaa acaacttgct tccaatatac ccaattctat atgaagaatt   1320

catggagagt gtactggcac tggaagagtt tagtgtttct tgtatgcttg aaaataaagt   1380

atgtactgtt ttgaatgtgt tcc                                           1403


<210>  6944
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  6944

Met Ile Asp Cys Ser Met Val Gln Val Arg Gly Lys Glu Asp Pro Trp 
1               5                   10                  15      


Asn Ser Ile Thr Ser Gly Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg 
            20                  25                  30          


Asn Gly Pro Val Ala Met Val Gly Ser Ala Ala Met Gly Gly Ile Leu 
        35                  40                  45              


Leu Ala Leu Ile Glu Gly Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser 
    50                  55                  60                  


Ala Gln Phe Pro Asn Gly Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu 
65                  70                  75                  80  


Pro Ser Thr Gln Leu Pro Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr 
                85                  90                  95      


Gln 
    


<210>  6945
<211>  1709
<212>  DNA
<213>  Homosapiens

<400>  6945
gcggcattgg agtcaagatg gaggagtacg cgcgagagcc ttgcccatgg cgaattgtgg     60

atgactgtgg tggggccttt acgatgggta ccattggtgg tggtatcttt caagcaatca    120

aaggttttcg caattctcca gtgggagtaa accacagact acgagggagt ttgacagcta    180

ttaaaaccag ggctccacag ttaggagtaa tgaagaagtt agtactatta ttatctccca    240

ttttccagat gaggaaattt agttcctgag ggttgaggta gctttgcagt ttggggaggg    300

ctgttttcca tgattgactg tagtatggtt caagtcagag gaaaggaaga tccctggaac    360

tccatcacaa gtggtgcctt aacgggagcc atactggcag caagaaatgg accagtggcc    420

atggttgggt cagccgcaat gggtggcatt ctcctagctt taattgaagg agctggtatc    480

ttgttgacaa gatttgcctc tgcacagttt cccaatggtc ctcagtttgc agaagacccc    540

tcccagttgc cttcaactca gttaccttcc tcaccttttg gagactatcg acaatatcag    600

taggacttct ttcctaggat ttctttaaca gaacgagttg tggttcgaga aggatttcag    660

aagatcaagt tacagtctgt ttttaaaacc ataggtggga cagctatggc caataggcta    720

taaagagaca tttagcactt ttttctattt aaaggaacaa gcggggaagg gtgctaaaag    780

ataatacgtt tatttattca cacttgaatt gcatttgtga tcaaaataaa tgtttaaatc    840

gctaaaggaa aatacagtaa gtgcttgaaa gatgaaggac caaaaggcca aaaaacagtg    900

aaatatgatc atcatctcct tgcggacttc tctgcctggt tttgtgtgtt ctgttattca    960

aacaataaaa agctggtgga acttactctt tcttttaaga taagttgtag acttcgatgt   1020

ttcatgctca tgtacttcaa ataatgcatg ttttatagtt agtccctcat cacttgaagt   1080

gacttctgag aattatgcag agtcaacatg gatcatttca cagtgagatg ctttatggat   1140

tgaaggatat ggtaaaatgt ttatagttta ctttgaaagt aaaatatact atgtcttggt   1200

tttgaggata ttggatacaa aactctcttc ctttagggct actgagtctt gattcctgat   1260

catcagaaat ttcaccagaa acaacttgct tccaatatac ccaattctat atgaagaatt   1320

catggagagt gtactggcac tggaagagtt tagtgtttct tgtatgcttg aaaataaagt   1380

atgtactgtt ttgaatgtgt tccaagtcct ctgcataaac gatgtatttt ggggtctggt   1440

tgggcctgga aaatggatga gcacttcaga acaggtcatt ttcctgatat tggaagtgac   1500

atgtggccct ataggaggca tgatgttagt taattacaca tttgcctaca tctgtgggaa   1560

atggagaaca aagccatgtg ggtactgtaa acacacgttt atcttttggc ccaatgccat   1620

acatatggta ggcatttaat tactgattgt gtttggataa tttgggaatt ttcgactgtg   1680

gtaaaatata cataaaataa tacttatta                                     1709


<210>  6946
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  6946

Met Ile Asp Cys Ser Met Val Gln Val Arg Gly Lys Glu Asp Pro Trp 
1               5                   10                  15      


Asn Ser Ile Thr Ser Gly Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg 
            20                  25                  30          


Asn Gly Pro Val Ala Met Val Gly Ser Ala Ala Met Gly Gly Ile Leu 
        35                  40                  45              


Leu Ala Leu Ile Glu Gly Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser 
    50                  55                  60                  


Ala Gln Phe Pro Asn Gly Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu 
65                  70                  75                  80  


Pro Ser Thr Gln Leu Pro Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr 
                85                  90                  95      


Gln 
    


<210>  6947
<211>  707
<212>  DNA
<213>  Homosapiens

<400>  6947
gttcgtgagt caggaccgat agcttctgag gtaacataaa gctgaagaga atgtgatctg     60

aaggattggg gtttcatgca ggagaaaccc atcaagccga ttgggctctt ctccaaggtt    120

ggttttggga cattgtgcag aggtcattgg aaaatttgaa aagattctat tcattgtact    180

ttgtaaactt ggttattcag aagctgggaa aagggaggtg acaaaaaatg tttgtaggtt    240

atattcactt acaaaggtat agtcagggtt gggcgcaatg gctcacgcca ataatcccag    300

catgctggga ttacaggtgt gagctatggc acccggctgg cttatttctt ataggctttg    360

ggccgttgct aattttccag ctgatataat acaatccagc tttattcgaa agataagtat    420

tctaactctt gttcggtgtt tattcaaact tgtgtttgca tgtatttgtt tggactataa    480

attttgagac tatagtgagt atgtttttga ctataatatt ttaaatggaa gatgaaattt    540

aaattagtat ttgcttgttt ctttttacaa taaaataggt agctttgcag tttggggagg    600

gctgttttcc atgattgact gtagtatggt tcaagtcaga ggaaaggaag atccctggaa    660

ctccatcaca agtggtgcct taacgggagc catactggca gcaagaa                  707


<210>  6948
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  6948

Met Phe Val Gly Tyr Ile His Leu Gln Arg Tyr Ser Gln Gly Trp Ala 
1               5                   10                  15      


Gln Trp Leu Thr Pro Ile Ile Pro Ala Cys Trp Asp Tyr Arg Cys Glu 
            20                  25                  30          


Leu Trp His Pro Ala Gly Leu Phe Leu Ile Gly Phe Gly Pro Leu Leu 
        35                  40                  45              


Ile Phe Gln Leu Ile 
    50              


<210>  6949
<211>  2526
<212>  DNA
<213>  Homosapiens

<400>  6949
ctcccagggc atagaattac tgagttagaa gaaataactg gtttgttttt acataggatg     60

tgatgtctaa tattgtacta aaaatgagga tgcttatgct atactccact ggtactatcc    120

actggattta tttatttttt ttattttttg agacggagtc tcgctctgtc gcccaggctg    180

gagcacagtg gtgcaaactt ggctcactgc aagctctgcc tcctgggttc acaccattct    240

cctgcctcgg cctccagagt agctgggact acaggtgccc gccatcacac ctggctaatt    300

ttttttgtat tttttagtag agacgggggt ttcaccgtgt tggccaggat gccctcgatc    360

ttctgacctc atgatccacc cgcctcggcc tcccaaaatg ctgggattgt aggcgtgagc    420

taccgcacct ggctgttttt gtatttagat agagtttaag tgcaaagtaa tctgctgatt    480

taaggttgtt ttaaattcat atctgaggaa taaaggatgg acaggcaatt tccatccctt    540

tgatgttcca tagttctagc tatttatatc attcatttgc cccttcagca tggattggct    600

tacacctgta atacgttcca gaatagctgg atttcttttg ttttcccatc ggtgattttc    660

atagagtaga tgctcaatga catataatgc agaaaggcca aaaatagagg taagtaaagc    720

tatgaaagaa aagaagaacg aaagaggaag cagagtagtt tgattttgtt tattgctgct    780

taaaccagag agatatgtta ttctggaagg gtgatttgct tgtttttaca catatgcagc    840

ctgactgttt taggcttggc ttcttttttg tttgtttgag atggagtgtc gctcttgttg    900

cccaggctgg agtgcagtgg cacgatctcg gctcactgca acctccgcct cctgggttca    960

agcgattctc ctgcctcagc ctccccagta gctgggatta caggtgctcg ccaccacacc   1020

cggctaattt ttacattttt agtagaggcg gagtttcgcc atgttagcca ggctggtctt   1080

gaactcctgg cctcaggtga tccacccact tcagcctccc aaagtgctgg gattacaggt   1140

gtgagctatg gcacccggct ggcttatttc ttataggctt tgggccgttg ctaattttcc   1200

agctgatata atacaatcca gctttattcg aaagataagt attctaactc ttgttcggtg   1260

tttattcaaa cttgtgtttg catgtatttg tttggactat aaattttgag actatagtga   1320

gtatgttttt gactataata ttttaaatgg aagatgaaat ttaaattagt atttgcttgt   1380

ttctttttac aataaaatag gtagctttgc agtttgggga gggctgtttt ccatgattga   1440

ctgtagtatg gttcaagtca gaggaaagga agatccctgg aactccatca caagtggtgc   1500

cttaacggga gccatactgg cagcaagaaa tggaccagtg gccatggttg ggtcagccgc   1560

aatgggtggc attctcctag ctttaattga aggagctggt atcttgttga caagatttgc   1620

ctctgcacag tttcccaatg gtcctcagtt tgcagaagac ccctcccagt tgccttcaac   1680

tcagttacct tcctcacctt ttggagacta tcgacaatat cagtaggact tctttcctag   1740

gatttcttta acagaacgag ttgtggttcg agaaggattt cagaagatca agttacagtc   1800

tgtttttaaa accataggtg ggacagctat ggccaatagg ctataaagag acatttagca   1860

cttttttcta tttaaaggaa caagcgggga agggtgctaa aagataatac gtttatttat   1920

tcacacttga attgcatttg tgatcaaaat aaatgtttaa atcgctaaag gaaaatacag   1980

taagtgcttg aaagatgaag gaccaaaagg ccaaaaaaca gtgaaatatg atcatcatct   2040

ccttgcggac ttctctgcct ggttttgtgt gttctgttat tcaaacaata aaaagctggt   2100

ggaacttact ctttctttta agataagttg tagacttcga tgtttcatgc tcatgtactt   2160

caaataatgc atgttttata gttagtccct catcacttga agtgacttct gagaattatg   2220

cagagtcaac atggatcatt tcacagtgag atgctttatg gattgaagga tatggtaaaa   2280

tgtttatagt ttactttgaa agtaaaatat actatgtctt ggttttgagg atattggata   2340

caaaactctc ttcctttagg gctactgagt cttgattcct gatcatcaga aatttcacca   2400

gaaacaactt gcttccaata tacccaattc tatatgaaga attcatggag agtgtactgg   2460

cactggaaga gtttagtgtt tcttgtatgc ttgaaaataa agtatgtact gttttgaatg   2520

tgttcc                                                              2526


<210>  6950
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  6950

Met Ile Asp Cys Ser Met Val Gln Val Arg Gly Lys Glu Asp Pro Trp 
1               5                   10                  15      


Asn Ser Ile Thr Ser Gly Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg 
            20                  25                  30          


Asn Gly Pro Val Ala Met Val Gly Ser Ala Ala Met Gly Gly Ile Leu 
        35                  40                  45              


Leu Ala Leu Ile Glu Gly Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser 
    50                  55                  60                  


Ala Gln Phe Pro Asn Gly Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu 
65                  70                  75                  80  


Pro Ser Thr Gln Leu Pro Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr 
                85                  90                  95      


Gln 
    


<210>  6951
<211>  2832
<212>  DNA
<213>  Homosapiens

<400>  6951
ctcccagggc atagaattac tgagttagaa gaaataactg gtttgttttt acataggatg     60

tgatgtctaa tattgtacta aaaatgagga tgcttatgct atactccact ggtactatcc    120

actggattta tttatttttt ttattttttg agacggagtc tcgctctgtc gcccaggctg    180

gagcacagtg gtgcaaactt ggctcactgc aagctctgcc tcctgggttc acaccattct    240

cctgcctcgg cctccagagt agctgggact acaggtgccc gccatcacac ctggctaatt    300

ttttttgtat tttttagtag agacgggggt ttcaccgtgt tggccaggat gccctcgatc    360

ttctgacctc atgatccacc cgcctcggcc tcccaaaatg ctgggattgt aggcgtgagc    420

taccgcacct ggctgttttt gtatttagat agagtttaag tgcaaagtaa tctgctgatt    480

taaggttgtt ttaaattcat atctgaggaa taaaggatgg acaggcaatt tccatccctt    540

tgatgttcca tagttctagc tatttatatc attcatttgc cccttcagca tggattggct    600

tacacctgta atacgttcca gaatagctgg atttcttttg ttttcccatc ggtgattttc    660

atagagtaga tgctcaatga catataatgc agaaaggcca aaaatagagg taagtaaagc    720

tatgaaagaa aagaagaacg aaagaggaag cagagtagtt tgattttgtt tattgctgct    780

taaaccagag agatatgtta ttctggaagg gtgatttgct tgtttttaca catatgcagc    840

ctgactgttt taggcttggc ttcttttttg tttgtttgag atggagtgtc gctcttgttg    900

cccaggctgg agtgcagtgg cacgatctcg gctcactgca acctccgcct cctgggttca    960

agcgattctc ctgcctcagc ctccccagta gctgggatta caggtgctcg ccaccacacc   1020

cggctaattt ttacattttt agtagaggcg gagtttcgcc atgttagcca ggctggtctt   1080

gaactcctgg cctcaggtga tccacccact tcagcctccc aaagtgctgg gattacaggt   1140

gtgagctatg gcacccggct ggcttatttc ttataggctt tgggccgttg ctaattttcc   1200

agctgatata atacaatcca gctttattcg aaagataagt attctaactc ttgttcggtg   1260

tttattcaaa cttgtgtttg catgtatttg tttggactat aaattttgag actatagtga   1320

gtatgttttt gactataata ttttaaatgg aagatgaaat ttaaattagt atttgcttgt   1380

ttctttttac aataaaatag gtagctttgc agtttgggga gggctgtttt ccatgattga   1440

ctgtagtatg gttcaagtca gaggaaagga agatccctgg aactccatca caagtggtgc   1500

cttaacggga gccatactgg cagcaagaaa tggaccagtg gccatggttg ggtcagccgc   1560

aatgggtggc attctcctag ctttaattga aggagctggt atcttgttga caagatttgc   1620

ctctgcacag tttcccaatg gtcctcagtt tgcagaagac ccctcccagt tgccttcaac   1680

tcagttacct tcctcacctt ttggagacta tcgacaatat cagtaggact tctttcctag   1740

gatttcttta acagaacgag ttgtggttcg agaaggattt cagaagatca agttacagtc   1800

tgtttttaaa accataggtg ggacagctat ggccaatagg ctataaagag acatttagca   1860

cttttttcta tttaaaggaa caagcgggga agggtgctaa aagataatac gtttatttat   1920

tcacacttga attgcatttg tgatcaaaat aaatgtttaa atcgctaaag gaaaatacag   1980

taagtgcttg aaagatgaag gaccaaaagg ccaaaaaaca gtgaaatatg atcatcatct   2040

ccttgcggac ttctctgcct ggttttgtgt gttctgttat tcaaacaata aaaagctggt   2100

ggaacttact ctttctttta agataagttg tagacttcga tgtttcatgc tcatgtactt   2160

caaataatgc atgttttata gttagtccct catcacttga agtgacttct gagaattatg   2220

cagagtcaac atggatcatt tcacagtgag atgctttatg gattgaagga tatggtaaaa   2280

tgtttatagt ttactttgaa agtaaaatat actatgtctt ggttttgagg atattggata   2340

caaaactctc ttcctttagg gctactgagt cttgattcct gatcatcaga aatttcacca   2400

gaaacaactt gcttccaata tacccaattc tatatgaaga attcatggag agtgtactgg   2460

cactggaaga gtttagtgtt tcttgtatgc ttgaaaataa agtatgtact gttttgaatg   2520

tgttccaagt cctctgcata aacgatgtat tttggggtct ggttgggcct ggaaaatgga   2580

tgagcacttc agaacaggtc attttcctga tattggaagt gacatgtggc cctataggag   2640

gcatgatgtt agttaattac acatttgcct acatctgtgg gaaatggaga acaaagccat   2700

gtgggtactg taaacacacg tttatctttt ggcccaatgc catacatatg gtaggcattt   2760

aattactgat tgtgtttgga taatttggga attttcgact gtggtaaaat atacataaaa   2820

taatacttat ta                                                       2832


<210>  6952
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  6952

Met Ile Asp Cys Ser Met Val Gln Val Arg Gly Lys Glu Asp Pro Trp 
1               5                   10                  15      


Asn Ser Ile Thr Ser Gly Ala Leu Thr Gly Ala Ile Leu Ala Ala Arg 
            20                  25                  30          


Asn Gly Pro Val Ala Met Val Gly Ser Ala Ala Met Gly Gly Ile Leu 
        35                  40                  45              


Leu Ala Leu Ile Glu Gly Ala Gly Ile Leu Leu Thr Arg Phe Ala Ser 
    50                  55                  60                  


Ala Gln Phe Pro Asn Gly Pro Gln Phe Ala Glu Asp Pro Ser Gln Leu 
65                  70                  75                  80  


Pro Ser Thr Gln Leu Pro Ser Ser Pro Phe Gly Asp Tyr Arg Gln Tyr 
                85                  90                  95      


Gln 
    


<210>  6953
<211>  2431
<212>  DNA
<213>  Homosapiens

<400>  6953
gctcccctcg ggttcgcggc ccggccggtg agcaacggct ctgcggccat ggcgagcggc     60

gagcattccc ccggcagcgg cgcggcccgg cggccgctgc actccgcgca ggctgtggac    120

gtggcctcgg cctccaactt ccgggccttt gagctgctgc acttgcacct ggacctgcgg    180

gctgagttcg ggcctccagg gcccggcgca gggagccggg ggctgagcgg caccgcggtc    240

ctggacctgc gctgcctgga gcccgagggc gccgccgagc tgcggctgga ctcgcacccg    300

tgcctggagg tgacggcggc ggcgctgcgg cgggagcggc ccggctcgga ggagccgcct    360

gcggagcccg tgagcttcta cacgcagccc ttctcgcact atggccaggc cctgtgcgtg    420

tccttcccgc agccctgccg cgccgccgag cgcctccagg tgctgctcac ctaccgcgtc    480

ggggagggac ccggggtttg ctggttggct cccgagcaga cagcaggaaa gaagaagccc    540

ttcgtgtaca cccagggcca ggctgtccta aaccgggcct tcttcccttg cttcgacacg    600

cctgctgtta aatacaagta ttcagctctt attgaggtcc cagatggctt cacagctgtg    660

atgagtgcta gcacctggga gaagagaggt ccaaataagt tcttcttcca gatgtgtcag    720

cccatcccct cctatctgat agctttggcc atcggagatc tggtttcggc tgaagttgga    780

cccaggagcc gggtgtgggc tgagccctgc ctgattgatg ctgccaagga ggagtacaac    840

ggggtgatag aagaattttt ggcaacagga gagaagcttt ttggacctta tgtttgggga    900

aggtatgact tgctcttcat gccaccgtcc tttccatttg gaggaatgga gaacccttgt    960

ctgacctttg tcaccccctg cctgctagct ggggaccgct ccttggcaga tgtcatcatc   1020

catgagatct cccacagttg gtttgggaac ctggtcacca acgccaactg gggtgaattc   1080

tggctcaatg aaggtttcac catgtacgcc cagaggagga tctccaccat cctctttggc   1140

gctgcgtaca cctgcttgga ggctgcaacg gggcgggctc tgctgcgtca gcacatggac   1200

atcactggag aggaaaaccc actcaacaag ctccgcgtga agattgaacc aggcgttgac   1260

ccggacgaca cctataatga gaccccctac gagaaaggtt tctgctttgt ttcatacctg   1320

gcccacttgg tgggtgatca ggatcagttt gacagttttc tcaaggccta tgtgcatgaa   1380

ttcaaattcc gaagcatctt agccgatgac tttctggact tctacttgga atatttccct   1440

gagcttaaga aaaagagagt ggatatcatt ccaggttttg agtttgatcg atggctgaat   1500

acccccggct ggcccccgta cctccctgat ctctcccctg gggactcact catgaagcct   1560

gctgaagagc tagcccaact gtgggcagcc gaggagctgg acatgaaggc cattgaagcc   1620

gtggccatct ctccctggaa gacctaccag ctggtctact tcctggataa gatcctccag   1680

aaatcccctc tccctcctgg gaatgtgaaa aaacttggag acacataccc aagtatctca   1740

aatgcccgga atgcagagct ccggctgcga tggggccaaa tcgtccttaa gaacgaccac   1800

caggaagatt tctggaaagt gaaggagttc ctgcataacc aggggaagca gaagtataca   1860

cttccgctgt accacgcaat gatgggtggc agtgaggtgg cccagaccct cgccaaggag   1920

acttttgcat ccaccgcctc ccagctccac agcaatgttg tcaactatgt ccagcagatc   1980

gtggcaccca agggcagtta gaggctcgtg tgcatggccc ctgcctcttc aggctctcca   2040

ggctttcaga ataattgttt gttcccaaat tcctgttccc tgatcaactt cctggagttt   2100

atatcccctc aggataatct attctctagc ttaggtatct gtgactcttg ggcctctgct   2160

ctggtgggaa cttacttctc tatagcccac tgagccccga gacagagaac ctgcccacag   2220

ctctccccgc tacaggctgc aggcactgca gggcagcggg tattctcctc cccacctaag   2280

tctctgggaa gaagtggaga ggactgatgc tcttcttttt tctctttctg tcctttttct   2340

tgctgatttt atgcaaaggg ctggcattct gattgttctt ttttcaggtt taatccttat   2400

tttaataaag ttttcaagca aaaattaagt t                                  2431


<210>  6954
<211>  650
<212>  PRT
<213>  Homosapiens

<400>  6954

Met Ala Ser Gly Glu His Ser Pro Gly Ser Gly Ala Ala Arg Arg Pro 
1               5                   10                  15      


Leu His Ser Ala Gln Ala Val Asp Val Ala Ser Ala Ser Asn Phe Arg 
            20                  25                  30          


Ala Phe Glu Leu Leu His Leu His Leu Asp Leu Arg Ala Glu Phe Gly 
        35                  40                  45              


Pro Pro Gly Pro Gly Ala Gly Ser Arg Gly Leu Ser Gly Thr Ala Val 
    50                  55                  60                  


Leu Asp Leu Arg Cys Leu Glu Pro Glu Gly Ala Ala Glu Leu Arg Leu 
65                  70                  75                  80  


Asp Ser His Pro Cys Leu Glu Val Thr Ala Ala Ala Leu Arg Arg Glu 
                85                  90                  95      


Arg Pro Gly Ser Glu Glu Pro Pro Ala Glu Pro Val Ser Phe Tyr Thr 
            100                 105                 110         


Gln Pro Phe Ser His Tyr Gly Gln Ala Leu Cys Val Ser Phe Pro Gln 
        115                 120                 125             


Pro Cys Arg Ala Ala Glu Arg Leu Gln Val Leu Leu Thr Tyr Arg Val 
    130                 135                 140                 


Gly Glu Gly Pro Gly Val Cys Trp Leu Ala Pro Glu Gln Thr Ala Gly 
145                 150                 155                 160 


Lys Lys Lys Pro Phe Val Tyr Thr Gln Gly Gln Ala Val Leu Asn Arg 
                165                 170                 175     


Ala Phe Phe Pro Cys Phe Asp Thr Pro Ala Val Lys Tyr Lys Tyr Ser 
            180                 185                 190         


Ala Leu Ile Glu Val Pro Asp Gly Phe Thr Ala Val Met Ser Ala Ser 
        195                 200                 205             


Thr Trp Glu Lys Arg Gly Pro Asn Lys Phe Phe Phe Gln Met Cys Gln 
    210                 215                 220                 


Pro Ile Pro Ser Tyr Leu Ile Ala Leu Ala Ile Gly Asp Leu Val Ser 
225                 230                 235                 240 


Ala Glu Val Gly Pro Arg Ser Arg Val Trp Ala Glu Pro Cys Leu Ile 
                245                 250                 255     


Asp Ala Ala Lys Glu Glu Tyr Asn Gly Val Ile Glu Glu Phe Leu Ala 
            260                 265                 270         


Thr Gly Glu Lys Leu Phe Gly Pro Tyr Val Trp Gly Arg Tyr Asp Leu 
        275                 280                 285             


Leu Phe Met Pro Pro Ser Phe Pro Phe Gly Gly Met Glu Asn Pro Cys 
    290                 295                 300                 


Leu Thr Phe Val Thr Pro Cys Leu Leu Ala Gly Asp Arg Ser Leu Ala 
305                 310                 315                 320 


Asp Val Ile Ile His Glu Ile Ser His Ser Trp Phe Gly Asn Leu Val 
                325                 330                 335     


Thr Asn Ala Asn Trp Gly Glu Phe Trp Leu Asn Glu Gly Phe Thr Met 
            340                 345                 350         


Tyr Ala Gln Arg Arg Ile Ser Thr Ile Leu Phe Gly Ala Ala Tyr Thr 
        355                 360                 365             


Cys Leu Glu Ala Ala Thr Gly Arg Ala Leu Leu Arg Gln His Met Asp 
    370                 375                 380                 


Ile Thr Gly Glu Glu Asn Pro Leu Asn Lys Leu Arg Val Lys Ile Glu 
385                 390                 395                 400 


Pro Gly Val Asp Pro Asp Asp Thr Tyr Asn Glu Thr Pro Tyr Glu Lys 
                405                 410                 415     


Gly Phe Cys Phe Val Ser Tyr Leu Ala His Leu Val Gly Asp Gln Asp 
            420                 425                 430         


Gln Phe Asp Ser Phe Leu Lys Ala Tyr Val His Glu Phe Lys Phe Arg 
        435                 440                 445             


Ser Ile Leu Ala Asp Asp Phe Leu Asp Phe Tyr Leu Glu Tyr Phe Pro 
    450                 455                 460                 


Glu Leu Lys Lys Lys Arg Val Asp Ile Ile Pro Gly Phe Glu Phe Asp 
465                 470                 475                 480 


Arg Trp Leu Asn Thr Pro Gly Trp Pro Pro Tyr Leu Pro Asp Leu Ser 
                485                 490                 495     


Pro Gly Asp Ser Leu Met Lys Pro Ala Glu Glu Leu Ala Gln Leu Trp 
            500                 505                 510         


Ala Ala Glu Glu Leu Asp Met Lys Ala Ile Glu Ala Val Ala Ile Ser 
        515                 520                 525             


Pro Trp Lys Thr Tyr Gln Leu Val Tyr Phe Leu Asp Lys Ile Leu Gln 
    530                 535                 540                 


Lys Ser Pro Leu Pro Pro Gly Asn Val Lys Lys Leu Gly Asp Thr Tyr 
545                 550                 555                 560 


Pro Ser Ile Ser Asn Ala Arg Asn Ala Glu Leu Arg Leu Arg Trp Gly 
                565                 570                 575     


Gln Ile Val Leu Lys Asn Asp His Gln Glu Asp Phe Trp Lys Val Lys 
            580                 585                 590         


Glu Phe Leu His Asn Gln Gly Lys Gln Lys Tyr Thr Leu Pro Leu Tyr 
        595                 600                 605             


His Ala Met Met Gly Gly Ser Glu Val Ala Gln Thr Leu Ala Lys Glu 
    610                 615                 620                 


Thr Phe Ala Ser Thr Ala Ser Gln Leu His Ser Asn Val Val Asn Tyr 
625                 630                 635                 640 


Val Gln Gln Ile Val Ala Pro Lys Gly Ser 
                645                 650 


<210>  6955
<211>  2326
<212>  DNA
<213>  Homosapiens

<400>  6955
aacggctctg cggccatggc gagcggcgag cattcccccg gcagcggcgc ggcccggcgg     60

ccgctgcact ccgcgcaggc tgtggacgtg gcctcggcct ccaacttccg ggcctttgag    120

ctgctgcact tgcacctgga cctgcgctgc ctggagcccg agggcgccgc cgagctgcgg    180

ctggactcgc acccgtgcct ggaggtgacg gcggcggcgc tgcggcggga gcggcccggc    240

tcggaggagc cgcctgcgga gcccgtgagc ttctacacgc agcccttctc gcactatggc    300

caggccctgt gcgtgtcctt cccgcagccc tgccgcgccg ccgagcgcct ccaggtgctg    360

ctcacctacc gcgtcgggga gggacccggg gtttgctggt tggctcccga gcagacagca    420

ggaaagaaga agcccttcgt gtacacccag ggccaggctg tcctaaaccg ggccttcttc    480

ccttgcttcg acacgcctgc tgttaaatac aagtattcag ctcttattga ggtcccagat    540

ggcttcacag ctgtgatgag tgctagcacc tgggagaaga gaggtccaaa taagttcttc    600

ttccagatgt gtcagcccat cccctcctat ctgatagctt tggccatcgg agatctggtt    660

tcggctgaag ttggacccag gagccgggtg tgggctgagc cctgcctgat tgatgctgcc    720

aaggaggagt acaacggggt gatagaagaa tttttggcaa caggagagaa gctttttgga    780

ccttatgttt ggggaaggta tgacttgctc ttcatgccac cgtcctttcc atttggagga    840

atggagaacc cttgtctgac ctttgtcacc ccctgcctgc tagctgggga ccgctccttg    900

gcagatgtca tcatccatga gatctcccac agttggtttg ggaacctggt caccaacgcc    960

aactggggtg aattctggct caatgaaggt ttcaccatgt acgcccagag gaggatctcc   1020

accatcctct ttggcgctgc gtacacctgc ttggaggctg caacggggcg ggctctgctg   1080

cgtcagcaca tggacatcac tggagaggaa aacccactca acaagctccg cgtgaagatt   1140

gaaccaggcg ttgacccgga cgacacctat aatgagaccc cctacgagaa aggtttctgc   1200

tttgtttcat acctggccca cttggtgggt gatcaggatc agtttgacag ttttctcaag   1260

gcctatgtgc atgaattcaa attccgaagc atcttagccg atgactttct ggacttctac   1320

ttggaatatt tccctgagct taagaaaaag agagtggata tcattccagg ttttgagttt   1380

gatcgatggc tgaatacccc cggctggccc ccgtacctcc ctgatctctc ccctggggac   1440

tcactcatga agcctgctga agagctagcc caactgtggg cagccgagga gctggacatg   1500

aaggccattg aagccgtggc catctctccc tggaagacct accagctggt ctacttcctg   1560

gataagatcc tccagaaatc ccctctccct cctgggaatg tgaaaaaact tggagacaca   1620

tacccaagta tctcaaatgc ccggaatgca gagctccggc tgcgatgggg ccaaatcgtc   1680

cttaagaacg accaccagga agatttctgg aaagtgaagg agttcctgca taaccagggg   1740

aagcagaagt atacacttcc gctgtaccac gcaatgatgg gtggcagtga ggtggcccag   1800

accctcgcca aggagacttt tgcatccacc gcctcccagc tccacagcaa tgttgtcaac   1860

tatgtccagc agatcgtggc acccaagggc agttagaggc tcgtgtgcat ggcccctgcc   1920

tcttcaggct ctccaggctt tcagaataat tgtttgttcc caaattcctg ttccctgatc   1980

aacttcctgg agtttatatc ccctcaggat aatctattct ctagcttagg tatctgtgac   2040

tcttgggcct ctgctctggt gggaacttac ttctctatag cccactgagc cccgagacag   2100

agaacctgcc cacagctctc cccgctacag gctgcaggca ctgcagggca gcgggtattc   2160

tcctccccac ctaagtctct gggaagaagt ggagaggact gatgctcttc ttttttctct   2220

ttctgtcctt tttcttgctg attttatgca aagggctggc attctgattg ttcttttttc   2280

aggtttaatc cttattttaa taaagttttc aagcaaaaat taagtt                  2326


<210>  6956
<211>  626
<212>  PRT
<213>  Homosapiens

<400>  6956

Met Ala Ser Gly Glu His Ser Pro Gly Ser Gly Ala Ala Arg Arg Pro 
1               5                   10                  15      


Leu His Ser Ala Gln Ala Val Asp Val Ala Ser Ala Ser Asn Phe Arg 
            20                  25                  30          


Ala Phe Glu Leu Leu His Leu His Leu Asp Leu Arg Cys Leu Glu Pro 
        35                  40                  45              


Glu Gly Ala Ala Glu Leu Arg Leu Asp Ser His Pro Cys Leu Glu Val 
    50                  55                  60                  


Thr Ala Ala Ala Leu Arg Arg Glu Arg Pro Gly Ser Glu Glu Pro Pro 
65                  70                  75                  80  


Ala Glu Pro Val Ser Phe Tyr Thr Gln Pro Phe Ser His Tyr Gly Gln 
                85                  90                  95      


Ala Leu Cys Val Ser Phe Pro Gln Pro Cys Arg Ala Ala Glu Arg Leu 
            100                 105                 110         


Gln Val Leu Leu Thr Tyr Arg Val Gly Glu Gly Pro Gly Val Cys Trp 
        115                 120                 125             


Leu Ala Pro Glu Gln Thr Ala Gly Lys Lys Lys Pro Phe Val Tyr Thr 
    130                 135                 140                 


Gln Gly Gln Ala Val Leu Asn Arg Ala Phe Phe Pro Cys Phe Asp Thr 
145                 150                 155                 160 


Pro Ala Val Lys Tyr Lys Tyr Ser Ala Leu Ile Glu Val Pro Asp Gly 
                165                 170                 175     


Phe Thr Ala Val Met Ser Ala Ser Thr Trp Glu Lys Arg Gly Pro Asn 
            180                 185                 190         


Lys Phe Phe Phe Gln Met Cys Gln Pro Ile Pro Ser Tyr Leu Ile Ala 
        195                 200                 205             


Leu Ala Ile Gly Asp Leu Val Ser Ala Glu Val Gly Pro Arg Ser Arg 
    210                 215                 220                 


Val Trp Ala Glu Pro Cys Leu Ile Asp Ala Ala Lys Glu Glu Tyr Asn 
225                 230                 235                 240 


Gly Val Ile Glu Glu Phe Leu Ala Thr Gly Glu Lys Leu Phe Gly Pro 
                245                 250                 255     


Tyr Val Trp Gly Arg Tyr Asp Leu Leu Phe Met Pro Pro Ser Phe Pro 
            260                 265                 270         


Phe Gly Gly Met Glu Asn Pro Cys Leu Thr Phe Val Thr Pro Cys Leu 
        275                 280                 285             


Leu Ala Gly Asp Arg Ser Leu Ala Asp Val Ile Ile His Glu Ile Ser 
    290                 295                 300                 


His Ser Trp Phe Gly Asn Leu Val Thr Asn Ala Asn Trp Gly Glu Phe 
305                 310                 315                 320 


Trp Leu Asn Glu Gly Phe Thr Met Tyr Ala Gln Arg Arg Ile Ser Thr 
                325                 330                 335     


Ile Leu Phe Gly Ala Ala Tyr Thr Cys Leu Glu Ala Ala Thr Gly Arg 
            340                 345                 350         


Ala Leu Leu Arg Gln His Met Asp Ile Thr Gly Glu Glu Asn Pro Leu 
        355                 360                 365             


Asn Lys Leu Arg Val Lys Ile Glu Pro Gly Val Asp Pro Asp Asp Thr 
    370                 375                 380                 


Tyr Asn Glu Thr Pro Tyr Glu Lys Gly Phe Cys Phe Val Ser Tyr Leu 
385                 390                 395                 400 


Ala His Leu Val Gly Asp Gln Asp Gln Phe Asp Ser Phe Leu Lys Ala 
                405                 410                 415     


Tyr Val His Glu Phe Lys Phe Arg Ser Ile Leu Ala Asp Asp Phe Leu 
            420                 425                 430         


Asp Phe Tyr Leu Glu Tyr Phe Pro Glu Leu Lys Lys Lys Arg Val Asp 
        435                 440                 445             


Ile Ile Pro Gly Phe Glu Phe Asp Arg Trp Leu Asn Thr Pro Gly Trp 
    450                 455                 460                 


Pro Pro Tyr Leu Pro Asp Leu Ser Pro Gly Asp Ser Leu Met Lys Pro 
465                 470                 475                 480 


Ala Glu Glu Leu Ala Gln Leu Trp Ala Ala Glu Glu Leu Asp Met Lys 
                485                 490                 495     


Ala Ile Glu Ala Val Ala Ile Ser Pro Trp Lys Thr Tyr Gln Leu Val 
            500                 505                 510         


Tyr Phe Leu Asp Lys Ile Leu Gln Lys Ser Pro Leu Pro Pro Gly Asn 
        515                 520                 525             


Val Lys Lys Leu Gly Asp Thr Tyr Pro Ser Ile Ser Asn Ala Arg Asn 
    530                 535                 540                 


Ala Glu Leu Arg Leu Arg Trp Gly Gln Ile Val Leu Lys Asn Asp His 
545                 550                 555                 560 


Gln Glu Asp Phe Trp Lys Val Lys Glu Phe Leu His Asn Gln Gly Lys 
                565                 570                 575     


Gln Lys Tyr Thr Leu Pro Leu Tyr His Ala Met Met Gly Gly Ser Glu 
            580                 585                 590         


Val Ala Gln Thr Leu Ala Lys Glu Thr Phe Ala Ser Thr Ala Ser Gln 
        595                 600                 605             


Leu His Ser Asn Val Val Asn Tyr Val Gln Gln Ile Val Ala Pro Lys 
    610                 615                 620                 


Gly Ser 
625     


<210>  6957
<211>  1477
<212>  DNA
<213>  Homosapiens

<400>  6957
gttctgtaac agtgcacctg aggctcttca tgacccgacc ctcttgggca tctcatgtcc     60

cacctcctgc cactgcctcc ctcattgcaa tctgatcctg tcctcaagta atcccagact    120

ctcggtgctt cctcacatgc atatgcagtg ttccatggct acgtctttgc ttttgatatt    180

tgggaagtac ctgatactgg tttccctgta tcttttcttc ctgttagaat agttcctatg    240

cttcagcaaa cgcagaggaa gttttccctc atccgggcct ggacccatcc cactttgcca    300

tcagtctctt tttttttttt ttttgaaaca gagtcttact ctgtcaccca ggctggagtg    360

cgatggtgca atcttggctc cccgcaacct ctgccaccca ggtgaatcac ttgagcccag    420

gagttcaaga ccagccaggg caacatagcg aaaccctacc tctacaaaaa taaaaaaatt    480

agccaggcat gatgatgtgc aactgtagtc ctagctactg gggttgggga gctgagatgg    540

aaggatcact tgagccccag gaggtggagg ttggatcaca ccactgtact ctagcctggg    600

caacagagca agaacctgtc ttaaaaaaaa aataaaaaag gtttgtctct taaggtttta    660

ttcaattcca gattctacta ttagaacgct ttcttatctc tcctctaagt agggagaaga    720

aaactaacat ttactgtata aatgtttgaa gggcttttgt gtgttgtctt atttaatctt    780

cactcatttt acagatgagg aaactgaggc tcacagaggt taaatcactt ttgcaagatc    840

gcattcagta gtgaagccat aactgcgtag cacggttcca cctccatgag gctgtcttgg    900

gttcttgttt ctcaggtgtg gtgagcggtc tcttggatct gtgtggtgat ccgatcttgc    960

actccgtcac tgtggctgac tgcattgtca cattcacttg gcggaggcca atttcctaca   1020

ggtgctttca ggatcaggtc actgcgatgg tctctaaaca ccattctgct ttctctgctc   1080

tcttgtcttt aggagccggg tgtgggctga gccctgcctg attgatgctg ccaaggagga   1140

gtacaacggg gtgatagaag aatttttggc aacaggagag aagctttttg gaccttatgt   1200

ttggggaagg tgtggtatca cattgactct agtgtctcct gttaaactga gtcactggct   1260

tccattcttc ctcttcgtgt ggcttttcca cctcctgcct cccagagcaa agtttccctg   1320

atcccagaag tgaaggagag gaggaagaga ggagggtatg agccaggctt ctcactgttg   1380

ctgaggagag ggcctaggag atgaggttct ttgtgtgtgt gtgtgtgtgt gtgtgtgtgt   1440

gtgtgtgtgt gtgttttgag atggagtctc gctctgt                            1477


<210>  6958
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  6958

Met Leu Gln Gln Thr Gln Arg Lys Phe Ser Leu Ile Arg Ala Trp Thr 
1               5                   10                  15      


His Pro Thr Leu Pro Ser Val Ser Phe Phe Phe Phe Phe Glu Thr Glu 
            20                  25                  30          


Ser Tyr Ser Val Thr Gln Ala Gly Val Arg Trp Cys Asn Leu Gly Ser 
        35                  40                  45              


Pro Gln Pro Leu Pro Pro Arg 
    50                  55  


<210>  6959
<211>  1156
<212>  DNA
<213>  Homosapiens

<400>  6959
aagagatcag aattcagctt ccccagggac agcaaggcca agaaggtgtc cagatcctgg     60

cctctctcca gatcttggac tctctcaagg ccaagactct ctctcttaag atctctatct    120

caaggccaag atctctctcc agatattggc ctctctcaag gtacttccaa gatctcagag    180

ggccattcac tgtggatcta atatgaagac agagaaacca gccttccaga ggagcggaca    240

catttcctta gtcccaggat acactttgtg tggaatccac agatctgccc tgatgatcat    300

gaaggaatgc gaaagagcct ggtaaaacga tatggacttg tgcaaatgca aagcaatggt    360

gaagtcatca cgaaccgcac agactggaca gaactcctat ctggctgcaa tggcttgggt    420

tcagtcagcc caggggccag agaattggct acaaagagct ctggagtgcc cctccctcca    480

aataaagtat tctaagcgtg cactgatcaa catgaagttc gcattaactt ggggctccaa    540

gctcaattga ggggagtggg tgtcagacag aggagcctcc tggacctggt tcaatcttca    600

cgcggagctt gttgagtggg ttttcctctc cagtgatgtc catgtgctga cgcagcagag    660

cccgccccgt tgcagcctcc aagcaggtgt acgcagcgcc tggtgcagaa tcaaacgtaa    720

gcctcgggaa aacgtctgtc accacatcca agtgtatttt cctgacagag acactgtgct    780

gcctccttgt ggcctcaaga agaacagcga cagatacctg aagcttaata acattaccct    840

cctggggacc cagggcaaat agggacagtt acagagagcc tgactcagtc cctagctccc    900

tgttgctgtg ggctacaaag gacttggtta actcaggctg ttggtctctc tcctaagtga    960

ggactggggg aatcgcacct ttctgacagt tacctttcct tatcaaagta ctgtattttt   1020

attttatctt atttcattta ttttattatt ttattttttg agacaaagcc tcactctgtc   1080

acccaggctg gagtgcaatg gcgtgatctt ggctcactgc aacctccgtc tcctcctggg   1140

ttcaagcgat tcttct                                                   1156


<210>  6960
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  6960

Met Lys Thr Glu Lys Pro Ala Phe Gln Arg Ser Gly His Ile Ser Leu 
1               5                   10                  15      


Val Pro Gly Tyr Thr Leu Cys Gly Ile His Arg Ser Ala Leu Met Ile 
            20                  25                  30          


Met Lys Glu Cys Glu Arg Ala Trp 
        35                  40  


<210>  6961
<211>  1437
<212>  DNA
<213>  Homosapiens

<400>  6961
cacggggcac tggcctgggc aggtggcggg aacgttgctg gggtgggcat ctgtgctttc     60

ggctgccctc tggcccagga aattcctccc aggggccagg ccagagatgg gccaggcagg    120

gggagggcaa gtgagggaac atgaacccct ggctgacctg agtcagaaag ctgctggccc    180

ctaaattcca gagattcagc aacaaagagg cctagtaggg agaggagtta ctaggtttag    240

gggtttttcc cagaacaccc aggactctgg ccaggggctg gaaggtgctc caggctcaat    300

gctgggcaat actcatggat taattggtgc tggctgggcc tgccagccta gtcgtggccc    360

cagggtcccc actaaagggc tccttctcca gcgcccactc tgttggcaag gtcttcacta    420

ccatcacctg cctggactcc atccaagcat cagggttgct gcagtcgctc ctgaagagac    480

ccggctctgc ttgaaagttc ttccctcagc gcctgctgga gccctccctg ccggagttgc    540

cagaatccac acggaatcca cagatctgcc ctgatgatca tgaaggaatg cgaaagagcc    600

tggtaaaacg atatggactt gtgcaaatgc aaagcaatgg tgaagtcatc acgaaccgca    660

cagactggac agaactccta tctggctgca atggcttggg ttcagtcagc ccaggggcca    720

gagaattggc tacaaagagc tctggagtgc ccctccctcc aaataaagta ttctaagcgt    780

gcactgatca acatgaagtt cgcattaact tggggctcca agctcaattg aggggagtgg    840

gtgtcagaca gaggagcctc ctggacctgg ttcaatcttc acgcggagct tgttgagtgg    900

gttttcctct ccagtgatgt ccatgtgctg acgcagcaga gcccgccccg ttgcagcctc    960

caagcaggtg tacgcagcgc ctggtgcaga atcaaacgta agcctcggga aaacgtctgt   1020

caccacatcc aagtgtattt tcctgacaga gacactgtgc tgcctccttg tggcctcaag   1080

aagaacagcg acagatacct gaagcttaat aacattaccc tcctggggac ccagggcaaa   1140

tagggacagt tacagagagc ctgactcagt ccctagctcc ctgttgctgt gggctacaaa   1200

ggacttggtt aactcaggct gttggtctct ctcctaagtg aggactgggg gaatcgcacc   1260

tttctgacag ttacctttcc ttatcaaagt actgtatttt tattttatct tatttcattt   1320

attttattat tttatttttt gagacaaagc ctcactctgt cacccaggct ggagtgcaat   1380

ggcgtgatct tggctcactg caacctccgt ctcctcctgg gttcaagcga ttcttct      1437


<210>  6962
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  6962

Met Leu Gly Asn Thr His Gly Leu Ile Gly Ala Gly Trp Ala Cys Gln 
1               5                   10                  15      


Pro Ser Arg Gly Pro Arg Val Pro Thr Lys Gly Leu Leu Leu Gln Arg 
            20                  25                  30          


Pro Leu Cys Trp Gln Gly Leu His Tyr His His Leu Pro Gly Leu His 
        35                  40                  45              


Pro Ser Ile Arg Val Ala Ala Val Ala Pro Glu Glu Thr Arg Leu Cys 
    50                  55                  60                  


Leu Lys Val Leu Pro Ser Ala Pro Ala Gly Ala Leu Pro Ala Gly Val 
65                  70                  75                  80  


Ala Arg Ile His Thr Glu Ser Thr Asp Leu Pro 
                85                  90      


<210>  6963
<211>  283
<212>  DNA
<213>  Homosapiens

<400>  6963
gtcaccagag ctcataaaag atgtgtgtgc tgtcgcatct atgtgaagta tttccatgac     60

ccgagcattg accacaggac tgtgctggag gaaactggat caaggtacca agacagatac    120

aggagggtct ccagaaaccc tagagctgaa tggaacccgt ctggaaaaca tacactggaa    180

actaggccga ggattatcca aagggtggtt gaaatcaagg gttaaagttt ggctcaagat    240

aaggaagaat cttctaataa ttaaaactga ccatccaaaa ggt                      283


<210>  6964
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  6964

Met Thr Arg Ala Leu Thr Thr Gly Leu Cys Trp Arg Lys Leu Asp Gln 
1               5                   10                  15      


Gly Thr Lys Thr Asp Thr Gly Gly Ser Pro Glu Thr Leu Glu Leu Asn 
            20                  25                  30          


Gly Thr Arg Leu Glu Asn Ile His Trp Lys Leu Gly Arg Gly Leu Ser 
        35                  40                  45              


Lys Gly Trp Leu Lys Ser Arg Val Lys Val Trp Leu Lys Ile Arg Lys 
    50                  55                  60                  


Asn Leu Leu Ile Ile Lys Thr Asp His Pro Lys 
65                  70                  75  


<210>  6965
<211>  525
<212>  DNA
<213>  Homosapiens

<400>  6965
ataatcttct gtcttaagag cacccaggat gtgttttcat tggtacggaa ttagctagcc     60

ctgggaaaga cagtccctcc agagttagca acaccccaag atgtcaaaga taaaaatgca    120

aaaattaaaa ctccatgatt aacacaactt tgaagtcctt ctcacttgtc tttagatgaa    180

gggcaacatc attgcaacaa gtcacacttt gagaactcaa gagaatatgt ttgttctgaa    240

aatccaggaa ttattgccaa cccatggttg tctccatatg tcttgggaaa aataggaaaa    300

ggattttttg agttggtgat ttgaatccaa gacacaaaga ttcaggctct ggtaaaaaga    360

ttgtataggc tatattggct gacataaaag gtaagagcaa gaatgcagag gatttctatc    420

aacataaaga agagtcaaag atggagaata agagaagtta agtggttttc ctaagatcac    480

ataattaaga cttattaata aaaagtttga tgctctttct attat                    525


<210>  6966
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  6966

Met Lys Gly Asn Ile Ile Ala Thr Ser His Thr Leu Arg Thr Gln Glu 
1               5                   10                  15      


Asn Met Phe Val Leu Lys Ile Gln Glu Leu Leu Pro Thr His Gly Cys 
            20                  25                  30          


Leu His Met Ser Trp Glu Lys 
        35                  


<210>  6967
<211>  1924
<212>  DNA
<213>  Homosapiens

<400>  6967
ggcggaggtg gggttagctt cagttgacca accatgcctt gaggataaat tggatgggat     60

cagatgggaa gatgtgacaa gaagagaaat cctcctctat ataggatgct ctgctgtttc    120

ctaaggattt tcagcacctt gccccaaaat caaaatgatg cttcaacacc caggccaggt    180

ctctgcctcg gaagtgagtg cttctgccat cgtcccctgc ctgtcccctc ctgggtcact    240

ggtgtttgag gattttgcta acctgacgcc ctttgtcaag gaagagctga ggtttgccat    300

ccagaacaag cacctctgcc accggatgtc ctctgcgctg gaatcagtca ctgtcagcga    360

cagacccctc ggggtgtcca tcacaaaagc cgaggtagcc cctgaagaag atgaaaggaa    420

aaagaggcga cgagaaagaa ataagattgc agctgcaaag tgccgaaaca agaagaagga    480

gaagacggag tgcctgcaga aagagtcgga gaagctggaa agtgtgaatg ctgaactgaa    540

ggctcagatt gaggagctca agaacgagaa gcagcatttg atatacatgc tcaaccttca    600

tcggcccacg tgtattgtcc gggctcagaa tgggaggact ccagaagatg agagaaacct    660

ctttatccaa cagataaaag aaggaacatt gcagagctaa gcagtcgtgg tatgggggcg    720

actggggagt cctcattgaa tcctcatttt atacccaaaa ccctgaagcc attggagagc    780

tgtcttcctg tgtacctcta gaatcccagc agcagagaac catcaaggcg ggagggcctg    840

cagtgattca gcaggccctt cccattctgc cccagagtgg gtcttggacc agggcaagtg    900

catctttgcc tcaactccag gatttaggcc ttaacacact ggccattctt atgttccaga    960

tggcccccag ctggtgtcct gcccgccttt catctggatt ctacaaaaaa ccaggatgcc   1020

caccgttagg attcaggcag cagtgtctgt acctcgggtg ggagggatgg ggccatctcc   1080

ttcaccgtgg ctaccattgt cactcgtagg ggatgtggag tgagaacagc atttagtgaa   1140

gttgtgcaac ggccagggtt gtgctttcta gcaaatatgc tgttatgtcc agaaattgtg   1200

tgtgcaagaa aactaggcaa tgtactcttc cgatgtttgt gtcacacaac actgatgtga   1260

cttttatatg ctttttctca gatctggttt ctaagagttt tggggggcgg ggctgtcacc   1320

acgtgcagta tctcaagata ttcaggtggc cagaagagct tgtcagcaag aggaggacag   1380

aattctccca gcgttaacac aaaatccatg ggcagtatga tggcaggtcc tctgttgcaa   1440

actcagttcc aaagtcacag gaagaaagca gaaagttcaa cttccaaagg gttaggactc   1500

tccactcaat gtcttaggtc aggagttgtg tctaggctgg aagagccaaa gaatattcca   1560

ttttcctttc cttgtggttg aaaaccacag tcagtggaga gatgtttgga aaccacagtc   1620

agtggagcct gggtggtacc caggctttag cattattgga tgtcaatagc attgtttttg   1680

tcatgtagct gttttaagaa atctggccca gggtgtttgc agctgtgaga agtcactcac   1740

actggccaca aggacgctgg ctactgtcta ttaaaattct gatgtttctg tgaaattctc   1800

agagtgttta attgtactca atggtatcat tacaattttc tgtaagagaa aatattactt   1860

atttatccta gtattcctaa cctgtcagaa taataaatat tggaaccaag acatggtaaa   1920

catg                                                                1924


<210>  6968
<211>  181
<212>  PRT
<213>  Homosapiens

<400>  6968

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Glu Ser Glu Lys Leu Glu Ser Val Asn Ala Glu Leu 
        115                 120                 125             


Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln His Leu Ile Tyr 
    130                 135                 140                 


Met Leu Asn Leu His Arg Pro Thr Cys Ile Val Arg Ala Gln Asn Gly 
145                 150                 155                 160 


Arg Thr Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln Gln Ile Lys Glu 
                165                 170                 175     


Gly Thr Leu Gln Ser 
            180     


<210>  6969
<211>  2077
<212>  DNA
<213>  Homosapiens

<400>  6969
tccgctccgt tcggccggtt ctcccgggaa gctattaata gcattacgtc agcctgggac     60

tggcaacacg gagtaaacga ccgcgccgcc agcctgaggg ctataaaagg ggtgatgcaa    120

cgctctccaa gccacagtcg cacgcagcca ggcgcgcact gcacagctct cttctctcgc    180

cgccgcccga gcgcaccctt cagcccgcgc gccggccgtg agtcctcggt gctcgcccgc    240

cggccagaca aacagcccgc ccgaccccgt cccgaccctg gccgccccga gcggagcctg    300

gagcaaaatg atgcttcaac acccaggcca ggtctctgcc tcggaagtga gtgcttctgc    360

catcgtcccc tgcctgtccc ctcctgggtc actggtgttt gaggattttg ctaacctgac    420

gccctttgtc aaggaagagc tgaggtttgc catccagaac aagcacctct gccaccggat    480

gtcctctgcg ctggaatcag tcactgtcag cgacagaccc ctcggggtgt ccatcacaaa    540

agccgaggta gcccctgaag aagatgaaag gaaaaagagg cgacgagaaa gaaataagat    600

tgcagctgca aagtgccgaa acaagaagaa ggagaagacg gagtgcctgc agaaagagtc    660

ggagaagctg gaaagtgtga atgctgaact gaaggctcag attgaggagc tcaagaacga    720

gaagcagcat ttgatataca tgctcaacct tcatcggccc acgtgtattg tccgggctca    780

gaatgggagg actccagaag atgagagaaa cctctttatc caacagataa aagaaggaac    840

attgcagagc taagcagtcg tggtatgggg gcgactgggg agtcctcatt gaatcctcat    900

tttataccca aaaccctgaa gccattggag agctgtcttc ctgtgtacct ctagaatccc    960

agcagcagag aaccatcaag gcgggagggc ctgcagtgat tcagcaggcc cttcccattc   1020

tgccccagag tgggtcttgg accagggcaa gtgcatcttt gcctcaactc caggatttag   1080

gccttaacac actggccatt cttatgttcc agatggcccc cagctggtgt cctgcccgcc   1140

tttcatctgg attctacaaa aaaccaggat gcccaccgtt aggattcagg cagcagtgtc   1200

tgtacctcgg gtgggaggga tggggccatc tccttcaccg tggctaccat tgtcactcgt   1260

aggggatgtg gagtgagaac agcatttagt gaagttgtgc aacggccagg gttgtgcttt   1320

ctagcaaata tgctgttatg tccagaaatt gtgtgtgcaa gaaaactagg caatgtactc   1380

ttccgatgtt tgtgtcacac aacactgatg tgacttttat atgctttttc tcagatctgg   1440

tttctaagag ttttgggggg cggggctgtc accacgtgca gtatctcaag atattcaggt   1500

ggccagaaga gcttgtcagc aagaggagga cagaattctc ccagcgttaa cacaaaatcc   1560

atgggcagta tgatggcagg tcctctgttg caaactcagt tccaaagtca caggaagaaa   1620

gcagaaagtt caacttccaa agggttagga ctctccactc aatgtcttag gtcaggagtt   1680

gtgtctaggc tggaagagcc aaagaatatt ccattttcct ttccttgtgg ttgaaaacca   1740

cagtcagtgg agagatgttt ggaaaccaca gtcagtggag cctgggtggt acccaggctt   1800

tagcattatt ggatgtcaat agcattgttt ttgtcatgta gctgttttaa gaaatctggc   1860

ccagggtgtt tgcagctgtg agaagtcact cacactggcc acaaggacgc tggctactgt   1920

ctattaaaat tctgatgttt ctgtgaaatt ctcagagtgt ttaattgtac tcaatggtat   1980

cattacaatt ttctgtaaga gaaaatatta cttatttatc ctagtattcc taacctgtca   2040

gaataataaa tattggaacc aagacatggt aaacatg                            2077


<210>  6970
<211>  181
<212>  PRT
<213>  Homosapiens

<400>  6970

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Glu Ser Glu Lys Leu Glu Ser Val Asn Ala Glu Leu 
        115                 120                 125             


Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln His Leu Ile Tyr 
    130                 135                 140                 


Met Leu Asn Leu His Arg Pro Thr Cys Ile Val Arg Ala Gln Asn Gly 
145                 150                 155                 160 


Arg Thr Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln Gln Ile Lys Glu 
                165                 170                 175     


Gly Thr Leu Gln Ser 
            180     


<210>  6971
<211>  1651
<212>  DNA
<213>  Homosapiens

<400>  6971
cgggaagcta ttaatagcat tacgtcagcc tgggactggc aacacggagt aaacgaccgc     60

gccgccagcc tgagggctat aaaaggggtg atgcaacgct ctccaagcca cagtcgcacg    120

cagccaggcg cgcactgcac agctctcttc tctcgccgcc gcccgagcgc acccttcagc    180

ccgcgcgccg gccgtgagtc ctcggtgctc gcccgccggc cagacaaaca gcccgcccga    240

ccccgtcccg accctggccg ccccgagcgg agcctggagc aaaatgatgc ttcaacaccc    300

aggccaggtc tctgcctcgg aagtgagtgc ttctgccatc gtcccctgcc tgtcccctcc    360

tgggtcactg gtgtttgagg attttgctaa cctgacgccc tttgtcaagg aagagctgag    420

gtttgccatc cagaacaagc acctctgcca ccggattcct cattgaatcc tcattttata    480

cccaaaaccc tgaagccatt ggagagctgt cttcctgtgt acctctagaa tcccagcagc    540

agagaaccat caaggcggga gggcctgcag tgattcagca ggcccttccc attctgcccc    600

agagtgggtc ttggaccagg gcaagtgcat ctttgcctca actccaggat ttaggcctta    660

acacactggc cattcttatg ttccagatgg cccccagctg gtgtcctgcc cgcctttcat    720

ctggattcta caaaaaacca ggatgcccac cgttaggatt caggcagcag tgtctgtacc    780

tcgggtggga gggatggggc catctccttc accgtggcta ccattgtcac tcgtagggga    840

tgtggagtga gaacagcatt tagtgaagtt gtgcaacggc cagggttgtg ctttctagca    900

aatatgctgt tatgtccaga aattgtgtgt gcaagaaaac taggcaatgt actcttccga    960

tgtttgtgtc acacaacact gatgtgactt ttatatgctt tttctcagat ctggtttcta   1020

agagttttgg ggggcggggc tgtcaccacg tgcagtatct caagatattc aggtggccag   1080

aagagcttgt cagcaagagg aggacagaat tctcccagcg ttaacacaaa atccatgggc   1140

agtatgatgg caggtcctct gttgcaaact cagttccaaa gtcacaggaa gaaagcagaa   1200

agttcaactt ccaaagggtt aggactctcc actcaatgtc ttaggtcagg agttgtgtct   1260

aggctggaag agccaaagaa tattccattt tcctttcctt gtggttgaaa accacagtca   1320

gtggagagat gtttggaaac cacagtcagt ggagcctggg tggtacccag gctttagcat   1380

tattggatgt caatagcatt gtttttgtca tgtagctgtt ttaagaaatc tggcccaggg   1440

tgtttgcagc tgtgagaagt cactcacact ggccacaagg acgctggcta ctgtctatta   1500

aaattctgat gtttctgtga aattctcaga gtgtttaatt gtactcaatg gtatcattac   1560

aattttctgt aagagaaaat attacttatt tatcctagta ttcctaacct gtcagaataa   1620

taaatattgg aaccaagaca tggtaaacat g                                  1651


<210>  6972
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  6972

Met Gln Arg Ser Pro Ser His Ser Arg Thr Gln Pro Gly Ala His Cys 
1               5                   10                  15      


Thr Ala Leu Phe Ser Arg Arg Arg Pro Ser Ala Pro Phe Ser Pro Arg 
            20                  25                  30          


Ala Gly Arg Glu Ser Ser Val Leu Ala Arg Arg Pro Asp Lys Gln Pro 
        35                  40                  45              


Ala Arg Pro Arg Pro Asp Pro Gly Arg Pro Glu Arg Ser Leu Glu Gln 
    50                  55                  60                  


Asn Asp Ala Ser Thr Pro Arg Pro Gly Leu Cys Leu Gly Ser Glu Cys 
65                  70                  75                  80  


Phe Cys His Arg Pro Leu Pro Val Pro Ser Trp Val Thr Gly Val 
                85                  90                  95  


<210>  6973
<211>  2085
<212>  DNA
<213>  Homosapiens

<400>  6973
acagtcgcac gcagccaggc gcgcactgca cagctctctt ctctcgccgc cgcccgagcg     60

cacccttcag cccgcgcgcc ggccgtgagt cctcggtgct cgcccgccgg ccagacaaac    120

agcccgcccg accccgtccc gaccctggcc gccccgagcg gagcctggag caaaatgatg    180

cttcaacacc caggccaggt ctctgcctcg gaagtgagtg cttctgccat cgtcccctgc    240

ctgtcccctc ctgggtcact ggtgtttgag gattttgcta acctgacgcc ctttgtcaag    300

gaagagctga ggtttgccat ccagaacaag cacctctgcc accggatgtc ctctgcgctg    360

gaatcagtca ctgtcagcga cagacccctc ggggtgtcca tcacaaaagc cgaggtagcc    420

cctgaagaag atgaaaggaa aaagaggcga cgagaaagaa ataagattgc agctgcaaag    480

tgccgaaaca agaagaagga gaagacggag tgcctgcact tcagtattag cagagccaca    540

ggccgcctct gtggcatcac cagggtttct ctgaagaaga gggtctgcat tttcctaaac    600

ccagtgctgc tctcccatct cccatcttcc tctcgcagct tgatgagccc cggtgtgtcc    660

caggagtcgg agaagctgga aagtgtgaat gctgaactga aggctcagat tgaggagctc    720

aagaacgaga agcagcattt gatatacatg ctcaaccttc atcggcccac gtgtattgtc    780

cgggctcaga atgggaggac tccagaagat gagagaaacc tctttatcca acagataaaa    840

gaaggaacat tgcagagcta agcagtcgtg gtatgggggc gactggggag tcctcattga    900

atcctcattt tatacccaaa accctgaagc cattggagag ctgtcttcct gtgtacctct    960

agaatcccag cagcagagaa ccatcaaggc gggagggcct gcagtgattc agcaggccct   1020

tcccattctg ccccagagtg ggtcttggac cagggcaagt gcatctttgc ctcaactcca   1080

ggatttaggc cttaacacac tggccattct tatgttccag atggccccca gctggtgtcc   1140

tgcccgcctt tcatctggat tctacaaaaa accaggatgc ccaccgttag gattcaggca   1200

gcagtgtctg tacctcgggt gggagggatg gggccatctc cttcaccgtg gctaccattg   1260

tcactcgtag gggatgtgga gtgagaacag catttagtga agttgtgcaa cggccagggt   1320

tgtgctttct agcaaatatg ctgttatgtc cagaaattgt gtgtgcaaga aaactaggca   1380

atgtactctt ccgatgtttg tgtcacacaa cactgatgtg acttttatat gctttttctc   1440

agatctggtt tctaagagtt ttggggggcg gggctgtcac cacgtgcagt atctcaagat   1500

attcaggtgg ccagaagagc ttgtcagcaa gaggaggaca gaattctccc agcgttaaca   1560

caaaatccat gggcagtatg atggcaggtc ctctgttgca aactcagttc caaagtcaca   1620

ggaagaaagc agaaagttca acttccaaag ggttaggact ctccactcaa tgtcttaggt   1680

caggagttgt gtctaggctg gaagagccaa agaatattcc attttccttt ccttgtggtt   1740

gaaaaccaca gtcagtggag agatgtttgg aaaccacagt cagtggagcc tgggtggtac   1800

ccaggcttta gcattattgg atgtcaatag cattgttttt gtcatgtagc tgttttaaga   1860

aatctggccc agggtgtttg cagctgtgag aagtcactca cactggccac aaggacgctg   1920

gctactgtct attaaaattc tgatgtttct gtgaaattct cagagtgttt aattgtactc   1980

aatggtatca ttacaatttt ctgtaagaga aaatattact tatttatcct agtattccta   2040

acctgtcaga ataataaata ttggaaccaa gacatggtaa acatg                   2085


<210>  6974
<211>  228
<212>  PRT
<213>  Homosapiens

<400>  6974

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu His Phe Ser Ile Ser Arg Ala Thr Gly Arg Leu Cys Gly Ile 
        115                 120                 125             


Thr Arg Val Ser Leu Lys Lys Arg Val Cys Ile Phe Leu Asn Pro Val 
    130                 135                 140                 


Leu Leu Ser His Leu Pro Ser Ser Ser Arg Ser Leu Met Ser Pro Gly 
145                 150                 155                 160 


Val Ser Gln Glu Ser Glu Lys Leu Glu Ser Val Asn Ala Glu Leu Lys 
                165                 170                 175     


Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln His Leu Ile Tyr Met 
            180                 185                 190         


Leu Asn Leu His Arg Pro Thr Cys Ile Val Arg Ala Gln Asn Gly Arg 
        195                 200                 205             


Thr Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln Gln Ile Lys Glu Gly 
    210                 215                 220                 


Thr Leu Gln Ser 
225             


<210>  6975
<211>  3067
<212>  DNA
<213>  Homosapiens

<400>  6975
acagtcgcac gcagccaggc gcgcactgca cagctctctt ctctcgccgc cgcccgagcg     60

cacccttcag cccgcgcgcc ggccgtgagt cctcggtgct cgcccgccgg ccagacaaac    120

agcccgcccg accccgtccc gaccctggcc gccccgagcg gagcctggag caaaatgatg    180

cttcaacacc caggccaggt ctctgcctcg gaagtgagtg cttctgccat cgtcccctgc    240

ctgtcccctc ctgggtcact ggtgtttgag gattttgcta acctgacgcc ctttgtcaag    300

gaagagctga ggtttgccat ccagaacaag cacctctgcc accggatgtc ctctgcgctg    360

gaatcagtca ctgtcagcga cagacccctc ggggtgtcca tcacaaaagc cgaggtagcc    420

cctgaagaag atgaaaggaa aaagaggcga cgagaaagaa ataagattgc agctgcaaag    480

tgccgaaaca agaagaagga gaagacggag tgcctgcaga aagtgagtgc cttctagcct    540

tacccttcct ctcgctcacg cctgtcttca ccagcttcat gtggctatca gaagaagagt    600

tagaaaaccc cctacttggt tatagtttcc caagaagggc cttgtagctg gtagcagaaa    660

tgccagttgc agaatgagga ggtggcaaag cagttaacac aatggatgtg acggtggatg    720

tataaaaaca ggtgtgtgaa ttcgtctgat gcctgactcc cagcagcctc ggccggttca    780

tacatgtcca tcagcttcca ggctgcagga catgccagcc cagttaaaga ggcttcactt    840

gactgttttc ctgagaaaag gaagctgcca gctctcattt ggctcactat gaaaagcctt    900

taattaatct cttcaaacaa gttatttcct taatccacaa gcagtggtta cacttgcttt    960

gcattcttgt ctggttccta actctagagc ccttctccct ggcttagcca gtaagctgag   1020

cccctggctg cgttcagccg gcccgcctga gagacactag gggaaatagc ttttgtgggc   1080

aagcagggtg gccggtggtg ctcagcagtc tttccagtgg ctgtgtccct cctccaaatg   1140

tggacaggcc atgacagagt cttagcccaa gtcccacaga tccccaaaag ttctgttgat   1200

tgcttcaggg gatcagtgaa aattagggaa ttttgtgtgt tgctatatac attttttctg   1260

gggagatgag cttctcattg agatctgtga ctcagaatcg actaagccac cataagtctg   1320

gatttctccc cagctcccaa ggcccttttg ggtccagaag acctgcatat gggctgttga   1380

ctcatgcaaa tgaggtatct gaactgcagc ttcagtatta gcagagccac aggccgcctc   1440

tgtggcatca ccagggtttc tctgaagaag agggtctgca ttttcctaaa cccagtgctg   1500

ctctcccatc tcccatcttc ctctcgcagc ttgatgagcc ccggtgtgtc ccaggtacac   1560

ccctgcatcc aggcagcagc ccaggccacc ccctcctcac tggcccttgg ctcctttctt   1620

gatgcctctg ttgcttgtcc cccaggagtc ggagaagctg gaaagtgtga atgctgaact   1680

gaaggctcag attgaggagc tcaagaacga gaagcagcat ttgatataca tgctcaacct   1740

tcatcggccc acgtgtattg tccgggctca gaatgggagg actccagaag atgagagaaa   1800

cctctttatc caacagataa aagaaggaac attgcagagc taagcagtcg tggtatgggg   1860

gcgactgggg agtcctcatt gaatcctcat tttataccca aaaccctgaa gccattggag   1920

agctgtcttc ctgtgtacct ctagaatccc agcagcagag aaccatcaag gcgggagggc   1980

ctgcagtgat tcagcaggcc cttcccattc tgccccagag tgggtcttgg accagggcaa   2040

gtgcatcttt gcctcaactc caggatttag gccttaacac actggccatt cttatgttcc   2100

agatggcccc cagctggtgt cctgcccgcc tttcatctgg attctacaaa aaaccaggat   2160

gcccaccgtt aggattcagg cagcagtgtc tgtacctcgg gtgggaggga tggggccatc   2220

tccttcaccg tggctaccat tgtcactcgt aggggatgtg gagtgagaac agcatttagt   2280

gaagttgtgc aacggccagg gttgtgcttt ctagcaaata tgctgttatg tccagaaatt   2340

gtgtgtgcaa gaaaactagg caatgtactc ttccgatgtt tgtgtcacac aacactgatg   2400

tgacttttat atgctttttc tcagatctgg tttctaagag ttttgggggg cggggctgtc   2460

accacgtgca gtatctcaag atattcaggt ggccagaaga gcttgtcagc aagaggagga   2520

cagaattctc ccagcgttaa cacaaaatcc atgggcagta tgatggcagg tcctctgttg   2580

caaactcagt tccaaagtca caggaagaaa gcagaaagtt caacttccaa agggttagga   2640

ctctccactc aatgtcttag gtcaggagtt gtgtctaggc tggaagagcc aaagaatatt   2700

ccattttcct ttccttgtgg ttgaaaacca cagtcagtgg agagatgttt ggaaaccaca   2760

gtcagtggag cctgggtggt acccaggctt tagcattatt ggatgtcaat agcattgttt   2820

ttgtcatgta gctgttttaa gaaatctggc ccagggtgtt tgcagctgtg agaagtcact   2880

cacactggcc acaaggacgc tggctactgt ctattaaaat tctgatgttt ctgtgaaatt   2940

ctcagagtgt ttaattgtac tcaatggtat cattacaatt ttctgtaaga gaaaatatta   3000

cttatttatc ctagtattcc taacctgtca gaataataaa tattggaacc aagacatggt   3060

aaacatg                                                             3067


<210>  6976
<211>  120
<212>  PRT
<213>  Homosapiens

<400>  6976

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Val Ser Ala Phe 
        115                 120 


<210>  6977
<211>  2278
<212>  DNA
<213>  Homosapiens

<400>  6977
cacgcagcca ggcgcgcact gcacagctct cttctctcgc cgccgcccga gcgcaccctt     60

cagcccgcgc gccggccgtg agtcctcggt gctcgcccgc cggccagaca aacagcccgc    120

ccgaccccgt cccgaccctg gccgccccga gcggagcctg gaggtgagcg ctggaagccg    180

agggagtgag cgcgacgagg gctgctcgcc ttcattccct tcgcgcccct ctaagtaacc    240

agtccgccga cccctgaccc accccggatc cgcgccccca gcctccggct tggaaataac    300

tctggcttaa acttcttcta agccaccgct gctcctcggc gcttcgaaaa gtttcccgca    360

aagcgaaaga actaactttc tcttttgact tggggcgcga aaggttcctg gtgacggagg    420

tcgggcgtcc actctgccgc cagcctcgag cgccgcttct ctccgccgac ggcgctggct    480

tgcccggctg ggagagggcg taagcaaaat gatgcttcaa cacccaggcc aggtctctgc    540

ctcggaagtg agtgcttctg ccatcgtccc ctgcctgtcc cctcctgggt cactggtgtt    600

tgaggatttt gctaacctga cgccctttgt caaggaagag ctgaggtttg ccatccagaa    660

caagcacctc tgccaccgga tgtcctctgc gctggaatca gtcactgtca gcgacagacc    720

cctcggggtg tccatcacaa aagccgaggt agcccctgaa gaagatgaaa ggaaaaagag    780

gcgacgagaa agaaataaga ttgcagctgc aaagtgccga aacaagaaga aggagaagac    840

ggagtgcctg cagaaagagt cggagaagct ggaaagtgtg aatgctgaac tgaaggctca    900

gattgaggag ctcaagaacg agaagcagca tttgatatac atgctcaacc ttcatcggcc    960

cacgtgtatt gtccgggctc agaatgggag gactccagaa gatgagagaa acctctttat   1020

ccaacagata aaagaaggaa cattgcagag ctaagcagtc gtggtatggg ggcgactggg   1080

gagtcctcat tgaatcctca ttttataccc aaaaccctga agccattgga gagctgtctt   1140

cctgtgtacc tctagaatcc cagcagcaga gaaccatcaa ggcgggaggg cctgcagtga   1200

ttcagcaggc ccttcccatt ctgccccaga gtgggtcttg gaccagggca agtgcatctt   1260

tgcctcaact ccaggattta ggccttaaca cactggccat tcttatgttc cagatggccc   1320

ccagctggtg tcctgcccgc ctttcatctg gattctacaa aaaaccagga tgcccaccgt   1380

taggattcag gcagcagtgt ctgtacctcg ggtgggaggg atggggccat ctccttcacc   1440

gtggctacca ttgtcactcg taggggatgt ggagtgagaa cagcatttag tgaagttgtg   1500

caacggccag ggttgtgctt tctagcaaat atgctgttat gtccagaaat tgtgtgtgca   1560

agaaaactag gcaatgtact cttccgatgt ttgtgtcaca caacactgat gtgactttta   1620

tatgcttttt ctcagatctg gtttctaaga gttttggggg gcggggctgt caccacgtgc   1680

agtatctcaa gatattcagg tggccagaag agcttgtcag caagaggagg acagaattct   1740

cccagcgtta acacaaaatc catgggcagt atgatggcag gtcctctgtt gcaaactcag   1800

ttccaaagtc acaggaagaa agcagaaagt tcaacttcca aagggttagg actctccact   1860

caatgtctta ggtcaggagt tgtgtctagg ctggaagagc caaagaatat tccattttcc   1920

tttccttgtg gttgaaaacc acagtcagtg gagagatgtt tggaaaccac agtcagtgga   1980

gcctgggtgg tacccaggct ttagcattat tggatgtcaa tagcattgtt tttgtcatgt   2040

agctgtttta agaaatctgg cccagggtgt ttgcagctgt gagaagtcac tcacactggc   2100

cacaaggacg ctggctactg tctattaaaa ttctgatgtt tctgtgaaat tctcagagtg   2160

tttaattgta ctcaatggta tcattacaat tttctgtaag agaaaatatt acttatttat   2220

cctagtattc ctaacctgtc agaataataa atattggaac caagacatgg taaacatg     2278


<210>  6978
<211>  181
<212>  PRT
<213>  Homosapiens

<400>  6978

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Glu Ser Glu Lys Leu Glu Ser Val Asn Ala Glu Leu 
        115                 120                 125             


Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln His Leu Ile Tyr 
    130                 135                 140                 


Met Leu Asn Leu His Arg Pro Thr Cys Ile Val Arg Ala Gln Asn Gly 
145                 150                 155                 160 


Arg Thr Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln Gln Ile Lys Glu 
                165                 170                 175     


Gly Thr Leu Gln Ser 
            180     


<210>  6979
<211>  2490
<212>  DNA
<213>  Homosapiens

<400>  6979
atgataacac ataatggagt aagtgggctt caaatcttca tcttctgacc tcagtctggg     60

aattttgtgg ataagagacc cacttgctca cactcccaga aggcagttag caagcagcct    120

gggtatgcac cgtgacataa agattagcag ttcattaaac agagttcagt ttatcccgag    180

gaatctttac ttagcctccc ctctatcact tcatttccag gcctcccacc taccttaagg    240

cctgccccga gaaaatttgc tctggttttt tgtttgtttg tgcaatataa cataatgctt    300

gtttgttttt gtaatgtaga ataatatttg tttgtttttt gcaatgtaca aattaagggc    360

atgaatcctg gagccaaact aacttaattc caaatcctga tgctgcccca tattaattct    420

gtgaattcgg gcaaatgact tagtttgtct aaacctcaat tatctcatct ataaaaggca    480

gctagatctt aactcactgg gttctcgtga ggattaaatg agatagtgcc cctaaggttt    540

ctggtatgaa ggaggcactc cttaaatgtt cgagacttgc cagagggctt cttctctgtc    600

tggactgtgc taatgaccac agatccccgg ttgagaggaa tgcccagacc acactcatcc    660

tacactcatc cctatactca ttgtcccttg ggaaccaact gcagggagga ggggaaatgg    720

ccaccactgg agggagtaca cagcaggcca agacttatgg gggactcttc caaattgggg    780

ccatggaact gtcactattt ctactcttta ttttcctttt gtcatccttt tgggttcacc    840

gagctataga ataacagagg gagatgaatt tagcaaatac atcactgaag cttctccctc    900

ggaagttggg cccaagcaat gggaatgaga aaggtaacct tggaccgtgg gggccatttg    960

atttgatgac cccatcccca cttcatttat cagttggcca atgaggcatg gcgagtcagg   1020

cattgggcca ggctctgggt aaagcaatgg tggagactca atgcttgcat tggaggagct   1080

ctggaaagtg tgaatgctga actgaaggct cagattgagg agctcaagaa cgagaagcag   1140

catttgatat acatgctcaa ccttcatcgg cccacgtgta ttgtccgggc tcagaatggg   1200

aggactccag aagatgagag aaacctcttt atccaacaga taaaagaagg aacattgcag   1260

agctaagcag tcgtggtatg ggggcgactg gggagtcctc attgaatcct cattttatac   1320

ccaaaaccct gaagccattg gagagctgtc ttcctgtgta cctctagaat cccagcagca   1380

gagaaccatc aaggcgggag ggcctgcagt gattcagcag gcccttccca ttctgcccca   1440

gagtgggtct tggaccaggg caagtgcatc tttgcctcaa ctccaggatt taggccttaa   1500

cacactggcc attcttatgt tccagatggc ccccagctgg tgtcctgccc gcctttcatc   1560

tggattctac aaaaaaccag gatgcccacc gttaggattc aggcagcagt gtctgtacct   1620

cgggtgggag ggatggggcc atctccttca ccgtggctac cattgtcact cgtaggggat   1680

gtggagtgag aacagcattt agtgaagttg tgcaacggcc agggttgtgc tttctagcaa   1740

atatgctgtt atgtccagaa attgtgtgtg caagaaaact aggcaatgta ctcttccgat   1800

gtttgtgtca cacaacactg atgtgacttt tatatgcttt ttctcagatc tggtttctaa   1860

gagttttggg gggcggggct gtcaccacgt gcagtatctc aagatattca ggtggccaga   1920

agagcttgtc agcaagagga ggacagaatt ctcccagcgt taacacaaaa tccatgggca   1980

gtatgatggc aggtcctctg ttgcaaactc agttccaaag tcacaggaag aaagcagaaa   2040

gttcaacttc caaagggtta ggactctcca ctcaatgtct taggtcagga gttgtgtcta   2100

ggctggaaga gccaaagaat attccatttt cctttccttg tggttgaaaa ccacagtcag   2160

tggagagatg tttggaaacc acagtcagtg gagcctgggt ggtacccagg ctttagcatt   2220

attggatgtc aatagcattg tttttgtcat gtagctgttt taagaaatct ggcccagggt   2280

gtttgcagct gtgagaagtc actcacactg gccacaagga cgctggctac tgtctattaa   2340

aattctgatg tttctgtgaa attctcagag tgtttaattg tactcaatgg tatcattaca   2400

attttctgta agagaaaata ttacttattt atcctagtat tcctaacctg tcagaataat   2460

aaatattgga accaagacat ggtaaacatg                                    2490


<210>  6980
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  6980

Met Ala Ser Gln Ala Leu Gly Gln Ala Leu Gly Lys Ala Met Val Glu 
1               5                   10                  15      


Thr Gln Cys Leu His Trp Arg Ser Ser Gly Lys Cys Glu Cys 
            20                  25                  30  


<210>  6981
<211>  648
<212>  DNA
<213>  Homosapiens

<400>  6981
gcaatataac ataatgcttg tttgtttttg taatgtagaa taatatttgt ttgttttttg     60

caatgtacaa attaagggca tgaatcctgg agccaaacta acttaattcc aaatcctgat    120

gctgccccat attaattctg tgaattcggg caaatgactt agtttgtcta aacctcaatt    180

atctcatcta taaaaggcag ctagatctta actcactggg ttctcgtgag gattaaatga    240

gatagtgccc ctaaggtttc tggtatgaag gaggcactcc ttaaatgttc gagacttgcc    300

agagggcttc ttctctgtct ggactgtgct aatgaccaca gatccccggt tgagaggaat    360

gcccagacca cactcatcct acactcatcc ctatactcat tgtcccttgg gaaccaactg    420

cagggaggag gggaaatggc caccactgga gggagtacac agcaggccaa gacttatggg    480

ggactcttcc aaattggggc catggaactg tcactatttg ctaaattcaa ggattcccca    540

ctttttgctt ttacttccac tcactgatag tttcagcttg acgtcaagcc tctttgaaaa    600

agaggctttt ttttttaagt gaaagaaact ttattttgag taatatac                 648


<210>  6982
<211>  100
<212>  PRT
<213>  Homosapiens

<400>  6982

Met Lys Glu Ala Leu Leu Lys Cys Ser Arg Leu Ala Arg Gly Leu Leu 
1               5                   10                  15      


Leu Cys Leu Asp Cys Ala Asn Asp His Arg Ser Pro Val Glu Arg Asn 
            20                  25                  30          


Ala Gln Thr Thr Leu Ile Leu His Ser Ser Leu Tyr Ser Leu Ser Leu 
        35                  40                  45              


Gly Asn Gln Leu Gln Gly Gly Gly Glu Met Ala Thr Thr Gly Gly Ser 
    50                  55                  60                  


Thr Gln Gln Ala Lys Thr Tyr Gly Gly Leu Phe Gln Ile Gly Ala Met 
65                  70                  75                  80  


Glu Leu Ser Leu Phe Ala Lys Phe Lys Asp Ser Pro Leu Phe Ala Phe 
                85                  90                  95      


Thr Ser Thr His 
            100 


<210>  6983
<211>  2932
<212>  DNA
<213>  Homosapiens

<400>  6983
ccctgaaaca gtttgggttt caatgtgtct ttcagcaaaa tgatgcttca acacccaggc     60

caggtctctg cctcggaagt gagtgcttct gccatcgtcc cctgcctgtc ccctcctggg    120

tcactggtgt ttgaggattt tgctaacctg acgccctttg tcaaggaaga gctgaggttt    180

gccatccaga acaagcacct ctgccaccgg atgtcctctg cgctggaatc agtcactgtc    240

agcgacagac ccctcggggt gtccatcaca aaagccgagg tagcccctga agaagatgaa    300

aggaaaaaga ggcgacgaga aagaaataag attgcagctg caaagtgccg aaacaagaag    360

aaggagaaga cggagtgcct gcagaaagtg agtgccttct agccttaccc ttcctctcgc    420

tcacgcctgt cttcaccagc ttcatgtggc tatcagaaga agagttagaa aaccccctac    480

ttggttatag tttcccaaga agggccttgt agctggtagc agaaatgcca gttgcagaat    540

gaggaggtgg caaagcagtt aacacaatgg atgtgacggt ggatgtataa aaacaggtgt    600

gtgaattcgt ctgatgcctg actcccagca gcctcggccg gttcatacat gtccatcagc    660

ttccaggctg caggacatgc cagcccagtt aaagaggctt cacttgactg ttttcctgag    720

aaaaggaagc tgccagctct catttggctc actatgaaaa gcctttaatt aatctcttca    780

aacaagttat ttccttaatc cacaagcagt ggttacactt gctttgcatt cttgtctggt    840

tcctaactct agagcccttc tccctggctt agccagtaag ctgagcccct ggctgcgttc    900

agccggcccg cctgagagac actaggggaa atagcttttg tgggcaagca gggtggccgg    960

tggtgctcag cagtctttcc agtggctgtg tccctcctcc aaatgtggac aggccatgac   1020

agagtcttag cccaagtccc acagatcccc aaaagttctg ttgattgctt caggggatca   1080

gtgaaaatta gggaattttg tgtgttgcta tatacatttt ttctggggag atgagcttct   1140

cattgagatc tgtgactcag aatcgactaa gccaccataa gtctggattt ctccccagct   1200

cccaaggccc ttttgggtcc agaagacctg catatgggct gttgactcat gcaaatgagg   1260

tatctgaact gcagcttcag tattagcaga gccacaggcc gcctctgtgg catcaccagg   1320

gtttctctga agaagagggt ctgcattttc ctaaacccag tgctgctctc ccatctccca   1380

tcttcctctc gcagcttgat gagccccggt gtgtcccagg tacacccctg catccaggca   1440

gcagcccagg ccaccccctc ctcactggcc cttggctcct ttcttgatgc ctctgttgct   1500

tgtcccccag gagtcggaga agctggaaag tgtgaatgct gaactgaagg ctcagattga   1560

ggagctcaag aacgagaagc agcatttgat atacatgctc aaccttcatc ggcccacgtg   1620

tattgtccgg gctcagaatg ggaggactcc agaagatgag agaaacctct ttatccaaca   1680

gataaaagaa ggaacattgc agagctaagc agtcgtggta tgggggcgac tggggagtcc   1740

tcattgaatc ctcattttat acccaaaacc ctgaagccat tggagagctg tcttcctgtg   1800

tacctctaga atcccagcag cagagaacca tcaaggcggg agggcctgca gtgattcagc   1860

aggcccttcc cattctgccc cagagtgggt cttggaccag ggcaagtgca tctttgcctc   1920

aactccagga tttaggcctt aacacactgg ccattcttat gttccagatg gcccccagct   1980

ggtgtcctgc ccgcctttca tctggattct acaaaaaacc aggatgccca ccgttaggat   2040

tcaggcagca gtgtctgtac ctcgggtggg agggatgggg ccatctcctt caccgtggct   2100

accattgtca ctcgtagggg atgtggagtg agaacagcat ttagtgaagt tgtgcaacgg   2160

ccagggttgt gctttctagc aaatatgctg ttatgtccag aaattgtgtg tgcaagaaaa   2220

ctaggcaatg tactcttccg atgtttgtgt cacacaacac tgatgtgact tttatatgct   2280

ttttctcaga tctggtttct aagagttttg gggggcgggg ctgtcaccac gtgcagtatc   2340

tcaagatatt caggtggcca gaagagcttg tcagcaagag gaggacagaa ttctcccagc   2400

gttaacacaa aatccatggg cagtatgatg gcaggtcctc tgttgcaaac tcagttccaa   2460

agtcacagga agaaagcaga aagttcaact tccaaagggt taggactctc cactcaatgt   2520

cttaggtcag gagttgtgtc taggctggaa gagccaaaga atattccatt ttcctttcct   2580

tgtggttgaa aaccacagtc agtggagaga tgtttggaaa ccacagtcag tggagcctgg   2640

gtggtaccca ggctttagca ttattggatg tcaatagcat tgtttttgtc atgtagctgt   2700

tttaagaaat ctggcccagg gtgtttgcag ctgtgagaag tcactcacac tggccacaag   2760

gacgctggct actgtctatt aaaattctga tgtttctgtg aaattctcag agtgtttaat   2820

tgtactcaat ggtatcatta caattttctg taagagaaaa tattacttat ttatcctagt   2880

attcctaacc tgtcagaata ataaatattg gaaccaagac atggtaaaca tg           2932


<210>  6984
<211>  120
<212>  PRT
<213>  Homosapiens

<400>  6984

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Val Ser Ala Phe 
        115                 120 


<210>  6985
<211>  1776
<212>  DNA
<213>  Homosapiens

<400>  6985
agcaaaatga tgcttcaaca cccaggccag gtctctgcct cggaagtgag tgcttctgcc     60

atcgtcccct gcctgtcccc tcctgggtca ctggtgtttg aggattttgc taacctgacg    120

ccctttgtca aggaagagct gaggtttgcc atccagaaca agcacctctg ccaccggatg    180

tcctctgcgc tggaatcagt cactgtcagc gacagacccc tcggggtgtc catcacaaaa    240

gccgaggtag cccctgaaga agatgaaagg aaaaagaggc gacgagaaag aaataagatt    300

gcagctgcaa agtgccgaaa caagaagaag gagaagacgg agtgcctgca gaaagagtcg    360

gagaagctgg aaagtgtgaa tgctgaactg aaggctcaga ttgaggagct caagaacgag    420

aagcagcatt tgatatacat gctcaacctt catcggccca cgtgtattgt ccgggctcag    480

aatgggagga ctccagaaga tgagagaaac ctctttatcc aacagataaa agaaggaaca    540

ttgcagagct aagcagtcgt ggtatggggg cgactgggga gtcctcattg aatcctcatt    600

ttatacccaa aaccctgaag ccattggaga gctgtcttcc tgtgtacctc tagaatccca    660

gcagcagaga accatcaagg cgggagggcc tgcagtgatt cagcaggccc ttcccattct    720

gccccagagt gggtcttgga ccagggcaag tgcatctttg cctcaactcc aggatttagg    780

ccttaacaca ctggccattc ttatgttcca gatggccccc agctggtgtc ctgcccgcct    840

ttcatctgga ttctacaaaa aaccaggatg cccaccgtta ggattcaggc agcagtgtct    900

gtacctcggg tgggagggat ggggccatct ccttcaccgt ggctaccatt gtcactcgta    960

ggggatgtgg agtgagaaca gcatttagtg aagttgtgca acggccaggg ttgtgctttc   1020

tagcaaatat gctgttatgt ccagaaattg tgtgtgcaag aaaactaggc aatgtactct   1080

tccgatgttt gtgtcacaca acactgatgt gacttttata tgctttttct cagatctggt   1140

ttctaagagt tttggggggc ggggctgtca ccacgtgcag tatctcaaga tattcaggtg   1200

gccagaagag cttgtcagca agaggaggac agaattctcc cagcgttaac acaaaatcca   1260

tgggcagtat gatggcaggt cctctgttgc aaactcagtt ccaaagtcac aggaagaaag   1320

cagaaagttc aacttccaaa gggttaggac tctccactca atgtcttagg tcaggagttg   1380

tgtctaggct ggaagagcca aagaatattc cattttcctt tccttgtggt tgaaaaccac   1440

agtcagtgga gagatgtttg gaaaccacag tcagtggagc ctgggtggta cccaggcttt   1500

agcattattg gatgtcaata gcattgtttt tgtcatgtag ctgttttaag aaatctggcc   1560

cagggtgttt gcagctgtga gaagtcactc acactggcca caaggacgct ggctactgtc   1620

tattaaaatt ctgatgtttc tgtgaaattc tcagagtgtt taattgtact caatggtatc   1680

attacaattt tctgtaagag aaaatattac ttatttatcc tagtattcct aacctgtcag   1740

aataataaat attggaacca agacatggta aacatg                             1776


<210>  6986
<211>  181
<212>  PRT
<213>  Homosapiens

<400>  6986

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Glu Ser Glu Lys Leu Glu Ser Val Asn Ala Glu Leu 
        115                 120                 125             


Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln His Leu Ile Tyr 
    130                 135                 140                 


Met Leu Asn Leu His Arg Pro Thr Cys Ile Val Arg Ala Gln Asn Gly 
145                 150                 155                 160 


Arg Thr Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln Gln Ile Lys Glu 
                165                 170                 175     


Gly Thr Leu Gln Ser 
            180     


<210>  6987
<211>  1995
<212>  DNA
<213>  Homosapiens

<400>  6987
atgatgcttc aacacccagg ccaggtctct gcctcggaag aagagctgag gtttgccatc     60

cagaacaagc acctctgcca ccggatgtcc tctgcgctgg aatcagtcac tgtcagcgac    120

agacccctcg gggtgtccat cacaaaagcc gaggtagccc ctgaagaaga tgaaaggaaa    180

aagaggcgac gagaaagaaa taagattgca gctgcaaagt gccgaaacaa gaagaaggag    240

aagacggagt gcctgcagaa actcccaagg cccttttggg tccagaagac ctgcatatgg    300

gctgttgact catgcaaatg aggtatctga actgcagctt cagtattagc agagccacag    360

gccgcctctg tggcatcacc agggtttctc tgaagaagag ggtctgcatt ttcctaaacc    420

cagtgctgct ctcccatctc ccatcttcct ctcgcagctt gatgagcccc ggtgtgtccc    480

aggtacaccc ctgcatccag gcagcagccc aggccacccc ctcctcactg gcccttggct    540

cctttcttga tgcctctgtt gcttgtcccc caggagtcgg agaagctgga aagtgtgaat    600

gctgaactga aggctcagat tgaggagctc aagaacgaga agcagcattt gatatacatg    660

ctcaaccttc atcggcccac gtgtattgtc cgggctcaga atgggaggac tccagaagat    720

gagagaaacc tctttatcca acagataaaa gaaggaacat tgcagagcta agcagtcgtg    780

gtatgggggc gactggggag tcctcattga atcctcattt tatacccaaa accctgaagc    840

cattggagag ctgtcttcct gtgtacctct agaatcccag cagcagagaa ccatcaaggc    900

gggagggcct gcagtgattc agcaggccct tcccattctg ccccagagtg ggtcttggac    960

cagggcaagt gcatctttgc ctcaactcca ggatttaggc cttaacacac tggccattct   1020

tatgttccag atggccccca gctggtgtcc tgcccgcctt tcatctggat tctacaaaaa   1080

accaggatgc ccaccgttag gattcaggca gcagtgtctg tacctcgggt gggagggatg   1140

gggccatctc cttcaccgtg gctaccattg tcactcgtag gggatgtgga gtgagaacag   1200

catttagtga agttgtgcaa cggccagggt tgtgctttct agcaaatatg ctgttatgtc   1260

cagaaattgt gtgtgcaaga aaactaggca atgtactctt ccgatgtttg tgtcacacaa   1320

cactgatgtg acttttatat gctttttctc agatctggtt tctaagagtt ttggggggcg   1380

gggctgtcac cacgtgcagt atctcaagat attcaggtgg ccagaagagc ttgtcagcaa   1440

gaggaggaca gaattctccc agcgttaaca caaaatccat gggcagtatg atggcaggtc   1500

ctctgttgca aactcagttc caaagtcaca ggaagaaagc agaaagttca acttccaaag   1560

ggttaggact ctccactcaa tgtcttaggt caggagttgt gtctaggctg gaagagccaa   1620

agaatattcc attttccttt ccttgtggtt gaaaaccaca gtcagtggag agatgtttgg   1680

aaaccacagt cagtggagcc tgggtggtac ccaggcttta gcattattgg atgtcaatag   1740

cattgttttt gtcatgtagc tgttttaaga aatctggccc agggtgtttg cagctgtgag   1800

aagtcactca cactggccac aaggacgctg gctactgtct attaaaattc tgatgtttct   1860

gtgaaattct cagagtgttt aattgtactc aatggtatca ttacaatttt ctgtaagaga   1920

aaatattact tatttatcct agtattccta acctgtcaga ataataaata ttggaaccaa   1980

gacatggtaa acatg                                                    1995


<210>  6988
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  6988

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Glu Glu Leu 
1               5                   10                  15      


Arg Phe Ala Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala 
            20                  25                  30          


Leu Glu Ser Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr 
        35                  40                  45              


Lys Ala Glu Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg 
    50                  55                  60                  


Glu Arg Asn Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu 
65                  70                  75                  80  


Lys Thr Glu Cys Leu Gln Lys Leu Pro Arg Pro Phe Trp Val Gln Lys 
                85                  90                  95      


Thr Cys Ile Trp Ala Val Asp Ser Cys Lys 
            100                 105     


<210>  6989
<211>  1005
<212>  DNA
<213>  Homosapiens

<400>  6989
accagggttt ctctgaagaa gagggtctgc attttcctaa acccagtgct gctctcccat     60

ctcccatctt cctctcgcag cttgatgagc cccggtgtgt cccaggtaca cccctgcatc    120

caggcagcag cccaggccac cccctcctca ctggcccttg gctcctttct tgatgcctct    180

gttgcttgtc ccccaggagt cggagaagct ggaaagtgtg aatgctgaac tgaaggctca    240

gattgaggag ctcaagaacg agaagcagca tttgatatac atgctcaacc ttcatcggcc    300

cacgtgtatt gtccgggctc agaatgggag gactccagaa gatgagagaa acctctttat    360

ccaacagata aaagaaggaa cattgcagag ctaagcagtc gtggtatggg ggcgactggg    420

gagtcctcat tgaatcctca ttttataccc aaaaccctga agccattgga gagctgtctt    480

cctgtgtacc tctagaatcc cagcagcaga gtcctctgtt gcaaactcag ttccaaagtc    540

acaggaagaa agcagaaagt tcaacttcca aagggttagg actctccact caatgtctta    600

ggtcaggagt tgtgtctagg ctggaagagc caaagaatat tccattttcc tttccttgtg    660

gttgaaaacc acagtcagtg gagagatgtt tggaaaccac agtcagtgga gcctgggtgg    720

tacccaggct ttagcattat tggatgtcaa tagcattgtt tttgtcatgt agctgtttta    780

agaaatctgg cccagggtgt ttgcagctgt gagaagtcac tcacactggc cacaaggacg    840

ctggctactg tctattaaaa ttctgatgtt tctgtgaaat tctcagagtg tttaattgta    900

ctcaatggta tcattacaat tttctgtaag agaaaatatt acttatttat cctagtattc    960

ctaacctgtc agaataataa atattggaac caagacatgg taaac                   1005


<210>  6990
<211>  73
<212>  PRT
<213>  Homosapiens

<400>  6990

Met Pro Leu Leu Leu Val Pro Gln Glu Ser Glu Lys Leu Glu Ser Val 
1               5                   10                  15      


Asn Ala Glu Leu Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln 
            20                  25                  30          


His Leu Ile Tyr Met Leu Asn Leu His Arg Pro Thr Cys Ile Val Arg 
        35                  40                  45              


Ala Gln Asn Gly Arg Thr Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln 
    50                  55                  60                  


Gln Ile Lys Glu Gly Thr Leu Gln Ser 
65                  70              


<210>  6991
<211>  2225
<212>  DNA
<213>  Homosapiens

<400>  6991
agatgtatga ttctttattt aaacggcagt aaagaacgct ggaataggct ttccagggac     60

actcccatga gctctgggct cctttgcagc ttccagctct gggtcttatt taatgggctt    120

caaaggtcac tgtctccatg atgtccggtg tcatagaacc aaccgtctcc agcccctggc    180

caccctctgc tgtctcggcg atggccacgt tggtgctcct ctccgccatc ttagccatga    240

cgttcacatc tctgccatgt ggtgtgccca ctacttttgt agtaaggttg gctctgacgt    300

tcctcaggaa agagctgacc ctgccaagtc ccttgctgga accggaactg gtggtccata    360

agctcctccc agatttgtga gaggtcctgg actcctttga gatgggcgtg tggctgacac    420

ctttatgcga gtccctgtgc ctgctgctcc ccgggttgcc acagcctttc tcctttttgt    480

catctctatt ggctctgtgg ctgaatgagg acctgctgga ggacttttgg gcaatcttgt    540

ctccccttgt tttgtggcgg ctttcacctg tcctgcggcg atgggaactc cttccgagag    600

ccctgtcctt ttcccttctt tccctcccct ccttgcagcc ttcagcgctg gcctgggttc    660

gctcccttcc atgctgtcca ctcaggctgc tcttgctctg ccgggtggag acgggaggtc    720

ccgctgctgc atccatgtct gcttctgcag ctgtcctgct ggtcagtact actcctgcaa    780

tggccaggct cacactgccc tctcgggaaa ggctcatgga tgcgctggaa acatgctctg    840

aggacttgcc tgcagcccct gccacagcca ccttcgtgct gtttggagcc atgctggcag    900

tgcctgcaag ggccatgttg cctttgtttc ctcctgcacc gatggtggcc gccccagcta    960

tggctgcgct cacctgtcca ggggcagaat tggctgctgc cacactcaag gcacctgcta   1020

cggtgcctgt tgctgcccct gcagctgccc ctgctgctgc tgcctcttta atcccccctg   1080

ttgctggctc ctcagcaagt tctgtagatg ttttggggat ggatgcattg agcacattag   1140

tgggtttgtt aaagtcattt tggagtccct cccctccagc ataagcagca gaggtggccc   1200

cacacacctc agagaccatg tggaggcttt ggatgctgac ctggtcctga tccccctttc   1260

cttgaaggtt cacggctccc aggctcctcc tgtcttcctg aaacacaggc atccacatca   1320

tgtcttcagc tggaatgcca caggtactgc tgttactctc catgggtggc cgcaagaggt   1380

aaattagttt ttcccaatag gcaaagaggt catcccgtgt gtcaagagcg ggacacaatt   1440

gcagatagca agatctgcca gtggcgaact tcaggcgcag ctgttgtttc tcatggtctt   1500

gaacagagat ccgtacaaac ctcaggggca gaagcctgtt gtcgctgcag tttccccatg   1560

gtggtgttga acatgctcat gctggagcca ctctgggccg tataatacgg cagcagaaaa   1620

tcagcattca tggttgtctt tcagcacaac ggcagcactg gtgaggcagg tctctgggtc   1680

ttccttggcc tcggtggcag atgagggacc agtggtgctc ctgggtcaca aagatgtctc   1740

tgcagctggt ctctcaatcc caccccaccc cacaggcccc cactgttgcc tcagagcctc   1800

ccagaggccg gggtgggggt gggagcacgg atgattgctg tggggggtgc tgtagggtgc   1860

ctggactcca gactcttcca agacgtagag atgcagggtg ggctccagag aggttttctt   1920

ctggacctaa ccccctgacc tccacctctg atttttttaa ttacagtttg tagtctctct   1980

ccctgagaga gactacaaac tgtagtccta gtgacaggaa gtgacgaccc tctctgccta   2040

aaccccctgt gcagccatat ttatcttctg cttccctttg tgacctgttg ctgtcacata   2100

cccctttgtt ctcatccccc aggccagggc cacaatgccc tcactaatac tccattgccc   2160

ccatagagga cagccccacc gtgccaggta ctcaagtggg tgccaaaata aaaatttttc   2220

aaatg                                                               2225


<210>  6992
<211>  260
<212>  PRT
<213>  Homosapiens

<400>  6992

Met Gly Val Trp Leu Thr Pro Leu Cys Glu Ser Leu Cys Leu Leu Leu 
1               5                   10                  15      


Pro Gly Leu Pro Gln Pro Phe Ser Phe Leu Ser Ser Leu Leu Ala Leu 
            20                  25                  30          


Trp Leu Asn Glu Asp Leu Leu Glu Asp Phe Trp Ala Ile Leu Ser Pro 
        35                  40                  45              


Leu Val Leu Trp Arg Leu Ser Pro Val Leu Arg Arg Trp Glu Leu Leu 
    50                  55                  60                  


Pro Arg Ala Leu Ser Phe Ser Leu Leu Ser Leu Pro Ser Leu Gln Pro 
65                  70                  75                  80  


Ser Ala Leu Ala Trp Val Arg Ser Leu Pro Cys Cys Pro Leu Arg Leu 
                85                  90                  95      


Leu Leu Leu Cys Arg Val Glu Thr Gly Gly Pro Ala Ala Ala Ser Met 
            100                 105                 110         


Ser Ala Ser Ala Ala Val Leu Leu Val Ser Thr Thr Pro Ala Met Ala 
        115                 120                 125             


Arg Leu Thr Leu Pro Ser Arg Glu Arg Leu Met Asp Ala Leu Glu Thr 
    130                 135                 140                 


Cys Ser Glu Asp Leu Pro Ala Ala Pro Ala Thr Ala Thr Phe Val Leu 
145                 150                 155                 160 


Phe Gly Ala Met Leu Ala Val Pro Ala Arg Ala Met Leu Pro Leu Phe 
                165                 170                 175     


Pro Pro Ala Pro Met Val Ala Ala Pro Ala Met Ala Ala Leu Thr Cys 
            180                 185                 190         


Pro Gly Ala Glu Leu Ala Ala Ala Thr Leu Lys Ala Pro Ala Thr Val 
        195                 200                 205             


Pro Val Ala Ala Pro Ala Ala Ala Pro Ala Ala Ala Ala Ser Leu Ile 
    210                 215                 220                 


Pro Pro Val Ala Gly Ser Ser Ala Ser Ser Val Asp Val Leu Gly Met 
225                 230                 235                 240 


Asp Ala Leu Ser Thr Leu Val Gly Leu Leu Lys Ser Phe Trp Ser Pro 
                245                 250                 255     


Ser Pro Pro Ala 
            260 


<210>  6993
<211>  2305
<212>  DNA
<213>  Homosapiens

<400>  6993
agagagggtc gtcacttcct gtcactagga ctacagtttg tagtctctct cagggagaga     60

gactacaaac tgtaattaaa aaaatcagag gtggaggtca gggggttagg tccagaagaa    120

aacctctctg gagcccaccc tgcatctcta cgtcttggaa gagtctggag tccaggcacc    180

ctacagcacc ccccacagca atcatccgtg ctcccacccc caccccggcc tctgggaggc    240

tctgaggcaa cagtgggggc ctgtggggtg gggtgggatt gagagaccag ctgcagagac    300

atctttgtga cccaggagca ccactggtcc ctcatctgcc accgaggcca aggaagaccc    360

agagacctgc ctcaccagtg ctgccgttgt gctgaaagac aaccatgaat gctgattttc    420

tgctgccgta ttatacggcc cagagtggct ccagcatgag catgttcaac accaccatgg    480

ggaaactgca gcgacaactg tacaaggggg agtacgatat attcaagtat gcaccgatat    540

ttgagagcga ctttatccag atcaccaaaa ggggagaagt gattgatgtg cacaaccgtg    600

tccgtatggt gaccatgggc attgcacgta ccagccccat cctcccactc ccagatgtca    660

tgctactggc acgaccggcc accggctgcg aagagtatgc tggacatggc caggccacca    720

agagaaaaaa acgcaaggca gcaaagaact tagagctcac caggcttctg cccctgaggt    780

ttgtacggat ctctgttcaa gaccatgaga aacaacagct gcgcctgaag ttcgccactg    840

gcagatcttg ctatctgcaa ttgtgtcccg ctcttgacac acgggatgac ctctttgcct    900

attgggaaaa actaatttac ctcttgcggc cacccatgga gagtaacagc agtacctgtg    960

gcattccagc tgaagacatg atgtggatgc ctgtgtttca ggaagacagg aggagcctgg   1020

gagccgtgaa ccttcaagga aagggggatc aggaccaggt cagcatccaa agcctccaca   1080

tggtctctga ggtgtgtggg gccacctctg ctgcttatgc tggaggggag ggactccaaa   1140

atgactttaa caaacccact aatgtgctca atgcatccat ccccaaaaca tctacagaac   1200

ttgctgagga gccagcaaca ggggggatta aagaggcagc agcagcaggg gcagctgcag   1260

gggcagcaac aggcaccgta gcaggtgcct tgagtgtggc agcagccaat tctgcccctg   1320

gacaggtgag cgcagccata gctggggcgg ccaccatcgg tgcaggagga aacaaaggca   1380

acatggccct tgcaggcact gccagcatgg ctccaaacag cacgaaggtg gctgtggcag   1440

gggctgcagg caagtcctca gagcatgttt ccagcgcatc catgagcctt tcccgagagg   1500

gcagtgtgag cctggccatt gcaggagtag tactgaccag caggacagct gcagaagcag   1560

acatggatgc agcagcggga cctcccgtct ccacccggca gagcaagagc agcctgagtg   1620

gacagcatgg aagggagcga acccaggcca gcgctgaagg ctgcaaggag gggagggaaa   1680

gaagggaaaa ggacagggct ctcggaagga gttcccatcg ccgcaggaca ggtgaaagcc   1740

gccacaaaac aaggggagac aagattgccc aaaagtcctc cagcaggtcc tcattcagcc   1800

acagagccaa tagagatgac aaaaaggaga aaggctgtgg caacccgggg agcagcaggc   1860

acagggactc gcataaaggt gtcagccaca cgcccatctc aaaggagtcc aggacctctc   1920

acaaatctgg gaggagctta tggaccacca gttccggttc cagcaaggga cttggcaggg   1980

tcagctcttt cctgaggaac gtcagagcca accttactac aaaagtagtg ggcacaccac   2040

atggcagaga tgtgaacgtc atggctaaga tggcggagag gagcaccaac gtggccatcg   2100

ccgagacagc agagggtggc caggggctgg agacggttgg ttctatgaca ccggacatca   2160

tggagacagt gacctttgaa gcccattaaa taagacccag agctggaagc tgcaaaggag   2220

cccagagctc atgggagtgt ccctggaaag cctattccag cgttctttac tgccgtttaa   2280

ataaagaatc atacatctga aagtg                                         2305


<210>  6994
<211>  594
<212>  PRT
<213>  Homosapiens

<400>  6994

Met Asn Ala Asp Phe Leu Leu Pro Tyr Tyr Thr Ala Gln Ser Gly Ser 
1               5                   10                  15      


Ser Met Ser Met Phe Asn Thr Thr Met Gly Lys Leu Gln Arg Gln Leu 
            20                  25                  30          


Tyr Lys Gly Glu Tyr Asp Ile Phe Lys Tyr Ala Pro Ile Phe Glu Ser 
        35                  40                  45              


Asp Phe Ile Gln Ile Thr Lys Arg Gly Glu Val Ile Asp Val His Asn 
    50                  55                  60                  


Arg Val Arg Met Val Thr Met Gly Ile Ala Arg Thr Ser Pro Ile Leu 
65                  70                  75                  80  


Pro Leu Pro Asp Val Met Leu Leu Ala Arg Pro Ala Thr Gly Cys Glu 
                85                  90                  95      


Glu Tyr Ala Gly His Gly Gln Ala Thr Lys Arg Lys Lys Arg Lys Ala 
            100                 105                 110         


Ala Lys Asn Leu Glu Leu Thr Arg Leu Leu Pro Leu Arg Phe Val Arg 
        115                 120                 125             


Ile Ser Val Gln Asp His Glu Lys Gln Gln Leu Arg Leu Lys Phe Ala 
    130                 135                 140                 


Thr Gly Arg Ser Cys Tyr Leu Gln Leu Cys Pro Ala Leu Asp Thr Arg 
145                 150                 155                 160 


Asp Asp Leu Phe Ala Tyr Trp Glu Lys Leu Ile Tyr Leu Leu Arg Pro 
                165                 170                 175     


Pro Met Glu Ser Asn Ser Ser Thr Cys Gly Ile Pro Ala Glu Asp Met 
            180                 185                 190         


Met Trp Met Pro Val Phe Gln Glu Asp Arg Arg Ser Leu Gly Ala Val 
        195                 200                 205             


Asn Leu Gln Gly Lys Gly Asp Gln Asp Gln Val Ser Ile Gln Ser Leu 
    210                 215                 220                 


His Met Val Ser Glu Val Cys Gly Ala Thr Ser Ala Ala Tyr Ala Gly 
225                 230                 235                 240 


Gly Glu Gly Leu Gln Asn Asp Phe Asn Lys Pro Thr Asn Val Leu Asn 
                245                 250                 255     


Ala Ser Ile Pro Lys Thr Ser Thr Glu Leu Ala Glu Glu Pro Ala Thr 
            260                 265                 270         


Gly Gly Ile Lys Glu Ala Ala Ala Ala Gly Ala Ala Ala Gly Ala Ala 
        275                 280                 285             


Thr Gly Thr Val Ala Gly Ala Leu Ser Val Ala Ala Ala Asn Ser Ala 
    290                 295                 300                 


Pro Gly Gln Val Ser Ala Ala Ile Ala Gly Ala Ala Thr Ile Gly Ala 
305                 310                 315                 320 


Gly Gly Asn Lys Gly Asn Met Ala Leu Ala Gly Thr Ala Ser Met Ala 
                325                 330                 335     


Pro Asn Ser Thr Lys Val Ala Val Ala Gly Ala Ala Gly Lys Ser Ser 
            340                 345                 350         


Glu His Val Ser Ser Ala Ser Met Ser Leu Ser Arg Glu Gly Ser Val 
        355                 360                 365             


Ser Leu Ala Ile Ala Gly Val Val Leu Thr Ser Arg Thr Ala Ala Glu 
    370                 375                 380                 


Ala Asp Met Asp Ala Ala Ala Gly Pro Pro Val Ser Thr Arg Gln Ser 
385                 390                 395                 400 


Lys Ser Ser Leu Ser Gly Gln His Gly Arg Glu Arg Thr Gln Ala Ser 
                405                 410                 415     


Ala Glu Gly Cys Lys Glu Gly Arg Glu Arg Arg Glu Lys Asp Arg Ala 
            420                 425                 430         


Leu Gly Arg Ser Ser His Arg Arg Arg Thr Gly Glu Ser Arg His Lys 
        435                 440                 445             


Thr Arg Gly Asp Lys Ile Ala Gln Lys Ser Ser Ser Arg Ser Ser Phe 
    450                 455                 460                 


Ser His Arg Ala Asn Arg Asp Asp Lys Lys Glu Lys Gly Cys Gly Asn 
465                 470                 475                 480 


Pro Gly Ser Ser Arg His Arg Asp Ser His Lys Gly Val Ser His Thr 
                485                 490                 495     


Pro Ile Ser Lys Glu Ser Arg Thr Ser His Lys Ser Gly Arg Ser Leu 
            500                 505                 510         


Trp Thr Thr Ser Ser Gly Ser Ser Lys Gly Leu Gly Arg Val Ser Ser 
        515                 520                 525             


Phe Leu Arg Asn Val Arg Ala Asn Leu Thr Thr Lys Val Val Gly Thr 
    530                 535                 540                 


Pro His Gly Arg Asp Val Asn Val Met Ala Lys Met Ala Glu Arg Ser 
545                 550                 555                 560 


Thr Asn Val Ala Ile Ala Glu Thr Ala Glu Gly Gly Gln Gly Leu Glu 
                565                 570                 575     


Thr Val Gly Ser Met Thr Pro Asp Ile Met Glu Thr Val Thr Phe Glu 
            580                 585                 590         


Ala His 
        


<210>  6995
<211>  810
<212>  DNA
<213>  Homosapiens

<400>  6995
atgagtcctt tccatggaaa tcacactgca atgtttgcct cggggagggt ggctgcaggg     60

cccggagtcg cctggatcgc agcgccatct cgtggctgct ggcaggtctg ccttgggccc    120

tcttggcaca aggcaaggaa acaggagctc ttcccatcag tgacagccca ggagaatgct    180

ccagtgtcac cagtgactcc tgctcccaca tctgcctaca ggaagccctc ttggaacaaa    240

agcatctcac ttctgggagg catcaagtat gtgcatcacc agcaggacag acttgcagcg    300

cctattctga gtgaaaaaga gaatcttttg gtgctaccct caaccaacct catcctttct    360

ccacttggat tcttctcaac attgaccctc ttgaaaagat cataaaaact cactttaagg    420

tgtatatgag gagttttgtc tcccaggaag gtttgcattg tatctgtaat ggtggagtct    480

caggcattga cttcccaggt gaaggaaggg tgattttggg atgggggggc cttcctgaaa    540

cctctgaaga aacagcacac cagcacctct gccagccagc tgcatccagg atcaatgttc    600

cccctagttc tggttcactc ttttgaagct ttccaagtcc cagaagtgaa ttcttagcct    660

ttctttgagc tctctttggt ccaggcacag ctgtaggaaa aattgtacag tggcatgaaa    720

aaagtgaagg gtttagtgta gtaaattctg caaattttct tttaaaaaaa actgcatttt    780

aaaaaataaa aatactatgt cctattgtaa                                     810


<210>  6996
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  6996

Met Ser Pro Phe His Gly Asn His Thr Ala Met Phe Ala Ser Gly Arg 
1               5                   10                  15      


Val Ala Ala Gly Pro Gly Val Ala Trp Ile Ala Ala Pro Ser Arg Gly 
            20                  25                  30          


Cys Trp Gln Val Cys Leu Gly Pro Ser Trp His Lys Ala Arg Lys Gln 
        35                  40                  45              


Glu Leu Phe Pro Ser Val Thr Ala Gln Glu Asn Ala Pro Val Ser Pro 
    50                  55                  60                  


Val Thr Pro Ala Pro Thr Ser Ala Tyr Arg Lys Pro Ser Trp Asn Lys 
65                  70                  75                  80  


Ser Ile Ser Leu Leu Gly Gly Ile Lys Tyr Val His His Gln Gln Asp 
                85                  90                  95      


Arg Leu Ala Ala Pro Ile Leu Ser Glu Lys Glu Asn Leu Leu Val Leu 
            100                 105                 110         


Pro Ser Thr Asn Leu Ile Leu Ser Pro Leu Gly Phe Phe Ser Thr Leu 
        115                 120                 125             


Thr Leu Leu Lys Arg Ser 
    130                 


<210>  6997
<211>  605
<212>  DNA
<213>  Homosapiens

<400>  6997
gttctacgcc tctgtaaacc ctgatggaga ggaaactgaa caggaatatg agagcctgga     60

gcaagaaaac accatgctgc ggagagagat cgggaagctg acagaggagc tgaagcacct    120

gacagaggca ctgaaggagc acgagaagat gtgcccgctg ctgctctgcc ctatgaactt    180

tgtgccagtg cctccccggc cggaccctgt ggccggctgc ttgccccgat gaagccgggg    240

acactcctct gcccagcaag gagccttggt cattttcata cctgggagga aggcttttcc    300

ttcacaattg tatacagggg gcacctgtgg ccaggcctcc tcctgggagc tccaggacca    360

gccagctgtg ttccctgcag actgggctca gcccgacatc caacaggcgc caaactcaca    420

gagcccttgt gcagatccag catggaggcc accctcagga gtgacttctc atccaccctg    480

gcagctagta ggttctgctg ttatgcagag ccatttcctc tagaatttgg ataataaaga    540

tgcttattgt ctctcccttc tccagttctg ggaatttaca ggcacaatac acttcctttt    600

cctgg                                                                605


<210>  6998
<211>  101
<212>  PRT
<213>  Homosapiens

<400>  6998

Met Lys Pro Gly Thr Leu Leu Cys Pro Ala Arg Ser Leu Gly His Phe 
1               5                   10                  15      


His Thr Trp Glu Glu Gly Phe Ser Phe Thr Ile Val Tyr Arg Gly His 
            20                  25                  30          


Leu Trp Pro Gly Leu Leu Leu Gly Ala Pro Gly Pro Ala Ser Cys Val 
        35                  40                  45              


Pro Cys Arg Leu Gly Ser Ala Arg His Pro Thr Gly Ala Lys Leu Thr 
    50                  55                  60                  


Glu Pro Leu Cys Arg Ser Ser Met Glu Ala Thr Leu Arg Ser Asp Phe 
65                  70                  75                  80  


Ser Ser Thr Leu Ala Ala Ser Arg Phe Cys Cys Tyr Ala Glu Pro Phe 
                85                  90                  95      


Pro Leu Glu Phe Gly 
            100     


<210>  6999
<211>  2357
<212>  DNA
<213>  Homosapiens

<400>  6999
attaaatgtt tctgctgggt tggcaggtgt gatcatggtg atgagtccag tttagagtca     60

gctccccgag ggcagtatgc aggctgcttt cttgtgctag tgactttttg attacagaga    120

gcaaagaggc atgagaagca ctatgcagaa tacatttttt tttaaagtag caacttcaac    180

aaaggcaggt aacttcttga gggcatactg tatgctggga gctttaggac aaaatctcat    240

ttcatcgcat cccaatccta agcattaggc tgttagcacc aagtctgcag agttcactga    300

ccctttgttt agggcttgta tccccagtgt ctagaacagt gtctggcaca tggtaggtgc    360

tcagttaata catattgaaa gaatgaatga attatgctta caataaatga gaaaactgaa    420

aatttagaga atttaaacca tttacacaag accatgttga cactaagaga caaaactagg    480

atctgtgtga ttctaaagct aaagagctgt cttctaacca catgttcccc tgtaatgttc    540

tggttttgtt tatcaagact tctttgcctc tctagaagac tgtattatca tactttgttc    600

ccttaagctt ctatttgcta tgtatgttat ttattcctct cctttttatg cctttatatt    660

cttgcatatc tgaaacttct tacctgcagt aacttgggaa gatgtgtgtc ttatgtggaa    720

tacaagatga gatcaaatga taactgaaaa tatccttttt tgtgttatta atatttgcat    780

tccgtgaata ttaataactg agtagttttc cttgtttgta cctcttggct cttaaactct    840

gtaagtgtgg tatttttccc gcttggtggt gtcttctcat ggggttctag aaagcaaata    900

ctgctctcct ttttcatgtt ttctatagct gattgaagtg tttttaccat ggtcagtgca    960

tttttccgcc tgcctgtttc atgatcacta ttgagggatt tgactgaatt tggttaaatc   1020

ttacatatag ctaacagctt tcaagacaca taaaaaattt gctgacttct gaaacaaaat   1080

gtcagccaag cattgttcaa atgagtacac tgtcagtggg gtttaagatc atttggtgtg   1140

ttggtagagt tatgtggctg caattagttg taagtgtaat catgatttgc atgcagtatc   1200

aaaagtacct ttcatgtgtg gtggtataag gactggcaaa cagcaagttc cagatagcag   1260

atctctccac cgccccccac ccccacccag ctttccagtc tcagatggac gacattgaca   1320

ccacagctct tccaggcaca cgccctgtgg gctagaggtt tatgaacgtt gatttggaga   1380

ccaacagacc tgagttccac ttcccactca cccacttagt ggctgtaata cctggagcaa   1440

ggtccttaac ctctctgagt ttcttattcc tcatctttta aacggcggtc acaccacaca   1500

cttcacacac tcacatggtg agtgctcctg ggcaaggggc tgttgtgagc ccattggtat   1560

agcaactagt ggtgctgtct actgcaaagc aaatgatgaa gctcagtgaa caacgctgag   1620

tgatgagaca gggcagaaaa gggtaaggcg aggggccacg acatcacacc cacccagtgt   1680

ttttccccag agccctgagg atgatgacag gaaggtccga aggagagaaa aaaaccgagt   1740

tgctgctcag agaagtcgga agaagcagac ccagaaggct gacaagctcc atgaggaata   1800

tgagagcctg gagcaagaaa acaccatgct gcggagagag atcgggaagc tgacagagga   1860

gctgaagcac ctgacagagg cactgaagga gcacgagaag atgtgcccgc tgctgctctg   1920

ccctatgaac tttgtgccag tgcctccccg gccggaccct gtggccggct gcttgccccg   1980

atgaagccgg ggacactcct ctgcccagca aggagccttg gtcattttca tacctgggag   2040

gaaggctttt ccttcacaat tgtatacagg gggcacctgt ggccaggcct cctcctggga   2100

gctccaggac cagccagctg tgttccctgc agactgggct cagcccgaca tccaacaggc   2160

gccaaactca cagagccctt gtgcagatcc agcatggagg ccaccctcag gagtgacttc   2220

tcatccaccc tggcagctag taggttctgc tgttatgcag agccatttcc tctagaattt   2280

ggataataaa gatgcttatt gtctctccct tctccagttc tgggaattta caggcacaat   2340

acacttcctt ttcctgg                                                  2357


<210>  7000
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  7000

Met Met Thr Gly Arg Ser Glu Gly Glu Lys Lys Thr Glu Leu Leu Leu 
1               5                   10                  15      


Arg Glu Val Gly Arg Ser Arg Pro Arg Arg Leu Thr Ser Ser Met Arg 
            20                  25                  30          


Asn Met Arg Ala Trp Ser Lys Lys Thr Pro Cys Cys Gly Glu Arg Ser 
        35                  40                  45              


Gly Ser 
    50  


<210>  7001
<211>  980
<212>  DNA
<213>  Homosapiens

<400>  7001
ggggcagacg tgggacggga aggacggctg ccgggactgg cgcgcgggga cactgggccg     60

acgcgtggag tagcggggag agcgggaagc ctgagggggc ggggccggcg cgaggccgtg    120

ggtgcggcac gaggatgccg gcggcgggac agcgcccgta ggcagcccca cgggcagggc    180

gcgcgggcgg ggcggggcgg gccgggccag aggagcgccc ggcatgtcgc aagggctccc    240

ggccgccggc agcgtcctgc agaggagcgt cgcggcgccc gggaaccagc cgcagccgca    300

gccgcagcag cagagccctg aggatgatga caggaaggtc cgaaggagag aaaaaaaccg    360

agttgctgct cagagaagtc ggaagaagca gacccagaag gctgacaagc tccatgagga    420

atatgagagc ctggagcaag aaaacaccat gctgcggaga gagatcggga agctgacaga    480

ggagctgaag cacctgacag aggcactgaa ggagcacgag aagatgtgcc cgctgctgct    540

ctgccctatg aactttgtgc cagtgcctcc ccggccggac cctgtggccg gctgcttgcc    600

ccgatgaagc cggggacact cctctgccca gcaaggagcc ttggtcattt tcatacctgg    660

gaggaaggct tttccttcac aattgtatac agggggcacc tgtggccagg cctcctcctg    720

ggagctccag gaccagccag ctgtgttccc tgcagactgg gctcagcccg acatccaaca    780

ggcgccaaac tcacagagcc cttgtgcaga tccagcatgg aggccaccct caggagtgac    840

ttctcatcca ccctggcagc tagtaggttc tgctgttatg cagagccatt tcctctagaa    900

tttggataat aaagatgctt attgtctctc ccttctccag ttctgggaat ttacaggcac    960

aatacacttc cttttcctgg                                                980


<210>  7002
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  7002

Met Ser Gln Gly Leu Pro Ala Ala Gly Ser Val Leu Gln Arg Ser Val 
1               5                   10                  15      


Ala Ala Pro Gly Asn Gln Pro Gln Pro Gln Pro Gln Gln Gln Ser Pro 
            20                  25                  30          


Glu Asp Asp Asp Arg Lys Val Arg Arg Arg Glu Lys Asn Arg Val Ala 
        35                  40                  45              


Ala Gln Arg Ser Arg Lys Lys Gln Thr Gln Lys Ala Asp Lys Leu His 
    50                  55                  60                  


Glu Glu Tyr Glu Ser Leu Glu Gln Glu Asn Thr Met Leu Arg Arg Glu 
65                  70                  75                  80  


Ile Gly Lys Leu Thr Glu Glu Leu Lys His Leu Thr Glu Ala Leu Lys 
                85                  90                  95      


Glu His Glu Lys Met Cys Pro Leu Leu Leu Cys Pro Met Asn Phe Val 
            100                 105                 110         


Pro Val Pro Pro Arg Pro Asp Pro Val Ala Gly Cys Leu Pro Arg 
        115                 120                 125         


<210>  7003
<211>  644
<212>  DNA
<213>  Homosapiens

<400>  7003
agaagagcct gatgcaagga actcagagga cctgagatgc tgtatcctaa catttcaaga     60

actgcgatat tgaaaaaagc attggatcta ctagatgtgg ttctattaaa tggaaccaaa    120

cccaacagga atatgagagc ctggagcaag aaaacaccat gctgcggaga gagatcggga    180

agctgacaga ggagctgaag cacctgacag aggcactgaa ggagcacgag aagatgtgcc    240

cgctgctgct ctgccctatg aactttgtgc cagtgcctcc ccggccggac cctgtggccg    300

gctgcttgcc ccgatgaagc cggggacact cctctgccca gcaaggagcc ttggtcattt    360

tcatacctgg gaggaaggct tttccttcac aattgtatac agggggcacc tgtggccagg    420

cctcctcctg ggagctccag gaccagccag ctgtgttccc tgcagactgg gctcagcccg    480

acatccaaca ggcgccaaac tcacagagcc cttgtgcaga tccagcatgg aggccaccct    540

caggagtgac ttctcatcca ccctggcagc tagtaggttc tgctgttatg cagagccatt    600

tcctctagaa tttggataat aaagatgctt attgtctctc cctt                     644


<210>  7004
<211>  49
<212>  PRT
<213>  Homosapiens

<400>  7004

Met Leu Tyr Pro Asn Ile Ser Arg Thr Ala Ile Leu Lys Lys Ala Leu 
1               5                   10                  15      


Asp Leu Leu Asp Val Val Leu Leu Asn Gly Thr Lys Pro Asn Arg Asn 
            20                  25                  30          


Met Arg Ala Trp Ser Lys Lys Thr Pro Cys Cys Gly Glu Arg Ser Gly 
        35                  40                  45              


Ser 
    


<210>  7005
<211>  601
<212>  DNA
<213>  Homosapiens

<400>  7005
cgggctgtgt atgagagtgt gtgagtgtgt ttgcggacgt gtgtgagtgt gtgtatatgt     60

gtatgtgtgt aagagtgtgt gaatgtgtat gagaagcctg gagcaagaaa acaccatgct    120

gcggagagag atcgggaagc tgacagagga gctgaagcac ctgacagagg cactgaagga    180

gcacgagaag atgtgcccgc tgctgctctg ccctatgaac tttgtgccag tgcctccccg    240

gccggaccct gtggccggct gcttgccccg atgaagccgg ggacactcct ctgcccagca    300

aggagccttg gtcattttca tacctgggag gaaggctttt ccttcacaat tgtatacagg    360

gggcacctgt ggccaggcct cctcctggga gctccaggac cagccagctg tgttccctgc    420

agactgggct cagcccgaca tccaacaggc gccaaactca cagagccctt gtgcagatcc    480

agcatggagg ccaccctcag gagtgacttc tcatccaccc tggcagctag taggttctgc    540

tgttatgcag agccatttcc tctagaattt ggataataaa gatgcttatt gtctctccct    600

t                                                                    601


<210>  7006
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  7006

Met Cys Met Arg Ser Leu Glu Gln Glu Asn Thr Met Leu Arg Arg Glu 
1               5                   10                  15      


Ile Gly Lys Leu Thr Glu Glu Leu Lys His Leu Thr Glu Ala Leu Lys 
            20                  25                  30          


Glu His Glu Lys Met Cys Pro Leu Leu Leu Cys Pro Met Asn Phe Val 
        35                  40                  45              


Pro Val Pro Pro Arg Pro Asp Pro Val Ala Gly Cys Leu Pro Arg 
    50                  55                  60              


<210>  7007
<211>  549
<212>  DNA
<213>  Homosapiens

<400>  7007
tacgcctctg taaaccctga tggagaggaa actgaacagg aatatgagag cctggagcaa     60

gaaaacacca tgctgcggag agagatcggg aagctgacag aggagctgaa gcacctgaca    120

gaggcactga aggagcacga gaagatgtgc ccgctgctgc tctgccctat gaactttgtg    180

ccagtgcctc cccggccgga ccctgtggcc ggctgcttgc cccgatgaag ccggggacac    240

tcctctgccc agcaaggagc cttggtcatt ttcatacctg ggaggaaggc ttttccttca    300

caattgtata cagggggcac ctgtggccag gcctcctcct gggagctcca ggaccagcca    360

gctgtgttcc ctgcagactg ggctcagccc gacatccaac aggcgccaaa ctcacagagc    420

ccttgtgcag atccagcatg gaggccaccc tcaggagtga cttctcatcc accctggcag    480

ctagtaggtt ctgctgttat gcagagccat ttcctctaga atttggataa taaagatgct    540

tattgtctc                                                            549


<210>  7008
<211>  101
<212>  PRT
<213>  Homosapiens

<400>  7008

Met Lys Pro Gly Thr Leu Leu Cys Pro Ala Arg Ser Leu Gly His Phe 
1               5                   10                  15      


His Thr Trp Glu Glu Gly Phe Ser Phe Thr Ile Val Tyr Arg Gly His 
            20                  25                  30          


Leu Trp Pro Gly Leu Leu Leu Gly Ala Pro Gly Pro Ala Ser Cys Val 
        35                  40                  45              


Pro Cys Arg Leu Gly Ser Ala Arg His Pro Thr Gly Ala Lys Leu Thr 
    50                  55                  60                  


Glu Pro Leu Cys Arg Ser Ser Met Glu Ala Thr Leu Arg Ser Asp Phe 
65                  70                  75                  80  


Ser Ser Thr Leu Ala Ala Ser Arg Phe Cys Cys Tyr Ala Glu Pro Phe 
                85                  90                  95      


Pro Leu Glu Phe Gly 
            100     


<210>  7009
<211>  923
<212>  DNA
<213>  Homosapiens

<400>  7009
agacgtggga cgggaaggac ggctgccggg actggcgcgc ggggacactg ggccgacgcg     60

tggagtagcg gggagagcgg gaagcctgag ggggcggggc cggcgcgagg ccgtgggtgc    120

ggcacgagga tgccggcggc gggacagcgc ccgtaggcag ccccacgggc agggcgcgcg    180

ggcggggcgg ggcgggccgg gccagaggag cgcccggcat gtcgcaaggg ctcccggccg    240

ccggcagcgt cctgcagagg agcgtcgcgg cgcccgggaa ccagccgcag ccgcagccgc    300

agcagcagag ccctgaggat gatgacagga aggtccgaag gagagaaaaa aaccgagttg    360

ctgctcagag aagtcggaag aagcagaccc agaaggctga caagctccat gaggaatatg    420

agagcctgga gcaagaaaac accatgctgc ggagagagat cgggaagctg acagaggagc    480

tgaagcacct gacagaggca ctgaaggagc acgagaagat gtgcccgctg ctgctctgcc    540

ctatgaactt tgtgccagtg cctccccggc cggaccctgt ggccggctgc ttgccccgat    600

gaagccgggg acactcctct gcccagcaag gagccttggt cattttcata cctgggagga    660

aggcttttcc ttcacaattg tatacagggg gcacctgtgg ccaggcctcc tcctgggagc    720

tccaggacca gccagctgtg ttccctgcag actgggctca gcccgacatc caacaggcgc    780

caaactcaca gagcccttgt gcagatccag catggaggcc accctcagga gtgacttctc    840

atccaccctg gcagctagta ggttctgctg ttatgcagag ccatttcctc tagaatttgg    900

ataataaaga tgcttattgt ctc                                            923


<210>  7010
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  7010

Met Ser Gln Gly Leu Pro Ala Ala Gly Ser Val Leu Gln Arg Ser Val 
1               5                   10                  15      


Ala Ala Pro Gly Asn Gln Pro Gln Pro Gln Pro Gln Gln Gln Ser Pro 
            20                  25                  30          


Glu Asp Asp Asp Arg Lys Val Arg Arg Arg Glu Lys Asn Arg Val Ala 
        35                  40                  45              


Ala Gln Arg Ser Arg Lys Lys Gln Thr Gln Lys Ala Asp Lys Leu His 
    50                  55                  60                  


Glu Glu Tyr Glu Ser Leu Glu Gln Glu Asn Thr Met Leu Arg Arg Glu 
65                  70                  75                  80  


Ile Gly Lys Leu Thr Glu Glu Leu Lys His Leu Thr Glu Ala Leu Lys 
                85                  90                  95      


Glu His Glu Lys Met Cys Pro Leu Leu Leu Cys Pro Met Asn Phe Val 
            100                 105                 110         


Pro Val Pro Pro Arg Pro Asp Pro Val Ala Gly Cys Leu Pro Arg 
        115                 120                 125         


<210>  7011
<211>  1555
<212>  DNA
<213>  Homosapiens

<400>  7011
agagtgcccc gcccacagtt ccgacgaaaa atggcggggt ctcctgagtt ggtggtcctt     60

gaccctccat gggacaagga gctcgcggct ggcacagaga gccaggcctt ggtctccgcc    120

actccccgag aagactttcg ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta    180

caactgtgcg gccgcttcgt gcaaaagctc ggggacgctc tgccggagga gattcgggag    240

cccgctctgc gagatgcgca gtggactttt gaatcagctg tgcaagagaa tatcagcatt    300

aatgggcaag catggcagga agcttcagat aattgtttta tggattctga catcaaagta    360

cttgaagatc agtttgatga aatcatagta gatatagcca caaaacgtaa gcagtatccc    420

agaaagatcc tggaatgtgt catcaaaacc ataaaagcaa aacaagaaat tctgaagcag    480

taccaccctg ttgtacatcc actggaccta aaatatgacc ctgatccagg agccaagcct    540

ggtggactag ctctaggggc agtttaggag agaaggggat cggggaacct tcatcccttc    600

tgcctctggt gaactggcaa gatgaagagg atgaagctgg gtgacccaga gcccgccctc    660

cctctctcgg cagtcatctc caaggccgga gtagactgga ctggagggcc tctgagagga    720

cacagccagg aagcacactc tccctgtgct cttcacccac catgaagaga caggacggga    780

aagtccgtgc tgtgctggtg tccatcagag ggagggacac catccagccc ctgggaccgg    840

gctcggctct gttgttgcac agaagtcatt tggagatccc cacgtgccac atggaggatt    900

gtgggaggac cccaccgagg tggctggcag cctctcatgg acaccatgga gagtgaccca    960

atcactctgc atttgaggac tgcagagtgg ctcagcggtc tggacattga agaggagcca   1020

acctcagggg taacacagtg ccgctgggag ctgagatgag ccaggtggtc ggtgggggac   1080

acaagcctag aacaaattca ataaaccagc cacagacgtt atcatcagat gtgcccagag   1140

acaaggtgga caggggcatt tgctgtggag accagagggc cagagagagt acagggacct   1200

ggatagatgg ctccagcacc tcttcttctc cctacaccca tatgccatct tgataaacag   1260

cagggaaatc tgaaaaatac caagtcttcc catagggaca gtgttacctc ccaaaaactg   1320

tttgaataat tggcttgaac tggattttct gaactgaact aatgctattg ttttgtgggt   1380

ttttttcttc ctactgagta gagtagttgt ttatggggga catctgatcc tttcattttc   1440

ttccagagag ctaaccacct gttctgacac catttattga atagtacctc ttttccccca   1500

ctgatgtgag aggctgcatt tttcatctaa taaaatcgaa tatatattta gatct        1555


<210>  7012
<211>  178
<212>  PRT
<213>  Homosapiens

<400>  7012

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Gly Ala Lys Pro Gly Gly Leu Ala Leu Gly 
                165                 170                 175     


Ala Val 
        


<210>  7013
<211>  315
<212>  DNA
<213>  Homosapiens

<400>  7013
cactgccctt tgcagcacca gctgattaca ttgctttttc catgttctag ctgttctttt     60

gagccgtttt atagccgagc atctccacca gaagagcgga taggaaaaag gaaaagagag    120

gaggatttga ccttggtatc ttgcttcatt tccttctctg acaaaaattt ggtgaaaagg    180

ttaaaataag ttgttacctc ccaaaaactg tttgaataat tggcttgaac tggattttct    240

gaactgaact aatgctattg ttttgtgggt ttttttcttc ctactgagta gagtagttgt    300

ttatggggga catct                                                     315


<210>  7014
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  7014

His Cys Pro Leu Gln His Gln Leu Ile Thr Leu Leu Phe Pro Cys Ser 
1               5                   10                  15      


Ser Cys Ser Phe Glu Pro Phe Tyr Ser Arg Ala Ser Pro Pro Glu Glu 
            20                  25                  30          


Arg Ile Gly Lys Arg Lys Arg Glu Glu Asp Leu Thr Leu Val Ser Cys 
        35                  40                  45              


Phe Ile Ser Phe Ser Asp Lys Asn Leu Val Lys Arg Leu Lys 
    50                  55                  60          


<210>  7015
<211>  2332
<212>  DNA
<213>  Homosapiens

<400>  7015
gacgaaaaat ggcggggtct cctgagttgg tggtccttga ccctccatgg gacaaggagc     60

tcgcggctgg cacagagagc caggccttgg tctccgccac tccccgagaa gactttcggg    120

tgcgctgcac ctcgaagcgg gctgtgaccg aaatgctaca actgtgcggc cgcttcgtgc    180

aaaagctcgg ggacgctctg ccggaggaga ttcgggagcc cgctctgcga gatgcgcagt    240

ggattctgac atcaaagtac ttgaagatca gtttgatgaa atcatagtag atatagccac    300

aaaacgtaag cagtatccca gaaagatcct ggaatgtgtc atcaaaacca taaaagcaaa    360

acaagaaatt ctgaagcagt accaccctgt tgtacatcca ctggacctaa aatatgaccc    420

tgatccagcc cctcatatgg aaaatttgaa atgcagaggg gaaacagtag caaaggagat    480

cagtgaagcc atgaagtcct tgcctgcatt aattgaacaa ggagagggat tttcccaagt    540

tctcaggatg cagcctgtta tccacctcca gaggattcac caagaagtct tttccagttg    600

tcataggaaa ccagatgcta aacctgagaa ctttataaca cagatagaaa ccacaccaac    660

agagactgct tccaggaaaa cctctgacat ggtactgaaa agaaagcaaa ctaaagactg    720

cccccagaga aaatggtatc cattgcggcc aaagaaaatt aatcttgata catgagctct    780

ttctgtttat tttgggagtt gaaaataggc accatcaaca tttagattac agcctaatta    840

atacctagat aagacttcat ttgaaataag aaataactct tttactagtg attcatttat    900

acagatatag tatctctgtg cggggatatg atataatatt gtatttcctt actgttttat    960

ctattgtaaa taaaaagcat tttaaaaagt attgacacaa agcccatcag tgggcattaa   1020

aaatattaaa agtgcagact tttactgtcc ttaagtgcca tcaactctca gctcccttgt   1080

agcttttgtg ggatttaaca agtaacaaat tctgttgtgt ttccctggta tacatctttc   1140

taggaaaaaa aaaaaaaaga gagagagctg tataatgatt tttcgtttac atgctgaaaa   1200

gtaattatca gttctgcaca gcagcagatg cagggttttt ttttaaagat gtagtttgat   1260

ttatcaaatt aatgtgctga tgataatact ggctttgact ttgttactcc atgttcagct   1320

aatttaggtt tgtgagatta actttaggat tttttgttgt gtaagacaat gataactatt   1380

atttgtgcaa cattactctt tgaaataaaa attggcatgt agccaatgtt tcctgcccac   1440

actcactttt ttctatagac cattaacata atttgacttg gaactaatgg tttcttttta   1500

gggtttctta tttatttctt tacaaatcat tccagttcaa aatatatatc agattaatac   1560

actggcaaag tgtcattgtg ttattgaact atttcacatt tgaagatgtt tatatatcag   1620

gtatataatc actgggagaa gtctgagaaa acgatattgg ctttacttct aacatttaac   1680

tatagtttct tatagctctt attgtgtgtc ttacattata cagtgtaggc agggccatca   1740

aacttaccaa ctgtttcccc ttttgatgac tctgatacct tcattcattt ttcaaaggaa   1800

tttactgatc atgaggttgg aaaatctgta tttctcttgc ttattatgta ttaataatca   1860

taaatgtcta gattcaccag aagtcaccag aaggtctgtc tcagtgaaga aaacttataa   1920

agccactttg ttgcattttg tgtttcagtg ttacagtttg agatctgtat atttgtacac   1980

agctatgtgt ttttcattga aataatgtac aaagactgat cttgatgctg tgtattttta   2040

tgagttgtct taggcattcc tgagctcagc ttcagttgga tggtgggtca gcaccctgcg   2100

tttctgaaca tactagactt cagtttaaaa ctgttttgag gctgtataat atgttgctgt   2160

ttttacagtg ctaatgtttt tatagtatta aaattctgta tgatttgttt cacttcagag   2220

gtccccaaac aaaagagtta ttgttaattc tattagatta tataagctac ttgcattttg   2280

attatataag aacatggtcc ctccctttta agagaggtat attgtgctac at           2332


<210>  7016
<211>  242
<212>  PRT
<213>  Homosapiens

<400>  7016

Met Gly Gln Gly Ala Arg Gly Trp His Arg Glu Pro Gly Leu Gly Leu 
1               5                   10                  15      


Arg His Ser Pro Arg Arg Leu Ser Gly Ala Leu His Leu Glu Ala Gly 
            20                  25                  30          


Cys Asp Arg Asn Ala Thr Thr Val Arg Pro Leu Arg Ala Lys Ala Arg 
        35                  40                  45              


Gly Arg Ser Ala Gly Gly Asp Ser Gly Ala Arg Ser Ala Arg Cys Ala 
    50                  55                  60                  


Val Asp Ser Asp Ile Lys Val Leu Glu Asp Gln Phe Asp Glu Ile Ile 
65                  70                  75                  80  


Val Asp Ile Ala Thr Lys Arg Lys Gln Tyr Pro Arg Lys Ile Leu Glu 
                85                  90                  95      


Cys Val Ile Lys Thr Ile Lys Ala Lys Gln Glu Ile Leu Lys Gln Tyr 
            100                 105                 110         


His Pro Val Val His Pro Leu Asp Leu Lys Tyr Asp Pro Asp Pro Ala 
        115                 120                 125             


Pro His Met Glu Asn Leu Lys Cys Arg Gly Glu Thr Val Ala Lys Glu 
    130                 135                 140                 


Ile Ser Glu Ala Met Lys Ser Leu Pro Ala Leu Ile Glu Gln Gly Glu 
145                 150                 155                 160 


Gly Phe Ser Gln Val Leu Arg Met Gln Pro Val Ile His Leu Gln Arg 
                165                 170                 175     


Ile His Gln Glu Val Phe Ser Ser Cys His Arg Lys Pro Asp Ala Lys 
            180                 185                 190         


Pro Glu Asn Phe Ile Thr Gln Ile Glu Thr Thr Pro Thr Glu Thr Ala 
        195                 200                 205             


Ser Arg Lys Thr Ser Asp Met Val Leu Lys Arg Lys Gln Thr Lys Asp 
    210                 215                 220                 


Cys Pro Gln Arg Lys Trp Tyr Pro Leu Arg Pro Lys Lys Ile Asn Leu 
225                 230                 235                 240 


Asp Thr 
        


<210>  7017
<211>  2578
<212>  DNA
<213>  Homosapiens

<400>  7017
ccgacgaaaa atggcggggt ctcctgagtt ggtggtcctt gaccctccat gggacaagga     60

gctcgcggct ggcacagaga gccaggcctt ggtctccgcc actccccgag aagactttcg    120

ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta caactgtgcg gccgcttcgt    180

gcaaaagctc ggggacgctc tgccggagga gattcgggag cccgctctgc gagatgcgca    240

gtgggtacgg gaccagttag ccagttcttt actcatcatc ctcttaccca acacccagga    300

tcttaggatt cagaaagatc ccacgccagg ccttggcaga attaacggtg ccccaggcta    360

ctgtagaacc agttcgagaa acgctagagg agaaagaaat agatgctaat gtcagctggg    420

tcttattaat tacttagacc agcgctgtcc agtgaaaata caagactttt gaatcagctg    480

tgcaagagaa tatcagcatt aatgggcaag catggcagga agcttcagat aattgtttta    540

tggattctga catcaaagta cttgaagatc agtttgatga aatcatagta gatatagcca    600

caaaacgtaa gcagtatccc agaaagatcc tggaatgtgt catcaaaacc ataaaagcaa    660

aacaagaaat tctgcccctc atatggaaaa tttgaaatgc agaggggaaa cagtagcaaa    720

ggagatcagt gaagccatga agtccttgcc tgcattaatt gaacaaggag agggattttc    780

ccaagttctc aggatgcagc ctgttatcca cctccagagg attcaccaag aagtcttttc    840

cagttgtcat aggaaaccag atgctaaacc tgagaacttt ataacacaga tagaaaccac    900

accaacagag actgcttcca ggaaaacctc tgacatggta ctgaaaagaa agcaaactaa    960

agactgcccc cagagaaaat ggtatccatt gcggccaaag aaaattaatc ttgatacatg   1020

agctctttct gtttattttg ggagttgaaa ataggcacca tcaacattta gattacagcc   1080

taattaatac ctagataaga cttcatttga aataagaaat aactctttta ctagtgattc   1140

atttatacag atatagtatc tctgtgcggg gatatgatat aatattgtat ttccttactg   1200

ttttatctat tgtaaataaa aagcatttta aaaagtattg acacaaagcc catcagtggg   1260

cattaaaaat attaaaagtg cagactttta ctgtccttaa gtgccatcaa ctctcagctc   1320

ccttgtagct tttgtgggat ttaacaagta acaaattctg ttgtgtttcc ctggtataca   1380

tctttctagg aaaaaaaaaa aaaagagaga gagctgtata atgatttttc gtttacatgc   1440

tgaaaagtaa ttatcagttc tgcacagcag cagatgcagg gttttttttt aaagatgtag   1500

tttgatttat caaattaatg tgctgatgat aatactggct ttgactttgt tactccatgt   1560

tcagctaatt taggtttgtg agattaactt taggattttt tgttgtgtaa gacaatgata   1620

actattattt gtgcaacatt actctttgaa ataaaaattg gcatgtagcc aatgtttcct   1680

gcccacactc acttttttct atagaccatt aacataattt gacttggaac taatggtttc   1740

tttttagggt ttcttattta tttctttaca aatcattcca gttcaaaata tatatcagat   1800

taatacactg gcaaagtgtc attgtgttat tgaactattt cacatttgaa gatgtttata   1860

tatcaggtat ataatcactg ggagaagtct gagaaaacga tattggcttt acttctaaca   1920

tttaactata gtttcttata gctcttattg tgtgtcttac attatacagt gtaggcaggg   1980

ccatcaaact taccaactgt ttcccctttt gatgactctg ataccttcat tcatttttca   2040

aaggaattta ctgatcatga ggttggaaaa tctgtatttc tcttgcttat tatgtattaa   2100

taatcataaa tgtctagatt caccagaagt caccagaagg tctgtctcag tgaagaaaac   2160

ttataaagcc actttgttgc attttgtgtt tcagtgttac agtttgagat ctgtatattt   2220

gtacacagct atgtgttttt cattgaaata atgtacaaag actgatcttg atgctgtgta   2280

tttttatgag ttgtcttagg cattcctgag ctcagcttca gttggatggt gggtcagcac   2340

cctgcgtttc tgaacatact agacttcagt ttaaaactgt tttgaggctg tataatatgt   2400

tgctgttttt acagtgctaa tgtttttata gtattaaaat tctgtatgat ttgtttcact   2460

tcagaggtcc ccaaacaaaa gagttattgt taattctatt agattatata agctacttgc   2520

attttgatta tataagaaca tggtccctcc cttttaagag aggtatattg tgctacat     2578


<210>  7018
<211>  128
<212>  PRT
<213>  Homosapiens

<400>  7018

Met Cys His Gln Asn His Lys Ser Lys Thr Arg Asn Ser Ala Pro His 
1               5                   10                  15      


Met Glu Asn Leu Lys Cys Arg Gly Glu Thr Val Ala Lys Glu Ile Ser 
            20                  25                  30          


Glu Ala Met Lys Ser Leu Pro Ala Leu Ile Glu Gln Gly Glu Gly Phe 
        35                  40                  45              


Ser Gln Val Leu Arg Met Gln Pro Val Ile His Leu Gln Arg Ile His 
    50                  55                  60                  


Gln Glu Val Phe Ser Ser Cys His Arg Lys Pro Asp Ala Lys Pro Glu 
65                  70                  75                  80  


Asn Phe Ile Thr Gln Ile Glu Thr Thr Pro Thr Glu Thr Ala Ser Arg 
                85                  90                  95      


Lys Thr Ser Asp Met Val Leu Lys Arg Lys Gln Thr Lys Asp Cys Pro 
            100                 105                 110         


Gln Arg Lys Trp Tyr Pro Leu Arg Pro Lys Lys Ile Asn Leu Asp Thr 
        115                 120                 125             


<210>  7019
<211>  2071
<212>  DNA
<213>  Homosapiens

<400>  7019
tccgacgaaa aatggcgggg tctcctgagt tggtggtcct tgaccctcca tgggacaagg     60

agctcgcggc tggcacagag agccaggcct tggtctccgc cactccccga gaagactttc    120

gggtgcgctg cacctcgaag cgggctgtga ccgaaatgct acaactgtgc ggccgcttcg    180

tgcaaaagct cggggacgct ctgccggagg agattcggga gcccgctctg cgagatgcgc    240

agtggacttt tgaatcagct gtgcaagaga atatcagcat taatgggcaa gcatggcagg    300

aagcttcaga taattgtttt atggattctg acatcaaagt acttgaagat cagtttgatg    360

aaatcatagt agatatacac agatagaaac cacaccaaca gagactgctt ccaggaaaac    420

ctctgacatg gtactgaaaa gaaagcaaac taaagactgc ccccagagaa aatggtatcc    480

attgcggcca aagaaaatta atcttgatac atgagctctt tctgtttatt ttgggagttg    540

aaaataggca ccatcaacat ttagattaca gcctaattaa tacctagata agacttcatt    600

tgaaataaga aataactctt ttactagtga ttcatttata cagatatagt atctctgtgc    660

ggggatatga tataatattg tatttcctta ctgttttatc tattgtaaat aaaaagcatt    720

ttaaaaagta ttgacacaaa gcccatcagt gggcattaaa aatattaaaa gtgcagactt    780

ttactgtcct taagtgccat caactctcag ctcccttgta gcttttgtgg gatttaacaa    840

gtaacaaatt ctgttgtgtt tccctggtat acatctttct aggaaaaaaa aaaaaaagag    900

agagagctgt ataatgattt ttcgtttaca tgctgaaaag taattatcag ttctgcacag    960

cagcagatgc agggtttttt tttaaagatg tagtttgatt tatcaaatta atgtgctgat   1020

gataatactg gctttgactt tgttactcca tgttcagcta atttaggttt gtgagattaa   1080

ctttaggatt ttttgttgtg taagacaatg ataactatta tttgtgcaac attactcttt   1140

gaaataaaaa ttggcatgta gccaatgttt cctgcccaca ctcacttttt tctatagacc   1200

attaacataa tttgacttgg aactaatggt ttctttttag ggtttcttat ttatttcttt   1260

acaaatcatt ccagttcaaa atatatatca gattaataca ctggcaaagt gtcattgtgt   1320

tattgaacta tttcacattt gaagatgttt atatatcagg tatataatca ctgggagaag   1380

tctgagaaaa cgatattggc tttacttcta acatttaact atagtttctt atagctctta   1440

ttgtgtgtct tacattatac agtgtaggca gggccatcaa acttaccaac tgtttcccct   1500

tttgatgact ctgatacctt cattcatttt tcaaaggaat ttactgatca tgaggttgga   1560

aaatctgtat ttctcttgct tattatgtat taataatcat aaatgtctag attcaccaga   1620

agtcaccaga aggtctgtct cagtgaagaa aacttataaa gccactttgt tgcattttgt   1680

gtttcagtgt tacagtttga gatctgtata tttgtacaca gctatgtgtt tttcattgaa   1740

ataatgtaca aagactgatc ttgatgctgt gtatttttat gagttgtctt aggcattcct   1800

gagctcagct tcagttggat ggtgggtcag caccctgcgt ttctgaacat actagacttc   1860

agtttaaaac tgttttgagg ctgtataata tgttgctgtt tttacagtgc taatgttttt   1920

atagtattaa aattctgtat gatttgtttc acttcagagg tccccaaaca aaagagttat   1980

tgttaattct attagattat ataagctact tgcattttga ttatataaga acatggtccc   2040

tcccttttaa gagaggtata ttgtgctaca t                                  2071


<210>  7020
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  7020

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile His Arg 
        115                 120                 


<210>  7021
<211>  2296
<212>  DNA
<213>  Homosapiens

<400>  7021
acagttccga cgaaaaatgg cggggtctcc tgagttggtg gtccttgacc ctccatggga     60

caaggagctc gcggctggca cagagagcca ggccttggtc tccgccactc cccgagaaga    120

ctttcgggtg cgctgcacct cgaagcgggc tgtgaccgaa atgctacaac tgtgcggccg    180

cttcgtgcaa aagctcgggg acgctctgcc ggaggagatt cgggagcccg ctctgcgaga    240

tgcgcagtgg acttttgaat cagctgtgca agagaatatc agcattaatg ggcaagcatg    300

gcaggaagct tcagataatt gttttatgga ttctgacatc aaagtacttg aagatcagtt    360

tgatgaaatc atagtagata tagccacaaa acgtaagcag tatcccagaa agatcctgga    420

atgtgtcatc aaaaccataa aagcaaaaca agaaattctg tccttgcctg cattaattga    480

acaaggagag ggattttccc aagttctcag gatgcagcct gttatccacc tccagaggat    540

tcaccaagaa gtcttttcca gttgtcatag gaaaccagat gctaaacctg agaactttat    600

aacacagata gaaaccacac caacagagac tgcttccagg aaaacctctg acatggtact    660

gaaaagaaag caaactaaag actgccccca gagaaaatgg tatccattgc ggccaaagaa    720

aattaatctt gatacatgag ctctttctgt ttattttggg agttgaaaat aggcaccatc    780

aacatttaga ttacagccta attaatacct agataagact tcatttgaaa taagaaataa    840

ctcttttact agtgattcat ttatacagat atagtatctc tgtgcgggga tatgatataa    900

tattgtattt ccttactgtt ttatctattg taaataaaaa gcattttaaa aagtattgac    960

acaaagccca tcagtgggca ttaaaaatat taaaagtgca gacttttact gtccttaagt   1020

gccatcaact ctcagctccc ttgtagcttt tgtgggattt aacaagtaac aaattctgtt   1080

gtgtttccct ggtatacatc tttctaggaa aaaaaaaaaa aagagagaga gctgtataat   1140

gatttttcgt ttacatgctg aaaagtaatt atcagttctg cacagcagca gatgcagggt   1200

ttttttttaa agatgtagtt tgatttatca aattaatgtg ctgatgataa tactggcttt   1260

gactttgtta ctccatgttc agctaattta ggtttgtgag attaacttta ggattttttg   1320

ttgtgtaaga caatgataac tattatttgt gcaacattac tctttgaaat aaaaattggc   1380

atgtagccaa tgtttcctgc ccacactcac ttttttctat agaccattaa cataatttga   1440

cttggaacta atggtttctt tttagggttt cttatttatt tctttacaaa tcattccagt   1500

tcaaaatata tatcagatta atacactggc aaagtgtcat tgtgttattg aactatttca   1560

catttgaaga tgtttatata tcaggtatat aatcactggg agaagtctga gaaaacgata   1620

ttggctttac ttctaacatt taactatagt ttcttatagc tcttattgtg tgtcttacat   1680

tatacagtgt aggcagggcc atcaaactta ccaactgttt ccccttttga tgactctgat   1740

accttcattc atttttcaaa ggaatttact gatcatgagg ttggaaaatc tgtatttctc   1800

ttgcttatta tgtattaata atcataaatg tctagattca ccagaagtca ccagaaggtc   1860

tgtctcagtg aagaaaactt ataaagccac tttgttgcat tttgtgtttc agtgttacag   1920

tttgagatct gtatatttgt acacagctat gtgtttttca ttgaaataat gtacaaagac   1980

tgatcttgat gctgtgtatt tttatgagtt gtcttaggca ttcctgagct cagcttcagt   2040

tggatggtgg gtcagcaccc tgcgtttctg aacatactag acttcagttt aaaactgttt   2100

tgaggctgta taatatgttg ctgtttttac agtgctaatg tttttatagt attaaaattc   2160

tgtatgattt gtttcacttc agaggtcccc aaacaaaaga gttattgtta attctattag   2220

attatataag ctacttgcat tttgattata taagaacatg gtccctccct tttaagagag   2280

gtatattgtg ctacat                                                   2296


<210>  7022
<211>  240
<212>  PRT
<213>  Homosapiens

<400>  7022

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Ser Leu Pro Ala Leu Ile Glu Gln Gly Glu Gly Phe 
145                 150                 155                 160 


Ser Gln Val Leu Arg Met Gln Pro Val Ile His Leu Gln Arg Ile His 
                165                 170                 175     


Gln Glu Val Phe Ser Ser Cys His Arg Lys Pro Asp Ala Lys Pro Glu 
            180                 185                 190         


Asn Phe Ile Thr Gln Ile Glu Thr Thr Pro Thr Glu Thr Ala Ser Arg 
        195                 200                 205             


Lys Thr Ser Asp Met Val Leu Lys Arg Lys Gln Thr Lys Asp Cys Pro 
    210                 215                 220                 


Gln Arg Lys Trp Tyr Pro Leu Arg Pro Lys Lys Ile Asn Leu Asp Thr 
225                 230                 235                 240 


<210>  7023
<211>  2368
<212>  DNA
<213>  Homosapiens

<400>  7023
gcccacagtt ccgacgaaaa atggcggggt ctcctgagtt ggtggtcctt gaccctccat     60

gggacaagga gctcgcggct ggcacagaga gccaggcctt ggtctccgcc actccccgag    120

aagactttcg ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta caactgtgcg    180

gccgcttcgt gcaaaagctc ggggacgctc tgccggagga gattcgggag cccgctctgc    240

gagatgcgca gtggactttt gaatcagctg tgcaagagaa tatcagcatt aatgggcaag    300

catggcagga agcttcagat aattgtttta tggattctga catcaaagta cttgaagatc    360

agtttgatga aatcatagta gatatagcca caaaacgtaa gcagtatccc agaaagatcc    420

tggaatgtgt catcaaaacc ataaaagcaa aacaagaaat tctgcccctc atatggaaaa    480

tttgaaatgc agaggggaaa cagtagcaaa ggagatcagt gaagccatga agtccttgcc    540

tgcattaatt gaacaaggag agggattttc ccaagttctc aggatgcagc ctgttatcca    600

cctccagagg attcaccaag aagtcttttc cagttgtcat aggaaaccag atgctaaacc    660

tgagaacttt ataacacaga tagaaaccac accaacagag actgcttcca ggaaaacctc    720

tgacatggta ctgaaaagaa agcaaactaa agactgcccc cagagaaaat ggtatccatt    780

gcggccaaag aaaattaatc ttgatacatg agctctttct gtttattttg ggagttgaaa    840

ataggcacca tcaacattta gattacagcc taattaatac ctagataaga cttcatttga    900

aataagaaat aactctttta ctagtgattc atttatacag atatagtatc tctgtgcggg    960

gatatgatat aatattgtat ttccttactg ttttatctat tgtaaataaa aagcatttta   1020

aaaagtattg acacaaagcc catcagtggg cattaaaaat attaaaagtg cagactttta   1080

ctgtccttaa gtgccatcaa ctctcagctc ccttgtagct tttgtgggat ttaacaagta   1140

acaaattctg ttgtgtttcc ctggtataca tctttctagg aaaaaaaaaa aaaagagaga   1200

gagctgtata atgatttttc gtttacatgc tgaaaagtaa ttatcagttc tgcacagcag   1260

cagatgcagg gttttttttt aaagatgtag tttgatttat caaattaatg tgctgatgat   1320

aatactggct ttgactttgt tactccatgt tcagctaatt taggtttgtg agattaactt   1380

taggattttt tgttgtgtaa gacaatgata actattattt gtgcaacatt actctttgaa   1440

ataaaaattg gcatgtagcc aatgtttcct gcccacactc acttttttct atagaccatt   1500

aacataattt gacttggaac taatggtttc tttttagggt ttcttattta tttctttaca   1560

aatcattcca gttcaaaata tatatcagat taatacactg gcaaagtgtc attgtgttat   1620

tgaactattt cacatttgaa gatgtttata tatcaggtat ataatcactg ggagaagtct   1680

gagaaaacga tattggcttt acttctaaca tttaactata gtttcttata gctcttattg   1740

tgtgtcttac attatacagt gtaggcaggg ccatcaaact taccaactgt ttcccctttt   1800

gatgactctg ataccttcat tcatttttca aaggaattta ctgatcatga ggttggaaaa   1860

tctgtatttc tcttgcttat tatgtattaa taatcataaa tgtctagatt caccagaagt   1920

caccagaagg tctgtctcag tgaagaaaac ttataaagcc actttgttgc attttgtgtt   1980

tcagtgttac agtttgagat ctgtatattt gtacacagct atgtgttttt cattgaaata   2040

atgtacaaag actgatcttg atgctgtgta tttttatgag ttgtcttagg cattcctgag   2100

ctcagcttca gttggatggt gggtcagcac cctgcgtttc tgaacatact agacttcagt   2160

ttaaaactgt tttgaggctg tataatatgt tgctgttttt acagtgctaa tgtttttata   2220

gtattaaaat tctgtatgat ttgtttcact tcagaggtcc ccaaacaaaa gagttattgt   2280

taattctatt agattatata agctacttgc attttgatta tataagaaca tggtccctcc   2340

cttttaagag aggtatattg tgctacat                                      2368


<210>  7024
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  7024

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Pro Leu Ile Trp Lys Ile 
145                 150                 


<210>  7025
<211>  2518
<212>  DNA
<213>  Homosapiens

<400>  7025
agagtgcccc gcccacagtt ccgacgaaaa atggcggggt ctcctgagtt ggtggtcctt     60

gaccctccat gggacaagga gctcgcggct ggcacagaga gccaggcctt ggtctccgcc    120

actccccgag aagactttcg ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta    180

caactgtgcg gccgcttcgt gcaaaagctc ggggacgctc tgccggagga gattcgggag    240

cccgctctgc gagatgcgca gtggactttt gaatcagctg tgcaagagaa tatcagcatt    300

aatgggcaag catggcagga agcttcagat aattgtttta tggattctga catcaaagta    360

cttgaagatc agtttgatga aatcatagta gatatagcca caaaacgtaa gcagtatccc    420

agaaagatcc tggaatgtgt catcaaaacc ataaaagcaa aacaagaaat tctgaagcag    480

taccaccctg ttgtacatcc actggaccta aaatatgacc ctgatccagt tctcaacggg    540

aatgctttca acttttcccc attcaacatg atgttggctg tggatttgtc atatatggtt    600

tttattactt cgagcccctc atatggaaaa tttgaaatgc agaggggaaa cagtagcaaa    660

ggagatcagt gaagccatga agtccttgcc tgcattaatt gaacaaggag agggattttc    720

ccaagttctc aggatgcagc ctgttatcca cctccagagg attcaccaag aagtcttttc    780

cagttgtcat aggaaaccag atgctaaacc tgagaacttt ataacacaga tagaaaccac    840

accaacagag actgcttcca ggaaaacctc tgacatggta ctgaaaagaa agcaaactaa    900

agactgcccc cagagaaaat ggtatccatt gcggccaaag aaaattaatc ttgatacatg    960

agctctttct gtttattttg ggagttgaaa ataggcacca tcaacattta gattacagcc   1020

taattaatac ctagataaga cttcatttga aataagaaat aactctttta ctagtgattc   1080

atttatacag atatagtatc tctgtgcggg gatatgatat aatattgtat ttccttactg   1140

ttttatctat tgtaaataaa aagcatttta aaaagtattg acacaaagcc catcagtggg   1200

cattaaaaat attaaaagtg cagactttta ctgtccttaa gtgccatcaa ctctcagctc   1260

ccttgtagct tttgtgggat ttaacaagta acaaattctg ttgtgtttcc ctggtataca   1320

tctttctagg aaaaaaaaaa aaaagagaga gagctgtata atgatttttc gtttacatgc   1380

tgaaaagtaa ttatcagttc tgcacagcag cagatgcagg gttttttttt aaagatgtag   1440

tttgatttat caaattaatg tgctgatgat aatactggct ttgactttgt tactccatgt   1500

tcagctaatt taggtttgtg agattaactt taggattttt tgttgtgtaa gacaatgata   1560

actattattt gtgcaacatt actctttgaa ataaaaattg gcatgtagcc aatgtttcct   1620

gcccacactc acttttttct atagaccatt aacataattt gacttggaac taatggtttc   1680

tttttagggt ttcttattta tttctttaca aatcattcca gttcaaaata tatatcagat   1740

taatacactg gcaaagtgtc attgtgttat tgaactattt cacatttgaa gatgtttata   1800

tatcaggtat ataatcactg ggagaagtct gagaaaacga tattggcttt acttctaaca   1860

tttaactata gtttcttata gctcttattg tgtgtcttac attatacagt gtaggcaggg   1920

ccatcaaact taccaactgt ttcccctttt gatgactctg ataccttcat tcatttttca   1980

aaggaattta ctgatcatga ggttggaaaa tctgtatttc tcttgcttat tatgtattaa   2040

taatcataaa tgtctagatt caccagaagt caccagaagg tctgtctcag tgaagaaaac   2100

ttataaagcc actttgttgc attttgtgtt tcagtgttac agtttgagat ctgtatattt   2160

gtacacagct atgtgttttt cattgaaata atgtacaaag actgatcttg atgctgtgta   2220

tttttatgag ttgtcttagg cattcctgag ctcagcttca gttggatggt gggtcagcac   2280

cctgcgtttc tgaacatact agacttcagt ttaaaactgt tttgaggctg tataatatgt   2340

tgctgttttt acagtgctaa tgtttttata gtattaaaat tctgtatgat ttgtttcact   2400

tcagaggtcc ccaaacaaaa gagttattgt taattctatt agattatata agctacttgc   2460

attttgatta tataagaaca tggtccctcc cttttaagag aggtatattg tgctacat     2518


<210>  7026
<211>  213
<212>  PRT
<213>  Homosapiens

<400>  7026

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Val Leu Asn Gly Asn Ala Phe Asn Phe Ser 
                165                 170                 175     


Pro Phe Asn Met Met Leu Ala Val Asp Leu Ser Tyr Met Val Phe Ile 
            180                 185                 190         


Thr Ser Ser Pro Ser Tyr Gly Lys Phe Glu Met Gln Arg Gly Asn Ser 
        195                 200                 205             


Ser Lys Gly Asp Gln 
    210             


<210>  7027
<211>  2365
<212>  DNA
<213>  Homosapiens

<400>  7027
agagtgcccc gcccacagtt ccgacgaaaa atggcggggt ctcctgagtt ggtggtcctt     60

gaccctccat gggacaagga gctcgcggct ggcacagaga gccaggcctt ggtctccgcc    120

actccccgag aagactttcg ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta    180

caactgtgcg gccgcttcgt gcaaaagctc ggggacgctc tgccggagga gattcgggag    240

cccgctctgc gagatgcgca gtggactttt gaatcagctg tgcaagagaa tatcagcatt    300

aatgggcaag catggcagga agcttcagat aattgtttta tggattctga catcaaagta    360

cttgaagatc agtttgatga aatcatagta gatatagcca caaaacgtaa gcagtatccc    420

agaaagatcc tggaatgtgt catcaaaacc ataaaagcaa aacaagaaat tctgaagcag    480

taccaccctg ttgtacatcc actggaccta aaatatgacc ctgatccagt ccttgcctgc    540

attaattgaa caaggagagg gattttccca agttctcagg atgcagcctg ttatccacct    600

ccagaggatt caccaagaag tcttttccag ttgtcatagg aaaccagatg ctaaacctga    660

gaactttata acacagatag aaaccacacc aacagagact gcttccagga aaacctctga    720

catggtactg aaaagaaagc aaactaaaga ctgcccccag agaaaatggt atccattgcg    780

gccaaagaaa attaatcttg atacatgagc tctttctgtt tattttggga gttgaaaata    840

ggcaccatca acatttagat tacagcctaa ttaataccta gataagactt catttgaaat    900

aagaaataac tcttttacta gtgattcatt tatacagata tagtatctct gtgcggggat    960

atgatataat attgtatttc cttactgttt tatctattgt aaataaaaag cattttaaaa   1020

agtattgaca caaagcccat cagtgggcat taaaaatatt aaaagtgcag acttttactg   1080

tccttaagtg ccatcaactc tcagctccct tgtagctttt gtgggattta acaagtaaca   1140

aattctgttg tgtttccctg gtatacatct ttctaggaaa aaaaaaaaaa agagagagag   1200

ctgtataatg atttttcgtt tacatgctga aaagtaatta tcagttctgc acagcagcag   1260

atgcagggtt tttttttaaa gatgtagttt gatttatcaa attaatgtgc tgatgataat   1320

actggctttg actttgttac tccatgttca gctaatttag gtttgtgaga ttaactttag   1380

gattttttgt tgtgtaagac aatgataact attatttgtg caacattact ctttgaaata   1440

aaaattggca tgtagccaat gtttcctgcc cacactcact tttttctata gaccattaac   1500

ataatttgac ttggaactaa tggtttcttt ttagggtttc ttatttattt ctttacaaat   1560

cattccagtt caaaatatat atcagattaa tacactggca aagtgtcatt gtgttattga   1620

actatttcac atttgaagat gtttatatat caggtatata atcactggga gaagtctgag   1680

aaaacgatat tggctttact tctaacattt aactatagtt tcttatagct cttattgtgt   1740

gtcttacatt atacagtgta ggcagggcca tcaaacttac caactgtttc cccttttgat   1800

gactctgata ccttcattca tttttcaaag gaatttactg atcatgaggt tggaaaatct   1860

gtatttctct tgcttattat gtattaataa tcataaatgt ctagattcac cagaagtcac   1920

cagaaggtct gtctcagtga agaaaactta taaagccact ttgttgcatt ttgtgtttca   1980

gtgttacagt ttgagatctg tatatttgta cacagctatg tgtttttcat tgaaataatg   2040

tacaaagact gatcttgatg ctgtgtattt ttatgagttg tcttaggcat tcctgagctc   2100

agcttcagtt ggatggtggg tcagcaccct gcgtttctga acatactaga cttcagttta   2160

aaactgtttt gaggctgtat aatatgttgc tgtttttaca gtgctaatgt ttttatagta   2220

ttaaaattct gtatgatttg tttcacttca gaggtcccca aacaaaagag ttattgttaa   2280

ttctattaga ttatataagc tacttgcatt ttgattatat aagaacatgg tccctccctt   2340

ttaagagagg tatattgtgc tacat                                         2365


<210>  7028
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  7028

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Val Leu Ala Cys Ile Asn 
                165                 170         


<210>  7029
<211>  2433
<212>  DNA
<213>  Homosapiens

<400>  7029
agagtgcccc gcccacagtt ccgacgaaaa atggcggggt ctcctgagtt ggtggtcctt     60

gaccctccat gggacaagga gctcgcggct ggcacagaga gccaggcctt ggtctccgcc    120

actccccgag aagactttcg ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta    180

caactgtgcg gccgcttcgt gcaaaagctc ggggacgctc tgccggagga gattcgggag    240

cccgctctgc gagatgcgca gtggactttt gaatcagctg tgcaagagaa tatcagcatt    300

aatgggcaag catggcagga agcttcagat aattgtttta tggattctga catcaaagta    360

cttgaagatc agtttgatga aatcatagta gatatagcca caaaacgtaa gcagtatccc    420

agaaagatcc tggaatgtgt catcaaaacc ataaaagcaa aacaagaaat tctgaagcag    480

taccaccctg ttgtacatcc actggaccta aaatatgacc ctgatccagc ccctcatatg    540

gaaaatttga aatgcagagg ggaaacagta gcaaaggaga tcagtgaagc catgaagtcc    600

ttgcctgcat taattgaaca aggagaggga ttttcccaag ttctcaggat gcagcctgtt    660

atccacctcc agaggattca ccaagaagtc ttttccagtt gtcataggaa accagatgct    720

aaacctgaga actttataac acagatagaa accacaccaa cagagactgc ttccaggaaa    780

acctctgaca tggtactgaa aagaaagcaa actaaagact gcccccagag aaaatggtat    840

ccattgcggc caaagaaaat taatcttgat acatgagctc tttctgttta ttttgggagt    900

tgaaaatagg caccatcaac atttagatta cagcctaatt aatacctaga taagacttca    960

tttgaaataa gaaataactc ttttactagt gattcattta tacagatata gtatctctgt   1020

gcggggatat gatataatat tgtatttcct tactgtttta tctattgtaa ataaaaagca   1080

ttttaaaaag tattgacaca aagcccatca gtgggcatta aaaatattaa aagtgcagac   1140

ttttactgtc cttaagtgcc atcaactctc agctcccttg tagcttttgt gggatttaac   1200

aagtaacaaa ttctgttgtg tttccctggt atacatcttt ctaggaaaaa aaaaaaaaag   1260

agagagagct gtataatgat ttttcgttta catgctgaaa agtaattatc agttctgcac   1320

agcagcagat gcagggtttt tttttaaaga tgtagtttga tttatcaaat taatgtgctg   1380

atgataatac tggctttgac tttgttactc catgttcagc taatttaggt ttgtgagatt   1440

aactttagga ttttttgttg tgtaagacaa tgataactat tatttgtgca acattactct   1500

ttgaaataaa aattggcatg tagccaatgt ttcctgccca cactcacttt tttctataga   1560

ccattaacat aatttgactt ggaactaatg gtttcttttt agggtttctt atttatttct   1620

ttacaaatca ttccagttca aaatatatat cagattaata cactggcaaa gtgtcattgt   1680

gttattgaac tatttcacat ttgaagatgt ttatatatca ggtatataat cactgggaga   1740

agtctgagaa aacgatattg gctttacttc taacatttaa ctatagtttc ttatagctct   1800

tattgtgtgt cttacattat acagtgtagg cagggccatc aaacttacca actgtttccc   1860

cttttgatga ctctgatacc ttcattcatt tttcaaagga atttactgat catgaggttg   1920

gaaaatctgt atttctcttg cttattatgt attaataatc ataaatgtct agattcacca   1980

gaagtcacca gaaggtctgt ctcagtgaag aaaacttata aagccacttt gttgcatttt   2040

gtgtttcagt gttacagttt gagatctgta tatttgtaca cagctatgtg tttttcattg   2100

aaataatgta caaagactga tcttgatgct gtgtattttt atgagttgtc ttaggcattc   2160

ctgagctcag cttcagttgg atggtgggtc agcaccctgc gtttctgaac atactagact   2220

tcagtttaaa actgttttga ggctgtataa tatgttgctg tttttacagt gctaatgttt   2280

ttatagtatt aaaattctgt atgatttgtt tcacttcaga ggtccccaaa caaaagagtt   2340

attgttaatt ctattagatt atataagcta cttgcatttt gattatataa gaacatggtc   2400

cctccctttt aagagaggta tattgtgcta cat                                2433


<210>  7030
<211>  281
<212>  PRT
<213>  Homosapiens

<400>  7030

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Ala Pro His Met Glu Asn Leu Lys Cys Arg 
                165                 170                 175     


Gly Glu Thr Val Ala Lys Glu Ile Ser Glu Ala Met Lys Ser Leu Pro 
            180                 185                 190         


Ala Leu Ile Glu Gln Gly Glu Gly Phe Ser Gln Val Leu Arg Met Gln 
        195                 200                 205             


Pro Val Ile His Leu Gln Arg Ile His Gln Glu Val Phe Ser Ser Cys 
    210                 215                 220                 


His Arg Lys Pro Asp Ala Lys Pro Glu Asn Phe Ile Thr Gln Ile Glu 
225                 230                 235                 240 


Thr Thr Pro Thr Glu Thr Ala Ser Arg Lys Thr Ser Asp Met Val Leu 
                245                 250                 255     


Lys Arg Lys Gln Thr Lys Asp Cys Pro Gln Arg Lys Trp Tyr Pro Leu 
            260                 265                 270         


Arg Pro Lys Lys Ile Asn Leu Asp Thr 
        275                 280     


<210>  7031
<211>  1440
<212>  DNA
<213>  Homosapiens

<400>  7031
gacgaaaaat ggcggggtct cctgagttgg tggtccttga ccctccatgg gacaaggagc     60

tcgcggctgg cacagagagc caggccttgg tctccgccac tccccgagaa gactttcggg    120

tgcgctgcac ctcgaagcgg gctgtgaccg aaatgctaca actgtgcggc cgcttcgtgc    180

aaaagctcgg ggacgctctg ccggaggaga ttcgggagcc cgctctgcga gatgcgcagt    240

ggattctgac atcaaagtac ttgaagatca gtttgatgaa atcatagtag atatagccac    300

aaaacgtaag cagtatccca gaaagatcct ggaatgtgtc atcaaaacca taaaagcaaa    360

acaagaaatt ctgaagcagt accaccctgt tgtacatcca ctggacctaa aatatgaccc    420

tgatccagcc cctcatatgg aaaatttgaa atgcagaggg gaaacagtag caaaggagat    480

cagtgaagcc atgaagtcct tgcctgcatt aattgaacaa ggagagggat tttcccaagt    540

tctcaggatg cagcctgtta tccacctcca gaggattcac caagaagtct tttccagttg    600

tcataggaaa ccagatgcta aacctgagaa ctttataaca cagatagaaa ccacaccaac    660

agagactgct tccaggaaaa cctctgacat ggtactgaaa agaaagcaaa ctaaagactg    720

cccccagaga aaatggtatc cattgcggcc aaagaaaatt aatcttgata catgagctct    780

ttctgtttat tttgggagtt gaaaataggc accatcaaca tttagattac agcctaatta    840

atacctagat aagacttcat ttgaaataag aaataactct tttactagtg attcatttat    900

acagatatag tatctctgtg cggggatatg atataatatt gtatttcctt actgttttat    960

ctattgtaaa taaaaagcat tttaaaaagt attgacacaa agcccatcag tgggcattaa   1020

aaatattaaa agtgcagact tttactgtcc ttaagtgcca tcaactctca gctcccttgt   1080

agcttttgtg ggatttaaca agtaacaaat tctgttgtgt ttccctggta tacatctttc   1140

taggaaaaaa aaaaaaaaga gagagagctg tataatgatt tttcgtttac atgctgaaaa   1200

gtaattatca gttctgcaca gcagcagatg cagggttttt ttttaaagat gtagtttgat   1260

ttatcaaatt aatgtgctga tgataatact ggctttgact ttgttactcc atgttcagct   1320

aatttaggtt tgtgagatta actttaggat tttttgttgt gtaagacaat gataactatt   1380

atttgtgcaa cattactctt tgaaataaaa attggcatgt agccaatgtt tcctgcccac   1440


<210>  7032
<211>  242
<212>  PRT
<213>  Homosapiens

<400>  7032

Met Gly Gln Gly Ala Arg Gly Trp His Arg Glu Pro Gly Leu Gly Leu 
1               5                   10                  15      


Arg His Ser Pro Arg Arg Leu Ser Gly Ala Leu His Leu Glu Ala Gly 
            20                  25                  30          


Cys Asp Arg Asn Ala Thr Thr Val Arg Pro Leu Arg Ala Lys Ala Arg 
        35                  40                  45              


Gly Arg Ser Ala Gly Gly Asp Ser Gly Ala Arg Ser Ala Arg Cys Ala 
    50                  55                  60                  


Val Asp Ser Asp Ile Lys Val Leu Glu Asp Gln Phe Asp Glu Ile Ile 
65                  70                  75                  80  


Val Asp Ile Ala Thr Lys Arg Lys Gln Tyr Pro Arg Lys Ile Leu Glu 
                85                  90                  95      


Cys Val Ile Lys Thr Ile Lys Ala Lys Gln Glu Ile Leu Lys Gln Tyr 
            100                 105                 110         


His Pro Val Val His Pro Leu Asp Leu Lys Tyr Asp Pro Asp Pro Ala 
        115                 120                 125             


Pro His Met Glu Asn Leu Lys Cys Arg Gly Glu Thr Val Ala Lys Glu 
    130                 135                 140                 


Ile Ser Glu Ala Met Lys Ser Leu Pro Ala Leu Ile Glu Gln Gly Glu 
145                 150                 155                 160 


Gly Phe Ser Gln Val Leu Arg Met Gln Pro Val Ile His Leu Gln Arg 
                165                 170                 175     


Ile His Gln Glu Val Phe Ser Ser Cys His Arg Lys Pro Asp Ala Lys 
            180                 185                 190         


Pro Glu Asn Phe Ile Thr Gln Ile Glu Thr Thr Pro Thr Glu Thr Ala 
        195                 200                 205             


Ser Arg Lys Thr Ser Asp Met Val Leu Lys Arg Lys Gln Thr Lys Asp 
    210                 215                 220                 


Cys Pro Gln Arg Lys Trp Tyr Pro Leu Arg Pro Lys Lys Ile Asn Leu 
225                 230                 235                 240 


Asp Thr 
        


<210>  7033
<211>  1686
<212>  DNA
<213>  Homosapiens

<400>  7033
ccgacgaaaa atggcggggt ctcctgagtt ggtggtcctt gaccctccat gggacaagga     60

gctcgcggct ggcacagaga gccaggcctt ggtctccgcc actccccgag aagactttcg    120

ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta caactgtgcg gccgcttcgt    180

gcaaaagctc ggggacgctc tgccggagga gattcgggag cccgctctgc gagatgcgca    240

gtgggtacgg gaccagttag ccagttcttt actcatcatc ctcttaccca acacccagga    300

tcttaggatt cagaaagatc ccacgccagg ccttggcaga attaacggtg ccccaggcta    360

ctgtagaacc agttcgagaa acgctagagg agaaagaaat agatgctaat gtcagctggg    420

tcttattaat tacttagacc agcgctgtcc agtgaaaata caagactttt gaatcagctg    480

tgcaagagaa tatcagcatt aatgggcaag catggcagga agcttcagat aattgtttta    540

tggattctga catcaaagta cttgaagatc agtttgatga aatcatagta gatatagcca    600

caaaacgtaa gcagtatccc agaaagatcc tggaatgtgt catcaaaacc ataaaagcaa    660

aacaagaaat tctgcccctc atatggaaaa tttgaaatgc agaggggaaa cagtagcaaa    720

ggagatcagt gaagccatga agtccttgcc tgcattaatt gaacaaggag agggattttc    780

ccaagttctc aggatgcagc ctgttatcca cctccagagg attcaccaag aagtcttttc    840

cagttgtcat aggaaaccag atgctaaacc tgagaacttt ataacacaga tagaaaccac    900

accaacagag actgcttcca ggaaaacctc tgacatggta ctgaaaagaa agcaaactaa    960

agactgcccc cagagaaaat ggtatccatt gcggccaaag aaaattaatc ttgatacatg   1020

agctctttct gtttattttg ggagttgaaa ataggcacca tcaacattta gattacagcc   1080

taattaatac ctagataaga cttcatttga aataagaaat aactctttta ctagtgattc   1140

atttatacag atatagtatc tctgtgcggg gatatgatat aatattgtat ttccttactg   1200

ttttatctat tgtaaataaa aagcatttta aaaagtattg acacaaagcc catcagtggg   1260

cattaaaaat attaaaagtg cagactttta ctgtccttaa gtgccatcaa ctctcagctc   1320

ccttgtagct tttgtgggat ttaacaagta acaaattctg ttgtgtttcc ctggtataca   1380

tctttctagg aaaaaaaaaa aaaagagaga gagctgtata atgatttttc gtttacatgc   1440

tgaaaagtaa ttatcagttc tgcacagcag cagatgcagg gttttttttt aaagatgtag   1500

tttgatttat caaattaatg tgctgatgat aatactggct ttgactttgt tactccatgt   1560

tcagctaatt taggtttgtg agattaactt taggattttt tgttgtgtaa gacaatgata   1620

actattattt gtgcaacatt actctttgaa ataaaaattg gcatgtagcc aatgtttcct   1680

gcccac                                                              1686


<210>  7034
<211>  128
<212>  PRT
<213>  Homosapiens

<400>  7034

Met Cys His Gln Asn His Lys Ser Lys Thr Arg Asn Ser Ala Pro His 
1               5                   10                  15      


Met Glu Asn Leu Lys Cys Arg Gly Glu Thr Val Ala Lys Glu Ile Ser 
            20                  25                  30          


Glu Ala Met Lys Ser Leu Pro Ala Leu Ile Glu Gln Gly Glu Gly Phe 
        35                  40                  45              


Ser Gln Val Leu Arg Met Gln Pro Val Ile His Leu Gln Arg Ile His 
    50                  55                  60                  


Gln Glu Val Phe Ser Ser Cys His Arg Lys Pro Asp Ala Lys Pro Glu 
65                  70                  75                  80  


Asn Phe Ile Thr Gln Ile Glu Thr Thr Pro Thr Glu Thr Ala Ser Arg 
                85                  90                  95      


Lys Thr Ser Asp Met Val Leu Lys Arg Lys Gln Thr Lys Asp Cys Pro 
            100                 105                 110         


Gln Arg Lys Trp Tyr Pro Leu Arg Pro Lys Lys Ile Asn Leu Asp Thr 
        115                 120                 125             


<210>  7035
<211>  1179
<212>  DNA
<213>  Homosapiens

<400>  7035
tccgacgaaa aatggcgggg tctcctgagt tggtggtcct tgaccctcca tgggacaagg     60

agctcgcggc tggcacagag agccaggcct tggtctccgc cactccccga gaagactttc    120

gggtgcgctg cacctcgaag cgggctgtga ccgaaatgct acaactgtgc ggccgcttcg    180

tgcaaaagct cggggacgct ctgccggagg agattcggga gcccgctctg cgagatgcgc    240

agtggacttt tgaatcagct gtgcaagaga atatcagcat taatgggcaa gcatggcagg    300

aagcttcaga taattgtttt atggattctg acatcaaagt acttgaagat cagtttgatg    360

aaatcatagt agatatacac agatagaaac cacaccaaca gagactgctt ccaggaaaac    420

ctctgacatg gtactgaaaa gaaagcaaac taaagactgc ccccagagaa aatggtatcc    480

attgcggcca aagaaaatta atcttgatac atgagctctt tctgtttatt ttgggagttg    540

aaaataggca ccatcaacat ttagattaca gcctaattaa tacctagata agacttcatt    600

tgaaataaga aataactctt ttactagtga ttcatttata cagatatagt atctctgtgc    660

ggggatatga tataatattg tatttcctta ctgttttatc tattgtaaat aaaaagcatt    720

ttaaaaagta ttgacacaaa gcccatcagt gggcattaaa aatattaaaa gtgcagactt    780

ttactgtcct taagtgccat caactctcag ctcccttgta gcttttgtgg gatttaacaa    840

gtaacaaatt ctgttgtgtt tccctggtat acatctttct aggaaaaaaa aaaaaaagag    900

agagagctgt ataatgattt ttcgtttaca tgctgaaaag taattatcag ttctgcacag    960

cagcagatgc agggtttttt tttaaagatg tagtttgatt tatcaaatta atgtgctgat   1020

gataatactg gctttgactt tgttactcca tgttcagcta atttaggttt gtgagattaa   1080

ctttaggatt ttttgttgtg taagacaatg ataactatta tttgtgcaac attactcttt   1140

gaaataaaaa ttggcatgta gccaatgttt cctgcccac                          1179


<210>  7036
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  7036

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile His Arg 
        115                 120                 


<210>  7037
<211>  1404
<212>  DNA
<213>  Homosapiens

<400>  7037
acagttccga cgaaaaatgg cggggtctcc tgagttggtg gtccttgacc ctccatggga     60

caaggagctc gcggctggca cagagagcca ggccttggtc tccgccactc cccgagaaga    120

ctttcgggtg cgctgcacct cgaagcgggc tgtgaccgaa atgctacaac tgtgcggccg    180

cttcgtgcaa aagctcgggg acgctctgcc ggaggagatt cgggagcccg ctctgcgaga    240

tgcgcagtgg acttttgaat cagctgtgca agagaatatc agcattaatg ggcaagcatg    300

gcaggaagct tcagataatt gttttatgga ttctgacatc aaagtacttg aagatcagtt    360

tgatgaaatc atagtagata tagccacaaa acgtaagcag tatcccagaa agatcctgga    420

atgtgtcatc aaaaccataa aagcaaaaca agaaattctg tccttgcctg cattaattga    480

acaaggagag ggattttccc aagttctcag gatgcagcct gttatccacc tccagaggat    540

tcaccaagaa gtcttttcca gttgtcatag gaaaccagat gctaaacctg agaactttat    600

aacacagata gaaaccacac caacagagac tgcttccagg aaaacctctg acatggtact    660

gaaaagaaag caaactaaag actgccccca gagaaaatgg tatccattgc ggccaaagaa    720

aattaatctt gatacatgag ctctttctgt ttattttggg agttgaaaat aggcaccatc    780

aacatttaga ttacagccta attaatacct agataagact tcatttgaaa taagaaataa    840

ctcttttact agtgattcat ttatacagat atagtatctc tgtgcgggga tatgatataa    900

tattgtattt ccttactgtt ttatctattg taaataaaaa gcattttaaa aagtattgac    960

acaaagccca tcagtgggca ttaaaaatat taaaagtgca gacttttact gtccttaagt   1020

gccatcaact ctcagctccc ttgtagcttt tgtgggattt aacaagtaac aaattctgtt   1080

gtgtttccct ggtatacatc tttctaggaa aaaaaaaaaa aagagagaga gctgtataat   1140

gatttttcgt ttacatgctg aaaagtaatt atcagttctg cacagcagca gatgcagggt   1200

ttttttttaa agatgtagtt tgatttatca aattaatgtg ctgatgataa tactggcttt   1260

gactttgtta ctccatgttc agctaattta ggtttgtgag attaacttta ggattttttg   1320

ttgtgtaaga caatgataac tattatttgt gcaacattac tctttgaaat aaaaattggc   1380

atgtagccaa tgtttcctgc ccac                                          1404


<210>  7038
<211>  240
<212>  PRT
<213>  Homosapiens

<400>  7038

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Ser Leu Pro Ala Leu Ile Glu Gln Gly Glu Gly Phe 
145                 150                 155                 160 


Ser Gln Val Leu Arg Met Gln Pro Val Ile His Leu Gln Arg Ile His 
                165                 170                 175     


Gln Glu Val Phe Ser Ser Cys His Arg Lys Pro Asp Ala Lys Pro Glu 
            180                 185                 190         


Asn Phe Ile Thr Gln Ile Glu Thr Thr Pro Thr Glu Thr Ala Ser Arg 
        195                 200                 205             


Lys Thr Ser Asp Met Val Leu Lys Arg Lys Gln Thr Lys Asp Cys Pro 
    210                 215                 220                 


Gln Arg Lys Trp Tyr Pro Leu Arg Pro Lys Lys Ile Asn Leu Asp Thr 
225                 230                 235                 240 


<210>  7039
<211>  1476
<212>  DNA
<213>  Homosapiens

<400>  7039
gcccacagtt ccgacgaaaa atggcggggt ctcctgagtt ggtggtcctt gaccctccat     60

gggacaagga gctcgcggct ggcacagaga gccaggcctt ggtctccgcc actccccgag    120

aagactttcg ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta caactgtgcg    180

gccgcttcgt gcaaaagctc ggggacgctc tgccggagga gattcgggag cccgctctgc    240

gagatgcgca gtggactttt gaatcagctg tgcaagagaa tatcagcatt aatgggcaag    300

catggcagga agcttcagat aattgtttta tggattctga catcaaagta cttgaagatc    360

agtttgatga aatcatagta gatatagcca caaaacgtaa gcagtatccc agaaagatcc    420

tggaatgtgt catcaaaacc ataaaagcaa aacaagaaat tctgcccctc atatggaaaa    480

tttgaaatgc agaggggaaa cagtagcaaa ggagatcagt gaagccatga agtccttgcc    540

tgcattaatt gaacaaggag agggattttc ccaagttctc aggatgcagc ctgttatcca    600

cctccagagg attcaccaag aagtcttttc cagttgtcat aggaaaccag atgctaaacc    660

tgagaacttt ataacacaga tagaaaccac accaacagag actgcttcca ggaaaacctc    720

tgacatggta ctgaaaagaa agcaaactaa agactgcccc cagagaaaat ggtatccatt    780

gcggccaaag aaaattaatc ttgatacatg agctctttct gtttattttg ggagttgaaa    840

ataggcacca tcaacattta gattacagcc taattaatac ctagataaga cttcatttga    900

aataagaaat aactctttta ctagtgattc atttatacag atatagtatc tctgtgcggg    960

gatatgatat aatattgtat ttccttactg ttttatctat tgtaaataaa aagcatttta   1020

aaaagtattg acacaaagcc catcagtggg cattaaaaat attaaaagtg cagactttta   1080

ctgtccttaa gtgccatcaa ctctcagctc ccttgtagct tttgtgggat ttaacaagta   1140

acaaattctg ttgtgtttcc ctggtataca tctttctagg aaaaaaaaaa aaaagagaga   1200

gagctgtata atgatttttc gtttacatgc tgaaaagtaa ttatcagttc tgcacagcag   1260

cagatgcagg gttttttttt aaagatgtag tttgatttat caaattaatg tgctgatgat   1320

aatactggct ttgactttgt tactccatgt tcagctaatt taggtttgtg agattaactt   1380

taggattttt tgttgtgtaa gacaatgata actattattt gtgcaacatt actctttgaa   1440

ataaaaattg gcatgtagcc aatgtttcct gcccac                             1476


<210>  7040
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  7040

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Pro Leu Ile Trp Lys Ile 
145                 150                 


<210>  7041
<211>  1626
<212>  DNA
<213>  Homosapiens

<400>  7041
agagtgcccc gcccacagtt ccgacgaaaa atggcggggt ctcctgagtt ggtggtcctt     60

gaccctccat gggacaagga gctcgcggct ggcacagaga gccaggcctt ggtctccgcc    120

actccccgag aagactttcg ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta    180

caactgtgcg gccgcttcgt gcaaaagctc ggggacgctc tgccggagga gattcgggag    240

cccgctctgc gagatgcgca gtggactttt gaatcagctg tgcaagagaa tatcagcatt    300

aatgggcaag catggcagga agcttcagat aattgtttta tggattctga catcaaagta    360

cttgaagatc agtttgatga aatcatagta gatatagcca caaaacgtaa gcagtatccc    420

agaaagatcc tggaatgtgt catcaaaacc ataaaagcaa aacaagaaat tctgaagcag    480

taccaccctg ttgtacatcc actggaccta aaatatgacc ctgatccagt tctcaacggg    540

aatgctttca acttttcccc attcaacatg atgttggctg tggatttgtc atatatggtt    600

tttattactt cgagcccctc atatggaaaa tttgaaatgc agaggggaaa cagtagcaaa    660

ggagatcagt gaagccatga agtccttgcc tgcattaatt gaacaaggag agggattttc    720

ccaagttctc aggatgcagc ctgttatcca cctccagagg attcaccaag aagtcttttc    780

cagttgtcat aggaaaccag atgctaaacc tgagaacttt ataacacaga tagaaaccac    840

accaacagag actgcttcca ggaaaacctc tgacatggta ctgaaaagaa agcaaactaa    900

agactgcccc cagagaaaat ggtatccatt gcggccaaag aaaattaatc ttgatacatg    960

agctctttct gtttattttg ggagttgaaa ataggcacca tcaacattta gattacagcc   1020

taattaatac ctagataaga cttcatttga aataagaaat aactctttta ctagtgattc   1080

atttatacag atatagtatc tctgtgcggg gatatgatat aatattgtat ttccttactg   1140

ttttatctat tgtaaataaa aagcatttta aaaagtattg acacaaagcc catcagtggg   1200

cattaaaaat attaaaagtg cagactttta ctgtccttaa gtgccatcaa ctctcagctc   1260

ccttgtagct tttgtgggat ttaacaagta acaaattctg ttgtgtttcc ctggtataca   1320

tctttctagg aaaaaaaaaa aaaagagaga gagctgtata atgatttttc gtttacatgc   1380

tgaaaagtaa ttatcagttc tgcacagcag cagatgcagg gttttttttt aaagatgtag   1440

tttgatttat caaattaatg tgctgatgat aatactggct ttgactttgt tactccatgt   1500

tcagctaatt taggtttgtg agattaactt taggattttt tgttgtgtaa gacaatgata   1560

actattattt gtgcaacatt actctttgaa ataaaaattg gcatgtagcc aatgtttcct   1620

gcccac                                                              1626


<210>  7042
<211>  213
<212>  PRT
<213>  Homosapiens

<400>  7042

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Val Leu Asn Gly Asn Ala Phe Asn Phe Ser 
                165                 170                 175     


Pro Phe Asn Met Met Leu Ala Val Asp Leu Ser Tyr Met Val Phe Ile 
            180                 185                 190         


Thr Ser Ser Pro Ser Tyr Gly Lys Phe Glu Met Gln Arg Gly Asn Ser 
        195                 200                 205             


Ser Lys Gly Asp Gln 
    210             


<210>  7043
<211>  1473
<212>  DNA
<213>  Homosapiens

<400>  7043
agagtgcccc gcccacagtt ccgacgaaaa atggcggggt ctcctgagtt ggtggtcctt     60

gaccctccat gggacaagga gctcgcggct ggcacagaga gccaggcctt ggtctccgcc    120

actccccgag aagactttcg ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta    180

caactgtgcg gccgcttcgt gcaaaagctc ggggacgctc tgccggagga gattcgggag    240

cccgctctgc gagatgcgca gtggactttt gaatcagctg tgcaagagaa tatcagcatt    300

aatgggcaag catggcagga agcttcagat aattgtttta tggattctga catcaaagta    360

cttgaagatc agtttgatga aatcatagta gatatagcca caaaacgtaa gcagtatccc    420

agaaagatcc tggaatgtgt catcaaaacc ataaaagcaa aacaagaaat tctgaagcag    480

taccaccctg ttgtacatcc actggaccta aaatatgacc ctgatccagt ccttgcctgc    540

attaattgaa caaggagagg gattttccca agttctcagg atgcagcctg ttatccacct    600

ccagaggatt caccaagaag tcttttccag ttgtcatagg aaaccagatg ctaaacctga    660

gaactttata acacagatag aaaccacacc aacagagact gcttccagga aaacctctga    720

catggtactg aaaagaaagc aaactaaaga ctgcccccag agaaaatggt atccattgcg    780

gccaaagaaa attaatcttg atacatgagc tctttctgtt tattttggga gttgaaaata    840

ggcaccatca acatttagat tacagcctaa ttaataccta gataagactt catttgaaat    900

aagaaataac tcttttacta gtgattcatt tatacagata tagtatctct gtgcggggat    960

atgatataat attgtatttc cttactgttt tatctattgt aaataaaaag cattttaaaa   1020

agtattgaca caaagcccat cagtgggcat taaaaatatt aaaagtgcag acttttactg   1080

tccttaagtg ccatcaactc tcagctccct tgtagctttt gtgggattta acaagtaaca   1140

aattctgttg tgtttccctg gtatacatct ttctaggaaa aaaaaaaaaa agagagagag   1200

ctgtataatg atttttcgtt tacatgctga aaagtaatta tcagttctgc acagcagcag   1260

atgcagggtt tttttttaaa gatgtagttt gatttatcaa attaatgtgc tgatgataat   1320

actggctttg actttgttac tccatgttca gctaatttag gtttgtgaga ttaactttag   1380

gattttttgt tgtgtaagac aatgataact attatttgtg caacattact ctttgaaata   1440

aaaattggca tgtagccaat gtttcctgcc cac                                1473


<210>  7044
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  7044

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Val Leu Ala Cys Ile Asn 
                165                 170         


<210>  7045
<211>  1541
<212>  DNA
<213>  Homosapiens

<400>  7045
agagtgcccc gcccacagtt ccgacgaaaa atggcggggt ctcctgagtt ggtggtcctt     60

gaccctccat gggacaagga gctcgcggct ggcacagaga gccaggcctt ggtctccgcc    120

actccccgag aagactttcg ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta    180

caactgtgcg gccgcttcgt gcaaaagctc ggggacgctc tgccggagga gattcgggag    240

cccgctctgc gagatgcgca gtggactttt gaatcagctg tgcaagagaa tatcagcatt    300

aatgggcaag catggcagga agcttcagat aattgtttta tggattctga catcaaagta    360

cttgaagatc agtttgatga aatcatagta gatatagcca caaaacgtaa gcagtatccc    420

agaaagatcc tggaatgtgt catcaaaacc ataaaagcaa aacaagaaat tctgaagcag    480

taccaccctg ttgtacatcc actggaccta aaatatgacc ctgatccagc ccctcatatg    540

gaaaatttga aatgcagagg ggaaacagta gcaaaggaga tcagtgaagc catgaagtcc    600

ttgcctgcat taattgaaca aggagaggga ttttcccaag ttctcaggat gcagcctgtt    660

atccacctcc agaggattca ccaagaagtc ttttccagtt gtcataggaa accagatgct    720

aaacctgaga actttataac acagatagaa accacaccaa cagagactgc ttccaggaaa    780

acctctgaca tggtactgaa aagaaagcaa actaaagact gcccccagag aaaatggtat    840

ccattgcggc caaagaaaat taatcttgat acatgagctc tttctgttta ttttgggagt    900

tgaaaatagg caccatcaac atttagatta cagcctaatt aatacctaga taagacttca    960

tttgaaataa gaaataactc ttttactagt gattcattta tacagatata gtatctctgt   1020

gcggggatat gatataatat tgtatttcct tactgtttta tctattgtaa ataaaaagca   1080

ttttaaaaag tattgacaca aagcccatca gtgggcatta aaaatattaa aagtgcagac   1140

ttttactgtc cttaagtgcc atcaactctc agctcccttg tagcttttgt gggatttaac   1200

aagtaacaaa ttctgttgtg tttccctggt atacatcttt ctaggaaaaa aaaaaaaaag   1260

agagagagct gtataatgat ttttcgttta catgctgaaa agtaattatc agttctgcac   1320

agcagcagat gcagggtttt tttttaaaga tgtagtttga tttatcaaat taatgtgctg   1380

atgataatac tggctttgac tttgttactc catgttcagc taatttaggt ttgtgagatt   1440

aactttagga ttttttgttg tgtaagacaa tgataactat tatttgtgca acattactct   1500

ttgaaataaa aattggcatg tagccaatgt ttcctgccca c                       1541


<210>  7046
<211>  281
<212>  PRT
<213>  Homosapiens

<400>  7046

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Ala Pro His Met Glu Asn Leu Lys Cys Arg 
                165                 170                 175     


Gly Glu Thr Val Ala Lys Glu Ile Ser Glu Ala Met Lys Ser Leu Pro 
            180                 185                 190         


Ala Leu Ile Glu Gln Gly Glu Gly Phe Ser Gln Val Leu Arg Met Gln 
        195                 200                 205             


Pro Val Ile His Leu Gln Arg Ile His Gln Glu Val Phe Ser Ser Cys 
    210                 215                 220                 


His Arg Lys Pro Asp Ala Lys Pro Glu Asn Phe Ile Thr Gln Ile Glu 
225                 230                 235                 240 


Thr Thr Pro Thr Glu Thr Ala Ser Arg Lys Thr Ser Asp Met Val Leu 
                245                 250                 255     


Lys Arg Lys Gln Thr Lys Asp Cys Pro Gln Arg Lys Trp Tyr Pro Leu 
            260                 265                 270         


Arg Pro Lys Lys Ile Asn Leu Asp Thr 
        275                 280     


<210>  7047
<211>  769
<212>  DNA
<213>  Homosapiens

<400>  7047
agagtgcccc gcccacagtt ccgacgaaaa atggcggggt ctcctgagtt ggtggtcctt     60

gaccctccat gggacaagga gctcgcggct ggcacagaga gccaggcctt ggtctccgcc    120

actccccgag aagactttcg ggtgcgctgc acctcgaagc gggctgtgac cgaaatgcta    180

caactgtgcg gccgcttcgt gcaaaagctc ggggacgctc tgccggagga gattcgggag    240

cccgctctgc gagatgcgca gtggactttt gaatcagctg tgcaagagaa tatcagcatt    300

aatgggcaag catggcagga agcttcagat aattgtttta tggattctga catcaaagta    360

cttgaagatc agtttgatga aatcatagta gatatagcca caaaacgtaa gcagtatccc    420

agaaagatcc tggaatgtgt catcaaaacc ataaaagcaa aacaagaaat tctgaagcag    480

taccaccctg ttgtacatcc actggaccta aaatatgacc ctgatccagc ccctcatatg    540

gaaaatttga aatgcagagg ggaaacagta gcaaaggaga tcagtgaagc catgaaggta    600

aaagctatgt gctaaaaaaa ttatcaaatg aacaaaatgt atggctaggt atttgcattc    660

aacattcata tgtgttttag tctgctctaa caggaattct cagcggtcct ttaaataaat    720

ctttaatgaa tttattaagc aacagtaaca tttagaatag ctgccattt                769


<210>  7048
<211>  194
<212>  PRT
<213>  Homosapiens

<400>  7048

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Ala Pro His Met Glu Asn Leu Lys Cys Arg 
                165                 170                 175     


Gly Glu Thr Val Ala Lys Glu Ile Ser Glu Ala Met Lys Val Lys Ala 
            180                 185                 190         


Met Cys 
        


<210>  7049
<211>  943
<212>  DNA
<213>  Homosapiens

<400>  7049
acagttccga cgaaaaatgg cggggtctcc tgagttggtg gtccttgacc ctccatggga     60

caaggagctc gcggctggca cagagagcca ggccttggtc tccgccactc cccgagaaga    120

ctttcgggtg cgctgcacct cgaagcgggc tgtgaccgaa atgctacaac tgtgcggccg    180

cttcgtgcaa aagctcgggg acgctctgcc ggaggagatt cgggagcccg ctctgcgaga    240

tgcgcagtgg acttttgaat cagctgtgca agagaatatc agcattaatg ggcaagcatg    300

gcaggaagct tcagataatt gttttatgga ttctgacatc aaagtacttg aagatcagtt    360

tgatgaaatc atagtagata tagccacaaa acgtaagcag tatcccagaa agatcctgga    420

atgtgtcatc aaaaccataa aagcaaaaca agaaattctg aagcagtacc accctgttgt    480

acatccactg gacctaaaat atgaccctga tccaggtgag tcagtatcca tttgtggtaa    540

aaatgaagca tctgcttata atttttatgg gtttctgata ttcttctaaa agggtcagca    600

tcaaggatat tctccctttg atgctttaac ttcctaccag tcattcatgt ttagcatttc    660

atctagaatt aagaggacta gctttacacc cattgactca gaattccagg ggtgttaccc    720

cggaatctga gcttttataa agttcttgcc tgacccagac tattataaca catacccatc    780

tctaacttct aataccctcc tatctctgtc attgtactat ctattctttg cattacagcc    840

aaagctatac tattaaagca ttctctcata gtgtcacacc tggtgcagta accatcattg    900

gtttctcatt atttctaaaa tcaaataaaa atatattgaa ttt                      943


<210>  7050
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  7050

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu 
145                 150                 155                 160 


Lys Tyr Asp Pro Asp Pro Gly Glu Ser Val Ser Ile Cys Gly Lys Asn 
                165                 170                 175     


Glu Ala Ser Ala Tyr Asn Phe Tyr Gly Phe Leu Ile Phe Phe 
            180                 185                 190 


<210>  7051
<211>  1351
<212>  DNA
<213>  Homosapiens

<400>  7051
agttccgacg aaaaatggcg gggtctcctg agttggtggt ccttgaccct ccatgggaca     60

aggagctcgc ggctggcaca gagagccagg ccttggtctc cgccactccc cgagaagact    120

ttcgggtgcg ctgcacctcg aagcgggctg tgaccgaaat gctacaactg tgcggccgct    180

tcgtgcaaaa gctcggggac gctctgccgg aggagattcg ggagcccgct ctgcgagatg    240

cgcagtggac ttttgaatca gctgtgcaag agaatatcag cattaatggg caagcatggc    300

aggaagcttc agataattgt tttatggatt ctgacatcaa agtacttgaa gatcagtttg    360

atgaaatcat agtagatata gccacaaaac gtaagcagta tcccagaaag atcctggaat    420

gtgtcatcaa aaccataaaa gcaaaacaag aaattctggt aagatgattt gcctttaaaa    480

tgttatagta tattttacca caataaaaac attaaaatat aaggctctac gtggagataa    540

gtgacatttt gttgtctttt tctttcctgc ctcaattagt attgtttgtc tcttgtaaga    600

ctttactctt ctaagttgta ctatgacata gtatagtcat actatactgt gttttgaaca    660

cactggttca aaaatgaaaa aaatgaaagt tatagtgagt ggttaaaatt gaaattggtg    720

atggaagact gacaatgact ttatgattct gagacaagga tggaaaaaga agcttttctt    780

ttaacacttt tctttctgtt tgttgttttt ttttggcata tatttgtatg tttgtatatt    840

ttggaagacc atttagttaa attgatgatg aagattgttt tagtacctgt tcataacact    900

gaaatttgct ttatgaattg ggtgtaattt gttttgctgc aaaaatcatg aacatctggg    960

tgacaagacc aggaattcag ctccttcagc acgagctttt tagacaagca gagccgtaga   1020

cttccttctt ataattacta tagatatcaa tgaccaacca tatcacaccc tcatcttttc   1080

agatttatta ggactagaat aaataaaaaa taggaaatcc acaagaaaat tggacccaaa   1140

tcttcccttg gtggggaggg gaggtttgct gggaatagca ttgtccctcc agtgaggtac   1200

atgttgtgtt tagattgtgc tatactattg cctttagttt ttgaaattag tacataaatg   1260

ttcacatata aatcttctag ttgcctcagt ttcaggattg tttcaggtca ttatatgccc   1320

ggcttaatat tgtatctaaa acattttagt t                                  1351


<210>  7052
<211>  150
<212>  PRT
<213>  Homosapiens

<400>  7052

Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp Asp Lys 
1               5                   10                  15      


Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala Thr Pro 
            20                  25                  30          


Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val Thr Glu 
        35                  40                  45              


Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu 
    50                  55                  60                  


Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe 
65                  70                  75                  80  


Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln 
                85                  90                  95      


Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu 
            100                 105                 110         


Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln 
        115                 120                 125             


Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys 
    130                 135                 140                 


Gln Glu Ile Leu Val Arg 
145                 150 


<210>  7053
<211>  579
<212>  DNA
<213>  Homosapiens

<400>  7053
ggaaactcag gacgctgcag ctgaaacgtt ccggctccgg ctctgctggc cggtctaaag     60

cggcagccgc cggggcgcaa tgcgagcggc tggcgtaggc ttggtggact gtcactgcca    120

cctctccgcc ccggactttg accgcgattt ggatgatgtg ttggagaaag ccaagaaggc    180

caatgttgtg gcccttgtgg cagttgccga acattcagga gaatttgaaa agattatgca    240

actttcagaa aggtataatg ggtttgtcct gccatgcttg ggtgttcatc cagttcaagg    300

acttccacca gaagaccaaa gaagtgtcac actaaaggat ttggatgtag ctttgcccat    360

tattgagaat tataaggatc ggttgttggc aattggagag gttggactag atttctcccc    420

cagatttgct ggcactggtg aacagaagga agagcaaaga caagtcctaa tcagacagat    480

ccagttagcc aaaagactaa atttgcctgt gtaggttaat tattttccta tgttaatagc    540

tatagagcaa attaaataat gatcagagtt ctcctgaaa                           579


<210>  7054
<211>  144
<212>  PRT
<213>  Homosapiens

<400>  7054

Met Arg Ala Ala Gly Val Gly Leu Val Asp Cys His Cys His Leu Ser 
1               5                   10                  15      


Ala Pro Asp Phe Asp Arg Asp Leu Asp Asp Val Leu Glu Lys Ala Lys 
            20                  25                  30          


Lys Ala Asn Val Val Ala Leu Val Ala Val Ala Glu His Ser Gly Glu 
        35                  40                  45              


Phe Glu Lys Ile Met Gln Leu Ser Glu Arg Tyr Asn Gly Phe Val Leu 
    50                  55                  60                  


Pro Cys Leu Gly Val His Pro Val Gln Gly Leu Pro Pro Glu Asp Gln 
65                  70                  75                  80  


Arg Ser Val Thr Leu Lys Asp Leu Asp Val Ala Leu Pro Ile Ile Glu 
                85                  90                  95      


Asn Tyr Lys Asp Arg Leu Leu Ala Ile Gly Glu Val Gly Leu Asp Phe 
            100                 105                 110         


Ser Pro Arg Phe Ala Gly Thr Gly Glu Gln Lys Glu Glu Gln Arg Gln 
        115                 120                 125             


Val Leu Ile Arg Gln Ile Gln Leu Ala Lys Arg Leu Asn Leu Pro Val 
    130                 135                 140                 


<210>  7055
<211>  2370
<212>  DNA
<213>  Homosapiens

<400>  7055
ggaaactcag gacgctgcag ctgaaacgtt ccggctccgg ctctgctggc cggtctaaag     60

cggcagccgc cggggcgcaa tgcgagcggc tggcgtaggc ttggtggact gtcactgcca    120

cctctccgcc ccggactttg accgcgattt ggatgatgtg ttggagaaag ccaagaaggc    180

caatgttgtg gcccttgtgg cagttgccga acattcagga gaatttgaaa agattatgca    240

actttcagaa aggtataatg ggtttgtcct gccatgcttg ggtgttcatc cagttcaagg    300

acttccacca gaagaccaaa gaagtgtcac actaaaggat ttggatgtag ctttgcccat    360

tattgagaat tataaggatc ggttgttggc aattggagag gttggactag atttctcccc    420

cagatttgct ggcactggtg aacagaagga agagcaaaga caagtcctaa tcagacagat    480

ccagttagcc aaaagactaa atttgcctgt aaatgtgcac tcacgctctg ctggaagacc    540

taccatcaac cttttacaag agcaaggtgc tgagaaggta ctgctgcatg catttgatgg    600

tcggccatct gtagccatgg aaggagtaag agctgggtac ttcttctcaa ttcccccttc    660

tatcataaga agtggacagc agaaacttgt gaaacaattg cctttaactt ctatatgctt    720

agaaacagat tcacctgcac taggaccaga aaaacaggta cggaatgagc cctggaacat    780

ttctatttca gcagaatata ttgcccaggt gaaagggatc tcagtggaag aagttataga    840

agtgacgaca cagaatgcat taaaactgtt tcctaagctc cgacacttgc tccagaaata    900

gcttcaaaac catccattac aaaatcgaat caactgcagg gggcagcatt tgaaaaatag    960

aaatgttctg atgaagaatc tgaactgaag aagctgtttt atagggttat agaagattgt   1020

aattgtagag aaatatttct cttagaaata aaactgggct tggatcctga aaccctgggt   1080

tctgattcta gccttgtgct gcttttcaat tagccgagtt ctggcaggat attgggaaaa   1140

tactgctact tcttacattg cccttttata tagaaccacc acctgaactg aaaccattgc   1200

tactgggaag ggtggctccc acaggaagag tataagcact actgtgatga ggatggagta   1260

agctaaagta tacttttttt tttttttgat ggagtttcgc tgttgttgcc caggctggag   1320

tgcaatggca cgatcttggc tcactgcaac ctccacttcc caggttctag cgagtctcct   1380

ccctcagcct cccaagtagc tgggattaca ggcatgtgcc accatgccca gctaattttg   1440

tatttttagt agagacaggg tttctccatg ttggtcaggc tggtctcgaa ctcccgacct   1500

caggtgatcc gcccgcctcg gcctcccaaa gtgctgggat tacaggcatg agccactgcg   1560

ccagcctaaa gtgtgttctt accacctatt tttcttccca taggagttag ccagtgaagg   1620

gagaatgtct ggttttctat gctgtcagaa atctcttttc taggtttgta aaattgaact   1680

tttagtactt cgaattattt ctctttaaga taaaaatgca tacgattttt acactgatct   1740

tagatttttg acttatgagg ccagtggttt aaacaatcat tattgaatac caagcccaaa   1800

agtttagtta atacaccaat tgtaagttct ggtctgaatt ttgtcaacat atttagaatg   1860

taaatggcat tattaaaaat gtatctgatt tctctgtgaa cagtaatatt tcatattttt   1920

aagtttaaaa atgttagtgt aagccaggca cagtggcatt cacctgtagt gccaaccact   1980

caggaggctg agatgggaga ccttttaagc ctgagtttga gtcaggcctg ggcaacatag   2040

atgtgagcac ctatctctaa aaatgtaaat aaataaaaat ctcaaaaaaa ttaaaaatct   2100

caagtgtaaa aacagttctg tagatagatg gtagtgatgg tagcacatca atgtgaaggt   2160

atttaatgcc actgaactgt acacttataa cgaattagga taaattttat gttatgtgta   2220

tttactacaa ttttttaaaa atcgtatatg tagtttaaca ggtgtggtca atatcaaaac   2280

ttaggtattt aatcttgtta aattatataa gcagaaaatg ctggaaaaag tacctgtcat   2340

agaaaaaaat aaacttccta aatcaaagtg                                    2370


<210>  7056
<211>  273
<212>  PRT
<213>  Homosapiens

<400>  7056

Met Arg Ala Ala Gly Val Gly Leu Val Asp Cys His Cys His Leu Ser 
1               5                   10                  15      


Ala Pro Asp Phe Asp Arg Asp Leu Asp Asp Val Leu Glu Lys Ala Lys 
            20                  25                  30          


Lys Ala Asn Val Val Ala Leu Val Ala Val Ala Glu His Ser Gly Glu 
        35                  40                  45              


Phe Glu Lys Ile Met Gln Leu Ser Glu Arg Tyr Asn Gly Phe Val Leu 
    50                  55                  60                  


Pro Cys Leu Gly Val His Pro Val Gln Gly Leu Pro Pro Glu Asp Gln 
65                  70                  75                  80  


Arg Ser Val Thr Leu Lys Asp Leu Asp Val Ala Leu Pro Ile Ile Glu 
                85                  90                  95      


Asn Tyr Lys Asp Arg Leu Leu Ala Ile Gly Glu Val Gly Leu Asp Phe 
            100                 105                 110         


Ser Pro Arg Phe Ala Gly Thr Gly Glu Gln Lys Glu Glu Gln Arg Gln 
        115                 120                 125             


Val Leu Ile Arg Gln Ile Gln Leu Ala Lys Arg Leu Asn Leu Pro Val 
    130                 135                 140                 


Asn Val His Ser Arg Ser Ala Gly Arg Pro Thr Ile Asn Leu Leu Gln 
145                 150                 155                 160 


Glu Gln Gly Ala Glu Lys Val Leu Leu His Ala Phe Asp Gly Arg Pro 
                165                 170                 175     


Ser Val Ala Met Glu Gly Val Arg Ala Gly Tyr Phe Phe Ser Ile Pro 
            180                 185                 190         


Pro Ser Ile Ile Arg Ser Gly Gln Gln Lys Leu Val Lys Gln Leu Pro 
        195                 200                 205             


Leu Thr Ser Ile Cys Leu Glu Thr Asp Ser Pro Ala Leu Gly Pro Glu 
    210                 215                 220                 


Lys Gln Val Arg Asn Glu Pro Trp Asn Ile Ser Ile Ser Ala Glu Tyr 
225                 230                 235                 240 


Ile Ala Gln Val Lys Gly Ile Ser Val Glu Glu Val Ile Glu Val Thr 
                245                 250                 255     


Thr Gln Asn Ala Leu Lys Leu Phe Pro Lys Leu Arg His Leu Leu Gln 
            260                 265                 270         


Lys 
    


<210>  7057
<211>  2257
<212>  DNA
<213>  Homosapiens

<400>  7057
ggaaactcag gacgctgcag ctgaaacgtt ccggctccgg ctctgctggc cggtctaaag     60

cggcagccgc cggggcgcaa tgcgagcggc tggcgtaggc ttggtggact gtcactgcca    120

cctctccgcc ccggactttg accgcgattt ggatgatgtg ttggagaaag ccaagaaggc    180

caatgttgtg gcccttgtgg cagttgccga acattcagga gaatttgaaa agattatgca    240

actttcagaa aggtataatg ggtttgtcct gccatgcttg ggtgttcatc cagttcaagg    300

acttccacca gaagaccaaa gaagtgtcac actaaaggat ttggatgtag ctttgcccat    360

tattgagaat tataaggatc ggttgttggc aattggagag gttggactag atttctcccc    420

cagatttgct ggcactggtg aacagaagga agagcaaaga caagtcctaa tcagacagat    480

ccagttagcc aaaagactaa atttgcctgt aaatgtgcac tcacgctctg ctggaagacc    540

taccatcaac cttttacaag agcaagcaga aacttgtgaa acaattgcct ttaacttcta    600

tatgcttaga aacagattca cctgcactag gaccagaaaa acaggtacgg aatgagccct    660

ggaacatttc tatttcagca gaatatattg cccaggtgaa agggatctca gtggaagaag    720

ttatagaagt gacgacacag aatgcattaa aactgtttcc taagctccga cacttgctcc    780

agaaatagct tcaaaaccat ccattacaaa atcgaatcaa ctgcaggggg cagcatttga    840

aaaatagaaa tgttctgatg aagaatctga actgaagaag ctgttttata gggttataga    900

agattgtaat tgtagagaaa tatttctctt agaaataaaa ctgggcttgg atcctgaaac    960

cctgggttct gattctagcc ttgtgctgct tttcaattag ccgagttctg gcaggatatt   1020

gggaaaatac tgctacttct tacattgccc ttttatatag aaccaccacc tgaactgaaa   1080

ccattgctac tgggaagggt ggctcccaca ggaagagtat aagcactact gtgatgagga   1140

tggagtaagc taaagtatac tttttttttt ttttgatgga gtttcgctgt tgttgcccag   1200

gctggagtgc aatggcacga tcttggctca ctgcaacctc cacttcccag gttctagcga   1260

gtctcctccc tcagcctccc aagtagctgg gattacaggc atgtgccacc atgcccagct   1320

aattttgtat ttttagtaga gacagggttt ctccatgttg gtcaggctgg tctcgaactc   1380

ccgacctcag gtgatccgcc cgcctcggcc tcccaaagtg ctgggattac aggcatgagc   1440

cactgcgcca gcctaaagtg tgttcttacc acctattttt cttcccatag gagttagcca   1500

gtgaagggag aatgtctggt tttctatgct gtcagaaatc tcttttctag gtttgtaaaa   1560

ttgaactttt agtacttcga attatttctc tttaagataa aaatgcatac gatttttaca   1620

ctgatcttag atttttgact tatgaggcca gtggtttaaa caatcattat tgaataccaa   1680

gcccaaaagt ttagttaata caccaattgt aagttctggt ctgaattttg tcaacatatt   1740

tagaatgtaa atggcattat taaaaatgta tctgatttct ctgtgaacag taatatttca   1800

tatttttaag tttaaaaatg ttagtgtaag ccaggcacag tggcattcac ctgtagtgcc   1860

aaccactcag gaggctgaga tgggagacct tttaagcctg agtttgagtc aggcctgggc   1920

aacatagatg tgagcaccta tctctaaaaa tgtaaataaa taaaaatctc aaaaaaatta   1980

aaaatctcaa gtgtaaaaac agttctgtag atagatggta gtgatggtag cacatcaatg   2040

tgaaggtatt taatgccact gaactgtaca cttataacga attaggataa attttatgtt   2100

atgtgtattt actacaattt tttaaaaatc gtatatgtag tttaacaggt gtggtcaata   2160

tcaaaactta ggtatttaat cttgttaaat tatataagca gaaaatgctg gaaaaagtac   2220

ctgtcataga aaaaaataaa cttcctaaat caaagtg                            2257


<210>  7058
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  7058

Met Arg Ala Ala Gly Val Gly Leu Val Asp Cys His Cys His Leu Ser 
1               5                   10                  15      


Ala Pro Asp Phe Asp Arg Asp Leu Asp Asp Val Leu Glu Lys Ala Lys 
            20                  25                  30          


Lys Ala Asn Val Val Ala Leu Val Ala Val Ala Glu His Ser Gly Glu 
        35                  40                  45              


Phe Glu Lys Ile Met Gln Leu Ser Glu Arg Tyr Asn Gly Phe Val Leu 
    50                  55                  60                  


Pro Cys Leu Gly Val His Pro Val Gln Gly Leu Pro Pro Glu Asp Gln 
65                  70                  75                  80  


Arg Ser Val Thr Leu Lys Asp Leu Asp Val Ala Leu Pro Ile Ile Glu 
                85                  90                  95      


Asn Tyr Lys Asp Arg Leu Leu Ala Ile Gly Glu Val Gly Leu Asp Phe 
            100                 105                 110         


Ser Pro Arg Phe Ala Gly Thr Gly Glu Gln Lys Glu Glu Gln Arg Gln 
        115                 120                 125             


Val Leu Ile Arg Gln Ile Gln Leu Ala Lys Arg Leu Asn Leu Pro Val 
    130                 135                 140                 


Asn Val His Ser Arg Ser Ala Gly Arg Pro Thr Ile Asn Leu Leu Gln 
145                 150                 155                 160 


Glu Gln Ala Glu Thr Cys Glu Thr Ile Ala Phe Asn Phe Tyr Met Leu 
                165                 170                 175     


Arg Asn Arg Phe Thr Cys Thr Arg Thr Arg Lys Thr Gly Thr Glu 
            180                 185                 190     


<210>  7059
<211>  2923
<212>  DNA
<213>  Homosapiens

<400>  7059
ggaaactcag gacgctgcag ctgaaacgtt ccggctccgg ctctgctggc cggtctaaag     60

cggcagccgc cggggcgcaa tgcgagcggc tggcgtaggc ttggtggact gtcactgcca    120

cctctccgcc ccggactttg accgcgattt ggatgatgtg ttggagaaag ccaagaaggc    180

caatgttgtg gcccttgtgg cagttgccga acattcagga gaatttgaaa agattatgca    240

actttcagaa aggtataatg ggtttgtcct gccatgcttg ggtgttcatc cagttcaagg    300

acttccacca gaagaccaaa gaagtgtcac actaaaggat ttggatgtag ctttgcccat    360

tattgagaat tataaggatc ggttgttggc aattggagag gttggactag atttctcccc    420

cagatttgct ggcactggtg aacagaagga agagcaaaga caagtcctaa tcagacagat    480

ccagttagcc aaaagactaa atttgcctgt aaatgtgcac tcacgctctg ctggaagacc    540

taccatcaac cttttacaag agcaaggtgc tgagaaggta ctgctgcatg catttgatgg    600

tcggccatct gtagccatgg aaggagtaag agctgggtac ttcttctcaa ttcccccttc    660

tatcataaga agtggacagc agaaacttgt gaaacaattg cctttaactt ctatatgctt    720

agaaacagat tcacctgcac taggaccaga aaaacaggta cggaatgagc cctggaacat    780

ttctatttca gcagaatata ttgcccaggt gaaagggatc tcagtggaag aagttataga    840

agtgacgaca cagaatgcat taaaactgtt tcctaagctc cgacacttgc tccagaaata    900

gcttcaaaac catccattac aaaatcgaat caactgcagg gggcagcatt tgaaaaatag    960

aaatgttctg atgaagaatc tgaactgaag aagctgtttt atagggttat agaagattgt   1020

aattgtagag aaatatttct cttagaaata aaactgggct tggatcctga aaccctgggt   1080

tctgattcta gccttgtgct gcttttcaat tagccgagtt ctggcaggat attgggaaaa   1140

tactgctact tcttacattg cccttttata tagaaccacc acctgaactg aaaccattgc   1200

tactgggaag ggtggctccc acaggaagag tataagcact actgtgatga ggatggagta   1260

agctaaagta tacttttttt tttttttgat ggagtttcgc tgttgttgcc caggctggag   1320

tgcaatggca cgatcttggc tcactgcaac ctccacttcc caggttctag cgagtctcct   1380

ccctcagcct cccaagtagc tgggattaca ggcatgtgcc accatgccca gctaattttg   1440

tatttttagt agagacaggg tttctccatg ttggtcaggc tggtctcgaa ctcccgacct   1500

caggtgatcc gcccgcctcg gcctcccaaa gtgctgggat tacaggcatg agccactgcg   1560

ccagcctaaa gtgtgttctt accacctatt tttcttccca taggagttag ccagtgaagg   1620

gagaatgtct ggttttctat gctgtcagaa atctcttttc taggtttgta aaattgaact   1680

tttagtactt cgaattattt ctctttaaga taaaaatgca tacgattttt acactgatct   1740

tagatttttg acttatgagg ccagtggttt aaacaatcat tattgaatac caagcccaaa   1800

agtttagtta atacaccaat tgtaagttct ggtctgaatt ttgtcaacat atttagaatg   1860

taaatggcat tattaaaaat gtatctgatt tctctgtgaa cagtaatatt tcatattttt   1920

aagtttaaaa atgttagtgt aagccaggca cagtggcatt cacctgtagt gccaaccact   1980

caggaggctg agatgggaga ccttttaagc ctgagtttga gtcaggcctg ggcaacatag   2040

atgtgagcac ctatctctaa aaatgtaaat aaataaaaat ctcaaaaaaa ttaaaaatct   2100

caagtgtaaa aacagttctg tagatagatg gtagtgatgg tagcacatca atgtgaaggt   2160

atttaatgcc actgaactgt acacttataa cgaattagga taaattttat gttatgtgta   2220

tttactacaa ttttttaaaa atcgtatatg tagtttaaca ggtgtggtca atatcaaaac   2280

ttaggtattt aatcttgtta aattatataa gcagaaaatg ctggaaaaag tacctgtcat   2340

agaaaaaaat aaacttccta aatcaaagtg attttatgaa atgatcttca ataaatattt   2400

tgaaatgaat tcatttatgg aagaatcaaa actaggtcag attgtccaaa ccagactaag   2460

aaactgaata gggtatttta tgaggtattt aatgactcat cagcaccatt ttaaatgaaa   2520

ttcctacatt taacaggaga ttatattaaa actggacttt taagctctct tccaactctg   2580

tatttctttt ccctatttcc taccttctgt acacataccc tttgtcagac tcttaccatt   2640

aaatcgttta aggttcaagt taaattactt catcttgcct catcacccag ccagacatga   2700

tctttgccct ctaaattgtt tagccatttt cttcatgtat tcatccattt gtttgtttca   2760

gttattaagc ccctcctcct ataggctgcc cactagtcta ggttcctagg ttacaaagat   2820

gaataagata tgatctttgc cctcagttca caatttaatc aaggagatag ccaagtggac   2880

aaataatttc atagcaatgt gagaagtgct attgttagag gaa                     2923


<210>  7060
<211>  273
<212>  PRT
<213>  Homosapiens

<400>  7060

Met Arg Ala Ala Gly Val Gly Leu Val Asp Cys His Cys His Leu Ser 
1               5                   10                  15      


Ala Pro Asp Phe Asp Arg Asp Leu Asp Asp Val Leu Glu Lys Ala Lys 
            20                  25                  30          


Lys Ala Asn Val Val Ala Leu Val Ala Val Ala Glu His Ser Gly Glu 
        35                  40                  45              


Phe Glu Lys Ile Met Gln Leu Ser Glu Arg Tyr Asn Gly Phe Val Leu 
    50                  55                  60                  


Pro Cys Leu Gly Val His Pro Val Gln Gly Leu Pro Pro Glu Asp Gln 
65                  70                  75                  80  


Arg Ser Val Thr Leu Lys Asp Leu Asp Val Ala Leu Pro Ile Ile Glu 
                85                  90                  95      


Asn Tyr Lys Asp Arg Leu Leu Ala Ile Gly Glu Val Gly Leu Asp Phe 
            100                 105                 110         


Ser Pro Arg Phe Ala Gly Thr Gly Glu Gln Lys Glu Glu Gln Arg Gln 
        115                 120                 125             


Val Leu Ile Arg Gln Ile Gln Leu Ala Lys Arg Leu Asn Leu Pro Val 
    130                 135                 140                 


Asn Val His Ser Arg Ser Ala Gly Arg Pro Thr Ile Asn Leu Leu Gln 
145                 150                 155                 160 


Glu Gln Gly Ala Glu Lys Val Leu Leu His Ala Phe Asp Gly Arg Pro 
                165                 170                 175     


Ser Val Ala Met Glu Gly Val Arg Ala Gly Tyr Phe Phe Ser Ile Pro 
            180                 185                 190         


Pro Ser Ile Ile Arg Ser Gly Gln Gln Lys Leu Val Lys Gln Leu Pro 
        195                 200                 205             


Leu Thr Ser Ile Cys Leu Glu Thr Asp Ser Pro Ala Leu Gly Pro Glu 
    210                 215                 220                 


Lys Gln Val Arg Asn Glu Pro Trp Asn Ile Ser Ile Ser Ala Glu Tyr 
225                 230                 235                 240 


Ile Ala Gln Val Lys Gly Ile Ser Val Glu Glu Val Ile Glu Val Thr 
                245                 250                 255     


Thr Gln Asn Ala Leu Lys Leu Phe Pro Lys Leu Arg His Leu Leu Gln 
            260                 265                 270         


Lys 
    


<210>  7061
<211>  2810
<212>  DNA
<213>  Homosapiens

<400>  7061
ggaaactcag gacgctgcag ctgaaacgtt ccggctccgg ctctgctggc cggtctaaag     60

cggcagccgc cggggcgcaa tgcgagcggc tggcgtaggc ttggtggact gtcactgcca    120

cctctccgcc ccggactttg accgcgattt ggatgatgtg ttggagaaag ccaagaaggc    180

caatgttgtg gcccttgtgg cagttgccga acattcagga gaatttgaaa agattatgca    240

actttcagaa aggtataatg ggtttgtcct gccatgcttg ggtgttcatc cagttcaagg    300

acttccacca gaagaccaaa gaagtgtcac actaaaggat ttggatgtag ctttgcccat    360

tattgagaat tataaggatc ggttgttggc aattggagag gttggactag atttctcccc    420

cagatttgct ggcactggtg aacagaagga agagcaaaga caagtcctaa tcagacagat    480

ccagttagcc aaaagactaa atttgcctgt aaatgtgcac tcacgctctg ctggaagacc    540

taccatcaac cttttacaag agcaagcaga aacttgtgaa acaattgcct ttaacttcta    600

tatgcttaga aacagattca cctgcactag gaccagaaaa acaggtacgg aatgagccct    660

ggaacatttc tatttcagca gaatatattg cccaggtgaa agggatctca gtggaagaag    720

ttatagaagt gacgacacag aatgcattaa aactgtttcc taagctccga cacttgctcc    780

agaaatagct tcaaaaccat ccattacaaa atcgaatcaa ctgcaggggg cagcatttga    840

aaaatagaaa tgttctgatg aagaatctga actgaagaag ctgttttata gggttataga    900

agattgtaat tgtagagaaa tatttctctt agaaataaaa ctgggcttgg atcctgaaac    960

cctgggttct gattctagcc ttgtgctgct tttcaattag ccgagttctg gcaggatatt   1020

gggaaaatac tgctacttct tacattgccc ttttatatag aaccaccacc tgaactgaaa   1080

ccattgctac tgggaagggt ggctcccaca ggaagagtat aagcactact gtgatgagga   1140

tggagtaagc taaagtatac tttttttttt ttttgatgga gtttcgctgt tgttgcccag   1200

gctggagtgc aatggcacga tcttggctca ctgcaacctc cacttcccag gttctagcga   1260

gtctcctccc tcagcctccc aagtagctgg gattacaggc atgtgccacc atgcccagct   1320

aattttgtat ttttagtaga gacagggttt ctccatgttg gtcaggctgg tctcgaactc   1380

ccgacctcag gtgatccgcc cgcctcggcc tcccaaagtg ctgggattac aggcatgagc   1440

cactgcgcca gcctaaagtg tgttcttacc acctattttt cttcccatag gagttagcca   1500

gtgaagggag aatgtctggt tttctatgct gtcagaaatc tcttttctag gtttgtaaaa   1560

ttgaactttt agtacttcga attatttctc tttaagataa aaatgcatac gatttttaca   1620

ctgatcttag atttttgact tatgaggcca gtggtttaaa caatcattat tgaataccaa   1680

gcccaaaagt ttagttaata caccaattgt aagttctggt ctgaattttg tcaacatatt   1740

tagaatgtaa atggcattat taaaaatgta tctgatttct ctgtgaacag taatatttca   1800

tatttttaag tttaaaaatg ttagtgtaag ccaggcacag tggcattcac ctgtagtgcc   1860

aaccactcag gaggctgaga tgggagacct tttaagcctg agtttgagtc aggcctgggc   1920

aacatagatg tgagcaccta tctctaaaaa tgtaaataaa taaaaatctc aaaaaaatta   1980

aaaatctcaa gtgtaaaaac agttctgtag atagatggta gtgatggtag cacatcaatg   2040

tgaaggtatt taatgccact gaactgtaca cttataacga attaggataa attttatgtt   2100

atgtgtattt actacaattt tttaaaaatc gtatatgtag tttaacaggt gtggtcaata   2160

tcaaaactta ggtatttaat cttgttaaat tatataagca gaaaatgctg gaaaaagtac   2220

ctgtcataga aaaaaataaa cttcctaaat caaagtgatt ttatgaaatg atcttcaata   2280

aatattttga aatgaattca tttatggaag aatcaaaact aggtcagatt gtccaaacca   2340

gactaagaaa ctgaataggg tattttatga ggtatttaat gactcatcag caccatttta   2400

aatgaaattc ctacatttaa caggagatta tattaaaact ggacttttaa gctctcttcc   2460

aactctgtat ttcttttccc tatttcctac cttctgtaca catacccttt gtcagactct   2520

taccattaaa tcgtttaagg ttcaagttaa attacttcat cttgcctcat cacccagcca   2580

gacatgatct ttgccctcta aattgtttag ccattttctt catgtattca tccatttgtt   2640

tgtttcagtt attaagcccc tcctcctata ggctgcccac tagtctaggt tcctaggtta   2700

caaagatgaa taagatatga tctttgccct cagttcacaa tttaatcaag gagatagcca   2760

agtggacaaa taatttcata gcaatgtgag aagtgctatt gttagaggaa              2810


<210>  7062
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  7062

Met Arg Ala Ala Gly Val Gly Leu Val Asp Cys His Cys His Leu Ser 
1               5                   10                  15      


Ala Pro Asp Phe Asp Arg Asp Leu Asp Asp Val Leu Glu Lys Ala Lys 
            20                  25                  30          


Lys Ala Asn Val Val Ala Leu Val Ala Val Ala Glu His Ser Gly Glu 
        35                  40                  45              


Phe Glu Lys Ile Met Gln Leu Ser Glu Arg Tyr Asn Gly Phe Val Leu 
    50                  55                  60                  


Pro Cys Leu Gly Val His Pro Val Gln Gly Leu Pro Pro Glu Asp Gln 
65                  70                  75                  80  


Arg Ser Val Thr Leu Lys Asp Leu Asp Val Ala Leu Pro Ile Ile Glu 
                85                  90                  95      


Asn Tyr Lys Asp Arg Leu Leu Ala Ile Gly Glu Val Gly Leu Asp Phe 
            100                 105                 110         


Ser Pro Arg Phe Ala Gly Thr Gly Glu Gln Lys Glu Glu Gln Arg Gln 
        115                 120                 125             


Val Leu Ile Arg Gln Ile Gln Leu Ala Lys Arg Leu Asn Leu Pro Val 
    130                 135                 140                 


Asn Val His Ser Arg Ser Ala Gly Arg Pro Thr Ile Asn Leu Leu Gln 
145                 150                 155                 160 


Glu Gln Ala Glu Thr Cys Glu Thr Ile Ala Phe Asn Phe Tyr Met Leu 
                165                 170                 175     


Arg Asn Arg Phe Thr Cys Thr Arg Thr Arg Lys Thr Gly Thr Glu 
            180                 185                 190     


<210>  7063
<211>  502
<212>  DNA
<213>  Homosapiens

<400>  7063
tcccagtggg ctaatccaca ccagtggact tgaaacacgc tttgggttgc tgtatggtag     60

tatgctaaag gacagcaaga atcacttgac aattggtttg tgaccataat ggcatctata    120

aacagaacca ttgaaataat gaaaaaacat ggagtaagca aacaacatct cctggaggag    180

ataaacaaaa agcgtgaatc caactgcttg gtggaacgaa gcaatcaagt cagcttactg    240

agagttcaaa agaggcactt cccggatgcc tatcagtcct ttactgatac cacaaccaaa    300

gagcctgttc ccaacagtgg caggagctcc tggatcaagc tgagtctcct tgctcacatg    360

gagagaaagc actttccacc aaaaaataat gccatatttg gataaagtgc atctccagag    420

acacacggaa atacattctc tttgattctt cttcagtgtg tctaaattat ttacaaatta    480

ttaattataa acaaagctaa ac                                             502


<210>  7064
<211>  98
<212>  PRT
<213>  Homosapiens

<400>  7064

Met Ala Ser Ile Asn Arg Thr Ile Glu Ile Met Lys Lys His Gly Val 
1               5                   10                  15      


Ser Lys Gln His Leu Leu Glu Glu Ile Asn Lys Lys Arg Glu Ser Asn 
            20                  25                  30          


Cys Leu Val Glu Arg Ser Asn Gln Val Ser Leu Leu Arg Val Gln Lys 
        35                  40                  45              


Arg His Phe Pro Asp Ala Tyr Gln Ser Phe Thr Asp Thr Thr Thr Lys 
    50                  55                  60                  


Glu Pro Val Pro Asn Ser Gly Arg Ser Ser Trp Ile Lys Leu Ser Leu 
65                  70                  75                  80  


Leu Ala His Met Glu Arg Lys His Phe Pro Pro Lys Asn Asn Ala Ile 
                85                  90                  95      


Phe Gly 
        


<210>  7065
<211>  415
<212>  DNA
<213>  Homosapiens

<400>  7065
cacgctttgg gttgctgtat ggtagtatgc taaaggacag caagaatcac ttgacaattg     60

gtttgtgacc ataatggcat ctataaacag aaccattgaa ataatgaaaa aacatggagt    120

aagcaaacaa catctcctgg aggagataaa caaaaagcgt gaatccaact gcttggtgga    180

acgaagcaat caagtcagct tactgagagt tcaaaagagg cacttcccgg atgcctatca    240

gtcctttact gataccacaa ccaaagagcc tgttcccaac agtggcagga gctcctggat    300

caagctgagt ctccttgctc acatggagag aaagcacttt ccaccaaaaa ataatgccat    360

atttggataa agtgcatctc cagagacaca cggaaataca ttctctttga ttctt         415


<210>  7066
<211>  98
<212>  PRT
<213>  Homosapiens

<400>  7066

Met Ala Ser Ile Asn Arg Thr Ile Glu Ile Met Lys Lys His Gly Val 
1               5                   10                  15      


Ser Lys Gln His Leu Leu Glu Glu Ile Asn Lys Lys Arg Glu Ser Asn 
            20                  25                  30          


Cys Leu Val Glu Arg Ser Asn Gln Val Ser Leu Leu Arg Val Gln Lys 
        35                  40                  45              


Arg His Phe Pro Asp Ala Tyr Gln Ser Phe Thr Asp Thr Thr Thr Lys 
    50                  55                  60                  


Glu Pro Val Pro Asn Ser Gly Arg Ser Ser Trp Ile Lys Leu Ser Leu 
65                  70                  75                  80  


Leu Ala His Met Glu Arg Lys His Phe Pro Pro Lys Asn Asn Ala Ile 
                85                  90                  95      


Phe Gly 
        


<210>  7067
<211>  2520
<212>  DNA
<213>  Homosapiens

<400>  7067
cctgcccgga aggatgcatg gcccggggtc tcctgcacct gagggtgggc gggaggcggc     60

cccgcgggtt gtgttgctgg aaaaaggggt ctcgatccag accccaagag agggttcttg    120

ggtctacttc agggaagaat tggaggcgag tcacagagcg cagtgaagga agcaagttta    180

ttggaatcta ctccgttaga gagtgcaagt cctcagactg caggaggagg aactcccgtc    240

cttcggtagt gtcactactt agaggcagct gtgaggagct gtgattaatc gtggaatgtg    300

ctgatgtgcc cactaaagag ctttgccctt ggagtccagg ctggagtgca atgatgaaat    360

ctcagctgac tgcaacttct gcctcccggg ttcaagtgat tctcctgcct cagcctccca    420

agtaactgag attacaggtg cccacacccg ggtaattttt gtatttttag tagagacagg    480

gtttctccat gtcggtcagg ctggtctcga actcctgacc tcaggtgatc cacctacctc    540

agcctcccaa agtgctgggg ttacaggcat gagccaccgt gcccggccac cattctaatt    600

tcttaatctt gtcttctttc tctggcttca gtggtagata tttattaacc agtttaaaca    660

tgagtcatta tttatatcaa atgtttggat gtataacgta aaatgaacct taatctctgt    720

caaaaaagat actactggga gcatcgtttg gctgggagtc aagatgagat tgagctactt    780

tatgggtgtg gaatgccaag tcagagagat ttgaataagt aacacttcag caatatgaga    840

tctggacagc atccaggagc caaggtccaa gatgctaata ggagtgatgt agctgtccct    900

gaacaaaggt ttgccacagt ttacgagcct cagaggttaa gatgcaaacc agaacaatgc    960

tattggatgt gcaatccatg atgtttcatg gggaggtggg tagatttggg caaccttgcc   1020

ttcagtttac tcctactagc atcaggctct gtccacctga tcagcagagg ctatatggtt   1080

ctattttgtg aaaagatcaa gttggaaatg gaggagtaga ggagaaggtt ggaaatcaga   1140

atcctcccac atgtattctt ccctccattg agacatttta tttgtatata tttattcctg   1200

aaaaaaaaaa aaaaaaaaga gtcccaggat tttttctcct gtgtttttgt cttgtttctt   1260

ctcggtccat gatgccagtt gaggtcatca gtacagcgaa accaaactgg tgagatggga   1320

acaaattatt ctgtcacttt tctagatctt tttatttatt tttttattta ttttttgaga   1380

tggagtctcg ctcttgttgc ccagtctgga gtgcaatggc gagcctgggt tcaagaccag   1440

cctgggtaac atggcgaaac cccttctcta ccaaaaaaat acagtattta gctgggcctg   1500

gtgcatgcct gtagtcccag ctacctgaga ggctgaggtg ggaagatcgc ttgagcccag   1560

gaggtcaagg ctgcaatggg ctgagatcac gccactccag cctaggcaac agagtgaggc   1620

cttgtcaaaa aaaaaaaaga gagagagaga gatacaagcc ttcagagacc ctcatattaa   1680

cttcatggta aatctgcctc tgctcacccc tcccacctgt agcaactaat atcttcattt   1740

ccagatttac tctgaaaaaa ctgtgcaact gcttcacatg tttcctcttg attcactaat   1800

ttgtaactca cttactgaaa ctctgatgaa agaattgagt caaaaaataa atagacctcc   1860

ttcccagccc tggcttgttc agagcatcta ctacagagga gtcttaaggg ttttgtatgc   1920

ttagagttga gagaccaaat agctcctgaa aactgtagct agaggaaatg ccatatggag   1980

acaggccaca aggagaactc aagcccctgt aaaccaaaaa tgaaatattc taagccccca   2040

atttactaaa cagattcaac ctcccacttc agcctcccaa atagctggga ttacaggcgc   2100

atgcaaccat gcccggcaaa tttttgtgtt ttttgtagag atggggtttc gccatgttgg   2160

ccaggctggt cttgaactcc tgacttcaag tgatctgtcc acctcaccct cccaaagtgc   2220

tgggattagt gagccactgc aacagccctc taacacttat ttctgaagtt ttttttcttc   2280

cctccttctc ggaagcccct tcctccctct cttgttgcct taaggtacct tcaccctggc   2340

taggccctat tgttctttta tcggtttttt gtttgtttct ttagcctaca tatgctcttc   2400

cacctgggtt atacaaatgc aaagtacacc ctagttccat gctgggcctt attattaaca   2460

agaactttct gaatctctta agatgtagtg aaagcagata tacataaact atgttgaact   2520


<210>  7068
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  7068

Met Ala Arg Gly Leu Leu His Leu Arg Val Gly Gly Arg Arg Pro Arg 
1               5                   10                  15      


Gly Leu Cys Cys Trp Lys Lys Gly Ser Arg Ser Arg Pro Gln Glu Arg 
            20                  25                  30          


Val Leu Gly Ser Thr Ser Gly Lys Asn Trp Arg Arg Val Thr Glu Arg 
        35                  40                  45              


Ser Glu Gly Ser Lys Phe Ile Gly Ile Tyr Ser Val Arg Glu Cys Lys 
    50                  55                  60                  


Ser Ser Asp Cys Arg Arg Arg Asn Ser Arg Pro Ser Val Val Ser Leu 
65                  70                  75                  80  


Leu Arg Gly Ser Cys Glu Glu Leu 
                85              


<210>  7069
<211>  823
<212>  DNA
<213>  Homosapiens

<400>  7069
cggaaggatg catggcccgg ggtctcctgc acctgagggt gggcgggagg cggccccgcg     60

ggttgtgttg ctggaaaaag gggtctcgat ccagacccca agagagggtt cttgggtcta    120

cttcagggaa gaattggagg cgagtcacag agcgcagtga aggaagcaag tttattggaa    180

tctactccgt tagagagtgc aagtcctcag actgcaggag gaggaactcc cgtccttcgg    240

tagtgtcact acttagaggc agctgtgagg agctgtgatt aatcgtggaa tgtgctgatg    300

tgcccactaa agaggaataa cgccagaaag tgttccagta caaccagaga aagagagtcc    360

atgagaaatc tgcccttgtg aagttggaat cccctcaacc tcaccccgct gacttgaatg    420

aagcgactga gacgggctat gatggagcag atccggttgc tcgaccttct cccttgcacc    480

aacacatgta gttaatagtt actggacatg catattcagt gggttccagg taccaaactt    540

gtattgaatg gtatgtgcca gacaccgtct tgagatctgg agaataaaaa aataaaaaaa    600

taaaaacgag acatccagag cacagtagcc ttgcggtctt cctggaacta gagaaaattc    660

agcccttctg ctccttggga agctatgttt gggaaaaaaa aaaaaagaga gagagagaga    720

ctccaaagag tttgttatta aatttaagtt caaactaggt gtatatagta caaaagttct    780

taccatgcat ttaatcttaa aatgtgctga tatctagaac cct                      823


<210>  7070
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  7070

Met Ala Arg Gly Leu Leu His Leu Arg Val Gly Gly Arg Arg Pro Arg 
1               5                   10                  15      


Gly Leu Cys Cys Trp Lys Lys Gly Ser Arg Ser Arg Pro Gln Glu Arg 
            20                  25                  30          


Val Leu Gly Ser Thr Ser Gly Lys Asn Trp Arg Arg Val Thr Glu Arg 
        35                  40                  45              


Ser Glu Gly Ser Lys Phe Ile Gly Ile Tyr Ser Val Arg Glu Cys Lys 
    50                  55                  60                  


Ser Ser Asp Cys Arg Arg Arg Asn Ser Arg Pro Ser Val Val Ser Leu 
65                  70                  75                  80  


Leu Arg Gly Ser Cys Glu Glu Leu 
                85              


<210>  7071
<211>  1088
<212>  DNA
<213>  Homosapiens

<400>  7071
attttcctgc ccggaaggat gcatggcccg gggtctcctg cacctgaggg tgggcgggag     60

gcggccccgc gggttgtgtt gctggaaaaa ggggtctcga tccagacccc aagagagggt    120

tcttgggtct acttcaggga agaattggag gcgagtcaca gagcgcagtg aaggaagcaa    180

gtttattgga atctactccg ttagagagtg caagtcctca gactgcagga ggaggaactc    240

ccgtccttcg gtagtgtcac tacttagagg cagctgtgag gagctgtgat taatcgtgga    300

atgtgctgat gtgcccacta aagatgcctg gtaagcagtg gctcctctaa caagtgggca    360

gcttggaact gggaacgaga gagccaccga aacagaatga gggagacaaa gaagtgggca    420

tcacccttaa ctccacaagg gcttcccaag ggcgctgtac cgtacgcagg cccaggacga    480

actttatttc tcgccccagc atcgctgtcc ttgtcggtga gaccctggct ttagggcaga    540

caggaccacg tttcataagt tcatgctgtc ccagcagagg aataacgcca gaaagtgttc    600

cagtacaacc agagaaagag agtccatgag aaatctgccc ttgtgaagtt ggaatcccct    660

caacctcacc ccgctgactt gaatgaagcg actgagacgg gctatgatgg agcagatccg    720

gttgctcgac cttctccctt gcaccaacac atgtagttaa tagttactgg acatgcatat    780

tcagtgggtt ccaggtacca aacttgtatt gaatggtatg tgccagacac cgtcttgaga    840

tctggagaat aaaaaaataa aaaaataaaa acgagacatc cagagcacag tagccttgcg    900

gtcttcctgg aactagagaa aattcagccc ttctgctcct tgggaagcta tgtttgggaa    960

aaaaaaaaaa agagagagag agagactcca aagagtttgt tattaaattt aagttcaaac   1020

taggtgtata tagtacaaaa gttcttacca tgcatttaat cttaaaatgt gctgatatct   1080

agaaccct                                                            1088


<210>  7072
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  7072

Met Ala Arg Gly Leu Leu His Leu Arg Val Gly Gly Arg Arg Pro Arg 
1               5                   10                  15      


Gly Leu Cys Cys Trp Lys Lys Gly Ser Arg Ser Arg Pro Gln Glu Arg 
            20                  25                  30          


Val Leu Gly Ser Thr Ser Gly Lys Asn Trp Arg Arg Val Thr Glu Arg 
        35                  40                  45              


Ser Glu Gly Ser Lys Phe Ile Gly Ile Tyr Ser Val Arg Glu Cys Lys 
    50                  55                  60                  


Ser Ser Asp Cys Arg Arg Arg Asn Ser Arg Pro Ser Val Val Ser Leu 
65                  70                  75                  80  


Leu Arg Gly Ser Cys Glu Glu Leu 
                85              


<210>  7073
<211>  1991
<212>  DNA
<213>  Homosapiens

<400>  7073
gccgcgcggc gcgggggagg agaccttcat ctgttcacgc ggtagcgcgg attgcggttc     60

gcggcgcgcg ccaccgggga aggagcggtg ggccgagggg ttggaggtgg ggccccagga    120

ggacctcggg ctgtgggccg ggagagcgga gtcggggagt ggggcggggg agcgaggtgg    180

cgccggggag cctgggatat ggcgcggcca gacgatgagg agggggcggc ggtggcgccc    240

ggacacccgc tcgcgaaagg atacctcccg ttgccgaggg gcgcgcccgt tgggaaggag    300

agcgtggagc tgcagaacgg gcccaaagcg ggcaccttcc cggtgaatgg ggccccccgg    360

gacagcctcg ctgccgcctc gggagttctg ggcgggcctc agactccact ggccccagaa    420

gaggagaccc aggcccggct gctgcctgcg ggcgcgggag ctgagacccc gggggccgag    480

agcagcccgc tgccccttac ggcgctctcc ccgcggcgct tcgtggtgct cctgatcttc    540

agcctgtact cgctggtcaa cgcctttcag tggatccagt acagcatcat tagcaacgtc    600

ttcgagggct tctacggtgt caccttgctg cacatcgact ggctgtccat ggtgtacatg    660

ctggcctacg tgcccctcat cttcccggcc acctggctgc tggacaccag aggcctgcgg    720

ctcaccgccc tgctgggctc cggcctcaac tgcctgggtg cctggatcaa gtgcggcagt    780

gtgcagcagc atctcttctg ggtcaccatg ttgggccagt gcttgtgctc ggtggcccag    840

gtgttcatcc tgggcttgcc ctcccgcatc gcctcagtgt ggtttgggcc caaagaggtg    900

tccacagctt gtgccaccgc cgtgctgggc aatcagcttg gaactgcagt tggctttttg    960

ctaccaccag ttttagtacc caacacacag aatgacacaa atctcctggc ttgtaatatc   1020

agcaccatgt tttatggaac atcagctgtt gccacacttt tatttatttt aacagcaatt   1080

gccttcaaag aaaaacctcg gtatccacca agtcaggctc aagcagctct tcaagacagt   1140

ccccctgaag agtactccta taagaaatca ataagaaacc tgtttaaaaa cattcctttt   1200

gtccttctgt tgatcactta tggtatcatg actggtgcct tttattcagt ctcaacgtta   1260

ttaaatcaaa tgatattgac atattatgag ggagaagaag tcaatgctgg aaggattggg   1320

ctaacgctag tagtagctgg aatggtgggc tctattcttt gtggcttatg gctggattat   1380

actaaaacat acaaacagac tactctgata gtttatattt tgtcttttat tggaatggtt   1440

atctttactt tcacattgga ccttagatat attatcatcg tgtttgttac tggaggggtg   1500

cttggcttct tcatgactgg ttacctccct ttgggttttg aatttgctgt tgaaatcact   1560

taccctgaat ctgaaggtac ttcatctggt cttcttaatg cttctgcaca gatatttgga   1620

attttgttca cattggctca aggaaagctc acatcagact atggtcctaa ggcagggaac   1680

atttttctct gtgtctggat gtttataggc atcatattaa cagcattaat caagtctgat   1740

ctgcgaagac acaacataaa tataggaatt acaaatgttg atgttaaagc tataccagct   1800

gacagtccca cagaccaaga accaaaaacg gttatgttgt ccaagcagtc agaatcagca   1860

atttgaagag aaaggcaaag ttactgtcct gtagtaattg gggacaatgt gatcatcctt   1920

ggagagagat gtgagcacca aggctgggtt tgtatgtggt gggggaataa acacacttac   1980

ttgaaaatta c                                                        1991


<210>  7074
<211>  555
<212>  PRT
<213>  Homosapiens

<400>  7074

Met Ala Arg Pro Asp Asp Glu Glu Gly Ala Ala Val Ala Pro Gly His 
1               5                   10                  15      


Pro Leu Ala Lys Gly Tyr Leu Pro Leu Pro Arg Gly Ala Pro Val Gly 
            20                  25                  30          


Lys Glu Ser Val Glu Leu Gln Asn Gly Pro Lys Ala Gly Thr Phe Pro 
        35                  40                  45              


Val Asn Gly Ala Pro Arg Asp Ser Leu Ala Ala Ala Ser Gly Val Leu 
    50                  55                  60                  


Gly Gly Pro Gln Thr Pro Leu Ala Pro Glu Glu Glu Thr Gln Ala Arg 
65                  70                  75                  80  


Leu Leu Pro Ala Gly Ala Gly Ala Glu Thr Pro Gly Ala Glu Ser Ser 
                85                  90                  95      


Pro Leu Pro Leu Thr Ala Leu Ser Pro Arg Arg Phe Val Val Leu Leu 
            100                 105                 110         


Ile Phe Ser Leu Tyr Ser Leu Val Asn Ala Phe Gln Trp Ile Gln Tyr 
        115                 120                 125             


Ser Ile Ile Ser Asn Val Phe Glu Gly Phe Tyr Gly Val Thr Leu Leu 
    130                 135                 140                 


His Ile Asp Trp Leu Ser Met Val Tyr Met Leu Ala Tyr Val Pro Leu 
145                 150                 155                 160 


Ile Phe Pro Ala Thr Trp Leu Leu Asp Thr Arg Gly Leu Arg Leu Thr 
                165                 170                 175     


Ala Leu Leu Gly Ser Gly Leu Asn Cys Leu Gly Ala Trp Ile Lys Cys 
            180                 185                 190         


Gly Ser Val Gln Gln His Leu Phe Trp Val Thr Met Leu Gly Gln Cys 
        195                 200                 205             


Leu Cys Ser Val Ala Gln Val Phe Ile Leu Gly Leu Pro Ser Arg Ile 
    210                 215                 220                 


Ala Ser Val Trp Phe Gly Pro Lys Glu Val Ser Thr Ala Cys Ala Thr 
225                 230                 235                 240 


Ala Val Leu Gly Asn Gln Leu Gly Thr Ala Val Gly Phe Leu Leu Pro 
                245                 250                 255     


Pro Val Leu Val Pro Asn Thr Gln Asn Asp Thr Asn Leu Leu Ala Cys 
            260                 265                 270         


Asn Ile Ser Thr Met Phe Tyr Gly Thr Ser Ala Val Ala Thr Leu Leu 
        275                 280                 285             


Phe Ile Leu Thr Ala Ile Ala Phe Lys Glu Lys Pro Arg Tyr Pro Pro 
    290                 295                 300                 


Ser Gln Ala Gln Ala Ala Leu Gln Asp Ser Pro Pro Glu Glu Tyr Ser 
305                 310                 315                 320 


Tyr Lys Lys Ser Ile Arg Asn Leu Phe Lys Asn Ile Pro Phe Val Leu 
                325                 330                 335     


Leu Leu Ile Thr Tyr Gly Ile Met Thr Gly Ala Phe Tyr Ser Val Ser 
            340                 345                 350         


Thr Leu Leu Asn Gln Met Ile Leu Thr Tyr Tyr Glu Gly Glu Glu Val 
        355                 360                 365             


Asn Ala Gly Arg Ile Gly Leu Thr Leu Val Val Ala Gly Met Val Gly 
    370                 375                 380                 


Ser Ile Leu Cys Gly Leu Trp Leu Asp Tyr Thr Lys Thr Tyr Lys Gln 
385                 390                 395                 400 


Thr Thr Leu Ile Val Tyr Ile Leu Ser Phe Ile Gly Met Val Ile Phe 
                405                 410                 415     


Thr Phe Thr Leu Asp Leu Arg Tyr Ile Ile Ile Val Phe Val Thr Gly 
            420                 425                 430         


Gly Val Leu Gly Phe Phe Met Thr Gly Tyr Leu Pro Leu Gly Phe Glu 
        435                 440                 445             


Phe Ala Val Glu Ile Thr Tyr Pro Glu Ser Glu Gly Thr Ser Ser Gly 
    450                 455                 460                 


Leu Leu Asn Ala Ser Ala Gln Ile Phe Gly Ile Leu Phe Thr Leu Ala 
465                 470                 475                 480 


Gln Gly Lys Leu Thr Ser Asp Tyr Gly Pro Lys Ala Gly Asn Ile Phe 
                485                 490                 495     


Leu Cys Val Trp Met Phe Ile Gly Ile Ile Leu Thr Ala Leu Ile Lys 
            500                 505                 510         


Ser Asp Leu Arg Arg His Asn Ile Asn Ile Gly Ile Thr Asn Val Asp 
        515                 520                 525             


Val Lys Ala Ile Pro Ala Asp Ser Pro Thr Asp Gln Glu Pro Lys Thr 
    530                 535                 540                 


Val Met Leu Ser Lys Gln Ser Glu Ser Ala Ile 
545                 550                 555 


<210>  7075
<211>  3882
<212>  DNA
<213>  Homosapiens

<400>  7075
tcacgcggta gcgcggattg cggttcgcgg cgcgcgccac cggggaagga gcggtgggcc     60

gaggggttgg aggtggggcc ccaggaggac ctcgggctgt gggccgggag agcggagtcg    120

gggagtgggg cgggggagcg aggtggcgcc ggggagcctg ggatatggcg cggccagacg    180

atgaggaggg ggcggcggtg gcgcccggac acccgctcgc gaaaggatac ctcccgttgc    240

cgaggggcgc gcccgttggg aaggagagcg tggagctgca gaacgggccc aaagcgggca    300

ccttcccggt gaatggggcc ccccgggaca gcctcgctgc cgcctcggga gttctgggcg    360

ggcctcagac tccactggcc ccagaagagg agacccaggc ccggctgctg cctgcgggcg    420

cgggagctga gaccccgggg gccgagagca gcccgctgcc ccttacggcg ctctccccgc    480

ggcgcttcgt ggtgctcctg atcttcagcc tgtactcgct ggtcaacgcc tttcagtgga    540

tccagtacag catcattagc aacgtcttcg agggcttcta cggtgtcacc ttgctgcaca    600

tcgactggct gtccatggtg tacatgctgg cctacgtgcc cctcatcttc ccggccacct    660

ggctgctgga caccagaggc ctgcggctca ccgccctgct gggctccggc ctcaactgcc    720

tgggtgcctg gatcaagtgc ggcagtgtgc agcagcatct cttctgggtc accatgttgg    780

gccagtgctt gtgctcggtg gcccaggtgt tcatcctggg cttgccctcc cgcatcgcct    840

cagtgtggtt tgggcccaaa gaggtgtcca cagcttgtgc caccgccgtg ctgggcaatc    900

agcttggaac tgcagttggc tttttgctac caccagtttt agtacccaac acacagaatg    960

acacaaatct cctggcttgt aatatcagca ccatgtttta tggaacatca gctgttgcca   1020

cacttttatt tattttaaca gcaattgcct tcaaagaaaa acctcggtat ccaccaagtc   1080

aggctcaagc agctcttcaa gacagtcccc ctgaagagta ctcctataag aaatcaataa   1140

gaaacctgtt taaaaacatt ccttttgtcc ttctgttgat cacttatggt atcatgactg   1200

gtgcctttta ttcagtctca acgttattaa atcaaatgat attgacatat tatgagggag   1260

aagaagtcaa tgctggaagg attgggctaa cgctagtagt agctggaatg gtgggctcta   1320

ttctttgtgg cttatggctg gattatacta aaacatacaa acagactact ctgatagttt   1380

atattttgtc ttttattgga atggttatct ttactttcac attggacctt agatatatta   1440

tcatcgtgtt tgttactgga ggggtgcttg gcttcttcat gactggttac ctccctttgg   1500

gttttgaatt tgctgttgaa atcacttacc ctgaatctga aggtacttca tctggtcttc   1560

ttaatgcttc tgcacagata tttggaattt tgttcacatt ggctcaagga aagctcacat   1620

cagactatgg tcctaaggca gggaacattt ttctctgtgt ctggatgttt ataggcatca   1680

tattaacagc attaatcaag tctgatctgc gaagacacaa cataaatata ggaattacaa   1740

atgttgatgt taaagctata ccagctgaca gtcccacaga ccaagaacca aaaacggtta   1800

tgttgtccaa gcagtcagaa tcagcaattt gaagagaaag gcaaagttac tgtcctgtag   1860

taattgggga caatgtgatc atccttggag agagatgtga gcaccaaggc tgggtttgta   1920

tgtggtgggg gaataaacac acttacttga aaattaccat atgaactcta aatgcataat   1980

tattattttg cttaattgtt aaattaaggg aaattttctt aaaattcttc tgtttacatc   2040

atgttaacac tactgtttat ctaattagta tccggttttt agtctcatat tgtatctgaa   2100

agtaagcttc ttgacgttta ctttttaaaa gtcgatgttt ttcttttttg tagaaaatgg   2160

aagcttagaa tactttttaa agtgataata tggggtgttc agtccccata agatataata   2220

gttcatgcag tttatatatt aaagtatcca gtggaactaa atgtacaata tattcctaat   2280

tggctgcctt tttcactgtg ctgaccagct gttcaagcca cttcagtttg agtacaacat   2340

accaacatga cactactcac ccacaaagga cagcattggg atcaggcttt cagatgacct   2400

ctaagatttt tcccatttat tgtactcttg ttacaaagta ctttttaaca catgcagtca   2460

atggctataa aaactattct gtgtacagat tctacccaga ctttggtctt agaattatgt   2520

tctaattaag gagcctggtt acaggttcat tctgtcttga gttcttttct gtgctgcctt   2580

tctatcatgg ataaatgcta acgctgtatt ttttcactcc aacttgagat agagtagttt   2640

tgtacccatt gccttttttt tcttttaaac tctctttttt tttttttcct gatgtgtaac   2700

tttctagtaa gataatttca tcatgtatgt tactggctat ttcatgattt catgtatcac   2760

atcgtatatt ttgccttgaa gattcctgaa ataaggaaat ctataataac ttcagatagc   2820

ctacatgtcc ccatttagtg gagacctctt gaatgctatt tgaattctgc agtatcattt   2880

ttatgaccat tctcctttga ggaatactat gcccaggtac atgctctatc agtgtgccgg   2940

gagagtggat tcttttcttc actgcagagt catcacactg ttagaatagt ctgctctttt   3000

acatgctcag gtagggaaaa taggaccaaa tatatttcca cagtgcctac cactgtgtca   3060

tgtttacagt gagagtttaa atattgttga tgtcctgact ctgtgagctc atagggagta   3120

tcttcatagt aatgacattt gatcagccat aaaatttaca ttatgttcat atgcacccaa   3180

aaaagctagt caggtaatga atacccttga agtgaatagc aattttgatt taggcagtgt   3240

gttaggccat ccttgcattg ctataaagaa atatttaggc tgggcgtggt ggctcacgcc   3300

tgtaatccca gcactttggg aggctgaagc gtgtggatca cctgaggtca ggagttcaag   3360

accagcctgg ccaacatggt aaaaccccat ctctactaaa aaaaaaaaaa aaaaaaaaaa   3420

aaaaaaaaaa ggccaggcgc agtgctgtgg ctcatgcctg taatctcagc actttgggag   3480

gccaaggcag gtggatcaca aagtcaggag ttcaaaacca gcctggccaa gatggtgaaa   3540

ccccatctct actaaaaata caaaaattag cgcagtggca ggcgcctgta atcccagcta   3600

ctcaggaggc tgaggcagga gaatcgcttg aatgcgaatg gcagaggttg cagtgagcga   3660

aaatcacact actgcactcc agcctgggag ataaagtgag actgtctcaa ataaataaat   3720

aaataaataa ataaataaat aaataaataa ataaaacctg aggttgagca cgatggctca   3780

cacctatagt cccagcactt tgggaggctg aggtgggtgg atcatttgag gccaggagtt   3840

gaagaccagt ctggccaaca tggcaaaacc ccatctctac ta                      3882


<210>  7076
<211>  555
<212>  PRT
<213>  Homosapiens

<400>  7076

Met Ala Arg Pro Asp Asp Glu Glu Gly Ala Ala Val Ala Pro Gly His 
1               5                   10                  15      


Pro Leu Ala Lys Gly Tyr Leu Pro Leu Pro Arg Gly Ala Pro Val Gly 
            20                  25                  30          


Lys Glu Ser Val Glu Leu Gln Asn Gly Pro Lys Ala Gly Thr Phe Pro 
        35                  40                  45              


Val Asn Gly Ala Pro Arg Asp Ser Leu Ala Ala Ala Ser Gly Val Leu 
    50                  55                  60                  


Gly Gly Pro Gln Thr Pro Leu Ala Pro Glu Glu Glu Thr Gln Ala Arg 
65                  70                  75                  80  


Leu Leu Pro Ala Gly Ala Gly Ala Glu Thr Pro Gly Ala Glu Ser Ser 
                85                  90                  95      


Pro Leu Pro Leu Thr Ala Leu Ser Pro Arg Arg Phe Val Val Leu Leu 
            100                 105                 110         


Ile Phe Ser Leu Tyr Ser Leu Val Asn Ala Phe Gln Trp Ile Gln Tyr 
        115                 120                 125             


Ser Ile Ile Ser Asn Val Phe Glu Gly Phe Tyr Gly Val Thr Leu Leu 
    130                 135                 140                 


His Ile Asp Trp Leu Ser Met Val Tyr Met Leu Ala Tyr Val Pro Leu 
145                 150                 155                 160 


Ile Phe Pro Ala Thr Trp Leu Leu Asp Thr Arg Gly Leu Arg Leu Thr 
                165                 170                 175     


Ala Leu Leu Gly Ser Gly Leu Asn Cys Leu Gly Ala Trp Ile Lys Cys 
            180                 185                 190         


Gly Ser Val Gln Gln His Leu Phe Trp Val Thr Met Leu Gly Gln Cys 
        195                 200                 205             


Leu Cys Ser Val Ala Gln Val Phe Ile Leu Gly Leu Pro Ser Arg Ile 
    210                 215                 220                 


Ala Ser Val Trp Phe Gly Pro Lys Glu Val Ser Thr Ala Cys Ala Thr 
225                 230                 235                 240 


Ala Val Leu Gly Asn Gln Leu Gly Thr Ala Val Gly Phe Leu Leu Pro 
                245                 250                 255     


Pro Val Leu Val Pro Asn Thr Gln Asn Asp Thr Asn Leu Leu Ala Cys 
            260                 265                 270         


Asn Ile Ser Thr Met Phe Tyr Gly Thr Ser Ala Val Ala Thr Leu Leu 
        275                 280                 285             


Phe Ile Leu Thr Ala Ile Ala Phe Lys Glu Lys Pro Arg Tyr Pro Pro 
    290                 295                 300                 


Ser Gln Ala Gln Ala Ala Leu Gln Asp Ser Pro Pro Glu Glu Tyr Ser 
305                 310                 315                 320 


Tyr Lys Lys Ser Ile Arg Asn Leu Phe Lys Asn Ile Pro Phe Val Leu 
                325                 330                 335     


Leu Leu Ile Thr Tyr Gly Ile Met Thr Gly Ala Phe Tyr Ser Val Ser 
            340                 345                 350         


Thr Leu Leu Asn Gln Met Ile Leu Thr Tyr Tyr Glu Gly Glu Glu Val 
        355                 360                 365             


Asn Ala Gly Arg Ile Gly Leu Thr Leu Val Val Ala Gly Met Val Gly 
    370                 375                 380                 


Ser Ile Leu Cys Gly Leu Trp Leu Asp Tyr Thr Lys Thr Tyr Lys Gln 
385                 390                 395                 400 


Thr Thr Leu Ile Val Tyr Ile Leu Ser Phe Ile Gly Met Val Ile Phe 
                405                 410                 415     


Thr Phe Thr Leu Asp Leu Arg Tyr Ile Ile Ile Val Phe Val Thr Gly 
            420                 425                 430         


Gly Val Leu Gly Phe Phe Met Thr Gly Tyr Leu Pro Leu Gly Phe Glu 
        435                 440                 445             


Phe Ala Val Glu Ile Thr Tyr Pro Glu Ser Glu Gly Thr Ser Ser Gly 
    450                 455                 460                 


Leu Leu Asn Ala Ser Ala Gln Ile Phe Gly Ile Leu Phe Thr Leu Ala 
465                 470                 475                 480 


Gln Gly Lys Leu Thr Ser Asp Tyr Gly Pro Lys Ala Gly Asn Ile Phe 
                485                 490                 495     


Leu Cys Val Trp Met Phe Ile Gly Ile Ile Leu Thr Ala Leu Ile Lys 
            500                 505                 510         


Ser Asp Leu Arg Arg His Asn Ile Asn Ile Gly Ile Thr Asn Val Asp 
        515                 520                 525             


Val Lys Ala Ile Pro Ala Asp Ser Pro Thr Asp Gln Glu Pro Lys Thr 
    530                 535                 540                 


Val Met Leu Ser Lys Gln Ser Glu Ser Ala Ile 
545                 550                 555 


<210>  7077
<211>  590
<212>  DNA
<213>  Homosapiens

<400>  7077
gctgccacca ctcgtcactg agtcctctcg tctgagcctg tctcttgaag cagtcagtca     60

aaatcaactg caagcagcca tcatcagttt ggaagaagct ttgggaagcc ttcaaagaaa    120

aacctcggta tccaccaagt caggctcaag cagctcttca agacagtccc cctgaagagt    180

actcctataa gaaatcaata agaaacctgt ttaaaaacat tccttttgtc cttctgttga    240

tcacttatgg tatcatgact ggtgcctttt attcagtctc aacgttatta aatcaaatga    300

tattgacata ttatgaggga gaagaagtca atgctggaag gattgggcta acgctagtag    360

tagctggaat ggtgggctct attctttgtg gcttatggct ggattatact aaaacataca    420

agtaagtgaa agtaaataca tgtatggtgt ataaccaaag gtattttgat tttaaaggac    480

aatttgcttt ttatttcaag aaatttaaaa catgttatta cttaaagata cggattctaa    540

acactagtag gttctcttca cttaacaagt gtttcttttt tttttttttt               590


<210>  7078
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  7078

Met Thr Gly Ala Phe Tyr Ser Val Ser Thr Leu Leu Asn Gln Met Ile 
1               5                   10                  15      


Leu Thr Tyr Tyr Glu Gly Glu Glu Val Asn Ala Gly Arg Ile Gly Leu 
            20                  25                  30          


Thr Leu Val Val Ala Gly Met Val Gly Ser Ile Leu Cys Gly Leu Trp 
        35                  40                  45              


Leu Asp Tyr Thr Lys Thr Tyr Lys 
    50                  55      


<210>  7079
<211>  3303
<212>  DNA
<213>  Homosapiens

<400>  7079
acagaataac attcgagaat gggacatgga atgaggcgac ggccccagca agccccagca     60

gccccagccc cagccccagg cccagcagca gcagcagcag cccctgctct cccgccgccc    120

ggagaggctc tgcagccatg aagccaaccg tcccgaggca ccgccggtaa gcagggagcc    180

tccgcggagc tcccgccgcc gctccccctt ggtgagtcct gccgcagcga gaggcatgga    240

gaaggccgcc cccgcggggc gctgatcccc tcgccgcgcc cgcgcgcaca cgccccccgc    300

cgccgccgcc gctgccgccg ccgcgcgccc ccagtacctc gctccccgcc caggccccac    360

catgaccggc tccgcggccg acactcaccg ctgcccccac cccaaaggcg ccaaaggcac    420

ccggtcccgg agcagccacg cgcggcccgt gagcctcgcc accagcgggg gctcagagga    480

ggaggacaaa gacggcgggg tgctgttcca cgtcaacaag agcggcttcc ccatcgacag    540

ccacacctgg gagcgcatgt ggatgcacgt ggccaaggtg caccctaagg ggggagaaat    600

ggtgggcgcc atcaggaacg ccgccttctt ggcaaagcct tcaatacccc aggtcccaaa    660

ctacaggctg tcgatgacga tcccagactg gctccaggcg atccagaatt acatgaagac    720

cctacaatat aatcacacag ggacccagtt ctttgaaatt aggaaaatga gaccgctgag    780

tgggttaatg gaaacagcaa aagaaatgac ccgagagtcc ttgcctatca aatgccttga    840

agctgtcatc ctgggcataa cccacagcta aaacaagggt ctagcttctc ccacactttc    900

tgttccattt ttcaccagac tcccggctct tcagcctgag aggaatatgg tgcagagaaa    960

ctgtgatggc atcgacatat tggtggtgat gaccacctcc cttacacaat agtctcatcc   1020

ctgcacaatt ttatacattc gagcatcatg ccattggaat cacccacaac cctttgaaat   1080

tgtggggata gacccaggaa cagcctttga gcctgatctg ccacaatcag atagaagagc   1140

aaagatgctc cgaagtccta tgggatggat ggctgtaagg gacagtggaa aaggaaacac   1200

tgcaagacag gagcttgaga gatggtccca ggcaagatca gttaggtcct tgagcgctgt   1260

gctgagaaat gacttttttc caaaaggcaa tgggcaaccc agatgaaagc tctgaagcag   1320

aggtgtggca tgcttaggta tatgctctag agaggtagtt ctccaaagca caggctgaag   1380

gacagattgg gaaaggctgg gctggatcag caaagcccgt tgggagctgt tacatgaggg   1440

aatggtgagg ctagactcat ggccctgggg atgggaatgg atttcaggga atggttttaa   1500

gagctatcaa ggagatagaa tgtataggac ttgcaggcca accagacgca ggagttaatg   1560

aggaaggagt caacgtctcc aggtttctga attgggcaat cgactgcggg attagctgga   1620

ggaatgagag tggcagagaa aggatatgcg tcaatgcaga cctgaactaa gacagtgcca   1680

gtgaaggtgg agggaaggga tggaggcata catcatcacc accactaggg gactgcttag   1740

atgggaggag ttattggaga aaggcagtga ctccacattt ctggcttgca tgataatgcc   1800

acaagggaag aacttcaagg agaggatcgg atttagggaa agatgagctc agatttggac   1860

atgtgaaatt tgaggtgcct tgtgggatgt cggaatgagg tatttgcaat gtggagctca   1920

caggggaatc tgcactggaa atgcgaattt aggagctgtg attaggaggt tgtgcttact   1980

gttcaataag tgaaaggaga aaaagatcaa agatgaaatc agtatttttt ggtctagttt   2040

ggcacaaaga gcccatgaaa gagacttaag aaggaaagag aggtagaaag aaaaccagga   2100

gagaaagggg atggagaggt cagtggaagg acatgtggct cagaattaga ctggggacag   2160

gaggattggt ctagtctgtt ttctgggtct cctggacatc tttgtgggaa ggagaatctc   2220

tgtgcctctc tgcagtctgt ggaacacttg cagccctgat ctgaaaccag attgaccaca   2280

ggtgccttgg ctgacatttg aaaaatggaa acttgaacct tactgaggcc cctccccaac   2340

cctcttgtca tcctcctccc tgtttcccac aaaggagatg aaacatgtgc ctggggaacc   2400

cagcaggaag ctgggaatgg gggtcggggc agcagatggc tcagggcccc aactctttag   2460

tggcaggagt cagccacagc tgttcagcga agcctcctgc aagtttaatg ggggcagatg   2520

attggctggg gatttgctgg tggaagagat caacgaaggg gaacacaagc ccaggccctt   2580

catggggtag acaagctaac ttcagactct ttgttgaggg gtgtctgagt gcctctggat   2640

ttaggtcatt gaaatgacca cctcccttac acaatagtct catccctgca caattttata   2700

catttgcgca tcatgccact ggaatcaccc acgacctttt ggaattgtgg ggatagaccc   2760

aggaacagcc tttgagcctg tccaaatcag agacagtgtg ctcgtggttt tcctttgttc   2820

ttatccttct gacatttcag aaaagtgcag gaaggtggag agcttcagtt cacgctgctg   2880

aactcaggga aatttgactc ttgcacacag acaggaaaca cagatccgaa ttcttcttct   2940

tttttttctt tttttgagac ggagtctcgg tctatcgcac cactgcactc cagcctgggt   3000

gacagagtga gactgtgtct caaaaaaatg aaaaaaaaaa gaccaccatt cctccccaga   3060

aatgaaaccc catacccgtt aaaaagtact ccccatttcc cccctccagc ccctgcccac   3120

caccgttcta ctctctgtct gtatgcactt gctactccag gtaccgcaga tgagtggaat   3180

cataccatat ttgtcctttt gtattaggct gatttcactc agcatgtctt caaggctcat   3240

tctgcacatt gcagaatttc cctcccttat gaggctgaat aaattctatt acatgtatac   3300

act                                                                 3303


<210>  7080
<211>  169
<212>  PRT
<213>  Homosapiens

<400>  7080

Met Thr Gly Ser Ala Ala Asp Thr His Arg Cys Pro His Pro Lys Gly 
1               5                   10                  15      


Ala Lys Gly Thr Arg Ser Arg Ser Ser His Ala Arg Pro Val Ser Leu 
            20                  25                  30          


Ala Thr Ser Gly Gly Ser Glu Glu Glu Asp Lys Asp Gly Gly Val Leu 
        35                  40                  45              


Phe His Val Asn Lys Ser Gly Phe Pro Ile Asp Ser His Thr Trp Glu 
    50                  55                  60                  


Arg Met Trp Met His Val Ala Lys Val His Pro Lys Gly Gly Glu Met 
65                  70                  75                  80  


Val Gly Ala Ile Arg Asn Ala Ala Phe Leu Ala Lys Pro Ser Ile Pro 
                85                  90                  95      


Gln Val Pro Asn Tyr Arg Leu Ser Met Thr Ile Pro Asp Trp Leu Gln 
            100                 105                 110         


Ala Ile Gln Asn Tyr Met Lys Thr Leu Gln Tyr Asn His Thr Gly Thr 
        115                 120                 125             


Gln Phe Phe Glu Ile Arg Lys Met Arg Pro Leu Ser Gly Leu Met Glu 
    130                 135                 140                 


Thr Ala Lys Glu Met Thr Arg Glu Ser Leu Pro Ile Lys Cys Leu Glu 
145                 150                 155                 160 


Ala Val Ile Leu Gly Ile Thr His Ser 
                165                 


<210>  7081
<211>  4298
<212>  DNA
<213>  Homosapiens

<400>  7081
acagaataac attcgagaat gggacatgga atgaggcgac ggccccagca agccccagca     60

gccccagccc cagccccagg cccagcagca gcagcagcag cccctgctct cccgccgccc    120

ggagaggctc tgcagccatg aagccaaccg tcccgaggca ccgccggtaa gcagggagcc    180

tccgcggagc tcccgccgcc gctccccctt ggtgagtcct gccgcagcga gaggcatgga    240

gaaggccgcc cccgcggggc gctgatcccc tcgccgcgcc cgcgcgcaca cgccccccgc    300

cgccgccgcc gctgccgccg ccgcgcgccc ccagtacctc gctccccgcc caggccccac    360

catgaccggc tccgcggccg acactcaccg ctgcccccac cccaaaggcg ccaaaggcac    420

ccggtcccgg agcagccacg cgcggcccgt gagcctcgcc accagcgggg gctcagagga    480

ggaggacaaa gacggcgggg tgctgttcca cgtcaacaag agcggcttcc ccatcgacag    540

ccacacctgg gagcgcatgt ggatgcacgt ggccaaggtg caccctaagg ggggagaaat    600

ggtgggcgcc atcaggaacg ccgccttctt ggcaaagcct tcaatacccc aggtcccaaa    660

ctacaggctg tcgatgacga tcccagactg gctccaggcg atccagaatt acatgaagac    720

cctacactac ttaaccaatg ggcagccttc cattgagcgg ttccccatca gctttaaaac    780

ctacttctca ggaaactact ttcaccacgt tgtgctgggg atttactgca atggccgcta    840

tggctcattg ggcatgagcc gcagggctga gctgatggac aagccattga cttttcggac    900

tctgagtgac ctcatctttg actttgagga ctcttacaag aaatacctgc acacagtcaa    960

gaaggtcaag attgggctgt acgtccccca tgagcctcat agcttccagc ccattgagtg   1020

gaagcagctg gtcctcaacg tctcaaagat gctgagggct gacataagga aggagctgga   1080

gaaatatgcc agggacatga gaatgaagat cctgaaacct gcaagtgccc actctccgac   1140

ccaagtgaga agccggggaa aatccctgtc ccccagaagg agacaggcaa gccccccgag   1200

gaggctcggc cggcgagaga agtcgcctgc actgcctgaa aagaaggtgg ctgatctgag   1260

cactctgaat gaagtgggct atcaaatccg aatttagcca agccataccg gccagcaaga   1320

gggtttctgt ggtgcttctc tctgcacttt acccagcatc ttcaggagga actgcaacta   1380

tttattaaga acttgtgaat tttattttta aggattcacc tggaaataga atctgagtgg   1440

gtggtaacca ttagctttaa aaaattcact aaaaggcacc atgaaaaggc tgaagtaata   1500

agccccactg gggttggact atgtccctca ctcaagatct taaggataac cgtaactgaa   1560

gttttatatt tttccattta cctactttct tttacttgct ttgaacatta tgcctcacca   1620

atagtaaatg ttcatgaaat aatctcttga acttttggta tagtaaggta actctaacag   1680

tattactgtc tttttcagca ataacagaaa gcaaaaatgg gtgggttttt tttaagcagt   1740

tattacctca gcattttgac atcagatatg caaacttaat ggcgttttgt ttttttatat   1800

tctatttgta ttctttcccc agtatttccc atggggatct ccacaagttt ggagtttttt   1860

cctggtgcac acacgtgagg agatttaagg tactatatgc aagtgtttta ctaaaaagca   1920

ctgaaattct tctggcaata caagaaccat tttcaggatc ttggagttac ttccttctta   1980

atctttctta aagcattcac tgatgttttt gttttttcaa aatgaaacaa aaatatcaca   2040

ttgagaagct agtctatgtt ctgtcactaa catttaaact ttgcagactc taacaaaaag   2100

cacaagaggt cacgtactat tatacaaatt tagcggtact ggatttacct ctgacattaa   2160

cacactcagg cagagaccag gagtgatcag caggtcttca gaaccaaaaa acctttctgt   2220

tcacatttca tctgattttt aaactgaggc aggctttgat tcttctgaag gatgccaaga   2280

atcaaactaa gggaggactc actgttaaag atgtgttctg atgtcttata ttaagaccaa   2340

atgtgacatg atgtgattat cttccagtac tttgctttta ggtaccattt catgacattt   2400

taggaatgag tattggaaaa tataaagaat tagaaaagca gcactttttt tttaatggaa   2460

aagtcttcgg tccagtgtta caccttatag tgtaattcag tccctaagca cagaatgaat   2520

gtctggcctg catatggtag ttacagtgta acctctggct gcagaccaca caggacaacc   2580

ctaacagcct agtcttgtat ggtgtaaata tcaagagtac agcttcaatt tcatttgctt   2640

tatcttagca acaatgccaa ctcaggagag cagacggccg atttcagtga agtctggtag   2700

tcaacagatg ttatttcagt ctcagtgcat ctcctctggc tttctttgac tgaaggtgtt   2760

tataggaagg aagttaaaaa aaaaaaaagc tcattgagat tctttaccaa ttctttacaa   2820

gatttctggg ggtgacaggg aaagcaaaag gacttcaaag caaaagggtg cacaagagct   2880

tacttcaccc tgaaaatcag tattattaat gaaaagtact gttttcttaa agaagtcgaa   2940

tgtcctttag atgaacaaga ccaagtatac atctccatta gattaaaatg tagcacaggg   3000

ttaaaaatta tcagtttaat ctctttaaga acagtattat cagagtttaa aatgagttag   3060

ctctgtttat ctacacacag caaacccatt cgcagcctct tggccacatg tattcagatg   3120

tttgaaatag tgaatcattt cattttcatt ctaaaacaat actgacttag ccatatacct   3180

tctgtttgtc aatctgaaac ttgcttacat ctaataagta gacctcttat aacactgcaa   3240

ccattctaag agttggaatt tatttttgcc aagtattaag tactgttaca tctaaaatac   3300

agaatgtcaa atggttgcat agcttgtttc ccacaacaag gaggaaaaga acaggaatac   3360

aaactctgta atatgctgat aaagaagcct tagaactgcc aactggcttg atggttcaat   3420

tagtaagcta atttctccca cacccgctcc ttgattttta gactaatttt cccaaagcaa   3480

ggtttagtca cacaaacttg aaagtacatt taaaatgttc ttagttgtca tcctactttt   3540

attgcctatg gaatatgcta atttctaaaa aaaatacggg agaggcacca aacccctaaa   3600

ttctagtgca ataatttaaa aaacaaaaaa caaaacaaaa caaaaaacat gttatatgca   3660

cccccctccc aaagctgatt ttaagactgg ctagaattca aaatataaaa aataaaacta   3720

tgaagtgatt tgaaatcggt tttaaaaagt tgttagtgca agagaaattt tatgtttaag   3780

ccatcatggc aatatatgca aagtttaaat gaatgacaga aatcttgatt ttagactgta   3840

tgttgtgctg ttttgagtac actttatttc ggagatattt agtattttct atacactctg   3900

aaatcatgag catttcactt tttctaagtc aattatttca taaggatttt attaatagat   3960

attggtaaat agaactttgg aaatcttaat tcagaattct tactatacct gagtcttttg   4020

taagctatag ttttatgtac aaccttgtac agtttttttg acatacaatt cagaactttg   4080

tttattctct tggactttgt tctggccaat acattttttt taaatcttta agaagaactg   4140

tgattgtttt agtgggtatt tttctaatta aatgaaaact tgtataatgg tattttagag   4200

aatgccagta agtgcatgtt tcaagttaat gtttttctca tcacttgtat gtttctaaca   4260

cagcatggga ctttaataaa accatcctgg aaacttaa                           4298


<210>  7082
<211>  311
<212>  PRT
<213>  Homosapiens

<400>  7082

Met Thr Gly Ser Ala Ala Asp Thr His Arg Cys Pro His Pro Lys Gly 
1               5                   10                  15      


Ala Lys Gly Thr Arg Ser Arg Ser Ser His Ala Arg Pro Val Ser Leu 
            20                  25                  30          


Ala Thr Ser Gly Gly Ser Glu Glu Glu Asp Lys Asp Gly Gly Val Leu 
        35                  40                  45              


Phe His Val Asn Lys Ser Gly Phe Pro Ile Asp Ser His Thr Trp Glu 
    50                  55                  60                  


Arg Met Trp Met His Val Ala Lys Val His Pro Lys Gly Gly Glu Met 
65                  70                  75                  80  


Val Gly Ala Ile Arg Asn Ala Ala Phe Leu Ala Lys Pro Ser Ile Pro 
                85                  90                  95      


Gln Val Pro Asn Tyr Arg Leu Ser Met Thr Ile Pro Asp Trp Leu Gln 
            100                 105                 110         


Ala Ile Gln Asn Tyr Met Lys Thr Leu His Tyr Leu Thr Asn Gly Gln 
        115                 120                 125             


Pro Ser Ile Glu Arg Phe Pro Ile Ser Phe Lys Thr Tyr Phe Ser Gly 
    130                 135                 140                 


Asn Tyr Phe His His Val Val Leu Gly Ile Tyr Cys Asn Gly Arg Tyr 
145                 150                 155                 160 


Gly Ser Leu Gly Met Ser Arg Arg Ala Glu Leu Met Asp Lys Pro Leu 
                165                 170                 175     


Thr Phe Arg Thr Leu Ser Asp Leu Ile Phe Asp Phe Glu Asp Ser Tyr 
            180                 185                 190         


Lys Lys Tyr Leu His Thr Val Lys Lys Val Lys Ile Gly Leu Tyr Val 
        195                 200                 205             


Pro His Glu Pro His Ser Phe Gln Pro Ile Glu Trp Lys Gln Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Lys Met Leu Arg Ala Asp Ile Arg Lys Glu Leu Glu 
225                 230                 235                 240 


Lys Tyr Ala Arg Asp Met Arg Met Lys Ile Leu Lys Pro Ala Ser Ala 
                245                 250                 255     


His Ser Pro Thr Gln Val Arg Ser Arg Gly Lys Ser Leu Ser Pro Arg 
            260                 265                 270         


Arg Arg Gln Ala Ser Pro Pro Arg Arg Leu Gly Arg Arg Glu Lys Ser 
        275                 280                 285             


Pro Ala Leu Pro Glu Lys Lys Val Ala Asp Leu Ser Thr Leu Asn Glu 
    290                 295                 300                 


Val Gly Tyr Gln Ile Arg Ile 
305                 310     


<210>  7083
<211>  4163
<212>  DNA
<213>  Homosapiens

<400>  7083
attcgagaat gggacatgga atgaggcgac ggccccagca agccccagca gccccagccc     60

cagccccagg cccagcagca gcagcagcag cccctgctct cccgccgccc ggagaggctc    120

tgcagccatg aagccaaccg tcccgaggca ccgccggtaa gcagggagcc tccgcggacc    180

cgtgagcctc gccaccagcg ggggctcaga ggaggaggac aaagacggcg gggtgctgtt    240

ccacgtcaac aagagcggct tccccatcga cagccacacc tgggagcgca tgtggatgca    300

cgtggccaag gtgcacccta aggggggaga aatggtgggc gccatcagga acgccgcctt    360

cttggcaaag ccttcaatac cccaggtccc aaactacagg ctgtcgatga cgatcccaga    420

ctggctccag gcgatccaga attacatgaa gaccctacaa tataatcaca cagggaccca    480

gttctttgaa attaggaaaa tgagaccgct gagtgggtta atggaaacag caaaagaaat    540

gacccgagag tccttgccta tcaaatgcct tgaagctgtc atcctgggca tctacttaac    600

caatgggcag ccttccattg agcggttccc catcagcttt aaaacctact tctcaggaaa    660

ctactttcac cacgttgtgc tggggattta ctgcaatggc cgctatggct cattgggcat    720

gagccgcagg gctgagctga tggacaagcc attgactttt cggactctga gtgacctcat    780

ctttgacttt gaggactctt acaagaaata cctgcacaca gtcaagaagg tcaagattgg    840

gctgtacgtc ccccatgagc ctcatagctt ccagcccatt gagtggaagc agctggtcct    900

caacgtctca aagatgctga gggctgacat aaggaaggag ctggagaaat atgccaggga    960

catgagaatg aagatcctga aacctgcaag tgcccactct ccgacccaag tgagaagccg   1020

gggaaaatcc ctgtccccca gaaggagaca ggcaagcccc ccgaggaggc tcggccggcg   1080

agagaagtcg cctgcactgc ctgaaaagaa ggtggctgat ctgagcactc tgaatgaagt   1140

gggctatcaa atccgaattt agccaagcca taccggccag caagagggtt tctgtggtgc   1200

ttctctctgc actttaccca gcatcttcag gaggaactgc aactatttat taagaacttg   1260

tgaattttat ttttaaggat tcacctggaa atagaatctg agtgggtggt aaccattagc   1320

tttaaaaaat tcactaaaag gcaccatgaa aaggctgaag taataagccc cactggggtt   1380

ggactatgtc cctcactcaa gatcttaagg ataaccgtaa ctgaagtttt atatttttcc   1440

atttacctac tttcttttac ttgctttgaa cattatgcct caccaatagt aaatgttcat   1500

gaaataatct cttgaacttt tggtatagta aggtaactct aacagtatta ctgtcttttt   1560

cagcaataac agaaagcaaa aatgggtggg ttttttttaa gcagttatta cctcagcatt   1620

ttgacatcag atatgcaaac ttaatggcgt tttgtttttt tatattctat ttgtattctt   1680

tccccagtat ttcccatggg gatctccaca agtttggagt tttttcctgg tgcacacacg   1740

tgaggagatt taaggtacta tatgcaagtg ttttactaaa aagcactgaa attcttctgg   1800

caatacaaga accattttca ggatcttgga gttacttcct tcttaatctt tcttaaagca   1860

ttcactgatg tttttgtttt ttcaaaatga aacaaaaata tcacattgag aagctagtct   1920

atgttctgtc actaacattt aaactttgca gactctaaca aaaagcacaa gaggtcacgt   1980

actattatac aaatttagcg gtactggatt tacctctgac attaacacac tcaggcagag   2040

accaggagtg atcagcaggt cttcagaacc aaaaaacctt tctgttcaca tttcatctga   2100

tttttaaact gaggcaggct ttgattcttc tgaaggatgc caagaatcaa actaagggag   2160

gactcactgt taaagatgtg ttctgatgtc ttatattaag accaaatgtg acatgatgtg   2220

attatcttcc agtactttgc ttttaggtac catttcatga cattttagga atgagtattg   2280

gaaaatataa agaattagaa aagcagcact ttttttttaa tggaaaagtc ttcggtccag   2340

tgttacacct tatagtgtaa ttcagtccct aagcacagaa tgaatgtctg gcctgcatat   2400

ggtagttaca gtgtaacctc tggctgcaga ccacacagga caaccctaac agcctagtct   2460

tgtatggtgt aaatatcaag agtacagctt caatttcatt tgctttatct tagcaacaat   2520

gccaactcag gagagcagac ggccgatttc agtgaagtct ggtagtcaac agatgttatt   2580

tcagtctcag tgcatctcct ctggctttct ttgactgaag gtgtttatag gaaggaagtt   2640

aaaaaaaaaa aaagctcatt gagattcttt accaattctt tacaagattt ctgggggtga   2700

cagggaaagc aaaaggactt caaagcaaaa gggtgcacaa gagcttactt caccctgaaa   2760

atcagtatta ttaatgaaaa gtactgtttt cttaaagaag tcgaatgtcc tttagatgaa   2820

caagaccaag tatacatctc cattagatta aaatgtagca cagggttaaa aattatcagt   2880

ttaatctctt taagaacagt attatcagag tttaaaatga gttagctctg tttatctaca   2940

cacagcaaac ccattcgcag cctcttggcc acatgtattc agatgtttga aatagtgaat   3000

catttcattt tcattctaaa acaatactga cttagccata taccttctgt ttgtcaatct   3060

gaaacttgct tacatctaat aagtagacct cttataacac tgcaaccatt ctaagagttg   3120

gaatttattt ttgccaagta ttaagtactg ttacatctaa aatacagaat gtcaaatggt   3180

tgcatagctt gtttcccaca acaaggagga aaagaacagg aatacaaact ctgtaatatg   3240

ctgataaaga agccttagaa ctgccaactg gcttgatggt tcaattagta agctaatttc   3300

tcccacaccc gctccttgat ttttagacta attttcccaa agcaaggttt agtcacacaa   3360

acttgaaagt acatttaaaa tgttcttagt tgtcatccta cttttattgc ctatggaata   3420

tgctaatttc taaaaaaaat acgggagagg caccaaaccc ctaaattcta gtgcaataat   3480

ttaaaaaaca aaaaacaaaa caaaacaaaa aacatgttat atgcaccccc ctcccaaagc   3540

tgattttaag actggctaga attcaaaata taaaaaataa aactatgaag tgatttgaaa   3600

tcggttttaa aaagttgtta gtgcaagaga aattttatgt ttaagccatc atggcaatat   3660

atgcaaagtt taaatgaatg acagaaatct tgattttaga ctgtatgttg tgctgttttg   3720

agtacacttt atttcggaga tatttagtat tttctataca ctctgaaatc atgagcattt   3780

cactttttct aagtcaatta tttcataagg attttattaa tagatattgg taaatagaac   3840

tttggaaatc ttaattcaga attcttacta tacctgagtc ttttgtaagc tatagtttta   3900

tgtacaacct tgtacagttt ttttgacata caattcagaa ctttgtttat tctcttggac   3960

tttgttctgg ccaatacatt ttttttaaat ctttaagaag aactgtgatt gttttagtgg   4020

gtatttttct aattaaatga aaacttgtat aatggtattt tagagaatgc cagtaagtgc   4080

atgtttcaag ttaatgtttt tctcatcact tgtatgtttc taacacagca tgggacttta   4140

ataaaaccat cctggaaact taa                                           4163


<210>  7084
<211>  290
<212>  PRT
<213>  Homosapiens

<400>  7084

Met Trp Met His Val Ala Lys Val His Pro Lys Gly Gly Glu Met Val 
1               5                   10                  15      


Gly Ala Ile Arg Asn Ala Ala Phe Leu Ala Lys Pro Ser Ile Pro Gln 
            20                  25                  30          


Val Pro Asn Tyr Arg Leu Ser Met Thr Ile Pro Asp Trp Leu Gln Ala 
        35                  40                  45              


Ile Gln Asn Tyr Met Lys Thr Leu Gln Tyr Asn His Thr Gly Thr Gln 
    50                  55                  60                  


Phe Phe Glu Ile Arg Lys Met Arg Pro Leu Ser Gly Leu Met Glu Thr 
65                  70                  75                  80  


Ala Lys Glu Met Thr Arg Glu Ser Leu Pro Ile Lys Cys Leu Glu Ala 
                85                  90                  95      


Val Ile Leu Gly Ile Tyr Leu Thr Asn Gly Gln Pro Ser Ile Glu Arg 
            100                 105                 110         


Phe Pro Ile Ser Phe Lys Thr Tyr Phe Ser Gly Asn Tyr Phe His His 
        115                 120                 125             


Val Val Leu Gly Ile Tyr Cys Asn Gly Arg Tyr Gly Ser Leu Gly Met 
    130                 135                 140                 


Ser Arg Arg Ala Glu Leu Met Asp Lys Pro Leu Thr Phe Arg Thr Leu 
145                 150                 155                 160 


Ser Asp Leu Ile Phe Asp Phe Glu Asp Ser Tyr Lys Lys Tyr Leu His 
                165                 170                 175     


Thr Val Lys Lys Val Lys Ile Gly Leu Tyr Val Pro His Glu Pro His 
            180                 185                 190         


Ser Phe Gln Pro Ile Glu Trp Lys Gln Leu Val Leu Asn Val Ser Lys 
        195                 200                 205             


Met Leu Arg Ala Asp Ile Arg Lys Glu Leu Glu Lys Tyr Ala Arg Asp 
    210                 215                 220                 


Met Arg Met Lys Ile Leu Lys Pro Ala Ser Ala His Ser Pro Thr Gln 
225                 230                 235                 240 


Val Arg Ser Arg Gly Lys Ser Leu Ser Pro Arg Arg Arg Gln Ala Ser 
                245                 250                 255     


Pro Pro Arg Arg Leu Gly Arg Arg Glu Lys Ser Pro Ala Leu Pro Glu 
            260                 265                 270         


Lys Lys Val Ala Asp Leu Ser Thr Leu Asn Glu Val Gly Tyr Gln Ile 
        275                 280                 285             


Arg Ile 
    290 


<210>  7085
<211>  4224
<212>  DNA
<213>  Homosapiens

<400>  7085
attcgagaat gggacatgga atgaggcgac ggccccagca agccccagca gccccagccc     60

cagccccagg cccagcagca gcagcagcag cccctgctct cccgccgccc ggagaggctc    120

tgcagccatg aagccaaccg tcccgaggca ccgccggtaa gcagggagcc tccgcggagc    180

tcccgccgcc gctccccctt ggcgccaaag gcacccggtc ccggagcagc cacgcgcggc    240

ccgtgagcct cgccaccagc gggggctcag aggaggagga caaagacggc ggggtgctgt    300

tccacgtcaa caagagcggc ttccccatcg acagccacac ctgggagcgc atgtggatgc    360

acgtggccaa ggtgcaccct aaggggggag aaatggtggg cgccatcagg aacgccgcct    420

tcttggcaaa gccttcaata ccccaggtcc caaactacag gctgtcgatg acgatcccag    480

actggctcca ggcgatccag aattacatga agaccctaca atataatcac acagggaccc    540

agttctttga aattaggaaa atgagaccgc tgagtgggtt aatggaaaca gcaaaagaaa    600

tgacccgaga gtccttgcct atcaaatgcc ttgaagctgt catcctgggc atctacttaa    660

ccaatgggca gccttccatt gagcggttcc ccatcagctt taaaacctac ttctcaggaa    720

actactttca ccacgttgtg ctggggattt actgcaatgg ccgctatggc tcattgggca    780

tgagccgcag ggctgagctg atggacaagc cattgacttt tcggactctg agtgacctca    840

tctttgactt tgaggactct tacaagaaat acctgcacac agtcaagaag gtcaagattg    900

ggctgtacgt cccccatgag cctcatagct tccagcccat tgagtggaag cagctggtcc    960

tcaacgtctc aaagatgctg agggctgaca taaggaagga gctggagaaa tatgccaggg   1020

acatgagaat gaagatcctg aaacctgcaa gtgcccactc tccgacccaa gtgagaagcc   1080

ggggaaaatc cctgtccccc agaaggagac aggcaagccc cccgaggagg ctcggccggc   1140

gagagaagtc gcctgcactg cctgaaaaga aggtggctga tctgagcact ctgaatgaag   1200

tgggctatca aatccgaatt tagccaagcc ataccggcca gcaagagggt ttctgtggtg   1260

cttctctctg cactttaccc agcatcttca ggaggaactg caactattta ttaagaactt   1320

gtgaatttta tttttaagga ttcacctgga aatagaatct gagtgggtgg taaccattag   1380

ctttaaaaaa ttcactaaaa ggcaccatga aaaggctgaa gtaataagcc ccactggggt   1440

tggactatgt ccctcactca agatcttaag gataaccgta actgaagttt tatatttttc   1500

catttaccta ctttctttta cttgctttga acattatgcc tcaccaatag taaatgttca   1560

tgaaataatc tcttgaactt ttggtatagt aaggtaactc taacagtatt actgtctttt   1620

tcagcaataa cagaaagcaa aaatgggtgg gtttttttta agcagttatt acctcagcat   1680

tttgacatca gatatgcaaa cttaatggcg ttttgttttt ttatattcta tttgtattct   1740

ttccccagta tttcccatgg ggatctccac aagtttggag ttttttcctg gtgcacacac   1800

gtgaggagat ttaaggtact atatgcaagt gttttactaa aaagcactga aattcttctg   1860

gcaatacaag aaccattttc aggatcttgg agttacttcc ttcttaatct ttcttaaagc   1920

attcactgat gtttttgttt tttcaaaatg aaacaaaaat atcacattga gaagctagtc   1980

tatgttctgt cactaacatt taaactttgc agactctaac aaaaagcaca agaggtcacg   2040

tactattata caaatttagc ggtactggat ttacctctga cattaacaca ctcaggcaga   2100

gaccaggagt gatcagcagg tcttcagaac caaaaaacct ttctgttcac atttcatctg   2160

atttttaaac tgaggcaggc tttgattctt ctgaaggatg ccaagaatca aactaaggga   2220

ggactcactg ttaaagatgt gttctgatgt cttatattaa gaccaaatgt gacatgatgt   2280

gattatcttc cagtactttg cttttaggta ccatttcatg acattttagg aatgagtatt   2340

ggaaaatata aagaattaga aaagcagcac ttttttttta atggaaaagt cttcggtcca   2400

gtgttacacc ttatagtgta attcagtccc taagcacaga atgaatgtct ggcctgcata   2460

tggtagttac agtgtaacct ctggctgcag accacacagg acaaccctaa cagcctagtc   2520

ttgtatggtg taaatatcaa gagtacagct tcaatttcat ttgctttatc ttagcaacaa   2580

tgccaactca ggagagcaga cggccgattt cagtgaagtc tggtagtcaa cagatgttat   2640

ttcagtctca gtgcatctcc tctggctttc tttgactgaa ggtgtttata ggaaggaagt   2700

taaaaaaaaa aaaagctcat tgagattctt taccaattct ttacaagatt tctgggggtg   2760

acagggaaag caaaaggact tcaaagcaaa agggtgcaca agagcttact tcaccctgaa   2820

aatcagtatt attaatgaaa agtactgttt tcttaaagaa gtcgaatgtc ctttagatga   2880

acaagaccaa gtatacatct ccattagatt aaaatgtagc acagggttaa aaattatcag   2940

tttaatctct ttaagaacag tattatcaga gtttaaaatg agttagctct gtttatctac   3000

acacagcaaa cccattcgca gcctcttggc cacatgtatt cagatgtttg aaatagtgaa   3060

tcatttcatt ttcattctaa aacaatactg acttagccat ataccttctg tttgtcaatc   3120

tgaaacttgc ttacatctaa taagtagacc tcttataaca ctgcaaccat tctaagagtt   3180

ggaatttatt tttgccaagt attaagtact gttacatcta aaatacagaa tgtcaaatgg   3240

ttgcatagct tgtttcccac aacaaggagg aaaagaacag gaatacaaac tctgtaatat   3300

gctgataaag aagccttaga actgccaact ggcttgatgg ttcaattagt aagctaattt   3360

ctcccacacc cgctccttga tttttagact aattttccca aagcaaggtt tagtcacaca   3420

aacttgaaag tacatttaaa atgttcttag ttgtcatcct acttttattg cctatggaat   3480

atgctaattt ctaaaaaaaa tacgggagag gcaccaaacc cctaaattct agtgcaataa   3540

tttaaaaaac aaaaaacaaa acaaaacaaa aaacatgtta tatgcacccc cctcccaaag   3600

ctgattttaa gactggctag aattcaaaat ataaaaaata aaactatgaa gtgatttgaa   3660

atcggtttta aaaagttgtt agtgcaagag aaattttatg tttaagccat catggcaata   3720

tatgcaaagt ttaaatgaat gacagaaatc ttgattttag actgtatgtt gtgctgtttt   3780

gagtacactt tatttcggag atatttagta ttttctatac actctgaaat catgagcatt   3840

tcactttttc taagtcaatt atttcataag gattttatta atagatattg gtaaatagaa   3900

ctttggaaat cttaattcag aattcttact atacctgagt cttttgtaag ctatagtttt   3960

atgtacaacc ttgtacagtt tttttgacat acaattcaga actttgttta ttctcttgga   4020

ctttgttctg gccaatacat tttttttaaa tctttaagaa gaactgtgat tgttttagtg   4080

ggtatttttc taattaaatg aaaacttgta taatggtatt ttagagaatg ccagtaagtg   4140

catgtttcaa gttaatgttt ttctcatcac ttgtatgttt ctaacacagc atgggacttt   4200

aataaaacca tcctggaaac ttaa                                          4224


<210>  7086
<211>  290
<212>  PRT
<213>  Homosapiens

<400>  7086

Met Trp Met His Val Ala Lys Val His Pro Lys Gly Gly Glu Met Val 
1               5                   10                  15      


Gly Ala Ile Arg Asn Ala Ala Phe Leu Ala Lys Pro Ser Ile Pro Gln 
            20                  25                  30          


Val Pro Asn Tyr Arg Leu Ser Met Thr Ile Pro Asp Trp Leu Gln Ala 
        35                  40                  45              


Ile Gln Asn Tyr Met Lys Thr Leu Gln Tyr Asn His Thr Gly Thr Gln 
    50                  55                  60                  


Phe Phe Glu Ile Arg Lys Met Arg Pro Leu Ser Gly Leu Met Glu Thr 
65                  70                  75                  80  


Ala Lys Glu Met Thr Arg Glu Ser Leu Pro Ile Lys Cys Leu Glu Ala 
                85                  90                  95      


Val Ile Leu Gly Ile Tyr Leu Thr Asn Gly Gln Pro Ser Ile Glu Arg 
            100                 105                 110         


Phe Pro Ile Ser Phe Lys Thr Tyr Phe Ser Gly Asn Tyr Phe His His 
        115                 120                 125             


Val Val Leu Gly Ile Tyr Cys Asn Gly Arg Tyr Gly Ser Leu Gly Met 
    130                 135                 140                 


Ser Arg Arg Ala Glu Leu Met Asp Lys Pro Leu Thr Phe Arg Thr Leu 
145                 150                 155                 160 


Ser Asp Leu Ile Phe Asp Phe Glu Asp Ser Tyr Lys Lys Tyr Leu His 
                165                 170                 175     


Thr Val Lys Lys Val Lys Ile Gly Leu Tyr Val Pro His Glu Pro His 
            180                 185                 190         


Ser Phe Gln Pro Ile Glu Trp Lys Gln Leu Val Leu Asn Val Ser Lys 
        195                 200                 205             


Met Leu Arg Ala Asp Ile Arg Lys Glu Leu Glu Lys Tyr Ala Arg Asp 
    210                 215                 220                 


Met Arg Met Lys Ile Leu Lys Pro Ala Ser Ala His Ser Pro Thr Gln 
225                 230                 235                 240 


Val Arg Ser Arg Gly Lys Ser Leu Ser Pro Arg Arg Arg Gln Ala Ser 
                245                 250                 255     


Pro Pro Arg Arg Leu Gly Arg Arg Glu Lys Ser Pro Ala Leu Pro Glu 
            260                 265                 270         


Lys Lys Val Ala Asp Leu Ser Thr Leu Asn Glu Val Gly Tyr Gln Ile 
        275                 280                 285             


Arg Ile 
    290 


<210>  7087
<211>  1731
<212>  DNA
<213>  Homosapiens

<400>  7087
agcagcccca gccccagccc caggcccagc agcagcagca gcagcccctg ctctcccgcc     60

gcccggagag gctctgcagc catgaagcca accgtcccga gccttcaata ccccaggtcc    120

caaactacag gctgtcgatg acgatcccag actggctcca ggcgatccag aattacatga    180

agaccctaca gtatccttcc aaccaaggtc tgagcacacc cagccagggg acaggcatgg    240

tgatcgcaag cctggtggca aatctgtccc cagctggtca tcaaaagctc tctaaggtta    300

atggaaacag caaaagaaat gacccgagag tccttgccta tcaaatgcct tgaagctgtc    360

atcctgggca tctacttaac caatgggcag ccttccattg agcggttccc catcagcttt    420

aaaacctact tctcaggaaa ctactttcac cacgttgtgc tggggattta ctgcaatggc    480

cgctatggct cattgggcat gagccgcagg gctgagctga tggacaagcc attgactttt    540

cggactctga gtgacctcat ctttgacttt gaggactctt acaagaaata cctgcacaca    600

gtcaagaagg tcaagattgg gctgtacgtc ccccatgagc ctcatagctt ccagcccatt    660

gagtggaagc agctggtcct caacgtctca aagatgctga gggctgacat aaggaaggag    720

ctggagaaat atgccaggga catgagaatg aagggcttgt gcagtcacta agagaaaagg    780

attatgctga cttcaggcct ggctatgttt agcacttgtg gacttgtcat cttcactctg    840

caggacctgg agtggagatt cctgatcaat taaaaccatt ctgtcatatg tgtgggatgg    900

gagcatcaga ggaagaacag gctggtttct gaggcaatag agatgggact ttgccttcgt    960

gaggagagga acttgccaag caaacaaaca cagccccggg gagactgagg cattgggctg   1020

tgttcctctc tctacacggc acagggagca caatgtgacc atctgtatat ctgtcttgga   1080

agtggtgccc ttgctgcttg acagtacagg acgagagagg aatgtgtgtg tctccagcct   1140

ccttttttag aagtcttcct gctcaatgcc ttctaaacca tggcatcatg attgggctgg   1200

ggggtggaat gtggtgctag aagaagacct gagggtggag gtcccttagg aaccagggtg   1260

attaactcct cacatctcct tcagatcctg aaacctgcaa gtgcccactc tccgacccaa   1320

gtgagaagcc ggggaaaatc cctgtccccc agaaggagac aggcaagccc cccgaggagg   1380

ctcggccggc gagagaagtc ccctgaggcc agtgatccca catctacttc ttagaccaaa   1440

ataacccact taagcaatga cagattggag atgctgggga tgcccaaatt caccagcgat   1500

aatccgctgg caaatatttg aactatagcc atcctgggaa aaaatactgc ttttcttaat   1560

aatagcagca tgctgtgtca cccagcctct tgccatgctg gaaccatgtg gcacagtgca   1620

cagggggctt ggttgaatcc caactgtgcc acgtgttagc tgtgcagctg ggcacatcct   1680

tcctcctcgg ggagccttgg tttcttcatc cataaaagag tatcaaatgc t            1731


<210>  7088
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  7088

Met Glu Thr Ala Lys Glu Met Thr Arg Glu Ser Leu Pro Ile Lys Cys 
1               5                   10                  15      


Leu Glu Ala Val Ile Leu Gly Ile Tyr Leu Thr Asn Gly Gln Pro Ser 
            20                  25                  30          


Ile Glu Arg Phe Pro Ile Ser Phe Lys Thr Tyr Phe Ser Gly Asn Tyr 
        35                  40                  45              


Phe His His Val Val Leu Gly Ile Tyr Cys Asn Gly Arg Tyr Gly Ser 
    50                  55                  60                  


Leu Gly Met Ser Arg Arg Ala Glu Leu Met Asp Lys Pro Leu Thr Phe 
65                  70                  75                  80  


Arg Thr Leu Ser Asp Leu Ile Phe Asp Phe Glu Asp Ser Tyr Lys Lys 
                85                  90                  95      


Tyr Leu His Thr Val Lys Lys Val Lys Ile Gly Leu Tyr Val Pro His 
            100                 105                 110         


Glu Pro His Ser Phe Gln Pro Ile Glu Trp Lys Gln Leu Val Leu Asn 
        115                 120                 125             


Val Ser Lys Met Leu Arg Ala Asp Ile Arg Lys Glu Leu Glu Lys Tyr 
    130                 135                 140                 


Ala Arg Asp Met Arg Met Lys Gly Leu Cys Ser His 
145                 150                 155     


<210>  7089
<211>  5402
<212>  DNA
<213>  Homosapiens

<400>  7089
aagtgttggg attacaggca tgagccaccg cacctggcca acaattttta atgtggatga     60

aaccacttta tattgcaaga agatgccatc taggacttca taactagaaa gaagaagtca    120

gtgcctggtt tcaaaggaca ggctgactct tttgttagga gctaatatag cttgttactt    180

taagttaaag tcagcattca ttgaccattc tgaaaatcct agggcactta aaaattatgc    240

taaatccact ctacctgtgc tatgtcagtg gaaaaacaaa gcttggggat gacagtgcat    300

ctgtttatgg catagaatat tttaagcaca ctgctgagac cactattcag aaaaacagat    360

tcctttccaa agattactgt tcgttcacaa ggcacctggt cacccaagag ctctgatgaa    420

gatgtacaag gaaatgaatg ttttttcatc cctgctaaca cggcatccat tctgcagcct    480

atggaatcaa ggagtaattt tgtacctaca ggtctcctta tttaagaaat acatttcata    540

ggctatagct gccatagaag tgatttctct gatggatctg gggaaagtaa attgcaaacc    600

tgcaaaggat tcagcatcct aaatgctatt cagaacattc gtgattcatg ggaggaggtc    660

aaaatatcac cattaaaaag agtttggtag aagttgattc cagccctcat ggatgacttt    720

gaggggttca agacttcagg ggaggaagta actgtagatg tggtggaaat agcaagagaa    780

ctagaagtgg agcctgaaga attaactgaa ttgtttcaat ctcatgataa aacttaaata    840

gatgaggagt tgcttcttat agatgagcag agtattttct tgagatgcat tctattcctg    900

gtgaagatgc tgtgaacatt gctgaaatta caacaaagga ttttaaatgt tacataaatt    960

taattgataa aacattggaa gggtttccaa ttttgaaaaa aagttccgtg gataaagtgc   1020

tgtcaaatag catcagatgc tacagaaaaa tcttttatga aaggaagcat caatggctgc   1080

agcaaatttc attgttgtct tattttaaga aattgccaca gccaaccccc actttaagca   1140

accatcaccc tgatcagcca gcagtcatta atatctaggc aagatcctcc acctgtaaaa   1200

agatgatgac tcactgaagg ctgagatgat tgttaggata ttttaacaat gaagtatttt   1260

taaattaagg tatgtatttt cttaggcata atgctattgc acacttagta aactacagta   1320

tagtataaac gcaacttaca tgcactggga aactgaaaaa attatgtgac ttgctttatt   1380

gagatactca ctttattgtg gtggcctgaa accaaacccg cagtacctgt gagcatgcct   1440

atatttgata caataggaac tatattgcag gtagtaaaaa atgatgaata gtgttagttc   1500

aaagcgatag atgatttgta tgtccaaatt aaagaaaagc atgtatggga aaaagattgt   1560

catttttatg taaatgataa gtgctttctg aattgtattt aaagaaaaga agattttata   1620

agtccaaaga atcacttaat acaatgaata aagggtaata atttaccact tttggattac   1680

cttttattta agacataaat ttttcaactc ataagctatt taaaatcttt tcacttaaga   1740

tacctgttga aattttgttt aggtatctgg ccaggaacag tcttcacggg gacaaagaat   1800

tttatctatt ccaatttggc ccccaaacct aggtatctca cagaactgtg tgtatgaggt   1860

acagcaggta ccaaaagtag aaaagacaga cagtgatctg acacaaacac agctgaagca   1920

aacagaggtc ctagtgacag ctgaaaaatt gtcttcaaat ttacagcacc atttcagttt   1980

gtcatctgtt tattcacatt actttcctga cactggaatt ccagaagtga ccacctgtca   2040

ttcccgaagt gccataactg tggattatat tttctactct gcagaaaagg aagatgttgc   2100

tgggcaccca ggagctgaag ttgctttggt tggtggcttg aaacttctag ctagactgtc   2160

acttcttaca gaacaagact tatggactgt taatggactt ccaaacgaaa ataactcttc   2220

agatcatctg cctttattgg caaagttcag acttgagctc tgactctctt tgatcacata   2280

ctaattttct ttccaatttg tattgttttt caaagaatgt aaagttctta agtgtatgca   2340

tgttgtttat ttttgcactg tggagattct gaagcggtta tgttagatgc tttgaaactc   2400

catatcagaa gaaataactt tataacaatt ttttttaata atgaaaaata ttttcgtgac   2460

aagtgagctc taaattctct ttattgtaaa agagatgtaa aggttttata ttctaaatcc   2520

tagtaaaatt gacagtgatt tttaaatata atgcatcttc ctttgtctgc ttagtaaaaa   2580

atttcatttc ataattttgg caagctctgt agtggatcca aagtatcttt gagttcttgc   2640

aaactacaag ttgtttcctt tccagaaggc ttgatttcat taggagaccc ctctattgag   2700

ttctaaatag tttatcttag aaagccttgg gtcattcaca ggtatccaac cagccattgt   2760

ttagtttgtt tttgaagggg tttgataatg ctttttaagt tgtacagaat gcttaatcca   2820

tcttattact gtcctgagcc atgtaatatg cctgcatcgt gttggggaaa tgtttgggaa   2880

atataagcca gcataacgtg taaagctcac tctttcaccc tggaacagac aagaggtggg   2940

cttaatagag gcagagactg gggatatacc tttgtttccc tagcattttt atttatttat   3000

ttttatttta ttttattttt tgagatggag tttcactctt gttgcccagg ctgggggtgc   3060

aatggcgcaa tctttgctca ctgcaacccc tgcctcccgg gctcaagcga ttctcctgcc   3120

tcagcctctc gagtagctgg gattacaggc atgcgtcacc actcccagct aattttgtat   3180

tttcagtaga gacagggttt ccccatgttg gttaggctgg tctcgaactc ccaacctcag   3240

gtgatccgcc cacctcagct ctcaaagtgc tgggattaca ggcgggagcc actgcacatg   3300

gcagcatttt ttaaaaattc agttttaaga tctctggttt aggggagaga ttttatttta   3360

ctgaaccagt tctatagaaa tttattttat taggaaattt gtctttggaa caaagtggca   3420

gctataaaat tatttttgtt aagcctcaga aatatgagga agcctgtaaa actctagtgg   3480

ggagatatta acttggagac ctaatgctct gtaaatagtc atttaaactg ttggttttag   3540

tggttttgtt tctaaaatgt tttcttttac cgtgatgcac cagtatgaga tggtgctgac   3600

actttctatg aagtggttat gagcaggttt aataaatcct ctatacaagt gtttgaatca   3660

attttaaaac ataaaaagtg gaaatttcct tttttgtaga cagtaggaac aaggaattat   3720

atgcattttt actaagtagt aattttacac tgaattgtaa atgtttttac agtgagtttt   3780

attaatagaa tgcttcacct taaattggaa aacaataata gtcttggact aagtctttgt   3840

actaaagcat ttgctataat tatttttaaa aaaacaaaca gatgaaaacc tcagagaagg   3900

catgtggatt ataagatttg tctagtaaaa attgtaattg aatatgttta aatatttaat   3960

ttctcatttt ggggggtttt tattttttta ttttttagat ggtgtctcac gctatcgccc   4020

aggctggagt gcagtggcgc gaactcggct cactgcaacc tccgcctcct gggttcaagc   4080

aattctcctt cctcagcctc ccaagtagct gggattacag gcatgcacca ccatgcccag   4140

ctaatttttg tatttttagt agagatggaa ttttgccatg ttggccaggc tggtcttgaa   4200

ctcctgacct caggggtgat ccacccgcct cgggctccca aagtgctgtg attacaggca   4260

tgagccacca tgcctggcct ttggggggat tttaattaca gtattaatta tagttctagg   4320

atttcccaca ttttatagta gtagtttgca ggatattatg tgccctaatt agcagatata   4380

gacattatca aattataatg atagtataat tatccctttt taatattggg gaaagaaaaa   4440

tgaaaattca ttagttaatt actgctttgt gttgtgtgaa tttattaaca aataacatta   4500

ttacatatag gtcattgtta acaaacaaac atccctgaaa acctctgtga aaatttaatt   4560

ttttatatcc tgattaatat attgtgactt taggcccatt tttcatgtgc ttcactttga   4620

tagagttaat ccataaaatt gctctttact ttagcttatc aaatgaagta ttattttgtg   4680

gactggaggc caaaaagtca atgtgagctt ctcacaggtt tttaaagctc cactaaaaat   4740

aattatccac ttgtctttac ttttgttgac cagaatagtt ggtaactctg ccagagcctg   4800

tacttacctg ccaaaaacaa ttaaatctgg ttaatgcctg aaaccaaatc tctcagtctc   4860

aagtgttata ctatccaagt tttaaatgga aaggtaaact gtggagtaat gaaattttgg   4920

ttttactgta ccttttgcta tcaagataat attcatgttt gaaatcttgt ctttatttgg   4980

aatttagtta ctgtctgctt ttaacctttg ctttcctaaa gaaagtttga gatccagaga   5040

gttcaaggga ttggggaaag agaggcgtca agtcatttgc actttgtacc tgtaagttag   5100

gtaataaact attatactcg tacttctgtg cctgaaggtt ttgtggtagg tatactgaga   5160

tgtataagct gtactgttgc ctttactaaa ctatttcatt gccctttgca gccattttta   5220

cttaggggtg atgctaaaag atgagtgaat tgagatatgt caaaatagag tgatagagtg   5280

tttttaatat agagtctgca gattgtgaaa gaagggtgaa agaacgataa ataggttcag   5340

tagaataaat atataataag aggaccaaaa aaaaaaatca caccatctta cttttttttt   5400

tt                                                                  5402


<210>  7090
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  7090

Met His Ser Ile Pro Gly Glu Asp Ala Val Asn Ile Ala Glu Ile Thr 
1               5                   10                  15      


Thr Lys Asp Phe Lys Cys Tyr Ile Asn Leu Ile Asp Lys Thr Leu Glu 
            20                  25                  30          


Gly Phe Pro Ile Leu Lys Lys Ser Ser Val Asp Lys Val Leu Ser Asn 
        35                  40                  45              


Ser Ile Arg Cys Tyr Arg Lys Ile Phe Tyr Glu Arg Lys His Gln Trp 
    50                  55                  60                  


Leu Gln Gln Ile Ser Leu Leu Ser Tyr Phe Lys Lys Leu Pro Gln Pro 
65                  70                  75                  80  


Thr Pro Thr Leu Ser Asn His His Pro Asp Gln Pro Ala Val Ile Asn 
                85                  90                  95      


Ile 
    


<210>  7091
<211>  4603
<212>  DNA
<213>  Homosapiens

<400>  7091
cggcgagact gcacctccca gcatgccttg cagccaggac tggagtcggt acttaagagt     60

gatggggttc cctagatact ttaggccgtc gcatcgatta tagagattga ggtggaaccc    120

ggggcctggg aactggacgc acgcggaggg cgaagatgga agcctggcgc tgtgtgagga    180

agggctacgg ccactgtgtg gtgggaagag gccggtgtga taaagcggaa ttgggaatat    240

atatgtagcc atgataaaga aaaaacgaag atcctaggag acaaaaatgt tgatcccaaa    300

tgtgaagaca gtgagaacaa gtttgacttt tcagtgatgt cctataatat actttcacaa    360

gatttactgg aagataactc tcacctttat agacattgcc ggcggccagt attacactgg    420

agttttaggt ttcccaatat tctgaaagaa attaaacatt ttgatgcaga cgtactttgt    480

ttgcaagaag ttcaagaaga tcattatgga gcagagatca ggccaagttt ggaatcactg    540

ggttatcact gtgaatataa gatgcggaca ggaaggaaac ctgatggctg tgctatttgc    600

ttcaaacatt ccaaattttc actcttgtca gtgaacccag tggaattctt ccgccctgat    660

atttctctgt tggacagaga caatgttgga ttagttttac tcttacagcc caaaattcca    720

tatgctgcct gccctgcaat ctgcgtagca aatacgcatc tgttgtataa tccaaggcga    780

ggtgatatta agctgacgca attggcaatg ctactggcag agatttccag tgttgcccac    840

cagaaagatg gcagcttctg ccctattgtt atgtgtggtg actttaattc tgttcctggt    900

tctccactat atagtttcat aaaggaagga aaattgaatt atgaaggact tcccatagga    960

aaggtatctg gccaggaaca gtcttcacgg ggacaaagaa ttttatctat tccaatttgg   1020

cccccaaacc taggtatctc acagaactgt gtgtatgagg tacagcaggt accaaaagta   1080

gaaaagacag acagtgatct gacacaaaca cagctgaagc aaacagaggt cctagtgaca   1140

gctgaaaaat tgtcttcaaa tttacagcac catttcagtt tgtcatctgt ttattcacat   1200

tactttcctg acactggaat tccagaagtg accacctgtc attcccgaag tgccataact   1260

gtggattata ttttctactc tgcagaaaag gaagatgttg ctgggcaccc aggagctgaa   1320

gttgctttgg ttggtggctt gaaacttcta gctagactgt cacttcttac agaacaagac   1380

ttatggactg ttaatggact tccaaacgaa aataactctt cagatcatct gcctttattg   1440

gcaaagttca gacttgagct ctgactctct ttgatcacat actaattttc tttccaattt   1500

gtattgtttt tcaaagaatg taaagttctt aagtgtatgc atgttgttta tttttgcact   1560

gtggagattc tgaagcggtt atgttagatg ctttgaaact ccatatcaga agaaataact   1620

ttataacaat tttttttaat aatgaaaaat attttcgtga caagtgagct ctaaattctc   1680

tttattgtaa aagagatgta aaggttttat attctaaatc ctagtaaaat tgacagtgat   1740

ttttaaatat aatgcatctt cctttgtctg cttagtaaaa aatttcattt cataattttg   1800

gcaagctctg tagtggatcc aaagtatctt tgagttcttg caaactacaa gttgtttcct   1860

ttccagaagg cttgatttca ttaggagacc cctctattga gttctaaata gtttatctta   1920

gaaagccttg ggtcattcac aggtatccaa ccagccattg tttagtttgt ttttgaaggg   1980

gtttgataat gctttttaag ttgtacagaa tgcttaatcc atcttattac tgtcctgagc   2040

catgtaatat gcctgcatcg tgttggggaa atgtttggga aatataagcc agcataacgt   2100

gtaaagctca ctctttcacc ctggaacaga caagaggtgg gcttaataga ggcagagact   2160

ggggatatac ctttgtttcc ctagcatttt tatttattta tttttatttt attttatttt   2220

ttgagatgga gtttcactct tgttgcccag gctgggggtg caatggcgca atctttgctc   2280

actgcaaccc ctgcctcccg ggctcaagcg attctcctgc ctcagcctct cgagtagctg   2340

ggattacagg catgcgtcac cactcccagc taattttgta ttttcagtag agacagggtt   2400

tccccatgtt ggttaggctg gtctcgaact cccaacctca ggtgatccgc ccacctcagc   2460

tctcaaagtg ctgggattac aggcgggagc cactgcacat ggcagcattt tttaaaaatt   2520

cagttttaag atctctggtt taggggagag attttatttt actgaaccag ttctatagaa   2580

atttatttta ttaggaaatt tgtctttgga acaaagtggc agctataaaa ttatttttgt   2640

taagcctcag aaatatgagg aagcctgtaa aactctagtg gggagatatt aacttggaga   2700

cctaatgctc tgtaaatagt catttaaact gttggtttta gtggttttgt ttctaaaatg   2760

ttttctttta ccgtgatgca ccagtatgag atggtgctga cactttctat gaagtggtta   2820

tgagcaggtt taataaatcc tctatacaag tgtttgaatc aattttaaaa cataaaaagt   2880

ggaaatttcc ttttttgtag acagtaggaa caaggaatta tatgcatttt tactaagtag   2940

taattttaca ctgaattgta aatgttttta cagtgagttt tattaataga atgcttcacc   3000

ttaaattgga aaacaataat agtcttggac taagtctttg tactaaagca tttgctataa   3060

ttatttttaa aaaaacaaac agatgaaaac ctcagagaag gcatgtggat tataagattt   3120

gtctagtaaa aattgtaatt gaatatgttt aaatatttaa tttctcattt tggggggttt   3180

ttattttttt attttttaga tggtgtctca cgctatcgcc caggctggag tgcagtggcg   3240

cgaactcggc tcactgcaac ctccgcctcc tgggttcaag caattctcct tcctcagcct   3300

cccaagtagc tgggattaca ggcatgcacc accatgccca gctaattttt gtatttttag   3360

tagagatgga attttgccat gttggccagg ctggtcttga actcctgacc tcaggggtga   3420

tccacccgcc tcgggctccc aaagtgctgt gattacaggc atgagccacc atgcctggcc   3480

tttgggggga ttttaattac agtattaatt atagttctag gatttcccac attttatagt   3540

agtagtttgc aggatattat gtgccctaat tagcagatat agacattatc aaattataat   3600

gatagtataa ttatcccttt ttaatattgg ggaaagaaaa atgaaaattc attagttaat   3660

tactgctttg tgttgtgtga atttattaac aaataacatt attacatata ggtcattgtt   3720

aacaaacaaa catccctgaa aacctctgtg aaaatttaat tttttatatc ctgattaata   3780

tattgtgact ttaggcccat ttttcatgtg cttcactttg atagagttaa tccataaaat   3840

tgctctttac tttagcttat caaatgaagt attattttgt ggactggagg ccaaaaagtc   3900

aatgtgagct tctcacaggt ttttaaagct ccactaaaaa taattatcca cttgtcttta   3960

cttttgttga ccagaatagt tggtaactct gccagagcct gtacttacct gccaaaaaca   4020

attaaatctg gttaatgcct gaaaccaaat ctctcagtct caagtgttat actatccaag   4080

ttttaaatgg aaaggtaaac tgtggagtaa tgaaattttg gttttactgt accttttgct   4140

atcaagataa tattcatgtt tgaaatcttg tctttatttg gaatttagtt actgtctgct   4200

tttaaccttt gctttcctaa agaaagtttg agatccagag agttcaaggg attggggaaa   4260

gagaggcgtc aagtcatttg cactttgtac ctgtaagtta ggtaataaac tattatactc   4320

gtacttctgt gcctgaaggt tttgtggtag gtatactgag atgtataagc tgtactgttg   4380

cctttactaa actatttcat tgccctttgc agccattttt acttaggggt gatgctaaaa   4440

gatgagtgaa ttgagatatg tcaaaataga gtgatagagt gtttttaata tagagtctgc   4500

agattgtgaa agaagggtga aagaacgata aataggttca gtagaataaa tatataataa   4560

gaggaccaaa aaaaaaaatc acaccatctt actttttttt ttt                     4603


<210>  7092
<211>  375
<212>  PRT
<213>  Homosapiens

<400>  7092

Met Ser Tyr Asn Ile Leu Ser Gln Asp Leu Leu Glu Asp Asn Ser His 
1               5                   10                  15      


Leu Tyr Arg His Cys Arg Arg Pro Val Leu His Trp Ser Phe Arg Phe 
            20                  25                  30          


Pro Asn Ile Leu Lys Glu Ile Lys His Phe Asp Ala Asp Val Leu Cys 
        35                  40                  45              


Leu Gln Glu Val Gln Glu Asp His Tyr Gly Ala Glu Ile Arg Pro Ser 
    50                  55                  60                  


Leu Glu Ser Leu Gly Tyr His Cys Glu Tyr Lys Met Arg Thr Gly Arg 
65                  70                  75                  80  


Lys Pro Asp Gly Cys Ala Ile Cys Phe Lys His Ser Lys Phe Ser Leu 
                85                  90                  95      


Leu Ser Val Asn Pro Val Glu Phe Phe Arg Pro Asp Ile Ser Leu Leu 
            100                 105                 110         


Asp Arg Asp Asn Val Gly Leu Val Leu Leu Leu Gln Pro Lys Ile Pro 
        115                 120                 125             


Tyr Ala Ala Cys Pro Ala Ile Cys Val Ala Asn Thr His Leu Leu Tyr 
    130                 135                 140                 


Asn Pro Arg Arg Gly Asp Ile Lys Leu Thr Gln Leu Ala Met Leu Leu 
145                 150                 155                 160 


Ala Glu Ile Ser Ser Val Ala His Gln Lys Asp Gly Ser Phe Cys Pro 
                165                 170                 175     


Ile Val Met Cys Gly Asp Phe Asn Ser Val Pro Gly Ser Pro Leu Tyr 
            180                 185                 190         


Ser Phe Ile Lys Glu Gly Lys Leu Asn Tyr Glu Gly Leu Pro Ile Gly 
        195                 200                 205             


Lys Val Ser Gly Gln Glu Gln Ser Ser Arg Gly Gln Arg Ile Leu Ser 
    210                 215                 220                 


Ile Pro Ile Trp Pro Pro Asn Leu Gly Ile Ser Gln Asn Cys Val Tyr 
225                 230                 235                 240 


Glu Val Gln Gln Val Pro Lys Val Glu Lys Thr Asp Ser Asp Leu Thr 
                245                 250                 255     


Gln Thr Gln Leu Lys Gln Thr Glu Val Leu Val Thr Ala Glu Lys Leu 
            260                 265                 270         


Ser Ser Asn Leu Gln His His Phe Ser Leu Ser Ser Val Tyr Ser His 
        275                 280                 285             


Tyr Phe Pro Asp Thr Gly Ile Pro Glu Val Thr Thr Cys His Ser Arg 
    290                 295                 300                 


Ser Ala Ile Thr Val Asp Tyr Ile Phe Tyr Ser Ala Glu Lys Glu Asp 
305                 310                 315                 320 


Val Ala Gly His Pro Gly Ala Glu Val Ala Leu Val Gly Gly Leu Lys 
                325                 330                 335     


Leu Leu Ala Arg Leu Ser Leu Leu Thr Glu Gln Asp Leu Trp Thr Val 
            340                 345                 350         


Asn Gly Leu Pro Asn Glu Asn Asn Ser Ser Asp His Leu Pro Leu Leu 
        355                 360                 365             


Ala Lys Phe Arg Leu Glu Leu 
    370                 375 


<210>  7093
<211>  5121
<212>  DNA
<213>  Homosapiens

<400>  7093
aagtgttggg attacaggca tgagccaccg cacctggcca acaattttta atgtggatga     60

aaccacttta tattgcaaga agatgccatc taggacttca taactagaaa gaagaagtca    120

gtgcctggtt tcaaaggaca ggctgactct tttgttagga gctaatatag cttgttactt    180

taagttaaag tcagcattca ttgaccattc tgaaaatcct agggcactta aaaattatgc    240

taaatccact ctacctgtgc tatgtcagtg gaaaaacaaa gcttggggat gacagtgcat    300

ctgtttatgg catagaatat tttaagcaca ctgctgagac cactattcag aaaaacagat    360

tcctttccaa agattactgt tcgttcacaa ggcacctggt cacccaagag ctctgatgaa    420

gatgtacaag gaaatgaatg ttttttcatc cctgctaaca cggcatccat tctgcagcct    480

atggaatcaa ggagtaattt tgtacctaca ggtctcctta tttaagaaat acatttcata    540

ggctatagct gccatagaag tgatttctct gatggatctg gggaaagtaa attgcaaacc    600

tgcaaaggat tcagcatcct aaatgctatt cagaacattc gtgattcatg ggaggaggtc    660

aaaatatcac cattaaaaag agtttggtag aagttgattc cagccctcat ggatgacttt    720

gaggggttca agacttcagg ggaggaagta actgtagatg tggtggaaat agcaagagaa    780

ctagaagtgg agcctgaaga attaactgaa ttgtttcaat ctcatgataa aacttaaata    840

gatgaggagt tgcttcttat agatgagcag agtattttct tgagatgcat tctattcctg    900

gtgaagatgc tgtgaacatt gctgaaatta caacaaagga ttttaaatgt tacataaatt    960

taattgataa aacattggaa gggtttccaa ttttgaaaaa aagttccgtg gataaagtgc   1020

tgtcaaatag catcagatgc tacagaaaaa tcttttatga aaggaagcat caatggctgc   1080

agcaaatttc attgttgtct tattttaaga aattgccaca gccaaccccc actttaagca   1140

accatcaccc tgatcagcca gcagtcatta atatctaggc aagatcctcc acctgtaaaa   1200

agatgatgac tcactgaagg ctgagatgat tgttaggata ttttaacaat gaagtatttt   1260

taaattaagg tatgtatttt cttaggcata atgctattgc acacttagta aactacagta   1320

tagtataaac gcaacttaca tgcactggga aactgaaaaa attatgtgac ttgctttatt   1380

gagatactca ctttattgtg gtggcctgaa accaaacccg cagtacctgt gagcatgcct   1440

atatttgata caataggaac tatattgcag gtagtaaaaa atgatgaata gtgttagttc   1500

aaagcgatag atgatttgta tgtccaaatt aaagaaaagc atgtatggga aaaagattgt   1560

catttttatg taaatgataa gtgctttctg aattgtattt aaagaaaaga agattttata   1620

agtccaaaga atcacttaat acaatgaata aagggtaata atttaccact tttggattac   1680

cttttattta agacataaat ttttcaactc ataagctatt taaaatcttt tcacttaaga   1740

tacctgttga aattttgttt aggtatctgg ccaggaacag tcttcacggg gacaaagaat   1800

tttatctatt ccaatttggc ccccaaacct aggtatctca cagaactgtg tgtatgaggt   1860

acagcaggta ccaaaagtag aaaagacaga cagtgatctg acacaaacac agctgaagca   1920

aacagaggtc ctagtgacag ctgaaaaatt gtcttcaaat ttacagcacc atttcagttt   1980

gtcatctgtt tattcacatt actttcctga cactggaatt ccagaagtga ccacctgtca   2040

ttcccgaagt gccataactg tggattatat tttctactct gcagaaaagg aagatgttgc   2100

tgggcaccca ggagctgaag ttgctttggt tggtggcttg aaacttctag ctagactgtc   2160

acttcttaca gaacaagact tatggactgt taatggactt ccaaacgaaa ataactcttc   2220

agatcatctg cctttattgg caaagttcag acttgagctc tgactctctt tgatcacata   2280

ctaattttct ttccaatttg tattgttttt caaagaatgt aaagttctta agtgtatgca   2340

tgttgtttat ttttgcactg tggagattct gaagcggtta tgttagatgc tttgaaactc   2400

catatcagaa gaaataactt tataacaatt ttttttaata atgaaaaata ttttcgtgac   2460

aagtgagctc taaattctct ttattgtaaa agagatgtaa aggttttata ttctaaatcc   2520

tagtaaaatt gacagtgatt tttaaatata atgcatcttc ctttgtctgc ttagtaaaaa   2580

atttcatttc ataattttgg caagctctgt agtggatcca aagtatcttt gagttcttgc   2640

aaactacaag ttgtttcctt tccagaaggc ttgatttcat taggagaccc ctctattgag   2700

ttctaaatag tttatcttag aaagccttgg gtcattcaca ggtatccaac cagccattgt   2760

ttagtttgtt tttgaagggg tttgataatg ctttttaagt tgtacagaat gcttaatcca   2820

tcttattact gtcctgagcc atgtaatatg cctgcatcgt gttggggaaa tgtttgggaa   2880

atataagcca gcataacgtg taaagctcac tctttcaccc tggaacagac aagaggtggg   2940

cttaatagag gcagagactg gggatatacc tttgtttccc tagcattttt atttatttat   3000

ttttatttta ttttattttt tgagatggag tttcactctt gttgcccagg ctgggggtgc   3060

aatggcgcaa tctttgctca ctgcaacccc tgcctcccgg gctcaagcga ttctcctgcc   3120

tcagcctctc gagtagctgg gattacaggc atgcgtcacc actcccagct aattttgtat   3180

tttcagtaga gacagggttt ccccatgttg gttaggctgg tctcgaactc ccaacctcag   3240

gtgatccgcc cacctcagct ctcaaagtgc tgggattaca ggcgggagcc actgcacatg   3300

gcagcatttt ttaaaaattc agttttaaga tctctggttt aggggagaga ttttatttta   3360

ctgaaccagt tctatagaaa tttattttat taggaaattt gtctttggaa caaagtggca   3420

gctataaaat tatttttgtt aagcctcaga aatatgagga agcctgtaaa actctagtgg   3480

ggagatatta acttggagac ctaatgctct gtaaatagtc atttaaactg ttggttttag   3540

tggttttgtt tctaaaatgt tttcttttac cgtgatgcac cagtatgaga tggtgctgac   3600

actttctatg aagtggttat gagcaggttt aataaatcct ctatacaagt gtttgaatca   3660

attttaaaac ataaaaagtg gaaatttcct tttttgtaga cagtaggaac aaggaattat   3720

atgcattttt actaagtagt aattttacac tgaattgtaa atgtttttac agtgagtttt   3780

attaatagaa tgcttcacct taaattggaa aacaataata gtcttggact aagtctttgt   3840

actaaagcat ttgctataat tatttttaaa aaaacaaaca gatgaaaacc tcagagaagg   3900

catgtggatt ataagatttg tctagtaaaa attgtaattg aatatgttta aatatttaat   3960

ttctcatttt ggggggtttt tattttttta ttttttagat ggtgtctcac gctatcgccc   4020

aggctggagt gcagtggcgc gaactcggct cactgcaacc tccgcctcct gggttcaagc   4080

aattctcctt cctcagcctc ccaagtagct gggattacag gcatgcacca ccatgcccag   4140

ctaatttttg tatttttagt agagatggaa ttttgccatg ttggccaggc tggtcttgaa   4200

ctcctgacct caggggtgat ccacccgcct cgggctccca aagtgctgtg attacaggca   4260

tgagccacca tgcctggcct ttggggggat tttaattaca gtattaatta tagttctagg   4320

atttcccaca ttttatagta gtagtttgca ggatattatg tgccctaatt agcagatata   4380

gacattatca aattataatg atagtataat tatccctttt taatattggg gaaagaaaaa   4440

tgaaaattca ttagttaatt actgctttgt gttgtgtgaa tttattaaca aataacatta   4500

ttacatatag gtcattgtta acaaacaaac atccctgaaa acctctgtga aaatttaatt   4560

ttttatatcc tgattaatat attgtgactt taggcccatt tttcatgtgc ttcactttga   4620

tagagttaat ccataaaatt gctctttact ttagcttatc aaatgaagta ttattttgtg   4680

gactggaggc caaaaagtca atgtgagctt ctcacaggtt tttaaagctc cactaaaaat   4740

aattatccac ttgtctttac ttttgttgac cagaatagtt ggtaactctg ccagagcctg   4800

tacttacctg ccaaaaacaa ttaaatctgg ttaatgcctg aaaccaaatc tctcagtctc   4860

aagtgttata ctatccaagt tttaaatgga aaggtaaact gtggagtaat gaaattttgg   4920

ttttactgta ccttttgcta tcaagataat attcatgttt gaaatcttgt ctttatttgg   4980

aatttagtta ctgtctgctt ttaacctttg ctttcctaaa gaaagtttga gatccagaga   5040

gttcaaggga ttggggaaag agaggcgtca agtcatttgc actttgtacc tgtaagttag   5100

gtaataaact attatactcg t                                             5121


<210>  7094
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  7094

Met His Ser Ile Pro Gly Glu Asp Ala Val Asn Ile Ala Glu Ile Thr 
1               5                   10                  15      


Thr Lys Asp Phe Lys Cys Tyr Ile Asn Leu Ile Asp Lys Thr Leu Glu 
            20                  25                  30          


Gly Phe Pro Ile Leu Lys Lys Ser Ser Val Asp Lys Val Leu Ser Asn 
        35                  40                  45              


Ser Ile Arg Cys Tyr Arg Lys Ile Phe Tyr Glu Arg Lys His Gln Trp 
    50                  55                  60                  


Leu Gln Gln Ile Ser Leu Leu Ser Tyr Phe Lys Lys Leu Pro Gln Pro 
65                  70                  75                  80  


Thr Pro Thr Leu Ser Asn His His Pro Asp Gln Pro Ala Val Ile Asn 
                85                  90                  95      


Ile 
    


<210>  7095
<211>  4322
<212>  DNA
<213>  Homosapiens

<400>  7095
cggcgagact gcacctccca gcatgccttg cagccaggac tggagtcggt acttaagagt     60

gatggggttc cctagatact ttaggccgtc gcatcgatta tagagattga ggtggaaccc    120

ggggcctggg aactggacgc acgcggaggg cgaagatgga agcctggcgc tgtgtgagga    180

agggctacgg ccactgtgtg gtgggaagag gccggtgtga taaagcggaa ttgggaatat    240

atatgtagcc atgataaaga aaaaacgaag atcctaggag acaaaaatgt tgatcccaaa    300

tgtgaagaca gtgagaacaa gtttgacttt tcagtgatgt cctataatat actttcacaa    360

gatttactgg aagataactc tcacctttat agacattgcc ggcggccagt attacactgg    420

agttttaggt ttcccaatat tctgaaagaa attaaacatt ttgatgcaga cgtactttgt    480

ttgcaagaag ttcaagaaga tcattatgga gcagagatca ggccaagttt ggaatcactg    540

ggttatcact gtgaatataa gatgcggaca ggaaggaaac ctgatggctg tgctatttgc    600

ttcaaacatt ccaaattttc actcttgtca gtgaacccag tggaattctt ccgccctgat    660

atttctctgt tggacagaga caatgttgga ttagttttac tcttacagcc caaaattcca    720

tatgctgcct gccctgcaat ctgcgtagca aatacgcatc tgttgtataa tccaaggcga    780

ggtgatatta agctgacgca attggcaatg ctactggcag agatttccag tgttgcccac    840

cagaaagatg gcagcttctg ccctattgtt atgtgtggtg actttaattc tgttcctggt    900

tctccactat atagtttcat aaaggaagga aaattgaatt atgaaggact tcccatagga    960

aaggtatctg gccaggaaca gtcttcacgg ggacaaagaa ttttatctat tccaatttgg   1020

cccccaaacc taggtatctc acagaactgt gtgtatgagg tacagcaggt accaaaagta   1080

gaaaagacag acagtgatct gacacaaaca cagctgaagc aaacagaggt cctagtgaca   1140

gctgaaaaat tgtcttcaaa tttacagcac catttcagtt tgtcatctgt ttattcacat   1200

tactttcctg acactggaat tccagaagtg accacctgtc attcccgaag tgccataact   1260

gtggattata ttttctactc tgcagaaaag gaagatgttg ctgggcaccc aggagctgaa   1320

gttgctttgg ttggtggctt gaaacttcta gctagactgt cacttcttac agaacaagac   1380

ttatggactg ttaatggact tccaaacgaa aataactctt cagatcatct gcctttattg   1440

gcaaagttca gacttgagct ctgactctct ttgatcacat actaattttc tttccaattt   1500

gtattgtttt tcaaagaatg taaagttctt aagtgtatgc atgttgttta tttttgcact   1560

gtggagattc tgaagcggtt atgttagatg ctttgaaact ccatatcaga agaaataact   1620

ttataacaat tttttttaat aatgaaaaat attttcgtga caagtgagct ctaaattctc   1680

tttattgtaa aagagatgta aaggttttat attctaaatc ctagtaaaat tgacagtgat   1740

ttttaaatat aatgcatctt cctttgtctg cttagtaaaa aatttcattt cataattttg   1800

gcaagctctg tagtggatcc aaagtatctt tgagttcttg caaactacaa gttgtttcct   1860

ttccagaagg cttgatttca ttaggagacc cctctattga gttctaaata gtttatctta   1920

gaaagccttg ggtcattcac aggtatccaa ccagccattg tttagtttgt ttttgaaggg   1980

gtttgataat gctttttaag ttgtacagaa tgcttaatcc atcttattac tgtcctgagc   2040

catgtaatat gcctgcatcg tgttggggaa atgtttggga aatataagcc agcataacgt   2100

gtaaagctca ctctttcacc ctggaacaga caagaggtgg gcttaataga ggcagagact   2160

ggggatatac ctttgtttcc ctagcatttt tatttattta tttttatttt attttatttt   2220

ttgagatgga gtttcactct tgttgcccag gctgggggtg caatggcgca atctttgctc   2280

actgcaaccc ctgcctcccg ggctcaagcg attctcctgc ctcagcctct cgagtagctg   2340

ggattacagg catgcgtcac cactcccagc taattttgta ttttcagtag agacagggtt   2400

tccccatgtt ggttaggctg gtctcgaact cccaacctca ggtgatccgc ccacctcagc   2460

tctcaaagtg ctgggattac aggcgggagc cactgcacat ggcagcattt tttaaaaatt   2520

cagttttaag atctctggtt taggggagag attttatttt actgaaccag ttctatagaa   2580

atttatttta ttaggaaatt tgtctttgga acaaagtggc agctataaaa ttatttttgt   2640

taagcctcag aaatatgagg aagcctgtaa aactctagtg gggagatatt aacttggaga   2700

cctaatgctc tgtaaatagt catttaaact gttggtttta gtggttttgt ttctaaaatg   2760

ttttctttta ccgtgatgca ccagtatgag atggtgctga cactttctat gaagtggtta   2820

tgagcaggtt taataaatcc tctatacaag tgtttgaatc aattttaaaa cataaaaagt   2880

ggaaatttcc ttttttgtag acagtaggaa caaggaatta tatgcatttt tactaagtag   2940

taattttaca ctgaattgta aatgttttta cagtgagttt tattaataga atgcttcacc   3000

ttaaattgga aaacaataat agtcttggac taagtctttg tactaaagca tttgctataa   3060

ttatttttaa aaaaacaaac agatgaaaac ctcagagaag gcatgtggat tataagattt   3120

gtctagtaaa aattgtaatt gaatatgttt aaatatttaa tttctcattt tggggggttt   3180

ttattttttt attttttaga tggtgtctca cgctatcgcc caggctggag tgcagtggcg   3240

cgaactcggc tcactgcaac ctccgcctcc tgggttcaag caattctcct tcctcagcct   3300

cccaagtagc tgggattaca ggcatgcacc accatgccca gctaattttt gtatttttag   3360

tagagatgga attttgccat gttggccagg ctggtcttga actcctgacc tcaggggtga   3420

tccacccgcc tcgggctccc aaagtgctgt gattacaggc atgagccacc atgcctggcc   3480

tttgggggga ttttaattac agtattaatt atagttctag gatttcccac attttatagt   3540

agtagtttgc aggatattat gtgccctaat tagcagatat agacattatc aaattataat   3600

gatagtataa ttatcccttt ttaatattgg ggaaagaaaa atgaaaattc attagttaat   3660

tactgctttg tgttgtgtga atttattaac aaataacatt attacatata ggtcattgtt   3720

aacaaacaaa catccctgaa aacctctgtg aaaatttaat tttttatatc ctgattaata   3780

tattgtgact ttaggcccat ttttcatgtg cttcactttg atagagttaa tccataaaat   3840

tgctctttac tttagcttat caaatgaagt attattttgt ggactggagg ccaaaaagtc   3900

aatgtgagct tctcacaggt ttttaaagct ccactaaaaa taattatcca cttgtcttta   3960

cttttgttga ccagaatagt tggtaactct gccagagcct gtacttacct gccaaaaaca   4020

attaaatctg gttaatgcct gaaaccaaat ctctcagtct caagtgttat actatccaag   4080

ttttaaatgg aaaggtaaac tgtggagtaa tgaaattttg gttttactgt accttttgct   4140

atcaagataa tattcatgtt tgaaatcttg tctttatttg gaatttagtt actgtctgct   4200

tttaaccttt gctttcctaa agaaagtttg agatccagag agttcaaggg attggggaaa   4260

gagaggcgtc aagtcatttg cactttgtac ctgtaagtta ggtaataaac tattatactc   4320

gt                                                                  4322


<210>  7096
<211>  375
<212>  PRT
<213>  Homosapiens

<400>  7096

Met Ser Tyr Asn Ile Leu Ser Gln Asp Leu Leu Glu Asp Asn Ser His 
1               5                   10                  15      


Leu Tyr Arg His Cys Arg Arg Pro Val Leu His Trp Ser Phe Arg Phe 
            20                  25                  30          


Pro Asn Ile Leu Lys Glu Ile Lys His Phe Asp Ala Asp Val Leu Cys 
        35                  40                  45              


Leu Gln Glu Val Gln Glu Asp His Tyr Gly Ala Glu Ile Arg Pro Ser 
    50                  55                  60                  


Leu Glu Ser Leu Gly Tyr His Cys Glu Tyr Lys Met Arg Thr Gly Arg 
65                  70                  75                  80  


Lys Pro Asp Gly Cys Ala Ile Cys Phe Lys His Ser Lys Phe Ser Leu 
                85                  90                  95      


Leu Ser Val Asn Pro Val Glu Phe Phe Arg Pro Asp Ile Ser Leu Leu 
            100                 105                 110         


Asp Arg Asp Asn Val Gly Leu Val Leu Leu Leu Gln Pro Lys Ile Pro 
        115                 120                 125             


Tyr Ala Ala Cys Pro Ala Ile Cys Val Ala Asn Thr His Leu Leu Tyr 
    130                 135                 140                 


Asn Pro Arg Arg Gly Asp Ile Lys Leu Thr Gln Leu Ala Met Leu Leu 
145                 150                 155                 160 


Ala Glu Ile Ser Ser Val Ala His Gln Lys Asp Gly Ser Phe Cys Pro 
                165                 170                 175     


Ile Val Met Cys Gly Asp Phe Asn Ser Val Pro Gly Ser Pro Leu Tyr 
            180                 185                 190         


Ser Phe Ile Lys Glu Gly Lys Leu Asn Tyr Glu Gly Leu Pro Ile Gly 
        195                 200                 205             


Lys Val Ser Gly Gln Glu Gln Ser Ser Arg Gly Gln Arg Ile Leu Ser 
    210                 215                 220                 


Ile Pro Ile Trp Pro Pro Asn Leu Gly Ile Ser Gln Asn Cys Val Tyr 
225                 230                 235                 240 


Glu Val Gln Gln Val Pro Lys Val Glu Lys Thr Asp Ser Asp Leu Thr 
                245                 250                 255     


Gln Thr Gln Leu Lys Gln Thr Glu Val Leu Val Thr Ala Glu Lys Leu 
            260                 265                 270         


Ser Ser Asn Leu Gln His His Phe Ser Leu Ser Ser Val Tyr Ser His 
        275                 280                 285             


Tyr Phe Pro Asp Thr Gly Ile Pro Glu Val Thr Thr Cys His Ser Arg 
    290                 295                 300                 


Ser Ala Ile Thr Val Asp Tyr Ile Phe Tyr Ser Ala Glu Lys Glu Asp 
305                 310                 315                 320 


Val Ala Gly His Pro Gly Ala Glu Val Ala Leu Val Gly Gly Leu Lys 
                325                 330                 335     


Leu Leu Ala Arg Leu Ser Leu Leu Thr Glu Gln Asp Leu Trp Thr Val 
            340                 345                 350         


Asn Gly Leu Pro Asn Glu Asn Asn Ser Ser Asp His Leu Pro Leu Leu 
        355                 360                 365             


Ala Lys Phe Arg Leu Glu Leu 
    370                 375 


<210>  7097
<211>  4845
<212>  DNA
<213>  Homosapiens

<400>  7097
aagtgttggg attacaggca tgagccaccg cacctggcca acaattttta atgtggatga     60

aaccacttta tattgcaaga agatgccatc taggacttca taactagaaa gaagaagtca    120

gtgcctggtt tcaaaggaca ggctgactct tttgttagga gctaatatag cttgttactt    180

taagttaaag tcagcattca ttgaccattc tgaaaatcct agggcactta aaaattatgc    240

taaatccact ctacctgtgc tatgtcagtg gaaaaacaaa gcttggggat gacagtgcat    300

ctgtttatgg catagaatat tttaagcaca ctgctgagac cactattcag aaaaacagat    360

tcctttccaa agattactgt tcgttcacaa ggcacctggt cacccaagag ctctgatgaa    420

gatgtacaag gaaatgaatg ttttttcatc cctgctaaca cggcatccat tctgcagcct    480

atggaatcaa ggagtaattt tgtacctaca ggtctcctta tttaagaaat acatttcata    540

ggctatagct gccatagaag tgatttctct gatggatctg gggaaagtaa attgcaaacc    600

tgcaaaggat tcagcatcct aaatgctatt cagaacattc gtgattcatg ggaggaggtc    660

aaaatatcac cattaaaaag agtttggtag aagttgattc cagccctcat ggatgacttt    720

gaggggttca agacttcagg ggaggaagta actgtagatg tggtggaaat agcaagagaa    780

ctagaagtgg agcctgaaga attaactgaa ttgtttcaat ctcatgataa aacttaaata    840

gatgaggagt tgcttcttat agatgagcag agtattttct tgagatgcat tctattcctg    900

gtgaagatgc tgtgaacatt gctgaaatta caacaaagga ttttaaatgt tacataaatt    960

taattgataa aacattggaa gggtttccaa ttttgaaaaa aagttccgtg gataaagtgc   1020

tgtcaaatag catcagatgc tacagaaaaa tcttttatga aaggaagcat caatggctgc   1080

agcaaatttc attgttgtct tattttaaga aattgccaca gccaaccccc actttaagca   1140

accatcaccc tgatcagcca gcagtcatta atatctaggc aagatcctcc acctgtaaaa   1200

agatgatgac tcactgaagg ctgagatgat tgttaggata ttttaacaat gaagtatttt   1260

taaattaagg tatgtatttt cttaggcata atgctattgc acacttagta aactacagta   1320

tagtataaac gcaacttaca tgcactggga aactgaaaaa attatgtgac ttgctttatt   1380

gagatactca ctttattgtg gtggcctgaa accaaacccg cagtacctgt gagcatgcct   1440

atatttgata caataggaac tatattgcag gtagtaaaaa atgatgaata gtgttagttc   1500

aaagcgatag atgatttgta tgtccaaatt aaagaaaagc atgtatggga aaaagattgt   1560

catttttatg taaatgataa gtgctttctg aattgtattt aaagaaaaga agattttata   1620

agtccaaaga atcacttaat acaatgaata aagggtaata atttaccact tttggattac   1680

cttttattta agacataaat ttttcaactc ataagctatt taaaatcttt tcacttaaga   1740

tacctgttga aattttgttt aggtatctgg ccaggaacag tcttcacggg gacaaagaat   1800

tttatctatt ccaatttggc ccccaaacct aggtatctca cagaactgtg tgtatgaggt   1860

acagcaggta ccaaaagtag aaaagacaga cagtgatctg acacaaacac agctgaagca   1920

aacagaggtc ctagtgacag ctgaaaaatt gtcttcaaat ttacagcacc atttcagttt   1980

gtcatctgtt tattcacatt actttcctga cactggaatt ccagaagtga ccacctgtca   2040

ttcccgaagt gccataactg tggattatat tttctactct gcagaaaagg aagatgttgc   2100

tgggcaccca ggagctgaag ttgctttggt tggtggcttg aaacttctag ctagactgtc   2160

acttcttaca gaacaagact tatggactgt taatggactt ccaaacgaaa ataactcttc   2220

agatcatctg cctttattgg caaagttcag acttgagctc tgactctctt tgatcacata   2280

ctaattttct ttccaatttg tattgttttt caaagaatgt aaagttctta agtgtatgca   2340

tgttgtttat ttttgcactg tggagattct gaagcggtta tgttagatgc tttgaaactc   2400

catatcagaa gaaataactt tataacaatt ttttttaata atgaaaaata ttttcgtgac   2460

aagtgagctc taaattctct ttattgtaaa agagatgtaa aggttttata ttctaaatcc   2520

tagtaaaatt gacagtgatt tttaaatata atgcatcttc ctttgtctgc ttagtaaaaa   2580

atttcatttc ataattttgg caagctctgt agtggatcca aagtatcttt gagttcttgc   2640

aaactacaag ttgtttcctt tccagaaggc ttgatttcat taggagaccc ctctattgag   2700

ttctaaatag tttatcttag aaagccttgg gtcattcaca ggtatccaac cagccattgt   2760

ttagtttgtt tttgaagggg tttgataatg ctttttaagt tgtacagaat gcttaatcca   2820

tcttattact gtcctgagcc atgtaatatg cctgcatcgt gttggggaaa tgtttgggaa   2880

atataagcca gcataacgtg taaagctcac tctttcaccc tggaacagac aagaggtggg   2940

cttaatagag gcagagactg gggatatacc tttgtttccc tagcattttt atttatttat   3000

ttttatttta ttttattttt tgagatggag tttcactctt gttgcccagg ctgggggtgc   3060

aatggcgcaa tctttgctca ctgcaacccc tgcctcccgg gctcaagcga ttctcctgcc   3120

tcagcctctc gagtagctgg gattacaggc atgcgtcacc actcccagct aattttgtat   3180

tttcagtaga gacagggttt ccccatgttg gttaggctgg tctcgaactc ccaacctcag   3240

gtgatccgcc cacctcagct ctcaaagtgc tgggattaca ggcgggagcc actgcacatg   3300

gcagcatttt ttaaaaattc agttttaaga tctctggttt aggggagaga ttttatttta   3360

ctgaaccagt tctatagaaa tttattttat taggaaattt gtctttggaa caaagtggca   3420

gctataaaat tatttttgtt aagcctcaga aatatgagga agcctgtaaa actctagtgg   3480

ggagatatta acttggagac ctaatgctct gtaaatagtc atttaaactg ttggttttag   3540

tggttttgtt tctaaaatgt tttcttttac cgtgatgcac cagtatgaga tggtgctgac   3600

actttctatg aagtggttat gagcaggttt aataaatcct ctatacaagt gtttgaatca   3660

attttaaaac ataaaaagtg gaaatttcct tttttgtaga cagtaggaac aaggaattat   3720

atgcattttt actaagtagt aattttacac tgaattgtaa atgtttttac agtgagtttt   3780

attaatagaa tgcttcacct taaattggaa aacaataata gtcttggact aagtctttgt   3840

actaaagcat ttgctataat tatttttaaa aaaacaaaca gatgaaaacc tcagagaagg   3900

catgtggatt ataagatttg tctagtaaaa attgtaattg aatatgttta aatatttaat   3960

ttctcatttt ggggggtttt tattttttta ttttttagat ggtgtctcac gctatcgccc   4020

aggctggagt gcagtggcgc gaactcggct cactgcaacc tccgcctcct gggttcaagc   4080

aattctcctt cctcagcctc ccaagtagct gggattacag gcatgcacca ccatgcccag   4140

ctaatttttg tatttttagt agagatggaa ttttgccatg ttggccaggc tggtcttgaa   4200

ctcctgacct caggggtgat ccacccgcct cgggctccca aagtgctgtg attacaggca   4260

tgagccacca tgcctggcct ttggggggat tttaattaca gtattaatta tagttctagg   4320

atttcccaca ttttatagta gtagtttgca ggatattatg tgccctaatt agcagatata   4380

gacattatca aattataatg atagtataat tatccctttt taatattggg gaaagaaaaa   4440

tgaaaattca ttagttaatt actgctttgt gttgtgtgaa tttattaaca aataacatta   4500

ttacatatag gtcattgtta acaaacaaac atccctgaaa acctctgtga aaatttaatt   4560

ttttatatcc tgattaatat attgtgactt taggcccatt tttcatgtgc ttcactttga   4620

tagagttaat ccataaaatt gctctttact ttagcttatc aaatgaagta ttattttgtg   4680

gactggaggc caaaaagtca atgtgagctt ctcacaggtt tttaaagctc cactaaaaat   4740

aattatccac ttgtctttac ttttgttgac cagaatagtt ggtaactctg ccagagcctg   4800

tacttacctg ccaaaaacaa ttaaatctgg ttaatgcctg aaacc                   4845


<210>  7098
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  7098

Met His Ser Ile Pro Gly Glu Asp Ala Val Asn Ile Ala Glu Ile Thr 
1               5                   10                  15      


Thr Lys Asp Phe Lys Cys Tyr Ile Asn Leu Ile Asp Lys Thr Leu Glu 
            20                  25                  30          


Gly Phe Pro Ile Leu Lys Lys Ser Ser Val Asp Lys Val Leu Ser Asn 
        35                  40                  45              


Ser Ile Arg Cys Tyr Arg Lys Ile Phe Tyr Glu Arg Lys His Gln Trp 
    50                  55                  60                  


Leu Gln Gln Ile Ser Leu Leu Ser Tyr Phe Lys Lys Leu Pro Gln Pro 
65                  70                  75                  80  


Thr Pro Thr Leu Ser Asn His His Pro Asp Gln Pro Ala Val Ile Asn 
                85                  90                  95      


Ile 
    


<210>  7099
<211>  4372
<212>  DNA
<213>  Homosapiens

<400>  7099
cggcgagact gcacctccca gcatgccttg cagccaggac tggagtcggt acttaagagt     60

gatggggttc cctagatact ttaggccgtc gcatcgatta tagagattga ggtggaaccc    120

ggggcctggg aactggacgc acgcggaggg cgaagatgga agcctggcgc tgtgtgagga    180

agggctacgg ccactgtgtg gtgggaagag gccgataccc catgtttccc catcactcga    240

ggagtctggg cagagactgg actacaccgt gggagaatct gcaaaggtgt tgctggaaca    300

gacatatttc tagttgtatg aggtggcctg gacattactc tcgagctcct tacccatact    360

tcagtagtag gcatttttca ctaaattgga gaccaccctg tttgtttgag tctagaactc    420

agttccagta ctgtaactgg agacctgaca acctgagcca gacatctttg attcatctct    480

ctagttacgt catgaacgct gagggagatg agccttcatc aaaacgaaga aaacaccaag    540

gtgtgataaa gcggaattgg gaatatatat gtagccatga taaagaaaaa acgaagatcc    600

taggagacaa aaatgttgat cccaaatgtg aagacagtga gaacaagttt gacttttcag    660

tgatgtccta taatatactt tcacaagatt tactggaaga taactctcac ctttatagac    720

attgccggcg gccagtatta cactggagtt ttaggtttcc caatattctg aaagaaatta    780

aacattttga tgcagacgta ctttgtttgc aagaagttca agaagatcat tatggagcag    840

agatcaggcc aagtttggaa tcactgggtt atcactgtga atataagatg cggacaggaa    900

ggaaacctga tggctgtgct atttgcttca aacattccaa attttcactc ttgtcagtga    960

acccagtgga attcttccgc cctgatattt ctctgttgga cagagacaat gttggattag   1020

ttttactctt acagcccaaa attccatatg ctgcctgccc tgcaatctgc gtagcaaata   1080

cgcatctgtt gtataatcca aggcgaggtg atattaagct gacgcaattg gcaatgctac   1140

tggcagagat ttccagtgtt gcccaccaga aagatggcag cttctgccct attgttatgt   1200

gtggtgactt taattctgtt cctggttctc cactatatag tttcataaag gaaggaaaat   1260

tgaattatga aggacttccc ataggaaagg tatctggcca ggaacagtct tcacggggac   1320

aaagaatttt atctattcca atttggcccc caaacctagg tatctcacag aactgtgtgt   1380

atgaggtaca gcaggtacca aaagtagaaa agacagacag tgatctgaca caaacacagc   1440

tgaagcaaac agaggtccta gtgacagctg aaaaattgtc ttcaaattta cagcaccatt   1500

tcagtttgtc atctgtttat tcacattact ttcctgacac tggaattcca gaagtgacca   1560

cctgtcattc ccgaagtgcc ataactgtgg attatatttt ctactctgca gaaaaggaag   1620

atgttgctgg gcacccagga gctgaagttg ctttggttgg tggcttgaaa cttctagcta   1680

gactgtcact tcttacagaa caagacttat ggactgttaa tggacttcca aacgaaaata   1740

actcttcaga tcatctgcct ttattggcaa agttcagact tgagctctga ctctctttga   1800

tcacatacta attttctttc caatttgtat tgtttttcaa agaatgtaaa gttcttaagt   1860

gtatgcatgt tgtttatttt tgcactgtgg agattctgaa gcggttatgt tagatgcttt   1920

gaaactccat atcagaagaa ataactttat aacaattttt tttaataatg aaaaatattt   1980

tcgtgacaag tgagctctaa attctcttta ttgtaaaaga gatgtaaagg ttttatattc   2040

taaatcctag taaaattgac agtgattttt aaatataatg catcttcctt tgtctgctta   2100

gtaaaaaatt tcatttcata attttggcaa gctctgtagt ggatccaaag tatctttgag   2160

ttcttgcaaa ctacaagttg tttcctttcc agaaggcttg atttcattag gagacccctc   2220

tattgagttc taaatagttt atcttagaaa gccttgggtc attcacaggt atccaaccag   2280

ccattgttta gtttgttttt gaaggggttt gataatgctt tttaagttgt acagaatgct   2340

taatccatct tattactgtc ctgagccatg taatatgcct gcatcgtgtt ggggaaatgt   2400

ttgggaaata taagccagca taacgtgtaa agctcactct ttcaccctgg aacagacaag   2460

aggtgggctt aatagaggca gagactgggg atataccttt gtttccctag catttttatt   2520

tatttatttt tattttattt tattttttga gatggagttt cactcttgtt gcccaggctg   2580

ggggtgcaat ggcgcaatct ttgctcactg caacccctgc ctcccgggct caagcgattc   2640

tcctgcctca gcctctcgag tagctgggat tacaggcatg cgtcaccact cccagctaat   2700

tttgtatttt cagtagagac agggtttccc catgttggtt aggctggtct cgaactccca   2760

acctcaggtg atccgcccac ctcagctctc aaagtgctgg gattacaggc gggagccact   2820

gcacatggca gcatttttta aaaattcagt tttaagatct ctggtttagg ggagagattt   2880

tattttactg aaccagttct atagaaattt attttattag gaaatttgtc tttggaacaa   2940

agtggcagct ataaaattat ttttgttaag cctcagaaat atgaggaagc ctgtaaaact   3000

ctagtgggga gatattaact tggagaccta atgctctgta aatagtcatt taaactgttg   3060

gttttagtgg ttttgtttct aaaatgtttt cttttaccgt gatgcaccag tatgagatgg   3120

tgctgacact ttctatgaag tggttatgag caggtttaat aaatcctcta tacaagtgtt   3180

tgaatcaatt ttaaaacata aaaagtggaa atttcctttt ttgtagacag taggaacaag   3240

gaattatatg catttttact aagtagtaat tttacactga attgtaaatg tttttacagt   3300

gagttttatt aatagaatgc ttcaccttaa attggaaaac aataatagtc ttggactaag   3360

tctttgtact aaagcatttg ctataattat ttttaaaaaa acaaacagat gaaaacctca   3420

gagaaggcat gtggattata agatttgtct agtaaaaatt gtaattgaat atgtttaaat   3480

atttaatttc tcattttggg gggtttttat ttttttattt tttagatggt gtctcacgct   3540

atcgcccagg ctggagtgca gtggcgcgaa ctcggctcac tgcaacctcc gcctcctggg   3600

ttcaagcaat tctccttcct cagcctccca agtagctggg attacaggca tgcaccacca   3660

tgcccagcta atttttgtat ttttagtaga gatggaattt tgccatgttg gccaggctgg   3720

tcttgaactc ctgacctcag gggtgatcca cccgcctcgg gctcccaaag tgctgtgatt   3780

acaggcatga gccaccatgc ctggcctttg gggggatttt aattacagta ttaattatag   3840

ttctaggatt tcccacattt tatagtagta gtttgcagga tattatgtgc cctaattagc   3900

agatatagac attatcaaat tataatgata gtataattat ccctttttaa tattggggaa   3960

agaaaaatga aaattcatta gttaattact gctttgtgtt gtgtgaattt attaacaaat   4020

aacattatta catataggtc attgttaaca aacaaacatc cctgaaaacc tctgtgaaaa   4080

tttaattttt tatatcctga ttaatatatt gtgactttag gcccattttt catgtgcttc   4140

actttgatag agttaatcca taaaattgct ctttacttta gcttatcaaa tgaagtatta   4200

ttttgtggac tggaggccaa aaagtcaatg tgagcttctc acaggttttt aaagctccac   4260

taaaaataat tatccacttg tctttacttt tgttgaccag aatagttggt aactctgcca   4320

gagcctgtac ttacctgcca aaaacaatta aatctggtta atgcctgaaa cc           4372


<210>  7100
<211>  544
<212>  PRT
<213>  Homosapiens

<400>  7100

Met Glu Ala Trp Arg Cys Val Arg Lys Gly Tyr Gly His Cys Val Val 
1               5                   10                  15      


Gly Arg Gly Arg Tyr Pro Met Phe Pro His His Ser Arg Ser Leu Gly 
            20                  25                  30          


Arg Asp Trp Thr Thr Pro Trp Glu Asn Leu Gln Arg Cys Cys Trp Asn 
        35                  40                  45              


Arg His Ile Ser Ser Cys Met Arg Trp Pro Gly His Tyr Ser Arg Ala 
    50                  55                  60                  


Pro Tyr Pro Tyr Phe Ser Ser Arg His Phe Ser Leu Asn Trp Arg Pro 
65                  70                  75                  80  


Pro Cys Leu Phe Glu Ser Arg Thr Gln Phe Gln Tyr Cys Asn Trp Arg 
                85                  90                  95      


Pro Asp Asn Leu Ser Gln Thr Ser Leu Ile His Leu Ser Ser Tyr Val 
            100                 105                 110         


Met Asn Ala Glu Gly Asp Glu Pro Ser Ser Lys Arg Arg Lys His Gln 
        115                 120                 125             


Gly Val Ile Lys Arg Asn Trp Glu Tyr Ile Cys Ser His Asp Lys Glu 
    130                 135                 140                 


Lys Thr Lys Ile Leu Gly Asp Lys Asn Val Asp Pro Lys Cys Glu Asp 
145                 150                 155                 160 


Ser Glu Asn Lys Phe Asp Phe Ser Val Met Ser Tyr Asn Ile Leu Ser 
                165                 170                 175     


Gln Asp Leu Leu Glu Asp Asn Ser His Leu Tyr Arg His Cys Arg Arg 
            180                 185                 190         


Pro Val Leu His Trp Ser Phe Arg Phe Pro Asn Ile Leu Lys Glu Ile 
        195                 200                 205             


Lys His Phe Asp Ala Asp Val Leu Cys Leu Gln Glu Val Gln Glu Asp 
    210                 215                 220                 


His Tyr Gly Ala Glu Ile Arg Pro Ser Leu Glu Ser Leu Gly Tyr His 
225                 230                 235                 240 


Cys Glu Tyr Lys Met Arg Thr Gly Arg Lys Pro Asp Gly Cys Ala Ile 
                245                 250                 255     


Cys Phe Lys His Ser Lys Phe Ser Leu Leu Ser Val Asn Pro Val Glu 
            260                 265                 270         


Phe Phe Arg Pro Asp Ile Ser Leu Leu Asp Arg Asp Asn Val Gly Leu 
        275                 280                 285             


Val Leu Leu Leu Gln Pro Lys Ile Pro Tyr Ala Ala Cys Pro Ala Ile 
    290                 295                 300                 


Cys Val Ala Asn Thr His Leu Leu Tyr Asn Pro Arg Arg Gly Asp Ile 
305                 310                 315                 320 


Lys Leu Thr Gln Leu Ala Met Leu Leu Ala Glu Ile Ser Ser Val Ala 
                325                 330                 335     


His Gln Lys Asp Gly Ser Phe Cys Pro Ile Val Met Cys Gly Asp Phe 
            340                 345                 350         


Asn Ser Val Pro Gly Ser Pro Leu Tyr Ser Phe Ile Lys Glu Gly Lys 
        355                 360                 365             


Leu Asn Tyr Glu Gly Leu Pro Ile Gly Lys Val Ser Gly Gln Glu Gln 
    370                 375                 380                 


Ser Ser Arg Gly Gln Arg Ile Leu Ser Ile Pro Ile Trp Pro Pro Asn 
385                 390                 395                 400 


Leu Gly Ile Ser Gln Asn Cys Val Tyr Glu Val Gln Gln Val Pro Lys 
                405                 410                 415     


Val Glu Lys Thr Asp Ser Asp Leu Thr Gln Thr Gln Leu Lys Gln Thr 
            420                 425                 430         


Glu Val Leu Val Thr Ala Glu Lys Leu Ser Ser Asn Leu Gln His His 
        435                 440                 445             


Phe Ser Leu Ser Ser Val Tyr Ser His Tyr Phe Pro Asp Thr Gly Ile 
    450                 455                 460                 


Pro Glu Val Thr Thr Cys His Ser Arg Ser Ala Ile Thr Val Asp Tyr 
465                 470                 475                 480 


Ile Phe Tyr Ser Ala Glu Lys Glu Asp Val Ala Gly His Pro Gly Ala 
                485                 490                 495     


Glu Val Ala Leu Val Gly Gly Leu Lys Leu Leu Ala Arg Leu Ser Leu 
            500                 505                 510         


Leu Thr Glu Gln Asp Leu Trp Thr Val Asn Gly Leu Pro Asn Glu Asn 
        515                 520                 525             


Asn Ser Ser Asp His Leu Pro Leu Leu Ala Lys Phe Arg Leu Glu Leu 
    530                 535                 540                 


<210>  7101
<211>  4046
<212>  DNA
<213>  Homosapiens

<400>  7101
cggcgagact gcacctccca gcatgccttg cagccaggac tggagtcggt acttaagagt     60

gatggggttc cctagatact ttaggccgtc gcatcgatta tagagattga ggtggaaccc    120

ggggcctggg aactggacgc acgcggaggg cgaagatgga agcctggcgc tgtgtgagga    180

agggctacgg ccactgtgtg gtgggaagag gccggtgtga taaagcggaa ttgggaatat    240

atatgtagcc atgataaaga aaaaacgaag atcctaggag acaaaaatgt tgatcccaaa    300

tgtgaagaca gtgagaacaa gtttgacttt tcagtgatgt cctataatat actttcacaa    360

gatttactgg aagataactc tcacctttat agacattgcc ggcggccagt attacactgg    420

agttttaggt ttcccaatat tctgaaagaa attaaacatt ttgatgcaga cgtactttgt    480

ttgcaagaag ttcaagaaga tcattatgga gcagagatca ggccaagttt ggaatcactg    540

ggttatcact gtgaatataa gatgcggaca ggaaggaaac ctgatggctg tgctatttgc    600

ttcaaacatt ccaaattttc actcttgtca gtgaacccag tggaattctt ccgccctgat    660

atttctctgt tggacagaga caatgttgga ttagttttac tcttacagcc caaaattcca    720

tatgctgcct gccctgcaat ctgcgtagca aatacgcatc tgttgtataa tccaaggcga    780

ggtgatatta agctgacgca attggcaatg ctactggcag agatttccag tgttgcccac    840

cagaaagatg gcagcttctg ccctattgtt atgtgtggtg actttaattc tgttcctggt    900

tctccactat atagtttcat aaaggaagga aaattgaatt atgaaggact tcccatagga    960

aaggtatctg gccaggaaca gtcttcacgg ggacaaagaa ttttatctat tccaatttgg   1020

cccccaaacc taggtatctc acagaactgt gtgtatgagg tacagcaggt accaaaagta   1080

gaaaagacag acagtgatct gacacaaaca cagctgaagc aaacagaggt cctagtgaca   1140

gctgaaaaat tgtcttcaaa tttacagcac catttcagtt tgtcatctgt ttattcacat   1200

tactttcctg acactggaat tccagaagtg accacctgtc attcccgaag tgccataact   1260

gtggattata ttttctactc tgcagaaaag gaagatgttg ctgggcaccc aggagctgaa   1320

gttgctttgg ttggtggctt gaaacttcta gctagactgt cacttcttac agaacaagac   1380

ttatggactg ttaatggact tccaaacgaa aataactctt cagatcatct gcctttattg   1440

gcaaagttca gacttgagct ctgactctct ttgatcacat actaattttc tttccaattt   1500

gtattgtttt tcaaagaatg taaagttctt aagtgtatgc atgttgttta tttttgcact   1560

gtggagattc tgaagcggtt atgttagatg ctttgaaact ccatatcaga agaaataact   1620

ttataacaat tttttttaat aatgaaaaat attttcgtga caagtgagct ctaaattctc   1680

tttattgtaa aagagatgta aaggttttat attctaaatc ctagtaaaat tgacagtgat   1740

ttttaaatat aatgcatctt cctttgtctg cttagtaaaa aatttcattt cataattttg   1800

gcaagctctg tagtggatcc aaagtatctt tgagttcttg caaactacaa gttgtttcct   1860

ttccagaagg cttgatttca ttaggagacc cctctattga gttctaaata gtttatctta   1920

gaaagccttg ggtcattcac aggtatccaa ccagccattg tttagtttgt ttttgaaggg   1980

gtttgataat gctttttaag ttgtacagaa tgcttaatcc atcttattac tgtcctgagc   2040

catgtaatat gcctgcatcg tgttggggaa atgtttggga aatataagcc agcataacgt   2100

gtaaagctca ctctttcacc ctggaacaga caagaggtgg gcttaataga ggcagagact   2160

ggggatatac ctttgtttcc ctagcatttt tatttattta tttttatttt attttatttt   2220

ttgagatgga gtttcactct tgttgcccag gctgggggtg caatggcgca atctttgctc   2280

actgcaaccc ctgcctcccg ggctcaagcg attctcctgc ctcagcctct cgagtagctg   2340

ggattacagg catgcgtcac cactcccagc taattttgta ttttcagtag agacagggtt   2400

tccccatgtt ggttaggctg gtctcgaact cccaacctca ggtgatccgc ccacctcagc   2460

tctcaaagtg ctgggattac aggcgggagc cactgcacat ggcagcattt tttaaaaatt   2520

cagttttaag atctctggtt taggggagag attttatttt actgaaccag ttctatagaa   2580

atttatttta ttaggaaatt tgtctttgga acaaagtggc agctataaaa ttatttttgt   2640

taagcctcag aaatatgagg aagcctgtaa aactctagtg gggagatatt aacttggaga   2700

cctaatgctc tgtaaatagt catttaaact gttggtttta gtggttttgt ttctaaaatg   2760

ttttctttta ccgtgatgca ccagtatgag atggtgctga cactttctat gaagtggtta   2820

tgagcaggtt taataaatcc tctatacaag tgtttgaatc aattttaaaa cataaaaagt   2880

ggaaatttcc ttttttgtag acagtaggaa caaggaatta tatgcatttt tactaagtag   2940

taattttaca ctgaattgta aatgttttta cagtgagttt tattaataga atgcttcacc   3000

ttaaattgga aaacaataat agtcttggac taagtctttg tactaaagca tttgctataa   3060

ttatttttaa aaaaacaaac agatgaaaac ctcagagaag gcatgtggat tataagattt   3120

gtctagtaaa aattgtaatt gaatatgttt aaatatttaa tttctcattt tggggggttt   3180

ttattttttt attttttaga tggtgtctca cgctatcgcc caggctggag tgcagtggcg   3240

cgaactcggc tcactgcaac ctccgcctcc tgggttcaag caattctcct tcctcagcct   3300

cccaagtagc tgggattaca ggcatgcacc accatgccca gctaattttt gtatttttag   3360

tagagatgga attttgccat gttggccagg ctggtcttga actcctgacc tcaggggtga   3420

tccacccgcc tcgggctccc aaagtgctgt gattacaggc atgagccacc atgcctggcc   3480

tttgggggga ttttaattac agtattaatt atagttctag gatttcccac attttatagt   3540

agtagtttgc aggatattat gtgccctaat tagcagatat agacattatc aaattataat   3600

gatagtataa ttatcccttt ttaatattgg ggaaagaaaa atgaaaattc attagttaat   3660

tactgctttg tgttgtgtga atttattaac aaataacatt attacatata ggtcattgtt   3720

aacaaacaaa catccctgaa aacctctgtg aaaatttaat tttttatatc ctgattaata   3780

tattgtgact ttaggcccat ttttcatgtg cttcactttg atagagttaa tccataaaat   3840

tgctctttac tttagcttat caaatgaagt attattttgt ggactggagg ccaaaaagtc   3900

aatgtgagct tctcacaggt ttttaaagct ccactaaaaa taattatcca cttgtcttta   3960

cttttgttga ccagaatagt tggtaactct gccagagcct gtacttacct gccaaaaaca   4020

attaaatctg gttaatgcct gaaacc                                        4046


<210>  7102
<211>  375
<212>  PRT
<213>  Homosapiens

<400>  7102

Met Ser Tyr Asn Ile Leu Ser Gln Asp Leu Leu Glu Asp Asn Ser His 
1               5                   10                  15      


Leu Tyr Arg His Cys Arg Arg Pro Val Leu His Trp Ser Phe Arg Phe 
            20                  25                  30          


Pro Asn Ile Leu Lys Glu Ile Lys His Phe Asp Ala Asp Val Leu Cys 
        35                  40                  45              


Leu Gln Glu Val Gln Glu Asp His Tyr Gly Ala Glu Ile Arg Pro Ser 
    50                  55                  60                  


Leu Glu Ser Leu Gly Tyr His Cys Glu Tyr Lys Met Arg Thr Gly Arg 
65                  70                  75                  80  


Lys Pro Asp Gly Cys Ala Ile Cys Phe Lys His Ser Lys Phe Ser Leu 
                85                  90                  95      


Leu Ser Val Asn Pro Val Glu Phe Phe Arg Pro Asp Ile Ser Leu Leu 
            100                 105                 110         


Asp Arg Asp Asn Val Gly Leu Val Leu Leu Leu Gln Pro Lys Ile Pro 
        115                 120                 125             


Tyr Ala Ala Cys Pro Ala Ile Cys Val Ala Asn Thr His Leu Leu Tyr 
    130                 135                 140                 


Asn Pro Arg Arg Gly Asp Ile Lys Leu Thr Gln Leu Ala Met Leu Leu 
145                 150                 155                 160 


Ala Glu Ile Ser Ser Val Ala His Gln Lys Asp Gly Ser Phe Cys Pro 
                165                 170                 175     


Ile Val Met Cys Gly Asp Phe Asn Ser Val Pro Gly Ser Pro Leu Tyr 
            180                 185                 190         


Ser Phe Ile Lys Glu Gly Lys Leu Asn Tyr Glu Gly Leu Pro Ile Gly 
        195                 200                 205             


Lys Val Ser Gly Gln Glu Gln Ser Ser Arg Gly Gln Arg Ile Leu Ser 
    210                 215                 220                 


Ile Pro Ile Trp Pro Pro Asn Leu Gly Ile Ser Gln Asn Cys Val Tyr 
225                 230                 235                 240 


Glu Val Gln Gln Val Pro Lys Val Glu Lys Thr Asp Ser Asp Leu Thr 
                245                 250                 255     


Gln Thr Gln Leu Lys Gln Thr Glu Val Leu Val Thr Ala Glu Lys Leu 
            260                 265                 270         


Ser Ser Asn Leu Gln His His Phe Ser Leu Ser Ser Val Tyr Ser His 
        275                 280                 285             


Tyr Phe Pro Asp Thr Gly Ile Pro Glu Val Thr Thr Cys His Ser Arg 
    290                 295                 300                 


Ser Ala Ile Thr Val Asp Tyr Ile Phe Tyr Ser Ala Glu Lys Glu Asp 
305                 310                 315                 320 


Val Ala Gly His Pro Gly Ala Glu Val Ala Leu Val Gly Gly Leu Lys 
                325                 330                 335     


Leu Leu Ala Arg Leu Ser Leu Leu Thr Glu Gln Asp Leu Trp Thr Val 
            340                 345                 350         


Asn Gly Leu Pro Asn Glu Asn Asn Ser Ser Asp His Leu Pro Leu Leu 
        355                 360                 365             


Ala Lys Phe Arg Leu Glu Leu 
    370                 375 


<210>  7103
<211>  2076
<212>  DNA
<213>  Homosapiens

<400>  7103
cggcgagact gcacctccca gcatgccttg cagccaggac tggagtcggt acttaagagt     60

gatggggttc cctagatact ttaggccgtc gcatcgatta tagagattga ggtggaaccc    120

ggggcctggg aactggacgc acgcggaggg cgaagatgga agcctggcgc tgtgtgagga    180

agggctacgg ccactgtgtg gtgggaagag gccgataccc catgtttccc catcactcga    240

ggagtctggg cagagactgg actacaccgt gggagaatct gcaaaggtgt tgctggaaca    300

gacatatttc tagttgtatg aggtggcctg gacattactc tcgagctcct tacccatact    360

tcagtagtag gcatttttca ctaaattgga gaccaccctg tttgtttgag tctagaactc    420

agttccagta ctgtaactgg agacctgaca acctgagcca gacatctttg attcatctct    480

ctagttacgt catgaacgct gagggagatg agccttcatc aaaacgaaga aaacaccaag    540

gtgtgataaa gcggaattgg gaatatatat gtagccatga taaagaaaaa acgaagatcc    600

taggagacaa aaatgttgat cccaaatgtg aagacagtga gaacaagttt gacttttcag    660

tgatgtccta taatatactt tcacaagatt tactggaaga taactctcac ctttatagac    720

attgccggcg gccagtatta cactggagtt ttaggtttcc caatattctg aaagaaatta    780

aacattttga tgcagacgta ctttgtttgc aagaagttca agaagatcat tatggagcag    840

agatcaggcc aagtttggaa tcactgggtt atcactgtga atataagatg cggacaggaa    900

ggaaacctga tggctgtgct atttgcttca aacattccaa attttcactc ttgtcagtga    960

acccagtgga attcttccgc cctgatattt ctctgttgga cagagacaat gttggattag   1020

ttttactctt acagcccaaa attccatatg ctgcctgccc tgcaatctgc gtagcaaata   1080

cgcatctgtt gtataatcca aggcgaggtg atattaagct gacgcaattg gcaatgctac   1140

tggcagagat ttccagtgtt gcccaccaga aagatggcag cttctgccct attgttatgt   1200

gtggtgactt taattctgtt cctggttctc cactatatag tttcataaag gaaggaaaat   1260

tgaattatga aggacttccc ataggaaagg tatctggcca ggaacagtct tcacggggac   1320

aaagaatttt atctattcca atttggcccc caaacctagg tatctcacag aactgtgtgt   1380

atgaggtaca gcaggtacca aaagtagaaa agacagacag tgatctgaca caaacacagc   1440

tgaagcaaac agaggtccta gtgacagctg aaaaattgtc ttcaaattta cagcaccatt   1500

tcagtttgtc atctgtttat tcacattact ttcctgacac tggaattcca gaagtgacca   1560

cctgtcattc ccgaagtgcc ataactgtgg attatatttt ctactctgca gaaaaggaag   1620

atgttgctgg gcacccagga gctgaagttg ctttggttgg tggcttgaaa cttctagcta   1680

gactgtcact tcttacagaa caagacttat ggactgttaa tggacttcca aacgaaaata   1740

actcttcaga tcatctgcct ttattggcaa agttcagact tgagctctga ctctctttga   1800

tcacatacta attttctttc caatttgtat tgtttttcaa agaatgtaaa gttcttaagt   1860

gtatgcatgt tgtttatttt tgcactgtgg agattctgaa gcggttatgt tagatgcttt   1920

gaaactccat atcagaagaa ataactttat aacaattttt tttaataatg aaaaatattt   1980

tcgtgacaag tgagctctaa attctcttta ttgtaaaaga gatgtaaagg ttttatattc   2040

taaatcctag taaaattgac agtgattttt aaatat                             2076


<210>  7104
<211>  544
<212>  PRT
<213>  Homosapiens

<400>  7104

Met Glu Ala Trp Arg Cys Val Arg Lys Gly Tyr Gly His Cys Val Val 
1               5                   10                  15      


Gly Arg Gly Arg Tyr Pro Met Phe Pro His His Ser Arg Ser Leu Gly 
            20                  25                  30          


Arg Asp Trp Thr Thr Pro Trp Glu Asn Leu Gln Arg Cys Cys Trp Asn 
        35                  40                  45              


Arg His Ile Ser Ser Cys Met Arg Trp Pro Gly His Tyr Ser Arg Ala 
    50                  55                  60                  


Pro Tyr Pro Tyr Phe Ser Ser Arg His Phe Ser Leu Asn Trp Arg Pro 
65                  70                  75                  80  


Pro Cys Leu Phe Glu Ser Arg Thr Gln Phe Gln Tyr Cys Asn Trp Arg 
                85                  90                  95      


Pro Asp Asn Leu Ser Gln Thr Ser Leu Ile His Leu Ser Ser Tyr Val 
            100                 105                 110         


Met Asn Ala Glu Gly Asp Glu Pro Ser Ser Lys Arg Arg Lys His Gln 
        115                 120                 125             


Gly Val Ile Lys Arg Asn Trp Glu Tyr Ile Cys Ser His Asp Lys Glu 
    130                 135                 140                 


Lys Thr Lys Ile Leu Gly Asp Lys Asn Val Asp Pro Lys Cys Glu Asp 
145                 150                 155                 160 


Ser Glu Asn Lys Phe Asp Phe Ser Val Met Ser Tyr Asn Ile Leu Ser 
                165                 170                 175     


Gln Asp Leu Leu Glu Asp Asn Ser His Leu Tyr Arg His Cys Arg Arg 
            180                 185                 190         


Pro Val Leu His Trp Ser Phe Arg Phe Pro Asn Ile Leu Lys Glu Ile 
        195                 200                 205             


Lys His Phe Asp Ala Asp Val Leu Cys Leu Gln Glu Val Gln Glu Asp 
    210                 215                 220                 


His Tyr Gly Ala Glu Ile Arg Pro Ser Leu Glu Ser Leu Gly Tyr His 
225                 230                 235                 240 


Cys Glu Tyr Lys Met Arg Thr Gly Arg Lys Pro Asp Gly Cys Ala Ile 
                245                 250                 255     


Cys Phe Lys His Ser Lys Phe Ser Leu Leu Ser Val Asn Pro Val Glu 
            260                 265                 270         


Phe Phe Arg Pro Asp Ile Ser Leu Leu Asp Arg Asp Asn Val Gly Leu 
        275                 280                 285             


Val Leu Leu Leu Gln Pro Lys Ile Pro Tyr Ala Ala Cys Pro Ala Ile 
    290                 295                 300                 


Cys Val Ala Asn Thr His Leu Leu Tyr Asn Pro Arg Arg Gly Asp Ile 
305                 310                 315                 320 


Lys Leu Thr Gln Leu Ala Met Leu Leu Ala Glu Ile Ser Ser Val Ala 
                325                 330                 335     


His Gln Lys Asp Gly Ser Phe Cys Pro Ile Val Met Cys Gly Asp Phe 
            340                 345                 350         


Asn Ser Val Pro Gly Ser Pro Leu Tyr Ser Phe Ile Lys Glu Gly Lys 
        355                 360                 365             


Leu Asn Tyr Glu Gly Leu Pro Ile Gly Lys Val Ser Gly Gln Glu Gln 
    370                 375                 380                 


Ser Ser Arg Gly Gln Arg Ile Leu Ser Ile Pro Ile Trp Pro Pro Asn 
385                 390                 395                 400 


Leu Gly Ile Ser Gln Asn Cys Val Tyr Glu Val Gln Gln Val Pro Lys 
                405                 410                 415     


Val Glu Lys Thr Asp Ser Asp Leu Thr Gln Thr Gln Leu Lys Gln Thr 
            420                 425                 430         


Glu Val Leu Val Thr Ala Glu Lys Leu Ser Ser Asn Leu Gln His His 
        435                 440                 445             


Phe Ser Leu Ser Ser Val Tyr Ser His Tyr Phe Pro Asp Thr Gly Ile 
    450                 455                 460                 


Pro Glu Val Thr Thr Cys His Ser Arg Ser Ala Ile Thr Val Asp Tyr 
465                 470                 475                 480 


Ile Phe Tyr Ser Ala Glu Lys Glu Asp Val Ala Gly His Pro Gly Ala 
                485                 490                 495     


Glu Val Ala Leu Val Gly Gly Leu Lys Leu Leu Ala Arg Leu Ser Leu 
            500                 505                 510         


Leu Thr Glu Gln Asp Leu Trp Thr Val Asn Gly Leu Pro Asn Glu Asn 
        515                 520                 525             


Asn Ser Ser Asp His Leu Pro Leu Leu Ala Lys Phe Arg Leu Glu Leu 
    530                 535                 540                 


<210>  7105
<211>  4190
<212>  DNA
<213>  Homosapiens

<400>  7105
ggaagcagag ctgtgcagct gaggcgccgc cgtggagccg ccttggagcc accgccccct     60

cgccgcttcg ccgctgcgtt ggggaacctg gaccgcggcg gcgccgggtt tccctcatga    120

tcccgggcgg gtggcggcgg cggcagaggc ggcgggagga tgacctctta ccgggagcgg    180

agtgccgacc tggcccgttt ctacactgtc accgagcccc agcgacaccc gaggggctac    240

acagtatata aggtcaccgc ccgggttgtt tcacgaagaa atccagagga tgtccaggag    300

ataattgtat ggaagagata cagtgatttt aagaaactac acaaagaact atggcaaatt    360

cacaaaaact tattccgaca ttcagagttg tttcctccat ttgctaaagg aatagtgttt    420

gggcgatttg atgaaactgt tatcgaagag agaagacaat gtgctgaaga cctgctacag    480

ttctctgcca atattcctgc tctttacaat agtaaacagc ttgaagactt tttcaagggt    540

ggaataatta atgatagttc tgaattaatt ggtcctgctg aagctcactc agattccctc    600

attgatacct ttcctgagtg tagtacggaa ggcttctcca gtgacagtga tctggtatct    660

cttactgttg atgtggattc tcttgctgag ttagatgatg gaatggcttc caatcaaaat    720

tctcccatta gaacttttgg tctcaatctt tcttcggatt cttcagcact aggggctgtt    780

gcttctgaca gtgaacagag caaaacagaa gaagaacggg aaagtcgtag cctctttcct    840

ggcagtttaa agccgaagct tggcaagaga gattatttgg agaaagcagg agaattaata    900

aagctggctt taaaaaagga agaagaagac gactatgaag ctgcttctga tttttatagg    960

aagggagttg atttactcct agaaggtgtt caaggagagt caagccctac ccgtcgagaa   1020

gctgtgaaga gaagaacagc cgagtacctc atgcgggcag aaagtatctc tagtctttat   1080

gggaaacctc agcttgatga tgtatctcag cctccaggat cactaagttc aaggcccctt   1140

tggaacctaa ggagccctgc cgaggagctg aaggccttca gagtccttgg ggtgattgac   1200

aaggttttac ttgtaatgga cacaaggaca gaacagactt tcattttaaa aggtctaagg   1260

aaaagcagtg aatacagcag gaacagaaag accatcatcc cccgctgtgt gcccaacatg   1320

gtgtgtctgc ataagtacat catctctgag gagtcagtat ttcttgtgct gcagcatgcg   1380

gaaggtggca aactgtggtc atatatcagt aaatttctaa acagaagtcc tgaagaaagc   1440

tttgacatca aggaagtgaa aaaacctaca cttgcaaaag ttcacctgca gcagccaact   1500

tctagtcctc aggacagcag tagctttgaa tccagaggaa gtgatggtgg aagcatgctt   1560

aaagctctgc ctttgaagag tagtcttact ccaagttctc aagatgacag caaccaggaa   1620

gatgatggcc aagatagctc tccaaagtgg ccagattctg gttcaagttc agaagaagaa   1680

tgtactacta gttatttaac attatgcaat gaatatgggc aagaaaagat tgaaccaggg   1740

tctttgaatg aggagccctt catgaagact gaagggaatg gtgttgatac aaaagctatt   1800

aaaagcttcc cagcacacct tgctgctgac agtgacagcc ccagcacaca gctgagagct   1860

cacgagctga agttcttccc caacgatgac ccagaagcag ttagttctcc aagaacatca   1920

gattccctca gtagatcaaa aaatagcccc atggaattct ttaggataga cagtaaggat   1980

agcgcaagtg aactcctggg acttgacttt ggagaaaaat tgtatagtct aaaatcagaa   2040

cctttgaaac cattctttac tcttccagat ggagacagtg cttctaggag ttttaatact   2100

agtgaaagca aggtagagtt taaagctcag gacaccatta gcaggggctc agatgactca   2160

gtgccagtta tttcatttaa agatgctgct tttgatgatg tcagtggtac tgatgaagga   2220

agacctgatc ttcttgtaaa tttacctggt gaattggagt caacaagaga agctgcagca   2280

atgggaccta ctaagtttac acaaactaat atagggataa tagaaaataa actcttggaa   2340

gcccctgatg ttttatgcct caggcttagt actgaacaat gccaagcaca tgaggagaaa   2400

ggcatagagg aactgagtga tccctctggg cccaaatcct atagtataac agagaaacac   2460

tatgcacagg aggatcccag gatgttattt gtagcagctg ttgatcatag tagttcagga   2520

gatatgtctt tgttacccag ctcagatcct aagtttcaag gacttggagt ggttgagtca   2580

gcagtaactg caaacaacac agaagaaagc ttattccgta tttgtagtcc actctcaggt   2640

gctaatgaat atattgcaag cacagacact ttaaaaacag aagaagtatt gctgtttaca   2700

gatcagactg atgatttggc taaagaggaa ccaacttctt tattccagag agactctgag   2760

actaagggtg aaagtggttt agtgctagaa ggagacaagg aaatacatca gatttttgag   2820

gaccttgata aaaaattagc actagcctcc aggttttaca tcccagaggg ctgcattcaa   2880

agatgggcag ctgaaatggt ggtagccctt gatgctttac atagagaggg aattgtgtgc   2940

cgcgatttga acccaaacaa catcttattg aatgatagag gacacattca gctaacgtat   3000

tttagcaggt ggagtgaggt tgaagattcc tgtgacagcg atgccataga gagaatgtac   3060

tgtgccccag aggttggagc aatcactgaa gaaactgaag cctgtgattg gtggagtttg   3120

ggtgctgtcc tctttgaact tctcactggc aagactctgg ttgaatgcca tccagcagga   3180

ataaatactc acactacttt gaacatgcca gaatgtgtct ctgaagaggc tcgctcactc   3240

attcaacagc tcttgcagtt caatcctctg gaacgacttg gtgctggagt tgctggtgtt   3300

gaagatatca aatctcatcc attttttacc cctgtggatt gggcagaact gatgagatga   3360

acgtaatgca gggttatctt cacacattct gatcttctct gtgacaggca tctccagcac   3420

tgaggcacct ctgactcaca gttacttatg gagcaccaaa gcatttggat aaagaccgtt   3480

ataggaaatg ggggggaaat ggctaaaaga gaacaattcg tttacaatta caagatatta   3540

gctaattgtg ccaggggctg ttatatacat atatacacaa ccaaggtgtg atctgaattt   3600

aatccacatt tggtgttgca gatgagttgt aaagccaact gaaagagttc cttcaagaag   3660

ttcctctgat aggaagctag aagtgtagaa tgaagtttta cttgacagaa ggacctttac   3720

atggcagcta acagtgcttt ttgctgacca ggattggttt atatgattaa attaatattt   3780

gcttaataat acactaaaag tatatgaaca atgtcatcaa tgaaacttaa aagcgagaaa   3840

aaagaatata cacataattt ctgacggaaa acctgtaccc tgatgctgta taatgtatgt   3900

tgaatgtggt cccagattat ttctgtaaga agacactcca tgttgtcagc tttgtactct   3960

ttgttgatac tgcttattta gagaagggtt catataaaca ctcactctgt gtcttcaaca   4020

gcatctttct ttccccatct ttctattttc tgcaccctct gcttgttccc tcatattctg   4080

ttcttccgac tcctgctaac acacatgcaa caaaaaaggg aagggagtgc ttatttccct   4140

ttgtgtaagg actaagaaat catgatatca aataaacatg gtgaaacatt              4190


<210>  7106
<211>  1066
<212>  PRT
<213>  Homosapiens

<400>  7106

Met Thr Ser Tyr Arg Glu Arg Ser Ala Asp Leu Ala Arg Phe Tyr Thr 
1               5                   10                  15      


Val Thr Glu Pro Gln Arg His Pro Arg Gly Tyr Thr Val Tyr Lys Val 
            20                  25                  30          


Thr Ala Arg Val Val Ser Arg Arg Asn Pro Glu Asp Val Gln Glu Ile 
        35                  40                  45              


Ile Val Trp Lys Arg Tyr Ser Asp Phe Lys Lys Leu His Lys Glu Leu 
    50                  55                  60                  


Trp Gln Ile His Lys Asn Leu Phe Arg His Ser Glu Leu Phe Pro Pro 
65                  70                  75                  80  


Phe Ala Lys Gly Ile Val Phe Gly Arg Phe Asp Glu Thr Val Ile Glu 
                85                  90                  95      


Glu Arg Arg Gln Cys Ala Glu Asp Leu Leu Gln Phe Ser Ala Asn Ile 
            100                 105                 110         


Pro Ala Leu Tyr Asn Ser Lys Gln Leu Glu Asp Phe Phe Lys Gly Gly 
        115                 120                 125             


Ile Ile Asn Asp Ser Ser Glu Leu Ile Gly Pro Ala Glu Ala His Ser 
    130                 135                 140                 


Asp Ser Leu Ile Asp Thr Phe Pro Glu Cys Ser Thr Glu Gly Phe Ser 
145                 150                 155                 160 


Ser Asp Ser Asp Leu Val Ser Leu Thr Val Asp Val Asp Ser Leu Ala 
                165                 170                 175     


Glu Leu Asp Asp Gly Met Ala Ser Asn Gln Asn Ser Pro Ile Arg Thr 
            180                 185                 190         


Phe Gly Leu Asn Leu Ser Ser Asp Ser Ser Ala Leu Gly Ala Val Ala 
        195                 200                 205             


Ser Asp Ser Glu Gln Ser Lys Thr Glu Glu Glu Arg Glu Ser Arg Ser 
    210                 215                 220                 


Leu Phe Pro Gly Ser Leu Lys Pro Lys Leu Gly Lys Arg Asp Tyr Leu 
225                 230                 235                 240 


Glu Lys Ala Gly Glu Leu Ile Lys Leu Ala Leu Lys Lys Glu Glu Glu 
                245                 250                 255     


Asp Asp Tyr Glu Ala Ala Ser Asp Phe Tyr Arg Lys Gly Val Asp Leu 
            260                 265                 270         


Leu Leu Glu Gly Val Gln Gly Glu Ser Ser Pro Thr Arg Arg Glu Ala 
        275                 280                 285             


Val Lys Arg Arg Thr Ala Glu Tyr Leu Met Arg Ala Glu Ser Ile Ser 
    290                 295                 300                 


Ser Leu Tyr Gly Lys Pro Gln Leu Asp Asp Val Ser Gln Pro Pro Gly 
305                 310                 315                 320 


Ser Leu Ser Ser Arg Pro Leu Trp Asn Leu Arg Ser Pro Ala Glu Glu 
                325                 330                 335     


Leu Lys Ala Phe Arg Val Leu Gly Val Ile Asp Lys Val Leu Leu Val 
            340                 345                 350         


Met Asp Thr Arg Thr Glu Gln Thr Phe Ile Leu Lys Gly Leu Arg Lys 
        355                 360                 365             


Ser Ser Glu Tyr Ser Arg Asn Arg Lys Thr Ile Ile Pro Arg Cys Val 
    370                 375                 380                 


Pro Asn Met Val Cys Leu His Lys Tyr Ile Ile Ser Glu Glu Ser Val 
385                 390                 395                 400 


Phe Leu Val Leu Gln His Ala Glu Gly Gly Lys Leu Trp Ser Tyr Ile 
                405                 410                 415     


Ser Lys Phe Leu Asn Arg Ser Pro Glu Glu Ser Phe Asp Ile Lys Glu 
            420                 425                 430         


Val Lys Lys Pro Thr Leu Ala Lys Val His Leu Gln Gln Pro Thr Ser 
        435                 440                 445             


Ser Pro Gln Asp Ser Ser Ser Phe Glu Ser Arg Gly Ser Asp Gly Gly 
    450                 455                 460                 


Ser Met Leu Lys Ala Leu Pro Leu Lys Ser Ser Leu Thr Pro Ser Ser 
465                 470                 475                 480 


Gln Asp Asp Ser Asn Gln Glu Asp Asp Gly Gln Asp Ser Ser Pro Lys 
                485                 490                 495     


Trp Pro Asp Ser Gly Ser Ser Ser Glu Glu Glu Cys Thr Thr Ser Tyr 
            500                 505                 510         


Leu Thr Leu Cys Asn Glu Tyr Gly Gln Glu Lys Ile Glu Pro Gly Ser 
        515                 520                 525             


Leu Asn Glu Glu Pro Phe Met Lys Thr Glu Gly Asn Gly Val Asp Thr 
    530                 535                 540                 


Lys Ala Ile Lys Ser Phe Pro Ala His Leu Ala Ala Asp Ser Asp Ser 
545                 550                 555                 560 


Pro Ser Thr Gln Leu Arg Ala His Glu Leu Lys Phe Phe Pro Asn Asp 
                565                 570                 575     


Asp Pro Glu Ala Val Ser Ser Pro Arg Thr Ser Asp Ser Leu Ser Arg 
            580                 585                 590         


Ser Lys Asn Ser Pro Met Glu Phe Phe Arg Ile Asp Ser Lys Asp Ser 
        595                 600                 605             


Ala Ser Glu Leu Leu Gly Leu Asp Phe Gly Glu Lys Leu Tyr Ser Leu 
    610                 615                 620                 


Lys Ser Glu Pro Leu Lys Pro Phe Phe Thr Leu Pro Asp Gly Asp Ser 
625                 630                 635                 640 


Ala Ser Arg Ser Phe Asn Thr Ser Glu Ser Lys Val Glu Phe Lys Ala 
                645                 650                 655     


Gln Asp Thr Ile Ser Arg Gly Ser Asp Asp Ser Val Pro Val Ile Ser 
            660                 665                 670         


Phe Lys Asp Ala Ala Phe Asp Asp Val Ser Gly Thr Asp Glu Gly Arg 
        675                 680                 685             


Pro Asp Leu Leu Val Asn Leu Pro Gly Glu Leu Glu Ser Thr Arg Glu 
    690                 695                 700                 


Ala Ala Ala Met Gly Pro Thr Lys Phe Thr Gln Thr Asn Ile Gly Ile 
705                 710                 715                 720 


Ile Glu Asn Lys Leu Leu Glu Ala Pro Asp Val Leu Cys Leu Arg Leu 
                725                 730                 735     


Ser Thr Glu Gln Cys Gln Ala His Glu Glu Lys Gly Ile Glu Glu Leu 
            740                 745                 750         


Ser Asp Pro Ser Gly Pro Lys Ser Tyr Ser Ile Thr Glu Lys His Tyr 
        755                 760                 765             


Ala Gln Glu Asp Pro Arg Met Leu Phe Val Ala Ala Val Asp His Ser 
    770                 775                 780                 


Ser Ser Gly Asp Met Ser Leu Leu Pro Ser Ser Asp Pro Lys Phe Gln 
785                 790                 795                 800 


Gly Leu Gly Val Val Glu Ser Ala Val Thr Ala Asn Asn Thr Glu Glu 
                805                 810                 815     


Ser Leu Phe Arg Ile Cys Ser Pro Leu Ser Gly Ala Asn Glu Tyr Ile 
            820                 825                 830         


Ala Ser Thr Asp Thr Leu Lys Thr Glu Glu Val Leu Leu Phe Thr Asp 
        835                 840                 845             


Gln Thr Asp Asp Leu Ala Lys Glu Glu Pro Thr Ser Leu Phe Gln Arg 
    850                 855                 860                 


Asp Ser Glu Thr Lys Gly Glu Ser Gly Leu Val Leu Glu Gly Asp Lys 
865                 870                 875                 880 


Glu Ile His Gln Ile Phe Glu Asp Leu Asp Lys Lys Leu Ala Leu Ala 
                885                 890                 895     


Ser Arg Phe Tyr Ile Pro Glu Gly Cys Ile Gln Arg Trp Ala Ala Glu 
            900                 905                 910         


Met Val Val Ala Leu Asp Ala Leu His Arg Glu Gly Ile Val Cys Arg 
        915                 920                 925             


Asp Leu Asn Pro Asn Asn Ile Leu Leu Asn Asp Arg Gly His Ile Gln 
    930                 935                 940                 


Leu Thr Tyr Phe Ser Arg Trp Ser Glu Val Glu Asp Ser Cys Asp Ser 
945                 950                 955                 960 


Asp Ala Ile Glu Arg Met Tyr Cys Ala Pro Glu Val Gly Ala Ile Thr 
                965                 970                 975     


Glu Glu Thr Glu Ala Cys Asp Trp Trp Ser Leu Gly Ala Val Leu Phe 
            980                 985                 990         


Glu Leu Leu Thr Gly Lys Thr Leu  Val Glu Cys His Pro  Ala Gly Ile 
        995                 1000                 1005             


Asn Thr  His Thr Thr Leu Asn  Met Pro Glu Cys Val  Ser Glu Glu 
    1010                 1015                 1020             


Ala Arg  Ser Leu Ile Gln Gln  Leu Leu Gln Phe Asn  Pro Leu Glu 
    1025                 1030                 1035             


Arg Leu  Gly Ala Gly Val Ala  Gly Val Glu Asp Ile  Lys Ser His 
    1040                 1045                 1050             


Pro Phe  Phe Thr Pro Val Asp  Trp Ala Glu Leu Met  Arg 
    1055                 1060                 1065     


<210>  7107
<211>  5499
<212>  DNA
<213>  Homosapiens

<400>  7107
ggaagcagag ctgtgcagct gaggcgccgc cgtggagccg ccttggagcc accgccccct     60

cgccgcttcg ccgctgcgtt ggggaacctg gaccgcggcg gcgccgggtt tccctcatga    120

tcccgggcgg gtggcggcgg cggcagaggc ggcgggagga tgacctctta ccgggagcgg    180

agtgccgacc tggcccgttt ctacactgtc accgagcccc agcgacaccc gaggggctac    240

acagtatata aggtcaccgc ccgggttgtt tcacgaagaa atccagagga tgtccaggag    300

ataattgtat ggaagagata cagtgatttt aagaaactac acaaagaact atggcaaatt    360

cacaaaaact tattccgaca ttcagagttg tttcctccat ttgctaaagg aatagtgttt    420

gggcgatttg atgaaactgt tatcgaagag agaagacaat gtgctgaaga cctgctacag    480

ttctctgcca atattcctgc tctttacaat agtaaacagc ttgaagactt tttcaagggt    540

ggaataatta atgatagttc tgaattaatt ggtcctgctg aagctcactc agattccctc    600

attgatacct ttcctgagtg tagtacggaa ggcttctcca gtgacagtga tctggtatct    660

cttactgttg atgtggattc tcttgctgag ttagatgatg gaatggcttc caatcaaaat    720

tctcccatta gaacttttgg tctcaatctt tcttcggatt cttcagcact aggggctgtt    780

gcttctgaca gtgaacagag caaaacagaa gaagaacggg aaagtcgtag cctctttcct    840

ggcagtttaa agccgaagct tggcaagaga gattatttgg agaaagcagg agaattaata    900

aagctggctt taaaaaagga agaagaagac gactatgaag ctgcttctga tttttatagg    960

aagggagttg atttactcct agaaggtgtt caaggagagt caagccctac ccgtcgagaa   1020

gctgtgaaga gaagaacagc cgagtacctc atgcgggcag aaagtatctc tagtctttat   1080

gggaaacctc agcttgatga tgtatctcag cctccaggat cactaagttc aaggcccctt   1140

tggaacctaa ggagccctgc cgaggagctg aaggccttca gagtccttgg ggtgattgac   1200

aaggttttac ttgtaatgga cacaaggaca gaacagactt tcattttaaa aggtctaagg   1260

aaaagcagtg aatacagcag gaacagaaag accatcatcc cccgctgtgt gcccaacatg   1320

gtgtgtctgc ataagtacat catctctgag gagtcagtat ttcttgtgct gcagcatgcg   1380

gaaggtggca aactgtggtc atatatcagt aaatttctaa acagaagtcc tgaagaaagc   1440

tttgacatca aggaagtgaa aaaacctaca cttgcaaaag ttcacctgca gcagccaact   1500

tctagtcctc aggacagcag tagctttgaa tccagaggaa gtgatggtgg aagcatgctt   1560

aaagctctgc ctttgaagag tagtcttact ccaagttctc aagatgacag caaccaggaa   1620

gatgatggcc aagatagctc tccaaagtgg ccagattctg gttcaagttc agaagaagaa   1680

tgtactacta gttatttaac attatgcaat gaatatgggc aagaaaagat tgaaccaggg   1740

tctttgaatg aggagccctt catgaagact gaagggaatg gtgttgatac aaaagctatt   1800

aaaagcttcc cagcacacct tgctgctgac agtgacagcc ccagcacaca gctgagagct   1860

cacgagctga agttcttccc caacgatgac ccagaagcag ttagttctcc aagaacatca   1920

gattccctca gtagatcaaa aaatagcccc atggaattct ttaggataga cagtaaggat   1980

agcgcaagtg aactcctggg acttgacttt ggagaaaaat tgtatagtct aaaatcagaa   2040

cctttgaaac cattctttac tcttccagat ggagacagtg cttctaggag ttttaatact   2100

agtgaaagca aggtagagtt taaagctcag gacaccatta gcaggggctc agatgactca   2160

gtgccagtta tttcatttaa agatgctgct tttgatgatg tcagtggtac tgatgaagga   2220

agacctgatc ttcttgtaaa tttacctggt gaattggagt caacaagaga agctgcagca   2280

atgggaccta ctaagtttac acaaactaat atagggataa tagaaaataa actcttggaa   2340

gcccctgatg ttttatgcct caggcttagt actgaacaat gccaagcaca tgaggagaaa   2400

ggcatagagg aactgagtga tccctctggg cccaaatcct atagtataac agagaaacac   2460

tatgcacagg aggatcccag gatgttattt gtagcagctg ttgatcatag tagttcagga   2520

gatatgtctt tgttacccag ctcagatcct aagtttcaag gacttggagt ggttgagtca   2580

gcagtaactg caaacaacac agaagaaagc ttattccgta tttgtagtcc actctcaggt   2640

gctaatgaat atattgcaag cacagacact ttaaaaacag aagaagtatt gctgtttaca   2700

gatcagactg atgatttggc taaagaggaa ccaacttctt tattccagag agactctgag   2760

actaagggtg aaagtggttt agtgctagaa ggagacaagg aaatacatca gatttttgag   2820

gaccttgata aaaaattagc actagcctcc aggttttaca tcccagaggg ctgcattcaa   2880

agatgggcag ctgaaatggt ggtagccctt gatgctttac atagagaggg aattgtgtgc   2940

cgcgatttga acccaaacaa catcttattg aatgatagag gacacattca gctaacgtat   3000

tttagcaggt ggagtgaggt tgaagattcc tgtgacagcg atgccataga gagaatgtac   3060

tgtgccccag aggttggagc aatcactgaa gaaactgaag cctgtgattg gtggagtttg   3120

ggtgctgtcc tctttgaact tctcactggc aagactctgg ttgaatgcca tccagcagga   3180

ataaatactc acactacttt gaacatgcca gaatgtgtct ctgaagaggc tcgctcactc   3240

attcaacagc tcttgcagtt caatcctctg gaacgacttg gtgctggagt tgctggtgtt   3300

gaagatatca aatctcatcc attttttacc cctgtggatt gggcagaact gatgagatga   3360

acgtaatgca gggttatctt cacacattct gatcttctct gtgacaggca tctccagcac   3420

tgaggcacct ctgactcaca gttacttatg gagcaccaaa gcatttggat aaagaccgtt   3480

ataggaaatg ggggggaaat ggctaaaaga gaacaattcg tttacaatta caagatatta   3540

gctaattgtg ccaggggctg ttatatacat atatacacaa ccaaggtgtg atctgaattt   3600

aatccacatt tggtgttgca gatgagttgt aaagccaact gaaagagttc cttcaagaag   3660

ttcctctgat aggaagctag aagtgtagaa tgaagtttta cttgacagaa ggacctttac   3720

atggcagcta acagtgcttt ttgctgacca ggattggttt atatgattaa attaatattt   3780

gcttaataat acactaaaag tatatgaaca atgtcatcaa tgaaacttaa aagcgagaaa   3840

aaagaatata cacataattt ctgacggaaa acctgtaccc tgatgctgta taatgtatgt   3900

tgaatgtggt cccagattat ttctgtaaga agacactcca tgttgtcagc tttgtactct   3960

ttgttgatac tgcttattta gagaagggtt catataaaca ctcactctgt gtcttcaaca   4020

gcatctttct ttccccatct ttctattttc tgcaccctct gcttgttccc tcatattctg   4080

ttcttccgac tcctgctaac acacatgcaa caaaaaaggg aagggagtgc ttatttccct   4140

ttgtgtaagg actaagaaat catgatatca aataaacatg gtgaaacatt agatctcttc   4200

ttcatttaat aaccctcccc cctttttttc cttgaagaaa tgcgtctgtt cctttccttg   4260

tgaaatatta tcagtttcta ccattgcttc tcatgcttga ctttgtttta ctttttggct   4320

tggtatacta agaagcaaag gatctcatct aaatggaatt gaatggcagt cctagtttgt   4380

tacttatggt gatgagattt tcagatttga actaatctat ttgacgtgat ttagaaagaa   4440

tgtaagtatt cacacatctc caaacatttg tatttgttac ttctttttgt tgctaaggta   4500

gctcctgtag ttatgcattg ttgcaaaaat ttacaaatgt tttaaaagtg ttaacatctg   4560

ttttttttta aacgttagcc aaagaagaag tcactatttc caagttagaa accaccagaa   4620

ataattgaaa tttttgatat gttctaatct tctttgcatt tttgagatct gtgtgagagc   4680

ccaaccccac tccaggagca tctgtacagc ttccatctgc catcgaccag gtcctctcat   4740

caaattaaat ggaacagaaa atgctctagt gaaacaaagg aaatgtgcaa gcatttttcc   4800

tttttctatt attctatttc cctttttcct ttttggcccc cttataatcc aaaccccagc   4860

tgaaaggctg caacaacacc aggttgggga gcaggtcacc aggatcatag ttcagtcaaa   4920

atgacatcac tccctggaac tagatttcaa ctcactagtc ccctggcctc ataacaggaa   4980

cttatgcagg tgagacacaa gaatgacttc ctgtgtagga ctagtaggaa atctgcaagt   5040

acttagagct ggccattaca gaacttcctt ccagaagtgc cctgtgacat gaaagtagga   5100

cttcacaact aaggtgaaga tccctgccct accacatgat ttgagtctct tggattcaaa   5160

ggacattaat gtcaacagat ggttgccatg tcagtctgtt gacacaattc cattgcttca   5220

gtttctcccc ttttctctct atatgtttgg ttggagcttg tgcctaatgt aaatacatca   5280

ttcataatta gaatggacat taattatttt agtaataaac acaggataaa tagctttggg   5340

gtgatgaacc agagtctgtt tttattttat ggtgtgtaca tattttaagc tgtacttctg   5400

tgaatggtac tgatttttgt ggttgttttt tttttatatt ttgtttgttt aagcagaaga   5460

gtggaatatg gggtcaaaat cataaaagaa gttgccatg                          5499


<210>  7108
<211>  1066
<212>  PRT
<213>  Homosapiens

<400>  7108

Met Thr Ser Tyr Arg Glu Arg Ser Ala Asp Leu Ala Arg Phe Tyr Thr 
1               5                   10                  15      


Val Thr Glu Pro Gln Arg His Pro Arg Gly Tyr Thr Val Tyr Lys Val 
            20                  25                  30          


Thr Ala Arg Val Val Ser Arg Arg Asn Pro Glu Asp Val Gln Glu Ile 
        35                  40                  45              


Ile Val Trp Lys Arg Tyr Ser Asp Phe Lys Lys Leu His Lys Glu Leu 
    50                  55                  60                  


Trp Gln Ile His Lys Asn Leu Phe Arg His Ser Glu Leu Phe Pro Pro 
65                  70                  75                  80  


Phe Ala Lys Gly Ile Val Phe Gly Arg Phe Asp Glu Thr Val Ile Glu 
                85                  90                  95      


Glu Arg Arg Gln Cys Ala Glu Asp Leu Leu Gln Phe Ser Ala Asn Ile 
            100                 105                 110         


Pro Ala Leu Tyr Asn Ser Lys Gln Leu Glu Asp Phe Phe Lys Gly Gly 
        115                 120                 125             


Ile Ile Asn Asp Ser Ser Glu Leu Ile Gly Pro Ala Glu Ala His Ser 
    130                 135                 140                 


Asp Ser Leu Ile Asp Thr Phe Pro Glu Cys Ser Thr Glu Gly Phe Ser 
145                 150                 155                 160 


Ser Asp Ser Asp Leu Val Ser Leu Thr Val Asp Val Asp Ser Leu Ala 
                165                 170                 175     


Glu Leu Asp Asp Gly Met Ala Ser Asn Gln Asn Ser Pro Ile Arg Thr 
            180                 185                 190         


Phe Gly Leu Asn Leu Ser Ser Asp Ser Ser Ala Leu Gly Ala Val Ala 
        195                 200                 205             


Ser Asp Ser Glu Gln Ser Lys Thr Glu Glu Glu Arg Glu Ser Arg Ser 
    210                 215                 220                 


Leu Phe Pro Gly Ser Leu Lys Pro Lys Leu Gly Lys Arg Asp Tyr Leu 
225                 230                 235                 240 


Glu Lys Ala Gly Glu Leu Ile Lys Leu Ala Leu Lys Lys Glu Glu Glu 
                245                 250                 255     


Asp Asp Tyr Glu Ala Ala Ser Asp Phe Tyr Arg Lys Gly Val Asp Leu 
            260                 265                 270         


Leu Leu Glu Gly Val Gln Gly Glu Ser Ser Pro Thr Arg Arg Glu Ala 
        275                 280                 285             


Val Lys Arg Arg Thr Ala Glu Tyr Leu Met Arg Ala Glu Ser Ile Ser 
    290                 295                 300                 


Ser Leu Tyr Gly Lys Pro Gln Leu Asp Asp Val Ser Gln Pro Pro Gly 
305                 310                 315                 320 


Ser Leu Ser Ser Arg Pro Leu Trp Asn Leu Arg Ser Pro Ala Glu Glu 
                325                 330                 335     


Leu Lys Ala Phe Arg Val Leu Gly Val Ile Asp Lys Val Leu Leu Val 
            340                 345                 350         


Met Asp Thr Arg Thr Glu Gln Thr Phe Ile Leu Lys Gly Leu Arg Lys 
        355                 360                 365             


Ser Ser Glu Tyr Ser Arg Asn Arg Lys Thr Ile Ile Pro Arg Cys Val 
    370                 375                 380                 


Pro Asn Met Val Cys Leu His Lys Tyr Ile Ile Ser Glu Glu Ser Val 
385                 390                 395                 400 


Phe Leu Val Leu Gln His Ala Glu Gly Gly Lys Leu Trp Ser Tyr Ile 
                405                 410                 415     


Ser Lys Phe Leu Asn Arg Ser Pro Glu Glu Ser Phe Asp Ile Lys Glu 
            420                 425                 430         


Val Lys Lys Pro Thr Leu Ala Lys Val His Leu Gln Gln Pro Thr Ser 
        435                 440                 445             


Ser Pro Gln Asp Ser Ser Ser Phe Glu Ser Arg Gly Ser Asp Gly Gly 
    450                 455                 460                 


Ser Met Leu Lys Ala Leu Pro Leu Lys Ser Ser Leu Thr Pro Ser Ser 
465                 470                 475                 480 


Gln Asp Asp Ser Asn Gln Glu Asp Asp Gly Gln Asp Ser Ser Pro Lys 
                485                 490                 495     


Trp Pro Asp Ser Gly Ser Ser Ser Glu Glu Glu Cys Thr Thr Ser Tyr 
            500                 505                 510         


Leu Thr Leu Cys Asn Glu Tyr Gly Gln Glu Lys Ile Glu Pro Gly Ser 
        515                 520                 525             


Leu Asn Glu Glu Pro Phe Met Lys Thr Glu Gly Asn Gly Val Asp Thr 
    530                 535                 540                 


Lys Ala Ile Lys Ser Phe Pro Ala His Leu Ala Ala Asp Ser Asp Ser 
545                 550                 555                 560 


Pro Ser Thr Gln Leu Arg Ala His Glu Leu Lys Phe Phe Pro Asn Asp 
                565                 570                 575     


Asp Pro Glu Ala Val Ser Ser Pro Arg Thr Ser Asp Ser Leu Ser Arg 
            580                 585                 590         


Ser Lys Asn Ser Pro Met Glu Phe Phe Arg Ile Asp Ser Lys Asp Ser 
        595                 600                 605             


Ala Ser Glu Leu Leu Gly Leu Asp Phe Gly Glu Lys Leu Tyr Ser Leu 
    610                 615                 620                 


Lys Ser Glu Pro Leu Lys Pro Phe Phe Thr Leu Pro Asp Gly Asp Ser 
625                 630                 635                 640 


Ala Ser Arg Ser Phe Asn Thr Ser Glu Ser Lys Val Glu Phe Lys Ala 
                645                 650                 655     


Gln Asp Thr Ile Ser Arg Gly Ser Asp Asp Ser Val Pro Val Ile Ser 
            660                 665                 670         


Phe Lys Asp Ala Ala Phe Asp Asp Val Ser Gly Thr Asp Glu Gly Arg 
        675                 680                 685             


Pro Asp Leu Leu Val Asn Leu Pro Gly Glu Leu Glu Ser Thr Arg Glu 
    690                 695                 700                 


Ala Ala Ala Met Gly Pro Thr Lys Phe Thr Gln Thr Asn Ile Gly Ile 
705                 710                 715                 720 


Ile Glu Asn Lys Leu Leu Glu Ala Pro Asp Val Leu Cys Leu Arg Leu 
                725                 730                 735     


Ser Thr Glu Gln Cys Gln Ala His Glu Glu Lys Gly Ile Glu Glu Leu 
            740                 745                 750         


Ser Asp Pro Ser Gly Pro Lys Ser Tyr Ser Ile Thr Glu Lys His Tyr 
        755                 760                 765             


Ala Gln Glu Asp Pro Arg Met Leu Phe Val Ala Ala Val Asp His Ser 
    770                 775                 780                 


Ser Ser Gly Asp Met Ser Leu Leu Pro Ser Ser Asp Pro Lys Phe Gln 
785                 790                 795                 800 


Gly Leu Gly Val Val Glu Ser Ala Val Thr Ala Asn Asn Thr Glu Glu 
                805                 810                 815     


Ser Leu Phe Arg Ile Cys Ser Pro Leu Ser Gly Ala Asn Glu Tyr Ile 
            820                 825                 830         


Ala Ser Thr Asp Thr Leu Lys Thr Glu Glu Val Leu Leu Phe Thr Asp 
        835                 840                 845             


Gln Thr Asp Asp Leu Ala Lys Glu Glu Pro Thr Ser Leu Phe Gln Arg 
    850                 855                 860                 


Asp Ser Glu Thr Lys Gly Glu Ser Gly Leu Val Leu Glu Gly Asp Lys 
865                 870                 875                 880 


Glu Ile His Gln Ile Phe Glu Asp Leu Asp Lys Lys Leu Ala Leu Ala 
                885                 890                 895     


Ser Arg Phe Tyr Ile Pro Glu Gly Cys Ile Gln Arg Trp Ala Ala Glu 
            900                 905                 910         


Met Val Val Ala Leu Asp Ala Leu His Arg Glu Gly Ile Val Cys Arg 
        915                 920                 925             


Asp Leu Asn Pro Asn Asn Ile Leu Leu Asn Asp Arg Gly His Ile Gln 
    930                 935                 940                 


Leu Thr Tyr Phe Ser Arg Trp Ser Glu Val Glu Asp Ser Cys Asp Ser 
945                 950                 955                 960 


Asp Ala Ile Glu Arg Met Tyr Cys Ala Pro Glu Val Gly Ala Ile Thr 
                965                 970                 975     


Glu Glu Thr Glu Ala Cys Asp Trp Trp Ser Leu Gly Ala Val Leu Phe 
            980                 985                 990         


Glu Leu Leu Thr Gly Lys Thr Leu  Val Glu Cys His Pro  Ala Gly Ile 
        995                 1000                 1005             


Asn Thr  His Thr Thr Leu Asn  Met Pro Glu Cys Val  Ser Glu Glu 
    1010                 1015                 1020             


Ala Arg  Ser Leu Ile Gln Gln  Leu Leu Gln Phe Asn  Pro Leu Glu 
    1025                 1030                 1035             


Arg Leu  Gly Ala Gly Val Ala  Gly Val Glu Asp Ile  Lys Ser His 
    1040                 1045                 1050             


Pro Phe  Phe Thr Pro Val Asp  Trp Ala Glu Leu Met  Arg 
    1055                 1060                 1065     


<210>  7109
<211>  4138
<212>  DNA
<213>  Homosapiens

<400>  7109
agctgaggcg ccgccgtgga gccgccttgg agccaccgcc ccctcgccgc ttcgccgctg     60

cgttggggaa cctggaccgc ggcggcgccg ggtttccctc atgatcccgg gcgggtggcg    120

gcggcggcag aggcggcggg aggatgacct cttaccggga gcggagtgcc gacctggccc    180

gtttctacac tgtcaccgag ccccagcgac acccgagggg ctacacagta tataaggtca    240

ccgcccggat aattgtatgg aagagataca gtgattttaa gaaactacac aaagaactat    300

ggcaaattca caaaaactta ttccgacatt cagagttgtt tcctccattt gctaaaggaa    360

tagtgtttgg gcgatttgat gaaactgtta tcgaagagag aagacaatgt gctgaagacc    420

tgctacagtt ctctgccaat attcctgctc tttacaatag taaacagctt gaagactttt    480

tcaagggtgg aataattaat gatagttctg aattaattgg tcctgctgaa gctcactcag    540

attccctcat tgataccttt cctgagtgta gtacggaagg cttctccagt gacagtgatc    600

tggtatctct tactgttgat gtggattctc ttgctgagtt agatgatgga atggcttcca    660

atcaaaattc tcccattaga acttttggtc tcaatctttc ttcggattct tcagcactag    720

gggctgttgc ttctgacagt gaacagagca aaacagaaga agaacgggaa agtcgtagcc    780

tctttcctgg cagtttaaag ccgaagcttg gcaagagaga ttatttggag aaagcaggag    840

aattaataaa gctggcttta aaaaaggaag aagaagacga ctatgaagct gcttctgatt    900

tttataggaa gggagttgat ttactcctag aaggtgttca aggagagtca agccctaccc    960

gtcgagaagc tgtgaagaga agaacagccg agtacctcat gcgggcagaa agtatctcta   1020

gtctttatgg gaaacctcag cttgatgatg tatctcagcc tccaggatca ctaagttcaa   1080

ggcccctttg gaacctaagg agccctgccg aggagctgaa ggccttcaga gtccttgggg   1140

tgattgacaa ggttttactt gtaatggaca caaggacaga acagactttc attttaaaag   1200

gtctaaggaa aagcagtgaa tacagcagga acagaaagac catcatcccc cgctgtgtgc   1260

ccaacatggt gtgtctgcat aagtacatca tctctgagga gtcagtattt cttgtgctgc   1320

agcatgcgga aggtggcaaa ctgtggtcat atatcagtaa atttctaaac agaagtcctg   1380

aagaaagctt tgacatcaag gaagtgaaaa aacctacact tgcaaaagtt cacctgcagc   1440

agccaacttc tagtcctcag gacagcagta gctttgaatc cagaggaagt gatggtggaa   1500

gcatgcttaa agctctgcct ttgaagagta gtcttactcc aagttctcaa gatgacagca   1560

accaggaaga tgatggccaa gatagctctc caaagtggcc agattctggt tcaagttcag   1620

aagaagaatg tactactagt tatttaacat tatgcaatga atatgggcaa gaaaagattg   1680

aaccagggtc tttgaatgag gagcccttca tgaagactga agggaatggt gttgatacaa   1740

aagctattaa aagcttccca gcacaccttg ctgctgacag tgacagcccc agcacacagc   1800

tgagagctca cgagctgaag ttcttcccca acgatgaccc agaagcagtt agttctccaa   1860

gaacatcaga ttccctcagt agatcaaaaa atagccccat ggaattcttt aggatagaca   1920

gtaaggatag cgcaagtgaa ctcctgggac ttgactttgg agaaaaattg tatagtctaa   1980

aatcagaacc tttgaaacca ttctttactc ttccagatgg agacagtgct tctaggagtt   2040

ttaatactag tgaaagcaag gtagagttta aagctcagga caccattagc aggggctcag   2100

atgactcagt gccagttatt tcatttaaag atgctgcttt tgatgatgtc agtggtactg   2160

atgaaggaag acctgatctt cttgtaaatt tacctggtga attggagtca acaagagaag   2220

ctgcagcaat gggacctact aagtttacac aaactaatat agggataata gaaaataaac   2280

tcttggaagc ccctgatgtt ttatgcctca ggcttagtac tgaacaatgc caagcacatg   2340

aggagaaagg catagaggaa ctgagtgatc cctctgggcc caaatcctat agtataacag   2400

agaaacacta tgcacaggag gatcccagga tgttatttgt agcagctgtt gatcatagta   2460

gttcaggaga tatgtctttg ttacccagct cagatcctaa gtttcaagga cttggagtgg   2520

ttgagtcagc agtaactgca aacaacacag aagaaagctt attccgtatt tgtagtccac   2580

tctcaggtgc taatgaatat attgcaagca cagacacttt aaaaacagaa gaagtattgc   2640

tgtttacaga tcagactgat gatttggcta aagaggaacc aacttcttta ttccagagag   2700

actctgagac taagggtgaa agtggtttag tgctagaagg agacaaggaa atacatcaga   2760

tttttgagga ccttgataaa aaattagcac tagcctccag gttttacatc ccagagggct   2820

gcattcaaag atgggcagct gaaatggtgg tagcccttga tgctttacat agagagggaa   2880

ttgtgtgccg cgatttgaac ccaaacaaca tcttattgaa tgatagagga cacattcagc   2940

taacgtattt tagcaggtgg agtgaggttg aagattcctg tgacagcgat gccatagaga   3000

gaatgtactg tgccccagag gttggagcaa tcactgaaga aactgaagcc tgtgattggt   3060

ggagtttggg tgctgtcctc tttgaacttc tcactggcaa gactctggtt gaatgccatc   3120

cagcaggaat aaatactcac actactttga acatgccaga atgtgtctct gaagaggctc   3180

gctcactcat tcaacagctc ttgcagttca atcctctgga acgacttggt gctggagttg   3240

ctggtgttga agatatcaaa tctcatccat tttttacccc tgtggattgg gcagaactga   3300

tgagatgaac gtaatgcagg gttatcttca cacattctga tcttctctgt gacaggcatc   3360

tccagcactg aggcacctct gactcacagt tacttatgga gcaccaaagc atttggataa   3420

agaccgttat aggaaatggg ggggaaatgg ctaaaagaga acaattcgtt tacaattaca   3480

agatattagc taattgtgcc aggggctgtt atatacatat atacacaacc aaggtgtgat   3540

ctgaatttaa tccacatttg gtgttgcaga tgagttgtaa agccaactga aagagttcct   3600

tcaagaagtt cctctgatag gaagctagaa gtgtagaatg aagttttact tgacagaagg   3660

acctttacat ggcagctaac agtgcttttt gctgaccagg attggtttat atgattaaat   3720

taatatttgc ttaataatac actaaaagta tatgaacaat gtcatcaatg aaacttaaaa   3780

gcgagaaaaa agaatataca cataatttct gacggaaaac ctgtaccctg atgctgtata   3840

atgtatgttg aatgtggtcc cagattattt ctgtaagaag acactccatg ttgtcagctt   3900

tgtactcttt gttgatactg cttatttaga gaagggttca tataaacact cactctgtgt   3960

cttcaacagc atctttcttt ccccatcttt ctattttctg caccctctgc ttgttccctc   4020

atattctgtt cttccgactc ctgctaacac acatgcaaca aaaaagggaa gggagtgctt   4080

atttcccttt gtgtaaggac taagaaatca tgatatcaaa taaacatggt gaaacatt     4138


<210>  7110
<211>  1054
<212>  PRT
<213>  Homosapiens

<400>  7110

Met Thr Ser Tyr Arg Glu Arg Ser Ala Asp Leu Ala Arg Phe Tyr Thr 
1               5                   10                  15      


Val Thr Glu Pro Gln Arg His Pro Arg Gly Tyr Thr Val Tyr Lys Val 
            20                  25                  30          


Thr Ala Arg Ile Ile Val Trp Lys Arg Tyr Ser Asp Phe Lys Lys Leu 
        35                  40                  45              


His Lys Glu Leu Trp Gln Ile His Lys Asn Leu Phe Arg His Ser Glu 
    50                  55                  60                  


Leu Phe Pro Pro Phe Ala Lys Gly Ile Val Phe Gly Arg Phe Asp Glu 
65                  70                  75                  80  


Thr Val Ile Glu Glu Arg Arg Gln Cys Ala Glu Asp Leu Leu Gln Phe 
                85                  90                  95      


Ser Ala Asn Ile Pro Ala Leu Tyr Asn Ser Lys Gln Leu Glu Asp Phe 
            100                 105                 110         


Phe Lys Gly Gly Ile Ile Asn Asp Ser Ser Glu Leu Ile Gly Pro Ala 
        115                 120                 125             


Glu Ala His Ser Asp Ser Leu Ile Asp Thr Phe Pro Glu Cys Ser Thr 
    130                 135                 140                 


Glu Gly Phe Ser Ser Asp Ser Asp Leu Val Ser Leu Thr Val Asp Val 
145                 150                 155                 160 


Asp Ser Leu Ala Glu Leu Asp Asp Gly Met Ala Ser Asn Gln Asn Ser 
                165                 170                 175     


Pro Ile Arg Thr Phe Gly Leu Asn Leu Ser Ser Asp Ser Ser Ala Leu 
            180                 185                 190         


Gly Ala Val Ala Ser Asp Ser Glu Gln Ser Lys Thr Glu Glu Glu Arg 
        195                 200                 205             


Glu Ser Arg Ser Leu Phe Pro Gly Ser Leu Lys Pro Lys Leu Gly Lys 
    210                 215                 220                 


Arg Asp Tyr Leu Glu Lys Ala Gly Glu Leu Ile Lys Leu Ala Leu Lys 
225                 230                 235                 240 


Lys Glu Glu Glu Asp Asp Tyr Glu Ala Ala Ser Asp Phe Tyr Arg Lys 
                245                 250                 255     


Gly Val Asp Leu Leu Leu Glu Gly Val Gln Gly Glu Ser Ser Pro Thr 
            260                 265                 270         


Arg Arg Glu Ala Val Lys Arg Arg Thr Ala Glu Tyr Leu Met Arg Ala 
        275                 280                 285             


Glu Ser Ile Ser Ser Leu Tyr Gly Lys Pro Gln Leu Asp Asp Val Ser 
    290                 295                 300                 


Gln Pro Pro Gly Ser Leu Ser Ser Arg Pro Leu Trp Asn Leu Arg Ser 
305                 310                 315                 320 


Pro Ala Glu Glu Leu Lys Ala Phe Arg Val Leu Gly Val Ile Asp Lys 
                325                 330                 335     


Val Leu Leu Val Met Asp Thr Arg Thr Glu Gln Thr Phe Ile Leu Lys 
            340                 345                 350         


Gly Leu Arg Lys Ser Ser Glu Tyr Ser Arg Asn Arg Lys Thr Ile Ile 
        355                 360                 365             


Pro Arg Cys Val Pro Asn Met Val Cys Leu His Lys Tyr Ile Ile Ser 
    370                 375                 380                 


Glu Glu Ser Val Phe Leu Val Leu Gln His Ala Glu Gly Gly Lys Leu 
385                 390                 395                 400 


Trp Ser Tyr Ile Ser Lys Phe Leu Asn Arg Ser Pro Glu Glu Ser Phe 
                405                 410                 415     


Asp Ile Lys Glu Val Lys Lys Pro Thr Leu Ala Lys Val His Leu Gln 
            420                 425                 430         


Gln Pro Thr Ser Ser Pro Gln Asp Ser Ser Ser Phe Glu Ser Arg Gly 
        435                 440                 445             


Ser Asp Gly Gly Ser Met Leu Lys Ala Leu Pro Leu Lys Ser Ser Leu 
    450                 455                 460                 


Thr Pro Ser Ser Gln Asp Asp Ser Asn Gln Glu Asp Asp Gly Gln Asp 
465                 470                 475                 480 


Ser Ser Pro Lys Trp Pro Asp Ser Gly Ser Ser Ser Glu Glu Glu Cys 
                485                 490                 495     


Thr Thr Ser Tyr Leu Thr Leu Cys Asn Glu Tyr Gly Gln Glu Lys Ile 
            500                 505                 510         


Glu Pro Gly Ser Leu Asn Glu Glu Pro Phe Met Lys Thr Glu Gly Asn 
        515                 520                 525             


Gly Val Asp Thr Lys Ala Ile Lys Ser Phe Pro Ala His Leu Ala Ala 
    530                 535                 540                 


Asp Ser Asp Ser Pro Ser Thr Gln Leu Arg Ala His Glu Leu Lys Phe 
545                 550                 555                 560 


Phe Pro Asn Asp Asp Pro Glu Ala Val Ser Ser Pro Arg Thr Ser Asp 
                565                 570                 575     


Ser Leu Ser Arg Ser Lys Asn Ser Pro Met Glu Phe Phe Arg Ile Asp 
            580                 585                 590         


Ser Lys Asp Ser Ala Ser Glu Leu Leu Gly Leu Asp Phe Gly Glu Lys 
        595                 600                 605             


Leu Tyr Ser Leu Lys Ser Glu Pro Leu Lys Pro Phe Phe Thr Leu Pro 
    610                 615                 620                 


Asp Gly Asp Ser Ala Ser Arg Ser Phe Asn Thr Ser Glu Ser Lys Val 
625                 630                 635                 640 


Glu Phe Lys Ala Gln Asp Thr Ile Ser Arg Gly Ser Asp Asp Ser Val 
                645                 650                 655     


Pro Val Ile Ser Phe Lys Asp Ala Ala Phe Asp Asp Val Ser Gly Thr 
            660                 665                 670         


Asp Glu Gly Arg Pro Asp Leu Leu Val Asn Leu Pro Gly Glu Leu Glu 
        675                 680                 685             


Ser Thr Arg Glu Ala Ala Ala Met Gly Pro Thr Lys Phe Thr Gln Thr 
    690                 695                 700                 


Asn Ile Gly Ile Ile Glu Asn Lys Leu Leu Glu Ala Pro Asp Val Leu 
705                 710                 715                 720 


Cys Leu Arg Leu Ser Thr Glu Gln Cys Gln Ala His Glu Glu Lys Gly 
                725                 730                 735     


Ile Glu Glu Leu Ser Asp Pro Ser Gly Pro Lys Ser Tyr Ser Ile Thr 
            740                 745                 750         


Glu Lys His Tyr Ala Gln Glu Asp Pro Arg Met Leu Phe Val Ala Ala 
        755                 760                 765             


Val Asp His Ser Ser Ser Gly Asp Met Ser Leu Leu Pro Ser Ser Asp 
    770                 775                 780                 


Pro Lys Phe Gln Gly Leu Gly Val Val Glu Ser Ala Val Thr Ala Asn 
785                 790                 795                 800 


Asn Thr Glu Glu Ser Leu Phe Arg Ile Cys Ser Pro Leu Ser Gly Ala 
                805                 810                 815     


Asn Glu Tyr Ile Ala Ser Thr Asp Thr Leu Lys Thr Glu Glu Val Leu 
            820                 825                 830         


Leu Phe Thr Asp Gln Thr Asp Asp Leu Ala Lys Glu Glu Pro Thr Ser 
        835                 840                 845             


Leu Phe Gln Arg Asp Ser Glu Thr Lys Gly Glu Ser Gly Leu Val Leu 
    850                 855                 860                 


Glu Gly Asp Lys Glu Ile His Gln Ile Phe Glu Asp Leu Asp Lys Lys 
865                 870                 875                 880 


Leu Ala Leu Ala Ser Arg Phe Tyr Ile Pro Glu Gly Cys Ile Gln Arg 
                885                 890                 895     


Trp Ala Ala Glu Met Val Val Ala Leu Asp Ala Leu His Arg Glu Gly 
            900                 905                 910         


Ile Val Cys Arg Asp Leu Asn Pro Asn Asn Ile Leu Leu Asn Asp Arg 
        915                 920                 925             


Gly His Ile Gln Leu Thr Tyr Phe Ser Arg Trp Ser Glu Val Glu Asp 
    930                 935                 940                 


Ser Cys Asp Ser Asp Ala Ile Glu Arg Met Tyr Cys Ala Pro Glu Val 
945                 950                 955                 960 


Gly Ala Ile Thr Glu Glu Thr Glu Ala Cys Asp Trp Trp Ser Leu Gly 
                965                 970                 975     


Ala Val Leu Phe Glu Leu Leu Thr Gly Lys Thr Leu Val Glu Cys His 
            980                 985                 990         


Pro Ala Gly Ile Asn Thr His Thr  Thr Leu Asn Met Pro  Glu Cys Val 
        995                 1000                 1005             


Ser Glu  Glu Ala Arg Ser Leu  Ile Gln Gln Leu Leu  Gln Phe Asn 
    1010                 1015                 1020             


Pro Leu  Glu Arg Leu Gly Ala  Gly Val Ala Gly Val  Glu Asp Ile 
    1025                 1030                 1035             


Lys Ser  His Pro Phe Phe Thr  Pro Val Asp Trp Ala  Glu Leu Met 
    1040                 1045                 1050             


Arg 
    


<210>  7111
<211>  5447
<212>  DNA
<213>  Homosapiens

<400>  7111
agctgaggcg ccgccgtgga gccgccttgg agccaccgcc ccctcgccgc ttcgccgctg     60

cgttggggaa cctggaccgc ggcggcgccg ggtttccctc atgatcccgg gcgggtggcg    120

gcggcggcag aggcggcggg aggatgacct cttaccggga gcggagtgcc gacctggccc    180

gtttctacac tgtcaccgag ccccagcgac acccgagggg ctacacagta tataaggtca    240

ccgcccggat aattgtatgg aagagataca gtgattttaa gaaactacac aaagaactat    300

ggcaaattca caaaaactta ttccgacatt cagagttgtt tcctccattt gctaaaggaa    360

tagtgtttgg gcgatttgat gaaactgtta tcgaagagag aagacaatgt gctgaagacc    420

tgctacagtt ctctgccaat attcctgctc tttacaatag taaacagctt gaagactttt    480

tcaagggtgg aataattaat gatagttctg aattaattgg tcctgctgaa gctcactcag    540

attccctcat tgataccttt cctgagtgta gtacggaagg cttctccagt gacagtgatc    600

tggtatctct tactgttgat gtggattctc ttgctgagtt agatgatgga atggcttcca    660

atcaaaattc tcccattaga acttttggtc tcaatctttc ttcggattct tcagcactag    720

gggctgttgc ttctgacagt gaacagagca aaacagaaga agaacgggaa agtcgtagcc    780

tctttcctgg cagtttaaag ccgaagcttg gcaagagaga ttatttggag aaagcaggag    840

aattaataaa gctggcttta aaaaaggaag aagaagacga ctatgaagct gcttctgatt    900

tttataggaa gggagttgat ttactcctag aaggtgttca aggagagtca agccctaccc    960

gtcgagaagc tgtgaagaga agaacagccg agtacctcat gcgggcagaa agtatctcta   1020

gtctttatgg gaaacctcag cttgatgatg tatctcagcc tccaggatca ctaagttcaa   1080

ggcccctttg gaacctaagg agccctgccg aggagctgaa ggccttcaga gtccttgggg   1140

tgattgacaa ggttttactt gtaatggaca caaggacaga acagactttc attttaaaag   1200

gtctaaggaa aagcagtgaa tacagcagga acagaaagac catcatcccc cgctgtgtgc   1260

ccaacatggt gtgtctgcat aagtacatca tctctgagga gtcagtattt cttgtgctgc   1320

agcatgcgga aggtggcaaa ctgtggtcat atatcagtaa atttctaaac agaagtcctg   1380

aagaaagctt tgacatcaag gaagtgaaaa aacctacact tgcaaaagtt cacctgcagc   1440

agccaacttc tagtcctcag gacagcagta gctttgaatc cagaggaagt gatggtggaa   1500

gcatgcttaa agctctgcct ttgaagagta gtcttactcc aagttctcaa gatgacagca   1560

accaggaaga tgatggccaa gatagctctc caaagtggcc agattctggt tcaagttcag   1620

aagaagaatg tactactagt tatttaacat tatgcaatga atatgggcaa gaaaagattg   1680

aaccagggtc tttgaatgag gagcccttca tgaagactga agggaatggt gttgatacaa   1740

aagctattaa aagcttccca gcacaccttg ctgctgacag tgacagcccc agcacacagc   1800

tgagagctca cgagctgaag ttcttcccca acgatgaccc agaagcagtt agttctccaa   1860

gaacatcaga ttccctcagt agatcaaaaa atagccccat ggaattcttt aggatagaca   1920

gtaaggatag cgcaagtgaa ctcctgggac ttgactttgg agaaaaattg tatagtctaa   1980

aatcagaacc tttgaaacca ttctttactc ttccagatgg agacagtgct tctaggagtt   2040

ttaatactag tgaaagcaag gtagagttta aagctcagga caccattagc aggggctcag   2100

atgactcagt gccagttatt tcatttaaag atgctgcttt tgatgatgtc agtggtactg   2160

atgaaggaag acctgatctt cttgtaaatt tacctggtga attggagtca acaagagaag   2220

ctgcagcaat gggacctact aagtttacac aaactaatat agggataata gaaaataaac   2280

tcttggaagc ccctgatgtt ttatgcctca ggcttagtac tgaacaatgc caagcacatg   2340

aggagaaagg catagaggaa ctgagtgatc cctctgggcc caaatcctat agtataacag   2400

agaaacacta tgcacaggag gatcccagga tgttatttgt agcagctgtt gatcatagta   2460

gttcaggaga tatgtctttg ttacccagct cagatcctaa gtttcaagga cttggagtgg   2520

ttgagtcagc agtaactgca aacaacacag aagaaagctt attccgtatt tgtagtccac   2580

tctcaggtgc taatgaatat attgcaagca cagacacttt aaaaacagaa gaagtattgc   2640

tgtttacaga tcagactgat gatttggcta aagaggaacc aacttcttta ttccagagag   2700

actctgagac taagggtgaa agtggtttag tgctagaagg agacaaggaa atacatcaga   2760

tttttgagga ccttgataaa aaattagcac tagcctccag gttttacatc ccagagggct   2820

gcattcaaag atgggcagct gaaatggtgg tagcccttga tgctttacat agagagggaa   2880

ttgtgtgccg cgatttgaac ccaaacaaca tcttattgaa tgatagagga cacattcagc   2940

taacgtattt tagcaggtgg agtgaggttg aagattcctg tgacagcgat gccatagaga   3000

gaatgtactg tgccccagag gttggagcaa tcactgaaga aactgaagcc tgtgattggt   3060

ggagtttggg tgctgtcctc tttgaacttc tcactggcaa gactctggtt gaatgccatc   3120

cagcaggaat aaatactcac actactttga acatgccaga atgtgtctct gaagaggctc   3180

gctcactcat tcaacagctc ttgcagttca atcctctgga acgacttggt gctggagttg   3240

ctggtgttga agatatcaaa tctcatccat tttttacccc tgtggattgg gcagaactga   3300

tgagatgaac gtaatgcagg gttatcttca cacattctga tcttctctgt gacaggcatc   3360

tccagcactg aggcacctct gactcacagt tacttatgga gcaccaaagc atttggataa   3420

agaccgttat aggaaatggg ggggaaatgg ctaaaagaga acaattcgtt tacaattaca   3480

agatattagc taattgtgcc aggggctgtt atatacatat atacacaacc aaggtgtgat   3540

ctgaatttaa tccacatttg gtgttgcaga tgagttgtaa agccaactga aagagttcct   3600

tcaagaagtt cctctgatag gaagctagaa gtgtagaatg aagttttact tgacagaagg   3660

acctttacat ggcagctaac agtgcttttt gctgaccagg attggtttat atgattaaat   3720

taatatttgc ttaataatac actaaaagta tatgaacaat gtcatcaatg aaacttaaaa   3780

gcgagaaaaa agaatataca cataatttct gacggaaaac ctgtaccctg atgctgtata   3840

atgtatgttg aatgtggtcc cagattattt ctgtaagaag acactccatg ttgtcagctt   3900

tgtactcttt gttgatactg cttatttaga gaagggttca tataaacact cactctgtgt   3960

cttcaacagc atctttcttt ccccatcttt ctattttctg caccctctgc ttgttccctc   4020

atattctgtt cttccgactc ctgctaacac acatgcaaca aaaaagggaa gggagtgctt   4080

atttcccttt gtgtaaggac taagaaatca tgatatcaaa taaacatggt gaaacattag   4140

atctcttctt catttaataa ccctcccccc tttttttcct tgaagaaatg cgtctgttcc   4200

tttccttgtg aaatattatc agtttctacc attgcttctc atgcttgact ttgttttact   4260

ttttggcttg gtatactaag aagcaaagga tctcatctaa atggaattga atggcagtcc   4320

tagtttgtta cttatggtga tgagattttc agatttgaac taatctattt gacgtgattt   4380

agaaagaatg taagtattca cacatctcca aacatttgta tttgttactt ctttttgttg   4440

ctaaggtagc tcctgtagtt atgcattgtt gcaaaaattt acaaatgttt taaaagtgtt   4500

aacatctgtt tttttttaaa cgttagccaa agaagaagtc actatttcca agttagaaac   4560

caccagaaat aattgaaatt tttgatatgt tctaatcttc tttgcatttt tgagatctgt   4620

gtgagagccc aaccccactc caggagcatc tgtacagctt ccatctgcca tcgaccaggt   4680

cctctcatca aattaaatgg aacagaaaat gctctagtga aacaaaggaa atgtgcaagc   4740

atttttcctt tttctattat tctatttccc tttttccttt ttggccccct tataatccaa   4800

accccagctg aaaggctgca acaacaccag gttggggagc aggtcaccag gatcatagtt   4860

cagtcaaaat gacatcactc cctggaacta gatttcaact cactagtccc ctggcctcat   4920

aacaggaact tatgcaggtg agacacaaga atgacttcct gtgtaggact agtaggaaat   4980

ctgcaagtac ttagagctgg ccattacaga acttccttcc agaagtgccc tgtgacatga   5040

aagtaggact tcacaactaa ggtgaagatc cctgccctac cacatgattt gagtctcttg   5100

gattcaaagg acattaatgt caacagatgg ttgccatgtc agtctgttga cacaattcca   5160

ttgcttcagt ttctcccctt ttctctctat atgtttggtt ggagcttgtg cctaatgtaa   5220

atacatcatt cataattaga atggacatta attattttag taataaacac aggataaata   5280

gctttggggt gatgaaccag agtctgtttt tattttatgg tgtgtacata ttttaagctg   5340

tacttctgtg aatggtactg atttttgtgg ttgttttttt tttatatttt gtttgtttaa   5400

gcagaagagt ggaatatggg gtcaaaatca taaaagaagt tgccatg                 5447


<210>  7112
<211>  1054
<212>  PRT
<213>  Homosapiens

<400>  7112

Met Thr Ser Tyr Arg Glu Arg Ser Ala Asp Leu Ala Arg Phe Tyr Thr 
1               5                   10                  15      


Val Thr Glu Pro Gln Arg His Pro Arg Gly Tyr Thr Val Tyr Lys Val 
            20                  25                  30          


Thr Ala Arg Ile Ile Val Trp Lys Arg Tyr Ser Asp Phe Lys Lys Leu 
        35                  40                  45              


His Lys Glu Leu Trp Gln Ile His Lys Asn Leu Phe Arg His Ser Glu 
    50                  55                  60                  


Leu Phe Pro Pro Phe Ala Lys Gly Ile Val Phe Gly Arg Phe Asp Glu 
65                  70                  75                  80  


Thr Val Ile Glu Glu Arg Arg Gln Cys Ala Glu Asp Leu Leu Gln Phe 
                85                  90                  95      


Ser Ala Asn Ile Pro Ala Leu Tyr Asn Ser Lys Gln Leu Glu Asp Phe 
            100                 105                 110         


Phe Lys Gly Gly Ile Ile Asn Asp Ser Ser Glu Leu Ile Gly Pro Ala 
        115                 120                 125             


Glu Ala His Ser Asp Ser Leu Ile Asp Thr Phe Pro Glu Cys Ser Thr 
    130                 135                 140                 


Glu Gly Phe Ser Ser Asp Ser Asp Leu Val Ser Leu Thr Val Asp Val 
145                 150                 155                 160 


Asp Ser Leu Ala Glu Leu Asp Asp Gly Met Ala Ser Asn Gln Asn Ser 
                165                 170                 175     


Pro Ile Arg Thr Phe Gly Leu Asn Leu Ser Ser Asp Ser Ser Ala Leu 
            180                 185                 190         


Gly Ala Val Ala Ser Asp Ser Glu Gln Ser Lys Thr Glu Glu Glu Arg 
        195                 200                 205             


Glu Ser Arg Ser Leu Phe Pro Gly Ser Leu Lys Pro Lys Leu Gly Lys 
    210                 215                 220                 


Arg Asp Tyr Leu Glu Lys Ala Gly Glu Leu Ile Lys Leu Ala Leu Lys 
225                 230                 235                 240 


Lys Glu Glu Glu Asp Asp Tyr Glu Ala Ala Ser Asp Phe Tyr Arg Lys 
                245                 250                 255     


Gly Val Asp Leu Leu Leu Glu Gly Val Gln Gly Glu Ser Ser Pro Thr 
            260                 265                 270         


Arg Arg Glu Ala Val Lys Arg Arg Thr Ala Glu Tyr Leu Met Arg Ala 
        275                 280                 285             


Glu Ser Ile Ser Ser Leu Tyr Gly Lys Pro Gln Leu Asp Asp Val Ser 
    290                 295                 300                 


Gln Pro Pro Gly Ser Leu Ser Ser Arg Pro Leu Trp Asn Leu Arg Ser 
305                 310                 315                 320 


Pro Ala Glu Glu Leu Lys Ala Phe Arg Val Leu Gly Val Ile Asp Lys 
                325                 330                 335     


Val Leu Leu Val Met Asp Thr Arg Thr Glu Gln Thr Phe Ile Leu Lys 
            340                 345                 350         


Gly Leu Arg Lys Ser Ser Glu Tyr Ser Arg Asn Arg Lys Thr Ile Ile 
        355                 360                 365             


Pro Arg Cys Val Pro Asn Met Val Cys Leu His Lys Tyr Ile Ile Ser 
    370                 375                 380                 


Glu Glu Ser Val Phe Leu Val Leu Gln His Ala Glu Gly Gly Lys Leu 
385                 390                 395                 400 


Trp Ser Tyr Ile Ser Lys Phe Leu Asn Arg Ser Pro Glu Glu Ser Phe 
                405                 410                 415     


Asp Ile Lys Glu Val Lys Lys Pro Thr Leu Ala Lys Val His Leu Gln 
            420                 425                 430         


Gln Pro Thr Ser Ser Pro Gln Asp Ser Ser Ser Phe Glu Ser Arg Gly 
        435                 440                 445             


Ser Asp Gly Gly Ser Met Leu Lys Ala Leu Pro Leu Lys Ser Ser Leu 
    450                 455                 460                 


Thr Pro Ser Ser Gln Asp Asp Ser Asn Gln Glu Asp Asp Gly Gln Asp 
465                 470                 475                 480 


Ser Ser Pro Lys Trp Pro Asp Ser Gly Ser Ser Ser Glu Glu Glu Cys 
                485                 490                 495     


Thr Thr Ser Tyr Leu Thr Leu Cys Asn Glu Tyr Gly Gln Glu Lys Ile 
            500                 505                 510         


Glu Pro Gly Ser Leu Asn Glu Glu Pro Phe Met Lys Thr Glu Gly Asn 
        515                 520                 525             


Gly Val Asp Thr Lys Ala Ile Lys Ser Phe Pro Ala His Leu Ala Ala 
    530                 535                 540                 


Asp Ser Asp Ser Pro Ser Thr Gln Leu Arg Ala His Glu Leu Lys Phe 
545                 550                 555                 560 


Phe Pro Asn Asp Asp Pro Glu Ala Val Ser Ser Pro Arg Thr Ser Asp 
                565                 570                 575     


Ser Leu Ser Arg Ser Lys Asn Ser Pro Met Glu Phe Phe Arg Ile Asp 
            580                 585                 590         


Ser Lys Asp Ser Ala Ser Glu Leu Leu Gly Leu Asp Phe Gly Glu Lys 
        595                 600                 605             


Leu Tyr Ser Leu Lys Ser Glu Pro Leu Lys Pro Phe Phe Thr Leu Pro 
    610                 615                 620                 


Asp Gly Asp Ser Ala Ser Arg Ser Phe Asn Thr Ser Glu Ser Lys Val 
625                 630                 635                 640 


Glu Phe Lys Ala Gln Asp Thr Ile Ser Arg Gly Ser Asp Asp Ser Val 
                645                 650                 655     


Pro Val Ile Ser Phe Lys Asp Ala Ala Phe Asp Asp Val Ser Gly Thr 
            660                 665                 670         


Asp Glu Gly Arg Pro Asp Leu Leu Val Asn Leu Pro Gly Glu Leu Glu 
        675                 680                 685             


Ser Thr Arg Glu Ala Ala Ala Met Gly Pro Thr Lys Phe Thr Gln Thr 
    690                 695                 700                 


Asn Ile Gly Ile Ile Glu Asn Lys Leu Leu Glu Ala Pro Asp Val Leu 
705                 710                 715                 720 


Cys Leu Arg Leu Ser Thr Glu Gln Cys Gln Ala His Glu Glu Lys Gly 
                725                 730                 735     


Ile Glu Glu Leu Ser Asp Pro Ser Gly Pro Lys Ser Tyr Ser Ile Thr 
            740                 745                 750         


Glu Lys His Tyr Ala Gln Glu Asp Pro Arg Met Leu Phe Val Ala Ala 
        755                 760                 765             


Val Asp His Ser Ser Ser Gly Asp Met Ser Leu Leu Pro Ser Ser Asp 
    770                 775                 780                 


Pro Lys Phe Gln Gly Leu Gly Val Val Glu Ser Ala Val Thr Ala Asn 
785                 790                 795                 800 


Asn Thr Glu Glu Ser Leu Phe Arg Ile Cys Ser Pro Leu Ser Gly Ala 
                805                 810                 815     


Asn Glu Tyr Ile Ala Ser Thr Asp Thr Leu Lys Thr Glu Glu Val Leu 
            820                 825                 830         


Leu Phe Thr Asp Gln Thr Asp Asp Leu Ala Lys Glu Glu Pro Thr Ser 
        835                 840                 845             


Leu Phe Gln Arg Asp Ser Glu Thr Lys Gly Glu Ser Gly Leu Val Leu 
    850                 855                 860                 


Glu Gly Asp Lys Glu Ile His Gln Ile Phe Glu Asp Leu Asp Lys Lys 
865                 870                 875                 880 


Leu Ala Leu Ala Ser Arg Phe Tyr Ile Pro Glu Gly Cys Ile Gln Arg 
                885                 890                 895     


Trp Ala Ala Glu Met Val Val Ala Leu Asp Ala Leu His Arg Glu Gly 
            900                 905                 910         


Ile Val Cys Arg Asp Leu Asn Pro Asn Asn Ile Leu Leu Asn Asp Arg 
        915                 920                 925             


Gly His Ile Gln Leu Thr Tyr Phe Ser Arg Trp Ser Glu Val Glu Asp 
    930                 935                 940                 


Ser Cys Asp Ser Asp Ala Ile Glu Arg Met Tyr Cys Ala Pro Glu Val 
945                 950                 955                 960 


Gly Ala Ile Thr Glu Glu Thr Glu Ala Cys Asp Trp Trp Ser Leu Gly 
                965                 970                 975     


Ala Val Leu Phe Glu Leu Leu Thr Gly Lys Thr Leu Val Glu Cys His 
            980                 985                 990         


Pro Ala Gly Ile Asn Thr His Thr  Thr Leu Asn Met Pro  Glu Cys Val 
        995                 1000                 1005             


Ser Glu  Glu Ala Arg Ser Leu  Ile Gln Gln Leu Leu  Gln Phe Asn 
    1010                 1015                 1020             


Pro Leu  Glu Arg Leu Gly Ala  Gly Val Ala Gly Val  Glu Asp Ile 
    1025                 1030                 1035             


Lys Ser  His Pro Phe Phe Thr  Pro Val Asp Trp Ala  Glu Leu Met 
    1040                 1045                 1050             


Arg 
    


<210>  7113
<211>  3845
<212>  DNA
<213>  Homosapiens

<400>  7113
actcttttat aataacaact gttggtgaac cattcatctg aaaactctta taattgtatg     60

gaagagatac agtgatttta agaaactaca caaagaacta tggcaaattc acaaaaactt    120

attccgacat tcagagttgt ttcctccatt tgctaaagga atagtgtttg ggcgatttga    180

tgaaactgtt atcgaagaga gaagacaatg tgctgaagac ctgctacagt tctctgccaa    240

tattcctgct ctttacaata gtaaacagct tgaagacttt ttcaaggctt ctccagtgac    300

agtgatctgg tatctcttac tgttgatgtg gattctcttg ctgagttaga tgatggaatg    360

gcttccaatc aaaattctcc cattagaact tttggtctca atctttcttc ggattcttca    420

gcactagggg ctgttgcttc tgacagtgaa cagagcaaaa cagaagaaga acgggaaagt    480

cgtagcctct ttcctggcag tttaaagccg aagcttggca agagagatta tttggagaaa    540

gcaggagaat taataaagct ggctttaaaa aaggaagaag aagacgacta tgaagctgct    600

tctgattttt ataggaaggg agttgattta ctcctagaag gtgttcaagg agagtcaagc    660

cctacccgtc gagaagctgt gaagagaaga acagccgagt acctcatgcg ggcagaaagt    720

atctctagtc tttatgggaa acctcagctt gatgatgtat ctcagcctcc aggatcacta    780

agttcaaggc ccctttggaa cctaaggagc cctgccgagg agctgaaggc cttcagagtc    840

cttggggtga ttgacaaggt tttacttgta atggacacaa ggacagaaca gactttcatt    900

ttaaaaggtc taaggaaaag cagtgaatac agcaggaaca gaaagaccat catcccccgc    960

tgtgtgccca acatggtgtg tctgcataag tacatcatct ctgaggagtc agtatttctt   1020

gtgctgcagc atgcggaagg tggcaaactg tggtcatata tcagtaaatt tctaaacaga   1080

agtcctgaag aaagctttga catcaaggaa gtgaaaaaac ctacacttgc aaaagttcac   1140

ctgcagcagc caacttctag tcctcaggac agcagtagct ttgaatccag aggaagtgat   1200

ggtggaagca tgcttaaagc tctgcctttg aagagtagtc ttactccaag ttctcaagat   1260

gacagcaacc aggaagatga tggccaagat agctctccaa agtggccaga ttctggttca   1320

agttcagaag aagaatgtac tactagttat ttaacattat gcaatgaata tgggcaagaa   1380

aagattgaac cagggtcttt gaatgaggag cccttcatga agactgaagg gaatggtgtt   1440

gatacaaaag ctattaaaag cttcccagca caccttgctg ctgacagtga cagccccagc   1500

acacagctga gagctcacga gctgaagttc ttccccaacg atgacccaga agcagttagt   1560

tctccaagaa catcagattc cctcagtaga tcaaaaaata gccccatgga attctttagg   1620

atagacagta aggatagcgc aagtgaactc ctgggacttg actttggaga aaaattgtat   1680

agtctaaaat cagaaccttt gaaaccattc tttactcttc cagatggaga cagtgcttct   1740

aggagtttta atactagtga aagcaaggta gagtttaaag ctcaggacac cattagcagg   1800

ggctcagatg actcagtgcc agttatttca tttaaagatg ctgcttttga tgatgtcagt   1860

ggtactgatg aaggaagacc tgatcttctt gtaaatttac ctggtgaatt ggagtcaaca   1920

agagaagctg cagcaatggg acctactaag tttacacaaa ctaatatagg gataatagaa   1980

aataaactct tggaagcccc tgatgtttta tgcctcaggc ttagtactga acaatgccaa   2040

gcacatgagg agaaaggcat agaggaactg agtgatccct ctgggcccaa atcctatagt   2100

ataacagaga aacactatgc acaggaggat cccaggatgt tatttgtagc agctgttgat   2160

catagtagtt caggagatat gtctttgtta cccagctcag atcctaagtt tcaaggactt   2220

ggagtggttg agtcagcagt aactgcaaac aacacagaag aaagcttatt ccgtatttgt   2280

agtccactct caggtgctaa tgaatatatt gcaagcacag acactttaaa aacagaagaa   2340

gtattgctgt ttacagatca gactgatgat ttggctaaag aggaaccaac ttctttattc   2400

cagagagact ctgagactaa gggtgaaagt ggtttagtgc tagaaggaga caaggaaata   2460

catcagattt ttgaggacct tgataaaaaa ttagcactag cctccaggtt ttacatccca   2520

gagggctgca ttcaaagatg ggcagctgaa atggtggtag cccttgatgc tttacataga   2580

gagggaattg tgtgccgcga tttgaaccca aacaacatct tattgaatga tagaggacac   2640

attcagctaa cgtattttag caggtggagt gaggttgaag attcctgtga cagcgatgcc   2700

atagagagaa tgtactgtgc cccagaggtt ggagcaatca ctgaagaaac tgaagcctgt   2760

gattggtgga gtttgggtgc tgtcctcttt gaacttctca ctggcaagac tctggttgaa   2820

tgccatccag caggaataaa tactcacact actttgaaca tgccagaatg tgtctctgaa   2880

gaggctcgct cactcattca acagctcttg cagttcaatc ctctggaacg acttggtgct   2940

ggagttgctg gtgttgaaga tatcaaatct catccatttt ttacccctgt ggattgggca   3000

gaactgatga gatgaacgta atgcagggtt atcttcacac attctgatct tctctgtgac   3060

aggcatctcc agcactgagg cacctctgac tcacagttac ttatggagca ccaaagcatt   3120

tggataaaga ccgttatagg aaatgggggg gaaatggcta aaagagaaca attcgtttac   3180

aattacaaga tattagctaa ttgtgccagg ggctgttata tacatatata cacaaccaag   3240

gtgtgatctg aatttaatcc acatttggtg ttgcagatga gttgtaaagc caactgaaag   3300

agttccttca agaagttcct ctgataggaa gctagaagtg tagaatgaag ttttacttga   3360

cagaaggacc tttacatggc agctaacagt gctttttgct gaccaggatt ggtttatatg   3420

attaaattaa tatttgctta ataatacact aaaagtatat gaacaatgtc atcaatgaaa   3480

cttaaaagcg agaaaaaaga atatacacat aatttctgac ggaaaacctg taccctgatg   3540

ctgtataatg tatgttgaat gtggtcccag attatttctg taagaagaca ctccatgttg   3600

tcagctttgt actctttgtt gatactgctt atttagagaa gggttcatat aaacactcac   3660

tctgtgtctt caacagcatc tttctttccc catctttcta ttttctgcac cctctgcttg   3720

ttccctcata ttctgttctt ccgactcctg ctaacacaca tgcaacaaaa aagggaaggg   3780

agtgcttatt tccctttgtg taaggactaa gaaatcatga tatcaaataa acatggtgaa   3840

acatt                                                               3845


<210>  7114
<211>  885
<212>  PRT
<213>  Homosapiens

<400>  7114

Met Ala Ser Asn Gln Asn Ser Pro Ile Arg Thr Phe Gly Leu Asn Leu 
1               5                   10                  15      


Ser Ser Asp Ser Ser Ala Leu Gly Ala Val Ala Ser Asp Ser Glu Gln 
            20                  25                  30          


Ser Lys Thr Glu Glu Glu Arg Glu Ser Arg Ser Leu Phe Pro Gly Ser 
        35                  40                  45              


Leu Lys Pro Lys Leu Gly Lys Arg Asp Tyr Leu Glu Lys Ala Gly Glu 
    50                  55                  60                  


Leu Ile Lys Leu Ala Leu Lys Lys Glu Glu Glu Asp Asp Tyr Glu Ala 
65                  70                  75                  80  


Ala Ser Asp Phe Tyr Arg Lys Gly Val Asp Leu Leu Leu Glu Gly Val 
                85                  90                  95      


Gln Gly Glu Ser Ser Pro Thr Arg Arg Glu Ala Val Lys Arg Arg Thr 
            100                 105                 110         


Ala Glu Tyr Leu Met Arg Ala Glu Ser Ile Ser Ser Leu Tyr Gly Lys 
        115                 120                 125             


Pro Gln Leu Asp Asp Val Ser Gln Pro Pro Gly Ser Leu Ser Ser Arg 
    130                 135                 140                 


Pro Leu Trp Asn Leu Arg Ser Pro Ala Glu Glu Leu Lys Ala Phe Arg 
145                 150                 155                 160 


Val Leu Gly Val Ile Asp Lys Val Leu Leu Val Met Asp Thr Arg Thr 
                165                 170                 175     


Glu Gln Thr Phe Ile Leu Lys Gly Leu Arg Lys Ser Ser Glu Tyr Ser 
            180                 185                 190         


Arg Asn Arg Lys Thr Ile Ile Pro Arg Cys Val Pro Asn Met Val Cys 
        195                 200                 205             


Leu His Lys Tyr Ile Ile Ser Glu Glu Ser Val Phe Leu Val Leu Gln 
    210                 215                 220                 


His Ala Glu Gly Gly Lys Leu Trp Ser Tyr Ile Ser Lys Phe Leu Asn 
225                 230                 235                 240 


Arg Ser Pro Glu Glu Ser Phe Asp Ile Lys Glu Val Lys Lys Pro Thr 
                245                 250                 255     


Leu Ala Lys Val His Leu Gln Gln Pro Thr Ser Ser Pro Gln Asp Ser 
            260                 265                 270         


Ser Ser Phe Glu Ser Arg Gly Ser Asp Gly Gly Ser Met Leu Lys Ala 
        275                 280                 285             


Leu Pro Leu Lys Ser Ser Leu Thr Pro Ser Ser Gln Asp Asp Ser Asn 
    290                 295                 300                 


Gln Glu Asp Asp Gly Gln Asp Ser Ser Pro Lys Trp Pro Asp Ser Gly 
305                 310                 315                 320 


Ser Ser Ser Glu Glu Glu Cys Thr Thr Ser Tyr Leu Thr Leu Cys Asn 
                325                 330                 335     


Glu Tyr Gly Gln Glu Lys Ile Glu Pro Gly Ser Leu Asn Glu Glu Pro 
            340                 345                 350         


Phe Met Lys Thr Glu Gly Asn Gly Val Asp Thr Lys Ala Ile Lys Ser 
        355                 360                 365             


Phe Pro Ala His Leu Ala Ala Asp Ser Asp Ser Pro Ser Thr Gln Leu 
    370                 375                 380                 


Arg Ala His Glu Leu Lys Phe Phe Pro Asn Asp Asp Pro Glu Ala Val 
385                 390                 395                 400 


Ser Ser Pro Arg Thr Ser Asp Ser Leu Ser Arg Ser Lys Asn Ser Pro 
                405                 410                 415     


Met Glu Phe Phe Arg Ile Asp Ser Lys Asp Ser Ala Ser Glu Leu Leu 
            420                 425                 430         


Gly Leu Asp Phe Gly Glu Lys Leu Tyr Ser Leu Lys Ser Glu Pro Leu 
        435                 440                 445             


Lys Pro Phe Phe Thr Leu Pro Asp Gly Asp Ser Ala Ser Arg Ser Phe 
    450                 455                 460                 


Asn Thr Ser Glu Ser Lys Val Glu Phe Lys Ala Gln Asp Thr Ile Ser 
465                 470                 475                 480 


Arg Gly Ser Asp Asp Ser Val Pro Val Ile Ser Phe Lys Asp Ala Ala 
                485                 490                 495     


Phe Asp Asp Val Ser Gly Thr Asp Glu Gly Arg Pro Asp Leu Leu Val 
            500                 505                 510         


Asn Leu Pro Gly Glu Leu Glu Ser Thr Arg Glu Ala Ala Ala Met Gly 
        515                 520                 525             


Pro Thr Lys Phe Thr Gln Thr Asn Ile Gly Ile Ile Glu Asn Lys Leu 
    530                 535                 540                 


Leu Glu Ala Pro Asp Val Leu Cys Leu Arg Leu Ser Thr Glu Gln Cys 
545                 550                 555                 560 


Gln Ala His Glu Glu Lys Gly Ile Glu Glu Leu Ser Asp Pro Ser Gly 
                565                 570                 575     


Pro Lys Ser Tyr Ser Ile Thr Glu Lys His Tyr Ala Gln Glu Asp Pro 
            580                 585                 590         


Arg Met Leu Phe Val Ala Ala Val Asp His Ser Ser Ser Gly Asp Met 
        595                 600                 605             


Ser Leu Leu Pro Ser Ser Asp Pro Lys Phe Gln Gly Leu Gly Val Val 
    610                 615                 620                 


Glu Ser Ala Val Thr Ala Asn Asn Thr Glu Glu Ser Leu Phe Arg Ile 
625                 630                 635                 640 


Cys Ser Pro Leu Ser Gly Ala Asn Glu Tyr Ile Ala Ser Thr Asp Thr 
                645                 650                 655     


Leu Lys Thr Glu Glu Val Leu Leu Phe Thr Asp Gln Thr Asp Asp Leu 
            660                 665                 670         


Ala Lys Glu Glu Pro Thr Ser Leu Phe Gln Arg Asp Ser Glu Thr Lys 
        675                 680                 685             


Gly Glu Ser Gly Leu Val Leu Glu Gly Asp Lys Glu Ile His Gln Ile 
    690                 695                 700                 


Phe Glu Asp Leu Asp Lys Lys Leu Ala Leu Ala Ser Arg Phe Tyr Ile 
705                 710                 715                 720 


Pro Glu Gly Cys Ile Gln Arg Trp Ala Ala Glu Met Val Val Ala Leu 
                725                 730                 735     


Asp Ala Leu His Arg Glu Gly Ile Val Cys Arg Asp Leu Asn Pro Asn 
            740                 745                 750         


Asn Ile Leu Leu Asn Asp Arg Gly His Ile Gln Leu Thr Tyr Phe Ser 
        755                 760                 765             


Arg Trp Ser Glu Val Glu Asp Ser Cys Asp Ser Asp Ala Ile Glu Arg 
    770                 775                 780                 


Met Tyr Cys Ala Pro Glu Val Gly Ala Ile Thr Glu Glu Thr Glu Ala 
785                 790                 795                 800 


Cys Asp Trp Trp Ser Leu Gly Ala Val Leu Phe Glu Leu Leu Thr Gly 
                805                 810                 815     


Lys Thr Leu Val Glu Cys His Pro Ala Gly Ile Asn Thr His Thr Thr 
            820                 825                 830         


Leu Asn Met Pro Glu Cys Val Ser Glu Glu Ala Arg Ser Leu Ile Gln 
        835                 840                 845             


Gln Leu Leu Gln Phe Asn Pro Leu Glu Arg Leu Gly Ala Gly Val Ala 
    850                 855                 860                 


Gly Val Glu Asp Ile Lys Ser His Pro Phe Phe Thr Pro Val Asp Trp 
865                 870                 875                 880 


Ala Glu Leu Met Arg 
                885 


<210>  7115
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  7115
tctgagcttc aggtaaccaa gtgtttgctc tgcagaatac tttacctggg cacccaagtc     60

ttccttccag cattcctgct gctacagcct atttgctgag taaccagggg ttacagcagc    120

gttgccaggc aacgagggac agcggtcctg ttgaagagcc atttgtcaca ctgaggggac    180

tggttgaaat gcaataaaga aatgatacca gcagctactc atgtcttcgc cattgctaag    240

aacgtcgttg gtattacctt actctgagaa cgtgtctgca gtttccagaa aatggagtat    300

cgcaacatca cttaaagtac cctgcttcaa agtattgctg gcaagtggcg tgggcctgat    360

tatttattta gaaatgcttt atcaggagga gaatgctttt ttgtaaacat gaattgccca    420

gttctttcat tgggctctgg cttcttgttt caggtcattg aaatgttgat ctttgcctat    480

tttgcttcaa tatccttgac tgagtcacga ggtcttttcc caaggctgga gaacgtggga    540

gctttcaaga aagtttccat cgtgccaacc caagcagtat gtggactccc agaccgaagc    600

actttttgtc acagctctgc tgctgctgaa agtattcagt tctgtaccca gcggttttgt    660

attcaggatt gcccatacag atcttcacac cctacctaca ctgccctttt ctcagcaggc    720

ctcagtagct gcatcacacc agacaagaat gatctgcatc ctaacgccca tagcaattct    780

gcaagtttta tttttggaaa tcacaagagc tgcttttctt ctcctccttc tccaaagctg    840

atggcatcat ttaccttagc tgtatggctg aaacctgagc aacaaggtgt aatgtgtgtt    900

atagaaaaga cagtagatgg gcagattgtg ttcaaactta caatatctga gaaagagacc    960

atgttttatt atcgcacagt aaatggtttg caacctccaa taaaagtaat gacactgggg   1020

agaattcttg tgaagaaatg gattcatctt agtgtgcagg tgcatcagac aaaaatcagc   1080

ttctttatca atggcgtgga gaaggatcat acacctttca atgcaagaac tctaagtggt   1140

tcaattacag attttgcatc tggtactgtg caaataggac agagtttaaa tggtttagag   1200

cagtttgtcg gaagaatgca agattttcga ttataccaag tggcacttac aaacagagag   1260

attctggaag tcttctctgg agatcttctc agattgcatg cccaatcaca ttgccgttgc   1320

cctggcagcc acccgcgggt ccaccctttg gcacagcggt actgcattcc taatgatgca   1380

ggagacacag ctgataatag agtgtcacgg ttgaatcctg aagcccatcc tctctctttt   1440

gtcaatgata atgatgttgg tacttcatgg gtttcaaatg tgtttacaaa cattacacag   1500

cttaatcaag gagtgactat ttcagttgat ttggaaaatg gacagtatca ggtgttttat   1560

attatcattc agttctttag tccacaacca acggaaataa ggattcaaag gaagaaggaa   1620

aatagtttag attgggagga ctggcaatat tttgccagga attgtggtgc ttttggaatg   1680

aaaaacaatg gagatttgga aaaacctgat tctgtcaact gtcttcagct ttccaatttt   1740

actccatatt cccgtggcaa tgtcacattt agcatcctga cacctggacc aaattatcgt   1800

cctggataca ataacttcta taatacccca tctcttcaag agttcgtaaa agccacgcaa   1860

ataaggtttc attttcatgg gcagtactat acaactgaga ctgctgttaa cctcagacac   1920

agatattatg cagtggacga aatcaccatt agtgggagat gtcagtgcca tggtcatgcc   1980

gataactgcg acacaacaag ccagccatat agatgcctct gctcccagga gagcttcact   2040

gaaggacttc attgtgatcg ctgcttgcct ctttataatg acaagccttt ccgccaaggt   2100

gatcaagttt acgctttcaa ttgtaaacct tgtcaatgca acagccattc caaaagctgc   2160

cattacaaca tctctgtaga cccatttcct tttgagcact tcagaggggg aggaggagtt   2220

tgtgatgatt gtgagcataa cactacagga aggaactgtg agctgtgcaa ggattacttt   2280

ttccgacaag ttggtgcaga tccttcggcc atagatgttt gcaaaccctg tgactgtgat   2340

acagttggca ctagaaatgg tagcattctt tgtgatcaga ttggaggaca gtgtaattgt   2400

aagagacacg tgtctggcag gcagtgcaat cagtgccaga atggattcta caatctacaa   2460

gagttggatc ctgatggctg cagtccctgt aactgcaata cctctgggac agtggatgga   2520

gatattacct gtcaccaaaa ttcaggccag tgcaagtgca aagcaaacgt tattgggctt   2580

aggtgtgatc attgcaattt tggatttaaa tttctccgaa gctttaatga tgttggatgt   2640

gagccctgcc agtgtaacct ccatggctca gtgaacaaat tctgcaatcc tcactctggg   2700

cagtgtgagt gcaaaaaaga agccaaagga cttcagtgtg acacctgcag agaaaacttt   2760

tatgggttag atgtcaccaa ttgtaaggcc tgtgactgtg acacagctgg atccctccct   2820

gggactgtct gtaatgctaa gacagggcag tgcatctgca agcccaatgt tgaagggaga   2880

cagtgcaata aatgtttgga gggaaacttc tacctacggc aaaataattc tttcctctgt   2940

ctgccttgca actgtgataa gactgggaca ataaatggct ctctgctgtg taacaaatca   3000

acaggacaat gtccttgcaa attaggggta acaggtcttc gctgtaatca gtgtgagcct   3060

cacaggtaca atttgaccat tgacaatttt caacactgcc agatgtgtga gtgtgattcc   3120

ttggggacat tacctgggac catttgtgac ccaatcagtg gccagtgcct gtgtgtgcct   3180

aatcgtcaag gaagaaggtg taatcagtgt caaccaggtt tttatatttc tccaggcaat   3240

gccactggct gcctgccatg ctcatgccat acaactggtg cagttaatca catctgtaat   3300

agcctgactg gtcagtgtgt ttgccaagat gcttccattg ctgggcaacg ttgtgaccaa   3360

tgcaaagacc attactttgg atttgatcct cagactggaa gatgtcagcc ttgtaattgt   3420

catctctcag gagccttgaa tgaaacctgt cacttggtca caggccagtg tttctgtaaa   3480

caatttgtca ctggctcaaa gtgtgatgct tgtgttccca gtgcaagcca cttggatgtc   3540

aacaatctat tgggttgcag caaaactcca ttccagcaac ctccgcccag aggacaagtt   3600

caaagttctt ctgctatcaa tctctcctgg agtccacctg attctccaaa tgcccactgg   3660

cttacttaca gtttactcag ggatggtttt gaaatctaca caacagagga tcaataccca   3720

tacagtattc aatacttctt agacacagac ctgttaccat ataccaaata ttcctattac   3780

attgagacca ccaatgtgca tggttcaaca aggagtgtag ctgtcactta caagacaaaa   3840

ccaggggtcc cagagggaaa cttgacttta agttatatca ttcctattgg ctcagactct   3900

gtgacactta cctggacaac actctcaaat caatctggtc ccatagagaa atatattttg   3960

tcctgtgccc ctttggctgg tggtcagcca tgtgtttcct acgaaggtca tgaaacctca   4020

gctaccatct ggaatctggt tccatttgcc aagtacgatt tttctgtaca ggcgtgtact   4080

agcgggggct gtttacacag cttgcccatt acagtgacca cagcccaggc ccctccccaa   4140

agactaagtc cacctaagat gcagaaaatc agttctacag aacttcatgt agaatggtct   4200

ccaccagcgg aactaaatgg aataattata agatatgaac tatacatgag aagactgaga   4260

tctactaaag aaaccacatc tgaggaaagt cgagtttttc agagcagtgg ttggctcagt   4320

cctcattcat ttgtagaatc ggccaatgaa aatgcattaa aacctcctca aacaatgaca   4380

accatcactg gcttggagcc atacaccaag tatgagttca gagtcttagc tgtgaatatg   4440

gctggaagtg tgtcttctgc ctgggtctca gaaagaacgg gagaatcagc acctgtattc   4500

atgatccctc cttcagtctt tcccctctct tcgtactctc tcaatatctc ctgggagaag   4560

ccagcagata atgttacaag aggaaaagtt gtggggtatg acatcaatat gctttctgaa   4620

caatcacctc aacagtctat tcccatggcg ttttcacagc tgttgcacac tgctaaatcc   4680

caagaactat cttacactgt agaaggactg aaaccttata ggatatatga gtttactatt   4740

actctctgca attcagttgg ttgtgtgacc agtgcttcgg gagcaggaca aactttagca   4800

gcagcaccag cacaactgag gccacctctg gttaaaggaa tcaacagcac aacaatccat   4860

cttaggtggt ttccacctga agaactgaat ggaccctctc ctatatatca gctggaaagg   4920

agagagtcat ctctaccagc tctgatgacc acgatgatga aaggaatccg tttcatagga   4980

aatgggtatt gtaaatttcc cagctccact cacccagtca atacagactt cactggcatt   5040

aaggccagct ttcgaacaaa agtgcctgaa ggtttgattg tctttgcagc atcacctggc   5100

aatcaggaag agtattttgc acttcagttg aagaagggac gtctttattt tctttttgat   5160

cctcaggggt caccagtgga agtaactaca actaatgatc atggcaaaca atatagtgat   5220

ggaaaatggc atgaaataat tgctattagg catcaggctt ttggccaaat cactctggat   5280

gggatatata caggttcctc tgccatcctg aatggtagta ctgttattgg agataacaca   5340

ggagtctttc tgggagggct cccgcgaagt tataccatcc tcaggaagga tcctgagata   5400

atccaaaaag gttttgtggg ctgtctcaag gatgtacatt ttatgaagaa ttacaatccg   5460

tcagctattt gggaacctct ggattggcag agttctgaag aacaaatcaa cgtgtataac   5520

agctgggagg gatgtcccgc ttcattaaat gagggagctc agttcctagg agcagggttc   5580

ctggaacttc atccatatat gtttcatggt ggaatgaact ttgagatttc ctttaagttc   5640

agaactgacc aattaaatgg attgcttctt ttcgtttata acaaagatgg acctgatttt   5700

cttgctatgg agctgaaaag tggaatattg accttccggt taaataccag tcttgccttt   5760

acacaagtgg atctattgct ggggctatcc tattgtaatg gaaagtggaa taaagtcatt   5820

attaaaaagg aaggctcttt catatcagca agtgtgaatg gactgatgaa gcatgcatcg   5880

gagtccggag accagccact ggtggtgaat tcaccagttt atgtgggagg aatcccacag   5940

gaactgctga actcttatca acatttgtgt ttggaacaag gtttcggtgg ttgcatgaag   6000

gatgttaaat ttacacgggg tgctgtcgtt aacttggcat ctgtgtccag cggtgctgtc   6060

agagtcaatc tggatggatg cctatcaact gacagtgctg ttaactgcag gggaaatgac   6120

tccatcctgg tttaccaggg aaaagagcag agtgtttacg agggtggtct ccagcctttt   6180

acagaatacc tgtatcgagt gatagcctcg catgaaggag gttcagtata tagtgattgg   6240

agtcgaggac gtacaacagg agcagctcca caaagtgtgc caactccctc aagagtccgc   6300

agcttaaatg gatacagcat tgaggtgacc tgggatgaac ctgttgtcag aggtgtaatt   6360

gagaagtaca ttctgaaagc ctatagtgag gacagcaccc gtccaccccg catgccctct   6420

gccagtgctg aatttgtcaa tacaagcaac ctcacaggca tattgacagg cttgctaccc   6480

ttcaaaaact atgcagtaac cctaactgct tgcactttgg ctggctgtac tgagagctca   6540

catgcattga acatctctac tccacaagaa gccccacaag aggttcagcc accagtagcc   6600

aaatcccttc ccagttcttt gctgctctcc tggaacccac ccaaaaaggc aaatggtatt   6660

ataactcagt actgtttata catggatggg aggctgatct attcaggcag tgaggagaac   6720

tacatagtca cagatttagc agtatttaca ccccaccagt ttctactaag tgcatgcaca   6780

catgtgggct gtacaaacag ttcctgggtc ctactgtaca cagcacagct gccaccagaa   6840

cacgtggatt ccccagttct gactgtcctg gattctagaa ctatacacat acagtggaaa   6900

caaccaagaa aaataagtgg gattctggaa cgctatgtat tatatatgtc aaaccataca   6960

catgatttta caatttggag tgtcatctat aacagtacag aacttttcca ggatcatatg   7020

ctacaatacg ttttacctgg taataaatat ctcatcaagc tgggagcttg cacaggtggt   7080

gggtgcacag tgagtgaggc cagtgaggcc ctaactgacg aggacatacc cgaaggcgtg   7140

ccagccccca aagcccactc atattcacct gactccttta atgtctcctg gactgagcct   7200

gaatatccga atggtgttat cacgagttat ggattatatc tagatggtat attaatccac   7260

aattcctcag aactcagcta tcgtgcttac ggatttgctc cttggagttt acattccttc   7320

agagtccaag catgcacggc caaaggttgt gctctgggcc cactggtgga aaatcgaact   7380

ctagaagctc ctcctgaagg aacagtaaat gtgtttgtca aaacacaggg atcccggaaa   7440

gcccacgtga ggtgggaagc accttttcgc cctaatggac tcttaacaca ctcagtcctt   7500

ttcactggga tattctatgt agacccagta ggtaataact acacccttct gaatgtcaca   7560

aaagtcatgt acagcggaga agagacaaac ctttgggtgc tcatcgatgg gctggttcct   7620

tttaccaact atactgtaca agtgaatatt tcaaatagcc aaggcagctt gataactgat   7680

cctataacaa ttgcaatgcc tccaggagct ccagatggcg tgctgcctcc caggctttca   7740

tctgccactc caaccagtct tcaggttgtc tggtctacac cagctcgtaa taacgctcct   7800

ggctctccca gataccaact ccagatgagg tctggcgact ccacccatgg atttctagag   7860

ttattttcca atccttctgc atcgttaagc tatgaagtga gtgatctcca accgtacaca   7920

gagtatatgt ttcggttggt tgcctccaat ggatttggca gtgcacatag ttcttggatt   7980

ccattcatga ccgcagagga caaacctgga cctgtagttc ctccgattct tctggatgtg   8040

aagtcaagaa tgatgttggt cacctggcag catcctagaa aatccaatgg ggttattacc   8100

cattataaca tttatctaca tggccgtcta tacttgagaa ctcctggaaa tgtcactaat   8160

tgcacagtga tgcatttaca cccatacact gc                                 8192


<210>  7116
<211>  4000
<212>  PRT
<213>  Homosapiens

<400>  7116

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              


Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  


Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  


Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      


Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         


Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             


Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 


Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 


Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     


Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         


Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             


Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 


Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 


Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     


Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         


Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             


Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 


Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 


Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     


Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         


Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             


Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 


Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 


Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     


Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         


Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             


Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 


Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val 
465                 470                 475                 480 


Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     


Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         


Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             


Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 


Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 


Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     


Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         


Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             


Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 


Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 


Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             


Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 


Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 


Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     


Arg Ser Phe Asn Asp Val Gly Cys Glu Pro Cys Gln Cys Asn Leu His 
            740                 745                 750         


Gly Ser Val Asn Lys Phe Cys Asn Pro His Ser Gly Gln Cys Glu Cys 
        755                 760                 765             


Lys Lys Glu Ala Lys Gly Leu Gln Cys Asp Thr Cys Arg Glu Asn Phe 
    770                 775                 780                 


Tyr Gly Leu Asp Val Thr Asn Cys Lys Ala Cys Asp Cys Asp Thr Ala 
785                 790                 795                 800 


Gly Ser Leu Pro Gly Thr Val Cys Asn Ala Lys Thr Gly Gln Cys Ile 
                805                 810                 815     


Cys Lys Pro Asn Val Glu Gly Arg Gln Cys Asn Lys Cys Leu Glu Gly 
            820                 825                 830         


Asn Phe Tyr Leu Arg Gln Asn Asn Ser Phe Leu Cys Leu Pro Cys Asn 
        835                 840                 845             


Cys Asp Lys Thr Gly Thr Ile Asn Gly Ser Leu Leu Cys Asn Lys Ser 
    850                 855                 860                 


Thr Gly Gln Cys Pro Cys Lys Leu Gly Val Thr Gly Leu Arg Cys Asn 
865                 870                 875                 880 


Gln Cys Glu Pro His Arg Tyr Asn Leu Thr Ile Asp Asn Phe Gln His 
                885                 890                 895     


Cys Gln Met Cys Glu Cys Asp Ser Leu Gly Thr Leu Pro Gly Thr Ile 
            900                 905                 910         


Cys Asp Pro Ile Ser Gly Gln Cys Leu Cys Val Pro Asn Arg Gln Gly 
        915                 920                 925             


Arg Arg Cys Asn Gln Cys Gln Pro Gly Phe Tyr Ile Ser Pro Gly Asn 
    930                 935                 940                 


Ala Thr Gly Cys Leu Pro Cys Ser Cys His Thr Thr Gly Ala Val Asn 
945                 950                 955                 960 


His Ile Cys Asn Ser Leu Thr Gly Gln Cys Val Cys Gln Asp Ala Ser 
                965                 970                 975     


Ile Ala Gly Gln Arg Cys Asp Gln Cys Lys Asp His Tyr Phe Gly Phe 
            980                 985                 990         


Asp Pro Gln Thr Gly Arg Cys Gln  Pro Cys Asn Cys His  Leu Ser Gly 
        995                 1000                 1005             


Ala Leu  Asn Glu Thr Cys His  Leu Val Thr Gly Gln  Cys Phe Cys 
    1010                 1015                 1020             


Lys Gln  Phe Val Thr Gly Ser  Lys Cys Asp Ala Cys  Val Pro Ser 
    1025                 1030                 1035             


Ala Ser  His Leu Asp Val Asn  Asn Leu Leu Gly Cys  Ser Lys Thr 
    1040                 1045                 1050             


Pro Phe  Gln Gln Pro Pro Pro  Arg Gly Gln Val Gln  Ser Ser Ser 
    1055                 1060                 1065             


Ala Ile  Asn Leu Ser Trp Ser  Pro Pro Asp Ser Pro  Asn Ala His 
    1070                 1075                 1080             


Trp Leu  Thr Tyr Ser Leu Leu  Arg Asp Gly Phe Glu  Ile Tyr Thr 
    1085                 1090                 1095             


Thr Glu  Asp Gln Tyr Pro Tyr  Ser Ile Gln Tyr Phe  Leu Asp Thr 
    1100                 1105                 1110             


Asp Leu  Leu Pro Tyr Thr Lys  Tyr Ser Tyr Tyr Ile  Glu Thr Thr 
    1115                 1120                 1125             


Asn Val  His Gly Ser Thr Arg  Ser Val Ala Val Thr  Tyr Lys Thr 
    1130                 1135                 1140             


Lys Pro  Gly Val Pro Glu Gly  Asn Leu Thr Leu Ser  Tyr Ile Ile 
    1145                 1150                 1155             


Pro Ile  Gly Ser Asp Ser Val  Thr Leu Thr Trp Thr  Thr Leu Ser 
    1160                 1165                 1170             


Asn Gln  Ser Gly Pro Ile Glu  Lys Tyr Ile Leu Ser  Cys Ala Pro 
    1175                 1180                 1185             


Leu Ala  Gly Gly Gln Pro Cys  Val Ser Tyr Glu Gly  His Glu Thr 
    1190                 1195                 1200             


Ser Ala  Thr Ile Trp Asn Leu  Val Pro Phe Ala Lys  Tyr Asp Phe 
    1205                 1210                 1215             


Ser Val  Gln Ala Cys Thr Ser  Gly Gly Cys Leu His  Ser Leu Pro 
    1220                 1225                 1230             


Ile Thr  Val Thr Thr Ala Gln  Ala Pro Pro Gln Arg  Leu Ser Pro 
    1235                 1240                 1245             


Pro Lys  Met Gln Lys Ile Ser  Ser Thr Glu Leu His  Val Glu Trp 
    1250                 1255                 1260             


Ser Pro  Pro Ala Glu Leu Asn  Gly Ile Ile Ile Arg  Tyr Glu Leu 
    1265                 1270                 1275             


Tyr Met  Arg Arg Leu Arg Ser  Thr Lys Glu Thr Thr  Ser Glu Glu 
    1280                 1285                 1290             


Ser Arg  Val Phe Gln Ser Ser  Gly Trp Leu Ser Pro  His Ser Phe 
    1295                 1300                 1305             


Val Glu  Ser Ala Asn Glu Asn  Ala Leu Lys Pro Pro  Gln Thr Met 
    1310                 1315                 1320             


Thr Thr  Ile Thr Gly Leu Glu  Pro Tyr Thr Lys Tyr  Glu Phe Arg 
    1325                 1330                 1335             


Val Leu  Ala Val Asn Met Ala  Gly Ser Val Ser Ser  Ala Trp Val 
    1340                 1345                 1350             


Ser Glu  Arg Thr Gly Glu Ser  Ala Pro Val Phe Met  Ile Pro Pro 
    1355                 1360                 1365             


Ser Val  Phe Pro Leu Ser Ser  Tyr Ser Leu Asn Ile  Ser Trp Glu 
    1370                 1375                 1380             


Lys Pro  Ala Asp Asn Val Thr  Arg Gly Lys Val Val  Gly Tyr Asp 
    1385                 1390                 1395             


Ile Asn  Met Leu Ser Glu Gln  Ser Pro Gln Gln Ser  Ile Pro Met 
    1400                 1405                 1410             


Ala Phe  Ser Gln Leu Leu His  Thr Ala Lys Ser Gln  Glu Leu Ser 
    1415                 1420                 1425             


Tyr Thr  Val Glu Gly Leu Lys  Pro Tyr Arg Ile Tyr  Glu Phe Thr 
    1430                 1435                 1440             


Ile Thr  Leu Cys Asn Ser Val  Gly Cys Val Thr Ser  Ala Ser Gly 
    1445                 1450                 1455             


Ala Gly  Gln Thr Leu Ala Ala  Ala Pro Ala Gln Leu  Arg Pro Pro 
    1460                 1465                 1470             


Leu Val  Lys Gly Ile Asn Ser  Thr Thr Ile His Leu  Arg Trp Phe 
    1475                 1480                 1485             


Pro Pro  Glu Glu Leu Asn Gly  Pro Ser Pro Ile Tyr  Gln Leu Glu 
    1490                 1495                 1500             


Arg Arg  Glu Ser Ser Leu Pro  Ala Leu Met Thr Thr  Met Met Lys 
    1505                 1510                 1515             


Gly Ile  Arg Phe Ile Gly Asn  Gly Tyr Cys Lys Phe  Pro Ser Ser 
    1520                 1525                 1530             


Thr His  Pro Val Asn Thr Asp  Phe Thr Gly Ile Lys  Ala Ser Phe 
    1535                 1540                 1545             


Arg Thr  Lys Val Pro Glu Gly  Leu Ile Val Phe Ala  Ala Ser Pro 
    1550                 1555                 1560             


Gly Asn  Gln Glu Glu Tyr Phe  Ala Leu Gln Leu Lys  Lys Gly Arg 
    1565                 1570                 1575             


Leu Tyr  Phe Leu Phe Asp Pro  Gln Gly Ser Pro Val  Glu Val Thr 
    1580                 1585                 1590             


Thr Thr  Asn Asp His Gly Lys  Gln Tyr Ser Asp Gly  Lys Trp His 
    1595                 1600                 1605             


Glu Ile  Ile Ala Ile Arg His  Gln Ala Phe Gly Gln  Ile Thr Leu 
    1610                 1615                 1620             


Asp Gly  Ile Tyr Thr Gly Ser  Ser Ala Ile Leu Asn  Gly Ser Thr 
    1625                 1630                 1635             


Val Ile  Gly Asp Asn Thr Gly  Val Phe Leu Gly Gly  Leu Pro Arg 
    1640                 1645                 1650             


Ser Tyr  Thr Ile Leu Arg Lys  Asp Pro Glu Ile Ile  Gln Lys Gly 
    1655                 1660                 1665             


Phe Val  Gly Cys Leu Lys Asp  Val His Phe Met Lys  Asn Tyr Asn 
    1670                 1675                 1680             


Pro Ser  Ala Ile Trp Glu Pro  Leu Asp Trp Gln Ser  Ser Glu Glu 
    1685                 1690                 1695             


Gln Ile  Asn Val Tyr Asn Ser  Trp Glu Gly Cys Pro  Ala Ser Leu 
    1700                 1705                 1710             


Asn Glu  Gly Ala Gln Phe Leu  Gly Ala Gly Phe Leu  Glu Leu His 
    1715                 1720                 1725             


Pro Tyr  Met Phe His Gly Gly  Met Asn Phe Glu Ile  Ser Phe Lys 
    1730                 1735                 1740             


Phe Arg  Thr Asp Gln Leu Asn  Gly Leu Leu Leu Phe  Val Tyr Asn 
    1745                 1750                 1755             


Lys Asp  Gly Pro Asp Phe Leu  Ala Met Glu Leu Lys  Ser Gly Ile 
    1760                 1765                 1770             


Leu Thr  Phe Arg Leu Asn Thr  Ser Leu Ala Phe Thr  Gln Val Asp 
    1775                 1780                 1785             


Leu Leu  Leu Gly Leu Ser Tyr  Cys Asn Gly Lys Trp  Asn Lys Val 
    1790                 1795                 1800             


Ile Ile  Lys Lys Glu Gly Ser  Phe Ile Ser Ala Ser  Val Asn Gly 
    1805                 1810                 1815             


Leu Met  Lys His Ala Ser Glu  Ser Gly Asp Gln Pro  Leu Val Val 
    1820                 1825                 1830             


Asn Ser  Pro Val Tyr Val Gly  Gly Ile Pro Gln Glu  Leu Leu Asn 
    1835                 1840                 1845             


Ser Tyr  Gln His Leu Cys Leu  Glu Gln Gly Phe Gly  Gly Cys Met 
    1850                 1855                 1860             


Lys Asp  Val Lys Phe Thr Arg  Gly Ala Val Val Asn  Leu Ala Ser 
    1865                 1870                 1875             


Val Ser  Ser Gly Ala Val Arg  Val Asn Leu Asp Gly  Cys Leu Ser 
    1880                 1885                 1890             


Thr Asp  Ser Ala Val Asn Cys  Arg Gly Asn Asp Ser  Ile Leu Val 
    1895                 1900                 1905             


Tyr Gln  Gly Lys Glu Gln Ser  Val Tyr Glu Gly Gly  Leu Gln Pro 
    1910                 1915                 1920             


Phe Thr  Glu Tyr Leu Tyr Arg  Val Ile Ala Ser His  Glu Gly Gly 
    1925                 1930                 1935             


Ser Val  Tyr Ser Asp Trp Ser  Arg Gly Arg Thr Thr  Gly Ala Ala 
    1940                 1945                 1950             


Pro Gln  Ser Val Pro Thr Pro  Ser Arg Val Arg Ser  Leu Asn Gly 
    1955                 1960                 1965             


Tyr Ser  Ile Glu Val Thr Trp  Asp Glu Pro Val Val  Arg Gly Val 
    1970                 1975                 1980             


Ile Glu  Lys Tyr Ile Leu Lys  Ala Tyr Ser Glu Asp  Ser Thr Arg 
    1985                 1990                 1995             


Pro Pro  Arg Met Pro Ser Ala  Ser Ala Glu Phe Val  Asn Thr Ser 
    2000                 2005                 2010             


Asn Leu  Thr Gly Ile Leu Thr  Gly Leu Leu Pro Phe  Lys Asn Tyr 
    2015                 2020                 2025             


Ala Val  Thr Leu Thr Ala Cys  Thr Leu Ala Gly Cys  Thr Glu Ser 
    2030                 2035                 2040             


Ser His  Ala Leu Asn Ile Ser  Thr Pro Gln Glu Ala  Pro Gln Glu 
    2045                 2050                 2055             


Val Gln  Pro Pro Val Ala Lys  Ser Leu Pro Ser Ser  Leu Leu Leu 
    2060                 2065                 2070             


Ser Trp  Asn Pro Pro Lys Lys  Ala Asn Gly Ile Ile  Thr Gln Tyr 
    2075                 2080                 2085             


Cys Leu  Tyr Met Asp Gly Arg  Leu Ile Tyr Ser Gly  Ser Glu Glu 
    2090                 2095                 2100             


Asn Tyr  Ile Val Thr Asp Leu  Ala Val Phe Thr Pro  His Gln Phe 
    2105                 2110                 2115             


Leu Leu  Ser Ala Cys Thr His  Val Gly Cys Thr Asn  Ser Ser Trp 
    2120                 2125                 2130             


Val Leu  Leu Tyr Thr Ala Gln  Leu Pro Pro Glu His  Val Asp Ser 
    2135                 2140                 2145             


Pro Val  Leu Thr Val Leu Asp  Ser Arg Thr Ile His  Ile Gln Trp 
    2150                 2155                 2160             


Lys Gln  Pro Arg Lys Ile Ser  Gly Ile Leu Glu Arg  Tyr Val Leu 
    2165                 2170                 2175             


Tyr Met  Ser Asn His Thr His  Asp Phe Thr Ile Trp  Ser Val Ile 
    2180                 2185                 2190             


Tyr Asn  Ser Thr Glu Leu Phe  Gln Asp His Met Leu  Gln Tyr Val 
    2195                 2200                 2205             


Leu Pro  Gly Asn Lys Tyr Leu  Ile Lys Leu Gly Ala  Cys Thr Gly 
    2210                 2215                 2220             


Gly Gly  Cys Thr Val Ser Glu  Ala Ser Glu Ala Leu  Thr Asp Glu 
    2225                 2230                 2235             


Asp Ile  Pro Glu Gly Val Pro  Ala Pro Lys Ala His  Ser Tyr Ser 
    2240                 2245                 2250             


Pro Asp  Ser Phe Asn Val Ser  Trp Thr Glu Pro Glu  Tyr Pro Asn 
    2255                 2260                 2265             


Gly Val  Ile Thr Ser Tyr Gly  Leu Tyr Leu Asp Gly  Ile Leu Ile 
    2270                 2275                 2280             


His Asn  Ser Ser Glu Leu Ser  Tyr Arg Ala Tyr Gly  Phe Ala Pro 
    2285                 2290                 2295             


Trp Ser  Leu His Ser Phe Arg  Val Gln Ala Cys Thr  Ala Lys Gly 
    2300                 2305                 2310             


Cys Ala  Leu Gly Pro Leu Val  Glu Asn Arg Thr Leu  Glu Ala Pro 
    2315                 2320                 2325             


Pro Glu  Gly Thr Val Asn Val  Phe Val Lys Thr Gln  Gly Ser Arg 
    2330                 2335                 2340             


Lys Ala  His Val Arg Trp Glu  Ala Pro Phe Arg Pro  Asn Gly Leu 
    2345                 2350                 2355             


Leu Thr  His Ser Val Leu Phe  Thr Gly Ile Phe Tyr  Val Asp Pro 
    2360                 2365                 2370             


Val Gly  Asn Asn Tyr Thr Leu  Leu Asn Val Thr Lys  Val Met Tyr 
    2375                 2380                 2385             


Ser Gly  Glu Glu Thr Asn Leu  Trp Val Leu Ile Asp  Gly Leu Val 
    2390                 2395                 2400             


Pro Phe  Thr Asn Tyr Thr Val  Gln Val Asn Ile Ser  Asn Ser Gln 
    2405                 2410                 2415             


Gly Ser  Leu Ile Thr Asp Pro  Ile Thr Ile Ala Met  Pro Pro Gly 
    2420                 2425                 2430             


Ala Pro  Asp Gly Val Leu Pro  Pro Arg Leu Ser Ser  Ala Thr Pro 
    2435                 2440                 2445             


Thr Ser  Leu Gln Val Val Trp  Ser Thr Pro Ala Arg  Asn Asn Ala 
    2450                 2455                 2460             


Pro Gly  Ser Pro Arg Tyr Gln  Leu Gln Met Arg Ser  Gly Asp Ser 
    2465                 2470                 2475             


Thr His  Gly Phe Leu Glu Leu  Phe Ser Asn Pro Ser  Ala Ser Leu 
    2480                 2485                 2490             


Ser Tyr  Glu Val Ser Asp Leu  Gln Pro Tyr Thr Glu  Tyr Met Phe 
    2495                 2500                 2505             


Arg Leu  Val Ala Ser Asn Gly  Phe Gly Ser Ala His  Ser Ser Trp 
    2510                 2515                 2520             


Ile Pro  Phe Met Thr Ala Glu  Asp Lys Pro Gly Pro  Val Val Pro 
    2525                 2530                 2535             


Pro Ile  Leu Leu Asp Val Lys  Ser Arg Met Met Leu  Val Thr Trp 
    2540                 2545                 2550             


Gln His  Pro Arg Lys Ser Asn  Gly Val Ile Thr His  Tyr Asn Ile 
    2555                 2560                 2565             


Tyr Leu  His Gly Arg Leu Tyr  Leu Arg Thr Pro Gly  Asn Val Thr 
    2570                 2575                 2580             


Asn Cys  Thr Val Met His Leu  His Pro Tyr Thr Ala  Tyr Lys Phe 
    2585                 2590                 2595             


Gln Val  Glu Ala Cys Thr Ser  Lys Gly Cys Ser Leu  Ser Pro Glu 
    2600                 2605                 2610             


Ser Gln  Thr Val Trp Thr Leu  Pro Gly Ala Pro Glu  Gly Ile Pro 
    2615                 2620                 2625             


Ser Pro  Glu Leu Phe Ser Asp  Thr Pro Thr Ser Val  Ile Ile Ser 
    2630                 2635                 2640             


Trp Gln  Pro Pro Thr His Pro  Asn Gly Leu Val Glu  Asn Phe Thr 
    2645                 2650                 2655             


Ile Glu  Arg Arg Val Lys Gly  Lys Glu Glu Val Thr  Thr Leu Val 
    2660                 2665                 2670             


Thr Leu  Pro Arg Ser His Ser  Met Arg Phe Ile Asp  Lys Thr Ser 
    2675                 2680                 2685             


Ala Leu  Ser Pro Trp Thr Lys  Tyr Glu Tyr Arg Val  Leu Met Ser 
    2690                 2695                 2700             


Thr Leu  His Gly Gly Thr Asn  Ser Ser Ala Trp Val  Glu Val Thr 
    2705                 2710                 2715             


Thr Arg  Pro Ser Arg Pro Ala  Gly Val Gln Pro Pro  Val Val Thr 
    2720                 2725                 2730             


Val Leu  Glu Pro Asp Ala Val  Gln Val Thr Trp Lys  Pro Pro Leu 
    2735                 2740                 2745             


Ile Gln  Asn Gly Asp Ile Leu  Ser Tyr Glu Ile His  Met Pro Asp 
    2750                 2755                 2760             


Pro His  Ile Thr Leu Thr Asn  Val Thr Ser Ala Val  Leu Ser Gln 
    2765                 2770                 2775             


Lys Val  Thr His Leu Ile Pro  Phe Thr Asn Tyr Ser  Val Thr Ile 
    2780                 2785                 2790             


Val Ala  Cys Ser Gly Gly Asn  Gly Tyr Leu Gly Gly  Cys Thr Glu 
    2795                 2800                 2805             


Ser Leu  Pro Thr Tyr Val Thr  Thr His Pro Thr Val  Pro Gln Asn 
    2810                 2815                 2820             


Val Gly  Pro Leu Ser Val Ile  Pro Leu Ser Glu Ser  Tyr Val Val 
    2825                 2830                 2835             


Ile Ser  Trp Gln Pro Pro Ser  Lys Pro Asn Gly Pro  Asn Leu Arg 
    2840                 2845                 2850             


Tyr Glu  Leu Leu Arg Arg Lys  Ile Gln Gln Pro Leu  Ala Ser Asn 
    2855                 2860                 2865             


Pro Pro  Glu Asp Leu Asn Arg  Trp His Asn Ile Tyr  Ser Gly Thr 
    2870                 2875                 2880             


Gln Trp  Leu Tyr Glu Asp Lys  Gly Leu Ser Arg Phe  Thr Thr Tyr 
    2885                 2890                 2895             


Glu Tyr  Met Leu Phe Val His  Asn Ser Val Gly Phe  Thr Pro Ser 
    2900                 2905                 2910             


Arg Glu  Val Thr Val Thr Thr  Leu Ala Gly Leu Pro  Glu Arg Gly 
    2915                 2920                 2925             


Ala Asn  Leu Thr Ala Ser Val  Leu Asn His Thr Ala  Ile Asp Val 
    2930                 2935                 2940             


Arg Trp  Ala Lys Pro Thr Val  Gln Asp Leu Gln Gly  Glu Val Glu 
    2945                 2950                 2955             


Tyr Tyr  Thr Leu Phe Trp Ser  Ser Ala Thr Ser Asn  Asp Ser Leu 
    2960                 2965                 2970             


Lys Ile  Leu Pro Asp Val Asn  Ser His Val Ile Gly  His Leu Lys 
    2975                 2980                 2985             


Pro Asn  Thr Glu Tyr Trp Ile  Phe Ile Ser Val Phe  Asn Gly Val 
    2990                 2995                 3000             


His Ser  Ile Asn Ser Ala Gly  Leu His Ala Thr Thr  Cys Asp Gly 
    3005                 3010                 3015             


Glu Pro  Gln Gly Met Leu Pro  Pro Glu Val Val Ile  Ile Asn Ser 
    3020                 3025                 3030             


Thr Ala  Val Arg Val Ile Trp  Thr Ser Pro Ser Asn  Pro Asn Gly 
    3035                 3040                 3045             


Val Val  Thr Glu Tyr Ser Ile  Tyr Val Asn Asn Lys  Leu Tyr Lys 
    3050                 3055                 3060             


Thr Gly  Met Asn Val Pro Gly  Ser Phe Ile Leu Arg  Asp Leu Ser 
    3065                 3070                 3075             


Pro Phe  Thr Ile Tyr Asp Ile  Gln Val Glu Val Cys  Thr Ile Tyr 
    3080                 3085                 3090             


Ala Cys  Val Lys Ser Asn Gly  Thr Gln Ile Thr Thr  Val Glu Asp 
    3095                 3100                 3105             


Thr Pro  Ser Asp Ile Pro Thr  Pro Thr Ile Arg Gly  Ile Thr Ser 
    3110                 3115                 3120             


Arg Ser  Leu Gln Ile Asp Trp  Val Ser Pro Arg Lys  Pro Asn Gly 
    3125                 3130                 3135             


Ile Ile  Leu Gly Tyr Asp Leu  Leu Trp Lys Thr Trp  Tyr Pro Cys 
    3140                 3145                 3150             


Ala Lys  Thr Gln Lys Leu Val  Gln Asp Gln Ser Asp  Glu Leu Cys 
    3155                 3160                 3165             


Lys Ala  Val Arg Cys Gln Lys  Pro Glu Ser Ile Cys  Gly His Ile 
    3170                 3175                 3180             


Cys Tyr  Ser Ser Glu Ala Lys  Val Cys Cys Asn Gly  Val Leu Tyr 
    3185                 3190                 3195             


Asn Pro  Lys Pro Gly His Arg  Cys Cys Glu Glu Lys  Tyr Ile Pro 
    3200                 3205                 3210             


Phe Val  Leu Asn Ser Thr Gly  Val Cys Cys Gly Gly  Arg Ile Gln 
    3215                 3220                 3225             


Glu Ala  Gln Pro Asn His Gln  Cys Cys Ser Gly Tyr  Tyr Ala Arg 
    3230                 3235                 3240             


Ile Leu  Pro Gly Glu Val Cys  Cys Pro Asp Glu Gln  His Asn Arg 
    3245                 3250                 3255             


Val Ser  Val Gly Ile Gly Asp  Ser Cys Cys Gly Arg  Met Pro Tyr 
    3260                 3265                 3270             


Ser Thr  Ser Gly Asn Gln Ile  Cys Cys Ala Gly Arg  Leu His Asp 
    3275                 3280                 3285             


Gly His  Gly Gln Lys Cys Cys  Gly Arg Gln Ile Val  Ser Asn Asp 
    3290                 3295                 3300             


Leu Glu  Cys Cys Gly Gly Glu  Glu Gly Val Val Tyr  Asn Arg Leu 
    3305                 3310                 3315             


Pro Gly  Met Phe Cys Cys Gly  Gln Asp Tyr Val Asn  Met Ser Asp 
    3320                 3325                 3330             


Thr Ile  Cys Cys Ser Ala Ser  Ser Gly Glu Ser Lys  Ala His Ile 
    3335                 3340                 3345             


Lys Lys  Asn Asp Pro Val Pro  Val Lys Cys Cys Glu  Thr Glu Leu 
    3350                 3355                 3360             


Ile Pro  Lys Ser Gln Lys Cys  Cys Asn Gly Val Gly  Tyr Asn Pro 
    3365                 3370                 3375             


Leu Lys  Tyr Val Cys Ser Asp  Lys Ile Ser Thr Gly  Met Met Met 
    3380                 3385                 3390             


Lys Glu  Thr Lys Glu Cys Arg  Ile Leu Cys Pro Ala  Ser Met Glu 
    3395                 3400                 3405             


Ala Thr  Glu His Cys Gly Arg  Cys Asp Phe Asn Phe  Thr Ser His 
    3410                 3415                 3420             


Ile Cys  Thr Val Ile Arg Gly  Ser His Asn Ser Thr  Gly Lys Ala 
    3425                 3430                 3435             


Ser Ile  Glu Glu Met Cys Ser  Ser Ala Glu Glu Thr  Ile His Thr 
    3440                 3445                 3450             


Gly Ser  Val Asn Thr Tyr Ser  Tyr Thr Asp Val Asn  Leu Lys Pro 
    3455                 3460                 3465             


Tyr Met  Thr Tyr Glu Tyr Arg  Ile Ser Ala Trp Asn  Ser Tyr Gly 
    3470                 3475                 3480             


Arg Gly  Leu Ser Lys Ala Val  Arg Ala Arg Thr Lys  Glu Asp Val 
    3485                 3490                 3495             


Pro Gln  Gly Val Ser Pro Pro  Thr Trp Thr Lys Ile  Asp Asn Leu 
    3500                 3505                 3510             


Glu Asp  Thr Ile Val Leu Asn  Trp Arg Lys Pro Ile  Gln Ser Asn 
    3515                 3520                 3525             


Gly Pro  Ile Ile Tyr Tyr Ile  Leu Leu Arg Asn Gly  Ile Glu Arg 
    3530                 3535                 3540             


Phe Arg  Gly Thr Ser Leu Ser  Phe Ser Asp Lys Glu  Gly Ile Gln 
    3545                 3550                 3555             


Pro Phe  Gln Glu Tyr Ser Tyr  Gln Leu Lys Ala Cys  Thr Val Ala 
    3560                 3565                 3570             


Gly Cys  Ala Thr Ser Ser Lys  Val Val Ala Ala Thr  Thr Gln Gly 
    3575                 3580                 3585             


Val Pro  Glu Ser Ile Leu Pro  Pro Ser Ile Thr Ala  Leu Ser Ala 
    3590                 3595                 3600             


Val Ala  Leu His Leu Ser Trp  Ser Val Pro Glu Lys  Ser Asn Gly 
    3605                 3610                 3615             


Val Ile  Lys Glu Tyr Gln Ile  Arg Gln Val Gly Lys  Gly Leu Ile 
    3620                 3625                 3630             


His Thr  Asp Thr Thr Asp Arg  Arg Gln His Thr Val  Thr Gly Leu 
    3635                 3640                 3645             


Gln Pro  Tyr Thr Asn Tyr Ser  Phe Thr Leu Thr Ala  Cys Thr Ser 
    3650                 3655                 3660             


Ala Gly  Cys Thr Ser Ser Glu  Pro Phe Leu Gly Gln  Thr Leu Gln 
    3665                 3670                 3675             


Ala Ala  Pro Glu Gly Val Trp  Val Thr Pro Arg His  Ile Ile Ile 
    3680                 3685                 3690             


Asn Ser  Thr Thr Val Glu Leu  Tyr Trp Ser Leu Pro  Glu Lys Pro 
    3695                 3700                 3705             


Asn Gly  Leu Val Ser Gln Tyr  Gln Leu Ser Arg Asn  Gly Asn Leu 
    3710                 3715                 3720             


Leu Phe  Leu Gly Gly Ser Glu  Glu Gln Asn Phe Thr  Asp Lys Asn 
    3725                 3730                 3735             


Leu Glu  Pro Asn Ser Arg Tyr  Thr Tyr Lys Leu Glu  Val Lys Thr 
    3740                 3745                 3750             


Gly Gly  Gly Ser Ser Ala Ser  Asp Asp Tyr Ile Val  Gln Thr Pro 
    3755                 3760                 3765             


Met Ser  Thr Pro Glu Glu Ile  Tyr Pro Pro Tyr Asn  Ile Thr Val 
    3770                 3775                 3780             


Ile Gly  Pro Tyr Ser Ile Phe  Val Ala Trp Ile Pro  Pro Gly Ile 
    3785                 3790                 3795             


Leu Ile  Pro Glu Ile Pro Val  Glu Tyr Asn Val Leu  Leu Asn Asp 
    3800                 3805                 3810             


Gly Ser  Val Thr Pro Leu Ala  Phe Ser Val Gly His  His Gln Ser 
    3815                 3820                 3825             


Thr Leu  Leu Glu Asn Leu Thr  Pro Phe Thr Gln Tyr  Glu Ile Arg 
    3830                 3835                 3840             


Ile Gln  Ala Cys Gln Asn Gly  Ser Cys Gly Val Ser  Ser Arg Met 
    3845                 3850                 3855             


Phe Val  Lys Thr Pro Glu Ala  Ala Pro Met Asp Leu  Asn Ser Pro 
    3860                 3865                 3870             


Val Leu  Lys Ala Leu Gly Ser  Ala Cys Ile Glu Ile  Lys Trp Met 
    3875                 3880                 3885             


Pro Pro  Glu Lys Pro Asn Gly  Ile Ile Ile Asn Tyr  Phe Ile Tyr 
    3890                 3895                 3900             


Arg Arg  Pro Ala Gly Ile Glu  Glu Glu Ser Val Leu  Phe Val Trp 
    3905                 3910                 3915             


Ser Glu  Gly Ala Leu Glu Phe  Met Asp Glu Gly Asp  Thr Leu Arg 
    3920                 3925                 3930             


Pro Phe  Thr Leu Tyr Glu Tyr  Arg Val Arg Ala Cys  Asn Ser Lys 
    3935                 3940                 3945             


Gly Ser  Val Glu Ser Leu Trp  Ser Leu Thr Gln Thr  Leu Glu Ala 
    3950                 3955                 3960             


Pro Pro  Gln Asp Phe Pro Ala  Pro Trp Ala Gln Ala  Thr Ser Ala 
    3965                 3970                 3975             


His Ser  Val Leu Leu Asn Trp  Thr Lys Pro Glu Ser  Pro Asn Gly 
    3980                 3985                 3990             


Ile Ile  Ser His Tyr Arg Val  
    3995                 4000 


<210>  7117
<211>  255
<212>  DNA
<213>  Homosapiens

<400>  7117
ttcagccacc agtagccaaa tcccttccca gttctttgct gctctcctgg aacccaccca     60

aaaaggcaaa tggtattata actcagtact gtttatacat ggatgggagg ctgatctatt    120

caggcagtga ggagaactac atagtcacag atcatgagta ctttgagggc aggaacttta    180

tctttcatct ttcatcctga agacatggat cagcatatgt gtatagtagg agaacaataa    240

atagttttca gaatg                                                     255


<210>  7118
<211>  33
<212>  PRT
<213>  Homosapiens

<400>  7118

Met Asp Gly Arg Leu Ile Tyr Ser Gly Ser Glu Glu Asn Tyr Ile Val 
1               5                   10                  15      


Thr Asp His Glu Tyr Phe Glu Gly Arg Asn Phe Ile Phe His Leu Ser 
            20                  25                  30          


Ser 
    


<210>  7119
<211>  461
<212>  DNA
<213>  Homosapiens

<400>  7119
gttgcaggtt tcaaatgtgc tttctgtgag aaagtcaaga aggtgccact cccagccaag     60

gataatccta atccctgact tcagcttctt gctatctaca ccatctgtaa aggttaccta    120

tccttagaca tgttagaaac catatcagta accatatgat atttaaaatc ttgagatcaa    180

ttgtgtcgag taaaacaaat taaatcatgc cagataaaaa ttatgaattt ttccataaaa    240

gcatcatctt caggaaggac ctcaggatcc ttcctgagga tggtataact tcgcgggagc    300

cctcccagaa agactcctgt gttatctcca ataacagtac taccattcag gatggcagag    360

gaacctagag aagaggagat gagaaataca ccttcaccag gatactctag ttttactagc    420

tcagcaaata ataaaatcct tcaccagcct ttgggatacc a                        461


<210>  7120
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  7120

Met Pro Asp Lys Asn Tyr Glu Phe Phe His Lys Ser Ile Ile Phe Arg 
1               5                   10                  15      


Lys Asp Leu Arg Ile Leu Pro Glu Asp Gly Ile Thr Ser Arg Glu Pro 
            20                  25                  30          


Ser Gln Lys Asp Ser Cys Val Ile Ser Asn Asn Ser Thr Thr Ile Gln 
        35                  40                  45              


Asp Gly Arg Gly Thr 
    50              


<210>  7121
<211>  280
<212>  DNA
<213>  Homosapiens

<400>  7121
ctcccagcca aggataatcc taatccctga cttcagcttc ttgctatcta caccatctgt     60

aaaggttacc tatccttaga catgttagga tccttcctga ggatggtata acttcgcggg    120

agccctccca gaaagactcc tgtgttatct ccaataacag tactaccatt caggatggca    180

gaggaaccta gagaagagga gatgagaaat acaccttcac caggatactc tagttttact    240

agctcagcaa ataataaaat ccttcaccag cctttgggat                          280


<210>  7122
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  7122

Met Ala Glu Glu Pro Arg Glu Glu Glu Met Arg Asn Thr Pro Ser Pro 
1               5                   10                  15      


Gly Tyr Ser Ser Phe Thr Ser Ser Ala Asn Asn Lys Ile Leu His Gln 
            20                  25                  30          


Pro Leu 
        


<210>  7123
<211>  391
<212>  DNA
<213>  Homosapiens

<400>  7123
cattttagcc attgacagat gtattttcaa accaaggcat gctctgtcag aagactacaa     60

aaatattact gcttcaggaa accatatcag taaccatatg atatttaaaa tcttgagatc    120

aattgtgtcg agtaaaacaa attaaatcat gccagataaa aattatgaat ttttccataa    180

aagcatcatc ttcaggaagg acctcaggat ccttcctgag gatggtataa cttcgcggga    240

gccctcccag aaagactcct gtgttatctc caataacagt actaccattc aggatggcag    300

aggaacctag agaagaggag atgagaaata caccttcacc aggatactct agttttacta    360

gctcagcaaa taataaaatc cttcaccagc c                                   391


<210>  7124
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  7124

Met Pro Asp Lys Asn Tyr Glu Phe Phe His Lys Ser Ile Ile Phe Arg 
1               5                   10                  15      


Lys Asp Leu Arg Ile Leu Pro Glu Asp Gly Ile Thr Ser Arg Glu Pro 
            20                  25                  30          


Ser Gln Lys Asp Ser Cys Val Ile Ser Asn Asn Ser Thr Thr Ile Gln 
        35                  40                  45              


Asp Gly Arg Gly Thr 
    50              


<210>  7125
<211>  342
<212>  DNA
<213>  Homosapiens

<400>  7125
ggtaatagtc cttcctttta tataaatgca caaatacatg catgtgtgtg tgtgcacata     60

tgcatttgaa gataagtatt tacctgctcc tgttgtacgt cctcgactcc aatcactata    120

tactgaacct ccttcatgcg aggctatcac tcgatacagg atccttcctg aggatggtat    180

aacttcgcgg gagccctccc agaaagactc ctgtgttatc tccaataaca gtactaccat    240

tcaggatggc agaggaacct agagaagagg agatgagaaa tacaccttca ccaggatact    300

ctagttttac tagctcagca aataataaaa tccttcacca gc                       342


<210>  7126
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  7126

Met His Lys Tyr Met His Val Cys Val Cys Thr Tyr Ala Phe Glu Asp 
1               5                   10                  15      


Lys Tyr Leu Pro Ala Pro Val Val Arg Pro Arg Leu Gln Ser Leu Tyr 
            20                  25                  30          


Thr Glu Pro Pro Ser Cys Glu Ala Ile Thr Arg Tyr Arg Ile Leu Pro 
        35                  40                  45              


Glu Asp Gly Ile Thr Ser Arg Glu Pro Ser Gln Lys Asp Ser Cys Val 
    50                  55                  60                  


Ile Ser Asn Asn Ser Thr Thr Ile Gln Asp Gly Arg Gly Thr 
65                  70                  75              


<210>  7127
<211>  386
<212>  DNA
<213>  Homosapiens

<400>  7127
catatcagta accatatgat atttaaaatc ttgagatcaa ttgtgtcgag taaaacaaat     60

taaatcatgc cagataaaaa ttatgaattt ttccataaaa gcatcatctt caggaaggac    120

ctcaggaggg tgttctgcca tcatcacgtt atgaaaagca tttgaaagaa atgctgactg    180

ttgttgttga caaggaggag gggatccttc ctgaggatgg tataacttcg cgggagccct    240

cccagaaaga ctcctgtgtt atctccaata acagtactac cattcaggat ggcagaggaa    300

cctagagaag aggagatgag aaatacacct tcaccaggat actctagttt tactagctca    360

gcaaataata aaatccttca ccagcc                                         386


<210>  7128
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  7128

Met Leu Thr Val Val Val Asp Lys Glu Glu Gly Ile Leu Pro Glu Asp 
1               5                   10                  15      


Gly Ile Thr Ser Arg Glu Pro Ser Gln Lys Asp Ser Cys Val Ile Ser 
            20                  25                  30          


Asn Asn Ser Thr Thr Ile Gln Asp Gly Arg Gly Thr 
        35                  40                  


<210>  7129
<211>  647
<212>  DNA
<213>  Homosapiens

<400>  7129
cttaaggggt caccagtgga agtaactaca actaatgatc atggcaaaca atatagtgat     60

ggaaaatggc atgaaataat tgctattagg catcaggctt ttggccaaat cactctggat    120

gggatatata caggttcctc tgccatcctg aatggtagta ctgttattgg agataacaca    180

ggagtctttc tgggagggct cccgcgaagt tataccatcc tcaggaagga tcctgagata    240

atccaaaaag gttttgtggg ctgtctcaag gatgtacatt ttatgaagaa ttacaatccg    300

tcagctattt gggaacctct ggattggcag agttctgaag aacaaatcaa cgtgtataac    360

agctgggagg gatgtcccgc ttcattaaat gagggagctc agttcctagg agcagggttc    420

ctggaacttc atccatatat gtttcatggt ggaatgaact ttgagatttc ctttaagttc    480

agaactgacc aattaaatgg attgcttctt ttcgtttata acaaagatgg acctgatttt    540

cttgctgtat gtgaattaat ttgattaaaa ttactttaaa atataggacc caactttaaa    600

ataaataaac catgtgttgg cattacactt aattggggtt tctttac                  647


<210>  7130
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  7130

Met Lys Asn Tyr Asn Pro Ser Ala Ile Trp Glu Pro Leu Asp Trp Gln 
1               5                   10                  15      


Ser Ser Glu Glu Gln Ile Asn Val Tyr Asn Ser Trp Glu Gly Cys Pro 
            20                  25                  30          


Ala Ser Leu Asn Glu Gly Ala Gln Phe Leu Gly Ala Gly Phe Leu Glu 
        35                  40                  45              


Leu His Pro Tyr Met Phe His Gly Gly Met Asn Phe Glu Ile Ser Phe 
    50                  55                  60                  


Lys Phe Arg Thr Asp Gln Leu Asn Gly Leu Leu Leu Phe Val Tyr Asn 
65                  70                  75                  80  


Lys Asp Gly Pro Asp Phe Leu Ala Val Cys Glu Leu Ile 
                85                  90              


<210>  7131
<211>  617
<212>  DNA
<213>  Homosapiens

<400>  7131
ataaacatct gtttctgcag atatgatggg tttgaaccag cactaaacat tataattgct     60

atcatttact atagctgatg gtgtggtgtt tacatgaatc attaagaggc ttgcagtaaa    120

taggtagtga gagctagtgc ctatttcttt gactttaatg gcacataaaa ttaattgctt    180

gaaaataatc tttcaaaata tatatttctt gatatctata aactcctgca gagataatcc    240

aaaaaggttt tgtgggctgt ctcaaggatg tacattttat gaagaattac aatccgtcag    300

ctatttggga acctctggat tggcagagtt ctgaagaaca aatcaacgtg tataacagct    360

gggagggatg tcccgcttca ttaaatgagg gagctcagtt cctaggagca gggttcctgg    420

aacttcatcc atatatgttt catggtggaa tgaactttga gatttccttt aagttcagaa    480

ctgaccaatt aaatggattg cttcttttcg tttataacaa agatggacct gattttcttg    540

ctgtatgtga attaatttga ttaaaattac tttaaaatat aggacccaac tttaaaataa    600

ataaaccatg tgttggc                                                   617


<210>  7132
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  7132

Met Lys Asn Tyr Asn Pro Ser Ala Ile Trp Glu Pro Leu Asp Trp Gln 
1               5                   10                  15      


Ser Ser Glu Glu Gln Ile Asn Val Tyr Asn Ser Trp Glu Gly Cys Pro 
            20                  25                  30          


Ala Ser Leu Asn Glu Gly Ala Gln Phe Leu Gly Ala Gly Phe Leu Glu 
        35                  40                  45              


Leu His Pro Tyr Met Phe His Gly Gly Met Asn Phe Glu Ile Ser Phe 
    50                  55                  60                  


Lys Phe Arg Thr Asp Gln Leu Asn Gly Leu Leu Leu Phe Val Tyr Asn 
65                  70                  75                  80  


Lys Asp Gly Pro Asp Phe Leu Ala Val Cys Glu Leu Ile 
                85                  90              


<210>  7133
<211>  6336
<212>  DNA
<213>  Homosapiens

<400>  7133
tctgagcttc aggtaaccaa gtgtttgctc tgcagaatac tttacctggg cacccaagtc     60

ttccttccag cattcctgct gctacagcct atttgctgag taaccagggg ttacagcagc    120

gttgccaggc aacgagggac agcggtcctg ttgaagagcc atttgtcaca ctgaggggac    180

tggttgaaat gcaataaaga aatgatacca gcagctactc atgtcttcgc cattgctaag    240

aacgtcgttg gtattacctt actctgagaa cgtgtctgca gtttccagaa aatggagtat    300

cgcaacatca cttaaagtac cctgcttcaa agtattgctg gcaagtggcg tgggcctgat    360

tatttattta gaaatgcttt atcaggagga gaatgctttt ttgtaaacat gaattgccca    420

gttctttcat tgggctctgg cttcttgttt caggtcattg aaatgttgat ctttgcctat    480

tttgcttcaa tatccttgac tgagtcacga ggtcttttcc caaggctgga gaacgtggga    540

gctttcaaga aagtttccat cgtgccaacc caagcagtat gtggactccc agaccgaagc    600

actttttgtc acagctctgc tgctgctgaa agtattcagt tctgtaccca gcggttttgt    660

attcaggatt gcccatacag atcttcacac cctacctaca ctgccctttt ctcagcaggc    720

ctcagtagct gcatcacacc agacaagaat gatctgcatc ctaacgccca tagcaattct    780

gcaagtttta tttttggaaa tcacaagagc tgcttttctt ctcctccttc tccaaagctg    840

atggcatcat ttaccttagc tgtatggctg aaacctgagc aacaaggtgt aatgtgtgtt    900

atagaaaaga cagtagatgg gcagattgtg ttcaaactta caatatctga gaaagagacc    960

atgttttatt atcgcacagt aaatggtttg caacctccaa taaaagtaat gacactgggg   1020

agaattcttg tgaagaaatg gattcatctt agtgtgcagg tgcatcagac aaaaatcagc   1080

ttctttatca atggcgtgga gaaggatcat acacctttca atgcaagaac tctaagtggt   1140

tcaattacag attttgcatc tggtactgtg caaataggac agagtttaaa tggtttagag   1200

cagtttgtcg gaagaatgca agattttcga ttataccaag tggcacttac aaacagagag   1260

attctggaag tcttctctgg agatcttctc agattgcatg cccaatcaca ttgccgttgc   1320

cctggcagcc acccgcgggt ccaccctttg gcacagcggt actgcattcc taatgatgca   1380

ggagacacag ctgataatag agtgtcacgg ttgaatcctg aagcccatcc tctctctttt   1440

gtcaatgata atgatgttgg tacttcatgg gtttcaaatg tgtttacaaa cattacacag   1500

cttaatcaag gagtgactat ttcagttgat ttggaaaatg gacagtatca ggtgttttat   1560

attatcattc agttctttag tccacaacca acggaaataa ggattcaaag gaagaaggaa   1620

aatagtttag attgggagga ctggcaatat tttgccagga attgtggtgc ttttggaatg   1680

aaaaacaatg gagatttgga aaaacctgat tctgtcaact gtcttcagct ttccaatttt   1740

actccatatt cccgtggcaa tgtcacattt agcatcctga cacctggacc aaattatcgt   1800

cctggataca ataacttcta taatacccca tctcttcaag agttcgtaaa agccacgcaa   1860

ataaggtttc attttcatgg gcagtactat acaactgaga ctgctgttaa cctcagacac   1920

agatattatg cagtggacga aatcaccatt agtgggagat gtcagtgcca tggtcatgcc   1980

gataactgcg acacaacaag ccagccatat agatgcctct gctcccagga gagcttcact   2040

gaaggacttc attgtgatcg ctgcttgcct ctttataatg acaagccttt ccgccaaggt   2100

gatcaagttt acgctttcaa ttgtaaacct tgtcaatgca acagccattc caaaagctgc   2160

cattacaaca tctctgtaga cccatttcct tttgagcact tcagaggggg aggaggagtt   2220

tgtgatgatt gtgagcataa cactacagga aggaactgtg agctgtgcaa ggattacttt   2280

ttccgacaag ttggtgcaga tccttcggcc atagatgttt gcaaaccctg tgactgtgat   2340

acagttggca ctagaaatgg tagcattctt tgtgatcaga ttggaggaca gtgtaattgt   2400

aagagacacg tgtctggcag gcagtgcaat cagtgccaga atggattcta caatctacaa   2460

gagttggatc ctgatggctg cagtccctgt aactgcaata cctctgggac agtggatgga   2520

gatattacct gtcaccaaaa ttcaggccag tgcaagtgca aagcaaacgt tattgggctt   2580

aggtgtgatc attgcaattt tggatttaaa tttctccgaa gctttaatga tgttggatgt   2640

gagccctgcc agtgtaacct ccatggctca gtgaacaaat tctgcaatcc tcactctggg   2700

cagtgtgagt gcaaaaaaga agccaaagga cttcagtgtg acacctgcag agaaaacttt   2760

tatgggttag atgtcaccaa ttgtaaggcc tgtgactgtg acacagctgg atccctccct   2820

gggactgtct gtaatgctaa gacagggcag tgcatctgca agcccaatgt tgaagggaga   2880

cagtgcaata aatgtttgga gggaaacttc tacctacggc aaaataattc tttcctctgt   2940

ctgccttgca actgtgataa gactgggaca ataaatggct ctctgctgtg taacaaatca   3000

acaggacaat gtccttgcaa attaggggta acaggtcttc gctgtaatca gtgtgagcct   3060

cacaggtaca atttgaccat tgacaatttt caacactgcc agatgtgtga gtgtgattcc   3120

ttggggacat tacctgggac catttgtgac ccaatcagtg gccagtgcct gtgtgtgcct   3180

aatcgtcaag gaagaaggtg taatcagtgt caaccaggtt tttatatttc tccaggcaat   3240

gccactggct gcctgccatg ctcatgccat acaactggtg cagttaatca catctgtaat   3300

agcctgactg gtcagtgtgt ttgccaagat gcttccattg ctgggcaacg ttgtgaccaa   3360

tgcaaagacc attactttgg atttgatcct cagactggaa gatgtcagcc ttgtaattgt   3420

catctctcag gagccttgaa tgaaacctgt cacttggtca caggccagtg tttctgtaaa   3480

caatttgtca ctggctcaaa gtgtgatgct tgtgttccca gtgcaagcca cttggatgtc   3540

aacaatctat tgggttgcag caaaactcca ttccagcaac ctccgcccag aggacaagtt   3600

caaagttctt ctgctatcaa tctctcctgg agtccacctg attctccaaa tgcccactgg   3660

cttacttaca gtttactcag ggatggtttt gaaatctaca caacagagga tcaataccca   3720

tacagtattc aatacttctt agacacagac ctgttaccat ataccaaata ttcctattac   3780

attgagacca ccaatgtgca tggttcaaca aggagtgtag ctgtcactta caagacaaaa   3840

ccaggggtcc cagagggaaa cttgacttta agttatatca ttcctattgg ctcagactct   3900

gtgacactta cctggacaac actctcaaat caatctggtc ccatagagaa atatattttg   3960

tcctgtgccc ctttggctgg tggtcagcca tgtgtttcct acgaaggtca tgaaacctca   4020

gctaccatct ggaatctggt tccatttgcc aagtacgatt tttctgtaca ggcgtgtact   4080

agcgggggct gtttacacag cttgcccatt acagtgacca cagcccaggc ccctccccaa   4140

agactaagtc cacctaagat gcagaaaatc agttctacag aacttcatgt agaatggtct   4200

ccaccagcgg aactaaatgg aataattata agatatgaac tatacatgag aagactgaga   4260

tctactaaag aaaccacatc tgaggaaagt cgagtttttc agagcagtgg ttggctcagt   4320

cctcattcat ttgtagaatc ggccaatgaa aatgcattaa aacctcctca aacaatgaca   4380

accatcactg gcttggagcc atacaccaag tatgagttca gagtcttagc tgtgaatatg   4440

gctggaagtg tgtcttctgc ctgggtctca gaaagaacgg gagaatcagc acctgtattc   4500

atgatccctc cttcagtctt tcccctctct tcgtactctc tcaatatctc ctgggagaag   4560

ccagcagata atgttacaag aggaaaagtt gtggggtatg acatcaatat gctttctgaa   4620

caatcacctc aacagtctat tcccatggcg ttttcacagc tgttgcacac tgctaaatcc   4680

caagaactat cttacactgt agaaggactg aaaccttata ggatatatga gtttactatt   4740

actctctgca attcagttgg ttgtgtgacc agtgcttcgg gagcaggaca aactttagca   4800

gcagcaccag cacaactgag gccacctctg gttaaaggaa tcaacagcac aacaatccat   4860

cttaggtggt ttccacctga agaactgaat ggaccctctc ctatatatca gctggaaagg   4920

agagagtcat ctctaccagc tctgatgacc acgatgatga aaggaatccg tttcatagga   4980

aatgggtatt gtaaatttcc cagctccact cacccagtca atacagactt cactggtaag   5040

tgtgtttgac attgctttat ttaggagaca cgaagctcca aaatgttttc tatattttca   5100

tatcccttta caatgaattt ttattatacc tacttagaga aatactaatt cagccctttg   5160

atagcttttg cctgattgtt tcagcatgtc catcttttta gaattctggg gaaaaaagtc   5220

aggtaagtga aggaaaggaa aaataaaaga tgaagatgaa gaagcagcct tattggatca   5280

aagtatgtgc tttgtatttg tctttttgtg aagtatgtgc caggacatgt ttcttgaaat   5340

attattcact gtgttctctg agcaaatgag tttgcaaaat gccctcatgc tattggagat   5400

tctcagtatg caccccgtta ctgaaactcc aaaaagcatt gtaagaaagc tattcaactt   5460

tgcttagcta atcatgccta acagatattt gatgtaatgt tttctttttc tttctcttgc   5520

tgtttccttc ttcttttttt cactgtgaca acttaatatc tcatgttcta tgaagaacat   5580

tgtggggaaa actaatccca gggaaaagat aacttctcta agccaggact atggtaaagc   5640

aagtgaggct cttgtttcgg tcacaaaatt taaaggcact aaaaaactca gtgttaatgt   5700

aaattttaat gcaatatttt taaaaatgaa aatcaatgtg aaagcactat aaaaatatta   5760

tcaaaagctt aaataaagac agattgaact ctgtaccagc acaatcctgc ctcactggcc   5820

ttaccctcct cctggcctta ctagtaccgc aatattttgg aagtcccatg acctctgtga   5880

cttacagctt ctaatagcat gatttcaata tagctgtaaa aaaactctac ttatggtaca   5940

ccatttttcc aatttttaaa aaaatttaca aagtataaga tatatattat tatgtaaact   6000

cataaagatg ttcatttaat catccatgag aaagtcattt tggagcaaat agctagtctt   6060

taaaatattg catatgtgaa gacaatgaaa tggaattcga gctataaaaa tttgtattgt   6120

tttattttta cttaaaatag taaatagttt gcttttcatt gagactggct gctgatgcac   6180

cttggtaatg aatcatgatt atattctaac tgagatatat tgagattaat gcatgattaa   6240

ctactctctc agtacatcaa aatcattgca gagtattaga aattgaacca ttgagctaaa   6300

aatgctcaac ttctgcttta tattcttaaa atggca                             6336


<210>  7134
<211>  1546
<212>  PRT
<213>  Homosapiens

<400>  7134

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              


Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  


Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  


Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      


Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         


Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             


Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 


Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 


Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     


Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         


Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             


Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 


Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 


Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     


Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         


Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             


Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 


Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 


Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     


Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         


Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             


Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 


Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 


Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     


Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         


Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             


Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 


Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val 
465                 470                 475                 480 


Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     


Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         


Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             


Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 


Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 


Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     


Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         


Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             


Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 


Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 


Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             


Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 


Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 


Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     


Arg Ser Phe Asn Asp Val Gly Cys Glu Pro Cys Gln Cys Asn Leu His 
            740                 745                 750         


Gly Ser Val Asn Lys Phe Cys Asn Pro His Ser Gly Gln Cys Glu Cys 
        755                 760                 765             


Lys Lys Glu Ala Lys Gly Leu Gln Cys Asp Thr Cys Arg Glu Asn Phe 
    770                 775                 780                 


Tyr Gly Leu Asp Val Thr Asn Cys Lys Ala Cys Asp Cys Asp Thr Ala 
785                 790                 795                 800 


Gly Ser Leu Pro Gly Thr Val Cys Asn Ala Lys Thr Gly Gln Cys Ile 
                805                 810                 815     


Cys Lys Pro Asn Val Glu Gly Arg Gln Cys Asn Lys Cys Leu Glu Gly 
            820                 825                 830         


Asn Phe Tyr Leu Arg Gln Asn Asn Ser Phe Leu Cys Leu Pro Cys Asn 
        835                 840                 845             


Cys Asp Lys Thr Gly Thr Ile Asn Gly Ser Leu Leu Cys Asn Lys Ser 
    850                 855                 860                 


Thr Gly Gln Cys Pro Cys Lys Leu Gly Val Thr Gly Leu Arg Cys Asn 
865                 870                 875                 880 


Gln Cys Glu Pro His Arg Tyr Asn Leu Thr Ile Asp Asn Phe Gln His 
                885                 890                 895     


Cys Gln Met Cys Glu Cys Asp Ser Leu Gly Thr Leu Pro Gly Thr Ile 
            900                 905                 910         


Cys Asp Pro Ile Ser Gly Gln Cys Leu Cys Val Pro Asn Arg Gln Gly 
        915                 920                 925             


Arg Arg Cys Asn Gln Cys Gln Pro Gly Phe Tyr Ile Ser Pro Gly Asn 
    930                 935                 940                 


Ala Thr Gly Cys Leu Pro Cys Ser Cys His Thr Thr Gly Ala Val Asn 
945                 950                 955                 960 


His Ile Cys Asn Ser Leu Thr Gly Gln Cys Val Cys Gln Asp Ala Ser 
                965                 970                 975     


Ile Ala Gly Gln Arg Cys Asp Gln Cys Lys Asp His Tyr Phe Gly Phe 
            980                 985                 990         


Asp Pro Gln Thr Gly Arg Cys Gln  Pro Cys Asn Cys His  Leu Ser Gly 
        995                 1000                 1005             


Ala Leu  Asn Glu Thr Cys His  Leu Val Thr Gly Gln  Cys Phe Cys 
    1010                 1015                 1020             


Lys Gln  Phe Val Thr Gly Ser  Lys Cys Asp Ala Cys  Val Pro Ser 
    1025                 1030                 1035             


Ala Ser  His Leu Asp Val Asn  Asn Leu Leu Gly Cys  Ser Lys Thr 
    1040                 1045                 1050             


Pro Phe  Gln Gln Pro Pro Pro  Arg Gly Gln Val Gln  Ser Ser Ser 
    1055                 1060                 1065             


Ala Ile  Asn Leu Ser Trp Ser  Pro Pro Asp Ser Pro  Asn Ala His 
    1070                 1075                 1080             


Trp Leu  Thr Tyr Ser Leu Leu  Arg Asp Gly Phe Glu  Ile Tyr Thr 
    1085                 1090                 1095             


Thr Glu  Asp Gln Tyr Pro Tyr  Ser Ile Gln Tyr Phe  Leu Asp Thr 
    1100                 1105                 1110             


Asp Leu  Leu Pro Tyr Thr Lys  Tyr Ser Tyr Tyr Ile  Glu Thr Thr 
    1115                 1120                 1125             


Asn Val  His Gly Ser Thr Arg  Ser Val Ala Val Thr  Tyr Lys Thr 
    1130                 1135                 1140             


Lys Pro  Gly Val Pro Glu Gly  Asn Leu Thr Leu Ser  Tyr Ile Ile 
    1145                 1150                 1155             


Pro Ile  Gly Ser Asp Ser Val  Thr Leu Thr Trp Thr  Thr Leu Ser 
    1160                 1165                 1170             


Asn Gln  Ser Gly Pro Ile Glu  Lys Tyr Ile Leu Ser  Cys Ala Pro 
    1175                 1180                 1185             


Leu Ala  Gly Gly Gln Pro Cys  Val Ser Tyr Glu Gly  His Glu Thr 
    1190                 1195                 1200             


Ser Ala  Thr Ile Trp Asn Leu  Val Pro Phe Ala Lys  Tyr Asp Phe 
    1205                 1210                 1215             


Ser Val  Gln Ala Cys Thr Ser  Gly Gly Cys Leu His  Ser Leu Pro 
    1220                 1225                 1230             


Ile Thr  Val Thr Thr Ala Gln  Ala Pro Pro Gln Arg  Leu Ser Pro 
    1235                 1240                 1245             


Pro Lys  Met Gln Lys Ile Ser  Ser Thr Glu Leu His  Val Glu Trp 
    1250                 1255                 1260             


Ser Pro  Pro Ala Glu Leu Asn  Gly Ile Ile Ile Arg  Tyr Glu Leu 
    1265                 1270                 1275             


Tyr Met  Arg Arg Leu Arg Ser  Thr Lys Glu Thr Thr  Ser Glu Glu 
    1280                 1285                 1290             


Ser Arg  Val Phe Gln Ser Ser  Gly Trp Leu Ser Pro  His Ser Phe 
    1295                 1300                 1305             


Val Glu  Ser Ala Asn Glu Asn  Ala Leu Lys Pro Pro  Gln Thr Met 
    1310                 1315                 1320             


Thr Thr  Ile Thr Gly Leu Glu  Pro Tyr Thr Lys Tyr  Glu Phe Arg 
    1325                 1330                 1335             


Val Leu  Ala Val Asn Met Ala  Gly Ser Val Ser Ser  Ala Trp Val 
    1340                 1345                 1350             


Ser Glu  Arg Thr Gly Glu Ser  Ala Pro Val Phe Met  Ile Pro Pro 
    1355                 1360                 1365             


Ser Val  Phe Pro Leu Ser Ser  Tyr Ser Leu Asn Ile  Ser Trp Glu 
    1370                 1375                 1380             


Lys Pro  Ala Asp Asn Val Thr  Arg Gly Lys Val Val  Gly Tyr Asp 
    1385                 1390                 1395             


Ile Asn  Met Leu Ser Glu Gln  Ser Pro Gln Gln Ser  Ile Pro Met 
    1400                 1405                 1410             


Ala Phe  Ser Gln Leu Leu His  Thr Ala Lys Ser Gln  Glu Leu Ser 
    1415                 1420                 1425             


Tyr Thr  Val Glu Gly Leu Lys  Pro Tyr Arg Ile Tyr  Glu Phe Thr 
    1430                 1435                 1440             


Ile Thr  Leu Cys Asn Ser Val  Gly Cys Val Thr Ser  Ala Ser Gly 
    1445                 1450                 1455             


Ala Gly  Gln Thr Leu Ala Ala  Ala Pro Ala Gln Leu  Arg Pro Pro 
    1460                 1465                 1470             


Leu Val  Lys Gly Ile Asn Ser  Thr Thr Ile His Leu  Arg Trp Phe 
    1475                 1480                 1485             


Pro Pro  Glu Glu Leu Asn Gly  Pro Ser Pro Ile Tyr  Gln Leu Glu 
    1490                 1495                 1500             


Arg Arg  Glu Ser Ser Leu Pro  Ala Leu Met Thr Thr  Met Met Lys 
    1505                 1510                 1515             


Gly Ile  Arg Phe Ile Gly Asn  Gly Tyr Cys Lys Phe  Pro Ser Ser 
    1520                 1525                 1530             


Thr His  Pro Val Asn Thr Asp  Phe Thr Gly Lys Cys  Val 
    1535                 1540                 1545     


<210>  7135
<211>  704
<212>  DNA
<213>  Homosapiens

<400>  7135
ctgaaagagt tcccccaata aacctcctgt actcagtcct ctaccaagag tctgcttccg     60

ggggaatttg ccctaagata gtcgtaacag gactggccct aggaaggaga ctctaaaatg    120

atattttgga gctccatcat ccacttgctg gtttacaatg atctcatcat agacagcaga    180

gaagagcatc tctctcagag gaggcactga acagccaaat acacagaaga acttgttcgg    240

ttgacatcct tccatcagct tctgctattg gccacctgga tgctggtaaa atgggcagag    300

aggtatatca gccacaactg taaactggag agaacaagag cctcctatcc tctaggattg    360

ctgaaaaagg atatagtctc taatctgact ttcatcagta atgaagatcg tttttatttt    420

taaatttgat ctgcctacta tgtctagtgc tcctttgatt ccaaactcaa ataggaacaa    480

caccaaaaaa cagtatgagt tactgtccac tccctaaacc tgcaacacta acagaagagt    540

gctatttcct ccaataactg ttcacttcct tcctatgaca cgtaagatac ctatgagcaa    600

cccagaaggg ggctacaata gagatactgt tagggctgat tatgtatgat tctcgaagcg    660

ctagcttgac ctctacctta aataaaacgt aaagatatac cttg                     704


<210>  7136
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  7136

Met Leu Val Lys Trp Ala Glu Arg Tyr Ile Ser His Asn Cys Lys Leu 
1               5                   10                  15      


Glu Arg Thr Arg Ala Ser Tyr Pro Leu Gly Leu Leu Lys Lys Asp Ile 
            20                  25                  30          


Val Ser Asn Leu Thr Phe Ile Ser Asn Glu Asp Arg Phe Tyr Phe 
        35                  40                  45          


<210>  7137
<211>  1063
<212>  DNA
<213>  Homosapiens

<400>  7137
actgtcaggt gacgcttccg gcgcagaaaa atggcagccg ccgctccgga ctcacgtgtg     60

agtgaggaag aaaacctgaa aaagacccca aagaagaaga tgaaaatggt aactggagcc    120

gtagcgtcgg tgctggaaga cgaggccaca gacacttctg atagtgaagg aagctgtgga    180

tcggaaaagg accactttta ttctgatgat gacgcaatag aagctgacag tgagggtgat    240

gctgagccct gtgacaaaga aaatgaaaat gatggagaat caagtgttgg gactaatatg    300

ggctgggcag atgctatggc taaagtcctc aacaagaaaa ctcctgaaag taaacctact    360

attctggtca aaaataagaa gctggaaaag gaaaaagaaa agttaaagca agaaagacta    420

gagaaaataa aacagcgtga taagaggctg gagtgggaaa tgatgtgcag agtaaagcca    480

gatgttgtcc aagacaaaga gacagagaga aatcttcaga gaattgcaac aaggggtgtg    540

gtgcaattat ttaatgctgt tcagaaacat caaaagaatg ttgatgaaaa ggttaaggaa    600

gctggaagtt ctatgagaaa gcgtgctaag ttgatatcaa ctgtttccaa gaaagatttc    660

atcagtgttt tgagagggat ggatggaagt acaaatgaga ctgcttcaag caggaagaaa    720

ccaaaagcca aacagactga agtgaaatca gaagaaggcc caggttggac gatcctacgt    780

gatgatttca tgatgggagc atctatgaaa gactgggaca aggaaagtga tgggccagat    840

gacagcagac cagaatctgc aagtgactct gatacataaa gcatcatagg aaatacaatt    900

gcagtcgttt tattttttct agaaaaatat gtcatcctct gatagttggg gaattataag    960

gataccattt gtaagaaagc caaaagactt ttgccagatt tcatatttcc ccttttcatg   1020

tacactttat atatacttca ttaaaattat attttaaacc ctt                     1063


<210>  7138
<211>  282
<212>  PRT
<213>  Homosapiens

<400>  7138

Met Ala Ala Ala Ala Pro Asp Ser Arg Val Ser Glu Glu Glu Asn Leu 
1               5                   10                  15      


Lys Lys Thr Pro Lys Lys Lys Met Lys Met Val Thr Gly Ala Val Ala 
            20                  25                  30          


Ser Val Leu Glu Asp Glu Ala Thr Asp Thr Ser Asp Ser Glu Gly Ser 
        35                  40                  45              


Cys Gly Ser Glu Lys Asp His Phe Tyr Ser Asp Asp Asp Ala Ile Glu 
    50                  55                  60                  


Ala Asp Ser Glu Gly Asp Ala Glu Pro Cys Asp Lys Glu Asn Glu Asn 
65                  70                  75                  80  


Asp Gly Glu Ser Ser Val Gly Thr Asn Met Gly Trp Ala Asp Ala Met 
                85                  90                  95      


Ala Lys Val Leu Asn Lys Lys Thr Pro Glu Ser Lys Pro Thr Ile Leu 
            100                 105                 110         


Val Lys Asn Lys Lys Leu Glu Lys Glu Lys Glu Lys Leu Lys Gln Glu 
        115                 120                 125             


Arg Leu Glu Lys Ile Lys Gln Arg Asp Lys Arg Leu Glu Trp Glu Met 
    130                 135                 140                 


Met Cys Arg Val Lys Pro Asp Val Val Gln Asp Lys Glu Thr Glu Arg 
145                 150                 155                 160 


Asn Leu Gln Arg Ile Ala Thr Arg Gly Val Val Gln Leu Phe Asn Ala 
                165                 170                 175     


Val Gln Lys His Gln Lys Asn Val Asp Glu Lys Val Lys Glu Ala Gly 
            180                 185                 190         


Ser Ser Met Arg Lys Arg Ala Lys Leu Ile Ser Thr Val Ser Lys Lys 
        195                 200                 205             


Asp Phe Ile Ser Val Leu Arg Gly Met Asp Gly Ser Thr Asn Glu Thr 
    210                 215                 220                 


Ala Ser Ser Arg Lys Lys Pro Lys Ala Lys Gln Thr Glu Val Lys Ser 
225                 230                 235                 240 


Glu Glu Gly Pro Gly Trp Thr Ile Leu Arg Asp Asp Phe Met Met Gly 
                245                 250                 255     


Ala Ser Met Lys Asp Trp Asp Lys Glu Ser Asp Gly Pro Asp Asp Ser 
            260                 265                 270         


Arg Pro Glu Ser Ala Ser Asp Ser Asp Thr 
        275                 280         


<210>  7139
<211>  1373
<212>  DNA
<213>  Homosapiens

<400>  7139
actgtcaggt gacgcttccg gcgcagaaaa atggcagccg ccgctccgga ctcacgtgtg     60

agtgaggaag aaaacctgaa aaagacccca aagaagaaga tgaaaatggt aactggagcc    120

gtagcgtcgg tgctggaaga cgaggccaca gacacttctg atagtgaagg aagctgtgga    180

tcggaaaagg accactttta ttctgatgat gacgcaatag aagctgacag tgagggtgat    240

gctgagccct gtgacaaaga aaatgaaaat gatggagaat caagtgttgg gactaatatg    300

ggctgggcag atgctatggc taaagtcctc aacaagaaaa ctcctgaaag taaacctact    360

attctggtca aaaataagaa gctggaaaag gaaaaagaaa agttaaagca agaaagacta    420

gagaaaataa aacagcgtga taagaggctg gagtgggaaa tgatgtgcag agtaaagcca    480

gatgttgtcc aagacaaaga gacagagaga aatcttcaga gaattgcaac aaggggtgtg    540

gtgcaattat ttaatgctgt tcagaaacat caaaagaatg ttgatgaaaa ggttaaggaa    600

gctggaagtt ctatgagaaa gcgtgctaag ttgatatcaa ctgtttccaa gaaagatttc    660

atcagtgttt tgagagggat ggatggaagt acaaatgaga ctgcttcaag caggaagaaa    720

ccaaaagcca aacagactga agtgaaatca gaagaaggcc caggttggac gatcctacgt    780

gatgatttca tgatgggagc atctatgaaa gactgggaca aggaaagtga tgggccagat    840

gacagcagac cagaatctgc aagtgactct gatacataaa gcatcatagg aaatacaatt    900

gcagtcgttt tattttttct agaaaaatat gtcatcctct gatagttggg gaattataag    960

gataccattt gtaagaaagc caaaagactt ttgccagatt tcatatttcc ccttttcatg   1020

tacactttat atatacttca ttaaaattat attttaaacc cttgtataat tttaagcatt   1080

gttcctcaga acatttgtaa aaggatatat ttctgcttga ccagcgagat gtgcattttg   1140

ccaggatcat attggtcatg tctattggtg tattatttca gtatcaccaa tgttttcaga   1200

aatacagtac taattcatca ttaaactctt tgaagttaat atttttctgc cttctaactt   1260

atagactcaa ctatgtatct gtagtttttg ggaatggttg gtgttttttg ctttgtgttg   1320

ggaagttatt gagaaaacct atataataaa atttaaaatt atagtttttc aga          1373


<210>  7140
<211>  282
<212>  PRT
<213>  Homosapiens

<400>  7140

Met Ala Ala Ala Ala Pro Asp Ser Arg Val Ser Glu Glu Glu Asn Leu 
1               5                   10                  15      


Lys Lys Thr Pro Lys Lys Lys Met Lys Met Val Thr Gly Ala Val Ala 
            20                  25                  30          


Ser Val Leu Glu Asp Glu Ala Thr Asp Thr Ser Asp Ser Glu Gly Ser 
        35                  40                  45              


Cys Gly Ser Glu Lys Asp His Phe Tyr Ser Asp Asp Asp Ala Ile Glu 
    50                  55                  60                  


Ala Asp Ser Glu Gly Asp Ala Glu Pro Cys Asp Lys Glu Asn Glu Asn 
65                  70                  75                  80  


Asp Gly Glu Ser Ser Val Gly Thr Asn Met Gly Trp Ala Asp Ala Met 
                85                  90                  95      


Ala Lys Val Leu Asn Lys Lys Thr Pro Glu Ser Lys Pro Thr Ile Leu 
            100                 105                 110         


Val Lys Asn Lys Lys Leu Glu Lys Glu Lys Glu Lys Leu Lys Gln Glu 
        115                 120                 125             


Arg Leu Glu Lys Ile Lys Gln Arg Asp Lys Arg Leu Glu Trp Glu Met 
    130                 135                 140                 


Met Cys Arg Val Lys Pro Asp Val Val Gln Asp Lys Glu Thr Glu Arg 
145                 150                 155                 160 


Asn Leu Gln Arg Ile Ala Thr Arg Gly Val Val Gln Leu Phe Asn Ala 
                165                 170                 175     


Val Gln Lys His Gln Lys Asn Val Asp Glu Lys Val Lys Glu Ala Gly 
            180                 185                 190         


Ser Ser Met Arg Lys Arg Ala Lys Leu Ile Ser Thr Val Ser Lys Lys 
        195                 200                 205             


Asp Phe Ile Ser Val Leu Arg Gly Met Asp Gly Ser Thr Asn Glu Thr 
    210                 215                 220                 


Ala Ser Ser Arg Lys Lys Pro Lys Ala Lys Gln Thr Glu Val Lys Ser 
225                 230                 235                 240 


Glu Glu Gly Pro Gly Trp Thr Ile Leu Arg Asp Asp Phe Met Met Gly 
                245                 250                 255     


Ala Ser Met Lys Asp Trp Asp Lys Glu Ser Asp Gly Pro Asp Asp Ser 
            260                 265                 270         


Arg Pro Glu Ser Ala Ser Asp Ser Asp Thr 
        275                 280         


<210>  7141
<211>  492
<212>  DNA
<213>  Homosapiens

<400>  7141
gtgtgagtga ggaagaaaac ctgaaaaaga ccccaaagaa gaagatgaaa atggtaactg     60

gagccgtagc gtcggtgctg gaagacgagg ccacagacac ttctgatagt gaaggaagct    120

gtggatcgga aaaggaccac ttttattctg atgatgacgc aatagaagct gacagtgagg    180

gtgatgctga gccctgtgac aaagaaaatg aaaatgatgg agaatcaagt gttgggacta    240

atatgggctg ggcagatgct atggctaaag tcctcaacaa gaaaactcct gaaagtaaac    300

ctactattct ggtcaaaaat aagaagctgg aaaaggaaaa agaaaagtta aagcaagaaa    360

gactagagaa aataaaacag gtatgttcca ccagttctct tgtagattag attgtttgtc    420

taggctagct cttatcttga ccgaactgtt tcttgcagtg tttgaccaat taacgttcca    480

gtttttaact tg                                                        492


<210>  7142
<211>  121
<212>  PRT
<213>  Homosapiens

<400>  7142

Met Lys Met Val Thr Gly Ala Val Ala Ser Val Leu Glu Asp Glu Ala 
1               5                   10                  15      


Thr Asp Thr Ser Asp Ser Glu Gly Ser Cys Gly Ser Glu Lys Asp His 
            20                  25                  30          


Phe Tyr Ser Asp Asp Asp Ala Ile Glu Ala Asp Ser Glu Gly Asp Ala 
        35                  40                  45              


Glu Pro Cys Asp Lys Glu Asn Glu Asn Asp Gly Glu Ser Ser Val Gly 
    50                  55                  60                  


Thr Asn Met Gly Trp Ala Asp Ala Met Ala Lys Val Leu Asn Lys Lys 
65                  70                  75                  80  


Thr Pro Glu Ser Lys Pro Thr Ile Leu Val Lys Asn Lys Lys Leu Glu 
                85                  90                  95      


Lys Glu Lys Glu Lys Leu Lys Gln Glu Arg Leu Glu Lys Ile Lys Gln 
            100                 105                 110         


Val Cys Ser Thr Ser Ser Leu Val Asp 
        115                 120     


<210>  7143
<211>  784
<212>  DNA
<213>  Homosapiens

<400>  7143
tgtcgcttca ccagctggaa acctctgtga ccagtggtgc ctttgcctgt tttgctcggt     60

cctatgggct cgttttgccc actcagcctg gcagtctgcg ctcggctcgt gctaccagcc    120

tggatcccat gcctgccaag agcgagggat gtatgagcga gagtggggtc ctgccactga    180

acacagccag gcatgccagc tgcggcaggg tccatagctc ccggcaatgg catgggcgcc    240

ggctacttgc gaggctgcag ctggaccagg tgtactgtaa gcagcttcca tggccgacac    300

cagggaacgt cgtggcgttc tggaagcttg gagatgccag taactgcaga gccctaaaga    360

ggtgtcacag ccctggctca gggagctcct aggtctgggc ttcccgaagg gctgcagctc    420

ttctctcctt cttctttcct tgtcacctgc aacgtgactg aagtgaaatc agaagaaggc    480

ccaggttgga cgatcctacg tgatgatttc atgatgggag catctatgaa agactgggac    540

aaggaaagtg atgggccaga tgacagcaga ccagaatctg caagtgactc tgatacataa    600

agcatcatag gaaatacaat tgcagtcgtt ttattttttc tagaaaaata tgtcatcctc    660

tgatagttgg ggaattataa ggataccatt tgtaagaaag ccaaaagact tttgccagat    720

ttcatatttc cccttttcat gtacacttta tatatacttc attaaaatta tattttaaac    780

cctt                                                                 784


<210>  7144
<211>  87
<212>  PRT
<213>  Homosapiens

<400>  7144

Met Pro Ala Lys Ser Glu Gly Cys Met Ser Glu Ser Gly Val Leu Pro 
1               5                   10                  15      


Leu Asn Thr Ala Arg His Ala Ser Cys Gly Arg Val His Ser Ser Arg 
            20                  25                  30          


Gln Trp His Gly Arg Arg Leu Leu Ala Arg Leu Gln Leu Asp Gln Val 
        35                  40                  45              


Tyr Cys Lys Gln Leu Pro Trp Pro Thr Pro Gly Asn Val Val Ala Phe 
    50                  55                  60                  


Trp Lys Leu Gly Asp Ala Ser Asn Cys Arg Ala Leu Lys Arg Cys His 
65                  70                  75                  80  


Ser Pro Gly Ser Gly Ser Ser 
                85          


<210>  7145
<211>  1091
<212>  DNA
<213>  Homosapiens

<400>  7145
tgtcgcttca ccagctggaa acctctgtga ccagtggtgc ctttgcctgt tttgctcggt     60

cctatgggct cgttttgccc actcagcctg gcagtctgcg ctcggctcgt gctaccagcc    120

tggatcccat gcctgccaag agcgagggat gtatgagcga gagtggggtc ctgccactga    180

acacagccag gcatgccagc tgcggcaggg tccatagctc ccggcaatgg catgggcgcc    240

ggctacttgc gaggctgcag ctggaccagg tgtactgtaa gcagcttcca tggccgacac    300

cagggaacgt cgtggcgttc tggaagcttg gagatgccag taactgcaga gccctaaaga    360

ggtgtcacag ccctggctca gggagctcct aggtctgggc ttcccgaagg gctgcagctc    420

ttctctcctt cttctttcct tgtcacctgc aacgtgactg aagtgaaatc agaagaaggc    480

ccaggttgga cgatcctacg tgatgatttc atgatgggag catctatgaa agactgggac    540

aaggaaagtg atgggccaga tgacagcaga ccagaatctg caagtgactc tgatacataa    600

agcatcatag gaaatacaat tgcagtcgtt ttattttttc tagaaaaata tgtcatcctc    660

tgatagttgg ggaattataa ggataccatt tgtaagaaag ccaaaagact tttgccagat    720

ttcatatttc cccttttcat gtacacttta tatatacttc attaaaatta tattttaaac    780

ccttgtataa ttttaagcat tgttcctcag aacatttgta aaaggatata tttctgcttg    840

accagcgaga tgtgcatttt gccaggatca tattggtcat gtctattggt gtattatttc    900

agtatcacca atgttttcag aaatacagta ctaattcatc attaaactct ttgaagttaa    960

tatttttctg ccttctaact tatagactca actatgtatc tgtagttttt gggaatggtt   1020

ggtgtttttt gctttgtgtt gggaagttat tgagaaaacc tatataataa aatttaaaat   1080

tatagttttt c                                                        1091


<210>  7146
<211>  87
<212>  PRT
<213>  Homosapiens

<400>  7146

Met Pro Ala Lys Ser Glu Gly Cys Met Ser Glu Ser Gly Val Leu Pro 
1               5                   10                  15      


Leu Asn Thr Ala Arg His Ala Ser Cys Gly Arg Val His Ser Ser Arg 
            20                  25                  30          


Gln Trp His Gly Arg Arg Leu Leu Ala Arg Leu Gln Leu Asp Gln Val 
        35                  40                  45              


Tyr Cys Lys Gln Leu Pro Trp Pro Thr Pro Gly Asn Val Val Ala Phe 
    50                  55                  60                  


Trp Lys Leu Gly Asp Ala Ser Asn Cys Arg Ala Leu Lys Arg Cys His 
65                  70                  75                  80  


Ser Pro Gly Ser Gly Ser Ser 
                85          


<210>  7147
<211>  1187
<212>  DNA
<213>  Homosapiens

<400>  7147
atgctctttc gggtcctcac ttccaaggtg acaaaaggaa caatgatcat gccaaaaagg     60

gtggcagcca catgtgtgcc caaggacagg gctattaaga atttctttat tcaaaacaca    120

gtagaggctg cagcaagtgt cttcaatgca tatgtgcttc ccgagctgta tgtgaagcta    180

cattattgtg tgagttgtgc cattcacagc aggaagcctg caagaactga acatctccac    240

ttctatttag acctgcagat gctggcacca aagctcatga ataaaactcc ccagccaggg    300

tgtcgcaagg gctgccgttg tgatccgcag ggggtgaacg caaccgcgac ggctgatcgt    360

ctgtggctgg gttggcgttt ggagcaagag aaggaggagc aggagaagga gggagctgga    420

ggctggaagc gtttgcaagc ggcggcggca gcaacgtgga gtaaccaagc ggttcgccag    480

ctgccagccc cgggaccttt tcatctcttc ccttttggcc ggaggagccg agttcagatc    540

cgccactccg cacccgagac tgacacactg aactccactt cctcctctta aatttatttc    600

tacttaatag ccactcgtct ctttttttcc ccatctcatt gctccaagaa tttttttctt    660

cttactcgcc aaagtcaggg ttccctctgc ccgtcccgta ttaatatttc cacttttgga    720

actactggcc ttttcttttt aaaggaattc aagcaggata cgtttttctg ttgggcattg    780

actagattgt ttgcaaaagt ttcgcatcaa aaacaacaac aacaaaaaac caaacaactc    840

tccttgatct atactttgag aattgttgat ttcttttttt tattctgact tttaaaaaca    900

actttttttt ccactttttt aaaaaatgca ctactgtgtg ctgagcgctt ttctgatcct    960

gcatctggtc acggtcgcgc tcagcctgtc tacctgcagc acactcgata tggaccagtt   1020

catgcgcaag aggatcgagg cgatccgcgg gcagatcctg agcaagctga agctcaccag   1080

tcccccagaa gactatcctg agcccgagga agtccccccg gaggtgattt ccatctacaa   1140

cagcaccagg gacttgctcc aggagaaggc gagccggagg gcggccg                 1187


<210>  7148
<211>  196
<212>  PRT
<213>  Homosapiens

<400>  7148

Met Leu Phe Arg Val Leu Thr Ser Lys Val Thr Lys Gly Thr Met Ile 
1               5                   10                  15      


Met Pro Lys Arg Val Ala Ala Thr Cys Val Pro Lys Asp Arg Ala Ile 
            20                  25                  30          


Lys Asn Phe Phe Ile Gln Asn Thr Val Glu Ala Ala Ala Ser Val Phe 
        35                  40                  45              


Asn Ala Tyr Val Leu Pro Glu Leu Tyr Val Lys Leu His Tyr Cys Val 
    50                  55                  60                  


Ser Cys Ala Ile His Ser Arg Lys Pro Ala Arg Thr Glu His Leu His 
65                  70                  75                  80  


Phe Tyr Leu Asp Leu Gln Met Leu Ala Pro Lys Leu Met Asn Lys Thr 
                85                  90                  95      


Pro Gln Pro Gly Cys Arg Lys Gly Cys Arg Cys Asp Pro Gln Gly Val 
            100                 105                 110         


Asn Ala Thr Ala Thr Ala Asp Arg Leu Trp Leu Gly Trp Arg Leu Glu 
        115                 120                 125             


Gln Glu Lys Glu Glu Gln Glu Lys Glu Gly Ala Gly Gly Trp Lys Arg 
    130                 135                 140                 


Leu Gln Ala Ala Ala Ala Ala Thr Trp Ser Asn Gln Ala Val Arg Gln 
145                 150                 155                 160 


Leu Pro Ala Pro Gly Pro Phe His Leu Phe Pro Phe Gly Arg Arg Ser 
                165                 170                 175     


Arg Val Gln Ile Arg His Ser Ala Pro Glu Thr Asp Thr Leu Asn Ser 
            180                 185                 190         


Thr Ser Ser Ser 
        195     


<210>  7149
<211>  557
<212>  DNA
<213>  Homosapiens

<400>  7149
cgcaggggct cccttggact cccacccttt cccaacctct gctggcttct ccccaacgtg     60

gaattgctcg cttagggagc ttctggagct ccgctcggag cgaaccttct gctgccagca    120

gataacatca cgatcttgcc ggggagggga gatttataag ttctctctga accacgtgtc    180

tgccttcaac aaagtgacgt gctaggatta cagtcagaag tcctctcgtt acttagacca    240

cgagctctcc ccgaaccgtt gagggagtgt ggaaatgagg accgctgtgg ttactcaaag    300

tcaacatttt catttcggca tgactctgca gccatactga ccagacagat gatttaaact    360

ggaaactctg ttgaatgtac tcccaaaccc aagatctcta tactgttctc tacttcagat    420

gttcctgagt tcagaaaagt cacaaagaac tttctatcac ttttggaatt tatacttcag    480

ttgtgtatgg ggcctaggtt attagtagag cactgaataa ataaaataat aatagctaac    540

atatactaca cttagta                                                   557


<210>  7150
<211>  67
<212>  PRT
<213>  Homosapiens

<400>  7150

Ala Gly Ala Pro Leu Asp Ser His Pro Phe Pro Thr Ser Ala Gly Phe 
1               5                   10                  15      


Ser Pro Thr Trp Asn Cys Ser Leu Arg Glu Leu Leu Glu Leu Arg Ser 
            20                  25                  30          


Glu Arg Thr Phe Cys Cys Gln Gln Ile Thr Ser Arg Ser Cys Arg Gly 
        35                  40                  45              


Gly Glu Ile Tyr Lys Phe Ser Leu Asn His Val Ser Ala Phe Asn Lys 
    50                  55                  60                  


Val Thr Cys 
65          


<210>  7151
<211>  5310
<212>  DNA
<213>  Homosapiens

<400>  7151
cagaaggttc gctccgagcg gagctccaga agctcctgac aagagaaaga cagattgaga     60

tagagataga aagagaaaga gagaaagaga cagcagagcg agagcgcaag tgaaagaggc    120

aggggagggg gatggagaat attagcctga cggtctaggg agtcatccag gaacaaactg    180

aggggctgcc cggctgcaga caggaggaga cagagaggat ctattttagg gtggcaagtg    240

cctacctacc ctaagcgagc aattccacgt tggggagaag ccagcagagg ttgggaaagg    300

gtgggagtcc aagggagccc ctgcgcaacc ccctcaggaa taaaactccc cagccagggt    360

gtcgcaaggg ctgccgttgt gatccgcagg gggtgaacgc aaccgcgacg gctgatcgtc    420

tgtggctggg ttggcgtttg gagcaagaga aggaggagca ggagaaggag ggagctggag    480

gctggaagcg tttgcaagcg gcggcggcag caacgtggag taaccaagcg ggtcagcgcg    540

cgcccgccag ggtgtaggcc acggagcgca gctcccagag caggatccgc gccgcctcag    600

cagcctctgc ggcccctgcg gcacccgacc gagtaccgag cgccctgcga agcgcaccct    660

cctccccgcg gtgcgctggg ctcgccccca gcgcgcgcac acgcacacac acacacacac    720

acacacacgc acgcacacac gtgtgcgctt ctctgctccg gagctgctgc tgctcctgct    780

ctcagcgccg cagtggaagg caggaccgaa ccgctccttc tttaaatata taaatttcag    840

cccaggtcag cctcggcggc ccccctcacc gcgctcccgg cgcccctccc gtcagttcgc    900

cagctgccag ccccgggacc ttttcatctc ttcccttttg gccggaggag ccgagttcag    960

atccgccact ccgcacccga gactgacaca ctgaactcca cttcctcctc ttaaatttat   1020

ttctacttaa tagccactcg tctctttttt tccccatctc attgctccaa gaattttttt   1080

cttcttactc gccaaagtca gggttccctc tgcccgtccc gtattaatat ttccactttt   1140

ggaactactg gccttttctt tttaaaggaa ttcaagcagg atacgttttt ctgttgggca   1200

ttgactagat tgtttgcaaa agtttcgcat caaaaacaac aacaacaaaa aaccaaacaa   1260

ctctccttga tctatacttt gagaattgtt gatttctttt ttttattctg acttttaaaa   1320

acaacttttt tttccacttt tttaaaaaat gcactactgt gtgctgagcg cttttctgat   1380

cctgcatctg gtcacggtcg cgctcagcct gtctacctgc agcacactcg atatggacca   1440

gttcatgcgc aagaggatcg aggcgatccg cgggcagatc ctgagcaagc tgaagctcac   1500

cagtccccca gaagactatc ctgagcccga ggaagtcccc ccggaggtga tttccatcta   1560

caacagcacc agggacttgc tccaggagaa ggcgagccgg agggcggccg cctgcgagcg   1620

cgagaggagc gacgaagagt actacgccaa ggaggtttac aaaatagaca tgccgccctt   1680

cttcccctcc gaaactgtct gcccagttgt tacaacaccc tctggctcag tgggcagctt   1740

gtgctccaga cagtcccagg tgctctgtgg gtaccttgat gccatcccgc ccactttcta   1800

cagaccctac ttcagaattg ttcgatttga cgtctcagca atggagaaga atgcttccaa   1860

tttggtgaaa gcagagttca gagtctttcg tttgcagaac ccaaaagcca gagtgcctga   1920

acaacggatt gagctatatc agattctcaa gtccaaagat ttaacatctc caacccagcg   1980

ctacatcgac agcaaagttg tgaaaacaag agcagaaggc gaatggctct ccttcgatgt   2040

aactgatgct gttcatgaat ggcttcacca taaagacagg aacctgggat ttaaaataag   2100

cttacactgt ccctgctgca cttttgtacc atctaataat tacatcatcc caaataaaag   2160

tgaagaacta gaagcaagat ttgcaggtat tgatggcacc tccacatata ccagtggtga   2220

tcagaaaact ataaagtcca ctaggaaaaa aaacagtggg aagaccccac atctcctgct   2280

aatgttattg ccctcctaca gacttgagtc acaacagacc aaccggcgga agaagcgtgc   2340

tttggatgcg gcctattgct ttagaaatgt gcaggataat tgctgcctac gtccacttta   2400

cattgatttc aagagggatc tagggtggaa atggatacac gaacccaaag ggtacaatgc   2460

caacttctgt gctggagcat gcccgtattt atggagttca gacactcagc acagcagggt   2520

cctgagctta tataatacca taaatccaga agcatctgct tctccttgct gcgtgtccca   2580

agatttagaa cctctaacca ttctctacta cattggcaaa acacccaaga ttgaacagct   2640

ttctaatatg attgtaaagt cttgcaaatg cagctaaaat tcttggaaaa gtggcaagac   2700

caaaatgaca atgatgatga taatgatgat gacgacgaca acgatgatgc ttgtaacaag   2760

aaaacataag agagccttgg ttcatcagtg ttaaaaaatt tttgaaaagg cggtactagt   2820

tcagacactt tggaagtttg tgttctgttt gttaaaactg gcatctgaca caaaaaaagt   2880

tgaaggcctt attctacatt tcacctactt tgtaagtgag agagacaaga agcaaatttt   2940

ttttaaagaa aaaaataaac actggaagaa tttattagtg ttaattatgt gaacaacgac   3000

aacaacaaca acaacaacaa acaggaaaat cccattaagt ggagttgctg tacgtaccgt   3060

tcctatcccg cgcctcactt gatttttctg tattgctatg caataggcac ccttcccatt   3120

cttactctta gagttaacag tgagttattt attgtgtgtt actatataat gaacgtttca   3180

ttgcccttgg aaaataaaac aggtgtataa agtggagacc aaatactttg ccagaaactc   3240

atggatggct taaggaactt gaactcaaac gagccagaaa aaaagaggtc atattaatgg   3300

gatgaaaacc caagtgagtt attatatgac cgagaaagtc tgcattaaga taaagaccct   3360

gaaaacacat gttatgtatc agctgcctaa ggaagcttct tgtaaggtcc aaaaactaaa   3420

aagactgtta ataaaagaaa ctttcagtca gaataagtct gtaagttttt ttttttcttt   3480

ttaattgtaa atggttcttt gtcagtttag taaaccagtg aaatgttgaa atgttttgac   3540

atgtactggt caaacttcag accttaaaat attgctgtat agctatgcta taggtttttt   3600

cctttgtttt ggtatatgta accataccta tattattaaa atagatggat atagaagcca   3660

gcataattga aaacacatct gcagatctct tttgcaaact attaaatcaa aacattaact   3720

actttatgtg taatgtgtaa atttttacca tattttttat attctgtaat aatgtcaact   3780

atgatttaga ttgacttaaa tttgggctct ttttaatgat cactcacaaa tgtatgtttc   3840

ttttagctgg ccagtacttt tgagtaaagc ccctatagtt tgacttgcac tacaaatgca   3900

tttttttttt aataacattt gccctacttg tgctttgtgt ttctttcatt attatgacat   3960

aagctacctg ggtccacttg tcttttcttt tttttgtttc acagaaaaga tgggttcgag   4020

ttcagtggtc ttcatcttcc aagcatcatt actaaccaag tcagacgtta acaaattttt   4080

atgttaggaa aaggaggaat gttatagata catagaaaat tgaagtaaaa tgttttcatt   4140

ttagcaagga tttagggttc taactaaaac tcagaatctt tattgagtta agaaaagttt   4200

ctctaccttg gtttaatcaa tatttttgta aaatcctatt gttattacaa agaggacact   4260

tcataggaaa catctttttc tttagtcagg tttttaatat tcagggggaa attgaaagat   4320

atatatttta gtcgattttt caaaagggga aaaaagtcca ggtcagcata agtcattttg   4380

tgtatttcac tgaagttata aggtttttat aaatgttctt tgaaggggaa aaggcacaag   4440

ccaatttttc ctatgatcaa aaaattcttt ctttcctctg agtgagagtt atctatatct   4500

gaggctaaag tttaccttgc tttaataaat aatttgccac atcattgcag aagaggtatc   4560

ctcatgctgg ggttaataga atatgtcagt ttatcacttg tcgcttattt agctttaaaa   4620

taaaaattaa taggcaaagc aatggaatat ttgcagtttc acctaaagag cagcataagg   4680

aggcgggaat ccaaagtgaa gttgtttgat atggtctact tcttttttgg aatttcctga   4740

ccattaatta aagaattgga tttgcaagtt tgaaaactgg aaaagcaaga gatgggatgc   4800

cataatagta aacagccctt gtgttggatg taacccaatc ccagatttga gtgtgtgttg   4860

attatttttt tgtcttccac ttttctatta tgtgtaaatc acttttattt ctgcagacat   4920

tttcctctca gataggatga cattttgttt tgtattattt tgtctttcct catgaatgca   4980

ctgataatat tttaaatgct ctattttaag atctcttgaa tctgtttttt ttttttttaa   5040

tttgggggtt ctgtaaggtc tttatttccc ataagtaaat attgccatgg gaggggggtg   5100

gaggtggcaa ggaaggggtg aagtgctagt atgcaagtgg gcagcaatta tttttgtgtt   5160

aatcagcagt acaatttgat cgttggcatg gttaaaaaat ggaatataag attagctgtt   5220

ttgtattttg atgaccaatt acgctgtatt ttaacacgat gtatgtctgt ttttgtggtg   5280

ctctagtggt aaataaatta tttcgatgat                                    5310


<210>  7152
<211>  442
<212>  PRT
<213>  Homosapiens

<400>  7152

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Thr Val Cys Pro Val Val Thr Thr Pro Ser Gly Ser Val 
        115                 120                 125             


Gly Ser Leu Cys Ser Arg Gln Ser Gln Val Leu Cys Gly Tyr Leu Asp 
    130                 135                 140                 


Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg Ile Val Arg Phe 
145                 150                 155                 160 


Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu Val Lys Ala Glu 
                165                 170                 175     


Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg Val Pro Glu Gln 
            180                 185                 190         


Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp Leu Thr Ser Pro 
        195                 200                 205             


Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr Arg Ala Glu Gly 
    210                 215                 220                 


Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His Glu Trp Leu His 
225                 230                 235                 240 


His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu His Cys Pro Cys 
                245                 250                 255     


Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn Lys Ser Glu 
            260                 265                 270         


Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser Thr Tyr Thr 
        275                 280                 285             


Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys Asn Ser Gly 
    290                 295                 300                 


Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr Arg Leu Glu 
305                 310                 315                 320 


Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp Ala Ala Tyr 
                325                 330                 335     


Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro Leu Tyr Ile 
            340                 345                 350         


Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly 
        355                 360                 365             


Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu Trp Ser Ser 
    370                 375                 380                 


Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr Ile Asn Pro 
385                 390                 395                 400 


Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu Glu Pro Leu 
                405                 410                 415     


Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu Gln Leu Ser 
            420                 425                 430         


Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
        435                 440         


<210>  7153
<211>  5934
<212>  DNA
<213>  Homosapiens

<400>  7153
cagaaggttc gctccgagcg gagctccaga agctcctgac aagagaaaga cagattgaga     60

tagagataga aagagaaaga gagaaagaga cagcagagcg agagcgcaag tgaaagaggc    120

aggggagggg gatggagaat attagcctga cggtctaggg agtcatccag gaacaaactg    180

aggggctgcc cggctgcaga caggaggaga cagagaggat ctattttagg gtggcaagtg    240

cctacctacc ctaagcgagc aattccacgt tggggagaag ccagcagagg ttgggaaagg    300

gtgggagtcc aagggagccc ctgcgcaacc ccctcaggaa taaaactccc cagccagggt    360

gtcgcaaggg ctgccgttgt gatccgcagg gggtgaacgc aaccgcgacg gctgatcgtc    420

tgtggctggg ttggcgtttg gagcaagaga aggaggagca ggagaaggag ggagctggag    480

gctggaagcg tttgcaagcg gcggcggcag caacgtggag taaccaagcg ggtcagcgcg    540

cgcccgccag ggtgtaggcc acggagcgca gctcccagag caggatccgc gccgcctcag    600

cagcctctgc ggcccctgcg gcacccgacc gagtaccgag cgccctgcga agcgcaccct    660

cctccccgcg gtgcgctggg ctcgccccca gcgcgcgcac acgcacacac acacacacac    720

acacacacgc acgcacacac gtgtgcgctt ctctgctccg gagctgctgc tgctcctgct    780

ctcagcgccg cagtggaagg caggaccgaa ccgctccttc tttaaatata taaatttcag    840

cccaggtcag cctcggcggc ccccctcacc gcgctcccgg cgcccctccc gtcagttcgc    900

cagctgccag ccccgggacc ttttcatctc ttcccttttg gccggaggag ccgagttcag    960

atccgccact ccgcacccga gactgacaca ctgaactcca cttcctcctc ttaaatttat   1020

ttctacttaa tagccactcg tctctttttt tccccatctc attgctccaa gaattttttt   1080

cttcttactc gccaaagtca gggttccctc tgcccgtccc gtattaatat ttccactttt   1140

ggaactactg gccttttctt tttaaaggaa ttcaagcagg atacgttttt ctgttgggca   1200

ttgactagat tgtttgcaaa agtttcgcat caaaaacaac aacaacaaaa aaccaaacaa   1260

ctctccttga tctatacttt gagaattgtt gatttctttt ttttattctg acttttaaaa   1320

acaacttttt tttccacttt tttaaaaaat gcactactgt gtgctgagcg cttttctgat   1380

cctgcatctg gtcacggtcg cgctcagcct gtctacctgc agcacactcg atatggacca   1440

gttcatgcgc aagaggatcg aggcgatccg cgggcagatc ctgagcaagc tgaagctcac   1500

cagtccccca gaagactatc ctgagcccga ggaagtcccc ccggaggtga tttccatcta   1560

caacagcacc agggacttgc tccaggagaa ggcgagccgg agggcggccg cctgcgagcg   1620

cgagaggagc gacgaagagt actacgccaa ggaggtttac aaaatagaca tgccgccctt   1680

cttcccctcc gaaactgtct gcccagttgt tacaacaccc tctggctcag tgggcagctt   1740

gtgctccaga cagtcccagg tgctctgtgg gtaccttgat gccatcccgc ccactttcta   1800

cagaccctac ttcagaattg ttcgatttga cgtctcagca atggagaaga atgcttccaa   1860

tttggtgaaa gcagagttca gagtctttcg tttgcagaac ccaaaagcca gagtgcctga   1920

acaacggatt gagctatatc agattctcaa gtccaaagat ttaacatctc caacccagcg   1980

ctacatcgac agcaaagttg tgaaaacaag agcagaaggc gaatggctct ccttcgatgt   2040

aactgatgct gttcatgaat ggcttcacca taaagacagg aacctgggat ttaaaataag   2100

cttacactgt ccctgctgca cttttgtacc atctaataat tacatcatcc caaataaaag   2160

tgaagaacta gaagcaagat ttgcaggtat tgatggcacc tccacatata ccagtggtga   2220

tcagaaaact ataaagtcca ctaggaaaaa aaacagtggg aagaccccac atctcctgct   2280

aatgttattg ccctcctaca gacttgagtc acaacagacc aaccggcgga agaagcgtgc   2340

tttggatgcg gcctattgct ttagaaatgt gcaggataat tgctgcctac gtccacttta   2400

cattgatttc aagagggatc tagggtggaa atggatacac gaacccaaag ggtacaatgc   2460

caacttctgt gctggagcat gcccgtattt atggagttca gacactcagc acagcagggt   2520

cctgagctta tataatacca taaatccaga agcatctgct tctccttgct gcgtgtccca   2580

agatttagaa cctctaacca ttctctacta cattggcaaa acacccaaga ttgaacagct   2640

ttctaatatg attgtaaagt cttgcaaatg cagctaaaat tcttggaaaa gtggcaagac   2700

caaaatgaca atgatgatga taatgatgat gacgacgaca acgatgatgc ttgtaacaag   2760

aaaacataag agagccttgg ttcatcagtg ttaaaaaatt tttgaaaagg cggtactagt   2820

tcagacactt tggaagtttg tgttctgttt gttaaaactg gcatctgaca caaaaaaagt   2880

tgaaggcctt attctacatt tcacctactt tgtaagtgag agagacaaga agcaaatttt   2940

ttttaaagaa aaaaataaac actggaagaa tttattagtg ttaattatgt gaacaacgac   3000

aacaacaaca acaacaacaa acaggaaaat cccattaagt ggagttgctg tacgtaccgt   3060

tcctatcccg cgcctcactt gatttttctg tattgctatg caataggcac ccttcccatt   3120

cttactctta gagttaacag tgagttattt attgtgtgtt actatataat gaacgtttca   3180

ttgcccttgg aaaataaaac aggtgtataa agtggagacc aaatactttg ccagaaactc   3240

atggatggct taaggaactt gaactcaaac gagccagaaa aaaagaggtc atattaatgg   3300

gatgaaaacc caagtgagtt attatatgac cgagaaagtc tgcattaaga taaagaccct   3360

gaaaacacat gttatgtatc agctgcctaa ggaagcttct tgtaaggtcc aaaaactaaa   3420

aagactgtta ataaaagaaa ctttcagtca gaataagtct gtaagttttt ttttttcttt   3480

ttaattgtaa atggttcttt gtcagtttag taaaccagtg aaatgttgaa atgttttgac   3540

atgtactggt caaacttcag accttaaaat attgctgtat agctatgcta taggtttttt   3600

cctttgtttt ggtatatgta accataccta tattattaaa atagatggat atagaagcca   3660

gcataattga aaacacatct gcagatctct tttgcaaact attaaatcaa aacattaact   3720

actttatgtg taatgtgtaa atttttacca tattttttat attctgtaat aatgtcaact   3780

atgatttaga ttgacttaaa tttgggctct ttttaatgat cactcacaaa tgtatgtttc   3840

ttttagctgg ccagtacttt tgagtaaagc ccctatagtt tgacttgcac tacaaatgca   3900

tttttttttt aataacattt gccctacttg tgctttgtgt ttctttcatt attatgacat   3960

aagctacctg ggtccacttg tcttttcttt tttttgtttc acagaaaaga tgggttcgag   4020

ttcagtggtc ttcatcttcc aagcatcatt actaaccaag tcagacgtta acaaattttt   4080

atgttaggaa aaggaggaat gttatagata catagaaaat tgaagtaaaa tgttttcatt   4140

ttagcaagga tttagggttc taactaaaac tcagaatctt tattgagtta agaaaagttt   4200

ctctaccttg gtttaatcaa tatttttgta aaatcctatt gttattacaa agaggacact   4260

tcataggaaa catctttttc tttagtcagg tttttaatat tcagggggaa attgaaagat   4320

atatatttta gtcgattttt caaaagggga aaaaagtcca ggtcagcata agtcattttg   4380

tgtatttcac tgaagttata aggtttttat aaatgttctt tgaaggggaa aaggcacaag   4440

ccaatttttc ctatgatcaa aaaattcttt ctttcctctg agtgagagtt atctatatct   4500

gaggctaaag tttaccttgc tttaataaat aatttgccac atcattgcag aagaggtatc   4560

ctcatgctgg ggttaataga atatgtcagt ttatcacttg tcgcttattt agctttaaaa   4620

taaaaattaa taggcaaagc aatggaatat ttgcagtttc acctaaagag cagcataagg   4680

aggcgggaat ccaaagtgaa gttgtttgat atggtctact tcttttttgg aatttcctga   4740

ccattaatta aagaattgga tttgcaagtt tgaaaactgg aaaagcaaga gatgggatgc   4800

cataatagta aacagccctt gtgttggatg taacccaatc ccagatttga gtgtgtgttg   4860

attatttttt tgtcttccac ttttctatta tgtgtaaatc acttttattt ctgcagacat   4920

tttcctctca gataggatga cattttgttt tgtattattt tgtctttcct catgaatgca   4980

ctgataatat tttaaatgct ctattttaag atctcttgaa tctgtttttt ttttttttaa   5040

tttgggggtt ctgtaaggtc tttatttccc ataagtaaat attgccatgg gaggggggtg   5100

gaggtggcaa ggaaggggtg aagtgctagt atgcaagtgg gcagcaatta tttttgtgtt   5160

aatcagcagt acaatttgat cgttggcatg gttaaaaaat ggaatataag attagctgtt   5220

ttgtattttg atgaccaatt acgctgtatt ttaacacgat gtatgtctgt ttttgtggtg   5280

ctctagtggt aaataaatta tttcgatgat atgtggatgt ctttttccta tcagtaccat   5340

catcgagtct agaaaacacc tgtgatgcaa taagactatc tcaagctgga aaagtcatac   5400

cacctttccg attgccctct gtgctttctc ccttaaggac agtcacttca gaagtcatgc   5460

tttaaagcac aagagtcagg ccatatccat caaggataga agaaatccct gtgccgtctt   5520

tttattccct tatttattgc tatttggtaa ttgtttgaga tttagtttcc atccagcttg   5580

actgccgacc agaaaaaatg cagagagatg tttgcaccat gctttggctt tctggttcta   5640

tgttctgcca acgccagggc caaaagaact ggtctagaca gtatcccctg tagccccata   5700

acttggatag ttgctgagcc agccagatat aacaagagcc acgtgctttc tggggttggt   5760

tgtttgggat cagctacttg cctgtcagtt tcactggtac cactgcacca caaacaaaaa   5820

aacccaccct atttcctcca atttttttgg ctgctaccta caagaccaga ctcctcaaac   5880

gagttgccaa tctcttaata aataggatta ataaaaaaag taattgtgac tcaa         5934


<210>  7154
<211>  442
<212>  PRT
<213>  Homosapiens

<400>  7154

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Thr Val Cys Pro Val Val Thr Thr Pro Ser Gly Ser Val 
        115                 120                 125             


Gly Ser Leu Cys Ser Arg Gln Ser Gln Val Leu Cys Gly Tyr Leu Asp 
    130                 135                 140                 


Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg Ile Val Arg Phe 
145                 150                 155                 160 


Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu Val Lys Ala Glu 
                165                 170                 175     


Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg Val Pro Glu Gln 
            180                 185                 190         


Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp Leu Thr Ser Pro 
        195                 200                 205             


Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr Arg Ala Glu Gly 
    210                 215                 220                 


Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His Glu Trp Leu His 
225                 230                 235                 240 


His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu His Cys Pro Cys 
                245                 250                 255     


Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn Lys Ser Glu 
            260                 265                 270         


Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser Thr Tyr Thr 
        275                 280                 285             


Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys Asn Ser Gly 
    290                 295                 300                 


Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr Arg Leu Glu 
305                 310                 315                 320 


Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp Ala Ala Tyr 
                325                 330                 335     


Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro Leu Tyr Ile 
            340                 345                 350         


Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly 
        355                 360                 365             


Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu Trp Ser Ser 
    370                 375                 380                 


Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr Ile Asn Pro 
385                 390                 395                 400 


Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu Glu Pro Leu 
                405                 410                 415     


Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu Gln Leu Ser 
            420                 425                 430         


Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
        435                 440         


<210>  7155
<211>  4518
<212>  DNA
<213>  Homosapiens

<400>  7155
acacacacac acacacacac gcacgcacac acgtgtgcgc ttctctgctc cggagctgct     60

gctgctcctg ctctcagcgc cgcagtggaa ggcaggaccg aaccgctcct tctttaaata    120

tataaatttc agcccaggtc agcctcggcg gcccccctca ccgcgctccc ggcgcccctc    180

ccgtcagttc gccagctgcc agccccggga ccttttcatc tcttcccttt tggccggagg    240

agccgagttc agatccgcca ctccgcaccc gagactgaca cactgaactc cacttcctcc    300

tcttaaattt atttctactt aatagccact cgtctctttt tttccccatc tcattgctcc    360

aagaattttt ttcttcttac tcgccaaagt cagggttccc tctgcccgtc ccgtattaat    420

atttccactt ttggaactac tggccttttc tttttaaagg aattcaagca ggatacgttt    480

ttctgttggg cattgactag attgtttgca aaagtttcgc atcaaaaaca acaacaacaa    540

aaaaccaaac aactctcctt gatctatact ttgagaattg ttgatttctt ttttttattc    600

tgacttttaa aaacaacttt tttttccact tttttaaaaa atgcactact gtgtgctgag    660

cgcttttctg atcctgcatc tggtcacggt cgcgctcagc ctgtctacct gcagcacact    720

cgatatggac cagttcatgc gcaagaggat cgaggcgatc cgcgggcaga tcctgagcaa    780

gctgaagctc accagtcccc cagaagacta tcctgagccc gaggaagtcc ccccggaggt    840

gatttccatc tacaacagca ccagggactt gctccaggag aaggcgagcc ggagggcggc    900

cgcctgcgag cgcgagagga gcgacgaaga gtactacgcc aaggaggttt acaaaataga    960

catgccgccc ttcttcccct ccgaaaatgc catcccgccc actttctaca gaccctactt   1020

cagaattgtt cgatttgacg tctcagcaat ggagaagaat gcttccaatt tggtgaaagc   1080

agagttcaga gtctttcgtt tgcagaaccc aaaagccaga gtgcctgaac aacggattga   1140

gctatatcag attctcaagt ccaaagattt aacatctcca acccagcgct acatcgacag   1200

caaagttgtg aaaacaagag cagaaggcga atggctctcc ttcgatgtaa ctgatgctgt   1260

tcatgaatgg cttcaccata aagacaggaa cctgggattt aaaataagct tacactgtcc   1320

ctgctgcact tttgtaccat ctaataatta catcatccca aataaaagtg aagaactaga   1380

agcaagattt gcaggtattg atggcacctc cacatatacc agtggtgatc agaaaactat   1440

aaagtccact aggaaaaaaa acagtgggaa gaccccacat ctcctgctaa tgttattgcc   1500

ctcctacaga cttgagtcac aacagaccaa ccggcggaag aagcgtgctt tggatgcggc   1560

ctattgcttt agaaatgtgc aggataattg ctgcctacgt ccactttaca ttgatttcaa   1620

gagggatcta gggtggaaat ggatacacga acccaaaggg tacaatgcca acttctgtgc   1680

tggagcatgc ccgtatttat ggagttcaga cactcagcac agcagggtcc tgagcttata   1740

taataccata aatccagaag catctgcttc tccttgctgc gtgtcccaag atttagaacc   1800

tctaaccatt ctctactaca ttggcaaaac acccaagatt gaacagcttt ctaatatgat   1860

tgtaaagtct tgcaaatgca gctaaaattc ttggaaaagt ggcaagacca aaatgacaat   1920

gatgatgata atgatgatga cgacgacaac gatgatgctt gtaacaagaa aacataagag   1980

agccttggtt catcagtgtt aaaaaatttt tgaaaaggcg gtactagttc agacactttg   2040

gaagtttgtg ttctgtttgt taaaactggc atctgacaca aaaaaagttg aaggccttat   2100

tctacatttc acctactttg taagtgagag agacaagaag caaatttttt ttaaagaaaa   2160

aaataaacac tggaagaatt tattagtgtt aattatgtga acaacgacaa caacaacaac   2220

aacaacaaac aggaaaatcc cattaagtgg agttgctgta cgtaccgttc ctatcccgcg   2280

cctcacttga tttttctgta ttgctatgca ataggcaccc ttcccattct tactcttaga   2340

gttaacagtg agttatttat tgtgtgttac tatataatga acgtttcatt gcccttggaa   2400

aataaaacag gtgtataaag tggagaccaa atactttgcc agaaactcat ggatggctta   2460

aggaacttga actcaaacga gccagaaaaa aagaggtcat attaatggga tgaaaaccca   2520

agtgagttat tatatgaccg agaaagtctg cattaagata aagaccctga aaacacatgt   2580

tatgtatcag ctgcctaagg aagcttcttg taaggtccaa aaactaaaaa gactgttaat   2640

aaaagaaact ttcagtcaga ataagtctgt aagttttttt ttttcttttt aattgtaaat   2700

ggttctttgt cagtttagta aaccagtgaa atgttgaaat gttttgacat gtactggtca   2760

aacttcagac cttaaaatat tgctgtatag ctatgctata ggttttttcc tttgttttgg   2820

tatatgtaac catacctata ttattaaaat agatggatat agaagccagc ataattgaaa   2880

acacatctgc agatctcttt tgcaaactat taaatcaaaa cattaactac tttatgtgta   2940

atgtgtaaat ttttaccata ttttttatat tctgtaataa tgtcaactat gatttagatt   3000

gacttaaatt tgggctcttt ttaatgatca ctcacaaatg tatgtttctt ttagctggcc   3060

agtacttttg agtaaagccc ctatagtttg acttgcacta caaatgcatt ttttttttaa   3120

taacatttgc cctacttgtg ctttgtgttt ctttcattat tatgacataa gctacctggg   3180

tccacttgtc ttttcttttt tttgtttcac agaaaagatg ggttcgagtt cagtggtctt   3240

catcttccaa gcatcattac taaccaagtc agacgttaac aaatttttat gttaggaaaa   3300

ggaggaatgt tatagataca tagaaaattg aagtaaaatg ttttcatttt agcaaggatt   3360

tagggttcta actaaaactc agaatcttta ttgagttaag aaaagtttct ctaccttggt   3420

ttaatcaata tttttgtaaa atcctattgt tattacaaag aggacacttc ataggaaaca   3480

tctttttctt tagtcaggtt tttaatattc agggggaaat tgaaagatat atattttagt   3540

cgatttttca aaaggggaaa aaagtccagg tcagcataag tcattttgtg tatttcactg   3600

aagttataag gtttttataa atgttctttg aaggggaaaa ggcacaagcc aatttttcct   3660

atgatcaaaa aattctttct ttcctctgag tgagagttat ctatatctga ggctaaagtt   3720

taccttgctt taataaataa tttgccacat cattgcagaa gaggtatcct catgctgggg   3780

ttaatagaat atgtcagttt atcacttgtc gcttatttag ctttaaaata aaaattaata   3840

ggcaaagcaa tggaatattt gcagtttcac ctaaagagca gcataaggag gcgggaatcc   3900

aaagtgaagt tgtttgatat ggtctacttc ttttttggaa tttcctgacc attaattaaa   3960

gaattggatt tgcaagtttg aaaactggaa aagcaagaga tgggatgcca taatagtaaa   4020

cagcccttgt gttggatgta acccaatccc agatttgagt gtgtgttgat tatttttttg   4080

tcttccactt ttctattatg tgtaaatcac ttttatttct gcagacattt tcctctcaga   4140

taggatgaca ttttgttttg tattattttg tctttcctca tgaatgcact gataatattt   4200

taaatgctct attttaagat ctcttgaatc tgtttttttt ttttttaatt tgggggttct   4260

gtaaggtctt tatttcccat aagtaaatat tgccatggga ggggggtgga ggtggcaagg   4320

aaggggtgaa gtgctagtat gcaagtgggc agcaattatt tttgtgttaa tcagcagtac   4380

aatttgatcg ttggcatggt taaaaaatgg aatataagat tagctgtttt gtattttgat   4440

gaccaattac gctgtatttt aacacgatgt atgtctgttt ttgtggtgct ctagtggtaa   4500

ataaattatt tcgatgat                                                 4518


<210>  7156
<211>  414
<212>  PRT
<213>  Homosapiens

<400>  7156

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 
        355                 360                 365             


Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                 375                 380                 


Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile 
385                 390                 395                 400 


Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410                 


<210>  7157
<211>  5142
<212>  DNA
<213>  Homosapiens

<400>  7157
acacacacac acacacacac gcacgcacac acgtgtgcgc ttctctgctc cggagctgct     60

gctgctcctg ctctcagcgc cgcagtggaa ggcaggaccg aaccgctcct tctttaaata    120

tataaatttc agcccaggtc agcctcggcg gcccccctca ccgcgctccc ggcgcccctc    180

ccgtcagttc gccagctgcc agccccggga ccttttcatc tcttcccttt tggccggagg    240

agccgagttc agatccgcca ctccgcaccc gagactgaca cactgaactc cacttcctcc    300

tcttaaattt atttctactt aatagccact cgtctctttt tttccccatc tcattgctcc    360

aagaattttt ttcttcttac tcgccaaagt cagggttccc tctgcccgtc ccgtattaat    420

atttccactt ttggaactac tggccttttc tttttaaagg aattcaagca ggatacgttt    480

ttctgttggg cattgactag attgtttgca aaagtttcgc atcaaaaaca acaacaacaa    540

aaaaccaaac aactctcctt gatctatact ttgagaattg ttgatttctt ttttttattc    600

tgacttttaa aaacaacttt tttttccact tttttaaaaa atgcactact gtgtgctgag    660

cgcttttctg atcctgcatc tggtcacggt cgcgctcagc ctgtctacct gcagcacact    720

cgatatggac cagttcatgc gcaagaggat cgaggcgatc cgcgggcaga tcctgagcaa    780

gctgaagctc accagtcccc cagaagacta tcctgagccc gaggaagtcc ccccggaggt    840

gatttccatc tacaacagca ccagggactt gctccaggag aaggcgagcc ggagggcggc    900

cgcctgcgag cgcgagagga gcgacgaaga gtactacgcc aaggaggttt acaaaataga    960

catgccgccc ttcttcccct ccgaaaatgc catcccgccc actttctaca gaccctactt   1020

cagaattgtt cgatttgacg tctcagcaat ggagaagaat gcttccaatt tggtgaaagc   1080

agagttcaga gtctttcgtt tgcagaaccc aaaagccaga gtgcctgaac aacggattga   1140

gctatatcag attctcaagt ccaaagattt aacatctcca acccagcgct acatcgacag   1200

caaagttgtg aaaacaagag cagaaggcga atggctctcc ttcgatgtaa ctgatgctgt   1260

tcatgaatgg cttcaccata aagacaggaa cctgggattt aaaataagct tacactgtcc   1320

ctgctgcact tttgtaccat ctaataatta catcatccca aataaaagtg aagaactaga   1380

agcaagattt gcaggtattg atggcacctc cacatatacc agtggtgatc agaaaactat   1440

aaagtccact aggaaaaaaa acagtgggaa gaccccacat ctcctgctaa tgttattgcc   1500

ctcctacaga cttgagtcac aacagaccaa ccggcggaag aagcgtgctt tggatgcggc   1560

ctattgcttt agaaatgtgc aggataattg ctgcctacgt ccactttaca ttgatttcaa   1620

gagggatcta gggtggaaat ggatacacga acccaaaggg tacaatgcca acttctgtgc   1680

tggagcatgc ccgtatttat ggagttcaga cactcagcac agcagggtcc tgagcttata   1740

taataccata aatccagaag catctgcttc tccttgctgc gtgtcccaag atttagaacc   1800

tctaaccatt ctctactaca ttggcaaaac acccaagatt gaacagcttt ctaatatgat   1860

tgtaaagtct tgcaaatgca gctaaaattc ttggaaaagt ggcaagacca aaatgacaat   1920

gatgatgata atgatgatga cgacgacaac gatgatgctt gtaacaagaa aacataagag   1980

agccttggtt catcagtgtt aaaaaatttt tgaaaaggcg gtactagttc agacactttg   2040

gaagtttgtg ttctgtttgt taaaactggc atctgacaca aaaaaagttg aaggccttat   2100

tctacatttc acctactttg taagtgagag agacaagaag caaatttttt ttaaagaaaa   2160

aaataaacac tggaagaatt tattagtgtt aattatgtga acaacgacaa caacaacaac   2220

aacaacaaac aggaaaatcc cattaagtgg agttgctgta cgtaccgttc ctatcccgcg   2280

cctcacttga tttttctgta ttgctatgca ataggcaccc ttcccattct tactcttaga   2340

gttaacagtg agttatttat tgtgtgttac tatataatga acgtttcatt gcccttggaa   2400

aataaaacag gtgtataaag tggagaccaa atactttgcc agaaactcat ggatggctta   2460

aggaacttga actcaaacga gccagaaaaa aagaggtcat attaatggga tgaaaaccca   2520

agtgagttat tatatgaccg agaaagtctg cattaagata aagaccctga aaacacatgt   2580

tatgtatcag ctgcctaagg aagcttcttg taaggtccaa aaactaaaaa gactgttaat   2640

aaaagaaact ttcagtcaga ataagtctgt aagttttttt ttttcttttt aattgtaaat   2700

ggttctttgt cagtttagta aaccagtgaa atgttgaaat gttttgacat gtactggtca   2760

aacttcagac cttaaaatat tgctgtatag ctatgctata ggttttttcc tttgttttgg   2820

tatatgtaac catacctata ttattaaaat agatggatat agaagccagc ataattgaaa   2880

acacatctgc agatctcttt tgcaaactat taaatcaaaa cattaactac tttatgtgta   2940

atgtgtaaat ttttaccata ttttttatat tctgtaataa tgtcaactat gatttagatt   3000

gacttaaatt tgggctcttt ttaatgatca ctcacaaatg tatgtttctt ttagctggcc   3060

agtacttttg agtaaagccc ctatagtttg acttgcacta caaatgcatt ttttttttaa   3120

taacatttgc cctacttgtg ctttgtgttt ctttcattat tatgacataa gctacctggg   3180

tccacttgtc ttttcttttt tttgtttcac agaaaagatg ggttcgagtt cagtggtctt   3240

catcttccaa gcatcattac taaccaagtc agacgttaac aaatttttat gttaggaaaa   3300

ggaggaatgt tatagataca tagaaaattg aagtaaaatg ttttcatttt agcaaggatt   3360

tagggttcta actaaaactc agaatcttta ttgagttaag aaaagtttct ctaccttggt   3420

ttaatcaata tttttgtaaa atcctattgt tattacaaag aggacacttc ataggaaaca   3480

tctttttctt tagtcaggtt tttaatattc agggggaaat tgaaagatat atattttagt   3540

cgatttttca aaaggggaaa aaagtccagg tcagcataag tcattttgtg tatttcactg   3600

aagttataag gtttttataa atgttctttg aaggggaaaa ggcacaagcc aatttttcct   3660

atgatcaaaa aattctttct ttcctctgag tgagagttat ctatatctga ggctaaagtt   3720

taccttgctt taataaataa tttgccacat cattgcagaa gaggtatcct catgctgggg   3780

ttaatagaat atgtcagttt atcacttgtc gcttatttag ctttaaaata aaaattaata   3840

ggcaaagcaa tggaatattt gcagtttcac ctaaagagca gcataaggag gcgggaatcc   3900

aaagtgaagt tgtttgatat ggtctacttc ttttttggaa tttcctgacc attaattaaa   3960

gaattggatt tgcaagtttg aaaactggaa aagcaagaga tgggatgcca taatagtaaa   4020

cagcccttgt gttggatgta acccaatccc agatttgagt gtgtgttgat tatttttttg   4080

tcttccactt ttctattatg tgtaaatcac ttttatttct gcagacattt tcctctcaga   4140

taggatgaca ttttgttttg tattattttg tctttcctca tgaatgcact gataatattt   4200

taaatgctct attttaagat ctcttgaatc tgtttttttt ttttttaatt tgggggttct   4260

gtaaggtctt tatttcccat aagtaaatat tgccatggga ggggggtgga ggtggcaagg   4320

aaggggtgaa gtgctagtat gcaagtgggc agcaattatt tttgtgttaa tcagcagtac   4380

aatttgatcg ttggcatggt taaaaaatgg aatataagat tagctgtttt gtattttgat   4440

gaccaattac gctgtatttt aacacgatgt atgtctgttt ttgtggtgct ctagtggtaa   4500

ataaattatt tcgatgatat gtggatgtct ttttcctatc agtaccatca tcgagtctag   4560

aaaacacctg tgatgcaata agactatctc aagctggaaa agtcatacca cctttccgat   4620

tgccctctgt gctttctccc ttaaggacag tcacttcaga agtcatgctt taaagcacaa   4680

gagtcaggcc atatccatca aggatagaag aaatccctgt gccgtctttt tattccctta   4740

tttattgcta tttggtaatt gtttgagatt tagtttccat ccagcttgac tgccgaccag   4800

aaaaaatgca gagagatgtt tgcaccatgc tttggctttc tggttctatg ttctgccaac   4860

gccagggcca aaagaactgg tctagacagt atcccctgta gccccataac ttggatagtt   4920

gctgagccag ccagatataa caagagccac gtgctttctg gggttggttg tttgggatca   4980

gctacttgcc tgtcagtttc actggtacca ctgcaccaca aacaaaaaaa cccaccctat   5040

ttcctccaat ttttttggct gctacctaca agaccagact cctcaaacga gttgccaatc   5100

tcttaataaa taggattaat aaaaaaagta attgtgactc aa                      5142


<210>  7158
<211>  414
<212>  PRT
<213>  Homosapiens

<400>  7158

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 
        355                 360                 365             


Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                 375                 380                 


Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile 
385                 390                 395                 400 


Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410                 


<210>  7159
<211>  395
<212>  DNA
<213>  Homosapiens

<400>  7159
atgccatccc gcccactttc tacagaccct acttcagaat tgttcgattt gacgtctcag     60

caatggagaa gaatgcttcc aatttggtga aagcagagtt cagagtcttt cgtttgcaga    120

acccaaaagc cagagtgcct gaacaacgga ttgagctata tcagattctc aagtccaaag    180

atttaacatc tccaacccag cgctacatcg acagcaaagt tgtgaaaaca agagcagaag    240

gcgaatggct ctccttcgat gtaactgatg ctgttcatga atggcttcac cataaaggtt    300

acaagccact ctctcttttc ctcccaagat gttcagtatc cctaagttac tttaaattga    360

ttgcagattt aagggtatag acacacatac aaatg                               395


<210>  7160
<211>  105
<212>  PRT
<213>  Homosapiens

<400>  7160

Met Glu Lys Asn Ala Ser Asn Leu Val Lys Ala Glu Phe Arg Val Phe 
1               5                   10                  15      


Arg Leu Gln Asn Pro Lys Ala Arg Val Pro Glu Gln Arg Ile Glu Leu 
            20                  25                  30          


Tyr Gln Ile Leu Lys Ser Lys Asp Leu Thr Ser Pro Thr Gln Arg Tyr 
        35                  40                  45              


Ile Asp Ser Lys Val Val Lys Thr Arg Ala Glu Gly Glu Trp Leu Ser 
    50                  55                  60                  


Phe Asp Val Thr Asp Ala Val His Glu Trp Leu His His Lys Gly Tyr 
65                  70                  75                  80  


Lys Pro Leu Ser Leu Phe Leu Pro Arg Cys Ser Val Ser Leu Ser Tyr 
                85                  90                  95      


Phe Lys Leu Ile Ala Asp Leu Arg Val 
            100                 105 


<210>  7161
<211>  3362
<212>  DNA
<213>  Homosapiens

<400>  7161
cgacagcaaa gttgtgaaaa caagagcaga aggcgaatgg ctctccttcg atgtaactga     60

tgctgttcat gaatggcttc accataaagg ttacaagcca ctctctcttt tcctcccaag    120

atgttcaaca ggaacctggg atttaaaata agcttacact gtccctgctg cacttttgta    180

ccatctaata attacatcat cccaaataaa agtgaagaac tagaagcaag atttgcaggt    240

attgatggca cctccacata taccagtggt gatcagaaaa ctataaagtc cactaggaaa    300

aaaaacagtg ggaagacccc acatctcctg ctaatgttat tgccctccta cagacttgag    360

tcacaacaga ccaaccggcg gaagaagcgt gctttggatg cggcctattg ctttagaaat    420

gtgcaggata attgctgcct acgtccactt tacattgatt tcaagaggga tctagggtgg    480

aaatggatac acgaacccaa agggtacaat gccaacttct gtgctggagc atgcccgtat    540

ttatggagtt cagacactca gcacagcagg gtcctgagct tatataatac cataaatcca    600

gaagcatctg cttctccttg ctgcgtgtcc caagatttag aacctctaac cattctctac    660

tacattggca aaacacccaa gattgaacag ctttctaata tgattgtaaa gtcttgcaaa    720

tgcagctaaa attcttggaa aagtggcaag accaaaatga caatgatgat gataatgatg    780

atgacgacga caacgatgat gcttgtaaca agaaaacata agagagcctt ggttcatcag    840

tgttaaaaaa tttttgaaaa ggcggtacta gttcagacac tttggaagtt tgtgttctgt    900

ttgttaaaac tggcatctga cacaaaaaaa gttgaaggcc ttattctaca tttcacctac    960

tttgtaagtg agagagacaa gaagcaaatt ttttttaaag aaaaaaataa acactggaag   1020

aatttattag tgttaattat gtgaacaacg acaacaacaa caacaacaac aaacaggaaa   1080

atcccattaa gtggagttgc tgtacgtacc gttcctatcc cgcgcctcac ttgatttttc   1140

tgtattgcta tgcaataggc acccttccca ttcttactct tagagttaac agtgagttat   1200

ttattgtgtg ttactatata atgaacgttt cattgccctt ggaaaataaa acaggtgtat   1260

aaagtggaga ccaaatactt tgccagaaac tcatggatgg cttaaggaac ttgaactcaa   1320

acgagccaga aaaaaagagg tcatattaat gggatgaaaa cccaagtgag ttattatatg   1380

accgagaaag tctgcattaa gataaagacc ctgaaaacac atgttatgta tcagctgcct   1440

aaggaagctt cttgtaaggt ccaaaaacta aaaagactgt taataaaaga aactttcagt   1500

cagaataagt ctgtaagttt ttttttttct ttttaattgt aaatggttct ttgtcagttt   1560

agtaaaccag tgaaatgttg aaatgttttg acatgtactg gtcaaacttc agaccttaaa   1620

atattgctgt atagctatgc tataggtttt ttcctttgtt ttggtatatg taaccatacc   1680

tatattatta aaatagatgg atatagaagc cagcataatt gaaaacacat ctgcagatct   1740

cttttgcaaa ctattaaatc aaaacattaa ctactttatg tgtaatgtgt aaatttttac   1800

catatttttt atattctgta ataatgtcaa ctatgattta gattgactta aatttgggct   1860

ctttttaatg atcactcaca aatgtatgtt tcttttagct ggccagtact tttgagtaaa   1920

gcccctatag tttgacttgc actacaaatg catttttttt ttaataacat ttgccctact   1980

tgtgctttgt gtttctttca ttattatgac ataagctacc tgggtccact tgtcttttct   2040

tttttttgtt tcacagaaaa gatgggttcg agttcagtgg tcttcatctt ccaagcatca   2100

ttactaacca agtcagacgt taacaaattt ttatgttagg aaaaggagga atgttataga   2160

tacatagaaa attgaagtaa aatgttttca ttttagcaag gatttagggt tctaactaaa   2220

actcagaatc tttattgagt taagaaaagt ttctctacct tggtttaatc aatatttttg   2280

taaaatccta ttgttattac aaagaggaca cttcatagga aacatctttt tctttagtca   2340

ggtttttaat attcaggggg aaattgaaag atatatattt tagtcgattt ttcaaaaggg   2400

gaaaaaagtc caggtcagca taagtcattt tgtgtatttc actgaagtta taaggttttt   2460

ataaatgttc tttgaagggg aaaaggcaca agccaatttt tcctatgatc aaaaaattct   2520

ttctttcctc tgagtgagag ttatctatat ctgaggctaa agtttacctt gctttaataa   2580

ataatttgcc acatcattgc agaagaggta tcctcatgct ggggttaata gaatatgtca   2640

gtttatcact tgtcgcttat ttagctttaa aataaaaatt aataggcaaa gcaatggaat   2700

atttgcagtt tcacctaaag agcagcataa ggaggcggga atccaaagtg aagttgtttg   2760

atatggtcta cttctttttt ggaatttcct gaccattaat taaagaattg gatttgcaag   2820

tttgaaaact ggaaaagcaa gagatgggat gccataatag taaacagccc ttgtgttgga   2880

tgtaacccaa tcccagattt gagtgtgtgt tgattatttt tttgtcttcc acttttctat   2940

tatgtgtaaa tcacttttat ttctgcagac attttcctct cagataggat gacattttgt   3000

tttgtattat tttgtctttc ctcatgaatg cactgataat attttaaatg ctctatttta   3060

agatctcttg aatctgtttt tttttttttt aatttggggg ttctgtaagg tctttatttc   3120

ccataagtaa atattgccat gggagggggg tggaggtggc aaggaagggg tgaagtgcta   3180

gtatgcaagt gggcagcaat tatttttgtg ttaatcagca gtacaatttg atcgttggca   3240

tggttaaaaa atggaatata agattagctg ttttgtattt tgatgaccaa ttacgctgta   3300

ttttaacacg atgtatgtct gtttttgtgg tgctctagtg gtaaataaat tatttcgatg   3360

at                                                                  3362


<210>  7162
<211>  202
<212>  PRT
<213>  Homosapiens

<400>  7162

Met Phe Asn Arg Asn Leu Gly Phe Lys Ile Ser Leu His Cys Pro Cys 
1               5                   10                  15      


Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn Lys Ser Glu 
            20                  25                  30          


Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser Thr Tyr Thr 
        35                  40                  45              


Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys Asn Ser Gly 
    50                  55                  60                  


Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr Arg Leu Glu 
65                  70                  75                  80  


Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp Ala Ala Tyr 
                85                  90                  95      


Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro Leu Tyr Ile 
            100                 105                 110         


Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly 
        115                 120                 125             


Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu Trp Ser Ser 
    130                 135                 140                 


Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr Ile Asn Pro 
145                 150                 155                 160 


Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu Glu Pro Leu 
                165                 170                 175     


Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu Gln Leu Ser 
            180                 185                 190         


Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
        195                 200         


<210>  7163
<211>  3986
<212>  DNA
<213>  Homosapiens

<400>  7163
cgacagcaaa gttgtgaaaa caagagcaga aggcgaatgg ctctccttcg atgtaactga     60

tgctgttcat gaatggcttc accataaagg ttacaagcca ctctctcttt tcctcccaag    120

atgttcaaca ggaacctggg atttaaaata agcttacact gtccctgctg cacttttgta    180

ccatctaata attacatcat cccaaataaa agtgaagaac tagaagcaag atttgcaggt    240

attgatggca cctccacata taccagtggt gatcagaaaa ctataaagtc cactaggaaa    300

aaaaacagtg ggaagacccc acatctcctg ctaatgttat tgccctccta cagacttgag    360

tcacaacaga ccaaccggcg gaagaagcgt gctttggatg cggcctattg ctttagaaat    420

gtgcaggata attgctgcct acgtccactt tacattgatt tcaagaggga tctagggtgg    480

aaatggatac acgaacccaa agggtacaat gccaacttct gtgctggagc atgcccgtat    540

ttatggagtt cagacactca gcacagcagg gtcctgagct tatataatac cataaatcca    600

gaagcatctg cttctccttg ctgcgtgtcc caagatttag aacctctaac cattctctac    660

tacattggca aaacacccaa gattgaacag ctttctaata tgattgtaaa gtcttgcaaa    720

tgcagctaaa attcttggaa aagtggcaag accaaaatga caatgatgat gataatgatg    780

atgacgacga caacgatgat gcttgtaaca agaaaacata agagagcctt ggttcatcag    840

tgttaaaaaa tttttgaaaa ggcggtacta gttcagacac tttggaagtt tgtgttctgt    900

ttgttaaaac tggcatctga cacaaaaaaa gttgaaggcc ttattctaca tttcacctac    960

tttgtaagtg agagagacaa gaagcaaatt ttttttaaag aaaaaaataa acactggaag   1020

aatttattag tgttaattat gtgaacaacg acaacaacaa caacaacaac aaacaggaaa   1080

atcccattaa gtggagttgc tgtacgtacc gttcctatcc cgcgcctcac ttgatttttc   1140

tgtattgcta tgcaataggc acccttccca ttcttactct tagagttaac agtgagttat   1200

ttattgtgtg ttactatata atgaacgttt cattgccctt ggaaaataaa acaggtgtat   1260

aaagtggaga ccaaatactt tgccagaaac tcatggatgg cttaaggaac ttgaactcaa   1320

acgagccaga aaaaaagagg tcatattaat gggatgaaaa cccaagtgag ttattatatg   1380

accgagaaag tctgcattaa gataaagacc ctgaaaacac atgttatgta tcagctgcct   1440

aaggaagctt cttgtaaggt ccaaaaacta aaaagactgt taataaaaga aactttcagt   1500

cagaataagt ctgtaagttt ttttttttct ttttaattgt aaatggttct ttgtcagttt   1560

agtaaaccag tgaaatgttg aaatgttttg acatgtactg gtcaaacttc agaccttaaa   1620

atattgctgt atagctatgc tataggtttt ttcctttgtt ttggtatatg taaccatacc   1680

tatattatta aaatagatgg atatagaagc cagcataatt gaaaacacat ctgcagatct   1740

cttttgcaaa ctattaaatc aaaacattaa ctactttatg tgtaatgtgt aaatttttac   1800

catatttttt atattctgta ataatgtcaa ctatgattta gattgactta aatttgggct   1860

ctttttaatg atcactcaca aatgtatgtt tcttttagct ggccagtact tttgagtaaa   1920

gcccctatag tttgacttgc actacaaatg catttttttt ttaataacat ttgccctact   1980

tgtgctttgt gtttctttca ttattatgac ataagctacc tgggtccact tgtcttttct   2040

tttttttgtt tcacagaaaa gatgggttcg agttcagtgg tcttcatctt ccaagcatca   2100

ttactaacca agtcagacgt taacaaattt ttatgttagg aaaaggagga atgttataga   2160

tacatagaaa attgaagtaa aatgttttca ttttagcaag gatttagggt tctaactaaa   2220

actcagaatc tttattgagt taagaaaagt ttctctacct tggtttaatc aatatttttg   2280

taaaatccta ttgttattac aaagaggaca cttcatagga aacatctttt tctttagtca   2340

ggtttttaat attcaggggg aaattgaaag atatatattt tagtcgattt ttcaaaaggg   2400

gaaaaaagtc caggtcagca taagtcattt tgtgtatttc actgaagtta taaggttttt   2460

ataaatgttc tttgaagggg aaaaggcaca agccaatttt tcctatgatc aaaaaattct   2520

ttctttcctc tgagtgagag ttatctatat ctgaggctaa agtttacctt gctttaataa   2580

ataatttgcc acatcattgc agaagaggta tcctcatgct ggggttaata gaatatgtca   2640

gtttatcact tgtcgcttat ttagctttaa aataaaaatt aataggcaaa gcaatggaat   2700

atttgcagtt tcacctaaag agcagcataa ggaggcggga atccaaagtg aagttgtttg   2760

atatggtcta cttctttttt ggaatttcct gaccattaat taaagaattg gatttgcaag   2820

tttgaaaact ggaaaagcaa gagatgggat gccataatag taaacagccc ttgtgttgga   2880

tgtaacccaa tcccagattt gagtgtgtgt tgattatttt tttgtcttcc acttttctat   2940

tatgtgtaaa tcacttttat ttctgcagac attttcctct cagataggat gacattttgt   3000

tttgtattat tttgtctttc ctcatgaatg cactgataat attttaaatg ctctatttta   3060

agatctcttg aatctgtttt tttttttttt aatttggggg ttctgtaagg tctttatttc   3120

ccataagtaa atattgccat gggagggggg tggaggtggc aaggaagggg tgaagtgcta   3180

gtatgcaagt gggcagcaat tatttttgtg ttaatcagca gtacaatttg atcgttggca   3240

tggttaaaaa atggaatata agattagctg ttttgtattt tgatgaccaa ttacgctgta   3300

ttttaacacg atgtatgtct gtttttgtgg tgctctagtg gtaaataaat tatttcgatg   3360

atatgtggat gtctttttcc tatcagtacc atcatcgagt ctagaaaaca cctgtgatgc   3420

aataagacta tctcaagctg gaaaagtcat accacctttc cgattgccct ctgtgctttc   3480

tcccttaagg acagtcactt cagaagtcat gctttaaagc acaagagtca ggccatatcc   3540

atcaaggata gaagaaatcc ctgtgccgtc tttttattcc cttatttatt gctatttggt   3600

aattgtttga gatttagttt ccatccagct tgactgccga ccagaaaaaa tgcagagaga   3660

tgtttgcacc atgctttggc tttctggttc tatgttctgc caacgccagg gccaaaagaa   3720

ctggtctaga cagtatcccc tgtagcccca taacttggat agttgctgag ccagccagat   3780

ataacaagag ccacgtgctt tctggggttg gttgtttggg atcagctact tgcctgtcag   3840

tttcactggt accactgcac cacaaacaaa aaaacccacc ctatttcctc caattttttt   3900

ggctgctacc tacaagacca gactcctcaa acgagttgcc aatctcttaa taaataggat   3960

taataaaaaa agtaattgtg actcaa                                        3986


<210>  7164
<211>  202
<212>  PRT
<213>  Homosapiens

<400>  7164

Met Phe Asn Arg Asn Leu Gly Phe Lys Ile Ser Leu His Cys Pro Cys 
1               5                   10                  15      


Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn Lys Ser Glu 
            20                  25                  30          


Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser Thr Tyr Thr 
        35                  40                  45              


Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys Asn Ser Gly 
    50                  55                  60                  


Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr Arg Leu Glu 
65                  70                  75                  80  


Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp Ala Ala Tyr 
                85                  90                  95      


Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro Leu Tyr Ile 
            100                 105                 110         


Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly 
        115                 120                 125             


Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu Trp Ser Ser 
    130                 135                 140                 


Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr Ile Asn Pro 
145                 150                 155                 160 


Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu Glu Pro Leu 
                165                 170                 175     


Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu Gln Leu Ser 
            180                 185                 190         


Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
        195                 200         


<210>  7165
<211>  1285
<212>  DNA
<213>  Homosapiens

<400>  7165
ggggtcatat cagaaagata tgtttgatga aattaactac agaatcaaga agtatatact     60

caaaaatgca aatactacaa tatataagac aatgctggag tgcaatggtg caatcttggc    120

tcactgcaac ctccgcctcc tgggttcaaa tgattctcct gcctcagcct cccaagtagc    180

tgggactaca gaccgcaacc aattgctctt ccttcccatt gaaagaaacc caggctgtac    240

ctgctctttc atctcctgtg tggaaaacat ctatcggctg gaagccctga gtcttcattt    300

tcaaggattt tagttgtaag ctgtttaagg cataagctaa agtttcaggc agaggtaatt    360

ttagtagtta agcctgattt ttacttccac cctctgtcct ccagggctat atgggaagct    420

ttctgtgagt ggataagctc tttagctaag atgtaaacat gttccctgct atctgataaa    480

ggttcctgga gactgacact ttaaaaaaaa aaaaaaaaag aaagtgagga aaaaaagaaa    540

aggagaaact gaatccaagg cttacaaagg gattagaaaa ctgtacccca gatggaaaat    600

tttatgggct ctggagaaaa tgtgtaagtg aaatatcggt atcataaaat aacaggaaat    660

agtgtaatct acctgatgga gaaaattgtc actttaaaaa aactatccta atttccttca    720

aaattgttct tgtttttgag ccaataaact tcagctaagc tcaccatggg tctttcttct    780

gccaaactcc tacttaccaa cagaaccttt gtgtgtttac aattgaaact tttccattct    840

atttttttct aattaaaata aagccaccca gaggcggaca gaaatcatac aataaggaaa    900

gaaaattgct aatgatctgg gtaaattatg atccagaagt ttagaggaaa attagagtgc    960

atattatagc aaagaactca aaacaaattt ggggtcaacc caaagaaatg tataaggggg   1020

aaatcctaag ttttccttta ataagtaata atgataatac aattagtttt aactatgtgc   1080

atggtagaag ataaatcagc agatgaatgc ctgaggcact tactatgggg aaatgtgata   1140

gtcatgtaat ttttgctttg ttttttttct tccccttcaa ctgctaggat agattatatg   1200

acttagtaaa ccattgctga gtatacgagg aaaaacttgt ttggttgctt agaccacata   1260

ttatcaggat taatttcctc ttatc                                         1285


<210>  7166
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  7166

Met Phe Asp Glu Ile Asn Tyr Arg Ile Lys Lys Tyr Ile Leu Lys Asn 
1               5                   10                  15      


Ala Asn Thr Thr Ile Tyr Lys Thr Met Leu Glu Cys Asn Gly Ala Ile 
            20                  25                  30          


Leu Ala His Cys Asn Leu Arg Leu Leu Gly Ser Asn Asp Ser Pro Ala 
        35                  40                  45              


Ser Ala Ser Gln Val Ala Gly Thr Thr Asp Arg Asn Gln Leu Leu Phe 
    50                  55                  60                  


Leu Pro Ile Glu Arg Asn Pro Gly Cys Thr Cys Ser Phe Ile Ser Cys 
65                  70                  75                  80  


Val Glu Asn Ile Tyr Arg Leu Glu Ala Leu Ser Leu His Phe Gln Gly 
                85                  90                  95      


Phe 
    


<210>  7167
<211>  1335
<212>  DNA
<213>  Homosapiens

<400>  7167
gctatcctcc ccttcatttg aacagaggaa gttcttcacc ttttagaacc caatattcac     60

tcccagcttt cctacttgaa aattcgtttg ttatccttcc catattttct ctaaacaaac    120

tttctcagaa tgttgttaaa attctgaaag ggatgacaaa aactgttggt acaggaaggc    180

ggcagagcaa ggatatgtcc agtgggagaa aagttaaacc attgcatgcc aataaacaaa    240

gaccgcaacc aattgctctt ccttcccatt gaaagaaacc caggctgtac ctgctctttc    300

atctcctgtg tggaaaacat ctatcggctg gaagccctga gtcttcattt tcaaggattt    360

tagttgtaag ctgtttaagg cataagctaa agtttcaggc agaggtaatt ttagtagtta    420

agcctgattt ttacttccac cctctgtcct ccagggctat atgggaagct ttctgtgagt    480

ggataagctc tttagctaag atgtaaacat gttccctgct atctgataaa ggttcctgga    540

gactgacact ttaaaaaaaa aaaaaaaaag aaagtgagga aaaaaagaaa aggagaaact    600

gaatccaagg cttacaaagg gattagaaaa ctgtacccca gatggaaaat tttatgggct    660

ctggagaaaa tgtgtaagtg aaatatcggt atcataaaat aacaggaaat agtgtaatct    720

acctgatgga gaaaattgtc actttaaaaa aactatccta atttccttca aaattgttct    780

tgtttttgag ccaataaact tcagctaagc tcaccatggg tctttcttct gccaaactcc    840

tacttaccaa cagaaccttt gtgtgtttac aattgaaact tttccattct atttttttct    900

aattaaaata aagccaccca gaggcggaca gaaatcatac aataaggaaa gaaaattgct    960

aatgatctgg gtaaattatg atccagaagt ttagaggaaa attagagtgc atattatagc   1020

aaagaactca aaacaaattt ggggtcaacc caaagaaatg tataaggggg aaatcctaag   1080

ttttccttta ataagtaata atgataatac aattagtttt aactatgtgc atggtagaag   1140

ataaatcagc agatgaatgc ctgaggcact tactatgggg aaatgtgata gtcatgtaat   1200

ttttgctttg ttttttttct tccccttcaa ctgctaggat agattatatg acttagtaaa   1260

ccattgctga gtatacgagg aaaaacttgt ttggttgctt agaccacata ttatcaggat   1320

taatttcctc ttatc                                                    1335


<210>  7168
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  7168

Met Pro Ile Asn Lys Asp Arg Asn Gln Leu Leu Phe Leu Pro Ile Glu 
1               5                   10                  15      


Arg Asn Pro Gly Cys Thr Cys Ser Phe Ile Ser Cys Val Glu Asn Ile 
            20                  25                  30          


Tyr Arg Leu Glu Ala Leu Ser Leu His Phe Gln Gly Phe 
        35                  40                  45  


<210>  7169
<211>  1324
<212>  DNA
<213>  Homosapiens

<400>  7169
ggagggctgg ctgagcggcg ggacacaagg ccccaaagcg agggtggtgg accagtgacc     60

gcccgataga aagaggaaga ctaacggggg aggctggggg caggtggcgc tgcccgtgca    120

tctacagccg gggctggcga cgggggagcc acccactggg ccctatttgg gcccggcgac    180

acctccactt gggcaatact ggggtaaccg aggggaggat gtttcccgag ctgtagaaaa    240

ccaggacgta aaattgaaat ccacctgagc catgcaggaa gatcagagag gcgctatgcc    300

tccctgccgg cgacacgata cagcgctgca gaaccgaccc cgacgcagcc gccatcgctg    360

atgccactgc cagtcatgcg gttccgcccc tgcgttgccg cgcggggccg cgcacgcaaa    420

tacgcaggca cgcgcgggag cacgcccggg agcgcgcatg cgcagcgctg ctggcccgct    480

ctctgaggag ctttcaatac tttggggtca agtttgaggc agttgtaact gtactgagtt    540

tagttttgct aataatggta ttctacgtgt gtcagcctcg tgtggacttc tgtaatgact    600

aatggatatg tttatatcct gagcatttgc tgtaggaatt ttaaatgcaa tcccaaaact    660

caagattacc ttatttggag aaatattcgt gttactatgt ttaaaattta atagaaccat    720

attttacctt tcactttggg actcgcacag gatgtttgca gctcttgata tacaggaact    780

agaacgtgtc ttttaagagc atgcggtttt ataattacgt ggaagtatgc tacgcaaggg    840

aaaaaagcct cttgctagtg ttaagggtct tcataaacag aaaccgcaag gaacctggga    900

tctgacagct gttggaggaa tgcctgtgag gaaggaggag gaacagaaga atgctttgat    960

gtcttaaatg gtacatccaa acttaagtga aatagagctg tgaggacatt ttggggagaa   1020

gtgacctaga taagcactga ctgttgcatt catctctctt cttgctgatt gtgatgattt   1080

cctgtgccat agccattcaa agtctgccaa aaaagctagc atgtaatttt ctttctctac   1140

ttctctacat ttggaggatg gaaatgtaga tgttcttcca ttgtgccagc ctcctcattc   1200

ttctttctcc aatgccgcat cttcctgcaa acttcctgcc acaactcaaa caacaggaaa   1260

ataaatgatc tgaaatcctc ctgaactgca gcctacctat cgtggtctct atgggtgcaa   1320

actt                                                                1324


<210>  7170
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  7170

Met Leu Arg Lys Gly Lys Lys Pro Leu Ala Ser Val Lys Gly Leu His 
1               5                   10                  15      


Lys Gln Lys Pro Gln Gly Thr Trp Asp Leu Thr Ala Val Gly Gly Met 
            20                  25                  30          


Pro Val Arg Lys Glu Glu Glu Gln Lys Asn Ala Leu Met Ser 
        35                  40                  45      


<210>  7171
<211>  1403
<212>  DNA
<213>  Homosapiens

<400>  7171
ggagggctgg ctgagcggcg ggacacaagg ccccaaagcg agggtggtgg accagtgacc     60

gcccgataga aagaggaaga ctaacggggg aggctggggg caggtggcgc tgcccgtgca    120

tctacagccg gggctggcga cgggggagcc acccactggg ccctatttgg gcccggcgac    180

acctccactt gggcaatact ggggtaaccg aggggaggat gtttcccgag ctgtagaaaa    240

ccaggacgta aaattgaaat ccacctgagc catgcaggaa gatcagagag gcgctatgcc    300

tccctgccgg cgacacgata cagcgctgca gaaccgaccc cgacgcagcc gccatcgctg    360

atgccactgc cagtcatgcg gttccgcccc tgcgttgccg cgcggggccg cgcacgcaaa    420

tacgcaggca cgcgcgggag cacgcccggg agcgcgcatg cgcagcgctg ctggcccgct    480

ctctgaggag ctttcaatac tttggggtca agtttgaggc agttgtaact gtactgagtt    540

tagttttgct aataatggta ttctacgtgt gtcagcctcg tgtggacttc tgtaatgact    600

aatggatatg tttatatcct gagcatttgc tgtaggaatt ttaaatgcaa tcccaaaact    660

caagattacc ttatttggag aaatattcgt gttactatgt ttaaaattta atagaaccat    720

attttacctt tcactttggg actcgcacag gatgtttgca gctcttgata tacaggaact    780

agaacgtgtc ttttaagagc atgcggtttt ataattacgt ggaagtatgc tacgcaaggg    840

aaaaaagcct cttgctagtg ttaagggtct tcataaacag aaaccgcaag gaacctggga    900

tctgacagct gttggaggaa tgcctgtgag gaaggaggag gaacagaaga atgctttgat    960

gtcttaaatg gtacatccaa acttaagtga aatagagctg tgaggacatt ttggggagaa   1020

gtgacctaga taagcactga ctgttgcatt catctctctt cttgctgatt gtgatgattt   1080

cctgtgccat agccattcaa agtctgccaa aaaaggcctt gcctcctgga tggcattttt   1140

gaacccaccc tgggccagag gggagcccac ttctttgaag acagaaacac aggactggca   1200

acatttacca taagctgact gagcagccat tgggccttga gtgaacattg gtggtagcca   1260

ggcagtactt gtctcagtac ttgcctcagg cctggggtgt cggtgaccac agggagagca   1320

tccatctgct tgaggaaagg agaacaaaga aaataaaggg cttaatcttg cacttgattg   1380

ccagctcagc catagtagaa tac                                           1403


<210>  7172
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  7172

Met Leu Arg Lys Gly Lys Lys Pro Leu Ala Ser Val Lys Gly Leu His 
1               5                   10                  15      


Lys Gln Lys Pro Gln Gly Thr Trp Asp Leu Thr Ala Val Gly Gly Met 
            20                  25                  30          


Pro Val Arg Lys Glu Glu Glu Gln Lys Asn Ala Leu Met Ser 
        35                  40                  45      


<210>  7173
<211>  1897
<212>  DNA
<213>  Homosapiens

<400>  7173
cgcggcaacg caggggcgga accgcatgac tggcagtggc atcagcgatg gcggctgcgt     60

cggggtcggt tctgcagcgc tgtatcgtgt cgccggcagg gaggcatagc gcctctctga    120

tcttcctgca tggctcaggt gattctggac aaggattaag aatgtggatc aagcaggttt    180

taaatcaaga tttaacattc caacacataa aaattattta tccaacagct cctcccagat    240

catatactcc tatgaaagga ggaatctcca atgtatggtt tgacagattt aaaataacca    300

atgactgccc agaacacctt gaatcaattg atgtcatgtg tcaagtgctt actgatttga    360

ttgatgaaga agtaaaaagt ggcatcaaga agaacaggat attaatagga ggattctcta    420

tgggaggatg catggcaata catttagcat atagaaatca tcaagatgtg gcaggagtat    480

ttgctctttc tagttttctg aataaagcat ctgctgttta ccaggctctt cagaagagta    540

atggtgtact tcctgaatta tttcagtgtc atggtactgc agatgagtta gttcttcatt    600

cttgggcaga agagacaaac tcaatgttaa aatctctagg agtgaccacg aagtttcata    660

gttttccaaa tgtttaccat gagctaagca aaactgagtt agacatattg aagttatgga    720

ttcttacaaa gctgccagga gaaatggaaa aacaaaaatg aatgaatcaa gagtgatttg    780

ttaatgtaag tgtaatgtct ttgtgaaaag tgatttttac tgccaaatta taatgataat    840

taaaatatta agaaataaca ctttcctgac ttttttatta ttaaaatgct tatcactgta    900

gacagtagct aatcttatta atgaaaaaca atagacaaac atctgtgcat aatttttcag    960

acacaattct gtaaatattt ggaaaccttt taagtattta aacttttaaa tttttgaaat   1020

aaagtattct aaactaatat aaataaggac aatgaaaaaa catgaaagga cttagcataa   1080

tgttatttta tcttttctac aactttgttt aaattacctt tccaaagata tttgtgttta   1140

tgtaattttc cacggaataa cattaatact ctaggtttat aaaccggttt cacattattt   1200

catttgatca tcacaagagc tttgtgaagt aagccgagaa gttgttactg gtatttaata   1260

atagcaatag aggagttaaa gactttccca cagcttgcag gtcaagacaa gaaattcagg   1320

tctcctaatt ctcagtggag ctctatttct gttaacccaa attgctgctc tgttttaggt   1380

ctcaatttca tctgtaaaat gatactaata gtacttatcc cattggattt ttgttgagat   1440

ttaaataaat agccaaaagc caatacataa taaacactca ataaagatta accataagga   1500

gagtcatgat ctggttccag gaatacattg ttagatgact gaaaaattgt attacttcaa   1560

tgaaaatact ataaataata acattttcat atattagttg gttctcatgc atacataatc   1620

taattttatt tgatcctcac aactgtttaa gttttattaa atatacatta tccctatttg   1680

tataaataga atcatacaat acctgcctgc tttcattcaa caaaattatc atgagatttt   1740

tccatgttgt gtacatcaat agttcatcta ttttattgct cagtaatatt ccattgtgtg   1800

gatgtatcac tatttgttta cacattcacc actgatatat aagttgcttc cagtgtgagg   1860

ctgttttaaa taaagctgct atgaatattc atgtaag                            1897


<210>  7174
<211>  237
<212>  PRT
<213>  Homosapiens

<400>  7174

Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro 
1               5                   10                  15      


Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp 
            20                  25                  30          


Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp 
        35                  40                  45              


Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg 
    50                  55                  60                  


Ser Tyr Thr Pro Met Lys Gly Gly Ile Ser Asn Val Trp Phe Asp Arg 
65                  70                  75                  80  


Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val 
                85                  90                  95      


Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly 
            100                 105                 110         


Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys 
        115                 120                 125             


Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val 
    130                 135                 140                 


Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala 
145                 150                 155                 160 


Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly 
                165                 170                 175     


Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser 
            180                 185                 190         


Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn 
        195                 200                 205             


Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp 
    210                 215                 220                 


Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
225                 230                 235         


<210>  7175
<211>  848
<212>  DNA
<213>  Homosapiens

<400>  7175
aggggcggaa ccgcatgact ggcagtggca tcagcgatgg cggctgcgtc ggggtcggtt     60

ctgcagcgct gtatcgtgtc gccggcaggg aggcatagcg cctctctgat cttcctgcat    120

ggctcaggtg attctggaca aggattaaga atgtggatca agcaggtttt aaatcaagat    180

ttaacattcc aacacataaa aattatttat ccaacagctc ctcccagatc atatactcct    240

atgaaaggag gaatctccaa tgtatggttt gacagattta aaataaccaa tgactgccca    300

gaacaccttg aatcaattga tgtcatgtgt caagtgctta ctgatttgat tgatgaagaa    360

gtaaaaagtg gcatcaagaa gaacaggata ttaataggag gattctctat gggaggatgc    420

atggcaatac atttagcata tagaaatcat caagatgtgg caggagtatt tgctctttct    480

agttttctga ataaagcatc tgctgtttac caggctcttc agaagagtaa tggtgtactt    540

cctgaattat ttcagtgtca tggtactgca gatgagttag ttcttcattc ttgggcagaa    600

gagacaaact caatgttaaa atctctagga gtgaccacga agtttcatag ttttccaaat    660

gtttaccatg agctaagcaa aactgagtta gacatattga agttatggat tcttacaaag    720

ctgccaggag aaatggaaaa acaaaaatga atgaatcaag agtgatttgt taatgtaagt    780

gtaatgtctt tgtgaaaagt gatttttact gccaaattat aatgataatt aaaatattaa    840

gaaataac                                                             848


<210>  7176
<211>  237
<212>  PRT
<213>  Homosapiens

<400>  7176

Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro 
1               5                   10                  15      


Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp 
            20                  25                  30          


Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp 
        35                  40                  45              


Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg 
    50                  55                  60                  


Ser Tyr Thr Pro Met Lys Gly Gly Ile Ser Asn Val Trp Phe Asp Arg 
65                  70                  75                  80  


Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val 
                85                  90                  95      


Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly 
            100                 105                 110         


Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys 
        115                 120                 125             


Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val 
    130                 135                 140                 


Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala 
145                 150                 155                 160 


Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly 
                165                 170                 175     


Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser 
            180                 185                 190         


Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn 
        195                 200                 205             


Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp 
    210                 215                 220                 


Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
225                 230                 235         


<210>  7177
<211>  1702
<212>  DNA
<213>  Homosapiens

<400>  7177
atgactggca gtggcatcag cgatggcggc tgcgtcgggg tcggttctgc agcgctgtat     60

cgtgtcgccg gcagggaggc atagcgcctc tctgatcttc ctgcatggct caggtgattc    120

tggacaagga ttaagaatgt ggatcaagca ggttttaaat caagatttaa cattccaaca    180

cataaaaatt atttatccaa cagctcctcc caggaggatt ctctatggga ggatgcatgg    240

caatacattt agcatataga aatcatcaag atgtggcagg agtatttgct ctttctagtt    300

ttctgaataa agcatctgct gtttaccagg ctcttcagaa gagtaatggt gtacttcctg    360

aattatttca gtgtcatggt actgcagatg agttagttct tcattcttgg gcagaagaga    420

caaactcaat gttaaaatct ctaggagtga ccacgaagtt tcatagtttt ccaaatgttt    480

accatgagct aagcaaaact gagttagaca tattgaagtt atggattctt acaaagctgc    540

caggagaaat ggaaaaacaa aaatgaatga atcaagagtg atttgttaat gtaagtgtaa    600

tgtctttgtg aaaagtgatt tttactgcca aattataatg ataattaaaa tattaagaaa    660

taacactttc ctgacttttt tattattaaa atgcttatca ctgtagacag tagctaatct    720

tattaatgaa aaacaataga caaacatctg tgcataattt ttcagacaca attctgtaaa    780

tatttggaaa ccttttaagt atttaaactt ttaaattttt gaaataaagt attctaaact    840

aatataaata aggacaatga aaaaacatga aaggacttag cataatgtta ttttatcttt    900

tctacaactt tgtttaaatt acctttccaa agatatttgt gtttatgtaa ttttccacgg    960

aataacatta atactctagg tttataaacc ggtttcacat tatttcattt gatcatcaca   1020

agagctttgt gaagtaagcc gagaagttgt tactggtatt taataatagc aatagaggag   1080

ttaaagactt tcccacagct tgcaggtcaa gacaagaaat tcaggtctcc taattctcag   1140

tggagctcta tttctgttaa cccaaattgc tgctctgttt taggtctcaa tttcatctgt   1200

aaaatgatac taatagtact tatcccattg gatttttgtt gagatttaaa taaatagcca   1260

aaagccaata cataataaac actcaataaa gattaaccat aaggagagtc atgatctggt   1320

tccaggaata cattgttaga tgactgaaaa attgtattac ttcaatgaaa atactataaa   1380

taataacatt ttcatatatt agttggttct catgcataca taatctaatt ttatttgatc   1440

ctcacaactg tttaagtttt attaaatata cattatccct atttgtataa atagaatcat   1500

acaatacctg cctgctttca ttcaacaaaa ttatcatgag atttttccat gttgtgtaca   1560

tcaatagttc atctatttta ttgctcagta atattccatt gtgtggatgt atcactattt   1620

gtttacacat tcaccactga tatataagtt gcttccagtg tgaggctgtt ttaaataaag   1680

ctgctatgaa tattcatgta ag                                            1702


<210>  7178
<211>  113
<212>  PRT
<213>  Homosapiens

<400>  7178

Met Gly Gly Cys Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp 
1               5                   10                  15      


Val Ala Gly Val Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala 
            20                  25                  30          


Val Tyr Gln Ala Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe 
        35                  40                  45              


Gln Cys His Gly Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu 
    50                  55                  60                  


Glu Thr Asn Ser Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His 
65                  70                  75                  80  


Ser Phe Pro Asn Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile 
                85                  90                  95      


Leu Lys Leu Trp Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln 
            100                 105                 110         


Lys 
    


<210>  7179
<211>  780
<212>  DNA
<213>  Homosapiens

<400>  7179
ggcagtggca tcagcgatgg cggctgcgtc ggggtcggtt ctgcagcgct gtatcgtgtc     60

gccggcaggg aggcatagcg cctctctgat cttcctgcat ggctcaggtg attctggaca    120

aggattaaga atgtggatca agcaggtttt aaatcaagat ttaacattcc aacacataaa    180

aattatttat ccaacagctc ctcccagatt taaaataacc aatgactgcc cagaacacct    240

tgaatcaatt gatgtcatgt gtcaagtgct tactgatttg attgatgaag aagtaaaaag    300

tggcatcaag aagaacagga tattaatagg aggattctct atgggaggat gcatggcaat    360

acatttagca tatagaaatc atcaagatgt ggcaggagta tttgctcttt ctagttttct    420

gaataaagca tctgctgttt accaggctct tcagaagagt aatggtgtac ttcctgaatt    480

atttcagtgt catggtactg cagatgagtt agttcttcat tcttgggcag aagagacaaa    540

ctcaatgtta aaatctctag gagtgaccac gaagtttcat agttttccaa atgtttacca    600

tgagctaagc aaaactgagt tagacatatt gaagttatgg attcttacaa agctgccagg    660

agaaatggaa aaacaaaaat gaatgaatca agagtgattt gttaatgtaa gtgtaatgtc    720

tttgtgaaaa gtgattttta ctgccaaatt ataatgataa ttaaaatatt aagaaataac    780


<210>  7180
<211>  221
<212>  PRT
<213>  Homosapiens

<400>  7180

Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro 
1               5                   10                  15      


Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp 
            20                  25                  30          


Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp 
        35                  40                  45              


Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg 
    50                  55                  60                  


Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val 
65                  70                  75                  80  


Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly 
                85                  90                  95      


Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys 
            100                 105                 110         


Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val 
        115                 120                 125             


Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala 
    130                 135                 140                 


Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly 
145                 150                 155                 160 


Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser 
                165                 170                 175     


Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn 
            180                 185                 190         


Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp 
        195                 200                 205             


Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
    210                 215                 220     


<210>  7181
<211>  1818
<212>  DNA
<213>  Homosapiens

<400>  7181
ggcagtggca tcagcgatgg cggctgcgtc ggggtcggtt ctgcagcgct gtatcgtgtc     60

gccggcaggg aggcatagcg cctctctgat cttcctgcat ggctcaggtg attctggaca    120

aggattaaga atgtggatca agcaggtttt aaatcaagat ttaacattcc aacacataaa    180

aattatttat ccaacagctc ctcccagatt taaaataacc aatgactgcc cagaacacct    240

tgaatcaatt gatgtcatgt gtcaagtgct tactgatttg attgatgaag aagtaaaaag    300

tggcatcaag aagaacagga tattaatagg aggattctct atgggaggat gcatggcaat    360

acatttagca tatagaaatc atcaagatgt ggcaggagta tttgctcttt ctagttttct    420

gaataaagca tctgctgttt accaggctct tcagaagagt aatggtgtac ttcctgaatt    480

atttcagtgt catggtactg cagatgagtt agttcttcat tcttgggcag aagagacaaa    540

ctcaatgtta aaatctctag gagtgaccac gaagtttcat agttttccaa atgtttacca    600

tgagctaagc aaaactgagt tagacatatt gaagttatgg attcttacaa agctgccagg    660

agaaatggaa aaacaaaaat gaatgaatca agagtgattt gttaatgtaa gtgtaatgtc    720

tttgtgaaaa gtgattttta ctgccaaatt ataatgataa ttaaaatatt aagaaataac    780

actttcctga cttttttatt attaaaatgc ttatcactgt agacagtagc taatcttatt    840

aatgaaaaac aatagacaaa catctgtgca taatttttca gacacaattc tgtaaatatt    900

tggaaacctt ttaagtattt aaacttttaa atttttgaaa taaagtattc taaactaata    960

taaataagga caatgaaaaa acatgaaagg acttagcata atgttatttt atcttttcta   1020

caactttgtt taaattacct ttccaaagat atttgtgttt atgtaatttt ccacggaata   1080

acattaatac tctaggttta taaaccggtt tcacattatt tcatttgatc atcacaagag   1140

ctttgtgaag taagccgaga agttgttact ggtatttaat aatagcaata gaggagttaa   1200

agactttccc acagcttgca ggtcaagaca agaaattcag gtctcctaat tctcagtgga   1260

gctctatttc tgttaaccca aattgctgct ctgttttagg tctcaatttc atctgtaaaa   1320

tgatactaat agtacttatc ccattggatt tttgttgaga tttaaataaa tagccaaaag   1380

ccaatacata ataaacactc aataaagatt aaccataagg agagtcatga tctggttcca   1440

ggaatacatt gttagatgac tgaaaaattg tattacttca atgaaaatac tataaataat   1500

aacattttca tatattagtt ggttctcatg catacataat ctaattttat ttgatcctca   1560

caactgttta agttttatta aatatacatt atccctattt gtataaatag aatcatacaa   1620

tacctgcctg ctttcattca acaaaattat catgagattt ttccatgttg tgtacatcaa   1680

tagttcatct attttattgc tcagtaatat tccattgtgt ggatgtatca ctatttgttt   1740

acacattcac cactgatata taagttgctt ccagtgtgag gctgttttaa ataaagctgc   1800

tatgaatatt catgtaag                                                 1818


<210>  7182
<211>  221
<212>  PRT
<213>  Homosapiens

<400>  7182

Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro 
1               5                   10                  15      


Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp 
            20                  25                  30          


Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp 
        35                  40                  45              


Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg 
    50                  55                  60                  


Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val 
65                  70                  75                  80  


Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly 
                85                  90                  95      


Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys 
            100                 105                 110         


Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val 
        115                 120                 125             


Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala 
    130                 135                 140                 


Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly 
145                 150                 155                 160 


Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser 
                165                 170                 175     


Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn 
            180                 185                 190         


Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp 
        195                 200                 205             


Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
    210                 215                 220     


<210>  7183
<211>  637
<212>  DNA
<213>  Homosapiens

<400>  7183
gcagtggcat cagcgatggc ggctgcgtcg gggtcggttc tgcagcgctg tatcgtgtcg     60

ccggcaggga ggcatagcgc ctctctgatc ttcctgcatg gctcaggtga ttctggacaa    120

ggattaagaa tgtggatcaa gcaggtttta aatcaagatt taacattcca acacataaaa    180

attatttatc caacagctcc tcccagttac actgttggac caagttttgc cagatcatat    240

actcctatga aaggaggaat ctccaatgta tggtttgaca gatttaaaat aaccaatgac    300

tgcccagaac accttgaatc aattgatgtc atgtgtcaag tgcttactga tttgattgat    360

gaagaagtaa aaagtggcat caagaagaac aggatattaa taggtaagac ctttaaatgt    420

tggtaattta tcactgttca cttttgtcta attctataca tcaaatctta cttggaacat    480

tatttagaag cacttgtata tcattcgatg cattcatagt ttcagataaa ctttacatat    540

tgaggatttc aaagatatta gaattataaa cagcagcgca tgaaacttta attgattttc    600

tttttgaata ataacggatt ttgagactct tgtggca                             637


<210>  7184
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  7184

Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro 
1               5                   10                  15      


Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp 
            20                  25                  30          


Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp 
        35                  40                  45              


Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Ser 
    50                  55                  60                  


Tyr Thr Val Gly Pro Ser Phe Ala Arg Ser Tyr Thr Pro Met Lys Gly 
65                  70                  75                  80  


Gly Ile Ser Asn Val Trp Phe Asp Arg Phe Lys Ile Thr Asn Asp Cys 
                85                  90                  95      


Pro Glu His Leu Glu Ser Ile Asp Val Met Cys Gln Val Leu Thr Asp 
            100                 105                 110         


Leu Ile Asp Glu Glu Val Lys Ser Gly Ile Lys Lys Asn Arg Ile Leu 
        115                 120                 125             


Ile Gly Lys Thr Phe Lys Cys Trp 
    130                 135     


<210>  7185
<211>  650
<212>  DNA
<213>  Homosapiens

<400>  7185
catcagcgat ggcggctgcg tcggggtcgg ttctgcagcg ctgtatcgtg tcgccggcag     60

ggaggcatag cgcctctctg atcttcctgc atggctcagg tgattctgga caaggattaa    120

gaatgtggat caagcaggtt ttaaatcaag atttaacatt ccaacacata aaaattattt    180

atccaacagc tcctcccagg aggattctct atgggaggat gcatggcaat acatttagca    240

tatagaaatc atcaagatgt ggcaggagta tttgctcttt ctagttttct gaataaagca    300

tctgctgttt accaggctct tcagaagagt aatggtgtac ttcctgaatt atttcagtgt    360

catggtactg cagatgagtt agttcttcat tcttgggcag aagagacaaa ctcaatgtta    420

aaatctctag gagtgaccac gaagtttcat agttttccaa atgtttacca tgagctaagc    480

aaaactgagt tagacatatt gaagttatgg attcttacaa agctgccagg agaaatggaa    540

aaacaaaaat gaatgaatca agagtgattt gttaatgtaa gtgtaatgtc tttgtgaaaa    600

gtgattttta ctgccaaatt ataatgataa ttaaaatatt aagaaataac               650


<210>  7186
<211>  113
<212>  PRT
<213>  Homosapiens

<400>  7186

Met Gly Gly Cys Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp 
1               5                   10                  15      


Val Ala Gly Val Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala 
            20                  25                  30          


Val Tyr Gln Ala Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe 
        35                  40                  45              


Gln Cys His Gly Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu 
    50                  55                  60                  


Glu Thr Asn Ser Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His 
65                  70                  75                  80  


Ser Phe Pro Asn Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile 
                85                  90                  95      


Leu Lys Leu Trp Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln 
            100                 105                 110         


Lys 
    


<210>  7187
<211>  1714
<212>  DNA
<213>  Homosapiens

<400>  7187
atcagcgatg gcggctgcgt cggggtcggt tctgcagcgc tgtatcgtgt cgccggcagg     60

gaggcatagc gcctctctga tcttcctgca tggctcaggt gattctggac aaggattaag    120

aatgtggatc aagcaggttt taaatcaaga tttaacattc caacacataa aaattattta    180

tccaacagct cctcccagtt acactgttgg accaagtttt gccaggagga ttctctatgg    240

gaggatgcat ggcaatacat ttagcatata gaaatcatca agatgtggca ggagtatttg    300

ctctttctag ttttctgaat aaagcatctg ctgtttacca ggctcttcag aagagtaatg    360

gtgtacttcc tgaattattt cagtgtcatg gtactgcaga tgagttagtt cttcattctt    420

gggcagaaga gacaaactca atgttaaaat ctctaggagt gaccacgaag tttcatagtt    480

ttccaaatgt ttaccatgag ctaagcaaaa ctgagttaga catattgaag ttatggattc    540

ttacaaagct gccaggagaa atggaaaaac aaaaatgaat gaatcaagag tgatttgtta    600

atgtaagtgt aatgtctttg tgaaaagtga tttttactgc caaattataa tgataattaa    660

aatattaaga aataacactt tcctgacttt tttattatta aaatgcttat cactgtagac    720

agtagctaat cttattaatg aaaaacaata gacaaacatc tgtgcataat ttttcagaca    780

caattctgta aatatttgga aaccttttaa gtatttaaac ttttaaattt ttgaaataaa    840

gtattctaaa ctaatataaa taaggacaat gaaaaaacat gaaaggactt agcataatgt    900

tattttatct tttctacaac tttgtttaaa ttacctttcc aaagatattt gtgtttatgt    960

aattttccac ggaataacat taatactcta ggtttataaa ccggtttcac attatttcat   1020

ttgatcatca caagagcttt gtgaagtaag ccgagaagtt gttactggta tttaataata   1080

gcaatagagg agttaaagac tttcccacag cttgcaggtc aagacaagaa attcaggtct   1140

cctaattctc agtggagctc tatttctgtt aacccaaatt gctgctctgt tttaggtctc   1200

aatttcatct gtaaaatgat actaatagta cttatcccat tggatttttg ttgagattta   1260

aataaatagc caaaagccaa tacataataa acactcaata aagattaacc ataaggagag   1320

tcatgatctg gttccaggaa tacattgtta gatgactgaa aaattgtatt acttcaatga   1380

aaatactata aataataaca ttttcatata ttagttggtt ctcatgcata cataatctaa   1440

ttttatttga tcctcacaac tgtttaagtt ttattaaata tacattatcc ctatttgtat   1500

aaatagaatc atacaatacc tgcctgcttt cattcaacaa aattatcatg agatttttcc   1560

atgttgtgta catcaatagt tcatctattt tattgctcag taatattcca ttgtgtggat   1620

gtatcactat ttgtttacac attcaccact gatatataag ttgcttccag tgtgaggctg   1680

ttttaaataa agctgctatg aatattcatg taag                               1714


<210>  7188
<211>  113
<212>  PRT
<213>  Homosapiens

<400>  7188

Met Gly Gly Cys Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp 
1               5                   10                  15      


Val Ala Gly Val Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala 
            20                  25                  30          


Val Tyr Gln Ala Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe 
        35                  40                  45              


Gln Cys His Gly Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu 
    50                  55                  60                  


Glu Thr Asn Ser Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His 
65                  70                  75                  80  


Ser Phe Pro Asn Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile 
                85                  90                  95      


Leu Lys Leu Trp Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln 
            100                 105                 110         


Lys 
    


<210>  7189
<211>  1140
<212>  DNA
<213>  Homosapiens

<400>  7189
cagcgatggc ggctgcgtcg gggtcggttc tgcagcgctg tatcgtgtcg ccggcaggga     60

ggcatagcgc ctctctgatc ttcctgcatg gctcaggtgg atttcaattt tacgtcctgg    120

ttttctacag ctcgggaaac atcctcccct cggttacccc agtattgccc aagtggaggt    180

gtcgccgggc ccaaataggg cccagtgggt ggctcccccg tcgccagccc cggctgtaga    240

tgcacgggca gcgccacctg cccccagcct cccccgttag tcttcctctt tctatcgggc    300

ggtcactggt ccaccaccct cgctttgggg ccttgtgtcc cgccgctcag ccagccctcc    360

atccccacaa cacacctccc cattcctcgc cccaagttta aacagagcaa gttagtaagg    420

tgattctgga caaggattaa gaatgtggat caagcaggtt ttaaatcaag atttaacatt    480

ccaacacata aaaattattt atccaacagc tcctcccaga tcatatactc ctatgaaagg    540

aggaatctcc aatgtatggt ttgacagatt taaaataacc aatgactgcc cagaacacct    600

tgaatcaatt gatgtcatgt gtcaagtgct tactgatttg attgatgaag aagtaaaaag    660

tggcatcaag aagaacagga tattaatagg aggattctct atgggaggat gcatggcaat    720

acatttagca tatagaaatc atcaagatgt ggcaggagta tttgctcttt ctagttttct    780

gaataaagca tctgctgttt accaggctct tcagaagagt aatggtgtac ttcctgaatt    840

atttcagtgt catggtactg cagatgagtt agttcttcat tcttgggcag aagagacaaa    900

ctcaatgtta aaatctctag gagtgaccac gaagtttcat agttttccaa atgtttacca    960

tgagctaagc aaaactgagt tagacatatt gaagttatgg attcttacaa agctgccagg   1020

agaaatggaa aaacaaaaat gaatgaatca agagtgattt gttaatgtaa gtgtaatgtc   1080

tttgtgaaaa gtgattttta ctgccaaatt ataatgataa ttaaaatatt aagaaataac   1140


<210>  7190
<211>  199
<212>  PRT
<213>  Homosapiens

<400>  7190

Met Trp Ile Lys Gln Val Leu Asn Gln Asp Leu Thr Phe Gln His Ile 
1               5                   10                  15      


Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg Ser Tyr Thr Pro Met Lys 
            20                  25                  30          


Gly Gly Ile Ser Asn Val Trp Phe Asp Arg Phe Lys Ile Thr Asn Asp 
        35                  40                  45              


Cys Pro Glu His Leu Glu Ser Ile Asp Val Met Cys Gln Val Leu Thr 
    50                  55                  60                  


Asp Leu Ile Asp Glu Glu Val Lys Ser Gly Ile Lys Lys Asn Arg Ile 
65                  70                  75                  80  


Leu Ile Gly Gly Phe Ser Met Gly Gly Cys Met Ala Ile His Leu Ala 
                85                  90                  95      


Tyr Arg Asn His Gln Asp Val Ala Gly Val Phe Ala Leu Ser Ser Phe 
            100                 105                 110         


Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala Leu Gln Lys Ser Asn Gly 
        115                 120                 125             


Val Leu Pro Glu Leu Phe Gln Cys His Gly Thr Ala Asp Glu Leu Val 
    130                 135                 140                 


Leu His Ser Trp Ala Glu Glu Thr Asn Ser Met Leu Lys Ser Leu Gly 
145                 150                 155                 160 


Val Thr Thr Lys Phe His Ser Phe Pro Asn Val Tyr His Glu Leu Ser 
                165                 170                 175     


Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp Ile Leu Thr Lys Leu Pro 
            180                 185                 190         


Gly Glu Met Glu Lys Gln Lys 
        195                 


<210>  7191
<211>  2178
<212>  DNA
<213>  Homosapiens

<400>  7191
cagcgatggc ggctgcgtcg gggtcggttc tgcagcgctg tatcgtgtcg ccggcaggga     60

ggcatagcgc ctctctgatc ttcctgcatg gctcaggtgg atttcaattt tacgtcctgg    120

ttttctacag ctcgggaaac atcctcccct cggttacccc agtattgccc aagtggaggt    180

gtcgccgggc ccaaataggg cccagtgggt ggctcccccg tcgccagccc cggctgtaga    240

tgcacgggca gcgccacctg cccccagcct cccccgttag tcttcctctt tctatcgggc    300

ggtcactggt ccaccaccct cgctttgggg ccttgtgtcc cgccgctcag ccagccctcc    360

atccccacaa cacacctccc cattcctcgc cccaagttta aacagagcaa gttagtaagg    420

tgattctgga caaggattaa gaatgtggat caagcaggtt ttaaatcaag atttaacatt    480

ccaacacata aaaattattt atccaacagc tcctcccaga tcatatactc ctatgaaagg    540

aggaatctcc aatgtatggt ttgacagatt taaaataacc aatgactgcc cagaacacct    600

tgaatcaatt gatgtcatgt gtcaagtgct tactgatttg attgatgaag aagtaaaaag    660

tggcatcaag aagaacagga tattaatagg aggattctct atgggaggat gcatggcaat    720

acatttagca tatagaaatc atcaagatgt ggcaggagta tttgctcttt ctagttttct    780

gaataaagca tctgctgttt accaggctct tcagaagagt aatggtgtac ttcctgaatt    840

atttcagtgt catggtactg cagatgagtt agttcttcat tcttgggcag aagagacaaa    900

ctcaatgtta aaatctctag gagtgaccac gaagtttcat agttttccaa atgtttacca    960

tgagctaagc aaaactgagt tagacatatt gaagttatgg attcttacaa agctgccagg   1020

agaaatggaa aaacaaaaat gaatgaatca agagtgattt gttaatgtaa gtgtaatgtc   1080

tttgtgaaaa gtgattttta ctgccaaatt ataatgataa ttaaaatatt aagaaataac   1140

actttcctga cttttttatt attaaaatgc ttatcactgt agacagtagc taatcttatt   1200

aatgaaaaac aatagacaaa catctgtgca taatttttca gacacaattc tgtaaatatt   1260

tggaaacctt ttaagtattt aaacttttaa atttttgaaa taaagtattc taaactaata   1320

taaataagga caatgaaaaa acatgaaagg acttagcata atgttatttt atcttttcta   1380

caactttgtt taaattacct ttccaaagat atttgtgttt atgtaatttt ccacggaata   1440

acattaatac tctaggttta taaaccggtt tcacattatt tcatttgatc atcacaagag   1500

ctttgtgaag taagccgaga agttgttact ggtatttaat aatagcaata gaggagttaa   1560

agactttccc acagcttgca ggtcaagaca agaaattcag gtctcctaat tctcagtgga   1620

gctctatttc tgttaaccca aattgctgct ctgttttagg tctcaatttc atctgtaaaa   1680

tgatactaat agtacttatc ccattggatt tttgttgaga tttaaataaa tagccaaaag   1740

ccaatacata ataaacactc aataaagatt aaccataagg agagtcatga tctggttcca   1800

ggaatacatt gttagatgac tgaaaaattg tattacttca atgaaaatac tataaataat   1860

aacattttca tatattagtt ggttctcatg catacataat ctaattttat ttgatcctca   1920

caactgttta agttttatta aatatacatt atccctattt gtataaatag aatcatacaa   1980

tacctgcctg ctttcattca acaaaattat catgagattt ttccatgttg tgtacatcaa   2040

tagttcatct attttattgc tcagtaatat tccattgtgt ggatgtatca ctatttgttt   2100

acacattcac cactgatata taagttgctt ccagtgtgag gctgttttaa ataaagctgc   2160

tatgaatatt catgtaag                                                 2178


<210>  7192
<211>  199
<212>  PRT
<213>  Homosapiens

<400>  7192

Met Trp Ile Lys Gln Val Leu Asn Gln Asp Leu Thr Phe Gln His Ile 
1               5                   10                  15      


Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg Ser Tyr Thr Pro Met Lys 
            20                  25                  30          


Gly Gly Ile Ser Asn Val Trp Phe Asp Arg Phe Lys Ile Thr Asn Asp 
        35                  40                  45              


Cys Pro Glu His Leu Glu Ser Ile Asp Val Met Cys Gln Val Leu Thr 
    50                  55                  60                  


Asp Leu Ile Asp Glu Glu Val Lys Ser Gly Ile Lys Lys Asn Arg Ile 
65                  70                  75                  80  


Leu Ile Gly Gly Phe Ser Met Gly Gly Cys Met Ala Ile His Leu Ala 
                85                  90                  95      


Tyr Arg Asn His Gln Asp Val Ala Gly Val Phe Ala Leu Ser Ser Phe 
            100                 105                 110         


Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala Leu Gln Lys Ser Asn Gly 
        115                 120                 125             


Val Leu Pro Glu Leu Phe Gln Cys His Gly Thr Ala Asp Glu Leu Val 
    130                 135                 140                 


Leu His Ser Trp Ala Glu Glu Thr Asn Ser Met Leu Lys Ser Leu Gly 
145                 150                 155                 160 


Val Thr Thr Lys Phe His Ser Phe Pro Asn Val Tyr His Glu Leu Ser 
                165                 170                 175     


Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp Ile Leu Thr Lys Leu Pro 
            180                 185                 190         


Gly Glu Met Glu Lys Gln Lys 
        195                 


<210>  7193
<211>  835
<212>  DNA
<213>  Homosapiens

<400>  7193
cggctgcgtc ggggtcggtt ctgcagcgct gtatcgtgtc gccggcaggg aggcatagcg     60

cctctctgat cttcctgcat ggctcaggtg attctggaca aggattaaga atgtggatca    120

agcaggtttt aaatcaagat ttaacattcc aacacataaa aattatttat ccaacagctc    180

ctcccagtta cactgttgga ccaagttttg ccagatcata tactcctatg aaaggaggaa    240

tctccaatgt atggtttgac agatttaaaa taaccaatga ctgcccagaa caccttgaat    300

caattgatgt catgtgtcaa gtgcttactg atttgattga tgaagaagta aaaagtggca    360

tcaagaagaa caggatatta ataggaggat tctctatggg aggatgcatg gcaatacatt    420

tagcatatag aaatcatcaa gatgtggcag gagtatttgc tctttctagt tttctgaata    480

aagcatctgc tgtttaccag gctcttcaga agagtaatgg tgtacttcct gaattatttc    540

agtgtcatgg tactgcagat gagttagttc ttcattcttg ggcagaagag acaaactcaa    600

tgttaaaatc tctaggagtg accacgaagt ttcatagttt tccaaatgtt taccatgagc    660

taagcaaaac tgagttagac atattgaagt tatggattct tacaaagctg ccaggagaaa    720

tggaaaaaca aaaatgaatg aatcaagagt gatttgttaa tgtaagtgta atgtctttgt    780

gaaaagtgat ttttactgcc aaattataat gataattaaa atattaagaa ataac         835


<210>  7194
<211>  208
<212>  PRT
<213>  Homosapiens

<400>  7194

Met Trp Ile Lys Gln Val Leu Asn Gln Asp Leu Thr Phe Gln His Ile 
1               5                   10                  15      


Lys Ile Ile Tyr Pro Thr Ala Pro Pro Ser Tyr Thr Val Gly Pro Ser 
            20                  25                  30          


Phe Ala Arg Ser Tyr Thr Pro Met Lys Gly Gly Ile Ser Asn Val Trp 
        35                  40                  45              


Phe Asp Arg Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser 
    50                  55                  60                  


Ile Asp Val Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val 
65                  70                  75                  80  


Lys Ser Gly Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met 
                85                  90                  95      


Gly Gly Cys Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp Val 
            100                 105                 110         


Ala Gly Val Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val 
        115                 120                 125             


Tyr Gln Ala Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln 
    130                 135                 140                 


Cys His Gly Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu 
145                 150                 155                 160 


Thr Asn Ser Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser 
                165                 170                 175     


Phe Pro Asn Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu 
            180                 185                 190         


Lys Leu Trp Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
        195                 200                 205             


<210>  7195
<211>  1873
<212>  DNA
<213>  Homosapiens

<400>  7195
cggctgcgtc ggggtcggtt ctgcagcgct gtatcgtgtc gccggcaggg aggcatagcg     60

cctctctgat cttcctgcat ggctcaggtg attctggaca aggattaaga atgtggatca    120

agcaggtttt aaatcaagat ttaacattcc aacacataaa aattatttat ccaacagctc    180

ctcccagtta cactgttgga ccaagttttg ccagatcata tactcctatg aaaggaggaa    240

tctccaatgt atggtttgac agatttaaaa taaccaatga ctgcccagaa caccttgaat    300

caattgatgt catgtgtcaa gtgcttactg atttgattga tgaagaagta aaaagtggca    360

tcaagaagaa caggatatta ataggaggat tctctatggg aggatgcatg gcaatacatt    420

tagcatatag aaatcatcaa gatgtggcag gagtatttgc tctttctagt tttctgaata    480

aagcatctgc tgtttaccag gctcttcaga agagtaatgg tgtacttcct gaattatttc    540

agtgtcatgg tactgcagat gagttagttc ttcattcttg ggcagaagag acaaactcaa    600

tgttaaaatc tctaggagtg accacgaagt ttcatagttt tccaaatgtt taccatgagc    660

taagcaaaac tgagttagac atattgaagt tatggattct tacaaagctg ccaggagaaa    720

tggaaaaaca aaaatgaatg aatcaagagt gatttgttaa tgtaagtgta atgtctttgt    780

gaaaagtgat ttttactgcc aaattataat gataattaaa atattaagaa ataacacttt    840

cctgactttt ttattattaa aatgcttatc actgtagaca gtagctaatc ttattaatga    900

aaaacaatag acaaacatct gtgcataatt tttcagacac aattctgtaa atatttggaa    960

accttttaag tatttaaact tttaaatttt tgaaataaag tattctaaac taatataaat   1020

aaggacaatg aaaaaacatg aaaggactta gcataatgtt attttatctt ttctacaact   1080

ttgtttaaat tacctttcca aagatatttg tgtttatgta attttccacg gaataacatt   1140

aatactctag gtttataaac cggtttcaca ttatttcatt tgatcatcac aagagctttg   1200

tgaagtaagc cgagaagttg ttactggtat ttaataatag caatagagga gttaaagact   1260

ttcccacagc ttgcaggtca agacaagaaa ttcaggtctc ctaattctca gtggagctct   1320

atttctgtta acccaaattg ctgctctgtt ttaggtctca atttcatctg taaaatgata   1380

ctaatagtac ttatcccatt ggatttttgt tgagatttaa ataaatagcc aaaagccaat   1440

acataataaa cactcaataa agattaacca taaggagagt catgatctgg ttccaggaat   1500

acattgttag atgactgaaa aattgtatta cttcaatgaa aatactataa ataataacat   1560

tttcatatat tagttggttc tcatgcatac ataatctaat tttatttgat cctcacaact   1620

gtttaagttt tattaaatat acattatccc tatttgtata aatagaatca tacaatacct   1680

gcctgctttc attcaacaaa attatcatga gatttttcca tgttgtgtac atcaatagtt   1740

catctatttt attgctcagt aatattccat tgtgtggatg tatcactatt tgtttacaca   1800

ttcaccactg atatataagt tgcttccagt gtgaggctgt tttaaataaa gctgctatga   1860

atattcatgt aag                                                      1873


<210>  7196
<211>  208
<212>  PRT
<213>  Homosapiens

<400>  7196

Met Trp Ile Lys Gln Val Leu Asn Gln Asp Leu Thr Phe Gln His Ile 
1               5                   10                  15      


Lys Ile Ile Tyr Pro Thr Ala Pro Pro Ser Tyr Thr Val Gly Pro Ser 
            20                  25                  30          


Phe Ala Arg Ser Tyr Thr Pro Met Lys Gly Gly Ile Ser Asn Val Trp 
        35                  40                  45              


Phe Asp Arg Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser 
    50                  55                  60                  


Ile Asp Val Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val 
65                  70                  75                  80  


Lys Ser Gly Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met 
                85                  90                  95      


Gly Gly Cys Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp Val 
            100                 105                 110         


Ala Gly Val Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val 
        115                 120                 125             


Tyr Gln Ala Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln 
    130                 135                 140                 


Cys His Gly Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu 
145                 150                 155                 160 


Thr Asn Ser Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser 
                165                 170                 175     


Phe Pro Asn Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu 
            180                 185                 190         


Lys Leu Trp Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
        195                 200                 205             


<210>  7197
<211>  905
<212>  DNA
<213>  Homosapiens

<400>  7197
agcgcctctc tgatcttcct gcatggctca ggtggatttc aattttacgt cctggttttc     60

tacagctcgg gaaacatcct cccctcggtt accccagtat tgcccaagtg gaggtgtcgc    120

cgggcccaaa tagggcccag tgggtggctc ccccgtcgcc agccccggct gtagatgcac    180

gggcagcgcc acctgccccc agcctccccc gttagtcttc ctctttctat cgggcggtca    240

ctggtccacc accctcgctt tggggccttg tgtcccgccg ctcagccagc cctccatccc    300

cacaacacac ctccccattc ctcgccccaa gtttaaacag agcaagttag taaggtgatt    360

ctggacaagg attaagaatg tggatcaagc aggttttaaa tcaagattta acattccaac    420

acataaaaat tatttatcca acagctcctc ccaggaggat tctctatggg aggatgcatg    480

gcaatacatt tagcatatag aaatcatcaa gatgtggcag gagtatttgc tctttctagt    540

tttctgaata aagcatctgc tgtttaccag gctcttcaga agagtaatgg tgtacttcct    600

gaattatttc agtgtcatgg tactgcagat gagttagttc ttcattcttg ggcagaagag    660

acaaactcaa tgttaaaatc tctaggagtg accacgaagt ttcatagttt tccaaatgtt    720

taccatgagc taagcaaaac tgagttagac atattgaagt tatggattct tacaaagctg    780

ccaggagaaa tggaaaaaca aaaatgaatg aatcaagagt gatttgttaa tgtaagtgta    840

atgtctttgt gaaaagtgat ttttactgcc aaattataat gataattaaa atattaagaa    900

ataac                                                                905


<210>  7198
<211>  113
<212>  PRT
<213>  Homosapiens

<400>  7198

Met Gly Gly Cys Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp 
1               5                   10                  15      


Val Ala Gly Val Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala 
            20                  25                  30          


Val Tyr Gln Ala Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe 
        35                  40                  45              


Gln Cys His Gly Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu 
    50                  55                  60                  


Glu Thr Asn Ser Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His 
65                  70                  75                  80  


Ser Phe Pro Asn Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile 
                85                  90                  95      


Leu Lys Leu Trp Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln 
            100                 105                 110         


Lys 
    


<210>  7199
<211>  773
<212>  DNA
<213>  Homosapiens

<400>  7199
gatgaaaagc ttgtcagact tttcgaagaa agtggtcttt gagccgagac gggtgattct     60

ggacaaggat taagaatgtg gatcaagcag gttttaaatc aagatttaac attccaacac    120

ataaaaatta tttatccaac agctcctccc agatcatata ctcctatgaa aggaggaatc    180

tccaatgtat ggtttgacag atttaaaata accaatgact gcccagaaca ccttgaatca    240

attgatgtca tgtgtcaagt gcttactgat ttgattgatg aagaagtaaa aagtggcatc    300

aagaagaaca ggatattaat aggaggattc tctatgggag gatgcatggc aatacattta    360

gcatatagaa atcatcaaga tgtggcagga gtatttgctc tttctagttt tctgaataaa    420

gcatctgctg tttaccaggc tcttcagaag agtaatggtg tacttcctga attatttcag    480

tgtcatggta ctgcagatga gttagttctt cattcttggg cagaagagac aaactcaatg    540

ttaaaatctc taggagtgac cacgaagttt catagttttc caaatgttta ccatgagcta    600

agcaaaactg agttagacat attgaagtta tggattctta caaagctgcc aggagaaatg    660

gaaaaacaaa aatgaatgaa tcaagagtga tttgttaatg taagtgtaat gtctttgtga    720

aaagtgattt ttactgccaa attataatga taattaaaat attaagaaat aac           773


<210>  7200
<211>  199
<212>  PRT
<213>  Homosapiens

<400>  7200

Met Trp Ile Lys Gln Val Leu Asn Gln Asp Leu Thr Phe Gln His Ile 
1               5                   10                  15      


Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg Ser Tyr Thr Pro Met Lys 
            20                  25                  30          


Gly Gly Ile Ser Asn Val Trp Phe Asp Arg Phe Lys Ile Thr Asn Asp 
        35                  40                  45              


Cys Pro Glu His Leu Glu Ser Ile Asp Val Met Cys Gln Val Leu Thr 
    50                  55                  60                  


Asp Leu Ile Asp Glu Glu Val Lys Ser Gly Ile Lys Lys Asn Arg Ile 
65                  70                  75                  80  


Leu Ile Gly Gly Phe Ser Met Gly Gly Cys Met Ala Ile His Leu Ala 
                85                  90                  95      


Tyr Arg Asn His Gln Asp Val Ala Gly Val Phe Ala Leu Ser Ser Phe 
            100                 105                 110         


Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala Leu Gln Lys Ser Asn Gly 
        115                 120                 125             


Val Leu Pro Glu Leu Phe Gln Cys His Gly Thr Ala Asp Glu Leu Val 
    130                 135                 140                 


Leu His Ser Trp Ala Glu Glu Thr Asn Ser Met Leu Lys Ser Leu Gly 
145                 150                 155                 160 


Val Thr Thr Lys Phe His Ser Phe Pro Asn Val Tyr His Glu Leu Ser 
                165                 170                 175     


Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp Ile Leu Thr Lys Leu Pro 
            180                 185                 190         


Gly Glu Met Glu Lys Gln Lys 
        195                 


<210>  7201
<211>  1811
<212>  DNA
<213>  Homosapiens

<400>  7201
gatgaaaagc ttgtcagact tttcgaagaa agtggtcttt gagccgagac gggtgattct     60

ggacaaggat taagaatgtg gatcaagcag gttttaaatc aagatttaac attccaacac    120

ataaaaatta tttatccaac agctcctccc agatcatata ctcctatgaa aggaggaatc    180

tccaatgtat ggtttgacag atttaaaata accaatgact gcccagaaca ccttgaatca    240

attgatgtca tgtgtcaagt gcttactgat ttgattgatg aagaagtaaa aagtggcatc    300

aagaagaaca ggatattaat aggaggattc tctatgggag gatgcatggc aatacattta    360

gcatatagaa atcatcaaga tgtggcagga gtatttgctc tttctagttt tctgaataaa    420

gcatctgctg tttaccaggc tcttcagaag agtaatggtg tacttcctga attatttcag    480

tgtcatggta ctgcagatga gttagttctt cattcttggg cagaagagac aaactcaatg    540

ttaaaatctc taggagtgac cacgaagttt catagttttc caaatgttta ccatgagcta    600

agcaaaactg agttagacat attgaagtta tggattctta caaagctgcc aggagaaatg    660

gaaaaacaaa aatgaatgaa tcaagagtga tttgttaatg taagtgtaat gtctttgtga    720

aaagtgattt ttactgccaa attataatga taattaaaat attaagaaat aacactttcc    780

tgactttttt attattaaaa tgcttatcac tgtagacagt agctaatctt attaatgaaa    840

aacaatagac aaacatctgt gcataatttt tcagacacaa ttctgtaaat atttggaaac    900

cttttaagta tttaaacttt taaatttttg aaataaagta ttctaaacta atataaataa    960

ggacaatgaa aaaacatgaa aggacttagc ataatgttat tttatctttt ctacaacttt   1020

gtttaaatta cctttccaaa gatatttgtg tttatgtaat tttccacgga ataacattaa   1080

tactctaggt ttataaaccg gtttcacatt atttcatttg atcatcacaa gagctttgtg   1140

aagtaagccg agaagttgtt actggtattt aataatagca atagaggagt taaagacttt   1200

cccacagctt gcaggtcaag acaagaaatt caggtctcct aattctcagt ggagctctat   1260

ttctgttaac ccaaattgct gctctgtttt aggtctcaat ttcatctgta aaatgatact   1320

aatagtactt atcccattgg atttttgttg agatttaaat aaatagccaa aagccaatac   1380

ataataaaca ctcaataaag attaaccata aggagagtca tgatctggtt ccaggaatac   1440

attgttagat gactgaaaaa ttgtattact tcaatgaaaa tactataaat aataacattt   1500

tcatatatta gttggttctc atgcatacat aatctaattt tatttgatcc tcacaactgt   1560

ttaagtttta ttaaatatac attatcccta tttgtataaa tagaatcata caatacctgc   1620

ctgctttcat tcaacaaaat tatcatgaga tttttccatg ttgtgtacat caatagttca   1680

tctattttat tgctcagtaa tattccattg tgtggatgta tcactatttg tttacacatt   1740

caccactgat atataagttg cttccagtgt gaggctgttt taaataaagc tgctatgaat   1800

attcatgtaa g                                                        1811


<210>  7202
<211>  199
<212>  PRT
<213>  Homosapiens

<400>  7202

Met Trp Ile Lys Gln Val Leu Asn Gln Asp Leu Thr Phe Gln His Ile 
1               5                   10                  15      


Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg Ser Tyr Thr Pro Met Lys 
            20                  25                  30          


Gly Gly Ile Ser Asn Val Trp Phe Asp Arg Phe Lys Ile Thr Asn Asp 
        35                  40                  45              


Cys Pro Glu His Leu Glu Ser Ile Asp Val Met Cys Gln Val Leu Thr 
    50                  55                  60                  


Asp Leu Ile Asp Glu Glu Val Lys Ser Gly Ile Lys Lys Asn Arg Ile 
65                  70                  75                  80  


Leu Ile Gly Gly Phe Ser Met Gly Gly Cys Met Ala Ile His Leu Ala 
                85                  90                  95      


Tyr Arg Asn His Gln Asp Val Ala Gly Val Phe Ala Leu Ser Ser Phe 
            100                 105                 110         


Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala Leu Gln Lys Ser Asn Gly 
        115                 120                 125             


Val Leu Pro Glu Leu Phe Gln Cys His Gly Thr Ala Asp Glu Leu Val 
    130                 135                 140                 


Leu His Ser Trp Ala Glu Glu Thr Asn Ser Met Leu Lys Ser Leu Gly 
145                 150                 155                 160 


Val Thr Thr Lys Phe His Ser Phe Pro Asn Val Tyr His Glu Leu Ser 
                165                 170                 175     


Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp Ile Leu Thr Lys Leu Pro 
            180                 185                 190         


Gly Glu Met Glu Lys Gln Lys 
        195                 


<210>  7203
<211>  726
<212>  DNA
<213>  Homosapiens

<400>  7203
aaaatgaggc cagacaggtt cagcagcttg gccaaggtct cttagctgtt actgtgattc     60

tggacaagga ttaagaatgt ggatcaagca ggttttaaat caagatttaa cattccaaca    120

cataaaaatt atttatccaa cagctcctcc cagatttaaa ataaccaatg actgcccaga    180

acaccttgaa tcaattgatg tcatgtgtca agtgcttact gatttgattg atgaagaagt    240

aaaaagtggc atcaagaaga acaggatatt aataggagga ttctctatgg gaggatgcat    300

ggcaatacat ttagcatata gaaatcatca agatgtggca ggagtatttg ctctttctag    360

ttttctgaat aaagcatctg ctgtttacca ggctcttcag aagagtaatg gtgtacttcc    420

tgaattattt cagtgtcatg gtactgcaga tgagttagtt cttcattctt gggcagaaga    480

gacaaactca atgttaaaat ctctaggagt gaccacgaag tttcatagtt ttccaaatgt    540

ttaccatgag ctaagcaaaa ctgagttaga catattgaag ttatggattc ttacaaagct    600

gccaggagaa atggaaaaac aaaaatgaat gaatcaagag tgatttgtta atgtaagtgt    660

aatgtctttg tgaaaagtga tttttactgc caaattataa tgataattaa aatattaaga    720

aataac                                                               726


<210>  7204
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  7204

Met Trp Ile Lys Gln Val Leu Asn Gln Asp Leu Thr Phe Gln His Ile 
1               5                   10                  15      


Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg Phe Lys Ile Thr Asn Asp 
            20                  25                  30          


Cys Pro Glu His Leu Glu Ser Ile Asp Val Met Cys Gln Val Leu Thr 
        35                  40                  45              


Asp Leu Ile Asp Glu Glu Val Lys Ser Gly Ile Lys Lys Asn Arg Ile 
    50                  55                  60                  


Leu Ile Gly Gly Phe Ser Met Gly Gly Cys Met Ala Ile His Leu Ala 
65                  70                  75                  80  


Tyr Arg Asn His Gln Asp Val Ala Gly Val Phe Ala Leu Ser Ser Phe 
                85                  90                  95      


Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala Leu Gln Lys Ser Asn Gly 
            100                 105                 110         


Val Leu Pro Glu Leu Phe Gln Cys His Gly Thr Ala Asp Glu Leu Val 
        115                 120                 125             


Leu His Ser Trp Ala Glu Glu Thr Asn Ser Met Leu Lys Ser Leu Gly 
    130                 135                 140                 


Val Thr Thr Lys Phe His Ser Phe Pro Asn Val Tyr His Glu Leu Ser 
145                 150                 155                 160 


Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp Ile Leu Thr Lys Leu Pro 
                165                 170                 175     


Gly Glu Met Glu Lys Gln Lys 
            180             


<210>  7205
<211>  1764
<212>  DNA
<213>  Homosapiens

<400>  7205
aaaatgaggc cagacaggtt cagcagcttg gccaaggtct cttagctgtt actgtgattc     60

tggacaagga ttaagaatgt ggatcaagca ggttttaaat caagatttaa cattccaaca    120

cataaaaatt atttatccaa cagctcctcc cagatttaaa ataaccaatg actgcccaga    180

acaccttgaa tcaattgatg tcatgtgtca agtgcttact gatttgattg atgaagaagt    240

aaaaagtggc atcaagaaga acaggatatt aataggagga ttctctatgg gaggatgcat    300

ggcaatacat ttagcatata gaaatcatca agatgtggca ggagtatttg ctctttctag    360

ttttctgaat aaagcatctg ctgtttacca ggctcttcag aagagtaatg gtgtacttcc    420

tgaattattt cagtgtcatg gtactgcaga tgagttagtt cttcattctt gggcagaaga    480

gacaaactca atgttaaaat ctctaggagt gaccacgaag tttcatagtt ttccaaatgt    540

ttaccatgag ctaagcaaaa ctgagttaga catattgaag ttatggattc ttacaaagct    600

gccaggagaa atggaaaaac aaaaatgaat gaatcaagag tgatttgtta atgtaagtgt    660

aatgtctttg tgaaaagtga tttttactgc caaattataa tgataattaa aatattaaga    720

aataacactt tcctgacttt tttattatta aaatgcttat cactgtagac agtagctaat    780

cttattaatg aaaaacaata gacaaacatc tgtgcataat ttttcagaca caattctgta    840

aatatttgga aaccttttaa gtatttaaac ttttaaattt ttgaaataaa gtattctaaa    900

ctaatataaa taaggacaat gaaaaaacat gaaaggactt agcataatgt tattttatct    960

tttctacaac tttgtttaaa ttacctttcc aaagatattt gtgtttatgt aattttccac   1020

ggaataacat taatactcta ggtttataaa ccggtttcac attatttcat ttgatcatca   1080

caagagcttt gtgaagtaag ccgagaagtt gttactggta tttaataata gcaatagagg   1140

agttaaagac tttcccacag cttgcaggtc aagacaagaa attcaggtct cctaattctc   1200

agtggagctc tatttctgtt aacccaaatt gctgctctgt tttaggtctc aatttcatct   1260

gtaaaatgat actaatagta cttatcccat tggatttttg ttgagattta aataaatagc   1320

caaaagccaa tacataataa acactcaata aagattaacc ataaggagag tcatgatctg   1380

gttccaggaa tacattgtta gatgactgaa aaattgtatt acttcaatga aaatactata   1440

aataataaca ttttcatata ttagttggtt ctcatgcata cataatctaa ttttatttga   1500

tcctcacaac tgtttaagtt ttattaaata tacattatcc ctatttgtat aaatagaatc   1560

atacaatacc tgcctgcttt cattcaacaa aattatcatg agatttttcc atgttgtgta   1620

catcaatagt tcatctattt tattgctcag taatattcca ttgtgtggat gtatcactat   1680

ttgtttacac attcaccact gatatataag ttgcttccag tgtgaggctg ttttaaataa   1740

agctgctatg aatattcatg taag                                          1764


<210>  7206
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  7206

Met Trp Ile Lys Gln Val Leu Asn Gln Asp Leu Thr Phe Gln His Ile 
1               5                   10                  15      


Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg Phe Lys Ile Thr Asn Asp 
            20                  25                  30          


Cys Pro Glu His Leu Glu Ser Ile Asp Val Met Cys Gln Val Leu Thr 
        35                  40                  45              


Asp Leu Ile Asp Glu Glu Val Lys Ser Gly Ile Lys Lys Asn Arg Ile 
    50                  55                  60                  


Leu Ile Gly Gly Phe Ser Met Gly Gly Cys Met Ala Ile His Leu Ala 
65                  70                  75                  80  


Tyr Arg Asn His Gln Asp Val Ala Gly Val Phe Ala Leu Ser Ser Phe 
                85                  90                  95      


Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala Leu Gln Lys Ser Asn Gly 
            100                 105                 110         


Val Leu Pro Glu Leu Phe Gln Cys His Gly Thr Ala Asp Glu Leu Val 
        115                 120                 125             


Leu His Ser Trp Ala Glu Glu Thr Asn Ser Met Leu Lys Ser Leu Gly 
    130                 135                 140                 


Val Thr Thr Lys Phe His Ser Phe Pro Asn Val Tyr His Glu Leu Ser 
145                 150                 155                 160 


Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp Ile Leu Thr Lys Leu Pro 
                165                 170                 175     


Gly Glu Met Glu Lys Gln Lys 
            180             


<210>  7207
<211>  676
<212>  DNA
<213>  Homosapiens

<400>  7207
taaatttaac attcacttaa atatctattg ctgtttcttt tgggttcttc cagaataatt     60

ttttcttatt ctttacctta atttttaagg gtattcaaga agatctccat gtttataaaa    120

tctaagttaa ccatttctcc ccttttcatt ctgatgtata agtttacagc ccagaaatag    180

gttgctaaag ctatgtttta atattacgtg aatgcacaaa agatggagga ttctctatgg    240

gaggatgcat ggcaatacat ttagcatata gaaatcatca agatgtggca ggagtatttg    300

ctctttctag ttttctgaat aaagcatctg ctgtttacca ggctcttcag aagagtaatg    360

gtgtacttcc tgaattattt cagtgtcatg gtactgcaga tgagttagtt cttcattctt    420

gggcagaaga gacaaactca atgttaaaat ctctaggagt gaccacgaag tttcatagtt    480

ttccaaatgt ttaccatgag ctaagcaaaa ctgagttaga catattgaag ttatggattc    540

ttacaaagct gccaggagaa atggaaaaac aaaaatgaat gaatcaagag tgatttgtta    600

atgtaagtgt aatgtctttg tgaaaagtga tttttactgc caaattataa tgataattaa    660

aatattaaga aataac                                                    676


<210>  7208
<211>  113
<212>  PRT
<213>  Homosapiens

<400>  7208

Met Gly Gly Cys Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp 
1               5                   10                  15      


Val Ala Gly Val Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala 
            20                  25                  30          


Val Tyr Gln Ala Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe 
        35                  40                  45              


Gln Cys His Gly Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu 
    50                  55                  60                  


Glu Thr Asn Ser Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His 
65                  70                  75                  80  


Ser Phe Pro Asn Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile 
                85                  90                  95      


Leu Lys Leu Trp Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln 
            100                 105                 110         


Lys 
    


<210>  7209
<211>  1714
<212>  DNA
<213>  Homosapiens

<400>  7209
taaatttaac attcacttaa atatctattg ctgtttcttt tgggttcttc cagaataatt     60

ttttcttatt ctttacctta atttttaagg gtattcaaga agatctccat gtttataaaa    120

tctaagttaa ccatttctcc ccttttcatt ctgatgtata agtttacagc ccagaaatag    180

gttgctaaag ctatgtttta atattacgtg aatgcacaaa agatggagga ttctctatgg    240

gaggatgcat ggcaatacat ttagcatata gaaatcatca agatgtggca ggagtatttg    300

ctctttctag ttttctgaat aaagcatctg ctgtttacca ggctcttcag aagagtaatg    360

gtgtacttcc tgaattattt cagtgtcatg gtactgcaga tgagttagtt cttcattctt    420

gggcagaaga gacaaactca atgttaaaat ctctaggagt gaccacgaag tttcatagtt    480

ttccaaatgt ttaccatgag ctaagcaaaa ctgagttaga catattgaag ttatggattc    540

ttacaaagct gccaggagaa atggaaaaac aaaaatgaat gaatcaagag tgatttgtta    600

atgtaagtgt aatgtctttg tgaaaagtga tttttactgc caaattataa tgataattaa    660

aatattaaga aataacactt tcctgacttt tttattatta aaatgcttat cactgtagac    720

agtagctaat cttattaatg aaaaacaata gacaaacatc tgtgcataat ttttcagaca    780

caattctgta aatatttgga aaccttttaa gtatttaaac ttttaaattt ttgaaataaa    840

gtattctaaa ctaatataaa taaggacaat gaaaaaacat gaaaggactt agcataatgt    900

tattttatct tttctacaac tttgtttaaa ttacctttcc aaagatattt gtgtttatgt    960

aattttccac ggaataacat taatactcta ggtttataaa ccggtttcac attatttcat   1020

ttgatcatca caagagcttt gtgaagtaag ccgagaagtt gttactggta tttaataata   1080

gcaatagagg agttaaagac tttcccacag cttgcaggtc aagacaagaa attcaggtct   1140

cctaattctc agtggagctc tatttctgtt aacccaaatt gctgctctgt tttaggtctc   1200

aatttcatct gtaaaatgat actaatagta cttatcccat tggatttttg ttgagattta   1260

aataaatagc caaaagccaa tacataataa acactcaata aagattaacc ataaggagag   1320

tcatgatctg gttccaggaa tacattgtta gatgactgaa aaattgtatt acttcaatga   1380

aaatactata aataataaca ttttcatata ttagttggtt ctcatgcata cataatctaa   1440

ttttatttga tcctcacaac tgtttaagtt ttattaaata tacattatcc ctatttgtat   1500

aaatagaatc atacaatacc tgcctgcttt cattcaacaa aattatcatg agatttttcc   1560

atgttgtgta catcaatagt tcatctattt tattgctcag taatattcca ttgtgtggat   1620

gtatcactat ttgtttacac attcaccact gatatataag ttgcttccag tgtgaggctg   1680

ttttaaataa agctgctatg aatattcatg taag                               1714


<210>  7210
<211>  113
<212>  PRT
<213>  Homosapiens

<400>  7210

Met Gly Gly Cys Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp 
1               5                   10                  15      


Val Ala Gly Val Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala 
            20                  25                  30          


Val Tyr Gln Ala Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe 
        35                  40                  45              


Gln Cys His Gly Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu 
    50                  55                  60                  


Glu Thr Asn Ser Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His 
65                  70                  75                  80  


Ser Phe Pro Asn Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile 
                85                  90                  95      


Leu Lys Leu Trp Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln 
            100                 105                 110         


Lys 
    


<210>  7211
<211>  1114
<212>  DNA
<213>  Homosapiens

<400>  7211
gtgactggca tagaattggt acattaaaga gacaataaca gtttgactaa tttttttttc     60

aaactttggt tttaaaaact acatataggc atacatgttt catttttatt atatcaccat    120

aaattagttt ccaaaataat attgtaatcc aaaaatgtgt taactagctc ctcaaatttt    180

ttttatcatt cttaattcag aattcactaa gcatctatta tatagcaaac accagataca    240

taactcctta tggagctcac agcttagcaa gtaagacaaa aaggtgcaaa ttattaattg    300

cgttgcagtg tgagggtttc tgtacgtgta aacaaaatat aagtaaatat tgagaattta    360

agtaatgctt gtaatatgac tcattttgaa ttacgataga tattttactt ggtgaacatg    420

atatatttgt ttaatcctgg ctccttgtag agcacagctc tctttaccag tggtgacata    480

gagggaacag ggttatttat gttatcgcag gcctttgtct gtgaaactta gagtagacga    540

aatttctttt tagcattctc tttaaaggtc tccagatatt ttaaaaatat ggaaaattgt    600

tatatatcat atcctaaatt attattttat gtattctact tttaagtatg tttttgtttt    660

taggaggatt ctctatggga ggatgcatgg caatacattt agcatataga aatcatcaag    720

atgtggcagg agtatttgct ctttctagtt ttctgaataa agcatctgct gtttaccagg    780

ctcttcagaa gagtaatggt gtacttcctg aattatttca gtgtcatggt actgcagatg    840

agttagttct tcattcttgg gcagaagaga caaactcaat gttaaaatct ctaggagtga    900

ccacgaagtt tcatagtttt ccaaatgttt accatgagct aagcaaaact gagttagaca    960

tattgaagtt atggattctt acaaagctgc caggagaaat ggaaaaacaa aaatgaatga   1020

atcaagagtg atttgttaat gtaagtgtaa tgtctttgtg aaaagtgatt tttactgcca   1080

aattataatg ataattaaaa tattaagaaa taac                               1114


<210>  7212
<211>  122
<212>  PRT
<213>  Homosapiens

<400>  7212

Met Phe Leu Phe Leu Gly Gly Phe Ser Met Gly Gly Cys Met Ala Ile 
1               5                   10                  15      


His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val Phe Ala Leu 
            20                  25                  30          


Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala Leu Gln Lys 
        35                  40                  45              


Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly Thr Ala Asp 
    50                  55                  60                  


Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser Met Leu Lys 
65                  70                  75                  80  


Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn Val Tyr His 
                85                  90                  95      


Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp Ile Leu Thr 
            100                 105                 110         


Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
        115                 120         


<210>  7213
<211>  2152
<212>  DNA
<213>  Homosapiens

<400>  7213
gtgactggca tagaattggt acattaaaga gacaataaca gtttgactaa tttttttttc     60

aaactttggt tttaaaaact acatataggc atacatgttt catttttatt atatcaccat    120

aaattagttt ccaaaataat attgtaatcc aaaaatgtgt taactagctc ctcaaatttt    180

ttttatcatt cttaattcag aattcactaa gcatctatta tatagcaaac accagataca    240

taactcctta tggagctcac agcttagcaa gtaagacaaa aaggtgcaaa ttattaattg    300

cgttgcagtg tgagggtttc tgtacgtgta aacaaaatat aagtaaatat tgagaattta    360

agtaatgctt gtaatatgac tcattttgaa ttacgataga tattttactt ggtgaacatg    420

atatatttgt ttaatcctgg ctccttgtag agcacagctc tctttaccag tggtgacata    480

gagggaacag ggttatttat gttatcgcag gcctttgtct gtgaaactta gagtagacga    540

aatttctttt tagcattctc tttaaaggtc tccagatatt ttaaaaatat ggaaaattgt    600

tatatatcat atcctaaatt attattttat gtattctact tttaagtatg tttttgtttt    660

taggaggatt ctctatggga ggatgcatgg caatacattt agcatataga aatcatcaag    720

atgtggcagg agtatttgct ctttctagtt ttctgaataa agcatctgct gtttaccagg    780

ctcttcagaa gagtaatggt gtacttcctg aattatttca gtgtcatggt actgcagatg    840

agttagttct tcattcttgg gcagaagaga caaactcaat gttaaaatct ctaggagtga    900

ccacgaagtt tcatagtttt ccaaatgttt accatgagct aagcaaaact gagttagaca    960

tattgaagtt atggattctt acaaagctgc caggagaaat ggaaaaacaa aaatgaatga   1020

atcaagagtg atttgttaat gtaagtgtaa tgtctttgtg aaaagtgatt tttactgcca   1080

aattataatg ataattaaaa tattaagaaa taacactttc ctgacttttt tattattaaa   1140

atgcttatca ctgtagacag tagctaatct tattaatgaa aaacaataga caaacatctg   1200

tgcataattt ttcagacaca attctgtaaa tatttggaaa ccttttaagt atttaaactt   1260

ttaaattttt gaaataaagt attctaaact aatataaata aggacaatga aaaaacatga   1320

aaggacttag cataatgtta ttttatcttt tctacaactt tgtttaaatt acctttccaa   1380

agatatttgt gtttatgtaa ttttccacgg aataacatta atactctagg tttataaacc   1440

ggtttcacat tatttcattt gatcatcaca agagctttgt gaagtaagcc gagaagttgt   1500

tactggtatt taataatagc aatagaggag ttaaagactt tcccacagct tgcaggtcaa   1560

gacaagaaat tcaggtctcc taattctcag tggagctcta tttctgttaa cccaaattgc   1620

tgctctgttt taggtctcaa tttcatctgt aaaatgatac taatagtact tatcccattg   1680

gatttttgtt gagatttaaa taaatagcca aaagccaata cataataaac actcaataaa   1740

gattaaccat aaggagagtc atgatctggt tccaggaata cattgttaga tgactgaaaa   1800

attgtattac ttcaatgaaa atactataaa taataacatt ttcatatatt agttggttct   1860

catgcataca taatctaatt ttatttgatc ctcacaactg tttaagtttt attaaatata   1920

cattatccct atttgtataa atagaatcat acaatacctg cctgctttca ttcaacaaaa   1980

ttatcatgag atttttccat gttgtgtaca tcaatagttc atctatttta ttgctcagta   2040

atattccatt gtgtggatgt atcactattt gtttacacat tcaccactga tatataagtt   2100

gcttccagtg tgaggctgtt ttaaataaag ctgctatgaa tattcatgta ag           2152


<210>  7214
<211>  122
<212>  PRT
<213>  Homosapiens

<400>  7214

Met Phe Leu Phe Leu Gly Gly Phe Ser Met Gly Gly Cys Met Ala Ile 
1               5                   10                  15      


His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val Phe Ala Leu 
            20                  25                  30          


Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala Leu Gln Lys 
        35                  40                  45              


Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly Thr Ala Asp 
    50                  55                  60                  


Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser Met Leu Lys 
65                  70                  75                  80  


Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn Val Tyr His 
                85                  90                  95      


Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp Ile Leu Thr 
            100                 105                 110         


Lys Leu Pro Gly Glu Met Glu Lys Gln Lys 
        115                 120         


<210>  7215
<211>  1117
<212>  DNA
<213>  Homosapiens

<400>  7215
aactgacaag tgagaagatg agagggggga tgaatagatg ctgacataat gatattatat     60

ggagaaaaag tcatttttta aagatcacaa aaggagaagc aggttccagg atgaaccaca    120

aaaacagtaa ctcaacttct gtcctgggct ctttatatta aatctcacca gaaacccatt    180

ttacaggtgg gaaaagcttg gtccacctca gccttgggcc catgctttta tatctagtat    240

taacattcat tctggatgtg tagaagtctc tgccctcttt cagacaacag ttactgctat    300

ggtttgaatg tatgtgtccc tccaagatcc tcatgttgga atttaaaccc caaggtgatg    360

gtattaagag gtgaagcctt ttggaaagtg attaagtcat gatggctctg ccctcaagaa    420

tacattagtg ctcttataac agaagttgaa ggaacccccc tagtgccttt tgccttctcc    480

attccacaat gtgtggatat aacattctgc catatgagaa tttagcaaaa agacaccatc    540

ttgaagaaga gacaaccttc gccagacacc aaatctgctg gcactgtgct cttggacttc    600

cttatcaatt aatgattcta tggtattttg ttatagcaat gggaacagac taagacagtt    660

aaagagcgac acacttgcat tgagtgtaaa aggagggaaa cttacagtcc ttttaagcag    720

aaaccaagca agttgctaga cagctggctg gtacaactgg aagatgaggg gggtggtgtg    780

catgatggtt actaaggaaa aaccagcaac agagggactt ctcctaaagt ccatcatgcc    840

gaactttgat ccatttgaag atggcagtga aacacctcag aactttgttt tgttttcttt    900

acaactacgc atgcctgctt tcaagaagct ttggccctct cagggagatt tccctgagac    960

aaacaatttc ccatgggaaa caaaaaatgg gccttgatta gtattcaggg tcttattttt   1020

tagattgagt ttacaaagct gaagaggttg atgccctgaa gtgtgagaaa ctgacccctc   1080

aaaatcaaaa taaattcttg caagcagctg ccacatt                            1117


<210>  7216
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  7216

Met Arg Gly Val Val Cys Met Met Val Thr Lys Glu Lys Pro Ala Thr 
1               5                   10                  15      


Glu Gly Leu Leu Leu Lys Ser Ile Met Pro Asn Phe Asp Pro Phe Glu 
            20                  25                  30          


Asp Gly Ser Glu Thr Pro Gln Asn Phe Val Leu Phe Ser Leu Gln Leu 
        35                  40                  45              


Arg Met Pro Ala Phe Lys Lys Leu Trp Pro Ser Gln Gly Asp Phe Pro 
    50                  55                  60                  


Glu Thr Asn Asn Phe Pro Trp Glu Thr Lys Asn Gly Pro 
65                  70                  75          


<210>  7217
<211>  1028
<212>  DNA
<213>  Homosapiens

<400>  7217
gcaaaagatt cttcaaaatc aaactgtgtc cggaattggt gggttcttgg tctcactgac     60

ttcaagaatg aagccacgga ccctggcggt gagtgttaca gctcttaagg tggcgtttct    120

ggagtctgtc ccttctgatg ttcagatgtg ttcggagttt cttccttctg gtgggttcgt    180

ggtctcgctg gctcaggagt gaagctgcag atcttcacgg ttgctagtaa cacaataata    240

aagctgcttt attttccagt gaagatgtat gtgataggga gtggaggaag aaaaaggcca    300

gaaaattcca tagttagcaa atataccttt cttacttaaa attctttttc caatgtgagc    360

cttctaaaga gttactgaga aattaggtga gctcacctca tttaatgcaa tagatatgtt    420

tctgaaaaat aagcaataca taggacattg gccaattaag aattctgatg aagaagaatt    480

ttcacatccg aaagagtaaa aatgaaaaac ggtacaaatg tagtggcttt taaatttcaa    540

aacaaattat tttgataaga taaatattcc tctcataaag tgaaaatgga agagactgct    600

tgctgggtgt tcgtcaaaat ggagttagat ggtctgtccc agactcccct gttgttagtt    660

ctgagaacag aagtaatggt gcttcttcag gactggctca tagaaacctg ccgtgttcag    720

cccccacaat cctctccctt ctgctggctg gaaacaaatg acaacgaagc ctcacgtctt    780

ggagaaacca cactgctgag gaactcaagt cctagaagaa ccatttgaag agacccatct    840

cactaaagaa aatcacacaa gcaagaagta aacttcattg tatctatgta tttaattgtc    900

ataacagtct accttaactg atacagcaaa aattcgctcc ttttctggac acccagtttc    960

aaaatctcag tgtcattttt tacttctctc ttttcaggtt gtttaatata ataaaatttg   1020

tgtgtgtg                                                            1028


<210>  7218
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  7218

Met Glu Glu Thr Ala Cys Trp Val Phe Val Lys Met Glu Leu Asp Gly 
1               5                   10                  15      


Leu Ser Gln Thr Pro Leu Leu Leu Val Leu Arg Thr Glu Val Met Val 
            20                  25                  30          


Leu Leu Gln Asp Trp Leu Ile Glu Thr Cys Arg Val Gln Pro Pro Gln 
        35                  40                  45              


Ser Ser Pro Phe Cys Trp Leu Glu Thr Asn Asp Asn Glu Ala Ser Arg 
    50                  55                  60                  


Leu Gly Glu Thr Thr Leu Leu Arg Asn Ser Ser Pro Arg Arg Thr Ile 
65                  70                  75                  80  


<210>  7219
<211>  448
<212>  DNA
<213>  Homosapiens

<400>  7219
ggcattcaaa ggctgaaggg ccacctgaca ctccagaggc tgctggaaat gcagggctgt     60

ttcatcctgg gtattttcca gagagaagta ctgagaagct taaagtattt gaatgggagg    120

aggagaagca aactacagct acttcagagg ataacactaa acacctagtc cactctgtat    180

acactagagg tgctgttaat tttcttgtgg agaaggaact gtctttagaa aaatatctca    240

aaaagccact gaagtagaaa gtttcagcat gctgaagatg gaacttgaga agatagaaag    300

ttctgggtcc ttagtggcat gactgagtcg ctggaccact gttggaacca ccctatgtct    360

tagtttttaa atctctttac tgtctaagac atttttagtg gaagtattta tctctggcat    420

ccaataagac ctttaaggat ttgcagtt                                       448


<210>  7220
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  7220

Met Gln Gly Cys Phe Ile Leu Gly Ile Phe Gln Arg Glu Val Leu Arg 
1               5                   10                  15      


Ser Leu Lys Tyr Leu Asn Gly Arg Arg Arg Ser Lys Leu Gln Leu Leu 
            20                  25                  30          


Gln Arg Ile Thr Leu Asn Thr 
        35                  


<210>  7221
<211>  521
<212>  DNA
<213>  Homosapiens

<400>  7221
atggtactta caggagtaag gctcatgaag tggagagatg agaagacttt cgggacagat     60

tgtgtggagg ctgtcattct cctcgtgaca ttgctgtggg agaagaagga ggcattccat    120

gttggcttca gtgaagaact tcagtatttt ccagagagaa gtactgagaa gcttaaagta    180

tttgaatggg aggaggagaa gcaaactaca gctacttcag aggataacac taaacaccta    240

gtccactctg tatacactag aggtgctgtt aattttcttg tggagaagga actgtcttta    300

gaaaaatatc tcaaaaagcc actgaagtag aaagtttcag catgctgaag atggaacttg    360

agaagataga aagttctggg tccttagtgg catgactgag tcgctggacc actgttggaa    420

ccaccctatg tcttagtttt taaatctctt tactgtctaa gacattttta gtggaagtat    480

ttatctctgg catccaataa gacctttaag gatttgcagt t                        521


<210>  7222
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  7222

Met Val Leu Thr Gly Val Arg Leu Met Lys Trp Arg Asp Glu Lys Thr 
1               5                   10                  15      


Phe Gly Thr Asp Cys Val Glu Ala Val Ile Leu Leu Val Thr Leu Leu 
            20                  25                  30          


Trp Glu Lys Lys Glu Ala Phe His Val Gly Phe Ser Glu Glu Leu Gln 
        35                  40                  45              


Tyr Phe Pro Glu Arg Ser Thr Glu Lys Leu Lys Val Phe Glu Trp Glu 
    50                  55                  60                  


Glu Glu Lys Gln Thr Thr Ala Thr Ser Glu Asp Asn Thr Lys His Leu 
65                  70                  75                  80  


Val His Ser Val Tyr Thr Arg Gly Ala Val Asn Phe Leu Val Glu Lys 
                85                  90                  95      


Glu Leu Ser Leu Glu Lys Tyr Leu Lys Lys Pro Leu Lys 
            100                 105                 


<210>  7223
<211>  680
<212>  DNA
<213>  Homosapiens

<400>  7223
gggcacatgg gagcaccctc agctccctct ccatgggata ccctgtgggg cacttcagag     60

tccccaccag caagaaggct ctctctcacc agatgtgccc cccgccaacc ttggatgtct    120

cagtctccag aactcagatg agccagctcc cttgtgaagc tgtaagaaca tggtacttac    180

aggagtaagg ctcatgaagt ggagagatga gaagactttc gggacagatt gtgtggaggc    240

tgtcattctc ctcgtgacat tgctgtggga gaagaaggag gcattccatg ttggcttcag    300

tgaagaactt cagagaagga tggagcaaat gccccagatg aagcctacac gacatgagtc    360

agagaacttt ggccaggatg tctggggaaa aagtttcctc tttcttctct gggaactatc    420

tggagagggt tgttttaacg ctggatgtga acagcgactc gtgtagcccc agaagcctct    480

gacagccgcg ttggaatcat aagttctcaa aatgaaggat ttttttcttt cctttttagg    540

ttgtggtcta gaaagcatat tgtgatttgt acaagaagca cattcccatt ttacaaaagt    600

acaaaagcac attttggact tttaacaaat tcaactgttt tgtgttctgt gtgagtaaat    660

tttaggttgc ccatcattga                                                680


<210>  7224
<211>  98
<212>  PRT
<213>  Homosapiens

<400>  7224

Met Val Leu Thr Gly Val Arg Leu Met Lys Trp Arg Asp Glu Lys Thr 
1               5                   10                  15      


Phe Gly Thr Asp Cys Val Glu Ala Val Ile Leu Leu Val Thr Leu Leu 
            20                  25                  30          


Trp Glu Lys Lys Glu Ala Phe His Val Gly Phe Ser Glu Glu Leu Gln 
        35                  40                  45              


Arg Arg Met Glu Gln Met Pro Gln Met Lys Pro Thr Arg His Glu Ser 
    50                  55                  60                  


Glu Asn Phe Gly Gln Asp Val Trp Gly Lys Ser Phe Leu Phe Leu Leu 
65                  70                  75                  80  


Trp Glu Leu Ser Gly Glu Gly Cys Phe Asn Ala Gly Cys Glu Gln Arg 
                85                  90                  95      


Leu Val 
        


<210>  7225
<211>  723
<212>  DNA
<213>  Homosapiens

<400>  7225
agagctctat gttaagctaa aggagaaaca ccagggattt caccctcttc agagtgctgt     60

gaagtgggaa ataagatcat caactgaaca taaggatggg tgaggcttaa ggagagagaa    120

gcgctgaagt gggaaagtga aggcactacg gaaatgcaat ttctgattag cgttaagggg    180

ccacctgggg ttcaacaaca agcagactta agaacaaaag tgaagtggtg gcaaagtgct    240

ggaccagatg ttagaagtct ccaatttgct ctcgacaaca acaatccaca agtaaccctg    300

agaaaagtca tctctgtttc cccactggta aataatgaac atctcccaag gttaattttc    360

actggcccta aggggaggtg gtggaggacc actgagtcaa aagtgatcca aaagctcata    420

ccaggagaag atttttcaat tcagaacttg caactgatga ccggtgtaaa agtttggtga    480

ggcaaaagga tctaattatc cagacgtatc cacagagaga ggaaccagat gaaatgcgga    540

aagcacggtt caccttcaag agaaagaagt aggactctgg ggttttaagc cgaggcatga    600

aatgtaccga ttaatagcgt cattttgtaa ccacaggtct caggagtttt gggaaggtta    660

gtatgagctt gtcagcattg cttattaata acagtgagat tgctgctttg cacctgatct    720

cag                                                                  723


<210>  7226
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  7226

Met Gln Phe Leu Ile Ser Val Lys Gly Pro Pro Gly Val Gln Gln Gln 
1               5                   10                  15      


Ala Asp Leu Arg Thr Lys Val Lys Trp Trp Gln Ser Ala Gly Pro Asp 
            20                  25                  30          


Val Arg Ser Leu Gln Phe Ala Leu Asp Asn Asn Asn Pro Gln Val Thr 
        35                  40                  45              


Leu Arg Lys Val Ile Ser Val Ser Pro Leu Val Asn Asn Glu His Leu 
    50                  55                  60                  


Pro Arg Leu Ile Phe Thr Gly Pro Lys Gly Arg Trp Trp Arg Thr Thr 
65                  70                  75                  80  


Glu Ser Lys Val Ile Gln Lys Leu Ile Pro Gly Glu Asp Phe Ser Ile 
                85                  90                  95      


Gln Asn Leu Gln Leu Met Thr Gly Val Lys Val Trp 
            100                 105             


<210>  7227
<211>  4961
<212>  DNA
<213>  Homosapiens

<400>  7227
ggacgacgga cggcagcggc caagcaagaa gaaagacgtg gcagcaagcg ggagtcgggg     60

atagtgtcat cggttcgggt cccactactt tggagcttgt ctcaaactcc acatacagaa    120

agccaccaac cttattccgg tatcctacac ccattcccca ccctcattac actcccaccc    180

ctggccctca gcatgggagt caagagcaac agggacactt ccgtactcct tgtaggattg    240

gtgaaaccgt aatgaagaac acccctaaac tcccataatt ggatttgggg atattccctg    300

cccaaaaaat tcctggaaaa ttgactagta ttaagtctat ggaagatgga ttttttttca    360

tgatcctttg actctcaagt tcatctttaa atgaactctt ttttttgttt tgtttttgag    420

gagataacta acccttgctg tctccagtct gacaaaggtt atttgaatgg acttaatctc    480

ccagtagttg ggagatgttt taaaaacaca tgctgtgttt gaattgtggc tgagaggttt    540

tcttggcaat gtgaggagga aaattttttc tgcctcatta ttattaattc atggattgag    600

tgttggttcg acctacaggc ataatagatt ggaactcagt gaagacacag acgttcctgt    660

tgagagcaac cagctaatga ttacagttta aagacaattt ctgtgatcaa gttgtcattt    720

ggaagattaa acccatttca cgaggacttg gagcctggtc cttgctttga ggaagcagtg    780

gcttgtttca agaagccact tctgatctaa gaatctaccc agcatgccta atcaaggaga    840

agactgctat ttttttttct attctacatg taccaaaggt gacagctgcc cattccgtca    900

ctgtgaagct gcactaggca atgaaactgt ttgcacatta tggcaagaag ggcgctgttt    960

tcgacgggtg tgcaggtttc ggcacatgga gattgataaa aaacgcagtg aaattccttg   1020

ttattgggaa aatcagccaa caggatgtca aaaattaaac tgcgttttcc atcacaatag   1080

aggacgatat gttgatggcc ttttcctacc tccgagcaaa agtgtgttgc ccactgtgcc   1140

tgagtcacca gaagaggaag tgaaggctag ccaactttca gttcagcaga acaaattgtc   1200

tgtccagtcc aatacttccc ctcagctgcg gagcgttatg aaagtagaaa gttccgaaaa   1260

tgttcctagc cccaagcatc caccagttgt aattaatgct gcagatgatg atgaagatga   1320

tgatgatcag ttttctgagg aaggtgatga aaccaaaaca cctaccctgc aaccaactcc   1380

tgaagttcac aatggattac gagtgacttc tgtccggaaa cctgcagtca atataaagca   1440

aggtgaatgt ttgcattttg gaataaaaac tcttgaggaa attaagtcaa agaaaatgaa   1500

ggaaaaatct gaggagcaag gtgagggttc ttcaggagtt tccagtcttt tactccaccc   1560

tgagcctgtt ccaggtcctg aaaaagaaaa tgtcaggact gtggtgagga cagtaactct   1620

ctccaccaaa caaggagaag aacccttggt tagattgggc cttactgaga cactggggaa   1680

acgaaaattt tcgacaggcg gtgacagtga tcctccatta aagcgtagcc tggcacagag   1740

gctagggaag aaagttgaag ctccagaaac taacactgac gaaacaccaa agaaagctca   1800

agtttccaag tctcttaagg agcgattagg catgtcagct gatccaaata atgaggacgc   1860

aacagataaa gttaataaag ttggtgagat ccatgtgaag acattagaag aaatgcttct   1920

tgaaagagcc agtcagaaac atggggaatc gcaaactaaa ctcaagacag aaggaccttc   1980

aaaaactgat gattctactt caggagcaag aagctcctcc actatccgta tcaaaacctt   2040

ctctgaggtc ctggctgaag aagaacatag gcagcaggaa gcagagagac aaaaaagcaa   2100

aaaggataca acttgcatca agctaaagac tgatagtgaa attaaaaaaa cagtagtttt   2160

gccacccatt gttgccagca aaggacaatc agaggagcct gcaggtaaaa caaagtccat   2220

gcaggaggtg cacatgaaga cggtggaaga aattaaactg gagaaggcac tgagggtgca   2280

gcagagctct gagagcagca ccagctcccc gtctcaacat gaggccactc caggggcaag   2340

gttgctgctg cgaatcacca aaagaacatg gaggaaagaa gagaagaaac ttcaggaagg   2400

aaatgaagtt gattttctga gccgtgttag aatggaagct acagaggctt cagttgagac   2460

cacaggagtt gacatcacta aaattcaagt caagagatgt gagatcatga gagagacgcg   2520

catgcagaaa cagcaggaga gggaaaaatc agtcttgaca cctcttcagg gagatgtagc   2580

ctcttgcaat acccaagtgg cagagaaacc agtgctcact gctgtgccag gaatcacatg   2640

gcacctgacc aagcagcttc ccacaaagtc atcccagaag gtggaggtag aaacctcagg   2700

gattgcagac tcattattga atgtgaaatg gtcagcacag accttggaaa aaaggggtga   2760

agctaaaccc acagtgaacg tgaagcaatc tgtggttaaa gttgtgtcat cccccaaatt   2820

ggccccaaaa cgtaaggcag tggagatgca ccctgctgtc actgccgctg tgaagccact   2880

cagctccagc agcgtcctac aggaaccccc agccaaaaag gcagctgtgg atgctgttgt   2940

cctgcttgac tctgaggaca aatcagtcac tgtgcctgaa gcagaaaatc ctagagacag   3000

tcttgtgctg cctccaaccc agtcctcttc agattcctca cccccggagg tgtctggccc   3060

ttcctcatcc caaatgagca tgaaaactcg ccgactcagc tctgcctcaa caggaaagcc   3120

cccactctct gtggaggatg attttgagaa actaacatgg gagatttcag gaggcaaatt   3180

ggaagctgag attgacctgg atcctgggaa agatgaagat gaccttccgc ttgagctatg   3240

agaaatgatt gatagctgaa ggtggtagtg aggacacttt aaaaaaaaat cgccaaaaaa   3300

ctggacttag tttcatctat tgtaacattt acctgagatg atcatttctt tagtctagaa   3360

tttgccccaa atcagaagta tacctctgaa ttatctgtat gtgtcctgga ttccttgggg   3420

tcagattttt aaagttactt tataaccatt ttgtccattt gatgccattg tttatcatct   3480

tttgagaaaa aagttctgtc atacccttct ctccacaaaa aagagactga gggggagatc   3540

aagtgaaagg gtgcaagcaa acttagtgac tccttgaggt gtttgtcagt tttggctttt   3600

ttctcctttg ttgtattctt tatgtattgt cttaatgtac ttaatattac ctgagtttga   3660

aatggatgaa gacagctgct accattaagg gccaaatttt atgctaccac taaacaaaaa   3720

tacccactca gtctgtgtta aattgtatgt ctttttaaag gtatttagag attcaactaa   3780

gctttaaaga gggctgagca actcaggaag cctgtaatgt gggcataact ctttggacct   3840

gatcttgatg cttctgctgc tctgttggcc tctgaagagc aatatctaat ttattattac   3900

tgtaattttt taaaaggctt taaagtgcct caggggtccc ctgaaactaa ttttctattt   3960

ctgggattcc ctggattcat tatatgagat ggtgacatga ttagaggaat tcttttttag   4020

tatgaaaatt gttccttttc ttcttcagta cttgcctcct tgctggcatt gaattaacac   4080

agggacaaaa tttggttaat tttttatttc taattctccc aacaaacccc tgttgcccag   4140

tatttatgtg gtggccttta accacctgag ggaaaaaatg agcttattca agctgccaat   4200

atttatctat gggctgtagc agtacactga attgtactgt gccagggata ttgagatgct   4260

ctgggggtgt attgtatacc tgccagtttt cttcatttct gaattgggtt ttctcttctt   4320

gatgttggtt tccttcatat cacctcaagg tttagatttg tgaaggaata agcatgatgg   4380

aaataatagt cttgaaagga gatatgttgt atataatcag gaggaagagg aaggcaggac   4440

ttactcattt tgatattttg ctgtaggtgg ccagttttgt ttctcatagg gaaatctgac   4500

ccacctgtca tgttggctcc taaggaactg ctgttgtaag cggctcatca agagttgaac   4560

ttcaagtagc cttgttggga atatggaaaa ggaagaaagc cacaggactg cccattcagt   4620

cttgttaaga ttgggatgat tctgcacaag caaaaatgac tcgaaattta tgtatcgaca   4680

cacctctacc aatccatctt cagctgactg aatgttgtat gatagccctt ctccaaagca   4740

ggggtagaat gttcaggttt caccacggat tttctactta tttcgctttt ggaatcagct   4800

tacagattcc aggtcccttt tgtatatatt ctttattctt ttgctttttt aaaaaataaa   4860

cttgtattag tcaatgtttc gtgttccgca ttatttgaac catttgccct tacagaaaga   4920

gaaatacttg tttgtgtttt aaataaaact gatgtaggat a                       4961


<210>  7228
<211>  805
<212>  PRT
<213>  Homosapiens

<400>  7228

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Val Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Thr Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320 


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350         


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495     


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510         


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525             


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540                 


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560 


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575     


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590         


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605             


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620                 


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640 


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655     


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670         


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685             


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700                 


Val Val Leu Leu Asp Ser Glu Asp Lys Ser Val Thr Val Pro Glu Ala 
705                 710                 715                 720 


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Pro Thr Gln Ser Ser Ser 
                725                 730                 735     


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750         


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765             


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780                 


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800 


Leu Pro Leu Glu Leu 
                805 


<210>  7229
<211>  683
<212>  DNA
<213>  Homosapiens

<400>  7229
ctggcgctgt ggaggttcca atggccgcca tgttgtctca gagggacaca ccacaggctt     60

ctggaactct ggctccattt tgtgggtgca agtttctggc ttccgtttta aagagcaaga    120

gaacctatca gcgttgtcaa ttctaagaaa gtgagtgcca agagcaggct gtacaagaag    180

catggcacaa gaatctgctt ctgaagaggg cttcaggaag cttccactca tggtggaaaa    240

ggaaggagag caggtatcac agcgcaagaa agaagaaatt gttccactcc ataagttccc    300

tcctggagga tgtgtgagac accaggctgc atgttagaaa cggctgtgct ccggaaggct    360

accagggtca tcgtgagggc cttgcagatt tcagaaatga agtgacctgc cttgagtctt    420

ccctcagcct cctcactcca ctgtagtctc aggagagtga ggacaacaaa actctcttct    480

ccccacatta ccacttcagc gctgacctgt ggcttgagaa tctaatctgt gtgcaccgtg    540

gcaaagtctt ggttttacag gtctcacctg acagctagtc ctgatttttc catgatgtgt    600

gggtaaaaag tgggttcttg aagggaaacc tcaatgtagc ttagctcttg agaaaacagt    660

atgtgcatat gcttcttgga tag                                            683


<210>  7230
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  7230

Met Ala Gln Glu Ser Ala Ser Glu Glu Gly Phe Arg Lys Leu Pro Leu 
1               5                   10                  15      


Met Val Glu Lys Glu Gly Glu Gln Val Ser Gln Arg Lys Lys Glu Glu 
            20                  25                  30          


Ile Val Pro Leu His Lys Phe Pro Pro Gly Gly Cys Val Arg His Gln 
        35                  40                  45              


Ala Ala Cys 
    50      


<210>  7231
<211>  1960
<212>  DNA
<213>  Homosapiens

<400>  7231
ctcaaacttc cgcattccga atagctggga ctacaagtgt gcaccaccac ccccagctaa     60

cttttttctt cttttggata gagacagggt ctcactgtgt tgtccagacc ggtctctagc    120

tcctggcctt aagcaatcct cctgcattag cttctcaaat tgctggaatt tcaggcatga    180

gccaccgtgc ctggcctggg ctagtcctat attctctaga gttctcttta ctttgtgcta    240

gtcaatctct cattatgctg ttcacctgtt ataatgaata attctctgta ttaaatttta    300

ccactttaaa cttttgagtg gtttatgctt cctgattgga ctctgactaa tatgttagga    360

agggtcccag gagataaacc cacacagatg ggatttgggc agtgctgagc tctttgccag    420

tgggaaatgg gatgctggtg atttccagta ggtgacctca cagtgactca agctaccact    480

tactgttgat tgtgacgaaa tgccagctga ggcacatgcc ttgggagcta agtggttgct    540

gcacttgacc actgtgaaga ctggtgtggg aagaagggtc gtttctgatg cacttgagca    600

ggggtcccca acccctgagc catggagccg caaggagcca cacagcagga ggtgagtggt    660

gtcgagtgag ggagtgagga aagcttcgtc tgtatttaca gccactcccc tttgctcaca    720

ttcccgcctg agctccacct tctcagatca gcagcagcat tagattctca tagaacgcac    780

cctgttgtga accgtgcatg tgagggatct aggttgcgct gtccttaatg agagtctaat    840

acctattgat ctgtcacttc ctcccatcac gctcaggtgg gaccatccag ttgcaggaaa    900

acaagcttaa cacgcccact gattctacat tatgctccta cctcccggca gcctctccag    960

gcccagaact ttctccagtc agcctctaca gaccaagctc atgactcaca atggcctatt   1020

taggcccata ccctacctca cggcagtctc cgcagatgag cctactgcct cacaacagcc   1080

tccacaggca cagctccatc gttacaatgg cctctttaga cccagctcct gcctcccagc   1140

cttctctcca ggccctgaac tttctcaagt cgacctcacc aggcccagct catgcttctt   1200

tgcagcctct ccaggcccaa ctcctgcatc ttggtggccc ctccaggccc agcctgtgcc   1260

tcccgtcggc ctctacaatc ccaacatctg cctcacagca gattcttcac gcccagcctc   1320

tgcctcacag tggaccctcc agacccagat ggtgtctcac tgtggcatcc tcaggcgaag   1380

ctcctgcctt tcagcagcct ctccaggccc agctcctcct gcctcccagt ggcctctttc   1440

ggcccagccc agctcatgcc tcccggcggc cttcccaagc cccgcttttg acttttggtg   1500

gcctctgcag gcctcgacaa ggcccagcct cctgcctccc gaaggcctgc acaggcccag   1560

cctctgcctc acagcggact ctccacgccc agctagctct cgcctcactg cggcctcccc   1620

agtccaaagc tcctgccttt cggccacttc ggcaggtcca gctactgcct gccagtggcc   1680

tctttaggcc cagctcattc ctcacaacgg cctttccagg ccccgttttt cccttccggc   1740

agcctcttgg cttctaattt gtttatcttt tgtgtataaa tcccaaaata tggaattttg   1800

gaatatttcc accattatat attttggtcg gtaatttatt tggagtgagt ttctgcacca   1860

tgcccgaatt ttttatttta ttttccttat tatttggtgt taaacaggtt taatgacagt   1920

catggcaact ttttggcaca atgaaaaata tcgcccatga                         1960


<210>  7232
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  7232

Met Leu Leu Pro Pro Gly Ser Leu Ser Arg Pro Arg Thr Phe Ser Ser 
1               5                   10                  15      


Gln Pro Leu Gln Thr Lys Leu Met Thr His Asn Gly Leu Phe Arg Pro 
            20                  25                  30          


Ile Pro Tyr Leu Thr Ala Val Ser Ala Asp Glu Pro Thr Ala Ser Gln 
        35                  40                  45              


Gln Pro Pro Gln Ala Gln Leu His Arg Tyr Asn Gly Leu Phe Arg Pro 
    50                  55                  60                  


Ser Ser Cys Leu Pro Ala Phe Ser Pro Gly Pro Glu Leu Ser Gln Val 
65                  70                  75                  80  


Asp Leu Thr Arg Pro Ser Ser Cys Phe Phe Ala Ala Ser Pro Gly Pro 
                85                  90                  95      


Thr Pro Ala Ser Trp Trp Pro Leu Gln Ala Gln Pro Val Pro Pro Val 
            100                 105                 110         


Gly Leu Tyr Asn Pro Asn Ile Cys Leu Thr Ala Asp Ser Ser Arg Pro 
        115                 120                 125             


Ala Ser Ala Ser Gln Trp Thr Leu Gln Thr Gln Met Val Ser His Cys 
    130                 135                 140                 


Gly Ile Leu Arg Arg Ser Ser Cys Leu Ser Ala Ala Ser Pro Gly Pro 
145                 150                 155                 160 


Ala Pro Pro Ala Ser Gln Trp Pro Leu Ser Ala Gln Pro Ser Ser Cys 
                165                 170                 175     


Leu Pro Ala Ala Phe Pro Ser Pro Ala Phe Asp Phe Trp Trp Pro Leu 
            180                 185                 190         


Gln Ala Ser Thr Arg Pro Ser Leu Leu Pro Pro Glu Gly Leu His Arg 
        195                 200                 205             


Pro Ser Leu Cys Leu Thr Ala Asp Ser Pro Arg Pro Ala Ser Ser Arg 
    210                 215                 220                 


Leu Thr Ala Ala Ser Pro Val Gln Ser Ser Cys Leu Ser Ala Thr Ser 
225                 230                 235                 240 


Ala Gly Pro Ala Thr Ala Cys Gln Trp Pro Leu 
                245                 250     


<210>  7233
<211>  1254
<212>  DNA
<213>  Homosapiens

<400>  7233
gttgaccact gcagcagtaa agatgactct gaagaatggc gtgggatgga tcctttcaaa     60

tgcacttgag cagcagtctc caaccacagg gccacagagc tggagctgga tctaccatga    120

aagacttctg aatccaggaa gagagactga ctgggcaaca tgttattcag gtgggaccat    180

ccagttgcag gaaaacaagc ttaacacgcc cactgattct acattatgct cctacctccc    240

ggcagcctct ccaggcccag aactttctcc agtcagcctc tacagaccaa gctcatgact    300

cacaatggcc tatttaggcc cataccctac ctcacggcag tctccgcaga tgagcctact    360

gcctcacaac agcctccaca ggcacagctc catcgttaca atggcctctt tagacccagc    420

tcctgcctcc cagccttctc tccaggccct gaactttctc aagtcgacct caccaggccc    480

agctcatgct tctttgcagc ctctccaggc ccaactcctg catcttggtg gcccctccag    540

gcccagcctg tgcctcccgt cggcctctac aatcccaaca tctgcctcac agcagattct    600

tcacgcccag cctctgcctc acagtggacc ctccagaccc agatggtgtc tcactgtggc    660

atcctcaggc gaagctcctg cctttcagca gcctctccag gcccagctcc tcctgcctcc    720

cagtggcctc tttcggccca gcccagctca tgcctcccgg cggccttccc aagccccgct    780

tttgactttt ggtggcctct gcaggcctcg acaaggccca gcctcctgcc tcccgaaggc    840

ctgcacaggc ccagcctctg cctcacagcg gactctccac gcccagctag ctctcgcctc    900

actgcggcct ccccagtcca aagctcctgc ctttcggcca cttcggcagg tccagctact    960

gcctgccagt ggcctcttta ggcccagctc attcctcaca acggcctttc caggccccgt   1020

ttttcccttc cggcagcctc ttggcttcta atttgtttat cttttgtgta taaatcccaa   1080

aatatggaat tttggaatat ttccaccatt atatattttg gtcggtaatt tatttggagt   1140

gagtttctgc accatgcccg aattttttat tttattttcc ttattatttg gtgttaaaca   1200

ggtttaatga cagtcatggc aactttttgg cacaatgaaa aatatcgccc atga         1254


<210>  7234
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  7234

Met Leu Leu Pro Pro Gly Ser Leu Ser Arg Pro Arg Thr Phe Ser Ser 
1               5                   10                  15      


Gln Pro Leu Gln Thr Lys Leu Met Thr His Asn Gly Leu Phe Arg Pro 
            20                  25                  30          


Ile Pro Tyr Leu Thr Ala Val Ser Ala Asp Glu Pro Thr Ala Ser Gln 
        35                  40                  45              


Gln Pro Pro Gln Ala Gln Leu His Arg Tyr Asn Gly Leu Phe Arg Pro 
    50                  55                  60                  


Ser Ser Cys Leu Pro Ala Phe Ser Pro Gly Pro Glu Leu Ser Gln Val 
65                  70                  75                  80  


Asp Leu Thr Arg Pro Ser Ser Cys Phe Phe Ala Ala Ser Pro Gly Pro 
                85                  90                  95      


Thr Pro Ala Ser Trp Trp Pro Leu Gln Ala Gln Pro Val Pro Pro Val 
            100                 105                 110         


Gly Leu Tyr Asn Pro Asn Ile Cys Leu Thr Ala Asp Ser Ser Arg Pro 
        115                 120                 125             


Ala Ser Ala Ser Gln Trp Thr Leu Gln Thr Gln Met Val Ser His Cys 
    130                 135                 140                 


Gly Ile Leu Arg Arg Ser Ser Cys Leu Ser Ala Ala Ser Pro Gly Pro 
145                 150                 155                 160 


Ala Pro Pro Ala Ser Gln Trp Pro Leu Ser Ala Gln Pro Ser Ser Cys 
                165                 170                 175     


Leu Pro Ala Ala Phe Pro Ser Pro Ala Phe Asp Phe Trp Trp Pro Leu 
            180                 185                 190         


Gln Ala Ser Thr Arg Pro Ser Leu Leu Pro Pro Glu Gly Leu His Arg 
        195                 200                 205             


Pro Ser Leu Cys Leu Thr Ala Asp Ser Pro Arg Pro Ala Ser Ser Arg 
    210                 215                 220                 


Leu Thr Ala Ala Ser Pro Val Gln Ser Ser Cys Leu Ser Ala Thr Ser 
225                 230                 235                 240 


Ala Gly Pro Ala Thr Ala Cys Gln Trp Pro Leu 
                245                 250     


<210>  7235
<211>  942
<212>  DNA
<213>  Homosapiens

<400>  7235
gagtctaata cctattgatc tgtcacttcc tcccatcacg ctcaggtggg accatccagt     60

tgcaggaaaa caagcttaac acgcccactg attctacatt atggtgaatt ctataattat    120

tttattatat attacagtgt aataatggaa atgaagtgcc taataaatgt gaatgtgctt    180

aaatcttttg gcccagctcc tacctcccgg cagcctctcc aggcccagaa ctttctccag    240

tcagcctcta cagaccaagc tcatgactca caatggccta tttaggccca taccctacct    300

cacggcagtc tccgcagatg agcctactgc ctcacaacag cctccacagg cacagctcca    360

tcgttacaat ggcctcttta gacccagctc ctgcctccca gccttctctc caggccctga    420

actttctcaa gtcgacctca ccaggcccag ctcatgcttc tttgcagcct ctccaggccc    480

aactcctgca tcttggtggc ccctccaggc ccagcctctc ctcctgcctc ccagtggcct    540

ctttcggccc agcccagctc atgcctcccg gcggccttcc caagccccgc ttttgacttt    600

tggtggcctc tgcaggcctc gacaaggccc agcctcctgc ctcccgaagg cctgcacagg    660

cccagcctct gcctcacagc ggactctcca cgcccagcta gctctcgcct cactgcggcc    720

tccccagtcc aaagctcctg cctttcggcc acttcggcag gtccagctac tgcctgccag    780

tggcctcttt aggcccagct cattcctcac aacggccttt ccaggccccg tttttccctt    840

ccggcagcct cttggcttct aatttgttta tcttttgtgt ataaatccca aaatatggaa    900

ttttggaata tttccaccat tatatatttt ggtcggtaat tt                       942


<210>  7236
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  7236

Met Cys Leu Asn Leu Leu Ala Gln Leu Leu Pro Pro Gly Ser Leu Ser 
1               5                   10                  15      


Arg Pro Arg Thr Phe Ser Ser Gln Pro Leu Gln Thr Lys Leu Met Thr 
            20                  25                  30          


His Asn Gly Leu Phe Arg Pro Ile Pro Tyr Leu Thr Ala Val Ser Ala 
        35                  40                  45              


Asp Glu Pro Thr Ala Ser Gln Gln Pro Pro Gln Ala Gln Leu His Arg 
    50                  55                  60                  


Tyr Asn Gly Leu Phe Arg Pro Ser Ser Cys Leu Pro Ala Phe Ser Pro 
65                  70                  75                  80  


Gly Pro Glu Leu Ser Gln Val Asp Leu Thr Arg Pro Ser Ser Cys Phe 
                85                  90                  95      


Phe Ala Ala Ser Pro Gly Pro Thr Pro Ala Ser Trp Trp Pro Leu Gln 
            100                 105                 110         


Ala Gln Pro Leu Leu Leu Pro Pro Ser Gly Leu Phe Arg Pro Ser Pro 
        115                 120                 125             


Ala His Ala Ser Arg Arg Pro Ser Gln Ala Pro Leu Leu Thr Phe Gly 
    130                 135                 140                 


Gly Leu Cys Arg Pro Arg Gln Gly Pro Ala Ser Cys Leu Pro Lys Ala 
145                 150                 155                 160 


Cys Thr Gly Pro Ala Ser Ala Ser Gln Arg Thr Leu His Ala Gln Leu 
                165                 170                 175     


Ala Leu Ala Ser Leu Arg Pro Pro Gln Ser Lys Ala Pro Ala Phe Arg 
            180                 185                 190         


Pro Leu Arg Gln Val Gln Leu Leu Pro Ala Ser Gly Leu Phe Arg Pro 
        195                 200                 205             


Ser Ser Phe Leu Thr Thr Ala Phe Pro Gly Pro Val Phe Pro Phe Arg 
    210                 215                 220                 


Gln Pro Leu Gly Phe 
225                 


<210>  7237
<211>  1837
<212>  DNA
<213>  Homosapiens

<400>  7237
ctcaaacttc cgcattccga atagctggga ctacaagtgt gcaccaccac ccccagctaa     60

cttttttctt cttttggata gagacagggt ctcactgtgt tgtccagacc ggtctctagc    120

tcctggcctt aagcaatcct cctgcattag cttctcaaat tgctggaatt tcaggcatga    180

gccaccgtgc ctggcctggg ctagtcctat attctctaga gttctcttta ctttgtgcta    240

gtcaatctct cattatgctg ttcacctgtt ataatgaata attctctgta ttaaatttta    300

ccactttaaa cttttgagtg gtttatgctt cctgattgga ctctgactaa tatgttagga    360

agggtcccag gagataaacc cacacagatg ggatttgggc agtgctgagc tctttgccag    420

tgggaaatgg gatgctggtg atttccagta ggtgacctca cagtgactca agctaccact    480

tactgttgat tgtgacgaaa tgccagctga ggcacatgcc ttgggagcta agtggttgct    540

gcacttgacc actgtgaaga ctggtgtggg aagaagggtc gtttctgatg cacttgagca    600

ggggtcccca acccctgagc catggagccg caaggagcca cacagcagga ggtgagtggt    660

gtcgagtgag ggagtgagga aagcttcgtc tgtatttaca gccactcccc tttgctcaca    720

ttcccgcctg agctccacct tctcagatca gcagcagcat tagattctca tagaacgcac    780

cctgttgtga accgtgcatg tgagggatct aggttgcgct gtccttaatg agagtctaat    840

acctattgat ctgtcacttc ctcccatcac gctcaggtgg gaccatccag ttgcaggaaa    900

acaagcttaa cacgcccact gattctacat tatgctccta cctcccggca gcctctccag    960

gcccagaact ttctccagtc agcctctaca gaccaagctc atgactcaca atggcctatt   1020

taggcccata ccctacctca cggcagtctc cgcagatgag cctactgcct cacaacagcc   1080

tccacaggca cagctccatc gttacaatgg cctctttaga cccagctcct gcctcccagc   1140

cttctctcca ggccctgaac tttctcaagt cgacctcacc aggcccagct catgcttctt   1200

tgcagcctct ccaggcccaa ctcctgcatc ttggtggccc ctccaggccc agcctgtgcc   1260

tcccgtcggc ctctacaatc ccaacatctg cctcacagca gattcttcac gcccagcctc   1320

tgcctcacag tggaccctcc agacccagat ggtgtctcac tgtggcatcc tcaggcgaag   1380

ctcctgcctt tcagcagcct ctccaggccc agctcctcct gcctcccagt ggcctctttc   1440

ggcccagccc agctcatgcc tcccggcggc cttcccaagc cccgcttttg acttttggtg   1500

gcctctgcag gcctcgacaa ggcccagcct cctgcctccc gaaggcctgc acaggcccag   1560

cctctgcctc acagcggact ctccacgccc agctagctct cgcctcactg cggcctcccc   1620

agtccaaagc tcctgccttt cggccacttc ggcaggtcca gctactgcct gccagtggcc   1680

tctttaggcc cagctcattc ctcacaacgg cctttccagg ccccgttttt cccttccggc   1740

agcctcttgg cttctaattt gtttatcttt tgtgtataaa tcccaaaata tggaattttg   1800

gaatatttcc accattatat attttggtcg gtaattt                            1837


<210>  7238
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  7238

Met Leu Leu Pro Pro Gly Ser Leu Ser Arg Pro Arg Thr Phe Ser Ser 
1               5                   10                  15      


Gln Pro Leu Gln Thr Lys Leu Met Thr His Asn Gly Leu Phe Arg Pro 
            20                  25                  30          


Ile Pro Tyr Leu Thr Ala Val Ser Ala Asp Glu Pro Thr Ala Ser Gln 
        35                  40                  45              


Gln Pro Pro Gln Ala Gln Leu His Arg Tyr Asn Gly Leu Phe Arg Pro 
    50                  55                  60                  


Ser Ser Cys Leu Pro Ala Phe Ser Pro Gly Pro Glu Leu Ser Gln Val 
65                  70                  75                  80  


Asp Leu Thr Arg Pro Ser Ser Cys Phe Phe Ala Ala Ser Pro Gly Pro 
                85                  90                  95      


Thr Pro Ala Ser Trp Trp Pro Leu Gln Ala Gln Pro Val Pro Pro Val 
            100                 105                 110         


Gly Leu Tyr Asn Pro Asn Ile Cys Leu Thr Ala Asp Ser Ser Arg Pro 
        115                 120                 125             


Ala Ser Ala Ser Gln Trp Thr Leu Gln Thr Gln Met Val Ser His Cys 
    130                 135                 140                 


Gly Ile Leu Arg Arg Ser Ser Cys Leu Ser Ala Ala Ser Pro Gly Pro 
145                 150                 155                 160 


Ala Pro Pro Ala Ser Gln Trp Pro Leu Ser Ala Gln Pro Ser Ser Cys 
                165                 170                 175     


Leu Pro Ala Ala Phe Pro Ser Pro Ala Phe Asp Phe Trp Trp Pro Leu 
            180                 185                 190         


Gln Ala Ser Thr Arg Pro Ser Leu Leu Pro Pro Glu Gly Leu His Arg 
        195                 200                 205             


Pro Ser Leu Cys Leu Thr Ala Asp Ser Pro Arg Pro Ala Ser Ser Arg 
    210                 215                 220                 


Leu Thr Ala Ala Ser Pro Val Gln Ser Ser Cys Leu Ser Ala Thr Ser 
225                 230                 235                 240 


Ala Gly Pro Ala Thr Ala Cys Gln Trp Pro Leu 
                245                 250     


<210>  7239
<211>  1131
<212>  DNA
<213>  Homosapiens

<400>  7239
gttgaccact gcagcagtaa agatgactct gaagaatggc gtgggatgga tcctttcaaa     60

tgcacttgag cagcagtctc caaccacagg gccacagagc tggagctgga tctaccatga    120

aagacttctg aatccaggaa gagagactga ctgggcaaca tgttattcag gtgggaccat    180

ccagttgcag gaaaacaagc ttaacacgcc cactgattct acattatgct cctacctccc    240

ggcagcctct ccaggcccag aactttctcc agtcagcctc tacagaccaa gctcatgact    300

cacaatggcc tatttaggcc cataccctac ctcacggcag tctccgcaga tgagcctact    360

gcctcacaac agcctccaca ggcacagctc catcgttaca atggcctctt tagacccagc    420

tcctgcctcc cagccttctc tccaggccct gaactttctc aagtcgacct caccaggccc    480

agctcatgct tctttgcagc ctctccaggc ccaactcctg catcttggtg gcccctccag    540

gcccagcctg tgcctcccgt cggcctctac aatcccaaca tctgcctcac agcagattct    600

tcacgcccag cctctgcctc acagtggacc ctccagaccc agatggtgtc tcactgtggc    660

atcctcaggc gaagctcctg cctttcagca gcctctccag gcccagctcc tcctgcctcc    720

cagtggcctc tttcggccca gcccagctca tgcctcccgg cggccttccc aagccccgct    780

tttgactttt ggtggcctct gcaggcctcg acaaggccca gcctcctgcc tcccgaaggc    840

ctgcacaggc ccagcctctg cctcacagcg gactctccac gcccagctag ctctcgcctc    900

actgcggcct ccccagtcca aagctcctgc ctttcggcca cttcggcagg tccagctact    960

gcctgccagt ggcctcttta ggcccagctc attcctcaca acggcctttc caggccccgt   1020

ttttcccttc cggcagcctc ttggcttcta atttgtttat cttttgtgta taaatcccaa   1080

aatatggaat tttggaatat ttccaccatt atatattttg gtcggtaatt t            1131


<210>  7240
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  7240

Met Leu Leu Pro Pro Gly Ser Leu Ser Arg Pro Arg Thr Phe Ser Ser 
1               5                   10                  15      


Gln Pro Leu Gln Thr Lys Leu Met Thr His Asn Gly Leu Phe Arg Pro 
            20                  25                  30          


Ile Pro Tyr Leu Thr Ala Val Ser Ala Asp Glu Pro Thr Ala Ser Gln 
        35                  40                  45              


Gln Pro Pro Gln Ala Gln Leu His Arg Tyr Asn Gly Leu Phe Arg Pro 
    50                  55                  60                  


Ser Ser Cys Leu Pro Ala Phe Ser Pro Gly Pro Glu Leu Ser Gln Val 
65                  70                  75                  80  


Asp Leu Thr Arg Pro Ser Ser Cys Phe Phe Ala Ala Ser Pro Gly Pro 
                85                  90                  95      


Thr Pro Ala Ser Trp Trp Pro Leu Gln Ala Gln Pro Val Pro Pro Val 
            100                 105                 110         


Gly Leu Tyr Asn Pro Asn Ile Cys Leu Thr Ala Asp Ser Ser Arg Pro 
        115                 120                 125             


Ala Ser Ala Ser Gln Trp Thr Leu Gln Thr Gln Met Val Ser His Cys 
    130                 135                 140                 


Gly Ile Leu Arg Arg Ser Ser Cys Leu Ser Ala Ala Ser Pro Gly Pro 
145                 150                 155                 160 


Ala Pro Pro Ala Ser Gln Trp Pro Leu Ser Ala Gln Pro Ser Ser Cys 
                165                 170                 175     


Leu Pro Ala Ala Phe Pro Ser Pro Ala Phe Asp Phe Trp Trp Pro Leu 
            180                 185                 190         


Gln Ala Ser Thr Arg Pro Ser Leu Leu Pro Pro Glu Gly Leu His Arg 
        195                 200                 205             


Pro Ser Leu Cys Leu Thr Ala Asp Ser Pro Arg Pro Ala Ser Ser Arg 
    210                 215                 220                 


Leu Thr Ala Ala Ser Pro Val Gln Ser Ser Cys Leu Ser Ala Thr Ser 
225                 230                 235                 240 


Ala Gly Pro Ala Thr Ala Cys Gln Trp Pro Leu 
                245                 250     


<210>  7241
<211>  543
<212>  DNA
<213>  Homosapiens

<400>  7241
cctgtggttg gagactgctg ctcaagtgca tttgaaagga tccatcccac gccattcttc     60

agagtcatct ttactgctgc agtggtcaac ttgtagcacc cccaagctcg caggacatat    120

gcttcaactg gcatttcaca atcaacacta tgtggcagct tgagtcattg tgagctcact    180

tcctgtaatc ccagctactc gggaggctga ggcaggagca ttgcttgagc ctggcaggtg    240

gaggctgcag tgagcagagg ttgtgccact gtactccagc ctgtagtccc agctactggg    300

aaggctgaca tggtaggatt gcttgagcct gggagtttga ggctataatg agccatgata    360

ggaccactga actccatcct gagtgacagg gcaaggtcct gtttcttgtc ctgtgcatct    420

ctttcattgg ctgttcctga gatggagcca ttacattgag ccagtaattg aaaataaggt    480

ggccagatgc gctggctcat gcccgtaatc ccagcactgt gggaggcaga ggtgggtgga    540

atc                                                                  543


<210>  7242
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  7242

Met Ile Gly Pro Leu Asn Ser Ile Leu Ser Asp Arg Ala Arg Ser Cys 
1               5                   10                  15      


Phe Leu Ser Cys Ala Ser Leu Ser Leu Ala Val Pro Glu Met Glu Pro 
            20                  25                  30          


Leu His 
        


<210>  7243
<211>  332
<212>  DNA
<213>  Homosapiens

<400>  7243
aatgacatct tatcaagatg gataaaccct agtttcccag tgctggaata tagaaaatgg     60

atggacaagt aaatcccact cagcacccat agtccaggca tggggacctc aacacacctg    120

agcaccagac atcacctttc attctggacc taccatgaaa gacttctgaa tccaggaaga    180

gaaactgact gggcaacatg ttattcaggt acaaaaagac ttggactgta actcaaaaat    240

gatcaaataa tagtgcatgc atcaagtgca atcggaagct cttctggaga gggagagaag    300

cttccagtta aggtgacatt gaagccaagt cc                                  332


<210>  7244
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  7244

Met Gly Thr Ser Thr His Leu Ser Thr Arg His His Leu Ser Phe Trp 
1               5                   10                  15      


Thr Tyr His Glu Arg Leu Leu Asn Pro Gly Arg Glu Thr Asp Trp Ala 
            20                  25                  30          


Thr Cys Tyr Ser Gly Thr Lys Arg Leu Gly Leu 
        35                  40              


<210>  7245
<211>  810
<212>  DNA
<213>  Homosapiens

<400>  7245
ggctgcgtca ctggggcgct atggtgcctg gagctgggca gttttctcgt cagagtgggg     60

actggtaaga gcgacctccc cgccaggtcc tgtgtgttgc cggctgaaga agggtagctg    120

aaaaattcag acccagcaca gtgtttatgt tggtcaaaaa tagaaaacta tgtctggcgc    180

ggccgaggcg ggaggaccct tcaggccaag agcagcgtag caacatggcg caaccccatc    240

tctgtagtcc tacctcagcc ccccagctac ttgaacccaa aggttcaagg ctccagtgag    300

ctatgatccc accacagcat tccagcctgc gagattgaga tgatgattat tccccacctt    360

ctaagagaca aagaccaacg agccaccaca gccaccagtc ccagaacccg ccaatgctgg    420

ggaacggaaa atgagggagt tcaactctga gaaatggaat catcgtatcg ctgatctacg    480

taaacaaact gaagaattgt ctgaaagaaa atatgacatg aacttatgaa ttcaacaggt    540

gaagatttac aacttgataa atcaactttg tgagctcgag ctgtaaaagc caaaggtctg    600

gtgatgatcc catacccttt tttccagtct catgttgaag atttttatgt agaaggcctt    660

cccaaaggaa tttttttttt tttttttttt tgagatggag ttttcactct tatcgcccag    720

gctggggtgc aatggcgcaa ccttgctggt cactgcaacc tctgcctcct gggttcaaga    780

aattctcctg ccttagcctc ccaagtcgct                                     810


<210>  7246
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  7246

Met Met Ile Ile Pro His Leu Leu Arg Asp Lys Asp Gln Arg Ala Thr 
1               5                   10                  15      


Thr Ala Thr Ser Pro Arg Thr Arg Gln Cys Trp Gly Thr Glu Asn Glu 
            20                  25                  30          


Gly Val Gln Leu 
        35      


<210>  7247
<211>  886
<212>  DNA
<213>  Homosapiens

<400>  7247
caggagcgcg catgagcgga cgctgcctac gggtggccgg gcgggatgta accggctgct     60

gagctggcag ttctgtgtcg ctaggcttct gcccggccgc cgccgcacat aagctgcgag    120

gaggagcttt acgacttccc ggtcttcggg gccgggcgca gcaagggcca gactctgcgc    180

tagcaggcgc tgcgcgccaa ccggccggca cctgtcgcag aaggtgcaac cgatcgcact    240

gtcgcgcaga agctcctcaa tggccagcgc cagctgcagc cccggccgcc cactcgcctc    300

atctgagcct ggctggcagc ctgctatcaa ttacattgat agtaaatttg aggactacct    360

aaatgcagaa tcgcaagtga acagatgtca gatgcctggt aacagggtgc agtgttgttt    420

atacttcatt gctccttcag gacatggctc tgttcacgga aagggcctgg gagctgcaac    480

acctcaacag caacgagcac acctgctacc tagaacttgg tttctaaaaa ccatcctcct    540

ctaaaaggaa acagagctct ttgaagaaat gagacagatc tcattatgtt gcccagggtg    600

atccttgatc tcctggcctc aagtgatcct ccaaccttgg tctcccaaag tgctgggatt    660

acagatgtga actaccacac ccagtcaacg tgcagaaggt tttcagtttg atgtagtctg    720

atgtagtctc atgtatttat ccttgttgtt gttgcctgag cttttggtgt gatatccaaa    780

aatatcattg ccaagatcaa tatcaagaaa ctttccccct atgtttctta cagaaatttt    840

atggtttcag atttttcatc tattttgagt atatttttgt gtatga                   886


<210>  7248
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  7248

Met Ala Ser Ala Ser Cys Ser Pro Gly Arg Pro Leu Ala Ser Ser Glu 
1               5                   10                  15      


Pro Gly Trp Gln Pro Ala Ile Asn Tyr Ile Asp Ser Lys Phe Glu Asp 
            20                  25                  30          


Tyr Leu Asn Ala Glu Ser Gln Val Asn Arg Cys Gln Met Pro Gly Asn 
        35                  40                  45              


Arg Val Gln Cys Cys Leu Tyr Phe Ile Ala Pro Ser Gly His Gly Ser 
    50                  55                  60                  


Val His Gly Lys Gly Leu Gly Ala Ala Thr Pro Gln Gln Gln Arg Ala 
65                  70                  75                  80  


His Leu Leu Pro Arg Thr Trp Phe Leu Lys Thr Ile Leu Leu 
                85                  90                  


<210>  7249
<211>  424
<212>  DNA
<213>  Homosapiens

<400>  7249
aggagcgcgc atgagcggac gctgcctacg ggtggccggg cgggatgtaa ccggctgctg     60

agctggcagt tctgtgtcgc taggcttctg cccggccgcc gccgcacata agctgcgagg    120

aggagcttta cgacttcccg gtcttcgggg ccgggcgcag caagggccag actctgcgct    180

agcaggcgct gcgcgccaac cggccggcac ctgtcgcaga aggtgcaacc gatcgcactg    240

tcgcgcagaa gctcctcaat ggccagcgcc agctgcagcc ccggccgccc actcgcctca    300

tctgagcctg ggcgaatctg gattgggaaa gttgatatta atcaactcat tattcctcac    360

agatttgtat tctccagagt atccaggtcc ttctcagaga attaaaaagc ctgtacaggt    420

ctac                                                                 424


<210>  7250
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  7250

Met Ala Ser Ala Ser Cys Ser Pro Gly Arg Pro Leu Ala Ser Ser Glu 
1               5                   10                  15      


Pro Gly Arg Ile Trp Ile Gly Lys Val Asp Ile Asn Gln Leu Ile Ile 
            20                  25                  30          


Pro His Arg Phe Val Phe Ser Arg Val Ser Arg Ser Phe Ser Glu Asn 
        35                  40                  45              


<210>  7251
<211>  566
<212>  DNA
<213>  Homosapiens

<400>  7251
aggagcgcgc atgagcggac gctgcctacg ggtggccggg cgggatgtaa ccggctgctg     60

agctggcagt tctgtgtcgc taggcttctg cccggccgcc gccgcacata agctgcgagg    120

aggagcttta cgacttcccg gtcttcgggg ccgggcgcag caagggccag actctgcgct    180

agcaggcgct gcgcgccaac cggccggcac ctgtcgcaga aggtgcaacc gatcgcactg    240

tcgcgcagaa gctcctcaat ggccagcgcc agctgcagcc ccggccgccc actcgcctca    300

tctgagcctg ggcgaatctg gattgggaaa gttgatatta atcaactcat tattcctcac    360

agatttgtat tctccagagt atccaggtcc ttctcagaga attaaaaagc ctgtacaggt    420

ctacatattg gtatttttaa ttgatgataa gctggaataa tattaataca cacaaagcac    480

gtgttgtaac tttcattatg cttccctaga ggtaagatgc aaatttgccc ttagccagtg    540

taagatggta aatatgactt cataaa                                         566


<210>  7252
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  7252

Met Ala Ser Ala Ser Cys Ser Pro Gly Arg Pro Leu Ala Ser Ser Glu 
1               5                   10                  15      


Pro Gly Arg Ile Trp Ile Gly Lys Val Asp Ile Asn Gln Leu Ile Ile 
            20                  25                  30          


Pro His Arg Phe Val Phe Ser Arg Val Ser Arg Ser Phe Ser Glu Asn 
        35                  40                  45              


<210>  7253
<211>  813
<212>  DNA
<213>  Homosapiens

<400>  7253
aggagcgcgc atgagcggac gctgcctacg ggtggccggg cgggatgtaa ccggctgctg     60

agctggcagt tctgtgtcgc taggcttctg cccggccgcc gccgcacata agctgcgagg    120

aggagcttta cgacttcccg gtcttcgggg ccgggcgcag caagggccag actctgcgct    180

agcaggcgct gcgcgccaac cggccggcac ctgtcgcaga aggtgcaacc gatcgcactg    240

tcgcgcagaa gctcctcaat ggccagcgcc agctgcagcc ccggccgccc actcgcctca    300

tctgagcctg gctggcagcc tgctatcaat tacattgata gtaaatttga ggactaccta    360

aatgcagaat cgcaagtgaa cagatgtcag atgcctggta acagggtgca gtgttgttta    420

tacttcattg ctccttcagg acatggctct gttcacggaa agggcctggg agctgcaaca    480

cctcaacagc aacgagcaca cctgctacct agaacttggt ttctaaaaac catcctcctc    540

taaaaggaaa cagagctctt tgaagaaatg gtaatttcaa agctagagca cagaaagtat    600

aagatgagcc cagaatatct ttttgtacaa gaaagtaagg caatgctcaa agaatgatgg    660

agacatgccc aaaaaaagca gagaagccaa cttgaaaaga ttccaacagg ccaaatatgg    720

gacaatttga acatcagaat aaaatggtga cagtcacaga attataaccc attgaagaaa    780

ggaattcatg acatcatatt aatataaata ata                                 813


<210>  7254
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  7254

Met Ala Ser Ala Ser Cys Ser Pro Gly Arg Pro Leu Ala Ser Ser Glu 
1               5                   10                  15      


Pro Gly Trp Gln Pro Ala Ile Asn Tyr Ile Asp Ser Lys Phe Glu Asp 
            20                  25                  30          


Tyr Leu Asn Ala Glu Ser Gln Val Asn Arg Cys Gln Met Pro Gly Asn 
        35                  40                  45              


Arg Val Gln Cys Cys Leu Tyr Phe Ile Ala Pro Ser Gly His Gly Ser 
    50                  55                  60                  


Val His Gly Lys Gly Leu Gly Ala Ala Thr Pro Gln Gln Gln Arg Ala 
65                  70                  75                  80  


His Leu Leu Pro Arg Thr Trp Phe Leu Lys Thr Ile Leu Leu 
                85                  90                  


<210>  7255
<211>  754
<212>  DNA
<213>  Homosapiens

<400>  7255
aagggccaga ctctgcgcta gcaggcgctg cgcgccaacc ggccggcacc tgtcgcagaa     60

ggtgcaaccg atcgcactgt cgcgcagaag ctcctcaatg gccagcgcca gctgcagccc    120

cggccgccca ctcgcctcat ctgagcctgg ctggcagcct gctatcaatt acattgatag    180

taaatttgag gactacctaa atgcagaatc gcaagtgaac agatgtcaga tgcctggtaa    240

cagggtgcag tgttgtttat acttcattgc tccttcagga catggagaca gatctcatta    300

tgttgcccag ggtgatcctt gatctcctgg cctcaagtga tcctccaacc ttggtctccc    360

aaagtgctgg gattacagat gtgaactacc acacccagtc aacgtgcaga aggttttcag    420

tttgatgtag tctgatgtag tctcatgtat ttatccttgt tgttgttgcc tgagcttttg    480

gtgtgatatc caaaaatatc attgccaaga tcaatatcaa gaaactttcc ccctatgttt    540

cttacagaaa ttttatggtt tcagattttt catctatttt gagtatattt ttgtgtatga    600

tgtaagataa gggtccagtc tccccagtgt tggatatcca attttcataa caccatttat    660

tgaagagatt attctttctc cactgtgttt tcttgatgtc cttgtcaaaa attagttgac    720

ttttatatgc ttgggtttat ttctgggctc tatt                                754


<210>  7256
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  7256

Met Ala Ser Ala Ser Cys Ser Pro Gly Arg Pro Leu Ala Ser Ser Glu 
1               5                   10                  15      


Pro Gly Trp Gln Pro Ala Ile Asn Tyr Ile Asp Ser Lys Phe Glu Asp 
            20                  25                  30          


Tyr Leu Asn Ala Glu Ser Gln Val Asn Arg Cys Gln Met Pro Gly Asn 
        35                  40                  45              


Arg Val Gln Cys Cys Leu Tyr Phe Ile Ala Pro Ser Gly His Gly Asp 
    50                  55                  60                  


Arg Ser His Tyr Val Ala Gln Gly Asp Pro 
65                  70                  


<210>  7257
<211>  668
<212>  DNA
<213>  Homosapiens

<400>  7257
ccagagtatc caggtccttc tcagagaatt aaaaagcctg tacaggtcta catattggta     60

tttttaattg atgataagct ggaataatat taatacacac aaagcacgtg ttgtaacttt    120

cattatgctt ccctagaggt ggaacaatcc aaagttttaa tcagagaagg tggtgttcag    180

ttgctgctta caatagttga taccccagta tttggagatg cagtggataa cagtaattgc    240

tggcagcctg ctatcaatta cattgatagt aaatttgagg actacctaaa tgcagaatcg    300

caagtgaaca gatgtcagat gcctggtaac agggtgcagt gttgtttata cttcattgct    360

ccttcaggac atggagacag atctcattat gttgcccagg gtgatccttg atctcctggc    420

ctcaagtgat cctccaacct tggtctccca aagtgctggg attacagatg tgaactacca    480

cacccagtca acgtgcagaa ggttttcagt ttgatgtagt ctgatgtagt ctcatgtatt    540

tatccttgtt gttgttgcct gagcttttgg tgtgatatcc aaaaatatca ttgccaagat    600

caatatcaag aaactttccc cctatgtttc ttacagaaat tttatggttt cagatttttc    660

atctattt                                                             668


<210>  7258
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  7258

Met Glu Thr Asp Leu Ile Met Leu Pro Arg Val Ile Leu Asp Leu Leu 
1               5                   10                  15      


Ala Ser Ser Asp Pro Pro Thr Leu Val Ser Gln Ser Ala Gly Ile Thr 
            20                  25                  30          


Asp Val Asn Tyr His Thr Gln Ser Thr Cys Arg Arg Phe Ser Val 
        35                  40                  45          


<210>  7259
<211>  2669
<212>  DNA
<213>  Homosapiens

<400>  7259
accctaccag aatacacttt tttttattaa ctgtctggac ctttgctgat tacattgtcc     60

ggaatgtgga gtatcgcatt tgagaagagg attggatcct agccataaca taaatataag    120

ggtaattaca tccatgctga gaaagattta ggaatgatag taagttcatt tgagtgagtg    180

gtttgggcca aacttgatag agaatagtcc aggaagacat ttactataaa cagtagatta    240

aatgttcttg cctggttaat tacatttgaa ctctgttaat gactgaatca ctcaaactgc    300

ttaattgtat tattagatgc acatttaagt tatgtattac atgtctttag tggtgatcag    360

aattttatca gttcctctgt ctttctttat accaagtatg actcataaac ccagtattaa    420

tttgccaaga gattggcata ctatttgtat atatgctttt ctttcaaata atctggattc    480

ccaatgccca caatcattga tcctaaagaa aatgtgagag taggtagata aactcaaaca    540

tccctaccat cacccctggt aggaaatcac tggtgtaatg tatgatatta acatctgcac    600

caattactct tataggtgga acaatccaaa gttttaatca gagaaggtgg tgttcagttg    660

ctgcttacaa tagttgatac cccagtattt ggagatgcag tggataacag taattggtaa    720

aaaggatttg tcctcacaac tttccagtgt atttggggta ctggggtggt taaactttct    780

cttcttaaca ttttaaaact cttcttagca aaggtcacca aacttcaagt aacatgacag    840

gtttgtatac caactttgcc acttatttga caaagtttaa cttcaaagtt aaacaaagaa    900

gtttaacttc tttgaaccca tttacttttt gataaaatgg agataatacc tatcataaaa    960

ttgttttgaa gacatattcc aaaataacgt agctagatag aagaattctc attattggaa   1020

gaaatttaaa atgctttgct ttaattttat ccatttgtat aaattctatc acaatcctaa   1080

tttaaacctg atatttagac cttcagtttt tccataagtc ctaagtgaag aaaacaacta   1140

tgaaatttta gtctgaagta attatcttag tattttataa ataactttaa ttttgtttga   1200

attcacattg tttttgaggt atttttctgt caactcttaa aactcctaag ttcatcatga   1260

agtttttata ttatttaagt aatctctcat ttgaaatttg aaactgaata taatcgtttt   1320

catattatga agtgtgttat taatacactt actagtgcca atagtatgct aataatttag   1380

ctgtgtttca acaataaata ttttctttca tttggaaagt tttgaaataa tgaataaaga   1440

tttattcaac acaatttata tttttgaatc tttatataga ataacttgac atatcttcca   1500

ttggttaatt cattttgcct atttgaaaat attgattatt gtcctttaac agtcatcagt   1560

taattcatat gtagaattgc aacttaattg ttttgtttat ttgcattcta tagctggcag   1620

cctgctatca attacattga tagtaaattt gaggactacc taaatgcaga atcgcaagtg   1680

aacagatgtc agatgcctgg taacagggtg cagtgttgtt tatacttcat tgctccttca   1740

ggacatggct ctgttcacgg aaagggcctg ggagctgcaa cacctcaaca gcaacgagca   1800

cacctgctac ctagaacttg gtttctaaaa accatcctcc tctaaaagga aacagagctc   1860

tttgaagaaa tgagacagat ctcattatgt tgcccagggt gatccttgat ctcctggcct   1920

caagtgatcc tccaaccttg gtctcccaaa gtgctgggat tacagatgtg aactaccaca   1980

cccagtcaac gtgcagaagg ttttcagttt gatgtagtct gatgtagtct catgtattta   2040

tccttgttgt tgttgcctga gcttttggtg tgatatccaa aaatatcatt gccaagatca   2100

atatcaagaa actttccccc tatgtttctt acagaaattt tatggtttca gatttttcat   2160

ctattttgag tatatttttg tgtatgatgt aagataaggg tccagtctcc ccagtgttgg   2220

atatccaatt ttcataacac catttattga agagattatt ctttctccac tgtgttttct   2280

tgatgtcctt gtcaaaaatt agttgacttt tatatgcttg ggtttatttc tgggctctat   2340

tctgtttcat tgctttacat ctctgttttc atgccagtgc cacagtgttt tgattactat   2400

agctttgtaa tataatttga aatcagaatg tgtaatacct ataactttgt tttttgctct   2460

aaagatttat ttatttattt atttattttt gccatttcag gtcttttgtg gtttcatatg   2520

aatttcagaa ttgtttttcc tatttctgtg aaaaatgcca ttgacatttt gatagggatt   2580

gtgttgaatc tatatattgc tttggatagt atggatgttt taacactatt aattctccca   2640

atccatgaac atgaaatatc tttccattc                                     2669


<210>  7260
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  7260

Met Pro Gly Asn Arg Val Gln Cys Cys Leu Tyr Phe Ile Ala Pro Ser 
1               5                   10                  15      


Gly His Gly Ser Val His Gly Lys Gly Leu Gly Ala Ala Thr Pro Gln 
            20                  25                  30          


Gln Gln Arg Ala His Leu Leu Pro Arg Thr Trp Phe Leu Lys Thr Ile 
        35                  40                  45              


Leu Leu 
    50  


<210>  7261
<211>  334
<212>  DNA
<213>  Homosapiens

<400>  7261
cccagggagg tggctttaat cttggttctc cagtgtcagg aagagatcct tcagtcatgg     60

gagaaccttt cttggccgag ttcgtagtca gagggagatg tgactacaga agaatggttg    120

gacacgtgca acactgtggg ctttacagag gaaggaaggg gacatgagcc aaggaactct    180

ggcagcctct agaagctaaa aaaggtaatc aggaagtctc ctaggataag gttattatat    240

tcaagtcctg ccaaaaaatg taagaaaaga agctcctatt tgagtggacc aaaaagaaca    300

attatacctc ctaaaaataa aatgaaccta agct                                334


<210>  7262
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  7262

Met Gly Glu Pro Phe Leu Ala Glu Phe Val Val Arg Gly Arg Cys Asp 
1               5                   10                  15      


Tyr Arg Arg Met Val Gly His Val Gln His Cys Gly Leu Tyr Arg Gly 
            20                  25                  30          


Arg Lys Gly Thr 
        35      


<210>  7263
<211>  1351
<212>  DNA
<213>  Homosapiens

<400>  7263
ggggtaagga atcaagcccc caagatggcg gcagcggcgg aggagcggat ggcagaggaa     60

ggaggcggcg gccaaggcga cggcggttcc tctttggcct ccggctctac ccagcgacag    120

cctccaccgc ccgcgccaca gcacccgcag ccggggtccc aggcgctccc agcccccgcg    180

ctggctccgg accagctgcc tcaaaacaac acgcttgtgg cgctgcccat cgtagccatc    240

gagaacatcc tcagctttat gtcctacgac gaaattagcc agctccgcct ggtttgtaaa    300

agaatggact tggtctgcca gagaatgttg aatcagggat ttctgaaagt ggagaggtac    360

cataatctat gtcagaaaca agttaaagca caactcccaa ggagagagtc agaaaggaga    420

aaccattcat tagctcgtca tgcagacatt cttgctgctg ttgaaacaag gctgtcacta    480

ttaaatatga ctttcatgaa atatgtggat tccaatctct gttgcttcat cccaggaaag    540

gtgattgatg agatttatcg tgtgttgaga tatgtcaatt ctaccagagc ccctcaacga    600

gctcatgaag tacttcaaga attaagggat atatcctcta tggcaatgga gtactttgat    660

gaaaagattg ttccaatttt aaagaggaaa ttaccaggat cagatgtttc tggaagactc    720

atgggctctc ctccagttcc aggaccgtct gcagccctaa caacaatgca gctcttctcc    780

aagcaaaatc cttcaagaca agaggttacc aaactccagc agcaggttaa aacaaatggt    840

gctggcgtga ctgttctcag gcgtgaaatt tctgagcttc gcaccaaagt gcaagaacag    900

caaaaacagc ttcaagacca ggaccagaaa ctgctagagc agacccagat cataggtgaa    960

caaaatgcac ggttggcaga gctagaacgc aaactacgag aagtaatgga aagtgctgta   1020

ggaaattcct cagggtccgg gcagaatgag gagtctcctc ggaaacgaaa aaaggccacg   1080

gaagccatag actctcttag gaaatctaaa cgtcttcgga atagaaagta aattggaatg   1140

tggttctagt tccagaggaa gacacagctt agtagcttaa gcagttatgc atatcaggat   1200

actgtgagca acatggtgtc ccttaagctt ctaggctttc agaacacaac ttaaacttga   1260

actcttatgg ttgggacatt cttttcctgc ttctcctgat tgaactgatg cacagaatct   1320

ttttactttg caatagattt gtactaacca g                                  1351


<210>  7264
<211>  368
<212>  PRT
<213>  Homosapiens

<400>  7264

Met Ala Ala Ala Ala Glu Glu Arg Met Ala Glu Glu Gly Gly Gly Gly 
1               5                   10                  15      


Gln Gly Asp Gly Gly Ser Ser Leu Ala Ser Gly Ser Thr Gln Arg Gln 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro Gln His Pro Gln Pro Gly Ser Gln Ala Leu 
        35                  40                  45              


Pro Ala Pro Ala Leu Ala Pro Asp Gln Leu Pro Gln Asn Asn Thr Leu 
    50                  55                  60                  


Val Ala Leu Pro Ile Val Ala Ile Glu Asn Ile Leu Ser Phe Met Ser 
65                  70                  75                  80  


Tyr Asp Glu Ile Ser Gln Leu Arg Leu Val Cys Lys Arg Met Asp Leu 
                85                  90                  95      


Val Cys Gln Arg Met Leu Asn Gln Gly Phe Leu Lys Val Glu Arg Tyr 
            100                 105                 110         


His Asn Leu Cys Gln Lys Gln Val Lys Ala Gln Leu Pro Arg Arg Glu 
        115                 120                 125             


Ser Glu Arg Arg Asn His Ser Leu Ala Arg His Ala Asp Ile Leu Ala 
    130                 135                 140                 


Ala Val Glu Thr Arg Leu Ser Leu Leu Asn Met Thr Phe Met Lys Tyr 
145                 150                 155                 160 


Val Asp Ser Asn Leu Cys Cys Phe Ile Pro Gly Lys Val Ile Asp Glu 
                165                 170                 175     


Ile Tyr Arg Val Leu Arg Tyr Val Asn Ser Thr Arg Ala Pro Gln Arg 
            180                 185                 190         


Ala His Glu Val Leu Gln Glu Leu Arg Asp Ile Ser Ser Met Ala Met 
        195                 200                 205             


Glu Tyr Phe Asp Glu Lys Ile Val Pro Ile Leu Lys Arg Lys Leu Pro 
    210                 215                 220                 


Gly Ser Asp Val Ser Gly Arg Leu Met Gly Ser Pro Pro Val Pro Gly 
225                 230                 235                 240 


Pro Ser Ala Ala Leu Thr Thr Met Gln Leu Phe Ser Lys Gln Asn Pro 
                245                 250                 255     


Ser Arg Gln Glu Val Thr Lys Leu Gln Gln Gln Val Lys Thr Asn Gly 
            260                 265                 270         


Ala Gly Val Thr Val Leu Arg Arg Glu Ile Ser Glu Leu Arg Thr Lys 
        275                 280                 285             


Val Gln Glu Gln Gln Lys Gln Leu Gln Asp Gln Asp Gln Lys Leu Leu 
    290                 295                 300                 


Glu Gln Thr Gln Ile Ile Gly Glu Gln Asn Ala Arg Leu Ala Glu Leu 
305                 310                 315                 320 


Glu Arg Lys Leu Arg Glu Val Met Glu Ser Ala Val Gly Asn Ser Ser 
                325                 330                 335     


Gly Ser Gly Gln Asn Glu Glu Ser Pro Arg Lys Arg Lys Lys Ala Thr 
            340                 345                 350         


Glu Ala Ile Asp Ser Leu Arg Lys Ser Lys Arg Leu Arg Asn Arg Lys 
        355                 360                 365             


<210>  7265
<211>  2922
<212>  DNA
<213>  Homosapiens

<400>  7265
ggggtaagga atcaagcccc caagatggcg gcagcggcgg aggagcggat ggcagaggaa     60

ggaggcggcg gccaaggcga cggcggttcc tctttggcct ccggctctac ccagcgacag    120

cctccaccgc ccgcgccaca gcacccgcag ccggggtccc aggcgctccc agcccccgcg    180

ctggctccgg accagctgcc tcaaaacaac acgcttgtgg cgctgcccat cgtagccatc    240

gagaacatcc tcagctttat gtcctacgac gaaattagcc agctccgcct ggtttgtaaa    300

agaatggact tggtctgcca gagaatgttg aatcagggat ttctgaaagt ggagaggtac    360

cataatctat gtcagaaaca agttaaagca caactcccaa ggagagagtc agaaaggaga    420

aaccattcat tagctcgtca tgcagacatt cttgctgctg ttgaaacaag gctgtcacta    480

ttaaatatga ctttcatgaa atatgtggat tccaatctct gttgcttcat cccaggaaag    540

gtgattgatg agatttatcg tgtgttgaga tatgtcaatt ctaccagagc ccctcaacga    600

gctcatgaag tacttcaaga attaagggat atatcctcta tggcaatgga gtactttgat    660

gaaaagattg ttccaatttt aaagaggaaa ttaccaggat cagatgtttc tggaagactc    720

atgggctctc ctccagttcc aggaccgtct gcagccctaa caacaatgca gctcttctcc    780

aagcaaaatc cttcaagaca agaggttacc aaactccagc agcaggttaa aacaaatggt    840

gctggcgtga ctgttctcag gcgtgaaatt tctgagcttc gcaccaaagt gcaagaacag    900

caaaaacagc ttcaagacca ggaccagaaa ctgctagagc agacccagat cataggtgaa    960

caaaatgcac ggttggcaga gctagaacgc aaactacgag aagtaatgga aagtgctgta   1020

ggaaattcct cagggtccgg gcagaatgag gagtctcctc ggaaacgaaa aaaggccacg   1080

gaagccatag actctcttag gaaatctaaa cgtcttcgga atagaaagta aattggaatg   1140

tggttctagt tccagaggaa gacacagctt agtagcttaa gcagttatgc atatcaggat   1200

actgtgagca acatggtgtc ccttaagctt ctaggctttc agaacacaac ttaaacttga   1260

actcttatgg ttgggacatt cttttcctgc ttctcctgat tgaactgatg cacagaatct   1320

ttttactttg caatagattt gtactaacca gacctgttct atcatgtttt gaggagttaa   1380

cttttttctg tgcagataat gttgaaagta agttaatttg tttctgcata tatgcacata   1440

catacgtaag gatcttaaac ccagtcttga cagactagaa gttaagttta atacagaaaa   1500

tgtcctgttc acttgaaaga aaagacctac tttttaaatg gacactatct tggttctttt   1560

ttttttaagt catctttttg ttataagtga cctttgtctg gaatgtctga aaagtagtta   1620

atgctttttg gtattgaagt aatgggtaac taaaatggac ttccatagta ttgactgtag   1680

aaggagcctc tacaatattg actatatatt tttataaact actggcaagg aacttaccca   1740

gctgttatac atgttttcag ttctctttgg gggccatgtc ctacatttgc atggatggat   1800

gcatgcattg cctagtcaac tcacttaaaa agctcttgca ctggtattga tcttgaacct   1860

ctatacttct ccacttttta gagcggcgtc ttagtttatt taaacgctta acatcttcca   1920

ccgcaacagc ttgcctctag agggggaatt gttcatccat ttgtcctcca gttttatagg   1980

aacaagagac tattaaagcc cattgcttta tctgctctct gtagggttca ggtacactgg   2040

ctaaggcaga accccaaatt tcaaggctct ttctatcaat attggacctc tgggagctaa   2100

tactcctctt tgctcaccac catgtgatca ttgatcagat gtggtgagtg agtaggggac   2160

tcgacttgcg ggatgcagtt ttgccattgc agcaaagttc attgaggaaa attgtaccat   2220

gaaaaagcat tttgattatt tcatttctgg aggatgacct tgagggaagc tttttaatat   2280

tagtttcaag ctttccttac cctacaactt taaacaaaag ctttaatttt gtttgcactc   2340

ctattttgag cttgtaactg gaaaagcatg tcttgcactg ttcaacctcc tgagtggtcg   2400

ctttaacaac ctccaaattg tgtacagtgg ttattttccc cagttgtata gttttgagac   2460

attcaattat cactgtctta gttgtatttt aatttactaa attatgtagc tatttgactg   2520

ttaagttctt ttaaacaact gtttccttgg gcttcagtta tttaaagtaa atttaggtgt   2580

aatatagaaa actgtccctt tccaggtggg agcttaacac ctgtataaaa cctaaggttt   2640

tggtaagtac cttagttgaa taaaagcaca aggttatcac cttttttatc cgtccaccgt   2700

gacatggtta tgcatccttt agattaacct caccaaatga agctttttct atccattttt   2760

aatattgtcc ttacataata ttgtccttag attttgatca attctatgtc tgactttgaa   2820

attccattta caatgtagta tgttttcaat gaaaaaccat aaagtaacat ccaagtgttt   2880

catggtttgt tgggaaggta attttaaaat aaaacaattt cc                      2922


<210>  7266
<211>  368
<212>  PRT
<213>  Homosapiens

<400>  7266

Met Ala Ala Ala Ala Glu Glu Arg Met Ala Glu Glu Gly Gly Gly Gly 
1               5                   10                  15      


Gln Gly Asp Gly Gly Ser Ser Leu Ala Ser Gly Ser Thr Gln Arg Gln 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro Gln His Pro Gln Pro Gly Ser Gln Ala Leu 
        35                  40                  45              


Pro Ala Pro Ala Leu Ala Pro Asp Gln Leu Pro Gln Asn Asn Thr Leu 
    50                  55                  60                  


Val Ala Leu Pro Ile Val Ala Ile Glu Asn Ile Leu Ser Phe Met Ser 
65                  70                  75                  80  


Tyr Asp Glu Ile Ser Gln Leu Arg Leu Val Cys Lys Arg Met Asp Leu 
                85                  90                  95      


Val Cys Gln Arg Met Leu Asn Gln Gly Phe Leu Lys Val Glu Arg Tyr 
            100                 105                 110         


His Asn Leu Cys Gln Lys Gln Val Lys Ala Gln Leu Pro Arg Arg Glu 
        115                 120                 125             


Ser Glu Arg Arg Asn His Ser Leu Ala Arg His Ala Asp Ile Leu Ala 
    130                 135                 140                 


Ala Val Glu Thr Arg Leu Ser Leu Leu Asn Met Thr Phe Met Lys Tyr 
145                 150                 155                 160 


Val Asp Ser Asn Leu Cys Cys Phe Ile Pro Gly Lys Val Ile Asp Glu 
                165                 170                 175     


Ile Tyr Arg Val Leu Arg Tyr Val Asn Ser Thr Arg Ala Pro Gln Arg 
            180                 185                 190         


Ala His Glu Val Leu Gln Glu Leu Arg Asp Ile Ser Ser Met Ala Met 
        195                 200                 205             


Glu Tyr Phe Asp Glu Lys Ile Val Pro Ile Leu Lys Arg Lys Leu Pro 
    210                 215                 220                 


Gly Ser Asp Val Ser Gly Arg Leu Met Gly Ser Pro Pro Val Pro Gly 
225                 230                 235                 240 


Pro Ser Ala Ala Leu Thr Thr Met Gln Leu Phe Ser Lys Gln Asn Pro 
                245                 250                 255     


Ser Arg Gln Glu Val Thr Lys Leu Gln Gln Gln Val Lys Thr Asn Gly 
            260                 265                 270         


Ala Gly Val Thr Val Leu Arg Arg Glu Ile Ser Glu Leu Arg Thr Lys 
        275                 280                 285             


Val Gln Glu Gln Gln Lys Gln Leu Gln Asp Gln Asp Gln Lys Leu Leu 
    290                 295                 300                 


Glu Gln Thr Gln Ile Ile Gly Glu Gln Asn Ala Arg Leu Ala Glu Leu 
305                 310                 315                 320 


Glu Arg Lys Leu Arg Glu Val Met Glu Ser Ala Val Gly Asn Ser Ser 
                325                 330                 335     


Gly Ser Gly Gln Asn Glu Glu Ser Pro Arg Lys Arg Lys Lys Ala Thr 
            340                 345                 350         


Glu Ala Ile Asp Ser Leu Arg Lys Ser Lys Arg Leu Arg Asn Arg Lys 
        355                 360                 365             


<210>  7267
<211>  5432
<212>  DNA
<213>  Homosapiens

<400>  7267
ggggtaagga atcaagcccc caagatggcg gcagcggcgg aggagcggat ggcagaggaa     60

ggaggcggcg gccaaggcga cggcggttcc tctttggcct ccggctctac ccagcgacag    120

cctccaccgc ccgcgccaca gcacccgcag ccggggtccc aggcgctccc agcccccgcg    180

ctggctccgg accagctgcc tcaaaacaac acgcttgtgg cgctgcccat cgtagccatc    240

gagaacatcc tcagctttat gtcctacgac gaaattagcc agctccgcct ggtttgtaaa    300

agaatggact tggtctgcca gagaatgttg aatcagggat ttctgaaagt ggagaggtac    360

cataatctat gtcagaaaca agttaaagca caactcccaa ggagagagtc agaaaggaga    420

aaccattcat tagctcgtca tgcagacatt cttgctgctg ttgaaacaag gctgtcacta    480

ttaaatatga ctttcatgaa atatgtggat tccaatctct gttgcttcat cccaggaaag    540

gtgattgatg agatttatcg tgtgttgaga tatgtcaatt ctaccagagc ccctcaacga    600

gctcatgaag tacttcaaga attaagggat atatcctcta tggcaatgga gtactttgat    660

gaaaagattg ttccaatttt aaagaggaaa ttaccaggat cagatgtttc tggaagactc    720

atgggctctc ctccagttcc aggaccgtct gcagccctaa caacaatgca gctcttctcc    780

aagcaaaatc cttcaagaca agaggttacc aaactccagc agcaggttaa aacaaatggt    840

gctggcgtga ctgttctcag gcgtgaaatt tctgagcttc gcaccaaagt gcaagaacag    900

caaaaacagc ttcaagacca ggaccagaaa ctgctagagc agacccagat cataggtgaa    960

caaaatgcac ggttggcaga gctagaacgc aaactacgag aagtaatgga aagtgctgta   1020

ggaaattcct cagggtccgg gcagaatgag gagtctcctc ggaaacgaaa aaaggccacg   1080

gaagccatag actctcttag gaaatctaaa cgtcttcgga atagaaagta aattggaatg   1140

tggttctagt tccagaggaa gacacagctt agtagcttaa gcagttatgc atatcaggat   1200

actgtgagca acatggtgtc ccttaagctt ctaggctttc agaacacaac ttaaacttga   1260

actcttatgg ttgggacatt cttttcctgc ttctcctgat tgaactgatg cacagaatct   1320

ttttactttg caatagattt gtactaacca gacctgttct atcatgtttt gaggagttaa   1380

cttttttctg tgcagataat gttgaaagta agttaatttg tttctgcata tatgcacata   1440

catacgtaag gatcttaaac ccagtcttga cagactagaa gttaagttta atacagaaaa   1500

tgtcctgttc acttgaaaga aaagacctac tttttaaatg gacactatct tggttctttt   1560

ttttttaagt catctttttg ttataagtga cctttgtctg gaatgtctga aaagtagtta   1620

atgctttttg gtattgaagt aatgggtaac taaaatggac ttccatagta ttgactgtag   1680

aaggagcctc tacaatattg actatatatt tttataaact actggcaagg aacttaccca   1740

gctgttatac atgttttcag ttctctttgg gggccatgtc ctacatttgc atggatggat   1800

gcatgcattg cctagtcaac tcacttaaaa agctcttgca ctggtattga tcttgaacct   1860

ctatacttct ccacttttta gagcggcgtc ttagtttatt taaacgctta acatcttcca   1920

ccgcaacagc ttgcctctag agggggaatt gttcatccat ttgtcctcca gttttatagg   1980

aacaagagac tattaaagcc cattgcttta tctgctctct gtagggttca ggtacactgg   2040

ctaaggcaga accccaaatt tcaaggctct ttctatcaat attggacctc tgggagctaa   2100

tactcctctt tgctcaccac catgtgatca ttgatcagat gtggtgagtg agtaggggac   2160

tcgacttgcg ggatgcagtt ttgccattgc agcaaagttc attgaggaaa attgtaccat   2220

gaaaaagcat tttgattatt tcatttctgg aggatgacct tgagggaagc tttttaatat   2280

tagtttcaag ctttccttac cctacaactt taaacaaaag ctttaatttt gtttgcactc   2340

ctattttgag cttgtaactg gaaaagcatg tcttgcactg ttcaacctcc tgagtggtcg   2400

ctttaacaac ctccaaattg tgtacagtgg ttattttccc cagttgtata gttttgagac   2460

attcaattat cactgtctta gttgtatttt aatttactaa attatgtagc tatttgactg   2520

ttaagttctt ttaaacaact gtttccttgg gcttcagtta tttaaagtaa atttaggtgt   2580

aatatagaaa actgtccctt tccaggtggg agcttaacac ctgtataaaa cctaaggttt   2640

tggtaagtac cttagttgaa taaaagcaca aggttatcac cttttttatc cgtccaccgt   2700

gacatggtta tgcatccttt agattaacct caccaaatga agctttttct atccattttt   2760

aatattgtcc ttacataata ttgtccttag attttgatca attctatgtc tgactttgaa   2820

attccattta caatgtagta tgttttcaat gaaaaaccat aaagtaacat ccaagtgttt   2880

catggtttgt tgggaaggta attttaaaat aaaacaattt ccaaaaaaca tttgtcagcc   2940

aaggtcatcc ataaaagtcc ccgtctggaa ctcgttttct cagcacttct catttttata   3000

atcatagtat ttagccatat tagcatatct ttagaggagg cctggtggaa tacccggggc   3060

ctctactagt ctgcttttcc ggtcatagga agactttttt ttttacgtat caaagcatgt   3120

gtttacagat ttacagagtg tgatccgtat gcatcaaagg gatacagccc cagactgttt   3180

ctttaatggt cattcatgaa ctattaaaaa tttcctgaat ttctttttaa actacatcta   3240

gatagcctaa acatctatgt agtcttccat tagttaacat gtgtataggg ctttcataat   3300

aagtagtcac actgttacaa ggtaaatttt ctattacaaa atccaaattt ctattgcata   3360

cacttataat catctattca taaagctaat tcattgtact tgttaatgca tgaatgttcc   3420

atgcagtagg agaataaagc actacagttc ggttgttcaa atcttaaatc ttaggctatt   3480

tagctaaaac atgttaggat attgccttca ccacttgtta ggacagttat ttgatagcca   3540

ttatgcttac ctatggatag cataatggta tttaaggttc aacaaaccgc agattattat   3600

gatcagctag aactgacata tgttacaaga aaactgtaaa ttaacctcct gagagaacca   3660

ttctgccctg cattttaagt caggtattta aatactgcgt gttgttaata ttgcgttgtc   3720

ttagtgcaac atttcttaaa gtattcccgt tatcttcctt ggctgttttt cagaggagac   3780

gtctccatgt taatgggtcc ttcccacata gaaatgtatt ctggtacagc gctgcacaca   3840

tggatagcaa tgtgaaaagg catgcctaag agacagaaac ggctgacctt accccacccc   3900

agccggatcc tctgcttatc tcccacatgc acttggctta actggttttc acagattctg   3960

aggttataga acctgttgtt tttcaaactc ctgtacagag cctggaaata atggagcaaa   4020

cgcaaatgta ttgagagtca ttatacttta aaatagtttt aaagactatt ggggtaccat   4080

caggtcaaaa gccactgatt tgggaagcaa tttttttgca aaacactttt tttggagtac   4140

tgaactttac aggggcttgc cttaatctct atttagtagt ttcaagatat atgcgcaatt   4200

attctacgtg ttaaaaatgt taaaatattc tatgtagccc caaaggtggg taaaacagta   4260

taagtaatgc ctaaattaat aagctaaaag gtgtcactac agctggattt ttgagagaaa   4320

atggacataa aactaggcta tgtgtaataa aaataatggc accttaagat tgcactattt   4380

tatgcattat tttatatgcc atttcatagc ctgcacttta atctccaaag aaacgatgta   4440

tgatgtccca cttgttcctt attcttaata aactttttcc tgagacaggg cacttaattc   4500

tattttacta tactgaatta gtttcttgga ggtagattca tttcttgagt tctctgtttc   4560

cttagccata atattttcta ggatccggga actccctata ttgtctattt ccaacattat   4620

ataattttaa tttaatgtaa tgtaaatctc atacttggtg atcagcacat tcttatatcc   4680

tgctctagca atgagtaccc atttgttaca cttaccaaac tctctaaaaa catatactgt   4740

gagtaagatt tgaagccagg aataaaaggc agtctgaaag aaaacgtcct atacgatgca   4800

gttgtttgga aatggctgat ttctgatatg aaacccaact tgatacactg tttggttctt   4860

tgacttggga tctatctgaa ttgctttcac tagtacacaa aaggttaagt taaaactact   4920

ttaaacttgt atagcctgcc atctgaggtg aattattttc aaaaaatact aaatctatga   4980

actgagacta gcaattagtt ggctgctccc taccatgatt ttacttttaa tagcaataca   5040

gttatattgg tgataaatat gacaggctta agtactgctg tccttttgca tcttcctaag   5100

catcttggtt aaatttctga agtttaaaaa ttagatccag atttcttctg ttgtgtctga   5160

agagaaccat gacatttaga agtatattgg taatctatta ggtccattgg caaagtatat   5220

tggtccatat tcaaacctat tccaaaaggt tagaagtgtt taagattcct ttattgtggt   5280

accatgtctg tttacctatg cttatgagca acaataaatt actagtttac cttctggaat   5340

tttaattgtt ataaccgaat caattattgg aaagtgaaaa acacctcccg gtcacacaac   5400

agggtacgta aataaatgtg ttgttaccag tg                                 5432


<210>  7268
<211>  368
<212>  PRT
<213>  Homosapiens

<400>  7268

Met Ala Ala Ala Ala Glu Glu Arg Met Ala Glu Glu Gly Gly Gly Gly 
1               5                   10                  15      


Gln Gly Asp Gly Gly Ser Ser Leu Ala Ser Gly Ser Thr Gln Arg Gln 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro Gln His Pro Gln Pro Gly Ser Gln Ala Leu 
        35                  40                  45              


Pro Ala Pro Ala Leu Ala Pro Asp Gln Leu Pro Gln Asn Asn Thr Leu 
    50                  55                  60                  


Val Ala Leu Pro Ile Val Ala Ile Glu Asn Ile Leu Ser Phe Met Ser 
65                  70                  75                  80  


Tyr Asp Glu Ile Ser Gln Leu Arg Leu Val Cys Lys Arg Met Asp Leu 
                85                  90                  95      


Val Cys Gln Arg Met Leu Asn Gln Gly Phe Leu Lys Val Glu Arg Tyr 
            100                 105                 110         


His Asn Leu Cys Gln Lys Gln Val Lys Ala Gln Leu Pro Arg Arg Glu 
        115                 120                 125             


Ser Glu Arg Arg Asn His Ser Leu Ala Arg His Ala Asp Ile Leu Ala 
    130                 135                 140                 


Ala Val Glu Thr Arg Leu Ser Leu Leu Asn Met Thr Phe Met Lys Tyr 
145                 150                 155                 160 


Val Asp Ser Asn Leu Cys Cys Phe Ile Pro Gly Lys Val Ile Asp Glu 
                165                 170                 175     


Ile Tyr Arg Val Leu Arg Tyr Val Asn Ser Thr Arg Ala Pro Gln Arg 
            180                 185                 190         


Ala His Glu Val Leu Gln Glu Leu Arg Asp Ile Ser Ser Met Ala Met 
        195                 200                 205             


Glu Tyr Phe Asp Glu Lys Ile Val Pro Ile Leu Lys Arg Lys Leu Pro 
    210                 215                 220                 


Gly Ser Asp Val Ser Gly Arg Leu Met Gly Ser Pro Pro Val Pro Gly 
225                 230                 235                 240 


Pro Ser Ala Ala Leu Thr Thr Met Gln Leu Phe Ser Lys Gln Asn Pro 
                245                 250                 255     


Ser Arg Gln Glu Val Thr Lys Leu Gln Gln Gln Val Lys Thr Asn Gly 
            260                 265                 270         


Ala Gly Val Thr Val Leu Arg Arg Glu Ile Ser Glu Leu Arg Thr Lys 
        275                 280                 285             


Val Gln Glu Gln Gln Lys Gln Leu Gln Asp Gln Asp Gln Lys Leu Leu 
    290                 295                 300                 


Glu Gln Thr Gln Ile Ile Gly Glu Gln Asn Ala Arg Leu Ala Glu Leu 
305                 310                 315                 320 


Glu Arg Lys Leu Arg Glu Val Met Glu Ser Ala Val Gly Asn Ser Ser 
                325                 330                 335     


Gly Ser Gly Gln Asn Glu Glu Ser Pro Arg Lys Arg Lys Lys Ala Thr 
            340                 345                 350         


Glu Ala Ile Asp Ser Leu Arg Lys Ser Lys Arg Leu Arg Asn Arg Lys 
        355                 360                 365             


<210>  7269
<211>  1874
<212>  DNA
<213>  Homosapiens

<400>  7269
cggcggccaa ggcgacggcg gttcctcttt ggcctccggc tctacccagc gacagcctcc     60

accgcccgcg ccacagcacc cgcagccggg gtcccaggcg ctcccagccc ccgcgctggc    120

tccggaccag ctgcctcaaa acaacacgct tgtggcgctg cccatcgtag ccatcgagaa    180

catcctcagc tttatgtcct acgacgaaat tagccagctc cgcctggttt gtaaaagaat    240

ggacttggtc tgccagagaa tgttgaatca gggatttctg aaagtggaga ggtaccataa    300

tctatgtcag aaacaagtta aagcacaact cccaaggaga gagtcagaaa ggagaaacca    360

ttcattagct cgtcatgcag acattcttgc tgctgttgaa acaaggctgt cactattaaa    420

tatgactttc atgaaatatg tggattccaa tctctgttgc ttcatcccag gaaaggtaaa    480

atagaattgc ttgcctagaa cagctggact gccctacata aacttattat acagttatga    540

atttctgatt ttagaaatgt tagaattgtt tctacttctc tgagtttcta ctaatgaatt    600

tgtttgcttt ctgtacagtt ataaatatgt atcatttgta tgatctttat atttaaaatt    660

ctaattatga aatagtcgaa accctaatat tctttagaga agttttttaa gagttcatac    720

tcaagaataa aatttgaggt tttactggtg gttatgatgc cagagataca gcaatgaaca    780

acatacatat tgtccctgcc ttcaagacta ttataatttt ggggaggtag aaaaggaggg    840

acaagctggt ttttgttttg tttgagaaat gtttcataac gacaacttta taaactttct    900

gatttgacaa gaataaacaa ttgctattta ccaatattcc cagaactaaa taacagtcct    960

ttttaacaca gaaataacta tattgtggca tatttaccat tactaagtta ataaaaactc   1020

caacattcaa catactactt ataccttcag tagtacccta ctccttgaat taagtgtaaa   1080

ttgacatatg tctgtatctt tttatatgga agtggtagag atataattaa aggtcatttt   1140

gctacttggt tgatgctggc aaaagtttcc cttaacatgg ttggaaataa ttaatatcta   1200

gtaaaatctg aatgttcgct ttttgttatt tccaaagata atttacattg gcaatattta   1260

atacgtactt tgtccatttt tagttttctt tgacatttat ttttgggggg aatcccattt   1320

cttatgattg tatttgaaat attttggtat atctcacttt ctttgcatta tatacatttt   1380

ctttaaaaga tcttgttgca taccaacaca ttacctgcta atgctttttg tagggtgcta   1440

taagaggatg accagttaga aacttcagag tgattcttat gccagatttt tctgaatctg   1500

acttaaaggc cttaactttt aagtgttcct gagttctttg aacttagctt gtttcatata   1560

gcatcatagt ttttattgaa tatctcattg ttagaaacat gaatatctaa gaaacatctc   1620

acagttatca taacttcaaa gagattcagt cagttgttaa gtaacagagt tgaatagttt   1680

gtgacagagt tcatgtggcc tacaaagatt aaaatattta tgatccaggc cggctgtagt   1740

ggctcgcacc tctaatccca gatacttgca aggctgaggc agaagaatcg cttgaacccg   1800

ggaggcggag gttgcactga gccaagatca caccactgca ctccagcctg ggcaacagag   1860

caagactctg tctc                                                     1874


<210>  7270
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  7270

Met Ser Tyr Asp Glu Ile Ser Gln Leu Arg Leu Val Cys Lys Arg Met 
1               5                   10                  15      


Asp Leu Val Cys Gln Arg Met Leu Asn Gln Gly Phe Leu Lys Val Glu 
            20                  25                  30          


Arg Tyr His Asn Leu Cys Gln Lys Gln Val Lys Ala Gln Leu Pro Arg 
        35                  40                  45              


Arg Glu Ser Glu Arg Arg Asn His Ser Leu Ala Arg His Ala Asp Ile 
    50                  55                  60                  


Leu Ala Ala Val Glu Thr Arg Leu Ser Leu Leu Asn Met Thr Phe Met 
65                  70                  75                  80  


Lys Tyr Val Asp Ser Asn Leu Cys Cys Phe Ile Pro Gly Lys Val Lys 
                85                  90                  95      


<210>  7271
<211>  468
<212>  DNA
<213>  Homosapiens

<400>  7271
gctgggatta caggcatgag ccaccgtgcc cggccccact gattttttct tgtatttttc     60

tcccaccatc tcttcaggct attgatttta ttaatgagtg cataagtaca ggtaagaaat    120

tataatctct tgggggcagt tcgttcttcc agttctcaca aagtaaagag gttcagtcag    180

taactctgtc cactgtgtcg tcatcaagag aaaatataca taccttcctt gagcacatgc    240

ctggccccaa atagaatttt ttttaaagat taaagtattc ttttggaaga ggtgggaagt    300

tgtatccata tttaggtgag ggaaattaag atgagttcac tgaaaacaca aacaggacaa    360

gagaagagcc agaatggttg tgattcgttc attattcatt ttttaaatga ttttttcgtc    420

catcattaac tttttgccac atttgcttta tctgtttcac ttttgtgc                 468


<210>  7272
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  7272

Met Ser Ser Leu Lys Thr Gln Thr Gly Gln Glu Lys Ser Gln Asn Gly 
1               5                   10                  15      


Cys Asp Ser Phe Ile Ile His Phe Leu Asn Asp Phe Phe Val His His 
            20                  25                  30          


<210>  7273
<211>  743
<212>  DNA
<213>  Homosapiens

<400>  7273
atgaagctga taattggact caactcagga ggaagttttc aggtgctgac aagtaaatgt     60

atccctgcag ttcagaacgc agttgctatc acaggcatgt gtgaactggc acaccagtcc    120

aaaaggctga ggcggcggcg ggcgcgcgag gctgttgtgc tcccggctct cctgtttccc    180

ctcctgagcg ggtggaggag gcccaagcga tgctgggcgc gctccccctt cctttccctc    240

cggcgtcctc tcccggccct ctcgcgctgc actgtctctc cgacgcaaga ttctcctggc    300

ccggatatgg ctcgtggaca gcagaaaatt cagtctcagc agaataatgc caaaaagcaa    360

gctggacaaa agaagaaaca aggacatgac caaaaggctg ctgccaaagc tgccttaata    420

tatacctgca ctgtctgtag gtgaattcac gacacctttg actcttctac tgtctcagac    480

cttaggtaac atacctgcag ctgcttttct aacaaactgt tgatcagcaa aaataaaggg    540

gctacagaaa cactcatttt ttatgctgtt cccttttggg cttcatgcaa agacaattct    600

gtgtaaatgt acagttgact ctgatttgga aatatgaaaa tcagtccatc cttgttataa    660

aaaaattttt tacaattgta attatattga tgttcatatt gtgtaaaata actcatttaa    720

taaaatagta ctttgattta cga                                            743


<210>  7274
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  7274

Met Lys Leu Ile Ile Gly Leu Asn Ser Gly Gly Ser Phe Gln Val Leu 
1               5                   10                  15      


Thr Ser Lys Cys Ile Pro Ala Val Gln Asn Ala Val Ala Ile Thr Gly 
            20                  25                  30          


Met Cys Glu Leu Ala His Gln Ser Lys Arg Leu Arg Arg Arg Arg Ala 
        35                  40                  45              


Arg Glu Ala Val Val Leu Pro Ala Leu Leu Phe Pro Leu Leu Ser Gly 
    50                  55                  60                  


Trp Arg Arg Pro Lys Arg Cys Trp Ala Arg Ser Pro Phe Leu Ser Leu 
65                  70                  75                  80  


Arg Arg Pro Leu Pro Ala Leu Ser Arg Cys Thr Val Ser Pro Thr Gln 
                85                  90                  95      


Asp Ser Pro Gly Pro Asp Met Ala Arg Gly Gln Gln Lys Ile Gln Ser 
            100                 105                 110         


Gln Gln Asn Asn Ala Lys Lys Gln Ala Gly Gln Lys Lys Lys Gln Gly 
        115                 120                 125             


His Asp Gln Lys Ala Ala Ala Lys Ala Ala Leu Ile Tyr Thr Cys Thr 
    130                 135                 140                 


Val Cys Arg 
145         


<210>  7275
<211>  1440
<212>  DNA
<213>  Homosapiens

<400>  7275
ggggggggcg gggcctcggg actccgccca cgcctccgtc tcctccgcgc tccgccacag     60

ccggccgaca ccacaccagc cggggagccg ccgccgccgc cgccacctct gagcagccgg    120

ctgggagcga gagccgacag ctagtctgca agccaccgct gtcgccatgg ggagccgcgt    180

ctcgcgggaa gacttcgagt gggtctacac cgaccagccg cacgccgacc ggcgccggga    240

gatcctggca aagtatccag agataaagtc cttgatgaaa cctgatccca atttgatatg    300

gattataatt atgatggttc tcacccagtt gggtgcattt tacatagtaa aagacttgga    360

ctggaaatgg gtcatatttg gggcctatgc gtttggcagt tgcattaacc actcaatgac    420

tctggctatt catgagattg cccacaatgc tgcctttggc aactgcaaag caatgtggaa    480

tcgctggttt ggaatgtttg ctaatcttcc tattgggatt ccatattcaa tttcctttaa    540

gaggtatcac atggatcatc atcggtacct tggagctgat ggcgtcgatg tagatattcc    600

taccgatttt gagggctggt tcttctgtac cgctttcaga aagtttatat gggttattct    660

tcagcctctc ttttatgcct ttcgacctct gttcatcaac cccaaaccaa ttacgtatct    720

ggaagttatc aataccgtgg cacaggtcac ttttgacatt ttaatttatt actttttggg    780

aattaaatcc ttagtctaca tgttggcagc atctttactt ggcctgggtt tgcacccaat    840

ttctggacat tttatagctg agcattacat gttcttaaag ggtcatgaaa cttactcata    900

ttatgggcct ctgaatttac ttaccttcaa tgtgggttat cataatgaac atcatgattt    960

ccccaacatt cctggaaaaa gtcttccact ggtgaggaaa atagcagctg aatactatga   1020

caacctccct cactacaatt cctggataaa agtactgtat gattttgtga tggatgatac   1080

aataagtccc tactcaagaa tgaagaggca ccaaaaagga gagatggtgc tggagtaaat   1140

atcattagtg ccaaagggat tcttctccaa aactttagat gataaaatgc cgggcgtggc   1200

ggcacatgcc tgtaatccca gctacatggg aggctgaggt gggagaattg cttgaaccca   1260

ggaggcggag gcagaggctg cagtgaccca agattgtgcc actgcactcc accctgggca   1320

acagagcaag accccatctc aaaaataaat aaatatatat aaaaaataaa aagctatttc   1380

tagtttattt cactataaag ttttgcttta ttaaaaagct aataaacagc tattaatcac   1440


<210>  7276
<211>  323
<212>  PRT
<213>  Homosapiens

<400>  7276

Met Gly Ser Arg Val Ser Arg Glu Asp Phe Glu Trp Val Tyr Thr Asp 
1               5                   10                  15      


Gln Pro His Ala Asp Arg Arg Arg Glu Ile Leu Ala Lys Tyr Pro Glu 
            20                  25                  30          


Ile Lys Ser Leu Met Lys Pro Asp Pro Asn Leu Ile Trp Ile Ile Ile 
        35                  40                  45              


Met Met Val Leu Thr Gln Leu Gly Ala Phe Tyr Ile Val Lys Asp Leu 
    50                  55                  60                  


Asp Trp Lys Trp Val Ile Phe Gly Ala Tyr Ala Phe Gly Ser Cys Ile 
65                  70                  75                  80  


Asn His Ser Met Thr Leu Ala Ile His Glu Ile Ala His Asn Ala Ala 
                85                  90                  95      


Phe Gly Asn Cys Lys Ala Met Trp Asn Arg Trp Phe Gly Met Phe Ala 
            100                 105                 110         


Asn Leu Pro Ile Gly Ile Pro Tyr Ser Ile Ser Phe Lys Arg Tyr His 
        115                 120                 125             


Met Asp His His Arg Tyr Leu Gly Ala Asp Gly Val Asp Val Asp Ile 
    130                 135                 140                 


Pro Thr Asp Phe Glu Gly Trp Phe Phe Cys Thr Ala Phe Arg Lys Phe 
145                 150                 155                 160 


Ile Trp Val Ile Leu Gln Pro Leu Phe Tyr Ala Phe Arg Pro Leu Phe 
                165                 170                 175     


Ile Asn Pro Lys Pro Ile Thr Tyr Leu Glu Val Ile Asn Thr Val Ala 
            180                 185                 190         


Gln Val Thr Phe Asp Ile Leu Ile Tyr Tyr Phe Leu Gly Ile Lys Ser 
        195                 200                 205             


Leu Val Tyr Met Leu Ala Ala Ser Leu Leu Gly Leu Gly Leu His Pro 
    210                 215                 220                 


Ile Ser Gly His Phe Ile Ala Glu His Tyr Met Phe Leu Lys Gly His 
225                 230                 235                 240 


Glu Thr Tyr Ser Tyr Tyr Gly Pro Leu Asn Leu Leu Thr Phe Asn Val 
                245                 250                 255     


Gly Tyr His Asn Glu His His Asp Phe Pro Asn Ile Pro Gly Lys Ser 
            260                 265                 270         


Leu Pro Leu Val Arg Lys Ile Ala Ala Glu Tyr Tyr Asp Asn Leu Pro 
        275                 280                 285             


His Tyr Asn Ser Trp Ile Lys Val Leu Tyr Asp Phe Val Met Asp Asp 
    290                 295                 300                 


Thr Ile Ser Pro Tyr Ser Arg Met Lys Arg His Gln Lys Gly Glu Met 
305                 310                 315                 320 


Val Leu Glu 
            


<210>  7277
<211>  1824
<212>  DNA
<213>  Homosapiens

<400>  7277
ggggggggcg gggcctcggg actccgccca cgcctccgtc tcctccgcgc tccgccacag     60

ccggccgaca ccacaccagc cggggagccg ccgccgccgc cgccacctct gagcagccgg    120

ctgggagcga gagccgacag ctagtctgca agccaccgct gtcgccatgg ggagccgcgt    180

ctcgcgggaa gacttcgagt gggtctacac cgaccagccg cacgccgacc ggcgccggga    240

gatcctggca aagtatccag agataaagtc cttgatgaaa cctgatccca atttgatatg    300

gattataatt atgatggttc tcacccagtt gggtgcattt tacatagtaa aagacttgga    360

ctggaaatgg gtcatatttg gggcctatgc gtttggcagt tgcattaacc actcaatgac    420

tctggctatt catgagattg cccacaatgc tgcctttggc aactgcaaag caatgtggaa    480

tcgctggttt ggaatgtttg ctaatcttcc tattgggatt ccatattcaa tttcctttaa    540

gaggtatcac atggatcatc atcggtacct tggagctgat ggcgtcgatg tagatattcc    600

taccgatttt gagggctggt tcttctgtac cgctttcaga aagtttatat gggttattct    660

tcagcctctc ttttatgcct ttcgacctct gttcatcaac cccaaaccaa ttacgtatct    720

ggaagttatc aataccgtgg cacaggtcac ttttgacatt ttaatttatt actttttggg    780

aattaaatcc ttagtctaca tgttggcagc atctttactt ggcctgggtt tgcacccaat    840

ttctggacat tttatagctg agcattacat gttcttaaag ggtcatgaaa cttactcata    900

ttatgggcct ctgaatttac ttaccttcaa tgtgggttat cataatgaac atcatgattt    960

ccccaacatt cctggaaaaa gtcttccact ggtgaggaaa atagcagctg aatactatga   1020

caacctccct cactacaatt cctggataaa agtactgtat gattttgtga tggatgatac   1080

aataagtccc tactcaagaa tgaagaggca ccaaaaagga gagatggtgc tggagtaaat   1140

atcattagtg ccaaagggat tcttctccaa aactttagat gataaaatgg aatttttgca   1200

ttattaaact tgagaccagt gatgctcaga agctcccctg gcacaatttc agagtaagag   1260

ctcggtgata ccaagaagtg aatctggctt ttaaacagtc agcctgactc tgtactgctc   1320

agtttcactc acaggaaact tgtgacttgt gtattatcgt cattgaggat gtttcactca   1380

tgtctgtcat tttataagca tatcatttaa aaagcttcta aaaagctatt tcgccaggca   1440

cggtggctca tgcctataat cccagcactt tgggaggcca aggtgggtgg atcacctgag   1500

gtcaggagtt cgagaccagc ctggccaaca cggtgaaacc ccatctctac taaaaatgca   1560

aaaattagcc gggcgtggcg gcacatgcct gtaatcccag ctacatggga ggctgaggtg   1620

ggagaattgc ttgaacccag gaggcggagg cagaggctgc agtgacccaa gattgtgcca   1680

ctgcactcca ccctgggcaa cagagcaaga ccccatctca aaaataaata aatatatata   1740

aaaaataaaa agctatttct agtttatttc actataaagt tttgctttat taaaaagcta   1800

ataaacagct attaatcaca gtgt                                          1824


<210>  7278
<211>  323
<212>  PRT
<213>  Homosapiens

<400>  7278

Met Gly Ser Arg Val Ser Arg Glu Asp Phe Glu Trp Val Tyr Thr Asp 
1               5                   10                  15      


Gln Pro His Ala Asp Arg Arg Arg Glu Ile Leu Ala Lys Tyr Pro Glu 
            20                  25                  30          


Ile Lys Ser Leu Met Lys Pro Asp Pro Asn Leu Ile Trp Ile Ile Ile 
        35                  40                  45              


Met Met Val Leu Thr Gln Leu Gly Ala Phe Tyr Ile Val Lys Asp Leu 
    50                  55                  60                  


Asp Trp Lys Trp Val Ile Phe Gly Ala Tyr Ala Phe Gly Ser Cys Ile 
65                  70                  75                  80  


Asn His Ser Met Thr Leu Ala Ile His Glu Ile Ala His Asn Ala Ala 
                85                  90                  95      


Phe Gly Asn Cys Lys Ala Met Trp Asn Arg Trp Phe Gly Met Phe Ala 
            100                 105                 110         


Asn Leu Pro Ile Gly Ile Pro Tyr Ser Ile Ser Phe Lys Arg Tyr His 
        115                 120                 125             


Met Asp His His Arg Tyr Leu Gly Ala Asp Gly Val Asp Val Asp Ile 
    130                 135                 140                 


Pro Thr Asp Phe Glu Gly Trp Phe Phe Cys Thr Ala Phe Arg Lys Phe 
145                 150                 155                 160 


Ile Trp Val Ile Leu Gln Pro Leu Phe Tyr Ala Phe Arg Pro Leu Phe 
                165                 170                 175     


Ile Asn Pro Lys Pro Ile Thr Tyr Leu Glu Val Ile Asn Thr Val Ala 
            180                 185                 190         


Gln Val Thr Phe Asp Ile Leu Ile Tyr Tyr Phe Leu Gly Ile Lys Ser 
        195                 200                 205             


Leu Val Tyr Met Leu Ala Ala Ser Leu Leu Gly Leu Gly Leu His Pro 
    210                 215                 220                 


Ile Ser Gly His Phe Ile Ala Glu His Tyr Met Phe Leu Lys Gly His 
225                 230                 235                 240 


Glu Thr Tyr Ser Tyr Tyr Gly Pro Leu Asn Leu Leu Thr Phe Asn Val 
                245                 250                 255     


Gly Tyr His Asn Glu His His Asp Phe Pro Asn Ile Pro Gly Lys Ser 
            260                 265                 270         


Leu Pro Leu Val Arg Lys Ile Ala Ala Glu Tyr Tyr Asp Asn Leu Pro 
        275                 280                 285             


His Tyr Asn Ser Trp Ile Lys Val Leu Tyr Asp Phe Val Met Asp Asp 
    290                 295                 300                 


Thr Ile Ser Pro Tyr Ser Arg Met Lys Arg His Gln Lys Gly Glu Met 
305                 310                 315                 320 


Val Leu Glu 
            


<210>  7279
<211>  2101
<212>  DNA
<213>  Homosapiens

<400>  7279
ggggggggcg gggcctcggg actccgccca cgcctccgtc tcctccgcgc tccgccacag     60

ccggccgaca ccacaccagc cggggagccg ccgccgccgc cgccacctct gagcagccgg    120

ctgggagcga gagccgacag ctagtctgca agccaccgct gtcgccatgg ggagccgcgt    180

ctcgcgggaa gacttcgagt gggtctacac cgaccagccg cacgccgacc ggcgccggga    240

gatcctggca aagtatccag agataaagtc cttgatgaaa cctgatccca atttgatatg    300

gattataatt atgatggttc tcacccagtt gggtgcattt tacatagtaa aagacttgga    360

ctggaaatgg gtcatatttg gggcctatgc gtttggcagt tgcattaacc actcaatgac    420

tctggctatt catgagattg cccacaatgc tgcctttggc aactgcaaag caatgtggaa    480

tcgctggttt ggaatgtttg ctaatcttcc tattgggatt ccatattcaa tttcctttaa    540

gaggtatcac atggatcatc atcggtacct tggagctgat ggcgtcgatg tagatattcc    600

taccgatttt gagggctggt tcttctgtac cgctttcaga aagtttatat gggttattct    660

tcagcctctc ttttatgcct ttcgacctct gttcatcaac cccaaaccaa ttacgtatct    720

ggaagttatc aataccgtgg cacaggtcac ttttgacatt ttaatttatt actttttggg    780

aattaaatcc ttagtctaca tgttggcagc atctttactt ggcctgggtt tgcacccaat    840

ttctggacat tttatagctg agcattacat gttcttaaag ggtcatgaaa cttactcata    900

ttatgggcct ctgaatttac ttaccttcaa tgtgggttat cataatgaac atcatgattt    960

ccccaacatt cctggaaaaa gtcttccact ggtgaggaaa atagcagctg aatactatga   1020

caacctccct cactacaatt cctggataaa agtactgtat gattttgtga tggatgatac   1080

aataagtccc tactcaagaa tgaagaggca ccaaaaagga gagatggtgc tggagtaaat   1140

atcattagtg ccaaagggat tcttctccaa aactttagat gataaaatgg aatttttgca   1200

ttattaaact tgagaccagt gatgctcaga agctcccctg gcacaatttc agagtaagag   1260

ctcggtgata ccaagaagtg aatctggctt ttaaacagtc agcctgactc tgtactgctc   1320

agtttcactc acaggaaact tgtgacttgt gtattatcgt cattgaggat gtttcactca   1380

tgtctgtcat tttataagca tatcatttaa aaagcttcta aaaagctatt tcgccaggca   1440

cggtggctca tgcctataat cccagcactt tgggaggcca aggtgggtgg atcacctgag   1500

gtcaggagtt cgagaccagc ctggccaaca cggtgaaacc ccatctctac taaaaatgca   1560

aaaattagcc gggcgtggcg gcacatgcct gtaatcccag ctacatggga ggctgaggtg   1620

ggagaattgc ttgaacccag gaggcggagg cagaggctgc agtgacccaa gattgtgcca   1680

ctgcactcca ccctgggcaa cagagcaaga ccccatctca aaaataaata aatatatata   1740

aaaaataaaa agctatttct agtttatttc actataaagt tttgctttat taaaaagcta   1800

ataaacagct attaatcaca gtgtattagt atttgttaca tttttgtatt tcactatctt   1860

tatactatat aatatggtaa cttgggtacc gggggaactt taaaatttca tctcaaaaat   1920

aatttttaaa aagcctgagg tatgatatag cataaaagat tgagatgaaa atatatttcc   1980

ctgtaagctg aattactcat ttaaaaattt taacttctat atgggacccg aattagacac   2040

tgctgaatcc tgtacagcct tactcataaa taaagtactt actgaatttc caccattcaa   2100

a                                                                   2101


<210>  7280
<211>  323
<212>  PRT
<213>  Homosapiens

<400>  7280

Met Gly Ser Arg Val Ser Arg Glu Asp Phe Glu Trp Val Tyr Thr Asp 
1               5                   10                  15      


Gln Pro His Ala Asp Arg Arg Arg Glu Ile Leu Ala Lys Tyr Pro Glu 
            20                  25                  30          


Ile Lys Ser Leu Met Lys Pro Asp Pro Asn Leu Ile Trp Ile Ile Ile 
        35                  40                  45              


Met Met Val Leu Thr Gln Leu Gly Ala Phe Tyr Ile Val Lys Asp Leu 
    50                  55                  60                  


Asp Trp Lys Trp Val Ile Phe Gly Ala Tyr Ala Phe Gly Ser Cys Ile 
65                  70                  75                  80  


Asn His Ser Met Thr Leu Ala Ile His Glu Ile Ala His Asn Ala Ala 
                85                  90                  95      


Phe Gly Asn Cys Lys Ala Met Trp Asn Arg Trp Phe Gly Met Phe Ala 
            100                 105                 110         


Asn Leu Pro Ile Gly Ile Pro Tyr Ser Ile Ser Phe Lys Arg Tyr His 
        115                 120                 125             


Met Asp His His Arg Tyr Leu Gly Ala Asp Gly Val Asp Val Asp Ile 
    130                 135                 140                 


Pro Thr Asp Phe Glu Gly Trp Phe Phe Cys Thr Ala Phe Arg Lys Phe 
145                 150                 155                 160 


Ile Trp Val Ile Leu Gln Pro Leu Phe Tyr Ala Phe Arg Pro Leu Phe 
                165                 170                 175     


Ile Asn Pro Lys Pro Ile Thr Tyr Leu Glu Val Ile Asn Thr Val Ala 
            180                 185                 190         


Gln Val Thr Phe Asp Ile Leu Ile Tyr Tyr Phe Leu Gly Ile Lys Ser 
        195                 200                 205             


Leu Val Tyr Met Leu Ala Ala Ser Leu Leu Gly Leu Gly Leu His Pro 
    210                 215                 220                 


Ile Ser Gly His Phe Ile Ala Glu His Tyr Met Phe Leu Lys Gly His 
225                 230                 235                 240 


Glu Thr Tyr Ser Tyr Tyr Gly Pro Leu Asn Leu Leu Thr Phe Asn Val 
                245                 250                 255     


Gly Tyr His Asn Glu His His Asp Phe Pro Asn Ile Pro Gly Lys Ser 
            260                 265                 270         


Leu Pro Leu Val Arg Lys Ile Ala Ala Glu Tyr Tyr Asp Asn Leu Pro 
        275                 280                 285             


His Tyr Asn Ser Trp Ile Lys Val Leu Tyr Asp Phe Val Met Asp Asp 
    290                 295                 300                 


Thr Ile Ser Pro Tyr Ser Arg Met Lys Arg His Gln Lys Gly Glu Met 
305                 310                 315                 320 


Val Leu Glu 
            


<210>  7281
<211>  1722
<212>  DNA
<213>  Homosapiens

<400>  7281
ggggggggcg gggcctcggg actccgccca cgcctccgtc tcctccgcgc tccgccacag     60

ccggccgaca ccacaccagc cggggagccg ccgccgccgc cgccacctct gagcagccgg    120

ctgggagcga gagccgacag ctagtctgca agccaccgct gtcgccatgg ggagccgcgt    180

ctcgcgggaa gacttcgagt gggtctacac cgaccagccg cacgccgacc ggcgccggga    240

gatcctggca aagtatccag agataaagtc cttgatgaaa cctgatccca atttgatatg    300

gattataatt atgatggttc tcacccagtt gggtgcattt tacatagtaa aagacttgga    360

ctggaaatgg gtcatatttg gggcctatgc gtttggcagt tgcattaacc actcaatgac    420

tctggctatt catgagattg cccacaatgc tgcctttggc aactgcaaag caatgtggaa    480

tcgctggttt ggaatgtttg ctaatcttcc tattgggatt ccatattcaa tttcctttaa    540

gaggtatcac atggatcatc atcggtacct tggagctgat ggcgtcgatg tagatattcc    600

taccgatttt gagggctggt tcttctgtac cgctttcaga aagtttatat gggttattct    660

tcagcctctc ttttatgcct ttcgacctct gttcatcaac cccaaaccaa ttacgtatct    720

ggaagttatc aataccgtgg cacaggtcac ttttgacatt ttaatttatt actttttggg    780

aattaaatcc ttagtctaca tgttggcagc atctttactt ggcctgggtt tgcacccaat    840

ttctggacat tttatagctg agcattacat gttcttaaag ggtcatgaaa cttactcata    900

ttatgggcct ctgaatttac ttaccttcaa tgtgggttat cataatgaac atcatgattt    960

ccccaacatt cctggaaaaa gtcttccact ggtgaggaaa atagcagctg aatactatga   1020

caacctccct cactacaatt cctggataaa agtactgtat gattttgtga tggatgatac   1080

aataagtccc tactcaagaa tgaagaggca ccaaaaagga gagatggtgc tggagtaaat   1140

atcattagtg ccaaagggat tcttctccaa aactttagat gataaaatgc cgggcgtggc   1200

ggcacatgcc tgtaatccca gctacatggg aggctgaggt gggagaattg cttgaaccca   1260

ggaggcggag gcagaggctg cagtgaccca agattgtgcc actgcactcc accctgggca   1320

acagagcaag accccatctc aaaaataaat aaatatatat aaaaaataaa aagctatttc   1380

tagtttattt cactataaag ttttgcttta ttaaaaagct aataaacagc tattaatcac   1440

agtgtattag tatttgttac atttttgtat ttcactatct ttatactata taatatggta   1500

acttgggtac cgggggaact ttaaaatttc atctcaaaaa taatttttaa aaagcctgag   1560

gtatgatata gcataaaaga ttgagatgaa aatatatttc cctgtaagct gaattactca   1620

tttaaaaatt ttaacttcta tatgggaccc gaattagaca ctgctgaatc ctgtacagcc   1680

ttactcataa ataaagtact tactgaattt ccaccattca aa                      1722


<210>  7282
<211>  323
<212>  PRT
<213>  Homosapiens

<400>  7282

Met Gly Ser Arg Val Ser Arg Glu Asp Phe Glu Trp Val Tyr Thr Asp 
1               5                   10                  15      


Gln Pro His Ala Asp Arg Arg Arg Glu Ile Leu Ala Lys Tyr Pro Glu 
            20                  25                  30          


Ile Lys Ser Leu Met Lys Pro Asp Pro Asn Leu Ile Trp Ile Ile Ile 
        35                  40                  45              


Met Met Val Leu Thr Gln Leu Gly Ala Phe Tyr Ile Val Lys Asp Leu 
    50                  55                  60                  


Asp Trp Lys Trp Val Ile Phe Gly Ala Tyr Ala Phe Gly Ser Cys Ile 
65                  70                  75                  80  


Asn His Ser Met Thr Leu Ala Ile His Glu Ile Ala His Asn Ala Ala 
                85                  90                  95      


Phe Gly Asn Cys Lys Ala Met Trp Asn Arg Trp Phe Gly Met Phe Ala 
            100                 105                 110         


Asn Leu Pro Ile Gly Ile Pro Tyr Ser Ile Ser Phe Lys Arg Tyr His 
        115                 120                 125             


Met Asp His His Arg Tyr Leu Gly Ala Asp Gly Val Asp Val Asp Ile 
    130                 135                 140                 


Pro Thr Asp Phe Glu Gly Trp Phe Phe Cys Thr Ala Phe Arg Lys Phe 
145                 150                 155                 160 


Ile Trp Val Ile Leu Gln Pro Leu Phe Tyr Ala Phe Arg Pro Leu Phe 
                165                 170                 175     


Ile Asn Pro Lys Pro Ile Thr Tyr Leu Glu Val Ile Asn Thr Val Ala 
            180                 185                 190         


Gln Val Thr Phe Asp Ile Leu Ile Tyr Tyr Phe Leu Gly Ile Lys Ser 
        195                 200                 205             


Leu Val Tyr Met Leu Ala Ala Ser Leu Leu Gly Leu Gly Leu His Pro 
    210                 215                 220                 


Ile Ser Gly His Phe Ile Ala Glu His Tyr Met Phe Leu Lys Gly His 
225                 230                 235                 240 


Glu Thr Tyr Ser Tyr Tyr Gly Pro Leu Asn Leu Leu Thr Phe Asn Val 
                245                 250                 255     


Gly Tyr His Asn Glu His His Asp Phe Pro Asn Ile Pro Gly Lys Ser 
            260                 265                 270         


Leu Pro Leu Val Arg Lys Ile Ala Ala Glu Tyr Tyr Asp Asn Leu Pro 
        275                 280                 285             


His Tyr Asn Ser Trp Ile Lys Val Leu Tyr Asp Phe Val Met Asp Asp 
    290                 295                 300                 


Thr Ile Ser Pro Tyr Ser Arg Met Lys Arg His Gln Lys Gly Glu Met 
305                 310                 315                 320 


Val Leu Glu 
            


<210>  7283
<211>  985
<212>  DNA
<213>  Homosapiens

<400>  7283
ccgccgccac ctctgagcag ccggctggga gcgagagccg acagctagtc tgcaagccac     60

cgctgtcgcc atggggagcc gcgtctcgcg ggaagacttc gagtgggtct acaccgacca    120

gccgcacgcc gaccggcgcc gggagatcct gggtgaggaa aatagcagct gaatactatg    180

acaacctccc tcactacaat tcctggataa aagtactgta tgattttgtg atggatgata    240

caataagtcc ctactcaaga atgaagaggc accaaaaagg agagatggtg ctggagtaaa    300

tatcattagt gccaaaggga ttcttctcca aaactttaga tgataaaatg gaatttttgc    360

attattaaac ttgagaccag tgatgctcag aagctcccct ggcacaattt cagagtaaga    420

gctcggtgat accaagaagt gaatctggct tttaaacagt cagcctgact ctgtactgct    480

cagtttcact cacaggaaac ttgtgacttg tgtattatcg tcattgagga tgtttcactc    540

atgtctgtca ttttataagc atatcattta aaaagcttct aaaaagctat ttcgccaggc    600

acggtggctc atgcctataa tcccagcact ttgggaggcc aaggtgggtg gatcacctga    660

ggtcaggagt tcgagaccag cctggccaac acggtgaaac cccatctcta ctaaaaatgc    720

aaaaattagc cgggcgtggc ggcacatgcc tgtaatccca gctacatggg aggctgaggt    780

gggagaattg cttgaaccca ggaggcggag gcagaggctg cagtgaccca agattgtgcc    840

actgcactcc accctgggca acagagcaag accccatctc aaaaataaat aaatatatat    900

aaaaaataaa aagctatttc tagtttattt cactataaag ttttgcttta ttaaaaagct    960

aataaacagc tattaatcac agtgt                                          985


<210>  7284
<211>  33
<212>  PRT
<213>  Homosapiens

<400>  7284

Met Gly Ser Arg Val Ser Arg Glu Asp Phe Glu Trp Val Tyr Thr Asp 
1               5                   10                  15      


Gln Pro His Ala Asp Arg Arg Arg Glu Ile Leu Gly Glu Glu Asn Ser 
            20                  25                  30          


Ser 
    


<210>  7285
<211>  1262
<212>  DNA
<213>  Homosapiens

<400>  7285
ccgccgccac ctctgagcag ccggctggga gcgagagccg acagctagtc tgcaagccac     60

cgctgtcgcc atggggagcc gcgtctcgcg ggaagacttc gagtgggtct acaccgacca    120

gccgcacgcc gaccggcgcc gggagatcct gggtgaggaa aatagcagct gaatactatg    180

acaacctccc tcactacaat tcctggataa aagtactgta tgattttgtg atggatgata    240

caataagtcc ctactcaaga atgaagaggc accaaaaagg agagatggtg ctggagtaaa    300

tatcattagt gccaaaggga ttcttctcca aaactttaga tgataaaatg gaatttttgc    360

attattaaac ttgagaccag tgatgctcag aagctcccct ggcacaattt cagagtaaga    420

gctcggtgat accaagaagt gaatctggct tttaaacagt cagcctgact ctgtactgct    480

cagtttcact cacaggaaac ttgtgacttg tgtattatcg tcattgagga tgtttcactc    540

atgtctgtca ttttataagc atatcattta aaaagcttct aaaaagctat ttcgccaggc    600

acggtggctc atgcctataa tcccagcact ttgggaggcc aaggtgggtg gatcacctga    660

ggtcaggagt tcgagaccag cctggccaac acggtgaaac cccatctcta ctaaaaatgc    720

aaaaattagc cgggcgtggc ggcacatgcc tgtaatccca gctacatggg aggctgaggt    780

gggagaattg cttgaaccca ggaggcggag gcagaggctg cagtgaccca agattgtgcc    840

actgcactcc accctgggca acagagcaag accccatctc aaaaataaat aaatatatat    900

aaaaaataaa aagctatttc tagtttattt cactataaag ttttgcttta ttaaaaagct    960

aataaacagc tattaatcac agtgtattag tatttgttac atttttgtat ttcactatct   1020

ttatactata taatatggta acttgggtac cgggggaact ttaaaatttc atctcaaaaa   1080

taatttttaa aaagcctgag gtatgatata gcataaaaga ttgagatgaa aatatatttc   1140

cctgtaagct gaattactca tttaaaaatt ttaacttcta tatgggaccc gaattagaca   1200

ctgctgaatc ctgtacagcc ttactcataa ataaagtact tactgaattt ccaccattca   1260

aa                                                                  1262


<210>  7286
<211>  33
<212>  PRT
<213>  Homosapiens

<400>  7286

Met Gly Ser Arg Val Ser Arg Glu Asp Phe Glu Trp Val Tyr Thr Asp 
1               5                   10                  15      


Gln Pro His Ala Asp Arg Arg Arg Glu Ile Leu Gly Glu Glu Asn Ser 
            20                  25                  30          


Ser 
    


<210>  7287
<211>  534
<212>  DNA
<213>  Homosapiens

<400>  7287
cctagtgcaa gcctgccaaa agcatctgta gaatgaataa atgaatacat aaatgcattt     60

tttgcatgga tttaaacatt aatgtttcat atttgaattt tagattcaag agttggaaaa    120

aaacagagac ctagccaaaa tgctggcata caggaaatgg ttaatgaggc agtagagtat    180

gtatgtagta ataggaacat gtgtttttca ttctcattac tgtttcagga cgaggctcat    240

aatgtaagcc aaatggaata tggttaaggc ttttgggtct ggagtccaca gagtctgcat    300

ttcaggttca gtttctgcag tttactaagt gtgaccttcg gccagttact taatctctct    360

aagccttttc tgtcatctac aaaatgaaga tattaatagt actgcttata gcatataaat    420

gttgagactt aaatacaata aattgtggtt catacctgta atcccagcac tttgggaggc    480

cgaggtggga ggattgcttg accctgggag gcggaggttg cagtgagctg agat          534


<210>  7288
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  7288

Met Leu Arg Leu Lys Tyr Asn Lys Leu Trp Phe Ile Pro Val Ile Pro 
1               5                   10                  15      


Ala Leu Trp Glu Ala Glu Val Gly Gly Leu Leu Asp Pro Gly Arg Arg 
            20                  25                  30          


Arg Leu Gln 
        35  


<210>  7289
<211>  437
<212>  DNA
<213>  Homosapiens

<400>  7289
ttcgggagct gcagaacttc agtgtccatc agtcagaggc aatgcccctg acccagacgc     60

ctctagttga gagatagaca gagctggatt tatagcacca cagacctgac ctggaatgag    120

acttgcaagt atgtcaggga gctgcacgct aacctaggaa gaggctggcc agatggaatc    180

ttgctctgtt gcccaggcta gaatgcagtg gcgtgatctt ggctcaccaa aaattctgcc    240

tcctgggttc aagtgcctcc acacccagct aattttgtat ttttagtaga gacgagattt    300

caccatgttg gccaggctag tcttgaactc ctgacattgt gatccaccca cctcagcctc    360

ccaaagtgct aagattacag gtgtgagcca ccatgcccgg cctacctgga gcattattaa    420

aaccttaaac ctttaaa                                                   437


<210>  7290
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  7290

Met Glu Ser Cys Ser Val Ala Gln Ala Arg Met Gln Trp Arg Asp Leu 
1               5                   10                  15      


Gly Ser Pro Lys Ile Leu Pro Pro Gly Phe Lys Cys Leu His Thr Gln 
            20                  25                  30          


Leu Ile Leu Tyr Phe 
        35          


<210>  7291
<211>  787
<212>  DNA
<213>  Homosapiens

<400>  7291
gttttctgag actgcatcca ctttgatagt ttctactgag tccaaattag aacatcccag     60

ctggtgggct gtctcccagg aagccctcgg agaggagcgg tgcatagggg gcacctggac    120

acagcccacc tcccccgagt agcgtcaggt aggcttgtct atctacatcc tttcgccctt    180

tctcaggaaa ctatcagatg atgtgctccc ccagatgaag aagtagtgcc aggaaaaagg    240

agacacggga tacagggatc ctgaagccgg cggaggacaa gggagctcct gggaggacag    300

ctgtgctccg gcctagcaat agcgagcagc tggtccagac tgccgccgtg actcagaaga    360

tagacatgcg gagggttatg atcacagagc aacgatggtc cttgtacatg aagataaaaa    420

tgctcaggtg tgcccaggtt gaagaagatg aaaggccctg cctcccagag cgcccgggga    480

cactggtgat ctcttccagg tctgtttcca cccactgcag ctgtgatgga atcttgctct    540

gttgcccagg ctagaatgca gtggcgtgat cttggctcac caaaaattct gcctcctggg    600

ttcaagtgcc tccacaccca gctaattttg tatttttagt agagacgaga tttcaccatg    660

ttggccaggc tagtcttgaa ctcctgacat tgtgatccac ccacctcagc ctcccaaagt    720

gctaagatta caggtgtgag ccaccatgcc cggcctacct ggagcattat taaaacctta    780

aaccttt                                                              787


<210>  7292
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  7292

Met Arg Arg Val Met Ile Thr Glu Gln Arg Trp Ser Leu Tyr Met Lys 
1               5                   10                  15      


Ile Lys Met Leu Arg Cys Ala Gln Val Glu Glu Asp Glu Arg Pro Cys 
            20                  25                  30          


Leu Pro Glu Arg Pro Gly Thr Leu Val Ile Ser Ser Arg Ser Val Ser 
        35                  40                  45              


Thr His Cys Ser Cys Asp Gly Ile Leu Leu Cys Cys Pro Gly 
    50                  55                  60          


<210>  7293
<211>  1322
<212>  DNA
<213>  Homosapiens

<400>  7293
gaacaaaggg gatggatttc agaaacgttt ctaaatcata aatgactgaa ccagaagaac     60

tgaagctgat gtcagatttc tcgcttgggt gatgaggaac aaggcaggaa gagcagcaat    120

gaggatagag gtggaagggc agctcaggaa tttccctgga gttttcccat cttgagactt    180

cggtcttgga agacagaatg gctgtgacat aatgtggact ttttacttcc acctctagga    240

aagcgttctt tggaacacct ttgctgagtc tctctctcct ccgctcaagg gattccgctg    300

acacattgca ttcttgggag aaccttccaa ttccaattat ggactagctg ctcctaccct    360

gtgctcttcg cttggtgact attcttatcc cttttcagcc cttctcacac tgttttgtga    420

ctgtctcttt atctgtatta agttggatat gaatttggct cctttcacac agaccaaaat    480

ataaatagct taagcaatat aaagatcaca cacacaagtg aggcaaatga ccatctgagg    540

gttgaggaaa ctctgctgca agggttgccc acgatcctgg tttcttgtgt tttattactt    600

tgtcattccc taggatgttg tctccattta caaggccaaa acaggttcat catcagctca    660

tcactctcta gtcccgggaa gggcagcatg gagttaaaat gacagaggaa gaaggcattt    720

tcacacaagg ctggccagat gggaagaatc ttcagcttca gcttcagctt ggcctcattc    780

atttgaaaat aaaatgttta catgaggccg cgcctgtgtc cagctgaaag tgggtccttc    840

agagcgtgtg ggggattctc tgccggcttg atgggctagc tcctctaagc cggctgctgg    900

agacatcacc ggctgaggga ctcctgcaaa cgttcataca tgatttgatc ctgaaaggag    960

ggagaacaca gaatacagag accgtcactg cttgttttgg gctgaatggt gccccccaaa   1020

attcacatgc tgcagtccgc acccgcagga cctcagaatg tgattgtaac tggagagagg   1080

gtctttatag aggagactgg attaaaatga ggtcatacag gtagactctt atccaatatg   1140

actgctctcc ttacaaaaag aggggattag ggcacaggag ggaagagcat gtgcgcagag   1200

ggaaaagcac atgcaggcgc tgggagaaga cagccatcag tgaggacaaa ggctccagaa   1260

gaaccaatcc tgcccaacac tctccagaac tgtgagaaaa taaattttcc actttttaag   1320

cc                                                                  1322


<210>  7294
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  7294

Met Thr Glu Glu Glu Gly Ile Phe Thr Gln Gly Trp Pro Asp Gly Lys 
1               5                   10                  15      


Asn Leu Gln Leu Gln Leu Gln Leu Gly Leu Ile His Leu Lys Ile Lys 
            20                  25                  30          


Cys Leu His Glu Ala Ala Pro Val Ser Ser 
        35                  40          


<210>  7295
<211>  639
<212>  DNA
<213>  Homosapiens

<400>  7295
tgagccatcg cacccggcat ggtctttaaa gctccaatga aaaatcattt ttctctctta     60

cttagaatgg taccaaacca ccactggatg cagatgtaaa tttggaagca attgctggtg    120

accttcgctg tgattgctat acgggcgcag atctctctgc tttggtacga gaagcttcta    180

tctgtgccct gagacaggaa atggcaagac agaagagtgg aaatgaaaaa ggtgaactca    240

aggttagtca taagcatttt gaagaagctt tcaagaaagt aagatcatct atatcaaaaa    300

aggatcaaat catgtatgaa cgtttgcagg agtccctcag ccggtgatgt ctccagcagc    360

cggcttagag gagctagccc atcaagccgg cagagaatcc cccacacgct ctgaaggacc    420

cactttcagc tggacacagg cgcggcctca tgtaaacatt ttattttcaa atgaatgagg    480

ccaagctgaa gctgaagctg aagattcttc ccatctggcc agccttgtgt gaaaatgcct    540

tcttcctctt taagaaaaag gacaattttt aaactgctga aataaaatga ctgttacatt    600

tttcaaataa aacttttact ttgaactatt ttgactata                           639


<210>  7296
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  7296

Met Ala Arg Gln Lys Ser Gly Asn Glu Lys Gly Glu Leu Lys Val Ser 
1               5                   10                  15      


His Lys His Phe Glu Glu Ala Phe Lys Lys Val Arg Ser Ser Ile Ser 
            20                  25                  30          


Lys Lys Asp Gln Ile Met Tyr Glu Arg Leu Gln Glu Ser Leu Ser Arg 
        35                  40                  45              


<210>  7297
<211>  2511
<212>  DNA
<213>  Homosapiens

<400>  7297
gcccagacct gcagggttcg tggataataa actcaagcag cgagtcatcc agtatagact     60

atggtcgaag aaaaagaaat gcttttagga ttcaggtaga aaaagtattt agcataatta    120

gtagtgagaa ggaacttaag aatttaacag aattagaaga tgaacatttg gcaaaaaggg    180

caagacaagg tgaagaggat aatgagtata ctgaaagcta ttctgatgat gattcaagta    240

tggaagacta cccagatcca caggattcaa aagattcttc tcttttggag agtgatatga    300

aacggaaagg caagctaaag aataaaggaa gcaaaaggaa gaaagaagat cttcaggaag    360

tagatggaga aattgaagct gtcctgcaaa agaaagctaa agccaggggg ttagaattcc    420

agatctccaa cgtgaagttt gaagatgtgg gaggcaatga tatgacatta aaagaggtct    480

gcaagatgct catacacatg cgtcacccgg aggtgtacca ccacctgggc gtcgtgcccc    540

ctcgtggagt tctccttcat ggaccaccag gctgtgggaa gacattactt gcacatgcaa    600

ttgctgggga acttgacctg ccaattttga aagtggctgc tccagagatt gtgtctggag    660

tatccggaga gtctgagcag aagctgagag aactatttga gcaagctgtg tcaaatgcac    720

catgtatcat tttcattgat gaaattgatg ctattacccc caaaagagaa gtggcttcaa    780

aagatatgga acgaagaatt gtagcccaac tcctaacctg catggatgat ctgaataatg    840

tggctgctac agcccgggtc ctagttattg gagctactaa tcgaccagac tcgttagacc    900

ctgctttgag acgtgcggga aggttcgacc gagaaatatg cctaggtatc ccagatgaag    960

catccaggga aagaatactt caaacattgt gcagaaaact gaggcttcct caagcttttg   1020

atttctgtca cttagcacac ctaactccag gctttgttgg tgctgatctc atggcactgt   1080

gccgagaggc agcaatgtgt gcagtcaata gagtcttaat gaagctacag gaacagcaga   1140

agaaaaatcc tgaaatggaa gatttgccat ctaaaggagt ccaggaggaa aggctgggaa   1200

ctgagcccac ttctgaaaca caggatgaat tacaaaggct gctggggttg ctaagagacc   1260

aagatcccct ctcagaggag cagatgcaag gactgtgcat tgaactgaat gatttcattg   1320

ttgctctatc ctcagtccaa ccctctgcca aaagggaagg ctttgtcact gtccctaatg   1380

tgacatgggc agatattggt gccctggaag acattagaga ggagctcacc atggcaatat   1440

tggcaccagt acgcaaccca gaccagttca aagctcttgg attggtgact ccagctgggg   1500

tcctccttgc tggtcctcct ggctgtggga agactctgct ggcgaaggct gttgcaaatg   1560

agtccggact aaattttata tctgtcaagg gccccgaatt actaaacatg tatgttggtg   1620

agagtgaacg tgctgtgcga caagtttttc aacgagccaa gaactcagca ccctgtgtga   1680

tattctttga tgaagtggat gctttatgtc ctcgaagatc agaccgagag acaggggcaa   1740

gtgtccgagt ggtgaatcag ctacttacag agatggatgg tctggaagca cgccagcagg   1800

tttttattat ggcagccact aacaggccag atataattga ccctgcaatc ctgcgcccgg   1860

gccgcctgga caaaacactg tttgtgggtt taccgccccc tgcagatcgc cttgccatct   1920

taaaaactat cacaaaaaat ggtaccaaac caccactgga tgcagatgta aatttggaag   1980

caattgctgg tgaccttcgc tgtgattgct atacgggcgc agatctctct gctttggtac   2040

gagaagcttc tatctgtgcc ctgagacagg aaatggcaag acagaagagt ggaaatgaaa   2100

aaggtgaact caaggttagt cataagcatt ttgaagaagc tttcaagaaa gtaagatcat   2160

ctatatcaaa aaaggatcaa atcatgtatg aacgtttgca ggagtccctc agccggtgat   2220

gtctccagca gccggcttag aggagctagc ccatcaagcc ggcagagaat cccccacacg   2280

ctctgaagga cccactttca gctggacaca ggcgcggcct catgtaaaca ttttattttc   2340

aaatgaatga ggccaagctg aagctgaagc tgaagattct tcccatctgg ccagccttgt   2400

gtgaaaatgc cttcttcctc tttaagaaaa aggacaattt ttaaactgct gaaataaaat   2460

gactgttaca tttttcaaat aaaactttta ctttgaacta ttttgactat a            2511


<210>  7298
<211>  659
<212>  PRT
<213>  Homosapiens

<400>  7298

Met Glu Asp Tyr Pro Asp Pro Gln Asp Ser Lys Asp Ser Ser Leu Leu 
1               5                   10                  15      


Glu Ser Asp Met Lys Arg Lys Gly Lys Leu Lys Asn Lys Gly Ser Lys 
            20                  25                  30          


Arg Lys Lys Glu Asp Leu Gln Glu Val Asp Gly Glu Ile Glu Ala Val 
        35                  40                  45              


Leu Gln Lys Lys Ala Lys Ala Arg Gly Leu Glu Phe Gln Ile Ser Asn 
    50                  55                  60                  


Val Lys Phe Glu Asp Val Gly Gly Asn Asp Met Thr Leu Lys Glu Val 
65                  70                  75                  80  


Cys Lys Met Leu Ile His Met Arg His Pro Glu Val Tyr His His Leu 
                85                  90                  95      


Gly Val Val Pro Pro Arg Gly Val Leu Leu His Gly Pro Pro Gly Cys 
            100                 105                 110         


Gly Lys Thr Leu Leu Ala His Ala Ile Ala Gly Glu Leu Asp Leu Pro 
        115                 120                 125             


Ile Leu Lys Val Ala Ala Pro Glu Ile Val Ser Gly Val Ser Gly Glu 
    130                 135                 140                 


Ser Glu Gln Lys Leu Arg Glu Leu Phe Glu Gln Ala Val Ser Asn Ala 
145                 150                 155                 160 


Pro Cys Ile Ile Phe Ile Asp Glu Ile Asp Ala Ile Thr Pro Lys Arg 
                165                 170                 175     


Glu Val Ala Ser Lys Asp Met Glu Arg Arg Ile Val Ala Gln Leu Leu 
            180                 185                 190         


Thr Cys Met Asp Asp Leu Asn Asn Val Ala Ala Thr Ala Arg Val Leu 
        195                 200                 205             


Val Ile Gly Ala Thr Asn Arg Pro Asp Ser Leu Asp Pro Ala Leu Arg 
    210                 215                 220                 


Arg Ala Gly Arg Phe Asp Arg Glu Ile Cys Leu Gly Ile Pro Asp Glu 
225                 230                 235                 240 


Ala Ser Arg Glu Arg Ile Leu Gln Thr Leu Cys Arg Lys Leu Arg Leu 
                245                 250                 255     


Pro Gln Ala Phe Asp Phe Cys His Leu Ala His Leu Thr Pro Gly Phe 
            260                 265                 270         


Val Gly Ala Asp Leu Met Ala Leu Cys Arg Glu Ala Ala Met Cys Ala 
        275                 280                 285             


Val Asn Arg Val Leu Met Lys Leu Gln Glu Gln Gln Lys Lys Asn Pro 
    290                 295                 300                 


Glu Met Glu Asp Leu Pro Ser Lys Gly Val Gln Glu Glu Arg Leu Gly 
305                 310                 315                 320 


Thr Glu Pro Thr Ser Glu Thr Gln Asp Glu Leu Gln Arg Leu Leu Gly 
                325                 330                 335     


Leu Leu Arg Asp Gln Asp Pro Leu Ser Glu Glu Gln Met Gln Gly Leu 
            340                 345                 350         


Cys Ile Glu Leu Asn Asp Phe Ile Val Ala Leu Ser Ser Val Gln Pro 
        355                 360                 365             


Ser Ala Lys Arg Glu Gly Phe Val Thr Val Pro Asn Val Thr Trp Ala 
    370                 375                 380                 


Asp Ile Gly Ala Leu Glu Asp Ile Arg Glu Glu Leu Thr Met Ala Ile 
385                 390                 395                 400 


Leu Ala Pro Val Arg Asn Pro Asp Gln Phe Lys Ala Leu Gly Leu Val 
                405                 410                 415     


Thr Pro Ala Gly Val Leu Leu Ala Gly Pro Pro Gly Cys Gly Lys Thr 
            420                 425                 430         


Leu Leu Ala Lys Ala Val Ala Asn Glu Ser Gly Leu Asn Phe Ile Ser 
        435                 440                 445             


Val Lys Gly Pro Glu Leu Leu Asn Met Tyr Val Gly Glu Ser Glu Arg 
    450                 455                 460                 


Ala Val Arg Gln Val Phe Gln Arg Ala Lys Asn Ser Ala Pro Cys Val 
465                 470                 475                 480 


Ile Phe Phe Asp Glu Val Asp Ala Leu Cys Pro Arg Arg Ser Asp Arg 
                485                 490                 495     


Glu Thr Gly Ala Ser Val Arg Val Val Asn Gln Leu Leu Thr Glu Met 
            500                 505                 510         


Asp Gly Leu Glu Ala Arg Gln Gln Val Phe Ile Met Ala Ala Thr Asn 
        515                 520                 525             


Arg Pro Asp Ile Ile Asp Pro Ala Ile Leu Arg Pro Gly Arg Leu Asp 
    530                 535                 540                 


Lys Thr Leu Phe Val Gly Leu Pro Pro Pro Ala Asp Arg Leu Ala Ile 
545                 550                 555                 560 


Leu Lys Thr Ile Thr Lys Asn Gly Thr Lys Pro Pro Leu Asp Ala Asp 
                565                 570                 575     


Val Asn Leu Glu Ala Ile Ala Gly Asp Leu Arg Cys Asp Cys Tyr Thr 
            580                 585                 590         


Gly Ala Asp Leu Ser Ala Leu Val Arg Glu Ala Ser Ile Cys Ala Leu 
        595                 600                 605             


Arg Gln Glu Met Ala Arg Gln Lys Ser Gly Asn Glu Lys Gly Glu Leu 
    610                 615                 620                 


Lys Val Ser His Lys His Phe Glu Glu Ala Phe Lys Lys Val Arg Ser 
625                 630                 635                 640 


Ser Ile Ser Lys Lys Asp Gln Ile Met Tyr Glu Arg Leu Gln Glu Ser 
                645                 650                 655     


Leu Ser Arg 
            


<210>  7299
<211>  2832
<212>  DNA
<213>  Homosapiens

<400>  7299
ctaggagctg gcggtccgag ctgtggcttg gaagaccgac gcgatgaagc ccagacctgc     60

agggttcgtg gataataaac tcaagcagcg agtcatccag tatagactat ggtcgaagaa    120

aaagaaatgc ttttaggatt caggtagaaa aagtatttag cataattagt agtgagaagg    180

aacttaagaa tttaacagaa ttagaagatg aacatttggc aaaaagggca agacaaggtg    240

aagaggataa tgagtatact gaaagctatt ctgatgatga ttcaagtatg gaagactacc    300

cagatccaca gtcagcaaat cacatgaaca gttccctgct gtctttatat cggaaaggaa    360

atcctgattc tgtttcaaat actcctgaga tggagcaaag agaaaccacc tcttcaacac    420

cacggataag ttccaaaaca ggctccattc ccttgaagac ccctgccaaa gattctgaag    480

gaggatggtt tattgacaaa accccaagtg taaagaaaga cagttttttc ttggacctgt    540

catgtgagaa aagtaatcct aagaagccaa taactgagat acaggattca aaagattctt    600

ctcttttgga gagtgatatg aaacggaaag gcaagctaaa gaataaagga agcaaaagga    660

agaaagaaga tcttcaggaa gtagatggag aaattgaagc tgtcctgcaa aagaaagcta    720

aagccagggg gttagaattc cagatctcca acgtgaagtt tgaagatgtg ggaggcaatg    780

atatgacatt aaaagaggtc tgcaagatgc tcatacacat gcgtcacccg gaggtgtacc    840

accacctggg cgtcgtgccc cctcgtggag ttctccttca tggaccacca ggctgtggga    900

agacattact tgcacatgca attgctgggg aacttgacct gccaattttg aaagtggctg    960

ctccagagat tgtgtctgga gtatccggag agtctgagca gaagctgaga gaactatttg   1020

agcaagctgt gtcaaatgca ccatgtatca ttttcattga tgaaattgat gctattaccc   1080

ccaaaagaga agtggcttca aaagatatgg aacgaagaat tgtagcccaa ctcctaacct   1140

gcatggatga tctgaataat gtggctgcta cagcccgggt cctagttatt ggagctacta   1200

atcgaccaga ctcgttagac cctgctttga gacgtgcggg aaggttcgac cgagaaatat   1260

gcctaggtat cccagatgaa gcatccaggg aaagaatact tcaaacattg tgcagaaaac   1320

tgaggcttcc tcaagctttt gatttctgtc acttagcaca cctaactcca ggctttgttg   1380

gtgctgatct catggcactg tgccgagagg cagcaatgtg tgcagtcaat agagtcttaa   1440

tgaagctaca ggaacagcag aagaaaaatc ctgaaatgga agatttgcca tctaaaggag   1500

tccaggagga aaggctggga actgagccca cttctgaaac acaggatgaa ttacaaaggc   1560

tgctggggtt gctaagagac caagatcccc tctcagagga gcagatgcaa ggactgtgca   1620

ttgaactgaa tgatttcatt gttgctctat cctcagtcca accctctgcc aaaagggaag   1680

gctttgtcac tgtccctaat gtgacatggg cagatattgg tgccctggaa gacattagag   1740

aggagctcac catggcaata ttggcaccag tacgcaaccc agaccagttc aaagctcttg   1800

gattggtgac tccagctggg gtcctccttg ctggtcctcc tggctgtggg aagactctgc   1860

tggcgaaggc tgttgcaaat gagtccggac taaattttat atctgtcaag ggccccgaat   1920

tactaaacat gtatgttggt gagagtgaac gtgctgtgcg acaagttttt caacgagcca   1980

agaactcagc accctgtgtg atattctttg atgaagtgga tgctttatgt cctcgaagat   2040

cagaccgaga gacaggggca agtgtccgag tggtgaatca gctacttaca gagatggatg   2100

gtctggaagc acgccagcag gtttttatta tggcagccac taacaggcca gatataattg   2160

accctgcaat cctgcgcccg ggccgcctgg acaaaacact gtttgtgggt ttaccgcccc   2220

ctgcagatcg ccttgccatc ttaaaaacta tcacaaaaaa tggtaccaaa ccaccactgg   2280

atgcagatgt aaatttggaa gcaattgctg gtgaccttcg ctgtgattgc tatacgggcg   2340

cagatctctc tgctttggta cgagaagctt ctatctgtgc cctgagacag gaaatggcaa   2400

gacagaagag tggaaatgaa aaaggtgaac tcaaggttag tcataagcat tttgaagaag   2460

ctttcaagaa agtaagatca tctatatcaa aaaaggatca aatcatgtat gaacgtttgc   2520

aggagtccct cagccggtga tgtctccagc agccggctta gaggagctag cccatcaagc   2580

cggcagagaa tcccccacac gctctgaagg acccactttc agctggacac aggcgcggcc   2640

tcatgtaaac attttatttt caaatgaatg aggccaagct gaagctgaag ctgaagattc   2700

ttcccatctg gccagccttg tgtgaaaatg ccttcttcct ctttaagaaa aaggacaatt   2760

tttaaactgc tgaaataaaa tgactgttac atttttcaaa taaaactttt actttgaact   2820

attttgacta ta                                                       2832


<210>  7300
<211>  750
<212>  PRT
<213>  Homosapiens

<400>  7300

Met Glu Asp Tyr Pro Asp Pro Gln Ser Ala Asn His Met Asn Ser Ser 
1               5                   10                  15      


Leu Leu Ser Leu Tyr Arg Lys Gly Asn Pro Asp Ser Val Ser Asn Thr 
            20                  25                  30          


Pro Glu Met Glu Gln Arg Glu Thr Thr Ser Ser Thr Pro Arg Ile Ser 
        35                  40                  45              


Ser Lys Thr Gly Ser Ile Pro Leu Lys Thr Pro Ala Lys Asp Ser Glu 
    50                  55                  60                  


Gly Gly Trp Phe Ile Asp Lys Thr Pro Ser Val Lys Lys Asp Ser Phe 
65                  70                  75                  80  


Phe Leu Asp Leu Ser Cys Glu Lys Ser Asn Pro Lys Lys Pro Ile Thr 
                85                  90                  95      


Glu Ile Gln Asp Ser Lys Asp Ser Ser Leu Leu Glu Ser Asp Met Lys 
            100                 105                 110         


Arg Lys Gly Lys Leu Lys Asn Lys Gly Ser Lys Arg Lys Lys Glu Asp 
        115                 120                 125             


Leu Gln Glu Val Asp Gly Glu Ile Glu Ala Val Leu Gln Lys Lys Ala 
    130                 135                 140                 


Lys Ala Arg Gly Leu Glu Phe Gln Ile Ser Asn Val Lys Phe Glu Asp 
145                 150                 155                 160 


Val Gly Gly Asn Asp Met Thr Leu Lys Glu Val Cys Lys Met Leu Ile 
                165                 170                 175     


His Met Arg His Pro Glu Val Tyr His His Leu Gly Val Val Pro Pro 
            180                 185                 190         


Arg Gly Val Leu Leu His Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu 
        195                 200                 205             


Ala His Ala Ile Ala Gly Glu Leu Asp Leu Pro Ile Leu Lys Val Ala 
    210                 215                 220                 


Ala Pro Glu Ile Val Ser Gly Val Ser Gly Glu Ser Glu Gln Lys Leu 
225                 230                 235                 240 


Arg Glu Leu Phe Glu Gln Ala Val Ser Asn Ala Pro Cys Ile Ile Phe 
                245                 250                 255     


Ile Asp Glu Ile Asp Ala Ile Thr Pro Lys Arg Glu Val Ala Ser Lys 
            260                 265                 270         


Asp Met Glu Arg Arg Ile Val Ala Gln Leu Leu Thr Cys Met Asp Asp 
        275                 280                 285             


Leu Asn Asn Val Ala Ala Thr Ala Arg Val Leu Val Ile Gly Ala Thr 
    290                 295                 300                 


Asn Arg Pro Asp Ser Leu Asp Pro Ala Leu Arg Arg Ala Gly Arg Phe 
305                 310                 315                 320 


Asp Arg Glu Ile Cys Leu Gly Ile Pro Asp Glu Ala Ser Arg Glu Arg 
                325                 330                 335     


Ile Leu Gln Thr Leu Cys Arg Lys Leu Arg Leu Pro Gln Ala Phe Asp 
            340                 345                 350         


Phe Cys His Leu Ala His Leu Thr Pro Gly Phe Val Gly Ala Asp Leu 
        355                 360                 365             


Met Ala Leu Cys Arg Glu Ala Ala Met Cys Ala Val Asn Arg Val Leu 
    370                 375                 380                 


Met Lys Leu Gln Glu Gln Gln Lys Lys Asn Pro Glu Met Glu Asp Leu 
385                 390                 395                 400 


Pro Ser Lys Gly Val Gln Glu Glu Arg Leu Gly Thr Glu Pro Thr Ser 
                405                 410                 415     


Glu Thr Gln Asp Glu Leu Gln Arg Leu Leu Gly Leu Leu Arg Asp Gln 
            420                 425                 430         


Asp Pro Leu Ser Glu Glu Gln Met Gln Gly Leu Cys Ile Glu Leu Asn 
        435                 440                 445             


Asp Phe Ile Val Ala Leu Ser Ser Val Gln Pro Ser Ala Lys Arg Glu 
    450                 455                 460                 


Gly Phe Val Thr Val Pro Asn Val Thr Trp Ala Asp Ile Gly Ala Leu 
465                 470                 475                 480 


Glu Asp Ile Arg Glu Glu Leu Thr Met Ala Ile Leu Ala Pro Val Arg 
                485                 490                 495     


Asn Pro Asp Gln Phe Lys Ala Leu Gly Leu Val Thr Pro Ala Gly Val 
            500                 505                 510         


Leu Leu Ala Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala Lys Ala 
        515                 520                 525             


Val Ala Asn Glu Ser Gly Leu Asn Phe Ile Ser Val Lys Gly Pro Glu 
    530                 535                 540                 


Leu Leu Asn Met Tyr Val Gly Glu Ser Glu Arg Ala Val Arg Gln Val 
545                 550                 555                 560 


Phe Gln Arg Ala Lys Asn Ser Ala Pro Cys Val Ile Phe Phe Asp Glu 
                565                 570                 575     


Val Asp Ala Leu Cys Pro Arg Arg Ser Asp Arg Glu Thr Gly Ala Ser 
            580                 585                 590         


Val Arg Val Val Asn Gln Leu Leu Thr Glu Met Asp Gly Leu Glu Ala 
        595                 600                 605             


Arg Gln Gln Val Phe Ile Met Ala Ala Thr Asn Arg Pro Asp Ile Ile 
    610                 615                 620                 


Asp Pro Ala Ile Leu Arg Pro Gly Arg Leu Asp Lys Thr Leu Phe Val 
625                 630                 635                 640 


Gly Leu Pro Pro Pro Ala Asp Arg Leu Ala Ile Leu Lys Thr Ile Thr 
                645                 650                 655     


Lys Asn Gly Thr Lys Pro Pro Leu Asp Ala Asp Val Asn Leu Glu Ala 
            660                 665                 670         


Ile Ala Gly Asp Leu Arg Cys Asp Cys Tyr Thr Gly Ala Asp Leu Ser 
        675                 680                 685             


Ala Leu Val Arg Glu Ala Ser Ile Cys Ala Leu Arg Gln Glu Met Ala 
    690                 695                 700                 


Arg Gln Lys Ser Gly Asn Glu Lys Gly Glu Leu Lys Val Ser His Lys 
705                 710                 715                 720 


His Phe Glu Glu Ala Phe Lys Lys Val Arg Ser Ser Ile Ser Lys Lys 
                725                 730                 735     


Asp Gln Ile Met Tyr Glu Arg Leu Gln Glu Ser Leu Ser Arg 
            740                 745                 750 


<210>  7301
<211>  2918
<212>  DNA
<213>  Homosapiens

<400>  7301
gcccccggtt gactaggagc tggcggtccg agctgtggct tggaagaccg acgcgatgaa     60

gcccagacct gcagggttcg tggataataa actcaagcag cgagtcatcc agtaccttac    120

cagtaacaaa tgtggcaaat atgtggacat tggagtctta gcgtctgatt tacaaagagt    180

gtacagtata gactatggtc gaagaaaaag aaatgctttt aggattcagg tagaaaaagt    240

atttagcata attagtagtg agaaggaact taagaattta acagaattag aagatgaaca    300

tttggcaaaa agggcaagac aaggtgaaga ggataatgag tatactgaaa gctattctga    360

tgatgattca agtatggaag actacccaga tccacagtca gcaaatcaca tgaacagttc    420

cctgctgtct ttatatcgga aaggaaatcc tgattctgtt tcaaatactc ctgagatgga    480

gcaaagagaa accacctctt caacaccacg gataagttcc aaaacaggct ccattccctt    540

gaagacccct gccaaagatt ctgaaggagg atggtttatt gacaaaaccc caagtgtaaa    600

gaaagacagt tttttcttgg acctgtcatg tgagaaaagt aatcctaaga agccaataac    660

tgagatacag gattcaaaag attcttctct tttggagagt gatatgaaac ggaaaggcaa    720

gctaaagaat aaaggaagca aaaggaagaa agaagatctt caggaagtag atggagaaat    780

tgaagctgtc ctgcaaaaga aagctaaagc cagggggtta gaattccaga tctccaacgt    840

gaagtttgaa gatgtgggag gcaatgatat gacattaaaa gaggtctgca agatgctcat    900

acacatgcgt cacccggagg tgtaccacca cctgggcgtc gtgccccctc gtggagttct    960

ccttcatgga ccaccaggct gtgggaagac attacttgca catgcaattg ctggggaact   1020

tgacctgcca attttgaaag tggctgctcc agagattgtg tctggagtat ccggagagtc   1080

tgagcagaag ctgagagaac tatttgagca agctgtgtca aatgcaccat gtatcatttt   1140

cattgatgaa attgatgcta ttacccccaa aagagaagtg gcttcaaaag atatggaacg   1200

aagaattgta gcccaactcc taacctgcat ggatgatctg aataatgtgg ctgctacagc   1260

ccgggtccta gttattggag ctactaatcg accagactcg ttagaccctg ctttgagacg   1320

tgcgggaagg ttcgaccgag aaatatgcct aggtatccca gatgaagcat ccagggaaag   1380

aatacttcaa acattgtgca gaaaactgag gcttcctcaa gcttttgatt tctgtcactt   1440

agcacaccta actccaggct ttgttggtgc tgatctcatg gcactgtgcc gagaggcagc   1500

aatgtgtgca gtcaatagag tcttaatgaa gctacaggaa cagcagaaga aaaatcctga   1560

aatggaagat ttgccatcta aaggagtcca ggaggaaagg ctgggaactg agcccacttc   1620

tgaaacacag gatgaattac aaaggctgct ggggttgcta agagaccaag atcccctctc   1680

agaggagcag atgcaaggac tgtgcattga actgaatgat ttcattgttg ctctatcctc   1740

agtccaaccc tctgccaaaa gggaaggctt tgtcactgtc cctaatgtga catgggcaga   1800

tattggtgcc ctggaagaca ttagagagga gctcaccatg gcaatattgg caccagtacg   1860

caacccagac cagttcaaag ctcttggatt ggtgactcca gctggggtcc tccttgctgg   1920

tcctcctggc tgtgggaaga ctctgctggc gaaggctgtt gcaaatgagt ccggactaaa   1980

ttttatatct gtcaagggcc ccgaattact aaacatgtat gttggtgaga gtgaacgtgc   2040

tgtgcgacaa gtttttcaac gagccaagaa ctcagcaccc tgtgtgatat tctttgatga   2100

agtggatgct ttatgtcctc gaagatcaga ccgagagaca ggggcaagtg tccgagtggt   2160

gaatcagcta cttacagaga tggatggtct ggaagcacgc cagcaggttt ttattatggc   2220

agccactaac aggccagata taattgaccc tgcaatcctg cgcccgggcc gcctggacaa   2280

aacactgttt gtgggtttac cgccccctgc agatcgcctt gccatcttaa aaactatcac   2340

aaaaaatggt accaaaccac cactggatgc agatgtaaat ttggaagcaa ttgctggtga   2400

ccttcgctgt gattgctata cgggcgcaga tctctctgct ttggtacgag aagcttctat   2460

ctgtgccctg agacaggaaa tggcaagaca gaagagtgga aatgaaaaag gtgaactcaa   2520

ggttagtcat aagcattttg aagaagcttt caagaaagta agatcatcta tatcaaaaaa   2580

ggatcaaatc atgtatgaac gtttgcagga gtccctcagc cggtgatgtc tccagcagcc   2640

ggcttagagg agctagccca tcaagccggc agagaatccc ccacacgctc tgaaggaccc   2700

actttcagct ggacacaggc gcggcctcat gtaaacattt tattttcaaa tgaatgaggc   2760

caagctgaag ctgaagctga agattcttcc catctggcca gccttgtgtg aaaatgcctt   2820

cttcctcttt aagaaaaagg acaattttta aactgctgaa ataaaatgac tgttacattt   2880

ttcaaataaa acttttactt tgaactattt tgactata                           2918


<210>  7302
<211>  856
<212>  PRT
<213>  Homosapiens

<400>  7302

Met Lys Pro Arg Pro Ala Gly Phe Val Asp Asn Lys Leu Lys Gln Arg 
1               5                   10                  15      


Val Ile Gln Tyr Leu Thr Ser Asn Lys Cys Gly Lys Tyr Val Asp Ile 
            20                  25                  30          


Gly Val Leu Ala Ser Asp Leu Gln Arg Val Tyr Ser Ile Asp Tyr Gly 
        35                  40                  45              


Arg Arg Lys Arg Asn Ala Phe Arg Ile Gln Val Glu Lys Val Phe Ser 
    50                  55                  60                  


Ile Ile Ser Ser Glu Lys Glu Leu Lys Asn Leu Thr Glu Leu Glu Asp 
65                  70                  75                  80  


Glu His Leu Ala Lys Arg Ala Arg Gln Gly Glu Glu Asp Asn Glu Tyr 
                85                  90                  95      


Thr Glu Ser Tyr Ser Asp Asp Asp Ser Ser Met Glu Asp Tyr Pro Asp 
            100                 105                 110         


Pro Gln Ser Ala Asn His Met Asn Ser Ser Leu Leu Ser Leu Tyr Arg 
        115                 120                 125             


Lys Gly Asn Pro Asp Ser Val Ser Asn Thr Pro Glu Met Glu Gln Arg 
    130                 135                 140                 


Glu Thr Thr Ser Ser Thr Pro Arg Ile Ser Ser Lys Thr Gly Ser Ile 
145                 150                 155                 160 


Pro Leu Lys Thr Pro Ala Lys Asp Ser Glu Gly Gly Trp Phe Ile Asp 
                165                 170                 175     


Lys Thr Pro Ser Val Lys Lys Asp Ser Phe Phe Leu Asp Leu Ser Cys 
            180                 185                 190         


Glu Lys Ser Asn Pro Lys Lys Pro Ile Thr Glu Ile Gln Asp Ser Lys 
        195                 200                 205             


Asp Ser Ser Leu Leu Glu Ser Asp Met Lys Arg Lys Gly Lys Leu Lys 
    210                 215                 220                 


Asn Lys Gly Ser Lys Arg Lys Lys Glu Asp Leu Gln Glu Val Asp Gly 
225                 230                 235                 240 


Glu Ile Glu Ala Val Leu Gln Lys Lys Ala Lys Ala Arg Gly Leu Glu 
                245                 250                 255     


Phe Gln Ile Ser Asn Val Lys Phe Glu Asp Val Gly Gly Asn Asp Met 
            260                 265                 270         


Thr Leu Lys Glu Val Cys Lys Met Leu Ile His Met Arg His Pro Glu 
        275                 280                 285             


Val Tyr His His Leu Gly Val Val Pro Pro Arg Gly Val Leu Leu His 
    290                 295                 300                 


Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala His Ala Ile Ala Gly 
305                 310                 315                 320 


Glu Leu Asp Leu Pro Ile Leu Lys Val Ala Ala Pro Glu Ile Val Ser 
                325                 330                 335     


Gly Val Ser Gly Glu Ser Glu Gln Lys Leu Arg Glu Leu Phe Glu Gln 
            340                 345                 350         


Ala Val Ser Asn Ala Pro Cys Ile Ile Phe Ile Asp Glu Ile Asp Ala 
        355                 360                 365             


Ile Thr Pro Lys Arg Glu Val Ala Ser Lys Asp Met Glu Arg Arg Ile 
    370                 375                 380                 


Val Ala Gln Leu Leu Thr Cys Met Asp Asp Leu Asn Asn Val Ala Ala 
385                 390                 395                 400 


Thr Ala Arg Val Leu Val Ile Gly Ala Thr Asn Arg Pro Asp Ser Leu 
                405                 410                 415     


Asp Pro Ala Leu Arg Arg Ala Gly Arg Phe Asp Arg Glu Ile Cys Leu 
            420                 425                 430         


Gly Ile Pro Asp Glu Ala Ser Arg Glu Arg Ile Leu Gln Thr Leu Cys 
        435                 440                 445             


Arg Lys Leu Arg Leu Pro Gln Ala Phe Asp Phe Cys His Leu Ala His 
    450                 455                 460                 


Leu Thr Pro Gly Phe Val Gly Ala Asp Leu Met Ala Leu Cys Arg Glu 
465                 470                 475                 480 


Ala Ala Met Cys Ala Val Asn Arg Val Leu Met Lys Leu Gln Glu Gln 
                485                 490                 495     


Gln Lys Lys Asn Pro Glu Met Glu Asp Leu Pro Ser Lys Gly Val Gln 
            500                 505                 510         


Glu Glu Arg Leu Gly Thr Glu Pro Thr Ser Glu Thr Gln Asp Glu Leu 
        515                 520                 525             


Gln Arg Leu Leu Gly Leu Leu Arg Asp Gln Asp Pro Leu Ser Glu Glu 
    530                 535                 540                 


Gln Met Gln Gly Leu Cys Ile Glu Leu Asn Asp Phe Ile Val Ala Leu 
545                 550                 555                 560 


Ser Ser Val Gln Pro Ser Ala Lys Arg Glu Gly Phe Val Thr Val Pro 
                565                 570                 575     


Asn Val Thr Trp Ala Asp Ile Gly Ala Leu Glu Asp Ile Arg Glu Glu 
            580                 585                 590         


Leu Thr Met Ala Ile Leu Ala Pro Val Arg Asn Pro Asp Gln Phe Lys 
        595                 600                 605             


Ala Leu Gly Leu Val Thr Pro Ala Gly Val Leu Leu Ala Gly Pro Pro 
    610                 615                 620                 


Gly Cys Gly Lys Thr Leu Leu Ala Lys Ala Val Ala Asn Glu Ser Gly 
625                 630                 635                 640 


Leu Asn Phe Ile Ser Val Lys Gly Pro Glu Leu Leu Asn Met Tyr Val 
                645                 650                 655     


Gly Glu Ser Glu Arg Ala Val Arg Gln Val Phe Gln Arg Ala Lys Asn 
            660                 665                 670         


Ser Ala Pro Cys Val Ile Phe Phe Asp Glu Val Asp Ala Leu Cys Pro 
        675                 680                 685             


Arg Arg Ser Asp Arg Glu Thr Gly Ala Ser Val Arg Val Val Asn Gln 
    690                 695                 700                 


Leu Leu Thr Glu Met Asp Gly Leu Glu Ala Arg Gln Gln Val Phe Ile 
705                 710                 715                 720 


Met Ala Ala Thr Asn Arg Pro Asp Ile Ile Asp Pro Ala Ile Leu Arg 
                725                 730                 735     


Pro Gly Arg Leu Asp Lys Thr Leu Phe Val Gly Leu Pro Pro Pro Ala 
            740                 745                 750         


Asp Arg Leu Ala Ile Leu Lys Thr Ile Thr Lys Asn Gly Thr Lys Pro 
        755                 760                 765             


Pro Leu Asp Ala Asp Val Asn Leu Glu Ala Ile Ala Gly Asp Leu Arg 
    770                 775                 780                 


Cys Asp Cys Tyr Thr Gly Ala Asp Leu Ser Ala Leu Val Arg Glu Ala 
785                 790                 795                 800 


Ser Ile Cys Ala Leu Arg Gln Glu Met Ala Arg Gln Lys Ser Gly Asn 
                805                 810                 815     


Glu Lys Gly Glu Leu Lys Val Ser His Lys His Phe Glu Glu Ala Phe 
            820                 825                 830         


Lys Lys Val Arg Ser Ser Ile Ser Lys Lys Asp Gln Ile Met Tyr Glu 
        835                 840                 845             


Arg Leu Gln Glu Ser Leu Ser Arg 
    850                 855     


<210>  7303
<211>  564
<212>  DNA
<213>  Homosapiens

<400>  7303
gggcgcagat ctctctgctt tggtacgaga agcttctatc tgtgccctga gacaggaaat     60

ggcaagacag aagagtggaa atgaaaaagg caaatggatc cattcgctgt cttcatcatg    120

agtctgggct gcttatcaat tctggaaaaa cgtattcttt tgctaaggtg aactcaaggt    180

tagtcataag cattttgaag aagctttcaa gaaagtaaga tcatctatat caaaaaagga    240

tcaaatcatg tatgaacgtt tgcaggagtc cctcagccgg tgatgtctcc agcagccggc    300

ttagaggagc tagcccatca agccggcaga gaatccccca cacgctctga aggacccact    360

ttcagctgga cacaggcgcg gcctcatgta aacattttat tttcaaatga atgaggccaa    420

gctgaagctg aagctgaaga ttcttcccat ctggccagcc ttgtgtgaaa atgccttctt    480

cctctttaag aaaaaggaca atttttaaac tgctgaaata aaatgactgt tacatttttc    540

aaataaaact tttactttga acta                                           564


<210>  7304
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  7304

Met Lys Lys Ala Asn Gly Ser Ile Arg Cys Leu His His Glu Ser Gly 
1               5                   10                  15      


Leu Leu Ile Asn Ser Gly Lys Thr Tyr Ser Phe Ala Lys Val Asn Ser 
            20                  25                  30          


Arg Leu Val Ile Ser Ile Leu Lys Lys Leu Ser Arg Lys 
        35                  40                  45  


<210>  7305
<211>  583
<212>  DNA
<213>  Homosapiens

<400>  7305
taggggcgca gatctctctg ctttggtacg agaagcttct atctgtgccc tgagacagga     60

aatggcaaga cagaagagtg gaaatgaaaa agtagagacg gggtttcacc atgttagcca    120

ggatggtctc gatctcctga cttcgtgatc cgcctgcctc ggcctcccaa agtgctggga    180

ttacaggtga actcaaggtt agtcataagc attttgaaga agctttcaag aaagtaagat    240

catctatatc aaaaaaggat caaatcatgt atgaacgttt gcaggagtcc ctcagccggt    300

gatgtctcca gcagccggct tagaggagct agcccatcaa gccggcagag aatcccccac    360

acgctctgaa ggacccactt tcagctggac acaggcgcgg cctcatgtaa acattttatt    420

ttcaaatgaa tgaggccaag ctgaagctga agctgaagat tcttcccatc tggccagcct    480

tgtgtgaaaa tgccttcttc ctctttaaga aaaaggacaa tttttaaact gctgaaataa    540

aatgactgtt acatttttca aataaaactt ttactttgaa cta                      583


<210>  7306
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  7306

Met Ser Pro Ala Ala Gly Leu Glu Glu Leu Ala His Gln Ala Gly Arg 
1               5                   10                  15      


Glu Ser Pro Thr Arg Ser Glu Gly Pro Thr Phe Ser Trp Thr Gln Ala 
            20                  25                  30          


Arg Pro His Val Asn Ile Leu Phe Ser Asn Glu 
        35                  40              


<210>  7307
<211>  425
<212>  DNA
<213>  Homosapiens

<400>  7307
cacactgagt cacagtcctt agagatttca gtacggagta ccagaaacag ttgttattag     60

gagtgctatt gtataacaat ttgaagctta gtgaagcata acataaacaa taaatatata    120

acctttttga agcagatagc aactgctatt tttatttatt tttattttta tttttttcga    180

gacggagttt tgctcttgtc tcccaggctg gagtgcaatg gtgcatctcg gctcactgca    240

acttccgcct cctgggttca agcgattctc ctccctcagc ctcttgggag gcagaggcag    300

gagaattgct tgaacctggg agatggaggt tgcagtgagc caagatcaca ccattgtact    360

ccattctggg caacaagagt gaaacttcat ctcaaaaaac aaaacaaaca aacaaacaaa    420

aaagc                                                                425


<210>  7308
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  7308

Met Val His Leu Gly Ser Leu Gln Leu Pro Pro Pro Gly Phe Lys Arg 
1               5                   10                  15      


Phe Ser Ser Leu Ser Leu Leu Gly Gly Arg Gly Arg Arg Ile Ala 
            20                  25                  30      


<210>  7309
<211>  725
<212>  DNA
<213>  Homosapiens

<400>  7309
gactaggagc tggcggtccg agctgtggct tggaagaccg acgcgatgaa gcccagacct     60

gcagggttcg tggataataa actcaagcag cgagtcatcc agtaccttac cagtaacaaa    120

tgtggcaaat atgtggacat tggagtctta gcgtctgatt tacaaagagt gtacagtata    180

gactatggtc gaagaaaaag aaatgctttt aggattcagg tagaaaaagt atttagcata    240

attagtagtg agaaggaact taagaattta acagaattag aagatgaaca tttggcaaaa    300

agggcaagac aaggtgaaga ggataatgag tatactgaaa gctattctga tgatgattca    360

agtatggaag actacccaga tccacagtca gcaaatcaca tgaacagttc cctgctgtct    420

ttatatcgga aaggaaatcc tgattctgtt tcaaatactc ctgagatgga gcaaagagaa    480

accacctctt caacaccacg gataagttcc aaaacaggct ccattccctt gaagacccct    540

gccaaagatt ctgaaggagg atggtttatt gacaaaaccc caagtgtaaa gaaagacagt    600

tttttcttgg acctgtcatg tgagaaaagt aatcctaaga agccaataac tgagatacag    660

gattcaaaag attcttctct tttggagagt gatatgaaac ggaaaggcaa gctaaagaat    720

aaagg                                                                725


<210>  7310
<211>  225
<212>  PRT
<213>  Homosapiens

<400>  7310

Met Lys Pro Arg Pro Ala Gly Phe Val Asp Asn Lys Leu Lys Gln Arg 
1               5                   10                  15      


Val Ile Gln Tyr Leu Thr Ser Asn Lys Cys Gly Lys Tyr Val Asp Ile 
            20                  25                  30          


Gly Val Leu Ala Ser Asp Leu Gln Arg Val Tyr Ser Ile Asp Tyr Gly 
        35                  40                  45              


Arg Arg Lys Arg Asn Ala Phe Arg Ile Gln Val Glu Lys Val Phe Ser 
    50                  55                  60                  


Ile Ile Ser Ser Glu Lys Glu Leu Lys Asn Leu Thr Glu Leu Glu Asp 
65                  70                  75                  80  


Glu His Leu Ala Lys Arg Ala Arg Gln Gly Glu Glu Asp Asn Glu Tyr 
                85                  90                  95      


Thr Glu Ser Tyr Ser Asp Asp Asp Ser Ser Met Glu Asp Tyr Pro Asp 
            100                 105                 110         


Pro Gln Ser Ala Asn His Met Asn Ser Ser Leu Leu Ser Leu Tyr Arg 
        115                 120                 125             


Lys Gly Asn Pro Asp Ser Val Ser Asn Thr Pro Glu Met Glu Gln Arg 
    130                 135                 140                 


Glu Thr Thr Ser Ser Thr Pro Arg Ile Ser Ser Lys Thr Gly Ser Ile 
145                 150                 155                 160 


Pro Leu Lys Thr Pro Ala Lys Asp Ser Glu Gly Gly Trp Phe Ile Asp 
                165                 170                 175     


Lys Thr Pro Ser Val Lys Lys Asp Ser Phe Phe Leu Asp Leu Ser Cys 
            180                 185                 190         


Glu Lys Ser Asn Pro Lys Lys Pro Ile Thr Glu Ile Gln Asp Ser Lys 
        195                 200                 205             


Asp Ser Ser Leu Leu Glu Ser Asp Met Lys Arg Lys Gly Lys Leu Lys 
    210                 215                 220                 


Asn 
225 


<210>  7311
<211>  664
<212>  DNA
<213>  Homosapiens

<400>  7311
gcaagggcct atcaggggtg ggtcggggca tccgagcggg tttgacggaa ggagcggcgg     60

cgacggagga ggaggatgga ggcggtggtg ttcgtcttct ctctcctcga ttgttgcgcg    120

ctcatcttcc tctcggtcta cttcataatt acattgtctg atttagaatg tgattacatt    180

aatgctagat catgttgctc aaaattaaac aagtgggtaa ttccagaatt gattggccat    240

accattgtca ctgtattact gctcatgtca ttgcactggt tcatcttcct tctcaactta    300

cctgttgcca cttggaatat atatcgatac attatggtgc cgagtggtaa catgggagtg    360

tttgatccaa cagaaataca caatcgaggg cagctgaagt cacacatgaa agaagccatg    420

atcaagcttg gtttccactt gctctgcttc ttcatgtatc tttatagtat gatcttagct    480

ttgataaatg actgaagctg gagaagccgt ggttgaagtc agcctacact acagtgcaca    540

gttgaggagc cagagacttc ttaaatcatc cttagaaccg tgaccatagc agtatatatt    600

ttcctcttgg aacaaaaaac tatttttgct gtatttttac catataaagt atttaaaaaa    660

catg                                                                 664


<210>  7312
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  7312

Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu 
1               5                   10                  15      


Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys 
            20                  25                  30          


Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val 
        35                  40                  45              


Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met 
    50                  55                  60                  


Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp 
65                  70                  75                  80  


Asn Ile Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Met Gly Val Phe 
                85                  90                  95      


Asp Pro Thr Glu Ile His Asn Arg Gly Gln Leu Lys Ser His Met Lys 
            100                 105                 110         


Glu Ala Met Ile Lys Leu Gly Phe His Leu Leu Cys Phe Phe Met Tyr 
        115                 120                 125             


Leu Tyr Ser Met Ile Leu Ala Leu Ile Asn Asp 
    130                 135                 


<210>  7313
<211>  701
<212>  DNA
<213>  Homosapiens

<400>  7313
ctatcagggg tgggtcgggg catccgagcg ggtttgacgg aaggagcggc ggcgacggag     60

gaggaggatg gaggcggtgg tgttcgtctt ctctctcctc gattgttgcg cgctcatctt    120

cctctcggtc tacttcataa ttacattgtc tgatttagaa tgtgattaca ttaatgctag    180

atcatgttgc tcaaaattaa acaagtgggt aattccagaa ttgattggcc ataccattgt    240

cactgtatta ctgctcatgt cattgcactg gttcatcttc cttctcaact tacctgttgc    300

cacttggaat atatatcgtg gtagcaactg cccttgctaa tcaccgtaac ctcggctgag    360

aaagaagagg aagcgaaatc caagatgcag ctcagttcat caaagcctag caggtcccct    420

cagctgcctt ttcatgcctg ccacagacta cagtaggaca aaacctgacc tggtctttga    480

agttaagagc taagaaagct tcctatagta gtatctccca tggcacttac cacattctat    540

ctggtattac agttatttgt atgcaattaa tcactcttag attgtatgtt cctggagggc    600

agaatatgcc cattcatatt tgtatcttct tccttctgct cttggcacct aacacagtgc    660

cttgcacaca aacaataaat gattgttgag tgaataagta a                        701


<210>  7314
<211>  90
<212>  PRT
<213>  Homosapiens

<400>  7314

Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu 
1               5                   10                  15      


Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys 
            20                  25                  30          


Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val 
        35                  40                  45              


Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met 
    50                  55                  60                  


Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp 
65                  70                  75                  80  


Asn Ile Tyr Arg Gly Ser Asn Cys Pro Cys 
                85                  90  


<210>  7315
<211>  502
<212>  DNA
<213>  Homosapiens

<400>  7315
gtcggggcat ccgagcgggt ttgacggaag gagcggcggc gacggaggag gaggatggag     60

gcggtggtgt tcgtcttctc tctcctcgat tgttgcgcgc tcatcttcct ctcggtctac    120

ttcataatta cattgtctga tttagaatgt gattacatta atgctagatc atgttgctca    180

aaattaaaca agtgggtaat tccagaattg attggccata ccattgtcac tgtattactg    240

ctcatgtcat tgcactggtt catcttcctt ctcaacttac ctgttgccac ttggaatata    300

tatcgtatga tcttagcttt gataaatgac tgaagctgga gaagccgtgg ttgaagtcag    360

cctacactac agtgcacagt tgaggagcca gagacttctt aaatcatcct tagaaccgtg    420

accatagcag tatatatttt cctcttggaa caaaaaacta tttttgctgt atttttacca    480

tataaagtat ttaaaaaaca tg                                             502


<210>  7316
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  7316

Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu 
1               5                   10                  15      


Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys 
            20                  25                  30          


Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val 
        35                  40                  45              


Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met 
    50                  55                  60                  


Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp 
65                  70                  75                  80  


Asn Ile Tyr Arg Met Ile Leu Ala Leu Ile Asn Asp 
                85                  90          


<210>  7317
<211>  1525
<212>  DNA
<213>  Homosapiens

<400>  7317
ccgagcgggt ttgacggaag gagcggcggc gacggaggag gaggatggag gcggtggtgt     60

tcgtcttctc tctcctcgat tgttgcgcgc tcatcttcct ctcggtctac ttcataatta    120

cattgtctga tttagaatgt gattacatta atgctagatc atgttgctca aaattaaaca    180

agtgggtaat tccagaattg attggccata ccattgtcac tgtattactg ctcatgtcat    240

tgcactggtt catcttcctt ctcaacttac ctgttgccac ttggaatata tatcgataca    300

ttatggtgcc gagtggtaac atgggagtgt ttgatccaac agaaatacac aatcgagggc    360

agctgaagtc acacatgaaa gaagccatga tcaagcttgg tttccacttg ctctgcttct    420

tcatgtatct ttatagtatg atcttagctt tgataaatga ctgaagctgg agaagccgtg    480

gttgaagtca gcctacacta cagtgcacag ttgaggagcc agagacttct taaatcatcc    540

ttagaaccgt gaccatagca gtatatattt tcctcttgga acaaaaaact atttttgctg    600

tatttttacc atataaagta tttaaaaaac atgaattgag tttctgtaga tttctagttc    660

tcaactttag cctgaacgcc aacacttgaa ggtgtttttc atcctctgta tgttgaaggt    720

ggttatttgt atgtaggaac aggactgcca tcccagcttt gcatgccaaa gaaataaaga    780

acacacttta aagggcaaac tgaagagatg agcgagcaaa ggtgcccttc aggtctactg    840

aaaagttaga gtacaaaaca acactgttga tctggacaaa agaagaaaaa ttaccctttt    900

tgcttgtgtt gtgacaactt catttaatat ggtttaaaga tttatgagac tgtcagctaa    960

aagtcttttc acaagaatgt caacagagaa tggcatctca aaatatatat atttctttgc   1020

acaatttgtg aaaccttata agccattttc cccaggtaca atgtagttcc tgctgataga   1080

aaggaaatat tttgtcaaga gctttcattt aaaagctact acctccacaa tcacccccaa   1140

acccagaaaa tccccactgg ctcttgccag tctggttttc gtattgcagt tattccaatt   1200

gtatttgatc tccctgataa cgtattttca tgggtttggg tagaagatgc taatcagatt   1260

agaagcagga atagttattt gctgtctgtg aaattgagcc ttttggtgcg ccacgtggtg   1320

ccagatcaac acttctatcc ctctgcactg accacgttgt gaactgggag accaaatgca   1380

agccatttca tggacatagc aatatacaac caaactctgt tccttggagt tatattgtaa   1440

actcttgcag gtgggagagc agttcacctc cttagctctg tttgccagct cttacagggt   1500

aaaataaacc tggcaattta tcctc                                         1525


<210>  7318
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  7318

Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu 
1               5                   10                  15      


Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys 
            20                  25                  30          


Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val 
        35                  40                  45              


Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met 
    50                  55                  60                  


Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp 
65                  70                  75                  80  


Asn Ile Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Met Gly Val Phe 
                85                  90                  95      


Asp Pro Thr Glu Ile His Asn Arg Gly Gln Leu Lys Ser His Met Lys 
            100                 105                 110         


Glu Ala Met Ile Lys Leu Gly Phe His Leu Leu Cys Phe Phe Met Tyr 
        115                 120                 125             


Leu Tyr Ser Met Ile Leu Ala Leu Ile Asn Asp 
    130                 135                 


<210>  7319
<211>  2124
<212>  DNA
<213>  Homosapiens

<400>  7319
ccgagcgggt ttgacggaag gagcggcggc gacggaggag gaggatggag gcggtggtgt     60

tcgtcttctc tctcctcgat tgttgcgcgc tcatcttcct ctcggtctac ttcataatta    120

cattgtctga tttagaatgt gattacatta atgctagatc atgttgctca aaattaaaca    180

agtgggtaat tccagaattg attggccata ccattgtcac tgtattactg ctcatgtcat    240

tgcactggtt catcttcctt ctcaacttac ctgttgccac ttggaatata tatcgataca    300

ttatggtgcc gagtggtaac atgggagtgt ttgatccaac agaaatacac aatcgagggc    360

agctgaagtc acacatgaaa gaagccatga tcaagcttgg tttccacttg ctctgcttct    420

tcatgtatct ttatagtatg atcttagctt tgataaatga ctgaagctgg agaagccgtg    480

gttgaagtca gcctacacta cagtgcacag ttgaggagcc agagacttct taaatcatcc    540

ttagaaccgt gaccatagca gtatatattt tcctcttgga acaaaaaact atttttgctg    600

tatttttacc atataaagta tttaaaaaac atgaattgag tttctgtaga tttctagttc    660

tcaactttag cctgaacgcc aacacttgaa ggtgtttttc atcctctgta tgttgaaggt    720

ggttatttgt atgtaggaac aggactgcca tcccagcttt gcatgccaaa gaaataaaga    780

acacacttta aagggcaaac tgaagagatg agcgagcaaa ggtgcccttc aggtctactg    840

aaaagttaga gtacaaaaca acactgttga tctggacaaa agaagaaaaa ttaccctttt    900

tgcttgtgtt gtgacaactt catttaatat ggtttaaaga tttatgagac tgtcagctaa    960

aagtcttttc acaagaatgt caacagagaa tggcatctca aaatatatat atttctttgc   1020

acaatttgtg aaaccttata agccattttc cccaggtaca atgtagttcc tgctgataga   1080

aaggaaatat tttgtcaaga gctttcattt aaaagctact acctccacaa tcacccccaa   1140

acccagaaaa tccccactgg ctcttgccag tctggttttc gtattgcagt tattccaatt   1200

gtatttgatc tccctgataa cgtattttca tgggtttggg tagaagatgc taatcagatt   1260

agaagcagga atagttattt gctgtctgtg aaattgagcc ttttggtgcg ccacgtggtg   1320

ccagatcaac acttctatcc ctctgcactg accacgttgt gaactgggag accaaatgca   1380

agccatttca tggacatagc aatatacaac caaactctgt tccttggagt tatattgtaa   1440

actcttgcag gtgggagagc agttcacctc cttagctctg tttgccagct cttacagggt   1500

aaaataaacc tggcaattta tcctcagtcc tagtttgtgg tttaatgttg ctatcttaag   1560

cactggcatt tgggcaaaac atgactgtgt tctgtgggag aatccaaagg cattattcac   1620

tctagttgag atagaattgg gtggctaaac agggtgtgtg gtacccaaaa gattaaatgt   1680

tacatgtcct tttagtcctt gaccaggtct agccttggca gaagcaaggg agccactaag   1740

ccaaactccc tgtgcagaca gaccatgttt caaggctgga agtagtgccc tggcaacaca   1800

caaaaggaac ggtgaaatgg taggcaaagt gaacttggct ctgctggcct ctttggggtc   1860

acagaaattg ctccttgtgg taatcttata tttctgtcag gcacagggcc aagaagctgt   1920

gtaacagaca ttactttgct tgcatctctt tttcatacct tttccctctg aggcagcttt   1980

tgcttagaaa acagtccctt cactctgcct ttcctcctaa cttcctgtgc ctcttcatgt   2040

tctgctcaag ctttttaaag caacgaagct gttggagaac ttaaatcctt gcaactgaga   2100

gataagctac ttaaaggcgg taga                                          2124


<210>  7320
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  7320

Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu 
1               5                   10                  15      


Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys 
            20                  25                  30          


Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val 
        35                  40                  45              


Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met 
    50                  55                  60                  


Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp 
65                  70                  75                  80  


Asn Ile Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Met Gly Val Phe 
                85                  90                  95      


Asp Pro Thr Glu Ile His Asn Arg Gly Gln Leu Lys Ser His Met Lys 
            100                 105                 110         


Glu Ala Met Ile Lys Leu Gly Phe His Leu Leu Cys Phe Phe Met Tyr 
        115                 120                 125             


Leu Tyr Ser Met Ile Leu Ala Leu Ile Asn Asp 
    130                 135                 


<210>  7321
<211>  819
<212>  DNA
<213>  Homosapiens

<400>  7321
ccgagcgggt ttgacggaag gagcggcggc gacggaggag gaggatggag gcggtggtgt     60

tcgtcttctc tctcctcgat tgttgcgcgc tcatcttcct ctcggtctac ttcataatta    120

cattgtctga tttagaatgt gattacatta atgctagatc atgttgctca aaattaaaca    180

agtgggtaat tccagaattg attggccata ccattgtcac tgtattactg ctcatgtcat    240

tgcactggtt catcttcctt ctcaacttac ctgttgccac ttggaatata tatcgataca    300

ttatggtgcc gagtggtaac atgggagtgt ttgatccaac agaaatacac aatcgagggc    360

agctgaagtc acacatgaaa gaagccatga tcaagcttgg tttccacttg ctctgcttct    420

tcatgtatct ttatagtggt agcaactgcc cttgctaatc accgtaacct cggctgagaa    480

agaagaggaa gcgaaatcca agatgcagct cagttcatca aagcctagca ggtcccctca    540

gctgcctttt catgcctgcc acagactaca gtaggacaaa acctgacctg gtctttgaag    600

ttaagagcta agaaagcttc ctatagtagt atctcccatg gcacttacca cattctatct    660

ggtattacag ttatttgtat gcaattaatc actcttagat tgtatgttcc tggagggcag    720

aatatgccca ttcatatttg tatcttcttc cttctgctct tggcacctaa cacagtgcct    780

tgcacacaaa caataaatga ttgttgagtg aataagtaa                           819


<210>  7322
<211>  137
<212>  PRT
<213>  Homosapiens

<400>  7322

Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu 
1               5                   10                  15      


Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys 
            20                  25                  30          


Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val 
        35                  40                  45              


Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met 
    50                  55                  60                  


Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp 
65                  70                  75                  80  


Asn Ile Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Met Gly Val Phe 
                85                  90                  95      


Asp Pro Thr Glu Ile His Asn Arg Gly Gln Leu Lys Ser His Met Lys 
            100                 105                 110         


Glu Ala Met Ile Lys Leu Gly Phe His Leu Leu Cys Phe Phe Met Tyr 
        115                 120                 125             


Leu Tyr Ser Gly Ser Asn Cys Pro Cys 
    130                 135         


<210>  7323
<211>  905
<212>  DNA
<213>  Homosapiens

<400>  7323
gggtttgacg gaaggagcgg cggcgacgga ggaggaggat ggaggcggtg gtgttcgtct     60

tctctctcct cgattgttgc gcgctcatct tcctctcggt ctacttcgcc agttgcagtg    120

gctgacacct gtccccagta ctttgggagg ccgaggaggg agaatcactt gagcccagcg    180

gttcgagacc agctctggta acatagggag acttcctctc tacaaaaata aaacaagagg    240

aaaaaaaaaa gaaacatgtt tcaggtctgt gtctgtgtaa tacaaagatg actgcagcct    300

acagtaagaa atccagagac tgaaggctat agctttaggg atctgatatg gatcgcagag    360

tattagtata acatcagctg acattttatt gagtgcctac tttgcatgtg gcttacatgt    420

tatttcatct aattctctac aacaacttcg tgagtgggta attccagaat tgattggcca    480

taccattgtc actgtattac tgctcatgtc attgcactgg ttcatcttcc ttctcaactt    540

acctgttgcc acttggaata tatatcgata cattatggtg ccgagtggta acatgggagt    600

gtttgatcca acagaaatac acaatcgagg gcagctgaag tcacacatga aagaagccat    660

gatcaagctt ggtttccact tgctctgctt cttcatgtat ctttatagta tgatcttagc    720

tttgataaat gactgaagct ggagaagccg tggttgaagt cagcctacac tacagtgcac    780

agttgaggag ccagagactt cttaaatcat ccttagaacc gtgaccatag cagtatatat    840

tttcctcttg gaacaaaaaa ctatttttgc tgtattttta ccatataaag tatttaaaaa    900

acatg                                                                905


<210>  7324
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  7324

Met Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr 
1               5                   10                  15      


Trp Asn Ile Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Met Gly Val 
            20                  25                  30          


Phe Asp Pro Thr Glu Ile His Asn Arg Gly Gln Leu Lys Ser His Met 
        35                  40                  45              


Lys Glu Ala Met Ile Lys Leu Gly Phe His Leu Leu Cys Phe Phe Met 
    50                  55                  60                  


Tyr Leu Tyr Ser Met Ile Leu Ala Leu Ile Asn Asp 
65                  70                  75      


<210>  7325
<211>  1797
<212>  DNA
<213>  Homosapiens

<400>  7325
gggtttgacg gaaggagcgg cggcgacgga ggaggaggat ggaggcggtg gtgttcgtct     60

tctctctcct cgattgttgc gcgctcatct tcctctcggt ctacttcgcc agttgcagtg    120

gctgacacct gtccccagta ctttgggagg ccgaggaggg agaatcactt gagcccagcg    180

gttcgagacc agctctggta acatagggag acttcctctc tacaaaaata aaacaagagg    240

aaaaaaaaaa gaaacatgtt tcaggtctgt gtctgtgtaa tacaaagatg actgcagcct    300

acagtaagaa atccagagac tgaaggctat agctttaggg atctgatatg gatcgcagag    360

tattagtata acatcagctg acattttatt gagtgcctac tttgcatgtg gcttacatgt    420

tatttcatct aattctctac aacaacttcg tgagtgggta attccagaat tgattggcca    480

taccattgtc actgtattac tgctcatgtc attgcactgg ttcatcttcc ttctcaactt    540

acctgttgcc acttggaata tatatcgata cattatggtg ccgagtggta acatgggagt    600

gtttgatcca acagaaatac acaatcgagg gcagctgaag tcacacatga aagaagccat    660

gatcaagctt ggtttccact tgctctgctt cttcatgtat ctttatagta tgatcttagc    720

tttgataaat gactgaagct ggagaagccg tggttgaagt cagcctacac tacagtgcac    780

agttgaggag ccagagactt cttaaatcat ccttagaacc gtgaccatag cagtatatat    840

tttcctcttg gaacaaaaaa ctatttttgc tgtattttta ccatataaag tatttaaaaa    900

acatgaattg agtttctgta gatttctagt tctcaacttt agcctgaacg ccaacacttg    960

aaggtgtttt tcatcctctg tatgttgaag gtggttattt gtatgtagga acaggactgc   1020

catcccagct ttgcatgcca aagaaataaa gaacacactt taaagggcaa actgaagaga   1080

tgagcgagca aaggtgccct tcaggtctac tgaaaagtta gagtacaaaa caacactgtt   1140

gatctggaca aaagaagaaa aattaccctt tttgcttgtg ttgtgacaac ttcatttaat   1200

atggtttaaa gatttatgag actgtcagct aaaagtcttt tcacaagaat gtcaacagag   1260

aatggcatct caaaatatat atatttcttt gcacaatttg tgaaacctta taagccattt   1320

tccccaggta caatgtagtt cctgctgata gaaaggaaat attttgtcaa gagctttcat   1380

ttaaaagcta ctacctccac aatcaccccc aaacccagaa aatccccact ggctcttgcc   1440

agtctggttt tcgtattgca gttattccaa ttgtatttga tctccctgat aacgtatttt   1500

catgggtttg ggtagaagat gctaatcaga ttagaagcag gaatagttat ttgctgtctg   1560

tgaaattgag ccttttggtg cgccacgtgg tgccagatca acacttctat ccctctgcac   1620

tgaccacgtt gtgaactggg agaccaaatg caagccattt catggacata gcaatataca   1680

accaaactct gttccttgga gttatattgt aaactcttgc aggtgggaga gcagttcacc   1740

tccttagctc tgtttgccag ctcttacagg gtaaaataaa cctggcaatt tatcctc      1797


<210>  7326
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  7326

Met Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr 
1               5                   10                  15      


Trp Asn Ile Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Met Gly Val 
            20                  25                  30          


Phe Asp Pro Thr Glu Ile His Asn Arg Gly Gln Leu Lys Ser His Met 
        35                  40                  45              


Lys Glu Ala Met Ile Lys Leu Gly Phe His Leu Leu Cys Phe Phe Met 
    50                  55                  60                  


Tyr Leu Tyr Ser Met Ile Leu Ala Leu Ile Asn Asp 
65                  70                  75      


<210>  7327
<211>  2396
<212>  DNA
<213>  Homosapiens

<400>  7327
gggtttgacg gaaggagcgg cggcgacgga ggaggaggat ggaggcggtg gtgttcgtct     60

tctctctcct cgattgttgc gcgctcatct tcctctcggt ctacttcgcc agttgcagtg    120

gctgacacct gtccccagta ctttgggagg ccgaggaggg agaatcactt gagcccagcg    180

gttcgagacc agctctggta acatagggag acttcctctc tacaaaaata aaacaagagg    240

aaaaaaaaaa gaaacatgtt tcaggtctgt gtctgtgtaa tacaaagatg actgcagcct    300

acagtaagaa atccagagac tgaaggctat agctttaggg atctgatatg gatcgcagag    360

tattagtata acatcagctg acattttatt gagtgcctac tttgcatgtg gcttacatgt    420

tatttcatct aattctctac aacaacttcg tgagtgggta attccagaat tgattggcca    480

taccattgtc actgtattac tgctcatgtc attgcactgg ttcatcttcc ttctcaactt    540

acctgttgcc acttggaata tatatcgata cattatggtg ccgagtggta acatgggagt    600

gtttgatcca acagaaatac acaatcgagg gcagctgaag tcacacatga aagaagccat    660

gatcaagctt ggtttccact tgctctgctt cttcatgtat ctttatagta tgatcttagc    720

tttgataaat gactgaagct ggagaagccg tggttgaagt cagcctacac tacagtgcac    780

agttgaggag ccagagactt cttaaatcat ccttagaacc gtgaccatag cagtatatat    840

tttcctcttg gaacaaaaaa ctatttttgc tgtattttta ccatataaag tatttaaaaa    900

acatgaattg agtttctgta gatttctagt tctcaacttt agcctgaacg ccaacacttg    960

aaggtgtttt tcatcctctg tatgttgaag gtggttattt gtatgtagga acaggactgc   1020

catcccagct ttgcatgcca aagaaataaa gaacacactt taaagggcaa actgaagaga   1080

tgagcgagca aaggtgccct tcaggtctac tgaaaagtta gagtacaaaa caacactgtt   1140

gatctggaca aaagaagaaa aattaccctt tttgcttgtg ttgtgacaac ttcatttaat   1200

atggtttaaa gatttatgag actgtcagct aaaagtcttt tcacaagaat gtcaacagag   1260

aatggcatct caaaatatat atatttcttt gcacaatttg tgaaacctta taagccattt   1320

tccccaggta caatgtagtt cctgctgata gaaaggaaat attttgtcaa gagctttcat   1380

ttaaaagcta ctacctccac aatcaccccc aaacccagaa aatccccact ggctcttgcc   1440

agtctggttt tcgtattgca gttattccaa ttgtatttga tctccctgat aacgtatttt   1500

catgggtttg ggtagaagat gctaatcaga ttagaagcag gaatagttat ttgctgtctg   1560

tgaaattgag ccttttggtg cgccacgtgg tgccagatca acacttctat ccctctgcac   1620

tgaccacgtt gtgaactggg agaccaaatg caagccattt catggacata gcaatataca   1680

accaaactct gttccttgga gttatattgt aaactcttgc aggtgggaga gcagttcacc   1740

tccttagctc tgtttgccag ctcttacagg gtaaaataaa cctggcaatt tatcctcagt   1800

cctagtttgt ggtttaatgt tgctatctta agcactggca tttgggcaaa acatgactgt   1860

gttctgtggg agaatccaaa ggcattattc actctagttg agatagaatt gggtggctaa   1920

acagggtgtg tggtacccaa aagattaaat gttacatgtc cttttagtcc ttgaccaggt   1980

ctagccttgg cagaagcaag ggagccacta agccaaactc cctgtgcaga cagaccatgt   2040

ttcaaggctg gaagtagtgc cctggcaaca cacaaaagga acggtgaaat ggtaggcaaa   2100

gtgaacttgg ctctgctggc ctctttgggg tcacagaaat tgctccttgt ggtaatctta   2160

tatttctgtc aggcacaggg ccaagaagct gtgtaacaga cattactttg cttgcatctc   2220

tttttcatac cttttccctc tgaggcagct tttgcttaga aaacagtccc ttcactctgc   2280

ctttcctcct aacttcctgt gcctcttcat gttctgctca agctttttaa agcaacgaag   2340

ctgttggaga acttaaatcc ttgcaactga gagataagct acttaaaggc ggtaga       2396


<210>  7328
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  7328

Met Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr 
1               5                   10                  15      


Trp Asn Ile Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Met Gly Val 
            20                  25                  30          


Phe Asp Pro Thr Glu Ile His Asn Arg Gly Gln Leu Lys Ser His Met 
        35                  40                  45              


Lys Glu Ala Met Ile Lys Leu Gly Phe His Leu Leu Cys Phe Phe Met 
    50                  55                  60                  


Tyr Leu Tyr Ser Met Ile Leu Ala Leu Ile Asn Asp 
65                  70                  75      


<210>  7329
<211>  1524
<212>  DNA
<213>  Homosapiens

<400>  7329
ggtttgacgg aaggagcggc ggcgacggag gaggaggatg gaggcggtgg tgttcgtctt     60

ctctctcctc gattgttgcg cgctcatctt cctctcggtc tacttcgtat ccttgcctga    120

ggcaggcgaa cgccttgccg ggggacacgg ctgagggtgg gccagttggg cacccgggca    180

gtgggtaatt ccagaattga ttggccatac cattgtcact gtattactgc tcatgtcatt    240

gcactggttc atcttccttc tcaacttacc tgttgccact tggaatatat atcgatacat    300

tatggtgccg agtggtaaca tgggagtgtt tgatccaaca gaaatacaca atcgagggca    360

gctgaagtca cacatgaaag aagccatgat caagcttggt ttccacttgc tctgcttctt    420

catgtatctt tatagtatga tcttagcttt gataaatgac tgaagctgga gaagccgtgg    480

ttgaagtcag cctacactac agtgcacagt tgaggagcca gagacttctt aaatcatcct    540

tagaaccgtg accatagcag tatatatttt cctcttggaa caaaaaacta tttttgctgt    600

atttttacca tataaagtat ttaaaaaaca tgaattgagt ttctgtagat ttctagttct    660

caactttagc ctgaacgcca acacttgaag gtgtttttca tcctctgtat gttgaaggtg    720

gttatttgta tgtaggaaca ggactgccat cccagctttg catgccaaag aaataaagaa    780

cacactttaa agggcaaact gaagagatga gcgagcaaag gtgcccttca ggtctactga    840

aaagttagag tacaaaacaa cactgttgat ctggacaaaa gaagaaaaat tacccttttt    900

gcttgtgttg tgacaacttc atttaatatg gtttaaagat ttatgagact gtcagctaaa    960

agtcttttca caagaatgtc aacagagaat ggcatctcaa aatatatata tttctttgca   1020

caatttgtga aaccttataa gccattttcc ccaggtacaa tgtagttcct gctgatagaa   1080

aggaaatatt ttgtcaagag ctttcattta aaagctacta cctccacaat cacccccaaa   1140

cccagaaaat ccccactggc tcttgccagt ctggttttcg tattgcagtt attccaattg   1200

tatttgatct ccctgataac gtattttcat gggtttgggt agaagatgct aatcagatta   1260

gaagcaggaa tagttatttg ctgtctgtga aattgagcct tttggtgcgc cacgtggtgc   1320

cagatcaaca cttctatccc tctgcactga ccacgttgtg aactgggaga ccaaatgcaa   1380

gccatttcat ggacatagca atatacaacc aaactctgtt ccttggagtt atattgtaaa   1440

ctcttgcagg tgggagagca gttcacctcc ttagctctgt ttgccagctc ttacagggta   1500

aaataaacct ggcaatttat cctc                                          1524


<210>  7330
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  7330

Met Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr 
1               5                   10                  15      


Trp Asn Ile Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Met Gly Val 
            20                  25                  30          


Phe Asp Pro Thr Glu Ile His Asn Arg Gly Gln Leu Lys Ser His Met 
        35                  40                  45              


Lys Glu Ala Met Ile Lys Leu Gly Phe His Leu Leu Cys Phe Phe Met 
    50                  55                  60                  


Tyr Leu Tyr Ser Met Ile Leu Ala Leu Ile Asn Asp 
65                  70                  75      


<210>  7331
<211>  567
<212>  DNA
<213>  Homosapiens

<400>  7331
acggaaggag cggcggcgac ggaggaggag gatggaggcg gtggtgttcg tcttctctct     60

cctcgattgt tgcgcgctca tcttcctctc ggtctacttc ataattacat tgtctgattt    120

agaatgtgat tacattaatg ctagatcatg ttgctcaaat actgctcatg tcattgcact    180

ggttcatctt ccttctcaac ttacctgttg ccacttggaa tatatatcga tacattatgg    240

tgccgagtgg taacatggga gtgtttgatc caacagaaat acacaatcga gggcagctga    300

agtcacacat gaaagaagcc atgatcaagc ttggtttcca cttgctctgc ttcttcatgt    360

atctttatag tatgatctta gctttgataa atgactgaag ctggagaagc cgtggttgaa    420

gtcagcctac actacagtgc acagttgagg agccagagac ttcttaaatc atccttagaa    480

ccgtgaccat agcagtatat attttcctct tggaacaaaa aactattttt gctgtatttt    540

taccatataa agtatttaaa aaacatg                                        567


<210>  7332
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  7332

Met Leu Asp His Val Ala Gln Ile Leu Leu Met Ser Leu His Trp Phe 
1               5                   10                  15      


Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp Asn Ile Tyr Arg Tyr 
            20                  25                  30          


Ile Met Val Pro Ser Gly Asn Met Gly Val Phe Asp Pro Thr Glu Ile 
        35                  40                  45              


His Asn Arg Gly Gln Leu Lys Ser His Met Lys Glu Ala Met Ile Lys 
    50                  55                  60                  


Leu Gly Phe His Leu Leu Cys Phe Phe Met Tyr Leu Tyr Ser Met Ile 
65                  70                  75                  80  


Leu Ala Leu Ile Asn Asp 
                85      


<210>  7333
<211>  1459
<212>  DNA
<213>  Homosapiens

<400>  7333
acggaaggag cggcggcgac ggaggaggag gatggaggcg gtggtgttcg tcttctctct     60

cctcgattgt tgcgcgctca tcttcctctc ggtctacttc ataattacat tgtctgattt    120

agaatgtgat tacattaatg ctagatcatg ttgctcaaat actgctcatg tcattgcact    180

ggttcatctt ccttctcaac ttacctgttg ccacttggaa tatatatcga tacattatgg    240

tgccgagtgg taacatggga gtgtttgatc caacagaaat acacaatcga gggcagctga    300

agtcacacat gaaagaagcc atgatcaagc ttggtttcca cttgctctgc ttcttcatgt    360

atctttatag tatgatctta gctttgataa atgactgaag ctggagaagc cgtggttgaa    420

gtcagcctac actacagtgc acagttgagg agccagagac ttcttaaatc atccttagaa    480

ccgtgaccat agcagtatat attttcctct tggaacaaaa aactattttt gctgtatttt    540

taccatataa agtatttaaa aaacatgaat tgagtttctg tagatttcta gttctcaact    600

ttagcctgaa cgccaacact tgaaggtgtt tttcatcctc tgtatgttga aggtggttat    660

ttgtatgtag gaacaggact gccatcccag ctttgcatgc caaagaaata aagaacacac    720

tttaaagggc aaactgaaga gatgagcgag caaaggtgcc cttcaggtct actgaaaagt    780

tagagtacaa aacaacactg ttgatctgga caaaagaaga aaaattaccc tttttgcttg    840

tgttgtgaca acttcattta atatggttta aagatttatg agactgtcag ctaaaagtct    900

tttcacaaga atgtcaacag agaatggcat ctcaaaatat atatatttct ttgcacaatt    960

tgtgaaacct tataagccat tttccccagg tacaatgtag ttcctgctga tagaaaggaa   1020

atattttgtc aagagctttc atttaaaagc tactacctcc acaatcaccc ccaaacccag   1080

aaaatcccca ctggctcttg ccagtctggt tttcgtattg cagttattcc aattgtattt   1140

gatctccctg ataacgtatt ttcatgggtt tgggtagaag atgctaatca gattagaagc   1200

aggaatagtt atttgctgtc tgtgaaattg agccttttgg tgcgccacgt ggtgccagat   1260

caacacttct atccctctgc actgaccacg ttgtgaactg ggagaccaaa tgcaagccat   1320

ttcatggaca tagcaatata caaccaaact ctgttccttg gagttatatt gtaaactctt   1380

gcaggtggga gagcagttca cctccttagc tctgtttgcc agctcttaca gggtaaaata   1440

aacctggcaa tttatcctc                                                1459


<210>  7334
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  7334

Met Leu Asp His Val Ala Gln Ile Leu Leu Met Ser Leu His Trp Phe 
1               5                   10                  15      


Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp Asn Ile Tyr Arg Tyr 
            20                  25                  30          


Ile Met Val Pro Ser Gly Asn Met Gly Val Phe Asp Pro Thr Glu Ile 
        35                  40                  45              


His Asn Arg Gly Gln Leu Lys Ser His Met Lys Glu Ala Met Ile Lys 
    50                  55                  60                  


Leu Gly Phe His Leu Leu Cys Phe Phe Met Tyr Leu Tyr Ser Met Ile 
65                  70                  75                  80  


Leu Ala Leu Ile Asn Asp 
                85      


<210>  7335
<211>  2058
<212>  DNA
<213>  Homosapiens

<400>  7335
acggaaggag cggcggcgac ggaggaggag gatggaggcg gtggtgttcg tcttctctct     60

cctcgattgt tgcgcgctca tcttcctctc ggtctacttc ataattacat tgtctgattt    120

agaatgtgat tacattaatg ctagatcatg ttgctcaaat actgctcatg tcattgcact    180

ggttcatctt ccttctcaac ttacctgttg ccacttggaa tatatatcga tacattatgg    240

tgccgagtgg taacatggga gtgtttgatc caacagaaat acacaatcga gggcagctga    300

agtcacacat gaaagaagcc atgatcaagc ttggtttcca cttgctctgc ttcttcatgt    360

atctttatag tatgatctta gctttgataa atgactgaag ctggagaagc cgtggttgaa    420

gtcagcctac actacagtgc acagttgagg agccagagac ttcttaaatc atccttagaa    480

ccgtgaccat agcagtatat attttcctct tggaacaaaa aactattttt gctgtatttt    540

taccatataa agtatttaaa aaacatgaat tgagtttctg tagatttcta gttctcaact    600

ttagcctgaa cgccaacact tgaaggtgtt tttcatcctc tgtatgttga aggtggttat    660

ttgtatgtag gaacaggact gccatcccag ctttgcatgc caaagaaata aagaacacac    720

tttaaagggc aaactgaaga gatgagcgag caaaggtgcc cttcaggtct actgaaaagt    780

tagagtacaa aacaacactg ttgatctgga caaaagaaga aaaattaccc tttttgcttg    840

tgttgtgaca acttcattta atatggttta aagatttatg agactgtcag ctaaaagtct    900

tttcacaaga atgtcaacag agaatggcat ctcaaaatat atatatttct ttgcacaatt    960

tgtgaaacct tataagccat tttccccagg tacaatgtag ttcctgctga tagaaaggaa   1020

atattttgtc aagagctttc atttaaaagc tactacctcc acaatcaccc ccaaacccag   1080

aaaatcccca ctggctcttg ccagtctggt tttcgtattg cagttattcc aattgtattt   1140

gatctccctg ataacgtatt ttcatgggtt tgggtagaag atgctaatca gattagaagc   1200

aggaatagtt atttgctgtc tgtgaaattg agccttttgg tgcgccacgt ggtgccagat   1260

caacacttct atccctctgc actgaccacg ttgtgaactg ggagaccaaa tgcaagccat   1320

ttcatggaca tagcaatata caaccaaact ctgttccttg gagttatatt gtaaactctt   1380

gcaggtggga gagcagttca cctccttagc tctgtttgcc agctcttaca gggtaaaata   1440

aacctggcaa tttatcctca gtcctagttt gtggtttaat gttgctatct taagcactgg   1500

catttgggca aaacatgact gtgttctgtg ggagaatcca aaggcattat tcactctagt   1560

tgagatagaa ttgggtggct aaacagggtg tgtggtaccc aaaagattaa atgttacatg   1620

tccttttagt ccttgaccag gtctagcctt ggcagaagca agggagccac taagccaaac   1680

tccctgtgca gacagaccat gtttcaaggc tggaagtagt gccctggcaa cacacaaaag   1740

gaacggtgaa atggtaggca aagtgaactt ggctctgctg gcctctttgg ggtcacagaa   1800

attgctcctt gtggtaatct tatatttctg tcaggcacag ggccaagaag ctgtgtaaca   1860

gacattactt tgcttgcatc tctttttcat accttttccc tctgaggcag cttttgctta   1920

gaaaacagtc ccttcactct gcctttcctc ctaacttcct gtgcctcttc atgttctgct   1980

caagcttttt aaagcaacga agctgttgga gaacttaaat ccttgcaact gagagataag   2040

ctacttaaag gcggtaga                                                 2058


<210>  7336
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  7336

Met Leu Asp His Val Ala Gln Ile Leu Leu Met Ser Leu His Trp Phe 
1               5                   10                  15      


Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp Asn Ile Tyr Arg Tyr 
            20                  25                  30          


Ile Met Val Pro Ser Gly Asn Met Gly Val Phe Asp Pro Thr Glu Ile 
        35                  40                  45              


His Asn Arg Gly Gln Leu Lys Ser His Met Lys Glu Ala Met Ile Lys 
    50                  55                  60                  


Leu Gly Phe His Leu Leu Cys Phe Phe Met Tyr Leu Tyr Ser Met Ile 
65                  70                  75                  80  


Leu Ala Leu Ile Asn Asp 
                85      


<210>  7337
<211>  1464
<212>  DNA
<213>  Homosapiens

<400>  7337
cggaaggagc ggcggcgacg gaggaggagg atggaggcgg tggtgttcgt cttctctctc     60

ctcgattgtt gcgcgctcat cttcctctcg gtctacttca taattacatt gtctgattta    120

gaatgtgatt acattaatgc tagatcatgt tgctcaaaat taaacaagtg ggtaattcca    180

gaattgattg gccataccat tgtcactgta ttactgctca tgtcattgca ctggttcatc    240

ttccttctca acttacctgt tgccacttgg aatatatatc gaaatacaca atcgagggca    300

gctgaagtca cacatgaaag aagccatgat caagcttggt ttccacttgc tctgcttctt    360

catgtatctt tatagtatga tcttagcttt gataaatgac tgaagctgga gaagccgtgg    420

ttgaagtcag cctacactac agtgcacagt tgaggagcca gagacttctt aaatcatcct    480

tagaaccgtg accatagcag tatatatttt cctcttggaa caaaaaacta tttttgctgt    540

atttttacca tataaagtat ttaaaaaaca tgaattgagt ttctgtagat ttctagttct    600

caactttagc ctgaacgcca acacttgaag gtgtttttca tcctctgtat gttgaaggtg    660

gttatttgta tgtaggaaca ggactgccat cccagctttg catgccaaag aaataaagaa    720

cacactttaa agggcaaact gaagagatga gcgagcaaag gtgcccttca ggtctactga    780

aaagttagag tacaaaacaa cactgttgat ctggacaaaa gaagaaaaat tacccttttt    840

gcttgtgttg tgacaacttc atttaatatg gtttaaagat ttatgagact gtcagctaaa    900

agtcttttca caagaatgtc aacagagaat ggcatctcaa aatatatata tttctttgca    960

caatttgtga aaccttataa gccattttcc ccaggtacaa tgtagttcct gctgatagaa   1020

aggaaatatt ttgtcaagag ctttcattta aaagctacta cctccacaat cacccccaaa   1080

cccagaaaat ccccactggc tcttgccagt ctggttttcg tattgcagtt attccaattg   1140

tatttgatct ccctgataac gtattttcat gggtttgggt agaagatgct aatcagatta   1200

gaagcaggaa tagttatttg ctgtctgtga aattgagcct tttggtgcgc cacgtggtgc   1260

cagatcaaca cttctatccc tctgcactga ccacgttgtg aactgggaga ccaaatgcaa   1320

gccatttcat ggacatagca atatacaacc aaactctgtt ccttggagtt atattgtaaa   1380

ctcttgcagg tgggagagca gttcacctcc ttagctctgt ttgccagctc ttacagggta   1440

aaataaacct ggcaatttat cctc                                          1464


<210>  7338
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  7338

Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu 
1               5                   10                  15      


Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys 
            20                  25                  30          


Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val 
        35                  40                  45              


Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met 
    50                  55                  60                  


Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp 
65                  70                  75                  80  


Asn Ile Tyr Arg Asn Thr Gln Ser Arg Ala Ala Glu Val Thr His Glu 
                85                  90                  95      


Arg Ser His Asp Gln Ala Trp Phe Pro Leu Ala Leu Leu Leu His Val 
            100                 105                 110         


Ser Leu 
        


<210>  7339
<211>  2063
<212>  DNA
<213>  Homosapiens

<400>  7339
cggaaggagc ggcggcgacg gaggaggagg atggaggcgg tggtgttcgt cttctctctc     60

ctcgattgtt gcgcgctcat cttcctctcg gtctacttca taattacatt gtctgattta    120

gaatgtgatt acattaatgc tagatcatgt tgctcaaaat taaacaagtg ggtaattcca    180

gaattgattg gccataccat tgtcactgta ttactgctca tgtcattgca ctggttcatc    240

ttccttctca acttacctgt tgccacttgg aatatatatc gaaatacaca atcgagggca    300

gctgaagtca cacatgaaag aagccatgat caagcttggt ttccacttgc tctgcttctt    360

catgtatctt tatagtatga tcttagcttt gataaatgac tgaagctgga gaagccgtgg    420

ttgaagtcag cctacactac agtgcacagt tgaggagcca gagacttctt aaatcatcct    480

tagaaccgtg accatagcag tatatatttt cctcttggaa caaaaaacta tttttgctgt    540

atttttacca tataaagtat ttaaaaaaca tgaattgagt ttctgtagat ttctagttct    600

caactttagc ctgaacgcca acacttgaag gtgtttttca tcctctgtat gttgaaggtg    660

gttatttgta tgtaggaaca ggactgccat cccagctttg catgccaaag aaataaagaa    720

cacactttaa agggcaaact gaagagatga gcgagcaaag gtgcccttca ggtctactga    780

aaagttagag tacaaaacaa cactgttgat ctggacaaaa gaagaaaaat tacccttttt    840

gcttgtgttg tgacaacttc atttaatatg gtttaaagat ttatgagact gtcagctaaa    900

agtcttttca caagaatgtc aacagagaat ggcatctcaa aatatatata tttctttgca    960

caatttgtga aaccttataa gccattttcc ccaggtacaa tgtagttcct gctgatagaa   1020

aggaaatatt ttgtcaagag ctttcattta aaagctacta cctccacaat cacccccaaa   1080

cccagaaaat ccccactggc tcttgccagt ctggttttcg tattgcagtt attccaattg   1140

tatttgatct ccctgataac gtattttcat gggtttgggt agaagatgct aatcagatta   1200

gaagcaggaa tagttatttg ctgtctgtga aattgagcct tttggtgcgc cacgtggtgc   1260

cagatcaaca cttctatccc tctgcactga ccacgttgtg aactgggaga ccaaatgcaa   1320

gccatttcat ggacatagca atatacaacc aaactctgtt ccttggagtt atattgtaaa   1380

ctcttgcagg tgggagagca gttcacctcc ttagctctgt ttgccagctc ttacagggta   1440

aaataaacct ggcaatttat cctcagtcct agtttgtggt ttaatgttgc tatcttaagc   1500

actggcattt gggcaaaaca tgactgtgtt ctgtgggaga atccaaaggc attattcact   1560

ctagttgaga tagaattggg tggctaaaca gggtgtgtgg tacccaaaag attaaatgtt   1620

acatgtcctt ttagtccttg accaggtcta gccttggcag aagcaaggga gccactaagc   1680

caaactccct gtgcagacag accatgtttc aaggctggaa gtagtgccct ggcaacacac   1740

aaaaggaacg gtgaaatggt aggcaaagtg aacttggctc tgctggcctc tttggggtca   1800

cagaaattgc tccttgtggt aatcttatat ttctgtcagg cacagggcca agaagctgtg   1860

taacagacat tactttgctt gcatctcttt ttcatacctt ttccctctga ggcagctttt   1920

gcttagaaaa cagtcccttc actctgcctt tcctcctaac ttcctgtgcc tcttcatgtt   1980

ctgctcaagc tttttaaagc aacgaagctg ttggagaact taaatccttg caactgagag   2040

ataagctact taaaggcggt aga                                           2063


<210>  7340
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  7340

Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu 
1               5                   10                  15      


Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys 
            20                  25                  30          


Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val 
        35                  40                  45              


Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met 
    50                  55                  60                  


Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp 
65                  70                  75                  80  


Asn Ile Tyr Arg Asn Thr Gln Ser Arg Ala Ala Glu Val Thr His Glu 
                85                  90                  95      


Arg Ser His Asp Gln Ala Trp Phe Pro Leu Ala Leu Leu Leu His Val 
            100                 105                 110         


Ser Leu 
        


<210>  7341
<211>  1347
<212>  DNA
<213>  Homosapiens

<400>  7341
gaggaggatg gaggcggtgg tgttcgtctt ctctctcctc gattgttgcg cgctcatctt     60

cctctcggtc tacttcataa ttacattgtc tgatttagaa tgtgattaca ttaatgctag    120

atcatgttgc tcaaaattaa acaagtgggt aattccagaa ttgattggcc ataccattgt    180

cactgtatta ctgctcatgt cattgcactg gttcatcttc cttctcaact tacctgttgc    240

cacttggaat atatatcgta tgatcttagc tttgataaat gactgaagct ggagaagccg    300

tggttgaagt cagcctacac tacagtgcac agttgaggag ccagagactt cttaaatcat    360

ccttagaacc gtgaccatag cagtatatat tttcctcttg gaacaaaaaa ctatttttgc    420

tgtattttta ccatataaag tatttaaaaa acatgaattg agtttctgta gatttctagt    480

tctcaacttt agcctgaacg ccaacacttg aaggtgtttt tcatcctctg tatgttgaag    540

gtggttattt gtatgtagga acaggactgc catcccagct ttgcatgcca aagaaataaa    600

gaacacactt taaagggcaa actgaagaga tgagcgagca aaggtgccct tcaggtctac    660

tgaaaagtta gagtacaaaa caacactgtt gatctggaca aaagaagaaa aattaccctt    720

tttgcttgtg ttgtgacaac ttcatttaat atggtttaaa gatttatgag actgtcagct    780

aaaagtcttt tcacaagaat gtcaacagag aatggcatct caaaatatat atatttcttt    840

gcacaatttg tgaaacctta taagccattt tccccaggta caatgtagtt cctgctgata    900

gaaaggaaat attttgtcaa gagctttcat ttaaaagcta ctacctccac aatcaccccc    960

aaacccagaa aatccccact ggctcttgcc agtctggttt tcgtattgca gttattccaa   1020

ttgtatttga tctccctgat aacgtatttt catgggtttg ggtagaagat gctaatcaga   1080

ttagaagcag gaatagttat ttgctgtctg tgaaattgag ccttttggtg cgccacgtgg   1140

tgccagatca acacttctat ccctctgcac tgaccacgtt gtgaactggg agaccaaatg   1200

caagccattt catggacata gcaatataca accaaactct gttccttgga gttatattgt   1260

aaactcttgc aggtgggaga gcagttcacc tccttagctc tgtttgccag ctcttacagg   1320

gtaaaataaa cctggcaatt tatcctc                                       1347


<210>  7342
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  7342

Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu 
1               5                   10                  15      


Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys 
            20                  25                  30          


Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val 
        35                  40                  45              


Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met 
    50                  55                  60                  


Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp 
65                  70                  75                  80  


Asn Ile Tyr Arg Met Ile Leu Ala Leu Ile Asn Asp 
                85                  90          


<210>  7343
<211>  1946
<212>  DNA
<213>  Homosapiens

<400>  7343
gaggaggatg gaggcggtgg tgttcgtctt ctctctcctc gattgttgcg cgctcatctt     60

cctctcggtc tacttcataa ttacattgtc tgatttagaa tgtgattaca ttaatgctag    120

atcatgttgc tcaaaattaa acaagtgggt aattccagaa ttgattggcc ataccattgt    180

cactgtatta ctgctcatgt cattgcactg gttcatcttc cttctcaact tacctgttgc    240

cacttggaat atatatcgta tgatcttagc tttgataaat gactgaagct ggagaagccg    300

tggttgaagt cagcctacac tacagtgcac agttgaggag ccagagactt cttaaatcat    360

ccttagaacc gtgaccatag cagtatatat tttcctcttg gaacaaaaaa ctatttttgc    420

tgtattttta ccatataaag tatttaaaaa acatgaattg agtttctgta gatttctagt    480

tctcaacttt agcctgaacg ccaacacttg aaggtgtttt tcatcctctg tatgttgaag    540

gtggttattt gtatgtagga acaggactgc catcccagct ttgcatgcca aagaaataaa    600

gaacacactt taaagggcaa actgaagaga tgagcgagca aaggtgccct tcaggtctac    660

tgaaaagtta gagtacaaaa caacactgtt gatctggaca aaagaagaaa aattaccctt    720

tttgcttgtg ttgtgacaac ttcatttaat atggtttaaa gatttatgag actgtcagct    780

aaaagtcttt tcacaagaat gtcaacagag aatggcatct caaaatatat atatttcttt    840

gcacaatttg tgaaacctta taagccattt tccccaggta caatgtagtt cctgctgata    900

gaaaggaaat attttgtcaa gagctttcat ttaaaagcta ctacctccac aatcaccccc    960

aaacccagaa aatccccact ggctcttgcc agtctggttt tcgtattgca gttattccaa   1020

ttgtatttga tctccctgat aacgtatttt catgggtttg ggtagaagat gctaatcaga   1080

ttagaagcag gaatagttat ttgctgtctg tgaaattgag ccttttggtg cgccacgtgg   1140

tgccagatca acacttctat ccctctgcac tgaccacgtt gtgaactggg agaccaaatg   1200

caagccattt catggacata gcaatataca accaaactct gttccttgga gttatattgt   1260

aaactcttgc aggtgggaga gcagttcacc tccttagctc tgtttgccag ctcttacagg   1320

gtaaaataaa cctggcaatt tatcctcagt cctagtttgt ggtttaatgt tgctatctta   1380

agcactggca tttgggcaaa acatgactgt gttctgtggg agaatccaaa ggcattattc   1440

actctagttg agatagaatt gggtggctaa acagggtgtg tggtacccaa aagattaaat   1500

gttacatgtc cttttagtcc ttgaccaggt ctagccttgg cagaagcaag ggagccacta   1560

agccaaactc cctgtgcaga cagaccatgt ttcaaggctg gaagtagtgc cctggcaaca   1620

cacaaaagga acggtgaaat ggtaggcaaa gtgaacttgg ctctgctggc ctctttgggg   1680

tcacagaaat tgctccttgt ggtaatctta tatttctgtc aggcacaggg ccaagaagct   1740

gtgtaacaga cattactttg cttgcatctc tttttcatac cttttccctc tgaggcagct   1800

tttgcttaga aaacagtccc ttcactctgc ctttcctcct aacttcctgt gcctcttcat   1860

gttctgctca agctttttaa agcaacgaag ctgttggaga acttaaatcc ttgcaactga   1920

gagataagct acttaaaggc ggtaga                                        1946


<210>  7344
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  7344

Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu 
1               5                   10                  15      


Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys 
            20                  25                  30          


Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val 
        35                  40                  45              


Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met 
    50                  55                  60                  


Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp 
65                  70                  75                  80  


Asn Ile Tyr Arg Met Ile Leu Ala Leu Ile Asn Asp 
                85                  90          


<210>  7345
<211>  351
<212>  DNA
<213>  Homosapiens

<400>  7345
gtcattgcac tggttcatct tccttctcaa cttacctgtt gccacttgga atatatatcg     60

aaatacacaa tcgagggcag ctgaagtcac acatgaaaga agccatgatc aagcttggtt    120

tccacttgct ctgcttcttc atgtatcttt atagtatgat cttagctttg ataaatgact    180

gaagctggag aagccgtggt tgaagtcagc ctacactaca gtgcacagtt gaggagccag    240

agacttctta aatcatcctt agaaccgtga ccatagcagt atatattttc ctcttggaac    300

aaaaaactat ttttgctgta tttttaccat ataaagtatt taaaaaacat g             351


<210>  7346
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  7346

Met Thr Glu Ala Gly Glu Ala Val Val Glu Val Ser Leu His Tyr Ser 
1               5                   10                  15      


Ala Gln Leu Arg Ser Gln Arg Leu Leu Lys Ser Ser Leu Glu Pro 
            20                  25                  30      


<210>  7347
<211>  300
<212>  DNA
<213>  Homosapiens

<400>  7347
ctggtcttga actcctgacc tcagggcagc tgaagtcaca catgaaagaa gccatgatca     60

agcttggttt ccacttgctc tgcttcttca tgtatcttta tagtatgatc ttagctttga    120

taaatgactg aagctggaga agccgtggtt gaagtcagcc tacactacag tgcacagttg    180

aggagccaga gacttcttaa atcatcctta gaaccgtgac catagcagta tatattttcc    240

tcttggaaca aaaaactatt tttgctgtat ttttaccata taaagtattt aaaaaacatg    300


<210>  7348
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  7348

Met Thr Glu Ala Gly Glu Ala Val Val Glu Val Ser Leu His Tyr Ser 
1               5                   10                  15      


Ala Gln Leu Arg Ser Gln Arg Leu Leu Lys Ser Ser Leu Glu Pro 
            20                  25                  30      


<210>  7349
<211>  1192
<212>  DNA
<213>  Homosapiens

<400>  7349
ctggtcttga actcctgacc tcagggcagc tgaagtcaca catgaaagaa gccatgatca     60

agcttggttt ccacttgctc tgcttcttca tgtatcttta tagtatgatc ttagctttga    120

taaatgactg aagctggaga agccgtggtt gaagtcagcc tacactacag tgcacagttg    180

aggagccaga gacttcttaa atcatcctta gaaccgtgac catagcagta tatattttcc    240

tcttggaaca aaaaactatt tttgctgtat ttttaccata taaagtattt aaaaaacatg    300

aattgagttt ctgtagattt ctagttctca actttagcct gaacgccaac acttgaaggt    360

gtttttcatc ctctgtatgt tgaaggtggt tatttgtatg taggaacagg actgccatcc    420

cagctttgca tgccaaagaa ataaagaaca cactttaaag ggcaaactga agagatgagc    480

gagcaaaggt gcccttcagg tctactgaaa agttagagta caaaacaaca ctgttgatct    540

ggacaaaaga agaaaaatta ccctttttgc ttgtgttgtg acaacttcat ttaatatggt    600

ttaaagattt atgagactgt cagctaaaag tcttttcaca agaatgtcaa cagagaatgg    660

catctcaaaa tatatatatt tctttgcaca atttgtgaaa ccttataagc cattttcccc    720

aggtacaatg tagttcctgc tgatagaaag gaaatatttt gtcaagagct ttcatttaaa    780

agctactacc tccacaatca cccccaaacc cagaaaatcc ccactggctc ttgccagtct    840

ggttttcgta ttgcagttat tccaattgta tttgatctcc ctgataacgt attttcatgg    900

gtttgggtag aagatgctaa tcagattaga agcaggaata gttatttgct gtctgtgaaa    960

ttgagccttt tggtgcgcca cgtggtgcca gatcaacact tctatccctc tgcactgacc   1020

acgttgtgaa ctgggagacc aaatgcaagc catttcatgg acatagcaat atacaaccaa   1080

actctgttcc ttggagttat attgtaaact cttgcaggtg ggagagcagt tcacctcctt   1140

agctctgttt gccagctctt acagggtaaa ataaacctgg caatttatcc tc           1192


<210>  7350
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  7350

Met Arg Leu Ser Ala Lys Ser Leu Phe Thr Arg Met Ser Thr Glu Asn 
1               5                   10                  15      


Gly Ile Ser Lys Tyr Ile Tyr Phe Phe Ala Gln Phe Val Lys Pro Tyr 
            20                  25                  30          


Lys Pro Phe Ser Pro Gly Thr Met 
        35                  40  


<210>  7351
<211>  1791
<212>  DNA
<213>  Homosapiens

<400>  7351
ctggtcttga actcctgacc tcagggcagc tgaagtcaca catgaaagaa gccatgatca     60

agcttggttt ccacttgctc tgcttcttca tgtatcttta tagtatgatc ttagctttga    120

taaatgactg aagctggaga agccgtggtt gaagtcagcc tacactacag tgcacagttg    180

aggagccaga gacttcttaa atcatcctta gaaccgtgac catagcagta tatattttcc    240

tcttggaaca aaaaactatt tttgctgtat ttttaccata taaagtattt aaaaaacatg    300

aattgagttt ctgtagattt ctagttctca actttagcct gaacgccaac acttgaaggt    360

gtttttcatc ctctgtatgt tgaaggtggt tatttgtatg taggaacagg actgccatcc    420

cagctttgca tgccaaagaa ataaagaaca cactttaaag ggcaaactga agagatgagc    480

gagcaaaggt gcccttcagg tctactgaaa agttagagta caaaacaaca ctgttgatct    540

ggacaaaaga agaaaaatta ccctttttgc ttgtgttgtg acaacttcat ttaatatggt    600

ttaaagattt atgagactgt cagctaaaag tcttttcaca agaatgtcaa cagagaatgg    660

catctcaaaa tatatatatt tctttgcaca atttgtgaaa ccttataagc cattttcccc    720

aggtacaatg tagttcctgc tgatagaaag gaaatatttt gtcaagagct ttcatttaaa    780

agctactacc tccacaatca cccccaaacc cagaaaatcc ccactggctc ttgccagtct    840

ggttttcgta ttgcagttat tccaattgta tttgatctcc ctgataacgt attttcatgg    900

gtttgggtag aagatgctaa tcagattaga agcaggaata gttatttgct gtctgtgaaa    960

ttgagccttt tggtgcgcca cgtggtgcca gatcaacact tctatccctc tgcactgacc   1020

acgttgtgaa ctgggagacc aaatgcaagc catttcatgg acatagcaat atacaaccaa   1080

actctgttcc ttggagttat attgtaaact cttgcaggtg ggagagcagt tcacctcctt   1140

agctctgttt gccagctctt acagggtaaa ataaacctgg caatttatcc tcagtcctag   1200

tttgtggttt aatgttgcta tcttaagcac tggcatttgg gcaaaacatg actgtgttct   1260

gtgggagaat ccaaaggcat tattcactct agttgagata gaattgggtg gctaaacagg   1320

gtgtgtggta cccaaaagat taaatgttac atgtcctttt agtccttgac caggtctagc   1380

cttggcagaa gcaagggagc cactaagcca aactccctgt gcagacagac catgtttcaa   1440

ggctggaagt agtgccctgg caacacacaa aaggaacggt gaaatggtag gcaaagtgaa   1500

cttggctctg ctggcctctt tggggtcaca gaaattgctc cttgtggtaa tcttatattt   1560

ctgtcaggca cagggccaag aagctgtgta acagacatta ctttgcttgc atctcttttt   1620

catacctttt ccctctgagg cagcttttgc ttagaaaaca gtcccttcac tctgcctttc   1680

ctcctaactt cctgtgcctc ttcatgttct gctcaagctt tttaaagcaa cgaagctgtt   1740

ggagaactta aatccttgca actgagagat aagctactta aaggcggtag a            1791


<210>  7352
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  7352

Met Arg Leu Ser Ala Lys Ser Leu Phe Thr Arg Met Ser Thr Glu Asn 
1               5                   10                  15      


Gly Ile Ser Lys Tyr Ile Tyr Phe Phe Ala Gln Phe Val Lys Pro Tyr 
            20                  25                  30          


Lys Pro Phe Ser Pro Gly Thr Met 
        35                  40  


<210>  7353
<211>  467
<212>  DNA
<213>  Homosapiens

<400>  7353
tcgagggcag ctgaagtcac acatgaaaga agccatgatc aagcttggtt tccacttgct     60

ctgcttcttc atgtatcttt atagtggtag caactgccct tgctaatcac cgtaacctcg    120

gctgagaaag aagaggaagc gaaatccaag atgcagctca gttcatcaaa gcctagcagg    180

tcccctcagc tgccttttca tgcctgccac agactacagt aggacaaaac ctgacctggt    240

ctttgaagtt aagagctaag aaagcttcct atagtagtat ctcccatggc acttaccaca    300

ttctatctgg tattacagtt atttgtatgc aattaatcac tcttagattg tatgttcctg    360

gagggcagaa tatgcccatt catatttgta tcttcttcct tctgctcttg gcacctaaca    420

cagtgccttg cacacaaaca ataaatgatt gttgagtgaa taagtaa                  467


<210>  7354
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  7354

Met Gln Leu Ile Thr Leu Arg Leu Tyr Val Pro Gly Gly Gln Asn Met 
1               5                   10                  15      


Pro Ile His Ile Cys Ile Phe Phe Leu Leu Leu Leu Ala Pro Asn Thr 
            20                  25                  30          


Val Pro Cys Thr Gln Thr Ile Asn Asp Cys 
        35                  40          


<210>  7355
<211>  1936
<212>  DNA
<213>  Homosapiens

<400>  7355
agtcactctt ttttagtgaa aaagtttgga catgaaagat cctaatatat tctttccttt     60

gggtatgaat gattgtcttt tactcaaatg attgttcctt tgtgaacctt agggacgcaa    120

gtctggacaa accaggctct gtaggaacat tcctgagaaa acattagtga cattcatttc    180

ttctttccac agtatgatct tagctttgat aaatgactga agctggagaa gccgtggttg    240

aagtcagcct acactacagt gcacagttga ggagccagag acttcttaaa tcatccttag    300

aaccgtgacc atagcagtat atattttcct cttggaacaa aaaactattt ttgctgtatt    360

tttaccatat aaagtattta aaaaacatga attgagtttc tgtagatttc tagttctcaa    420

ctttagcctg aacgccaaca cttgaaggtg tttttcatcc tctgtatgtt gaaggtggtt    480

atttgtatgt aggaacagga ctgccatccc agctttgcat gccaaagaaa taaagaacac    540

actttaaagg gcaaactgaa gagatgagcg agcaaaggtg cccttcaggt ctactgaaaa    600

gttagagtac aaaacaacac tgttgattcc tggactcaag cagtcctcct gcctcagctt    660

cccaagtagt tgggagtagg tgcacaccac catgcccagc gaattttttg tagagacaga    720

ggtcttgcta tgttgcctag gctggtatca aaattactgg cctcaagcga ttctcctgcc    780

tcggcctccc agatgttggg attactggtg tgagccacca cgcccagctc aaaaacaatt    840

tttttagggg cacttctaca aatcatgaaa gggggataaa agcactgact ttaaaaagcc    900

atgtttaaga tgctataaat gttctcccct tttcattgat tggagagttg tagaggacct    960

tagagatcat tttgtctaac tccctcatcc caaagataaa ctgaggccta gagatcgttc   1020

agggtgttgt aactgggaac atctgaatgc tgaggcctag agatcgttca gggtgttgta   1080

actgggaaca tctgaatgct gaggcctaga gatcgttcag ggtgttgtaa ctgggaacat   1140

ctgaatgctg aggcctagag atcgttcagg gtgttgtaac tgggaacatc tgaatgctga   1200

ggcctagaga tcgttcaggg tgttgtaact gggaacatct gaatgctgag gcctagagat   1260

cgttcagggt gttgtaactg ggaacatctg aatgctgagg cctagagatc gttcagggtg   1320

ttgtaactgg gaacatctga atgctgaggc ctagagatcg ttcagggtgt tgtaactggg   1380

aacatctgaa tgctgaggct tagtccagtg ttctctctcc cttaccactc ctcttcccct   1440

tccctctata atggcagtac ccagggcccg gtccatagac tactatcgag tgctcctatg   1500

tgcatcttag tacgtatcat tttcccttgc ctttttcctt ctatcctttc agtggtagca   1560

actgcccttg ctaatcaccg taacctcggc tgagaaagaa gaggaagcga aatccaagat   1620

gcagctcagt tcatcaaagc ctagcaggtc ccctcagctg ccttttcatg cctgccacag   1680

actacagtag gacaaaacct gacctggtct ttgaagttaa gagctaagaa agcttcctat   1740

agtagtatct cccatggcac ttaccacatt ctatctggta ttacagttat ttgtatgcaa   1800

ttaatcactc ttagattgta tgttcctgga gggcagaata tgcccattca tatttgtatc   1860

ttcttccttc tgctcttggc acctaacaca gtgccttgca cacaaacaat aaatgattgt   1920

tgagtgaata agtaaa                                                   1936


<210>  7356
<211>  67
<212>  PRT
<213>  Homosapiens

<400>  7356

Met Leu Arg Leu Ser Pro Val Phe Ser Leu Pro Tyr His Ser Ser Ser 
1               5                   10                  15      


Pro Ser Leu Tyr Asn Gly Ser Thr Gln Gly Pro Val His Arg Leu Leu 
            20                  25                  30          


Ser Ser Ala Pro Met Cys Ile Leu Val Arg Ile Ile Phe Pro Cys Leu 
        35                  40                  45              


Phe Pro Ser Ile Leu Ser Val Val Ala Thr Ala Leu Ala Asn His Arg 
    50                  55                  60                  


Asn Leu Gly 
65          


<210>  7357
<211>  1366
<212>  DNA
<213>  Homosapiens

<400>  7357
gaaaagttag agtacaaaac aacactgttg atctggacaa aagaagaaaa attacccttt     60

ttgcttgtgt tgtgacaact tcatttaata tggtttaaag atttatgaga ctgtcagcta    120

aaagtctttt cacaagaatg tcaacagaga atggcatctc aaaatatata tatttctttg    180

cacaatttgt gaaaccttat aagccatttt ccccaggtac aatgtagttc ctgctgatag    240

aaaggaaata ttttgtcaag agctttcatt taaaagctac tacctccaca atcaccccca    300

aacccagaaa atccccactg gctcttgcca gtctggtttt cgtattgcag ttattccaat    360

tgtatttgat ctccctgata acgtattttc atgggtttgg gtagaagatg ctaatcagat    420

tagaagcagg aatagttatt tgctgtctgt gaaattgagc cttttggtgc gccacgtggt    480

gccagatcaa cacttctatc cctctgcact gaccacgttg tgaactggga gaccaaatgc    540

aagccatttc atggacatag caatatacaa ccaaactctg ttccttggag ttatattgta    600

aactcttgca ggtgggagag cagttcacct ccttagctct gtttgccagc tcttacaggg    660

taaaataaac ctggcaattt atcctcagtc ctagtttgtg gtttaatgtt gctatcttaa    720

gcactggcat ttgggcaaaa catgactgtg ttctgtggga gaatccaaag gcattattca    780

ctctagttga gatagaattg ggtggctaaa cagggtgtgt ggtacccaaa agattaaatg    840

ttacatgtcc ttttagtcct tgaccaggtc tagccttggc agaagcaagg gagccactaa    900

gccaaactcc ctgtgcagac agaccatgtt tcaaggctgg aagtagtgcc ctggcaacac    960

acaaaaggaa cggtgaaatg tggtagcaac tgcccttgct aatcaccgta acctcggctg   1020

agaaagaaga ggaagcgaaa tccaagatgc agctcagttc atcaaagcct agcaggtccc   1080

ctcagctgcc ttttcatgcc tgccacagac tacagtagga caaaacctga cctggtcttt   1140

gaagttaaga gctaagaaag cttcctatag tagtatctcc catggcactt accacattct   1200

atctggtatt acagttattt gtatgcaatt aatcactctt agattgtatg ttcctggagg   1260

gcagaatatg cccattcata tttgtatctt cttccttctg ctcttggcac ctaacacagt   1320

gccttgcaca caaacaataa atgattgttg agtgaataag taaacc                  1366


<210>  7358
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  7358

Met Gln Leu Ile Thr Leu Arg Leu Tyr Val Pro Gly Gly Gln Asn Met 
1               5                   10                  15      


Pro Ile His Ile Cys Ile Phe Phe Leu Leu Leu Leu Ala Pro Asn Thr 
            20                  25                  30          


Val Pro Cys Thr Gln Thr Ile Asn Asp Cys 
        35                  40          


<210>  7359
<211>  329
<212>  DNA
<213>  Homosapiens

<400>  7359
atagagggaa ggggaagagg agtggtaagg gagagagaac actggactaa gcctcagcat     60

tcagatgttc ccagttacaa caccctgaac gatctctagg cctcagcatt cagatgttcc    120

cagttacaac accctgaacg atctctaggc ctcagcattc agatgttccc agttacaaca    180

ccctgaacga tctctaggcc tcagcattca gatgttccca gttacaacac cctgaacgat    240

ctctaggcct cagtttatct ttgggatgag ggagttagac aaaatgatct ctaaggtcct    300

ctacaactct ccaatcaatg aaaagggga                                      329


<210>  7360
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  7360

Ile Glu Gly Arg Gly Arg Gly Val Val Arg Glu Arg Glu His Trp Thr 
1               5                   10                  15      


Lys Pro Gln His Ser Asp Val Pro Ser Tyr Asn Thr Leu Asn Asp Leu 
            20                  25                  30          


<210>  7361
<211>  6750
<212>  DNA
<213>  Homosapiens

<400>  7361
gctgctgccc ctcccgccgc cgctgctgtc ccccaccgaa gtagcggcca cagcctggtc     60

agcggcagca tcatgcaggc caatggggca ggaggaggag gaggaggtgg cggcggcggc    120

ggtggaggag gagggggcgg cgggggccag ggacagaccc cggaactcgc ctgcttgtcg    180

gcccagaacg gggagtcgtc cccctcgtcg tcgtcgtccg cgggggacct ggcccacgcc    240

aatgggctcc tgccttccgc cccctccgcc gccagcaaca atagcaacag cctgaatgtc    300

aataacgggg ttcccggcgg ggcggccgcc gcatcctcag ccaccgtcgc agctgcctcc    360

gccaccaccg ccgcctcctc ttccttggcc accccagaac tgggcagcag cctcaagaag    420

aagaagcggc tctcccagtc agatgaggat gtcattaggc taataggaca gcacttgaat    480

ggcttagggc tcaaccagac tgttgatctc ctcatgcaag agtcaggatg tcgtttagaa    540

catccttctg ctaccaaatt ccgaaatcat gtcatggaag gagactggga taaggcagaa    600

aatgacctga atgaactaaa gcctttagtg cattctcctc atgctattgt ggtaagaggc    660

gcacttgaaa tctctcaaac gttgttggga ataattgtga ggatgaagtt tttgctgctg    720

cagcagaagt acctagaata cctggaggat ggcaaggtcc tggaggcact tcaagttcta    780

cgctgtgaat tgacgccgct gaaatacaat acagagcgca ttcatgttct tagtgggtat    840

ctgatgtgta gccatgcaga agacctacgt gcaaaagcag aatgggaagg caaagggaca    900

gcttcccgat ctaaactatt ggataaactt cagacctatt taccaccatc agtgatgctt    960

cccccacggc gtttacagac tctcctgcgg caggcggtgg aactacaaag ggatcggtgc   1020

ctatatcaca ataccaaact tgataataat ctagattctg tgtctctgct tatagaccat   1080

gtttgtagta ggaggcagtt cccatgttat acgcagcaga tacttacgga gcattgtaat   1140

gaagtgtggt tctgtaaatt ctctaatgat ggcactaaac tagcaacagg atcaaaagat   1200

acaacagtta tcatatggca agttgatccg gatacacacc tgctaaaact gcttaaaaca   1260

ttagaaggac atgcttatgg cgtttcttat attgcatgga gtccagatga caactatctt   1320

gttgcttgtg gcccagatga ctgctctgag ctttggcttt ggaatgtaca aacaggagaa   1380

ctaaggacaa aaatgagcca gtctcatgaa gacagtttga caagtgtggc ttggaatcca   1440

gatgggaagc gctttgtgac tggaggtcag cgtgggcagt tctatcagtg tgacttagat   1500

ggtaatctcc ttgactcctg ggaaggggta agagtgcaat gcctttggtg cttgagtgat   1560

ggaaagactg ttctggcatc agatacacac cagcgaattc ggggctataa cttcgaggac   1620

cttacagata ggaacatagt acaagaagat catcctatta tgtcttttac tatttcaaaa   1680

aatggccgat tagctttgtt aaatgtagca actcagggag ttcatttatg ggacttgcaa   1740

gacagagttt tagtaagaaa gtatcaaggt gttacacaag ggttttatac aattcattca   1800

tgttttggag gccataatga agacttcatc gctagtggca gtgaagatca caaggtttac   1860

atctggcaca aacgtagtga actgccaatt gcggagctga cagggcacac acgtacagta   1920

aactgtgtga gctggaaccc acagattcca tccatgatgg ccagcgcctc agatgatggc   1980

actgttagaa tatggggacc agcacctttt atagaccacc agaatattga agaggaatgc   2040

agtagcatgg atagttgatg gtgaatttgg agcagacgac ttctgtttaa cttaaaatta   2100

gtcgtatttt aatggcttgg gatttggtgc aaacaaacat gattgatagc tggacagaca   2160

tgctcgtcat gaaaaaagaa ccatttctga agcccgattg gggccaaaca tttacacctt   2220

gcttcatagt aaccagttga gatgaagcac gtcgttagaa cgttgttgga caccatgttg   2280

aattattccc ccatcggttg tgaagaactg tgctacattc aggcttaccc attgaactca   2340

gtatatatat ttttttcctt cctgtctttt gtctggcagg ataccattct tgttgctctt   2400

ctgtgtaatg aagtttaaat gcttgtttgg aaaactttat ttaacagttt agaaggcttg   2460

atagaaagag tgcattagtc tgaagagtat acattggata ggaaagaatt tccttctttt   2520

gtttctccaa atctttccgc cttatttagc ttgagatctt tgcagcttgg ttcatggatt   2580

ctagccttgc ccgttgcgca gtatatactg atccagatga taaaccagtg aactatgtca   2640

aaagcactct caatattaca tttgacaaaa agttttgtac ttttcacata gcttgttgcc   2700

ccgtaaaagg gttaacagca caatttttta aaaataaatt aagaagtatt tataggatta   2760

aagtgacttc atttgtatac atttggaatc taaaccagct taaaaacagt ttcctcaatg   2820

acttagatac acagtataac tgatgctctt ctggaatacc acatgagaca tggtcagaaa   2880

cagtgcttgg aaggacatta cacaagaaat tcagagtaat gctttgaaga tttcccccct   2940

tttgttttat tcctgaagga acatcagtac ccgatcttga agaaattcaa gattcaaaaa   3000

gaattttaaa tacaccaaca tgagacatca gtagtcagtt ggttttcagt aaagcttgtt   3060

ccaagttgtt ctcaacttag gaagtaattt tggtgtgatc tagcaaaaga gtaggaatca   3120

gcgatacaac cactttggaa gtttatagta taattgaaat tattagaaga attcagcagg   3180

ttacagacat acttaaactg ggattaaaac ctcatagtca tttttcttaa ttgcccttaa   3240

tattttgaca tatagggata cataaattta aagaatattt tttctcagtt ttttcagata   3300

ttgccatact gaacctcatt ctaaactggt gctgtggata gtctttccct ctcccctcct   3360

gttttagttt aaggaaaggt ttccttcatg gaaaagcact tttaattttg agaatttcac   3420

atttaaaata agccaaaagc ctgatgttca cattgtgctt ttaaactccg taacagctga   3480

atacaacata acatagtctc ccttgaaatt ccctcccttt ttcagtagag gataaatagg   3540

gtgactccag ctgttggaat gagaatgggg atacccccaa aataagattc tggtgaagaa   3600

aaagtcttgt actaagttcc cctttaggtg tagccaagtc tataatataa ttatgatcat   3660

gaatagactc cagaatccac aaagagaaga gggcttggat gtcaaaaatt cttccattgt   3720

ggggtaggtg gtcggggatg ggagaaaggg aaaagtcagg gaaggggaga agaaagaaaa   3780

acacatttgg ccttaaaata gcatgcattc tcccagaagc ccatagtaaa gaaaatgaca   3840

gatcgtggtc agcagactct tatcaaattg gtatgtaaaa gatttcttca agctccattt   3900

tgcagagacc accacttaga gaatcaaaaa attcctgttt tgatacttct aagttaaaat   3960

atatgttaca gtttatctgg tacttcattt ttcttaacta aaattacttt ttactttaag   4020

cttgaataaa aatcttcatt ggtaactgta tgtaattaag tggcaacttc tctttacctc   4080

agtatagtta aaaaccattc atattttaag tgattcatgt ataccctgaa gccgttaata   4140

caccccagtc tctatggtaa catcactaaa tgtgggcata gaaactccac agctgtttac   4200

aaatttggtt acagtgtgct acggtgcatt tgtaacactc agatttgtgc ccattcaggg   4260

gcaatttggc actcagattc tactctactt cacctaacca cccctagatc tgagttttca   4320

gagtgcttct gaagtacagt ttaaaaacac tttttaaaaa gtggagtaaa agtgaggcac   4380

attttacaag aacataactc ctattaaaac ggagtaacaa ctatgcaaag gtttctatag   4440

cagctaggtg agtttgtttt ccgggtctgt cttaactggc agcttcctgt acatactggt   4500

acttatttgc tgtaaacgtc tgtttcatac atttgccatg cagtgactgt gctcgaaagg   4560

tgaaatcaat ggtaaagaag cctaggattt tatggtatga gaaactgatc gcaggatttt   4620

ctgatccata gctattaatt gaaaacttct gatagtgctg taggctctat agtaggctta   4680

agagtgagtc ttatactatg aagccagcca caagatacta acaaatgtat aaattgaaaa   4740

gtaccaatac tttttgcaca tagatcaaaa tagagtggag aatttgggct ccaaaaatca   4800

ggttagtagg ctcatttcca tgtgcttaaa aatgtttttg ttgttatgca ttgattaagg   4860

gctagagcaa atataaaatt aaatgtcttt ttcctccaaa taattggtta ttaatggtaa   4920

aatgttggac ttggggatta ctgagattag tatgtgggta gtaaagaatt ggagtgggag   4980

ttagtgggga gggatgacaa agcttcagct ttggtttttg tattttttta gtcttcataa   5040

cagctacatt tctgttgctc ttattggcca gataaatgtg ttatattaaa ccaggtaagt   5100

attttaaaca gagaacattt tatttgcata tatccctaca aattggccca ttttattggg   5160

tggggggata aaaaagggat tccctaactt taaataatca gaatatcctg caattgaaag   5220

gagaaaaaaa tccaattttg tcagtatttt cttagtctga aaaaaacagc agtagtaatc   5280

tggtgaatgt tattattagg agtgttctgc ctctacagtg gcatattcca tgacattaat   5340

agaaaaccct tctttcccac ccctccccat cttgacattt tcttttttag gatgttggtt   5400

cctgcaaaca agaactgacc ctatcacctc tgcctcacag tgggtaaata tatcatacat   5460

ctcttgaaag ggaaaatatc catgtcagtt tctttcacag tagaagaatg gctgcttttg   5520

aatggggagg aaagaagaca tttttcttaa tatccttttt gtcccatctc taaaatgtat   5580

aaatattttg atttggtttt actttaattt ctcattcata atttcgcaac tgtccttttg   5640

ggttgccctc caacacatta cttccatttc agaaaccata tctgatttaa tataaactgc   5700

taacttaaga agaggtgaat ttgcatttac acttagacac tttctaaaaa cagggtgaac   5760

ttaattgaaa tttttcagtg ttgttaagct attgttatag tagctgccct atagttacaa   5820

aaataaaaac tataaaaacc catcccctat ctacttaatc cagatagcct ggatttaaca   5880

aaaccaatag tataaaaatg tgtgtgtgtg ttctgtgtgt gtgtgagaga gagagtactt   5940

gattcattaa aaagtcctgg aaacagctgt tctaggatct tgtcattttt actgaaagtc   6000

tcgtgcacat gtgaagtgcc ctctgagttt aaggtttggt taatactggt atatttttat   6060

aagattgaaa ttgtgtcccc atctttaact taaacatttt cattatcagg gtcaatgtgc   6120

tagaactgaa ttgtaacatt tttaggcaca gatggaaaaa aatgttattg gctccttgaa   6180

aatgtgtgtg tgtggcgagg ggaatagatc cacaaaagca tgtatgtact tacaaaccaa   6240

gctgtagaga tcaagaaaag aacttaagtg ttgatctcaa gatttctaaa ttgtcaagat   6300

ttacatggca ttgtggtgga actagttaac acttagagct tttggtatgt aataactatt   6360

tgctatggac tgattaaatg tttcaaaaga ttgtgttctt caattttggt gggttttgat   6420

ttttgttttt ttaactgcct ctcagattat atttacttag tttaaatttc tttgctttat   6480

tcattaaagt ataaaaactt caggtctctg atatttattt tcacttgttt actaattatt   6540

tacaaaacac cctttgttga cttttatttt ataaatgtgt aatgtattaa acgtctttaa   6600

atttttgttc aactgaaact acattaactt tgatttgctt tactgggatt tttttttaaa   6660

gacacttttt ccatgtcagt gcgcagcact taaccagtcg tttgtattcc ctttctttca   6720

atccaataaa cagaatgaat acctaaataa                                    6750


<210>  7362
<211>  661
<212>  PRT
<213>  Homosapiens

<400>  7362

Met Gln Ala Asn Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gln Gly Gln Thr Pro Glu Leu 
            20                  25                  30          


Ala Cys Leu Ser Ala Gln Asn Gly Glu Ser Ser Pro Ser Ser Ser Ser 
        35                  40                  45              


Ser Ala Gly Asp Leu Ala His Ala Asn Gly Leu Leu Pro Ser Ala Pro 
    50                  55                  60                  


Ser Ala Ala Ser Asn Asn Ser Asn Ser Leu Asn Val Asn Asn Gly Val 
65                  70                  75                  80  


Pro Gly Gly Ala Ala Ala Ala Ser Ser Ala Thr Val Ala Ala Ala Ser 
                85                  90                  95      


Ala Thr Thr Ala Ala Ser Ser Ser Leu Ala Thr Pro Glu Leu Gly Ser 
            100                 105                 110         


Ser Leu Lys Lys Lys Lys Arg Leu Ser Gln Ser Asp Glu Asp Val Ile 
        115                 120                 125             


Arg Leu Ile Gly Gln His Leu Asn Gly Leu Gly Leu Asn Gln Thr Val 
    130                 135                 140                 


Asp Leu Leu Met Gln Glu Ser Gly Cys Arg Leu Glu His Pro Ser Ala 
145                 150                 155                 160 


Thr Lys Phe Arg Asn His Val Met Glu Gly Asp Trp Asp Lys Ala Glu 
                165                 170                 175     


Asn Asp Leu Asn Glu Leu Lys Pro Leu Val His Ser Pro His Ala Ile 
            180                 185                 190         


Val Val Arg Gly Ala Leu Glu Ile Ser Gln Thr Leu Leu Gly Ile Ile 
        195                 200                 205             


Val Arg Met Lys Phe Leu Leu Leu Gln Gln Lys Tyr Leu Glu Tyr Leu 
    210                 215                 220                 


Glu Asp Gly Lys Val Leu Glu Ala Leu Gln Val Leu Arg Cys Glu Leu 
225                 230                 235                 240 


Thr Pro Leu Lys Tyr Asn Thr Glu Arg Ile His Val Leu Ser Gly Tyr 
                245                 250                 255     


Leu Met Cys Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu 
            260                 265                 270         


Gly Lys Gly Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr 
        275                 280                 285             


Tyr Leu Pro Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu 
    290                 295                 300                 


Leu Arg Gln Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn 
305                 310                 315                 320 


Thr Lys Leu Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His 
                325                 330                 335     


Val Cys Ser Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr 
            340                 345                 350         


Glu His Cys Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr 
        355                 360                 365             


Lys Leu Ala Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val 
    370                 375                 380                 


Asp Pro Asp Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His 
385                 390                 395                 400 


Ala Tyr Gly Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu 
                405                 410                 415     


Val Ala Cys Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val 
            420                 425                 430         


Gln Thr Gly Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser 
        435                 440                 445             


Leu Thr Ser Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly 
    450                 455                 460                 


Gly Gln Arg Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu 
465                 470                 475                 480 


Asp Ser Trp Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp 
                485                 490                 495     


Gly Lys Thr Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr 
            500                 505                 510         


Asn Phe Glu Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro 
        515                 520                 525             


Ile Met Ser Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn 
    530                 535                 540                 


Val Ala Thr Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu 
545                 550                 555                 560 


Val Arg Lys Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser 
                565                 570                 575     


Cys Phe Gly Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp 
            580                 585                 590         


His Lys Val Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu 
        595                 600                 605             


Leu Thr Gly His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln 
    610                 615                 620                 


Ile Pro Ser Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile 
625                 630                 635                 640 


Trp Gly Pro Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys 
                645                 650                 655     


Ser Ser Met Asp Ser 
            660     


<210>  7363
<211>  6501
<212>  DNA
<213>  Homosapiens

<400>  7363
gctgctgccc ctcccgccgc cgctgctgtc ccccaccgaa gtagcggcca cagcctggtc     60

agcggcagca tcatgcaggc caatggggca ggaggaggag gaggaggtgg cggcggcggc    120

ggtggaggag gagggggcgg cgggggccag ggacagaccc cggaactcgc ctgcttgtcg    180

gcccagaacg gggagtcgtc cccctcgtcg tcgtcgtccg cgggggacct ggcccacgcc    240

aatgggctcc tgccttccgc cccctccgcc gccagcaaca atagcaacag cctgaatgtc    300

aataacgggg ttcccggcgg ggcggccgcc gcatcctcag ccaccgtcgc agctgcctcc    360

gccaccaccg ccgcctcctc ttccttggcc accccagaac tgggcagcag cctcaagaag    420

aagaagcggc tctcccagtc agatgaggat gtcattaggc taataggaca gcacttgaat    480

ggcttagggc tcaaccagac tgttgatctc ctcatgcaag agtcaggatg tcgtttagaa    540

catccttctg ctaccaaatt ccgaaatcat gtcatggaag gagactggga taaggcagaa    600

aatgacctga atgaactaaa gcctttagtg cattctcctc atgctattgt ggtaagaggc    660

gcacttgaaa tctctcaaac gttgttggga ataattgtga ggatgaagtt tttgctgctg    720

cagcagaagt acctagaata cctggaggat ggcaaggtcc tggaggcact tcaagttcta    780

cgctgtgaat tgacgccgct gaaatacaat acagagcgca ttcatgttct tagtgggtat    840

ctgatgtgta gccatgcaga agacctacgt gcaaaagcag aatgggaagg caaagggaca    900

gcttcccgat ctaaactatt ggataaactt cagacctatt taccaccatc agtgatgctt    960

cccccacggc gtttacagac tctcctgcgg caggcggtgg aactacaaag ggatcggtgc   1020

ctatatcaca ataccaaact tgataataat ctagattctg tgtctctgct tatagaccat   1080

gtttgtagta ggaggcagtt cccatgttat acgcagcaga tacttacgga gcattgtaat   1140

gaagtgtggt tctgtaaatt ctctaatgat ggcactaaac tagcaacagg atcaaaagat   1200

acaacagtta tcatatggca agttgatccg gatacacacc tgctaaaact gcttaaaaca   1260

ttagaaggac atgcttatgg cgtttcttat attgcatgga gtccagatga caactatctt   1320

gttgcttgtg gcccagatga ctgctctgag ctttggcttt ggaatgtaca aacaggagaa   1380

ctaaggacaa aaatgagcca gtctcatgaa gacagtttga caagtgtggc ttggaatcca   1440

gatgggaagc gctttgtgac tggaggtcag cgtgggcagt tctatcagtg tgacttagat   1500

ggtaatctcc ttgactcctg ggaaggggta agagtgcaat gcctttggtg cttgagtgat   1560

ggaaagactg ttctggcatc agatacacac cagcgaattc ggggctataa cttcgaggac   1620

cttacagata ggaacatagt acaagaagat catcctatta tgtcttttac tatttcaaaa   1680

aatggccgat tagctttgtt aaatgtagca actcagggag ttcatttatg ggacttgcaa   1740

gacagagttt tagtaagaaa gtatcaaggt gttacacaag ggttttatac aattcattca   1800

tgttttggag gccataatga agacttcatc gctagtggca gtgaagatca caaggtttac   1860

atctggcaca aacgtagtga actgccaatt gcggagctga cagggcacac acgtacagta   1920

aactgtgtga gctggaaccc acagattcca tccatgatgg ccagcgcctc agatgatggc   1980

actgttagaa tatggggacc agcacctttt atagaccacc agaatattga agaggaatgc   2040

agtagcatgg atagttgatg gtgaatttgg agcagacgac ttctgtttaa cttaaaatta   2100

gtcgtatttt aatggcttgg gatttggtgc aaacaaacat gattgatagc tggacagaca   2160

tgctcgtcat gaaaaaagaa ccatttctga agcccgattg gggccaaaca tttacacctt   2220

gcttcatagt aaccagttga gatgaagcac gtcgttagaa cgttgttgga caccatgttg   2280

aattattccc ccatcggttg tgaagaactg tgctacattc aggcttaccc attgaactca   2340

gtatatatat ttttttcctt cctgtctttt gtctggcagg ataccattct tgttgctctt   2400

ctgtgtaatg aagtttaaat gcttgtttgg aaaactttat ttaacagttt agaaggcttg   2460

atagaaagag tgcattagtc tgaagagtat acattggata ggaaagaatt tccttctttt   2520

gtttctccaa atctttccgc cttatttagc ttgagatctt tgcagcttgg ttcatggatt   2580

ctagccttgc ccgttgcgca gtatatactg atccagatga taaaccagtg aactatgtca   2640

aaagcactct caatattaca tttgacaaaa agttttgtac ttttcacata gcttgttgcc   2700

ccgtaaaagg gttaacagca caatttttta aaaataaatt aagaagtatt tataggatta   2760

aagtgacttc atttgtatac atttggaatc taaaccagct taaaaacagt ttcctcaatg   2820

acttagatac acagtataac tgatgctctt ctggaatacc acatgagaca tggtcagaaa   2880

cagtgcttgg aaggacatta cacaagaaat tcagagtaat gctttgaaga tttcccccct   2940

tttgttttat tcctgaagga acatcagtac ccgatcttga agaaattcaa gattcaaaaa   3000

gaattttaaa tacaccaaca tgagacatca gtagtcagtt ggttttcagt aaagcttgtt   3060

ccaagttgtt ctcaacttag gaagtaattt tggtgtgatc tagcaaaaga gtaggaatca   3120

gcgatacaac cactttggaa gtttatagta taattgaaat tattagaaga attcagcagg   3180

ttacagacat acttaaactg ggattaaaac ctcatagtca tttttcttaa ttgcccttaa   3240

tattttgaca tatagggata cataaattta aagaatattt tttctcagtt ttttcagata   3300

ttgccatact gaacctcatt ctaaactggt gctgtggata gtctttccct ctcccctcct   3360

gttttagttt aaggaaaggt ttccttcatg gaaaagcact tttaattttg agaatttcac   3420

atttaaaata agccaaaagc ctgatgttca cattgtgctt ttaaactccg taacagctga   3480

atacaacata acatagtctc ccttgaaatt ccctcccttt ttcagtagag gataaatagg   3540

gtgactccag ctgttggaat gagaatgggg atacccccaa aataagattc tggtgaagaa   3600

aaagtcttgt actaagttcc cctttaggtg tagccaagtc tataatataa ttatgatcat   3660

gaatagactc cagaatccac aaagagaaga gggcttggat gtcaaaaatt cttccattgt   3720

ggggtaggtg gtcggggatg ggagaaaggg aaaagtcagg gaaggggaga agaaagaaaa   3780

acacatttgg ccttaaaata gcatgcattc tcccagaagc ccatagtaaa gaaaatgaca   3840

gatcgtggtc agcagactct tatcaaattg gtatgtaaaa gatttcttca agctccattt   3900

tgcagagacc accacttaga gaatcaaaaa attcctgttt tgatacttct aagttaaaat   3960

atatgttaca gtttatctgg tacttcattt ttcttaacta aaattacttt ttactttaag   4020

cttgaataaa aatcttcatt ggtaactgta tgtaattaag tggcaacttc tctttacctc   4080

agtatagtta aaaaccattc atattttaag tgattcatgt ataccctgaa gccgttaata   4140

caccccagtc tctatggtaa catcactaaa tgtgggcata gaaactccac agctgtttac   4200

aaatttggtt acagtgtgct acggtgcatt tgtaacactc agatttgtgc ccattcaggg   4260

gcaatttggc actcagattc tactctactt cacctaacca cccctagatc tgagttttca   4320

gagtgcttct gaagtacagt ttaaaaacac tttttaaaaa gtggagtaaa agtgaggcac   4380

attttacaag aacataactc ctattaaaac ggagtaacaa ctatgcaaag gtttctatag   4440

cagctaggtg agtttgtttt ccgggtctgt cttaactggc agcttcctgt acatactggt   4500

acttatttgc tgtaaacgtc tgtttcatac atttgccatg cagtgactgt gctcgaaagg   4560

tgaaatcaat ggtaaagaag cctaggattt tatggtatga gaaactgatc gcaggatttt   4620

ctgatccata gctattaatt gaaaacttct gatagtgctg taggctctat agtaggctta   4680

agagtgagtc ttatactatg aagccagcca caagatacta acaaatgtat aaattgaaaa   4740

gtaccaatac tttttgcaca tagatcaaaa tagagtggag aatttgggct ccaaaaatca   4800

ggttagtagg ctcatttcca tgtgcttaaa aatgtttttg ttgttatgca ttgattaagg   4860

gctagagcaa atataaaatt aaatgtcttt ttcctccaaa taattggtta ttaatggtaa   4920

aatgttggac ttggggatta ctgagattag tatgtgggta gtaaagaatt ggagtgggag   4980

ttagtgggga gggatgacaa agcttcagct ttggtttttg tattttttta gtcttcataa   5040

cagctacatt tctgttgctc ttattggcca gataaatgtg ttatattaaa ccaggtaagt   5100

attttaaaca gagaacattt tatttgcata tatccctaca aattggccca ttttattggg   5160

tggggggata aaaaagggat tccctaactt taaataatca gaatatcctg caattgaaag   5220

gagaaaaaaa tccaattttg tcagtatttt cttagtctga aaaaaacagc agtagtaatc   5280

tggtgaatgt tattattagg agtgttctgc ctctacagtg gcatattcca tgacattaat   5340

agaaaaccct tctttcccac ccctccccat cttgacattt tcttttttag gatgttggtt   5400

cctgcaaaca agaactgacc ctatcacctc tgcctcacag tgggtaaata tatcatacat   5460

ctcttgaaag ggaaaatatc catgtcagtt tctttcacag tagaagaatg gctgcttttg   5520

aatggggagg aaagaagaca tttttcttaa tatccttttt gtcccatctc taaaatgtat   5580

aaatattttg atttggtttt actttaattt ctcattcata atttcgcaac tgtccttttg   5640

ggttgccctc caacacatta cttccatttc agaaaccata tctgatttaa tataaactgc   5700

taacttaaga agaggtgaat ttgcatttac acttagacac tttctaaaaa cagggtgaac   5760

ttaattgaaa tttttcagtg ttgttaagct attgttatag tagctgccct atagttacaa   5820

aaataaaaac tataaaaacc catcccctat ctacttaatc cagatagcct ggatttaaca   5880

aaaccaatag tataaaaatg tgtgtgtgtg ttctgtgtgt gtgtgagaga gagagtactt   5940

gattcattaa aaagtcctgg aaacagctgt tctaggatct tgtcattttt actgaaagtc   6000

tcgtgcacat gtgaagtgcc ctctgagttt aaggtttggt taatactggt atatttttat   6060

aagattgaaa ttgtgtcccc atctttaact taaacatttt cattatcagg gtcaatgtgc   6120

tagaactgaa ttgtaacatt tttaggcaca gatggaaaaa aatgttattg gctccttgaa   6180

aatgtgtgtg tgtggcgagg ggaatagatc cacaaaagca tgtatgtact tacaaaccaa   6240

gctgtagaga tcaagaaaag aacttaagtg ttgatctcaa gatttctaaa ttgtcaagat   6300

ttacatggca ttgtggtgga actagttaac acttagagct tttggtatgt aataactatt   6360

tgctatggac tgattaaatg tttcaaaaga ttgtgttctt caattttggt gggttttgat   6420

ttttgttttt ttaactgcct ctcagattat atttacttag tttaaatttc tttgctttat   6480

tcattaaagt ataaaaactt c                                             6501


<210>  7364
<211>  661
<212>  PRT
<213>  Homosapiens

<400>  7364

Met Gln Ala Asn Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gln Gly Gln Thr Pro Glu Leu 
            20                  25                  30          


Ala Cys Leu Ser Ala Gln Asn Gly Glu Ser Ser Pro Ser Ser Ser Ser 
        35                  40                  45              


Ser Ala Gly Asp Leu Ala His Ala Asn Gly Leu Leu Pro Ser Ala Pro 
    50                  55                  60                  


Ser Ala Ala Ser Asn Asn Ser Asn Ser Leu Asn Val Asn Asn Gly Val 
65                  70                  75                  80  


Pro Gly Gly Ala Ala Ala Ala Ser Ser Ala Thr Val Ala Ala Ala Ser 
                85                  90                  95      


Ala Thr Thr Ala Ala Ser Ser Ser Leu Ala Thr Pro Glu Leu Gly Ser 
            100                 105                 110         


Ser Leu Lys Lys Lys Lys Arg Leu Ser Gln Ser Asp Glu Asp Val Ile 
        115                 120                 125             


Arg Leu Ile Gly Gln His Leu Asn Gly Leu Gly Leu Asn Gln Thr Val 
    130                 135                 140                 


Asp Leu Leu Met Gln Glu Ser Gly Cys Arg Leu Glu His Pro Ser Ala 
145                 150                 155                 160 


Thr Lys Phe Arg Asn His Val Met Glu Gly Asp Trp Asp Lys Ala Glu 
                165                 170                 175     


Asn Asp Leu Asn Glu Leu Lys Pro Leu Val His Ser Pro His Ala Ile 
            180                 185                 190         


Val Val Arg Gly Ala Leu Glu Ile Ser Gln Thr Leu Leu Gly Ile Ile 
        195                 200                 205             


Val Arg Met Lys Phe Leu Leu Leu Gln Gln Lys Tyr Leu Glu Tyr Leu 
    210                 215                 220                 


Glu Asp Gly Lys Val Leu Glu Ala Leu Gln Val Leu Arg Cys Glu Leu 
225                 230                 235                 240 


Thr Pro Leu Lys Tyr Asn Thr Glu Arg Ile His Val Leu Ser Gly Tyr 
                245                 250                 255     


Leu Met Cys Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu 
            260                 265                 270         


Gly Lys Gly Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr 
        275                 280                 285             


Tyr Leu Pro Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu 
    290                 295                 300                 


Leu Arg Gln Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn 
305                 310                 315                 320 


Thr Lys Leu Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His 
                325                 330                 335     


Val Cys Ser Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr 
            340                 345                 350         


Glu His Cys Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr 
        355                 360                 365             


Lys Leu Ala Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val 
    370                 375                 380                 


Asp Pro Asp Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His 
385                 390                 395                 400 


Ala Tyr Gly Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu 
                405                 410                 415     


Val Ala Cys Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val 
            420                 425                 430         


Gln Thr Gly Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser 
        435                 440                 445             


Leu Thr Ser Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly 
    450                 455                 460                 


Gly Gln Arg Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu 
465                 470                 475                 480 


Asp Ser Trp Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp 
                485                 490                 495     


Gly Lys Thr Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr 
            500                 505                 510         


Asn Phe Glu Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro 
        515                 520                 525             


Ile Met Ser Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn 
    530                 535                 540                 


Val Ala Thr Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu 
545                 550                 555                 560 


Val Arg Lys Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser 
                565                 570                 575     


Cys Phe Gly Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp 
            580                 585                 590         


His Lys Val Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu 
        595                 600                 605             


Leu Thr Gly His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln 
    610                 615                 620                 


Ile Pro Ser Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile 
625                 630                 635                 640 


Trp Gly Pro Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys 
                645                 650                 655     


Ser Ser Met Asp Ser 
            660     


<210>  7365
<211>  6401
<212>  DNA
<213>  Homosapiens

<400>  7365
gctgctgccc ctcccgccgc cgctgctgtc ccccaccgaa gtagcggcca cagcctggtc     60

agcggcagca tcatgcaggc caatggggca ggaggaggag gaggaggtgg cggcggcggc    120

ggtggaggag gagggggcgg cgggggccag ggacagaccc cggaactcgc ctgcttgtcg    180

gcccagaacg gggagtcgtc cccctcgtcg tcgtcgtccg cgggggacct ggcccacgcc    240

aatgggctcc tgccttccgc cccctccgcc gccagcaaca atagcaacag cctgaatgtc    300

aataacgggg ttcccggcgg ggcggccgcc gcatcctcag ccaccgtcgc agctgcctcc    360

gccaccaccg ccgcctcctc ttccttggcc accccagaac tgggcagcag cctcaagaag    420

aagaagcggc tctcccagtc agatgaggat gtcattaggc taataggaca gcacttgaat    480

ggcttagggc tcaaccagac tgttgatctc ctcatgcaag agtcaggatg tcgtttagaa    540

catccttctg ctaccaaatt ccgaaatcat gtcatggaag gagactggga taaggcagaa    600

aatgacctga atgaactaaa gcctttagtg cattctcctc atgctattgt ggtaagaggc    660

gcacttgaaa tctctcaaac gttgttggga ataattgtga ggatgaagtt tttgctgctg    720

cagcagaagt acctagaata cctggaggat ggcaaggtcc tggaggcact tcaagttcta    780

cgctgtgaat tgacgccgct gaaatacaat acagagcgca ttcatgttct tagtgggtat    840

ctgatgtgta gccatgcaga agacctacgt gcaaaagcag aatgggaagg caaagggaca    900

gcttcccgat ctaaactatt ggataaactt cagacctatt taccaccatc agtgatgctt    960

cccccacggc gtttacagac tctcctgcgg caggcggtgg aactacaaag ggatcggtgc   1020

ctatatcaca ataccaaact tgataataat ctagattctg tgtctctgct tatagaccat   1080

gtttgtagta ggaggcagtt cccatgttat acgcagcaga tacttacgga gcattgtaat   1140

gaagtgtggt tctgtaaatt ctctaatgat ggcactaaac tagcaacagg atcaaaagat   1200

acaacagtta tcatatggca agttgatccg gatacacacc tgctaaaact gcttaaaaca   1260

ttagaaggac atgcttatgg cgtttcttat attgcatgga gtccagatga caactatctt   1320

gttgcttgtg gcccagatga ctgctctgag ctttggcttt ggaatgtaca aacaggagaa   1380

ctaaggacaa aaatgagcca gtctcatgaa gacagtttga caagtgtggc ttggaatcca   1440

gatgggaagc gctttgtgac tggaggtcag cgtgggcagt tctatcagtg tgacttagat   1500

ggtaatctcc ttgactcctg ggaaggggta agagtgcaat gcctttggtg cttgagtgat   1560

ggaaagactg ttctggcatc agatacacac cagcgaattc ggggctataa cttcgaggac   1620

cttacagata ggaacatagt acaagaagat catcctatta tgtcttttac tatttcaaaa   1680

aatggccgat tagctttgtt aaatgtagca actcagggag ttcatttatg ggacttgcaa   1740

gacagagttt tagtaagaaa gtatcaaggt gttacacaag ggttttatac aattcattca   1800

tgttttggag gccataatga agacttcatc gctagtggca gtgaagatca caaggtttac   1860

atctggcaca aacgtagtga actgccaatt gcggagctga cagggcacac acgtacagta   1920

aactgtgtga gctggaaccc acagattcca tccatgatgg ccagcgcctc agatgatggc   1980

actgttagaa tatggggacc agcacctttt atagaccacc agaatattga agaggaatgc   2040

agtagcatgg atagttgatg gtgaatttgg agcagacgac ttctgtttaa cttaaaatta   2100

gtcgtatttt aatggcttgg gatttggtgc aaacaaacat gattgatagc tggacagaca   2160

tgctcgtcat gaaaaaagaa ccatttctga agcccgattg gggccaaaca tttacacctt   2220

gcttcatagt aaccagttga gatgaagcac gtcgttagaa cgttgttgga caccatgttg   2280

aattattccc ccatcggttg tgaagaactg tgctacattc aggcttaccc attgaactca   2340

gtatatatat ttttttcctt cctgtctttt gtctggcagg ataccattct tgttgctctt   2400

ctgtgtaatg aagtttaaat gcttgtttgg aaaactttat ttaacagttt agaaggcttg   2460

atagaaagag tgcattagtc tgaagagtat acattggata ggaaagaatt tccttctttt   2520

gtttctccaa atctttccgc cttatttagc ttgagatctt tgcagcttgg ttcatggatt   2580

ctagccttgc ccgttgcgca gtatatactg atccagatga taaaccagtg aactatgtca   2640

aaagcactct caatattaca tttgacaaaa agttttgtac ttttcacata gcttgttgcc   2700

ccgtaaaagg gttaacagca caatttttta aaaataaatt aagaagtatt tataggatta   2760

aagtgacttc atttgtatac atttggaatc taaaccagct taaaaacagt ttcctcaatg   2820

acttagatac acagtataac tgatgctctt ctggaatacc acatgagaca tggtcagaaa   2880

cagtgcttgg aaggacatta cacaagaaat tcagagtaat gctttgaaga tttcccccct   2940

tttgttttat tcctgaagga acatcagtac ccgatcttga agaaattcaa gattcaaaaa   3000

gaattttaaa tacaccaaca tgagacatca gtagtcagtt ggttttcagt aaagcttgtt   3060

ccaagttgtt ctcaacttag gaagtaattt tggtgtgatc tagcaaaaga gtaggaatca   3120

gcgatacaac cactttggaa gtttatagta taattgaaat tattagaaga attcagcagg   3180

ttacagacat acttaaactg ggattaaaac ctcatagtca tttttcttaa ttgcccttaa   3240

tattttgaca tatagggata cataaattta aagaatattt tttctcagtt ttttcagata   3300

ttgccatact gaacctcatt ctaaactggt gctgtggata gtctttccct ctcccctcct   3360

gttttagttt aaggaaaggt ttccttcatg gaaaagcact tttaattttg agaatttcac   3420

atttaaaata agccaaaagc ctgatgttca cattgtgctt ttaaactccg taacagctga   3480

atacaacata acatagtctc ccttgaaatt ccctcccttt ttcagtagag gataaatagg   3540

gtgactccag ctgttggaat gagaatgggg atacccccaa aataagattc tggtgaagaa   3600

aaagtcttgt actaagttcc cctttaggtg tagccaagtc tataatataa ttatgatcat   3660

gaatagactc cagaatccac aaagagaaga gggcttggat gtcaaaaatt cttccattgt   3720

ggggtaggtg gtcggggatg ggagaaaggg aaaagtcagg gaaggggaga agaaagaaaa   3780

acacatttgg ccttaaaata gcatgcattc tcccagaagc ccatagtaaa gaaaatgaca   3840

gatcgtggtc agcagactct tatcaaattg gtatgtaaaa gatttcttca agctccattt   3900

tgcagagacc accacttaga gaatcaaaaa attcctgttt tgatacttct aagttaaaat   3960

atatgttaca gtttatctgg tacttcattt ttcttaacta aaattacttt ttactttaag   4020

cttgaataaa aatcttcatt ggtaactgta tgtaattaag tggcaacttc tctttacctc   4080

agtatagtta aaaaccattc atattttaag tgattcatgt ataccctgaa gccgttaata   4140

caccccagtc tctatggtaa catcactaaa tgtgggcata gaaactccac agctgtttac   4200

aaatttggtt acagtgtgct acggtgcatt tgtaacactc agatttgtgc ccattcaggg   4260

gcaatttggc actcagattc tactctactt cacctaacca cccctagatc tgagttttca   4320

gagtgcttct gaagtacagt ttaaaaacac tttttaaaaa gtggagtaaa agtgaggcac   4380

attttacaag aacataactc ctattaaaac ggagtaacaa ctatgcaaag gtttctatag   4440

cagctaggtg agtttgtttt ccgggtctgt cttaactggc agcttcctgt acatactggt   4500

acttatttgc tgtaaacgtc tgtttcatac atttgccatg cagtgactgt gctcgaaagg   4560

tgaaatcaat ggtaaagaag cctaggattt tatggtatga gaaactgatc gcaggatttt   4620

ctgatccata gctattaatt gaaaacttct gatagtgctg taggctctat agtaggctta   4680

agagtgagtc ttatactatg aagccagcca caagatacta acaaatgtat aaattgaaaa   4740

gtaccaatac tttttgcaca tagatcaaaa tagagtggag aatttgggct ccaaaaatca   4800

ggttagtagg ctcatttcca tgtgcttaaa aatgtttttg ttgttatgca ttgattaagg   4860

gctagagcaa atataaaatt aaatgtcttt ttcctccaaa taattggtta ttaatggtaa   4920

aatgttggac ttggggatta ctgagattag tatgtgggta gtaaagaatt ggagtgggag   4980

ttagtgggga gggatgacaa agcttcagct ttggtttttg tattttttta gtcttcataa   5040

cagctacatt tctgttgctc ttattggcca gataaatgtg ttatattaaa ccaggtaagt   5100

attttaaaca gagaacattt tatttgcata tatccctaca aattggccca ttttattggg   5160

tggggggata aaaaagggat tccctaactt taaataatca gaatatcctg caattgaaag   5220

gagaaaaaaa tccaattttg tcagtatttt cttagtctga aaaaaacagc agtagtaatc   5280

tggtgaatgt tattattagg agtgttctgc ctctacagtg gcatattcca tgacattaat   5340

agaaaaccct tctttcccac ccctccccat cttgacattt tcttttttag gatgttggtt   5400

cctgcaaaca agaactgacc ctatcacctc tgcctcacag tgggtaaata tatcatacat   5460

ctcttgaaag ggaaaatatc catgtcagtt tctttcacag tagaagaatg gctgcttttg   5520

aatggggagg aaagaagaca tttttcttaa tatccttttt gtcccatctc taaaatgtat   5580

aaatattttg atttggtttt actttaattt ctcattcata atttcgcaac tgtccttttg   5640

ggttgccctc caacacatta cttccatttc agaaaccata tctgatttaa tataaactgc   5700

taacttaaga agaggtgaat ttgcatttac acttagacac tttctaaaaa cagggtgaac   5760

ttaattgaaa tttttcagtg ttgttaagct attgttatag tagctgccct atagttacaa   5820

aaataaaaac tataaaaacc catcccctat ctacttaatc cagatagcct ggatttaaca   5880

aaaccaatag tataaaaatg tgtgtgtgtg ttctgtgtgt gtgtgagaga gagagtactt   5940

gattcattaa aaagtcctgg aaacagctgt tctaggatct tgtcattttt actgaaagtc   6000

tcgtgcacat gtgaagtgcc ctctgagttt aaggtttggt taatactggt atatttttat   6060

aagattgaaa ttgtgtcccc atctttaact taaacatttt cattatcagg gtcaatgtgc   6120

tagaactgaa ttgtaacatt tttaggcaca gatggaaaaa aatgttattg gctccttgaa   6180

aatgtgtgtg tgtggcgagg ggaatagatc cacaaaagca tgtatgtact tacaaaccaa   6240

gctgtagaga tcaagaaaag aacttaagtg ttgatctcaa gatttctaaa ttgtcaagat   6300

ttacatggca ttgtggtgga actagttaac acttagagct tttggtatgt aataactatt   6360

tgctatggac tgattaaatg tttcaaaaga ttgtgttctt c                       6401


<210>  7366
<211>  661
<212>  PRT
<213>  Homosapiens

<400>  7366

Met Gln Ala Asn Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gln Gly Gln Thr Pro Glu Leu 
            20                  25                  30          


Ala Cys Leu Ser Ala Gln Asn Gly Glu Ser Ser Pro Ser Ser Ser Ser 
        35                  40                  45              


Ser Ala Gly Asp Leu Ala His Ala Asn Gly Leu Leu Pro Ser Ala Pro 
    50                  55                  60                  


Ser Ala Ala Ser Asn Asn Ser Asn Ser Leu Asn Val Asn Asn Gly Val 
65                  70                  75                  80  


Pro Gly Gly Ala Ala Ala Ala Ser Ser Ala Thr Val Ala Ala Ala Ser 
                85                  90                  95      


Ala Thr Thr Ala Ala Ser Ser Ser Leu Ala Thr Pro Glu Leu Gly Ser 
            100                 105                 110         


Ser Leu Lys Lys Lys Lys Arg Leu Ser Gln Ser Asp Glu Asp Val Ile 
        115                 120                 125             


Arg Leu Ile Gly Gln His Leu Asn Gly Leu Gly Leu Asn Gln Thr Val 
    130                 135                 140                 


Asp Leu Leu Met Gln Glu Ser Gly Cys Arg Leu Glu His Pro Ser Ala 
145                 150                 155                 160 


Thr Lys Phe Arg Asn His Val Met Glu Gly Asp Trp Asp Lys Ala Glu 
                165                 170                 175     


Asn Asp Leu Asn Glu Leu Lys Pro Leu Val His Ser Pro His Ala Ile 
            180                 185                 190         


Val Val Arg Gly Ala Leu Glu Ile Ser Gln Thr Leu Leu Gly Ile Ile 
        195                 200                 205             


Val Arg Met Lys Phe Leu Leu Leu Gln Gln Lys Tyr Leu Glu Tyr Leu 
    210                 215                 220                 


Glu Asp Gly Lys Val Leu Glu Ala Leu Gln Val Leu Arg Cys Glu Leu 
225                 230                 235                 240 


Thr Pro Leu Lys Tyr Asn Thr Glu Arg Ile His Val Leu Ser Gly Tyr 
                245                 250                 255     


Leu Met Cys Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu 
            260                 265                 270         


Gly Lys Gly Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr 
        275                 280                 285             


Tyr Leu Pro Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu 
    290                 295                 300                 


Leu Arg Gln Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn 
305                 310                 315                 320 


Thr Lys Leu Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His 
                325                 330                 335     


Val Cys Ser Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr 
            340                 345                 350         


Glu His Cys Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr 
        355                 360                 365             


Lys Leu Ala Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val 
    370                 375                 380                 


Asp Pro Asp Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His 
385                 390                 395                 400 


Ala Tyr Gly Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu 
                405                 410                 415     


Val Ala Cys Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val 
            420                 425                 430         


Gln Thr Gly Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser 
        435                 440                 445             


Leu Thr Ser Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly 
    450                 455                 460                 


Gly Gln Arg Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu 
465                 470                 475                 480 


Asp Ser Trp Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp 
                485                 490                 495     


Gly Lys Thr Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr 
            500                 505                 510         


Asn Phe Glu Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro 
        515                 520                 525             


Ile Met Ser Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn 
    530                 535                 540                 


Val Ala Thr Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu 
545                 550                 555                 560 


Val Arg Lys Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser 
                565                 570                 575     


Cys Phe Gly Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp 
            580                 585                 590         


His Lys Val Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu 
        595                 600                 605             


Leu Thr Gly His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln 
    610                 615                 620                 


Ile Pro Ser Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile 
625                 630                 635                 640 


Trp Gly Pro Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys 
                645                 650                 655     


Ser Ser Met Asp Ser 
            660     


<210>  7367
<211>  4523
<212>  DNA
<213>  Homosapiens

<400>  7367
gccaccgtcg cagctgcctc cgccaccacc gccgcctcct cttccttggc caccccagaa     60

ctgggcagca gcctcaagaa gaagaagcgg ctctcccagt cagatgagga tgtcattagg    120

ctaataggac agcacttgaa tggcttaggg ctcaagcaga aaatgacctg aatgaactaa    180

agcctttagt gcattctcct catgctattg tggtaagagg cgcacttgaa atctctcaaa    240

cgttgttggg aataattgtg gcacaaacat tttctgaaac ttccatcaac ttttttcccc    300

tgactgctgc tttctgtcat gtcagaggat gaagtttttg ctgctgcagc agaagtacct    360

agaatacctg gaggatggca aggtcctgga ggcacttcaa gttctacgct gtgaattgac    420

gccgctgaaa tacaatacag agcgcattca tgttcttagt gggtatctga tgtgtagcca    480

tgcagaagac ctacgtgcaa aagcagaatg ggaaggcaaa gggacagctt cccgatctaa    540

actattggat aaacttcaga cctatttacc accatcagtg atgcttcccc cacggcgttt    600

acagactctc ctgcggcagg cggtggaact acaaagggat cggtgcctat atcacaatac    660

caaacttgat aataatctag attctgtgtc tctgcttata gaccatgttt gtagtaggag    720

gcagttccca tgttatacgc agcagatact tacggagcat tgtaatgaag tgtggttctg    780

taaattctct aatgatggca ctaaactagc aacaggatca aaagatacaa cagttatcat    840

atggcaagtt gatccggata cacacctgct aaaactgctt aaaacattag aaggacatgc    900

ttatggcgtt tcttatattg catggagtcc agatgacaac tatcttgttg cttgtggccc    960

agatgactgc tctgagcttt ggctttggaa tgtacaaaca ggagaactaa ggacaaaaat   1020

gagccagtct catgaagaca gtttgacaag tgtggcttgg aatccagatg ggaagcgctt   1080

tgtgactgga ggtcagcgtg ggcagttcta tcagtgtgac ttagatggta atctccttga   1140

ctcctgggaa ggggtaagag tgcaatgcct ttggtgcttg agtgatggaa agactgttct   1200

ggcatcagat acacaccagc gaattcgggg ctataacttc gaggacctta cagataggaa   1260

catagtacaa gaagatcatc ctattatgtc ttttactatt tcaaaaaatg gccgattagc   1320

tttgttaaat gtagcaactc agggagttca tttatgggac ttgcaagaca gagttttagt   1380

aagaaagtat caaggtgtta cacaagggtt ttatacaatt cattcatgtt ttggaggcca   1440

taatgaagac ttcatcgcta gtggcagtga agatcacaag gtttacatct ggcacaaacg   1500

tagtgaactg ccaattgcgg agctgacagg gcacacacgt acagtaaact gtgtgagctg   1560

gaacccacag attccatcca tgatggccag cgcctcagat gatggcactg ttagaatatg   1620

gggaccagca ccttttatag accaccagaa tattgaagag gaatgcagta gcatggatag   1680

ttgatggtga atttggagca gacgacttct gtttaactta aaattagtcg tattttaatg   1740

gcttgggatt tggtgcaaac aaacatgatt gatagctgga cagacatgct cgtcatgaaa   1800

aaagaaccat ttctgaagcc cgattggggc caaacattta caccttgctt catagtaacc   1860

agttgagatg aagcacgtcg ttagaacgtt gttggacacc atgttgaatt attcccccat   1920

cggttgtgaa gaactgtgct acattcaggc ttacccattg aactcagtat atatattttt   1980

ttccttcctg tcttttgtct ggcaggatac cattcttgtt gctcttctgt gtaatgaagt   2040

ttaaatgctt gtttggaaaa ctttatttaa cagtttagaa ggcttgatag aaagagtgca   2100

ttagtctgaa gagtatacat tggataggaa agaatttcct tcttttgttt ctccaaatct   2160

ttccgcctta tttagcttga gatctttgca gcttggttca tggattctag ccttgcccgt   2220

tgcgcagtat atactgatcc agatgataaa ccagtgaact atgtcaaaag cactctcaat   2280

attacatttg acaaaaagtt ttgtactttt cacatagctt gttgccccgt aaaagggtta   2340

acagcacaat tttttaaaaa taaattaaga agtatttata ggattaaagt gacttcattt   2400

gtatacattt ggaatctaaa ccagcttaaa aacagtttcc tcaatgactt agatacacag   2460

tataactgat gctcttctgg aataccacat gagacatggt cagaaacagt gcttggaagg   2520

acattacaca agaaattcag agtaatgctt tgaagatttc cccccttttg ttttattcct   2580

gaaggaacat cagtacccga tcttgaagaa attcaagatt caaaaagaat tttaaataca   2640

ccaacatgag acatcagtag tcagttggtt ttcagtaaag cttgttccaa gttgttctca   2700

acttaggaag taattttggt gtgatctagc aaaagagtag gaatcagcga tacaaccact   2760

ttggaagttt atagtataat tgaaattatt agaagaattc agcaggttac agacatactt   2820

aaactgggat taaaacctca tagtcatttt tcttaattgc ccttaatatt ttgacatata   2880

gggatacata aatttaaaga atattttttc tcagtttttt cagatattgc catactgaac   2940

ctcattctaa actggtgctg tggatagtct ttccctctcc cctcctgttt tagtttaagg   3000

aaaggtttcc ttcatggaaa agcactttta attttgagaa tttcacattt aaaataagcc   3060

aaaagcctga tgttcacatt gtgcttttaa actccgtaac agctgaatac aacataacat   3120

agtctccctt gaaattccct ccctttttca gtagaggata aatagggtga ctccagctgt   3180

tggaatgaga atggggatac ccccaaaata agattctggt gaagaaaaag tcttgtacta   3240

agttcccctt taggtgtagc caagtctata atataattat gatcatgaat agactccaga   3300

atccacaaag agaagagggc ttggatgtca aaaattcttc cattgtgggg taggtggtcg   3360

gggatgggag aaagggaaaa gtcagggaag gggagaagaa agaaaaacac atttggcctt   3420

aaaatagcat gcattctccc agaagcccat agtaaagaaa atgacagatc gtggtcagca   3480

gactcttatc aaattggtat gtaaaagatt tcttcaagct ccattttgca gagaccacca   3540

cttagagaat caaaaaattc ctgttttgat acttctaagt taaaatatat gttacagttt   3600

atctggtact tcatttttct taactaaaat tactttttac tttaagcttg aataaaaatc   3660

ttcattggta actgtatgta attaagtggc aacttctctt tacctcagta tagttaaaaa   3720

ccattcatat tttaagtgat tcatgtatac cctgaagccg ttaatacacc ccagtctcta   3780

tggtaacatc actaaatgtg ggcatagaaa ctccacagct gtttacaaat ttggttacag   3840

tgtgctacgg tgcatttgta acactcagat ttgtgcccat tcaggggcaa tttggcactc   3900

agattctact ctacttcacc taaccacccc tagatctgag ttttcagagt gcttctgaag   3960

tacagtttaa aaacactttt taaaaagtgg agtaaaagtg aggcacattt tacaagaaca   4020

taactcctat taaaacggag taacaactat gcaaaggttt ctatagcagc taggtgagtt   4080

tgttttccgg gtctgtctta actggcagct tcctgtacat actggtactt atttgctgta   4140

aacgtctgtt tcatacattt gccatgcagt gactgtgctc gaaaggtgaa atcaatggta   4200

aagaagccta ggattttatg gtatgagaaa ctgatcgcag gattttctga tccatagcta   4260

ttaattgaaa acttctgata gtgctgtagg ctctatagta ggcttaagag tgagtcttat   4320

actatgaagc cagccacaag atactaacaa atgtataaat tgaaaagtac caatactttt   4380

tgcacataga tcaaaataga gtggagaatt tgggctccaa aaatcaggtt agtaggctca   4440

tttccatgtg cttaaaaatg tttttgttgt tatgcattga ttaagggcta gagcaaatat   4500

aaaattaaat gtctttttcc tcc                                           4523


<210>  7368
<211>  451
<212>  PRT
<213>  Homosapiens

<400>  7368

Met Lys Phe Leu Leu Leu Gln Gln Lys Tyr Leu Glu Tyr Leu Glu Asp 
1               5                   10                  15      


Gly Lys Val Leu Glu Ala Leu Gln Val Leu Arg Cys Glu Leu Thr Pro 
            20                  25                  30          


Leu Lys Tyr Asn Thr Glu Arg Ile His Val Leu Ser Gly Tyr Leu Met 
        35                  40                  45              


Cys Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu Gly Lys 
    50                  55                  60                  


Gly Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr Tyr Leu 
65                  70                  75                  80  


Pro Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu Leu Arg 
                85                  90                  95      


Gln Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn Thr Lys 
            100                 105                 110         


Leu Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His Val Cys 
        115                 120                 125             


Ser Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr Glu His 
    130                 135                 140                 


Cys Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr Lys Leu 
145                 150                 155                 160 


Ala Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val Asp Pro 
                165                 170                 175     


Asp Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His Ala Tyr 
            180                 185                 190         


Gly Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu Val Ala 
        195                 200                 205             


Cys Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val Gln Thr 
    210                 215                 220                 


Gly Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser Leu Thr 
225                 230                 235                 240 


Ser Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly Gly Gln 
                245                 250                 255     


Arg Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu Asp Ser 
            260                 265                 270         


Trp Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp Gly Lys 
        275                 280                 285             


Thr Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr Asn Phe 
    290                 295                 300                 


Glu Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro Ile Met 
305                 310                 315                 320 


Ser Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn Val Ala 
                325                 330                 335     


Thr Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu Val Arg 
            340                 345                 350         


Lys Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser Cys Phe 
        355                 360                 365             


Gly Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp His Lys 
    370                 375                 380                 


Val Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu Leu Thr 
385                 390                 395                 400 


Gly His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln Ile Pro 
                405                 410                 415     


Ser Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile Trp Gly 
            420                 425                 430         


Pro Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys Ser Ser 
        435                 440                 445             


Met Asp Ser 
    450     


<210>  7369
<211>  4897
<212>  DNA
<213>  Homosapiens

<400>  7369
gctgctgccc ctcccgccgc cgctgctgtc ccccaccgaa gtagcggcca cagcctggtc     60

agcggcagca tcatgcaggc caatggggca ggaggaggag gaggaggtgg cggcggcggc    120

ggtggaggag gagggggcgg cgggggccag ggacagaccc cggaactcgc ctgcttgtcg    180

gcccagaacg gggagtcgtc cccctcgtcg tcgtcgtccg cgggggacct ggcccacgcc    240

aatgggctcc tgccttccgc cccctccgcc gccagcaaca atagcaacag cctgaatgtc    300

aataacgggg ttcccggcgg ggcggccgcc gcatcctcag ccaccgtcgc agctgcctcc    360

gccaccaccg ccgcctcctc ttccttggcc accccagaac tgggcagcag cctcaagaag    420

aagaagcggc tctcccagtc agatgaggat gtcattaggc taataggaca gcacttgaat    480

ggcttagggc tcaaccagac tgttgatctc ctcatgcaag agtcaggatg tcgtttagaa    540

catccttctg ctaccaaatt ccgaaatcat gtcatggaag gagactggga taaggcagaa    600

aatgacctga atgaactaaa gcctttagtg cattctcctc atgctattgt ggtaagaggc    660

gcacttgaaa tctctcaaac gttgttggga ataattgtga ggatgaagtt tttgctgctg    720

cagcagaagt acctagaata cctggaggat ggcaaggtcc tggaggcact tcaagttcta    780

cgctgtgaat tgacgccgct gaaatacaat acagagcgca ttcatgttct tagtgggtat    840

ctgatgtgta gccatgcaga agacctacgt gcaaaagcag aatgggaagg caaagggaca    900

gcttcccgat ctaaactatt ggataaactt cagacctatt taccaccatc agtgatgctt    960

cccccacggc gtttacagac tctcctgcgg caggcggtgg aactacaaag ggatcggtgc   1020

ctatatcaca ataccaaact tgataataat ctagattctg tgtctctgct tatagaccat   1080

gtttgtagta ggaggcagtt cccatgttat acgcagcaga tacttacgga gcattgtaat   1140

gaagtgtggt tctgtaaatt ctctaatgat ggcactaaac tagcaacagg atcaaaagat   1200

acaacagtta tcatatggca agttgatccg gatacacacc tgctaaaact gcttaaaaca   1260

ttagaaggac atgcttatgg cgtttcttat attgcatgga gtccagatga caactatctt   1320

gttgcttgtg gcccagatga ctgctctgag ctttggcttt ggaatgtaca aacaggagaa   1380

ctaaggacaa aaatgagcca gtctcatgaa gacagtttga caagtgtggc ttggaatcca   1440

gatgggaagc gctttgtgac tggaggtcag cgtgggcagt tctatcagtg tgacttagat   1500

ggtaatctcc ttgactcctg ggaaggggta agagtgcaat gcctttggtg cttgagtgat   1560

ggaaagactg ttctggcatc agatacacac cagcgaattc ggggctataa cttcgaggac   1620

cttacagata ggaacatagt acaagaagat catcctatta tgtcttttac tatttcaaaa   1680

aatggccgat tagctttgtt aaatgtagca actcagggag ttcatttatg ggacttgcaa   1740

gacagagttt tagtaagaaa gtatcaaggt gttacacaag ggttttatac aattcattca   1800

tgttttggag gccataatga agacttcatc gctagtggca gtgaagatca caaggtttac   1860

atctggcaca aacgtagtga actgccaatt gcggagctga cagggcacac acgtacagta   1920

aactgtgtga gctggaaccc acagattcca tccatgatgg ccagcgcctc agatgatggc   1980

actgttagaa tatggggacc agcacctttt atagaccacc agaatattga agaggaatgc   2040

agtagcatgg atagttgatg gtgaatttgg agcagacgac ttctgtttaa cttaaaatta   2100

gtcgtatttt aatggcttgg gatttggtgc aaacaaacat gattgatagc tggacagaca   2160

tgctcgtcat gaaaaaagaa ccatttctga agcccgattg gggccaaaca tttacacctt   2220

gcttcatagt aaccagttga gatgaagcac gtcgttagaa cgttgttgga caccatgttg   2280

aattattccc ccatcggttg tgaagaactg tgctacattc aggcttaccc attgaactca   2340

gtatatatat ttttttcctt cctgtctttt gtctggcagg ataccattct tgttgctctt   2400

ctgtgtaatg aagtttaaat gcttgtttgg aaaactttat ttaacagttt agaaggcttg   2460

atagaaagag tgcattagtc tgaagagtat acattggata ggaaagaatt tccttctttt   2520

gtttctccaa atctttccgc cttatttagc ttgagatctt tgcagcttgg ttcatggatt   2580

ctagccttgc ccgttgcgca gtatatactg atccagatga taaaccagtg aactatgtca   2640

aaagcactct caatattaca tttgacaaaa agttttgtac ttttcacata gcttgttgcc   2700

ccgtaaaagg gttaacagca caatttttta aaaataaatt aagaagtatt tataggatta   2760

aagtgacttc atttgtatac atttggaatc taaaccagct taaaaacagt ttcctcaatg   2820

acttagatac acagtataac tgatgctctt ctggaatacc acatgagaca tggtcagaaa   2880

cagtgcttgg aaggacatta cacaagaaat tcagagtaat gctttgaaga tttcccccct   2940

tttgttttat tcctgaagga acatcagtac ccgatcttga agaaattcaa gattcaaaaa   3000

gaattttaaa tacaccaaca tgagacatca gtagtcagtt ggttttcagt aaagcttgtt   3060

ccaagttgtt ctcaacttag gaagtaattt tggtgtgatc tagcaaaaga gtaggaatca   3120

gcgatacaac cactttggaa gtttatagta taattgaaat tattagaaga attcagcagg   3180

ttacagacat acttaaactg ggattaaaac ctcatagtca tttttcttaa ttgcccttaa   3240

tattttgaca tatagggata cataaattta aagaatattt tttctcagtt ttttcagata   3300

ttgccatact gaacctcatt ctaaactggt gctgtggata gtctttccct ctcccctcct   3360

gttttagttt aaggaaaggt ttccttcatg gaaaagcact tttaattttg agaatttcac   3420

atttaaaata agccaaaagc ctgatgttca cattgtgctt ttaaactccg taacagctga   3480

atacaacata acatagtctc ccttgaaatt ccctcccttt ttcagtagag gataaatagg   3540

gtgactccag ctgttggaat gagaatgggg atacccccaa aataagattc tggtgaagaa   3600

aaagtcttgt actaagttcc cctttaggtg tagccaagtc tataatataa ttatgatcat   3660

gaatagactc cagaatccac aaagagaaga gggcttggat gtcaaaaatt cttccattgt   3720

ggggtaggtg gtcggggatg ggagaaaggg aaaagtcagg gaaggggaga agaaagaaaa   3780

acacatttgg ccttaaaata gcatgcattc tcccagaagc ccatagtaaa gaaaatgaca   3840

gatcgtggtc agcagactct tatcaaattg gtatgtaaaa gatttcttca agctccattt   3900

tgcagagacc accacttaga gaatcaaaaa attcctgttt tgatacttct aagttaaaat   3960

atatgttaca gtttatctgg tacttcattt ttcttaacta aaattacttt ttactttaag   4020

cttgaataaa aatcttcatt ggtaactgta tgtaattaag tggcaacttc tctttacctc   4080

agtatagtta aaaaccattc atattttaag tgattcatgt ataccctgaa gccgttaata   4140

caccccagtc tctatggtaa catcactaaa tgtgggcata gaaactccac agctgtttac   4200

aaatttggtt acagtgtgct acggtgcatt tgtaacactc agatttgtgc ccattcaggg   4260

gcaatttggc actcagattc tactctactt cacctaacca cccctagatc tgagttttca   4320

gagtgcttct gaagtacagt ttaaaaacac tttttaaaaa gtggagtaaa agtgaggcac   4380

attttacaag aacataactc ctattaaaac ggagtaacaa ctatgcaaag gtttctatag   4440

cagctaggtg agtttgtttt ccgggtctgt cttaactggc agcttcctgt acatactggt   4500

acttatttgc tgtaaacgtc tgtttcatac atttgccatg cagtgactgt gctcgaaagg   4560

tgaaatcaat ggtaaagaag cctaggattt tatggtatga gaaactgatc gcaggatttt   4620

ctgatccata gctattaatt gaaaacttct gatagtgctg taggctctat agtaggctta   4680

agagtgagtc ttatactatg aagccagcca caagatacta acaaatgtat aaattgaaaa   4740

gtaccaatac tttttgcaca tagatcaaaa tagagtggag aatttgggct ccaaaaatca   4800

ggttagtagg ctcatttcca tgtgcttaaa aatgtttttg ttgttatgca ttgattaagg   4860

gctagagcaa atataaaatt aaatgtcttt ttcctcc                            4897


<210>  7370
<211>  661
<212>  PRT
<213>  Homosapiens

<400>  7370

Met Gln Ala Asn Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gln Gly Gln Thr Pro Glu Leu 
            20                  25                  30          


Ala Cys Leu Ser Ala Gln Asn Gly Glu Ser Ser Pro Ser Ser Ser Ser 
        35                  40                  45              


Ser Ala Gly Asp Leu Ala His Ala Asn Gly Leu Leu Pro Ser Ala Pro 
    50                  55                  60                  


Ser Ala Ala Ser Asn Asn Ser Asn Ser Leu Asn Val Asn Asn Gly Val 
65                  70                  75                  80  


Pro Gly Gly Ala Ala Ala Ala Ser Ser Ala Thr Val Ala Ala Ala Ser 
                85                  90                  95      


Ala Thr Thr Ala Ala Ser Ser Ser Leu Ala Thr Pro Glu Leu Gly Ser 
            100                 105                 110         


Ser Leu Lys Lys Lys Lys Arg Leu Ser Gln Ser Asp Glu Asp Val Ile 
        115                 120                 125             


Arg Leu Ile Gly Gln His Leu Asn Gly Leu Gly Leu Asn Gln Thr Val 
    130                 135                 140                 


Asp Leu Leu Met Gln Glu Ser Gly Cys Arg Leu Glu His Pro Ser Ala 
145                 150                 155                 160 


Thr Lys Phe Arg Asn His Val Met Glu Gly Asp Trp Asp Lys Ala Glu 
                165                 170                 175     


Asn Asp Leu Asn Glu Leu Lys Pro Leu Val His Ser Pro His Ala Ile 
            180                 185                 190         


Val Val Arg Gly Ala Leu Glu Ile Ser Gln Thr Leu Leu Gly Ile Ile 
        195                 200                 205             


Val Arg Met Lys Phe Leu Leu Leu Gln Gln Lys Tyr Leu Glu Tyr Leu 
    210                 215                 220                 


Glu Asp Gly Lys Val Leu Glu Ala Leu Gln Val Leu Arg Cys Glu Leu 
225                 230                 235                 240 


Thr Pro Leu Lys Tyr Asn Thr Glu Arg Ile His Val Leu Ser Gly Tyr 
                245                 250                 255     


Leu Met Cys Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu 
            260                 265                 270         


Gly Lys Gly Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr 
        275                 280                 285             


Tyr Leu Pro Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu 
    290                 295                 300                 


Leu Arg Gln Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn 
305                 310                 315                 320 


Thr Lys Leu Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His 
                325                 330                 335     


Val Cys Ser Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr 
            340                 345                 350         


Glu His Cys Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr 
        355                 360                 365             


Lys Leu Ala Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val 
    370                 375                 380                 


Asp Pro Asp Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His 
385                 390                 395                 400 


Ala Tyr Gly Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu 
                405                 410                 415     


Val Ala Cys Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val 
            420                 425                 430         


Gln Thr Gly Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser 
        435                 440                 445             


Leu Thr Ser Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly 
    450                 455                 460                 


Gly Gln Arg Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu 
465                 470                 475                 480 


Asp Ser Trp Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp 
                485                 490                 495     


Gly Lys Thr Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr 
            500                 505                 510         


Asn Phe Glu Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro 
        515                 520                 525             


Ile Met Ser Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn 
    530                 535                 540                 


Val Ala Thr Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu 
545                 550                 555                 560 


Val Arg Lys Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser 
                565                 570                 575     


Cys Phe Gly Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp 
            580                 585                 590         


His Lys Val Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu 
        595                 600                 605             


Leu Thr Gly His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln 
    610                 615                 620                 


Ile Pro Ser Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile 
625                 630                 635                 640 


Trp Gly Pro Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys 
                645                 650                 655     


Ser Ser Met Asp Ser 
            660     


<210>  7371
<211>  4849
<212>  DNA
<213>  Homosapiens

<400>  7371
gctgctgccc ctcccgccgc cgctgctgtc ccccaccgaa gtagcggcca cagcctggtc     60

agcggcagca tcatgcaggc caatggggca ggaggaggag gaggaggtgg cggcggcggc    120

ggtggaggag gagggggcgg cgggggccag ggacagaccc cggaactcgc ctgcttgtcg    180

gcccagaacg gggagtcgtc cccctcgtcg tcgtcgtccg cgggggacct ggcccacgcc    240

aatgggctcc tgccttccgc cccctccgcc gccagcaaca atagcaacag cctgaatgtc    300

aataacgggg ttcccggcgg ggcggccgcc gcatcctcag ccaccgtcgc agctgcctcc    360

gccaccaccg ccgcctcctc ttccttggcc accccagaac tgggcagcag cctcaagaag    420

aagaagcggc tctcccagtc agatgaggat gtcattaggc taataggaca gcacttgaat    480

ggcttagggc tcaaccagac tgttgatctc ctcatgcaag agtcaggatg tcgtttagaa    540

catccttctg ctaccaaatt ccgaaatcat gtcatggaag gagactggga taaggcagaa    600

aatgacctga atgaactaaa gcctttagtg cattctcctc atgctattgt gaggatgaag    660

tttttgctgc tgcagcagaa gtacctagaa tacctggagg atggcaaggt cctggaggca    720

cttcaagttc tacgctgtga attgacgccg ctgaaataca atacagagcg cattcatgtt    780

cttagtgggt atctgatgtg tagccatgca gaagacctac gtgcaaaagc agaatgggaa    840

ggcaaaggga cagcttcccg atctaaacta ttggataaac ttcagaccta tttaccacca    900

tcagtgatgc ttcccccacg gcgtttacag actctcctgc ggcaggcggt ggaactacaa    960

agggatcggt gcctatatca caataccaaa cttgataata atctagattc tgtgtctctg   1020

cttatagacc atgtttgtag taggaggcag ttcccatgtt atacgcagca gatacttacg   1080

gagcattgta atgaagtgtg gttctgtaaa ttctctaatg atggcactaa actagcaaca   1140

ggatcaaaag atacaacagt tatcatatgg caagttgatc cggatacaca cctgctaaaa   1200

ctgcttaaaa cattagaagg acatgcttat ggcgtttctt atattgcatg gagtccagat   1260

gacaactatc ttgttgcttg tggcccagat gactgctctg agctttggct ttggaatgta   1320

caaacaggag aactaaggac aaaaatgagc cagtctcatg aagacagttt gacaagtgtg   1380

gcttggaatc cagatgggaa gcgctttgtg actggaggtc agcgtgggca gttctatcag   1440

tgtgacttag atggtaatct ccttgactcc tgggaagggg taagagtgca atgcctttgg   1500

tgcttgagtg atggaaagac tgttctggca tcagatacac accagcgaat tcggggctat   1560

aacttcgagg accttacaga taggaacata gtacaagaag atcatcctat tatgtctttt   1620

actatttcaa aaaatggccg attagctttg ttaaatgtag caactcaggg agttcattta   1680

tgggacttgc aagacagagt tttagtaaga aagtatcaag gtgttacaca agggttttat   1740

acaattcatt catgttttgg aggccataat gaagacttca tcgctagtgg cagtgaagat   1800

cacaaggttt acatctggca caaacgtagt gaactgccaa ttgcggagct gacagggcac   1860

acacgtacag taaactgtgt gagctggaac ccacagattc catccatgat ggccagcgcc   1920

tcagatgatg gcactgttag aatatgggga ccagcacctt ttatagacca ccagaatatt   1980

gaagaggaat gcagtagcat ggatagttga tggtgaattt ggagcagacg acttctgttt   2040

aacttaaaat tagtcgtatt ttaatggctt gggatttggt gcaaacaaac atgattgata   2100

gctggacaga catgctcgtc atgaaaaaag aaccatttct gaagcccgat tggggccaaa   2160

catttacacc ttgcttcata gtaaccagtt gagatgaagc acgtcgttag aacgttgttg   2220

gacaccatgt tgaattattc ccccatcggt tgtgaagaac tgtgctacat tcaggcttac   2280

ccattgaact cagtatatat atttttttcc ttcctgtctt ttgtctggca ggataccatt   2340

cttgttgctc ttctgtgtaa tgaagtttaa atgcttgttt ggaaaacttt atttaacagt   2400

ttagaaggct tgatagaaag agtgcattag tctgaagagt atacattgga taggaaagaa   2460

tttccttctt ttgtttctcc aaatctttcc gccttattta gcttgagatc tttgcagctt   2520

ggttcatgga ttctagcctt gcccgttgcg cagtatatac tgatccagat gataaaccag   2580

tgaactatgt caaaagcact ctcaatatta catttgacaa aaagttttgt acttttcaca   2640

tagcttgttg ccccgtaaaa gggttaacag cacaattttt taaaaataaa ttaagaagta   2700

tttataggat taaagtgact tcatttgtat acatttggaa tctaaaccag cttaaaaaca   2760

gtttcctcaa tgacttagat acacagtata actgatgctc ttctggaata ccacatgaga   2820

catggtcaga aacagtgctt ggaaggacat tacacaagaa attcagagta atgctttgaa   2880

gatttccccc cttttgtttt attcctgaag gaacatcagt acccgatctt gaagaaattc   2940

aagattcaaa aagaatttta aatacaccaa catgagacat cagtagtcag ttggttttca   3000

gtaaagcttg ttccaagttg ttctcaactt aggaagtaat tttggtgtga tctagcaaaa   3060

gagtaggaat cagcgataca accactttgg aagtttatag tataattgaa attattagaa   3120

gaattcagca ggttacagac atacttaaac tgggattaaa acctcatagt catttttctt   3180

aattgccctt aatattttga catataggga tacataaatt taaagaatat tttttctcag   3240

ttttttcaga tattgccata ctgaacctca ttctaaactg gtgctgtgga tagtctttcc   3300

ctctcccctc ctgttttagt ttaaggaaag gtttccttca tggaaaagca cttttaattt   3360

tgagaatttc acatttaaaa taagccaaaa gcctgatgtt cacattgtgc ttttaaactc   3420

cgtaacagct gaatacaaca taacatagtc tcccttgaaa ttccctccct ttttcagtag   3480

aggataaata gggtgactcc agctgttgga atgagaatgg ggataccccc aaaataagat   3540

tctggtgaag aaaaagtctt gtactaagtt cccctttagg tgtagccaag tctataatat   3600

aattatgatc atgaatagac tccagaatcc acaaagagaa gagggcttgg atgtcaaaaa   3660

ttcttccatt gtggggtagg tggtcgggga tgggagaaag ggaaaagtca gggaagggga   3720

gaagaaagaa aaacacattt ggccttaaaa tagcatgcat tctcccagaa gcccatagta   3780

aagaaaatga cagatcgtgg tcagcagact cttatcaaat tggtatgtaa aagatttctt   3840

caagctccat tttgcagaga ccaccactta gagaatcaaa aaattcctgt tttgatactt   3900

ctaagttaaa atatatgtta cagtttatct ggtacttcat ttttcttaac taaaattact   3960

ttttacttta agcttgaata aaaatcttca ttggtaactg tatgtaatta agtggcaact   4020

tctctttacc tcagtatagt taaaaaccat tcatatttta agtgattcat gtataccctg   4080

aagccgttaa tacaccccag tctctatggt aacatcacta aatgtgggca tagaaactcc   4140

acagctgttt acaaatttgg ttacagtgtg ctacggtgca tttgtaacac tcagatttgt   4200

gcccattcag gggcaatttg gcactcagat tctactctac ttcacctaac cacccctaga   4260

tctgagtttt cagagtgctt ctgaagtaca gtttaaaaac actttttaaa aagtggagta   4320

aaagtgaggc acattttaca agaacataac tcctattaaa acggagtaac aactatgcaa   4380

aggtttctat agcagctagg tgagtttgtt ttccgggtct gtcttaactg gcagcttcct   4440

gtacatactg gtacttattt gctgtaaacg tctgtttcat acatttgcca tgcagtgact   4500

gtgctcgaaa ggtgaaatca atggtaaaga agcctaggat tttatggtat gagaaactga   4560

tcgcaggatt ttctgatcca tagctattaa ttgaaaactt ctgatagtgc tgtaggctct   4620

atagtaggct taagagtgag tcttatacta tgaagccagc cacaagatac taacaaatgt   4680

ataaattgaa aagtaccaat actttttgca catagatcaa aatagagtgg agaatttggg   4740

ctccaaaaat caggttagta ggctcatttc catgtgctta aaaatgtttt tgttgttatg   4800

cattgattaa gggctagagc aaatataaaa ttaaatgtct ttttcctcc               4849


<210>  7372
<211>  645
<212>  PRT
<213>  Homosapiens

<400>  7372

Met Gln Ala Asn Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gln Gly Gln Thr Pro Glu Leu 
            20                  25                  30          


Ala Cys Leu Ser Ala Gln Asn Gly Glu Ser Ser Pro Ser Ser Ser Ser 
        35                  40                  45              


Ser Ala Gly Asp Leu Ala His Ala Asn Gly Leu Leu Pro Ser Ala Pro 
    50                  55                  60                  


Ser Ala Ala Ser Asn Asn Ser Asn Ser Leu Asn Val Asn Asn Gly Val 
65                  70                  75                  80  


Pro Gly Gly Ala Ala Ala Ala Ser Ser Ala Thr Val Ala Ala Ala Ser 
                85                  90                  95      


Ala Thr Thr Ala Ala Ser Ser Ser Leu Ala Thr Pro Glu Leu Gly Ser 
            100                 105                 110         


Ser Leu Lys Lys Lys Lys Arg Leu Ser Gln Ser Asp Glu Asp Val Ile 
        115                 120                 125             


Arg Leu Ile Gly Gln His Leu Asn Gly Leu Gly Leu Asn Gln Thr Val 
    130                 135                 140                 


Asp Leu Leu Met Gln Glu Ser Gly Cys Arg Leu Glu His Pro Ser Ala 
145                 150                 155                 160 


Thr Lys Phe Arg Asn His Val Met Glu Gly Asp Trp Asp Lys Ala Glu 
                165                 170                 175     


Asn Asp Leu Asn Glu Leu Lys Pro Leu Val His Ser Pro His Ala Ile 
            180                 185                 190         


Val Arg Met Lys Phe Leu Leu Leu Gln Gln Lys Tyr Leu Glu Tyr Leu 
        195                 200                 205             


Glu Asp Gly Lys Val Leu Glu Ala Leu Gln Val Leu Arg Cys Glu Leu 
    210                 215                 220                 


Thr Pro Leu Lys Tyr Asn Thr Glu Arg Ile His Val Leu Ser Gly Tyr 
225                 230                 235                 240 


Leu Met Cys Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu 
                245                 250                 255     


Gly Lys Gly Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr 
            260                 265                 270         


Tyr Leu Pro Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu 
        275                 280                 285             


Leu Arg Gln Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn 
    290                 295                 300                 


Thr Lys Leu Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His 
305                 310                 315                 320 


Val Cys Ser Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr 
                325                 330                 335     


Glu His Cys Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr 
            340                 345                 350         


Lys Leu Ala Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val 
        355                 360                 365             


Asp Pro Asp Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His 
    370                 375                 380                 


Ala Tyr Gly Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu 
385                 390                 395                 400 


Val Ala Cys Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val 
                405                 410                 415     


Gln Thr Gly Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser 
            420                 425                 430         


Leu Thr Ser Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly 
        435                 440                 445             


Gly Gln Arg Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu 
    450                 455                 460                 


Asp Ser Trp Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp 
465                 470                 475                 480 


Gly Lys Thr Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr 
                485                 490                 495     


Asn Phe Glu Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro 
            500                 505                 510         


Ile Met Ser Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn 
        515                 520                 525             


Val Ala Thr Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu 
    530                 535                 540                 


Val Arg Lys Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser 
545                 550                 555                 560 


Cys Phe Gly Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp 
                565                 570                 575     


His Lys Val Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu 
            580                 585                 590         


Leu Thr Gly His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln 
        595                 600                 605             


Ile Pro Ser Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile 
    610                 615                 620                 


Trp Gly Pro Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys 
625                 630                 635                 640 


Ser Ser Met Asp Ser 
                645 


<210>  7373
<211>  4962
<212>  DNA
<213>  Homosapiens

<400>  7373
gctgctgccc ctcccgccgc cgctgctgtc ccccaccgaa gtagcggcca cagcctggtc     60

agcggcagca tcatgcaggc caatggggca ggaggaggag gaggaggtgg cggcggcggc    120

ggtggaggag gagggggcgg cgggggccag ggacagaccc cggaactcgc ctgcttgtcg    180

gcccagaacg gggagtcgtc cccctcgtcg tcgtcgtccg cgggggacct ggcccacgcc    240

aatgggctcc tgccttccgc cccctccgcc gccagcaaca atagcaacag cctgaatgtc    300

aataacgggg ttcccggcgg ggcggccgcc gcatcctcag ccaccgtcgc agctgcctcc    360

gccaccaccg ccgcctcctc ttccttggcc accccagaac tgggcagcag cctcaagaag    420

aagaagcggc tctcccagtc agatgaggat gtcattaggc taataggaca gcacttgaat    480

ggcttagggc tcaaccagac tgttgatctc ctcatgcaag agtcaggatg tcgtttagaa    540

catccttctg ctaccaaatt ccgaaatcat gtcatggaag gagactggga taaggcagaa    600

aatgacctga atgaactaaa gcctttagtg cattctcctc atgctattgt ggtaagaggc    660

gcacttgaaa tctctcaaac gttgttggga ataattgtgg cacaaacatt ttctgaaact    720

tccatcaact tttttcccct gactgctgct ttctgtcatg tcagaggatg aagtttttgc    780

tgctgcagca gaagtaccta gaatacctgg aggatggcaa ggtcctggag gcacttcaag    840

ttctacgctg tgaattgacg ccgctgaaat acaatacaga gcgcattcat gttcttagtg    900

ggtatctgat gtgtagccat gcagaagacc tacgtgcaaa agcagaatgg gaaggcaaag    960

ggacagcttc ccgatctaaa ctattggata aacttcagac ctatttacca ccatcagtga   1020

tgcttccccc acggcgttta cagactctcc tgcggcaggc ggtggaacta caaagggatc   1080

ggtgcctata tcacaatacc aaacttgata ataatctaga ttctgtgtct ctgcttatag   1140

accatgtttg tagtaggagg cagttcccat gttatacgca gcagatactt acggagcatt   1200

gtaatgaagt gtggttctgt aaattctcta atgatggcac taaactagca acaggatcaa   1260

aagatacaac agttatcata tggcaagttg atccggatac acacctgcta aaactgctta   1320

aaacattaga aggacatgct tatggcgttt cttatattgc atggagtcca gatgacaact   1380

atcttgttgc ttgtggccca gatgactgct ctgagctttg gctttggaat gtacaaacag   1440

gagaactaag gacaaaaatg agccagtctc atgaagacag tttgacaagt gtggcttgga   1500

atccagatgg gaagcgcttt gtgactggag gtcagcgtgg gcagttctat cagtgtgact   1560

tagatggtaa tctccttgac tcctgggaag gggtaagagt gcaatgcctt tggtgcttga   1620

gtgatggaaa gactgttctg gcatcagata cacaccagcg aattcggggc tataacttcg   1680

aggaccttac agataggaac atagtacaag aagatcatcc tattatgtct tttactattt   1740

caaaaaatgg ccgattagct ttgttaaatg tagcaactca gggagttcat ttatgggact   1800

tgcaagacag agttttagta agaaagtatc aaggtgttac acaagggttt tatacaattc   1860

attcatgttt tggaggccat aatgaagact tcatcgctag tggcagtgaa gatcacaagg   1920

tttacatctg gcacaaacgt agtgaactgc caattgcgga gctgacaggg cacacacgta   1980

cagtaaactg tgtgagctgg aacccacaga ttccatccat gatggccagc gcctcagatg   2040

atggcactgt tagaatatgg ggaccagcac cttttataga ccaccagaat attgaagagg   2100

aatgcagtag catggatagt tgatggtgaa tttggagcag acgacttctg tttaacttaa   2160

aattagtcgt attttaatgg cttgggattt ggtgcaaaca aacatgattg atagctggac   2220

agacatgctc gtcatgaaaa aagaaccatt tctgaagccc gattggggcc aaacatttac   2280

accttgcttc atagtaacca gttgagatga agcacgtcgt tagaacgttg ttggacacca   2340

tgttgaatta ttcccccatc ggttgtgaag aactgtgcta cattcaggct tacccattga   2400

actcagtata tatatttttt tccttcctgt cttttgtctg gcaggatacc attcttgttg   2460

ctcttctgtg taatgaagtt taaatgcttg tttggaaaac tttatttaac agtttagaag   2520

gcttgataga aagagtgcat tagtctgaag agtatacatt ggataggaaa gaatttcctt   2580

cttttgtttc tccaaatctt tccgccttat ttagcttgag atctttgcag cttggttcat   2640

ggattctagc cttgcccgtt gcgcagtata tactgatcca gatgataaac cagtgaacta   2700

tgtcaaaagc actctcaata ttacatttga caaaaagttt tgtacttttc acatagcttg   2760

ttgccccgta aaagggttaa cagcacaatt ttttaaaaat aaattaagaa gtatttatag   2820

gattaaagtg acttcatttg tatacatttg gaatctaaac cagcttaaaa acagtttcct   2880

caatgactta gatacacagt ataactgatg ctcttctgga ataccacatg agacatggtc   2940

agaaacagtg cttggaagga cattacacaa gaaattcaga gtaatgcttt gaagatttcc   3000

ccccttttgt tttattcctg aaggaacatc agtacccgat cttgaagaaa ttcaagattc   3060

aaaaagaatt ttaaatacac caacatgaga catcagtagt cagttggttt tcagtaaagc   3120

ttgttccaag ttgttctcaa cttaggaagt aattttggtg tgatctagca aaagagtagg   3180

aatcagcgat acaaccactt tggaagttta tagtataatt gaaattatta gaagaattca   3240

gcaggttaca gacatactta aactgggatt aaaacctcat agtcattttt cttaattgcc   3300

cttaatattt tgacatatag ggatacataa atttaaagaa tattttttct cagttttttc   3360

agatattgcc atactgaacc tcattctaaa ctggtgctgt ggatagtctt tccctctccc   3420

ctcctgtttt agtttaagga aaggtttcct tcatggaaaa gcacttttaa ttttgagaat   3480

ttcacattta aaataagcca aaagcctgat gttcacattg tgcttttaaa ctccgtaaca   3540

gctgaataca acataacata gtctcccttg aaattccctc cctttttcag tagaggataa   3600

atagggtgac tccagctgtt ggaatgagaa tggggatacc cccaaaataa gattctggtg   3660

aagaaaaagt cttgtactaa gttccccttt aggtgtagcc aagtctataa tataattatg   3720

atcatgaata gactccagaa tccacaaaga gaagagggct tggatgtcaa aaattcttcc   3780

attgtggggt aggtggtcgg ggatgggaga aagggaaaag tcagggaagg ggagaagaaa   3840

gaaaaacaca tttggcctta aaatagcatg cattctccca gaagcccata gtaaagaaaa   3900

tgacagatcg tggtcagcag actcttatca aattggtatg taaaagattt cttcaagctc   3960

cattttgcag agaccaccac ttagagaatc aaaaaattcc tgttttgata cttctaagtt   4020

aaaatatatg ttacagttta tctggtactt catttttctt aactaaaatt actttttact   4080

ttaagcttga ataaaaatct tcattggtaa ctgtatgtaa ttaagtggca acttctcttt   4140

acctcagtat agttaaaaac cattcatatt ttaagtgatt catgtatacc ctgaagccgt   4200

taatacaccc cagtctctat ggtaacatca ctaaatgtgg gcatagaaac tccacagctg   4260

tttacaaatt tggttacagt gtgctacggt gcatttgtaa cactcagatt tgtgcccatt   4320

caggggcaat ttggcactca gattctactc tacttcacct aaccacccct agatctgagt   4380

tttcagagtg cttctgaagt acagtttaaa aacacttttt aaaaagtgga gtaaaagtga   4440

ggcacatttt acaagaacat aactcctatt aaaacggagt aacaactatg caaaggtttc   4500

tatagcagct aggtgagttt gttttccggg tctgtcttaa ctggcagctt cctgtacata   4560

ctggtactta tttgctgtaa acgtctgttt catacatttg ccatgcagtg actgtgctcg   4620

aaaggtgaaa tcaatggtaa agaagcctag gattttatgg tatgagaaac tgatcgcagg   4680

attttctgat ccatagctat taattgaaaa cttctgatag tgctgtaggc tctatagtag   4740

gcttaagagt gagtcttata ctatgaagcc agccacaaga tactaacaaa tgtataaatt   4800

gaaaagtacc aatacttttt gcacatagat caaaatagag tggagaattt gggctccaaa   4860

aatcaggtta gtaggctcat ttccatgtgc ttaaaaatgt ttttgttgtt atgcattgat   4920

taagggctag agcaaatata aaattaaatg tctttttcct cc                      4962


<210>  7374
<211>  451
<212>  PRT
<213>  Homosapiens

<400>  7374

Met Lys Phe Leu Leu Leu Gln Gln Lys Tyr Leu Glu Tyr Leu Glu Asp 
1               5                   10                  15      


Gly Lys Val Leu Glu Ala Leu Gln Val Leu Arg Cys Glu Leu Thr Pro 
            20                  25                  30          


Leu Lys Tyr Asn Thr Glu Arg Ile His Val Leu Ser Gly Tyr Leu Met 
        35                  40                  45              


Cys Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu Gly Lys 
    50                  55                  60                  


Gly Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr Tyr Leu 
65                  70                  75                  80  


Pro Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu Leu Arg 
                85                  90                  95      


Gln Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn Thr Lys 
            100                 105                 110         


Leu Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His Val Cys 
        115                 120                 125             


Ser Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr Glu His 
    130                 135                 140                 


Cys Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr Lys Leu 
145                 150                 155                 160 


Ala Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val Asp Pro 
                165                 170                 175     


Asp Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His Ala Tyr 
            180                 185                 190         


Gly Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu Val Ala 
        195                 200                 205             


Cys Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val Gln Thr 
    210                 215                 220                 


Gly Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser Leu Thr 
225                 230                 235                 240 


Ser Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly Gly Gln 
                245                 250                 255     


Arg Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu Asp Ser 
            260                 265                 270         


Trp Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp Gly Lys 
        275                 280                 285             


Thr Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr Asn Phe 
    290                 295                 300                 


Glu Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro Ile Met 
305                 310                 315                 320 


Ser Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn Val Ala 
                325                 330                 335     


Thr Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu Val Arg 
            340                 345                 350         


Lys Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser Cys Phe 
        355                 360                 365             


Gly Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp His Lys 
    370                 375                 380                 


Val Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu Leu Thr 
385                 390                 395                 400 


Gly His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln Ile Pro 
                405                 410                 415     


Ser Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile Trp Gly 
            420                 425                 430         


Pro Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys Ser Ser 
        435                 440                 445             


Met Asp Ser 
    450     


<210>  7375
<211>  4791
<212>  DNA
<213>  Homosapiens

<400>  7375
gagtggaagt caggaaaggc tcccctgagg aggtttgaaa tgagctgagt cttgaaagac     60

tgactggcat cagacaggtg aagaaaagac gggagagtgt agtcaaagac tctcaaggag    120

aaatgagcca gtacatttgg cggacagtag acaggtccct gaagaggagc aataagagat    180

gaagccaaaa agaaagactg aaagcaacct gtggaaaact acttcagaga aagactttaa    240

atttctgaga aaatctttat acatattgag tatagatgct atcaaccaca tacatgaaaa    300

taattgtttg gggataatgc acaccatttg ccaatgatta agattcagcc cagtctttgt    360

tgctgcattt ctacattcac ataaattgcc agactgttga tctcctcatg caagagtcag    420

gatgtcgttt agaacatcct tctgctacca aattccgaaa tcatgtcatg gaaggagact    480

gggataaggc agaaaatgac ctgaatgaac taaagccttt agtgcattct cctcatgcta    540

ttgtggtaag aggcgcactt gaaatctctc aaacgttgtt gggaataatt gtgaggatga    600

agtttttgct gctgcagcag aagtacctag aatacctgga ggatggcaag gtcctggagg    660

cacttcaagt tctacgctgt gaattgacgc cgctgaaata caatacagag cgcattcatg    720

ttcttagtgg gtatctgatg tgtagccatg cagaagacct acgtgcaaaa gcagaatggg    780

aaggcaaagg gacagcttcc cgatctaaac tattggataa acttcagacc tatttaccac    840

catcagtgat gcttccccca cggcgtttac agactctcct gcggcaggcg gtggaactac    900

aaagggatcg gtgcctatat cacaatacca aacttgataa taatctagat tctgtgtctc    960

tgcttataga ccatgtttgt agtaggaggc agttcccatg ttatacgcag cagatactta   1020

cggagcattg taatgaagtg tggttctgta aattctctaa tgatggcact aaactagcaa   1080

caggatcaaa agatacaaca gttatcatat ggcaagttga tccggataca cacctgctaa   1140

aactgcttaa aacattagaa ggacatgctt atggcgtttc ttatattgca tggagtccag   1200

atgacaacta tcttgttgct tgtggcccag atgactgctc tgagctttgg ctttggaatg   1260

tacaaacagg agaactaagg acaaaaatga gccagtctca tgaagacagt ttgacaagtg   1320

tggcttggaa tccagatggg aagcgctttg tgactggagg tcagcgtggg cagttctatc   1380

agtgtgactt agatggtaat ctccttgact cctgggaagg ggtaagagtg caatgccttt   1440

ggtgcttgag tgatggaaag actgttctgg catcagatac acaccagcga attcggggct   1500

ataacttcga ggaccttaca gataggaaca tagtacaaga agatcatcct attatgtctt   1560

ttactatttc aaaaaatggc cgattagctt tgttaaatgt agcaactcag ggagttcatt   1620

tatgggactt gcaagacaga gttttagtaa gaaagtatca aggtgttaca caagggtttt   1680

atacaattca ttcatgtttt ggaggccata atgaagactt catcgctagt ggcagtgaag   1740

atcacaaggt ttacatctgg cacaaacgta gtgaactgcc aattgcggag ctgacagggc   1800

acacacgtac agtaaactgt gtgagctgga acccacagat tccatccatg atggccagcg   1860

cctcagatga tggcactgtt agaatatggg gaccagcacc ttttatagac caccagaata   1920

ttgaagagga atgcagtagc atggatagtt gatggtgaat ttggagcaga cgacttctgt   1980

ttaacttaaa attagtcgta ttttaatggc ttgggatttg gtgcaaacaa acatgattga   2040

tagctggaca gacatgctcg tcatgaaaaa agaaccattt ctgaagcccg attggggcca   2100

aacatttaca ccttgcttca tagtaaccag ttgagatgaa gcacgtcgtt agaacgttgt   2160

tggacaccat gttgaattat tcccccatcg gttgtgaaga actgtgctac attcaggctt   2220

acccattgaa ctcagtatat atattttttt ccttcctgtc ttttgtctgg caggatacca   2280

ttcttgttgc tcttctgtgt aatgaagttt aaatgcttgt ttggaaaact ttatttaaca   2340

gtttagaagg cttgatagaa agagtgcatt agtctgaaga gtatacattg gataggaaag   2400

aatttccttc ttttgtttct ccaaatcttt ccgccttatt tagcttgaga tctttgcagc   2460

ttggttcatg gattctagcc ttgcccgttg cgcagtatat actgatccag atgataaacc   2520

agtgaactat gtcaaaagca ctctcaatat tacatttgac aaaaagtttt gtacttttca   2580

catagcttgt tgccccgtaa aagggttaac agcacaattt tttaaaaata aattaagaag   2640

tatttatagg attaaagtga cttcatttgt atacatttgg aatctaaacc agcttaaaaa   2700

cagtttcctc aatgacttag atacacagta taactgatgc tcttctggaa taccacatga   2760

gacatggtca gaaacagtgc ttggaaggac attacacaag aaattcagag taatgctttg   2820

aagatttccc cccttttgtt ttattcctga aggaacatca gtacccgatc ttgaagaaat   2880

tcaagattca aaaagaattt taaatacacc aacatgagac atcagtagtc agttggtttt   2940

cagtaaagct tgttccaagt tgttctcaac ttaggaagta attttggtgt gatctagcaa   3000

aagagtagga atcagcgata caaccacttt ggaagtttat agtataattg aaattattag   3060

aagaattcag caggttacag acatacttaa actgggatta aaacctcata gtcatttttc   3120

ttaattgccc ttaatatttt gacatatagg gatacataaa tttaaagaat attttttctc   3180

agttttttca gatattgcca tactgaacct cattctaaac tggtgctgtg gatagtcttt   3240

ccctctcccc tcctgtttta gtttaaggaa aggtttcctt catggaaaag cacttttaat   3300

tttgagaatt tcacatttaa aataagccaa aagcctgatg ttcacattgt gcttttaaac   3360

tccgtaacag ctgaatacaa cataacatag tctcccttga aattccctcc ctttttcagt   3420

agaggataaa tagggtgact ccagctgttg gaatgagaat ggggataccc ccaaaataag   3480

attctggtga agaaaaagtc ttgtactaag ttccccttta ggtgtagcca agtctataat   3540

ataattatga tcatgaatag actccagaat ccacaaagag aagagggctt ggatgtcaaa   3600

aattcttcca ttgtggggta ggtggtcggg gatgggagaa agggaaaagt cagggaaggg   3660

gagaagaaag aaaaacacat ttggccttaa aatagcatgc attctcccag aagcccatag   3720

taaagaaaat gacagatcgt ggtcagcaga ctcttatcaa attggtatgt aaaagatttc   3780

ttcaagctcc attttgcaga gaccaccact tagagaatca aaaaattcct gttttgatac   3840

ttctaagtta aaatatatgt tacagtttat ctggtacttc atttttctta actaaaatta   3900

ctttttactt taagcttgaa taaaaatctt cattggtaac tgtatgtaat taagtggcaa   3960

cttctcttta cctcagtata gttaaaaacc attcatattt taagtgattc atgtataccc   4020

tgaagccgtt aatacacccc agtctctatg gtaacatcac taaatgtggg catagaaact   4080

ccacagctgt ttacaaattt ggttacagtg tgctacggtg catttgtaac actcagattt   4140

gtgcccattc aggggcaatt tggcactcag attctactct acttcaccta accaccccta   4200

gatctgagtt ttcagagtgc ttctgaagta cagtttaaaa acacttttta aaaagtggag   4260

taaaagtgag gcacatttta caagaacata actcctatta aaacggagta acaactatgc   4320

aaaggtttct atagcagcta ggtgagtttg ttttccgggt ctgtcttaac tggcagcttc   4380

ctgtacatac tggtacttat ttgctgtaaa cgtctgtttc atacatttgc catgcagtga   4440

ctgtgctcga aaggtgaaat caatggtaaa gaagcctagg attttatggt atgagaaact   4500

gatcgcagga ttttctgatc catagctatt aattgaaaac ttctgatagt gctgtaggct   4560

ctatagtagg cttaagagtg agtcttatac tatgaagcca gccacaagat actaacaaat   4620

gtataaattg aaaagtacca atactttttg cacatagatc aaaatagagt ggagaatttg   4680

ggctccaaaa atcaggttag taggctcatt tccatgtgct taaaaatgtt tttgttgtta   4740

tgcattgatt aagggctaga gcaaatataa aattaaatgt ctttttcctc c            4791


<210>  7376
<211>  514
<212>  PRT
<213>  Homosapiens

<400>  7376

Met Gln Glu Ser Gly Cys Arg Leu Glu His Pro Ser Ala Thr Lys Phe 
1               5                   10                  15      


Arg Asn His Val Met Glu Gly Asp Trp Asp Lys Ala Glu Asn Asp Leu 
            20                  25                  30          


Asn Glu Leu Lys Pro Leu Val His Ser Pro His Ala Ile Val Val Arg 
        35                  40                  45              


Gly Ala Leu Glu Ile Ser Gln Thr Leu Leu Gly Ile Ile Val Arg Met 
    50                  55                  60                  


Lys Phe Leu Leu Leu Gln Gln Lys Tyr Leu Glu Tyr Leu Glu Asp Gly 
65                  70                  75                  80  


Lys Val Leu Glu Ala Leu Gln Val Leu Arg Cys Glu Leu Thr Pro Leu 
                85                  90                  95      


Lys Tyr Asn Thr Glu Arg Ile His Val Leu Ser Gly Tyr Leu Met Cys 
            100                 105                 110         


Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu Gly Lys Gly 
        115                 120                 125             


Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr Tyr Leu Pro 
    130                 135                 140                 


Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu Leu Arg Gln 
145                 150                 155                 160 


Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn Thr Lys Leu 
                165                 170                 175     


Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His Val Cys Ser 
            180                 185                 190         


Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr Glu His Cys 
        195                 200                 205             


Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr Lys Leu Ala 
    210                 215                 220                 


Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val Asp Pro Asp 
225                 230                 235                 240 


Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His Ala Tyr Gly 
                245                 250                 255     


Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu Val Ala Cys 
            260                 265                 270         


Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val Gln Thr Gly 
        275                 280                 285             


Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser Leu Thr Ser 
    290                 295                 300                 


Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly Gly Gln Arg 
305                 310                 315                 320 


Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu Asp Ser Trp 
                325                 330                 335     


Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp Gly Lys Thr 
            340                 345                 350         


Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr Asn Phe Glu 
        355                 360                 365             


Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro Ile Met Ser 
    370                 375                 380                 


Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn Val Ala Thr 
385                 390                 395                 400 


Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu Val Arg Lys 
                405                 410                 415     


Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser Cys Phe Gly 
            420                 425                 430         


Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp His Lys Val 
        435                 440                 445             


Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu Leu Thr Gly 
    450                 455                 460                 


His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln Ile Pro Ser 
465                 470                 475                 480 


Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile Trp Gly Pro 
                485                 490                 495     


Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys Ser Ser Met 
            500                 505                 510         


Asp Ser 
        


<210>  7377
<211>  4053
<212>  DNA
<213>  Homosapiens

<400>  7377
gctgctgccc ctcccgccgc cgctgctgtc ccccaccgaa gtagcggcca cagcctggtc     60

agcggcagca tcatgcaggc caatggggca ggaggaggag gaggaggtgg cggcggcggc    120

ggtggaggag gagggggcgg cgggggccag ggacagaccc cggaactcgc ctgcttgtcg    180

gcccagaacg gggagtcgtc cccctcgtcg tcgtcgtccg cgggggacct ggcccacgcc    240

aatgggctcc tgccttccgc cccctccgcc gccagcaaca atagcaacag cctgaatgtc    300

aataacgggg ttcccggcgg ggcggccgcc gcatcctcag ccaccgtcgc agctgcctcc    360

gccaccaccg ccgcctcctc ttccttggcc accccagaac tgggcagcag cctcaagaag    420

aagaagcggc tctcccagtc agatgaggat gtcattaggc taataggaca gcacttgaat    480

ggcttagggc tcaaccagac tgttgatctc ctcatgcaag agtcaggatg tcgtttagaa    540

catccttctg ctaccaaatt ccgaaatcat gtcatggaag gagactggga taaggcagaa    600

aatgacctga atgaactaaa gcctttagtg cattctcctc atgctattgt ggtaagaggc    660

gcacttgaaa tctctcaaac gttgttggga ataattgtga ggatgaagtt tttgctgctg    720

cagcagaagt acctagaata cctggaggat ggcaaggtcc tggaggcact tcaagttcta    780

cgctgtgaat tgacgccgct gaaatacaat acagagcgca ttcatgttct tagtgggtat    840

ctgatgtgta gccatgcaga agacctacgt gcaaaagcag aatgggaagg caaagggaca    900

gcttcccgat ctaaactatt ggataaactt cagacctatt taccaccatc agtgatgctt    960

cccccacggc gtttacagac tctcctgcgg caggcggtgg aactacaaag ggatcggtgc   1020

ctatatcaca ataccaaact tgataataat ctagattctg tgtctctgct tatagaccat   1080

gtttgtagta ggaggcagtt cccatgttat acgcagcaga tacttacgga gcattgtaat   1140

gaagtgtggt tctgtaaatt ctctaatgat ggcactaaac tagcaacagg atcaaaagat   1200

acaacagtta tcatatggca agttgatccg gatacacacc tgctaaaact gcttaaaaca   1260

ttagaaggac atgcttatgg cgtttcttat attgcatgga gtccagatga caactatctt   1320

gttgcttgtg gcccagatga ctgctctgag ctttggcttt ggaatgtaca aacaggagaa   1380

ctaaggacaa aaatgagcca gtctcatgaa gacagtttga caagtgtggc ttggaatcca   1440

gatgggaagc gctttgtgac tggaggtcag cgtgggcagt tctatcagtg tgacttagat   1500

ggtaatctcc ttgactcctg ggaaggggta agagtgcaat gcctttggtg cttgagtgat   1560

ggaaagactg ttctggcatc agatacacac cagcgaattc ggggctataa cttcgaggac   1620

cttacagata ggaacatagt acaagaagat catcctatta tgtcttttac tatttcaaaa   1680

aatggccgat tagctttgtt aaatgtagca actcagggag ttcatttatg ggacttgcaa   1740

gacagagttt tagtaagaaa gtatcaaggt gttacacaag ggttttatac aattcattca   1800

tgttttggag gccataatga agacttcatc gctagtggca gtgaagatca caaggtttac   1860

atctggcaca aacgtagtga actgccaatt gcggagctga cagggcacac acgtacagta   1920

aactgtgtga gctggaaccc acagattcca tccatgatgg ccagcgcctc agatgatggc   1980

actgttagaa tatggggacc agcacctttt atagaccacc agaatattga agaggaatgc   2040

agtagcatgg atagttgatg gtgaatttgg agcagacgac ttctgtttaa cttaaaatta   2100

gtcgtatttt aatggcttgg gatttggtgc aaacaaacat gattgatagc tggacagaca   2160

tgctcgtcat gaaaaaagaa ccatttctga agcccgattg gggccaaaca tttacacctt   2220

gcttcatagt aaccagttga gatgaagcac gtcgttagaa cgttgttgga caccatgttg   2280

aattattccc ccatcggttg tgaagaactg tgctacattc aggcttaccc attgaactca   2340

gtatatatat ttttttcctt cctgtctttt gtctggcagg ataccattct tgttgctctt   2400

ctgtgtaatg aagtttaaat gcttgtttgg aaaactttat ttaacagttt agaaggcttg   2460

atagaaagag tgcattagtc tgaagagtat acattggata ggaaagaatt tccttctttt   2520

gtttctccaa atctttccgc cttatttagc ttgagatctt tgcagcttgg ttcatggatt   2580

ctagccttgc ccgttgcgca gtatatactg atccagatga taaaccagtg aactatgtca   2640

aaagcactct caatattaca tttgacaaaa agttttgtac ttttcacata gcttgttgcc   2700

ccgtaaaagg gttaacagca caatttttta aaaataaatt aagaagtatt tataggatta   2760

aagtgacttc atttgtatac atttggaatc taaaccagct taaaaacagt ttcctcaatg   2820

acttagatac acagtataac tgatgctctt ctggaatacc acatgagaca tggtcagaaa   2880

cagtgcttgg aaggacatta cacaagaaat tcagagtaat gctttgaaga tttcccccct   2940

tttgttttat tcctgaagga acatcagtac ccgatcttga agaaattcaa gattcaaaaa   3000

gaattttaaa tacaccaaca tgagacatca gtagtcagtt ggttttcagt aaagcttgtt   3060

ccaagttgtt ctcaacttag gaagtaattt tggtgtgatc tagcaaaaga gtaggaatca   3120

gcgatacaac cactttggaa gtttatagta taattgaaat tattagaaga attcagcagg   3180

ttacagacat acttaaactg ggattaaaac ctcatagtca tttttcttaa ttgcccttaa   3240

tattttgaca tatagggata cataaattta aagaatattt tttctcagtt ttttcagata   3300

ttgccatact gaacctcatt ctaaactggt gctgtggata gtctttccct ctcccctcct   3360

gttttagttt aaggaaaggt ttccttcatg gaaaagcact tttaattttg agaatttcac   3420

atttaaaata agccaaaagc ctgatgttca cattgtgctt ttaaactccg taacagctga   3480

atacaacata acatagtctc ccttgaaatt ccctcccttt ttcagtagag gataaatagg   3540

gtgactccag ctgttggaat gagaatgggg atacccccaa aataagattc tggtgaagaa   3600

aaagtcttgt actaagttcc cctttaggtg tagccaagtc tataatataa ttatgatcat   3660

gaatagactc cagaatccac aaagagaaga gggcttggat gtcaaaaatt cttccattgt   3720

ggggtaggtg gtcggggatg ggagaaaggg aaaagtcagg gaaggggaga agaaagaaaa   3780

acacatttgg ccttaaaata gcatgcattc tcccagaagc ccatagtaaa gaaaatgaca   3840

gatcgtggtc agcagactct tatcaaattg gtatgtaaaa gatttcttca agctccattt   3900

tgcagagacc accacttaga gaatcaaaaa attcctgttt tgatacttct aagttaaaat   3960

atatgttaca gtttatctgg tacttcattt ttcttaacta aaattacttt ttactttaag   4020

cttgaataaa aatcttcatt ggtaactgta tgt                                4053


<210>  7378
<211>  661
<212>  PRT
<213>  Homosapiens

<400>  7378

Met Gln Ala Asn Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gln Gly Gln Thr Pro Glu Leu 
            20                  25                  30          


Ala Cys Leu Ser Ala Gln Asn Gly Glu Ser Ser Pro Ser Ser Ser Ser 
        35                  40                  45              


Ser Ala Gly Asp Leu Ala His Ala Asn Gly Leu Leu Pro Ser Ala Pro 
    50                  55                  60                  


Ser Ala Ala Ser Asn Asn Ser Asn Ser Leu Asn Val Asn Asn Gly Val 
65                  70                  75                  80  


Pro Gly Gly Ala Ala Ala Ala Ser Ser Ala Thr Val Ala Ala Ala Ser 
                85                  90                  95      


Ala Thr Thr Ala Ala Ser Ser Ser Leu Ala Thr Pro Glu Leu Gly Ser 
            100                 105                 110         


Ser Leu Lys Lys Lys Lys Arg Leu Ser Gln Ser Asp Glu Asp Val Ile 
        115                 120                 125             


Arg Leu Ile Gly Gln His Leu Asn Gly Leu Gly Leu Asn Gln Thr Val 
    130                 135                 140                 


Asp Leu Leu Met Gln Glu Ser Gly Cys Arg Leu Glu His Pro Ser Ala 
145                 150                 155                 160 


Thr Lys Phe Arg Asn His Val Met Glu Gly Asp Trp Asp Lys Ala Glu 
                165                 170                 175     


Asn Asp Leu Asn Glu Leu Lys Pro Leu Val His Ser Pro His Ala Ile 
            180                 185                 190         


Val Val Arg Gly Ala Leu Glu Ile Ser Gln Thr Leu Leu Gly Ile Ile 
        195                 200                 205             


Val Arg Met Lys Phe Leu Leu Leu Gln Gln Lys Tyr Leu Glu Tyr Leu 
    210                 215                 220                 


Glu Asp Gly Lys Val Leu Glu Ala Leu Gln Val Leu Arg Cys Glu Leu 
225                 230                 235                 240 


Thr Pro Leu Lys Tyr Asn Thr Glu Arg Ile His Val Leu Ser Gly Tyr 
                245                 250                 255     


Leu Met Cys Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu 
            260                 265                 270         


Gly Lys Gly Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr 
        275                 280                 285             


Tyr Leu Pro Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu 
    290                 295                 300                 


Leu Arg Gln Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn 
305                 310                 315                 320 


Thr Lys Leu Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His 
                325                 330                 335     


Val Cys Ser Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr 
            340                 345                 350         


Glu His Cys Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr 
        355                 360                 365             


Lys Leu Ala Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val 
    370                 375                 380                 


Asp Pro Asp Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His 
385                 390                 395                 400 


Ala Tyr Gly Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu 
                405                 410                 415     


Val Ala Cys Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val 
            420                 425                 430         


Gln Thr Gly Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser 
        435                 440                 445             


Leu Thr Ser Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly 
    450                 455                 460                 


Gly Gln Arg Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu 
465                 470                 475                 480 


Asp Ser Trp Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp 
                485                 490                 495     


Gly Lys Thr Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr 
            500                 505                 510         


Asn Phe Glu Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro 
        515                 520                 525             


Ile Met Ser Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn 
    530                 535                 540                 


Val Ala Thr Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu 
545                 550                 555                 560 


Val Arg Lys Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser 
                565                 570                 575     


Cys Phe Gly Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp 
            580                 585                 590         


His Lys Val Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu 
        595                 600                 605             


Leu Thr Gly His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln 
    610                 615                 620                 


Ile Pro Ser Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile 
625                 630                 635                 640 


Trp Gly Pro Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys 
                645                 650                 655     


Ser Ser Met Asp Ser 
            660     


<210>  7379
<211>  2965
<212>  DNA
<213>  Homosapiens

<400>  7379
gctgctgccc ctcccgccgc cgctgctgtc ccccaccgaa gtagcggcca cagcctggtc     60

agcggcagca tcatgcaggc caatggggca ggaggaggag gaggaggtgg cggcggcggc    120

ggtggaggag gagggggcgg cgggggccag ggacagaccc cggaactcgc ctgcttgtcg    180

gcccagaacg gggagtcgtc cccctcgtcg tcgtcgtccg cgggggacct ggcccacgcc    240

aatgggctcc tgccttccgc cccctccgcc gccagcaaca atagcaacag cctgaatgtc    300

aataacgggg ttcccggcgg ggcggccgcc gcatcctcag ccaccgtcgc agctgcctcc    360

gccaccaccg ccgcctcctc ttccttggcc accccagaac tgggcagcag cctcaagaag    420

aagaagcggc tctcccagtc agatgaggat gtcattaggc taataggaca gcacttgaat    480

ggcttagggc tcaaccagac tgttgatctc ctcatgcaag agtcaggatg tcgtttagaa    540

catccttctg ctaccaaatt ccgaaatcat gtcatggaag gagactggga taaggcagaa    600

aatgacctga atgaactaaa gcctttagtg cattctcctc atgctattgt ggcacaaaca    660

ttttctgaaa cttccatcaa cttttttccc ctgactgctg ctttctgtca tgtcagagga    720

tgaagttttt gctgctgcag cagaagtacc tagaatacct ggaggatggc aaggtcctgg    780

aggcacttca agttctacgc tgtgaattga cgccgctgaa atacaataca gagcgcattc    840

atgttcttag tgggtatctg atgtgtagcc atgcagaaga cctacgtgca aaagcagaat    900

gggaaggcaa agggacagct tcccgatcta aactattgga taaacttcag acctatttac    960

caccatcagt gatgcttccc ccacggcgtt tacagactct cctgcggcag gcggtggaac   1020

tacaaaggga tcggtgccta tatcacaata ccaaacttga taataatcta gattctgtgt   1080

ctctgcttat agaccatgtt tgtagtagac tggtgaattg acaaaatgta attctaaatt   1140

attgattggg aaaagaagca aggaagaccg tgtttcaaga tacacttaaa ggaggcagtt   1200

cccatgttat acgcagcaga tacttacgga gcattgtaat gaagtgtggt tctgtaaatt   1260

ctctaatgat ggcactaaac tagcaacagg atcaaaagat acaacagtta tcatatggca   1320

agttgatccg gatacacacc tgctaaaact gcttaaaaca ttagaaggac atgcttatgg   1380

cgtttcttat attgcatgga gtccagatga caactatctt gttgcttgtg gcccagatga   1440

ctgctctgag ctttggcttt ggaatgtaca agaaaactat ccccatgtac cttttattat   1500

tacaccaagg gcagctatta tctctcagat cctgtttcta atccatgaac aaaatggaat   1560

caagactaga ttaaatgaca ggagaactaa ggacaaaaat gagccagtct catgaagaca   1620

gtttgacaag tgtggcttgg aatccagatg ggaagcgctt tgtgactgga ggtcagcgtg   1680

ggcagttcta tcagtgtgac ttagatggta atctccttga ctcctgggaa ggggtaagag   1740

tgcaatgcct ttggtgcttg agtgatggaa agactgttct ggcatcagat acacaccagc   1800

gaattcgggg ctataacttc gaggacctta cagataggaa catagtacaa gaagatcatc   1860

ctattatgtc ttttactatt tcaaaaaatg gccgattagc tttgttaaat gtagcaactc   1920

agggagttca tttatgggac ttgcaagaca gagttttagt aagaaagtat caaggtgtta   1980

cacaagggtt ttatacaatt cattcatgtt ttggaggcca taatgaagac ttcatcgcta   2040

gtggcagtga agatcacaag gtttacatct ggcacaaacg tagtgaactg ccaattgcgg   2100

agctgacagg gcacacacgt acagtaaact gtgtgagctg gaacccacag attccatcca   2160

tgatggccag cgcctcagat gatggcactg ttagaatatg gggaccagca ccttttatag   2220

accaccagaa tattgaagag gaatgcagta gcatggatag ttgatggtga atttggagca   2280

gacgacttct gtttaactta aaattagtcg tattttaatg gcttgggatt tggtgcaaac   2340

aaacatgatt gatagctgga cagacatgct cgtcatgaaa aaagaaccat ttctgaagcc   2400

cgattggggc caaacattta caccttgctt catagtaacc agttgagatg aagcacgtcg   2460

ttagaacgtt gttggacacc atgttgaatt attcccccat cggttgtgaa gaactgtgct   2520

acattcaggc ttacccattg aactcagtat atatattttt ttccttcctg tcttttgtct   2580

ggcaggatac cattcttgtt gctcttctgt gtaatgaagt ttaaatgctt gtttggaaaa   2640

ctttatttaa cagtttagaa ggcttgatag aaagagtgca ttagtctgaa gagtatacat   2700

tggataggaa agaatttcct tcttttgttt ctccaaatct ttccgcctta tttagcttga   2760

gatctttgca gcttggttca tggattctag ccttgcccgt tgcgcagtat atactgatcc   2820

agatgataaa ccagtgaact atgtcaaaag cactctcaat attacatttg acaaaaagtt   2880

ttgtactttt cacatagctt gttgccccgt aaaagggtta acagcacaat tttttaaaaa   2940

taaattaaga agtatttata ggatt                                         2965


<210>  7380
<211>  229
<212>  PRT
<213>  Homosapiens

<400>  7380

Met Thr Gly Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser 
1               5                   10                  15      


Leu Thr Ser Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly 
            20                  25                  30          


Gly Gln Arg Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu 
        35                  40                  45              


Asp Ser Trp Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp 
    50                  55                  60                  


Gly Lys Thr Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr 
65                  70                  75                  80  


Asn Phe Glu Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro 
                85                  90                  95      


Ile Met Ser Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn 
            100                 105                 110         


Val Ala Thr Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu 
        115                 120                 125             


Val Arg Lys Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser 
    130                 135                 140                 


Cys Phe Gly Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp 
145                 150                 155                 160 


His Lys Val Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu 
                165                 170                 175     


Leu Thr Gly His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln 
            180                 185                 190         


Ile Pro Ser Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile 
        195                 200                 205             


Trp Gly Pro Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys 
    210                 215                 220                 


Ser Ser Met Asp Ser 
225                 


<210>  7381
<211>  2118
<212>  DNA
<213>  Homosapiens

<400>  7381
tgaggtgtgc tgctgtgctg ggttaacagc ttccttccct ttctgtgtag cagtcttgaa     60

atgttctgtt taaatcagta ggcttaatgt gttctgggta tttatctcct tgtattttaa    120

atatatgtag ttgcaaatag caccaggaat tagatttctg tacaccccta atctagcctt    180

gtgagcttcg ctagttaatg tgtgctcact ttccctccat ttgttacgtg agagaatgcg    240

tctgctgatc actgaagtgt cccttttagc ttctgattca ttgggttctg ttgggcatct    300

ttaaatccac cttaacctga ggaatgtatg tgggcaacca ggccctgcat ttttttatat    360

tctgaatttt gcatgcttgc ctgacttagt atttctgaat tgatgttttt tttaatggta    420

taactatctt gattttcact gaaattatat ggttctgtca ctactctgta aattaatccg    480

aaacttttaa ggtaactggg atgatctgct tgtaaaaatg cttgttgcct tttgctttat    540

cttcagtgta cctccttaat cctgcttcaa cttgattatc ttgtgaaacg atgagagtaa    600

gttgcaacct tgtgactgaa aacttgaaaa gagtggagca ggtgggacct cttattctca    660

aatagtgaca tattctccgt agtcacagtt tcagaactga gtaaggatcc ttggtacttg    720

gtggcatctg ttgaactgag gagcatttct cattgtaaag attgcctttg ttctgtctaa    780

aagtctggag aaatcccaaa gacttttcct atgtactagg cattttattt tgattgactt    840

acaaactctt cttaatcatt atcaatctcg gtttttttgt ggtgcagtgg aaggagaaat    900

aggtctagtt tctgcctctg attagccgca cagccttgaa caaatcacat ttcatctttg    960

aacttacctc tactgttaga ctaggcgact cacatttgag gacttttctc gggtatcttg   1020

agggtttgtg atcctgaacc cttaaacagt gcttttttgt tacacaggag ggcttttttg   1080

gggggatgac cagtacagac atgccagtta gttttactag tgggatccca aatccaaagc   1140

agtgtagtgg tgattggtca gtgactaacc aggcagagct taagtttggg gagggtagaa   1200

acgccgtttc cttgggaact ggagtgcagt atgagctggg tgtcacttgg ctctgaacat   1260

actggctttg ctgtaatgct tgaaaaggcg ttggtatctt cattttacag ttcattaacc   1320

caagtacgtt ttcttattta aatgacaact ttggtgcttt aaaatgaggt accacttttt   1380

aaagctagct gtgtcgagtt aaagaaaaaa tcagcagttt tttctcccag aaatgtaatt   1440

gccaaacact attcatcccc atcttaagtt ttacaaggtg atgtaatcag cttgttgtag   1500

tgatgctggc caaatggtgc tcagcaggtg agaacaaaaa aaccccagat ctcagtgaac   1560

taatacacag cttgagcgtt tccatgtgct aatgttgcac acttactaaa aaactttgga   1620

aatggaaaat aatgtattag tgcaacagtt gatgtgcttc tttgggcaaa gatatagttt   1680

tgttccacaa tttgtactta aaagcgaaag aacattgaaa acatagactt actggctgta   1740

gcaatgctgg cctgttaact gataactaga acttaggttc acgtttatgt aaagtgtgta   1800

aaacctagta gagcttgcat agtcggcact cagtaaatgt ttggttcctt ttgccccttg   1860

gtaagtttat tttaccatcc tcccacctgc cattctgact ttattaaatc aacatgtgga   1920

ccagagtgtt aatgagatgt tattgcagaa gagattgaga aaattggtat atcatgcaga   1980

taacatacaa aatctttttg taacgtaaaa aatgcagttt tattattgct tgtgcctcaa   2040

ctgtttaagt gaatattaaa gggcttggag aaaactttgg cttggcgtat gtttggagaa   2100

gtgaactctg ctgaattt                                                 2118


<210>  7382
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  7382

Met Thr Ser Thr Asp Met Pro Val Ser Phe Thr Ser Gly Ile Pro Asn 
1               5                   10                  15      


Pro Lys Gln Cys Ser Gly Asp Trp Ser Val Thr Asn Gln Ala Glu Leu 
            20                  25                  30          


Lys Phe Gly Glu Gly Arg Asn Ala Val Ser Leu Gly Thr Gly Val Gln 
        35                  40                  45              


Tyr Glu Leu Gly Val Thr Trp Leu 
    50                  55      


<210>  7383
<211>  3401
<212>  DNA
<213>  Homosapiens

<400>  7383
cctctgctca ggctctgccg cggacgacct cgaggccctt agttgactgg gaccggaagt     60

ggcgtgtgct cggcctttct gtgttcctgg cccgcggccg tcgggtgtga gctgcgccga    120

ccgctctgag ggttcgtggc ccaccgctcc ttcgcggtcc ctgccgccac cgtccacgct    180

cagcgttgta gagaagatgg tgggtcggaa cagcgccatc gccgccggtg tatgcggggc    240

ccttttcatt gggtactgca tctacttcga ccgcaaaaga cgaagtgacc ccaacttcaa    300

gaacaggctt cgagaacgaa gaaagaaaca gaagcttgcc aaggagagag ctgggctttc    360

caagttacct gaccttaaag atgctgaagc tgttcagaag ttcttccttg aagaaataca    420

gcttggtgaa gagttactag ctcaaggtga atatgagaag ggcgtagacc atctgacaaa    480

tgcaattgct gtgtgtggac agccacagca gttactgcag gtcttacagc aaactcttcc    540

accaccagtg ttccagatgc ttctgactaa gctcccaaca attagtcaga gaattgtaag    600

tgctcagagc ttggctgaag atgatgtgga atgagaaaca aatgtcaaca taataaaatc    660

tcagttaaaa atattttaaa aattcttggt agttgagcag ctctggggga ataagggcaa    720

atatgcttgt tatgaactac actgaaatct accaaagtta atgtttactt tgtgtagatc    780

catttgtcta ttttatttat ttttcccagt gaaaagtgta ttttgataga gaacttttca    840

ttctataaat acactatgag ttactaaaat atcatggatt ttgtttattc ctgaaacata    900

gttacatagt taaactgtac atatgacatg gcttatgtta aaaataccca gtgctcagtt    960

ttgaaagata ggcaaaaaaa aaaaagtata ggagaaactg aagaatgtac acttttttag   1020

agggcacatt ttgctgtaaa tctggaaatt tgatagactt gactgtgttt gtgaaaactg   1080

agcattaaag gttttgattg atcctttctt tccatttaat ctctgagacg taaatatgtg   1140

aggtgtgctg ctgtgctggg ttaacagctt ccttcccttt ctgtgtagca gtcttgaaat   1200

gttctgttta aatcagtagg cttaatgtgt tctgggtatt tatctccttg tattttaaat   1260

atatgtagtt gcaaatagca ccaggaatta gatttctgta cacccctaat ctagccttgt   1320

gagcttcgct agttaatgtg tgctcacttt ccctccattt gttacgtgag agaatgcgtc   1380

tgctgatcac tgaagtgtcc cttttagctt ctgattcatt gggttctgtt gggcatcttt   1440

aaatccacct taacctgagg aatgtatgtg ggcaaccagg ccctgcattt ttttatattc   1500

tgaattttgc atgcttgcct gacttagtat ttctgaattg atgttttttt taatggtata   1560

actatcttga ttttcactga aattatatgg ttctgtcact actctgtaaa ttaatccgaa   1620

acttttaagg taactgggat gatctgcttg taaaaatgct tgttgccttt tgctttatct   1680

tcagtgtacc tccttaatcc tgcttcaact tgattatctt gtgaaacgat gagagtaagt   1740

tgcaaccttg tgactgaaaa cttgaaaaga gtggagcagg tgggacctct tattctcaaa   1800

tagtgacata ttctccgtag tcacagtttc agaactgagt aaggatcctt ggtacttggt   1860

ggcatctgtt gaactgagga gcatttctca ttgtaaagat tgcctttgtt ctgtctaaaa   1920

gtctggagaa atcccaaaga cttttcctat gtactaggca ttttattttg attgacttac   1980

aaactcttct taatcattat caatctcggt ttttttgtgg tgcagtggaa ggagaaatag   2040

gtctagtttc tgcctctgat tagccgcaca gccttgaaca aatcacattt catctttgaa   2100

cttacctcta ctgttagact aggcgactca catttgagga cttttctcgg gtatcttgag   2160

ggtttgtgat cctgaaccct taaacagtgc ttttttgtta cacaggaggg cttttttggg   2220

gggatgacca gtacagacat gccagttagt tttactagtg ggatcccaaa tccaaagcag   2280

tgtagtggtg attggtcagt gactaaccag gcagctaaga agtcttaggc agcagcccag   2340

acatgtatag aggggcagtt agagggagaa caggggtggg aaagggagca aggggcagat   2400

agctcagcaa ggaaagaatg ggctcagaaa aaggagggct ggctggagga gtgaggggca   2460

gcttaagttt ggggagggta gaaacgccgt ttccttggga actggagtgc agtatgagct   2520

gggtgtcact tggctctgaa catactggct ttgctgtaat gcttgaaaag gcgttggtat   2580

cttcatttta cagttcatta acccaagtac gttttcttat ttaaatgaca actttggtgc   2640

tttaaaatga ggtaccactt tttaaagcta gctgtgtcga gttaaagaaa aaatcagcag   2700

ttttttctcc cagaaatgta attgccaaac actattcatc cccatcttaa gttttacaag   2760

gtgatgtaat cagcttgttg tagtgatgct ggccaaatgg tgctcagcag gtgagaacaa   2820

aaaaacccca gatctcagtg aactaataca cagcttgagc gtttccatgt gctaatgttg   2880

cacacttact aaaaaacttt ggaaatggaa aataatgtat tagtgcaaca gttgatgtgc   2940

ttctttgggc aaagatatag ttttgttcca caatttgtac ttaaaagcga aagaacattg   3000

aaaacataga cttactggct gtagcaatgc tggcctgtta actgataact agaacttagg   3060

ttcacgttta tgtaaagtgt gtaaaaccta gtagagcttg catagtcggc actcagtaaa   3120

tgtttggttc cttttgcccc ttggtaagtt tattttacca tcctcccacc tgccattctg   3180

actttattaa atcaacatgt ggaccagagt gttaatgaga tgttattgca gaagagattg   3240

agaaaattgg tatatcatgc agataacata caaaatcttt ttgtaacgta aaaaatgcag   3300

ttttattatt gcttgtgcct caactgttta agtgaatatt aaagggcttg gagaaaactt   3360

tggcttggcg tatgtttgga gaagtgaact ctgctgaatt t                       3401


<210>  7384
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  7384

Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala Leu 
1               5                   10                  15      


Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Lys Arg Arg Ser Asp Pro 
            20                  25                  30          


Asn Phe Lys Asn Arg Leu Arg Glu Arg Arg Lys Lys Gln Lys Leu Ala 
        35                  40                  45              


Lys Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu 
    50                  55                  60                  


Ala Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Leu Ala Gln Gly Glu Tyr Glu Lys Gly Val Asp His Leu Thr Asn Ala 
                85                  90                  95      


Ile Ala Val Cys Gly Gln Pro Gln Gln Leu Leu Gln Val Leu Gln Gln 
            100                 105                 110         


Thr Leu Pro Pro Pro Val Phe Gln Met Leu Leu Thr Lys Leu Pro Thr 
        115                 120                 125             


Ile Ser Gln Arg Ile Val Ser Ala Gln Ser Leu Ala Glu Asp Asp Val 
    130                 135                 140                 


Glu 
145 


<210>  7385
<211>  2079
<212>  DNA
<213>  Homosapiens

<400>  7385
tgaggtgtgc tgctgtgctg ggttaacagc ttccttccct ttctgtgtag cagtcttgaa     60

atgttctgtt taaatcagta ggcttaatgt gttctgggta tttatctcct tgtattttaa    120

atatatgtag ttgcaaatag caccaggaat tagatttctg tacaccccta atctagcctt    180

gtgagcttcg ctagttaatg tgtgctcact ttccctccat ttgttacgtg agagaatgcg    240

tctgctgatc actgaagtgt cccttttagc ttctgattca ttgggttctg ttgggcatct    300

ttaaatccac cttaacctga ggaatgtatg tgggcaacca ggccctgcat ttttttatat    360

tctgaatttt gcatgcttgc ctgacttagt atttctgaat tgatgttttt tttaatggta    420

taactatctt gattttcact gaaattatat ggttctgtca ctactctgta aattaatccg    480

aaacttttaa ggtaactggg atgatctgct tgtaaaaatg cttgttgcct tttgctttat    540

cttcagtgta cctccttaat cctgcttcaa cttgattatc ttgtgaaacg atgagagtaa    600

gttgcaacct tgtgactgaa aacttgaaaa gagtggagca ggtgggacct cttattctca    660

aatagtgaca tattctccgt agtcacagtt tcagaactga gtaaggatcc ttggtacttg    720

gtggcatctg ttgaactgag gagcatttct cattgtaaag attgcctttg ttctgtctaa    780

aagtctggag aaatcccaaa gacttttcct atgtactagg cattttattt tgattgactt    840

acaaactctt cttaatcatt atcaatctcg gtttttttgt ggtgcagtgg aaggagaaat    900

aggtctagtt tctgcctctg attagccgca cagccttgaa caaatcacat ttcatctttg    960

aacttacctc tactgttaga ctaggcgact cacatttgag gacttttctc gggtatcttg   1020

agggtttgtg atcctgaacc cttaaacagt gcttttttgt tacacaggag ggcttttttg   1080

gggggatgac cagtacagac atgccagtta gttttactag tgggatccca aatccaaagc   1140

agtgtagtgg tgattggtca gtgactaacc aggcagagct taagtttggg gagggtagaa   1200

acgccgtttc cttgggaact ggagtgcagt atgagctggg tgtcacttgg ctctgaacat   1260

actggctttg ctgtaatgct tgaaaaggcg ttggtatctt cattttacag ttcattaacc   1320

caagtacgtt ttcttattta aatgacaact ttggtgcttt aaaatgaggt accacttttt   1380

aaagctagct gtgtcgagtt aaagaaaaaa tcagcagttt tttctcccag aaatgtaatt   1440

gccaaacact attcatcccc atcttaagtt ttacaaggtg atgtaatcag cttgttgtag   1500

tgatgctggc caaatggtgc tcagcaggtg agaacaaaaa aaccccagat ctcagtgaac   1560

taatacacag cttgagcgtt tccatgtgct aatgttgcac acttactaaa aaactttgga   1620

aatggaaaat aatgtattag tgcaacagtt gatgtgcttc tttgggcaaa gatatagttt   1680

tgttccacaa tttgtactta aaagcgaaag aacattgaaa acatagactt actggctgta   1740

gcaatgctgg cctgttaact gataactaga acttaggttc acgtttatgt aaagtgtgta   1800

aaacctagta gagcttgcat agtcggcact cagtaaatgt ttggttcctt ttgccccttg   1860

gtaagtttat tttaccatcc tcccacctgc cattctgact ttattaaatc aacatgtgga   1920

ccagagtgtt aatgagatgt tattgcagaa gagattgaga aaattggtat atcatgcaga   1980

taacatacaa aatctttttg taacgtaaaa aatgcagttt tattattgct tgtgcctcaa   2040

ctgtttaagt gaatattaaa gggcttggag aaaactttg                          2079


<210>  7386
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  7386

Met Thr Ser Thr Asp Met Pro Val Ser Phe Thr Ser Gly Ile Pro Asn 
1               5                   10                  15      


Pro Lys Gln Cys Ser Gly Asp Trp Ser Val Thr Asn Gln Ala Glu Leu 
            20                  25                  30          


Lys Phe Gly Glu Gly Arg Asn Ala Val Ser Leu Gly Thr Gly Val Gln 
        35                  40                  45              


Tyr Glu Leu Gly Val Thr Trp Leu 
    50                  55      


<210>  7387
<211>  3362
<212>  DNA
<213>  Homosapiens

<400>  7387
cctctgctca ggctctgccg cggacgacct cgaggccctt agttgactgg gaccggaagt     60

ggcgtgtgct cggcctttct gtgttcctgg cccgcggccg tcgggtgtga gctgcgccga    120

ccgctctgag ggttcgtggc ccaccgctcc ttcgcggtcc ctgccgccac cgtccacgct    180

cagcgttgta gagaagatgg tgggtcggaa cagcgccatc gccgccggtg tatgcggggc    240

ccttttcatt gggtactgca tctacttcga ccgcaaaaga cgaagtgacc ccaacttcaa    300

gaacaggctt cgagaacgaa gaaagaaaca gaagcttgcc aaggagagag ctgggctttc    360

caagttacct gaccttaaag atgctgaagc tgttcagaag ttcttccttg aagaaataca    420

gcttggtgaa gagttactag ctcaaggtga atatgagaag ggcgtagacc atctgacaaa    480

tgcaattgct gtgtgtggac agccacagca gttactgcag gtcttacagc aaactcttcc    540

accaccagtg ttccagatgc ttctgactaa gctcccaaca attagtcaga gaattgtaag    600

tgctcagagc ttggctgaag atgatgtgga atgagaaaca aatgtcaaca taataaaatc    660

tcagttaaaa atattttaaa aattcttggt agttgagcag ctctggggga ataagggcaa    720

atatgcttgt tatgaactac actgaaatct accaaagtta atgtttactt tgtgtagatc    780

catttgtcta ttttatttat ttttcccagt gaaaagtgta ttttgataga gaacttttca    840

ttctataaat acactatgag ttactaaaat atcatggatt ttgtttattc ctgaaacata    900

gttacatagt taaactgtac atatgacatg gcttatgtta aaaataccca gtgctcagtt    960

ttgaaagata ggcaaaaaaa aaaaagtata ggagaaactg aagaatgtac acttttttag   1020

agggcacatt ttgctgtaaa tctggaaatt tgatagactt gactgtgttt gtgaaaactg   1080

agcattaaag gttttgattg atcctttctt tccatttaat ctctgagacg taaatatgtg   1140

aggtgtgctg ctgtgctggg ttaacagctt ccttcccttt ctgtgtagca gtcttgaaat   1200

gttctgttta aatcagtagg cttaatgtgt tctgggtatt tatctccttg tattttaaat   1260

atatgtagtt gcaaatagca ccaggaatta gatttctgta cacccctaat ctagccttgt   1320

gagcttcgct agttaatgtg tgctcacttt ccctccattt gttacgtgag agaatgcgtc   1380

tgctgatcac tgaagtgtcc cttttagctt ctgattcatt gggttctgtt gggcatcttt   1440

aaatccacct taacctgagg aatgtatgtg ggcaaccagg ccctgcattt ttttatattc   1500

tgaattttgc atgcttgcct gacttagtat ttctgaattg atgttttttt taatggtata   1560

actatcttga ttttcactga aattatatgg ttctgtcact actctgtaaa ttaatccgaa   1620

acttttaagg taactgggat gatctgcttg taaaaatgct tgttgccttt tgctttatct   1680

tcagtgtacc tccttaatcc tgcttcaact tgattatctt gtgaaacgat gagagtaagt   1740

tgcaaccttg tgactgaaaa cttgaaaaga gtggagcagg tgggacctct tattctcaaa   1800

tagtgacata ttctccgtag tcacagtttc agaactgagt aaggatcctt ggtacttggt   1860

ggcatctgtt gaactgagga gcatttctca ttgtaaagat tgcctttgtt ctgtctaaaa   1920

gtctggagaa atcccaaaga cttttcctat gtactaggca ttttattttg attgacttac   1980

aaactcttct taatcattat caatctcggt ttttttgtgg tgcagtggaa ggagaaatag   2040

gtctagtttc tgcctctgat tagccgcaca gccttgaaca aatcacattt catctttgaa   2100

cttacctcta ctgttagact aggcgactca catttgagga cttttctcgg gtatcttgag   2160

ggtttgtgat cctgaaccct taaacagtgc ttttttgtta cacaggaggg cttttttggg   2220

gggatgacca gtacagacat gccagttagt tttactagtg ggatcccaaa tccaaagcag   2280

tgtagtggtg attggtcagt gactaaccag gcagctaaga agtcttaggc agcagcccag   2340

acatgtatag aggggcagtt agagggagaa caggggtggg aaagggagca aggggcagat   2400

agctcagcaa ggaaagaatg ggctcagaaa aaggagggct ggctggagga gtgaggggca   2460

gcttaagttt ggggagggta gaaacgccgt ttccttggga actggagtgc agtatgagct   2520

gggtgtcact tggctctgaa catactggct ttgctgtaat gcttgaaaag gcgttggtat   2580

cttcatttta cagttcatta acccaagtac gttttcttat ttaaatgaca actttggtgc   2640

tttaaaatga ggtaccactt tttaaagcta gctgtgtcga gttaaagaaa aaatcagcag   2700

ttttttctcc cagaaatgta attgccaaac actattcatc cccatcttaa gttttacaag   2760

gtgatgtaat cagcttgttg tagtgatgct ggccaaatgg tgctcagcag gtgagaacaa   2820

aaaaacccca gatctcagtg aactaataca cagcttgagc gtttccatgt gctaatgttg   2880

cacacttact aaaaaacttt ggaaatggaa aataatgtat tagtgcaaca gttgatgtgc   2940

ttctttgggc aaagatatag ttttgttcca caatttgtac ttaaaagcga aagaacattg   3000

aaaacataga cttactggct gtagcaatgc tggcctgtta actgataact agaacttagg   3060

ttcacgttta tgtaaagtgt gtaaaaccta gtagagcttg catagtcggc actcagtaaa   3120

tgtttggttc cttttgcccc ttggtaagtt tattttacca tcctcccacc tgccattctg   3180

actttattaa atcaacatgt ggaccagagt gttaatgaga tgttattgca gaagagattg   3240

agaaaattgg tatatcatgc agataacata caaaatcttt ttgtaacgta aaaaatgcag   3300

ttttattatt gcttgtgcct caactgttta agtgaatatt aaagggcttg gagaaaactt   3360

tg                                                                  3362


<210>  7388
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  7388

Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala Leu 
1               5                   10                  15      


Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Lys Arg Arg Ser Asp Pro 
            20                  25                  30          


Asn Phe Lys Asn Arg Leu Arg Glu Arg Arg Lys Lys Gln Lys Leu Ala 
        35                  40                  45              


Lys Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu 
    50                  55                  60                  


Ala Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Leu Ala Gln Gly Glu Tyr Glu Lys Gly Val Asp His Leu Thr Asn Ala 
                85                  90                  95      


Ile Ala Val Cys Gly Gln Pro Gln Gln Leu Leu Gln Val Leu Gln Gln 
            100                 105                 110         


Thr Leu Pro Pro Pro Val Phe Gln Met Leu Leu Thr Lys Leu Pro Thr 
        115                 120                 125             


Ile Ser Gln Arg Ile Val Ser Ala Gln Ser Leu Ala Glu Asp Asp Val 
    130                 135                 140                 


Glu 
145 


<210>  7389
<211>  1244
<212>  DNA
<213>  Homosapiens

<400>  7389
atccttggta cttggtggca tctgttgaac tgaggagcat ttctcattgt aaagattgcc     60

tttgttctgt ctaaaagtct ggagaaatcc caaagacttt tcctatgtac taggcatttt    120

attttgattg acttacaaac tcttcttaat cattatcaat ctcggttttt ttgtggtgca    180

gtggaaggag aaataggtct agtttctgcc tctgattagc cgcacagcct tgaacaaatc    240

acatttcatc tttgaactta cctctactgt tagactaggc gactcacatt tgaggacttt    300

tctcgggtat cttgagggtt tgtgatcctg aacccttaaa cagtgctttt ttgttacaca    360

ggagggcttt tttgggggga tgaccagtac agacatgcca gttagtttta ctagtgggat    420

cccaaatcca aagcagtgta gtggtgattg gtcagtgact aaccaggcag ctaagaagtc    480

ttaggcagca gcccagacat gtatagaggg gcagttagag ggagaacagg ggtgggaaag    540

ggagcaaggg gcagatagct cagcaaggaa agaatgggct cagaaaaagg agggctggct    600

ggaggagtga ggggcagctt aagtttgggg agggtagaaa cgccgtttcc ttgggaactg    660

gagtgcagta tgagctgggt gtcacttggc tctgaacata ctggctttgc tgtaatgctt    720

gaaaaggcgt tggtatcttc attttacagt tcattaaccc aagtacgttt tcttatttaa    780

atgacaactt tggtgcttta aaatgaggta ccacttttta aagctagctg tgtcgagtta    840

aagaaaaaat cagcagtttt ttctcccaga aatgtaattg ccaaacacta ttcatcccca    900

tcttaagttt tacaaggtga tgtaatcagc ttgttgtagt gatgctggcc aaatggtgct    960

cagcaggtga gaacaaaaaa accccagatc tcagtgaact aatacacagc ttgagcgttt   1020

ccatgtgcta atgttgcaca cttactaaaa aactttggaa atggaaaata atgtattagt   1080

gcaacacatg tggaccagag tgttaatgag atgttattgc agaagagatt gagaaaattg   1140

gtatatcatg cagataacat acaaaatctt tttgtaacgt aaaaaatgca gttttattat   1200

tgcttgtgcc tcaactgttt aagtgaatat taaagggctt ggag                    1244


<210>  7390
<211>  68
<212>  PRT
<213>  Homosapiens

<400>  7390

Met Gly Ser Glu Lys Gly Gly Leu Ala Gly Gly Val Arg Gly Ser Leu 
1               5                   10                  15      


Ser Leu Gly Arg Val Glu Thr Pro Phe Pro Trp Glu Leu Glu Cys Ser 
            20                  25                  30          


Met Ser Trp Val Ser Leu Gly Ser Glu His Thr Gly Phe Ala Val Met 
        35                  40                  45              


Leu Glu Lys Ala Leu Val Ser Ser Phe Tyr Ser Ser Leu Thr Gln Val 
    50                  55                  60                  


Arg Phe Leu Ile 
65              


<210>  7391
<211>  1113
<212>  DNA
<213>  Homosapiens

<400>  7391
cctctgctca ggctctgccg cggacgacct cgaggccctt agttgactgg gaccggaagt     60

ggcgtgtgct cggcctttct gtgttcctgg cccgcggccg tcgggtgtga gctgcgccga    120

ccgctctgag ggttcgtggc ccaccgctcc ttcgcggtcc ctgccgccac cgtccacgct    180

cagcgttgta gagaagatgg tgggtcggaa cagcgccatc gccgccggtg tatgcggggc    240

ccttttcatt gggtactgca tctacttcga ccgcaaaaga cgaagtgacc ccaacttcaa    300

gaacaggctt cgagaacgaa gaaagaaaca gaagcttgcc aaggagagag ctgggctttc    360

caagttacct gaccttaaag atgctgaagc tgttcagaag ttcttccttg aagaaataca    420

gcttggtgaa gagttactag ctcaaggtga atatgagaag ggcgtagacc atctgacaaa    480

tgcaattgct gtgtgtggac agccacagca gttactgcag gtcttacagc aaactcttcc    540

accaccagtg ttccagatgc ttctgactaa gctcccaaca attagtcaga gaattgtaag    600

tgctcagagc ttggctgaag atgatgtgga atgagaaaca aatgtcaaca taataaaatc    660

tcagttaaaa atattttaaa aattcttggt agttgagcag ctctggggga ataagggcaa    720

atatgcttgt tatgaactac actgaaatct accaaagtta atgtttactt tgtgtagatc    780

catttgtcta ttttatttat ttttcccagt gaaaagtgta ttttgataga gaacttttca    840

ttctataaat acactatgag ttactaaaat atcatggatt ttgtttattc ctgaaacata    900

gttacatagt taaactgtac atatgacatg gcttatgtta aaaataccca gtgctcagtt    960

ttgaaagata ggcaaaaaaa aaaaagtata ggagaaactg aagaatgtac acttttttag   1020

agggcacatt ttgctgtaaa tctggaaatt tgatagactt gactgtgttt gtgaaaactg   1080

agcattaaag gttttgattg atcctttctt tcc                                1113


<210>  7392
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  7392

Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala Leu 
1               5                   10                  15      


Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Lys Arg Arg Ser Asp Pro 
            20                  25                  30          


Asn Phe Lys Asn Arg Leu Arg Glu Arg Arg Lys Lys Gln Lys Leu Ala 
        35                  40                  45              


Lys Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu 
    50                  55                  60                  


Ala Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Leu Ala Gln Gly Glu Tyr Glu Lys Gly Val Asp His Leu Thr Asn Ala 
                85                  90                  95      


Ile Ala Val Cys Gly Gln Pro Gln Gln Leu Leu Gln Val Leu Gln Gln 
            100                 105                 110         


Thr Leu Pro Pro Pro Val Phe Gln Met Leu Leu Thr Lys Leu Pro Thr 
        115                 120                 125             


Ile Ser Gln Arg Ile Val Ser Ala Gln Ser Leu Ala Glu Asp Asp Val 
    130                 135                 140                 


Glu 
145 


<210>  7393
<211>  865
<212>  DNA
<213>  Homosapiens

<400>  7393
cctctgctca ggctctgccg cggacgacct cgaggccctt agttgactgg gaccggaagt     60

ggcgtgtgct cggcctttct gtgttcctgg cccgcggccg tcgggtgtga gctgcgccga    120

ccgctctgag ggttcgtggc ccaccgctcc ttcgcggtcc ctgccgccac cgtccacgct    180

cagcgttgta gagaagatgg tgggtcggaa cagcgccatc gccgccggtg tatgcggggc    240

ccttttcatt gggtactgca tctacttcga ccgcaaaaga cgaagtgacc ccaacttcaa    300

gaacaggctt cgagaacgaa gaaagaaaca gaagcttgcc aaggagagag ctgggctttc    360

caagttacct gaccttaaag atgctgaagc tgttcagaag ttcttccttg aagaaataca    420

gcttggtgaa gagttactag ctcaaggtga atatgagaag ggcgtagacc atctgacaaa    480

tgcaattgct gtgtgtggac agccacagca gttactgcag gtcttacagc aaactcttcc    540

accaccagtg ttccagatgc ttctgactaa gctcccaaca attagtcaga gaattgtaag    600

tgctcagagc ttggctgaag atgatgtgga atgagaaaca aatgtcaaca taataaaatc    660

tcagttaaaa atattttaaa aattcttggt agttgagcag ctctggggga ataagggcaa    720

atatgcttgt tatgaactac actgaaatct accaaagtta atgtttactt tgtgtagatc    780

catttgtcta ttttatttat ttttcccagt gaaaagtgta ttttgataga gaacttttca    840

ttctataaat acactatgag ttact                                          865


<210>  7394
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  7394

Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala Leu 
1               5                   10                  15      


Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Lys Arg Arg Ser Asp Pro 
            20                  25                  30          


Asn Phe Lys Asn Arg Leu Arg Glu Arg Arg Lys Lys Gln Lys Leu Ala 
        35                  40                  45              


Lys Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu 
    50                  55                  60                  


Ala Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Leu Ala Gln Gly Glu Tyr Glu Lys Gly Val Asp His Leu Thr Asn Ala 
                85                  90                  95      


Ile Ala Val Cys Gly Gln Pro Gln Gln Leu Leu Gln Val Leu Gln Gln 
            100                 105                 110         


Thr Leu Pro Pro Pro Val Phe Gln Met Leu Leu Thr Lys Leu Pro Thr 
        115                 120                 125             


Ile Ser Gln Arg Ile Val Ser Ala Gln Ser Leu Ala Glu Asp Asp Val 
    130                 135                 140                 


Glu 
145 


<210>  7395
<211>  677
<212>  DNA
<213>  Homosapiens

<400>  7395
cctctgctca ggctctgccg cggacgacct cgaggccctt agttgactgg gaccggaagt     60

ggcgtgtgct cggcctttct gtgttcctgg cccgcggccg tcgggtgtga gctgcgccga    120

ccgctctgag ggttcgtggc ccaccgctcc ttcgcggtcc ctgccgccac cgtccacgct    180

cagcgttgta gagaagatgg tgggtcggaa cagcgccatc gccgccggtg tatgcggggc    240

ccttttcatt gggtactgca tctacttcga ccgcaaaaga cgaagtgacc ccaacttcaa    300

gaacaggctt cgagaacgaa gaaagaaaca gaagcttgcc aaggagagag ctgggctttc    360

caagttacct gaccttaaag atgctgaagc tgttcagaag ttcttccttg aagaaataca    420

gcttggtgaa gagttactag ctcaaggtga atatgagaag ggcgtagacc atctgacaaa    480

tgcaattgct gtgtgtggac agccacagca gttactgcag gtcttacagc aaactcttcc    540

accaccagtg ttccagatgc ttctgactaa gctcccaaca attagtcaga gaattgtaag    600

tgctcagagc ttggctgaag atgatgtgga atgagaaaca aatgtcaaca taataaaatc    660

tcagttaaaa atatttt                                                   677


<210>  7396
<211>  145
<212>  PRT
<213>  Homosapiens

<400>  7396

Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala Leu 
1               5                   10                  15      


Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Lys Arg Arg Ser Asp Pro 
            20                  25                  30          


Asn Phe Lys Asn Arg Leu Arg Glu Arg Arg Lys Lys Gln Lys Leu Ala 
        35                  40                  45              


Lys Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu 
    50                  55                  60                  


Ala Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Leu Ala Gln Gly Glu Tyr Glu Lys Gly Val Asp His Leu Thr Asn Ala 
                85                  90                  95      


Ile Ala Val Cys Gly Gln Pro Gln Gln Leu Leu Gln Val Leu Gln Gln 
            100                 105                 110         


Thr Leu Pro Pro Pro Val Phe Gln Met Leu Leu Thr Lys Leu Pro Thr 
        115                 120                 125             


Ile Ser Gln Arg Ile Val Ser Ala Gln Ser Leu Ala Glu Asp Asp Val 
    130                 135                 140                 


Glu 
145 


<210>  7397
<211>  940
<212>  DNA
<213>  Homosapiens

<400>  7397
gagacagagt ctcactctgt tgctcaggct ggagtgcttt ggcacgatct cagctcactg     60

cagcctctgc ctcccaggct ctagcgatcc tcccatctca gcttcctgag tagctaggac    120

tacagaatac agattctgtt catcttgctc tgaaattaaa taattctgaa ctcatgggga    180

gaaaactcag agtcatgcgt tctgttaata aagaaaaatt taaacaacaa aattcaaatc    240

cacgattgaa gaatgtcagt aaacctaagc agggacttaa ttttacttcc aaaactgcag    300

aaggacatcc taaaagctta tttattggag aaaaagctgt tctccttaaa acgaagaaga    360

aaggacagaa gaaaagtgga cgccctaaga aacagagaaa acagaaataa caaccaggaa    420

ctgctttttc ttttcctgct gagtactgct aataaaagtg ctattatctg ctgatagcat    480

cgtctgctat tcatgtgttg agttttatac ttctttatgg atggtgtatg tgaaatgtgg    540

agacttccac attctcagtt tattcacatt gtgatactac ctttgaaggt ttttttgttt    600

ttgttttgtt ttttgagatg gagtttggct gttgtctccc aggctggagt gcagtggcgt    660

gatcttggct cactgcaacc tctgccttct gggttcaagc gcttctcctg cctcagcctc    720

ccaagtagct gggattacag gcgcctgcca ccacgcctgg ctaatttttt gtatttttag    780

tagagacggg gtttcaccat gttggccagg ctggtctcga actcctgacc tcaggtgatc    840

cacctgcctt ggcctctcaa agtgctggga ttacaggcgt gagtcactgc acccaagcct    900

cctttctctt ttgcctatta aacctctgct cttaacctta                          940


<210>  7398
<211>  87
<212>  PRT
<213>  Homosapiens

<400>  7398

Met Asp Gly Val Cys Glu Met Trp Arg Leu Pro His Ser Gln Phe Ile 
1               5                   10                  15      


His Ile Val Ile Leu Pro Leu Lys Val Phe Leu Phe Leu Phe Cys Phe 
            20                  25                  30          


Leu Arg Trp Ser Leu Ala Val Val Ser Gln Ala Gly Val Gln Trp Arg 
        35                  40                  45              


Asp Leu Gly Ser Leu Gln Pro Leu Pro Ser Gly Phe Lys Arg Phe Ser 
    50                  55                  60                  


Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Arg Leu Pro Pro Arg 
65                  70                  75                  80  


Leu Ala Asn Phe Leu Tyr Phe 
                85          


<210>  7399
<211>  1015
<212>  DNA
<213>  Homosapiens

<400>  7399
ggtctagtga gtgattttta ttaactgtct ttttgtttca gagagacaag agatcggttt     60

ttgtggggaa tctcccttat aaagttgaag aatctgccat tgagaagcac tttctggact    120

gtggaagtat catggccgtg aggattgtga gagacaaaat gacaggcatc ggcaaagggt    180

ttggctatgt gctctttgag aatacagatt ctgttcatct tgctctgaaa ttaaataatt    240

ctgaactcat ggggagaaaa ctcagagtca tgcgttctgt taataaagaa aaatttaaac    300

aacaaaattc aaatccacga ttgaagaatg tcagtaaacc taagcaggga cttaatttta    360

cttccaaaac tgcagaagga catcctaaaa gcttatttat tggagaaaaa gctgttctcc    420

ttaaaacgaa gaagaaagga cagaagaaaa gtggacgccc taagaaacag agaaaacaga    480

aataacaacc aggaactgct ttttcttttc ctgctgagta ctgctaataa aagtgctatt    540

atctgctgat agcatcgtct gctattcatg tgttgagttt tatacttctt tatggatggt    600

gtatgtgaaa tgtggagact tccacattct cagtttattc acattgtgat actacctttg    660

aaggtttttt tgtttttgtt ttgttttttg agatggagtt tggctgttgt ctcccaggct    720

ggagtgcagt ggcgtgatct tggctcactg caacctctgc cttctgggtt caagcgcttc    780

tcctgcctca gcctcccaag tagctgggat tacaggcgcc tgccaccacg cctggctaat    840

tttttgtatt tttagtagag acggggtttc accatgttgg ccaggctggt ctcgaactcc    900

tgacctcagg tgatccacct gccttggcct ctcaaagtgc tgggattaca ggcgtgagtc    960

actgcaccca agcctccttt ctcttttgcc tattaaacct ctgctcttaa cctta        1015


<210>  7400
<211>  117
<212>  PRT
<213>  Homosapiens

<400>  7400

Met Ala Val Arg Ile Val Arg Asp Lys Met Thr Gly Ile Gly Lys Gly 
1               5                   10                  15      


Phe Gly Tyr Val Leu Phe Glu Asn Thr Asp Ser Val His Leu Ala Leu 
            20                  25                  30          


Lys Leu Asn Asn Ser Glu Leu Met Gly Arg Lys Leu Arg Val Met Arg 
        35                  40                  45              


Ser Val Asn Lys Glu Lys Phe Lys Gln Gln Asn Ser Asn Pro Arg Leu 
    50                  55                  60                  


Lys Asn Val Ser Lys Pro Lys Gln Gly Leu Asn Phe Thr Ser Lys Thr 
65                  70                  75                  80  


Ala Glu Gly His Pro Lys Ser Leu Phe Ile Gly Glu Lys Ala Val Leu 
                85                  90                  95      


Leu Lys Thr Lys Lys Lys Gly Gln Lys Lys Ser Gly Arg Pro Lys Lys 
            100                 105                 110         


Gln Arg Lys Gln Lys 
        115         


<210>  7401
<211>  433
<212>  DNA
<213>  Homosapiens

<400>  7401
ttgaagactc ttgatgagaa ttgcctggta gcttttttag aaagattgtc acagcgtttg     60

ttgccattgt tactgtattg tagttacctt tctgcttgtc tgctcccttt cttctattac    120

ttgataagct tctaaagtcc tttaacaaac atctcatgga tattcagggt tgttagcatt    180

aatggctcta tattggaaca gaagtataac agaattttgg atctaaatgg aaccctagag    240

ggtgtctagt ccaacatctc gtaatggagc gttccctgcc ctctggtcag ctaatacaat    300

ggggctttga cagaaagatg gctatacgaa ggaggtttat tcgtttaaaa tattgcatat    360

gggattacag gcgtgagtca ctgcacccaa gcctcctttc tcttttgcct attaaacctc    420

tgctcttaac ctt                                                       433


<210>  7402
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  7402

Met Glu Arg Ser Leu Pro Ser Gly Gln Leu Ile Gln Trp Gly Phe Asp 
1               5                   10                  15      


Arg Lys Met Ala Ile Arg Arg Arg Phe Ile Arg Leu Lys Tyr Cys Ile 
            20                  25                  30          


Trp Asp Tyr Arg Arg Glu Ser Leu His Pro Ser Leu Leu Ser Leu Leu 
        35                  40                  45              


Pro Ile Lys Pro Leu Leu Leu 
    50                  55  


<210>  7403
<211>  488
<212>  DNA
<213>  Homosapiens

<400>  7403
gagacagagt ctcactctgt tgctcaggct ggagtgcttt ggcacgatct cagctcactg     60

cagcctctgc ctcccaggct ctagcgatcc tcccatctca gcttcctgag tagctaggac    120

tacagaatac agattctgtt catcttgctc tgaaattaaa taattctgaa ctcatgggga    180

gaaaactcag agtcatgcgt tctgttaata aagaaaaatt taaacaacaa aattcaaatc    240

cacgattgaa gaatgtcagt aaacctaagc agggacttaa ttttacttcc aaaactgcag    300

aaggacatcc taaaagctta tttattggag aaaaagctgt tctccttaaa acgaagaaga    360

aaggacagaa gaaaagtgga cgccctaaga aacagagaaa acagaaataa caaccaggaa    420

ctgctttttc ttttcctgct gagtactgct aataaaagtg ctattatctg ctgatagcat    480

cgtctgct                                                             488


<210>  7404
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  7404

Met Gly Arg Lys Leu Arg Val Met Arg Ser Val Asn Lys Glu Lys Phe 
1               5                   10                  15      


Lys Gln Gln Asn Ser Asn Pro Arg Leu Lys Asn Val Ser Lys Pro Lys 
            20                  25                  30          


Gln Gly Leu Asn Phe Thr Ser Lys Thr Ala Glu Gly His Pro Lys Ser 
        35                  40                  45              


Leu Phe Ile Gly Glu Lys Ala Val Leu Leu Lys Thr Lys Lys Lys Gly 
    50                  55                  60                  


Gln Lys Lys Ser Gly Arg Pro Lys Lys Gln Arg Lys Gln Lys 
65                  70                  75              


<210>  7405
<211>  563
<212>  DNA
<213>  Homosapiens

<400>  7405
ggtctagtga gtgattttta ttaactgtct ttttgtttca gagagacaag agatcggttt     60

ttgtggggaa tctcccttat aaagttgaag aatctgccat tgagaagcac tttctggact    120

gtggaagtat catggccgtg aggattgtga gagacaaaat gacaggcatc ggcaaagggt    180

ttggctatgt gctctttgag aatacagatt ctgttcatct tgctctgaaa ttaaataatt    240

ctgaactcat ggggagaaaa ctcagagtca tgcgttctgt taataaagaa aaatttaaac    300

aacaaaattc aaatccacga ttgaagaatg tcagtaaacc taagcaggga cttaatttta    360

cttccaaaac tgcagaagga catcctaaaa gcttatttat tggagaaaaa gctgttctcc    420

ttaaaacgaa gaagaaagga cagaagaaaa gtggacgccc taagaaacag agaaaacaga    480

aataacaacc aggaactgct ttttcttttc ctgctgagta ctgctaataa aagtgctatt    540

atctgctgat agcatcgtct gct                                            563


<210>  7406
<211>  117
<212>  PRT
<213>  Homosapiens

<400>  7406

Met Ala Val Arg Ile Val Arg Asp Lys Met Thr Gly Ile Gly Lys Gly 
1               5                   10                  15      


Phe Gly Tyr Val Leu Phe Glu Asn Thr Asp Ser Val His Leu Ala Leu 
            20                  25                  30          


Lys Leu Asn Asn Ser Glu Leu Met Gly Arg Lys Leu Arg Val Met Arg 
        35                  40                  45              


Ser Val Asn Lys Glu Lys Phe Lys Gln Gln Asn Ser Asn Pro Arg Leu 
    50                  55                  60                  


Lys Asn Val Ser Lys Pro Lys Gln Gly Leu Asn Phe Thr Ser Lys Thr 
65                  70                  75                  80  


Ala Glu Gly His Pro Lys Ser Leu Phe Ile Gly Glu Lys Ala Val Leu 
                85                  90                  95      


Leu Lys Thr Lys Lys Lys Gly Gln Lys Lys Ser Gly Arg Pro Lys Lys 
            100                 105                 110         


Gln Arg Lys Gln Lys 
        115         


<210>  7407
<211>  5527
<212>  DNA
<213>  Homosapiens

<400>  7407
gcagccgctg gacccgccgc ccttcttccc catctctccc ccgggcctgc tggttttggg     60

ggggagaagg agagagggga ctctggacgt gccagggtca gatctcgcct ccgaggaagg    120

tgcagctgaa cctggtgttt tagaggatac cttggtccca gagtcatcat gaaggctgga    180

gtgcagtggt gcaatctcag cttactgcaa tctccgtctc ctgagttcaa gcagttctgc    240

ctcagcctcc tgagtagctg tgactacagg cccttgatga gcctccctat ttgacagtgg    300

gcactgatgt gagtgctaaa tacagaggag ccttttgtga agccaagatc aagacagcaa    360

aaagacttgt caaagtcaag gtgacattta gacatgattc ttcaacagtg gaagttcagg    420

atgaccacat aaagggccca ctaaaggtag gagctattgt ggaagtgaag aatcttgatg    480

gtgcatatca ggaagctgtt atcaataaac taacagatgc gagttggtac actgtagttt    540

ttgatgacgg agatgagaag acactgagac gatcttcact gtgcctgaaa ggagagaggc    600

attttgctga aagtgaaaca ttagaccagc tcccactcac caaccctgag cattttggca    660

ctccagtcat aggaaagaaa acaaatagag gaagaagatc taatcatata ccagaggaag    720

agtcttcatc atcctccagt gatgaagatg aggatgatag gaaacagatt gatgagctac    780

taggcaaagt tgtatgtgta gattacatta gtttggataa aaagaaagca ctgtggtttc    840

ctgcattggt ggtttgtcct gattgtagtg atgagattgc tgtaaaaaag gacaatattc    900

ttgttcgatc tttcaaagat ggaaaattta cttcagttcc aagaaaagat gtccatgaaa    960

ttactagtga cactgcacca aagcctgatg ctgttttaaa gcaagccttt gaacaggcac   1020

ttgaatttca caaaagtaga actattcctg ctaactggaa gactgaattg aaagaagata   1080

gctctagcag tgaagcagag gaagaagagg aggaggaaga tgatgaaaaa gaaaaggagg   1140

ataatagcag tgaagaagaa gaagaaatag aaccatttcc agaagaaagg gagaactttc   1200

ttcagcaatt gtacaaattt atggaagata gaggtacacc tattaacaaa cgacctgtac   1260

ttggatatcg aaatttgaat ctctttaagt tattcagact tgtacacaaa cttggaggat   1320

ttgataatat tgaaagtgga gctgtttgga aacaagtcta ccaagatctt ggaatccctg   1380

tcttaaattc agctgcagga tacaatgtta aatgtgctta taaaaaatac ttatatggtt   1440

ttgaggagta ctgtagatca gccaacattg aatttcagat ggcattgcca gagaaagttg   1500

ttaacaagca atgtaaggag tgtgaaaatg taaaagaaat aaaagttaag gaggaaaatg   1560

aaacagagat caaagaaata aagatggagg aggagaggaa tataatacca agagaagaaa   1620

agcctattga ggatgaaatt gaaagaaaag aaaatattaa gccctctctg ggaagtaaaa   1680

agaatttatt agaatctata cctacacatt ctgatcagga aaaagaagtt aacattaaaa   1740

aaccagaaga caatgaaaat ctggatgaca aagatgatga cacaactagg gtagatgaat   1800

ccctcaacat aaaggtagaa gctgaggaag aaaaagcaaa atctggatac gatgaatgga   1860

ttaaagcaga taaaatagta agacctgctg ataaaaatgt gccaaagata aaacatcgga   1920

agaaaataaa gaataaatta gacaaagaaa aagacaaaga tgaaaaatac tctccaaaaa   1980

actgtaaact tcggcgcttg tccaaaccac catttcagac aaatccatct cctgaaatgg   2040

tatccaaact ggatctcact gatgccaaaa actctgatac tgctcatatt aagtccatag   2100

aaattacttc gatccttaat ggacttcaag cttctgaaag ttctgctgaa gacagtgagc   2160

aggaagatga gagaggtgct caagacatgg ataataatgg caaagaggaa tctaagattg   2220

atcatttgac caacaacaga aatgatctta tttcaaagga ggaacagaac agttcatctt   2280

tgctagaaga aaacaaagtt catgcagatt tggtaatatc caaaccagtg tcaaaatctc   2340

cagaaagatt aaggaaagat atagaagtat tatccgaaga tactgattat gaagaagatg   2400

aagtcacaaa aaagagaaag gatgtcaaga aggacacaac agataaatct tcaaaaccac   2460

aaataaaacg tggtaaaaga aggtattgca atacagaaga gtgtctaaaa actggatcac   2520

ctggcaaaaa ggaagagaag gccaagaaca aagaatcact ttgcatggaa aacagtagca   2580

acagctcttc agatgaagat gaagaagaaa caaaagcaaa gatgacacca actaagaaat   2640

acaatggttt ggaggaaaaa agaaaatctc tacggacaac tggtttctat tcaggatttt   2700

cagaagtggc agaaaaaagg attaaacttt taaataactc tgatgaaaga cttcaaaaca   2760

gcagggccaa agatcgaaaa gatgtctggt caagtattca gggacagtgg cctaaaaaaa   2820

cgctgaaaga gcttttttca gactctgata ctgaggctgc agcttcccca ccgcatcctg   2880

ccccagagga gggggtggca gaggagtcac tgcagactgt ggctgaagag gagagttgtt   2940

cacccagtgt agaactagaa aaaccacctc cagtcaatgt cgatagtaaa cccattgaag   3000

aaaaaacagt agaggtcaat gacagaaaag cagaatttcc aagtagtggc agtaattcag   3060

tgctaaatac ccctcctact acacctgaat cgccttcatc agtcactgta acagaaggca   3120

gccggcagca gtcttctgta acagtatcag aaccactggc tccaaaccaa gaagaggttc   3180

gaagtatcaa gagtgaaact gatagcacaa ttgaggtgga tagtgttgct ggggagctcc   3240

aagacctcca gtctgaaggg aatagctcgc cagcaggttt tgatgccagt gtgagctcaa   3300

gcagtagtaa tcagccagaa ccagaacatc ctgaaaaagc ctgtacaggt cagaaaagag   3360

tgaaagatgc tcagggagga ggaagttcat caaaaaagca gaaaagaagc cataaagcaa   3420

cagtggtaaa caacaaaaag aagggaaaag gcacaaatag tagtgatagt gaagaacttt   3480

cagctggtga aagtataact aagagtcagc cagtcaaatc agtttccact ggaatgaagt   3540

ctcatagtac caaatctccc gcaaggacgc agtctccagg aaaatgtgga aagaatggtg   3600

ataaggatcc tgatctcaag gaacccagta atcgattacc caaagtttac aaatggagtt   3660

ttcagatgtc ggacctggaa aatatgacaa gtgccgaacg catcacaatt cttcaagaaa   3720

aacttcaaga aatcagaaaa cattatctgt cattaaaatc tgaagtagct tccattgatc   3780

ggaggagaaa gcgtttaaag aagaaagaga gagaaagtgc tgctacatcc tcatcctcct   3840

cttcaccttc atccagttcc ataacagctg ctgttatgtt aactttagct gaaccgtcaa   3900

tgtccagcgc atcacaaaat ggaatgcttc aaccactccc agaagacgtc cttcactccc   3960

aaaatgaggc ttttctgaaa cggcgaggac caccaaccga cggcgacaaa cctgctccct   4020

cacccagcgc ctcccttcgc cgccgcccgg cggccgactg ccggagggga gggggcgtgg   4080

ccagagagcg gaagtgcccg gaacccggaa gtgcgagctg gcgcgcagct gcagtctggg   4140

agtctttgga gtaagaatgg ccttggaagg gatgagcaaa cggaagagaa agagaagtgt   4200

ccaggaggga gagaatcctg acgacggcgt tcgcgggagt ccgccggaag actacaggct   4260

tggacaggtc gccagtagct tatttcgcgg cgaacaccat tccagaggtg gcaccggtcg   4320

gctggcgtcc ctcttcagtt ctctggagcc ccagattcaa cccgtgtacg tgcctgtgcc   4380

taaacaaacc atcaaaaaaa cgaaacggaa tgaggaggaa gaaagtacat cccagattga   4440

aagaccactt tcgcaagaac ctgccaaaaa agtgaaagcg aagaagaaac acactaacgc   4500

agaaaaaaag ttggcagaca gggaaagcgc tctagcgagt gctgatttag aagaagaaat   4560

tcaccagaaa caagggcaga aaaggaaaaa ttctcaacct ggtgttaaag tagcagatag   4620

aaaaatactt gatgacacag aagacacagt tgtcagtcaa agaaagaaaa ttcaaatcaa   4680

ccaagaagaa gagagattaa agaatgagag aactgtgttt gttgggaatt tgcctgttac   4740

atgtaataag aagaagctga agtcgttttt taaagagtat ggacaaatag aatctgtacg   4800

atttcgttct ctgattccag cagagggaac gctatccaaa aagttggcag caataaaacg   4860

taaaattcat cctgatcaga aaaatattaa tgcctatgtt gtgtttaagg aggagagtgc   4920

tgccacgcaa gcattgaaaa gaaatggggc ccagattgca gatggatttc gtattagagt   4980

tgatctcgca tctgagacct catctagaga caagagatcg gtttttgtgg ggaatctccc   5040

ttataaagtt gaagaatctg ccattgagaa gcactttctg gactgtggaa gtatcatggc   5100

cgtgaggatt gtgagagaca aaatgacagg catcggcaaa gggtttggct atgtgctctt   5160

tgagaataca gattctgttc atcttgctct gaaattaaat aattctgaac tcatggggag   5220

aaaactcaga gtcatgcgtt ctgttaataa agaaaaattt aaacaacaaa attcaaatcc   5280

acgattgaag aatgtcagta aacctaagca gggacttaat tttacttcca aaactgcaga   5340

aggacatcct aaaagcttat ttattggaga aaaagctgtt ctccttaaaa cgaagaagaa   5400

aggacagaag aaaagtggac gccctaagaa acagagaaaa cagaaataac aaccaggaac   5460

tgctttttct tttcctgctg agtactgcta ataaaagtgc tattatctgc tgatagcatc   5520

gtctgct                                                             5527


<210>  7408
<211>  977
<212>  PRT
<213>  Homosapiens

<400>  7408

Met Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr 
1               5                   10                  15      


Arg Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly 
            20                  25                  30          


Gly Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln 
        35                  40                  45              


Asp Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys 
    50                  55                  60                  


Cys Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser 
65                  70                  75                  80  


Ala Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys 
                85                  90                  95      


Gln Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu 
            100                 105                 110         


Asn Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile 
        115                 120                 125             


Ile Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu 
    130                 135                 140                 


Asn Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile 
145                 150                 155                 160 


Pro Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu 
                165                 170                 175     


Asp Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp 
            180                 185                 190         


Glu Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser 
        195                 200                 205             


Gly Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile Val Arg Pro Ala Asp 
    210                 215                 220                 


Lys Asn Val Pro Lys Ile Lys His Arg Lys Lys Ile Lys Asn Lys Leu 
225                 230                 235                 240 


Asp Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser Pro Lys Asn Cys Lys 
                245                 250                 255     


Leu Arg Arg Leu Ser Lys Pro Pro Phe Gln Thr Asn Pro Ser Pro Glu 
            260                 265                 270         


Met Val Ser Lys Leu Asp Leu Thr Asp Ala Lys Asn Ser Asp Thr Ala 
        275                 280                 285             


His Ile Lys Ser Ile Glu Ile Thr Ser Ile Leu Asn Gly Leu Gln Ala 
    290                 295                 300                 


Ser Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu Asp Glu Arg Gly Ala 
305                 310                 315                 320 


Gln Asp Met Asp Asn Asn Gly Lys Glu Glu Ser Lys Ile Asp His Leu 
                325                 330                 335     


Thr Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu Glu Gln Asn Ser Ser 
            340                 345                 350         


Ser Leu Leu Glu Glu Asn Lys Val His Ala Asp Leu Val Ile Ser Lys 
        355                 360                 365             


Pro Val Ser Lys Ser Pro Glu Arg Leu Arg Lys Asp Ile Glu Val Leu 
    370                 375                 380                 


Ser Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val Thr Lys Lys Arg Lys 
385                 390                 395                 400 


Asp Val Lys Lys Asp Thr Thr Asp Lys Ser Ser Lys Pro Gln Ile Lys 
                405                 410                 415     


Arg Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu Cys Leu Lys Thr Gly 
            420                 425                 430         


Ser Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn Lys Glu Ser Leu Cys 
        435                 440                 445             


Met Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu Asp Glu Glu Glu Thr 
    450                 455                 460                 


Lys Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn Gly Leu Glu Glu Lys 
465                 470                 475                 480 


Arg Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser Gly Phe Ser Glu Val 
                485                 490                 495     


Ala Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser Asp Glu Arg Leu Gln 
            500                 505                 510         


Asn Ser Arg Ala Lys Asp Arg Lys Asp Val Trp Ser Ser Ile Gln Gly 
        515                 520                 525             


Gln Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe Ser Asp Ser Asp Thr 
    530                 535                 540                 


Glu Ala Ala Ala Ser Pro Pro His Pro Ala Pro Glu Glu Gly Val Ala 
545                 550                 555                 560 


Glu Glu Ser Leu Gln Thr Val Ala Glu Glu Glu Ser Cys Ser Pro Ser 
                565                 570                 575     


Val Glu Leu Glu Lys Pro Pro Pro Val Asn Val Asp Ser Lys Pro Ile 
            580                 585                 590         


Glu Glu Lys Thr Val Glu Val Asn Asp Arg Lys Ala Glu Phe Pro Ser 
        595                 600                 605             


Ser Gly Ser Asn Ser Val Leu Asn Thr Pro Pro Thr Thr Pro Glu Ser 
    610                 615                 620                 


Pro Ser Ser Val Thr Val Thr Glu Gly Ser Arg Gln Gln Ser Ser Val 
625                 630                 635                 640 


Thr Val Ser Glu Pro Leu Ala Pro Asn Gln Glu Glu Val Arg Ser Ile 
                645                 650                 655     


Lys Ser Glu Thr Asp Ser Thr Ile Glu Val Asp Ser Val Ala Gly Glu 
            660                 665                 670         


Leu Gln Asp Leu Gln Ser Glu Gly Asn Ser Ser Pro Ala Gly Phe Asp 
        675                 680                 685             


Ala Ser Val Ser Ser Ser Ser Ser Asn Gln Pro Glu Pro Glu His Pro 
    690                 695                 700                 


Glu Lys Ala Cys Thr Gly Gln Lys Arg Val Lys Asp Ala Gln Gly Gly 
705                 710                 715                 720 


Gly Ser Ser Ser Lys Lys Gln Lys Arg Ser His Lys Ala Thr Val Val 
                725                 730                 735     


Asn Asn Lys Lys Lys Gly Lys Gly Thr Asn Ser Ser Asp Ser Glu Glu 
            740                 745                 750         


Leu Ser Ala Gly Glu Ser Ile Thr Lys Ser Gln Pro Val Lys Ser Val 
        755                 760                 765             


Ser Thr Gly Met Lys Ser His Ser Thr Lys Ser Pro Ala Arg Thr Gln 
    770                 775                 780                 


Ser Pro Gly Lys Cys Gly Lys Asn Gly Asp Lys Asp Pro Asp Leu Lys 
785                 790                 795                 800 


Glu Pro Ser Asn Arg Leu Pro Lys Val Tyr Lys Trp Ser Phe Gln Met 
                805                 810                 815     


Ser Asp Leu Glu Asn Met Thr Ser Ala Glu Arg Ile Thr Ile Leu Gln 
            820                 825                 830         


Glu Lys Leu Gln Glu Ile Arg Lys His Tyr Leu Ser Leu Lys Ser Glu 
        835                 840                 845             


Val Ala Ser Ile Asp Arg Arg Arg Lys Arg Leu Lys Lys Lys Glu Arg 
    850                 855                 860                 


Glu Ser Ala Ala Thr Ser Ser Ser Ser Ser Ser Pro Ser Ser Ser Ser 
865                 870                 875                 880 


Ile Thr Ala Ala Val Met Leu Thr Leu Ala Glu Pro Ser Met Ser Ser 
                885                 890                 895     


Ala Ser Gln Asn Gly Met Leu Gln Pro Leu Pro Glu Asp Val Leu His 
            900                 905                 910         


Ser Gln Asn Glu Ala Phe Leu Lys Arg Arg Gly Pro Pro Thr Asp Gly 
        915                 920                 925             


Asp Lys Pro Ala Pro Ser Pro Ser Ala Ser Leu Arg Arg Arg Pro Ala 
    930                 935                 940                 


Ala Asp Cys Arg Arg Gly Gly Gly Val Ala Arg Glu Arg Lys Cys Pro 
945                 950                 955                 960 


Glu Pro Gly Ser Ala Ser Trp Arg Ala Ala Ala Val Trp Glu Ser Leu 
                965                 970                 975     


Glu 
    


<210>  7409
<211>  5785
<212>  DNA
<213>  Homosapiens

<400>  7409
gcagccgctg gacccgccgc ccttcttccc catctctccc ccgggcctgc tggttttggg     60

ggggagaagg agagagggga ctctggacgt gccagggtca gatctcgcct ccgaggaagg    120

tgcagctgaa cctggtgttt tagaggatac cttggtccca gagtcatcat gaaggctgga    180

gtgcagtggt gcaatctcag cttactgcaa tctccgtctc ctgagttcaa gcagttctgc    240

ctcagcctcc tgagtagctg tgactacagg cccttgatga gcctccctat ttgacagtgg    300

gcactgatgt gagtgctaaa tacagaggag ccttttgtga agccaagatc aagacagcaa    360

aaagacttgt caaagtcaag gtgacattta gacatgattc ttcaacagtg gaagttcagg    420

atgaccacat aaagggccca ctaaaggtag gagctattgt ggaagtgaag aatcttgatg    480

gtgcatatca ggaagctgtt atcaataaac taacagatgc gagttggtac actgtagttt    540

ttgatgacgg agatgagaag acactgagac gatcttcact gtgcctgaaa ggagagaggc    600

attttgctga aagtgaaaca ttagaccagc tcccactcac caaccctgag cattttggca    660

ctccagtcat aggaaagaaa acaaatagag gaagaagatc taatcatata ccagaggaag    720

agtcttcatc atcctccagt gatgaagatg aggatgatag gaaacagatt gatgagctac    780

taggcaaagt tgtatgtgta gattacatta gtttggataa aaagaaagca ctgtggtttc    840

ctgcattggt ggtttgtcct gattgtagtg atgagattgc tgtaaaaaag gacaatattc    900

ttgttcgatc tttcaaagat ggaaaattta cttcagttcc aagaaaagat gtccatgaaa    960

ttactagtga cactgcacca aagcctgatg ctgttttaaa gcaagccttt gaacaggcac   1020

ttgaatttca caaaagtaga actattcctg ctaactggaa gactgaattg aaagaagata   1080

gctctagcag tgaagcagag gaagaagagg aggaggaaga tgatgaaaaa gaaaaggagg   1140

ataatagcag tgaagaagaa gaagaaatag aaccatttcc agaagaaagg gagaactttc   1200

ttcagcaatt gtacaaattt atggaagata gaggtacacc tattaacaaa cgacctgtac   1260

ttggatatcg aaatttgaat ctctttaagt tattcagact tgtacacaaa cttggaggat   1320

ttgataatat tgaaagtgga gctgtttgga aacaagtcta ccaagatctt ggaatccctg   1380

tcttaaattc agctgcagga tacaatgtta aatgtgctta taaaaaatac ttatatggtt   1440

ttgaggagta ctgtagatca gccaacattg aatttcagat ggcattgcca gagaaagttg   1500

ttaacaagca atgtaaggag tgtgaaaatg taaaagaaat aaaagttaag gaggaaaatg   1560

aaacagagat caaagaaata aagatggagg aggagaggaa tataatacca agagaagaaa   1620

agcctattga ggatgaaatt gaaagaaaag aaaatattaa gccctctctg ggaagtaaaa   1680

agaatttatt agaatctata cctacacatt ctgatcagga aaaagaagtt aacattaaaa   1740

aaccagaaga caatgaaaat ctggatgaca aagatgatga cacaactagg gtagatgaat   1800

ccctcaacat aaaggtagaa gctgaggaag aaaaagcaaa atctggagat gaaacgaata   1860

aagaagaaga tgaagatgat gaagaagcag aagaggagga ggaggaggaa gaagaagaag   1920

aggatgaaga tgatgatgac aacaatgagg aagaggagtt tgagtgctat ccaccaggca   1980

tgaaagtcca agtgcggtat ggacgaggga aaaatcaaaa aatgtatgaa gctagtatta   2040

aagattctga tgtcgaaggt ggagaggtcc tttacttggt gcattactgc ggatggaatg   2100

tgagatacga tgaatggatt aaagcagata aaatagtaag acctgctgat aaaaatgtgc   2160

caaagataaa acatcggaag aaaataaaga ataaattaga caaagaaaaa gacaaagatg   2220

aaaaatactc tccaaaaaac tgtaaacttc ggcgcttgtc caaaccacca tttcagacaa   2280

atccatctcc tgaaatggta tccaaactgg atctcactga tgccaaaaac tctgatactg   2340

ctcatattaa gtccatagaa attacttcga tccttaatgg acttcaagct tctgaaagtt   2400

ctgctgaaga cagtgagcag gaagatgaga gaggtgctca agacatggat aataatggca   2460

aagaggaatc taagattgat catttgacca acaacagaaa tgatcttatt tcaaaggagg   2520

aacagaacag ttcatctttg ctagaagaaa acaaagttca tgcagatttg gtaatatcca   2580

aaccagtgtc aaaatctcca gaaagattaa ggaaagatat agaagtatta tccgaagata   2640

ctgattatga agaagatgaa gtcacaaaaa agagaaagga tgtcaagaag gacacaacag   2700

ataaatcttc aaaaccacaa ataaaacgtg gtaaaagaag gtattgcaat acagaagagt   2760

gtctaaaaac tggatcacct ggcaaaaagg aagagaaggc caagaacaaa gaatcacttt   2820

gcatggaaaa cagtagcaac agctcttcag atgaagatga agaagaaaca aaagcaaaga   2880

tgacaccaac taagaaatac aatggtttgg aggaaaaaag aaaatctcta cggacaactg   2940

gtttctattc aggattttca gaagtggcag aaaaaaggat taaactttta aataactctg   3000

atgaaagact tcaaaacagc agggccaaag atcgaaaaga tgtctggtca agtattcagg   3060

gacagtggcc taaaaaaacg ctgaaagagc ttttttcaga ctctgatact gaggctgcag   3120

cttccccacc gcatcctgcc ccagaggagg gggtggcaga ggagtcactg cagactgtgg   3180

ctgaagagga gagttgttca cccagtgtag aactagaaaa accacctcca gtcaatgtcg   3240

atagtaaacc cattgaagaa aaaacagtag aggtcaatga cagaaaagca gaatttccaa   3300

gtagtggcag taattcagtg ctaaataccc ctcctactac acctgaatcg ccttcatcag   3360

tcactgtaac agaaggcagc cggcagcagt cttctgtaac agtatcagaa ccactggctc   3420

caaaccaaga agaggttcga agtatcaaga gtgaaactga tagcacaatt gaggtggata   3480

gtgttgctgg ggagctccaa gacctccagt ctgaagggaa tagctcgcca gcaggttttg   3540

atgccagtgt gagctcaagc agtagtaatc agccagaacc agaacatcct gaaaaagcct   3600

gtacaggtca gaaaagagtg aaagatgctc agggaggagg aagttcatca aaaaagcaga   3660

aaagaagcca taaagcaaca gtggtaaaca acaaaaagaa gggaaaaggc acaaatagta   3720

gtgatagtga agaactttca gctggtgaaa gtataactaa gagtcagcca gtcaaatcag   3780

tttccactgg aatgaagtct catagtacca aatctcccgc aaggacgcag tctccaggaa   3840

aatgtggaaa gaatggtgat aaggatcctg atctcaagga acccagtaat cgattaccca   3900

aagtttacaa atggagtttt cagatgtcgg acctggaaaa tatgacaagt gccgaacgca   3960

tcacaattct tcaagaaaaa cttcaagaaa tcagaaaaca ttatctgtca ttaaaatctg   4020

aagtagcttc cattgatcgg aggagaaagc gtttaaagaa gaaagagaga gaaagtgctg   4080

ctacatcctc atcctcctct tcaccttcat ccagttccat aacagctgct gttatgttaa   4140

ctttagctga accgtcaatg tccagcgcat cacaaaatgg aatgcttcaa ccactcccag   4200

aagacgtcct tcactcccaa aatgaggctt ttctgaaacg gcgaggacca ccaaccgacg   4260

gcgacaaacc tgctccctca cccagcgcct cccttcgccg ccgcccggcg gccgactgcc   4320

ggaggggagg gggcgtggcc agagagcgga agtgcccgga acccggaagt gcgagctggc   4380

gcgcagctgc agtctgggag tctttggagt aagaatggcc ttggaaggga tgagcaaacg   4440

gaagagaaag agaagtgtcc aggagggaga gaatcctgac gacggcgttc gcgggagtcc   4500

gccggaagac tacaggcttg gacaggtcgc cagtagctta tttcgcggcg aacaccattc   4560

cagaggtggc accggtcggc tggcgtccct cttcagttct ctggagcccc agattcaacc   4620

cgtgtacgtg cctgtgccta aacaaaccat caaaaaaacg aaacggaatg aggaggaaga   4680

aagtacatcc cagattgaaa gaccactttc gcaagaacct gccaaaaaag tgaaagcgaa   4740

gaagaaacac actaacgcag aaaaaaagtt ggcagacagg gaaagcgctc tagcgagtgc   4800

tgatttagaa gaagaaattc accagaaaca agggcagaaa aggaaaaatt ctcaacctgg   4860

tgttaaagta gcagatagaa aaatacttga tgacacagaa gacacagttg tcagtcaaag   4920

aaagaaaatt caaatcaacc aagaagaaga gagattaaag aatgagagaa ctgtgtttgt   4980

tgggaatttg cctgttacat gtaataagaa gaagctgaag tcgtttttta aagagtatgg   5040

acaaatagaa tctgtacgat ttcgttctct gattccagca gagggaacgc tatccaaaaa   5100

gttggcagca ataaaacgta aaattcatcc tgatcagaaa aatattaatg cctatgttgt   5160

gtttaaggag gagagtgctg ccacgcaagc attgaaaaga aatggggccc agattgcaga   5220

tggatttcgt attagagttg atctcgcatc tgagacctca tctagagaca agagatcggt   5280

ttttgtgggg aatctccctt ataaagttga agaatctgcc attgagaagc actttctgga   5340

ctgtggaagt atcatggccg tgaggattgt gagagacaaa atgacaggca tcggcaaagg   5400

gtttggctat gtgctctttg agaatacaga ttctgttcat cttgctctga aattaaataa   5460

ttctgaactc atggggagaa aactcagagt catgcgttct gttaataaag aaaaatttaa   5520

acaacaaaat tcaaatccac gattgaagaa tgtcagtaaa cctaagcagg gacttaattt   5580

tacttccaaa actgcagaag gacatcctaa aagcttattt attggagaaa aagctgttct   5640

ccttaaaacg aagaagaaag gacagaagaa aagtggacgc cctaagaaac agagaaaaca   5700

gaaataacaa ccaggaactg ctttttcttt tcctgctgag tactgctaat aaaagtgcta   5760

ttatctgctg atagcatcgt ctgct                                         5785


<210>  7410
<211>  1063
<212>  PRT
<213>  Homosapiens

<400>  7410

Met Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr 
1               5                   10                  15      


Arg Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly 
            20                  25                  30          


Gly Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln 
        35                  40                  45              


Asp Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys 
    50                  55                  60                  


Cys Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser 
65                  70                  75                  80  


Ala Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys 
                85                  90                  95      


Gln Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu 
            100                 105                 110         


Asn Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile 
        115                 120                 125             


Ile Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu 
    130                 135                 140                 


Asn Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile 
145                 150                 155                 160 


Pro Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu 
                165                 170                 175     


Asp Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp 
            180                 185                 190         


Glu Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser 
        195                 200                 205             


Gly Asp Glu Thr Asn Lys Glu Glu Asp Glu Asp Asp Glu Glu Ala Glu 
    210                 215                 220                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Asp 
225                 230                 235                 240 


Asn Asn Glu Glu Glu Glu Phe Glu Cys Tyr Pro Pro Gly Met Lys Val 
                245                 250                 255     


Gln Val Arg Tyr Gly Arg Gly Lys Asn Gln Lys Met Tyr Glu Ala Ser 
            260                 265                 270         


Ile Lys Asp Ser Asp Val Glu Gly Gly Glu Val Leu Tyr Leu Val His 
        275                 280                 285             


Tyr Cys Gly Trp Asn Val Arg Tyr Asp Glu Trp Ile Lys Ala Asp Lys 
    290                 295                 300                 


Ile Val Arg Pro Ala Asp Lys Asn Val Pro Lys Ile Lys His Arg Lys 
305                 310                 315                 320 


Lys Ile Lys Asn Lys Leu Asp Lys Glu Lys Asp Lys Asp Glu Lys Tyr 
                325                 330                 335     


Ser Pro Lys Asn Cys Lys Leu Arg Arg Leu Ser Lys Pro Pro Phe Gln 
            340                 345                 350         


Thr Asn Pro Ser Pro Glu Met Val Ser Lys Leu Asp Leu Thr Asp Ala 
        355                 360                 365             


Lys Asn Ser Asp Thr Ala His Ile Lys Ser Ile Glu Ile Thr Ser Ile 
    370                 375                 380                 


Leu Asn Gly Leu Gln Ala Ser Glu Ser Ser Ala Glu Asp Ser Glu Gln 
385                 390                 395                 400 


Glu Asp Glu Arg Gly Ala Gln Asp Met Asp Asn Asn Gly Lys Glu Glu 
                405                 410                 415     


Ser Lys Ile Asp His Leu Thr Asn Asn Arg Asn Asp Leu Ile Ser Lys 
            420                 425                 430         


Glu Glu Gln Asn Ser Ser Ser Leu Leu Glu Glu Asn Lys Val His Ala 
        435                 440                 445             


Asp Leu Val Ile Ser Lys Pro Val Ser Lys Ser Pro Glu Arg Leu Arg 
    450                 455                 460                 


Lys Asp Ile Glu Val Leu Ser Glu Asp Thr Asp Tyr Glu Glu Asp Glu 
465                 470                 475                 480 


Val Thr Lys Lys Arg Lys Asp Val Lys Lys Asp Thr Thr Asp Lys Ser 
                485                 490                 495     


Ser Lys Pro Gln Ile Lys Arg Gly Lys Arg Arg Tyr Cys Asn Thr Glu 
            500                 505                 510         


Glu Cys Leu Lys Thr Gly Ser Pro Gly Lys Lys Glu Glu Lys Ala Lys 
        515                 520                 525             


Asn Lys Glu Ser Leu Cys Met Glu Asn Ser Ser Asn Ser Ser Ser Asp 
    530                 535                 540                 


Glu Asp Glu Glu Glu Thr Lys Ala Lys Met Thr Pro Thr Lys Lys Tyr 
545                 550                 555                 560 


Asn Gly Leu Glu Glu Lys Arg Lys Ser Leu Arg Thr Thr Gly Phe Tyr 
                565                 570                 575     


Ser Gly Phe Ser Glu Val Ala Glu Lys Arg Ile Lys Leu Leu Asn Asn 
            580                 585                 590         


Ser Asp Glu Arg Leu Gln Asn Ser Arg Ala Lys Asp Arg Lys Asp Val 
        595                 600                 605             


Trp Ser Ser Ile Gln Gly Gln Trp Pro Lys Lys Thr Leu Lys Glu Leu 
    610                 615                 620                 


Phe Ser Asp Ser Asp Thr Glu Ala Ala Ala Ser Pro Pro His Pro Ala 
625                 630                 635                 640 


Pro Glu Glu Gly Val Ala Glu Glu Ser Leu Gln Thr Val Ala Glu Glu 
                645                 650                 655     


Glu Ser Cys Ser Pro Ser Val Glu Leu Glu Lys Pro Pro Pro Val Asn 
            660                 665                 670         


Val Asp Ser Lys Pro Ile Glu Glu Lys Thr Val Glu Val Asn Asp Arg 
        675                 680                 685             


Lys Ala Glu Phe Pro Ser Ser Gly Ser Asn Ser Val Leu Asn Thr Pro 
    690                 695                 700                 


Pro Thr Thr Pro Glu Ser Pro Ser Ser Val Thr Val Thr Glu Gly Ser 
705                 710                 715                 720 


Arg Gln Gln Ser Ser Val Thr Val Ser Glu Pro Leu Ala Pro Asn Gln 
                725                 730                 735     


Glu Glu Val Arg Ser Ile Lys Ser Glu Thr Asp Ser Thr Ile Glu Val 
            740                 745                 750         


Asp Ser Val Ala Gly Glu Leu Gln Asp Leu Gln Ser Glu Gly Asn Ser 
        755                 760                 765             


Ser Pro Ala Gly Phe Asp Ala Ser Val Ser Ser Ser Ser Ser Asn Gln 
    770                 775                 780                 


Pro Glu Pro Glu His Pro Glu Lys Ala Cys Thr Gly Gln Lys Arg Val 
785                 790                 795                 800 


Lys Asp Ala Gln Gly Gly Gly Ser Ser Ser Lys Lys Gln Lys Arg Ser 
                805                 810                 815     


His Lys Ala Thr Val Val Asn Asn Lys Lys Lys Gly Lys Gly Thr Asn 
            820                 825                 830         


Ser Ser Asp Ser Glu Glu Leu Ser Ala Gly Glu Ser Ile Thr Lys Ser 
        835                 840                 845             


Gln Pro Val Lys Ser Val Ser Thr Gly Met Lys Ser His Ser Thr Lys 
    850                 855                 860                 


Ser Pro Ala Arg Thr Gln Ser Pro Gly Lys Cys Gly Lys Asn Gly Asp 
865                 870                 875                 880 


Lys Asp Pro Asp Leu Lys Glu Pro Ser Asn Arg Leu Pro Lys Val Tyr 
                885                 890                 895     


Lys Trp Ser Phe Gln Met Ser Asp Leu Glu Asn Met Thr Ser Ala Glu 
            900                 905                 910         


Arg Ile Thr Ile Leu Gln Glu Lys Leu Gln Glu Ile Arg Lys His Tyr 
        915                 920                 925             


Leu Ser Leu Lys Ser Glu Val Ala Ser Ile Asp Arg Arg Arg Lys Arg 
    930                 935                 940                 


Leu Lys Lys Lys Glu Arg Glu Ser Ala Ala Thr Ser Ser Ser Ser Ser 
945                 950                 955                 960 


Ser Pro Ser Ser Ser Ser Ile Thr Ala Ala Val Met Leu Thr Leu Ala 
                965                 970                 975     


Glu Pro Ser Met Ser Ser Ala Ser Gln Asn Gly Met Leu Gln Pro Leu 
            980                 985                 990         


Pro Glu Asp Val Leu His Ser Gln  Asn Glu Ala Phe Leu  Lys Arg Arg 
        995                 1000                 1005             


Gly Pro  Pro Thr Asp Gly Asp  Lys Pro Ala Pro Ser  Pro Ser Ala 
    1010                 1015                 1020             


Ser Leu  Arg Arg Arg Pro Ala  Ala Asp Cys Arg Arg  Gly Gly Gly 
    1025                 1030                 1035             


Val Ala  Arg Glu Arg Lys Cys  Pro Glu Pro Gly Ser  Ala Ser Trp 
    1040                 1045                 1050             


Arg Ala  Ala Ala Val Trp Glu  Ser Leu Glu 
    1055                 1060             


<210>  7411
<211>  4636
<212>  DNA
<213>  Homosapiens

<400>  7411
gcggagggag actcttgagc ttcatcttgc cgccgccacg gccaccgcct ggacctttgc     60

ccggagggag ctgcagaggg tccatcgccg ccgtcctctg gagggcagcg cgattggggg    120

cccggacctc cagtccgggg gggatttttc gtcgtccccc tccccccaac cagggagccc    180

gagcggccgc caaacaaagg taccagtcgc cgccgcggga ggaggaagat gatgaaaaag    240

aaaaggagga taatagcagt gaagaagaag aagaaataga accatttcca gaagaaaggg    300

agaactttct tcagcaattg tacaaattta tggaagatag aggtacacct attaacaaac    360

gacctgtact tggatatcga aatttgaatc tctttaagtt attcagactt gtacacaaac    420

ttggaggatt tgataatatt gaaagtggag ctgtttggaa acaagtctac caagatcttg    480

gaatccctgt cttaaattca gctgcaggat acaatgttaa atgtgcttat aaaaaatact    540

tatatggttt tgaggagtac tgtagatcag ccaacattga atttcagatg gcattgccag    600

agaaagttgt taacaagcaa tgtaaggagt gtgaaaatgt aaaagaaata aaagttaagg    660

aggaaaatga aacagagatc aaagaaataa agatggagga ggagaggaat ataataccaa    720

gagaagaaaa gcctattgag gatgaaattg aaagaaaaga aaatattaag ccctctctgg    780

gaagtaaaaa gaatttatta gaatctatac ctacacattc tgatcaggaa aaagaagtta    840

acattaaaaa accagaagac aatgaaaatc tggatgacaa agatgatgac acaactaggg    900

tagatgaatc cctcaacata aaggtagaag ctgaggaaga aaaagcaaaa tctggatacg    960

atgaatggat taaagcagat aaaatagtaa gacctgctga taaaaatgtg ccaaagataa   1020

aacatcggaa gaaaataaag aataaattag acaaagaaaa agacaaagat gaaaaatact   1080

ctccaaaaaa ctgtaaactt cggcgcttgt ccaaaccacc atttcagaca aatccatctc   1140

ctgaaatggt atccaaactg gatctcactg atgccaaaaa ctctgatact gctcatatta   1200

agtccataga aattacttcg atccttaatg gacttcaagc ttctgaaagt tctgctgaag   1260

acagtgagca ggaagatgag agaggtgctc aagacatgga taataatggc aaagaggaat   1320

ctaagattga tcatttgacc aacaacagaa atgatcttat ttcaaaggag gaacagaaca   1380

gttcatcttt gctagaagaa aacaaagttc atgcagattt ggtaatatcc aaaccagtgt   1440

caaaatctcc agaaagatta aggaaagata tagaagtatt atccgaagat actgattatg   1500

aagaagatga agtcacaaaa aagagaaagg atgtcaagaa ggacacaaca gataaatctt   1560

caaaaccaca aataaaacgt ggtaaaagaa ggtattgcaa tacagaagag tgtctaaaaa   1620

ctggatcacc tggcaaaaag gaagagaagg ccaagaacaa agaatcactt tgcatggaaa   1680

acagtagcaa cagctcttca gatgaagatg aagaagaaac aaaagcaaag atgacaccaa   1740

ctaagaaata caatggtttg gaggaaaaaa gaaaatctct acggacaact ggtttctatt   1800

caggattttc agaagtggca gaaaaaagga ttaaactttt aaataactct gatgaaagac   1860

ttcaaaacag cagggccaaa gatcgaaaag atgtctggtc aagtattcag ggacagtggc   1920

ctaaaaaaac gctgaaagag cttttttcag actctgatac tgaggctgca gcttccccac   1980

cgcatcctgc cccagaggag ggggtggcag aggagtcact gcagactgtg gctgaagagg   2040

agagttgttc acccagtgta gaactagaaa aaccacctcc agtcaatgtc gatagtaaac   2100

ccattgaaga aaaaacagta gaggtcaatg acagaaaagc agaatttcca agtagtggca   2160

gtaattcagt gctaaatacc cctcctacta cacctgaatc gccttcatca gtcactgtaa   2220

cagaaggcag ccggcagcag tcttctgtaa cagtatcaga accactggct ccaaaccaag   2280

aagaggttcg aagtatcaag agtgaaactg atagcacaat tgaggtggat agtgttgctg   2340

gggagctcca agacctccag tctgaaggga atagctcgcc agcaggtttt gatgccagtg   2400

tgagctcaag cagtagtaat cagccagaac cagaacatcc tgaaaaagcc tgtacaggtc   2460

agaaaagagt gaaagatgct cagggaggag gaagttcatc aaaaaagcag aaaagaagcc   2520

ataaagcaac agtggtaaac aacaaaaaga agggaaaagg cacaaatagt agtgatagtg   2580

aagaactttc agctggtgaa agtataacta agagtcagcc agtcaaatca gtttccactg   2640

gaatgaagtc tcatagtacc aaatctcccg caaggacgca gtctccagga aaatgtggaa   2700

agaatggtga taaggatcct gatctcaagg aacccagtaa tcgattaccc aaagtttaca   2760

aatggagttt tcagatgtcg gacctggaaa atatgacaag tgccgaacgc atcacaattc   2820

ttcaagaaaa acttcaagaa atcagaaaac attatctgtc attaaaatct gaagtagctt   2880

ccattgatcg gaggagaaag cgtttaaaga agaaagagag agaaagtgct gctacatcct   2940

catcctcctc ttcaccttca tccagttcca taacagctgc tgttatgtta actttagctg   3000

aaccgtcaat gtccagcgca tcacaaaatg gaatgcttca accactccca gaagacgtcc   3060

ttcactccca aaatgaggct tttctgaaac ggcgaggacc accaaccgac ggcgacaaac   3120

ctgctccctc acccagcgcc tcccttcgcc gccgcccggc ggccgactgc cggaggggag   3180

ggggcgtggc cagagagcgg aagtgcccgg aacccggaag tgcgagctgg cgcgcagctg   3240

cagtctggga gtctttggag taagaatggc cttggaaggg atgagcaaac ggaagagaaa   3300

gagaagtgtc caggagggag agaatcctga cgacggcgtt cgcgggagtc cgccggaaga   3360

ctacaggctt ggacaggtcg ccagtagctt atttcgcggc gaacaccatt ccagaggtgg   3420

caccggtcgg ctggcgtccc tcttcagttc tctggagccc cagattcaac ccgtgtacgt   3480

gcctgtgcct aaacaaacca tcaaaaaaac gaaacggaat gaggaggaag aaagtacatc   3540

ccagattgaa agaccacttt cgcaagaacc tgccaaaaaa gtgaaagcga agaagaaaca   3600

cactaacgca gaaaaaaagt tggcagacag ggaaagcgct ctagcgagtg ctgatttaga   3660

agaagaaatt caccagaaac aagggcagaa aaggaaaaat tctcaacctg gtgttaaagt   3720

agcagataga aaaatacttg atgacacaga agacacagtt gtcagtcaaa gaaagaaaat   3780

tcaaatcaac caagaagaag agagattaaa gaatgagaga actgtgtttg ttgggaattt   3840

gcctgttaca tgtaataaga agaagctgaa gtcgtttttt aaagagtatg gacaaataga   3900

atctgtacga tttcgttctc tgattccagc agagggaacg ctatccaaaa agttggcagc   3960

aataaaacgt aaaattcatc ctgatcagaa aaatattaat gcctatgttg tgtttaagga   4020

ggagagtgct gccacgcaag cattgaaaag aaatggggcc cagattgcag atggatttcg   4080

tattagagtt gatctcgcat ctgagacctc atctagagac aagagatcgg tttttgtggg   4140

gaatctccct tataaagttg aagaatctgc cattgagaag cactttctgg actgtggaag   4200

tatcatggcc gtgaggattg tgagagacaa aatgacaggc atcggcaaag ggtttggcta   4260

tgtgctcttt gagaatacag attctgttca tcttgctctg aaattaaata attctgaact   4320

catggggaga aaactcagag tcatgcgttc tgttaataaa gaaaaattta aacaacaaaa   4380

ttcaaatcca cgattgaaga atgtcagtaa acctaagcag ggacttaatt ttacttccaa   4440

aactgcagaa ggacatccta aaagcttatt tattggagaa aaagctgttc tccttaaaac   4500

gaagaagaaa ggacagaaga aaagtggacg ccctaagaaa cagagaaaac agaaataaca   4560

accaggaact gctttttctt ttcctgctga gtactgctaa taaaagtgct attatctgct   4620

gatagcatcg tctgct                                                   4636


<210>  7412
<211>  977
<212>  PRT
<213>  Homosapiens

<400>  7412

Met Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr 
1               5                   10                  15      


Arg Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly 
            20                  25                  30          


Gly Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln 
        35                  40                  45              


Asp Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys 
    50                  55                  60                  


Cys Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser 
65                  70                  75                  80  


Ala Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys 
                85                  90                  95      


Gln Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu 
            100                 105                 110         


Asn Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile 
        115                 120                 125             


Ile Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu 
    130                 135                 140                 


Asn Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile 
145                 150                 155                 160 


Pro Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu 
                165                 170                 175     


Asp Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp 
            180                 185                 190         


Glu Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser 
        195                 200                 205             


Gly Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile Val Arg Pro Ala Asp 
    210                 215                 220                 


Lys Asn Val Pro Lys Ile Lys His Arg Lys Lys Ile Lys Asn Lys Leu 
225                 230                 235                 240 


Asp Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser Pro Lys Asn Cys Lys 
                245                 250                 255     


Leu Arg Arg Leu Ser Lys Pro Pro Phe Gln Thr Asn Pro Ser Pro Glu 
            260                 265                 270         


Met Val Ser Lys Leu Asp Leu Thr Asp Ala Lys Asn Ser Asp Thr Ala 
        275                 280                 285             


His Ile Lys Ser Ile Glu Ile Thr Ser Ile Leu Asn Gly Leu Gln Ala 
    290                 295                 300                 


Ser Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu Asp Glu Arg Gly Ala 
305                 310                 315                 320 


Gln Asp Met Asp Asn Asn Gly Lys Glu Glu Ser Lys Ile Asp His Leu 
                325                 330                 335     


Thr Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu Glu Gln Asn Ser Ser 
            340                 345                 350         


Ser Leu Leu Glu Glu Asn Lys Val His Ala Asp Leu Val Ile Ser Lys 
        355                 360                 365             


Pro Val Ser Lys Ser Pro Glu Arg Leu Arg Lys Asp Ile Glu Val Leu 
    370                 375                 380                 


Ser Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val Thr Lys Lys Arg Lys 
385                 390                 395                 400 


Asp Val Lys Lys Asp Thr Thr Asp Lys Ser Ser Lys Pro Gln Ile Lys 
                405                 410                 415     


Arg Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu Cys Leu Lys Thr Gly 
            420                 425                 430         


Ser Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn Lys Glu Ser Leu Cys 
        435                 440                 445             


Met Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu Asp Glu Glu Glu Thr 
    450                 455                 460                 


Lys Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn Gly Leu Glu Glu Lys 
465                 470                 475                 480 


Arg Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser Gly Phe Ser Glu Val 
                485                 490                 495     


Ala Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser Asp Glu Arg Leu Gln 
            500                 505                 510         


Asn Ser Arg Ala Lys Asp Arg Lys Asp Val Trp Ser Ser Ile Gln Gly 
        515                 520                 525             


Gln Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe Ser Asp Ser Asp Thr 
    530                 535                 540                 


Glu Ala Ala Ala Ser Pro Pro His Pro Ala Pro Glu Glu Gly Val Ala 
545                 550                 555                 560 


Glu Glu Ser Leu Gln Thr Val Ala Glu Glu Glu Ser Cys Ser Pro Ser 
                565                 570                 575     


Val Glu Leu Glu Lys Pro Pro Pro Val Asn Val Asp Ser Lys Pro Ile 
            580                 585                 590         


Glu Glu Lys Thr Val Glu Val Asn Asp Arg Lys Ala Glu Phe Pro Ser 
        595                 600                 605             


Ser Gly Ser Asn Ser Val Leu Asn Thr Pro Pro Thr Thr Pro Glu Ser 
    610                 615                 620                 


Pro Ser Ser Val Thr Val Thr Glu Gly Ser Arg Gln Gln Ser Ser Val 
625                 630                 635                 640 


Thr Val Ser Glu Pro Leu Ala Pro Asn Gln Glu Glu Val Arg Ser Ile 
                645                 650                 655     


Lys Ser Glu Thr Asp Ser Thr Ile Glu Val Asp Ser Val Ala Gly Glu 
            660                 665                 670         


Leu Gln Asp Leu Gln Ser Glu Gly Asn Ser Ser Pro Ala Gly Phe Asp 
        675                 680                 685             


Ala Ser Val Ser Ser Ser Ser Ser Asn Gln Pro Glu Pro Glu His Pro 
    690                 695                 700                 


Glu Lys Ala Cys Thr Gly Gln Lys Arg Val Lys Asp Ala Gln Gly Gly 
705                 710                 715                 720 


Gly Ser Ser Ser Lys Lys Gln Lys Arg Ser His Lys Ala Thr Val Val 
                725                 730                 735     


Asn Asn Lys Lys Lys Gly Lys Gly Thr Asn Ser Ser Asp Ser Glu Glu 
            740                 745                 750         


Leu Ser Ala Gly Glu Ser Ile Thr Lys Ser Gln Pro Val Lys Ser Val 
        755                 760                 765             


Ser Thr Gly Met Lys Ser His Ser Thr Lys Ser Pro Ala Arg Thr Gln 
    770                 775                 780                 


Ser Pro Gly Lys Cys Gly Lys Asn Gly Asp Lys Asp Pro Asp Leu Lys 
785                 790                 795                 800 


Glu Pro Ser Asn Arg Leu Pro Lys Val Tyr Lys Trp Ser Phe Gln Met 
                805                 810                 815     


Ser Asp Leu Glu Asn Met Thr Ser Ala Glu Arg Ile Thr Ile Leu Gln 
            820                 825                 830         


Glu Lys Leu Gln Glu Ile Arg Lys His Tyr Leu Ser Leu Lys Ser Glu 
        835                 840                 845             


Val Ala Ser Ile Asp Arg Arg Arg Lys Arg Leu Lys Lys Lys Glu Arg 
    850                 855                 860                 


Glu Ser Ala Ala Thr Ser Ser Ser Ser Ser Ser Pro Ser Ser Ser Ser 
865                 870                 875                 880 


Ile Thr Ala Ala Val Met Leu Thr Leu Ala Glu Pro Ser Met Ser Ser 
                885                 890                 895     


Ala Ser Gln Asn Gly Met Leu Gln Pro Leu Pro Glu Asp Val Leu His 
            900                 905                 910         


Ser Gln Asn Glu Ala Phe Leu Lys Arg Arg Gly Pro Pro Thr Asp Gly 
        915                 920                 925             


Asp Lys Pro Ala Pro Ser Pro Ser Ala Ser Leu Arg Arg Arg Pro Ala 
    930                 935                 940                 


Ala Asp Cys Arg Arg Gly Gly Gly Val Ala Arg Glu Arg Lys Cys Pro 
945                 950                 955                 960 


Glu Pro Gly Ser Ala Ser Trp Arg Ala Ala Ala Val Trp Glu Ser Leu 
                965                 970                 975     


Glu 
    


<210>  7413
<211>  4894
<212>  DNA
<213>  Homosapiens

<400>  7413
gcggagggag actcttgagc ttcatcttgc cgccgccacg gccaccgcct ggacctttgc     60

ccggagggag ctgcagaggg tccatcgccg ccgtcctctg gagggcagcg cgattggggg    120

cccggacctc cagtccgggg gggatttttc gtcgtccccc tccccccaac cagggagccc    180

gagcggccgc caaacaaagg taccagtcgc cgccgcggga ggaggaagat gatgaaaaag    240

aaaaggagga taatagcagt gaagaagaag aagaaataga accatttcca gaagaaaggg    300

agaactttct tcagcaattg tacaaattta tggaagatag aggtacacct attaacaaac    360

gacctgtact tggatatcga aatttgaatc tctttaagtt attcagactt gtacacaaac    420

ttggaggatt tgataatatt gaaagtggag ctgtttggaa acaagtctac caagatcttg    480

gaatccctgt cttaaattca gctgcaggat acaatgttaa atgtgcttat aaaaaatact    540

tatatggttt tgaggagtac tgtagatcag ccaacattga atttcagatg gcattgccag    600

agaaagttgt taacaagcaa tgtaaggagt gtgaaaatgt aaaagaaata aaagttaagg    660

aggaaaatga aacagagatc aaagaaataa agatggagga ggagaggaat ataataccaa    720

gagaagaaaa gcctattgag gatgaaattg aaagaaaaga aaatattaag ccctctctgg    780

gaagtaaaaa gaatttatta gaatctatac ctacacattc tgatcaggaa aaagaagtta    840

acattaaaaa accagaagac aatgaaaatc tggatgacaa agatgatgac acaactaggg    900

tagatgaatc cctcaacata aaggtagaag ctgaggaaga aaaagcaaaa tctggagatg    960

aaacgaataa agaagaagat gaagatgatg aagaagcaga agaggaggag gaggaggaag   1020

aagaagaaga ggatgaagat gatgatgaca acaatgagga agaggagttt gagtgctatc   1080

caccaggcat gaaagtccaa gtgcggtatg gacgagggaa aaatcaaaaa atgtatgaag   1140

ctagtattaa agattctgat gtcgaaggtg gagaggtcct ttacttggtg cattactgcg   1200

gatggaatgt gagatacgat gaatggatta aagcagataa aatagtaaga cctgctgata   1260

aaaatgtgcc aaagataaaa catcggaaga aaataaagaa taaattagac aaagaaaaag   1320

acaaagatga aaaatactct ccaaaaaact gtaaacttcg gcgcttgtcc aaaccaccat   1380

ttcagacaaa tccatctcct gaaatggtat ccaaactgga tctcactgat gccaaaaact   1440

ctgatactgc tcatattaag tccatagaaa ttacttcgat ccttaatgga cttcaagctt   1500

ctgaaagttc tgctgaagac agtgagcagg aagatgagag aggtgctcaa gacatggata   1560

ataatggcaa agaggaatct aagattgatc atttgaccaa caacagaaat gatcttattt   1620

caaaggagga acagaacagt tcatctttgc tagaagaaaa caaagttcat gcagatttgg   1680

taatatccaa accagtgtca aaatctccag aaagattaag gaaagatata gaagtattat   1740

ccgaagatac tgattatgaa gaagatgaag tcacaaaaaa gagaaaggat gtcaagaagg   1800

acacaacaga taaatcttca aaaccacaaa taaaacgtgg taaaagaagg tattgcaata   1860

cagaagagtg tctaaaaact ggatcacctg gcaaaaagga agagaaggcc aagaacaaag   1920

aatcactttg catggaaaac agtagcaaca gctcttcaga tgaagatgaa gaagaaacaa   1980

aagcaaagat gacaccaact aagaaataca atggtttgga ggaaaaaaga aaatctctac   2040

ggacaactgg tttctattca ggattttcag aagtggcaga aaaaaggatt aaacttttaa   2100

ataactctga tgaaagactt caaaacagca gggccaaaga tcgaaaagat gtctggtcaa   2160

gtattcaggg acagtggcct aaaaaaacgc tgaaagagct tttttcagac tctgatactg   2220

aggctgcagc ttccccaccg catcctgccc cagaggaggg ggtggcagag gagtcactgc   2280

agactgtggc tgaagaggag agttgttcac ccagtgtaga actagaaaaa ccacctccag   2340

tcaatgtcga tagtaaaccc attgaagaaa aaacagtaga ggtcaatgac agaaaagcag   2400

aatttccaag tagtggcagt aattcagtgc taaatacccc tcctactaca cctgaatcgc   2460

cttcatcagt cactgtaaca gaaggcagcc ggcagcagtc ttctgtaaca gtatcagaac   2520

cactggctcc aaaccaagaa gaggttcgaa gtatcaagag tgaaactgat agcacaattg   2580

aggtggatag tgttgctggg gagctccaag acctccagtc tgaagggaat agctcgccag   2640

caggttttga tgccagtgtg agctcaagca gtagtaatca gccagaacca gaacatcctg   2700

aaaaagcctg tacaggtcag aaaagagtga aagatgctca gggaggagga agttcatcaa   2760

aaaagcagaa aagaagccat aaagcaacag tggtaaacaa caaaaagaag ggaaaaggca   2820

caaatagtag tgatagtgaa gaactttcag ctggtgaaag tataactaag agtcagccag   2880

tcaaatcagt ttccactgga atgaagtctc atagtaccaa atctcccgca aggacgcagt   2940

ctccaggaaa atgtggaaag aatggtgata aggatcctga tctcaaggaa cccagtaatc   3000

gattacccaa agtttacaaa tggagttttc agatgtcgga cctggaaaat atgacaagtg   3060

ccgaacgcat cacaattctt caagaaaaac ttcaagaaat cagaaaacat tatctgtcat   3120

taaaatctga agtagcttcc attgatcgga ggagaaagcg tttaaagaag aaagagagag   3180

aaagtgctgc tacatcctca tcctcctctt caccttcatc cagttccata acagctgctg   3240

ttatgttaac tttagctgaa ccgtcaatgt ccagcgcatc acaaaatgga atgcttcaac   3300

cactcccaga agacgtcctt cactcccaaa atgaggcttt tctgaaacgg cgaggaccac   3360

caaccgacgg cgacaaacct gctccctcac ccagcgcctc ccttcgccgc cgcccggcgg   3420

ccgactgccg gaggggaggg ggcgtggcca gagagcggaa gtgcccggaa cccggaagtg   3480

cgagctggcg cgcagctgca gtctgggagt ctttggagta agaatggcct tggaagggat   3540

gagcaaacgg aagagaaaga gaagtgtcca ggagggagag aatcctgacg acggcgttcg   3600

cgggagtccg ccggaagact acaggcttgg acaggtcgcc agtagcttat ttcgcggcga   3660

acaccattcc agaggtggca ccggtcggct ggcgtccctc ttcagttctc tggagcccca   3720

gattcaaccc gtgtacgtgc ctgtgcctaa acaaaccatc aaaaaaacga aacggaatga   3780

ggaggaagaa agtacatccc agattgaaag accactttcg caagaacctg ccaaaaaagt   3840

gaaagcgaag aagaaacaca ctaacgcaga aaaaaagttg gcagacaggg aaagcgctct   3900

agcgagtgct gatttagaag aagaaattca ccagaaacaa gggcagaaaa ggaaaaattc   3960

tcaacctggt gttaaagtag cagatagaaa aatacttgat gacacagaag acacagttgt   4020

cagtcaaaga aagaaaattc aaatcaacca agaagaagag agattaaaga atgagagaac   4080

tgtgtttgtt gggaatttgc ctgttacatg taataagaag aagctgaagt cgttttttaa   4140

agagtatgga caaatagaat ctgtacgatt tcgttctctg attccagcag agggaacgct   4200

atccaaaaag ttggcagcaa taaaacgtaa aattcatcct gatcagaaaa atattaatgc   4260

ctatgttgtg tttaaggagg agagtgctgc cacgcaagca ttgaaaagaa atggggccca   4320

gattgcagat ggatttcgta ttagagttga tctcgcatct gagacctcat ctagagacaa   4380

gagatcggtt tttgtgggga atctccctta taaagttgaa gaatctgcca ttgagaagca   4440

ctttctggac tgtggaagta tcatggccgt gaggattgtg agagacaaaa tgacaggcat   4500

cggcaaaggg tttggctatg tgctctttga gaatacagat tctgttcatc ttgctctgaa   4560

attaaataat tctgaactca tggggagaaa actcagagtc atgcgttctg ttaataaaga   4620

aaaatttaaa caacaaaatt caaatccacg attgaagaat gtcagtaaac ctaagcaggg   4680

acttaatttt acttccaaaa ctgcagaagg acatcctaaa agcttattta ttggagaaaa   4740

agctgttctc cttaaaacga agaagaaagg acagaagaaa agtggacgcc ctaagaaaca   4800

gagaaaacag aaataacaac caggaactgc tttttctttt cctgctgagt actgctaata   4860

aaagtgctat tatctgctga tagcatcgtc tgct                               4894


<210>  7414
<211>  1063
<212>  PRT
<213>  Homosapiens

<400>  7414

Met Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr 
1               5                   10                  15      


Arg Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly 
            20                  25                  30          


Gly Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln 
        35                  40                  45              


Asp Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys 
    50                  55                  60                  


Cys Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser 
65                  70                  75                  80  


Ala Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys 
                85                  90                  95      


Gln Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu 
            100                 105                 110         


Asn Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile 
        115                 120                 125             


Ile Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu 
    130                 135                 140                 


Asn Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile 
145                 150                 155                 160 


Pro Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu 
                165                 170                 175     


Asp Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp 
            180                 185                 190         


Glu Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser 
        195                 200                 205             


Gly Asp Glu Thr Asn Lys Glu Glu Asp Glu Asp Asp Glu Glu Ala Glu 
    210                 215                 220                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Asp 
225                 230                 235                 240 


Asn Asn Glu Glu Glu Glu Phe Glu Cys Tyr Pro Pro Gly Met Lys Val 
                245                 250                 255     


Gln Val Arg Tyr Gly Arg Gly Lys Asn Gln Lys Met Tyr Glu Ala Ser 
            260                 265                 270         


Ile Lys Asp Ser Asp Val Glu Gly Gly Glu Val Leu Tyr Leu Val His 
        275                 280                 285             


Tyr Cys Gly Trp Asn Val Arg Tyr Asp Glu Trp Ile Lys Ala Asp Lys 
    290                 295                 300                 


Ile Val Arg Pro Ala Asp Lys Asn Val Pro Lys Ile Lys His Arg Lys 
305                 310                 315                 320 


Lys Ile Lys Asn Lys Leu Asp Lys Glu Lys Asp Lys Asp Glu Lys Tyr 
                325                 330                 335     


Ser Pro Lys Asn Cys Lys Leu Arg Arg Leu Ser Lys Pro Pro Phe Gln 
            340                 345                 350         


Thr Asn Pro Ser Pro Glu Met Val Ser Lys Leu Asp Leu Thr Asp Ala 
        355                 360                 365             


Lys Asn Ser Asp Thr Ala His Ile Lys Ser Ile Glu Ile Thr Ser Ile 
    370                 375                 380                 


Leu Asn Gly Leu Gln Ala Ser Glu Ser Ser Ala Glu Asp Ser Glu Gln 
385                 390                 395                 400 


Glu Asp Glu Arg Gly Ala Gln Asp Met Asp Asn Asn Gly Lys Glu Glu 
                405                 410                 415     


Ser Lys Ile Asp His Leu Thr Asn Asn Arg Asn Asp Leu Ile Ser Lys 
            420                 425                 430         


Glu Glu Gln Asn Ser Ser Ser Leu Leu Glu Glu Asn Lys Val His Ala 
        435                 440                 445             


Asp Leu Val Ile Ser Lys Pro Val Ser Lys Ser Pro Glu Arg Leu Arg 
    450                 455                 460                 


Lys Asp Ile Glu Val Leu Ser Glu Asp Thr Asp Tyr Glu Glu Asp Glu 
465                 470                 475                 480 


Val Thr Lys Lys Arg Lys Asp Val Lys Lys Asp Thr Thr Asp Lys Ser 
                485                 490                 495     


Ser Lys Pro Gln Ile Lys Arg Gly Lys Arg Arg Tyr Cys Asn Thr Glu 
            500                 505                 510         


Glu Cys Leu Lys Thr Gly Ser Pro Gly Lys Lys Glu Glu Lys Ala Lys 
        515                 520                 525             


Asn Lys Glu Ser Leu Cys Met Glu Asn Ser Ser Asn Ser Ser Ser Asp 
    530                 535                 540                 


Glu Asp Glu Glu Glu Thr Lys Ala Lys Met Thr Pro Thr Lys Lys Tyr 
545                 550                 555                 560 


Asn Gly Leu Glu Glu Lys Arg Lys Ser Leu Arg Thr Thr Gly Phe Tyr 
                565                 570                 575     


Ser Gly Phe Ser Glu Val Ala Glu Lys Arg Ile Lys Leu Leu Asn Asn 
            580                 585                 590         


Ser Asp Glu Arg Leu Gln Asn Ser Arg Ala Lys Asp Arg Lys Asp Val 
        595                 600                 605             


Trp Ser Ser Ile Gln Gly Gln Trp Pro Lys Lys Thr Leu Lys Glu Leu 
    610                 615                 620                 


Phe Ser Asp Ser Asp Thr Glu Ala Ala Ala Ser Pro Pro His Pro Ala 
625                 630                 635                 640 


Pro Glu Glu Gly Val Ala Glu Glu Ser Leu Gln Thr Val Ala Glu Glu 
                645                 650                 655     


Glu Ser Cys Ser Pro Ser Val Glu Leu Glu Lys Pro Pro Pro Val Asn 
            660                 665                 670         


Val Asp Ser Lys Pro Ile Glu Glu Lys Thr Val Glu Val Asn Asp Arg 
        675                 680                 685             


Lys Ala Glu Phe Pro Ser Ser Gly Ser Asn Ser Val Leu Asn Thr Pro 
    690                 695                 700                 


Pro Thr Thr Pro Glu Ser Pro Ser Ser Val Thr Val Thr Glu Gly Ser 
705                 710                 715                 720 


Arg Gln Gln Ser Ser Val Thr Val Ser Glu Pro Leu Ala Pro Asn Gln 
                725                 730                 735     


Glu Glu Val Arg Ser Ile Lys Ser Glu Thr Asp Ser Thr Ile Glu Val 
            740                 745                 750         


Asp Ser Val Ala Gly Glu Leu Gln Asp Leu Gln Ser Glu Gly Asn Ser 
        755                 760                 765             


Ser Pro Ala Gly Phe Asp Ala Ser Val Ser Ser Ser Ser Ser Asn Gln 
    770                 775                 780                 


Pro Glu Pro Glu His Pro Glu Lys Ala Cys Thr Gly Gln Lys Arg Val 
785                 790                 795                 800 


Lys Asp Ala Gln Gly Gly Gly Ser Ser Ser Lys Lys Gln Lys Arg Ser 
                805                 810                 815     


His Lys Ala Thr Val Val Asn Asn Lys Lys Lys Gly Lys Gly Thr Asn 
            820                 825                 830         


Ser Ser Asp Ser Glu Glu Leu Ser Ala Gly Glu Ser Ile Thr Lys Ser 
        835                 840                 845             


Gln Pro Val Lys Ser Val Ser Thr Gly Met Lys Ser His Ser Thr Lys 
    850                 855                 860                 


Ser Pro Ala Arg Thr Gln Ser Pro Gly Lys Cys Gly Lys Asn Gly Asp 
865                 870                 875                 880 


Lys Asp Pro Asp Leu Lys Glu Pro Ser Asn Arg Leu Pro Lys Val Tyr 
                885                 890                 895     


Lys Trp Ser Phe Gln Met Ser Asp Leu Glu Asn Met Thr Ser Ala Glu 
            900                 905                 910         


Arg Ile Thr Ile Leu Gln Glu Lys Leu Gln Glu Ile Arg Lys His Tyr 
        915                 920                 925             


Leu Ser Leu Lys Ser Glu Val Ala Ser Ile Asp Arg Arg Arg Lys Arg 
    930                 935                 940                 


Leu Lys Lys Lys Glu Arg Glu Ser Ala Ala Thr Ser Ser Ser Ser Ser 
945                 950                 955                 960 


Ser Pro Ser Ser Ser Ser Ile Thr Ala Ala Val Met Leu Thr Leu Ala 
                965                 970                 975     


Glu Pro Ser Met Ser Ser Ala Ser Gln Asn Gly Met Leu Gln Pro Leu 
            980                 985                 990         


Pro Glu Asp Val Leu His Ser Gln  Asn Glu Ala Phe Leu  Lys Arg Arg 
        995                 1000                 1005             


Gly Pro  Pro Thr Asp Gly Asp  Lys Pro Ala Pro Ser  Pro Ser Ala 
    1010                 1015                 1020             


Ser Leu  Arg Arg Arg Pro Ala  Ala Asp Cys Arg Arg  Gly Gly Gly 
    1025                 1030                 1035             


Val Ala  Arg Glu Arg Lys Cys  Pro Glu Pro Gly Ser  Ala Ser Trp 
    1040                 1045                 1050             


Arg Ala  Ala Ala Val Trp Glu  Ser Leu Glu 
    1055                 1060             


<210>  7415
<211>  5982
<212>  DNA
<213>  Homosapiens

<400>  7415
gtttgcccgt cagtcgagtc cggagtgagg agctcggtcg ccgaagcgga gggagactct     60

tgagcttcat cttgccgccg ccacggccac cgcctggacc tttgcccgga gggagctgca    120

gagggtccat cgccgccgtc ctctggaggg cagcgcgatt gggggcccgg acctccagtc    180

cgggggggat ttttcgtcgt ccccctcccc ccaaccaggg agcccgagcg gccgccaaac    240

aaaggtacca gtcgccgccg cgggaggagg aggagccgga gcctctgcct cagcagccgc    300

tggacccgcc gcccttcttc cccatctctc ccccgggcct gctggttttg ggggggagaa    360

ggagagaggg gactctggac gtgccagggt cagatctcgc ctccgaggaa ggtgcagctg    420

aacctggtgt tttagaggat accttggtcc cagagtcatc atgaaggccc ttgatgagcc    480

tccctatttg acagtgggca ctgatgtgag tgctaaatac agaggagcct tttgtgaagc    540

caagatcaag acagcaaaaa gacttgtcaa agtcaaggtg acatttagac atgattcttc    600

aacagtggaa gttcaggatg accacataaa gggcccacta aaggtaggag ctattgtgga    660

agtgaagaat cttgatggtg catatcagga agctgttatc aataaactaa cagatgcgag    720

ttggtacact gtagtttttg atgacggaga tgagaagaca ctgagacgat cttcactgtg    780

cctgaaagga gagaggcatt ttgctgaaag tgaaacatta gaccagctcc cactcaccaa    840

ccctgagcat tttggcactc cagtcatagg aaagaaaaca aatagaggaa gaagatctaa    900

tcatatacca gaggaagagt cttcatcatc ctccagtgat gaagatgagg atgataggaa    960

acagattgat gagctactag gcaaagttgt atgtgtagat tacattagtt tggataaaaa   1020

gaaagcactg tggtttcctg cattggtggt ttgtcctgat tgtagtgatg agattgctgt   1080

aaaaaaggac aatattcttg ttcgatcttt caaagatgga aaatttactt cagttccaag   1140

aaaagatgtc catgaaatta ctagtgacac tgcaccaaag cctgatgctg ttttaaagca   1200

agcctttgaa caggcacttg aatttcacaa aagtagaact attcctgcta actggaagac   1260

tgaattgaaa gaagatagct ctagcagtga agcagaggaa gaagaggagg aggaagatga   1320

tgaaaaagaa aaggaggata atagcagtga agaagaagaa gaaatagaac catttccaga   1380

agaaagggag aactttcttc agcaattgta caaatttatg gaagatagag gtacacctat   1440

taacaaacga cctgtacttg gatatcgaaa tttgaatctc tttaagttat tcagacttgt   1500

acacaaactt ggaggatttg ataatattga aagtggagct gtttggaaac aagtctacca   1560

agatcttgga atccctgtct taaattcagc tgcaggatac aatgttaaat gtgcttataa   1620

aaaatactta tatggttttg aggagtactg tagatcagcc aacattgaat ttcagatggc   1680

attgccagag aaagttgtta acaagcaatg taaggagtgt gaaaatgtaa aagaaataaa   1740

agttaaggag gaaaatgaaa cagagatcaa agaaataaag atggaggagg agaggaatat   1800

aataccaaga gaagaaaagc ctattgagga tgaaattgaa agaaaagaaa atattaagcc   1860

ctctctggga agtaaaaaga atttattaga atctatacct acacattctg atcaggaaaa   1920

agaagttaac attaaaaaac cagaagacaa tgaaaatctg gatgacaaag atgatgacac   1980

aactagggta gatgaatccc tcaacataaa ggtagaagct gaggaagaaa aagcaaaatc   2040

tggagatgaa acgaataaag aagaagatga agatgatgaa gaagcagaag aggaggagga   2100

ggaggaagaa gaagaagagg atgaagatga tgatgacaac aatgaggaag aggagtttga   2160

gtgctatcca ccaggcatga aagtccaagt gcggtatgga cgagggaaaa atcaaaaaat   2220

gtatgaagct agtattaaag attctgatgt cgaaggtgga gaggtccttt acttggtgca   2280

ttactgcgga tggaatgtga gatacgatga atggattaaa gcagataaaa tagtaagacc   2340

tgctgataaa aatgtgccaa agataaaaca tcggaagaaa ataaagaata aattagacaa   2400

agaaaaagac aaagatgaaa aatactctcc aaaaaactgt aaacttcggc gcttgtccaa   2460

accaccattt cagacaaatc catctcctga aatggtatcc aaactggatc tcactgatgc   2520

caaaaactct gatactgctc atattaagtc catagaaatt acttcgatcc ttaatggact   2580

tcaagcttct gaaagttctg ctgaagacag tgagcaggaa gatgagagag gtgctcaaga   2640

catggataat aatggcaaag aggaatctaa gattgatcat ttgaccaaca acagaaatga   2700

tcttatttca aaggaggaac agaacagttc atctttgcta gaagaaaaca aagttcatgc   2760

agatttggta atatccaaac cagtgtcaaa atctccagaa agattaagga aagatataga   2820

agtattatcc gaagatactg attatgaaga agatgaagtc acaaaaaaga gaaaggatgt   2880

caagaaggac acaacagata aatcttcaaa accacaaata aaacgtggta aaagaaggta   2940

ttgcaataca gaagagtgtc taaaaactgg atcacctggc aaaaaggaag agaaggccaa   3000

gaacaaagaa tcactttgca tggaaaacag tagcaacagc tcttcagatg aagatgaaga   3060

agaaacaaaa gcaaagatga caccaactaa gaaatacaat ggtttggagg aaaaaagaaa   3120

atctctacgg acaactggtt tctattcagg attttcagaa gtggcagaaa aaaggattaa   3180

acttttaaat aactctgatg aaagacttca aaacagcagg gccaaagatc gaaaagatgt   3240

ctggtcaagt attcagggac agtggcctaa aaaaacgctg aaagagcttt tttcagactc   3300

tgatactgag gctgcagctt ccccaccgca tcctgcccca gaggaggggg tggcagagga   3360

gtcactgcag actgtggctg aagaggagag ttgttcaccc agtgtagaac tagaaaaacc   3420

acctccagtc aatgtcgata gtaaacccat tgaagaaaaa acagtagagg tcaatgacag   3480

aaaagcagaa tttccaagta gtggcagtaa ttcagtgcta aatacccctc ctactacacc   3540

tgaatcgcct tcatcagtca ctgtaacaga aggcagccgg cagcagtctt ctgtaacagt   3600

atcagaacca ctggctccaa accaagaaga ggttcgaagt atcaagagtg aaactgatag   3660

cacaattgag gtggatagtg ttgctgggga gctccaagac ctccagtctg aagggaatag   3720

ctcgccagca ggttttgatg ccagtgtgag ctcaagcagt agtaatcagc cagaaccaga   3780

acatcctgaa aaagcctgta caggtcagaa aagagtgaaa gatgctcagg gaggaggaag   3840

ttcatcaaaa aagcagaaaa gaagccataa agcaacagtg gtaaacaaca aaaagaaggg   3900

aaaaggcaca aatagtagtg atagtgaaga actttcagct ggtgaaagta taactaagag   3960

tcagccagtc aaatcagttt ccactggaat gaagtctcat agtaccaaat ctcccgcaag   4020

gacgcagtct ccaggaaaat gtggaaagaa tggtgataag gatcctgatc tcaaggaacc   4080

cagtaatcga ttacccaaag tttacaaatg gagttttcag atgtcggacc tggaaaatat   4140

gacaagtgcc gaacgcatca caattcttca agaaaaactt caagaaatca gaaaacatta   4200

tctgtcatta aaatctgaag tagcttccat tgatcggagg agaaagcgtt taaagaagaa   4260

agagagagaa agtgctgcta catcctcatc ctcctcttca ccttcatcca gttccataac   4320

agctgctgtt atgttaactt tagctgaacc gtcaatgtcc agcgcatcac aaaatggaat   4380

gcttcaacca ctcccagaag acgtccttca ctcccaaaat gaggcttttc tgaaacggcg   4440

aggaccacca accgacggcg acaaacctgc tccctcaccc agcgcctccc ttcgccgccg   4500

cccggcggcc gactgccgga ggggaggggg cgtggccaga gagcggaagt gcccggaacc   4560

cggaagtgcg agctggcgcg cagctgcagt ctgggagtct ttggagtaag aatggccttg   4620

gaagggatga gcaaacggaa gagaaagaga agtgtccagg agggagagaa tcctgacgac   4680

ggcgttcgcg ggagtccgcc ggaagactac aggcttggac aggtcgccag tagcttattt   4740

cgcggcgaac accattccag aggtggcacc ggtcggctgg cgtccctctt cagttctctg   4800

gagccccaga ttcaacccgt gtacgtgcct gtgcctaaac aaaccatcaa aaaaacgaaa   4860

cggaatgagg aggaagaaag tacatcccag attgaaagac cactttcgca agaacctgcc   4920

aaaaaagtga aagcgaagaa gaaacacact aacgcagaaa aaaagttggc agacagggaa   4980

agcgctctag cgagtgctga tttagaagaa gaaattcacc agaaacaagg gcagaaaagg   5040

aaaaattctc aacctggtgt taaagtagca gatagaaaaa tacttgatga cacagaagac   5100

acagttgtca gtcaaagaaa gaaaattcaa atcaaccaag aagaagagag attaaagaat   5160

gagagaactg tgtttgttgg gaatttgcct gttacatgta ataagaagaa gctgaagtcg   5220

ttttttaaag agtatggaca aatagaatct gtacgatttc gttctctgat tccagcagag   5280

ggaacgctat ccaaaaagtt ggcagcaata aaacgtaaaa ttcatcctga tcagaaaaat   5340

attaatgcct atgttgtgtt taaggaggag agtgctgcca cgcaagcatt gaaaagaaat   5400

ggggcccaga ttgcagatgg atttcgtatt agagttgatc tcgcatctga gacctcatct   5460

agagacaaga gatcggtttt tgtggggaat ctcccttata aagttgaaga atctgccatt   5520

gagaagcact ttctggactg tggaagtatc atggccgtga ggattgtgag agacaaaatg   5580

acaggcatcg gcaaagggtt tggctatgtg ctctttgaga atacagattc tgttcatctt   5640

gctctgaaat taaataattc tgaactcatg gggagaaaac tcagagtcat gcgttctgtt   5700

aataaagaaa aatttaaaca acaaaattca aatccacgat tgaagaatgt cagtaaacct   5760

aagcagggac ttaattttac ttccaaaact gcagaaggac atcctaaaag cttatttatt   5820

ggagaaaaag ctgttctcct taaaacgaag aagaaaggac agaagaaaag tggacgccct   5880

aagaaacaga gaaaacagaa ataacaacca ggaactgctt tttcttttcc tgctgagtac   5940

tgctaataaa agtgctatta tctgctgata gcatcgtctg ct                      5982


<210>  7416
<211>  1382
<212>  PRT
<213>  Homosapiens

<400>  7416

Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Thr Val Gly Thr Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Thr Phe Arg His Asp Ser Ser Thr 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Thr Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro 
        115                 120                 125             


Glu His Phe Gly Thr Pro Val Ile Gly Lys Lys Thr Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Thr Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Thr Ser Asp Thr Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Thr Ile Pro Ala Asn Trp Lys Thr Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Asp Glu Thr Asn Lys Glu Glu Asp Glu Asp Asp Glu Glu Ala Glu Glu 
    530                 535                 540                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Asp Asn 
545                 550                 555                 560 


Asn Glu Glu Glu Glu Phe Glu Cys Tyr Pro Pro Gly Met Lys Val Gln 
                565                 570                 575     


Val Arg Tyr Gly Arg Gly Lys Asn Gln Lys Met Tyr Glu Ala Ser Ile 
            580                 585                 590         


Lys Asp Ser Asp Val Glu Gly Gly Glu Val Leu Tyr Leu Val His Tyr 
        595                 600                 605             


Cys Gly Trp Asn Val Arg Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile 
    610                 615                 620                 


Val Arg Pro Ala Asp Lys Asn Val Pro Lys Ile Lys His Arg Lys Lys 
625                 630                 635                 640 


Ile Lys Asn Lys Leu Asp Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser 
                645                 650                 655     


Pro Lys Asn Cys Lys Leu Arg Arg Leu Ser Lys Pro Pro Phe Gln Thr 
            660                 665                 670         


Asn Pro Ser Pro Glu Met Val Ser Lys Leu Asp Leu Thr Asp Ala Lys 
        675                 680                 685             


Asn Ser Asp Thr Ala His Ile Lys Ser Ile Glu Ile Thr Ser Ile Leu 
    690                 695                 700                 


Asn Gly Leu Gln Ala Ser Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu 
705                 710                 715                 720 


Asp Glu Arg Gly Ala Gln Asp Met Asp Asn Asn Gly Lys Glu Glu Ser 
                725                 730                 735     


Lys Ile Asp His Leu Thr Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu 
            740                 745                 750         


Glu Gln Asn Ser Ser Ser Leu Leu Glu Glu Asn Lys Val His Ala Asp 
        755                 760                 765             


Leu Val Ile Ser Lys Pro Val Ser Lys Ser Pro Glu Arg Leu Arg Lys 
    770                 775                 780                 


Asp Ile Glu Val Leu Ser Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val 
785                 790                 795                 800 


Thr Lys Lys Arg Lys Asp Val Lys Lys Asp Thr Thr Asp Lys Ser Ser 
                805                 810                 815     


Lys Pro Gln Ile Lys Arg Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu 
            820                 825                 830         


Cys Leu Lys Thr Gly Ser Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn 
        835                 840                 845             


Lys Glu Ser Leu Cys Met Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu 
    850                 855                 860                 


Asp Glu Glu Glu Thr Lys Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn 
865                 870                 875                 880 


Gly Leu Glu Glu Lys Arg Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser 
                885                 890                 895     


Gly Phe Ser Glu Val Ala Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser 
            900                 905                 910         


Asp Glu Arg Leu Gln Asn Ser Arg Ala Lys Asp Arg Lys Asp Val Trp 
        915                 920                 925             


Ser Ser Ile Gln Gly Gln Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe 
    930                 935                 940                 


Ser Asp Ser Asp Thr Glu Ala Ala Ala Ser Pro Pro His Pro Ala Pro 
945                 950                 955                 960 


Glu Glu Gly Val Ala Glu Glu Ser Leu Gln Thr Val Ala Glu Glu Glu 
                965                 970                 975     


Ser Cys Ser Pro Ser Val Glu Leu Glu Lys Pro Pro Pro Val Asn Val 
            980                 985                 990         


Asp Ser Lys Pro Ile Glu Glu Lys  Thr Val Glu Val Asn  Asp Arg Lys 
        995                 1000                 1005             


Ala Glu  Phe Pro Ser Ser Gly  Ser Asn Ser Val Leu  Asn Thr Pro 
    1010                 1015                 1020             


Pro Thr  Thr Pro Glu Ser Pro  Ser Ser Val Thr Val  Thr Glu Gly 
    1025                 1030                 1035             


Ser Arg  Gln Gln Ser Ser Val  Thr Val Ser Glu Pro  Leu Ala Pro 
    1040                 1045                 1050             


Asn Gln  Glu Glu Val Arg Ser  Ile Lys Ser Glu Thr  Asp Ser Thr 
    1055                 1060                 1065             


Ile Glu  Val Asp Ser Val Ala  Gly Glu Leu Gln Asp  Leu Gln Ser 
    1070                 1075                 1080             


Glu Gly  Asn Ser Ser Pro Ala  Gly Phe Asp Ala Ser  Val Ser Ser 
    1085                 1090                 1095             


Ser Ser  Ser Asn Gln Pro Glu  Pro Glu His Pro Glu  Lys Ala Cys 
    1100                 1105                 1110             


Thr Gly  Gln Lys Arg Val Lys  Asp Ala Gln Gly Gly  Gly Ser Ser 
    1115                 1120                 1125             


Ser Lys  Lys Gln Lys Arg Ser  His Lys Ala Thr Val  Val Asn Asn 
    1130                 1135                 1140             


Lys Lys  Lys Gly Lys Gly Thr  Asn Ser Ser Asp Ser  Glu Glu Leu 
    1145                 1150                 1155             


Ser Ala  Gly Glu Ser Ile Thr  Lys Ser Gln Pro Val  Lys Ser Val 
    1160                 1165                 1170             


Ser Thr  Gly Met Lys Ser His  Ser Thr Lys Ser Pro  Ala Arg Thr 
    1175                 1180                 1185             


Gln Ser  Pro Gly Lys Cys Gly  Lys Asn Gly Asp Lys  Asp Pro Asp 
    1190                 1195                 1200             


Leu Lys  Glu Pro Ser Asn Arg  Leu Pro Lys Val Tyr  Lys Trp Ser 
    1205                 1210                 1215             


Phe Gln  Met Ser Asp Leu Glu  Asn Met Thr Ser Ala  Glu Arg Ile 
    1220                 1225                 1230             


Thr Ile  Leu Gln Glu Lys Leu  Gln Glu Ile Arg Lys  His Tyr Leu 
    1235                 1240                 1245             


Ser Leu  Lys Ser Glu Val Ala  Ser Ile Asp Arg Arg  Arg Lys Arg 
    1250                 1255                 1260             


Leu Lys  Lys Lys Glu Arg Glu  Ser Ala Ala Thr Ser  Ser Ser Ser 
    1265                 1270                 1275             


Ser Ser  Pro Ser Ser Ser Ser  Ile Thr Ala Ala Val  Met Leu Thr 
    1280                 1285                 1290             


Leu Ala  Glu Pro Ser Met Ser  Ser Ala Ser Gln Asn  Gly Met Leu 
    1295                 1300                 1305             


Gln Pro  Leu Pro Glu Asp Val  Leu His Ser Gln Asn  Glu Ala Phe 
    1310                 1315                 1320             


Leu Lys  Arg Arg Gly Pro Pro  Thr Asp Gly Asp Lys  Pro Ala Pro 
    1325                 1330                 1335             


Ser Pro  Ser Ala Ser Leu Arg  Arg Arg Pro Ala Ala  Asp Cys Arg 
    1340                 1345                 1350             


Arg Gly  Gly Gly Val Ala Arg  Glu Arg Lys Cys Pro  Glu Pro Gly 
    1355                 1360                 1365             


Ser Ala  Ser Trp Arg Ala Ala  Ala Val Trp Glu Ser  Leu Glu 
    1370                 1375                 1380         


<210>  7417
<211>  5724
<212>  DNA
<213>  Homosapiens

<400>  7417
gtttgcccgt cagtcgagtc cggagtgagg agctcggtcg ccgaagcgga gggagactct     60

tgagcttcat cttgccgccg ccacggccac cgcctggacc tttgcccgga gggagctgca    120

gagggtccat cgccgccgtc ctctggaggg cagcgcgatt gggggcccgg acctccagtc    180

cgggggggat ttttcgtcgt ccccctcccc ccaaccaggg agcccgagcg gccgccaaac    240

aaaggtacca gtcgccgccg cgggaggagg aggagccgga gcctctgcct cagcagccgc    300

tggacccgcc gcccttcttc cccatctctc ccccgggcct gctggttttg ggggggagaa    360

ggagagaggg gactctggac gtgccagggt cagatctcgc ctccgaggaa ggtgcagctg    420

aacctggtgt tttagaggat accttggtcc cagagtcatc atgaaggccc ttgatgagcc    480

tccctatttg acagtgggca ctgatgtgag tgctaaatac agaggagcct tttgtgaagc    540

caagatcaag acagcaaaaa gacttgtcaa agtcaaggtg acatttagac atgattcttc    600

aacagtggaa gttcaggatg accacataaa gggcccacta aaggtaggag ctattgtgga    660

agtgaagaat cttgatggtg catatcagga agctgttatc aataaactaa cagatgcgag    720

ttggtacact gtagtttttg atgacggaga tgagaagaca ctgagacgat cttcactgtg    780

cctgaaagga gagaggcatt ttgctgaaag tgaaacatta gaccagctcc cactcaccaa    840

ccctgagcat tttggcactc cagtcatagg aaagaaaaca aatagaggaa gaagatctaa    900

tcatatacca gaggaagagt cttcatcatc ctccagtgat gaagatgagg atgataggaa    960

acagattgat gagctactag gcaaagttgt atgtgtagat tacattagtt tggataaaaa   1020

gaaagcactg tggtttcctg cattggtggt ttgtcctgat tgtagtgatg agattgctgt   1080

aaaaaaggac aatattcttg ttcgatcttt caaagatgga aaatttactt cagttccaag   1140

aaaagatgtc catgaaatta ctagtgacac tgcaccaaag cctgatgctg ttttaaagca   1200

agcctttgaa caggcacttg aatttcacaa aagtagaact attcctgcta actggaagac   1260

tgaattgaaa gaagatagct ctagcagtga agcagaggaa gaagaggagg aggaagatga   1320

tgaaaaagaa aaggaggata atagcagtga agaagaagaa gaaatagaac catttccaga   1380

agaaagggag aactttcttc agcaattgta caaatttatg gaagatagag gtacacctat   1440

taacaaacga cctgtacttg gatatcgaaa tttgaatctc tttaagttat tcagacttgt   1500

acacaaactt ggaggatttg ataatattga aagtggagct gtttggaaac aagtctacca   1560

agatcttgga atccctgtct taaattcagc tgcaggatac aatgttaaat gtgcttataa   1620

aaaatactta tatggttttg aggagtactg tagatcagcc aacattgaat ttcagatggc   1680

attgccagag aaagttgtta acaagcaatg taaggagtgt gaaaatgtaa aagaaataaa   1740

agttaaggag gaaaatgaaa cagagatcaa agaaataaag atggaggagg agaggaatat   1800

aataccaaga gaagaaaagc ctattgagga tgaaattgaa agaaaagaaa atattaagcc   1860

ctctctggga agtaaaaaga atttattaga atctatacct acacattctg atcaggaaaa   1920

agaagttaac attaaaaaac cagaagacaa tgaaaatctg gatgacaaag atgatgacac   1980

aactagggta gatgaatccc tcaacataaa ggtagaagct gaggaagaaa aagcaaaatc   2040

tggatacgat gaatggatta aagcagataa aatagtaaga cctgctgata aaaatgtgcc   2100

aaagataaaa catcggaaga aaataaagaa taaattagac aaagaaaaag acaaagatga   2160

aaaatactct ccaaaaaact gtaaacttcg gcgcttgtcc aaaccaccat ttcagacaaa   2220

tccatctcct gaaatggtat ccaaactgga tctcactgat gccaaaaact ctgatactgc   2280

tcatattaag tccatagaaa ttacttcgat ccttaatgga cttcaagctt ctgaaagttc   2340

tgctgaagac agtgagcagg aagatgagag aggtgctcaa gacatggata ataatggcaa   2400

agaggaatct aagattgatc atttgaccaa caacagaaat gatcttattt caaaggagga   2460

acagaacagt tcatctttgc tagaagaaaa caaagttcat gcagatttgg taatatccaa   2520

accagtgtca aaatctccag aaagattaag gaaagatata gaagtattat ccgaagatac   2580

tgattatgaa gaagatgaag tcacaaaaaa gagaaaggat gtcaagaagg acacaacaga   2640

taaatcttca aaaccacaaa taaaacgtgg taaaagaagg tattgcaata cagaagagtg   2700

tctaaaaact ggatcacctg gcaaaaagga agagaaggcc aagaacaaag aatcactttg   2760

catggaaaac agtagcaaca gctcttcaga tgaagatgaa gaagaaacaa aagcaaagat   2820

gacaccaact aagaaataca atggtttgga ggaaaaaaga aaatctctac ggacaactgg   2880

tttctattca ggattttcag aagtggcaga aaaaaggatt aaacttttaa ataactctga   2940

tgaaagactt caaaacagca gggccaaaga tcgaaaagat gtctggtcaa gtattcaggg   3000

acagtggcct aaaaaaacgc tgaaagagct tttttcagac tctgatactg aggctgcagc   3060

ttccccaccg catcctgccc cagaggaggg ggtggcagag gagtcactgc agactgtggc   3120

tgaagaggag agttgttcac ccagtgtaga actagaaaaa ccacctccag tcaatgtcga   3180

tagtaaaccc attgaagaaa aaacagtaga ggtcaatgac agaaaagcag aatttccaag   3240

tagtggcagt aattcagtgc taaatacccc tcctactaca cctgaatcgc cttcatcagt   3300

cactgtaaca gaaggcagcc ggcagcagtc ttctgtaaca gtatcagaac cactggctcc   3360

aaaccaagaa gaggttcgaa gtatcaagag tgaaactgat agcacaattg aggtggatag   3420

tgttgctggg gagctccaag acctccagtc tgaagggaat agctcgccag caggttttga   3480

tgccagtgtg agctcaagca gtagtaatca gccagaacca gaacatcctg aaaaagcctg   3540

tacaggtcag aaaagagtga aagatgctca gggaggagga agttcatcaa aaaagcagaa   3600

aagaagccat aaagcaacag tggtaaacaa caaaaagaag ggaaaaggca caaatagtag   3660

tgatagtgaa gaactttcag ctggtgaaag tataactaag agtcagccag tcaaatcagt   3720

ttccactgga atgaagtctc atagtaccaa atctcccgca aggacgcagt ctccaggaaa   3780

atgtggaaag aatggtgata aggatcctga tctcaaggaa cccagtaatc gattacccaa   3840

agtttacaaa tggagttttc agatgtcgga cctggaaaat atgacaagtg ccgaacgcat   3900

cacaattctt caagaaaaac ttcaagaaat cagaaaacat tatctgtcat taaaatctga   3960

agtagcttcc attgatcgga ggagaaagcg tttaaagaag aaagagagag aaagtgctgc   4020

tacatcctca tcctcctctt caccttcatc cagttccata acagctgctg ttatgttaac   4080

tttagctgaa ccgtcaatgt ccagcgcatc acaaaatgga atgcttcaac cactcccaga   4140

agacgtcctt cactcccaaa atgaggcttt tctgaaacgg cgaggaccac caaccgacgg   4200

cgacaaacct gctccctcac ccagcgcctc ccttcgccgc cgcccggcgg ccgactgccg   4260

gaggggaggg ggcgtggcca gagagcggaa gtgcccggaa cccggaagtg cgagctggcg   4320

cgcagctgca gtctgggagt ctttggagta agaatggcct tggaagggat gagcaaacgg   4380

aagagaaaga gaagtgtcca ggagggagag aatcctgacg acggcgttcg cgggagtccg   4440

ccggaagact acaggcttgg acaggtcgcc agtagcttat ttcgcggcga acaccattcc   4500

agaggtggca ccggtcggct ggcgtccctc ttcagttctc tggagcccca gattcaaccc   4560

gtgtacgtgc ctgtgcctaa acaaaccatc aaaaaaacga aacggaatga ggaggaagaa   4620

agtacatccc agattgaaag accactttcg caagaacctg ccaaaaaagt gaaagcgaag   4680

aagaaacaca ctaacgcaga aaaaaagttg gcagacaggg aaagcgctct agcgagtgct   4740

gatttagaag aagaaattca ccagaaacaa gggcagaaaa ggaaaaattc tcaacctggt   4800

gttaaagtag cagatagaaa aatacttgat gacacagaag acacagttgt cagtcaaaga   4860

aagaaaattc aaatcaacca agaagaagag agattaaaga atgagagaac tgtgtttgtt   4920

gggaatttgc ctgttacatg taataagaag aagctgaagt cgttttttaa agagtatgga   4980

caaatagaat ctgtacgatt tcgttctctg attccagcag agggaacgct atccaaaaag   5040

ttggcagcaa taaaacgtaa aattcatcct gatcagaaaa atattaatgc ctatgttgtg   5100

tttaaggagg agagtgctgc cacgcaagca ttgaaaagaa atggggccca gattgcagat   5160

ggatttcgta ttagagttga tctcgcatct gagacctcat ctagagacaa gagatcggtt   5220

tttgtgggga atctccctta taaagttgaa gaatctgcca ttgagaagca ctttctggac   5280

tgtggaagta tcatggccgt gaggattgtg agagacaaaa tgacaggcat cggcaaaggg   5340

tttggctatg tgctctttga gaatacagat tctgttcatc ttgctctgaa attaaataat   5400

tctgaactca tggggagaaa actcagagtc atgcgttctg ttaataaaga aaaatttaaa   5460

caacaaaatt caaatccacg attgaagaat gtcagtaaac ctaagcaggg acttaatttt   5520

acttccaaaa ctgcagaagg acatcctaaa agcttattta ttggagaaaa agctgttctc   5580

cttaaaacga agaagaaagg acagaagaaa agtggacgcc ctaagaaaca gagaaaacag   5640

aaataacaac caggaactgc tttttctttt cctgctgagt actgctaata aaagtgctat   5700

tatctgctga tagcatcgtc tgct                                          5724


<210>  7418
<211>  1296
<212>  PRT
<213>  Homosapiens

<400>  7418

Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Thr Val Gly Thr Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Thr Phe Arg His Asp Ser Ser Thr 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Thr Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro 
        115                 120                 125             


Glu His Phe Gly Thr Pro Val Ile Gly Lys Lys Thr Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Thr Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Thr Ser Asp Thr Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Thr Ile Pro Ala Asn Trp Lys Thr Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile Val Arg Pro Ala Asp Lys 
    530                 535                 540                 


Asn Val Pro Lys Ile Lys His Arg Lys Lys Ile Lys Asn Lys Leu Asp 
545                 550                 555                 560 


Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser Pro Lys Asn Cys Lys Leu 
                565                 570                 575     


Arg Arg Leu Ser Lys Pro Pro Phe Gln Thr Asn Pro Ser Pro Glu Met 
            580                 585                 590         


Val Ser Lys Leu Asp Leu Thr Asp Ala Lys Asn Ser Asp Thr Ala His 
        595                 600                 605             


Ile Lys Ser Ile Glu Ile Thr Ser Ile Leu Asn Gly Leu Gln Ala Ser 
    610                 615                 620                 


Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu Asp Glu Arg Gly Ala Gln 
625                 630                 635                 640 


Asp Met Asp Asn Asn Gly Lys Glu Glu Ser Lys Ile Asp His Leu Thr 
                645                 650                 655     


Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu Glu Gln Asn Ser Ser Ser 
            660                 665                 670         


Leu Leu Glu Glu Asn Lys Val His Ala Asp Leu Val Ile Ser Lys Pro 
        675                 680                 685             


Val Ser Lys Ser Pro Glu Arg Leu Arg Lys Asp Ile Glu Val Leu Ser 
    690                 695                 700                 


Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val Thr Lys Lys Arg Lys Asp 
705                 710                 715                 720 


Val Lys Lys Asp Thr Thr Asp Lys Ser Ser Lys Pro Gln Ile Lys Arg 
                725                 730                 735     


Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu Cys Leu Lys Thr Gly Ser 
            740                 745                 750         


Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn Lys Glu Ser Leu Cys Met 
        755                 760                 765             


Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu Asp Glu Glu Glu Thr Lys 
    770                 775                 780                 


Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn Gly Leu Glu Glu Lys Arg 
785                 790                 795                 800 


Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser Gly Phe Ser Glu Val Ala 
                805                 810                 815     


Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser Asp Glu Arg Leu Gln Asn 
            820                 825                 830         


Ser Arg Ala Lys Asp Arg Lys Asp Val Trp Ser Ser Ile Gln Gly Gln 
        835                 840                 845             


Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe Ser Asp Ser Asp Thr Glu 
    850                 855                 860                 


Ala Ala Ala Ser Pro Pro His Pro Ala Pro Glu Glu Gly Val Ala Glu 
865                 870                 875                 880 


Glu Ser Leu Gln Thr Val Ala Glu Glu Glu Ser Cys Ser Pro Ser Val 
                885                 890                 895     


Glu Leu Glu Lys Pro Pro Pro Val Asn Val Asp Ser Lys Pro Ile Glu 
            900                 905                 910         


Glu Lys Thr Val Glu Val Asn Asp Arg Lys Ala Glu Phe Pro Ser Ser 
        915                 920                 925             


Gly Ser Asn Ser Val Leu Asn Thr Pro Pro Thr Thr Pro Glu Ser Pro 
    930                 935                 940                 


Ser Ser Val Thr Val Thr Glu Gly Ser Arg Gln Gln Ser Ser Val Thr 
945                 950                 955                 960 


Val Ser Glu Pro Leu Ala Pro Asn Gln Glu Glu Val Arg Ser Ile Lys 
                965                 970                 975     


Ser Glu Thr Asp Ser Thr Ile Glu Val Asp Ser Val Ala Gly Glu Leu 
            980                 985                 990         


Gln Asp Leu Gln Ser Glu Gly Asn  Ser Ser Pro Ala Gly  Phe Asp Ala 
        995                 1000                 1005             


Ser Val  Ser Ser Ser Ser Ser  Asn Gln Pro Glu Pro  Glu His Pro 
    1010                 1015                 1020             


Glu Lys  Ala Cys Thr Gly Gln  Lys Arg Val Lys Asp  Ala Gln Gly 
    1025                 1030                 1035             


Gly Gly  Ser Ser Ser Lys Lys  Gln Lys Arg Ser His  Lys Ala Thr 
    1040                 1045                 1050             


Val Val  Asn Asn Lys Lys Lys  Gly Lys Gly Thr Asn  Ser Ser Asp 
    1055                 1060                 1065             


Ser Glu  Glu Leu Ser Ala Gly  Glu Ser Ile Thr Lys  Ser Gln Pro 
    1070                 1075                 1080             


Val Lys  Ser Val Ser Thr Gly  Met Lys Ser His Ser  Thr Lys Ser 
    1085                 1090                 1095             


Pro Ala  Arg Thr Gln Ser Pro  Gly Lys Cys Gly Lys  Asn Gly Asp 
    1100                 1105                 1110             


Lys Asp  Pro Asp Leu Lys Glu  Pro Ser Asn Arg Leu  Pro Lys Val 
    1115                 1120                 1125             


Tyr Lys  Trp Ser Phe Gln Met  Ser Asp Leu Glu Asn  Met Thr Ser 
    1130                 1135                 1140             


Ala Glu  Arg Ile Thr Ile Leu  Gln Glu Lys Leu Gln  Glu Ile Arg 
    1145                 1150                 1155             


Lys His  Tyr Leu Ser Leu Lys  Ser Glu Val Ala Ser  Ile Asp Arg 
    1160                 1165                 1170             


Arg Arg  Lys Arg Leu Lys Lys  Lys Glu Arg Glu Ser  Ala Ala Thr 
    1175                 1180                 1185             


Ser Ser  Ser Ser Ser Ser Pro  Ser Ser Ser Ser Ile  Thr Ala Ala 
    1190                 1195                 1200             


Val Met  Leu Thr Leu Ala Glu  Pro Ser Met Ser Ser  Ala Ser Gln 
    1205                 1210                 1215             


Asn Gly  Met Leu Gln Pro Leu  Pro Glu Asp Val Leu  His Ser Gln 
    1220                 1225                 1230             


Asn Glu  Ala Phe Leu Lys Arg  Arg Gly Pro Pro Thr  Asp Gly Asp 
    1235                 1240                 1245             


Lys Pro  Ala Pro Ser Pro Ser  Ala Ser Leu Arg Arg  Arg Pro Ala 
    1250                 1255                 1260             


Ala Asp  Cys Arg Arg Gly Gly  Gly Val Ala Arg Glu  Arg Lys Cys 
    1265                 1270                 1275             


Pro Glu  Pro Gly Ser Ala Ser  Trp Arg Ala Ala Ala  Val Trp Glu 
    1280                 1285                 1290             


Ser Leu  Glu 
    1295     


<210>  7419
<211>  1107
<212>  DNA
<213>  Homosapiens

<400>  7419
ggcttcaacc actcccagaa gacgtccttc actcccaaaa tgaggctttt ctgaaacggc     60

gaggaccacc aaccgacggc gacaaacctg ctccctcacc cagcgcctcc cttcgccgcc    120

gcccggcggc cgactgccgg aggggagggg gcgtggccag agagcggaag tgcccggaac    180

ccggaagtgc gagctggcgc gcagctgcag tctgggagtc tttggagtaa gaatggcctt    240

ggaagggatg agcaaacgga agagaaagag aagtgtccag gagggagaga atcctgacga    300

cggcgttcgc gggagtccgc cggaagacta caggcttgga caggtcgcca gtagcttatt    360

tcgcggcgaa caccattcca gaggtggcac cggtcggctg gcgtccctct tcagttctct    420

ggagccccag attcaacccg tgtacgtgcc tgtgcctaaa caaaccatca aaaaaacgaa    480

acggaatgag gaggaagaaa gtacatccca gattgaaaga ccactttcgc aagaacctgc    540

caaaaaagtg aaagcgaaga agaaacacac taacgcagaa aaaaagttgg cagacaggga    600

aagcgctcta gcgagtgctg atttagaaga agaaattcac cagaaacaag ggcagaaaag    660

gaaaaattct caacctggtg ttaaagtagc agatagaaaa atacttgatg acacagaaga    720

cacagttgtc agtcaaagaa agaaaattca aatcaaccaa gaagaagaga gattaaagaa    780

tgagagaact gtgtttgttg ggaatttgcc tgttacatgt aataagaaga agctgaagtc    840

gttttttaaa gagtatggac aaatagaatc tgtacgattt cgttctctgg tatgtttcat    900

tcccccgtaa aattacataa tattaaaatt tattgcattt aaatcagatg aacttattgc    960

tgttagtgag atggtgaagc actttaacct tttgaatcaa taggttcaaa tttaacccaa   1020

gaaaagagtt gctcttacta tctactgctg actcttgaac tttttaaata atgtattgag   1080

tttacttaat aaaatgatac tcttgct                                       1107


<210>  7420
<211>  225
<212>  PRT
<213>  Homosapiens

<400>  7420

Met Ala Leu Glu Gly Met Ser Lys Arg Lys Arg Lys Arg Ser Val Gln 
1               5                   10                  15      


Glu Gly Glu Asn Pro Asp Asp Gly Val Arg Gly Ser Pro Pro Glu Asp 
            20                  25                  30          


Tyr Arg Leu Gly Gln Val Ala Ser Ser Leu Phe Arg Gly Glu His His 
        35                  40                  45              


Ser Arg Gly Gly Thr Gly Arg Leu Ala Ser Leu Phe Ser Ser Leu Glu 
    50                  55                  60                  


Pro Gln Ile Gln Pro Val Tyr Val Pro Val Pro Lys Gln Thr Ile Lys 
65                  70                  75                  80  


Lys Thr Lys Arg Asn Glu Glu Glu Glu Ser Thr Ser Gln Ile Glu Arg 
                85                  90                  95      


Pro Leu Ser Gln Glu Pro Ala Lys Lys Val Lys Ala Lys Lys Lys His 
            100                 105                 110         


Thr Asn Ala Glu Lys Lys Leu Ala Asp Arg Glu Ser Ala Leu Ala Ser 
        115                 120                 125             


Ala Asp Leu Glu Glu Glu Ile His Gln Lys Gln Gly Gln Lys Arg Lys 
    130                 135                 140                 


Asn Ser Gln Pro Gly Val Lys Val Ala Asp Arg Lys Ile Leu Asp Asp 
145                 150                 155                 160 


Thr Glu Asp Thr Val Val Ser Gln Arg Lys Lys Ile Gln Ile Asn Gln 
                165                 170                 175     


Glu Glu Glu Arg Leu Lys Asn Glu Arg Thr Val Phe Val Gly Asn Leu 
            180                 185                 190         


Pro Val Thr Cys Asn Lys Lys Lys Leu Lys Ser Phe Phe Lys Glu Tyr 
        195                 200                 205             


Gly Gln Ile Glu Ser Val Arg Phe Arg Ser Leu Val Cys Phe Ile Pro 
    210                 215                 220                 


Pro 
225 


<210>  7421
<211>  741
<212>  DNA
<213>  Homosapiens

<400>  7421
ggaacccgga agtgcgagct ggcgcgcagc tgcagtctgg gagtctttgg agtaagaatg     60

gccttggaag ggatgagcaa acggaagaga aagagaagtg tccaggaggg agagaatcct    120

gacgacggcg ttcgcgggag tccgccggaa gactacaggc ttggacaggt cgccagtagc    180

ttatttcgcg gcgaacacca ttccagaggt ggcaccggtc ggctggcgtc cctcttcagt    240

tctctggagc cccagattca acccgtgtac gtgcctgtgc ctaaacaaac catcaaaaaa    300

acgaaacgga atgaggagga agaaagtaca tcccagattg aaagaccact ttcgcaagaa    360

cctgccaaaa aagtgaaagc gaagaagaaa cacactaacg cagaaaaaaa gttggcagac    420

aggttggtaa aattctctta tttgatgtta aagaaattag atggtaaatt aacattccta    480

tacttggaat attcgtcagt tttatttcat atttctactt tctttcaaaa cttttattat    540

ggaaaatcca gtacatatag aaaagttgaa aaggctaaga aaccccgtgt actcagcatc    600

agcaattact aatatttggc taaccttttt gtatttttac cccactcata taccccctca    660

ttatttgttt ttgtttgttt tgagatggag tcttgatgcc acgcccaggc tgcagtagag    720

tgcagtgatc tcagctcact g                                              741


<210>  7422
<211>  184
<212>  PRT
<213>  Homosapiens

<400>  7422

Met Ala Leu Glu Gly Met Ser Lys Arg Lys Arg Lys Arg Ser Val Gln 
1               5                   10                  15      


Glu Gly Glu Asn Pro Asp Asp Gly Val Arg Gly Ser Pro Pro Glu Asp 
            20                  25                  30          


Tyr Arg Leu Gly Gln Val Ala Ser Ser Leu Phe Arg Gly Glu His His 
        35                  40                  45              


Ser Arg Gly Gly Thr Gly Arg Leu Ala Ser Leu Phe Ser Ser Leu Glu 
    50                  55                  60                  


Pro Gln Ile Gln Pro Val Tyr Val Pro Val Pro Lys Gln Thr Ile Lys 
65                  70                  75                  80  


Lys Thr Lys Arg Asn Glu Glu Glu Glu Ser Thr Ser Gln Ile Glu Arg 
                85                  90                  95      


Pro Leu Ser Gln Glu Pro Ala Lys Lys Val Lys Ala Lys Lys Lys His 
            100                 105                 110         


Thr Asn Ala Glu Lys Lys Leu Ala Asp Arg Leu Val Lys Phe Ser Tyr 
        115                 120                 125             


Leu Met Leu Lys Lys Leu Asp Gly Lys Leu Thr Phe Leu Tyr Leu Glu 
    130                 135                 140                 


Tyr Ser Ser Val Leu Phe His Ile Ser Thr Phe Phe Gln Asn Phe Tyr 
145                 150                 155                 160 


Tyr Gly Lys Ser Ser Thr Tyr Arg Lys Val Glu Lys Ala Lys Lys Pro 
                165                 170                 175     


Arg Val Leu Ser Ile Ser Asn Tyr 
            180                 


<210>  7423
<211>  476
<212>  DNA
<213>  Homosapiens

<400>  7423
ggaacccgga agtgcgagct ggcgcgcagc tgcagtctgg gagtctttgg agtaagaatg     60

gccttggaag ggatgagcaa acggaagaga aagagaagtg tccaggaggg agagaatcct    120

gacgacggcg ttcgcgggag tccgccggaa gactacaggc ttggacaggt cgccagtagc    180

ttatttcgcg gcgaacacca ttccagaggt ggcaccggtc ggctggcgtc cctcttcagt    240

tctctggagc cccagattca acccgtgtac gtgcctgtgc ctaaacaaac catcaaaaaa    300

acgaaacgga atgaggagga agaaagtaca tcccagattg aaagaccact ttcgcaagaa    360

cctgccaaaa aagtgaaagc gaagaagaaa cacactaacg cagaaaaaaa gttggcagac    420

agatggagtc ttgatgccac gcccaggctg cagtagagtg cagtgatctc agctca        476


<210>  7424
<211>  132
<212>  PRT
<213>  Homosapiens

<400>  7424

Met Ala Leu Glu Gly Met Ser Lys Arg Lys Arg Lys Arg Ser Val Gln 
1               5                   10                  15      


Glu Gly Glu Asn Pro Asp Asp Gly Val Arg Gly Ser Pro Pro Glu Asp 
            20                  25                  30          


Tyr Arg Leu Gly Gln Val Ala Ser Ser Leu Phe Arg Gly Glu His His 
        35                  40                  45              


Ser Arg Gly Gly Thr Gly Arg Leu Ala Ser Leu Phe Ser Ser Leu Glu 
    50                  55                  60                  


Pro Gln Ile Gln Pro Val Tyr Val Pro Val Pro Lys Gln Thr Ile Lys 
65                  70                  75                  80  


Lys Thr Lys Arg Asn Glu Glu Glu Glu Ser Thr Ser Gln Ile Glu Arg 
                85                  90                  95      


Pro Leu Ser Gln Glu Pro Ala Lys Lys Val Lys Ala Lys Lys Lys His 
            100                 105                 110         


Thr Asn Ala Glu Lys Lys Leu Ala Asp Arg Trp Ser Leu Asp Ala Thr 
        115                 120                 125             


Pro Arg Leu Gln 
    130         


<210>  7425
<211>  6034
<212>  DNA
<213>  Homosapiens

<400>  7425
agcgatgttt gcccgtcagt cgagtccgga gtgaggagct cggtcgccga agcggaggga     60

gactcttgag cttcatcttg ccgccgccac ggccaccgcc tggacctttg cccggaggga    120

gctgcagagg gtccatcgcc gccgtcctct ggagggcagc gcgattgggg gcccggacct    180

ccagtccggg ggggattttt cgtcgtcccc ctccccccaa ccagggagcc cgagcggccg    240

ccaaacaaag gtaccagtcg ccgccgcggg aggaggagga gccggagcct ctgcctcagc    300

agccgctgga cccgccgccc ttcttcccca tctctccccc gggcctgctg gttttggggg    360

ggagaaggag agaggggact ctggacgtgc cagggtcaga tctcgcctcc gaggaaggtg    420

cagctgaacc tggtgtttta gaggatacct tggtcccaga gtcatcatga aggcccttga    480

tgagcctccc tatttgacag tgggcactga tgtgagtgct aaatacagag gagccttttg    540

tgaagccaag atcaagacag caaaaagact tgtcaaagtc aaggtgacat ttagacatga    600

ttcttcaaca gtggaagttc aggatgacca cataaagggc ccactaaagg taggagctat    660

tgtggaagtg aagaatcttg atggtgcata tcaggaagct gttatcaata aactaacaga    720

tgcgagttgg tacactgtag tttttgatga cggagatgag aagacactga gacgatcttc    780

actgtgcctg aaaggagaga ggcattttgc tgaaagtgaa acattagacc agctcccact    840

caccaaccct gagcattttg gcactccagt cataggaaag aaaacaaata gaggaagaag    900

atctaatcat ataccagagg aagagtcttc atcatcctcc agtgatgaag atgaggatga    960

taggaaacag attgatgagc tactaggcaa agttgtatgt gtagattaca ttagtttgga   1020

taaaaagaaa gcactgtggt ttcctgcatt ggtggtttgt cctgattgta gtgatgagat   1080

tgctgtaaaa aaggacaata ttcttgttcg atctttcaaa gatggaaaat ttacttcagt   1140

tccaagaaaa gatgtccatg aaattactag tgacactgca ccaaagcctg atgctgtttt   1200

aaagcaagcc tttgaacagg cacttgaatt tcacaaaagt agaactattc ctgctaactg   1260

gaagactgaa ttgaaagaag atagctctag cagtgaagca gaggaagaag aggaggagga   1320

agatgatgaa aaagaaaagg aggataatag cagtgaagaa gaagaagaaa tagaaccatt   1380

tccagaagaa agggagaact ttcttcagca attgtacaaa tttatggaag atagaggtac   1440

acctattaac aaacgacctg tacttggata tcgaaatttg aatctcttta agttattcag   1500

acttgtacac aaacttggag gatttgataa tattgaaagt ggagctgttt ggaaacaagt   1560

ctaccaagat cttggaatcc ctgtcttaaa ttcagctgca ggatacaatg ttaaatgtgc   1620

ttataaaaaa tacttatatg gttttgagga gtactgtaga tcagccaaca ttgaatttca   1680

gatggcattg ccagagaaag ttgttaacaa gcaatgtaag gagtgtgaaa atgtaaaaga   1740

aataaaagtt aaggaggaaa atgaaacaga gatcaaagaa ataaagatgg aggaggagag   1800

gaatataata ccaagagaag aaaagcctat tgaggatgaa attgaaagaa aagaaaatat   1860

taagccctct ctgggaagta aaaagaattt attagaatct atacctacac attctgatca   1920

ggaaaaagaa gttaacatta aaaaaccaga agacaatgaa aatctggatg acaaagatga   1980

tgacacaact agggtagatg aatccctcaa cataaaggta gaagctgagg aagaaaaagc   2040

aaaatctgga gatgaaacga ataaagaaga agatgaagat gatgaagaag cagaagagga   2100

ggaggaggag gaagaagaag aagaggatga agatgatgat gacaacaatg aggaagagga   2160

gtttgagtgc tatccaccag gcatgaaagt ccaagtgcgg tatggacgag ggaaaaatca   2220

aaaaatgtat gaagctagta ttaaagattc tgatgtcgaa ggtggagagg tcctttactt   2280

ggtgcattac tgcggatgga atgtgagata cgatgaatgg attaaagcag ataaaatagt   2340

aagacctgct gataaaaatg tgccaaagat aaaacatcgg aagaaaataa agaataaatt   2400

agacaaagaa aaagacaaag atgaaaaata ctctccaaaa aactgtaaac ttcggcgctt   2460

gtccaaacca ccatttcaga caaatccatc tcctgaaatg gtatccaaac tggatctcac   2520

tgatgccaaa aactctgata ctgctcatat taagtccata gaaattactt cgatccttaa   2580

tggacttcaa gcttctgaaa gttctgctga agacagtgag caggaagatg agagaggtgc   2640

tcaagacatg gataataatg gcaaagagga atctaagatt gatcatttga ccaacaacag   2700

aaatgatctt atttcaaagg aggaacagaa cagttcatct ttgctagaag aaaacaaagt   2760

tcatgcagat ttggtaatat ccaaaccagt gtcaaaatct ccagaaagat taaggaaaga   2820

tatagaagta ttatccgaag atactgatta tgaagaagat gaagtcacaa aaaagagaaa   2880

ggatgtcaag aaggacacaa cagataaatc ttcaaaacca caaataaaac gtggtaaaag   2940

aaggtattgc aatacagaag agtgtctaaa aactggatca cctggcaaaa aggaagagaa   3000

ggccaagaac aaagaatcac tttgcatgga aaacagtagc aacagctctt cagatgaaga   3060

tgaagaagaa acaaaagcaa agatgacacc aactaagaaa tacaatggtt tggaggaaaa   3120

aagaaaatct ctacggacaa ctggtttcta ttcaggattt tcagaagtgg cagaaaaaag   3180

gattaaactt ttaaataact ctgatgaaag acttcaaaac agcagggcca aagatcgaaa   3240

agatgtctgg tcaagtattc agggacagtg gcctaaaaaa acgctgaaag agcttttttc   3300

agactctgat actgaggctg cagcttcccc accgcatcct gccccagagg agggggtggc   3360

agaggagtca ctgcagactg tggctgaaga ggagagttgt tcacccagtg tagaactaga   3420

aaaaccacct ccagtcaatg tcgatagtaa acccattgaa gaaaaaacag tagaggtcaa   3480

tgacagaaaa gcagaatttc caagtagtgg cagtaattca gtgctaaata cccctcctac   3540

tacacctgaa tcgccttcat cagtcactgt aacagaaggc agccggcagc agtcttctgt   3600

aacagtatca gaaccactgg ctccaaacca agaagaggtt cgaagtatca agagtgaaac   3660

tgatagcaca attgaggtgg atagtgttgc tggggagctc caagacctcc agtctgaagg   3720

gaatagctcg ccagcaggtt ttgatgccag tgtgagctca agcagtagta atcagccaga   3780

accagaacat cctgaaaaag cctgtacagg tcagaaaaga gtgaaagatg ctcagggagg   3840

aggaagttca tcaaaaaagc agaaaagaag ccataaagca acagtggtaa acaacaaaaa   3900

gaagggaaaa ggcacaaata gtagtgatag tgaagaactt tcagctggtg aaagtataac   3960

taagagtcag ccagtcaaat cagtttccac tggaatgaag tctcatagta ccaaatctcc   4020

cgcaaggacg cagtctccag gaaaatgtgg aaagaatggt gataaggatc ctgatctcaa   4080

ggaacccagt aatcgattac ccaaagttta caaatggagt tttcagatgt cggacctgga   4140

aaatatgaca agtgccgaac gcatcacaat tcttcaagaa aaacttcaag aaatcagaaa   4200

acattatctg tcattaaaat ctgaagtagc ttccattgat cggaggagaa agcgtttaaa   4260

gaagaaagag agagaaagtg ctgctacatc ctcatcctcc tcttcacctt catccagttc   4320

cataacagct gctgttatgt taactttagc tgaaccgtca atgtccagcg catcacaaaa   4380

tggaatgtca gttgagtgca ggtgacagca ggacttgcta aagcactttg cacttaatgg   4440

ctgttgaggg ccactttttt tttatactgc acagtggcac aaaaaaatat cagacaagca   4500

ctattttata tttaaaaatt gtttcttgac aagctgactt ggcacttaag tgcacttttt   4560

tatgaagaaa aagtacaatg aactgctttt cctcaagcaa taattgtttc caacttgtct   4620

gggaattgtg tgtctggtaa ctggaaggcc ttccactgtg gcaaatggag gcttttcact   4680

gcctgtagag acaatacagt aagcatagtt aaggggtggg tcagaacatg ttaagataac   4740

ttactgtata tgtattccct tgtattttgt taaagctgga acatttgata tttttccatt   4800

tatttatgaa aaaatatgaa cctattttca tttgtacaag gtaattgttt tttaaagcaa   4860

gtcaccttag ggtggcttta attgtataag tcaagcacat gtaataaatt caaaacctgc   4920

agttaacagg atattagaca tcaatcctgg taaccaaata ttaaagattc tctttaaaaa   4980

agactgaaca tgtttacagg tttgaattag gctaaaaggt cttgcagtgg cttttcatgg   5040

cccttcaaat tggaatggaa ctactgtact ttgccatttt tctataaatc agtatttttt   5100

tttaattttg atatacattg tgtgaaaaaa gaaaatggct aataaactgt attaaatctt   5160

aaacaatgta taaagattgt acttagccag ttcaaagtgt atatttattc ataatgaatt   5220

ataacagtta tatttttgtg ttttcttgta aatgtttctt ttcccttaaa tacagataat   5280

tcatttgtat tgcttatttt attatgagct acaacaaaag gacttcagga acaagtaatg   5340

tattagtatg gttcaagatt gttgatagga actgtctcaa aaggatggtg gttattttaa   5400

atataaatag ctaatggggg tggtaggcct ataaaattaa atgccttgta taaaatccaa   5460

aatgaatgca aaattgtttt cacttgtatt gactttatgt tgtatgattc caatctctgt   5520

tctgtttggc acttgtattt aattcttcac ctttgtaaga catttgtata ttgtggatgt   5580

gttcattcaa gctatttaat atctggcact gttaatacac agtactttat tgtacagact   5640

gttttactgt tttaattgta gttctgtgta ctttttttgg atggggctgg catgttttct   5700

ttgtttcctg gcaatacgac gtgggaattt caatgcgttt tgttgtagat gctaacgtgt   5760

cagaatcctt tacattcaac ttttctaaga aaagcatttt cagtcttgta gtgtgtgctt   5820

acagtaacta attttgttga aaatggtttc aagttattca aatttgtaca ggactgtaaa   5880

gatttgttga cagcaaaatg ttgaagaaaa aagcttatag aataaaagct ataaagtata   5940

tattaggatc tgcaaacaat gaagaattat gtaatatatt gtacaaatgt aagcaaaggc   6000

tctgaaataa aatgccatag tttgtgaatc cttg                               6034


<210>  7426
<211>  1312
<212>  PRT
<213>  Homosapiens

<400>  7426

Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Thr Val Gly Thr Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Thr Phe Arg His Asp Ser Ser Thr 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Thr Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro 
        115                 120                 125             


Glu His Phe Gly Thr Pro Val Ile Gly Lys Lys Thr Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Thr Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Thr Ser Asp Thr Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Thr Ile Pro Ala Asn Trp Lys Thr Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Asp Glu Thr Asn Lys Glu Glu Asp Glu Asp Asp Glu Glu Ala Glu Glu 
    530                 535                 540                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Asp Asn 
545                 550                 555                 560 


Asn Glu Glu Glu Glu Phe Glu Cys Tyr Pro Pro Gly Met Lys Val Gln 
                565                 570                 575     


Val Arg Tyr Gly Arg Gly Lys Asn Gln Lys Met Tyr Glu Ala Ser Ile 
            580                 585                 590         


Lys Asp Ser Asp Val Glu Gly Gly Glu Val Leu Tyr Leu Val His Tyr 
        595                 600                 605             


Cys Gly Trp Asn Val Arg Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile 
    610                 615                 620                 


Val Arg Pro Ala Asp Lys Asn Val Pro Lys Ile Lys His Arg Lys Lys 
625                 630                 635                 640 


Ile Lys Asn Lys Leu Asp Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser 
                645                 650                 655     


Pro Lys Asn Cys Lys Leu Arg Arg Leu Ser Lys Pro Pro Phe Gln Thr 
            660                 665                 670         


Asn Pro Ser Pro Glu Met Val Ser Lys Leu Asp Leu Thr Asp Ala Lys 
        675                 680                 685             


Asn Ser Asp Thr Ala His Ile Lys Ser Ile Glu Ile Thr Ser Ile Leu 
    690                 695                 700                 


Asn Gly Leu Gln Ala Ser Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu 
705                 710                 715                 720 


Asp Glu Arg Gly Ala Gln Asp Met Asp Asn Asn Gly Lys Glu Glu Ser 
                725                 730                 735     


Lys Ile Asp His Leu Thr Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu 
            740                 745                 750         


Glu Gln Asn Ser Ser Ser Leu Leu Glu Glu Asn Lys Val His Ala Asp 
        755                 760                 765             


Leu Val Ile Ser Lys Pro Val Ser Lys Ser Pro Glu Arg Leu Arg Lys 
    770                 775                 780                 


Asp Ile Glu Val Leu Ser Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val 
785                 790                 795                 800 


Thr Lys Lys Arg Lys Asp Val Lys Lys Asp Thr Thr Asp Lys Ser Ser 
                805                 810                 815     


Lys Pro Gln Ile Lys Arg Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu 
            820                 825                 830         


Cys Leu Lys Thr Gly Ser Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn 
        835                 840                 845             


Lys Glu Ser Leu Cys Met Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu 
    850                 855                 860                 


Asp Glu Glu Glu Thr Lys Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn 
865                 870                 875                 880 


Gly Leu Glu Glu Lys Arg Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser 
                885                 890                 895     


Gly Phe Ser Glu Val Ala Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser 
            900                 905                 910         


Asp Glu Arg Leu Gln Asn Ser Arg Ala Lys Asp Arg Lys Asp Val Trp 
        915                 920                 925             


Ser Ser Ile Gln Gly Gln Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe 
    930                 935                 940                 


Ser Asp Ser Asp Thr Glu Ala Ala Ala Ser Pro Pro His Pro Ala Pro 
945                 950                 955                 960 


Glu Glu Gly Val Ala Glu Glu Ser Leu Gln Thr Val Ala Glu Glu Glu 
                965                 970                 975     


Ser Cys Ser Pro Ser Val Glu Leu Glu Lys Pro Pro Pro Val Asn Val 
            980                 985                 990         


Asp Ser Lys Pro Ile Glu Glu Lys  Thr Val Glu Val Asn  Asp Arg Lys 
        995                 1000                 1005             


Ala Glu  Phe Pro Ser Ser Gly  Ser Asn Ser Val Leu  Asn Thr Pro 
    1010                 1015                 1020             


Pro Thr  Thr Pro Glu Ser Pro  Ser Ser Val Thr Val  Thr Glu Gly 
    1025                 1030                 1035             


Ser Arg  Gln Gln Ser Ser Val  Thr Val Ser Glu Pro  Leu Ala Pro 
    1040                 1045                 1050             


Asn Gln  Glu Glu Val Arg Ser  Ile Lys Ser Glu Thr  Asp Ser Thr 
    1055                 1060                 1065             


Ile Glu  Val Asp Ser Val Ala  Gly Glu Leu Gln Asp  Leu Gln Ser 
    1070                 1075                 1080             


Glu Gly  Asn Ser Ser Pro Ala  Gly Phe Asp Ala Ser  Val Ser Ser 
    1085                 1090                 1095             


Ser Ser  Ser Asn Gln Pro Glu  Pro Glu His Pro Glu  Lys Ala Cys 
    1100                 1105                 1110             


Thr Gly  Gln Lys Arg Val Lys  Asp Ala Gln Gly Gly  Gly Ser Ser 
    1115                 1120                 1125             


Ser Lys  Lys Gln Lys Arg Ser  His Lys Ala Thr Val  Val Asn Asn 
    1130                 1135                 1140             


Lys Lys  Lys Gly Lys Gly Thr  Asn Ser Ser Asp Ser  Glu Glu Leu 
    1145                 1150                 1155             


Ser Ala  Gly Glu Ser Ile Thr  Lys Ser Gln Pro Val  Lys Ser Val 
    1160                 1165                 1170             


Ser Thr  Gly Met Lys Ser His  Ser Thr Lys Ser Pro  Ala Arg Thr 
    1175                 1180                 1185             


Gln Ser  Pro Gly Lys Cys Gly  Lys Asn Gly Asp Lys  Asp Pro Asp 
    1190                 1195                 1200             


Leu Lys  Glu Pro Ser Asn Arg  Leu Pro Lys Val Tyr  Lys Trp Ser 
    1205                 1210                 1215             


Phe Gln  Met Ser Asp Leu Glu  Asn Met Thr Ser Ala  Glu Arg Ile 
    1220                 1225                 1230             


Thr Ile  Leu Gln Glu Lys Leu  Gln Glu Ile Arg Lys  His Tyr Leu 
    1235                 1240                 1245             


Ser Leu  Lys Ser Glu Val Ala  Ser Ile Asp Arg Arg  Arg Lys Arg 
    1250                 1255                 1260             


Leu Lys  Lys Lys Glu Arg Glu  Ser Ala Ala Thr Ser  Ser Ser Ser 
    1265                 1270                 1275             


Ser Ser  Pro Ser Ser Ser Ser  Ile Thr Ala Ala Val  Met Leu Thr 
    1280                 1285                 1290             


Leu Ala  Glu Pro Ser Met Ser  Ser Ala Ser Gln Asn  Gly Met Ser 
    1295                 1300                 1305             


Val Glu  Cys Arg 
    1310         


<210>  7427
<211>  5776
<212>  DNA
<213>  Homosapiens

<400>  7427
agcgatgttt gcccgtcagt cgagtccgga gtgaggagct cggtcgccga agcggaggga     60

gactcttgag cttcatcttg ccgccgccac ggccaccgcc tggacctttg cccggaggga    120

gctgcagagg gtccatcgcc gccgtcctct ggagggcagc gcgattgggg gcccggacct    180

ccagtccggg ggggattttt cgtcgtcccc ctccccccaa ccagggagcc cgagcggccg    240

ccaaacaaag gtaccagtcg ccgccgcggg aggaggagga gccggagcct ctgcctcagc    300

agccgctgga cccgccgccc ttcttcccca tctctccccc gggcctgctg gttttggggg    360

ggagaaggag agaggggact ctggacgtgc cagggtcaga tctcgcctcc gaggaaggtg    420

cagctgaacc tggtgtttta gaggatacct tggtcccaga gtcatcatga aggcccttga    480

tgagcctccc tatttgacag tgggcactga tgtgagtgct aaatacagag gagccttttg    540

tgaagccaag atcaagacag caaaaagact tgtcaaagtc aaggtgacat ttagacatga    600

ttcttcaaca gtggaagttc aggatgacca cataaagggc ccactaaagg taggagctat    660

tgtggaagtg aagaatcttg atggtgcata tcaggaagct gttatcaata aactaacaga    720

tgcgagttgg tacactgtag tttttgatga cggagatgag aagacactga gacgatcttc    780

actgtgcctg aaaggagaga ggcattttgc tgaaagtgaa acattagacc agctcccact    840

caccaaccct gagcattttg gcactccagt cataggaaag aaaacaaata gaggaagaag    900

atctaatcat ataccagagg aagagtcttc atcatcctcc agtgatgaag atgaggatga    960

taggaaacag attgatgagc tactaggcaa agttgtatgt gtagattaca ttagtttgga   1020

taaaaagaaa gcactgtggt ttcctgcatt ggtggtttgt cctgattgta gtgatgagat   1080

tgctgtaaaa aaggacaata ttcttgttcg atctttcaaa gatggaaaat ttacttcagt   1140

tccaagaaaa gatgtccatg aaattactag tgacactgca ccaaagcctg atgctgtttt   1200

aaagcaagcc tttgaacagg cacttgaatt tcacaaaagt agaactattc ctgctaactg   1260

gaagactgaa ttgaaagaag atagctctag cagtgaagca gaggaagaag aggaggagga   1320

agatgatgaa aaagaaaagg aggataatag cagtgaagaa gaagaagaaa tagaaccatt   1380

tccagaagaa agggagaact ttcttcagca attgtacaaa tttatggaag atagaggtac   1440

acctattaac aaacgacctg tacttggata tcgaaatttg aatctcttta agttattcag   1500

acttgtacac aaacttggag gatttgataa tattgaaagt ggagctgttt ggaaacaagt   1560

ctaccaagat cttggaatcc ctgtcttaaa ttcagctgca ggatacaatg ttaaatgtgc   1620

ttataaaaaa tacttatatg gttttgagga gtactgtaga tcagccaaca ttgaatttca   1680

gatggcattg ccagagaaag ttgttaacaa gcaatgtaag gagtgtgaaa atgtaaaaga   1740

aataaaagtt aaggaggaaa atgaaacaga gatcaaagaa ataaagatgg aggaggagag   1800

gaatataata ccaagagaag aaaagcctat tgaggatgaa attgaaagaa aagaaaatat   1860

taagccctct ctgggaagta aaaagaattt attagaatct atacctacac attctgatca   1920

ggaaaaagaa gttaacatta aaaaaccaga agacaatgaa aatctggatg acaaagatga   1980

tgacacaact agggtagatg aatccctcaa cataaaggta gaagctgagg aagaaaaagc   2040

aaaatctgga tacgatgaat ggattaaagc agataaaata gtaagacctg ctgataaaaa   2100

tgtgccaaag ataaaacatc ggaagaaaat aaagaataaa ttagacaaag aaaaagacaa   2160

agatgaaaaa tactctccaa aaaactgtaa acttcggcgc ttgtccaaac caccatttca   2220

gacaaatcca tctcctgaaa tggtatccaa actggatctc actgatgcca aaaactctga   2280

tactgctcat attaagtcca tagaaattac ttcgatcctt aatggacttc aagcttctga   2340

aagttctgct gaagacagtg agcaggaaga tgagagaggt gctcaagaca tggataataa   2400

tggcaaagag gaatctaaga ttgatcattt gaccaacaac agaaatgatc ttatttcaaa   2460

ggaggaacag aacagttcat ctttgctaga agaaaacaaa gttcatgcag atttggtaat   2520

atccaaacca gtgtcaaaat ctccagaaag attaaggaaa gatatagaag tattatccga   2580

agatactgat tatgaagaag atgaagtcac aaaaaagaga aaggatgtca agaaggacac   2640

aacagataaa tcttcaaaac cacaaataaa acgtggtaaa agaaggtatt gcaatacaga   2700

agagtgtcta aaaactggat cacctggcaa aaaggaagag aaggccaaga acaaagaatc   2760

actttgcatg gaaaacagta gcaacagctc ttcagatgaa gatgaagaag aaacaaaagc   2820

aaagatgaca ccaactaaga aatacaatgg tttggaggaa aaaagaaaat ctctacggac   2880

aactggtttc tattcaggat tttcagaagt ggcagaaaaa aggattaaac ttttaaataa   2940

ctctgatgaa agacttcaaa acagcagggc caaagatcga aaagatgtct ggtcaagtat   3000

tcagggacag tggcctaaaa aaacgctgaa agagcttttt tcagactctg atactgaggc   3060

tgcagcttcc ccaccgcatc ctgccccaga ggagggggtg gcagaggagt cactgcagac   3120

tgtggctgaa gaggagagtt gttcacccag tgtagaacta gaaaaaccac ctccagtcaa   3180

tgtcgatagt aaacccattg aagaaaaaac agtagaggtc aatgacagaa aagcagaatt   3240

tccaagtagt ggcagtaatt cagtgctaaa tacccctcct actacacctg aatcgccttc   3300

atcagtcact gtaacagaag gcagccggca gcagtcttct gtaacagtat cagaaccact   3360

ggctccaaac caagaagagg ttcgaagtat caagagtgaa actgatagca caattgaggt   3420

ggatagtgtt gctggggagc tccaagacct ccagtctgaa gggaatagct cgccagcagg   3480

ttttgatgcc agtgtgagct caagcagtag taatcagcca gaaccagaac atcctgaaaa   3540

agcctgtaca ggtcagaaaa gagtgaaaga tgctcaggga ggaggaagtt catcaaaaaa   3600

gcagaaaaga agccataaag caacagtggt aaacaacaaa aagaagggaa aaggcacaaa   3660

tagtagtgat agtgaagaac tttcagctgg tgaaagtata actaagagtc agccagtcaa   3720

atcagtttcc actggaatga agtctcatag taccaaatct cccgcaagga cgcagtctcc   3780

aggaaaatgt ggaaagaatg gtgataagga tcctgatctc aaggaaccca gtaatcgatt   3840

acccaaagtt tacaaatgga gttttcagat gtcggacctg gaaaatatga caagtgccga   3900

acgcatcaca attcttcaag aaaaacttca agaaatcaga aaacattatc tgtcattaaa   3960

atctgaagta gcttccattg atcggaggag aaagcgttta aagaagaaag agagagaaag   4020

tgctgctaca tcctcatcct cctcttcacc ttcatccagt tccataacag ctgctgttat   4080

gttaacttta gctgaaccgt caatgtccag cgcatcacaa aatggaatgt cagttgagtg   4140

caggtgacag caggacttgc taaagcactt tgcacttaat ggctgttgag ggccactttt   4200

tttttatact gcacagtggc acaaaaaaat atcagacaag cactatttta tatttaaaaa   4260

ttgtttcttg acaagctgac ttggcactta agtgcacttt tttatgaaga aaaagtacaa   4320

tgaactgctt ttcctcaagc aataattgtt tccaacttgt ctgggaattg tgtgtctggt   4380

aactggaagg ccttccactg tggcaaatgg aggcttttca ctgcctgtag agacaataca   4440

gtaagcatag ttaaggggtg ggtcagaaca tgttaagata acttactgta tatgtattcc   4500

cttgtatttt gttaaagctg gaacatttga tatttttcca tttatttatg aaaaaatatg   4560

aacctatttt catttgtaca aggtaattgt tttttaaagc aagtcacctt agggtggctt   4620

taattgtata agtcaagcac atgtaataaa ttcaaaacct gcagttaaca ggatattaga   4680

catcaatcct ggtaaccaaa tattaaagat tctctttaaa aaagactgaa catgtttaca   4740

ggtttgaatt aggctaaaag gtcttgcagt ggcttttcat ggcccttcaa attggaatgg   4800

aactactgta ctttgccatt tttctataaa tcagtatttt tttttaattt tgatatacat   4860

tgtgtgaaaa aagaaaatgg ctaataaact gtattaaatc ttaaacaatg tataaagatt   4920

gtacttagcc agttcaaagt gtatatttat tcataatgaa ttataacagt tatatttttg   4980

tgttttcttg taaatgtttc ttttccctta aatacagata attcatttgt attgcttatt   5040

ttattatgag ctacaacaaa aggacttcag gaacaagtaa tgtattagta tggttcaaga   5100

ttgttgatag gaactgtctc aaaaggatgg tggttatttt aaatataaat agctaatggg   5160

ggtggtaggc ctataaaatt aaatgccttg tataaaatcc aaaatgaatg caaaattgtt   5220

ttcacttgta ttgactttat gttgtatgat tccaatctct gttctgtttg gcacttgtat   5280

ttaattcttc acctttgtaa gacatttgta tattgtggat gtgttcattc aagctattta   5340

atatctggca ctgttaatac acagtacttt attgtacaga ctgttttact gttttaattg   5400

tagttctgtg tacttttttt ggatggggct ggcatgtttt ctttgtttcc tggcaatacg   5460

acgtgggaat ttcaatgcgt tttgttgtag atgctaacgt gtcagaatcc tttacattca   5520

acttttctaa gaaaagcatt ttcagtcttg tagtgtgtgc ttacagtaac taattttgtt   5580

gaaaatggtt tcaagttatt caaatttgta caggactgta aagatttgtt gacagcaaaa   5640

tgttgaagaa aaaagcttat agaataaaag ctataaagta tatattagga tctgcaaaca   5700

atgaagaatt atgtaatata ttgtacaaat gtaagcaaag gctctgaaat aaaatgccat   5760

agtttgtgaa tccttg                                                   5776


<210>  7428
<211>  1226
<212>  PRT
<213>  Homosapiens

<400>  7428

Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Thr Val Gly Thr Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Thr Phe Arg His Asp Ser Ser Thr 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Thr Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro 
        115                 120                 125             


Glu His Phe Gly Thr Pro Val Ile Gly Lys Lys Thr Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Thr Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Thr Ser Asp Thr Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Thr Ile Pro Ala Asn Trp Lys Thr Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile Val Arg Pro Ala Asp Lys 
    530                 535                 540                 


Asn Val Pro Lys Ile Lys His Arg Lys Lys Ile Lys Asn Lys Leu Asp 
545                 550                 555                 560 


Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser Pro Lys Asn Cys Lys Leu 
                565                 570                 575     


Arg Arg Leu Ser Lys Pro Pro Phe Gln Thr Asn Pro Ser Pro Glu Met 
            580                 585                 590         


Val Ser Lys Leu Asp Leu Thr Asp Ala Lys Asn Ser Asp Thr Ala His 
        595                 600                 605             


Ile Lys Ser Ile Glu Ile Thr Ser Ile Leu Asn Gly Leu Gln Ala Ser 
    610                 615                 620                 


Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu Asp Glu Arg Gly Ala Gln 
625                 630                 635                 640 


Asp Met Asp Asn Asn Gly Lys Glu Glu Ser Lys Ile Asp His Leu Thr 
                645                 650                 655     


Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu Glu Gln Asn Ser Ser Ser 
            660                 665                 670         


Leu Leu Glu Glu Asn Lys Val His Ala Asp Leu Val Ile Ser Lys Pro 
        675                 680                 685             


Val Ser Lys Ser Pro Glu Arg Leu Arg Lys Asp Ile Glu Val Leu Ser 
    690                 695                 700                 


Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val Thr Lys Lys Arg Lys Asp 
705                 710                 715                 720 


Val Lys Lys Asp Thr Thr Asp Lys Ser Ser Lys Pro Gln Ile Lys Arg 
                725                 730                 735     


Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu Cys Leu Lys Thr Gly Ser 
            740                 745                 750         


Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn Lys Glu Ser Leu Cys Met 
        755                 760                 765             


Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu Asp Glu Glu Glu Thr Lys 
    770                 775                 780                 


Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn Gly Leu Glu Glu Lys Arg 
785                 790                 795                 800 


Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser Gly Phe Ser Glu Val Ala 
                805                 810                 815     


Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser Asp Glu Arg Leu Gln Asn 
            820                 825                 830         


Ser Arg Ala Lys Asp Arg Lys Asp Val Trp Ser Ser Ile Gln Gly Gln 
        835                 840                 845             


Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe Ser Asp Ser Asp Thr Glu 
    850                 855                 860                 


Ala Ala Ala Ser Pro Pro His Pro Ala Pro Glu Glu Gly Val Ala Glu 
865                 870                 875                 880 


Glu Ser Leu Gln Thr Val Ala Glu Glu Glu Ser Cys Ser Pro Ser Val 
                885                 890                 895     


Glu Leu Glu Lys Pro Pro Pro Val Asn Val Asp Ser Lys Pro Ile Glu 
            900                 905                 910         


Glu Lys Thr Val Glu Val Asn Asp Arg Lys Ala Glu Phe Pro Ser Ser 
        915                 920                 925             


Gly Ser Asn Ser Val Leu Asn Thr Pro Pro Thr Thr Pro Glu Ser Pro 
    930                 935                 940                 


Ser Ser Val Thr Val Thr Glu Gly Ser Arg Gln Gln Ser Ser Val Thr 
945                 950                 955                 960 


Val Ser Glu Pro Leu Ala Pro Asn Gln Glu Glu Val Arg Ser Ile Lys 
                965                 970                 975     


Ser Glu Thr Asp Ser Thr Ile Glu Val Asp Ser Val Ala Gly Glu Leu 
            980                 985                 990         


Gln Asp Leu Gln Ser Glu Gly Asn  Ser Ser Pro Ala Gly  Phe Asp Ala 
        995                 1000                 1005             


Ser Val  Ser Ser Ser Ser Ser  Asn Gln Pro Glu Pro  Glu His Pro 
    1010                 1015                 1020             


Glu Lys  Ala Cys Thr Gly Gln  Lys Arg Val Lys Asp  Ala Gln Gly 
    1025                 1030                 1035             


Gly Gly  Ser Ser Ser Lys Lys  Gln Lys Arg Ser His  Lys Ala Thr 
    1040                 1045                 1050             


Val Val  Asn Asn Lys Lys Lys  Gly Lys Gly Thr Asn  Ser Ser Asp 
    1055                 1060                 1065             


Ser Glu  Glu Leu Ser Ala Gly  Glu Ser Ile Thr Lys  Ser Gln Pro 
    1070                 1075                 1080             


Val Lys  Ser Val Ser Thr Gly  Met Lys Ser His Ser  Thr Lys Ser 
    1085                 1090                 1095             


Pro Ala  Arg Thr Gln Ser Pro  Gly Lys Cys Gly Lys  Asn Gly Asp 
    1100                 1105                 1110             


Lys Asp  Pro Asp Leu Lys Glu  Pro Ser Asn Arg Leu  Pro Lys Val 
    1115                 1120                 1125             


Tyr Lys  Trp Ser Phe Gln Met  Ser Asp Leu Glu Asn  Met Thr Ser 
    1130                 1135                 1140             


Ala Glu  Arg Ile Thr Ile Leu  Gln Glu Lys Leu Gln  Glu Ile Arg 
    1145                 1150                 1155             


Lys His  Tyr Leu Ser Leu Lys  Ser Glu Val Ala Ser  Ile Asp Arg 
    1160                 1165                 1170             


Arg Arg  Lys Arg Leu Lys Lys  Lys Glu Arg Glu Ser  Ala Ala Thr 
    1175                 1180                 1185             


Ser Ser  Ser Ser Ser Ser Pro  Ser Ser Ser Ser Ile  Thr Ala Ala 
    1190                 1195                 1200             


Val Met  Leu Thr Leu Ala Glu  Pro Ser Met Ser Ser  Ala Ser Gln 
    1205                 1210                 1215             


Asn Gly  Met Ser Val Glu Cys  Arg 
    1220                 1225     


<210>  7429
<211>  462
<212>  DNA
<213>  Homosapiens

<400>  7429
tgattcatat tcattacaac tctagaaaaa aggctggcaa aaaaactacc ccaggggcaa     60

atctggctta cttgtctttg gaaagaaaaa ttgtactgga acacagccat gcctatttgt    120

ttacatattg cctatgggag ttttcacact taccatggca gagataagta gtttctacag    180

agaccacatg gcccacaaag cctaacatat ttattgtctc tttacagaaa atgtttgcaa    240

cccctgttct acaggaattt tatctctaga atctagagat atgatatgca aatttaaaat    300

atatagatat agcaacacct ttaaaaacat aagtggaggc cgggcacggt ggacgcacct    360

gtagtcctag ctacccggga ggctgaggca ggagaatcgc ttgaaccgga aggcagaggt    420

tgcagtgagc caagatcgcg ccactgcact ccagcctggt ga                       462


<210>  7430
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  7430

Lys His Lys Trp Arg Pro Gly Thr Val Asp Ala Pro Val Val Leu Ala 
1               5                   10                  15      


Thr Arg Glu Ala Glu Ala Gly Glu Ser Leu Glu Pro Glu Gly Arg Gly 
            20                  25                  30          


Cys Ser Glu Pro Arg Ser Arg His Cys Thr Pro Ala Trp 
        35                  40                  45  


<210>  7431
<211>  3808
<212>  DNA
<213>  Homosapiens

<400>  7431
gtttgcccgt cagtcgagtc cggagtgagg agctcggtcg ccgaagcgga gggagactct     60

tgagcttcat cttgccgccg ccacggccac cgcctggacc tttgcccgga gggagctgca    120

gagggtccat cgccgccgtc ctctggaggg cagcgcgatt gggggcccgg acctccagtc    180

cgggggggat ttttcgtcgt ccccctcccc ccaaccaggg agcccgagcg gccgccaaac    240

aaaggtacca gtcgccgccg cgggaggagg aggagccgga gcctctgcct cagcagccgc    300

tggacccgcc gcccttcttc cccatctctc ccccgggcct gctggttttg ggggggagaa    360

ggagagaggg gactctggac gtgccagggt cagatctcgc ctccgaggaa ggtgcagctg    420

aacctggtgt tttagaggat accttggtcc cagagtcatc atgaaggccc ttgatgagcc    480

tccctatttg acagtgggca ctgatgtgag tgctaaatac agaggagcct tttgtgaagc    540

caagatcaag acagcaaaaa gacttgtcaa agtcaaggtg acatttagac atgattcttc    600

aacagtggaa gttcaggatg accacataaa gggcccacta aaggtaggag ctattgtgga    660

agtgaagaat cttgatggtg catatcagga agctgttatc aataaactaa cagatgcgag    720

ttggtacact gtagtttttg atgacggaga tgagaagaca ctgagacgat cttcactgtg    780

cctgaaagga gagaggcatt ttgctgaaag tgaaacatta gaccagctcc cactcaccaa    840

ccctgagcat tttggcactc cagtcatagg aaagaaaaca aatagaggaa gaagatctaa    900

tcatatacca gaggaagagt cttcatcatc ctccagtgat gaagatgagg atgataggaa    960

acagattgat gagctactag gcaaagttgt atgtgtagat tacattagtt tggataaaaa   1020

gaaagcactg tggtttcctg cattggtggt ttgtcctgat tgtagtgatg agattgctgt   1080

aaaaaaggac aatattcttg ttcgatcttt caaagatgga aaatttactt cagttccaag   1140

aaaagatgtc catgaaatta ctagtgacac tgcaccaaag cctgatgctg ttttaaagca   1200

agcctttgaa caggcacttg aatttcacaa aagtagaact attcctgcta actggaagac   1260

tgaattgaaa gaagatagct ctagcagtga agcagaggaa gaagaggagg aggaagatga   1320

tgaaaaagaa aaggaggata atagcagtga agaagaagaa gaaatagaac catttccaga   1380

agaaagggag aactttcttc agcaattgta caaatttatg gaagatagag gtacacctat   1440

taacaaacga cctgtacttg gatatcgaaa tttgaatctc tttaagttat tcagacttgt   1500

acacaaactt ggaggatttg ataatattga aagtggagct gtttggaaac aagtctacca   1560

agatcttgga atccctgtct taaattcagc tgcaggatac aatgttaaat gtgcttataa   1620

aaaatactta tatggttttg aggagtactg tagatcagcc aacattgaat ttcagatggc   1680

attgccagag aaagttgtta acaagcaatg taaggagtgt gaaaatgtaa aagaaataaa   1740

agttaaggag gaaaatgaaa cagagatcaa agaaataaag atggaggagg agaggaatat   1800

aataccaaga gaagaaaagc ctattgagga tgaaattgaa agaaaagaaa atattaagcc   1860

ctctctggga agtaaaaaga atttattaga atctatacct acacattctg atcaggaaaa   1920

agaagttaac attaaaaaac cagaagacaa tgaaaatctg gatgacaaag atgatgacac   1980

aactagggta gatgaatccc tcaacataaa ggtagaagct gaggaagaaa aagcaaaatc   2040

tggatacgat gaatggatta aagcagataa aatagtaaga cctgctgata aaaatgtgcc   2100

aaagataaaa catcggaaga aaataaagaa taaattagac aaagaaaaag acaaagatga   2160

aaaatactct ccaaaaaact gtaaacttcg gcgcttgtcc aaaccaccat ttcagacaaa   2220

tccatctcct gaaatggtat ccaaactgga tctcactgat gccaaaaact ctgatactgc   2280

tcatattaag tccatagaaa ttacttcgat ccttaatgga cttcaagctt ctgaaagttc   2340

tgctgaagac agtgagcagg aagatgagag aggtgctcaa gacatggata ataatggcaa   2400

agaggaatct aagattgatc atttgaccaa caacagaaat gatcttattt caaaggagga   2460

acagaacagt tcatctttgc tagaagaaaa caaagttcat gcagatttgg taatatccaa   2520

accagtgtca aaatctccag aaagattaag gaaagatata gaagtattat ccgaagatac   2580

tgattatgaa gaagatgaag tcacaaaaaa gagaaaggat gtcaagaagg acacaacaga   2640

taaatcttca aaaccacaaa taaaacgtgg taaaagaagg tattgcaata cagaagagtg   2700

tctaaaaact ggatcacctg gcaaaaagga agagaaggcc aagaacaaag aatcactttg   2760

catggaaaac agtagcaaca gctcttcaga tgaagatgaa gaagaaacaa aagcaaagat   2820

gacaccaact aagaaataca atggtttgga ggaaaaaaga aaatctctac ggacaactgg   2880

tttctattca ggattttcag aagtggcaga aaaaaggatt aaacttttaa ataactctga   2940

tgaaagactt caaaacagca gggccaaaga tcgaaaagat gtctggtcaa gtattcaggg   3000

acagtggcct aaaaaaacgc tgaaagagct tttttcagac tctgatactg aggctgcagc   3060

ttccccaccg catcctgccc cagaggaggg ggtggcagag gagtcactgc agactgtggc   3120

tgaagaggag agttgttcac ccagtgtaga actagaaaaa ccacctccag tcaatgtcga   3180

tagtaaaccc attgaagaaa aaacagtaga ggtcaatgac agaaaagcag aatttccaag   3240

tagtggcagt aattcagtgc taaatacccc tcctactaca cctgaatcgc cttcatcagt   3300

cactgtaaca gaaggcagcc ggcagcagtc ttctgtaaca gtatcagaac cactggctcc   3360

aaaccaagaa gaggttcgaa gtatcaagag tgaaactgat agcacaattg aggtggatag   3420

tgttgctggg gagctccaag acctccagtc tgaagggaat agctcgccag caggttttga   3480

tgccagtgtg agctcaagca gtagtaatca gccagaacca gaacatcctg aaaaagcctg   3540

tacaggtcag aaaagagtga aagatgctca gggaggagga agttcatcaa aaaagcagaa   3600

aagaagccat aaagcaacag tggtaaacaa caaaaagaag ggaaaaggca gtaagtgtga   3660

aatctctaat ttttaaaata taaaaataat agctgataat tttaccccca gtaagaaaat   3720

ggtattcagg gtatgggata gtacactatt ttgattttgt ctgtacactc aaaaaaagtc   3780

acacaaattc tgtaaggcta cttgcttt                                      3808


<210>  7432
<211>  1071
<212>  PRT
<213>  Homosapiens

<400>  7432

Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Thr Val Gly Thr Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Thr Phe Arg His Asp Ser Ser Thr 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Thr Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro 
        115                 120                 125             


Glu His Phe Gly Thr Pro Val Ile Gly Lys Lys Thr Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Thr Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Thr Ser Asp Thr Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Thr Ile Pro Ala Asn Trp Lys Thr Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile Val Arg Pro Ala Asp Lys 
    530                 535                 540                 


Asn Val Pro Lys Ile Lys His Arg Lys Lys Ile Lys Asn Lys Leu Asp 
545                 550                 555                 560 


Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser Pro Lys Asn Cys Lys Leu 
                565                 570                 575     


Arg Arg Leu Ser Lys Pro Pro Phe Gln Thr Asn Pro Ser Pro Glu Met 
            580                 585                 590         


Val Ser Lys Leu Asp Leu Thr Asp Ala Lys Asn Ser Asp Thr Ala His 
        595                 600                 605             


Ile Lys Ser Ile Glu Ile Thr Ser Ile Leu Asn Gly Leu Gln Ala Ser 
    610                 615                 620                 


Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu Asp Glu Arg Gly Ala Gln 
625                 630                 635                 640 


Asp Met Asp Asn Asn Gly Lys Glu Glu Ser Lys Ile Asp His Leu Thr 
                645                 650                 655     


Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu Glu Gln Asn Ser Ser Ser 
            660                 665                 670         


Leu Leu Glu Glu Asn Lys Val His Ala Asp Leu Val Ile Ser Lys Pro 
        675                 680                 685             


Val Ser Lys Ser Pro Glu Arg Leu Arg Lys Asp Ile Glu Val Leu Ser 
    690                 695                 700                 


Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val Thr Lys Lys Arg Lys Asp 
705                 710                 715                 720 


Val Lys Lys Asp Thr Thr Asp Lys Ser Ser Lys Pro Gln Ile Lys Arg 
                725                 730                 735     


Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu Cys Leu Lys Thr Gly Ser 
            740                 745                 750         


Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn Lys Glu Ser Leu Cys Met 
        755                 760                 765             


Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu Asp Glu Glu Glu Thr Lys 
    770                 775                 780                 


Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn Gly Leu Glu Glu Lys Arg 
785                 790                 795                 800 


Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser Gly Phe Ser Glu Val Ala 
                805                 810                 815     


Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser Asp Glu Arg Leu Gln Asn 
            820                 825                 830         


Ser Arg Ala Lys Asp Arg Lys Asp Val Trp Ser Ser Ile Gln Gly Gln 
        835                 840                 845             


Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe Ser Asp Ser Asp Thr Glu 
    850                 855                 860                 


Ala Ala Ala Ser Pro Pro His Pro Ala Pro Glu Glu Gly Val Ala Glu 
865                 870                 875                 880 


Glu Ser Leu Gln Thr Val Ala Glu Glu Glu Ser Cys Ser Pro Ser Val 
                885                 890                 895     


Glu Leu Glu Lys Pro Pro Pro Val Asn Val Asp Ser Lys Pro Ile Glu 
            900                 905                 910         


Glu Lys Thr Val Glu Val Asn Asp Arg Lys Ala Glu Phe Pro Ser Ser 
        915                 920                 925             


Gly Ser Asn Ser Val Leu Asn Thr Pro Pro Thr Thr Pro Glu Ser Pro 
    930                 935                 940                 


Ser Ser Val Thr Val Thr Glu Gly Ser Arg Gln Gln Ser Ser Val Thr 
945                 950                 955                 960 


Val Ser Glu Pro Leu Ala Pro Asn Gln Glu Glu Val Arg Ser Ile Lys 
                965                 970                 975     


Ser Glu Thr Asp Ser Thr Ile Glu Val Asp Ser Val Ala Gly Glu Leu 
            980                 985                 990         


Gln Asp Leu Gln Ser Glu Gly Asn  Ser Ser Pro Ala Gly  Phe Asp Ala 
        995                 1000                 1005             


Ser Val  Ser Ser Ser Ser Ser  Asn Gln Pro Glu Pro  Glu His Pro 
    1010                 1015                 1020             


Glu Lys  Ala Cys Thr Gly Gln  Lys Arg Val Lys Asp  Ala Gln Gly 
    1025                 1030                 1035             


Gly Gly  Ser Ser Ser Lys Lys  Gln Lys Arg Ser His  Lys Ala Thr 
    1040                 1045                 1050             


Val Val  Asn Asn Lys Lys Lys  Gly Lys Gly Ser Lys  Cys Glu Ile 
    1055                 1060                 1065             


Ser Asn  Phe 
    1070     


<210>  7433
<211>  1020
<212>  DNA
<213>  Homosapiens

<400>  7433
ttgcaataca gaagagtgtc taaaaactgg atcacctggc aaaaaggaag agaaggccaa     60

gaacaaagaa tcactttgca tggaaaacag tagcaacagc tcttcagatg aagatgaaga    120

agaaacaaaa gcaaagatga caccaactaa gaaatacaat ggtttggagg aaaaaagaaa    180

atctctacgg acaactggtt tctattcagg attttcagaa gtggcagaaa aaaggattaa    240

acttttaaat aactctgatg aaagacttca aaacagcagg gccaaagatc gaaaagatgt    300

ctggtcaagt attcagggac agtggcctaa aaaaacgctg aaagagcttt tttcagactc    360

tgatactgag gctgcagctt ccccaccgca tcctgcccca gaggaggggg tggcagagga    420

gtcactgcag actgtggctg aagaggagag ttgttcaccc agtgtagaac tagaaaaacc    480

acctccagtc aatgtcgata gtaaacccat tgaagaaaaa acagtagagg tcaatgacag    540

aaaagcagaa tttccaagta gtggcagtaa ttcagtgcta aatacccctc ctactacacc    600

tgaatcgcct tcatcagtca ctgtaacaga aggcagccgg cagcagtctt ctgtaacagt    660

atcagaacca ctggctccaa accaagaaga ggttcgaagt atcaagagtg aaactgatag    720

cacaattgag gtggatagtg ttgctgggga gctccaagac ctccagtctg aagggaatag    780

ctcgccagca ggttttgatg ccagtgtgag ctcaagcagt agtaatcagc cagaaccaga    840

acatcctgaa aaagacccct ccacccttaa ccaaatactg tatgtagggg tttggagcaa    900

ccaactgtcc aggcactgct ttcctcagac aaccgtgtca aactgatttt caagcctgac    960

taacttgtcc tgtacaggtc agaaaagagt gaaagatgct cagggaggag gaagttcatc   1020


<210>  7434
<211>  288
<212>  PRT
<213>  Homosapiens

<400>  7434

Met Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu Asp Glu Glu Glu Thr 
1               5                   10                  15      


Lys Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn Gly Leu Glu Glu Lys 
            20                  25                  30          


Arg Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser Gly Phe Ser Glu Val 
        35                  40                  45              


Ala Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser Asp Glu Arg Leu Gln 
    50                  55                  60                  


Asn Ser Arg Ala Lys Asp Arg Lys Asp Val Trp Ser Ser Ile Gln Gly 
65                  70                  75                  80  


Gln Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe Ser Asp Ser Asp Thr 
                85                  90                  95      


Glu Ala Ala Ala Ser Pro Pro His Pro Ala Pro Glu Glu Gly Val Ala 
            100                 105                 110         


Glu Glu Ser Leu Gln Thr Val Ala Glu Glu Glu Ser Cys Ser Pro Ser 
        115                 120                 125             


Val Glu Leu Glu Lys Pro Pro Pro Val Asn Val Asp Ser Lys Pro Ile 
    130                 135                 140                 


Glu Glu Lys Thr Val Glu Val Asn Asp Arg Lys Ala Glu Phe Pro Ser 
145                 150                 155                 160 


Ser Gly Ser Asn Ser Val Leu Asn Thr Pro Pro Thr Thr Pro Glu Ser 
                165                 170                 175     


Pro Ser Ser Val Thr Val Thr Glu Gly Ser Arg Gln Gln Ser Ser Val 
            180                 185                 190         


Thr Val Ser Glu Pro Leu Ala Pro Asn Gln Glu Glu Val Arg Ser Ile 
        195                 200                 205             


Lys Ser Glu Thr Asp Ser Thr Ile Glu Val Asp Ser Val Ala Gly Glu 
    210                 215                 220                 


Leu Gln Asp Leu Gln Ser Glu Gly Asn Ser Ser Pro Ala Gly Phe Asp 
225                 230                 235                 240 


Ala Ser Val Ser Ser Ser Ser Ser Asn Gln Pro Glu Pro Glu His Pro 
                245                 250                 255     


Glu Lys Asp Pro Ser Thr Leu Asn Gln Ile Leu Tyr Val Gly Val Trp 
            260                 265                 270         


Ser Asn Gln Leu Ser Arg His Cys Phe Pro Gln Thr Thr Val Ser Asn 
        275                 280                 285             


<210>  7435
<211>  2315
<212>  DNA
<213>  Homosapiens

<400>  7435
aaaggggggg aacctagagt cggtgggggg gaagcgatgt ttgcccgtca gtcgagtccg     60

gagtgaggag ctcggtcgcc gaagcggagg gagactcttg agcttcatct tgccgccgcc    120

acggccaccg cctggacctt tgcccggagg gagctgcaga gggtccatcg ccgccgtcct    180

ctggagggca gcgcgattgg gggcccggac ctccagtccg ggggggattt ttcgtcgtcc    240

ccctcccccc aaccagggag cccgagcggc cgccaaacaa aggtaccagt cgccgccgcg    300

ggaggaggag gagccggagc ctctgcctca gcagccgctg gacccgccgc ccttcttccc    360

catctctccc ccgggcctgc tggttttggg ggggagaagg agagagggga ctctggacgt    420

gccagggtca gatctcgcct ccgaggaagg tgcagctgaa cctggtgttt tagaggatac    480

cttggtccca gagtcatcat gaaggccctt gatgagcctc cctatttgac agtgggcact    540

gatgtgagtg ctaaatacag aggagccttt tgtgaagcca agatcaagac agcaaaaaga    600

cttgtcaaag tcaaggtgac atttagacat gattcttcaa cagtggaagt tcaggatgac    660

cacataaagg gcccactaaa ggtaggagct attgtggaag tgaagaatct tgatggtgca    720

tatcaggaag ctgttatcaa taaactaaca gatgcgagtt ggtacactgt agtttttgat    780

gacggagatg agaagacact gagacgatct tcactgtgcc tgaaaggaga gaggcatttt    840

gctgaaagtg aaacattaga ccagctccca ctcaccaacc ctgagcattt tggcactcca    900

gtcataggaa agaaaacaaa tagaggaaga agatctaatc atataccaga ggaagagtct    960

tcatcatcct ccagtgatga agatgaggat gataggaaac agattgatga gctactaggc   1020

aaagttgtat gtgtagatta cattagtttg gataaaaaga aagcactgtg gtttcctgca   1080

ttggtggttt gtcctgattg tagtgatgag attgctgtaa aaaaggacaa tattcttgtt   1140

cgatctttca aagatggaaa atttacttca gttccaagaa aagatgtcca tgaaattact   1200

agtgacactg caccaaagcc tgatgctgtt ttaaagcaag cctttgaaca ggcacttgaa   1260

tttcacaaaa gtagaactat tcctgctaac tggaagactg aattgaaaga agatagctct   1320

agcagtgaag cagaggaaga agaggaggag gaagatgatg aaaaagaaaa ggaggataat   1380

agcagtgaag aagaagtaag tgaaaacagt tgataccttt taaaattata aataacagtt   1440

gggtttccct tgtgggttag gatttggcat taagtcatta ctcatataag tatttttagt   1500

atgagaaata tttcataatc ttgtatttga gatcctcata atcagatagt ttacttggtt   1560

actttagata tatgatcttg tgaaatagaa aatattaagc ctgattttcc taataacctc   1620

aaaaacatgt cttagtcttc ctatgctttt tttaatgaga tgattaagaa agtatccacc   1680

aggctgggcg cagtggctca ggcctgtaat cccagcactt tgggaggcca aggcaggcgg   1740

atcacgaggt caggagatcg agaccatcct ggctaacaca gcgaaacccc gtctttacta   1800

aaaatacaaa aaattagccg ggggtggtgg tgggcacctg tagtcccagc tactcggtag   1860

gctgaggcag gagaatggca tgaaaccgag agacggagct tgcagtgagc caagatcgcg   1920

ccactgcact ccagcctggg cgacagagcg agactctgtc tcaaaaaaaa aaaaaaaacg   1980

agaacaaaaa caaaaaaact taccatctag gccaggcacg gtgactcacg accataatcg   2040

tagcactttg ggagggcaag gcaggtggct aacttgaact caggagtttg agaccagact   2100

gggcaacatg gtgaaacccc atctcaacaa aaataaaaat aaaaataatt agcagggcat   2160

gtcagtgcac tccagcccca gtgcactcag tagccccagc tactgaggag gctgtgttgg   2220

gaggacggcc tgagccctgg aggtggaggt tgcaatgagc cgtgaattta ccactgccct   2280

acatcctggg tgacagagtg agaccctgtc ttatt                              2315


<210>  7436
<211>  304
<212>  PRT
<213>  Homosapiens

<400>  7436

Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Thr Val Gly Thr Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Thr Phe Arg His Asp Ser Ser Thr 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Thr Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro 
        115                 120                 125             


Glu His Phe Gly Thr Pro Val Ile Gly Lys Lys Thr Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Thr Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Thr Ser Asp Thr Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Thr Ile Pro Ala Asn Trp Lys Thr Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Val Ser Glu Asn Ser 
    290                 295                 300                 


<210>  7437
<211>  565
<212>  DNA
<213>  Homosapiens

<400>  7437
attacagcat aaagaacatg atgaccagga aagaggctgg tgtgataaat attttaatgc     60

tatttcagaa caagacaaga ctgatgacag ttagtttgag ataaatggga tgttacttta    120

gcaataaaga caaatttaga aattacatgc ctactaaaaa ataagattgt gctggctggg    180

cacggtggct cactttggga ggctgagaca ggcagatcac aaggtcagaa gatcgagacc    240

atcctggcta agacagtgaa accccgtctc tactaaaaat acaaaaaatt agccaggcgt    300

ggtggcacac acctgtagtc ccagttactc gggaggctga gccaggagaa tcacttgaac    360

atggaaggca gaggctgcag tgagccgaga tcataccact gcactccagc ctggtgacag    420

agctaggccc tgtctcttta caaaaaaaga aaaaggaaaa agaaaagaaa aaaagaaaat    480

gtttcaaatg gccaaaggaa acttgcaatt taagagaagg ttgactgttc taaagattct    540

tcagccaaag aaaaagagag agaga                                          565


<210>  7438
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  7438

Ala Glu Ile Ile Pro Leu His Ser Ser Leu Val Thr Glu Leu Gly Pro 
1               5                   10                  15      


Val Ser Leu Gln Lys Lys Lys Lys Glu Lys Glu Lys Lys Lys Arg Lys 
            20                  25                  30          


Cys Phe Lys Trp Pro Lys Glu Thr Cys Asn Leu Arg Glu Gly 
        35                  40                  45      


<210>  7439
<211>  270
<212>  DNA
<213>  Homosapiens

<400>  7439
ccccatctct cccccgggcc tgctggtttt gggggggaga aggagagagg ggactctgga     60

cgtgccaggg tcagatctcg cctccgagga aggtgcagct gaacctggtg ttttagagga    120

taccttggtc ccagagtcat catgaaggta agattgcctg cggaaaacga atctctgggg    180

ttatcgaatt caggaagtag gaggtttcga cgaggtcgtc gtgtggggct tccgagtttt    240

gcagaggaag gtgtgtttgg tgacttggtg                                     270


<210>  7440
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  7440

Met Lys Val Arg Leu Pro Ala Glu Asn Glu Ser Leu Gly Leu Ser Asn 
1               5                   10                  15      


Ser Gly Ser Arg Arg Phe Arg Arg Gly Arg Arg Val Gly Leu Pro Ser 
            20                  25                  30          


Phe Ala Glu Glu Gly Val Phe Gly Asp Leu 
        35                  40          


<210>  7441
<211>  1404
<212>  DNA
<213>  Homosapiens

<400>  7441
agcgagaggc cggccggggg ccaccgaggg gccaggaggg cctgtgggcc gcgggcagga     60

ccggcccgcc acagagcccc tgcccacgtc ccgttccggg ctcagacccg acaagtggga    120

gcgagatcaa catctggccc cgccgcgggg acaacattag ctttgaagtt taaatccaat    180

ggagaagact caagaaacag tccaaagaat tcttctagaa ccctataaat acttacttca    240

gttaccaggt aaacaagtga gaaccaaact ttcacaggca tttaatcatt ggctgaaagt    300

tccagaggac aagctacaga ttattattga agtgacagaa atgttgcata atgccagttt    360

actcatcgat gatattgaag acaactcaaa actccgacgt ggctttccag tggcccacag    420

catctatgga atcccatctg tcatcaattc tgccaattac gtgtatttcc ttggcttgga    480

gaaagtctta acccttgatc acccagatgc agtgaagctt tttacccgcc agcttttgga    540

actccatcag ggacaaggcc tagatattta ctggagggat aattacactt gtcccactga    600

agaagaatat aaagctatgg tgctgcagaa aacaggtgga ctgtttggat tagcagtagg    660

tctcatgcag ttgttctctg attacaaaga agatttaaaa ccgctactta atacacttgg    720

gctctttttc caaattaggg atgattatgc taatctacac tccaaagaat atagtgaaaa    780

caaaagtttt tgtgaagatc tgacagaggg aaagttctca tttcctacta ttcatgctat    840

ttggtcaagg cctgaaagca cccaggtgca gaatatcttg cgccagagaa cagaaaacat    900

agatataaaa aaatactgtg tacattatct tgaggatgta ggttcttttg aatacactcg    960

taataccctt aaagagcttg aagctaaagc ctataaacag attgatgcac gtggtgggaa   1020

ccctgagcta gtagccttag taaaacactt aagtaagatg ttcaaagaag aaaatgaata   1080

atgttaagcc attcttgatt ggacctcata gcttatttta gttaatcttt tttttgtctt   1140

ttagccttac caccttttaa aaaatttgtt attctccaga aacagtaaat aggtgagtag   1200

gggtggtgca agtgaattcg ttttcattta gaagcccctc tgtacagata atcaaaattc   1260

aaagttgaaa gaatcaaaag cagccacagt tatgtaggtc tgatttgaat gtcataattg   1320

cagtgacagg acattgccac caactctatc ctactaccat caatgttgtg tttattccgt   1380

caataaaaaa gacttgcttc cagg                                          1404


<210>  7442
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7442

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7443
<211>  2838
<212>  DNA
<213>  Homosapiens

<400>  7443
agcgagaggc cggccggggg ccaccgaggg gccaggaggg cctgtgggcc gcgggcagga     60

ccggcccgcc acagagcccc tgcccacgtc ccgttccggg ctcagacccg acaagtggga    120

gcgagatcaa catctggccc cgccgcgggg acaacattag ctttgaagtt taaatccaat    180

ggagaagact caagaaacag tccaaagaat tcttctagaa ccctataaat acttacttca    240

gttaccaggt aaacaagtga gaaccaaact ttcacaggca tttaatcatt ggctgaaagt    300

tccagaggac aagctacaga ttattattga agtgacagaa atgttgcata atgccagttt    360

actcatcgat gatattgaag acaactcaaa actccgacgt ggctttccag tggcccacag    420

catctatgga atcccatctg tcatcaattc tgccaattac gtgtatttcc ttggcttgga    480

gaaagtctta acccttgatc acccagatgc agtgaagctt tttacccgcc agcttttgga    540

actccatcag ggacaaggcc tagatattta ctggagggat aattacactt gtcccactga    600

agaagaatat aaagctatgg tgctgcagaa aacaggtgga ctgtttggat tagcagtagg    660

tctcatgcag ttgttctctg attacaaaga agatttaaaa ccgctactta atacacttgg    720

gctctttttc caaattaggg atgattatgc taatctacac tccaaagaat atagtgaaaa    780

caaaagtttt tgtgaagatc tgacagaggg aaagttctca tttcctacta ttcatgctat    840

ttggtcaagg cctgaaagca cccaggtgca gaatatcttg cgccagagaa cagaaaacat    900

agatataaaa aaatactgtg tacattatct tgaggatgta ggttcttttg aatacactcg    960

taataccctt aaagagcttg aagctaaagc ctataaacag attgatgcac gtggtgggaa   1020

ccctgagcta gtagccttag taaaacactt aagtaagatg ttcaaagaag aaaatgaata   1080

atgttaagcc attcttgatt ggacctcata gcttatttta gttaatcttt tttttgtctt   1140

ttagccttac caccttttaa aaaatttgtt attctccaga aacagtaaat aggtgagtag   1200

gggtggtgca agtgaattcg ttttcattta gaagcccctc tgtacagata atcaaaattc   1260

aaagttgaaa gaatcaaaag cagccacagt tatgtaggtc tgatttgaat gtcataattg   1320

cagtgacagg acattgccac caactctatc ctactaccat caatgttgtg tttattccgt   1380

caataaaaaa gacttgcttc caggaatttt tatccataca ctttctaact gtactatctg   1440

ggcagttcca agccagtttc tattagctag ctggaccaaa gaccacaaat ctcttttttt   1500

cctaaacgct gctgtaagga atatctcact tttccccccg gaaacaccct cactgaagtc   1560

ttctatgaaa aggctgataa tgggctgggc gcggtggctc acgcctgtaa tcccagcact   1620

ttgggaggcc gaggcgggca gatcacgagg tcaggagatc gagaccatcc tgacacggtg   1680

aaaccctgtc tctactaaaa atacaaaaaa ttagctgggc gtggtggtgg gcgcctgtag   1740

tcccagctac tcgggaggct gaggcaggag aatggtgtga acccaggagg cggagcttgc   1800

agtgagccga gatagtgcct ctgcactcca gcctgggtga cagagcgaga ctccgtctca   1860

aaaaaaaggg ctgataatga taaacagtga gcactccggt cctttttctt aggttttcct   1920

tttttccttc ctctccaccc cacaagtttt gctttttaac caaggtgtct ctgcttgatg   1980

aaattcacat gctagtctaa atcttttttt ctcccttgta acatttatgt gccccaaact   2040

ggttagtata tgggtacagc attccctttc caattgggaa gcggaaaaag agagtatggg   2100

atattttaga agggagcctt tgaaccttat tatatttccc catcattgat agtgacaatc   2160

ttaaaagggt tgttttctta ccttaagtac aaaagcatgg aaaaatgcgc ttttccttcc   2220

cgcccacatc accaccccga cttgaagaca gtaggtgctt gaatggaaag tgagtaggca   2280

tctttaatcg ccctgattaa aggaaagtgt tagcctgaga gggcctgact gaaaagtaac   2340

caaaggctta atatcaaaca ctaattagct ttttagtgcc ttaaccctga cctggttacc   2400

agttttctgt agtttctaca cccaagccac tgaagtcatc tgtggcccaa gaggtaggac   2460

aaaaaaaaaa aaaaaaaaag ctgatttcaa tatttgattt gttgacatcc caaaatgaaa   2520

gttttatgtt tcccttagaa acatgttttg cttggttcta tagtatgtta cttaggatct   2580

atttaccata tatttgtatg agaaatcctc acccaagcat tcaacctaaa tctttgaaaa   2640

gttgggtgct gtctttagta acttttaaaa tagtttaaat ctcccatttt aatagtgata   2700

aggaaacctg ttaaaatcat ggctattgat gttatagtat ggaaagttga actttatgaa   2760

cccatacttt taaaaagcat ttttaaaaat ctaacactga ctatagaaac aaattaaaat   2820

gtctaccttt aagtataa                                                 2838


<210>  7444
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7444

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7445
<211>  1706
<212>  DNA
<213>  Homosapiens

<400>  7445
cggcggcgat ggaccctctg cagctccctc cgggcaaagg tccaggcggt ggccgtggcg     60

gcggcaagat gaagctcaag agtctccctc cgcttcggcg accgagctcc tcactccgga    120

ctcgactgac gggcaaacat cgcttccccc ccaccgactc taggttcccc ccctttctcc    180

cctcccctag attttttttc cccccctccc ctacctcttt cccggatggc ctcttagacg    240

accttggatt ggttaaagtt ctttagaacc cgcctataca ctgttcctat tggtccctgg    300

atacaaacaa cgacgccatt ttcccaccag ttctatggaa acagaaagtt acgcctcaag    360

gctttctggg aaataaagtc catactctgg ggccaacgcg caaatcctcg tccgcgagaa    420

ctgcaaggcc cgcaatgccc tgcgcctgcg tggaccgatt agctttgaag tttaaatcca    480

atggagaaga ctcaagaaac agtccaaaga attcttctag aaccctataa atacttactt    540

cagttaccag gtaaacaagt gagaaccaaa ctttcacagg catttaatca ttggctgaaa    600

gttccagagg acaagctaca gattattatt gaagtgacag aaatgttgca taatgccagt    660

ttactcatcg atgatattga agacaactca aaactccgac gtggctttcc agtggcccac    720

agcatctatg gaatcccatc tgtcatcaat tctgccaatt acgtgtattt ccttggcttg    780

gagaaagtct taacccttga tcacccagat gcagtgaagc tttttacccg ccagcttttg    840

gaactccatc agggacaagg cctagatatt tactggaggg ataattacac ttgtcccact    900

gaagaagaat ataaagctat ggtgctgcag aaaacaggtg gactgtttgg attagcagta    960

ggtctcatgc agttgttctc tgattacaaa gaagatttaa aaccgctact taatacactt   1020

gggctctttt tccaaattag ggatgattat gctaatctac actccaaaga atatagtgaa   1080

aacaaaagtt tttgtgaaga tctgacagag ggaaagttct catttcctac tattcatgct   1140

atttggtcaa ggcctgaaag cacccaggtg cagaatatct tgcgccagag aacagaaaac   1200

atagatataa aaaaatactg tgtacattat cttgaggatg taggttcttt tgaatacact   1260

cgtaataccc ttaaagagct tgaagctaaa gcctataaac agattgatgc acgtggtggg   1320

aaccctgagc tagtagcctt agtaaaacac ttaagtaaga tgttcaaaga agaaaatgaa   1380

taatgttaag ccattcttga ttggacctca tagcttattt tagttaatct tttttttgtc   1440

ttttagcctt accacctttt aaaaaatttg ttattctcca gaaacagtaa ataggtgagt   1500

aggggtggtg caagtgaatt cgttttcatt tagaagcccc tctgtacaga taatcaaaat   1560

tcaaagttga aagaatcaaa agcagccaca gttatgtagg tctgatttga atgtcataat   1620

tgcagtgaca ggacattgcc accaactcta tcctactacc atcaatgttg tgtttattcc   1680

gtcaataaaa aagacttgct tccagg                                        1706


<210>  7446
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7446

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7447
<211>  3140
<212>  DNA
<213>  Homosapiens

<400>  7447
cggcggcgat ggaccctctg cagctccctc cgggcaaagg tccaggcggt ggccgtggcg     60

gcggcaagat gaagctcaag agtctccctc cgcttcggcg accgagctcc tcactccgga    120

ctcgactgac gggcaaacat cgcttccccc ccaccgactc taggttcccc ccctttctcc    180

cctcccctag attttttttc cccccctccc ctacctcttt cccggatggc ctcttagacg    240

accttggatt ggttaaagtt ctttagaacc cgcctataca ctgttcctat tggtccctgg    300

atacaaacaa cgacgccatt ttcccaccag ttctatggaa acagaaagtt acgcctcaag    360

gctttctggg aaataaagtc catactctgg ggccaacgcg caaatcctcg tccgcgagaa    420

ctgcaaggcc cgcaatgccc tgcgcctgcg tggaccgatt agctttgaag tttaaatcca    480

atggagaaga ctcaagaaac agtccaaaga attcttctag aaccctataa atacttactt    540

cagttaccag gtaaacaagt gagaaccaaa ctttcacagg catttaatca ttggctgaaa    600

gttccagagg acaagctaca gattattatt gaagtgacag aaatgttgca taatgccagt    660

ttactcatcg atgatattga agacaactca aaactccgac gtggctttcc agtggcccac    720

agcatctatg gaatcccatc tgtcatcaat tctgccaatt acgtgtattt ccttggcttg    780

gagaaagtct taacccttga tcacccagat gcagtgaagc tttttacccg ccagcttttg    840

gaactccatc agggacaagg cctagatatt tactggaggg ataattacac ttgtcccact    900

gaagaagaat ataaagctat ggtgctgcag aaaacaggtg gactgtttgg attagcagta    960

ggtctcatgc agttgttctc tgattacaaa gaagatttaa aaccgctact taatacactt   1020

gggctctttt tccaaattag ggatgattat gctaatctac actccaaaga atatagtgaa   1080

aacaaaagtt tttgtgaaga tctgacagag ggaaagttct catttcctac tattcatgct   1140

atttggtcaa ggcctgaaag cacccaggtg cagaatatct tgcgccagag aacagaaaac   1200

atagatataa aaaaatactg tgtacattat cttgaggatg taggttcttt tgaatacact   1260

cgtaataccc ttaaagagct tgaagctaaa gcctataaac agattgatgc acgtggtggg   1320

aaccctgagc tagtagcctt agtaaaacac ttaagtaaga tgttcaaaga agaaaatgaa   1380

taatgttaag ccattcttga ttggacctca tagcttattt tagttaatct tttttttgtc   1440

ttttagcctt accacctttt aaaaaatttg ttattctcca gaaacagtaa ataggtgagt   1500

aggggtggtg caagtgaatt cgttttcatt tagaagcccc tctgtacaga taatcaaaat   1560

tcaaagttga aagaatcaaa agcagccaca gttatgtagg tctgatttga atgtcataat   1620

tgcagtgaca ggacattgcc accaactcta tcctactacc atcaatgttg tgtttattcc   1680

gtcaataaaa aagacttgct tccaggaatt tttatccata cactttctaa ctgtactatc   1740

tgggcagttc caagccagtt tctattagct agctggacca aagaccacaa atctcttttt   1800

ttcctaaacg ctgctgtaag gaatatctca cttttccccc cggaaacacc ctcactgaag   1860

tcttctatga aaaggctgat aatgggctgg gcgcggtggc tcacgcctgt aatcccagca   1920

ctttgggagg ccgaggcggg cagatcacga ggtcaggaga tcgagaccat cctgacacgg   1980

tgaaaccctg tctctactaa aaatacaaaa aattagctgg gcgtggtggt gggcgcctgt   2040

agtcccagct actcgggagg ctgaggcagg agaatggtgt gaacccagga ggcggagctt   2100

gcagtgagcc gagatagtgc ctctgcactc cagcctgggt gacagagcga gactccgtct   2160

caaaaaaaag ggctgataat gataaacagt gagcactccg gtcctttttc ttaggttttc   2220

cttttttcct tcctctccac cccacaagtt ttgcttttta accaaggtgt ctctgcttga   2280

tgaaattcac atgctagtct aaatcttttt ttctcccttg taacatttat gtgccccaaa   2340

ctggttagta tatgggtaca gcattccctt tccaattggg aagcggaaaa agagagtatg   2400

ggatatttta gaagggagcc tttgaacctt attatatttc cccatcattg atagtgacaa   2460

tcttaaaagg gttgttttct taccttaagt acaaaagcat ggaaaaatgc gcttttcctt   2520

cccgcccaca tcaccacccc gacttgaaga cagtaggtgc ttgaatggaa agtgagtagg   2580

catctttaat cgccctgatt aaaggaaagt gttagcctga gagggcctga ctgaaaagta   2640

accaaaggct taatatcaaa cactaattag ctttttagtg ccttaaccct gacctggtta   2700

ccagttttct gtagtttcta cacccaagcc actgaagtca tctgtggccc aagaggtagg   2760

acaaaaaaaa aaaaaaaaaa agctgatttc aatatttgat ttgttgacat cccaaaatga   2820

aagttttatg tttcccttag aaacatgttt tgcttggttc tatagtatgt tacttaggat   2880

ctatttacca tatatttgta tgagaaatcc tcacccaagc attcaaccta aatctttgaa   2940

aagttgggtg ctgtctttag taacttttaa aatagtttaa atctcccatt ttaatagtga   3000

taaggaaacc tgttaaaatc atggctattg atgttatagt atggaaagtt gaactttatg   3060

aacccatact tttaaaaagc atttttaaaa atctaacact gactatagaa acaaattaaa   3120

atgtctacct ttaagtataa                                               3140


<210>  7448
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7448

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7449
<211>  1482
<212>  DNA
<213>  Homosapiens

<400>  7449
gggaggcggc aacgacgcct gcgcagtgtg accgggatgg cgcattttct tgcaccaact     60

aatgcggtgt cgctggcggc tgaggagggc ggagagttct gtggtgaaat agtgggaagg    120

attcatgtag gcatcgggaa gagcctaagt ccacattata aaataggaag ttgatgcggg    180

gtacagttac tcccggaccg gcggcgtgaa agtcgtgata tcatcgttga actattagct    240

ttgaagttta aatccaatgg agaagactca agaaacagtc caaagaattc ttctagaacc    300

ctataaatac ttacttcagt taccaggtaa acaagtgaga accaaacttt cacaggcatt    360

taatcattgg ctgaaagttc cagaggacaa gctacagatt attattgaag tgacagaaat    420

gttgcataat gccagtttac tcatcgatga tattgaagac aactcaaaac tccgacgtgg    480

ctttccagtg gcccacagca tctatggaat cccatctgtc atcaattctg ccaattacgt    540

gtatttcctt ggcttggaga aagtcttaac ccttgatcac ccagatgcag tgaagctttt    600

tacccgccag cttttggaac tccatcaggg acaaggccta gatatttact ggagggataa    660

ttacacttgt cccactgaag aagaatataa agctatggtg ctgcagaaaa caggtggact    720

gtttggatta gcagtaggtc tcatgcagtt gttctctgat tacaaagaag atttaaaacc    780

gctacttaat acacttgggc tctttttcca aattagggat gattatgcta atctacactc    840

caaagaatat agtgaaaaca aaagtttttg tgaagatctg acagagggaa agttctcatt    900

tcctactatt catgctattt ggtcaaggcc tgaaagcacc caggtgcaga atatcttgcg    960

ccagagaaca gaaaacatag atataaaaaa atactgtgta cattatcttg aggatgtagg   1020

ttcttttgaa tacactcgta atacccttaa agagcttgaa gctaaagcct ataaacagat   1080

tgatgcacgt ggtgggaacc ctgagctagt agccttagta aaacacttaa gtaagatgtt   1140

caaagaagaa aatgaataat gttaagccat tcttgattgg acctcatagc ttattttagt   1200

taatcttttt tttgtctttt agccttacca ccttttaaaa aatttgttat tctccagaaa   1260

cagtaaatag gtgagtaggg gtggtgcaag tgaattcgtt ttcatttaga agcccctctg   1320

tacagataat caaaattcaa agttgaaaga atcaaaagca gccacagtta tgtaggtctg   1380

atttgaatgt cataattgca gtgacaggac attgccacca actctatcct actaccatca   1440

atgttgtgtt tattccgtca ataaaaaaga cttgcttcca gg                      1482


<210>  7450
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7450

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7451
<211>  2916
<212>  DNA
<213>  Homosapiens

<400>  7451
gggaggcggc aacgacgcct gcgcagtgtg accgggatgg cgcattttct tgcaccaact     60

aatgcggtgt cgctggcggc tgaggagggc ggagagttct gtggtgaaat agtgggaagg    120

attcatgtag gcatcgggaa gagcctaagt ccacattata aaataggaag ttgatgcggg    180

gtacagttac tcccggaccg gcggcgtgaa agtcgtgata tcatcgttga actattagct    240

ttgaagttta aatccaatgg agaagactca agaaacagtc caaagaattc ttctagaacc    300

ctataaatac ttacttcagt taccaggtaa acaagtgaga accaaacttt cacaggcatt    360

taatcattgg ctgaaagttc cagaggacaa gctacagatt attattgaag tgacagaaat    420

gttgcataat gccagtttac tcatcgatga tattgaagac aactcaaaac tccgacgtgg    480

ctttccagtg gcccacagca tctatggaat cccatctgtc atcaattctg ccaattacgt    540

gtatttcctt ggcttggaga aagtcttaac ccttgatcac ccagatgcag tgaagctttt    600

tacccgccag cttttggaac tccatcaggg acaaggccta gatatttact ggagggataa    660

ttacacttgt cccactgaag aagaatataa agctatggtg ctgcagaaaa caggtggact    720

gtttggatta gcagtaggtc tcatgcagtt gttctctgat tacaaagaag atttaaaacc    780

gctacttaat acacttgggc tctttttcca aattagggat gattatgcta atctacactc    840

caaagaatat agtgaaaaca aaagtttttg tgaagatctg acagagggaa agttctcatt    900

tcctactatt catgctattt ggtcaaggcc tgaaagcacc caggtgcaga atatcttgcg    960

ccagagaaca gaaaacatag atataaaaaa atactgtgta cattatcttg aggatgtagg   1020

ttcttttgaa tacactcgta atacccttaa agagcttgaa gctaaagcct ataaacagat   1080

tgatgcacgt ggtgggaacc ctgagctagt agccttagta aaacacttaa gtaagatgtt   1140

caaagaagaa aatgaataat gttaagccat tcttgattgg acctcatagc ttattttagt   1200

taatcttttt tttgtctttt agccttacca ccttttaaaa aatttgttat tctccagaaa   1260

cagtaaatag gtgagtaggg gtggtgcaag tgaattcgtt ttcatttaga agcccctctg   1320

tacagataat caaaattcaa agttgaaaga atcaaaagca gccacagtta tgtaggtctg   1380

atttgaatgt cataattgca gtgacaggac attgccacca actctatcct actaccatca   1440

atgttgtgtt tattccgtca ataaaaaaga cttgcttcca ggaattttta tccatacact   1500

ttctaactgt actatctggg cagttccaag ccagtttcta ttagctagct ggaccaaaga   1560

ccacaaatct ctttttttcc taaacgctgc tgtaaggaat atctcacttt tccccccgga   1620

aacaccctca ctgaagtctt ctatgaaaag gctgataatg ggctgggcgc ggtggctcac   1680

gcctgtaatc ccagcacttt gggaggccga ggcgggcaga tcacgaggtc aggagatcga   1740

gaccatcctg acacggtgaa accctgtctc tactaaaaat acaaaaaatt agctgggcgt   1800

ggtggtgggc gcctgtagtc ccagctactc gggaggctga ggcaggagaa tggtgtgaac   1860

ccaggaggcg gagcttgcag tgagccgaga tagtgcctct gcactccagc ctgggtgaca   1920

gagcgagact ccgtctcaaa aaaaagggct gataatgata aacagtgagc actccggtcc   1980

tttttcttag gttttccttt tttccttcct ctccacccca caagttttgc tttttaacca   2040

aggtgtctct gcttgatgaa attcacatgc tagtctaaat ctttttttct cccttgtaac   2100

atttatgtgc cccaaactgg ttagtatatg ggtacagcat tccctttcca attgggaagc   2160

ggaaaaagag agtatgggat attttagaag ggagcctttg aaccttatta tatttcccca   2220

tcattgatag tgacaatctt aaaagggttg ttttcttacc ttaagtacaa aagcatggaa   2280

aaatgcgctt ttccttcccg cccacatcac caccccgact tgaagacagt aggtgcttga   2340

atggaaagtg agtaggcatc tttaatcgcc ctgattaaag gaaagtgtta gcctgagagg   2400

gcctgactga aaagtaacca aaggcttaat atcaaacact aattagcttt ttagtgcctt   2460

aaccctgacc tggttaccag ttttctgtag tttctacacc caagccactg aagtcatctg   2520

tggcccaaga ggtaggacaa aaaaaaaaaa aaaaaaagct gatttcaata tttgatttgt   2580

tgacatccca aaatgaaagt tttatgtttc ccttagaaac atgttttgct tggttctata   2640

gtatgttact taggatctat ttaccatata tttgtatgag aaatcctcac ccaagcattc   2700

aacctaaatc tttgaaaagt tgggtgctgt ctttagtaac ttttaaaata gtttaaatct   2760

cccattttaa tagtgataag gaaacctgtt aaaatcatgg ctattgatgt tatagtatgg   2820

aaagttgaac tttatgaacc catactttta aaaagcattt ttaaaaatct aacactgact   2880

atagaaacaa attaaaatgt ctacctttaa gtataa                             2916


<210>  7452
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7452

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7453
<211>  1863
<212>  DNA
<213>  Homosapiens

<400>  7453
agtgtgaccg ggatggcgca ttttcttgca ccaactaatg cggtgtcgct ggcggctgag     60

gagggcggag agttctgtgg tgaaatagtg ggaaggattc atgtaggcat cgggaagagc    120

ctaagtccac attataaaat aggaagttga tgcggggtac agttactccc ggaccggcgg    180

cgtgaaagtc gtgatatcat cgttgaactg tgagcggcag tggcggcggc tggggggaac    240

ccggatggga agaagggcgg gggaggctgg gaggcggggc agaggaaaga aagaaaggag    300

agtgaggacc cggatgctga accggattgt gtatgaattt tccatcccct agctttaagc    360

gaggagggag aggaagggtt ggccaagtgg ggcggaaggg agcatctgag cgaggaggaa    420

gcagaaacct caccgtttct tcccctccgg actctgtgct agcactgtat acgtttgcag    480

ttctctgccc agccgctgtg gaaaatcggc ctcgaagtga ttgaaattcc ctgtttatat    540

caggcggctt ctttcagatc catcgtcttt ctcccggagt atgaatggaa ggattcagta    600

tgcgcttcac atttattagc tttgaagttt aaatccaatg gagaagactc aagaaacagt    660

ccaaagaatt cttctagaac cctataaata cttacttcag ttaccaggta aacaagtgag    720

aaccaaactt tcacaggcat ttaatcattg gctgaaagtt ccagaggaca agctacagat    780

tattattgaa gtgacagaaa tgttgcataa tgccagttta ctcatcgatg atattgaaga    840

caactcaaaa ctccgacgtg gctttccagt ggcccacagc atctatggaa tcccatctgt    900

catcaattct gccaattacg tgtatttcct tggcttggag aaagtcttaa cccttgatca    960

cccagatgca gtgaagcttt ttacccgcca gcttttggaa ctccatcagg gacaaggcct   1020

agatatttac tggagggata attacacttg tcccactgaa gaagaatata aagctatggt   1080

gctgcagaaa acaggtggac tgtttggatt agcagtaggt ctcatgcagt tgttctctga   1140

ttacaaagaa gatttaaaac cgctacttaa tacacttggg ctctttttcc aaattaggga   1200

tgattatgct aatctacact ccaaagaata tagtgaaaac aaaagttttt gtgaagatct   1260

gacagaggga aagttctcat ttcctactat tcatgctatt tggtcaaggc ctgaaagcac   1320

ccaggtgcag aatatcttgc gccagagaac agaaaacata gatataaaaa aatactgtgt   1380

acattatctt gaggatgtag gttcttttga atacactcgt aataccctta aagagcttga   1440

agctaaagcc tataaacaga ttgatgcacg tggtgggaac cctgagctag tagccttagt   1500

aaaacactta agtaagatgt tcaaagaaga aaatgaataa tgttaagcca ttcttgattg   1560

gacctcatag cttattttag ttaatctttt ttttgtcttt tagccttacc accttttaaa   1620

aaatttgtta ttctccagaa acagtaaata ggtgagtagg ggtggtgcaa gtgaattcgt   1680

tttcatttag aagcccctct gtacagataa tcaaaattca aagttgaaag aatcaaaagc   1740

agccacagtt atgtaggtct gatttgaatg tcataattgc agtgacagga cattgccacc   1800

aactctatcc tactaccatc aatgttgtgt ttattccgtc aataaaaaag acttgcttcc   1860

agg                                                                 1863


<210>  7454
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7454

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7455
<211>  3297
<212>  DNA
<213>  Homosapiens

<400>  7455
agtgtgaccg ggatggcgca ttttcttgca ccaactaatg cggtgtcgct ggcggctgag     60

gagggcggag agttctgtgg tgaaatagtg ggaaggattc atgtaggcat cgggaagagc    120

ctaagtccac attataaaat aggaagttga tgcggggtac agttactccc ggaccggcgg    180

cgtgaaagtc gtgatatcat cgttgaactg tgagcggcag tggcggcggc tggggggaac    240

ccggatggga agaagggcgg gggaggctgg gaggcggggc agaggaaaga aagaaaggag    300

agtgaggacc cggatgctga accggattgt gtatgaattt tccatcccct agctttaagc    360

gaggagggag aggaagggtt ggccaagtgg ggcggaaggg agcatctgag cgaggaggaa    420

gcagaaacct caccgtttct tcccctccgg actctgtgct agcactgtat acgtttgcag    480

ttctctgccc agccgctgtg gaaaatcggc ctcgaagtga ttgaaattcc ctgtttatat    540

caggcggctt ctttcagatc catcgtcttt ctcccggagt atgaatggaa ggattcagta    600

tgcgcttcac atttattagc tttgaagttt aaatccaatg gagaagactc aagaaacagt    660

ccaaagaatt cttctagaac cctataaata cttacttcag ttaccaggta aacaagtgag    720

aaccaaactt tcacaggcat ttaatcattg gctgaaagtt ccagaggaca agctacagat    780

tattattgaa gtgacagaaa tgttgcataa tgccagttta ctcatcgatg atattgaaga    840

caactcaaaa ctccgacgtg gctttccagt ggcccacagc atctatggaa tcccatctgt    900

catcaattct gccaattacg tgtatttcct tggcttggag aaagtcttaa cccttgatca    960

cccagatgca gtgaagcttt ttacccgcca gcttttggaa ctccatcagg gacaaggcct   1020

agatatttac tggagggata attacacttg tcccactgaa gaagaatata aagctatggt   1080

gctgcagaaa acaggtggac tgtttggatt agcagtaggt ctcatgcagt tgttctctga   1140

ttacaaagaa gatttaaaac cgctacttaa tacacttggg ctctttttcc aaattaggga   1200

tgattatgct aatctacact ccaaagaata tagtgaaaac aaaagttttt gtgaagatct   1260

gacagaggga aagttctcat ttcctactat tcatgctatt tggtcaaggc ctgaaagcac   1320

ccaggtgcag aatatcttgc gccagagaac agaaaacata gatataaaaa aatactgtgt   1380

acattatctt gaggatgtag gttcttttga atacactcgt aataccctta aagagcttga   1440

agctaaagcc tataaacaga ttgatgcacg tggtgggaac cctgagctag tagccttagt   1500

aaaacactta agtaagatgt tcaaagaaga aaatgaataa tgttaagcca ttcttgattg   1560

gacctcatag cttattttag ttaatctttt ttttgtcttt tagccttacc accttttaaa   1620

aaatttgtta ttctccagaa acagtaaata ggtgagtagg ggtggtgcaa gtgaattcgt   1680

tttcatttag aagcccctct gtacagataa tcaaaattca aagttgaaag aatcaaaagc   1740

agccacagtt atgtaggtct gatttgaatg tcataattgc agtgacagga cattgccacc   1800

aactctatcc tactaccatc aatgttgtgt ttattccgtc aataaaaaag acttgcttcc   1860

aggaattttt atccatacac tttctaactg tactatctgg gcagttccaa gccagtttct   1920

attagctagc tggaccaaag accacaaatc tctttttttc ctaaacgctg ctgtaaggaa   1980

tatctcactt ttccccccgg aaacaccctc actgaagtct tctatgaaaa ggctgataat   2040

gggctgggcg cggtggctca cgcctgtaat cccagcactt tgggaggccg aggcgggcag   2100

atcacgaggt caggagatcg agaccatcct gacacggtga aaccctgtct ctactaaaaa   2160

tacaaaaaat tagctgggcg tggtggtggg cgcctgtagt cccagctact cgggaggctg   2220

aggcaggaga atggtgtgaa cccaggaggc ggagcttgca gtgagccgag atagtgcctc   2280

tgcactccag cctgggtgac agagcgagac tccgtctcaa aaaaaagggc tgataatgat   2340

aaacagtgag cactccggtc ctttttctta ggttttcctt ttttccttcc tctccacccc   2400

acaagttttg ctttttaacc aaggtgtctc tgcttgatga aattcacatg ctagtctaaa   2460

tctttttttc tcccttgtaa catttatgtg ccccaaactg gttagtatat gggtacagca   2520

ttccctttcc aattgggaag cggaaaaaga gagtatggga tattttagaa gggagccttt   2580

gaaccttatt atatttcccc atcattgata gtgacaatct taaaagggtt gttttcttac   2640

cttaagtaca aaagcatgga aaaatgcgct tttccttccc gcccacatca ccaccccgac   2700

ttgaagacag taggtgcttg aatggaaagt gagtaggcat ctttaatcgc cctgattaaa   2760

ggaaagtgtt agcctgagag ggcctgactg aaaagtaacc aaaggcttaa tatcaaacac   2820

taattagctt tttagtgcct taaccctgac ctggttacca gttttctgta gtttctacac   2880

ccaagccact gaagtcatct gtggcccaag aggtaggaca aaaaaaaaaa aaaaaaaagc   2940

tgatttcaat atttgatttg ttgacatccc aaaatgaaag ttttatgttt cccttagaaa   3000

catgttttgc ttggttctat agtatgttac ttaggatcta tttaccatat atttgtatga   3060

gaaatcctca cccaagcatt caacctaaat ctttgaaaag ttgggtgctg tctttagtaa   3120

cttttaaaat agtttaaatc tcccatttta atagtgataa ggaaacctgt taaaatcatg   3180

gctattgatg ttatagtatg gaaagttgaa ctttatgaac ccatactttt aaaaagcatt   3240

tttaaaaatc taacactgac tatagaaaca aattaaaatg tctaccttta agtataa      3297


<210>  7456
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7456

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7457
<211>  1362
<212>  DNA
<213>  Homosapiens

<400>  7457
gtgaccggga tggcgcattt tcttgcacca actaatgcgg tgtcgctggc ggctgaggag     60

ggcggagagt tctgtggtga aatagtggga aggattcatg taggcatcgg gaagagccta    120

agtccacatt ataaaatagg aagttgatgc ggggtacagt tactcccgga ccggcggcgt    180

gaaagtcgtg atatcatcgt tgaactgtaa acaagtgaga accaaacttt cacaggcatt    240

taatcattgg ctgaaagttc cagaggacaa gctacagatt attattgaag tgacagaaat    300

gttgcataat gccagtttac tcatcgatga tattgaagac aactcaaaac tccgacgtgg    360

ctttccagtg gcccacagca tctatggaat cccatctgtc atcaattctg ccaattacgt    420

gtatttcctt ggcttggaga aagtcttaac ccttgatcac ccagatgcag tgaagctttt    480

tacccgccag cttttggaac tccatcaggg acaaggccta gatatttact ggagggataa    540

ttacacttgt cccactgaag aagaatataa agctatggtg ctgcagaaaa caggtggact    600

gtttggatta gcagtaggtc tcatgcagtt gttctctgat tacaaagaag atttaaaacc    660

gctacttaat acacttgggc tctttttcca aattagggat gattatgcta atctacactc    720

caaagaatat agtgaaaaca aaagtttttg tgaagatctg acagagggaa agttctcatt    780

tcctactatt catgctattt ggtcaaggcc tgaaagcacc caggtgcaga atatcttgcg    840

ccagagaaca gaaaacatag atataaaaaa atactgtgta cattatcttg aggatgtagg    900

ttcttttgaa tacactcgta atacccttaa agagcttgaa gctaaagcct ataaacagat    960

tgatgcacgt ggtgggaacc ctgagctagt agccttagta aaacacttaa gtaagatgtt   1020

caaagaagaa aatgaataat gttaagccat tcttgattgg acctcatagc ttattttagt   1080

taatcttttt tttgtctttt agccttacca ccttttaaaa aatttgttat tctccagaaa   1140

cagtaaatag gtgagtaggg gtggtgcaag tgaattcgtt ttcatttaga agcccctctg   1200

tacagataat caaaattcaa agttgaaaga atcaaaagca gccacagtta tgtaggtctg   1260

atttgaatgt cataattgca gtgacaggac attgccacca actctatcct actaccatca   1320

atgttgtgtt tattccgtca ataaaaaaga cttgcttcca gg                      1362


<210>  7458
<211>  246
<212>  PRT
<213>  Homosapiens

<400>  7458

Met Leu His Asn Ala Ser Leu Leu Ile Asp Asp Ile Glu Asp Asn Ser 
1               5                   10                  15      


Lys Leu Arg Arg Gly Phe Pro Val Ala His Ser Ile Tyr Gly Ile Pro 
            20                  25                  30          


Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr Phe Leu Gly Leu Glu Lys 
        35                  40                  45              


Val Leu Thr Leu Asp His Pro Asp Ala Val Lys Leu Phe Thr Arg Gln 
    50                  55                  60                  


Leu Leu Glu Leu His Gln Gly Gln Gly Leu Asp Ile Tyr Trp Arg Asp 
65                  70                  75                  80  


Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr Lys Ala Met Val Leu Gln 
                85                  90                  95      


Lys Thr Gly Gly Leu Phe Gly Leu Ala Val Gly Leu Met Gln Leu Phe 
            100                 105                 110         


Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu Leu Asn Thr Leu Gly Leu 
        115                 120                 125             


Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn Leu His Ser Lys Glu Tyr 
    130                 135                 140                 


Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu Thr Glu Gly Lys Phe Ser 
145                 150                 155                 160 


Phe Pro Thr Ile His Ala Ile Trp Ser Arg Pro Glu Ser Thr Gln Val 
                165                 170                 175     


Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn Ile Asp Ile Lys Lys Tyr 
            180                 185                 190         


Cys Val His Tyr Leu Glu Asp Val Gly Ser Phe Glu Tyr Thr Arg Asn 
        195                 200                 205             


Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr Lys Gln Ile Asp Ala Arg 
    210                 215                 220                 


Gly Gly Asn Pro Glu Leu Val Ala Leu Val Lys His Leu Ser Lys Met 
225                 230                 235                 240 


Phe Lys Glu Glu Asn Glu 
                245     


<210>  7459
<211>  2796
<212>  DNA
<213>  Homosapiens

<400>  7459
gtgaccggga tggcgcattt tcttgcacca actaatgcgg tgtcgctggc ggctgaggag     60

ggcggagagt tctgtggtga aatagtggga aggattcatg taggcatcgg gaagagccta    120

agtccacatt ataaaatagg aagttgatgc ggggtacagt tactcccgga ccggcggcgt    180

gaaagtcgtg atatcatcgt tgaactgtaa acaagtgaga accaaacttt cacaggcatt    240

taatcattgg ctgaaagttc cagaggacaa gctacagatt attattgaag tgacagaaat    300

gttgcataat gccagtttac tcatcgatga tattgaagac aactcaaaac tccgacgtgg    360

ctttccagtg gcccacagca tctatggaat cccatctgtc atcaattctg ccaattacgt    420

gtatttcctt ggcttggaga aagtcttaac ccttgatcac ccagatgcag tgaagctttt    480

tacccgccag cttttggaac tccatcaggg acaaggccta gatatttact ggagggataa    540

ttacacttgt cccactgaag aagaatataa agctatggtg ctgcagaaaa caggtggact    600

gtttggatta gcagtaggtc tcatgcagtt gttctctgat tacaaagaag atttaaaacc    660

gctacttaat acacttgggc tctttttcca aattagggat gattatgcta atctacactc    720

caaagaatat agtgaaaaca aaagtttttg tgaagatctg acagagggaa agttctcatt    780

tcctactatt catgctattt ggtcaaggcc tgaaagcacc caggtgcaga atatcttgcg    840

ccagagaaca gaaaacatag atataaaaaa atactgtgta cattatcttg aggatgtagg    900

ttcttttgaa tacactcgta atacccttaa agagcttgaa gctaaagcct ataaacagat    960

tgatgcacgt ggtgggaacc ctgagctagt agccttagta aaacacttaa gtaagatgtt   1020

caaagaagaa aatgaataat gttaagccat tcttgattgg acctcatagc ttattttagt   1080

taatcttttt tttgtctttt agccttacca ccttttaaaa aatttgttat tctccagaaa   1140

cagtaaatag gtgagtaggg gtggtgcaag tgaattcgtt ttcatttaga agcccctctg   1200

tacagataat caaaattcaa agttgaaaga atcaaaagca gccacagtta tgtaggtctg   1260

atttgaatgt cataattgca gtgacaggac attgccacca actctatcct actaccatca   1320

atgttgtgtt tattccgtca ataaaaaaga cttgcttcca ggaattttta tccatacact   1380

ttctaactgt actatctggg cagttccaag ccagtttcta ttagctagct ggaccaaaga   1440

ccacaaatct ctttttttcc taaacgctgc tgtaaggaat atctcacttt tccccccgga   1500

aacaccctca ctgaagtctt ctatgaaaag gctgataatg ggctgggcgc ggtggctcac   1560

gcctgtaatc ccagcacttt gggaggccga ggcgggcaga tcacgaggtc aggagatcga   1620

gaccatcctg acacggtgaa accctgtctc tactaaaaat acaaaaaatt agctgggcgt   1680

ggtggtgggc gcctgtagtc ccagctactc gggaggctga ggcaggagaa tggtgtgaac   1740

ccaggaggcg gagcttgcag tgagccgaga tagtgcctct gcactccagc ctgggtgaca   1800

gagcgagact ccgtctcaaa aaaaagggct gataatgata aacagtgagc actccggtcc   1860

tttttcttag gttttccttt tttccttcct ctccacccca caagttttgc tttttaacca   1920

aggtgtctct gcttgatgaa attcacatgc tagtctaaat ctttttttct cccttgtaac   1980

atttatgtgc cccaaactgg ttagtatatg ggtacagcat tccctttcca attgggaagc   2040

ggaaaaagag agtatgggat attttagaag ggagcctttg aaccttatta tatttcccca   2100

tcattgatag tgacaatctt aaaagggttg ttttcttacc ttaagtacaa aagcatggaa   2160

aaatgcgctt ttccttcccg cccacatcac caccccgact tgaagacagt aggtgcttga   2220

atggaaagtg agtaggcatc tttaatcgcc ctgattaaag gaaagtgtta gcctgagagg   2280

gcctgactga aaagtaacca aaggcttaat atcaaacact aattagcttt ttagtgcctt   2340

aaccctgacc tggttaccag ttttctgtag tttctacacc caagccactg aagtcatctg   2400

tggcccaaga ggtaggacaa aaaaaaaaaa aaaaaaagct gatttcaata tttgatttgt   2460

tgacatccca aaatgaaagt tttatgtttc ccttagaaac atgttttgct tggttctata   2520

gtatgttact taggatctat ttaccatata tttgtatgag aaatcctcac ccaagcattc   2580

aacctaaatc tttgaaaagt tgggtgctgt ctttagtaac ttttaaaata gtttaaatct   2640

cccattttaa tagtgataag gaaacctgtt aaaatcatgg ctattgatgt tatagtatgg   2700

aaagttgaac tttatgaacc catactttta aaaagcattt ttaaaaatct aacactgact   2760

atagaaacaa attaaaatgt ctacctttaa gtataa                             2796


<210>  7460
<211>  246
<212>  PRT
<213>  Homosapiens

<400>  7460

Met Leu His Asn Ala Ser Leu Leu Ile Asp Asp Ile Glu Asp Asn Ser 
1               5                   10                  15      


Lys Leu Arg Arg Gly Phe Pro Val Ala His Ser Ile Tyr Gly Ile Pro 
            20                  25                  30          


Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr Phe Leu Gly Leu Glu Lys 
        35                  40                  45              


Val Leu Thr Leu Asp His Pro Asp Ala Val Lys Leu Phe Thr Arg Gln 
    50                  55                  60                  


Leu Leu Glu Leu His Gln Gly Gln Gly Leu Asp Ile Tyr Trp Arg Asp 
65                  70                  75                  80  


Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr Lys Ala Met Val Leu Gln 
                85                  90                  95      


Lys Thr Gly Gly Leu Phe Gly Leu Ala Val Gly Leu Met Gln Leu Phe 
            100                 105                 110         


Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu Leu Asn Thr Leu Gly Leu 
        115                 120                 125             


Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn Leu His Ser Lys Glu Tyr 
    130                 135                 140                 


Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu Thr Glu Gly Lys Phe Ser 
145                 150                 155                 160 


Phe Pro Thr Ile His Ala Ile Trp Ser Arg Pro Glu Ser Thr Gln Val 
                165                 170                 175     


Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn Ile Asp Ile Lys Lys Tyr 
            180                 185                 190         


Cys Val His Tyr Leu Glu Asp Val Gly Ser Phe Glu Tyr Thr Arg Asn 
        195                 200                 205             


Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr Lys Gln Ile Asp Ala Arg 
    210                 215                 220                 


Gly Gly Asn Pro Glu Leu Val Ala Leu Val Lys His Leu Ser Lys Met 
225                 230                 235                 240 


Phe Lys Glu Glu Asn Glu 
                245     


<210>  7461
<211>  1327
<212>  DNA
<213>  Homosapiens

<400>  7461
cttgcaccaa ctaatgcggt gtcgctggcg gctgaggagg gcggagagtt ctgtggtgaa     60

atagtgggaa ggattcatat tagctttgaa gtttaaatcc aatggagaag actcaagaaa    120

cagtccaaag aattcttcta gaaccctata aatacttact tcagttacca ggtaaacaag    180

tgagaaccaa actttcacag gcatttaatc attggctgaa agttccagag gacaagctac    240

agattattat tgaagtgaca gaaatgttgc ataatgccag tttactcatc gatgatattg    300

aagacaactc aaaactccga cgtggctttc cagtggccca cagcatctat ggaatcccat    360

ctgtcatcaa ttctgccaat tacgtgtatt tccttggctt ggagaaagtc ttaacccttg    420

atcacccaga tgcagtgaag ctttttaccc gccagctttt ggaactccat cagggacaag    480

gcctagatat ttactggagg gataattaca cttgtcccac tgaagaagaa tataaagcta    540

tggtgctgca gaaaacaggt ggactgtttg gattagcagt aggtctcatg cagttgttct    600

ctgattacaa agaagattta aaaccgctac ttaatacact tgggctcttt ttccaaatta    660

gggatgatta tgctaatcta cactccaaag aatatagtga aaacaaaagt ttttgtgaag    720

atctgacaga gggaaagttc tcatttccta ctattcatgc tatttggtca aggcctgaaa    780

gcacccaggt gcagaatatc ttgcgccaga gaacagaaaa catagatata aaaaaatact    840

gtgtacatta tcttgaggat gtaggttctt ttgaatacac tcgtaatacc cttaaagagc    900

ttgaagctaa agcctataaa cagattgatg cacgtggtgg gaaccctgag ctagtagcct    960

tagtaaaaca cttaagtaag atgttcaaag aagaaaatga ataatgttaa gccattcttg   1020

attggacctc atagcttatt ttagttaatc ttttttttgt cttttagcct taccaccttt   1080

taaaaaattt gttattctcc agaaacagta aataggtgag taggggtggt gcaagtgaat   1140

tcgttttcat ttagaagccc ctctgtacag ataatcaaaa ttcaaagttg aaagaatcaa   1200

aagcagccac agttatgtag gtctgatttg aatgtcataa ttgcagtgac aggacattgc   1260

caccaactct atcctactac catcaatgtt gtgtttattc cgtcaataaa aaagacttgc   1320

ttccagg                                                             1327


<210>  7462
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7462

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7463
<211>  2761
<212>  DNA
<213>  Homosapiens

<400>  7463
cttgcaccaa ctaatgcggt gtcgctggcg gctgaggagg gcggagagtt ctgtggtgaa     60

atagtgggaa ggattcatat tagctttgaa gtttaaatcc aatggagaag actcaagaaa    120

cagtccaaag aattcttcta gaaccctata aatacttact tcagttacca ggtaaacaag    180

tgagaaccaa actttcacag gcatttaatc attggctgaa agttccagag gacaagctac    240

agattattat tgaagtgaca gaaatgttgc ataatgccag tttactcatc gatgatattg    300

aagacaactc aaaactccga cgtggctttc cagtggccca cagcatctat ggaatcccat    360

ctgtcatcaa ttctgccaat tacgtgtatt tccttggctt ggagaaagtc ttaacccttg    420

atcacccaga tgcagtgaag ctttttaccc gccagctttt ggaactccat cagggacaag    480

gcctagatat ttactggagg gataattaca cttgtcccac tgaagaagaa tataaagcta    540

tggtgctgca gaaaacaggt ggactgtttg gattagcagt aggtctcatg cagttgttct    600

ctgattacaa agaagattta aaaccgctac ttaatacact tgggctcttt ttccaaatta    660

gggatgatta tgctaatcta cactccaaag aatatagtga aaacaaaagt ttttgtgaag    720

atctgacaga gggaaagttc tcatttccta ctattcatgc tatttggtca aggcctgaaa    780

gcacccaggt gcagaatatc ttgcgccaga gaacagaaaa catagatata aaaaaatact    840

gtgtacatta tcttgaggat gtaggttctt ttgaatacac tcgtaatacc cttaaagagc    900

ttgaagctaa agcctataaa cagattgatg cacgtggtgg gaaccctgag ctagtagcct    960

tagtaaaaca cttaagtaag atgttcaaag aagaaaatga ataatgttaa gccattcttg   1020

attggacctc atagcttatt ttagttaatc ttttttttgt cttttagcct taccaccttt   1080

taaaaaattt gttattctcc agaaacagta aataggtgag taggggtggt gcaagtgaat   1140

tcgttttcat ttagaagccc ctctgtacag ataatcaaaa ttcaaagttg aaagaatcaa   1200

aagcagccac agttatgtag gtctgatttg aatgtcataa ttgcagtgac aggacattgc   1260

caccaactct atcctactac catcaatgtt gtgtttattc cgtcaataaa aaagacttgc   1320

ttccaggaat ttttatccat acactttcta actgtactat ctgggcagtt ccaagccagt   1380

ttctattagc tagctggacc aaagaccaca aatctctttt tttcctaaac gctgctgtaa   1440

ggaatatctc acttttcccc ccggaaacac cctcactgaa gtcttctatg aaaaggctga   1500

taatgggctg ggcgcggtgg ctcacgcctg taatcccagc actttgggag gccgaggcgg   1560

gcagatcacg aggtcaggag atcgagacca tcctgacacg gtgaaaccct gtctctacta   1620

aaaatacaaa aaattagctg ggcgtggtgg tgggcgcctg tagtcccagc tactcgggag   1680

gctgaggcag gagaatggtg tgaacccagg aggcggagct tgcagtgagc cgagatagtg   1740

cctctgcact ccagcctggg tgacagagcg agactccgtc tcaaaaaaaa gggctgataa   1800

tgataaacag tgagcactcc ggtccttttt cttaggtttt ccttttttcc ttcctctcca   1860

ccccacaagt tttgcttttt aaccaaggtg tctctgcttg atgaaattca catgctagtc   1920

taaatctttt tttctccctt gtaacattta tgtgccccaa actggttagt atatgggtac   1980

agcattccct ttccaattgg gaagcggaaa aagagagtat gggatatttt agaagggagc   2040

ctttgaacct tattatattt ccccatcatt gatagtgaca atcttaaaag ggttgttttc   2100

ttaccttaag tacaaaagca tggaaaaatg cgcttttcct tcccgcccac atcaccaccc   2160

cgacttgaag acagtaggtg cttgaatgga aagtgagtag gcatctttaa tcgccctgat   2220

taaaggaaag tgttagcctg agagggcctg actgaaaagt aaccaaaggc ttaatatcaa   2280

acactaatta gctttttagt gccttaaccc tgacctggtt accagttttc tgtagtttct   2340

acacccaagc cactgaagtc atctgtggcc caagaggtag gacaaaaaaa aaaaaaaaaa   2400

aagctgattt caatatttga tttgttgaca tcccaaaatg aaagttttat gtttccctta   2460

gaaacatgtt ttgcttggtt ctatagtatg ttacttagga tctatttacc atatatttgt   2520

atgagaaatc ctcacccaag cattcaacct aaatctttga aaagttgggt gctgtcttta   2580

gtaactttta aaatagttta aatctcccat tttaatagtg ataaggaaac ctgttaaaat   2640

catggctatt gatgttatag tatggaaagt tgaactttat gaacccatac ttttaaaaag   2700

catttttaaa aatctaacac tgactataga aacaaattaa aatgtctacc tttaagtata   2760

a                                                                   2761


<210>  7464
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7464

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7465
<211>  2368
<212>  DNA
<213>  Homosapiens

<400>  7465
gagagtgagg acccggatgc tgaaccggat tgtgtatgaa ttttccatcc cctagcttta     60

agcgaggagg gagaggaagg gttggccaag tggggcggaa gggagcatct gagcgaggag    120

gaagcagaaa cctcaccgtt tcttcccctc cggactctgt gctagcactg tatacgtttg    180

cagttctctg cccagccgct gtggaaaatc ggcctcgaag tgattgaaat tccctgttta    240

tatcaggcgg cttctttcag atccatcgtc tttctcccgg agtatgaatg gaaggattca    300

gtatgcgctt cacatttgta tgtctctggc cattctcaaa ccaggccctt ccctttgaaa    360

agtcttttgc atgggatgtt cacttcttag acgcaaggtt gtgtgccctg gtttcatcgt    420

ctaacgcgtt agaaggcgct ttcatttctt catgggtgtt gagcgccgac cactggggtg    480

gcctctgcct tcgtagacct gcgcctggtg agacggacag atgctgaaca aaacgatgtg    540

aaattaccgc agtggcagtg ccccagagga gagttccacg gtgataggag aatgagggaa    600

tttggcttct ttagggaggg aaaggaaggg tttctgagca agtgaggatc gagctgagag    660

ctgaagggct agcaggagtt aactaaggaa agagaaaagg aaaagacatt ccagacaaaa    720

agactaactt gtcagaaagc cctgtggcgg aagggagctt ttccaatatg aagaactgag    780

cctggagaga tgggatgagg gggagtgtcg aaccttttag gctttgtaaa ggagttttgg    840

ttttctccta atagcaatgg gatatcttcc aaggaatctc aatcaaaagg gagagatggc    900

tccgattgga atgtcatccc tggctgaaga gtagaggaag cgaaaaaaag aagagttaaa    960

gaggcaaatg cagggaaccc gacgaggagg ctattgccgt agtagttcac atggtgaaaa   1020

gaatggagcg tttgtattaa tgattatgga ttcactcttt gaacaaattt ctggcagctt   1080

tttagttttg aaagtgagaa gtttcagact ctcactgaga ttagctttga agtttaaatc   1140

caatggagaa gactcaagaa acagtccaaa gaattcttct agaaccctat aaatacttac   1200

ttcagttacc aggtaaacaa gtgagaacca aactttcaca ggcatttaat cattggctga   1260

aagttccaga ggacaagcta cagattatta ttgaagtgac agaaatgttg cataatgcca   1320

gtttactcat cgatgatatt gaagacaact caaaactccg acgtggcttt ccagtggccc   1380

acagcatcta tggaatccca tctgtcatca attctgccaa ttacgtgtat ttccttggct   1440

tggagaaagt cttaaccctt gatcacccag atgcagtgaa gctttttacc cgccagcttt   1500

tggaactcca tcagggacaa ggcctagata tttactggag ggataattac acttgtccca   1560

ctgaagaaga atataaagct atggtgctgc agaaaacagg tggactgttt ggattagcag   1620

taggtctcat gcagttgttc tctgattaca aagaagattt aaaaccgcta cttaatacac   1680

ttgggctctt tttccaaatt agggatgatt atgctaatct acactccaaa gaatatagtg   1740

aaaacaaaag tttttgtgaa gatctgacag agggaaagtt ctcatttcct actattcatg   1800

ctatttggtc aaggcctgaa agcacccagg tgcagaatat cttgcgccag agaacagaaa   1860

acatagatat aaaaaaatac tgtgtacatt atcttgagga tgtaggttct tttgaataca   1920

ctcgtaatac ccttaaagag cttgaagcta aagcctataa acagattgat gcacgtggtg   1980

ggaaccctga gctagtagcc ttagtaaaac acttaagtaa gatgttcaaa gaagaaaatg   2040

aataatgtta agccattctt gattggacct catagcttat tttagttaat cttttttttg   2100

tcttttagcc ttaccacctt ttaaaaaatt tgttattctc cagaaacagt aaataggtga   2160

gtaggggtgg tgcaagtgaa ttcgttttca tttagaagcc cctctgtaca gataatcaaa   2220

attcaaagtt gaaagaatca aaagcagcca cagttatgta ggtctgattt gaatgtcata   2280

attgcagtga caggacattg ccaccaactc tatcctacta ccatcaatgt tgtgtttatt   2340

ccgtcaataa aaaagacttg cttccagg                                      2368


<210>  7466
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7466

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7467
<211>  3802
<212>  DNA
<213>  Homosapiens

<400>  7467
gagagtgagg acccggatgc tgaaccggat tgtgtatgaa ttttccatcc cctagcttta     60

agcgaggagg gagaggaagg gttggccaag tggggcggaa gggagcatct gagcgaggag    120

gaagcagaaa cctcaccgtt tcttcccctc cggactctgt gctagcactg tatacgtttg    180

cagttctctg cccagccgct gtggaaaatc ggcctcgaag tgattgaaat tccctgttta    240

tatcaggcgg cttctttcag atccatcgtc tttctcccgg agtatgaatg gaaggattca    300

gtatgcgctt cacatttgta tgtctctggc cattctcaaa ccaggccctt ccctttgaaa    360

agtcttttgc atgggatgtt cacttcttag acgcaaggtt gtgtgccctg gtttcatcgt    420

ctaacgcgtt agaaggcgct ttcatttctt catgggtgtt gagcgccgac cactggggtg    480

gcctctgcct tcgtagacct gcgcctggtg agacggacag atgctgaaca aaacgatgtg    540

aaattaccgc agtggcagtg ccccagagga gagttccacg gtgataggag aatgagggaa    600

tttggcttct ttagggaggg aaaggaaggg tttctgagca agtgaggatc gagctgagag    660

ctgaagggct agcaggagtt aactaaggaa agagaaaagg aaaagacatt ccagacaaaa    720

agactaactt gtcagaaagc cctgtggcgg aagggagctt ttccaatatg aagaactgag    780

cctggagaga tgggatgagg gggagtgtcg aaccttttag gctttgtaaa ggagttttgg    840

ttttctccta atagcaatgg gatatcttcc aaggaatctc aatcaaaagg gagagatggc    900

tccgattgga atgtcatccc tggctgaaga gtagaggaag cgaaaaaaag aagagttaaa    960

gaggcaaatg cagggaaccc gacgaggagg ctattgccgt agtagttcac atggtgaaaa   1020

gaatggagcg tttgtattaa tgattatgga ttcactcttt gaacaaattt ctggcagctt   1080

tttagttttg aaagtgagaa gtttcagact ctcactgaga ttagctttga agtttaaatc   1140

caatggagaa gactcaagaa acagtccaaa gaattcttct agaaccctat aaatacttac   1200

ttcagttacc aggtaaacaa gtgagaacca aactttcaca ggcatttaat cattggctga   1260

aagttccaga ggacaagcta cagattatta ttgaagtgac agaaatgttg cataatgcca   1320

gtttactcat cgatgatatt gaagacaact caaaactccg acgtggcttt ccagtggccc   1380

acagcatcta tggaatccca tctgtcatca attctgccaa ttacgtgtat ttccttggct   1440

tggagaaagt cttaaccctt gatcacccag atgcagtgaa gctttttacc cgccagcttt   1500

tggaactcca tcagggacaa ggcctagata tttactggag ggataattac acttgtccca   1560

ctgaagaaga atataaagct atggtgctgc agaaaacagg tggactgttt ggattagcag   1620

taggtctcat gcagttgttc tctgattaca aagaagattt aaaaccgcta cttaatacac   1680

ttgggctctt tttccaaatt agggatgatt atgctaatct acactccaaa gaatatagtg   1740

aaaacaaaag tttttgtgaa gatctgacag agggaaagtt ctcatttcct actattcatg   1800

ctatttggtc aaggcctgaa agcacccagg tgcagaatat cttgcgccag agaacagaaa   1860

acatagatat aaaaaaatac tgtgtacatt atcttgagga tgtaggttct tttgaataca   1920

ctcgtaatac ccttaaagag cttgaagcta aagcctataa acagattgat gcacgtggtg   1980

ggaaccctga gctagtagcc ttagtaaaac acttaagtaa gatgttcaaa gaagaaaatg   2040

aataatgtta agccattctt gattggacct catagcttat tttagttaat cttttttttg   2100

tcttttagcc ttaccacctt ttaaaaaatt tgttattctc cagaaacagt aaataggtga   2160

gtaggggtgg tgcaagtgaa ttcgttttca tttagaagcc cctctgtaca gataatcaaa   2220

attcaaagtt gaaagaatca aaagcagcca cagttatgta ggtctgattt gaatgtcata   2280

attgcagtga caggacattg ccaccaactc tatcctacta ccatcaatgt tgtgtttatt   2340

ccgtcaataa aaaagacttg cttccaggaa tttttatcca tacactttct aactgtacta   2400

tctgggcagt tccaagccag tttctattag ctagctggac caaagaccac aaatctcttt   2460

ttttcctaaa cgctgctgta aggaatatct cacttttccc cccggaaaca ccctcactga   2520

agtcttctat gaaaaggctg ataatgggct gggcgcggtg gctcacgcct gtaatcccag   2580

cactttggga ggccgaggcg ggcagatcac gaggtcagga gatcgagacc atcctgacac   2640

ggtgaaaccc tgtctctact aaaaatacaa aaaattagct gggcgtggtg gtgggcgcct   2700

gtagtcccag ctactcggga ggctgaggca ggagaatggt gtgaacccag gaggcggagc   2760

ttgcagtgag ccgagatagt gcctctgcac tccagcctgg gtgacagagc gagactccgt   2820

ctcaaaaaaa agggctgata atgataaaca gtgagcactc cggtcctttt tcttaggttt   2880

tccttttttc cttcctctcc accccacaag ttttgctttt taaccaaggt gtctctgctt   2940

gatgaaattc acatgctagt ctaaatcttt ttttctccct tgtaacattt atgtgcccca   3000

aactggttag tatatgggta cagcattccc tttccaattg ggaagcggaa aaagagagta   3060

tgggatattt tagaagggag cctttgaacc ttattatatt tccccatcat tgatagtgac   3120

aatcttaaaa gggttgtttt cttaccttaa gtacaaaagc atggaaaaat gcgcttttcc   3180

ttcccgccca catcaccacc ccgacttgaa gacagtaggt gcttgaatgg aaagtgagta   3240

ggcatcttta atcgccctga ttaaaggaaa gtgttagcct gagagggcct gactgaaaag   3300

taaccaaagg cttaatatca aacactaatt agctttttag tgccttaacc ctgacctggt   3360

taccagtttt ctgtagtttc tacacccaag ccactgaagt catctgtggc ccaagaggta   3420

ggacaaaaaa aaaaaaaaaa aaagctgatt tcaatatttg atttgttgac atcccaaaat   3480

gaaagtttta tgtttccctt agaaacatgt tttgcttggt tctatagtat gttacttagg   3540

atctatttac catatatttg tatgagaaat cctcacccaa gcattcaacc taaatctttg   3600

aaaagttggg tgctgtcttt agtaactttt aaaatagttt aaatctccca ttttaatagt   3660

gataaggaaa cctgttaaaa tcatggctat tgatgttata gtatggaaag ttgaacttta   3720

tgaacccata cttttaaaaa gcatttttaa aaatctaaca ctgactatag aaacaaatta   3780

aaatgtctac ctttaagtat aa                                            3802


<210>  7468
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7468

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7469
<211>  2298
<212>  DNA
<213>  Homosapiens

<400>  7469
aggagaatga gggaatttgg cttctttagg gagggaaagg aagggtttct gagcaagtga     60

ggatcgagct gagagctgaa gggctagcag gagttaacta aggaaagaga aaaggaaaag    120

acattccaga caaaaagact aacttgtcag aaagccctgt ggcggaaggg agcttttcca    180

atatgaagaa ctgagcctgg agagatggga tgagggggag tgtcgaacct tttaggcttt    240

gtaaaggagt tttggttttc tcctaatagc aatgggatat cttccaagga atctcaatca    300

aaagggagag atggctccga ttggaatgtc atccctggct gaagagtaga ggaagcgaaa    360

aaaagaagag ttaaagaggc aaatgcaggg aacccgacga ggaggctatt gccgtagtag    420

ttcacatggt gaaaagaatg gagcgtttgt attaatgatt atggattcac tctttgaaca    480

aatttctggc agctttttag ttttgaaagt gagaagtttc agactctcac tgaggtattc    540

tgtagttttt tcactctaaa aggaaactag tagagttcat gtaacacaca ctaatgcctc    600

tttacattta actttagtat gtgatagctg aaatttccag ctgtgataaa ttgggaaatc    660

ctttgattta aaagaaaaac aaaggcgggt gagggtgaga gtatatgcca cggtgtgtag    720

aatcctttag actcttaaga agacacaagg cggctgggcg tggtggctca cgcttgtaat    780

cccagcactt tgggaggccg aggcgggcgg atcacgaggt caggagatcg agaccatcct    840

ggctaacacg gtgaaagccc gtctctacta aaaatacaaa aaaattagcc gggcaaggtg    900

gcgggcgcct gtagtcccag ctactcggga ggctgaggca ggagaatggc gtgaacccgg    960

gaggcggagt ttgcagtgag acgagatcac gccactgcac tccagcctgg gcgacagagt   1020

gagacgctgt ttcagaagaa agacacaaga ttagctttga agtttaaatc caatggagaa   1080

gactcaagaa acagtccaaa gaattcttct agaaccctat aaatacttac ttcagttacc   1140

aggtaaacaa gtgagaacca aactttcaca ggcatttaat cattggctga aagttccaga   1200

ggacaagcta cagattatta ttgaagtgac agaaatgttg cataatgcca gtttactcat   1260

cgatgatatt gaagacaact caaaactccg acgtggcttt ccagtggccc acagcatcta   1320

tggaatccca tctgtcatca attctgccaa ttacgtgtat ttccttggct tggagaaagt   1380

cttaaccctt gatcacccag atgcagtgaa gctttttacc cgccagcttt tggaactcca   1440

tcagggacaa ggcctagata tttactggag ggataattac acttgtccca ctgaagaaga   1500

atataaagct atggtgctgc agaaaacagg tggactgttt ggattagcag taggtctcat   1560

gcagttgttc tctgattaca aagaagattt aaaaccgcta cttaatacac ttgggctctt   1620

tttccaaatt agggatgatt atgctaatct acactccaaa gaatatagtg aaaacaaaag   1680

tttttgtgaa gatctgacag agggaaagtt ctcatttcct actattcatg ctatttggtc   1740

aaggcctgaa agcacccagg tgcagaatat cttgcgccag agaacagaaa acatagatat   1800

aaaaaaatac tgtgtacatt atcttgagga tgtaggttct tttgaataca ctcgtaatac   1860

ccttaaagag cttgaagcta aagcctataa acagattgat gcacgtggtg ggaaccctga   1920

gctagtagcc ttagtaaaac acttaagtaa gatgttcaaa gaagaaaatg aataatgtta   1980

agccattctt gattggacct catagcttat tttagttaat cttttttttg tcttttagcc   2040

ttaccacctt ttaaaaaatt tgttattctc cagaaacagt aaataggtga gtaggggtgg   2100

tgcaagtgaa ttcgttttca tttagaagcc cctctgtaca gataatcaaa attcaaagtt   2160

gaaagaatca aaagcagcca cagttatgta ggtctgattt gaatgtcata attgcagtga   2220

caggacattg ccaccaactc tatcctacta ccatcaatgt tgtgtttatt ccgtcaataa   2280

aaaagacttg cttccagg                                                 2298


<210>  7470
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7470

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7471
<211>  3732
<212>  DNA
<213>  Homosapiens

<400>  7471
aggagaatga gggaatttgg cttctttagg gagggaaagg aagggtttct gagcaagtga     60

ggatcgagct gagagctgaa gggctagcag gagttaacta aggaaagaga aaaggaaaag    120

acattccaga caaaaagact aacttgtcag aaagccctgt ggcggaaggg agcttttcca    180

atatgaagaa ctgagcctgg agagatggga tgagggggag tgtcgaacct tttaggcttt    240

gtaaaggagt tttggttttc tcctaatagc aatgggatat cttccaagga atctcaatca    300

aaagggagag atggctccga ttggaatgtc atccctggct gaagagtaga ggaagcgaaa    360

aaaagaagag ttaaagaggc aaatgcaggg aacccgacga ggaggctatt gccgtagtag    420

ttcacatggt gaaaagaatg gagcgtttgt attaatgatt atggattcac tctttgaaca    480

aatttctggc agctttttag ttttgaaagt gagaagtttc agactctcac tgaggtattc    540

tgtagttttt tcactctaaa aggaaactag tagagttcat gtaacacaca ctaatgcctc    600

tttacattta actttagtat gtgatagctg aaatttccag ctgtgataaa ttgggaaatc    660

ctttgattta aaagaaaaac aaaggcgggt gagggtgaga gtatatgcca cggtgtgtag    720

aatcctttag actcttaaga agacacaagg cggctgggcg tggtggctca cgcttgtaat    780

cccagcactt tgggaggccg aggcgggcgg atcacgaggt caggagatcg agaccatcct    840

ggctaacacg gtgaaagccc gtctctacta aaaatacaaa aaaattagcc gggcaaggtg    900

gcgggcgcct gtagtcccag ctactcggga ggctgaggca ggagaatggc gtgaacccgg    960

gaggcggagt ttgcagtgag acgagatcac gccactgcac tccagcctgg gcgacagagt   1020

gagacgctgt ttcagaagaa agacacaaga ttagctttga agtttaaatc caatggagaa   1080

gactcaagaa acagtccaaa gaattcttct agaaccctat aaatacttac ttcagttacc   1140

aggtaaacaa gtgagaacca aactttcaca ggcatttaat cattggctga aagttccaga   1200

ggacaagcta cagattatta ttgaagtgac agaaatgttg cataatgcca gtttactcat   1260

cgatgatatt gaagacaact caaaactccg acgtggcttt ccagtggccc acagcatcta   1320

tggaatccca tctgtcatca attctgccaa ttacgtgtat ttccttggct tggagaaagt   1380

cttaaccctt gatcacccag atgcagtgaa gctttttacc cgccagcttt tggaactcca   1440

tcagggacaa ggcctagata tttactggag ggataattac acttgtccca ctgaagaaga   1500

atataaagct atggtgctgc agaaaacagg tggactgttt ggattagcag taggtctcat   1560

gcagttgttc tctgattaca aagaagattt aaaaccgcta cttaatacac ttgggctctt   1620

tttccaaatt agggatgatt atgctaatct acactccaaa gaatatagtg aaaacaaaag   1680

tttttgtgaa gatctgacag agggaaagtt ctcatttcct actattcatg ctatttggtc   1740

aaggcctgaa agcacccagg tgcagaatat cttgcgccag agaacagaaa acatagatat   1800

aaaaaaatac tgtgtacatt atcttgagga tgtaggttct tttgaataca ctcgtaatac   1860

ccttaaagag cttgaagcta aagcctataa acagattgat gcacgtggtg ggaaccctga   1920

gctagtagcc ttagtaaaac acttaagtaa gatgttcaaa gaagaaaatg aataatgtta   1980

agccattctt gattggacct catagcttat tttagttaat cttttttttg tcttttagcc   2040

ttaccacctt ttaaaaaatt tgttattctc cagaaacagt aaataggtga gtaggggtgg   2100

tgcaagtgaa ttcgttttca tttagaagcc cctctgtaca gataatcaaa attcaaagtt   2160

gaaagaatca aaagcagcca cagttatgta ggtctgattt gaatgtcata attgcagtga   2220

caggacattg ccaccaactc tatcctacta ccatcaatgt tgtgtttatt ccgtcaataa   2280

aaaagacttg cttccaggaa tttttatcca tacactttct aactgtacta tctgggcagt   2340

tccaagccag tttctattag ctagctggac caaagaccac aaatctcttt ttttcctaaa   2400

cgctgctgta aggaatatct cacttttccc cccggaaaca ccctcactga agtcttctat   2460

gaaaaggctg ataatgggct gggcgcggtg gctcacgcct gtaatcccag cactttggga   2520

ggccgaggcg ggcagatcac gaggtcagga gatcgagacc atcctgacac ggtgaaaccc   2580

tgtctctact aaaaatacaa aaaattagct gggcgtggtg gtgggcgcct gtagtcccag   2640

ctactcggga ggctgaggca ggagaatggt gtgaacccag gaggcggagc ttgcagtgag   2700

ccgagatagt gcctctgcac tccagcctgg gtgacagagc gagactccgt ctcaaaaaaa   2760

agggctgata atgataaaca gtgagcactc cggtcctttt tcttaggttt tccttttttc   2820

cttcctctcc accccacaag ttttgctttt taaccaaggt gtctctgctt gatgaaattc   2880

acatgctagt ctaaatcttt ttttctccct tgtaacattt atgtgcccca aactggttag   2940

tatatgggta cagcattccc tttccaattg ggaagcggaa aaagagagta tgggatattt   3000

tagaagggag cctttgaacc ttattatatt tccccatcat tgatagtgac aatcttaaaa   3060

gggttgtttt cttaccttaa gtacaaaagc atggaaaaat gcgcttttcc ttcccgccca   3120

catcaccacc ccgacttgaa gacagtaggt gcttgaatgg aaagtgagta ggcatcttta   3180

atcgccctga ttaaaggaaa gtgttagcct gagagggcct gactgaaaag taaccaaagg   3240

cttaatatca aacactaatt agctttttag tgccttaacc ctgacctggt taccagtttt   3300

ctgtagtttc tacacccaag ccactgaagt catctgtggc ccaagaggta ggacaaaaaa   3360

aaaaaaaaaa aaagctgatt tcaatatttg atttgttgac atcccaaaat gaaagtttta   3420

tgtttccctt agaaacatgt tttgcttggt tctatagtat gttacttagg atctatttac   3480

catatatttg tatgagaaat cctcacccaa gcattcaacc taaatctttg aaaagttggg   3540

tgctgtcttt agtaactttt aaaatagttt aaatctccca ttttaatagt gataaggaaa   3600

cctgttaaaa tcatggctat tgatgttata gtatggaaag ttgaacttta tgaacccata   3660

cttttaaaaa gcatttttaa aaatctaaca ctgactatag aaacaaatta aaatgtctac   3720

ctttaagtat aa                                                       3732


<210>  7472
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  7472

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  7473
<211>  1354
<212>  DNA
<213>  Homosapiens

<400>  7473
aatataatca cttgaatgaa gaattttcta attgagatat aatttacata ccacccattt     60

aaagtgtaca tttcagcagt ttttagtgta ttcacagggc tgtgcaacca tcacaattta    120

attttataac attttgatcc ctgcgaaaag aaaccctgta ctcattagca attagtccct    180

gttcctaacc actaatctac tttctttctc tgtagattgg cttattctga acatttcgta    240

taaatggaat catacaatat gtagtctctt gagattggct tctttcactt aacatgtttt    300

caaggcttca tagctgtaga atcttgcttt gtttttttga gatccagcct gggtgacaga    360

gcgagactcc gtctcaaaaa aaagggctga taatgataaa cagtgagcac tccggtcctt    420

tttcttaggt tttccttttt tccttcctct ccaccccaca agttttgctt tttaaccaag    480

gtgtctctgc ttgatgaaat tcacatgcta gtctaaatct ttttttctcc cttgtaacat    540

ttatgtgccc caaactggtt agtatatggg tacagcattc cctttccaat tgggaagcgg    600

aaaaagagag tatgggatat tttagaaggg agcctttgaa ccttattata tttccccatc    660

attgatagtg acaatcttaa aagggttgtt ttcttacctt aagtacaaaa gcatggaaaa    720

atgcgctttt ccttcccgcc cacatcacca ccccgacttg aagacagtag gtgcttgaat    780

ggaaagtgag taggcatctt taatcgccct gattaaagga aagtgttagc ctgagagggc    840

ctgactgaaa agtaaccaaa ggcttaatat caaacactaa ttagcttttt agtgccttaa    900

ccctgacctg gttaccagtt ttctgtagtt tctacaccca agccactgaa gtcatctgtg    960

gcccaagagg taggacaaaa aaaaaaaaaa aaaaagctga tttcaatatt tgatttgttg   1020

acatcccaaa atgaaagttt tatgtttccc ttagaaacat gttttgcttg gttctatagt   1080

atgttactta ggatctattt accatatatt tgtatgagaa atcctcaccc aagcattcaa   1140

cctaaatctt tgaaaagttg ggtgctgtct ttagtaactt ttaaaatagt ttaaatctcc   1200

cattttaata gtgataagga aacctgttaa aatcatggct attgatgtta tagtatggaa   1260

agttgaactt tatgaaccca tacttttaaa aagcattttt aaaaatctaa cactgactat   1320

agaaacaaat taaaatgtct acctttaagt ataa                               1354


<210>  7474
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  7474

Met Phe Pro Leu Glu Thr Cys Phe Ala Trp Phe Tyr Ser Met Leu Leu 
1               5                   10                  15      


Arg Ile Tyr Leu Pro Tyr Ile Cys Met Arg Asn Pro His Pro Ser Ile 
            20                  25                  30          


Gln Pro Lys Ser Leu Lys Ser Trp Val Leu Ser Leu Val Thr Phe Lys 
        35                  40                  45              


Ile Val 
    50  


<210>  7475
<211>  426
<212>  DNA
<213>  Homosapiens

<400>  7475
cgagaatgtc agcgacagta ttggaggcca gaggagtggt cagcccaccc aagccccgcc     60

tctgggcggg ggcccaagcg atttccgagt gctgaaacct gggatgacag agcagcccag    120

ggaaagcgcg tgttccagtt tactagatac cacagaagtt tttgcatttc tgacaagtgg    180

atggccccac cctgactcat caacctgggg atccacgaac caactcagtg caagaggaca    240

gcttctactt cttatgattt cacctctgac ccaaccagtc agcactcccc attccctggc    300

cccgtacctg tcaaactatc tgaaaaaccc cctaacctct gagcctttgg tgagatggat    360

ttgagtaaca actctgtctc ccacgtggca tggccagcct cgcgtcaatt aaactttctt    420

tactgc                                                               426


<210>  7476
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  7476

Met Thr Glu Gln Pro Arg Glu Ser Ala Cys Ser Ser Leu Leu Asp Thr 
1               5                   10                  15      


Thr Glu Val Phe Ala Phe Leu Thr Ser Gly Trp Pro His Pro Asp Ser 
            20                  25                  30          


Ser Thr Trp Gly Ser Thr Asn Gln Leu Ser Ala Arg Gly Gln Leu Leu 
        35                  40                  45              


Leu Leu Met Ile Ser Pro Leu Thr Gln Pro Val Ser Thr Pro His Ser 
    50                  55                  60                  


Leu Ala Pro Tyr Leu Ser Asn Tyr Leu Lys Asn Pro Leu Thr Ser Glu 
65                  70                  75                  80  


Pro Leu Val Arg Trp Ile 
                85      


<210>  7477
<211>  1966
<212>  DNA
<213>  Homosapiens

<400>  7477
attctcgtct atgctccagc agccgtacct cactccggtg gaggcgggac ttcctacagc     60

acttccggcc agagcctcaa gcttcgctgc tgggcagttg gctggagggg ctgctgctgg    120

gaacacctgg agtctccgcg ggcagatctc atattttgga ttctggatat attataatga    180

gtgacacttt gacagcggat gtcattggtc gaagagttga agttaatgga gaacatgcaa    240

cagtacgttt tgctggtgtt gtccctcccg tggcaggacc ctggttagga gtagaatggg    300

acaatcccga gagaggaaag catgatggga gccacgaagg gactgtgtat tttaaatgca    360

ggcacccgac aggaggatcc tttattcgtc cgaacaaggt aaattttgga acagactttc    420

ttactgcaat taagaaccgc tatgtgttag aagatggacc agaggaagat agaaaagagc    480

aaattgttac aattggaaat aaacctgtgg agactatcgg ttttgactct attatgaaac    540

agcaaagtca gctgagcaag ttgcaagaag tttctctgag gaactgtgca gtaagttgtg    600

ctggtgaaaa aggaggagtt gctgaagcat gtcctaatat cagaaaggta gatttgtcaa    660

aaaacctgtt gtcatcatgg gatgaagtga tacacattgc tgatcagctc agacacctgg    720

aagtccttaa tgtcagtgaa aataaactaa aatttccctc cggttcagta ttaactggaa    780

cgctttctgt actgaaggtt ttagtcctca atcaaacagg aataacgtgg gctgaggtgc    840

tgcggtgtgt cgcggggtgc ccaggcctgg aggaactcta ccttgagtct aacaacattt    900

tcatttccga aaggccaaca gatgttctcc agacagtcaa gttattagat ctttcctcta    960

atcaattaat tgatgaaaat cagctgtatc tgatagccca cctgcccagg ttagaacaat   1020

taatcctctc tgacactgga atttcttctc tacattttcc ggatgctgga attgggtgca   1080

aaacgtccat gttcccatcc ttgaagtacc tggtagtaaa cgacaatcag atatcacaat   1140

ggtcgttttt caatgagcta gagaagttac caagtctacg ggctttgtcc tgcctaagaa   1200

accccctgac caaagaggac aaagaagcag agacggcgcg actactcatt atcgccagca   1260

ttggccagct gaagacgctg aacaaatgtg agattctccc cgaggagagg cggagagctg   1320

agcttgacta ccgaaaagct tttggaaatg agtggaaaca ggctggtgga cataaggatc   1380

cggaaaaaaa cagactcagc gaagaattcc tcacagccca tcccagatac cagttcctct   1440

gcctgaaata tggtgcacct gaagattggg aactcaaaac acagcaacca cttatgctga   1500

aaaaccagct actaacactg aagataaaat accctcatca acttgatcag aaagtcctgg   1560

agaaacaact gccgggctcc atgacaattc aaaaggtgaa gggattgctg tcacgtcttc   1620

tcaaagttcc tgtgtcagac cttctgttgt cctatgaaag tcccaaaaag ccgggcagag   1680

aaatcgagct ggaaaatgac ctaaagtcat tacagtttta ttctgtggaa aatggagatt   1740

gtctattagt gcgatggtga caaccaacta ataaaattta aagaccacac tgcttatcgt   1800

gtctggggtt caccggaaat aaatgattca ctggaacaat tctactgtca aaacaaaggg   1860

ggtttacaac ttgtcctaag tataacaagg gatgtatttt ttgttgggaa gtgaccattt   1920

ctaggcttat acataatagc aataataaag gctttgaacc tactaa                  1966


<210>  7478
<211>  527
<212>  PRT
<213>  Homosapiens

<400>  7478

Met Ser Asp Thr Leu Thr Ala Asp Val Ile Gly Arg Arg Val Glu Val 
1               5                   10                  15      


Asn Gly Glu His Ala Thr Val Arg Phe Ala Gly Val Val Pro Pro Val 
            20                  25                  30          


Ala Gly Pro Trp Leu Gly Val Glu Trp Asp Asn Pro Glu Arg Gly Lys 
        35                  40                  45              


His Asp Gly Ser His Glu Gly Thr Val Tyr Phe Lys Cys Arg His Pro 
    50                  55                  60                  


Thr Gly Gly Ser Phe Ile Arg Pro Asn Lys Val Asn Phe Gly Thr Asp 
65                  70                  75                  80  


Phe Leu Thr Ala Ile Lys Asn Arg Tyr Val Leu Glu Asp Gly Pro Glu 
                85                  90                  95      


Glu Asp Arg Lys Glu Gln Ile Val Thr Ile Gly Asn Lys Pro Val Glu 
            100                 105                 110         


Thr Ile Gly Phe Asp Ser Ile Met Lys Gln Gln Ser Gln Leu Ser Lys 
        115                 120                 125             


Leu Gln Glu Val Ser Leu Arg Asn Cys Ala Val Ser Cys Ala Gly Glu 
    130                 135                 140                 


Lys Gly Gly Val Ala Glu Ala Cys Pro Asn Ile Arg Lys Val Asp Leu 
145                 150                 155                 160 


Ser Lys Asn Leu Leu Ser Ser Trp Asp Glu Val Ile His Ile Ala Asp 
                165                 170                 175     


Gln Leu Arg His Leu Glu Val Leu Asn Val Ser Glu Asn Lys Leu Lys 
            180                 185                 190         


Phe Pro Ser Gly Ser Val Leu Thr Gly Thr Leu Ser Val Leu Lys Val 
        195                 200                 205             


Leu Val Leu Asn Gln Thr Gly Ile Thr Trp Ala Glu Val Leu Arg Cys 
    210                 215                 220                 


Val Ala Gly Cys Pro Gly Leu Glu Glu Leu Tyr Leu Glu Ser Asn Asn 
225                 230                 235                 240 


Ile Phe Ile Ser Glu Arg Pro Thr Asp Val Leu Gln Thr Val Lys Leu 
                245                 250                 255     


Leu Asp Leu Ser Ser Asn Gln Leu Ile Asp Glu Asn Gln Leu Tyr Leu 
            260                 265                 270         


Ile Ala His Leu Pro Arg Leu Glu Gln Leu Ile Leu Ser Asp Thr Gly 
        275                 280                 285             


Ile Ser Ser Leu His Phe Pro Asp Ala Gly Ile Gly Cys Lys Thr Ser 
    290                 295                 300                 


Met Phe Pro Ser Leu Lys Tyr Leu Val Val Asn Asp Asn Gln Ile Ser 
305                 310                 315                 320 


Gln Trp Ser Phe Phe Asn Glu Leu Glu Lys Leu Pro Ser Leu Arg Ala 
                325                 330                 335     


Leu Ser Cys Leu Arg Asn Pro Leu Thr Lys Glu Asp Lys Glu Ala Glu 
            340                 345                 350         


Thr Ala Arg Leu Leu Ile Ile Ala Ser Ile Gly Gln Leu Lys Thr Leu 
        355                 360                 365             


Asn Lys Cys Glu Ile Leu Pro Glu Glu Arg Arg Arg Ala Glu Leu Asp 
    370                 375                 380                 


Tyr Arg Lys Ala Phe Gly Asn Glu Trp Lys Gln Ala Gly Gly His Lys 
385                 390                 395                 400 


Asp Pro Glu Lys Asn Arg Leu Ser Glu Glu Phe Leu Thr Ala His Pro 
                405                 410                 415     


Arg Tyr Gln Phe Leu Cys Leu Lys Tyr Gly Ala Pro Glu Asp Trp Glu 
            420                 425                 430         


Leu Lys Thr Gln Gln Pro Leu Met Leu Lys Asn Gln Leu Leu Thr Leu 
        435                 440                 445             


Lys Ile Lys Tyr Pro His Gln Leu Asp Gln Lys Val Leu Glu Lys Gln 
    450                 455                 460                 


Leu Pro Gly Ser Met Thr Ile Gln Lys Val Lys Gly Leu Leu Ser Arg 
465                 470                 475                 480 


Leu Leu Lys Val Pro Val Ser Asp Leu Leu Leu Ser Tyr Glu Ser Pro 
                485                 490                 495     


Lys Lys Pro Gly Arg Glu Ile Glu Leu Glu Asn Asp Leu Lys Ser Leu 
            500                 505                 510         


Gln Phe Tyr Ser Val Glu Asn Gly Asp Cys Leu Leu Val Arg Trp 
        515                 520                 525         


<210>  7479
<211>  1862
<212>  DNA
<213>  Homosapiens

<400>  7479
ctcaagcttc gctgctgggc agttggctgg aggggctgct gctgggaaca cctggagtct     60

ccgcgggcag atctcatatt ttggattctg gatatattat aatgagtgac actttgacag    120

cggatgtcat tggtcgaaga gttgaagtta atggagaaca tgcaacagta cgttttgctg    180

gtgttgtccc tcccgtggca ggcacccgac aggaggatcc tttattcgtc cgaacaaggt    240

aaattttgga acagactttc ttactgcaat taagaaccgc tatgtgttag aagatggacc    300

agaggaagat agaaaagagc aaattgttac aattggaaat aaacctgtgg agactatcgg    360

ttttgactct attatgaaac agcaaagggc cagtggatag catacgtgct tatgtatcca    420

tgtgaactct gtttttcatg cagtcagctg agcaagttgc aagaagtttc tctgaggaac    480

tgtgcagtaa gttgtgctgg tgaaaaagga ggagttgctg aagcatgtcc taatatcaga    540

aaggtagatt tgtcaaaaaa cctgttgtca tcatgggatg aagtgataca cattgctgat    600

cagctcagac acctggaagt ccttaatgtc agtgaaaata aactaaaatt tccctccggt    660

tcagtattaa ctggaacgct ttctgtactg aaggttttag tcctcaatca aacaggaata    720

acgtgggctg aggtgctgcg gtgtgtcgcg gggtgcccag gcctggagga actctacctt    780

gagtctaaca acattttcat ttccgaaagg ccaacagatg ttctccagac agtcaagtta    840

ttagatcttt cctctaatca attaattgat gaaaatcagc tgtatctgat agcccacctg    900

cccaggttag aacaattaat cctctctgac actggaattt cttctctaca ttttccggat    960

gctggaattg ggtgcaaaac gtccatgttc ccatccttga agtacctggt agtaaacgac   1020

aatcagatat cacaatggtc gtttttcaat gagctagaga agttaccaag tctacgggct   1080

ttgtcctgcc taagaaaccc cctgaccaaa gaggacaaag aagcagagac ggcgcgacta   1140

ctcattatcg ccagcattgg ccagctgaag acgctgaaca aatgtgagat tctccccgag   1200

gagaggcgga gagctgagct tgactaccga aaagcttttg gaaatgagtg gaaacaggct   1260

ggtggacata aggatccgga aaaaaacaga ctcagcgaag aattcctcac agcccatccc   1320

agataccagt tcctctgcct gaaatatggt gcacctgaag attgggaact caaaacacag   1380

caaccactta tgctgaaaaa ccagctacta acactgaaga taaaataccc tcatcaactt   1440

gatcagaaag tcctggagaa acaactgccg ggctccatga caattcaaaa ggtgaaggga   1500

ttgctgtcac gtcttctcaa agttcctgtg tcagaccttc tgttgtccta tgaaagtccc   1560

aaaaagccgg gcagagaaat cgagctggaa aatgacctaa agtcattaca gttttattct   1620

gtggaaaatg gagattgtct attagtgcga tggtgacaac caactaataa aatttaaaga   1680

ccacactgct tatcgtgtct ggggttcacc ggaaataaat gattcactgg aacaattcta   1740

ctgtcaaaac aaagggggtt tacaacttgt cctaagtata acaagggatg tattttttgt   1800

tgggaagtga ccatttctag gcttatacat aatagcaata ataaaggctt tgaacctact   1860

aa                                                                  1862


<210>  7480
<211>  414
<212>  PRT
<213>  Homosapiens

<400>  7480

Met Tyr Pro Cys Glu Leu Cys Phe Ser Cys Ser Gln Leu Ser Lys Leu 
1               5                   10                  15      


Gln Glu Val Ser Leu Arg Asn Cys Ala Val Ser Cys Ala Gly Glu Lys 
            20                  25                  30          


Gly Gly Val Ala Glu Ala Cys Pro Asn Ile Arg Lys Val Asp Leu Ser 
        35                  40                  45              


Lys Asn Leu Leu Ser Ser Trp Asp Glu Val Ile His Ile Ala Asp Gln 
    50                  55                  60                  


Leu Arg His Leu Glu Val Leu Asn Val Ser Glu Asn Lys Leu Lys Phe 
65                  70                  75                  80  


Pro Ser Gly Ser Val Leu Thr Gly Thr Leu Ser Val Leu Lys Val Leu 
                85                  90                  95      


Val Leu Asn Gln Thr Gly Ile Thr Trp Ala Glu Val Leu Arg Cys Val 
            100                 105                 110         


Ala Gly Cys Pro Gly Leu Glu Glu Leu Tyr Leu Glu Ser Asn Asn Ile 
        115                 120                 125             


Phe Ile Ser Glu Arg Pro Thr Asp Val Leu Gln Thr Val Lys Leu Leu 
    130                 135                 140                 


Asp Leu Ser Ser Asn Gln Leu Ile Asp Glu Asn Gln Leu Tyr Leu Ile 
145                 150                 155                 160 


Ala His Leu Pro Arg Leu Glu Gln Leu Ile Leu Ser Asp Thr Gly Ile 
                165                 170                 175     


Ser Ser Leu His Phe Pro Asp Ala Gly Ile Gly Cys Lys Thr Ser Met 
            180                 185                 190         


Phe Pro Ser Leu Lys Tyr Leu Val Val Asn Asp Asn Gln Ile Ser Gln 
        195                 200                 205             


Trp Ser Phe Phe Asn Glu Leu Glu Lys Leu Pro Ser Leu Arg Ala Leu 
    210                 215                 220                 


Ser Cys Leu Arg Asn Pro Leu Thr Lys Glu Asp Lys Glu Ala Glu Thr 
225                 230                 235                 240 


Ala Arg Leu Leu Ile Ile Ala Ser Ile Gly Gln Leu Lys Thr Leu Asn 
                245                 250                 255     


Lys Cys Glu Ile Leu Pro Glu Glu Arg Arg Arg Ala Glu Leu Asp Tyr 
            260                 265                 270         


Arg Lys Ala Phe Gly Asn Glu Trp Lys Gln Ala Gly Gly His Lys Asp 
        275                 280                 285             


Pro Glu Lys Asn Arg Leu Ser Glu Glu Phe Leu Thr Ala His Pro Arg 
    290                 295                 300                 


Tyr Gln Phe Leu Cys Leu Lys Tyr Gly Ala Pro Glu Asp Trp Glu Leu 
305                 310                 315                 320 


Lys Thr Gln Gln Pro Leu Met Leu Lys Asn Gln Leu Leu Thr Leu Lys 
                325                 330                 335     


Ile Lys Tyr Pro His Gln Leu Asp Gln Lys Val Leu Glu Lys Gln Leu 
            340                 345                 350         


Pro Gly Ser Met Thr Ile Gln Lys Val Lys Gly Leu Leu Ser Arg Leu 
        355                 360                 365             


Leu Lys Val Pro Val Ser Asp Leu Leu Leu Ser Tyr Glu Ser Pro Lys 
    370                 375                 380                 


Lys Pro Gly Arg Glu Ile Glu Leu Glu Asn Asp Leu Lys Ser Leu Gln 
385                 390                 395                 400 


Phe Tyr Ser Val Glu Asn Gly Asp Cys Leu Leu Val Arg Trp 
                405                 410                 


<210>  7481
<211>  510
<212>  DNA
<213>  Homosapiens

<400>  7481
taaataagta ggccgggcgc ggtggctcac acctgtaatc ccagcacttt aggaggccga     60

gacaggcgga tcacctgagg tcaggagttc gagaccagcc tggccaacat ggtgaaaccc    120

cgtctctact aaaaatacaa aaattagcca ggtgtgctgg caggcgactg tcagctactt    180

gagaggctga ggcaagagaa tcgcttgaac ccccgaggca gatgttgcag tgagccgaaa    240

tcacgccatc gcactccagc ctgggggaca agagcaagac ttcgtctcaa aaaaaaaaaa    300

aaaaagtaaa taagtaaata acaaataaag catatacagt cttttatgga actacaacgt    360

tggaatctat agcctgcccc tttagtaatt ttcacatttg gctacgaact tttattttat    420

tttattttat ttattttttt gagatggagt ctcactctgt cacccaggct ggagtacatg    480

agcccagatc gcgccactgc actccagcct                                     510


<210>  7482
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  7482

Pro Gly Val Leu Ala Gly Asp Cys Gln Leu Leu Glu Arg Leu Arg Gln 
1               5                   10                  15      


Glu Asn Arg Leu Asn Pro Arg Gly Arg Cys Cys Ser Glu Pro Lys Ser 
            20                  25                  30          


Arg His Arg Thr Pro Ala Trp Gly Thr Arg Ala Arg Leu Arg Leu Lys 
        35                  40                  45              


Lys Lys Lys Lys Lys 
    50              


<210>  7483
<211>  337
<212>  DNA
<213>  Homosapiens

<400>  7483
agtaagttgt gctggtgaaa aaggaggagt tgctgaagca tgtcctagta tccttttcac     60

cgagagcttg ttattggaat ctgactatgg attttatacc tgtgccagag actgctaatt    120

gcctacccat tgtccagtct tgacaacttc cttcctaatg cagttcagtt ttgcttggtg    180

tagttggggc ccagataaat tatttacctt cccagacccc tttgcttgca agtttgccag    240

catgttcagg tggaagtttc tacaccgggc tccttgaaag ggggcacacg cgcctggcct    300

cacaatgaac tttttcgttt ctcagtgaag ttttgga                             337


<210>  7484
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  7484

Met Gln Phe Ser Phe Ala Trp Cys Ser Trp Gly Pro Asp Lys Leu Phe 
1               5                   10                  15      


Thr Phe Pro Asp Pro Phe Ala Cys Lys Phe Ala Ser Met Phe Arg Trp 
            20                  25                  30          


Lys Phe Leu His Arg Ala Pro 
        35                  


<210>  7485
<211>  576
<212>  DNA
<213>  Homosapiens

<400>  7485
cagctggaac aaagtttttt cttgggtatc aaaagaggtt ctcagtgttg cttttgccct     60

tcttcctttc ctgggcttct tgtattcatc tgaatggact ataggcactt tcctggggcg    120

agggcggcag ggcaagagca gtatctttca gcaggaggaa cctgggagac tgtttatgtt    180

cttgaaatgg agaggtttgc atttggggaa gggaaagcaa ttcttttatt tttaagagat    240

ggagttggcc gggcgcggtg gctcaggcct gtaatccccg cctcggcctg tcaaagtgct    300

gagattatag gtgtgagcca ccgtgcgtag caggaaagca tttctttttc tttttttttc    360

ttttgagaca gagtcttgct ctgtcaccca ggctggagtg cagtggcaca atctcagctc    420

attgcaacct ccacctcctg ggttcaagtg attctcctcc ctcagcttcc agagtagctg    480

ggactacagg cgcacaccac catgcctggc taatttttgt atatttattt tttgagacgg    540

agcctcgctc tgtcgcccag gctggagtgc agtgcc                              576


<210>  7486
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  7486

Met Asp Tyr Arg His Phe Pro Gly Ala Arg Ala Ala Gly Gln Glu Gln 
1               5                   10                  15      


Tyr Leu Ser Ala Gly Gly Thr Trp Glu Thr Val Tyr Val Leu Glu Met 
            20                  25                  30          


Glu Arg Phe Ala Phe Gly Glu Gly Lys Ala Ile Leu Leu Phe Leu Arg 
        35                  40                  45              


Asp Gly Val Gly Arg Ala Arg Trp Leu Arg Pro Val Ile Pro Ala Ser 
    50                  55                  60                  


Ala Cys Gln Ser Ala Glu Ile Ile Gly Val Ser His Arg Ala 
65                  70                  75              


<210>  7487
<211>  1236
<212>  DNA
<213>  Homosapiens

<400>  7487
ccagcctggc actgcacggt ctggtggaaa cgtgagaagt gtcctgtgga tcgtgtctca     60

ggtggcacca ggtttctgtc agcgcagaaa gagaactgtt accaaaggtg acactcgggg    120

aaaacatttg aagtatttga aggcagtctt ctcttgctag ttttgagtca ggacacctaa    180

ggaacaatga tgtaatacac atgtaaacat gttgcttttc atttgttgtc ttttgttgag    240

tttcactggt cattaacaat gagctagata agctacagag tctgcagctc tgggtagata    300

gaagattctg cccttggaag tggtcgttgt ccatcactcc taaaaatcac actgaataaa    360

ggcagctcca tgtgtcctgg gaaaggcaca ggctctctgg acgcttacct atcctttgtt    420

tgtttgtttg ttttgttttt acttatagtg gcctttggtt tatcattcat ctcttttgct    480

ttcttaaaca gaatatggtg cacctgaaga ttgggaactc aaaacacagc aaccacttat    540

gctgaaaaac cagctactaa cactgaagat aaaataccct catcaacttg atcagaaagt    600

cctggagaaa caactgccgg gctccatgac aattcaaaag gtgaagggat tgctgtcacg    660

tcttctcaaa gttcctgtgt cagaccttct gttgtcctat gaaagtccca aagtaagttg    720

cccagcaaaa tacaaagtca aagtcaagct tagtcctcgt attatgacat taaactgtct    780

ctagatagca acagtttgat tctaaatgga gaccatgggt ctgtttgttt gattttaagg    840

gtaagctact gcctggggac ggggtggggg aagagtatgt gtagcatgct ttatcggatc    900

tgtcttaatc acatccttcc ccaccttcgt tctaatttta gaagccgggc agagaaatcg    960

agctggaaaa tgacctaaag tcattacagt tttattctgt ggaaaatgga gattgtctat   1020

tagtgcgatg gtgacaacca actaataaaa tttaaagacc acactgctta tcgtgtctgg   1080

ggttcaccgg aaataaatga ttcactggaa caattctact gtcaaaacaa agggggttta   1140

caacttgtcc taagtataac aagggatgta ttttttgttg ggaagtgacc atttctaggc   1200

ttatacataa tagcaataat aaaggctttg aaccta                             1236


<210>  7488
<211>  81
<212>  PRT
<213>  Homosapiens

<400>  7488

Met Leu Lys Asn Gln Leu Leu Thr Leu Lys Ile Lys Tyr Pro His Gln 
1               5                   10                  15      


Leu Asp Gln Lys Val Leu Glu Lys Gln Leu Pro Gly Ser Met Thr Ile 
            20                  25                  30          


Gln Lys Val Lys Gly Leu Leu Ser Arg Leu Leu Lys Val Pro Val Ser 
        35                  40                  45              


Asp Leu Leu Leu Ser Tyr Glu Ser Pro Lys Val Ser Cys Pro Ala Lys 
    50                  55                  60                  


Tyr Lys Val Lys Val Lys Leu Ser Pro Arg Ile Met Thr Leu Asn Cys 
65                  70                  75                  80  


Leu 
    


<210>  7489
<211>  1010
<212>  DNA
<213>  Homosapiens

<400>  7489
ccagcctggc actgcacggt ctggtggaaa cgtgagaagt gtcctgtgga tcgtgtctca     60

ggtggcacca ggtttctgtc agcgcagaaa gagaactgtt accaaaggtg acactcgggg    120

aaaacatttg aagtatttga aggcagtctt ctcttgctag ttttgagtca ggacacctaa    180

ggaacaatga tgtaatacac atgtaaacat gttgcttttc atttgttgtc ttttgttgag    240

tttcactggt cattaacaat gagctagata agctacagag tctgcagctc tgggtagata    300

gaagattctg cccttggaag tggtcgttgt ccatcactcc taaaaatcac actgaataaa    360

ggcagctcca tgtgtcctgg gaaaggcaca ggctctctgg acgcttacct atcctttgtt    420

tgtttgtttg ttttgttttt acttatagtg gcctttggtt tatcattcat ctcttttgct    480

ttcttaaaca gaatatggtg cacctgaaga ttgggaactc aaaacacagc aaccacttat    540

gctgaaaaac cagctactaa cactgaagat aaaataccct catcaacttg atcagaaagt    600

cctggagaaa caactgccgg gctccatgac aattcaaaag gtgaagggat tgctgtcacg    660

tcttctcaaa gttcctgtgt cagaccttct gttgtcctat gaaagtccca aaaagccggg    720

cagagaaatc gagctggaaa atgacctaaa gtcattacag ttttattctg tggaaaatgg    780

agattgtcta ttagtgcgat ggtgacaacc aactaataaa atttaaagac cacactgctt    840

atcgtgtctg gggttcaccg gaaataaatg attcactgga acaattctac tgtcaaaaca    900

aagggggttt acaacttgtc ctaagtataa caagggatgt attttttgtt gggaagtgac    960

catttctagg cttatacata atagcaataa taaaggcttt gaacctacta              1010


<210>  7490
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  7490

Met Leu Lys Asn Gln Leu Leu Thr Leu Lys Ile Lys Tyr Pro His Gln 
1               5                   10                  15      


Leu Asp Gln Lys Val Leu Glu Lys Gln Leu Pro Gly Ser Met Thr Ile 
            20                  25                  30          


Gln Lys Val Lys Gly Leu Leu Ser Arg Leu Leu Lys Val Pro Val Ser 
        35                  40                  45              


Asp Leu Leu Leu Ser Tyr Glu Ser Pro Lys Lys Pro Gly Arg Glu Ile 
    50                  55                  60                  


Glu Leu Glu Asn Asp Leu Lys Ser Leu Gln Phe Tyr Ser Val Glu Asn 
65                  70                  75                  80  


Gly Asp Cys Leu Leu Val Arg Trp 
                85              


<210>  7491
<211>  500
<212>  DNA
<213>  Homosapiens

<400>  7491
cactgaagat aaaataccct catcaacttg atcagaaagt cctggagaaa caactgccgg     60

gtaagaagaa ccagcctgtc ttttccttaa actctgaatc atcggcctag gctccatgac    120

aattcaaaag gtgaagggat tgctgtcacg tcttctcaaa gttcctgtgt cagaccttct    180

gttgtcctat gaaagtccca aaaagccggg cagagaaatc gagctggaaa atgacctaaa    240

gtcattacag ttttattctg tggaaaatgg agattgtcta ttagtgcgat ggtgacaacc    300

aactaataaa atttaaagac cacactgctt atcgtgtctg gggttcaccg gaaataaatg    360

attcactgga acaattctac tgtcaaaaca aagggggttt acaacttgtc ctaagtataa    420

caagggatgt attttttgtt gggaagtgac catttctagg cttatacata atagcaataa    480

taaaggcttt gaacctacta                                                500


<210>  7492
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  7492

Met Thr Ile Gln Lys Val Lys Gly Leu Leu Ser Arg Leu Leu Lys Val 
1               5                   10                  15      


Pro Val Ser Asp Leu Leu Leu Ser Tyr Glu Ser Pro Lys Lys Pro Gly 
            20                  25                  30          


Arg Glu Ile Glu Leu Glu Asn Asp Leu Lys Ser Leu Gln Phe Tyr Ser 
        35                  40                  45              


Val Glu Asn Gly Asp Cys Leu Leu Val Arg Trp 
    50                  55                  


<210>  7493
<211>  3689
<212>  DNA
<213>  Homosapiens

<400>  7493
gtagaaaggt ggtttatgat gggagtggct atggttttgt ctttacaaat aaaatagcat     60

taaaattttt acatttaaac tttatgggcc atgtataggg tgaagatgta agcatgggca    120

tctggatggc tgccatagga cctaaaagat accaggacag tctgtggctg tgtgagaaga    180

cctgtgagac aggaatgctg tcttctcctc agtattctcc gtgggaactg acggaactgt    240

ggaaactgaa ggaacggtgc ggtgatcctt gtcgatgtca agcaagataa cagggacttg    300

aattagcaga gtctaaaatc agggcaggca aacgataatc tgagtgcaag tctgaggagt    360

cccagggttt agcagtagac tgtatggtct ttcaagagag ttccagactg gcactttcac    420

ccagaaccaa tgcggtgttt cttaatgttt gcacaaattt ccttaaaaat caacttgtac    480

tgtagcataa gaaaagtttt tatttatcta ttggaagatt atcagaaaaa taccaagtta    540

ttttataaaa gaaaaaatat ttctaaatcc tgatgcattg tggctaatta gtaattcacc    600

attacctata gtttttggtt aaaacttggc ctagttcaga aatctgtagt agtaactgag    660

agtttgaatt tcaacctgga ttgcaggata gctctgtaga gctaattagg ataattatca    720

gacaaaaagg aactcacagg aatgctgtgt gatcatgtga tcacatattt gagcagtggt    780

cacttatacc aaagtttggg gtttctggaa ataatgtcag attttgtgga tctctgaagt    840

gggcaacttg aactaacttg aagaggaacc aatatgattc tcagttctga accttggttt    900

taaagaagtt catttatatg gtagactaat acccaaattt tctttctgcc atctaacata    960

aatcctgaag gtcacagttt agtactcata gtttttaaat gctaaagttg tgtgagtatg   1020

aataaaagca aatacctctc agggttttag tgccatcggg aaggatattt ctaaattttg   1080

ttgacatttt gaaagaatta gttttgcttt cctcctatca ttgcctaatg tttacctaat   1140

atgagtacat ttcaatcaaa gctggttatc acagaagaag atatactcag cttaggtata   1200

attgtaggga aaagcatgtg attaatttaa gtactcttag aaatagtgca actgagaaga   1260

cagataatag catattgtta tacatagtag aggatgtctc cccaagttta agggacattt   1320

cccaaaatga ccaaccaaat catttctagt aaccctttaa aatagtagtt tcaatagaga   1380

attccattaa aactagtctt atgacagata ttaactgtgt tcagatttta ttaggctagc   1440

tagtttcttt ctatttaata tttaaatctt atcatgaaat gcagtgatga gctgtaaaaa   1500

taaatatgaa ataagatcag aaaatcatta gtaggttcaa agcctttatt attgctatta   1560

tgtataagcc tagaaatggt cacttcccaa caaaaaatac atcccttgtt atacttagga   1620

caagttgtaa accccctttg ttttgacagt agaattgttc cagtgaatca tttatttccg   1680

gtgaacccca gacacgataa gcagtgtggt ctttaaattt tattagttgg ttgtcaccat   1740

cgcactaata gacaatctcc attttccaca gaataaaact gtaatgactt taggtcattt   1800

tccagctcga tttctctgcc cggcttctaa aattagaacg aaggtgggga aggatgtgat   1860

taagacagat ccgataaagc atgctacaca tactcttccc ccaccccgtc cccaggcagt   1920

agcttaccct taaaatcaaa caaacagacc catggtctcc atttagaatc aaactgttgc   1980

tatctagaga cagtttaatg tcataatacg aggactaagc ttgactttga ctttgtattt   2040

tgctgggcaa cttactttgg gactttcata ggacaacaga aggtctgaca caggaacttt   2100

gagaagacgt gacagcaatc ccttcacctt ttgaattgtc atggagccta tcaaaagaca   2160

agaaaagtcc attcgttctc tcaaatgaca gttacctgta aaactagctc atgtgatgag   2220

accacagtat cattgcaatg atagctgtat ctgtcttttt tttttttttt tttttgagac   2280

tgacttactt acttacttaa gtaagtcttg ctctgtcgcc caggctggag tgcaatggtg   2340

taatctcggc tcactgcaac ctccgcttcc cgggttcaaa caattctcct gcctcagcct   2400

cctgagtagc tggtgcccat caccacaccc agctaacttt tgtattttta gtagagacgg   2460

ggtttcacca tgttggccag gctggtcttg aactcctgac ctcgtgatcc gcccgccctg   2520

gccccccaaa gtgctgggat tacaagcatg agcccagcgc ctggctgtat ctttcatttt   2580

acccaagtca ctttacccaa gtaagtaatt aggggaaagc ctgagtcttg taccacctgt   2640

tcatttgggg aactgtggga aacggagcca acggacctaa gtgccctttg acagtgagtt   2700

tcataccatt tcagtagtgt atttctttct taatctgaat aaaccagaat gatactctca   2760

gcacagaaga ataaagggag cgagtcatta acgttttctt tttaaacctt tatgatgact   2820

tccttatgaa ttactgaacg aacactggaa tgggactcag gtatcctgag gacatctctc   2880

aactctggcc ttagttcccc ctctgtaaaa ttagggtgcc aactaaatga tctacaaggt   2940

cccttccagc gccgccattc tgtaattaca tcatgtgtaa ctgtattaaa catacacaag   3000

tgactgccag gcatgggaat gtaacttccg agtaaatgct ttggtttgtt cagaatacac   3060

tatgaacttc tttccaaaga cgggttgtgg taaatagtgg atattttgat tataagaaat   3120

agagtttcct tgaagcttta gctggagata cagcaatagt gtggtgttcc tacaaatatc   3180

acagtgtatt caaacatatt tttctatcaa aaatcatttt tgtaaaagct gtgtgttttt   3240

atccaacttg tgataataaa tgttctttat tttagaataa aaactggcct ttttgtatgt   3300

attgaataca gttaatagaa tttataattt taattaacaa tttgctcttt catgtgtgaa   3360

tatgtgatag tctagtcctt tcaaaagatt gagacggact ggctttcatt gtttgaaggc   3420

tggtgagaga aggggttacc tgctgcacac cagtggggag tgacatactc ctaacacatg   3480

ccagaaacaa aaagtttggt cataaaacag ttctaataag aaatctgcct ggcctgctca   3540

cacctgtaac cccagcactt tgggaggcag agggatcaga gcccaggaat ttgagaccag   3600

cctgggcaac atgaggatac cccatctcta caaaaaataa aaaattagcc aagcatagcg   3660

atgtacgcct ctagtcccag ctacttggg                                     3689


<210>  7494
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  7494

Met Gly Ile Trp Met Ala Ala Ile Gly Pro Lys Arg Tyr Gln Asp Ser 
1               5                   10                  15      


Leu Trp Leu Cys Glu Lys Thr Cys Glu Thr Gly Met Leu Ser Ser Pro 
            20                  25                  30          


Gln Tyr Ser Pro Trp Glu Leu Thr Glu Leu Trp Lys Leu Lys Glu Arg 
        35                  40                  45              


Cys Gly Asp Pro Cys Arg Cys Gln Ala Arg 
    50                  55              


<210>  7495
<211>  3304
<212>  DNA
<213>  Homosapiens

<400>  7495
gtagaaaggt ggtttatgat gggagtggct atggttttgt ctttacaaat aaaatagcat     60

taaaattttt acatttaaac tttatgggcc atgtataggg tgaagatgta agcatgggca    120

tctggatggc tgccatagga cctaaaagat accaggacag tctgtggctg tgtgagaaga    180

cctgtgagac aggaatgctg tcttctcctc agtattctcc gtgggaactg acggaactgt    240

ggaaactgaa ggaacggtgc ggtgatcctt gtcgatgtca agcaagataa cagggacttg    300

aattagcaga gtctaaaatc agggcaggca aacgataatc tgagtgcaag tctgaggagt    360

cccagggttt agcagtagac tgtatggtct ttcaagagag ttccagactg gcactttcac    420

ccagaaccaa tgcggtgttt cttaatgttt gcacaaattt ccttaaaaat caacttgtac    480

tgtagcataa gaaaagtttt tatttatcta ttggaagatt atcagaaaaa taccaagtta    540

ttttataaaa gaaaaaatat ttctaaatcc tgatgcattg tggctaatta gtaattcacc    600

attacctata gtttttggtt aaaacttggc ctagttcaga aatctgtagt agtaactgag    660

agtttgaatt tcaacctgga ttgcaggata gctctgtaga gctaattagg ataattatca    720

gacaaaaagg aactcacagg aatgctgtgt gatcatgtga tcacatattt gagcagtggt    780

cacttatacc aaagtttggg gtttctggaa ataatgtcag attttgtgga tctctgaagt    840

gggcaacttg aactaacttg aagaggaacc aatatgattc tcagttctga accttggttt    900

taaagaagtt catttatatg gtagactaat acccaaattt tctttctgcc atctaacata    960

aatcctgaag gtcacagttt agtactcata gtttttaaat gctaaagttg tgtgagtatg   1020

aataaaagca aatacctctc agggttttag tgccatcggg aaggatattt ctaaattttg   1080

ttgacatttt gaaagaatta gttttgcttt cctcctatca ttgcctaatg tttacctaat   1140

atgagtacat ttcaatcaaa gctggttatc acagaagaag atatactcag cttaggtata   1200

attgtaggga aaagcatgtg attaatttaa gtactcttag aaatagtgca actgagaaga   1260

cagataatag catattgtta tacatagtag aggatgtctc cccaagttta agggacattt   1320

cccaaaatga ccaaccaaat catttctagt aaccctttaa aatagtagtt tcaatagaga   1380

attccattaa aactagtctt atgacagata ttaactgtgt tcagatttta ttaggctagc   1440

tagtttcttt ctatttaata tttaaatctt atcatgaaat gcagtgatga gctgtaaaaa   1500

taaatatgaa ataagatcag aaaatcatta gtaggttcaa agcctttatt attgctatta   1560

tgtataagcc tagaaatggt cacttcccaa caaaaaatac atcccttgtt atacttagga   1620

caagttgtaa accccctttg ttttgacagt agaattgttc cagtgaatca tttatttccg   1680

gtgaacccca gacacgataa gcagtgtggt ctttaaattt tattagttgg ttgtcaccat   1740

cgcactaata gacaatctcc attttccaca gaataaaact gtaatgactt taggtcattt   1800

tccagctcga tttctctgcc cggcttctaa aattagaacg aaggtgggga aggatgtgat   1860

taagacagat ccgataaagc atgctacaca tactcttccc ccaccccgtc cccaggcagt   1920

agcttaccct taaaatcaaa caaacagacc catggtctcc atttagaatc aaactgttgc   1980

tatctagaga cagtttaatg tcataatacg aggactaagc ttgactttga ctttgtattt   2040

tgctgggcaa cttactttgg gactttcata ggacaacaga aggtctgaca caggaacttt   2100

gagaagacgt gacagcaatc ccttcacctt ttgaattgtc atggagccta tcaaaagaca   2160

agaaaagtcc attcgttctc tcaaatgaca gttacctgta aaactagctc atgtgatgag   2220

accacagtat cattgcaatg atagctgtat ctgtcttttt tttttttttt tttttgagac   2280

tgacttactt acttacttaa gtaagtcttg ctctgtcgcc caggctggag tgcaatggtg   2340

taatctcggc tcactgcaac ctccgcttcc cgggttcaaa caattctcct gcctcagcct   2400

cctgagtagc tggtgcccat caccacaccc agctaacttt tgtattttta gtagagacgg   2460

ggtttcacca tgttggccag gctggtcttg aactcctgac ctcgtgatcc gcccgccctg   2520

gccccccaaa gtgctgggat tacaagcatg agcccagcgc ctggctgtat ctttcatttt   2580

acccaagtca ctttacccaa gtaagtaatt aggggaaagc ctgagtcttg taccacctgt   2640

tcatttgggg aactgtggga aacggagcca acggacctaa gtgccctttg acagtgagtt   2700

tcataccatt tcagtagtgt atttctttct taatctgaat aaaccagaat gatactctca   2760

gcacagaaga ataaagggag cgagtcatta acgttttctt tttaaacctt tatgatgact   2820

tccttatgaa ttactgaacg aacactggaa tgggactcag gtatcctgag gacatctctc   2880

aactctggcc ttagttcccc ctctgtaaaa ttagggtgcc aactaaatga tctacaaggt   2940

cccttccagc gccgccattc tgtaattaca tcatgtgtaa ctgtattaaa catacacaag   3000

tgactgccag gcatgggaat gtaacttccg agtaaatgct ttggtttgtt cagaatacac   3060

tatgaacttc tttccaaaga cgggttgtgg taaatagtgg atattttgat tataagaaat   3120

agagtttcct tgaagcttta gctggagata cagcaatagt gtggtgttcc tacaaatatc   3180

acagtgtatt caaacatatt tttctatcaa aaatcatttt tgtaaaagct gtgtgttttt   3240

atccaacttg tgataataaa tgttctttat tttagaataa aaactggcct ttttgtatgt   3300

attg                                                                3304


<210>  7496
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  7496

Met Gly Ile Trp Met Ala Ala Ile Gly Pro Lys Arg Tyr Gln Asp Ser 
1               5                   10                  15      


Leu Trp Leu Cys Glu Lys Thr Cys Glu Thr Gly Met Leu Ser Ser Pro 
            20                  25                  30          


Gln Tyr Ser Pro Trp Glu Leu Thr Glu Leu Trp Lys Leu Lys Glu Arg 
        35                  40                  45              


Cys Gly Asp Pro Cys Arg Cys Gln Ala Arg 
    50                  55              


<210>  7497
<211>  572
<212>  DNA
<213>  Homosapiens

<400>  7497
gtagaaaggt ggtttatgat gggagtggct atggttttgt ctttacaaat aaaatagcat     60

taaaattttt acatttaaac tttatgggcc atgtataggg tgaagatgta agcatgggca    120

tctggatggc tgccatagga cctaaaagat accaggacag tctgtggctg tgtgagaaga    180

cctgtgagac aggaatgctg tcttctcctc agtattctcc gtgggaactg acggaactgt    240

ggaaactgaa ggaacggtgc ggtgatcctt gtcgatgtca agcaagataa cagggacttg    300

aattagcaga gtctaaaatc agggcaggca aacgataatc tgagtgcaag tctgaggagt    360

cccagggttt agcagtagac tgtatggtct ttcaagagag ttccagactg gcactttcac    420

ccagaaccaa tgcggtgttt cttaatgttt gcacaaattt ccttaaaaat caacttgtac    480

tgtagcataa gaaaagtttt tatttatcta ttggaagatt atcagaaaaa taccaagtta    540

ttttataaaa gaaaaaatat ttctaaatcc tg                                  572


<210>  7498
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  7498

Met Gly Ile Trp Met Ala Ala Ile Gly Pro Lys Arg Tyr Gln Asp Ser 
1               5                   10                  15      


Leu Trp Leu Cys Glu Lys Thr Cys Glu Thr Gly Met Leu Ser Ser Pro 
            20                  25                  30          


Gln Tyr Ser Pro Trp Glu Leu Thr Glu Leu Trp Lys Leu Lys Glu Arg 
        35                  40                  45              


Cys Gly Asp Pro Cys Arg Cys Gln Ala Arg 
    50                  55              


<210>  7499
<211>  2017
<212>  DNA
<213>  Homosapiens

<400>  7499
gccaggcgga gggggcgggg cttcggccgg ctaagccgcg gccacccgcg gtctgaggga     60

ccggaggagc ggggccggga gctgcgagga gccctccaga cgtcgccgag cgcgagggcg    120

ggcgtgctcg gagtggtcgc tcgtcagccg ccgcccctca gtctccgcac ttgcaggtcc    180

cctccctctc cgccgggacg cgggagagcc cggctcgcgg cgggggcggc caatgcgaaa    240

ctggctggtg ctgctgtgcc cgtgtgtgct cggggccgcg ctgcacctct ggctgcggct    300

gcgctccccg ccgcccgcct gcgcctccgg ggccggccct gcagatcagt tggccttatt    360

tcctcagtgg aaatctactc actatgatgt ggtagttggc gtgttgtcag ctcgcaataa    420

ccatgaactt cgaaacgtga taagaagcac ctggatgaga catttgctac agcatcccac    480

attaagtcaa cgtgtgcttg tgaagttcat aataggtgct catggctgtg aagtgcctgt    540

ggaagacagg gaagatcctt attcctgtaa actactcaac atcacaaatc cagttttgaa    600

tcaggaaatt gaagcgttca gtctgtccga agacacttca tcggggctgc ctgaggatcg    660

agttgtcagc gtgagtttcc gagttctcta ccccatcgtt attaccagtc ttggagtgtt    720

ctacgatgcc aatgatgtgg gtttccagag gaacatcact gtcaaacttt atcaggcaga    780

acaagaggag gccctcttca ttgctcgctt cagtcctcca agctgtggtg tgcaggtgaa    840

caagctgtgg tacaagcccg tggaacaatt catcttacca gagagctttg aaggtacaat    900

cgtgtgggag agccaagacc tccacggcct tgtgtcaaga aatctccaca aagtgacagt    960

gaatgatgga gggggagttc tcagagtcat tacagctggg gagggtgcat tgcctcatga   1020

attcttggaa ggtgtggagg gagttgcagg tggttttata tatactattc aggaaggtga   1080

tgctctctta cacaaccttc attctcgccc tcaaagactt attgatcata taaggaatct   1140

ccatgaggaa gatgccttac tgaaggagga aagcagcatc tatgatgata ttgtttttgt   1200

ggatgttgtc gacacttatc gtaatgttcc tgcaaaatta ttgaacttct atagatggac   1260

tgtggaaaca acgagcttca atttgttgct gaagacagat gatgactgtt acatagacct   1320

cgaagctgta tttaatagga ttgtccaaaa gaatctggat gggcctaatt tttggtgggg   1380

aaatttcaga ctgaattggg cagttgaccg aaccggaaag tggcaggagt tggagtaccc   1440

gagccccgct taccctgcct ttgcatgtgg gtcaggatat gtgatctcca aggacatcgt   1500

caagtggctg gcaagcaact cggggaggtt aaagacctat cagggtgaag atgtaagcat   1560

gggcatctgg atggctgcca taggacctaa aagataccag gacagtctgt ggctgtgtga   1620

gaagacctgt gagacaggaa tgctgtcttc tcctcagtat tctccgtggg aactgacgga   1680

actgtggaaa ctgaaggaac ggtgcggtga tccttgtcga tgtcaagcaa gataacaggg   1740

acttgaatta gcagagtcta aaatcagggc aggcaaacga taatctgagt gcaagtctga   1800

ggagtcccag ggtttagcag tagactgtat ggtctttcaa gagagttcca gactggcact   1860

ttcacccaga accaatgcgg tgtttcttaa tgtttgcaca aatttcctta aaaatcaact   1920

tgtactgtag cataagaaaa gtttttattt atctattgga agattatcag aaaaatacca   1980

agttatttta taaaagaaaa aatatttcta aatcctg                            2017


<210>  7500
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  7500

Met Arg Asn Trp Leu Val Leu Leu Cys Pro Cys Val Leu Gly Ala Ala 
1               5                   10                  15      


Leu His Leu Trp Leu Arg Leu Arg Ser Pro Pro Pro Ala Cys Ala Ser 
            20                  25                  30          


Gly Ala Gly Pro Ala Asp Gln Leu Ala Leu Phe Pro Gln Trp Lys Ser 
        35                  40                  45              


Thr His Tyr Asp Val Val Val Gly Val Leu Ser Ala Arg Asn Asn His 
    50                  55                  60                  


Glu Leu Arg Asn Val Ile Arg Ser Thr Trp Met Arg His Leu Leu Gln 
65                  70                  75                  80  


His Pro Thr Leu Ser Gln Arg Val Leu Val Lys Phe Ile Ile Gly Ala 
                85                  90                  95      


His Gly Cys Glu Val Pro Val Glu Asp Arg Glu Asp Pro Tyr Ser Cys 
            100                 105                 110         


Lys Leu Leu Asn Ile Thr Asn Pro Val Leu Asn Gln Glu Ile Glu Ala 
        115                 120                 125             


Phe Ser Leu Ser Glu Asp Thr Ser Ser Gly Leu Pro Glu Asp Arg Val 
    130                 135                 140                 


Val Ser Val Ser Phe Arg Val Leu Tyr Pro Ile Val Ile Thr Ser Leu 
145                 150                 155                 160 


Gly Val Phe Tyr Asp Ala Asn Asp Val Gly Phe Gln Arg Asn Ile Thr 
                165                 170                 175     


Val Lys Leu Tyr Gln Ala Glu Gln Glu Glu Ala Leu Phe Ile Ala Arg 
            180                 185                 190         


Phe Ser Pro Pro Ser Cys Gly Val Gln Val Asn Lys Leu Trp Tyr Lys 
        195                 200                 205             


Pro Val Glu Gln Phe Ile Leu Pro Glu Ser Phe Glu Gly Thr Ile Val 
    210                 215                 220                 


Trp Glu Ser Gln Asp Leu His Gly Leu Val Ser Arg Asn Leu His Lys 
225                 230                 235                 240 


Val Thr Val Asn Asp Gly Gly Gly Val Leu Arg Val Ile Thr Ala Gly 
                245                 250                 255     


Glu Gly Ala Leu Pro His Glu Phe Leu Glu Gly Val Glu Gly Val Ala 
            260                 265                 270         


Gly Gly Phe Ile Tyr Thr Ile Gln Glu Gly Asp Ala Leu Leu His Asn 
        275                 280                 285             


Leu His Ser Arg Pro Gln Arg Leu Ile Asp His Ile Arg Asn Leu His 
    290                 295                 300                 


Glu Glu Asp Ala Leu Leu Lys Glu Glu Ser Ser Ile Tyr Asp Asp Ile 
305                 310                 315                 320 


Val Phe Val Asp Val Val Asp Thr Tyr Arg Asn Val Pro Ala Lys Leu 
                325                 330                 335     


Leu Asn Phe Tyr Arg Trp Thr Val Glu Thr Thr Ser Phe Asn Leu Leu 
            340                 345                 350         


Leu Lys Thr Asp Asp Asp Cys Tyr Ile Asp Leu Glu Ala Val Phe Asn 
        355                 360                 365             


Arg Ile Val Gln Lys Asn Leu Asp Gly Pro Asn Phe Trp Trp Gly Asn 
    370                 375                 380                 


Phe Arg Leu Asn Trp Ala Val Asp Arg Thr Gly Lys Trp Gln Glu Leu 
385                 390                 395                 400 


Glu Tyr Pro Ser Pro Ala Tyr Pro Ala Phe Ala Cys Gly Ser Gly Tyr 
                405                 410                 415     


Val Ile Ser Lys Asp Ile Val Lys Trp Leu Ala Ser Asn Ser Gly Arg 
            420                 425                 430         


Leu Lys Thr Tyr Gln Gly Glu Asp Val Ser Met Gly Ile Trp Met Ala 
        435                 440                 445             


Ala Ile Gly Pro Lys Arg Tyr Gln Asp Ser Leu Trp Leu Cys Glu Lys 
    450                 455                 460                 


Thr Cys Glu Thr Gly Met Leu Ser Ser Pro Gln Tyr Ser Pro Trp Glu 
465                 470                 475                 480 


Leu Thr Glu Leu Trp Lys Leu Lys Glu Arg Cys Gly Asp Pro Cys Arg 
                485                 490                 495     


Cys Gln Ala Arg 
            500 


<210>  7501
<211>  3092
<212>  DNA
<213>  Homosapiens

<400>  7501
ggaggagcgg ggccgggagc tgcgaggagc cctccagacg tcgccgagcg cgagggcggg     60

cgtgctcgga gtggtcgctc gtcagccgcc gcccctcagt ctccgcactt gcaggtcccc    120

tccctctccg ccgggacgcg ggagagcccg gctcgcggcg ggggcggcca atgcgaaact    180

ggctggtgct gctgtgcccg tgtgtgctcg gggccgcgct gcacctctgg ctgcggctgc    240

gctccccgcc gcccgcctgc gcctccgggg ccggccctgc agatcagttg gccttatttc    300

ctcagtggaa atctactcac tatgatgtgg tagttggcgt gttgtcagct cgcaataacc    360

atgaacttcg aaacgtgata agaagcacct ggatgagaca tttgctacag catcccacat    420

taagtcaacg ttttgaatca ggaaattgaa gcgttcagtc tgtccgaaga cacttcatcg    480

gggctgcctg aggatcgagt tgtcagcgtg agtttccgag ttctctaccc catcgttatt    540

accagtcttg gagtgttcta cgatgccaat gatgtgggtt tccagaggaa catcactgtc    600

aaactttatc aggcagaaca agaggaggcc ctcttcattg ctcgcttcag tcctccaagc    660

tgtggtgtgc aggtgaacaa gctgtggtac aagcccgtgg aacaattcat cttaccagag    720

agctttgaag gtacaatcgt gtgggagagc caagacctcc acggccttgt gtcaagaaat    780

ctccacaaag tgacagtgaa tgatggaggg ggagttctca gagtcattac agctggggag    840

ggtgcattgc ctcatgaatt cttggaaggt gtggagggag ttgcaggtgg ttttatatat    900

actattcagg gtaagtttgc tagttgaaac ttgaaaagta cactgaatgt cttacactta    960

atctttatac ttgagagaaa aggatttttt cttttttgtc ttttaaaaaa ctttattcag   1020

ataaaattca cccttttaaa gtggttcagt ggttttagtg tattcttaga gttctacaac   1080

cggctccacc tcccaaaagg aaaccccaca cccattagca gttactcctc attcttacct   1140

ccccaacccc ccacccccta acaactactg atgcactttc tttctctatg gatttgcctg   1200

ttttgaacat ttcacataaa tggaaatgca cagtacgtac tctgtgtgtc agtttctttg   1260

ctgtaacatg tgttccaggt ctgtccattt tgtatgtatc agtacttctt ttttatgatc   1320

atataatatt ctattgcatc gatatgccct attttattca ttcattaatg gatggacatt   1380

tagattgctt ctactttttg aatatgaata attctgtagt aaacatgtag gtacaagttt   1440

ttgtgtggtc atatatttcc atttctctta aatgtctagg agtagaagac ctgggtcata   1500

taattgtgtg tttaatcact tgaggcactg ccaggttgtt ttctaaagca gcagcccact   1560

ttacatttcc atagtcagta tatgaggatt ctagtttctc catattcttg tcaacactta   1620

ataaattgtc tgtcttttaa aatataccaa tcctagtggg tgtaaattgt tatttcattg   1680

tgatttttat tcgtatttcc ataataacta atgatgttga gcattttctt catgtgctta   1740

ttggccattt gtatatcttc cttttttgtt tcgttgtttt tctttttttc tgagacgagg   1800

cctcactctg ttgcccaggc tggagtgcag tggcatgatc acagctcact gtagccttga   1860

cctccccggg ctcaagtgaa cttcccattt cagcctcccg aatagctggg actacaagtg   1920

catgccacca tgcccagcta attattaaat gttttgtaga gacagggttt tgtcatattg   1980

ctgaggctgc acactgttaa cagggtgaat tattatggta tatgagctag atgtgggaag   2040

tgagggaggg aggaggggga ggaagtgagg gaggaagggg tggagagagg gagaaggtgg   2100

tgagggaggg aggggtggag ggaagaaggg aggaaaggag gggagagaga gtcatttgta   2160

tatctttaga gaaatatcta ttcagatcct ttgcccattt ataaaattat tttgttattg   2220

ttgaattgta agagttcttt atatatgctg gatacaagtc ccttatcaga tacatgcttt   2280

gcaaatggtg ccctttaaca cacaaaagtt gtaaattttg atgaagtcca attttgtcac   2340

atgtttttgc tgtcatatgt aaggaactat tgtctaatgt gaggtcacaa agatttgtgc   2400

ctttgtttta cagttccaag agttttatag ttttagcact tatacgtagg tcttggatcc   2460

atgttcattt tcatatatgg catgaaatag aggtttaact tcattctttt gcatgtggat   2520

atccagttgt cccagcaccc atttgttgaa aatcagtgac tgtagatgta aggatttact   2580

tgaggactct caattctatt ccattgatct atgtgtctgc gtctttaacc agtactacac   2640

tgtcttgatt atgtagcttt ttagtaagat ttgaaattgg gaggctgggc acggtggctc   2700

actcctgtaa tcccagcact ttgggagccc gaggcaggtg gatcacgagg tcaggagttc   2760

gagaccagcc tgaccaacat ggtgaaaccc tgtctctact aaaaatacaa aaaaattagc   2820

caggcatggt gtcgggcgcc tgtaatccca gctactccag aggctgaggc agaagaatcg   2880

cttgaacctg ggaggcagag gttgcattga gctgagattg ccactgcatt tcatcctggg   2940

tgacagcaag actccgtctc aaaaaaaaaa aaaaaaaaaa aagaaattag gaaatgtgaa   3000

tcctccaacc ttgttctttt tcaagcttga ttggctattc tgggtctctt gcacttccat   3060

atgaatttta tgatcagctt gttaatttgt gc                                 3092


<210>  7502
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  7502

Met Arg Asn Trp Leu Val Leu Leu Cys Pro Cys Val Leu Gly Ala Ala 
1               5                   10                  15      


Leu His Leu Trp Leu Arg Leu Arg Ser Pro Pro Pro Ala Cys Ala Ser 
            20                  25                  30          


Gly Ala Gly Pro Ala Asp Gln Leu Ala Leu Phe Pro Gln Trp Lys Ser 
        35                  40                  45              


Thr His Tyr Asp Val Val Val Gly Val Leu Ser Ala Arg Asn Asn His 
    50                  55                  60                  


Glu Leu Arg Asn Val Ile Arg Ser Thr Trp Met Arg His Leu Leu Gln 
65                  70                  75                  80  


His Pro Thr Leu Ser Gln Arg Phe Glu Ser Gly Asn 
                85                  90          


<210>  7503
<211>  1872
<212>  DNA
<213>  Homosapiens

<400>  7503
ggaggagcgg ggccgggagc tgcgaggagc cctccagacg tcgccgagcg cgagggcggg     60

cgtgctcgga gtggtcgctc gtcagccgcc gcccctcagt ctccgcactt gcaggtcccc    120

tccctctccg ccgggacgcg ggagagcccg gctcgcggcg ggggcggcca atgcgaaact    180

ggctggtgct gctgtgcccg tgtgtgctcg gggccgcgct gcacctctgg ctgcggctgc    240

gctccccgcc gcccgcctgc gcctccgggg ccggccctgc aggtggagtc tcactcttgt    300

tgcccaggct ggagtgcaat ggcgcggtct cggctcaccc caacctccac ctcccgggtt    360

caagagattc tcctgcctca gcctcccaag tagctgggat aacagatcag ttggccttat    420

ttcctcagtg gaaatctact cactatgatg tggtagttgg cgtgttgtca gctcgcaata    480

accatgaact tcgaaacgtg ataagaagca cctggatgag acatttgcta cagcatccca    540

cattaagtca acgtgtgctt gtgaagttca taataggtgc tcatggctgt gaagtgcctg    600

tggaagacag ggaagatcct tattcctgta aactactcaa catcacaaat ccagttttga    660

atcaggaaat tgaagcgttc agtctgtccg aagacacttc atcggggctg cctgaggatc    720

gagttgtcag cgtgagtttc cgagttctct accccatcgt tattaccagt cttggagtgt    780

tctacgatgc caatgatgtg ggtttccaga ggaacatcac tgtcaaactt tatcaggcag    840

aacaagagga ggccctcttc attgctcgct tcagtcctcc aagctgtggt gtgcaggtga    900

acaagctgtg gtacaagccc gtggaacaat tcatcttacc agagagcttt gaaggtacaa    960

tcgtgtggga gagccaagac ctccacggcc ttgtgtcaag aaatctccac aaagtgacag   1020

tgaatgatgg agggggagtt ctcagagtca ttacagctgg ggagggtgca ttgcctcatg   1080

aattcttgga aggtgtggag ggagttgcag gtggttttat atatactatt cagggtaagt   1140

ttgctagttg aaacttgaaa agtacactga atgtcttaca cttaatcttt atacttgaga   1200

gaaaaggatt ttttcttttt tgtcttttaa aaaactttat tcagataaaa ttcacccttt   1260

taaagtggtt cagtggtttt agtgtattct tagagttcta caaccggctc cacctcccaa   1320

aaggaaaccc cacacccatt agcagttact cctcattctt acctccccaa ccccccaccc   1380

cctaacaact actgatgcac tttctttctc tatggatttg cctgttttga acatttcaca   1440

taaatggaaa tgcacagtac gtactctgtg tgtcagtttc tttgctgtaa catgtgttcc   1500

aggtctgtcc attttgtatg tatcagtact tcttttttat gatcatataa tattctattg   1560

catcgatatg ccctatttta ttcattcatt aatggatgga catttagatt gcttctactt   1620

tttgaatatg aataattctg tagtaaacat gtaggtacaa gtttttgtgt ggtcatatat   1680

ttccatttct cttaaatgtc taggagtaga agacctgggt catataattg tgtgtttaat   1740

cacttgaggc actgccaggt tgttttctaa agcagcagcc cactttacat ttccatagtc   1800

agtatatgag gattctagtt tctccatatt cttgtcaaca cttaataaat tgtctgtctt   1860

ttaaaatata cc                                                       1872


<210>  7504
<211>  326
<212>  PRT
<213>  Homosapiens

<400>  7504

Met Arg Asn Trp Leu Val Leu Leu Cys Pro Cys Val Leu Gly Ala Ala 
1               5                   10                  15      


Leu His Leu Trp Leu Arg Leu Arg Ser Pro Pro Pro Ala Cys Ala Ser 
            20                  25                  30          


Gly Ala Gly Pro Ala Gly Gly Val Ser Leu Leu Leu Pro Arg Leu Glu 
        35                  40                  45              


Cys Asn Gly Ala Val Ser Ala His Pro Asn Leu His Leu Pro Gly Ser 
    50                  55                  60                  


Arg Asp Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Ile Thr Asp Gln 
65                  70                  75                  80  


Leu Ala Leu Phe Pro Gln Trp Lys Ser Thr His Tyr Asp Val Val Val 
                85                  90                  95      


Gly Val Leu Ser Ala Arg Asn Asn His Glu Leu Arg Asn Val Ile Arg 
            100                 105                 110         


Ser Thr Trp Met Arg His Leu Leu Gln His Pro Thr Leu Ser Gln Arg 
        115                 120                 125             


Val Leu Val Lys Phe Ile Ile Gly Ala His Gly Cys Glu Val Pro Val 
    130                 135                 140                 


Glu Asp Arg Glu Asp Pro Tyr Ser Cys Lys Leu Leu Asn Ile Thr Asn 
145                 150                 155                 160 


Pro Val Leu Asn Gln Glu Ile Glu Ala Phe Ser Leu Ser Glu Asp Thr 
                165                 170                 175     


Ser Ser Gly Leu Pro Glu Asp Arg Val Val Ser Val Ser Phe Arg Val 
            180                 185                 190         


Leu Tyr Pro Ile Val Ile Thr Ser Leu Gly Val Phe Tyr Asp Ala Asn 
        195                 200                 205             


Asp Val Gly Phe Gln Arg Asn Ile Thr Val Lys Leu Tyr Gln Ala Glu 
    210                 215                 220                 


Gln Glu Glu Ala Leu Phe Ile Ala Arg Phe Ser Pro Pro Ser Cys Gly 
225                 230                 235                 240 


Val Gln Val Asn Lys Leu Trp Tyr Lys Pro Val Glu Gln Phe Ile Leu 
                245                 250                 255     


Pro Glu Ser Phe Glu Gly Thr Ile Val Trp Glu Ser Gln Asp Leu His 
            260                 265                 270         


Gly Leu Val Ser Arg Asn Leu His Lys Val Thr Val Asn Asp Gly Gly 
        275                 280                 285             


Gly Val Leu Arg Val Ile Thr Ala Gly Glu Gly Ala Leu Pro His Glu 
    290                 295                 300                 


Phe Leu Glu Gly Val Glu Gly Val Ala Gly Gly Phe Ile Tyr Thr Ile 
305                 310                 315                 320 


Gln Gly Lys Phe Ala Ser 
                325     


<210>  7505
<211>  1322
<212>  DNA
<213>  Homosapiens

<400>  7505
ctttctaggc tgttttagtc taggccgagt acattcctga actcagtgct ctggaaccac     60

aatcggggtc agtttcctag acatctctgg gattcacttt agatcacctg tagagttcat    120

cccgcagcat ctcagctggg ttaaggtgtg gaggctagac aactgaccgg ccctggtgac    180

taaccaagaa actttttcct acccattctg tggtgtgcca ttcacaatgt gttcagcaat    240

aggaaccaca catttttgta acatactatg ggtctttgga attgagtaca agtagttgaa    300

actatatgtt aattctgtca gtgtcaaagg gatctccttt tcatttgtat ctgaacttcc    360

attttaaaaa cttctgaata cgctactctc agcatactgc ttataggata gcctgctccg    420

caaaagcagt caaaaaataa attaaaaaaa acaaaacgac ttttaaataa aagccaaact    480

aaaacagggg tggaaaaaaa ggaaaatgca gatatgctaa aggaaaacaa cactactaga    540

atctcatatt tggagataat cacatttaac atttttgctt ctatgtgtta tagttgctag    600

gattatgccg ttcattctac tttataattt acttacttta acatatcacg aacatctttt    660

gatgtgctct attatttgta atggctatat agaattacat tgtatgaaag tattgtcatt    720

taactctgta tttgggtgtt gatagagttt caatttttcg gtgttatgga aaagactgta    780

gtaaatatca ctgcacctct gttttatgtg tataactggt tattttctta ggatgaattt    840

gctgggatta caggcatgag ccactgcgcc tggccaccag gtctagttat taagagtttt    900

aatgactata gccttgtgct ttttatctcc cttcaggctt taggctaaat agacttgatt    960

ttattacctt tattaatttt gtataatatt ttttctttta aaaaacaagc aggccacgtg   1020

tggtgtctca ggcttatcct cccagcactt tgggaggccg aggcgggcag atcattgagc   1080

ccatgagttt gagacgacca gcctgggcaa cttgatgaaa cccagtccct attcaaacaa   1140

caaaaataac cacacacaca aaaagcaagc aattatttaa tagtggctat acctggtggg   1200

gagctaagat tatggatgat tttaattttc ttctttttgt atatctatct tctaaatgtt   1260

ccataataaa catatattag ctttatataa tagaaagaaa aaataaactt ttagcaatta   1320

aa                                                                  1322


<210>  7506
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  7506

Met Pro Phe Ile Leu Leu Tyr Asn Leu Leu Thr Leu Thr Tyr His Glu 
1               5                   10                  15      


His Leu Leu Met Cys Ser Ile Ile Cys Asn Gly Tyr Ile Glu Leu His 
            20                  25                  30          


Cys Met Lys Val Leu Ser Phe Asn Ser Val Phe Gly Cys 
        35                  40                  45  


<210>  7507
<211>  2177
<212>  DNA
<213>  Homosapiens

<400>  7507
accggaggag cggggccggg agctgcgagg agccctccag acgtcgccga gcgcgagggc     60

gggcgtgctc ggagtggtcg ctcgtcagcc gccgcccctc agtctccgca cttgcaggtc    120

ccctccctct ccgccgggac gcgggagagc ccggctcgcg gcgggggcgg ccaatgcgaa    180

actggctggt gctgctgtgc ccgtgtgtgc tcggggccgc gctgcacctc tggctgcggc    240

tgcgctcccc gccgcccgcc tgcgcctccg gggccggccc tgcagatcag ttggccttat    300

ttcctcagtg gaaatctact cactatgatg tggtagttgg cgtgttgtca gctcgcaata    360

accatgaact tcgaaacgtg ataagaagca cctggatgag acatttgcta cagcatccca    420

cattaagtca acgttttgaa tcaggaaatt gaagcgttca gtctgtccga agacacttca    480

tcggggctgc ctgaggatcg agttgtcagc gtgagtttcc gagttctcta ccccatcgtt    540

attaccagtc ttggagtgtt ctacgatgcc aatgatgtgg gtttccagag gaacatcact    600

gtcaaacttt atcaggcaga acaagaggag gccctcttca ttgctcgctt cagtcctcca    660

agctgtggtg tgcaggtgaa caagctgtgg tacaagcccg tggaacaatt catcttacca    720

gaggtacagg atggcaggaa aagactgtag taccaatgca gtccttcata ggagtgggcg    780

tgtgctttca ggggcaggca cttgatattt tcttgtacca gggcagcact ccagagtgat    840

agatgaaggt accaactgtg gatgggctaa aacatagcac tctgtattca aacctcctga    900

ggacttcatg aggcctcaga ggttccaaaa ccactttttg aaaaacattg catgtttccg    960

tagtttattt agtggagtag agaactacac aactgtttta atgacaaagg atgatgttgg   1020

gtgtggattg atggaaagac cagacagaga taccatttgg gtaaaaatta aataatttgc   1080

ttatctaaag aatgaaaaga aaaaaaagtc agtgcagaca ggttaatgat agagatgggc   1140

catgtttcca agttaaataa aatttctcca aagggtgaac agttgtggat gatagcctga   1200

aaatgtacct gtcaccttct gggtccctct aggtccagtc ataactagat atgcactaaa   1260

gaatgcctcg cctgccaggt gccctcatta gtcctggagt taagccacac agtatggtcg   1320

cagagtgtga cagaatcagg atcagacata acaaattatt cattcatcag cttcagcctt   1380

tctaggctgt tttagtctag gccgagtaca ttcctgaact cagtgctctg gaaccacaat   1440

cggggtcagt ttcctagaca tctctgggat tcactttaga tcacctgtag agttcatccc   1500

gcagcatctc agctgggtta aggtgtggag gctagacaac tgaccggccc tggtgactaa   1560

ccaagaaact ttttcctacc cattctgtgg tgtgccattc acaatgtgtt cagcaatagg   1620

aaccacacat ttttgtaaca tactatgggt ctttggaatt gagtacaagt agttgaaact   1680

atatgttaat tctgtcagtg tcaaagggat ctccttttca tttgtatctg aacttccatt   1740

ttaaaaactt ctgaatacgc tactctcagc atactgctta taggatagcc tgctccgcaa   1800

aagcagtcaa aaaataaatt aaaaaaaaca aaacgacttt taaataaaag ccaaactaaa   1860

acaggggtgg aaaaaaagga aaatgcagat atgctaaagg aaaacaacac tactagaatc   1920

tcatatttgg agataatcac atttaacatt tttgcttcta tgtgttatag ttgctaggat   1980

tatgccgttc attctacttt ataatttact tactttaaca tatcacgaac atcttttgat   2040

gtgctctatt atttgtaatg gctatataga attacattgt atgaaagtat tgtcatttaa   2100

ctctgtattt gggtgttgat agagtttcaa tttttcggtg ttatggaaaa gactgtagta   2160

aatatcactg cacctct                                                  2177


<210>  7508
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  7508

Met Arg Asn Trp Leu Val Leu Leu Cys Pro Cys Val Leu Gly Ala Ala 
1               5                   10                  15      


Leu His Leu Trp Leu Arg Leu Arg Ser Pro Pro Pro Ala Cys Ala Ser 
            20                  25                  30          


Gly Ala Gly Pro Ala Asp Gln Leu Ala Leu Phe Pro Gln Trp Lys Ser 
        35                  40                  45              


Thr His Tyr Asp Val Val Val Gly Val Leu Ser Ala Arg Asn Asn His 
    50                  55                  60                  


Glu Leu Arg Asn Val Ile Arg Ser Thr Trp Met Arg His Leu Leu Gln 
65                  70                  75                  80  


His Pro Thr Leu Ser Gln Arg Phe Glu Ser Gly Asn 
                85                  90          


<210>  7509
<211>  389
<212>  DNA
<213>  Homosapiens

<400>  7509
ctcaagcatt ttttaaaaat tcctgccatt tgtgaattat atagcaaatg attacctagg     60

ttttggcatt aagcccactt cactacttct tactagtaaa acaaaggatt acatttgttc    120

agttatataa acctgttctc attacttagt tttgaatcag gaaattgaag cgttcagtct    180

gtccgaagac acttcatcgg ggctgcctga ggatcgagtt gtcagcgtga gtttccgagt    240

tctctacccc atcgttatta ccagtcttgg agtgttctac gatgccaatg atgtgggttt    300

ccagaggaac atcactgtca aactttatca ggcagaacaa gaggaggccc tcttcattgc    360

tcgcttcagt cctccaagct gtggtgtgc                                      389


<210>  7510
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  7510

Met Pro Met Met Trp Val Ser Arg Gly Thr Ser Leu Ser Asn Phe Ile 
1               5                   10                  15      


Arg Gln Asn Lys Arg Arg Pro Ser Ser Leu Leu Ala Ser Val Leu Gln 
            20                  25                  30          


Ala Val Val 
        35  


<210>  7511
<211>  1606
<212>  DNA
<213>  Homosapiens

<400>  7511
ggccctgccg gcagggcagc aagtcgggag cagctgtggg tggtgtccta caggctctgc     60

tgtggaggaa gagctgctgc cctgagtgga ggggcagtag aatgaaagag ggcatgtcta    120

ataacagcac cactagcatc tcccaagcca ggaaagctgt ggagcagcta aagatggaag    180

cctgtatgga cagggtcaag gtctcccagg cagctgcgga cctcctggcc tactgtgaag    240

ctcacgtgcg ggaagatcct ctcatcattc cagtgcctgc atcagaaaac ccctttcgcg    300

agaagaagtt cttttgtacc attctctaac tccgtgtgtg atgaaaacgc ctccttttct    360

gaccttcaaa gtcccctgta gagaccatgc atgctctaag ccttagggag tgagaccaac    420

acccatccct gcccagccaa cagtggccgg ggcttgtctt atgtttccat ctgttttctt    480

cgtggcattc aatttcattt ttttcctttt cattttcatg ttattttcat tattggcaaa    540

gaaaatcaaa atgtttatag ccaaataaca aatgtgccat gtaaaagtaa gtctggactt    600

aagagtttaa aatttttaaa catcagtttc caagtttata tcatattaat acatttcagt    660

ggataattta ttttaaaaaa aaaactatgc ctaaatatcc cttatttgca atattcagta    720

tcaaattaga gcattttgac caactgaaac atataacgtt ttcatctcct ttcctggaga    780

aagcagctgc agaggttctg tatttcctgc atttccatca tcctagtaaa aagacaacaa    840

cccacaggat tggaatggtt ttcttttgtt ttttttttgt tgttgttgtt gttttgagat    900

ggagtctcgc tctgtcaccc aggctggagt gcaatggcgt gacctcagct cactgcgacc    960

tccacctcct gggttcaagc gattctcctg cctcagcctc ctgagtagct gggatcatag   1020

gcacgcgcca ccacacccag ctaatttttt gtatttttag taaagacggg gtttcaccat   1080

gttggtcagg ctggtctcaa actcctgacc tcgtgatcca cccgcctcgg cctcccaaag   1140

cgctgggatt acaggcgtga gccaccacac ccggccgtgg aatggttttc ttagcatatc   1200

ctcctggggc cgtggcgccc cggctgtggg ccgtggtgga tgtcccttgt ttcagtggtc   1260

ctacaaaggt agatggtggg cggacaccga agtcaacttg actgtaaaag taccccatac   1320

cgttgacgcg ctgtggcaga cctgtgggtg cggtctcccc tctccaaatg ccacctcttc   1380

ctgctccctc ctcttttggc tcctactcag tagttccatt gtgggctgca gtaatataag   1440

gacctgttct ggacacagca ctgggcccgc tggggtttta gtagggcagc cccttccctg   1500

caggagtgag gcatggtgac agcagtcccc tatgtgcccc caagtcatct gagcattggt   1560

gtgcattaag gtactcaatc ttccaacaat aaataccata agtgca                  1606


<210>  7512
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  7512

Met Lys Glu Gly Met Ser Asn Asn Ser Thr Thr Ser Ile Ser Gln Ala 
1               5                   10                  15      


Arg Lys Ala Val Glu Gln Leu Lys Met Glu Ala Cys Met Asp Arg Val 
            20                  25                  30          


Lys Val Ser Gln Ala Ala Ala Asp Leu Leu Ala Tyr Cys Glu Ala His 
        35                  40                  45              


Val Arg Glu Asp Pro Leu Ile Ile Pro Val Pro Ala Ser Glu Asn Pro 
    50                  55                  60                  


Phe Arg Glu Lys Lys Phe Phe Cys Thr Ile Leu 
65                  70                  75  


<210>  7513
<211>  1959
<212>  DNA
<213>  Homosapiens

<400>  7513
gggggcgagg gtcgcagagt cgccggctct cccttcccca gtctgggccc ccacggcaca     60

gggggccgag cagaagcccc cagcgtccag ggccggggga gggtccgcct gcgcccccag    120

gcccgcgtgg tcgggccctg cagggcggga ggcgcggcgc ggggcggggc cggtgacggg    180

acgcggagac cccgcgggcg gcgggagggg cacgaggcgc gcgtttgcac ccgagcccgg    240

cccgcgcccc gatgcggagc gatgccgctc ggcctggccg ccccccgcga gcaccgcgct    300

gcagacgaag cccgcgcgtg atcccgctcc gggtgacctc aaagcagaag ctctgaattc    360

acctctcatc tgacgactga cagctgctgc caccgccagc ctctgtccct tgcccaggcc    420

tgtcacacgg ctgcctctca gcaggggcag tagaatgaaa gagggcatgt ctaataacag    480

caccactagc atctcccaag ccaggaaagc tgtggagcag ctaaagatgg aagcctgtat    540

ggacagggtc aaggtctccc aggcagctgc ggacctcctg gcctactgtg aagctcacgt    600

gcgggaagat cctctcatca ttccagtgcc tgcatcagaa aacccctttc gcgagaagaa    660

gttcttttgt accattctct aactccgtgt gtgatgaaaa cgcctccttt tctgaccttc    720

aaagtcccct gtagagacca tgcatgctct aagccttagg gagtgagacc aacacccatc    780

cctgcccagc caacagtggc cggggcttgt cttatgtttc catctgtttt cttcgtggca    840

ttcaatttca tttttttcct tttcattttc atgttatttt cattattggc aaagaaaatc    900

aaaatgttta tagccaaata acaaatgtgc catgtaaaag taagtctgga cttaagagtt    960

taaaattttt aaacatcagt ttccaagttt atatcatatt aatacatttc agtggataat   1020

ttattttaaa aaaaaaacta tgcctaaata tcccttattt gcaatattca gtatcaaatt   1080

agagcatttt gaccaactga aacatataac gttttcatct cctttcctgg agaaagcagc   1140

tgcagaggtt ctgtatttcc tgcatttcca tcatcctagt aaaaagacaa caacccacag   1200

gattggaatg gttttctttt gttttttttt tgttgttgtt gttgttttga gatggagtct   1260

cgctctgtca cccaggctgg agtgcaatgg cgtgacctca gctcactgcg acctccacct   1320

cctgggttca agcgattctc ctgcctcagc ctcctgagta gctgggatca taggcacgcg   1380

ccaccacacc cagctaattt tttgtatttt tagtaaagac ggggtttcac catgttggtc   1440

aggctggtct caaactcctg acctcgtgat ccacccgcct cggcctccca aagcgctggg   1500

attacaggcg tgagccacca cacccggccg tggaatggtt ttcttagcat atcctcctgg   1560

ggccgtggcg ccccggctgt gggccgtggt ggatgtccct tgtttcagtg gtcctacaaa   1620

ggtagatggt gggcggacac cgaagtcaac ttgactgtaa aagtacccca taccgttgac   1680

gcgctgtggc agacctgtgg gtgcggtctc ccctctccaa atgccacctc ttcctgctcc   1740

ctcctctttt ggctcctact cagtagttcc attgtgggct gcagtaatat aaggacctgt   1800

tctggacaca gcactgggcc cgctggggtt ttagtagggc agccccttcc ctgcaggagt   1860

gaggcatggt gacagcagtc ccctatgtgc ccccaagtca tctgagcatt ggtgtgcatt   1920

aaggtactca atcttccaac aataaatacc ataagtgca                          1959


<210>  7514
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  7514

Met Lys Glu Gly Met Ser Asn Asn Ser Thr Thr Ser Ile Ser Gln Ala 
1               5                   10                  15      


Arg Lys Ala Val Glu Gln Leu Lys Met Glu Ala Cys Met Asp Arg Val 
            20                  25                  30          


Lys Val Ser Gln Ala Ala Ala Asp Leu Leu Ala Tyr Cys Glu Ala His 
        35                  40                  45              


Val Arg Glu Asp Pro Leu Ile Ile Pro Val Pro Ala Ser Glu Asn Pro 
    50                  55                  60                  


Phe Arg Glu Lys Lys Phe Phe Cys Thr Ile Leu 
65                  70                  75  


<210>  7515
<211>  2005
<212>  DNA
<213>  Homosapiens

<400>  7515
cttgtggacg gcggatgagg atgaggcgcc cagatcttcc cgaaatattt cctaatcgtt     60

catcatgatg ttatgttgtt gttttcacaa agggaattaa tattggcctc cttttctaca    120

aatcttgcca acactgcgtg aaatgttttc gttgcttctc tattcccaag gtttcgtatt    180

attttaccaa gtcggaaaat ggacggcgct taaactgttt tttccctgaa aggaagaggg    240

ctgtaatcac taaagtgttt taaaatctcc agcgcaaaag cctgcggtgc cacagggacg    300

aggcctggag agcagtcgct cctagaaccg gggcgcgaag ggcacccccg cctccagcac    360

gcgccctccg ccctcccggc ctcgctcccc ccggagtggg ggcctcgccg gcccctggtc    420

cccgtcactc agcaacgtcg ggtcagcctt cgccgggtta gtggcgacgc ggccgcgcga    480

attcgcacag gggcagtaga atgaaagagg gcatgtctaa taacagcacc actagcatct    540

cccaagccag gaaagctgtg gagcagctaa agatggaagc ctgtatggac agggtcaagg    600

tctcccaggc agctgcggac ctcctggcct actgtgaagc tcacgtgcgg gaagatcctc    660

tcatcattcc agtgcctgca tcagaaaacc cctttcgcga gaagaagttc ttttgtacca    720

ttctctaact ccgtgtgtga tgaaaacgcc tccttttctg accttcaaag tcccctgtag    780

agaccatgca tgctctaagc cttagggagt gagaccaaca cccatccctg cccagccaac    840

agtggccggg gcttgtctta tgtttccatc tgttttcttc gtggcattca atttcatttt    900

tttccttttc attttcatgt tattttcatt attggcaaag aaaatcaaaa tgtttatagc    960

caaataacaa atgtgccatg taaaagtaag tctggactta agagtttaaa atttttaaac   1020

atcagtttcc aagtttatat catattaata catttcagtg gataatttat tttaaaaaaa   1080

aaactatgcc taaatatccc ttatttgcaa tattcagtat caaattagag cattttgacc   1140

aactgaaaca tataacgttt tcatctcctt tcctggagaa agcagctgca gaggttctgt   1200

atttcctgca tttccatcat cctagtaaaa agacaacaac ccacaggatt ggaatggttt   1260

tcttttgttt tttttttgtt gttgttgttg ttttgagatg gagtctcgct ctgtcaccca   1320

ggctggagtg caatggcgtg acctcagctc actgcgacct ccacctcctg ggttcaagcg   1380

attctcctgc ctcagcctcc tgagtagctg ggatcatagg cacgcgccac cacacccagc   1440

taattttttg tatttttagt aaagacgggg tttcaccatg ttggtcaggc tggtctcaaa   1500

ctcctgacct cgtgatccac ccgcctcggc ctcccaaagc gctgggatta caggcgtgag   1560

ccaccacacc cggccgtgga atggttttct tagcatatcc tcctggggcc gtggcgcccc   1620

ggctgtgggc cgtggtggat gtcccttgtt tcagtggtcc tacaaaggta gatggtgggc   1680

ggacaccgaa gtcaacttga ctgtaaaagt accccatacc gttgacgcgc tgtggcagac   1740

ctgtgggtgc ggtctcccct ctccaaatgc cacctcttcc tgctccctcc tcttttggct   1800

cctactcagt agttccattg tgggctgcag taatataagg acctgttctg gacacagcac   1860

tgggcccgct ggggttttag tagggcagcc ccttccctgc aggagtgagg catggtgaca   1920

gcagtcccct atgtgccccc aagtcatctg agcattggtg tgcattaagg tactcaatct   1980

tccaacaata aataccataa gtgca                                         2005


<210>  7516
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  7516

Met Lys Glu Gly Met Ser Asn Asn Ser Thr Thr Ser Ile Ser Gln Ala 
1               5                   10                  15      


Arg Lys Ala Val Glu Gln Leu Lys Met Glu Ala Cys Met Asp Arg Val 
            20                  25                  30          


Lys Val Ser Gln Ala Ala Ala Asp Leu Leu Ala Tyr Cys Glu Ala His 
        35                  40                  45              


Val Arg Glu Asp Pro Leu Ile Ile Pro Val Pro Ala Ser Glu Asn Pro 
    50                  55                  60                  


Phe Arg Glu Lys Lys Phe Phe Cys Thr Ile Leu 
65                  70                  75  


<210>  7517
<211>  2005
<212>  DNA
<213>  Homosapiens

<400>  7517
attacaccag ctctctcagt ccggggagga ggaggagcag gaggaacgcg aggaggaagg     60

agaggaggag cggccagcag tagccacgac cgccaccacc aggcagagga agagttcgtg    120

gggaggaaaa gacctctcct cccccttgga gcgccttctc tctgcttttg gagaaaggga    180

atacacgata aagaaggaga cggaaagaag agaaaaagtg aggcgggaga cagagggaaa    240

agggcgtgaa cagaaagggc cggagcgtgc aggggagcac agggcgcggg ggcggcactg    300

ccgagccggg agcgctgccg cttgggcagg tgccgcggcc gctgcccgga ggcggcatgt    360

gacgcgcggc cgcagctgcc cgcgggcgga gcgctctcag accccggagc gcacaccgcg    420

gggccatcgg tgccatcgcg gatctccagg ctcctcatca gtccgccggg gccgcagcag    480

cgcttctggg aagacgggcg atgaactgaa gggcggctcc gggcaggggg gcacgatctt    540

aaggacagtc gctccctgaa cgcggagccg gaggagacga agggaaggtg gagcggacgc    600

cacccgcgca ccgggcaggc gcggagaccg gcgtgggaca gccacctgga gcgcagctgc    660

cagaaagaag gactttgctg ctttgggcca ggatctgaac ttaggtgtaa accattgccc    720

tggcagaggg aacctaccca gtccattgct gcctgctaca agatatgaac agtaatggca    780

catattttgg ttatgagtca ctcagaggac tgtggattga atgaactgta tccatcccca    840

tcatgatgta cagaaccaag tctcttcact acacttgtgt tctgattagt ggccaaataa    900

atgacagtca gaacttcagc taaggtacaa taaggttttg ctgtggcgtg gcacctggtc    960

tctttctaga aggaaagttc aacatacagc acaattctgg acacattgta ttggtttgat   1020

gctcctacct ggaacagatc ctcatgagct agtaagtttg aaggggagtc ataaagagga   1080

acaggcatta tacgcaaggc tgaagaagca gttggtaact aacagtacat ctttttctaa   1140

ggccaacact aaacataagt tgcagagctg gcctgtggtg gaactcacaa gtcttattgg   1200

caatatatgt gaggagacaa aaagcaacat atggagaaat acaaaaatat actccctaga   1260

gatactgcct cttcagatgt caagaaaaac ctggatgaaa tgaagcaaga gtggcacgct   1320

gcaaagttac aaattcaagg ccacccacag aaccaaacat taacacttag gtggagctgg   1380

tctcttgggc agcctgacat ctggtccact cctctgtcct atgccgggat catcatgacc   1440

gtagagatta tgtcactgtt ttgcatcctt gttacataac tcagttcctg gtagattcca   1500

gtgaaaggca catggtggtg atatttttga gaaagtagag aagaaaagaa tgaatccgga   1560

tggttgttga gacagaaact gagcgtcgaa cctcattttc tctcgtaccc aaaccttgat   1620

gaaacaacag aggaaagtat tgggctgcaa ttgtaggcgc acaaaagcaa accttgagtc   1680

atggatgacc gaccaaggaa gagtcccctt gggaggagga ggtgccaaag accagtgata   1740

ctgctttggg ttatgtgcac tgagggtttc caaccctgac ggatatggat tctaatttaa   1800

aatatcacag ggaagaaaaa aatagacgtt cccatggcaa cattttctca gggccagctc   1860

ttctgtctta ttatcatatc ttatttaaat atttcctgga atcagtttaa acttaatccc   1920

tctgtgtgtc ttctattttc agtggccatg gagagcgtaa catctggtca gaggttttcc   1980

ttaaataaat catataattg taggc                                         2005


<210>  7518
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  7518

Met Leu Leu Pro Gly Thr Asp Pro His Glu Leu Val Ser Leu Lys Gly 
1               5                   10                  15      


Ser His Lys Glu Glu Gln Ala Leu Tyr Ala Arg Leu Lys Lys Gln Leu 
            20                  25                  30          


Val Thr Asn Ser Thr Ser Phe Ser Lys Ala Asn Thr Lys His Lys Leu 
        35                  40                  45              


Gln Ser Trp Pro Val Val Glu Leu Thr Ser Leu Ile Gly Asn Ile Cys 
    50                  55                  60                  


Glu Glu Thr Lys Ser Asn Ile Trp Arg Asn Thr Lys Ile Tyr Ser Leu 
65                  70                  75                  80  


Glu Ile Leu Pro Leu Gln Met Ser Arg Lys Thr Trp Met Lys 
                85                  90                  


<210>  7519
<211>  926
<212>  DNA
<213>  Homosapiens

<400>  7519
tggagcgcct tctctctgct tttggagaaa gggaatacac gataaagaag gagacggaaa     60

gaagagaaaa agtgaggcgg gagacagagg gaaaagggcg tgaacagaaa gggccggagc    120

gtgcagggga gcacagggcg cgggggcggc actgccgagc cgggagcgct gccgcttggg    180

caggtgccgc ggccgctgcc cggaggcggc atgtgacgcg cggccgcagc tgcccgcggg    240

cggagcgctc tcagaccccg gagcgcacac cgcggggcca tcggtgccat cgcggatctc    300

caggctcctc atcagtccgc cggggccgca gcagcgcttc tgggaagacg ggcgatgaac    360

tgaagggcgg ctccgggcag gggggcacga tcttaaggac agtcgctccc tgaacgcgga    420

gccggaggag acgaagggaa ggtggagcgg acgccacccg cgcaccgggc aggcgcggag    480

accggcgtgg gacagccacc tggagcgcag ctgccagaaa gaaggacttt gctgctttgg    540

gccaggatct gaacttaggt gtaaaccatt gccctggcag agggaaccta cccagtccat    600

tgctgcctgc tacaagatat gaacagtaat ggcacatatt ttggttatga gtcactcaga    660

ggactgtgga ttgaatgaac tgtatccatc cccatcatga tgtacagaac caagtctctt    720

cactatgtac agtgtacttg accagaggat tcatgagggg cagtattgta gtacgcagag    780

tgcggaagca gagaagagag tccagctgtt tgttcgttaa gccagatatg gaagagattt    840

gcaaaaaatg taaatcatgt cacattttac taattttgtc ttagaatatg tgttattttc    900

attaaaagat actgtttaat tatgct                                         926


<210>  7520
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  7520

Met Asn Cys Ile His Pro His His Asp Val Gln Asn Gln Val Ser Ser 
1               5                   10                  15      


Leu Cys Thr Val Tyr Leu Thr Arg Gly Phe Met Arg Gly Ser Ile Val 
            20                  25                  30          


Val Arg Arg Val Arg Lys Gln Arg Arg Glu Ser Ser Cys Leu Phe Val 
        35                  40                  45              


Lys Pro Asp Met Glu Glu Ile Cys Lys Lys Cys Lys Ser Cys His Ile 
    50                  55                  60                  


Leu Leu Ile Leu Ser 
65                  


<210>  7521
<211>  1923
<212>  DNA
<213>  Homosapiens

<400>  7521
gggcaatggc gggcgcccct cccccagcct cgttgccgcc ttgcagtttg atctcagact     60

gctgtgctag caatcagcga gactccgtgg gcgtaggacc ctccgagcca ggtgtgggat    120

atagtctcgt ggtgcgccgt ttcttaagct ggtctgaaaa gcgcaatatt cgggtgggag    180

tgacccgatt ttccaggtgc ttccgtcacc cctttctttg actcggaaag ggaactccct    240

gaccccttgc gcttcccagg tgaggcaatg cctcgccctg cttcggctcg cgcacggtgc    300

gcgcacacac tggcctgcgc ccactgtcta gcactcccta gtgagatgaa cccggtacct    360

cagatggaaa tgcagaaatc acccgtcttc tgcgtcgctc acgctgggag ctgtagaccg    420

gagctgttcc tattcggcca tcttggctcc tagtattttt aattaagcac ttgtgttctg    480

attagtggcc aaataaatga cagtcagaac ttcagctaag gtacaataag gttttgctgt    540

ggcgtggcac ctggtctctt tctagaagga aagttcaaca tacagcacaa ttctggacac    600

attgtattgg tttgatgctc ctacctggaa caggtggagc tggtctcttg ggcagcctga    660

catctggtcc actcctctgt cctatgccgg gatcatcatg accgtagaga ttatgtcact    720

gttttgcatc cttgttacat aactcagttc ctggtagatt actatgtcag agagtcacaa    780

tgaccttgca caataacagt acaacctcgc ctttgtttcc aaacatcagc tcctcctgga    840

tacacagccc ctccgatgca gggctgcccc cgggaaccgt cactcatttc ggcagctaca    900

atgtttctcg agcagctggc aatttctcct ctccagacgg taccaccgat gaccctctgg    960

gaggtcatac cgtctggcaa gtggtcttca tcgctttctt aacgggcatc ctggccttgg   1020

tgaccatcat cggcaacatc ctggtaattg tgtcatttaa ggtcaacaag cagctgaaga   1080

cggtcaacaa ctacttcctc ttaagcctgg cctgtgccga tctgattatc ggggtcattt   1140

caatgaatct gtttacgacc tacatcatca tgaatcgatg ggccttaggg aacttggcct   1200

gtgacctctg gcttgccatt gactacgtag ccagcaatgc ctctgttatg aatcttctgg   1260

tcatcagctt tgacagatac ttttccatca cgaggccgct cacgtaccga gccaaacgaa   1320

caacaaagag agccggtgtg atgatcggtc tggcttgggt catctccttt gtcctttggg   1380

ctcctgccat cttgttctgg caatactttg ttggaaagag aactgtgcct ccgggagagt   1440

gcttcattca gttcctcagt gagcccacca ttacttttgg cacagccatc gctgcttttt   1500

atatgcctgt caccattatg actattttat actggaggat ctataaggaa actgaaaagc   1560

gtaccaaaga gcttgctggc ctgcaagcct ctgggacaga ggcagagaca gaaaactttg   1620

tccaccccac gggcagttct cgaagctgca gcagttacga acttcaacag caaagcatga   1680

aacgctccaa caggaggaag tatggccgct gccacttctg gttcacaacc aagagctgga   1740

aacccagctc cgagcagatg gaccaagacc acagcagcag tgacagttgg aacaacaatg   1800

atgctgctgc ctccctggag aactccgcct cctccgacga ggaggacatt ggctccgaga   1860

cgagagccat ctactccatc gtgctcaagc ttccgggtca cagcaccatc ctcaactcca   1920

cca                                                                 1923


<210>  7522
<211>  380
<212>  PRT
<213>  Homosapiens

<400>  7522

Met Thr Leu His Asn Asn Ser Thr Thr Ser Pro Leu Phe Pro Asn Ile 
1               5                   10                  15      


Ser Ser Ser Trp Ile His Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly 
            20                  25                  30          


Thr Val Thr His Phe Gly Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn 
        35                  40                  45              


Phe Ser Ser Pro Asp Gly Thr Thr Asp Asp Pro Leu Gly Gly His Thr 
    50                  55                  60                  


Val Trp Gln Val Val Phe Ile Ala Phe Leu Thr Gly Ile Leu Ala Leu 
65                  70                  75                  80  


Val Thr Ile Ile Gly Asn Ile Leu Val Ile Val Ser Phe Lys Val Asn 
                85                  90                  95      


Lys Gln Leu Lys Thr Val Asn Asn Tyr Phe Leu Leu Ser Leu Ala Cys 
            100                 105                 110         


Ala Asp Leu Ile Ile Gly Val Ile Ser Met Asn Leu Phe Thr Thr Tyr 
        115                 120                 125             


Ile Ile Met Asn Arg Trp Ala Leu Gly Asn Leu Ala Cys Asp Leu Trp 
    130                 135                 140                 


Leu Ala Ile Asp Tyr Val Ala Ser Asn Ala Ser Val Met Asn Leu Leu 
145                 150                 155                 160 


Val Ile Ser Phe Asp Arg Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr 
                165                 170                 175     


Arg Ala Lys Arg Thr Thr Lys Arg Ala Gly Val Met Ile Gly Leu Ala 
            180                 185                 190         


Trp Val Ile Ser Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln 
        195                 200                 205             


Tyr Phe Val Gly Lys Arg Thr Val Pro Pro Gly Glu Cys Phe Ile Gln 
    210                 215                 220                 


Phe Leu Ser Glu Pro Thr Ile Thr Phe Gly Thr Ala Ile Ala Ala Phe 
225                 230                 235                 240 


Tyr Met Pro Val Thr Ile Met Thr Ile Leu Tyr Trp Arg Ile Tyr Lys 
                245                 250                 255     


Glu Thr Glu Lys Arg Thr Lys Glu Leu Ala Gly Leu Gln Ala Ser Gly 
            260                 265                 270         


Thr Glu Ala Glu Thr Glu Asn Phe Val His Pro Thr Gly Ser Ser Arg 
        275                 280                 285             


Ser Cys Ser Ser Tyr Glu Leu Gln Gln Gln Ser Met Lys Arg Ser Asn 
    290                 295                 300                 


Arg Arg Lys Tyr Gly Arg Cys His Phe Trp Phe Thr Thr Lys Ser Trp 
305                 310                 315                 320 


Lys Pro Ser Ser Glu Gln Met Asp Gln Asp His Ser Ser Ser Asp Ser 
                325                 330                 335     


Trp Asn Asn Asn Asp Ala Ala Ala Ser Leu Glu Asn Ser Ala Ser Ser 
            340                 345                 350         


Asp Glu Glu Asp Ile Gly Ser Glu Thr Arg Ala Ile Tyr Ser Ile Val 
        355                 360                 365             


Leu Lys Leu Pro Gly His Ser Thr Ile Leu Asn Ser 
    370                 375                 380 


<210>  7523
<211>  567
<212>  DNA
<213>  Homosapiens

<400>  7523
aggttttgct gtggcgtggc acctggtctc tttctagaag gaaagttcaa catacagcac     60

aattctggac acattgtatt ggtttgatgc tcctacctgg aacaggtaac agaggaagtt    120

cctaagttgt ctggagattg catgtcctca cacactaaaa tcctctgagc tgaatgattc    180

agctttcact attgctgtgt ctgtggacaa aaaagcaaaa tgtgagtcaa ttccaggttc    240

cgtcacattt gggagttgcc aagtaaagga aaacataaaa gattaatgtt attattctga    300

ttttattttg ttttgaggag aagcgtggga aatgactacc atacaaatca agaaattcat    360

gaaggcaaac agttgatgac tgtcacctag caatctgtta ttttctttta tcctttcccc    420

aagacatatg ccctctgaca taagcattaa aatcaaatta tacaattgtc agaaaacctg    480

ttctcaaagc tttagggtaa aaattgttta atcaaattgt aacacaaatt gagaaatatc    540

attaaagtga taatgccatc ctgtaag                                        567


<210>  7524
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  7524

Met Ile Gln Leu Ser Leu Leu Leu Cys Leu Trp Thr Lys Lys Gln Asn 
1               5                   10                  15      


Val Ser Gln Phe Gln Val Pro Ser His Leu Gly Val Ala Lys 
            20                  25                  30  


<210>  7525
<211>  2441
<212>  DNA
<213>  Homosapiens

<400>  7525
tttaatctat agagtgttat tctacactgg acctctctct tattttttgg agtctagcat     60

cttgcatctt cctggagccc caactaaact cataacttct aagcttctaa gaaatatatg    120

acgagctcca tgagggccaa ggctctccat tcttgttcac cactgcacac tcaggagctc    180

atggcatgct ggctgtgcta gttctatcct caacagaata attgctgaca aactctcttg    240

cccagaaaat gtctactgga attatggagt acaaaaaaac tacaaaagca atgaaaaaaa    300

gaaggatgtt ttatttacat cctatttcaa aaccattgct ttcttgctat tgtatgtctc    360

tgcaggccca atatcgcgca tcttcataag aagtttagaa ttgttcctta tgtttccttc    420

taacaaacac tggtgttaag tttcaagaag ttggtgaaat ggagacagcc aatccaaccc    480

aggagacagt gtttgaaaac agggcttcag ctacttgcat gatgtggatt ggggaaatgg    540

tctgtcctcc tagccatggg atgtccctgc tgtgttcagg aatctttcca tctcttggat    600

tttaaaggaa agttaatttt tccttcccta taaagatagg gcctttatag aggtaatcgc    660

cttaaaatga ggctattaga gtggccttaa tccaacatca ctagagttct tagaagaagg    720

ggacatttgg acacagagac atggggagaa cgccatatga agacgaaggc agagattcat    780

ctacaaacca aggaactaca aagactgcca gcagccccca gaagccaggc ggcagacatg    840

gaacagattc tccctcacag ctgtcaggag gagccaaccc tgcctccaga attgtgaagc    900

actaagtttc tgttgtttag gccttccagt ctctgctact ttattgcaac aactctagca    960

aattaatgca caaatggcag aatggtattt ttcaactttt atgagaaaag taaaggcagt   1020

tatagtagaa gagagcatca tgagtcgact gtgctcagat agggctattt gcttttcccc   1080

aactatgctc catacttttt tcttttcata tgtttttttt gagtcggggt cttgctctgc   1140

tgcccaggtt ggagtgcagt gtcatgatca tagctcactg taacctcgac cttctgagct   1200

tgagtgatcc tcctgtctca gcctcccaag tagctgagac tgcaggtgca tgccaacaca   1260

gctggctatt tatttgtttt tattttattg tagagacagg gtctcattgt gttgcccagg   1320

ctggcctcaa acttctggcc ttaagtcatc ctcctgtctt ggcctcccaa agtgctggga   1380

ctatgggtgt gaacccatcg cacccagaca ttttgtactt ctttaatttg gagtgtcttt   1440

cctttccatg catgcctata gaatttatga ttatcattta gcccaaagaa gactttcgca   1500

taaattctgc cgtaaccctt gttggaataa atgtattcct ctaagctccc tctagctcta   1560

tttgtatctt tattataaat attaatatat ctttccttgc attgctgtta catgtatgca   1620

catcttatct tctggcaata aataagcctc gtcccttggg ggaagggcta acctttcctc   1680

cttctggtat tgctcaggat gctgaccaca gcaccctgca cagagaagag gtttaatatt   1740

tattttatta cttaaattgc ataagaggga tctacctact tgtgaaaaag gttgctgtga   1800

cctgtgttcc ttcttctgtg acaagaaact aaaatgtaca tatattctct tcttgatgtt   1860

ctttcgagtt ttatctcctt cctagatctg gttcaccaga tttcctcccc tccttttttt   1920

tcatcaatac aaaacttcaa gtcgcagtct tgccaataat tcttctttga ctaatttatg   1980

agttaaataa agaaaaaatt cctcacacac atatcatgtc caaggtcagc tcaacattgc   2040

tttattccac acctctcaat gggtgtatga tgcgggccca ctttaacact gtatcagtgg   2100

ttgattccta cgtgcagatc tttctgctct ttttgcctga attatcttca atgttctttg   2160

tgcaaaaatc acagccagta tagtctattt ccaaaagagc tgtaaagagg catttcagaa   2220

acttccctaa acaatatttc tttaaaatgc accaagctgg ataaagccgc tttgtgacct   2280

gcataaaaac tccaacggat aaatgtgtat taccttccca aagaactact tctccaaagt   2340

tattccagct ctttccagtt gaaatgtcaa acttgacata aaaatgagat gttcttgcat   2400

caattaataa acaaataaat ctgtgtttcc cattgccctt t                       2441


<210>  7526
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  7526

Met Phe Phe Leu Ser Arg Gly Leu Ala Leu Leu Pro Arg Leu Glu Cys 
1               5                   10                  15      


Ser Val Met Ile Ile Ala His Cys Asn Leu Asp Leu Leu Ser Leu Ser 
            20                  25                  30          


Asp Pro Pro Val Ser Ala Ser Gln Val Ala Glu Thr Ala Gly Ala Cys 
        35                  40                  45              


Gln His Ser Trp Leu Phe Ile Cys Phe Tyr Phe Ile Val Glu Thr Gly 
    50                  55                  60                  


Ser His Cys Val Ala Gln Ala Gly Leu Lys Leu Leu Ala Leu Ser His 
65                  70                  75                  80  


Pro Pro Val Leu Ala Ser Gln Ser Ala Gly Thr Met Gly Val Asn Pro 
                85                  90                  95      


Ser His Pro Asp Ile Leu Tyr Phe Phe Asn Leu Glu Cys Leu Ser Phe 
            100                 105                 110         


Pro Cys Met Pro Ile Glu Phe Met Ile Ile Ile 
        115                 120             


<210>  7527
<211>  1332
<212>  DNA
<213>  Homosapiens

<400>  7527
gcacattcac ttactgccat ttcctgccta tgaggagtta aatggtattt ttttcttcaa     60

gaaatattcc acagtagttg tttaacatgt tagagacaga ttgaagaaag agttaaaata    120

gtattcataa atgaatttaa tctgtatcat agtctgaaag attgtttcaa ggccaaggcc    180

caatactctt ctatattaaa ttatctcaag gtatgtttat tttcaatcca tgcttaagtt    240

tagctacaga gtcagggata aagtaggata agtgaaggta tttaattatt gttttctttt    300

ccagatcctc aacagaataa ttgctgacaa actctcttgc ccagaaaatg tctactggaa    360

ttatggagta caaaaaaact acaaaagcaa tgaaaaaaag aaggatgttt tatttacatc    420

ctatttcaaa accattgctt tcttgctatt gtatgtctct gcaggcccaa tatcgcgcat    480

cttcataaga agtttagaat tgttccttat gtttccttct aacaaacact ggtatattca    540

catgaaagtg tatattttat tcacttccaa aacagttagc tcataattca gaacattgag    600

gtttgcaaaa tgactgaagg aaactttacc taaacaatag ttgccagttc tgctgagaat    660

tatcacgggc ccacaacggc tgtgtgtttt tccatacaga tattctaatt tttttattat    720

gcagctaatt tttttttaga ctcgcgaata aaatagcaag tcagtctgtg cataagcata    780

tgtttaaatc taccaggaga aatgtctgga atctttttgg ttattaaaat taaaattcag    840

gataatgaaa ggcatatgca acttattata ttctttatat aacttatttc atctaatcct    900

ccaaatagct atataacata tttatcccca ccttacatag atgttaacca aagtctgtaa    960

ggttcgttca tttgtccaca gttacccaga aaattgtttg tggagctcag tacaaggctg   1020

actgccagac tccaaagtct atgttccttc tactaccata cattgccttt gtttttcttt   1080

tataaaagtt gaaaaaatat cattctgctt ttcctacttt tccgaaaact atttatgatg   1140

ataaatccag ttttttgtgt taagtttcaa gaagttggtg aaatggagac agccaatcca   1200

acccaggaga cagtgtttga aaacagggct tcagctactt gcatgatgtg gattggggaa   1260

atggtctgtc ctcctagcca tgggatgtcc ctgctgtgtt caggaatctt tccatctctt   1320

ggattttaaa gg                                                       1332


<210>  7528
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  7528

Met Met Ile Asn Pro Val Phe Cys Val Lys Phe Gln Glu Val Gly Glu 
1               5                   10                  15      


Met Glu Thr Ala Asn Pro Thr Gln Glu Thr Val Phe Glu Asn Arg Ala 
            20                  25                  30          


Ser Ala Thr Cys Met Met Trp Ile Gly Glu Met Val Cys Pro Pro Ser 
        35                  40                  45              


His Gly Met Ser Leu Leu Cys Ser Gly Ile Phe Pro Ser Leu Gly Phe 
    50                  55                  60                  


<210>  7529
<211>  1332
<212>  DNA
<213>  Homosapiens

<400>  7529
agtacggtat tgttgcagct gacctgtata cgtaaggaat tactgggtca tcagctctgg     60

ggaatgtctt ttgattatga acacattttc agcatgtgtc cactgaaggt ggagctggtc    120

tcttgggcag cctgacatct ggtccactcc tctgtcctat gccgggatca tcatgaccgt    180

agagattatg tcactgtttt gcatccttgt tacataactc agttcctggt agattactat    240

gtcagagagt cacaatgacc ttgcacaata acagtacaac ctcgcctttg tttccaaaca    300

tcagctcctc ctggatacac agcccctccg atgcagggct gcccccggga accgtcactc    360

atttcggcag ctacaatgtt tctcgagcag ctggcaattt ctcctctcca gacggtacca    420

ccgatgaccc tctgggaggt cataccgtct ggcaagtggt cttcatcgct ttcttaacgg    480

gcatcctggc cttggtgacc atcatcggca acatcctggt aattgtgtca tttaaggtca    540

acaagcagct gaagacggtc aacaactact tcctcttaag cctggcctgt gccgatctga    600

ttatcggggt catttcaatg aatctgttta cgacctacat catcatgaat cgatgggcct    660

tagggaactt ggcctgtgac ctctggcttg ccattgacta cgtagccagc aatgcctctg    720

ttatgaatct tctggtcatc agctttgaca gatacttttc catcacgagg ccgctcacgt    780

accgagccaa acgaacaaca aagagagccg gtgtgatgat cggtctggct tgggtcatct    840

cctttgtcct ttgggctcct gccatcttgt tctggcaata ctttgttgga aagagaactg    900

tgcctccggg agagtgcttc attcagttcc tcagtgagcc caccattact tttggcacag    960

ccatcgctgc tttttatatg cctgtcacca ttatgactat tttatactgg aggatctata   1020

aggaaactga aaagcgtacc aaagagcttg ctggcctgca agcctctggg acagaggcag   1080

agacagaaaa ctttgtccac cccacgggca gttctcgaag ctgcagcagt tacgaacttc   1140

aacagcaaag catgaaacgc tccaacagga ggaagtatgg ccgctgccac ttctggttca   1200

caaccaagag ctggaaaccc agctccgagc agatggacca agaccacagc agcagtgaca   1260

gttggaacaa caatgatgct gctgcctccc tggagaactc cgcctcctcc gacgaggagg   1320

acattggctc cg                                                       1332


<210>  7530
<211>  358
<212>  PRT
<213>  Homosapiens

<400>  7530

Met Thr Leu His Asn Asn Ser Thr Thr Ser Pro Leu Phe Pro Asn Ile 
1               5                   10                  15      


Ser Ser Ser Trp Ile His Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly 
            20                  25                  30          


Thr Val Thr His Phe Gly Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn 
        35                  40                  45              


Phe Ser Ser Pro Asp Gly Thr Thr Asp Asp Pro Leu Gly Gly His Thr 
    50                  55                  60                  


Val Trp Gln Val Val Phe Ile Ala Phe Leu Thr Gly Ile Leu Ala Leu 
65                  70                  75                  80  


Val Thr Ile Ile Gly Asn Ile Leu Val Ile Val Ser Phe Lys Val Asn 
                85                  90                  95      


Lys Gln Leu Lys Thr Val Asn Asn Tyr Phe Leu Leu Ser Leu Ala Cys 
            100                 105                 110         


Ala Asp Leu Ile Ile Gly Val Ile Ser Met Asn Leu Phe Thr Thr Tyr 
        115                 120                 125             


Ile Ile Met Asn Arg Trp Ala Leu Gly Asn Leu Ala Cys Asp Leu Trp 
    130                 135                 140                 


Leu Ala Ile Asp Tyr Val Ala Ser Asn Ala Ser Val Met Asn Leu Leu 
145                 150                 155                 160 


Val Ile Ser Phe Asp Arg Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr 
                165                 170                 175     


Arg Ala Lys Arg Thr Thr Lys Arg Ala Gly Val Met Ile Gly Leu Ala 
            180                 185                 190         


Trp Val Ile Ser Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln 
        195                 200                 205             


Tyr Phe Val Gly Lys Arg Thr Val Pro Pro Gly Glu Cys Phe Ile Gln 
    210                 215                 220                 


Phe Leu Ser Glu Pro Thr Ile Thr Phe Gly Thr Ala Ile Ala Ala Phe 
225                 230                 235                 240 


Tyr Met Pro Val Thr Ile Met Thr Ile Leu Tyr Trp Arg Ile Tyr Lys 
                245                 250                 255     


Glu Thr Glu Lys Arg Thr Lys Glu Leu Ala Gly Leu Gln Ala Ser Gly 
            260                 265                 270         


Thr Glu Ala Glu Thr Glu Asn Phe Val His Pro Thr Gly Ser Ser Arg 
        275                 280                 285             


Ser Cys Ser Ser Tyr Glu Leu Gln Gln Gln Ser Met Lys Arg Ser Asn 
    290                 295                 300                 


Arg Arg Lys Tyr Gly Arg Cys His Phe Trp Phe Thr Thr Lys Ser Trp 
305                 310                 315                 320 


Lys Pro Ser Ser Glu Gln Met Asp Gln Asp His Ser Ser Ser Asp Ser 
                325                 330                 335     


Trp Asn Asn Asn Asp Ala Ala Ala Ser Leu Glu Asn Ser Ala Ser Ser 
            340                 345                 350         


Asp Glu Glu Asp Ile Gly 
        355             


<210>  7531
<211>  1645
<212>  DNA
<213>  Homosapiens

<400>  7531
atcgccagaa tggctgaacc caggcgcttt ctacggctct ctttcctctt ggtcagctcc     60

aagtatgaga tttatgaacg ttgaagaggt tcattgattc accattgtgg tacaggatgt    120

tgacagcaaa gaagggcgaa cgctgttgga gaagctgttc agccagcagg agaacgggcc    180

tccagaagaa gcagagaagt tttgctcccg gatcattgcc atgggtcttc tccttccttt    240

tagtgattgc ttcagggaac cgtgtaatca gaatgcccag acgaatgcag cttcgtttga    300

tcaagatcaa ctttatacct gggctgcagt tagtcaaccc acacactcat tggactattc    360

agaagggcag tttcctaggc gagttccatc catggggcca ccatccaaac ctcccgatga    420

ggaacacagg ctcgaggatg ctgaaacaga ggatgatgga gaatctcaat ctgctgtttc    480

agaaactccc caaaaacgct cagatgctgt ccagaaggaa gttgttgaca tgaagtctga    540

gggacaggcc actgtaattc agcagctgga acagactatt gaggatctga gaaccaaaat    600

agctgaacta gagaggcagt atcctgccct ggacacagag gtggccagtg gtcatcaagg    660

gcttgagaat ggagtgacag cctcaggcga tgtctgtctc gaagctctca ggttagaaga    720

aaaggaagta cggcatcata ggattttaga ggcgaaatcg atacagactt cccccacgga    780

agagggcggg gtgctgacac tgcctcctgt ggatgggctg ccagggcgtc ctccatgccc    840

ccctggggct gaaagtggac ctcagacaaa gttctgttca gagatttctt tgattgtgtc    900

tccaaggcga atatcagtcc agctcgacag ccatcagccc acacagagca tctcacagcc    960

tccaccacct ccatcccttc tgtggtctgc tgggcaagga cagcctgggt cacagccgcc   1020

ccattctatt tctaccgagt ttcaaaccag ccacgaacac tctgtttcct ctgcctttaa   1080

aaacagctgt aacatcccat ctccaccacc tctgccttgc acagagtcct ccagctccat   1140

gcctggcctg ggcatggtgc ctcccccacc tccccctctc cctggcatga cagtgcctac   1200

tctgcccagt acagccattc cccaacctcc tcctctgcag ggtacagaaa tgctgccacc   1260

ccctccccct cctcttcccg gagcgggcat acctcctccg ccgcctctac ccggagcagg   1320

catactccct ctgccccctc tacccggagc gggaatacct cctccgcccc ctctacccgg   1380

agcggcaata ccccctccgc cccctcttcc cggggcaggc ataccccttc ctccccctct   1440

tcccggagca ggaatacctc ctccaccccc tctacccgga gcgggcatac cccctcctcc   1500

cccacttccc ggagcgggca taccccctcc gcccccactt cccggagcgg gcataccccc   1560

tcctccccct cttcccggag cgggcatacc tcctccaccc cctctacccg gagcgggcat   1620

accccctccg cccccacttc ccgga                                         1645


<210>  7532
<211>  474
<212>  PRT
<213>  Homosapiens

<400>  7532

Met Gly Leu Leu Leu Pro Phe Ser Asp Cys Phe Arg Glu Pro Cys Asn 
1               5                   10                  15      


Gln Asn Ala Gln Thr Asn Ala Ala Ser Phe Asp Gln Asp Gln Leu Tyr 
            20                  25                  30          


Thr Trp Ala Ala Val Ser Gln Pro Thr His Ser Leu Asp Tyr Ser Glu 
        35                  40                  45              


Gly Gln Phe Pro Arg Arg Val Pro Ser Met Gly Pro Pro Ser Lys Pro 
    50                  55                  60                  


Pro Asp Glu Glu His Arg Leu Glu Asp Ala Glu Thr Glu Asp Asp Gly 
65                  70                  75                  80  


Glu Ser Gln Ser Ala Val Ser Glu Thr Pro Gln Lys Arg Ser Asp Ala 
                85                  90                  95      


Val Gln Lys Glu Val Val Asp Met Lys Ser Glu Gly Gln Ala Thr Val 
            100                 105                 110         


Ile Gln Gln Leu Glu Gln Thr Ile Glu Asp Leu Arg Thr Lys Ile Ala 
        115                 120                 125             


Glu Leu Glu Arg Gln Tyr Pro Ala Leu Asp Thr Glu Val Ala Ser Gly 
    130                 135                 140                 


His Gln Gly Leu Glu Asn Gly Val Thr Ala Ser Gly Asp Val Cys Leu 
145                 150                 155                 160 


Glu Ala Leu Arg Leu Glu Glu Lys Glu Val Arg His His Arg Ile Leu 
                165                 170                 175     


Glu Ala Lys Ser Ile Gln Thr Ser Pro Thr Glu Glu Gly Gly Val Leu 
            180                 185                 190         


Thr Leu Pro Pro Val Asp Gly Leu Pro Gly Arg Pro Pro Cys Pro Pro 
        195                 200                 205             


Gly Ala Glu Ser Gly Pro Gln Thr Lys Phe Cys Ser Glu Ile Ser Leu 
    210                 215                 220                 


Ile Val Ser Pro Arg Arg Ile Ser Val Gln Leu Asp Ser His Gln Pro 
225                 230                 235                 240 


Thr Gln Ser Ile Ser Gln Pro Pro Pro Pro Pro Ser Leu Leu Trp Ser 
                245                 250                 255     


Ala Gly Gln Gly Gln Pro Gly Ser Gln Pro Pro His Ser Ile Ser Thr 
            260                 265                 270         


Glu Phe Gln Thr Ser His Glu His Ser Val Ser Ser Ala Phe Lys Asn 
        275                 280                 285             


Ser Cys Asn Ile Pro Ser Pro Pro Pro Leu Pro Cys Thr Glu Ser Ser 
    290                 295                 300                 


Ser Ser Met Pro Gly Leu Gly Met Val Pro Pro Pro Pro Pro Pro Leu 
305                 310                 315                 320 


Pro Gly Met Thr Val Pro Thr Leu Pro Ser Thr Ala Ile Pro Gln Pro 
                325                 330                 335     


Pro Pro Leu Gln Gly Thr Glu Met Leu Pro Pro Pro Pro Pro Pro Leu 
            340                 345                 350         


Pro Gly Ala Gly Ile Pro Pro Pro Pro Pro Leu Pro Gly Ala Gly Ile 
        355                 360                 365             


Leu Pro Leu Pro Pro Leu Pro Gly Ala Gly Ile Pro Pro Pro Pro Pro 
    370                 375                 380                 


Leu Pro Gly Ala Ala Ile Pro Pro Pro Pro Pro Leu Pro Gly Ala Gly 
385                 390                 395                 400 


Ile Pro Leu Pro Pro Pro Leu Pro Gly Ala Gly Ile Pro Pro Pro Pro 
                405                 410                 415     


Pro Leu Pro Gly Ala Gly Ile Pro Pro Pro Pro Pro Leu Pro Gly Ala 
            420                 425                 430         


Gly Ile Pro Pro Pro Pro Pro Leu Pro Gly Ala Gly Ile Pro Pro Pro 
        435                 440                 445             


Pro Pro Leu Pro Gly Ala Gly Ile Pro Pro Pro Pro Pro Leu Pro Gly 
    450                 455                 460                 


Ala Gly Ile Pro Pro Pro Pro Pro Leu Pro 
465                 470                 


<210>  7533
<211>  6024
<212>  DNA
<213>  Homosapiens

<400>  7533
atgcattcga ttcgcacggt ggagattaaa gtccccgaga tagaggaaac gtttttcgcg     60

cccagccgca gccgcagccg cagcgacggc agccacggga gccgccgcgc attatgcaaa    120

gcggcggcag atgcgagcgg ggccagccgg gcgcgcgtcg gcctcccctc ccagcggctc    180

cccccgccgc cgcctgactc tcccgggaga ctccctaggc ccggacctgg ggccgaggag    240

ggccgggatg gcctgagtgc ccgcggcgcg gcggcgcagc agcgggattg caccatgggg    300

aaccaggatg ggaagctgaa gaggagcgca ggtgatgctt tgcacgaagg cggcggtggc    360

gccgaggatg cgctggggcc cagggatgtg gaagccacaa agaaggggag cgggggcaag    420

aaggcgctag gcaagcacgg caagggggga gggggcggcg gcggcggcgg ggagtcgggc    480

aagaagaaga gcaagtccga ctccagagcc tcggtgtttt ccaacctgcg gatcaggaag    540

aatctgtcca aggggaaagg cgccggcggc tcccgcgaag atgtactgga ttcccaggcc    600

ctgcagaccg gggagctgga cagcgctcac tccctgctca ccaagactcc agacctcagc    660

ctctcggcgg acgaggccgg cctgtcggat accgagtgtg cggacccttt tgaggtgacc    720

ggtccagggg gtcctgggcc tgccgaggct aggggcgccg aggagcctgc agcgcccccc    780

actgccgtct cccctcagcc cggggccttc ctgggcctgg accggttcct gctggggccg    840

agcggcgggg ctggggaggc cccgggcagt ccggacaccg agcaggcgct gtccgcgctc    900

tccgacctgc ccgagagcct ggccgccgag ccccgggagc cccagcaacc gccgtccccc    960

ggcggcctcc cggtctccga ggcgcccagt ctcccggcag cgcaacccgc ggccaaagac   1020

tcgccctcct ccacggcttt cccatttccc gaggccgggc cgggggagga agcggccgga   1080

gcccccgtgc gaggggctgg ggacacggat gaggagggtg aggaggatgc ttttgaggat   1140

gcgccccggg gctctccggg ggaggagtgg gccccggagg tgggagagga cgccccgcag   1200

aggctggggg aagagccgga ggaggaggcg caaggacctg acgcccccgc ggccgcttcc   1260

ctgcccggca gccccgcgcc tagccagcgc tgtttcaagc cctacccgct catcaccccc   1320

tgctacatca agaccaccac ccggcagctc agctcgccca atcactcccc gtctcagtcc   1380

cctaatcaga gccccaggat caagaggcgg ccggaaccct ccctgagccg agggtccaga   1440

actgccctgg cctccgtagc cgccccggcc aagaagcacc gggccgacgg cggccttgcg   1500

gccggcctga gccgctcggc tgactggacg gaggagctag gcgcccgcac gccccgggtg   1560

ggaggctccg cgcacctgct ggagcgcggg gtggcgagtg acagcggcgg tggggtgtcc   1620

ccagcactgg ccgccaaggc gtctggggcc cccgcggctg cggatggctt ccagaacgtg   1680

ttcacagggc gaacgctgtt ggagaagctg ttcagccagc aggagaacgg gcctccagaa   1740

gaagcagaga agttttgctc ccggatcatt gccatgggtc ttctccttcc ttttagtgat   1800

tgcttcaggg aaccgtgtaa tcagaatgcc cagacgaatg cagcttcgtt tgatcaagat   1860

caactttata cctgggctgc agttagtcaa cccacacact cattggacta ttcagaaggg   1920

cagtttccta ggcgagttcc atccatgggg ccaccatcca aacctcccga tgaggaacac   1980

aggctcgagg atgctgaaac agaatctcaa tctgctgttt cagaaactcc ccaaaaacgc   2040

tcagatgctg tccagaagga agttgttgac atgaagtctg agggacaggc cactgtaatt   2100

cagcagctgg aacagactat tgaggatctg agaaccaaaa tagctgaact agagaggcag   2160

tatcctgccc tggacacaga ggtggccagt ggtcatcaag ggcttgagaa tggagtgaca   2220

gcctcaggcg atgtctgtct cgaagctctc aggttagaag aaaaggaagt acggcatcat   2280

aggattttag aggcgaaatc gatacagact tcccccacgg aagagggcgg ggtgctgaca   2340

ctgcctcctg tggatgggct gccagggcgt cctccatgcc cccctggggc tgaaagtgga   2400

cctcagacaa agttctgttc agagatttct ttgattgtgt ctccaaggcg aatatcagtc   2460

cagctcgaca gccatcagcc cacacagagc atctcacagc ctccaccacc tccatccctt   2520

ctgtggtctg ctgggcaagg acagcctggg tcacagccgc cccattctat ttctaccgag   2580

tttcaaacca gccacgaaca ctctgtttcc tctgccttta aaaacagctg taacatccca   2640

tctccaccac ctctgccttg cacagagtcc tccagctcca tgcctggcct gggcatggtg   2700

cctcccccac ctccccctct ccctggcatg acagtgccta ctctgcccag tacagccatt   2760

ccccaacctc ctcctctgca gggtacagaa atgctgccac cccctccccc tcctcttccc   2820

ggagcgggca tacctcctcc gccgcctcta cccggagcag gcatactccc tctgccccct   2880

ctacccggag cgggaatacc tcctccgccc cctctacccg gagcggcaat accccctccg   2940

ccccctcttc ccggggcagg catacccctt cctccccctc ttcccggagc aggaatacct   3000

cctccacccc ctctacccgg agcgggcata ccccctcctc ccccacttcc cggagcgggc   3060

ataccccctc cgcccccact tcccggagcg ggcatacccc ctcctccccc tcttcccgga   3120

gcgggcatac ctcctccacc ccctctaccc ggagcgggca taccccctcc gcccccactt   3180

cccggagcgg gcataccccc tccgccccca cttcccggag cgggcatacc ccctcctccc   3240

cctcttcccg gagcgggcat acctcctcca ccccctctac ccggagcggg cataccccct   3300

ccgcccccac ttcccggagc gggcataccc ccacctcccc ctctacccgg agcgggcata   3360

ccccctccgc cccctctacc cggagtgggc atacctcctc cgccccctct acccggagcg   3420

ggcatacccc ctcctccccc tctacccgga gcgggcatac cccctcctcc ccctcttccc   3480

ggagcgggca tacctcctcc accccctcta cccagagtgg gcataccccc tccgccccca   3540

cttcccggag cgggcatacc cccacctccc cctctacccg gagcgggcat accccctccg   3600

ccccctctac ctggagtggg aatacctcct ccgccccctc tacctggagt gggaatacct   3660

cctccgcccc ctctacctgg tgctgggatt cccccacctc ctcccttgcc aggtatgggg   3720

attccacctg ctccagctcc cccactccct ccacctggga caggaatccc accgccccct   3780

ctgcttcctg tatcaggccc tccactcctc ccacaagttg ggagtagcac tttaccaacc   3840

ccacaggtgt gtggatttct tcctcctcca ttgccaagtg gcttgtttgg attagggatg   3900

aatcaggaca aagggagtag gaagcagccc atagagcctt gtcgaccaat gaagcctctt   3960

tactggacca ggattcaact acatagtaaa agagactcca gtacttcact tatttgggaa   4020

aaaattgaag agccatccat agattgtcat gaatttgagg aattattttc taaaactgct   4080

gtaaaggaga gaaagaaacc tatctctgat actatctcaa agacgaaggc taaacaagtt   4140

gtcaagttat taagcaacaa aagatcacaa gcagttggaa tactaatgtc tagccttcat   4200

ttagatatga aagacataca acatgctgtt gtgaacttgg ataattctgt ggttgacctg   4260

gagacccttc aagctctcta tgagaataga gcacagtcag acgaactcga aaaaatagaa   4320

aagcatggcc gatcttccaa agacaaggaa aatgccaagt ctctggacaa acctgaacag   4380

ttcctttatg aactgtcact aatccccaac ttttcagagc gagtcttttg catcctgttc   4440

cagtccacat tttcagaaag catttgctca attcgtcgca aactggaatt actacagaaa   4500

ttgtgtgaga cattaaaaaa tggcccaggg gttatgcagg ttctaggttt ggttcttgcc   4560

tttggcaact acatgaatgg aggaaataag actcgaggac aggcagatgg ctttggatta   4620

gacattcttc caaaactgaa agatgtcaag agcagtgaca atagcagaag ccttttgtca   4680

tatattgttt cgtattatct ccgaaatttt gatgaggatg ctggaaaaga acagtgcctc   4740

tttccactgc cagaacccca ggaccttttt caggcctcac agatgaagtt tgaagatttt   4800

caaaaagatc tcagaaaact gaagaaagac ttgaaagcct gtgaagttga agcagggaaa   4860

gtataccagg tctcctcaaa agagcatatg cagcctttca aggaaaacat ggaacaattt   4920

attattcaag ccaaaattga ccaagaggca gaggaaaatt cactgacaga gactcataaa   4980

tgctttttgg agaccacggc atatttcttc atgaaaccaa aacttggaga gaaggaggtg   5040

tccccaaatg ctttcttcag tatctggcat gaattcagct ctgactttaa agacttctgg   5100

aagaaagaga acaaacttct tctacaagag agagtaaaag aagccgaaga ggtgtgtaga   5160

cagaagaaag gaaaatcact ttataaaata aaaccaagac atgactctgg aattaaagca   5220

aagataagca tgaaaacttg aacaatgaaa agcagaatga aaatgagtca ttgcaacgac   5280

tttcacaaaa ttcagctgac ctgagagtgg gagggaaact accgtcattc tgctcatgtt   5340

tcttcttgac ctcttgcata atctttttgt tttctagaca gttcactaat tgttgaattt   5400

tactgtatat tcatataaaa atgcaaacgt actagaccag tggagaattt gacacctttt   5460

ctttttgtaa aagtttatgg tattataccg atagaccaaa acagcatgtg taagaggcag   5520

tatctgcact aattctcaac atgctaaaca ttaactacaa ttcactgttg tgagaatatt   5580

cctcgtcaca gcaaaaacac tttcctttct actgacaacc agtcctccac atcacagcat   5640

ttagacatat gggtaaaatg ttatttctag tgaattgttt gtatcagttt catgtctaag   5700

tataaatttt ctattttaaa caacttaaga aaaccaatgt tctaaatcat aattgtttgt   5760

atttatgtaa agtatggtct cttacttttt agtttgtagt ttaagtgcaa agaaacagta   5820

gtggtttttt ttctattgtt ttgtagtctt cctgtcccct tcagtccctc cagtgtgtat   5880

attaccattc tccaatgaaa taatagggca tttaacaaag atcgctatgt gcaatactgt   5940

atttagtgtt tctatttcaa tttttctagg atgttaattt atatgaaaat aaaatgaata   6000

ataaaagaat aaagatactt gcaa                                          6024


<210>  7534
<211>  1746
<212>  PRT
<213>  Homosapiens

<400>  7534

Met His Ser Ile Arg Thr Val Glu Ile Lys Val Pro Glu Ile Glu Glu 
1               5                   10                  15      


Thr Phe Phe Ala Pro Ser Arg Ser Arg Ser Arg Ser Asp Gly Ser His 
            20                  25                  30          


Gly Ser Arg Arg Ala Leu Cys Lys Ala Ala Ala Asp Ala Ser Gly Ala 
        35                  40                  45              


Ser Arg Ala Arg Val Gly Leu Pro Ser Gln Arg Leu Pro Pro Pro Pro 
    50                  55                  60                  


Pro Asp Ser Pro Gly Arg Leu Pro Arg Pro Gly Pro Gly Ala Glu Glu 
65                  70                  75                  80  


Gly Arg Asp Gly Leu Ser Ala Arg Gly Ala Ala Ala Gln Gln Arg Asp 
                85                  90                  95      


Cys Thr Met Gly Asn Gln Asp Gly Lys Leu Lys Arg Ser Ala Gly Asp 
            100                 105                 110         


Ala Leu His Glu Gly Gly Gly Gly Ala Glu Asp Ala Leu Gly Pro Arg 
        115                 120                 125             


Asp Val Glu Ala Thr Lys Lys Gly Ser Gly Gly Lys Lys Ala Leu Gly 
    130                 135                 140                 


Lys His Gly Lys Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ser Gly 
145                 150                 155                 160 


Lys Lys Lys Ser Lys Ser Asp Ser Arg Ala Ser Val Phe Ser Asn Leu 
                165                 170                 175     


Arg Ile Arg Lys Asn Leu Ser Lys Gly Lys Gly Ala Gly Gly Ser Arg 
            180                 185                 190         


Glu Asp Val Leu Asp Ser Gln Ala Leu Gln Thr Gly Glu Leu Asp Ser 
        195                 200                 205             


Ala His Ser Leu Leu Thr Lys Thr Pro Asp Leu Ser Leu Ser Ala Asp 
    210                 215                 220                 


Glu Ala Gly Leu Ser Asp Thr Glu Cys Ala Asp Pro Phe Glu Val Thr 
225                 230                 235                 240 


Gly Pro Gly Gly Pro Gly Pro Ala Glu Ala Arg Gly Ala Glu Glu Pro 
                245                 250                 255     


Ala Ala Pro Pro Thr Ala Val Ser Pro Gln Pro Gly Ala Phe Leu Gly 
            260                 265                 270         


Leu Asp Arg Phe Leu Leu Gly Pro Ser Gly Gly Ala Gly Glu Ala Pro 
        275                 280                 285             


Gly Ser Pro Asp Thr Glu Gln Ala Leu Ser Ala Leu Ser Asp Leu Pro 
    290                 295                 300                 


Glu Ser Leu Ala Ala Glu Pro Arg Glu Pro Gln Gln Pro Pro Ser Pro 
305                 310                 315                 320 


Gly Gly Leu Pro Val Ser Glu Ala Pro Ser Leu Pro Ala Ala Gln Pro 
                325                 330                 335     


Ala Ala Lys Asp Ser Pro Ser Ser Thr Ala Phe Pro Phe Pro Glu Ala 
            340                 345                 350         


Gly Pro Gly Glu Glu Ala Ala Gly Ala Pro Val Arg Gly Ala Gly Asp 
        355                 360                 365             


Thr Asp Glu Glu Gly Glu Glu Asp Ala Phe Glu Asp Ala Pro Arg Gly 
    370                 375                 380                 


Ser Pro Gly Glu Glu Trp Ala Pro Glu Val Gly Glu Asp Ala Pro Gln 
385                 390                 395                 400 


Arg Leu Gly Glu Glu Pro Glu Glu Glu Ala Gln Gly Pro Asp Ala Pro 
                405                 410                 415     


Ala Ala Ala Ser Leu Pro Gly Ser Pro Ala Pro Ser Gln Arg Cys Phe 
            420                 425                 430         


Lys Pro Tyr Pro Leu Ile Thr Pro Cys Tyr Ile Lys Thr Thr Thr Arg 
        435                 440                 445             


Gln Leu Ser Ser Pro Asn His Ser Pro Ser Gln Ser Pro Asn Gln Ser 
    450                 455                 460                 


Pro Arg Ile Lys Arg Arg Pro Glu Pro Ser Leu Ser Arg Gly Ser Arg 
465                 470                 475                 480 


Thr Ala Leu Ala Ser Val Ala Ala Pro Ala Lys Lys His Arg Ala Asp 
                485                 490                 495     


Gly Gly Leu Ala Ala Gly Leu Ser Arg Ser Ala Asp Trp Thr Glu Glu 
            500                 505                 510         


Leu Gly Ala Arg Thr Pro Arg Val Gly Gly Ser Ala His Leu Leu Glu 
        515                 520                 525             


Arg Gly Val Ala Ser Asp Ser Gly Gly Gly Val Ser Pro Ala Leu Ala 
    530                 535                 540                 


Ala Lys Ala Ser Gly Ala Pro Ala Ala Ala Asp Gly Phe Gln Asn Val 
545                 550                 555                 560 


Phe Thr Gly Arg Thr Leu Leu Glu Lys Leu Phe Ser Gln Gln Glu Asn 
                565                 570                 575     


Gly Pro Pro Glu Glu Ala Glu Lys Phe Cys Ser Arg Ile Ile Ala Met 
            580                 585                 590         


Gly Leu Leu Leu Pro Phe Ser Asp Cys Phe Arg Glu Pro Cys Asn Gln 
        595                 600                 605             


Asn Ala Gln Thr Asn Ala Ala Ser Phe Asp Gln Asp Gln Leu Tyr Thr 
    610                 615                 620                 


Trp Ala Ala Val Ser Gln Pro Thr His Ser Leu Asp Tyr Ser Glu Gly 
625                 630                 635                 640 


Gln Phe Pro Arg Arg Val Pro Ser Met Gly Pro Pro Ser Lys Pro Pro 
                645                 650                 655     


Asp Glu Glu His Arg Leu Glu Asp Ala Glu Thr Glu Ser Gln Ser Ala 
            660                 665                 670         


Val Ser Glu Thr Pro Gln Lys Arg Ser Asp Ala Val Gln Lys Glu Val 
        675                 680                 685             


Val Asp Met Lys Ser Glu Gly Gln Ala Thr Val Ile Gln Gln Leu Glu 
    690                 695                 700                 


Gln Thr Ile Glu Asp Leu Arg Thr Lys Ile Ala Glu Leu Glu Arg Gln 
705                 710                 715                 720 


Tyr Pro Ala Leu Asp Thr Glu Val Ala Ser Gly His Gln Gly Leu Glu 
                725                 730                 735     


Asn Gly Val Thr Ala Ser Gly Asp Val Cys Leu Glu Ala Leu Arg Leu 
            740                 745                 750         


Glu Glu Lys Glu Val Arg His His Arg Ile Leu Glu Ala Lys Ser Ile 
        755                 760                 765             


Gln Thr Ser Pro Thr Glu Glu Gly Gly Val Leu Thr Leu Pro Pro Val 
    770                 775                 780                 


Asp Gly Leu Pro Gly Arg Pro Pro Cys Pro Pro Gly Ala Glu Ser Gly 
785                 790                 795                 800 


Pro Gln Thr Lys Phe Cys Ser Glu Ile Ser Leu Ile Val Ser Pro Arg 
                805                 810                 815     


Arg Ile Ser Val Gln Leu Asp Ser His Gln Pro Thr Gln Ser Ile Ser 
            820                 825                 830         


Gln Pro Pro Pro Pro Pro Ser Leu Leu Trp Ser Ala Gly Gln Gly Gln 
        835                 840                 845             


Pro Gly Ser Gln Pro Pro His Ser Ile Ser Thr Glu Phe Gln Thr Ser 
    850                 855                 860                 


His Glu His Ser Val Ser Ser Ala Phe Lys Asn Ser Cys Asn Ile Pro 
865                 870                 875                 880 


Ser Pro Pro Pro Leu Pro Cys Thr Glu Ser Ser Ser Ser Met Pro Gly 
                885                 890                 895     


Leu Gly Met Val Pro Pro Pro Pro Pro Pro Leu Pro Gly Met Thr Val 
            900                 905                 910         


Pro Thr Leu Pro Ser Thr Ala Ile Pro Gln Pro Pro Pro Leu Gln Gly 
        915                 920                 925             


Thr Glu Met Leu Pro Pro Pro Pro Pro Pro Leu Pro Gly Ala Gly Ile 
    930                 935                 940                 


Pro Pro Pro Pro Pro Leu Pro Gly Ala Gly Ile Leu Pro Leu Pro Pro 
945                 950                 955                 960 


Leu Pro Gly Ala Gly Ile Pro Pro Pro Pro Pro Leu Pro Gly Ala Ala 
                965                 970                 975     


Ile Pro Pro Pro Pro Pro Leu Pro Gly Ala Gly Ile Pro Leu Pro Pro 
            980                 985                 990         


Pro Leu Pro Gly Ala Gly Ile Pro  Pro Pro Pro Pro Leu  Pro Gly Ala 
        995                 1000                 1005             


Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly Ala Gly  Ile Pro Pro 
    1010                 1015                 1020             


Pro Pro  Pro Leu Pro Gly Ala  Gly Ile Pro Pro Pro  Pro Pro Leu 
    1025                 1030                 1035             


Pro Gly  Ala Gly Ile Pro Pro  Pro Pro Pro Leu Pro  Gly Ala Gly 
    1040                 1045                 1050             


Ile Pro  Pro Pro Pro Pro Leu  Pro Gly Ala Gly Ile  Pro Pro Pro 
    1055                 1060                 1065             


Pro Pro  Leu Pro Gly Ala Gly  Ile Pro Pro Pro Pro  Pro Leu Pro 
    1070                 1075                 1080             


Gly Ala  Gly Ile Pro Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile 
    1085                 1090                 1095             


Pro Pro  Pro Pro Pro Leu Pro  Gly Ala Gly Ile Pro  Pro Pro Pro 
    1100                 1105                 1110             


Pro Leu  Pro Gly Ala Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly 
    1115                 1120                 1125             


Val Gly  Ile Pro Pro Pro Pro  Pro Leu Pro Gly Ala  Gly Ile Pro 
    1130                 1135                 1140             


Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile Pro Pro  Pro Pro Pro 
    1145                 1150                 1155             


Leu Pro  Gly Ala Gly Ile Pro  Pro Pro Pro Pro Leu  Pro Arg Val 
    1160                 1165                 1170             


Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly Ala Gly  Ile Pro Pro 
    1175                 1180                 1185             


Pro Pro  Pro Leu Pro Gly Ala  Gly Ile Pro Pro Pro  Pro Pro Leu 
    1190                 1195                 1200             


Pro Gly  Val Gly Ile Pro Pro  Pro Pro Pro Leu Pro  Gly Val Gly 
    1205                 1210                 1215             


Ile Pro  Pro Pro Pro Pro Leu  Pro Gly Ala Gly Ile  Pro Pro Pro 
    1220                 1225                 1230             


Pro Pro  Leu Pro Gly Met Gly  Ile Pro Pro Ala Pro  Ala Pro Pro 
    1235                 1240                 1245             


Leu Pro  Pro Pro Gly Thr Gly  Ile Pro Pro Pro Pro  Leu Leu Pro 
    1250                 1255                 1260             


Val Ser  Gly Pro Pro Leu Leu  Pro Gln Val Gly Ser  Ser Thr Leu 
    1265                 1270                 1275             


Pro Thr  Pro Gln Val Cys Gly  Phe Leu Pro Pro Pro  Leu Pro Ser 
    1280                 1285                 1290             


Gly Leu  Phe Gly Leu Gly Met  Asn Gln Asp Lys Gly  Ser Arg Lys 
    1295                 1300                 1305             


Gln Pro  Ile Glu Pro Cys Arg  Pro Met Lys Pro Leu  Tyr Trp Thr 
    1310                 1315                 1320             


Arg Ile  Gln Leu His Ser Lys  Arg Asp Ser Ser Thr  Ser Leu Ile 
    1325                 1330                 1335             


Trp Glu  Lys Ile Glu Glu Pro  Ser Ile Asp Cys His  Glu Phe Glu 
    1340                 1345                 1350             


Glu Leu  Phe Ser Lys Thr Ala  Val Lys Glu Arg Lys  Lys Pro Ile 
    1355                 1360                 1365             


Ser Asp  Thr Ile Ser Lys Thr  Lys Ala Lys Gln Val  Val Lys Leu 
    1370                 1375                 1380             


Leu Ser  Asn Lys Arg Ser Gln  Ala Val Gly Ile Leu  Met Ser Ser 
    1385                 1390                 1395             


Leu His  Leu Asp Met Lys Asp  Ile Gln His Ala Val  Val Asn Leu 
    1400                 1405                 1410             


Asp Asn  Ser Val Val Asp Leu  Glu Thr Leu Gln Ala  Leu Tyr Glu 
    1415                 1420                 1425             


Asn Arg  Ala Gln Ser Asp Glu  Leu Glu Lys Ile Glu  Lys His Gly 
    1430                 1435                 1440             


Arg Ser  Ser Lys Asp Lys Glu  Asn Ala Lys Ser Leu  Asp Lys Pro 
    1445                 1450                 1455             


Glu Gln  Phe Leu Tyr Glu Leu  Ser Leu Ile Pro Asn  Phe Ser Glu 
    1460                 1465                 1470             


Arg Val  Phe Cys Ile Leu Phe  Gln Ser Thr Phe Ser  Glu Ser Ile 
    1475                 1480                 1485             


Cys Ser  Ile Arg Arg Lys Leu  Glu Leu Leu Gln Lys  Leu Cys Glu 
    1490                 1495                 1500             


Thr Leu  Lys Asn Gly Pro Gly  Val Met Gln Val Leu  Gly Leu Val 
    1505                 1510                 1515             


Leu Ala  Phe Gly Asn Tyr Met  Asn Gly Gly Asn Lys  Thr Arg Gly 
    1520                 1525                 1530             


Gln Ala  Asp Gly Phe Gly Leu  Asp Ile Leu Pro Lys  Leu Lys Asp 
    1535                 1540                 1545             


Val Lys  Ser Ser Asp Asn Ser  Arg Ser Leu Leu Ser  Tyr Ile Val 
    1550                 1555                 1560             


Ser Tyr  Tyr Leu Arg Asn Phe  Asp Glu Asp Ala Gly  Lys Glu Gln 
    1565                 1570                 1575             


Cys Leu  Phe Pro Leu Pro Glu  Pro Gln Asp Leu Phe  Gln Ala Ser 
    1580                 1585                 1590             


Gln Met  Lys Phe Glu Asp Phe  Gln Lys Asp Leu Arg  Lys Leu Lys 
    1595                 1600                 1605             


Lys Asp  Leu Lys Ala Cys Glu  Val Glu Ala Gly Lys  Val Tyr Gln 
    1610                 1615                 1620             


Val Ser  Ser Lys Glu His Met  Gln Pro Phe Lys Glu  Asn Met Glu 
    1625                 1630                 1635             


Gln Phe  Ile Ile Gln Ala Lys  Ile Asp Gln Glu Ala  Glu Glu Asn 
    1640                 1645                 1650             


Ser Leu  Thr Glu Thr His Lys  Cys Phe Leu Glu Thr  Thr Ala Tyr 
    1655                 1660                 1665             


Phe Phe  Met Lys Pro Lys Leu  Gly Glu Lys Glu Val  Ser Pro Asn 
    1670                 1675                 1680             


Ala Phe  Phe Ser Ile Trp His  Glu Phe Ser Ser Asp  Phe Lys Asp 
    1685                 1690                 1695             


Phe Trp  Lys Lys Glu Asn Lys  Leu Leu Leu Gln Glu  Arg Val Lys 
    1700                 1705                 1710             


Glu Ala  Glu Glu Val Cys Arg  Gln Lys Lys Gly Lys  Ser Leu Tyr 
    1715                 1720                 1725             


Lys Ile  Lys Pro Arg His Asp  Ser Gly Ile Lys Ala  Lys Ile Ser 
    1730                 1735                 1740             


Met Lys  Thr 
    1745     


<210>  7535
<211>  315
<212>  DNA
<213>  Homosapiens

<400>  7535
cccaatctca acagtggctc accatatgta ctctctcccc atgtaaattt ctttagaacc     60

caaagcctca gttttttatg gagttcttct tttgcttgaa ttggccaaga ctttctttac    120

ttccccccga ccaccacaca cacacacaat tgaaacaaaa tacatacaca ggccgggggc    180

ggtggctcac acctttaatc tcactactcc ggaggctgag gcagaagaat cgcttgaacc    240

cgggggtcag aggtttcagt gagctgagat ggagccactg cactccagca tggatgacag    300

agtgacaccc catct                                                     315


<210>  7536
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  7536

Met Glu Phe Phe Phe Cys Leu Asn Trp Pro Arg Leu Ser Leu Leu Pro 
1               5                   10                  15      


Pro Asp His His Thr His Thr Gln Leu Lys Gln Asn Thr Tyr Thr Gly 
            20                  25                  30          


Arg Gly Arg Trp Leu Thr Pro Leu Ile Ser Leu Leu Arg Arg Leu Arg 
        35                  40                  45              


Gln Lys Asn Arg Leu Asn Pro Gly Val Arg Gly Phe Ser Glu Leu Arg 
    50                  55                  60                  


Trp Ser His Cys Thr Pro Ala Trp Met Thr Glu 
65                  70                  75  


<210>  7537
<211>  1364
<212>  DNA
<213>  Homosapiens

<400>  7537
ctggaggccc agcagagcaa ggcttcccag gtggaaagct gttgtttcat gccttttatt     60

ttcgggccgt gtgctttttg gagaccacgg catatttctt catgaaacca aaacttggag    120

agaaggaggt gtccccaaat gctttcttca gtatctggca tgaattcagc tctgacttta    180

aagacttctg gaagaaagag aacaaacttc ttctacaaga gagagtaaaa gaagccgaag    240

aggtgtgtag acagaagaaa ggaaaatcac tttataaaat aaaaccaaga catgactctg    300

gaattaaagc aaagataagc atgaaaactt gaacaatgaa aagcagaatg aaaatgagtc    360

attgcaacga ctttcacaaa attcagctga cctgagagtg ggagggaaac taccgtcatt    420

ctgctcatgt ttcttcttga cctcttgcat aatctttttg ttttctagac agttcactaa    480

ttgttgaatt ttactgtata ttcatataaa aatgcaaacg tactagacca gtggagaatt    540

tgacaccttt tctttttgta aaagtttatg gtattatacc gatagaccaa aacagcatgt    600

gtaagaggca gtatctgcac taattctcaa catgctaaac attaactaca attcactgtt    660

gtgagaatat tcctcgtcac agcaaaaaca ctttcctttc tactgacaac cagtcctcca    720

catcacagca tttagacata tgggtaaaat gttatttcta gtgaattgtt tgtatcagtt    780

tcatgtctaa gtataaattt tctattttaa aatttaagaa ccgtttataa tcagtgcttt    840

cccaactctt gggttgctct ccataactat gtatttgtga aagaaaatgg tcattttttt    900

tactgaagtc atataatgac ttgggtcagc tcgtaatgca ttgtgatggt tttgtatgag    960

ctgggtgttt ttttccatta cttttaatga tcttcgttgc aagttatagt tgtggataaa   1020

ggggagaatt tattgctctt gcaaaccaat tatggaaagc aacttaagaa aaccaatgtt   1080

ctaaatcata attgtttgta tttatgtaaa gtatggtctc ttacttttta gtttgtagtt   1140

taagtgcaaa gaaacagtag tggttttttt tctattgttt tgtagtcttc ctgtcccctt   1200

cagtccctcc agtgtgtata ttaccattct ccaatgaaat aatagggcat ttaacaaaga   1260

tcgctatgtg caatactgta tttagtgttt ctatttcaat ttttctagga tgttaattta   1320

tatgaaaata aaatgaataa taaaagaata aagatacttg caaa                    1364


<210>  7538
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  7538

Met Lys Pro Lys Leu Gly Glu Lys Glu Val Ser Pro Asn Ala Phe Phe 
1               5                   10                  15      


Ser Ile Trp His Glu Phe Ser Ser Asp Phe Lys Asp Phe Trp Lys Lys 
            20                  25                  30          


Glu Asn Lys Leu Leu Leu Gln Glu Arg Val Lys Glu Ala Glu Glu Val 
        35                  40                  45              


Cys Arg Gln Lys Lys Gly Lys Ser Leu Tyr Lys Ile Lys Pro Arg His 
    50                  55                  60                  


Asp Ser Gly Ile Lys Ala Lys Ile Ser Met Lys Thr 
65                  70                  75      


<210>  7539
<211>  1170
<212>  DNA
<213>  Homosapiens

<400>  7539
atacacactc tgcatagaaa ttcttatgta gtaaaagaag ccgaagaggt gtgtagacag     60

aagaaaggaa aatcacttta taaaataaaa ccaagacatg actctggaat taaagcaaag    120

ataagcatga aaacttgaac aatgaaaagc agaatgaaaa tgagtcattg caacgacttt    180

cacaaaattc agctgacctg agagtgggag ggaaactacc gtcattctgc tcatgtttct    240

tcttgacctc ttgcataatc tttttgtttt ctagacagtt cactaattgt tgaattttac    300

tgtatattca tataaaaatg caaacgtact agaccagtgg agaatttgac accttttctt    360

tttgtaaaag tttatggtat tataccgata gaccaaaaca gcatgtgtaa gaggcagtat    420

ctgcactaat tctcaacatg ctaaacatta actacaattc actgttgtga gaatattcct    480

cgtcacagca aaaacacttt cctttctact gacaaccagt cctccacatc acagcattta    540

gacatatggg taaaatgtta tttctagtga attgtttgta tcagtttcat gtctaagtat    600

aaattttcta ttttaaaatt taagaaccgt ttataatcag tgctttccca actcttgggt    660

tgctctccat aactatgtat ttgtgaaaga aaatggtcat tttttttact gaagtcatat    720

aatgacttgg gtcagctcgt aatgcattgt gatggttttg tatgagctgg gtgttttttt    780

ccattacttt taatgatctt cgttgcaagt tatagttgtg gataaagggg agaatttatt    840

gctcttgcaa accaattatg gaaagcaact taagaaaacc aatgttctaa atcataattg    900

tttgtattta tgtaaagtat ggtctcttac tttttagttt gtagtttaag tgcaaagaaa    960

cagtagtggt tttttttcta ttgttttgta gtcttcctgt ccccttcagt ccctccagtg   1020

tgtatattac cattctccaa tgaaataata gggcatttaa caaagatcgc tatgtgcaat   1080

actgtattta gtgtttctat ttcaattttt ctaggatgtt aatttatatg aaaataaaat   1140

gaataataaa agaataaaga tacttgcaaa                                    1170


<210>  7540
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  7540

Ser Lys Asp Lys His Glu Asn Leu Asn Asn Glu Lys Gln Asn Glu Asn 
1               5                   10                  15      


Glu Ser Leu Gln Arg Leu Ser Gln Asn Ser Ala Asp Leu Arg Val Gly 
            20                  25                  30          


Gly Lys Leu Pro Ser Phe Cys Ser Cys Phe Phe Leu Thr Ser Cys Ile 
        35                  40                  45              


Ile Phe Leu Phe Ser Arg Gln Phe Thr Asn Cys 
    50                  55                  


<210>  7541
<211>  4177
<212>  DNA
<213>  Homosapiens

<400>  7541
ttcagagcta agtctccggg ctcctttcac atctgcagga gcagccagcc tgggaccgcg     60

cggcgcgggg cgcgctctcg cctctcctgc accctcagcc ggcgcgcttc tcttatgggc    120

gtctgctgca gtctggctgc ggtcgaactg aaagcggcgg cgggagacca aacttagacc    180

ccgctgtgga ctagagaact cagagaaggc agagggagag ggagagagag agagagaagg    240

gacccgagga ggaggcttcc atcacgtcat tgcaggatgt tctggaagct ttccctgtcc    300

ttgttcctgg tggcggtgct ggtgaaggtg gcggaagccc ggaagaaccg gccggcgggc    360

gccatcccct cgccttacaa ggacggcagc agcaacaact cggagagatg gcagcaccag    420

atcaaggagg tgctggcctc cagccaggag gccctggtgg tcaccgagcg caagtacctc    480

aagagtgact ggtgcaagac gcagccgctg cggcagacgg tgagcgagga gggctgccgg    540

agccgcacca tcctcaaccg cttctgctac ggccagtgca actccttcta catcccgcgg    600

cacgtgaaga aggaggagga gtccttccag tcctgcgcct tctgcaagcc ccagcgcgtc    660

acctccgtcc tcgtggagct cgagtgcccc ggcctggacc cacccttccg actcaagaaa    720

atccagaagg tgaagcagtg ccggtgcatg tccgtgaacc tgagcgactc ggacaagcag    780

tgagcgccgg gccggacgca gctcagcccc gcgcgcgccc ggccgctggg tggcgccgcc    840

gccgcctctg tccctgccct ccgagcccac tgtcacgctg cctggtgttc cccctcagca    900

gcaagcactt ctcttagggc tgacggtgtc cttgtcacag acgtggatcg caagtggagc    960

ttttgctgat gtgttcctga ccgaccccgg gtcccacctg tgccccctaa accaggcggt   1020

ggatcaggcc cgaaggaaaa tgctggaaaa ccaccaccgc cacccagcag tcagagagga   1080

cctttcgagg tgatgcactg taaatccggc attgatgttt ccaccatgtg gaaaagcaag   1140

gatttccctg gccccgccct gcactccagc tcgccccttt cccgcgcgaa gtgaaggatg   1200

cgtcactttt ctgagcggcc cctcagacct ctcctgctgg tccctggacc tctggctggg   1260

agcgctcatt cttgtgactg gcaggctgcc ctcggtcgct gctgtgatga ggatatgtgc   1320

aacctccata aatatgtcgg tggacggggc gtctcctaat aaacctgata ccaagaagac   1380

aacttgagcc acttggatcc cgaagtgggc ttcccgggaa acctcgagca gagcaggcta   1440

cacaatcccc catcctcaag tccccaccgc ctcttcttcc tcactgtccc cgccccctat   1500

ttgtggacta aagatgaact ctggtgtgca tgctattatt gctgcaatta gaatattatc   1560

acacacaaag gtctctatat taacgctggt tttataagtg accgtatatt gtaaagagct   1620

gttaaaaagt attatagacc tattcatgta ttatttcaca tgttttgact ctggcttgca   1680

gcaccattcg gagtaaggat gacagcaggc ccagaaggtg tcttactcag aaaaaaaaat   1740

gcctggtcag caattcactg tcatgcacct atttttagat tgggcaggga gatgggagga   1800

gtcgtgattt ttactttgaa tactatttca ctgacgttac taagcattgc agcacaatgt   1860

agaaattggc ttgggatgga taggtatagg gaagggcatt cgttgggaaa ttgatgaccg   1920

gaaactagaa agcccctata atgtggaata tgcatatgtg gggtgaaacc gtatactact   1980

ttcactgcca tgacactagg caaaaaatat ttcctgttaa aagaaagaga aaaagagagg   2040

gatattgaaa aatataagga gttgagtcgc tttgtggtat agaagggagt aaggaataaa   2100

agatatagaa tagtaatcta gttgaactgt tctgcacaaa acatgcttcc ttttcaaaga   2160

atagacttca aaagggacga acaaacatta ggtcaccttt tgtgtttata atgaattgtt   2220

gacgtttcca tgctgtggtc tcttgatata cggaagtaga cgtaacttat tttccagcga   2280

aattatatac ttcttctggg ctcctttgct cagttgcccc aggaaggctt ccctgtgagt   2340

aatgcttatg gaatctgaca aatgtgaatg agctgccatt ggtgggaatc agtaaacttt   2400

gaaaaccttt cactgatgat tccctggtaa gtgctcctgt gaggggccac ttccctagta   2460

tgtgagagag accctctgca agccgctgtg gggacttagc ttcctgatac taggtagtga   2520

tggtggatct agagacattc acttgaagag caaggattgg ggtggggtgg gttggtgaat   2580

ctatctcagg ccactgcact gcaaggtgca tttctgtcat ttctgcaaca ccatgagacc   2640

tgagcaagaa tgtgctgtgg cagagggggt cttggtttca taaatgggta tatacagcct   2700

gaactcagga ggcagaaatc aaaagaaatc cttgagggct ggaacctgag gatagagcga   2760

aaatggagag aagggtgttc aaggtcagga gtgatttttg catttggtgg aaaacctcaa   2820

gtcagactca gtggcagaac atgcagcaga aaagctgtga aggaaggaaa tttacgtgat   2880

tgtaatggag gctaggggtg gattgggagg tgagtggagg agagtctctg accagctgca   2940

gagccaaccc ctatcatttt attaacatgg aacccacaca gataggggag ggattaagct   3000

aagaacttac agaatgcaaa cacgagcaca ctctcttcga acccaattgt gggtgtagca   3060

atgaaagcaa tatgatatgc tgcagtgtga agctccttct ggggttatcg tatgtacaaa   3120

gtttacctta taatggctca aattgtattt aatttttttg ttttgtttat aaatgaagaa   3180

aagctataag tataatgtaa ttattttata ggtatactat taaattatag aacaaataaa   3240

gataatctag gattatatgt gatcccggtg tgacgtgcca taaaagtgga atttttgact   3300

tgttgcagtg agctgtgaag cagcactatg cgttcagaga gtttttgttc aaccatggtg   3360

agttcaacct ctagcttatg tcacatgatc tcctttgggg tctggaatct tctaagagaa   3420

atagaatcag gcatccaagg agcagaagtg atggaggtgg ccctcaatcc tggtctttgg   3480

aagcttccaa gcctcttcca catcccctgc cagctgaaga cagagtattc tcactgtgct   3540

ggctgaagga gaaacactaa acaaggaaac cttgagaaac tgcagcaatg gaagtccact   3600

gttagtctct ccgttagcac cagggacaca cttgttctga gttttgttca ttttcacatt   3660

tactcctcat gagttccaac atttcttaat ttaaatattt cttagtttat agcatctcca   3720

tttttctatt aattgactta atctgccatt taagaaaact ccgtaatcaa taaaaaataa   3780

aatccacaat caaactgcac atggttgatc cactgtgtag gcttcaaagg aattaaactc   3840

aacttcctag gaaataattc atcttagttt attaaatggg acagaatatt tcactgctaa   3900

cgtattctaa ctcacttgtt tttgaaattg gccagatgat ttttaagtta taaagtcaat   3960

gaaaatgact tttgctattg tgtgaacaac ttagaatgta tatattccca gaaggcttat   4020

ttaatgattg acctatcacc actgattatt aatgtctgca tgaatgataa caataagacc   4080

aagtcatcaa taatgcaatg aaaatttttt aagtgaaagc aagtttatta agaaagtaaa   4140

ggaataaaga atgcctactt cataggcaga gcagcct                            4177


<210>  7542
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  7542

Met Phe Trp Lys Leu Ser Leu Ser Leu Phe Leu Val Ala Val Leu Val 
1               5                   10                  15      


Lys Val Ala Glu Ala Arg Lys Asn Arg Pro Ala Gly Ala Ile Pro Ser 
            20                  25                  30          


Pro Tyr Lys Asp Gly Ser Ser Asn Asn Ser Glu Arg Trp Gln His Gln 
        35                  40                  45              


Ile Lys Glu Val Leu Ala Ser Ser Gln Glu Ala Leu Val Val Thr Glu 
    50                  55                  60                  


Arg Lys Tyr Leu Lys Ser Asp Trp Cys Lys Thr Gln Pro Leu Arg Gln 
65                  70                  75                  80  


Thr Val Ser Glu Glu Gly Cys Arg Ser Arg Thr Ile Leu Asn Arg Phe 
                85                  90                  95      


Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro Arg His Val Lys Lys 
            100                 105                 110         


Glu Glu Glu Ser Phe Gln Ser Cys Ala Phe Cys Lys Pro Gln Arg Val 
        115                 120                 125             


Thr Ser Val Leu Val Glu Leu Glu Cys Pro Gly Leu Asp Pro Pro Phe 
    130                 135                 140                 


Arg Leu Lys Lys Ile Gln Lys Val Lys Gln Cys Arg Cys Met Ser Val 
145                 150                 155                 160 


Asn Leu Ser Asp Ser Asp Lys Gln 
                165             


<210>  7543
<211>  3261
<212>  DNA
<213>  Homosapiens

<400>  7543
ttcagagcta agtctccggg ctcctttcac atctgcagga gcagccagcc tgggaccgcg     60

cggcgcgggg cgcgctctcg cctctcctgc accctcagcc ggcgcgcttc tcttatgggc    120

gtctgctgca gtctggctgc ggtcgaactg aaagcggcgg cgggagacca aacttagacc    180

ccgctgtgga ctagagaact cagagaaggc agagggagag ggagagagag agagagaagg    240

gacccgagga ggaggcttcc atcacgtcat tgcaggatgt tctggaagct ttccctgtcc    300

ttgttcctgg tggcggtgct ggtgaaggtg gcggaagccc ggaagaaccg gccggcgggc    360

gccatcccct cgccttacaa ggacggcagc agcaacaact cggagagatg gcagcaccag    420

atcaaggagg tgctggcctc cagccaggag gccctggtgg tcaccgagcg caagtacctc    480

aagagtgact ggtgcaagac gcagccgctg cggcagacgg tgagcgagga gggctgccgg    540

agccgcacca tcctcaaccg cttctgctac ggccagtgca actccttcta catcccgcgg    600

cacgtgaaga aggaggagga gtccttccag tcctgcgcct tctgcaagcc ccagcgcgtc    660

acctccgtcc tcgtggagct cgagtgcccc ggcctggacc cacccttccg actcaagaaa    720

atccagaagg tgaagcagtg ccggtgcatg tccgtgaacc tgagcgactc ggacaagcag    780

tgagcgccgg gccggacgca gctcagcccc gcgcgcgccc ggccgctggg tggcgccgcc    840

gccgcctctg tccctgccct ccgagcccac tgtcacgctg cctggtgttc cccctcagca    900

gcaagcactt ctcttagggc tgacggtgtc cttgtcacag acgtggatcg caagtggagc    960

ttttgctgat gtgttcctga ccgaccccgg gtcccacctg tgccccctaa accaggcggt   1020

ggatcaggcc cgaaggaaaa tgctggaaaa ccaccaccgc cacccagcag tcagagagga   1080

cctttcgagg tgatgcactg taaatccggc attgatgttt ccaccatgtg gaaaagcaag   1140

gatttccctg gccccgccct gcactccagc tcgccccttt cccgcgcgaa gtgaaggatg   1200

cgtcactttt ctgagcggcc cctcagacct ctcctgctgg tccctggacc tctggctggg   1260

agcgctcatt cttgtgactg gcaggctgcc ctcggtcgct gctgtgatga ggatatgtgc   1320

aacctccata aatatgtcgg tggacggggc gtctcctaat aaacctgata ccaagaagac   1380

aacttgagcc acttggatcc cgaagtgggc ttcccgggaa acctcgagca gagcaggcta   1440

cacaatcccc catcctcaag tccccaccgc ctcttcttcc tcactgtccc cgccccctat   1500

ttgtggacta aagatgaact ctggtgtgca tgctattatt gctgcaatta gaatattatc   1560

acacacaaag gtctctatat taacgctggt tttataagtg accgtatatt gtaaagagct   1620

gttaaaaagt attatagacc tattcatgta ttatttcaca tgttttgact ctggcttgca   1680

gcaccattcg gagtaaggat gacagcaggc ccagaaggtg tcttactcag aaaaaaaaat   1740

gcctggtcag caattcactg tcatgcacct atttttagat tgggcaggga gatgggagga   1800

gtcgtgattt ttactttgaa tactatttca ctgacgttac taagcattgc agcacaatgt   1860

agaaattggc ttgggatgga taggtatagg gaagggcatt cgttgggaaa ttgatgaccg   1920

gaaactagaa agcccctata atgtggaata tgcatatgtg gggtgaaacc gtatactact   1980

ttcactgcca tgacactagg caaaaaatat ttcctgttaa aagaaagaga aaaagagagg   2040

gatattgaaa aatataagga gttgagtcgc tttgtggtat agaagggagt aaggaataaa   2100

agatatagaa tagtaatcta gttgaactgt tctgcacaaa acatgcttcc ttttcaaaga   2160

atagacttca aaagggacga acaaacatta ggtcaccttt tgtgtttata atgaattgtt   2220

gacgtttcca tgctgtggtc tcttgatata cggaagtaga cgtaacttat tttccagcga   2280

aattatatac ttcttctggg ctcctttgct cagttgcccc aggaaggctt ccctgtgagt   2340

aatgcttatg gaatctgaca aatgtgaatg agctgccatt ggtgggaatc agtaaacttt   2400

gaaaaccttt cactgatgat tccctggtaa gtgctcctgt gaggggccac ttccctagta   2460

tgtgagagag accctctgca agccgctgtg gggacttagc ttcctgatac taggtagtga   2520

tggtggatct agagacattc acttgaagag caaggattgg ggtggggtgg gttggtgaat   2580

ctatctcagg ccactgcact gcaaggtgca tttctgtcat ttctgcaaca ccatgagacc   2640

tgagcaagaa tgtgctgtgg cagagggggt cttggtttca taaatgggta tatacagcct   2700

gaactcagga ggcagaaatc aaaagaaatc cttgagggct ggaacctgag gatagagcga   2760

aaatggagag aagggtgttc aaggtcagga gtgatttttg catttggtgg aaaacctcaa   2820

gtcagactca gtggcagaac atgcagcaga aaagctgtga aggaaggaaa tttacgtgat   2880

tgtaatggag gctaggggtg gattgggagg tgagtggagg agagtctctg accagctgca   2940

gagccaaccc ctatcatttt attaacatgg aacccacaca gataggggag ggattaagct   3000

aagaacttac agaatgcaaa cacgagcaca ctctcttcga acccaattgt gggtgtagca   3060

atgaaagcaa tatgatatgc tgcagtgtga agctccttct ggggttatcg tatgtacaaa   3120

gtttacctta taatggctca aattgtattt aatttttttg ttttgtttat aaatgaagaa   3180

aagctataag tataatgtaa ttattttata ggtatactat taaattatag aacaaataaa   3240

gataatctag gattatatgt g                                             3261


<210>  7544
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  7544

Met Phe Trp Lys Leu Ser Leu Ser Leu Phe Leu Val Ala Val Leu Val 
1               5                   10                  15      


Lys Val Ala Glu Ala Arg Lys Asn Arg Pro Ala Gly Ala Ile Pro Ser 
            20                  25                  30          


Pro Tyr Lys Asp Gly Ser Ser Asn Asn Ser Glu Arg Trp Gln His Gln 
        35                  40                  45              


Ile Lys Glu Val Leu Ala Ser Ser Gln Glu Ala Leu Val Val Thr Glu 
    50                  55                  60                  


Arg Lys Tyr Leu Lys Ser Asp Trp Cys Lys Thr Gln Pro Leu Arg Gln 
65                  70                  75                  80  


Thr Val Ser Glu Glu Gly Cys Arg Ser Arg Thr Ile Leu Asn Arg Phe 
                85                  90                  95      


Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro Arg His Val Lys Lys 
            100                 105                 110         


Glu Glu Glu Ser Phe Gln Ser Cys Ala Phe Cys Lys Pro Gln Arg Val 
        115                 120                 125             


Thr Ser Val Leu Val Glu Leu Glu Cys Pro Gly Leu Asp Pro Pro Phe 
    130                 135                 140                 


Arg Leu Lys Lys Ile Gln Lys Val Lys Gln Cys Arg Cys Met Ser Val 
145                 150                 155                 160 


Asn Leu Ser Asp Ser Asp Lys Gln 
                165             


<210>  7545
<211>  987
<212>  DNA
<213>  Homosapiens

<400>  7545
atgggccatc agaatcacac tttcagcagt gatttcatac ttttgggatt gttctcttct     60

tccccaacaa gtgtggtctt cttcttagtt ttatttgtca ttttcattat gagtgtaaca    120

gaaaatacgc tcatgatcct cctcattcgc agtgactccc gactccacac tccaatgtat    180

tttctgctca gccatctctc cttaatggat atcttgcatg tttccaacat cgttcccaaa    240

atggtcacta actttctgtc aggcagcaga actatttcat ttgcaggttg tgggttccag    300

gtatttctgt ccctcaccct cctgggtggt gagtgccttc tcctggctgc aatgtcctgt    360

gatcgctatg tggctatctg tcacccgctg cgctatccga ttcttatgaa ggagtatgcc    420

agcgctctca tggctggagg ctcctggctc attggggttt tcaactccac agtccacaca    480

gcttatgcac tgcagtttcc cttctgtggc tctagggcaa ttgatcactt cttctgtgaa    540

gtccctgcca tgttgaagtt gtcctgtgca gacacaacac gctatgaacg aggggtttgt    600

gtaagtgctg tgatcttcct gctgatccct ttctccttga tctctgcttc ttatggccaa    660

attattctta ctgtcctcca gatgaaatca tcagaggcaa ggaaaaagtc attttccact    720

tgttccttcc acatgattgt ggtcacgatg tactatgggc catttatttt tacatatatg    780

agacctaaat cataccacac tccaggccag gataagttcc tggcaatatt ctatacgatc    840

ctcacaccca cactcaaccc tttcatctac agctttagga ataaagatgt tctggcggtg    900

atgaaaaata tgctcaaaag taactttctg cacaaaaaaa tgaataggaa aattcctgaa    960

tgtgtgttct gtctatttct atgttaa                                        987


<210>  7546
<211>  328
<212>  PRT
<213>  Homosapiens

<400>  7546

Met Gly His Gln Asn His Thr Phe Ser Ser Asp Phe Ile Leu Leu Gly 
1               5                   10                  15      


Leu Phe Ser Ser Ser Pro Thr Ser Val Val Phe Phe Leu Val Leu Phe 
            20                  25                  30          


Val Ile Phe Ile Met Ser Val Thr Glu Asn Thr Leu Met Ile Leu Leu 
        35                  40                  45              


Ile Arg Ser Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser 
    50                  55                  60                  


His Leu Ser Leu Met Asp Ile Leu His Val Ser Asn Ile Val Pro Lys 
65                  70                  75                  80  


Met Val Thr Asn Phe Leu Ser Gly Ser Arg Thr Ile Ser Phe Ala Gly 
                85                  90                  95      


Cys Gly Phe Gln Val Phe Leu Ser Leu Thr Leu Leu Gly Gly Glu Cys 
            100                 105                 110         


Leu Leu Leu Ala Ala Met Ser Cys Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Leu Met Lys Glu Tyr Ala Ser Ala Leu Met 
    130                 135                 140                 


Ala Gly Gly Ser Trp Leu Ile Gly Val Phe Asn Ser Thr Val His Thr 
145                 150                 155                 160 


Ala Tyr Ala Leu Gln Phe Pro Phe Cys Gly Ser Arg Ala Ile Asp His 
                165                 170                 175     


Phe Phe Cys Glu Val Pro Ala Met Leu Lys Leu Ser Cys Ala Asp Thr 
            180                 185                 190         


Thr Arg Tyr Glu Arg Gly Val Cys Val Ser Ala Val Ile Phe Leu Leu 
        195                 200                 205             


Ile Pro Phe Ser Leu Ile Ser Ala Ser Tyr Gly Gln Ile Ile Leu Thr 
    210                 215                 220                 


Val Leu Gln Met Lys Ser Ser Glu Ala Arg Lys Lys Ser Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Phe His Met Ile Val Val Thr Met Tyr Tyr Gly Pro Phe Ile 
                245                 250                 255     


Phe Thr Tyr Met Arg Pro Lys Ser Tyr His Thr Pro Gly Gln Asp Lys 
            260                 265                 270         


Phe Leu Ala Ile Phe Tyr Thr Ile Leu Thr Pro Thr Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Phe Arg Asn Lys Asp Val Leu Ala Val Met Lys Asn Met 
    290                 295                 300                 


Leu Lys Ser Asn Phe Leu His Lys Lys Met Asn Arg Lys Ile Pro Glu 
305                 310                 315                 320 


Cys Val Phe Cys Leu Phe Leu Cys 
                325             


<210>  7547
<211>  969
<212>  DNA
<213>  Homosapiens

<400>  7547
atgaattgcc acaaaagttt aaaggacata tccagctacc agcgacctac aacggaatgt     60

tcaaaagact atgtgtatct ccaccacaat acccaggggg cctctcgtct gatacctcgg    120

tctggaaggc gtgcccagct gcccttccgc aggagacacc agtgtgtaga gcagagccct    180

tcctttcgag agggtcttca cgctctcatc gtggtcggcg gtcgcgggag aggggccctc    240

ctggacccgc aagcacgccc actactgcca aagacgccgc ggctggtctc gcagcagcgc    300

gtcctccggc agccccagcg agtgagcccg gggctcggat ttctgcacga gaaccggctg    360

acccacgcac acctgaaaac cgagaacatc ctgcatgtgg attctgagtt aaacaccgtc    420

tacagcgagc acaggagcga tgagaagtca gtgaggagca ccagcgtccg agtggctgac    480

ttccccaatg ccacctctga cctactacca ggtttcacac tcttccagac ctgtgaaaac    540

caagagcgcc tggtgatgtt gaagacccta cggctcatcc cattacgcgt gatctcctgt    600

accaagaagc agaaatattt ctacaaatgg ggcctagttt gggatgagaa cagctctgac    660

agcccatatg tgaagaactg caaacgtctg aagagtgaca tgctccaaga ctctctggag    720

cacgtgcagc tgtttgacct gatgcggagg gtggtaaaat tggacgctgc ccagcacatc    780

actctggctg agactcttct gcaccccgtc tttgctggcc tggcaacctc agtcgtggtc    840

cttccacaca agccacaacc caagcagatg acagacgcag gacactgcat gaggagagcg    900

gaactgggct gcccaatccc cattctccag cccctaccac caggtcccag gaccagaacc    960

acacaatga                                                            969


<210>  7548
<211>  322
<212>  PRT
<213>  Homosapiens

<400>  7548

Met Asn Cys His Lys Ser Leu Lys Asp Ile Ser Ser Tyr Gln Arg Pro 
1               5                   10                  15      


Thr Thr Glu Cys Ser Lys Asp Tyr Val Tyr Leu His His Asn Thr Gln 
            20                  25                  30          


Gly Ala Ser Arg Leu Ile Pro Arg Ser Gly Arg Arg Ala Gln Leu Pro 
        35                  40                  45              


Phe Arg Arg Arg His Gln Cys Val Glu Gln Ser Pro Ser Phe Arg Glu 
    50                  55                  60                  


Gly Leu His Ala Leu Ile Val Val Gly Gly Arg Gly Arg Gly Ala Leu 
65                  70                  75                  80  


Leu Asp Pro Gln Ala Arg Pro Leu Leu Pro Lys Thr Pro Arg Leu Val 
                85                  90                  95      


Ser Gln Gln Arg Val Leu Arg Gln Pro Gln Arg Val Ser Pro Gly Leu 
            100                 105                 110         


Gly Phe Leu His Glu Asn Arg Leu Thr His Ala His Leu Lys Thr Glu 
        115                 120                 125             


Asn Ile Leu His Val Asp Ser Glu Leu Asn Thr Val Tyr Ser Glu His 
    130                 135                 140                 


Arg Ser Asp Glu Lys Ser Val Arg Ser Thr Ser Val Arg Val Ala Asp 
145                 150                 155                 160 


Phe Pro Asn Ala Thr Ser Asp Leu Leu Pro Gly Phe Thr Leu Phe Gln 
                165                 170                 175     


Thr Cys Glu Asn Gln Glu Arg Leu Val Met Leu Lys Thr Leu Arg Leu 
            180                 185                 190         


Ile Pro Leu Arg Val Ile Ser Cys Thr Lys Lys Gln Lys Tyr Phe Tyr 
        195                 200                 205             


Lys Trp Gly Leu Val Trp Asp Glu Asn Ser Ser Asp Ser Pro Tyr Val 
    210                 215                 220                 


Lys Asn Cys Lys Arg Leu Lys Ser Asp Met Leu Gln Asp Ser Leu Glu 
225                 230                 235                 240 


His Val Gln Leu Phe Asp Leu Met Arg Arg Val Val Lys Leu Asp Ala 
                245                 250                 255     


Ala Gln His Ile Thr Leu Ala Glu Thr Leu Leu His Pro Val Phe Ala 
            260                 265                 270         


Gly Leu Ala Thr Ser Val Val Val Leu Pro His Lys Pro Gln Pro Lys 
        275                 280                 285             


Gln Met Thr Asp Ala Gly His Cys Met Arg Arg Ala Glu Leu Gly Cys 
    290                 295                 300                 


Pro Ile Pro Ile Leu Gln Pro Leu Pro Pro Gly Pro Arg Thr Arg Thr 
305                 310                 315                 320 


Thr Gln 
        


<210>  7549
<211>  1994
<212>  DNA
<213>  Homosapiens

<400>  7549
cggccaccag gtggcgcctg tttatcatct tccgcacctg cgccctgggc tcactcgctg     60

gggctgccgg aggacgcgct ccttcaggac ccgctgcggc caccaggtgg agcctcttta    120

tcatcttccg cacccgagcc ccgggctcac tcgctggggc tgccggagga cgcgctgctg    180

cgagaccagc cgcggcgtct ttggcagtag tgggcgtgct tgcgggtcca ggagggcccc    240

tctcccgcga ccgccgacca cgatgagagc gtgaagaccc tctcgaaagg aagggctctg    300

ctctacacac tggtgtctcc tgcggaaggg cagctgggca cgccttccag accgagttac    360

agcagaaagt tttcatggag aaatggaatc acacttcaaa tgatttcatt ttgttgggtc    420

tgcttccccc aaatcaaact ggaatatttc tcttgtgcct tatcatcctc atattctttc    480

tggcctcggt gggtaactcg gccatgattc acctcatcca cgtggatcct cgtctccaca    540

caccgatgta ctttcttctc agccagctct cccttatgga cctgatgtac atctccacca    600

ccgtccccaa gatggcgtac aacttcctgt ccggccagaa aggcatctcc ttcctgggat    660

gtggtgtgca aagcttcttc ttcctgacca tggcgtgttc tgaaggctta ctcctgacct    720

ccatggccta cgaccgttat ttggccatct gccactctct ctattatcct atccgcatga    780

gtaaaatgat gtgtgtgaag atgattggag gctcttggac actggggtcc atcaactcct    840

tggcacacac agtctttgcc cttcatattc cctactgcag gtctagggct attgaccatt    900

tcttctgcga tgtcccagcc atgttgcttc ttgcctgtac agatacttgg gtctatgaat    960

atatggtttt tgtaagtaca agcctctttc tccttttccc tttcattggc atcacttctt   1020

cctgtggccg agtcctattt gctgtctatc atatgcactc aaaggagggg agaaaaaagg   1080

ccttcaccac catttcaaca catttaactg tagtgatctt ttactatgca ccttttgtct   1140

acacctatct tcggcccagg aatctccgct caccagctga agacaagatc ctggcagtct   1200

tctacaccat ccttaccccc atgctcaatc ccattatcta cagcctgagg aataaggaag   1260

tcctgggggc tatgaggaga gtgtttggga tattctcttt cctgaaagaa taatcatggc   1320

catccccact ccctttgtat ttcctctttc caagttgatt ccaacacgct agagcagggt   1380

tgtccaatag aaatacaaca taatttaaaa ttttctaata ggtacattta agcagtcaaa   1440

taaatttaaa taatatattt aattcaaaac aatgttataa ttaatattaa tattaacaat   1500

attgatgtta attacatagc atactatttc aataaattat atgcaatata ttatagtaca   1560

tgtttgtaca tatattacta ttaacgtgat aatgtttatt cttgtatatt gacatagaat   1620

ttcttcatgt aataacacaa atttgttaat gttgcctttt actctgtttg cattctaagt   1680

cttcaaagtc ttgtgtttgt tttatagagt gcagcgcagc ttggacaaaa cacatttcaa   1740

gtgcccagta gtcagtgtct atagtgttgg acagcacatt cttagagcat ccccaatcaa   1800

tagtttcaga agttatatat gcatgtgtat gtgcatgtat ggtgtataca aacatatttt   1860

tgttatatac aatattgctg atgaactgaa aattaacaag taaaatgcac atgctaaggt   1920

agtgtttatg tgtttcttta tctgttggct catttttagc atatgcacat ttattgtaat   1980

taacatttga agtc                                                     1994


<210>  7550
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  7550

Met Glu Lys Trp Asn His Thr Ser Asn Asp Phe Ile Leu Leu Gly Leu 
1               5                   10                  15      


Leu Pro Pro Asn Gln Thr Gly Ile Phe Leu Leu Cys Leu Ile Ile Leu 
            20                  25                  30          


Ile Phe Phe Leu Ala Ser Val Gly Asn Ser Ala Met Ile His Leu Ile 
        35                  40                  45              


His Val Asp Pro Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 
    50                  55                  60                  


Leu Ser Leu Met Asp Leu Met Tyr Ile Ser Thr Thr Val Pro Lys Met 
65                  70                  75                  80  


Ala Tyr Asn Phe Leu Ser Gly Gln Lys Gly Ile Ser Phe Leu Gly Cys 
                85                  90                  95      


Gly Val Gln Ser Phe Phe Phe Leu Thr Met Ala Cys Ser Glu Gly Leu 
            100                 105                 110         


Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys His Ser 
        115                 120                 125             


Leu Tyr Tyr Pro Ile Arg Met Ser Lys Met Met Cys Val Lys Met Ile 
    130                 135                 140                 


Gly Gly Ser Trp Thr Leu Gly Ser Ile Asn Ser Leu Ala His Thr Val 
145                 150                 155                 160 


Phe Ala Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asp His Phe 
                165                 170                 175     


Phe Cys Asp Val Pro Ala Met Leu Leu Leu Ala Cys Thr Asp Thr Trp 
            180                 185                 190         


Val Tyr Glu Tyr Met Val Phe Val Ser Thr Ser Leu Phe Leu Leu Phe 
        195                 200                 205             


Pro Phe Ile Gly Ile Thr Ser Ser Cys Gly Arg Val Leu Phe Ala Val 
    210                 215                 220                 


Tyr His Met His Ser Lys Glu Gly Arg Lys Lys Ala Phe Thr Thr Ile 
225                 230                 235                 240 


Ser Thr His Leu Thr Val Val Ile Phe Tyr Tyr Ala Pro Phe Val Tyr 
                245                 250                 255     


Thr Tyr Leu Arg Pro Arg Asn Leu Arg Ser Pro Ala Glu Asp Lys Ile 
            260                 265                 270         


Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Leu Gly Ala Met Arg Arg Val Phe 
    290                 295                 300                 


Gly Ile Phe Ser Phe Leu Lys Glu 
305                 310         


<210>  7551
<211>  1883
<212>  DNA
<213>  Homosapiens

<400>  7551
ccggaggacg cgctgctgcg agaccagccg cggcgtcttt ggcagtagtg ggcgtgcttg     60

cgggtccagg agggcccctc tcccgcgacc gccgaccacg atgagagcgt gaagaccctc    120

tcgaaaggaa gggctctgct ctacacactg gtgtctcctg cggaagggca gctgggcacg    180

ccttccagac cgagcaaaag ttgaaaaatc agtaacccaa gatgactaac caaatcaata    240

tgctgggcag gatgagacat cagtgtctgc ctcagacaga agagcacaca caaaacatga    300

cctctcactc caagcccagt tacagcagaa agttttcatg gagaaatgga atcacacttc    360

aaatgatttc attttgttgg gtctgcttcc cccaaatcaa actggaatat ttctcttgtg    420

ccttatcatc ctcatattct ttctggcctc ggtgggtaac tcggccatga ttcacctcat    480

ccacgtggat cctcgtctcc acacaccgat gtactttctt ctcagccagc tctcccttat    540

ggacctgatg tacatctcca ccaccgtccc caagatggcg tacaacttcc tgtccggcca    600

gaaaggcatc tccttcctgg gatgtggtgt gcaaagcttc ttcttcctga ccatggcgtg    660

ttctgaaggc ttactcctga cctccatggc ctacgaccgt tatttggcca tctgccactc    720

tctctattat cctatccgca tgagtaaaat gatgtgtgtg aagatgattg gaggctcttg    780

gacactgggg tccatcaact ccttggcaca cacagtcttt gcccttcata ttccctactg    840

caggtctagg gctattgacc atttcttctg cgatgtccca gccatgttgc ttcttgcctg    900

tacagatact tgggtctatg aatatatggt ttttgtaagt acaagcctct ttctcctttt    960

ccctttcatt ggcatcactt cttcctgtgg ccgagtccta tttgctgtct atcatatgca   1020

ctcaaaggag gggagaaaaa aggccttcac caccatttca acacatttaa ctgtagtgat   1080

cttttactat gcaccttttg tctacaccta tcttcggccc aggaatctcc gctcaccagc   1140

tgaagacaag atcctggcag tcttctacac catccttacc cccatgctca atcccattat   1200

ctacagcctg aggaataagg aagtcctggg ggctatgagg agagtgtttg ggatattctc   1260

tttcctgaaa gaataatcat ggccatcccc actccctttg tatttcctct ttccaagttg   1320

attccaacac gctagagcag ggttgtccaa tagaaataca acataattta aaattttcta   1380

ataggtacat ttaagcagtc aaataaattt aaataatata tttaattcaa aacaatgtta   1440

taattaatat taatattaac aatattgatg ttaattacat agcatactat ttcaataaat   1500

tatatgcaat atattatagt acatgtttgt acatatatta ctattaacgt gataatgttt   1560

attcttgtat attgacatag aatttcttca tgtaataaca caaatttgtt aatgttgcct   1620

tttactctgt ttgcattcta agtcttcaaa gtcttgtgtt tgttttatag agtgcagcgc   1680

agcttggaca aaacacattt caagtgccca gtagtcagtg tctatagtgt tggacagcac   1740

attcttagag catccccaat caatagtttc agaagttata tatgcatgtg tatgtgcatg   1800

tatggtgtat acaaacatat ttttgttata tacaatattg ctgatgaact gaaaattaac   1860

aagtaaaatg cacatgctaa ggt                                           1883


<210>  7552
<211>  82
<212>  PRT
<213>  Homosapiens

<400>  7552

Met Thr Asn Gln Ile Asn Met Leu Gly Arg Met Arg His Gln Cys Leu 
1               5                   10                  15      


Pro Gln Thr Glu Glu His Thr Gln Asn Met Thr Ser His Ser Lys Pro 
            20                  25                  30          


Ser Tyr Ser Arg Lys Phe Ser Trp Arg Asn Gly Ile Thr Leu Gln Met 
        35                  40                  45              


Ile Ser Phe Cys Trp Val Cys Phe Pro Gln Ile Lys Leu Glu Tyr Phe 
    50                  55                  60                  


Ser Cys Ala Leu Ser Ser Ser Tyr Ser Phe Trp Pro Arg Trp Val Thr 
65                  70                  75                  80  


Arg Pro 
        


<210>  7553
<211>  1957
<212>  DNA
<213>  Homosapiens

<400>  7553
ccggaggacg cgctgctgcg agaccagccg cggcgtcttt ggcagtagtg ggcgtgcttg     60

cgggtccagg agggcccctc tcccgcgacc gccgaccacg atgagagcgt gaagaccctc    120

tcgaaaggaa gggctctgct ctacacactg gtgtctcctg cggaagggca gctgggcacg    180

ccttccagac cgagcaaaag ttgaaaaatc agtaacccaa gatgactaac caaatcaata    240

tgctgggcag gatgagacat cagtgtctgc ctcagacaga agagcacaca caaaacatga    300

cctctcactc caagcccagt tacagcagaa agttttcatg gagaaatgga atcacacttc    360

aaatgatttc attttgttgg gtctgcttcc cccaaatcaa actggaatat ttctcttgtg    420

ccttatcatc ctcatattct ttctggcctc ggtgggtaac tcggccatga ttcacctcat    480

ccacgtggat cctcgtctcc acacaccgat gtactttctt ctcagccagc tctcccttat    540

ggacctgatg tacatctcca ccaccgtccc caagatggcg tacaacttcc tgtccggcca    600

gaaaggcatc tccttcctgg gatgtggtgt gcaaagcttc ttcttcctga ccatggcgtg    660

ttctgaaggc ttactcctga cctccatggc ctacgaccgt tatttggcca tctgccactc    720

tctctattat cctatccgca tgagtaaaat gatgtgtgtg aagatgattg gaggctcttg    780

gacactgggg tccatcaact ccttggcaca cacagtcttt gcccttcata ttccctactg    840

caggtctagg gctattgacc atttcttctg cgatgtccca gccatgttgc ttcttgcctg    900

tacagatact tgggtctatg aatatatggt ttttgtaagt acaagcctct ttctcctttt    960

ccctttcatt ggcatcactt cttcctgtgg ccgagtccta tttgctgtct atcatatgca   1020

ctcaaaggag gggagaaaaa aggccttcac caccatttca acacatttaa ctgtagtgat   1080

cttttactat gcaccttttg tctacaccta tcttcggccc aggaatctcc gctcaccagc   1140

tgaagacaag atcctggcag tcttctacac catccttacc cccatgctca atcccattat   1200

ctacagcctg aggaataagg aagtcctggg ggctatgagg agagtgtttg ggatattctc   1260

tttcctgaaa gaataatcat ggccatcccc actccctttg tatttcctct ttccaagttg   1320

attccaacac gctagagcag ggttgtccaa tagaaataca acataattta aaattttcta   1380

ataggtacat ttaagcagtc aaataaattt aaataatata tttaattcaa aacaatgtta   1440

taattaatat taatattaac aatattgatg ttaattacat agcatactat ttcaataaat   1500

tatatgcaat atattatagt acatgtttgt acatatatta ctattaacgt gataatgttt   1560

attcttgtat attgacatag aatttcttca tgtaataaca caaatttgtt aatgttgcct   1620

tttactctgt ttgcattcta agtcttcaaa gtcttgtgtt tgttttatag agtgcagcgc   1680

agcttggaca aaacacattt caagtgccca gtagtcagtg tctatagtgt tggacagcac   1740

attcttagag catccccaat caatagtttc agaagttata tatgcatgtg tatgtgcatg   1800

tatggtgtat acaaacatat ttttgttata tacaatattg ctgatgaact gaaaattaac   1860

aagtaaaatg cacatgctaa ggtagtgttt atgtgtttct ttatctgttg gctcattttt   1920

agcatatgca catttattgt aattaacatt tgaagtc                            1957


<210>  7554
<211>  82
<212>  PRT
<213>  Homosapiens

<400>  7554

Met Thr Asn Gln Ile Asn Met Leu Gly Arg Met Arg His Gln Cys Leu 
1               5                   10                  15      


Pro Gln Thr Glu Glu His Thr Gln Asn Met Thr Ser His Ser Lys Pro 
            20                  25                  30          


Ser Tyr Ser Arg Lys Phe Ser Trp Arg Asn Gly Ile Thr Leu Gln Met 
        35                  40                  45              


Ile Ser Phe Cys Trp Val Cys Phe Pro Gln Ile Lys Leu Glu Tyr Phe 
    50                  55                  60                  


Ser Cys Ala Leu Ser Ser Ser Tyr Ser Phe Trp Pro Arg Trp Val Thr 
65                  70                  75                  80  


Arg Pro 
        


<210>  7555
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  7555
atggaaaatt acaatcaaac atcaactgat ttcatcttat tggggctgtt tccaccatca     60

agaattgacc ttttcttctt cattctcatt gttttcattt tcctgatggc tctaattgga    120

aacctgtcca tgattcttct catcttcttg gacacccatc tccacacacc catgtatttc    180

ctactgagtc agctctccct cattgaccta aattacatct ccaccattgt tcctaagatg    240

gcatctgatt ttctgcatgg aaacaagtct atctccttca ctgggtgtgg gattcagagt    300

ttcttcttct tggcattagg aggtgcagaa gcactacttt tggcatctat ggcctatgat    360

cgttacattg ctatttgctt tcctctccac tatctcatcc gcatgagcaa aagagtgtgt    420

gtgctgatga taacagggtc ttggatcata ggctcgatca atgcttgtgc tcacactgta    480

tatgtactcc atattcctta ttgccgatcc agggccatca atcatttctt ctgtgatgtc    540

ccagcaatgg tgactctggc ctgcatggac acctgggtct atgagggcac agtgtttttg    600

agtgccacca tctttctcgt gtttcccttc attggtattt catgttccta tggccaggtt    660

ctctttgctg tctaccacat gaaatctgca gaagggagga agaaagccta tttgacctgc    720

agcacccacc tcactgtagt aactttctac tatgcacctt ttgtctacac ttatctacgt    780

ccaagatccc tgcgatctcc aacagaggac aaggttctgg ctgtcttcta caccatcctc    840

accccaatgc tcaaccccat catctatagc ctgaggaaca aggaggtgat gggggccctg    900

acacgagtga gtcagagaat ctgctctgtg aaaatgtag                           939


<210>  7556
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  7556

Met Glu Asn Tyr Asn Gln Thr Ser Thr Asp Phe Ile Leu Leu Gly Leu 
1               5                   10                  15      


Phe Pro Pro Ser Arg Ile Asp Leu Phe Phe Phe Ile Leu Ile Val Phe 
            20                  25                  30          


Ile Phe Leu Met Ala Leu Ile Gly Asn Leu Ser Met Ile Leu Leu Ile 
        35                  40                  45              


Phe Leu Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 
    50                  55                  60                  


Leu Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met 
65                  70                  75                  80  


Ala Ser Asp Phe Leu His Gly Asn Lys Ser Ile Ser Phe Thr Gly Cys 
                85                  90                  95      


Gly Ile Gln Ser Phe Phe Phe Leu Ala Leu Gly Gly Ala Glu Ala Leu 
            100                 105                 110         


Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Phe Pro 
        115                 120                 125             


Leu His Tyr Leu Ile Arg Met Ser Lys Arg Val Cys Val Leu Met Ile 
    130                 135                 140                 


Thr Gly Ser Trp Ile Ile Gly Ser Ile Asn Ala Cys Ala His Thr Val 
145                 150                 155                 160 


Tyr Val Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asn His Phe 
                165                 170                 175     


Phe Cys Asp Val Pro Ala Met Val Thr Leu Ala Cys Met Asp Thr Trp 
            180                 185                 190         


Val Tyr Glu Gly Thr Val Phe Leu Ser Ala Thr Ile Phe Leu Val Phe 
        195                 200                 205             


Pro Phe Ile Gly Ile Ser Cys Ser Tyr Gly Gln Val Leu Phe Ala Val 
    210                 215                 220                 


Tyr His Met Lys Ser Ala Glu Gly Arg Lys Lys Ala Tyr Leu Thr Cys 
225                 230                 235                 240 


Ser Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Val Tyr 
                245                 250                 255     


Thr Tyr Leu Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Val 
            260                 265                 270         


Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Thr Arg Val Ser 
    290                 295                 300                 


Gln Arg Ile Cys Ser Val Lys Met 
305                 310         


<210>  7557
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  7557
atgaaaacag gaaatcaaag ttttgggaca gattttctac ttgttggtct tttccaatat     60

ggctggataa actctcttct ctttgtcgtc attgccaccc tctttacagt tgctctgaca    120

ggaaatatca tgctgatcca cctcattcga ctgaacacca gactccacac tccaatgtac    180

tttctgctca gtcagctctc catcgttgac ctcatgtaca tctccaccac agtgcccaag    240

atggcagtca gcttcctctc acagagtaag accattagat ttttgggctg tgagattcaa    300

acgtatgtgt tcttggccct tggtggaact gaagcccttc tccttggttt tatgtcttat    360

gatcgctatg tagctatctg tcacccttta cattatccta tgcttatgag caagaagatc    420

tgctgcctca tggttgcatg tgcatgggcc agtggttcta tcaatgcttt catacataca    480

ttgtatgtgt ttcagcttcc attctgtagg tctcggctca ttaaccactt tttctgtgaa    540

gttccagctc tactatcatt ggtgtgtcag gacacctccc agtatgagta tacagtcctc    600

ctgagtggac ttattatctt gctactacca ttcctagcca ttctggcttc ctatgctcgt    660

gtgcttattg tggtattcca gatgagctca ggaaaaggac aggcaaaagc tgtttccact    720

tgttcctccc acctgattgt ggcaagcctg ttctatgcaa ccactctctt tacctacaca    780

aggccacact ccttgcgttc cccttcacgg gataaggcgg tggcagtatt ttacaccatt    840

gtcacacctc tactgaaccc atttatctac agcctgagaa ataaggaagt gacgggggca    900

gtgaggagac tgttgggata ttggatatgc tgtagaaaat atgacttcag atctctgtat    960

tga                                                                  963


<210>  7558
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  7558

Met Lys Thr Gly Asn Gln Ser Phe Gly Thr Asp Phe Leu Leu Val Gly 
1               5                   10                  15      


Leu Phe Gln Tyr Gly Trp Ile Asn Ser Leu Leu Phe Val Val Ile Ala 
            20                  25                  30          


Thr Leu Phe Thr Val Ala Leu Thr Gly Asn Ile Met Leu Ile His Leu 
        35                  40                  45              


Ile Arg Leu Asn Thr Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser 
    50                  55                  60                  


Gln Leu Ser Ile Val Asp Leu Met Tyr Ile Ser Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Ala Val Ser Phe Leu Ser Gln Ser Lys Thr Ile Arg Phe Leu Gly 
                85                  90                  95      


Cys Glu Ile Gln Thr Tyr Val Phe Leu Ala Leu Gly Gly Thr Glu Ala 
            100                 105                 110         


Leu Leu Leu Gly Phe Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu His Tyr Pro Met Leu Met Ser Lys Lys Ile Cys Cys Leu Met 
    130                 135                 140                 


Val Ala Cys Ala Trp Ala Ser Gly Ser Ile Asn Ala Phe Ile His Thr 
145                 150                 155                 160 


Leu Tyr Val Phe Gln Leu Pro Phe Cys Arg Ser Arg Leu Ile Asn His 
                165                 170                 175     


Phe Phe Cys Glu Val Pro Ala Leu Leu Ser Leu Val Cys Gln Asp Thr 
            180                 185                 190         


Ser Gln Tyr Glu Tyr Thr Val Leu Leu Ser Gly Leu Ile Ile Leu Leu 
        195                 200                 205             


Leu Pro Phe Leu Ala Ile Leu Ala Ser Tyr Ala Arg Val Leu Ile Val 
    210                 215                 220                 


Val Phe Gln Met Ser Ser Gly Lys Gly Gln Ala Lys Ala Val Ser Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Ile Val Ala Ser Leu Phe Tyr Ala Thr Thr Leu 
                245                 250                 255     


Phe Thr Tyr Thr Arg Pro His Ser Leu Arg Ser Pro Ser Arg Asp Lys 
            260                 265                 270         


Ala Val Ala Val Phe Tyr Thr Ile Val Thr Pro Leu Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Thr Gly Ala Val Arg Arg Leu 
    290                 295                 300                 


Leu Gly Tyr Trp Ile Cys Cys Arg Lys Tyr Asp Phe Arg Ser Leu Tyr 
305                 310                 315                 320 


<210>  7559
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  7559
atggaaaatt acaatcaaac atcaactgat ttcatcttat tggggctgtt cccacaatca     60

agaattggcc ttttcgtatt caccctcatt tttctcattt tcctaatggc tctaattgga    120

aatctatcca tgattcttct catctttttg gacatccatc tccacacacc tatgtatttc    180

ctacttagtc agctctccct cattgaccta aattacatct ccaccattgt tccaaagatg    240

gtttatgatt ttctgtatgg aaacaagtct atctccttca ctggatgtgg gattcagagt    300

ttcttcttct tgactttagc agttgcagaa gggctgctcc tgacatcaat ggcctatgat    360

cgttatgtgg ccatttgctt tcctctccac tatcccatcc gtataagcaa aagagtgtgt    420

gtgatgatga taacaggatc ttggatgata agctctatca actcttgtgc tcacacagta    480

tatgcactct gtatcccata ttgcaagtcc agagccatca atcatttttt ctgtgatgtt    540

ccagctatgt tgacgctagc ctgcacagac acttgggtct atgagagcac agtgtttttg    600

agcagcacca tctttcttgt gcttcctttc actggtattg catgttccta tggccgggtt    660

ctccttgctg tctaccgcat gcactctgca gaagggagga agaaggccta ttcaacctgt    720

agcacccacc tcactgtagt gtccttctac tatgcaccct ttgcttatac ctatgtacgt    780

ccaagatccc tgcgatctcc aacagaggac aagattctgg ctgttttcta caccatcctc    840

accccaatgc tcaaccccat catctacagc ctgagaaaca aggaggtgat gggggccctg    900

acacaagtga ttcagaaaat cttctcagtg aaaatgtag                           939


<210>  7560
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  7560

Met Glu Asn Tyr Asn Gln Thr Ser Thr Asp Phe Ile Leu Leu Gly Leu 
1               5                   10                  15      


Phe Pro Gln Ser Arg Ile Gly Leu Phe Val Phe Thr Leu Ile Phe Leu 
            20                  25                  30          


Ile Phe Leu Met Ala Leu Ile Gly Asn Leu Ser Met Ile Leu Leu Ile 
        35                  40                  45              


Phe Leu Asp Ile His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 
    50                  55                  60                  


Leu Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met 
65                  70                  75                  80  


Val Tyr Asp Phe Leu Tyr Gly Asn Lys Ser Ile Ser Phe Thr Gly Cys 
                85                  90                  95      


Gly Ile Gln Ser Phe Phe Phe Leu Thr Leu Ala Val Ala Glu Gly Leu 
            100                 105                 110         


Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro 
        115                 120                 125             


Leu His Tyr Pro Ile Arg Ile Ser Lys Arg Val Cys Val Met Met Ile 
    130                 135                 140                 


Thr Gly Ser Trp Met Ile Ser Ser Ile Asn Ser Cys Ala His Thr Val 
145                 150                 155                 160 


Tyr Ala Leu Cys Ile Pro Tyr Cys Lys Ser Arg Ala Ile Asn His Phe 
                165                 170                 175     


Phe Cys Asp Val Pro Ala Met Leu Thr Leu Ala Cys Thr Asp Thr Trp 
            180                 185                 190         


Val Tyr Glu Ser Thr Val Phe Leu Ser Ser Thr Ile Phe Leu Val Leu 
        195                 200                 205             


Pro Phe Thr Gly Ile Ala Cys Ser Tyr Gly Arg Val Leu Leu Ala Val 
    210                 215                 220                 


Tyr Arg Met His Ser Ala Glu Gly Arg Lys Lys Ala Tyr Ser Thr Cys 
225                 230                 235                 240 


Ser Thr His Leu Thr Val Val Ser Phe Tyr Tyr Ala Pro Phe Ala Tyr 
                245                 250                 255     


Thr Tyr Val Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Ile 
            260                 265                 270         


Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Thr Gln Val Ile 
    290                 295                 300                 


Gln Lys Ile Phe Ser Val Lys Met 
305                 310         


<210>  7561
<211>  1080
<212>  DNA
<213>  Homosapiens

<400>  7561
atgctgtgga gagctgtcct tgtctatact ccagaagaca ctcttttgtg tcatctgatt     60

gacattctag acaagtgttg tcaatgtgaa ataattctta ctgtagacat gcagattcag    120

gaaagagcac acgaatgccc catggaaaat tacaatcaaa catcaactga tttcatctta    180

ttaggattct tcccaccatc aagaattggc cttttcctct tcatcctcat tgttttcatt    240

ttcctaatgg ctctaattgg aaacctatcc atgattcttc tcatcttctt ggacacccat    300

ctccacacac ccatgtattt cctacttagt cagctctccc tcattgacct aaattacatc    360

tccaccattg ttcctaagat ggcatctgat tttctgtctg gtaacaagtc tatctccttc    420

actgggtgtg ggattcagag tttcttcttc tcggcattag gaggtgcaga agcactactt    480

ttggcatcta tggcctatga tcgttacatt gctatttgct ttcctcttca ctatcccatc    540

cgcatgagca aaagaatgtg tgtgctgatg ataacagggt cttggatcat aggctcgatc    600

aatgcttgtg ctcacactgt atatgtactc catattcctt attgccaatc cagggccatc    660

aatcatttct tctgtgatgt cccagcaatg gtgactctgg cctgcatgga cacctgggtc    720

tatgagggca cagtgttttt gagcaccacc atctttctcg tgtttccctt cattgctatt    780

tcatgttcct atggccgggt tctccttgct gtctaccaca tgaaatctgc agaagggagg    840

aagaaagcct acctgacctg cagcacccac ctcactgtag taactttcta ctatgcacct    900

tttgtctaca cttatctacg tccaagatcc ctgcgatctc caacagagga caaggttctg    960

gctgtcttct acaccaccct cactccaatg ctcaacccca tcatctatag cctgaggaac   1020

aaggaggtga tgggggccct gacacgagtg agtcagagaa tctgctctgg gaaaatgtag   1080


<210>  7562
<211>  359
<212>  PRT
<213>  Homosapiens

<400>  7562

Met Leu Trp Arg Ala Val Leu Val Tyr Thr Pro Glu Asp Thr Leu Leu 
1               5                   10                  15      


Cys His Leu Ile Asp Ile Leu Asp Lys Cys Cys Gln Cys Glu Ile Ile 
            20                  25                  30          


Leu Thr Val Asp Met Gln Ile Gln Glu Arg Ala His Glu Cys Pro Met 
        35                  40                  45              


Glu Asn Tyr Asn Gln Thr Ser Thr Asp Phe Ile Leu Leu Gly Phe Phe 
    50                  55                  60                  


Pro Pro Ser Arg Ile Gly Leu Phe Leu Phe Ile Leu Ile Val Phe Ile 
65                  70                  75                  80  


Phe Leu Met Ala Leu Ile Gly Asn Leu Ser Met Ile Leu Leu Ile Phe 
                85                  90                  95      


Leu Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu 
            100                 105                 110         


Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met Ala 
        115                 120                 125             


Ser Asp Phe Leu Ser Gly Asn Lys Ser Ile Ser Phe Thr Gly Cys Gly 
    130                 135                 140                 


Ile Gln Ser Phe Phe Phe Ser Ala Leu Gly Gly Ala Glu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Phe Pro Leu 
                165                 170                 175     


His Tyr Pro Ile Arg Met Ser Lys Arg Met Cys Val Leu Met Ile Thr 
            180                 185                 190         


Gly Ser Trp Ile Ile Gly Ser Ile Asn Ala Cys Ala His Thr Val Tyr 
        195                 200                 205             


Val Leu His Ile Pro Tyr Cys Gln Ser Arg Ala Ile Asn His Phe Phe 
    210                 215                 220                 


Cys Asp Val Pro Ala Met Val Thr Leu Ala Cys Met Asp Thr Trp Val 
225                 230                 235                 240 


Tyr Glu Gly Thr Val Phe Leu Ser Thr Thr Ile Phe Leu Val Phe Pro 
                245                 250                 255     


Phe Ile Ala Ile Ser Cys Ser Tyr Gly Arg Val Leu Leu Ala Val Tyr 
            260                 265                 270         


His Met Lys Ser Ala Glu Gly Arg Lys Lys Ala Tyr Leu Thr Cys Ser 
        275                 280                 285             


Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Val Tyr Thr 
    290                 295                 300                 


Tyr Leu Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Val Leu 
305                 310                 315                 320 


Ala Val Phe Tyr Thr Thr Leu Thr Pro Met Leu Asn Pro Ile Ile Tyr 
                325                 330                 335     


Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Thr Arg Val Ser Gln 
            340                 345                 350         


Arg Ile Cys Ser Gly Lys Met 
        355                 


<210>  7563
<211>  834
<212>  DNA
<213>  Homosapiens

<400>  7563
atgggaaact ccctcatggt tctcctaatc tacctggata cccagctcca tacccccatg     60

tacttcctcc tcagtcaact gtcccccatg gacgtcaggc tcatctgcac caccgtaccc    120

aagatggcct tcaactactt gtctggcagc aagtccattt ctatggctgg ctgtgccaca    180

caaattttct tctgtgtatc actgcttggc tctgaatgct ttctgttggc tgttatgtct    240

tatgactgct acattgccat ttgccaccct ctaagataca ccaatctcat gagacccaaa    300

atttgtagac ttatgactgc cttctcctgg atcctgggct ctacagatgg aatcatttat    360

gctgtagcca cattttcctt ctcctactgt gggtctcggg aaatagccca cttcttctgt    420

gagttacctt ccctactaat cctctcatgc aatgacacat caatatttga aaaggttatt    480

ttcatttgct ctatagtaat gcttgttttc cctgttgcaa tcatcattgc ttcctatgct    540

ggagttattc tggctgtcat tcacatggga tctggagagg gtcgtcgcaa agctttcacg    600

acctgttcct ctcacctcat ggtggtggga atgttctatg gagcaggttt gttcatgtac    660

atacagccca catctgatcg ctccccaacg caggacaagc tggtgtctgt attctacacc    720

atcctcactc ccatgctgaa tcccctcatc tacagcctcc gcaacaagga agtgaccaga    780

gcattcatga agatctcagg aaagggcaag tctggagaga gagttacctc ataa          834


<210>  7564
<211>  277
<212>  PRT
<213>  Homosapiens

<400>  7564

Met Gly Asn Ser Leu Met Val Leu Leu Ile Tyr Leu Asp Thr Gln Leu 
1               5                   10                  15      


His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu Ser Pro Met Asp Val 
            20                  25                  30          


Arg Leu Ile Cys Thr Thr Val Pro Lys Met Ala Phe Asn Tyr Leu Ser 
        35                  40                  45              


Gly Ser Lys Ser Ile Ser Met Ala Gly Cys Ala Thr Gln Ile Phe Phe 
    50                  55                  60                  


Cys Val Ser Leu Leu Gly Ser Glu Cys Phe Leu Leu Ala Val Met Ser 
65                  70                  75                  80  


Tyr Asp Cys Tyr Ile Ala Ile Cys His Pro Leu Arg Tyr Thr Asn Leu 
                85                  90                  95      


Met Arg Pro Lys Ile Cys Arg Leu Met Thr Ala Phe Ser Trp Ile Leu 
            100                 105                 110         


Gly Ser Thr Asp Gly Ile Ile Tyr Ala Val Ala Thr Phe Ser Phe Ser 
        115                 120                 125             


Tyr Cys Gly Ser Arg Glu Ile Ala His Phe Phe Cys Glu Leu Pro Ser 
    130                 135                 140                 


Leu Leu Ile Leu Ser Cys Asn Asp Thr Ser Ile Phe Glu Lys Val Ile 
145                 150                 155                 160 


Phe Ile Cys Ser Ile Val Met Leu Val Phe Pro Val Ala Ile Ile Ile 
                165                 170                 175     


Ala Ser Tyr Ala Gly Val Ile Leu Ala Val Ile His Met Gly Ser Gly 
            180                 185                 190         


Glu Gly Arg Arg Lys Ala Phe Thr Thr Cys Ser Ser His Leu Met Val 
        195                 200                 205             


Val Gly Met Phe Tyr Gly Ala Gly Leu Phe Met Tyr Ile Gln Pro Thr 
    210                 215                 220                 


Ser Asp Arg Ser Pro Thr Gln Asp Lys Leu Val Ser Val Phe Tyr Thr 
225                 230                 235                 240 


Ile Leu Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys 
                245                 250                 255     


Glu Val Thr Arg Ala Phe Met Lys Ile Ser Gly Lys Gly Lys Ser Gly 
            260                 265                 270         


Glu Arg Val Thr Ser 
        275         


<210>  7565
<211>  906
<212>  DNA
<213>  Homosapiens

<400>  7565
atgccaggat ccctcggtga atacaggttt ttgcaagctt ttgacaatgg caaccactct     60

caggccctag caactgtggc cttcatggga aactctgtca tggttctcct catctacctg    120

gacacccagc tccacacccc catgtacttc ctcctcagtc aactgttcct catggacctc    180

atgctcatct gctctaccgt acccaagatg gccttcaact acttgtctgg cagcaagtcc    240

atttctatgg ctggttgtgc cacacaaatt ttcttctatg tatcactgct tggctccgaa    300

tgctttctgt tggctgttat gtcttatgac cgctatattg ccatttgcca ccctctaaga    360

tacaccaatc tcatgagacc caaaatttgt ggacttatga ctgccttctc ctggatcctg    420

ggctctatgg atgcaatcat tgatgctgta gcgacatttt ccttctccta ctgtgggtct    480

cgggaaatag cccacttctt ctgtgacttc ccttccctac taatcctctc atgcaatgac    540

acatcaatat ttgaaaaggt tcttttcatc tgctgtatag taatgattgt ttttcctgtt    600

gcaatcatca tcgcttccta tgctcgagtt attctggctg tcattcacat gggatctgga    660

gagggtcgtc gcaaagcttt tactacctgt tcctctcacc tcatggtggt gggaatgtac    720

tatggagcag gtttgttcat gtacatacgg cccacatctg atcgctcccc tatgcaggac    780

aagctggtgt ctgtattcta caccatcctc actcccatgc tgaatcccct catctacagc    840

ctccgcaaca aggaggtgac cagagcactc aggaaagtgt taggaaaggg caagtgtgga    900

gagtga                                                               906


<210>  7566
<211>  301
<212>  PRT
<213>  Homosapiens

<400>  7566

Met Pro Gly Ser Leu Gly Glu Tyr Arg Phe Leu Gln Ala Phe Asp Asn 
1               5                   10                  15      


Gly Asn His Ser Gln Ala Leu Ala Thr Val Ala Phe Met Gly Asn Ser 
            20                  25                  30          


Val Met Val Leu Leu Ile Tyr Leu Asp Thr Gln Leu His Thr Pro Met 
        35                  40                  45              


Tyr Phe Leu Leu Ser Gln Leu Phe Leu Met Asp Leu Met Leu Ile Cys 
    50                  55                  60                  


Ser Thr Val Pro Lys Met Ala Phe Asn Tyr Leu Ser Gly Ser Lys Ser 
65                  70                  75                  80  


Ile Ser Met Ala Gly Cys Ala Thr Gln Ile Phe Phe Tyr Val Ser Leu 
                85                  90                  95      


Leu Gly Ser Glu Cys Phe Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr 
            100                 105                 110         


Ile Ala Ile Cys His Pro Leu Arg Tyr Thr Asn Leu Met Arg Pro Lys 
        115                 120                 125             


Ile Cys Gly Leu Met Thr Ala Phe Ser Trp Ile Leu Gly Ser Met Asp 
    130                 135                 140                 


Ala Ile Ile Asp Ala Val Ala Thr Phe Ser Phe Ser Tyr Cys Gly Ser 
145                 150                 155                 160 


Arg Glu Ile Ala His Phe Phe Cys Asp Phe Pro Ser Leu Leu Ile Leu 
                165                 170                 175     


Ser Cys Asn Asp Thr Ser Ile Phe Glu Lys Val Leu Phe Ile Cys Cys 
            180                 185                 190         


Ile Val Met Ile Val Phe Pro Val Ala Ile Ile Ile Ala Ser Tyr Ala 
        195                 200                 205             


Arg Val Ile Leu Ala Val Ile His Met Gly Ser Gly Glu Gly Arg Arg 
    210                 215                 220                 


Lys Ala Phe Thr Thr Cys Ser Ser His Leu Met Val Val Gly Met Tyr 
225                 230                 235                 240 


Tyr Gly Ala Gly Leu Phe Met Tyr Ile Arg Pro Thr Ser Asp Arg Ser 
                245                 250                 255     


Pro Met Gln Asp Lys Leu Val Ser Val Phe Tyr Thr Ile Leu Thr Pro 
            260                 265                 270         


Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Thr Arg 
        275                 280                 285             


Ala Leu Arg Lys Val Leu Gly Lys Gly Lys Cys Gly Glu 
    290                 295                 300     


<210>  7567
<211>  2484
<212>  DNA
<213>  Homosapiens

<400>  7567
atggaggtag aaggacttca gaatacagag gctaaatacc atgacagcag tgaacttaca     60

gaaggagcta ctgctcagca tgtgactttc tgggccacag acactattga gcatgttaca    120

caggcctttg tttccatggc aacaggacta caggaaggtt atggccagac tgacatagac    180

agtgttctag tggacgcaat tgcggcggct ccagtcctca ggggactcca gtcctcaggg    240

ggctccagtc ctcagggggg tgctccagtc ctcagggggg cgttccagtc ctcaggtggc    300

tccagtcctc agggtgctcc agtcctcagg gggctcgagt cctcaggcgg ctccagtact    360

cagggggctc cagtcctcag ggggctccag tcctcagggc ggctccagtc ctcagggggc    420

tccagtcctc agtgtgctcc agtcttcagg cagctccagt cctcaggggg ctccagtcct    480

cggggggctc caatcctcgg ggggctccag tcctcagggc tgctccagtc ctcagggggc    540

tccagtcttc aggcggctcc agtcctcagg gtgctccagt cctcaggggg ctccagtcct    600

cagggggctc cattcctcag ggggctccag tcttcaggcg gctccagtcc tcagggtgct    660

ccagtcctca gggggctcca gtcttcaggc ggctccagtc ctcaggcggc tccagtcctc    720

agggggctcc agtcctcagg gggctccatt cctcaggggg ctccagtctt caggtggctc    780

cagtcctcag ggtgctccag tcctcagggg gctccagtcc tcagggcggc tccattcctc    840

agggggttcc agtcttcagg cggctccagt cctcagggtg ctccagtcct cagggggctc    900

cagtcctcag ggcggctcca gtcctcaggg ggctccagtc ctcagggggc tccagtcctc    960

agggtggctc cagtcctcag ggggctccag tcctcaggcg gctccagtcc tcagggggct   1020

ccagtcttca ggcggctcca gtcctcaggg ggctccattc ctcagggggc tccagtcctc   1080

agggggcttc agtcctcagg cggctccagt cctcaggcgg ctccagtcct caggggggct   1140

ccagtcttca agggtatcca gtcctcaggg gggctccagt cttcaggcgg ctccagtcct   1200

cagggggctc cagtcctcag ggtgctccag tcctcagggg tatccagtcc tcaggggggc   1260

tccagtcctc atggggcttc agttcttagg cggctccagt cctcaggggg ctccagtcct   1320

cagggggctc cagtcctcag gcggctccag tcctcagggg gctccagtcc tcaggagggc   1380

gctccagcac ccgtgactcg ccaggctccg tctgagaccc gtgctaggct cgctctgtcc   1440

ctgcgttccc tcgcctctct ctccagttgt ttttcccatt ctcacaccag cactgcacca   1500

agcccaccac acacgttcct cttctttctg gtcctgggca tctttttagt ggccttcatg   1560

ggaaactctg tcatggttct cctcatctac ctggacaccc agctccacac ccccatgtac   1620

ttcctcctca gccaactgtc cctcatggac ctcatgctca tctgcaccac cgtacccaag   1680

atggccttca actacctgtc tggcagcaag tccatttcta tggctggttg tgtcacacaa   1740

attttcttct atatatcact gtctggctct gaatgttttc ttttggctgt tatggcttat   1800

gaccgctata ttgctatttg ccaccctcta agatatacca atctcatgaa tcctaaaatt   1860

tgtggactta tggctacctt ctcctggatc ctgggctcta cagatggaat cattgatgct   1920

gtagccacat tttccttctc cttttgtggg tctcgggaaa tagcccactt cttctgtgaa   1980

ttcccttccc tactaatcct ctcatgcaat gacacatcaa tatttgaaga ggttattttc   2040

atctgctgta tagtaatgct tgttttccct gttgcaatca tcattgcttc ctatgctcga   2100

gttattctgg ctgtcattca catgggatct ggagagggtc gttgcaaagc tttcacgacc   2160

tgttcctctc acctcatggt ggtgggaatg tactatggag cagctttgtt catgtacata   2220

cggcccacat ctgatcactc cccaacgcag gacaagatgg tgtctgtatt ctacaccatc   2280

ctcactccca tgctgaatcc cctcatctac agcctccgca acaaggaggt gactagagca   2340

ttcatgaaga tcttaggaaa gggcaagtct gagagtgagt tacctcataa actttatgtt   2400

ttgctgtttg ctaaattctt ctttctaata tccatctttt tctatgatgt caaaatacta   2460

gcattgatta tgtacattgc ctaa                                          2484


<210>  7568
<211>  827
<212>  PRT
<213>  Homosapiens

<400>  7568

Met Glu Val Glu Gly Leu Gln Asn Thr Glu Ala Lys Tyr His Asp Ser 
1               5                   10                  15      


Ser Glu Leu Thr Glu Gly Ala Thr Ala Gln His Val Thr Phe Trp Ala 
            20                  25                  30          


Thr Asp Thr Ile Glu His Val Thr Gln Ala Phe Val Ser Met Ala Thr 
        35                  40                  45              


Gly Leu Gln Glu Gly Tyr Gly Gln Thr Asp Ile Asp Ser Val Leu Val 
    50                  55                  60                  


Asp Ala Ile Ala Ala Ala Pro Val Leu Arg Gly Leu Gln Ser Ser Gly 
65                  70                  75                  80  


Gly Ser Ser Pro Gln Gly Gly Ala Pro Val Leu Arg Gly Ala Phe Gln 
                85                  90                  95      


Ser Ser Gly Gly Ser Ser Pro Gln Gly Ala Pro Val Leu Arg Gly Leu 
            100                 105                 110         


Glu Ser Ser Gly Gly Ser Ser Thr Gln Gly Ala Pro Val Leu Arg Gly 
        115                 120                 125             


Leu Gln Ser Ser Gly Arg Leu Gln Ser Ser Gly Gly Ser Ser Pro Gln 
    130                 135                 140                 


Cys Ala Pro Val Phe Arg Gln Leu Gln Ser Ser Gly Gly Ser Ser Pro 
145                 150                 155                 160 


Arg Gly Ala Pro Ile Leu Gly Gly Leu Gln Ser Ser Gly Leu Leu Gln 
                165                 170                 175     


Ser Ser Gly Gly Ser Ser Leu Gln Ala Ala Pro Val Leu Arg Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Gly Ser Ser Pro Gln Gly Ala Pro Phe Leu Arg Gly 
        195                 200                 205             


Leu Gln Ser Ser Gly Gly Ser Ser Pro Gln Gly Ala Pro Val Leu Arg 
    210                 215                 220                 


Gly Leu Gln Ser Ser Gly Gly Ser Ser Pro Gln Ala Ala Pro Val Leu 
225                 230                 235                 240 


Arg Gly Leu Gln Ser Ser Gly Gly Ser Ile Pro Gln Gly Ala Pro Val 
                245                 250                 255     


Phe Arg Trp Leu Gln Ser Ser Gly Cys Ser Ser Pro Gln Gly Ala Pro 
            260                 265                 270         


Val Leu Arg Ala Ala Pro Phe Leu Arg Gly Phe Gln Ser Ser Gly Gly 
        275                 280                 285             


Ser Ser Pro Gln Gly Ala Pro Val Leu Arg Gly Leu Gln Ser Ser Gly 
    290                 295                 300                 


Arg Leu Gln Ser Ser Gly Gly Ser Ser Pro Gln Gly Ala Pro Val Leu 
305                 310                 315                 320 


Arg Val Ala Pro Val Leu Arg Gly Leu Gln Ser Ser Gly Gly Ser Ser 
                325                 330                 335     


Pro Gln Gly Ala Pro Val Phe Arg Arg Leu Gln Ser Ser Gly Gly Ser 
            340                 345                 350         


Ile Pro Gln Gly Ala Pro Val Leu Arg Gly Leu Gln Ser Ser Gly Gly 
        355                 360                 365             


Ser Ser Pro Gln Ala Ala Pro Val Leu Arg Gly Ala Pro Val Phe Lys 
    370                 375                 380                 


Gly Ile Gln Ser Ser Gly Gly Leu Gln Ser Ser Gly Gly Ser Ser Pro 
385                 390                 395                 400 


Gln Gly Ala Pro Val Leu Arg Val Leu Gln Ser Ser Gly Val Ser Ser 
                405                 410                 415     


Pro Gln Gly Gly Ser Ser Pro His Gly Ala Ser Val Leu Arg Arg Leu 
            420                 425                 430         


Gln Ser Ser Gly Gly Ser Ser Pro Gln Gly Ala Pro Val Leu Arg Arg 
        435                 440                 445             


Leu Gln Ser Ser Gly Gly Ser Ser Pro Gln Glu Gly Ala Pro Ala Pro 
    450                 455                 460                 


Val Thr Arg Gln Ala Pro Ser Glu Thr Arg Ala Arg Leu Ala Leu Ser 
465                 470                 475                 480 


Leu Arg Ser Leu Ala Ser Leu Ser Ser Cys Phe Ser His Ser His Thr 
                485                 490                 495     


Ser Thr Ala Pro Ser Pro Pro His Thr Phe Leu Phe Phe Leu Val Leu 
            500                 505                 510         


Gly Ile Phe Leu Val Ala Phe Met Gly Asn Ser Val Met Val Leu Leu 
        515                 520                 525             


Ile Tyr Leu Asp Thr Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 
    530                 535                 540                 


Gln Leu Ser Leu Met Asp Leu Met Leu Ile Cys Thr Thr Val Pro Lys 
545                 550                 555                 560 


Met Ala Phe Asn Tyr Leu Ser Gly Ser Lys Ser Ile Ser Met Ala Gly 
                565                 570                 575     


Cys Val Thr Gln Ile Phe Phe Tyr Ile Ser Leu Ser Gly Ser Glu Cys 
            580                 585                 590         


Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys His 
        595                 600                 605             


Pro Leu Arg Tyr Thr Asn Leu Met Asn Pro Lys Ile Cys Gly Leu Met 
    610                 615                 620                 


Ala Thr Phe Ser Trp Ile Leu Gly Ser Thr Asp Gly Ile Ile Asp Ala 
625                 630                 635                 640 


Val Ala Thr Phe Ser Phe Ser Phe Cys Gly Ser Arg Glu Ile Ala His 
                645                 650                 655     


Phe Phe Cys Glu Phe Pro Ser Leu Leu Ile Leu Ser Cys Asn Asp Thr 
            660                 665                 670         


Ser Ile Phe Glu Glu Val Ile Phe Ile Cys Cys Ile Val Met Leu Val 
        675                 680                 685             


Phe Pro Val Ala Ile Ile Ile Ala Ser Tyr Ala Arg Val Ile Leu Ala 
    690                 695                 700                 


Val Ile His Met Gly Ser Gly Glu Gly Arg Cys Lys Ala Phe Thr Thr 
705                 710                 715                 720 


Cys Ser Ser His Leu Met Val Val Gly Met Tyr Tyr Gly Ala Ala Leu 
                725                 730                 735     


Phe Met Tyr Ile Arg Pro Thr Ser Asp His Ser Pro Thr Gln Asp Lys 
            740                 745                 750         


Met Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu 
        755                 760                 765             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Thr Arg Ala Phe Met Lys Ile 
    770                 775                 780                 


Leu Gly Lys Gly Lys Ser Glu Ser Glu Leu Pro His Lys Leu Tyr Val 
785                 790                 795                 800 


Leu Leu Phe Ala Lys Phe Phe Phe Leu Ile Ser Ile Phe Phe Tyr Asp 
                805                 810                 815     


Val Lys Ile Leu Ala Leu Ile Met Tyr Ile Ala 
            820                 825         


<210>  7569
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  7569
atggcaaggg agaattcgac cttcaactcc gacttcatcc tcctgggaat cttcaatcac     60

agccccaccc acaccttcct cttctttctg gtcctggcca tcttttcagt ggccttcatg    120

ggaaactctg tcatggttct cctcatctac ctggacaccc agctccacac ccccatgtac    180

ctcctcctca gccaactgtc cctcatggac ctcatgctca tctgcaccac cgtacccaag    240

atggccttca actacctgtc tggcagcaag tccatttcta tggctggttg tgccacacaa    300

attttcttct atacatcact gcttggctct gagtgctttc ttttggctgt tatggcttat    360

gaccgctaca ctgccatttg ccaccctcta agatacacca atctcatgag ccctaaaatt    420

tgtggactta tgactgcctt ttcctggatc ctgggctcta cggatggaat tattgatgtt    480

gtagcaacat tttccttctc ctactgtggg tctcgggaaa tagcccactt cttctgtgac    540

ttcccctccc tactaatcct ctcatgcagt gacacatcaa tatttgaaaa gattcttttc    600

atctgctgta tagtaatgat tgttttccct gttgcaatca tcattgcttc ctatgctcga    660

gttatcctgg ctgtcattca catgggatct ggagagggtc gtcgcaaagc ttttactact    720

tgttcctctc acctcttggt ggtgggaatg tactatggag cagctttgtt catgtacata    780

cggcccacat ctgatcgctc cccaacacag gacaagatgg tgtctgtatt ctacaccatc    840

ctcactccca tgttgaatcc cctcatctac agcctccgca acaaggaggt gaccagagca    900

ttcatgaaga tcttaggaaa gggcaagtct ggagagtga                           939


<210>  7570
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  7570

Met Ala Arg Glu Asn Ser Thr Phe Asn Ser Asp Phe Ile Leu Leu Gly 
1               5                   10                  15      


Ile Phe Asn His Ser Pro Thr His Thr Phe Leu Phe Phe Leu Val Leu 
            20                  25                  30          


Ala Ile Phe Ser Val Ala Phe Met Gly Asn Ser Val Met Val Leu Leu 
        35                  40                  45              


Ile Tyr Leu Asp Thr Gln Leu His Thr Pro Met Tyr Leu Leu Leu Ser 
    50                  55                  60                  


Gln Leu Ser Leu Met Asp Leu Met Leu Ile Cys Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Ala Phe Asn Tyr Leu Ser Gly Ser Lys Ser Ile Ser Met Ala Gly 
                85                  90                  95      


Cys Ala Thr Gln Ile Phe Phe Tyr Thr Ser Leu Leu Gly Ser Glu Cys 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Thr Asn Leu Met Ser Pro Lys Ile Cys Gly Leu Met 
    130                 135                 140                 


Thr Ala Phe Ser Trp Ile Leu Gly Ser Thr Asp Gly Ile Ile Asp Val 
145                 150                 155                 160 


Val Ala Thr Phe Ser Phe Ser Tyr Cys Gly Ser Arg Glu Ile Ala His 
                165                 170                 175     


Phe Phe Cys Asp Phe Pro Ser Leu Leu Ile Leu Ser Cys Ser Asp Thr 
            180                 185                 190         


Ser Ile Phe Glu Lys Ile Leu Phe Ile Cys Cys Ile Val Met Ile Val 
        195                 200                 205             


Phe Pro Val Ala Ile Ile Ile Ala Ser Tyr Ala Arg Val Ile Leu Ala 
    210                 215                 220                 


Val Ile His Met Gly Ser Gly Glu Gly Arg Arg Lys Ala Phe Thr Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Leu Val Val Gly Met Tyr Tyr Gly Ala Ala Leu 
                245                 250                 255     


Phe Met Tyr Ile Arg Pro Thr Ser Asp Arg Ser Pro Thr Gln Asp Lys 
            260                 265                 270         


Met Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Thr Arg Ala Phe Met Lys Ile 
    290                 295                 300                 


Leu Gly Lys Gly Lys Ser Gly Glu 
305                 310         


<210>  7571
<211>  936
<212>  DNA
<213>  Homosapiens

<400>  7571
atggtgtggg aaaaccagac cttcaactcc atcttcatcc tgctgggaat cttcaatcac     60

agtcccaccc acaccttcct tttttctctg gtcctgggca tcttctcact ggcattgatg    120

gaaaatattt ccatggttct cctcatctac atagagaaac agctccacac ccccatgtac    180

ttcctcctca gtcaactgtc ccttatggac ctcatgctca tctgcaccac tctacccaag    240

atgatcttca gctacttgtc tgggaagaaa tctatctctc tggcaggttg tggaactcag    300

atattcttct atgtgtccct gcttggagct gaatgtttct tgttggctgt catggcttat    360

gaccgctatg tggctatatg tcaccctctt cagtacacca tcctcatgaa tccgaaactc    420

tgtgtcttca tgactgttgc ttcctggacc ttggggtctc ttgatgggat catagtgctt    480

gcagctgtcc tgtcattttc ttactgcagc tctctggaaa ttcatcactt tttctgtgat    540

gttgctgccc ttttacctct atcctgcaca gaaacatctg catttgaaag actacttgtc    600

atttgttgtg tggtaatgct aatctttcca gtttcagtta tcatactttc ctattcccat    660

gtccttcgag ccgtcatcca catgggctct ggggaaagtc gtcgcaaggc cttcactacc    720

tgctcctccc acctgtctgt ggtcggactc tactacggtg ctgctatgtt catgtacatg    780

agaccagctt ctaaacatac gccagaccag gacaagatgg tgtcggcctt ctacactatt    840

ctcaccccta tgctgaaccc tctcatttat agcctccgca acaaagaagt gttcagggca    900

ctacagaagg tactgaagaa aagaaagtta atatga                              936


<210>  7572
<211>  311
<212>  PRT
<213>  Homosapiens

<400>  7572

Met Val Trp Glu Asn Gln Thr Phe Asn Ser Ile Phe Ile Leu Leu Gly 
1               5                   10                  15      


Ile Phe Asn His Ser Pro Thr His Thr Phe Leu Phe Ser Leu Val Leu 
            20                  25                  30          


Gly Ile Phe Ser Leu Ala Leu Met Glu Asn Ile Ser Met Val Leu Leu 
        35                  40                  45              


Ile Tyr Ile Glu Lys Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 
    50                  55                  60                  


Gln Leu Ser Leu Met Asp Leu Met Leu Ile Cys Thr Thr Leu Pro Lys 
65                  70                  75                  80  


Met Ile Phe Ser Tyr Leu Ser Gly Lys Lys Ser Ile Ser Leu Ala Gly 
                85                  90                  95      


Cys Gly Thr Gln Ile Phe Phe Tyr Val Ser Leu Leu Gly Ala Glu Cys 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Gln Tyr Thr Ile Leu Met Asn Pro Lys Leu Cys Val Phe Met 
    130                 135                 140                 


Thr Val Ala Ser Trp Thr Leu Gly Ser Leu Asp Gly Ile Ile Val Leu 
145                 150                 155                 160 


Ala Ala Val Leu Ser Phe Ser Tyr Cys Ser Ser Leu Glu Ile His His 
                165                 170                 175     


Phe Phe Cys Asp Val Ala Ala Leu Leu Pro Leu Ser Cys Thr Glu Thr 
            180                 185                 190         


Ser Ala Phe Glu Arg Leu Leu Val Ile Cys Cys Val Val Met Leu Ile 
        195                 200                 205             


Phe Pro Val Ser Val Ile Ile Leu Ser Tyr Ser His Val Leu Arg Ala 
    210                 215                 220                 


Val Ile His Met Gly Ser Gly Glu Ser Arg Arg Lys Ala Phe Thr Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Ser Val Val Gly Leu Tyr Tyr Gly Ala Ala Met 
                245                 250                 255     


Phe Met Tyr Met Arg Pro Ala Ser Lys His Thr Pro Asp Gln Asp Lys 
            260                 265                 270         


Met Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Phe Arg Ala Leu Gln Lys Val 
    290                 295                 300                 


Leu Lys Lys Arg Lys Leu Ile 
305                 310     


<210>  7573
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  7573
atggagatga gaaatactac cccagatttt attctcctag gactctttaa ccacaccaga     60

gcccaccaag tcctcttcat gatggttctg agtatcgttt tgacctccct gtttggcaat    120

tccctcatga ttctcctgat tcactgggac caccggctcc acacgcccat gtacttcctc    180

ctgagccaac tttccctcat ggacatgatg ctggtttcca ccactgtgcc caaaatggcg    240

gctgactact tgaccggaag taaggccatc tcccgcgctg gctgtggtgt gcagatcttc    300

ttcctcccca cactgggtgg tggagagtgc ttcctcttag cagccatggc ctatgaccgc    360

tatgcggctg tctgccaccc actccgatat cccactctca tgagctggca gctgtgcctg    420

aggatgacca tgtcgtgttg gctcctgggt gcagctgacg ggctcctgca ggctgttgtt    480

accctgagct tcccatattg tggtgcacac gagatcgatc acttcttctg cgagaccccc    540

gtgctggtgc gtttggcttg tgctgacact tcagtcttcg aaaacgccat gtacatctgc    600

tgtgtgttaa tgctcctggt ccccttttcc ctcatcctgt cctcctatgg tctcatcctc    660

gctgctgttc tgcacatgcg ctctacagaa gcccgcaaga aggcctttgc cacctgctct    720

tcacatgtgg ctgtggtggg actcttttat ggagctgcca tttttaccta tatgagaccc    780

aaatcccata ggtccactaa ccatgacaag gttgtgtcag ccttctatac tatgttcacc    840

cctttactaa accccctcat ctacagtgtg aagaacagtg aggtgaaggg agccctgaaa    900

cggtggctgg ggacgtgtgt aaacataaaa caccagcaaa atgaggccca caggtcaaga    960

tga                                                                  963


<210>  7574
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  7574

Met Glu Met Arg Asn Thr Thr Pro Asp Phe Ile Leu Leu Gly Leu Phe 
1               5                   10                  15      


Asn His Thr Arg Ala His Gln Val Leu Phe Met Met Val Leu Ser Ile 
            20                  25                  30          


Val Leu Thr Ser Leu Phe Gly Asn Ser Leu Met Ile Leu Leu Ile His 
        35                  40                  45              


Trp Asp His Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu 
    50                  55                  60                  


Ser Leu Met Asp Met Met Leu Val Ser Thr Thr Val Pro Lys Met Ala 
65                  70                  75                  80  


Ala Asp Tyr Leu Thr Gly Ser Lys Ala Ile Ser Arg Ala Gly Cys Gly 
                85                  90                  95      


Val Gln Ile Phe Phe Leu Pro Thr Leu Gly Gly Gly Glu Cys Phe Leu 
            100                 105                 110         


Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys His Pro Leu 
        115                 120                 125             


Arg Tyr Pro Thr Leu Met Ser Trp Gln Leu Cys Leu Arg Met Thr Met 
    130                 135                 140                 


Ser Cys Trp Leu Leu Gly Ala Ala Asp Gly Leu Leu Gln Ala Val Val 
145                 150                 155                 160 


Thr Leu Ser Phe Pro Tyr Cys Gly Ala His Glu Ile Asp His Phe Phe 
                165                 170                 175     


Cys Glu Thr Pro Val Leu Val Arg Leu Ala Cys Ala Asp Thr Ser Val 
            180                 185                 190         


Phe Glu Asn Ala Met Tyr Ile Cys Cys Val Leu Met Leu Leu Val Pro 
        195                 200                 205             


Phe Ser Leu Ile Leu Ser Ser Tyr Gly Leu Ile Leu Ala Ala Val Leu 
    210                 215                 220                 


His Met Arg Ser Thr Glu Ala Arg Lys Lys Ala Phe Ala Thr Cys Ser 
225                 230                 235                 240 


Ser His Val Ala Val Val Gly Leu Phe Tyr Gly Ala Ala Ile Phe Thr 
                245                 250                 255     


Tyr Met Arg Pro Lys Ser His Arg Ser Thr Asn His Asp Lys Val Val 
            260                 265                 270         


Ser Ala Phe Tyr Thr Met Phe Thr Pro Leu Leu Asn Pro Leu Ile Tyr 
        275                 280                 285             


Ser Val Lys Asn Ser Glu Val Lys Gly Ala Leu Lys Arg Trp Leu Gly 
    290                 295                 300                 


Thr Cys Val Asn Ile Lys His Gln Gln Asn Glu Ala His Arg Ser Arg 
305                 310                 315                 320 


<210>  7575
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  7575
atggagatga gaaatactac cccagatttt attctcctag gactctttaa ccacaccaga     60

gcccaccaag tcctcttcat gatgcttctg gccaccgttt tgacctccct gtttagcaat    120

gccctcatga ttctcctgat tcactgggac caccggctcc acaggcccat gtacttcctc    180

ctgagccaac tttccctcat ggacatgatg ctggtttcca ccactgtgcc caaaatggcg    240

gctgactact tgaccggaaa taaggccatc tcccgcgctg gctgtggtgt gcagatcttc    300

ttcctcccca cactgggtgg tggagagtgc ttcctcttag cagccatggc ctatgaccgc    360

tatgcggctg tctgccaccc actccgatat cccactctca tgagctggca gctgtgcctg    420

aggatgacca tgtcgtcctg gctcctgggt gcagctgacg gcctcctgca ggctgttgct    480

accctgagct tcccatattg cggtgcacac gagatcgatc acttcttctg cgaggccccc    540

gtgttggtgc gtttggcttg tgctgacact tcagtcttcg aaaacgccat gtacatctgc    600

tgtgtgttaa tgctcctggt ccccttttcc ctcatcctgt cctcctatgg tctcatcctc    660

gctgctgttc tgctcatgcg ctctacagaa gcccgcaaga aggcctttgc cacctgctct    720

tcacatgtgg ctgtggtggg actcttttat ggagctggca tttttaccta tatgagaccc    780

aaatcccaca ggtccactaa ccacgataag gttgtgtcag ccttctatac tatgttcacc    840

cctttactaa atcccctcat ctacagtgtg aggaacagtg aggtcaagga agccctgaaa    900

cggtggctgg ggacgtgtgt aaacctaaaa caccagcaaa atgaggccca caggtcaaga    960

tga                                                                  963


<210>  7576
<211>  320
<212>  PRT
<213>  Homosapiens

<400>  7576

Met Glu Met Arg Asn Thr Thr Pro Asp Phe Ile Leu Leu Gly Leu Phe 
1               5                   10                  15      


Asn His Thr Arg Ala His Gln Val Leu Phe Met Met Leu Leu Ala Thr 
            20                  25                  30          


Val Leu Thr Ser Leu Phe Ser Asn Ala Leu Met Ile Leu Leu Ile His 
        35                  40                  45              


Trp Asp His Arg Leu His Arg Pro Met Tyr Phe Leu Leu Ser Gln Leu 
    50                  55                  60                  


Ser Leu Met Asp Met Met Leu Val Ser Thr Thr Val Pro Lys Met Ala 
65                  70                  75                  80  


Ala Asp Tyr Leu Thr Gly Asn Lys Ala Ile Ser Arg Ala Gly Cys Gly 
                85                  90                  95      


Val Gln Ile Phe Phe Leu Pro Thr Leu Gly Gly Gly Glu Cys Phe Leu 
            100                 105                 110         


Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys His Pro Leu 
        115                 120                 125             


Arg Tyr Pro Thr Leu Met Ser Trp Gln Leu Cys Leu Arg Met Thr Met 
    130                 135                 140                 


Ser Ser Trp Leu Leu Gly Ala Ala Asp Gly Leu Leu Gln Ala Val Ala 
145                 150                 155                 160 


Thr Leu Ser Phe Pro Tyr Cys Gly Ala His Glu Ile Asp His Phe Phe 
                165                 170                 175     


Cys Glu Ala Pro Val Leu Val Arg Leu Ala Cys Ala Asp Thr Ser Val 
            180                 185                 190         


Phe Glu Asn Ala Met Tyr Ile Cys Cys Val Leu Met Leu Leu Val Pro 
        195                 200                 205             


Phe Ser Leu Ile Leu Ser Ser Tyr Gly Leu Ile Leu Ala Ala Val Leu 
    210                 215                 220                 


Leu Met Arg Ser Thr Glu Ala Arg Lys Lys Ala Phe Ala Thr Cys Ser 
225                 230                 235                 240 


Ser His Val Ala Val Val Gly Leu Phe Tyr Gly Ala Gly Ile Phe Thr 
                245                 250                 255     


Tyr Met Arg Pro Lys Ser His Arg Ser Thr Asn His Asp Lys Val Val 
            260                 265                 270         


Ser Ala Phe Tyr Thr Met Phe Thr Pro Leu Leu Asn Pro Leu Ile Tyr 
        275                 280                 285             


Ser Val Arg Asn Ser Glu Val Lys Glu Ala Leu Lys Arg Trp Leu Gly 
    290                 295                 300                 


Thr Cys Val Asn Leu Lys His Gln Gln Asn Glu Ala His Arg Ser Arg 
305                 310                 315                 320 


<210>  7577
<211>  939
<212>  DNA
<213>  Homosapiens

<400>  7577
atggcatggg agaatcagac cttcaactct gacttcctcc tcctgggaat cttcaatcat     60

agccccaccc acaccttcct cttctttctg gtcctggcca tcttttcagt ggccttcatg    120

ggaaactcca tcatggttct cctcatctac ctggataccc agctccacac ccccatgtac    180

ttcctcctca gccaactgtc cctcatggac ctcatgctca tctgcaccac tgtacccaag    240

atggccttca actacttgtc tggcagcaag tccatttcta tggctggctg tgccacacaa    300

attttcttct atatatcatt gcttggctcc gaatgctttc tgttggctgt tatgtcttat    360

gaccgctaca ctgccatttg ccaccctcta agatacacca atctcatgag acccaaaatt    420

tgtggactta tgactgcctt ctcctggatc ctgggctcta cagatggaat cattgatgct    480

gtagcgacat tttccttctc ctactgtggg tctcgggaaa tagcccactt ctgctgtgac    540

ttcccttccc tactaatcct ctcatgcaat gacacatcaa tatttgaaga ggttattttc    600

atctgctgta tagtaatgct tgttttccct gttgcaatca tcatcacttc ctatgctcga    660

gttattctgg ctgtcattca catgggatct ggagagggac gtcgcaaagc ttttactact    720

tgttcctctc acctcatggt ggtgggaatg tactatggag caggtttgtt catgtgcatt    780

cagcccacat ctcatcattc tcctatgcag gacaagatgg tgtctgtatt ctacaccatc    840

gtcactccca tgctgaatcc tctcatttat agcctccgca acaaggaagt gaccagagca    900

ttaatgaaaa tcttaggaaa gggcaagtct ggagattga                           939


<210>  7578
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  7578

Met Ala Trp Glu Asn Gln Thr Phe Asn Ser Asp Phe Leu Leu Leu Gly 
1               5                   10                  15      


Ile Phe Asn His Ser Pro Thr His Thr Phe Leu Phe Phe Leu Val Leu 
            20                  25                  30          


Ala Ile Phe Ser Val Ala Phe Met Gly Asn Ser Ile Met Val Leu Leu 
        35                  40                  45              


Ile Tyr Leu Asp Thr Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 
    50                  55                  60                  


Gln Leu Ser Leu Met Asp Leu Met Leu Ile Cys Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Ala Phe Asn Tyr Leu Ser Gly Ser Lys Ser Ile Ser Met Ala Gly 
                85                  90                  95      


Cys Ala Thr Gln Ile Phe Phe Tyr Ile Ser Leu Leu Gly Ser Glu Cys 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Thr Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Thr Asn Leu Met Arg Pro Lys Ile Cys Gly Leu Met 
    130                 135                 140                 


Thr Ala Phe Ser Trp Ile Leu Gly Ser Thr Asp Gly Ile Ile Asp Ala 
145                 150                 155                 160 


Val Ala Thr Phe Ser Phe Ser Tyr Cys Gly Ser Arg Glu Ile Ala His 
                165                 170                 175     


Phe Cys Cys Asp Phe Pro Ser Leu Leu Ile Leu Ser Cys Asn Asp Thr 
            180                 185                 190         


Ser Ile Phe Glu Glu Val Ile Phe Ile Cys Cys Ile Val Met Leu Val 
        195                 200                 205             


Phe Pro Val Ala Ile Ile Ile Thr Ser Tyr Ala Arg Val Ile Leu Ala 
    210                 215                 220                 


Val Ile His Met Gly Ser Gly Glu Gly Arg Arg Lys Ala Phe Thr Thr 
225                 230                 235                 240 


Cys Ser Ser His Leu Met Val Val Gly Met Tyr Tyr Gly Ala Gly Leu 
                245                 250                 255     


Phe Met Cys Ile Gln Pro Thr Ser His His Ser Pro Met Gln Asp Lys 
            260                 265                 270         


Met Val Ser Val Phe Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Thr Arg Ala Leu Met Lys Ile 
    290                 295                 300                 


Leu Gly Lys Gly Lys Ser Gly Asp 
305                 310         


<210>  7579
<211>  4208
<212>  DNA
<213>  Homosapiens

<400>  7579
agtattctgt aaggacattt gtgtttatat atatctgtca tatgtatata tatatcatat     60

atatatcagt catatatata tctcacacat atatgtaagt gattttatgc tatgtatctt    120

tttttcttct gatatctttt tctggtttca atgttagttt aatgctagct tcatcaaata    180

agttgggaag tggtctttta ctcatatttt gaaagaattt gtgtagaatt actataaatt    240

gttaaggaga atttttgtag aatttgctag tgaatatatt tatgttttga attttctttt    300

gtggaaggtt tttactacaa attccactta cttagtagaa ttaagattat tcaagttatc    360

taatttttta ctgagtaatt ctggtctcat tatgtctttc aagggaattt ttttcatttt    420

ttaatatcat tttatagctt tatattaaaa gttctgaata tgagtggctc tctgcctgct    480

ccctttcacc accttaatat cttaagtgaa taatgcattc tcatcaagag ggttaaaact    540

aatcatcagc tgatggcagt tcactttttg aattacaaaa aactttcccc ctcaggccat    600

ttattttact cataagcaac ctaactatat tatagattct aaaatattat ctccaaagcc    660

cctagaagat gcatacattt agtccaaaag gtttaataac tccccaagct gatatttccc    720

tttctccttt gatatttcca taatttggag tgcccattgt ctgttttatt tcatattggg    780

acaagctgaa cagggactaa ggtgaaggca gagaggcatt cagggcaaat cgtttaagga    840

ggtactacaa atacaaggtc aacacttgca ggaaactaag aaagagtgtc tccttaaaat    900

ttgtgtccta ggtgtcttat ctagttctgg cctttttaat gtgaattctt tttttttttt    960

tttttgagat gaagtctggc tctgtcaccc aggctagagt gcactggtgc gatctcgcct   1020

gactgcaacc tccacctcct gggttcaagg gattctcctg cctcagcctc ccaagtagct   1080

gggattacag gcatgcacca ccacacctgg ctaatttttg tatttttagt ggagacaggg   1140

tttcaccatg ttggccaggc tggtcttgaa ctcctgacct gaggtgatcc acccacctcg   1200

gcctcccaaa gtgctgtgat tacaggcatc aaccactgca cccagcttga attctttgtg   1260

tcctctaaaa actcaaaatt attttttagt attttaccag aaacatggga ggcatcaatt   1320

taaaaggaat gcacagaaga cacttcatca ctacttccaa ccaagcagta atgggctgga   1380

gatcctagat taagctactg gcagatctgg tgtctggcga gggctctgct cctggtttgc   1440

agatgggtgt cctctcatta tgccctcgca tggttgagag aaaaatcatc gttcttctgt   1500

ttcttcttag aagggcacta attttattca tgagctccat cctcatgacc taatcacagc   1560

ctaaaggcct cacctcctaa tactattata ttgggggttt agattgcaac gtatgtattt   1620

gggggggtcg gcacaaacat tcagctcata acatcttgtg aatcactttt aattgcaatg   1680

ttggaacatt gctttaaaat gatgcaggtc ttatttccat atatgcatta ggcagttctt   1740

gcattgctat aaagaaatac aggaaactgg gtaatttata aataaaagag gtttaattgg   1800

ctcacagttc tgtaggcttt acaggaagca tggtggtgct cagatctgct tggcatctag   1860

ggaggcctca ggaagcttcc attcatggca gaaggtgaag acagagtagg tatgtcgtgt   1920

agtaaaagca ggaatacgca agagacagag tggggggcgg tgccaaacac ttttaaatga   1980

ccacatctca tatgaattca gggcaagagc tcacttaatc accaaggggt tggcccaaac   2040

cattcatgag ggatctgccc ccattatcca aatccctctg ccagtctcca acattaggag   2100

ttacacttca acacgagatt tgagtgggga caaatatcca aactatatta agaagaaacg   2160

cagcagttcc caattttgtc tctcatcacc ctcccacaca ccaaatcata tatgtgagga   2220

gtacttttat atgcacaact tgccctattt agaactgttc tggaatgagt gcatttccca   2280

tagtactatc taaaattcca tcccctgcag ttcccttcaa gaaaccacat gacagtatca   2340

ataatgcatt gcattttagg aataaagtta aatattttct aatttatttt aaccattaat   2400

aaactgttct taactctttt tataacaata atttttagat cagttcacaa gtgattacaa   2460

cacacacggc agcaagatgg ataattgctg tcctaatgca tacattacac taaacattat   2520

tacatacaat gatattgcca aggatttaaa attttgatca gcagtttcag gaagctagga   2580

gcttttaact aaatggatga atcatggaga agagtcccgc catttctcgt tcaagattgg   2640

tgactcagtg tcagtgggac atgagacttc tatgatctga ccttagaatg accccttttt   2700

atggtggaac aaggttttaa gcaaggccat tcccctggag ccataaagga ttgactaggg   2760

aagattgcac tgagctttgc tatgaacagg gctgctgcat ttttgtgatt tttccccagt   2820

ctgtggtttt tcctgagcct gtatccagac agtggtcatt ccaagtccag ctttgctgtc   2880

tgttacagct tctgtttgac tatgtcttta tactcttgcc ttattaagtt ataaaactgt   2940

ttattgcttt attgtctcag ctcaaaggtg aataacaaaa ccccaagcat atgtcagcct   3000

tggaaattta gtattgacct tcctgggccc tcagtgcctg ctcatttcct atacctagca   3060

tttacgtttc caatgcttca tctacacctt cattcactac tacctatatg tcatttgcct   3120

tattatctat ggtacgtata ctgagttcta gtaaaatagt atttcaagtg caagtttaca   3180

cattccttat attaacttta attcaatact tgccatttct tttttgcttc agaaccagga   3240

gttgaaaata tttccatttg tcttttaaag aggttataaa attgtcacaa ggacatggga   3300

catgctggct atttttccct ttttactatt ttatagcatc caattaggtg gataataaaa   3360

ttcttatttt tccaatgagt agtccaagac ttcacgaata aaagtaccat gcttaatgtc   3420

acactactaa caagcggcag gaccagtgtt taaatgtaaa tatatcttat ttcaaaattt   3480

gtttgtttta ccaaattttg tagctccttc caagactccc aaccttcacc ttttctttct   3540

atccctaaga atacatatga ttttcacata cgaagttcgt ttataacctt ttgctaatta   3600

attagtgaaa aaagatgcaa tgaattttgc aaaatgtcat gcaaaaaatg aagcaggaac   3660

agacaattag gaaatattaa accatggtta gtagcattgc atatcagcat tggtttgatt   3720

gtaatttcat tgttctggac tctcgcttgt ttagttggtg tccctgaggc ctgcagtcct   3780

tccaggtgct gagagtggag cttcccaggc cttcatcctc tccaggacct caaccttcct   3840

cgttccatgt acagacatag agccctttcc acttcctttt tgtaagaaat agtattcttt   3900

cccacagatg tccagctcac accagcctgc tgcttgcctt tcactgaccc cttcgatgga   3960

tgctacggac ttggatccac tgccaaggaa acacgtcaca gagcagtgtg tggttggcat   4020

actaagctcc accaagaaag aagacatcac ccagagtcat gctgtattat ccagaatact   4080

tatgtgtctc cataccagag attgaccacc caaacttctt catttataaa aagcttctcc   4140

aagtacttga ttgcttgaaa ttggactata gtagcttcaa gaaacactta taaacattag   4200

ccaattac                                                            4208


<210>  7580
<211>  65
<212>  PRT
<213>  Homosapiens

<400>  7580

Met Ser Ser Ser His Gln Pro Ala Ala Cys Leu Ser Leu Thr Pro Ser 
1               5                   10                  15      


Met Asp Ala Thr Asp Leu Asp Pro Leu Pro Arg Lys His Val Thr Glu 
            20                  25                  30          


Gln Cys Val Val Gly Ile Leu Ser Ser Thr Lys Lys Glu Asp Ile Thr 
        35                  40                  45              


Gln Ser His Ala Val Leu Ser Arg Ile Leu Met Cys Leu His Thr Arg 
    50                  55                  60                  


Asp 
65  


<210>  7581
<211>  1610
<212>  DNA
<213>  Homosapiens

<400>  7581
acatctcgcg gcgaggagga gaggccggaa gggcgcccca gccccagggc tcctgccccg     60

cctgggcctc cggctttcgt ttccccgcaa cgcttcgctt tcgtttcccg ctggcgcctg    120

gctccctccg ggtttcgttt cccgccggcg cctggctccc gccaggtttc gtttccgagg    180

cggggccgag ggcggcgtcg ctgaggcgcc catggccttc gcccgccggc tcctgcgcgg    240

gccactgtcg gggccgctgc tcgggcggcg cggggtctgc gctggggcca tggctccgcc    300

gcgccgcttc gtcctggagc ttcccgactg caccctggct cacttcgccc taggcgccga    360

cgcccccggc gacgcagacg cccccgaccc ccgcctggcg gcgctgctgg ggcccccgga    420

gcgcagctac tcgctgtgcg tgcccgtgac cccggacgcc ggctgcgggg cccgggtccg    480

ggcggcgcgg ctgcaccagc gcctgctgca ccagctgcgc cgcggcccct tccagcggtg    540

ccagctgctc aggctgctct gctactgccc gggcggccag gccggcggcg cacagcaagg    600

cttcctgctg cgcgaccccc tggatgaccc tgacacccgg caagcgctgc tcgagctgct    660

gggcgcctgt caggaggcac cacgcccgca cttgggcgag ttcgaggccg acccgcgcgg    720

ccagctgtgg cagcgcctct gggaggtgca agacggcagg cggctgcagg tgggctgcgc    780

acaggtcgtg cccgtcccgg agcccccgct gcacccggtg gtgccagact tgcccagttc    840

cgtggtcttc ccggaccggg aagccgcccg ggccgttttg gaggagtgta cctcctttat    900

tcctgaagcc cgggcagtgc ttgacctggt cgaccagtgc ccaaaacaga tccagaaagg    960

aaagttccag gttgttgcca tcgaaggact ggatgccacg ggtaaaacca cggtgaccca   1020

gtcagtggca gattcactta aggctctgcc cccagcccat caccctgtgt accagtggcc   1080

agaggacctg ctcaaacctg accttatcct gctgctcact gtgagtcctg aggagaggtt   1140

gcagaggctg cagggccggg gcatggagaa gaccagggaa gaagcagaac ttgaggccaa   1200

cagtgtgttt cgtcaaaagg tagaaatgtc ctaccagcgg atggagaatc ctggctgcca   1260

tgtggttgat gccagcccct ccagagaaaa ggtcctgcag acggtcccag ctgggaggaa   1320

ccttatacca tccttctctc cacctgctcg gcagtgaagt ttgtgggact ggaatcttgg   1380

attcatcaca ctcgagtcaa ggcctggaat gacccctgac atcccagaag aacatctcag   1440

atatcagtgt gaaaagtctg gggatttcaa actgaaaatc caaaagataa gtaaatgagt   1500

gggaactctc tgttcagttc aatcccaccc ttccttacca gatactaaag tcatttctac   1560

ctttcctctt gagatttgct gttagatatt agaacttctc tttgtcacat              1610


<210>  7582
<211>  381
<212>  PRT
<213>  Homosapiens

<400>  7582

Met Ala Phe Ala Arg Arg Leu Leu Arg Gly Pro Leu Ser Gly Pro Leu 
1               5                   10                  15      


Leu Gly Arg Arg Gly Val Cys Ala Gly Ala Met Ala Pro Pro Arg Arg 
            20                  25                  30          


Phe Val Leu Glu Leu Pro Asp Cys Thr Leu Ala His Phe Ala Leu Gly 
        35                  40                  45              


Ala Asp Ala Pro Gly Asp Ala Asp Ala Pro Asp Pro Arg Leu Ala Ala 
    50                  55                  60                  


Leu Leu Gly Pro Pro Glu Arg Ser Tyr Ser Leu Cys Val Pro Val Thr 
65                  70                  75                  80  


Pro Asp Ala Gly Cys Gly Ala Arg Val Arg Ala Ala Arg Leu His Gln 
                85                  90                  95      


Arg Leu Leu His Gln Leu Arg Arg Gly Pro Phe Gln Arg Cys Gln Leu 
            100                 105                 110         


Leu Arg Leu Leu Cys Tyr Cys Pro Gly Gly Gln Ala Gly Gly Ala Gln 
        115                 120                 125             


Gln Gly Phe Leu Leu Arg Asp Pro Leu Asp Asp Pro Asp Thr Arg Gln 
    130                 135                 140                 


Ala Leu Leu Glu Leu Leu Gly Ala Cys Gln Glu Ala Pro Arg Pro His 
145                 150                 155                 160 


Leu Gly Glu Phe Glu Ala Asp Pro Arg Gly Gln Leu Trp Gln Arg Leu 
                165                 170                 175     


Trp Glu Val Gln Asp Gly Arg Arg Leu Gln Val Gly Cys Ala Gln Val 
            180                 185                 190         


Val Pro Val Pro Glu Pro Pro Leu His Pro Val Val Pro Asp Leu Pro 
        195                 200                 205             


Ser Ser Val Val Phe Pro Asp Arg Glu Ala Ala Arg Ala Val Leu Glu 
    210                 215                 220                 


Glu Cys Thr Ser Phe Ile Pro Glu Ala Arg Ala Val Leu Asp Leu Val 
225                 230                 235                 240 


Asp Gln Cys Pro Lys Gln Ile Gln Lys Gly Lys Phe Gln Val Val Ala 
                245                 250                 255     


Ile Glu Gly Leu Asp Ala Thr Gly Lys Thr Thr Val Thr Gln Ser Val 
            260                 265                 270         


Ala Asp Ser Leu Lys Ala Leu Pro Pro Ala His His Pro Val Tyr Gln 
        275                 280                 285             


Trp Pro Glu Asp Leu Leu Lys Pro Asp Leu Ile Leu Leu Leu Thr Val 
    290                 295                 300                 


Ser Pro Glu Glu Arg Leu Gln Arg Leu Gln Gly Arg Gly Met Glu Lys 
305                 310                 315                 320 


Thr Arg Glu Glu Ala Glu Leu Glu Ala Asn Ser Val Phe Arg Gln Lys 
                325                 330                 335     


Val Glu Met Ser Tyr Gln Arg Met Glu Asn Pro Gly Cys His Val Val 
            340                 345                 350         


Asp Ala Ser Pro Ser Arg Glu Lys Val Leu Gln Thr Val Pro Ala Gly 
        355                 360                 365             


Arg Asn Leu Ile Pro Ser Phe Ser Pro Pro Ala Arg Gln 
    370                 375                 380     


<210>  7583
<211>  2906
<212>  DNA
<213>  Homosapiens

<400>  7583
gtcgctgagg cgcccatggc cttcgcccgc cggctcctgc gcgggccact gtcggggccg     60

ctgctcgggc ggcgcggggt ctgcgctggg gccatggctc cgccgcgccg cttcgtcctg    120

gagcttcccg actgcaccct ggctcacttc gccctaggcg ccgacgcccc cggcgacgca    180

gacgcccccg acccccgcct ggcggcgctg ctggggcccc cggagcgcag ctactcgctg    240

tgcgtgcccg tgaccccgga cgccggctgc ggggcccggg tccgggcggc gcggctgcac    300

cagcgcctgc tgcaccagct gcgccgcggc cccttccagc ggtgccagct gctcaggctg    360

ctctgctact gcccgggcgg ccaggccggc ggcgcacagc aaggcttcct gctgcgcgac    420

cccctggatg accctgacac ccggcaagcg ctgctcgagc tgctgggcgc ctgtcaggag    480

gcaccacgcc cgcacttggg cgagttcgag gccgacccgc gcggccagct gtggcagcgc    540

ctctgggagg tgcaagacgg caggcggctg caggtgggct gcgcacaggt cgtgcccgtc    600

ccggagcccc cgctgcaccc ggtggtgcca gacttgccca gttccgtggt cttcccggac    660

cgggaagccg cccgggccgt tttggaggag tgtacctcct ttattcctga agcccgggca    720

gtgcttgacc tggtcgacca gtgcccaaaa cagatccaga aaggaaagtt ccaggttgtt    780

gccatcgaag gactggatgc cacgggtaaa accacggtga cccagtcagt ggcagattca    840

cttaaggctg tcctcttaaa gtcaccaccc tcttgcattg gccagtggag gaagatcttt    900

gatgatgaac caactatcat tagaagagct ttttactctt tgggcaatta tattgtggcc    960

tccgaaatag ctaaagaatc tgccaaatct cctgtgattg tagacaggta ctggcacagc   1020

acggccacct atgccatagc cactgaggtg agtgggggtc tccagcacct gcccccagcc   1080

catcaccctg tgtaccagtg gccagaggac ctgctcaaac ctgaccttat cctgctgctc   1140

actgtgagtc ctgaggagag gttgcagagg ctgcagggcc ggggcatgga gaagaccagg   1200

gaagaagcag aacttgaggc caacagtgtg tttcgtcaaa aggtagaaat gtcctaccag   1260

cggatggaga atcctggctg ccatgtggtt gatgccagcc cctccagaga aaaggtcctg   1320

cagacggtat taagcctaat ccagaatagt tttagtgaac cgtagttact ctggccaggt   1380

gccacgtcta actagattag atgttgtttg aaacatctac atccaccatt tgttatgcag   1440

tgttcccaaa tttctgttct acaagcatgt tgtgtggcag aaaactggag accaggcatc   1500

ttaattttac ttcagccatc gtaccctctt ctgactgatg gacccgtcat cacaaaggtc   1560

cctctcatca tgttccagtg agaggccagc gattgctttc ttcctggcat agtaaacatt   1620

ttcttggaac atatgtttca cttaatcact accaaatatc tggaagacct gtcttactca   1680

gacagcacca ggtgtacaga agcagcagac aagatcttcc agatcagcag ggagaccccg   1740

gagcctctgc ttctcctaca ctggcatgct gatgagatcg tgacatgccc acattggctt   1800

cttccacatc tggttgcact cgtcatgatg ggctcgctgc atctccctca gtcccaaatt   1860

ctagagccaa gtgttcctgc agaggctgtc tatgtgtcct ggctgcccaa ggacactcct   1920

gcagagccat ttttgggtaa ggaacactta caaagaaggc attgatcttg tgtctgaggc   1980

tcagagccct tttgataggc ttctgagtca tatataaaga cattcaagcc aagatgctcc   2040

aactgcaaat ataccaacct tctctgaatt atattttgct tatttatatt tcttttcttt   2100

ttttctaaag tatggctctg aatagaatgc acattttcca ttgaactgga tgcatttcat   2160

ttagccaatc cagtaattta tttatattaa tctatacata atatgtttcc tcagcatagg   2220

agctatgatt cattaattaa aagtggagtc aaaacgctaa atgcaatgtt tgttgtgtat   2280

tttcattaca caaacttaat ttgtcttgtt aaataagtac agtggatctt ggagtgggat   2340

ttcttggtaa attatcttgc acttgaatgt ctcatgatta catatgaaat cgctttgaca   2400

tatctttaga cagaaaaaag tagctgagtg agggggaaat tatagagctg tgtgacttta   2460

gggagtaggt tgaaccaggt gattacctaa aattccttcc agttcaaagg cagataaatc   2520

tgtaaattat tttatcctat ctaccatttc ttaagaagac attactccaa aataattaaa   2580

tttaaggctt tatcaggtct gcatatagaa tcttaaattc taataaagtt tcatgttaat   2640

gtcataggat ttttaaaaga gctataggta atttctatat aatatgtgta tattaaaatg   2700

taattgattt cagttgaaag tattttaaag ctgataaata gcattagggt tctttgcaat   2760

gtggtatcta gctgtattat tggttttatt tactttaaac attttgaaaa gcttatactg   2820

gcagcctaga aaaacaaaca attaatgtat ctttatgtcc ctggcacatg aataaacttt   2880

gctgtggttt actaatctat gctgtc                                        2906


<210>  7584
<211>  449
<212>  PRT
<213>  Homosapiens

<400>  7584

Met Ala Phe Ala Arg Arg Leu Leu Arg Gly Pro Leu Ser Gly Pro Leu 
1               5                   10                  15      


Leu Gly Arg Arg Gly Val Cys Ala Gly Ala Met Ala Pro Pro Arg Arg 
            20                  25                  30          


Phe Val Leu Glu Leu Pro Asp Cys Thr Leu Ala His Phe Ala Leu Gly 
        35                  40                  45              


Ala Asp Ala Pro Gly Asp Ala Asp Ala Pro Asp Pro Arg Leu Ala Ala 
    50                  55                  60                  


Leu Leu Gly Pro Pro Glu Arg Ser Tyr Ser Leu Cys Val Pro Val Thr 
65                  70                  75                  80  


Pro Asp Ala Gly Cys Gly Ala Arg Val Arg Ala Ala Arg Leu His Gln 
                85                  90                  95      


Arg Leu Leu His Gln Leu Arg Arg Gly Pro Phe Gln Arg Cys Gln Leu 
            100                 105                 110         


Leu Arg Leu Leu Cys Tyr Cys Pro Gly Gly Gln Ala Gly Gly Ala Gln 
        115                 120                 125             


Gln Gly Phe Leu Leu Arg Asp Pro Leu Asp Asp Pro Asp Thr Arg Gln 
    130                 135                 140                 


Ala Leu Leu Glu Leu Leu Gly Ala Cys Gln Glu Ala Pro Arg Pro His 
145                 150                 155                 160 


Leu Gly Glu Phe Glu Ala Asp Pro Arg Gly Gln Leu Trp Gln Arg Leu 
                165                 170                 175     


Trp Glu Val Gln Asp Gly Arg Arg Leu Gln Val Gly Cys Ala Gln Val 
            180                 185                 190         


Val Pro Val Pro Glu Pro Pro Leu His Pro Val Val Pro Asp Leu Pro 
        195                 200                 205             


Ser Ser Val Val Phe Pro Asp Arg Glu Ala Ala Arg Ala Val Leu Glu 
    210                 215                 220                 


Glu Cys Thr Ser Phe Ile Pro Glu Ala Arg Ala Val Leu Asp Leu Val 
225                 230                 235                 240 


Asp Gln Cys Pro Lys Gln Ile Gln Lys Gly Lys Phe Gln Val Val Ala 
                245                 250                 255     


Ile Glu Gly Leu Asp Ala Thr Gly Lys Thr Thr Val Thr Gln Ser Val 
            260                 265                 270         


Ala Asp Ser Leu Lys Ala Val Leu Leu Lys Ser Pro Pro Ser Cys Ile 
        275                 280                 285             


Gly Gln Trp Arg Lys Ile Phe Asp Asp Glu Pro Thr Ile Ile Arg Arg 
    290                 295                 300                 


Ala Phe Tyr Ser Leu Gly Asn Tyr Ile Val Ala Ser Glu Ile Ala Lys 
305                 310                 315                 320 


Glu Ser Ala Lys Ser Pro Val Ile Val Asp Arg Tyr Trp His Ser Thr 
                325                 330                 335     


Ala Thr Tyr Ala Ile Ala Thr Glu Val Ser Gly Gly Leu Gln His Leu 
            340                 345                 350         


Pro Pro Ala His His Pro Val Tyr Gln Trp Pro Glu Asp Leu Leu Lys 
        355                 360                 365             


Pro Asp Leu Ile Leu Leu Leu Thr Val Ser Pro Glu Glu Arg Leu Gln 
    370                 375                 380                 


Arg Leu Gln Gly Arg Gly Met Glu Lys Thr Arg Glu Glu Ala Glu Leu 
385                 390                 395                 400 


Glu Ala Asn Ser Val Phe Arg Gln Lys Val Glu Met Ser Tyr Gln Arg 
                405                 410                 415     


Met Glu Asn Pro Gly Cys His Val Val Asp Ala Ser Pro Ser Arg Glu 
            420                 425                 430         


Lys Val Leu Gln Thr Val Leu Ser Leu Ile Gln Asn Ser Phe Ser Glu 
        435                 440                 445             


Pro 
    


<210>  7585
<211>  2414
<212>  DNA
<213>  Homosapiens

<400>  7585
tgttaggcag caacagtgct gatgctggac tgtggcaggc agagggtgct atcctgacac     60

acttcacctt agtgcaggaa acttcaattt ggtggaagaa aggcgatttc gaggtgccaa    120

tctgggcgac acttcccagt tggagagtca gcaaaaggga gagggcaatt ccaagaagag    180

ggaaaagctt gtgcacagtg tacctccttt attcctgaag cccgggcagt gcttgacctg    240

gtcgaccagt gcccaaaaca gatccagaaa ggaaagttcc aggttgttgc catcgaagga    300

ctggatgcca cgggtaaaac cacggtgacc cagtcagtgg cagattcact taaggctgtc    360

ctcttaaagt caccaccctc ttgcattggc cagtggagga agatctttga tgatgaacca    420

actatcatta gaagagcttt ttactctttg ggcaattata ttgtggcctc cgaaatagct    480

aaagaatctg ccaaatctcc tgtgattgta gacaggtact ggcacagcac ggccacctat    540

gccatagcca ctgaggtgag tgggggtctc cagcacctgc ccccagccca tcaccctgtg    600

taccagtggc cagaggacct gctcaaacct gaccttatcc tgctgctcac tgtgagtcct    660

gaggagaggt tgcagaggct gcagggccgg ggcatggaga agaccaggga agaagcagaa    720

cttgaggcca acagtgtgtt tcgtcaaaag gtagaaatgt cctaccagcg gatggagaat    780

cctggctgcc atgtggttga tgccagcccc tccagagaaa aggtcctgca gacggtatta    840

agcctaatcc agaatagttt tagtgaaccg tagttactct ggccaggtgc cacgtctaac    900

tagattagat gttgtttgaa acatctacat ccaccatttg ttatgcagtg ttcccaaatt    960

tctgttctac aagcatgttg tgtggcagaa aactggagac caggcatctt aattttactt   1020

cagccatcgt accctcttct gactgatgga cccgtcatca caaaggtccc tctcatcatg   1080

ttccagtgag aggccagcga ttgctttctt cctggcatag taaacatttt cttggaacat   1140

atgtttcact taatcactac caaatatctg gaagacctgt cttactcaga cagcaccagg   1200

tgtacagaag cagcagacaa gatcttccag atcagcaggg agaccccgga gcctctgctt   1260

ctcctacact ggcatgctga tgagatcgtg acatgcccac attggcttct tccacatctg   1320

gttgcactcg tcatgatggg ctcgctgcat ctccctcagt cccaaattct agagccaagt   1380

gttcctgcag aggctgtcta tgtgtcctgg ctgcccaagg acactcctgc agagccattt   1440

ttgggtaagg aacacttaca aagaaggcat tgatcttgtg tctgaggctc agagcccttt   1500

tgataggctt ctgagtcata tataaagaca ttcaagccaa gatgctccaa ctgcaaatat   1560

accaaccttc tctgaattat attttgctta tttatatttc ttttcttttt ttctaaagta   1620

tggctctgaa tagaatgcac attttccatt gaactggatg catttcattt agccaatcca   1680

gtaatttatt tatattaatc tatacataat atgtttcctc agcataggag ctatgattca   1740

ttaattaaaa gtggagtcaa aacgctaaat gcaatgtttg ttgtgtattt tcattacaca   1800

aacttaattt gtcttgttaa ataagtacag tggatcttgg agtgggattt cttggtaaat   1860

tatcttgcac ttgaatgtct catgattaca tatgaaatcg ctttgacata tctttagaca   1920

gaaaaaagta gctgagtgag ggggaaatta tagagctgtg tgactttagg gagtaggttg   1980

aaccaggtga ttacctaaaa ttccttccag ttcaaaggca gataaatctg taaattattt   2040

tatcctatct accatttctt aagaagacat tactccaaaa taattaaatt taaggcttta   2100

tcaggtctgc atatagaatc ttaaattcta ataaagtttc atgttaatgt cataggattt   2160

ttaaaagagc tataggtaat ttctatataa tatgtgtata ttaaaatgta attgatttca   2220

gttgaaagta ttttaaagct gataaatagc attagggttc tttgcaatgt ggtatctagc   2280

tgtattattg gttttattta ctttaaacat tttgaaaagc ttatactggc agcctagaaa   2340

aacaaacaat taatgtatct ttatgtccct ggcacatgaa taaactttgc tgtggtttac   2400

taatctatgc tgtc                                                     2414


<210>  7586
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  7586

Met Glu Lys Thr Arg Glu Glu Ala Glu Leu Glu Ala Asn Ser Val Phe 
1               5                   10                  15      


Arg Gln Lys Val Glu Met Ser Tyr Gln Arg Met Glu Asn Pro Gly Cys 
            20                  25                  30          


His Val Val Asp Ala Ser Pro Ser Arg Glu Lys Val Leu Gln Thr Val 
        35                  40                  45              


Leu Ser Leu Ile Gln Asn Ser Phe Ser Glu Pro 
    50                  55                  


<210>  7587
<211>  643
<212>  DNA
<213>  Homosapiens

<400>  7587
agcgaagcgt tgcggggaaa cgaaagccgg aggcccaggc ggggcaggag ccctggggct     60

ggggcgccct tccggcctct cctcctcgcc gcgagatgtg cgcgataaac ggccggcgct    120

cgggagcaga cgcttggccc cggggcccca ggtgcgcggc tccgcgggcc tgcgcggtcc    180

ccaggcgccg gctcccgggg ctgacaccga atgaggcccc gcgccgtcgg ccccaagaat    240

atgacagtat cagaataaca ggagctaacc ctaactgaac acttaaagtt tgccaggcac    300

tattctgaat tcttcacaaa aattagcagt tttactctgc acaaaaatcg cctgagatac    360

gttgctttgc tgatgaagaa atggaaatcc agagaaataa agtcgcttac tcagtcaccc    420

agctacatga tttgtggctc tggaagttca gctactagga ctcttccaac ttcctacagg    480

tgtcacgaaa gcacaagacc acacacttac acacagttct gatgaaagag ggctaaaagg    540

aagatttcag taaaaaggtc aacaaggctt tctaaaaaaa ctgtaaaggt aaataaatga    600

tgtgtcgcag taattctcac caattaggaa gcatcttaga aaa                      643


<210>  7588
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  7588

Met Cys Ala Ile Asn Gly Arg Arg Ser Gly Ala Asp Ala Trp Pro Arg 
1               5                   10                  15      


Gly Pro Arg Cys Ala Ala Pro Arg Ala Cys Ala Val Pro Arg Arg Arg 
            20                  25                  30          


Leu Pro Gly Leu Thr Pro Asn Glu Ala Pro Arg Arg Arg Pro Gln Glu 
        35                  40                  45              


Tyr Asp Ser Ile Arg Ile Thr Gly Ala Asn Pro Asn 
    50                  55                  60  


<210>  7589
<211>  1494
<212>  DNA
<213>  Homosapiens

<400>  7589
tgtcctgctc cccaatgaca ggttgctcag agactgctga tttccatccc tatataaaga     60

gagtccctgg catacagaga ctgctctgct ccaggcatct gccacaatgt gggtgcttac    120

acctgctgct tttgctggga agctcttgag tgtgttcagg caacctctga gctctctgtg    180

gaggagcctg gtcccgctgt tctgctggct gagggcaacc ttctggctgc tagctaccaa    240

gaggagaaag cagcagctgg tcctgagagg gccagatgag accaaagagg aggaagagga    300

ccctcctctg cccaccaccc caaccagcgt caactatcac ttcactcgcc agtgcaacta    360

caaatgcggc ttctgtttcc acacagccaa aacatccttt gtgctgcccc ttgaggaagc    420

aaagagagga ttgcttttgc ttaaggaagc tggtatggag aagatcaact tttcaggtgg    480

agagccattt cttcaagacc ggggagaata cctgggcaag ttggtgaggt tctgcaaagt    540

agagttgcgg ctgcccagcg tgagcatcgt gagcaatgga agcctgatcc gggagaggtg    600

gttccagaat tatggtgagt atttggacat tctcgctatc tcctgtgaca gctttgacga    660

ggaagtcaat gtccttattg gccgtggcca aggaaagaag aaccatgtgg aaaaccttca    720

aaagctgagg aggtggtgta gggattatag agtcgctttc aagataaatt ctgtcattaa    780

tcgtttcaac gtggaagagg acatgacgga acagatcaaa gcactaaacc ctgtccgctg    840

gaaagtgttc cagtgcctct taattgaggg tgagaattgt ggagaagatg ctctaagaga    900

agcagaaaga tttgttattg gtgatgaaga atttgaaaga ttcttggagc gccacaaaga    960

agtgtcctgc ttggtgcctg aatctaacca gaagatgaaa gactcctacc ttattctgga   1020

tgaatatatg cgctttctga actgtagaaa gggacggaag gacccttcca agtccatcct   1080

ggatgttggt gtagaagaag ctataaaatt cagtggattt gatgaaaaga tgtttctgaa   1140

gcgaggagga aaatacatat ggagtaaggc tgatctgaag ctggattggt agagcggaaa   1200

gtggaacgag acttcaacac accagtggga aaactcctag agtaactgcc attgtctgca   1260

atactatccc gttggtattt cccagtggct gaaaacctga ttttctgctg cacgtggcat   1320

ctgattacct gtggtcactg aacacacgaa taacttggat agcaaatcct gagacaatgg   1380

aaaaccatta actttacttc attggcttat aaccttgttg ttattgaaac agcacttctg   1440

tttttgagtt tgttttagct aaaaagaagg aatacacaca ggaataatga cccc         1494


<210>  7590
<211>  361
<212>  PRT
<213>  Homosapiens

<400>  7590

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
            100                 105                 110         


Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
        115                 120                 125             


Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
    130                 135                 140                 


Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                165                 170                 175     


Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
            180                 185                 190         


Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
        195                 200                 205             


Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
    210                 215                 220                 


Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
225                 230                 235                 240 


Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                245                 250                 255     


Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
            260                 265                 270         


Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
        275                 280                 285             


Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
    290                 295                 300                 


Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
305                 310                 315                 320 


Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                325                 330                 335     


Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
            340                 345                 350         


Ser Lys Ala Asp Leu Lys Leu Asp Trp 
        355                 360     


<210>  7591
<211>  3348
<212>  DNA
<213>  Homosapiens

<400>  7591
tgtcctgctc cccaatgaca ggttgctcag agactgctga tttccatccc tatataaaga     60

gagtccctgg catacagaga ctgctctgct ccaggcatct gccacaatgt gggtgcttac    120

acctgctgct tttgctggga agctcttgag tgtgttcagg caacctctga gctctctgtg    180

gaggagcctg gtcccgctgt tctgctggct gagggcaacc ttctggctgc tagctaccaa    240

gaggagaaag cagcagctgg tcctgagagg gccagatgag accaaagagg aggaagagga    300

ccctcctctg cccaccaccc caaccagcgt caactatcac ttcactcgcc agtgcaacta    360

caaatgcggc ttctgtttcc acacagccaa aacatccttt gtgctgcccc ttgaggaagc    420

aaagagagga ttgcttttgc ttaaggaagc tggtatggag aagatcaact tttcaggtgg    480

agagccattt cttcaagacc ggggagaata cctgggcaag ttggtgaggt tctgcaaagt    540

agagttgcgg ctgcccagcg tgagcatcgt gagcaatgga agcctgatcc gggagaggtg    600

gttccagaat tatggtgagt atttggacat tctcgctatc tcctgtgaca gctttgacga    660

ggaagtcaat gtccttattg gccgtggcca aggaaagaag aaccatgtgg aaaaccttca    720

aaagctgagg aggtggtgta gggattatag agtcgctttc aagataaatt ctgtcattaa    780

tcgtttcaac gtggaagagg acatgacgga acagatcaaa gcactaaacc ctgtccgctg    840

gaaagtgttc cagtgcctct taattgaggg tgagaattgt ggagaagatg ctctaagaga    900

agcagaaaga tttgttattg gtgatgaaga atttgaaaga ttcttggagc gccacaaaga    960

agtgtcctgc ttggtgcctg aatctaacca gaagatgaaa gactcctacc ttattctgga   1020

tgaatatatg cgctttctga actgtagaaa gggacggaag gacccttcca agtccatcct   1080

ggatgttggt gtagaagaag ctataaaatt cagtggattt gatgaaaaga tgtttctgaa   1140

gcgaggagga aaatacatat ggagtaaggc tgatctgaag ctggattggt agagcggaaa   1200

gtggaacgag acttcaacac accagtggga aaactcctag agtaactgcc attgtctgca   1260

atactatccc gttggtattt cccagtggct gaaaacctga ttttctgctg cacgtggcat   1320

ctgattacct gtggtcactg aacacacgaa taacttggat agcaaatcct gagacaatgg   1380

aaaaccatta actttacttc attggcttat aaccttgttg ttattgaaac agcacttctg   1440

tttttgagtt tgttttagct aaaaagaagg aatacacaca ggaataatga ccccaaaaat   1500

gcttagataa ggcccctata cacaggacct gacatttagc tcaatgatgc gtttgtaaga   1560

aataagctct agtgatatct gtgggggcaa aatttaattt ggatttgatt ttttaaaaca   1620

atgtttactg cgatttctat atttccattt tgaaactatt tcttgttcca ggtttgttca   1680

tttgacagag tcagtatttt ttgccaaata tccagataac cagttttcac atctgagaca   1740

ttacaaagta tctgcctcaa ttatttctgc tggttataat gctttttttt ttttgccttt   1800

atgccattgc agtcttgtac tttttactgt gatgtacaga aatagtcaac agatgtttcc   1860

aagaacatat gatatgataa tcctaccaat tttcaagaag tctctagaaa gagataacac   1920

atggaaagac ggtgtggtgc agcccagccc acggtggctg ttccatgaat gctggctacc   1980

tatgtgtgtg gtacctgttg tgtccctttc tcttcaaaga tcctgagcaa aacaaagata   2040

cgctttccat ttgatgatgg agttgacatg gaggcagtgc ttgcattgct ttgttcgcct   2100

atcatctggc cacatgaggc tgtcaagcaa aagaatagga gtgtagttga gtagctggtt   2160

ggccctacat ctctgagaag tgacggcaca ctgggttggc ataagatatc ctaaaatcac   2220

gctggaacct tgggcaagga agaatgtgag caagagtaga gagagtgcct ggatttcatg   2280

tcagtgaagc caagtcacca tatcatattt ttgaatgaac tctgagtcag ttgaaatagg   2340

gtaccatcta ggtcagttta agaagagtca gctcagagaa agcaagcata agggaaaatg   2400

tcacgtaaac tagatcaggg aacaaaatcc tctccttgtg gaaatatccc atgcagtttg   2460

ttgatacaac ttagtatctt attgcctaaa aaaaaatttc ttatcattgt ttcaaaaaag   2520

caaaatcatg gaaaattttt gttgtccagg caaataaaag gtcattttaa tttaaggaaa   2580

aaaaatattc ctacttaaat tttaagtcta taattcaatt taaatatgtg tgtgtctcat   2640

ccaggatagg ataggttgtc ttctattttc cattttacct atttactttt tttgtaagaa   2700

aagagaaaaa tgaattctaa agatgttccc catgggtttt gattgtgtct aagctatgat   2760

gaccttcata taatcagcat aaacataaaa caaatttttt acttaacatg agtgcacttt   2820

actaatcctc atggcacagt ggctcacgcc tgtaatccca gcacttggga ggacaatgtg   2880

ggtggatcac gaggtcagga gttcgagaac agcctggcca acatggtgaa accccgtctc   2940

cactaaaaat acaaaaatta gccaggcatg gtggcgtaca cttgtaattc cagctactca   3000

agaggctgag gcaggaggat tgcttgaacc ctgaaggcag aggttacaga gccaagatag   3060

cgccactgca ctccagcctg gatgacagag caagactccg tctcaaaaaa aaaaaaaaaa   3120

aaaagcaaga gagttcaact aagaaaggtc acatatgtga aagcccaagg acactgtttg   3180

atatacagca ggtattcaat cagtgttatt tgaaaccaaa tctgaatttg aagtttgaat   3240

cttctgagtt ggaatgaatt tttttctagc tgagggaaac tgtatttttc tttccccaaa   3300

gaggaatgta atgtaaagtg aaataaaact ataagctatg ttaaatac                3348


<210>  7592
<211>  361
<212>  PRT
<213>  Homosapiens

<400>  7592

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
            100                 105                 110         


Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
        115                 120                 125             


Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
    130                 135                 140                 


Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                165                 170                 175     


Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
            180                 185                 190         


Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
        195                 200                 205             


Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
    210                 215                 220                 


Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
225                 230                 235                 240 


Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                245                 250                 255     


Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
            260                 265                 270         


Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
        275                 280                 285             


Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
    290                 295                 300                 


Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
305                 310                 315                 320 


Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                325                 330                 335     


Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
            340                 345                 350         


Ser Lys Ala Asp Leu Lys Leu Asp Trp 
        355                 360     


<210>  7593
<211>  888
<212>  DNA
<213>  Homosapiens

<400>  7593
gctctgctcc aggcatctgc cacaatgtgg gtgcttacac ctgctgcttt tgctgggaag     60

ctcttgagtg tgttcaggca acctctgagc tctctgtgga ggagcctggt cccgctgttc    120

tgctggctga gggcaacctt ctggctgcta gctaccaaga ggagaaagca gcagctggtc    180

ctgagagggc cagatgagac caaagaggag gaagaggacc ctcctctgcc caccacccca    240

accagcgtca actatcactt cactcgccag tgcaactaca aatgcggctt ctgtttccac    300

acagccaaaa catcctttgt gctgcccctt gaggaagcaa agagaggatt gcttttgctt    360

aaggaagctg gtatggagaa gatcaacttt tcaggtggag agccatttct tcaagaccgg    420

ggagaatacc tgggcaagtt ggtgaggttc tgcaaagtag agttgcggct gcccagcgtg    480

agcatcgtga gcaatggaag cctgatccgg gagaggtggt tccagaatta tggtgtgctc    540

catgggatgg cattcttctt attgctattg ctatttttat tgttggttct tatatttcct    600

tccctcctgg gccttcagcc aggcctgctg aggaactgga agggaggaaa aactaatctt    660

gcttactcta attgcttttc aagctgtgca cggcattatg gcagttttag ttccttaggg    720

ctctcagtaa acaagtttgg caagttagat aatagacctt ttactgagat gactatcttg    780

tacattgcaa tttagcaaat acaagatcta tggccttagt ttagacacta ggtaggaaaa    840

ttaacacatt tgacagcttt gtaataaaat atctctgttg ggactgga                 888


<210>  7594
<211>  256
<212>  PRT
<213>  Homosapiens

<400>  7594

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
            100                 105                 110         


Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
        115                 120                 125             


Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
    130                 135                 140                 


Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Val Leu His Gly Met Ala 
                165                 170                 175     


Phe Phe Leu Leu Leu Leu Leu Phe Leu Leu Leu Val Leu Ile Phe Pro 
            180                 185                 190         


Ser Leu Leu Gly Leu Gln Pro Gly Leu Leu Arg Asn Trp Lys Gly Gly 
        195                 200                 205             


Lys Thr Asn Leu Ala Tyr Ser Asn Cys Phe Ser Ser Cys Ala Arg His 
    210                 215                 220                 


Tyr Gly Ser Phe Ser Ser Leu Gly Leu Ser Val Asn Lys Phe Gly Lys 
225                 230                 235                 240 


Leu Asp Asn Arg Pro Phe Thr Glu Met Thr Ile Leu Tyr Ile Ala Ile 
                245                 250                 255     


<210>  7595
<211>  833
<212>  DNA
<213>  Homosapiens

<400>  7595
ctctgctcca ggcatctgcc acaatgtggg tgcttacacc tgctgctttt gctgggaagc     60

tcttgagtgt gttcaggcaa cctctgagct ctctgtggag gagcctggtc ccgctgttct    120

gctggctgag ggcaaccttc tggctgctag ctaccaagag gagaaagcag cagctggtcc    180

tgagagggcc agatgagacc aaagaggagg aagaggaccc tcctctgccc accaccccaa    240

ccagcgtcaa ctatcacttc actcgccagt gcaactacaa atgcggcttc tgtttccaca    300

cagccaaaac atcaggtatg gagaagatca acttttcagg tggagagcca tttcttcaag    360

accggggaga atacctgggc aagttggtga ggttctgcaa agtagagttg cggctgccca    420

gcgtgagcat cgtgagcaat ggaagcctga tccgggagag gtggttccag aattatggtg    480

tgctccatgg gatggcattc ttcttattgc tattgctatt tttattgttg gttcttatat    540

ttccttccct cctgggcctt cagccaggcc tgctgaggaa ctggaaggga ggaaaaacta    600

atcttgctta ctctaattgc ttttcaagct gtgcacggca ttatggcagt tttagttcct    660

tagggctctc agtaaacaag tttggcaagt tagataatag accttttact gagatgacta    720

tcttgtacat tgcaatttag caaatacaag atctatggcc ttagtttaga cactaggtag    780

gaaaattaac acatttgaca gctttgtaat aaaatatctc tgttgggact gga           833


<210>  7596
<211>  238
<212>  PRT
<213>  Homosapiens

<400>  7596

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe Leu Gln 
            100                 105                 110         


Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys Val Glu 
        115                 120                 125             


Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu Ile Arg 
    130                 135                 140                 


Glu Arg Trp Phe Gln Asn Tyr Gly Val Leu His Gly Met Ala Phe Phe 
145                 150                 155                 160 


Leu Leu Leu Leu Leu Phe Leu Leu Leu Val Leu Ile Phe Pro Ser Leu 
                165                 170                 175     


Leu Gly Leu Gln Pro Gly Leu Leu Arg Asn Trp Lys Gly Gly Lys Thr 
            180                 185                 190         


Asn Leu Ala Tyr Ser Asn Cys Phe Ser Ser Cys Ala Arg His Tyr Gly 
        195                 200                 205             


Ser Phe Ser Ser Leu Gly Leu Ser Val Asn Lys Phe Gly Lys Leu Asp 
    210                 215                 220                 


Asn Arg Pro Phe Thr Glu Met Thr Ile Leu Tyr Ile Ala Ile 
225                 230                 235             


<210>  7597
<211>  1530
<212>  DNA
<213>  Homosapiens

<400>  7597
gagaatacct gggcaagttg gtgaggttct gcaaagtaga gttgcggctg cccagcgtga     60

gcatcgtgac aaaacaaaga tacgctttcc atttgatgat ggagttgaca tggaggcagt    120

gcttgcattg ctttgttcgc ctatcatctg gccacatgag gctgtcaagc aaaagaatag    180

gagtgtagtt gagtagctgg ttggccctac atctctgaga agtgacggca cactgggttg    240

gcataagata tcctaaaatc acgctggaac cttgggcaag gaagaatgtg agcaagagta    300

gagagagtgc ctggatttca tgtcagtgaa gccaagtcac catatcatat ttttgaatga    360

actctgagtc agttgaaata gggtaccatc taggtcagtt taagaagagt cagctcagag    420

aaagcaagca taagggaaaa tgtcacgtaa actagatcag ggaacaaaat cctctccttg    480

tggaaatatc ccatgcagtt tgttgataca acttagtatc ttattgccta aaaaaaaatt    540

tcttatcatt gtttcaaaaa agcaaaatca tggaaaattt ttgttgtcca ggcaaataaa    600

aggtcatttt aatttagctg caatttcagt gttcctcact aggtggcatt taaatgtcgc    660

ctgatgtcat taagcaccat ccaaaaagtc tgcttcataa tctattttca agacttggtg    720

attctgaaag ttttggtttt tgtgactttg tttctcagga aaaaaaatat tcctacttaa    780

attttaagtc tataattcaa tttaaatatg tgtgtgtctc atccaggata ggataggttg    840

tcttctattt tccattttac ctatttactt tttttgtaag aaaagagaaa aatgaattct    900

aaagatgttc cccatgggtt ttgattgtgt ctaagctatg atgaccttca tataatcagc    960

ataaacataa aacaaatttt ttacttaaca tgagtgcact ttactaatcc tcatggcaca   1020

gtggctcacg cctgtaatcc cagcacttgg gaggacaatg tgggtggatc acgaggtcag   1080

gagttcgaga acagcctggc caacatggtg aaaccccgtc tccactaaaa atacaaaaat   1140

tagccaggca tggtggcgta cacttgtaat tccagctact caagaggctg aggcaggagg   1200

attgcttgaa ccctgaaggc agaggttaca gagccaagat agcgccactg cactccagcc   1260

tggatgacag agcaagactc cgtctcaaaa aaaaaaaaaa aaaaaagcaa gagagttcaa   1320

ctaagaaagg tcacatatgt gaaagcccaa ggacactgtt tgatatacag caggtattca   1380

atcagtgtta tttgaaacca aatctgaatt tgaagtttga atcttctgag ttggaatgaa   1440

tttttttcta gctgagggaa actgtatttt tctttcccca aagaggaatg taatgtaaag   1500

tgaaataaaa ctataagcta tgttaaatac                                    1530


<210>  7598
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  7598

Met Ser Arg Lys Leu Asp Gln Gly Thr Lys Ser Ser Pro Cys Gly Asn 
1               5                   10                  15      


Ile Pro Cys Ser Leu Leu Ile Gln Leu Ser Ile Leu Leu Pro Lys Lys 
            20                  25                  30          


Lys Phe Leu Ile Ile Val Ser Lys Lys Gln Asn His Gly Lys Phe Leu 
        35                  40                  45              


Leu Ser Arg Gln Ile Lys Gly His Phe Asn Leu Ala Ala Ile Ser Val 
    50                  55                  60                  


Phe Leu Thr Arg Trp His Leu Asn Val Ala 
65                  70                  


<210>  7599
<211>  1881
<212>  DNA
<213>  Homosapiens

<400>  7599
gagccttcct gagccaaccc tcgcaaggaa agtctgtctg ttcaccccac tatccttgtc     60

ttgaaggatg aagaaaagag ggccccccgg gaggtcccaa aaggtggaat ggacatctgg    120

gatccaagca cagcaatttc tttatttttc ttaaggtatc cagcttgttg gaatctaaga    180

tctgcgaagc ctctcactag aggatgaaaa tcgttctgca taaaggcctg ggctttatga    240

aaaatatatt cacacctccc gtgtccgagc tgggatacca aagaagttcc tggttgagta    300

ctacttatga atgaaggatt caggggatgc acaggacaca gaggaatctg ggggatatta    360

tggttctggg aatgtggaat gtaacgtctc atcttcagcc catctgtgct actgatcatc    420

tcattccaga agccatgcct tctctcagga gcagacagca caagactttc ctgccagagg    480

cacagtcccc agtgggagta gcatccacat aagacaggat gcagagatgt cttcaagcag    540

cttcaaacaa aacttcaaga aagaaagtgc aagtgaaaaa ggaaattcat ccttccagtc    600

acttaacaca gcactgtcac ggacaccttg tgcctcctta aaattcgtat actgaagttc    660

taagccccag taccccagaa tgtgaccttc tttggaaata gggtcattgc agatatgatt    720

agttaagagg agatcatact ggagtgggct ttaatccaat atgactggtg tccttatgta    780

aaggggaaat ttggacacag acacacacaa ggagaacacc atgtgaactg aagtcaaaga    840

tttgggtgat gcttctacaa gccaagaaat gccaaagatg accagcaaag caccggcagc    900

tggtggagga gcctggacca gattcttcct cacagccctc aaaaggaacc aatcttgcca    960

aagctttgac ttagacttct agccccctgt gatggttaat gttaagtggc agcttgactg   1020

ggttaaggga tgcccagata gctggtaaga cagtatgtct gtgtgcatct ctcagagtgt   1080

ttctggacaa gatcagcatt tgaatcctta gagtaaagaa gatctgccct cacccacgtg   1140

catcacccta tctctggaga gcgcgaacaa acaggaggaa gggcacatat gctccttctg   1200

ttccagctgg cacatccatc ttctcctgcc ccctgacttc agagctcctg gttctcgggc   1260

ctcaggattc cagcacttac atgagagcgt gcttccccct ccctactcca cccctaggtt   1320

ctccgccctt tggcctctga ctgaattcca ccaccagctt ttcagggtct ccagcttgca   1380

gacggcagat cgtgggactt cttggcctcc ataattatgt aagccaattc ccataataaa   1440

tctcctatct atctatctat ctatccatct atcaatcatc tatctagtct atctatctat   1500

ctatctctat cctattgatt ctgtgtctct gaggaaccct aatacacctc cagaactgtg   1560

agatgataca tttctgtggt ttaagccact cagaaggtgg tactttgttt caccaggcct   1620

agcaaactaa tacaagtgca tggaaggtga ctactcatga ctgcaactta gagaacaagg   1680

gttataataa aaataaaagt gttatacaaa ggtggcaaga taaatgacaa taaatgaaaa   1740

tattaacatg tgaattaaaa agtaaagata tttttcctag cattctccca gaaagtagag   1800

acgcgtctct cttgtttgcc atcatatcca gcaatggcaa gataagttct aggcacttca   1860

taaaaatttg ttgaatgaaa g                                             1881


<210>  7600
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  7600

Met His Arg Thr Gln Arg Asn Leu Gly Asp Ile Met Val Leu Gly Met 
1               5                   10                  15      


Trp Asn Val Thr Ser His Leu Gln Pro Ile Cys Ala Thr Asp His Leu 
            20                  25                  30          


Ile Pro Glu Ala Met Pro Ser Leu Arg Ser Arg Gln His Lys Thr Phe 
        35                  40                  45              


Leu Pro Glu Ala Gln Ser Pro Val Gly Val Ala Ser Thr 
    50                  55                  60      


<210>  7601
<211>  2954
<212>  DNA
<213>  Homosapiens

<400>  7601
acgccattct cctgcctcag cctcccgagt agctgggact acaggcgccc gccactgcgc     60

ccggctaatt ttttgtattt ttagtagaga gggggtttca ccgtggtctc gatctcctga    120

cctcgtgatc cgcccgcctc agcctcccaa agtgctggga ttacaggcgt gagccaccgc    180

gcccggccag ttcaatggat tttaaaaatt attattctct agaaaaaaga ccacgaactt    240

tggagtggac atcctgagac ctgcctacga agaccattag gtggcctcca gaagacactc    300

ccctgattcc tacaccgagg gaacacacag cagcaagcta ggaaagaagg ggtgacccag    360

cccaacgctg taaaccaggg cgcgaaccgg cgttgagctg tgcagctgcg ccctgggctc    420

cagtcctgct ctgccgcaga ccccaccgga gccagcacct gcctccccga ccctcgctgg    480

ggcggctgtg agatgagccc agagccttcc tgagccaacc ctcgcaagga aagtctgtct    540

gttcacccca ctatccttgt cttgaaggat gaagaaaaga gggccccccg ggaggtccca    600

aaaggtggaa tggacatctg ggatccaagc acagcaattt ctttattttt cttaaggtat    660

ccagcttgtt ggaatctaag atctgcgaag gtattaatag aattcctgca tcttctgcca    720

ctccccatag aagcttgaag ttacacaaat gttaaattat acgtcagatg tgcatatatg    780

aacaaaacct acgagtgtgc atgaaataac accttcttaa atatatagat tcttttttct    840

gcaatattaa atggaaaccc cactagaaca tcgtttttcc ttaatagcat accctccaca    900

ctgtgtggtc taaattcaag ctctaccacc tactagccat taagcaagtt attaaggtct    960

tcgtgcttcc attttcttac gtggaaaatg aggtggcaat agtatgtatg agttcttcgg   1020

agggattaaa caagtcaaat aggccaagtg ccatggctta cacctgtaag cccagcactt   1080

tgggaggcca aggcaggagg actgcttgag cccaggaggt caaggctgaa gtgagctgtg   1140

tttgcatcac tgcactccag cctgggcagc agagtgagac tttgtctctc aataaataaa   1200

gaaatagtca aattaaatat aactggcaaa ctaaaacaac tccatagtcc ttagctacaa   1260

tttgtctcat ttctccaaag aattaaatca gatgattctt aactaactca aagctctgca   1320

taatttgtct tctgctacac atacatcttt atagtaaaat aaaataaagc tgtcccctct   1380

gtattgagaa gttattctgg taaatatttg acctcttcaa atatatgaac gagcacttgc   1440

cttctaatgc ctcagtttca gattcttttt agaaatgtca ttattcaaga aaaatgcaca   1500

atgggaagaa tcttaacaac agcactttgt tacttcagcc tctcactaga ggatgaaaat   1560

cgttctgcat aaaggcctgg gctttatgaa aaatatattc acacctcccg tgtccgagct   1620

gggataccaa agaagttcct ggttgagtac tacttatgaa tgaaggattc aggggatgca   1680

caggtgggtg actgcaaatg cacagacgtt gtgctgtgtt ccccacaata aaggggtctg   1740

tattaagatg caggcattct catggaacac agacgtataa cactcaagct gggggactgc   1800

aaaggagcat ctggggctgc aggaagagag ttaaggtgca aaaatgccct gacccaactg   1860

agacttgtaa ttgctcatgt ggtaatacat gtgacttcat tcccctgctc tgtctttgtg   1920

aatgcaacca ttgttgggga gatagtgaga ggggacactg gcattgaaag ttttgtttgc   1980

agcaggcctc aaaaggcact cagatgcaga tttccctgca aagacttccc ggcctatcat   2040

ggagttcccc atccctagat ctctgatctc tgagctggtg taatacttag tctttgtctg   2100

tgttgatcat ggcatctgcc acacttaatg tttgtggcat tcactttctg atgcttagat   2160

cttacgattc tagagaacag catttttcta catattccct cttagggcct tgaacataat   2220

aagtgctcaa taaatactga gtgaaatcct ctactctgag ctttgcctct gagcagctgt   2280

cctagttctc tccaacaaga agtttgttgg gtctctcaag ttcacttcca cctgtcactg   2340

tcagttttca gtccagcccc ttactcaggt ctggctggcc catctccccc agagggctgt   2400

cccatagagc ccattgtaaa ggacactcat tgttgccaag agtttgtgcc aatgcagtat   2460

gactcaccct tcactcattg aacaagctct tcctgattac ctagatgggc aaaatttccc   2520

tgctcatgcg aagcaggctg gcgactcagt gctgcagcaa atggcccaga agctgggaaa   2580

gcagatagcc gttctgacac ttctcttcta gacagaaaat caagggaagc tcaagaccca   2640

cacttgaatt ttttttaaaa aattagacaa ggggctgggt gtggtggctc atgcctgtaa   2700

tcccagcact ttgggaggcc gaggcaggca gatcacctga ggttgggagt tcaagaccag   2760

cctgaccaac atggagaaac ccctgtctct gttaaaaata caaaattagc caggcgtggt   2820

ggcacatgcc tataatccca gctactcggg aggctaaggc aggagaatcg cttgaacccc   2880

agaggcagag gttgcggtga gccgagatcg caccactgca ctgcagcctg gcaacaagag   2940

cgaaactcag tctc                                                     2954


<210>  7602
<211>  98
<212>  PRT
<213>  Homosapiens

<400>  7602

Met Glu His Arg Arg Ile Thr Leu Lys Leu Gly Asp Cys Lys Gly Ala 
1               5                   10                  15      


Ser Gly Ala Ala Gly Arg Glu Leu Arg Cys Lys Asn Ala Leu Thr Gln 
            20                  25                  30          


Leu Arg Leu Val Ile Ala His Val Val Ile His Val Thr Ser Phe Pro 
        35                  40                  45              


Cys Ser Val Phe Val Asn Ala Thr Ile Val Gly Glu Ile Val Arg Gly 
    50                  55                  60                  


Asp Thr Gly Ile Glu Ser Phe Val Cys Ser Arg Pro Gln Lys Ala Leu 
65                  70                  75                  80  


Arg Cys Arg Phe Pro Cys Lys Asp Phe Pro Ala Tyr His Gly Val Pro 
                85                  90                  95      


His Pro 
        


<210>  7603
<211>  952
<212>  DNA
<213>  Homosapiens

<400>  7603
gagcctcccg cgtgcccggc ctctgtgcgc gctcgcgccc cgcccgcgca gccgcttctc     60

cccgcgcggg ctctcggcag gcgggaggcg gcagggctgg cattgcagtg cgggccgtgc    120

gggctgcgcg ggcgcgggga ggcgcgggcg gcaaactgcg ggcacccggc accccgcagc    180

cagtaccggg cggaggcgtc agagccgcgc accgcggacg agcaggccca ggcatccagt    240

accctgctga ctctgacatg cccccagcct cccccagctc tgcagggagc cctggtgcca    300

gagaccttct cccatttctc cctatgggtg cctgacctga gggcagagac atctgagtgt    360

gtataagcac agcaggacac caggacctgg cctgaagaca tttcctctcc tcccctctgg    420

atttctcaga gactgttctg cgatgaccac aacaaggtac cggcccacct gggacctggc    480

cctcgacccg ctggtgtctt gcaagctctg tcttggggag tacccagtgg agcagatgac    540

aaccatagcc cagtgccaat gcatcttctg tactctgtgc ctgaaacagt atgttgagct    600

cttgatcaaa gaaggattag aaactgcaat tagctgccca gatgctgcct gccctaaaca    660

gggccaccta caggagaacg agattgagtg catggttgca gctgaaatta tgcaaagata    720

taaaaagcta caatttgaaa gagaggtgct gtttgatccc tgtcggactt ggtgcccggc    780

gtccacctgc caagctgtgt gtcagctcca ggacgtgggg ctgcagaccc cccagccagt    840

gcagtgcaaa gcctgccgta tggaattctg ctccacctgc aaagccagct ggcaccctgg    900

ccagggctgc ccggagacca tgccgatcac cttcctcccc ggggagacca gg            952


<210>  7604
<211>  169
<212>  PRT
<213>  Homosapiens

<400>  7604

Met Thr Thr Thr Arg Tyr Arg Pro Thr Trp Asp Leu Ala Leu Asp Pro 
1               5                   10                  15      


Leu Val Ser Cys Lys Leu Cys Leu Gly Glu Tyr Pro Val Glu Gln Met 
            20                  25                  30          


Thr Thr Ile Ala Gln Cys Gln Cys Ile Phe Cys Thr Leu Cys Leu Lys 
        35                  40                  45              


Gln Tyr Val Glu Leu Leu Ile Lys Glu Gly Leu Glu Thr Ala Ile Ser 
    50                  55                  60                  


Cys Pro Asp Ala Ala Cys Pro Lys Gln Gly His Leu Gln Glu Asn Glu 
65                  70                  75                  80  


Ile Glu Cys Met Val Ala Ala Glu Ile Met Gln Arg Tyr Lys Lys Leu 
                85                  90                  95      


Gln Phe Glu Arg Glu Val Leu Phe Asp Pro Cys Arg Thr Trp Cys Pro 
            100                 105                 110         


Ala Ser Thr Cys Gln Ala Val Cys Gln Leu Gln Asp Val Gly Leu Gln 
        115                 120                 125             


Thr Pro Gln Pro Val Gln Cys Lys Ala Cys Arg Met Glu Phe Cys Ser 
    130                 135                 140                 


Thr Cys Lys Ala Ser Trp His Pro Gly Gln Gly Cys Pro Glu Thr Met 
145                 150                 155                 160 


Pro Ile Thr Phe Leu Pro Gly Glu Thr 
                165                 


<210>  7605
<211>  1812
<212>  DNA
<213>  Homosapiens

<400>  7605
gagcctcccg cgtgcccggc ctctgtgcgc gctcgcgccc cgcccgcgca gccgcttctc     60

cccgcgcggg ctctcggcag gcgggaggcg gcagggctgg cattgcagtg cgggccgtgc    120

gggctgcgcg ggcgcgggga ggcgcgggcg gcaaactgcg ggcacccggc accccgcagc    180

cagtaccggg cggaggcgtc agagccgcgc accgcggacg agcaggccca ggcatccagt    240

accctgctga ctctgacatg cccccagcct cccccagctc tgcagggagc cctggtgcca    300

gagaccttct cccatttctc cctatgggtg cctgacctga gggcagagac atctgagtgt    360

gtataagcac agcaggacac caggacctgg cctgaagaca tttcctctcc tcccctctgg    420

atttctcaga gactgttctg cgatgaccac aacaaggtac cggcccacct gggacctggc    480

cctcgacccg ctggtgtctt gcaagctctg tcttggggag tacccagtgg agcagatgac    540

aaccatagcc cagtgccaat gcatcttctg tactctgtgc ctgaaacagt atgttgagct    600

cttgatcaaa gaaggattag aaactgcaat tagctgccca gatgctgcct gccctaaaca    660

gggccaccta caggagaacg agattgagtg catggttgca gctgaaatta tgcaaagata    720

taaaaagcta caatttgaaa gagaggtgct gtttgatccc tgtcggactt ggtgcccggc    780

gtccacctgc caagctgtgt gtcagctcca ggacgtgggg ctgcagaccc cccagccagt    840

gcagtgcaaa gcctgccgta tggaattctg ctccacctgc aaagccagct ggcaccctgg    900

ccagggctgc ccggagacca tgccgatcac cttcctcccc ggggagacca gtgctgcttt    960

caaaatggaa gaagatgacg cgcccatcaa gcgctgcccc aagtgcaaag tctacatcga   1020

gcgagacgaa ggctgcgcgc agatgatgtg caagaactgc aagcacgcct tctgctggta   1080

ctgcctggag tctctggacg atgatttcct tctgatacac tacgataagg gaccctgccg   1140

gaacaagctg ggccactccc gggcatctgt gatctggcat cggacacagg ttgtgggcat   1200

ttttgcagga tttgggctgc tgctcttggt ggcctcacct ttcctactcc tggccactcc   1260

ctttgtactt tgctgcaagt gcaagtgcag taaaggtgac gacgacccgt tacccaccta   1320

gaggaagcgc gatgctggaa cacatccctg cctccgggaa gtgtggctct cccccaaccc   1380

tccccaccgt ccccccttca ctaaacatct ttcttgcctt atgtgcccca ttgagcttca   1440

cagtgtcagg ctggacgccg tgatttcagg gacctatgtc acaatgttcg ctgaggcccc   1500

aggtgtggtg gggaggggag gcaggtgtgg gtagcgcaca tccccacaga tcaatctctg   1560

cagatgacag ggaggtgctg tgagaagtgc accaggcagc tttctctctg tggtagacta   1620

ggcatgtctg gggatggcct aagagacttt ctgctccttg gcttctagat ggcaccatgt   1680

tgtcagagaa gtcttttaag gactgccact ctcttcagac agaatctgat tattccagct   1740

tgagagaagc actctgttta tgacaactgt ttttattact aatggcattt agtaaaatcc   1800

tttttagaag gt                                                       1812


<210>  7606
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  7606

Met Thr Thr Thr Arg Tyr Arg Pro Thr Trp Asp Leu Ala Leu Asp Pro 
1               5                   10                  15      


Leu Val Ser Cys Lys Leu Cys Leu Gly Glu Tyr Pro Val Glu Gln Met 
            20                  25                  30          


Thr Thr Ile Ala Gln Cys Gln Cys Ile Phe Cys Thr Leu Cys Leu Lys 
        35                  40                  45              


Gln Tyr Val Glu Leu Leu Ile Lys Glu Gly Leu Glu Thr Ala Ile Ser 
    50                  55                  60                  


Cys Pro Asp Ala Ala Cys Pro Lys Gln Gly His Leu Gln Glu Asn Glu 
65                  70                  75                  80  


Ile Glu Cys Met Val Ala Ala Glu Ile Met Gln Arg Tyr Lys Lys Leu 
                85                  90                  95      


Gln Phe Glu Arg Glu Val Leu Phe Asp Pro Cys Arg Thr Trp Cys Pro 
            100                 105                 110         


Ala Ser Thr Cys Gln Ala Val Cys Gln Leu Gln Asp Val Gly Leu Gln 
        115                 120                 125             


Thr Pro Gln Pro Val Gln Cys Lys Ala Cys Arg Met Glu Phe Cys Ser 
    130                 135                 140                 


Thr Cys Lys Ala Ser Trp His Pro Gly Gln Gly Cys Pro Glu Thr Met 
145                 150                 155                 160 


Pro Ile Thr Phe Leu Pro Gly Glu Thr Ser Ala Ala Phe Lys Met Glu 
                165                 170                 175     


Glu Asp Asp Ala Pro Ile Lys Arg Cys Pro Lys Cys Lys Val Tyr Ile 
            180                 185                 190         


Glu Arg Asp Glu Gly Cys Ala Gln Met Met Cys Lys Asn Cys Lys His 
        195                 200                 205             


Ala Phe Cys Trp Tyr Cys Leu Glu Ser Leu Asp Asp Asp Phe Leu Leu 
    210                 215                 220                 


Ile His Tyr Asp Lys Gly Pro Cys Arg Asn Lys Leu Gly His Ser Arg 
225                 230                 235                 240 


Ala Ser Val Ile Trp His Arg Thr Gln Val Val Gly Ile Phe Ala Gly 
                245                 250                 255     


Phe Gly Leu Leu Leu Leu Val Ala Ser Pro Phe Leu Leu Leu Ala Thr 
            260                 265                 270         


Pro Phe Val Leu Cys Cys Lys Cys Lys Cys Ser Lys Gly Asp Asp Asp 
        275                 280                 285             


Pro Leu Pro Thr 
    290         


<210>  7607
<211>  5654
<212>  DNA
<213>  Homosapiens

<400>  7607
gagcctcccg cgtgcccggc ctctgtgcgc gctcgcgccc cgcccgcgca gccgcttctc     60

cccgcgcggg ctctcggcag gcgggaggcg gcagggctgg cattgcagtg cgggccgtgc    120

gggctgcgcg ggcgcgggga ggcgcgggcg gcaaactgcg ggcacccggc accccgcagc    180

cagtaccggg cggaggcgtc agagccgcgc accgcggacg agcaggccca ggcatccagt    240

accctgctga ctctgacatg cccccagcct cccccagctc tgcagggagc cctggtgcca    300

gagaccttct cccatttctc cctatgggtg cctgacctga gggcagagac atctgagtgt    360

gtataagcac agcaggacac caggacctgg cctgaagaca tttcctctcc tcccctctgg    420

atttctcaga gactgttctg cgatgaccac aacaaggtac cggcccacct gggacctggc    480

cctcgacccg ctggtgtctt gcaagctctg tcttggggag tacccagtgg agcagatgac    540

aaccatagcc cagtgccaat gcatcttctg tactctgtgc ctgaaacagt atgttgagct    600

cttgatcaaa gaaggattag aaactgcaat tagctgccca gatgctgcct gccctaaaca    660

gggccaccta caggagaacg agattgagtg catggttgca gctgaaatta tgcaaagata    720

taaaaagcta caatttgaaa gagaggtgct gtttgatccc tgtcggactt ggtgcccggc    780

gtccacctgc caagctgtgt gtcagctcca ggacgtgggg ctgcagaccc cccagccagt    840

gcagtgcaaa gcctgccgta tggaattctg ctccacctgc aaagccagct ggcaccctgg    900

ccagggctgc ccggagacca tgccgatcac cttcctcccc ggggagacca gtgctgcttt    960

caaaatggaa gaagatgacg cgcccatcaa gcgctgcccc aagtgcaaag tctacatcga   1020

gcgagacgaa ggctgcgcgc agatgatgtg caagaactgc aagcacgcct tctgctggta   1080

ctgcctggag tctctggacg atgatttcct tctgatacac tacgataagg gaccctgccg   1140

gaacaagctg ggccactccc gggcatctgt gatctggcat cggacacagg ttgtgggcat   1200

ttttgcagga tttgggctgc tgctcttggt ggcctcacct ttcctactcc tggccactcc   1260

ctttgtactt tgctgcaagt gcaagtgcag taaaggtgac gacgacccgt tacccaccta   1320

gaggaagcgc gatgctggaa cacatccctg cctccgggaa gtgtggctct cccccaaccc   1380

tccccaccgt ccccccttca ctaaacatct ttcttgcctt atgtgcccca ttgagcttca   1440

cagtgtcagg ctggacgccg tgatttcagg gacctatgtc acaatgttcg ctgaggcccc   1500

aggtgtggtg gggaggggag gcaggtgtgg gtagcgcaca tccccacaga tcaatctctg   1560

cagatgacag ggaggtgctg tgagaagtgc accaggcagc tttctctctg tggtagacta   1620

ggcatgtctg gggatggcct aagagacttt ctgctccttg gcttctagat ggcaccatgt   1680

tgtcagagaa gtcttttaag gactgccact ctcttcagac agaatctgat tattccagct   1740

tgagagaagc actctgttta tgacaactgt ttttattact aatggcattt agtaaaatcc   1800

tttttagaag gtattttttt tccaactgag tagtgaaaat caacaaggtg catataaacc   1860

atcctatgcc tttcttgaaa tgtgcatttt aagaagttat agttaaacga cttttcagga   1920

gatttagaaa gccttatgca ctctttgtgt ttttcttgaa acttgctgta gtaacttttt   1980

gaacgctgta agctgtgtac tgttataagt gtgcttccta tattgttgca tttccttgat   2040

aatattgacg tgtttaaagg aacatctcat ctccattaga tttgcctttt gttgttttct   2100

ctctttggtg attcagctca gctcatgggc ctcatccctt ctctcccagg tagcagaaaa   2160

cgctttttat tgtattcaat cccactgctt tgctcggcaa tggttctcct ccgaattgct   2220

gccgtctggc ctctggcctc agtcttcaga tagacagtaa gaagaaagca gcctcattga   2280

tccgcagatg taggggcctc ttggcagagg ctggaggact ctgggggcta gggaagagcc   2340

tgccagattt tcacattttt aaaatgttct agtcattttg agaaatcata tatcttacac   2400

agttccaagt cctgttgcta accgttttgc tcttgttggg gaaaagaacc tcccatttca   2460

cttcgtttta acgtggggat tttaccactt gatcttttac agggctgtct gtgaccattt   2520

ccatggcagc aggatgcagg gattaataag gacacataca cattattcca ccaattgact   2580

ttgaaaagtg gagaaagtgt attctttaaa gagaatttac ttctaaaagc cacaggtgct   2640

tttacaaagc aaactgcatt gaatttaaaa cttctaaaaa taacaggcaa atattgtagc   2700

tatattacag tgggatttta aaaatcttgt taaacattct ataaagaagt aaaacaaaat   2760

ccttttatct cagttatttg cccatcacaa gcacattttt aaaatgttgc tttgtgtgtg   2820

tttgacttct gcatttgagt atcagtctca ggtcctagtt tactttccct ggttggaaat   2880

ttatttctta tttcctaaca ttgaattcgt tagaaaaaac agcgtcacct cactcttcac   2940

ctgtcatgtt gattttcctt atgaacccga agccatttag aaaatccctg tgtgtcaaaa   3000

ttacattcaa aaagctctcc ttgtaattgc aagtttagta actcagtaag aacatgcctg   3060

cgactccctt tctggatgga acctgggctg tggctctctg tcgtttgtgg tgctgtgatg   3120

gtgtctactg ttagaatagc ttttctggag gtgggtggca actccacgcg ggagtcattg   3180

gctgggcttg agccctcagc ctgtgatatg tggatgcagc tgtccagcca ctgcccttta   3240

acatgcccag cacacatggg aggcctgtgg ccctgtgtcc agtggcccac aggacacgcc   3300

tccaccatat gctcatcctt cctgcctgaa attgctgctg cccatcgcat gagcccacac   3360

agtagcaccc ccgtccttag gatgagagtc agagcctttg gaaaggctgc atccccaggg   3420

ctagagctca gatgacctta tttctagagg gacaggctgt tctgttggaa gagtctctgg   3480

cccagtcatg cacatctgta gccccagcca tccttgtgcc ttcacctctg atgtgtttca   3540

caagcacgta gttcaaccca gatagggacc acagagattc tggggccagc caggggcagt   3600

caaattggca cctactggct ctgacttttt gtatgaagca tgcctcagtt tcctcatttt   3660

gatctagata taaaattaaa attgtccatt tcctatataa ataccagcaa gatcactctg   3720

agatacataa actcgcattt ccttctgttt tagtaaggag tgccagactt atctttgatg   3780

ggaatacagt atgaaccctg cttgatgtaa aatggaaata gcacacaggc agatggccct   3840

gggtttggac tttgatcttg ccatcattcc ccagtaaaac ctggggagtt ctgcgttgag   3900

tggacggact tattcctgtg aagcggcata atttgtctcc attgaaaaat ggcattcact   3960

cttacagatg gtgttcactg caagccccag aagcatatgg catgtgttca ctaagaggcc   4020

tttaatcctg gggagtaagg ggcgaaggcc cttagacaac catggctgct gtactgccgc   4080

ccagggtggg tggccagtga ggactggcct tagcccagtg gacctgtggc ttctctgagg   4140

cccttgagta actgaccaca tttggaggtt ttgctggaaa tgcctgacct ctcagtctgg   4200

ctctgctgtg tagtccatag cccagccaga tgagcttgca gcctcatagg aggtcagcac   4260

cttgcaaaga tgcagtcacc atagatgtcc acgtagcaga gactgactta ggatctgaga   4320

taaagcatcg gattgcagga ataactgtcc aaattagttc ttcctcctca actcatagga   4380

gtagctgtgg acagaggaac caacatctgc cacctctggc attttctttc tttttttttc   4440

tttttgagac ggagtttcgc ttttgtcccc caagctggag tacaatgaca ggatctcggc   4500

tcactgcaag ctctgcctcc cgggttcaag cgattctcct gcctcagcct cccaagtagc   4560

tgggattaca ggcacccacc acctcaccca gctaattttt gtattttcag tagagacggg   4620

gtttcaccat gttggccagg ctactctcaa actcctgacc tcaggtgatc tgcccacctc   4680

ggcttcccaa agtgctggaa ttacaggcct gagccacccc acccggccta ttttcttaaa   4740

ggggaacaaa tgatcttgac aacatattat tccataaaac cagtttaggg cacaggccag   4800

ttcctgatta gaacacagga cctgtgggag ggactatcag agatgcaaaa attacttcaa   4860

gatgagttta ttgttttcat ttgtattgca aaagttagaa gtcattttac aaattaaaaa   4920

aacatttttt tcttggtagt ctttaaaaat taggggattg aaaggatcca ggatgggctt   4980

tgtgtgtgtg tctcagattc tcatttatta gtgagcacac ctgtgtatat atataaatca   5040

caaggagatc atcaagggaa aacattttgc atgtgtaaag cttcatgaag ttctctttaa   5100

aaaataccaa agcttgttta tttctgataa ttaacctaag cccttatgaa aataaacaaa   5160

atgaagggat tatgacaggt attaccaaaa acaccaaaag gaacaaaggg gcctgcgtta   5220

aaacctaatt gctaatgctt cacaactagg agagcatgcc gtcttgatgt ttaaaaaacc   5280

cagggtctcc acccttcctt tgatttgtgc aattctgtct tccacagttc cggagccttc   5340

agtgaggggt agctacatgc cccatgcctg ccctttcttt ccttctttgc tcactttact   5400

atgggtgtat tttaatcttg tataaaaata tgcatgaatg agtcatgcac atgtatacgt   5460

tatgtatttg acaagtggtg gtgaaacaaa atcaaaacag atttgatttg tgtttttgaa   5520

atgtcagtac attttgtgcc actaacactg tgatgtataa aagagctgtt tgaatgcctt   5580

ttaatgttgt gttttgtact ctggaatcat atggaaaaag tttgatttgt aatttcaata   5640

catattttaa atgt                                                     5654


<210>  7608
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  7608

Met Thr Thr Thr Arg Tyr Arg Pro Thr Trp Asp Leu Ala Leu Asp Pro 
1               5                   10                  15      


Leu Val Ser Cys Lys Leu Cys Leu Gly Glu Tyr Pro Val Glu Gln Met 
            20                  25                  30          


Thr Thr Ile Ala Gln Cys Gln Cys Ile Phe Cys Thr Leu Cys Leu Lys 
        35                  40                  45              


Gln Tyr Val Glu Leu Leu Ile Lys Glu Gly Leu Glu Thr Ala Ile Ser 
    50                  55                  60                  


Cys Pro Asp Ala Ala Cys Pro Lys Gln Gly His Leu Gln Glu Asn Glu 
65                  70                  75                  80  


Ile Glu Cys Met Val Ala Ala Glu Ile Met Gln Arg Tyr Lys Lys Leu 
                85                  90                  95      


Gln Phe Glu Arg Glu Val Leu Phe Asp Pro Cys Arg Thr Trp Cys Pro 
            100                 105                 110         


Ala Ser Thr Cys Gln Ala Val Cys Gln Leu Gln Asp Val Gly Leu Gln 
        115                 120                 125             


Thr Pro Gln Pro Val Gln Cys Lys Ala Cys Arg Met Glu Phe Cys Ser 
    130                 135                 140                 


Thr Cys Lys Ala Ser Trp His Pro Gly Gln Gly Cys Pro Glu Thr Met 
145                 150                 155                 160 


Pro Ile Thr Phe Leu Pro Gly Glu Thr Ser Ala Ala Phe Lys Met Glu 
                165                 170                 175     


Glu Asp Asp Ala Pro Ile Lys Arg Cys Pro Lys Cys Lys Val Tyr Ile 
            180                 185                 190         


Glu Arg Asp Glu Gly Cys Ala Gln Met Met Cys Lys Asn Cys Lys His 
        195                 200                 205             


Ala Phe Cys Trp Tyr Cys Leu Glu Ser Leu Asp Asp Asp Phe Leu Leu 
    210                 215                 220                 


Ile His Tyr Asp Lys Gly Pro Cys Arg Asn Lys Leu Gly His Ser Arg 
225                 230                 235                 240 


Ala Ser Val Ile Trp His Arg Thr Gln Val Val Gly Ile Phe Ala Gly 
                245                 250                 255     


Phe Gly Leu Leu Leu Leu Val Ala Ser Pro Phe Leu Leu Leu Ala Thr 
            260                 265                 270         


Pro Phe Val Leu Cys Cys Lys Cys Lys Cys Ser Lys Gly Asp Asp Asp 
        275                 280                 285             


Pro Leu Pro Thr 
    290         


<210>  7609
<211>  5743
<212>  DNA
<213>  Homosapiens

<400>  7609
gagcctcccg cgtgcccggc ctctgtgcgc gctcgcgccc cgcccgcgca gccgcttctc     60

cccgcgcggg ctctcggcag gcgggaggcg gcagggctgg cattgcagtg cgggccgtgc    120

gggctgcgcg ggcgcgggga ggcgcgggcg gcaaactgcg ggcacccggc accccgcagc    180

cagtaccggg cggaggcgtc agagccgcgc accgcggacg agcaggccca ggcatccagt    240

accctgctga ctctgacatg cccccagcct cccccagctc tgcagggagc cctggtgcca    300

gagaccttct cccatttctc cctatgggtg cctgacctga gggcagagac atctgagtgt    360

gtataagcac agcaggacac caggacctgg cctgaagaca tttcctctcc tcccctctgg    420

atttctcaga gactgttctg cgatgaccac aacaaggtac cggcccacct gggacctggc    480

cctcgacccg ctggtgtctt gcaagctctg tcttggggag tacccagtgg agcagatgac    540

aaccatagcc cagtgccaat gcatcttctg tactctgtgc ctgaaacagt atgttgagct    600

cttgatcaaa gaaggattag aaactgcaat tagctgccca gatgctgcct gccctaaaca    660

gggccaccta caggagaacg agattgagtg catggttgca gctgaaatta tgcaaagata    720

taaaaagcta caatttgaaa gagaggtgct gtttgatccc tgtcggactt ggtgcccggc    780

gtccacctgc caagctgtgt gtcagctcca ggacgtgggg ctgcagaccc cccagccagt    840

gcagtgcaaa gcctgccgta tggaattctg ctccacctgc aaagccagct ggcaccctgg    900

ccagggctgc ccggagacca tgccgatcac cttcctcccc ggggagacca gtgctgcttt    960

caaaatggaa gaagatgacg cgcccatcaa gcgctgcccc aagtgcaaag tctacatcga   1020

gcgagacgaa ggctgcgcgc agatgatgtg caagaactgc aagcacgcct tctgctggta   1080

ctgcctggag tctctggacg atgatttcct tctgatacac tacgataagg gaccctgccg   1140

gaacaagctg ggccactccc gggcatctgt gatctggcat cggacacagg ttgtgggcat   1200

ttttgcagga tttgggctgc tgctcttggt ggcctcacct ttcctactcc tggccactcc   1260

ctttgtactt tgctgcaagt gcaagtgcag taaaggtgac gacgacccgt tacccaccta   1320

gaggaagcgc gatgctggaa cacatccctg cctccgggaa gtgtggctct cccccaaccc   1380

tccccaccgt ccccccttca ctaaacatct ttcttgcctt atgtgcccca ttgagcttca   1440

cagtgtcagg ctggacgccg tgatttcagg gacctatgtc acaatgttcg ctgaggcccc   1500

aggtgtggtg gggaggggag gcaggtgtgg gtagcgcaca tccccacaga tcaatctctg   1560

cagatgacag ggaggtgctg tgagaagtgc accaggcagc tttctctctg tggtagacta   1620

ggcatgtctg gggatggcct aagagacttt ctgctccttg gcttctagat ggcaccatgt   1680

tgtcagagaa gtcttttaag gactgccact ctcttcagac agaatctgat tattccagct   1740

tgagagaagc actctgttta tgacaactgt ttttattact aatggcattt agtaaaatcc   1800

tttttagaag gtattttttt tccaactgag tagtgaaaat caacaaggtg catataaacc   1860

atcctatgcc tttcttgaaa tgtgcatttt aagaagttat agttaaacga cttttcagga   1920

gatttagaaa gccttatgca ctctttgtgt ttttcttgaa acttgctgta gtaacttttt   1980

gaacgctgta agctgtgtac tgttataagt gtgcttccta tattgttgca tttccttgat   2040

aatattgacg tgtttaaagg aacatctcat ctccattaga tttgcctttt gttgttttct   2100

ctctttggtg attcagctca gctcatgggc ctcatccctt ctctcccagg tagcagaaaa   2160

cgctttttat tgtattcaat cccactgctt tgctcggcaa tggttctcct ccgaattgct   2220

gccgtctggc ctctggcctc agtcttcaga tagacagtaa gaagaaagca gcctcattga   2280

tccgcagatg taggggcctc ttggcagagg ctggaggact ctgggggcta gggaagagcc   2340

tgccagattt tcacattttt aaaatgttct agtcattttg agaaatcata tatcttacac   2400

agttccaagt cctgttgcta accgttttgc tcttgttggg gaaaagaacc tcccatttca   2460

cttcgtttta acgtggggat tttaccactt gatcttttac agggctgtct gtgaccattt   2520

ccatggcagc aggatgcagg gattaataag gacacataca cattattcca ccaattgact   2580

ttgaaaagtg gagaaagtgt attctttaaa gagaatttac ttctaaaagc cacaggtgct   2640

tttacaaagc aaactgcatt gaatttaaaa cttctaaaaa taacaggcaa atattgtagc   2700

tatattacag tgggatttta aaaatcttgt taaacattct ataaagaagt aaaacaaaat   2760

ccttttatct cagttatttg cccatcacaa gcacattttt aaaatgttgc tttgtgtgtg   2820

tttgacttct gcatttgagt atcagtctca ggtcctagtt tactttccct ggttggaaat   2880

ttatttctta tttcctaaca ttgaattcgt tagaaaaaac agcgtcacct cactcttcac   2940

ctgtcatgtt gattttcctt atgaacccga agccatttag aaaatccctg tgtgtcaaaa   3000

ttacattcaa aaagctctcc ttgtaattgc aagtttagta actcagtaag aacatgcctg   3060

cgactccctt tctggatgga acctgggctg tggctctctg tcgtttgtgg tgctgtgatg   3120

gtgtctactg ttagaatagc ttttctggag gtgggtggca actccacgcg ggagtcattg   3180

gctgggcttg agccctcagc ctgtgatatg tggatgcagc tgtccagcca ctgcccttta   3240

acatgcccag cacacatggg aggcctgtgg ccctgtgtcc agtggcccac aggacacgcc   3300

tccaccatat gctcatcctt cctgcctgaa attgctgctg cccatcgcat gagcccacac   3360

agtagcaccc ccgtccttag gatgagagtc agagcctttg gaaaggctgc atccccaggg   3420

ctagagctca gatgacctta tttctagagg gacaggctgt tctgttggaa gagtctctgg   3480

cccagtcatg cacatctgta gccccagcca tccttgtgcc ttcacctctg atgtgtttca   3540

caagcacgta gttcaaccca gatagggacc acagagattc tggggccagc caggggcagt   3600

caaattggca cctactggct ctgacttttt gtatgaagca tgcctcagtt tcctcatttt   3660

gatctagata taaaattaaa attgtccatt tcctatataa ataccagcaa gatcactctg   3720

agatacataa actcgcattt ccttctgttt tagtaaggag tgccagactt atctttgatg   3780

ggaatacagt atgaaccctg cttgatgtaa aatggaaata gcacacaggc agatggccct   3840

gggtttggac tttgatcttg ccatcattcc ccagtaaaac ctggggagtt ctgcgttgag   3900

tggacggact tattcctgtg aagcggcata atttgtctcc attgaaaaat ggcattcact   3960

cttacagatg gtgttcactg caagccccag aagcatatgg catgtgttca ctaagaggcc   4020

tttaatcctg gggagtaagg ggcgaaggcc cttagacaac catggctgct gtactgccgc   4080

ccagggtggg tggccagtga ggactggcct tagcccagtg gacctgtggc ttctctgagg   4140

cccttgagta actgaccaca tttggaggtt ttgctggaaa tgcctgacct ctcagtctgg   4200

ctctgctgtg tagtccatag cccagccaga tgagcttgca gcctcatagg aggtcagcac   4260

cttgcaaaga tgcagtcacc atagatgtcc acgtagcaga gactgactta ggatctgaga   4320

taaagcatcg gattgcagga ataactgtcc aaattagttc ttcctcctca actcatagga   4380

gtagctgtgg acagaggaac caacatctgc cacctctggc attttctttc tttttttttc   4440

tttttgagac ggagtttcgc ttttgtcccc caagctggag tacaatgaca ggatctcggc   4500

tcactgcaag ctctgcctcc cgggttcaag cgattctcct gcctcagcct cccaagtagc   4560

tgggattaca ggcacccacc acctcaccca gctaattttt gtattttcag tagagacggg   4620

gtttcaccat gttggccagg ctactctcaa actcctgacc tcaggtgatc tgcccacctc   4680

ggcttcccaa agtgctggaa ttacaggcct gagccacccc acccggccta ttttcttaaa   4740

ggggaacaaa tgatcttgac aacatattat tccataaaac cagtttaggg cacaggccag   4800

ttcctgatta gaacacagga cctgtgggag ggactatcag agatgcaaaa attacttcaa   4860

gatgagttta ttgttttcat ttgtattgca aaagttagaa gtcattttac aaattaaaaa   4920

aacatttttt tcttggtagt ctttaaaaat taggggattg aaaggatcca ggatgggctt   4980

tgtgtgtgtg tctcagattc tcatttatta gtgagcacac ctgtgtatat atataaatca   5040

caaggagatc atcaagggaa aacattttgc atgtgtaaag cttcatgaag ttctctttaa   5100

aaaataccaa agcttgttta tttctgataa ttaacctaag cccttatgaa aataaacaaa   5160

atgaagggat tatgacaggt attaccaaaa acaccaaaag gaacaaaggg gcctgcgtta   5220

aaacctaatt gctaatgctt cacaactagg agagcatgcc gtcttgatgt ttaaaaaacc   5280

cagggtctcc acccttcctt tgatttgtgc aattctgtct tccacagttc cggagccttc   5340

agtgaggggt agctacatgc cccatgcctg ccctttcttt ccttctttgc tcactttact   5400

atgggtgtat tttaatcttg tataaaaata tgcatgaatg agtcatgcac atgtatacgt   5460

tatgtatttg acaagtggtg gtgaaacaaa atcaaaacag atttgatttg tgtttttgaa   5520

atgtcagtac attttgtgcc actaacactg tgatgtataa aagagctgtt tgaatgcctt   5580

ttaatgttgt gttttgtact ctggaatcat atggaaaaag tttgatttgt aatttcaata   5640

catattttaa atgtattgtg tcttacgtag tttgtccccc cctttagcag ggattccttt   5700

ttaaagctat tttggctgga atacaggtga cttttgtaaa ccc                     5743


<210>  7610
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  7610

Met Thr Thr Thr Arg Tyr Arg Pro Thr Trp Asp Leu Ala Leu Asp Pro 
1               5                   10                  15      


Leu Val Ser Cys Lys Leu Cys Leu Gly Glu Tyr Pro Val Glu Gln Met 
            20                  25                  30          


Thr Thr Ile Ala Gln Cys Gln Cys Ile Phe Cys Thr Leu Cys Leu Lys 
        35                  40                  45              


Gln Tyr Val Glu Leu Leu Ile Lys Glu Gly Leu Glu Thr Ala Ile Ser 
    50                  55                  60                  


Cys Pro Asp Ala Ala Cys Pro Lys Gln Gly His Leu Gln Glu Asn Glu 
65                  70                  75                  80  


Ile Glu Cys Met Val Ala Ala Glu Ile Met Gln Arg Tyr Lys Lys Leu 
                85                  90                  95      


Gln Phe Glu Arg Glu Val Leu Phe Asp Pro Cys Arg Thr Trp Cys Pro 
            100                 105                 110         


Ala Ser Thr Cys Gln Ala Val Cys Gln Leu Gln Asp Val Gly Leu Gln 
        115                 120                 125             


Thr Pro Gln Pro Val Gln Cys Lys Ala Cys Arg Met Glu Phe Cys Ser 
    130                 135                 140                 


Thr Cys Lys Ala Ser Trp His Pro Gly Gln Gly Cys Pro Glu Thr Met 
145                 150                 155                 160 


Pro Ile Thr Phe Leu Pro Gly Glu Thr Ser Ala Ala Phe Lys Met Glu 
                165                 170                 175     


Glu Asp Asp Ala Pro Ile Lys Arg Cys Pro Lys Cys Lys Val Tyr Ile 
            180                 185                 190         


Glu Arg Asp Glu Gly Cys Ala Gln Met Met Cys Lys Asn Cys Lys His 
        195                 200                 205             


Ala Phe Cys Trp Tyr Cys Leu Glu Ser Leu Asp Asp Asp Phe Leu Leu 
    210                 215                 220                 


Ile His Tyr Asp Lys Gly Pro Cys Arg Asn Lys Leu Gly His Ser Arg 
225                 230                 235                 240 


Ala Ser Val Ile Trp His Arg Thr Gln Val Val Gly Ile Phe Ala Gly 
                245                 250                 255     


Phe Gly Leu Leu Leu Leu Val Ala Ser Pro Phe Leu Leu Leu Ala Thr 
            260                 265                 270         


Pro Phe Val Leu Cys Cys Lys Cys Lys Cys Ser Lys Gly Asp Asp Asp 
        275                 280                 285             


Pro Leu Pro Thr 
    290         


<210>  7611
<211>  667
<212>  DNA
<213>  Homosapiens

<400>  7611
ctggcattgc agtgcgggcc gtgcgggctg cgcgggcgcg gggaggcgcg ggcggcaaac     60

tgcgggcacc cggcaccccg cagccagtac cgggcggagg cgtcagagcc gcgcaccgcg    120

gacgagcagg cccaggcatc cagtaccctg ctgactctga catgccccca gcctccccca    180

gctctgcagg gagccctggt gccagagacc ttctcccatt tctccctatg ggtgcctgac    240

ctgagggcag agacatctga gtgtgtataa gcacagcagg acaccaggac ctggcctgaa    300

gacatttcct ctcctcccct ctggatttct cagagacagt ctcgctgtgt cgcctaggct    360

ggagtgcagt ggcatgatct cggctcactg caaactctgc ttcccgggtt cacatcattc    420

tcctgcctca gcctccccag cagctgggac tacaggcgca cactgccacg cccggctaat    480

ttttgtattt ttagtagaga cggggtttca ccatgttagc caggatggtc tcgatctcct    540

gaccttgtga tccacctgcc tcagcctccc aaagtgctgg gattacaggc gtaagccacc    600

gcgcctggcc aaatctttta taaaattata ccttcaggct atgtgggtat aaggtgtata    660

tggagca                                                              667


<210>  7612
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  7612

Met Ile Ser Ala His Cys Lys Leu Cys Phe Pro Gly Ser His His Ser 
1               5                   10                  15      


Pro Ala Ser Ala Ser Pro Ala Ala Gly Thr Thr Gly Ala His Cys His 
            20                  25                  30          


Ala Arg Leu Ile Phe Val Phe Leu Val Glu Thr Gly Phe His His Val 
        35                  40                  45              


Ser Gln Asp Gly Leu Asp Leu Leu Thr Leu 
    50                  55              


<210>  7613
<211>  5333
<212>  DNA
<213>  Homosapiens

<400>  7613
tggcattgca gtgcgggccg tgcgggctgc gcgggcgcgg ggaggcgcgg gcggcaaact     60

gcgggcaccc ggcaccccgc agccagtacc gggcggaggc gtcagagccg cgcaccgcgg    120

acgagcaggc ccaggcatcc agtaccctgc tgactctgac atgcccccag cctcccccag    180

ctctgcaggg agccctggtg ccagagacct tctcccattt ctccctatgg gtgcctgacc    240

tgagggcaga gacatctgag tgtgtataag cacagcagga caccaggacc tggcctgaag    300

acatttcctc tcctcccctc tggatttctc agagaggtgc tgtttgatcc ctgtcggact    360

tggtgcccgg cgtccacctg ccaagctgtg tgtcagctcc aggacgtggg gctgcagacc    420

ccccagccag tgcagtgcaa agcctgccgt atggaattct gctccacctg caaagccagc    480

tggcaccctg gccagggctg cccggagacc atgccgatca ccttcctccc cggggagacc    540

aggtaccctt tgtacacaag ctgccaccaa aggcatggct gtgggccagg agaagcaggc    600

atgctttctt cctaaaagtg ctgttacagt tgctgctttc aaaatggaag aagatgacgc    660

gcccatcaag cgctgcccca agtgcaaagt ctacatcgag cgagacgaag gctgcgcgca    720

gatgatgtgc aagaactgca agcacgcctt ctgctggtac tgcctggagt ctctggacga    780

tgatttcctt ctgatacact acgataaggg accctgccgg aacaagctgg gccactcccg    840

ggcatctgtg atctggcatc ggacacaggt tgtgggcatt tttgcaggat ttgggctgct    900

gctcttggtg gcctcacctt tcctactcct ggccactccc tttgtacttt gctgcaagtg    960

caagtgcagt aaaggtgacg acgacccgtt acccacctag aggaagcgcg atgctggaac   1020

acatccctgc ctccgggaag tgtggctctc ccccaaccct ccccaccgtc cccccttcac   1080

taaacatctt tcttgcctta tgtgccccat tgagcttcac agtgtcaggc tggacgccgt   1140

gatttcaggg acctatgtca caatgttcgc tgaggcccca ggtgtggtgg ggaggggagg   1200

caggtgtggg tagcgcacat ccccacagat caatctctgc agatgacagg gaggtgctgt   1260

gagaagtgca ccaggcagct ttctctctgt ggtagactag gcatgtctgg ggatggccta   1320

agagactttc tgctccttgg cttctagatg gcaccatgtt gtcagagaag tcttttaagg   1380

actgccactc tcttcagaca gaatctgatt attccagctt gagagaagca ctctgtttat   1440

gacaactgtt tttattacta atggcattta gtaaaatcct ttttagaagg tatttttttt   1500

ccaactgagt agtgaaaatc aacaaggtgc atataaacca tcctatgcct ttcttgaaat   1560

gtgcatttta agaagttata gttaaacgac ttttcaggag atttagaaag ccttatgcac   1620

tctttgtgtt tttcttgaaa cttgctgtag taactttttg aacgctgtaa gctgtgtact   1680

gttataagtg tgcttcctat attgttgcat ttccttgata atattgacgt gtttaaagga   1740

acatctcatc tccattagat ttgccttttg ttgttttctc tctttggtga ttcagctcag   1800

ctcatgggcc tcatcccttc tctcccaggt agcagaaaac gctttttatt gtattcaatc   1860

ccactgcttt gctcggcaat ggttctcctc cgaattgctg ccgtctggcc tctggcctca   1920

gtcttcagat agacagtaag aagaaagcag cctcattgat ccgcagatgt aggggcctct   1980

tggcagaggc tggaggactc tgggggctag ggaagagcct gccagatttt cacattttta   2040

aaatgttcta gtcattttga gaaatcatat atcttacaca gttccaagtc ctgttgctaa   2100

ccgttttgct cttgttgggg aaaagaacct cccatttcac ttcgttttaa cgtggggatt   2160

ttaccacttg atcttttaca gggctgtctg tgaccatttc catggcagca ggatgcaggg   2220

attaataagg acacatacac attattccac caattgactt tgaaaagtgg agaaagtgta   2280

ttctttaaag agaatttact tctaaaagcc acaggtgctt ttacaaagca aactgcattg   2340

aatttaaaac ttctaaaaat aacaggcaaa tattgtagct atattacagt gggattttaa   2400

aaatcttgtt aaacattcta taaagaagta aaacaaaatc cttttatctc agttatttgc   2460

ccatcacaag cacattttta aaatgttgct ttgtgtgtgt ttgacttctg catttgagta   2520

tcagtctcag gtcctagttt actttccctg gttggaaatt tatttcttat ttcctaacat   2580

tgaattcgtt agaaaaaaca gcgtcacctc actcttcacc tgtcatgttg attttcctta   2640

tgaacccgaa gccatttaga aaatccctgt gtgtcaaaat tacattcaaa aagctctcct   2700

tgtaattgca agtttagtaa ctcagtaaga acatgcctgc gactcccttt ctggatggaa   2760

cctgggctgt ggctctctgt cgtttgtggt gctgtgatgg tgtctactgt tagaatagct   2820

tttctggagg tgggtggcaa ctccacgcgg gagtcattgg ctgggcttga gccctcagcc   2880

tgtgatatgt ggatgcagct gtccagccac tgccctttaa catgcccagc acacatggga   2940

ggcctgtggc cctgtgtcca gtggcccaca ggacacgcct ccaccatatg ctcatccttc   3000

ctgcctgaaa ttgctgctgc ccatcgcatg agcccacaca gtagcacccc cgtccttagg   3060

atgagagtca gagcctttgg aaaggctgca tccccagggc tagagctcag atgaccttat   3120

ttctagaggg acaggctgtt ctgttggaag agtctctggc ccagtcatgc acatctgtag   3180

ccccagccat ccttgtgcct tcacctctga tgtgtttcac aagcacgtag ttcaacccag   3240

atagggacca cagagattct ggggccagcc aggggcagtc aaattggcac ctactggctc   3300

tgactttttg tatgaagcat gcctcagttt cctcattttg atctagatat aaaattaaaa   3360

ttgtccattt cctatataaa taccagcaag atcactctga gatacataaa ctcgcatttc   3420

cttctgtttt agtaaggagt gccagactta tctttgatgg gaatacagta tgaaccctgc   3480

ttgatgtaaa atggaaatag cacacaggca gatggccctg ggtttggact ttgatcttgc   3540

catcattccc cagtaaaacc tggggagttc tgcgttgagt ggacggactt attcctgtga   3600

agcggcataa tttgtctcca ttgaaaaatg gcattcactc ttacagatgg tgttcactgc   3660

aagccccaga agcatatggc atgtgttcac taagaggcct ttaatcctgg ggagtaaggg   3720

gcgaaggccc ttagacaacc atggctgctg tactgccgcc cagggtgggt ggccagtgag   3780

gactggcctt agcccagtgg acctgtggct tctctgaggc ccttgagtaa ctgaccacat   3840

ttggaggttt tgctggaaat gcctgacctc tcagtctggc tctgctgtgt agtccatagc   3900

ccagccagat gagcttgcag cctcatagga ggtcagcacc ttgcaaagat gcagtcacca   3960

tagatgtcca cgtagcagag actgacttag gatctgagat aaagcatcgg attgcaggaa   4020

taactgtcca aattagttct tcctcctcaa ctcataggag tagctgtgga cagaggaacc   4080

aacatctgcc acctctggca ttttctttct ttttttttct ttttgagacg gagtttcgct   4140

tttgtccccc aagctggagt acaatgacag gatctcggct cactgcaagc tctgcctccc   4200

gggttcaagc gattctcctg cctcagcctc ccaagtagct gggattacag gcacccacca   4260

cctcacccag ctaatttttg tattttcagt agagacgggg tttcaccatg ttggccaggc   4320

tactctcaaa ctcctgacct caggtgatct gcccacctcg gcttcccaaa gtgctggaat   4380

tacaggcctg agccacccca cccggcctat tttcttaaag gggaacaaat gatcttgaca   4440

acatattatt ccataaaacc agtttagggc acaggccagt tcctgattag aacacaggac   4500

ctgtgggagg gactatcaga gatgcaaaaa ttacttcaag atgagtttat tgttttcatt   4560

tgtattgcaa aagttagaag tcattttaca aattaaaaaa acattttttt cttggtagtc   4620

tttaaaaatt aggggattga aaggatccag gatgggcttt gtgtgtgtgt ctcagattct   4680

catttattag tgagcacacc tgtgtatata tataaatcac aaggagatca tcaagggaaa   4740

acattttgca tgtgtaaagc ttcatgaagt tctctttaaa aaataccaaa gcttgtttat   4800

ttctgataat taacctaagc ccttatgaaa ataaacaaaa tgaagggatt atgacaggta   4860

ttaccaaaaa caccaaaagg aacaaagggg cctgcgttaa aacctaattg ctaatgcttc   4920

acaactagga gagcatgccg tcttgatgtt taaaaaaccc agggtctcca cccttccttt   4980

gatttgtgca attctgtctt ccacagttcc ggagccttca gtgaggggta gctacatgcc   5040

ccatgcctgc cctttctttc cttctttgct cactttacta tgggtgtatt ttaatcttgt   5100

ataaaaatat gcatgaatga gtcatgcaca tgtatacgtt atgtatttga caagtggtgg   5160

tgaaacaaaa tcaaaacaga tttgatttgt gtttttgaaa tgtcagtaca ttttgtgcca   5220

ctaacactgt gatgtataaa agagctgttt gaatgccttt taatgttgtg ttttgtactc   5280

tggaatcata tggaaaaagt ttgatttgta atttcaatac atattttaaa tgt          5333


<210>  7614
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  7614

Met Ala Val Gly Gln Glu Lys Gln Ala Cys Phe Leu Pro Lys Ser Ala 
1               5                   10                  15      


Val Thr Val Ala Ala Phe Lys Met Glu Glu Asp Asp Ala Pro Ile Lys 
            20                  25                  30          


Arg Cys Pro Lys Cys Lys Val Tyr Ile Glu Arg Asp Glu Gly Cys Ala 
        35                  40                  45              


Gln Met Met Cys Lys Asn Cys Lys His Ala Phe Cys Trp Tyr Cys Leu 
    50                  55                  60                  


Glu Ser Leu Asp Asp Asp Phe Leu Leu Ile His Tyr Asp Lys Gly Pro 
65                  70                  75                  80  


Cys Arg Asn Lys Leu Gly His Ser Arg Ala Ser Val Ile Trp His Arg 
                85                  90                  95      


Thr Gln Val Val Gly Ile Phe Ala Gly Phe Gly Leu Leu Leu Leu Val 
            100                 105                 110         


Ala Ser Pro Phe Leu Leu Leu Ala Thr Pro Phe Val Leu Cys Cys Lys 
        115                 120                 125             


Cys Lys Cys Ser Lys Gly Asp Asp Asp Pro Leu Pro Thr 
    130                 135                 140     


<210>  7615
<211>  5422
<212>  DNA
<213>  Homosapiens

<400>  7615
tggcattgca gtgcgggccg tgcgggctgc gcgggcgcgg ggaggcgcgg gcggcaaact     60

gcgggcaccc ggcaccccgc agccagtacc gggcggaggc gtcagagccg cgcaccgcgg    120

acgagcaggc ccaggcatcc agtaccctgc tgactctgac atgcccccag cctcccccag    180

ctctgcaggg agccctggtg ccagagacct tctcccattt ctccctatgg gtgcctgacc    240

tgagggcaga gacatctgag tgtgtataag cacagcagga caccaggacc tggcctgaag    300

acatttcctc tcctcccctc tggatttctc agagaggtgc tgtttgatcc ctgtcggact    360

tggtgcccgg cgtccacctg ccaagctgtg tgtcagctcc aggacgtggg gctgcagacc    420

ccccagccag tgcagtgcaa agcctgccgt atggaattct gctccacctg caaagccagc    480

tggcaccctg gccagggctg cccggagacc atgccgatca ccttcctccc cggggagacc    540

aggtaccctt tgtacacaag ctgccaccaa aggcatggct gtgggccagg agaagcaggc    600

atgctttctt cctaaaagtg ctgttacagt tgctgctttc aaaatggaag aagatgacgc    660

gcccatcaag cgctgcccca agtgcaaagt ctacatcgag cgagacgaag gctgcgcgca    720

gatgatgtgc aagaactgca agcacgcctt ctgctggtac tgcctggagt ctctggacga    780

tgatttcctt ctgatacact acgataaggg accctgccgg aacaagctgg gccactcccg    840

ggcatctgtg atctggcatc ggacacaggt tgtgggcatt tttgcaggat ttgggctgct    900

gctcttggtg gcctcacctt tcctactcct ggccactccc tttgtacttt gctgcaagtg    960

caagtgcagt aaaggtgacg acgacccgtt acccacctag aggaagcgcg atgctggaac   1020

acatccctgc ctccgggaag tgtggctctc ccccaaccct ccccaccgtc cccccttcac   1080

taaacatctt tcttgcctta tgtgccccat tgagcttcac agtgtcaggc tggacgccgt   1140

gatttcaggg acctatgtca caatgttcgc tgaggcccca ggtgtggtgg ggaggggagg   1200

caggtgtggg tagcgcacat ccccacagat caatctctgc agatgacagg gaggtgctgt   1260

gagaagtgca ccaggcagct ttctctctgt ggtagactag gcatgtctgg ggatggccta   1320

agagactttc tgctccttgg cttctagatg gcaccatgtt gtcagagaag tcttttaagg   1380

actgccactc tcttcagaca gaatctgatt attccagctt gagagaagca ctctgtttat   1440

gacaactgtt tttattacta atggcattta gtaaaatcct ttttagaagg tatttttttt   1500

ccaactgagt agtgaaaatc aacaaggtgc atataaacca tcctatgcct ttcttgaaat   1560

gtgcatttta agaagttata gttaaacgac ttttcaggag atttagaaag ccttatgcac   1620

tctttgtgtt tttcttgaaa cttgctgtag taactttttg aacgctgtaa gctgtgtact   1680

gttataagtg tgcttcctat attgttgcat ttccttgata atattgacgt gtttaaagga   1740

acatctcatc tccattagat ttgccttttg ttgttttctc tctttggtga ttcagctcag   1800

ctcatgggcc tcatcccttc tctcccaggt agcagaaaac gctttttatt gtattcaatc   1860

ccactgcttt gctcggcaat ggttctcctc cgaattgctg ccgtctggcc tctggcctca   1920

gtcttcagat agacagtaag aagaaagcag cctcattgat ccgcagatgt aggggcctct   1980

tggcagaggc tggaggactc tgggggctag ggaagagcct gccagatttt cacattttta   2040

aaatgttcta gtcattttga gaaatcatat atcttacaca gttccaagtc ctgttgctaa   2100

ccgttttgct cttgttgggg aaaagaacct cccatttcac ttcgttttaa cgtggggatt   2160

ttaccacttg atcttttaca gggctgtctg tgaccatttc catggcagca ggatgcaggg   2220

attaataagg acacatacac attattccac caattgactt tgaaaagtgg agaaagtgta   2280

ttctttaaag agaatttact tctaaaagcc acaggtgctt ttacaaagca aactgcattg   2340

aatttaaaac ttctaaaaat aacaggcaaa tattgtagct atattacagt gggattttaa   2400

aaatcttgtt aaacattcta taaagaagta aaacaaaatc cttttatctc agttatttgc   2460

ccatcacaag cacattttta aaatgttgct ttgtgtgtgt ttgacttctg catttgagta   2520

tcagtctcag gtcctagttt actttccctg gttggaaatt tatttcttat ttcctaacat   2580

tgaattcgtt agaaaaaaca gcgtcacctc actcttcacc tgtcatgttg attttcctta   2640

tgaacccgaa gccatttaga aaatccctgt gtgtcaaaat tacattcaaa aagctctcct   2700

tgtaattgca agtttagtaa ctcagtaaga acatgcctgc gactcccttt ctggatggaa   2760

cctgggctgt ggctctctgt cgtttgtggt gctgtgatgg tgtctactgt tagaatagct   2820

tttctggagg tgggtggcaa ctccacgcgg gagtcattgg ctgggcttga gccctcagcc   2880

tgtgatatgt ggatgcagct gtccagccac tgccctttaa catgcccagc acacatggga   2940

ggcctgtggc cctgtgtcca gtggcccaca ggacacgcct ccaccatatg ctcatccttc   3000

ctgcctgaaa ttgctgctgc ccatcgcatg agcccacaca gtagcacccc cgtccttagg   3060

atgagagtca gagcctttgg aaaggctgca tccccagggc tagagctcag atgaccttat   3120

ttctagaggg acaggctgtt ctgttggaag agtctctggc ccagtcatgc acatctgtag   3180

ccccagccat ccttgtgcct tcacctctga tgtgtttcac aagcacgtag ttcaacccag   3240

atagggacca cagagattct ggggccagcc aggggcagtc aaattggcac ctactggctc   3300

tgactttttg tatgaagcat gcctcagttt cctcattttg atctagatat aaaattaaaa   3360

ttgtccattt cctatataaa taccagcaag atcactctga gatacataaa ctcgcatttc   3420

cttctgtttt agtaaggagt gccagactta tctttgatgg gaatacagta tgaaccctgc   3480

ttgatgtaaa atggaaatag cacacaggca gatggccctg ggtttggact ttgatcttgc   3540

catcattccc cagtaaaacc tggggagttc tgcgttgagt ggacggactt attcctgtga   3600

agcggcataa tttgtctcca ttgaaaaatg gcattcactc ttacagatgg tgttcactgc   3660

aagccccaga agcatatggc atgtgttcac taagaggcct ttaatcctgg ggagtaaggg   3720

gcgaaggccc ttagacaacc atggctgctg tactgccgcc cagggtgggt ggccagtgag   3780

gactggcctt agcccagtgg acctgtggct tctctgaggc ccttgagtaa ctgaccacat   3840

ttggaggttt tgctggaaat gcctgacctc tcagtctggc tctgctgtgt agtccatagc   3900

ccagccagat gagcttgcag cctcatagga ggtcagcacc ttgcaaagat gcagtcacca   3960

tagatgtcca cgtagcagag actgacttag gatctgagat aaagcatcgg attgcaggaa   4020

taactgtcca aattagttct tcctcctcaa ctcataggag tagctgtgga cagaggaacc   4080

aacatctgcc acctctggca ttttctttct ttttttttct ttttgagacg gagtttcgct   4140

tttgtccccc aagctggagt acaatgacag gatctcggct cactgcaagc tctgcctccc   4200

gggttcaagc gattctcctg cctcagcctc ccaagtagct gggattacag gcacccacca   4260

cctcacccag ctaatttttg tattttcagt agagacgggg tttcaccatg ttggccaggc   4320

tactctcaaa ctcctgacct caggtgatct gcccacctcg gcttcccaaa gtgctggaat   4380

tacaggcctg agccacccca cccggcctat tttcttaaag gggaacaaat gatcttgaca   4440

acatattatt ccataaaacc agtttagggc acaggccagt tcctgattag aacacaggac   4500

ctgtgggagg gactatcaga gatgcaaaaa ttacttcaag atgagtttat tgttttcatt   4560

tgtattgcaa aagttagaag tcattttaca aattaaaaaa acattttttt cttggtagtc   4620

tttaaaaatt aggggattga aaggatccag gatgggcttt gtgtgtgtgt ctcagattct   4680

catttattag tgagcacacc tgtgtatata tataaatcac aaggagatca tcaagggaaa   4740

acattttgca tgtgtaaagc ttcatgaagt tctctttaaa aaataccaaa gcttgtttat   4800

ttctgataat taacctaagc ccttatgaaa ataaacaaaa tgaagggatt atgacaggta   4860

ttaccaaaaa caccaaaagg aacaaagggg cctgcgttaa aacctaattg ctaatgcttc   4920

acaactagga gagcatgccg tcttgatgtt taaaaaaccc agggtctcca cccttccttt   4980

gatttgtgca attctgtctt ccacagttcc ggagccttca gtgaggggta gctacatgcc   5040

ccatgcctgc cctttctttc cttctttgct cactttacta tgggtgtatt ttaatcttgt   5100

ataaaaatat gcatgaatga gtcatgcaca tgtatacgtt atgtatttga caagtggtgg   5160

tgaaacaaaa tcaaaacaga tttgatttgt gtttttgaaa tgtcagtaca ttttgtgcca   5220

ctaacactgt gatgtataaa agagctgttt gaatgccttt taatgttgtg ttttgtactc   5280

tggaatcata tggaaaaagt ttgatttgta atttcaatac atattttaaa tgtattgtgt   5340

cttacgtagt ttgtcccccc ctttagcagg gattcctttt taaagctatt ttggctggaa   5400

tacaggtgac ttttgtaaac cc                                            5422


<210>  7616
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  7616

Met Ala Val Gly Gln Glu Lys Gln Ala Cys Phe Leu Pro Lys Ser Ala 
1               5                   10                  15      


Val Thr Val Ala Ala Phe Lys Met Glu Glu Asp Asp Ala Pro Ile Lys 
            20                  25                  30          


Arg Cys Pro Lys Cys Lys Val Tyr Ile Glu Arg Asp Glu Gly Cys Ala 
        35                  40                  45              


Gln Met Met Cys Lys Asn Cys Lys His Ala Phe Cys Trp Tyr Cys Leu 
    50                  55                  60                  


Glu Ser Leu Asp Asp Asp Phe Leu Leu Ile His Tyr Asp Lys Gly Pro 
65                  70                  75                  80  


Cys Arg Asn Lys Leu Gly His Ser Arg Ala Ser Val Ile Trp His Arg 
                85                  90                  95      


Thr Gln Val Val Gly Ile Phe Ala Gly Phe Gly Leu Leu Leu Leu Val 
            100                 105                 110         


Ala Ser Pro Phe Leu Leu Leu Ala Thr Pro Phe Val Leu Cys Cys Lys 
        115                 120                 125             


Cys Lys Cys Ser Lys Gly Asp Asp Asp Pro Leu Pro Thr 
    130                 135                 140     


<210>  7617
<211>  5314
<212>  DNA
<213>  Homosapiens

<400>  7617
ggcgtcagag ccgcgcaccg cggacgagca ggcccaggca tccagtaccc tgctgactct     60

gacatgcccc cagcctcccc cagctctgca gggagccctg gtgccagaga ccttctccca    120

tttctcccta tgggtgcctg acctgagggc agagacatct gagtgtgtat aagcacagca    180

ggacaccagg acctggcctg aagacatttc ctctcctccc ctctggattt ctcagagtgc    240

ctgaaacagt atgttgagct cttgatcaaa gaaggattag aaactgcaat tagctgccca    300

gatgctgcct gccctaaaca gggccaccta caggagaacg agattgagtg catggttgca    360

gctgaaatta tgcaaagata taaaaagcta caatttgaaa gagaggtgct gtttgatccc    420

tgtcggactt ggtgcccggc gtccacctgc caagctgtgt gtcagctcca ggacgtgggg    480

ctgcagaccc cccagccagt gcagtgcaaa gcctgccgta tggaattctg ctccacctgc    540

aaagccagct ggcaccctgg ccagggctgc ccggagacca tgccgatcac cttcctcccc    600

ggggagacca gtgctgcttt caaaatggaa gaagatgacg cgcccatcaa gcgctgcccc    660

aagtgcaaag tctacatcga gcgagacgaa ggctgcgcgc agatgatgtg caagaactgc    720

aagcacgcct tctgctggta ctgcctggag tctctggacg atgatttcct tctgatacac    780

tacgataagg gaccctgccg gaacaagctg ggccactccc gggcatctgt gatctggcat    840

cggacacagg ttgtgggcat ttttgcagga tttgggctgc tgctcttggt ggcctcacct    900

ttcctactcc tggccactcc ctttgtactt tgctgcaagt gcaagtgcag taaaggtgac    960

gacgacccgt tacccaccta gaggaagcgc gatgctggaa cacatccctg cctccgggaa   1020

gtgtggctct cccccaaccc tccccaccgt ccccccttca ctaaacatct ttcttgcctt   1080

atgtgcccca ttgagcttca cagtgtcagg ctggacgccg tgatttcagg gacctatgtc   1140

acaatgttcg ctgaggcccc aggtgtggtg gggaggggag gcaggtgtgg gtagcgcaca   1200

tccccacaga tcaatctctg cagatgacag ggaggtgctg tgagaagtgc accaggcagc   1260

tttctctctg tggtagacta ggcatgtctg gggatggcct aagagacttt ctgctccttg   1320

gcttctagat ggcaccatgt tgtcagagaa gtcttttaag gactgccact ctcttcagac   1380

agaatctgat tattccagct tgagagaagc actctgttta tgacaactgt ttttattact   1440

aatggcattt agtaaaatcc tttttagaag gtattttttt tccaactgag tagtgaaaat   1500

caacaaggtg catataaacc atcctatgcc tttcttgaaa tgtgcatttt aagaagttat   1560

agttaaacga cttttcagga gatttagaaa gccttatgca ctctttgtgt ttttcttgaa   1620

acttgctgta gtaacttttt gaacgctgta agctgtgtac tgttataagt gtgcttccta   1680

tattgttgca tttccttgat aatattgacg tgtttaaagg aacatctcat ctccattaga   1740

tttgcctttt gttgttttct ctctttggtg attcagctca gctcatgggc ctcatccctt   1800

ctctcccagg tagcagaaaa cgctttttat tgtattcaat cccactgctt tgctcggcaa   1860

tggttctcct ccgaattgct gccgtctggc ctctggcctc agtcttcaga tagacagtaa   1920

gaagaaagca gcctcattga tccgcagatg taggggcctc ttggcagagg ctggaggact   1980

ctgggggcta gggaagagcc tgccagattt tcacattttt aaaatgttct agtcattttg   2040

agaaatcata tatcttacac agttccaagt cctgttgcta accgttttgc tcttgttggg   2100

gaaaagaacc tcccatttca cttcgtttta acgtggggat tttaccactt gatcttttac   2160

agggctgtct gtgaccattt ccatggcagc aggatgcagg gattaataag gacacataca   2220

cattattcca ccaattgact ttgaaaagtg gagaaagtgt attctttaaa gagaatttac   2280

ttctaaaagc cacaggtgct tttacaaagc aaactgcatt gaatttaaaa cttctaaaaa   2340

taacaggcaa atattgtagc tatattacag tgggatttta aaaatcttgt taaacattct   2400

ataaagaagt aaaacaaaat ccttttatct cagttatttg cccatcacaa gcacattttt   2460

aaaatgttgc tttgtgtgtg tttgacttct gcatttgagt atcagtctca ggtcctagtt   2520

tactttccct ggttggaaat ttatttctta tttcctaaca ttgaattcgt tagaaaaaac   2580

agcgtcacct cactcttcac ctgtcatgtt gattttcctt atgaacccga agccatttag   2640

aaaatccctg tgtgtcaaaa ttacattcaa aaagctctcc ttgtaattgc aagtttagta   2700

actcagtaag aacatgcctg cgactccctt tctggatgga acctgggctg tggctctctg   2760

tcgtttgtgg tgctgtgatg gtgtctactg ttagaatagc ttttctggag gtgggtggca   2820

actccacgcg ggagtcattg gctgggcttg agccctcagc ctgtgatatg tggatgcagc   2880

tgtccagcca ctgcccttta acatgcccag cacacatggg aggcctgtgg ccctgtgtcc   2940

agtggcccac aggacacgcc tccaccatat gctcatcctt cctgcctgaa attgctgctg   3000

cccatcgcat gagcccacac agtagcaccc ccgtccttag gatgagagtc agagcctttg   3060

gaaaggctgc atccccaggg ctagagctca gatgacctta tttctagagg gacaggctgt   3120

tctgttggaa gagtctctgg cccagtcatg cacatctgta gccccagcca tccttgtgcc   3180

ttcacctctg atgtgtttca caagcacgta gttcaaccca gatagggacc acagagattc   3240

tggggccagc caggggcagt caaattggca cctactggct ctgacttttt gtatgaagca   3300

tgcctcagtt tcctcatttt gatctagata taaaattaaa attgtccatt tcctatataa   3360

ataccagcaa gatcactctg agatacataa actcgcattt ccttctgttt tagtaaggag   3420

tgccagactt atctttgatg ggaatacagt atgaaccctg cttgatgtaa aatggaaata   3480

gcacacaggc agatggccct gggtttggac tttgatcttg ccatcattcc ccagtaaaac   3540

ctggggagtt ctgcgttgag tggacggact tattcctgtg aagcggcata atttgtctcc   3600

attgaaaaat ggcattcact cttacagatg gtgttcactg caagccccag aagcatatgg   3660

catgtgttca ctaagaggcc tttaatcctg gggagtaagg ggcgaaggcc cttagacaac   3720

catggctgct gtactgccgc ccagggtggg tggccagtga ggactggcct tagcccagtg   3780

gacctgtggc ttctctgagg cccttgagta actgaccaca tttggaggtt ttgctggaaa   3840

tgcctgacct ctcagtctgg ctctgctgtg tagtccatag cccagccaga tgagcttgca   3900

gcctcatagg aggtcagcac cttgcaaaga tgcagtcacc atagatgtcc acgtagcaga   3960

gactgactta ggatctgaga taaagcatcg gattgcagga ataactgtcc aaattagttc   4020

ttcctcctca actcatagga gtagctgtgg acagaggaac caacatctgc cacctctggc   4080

attttctttc tttttttttc tttttgagac ggagtttcgc ttttgtcccc caagctggag   4140

tacaatgaca ggatctcggc tcactgcaag ctctgcctcc cgggttcaag cgattctcct   4200

gcctcagcct cccaagtagc tgggattaca ggcacccacc acctcaccca gctaattttt   4260

gtattttcag tagagacggg gtttcaccat gttggccagg ctactctcaa actcctgacc   4320

tcaggtgatc tgcccacctc ggcttcccaa agtgctggaa ttacaggcct gagccacccc   4380

acccggccta ttttcttaaa ggggaacaaa tgatcttgac aacatattat tccataaaac   4440

cagtttaggg cacaggccag ttcctgatta gaacacagga cctgtgggag ggactatcag   4500

agatgcaaaa attacttcaa gatgagttta ttgttttcat ttgtattgca aaagttagaa   4560

gtcattttac aaattaaaaa aacatttttt tcttggtagt ctttaaaaat taggggattg   4620

aaaggatcca ggatgggctt tgtgtgtgtg tctcagattc tcatttatta gtgagcacac   4680

ctgtgtatat atataaatca caaggagatc atcaagggaa aacattttgc atgtgtaaag   4740

cttcatgaag ttctctttaa aaaataccaa agcttgttta tttctgataa ttaacctaag   4800

cccttatgaa aataaacaaa atgaagggat tatgacaggt attaccaaaa acaccaaaag   4860

gaacaaaggg gcctgcgtta aaacctaatt gctaatgctt cacaactagg agagcatgcc   4920

gtcttgatgt ttaaaaaacc cagggtctcc acccttcctt tgatttgtgc aattctgtct   4980

tccacagttc cggagccttc agtgaggggt agctacatgc cccatgcctg ccctttcttt   5040

ccttctttgc tcactttact atgggtgtat tttaatcttg tataaaaata tgcatgaatg   5100

agtcatgcac atgtatacgt tatgtatttg acaagtggtg gtgaaacaaa atcaaaacag   5160

atttgatttg tgtttttgaa atgtcagtac attttgtgcc actaacactg tgatgtataa   5220

aagagctgtt tgaatgcctt ttaatgttgt gttttgtact ctggaatcat atggaaaaag   5280

tttgatttgt aatttcaata catattttaa atgt                               5314


<210>  7618
<211>  209
<212>  PRT
<213>  Homosapiens

<400>  7618

Met Val Ala Ala Glu Ile Met Gln Arg Tyr Lys Lys Leu Gln Phe Glu 
1               5                   10                  15      


Arg Glu Val Leu Phe Asp Pro Cys Arg Thr Trp Cys Pro Ala Ser Thr 
            20                  25                  30          


Cys Gln Ala Val Cys Gln Leu Gln Asp Val Gly Leu Gln Thr Pro Gln 
        35                  40                  45              


Pro Val Gln Cys Lys Ala Cys Arg Met Glu Phe Cys Ser Thr Cys Lys 
    50                  55                  60                  


Ala Ser Trp His Pro Gly Gln Gly Cys Pro Glu Thr Met Pro Ile Thr 
65                  70                  75                  80  


Phe Leu Pro Gly Glu Thr Ser Ala Ala Phe Lys Met Glu Glu Asp Asp 
                85                  90                  95      


Ala Pro Ile Lys Arg Cys Pro Lys Cys Lys Val Tyr Ile Glu Arg Asp 
            100                 105                 110         


Glu Gly Cys Ala Gln Met Met Cys Lys Asn Cys Lys His Ala Phe Cys 
        115                 120                 125             


Trp Tyr Cys Leu Glu Ser Leu Asp Asp Asp Phe Leu Leu Ile His Tyr 
    130                 135                 140                 


Asp Lys Gly Pro Cys Arg Asn Lys Leu Gly His Ser Arg Ala Ser Val 
145                 150                 155                 160 


Ile Trp His Arg Thr Gln Val Val Gly Ile Phe Ala Gly Phe Gly Leu 
                165                 170                 175     


Leu Leu Leu Val Ala Ser Pro Phe Leu Leu Leu Ala Thr Pro Phe Val 
            180                 185                 190         


Leu Cys Cys Lys Cys Lys Cys Ser Lys Gly Asp Asp Asp Pro Leu Pro 
        195                 200                 205             


Thr 
    


<210>  7619
<211>  5403
<212>  DNA
<213>  Homosapiens

<400>  7619
ggcgtcagag ccgcgcaccg cggacgagca ggcccaggca tccagtaccc tgctgactct     60

gacatgcccc cagcctcccc cagctctgca gggagccctg gtgccagaga ccttctccca    120

tttctcccta tgggtgcctg acctgagggc agagacatct gagtgtgtat aagcacagca    180

ggacaccagg acctggcctg aagacatttc ctctcctccc ctctggattt ctcagagtgc    240

ctgaaacagt atgttgagct cttgatcaaa gaaggattag aaactgcaat tagctgccca    300

gatgctgcct gccctaaaca gggccaccta caggagaacg agattgagtg catggttgca    360

gctgaaatta tgcaaagata taaaaagcta caatttgaaa gagaggtgct gtttgatccc    420

tgtcggactt ggtgcccggc gtccacctgc caagctgtgt gtcagctcca ggacgtgggg    480

ctgcagaccc cccagccagt gcagtgcaaa gcctgccgta tggaattctg ctccacctgc    540

aaagccagct ggcaccctgg ccagggctgc ccggagacca tgccgatcac cttcctcccc    600

ggggagacca gtgctgcttt caaaatggaa gaagatgacg cgcccatcaa gcgctgcccc    660

aagtgcaaag tctacatcga gcgagacgaa ggctgcgcgc agatgatgtg caagaactgc    720

aagcacgcct tctgctggta ctgcctggag tctctggacg atgatttcct tctgatacac    780

tacgataagg gaccctgccg gaacaagctg ggccactccc gggcatctgt gatctggcat    840

cggacacagg ttgtgggcat ttttgcagga tttgggctgc tgctcttggt ggcctcacct    900

ttcctactcc tggccactcc ctttgtactt tgctgcaagt gcaagtgcag taaaggtgac    960

gacgacccgt tacccaccta gaggaagcgc gatgctggaa cacatccctg cctccgggaa   1020

gtgtggctct cccccaaccc tccccaccgt ccccccttca ctaaacatct ttcttgcctt   1080

atgtgcccca ttgagcttca cagtgtcagg ctggacgccg tgatttcagg gacctatgtc   1140

acaatgttcg ctgaggcccc aggtgtggtg gggaggggag gcaggtgtgg gtagcgcaca   1200

tccccacaga tcaatctctg cagatgacag ggaggtgctg tgagaagtgc accaggcagc   1260

tttctctctg tggtagacta ggcatgtctg gggatggcct aagagacttt ctgctccttg   1320

gcttctagat ggcaccatgt tgtcagagaa gtcttttaag gactgccact ctcttcagac   1380

agaatctgat tattccagct tgagagaagc actctgttta tgacaactgt ttttattact   1440

aatggcattt agtaaaatcc tttttagaag gtattttttt tccaactgag tagtgaaaat   1500

caacaaggtg catataaacc atcctatgcc tttcttgaaa tgtgcatttt aagaagttat   1560

agttaaacga cttttcagga gatttagaaa gccttatgca ctctttgtgt ttttcttgaa   1620

acttgctgta gtaacttttt gaacgctgta agctgtgtac tgttataagt gtgcttccta   1680

tattgttgca tttccttgat aatattgacg tgtttaaagg aacatctcat ctccattaga   1740

tttgcctttt gttgttttct ctctttggtg attcagctca gctcatgggc ctcatccctt   1800

ctctcccagg tagcagaaaa cgctttttat tgtattcaat cccactgctt tgctcggcaa   1860

tggttctcct ccgaattgct gccgtctggc ctctggcctc agtcttcaga tagacagtaa   1920

gaagaaagca gcctcattga tccgcagatg taggggcctc ttggcagagg ctggaggact   1980

ctgggggcta gggaagagcc tgccagattt tcacattttt aaaatgttct agtcattttg   2040

agaaatcata tatcttacac agttccaagt cctgttgcta accgttttgc tcttgttggg   2100

gaaaagaacc tcccatttca cttcgtttta acgtggggat tttaccactt gatcttttac   2160

agggctgtct gtgaccattt ccatggcagc aggatgcagg gattaataag gacacataca   2220

cattattcca ccaattgact ttgaaaagtg gagaaagtgt attctttaaa gagaatttac   2280

ttctaaaagc cacaggtgct tttacaaagc aaactgcatt gaatttaaaa cttctaaaaa   2340

taacaggcaa atattgtagc tatattacag tgggatttta aaaatcttgt taaacattct   2400

ataaagaagt aaaacaaaat ccttttatct cagttatttg cccatcacaa gcacattttt   2460

aaaatgttgc tttgtgtgtg tttgacttct gcatttgagt atcagtctca ggtcctagtt   2520

tactttccct ggttggaaat ttatttctta tttcctaaca ttgaattcgt tagaaaaaac   2580

agcgtcacct cactcttcac ctgtcatgtt gattttcctt atgaacccga agccatttag   2640

aaaatccctg tgtgtcaaaa ttacattcaa aaagctctcc ttgtaattgc aagtttagta   2700

actcagtaag aacatgcctg cgactccctt tctggatgga acctgggctg tggctctctg   2760

tcgtttgtgg tgctgtgatg gtgtctactg ttagaatagc ttttctggag gtgggtggca   2820

actccacgcg ggagtcattg gctgggcttg agccctcagc ctgtgatatg tggatgcagc   2880

tgtccagcca ctgcccttta acatgcccag cacacatggg aggcctgtgg ccctgtgtcc   2940

agtggcccac aggacacgcc tccaccatat gctcatcctt cctgcctgaa attgctgctg   3000

cccatcgcat gagcccacac agtagcaccc ccgtccttag gatgagagtc agagcctttg   3060

gaaaggctgc atccccaggg ctagagctca gatgacctta tttctagagg gacaggctgt   3120

tctgttggaa gagtctctgg cccagtcatg cacatctgta gccccagcca tccttgtgcc   3180

ttcacctctg atgtgtttca caagcacgta gttcaaccca gatagggacc acagagattc   3240

tggggccagc caggggcagt caaattggca cctactggct ctgacttttt gtatgaagca   3300

tgcctcagtt tcctcatttt gatctagata taaaattaaa attgtccatt tcctatataa   3360

ataccagcaa gatcactctg agatacataa actcgcattt ccttctgttt tagtaaggag   3420

tgccagactt atctttgatg ggaatacagt atgaaccctg cttgatgtaa aatggaaata   3480

gcacacaggc agatggccct gggtttggac tttgatcttg ccatcattcc ccagtaaaac   3540

ctggggagtt ctgcgttgag tggacggact tattcctgtg aagcggcata atttgtctcc   3600

attgaaaaat ggcattcact cttacagatg gtgttcactg caagccccag aagcatatgg   3660

catgtgttca ctaagaggcc tttaatcctg gggagtaagg ggcgaaggcc cttagacaac   3720

catggctgct gtactgccgc ccagggtggg tggccagtga ggactggcct tagcccagtg   3780

gacctgtggc ttctctgagg cccttgagta actgaccaca tttggaggtt ttgctggaaa   3840

tgcctgacct ctcagtctgg ctctgctgtg tagtccatag cccagccaga tgagcttgca   3900

gcctcatagg aggtcagcac cttgcaaaga tgcagtcacc atagatgtcc acgtagcaga   3960

gactgactta ggatctgaga taaagcatcg gattgcagga ataactgtcc aaattagttc   4020

ttcctcctca actcatagga gtagctgtgg acagaggaac caacatctgc cacctctggc   4080

attttctttc tttttttttc tttttgagac ggagtttcgc ttttgtcccc caagctggag   4140

tacaatgaca ggatctcggc tcactgcaag ctctgcctcc cgggttcaag cgattctcct   4200

gcctcagcct cccaagtagc tgggattaca ggcacccacc acctcaccca gctaattttt   4260

gtattttcag tagagacggg gtttcaccat gttggccagg ctactctcaa actcctgacc   4320

tcaggtgatc tgcccacctc ggcttcccaa agtgctggaa ttacaggcct gagccacccc   4380

acccggccta ttttcttaaa ggggaacaaa tgatcttgac aacatattat tccataaaac   4440

cagtttaggg cacaggccag ttcctgatta gaacacagga cctgtgggag ggactatcag   4500

agatgcaaaa attacttcaa gatgagttta ttgttttcat ttgtattgca aaagttagaa   4560

gtcattttac aaattaaaaa aacatttttt tcttggtagt ctttaaaaat taggggattg   4620

aaaggatcca ggatgggctt tgtgtgtgtg tctcagattc tcatttatta gtgagcacac   4680

ctgtgtatat atataaatca caaggagatc atcaagggaa aacattttgc atgtgtaaag   4740

cttcatgaag ttctctttaa aaaataccaa agcttgttta tttctgataa ttaacctaag   4800

cccttatgaa aataaacaaa atgaagggat tatgacaggt attaccaaaa acaccaaaag   4860

gaacaaaggg gcctgcgtta aaacctaatt gctaatgctt cacaactagg agagcatgcc   4920

gtcttgatgt ttaaaaaacc cagggtctcc acccttcctt tgatttgtgc aattctgtct   4980

tccacagttc cggagccttc agtgaggggt agctacatgc cccatgcctg ccctttcttt   5040

ccttctttgc tcactttact atgggtgtat tttaatcttg tataaaaata tgcatgaatg   5100

agtcatgcac atgtatacgt tatgtatttg acaagtggtg gtgaaacaaa atcaaaacag   5160

atttgatttg tgtttttgaa atgtcagtac attttgtgcc actaacactg tgatgtataa   5220

aagagctgtt tgaatgcctt ttaatgttgt gttttgtact ctggaatcat atggaaaaag   5280

tttgatttgt aatttcaata catattttaa atgtattgtg tcttacgtag tttgtccccc   5340

cctttagcag ggattccttt ttaaagctat tttggctgga atacaggtga cttttgtaaa   5400

ccc                                                                 5403


<210>  7620
<211>  209
<212>  PRT
<213>  Homosapiens

<400>  7620

Met Val Ala Ala Glu Ile Met Gln Arg Tyr Lys Lys Leu Gln Phe Glu 
1               5                   10                  15      


Arg Glu Val Leu Phe Asp Pro Cys Arg Thr Trp Cys Pro Ala Ser Thr 
            20                  25                  30          


Cys Gln Ala Val Cys Gln Leu Gln Asp Val Gly Leu Gln Thr Pro Gln 
        35                  40                  45              


Pro Val Gln Cys Lys Ala Cys Arg Met Glu Phe Cys Ser Thr Cys Lys 
    50                  55                  60                  


Ala Ser Trp His Pro Gly Gln Gly Cys Pro Glu Thr Met Pro Ile Thr 
65                  70                  75                  80  


Phe Leu Pro Gly Glu Thr Ser Ala Ala Phe Lys Met Glu Glu Asp Asp 
                85                  90                  95      


Ala Pro Ile Lys Arg Cys Pro Lys Cys Lys Val Tyr Ile Glu Arg Asp 
            100                 105                 110         


Glu Gly Cys Ala Gln Met Met Cys Lys Asn Cys Lys His Ala Phe Cys 
        115                 120                 125             


Trp Tyr Cys Leu Glu Ser Leu Asp Asp Asp Phe Leu Leu Ile His Tyr 
    130                 135                 140                 


Asp Lys Gly Pro Cys Arg Asn Lys Leu Gly His Ser Arg Ala Ser Val 
145                 150                 155                 160 


Ile Trp His Arg Thr Gln Val Val Gly Ile Phe Ala Gly Phe Gly Leu 
                165                 170                 175     


Leu Leu Leu Val Ala Ser Pro Phe Leu Leu Leu Ala Thr Pro Phe Val 
            180                 185                 190         


Leu Cys Cys Lys Cys Lys Cys Ser Lys Gly Asp Asp Asp Pro Leu Pro 
        195                 200                 205             


Thr 
    


<210>  7621
<211>  2282
<212>  DNA
<213>  Homosapiens

<400>  7621
ttatagcggc tgcataagct taactgcgca gagctatact gctttttgaa atactaactt     60

gcaagttcag caacagctaa gaaaacaatc ctagacttgg aaattgaaag attggaagag    120

aagtggaggg attcctttgg aaccctttac gtacgtatgt gtaaggaatt gtaggcatcc    180

agtaccctgc tgactctgac atgcccccag cctcccccag ctctgcaggg agccctggtg    240

ccagagacct tctcccattt ctccctatgg gtgcctgacc tgagggcaga gacatctgag    300

tgtgtataag cacagcagga caccaggacc tggcctgaag acatttcctc tcctcccctc    360

tggatttctc agaggttgcc cacctctgtg tcaatgcagc ctgctcttaa tgactccagc    420

tctctaggct ggacgcagtg gctcacaccg gtaatcccag cactttggga ggctgaagcc    480

ggtggatcac ctgaggtcag gagcttgaga ccagcctggc caacatggtg aaactccgtg    540

tcttctaaaa aaatacaaaa attagagcgg catggtggcg ggcgcctgta atcccagcta    600

ctcgggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagcca    660

agatcgtgcc actgcattgc agtctgggaa acaagagcaa aactgcgtct caaaaaaaat    720

tttcttctca gtactgcttt aatggcatct cataagtttt cttaaataat attctcatta    780

atgtttagtt ctacatattt ttaaaattac atatttttct ataacccatg agttactgat    840

aagtctttca aaattttcca acgtgtggga tctttttatt atcaatatct atcttaattg    900

cattgaggtc agaacacatg gtctgctgag ttgttcttta tgtcccagta taatgtcagc    960

ttttgtgaat gttctgtgtc tttttgagaa aactgtgaat tcccagttta ttggttctgg   1020

gtttttacaa tctattacat caagattgtt tgcagtacct ttcatatttt ctacattttc   1080

actagttttg catgtttgcc attttaaagt catatataat gagttttctc agtgcgttgg   1140

tgtacttggc atttttctca gtaagtatca tttttgcttt atatattttg aagttatttg   1200

ttgtatacaa acttaaaatt tatggattct taatgaatta agacttttat aatgtattac   1260

cttctttttc tctagttagg ctttattctt taaagcctgt tttgtcgata gctttctttt   1320

ggttggcatt tttcttgatc acttttctcc atcctttgac ttctaattta tccaatttct   1380

tatactttta ggtatattta tctgttttta aaatttaatt ttaccatttc ttggctatca   1440

agcttaatcc atttattttt tatgacttta atatatttgg atttttttct tcaaatgctt   1500

ttatgccgtt ttctgttttt taaatgcata tttgtttctt tatagtatta cttctttttt   1560

tcttttataa tttggaagtt atacattctg tttctcttct cttagtagac agcactgata   1620

ttttcctgtg tgcacagaaa gtaaaaaaaa agaaagcctt aaattctcag tttctaaaaa   1680

ccctaagagc cttagaattc tgtagtccac ttacaggttt ataagctacg atgcttattc   1740

gttttttagt tcaatctgtt ttaactgggc tttagttatt ttctgctggg aagggtcttg   1800

atagaatcta attcatcata atgagggaag tggatgtctg caattactga tttttgttgc   1860

tgctgaagac atgggtggcc ccttggctca aaacctgttt catcatttgg atggagcatc   1920

aaagaagatg ggaactctcc actgataggt ttttcatgac acttatgtag attttcaatt   1980

aagtaggcac aagagatttt cagtgtagaa aaagtatttt atgattcatg tgaactagac   2040

aaaggactga gatcttacgt gcgtgtaagt ccagggccat gtgacacact ttgcaaatgt   2100

ggaaagaaca cagcactggt aaacttagct gtcgtcaagt tgatattcta gattattttc   2160

attctataat gttttaaacc ttattttctg tagtaaacat atattaacat ttataaggtg   2220

acccacacac taccgttttt aaaaagatag tgttattttt aaaatagaca cctctttgac   2280

ct                                                                  2282


<210>  7622
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  7622

Met Gln Pro Ala Leu Asn Asp Ser Ser Ser Leu Gly Trp Thr Gln Trp 
1               5                   10                  15      


Leu Thr Pro Val Ile Pro Ala Leu Trp Glu Ala Glu Ala Gly Gly Ser 
            20                  25                  30          


Pro Glu Val Arg Ser Leu Arg Pro Ala Trp Pro Thr Trp 
        35                  40                  45  


<210>  7623
<211>  423
<212>  DNA
<213>  Homosapiens

<400>  7623
ctacattcca ggcccgcttc aagaattgat gtgcaaccca gcgtagggaa gaactgcttc     60

tggactgcac ctgaggcagc accaccggca acggagcccc gccacctgct gtacccgtcc    120

accttctctg gttgacctcc ctggggccag acagcccact cagagtccgt gctccctcct    180

atggagatga aggagctgtg tccacaggcg tgcacacagg gagaacgccg tgggaacctg    240

caggcagaga ctgggggtgc atctaccagc caaggaacac ccaggactgc cagcagtacc    300

aggaagttgc agagcaacac gggcatcctc cttaccgctc tcagaagatt ccagccctgc    360

agatacctga accttcagtt tccaacctcc agacctggaa gacagtaaag ctctgttgtt    420

gta                                                                  423


<210>  7624
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  7624

Met Glu Met Lys Glu Leu Cys Pro Gln Ala Cys Thr Gln Gly Glu Arg 
1               5                   10                  15      


Arg Gly Asn Leu Gln Ala Glu Thr Gly Gly Ala Ser Thr Ser Gln Gly 
            20                  25                  30          


Thr Pro Arg Thr Ala Ser Ser Thr Arg Lys Leu Gln Ser Asn Thr Gly 
        35                  40                  45              


Ile Leu Leu Thr Ala Leu Arg Arg Phe Gln Pro Cys Arg Tyr Leu Asn 
    50                  55                  60                  


Leu Gln Phe Pro Thr Ser Arg Pro Gly Arg Gln 
65                  70                  75  


<210>  7625
<211>  3544
<212>  DNA
<213>  Homosapiens

<400>  7625
gtcccagctc tgtcctggct ggctgggccc cacctcaacc tctgctgtgc agcttttcct     60

tctaggagag atggagccag caggagagaa agatgagcca ttgagtgtaa aacacgggag    120

gccaatgaag tgtccctctc aggagagccc ctatctgttc agctacagaa acagcaacta    180

cctgaccaga ctgcagaaac cccaagacaa gcttgaggta agagaaggag cggaaatcag    240

atgtcctgac aaagacccct ccgatacggt tcccacctca gttcataggc tgaagccggc    300

tgacatcaac gtaattggag ccctgggtga ctctctcacg gcaggcaatg gggccgggtc    360

cacacctggg aacgtcttgg acgtcttgac tcagtaccga ggcctgtcct ggagcgtcgg    420

cggagatgag aacatcggca ccgttaccac cctggcgaac atcctccggg aattcaaccc    480

ttccctgaag ggcttctctg ttggcactgg gaaagaaacc agtcctaatg ccttcttaaa    540

ccaggctgtg gcaggaggcc gagctgagga tctacctgtc caggccagga ggctggtgga    600

cctgatgaag aatgacacga ggatacactt tcaggaagac tggaagataa taaccctgtt    660

tataggcggc aatgacctct gtgatttctg caatgatctg gtccactatt ctccccagaa    720

cttcacagac aacattggaa aggccctgga catcctccat gctgaggttc ctcgggcatt    780

tgtgaacctg gtgacggtgc ttgagatcgt caacctgagg gagctgtacc aggagaaaaa    840

agtctactgc ccaaggatga tcctcaggtc tctgtgtccc tgtgtcctga agtttgatga    900

taactcaaca gaacttgcta ccctcatcga attcaacaag aagtttcagg agaagaccca    960

ccaactgatt gagagtgggc gatatgacac aagggaagat tttactgtgg ttgtgcagcc   1020

gttctttgaa aacgtggaca tgccaaagac ctcggaagga ttgcctgaca actctttctt   1080

cgctcctgac tgtttccact tcagcagcaa gtctcactcc cgagcagcca gtgctctctg   1140

gaacaatatg ctggagcctg ttggccagaa gacgactcgt cataagtttg aaaacaagat   1200

caatatcaca tgtccgaacc aggtccagcc gtttctgagg acctacaaga acagcatgca   1260

gggtcatggg acctggctgc catgcaggga cagagcccct tctgccttgc accctacctc   1320

agtgcatgcc ctgagacctg cagacatcca agttgtggct gctctggggg attctctgac   1380

cgctggcaat ggaattggct ccaaaccaga cgacctcccc gatgtcacca cacagtatcg   1440

gggactgtca tacagagaaa gtaaaccagg gttcttatca gactcctggg tcagcaaatc   1500

caacaggaaa tgcaccagaa aagcaccaaa tccctgaatc ttcacctccc cgcttgcatg   1560

tatacgtgta cacgtggtgt tcctacgtct ctgtttactg tctttatgtg tttattcatg   1620

ttgtcttgta gtcacacagc tgcctttaca tatatgtaca catctgcaca gaaaacctct   1680

gaaacccatc gcacacttcg agaggccata accaagacac aatcacaatc agccatgtct   1740

tgaaagatta gcaattcgac aagaggaaag ggtgagaaag ggcatcccga acacggaagt   1800

ggagaagctc agggtgtgtc aggcgagcgg ttgcgtgtag atattctcaa gtttctttct   1860

ctcctaataa agttctcatt cctgtaggct tcaaagtaag tggcgagtag ctcagaattt   1920

acctgggaaa acaactagaa cgaagctggc cacaaggggg cagcgtgcta atgagtggcg   1980

gagccaggac agcacctttg ctgccgcctc ccttttcttc tgagtcagtt tgcttcctgg   2040

ggaagtgaca gggagcaggg agggggtgat caagactgtg aaggttctct ggccagacct   2100

gagcagagtc ccagagagga tgggtttcca gggcgagagg gaggcgccat cactcggcct   2160

gtaccaccca caacgaggac ctaggttgtc cttagcatga ggacatcaac ctctcaagaa   2220

cagaggtcag tgccttcctg cgccaaggtc cctgcgtttc cacaagtcct tggtcaggta   2280

cctggtccta acaggctgcc atggaacaaa tcagagcctc actgactcac cattctgctc   2340

ctaatgaggc tacaagaaaa aaaaccagag gagagaaagc agagcttatt acaatcagga   2400

aagagcatga ggttctggca gctgcacttg gtctcagcta aagaaggcaa tgacctcata   2460

cgatagcatg ggaaacaaaa atcaagcaga cgaaccacat tgcaggtgat agatacgcga   2520

cgtgcacctg gtggggcagc ctggggaagt gaggtgatgt gccctacttt aaaacagatc   2580

gaccagctgg gctcctggga ttcagatatg aaccagcagt cctctactaa aagtttcttt   2640

ctgcagcgat gggaaaattc agccattgct ctgtttcttc caacaagtga agtccattac   2700

agcctaatgt ctcaatcttt tagttctagc tctaaggcct caggttcaat ggctgctgtc   2760

cctttaaacc cttcatttgt cctaaatgtt tcaaatagct gcccccaaat gcacgtgtgt   2820

taaagatgga agctctaggt cggggtctga gagacagctt gacacttggt agaatacata   2880

gactactgtg tctcaaagtg tgttccatgg aacattaact ccagacctgt tcctggagaa   2940

gagaaaatcc tttgtatctg agggggaaac attaccataa ccttcctttg gggaattcat   3000

gtgtgtatta gcatattaaa ggctctcata aggcctgcaa tgcagaaatc tatttaagtt   3060

ttatctgttt aacccaatgt ttcccttaat tccagaacat tttctttgtt cataacacct   3120

gttaacacct cctgaaagtg ttcacgtagt agacttatct gagaaaagca atttttgagc   3180

cgttaaagct tctagattgg acaaactagg caattaatga tactagatca attcagaatg   3240

caatttgagc ctcttccccc tgggaaacaa agtgaaaaga gtggatctca tggaattagg   3300

ggagaagtag acccagaatt catggggggt gggtggctgt gaacaggacc tgcagaagag   3360

gctcggctgt gaatatttcc aaggcccctt gacctgtgag attctgtagt gaacggttcc   3420

agctttggcc agcttaacaa tgtgctgggc cccaaggtct tgagagcatt gccttttctt   3480

ccattgaaat aagttcgctt gtttgggacc attcaaagga tcaaaataaa atttacttac   3540

caaa                                                                3544


<210>  7626
<211>  488
<212>  PRT
<213>  Homosapiens

<400>  7626

Met Glu Pro Ala Gly Glu Lys Asp Glu Pro Leu Ser Val Lys His Gly 
1               5                   10                  15      


Arg Pro Met Lys Cys Pro Ser Gln Glu Ser Pro Tyr Leu Phe Ser Tyr 
            20                  25                  30          


Arg Asn Ser Asn Tyr Leu Thr Arg Leu Gln Lys Pro Gln Asp Lys Leu 
        35                  40                  45              


Glu Val Arg Glu Gly Ala Glu Ile Arg Cys Pro Asp Lys Asp Pro Ser 
    50                  55                  60                  


Asp Thr Val Pro Thr Ser Val His Arg Leu Lys Pro Ala Asp Ile Asn 
65                  70                  75                  80  


Val Ile Gly Ala Leu Gly Asp Ser Leu Thr Ala Gly Asn Gly Ala Gly 
                85                  90                  95      


Ser Thr Pro Gly Asn Val Leu Asp Val Leu Thr Gln Tyr Arg Gly Leu 
            100                 105                 110         


Ser Trp Ser Val Gly Gly Asp Glu Asn Ile Gly Thr Val Thr Thr Leu 
        115                 120                 125             


Ala Asn Ile Leu Arg Glu Phe Asn Pro Ser Leu Lys Gly Phe Ser Val 
    130                 135                 140                 


Gly Thr Gly Lys Glu Thr Ser Pro Asn Ala Phe Leu Asn Gln Ala Val 
145                 150                 155                 160 


Ala Gly Gly Arg Ala Glu Asp Leu Pro Val Gln Ala Arg Arg Leu Val 
                165                 170                 175     


Asp Leu Met Lys Asn Asp Thr Arg Ile His Phe Gln Glu Asp Trp Lys 
            180                 185                 190         


Ile Ile Thr Leu Phe Ile Gly Gly Asn Asp Leu Cys Asp Phe Cys Asn 
        195                 200                 205             


Asp Leu Val His Tyr Ser Pro Gln Asn Phe Thr Asp Asn Ile Gly Lys 
    210                 215                 220                 


Ala Leu Asp Ile Leu His Ala Glu Val Pro Arg Ala Phe Val Asn Leu 
225                 230                 235                 240 


Val Thr Val Leu Glu Ile Val Asn Leu Arg Glu Leu Tyr Gln Glu Lys 
                245                 250                 255     


Lys Val Tyr Cys Pro Arg Met Ile Leu Arg Ser Leu Cys Pro Cys Val 
            260                 265                 270         


Leu Lys Phe Asp Asp Asn Ser Thr Glu Leu Ala Thr Leu Ile Glu Phe 
        275                 280                 285             


Asn Lys Lys Phe Gln Glu Lys Thr His Gln Leu Ile Glu Ser Gly Arg 
    290                 295                 300                 


Tyr Asp Thr Arg Glu Asp Phe Thr Val Val Val Gln Pro Phe Phe Glu 
305                 310                 315                 320 


Asn Val Asp Met Pro Lys Thr Ser Glu Gly Leu Pro Asp Asn Ser Phe 
                325                 330                 335     


Phe Ala Pro Asp Cys Phe His Phe Ser Ser Lys Ser His Ser Arg Ala 
            340                 345                 350         


Ala Ser Ala Leu Trp Asn Asn Met Leu Glu Pro Val Gly Gln Lys Thr 
        355                 360                 365             


Thr Arg His Lys Phe Glu Asn Lys Ile Asn Ile Thr Cys Pro Asn Gln 
    370                 375                 380                 


Val Gln Pro Phe Leu Arg Thr Tyr Lys Asn Ser Met Gln Gly His Gly 
385                 390                 395                 400 


Thr Trp Leu Pro Cys Arg Asp Arg Ala Pro Ser Ala Leu His Pro Thr 
                405                 410                 415     


Ser Val His Ala Leu Arg Pro Ala Asp Ile Gln Val Val Ala Ala Leu 
            420                 425                 430         


Gly Asp Ser Leu Thr Ala Gly Asn Gly Ile Gly Ser Lys Pro Asp Asp 
        435                 440                 445             


Leu Pro Asp Val Thr Thr Gln Tyr Arg Gly Leu Ser Tyr Arg Glu Ser 
    450                 455                 460                 


Lys Pro Gly Phe Leu Ser Asp Ser Trp Val Ser Lys Ser Asn Arg Lys 
465                 470                 475                 480 


Cys Thr Arg Lys Ala Pro Asn Pro 
                485             


<210>  7627
<211>  928
<212>  DNA
<213>  Homosapiens

<400>  7627
ctgattgaga gtgggcgata tgacacaagg gaagatttta ctgtggttgt gcagccgttc     60

tttgaaaacg tggacatgcc aaagacctcg gaaggattgc ctgacaactc tttcttcgct    120

cctgactgtt tccacttcag cagcaagtct cactcccgag cagccagtgc tctctggaac    180

aatatgctgg agcctgttgg ccagaagacg actcgtcata agtttgaaaa caagatcaat    240

atcacatgtc cgaaccaggt ccagccgttt ctgaggacct acaagaacag catgcagggt    300

catgggacct ggctgccatg cagggacaga gccccttctg ccttgcaccc tacctcagtg    360

catgccctga gacctgcaga catccaagtt gtggctgctc tgggggattc tctgaccgct    420

ggcaatggaa ttggctccaa accagacgac ctccccgatg tcaccacaca gtatcgggga    480

ctgtcataca gagaaagtaa accagggttc ttatcagact cctgggtcag caaatccaac    540

aggaaatgca ccagaaaagc accaaatccc tgaatcttca cctccccgct tgcatgtata    600

cgtgtacacg tggtgttcct acgtctctgt ttactgtctt tatgtgttta ttcatgttgt    660

cttgtagtca cacagctgcc tttacatata tgtacacatc tgcacagaaa acctctgaaa    720

cccatcgcac acttcgagag gccataacca agacacaatc acaatcagcc atgtcttgaa    780

agattagcaa ttcgacaaga ggaaagggtg agaaagggca tcccgaacac ggaagtggag    840

aagctcaggg tgtgtcaggc gagcggttgc gtgtagatat tctcaagttt ctttctctcc    900

taataaagtt ctcattcctg taggcttc                                       928


<210>  7628
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  7628

Met Pro Lys Thr Ser Glu Gly Leu Pro Asp Asn Ser Phe Phe Ala Pro 
1               5                   10                  15      


Asp Cys Phe His Phe Ser Ser Lys Ser His Ser Arg Ala Ala Ser Ala 
            20                  25                  30          


Leu Trp Asn Asn Met Leu Glu Pro Val Gly Gln Lys Thr Thr Arg His 
        35                  40                  45              


Lys Phe Glu Asn Lys Ile Asn Ile Thr Cys Pro Asn Gln Val Gln Pro 
    50                  55                  60                  


Phe Leu Arg Thr Tyr Lys Asn Ser Met Gln Gly His Gly Thr Trp Leu 
65                  70                  75                  80  


Pro Cys Arg Asp Arg Ala Pro Ser Ala Leu His Pro Thr Ser Val His 
                85                  90                  95      


Ala Leu Arg Pro Ala Asp Ile Gln Val Val Ala Ala Leu Gly Asp Ser 
            100                 105                 110         


Leu Thr Ala Gly Asn Gly Ile Gly Ser Lys Pro Asp Asp Leu Pro Asp 
        115                 120                 125             


Val Thr Thr Gln Tyr Arg Gly Leu Ser Tyr Arg Glu Ser Lys Pro Gly 
    130                 135                 140                 


Phe Leu Ser Asp Ser Trp Val Ser Lys Ser Asn Arg Lys Cys Thr Arg 
145                 150                 155                 160 


Lys Ala Pro Asn Pro 
                165 


<210>  7629
<211>  2614
<212>  DNA
<213>  Homosapiens

<400>  7629
atggagctaa caagaaatgg aatggagaag cccagagctc tggctgaagg ttccagtctt     60

cccactggcc catctttgac aacagcaagt agtcaactgt tcatctcaga ttttgacatg    120

aatctgtatt ctgcagccaa ctttgttcac catctccgca atgccttgga cgtcctgcat    180

agagaggtgc ccagagtcct ggtcaacctc gtggacttcc tgaaccccac tatcatgcgg    240

caggtgttcc tgggaaaccc agacaagtgc ccagtgcagc aggccagcgt tttgtgtaac    300

tgcgttctga ccctgcggga gaactcccaa gagctagcca ggctggaggc cttcagccga    360

gcctaccgga gcagcatgcg cgagctggtg gggtcaggcc gctatgacac gcaggaggac    420

ttctctgtgg tgctgcagcc cttcttccag aacatccagc tccctgtcct ggcggatggg    480

ctcccagata cgtccttctt tgccccagac tgcatccacc caaatcagaa attccactcc    540

cagctggcca gagccctttg gaccaatatg cttgaaccac ttggaagcaa aacagagacc    600

ctggacctga gagcagagat gcccatcacc tgtcccactc agaatgagcc cttcctgaga    660

acccctcgga atagtaacta cacgtacccc atcaagccag ccattgagaa ctggggcagt    720

gacttcctgt gtacagagtg gaaggcttcc aatagtgttc caacctctgt ccaccagctc    780

cgaccagcag acatcaaagt ggtggccgcc ctgggtgact ctctgactac agcagtggga    840

gctcgaccaa acaactccag tgacctaccc acatcttgga ggggactctc ttggagcatt    900

ggaggggatg ggaacttgga gactcacacc acactgccca acattctgaa gaagttcaac    960

ccttacctcc ttggcttctc taccagcacc tgggagggga cagcaggact aaatgtggca   1020

gcggaagggg ccagagctag ggacatgcca gcccaggcct gggacctggt agagcgaatg   1080

aaaaacagcc ccgacatcaa cctggagaaa gactggaagc tggtcacact cttcattggg   1140

gtcaacgact tgtgtcatta ctgtgagaat ccggaggccc acttggccac ggaatatgtt   1200

cagcacatcc aacaggccct ggacatcctc tctgaggagc tcccaagggc tttcgtcaac   1260

gtggtggagg tcatggagct ggctagcctg taccagggcc aaggcgggaa atgtgccatg   1320

ctggcagctc agaacaactg cacttgcctc agacactcgc aaagctccct ggagaagcaa   1380

gaactgaaga aagtgaactg gaacctccag catggcatct ccagtttctc ctactggcac   1440

caatacacac agcgtgagga ctttgcggtt gtggtgcagc ctttcttcca aaacacactc   1500

accccactga acgagagagg ggacactgac ctcaccttct tctccgagga ctgttttcac   1560

ttctcagacc gcgggcatgc cgagatggcc atcgcactct ggaacaacat gctggaacca   1620

gtgggccgca agactacctc caacaacttc acccacagcc gagccaaact caagtgcccc   1680

tctcctgaga gcccttacct ctacaccctg cggaacagcc gattgctccc agaccaggct   1740

gaagaagccc ccgaggtgct ctactgggct gtcccagtgg cagcgggagt cggccttgtg   1800

gtgggcatca tcgggacagt ggtctggagg tgcaggagag gtggccggag ggaagatcct   1860

ccaatgagcc tgcgcactgt ggccctctag gcccgggggt gggtcctcac cctaaactcc   1920

ctatagccac tctcttcacc gccctctgcc ccagccactc ccggccacca ggacatgctt   1980

caatgcctgg tgccatagga agcccagggg acagtcacaa cttcttgggg cctgggcttc   2040

ttccaggcct atgctcctgg aatggataca tttaaataaa gtccaaagct attttattcc   2100

tgggtttgcc tgcgtgaagc actcaccttc catctcttgt gcagcccagg tgtgggagct   2160

gccacttttt gtggcctgcc tccagcaggg ctgcccaagc cacgaccaac cagagcccaa   2220

actgcctgcc accacgagca tatcctcaag tcaccaaacc cactatttca aaggcagaaa   2280

aaatgctggt caccaggtgg tggctggaat tttggagctg gctggttgcc attcagtcca   2340

atccaacaca tacctattaa gcaactgttt tgtatccagg acaatgcgaa gcactgaggt   2400

gcctcctagg ctgtgcatgt cgcagcctgg cagagaggtc aaactccttc aataaccaag   2460

aagccacgtg atgatgtgta actactaggg catcagtagg taaatgtgtc tgattgtttt   2520

aaagaataga aagggttctt cggggaaagt ttcttggggg agagcaacct tcacatgtca   2580

ttttgggaaa aggaataaaa aatgattggg acac                               2614


<210>  7630
<211>  629
<212>  PRT
<213>  Homosapiens

<400>  7630

Met Glu Leu Thr Arg Asn Gly Met Glu Lys Pro Arg Ala Leu Ala Glu 
1               5                   10                  15      


Gly Ser Ser Leu Pro Thr Gly Pro Ser Leu Thr Thr Ala Ser Ser Gln 
            20                  25                  30          


Leu Phe Ile Ser Asp Phe Asp Met Asn Leu Tyr Ser Ala Ala Asn Phe 
        35                  40                  45              


Val His His Leu Arg Asn Ala Leu Asp Val Leu His Arg Glu Val Pro 
    50                  55                  60                  


Arg Val Leu Val Asn Leu Val Asp Phe Leu Asn Pro Thr Ile Met Arg 
65                  70                  75                  80  


Gln Val Phe Leu Gly Asn Pro Asp Lys Cys Pro Val Gln Gln Ala Ser 
                85                  90                  95      


Val Leu Cys Asn Cys Val Leu Thr Leu Arg Glu Asn Ser Gln Glu Leu 
            100                 105                 110         


Ala Arg Leu Glu Ala Phe Ser Arg Ala Tyr Arg Ser Ser Met Arg Glu 
        115                 120                 125             


Leu Val Gly Ser Gly Arg Tyr Asp Thr Gln Glu Asp Phe Ser Val Val 
    130                 135                 140                 


Leu Gln Pro Phe Phe Gln Asn Ile Gln Leu Pro Val Leu Ala Asp Gly 
145                 150                 155                 160 


Leu Pro Asp Thr Ser Phe Phe Ala Pro Asp Cys Ile His Pro Asn Gln 
                165                 170                 175     


Lys Phe His Ser Gln Leu Ala Arg Ala Leu Trp Thr Asn Met Leu Glu 
            180                 185                 190         


Pro Leu Gly Ser Lys Thr Glu Thr Leu Asp Leu Arg Ala Glu Met Pro 
        195                 200                 205             


Ile Thr Cys Pro Thr Gln Asn Glu Pro Phe Leu Arg Thr Pro Arg Asn 
    210                 215                 220                 


Ser Asn Tyr Thr Tyr Pro Ile Lys Pro Ala Ile Glu Asn Trp Gly Ser 
225                 230                 235                 240 


Asp Phe Leu Cys Thr Glu Trp Lys Ala Ser Asn Ser Val Pro Thr Ser 
                245                 250                 255     


Val His Gln Leu Arg Pro Ala Asp Ile Lys Val Val Ala Ala Leu Gly 
            260                 265                 270         


Asp Ser Leu Thr Thr Ala Val Gly Ala Arg Pro Asn Asn Ser Ser Asp 
        275                 280                 285             


Leu Pro Thr Ser Trp Arg Gly Leu Ser Trp Ser Ile Gly Gly Asp Gly 
    290                 295                 300                 


Asn Leu Glu Thr His Thr Thr Leu Pro Asn Ile Leu Lys Lys Phe Asn 
305                 310                 315                 320 


Pro Tyr Leu Leu Gly Phe Ser Thr Ser Thr Trp Glu Gly Thr Ala Gly 
                325                 330                 335     


Leu Asn Val Ala Ala Glu Gly Ala Arg Ala Arg Asp Met Pro Ala Gln 
            340                 345                 350         


Ala Trp Asp Leu Val Glu Arg Met Lys Asn Ser Pro Asp Ile Asn Leu 
        355                 360                 365             


Glu Lys Asp Trp Lys Leu Val Thr Leu Phe Ile Gly Val Asn Asp Leu 
    370                 375                 380                 


Cys His Tyr Cys Glu Asn Pro Glu Ala His Leu Ala Thr Glu Tyr Val 
385                 390                 395                 400 


Gln His Ile Gln Gln Ala Leu Asp Ile Leu Ser Glu Glu Leu Pro Arg 
                405                 410                 415     


Ala Phe Val Asn Val Val Glu Val Met Glu Leu Ala Ser Leu Tyr Gln 
            420                 425                 430         


Gly Gln Gly Gly Lys Cys Ala Met Leu Ala Ala Gln Asn Asn Cys Thr 
        435                 440                 445             


Cys Leu Arg His Ser Gln Ser Ser Leu Glu Lys Gln Glu Leu Lys Lys 
    450                 455                 460                 


Val Asn Trp Asn Leu Gln His Gly Ile Ser Ser Phe Ser Tyr Trp His 
465                 470                 475                 480 


Gln Tyr Thr Gln Arg Glu Asp Phe Ala Val Val Val Gln Pro Phe Phe 
                485                 490                 495     


Gln Asn Thr Leu Thr Pro Leu Asn Glu Arg Gly Asp Thr Asp Leu Thr 
            500                 505                 510         


Phe Phe Ser Glu Asp Cys Phe His Phe Ser Asp Arg Gly His Ala Glu 
        515                 520                 525             


Met Ala Ile Ala Leu Trp Asn Asn Met Leu Glu Pro Val Gly Arg Lys 
    530                 535                 540                 


Thr Thr Ser Asn Asn Phe Thr His Ser Arg Ala Lys Leu Lys Cys Pro 
545                 550                 555                 560 


Ser Pro Glu Ser Pro Tyr Leu Tyr Thr Leu Arg Asn Ser Arg Leu Leu 
                565                 570                 575     


Pro Asp Gln Ala Glu Glu Ala Pro Glu Val Leu Tyr Trp Ala Val Pro 
            580                 585                 590         


Val Ala Ala Gly Val Gly Leu Val Val Gly Ile Ile Gly Thr Val Val 
        595                 600                 605             


Trp Arg Cys Arg Arg Gly Gly Arg Arg Glu Asp Pro Pro Met Ser Leu 
    610                 615                 620                 


Arg Thr Val Ala Leu 
625                 


<210>  7631
<211>  490
<212>  DNA
<213>  Homosapiens

<400>  7631
gtctctttct agaatctgta ttctgcagcc aactttgttc accatctccg caatgccttg     60

gacgtcctgc atagagaggt gcccagagtc ctggtcaacc tcgtggactt cctgaacccc    120

actatcatgc ggcaggtgtt cctgggaaac ccagacaagt gcccagtgca gcaggccagc    180

ttgaaccact tggaagcaaa acagagaccc tggacctgag agcagagatg cccatcacct    240

gtcccactca gaatgagccc ttcctgagaa cccctcggaa tagtaactac acgtacccca    300

tcaagccagc cattgagaac tggggcagtg acttcctgtg tacagagtgg aaggcttcca    360

atagtgttcc aacctctgtc caccagctcc gaccagcaga catcaaagtg gtggccgccc    420

tgggtgactc tctgactgtg agtagtgagc catgaaccag gatgggcagc tcagagtcca    480

gccaggccct                                                           490


<210>  7632
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  7632

Met Pro Ile Thr Cys Pro Thr Gln Asn Glu Pro Phe Leu Arg Thr Pro 
1               5                   10                  15      


Arg Asn Ser Asn Tyr Thr Tyr Pro Ile Lys Pro Ala Ile Glu Asn Trp 
            20                  25                  30          


Gly Ser Asp Phe Leu Cys Thr Glu Trp Lys Ala Ser Asn Ser Val Pro 
        35                  40                  45              


Thr Ser Val His Gln Leu Arg Pro Ala Asp Ile Lys Val Val Ala Ala 
    50                  55                  60                  


Leu Gly Asp Ser Leu Thr Val Ser Ser Glu Pro 
65                  70                  75  


<210>  7633
<211>  1672
<212>  DNA
<213>  Homosapiens

<400>  7633
ctttgttcac catctccgca atgccttgga cgtcctgcat agagaggtgc ccagagtcct     60

ggtcaacctc gtggacttcc tgaaccccac tatcatgcgg caggtgttcc tgggaaaccc    120

agacaagtgc ccagtgcagc aggccagctt gaaccacttg gaagcaaaac agagaccctg    180

gacctgagag cagagatgcc catcacctgt cccactcaga atgagccctt cctgagaacc    240

cctcggaata gtaactacac gtaccccatc aagccagcca ttgagaactg gggcagtgac    300

ttcctgtgta cagagtggaa ggcttccaat agtgttccaa cctctgtcca ccagctccga    360

ccagcagaca tcaaagtggt ggccgccctg ggtgactctc tgactacagc agtgggagct    420

cgaccaaaca actccagtga cctacccaca tcttggaggg gactctcttg gagcattgga    480

ggggatggga acttggagac tcacaccaca ctgcccaaca ttctgaagaa gttcaaccct    540

tacctccttg gcttctctac cagcacctgg gaggggacag caggactaaa tgtggcagcg    600

gaaggggcca gagctaggga catgccagcc caggcctggg acctggtaga gcgaatgaaa    660

aacagccccg acatcaacct ggagaaagac tggaagctgg tcacactctt cattggggtc    720

aacgacttgt gtcattactg tgagaatccg gaggcccact tggccacgga atatgttcag    780

cacatccaac aggccctgga catcctctct gaggagctcc caagggcttt cgtcaacgtg    840

gtggaggtca tggagctggc tagcctgtac cagggccaag gcgggaaatg tgccatgctg    900

gcagctcaga acaactgcac ttgcctcaga cactcgcaaa gctccctgga gaagcaagaa    960

ctgaagaaag tgaactggaa cctccagcat ggcatctcca gtttctccta ctggcaccaa   1020

tacacacagc gtgaggactt tgcggttgtg gtgcagcctt tcttccaaaa cacactcacc   1080

ccactgaacg agagagggga cactgacctc accttcttct ccgaggactg ttttcacttc   1140

tcagaccgcg ggcatgccga gatggccatc gcactctgga acaacatgct ggaaccagtg   1200

ggccgcaaga ctacctccaa caacttcacc cacagccgag ccaaactcaa gtgcccctct   1260

cctgagagcc cttacctcta caccctgcgg aacagccgat tgctcccaga ccaggctgaa   1320

gaagcccccg aggtgctcta ctgggctgtc ccagtggcag cgggagtcgg ccttgtggtg   1380

ggcatcatcg ggacagtggt ctggaggtgc aggagaggtg gccggaggga agatcctcca   1440

atgagcctgc gcactgtggc cctctaggcc cgggggtggg tcctcaccct aaactcccta   1500

tagccactct cttcaccgcc ctctgcccca gccactcccg gccaccagga catgcttcaa   1560

tgcctggtgc cataggaagc ccaggggaca gtcacaactt cttggggcct gggcttcttc   1620

caggcctatg ctcctggaat ggatacattt aaataaagtc caaagctatt tt           1672


<210>  7634
<211>  423
<212>  PRT
<213>  Homosapiens

<400>  7634

Met Pro Ile Thr Cys Pro Thr Gln Asn Glu Pro Phe Leu Arg Thr Pro 
1               5                   10                  15      


Arg Asn Ser Asn Tyr Thr Tyr Pro Ile Lys Pro Ala Ile Glu Asn Trp 
            20                  25                  30          


Gly Ser Asp Phe Leu Cys Thr Glu Trp Lys Ala Ser Asn Ser Val Pro 
        35                  40                  45              


Thr Ser Val His Gln Leu Arg Pro Ala Asp Ile Lys Val Val Ala Ala 
    50                  55                  60                  


Leu Gly Asp Ser Leu Thr Thr Ala Val Gly Ala Arg Pro Asn Asn Ser 
65                  70                  75                  80  


Ser Asp Leu Pro Thr Ser Trp Arg Gly Leu Ser Trp Ser Ile Gly Gly 
                85                  90                  95      


Asp Gly Asn Leu Glu Thr His Thr Thr Leu Pro Asn Ile Leu Lys Lys 
            100                 105                 110         


Phe Asn Pro Tyr Leu Leu Gly Phe Ser Thr Ser Thr Trp Glu Gly Thr 
        115                 120                 125             


Ala Gly Leu Asn Val Ala Ala Glu Gly Ala Arg Ala Arg Asp Met Pro 
    130                 135                 140                 


Ala Gln Ala Trp Asp Leu Val Glu Arg Met Lys Asn Ser Pro Asp Ile 
145                 150                 155                 160 


Asn Leu Glu Lys Asp Trp Lys Leu Val Thr Leu Phe Ile Gly Val Asn 
                165                 170                 175     


Asp Leu Cys His Tyr Cys Glu Asn Pro Glu Ala His Leu Ala Thr Glu 
            180                 185                 190         


Tyr Val Gln His Ile Gln Gln Ala Leu Asp Ile Leu Ser Glu Glu Leu 
        195                 200                 205             


Pro Arg Ala Phe Val Asn Val Val Glu Val Met Glu Leu Ala Ser Leu 
    210                 215                 220                 


Tyr Gln Gly Gln Gly Gly Lys Cys Ala Met Leu Ala Ala Gln Asn Asn 
225                 230                 235                 240 


Cys Thr Cys Leu Arg His Ser Gln Ser Ser Leu Glu Lys Gln Glu Leu 
                245                 250                 255     


Lys Lys Val Asn Trp Asn Leu Gln His Gly Ile Ser Ser Phe Ser Tyr 
            260                 265                 270         


Trp His Gln Tyr Thr Gln Arg Glu Asp Phe Ala Val Val Val Gln Pro 
        275                 280                 285             


Phe Phe Gln Asn Thr Leu Thr Pro Leu Asn Glu Arg Gly Asp Thr Asp 
    290                 295                 300                 


Leu Thr Phe Phe Ser Glu Asp Cys Phe His Phe Ser Asp Arg Gly His 
305                 310                 315                 320 


Ala Glu Met Ala Ile Ala Leu Trp Asn Asn Met Leu Glu Pro Val Gly 
                325                 330                 335     


Arg Lys Thr Thr Ser Asn Asn Phe Thr His Ser Arg Ala Lys Leu Lys 
            340                 345                 350         


Cys Pro Ser Pro Glu Ser Pro Tyr Leu Tyr Thr Leu Arg Asn Ser Arg 
        355                 360                 365             


Leu Leu Pro Asp Gln Ala Glu Glu Ala Pro Glu Val Leu Tyr Trp Ala 
    370                 375                 380                 


Val Pro Val Ala Ala Gly Val Gly Leu Val Val Gly Ile Ile Gly Thr 
385                 390                 395                 400 


Val Val Trp Arg Cys Arg Arg Gly Gly Arg Arg Glu Asp Pro Pro Met 
                405                 410                 415     


Ser Leu Arg Thr Val Ala Leu 
            420             


<210>  7635
<211>  574
<212>  DNA
<213>  Homosapiens

<400>  7635
agatttttcc taccaggaag agcatgtgct gaccaacaga catgaatttc agcctggtag     60

ttacaacatt cacagacaaa ctgcggcctg gaccagctgg tgaaacataa ttctgaatcc    120

tgcccacagc cttcggtggt tttggatgaa aggccagcgc cttgggagcc ctgcgtttga    180

tttcaagttt taaggccggc actggtggag caatgaatgg tgaaagctct ccccttaaag    240

gagcacagtt gcctttaggt gactgctaac tcaggctttt gctgaggaca gtgtttactt    300

tgtgagctta atgacagggc tggctttctg ggagtgttgc aatgaaacag actcagacac    360

aggccatcat gggcctcctc cctagcaagg ccgccacggc tggcatctca agagcagtcc    420

gttgaacttg ggatttgggt gtgagacaca gtttcatcag aagaatttaa accaaagtct    480

acatttgccc tctagataaa tgtgtgtgtt cagcagcaac cacaactcct tgcctcattc    540

tcttggttga ttatgtgact gtgagaagaa aagc                                574


<210>  7636
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  7636

Leu Gln His Ser Gln Thr Asn Cys Gly Leu Asp Gln Leu Val Lys His 
1               5                   10                  15      


Asn Ser Glu Ser Cys Pro Gln Pro Ser Val Val Leu Asp Glu Arg Pro 
            20                  25                  30          


Ala Pro Trp Glu Pro Cys Val 
        35                  


<210>  7637
<211>  663
<212>  DNA
<213>  Homosapiens

<400>  7637
atcagtaact caggctgttt cccacactac aggccagcac tgtgggctct cagtttattg     60

ggaaatggaa ataagaggga aggacaaaag tccactggga agcagactgg acagaaagga    120

actctgagca gctaaactct gactaatccc agggtatacc tgcgttttct cttcaccaga    180

caaactgcgg cctggaccag ctggtgaaac ataattctga atcctgccca cagccttcgg    240

tggttttgga tgaaaggcca gcgccttggg agccctgcgt ttgatttcaa gttttaaggc    300

cggcactggt ggagcaatga atggtgaaag ctctcccctt aaaggagcac agttgccttt    360

aggtgactgc taactcaggc ttttgctgag gacagtgttt actttgtgag cttaatgaca    420

gggctggctt tctgggagtg ttgcaatgaa acagactcag acacaggcca tcatgggcct    480

cctccctagc aaggccgcca cggctggcat ctcaagagca gtccgttgaa cttgggattt    540

gggtgtgaga cacagtttca tcagaagaat ttaaaccaaa gtctacattt gccctctaga    600

taaatgtgtg tgttcagcag caaccacaac tccttgcctc attctcttgg ttgattatgt    660

gac                                                                  663


<210>  7638
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  7638

Ser Gln Gly Ile Pro Ala Phe Ser Leu His Gln Thr Asn Cys Gly Leu 
1               5                   10                  15      


Asp Gln Leu Val Lys His Asn Ser Glu Ser Cys Pro Gln Pro Ser Val 
            20                  25                  30          


Val Leu Asp Glu Arg Pro Ala Pro Trp Glu Pro Cys Val 
        35                  40                  45  


<210>  7639
<211>  759
<212>  DNA
<213>  Homosapiens

<400>  7639
gctgtttccc acactacagg ccagcactgt gggctctcag tttattggga aatggaaata     60

agagggaagg acaaaagtcc actgggaagc agactggaca gaaaggaact ctgagcagct    120

aaactctgac taatcccagg gtatacctgc gttttctctt caccagattt ttcctaccag    180

gaagagcatg tgctgaccaa cagacatgaa tttcagcctg gtagttacaa cattcacagt    240

atacccacat cactaagctg ggaggcacat tttgagaccc agaatcctga cacctccatg    300

ccttcaaaag gacaaactgc ggcctggacc agctggtgaa acataattct gaatcctgcc    360

cacagccttc ggtggttttg gatgaaaggc cagcgccttg ggagccctgc gtttgatttc    420

aagttttaag gccggcactg gtggagcaat gaatggtgaa agctctcccc ttaaaggagc    480

acagttgcct ttaggtgact gctaactcag gcttttgctg aggacagtgt ttactttgtg    540

agcttaatga cagggctggc tttctgggag tgttgcaatg aaacagactc agacacaggc    600

catcatgggc ctcctcccta gcaaggccgc cacggctggc atctcaagag cagtccgttg    660

aacttgggat ttgggtgtga gacacagttt catcagaaga atttaaacca aagtctacat    720

ttgccctcta gataaatgtg tgtgttcagc agcaaccac                           759


<210>  7640
<211>  41
<212>  PRT
<213>  Homosapiens

<400>  7640

His Leu His Ala Phe Lys Arg Thr Asn Cys Gly Leu Asp Gln Leu Val 
1               5                   10                  15      


Lys His Asn Ser Glu Ser Cys Pro Gln Pro Ser Val Val Leu Asp Glu 
            20                  25                  30          


Arg Pro Ala Pro Trp Glu Pro Cys Val 
        35                  40      


<210>  7641
<211>  723
<212>  DNA
<213>  Homosapiens

<400>  7641
gggaagcaga ctggacagaa aggaactctg agcagctaaa ctctgactaa tcccagggta     60

tacctgcgtt ttctcttcac cagatttttc ctaccaggaa gagcatgtgc tgaccaacag    120

acatgaattt cagcctggta gttacaacat tcacaggagt ttcactcgtt gcccaggctg    180

gagtgcaacg gcgcgatctc agctcactgc aacctccgcc tccccagttc aagcgattct    240

cctgcctcag cctcctgagt cactggaatt acgggcgcct gacaccacgc ccagctaatt    300

ttttgtattt ttagtagaca tggggtttca ctatgttggc caggctggtc tcgaactcct    360

gacctcatga tcctcctgcc tcagcctccc aaagcactgg gattacaggt gtgagccact    420

gtgcctggtc cattaaaaac atttgtaaag ctatggtgtt gataaagtat tatgaaagac    480

tgcaaaaaaa gatggctaat ttttagttat tattgcacat gtttagagga gctaatgaca    540

ttttctatga ttaataaaag acattattta tgtttttatt tatgtattcc acaacattta    600

ttttattttc tccatttcag gaaaaccact atgttgttac aataaagatt ttcatgtaat    660

ttgtgttcaa ttgatagtaa taatgtaaca agttaaaaat gaaggtaatt gtgtttaaaa    720

ttt                                                                  723


<210>  7642
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  7642

Met Asn Phe Ser Leu Val Val Thr Thr Phe Thr Gly Val Ser Leu Val 
1               5                   10                  15      


Ala Gln Ala Gly Val Gln Arg Arg Asp Leu Ser Ser Leu Gln Pro Pro 
            20                  25                  30          


Pro Pro Gln Phe Lys Arg Phe Ser Cys Leu Ser Leu Leu Ser His Trp 
        35                  40                  45              


Asn Tyr Gly Arg Leu Thr Pro Arg Pro Ala Asn Phe Leu Tyr Phe 
    50                  55                  60              


<210>  7643
<211>  4790
<212>  DNA
<213>  Homosapiens

<400>  7643
ggagagctgc gtgacgcggc ggcgcgcaag ggacgtgcgg agtgagtggc gctgcgggtg     60

gggccgtcgg cggcgctggt gagagaacgc cgagccgtcg ccgcagcctc cgccgccgag    120

aagcccttgt tcccgctgct gggaaggaga gtctgtgccg acaagatggc ggacggggag    180

ctgaacgtgg acagcctcat cacccggctg ctggaggtac gaggatgtcg tccaggaaag    240

attgtgcaga tgactgaagc agaagttcga ggcttatgta tcaagtctcg ggagatcttt    300

ctcagccagc ctattctttt ggaattggaa gcaccgctga aaatttgtgg agatattcat    360

ggacaatata cagatttact gagattattt gaatatggag gtttcccacc agaagccaac    420

tatcttttct taggagatta tgtggacaga ggaaagcagt ctttggaaac catttgtttg    480

ctattggctt ataaaatcaa atatccagag aacttctttc tcttaagagg aaaccatgag    540

tgtgctagca tcaatcgcat ttatggattc tatgatgaat gcaaacgaag atttaatatt    600

aaattgtgga agaccttcac tgattgtttt aactgtctgc ctatagcagc cattgtggat    660

gagaagatct tctgttgtca tggaggattg tcaccagacc tgcaatctat ggagcagatt    720

cggagaatta tgagacctac tgatgtccct gatacaggtt tgctctgtga tttgctatgg    780

tctgatccag ataaggatgt gcaaggctgg ggagaaaatg atcgtggtgt ttcctttact    840

tttggagctg atgtagtcag taaatttctg aatcgtcatg atttagattt gatttgtcga    900

gctcatcagg tggtggaaga tggatatgaa ttttttgcta aacgacagtt ggtaacctta    960

ttttcagccc caaattactg tggcgagttt gataatgctg gtggaatgat gagtgtggat   1020

gaaactttga tgtgttcatt tcagatattg aaaccatctg aaaagaaagc taaataccag   1080

tatggtggac tgaattctgg acgtcctgtc actccacctc gaacagctaa tccgccgaag   1140

aaaaggtgaa gaaaggaatt ctgtaaagaa accatcagat ttgttaagga catacttcat   1200

aatatataag tgtgcactgt aaaaccatcc agccatttga caccctttat gatgtcacac   1260

ctttaactta aggagacggg taaaggatct taaatttttt tctaatagaa agatgtgcta   1320

cactgtattg taataagtat actctgttat agtcaacaaa gttaaatcca aattcaaaat   1380

tatccattaa agttacatct tcatgtatca caatttttaa agttgaaaag catcccagtt   1440

aaactagatg tgatagttaa accagatgaa agcatgatga tccatctgtg taatgtggtt   1500

ttagtgttgc ttggttgttt aattattttg agcttgtttt gtttttgttt gttttcacta   1560

gaataatggc aaatacttct aatttttttc cctaaacatt tttaaaagtg aaatatggga   1620

agagctttac agacattcac caactattat tttcccttgt ttatctactt agatatctgt   1680

ttaatcttac taagaaaact ttcgcctcat tacattaaaa aggaatttta gagattgatt   1740

gttttaaaaa aaaatacgca cattgtccaa tccagtgatt ttaatcatac agtttgactg   1800

ggcaaacttt acagctgata gtgaatattt tgctttatac aggaattgac actgatttgg   1860

atttgtgcac tctaattttt aacttattga tgctctattg tgcagtagca tttcatttaa   1920

gataaggctc atatagtatt acccaactag ttggtaatgt gattatgtgg taccttggct   1980

ttaggttttc attcgcacgg aacacctttt ggcatgctta acttcctggt aacaccttca   2040

cctgcattgg ttttcttttt cttttttctt tctttttttt tttttttttt tttttgagtt   2100

gttgtttgtt tttagatcca cagtacatga gaatcctttt ttgacaagcc ttggaaagct   2160

gacactgtct ctttttcctc cctctatacg aaggatgtat ttaaatgaat gctggtcagt   2220

gggacatttt gtcaactatg ggtattgggt gcttaactgt ctaatattgc catgtgaatg   2280

ttgtatacga ttgtaaggct tatgtcacta aagattttta ttctgatttt ttcataatca   2340

aaggtcatat gatactgtat agacaagctt tgtagtgaag tatagtagca ataatttctg   2400

tacctgatca agtttattgc agcctttctt ttcctatttc ttttttttaa gggttagtat   2460

taacaaatgg caatgagtag aaaagttaac atgaagattt tagaaggaga gaacttacag   2520

gacacagatt tgtgattctt tgactgtgac actattggat gtgattctaa aagcttttat   2580

tgagcattgt caaatttgta agcttcatag ggatggacat catatctata atgcccttct   2640

atatgtgcta ccatagatgt gacatttttg accttaatat cgtctttgaa aatgttaaat   2700

tgagaaacct gttaacttac attttatgaa ttggcacatt gtattactta ctgcaagaga   2760

tatttcattt tcagcacagt gcaaaagttc tttaaaatgc atatgtcttt ttttctaatt   2820

ccgttttgtt ttaaagcaca ttttaaatgt agttttctca tttagtaaaa gttgtctaat   2880

tgatatgaag cctgactgat tttttttttc cttacagtga gacatttaag cacacatttt   2940

attcacatag atactatgtc cttgacatat tgaaatgatt cttttctgaa agtattcatg   3000

atctgcatat gatgtattag gttaggtcac aaaggtttta tctgaggtga tttaaataac   3060

ttcctgattg gagtgtgtaa gctgagcgat ttctaataaa attttagttg tacactttta   3120

gtagtcatag tgaagcaggt ctagaaaata agcctttggc agggaaaaag ggcaatgttg   3180

attaatctca gtattaaacc acattaatct gtatcccatt gtctggcttt tgtaaattca   3240

tccaggtcaa gactaagtat gttggttaat aggaatcctt tttttttttt ttaaagacta   3300

aatgtgaaaa aataatcact acttaagcta attaatattg gtcattaaat ttaaaggatg   3360

gaaatttatc atgtttaaaa attattcaag cactcttaaa accacttaaa cagcctccag   3420

tcataaaaat gtgttcttta caaatatttg cttggcaaca cgacttgaaa taaataaaac   3480

tttgtttctt aggagaaaat gattctgtaa ttccagtgtc actaatttat attgttcttt   3540

cctctgattt ttttcaggtt agtgattttt ttgtatacaa tttaatccaa atgttatgac   3600

attcagaaat catgaaacac agtagatatc tgttataatg tggtgtatca catggattat   3660

aaagcaaagt tatggtcgat ttctattctt gaaagaatca actacagtga atcctttgca   3720

tttgaagcct taacatgcat tgctttaatt ttgcccaggg acaaatttta ataatcagca   3780

agactggttt gtgcaaagcg ttgagtcatc aggtatttag agcctagcca gctacccagt   3840

atccatgctg ccatatccct tcattgtaaa aagtacctaa acattcgtga aatgattttt   3900

tttagctgaa aaatgctggc aagaagaatt ttaaagctta aaataggtgg taaatttgaa   3960

gtatgagtgt gttcacgaga aacataggct tttcaaaaaa atttttattc aaggcaaagc   4020

aaggaacatc ttgagatatg tctcaagaat ataaagatgt attattttaa gccaaggagc   4080

tgaaatatat ctcagtttat aaattcaggt atattctttt tgtctccatg gcaaccataa   4140

cttttgaacc aaaaaaaatt gtttttacat ctttatgctg aaaatgtgtt tagattagga   4200

atatggtcgg gctgaatttg ctgttgctcc ctaaccaaat ccacctcttg ttttccttgt   4260

gagtccatgg ctaaatcaaa gctgcccctg agaagagact taatccaagc ctgattgtac   4320

tagtggcatc acttagaagt aggctttccc tcttcctagt agatctcaat gttttataat   4380

tccttaaaac agctgaaaat tgggacaaca tactttacgc aatgaacagt agttaaatag   4440

gaaataaact agttccatat aagtatacac ctagagtttt aattaccttt ataatgtttc   4500

ttaaaagtga aacttagata caattgtgat tggatactta gatactaagt gaaacttagt   4560

gtaacaattt tgatctgtta aattggattt tacatgtaca tttgaatgcc agaatttcta   4620

aataaatccc ctggttagga aattttaaaa gtcaaagctt gttttcttca accactacct   4680

tctacattgg ttgacttaga ccgtaagctt tttaagtttc tcattgtaat ttaccttctc   4740

atgcagattg ctgatgtttt attaaacctt atttttacaa aaatgaccat              4790


<210>  7644
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  7644

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                165                 170                 175     


Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
            180                 185                 190         


Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
        195                 200                 205             


Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
    210                 215                 220                 


Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
    290                 295                 300                 


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
305                 310                 315                 320 


Ala Asn Pro Pro Lys Lys Arg 
                325         


<210>  7645
<211>  4291
<212>  DNA
<213>  Homosapiens

<400>  7645
gctgcgtgac gcggcggcgc gcaagggacg tgcggagtga gtggcgctgc gggtggggcc     60

gtcggcggcg ctggtgagct ttgcggagct gggcggtgcc gaggaggagg aggtggcggc    120

ctgggtctga cgcggccctg ttcgaggggg cctctcttgt ttatttattt attttccgtg    180

ggtgcctccg agtgtgcgcg cgctctcgct acccggcggg gagggggtgg ggggagggcc    240

cgggaaaagg gggagttgga gccggggtcg aaacgccgcg tgacttgtag gtgagagaac    300

gccgagccgt cgccgcagcc tccgccgccg agaagccctt gttcccgctg ctgggaagga    360

gagtctgtgc cgacaagatg gcggacgggg agctgaacgt ggacagcctc atcacccggc    420

ttgtctgcct atagcagcca ttgtggatga gaagatcttc tgttgtcatg gaggattgtc    480

accagacctg caatctatgg agcagattcg gagaattatg agacctactg atgtccctga    540

tacagatatt gaaaccatct gaaaagaaag ctaaatacca gtatggtgga ctgaattctg    600

gacgtcctgt cactccacct cgaacagcta atccgccgaa gaaaaggtga agaaaggaat    660

tctgtaaaga aaccatcaga tttgttaagg acatacttca taatatataa gtgtgcactg    720

taaaaccatc cagccatttg acacccttta tgatgtcaca cctttaactt aaggagacgg    780

gtaaaggatc ttaaattttt ttctaataga aagatgtgct acactgtatt gtaataagta    840

tactctgtta tagtcaacaa agttaaatcc aaattcaaaa ttatccatta aagttacatc    900

ttcatgtatc acaattttta aagttgaaaa gcatcccagt taaactagat gtgatagtta    960

aaccagatga aagcatgatg atccatctgt gtaatgtggt tttagtgttg cttggttgtt   1020

taattatttt gagcttgttt tgtttttgtt tgttttcact agaataatgg caaatacttc   1080

taattttttt ccctaaacat ttttaaaagt gaaatatggg aagagcttta cagacattca   1140

ccaactatta ttttcccttg tttatctact tagatatctg tttaatctta ctaagaaaac   1200

tttcgcctca ttacattaaa aaggaatttt agagattgat tgttttaaaa aaaaatacgc   1260

acattgtcca atccagtgat tttaatcata cagtttgact gggcaaactt tacagctgat   1320

agtgaatatt ttgctttata caggaattga cactgatttg gatttgtgca ctctaatttt   1380

taacttattg atgctctatt gtgcagtagc atttcattta agataaggct catatagtat   1440

tacccaacta gttggtaatg tgattatgtg gtaccttggc tttaggtttt cattcgcacg   1500

gaacaccttt tggcatgctt aacttcctgg taacaccttc acctgcattg gttttctttt   1560

tcttttttct ttcttttttt tttttttttt ttttttgagt tgttgtttgt ttttagatcc   1620

acagtacatg agaatccttt tttgacaagc cttggaaagc tgacactgtc tctttttcct   1680

ccctctatac gaaggatgta tttaaatgaa tgctggtcag tgggacattt tgtcaactat   1740

gggtattggg tgcttaactg tctaatattg ccatgtgaat gttgtatacg attgtaaggc   1800

ttatgtcact aaagattttt attctgattt tttcataatc aaaggtcata tgatactgta   1860

tagacaagct ttgtagtgaa gtatagtagc aataatttct gtacctgatc aagtttattg   1920

cagcctttct tttcctattt ctttttttta agggttagta ttaacaaatg gcaatgagta   1980

gaaaagttaa catgaagatt ttagaaggag agaacttaca ggacacagat ttgtgattct   2040

ttgactgtga cactattgga tgtgattcta aaagctttta ttgagcattg tcaaatttgt   2100

aagcttcata gggatggaca tcatatctat aatgcccttc tatatgtgct accatagatg   2160

tgacattttt gaccttaata tcgtctttga aaatgttaaa ttgagaaacc tgttaactta   2220

cattttatga attggcacat tgtattactt actgcaagag atatttcatt ttcagcacag   2280

tgcaaaagtt ctttaaaatg catatgtctt tttttctaat tccgttttgt tttaaagcac   2340

attttaaatg tagttttctc atttagtaaa agttgtctaa ttgatatgaa gcctgactga   2400

tttttttttt ccttacagtg agacatttaa gcacacattt tattcacata gatactatgt   2460

ccttgacata ttgaaatgat tcttttctga aagtattcat gatctgcata tgatgtatta   2520

ggttaggtca caaaggtttt atctgaggtg atttaaataa cttcctgatt ggagtgtgta   2580

agctgagcga tttctaataa aattttagtt gtacactttt agtagtcata gtgaagcagg   2640

tctagaaaat aagcctttgg cagggaaaaa gggcaatgtt gattaatctc agtattaaac   2700

cacattaatc tgtatcccat tgtctggctt ttgtaaattc atccaggtca agactaagta   2760

tgttggttaa taggaatcct tttttttttt tttaaagact aaatgtgaaa aaataatcac   2820

tacttaagct aattaatatt ggtcattaaa tttaaaggat ggaaatttat catgtttaaa   2880

aattattcaa gcactcttaa aaccacttaa acagcctcca gtcataaaaa tgtgttcttt   2940

acaaatattt gcttggcaac acgacttgaa ataaataaaa ctttgtttct taggagaaaa   3000

tgattctgta attccagtgt cactaattta tattgttctt tcctctgatt tttttcaggt   3060

tagtgatttt tttgtataca atttaatcca aatgttatga cattcagaaa tcatgaaaca   3120

cagtagatat ctgttataat gtggtgtatc acatggatta taaagcaaag ttatggtcga   3180

tttctattct tgaaagaatc aactacagtg aatcctttgc atttgaagcc ttaacatgca   3240

ttgctttaat tttgcccagg gacaaatttt aataatcagc aagactggtt tgtgcaaagc   3300

gttgagtcat caggtattta gagcctagcc agctacccag tatccatgct gccatatccc   3360

ttcattgtaa aaagtaccta aacattcgtg aaatgatttt ttttagctga aaaatgctgg   3420

caagaagaat tttaaagctt aaaataggtg gtaaatttga agtatgagtg tgttcacgag   3480

aaacataggc ttttcaaaaa aatttttatt caaggcaaag caaggaacat cttgagatat   3540

gtctcaagaa tataaagatg tattatttta agccaaggag ctgaaatata tctcagttta   3600

taaattcagg tatattcttt ttgtctccat ggcaaccata acttttgaac caaaaaaaat   3660

tgtttttaca tctttatgct gaaaatgtgt ttagattagg aatatggtcg ggctgaattt   3720

gctgttgctc cctaaccaaa tccacctctt gttttccttg tgagtccatg gctaaatcaa   3780

agctgcccct gagaagagac ttaatccaag cctgattgta ctagtggcat cacttagaag   3840

taggctttcc ctcttcctag tagatctcaa tgttttataa ttccttaaaa cagctgaaaa   3900

ttgggacaac atactttacg caatgaacag tagttaaata ggaaataaac tagttccata   3960

taagtataca cctagagttt taattacctt tataatgttt cttaaaagtg aaacttagat   4020

acaattgtga ttggatactt agatactaag tgaaacttag tgtaacaatt ttgatctgtt   4080

aaattggatt ttacatgtac atttgaatgc cagaatttct aaataaatcc cctggttagg   4140

aaattttaaa agtcaaagct tgttttcttc aaccactacc ttctacattg gttgacttag   4200

accgtaagct ttttaagttt ctcattgtaa tttaccttct catgcagatt gctgatgttt   4260

tattaaacct tatttttaca aaaatgacca t                                  4291


<210>  7646
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  7646

Met Ser Leu Ile Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
1               5                   10                  15      


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
            20                  25                  30          


Ala Asn Pro Pro Lys Lys Arg 
        35                  


<210>  7647
<211>  4990
<212>  DNA
<213>  Homosapiens

<400>  7647
ggcggcgcgc aagggacgtg cggagtgagt ggcgctgcgg gtggggccgt cggcggcgct     60

ggtgagcttt gcggagctgg gcggtgccga ggaggaggag gtggcggcct gggtctgacg    120

cggccctgtt cgagggggcc tctcttgttt atttatttat tttccgtggg tgcctccgag    180

tgtgcgcgcg ctctcgctac ccggcgggga gggggtgggg ggagggcccg ggaaaagggg    240

gagttggagc cggggtcgaa acgccgcgtg acttgtaggt gagagaacgc cgagccgtcg    300

ccgcagcctc cgccgccgag aagcccttgt tcccgctgct gggaaggaga gtctgtgccg    360

acaagatggc ggacggggag ctgaacgtgg acagcctcat cacccggctg ctggaggtac    420

gaggatgtcg tccaggaaag attgtgcaga tgactgaagc agaagttcga ggcttatgta    480

tcaagtctcg ggagatcttt ctcagccagc ctattctttt ggaattggaa gcaccgctga    540

aaatttgtgg agatattcat ggacaatata cagatttact gagattattt gaatatggag    600

gtttcccacc agaagccaac tatcttttct taggagatta tgtggacaga ggaaagcagt    660

ctttggaaac catttgtttg ctattggctt ataaaatcaa atatccagag aacttctttc    720

tcttaagagg aaaccatgag tgtgctagca tcaatcgcat ttatggattc tatgatgaat    780

gcaaacgaag atttaatatt aaattgtgga agaccttcac tgattgtttt aactgtctgc    840

ctatagcagc cattgtggat gagaagatct tctgttgtca tggaggattg tcaccagacc    900

tgcaatctat ggagcagatt cggagaatta tgagacctac tgatgtccct gatacaggtt    960

tgctctgtga tttgctatgg tctgatccag ataaggatgt gcaaggctgg ggagaaaatg   1020

atcgtggtgt ttcctttact tttggagctg atgtagtcag taaatttctg aatcgtcatg   1080

atttagattt gatttgtcga gctcatcagg tggtggaaga tggatatgaa ttttttgcta   1140

aacgacagtt ggtaacctta ttttcagccc caaattactg tggcgagttt gataatgctg   1200

gtggaatgat gagtgtggat gaaactttga tgtgttcatt tcagatattg aaaccatctg   1260

aaaagaaagc taaataccag tatggtggac tgaattctgg acgtcctgtc actccacctc   1320

gaacagctaa tccgccgaag aaaaggtgaa gaaaggaatt ctgtaaagaa accatcagat   1380

ttgttaagga catacttcat aatatataag tgtgcactgt aaaaccatcc agccatttga   1440

caccctttat gatgtcacac ctttaactta aggagacggg taaaggatct taaatttttt   1500

tctaatagaa agatgtgcta cactgtattg taataagtat actctgttat agtcaacaaa   1560

gttaaatcca aattcaaaat tatccattaa agttacatct tcatgtatca caatttttaa   1620

agttgaaaag catcccagtt aaactagatg tgatagttaa accagatgaa agcatgatga   1680

tccatctgtg taatgtggtt ttagtgttgc ttggttgttt aattattttg agcttgtttt   1740

gtttttgttt gttttcacta gaataatggc aaatacttct aatttttttc cctaaacatt   1800

tttaaaagtg aaatatggga agagctttac agacattcac caactattat tttcccttgt   1860

ttatctactt agatatctgt ttaatcttac taagaaaact ttcgcctcat tacattaaaa   1920

aggaatttta gagattgatt gttttaaaaa aaaatacgca cattgtccaa tccagtgatt   1980

ttaatcatac agtttgactg ggcaaacttt acagctgata gtgaatattt tgctttatac   2040

aggaattgac actgatttgg atttgtgcac tctaattttt aacttattga tgctctattg   2100

tgcagtagca tttcatttaa gataaggctc atatagtatt acccaactag ttggtaatgt   2160

gattatgtgg taccttggct ttaggttttc attcgcacgg aacacctttt ggcatgctta   2220

acttcctggt aacaccttca cctgcattgg ttttcttttt cttttttctt tctttttttt   2280

tttttttttt tttttgagtt gttgtttgtt tttagatcca cagtacatga gaatcctttt   2340

ttgacaagcc ttggaaagct gacactgtct ctttttcctc cctctatacg aaggatgtat   2400

ttaaatgaat gctggtcagt gggacatttt gtcaactatg ggtattgggt gcttaactgt   2460

ctaatattgc catgtgaatg ttgtatacga ttgtaaggct tatgtcacta aagattttta   2520

ttctgatttt ttcataatca aaggtcatat gatactgtat agacaagctt tgtagtgaag   2580

tatagtagca ataatttctg tacctgatca agtttattgc agcctttctt ttcctatttc   2640

ttttttttaa gggttagtat taacaaatgg caatgagtag aaaagttaac atgaagattt   2700

tagaaggaga gaacttacag gacacagatt tgtgattctt tgactgtgac actattggat   2760

gtgattctaa aagcttttat tgagcattgt caaatttgta agcttcatag ggatggacat   2820

catatctata atgcccttct atatgtgcta ccatagatgt gacatttttg accttaatat   2880

cgtctttgaa aatgttaaat tgagaaacct gttaacttac attttatgaa ttggcacatt   2940

gtattactta ctgcaagaga tatttcattt tcagcacagt gcaaaagttc tttaaaatgc   3000

atatgtcttt ttttctaatt ccgttttgtt ttaaagcaca ttttaaatgt agttttctca   3060

tttagtaaaa gttgtctaat tgatatgaag cctgactgat tttttttttc cttacagtga   3120

gacatttaag cacacatttt attcacatag atactatgtc cttgacatat tgaaatgatt   3180

cttttctgaa agtattcatg atctgcatat gatgtattag gttaggtcac aaaggtttta   3240

tctgaggtga tttaaataac ttcctgattg gagtgtgtaa gctgagcgat ttctaataaa   3300

attttagttg tacactttta gtagtcatag tgaagcaggt ctagaaaata agcctttggc   3360

agggaaaaag ggcaatgttg attaatctca gtattaaacc acattaatct gtatcccatt   3420

gtctggcttt tgtaaattca tccaggtcaa gactaagtat gttggttaat aggaatcctt   3480

tttttttttt ttaaagacta aatgtgaaaa aataatcact acttaagcta attaatattg   3540

gtcattaaat ttaaaggatg gaaatttatc atgtttaaaa attattcaag cactcttaaa   3600

accacttaaa cagcctccag tcataaaaat gtgttcttta caaatatttg cttggcaaca   3660

cgacttgaaa taaataaaac tttgtttctt aggagaaaat gattctgtaa ttccagtgtc   3720

actaatttat attgttcttt cctctgattt ttttcaggtt agtgattttt ttgtatacaa   3780

tttaatccaa atgttatgac attcagaaat catgaaacac agtagatatc tgttataatg   3840

tggtgtatca catggattat aaagcaaagt tatggtcgat ttctattctt gaaagaatca   3900

actacagtga atcctttgca tttgaagcct taacatgcat tgctttaatt ttgcccaggg   3960

acaaatttta ataatcagca agactggttt gtgcaaagcg ttgagtcatc aggtatttag   4020

agcctagcca gctacccagt atccatgctg ccatatccct tcattgtaaa aagtacctaa   4080

acattcgtga aatgattttt tttagctgaa aaatgctggc aagaagaatt ttaaagctta   4140

aaataggtgg taaatttgaa gtatgagtgt gttcacgaga aacataggct tttcaaaaaa   4200

atttttattc aaggcaaagc aaggaacatc ttgagatatg tctcaagaat ataaagatgt   4260

attattttaa gccaaggagc tgaaatatat ctcagtttat aaattcaggt atattctttt   4320

tgtctccatg gcaaccataa cttttgaacc aaaaaaaatt gtttttacat ctttatgctg   4380

aaaatgtgtt tagattagga atatggtcgg gctgaatttg ctgttgctcc ctaaccaaat   4440

ccacctcttg ttttccttgt gagtccatgg ctaaatcaaa gctgcccctg agaagagact   4500

taatccaagc ctgattgtac tagtggcatc acttagaagt aggctttccc tcttcctagt   4560

agatctcaat gttttataat tccttaaaac agctgaaaat tgggacaaca tactttacgc   4620

aatgaacagt agttaaatag gaaataaact agttccatat aagtatacac ctagagtttt   4680

aattaccttt ataatgtttc ttaaaagtga aacttagata caattgtgat tggatactta   4740

gatactaagt gaaacttagt gtaacaattt tgatctgtta aattggattt tacatgtaca   4800

tttgaatgcc agaatttcta aataaatccc ctggttagga aattttaaaa gtcaaagctt   4860

gttttcttca accactacct tctacattgg ttgacttaga ccgtaagctt tttaagtttc   4920

tcattgtaat ttaccttctc atgcagattg ctgatgtttt attaaacctt atttttacaa   4980

aaatgaccat                                                          4990


<210>  7648
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  7648

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                165                 170                 175     


Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
            180                 185                 190         


Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
        195                 200                 205             


Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
    210                 215                 220                 


Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
    290                 295                 300                 


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
305                 310                 315                 320 


Ala Asn Pro Pro Lys Lys Arg 
                325         


<210>  7649
<211>  792
<212>  DNA
<213>  Homosapiens

<400>  7649
gcgggtgggg ccgtcggcgg cgctggtgag ctttgcggag ctgggcggtg ccgaggagga     60

ggaggtggcg gcctgggtct gacgcggccc tgttcgaggg ggcctctctt gtttatttat    120

ttattttccg tgggtgcctc cgagtgtgcg cgcgctctcg ctacccggcg gggagggggt    180

ggggggaggg cccgggaaaa gggggagttg gagccggggt cgaaacgccg cgtgacttgt    240

aggtgagaga acgccgagcc gtcgccgcag cctccgccgc cgagaagccc ttgttcccgc    300

tgctgggaag gagagtctgt gccgacaaga tggcggacgg ggagctgaac gtggacagcc    360

tcatcacccg gctgctggag gtacgaggat gtcgtccagg aaagattgtg cagatgactg    420

aagcagaagt tcgaggctta tgtatcaagt ctcgggagat ctttctcagc cagcctattc    480

ttttggaatt ggaagcaccg ctgaaaattt gtggtatgta aatgggtaaa gttggaaaca    540

actcttttga atcatgtttt tcctcccatg tttaagatct agagaaaaca ttttttgaaa    600

tttttgtata aaacagatca gtaggcttta ctaaataaaa gtgtataaaa attgaaactt    660

ataaaaatga caagttacag acaagatgaa aatacttgct atatatcaac agataaaagg    720

agttctattt ataatatata aagagttctt ataaataaga gaaaggcgat acagtataaa    780

aataacatag ga                                                        792


<210>  7650
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  7650

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Met 
    50                  55                  60              


<210>  7651
<211>  985
<212>  DNA
<213>  Homosapiens

<400>  7651
gcgggtgggg ccgtcggcgg cgctggtgag ctttgcggag ctgggcggtg ccgaggagga     60

ggaggtggcg gcctgggtct gacgcggccc tgttcgaggg ggcctctctt gtttatttat    120

ttattttccg tgggtgcctc cgagtgtgcg cgcgctctcg ctacccggcg gggagggggt    180

ggggggaggg cccgggaaaa gggggagttg gagccggggt cgaaacgccg cgtgacttgt    240

aggtgagaga acgccgagcc gtcgccgcag cctccgccgc cgagaagccc ttgttcccgc    300

tgctgggaag gagagtctgt gccgacaaga tggcggacgg ggagctgaac gtggacagcc    360

tcatcacccg gctgctggag gtacgaggat gtcgtccagg aaagattgtg cagatgactg    420

aagcagaagt tcgaggctta tgtatcaagt ctcgggagat ctttctcagc cagcctattc    480

ttttggaatt ggaagcaccg ctgaaaattt gtggagatat tcatggacaa tatacagatt    540

tactgagatt atttgaatat ggaggtttcc caccagaagc caactatctt ttcttaggag    600

attatgtgga cagaggaaag cagtctttgg aaaccatttg tttgctattg gcttataaaa    660

tcaaatatcc agagaacttc tttctcttaa gaggaaacca tgagtgtgct agcatcaatc    720

gcatttatgg attctatgat gaatgcaaac gaagatttaa tattaaattg tggaagacct    780

tcactgattg ttttaactgt ctgcctatag cagccattgt ggatgagaag atcttctgtt    840

gtcatggagg tagactagta aatttgcctt acagattttt tttttcttct attattcgga    900

aaatacctat aataatcaag aggctgtggg aaaacaaagc agtgcttgta tgaaaactca    960

agtgattaaa actgttttaa acatg                                          985


<210>  7652
<211>  207
<212>  PRT
<213>  Homosapiens

<400>  7652

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Arg Leu 
                165                 170                 175     


Val Asn Leu Pro Tyr Arg Phe Phe Phe Ser Ser Ile Ile Arg Lys Ile 
            180                 185                 190         


Pro Ile Ile Ile Lys Arg Leu Trp Glu Asn Lys Ala Val Leu Val 
        195                 200                 205         


<210>  7653
<211>  3051
<212>  DNA
<213>  Homosapiens

<400>  7653
gcgggtgggg ccgtcggcgg cgctggtgag ctttgcggag ctgggcggtg ccgaggagga     60

ggaggtggcg gcctgggtct gacgcggccc tgttcgaggg ggcctctctt gtttatttat    120

ttattttccg tgggtgcctc cgagtgtgcg cgcgctctcg ctacccggcg gggagggggt    180

ggggggaggg cccgggaaaa gggggagttg gagccggggt cgaaacgccg cgtgacttgt    240

aggtgagaga acgccgagcc gtcgccgcag cctccgccgc cgagaagccc ttgttcccgc    300

tgctgggaag gagagtctgt gccgacaaga tggcggacgg ggagctgaac gtggacagcc    360

tcatcacccg gctgctggag gtacgaggat gtcgtccagg aaagattgtg cagatgactg    420

aagcagaagt tcgaggctta tgtatcaagt ctcgggagat ctttctcagc cagcctattc    480

ttttggaatt ggaagcaccg ctgaaaattt gtggagatat tcatggacaa tatacagatt    540

tactgagatt atttgaatat ggaggtttcc caccagaagc caactatctt ttcttaggag    600

attatgtgga cagaggaaag cagtctttgg aaaccatttg tttgctattg gcttataaaa    660

tcaaatatcc agagaacttc tttctcttaa gaggaaacca tgagtgtgct agcatcaatc    720

gcatttatgg attctatgat gaatgcaaac gaagatttaa tattaaattg tggaagacct    780

tcactgattg ttttaactgt ctgcctatag cagccattgt ggatgagaag atcttctgtt    840

gtcatggagg attgtcacca gacctgcaat ctatggagca gattcggaga attatgagac    900

ctactgatgt ccctgataca ggtttgctct gtgatttgct atggtctgat ccagataagg    960

atgtgcaagg ctggggagaa aatgatcgtg gtgtttcctt tacttttgga gctgatgtag   1020

tcagtaaatt tctgaatcgt catgatttag atttgatttg tcgagctcat caggtggtgg   1080

aagatggata tgaatttttt gctaaacgac agttggtaac cttattttca gccccaaatt   1140

actgtggcga gtttgataat gctggtggaa tgatgagtgt ggatgaaact ttgatgtgtt   1200

catttcagat attgaaacca tctgaaaaga aagctaaata ccagtatggt ggactgaatt   1260

ctggacgtcc tgtcactcca cctcgaacag ctaatccgcc gaagaaaagg tgaagaaagg   1320

aattctgtaa agaaaccatc agatttgtta aggacatact tcataatata taagtgtgca   1380

ctgtaaaacc atccagccat ttgacaccct ttatgatgtc acacctttaa cttaaggaga   1440

cgggtaaagg atcttaaatt tttttctaat agaaagatgt gctacactgt attgtaataa   1500

gtatactctg ttatagtcaa caaagttaaa tccaaattca aaattatcca ttaaagttac   1560

atcttcatgt atcacaattt ttaaagttga aaagcatccc agttaaacta gatgtgatag   1620

ttaaaccaga tgaaagcatg atgatccatc tgtgtaatgt ggttttagtg ttgcttggtt   1680

gtttaattat tttgagcttg ttttgttttt gtttgttttc actagaataa tggcaaatac   1740

ttctaatttt tttccctaaa catttttaaa agtgaaatat gggaagagct ttacagacat   1800

tcaccaacta ttattttccc ttgtttatct acttagatat ctgtttaatc ttactaagaa   1860

aactttcgcc tcattacatt aaaaaggaat tttagagatt gattgtttta aaaaaaaata   1920

cgcacattgt ccaatccagt gattttaatc atacagtttg actgggcaaa ctttacagct   1980

gatagtgaat attttgcttt atacaggaat tgacactgat ttggatttgt gcactctaat   2040

ttttaactta ttgatgctct attgtgcagt agcatttcat ttaagataag gctcatatag   2100

tattacccaa ctagttggta atgtgattat gtggtacctt ggctttaggt tttcattcgc   2160

acggaacacc ttttggcatg cttaacttcc tggtaacacc ttcacctgca ttggttttct   2220

ttttcttttt tctttctttt tttttttttt tttttttttg agttgttgtt tgtttttaga   2280

tccacagtac atgagaatcc ttttttgaca agccttggaa agctgacact gtctcttttt   2340

cctccctcta tacgaaggat gtatttaaat gaatgctggt cagtgggaca ttttgtcaac   2400

tatgggtatt gggtgcttaa ctgtctaata ttgccatgtg aatgttgtat acgattgtaa   2460

ggcttatgtc actaaagatt tttattctga ttttttcata atcaaaggtc atatgatact   2520

gtatagacaa gctttgtagt gaagtatagt agcaataatt tctgtacctg atcaagttta   2580

ttgcagcctt tcttttccta tttctttttt ttaagggtta gtattaacaa atggcaatga   2640

gtagaaaagt taacatgaag attttagaag gagagaactt acaggacaca gatttgtgat   2700

tctttgactg tgacactatt ggatgtgatt ctaaaagctt ttattgagca ttgtcaaatt   2760

tgtaagcttc atagggatgg acatcatatc tataatgccc ttctatatgt gctaccatag   2820

atgtgacatt tttgacctta atatcgtctt tgaaaatgtt aaattgagaa acctgttaac   2880

ttacatttta tgaattggca cattgtatta cttactgcaa gagatatttc attttcagca   2940

cagtgcaaaa gttctttaaa atgcatatgt ctttttttct aattccgttt tgttttaaag   3000

cacattttaa atgtagtttt ctcatttagt aaaagttgtc taattgatat g            3051


<210>  7654
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  7654

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                165                 170                 175     


Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
            180                 185                 190         


Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
        195                 200                 205             


Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
    210                 215                 220                 


Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
    290                 295                 300                 


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
305                 310                 315                 320 


Ala Asn Pro Pro Lys Lys Arg 
                325         


<210>  7655
<211>  3672
<212>  DNA
<213>  Homosapiens

<400>  7655
gcgggtgggg ccgtcggcgg cgctggtgag ctttgcggag ctgggcggtg ccgaggagga     60

ggaggtggcg gcctgggtct gacgcggccc tgttcgaggg ggcctctctt gtttatttat    120

ttattttccg tgggtgcctc cgagtgtgcg cgcgctctcg ctacccggcg gggagggggt    180

ggggggaggg cccgggaaaa gggggagttg gagccggggt cgaaacgccg cgtgacttgt    240

aggtgagaga acgccgagcc gtcgccgcag cctccgccgc cgagaagccc ttgttcccgc    300

tgctgggaag gagagtctgt gccgacaaga tggcggacgg ggagctgaac gtggacagcc    360

tcatcacccg gctgctggag gtacgaggat gtcgtccagg aaagattgtg cagatgactg    420

aagcagaagt tcgaggctta tgtatcaagt ctcgggagat ctttctcagc cagcctattc    480

ttttggaatt ggaagcaccg ctgaaaattt gtggagatat tcatggacaa tatacagatt    540

tactgagatt atttgaatat ggaggtttcc caccagaagc caactatctt ttcttaggag    600

attatgtgga cagaggaaag cagtctttgg aaaccatttg tttgctattg gcttataaaa    660

tcaaatatcc agagaacttc tttctcttaa gaggaaacca tgagtgtgct agcatcaatc    720

gcatttatgg attctatgat gaatgcaaac gaagatttaa tattaaattg tggaagacct    780

tcactgattg ttttaactgt ctgcctatag cagccattgt ggatgagaag atcttctgtt    840

gtcatggagg attgtcacca gacctgcaat ctatggagca gattcggaga attatgagac    900

ctactgatgt ccctgataca ggtttgctct gtgatttgct atggtctgat ccagataagg    960

atgtgcaagg ctggggagaa aatgatcgtg gtgtttcctt tacttttgga gctgatgtag   1020

tcagtaaatt tctgaatcgt catgatttag atttgatttg tcgagctcat caggtggtgg   1080

aagatggata tgaatttttt gctaaacgac agttggtaac cttattttca gccccaaatt   1140

actgtggcga gtttgataat gctggtggaa tgatgagtgt ggatgaaact ttgatgtgtt   1200

catttcagat attgaaacca tctgaaaaga aagctaaata ccagtatggt ggactgaatt   1260

ctggacgtcc tgtcactcca cctcgaacag ctaatccgcc gaagaaaagg tgaagaaagg   1320

aattctgtaa agaaaccatc agatttgtta aggacatact tcataatata taagtgtgca   1380

ctgtaaaacc atccagccat ttgacaccct ttatgatgtc acacctttaa cttaaggaga   1440

cgggtaaagg atcttaaatt tttttctaat agaaagatgt gctacactgt attgtaataa   1500

gtatactctg ttatagtcaa caaagttaaa tccaaattca aaattatcca ttaaagttac   1560

atcttcatgt atcacaattt ttaaagttga aaagcatccc agttaaacta gatgtgatag   1620

ttaaaccaga tgaaagcatg atgatccatc tgtgtaatgt ggttttagtg ttgcttggtt   1680

gtttaattat tttgagcttg ttttgttttt gtttgttttc actagaataa tggcaaatac   1740

ttctaatttt tttccctaaa catttttaaa agtgaaatat gggaagagct ttacagacat   1800

tcaccaacta ttattttccc ttgtttatct acttagatat ctgtttaatc ttactaagaa   1860

aactttcgcc tcattacatt aaaaaggaat tttagagatt gattgtttta aaaaaaaata   1920

cgcacattgt ccaatccagt gattttaatc atacagtttg actgggcaaa ctttacagct   1980

gatagtgaat attttgcttt atacaggaat tgacactgat ttggatttgt gcactctaat   2040

ttttaactta ttgatgctct attgtgcagt agcatttcat ttaagataag gctcatatag   2100

tattacccaa ctagttggta atgtgattat gtggtacctt ggctttaggt tttcattcgc   2160

acggaacacc ttttggcatg cttaacttcc tggtaacacc ttcacctgca ttggttttct   2220

ttttcttttt tctttctttt tttttttttt tttttttttg agttgttgtt tgtttttaga   2280

tccacagtac atgagaatcc ttttttgaca agccttggaa agctgacact gtctcttttt   2340

cctccctcta tacgaaggat gtatttaaat gaatgctggt cagtgggaca ttttgtcaac   2400

tatgggtatt gggtgcttaa ctgtctaata ttgccatgtg aatgttgtat acgattgtaa   2460

ggcttatgtc actaaagatt tttattctga ttttttcata atcaaaggtc atatgatact   2520

gtatagacaa gctttgtagt gaagtatagt agcaataatt tctgtacctg atcaagttta   2580

ttgcagcctt tcttttccta tttctttttt ttaagggtta gtattaacaa atggcaatga   2640

gtagaaaagt taacatgaag attttagaag gagagaactt acaggacaca gatttgtgat   2700

tctttgactg tgacactatt ggatgtgatt ctaaaagctt ttattgagca ttgtcaaatt   2760

tgtaagcttc atagggatgg acatcatatc tataatgccc ttctatatgt gctaccatag   2820

atgtgacatt tttgacctta atatcgtctt tgaaaatgtt aaattgagaa acctgttaac   2880

ttacatttta tgaattggca cattgtatta cttactgcaa gagatatttc attttcagca   2940

cagtgcaaaa gttctttaaa atgcatatgt ctttttttct aattccgttt tgttttaaag   3000

cacattttaa atgtagtttt ctcatttagt aaaagttgtc taattgatat gaagcctgac   3060

tgattttttt tttccttaca gtgagacatt taagcacaca ttttattcac atagatacta   3120

tgtccttgac atattgaaat gattcttttc tgaaagtatt catgatctgc atatgatgta   3180

ttaggttagg tcacaaaggt tttatctgag gtgatttaaa taacttcctg attggagtgt   3240

gtaagctgag cgatttctaa taaaatttta gttgtacact tttagtagtc atagtgaagc   3300

aggtctagaa aataagcctt tggcagggaa aaagggcaat gttgattaat ctcagtatta   3360

aaccacatta atctgtatcc cattgtctgg cttttgtaaa ttcatccagg tcaagactaa   3420

gtatgttggt taataggaat cctttttttt ttttttaaag actaaatgtg aaaaaataat   3480

cactacttaa gctaattaat attggtcatt aaatttaaag gatggaaatt tatcatgttt   3540

aaaaattatt caagcactct taaaaccact taaacagcct ccagtcataa aaatgtgttc   3600

tttacaaata tttgcttggc aacacgactt gaaataaata aaactttgtt tcttaggaga   3660

aaatgattct gt                                                       3672


<210>  7656
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  7656

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                165                 170                 175     


Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
            180                 185                 190         


Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
        195                 200                 205             


Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
    210                 215                 220                 


Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
    290                 295                 300                 


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
305                 310                 315                 320 


Ala Asn Pro Pro Lys Lys Arg 
                325         


<210>  7657
<211>  2846
<212>  DNA
<213>  Homosapiens

<400>  7657
gcgggtgggg ccgtcggcgg cgctggtgag ctttgcggag ctgggcggtg ccgaggagga     60

ggaggtggcg gcctgggtct gacgcggccc tgttcgaggg ggcctctctt gtttatttat    120

ttattttccg tgggtgcctc cgagtgtgcg cgcgctctcg ctacccggcg gggagggggt    180

ggggggaggg cccgggaaaa gggggagttg gagccggggt cgaaacgccg cgtgacttgt    240

aggtgagaga acgccgagcc gtcgccgcag cctccgccgc cgagaagccc ttgttcccgc    300

tgctgggaag gagagtctgt gccgacaaga tggcggacgg ggagctgaac gtggacagcc    360

tcatcacccg gctgctggag agatattgaa accatctgaa aagaaagcta aataccagta    420

tggtggactg aattctggac gtcctgtcac tccacctcga acagctaatc cgccgaagaa    480

aaggtgaaga aaggaattct gtaaagaaac catcagattt gttaaggaca tacttcataa    540

tatataagtg tgcactgtaa aaccatccag ccatttgaca ccctttatga tgtcacacct    600

ttaacttaag gagacgggta aaggatctta aatttttttc taatagaaag atgtgctaca    660

ctgtattgta ataagtatac tctgttatag tcaacaaagt taaatccaaa ttcaaaatta    720

tccattaaag ttacatcttc atgtatcaca atttttaaag ttgaaaagca tcccagttaa    780

actagatgtg atagttaaac cagatgaaag catgatgatc catctgtgta atgtggtttt    840

agtgttgctt ggttgtttaa ttattttgag cttgttttgt ttttgtttgt tttcactaga    900

ataatggcaa atacttctaa tttttttccc taaacatttt taaaagtgaa atatgggaag    960

agctttacag acattcacca actattattt tcccttgttt atctacttag atatctgttt   1020

aatcttacta agaaaacttt cgcctcatta cattaaaaag gaattttaga gattgattgt   1080

tttaaaaaaa aatacgcaca ttgtccaatc cagtgatttt aatcatacag tttgactggg   1140

caaactttac agctgatagt gaatattttg ctttatacag gaattgacac tgatttggat   1200

ttgtgcactc taatttttaa cttattgatg ctctattgtg cagtagcatt tcatttaaga   1260

taaggctcat atagtattac ccaactagtt ggtaatgtga ttatgtggta ccttggcttt   1320

aggttttcat tcgcacggaa caccttttgg catgcttaac ttcctggtaa caccttcacc   1380

tgcattggtt ttctttttct tttttctttc tttttttttt tttttttttt tttgagttgt   1440

tgtttgtttt tagatccaca gtacatgaga atcctttttt gacaagcctt ggaaagctga   1500

cactgtctct ttttcctccc tctatacgaa ggatgtattt aaatgaatgc tggtcagtgg   1560

gacattttgt caactatggg tattgggtgc ttaactgtct aatattgcca tgtgaatgtt   1620

gtatacgatt gtaaggctta tgtcactaaa gatttttatt ctgatttttt cataatcaaa   1680

ggtcatatga tactgtatag acaagctttg tagtgaagta tagtagcaat aatttctgta   1740

cctgatcaag tttattgcag cctttctttt cctatttctt ttttttaagg gttagtatta   1800

acaaatggca atgagtagaa aagttaacat gaagatttta gaaggagaga acttacagga   1860

cacagatttg tgattctttg actgtgacac tattggatgt gattctaaaa gcttttattg   1920

agcattgtca aatttgtaag cttcataggg atggacatca tatctataat gcccttctat   1980

atgtgctacc atagatgtga catttttgac cttaatatcg tctttgaaaa tgttaaattg   2040

agaaacctgt taacttacat tttatgaatt ggcacattgt attacttact gcaagagata   2100

tttcattttc agcacagtgc aaaagttctt taaaatgcat atgtcttttt ttctaattcc   2160

gttttgtttt aaagcacatt ttaaatgtag ttttctcatt tagtaaaagt tgtctaattg   2220

atatgaagcc tgactgattt tttttttcct tacagtgaga catttaagca cacattttat   2280

tcacatagat actatgtcct tgacatattg aaatgattct tttctgaaag tattcatgat   2340

ctgcatatga tgtattaggt taggtcacaa aggttttatc tgaggtgatt taaataactt   2400

cctgattgga gtgtgtaagc tgagcgattt ctaataaaat tttagttgta cacttttagt   2460

agtcatagtg aagcaggtct agaaaataag cctttggcag ggaaaaaggg caatgttgat   2520

taatctcagt attaaaccac attaatctgt atcccattgt ctggcttttg taaattcatc   2580

caggtcaaga ctaagtatgt tggttaatag gaatcctttt tttttttttt aaagactaaa   2640

tgtgaaaaaa taatcactac ttaagctaat taatattggt cattaaattt aaaggatgga   2700

aatttatcat gtttaaaaat tattcaagca ctcttaaaac cacttaaaca gcctccagtc   2760

ataaaaatgt gttctttaca aatatttgct tggcaacacg acttgaaata aataaaactt   2820

tgtttcttag gagaaaatga ttctgt                                        2846


<210>  7658
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  7658

Met Asp Ile Ile Ser Ile Met Pro Phe Tyr Met Cys Tyr His Arg Cys 
1               5                   10                  15      


Asp Ile Phe Asp Leu Asn Ile Val Phe Glu Asn Val Lys Leu Arg Asn 
            20                  25                  30          


Leu Leu Thr Tyr Ile Leu 
        35              


<210>  7659
<211>  4810
<212>  DNA
<213>  Homosapiens

<400>  7659
gcgggtgggg ccgtcggcgg cgctggtgag ctttgcggag ctgggcggtg ccgaggagga     60

ggaggtggcg gcctgggtct gacgcggccc tgttcgaggg ggcctctctt gtttatttat    120

ttattttccg tgggtgcctc cgagtgtgcg cgcgctctcg ctacccggcg gggagggggt    180

ggggggaggg cccgggaaaa gggggagttg gagccggggt cgaaacgccg cgtgacttgt    240

aggtgagaga acgccgagcc gtcgccgcag cctccgccgc cgagaagccc ttgttcccgc    300

tgctgggaag gagagtctgt gccgacaaga tggcggacgg ggagctgaac gtggacagcc    360

tcatcacccg gctgctggag gtacgaggat gtcgtccagg aaagattgtg cagatgactg    420

aagcagaagt tcgaggctta tgtatcaagt ctcgggagat ctttctcagc cagcctattc    480

ttttggaatt ggaagcaccg ctgaaaattt gtggagatat tcatggacaa tatacagatt    540

tactgagatt atttgaatat ggaggtttcc caccagaagc caactatctt ttcttaggag    600

attatgtgga cagaggaaag cagtctttgg aaaccatttg tttgctattg gcttataaaa    660

tcaaatatcc agagaacttc tttctcttaa gaggaaacca tgagtgtgct agcatcaatc    720

gcatttatgg attctatgat gaatgcaaac gaagatttaa tattaaattg tggaagacct    780

tcactgattg ttttaactgt ctgcctatag cagccattgt ggatgagaag atcttctgtt    840

gtcatggagg attgtcacca gacctgcaat ctatggagca gattcggaga attatgagac    900

ctactgatgt ccctgataca ggtttgctct gtgatttgct atggtctgat ccagataagg    960

atgtgcaagg ctggggagaa aatgatcgtg gtgtttcctt tacttttgga gctgatgtag   1020

tcagtaaatt tctgaatcgt catgatttag atttgatttg tcgagctcat caggtggtgg   1080

aagatggata tgaatttttt gctaaacgac agttggtaac cttattttca gccccaaatt   1140

actgtggcga gtttgataat gctggtggaa tgatgagtgt ggatgaaact ttgatgtgtt   1200

catttcagat attgaaacca tctgaaaaga aagctaaata ccagtatggt ggactgaatt   1260

ctggacgtcc tgtcactcca cctcgaacag ctaatccgcc gaagaaaagg tgaagaaagg   1320

aattctgtaa agaaaccatc agatttgtta aggacatact tcataatata taagtgtgca   1380

ctgtaaaacc atccagccat ttgacaccct ttatgatgtc acacctttaa cttaaggaga   1440

cgggtaaagg atcttaaatt tttttctaat agaaagatgt gctacactgt attgtaataa   1500

gtatactctg ttatagtcaa caaagttaaa tccaaattca aaattatcca ttaaagttac   1560

atcttcatgt atcacaattt ttaaagttga aaagcatccc agttaaacta gatgtgatag   1620

ttaaaccaga tgaaagcatg atgatccatc tgtgtaatgt ggttttagtg ttgcttggtt   1680

gtttaattat tttgagcttg ttttgttttt gtttgttttc actagaataa tggcaaatac   1740

ttctaatttt tttccctaaa catttttaaa agtgaaatat gggaagagct ttacagacat   1800

tcaccaacta ttattttccc ttgtttatct acttagatat ctgtttaatc ttactaagaa   1860

aactttcgcc tcattacatt aaaaaggaat tttagagatt gattgtttta aaaaaaaata   1920

cgcacattgt ccaatccagt gattttaatc atacagtttg actgggcaaa ctttacagct   1980

gatagtgaat attttgcttt atacaggaat tgacactgat ttggatttgt gcactctaat   2040

ttttaactta ttgatgctct attgtgcagt agcatttcat ttaagataag gctcatatag   2100

tattacccaa ctagttggta atgtgattat gtggtacctt ggctttaggt tttcattcgc   2160

acggaacacc ttttggcatg cttaacttcc tggtaacacc ttcacctgca ttggttttct   2220

ttttcttttt tctttctttt tttttttttt tttttttttg agttgttgtt tgtttttaga   2280

tccacagtac atgagaatcc ttttttgaca agccttggaa agctgacact gtctcttttt   2340

cctccctcta tacgaaggat gtatttaaat gaatgctggt cagtgggaca ttttgtcaac   2400

tatgggtatt gggtgcttaa ctgtctaata ttgccatgtg aatgttgtat acgattgtaa   2460

ggcttatgtc actaaagatt tttattctga ttttttcata atcaaaggtc atatgatact   2520

gtatagacaa gctttgtagt gaagtatagt agcaataatt tctgtacctg atcaagttta   2580

ttgcagcctt tcttttccta tttctttttt ttaagggtta gtattaacaa atggcaatga   2640

gtagaaaagt taacatgaag attttagaag gagagaactt acaggacaca gatttgtgat   2700

tctttgactg tgacactatt ggatgtgatt ctaaaagctt ttattgagca ttgtcaaatt   2760

tgtaagcttc atagggatgg acatcatatc tataatgccc ttctatatgt gctaccatag   2820

atgtgacatt tttgacctta atatcgtctt tgaaaatgtt aaattgagaa acctgttaac   2880

ttacatttta tgaattggca cattgtatta cttactgcaa gagatatttc attttcagca   2940

cagtgcaaaa gttctttaaa atgcatatgt ctttttttct aattccgttt tgttttaaag   3000

cacattttaa atgtagtttt ctcatttagt aaaagttgtc taattgatat gaagcctgac   3060

tgattttttt tttccttaca gtgagacatt taagcacaca ttttattcac atagatacta   3120

tgtccttgac atattgaaat gattcttttc tgaaagtatt catgatctgc atatgatgta   3180

ttaggttagg tcacaaaggt tttatctgag gtgatttaaa taacttcctg attggagtgt   3240

gtaagctgag cgatttctaa taaaatttta gttgtacact tttagtagtc atagtgaagc   3300

aggtctagaa aataagcctt tggcagggaa aaagggcaat gttgattaat ctcagtatta   3360

aaccacatta atctgtatcc cattgtctgg cttttgtaaa ttcatccagg tcaagactaa   3420

gtatgttggt taataggaat cctttttttt ttttttaaag actaaatgtg aaaaaataat   3480

cactacttaa gctaattaat attggtcatt aaatttaaag gatggaaatt tatcatgttt   3540

aaaaattatt caagcactct taaaaccact taaacagcct ccagtcataa aaatgtgttc   3600

tttacaaata tttgcttggc aacacgactt gaaataaata aaactttgtt tcttaggaga   3660

aaatgattct gtaattccag tgtcactaat ttatattgtt ctttcctctg atttttttca   3720

ggttagtgat ttttttgtat acaatttaat ccaaatgtta tgacattcag aaatcatgaa   3780

acacagtaga tatctgttat aatgtggtgt atcacatgga ttataaagca aagttatggt   3840

cgatttctat tcttgaaaga atcaactaca gtgaatcctt tgcatttgaa gccttaacat   3900

gcattgcttt aattttgccc agggacaaat tttaataatc agcaagactg gtttgtgcaa   3960

agcgttgagt catcaggtat ttagagccta gccagctacc cagtatccat gctgccatat   4020

cccttcattg taaaaagtac ctaaacattc gtgaaatgat tttttttagc tgaaaaatgc   4080

tggcaagaag aattttaaag cttaaaatag gtggtaaatt tgaagtatga gtgtgttcac   4140

gagaaacata ggcttttcaa aaaaattttt attcaaggca aagcaaggaa catcttgaga   4200

tatgtctcaa gaatataaag atgtattatt ttaagccaag gagctgaaat atatctcagt   4260

ttataaattc aggtatattc tttttgtctc catggcaacc ataacttttg aaccaaaaaa   4320

aattgttttt acatctttat gctgaaaatg tgtttagatt aggaatatgg tcgggctgaa   4380

tttgctgttg ctccctaacc aaatccacct cttgttttcc ttgtgagtcc atggctaaat   4440

caaagctgcc cctgagaaga gacttaatcc aagcctgatt gtactagtgg catcacttag   4500

aagtaggctt tccctcttcc tagtagatct caatgtttta taattcctta aaacagctga   4560

aaattgggac aacatacttt acgcaatgaa cagtagttaa ataggaaata aactagttcc   4620

atataagtat acacctagag ttttaattac ctttataatg tttcttaaaa gtgaaactta   4680

gatacaattg tgattggata cttagatact aagtgaaact tagtgtaaca attttgatct   4740

gttaaattgg attttacatg tacatttgaa tgccagaatt tctaaataaa tcccctggtt   4800

aggaaatttt                                                          4810


<210>  7660
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  7660

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                165                 170                 175     


Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
            180                 185                 190         


Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
        195                 200                 205             


Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
    210                 215                 220                 


Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
    290                 295                 300                 


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
305                 310                 315                 320 


Ala Asn Pro Pro Lys Lys Arg 
                325         


<210>  7661
<211>  3541
<212>  DNA
<213>  Homosapiens

<400>  7661
ggcgctggtg agctttgcgg agctgggcgg tgccgaggag gaggaggtgg cggcctgggt     60

ctgacgcggc cctgttcgag ggggcctctc ttgtttattt atttattttc cgtgagagaa    120

cgccgagccg tcgccgcagc ctccgccgcc gagaagccct tgttcccgct gctgggaagg    180

agagtctgtg ccgacaagat ggcggacggg gagctgaacg tggacagcct catcacccgg    240

ctgctggagg tacgaggatg tcgtccagga aagattgtgc agatgactga agcagaagtt    300

cgaggcttat gtatcaagtc tcgggagatc tttctcagcc agcctattct tttggaattg    360

gaagcaccgc tgaaaatttg tggagatatt catggacaat atacagattt actgagatta    420

tttgaatatg gaggtttccc accagaagcc aactatcttt tcttaggaga ttatgtggac    480

agaggaaagc agtctttgga aaccatttgt ttgctattgg cttataaaat caaatatcca    540

gagaacttct ttctcttaag aggaaaccat gagtgtgcta gcatcaatcg catttatgga    600

ttctatgatg aatgcaaacg aagatttaat attaaattgt ggaagacctt cactgattgt    660

tttaactgtc tgcctatagc agccattgtg gatgagaaga tcttctgttg tcatggagga    720

ttgtcaccag acctgcaatc tatggagcag attcggagaa ttatgagacc tactgatgtc    780

cctgatacag gtttgctctg tgatttgcta tggtctgatc cagataagga tgtgcaaggc    840

tggggagaaa atgatcgtgg tgtttccttt acttttggag ctgatgtagt cagtaaattt    900

ctgaatcgtc atgatttaga tttgatttgt cgagctcatc aggtggtgga agatggatat    960

gaattttttg ctaaacgaca gttggtaacc ttattttcag ccccaaatta ctgtggcgag   1020

tttgataatg ctggtggaat gatgagtgtg gatgaaactt tgatgtgttc atttcagata   1080

ttgaaaccat ctgaaaagaa agctaaatac cagtatggtg gactgaattc tggacgtcct   1140

gtcactccac ctcgaacagc taatccgccg aagaaaaggt gaagaaagga attctgtaaa   1200

gaaaccatca gatttgttaa ggacatactt cataatatat aagtgtgcac tgtaaaacca   1260

tccagccatt tgacaccctt tatgatgtca cacctttaac ttaaggagac gggtaaagga   1320

tcttaaattt ttttctaata gaaagatgtg ctacactgta ttgtaataag tatactctgt   1380

tatagtcaac aaagttaaat ccaaattcaa aattatccat taaagttaca tcttcatgta   1440

tcacaatttt taaagttgaa aagcatccca gttaaactag atgtgatagt taaaccagat   1500

gaaagcatga tgatccatct gtgtaatgtg gttttagtgt tgcttggttg tttaattatt   1560

ttgagcttgt tttgtttttg tttgttttca ctagaataat ggcaaatact tctaattttt   1620

ttccctaaac atttttaaaa gtgaaatatg ggaagagctt tacagacatt caccaactat   1680

tattttccct tgtttatcta cttagatatc tgtttaatct tactaagaaa actttcgcct   1740

cattacatta aaaaggaatt ttagagattg attgttttaa aaaaaaatac gcacattgtc   1800

caatccagtg attttaatca tacagtttga ctgggcaaac tttacagctg atagtgaata   1860

ttttgcttta tacaggaatt gacactgatt tggatttgtg cactctaatt tttaacttat   1920

tgatgctcta ttgtgcagta gcatttcatt taagataagg ctcatatagt attacccaac   1980

tagttggtaa tgtgattatg tggtaccttg gctttaggtt ttcattcgca cggaacacct   2040

tttggcatgc ttaacttcct ggtaacacct tcacctgcat tggttttctt tttctttttt   2100

ctttcttttt tttttttttt ttttttttga gttgttgttt gtttttagat ccacagtaca   2160

tgagaatcct tttttgacaa gccttggaaa gctgacactg tctctttttc ctccctctat   2220

acgaaggatg tatttaaatg aatgctggtc agtgggacat tttgtcaact atgggtattg   2280

ggtgcttaac tgtctaatat tgccatgtga atgttgtata cgattgtaag gcttatgtca   2340

ctaaagattt ttattctgat tttttcataa tcaaaggtca tatgatactg tatagacaag   2400

ctttgtagtg aagtatagta gcaataattt ctgtacctga tcaagtttat tgcagccttt   2460

cttttcctat ttcttttttt taagggttag tattaacaaa tggcaatgag tagaaaagtt   2520

aacatgaaga ttttagaagg agagaactta caggacacag atttgtgatt ctttgactgt   2580

gacactattg gatgtgattc taaaagcttt tattgagcat tgtcaaattt gtaagcttca   2640

tagggatgga catcatatct ataatgccct tctatatgtg ctaccataga tgtgacattt   2700

ttgaccttaa tatcgtcttt gaaaatgtta aattgagaaa cctgttaact tacattttat   2760

gaattggcac attgtattac ttactgcaag agatatttca ttttcagcac agtgcaaaag   2820

ttctttaaaa tgcatatgtc tttttttcta attccgtttt gttttaaagc acattttaaa   2880

tgtagttttc tcatttagta aaagttgtct aattgatatg aagcctgact gatttttttt   2940

ttccttacag tgagacattt aagcacacat tttattcaca tagatactat gtccttgaca   3000

tattgaaatg attcttttct gaaagtattc atgatctgca tatgatgtat taggttaggt   3060

cacaaaggtt ttatctgagg tgatttaaat aacttcctga ttggagtgtg taagctgagc   3120

gatttctaat aaaattttag ttgtacactt ttagtagtca tagtgaagca ggtctagaaa   3180

ataagccttt ggcagggaaa aagggcaatg ttgattaatc tcagtattaa accacattaa   3240

tctgtatccc attgtctggc ttttgtaaat tcatccaggt caagactaag tatgttggtt   3300

aataggaatc cttttttttt tttttaaaga ctaaatgtga aaaaataatc actacttaag   3360

ctaattaata ttggtcatta aatttaaagg atggaaattt atcatgttta aaaattattc   3420

aagcactctt aaaaccactt aaacagcctc cagtcataaa aatgtgttct ttacaaatat   3480

ttgcttggca acacgacttg aaataaataa aactttgttt cttaggagaa aatgattctg   3540

t                                                                   3541


<210>  7662
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  7662

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                165                 170                 175     


Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
            180                 185                 190         


Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
        195                 200                 205             


Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
    210                 215                 220                 


Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
    290                 295                 300                 


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
305                 310                 315                 320 


Ala Asn Pro Pro Lys Lys Arg 
                325         


<210>  7663
<211>  938
<212>  DNA
<213>  Homosapiens

<400>  7663
gggcggtgcc gaggaggagg aggtggcggc ctgggtgaga gaacgccgag ccgtcgccgc     60

agcctccgcc gccgagaagc ccttgttccc gctgctggga aggagagtct gtgccgacaa    120

gatggcggac ggggagctga acgtggacag cctcatcacc cggcttgtct gcctatagca    180

gccattgtgg atgagaagat cttctgttgt catggaggat tgtcaccaga cctgcaatct    240

atggagcaga ttcggagaat tatgagacct actgatgtcc ctgatacagg tttgctctgt    300

gatttgctat ggtctgatcc agataaggat gtgcaaggct ggggagaaaa tgatcgtggt    360

gtttccttta cttttggagc tgatgtagtc agtaaatttc tgaatcgtca tgatttagat    420

ttgatttgtc gagctcatca ggtggtggaa gatggatatg aattttttgc taaacgacag    480

ttggtaacct tattttcagc cccaaattac tgtggcgagt ttgataatgc tggtggaatg    540

atgagtgtgg atgaaacttt gatgtgttca tttcagatat tgaaaccatc tgaaaagaaa    600

gctaaatacc agtatggtgg actgaattct ggacgtcctg tcactccacc tcgaacagct    660

aatccgccga agaaaaggtg aagaaaggaa ttctgtaaag aaaccatcag atttgttaag    720

gacatacttc ataatatata agtgtgcact gtaaaaccat ccagccattt gacacccttt    780

atgatgtcac acctttaact taaggagacg ggtaaaggat cttaaatttt tttctaatag    840

aaagatgtgc tacactgtat tgtaataagt atactctgtt atagtcaaca aagttaaatc    900

caaattcaaa attatccatt aaagttacat cttcatgt                            938


<210>  7664
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  7664

Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr Asp Val Pro Asp Thr 
1               5                   10                  15      


Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro Asp Lys Asp Val Gln 
            20                  25                  30          


Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe Thr Phe Gly Ala Asp 
        35                  40                  45              


Val Val Ser Lys Phe Leu Asn Arg His Asp Leu Asp Leu Ile Cys Arg 
    50                  55                  60                  


Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe Phe Ala Lys Arg Gln 
65                  70                  75                  80  


Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys Gly Glu Phe Asp Asn 
                85                  90                  95      


Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu Met Cys Ser Phe Gln 
            100                 105                 110         


Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr Gln Tyr Gly Gly Leu 
        115                 120                 125             


Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr Ala Asn Pro Pro Lys 
    130                 135                 140                 


Lys Arg 
145     


<210>  7665
<211>  2419
<212>  DNA
<213>  Homosapiens

<400>  7665
gggcggtgcc gaggaggagg aggtggcggc ctgggtgaga gaacgccgag ccgtcgccgc     60

agcctccgcc gccgagaagc ccttgttccc gctgctggga aggagagtct gtgccgacaa    120

gatggcggac ggggagctga acgtggacag cctcatcacc cggcttgtct gcctatagca    180

gccattgtgg atgagaagat cttctgttgt catggaggat tgtcaccaga cctgcaatct    240

atggagcaga ttcggagaat tatgagacct actgatgtcc ctgatacagg tttgctctgt    300

gatttgctat ggtctgatcc agataaggat gtgcaaggct ggggagaaaa tgatcgtggt    360

gtttccttta cttttggagc tgatgtagtc agtaaatttc tgaatcgtca tgatttagat    420

ttgatttgtc gagctcatca ggtggtggaa gatggatatg aattttttgc taaacgacag    480

ttggtaacct tattttcagc cccaaattac tgtggcgagt ttgataatgc tggtggaatg    540

atgagtgtgg atgaaacttt gatgtgttca tttcagatat tgaaaccatc tgaaaagaaa    600

gctaaatacc agtatggtgg actgaattct ggacgtcctg tcactccacc tcgaacagct    660

aatccgccga agaaaaggtg aagaaaggaa ttctgtaaag aaaccatcag atttgttaag    720

gacatacttc ataatatata agtgtgcact gtaaaaccat ccagccattt gacacccttt    780

atgatgtcac acctttaact taaggagacg ggtaaaggat cttaaatttt tttctaatag    840

aaagatgtgc tacactgtat tgtaataagt atactctgtt atagtcaaca aagttaaatc    900

caaattcaaa attatccatt aaagttacat cttcatgtat cacaattttt aaagttgaaa    960

agcatcccag ttaaactaga tgtgatagtt aaaccagatg aaagcatgat gatccatctg   1020

tgtaatgtgg ttttagtgtt gcttggttgt ttaattattt tgagcttgtt ttgtttttgt   1080

ttgttttcac tagaataatg gcaaatactt ctaatttttt tccctaaaca tttttaaaag   1140

tgaaatatgg gaagagcttt acagacattc accaactatt attttccctt gtttatctac   1200

ttagatatct gtttaatctt actaagaaaa ctttcgcctc attacattaa aaaggaattt   1260

tagagattga ttgttttaaa aaaaaatacg cacattgtcc aatccagtga ttttaatcat   1320

acagtttgac tgggcaaact ttacagctga tagtgaatat tttgctttat acaggaattg   1380

acactgattt ggatttgtgc actctaattt ttaacttatt gatgctctat tgtgcagtag   1440

catttcattt aagataaggc tcatatagta ttacccaact agttggtaat gtgattatgt   1500

ggtaccttgg ctttaggttt tcattcgcac ggaacacctt ttggcatgct taacttcctg   1560

gtaacacctt cacctgcatt ggttttcttt ttcttttttc tttctttttt tttttttttt   1620

tttttttgag ttgttgtttg tttttagatc cacagtacat gagaatcctt ttttgacaag   1680

ccttggaaag ctgacactgt ctctttttcc tccctctata cgaaggatgt atttaaatga   1740

atgctggtca gtgggacatt ttgtcaacta tgggtattgg gtgcttaact gtctaatatt   1800

gccatgtgaa tgttgtatac gattgtaagg cttatgtcac taaagatttt tattctgatt   1860

ttttcataat caaaggtcat atgatactgt atagacaagc tttgtagtga agtatagtag   1920

caataatttc tgtacctgat caagtttatt gcagcctttc ttttcctatt tctttttttt   1980

aagggttagt attaacaaat ggcaatgagt agaaaagtta acatgaagat tttagaagga   2040

gagaacttac aggacacaga tttgtgattc tttgactgtg acactattgg atgtgattct   2100

aaaagctttt attgagcatt gtcaaatttg taagcttcat agggatggac atcatatcta   2160

taatgccctt ctatatgtgc taccatagat gtgacatttt tgaccttaat atcgtctttg   2220

aaaatgttaa attgagaaac ctgttaactt acattttatg aattggcaca ttgtattact   2280

tactgcaaga gatatttcat tttcagcaca gtgcaaaagt tctttaaaat gcatatgtct   2340

ttttttctaa ttccgttttg ttttaaagca cattttaaat gtagttttct catttagtaa   2400

aagttgtcta attgatatg                                                2419


<210>  7666
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  7666

Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr Asp Val Pro Asp Thr 
1               5                   10                  15      


Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro Asp Lys Asp Val Gln 
            20                  25                  30          


Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe Thr Phe Gly Ala Asp 
        35                  40                  45              


Val Val Ser Lys Phe Leu Asn Arg His Asp Leu Asp Leu Ile Cys Arg 
    50                  55                  60                  


Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe Phe Ala Lys Arg Gln 
65                  70                  75                  80  


Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys Gly Glu Phe Asp Asn 
                85                  90                  95      


Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu Met Cys Ser Phe Gln 
            100                 105                 110         


Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr Gln Tyr Gly Gly Leu 
        115                 120                 125             


Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr Ala Asn Pro Pro Lys 
    130                 135                 140                 


Lys Arg 
145     


<210>  7667
<211>  3040
<212>  DNA
<213>  Homosapiens

<400>  7667
gggcggtgcc gaggaggagg aggtggcggc ctgggtgaga gaacgccgag ccgtcgccgc     60

agcctccgcc gccgagaagc ccttgttccc gctgctggga aggagagtct gtgccgacaa    120

gatggcggac ggggagctga acgtggacag cctcatcacc cggcttgtct gcctatagca    180

gccattgtgg atgagaagat cttctgttgt catggaggat tgtcaccaga cctgcaatct    240

atggagcaga ttcggagaat tatgagacct actgatgtcc ctgatacagg tttgctctgt    300

gatttgctat ggtctgatcc agataaggat gtgcaaggct ggggagaaaa tgatcgtggt    360

gtttccttta cttttggagc tgatgtagtc agtaaatttc tgaatcgtca tgatttagat    420

ttgatttgtc gagctcatca ggtggtggaa gatggatatg aattttttgc taaacgacag    480

ttggtaacct tattttcagc cccaaattac tgtggcgagt ttgataatgc tggtggaatg    540

atgagtgtgg atgaaacttt gatgtgttca tttcagatat tgaaaccatc tgaaaagaaa    600

gctaaatacc agtatggtgg actgaattct ggacgtcctg tcactccacc tcgaacagct    660

aatccgccga agaaaaggtg aagaaaggaa ttctgtaaag aaaccatcag atttgttaag    720

gacatacttc ataatatata agtgtgcact gtaaaaccat ccagccattt gacacccttt    780

atgatgtcac acctttaact taaggagacg ggtaaaggat cttaaatttt tttctaatag    840

aaagatgtgc tacactgtat tgtaataagt atactctgtt atagtcaaca aagttaaatc    900

caaattcaaa attatccatt aaagttacat cttcatgtat cacaattttt aaagttgaaa    960

agcatcccag ttaaactaga tgtgatagtt aaaccagatg aaagcatgat gatccatctg   1020

tgtaatgtgg ttttagtgtt gcttggttgt ttaattattt tgagcttgtt ttgtttttgt   1080

ttgttttcac tagaataatg gcaaatactt ctaatttttt tccctaaaca tttttaaaag   1140

tgaaatatgg gaagagcttt acagacattc accaactatt attttccctt gtttatctac   1200

ttagatatct gtttaatctt actaagaaaa ctttcgcctc attacattaa aaaggaattt   1260

tagagattga ttgttttaaa aaaaaatacg cacattgtcc aatccagtga ttttaatcat   1320

acagtttgac tgggcaaact ttacagctga tagtgaatat tttgctttat acaggaattg   1380

acactgattt ggatttgtgc actctaattt ttaacttatt gatgctctat tgtgcagtag   1440

catttcattt aagataaggc tcatatagta ttacccaact agttggtaat gtgattatgt   1500

ggtaccttgg ctttaggttt tcattcgcac ggaacacctt ttggcatgct taacttcctg   1560

gtaacacctt cacctgcatt ggttttcttt ttcttttttc tttctttttt tttttttttt   1620

tttttttgag ttgttgtttg tttttagatc cacagtacat gagaatcctt ttttgacaag   1680

ccttggaaag ctgacactgt ctctttttcc tccctctata cgaaggatgt atttaaatga   1740

atgctggtca gtgggacatt ttgtcaacta tgggtattgg gtgcttaact gtctaatatt   1800

gccatgtgaa tgttgtatac gattgtaagg cttatgtcac taaagatttt tattctgatt   1860

ttttcataat caaaggtcat atgatactgt atagacaagc tttgtagtga agtatagtag   1920

caataatttc tgtacctgat caagtttatt gcagcctttc ttttcctatt tctttttttt   1980

aagggttagt attaacaaat ggcaatgagt agaaaagtta acatgaagat tttagaagga   2040

gagaacttac aggacacaga tttgtgattc tttgactgtg acactattgg atgtgattct   2100

aaaagctttt attgagcatt gtcaaatttg taagcttcat agggatggac atcatatcta   2160

taatgccctt ctatatgtgc taccatagat gtgacatttt tgaccttaat atcgtctttg   2220

aaaatgttaa attgagaaac ctgttaactt acattttatg aattggcaca ttgtattact   2280

tactgcaaga gatatttcat tttcagcaca gtgcaaaagt tctttaaaat gcatatgtct   2340

ttttttctaa ttccgttttg ttttaaagca cattttaaat gtagttttct catttagtaa   2400

aagttgtcta attgatatga agcctgactg attttttttt tccttacagt gagacattta   2460

agcacacatt ttattcacat agatactatg tccttgacat attgaaatga ttcttttctg   2520

aaagtattca tgatctgcat atgatgtatt aggttaggtc acaaaggttt tatctgaggt   2580

gatttaaata acttcctgat tggagtgtgt aagctgagcg atttctaata aaattttagt   2640

tgtacacttt tagtagtcat agtgaagcag gtctagaaaa taagcctttg gcagggaaaa   2700

agggcaatgt tgattaatct cagtattaaa ccacattaat ctgtatccca ttgtctggct   2760

tttgtaaatt catccaggtc aagactaagt atgttggtta ataggaatcc tttttttttt   2820

ttttaaagac taaatgtgaa aaaataatca ctacttaagc taattaatat tggtcattaa   2880

atttaaagga tggaaattta tcatgtttaa aaattattca agcactctta aaaccactta   2940

aacagcctcc agtcataaaa atgtgttctt tacaaatatt tgcttggcaa cacgacttga   3000

aataaataaa actttgtttc ttaggagaaa atgattctgt                         3040


<210>  7668
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  7668

Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr Asp Val Pro Asp Thr 
1               5                   10                  15      


Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro Asp Lys Asp Val Gln 
            20                  25                  30          


Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe Thr Phe Gly Ala Asp 
        35                  40                  45              


Val Val Ser Lys Phe Leu Asn Arg His Asp Leu Asp Leu Ile Cys Arg 
    50                  55                  60                  


Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe Phe Ala Lys Arg Gln 
65                  70                  75                  80  


Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys Gly Glu Phe Asp Asn 
                85                  90                  95      


Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu Met Cys Ser Phe Gln 
            100                 105                 110         


Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr Gln Tyr Gly Gly Leu 
        115                 120                 125             


Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr Ala Asn Pro Pro Lys 
    130                 135                 140                 


Lys Arg 
145     


<210>  7669
<211>  4178
<212>  DNA
<213>  Homosapiens

<400>  7669
gggcggtgcc gaggaggagg aggtggcggc ctgggtgaga gaacgccgag ccgtcgccgc     60

agcctccgcc gccgagaagc ccttgttccc gctgctggga aggagagtct gtgccgacaa    120

gatggcggac ggggagctga acgtggacag cctcatcacc cggcttgtct gcctatagca    180

gccattgtgg atgagaagat cttctgttgt catggaggat tgtcaccaga cctgcaatct    240

atggagcaga ttcggagaat tatgagacct actgatgtcc ctgatacagg tttgctctgt    300

gatttgctat ggtctgatcc agataaggat gtgcaaggct ggggagaaaa tgatcgtggt    360

gtttccttta cttttggagc tgatgtagtc agtaaatttc tgaatcgtca tgatttagat    420

ttgatttgtc gagctcatca ggtggtggaa gatggatatg aattttttgc taaacgacag    480

ttggtaacct tattttcagc cccaaattac tgtggcgagt ttgataatgc tggtggaatg    540

atgagtgtgg atgaaacttt gatgtgttca tttcagatat tgaaaccatc tgaaaagaaa    600

gctaaatacc agtatggtgg actgaattct ggacgtcctg tcactccacc tcgaacagct    660

aatccgccga agaaaaggtg aagaaaggaa ttctgtaaag aaaccatcag atttgttaag    720

gacatacttc ataatatata agtgtgcact gtaaaaccat ccagccattt gacacccttt    780

atgatgtcac acctttaact taaggagacg ggtaaaggat cttaaatttt tttctaatag    840

aaagatgtgc tacactgtat tgtaataagt atactctgtt atagtcaaca aagttaaatc    900

caaattcaaa attatccatt aaagttacat cttcatgtat cacaattttt aaagttgaaa    960

agcatcccag ttaaactaga tgtgatagtt aaaccagatg aaagcatgat gatccatctg   1020

tgtaatgtgg ttttagtgtt gcttggttgt ttaattattt tgagcttgtt ttgtttttgt   1080

ttgttttcac tagaataatg gcaaatactt ctaatttttt tccctaaaca tttttaaaag   1140

tgaaatatgg gaagagcttt acagacattc accaactatt attttccctt gtttatctac   1200

ttagatatct gtttaatctt actaagaaaa ctttcgcctc attacattaa aaaggaattt   1260

tagagattga ttgttttaaa aaaaaatacg cacattgtcc aatccagtga ttttaatcat   1320

acagtttgac tgggcaaact ttacagctga tagtgaatat tttgctttat acaggaattg   1380

acactgattt ggatttgtgc actctaattt ttaacttatt gatgctctat tgtgcagtag   1440

catttcattt aagataaggc tcatatagta ttacccaact agttggtaat gtgattatgt   1500

ggtaccttgg ctttaggttt tcattcgcac ggaacacctt ttggcatgct taacttcctg   1560

gtaacacctt cacctgcatt ggttttcttt ttcttttttc tttctttttt tttttttttt   1620

tttttttgag ttgttgtttg tttttagatc cacagtacat gagaatcctt ttttgacaag   1680

ccttggaaag ctgacactgt ctctttttcc tccctctata cgaaggatgt atttaaatga   1740

atgctggtca gtgggacatt ttgtcaacta tgggtattgg gtgcttaact gtctaatatt   1800

gccatgtgaa tgttgtatac gattgtaagg cttatgtcac taaagatttt tattctgatt   1860

ttttcataat caaaggtcat atgatactgt atagacaagc tttgtagtga agtatagtag   1920

caataatttc tgtacctgat caagtttatt gcagcctttc ttttcctatt tctttttttt   1980

aagggttagt attaacaaat ggcaatgagt agaaaagtta acatgaagat tttagaagga   2040

gagaacttac aggacacaga tttgtgattc tttgactgtg acactattgg atgtgattct   2100

aaaagctttt attgagcatt gtcaaatttg taagcttcat agggatggac atcatatcta   2160

taatgccctt ctatatgtgc taccatagat gtgacatttt tgaccttaat atcgtctttg   2220

aaaatgttaa attgagaaac ctgttaactt acattttatg aattggcaca ttgtattact   2280

tactgcaaga gatatttcat tttcagcaca gtgcaaaagt tctttaaaat gcatatgtct   2340

ttttttctaa ttccgttttg ttttaaagca cattttaaat gtagttttct catttagtaa   2400

aagttgtcta attgatatga agcctgactg attttttttt tccttacagt gagacattta   2460

agcacacatt ttattcacat agatactatg tccttgacat attgaaatga ttcttttctg   2520

aaagtattca tgatctgcat atgatgtatt aggttaggtc acaaaggttt tatctgaggt   2580

gatttaaata acttcctgat tggagtgtgt aagctgagcg atttctaata aaattttagt   2640

tgtacacttt tagtagtcat agtgaagcag gtctagaaaa taagcctttg gcagggaaaa   2700

agggcaatgt tgattaatct cagtattaaa ccacattaat ctgtatccca ttgtctggct   2760

tttgtaaatt catccaggtc aagactaagt atgttggtta ataggaatcc tttttttttt   2820

ttttaaagac taaatgtgaa aaaataatca ctacttaagc taattaatat tggtcattaa   2880

atttaaagga tggaaattta tcatgtttaa aaattattca agcactctta aaaccactta   2940

aacagcctcc agtcataaaa atgtgttctt tacaaatatt tgcttggcaa cacgacttga   3000

aataaataaa actttgtttc ttaggagaaa atgattctgt aattccagtg tcactaattt   3060

atattgttct ttcctctgat ttttttcagg ttagtgattt ttttgtatac aatttaatcc   3120

aaatgttatg acattcagaa atcatgaaac acagtagata tctgttataa tgtggtgtat   3180

cacatggatt ataaagcaaa gttatggtcg atttctattc ttgaaagaat caactacagt   3240

gaatcctttg catttgaagc cttaacatgc attgctttaa ttttgcccag ggacaaattt   3300

taataatcag caagactggt ttgtgcaaag cgttgagtca tcaggtattt agagcctagc   3360

cagctaccca gtatccatgc tgccatatcc cttcattgta aaaagtacct aaacattcgt   3420

gaaatgattt tttttagctg aaaaatgctg gcaagaagaa ttttaaagct taaaataggt   3480

ggtaaatttg aagtatgagt gtgttcacga gaaacatagg cttttcaaaa aaatttttat   3540

tcaaggcaaa gcaaggaaca tcttgagata tgtctcaaga atataaagat gtattatttt   3600

aagccaagga gctgaaatat atctcagttt ataaattcag gtatattctt tttgtctcca   3660

tggcaaccat aacttttgaa ccaaaaaaaa ttgtttttac atctttatgc tgaaaatgtg   3720

tttagattag gaatatggtc gggctgaatt tgctgttgct ccctaaccaa atccacctct   3780

tgttttcctt gtgagtccat ggctaaatca aagctgcccc tgagaagaga cttaatccaa   3840

gcctgattgt actagtggca tcacttagaa gtaggctttc cctcttccta gtagatctca   3900

atgttttata attccttaaa acagctgaaa attgggacaa catactttac gcaatgaaca   3960

gtagttaaat aggaaataaa ctagttccat ataagtatac acctagagtt ttaattacct   4020

ttataatgtt tcttaaaagt gaaacttaga tacaattgtg attggatact tagatactaa   4080

gtgaaactta gtgtaacaat tttgatctgt taaattggat tttacatgta catttgaatg   4140

ccagaatttc taaataaatc ccctggttag gaaatttt                           4178


<210>  7670
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  7670

Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr Asp Val Pro Asp Thr 
1               5                   10                  15      


Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro Asp Lys Asp Val Gln 
            20                  25                  30          


Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe Thr Phe Gly Ala Asp 
        35                  40                  45              


Val Val Ser Lys Phe Leu Asn Arg His Asp Leu Asp Leu Ile Cys Arg 
    50                  55                  60                  


Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe Phe Ala Lys Arg Gln 
65                  70                  75                  80  


Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys Gly Glu Phe Asp Asn 
                85                  90                  95      


Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu Met Cys Ser Phe Gln 
            100                 105                 110         


Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr Gln Tyr Gly Gly Leu 
        115                 120                 125             


Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr Ala Asn Pro Pro Lys 
    130                 135                 140                 


Lys Arg 
145     


<210>  7671
<211>  4322
<212>  DNA
<213>  Homosapiens

<400>  7671
gggcggtgcc gaggaggagg aggtggcggc ctgggtgaga gaacgccgag ccgtcgccgc     60

agcctccgcc gccgagaagc ccttgttccc gctgctggga aggagagtct gtgccgacaa    120

gatggcggac ggggagctga acgtggacag cctcatcacc cggcttgtct gcctatagca    180

gccattgtgg atgagaagat cttctgttgt catggaggat tgtcaccaga cctgcaatct    240

atggagcaga ttcggagaat tatgagacct actgatgtcc ctgatacagg tttgctctgt    300

gatttgctat ggtctgatcc agataaggat gtgcaaggct ggggagaaaa tgatcgtggt    360

gtttccttta cttttggagc tgatgtagtc agtaaatttc tgaatcgtca tgatttagat    420

ttgatttgtc gagctcatca ggtggtggaa gatggatatg aattttttgc taaacgacag    480

ttggtaacct tattttcagc cccaaattac tgtggcgagt ttgataatgc tggtggaatg    540

atgagtgtgg atgaaacttt gatgtgttca tttcagatat tgaaaccatc tgaaaagaaa    600

gctaaatacc agtatggtgg actgaattct ggacgtcctg tcactccacc tcgaacagct    660

aatccgccga agaaaaggtg aagaaaggaa ttctgtaaag aaaccatcag atttgttaag    720

gacatacttc ataatatata agtgtgcact gtaaaaccat ccagccattt gacacccttt    780

atgatgtcac acctttaact taaggagacg ggtaaaggat cttaaatttt tttctaatag    840

aaagatgtgc tacactgtat tgtaataagt atactctgtt atagtcaaca aagttaaatc    900

caaattcaaa attatccatt aaagttacat cttcatgtat cacaattttt aaagttgaaa    960

agcatcccag ttaaactaga tgtgatagtt aaaccagatg aaagcatgat gatccatctg   1020

tgtaatgtgg ttttagtgtt gcttggttgt ttaattattt tgagcttgtt ttgtttttgt   1080

ttgttttcac tagaataatg gcaaatactt ctaatttttt tccctaaaca tttttaaaag   1140

tgaaatatgg gaagagcttt acagacattc accaactatt attttccctt gtttatctac   1200

ttagatatct gtttaatctt actaagaaaa ctttcgcctc attacattaa aaaggaattt   1260

tagagattga ttgttttaaa aaaaaatacg cacattgtcc aatccagtga ttttaatcat   1320

acagtttgac tgggcaaact ttacagctga tagtgaatat tttgctttat acaggaattg   1380

acactgattt ggatttgtgc actctaattt ttaacttatt gatgctctat tgtgcagtag   1440

catttcattt aagataaggc tcatatagta ttacccaact agttggtaat gtgattatgt   1500

ggtaccttgg ctttaggttt tcattcgcac ggaacacctt ttggcatgct taacttcctg   1560

gtaacacctt cacctgcatt ggttttcttt ttcttttttc tttctttttt tttttttttt   1620

tttttttgag ttgttgtttg tttttagatc cacagtacat gagaatcctt ttttgacaag   1680

ccttggaaag ctgacactgt ctctttttcc tccctctata cgaaggatgt atttaaatga   1740

atgctggtca gtgggacatt ttgtcaacta tgggtattgg gtgcttaact gtctaatatt   1800

gccatgtgaa tgttgtatac gattgtaagg cttatgtcac taaagatttt tattctgatt   1860

ttttcataat caaaggtcat atgatactgt atagacaagc tttgtagtga agtatagtag   1920

caataatttc tgtacctgat caagtttatt gcagcctttc ttttcctatt tctttttttt   1980

aagggttagt attaacaaat ggcaatgagt agaaaagtta acatgaagat tttagaagga   2040

gagaacttac aggacacaga tttgtgattc tttgactgtg acactattgg atgtgattct   2100

aaaagctttt attgagcatt gtcaaatttg taagcttcat agggatggac atcatatcta   2160

taatgccctt ctatatgtgc taccatagat gtgacatttt tgaccttaat atcgtctttg   2220

aaaatgttaa attgagaaac ctgttaactt acattttatg aattggcaca ttgtattact   2280

tactgcaaga gatatttcat tttcagcaca gtgcaaaagt tctttaaaat gcatatgtct   2340

ttttttctaa ttccgttttg ttttaaagca cattttaaat gtagttttct catttagtaa   2400

aagttgtcta attgatatga agcctgactg attttttttt tccttacagt gagacattta   2460

agcacacatt ttattcacat agatactatg tccttgacat attgaaatga ttcttttctg   2520

aaagtattca tgatctgcat atgatgtatt aggttaggtc acaaaggttt tatctgaggt   2580

gatttaaata acttcctgat tggagtgtgt aagctgagcg atttctaata aaattttagt   2640

tgtacacttt tagtagtcat agtgaagcag gtctagaaaa taagcctttg gcagggaaaa   2700

agggcaatgt tgattaatct cagtattaaa ccacattaat ctgtatccca ttgtctggct   2760

tttgtaaatt catccaggtc aagactaagt atgttggtta ataggaatcc tttttttttt   2820

ttttaaagac taaatgtgaa aaaataatca ctacttaagc taattaatat tggtcattaa   2880

atttaaagga tggaaattta tcatgtttaa aaattattca agcactctta aaaccactta   2940

aacagcctcc agtcataaaa atgtgttctt tacaaatatt tgcttggcaa cacgacttga   3000

aataaataaa actttgtttc ttaggagaaa atgattctgt aattccagtg tcactaattt   3060

atattgttct ttcctctgat ttttttcagg ttagtgattt ttttgtatac aatttaatcc   3120

aaatgttatg acattcagaa atcatgaaac acagtagata tctgttataa tgtggtgtat   3180

cacatggatt ataaagcaaa gttatggtcg atttctattc ttgaaagaat caactacagt   3240

gaatcctttg catttgaagc cttaacatgc attgctttaa ttttgcccag ggacaaattt   3300

taataatcag caagactggt ttgtgcaaag cgttgagtca tcaggtattt agagcctagc   3360

cagctaccca gtatccatgc tgccatatcc cttcattgta aaaagtacct aaacattcgt   3420

gaaatgattt tttttagctg aaaaatgctg gcaagaagaa ttttaaagct taaaataggt   3480

ggtaaatttg aagtatgagt gtgttcacga gaaacatagg cttttcaaaa aaatttttat   3540

tcaaggcaaa gcaaggaaca tcttgagata tgtctcaaga atataaagat gtattatttt   3600

aagccaagga gctgaaatat atctcagttt ataaattcag gtatattctt tttgtctcca   3660

tggcaaccat aacttttgaa ccaaaaaaaa ttgtttttac atctttatgc tgaaaatgtg   3720

tttagattag gaatatggtc gggctgaatt tgctgttgct ccctaaccaa atccacctct   3780

tgttttcctt gtgagtccat ggctaaatca aagctgcccc tgagaagaga cttaatccaa   3840

gcctgattgt actagtggca tcacttagaa gtaggctttc cctcttccta gtagatctca   3900

atgttttata attccttaaa acagctgaaa attgggacaa catactttac gcaatgaaca   3960

gtagttaaat aggaaataaa ctagttccat ataagtatac acctagagtt ttaattacct   4020

ttataatgtt tcttaaaagt gaaacttaga tacaattgtg attggatact tagatactaa   4080

gtgaaactta gtgtaacaat tttgatctgt taaattggat tttacatgta catttgaatg   4140

ccagaatttc taaataaatc ccctggttag gaaattttaa aagtcaaagc ttgttttctt   4200

caaccactac cttctacatt ggttgactta gaccgtaagc tttttaagtt tctcattgta   4260

atttaccttc tcatgcagat tgctgatgtt ttattaaacc ttatttttac aaaaatgacc   4320

at                                                                  4322


<210>  7672
<211>  146
<212>  PRT
<213>  Homosapiens

<400>  7672

Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr Asp Val Pro Asp Thr 
1               5                   10                  15      


Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro Asp Lys Asp Val Gln 
            20                  25                  30          


Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe Thr Phe Gly Ala Asp 
        35                  40                  45              


Val Val Ser Lys Phe Leu Asn Arg His Asp Leu Asp Leu Ile Cys Arg 
    50                  55                  60                  


Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe Phe Ala Lys Arg Gln 
65                  70                  75                  80  


Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys Gly Glu Phe Asp Asn 
                85                  90                  95      


Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu Met Cys Ser Phe Gln 
            100                 105                 110         


Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr Gln Tyr Gly Gly Leu 
        115                 120                 125             


Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr Ala Asn Pro Pro Lys 
    130                 135                 140                 


Lys Arg 
145     


<210>  7673
<211>  1964
<212>  DNA
<213>  Homosapiens

<400>  7673
ctgcctatag cagccattgt ggatgagaag atcttctgtt gtcatggagg attgtcacca     60

gacctgcaat ctatggagca gattcggaga attatgagac ctactgatgt ccctgataca    120

gatattgaaa ccatctgaaa agaaagctaa ataccagtat ggtggactga attctggacg    180

tcctgtcact ccacctcgaa cagctaatcc gccgaagaaa aggtgaagaa aggaattctg    240

taaagaaacc atcagatttg ttaaggacat acttcataat atataagtgt gcactgtaaa    300

accatccagc catttgacac cctttatgat gtcacacctt taacttaagg agacgggtaa    360

aggatcttaa atttttttct aatagaaaga tgtgctacac tgtattgtaa taagtatact    420

ctgttatagt caacaaagtt aaatccaaat tcaaaattat ccattaaagt tacatcttca    480

tgtatcacaa tttttaaagt tgaaaagcat cccagttaaa ctagatgtga tagttaaacc    540

agatgaaagc atgatgatcc atctgtgtaa tgtggtttta gtgttgcttg gttgtttaat    600

tattttgagc ttgttttgtt tttgtttgtt ttcactagaa taatggcaaa tacttctaat    660

ttttttccct aaacattttt aaaagtgaaa tatgggaaga gctttacaga cattcaccaa    720

ctattatttt cccttgttta tctacttaga tatctgttta atcttactaa gaaaactttc    780

gcctcattac attaaaaagg aattttagag attgattgtt ttaaaaaaaa atacgcacat    840

tgtccaatcc agtgatttta atcatacagt ttgactgggc aaactttaca gctgatagtg    900

aatattttgc tttatacagg aattgacact gatttggatt tgtgcactct aatttttaac    960

ttattgatgc tctattgtgc agtagcattt catttaagat aaggctcata tagtattacc   1020

caactagttg gtaatgtgat tatgtggtac cttggcttta ggttttcatt cgcacggaac   1080

accttttggc atgcttaact tcctggtaac accttcacct gcattggttt tctttttctt   1140

ttttctttct tttttttttt tttttttttt ttgagttgtt gtttgttttt agatccacag   1200

tacatgagaa tccttttttg acaagccttg gaaagctgac actgtctctt tttcctccct   1260

ctatacgaag gatgtattta aatgaatgct ggtcagtggg acattttgtc aactatgggt   1320

attgggtgct taactgtcta atattgccat gtgaatgttg tatacgattg taaggcttat   1380

gtcactaaag atttttattc tgattttttc ataatcaaag gtcatatgat actgtataga   1440

caagctttgt agtgaagtat agtagcaata atttctgtac ctgatcaagt ttattgcagc   1500

ctttcttttc ctatttcttt tttttaaggg ttagtattaa caaatggcaa tgagtagaaa   1560

agttaacatg aagattttag aaggagagaa cttacaggac acagatttgt gattctttga   1620

ctgtgacact attggatgtg attctaaaag cttttattga gcattgtcaa atttgtaagc   1680

ttcataggga tggacatcat atctataatg cccttctata tgtgctacca tagatgtgac   1740

atttttgacc ttaatatcgt ctttgaaaat gttaaattga gaaacctgtt aacttacatt   1800

ttatgaattg gcacattgta ttacttactg caagagatat ttcattttca gcacagtgca   1860

aaagttcttt aaaatgcata tgtctttttt tctaattccg ttttgtttta aagcacattt   1920

taaatgtagt tttctcattt agtaaaagtt gtctaattga tatg                    1964


<210>  7674
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  7674

Met Ser Leu Ile Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
1               5                   10                  15      


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
            20                  25                  30          


Ala Asn Pro Pro Lys Lys Arg 
        35                  


<210>  7675
<211>  2585
<212>  DNA
<213>  Homosapiens

<400>  7675
ctgcctatag cagccattgt ggatgagaag atcttctgtt gtcatggagg attgtcacca     60

gacctgcaat ctatggagca gattcggaga attatgagac ctactgatgt ccctgataca    120

gatattgaaa ccatctgaaa agaaagctaa ataccagtat ggtggactga attctggacg    180

tcctgtcact ccacctcgaa cagctaatcc gccgaagaaa aggtgaagaa aggaattctg    240

taaagaaacc atcagatttg ttaaggacat acttcataat atataagtgt gcactgtaaa    300

accatccagc catttgacac cctttatgat gtcacacctt taacttaagg agacgggtaa    360

aggatcttaa atttttttct aatagaaaga tgtgctacac tgtattgtaa taagtatact    420

ctgttatagt caacaaagtt aaatccaaat tcaaaattat ccattaaagt tacatcttca    480

tgtatcacaa tttttaaagt tgaaaagcat cccagttaaa ctagatgtga tagttaaacc    540

agatgaaagc atgatgatcc atctgtgtaa tgtggtttta gtgttgcttg gttgtttaat    600

tattttgagc ttgttttgtt tttgtttgtt ttcactagaa taatggcaaa tacttctaat    660

ttttttccct aaacattttt aaaagtgaaa tatgggaaga gctttacaga cattcaccaa    720

ctattatttt cccttgttta tctacttaga tatctgttta atcttactaa gaaaactttc    780

gcctcattac attaaaaagg aattttagag attgattgtt ttaaaaaaaa atacgcacat    840

tgtccaatcc agtgatttta atcatacagt ttgactgggc aaactttaca gctgatagtg    900

aatattttgc tttatacagg aattgacact gatttggatt tgtgcactct aatttttaac    960

ttattgatgc tctattgtgc agtagcattt catttaagat aaggctcata tagtattacc   1020

caactagttg gtaatgtgat tatgtggtac cttggcttta ggttttcatt cgcacggaac   1080

accttttggc atgcttaact tcctggtaac accttcacct gcattggttt tctttttctt   1140

ttttctttct tttttttttt tttttttttt ttgagttgtt gtttgttttt agatccacag   1200

tacatgagaa tccttttttg acaagccttg gaaagctgac actgtctctt tttcctccct   1260

ctatacgaag gatgtattta aatgaatgct ggtcagtggg acattttgtc aactatgggt   1320

attgggtgct taactgtcta atattgccat gtgaatgttg tatacgattg taaggcttat   1380

gtcactaaag atttttattc tgattttttc ataatcaaag gtcatatgat actgtataga   1440

caagctttgt agtgaagtat agtagcaata atttctgtac ctgatcaagt ttattgcagc   1500

ctttcttttc ctatttcttt tttttaaggg ttagtattaa caaatggcaa tgagtagaaa   1560

agttaacatg aagattttag aaggagagaa cttacaggac acagatttgt gattctttga   1620

ctgtgacact attggatgtg attctaaaag cttttattga gcattgtcaa atttgtaagc   1680

ttcataggga tggacatcat atctataatg cccttctata tgtgctacca tagatgtgac   1740

atttttgacc ttaatatcgt ctttgaaaat gttaaattga gaaacctgtt aacttacatt   1800

ttatgaattg gcacattgta ttacttactg caagagatat ttcattttca gcacagtgca   1860

aaagttcttt aaaatgcata tgtctttttt tctaattccg ttttgtttta aagcacattt   1920

taaatgtagt tttctcattt agtaaaagtt gtctaattga tatgaagcct gactgatttt   1980

ttttttcctt acagtgagac atttaagcac acattttatt cacatagata ctatgtcctt   2040

gacatattga aatgattctt ttctgaaagt attcatgatc tgcatatgat gtattaggtt   2100

aggtcacaaa ggttttatct gaggtgattt aaataacttc ctgattggag tgtgtaagct   2160

gagcgatttc taataaaatt ttagttgtac acttttagta gtcatagtga agcaggtcta   2220

gaaaataagc ctttggcagg gaaaaagggc aatgttgatt aatctcagta ttaaaccaca   2280

ttaatctgta tcccattgtc tggcttttgt aaattcatcc aggtcaagac taagtatgtt   2340

ggttaatagg aatccttttt ttttttttta aagactaaat gtgaaaaaat aatcactact   2400

taagctaatt aatattggtc attaaattta aaggatggaa atttatcatg tttaaaaatt   2460

attcaagcac tcttaaaacc acttaaacag cctccagtca taaaaatgtg ttctttacaa   2520

atatttgctt ggcaacacga cttgaaataa ataaaacttt gtttcttagg agaaaatgat   2580

tctgt                                                               2585


<210>  7676
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  7676

Met Ser Leu Ile Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
1               5                   10                  15      


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
            20                  25                  30          


Ala Asn Pro Pro Lys Lys Arg 
        35                  


<210>  7677
<211>  3723
<212>  DNA
<213>  Homosapiens

<400>  7677
ctgcctatag cagccattgt ggatgagaag atcttctgtt gtcatggagg attgtcacca     60

gacctgcaat ctatggagca gattcggaga attatgagac ctactgatgt ccctgataca    120

gatattgaaa ccatctgaaa agaaagctaa ataccagtat ggtggactga attctggacg    180

tcctgtcact ccacctcgaa cagctaatcc gccgaagaaa aggtgaagaa aggaattctg    240

taaagaaacc atcagatttg ttaaggacat acttcataat atataagtgt gcactgtaaa    300

accatccagc catttgacac cctttatgat gtcacacctt taacttaagg agacgggtaa    360

aggatcttaa atttttttct aatagaaaga tgtgctacac tgtattgtaa taagtatact    420

ctgttatagt caacaaagtt aaatccaaat tcaaaattat ccattaaagt tacatcttca    480

tgtatcacaa tttttaaagt tgaaaagcat cccagttaaa ctagatgtga tagttaaacc    540

agatgaaagc atgatgatcc atctgtgtaa tgtggtttta gtgttgcttg gttgtttaat    600

tattttgagc ttgttttgtt tttgtttgtt ttcactagaa taatggcaaa tacttctaat    660

ttttttccct aaacattttt aaaagtgaaa tatgggaaga gctttacaga cattcaccaa    720

ctattatttt cccttgttta tctacttaga tatctgttta atcttactaa gaaaactttc    780

gcctcattac attaaaaagg aattttagag attgattgtt ttaaaaaaaa atacgcacat    840

tgtccaatcc agtgatttta atcatacagt ttgactgggc aaactttaca gctgatagtg    900

aatattttgc tttatacagg aattgacact gatttggatt tgtgcactct aatttttaac    960

ttattgatgc tctattgtgc agtagcattt catttaagat aaggctcata tagtattacc   1020

caactagttg gtaatgtgat tatgtggtac cttggcttta ggttttcatt cgcacggaac   1080

accttttggc atgcttaact tcctggtaac accttcacct gcattggttt tctttttctt   1140

ttttctttct tttttttttt tttttttttt ttgagttgtt gtttgttttt agatccacag   1200

tacatgagaa tccttttttg acaagccttg gaaagctgac actgtctctt tttcctccct   1260

ctatacgaag gatgtattta aatgaatgct ggtcagtggg acattttgtc aactatgggt   1320

attgggtgct taactgtcta atattgccat gtgaatgttg tatacgattg taaggcttat   1380

gtcactaaag atttttattc tgattttttc ataatcaaag gtcatatgat actgtataga   1440

caagctttgt agtgaagtat agtagcaata atttctgtac ctgatcaagt ttattgcagc   1500

ctttcttttc ctatttcttt tttttaaggg ttagtattaa caaatggcaa tgagtagaaa   1560

agttaacatg aagattttag aaggagagaa cttacaggac acagatttgt gattctttga   1620

ctgtgacact attggatgtg attctaaaag cttttattga gcattgtcaa atttgtaagc   1680

ttcataggga tggacatcat atctataatg cccttctata tgtgctacca tagatgtgac   1740

atttttgacc ttaatatcgt ctttgaaaat gttaaattga gaaacctgtt aacttacatt   1800

ttatgaattg gcacattgta ttacttactg caagagatat ttcattttca gcacagtgca   1860

aaagttcttt aaaatgcata tgtctttttt tctaattccg ttttgtttta aagcacattt   1920

taaatgtagt tttctcattt agtaaaagtt gtctaattga tatgaagcct gactgatttt   1980

ttttttcctt acagtgagac atttaagcac acattttatt cacatagata ctatgtcctt   2040

gacatattga aatgattctt ttctgaaagt attcatgatc tgcatatgat gtattaggtt   2100

aggtcacaaa ggttttatct gaggtgattt aaataacttc ctgattggag tgtgtaagct   2160

gagcgatttc taataaaatt ttagttgtac acttttagta gtcatagtga agcaggtcta   2220

gaaaataagc ctttggcagg gaaaaagggc aatgttgatt aatctcagta ttaaaccaca   2280

ttaatctgta tcccattgtc tggcttttgt aaattcatcc aggtcaagac taagtatgtt   2340

ggttaatagg aatccttttt ttttttttta aagactaaat gtgaaaaaat aatcactact   2400

taagctaatt aatattggtc attaaattta aaggatggaa atttatcatg tttaaaaatt   2460

attcaagcac tcttaaaacc acttaaacag cctccagtca taaaaatgtg ttctttacaa   2520

atatttgctt ggcaacacga cttgaaataa ataaaacttt gtttcttagg agaaaatgat   2580

tctgtaattc cagtgtcact aatttatatt gttctttcct ctgatttttt tcaggttagt   2640

gatttttttg tatacaattt aatccaaatg ttatgacatt cagaaatcat gaaacacagt   2700

agatatctgt tataatgtgg tgtatcacat ggattataaa gcaaagttat ggtcgatttc   2760

tattcttgaa agaatcaact acagtgaatc ctttgcattt gaagccttaa catgcattgc   2820

tttaattttg cccagggaca aattttaata atcagcaaga ctggtttgtg caaagcgttg   2880

agtcatcagg tatttagagc ctagccagct acccagtatc catgctgcca tatcccttca   2940

ttgtaaaaag tacctaaaca ttcgtgaaat gatttttttt agctgaaaaa tgctggcaag   3000

aagaatttta aagcttaaaa taggtggtaa atttgaagta tgagtgtgtt cacgagaaac   3060

ataggctttt caaaaaaatt tttattcaag gcaaagcaag gaacatcttg agatatgtct   3120

caagaatata aagatgtatt attttaagcc aaggagctga aatatatctc agtttataaa   3180

ttcaggtata ttctttttgt ctccatggca accataactt ttgaaccaaa aaaaattgtt   3240

tttacatctt tatgctgaaa atgtgtttag attaggaata tggtcgggct gaatttgctg   3300

ttgctcccta accaaatcca cctcttgttt tccttgtgag tccatggcta aatcaaagct   3360

gcccctgaga agagacttaa tccaagcctg attgtactag tggcatcact tagaagtagg   3420

ctttccctct tcctagtaga tctcaatgtt ttataattcc ttaaaacagc tgaaaattgg   3480

gacaacatac tttacgcaat gaacagtagt taaataggaa ataaactagt tccatataag   3540

tatacaccta gagttttaat tacctttata atgtttctta aaagtgaaac ttagatacaa   3600

ttgtgattgg atacttagat actaagtgaa acttagtgta acaattttga tctgttaaat   3660

tggattttac atgtacattt gaatgccaga atttctaaat aaatcccctg gttaggaaat   3720

ttt                                                                 3723


<210>  7678
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  7678

Met Ser Leu Ile Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
1               5                   10                  15      


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
            20                  25                  30          


Ala Asn Pro Pro Lys Lys Arg 
        35                  


<210>  7679
<211>  2389
<212>  DNA
<213>  Homosapiens

<400>  7679
caagaattct aggcttcata taatatattt gctttagtat taacaataaa ataataaaat     60

aatctttggc agattggtag gttactctgt atggcttatg aaataagctt gaagtttttt    120

gaaagtttat ttgaaaaatt aatgtatatg tctaacacct agctagtaga tagtgtatga    180

tctgaccatc ttgaagagtt aaaaacctgt tgctaagata catttatgaa acagataatt    240

gagtaataaa aggtatttaa tatgtcagaa cttattaaga cactatgaga agtcaggagg    300

aggaaagact gggtacatgt gtgtatggag gcatgggttt tagaggataa ataggctttg    360

gagaagttaa aaggacttga gacactcttt gttgtctagt ttagggaatg tgtaagaact    420

ggcctgacta gaaggtcaag tacatgctgg gaaatgatgg aatcagatta tggagatttg    480

actattgagc aacggagttt gttgagtgat ttaataaccg tattgggttt ttgtacaggg    540

aagtaattta atggaaatag tgtaagaaaa ttagtttttc atcaatatac gggaagaatt    600

aaagtggaaa aacgctgaaa agatagatgc acttgcctag gcccgaggat tgtcaccaga    660

cctgcaatct atggagcaga ttcggagaat tatgagacct actgatgtcc ctgatacagg    720

tttgctctgt gatttgctat ggtctgatcc agataaggat gtgcaaggct ggggagaaaa    780

tgatcgtggt gtttccttta cttttggagc tgatgtagtc agtaaatttc tgaatcgtca    840

tgatttagat ttgatttgtc gagctcatca ggtggtggaa gatggatatg aattttttgc    900

taaacgacag ttggtaacct tattttcagc cccaaattac tgtggcgagt ttgataatgc    960

tggtggaatg atgagtgtgg atgaaacttt gatgtgttca tttcagatat tgaaaccatc   1020

tgaaaagaaa gctaaatacc agtatggtgg actgaattct ggacgtcctg tcactccacc   1080

tcgaacagct aatccgccga agaaaagtcc ttccttcaga agggaaattt ctgagggtca   1140

ggaaggggaa tctgtacctc actccttgaa caccaaggaa ggaatattgg gaaaccaaaa   1200

tgaggcacaa tcagatgtgt tgtgagacac cacctactgt cactgtttat gtaaaatcag   1260

ggtcaaatag atcacatcag cctaaaaagc ccattactct gaagcgtcct atttgtaaag   1320

ataattggca agcatttgaa aaaaatacac ataataacaa caaatctaaa cgccccaaag   1380

gaccttgtct ggttatacag cgtcaggata tgactgcttt ctttaaatta tttgatgacg   1440

atttaattca agatttcttg tggatggact gctgctgtaa aattgcagac aagtatcttt   1500

tggctatgac ctttgtttat ttcaagaggg ctaaatttac tataagtgag cataccagga   1560

taaatttctt tattgctctg tatctggcta atacagttga agaagatgaa gaagaaacca   1620

agtacgaaat ttttccatgg gctttaggga aaaactggag aaaattgttc cctaatttct   1680

taaagttaag ggaccagctc tgggatagaa ttgactatag ggctattgta agcaggcgat   1740

gttgtgagga ggttatggcc attgcaccaa cccattatat ctggcaaaga gaacgttctg   1800

ttcatcacag tggagctgtc agaaactaca acagagatga agttcagctg ccccggggac   1860

ctagtgccac accagtagat tgttcactct gtggtaaaaa aagaagatat gttagactgg   1920

gattgtcttc atcatcatct ttatccagtc atacagcagg ggtgacagaa aaacattctc   1980

aggactcata caactcactg tcaatggaca taataggtga tccttctcaa gcttatactg   2040

gttctgaagg tatgatttag taatatgcca gaattagatt tatgcatgtt gtttactgag   2100

ctctagtcag tcctttctgg cggggataca taataattta tatactccaa caatatgagt   2160

taaattaatc ttgaaacttt ctcccctttc agttactttt tgtcttgtgt ccatatttgt   2220

tttgtggtga cccacctaaa cagattttta atgtgaccta tgttaagttg aaaactaatg   2280

caccataagc ctcagtattt taagagcctg aatcattttt ttgaaatgtt tattttattc   2340

aaaagggttt caagaagaaa ataaatttac ttgtaatctc accttccaa               2389


<210>  7680
<211>  286
<212>  PRT
<213>  Homosapiens

<400>  7680

Met Arg His Asn Gln Met Cys Cys Glu Thr Pro Pro Thr Val Thr Val 
1               5                   10                  15      


Tyr Val Lys Ser Gly Ser Asn Arg Ser His Gln Pro Lys Lys Pro Ile 
            20                  25                  30          


Thr Leu Lys Arg Pro Ile Cys Lys Asp Asn Trp Gln Ala Phe Glu Lys 
        35                  40                  45              


Asn Thr His Asn Asn Asn Lys Ser Lys Arg Pro Lys Gly Pro Cys Leu 
    50                  55                  60                  


Val Ile Gln Arg Gln Asp Met Thr Ala Phe Phe Lys Leu Phe Asp Asp 
65                  70                  75                  80  


Asp Leu Ile Gln Asp Phe Leu Trp Met Asp Cys Cys Cys Lys Ile Ala 
                85                  90                  95      


Asp Lys Tyr Leu Leu Ala Met Thr Phe Val Tyr Phe Lys Arg Ala Lys 
            100                 105                 110         


Phe Thr Ile Ser Glu His Thr Arg Ile Asn Phe Phe Ile Ala Leu Tyr 
        115                 120                 125             


Leu Ala Asn Thr Val Glu Glu Asp Glu Glu Glu Thr Lys Tyr Glu Ile 
    130                 135                 140                 


Phe Pro Trp Ala Leu Gly Lys Asn Trp Arg Lys Leu Phe Pro Asn Phe 
145                 150                 155                 160 


Leu Lys Leu Arg Asp Gln Leu Trp Asp Arg Ile Asp Tyr Arg Ala Ile 
                165                 170                 175     


Val Ser Arg Arg Cys Cys Glu Glu Val Met Ala Ile Ala Pro Thr His 
            180                 185                 190         


Tyr Ile Trp Gln Arg Glu Arg Ser Val His His Ser Gly Ala Val Arg 
        195                 200                 205             


Asn Tyr Asn Arg Asp Glu Val Gln Leu Pro Arg Gly Pro Ser Ala Thr 
    210                 215                 220                 


Pro Val Asp Cys Ser Leu Cys Gly Lys Lys Arg Arg Tyr Val Arg Leu 
225                 230                 235                 240 


Gly Leu Ser Ser Ser Ser Ser Leu Ser Ser His Thr Ala Gly Val Thr 
                245                 250                 255     


Glu Lys His Ser Gln Asp Ser Tyr Asn Ser Leu Ser Met Asp Ile Ile 
            260                 265                 270         


Gly Asp Pro Ser Gln Ala Tyr Thr Gly Ser Glu Gly Met Ile 
        275                 280                 285     


<210>  7681
<211>  640
<212>  DNA
<213>  Homosapiens

<400>  7681
actatgatgt ttatggatta tttaaaattc ttaaaactga cttaactctt taaaaattat     60

cttcttgtgc tgggattata ggcacgagcc acctcgcccg gcctgacaaa tagtttttta    120

aatcagtaaa actgtgttta tgattttgat aaatatgcct tctattaaat aacaaggcag    180

aattgctaag tttcctaact aaaatgaccc ctgataatca gtttttttca gccatagatc    240

ttcattcact ggtcttttca aaaataaatg atgattttta aaaatcaggt ttctgaacta    300

cgctagtttg catggtcttt tgttttccag aaactgccaa aatccttcta ttgtgcttat    360

tttcaaataa ttgtctctaa aattctagaa atattccctt taaaaaagaa aatttgaaag    420

aatgaacaag taagcaaact aaaaaaccaa gaactaaaaa catggagtcc atgaccagcc    480

tgggcaacac agtgaaacac gaaaccctgt ctctacaaaa aaatacaaaa aactggctgg    540

gcaccgtggc tcacgcctga agtcccagca ttttgggagg ctgaggcgag tggatcacct    600

gaggtcagga gttcgaggcc agcctgaaaa acatggagaa                          640


<210>  7682
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  7682

Met Glu Ser Met Thr Ser Leu Gly Asn Thr Val Lys His Glu Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Asn Thr Lys Asn Trp Leu Gly Thr Val Ala His Ala 
            20                  25                  30          


<210>  7683
<211>  6127
<212>  DNA
<213>  Homosapiens

<400>  7683
atggcggggg cctggctcag gtgggggctc ctgctctggg cagggctcct cgcgtcctcg     60

gcgcacggcc ggctgcggag gatcacctac gtggtgcacc cgggccccgg cctggcagcc    120

ggcgccttgc ccctgagcgg gcccccgcgt tcgcggacat tcaacgtcgc gctcaacgcc    180

aggtacagcc gcagctcggc ggctgccggc gcccccagcc gtgcctcccc cggggtcccc    240

tcggagagga cccggcgcac gagcaagccg ggcggcgcgg ccctgcaggg gctcagaccg    300

ccgccgccgc cgccgccgga gcctgcgcgt cccgcggtcc ccggcgggca gctccacccc    360

aatcccggcg gccacccggc agccgccccg ttcaccaaac aaggcaggca agttgtgcgc    420

tccaaggtgc cgcaggagac ccagagcggc ggaggctcta ggctgcaggt tcaccagaag    480

cagcagctgc agggggtcaa tgtctgtgga gggcggtgct gtcatggctg gagtaaggcc    540

cctggctccc agaggtgcac caaacctagc tgtgttccgc catgtcagaa tggagggatg    600

tgtctccggc cacaactctg tgtgtgtaaa ccagggacca agggcaaagc ctgtgaaaca    660

atagctgccc aggacacctc gtcaccagtc tttggagggc agagtcctgg ggctgcttcc    720

tcgtggggcc ctcctgagca agcagcaaag catacttcat ctaagaaggc agacactcta    780

ccaagagtca gccctgtggc ccagatgacc ttaaccctca agccgaagcc ttcagtggga    840

ctcccccagc agatacattc tcaagtgact cctctttctt cccagagtgt ggtgattcac    900

catggccaga cccaggaata cgtgctcaag cccaagtact ttccagccca gaaggggatt    960

tcaggagagc agtccactga aggttctttc cctttaagat atgtgcagga tcaagttgcg   1020

gcaccttttc agctgagtaa ccacactggc cgcatcaagg tggtctttac tccgagcatc   1080

tgtaaagtga cctgcaccaa gggcagctgt cagaacagct gtgagaaggg gaacaccacc   1140

actctcatta gtgagaatgg tcatgctgcc gacaccctga cggccacgaa cttccgagtg   1200

gtaatttgcc atcttccatg tatgaatggt ggccagtgca gttcaaggga caaatgtcag   1260

tgccctccaa atttcacagg aaaactttgt cagatcccag tccatggtgc cagcgtgcct   1320

aaactttatc agcattccca gcagccaggc aaggcgttgg ggacgcatgt catccattca   1380

acacatacct tgcctctgac cgtgactagc cagcaaggag tcaaagtgaa atttcctcct   1440

aacatagtca atatccatgt gaaacatcct cctgaagctt ccgtccagat acatcaggtt   1500

tcaagaattg atggcccaac aggccagaag acaaaagaag ctcaaccagg ccaatcccaa   1560

gtctcgtacc aagggcttcc tgtccagaag acccagacca tacattccac atactcccac   1620

cagcaggtca ttcctcacgt ctaccccgtg gctgctaaga cacagcttgg ccggtgcttc   1680

caggaaacca ttgggtcaca gtgtggcaaa gcgctccctg gcctttcaaa gcaagaggac   1740

tgctgtggaa ctgtgggtac ctcctggggc tttaacaaat gccagaaatg ccccaagaaa   1800

ccatcttatc atggatacaa ccaaatgatg gaatgcctac cgggttataa gcgggttaac   1860

aacacctttt gccaagatat taatgaatgt cagctacaag gtgtatgccc taatggtgag   1920

tgtttgaata ccatgggcag ctatcgatgt acctgcaaaa taggatttgg gccggatcct   1980

accttttcaa gttgtgttcc tgatccccct gtgatctcgg aagagaaagg gccctgttac   2040

cgacttgtca gttctggaag acagtgtatg caccctctgt ctgttcacct caccaagcag   2100

ctctgctgtt gtagtgtggg caaggcctgg ggcccacact gtgagaaatg tccccttcca   2160

ggcacagctg cttttaagga aatctgtcct ggtggaatgg gttatacggt ttctggcgtt   2220

catagacgca ggccaatcca tcaccatgta ggtaaaggac ctgtatttgt caagccaaag   2280

aacactcaac ctgttgctaa aagtactcat cctccacctc tcccagccaa ggaagagcca   2340

gtggaggccc tgaccttctc ccgggaacac gggccaggag tggcggagcc agaagtggca   2400

actgcacccc ctgaaaagga aataccttca ttggatcaag agaaaaccaa acttgagcct   2460

ggtcaacccc agctgtctcc aggcatttcc actattcatc tgcatccaca gtttccagta   2520

gtgattgaaa aaacatcacc tcctgtgcct gttgaagtag ctcctgaagc ttctacgtct   2580

agtgccagcc aagtgattgc tcctactcaa gtgacagaaa tcaatgaatg tactgtgaac   2640

cctgatatct gtggagcagg acactgcatt aacctaccag tgagatatac ctgtatatgc   2700

tacgagggct acaggttcag tgaacaacag aggaaatgtg tggatattga tgagtgtact   2760

caggtccaac acctctgctc ccagggccgc tgtgaaaaca ccgagggaag tttcttgtgc   2820

atttgcccag caggatttat ggccagtgag gagggtacta actgcataga tgttgacgaa   2880

tgcctgaggc cggacgtctg tggggagggg cactgtgtca atactgtggg ggccttccgg   2940

tgtgaatact gtgacagcgg gtaccgcatg actcagagag gccgttgtga ggatattgat   3000

gaatgtttga atccaagcac ttgtccagat gagcagtgtg tgaattctcc tggatcttac   3060

cagtgcgttc cctgcacaga aggattccga ggctggaatg gacagtgcct tgatgtggac   3120

gagtgcctgg aaccaaacgt ctgcgcaaat ggtgattgtt ccaaccttga aggctcctac   3180

atgtgttcat gccacaaagg ctatacccgg actccggacc acaagcactg tagagatatt   3240

gatgaatgtc agcaagggaa tctatgtgta aacgggcagt gcaaaaatac cgagggctcc   3300

ttcaggtgca cctgtggaca ggggtaccag ctgtcggcag ctaaagacca gtgtgaagac   3360

attgatgaat gccagcaccg tcatctctgt gctcatgggc agtgcaggaa cactgagggc   3420

tcttttcaat gtgtgtgtga ccagggttac agagcatctg ggcttggaga ccactgtgaa   3480

gatatcaatg aatgcttgga ggacaagagt gtttgccaga gaggagactg cattaatact   3540

gcagggtcct atgattgtac ttgtccggat ggatttcagc tagatgacaa taaaacatgt   3600

caagatatta atgaatgtga acatccaggg ctctgtggtc cgcaagggga gtgcctaaac   3660

acagagggtt ctttccattg tgtctgccag cagggtttct caatctctgc agatggccgt   3720

acgtgtgaag atattgatga atgtgtaaac aacactgttt gtgacagtca cgggttttgt   3780

gacaatacag ctggctcctt ccgctgcctc tgttatcagg gctttcaagc cccacaggat   3840

gggcaagggt gtgtggatgt gaatgaatgt gaactgctca gtggggtgtg tggtgaagcc   3900

ttctgtgaaa acgtggaagg gtccttcctg tgcgtgtgtg ctgatgaaaa ccaagagtac   3960

agccccatga ctgggcagtg ccgctcccgg acctccacag atttagatgt agatgtagat   4020

caacccaaag aagaaaagaa agaatgctac tataatctca atgacgccag tctctgtgat   4080

aatgtgttgg cccccaatgt cacgaaacaa gaatgctgct gtacatcagg cgtgggatgg   4140

ggagataact gcgaaatctt cccctgcccg gtcttgggaa ctgctgagtt cactgaaatg   4200

tgtcccaaag ggaaaggttt tgtgcctgct ggagaatcat cttctgaagc tggtggtgag   4260

aactataaag atgcagatga atgcctactt tttggacaag aaatctgcaa aaatggtttc   4320

tgtttgaaca ctcggcctgg gtatgaatgc tactgtaagc aagggacgta ctatgatcct   4380

gtgaaactgc agtgctttga tatggatgaa tgtcaagacc ccagtagttg tattgatggc   4440

cagtgtgtta atacagaggg ctcttacaac tgcttctgta ctcaccccat ggtcctggat   4500

gcgtcagaaa aaagatgtat acgaccggct gagtcaaacg aacaaataga agaaactgat   4560

gtctaccaag atttgtgctg ggaacatctg agtgatgaat acgtgtgtag ccggcctctt   4620

gtgggcaagc agacaacgta cactgagtgc tgctgtctgt atggagaggc ctggggcatg   4680

cagtgtgccc tctgccccct gaaggattca gatgactatg ctcagctgtg taacatcccc   4740

gtgacgggac gccggcagcc atatggacgg gacgccttgg ttgacttcag tgaacagtat   4800

actccagaag ccgatcccta cttcatccaa gaccgttttc taaatagctt tgaggagtta   4860

caggctgagg aatgcggcat cctcaatgga tgtgaaaatg gtcgctgtgt gagggtccag   4920

gaaggttaca cctgcgattg ctttgatggg tatcacttgg atacggccaa gatgacctgt   4980

gtcgatgtaa atgaatgcga tgagttgaac aaccggatgt ctctctgcaa gaatgccaag   5040

tgcattaaca ccgatggttc ctacaagtgt ttgtgtctgc caggctacgt gccttctgac   5100

aagccaaact actgcactcc gttgaatacc gccttgaatt tagagaaaga cagtgacctg   5160

gagtgaaaca gaatctacat aacctaagcc catatactct gcactgtgta aaggaaaagg   5220

gagaaatgta ttatacttga gacattgcac ctaccccgga aggctggaaa tacagaaaca   5280

gcatggaatt gcaagtcctc tgaagacaat gagaggattt aggatgagcc cgataggtgt   5340

ggcagaccaa atggacattt ctctaaaaaa ccagtatata tagtctgttc atatgtaaaa   5400

ttcaatggaa gagaggtgga acagtgctgt tattttaaac agaaggttgt attattatgt   5460

tgttttgttt ttttactatt gcttgattaa atttggcatt taaatagtgg tggaaatatt   5520

ttatataatt ttcatttttt ggttgtgcag ttccttggct actgtttttc ttttacttca   5580

gttttttaaa aatctcaaat gaaaaagtct tcgatacaat attgttaagc tgtattataa   5640

gtattgttac acagggttat gcaattcccg gcctggagca tttttgaaat tcaaattgtc   5700

tgtcctgtgg agcaggcagt gattttgttc caaaactttg tatacacatt tggagaaaag   5760

tactttatat tttcagtgtt ttgtctgatt ttaatgtccg ttcttagcca agctgctagc   5820

aggtgttaat tggatccctt tccttcactg aaatggaaga gtttataagc ttacgttagt   5880

attgtaatat gtaaagtaag cccaacaaaa atttttaaaa atttgatgat ccccaatata   5940

tctaccattg tatgttaaat aaatcaccat ttttgtagaa aaaattctac ctgagagtaa   6000

ttgtcaatga gtacatgtgt ataagttgta tcccactctc cccactttta tcttttccag   6060

tggtcttctg ttaatgtagt gtcttttaca agttaatcat taaatttgtt agatcttgtt   6120

atgggct                                                             6127


<210>  7684
<211>  1721
<212>  PRT
<213>  Homosapiens

<400>  7684

Met Ala Gly Ala Trp Leu Arg Trp Gly Leu Leu Leu Trp Ala Gly Leu 
1               5                   10                  15      


Leu Ala Ser Ser Ala His Gly Arg Leu Arg Arg Ile Thr Tyr Val Val 
            20                  25                  30          


His Pro Gly Pro Gly Leu Ala Ala Gly Ala Leu Pro Leu Ser Gly Pro 
        35                  40                  45              


Pro Arg Ser Arg Thr Phe Asn Val Ala Leu Asn Ala Arg Tyr Ser Arg 
    50                  55                  60                  


Ser Ser Ala Ala Ala Gly Ala Pro Ser Arg Ala Ser Pro Gly Val Pro 
65                  70                  75                  80  


Ser Glu Arg Thr Arg Arg Thr Ser Lys Pro Gly Gly Ala Ala Leu Gln 
                85                  90                  95      


Gly Leu Arg Pro Pro Pro Pro Pro Pro Pro Glu Pro Ala Arg Pro Ala 
            100                 105                 110         


Val Pro Gly Gly Gln Leu His Pro Asn Pro Gly Gly His Pro Ala Ala 
        115                 120                 125             


Ala Pro Phe Thr Lys Gln Gly Arg Gln Val Val Arg Ser Lys Val Pro 
    130                 135                 140                 


Gln Glu Thr Gln Ser Gly Gly Gly Ser Arg Leu Gln Val His Gln Lys 
145                 150                 155                 160 


Gln Gln Leu Gln Gly Val Asn Val Cys Gly Gly Arg Cys Cys His Gly 
                165                 170                 175     


Trp Ser Lys Ala Pro Gly Ser Gln Arg Cys Thr Lys Pro Ser Cys Val 
            180                 185                 190         


Pro Pro Cys Gln Asn Gly Gly Met Cys Leu Arg Pro Gln Leu Cys Val 
        195                 200                 205             


Cys Lys Pro Gly Thr Lys Gly Lys Ala Cys Glu Thr Ile Ala Ala Gln 
    210                 215                 220                 


Asp Thr Ser Ser Pro Val Phe Gly Gly Gln Ser Pro Gly Ala Ala Ser 
225                 230                 235                 240 


Ser Trp Gly Pro Pro Glu Gln Ala Ala Lys His Thr Ser Ser Lys Lys 
                245                 250                 255     


Ala Asp Thr Leu Pro Arg Val Ser Pro Val Ala Gln Met Thr Leu Thr 
            260                 265                 270         


Leu Lys Pro Lys Pro Ser Val Gly Leu Pro Gln Gln Ile His Ser Gln 
        275                 280                 285             


Val Thr Pro Leu Ser Ser Gln Ser Val Val Ile His His Gly Gln Thr 
    290                 295                 300                 


Gln Glu Tyr Val Leu Lys Pro Lys Tyr Phe Pro Ala Gln Lys Gly Ile 
305                 310                 315                 320 


Ser Gly Glu Gln Ser Thr Glu Gly Ser Phe Pro Leu Arg Tyr Val Gln 
                325                 330                 335     


Asp Gln Val Ala Ala Pro Phe Gln Leu Ser Asn His Thr Gly Arg Ile 
            340                 345                 350         


Lys Val Val Phe Thr Pro Ser Ile Cys Lys Val Thr Cys Thr Lys Gly 
        355                 360                 365             


Ser Cys Gln Asn Ser Cys Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser 
    370                 375                 380                 


Glu Asn Gly His Ala Ala Asp Thr Leu Thr Ala Thr Asn Phe Arg Val 
385                 390                 395                 400 


Val Ile Cys His Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser Arg 
                405                 410                 415     


Asp Lys Cys Gln Cys Pro Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile 
            420                 425                 430         


Pro Val His Gly Ala Ser Val Pro Lys Leu Tyr Gln His Ser Gln Gln 
        435                 440                 445             


Pro Gly Lys Ala Leu Gly Thr His Val Ile His Ser Thr His Thr Leu 
    450                 455                 460                 


Pro Leu Thr Val Thr Ser Gln Gln Gly Val Lys Val Lys Phe Pro Pro 
465                 470                 475                 480 


Asn Ile Val Asn Ile His Val Lys His Pro Pro Glu Ala Ser Val Gln 
                485                 490                 495     


Ile His Gln Val Ser Arg Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys 
            500                 505                 510         


Glu Ala Gln Pro Gly Gln Ser Gln Val Ser Tyr Gln Gly Leu Pro Val 
        515                 520                 525             


Gln Lys Thr Gln Thr Ile His Ser Thr Tyr Ser His Gln Gln Val Ile 
    530                 535                 540                 


Pro His Val Tyr Pro Val Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe 
545                 550                 555                 560 


Gln Glu Thr Ile Gly Ser Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser 
                565                 570                 575     


Lys Gln Glu Asp Cys Cys Gly Thr Val Gly Thr Ser Trp Gly Phe Asn 
            580                 585                 590         


Lys Cys Gln Lys Cys Pro Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln 
        595                 600                 605             


Met Met Glu Cys Leu Pro Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys 
    610                 615                 620                 


Gln Asp Ile Asn Glu Cys Gln Leu Gln Gly Val Cys Pro Asn Gly Glu 
625                 630                 635                 640 


Cys Leu Asn Thr Met Gly Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe 
                645                 650                 655     


Gly Pro Asp Pro Thr Phe Ser Ser Cys Val Pro Asp Pro Pro Val Ile 
            660                 665                 670         


Ser Glu Glu Lys Gly Pro Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln 
        675                 680                 685             


Cys Met His Pro Leu Ser Val His Leu Thr Lys Gln Leu Cys Cys Cys 
    690                 695                 700                 


Ser Val Gly Lys Ala Trp Gly Pro His Cys Glu Lys Cys Pro Leu Pro 
705                 710                 715                 720 


Gly Thr Ala Ala Phe Lys Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr 
                725                 730                 735     


Val Ser Gly Val His Arg Arg Arg Pro Ile His His His Val Gly Lys 
            740                 745                 750         


Gly Pro Val Phe Val Lys Pro Lys Asn Thr Gln Pro Val Ala Lys Ser 
        755                 760                 765             


Thr His Pro Pro Pro Leu Pro Ala Lys Glu Glu Pro Val Glu Ala Leu 
    770                 775                 780                 


Thr Phe Ser Arg Glu His Gly Pro Gly Val Ala Glu Pro Glu Val Ala 
785                 790                 795                 800 


Thr Ala Pro Pro Glu Lys Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr 
                805                 810                 815     


Lys Leu Glu Pro Gly Gln Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile 
            820                 825                 830         


His Leu His Pro Gln Phe Pro Val Val Ile Glu Lys Thr Ser Pro Pro 
        835                 840                 845             


Val Pro Val Glu Val Ala Pro Glu Ala Ser Thr Ser Ser Ala Ser Gln 
    850                 855                 860                 


Val Ile Ala Pro Thr Gln Val Thr Glu Ile Asn Glu Cys Thr Val Asn 
865                 870                 875                 880 


Pro Asp Ile Cys Gly Ala Gly His Cys Ile Asn Leu Pro Val Arg Tyr 
                885                 890                 895     


Thr Cys Ile Cys Tyr Glu Gly Tyr Arg Phe Ser Glu Gln Gln Arg Lys 
            900                 905                 910         


Cys Val Asp Ile Asp Glu Cys Thr Gln Val Gln His Leu Cys Ser Gln 
        915                 920                 925             


Gly Arg Cys Glu Asn Thr Glu Gly Ser Phe Leu Cys Ile Cys Pro Ala 
    930                 935                 940                 


Gly Phe Met Ala Ser Glu Glu Gly Thr Asn Cys Ile Asp Val Asp Glu 
945                 950                 955                 960 


Cys Leu Arg Pro Asp Val Cys Gly Glu Gly His Cys Val Asn Thr Val 
                965                 970                 975     


Gly Ala Phe Arg Cys Glu Tyr Cys Asp Ser Gly Tyr Arg Met Thr Gln 
            980                 985                 990         


Arg Gly Arg Cys Glu Asp Ile Asp  Glu Cys Leu Asn Pro  Ser Thr Cys 
        995                 1000                 1005             


Pro Asp  Glu Gln Cys Val Asn  Ser Pro Gly Ser Tyr  Gln Cys Val 
    1010                 1015                 1020             


Pro Cys  Thr Glu Gly Phe Arg  Gly Trp Asn Gly Gln  Cys Leu Asp 
    1025                 1030                 1035             


Val Asp  Glu Cys Leu Glu Pro  Asn Val Cys Ala Asn  Gly Asp Cys 
    1040                 1045                 1050             


Ser Asn  Leu Glu Gly Ser Tyr  Met Cys Ser Cys His  Lys Gly Tyr 
    1055                 1060                 1065             


Thr Arg  Thr Pro Asp His Lys  His Cys Arg Asp Ile  Asp Glu Cys 
    1070                 1075                 1080             


Gln Gln  Gly Asn Leu Cys Val  Asn Gly Gln Cys Lys  Asn Thr Glu 
    1085                 1090                 1095             


Gly Ser  Phe Arg Cys Thr Cys  Gly Gln Gly Tyr Gln  Leu Ser Ala 
    1100                 1105                 1110             


Ala Lys  Asp Gln Cys Glu Asp  Ile Asp Glu Cys Gln  His Arg His 
    1115                 1120                 1125             


Leu Cys  Ala His Gly Gln Cys  Arg Asn Thr Glu Gly  Ser Phe Gln 
    1130                 1135                 1140             


Cys Val  Cys Asp Gln Gly Tyr  Arg Ala Ser Gly Leu  Gly Asp His 
    1145                 1150                 1155             


Cys Glu  Asp Ile Asn Glu Cys  Leu Glu Asp Lys Ser  Val Cys Gln 
    1160                 1165                 1170             


Arg Gly  Asp Cys Ile Asn Thr  Ala Gly Ser Tyr Asp  Cys Thr Cys 
    1175                 1180                 1185             


Pro Asp  Gly Phe Gln Leu Asp  Asp Asn Lys Thr Cys  Gln Asp Ile 
    1190                 1195                 1200             


Asn Glu  Cys Glu His Pro Gly  Leu Cys Gly Pro Gln  Gly Glu Cys 
    1205                 1210                 1215             


Leu Asn  Thr Glu Gly Ser Phe  His Cys Val Cys Gln  Gln Gly Phe 
    1220                 1225                 1230             


Ser Ile  Ser Ala Asp Gly Arg  Thr Cys Glu Asp Ile  Asp Glu Cys 
    1235                 1240                 1245             


Val Asn  Asn Thr Val Cys Asp  Ser His Gly Phe Cys  Asp Asn Thr 
    1250                 1255                 1260             


Ala Gly  Ser Phe Arg Cys Leu  Cys Tyr Gln Gly Phe  Gln Ala Pro 
    1265                 1270                 1275             


Gln Asp  Gly Gln Gly Cys Val  Asp Val Asn Glu Cys  Glu Leu Leu 
    1280                 1285                 1290             


Ser Gly  Val Cys Gly Glu Ala  Phe Cys Glu Asn Val  Glu Gly Ser 
    1295                 1300                 1305             


Phe Leu  Cys Val Cys Ala Asp  Glu Asn Gln Glu Tyr  Ser Pro Met 
    1310                 1315                 1320             


Thr Gly  Gln Cys Arg Ser Arg  Thr Ser Thr Asp Leu  Asp Val Asp 
    1325                 1330                 1335             


Val Asp  Gln Pro Lys Glu Glu  Lys Lys Glu Cys Tyr  Tyr Asn Leu 
    1340                 1345                 1350             


Asn Asp  Ala Ser Leu Cys Asp  Asn Val Leu Ala Pro  Asn Val Thr 
    1355                 1360                 1365             


Lys Gln  Glu Cys Cys Cys Thr  Ser Gly Val Gly Trp  Gly Asp Asn 
    1370                 1375                 1380             


Cys Glu  Ile Phe Pro Cys Pro  Val Leu Gly Thr Ala  Glu Phe Thr 
    1385                 1390                 1395             


Glu Met  Cys Pro Lys Gly Lys  Gly Phe Val Pro Ala  Gly Glu Ser 
    1400                 1405                 1410             


Ser Ser  Glu Ala Gly Gly Glu  Asn Tyr Lys Asp Ala  Asp Glu Cys 
    1415                 1420                 1425             


Leu Leu  Phe Gly Gln Glu Ile  Cys Lys Asn Gly Phe  Cys Leu Asn 
    1430                 1435                 1440             


Thr Arg  Pro Gly Tyr Glu Cys  Tyr Cys Lys Gln Gly  Thr Tyr Tyr 
    1445                 1450                 1455             


Asp Pro  Val Lys Leu Gln Cys  Phe Asp Met Asp Glu  Cys Gln Asp 
    1460                 1465                 1470             


Pro Ser  Ser Cys Ile Asp Gly  Gln Cys Val Asn Thr  Glu Gly Ser 
    1475                 1480                 1485             


Tyr Asn  Cys Phe Cys Thr His  Pro Met Val Leu Asp  Ala Ser Glu 
    1490                 1495                 1500             


Lys Arg  Cys Ile Arg Pro Ala  Glu Ser Asn Glu Gln  Ile Glu Glu 
    1505                 1510                 1515             


Thr Asp  Val Tyr Gln Asp Leu  Cys Trp Glu His Leu  Ser Asp Glu 
    1520                 1525                 1530             


Tyr Val  Cys Ser Arg Pro Leu  Val Gly Lys Gln Thr  Thr Tyr Thr 
    1535                 1540                 1545             


Glu Cys  Cys Cys Leu Tyr Gly  Glu Ala Trp Gly Met  Gln Cys Ala 
    1550                 1555                 1560             


Leu Cys  Pro Leu Lys Asp Ser  Asp Asp Tyr Ala Gln  Leu Cys Asn 
    1565                 1570                 1575             


Ile Pro  Val Thr Gly Arg Arg  Gln Pro Tyr Gly Arg  Asp Ala Leu 
    1580                 1585                 1590             


Val Asp  Phe Ser Glu Gln Tyr  Thr Pro Glu Ala Asp  Pro Tyr Phe 
    1595                 1600                 1605             


Ile Gln  Asp Arg Phe Leu Asn  Ser Phe Glu Glu Leu  Gln Ala Glu 
    1610                 1615                 1620             


Glu Cys  Gly Ile Leu Asn Gly  Cys Glu Asn Gly Arg  Cys Val Arg 
    1625                 1630                 1635             


Val Gln  Glu Gly Tyr Thr Cys  Asp Cys Phe Asp Gly  Tyr His Leu 
    1640                 1645                 1650             


Asp Thr  Ala Lys Met Thr Cys  Val Asp Val Asn Glu  Cys Asp Glu 
    1655                 1660                 1665             


Leu Asn  Asn Arg Met Ser Leu  Cys Lys Asn Ala Lys  Cys Ile Asn 
    1670                 1675                 1680             


Thr Asp  Gly Ser Tyr Lys Cys  Leu Cys Leu Pro Gly  Tyr Val Pro 
    1685                 1690                 1695             


Ser Asp  Lys Pro Asn Tyr Cys  Thr Pro Leu Asn Thr  Ala Leu Asn 
    1700                 1705                 1710             


Leu Glu  Lys Asp Ser Asp Leu  Glu 
    1715                 1720     


<210>  7685
<211>  4755
<212>  DNA
<213>  Homosapiens

<400>  7685
actccagtga ctcgacttca aatgtggttt tggagtgcat cccagagttc tgtttgctaa     60

gcttcctact cctgtttcag agacaccact gaatacagag cagcgagcac tgaaggcttc    120

cctctttcct taaacctgtc gggttgtggg ctctctcttt tcccctcttg ctcctttctt    180

ttcttttttt ctgttttttt aaaccttcca aggcaagttc atggatacta agctgatgtg    240

tttgttgttc tttttctccc tgcctccgct cctagtgagt aaccacactg gccgcatcaa    300

ggtggtcttt actccgagca tctgtaaagt gacctgcacc aagggcagct gtcagaacag    360

ctgtgagaag gggaacacca ccactctcat tagtgagaat ggtcatgctg ccgacaccct    420

gacggccacg aacttccgag tggtaatttg ccatcttcca tgtatgaatg gtggccagtg    480

cagttcaagg gacaaatgtc agtgccctcc aaatttcaca ggaaaacttt gtcagatccc    540

agtccatggt gccagcgtgc ctaaacttta tcagcattcc cagcagccag gcaaggcgtt    600

ggggacgcat gtcatccatt caacacatac cttgcctctg accgtgacta gccagcaagg    660

agtcaaagtg aaatttcctc ctaacatagt caatatccat gtgaaacatc ctcctgaagc    720

ttccgtccag atacatcagg tttcaagaat tgatggccca acaggccaga agacaaaaga    780

agctcaacca ggccaatccc aagtctcgta ccaagggctt cctgtccaga agacccagac    840

catacattcc acatactccc accagcaggt cattcctcac gtctaccccg tggctgctaa    900

gacacagctt ggccggtgct tccaggaaac cattgggtca cagtgtggca aagcgctccc    960

tggcctttca aagcaagagg actgctgtgg aactgtgggt acctcctggg gctttaacaa   1020

atgccagaaa tgccccaaga aaccatctta tcatggatac aaccaaatga tggaatgcct   1080

accgggttat aagcgggtta acaacacctt ttgccaagat attaatgaat gtcagctaca   1140

aggtgtatgc cctaatggtg agtgtttgaa taccatgggc agctatcgat gtacctgcaa   1200

aataggattt gggccggatc ctaccttttc aagttgtgtt cctgatcccc ctgtgatctc   1260

ggaagagaaa gggccctgtt accgacttgt cagttctgga agacagtgta tgcaccctct   1320

gtctgttcac ctcaccaagc agctctgctg ttgtagtgtg ggcaaggcct ggggcccaca   1380

ctgtgagaaa tgtccccttc caggcacagc tgcttttaag gaaatctgtc ctggtggaat   1440

gggttatacg gtttctggcg ttcatagacg caggccaatc catcaccatg taggtaaagg   1500

acctgtattt gtcaagccaa agaacactca acctgttgct aaaagtactc atcctccacc   1560

tctcccagcc aaggaagagc cagtggaggc cctgaccttc tcccgggaac acgggccagg   1620

agtggcggag ccagaagtgg caactgcacc ccctgaaaag gaaatacctt cattggatca   1680

agagaaaacc aaacttgagc ctggtcaacc ccagctgtct ccaggcattt ccactattca   1740

tctgcatcca cagtttccag tagtgattga aaaaacatca cctcctgtgc ctgttgaagt   1800

agctcctgaa gcttctacgt ctagtgccag ccaagtgatt gctcctactc aagtgacaga   1860

aatcaatgaa tgtactgtga accctgatat ctgtggagca ggacactgca ttaacctacc   1920

agtgagatat acctgtatat gctacgaggg ctacaggttc agtgaacaac agaggaaatg   1980

tgtggatatt gatgagtgta ctcaggtcca acacctctgc tcccagggcc gctgtgaaaa   2040

caccgaggga agtttcttgt gcatttgccc agcaggattt atggccagtg aggagggtac   2100

taactgcata gatgttgacg aatgcctgag gccggacgtc tgtggggagg ggcactgtgt   2160

caatactgtg ggggccttcc ggtgtgaata ctgtgacagc gggtaccgca tgactcagag   2220

aggccgttgt gaggatattg atgaatgttt gaatccaagc acttgtccag atgagcagtg   2280

tgtgaattct cctggatctt accagtgcgt tccctgcaca gaaggattcc gaggctggaa   2340

tggacagtgc cttgatgtgg acgagtgcct ggaaccaaac gtctgcgcaa atggtgattg   2400

ttccaacctt gaaggctcct acatgtgttc atgccacaaa ggctataccc ggactccgga   2460

ccacaagcac tgtagagata ttgatgaatg tcagcaaggg aatctatgtg taaacgggca   2520

gtgcaaaaat accgagggct ccttcaggtg cacctgtgga caggggtacc agctgtcggc   2580

agctaaagac cagtgtgaag acattgatga atgccagcac cgtcatctct gtgctcatgg   2640

gcagtgcagg aacactgagg gctcttttca atgtgtgtgt gaccagggtt acagagcatc   2700

tgggcttgga gaccactgtg aagatatcaa tgaatgcttg gaggacaaga gtgtttgcca   2760

gagaggagac tgcattaata ctgcagggtc ctatgattgt acttgtccgg atggatttca   2820

gctagatgac aataaaacat gtcaagatat taatgaatgt gaacatccag ggctctgtgg   2880

tccgcaaggg gagtgcctaa acacagaggg ttctttccat tgtgtctgcc agcagggttt   2940

ctcaatctct gcagatggcc gtacgtgtga agatattgat gaatgtgtaa acaacactgt   3000

ttgtgacagt cacgggtttt gtgacaatac agctggctcc ttccgctgcc tctgttatca   3060

gggctttcaa gccccacagg atgggcaagg gtgtgtggat gtgaatgaat gtgaactgct   3120

cagtggggtg tgtggtgaag ccttctgtga aaacgtggaa gggtccttcc tgtgcgtgtg   3180

tgctgatgaa aaccaagagt acagccccat gactgggcag tgccgctccc ggacctccac   3240

agatttagat gtagatgtag atcaacccaa agaagaaaag aaagaatgct actataatct   3300

caatgacgcc agtctctgtg ataatgtgtt ggcccccaat gtcacgaaac aagaatgctg   3360

ctgtacatca ggcgtgggat ggggagataa ctgcgaaatc ttcccctgcc cggtcttggg   3420

aactgctgag ttcactgaaa tgtgtcccaa agggaaaggt tttgtgcctg ctggagaatc   3480

atcttctgaa gctggtggtg agaactataa agatgcagat gaatgcctac tttttggaca   3540

agaaatctgc aaaaatggtt tctgtttgaa cactcggcct gggtatgaat gctactgtaa   3600

gcaagggacg tactatgatc ctgtgaaact gcagtgcttt gatatggatg aatgtcaaga   3660

ccccagtagt tgtattgatg gccagtgtgt taatacagag ggctcttaca actgcttctg   3720

tactcacccc atggtcctgg atgcgtcaga aaaaagatgt atacgaccgg ctgagtcaaa   3780

cgaacaaata gaagaaactg atgtctacca agatttgtgc tgggaacatc tgagtgatga   3840

atacgtgtgt agccggcctc ttgtgggcaa gcagacaacg tacactgagt gctgctgtct   3900

gtatggagag gcctggggca tgcagtgtgc cctctgcccc ctgaaggatt cagatgacta   3960

tgctcagctg tgtaacatcc ccgtgacggg acgccggcag ccatatggac gggacgcctt   4020

ggttgacttc agtgaacagt atactccaga agccgatccc tacttcatcc aagaccgttt   4080

tctaaatagc tttgaggagt tacaggctga ggaatgcggc atcctcaatg gatgtgaaaa   4140

tggtcgctgt gtgagggtcc aggaaggtta cacctgcgat tgctttgatg ggtatcactt   4200

ggatacggcc aagatgacct gtgtcgatgt aaatgaatgc gatgagttga acaaccggat   4260

gtctctctgc aagaatgcca agtgcattaa caccgatggt tcctacaagt gtttgtgtct   4320

gccaggctac gtgccttctg acaagccaaa ctactgcact ccgttgaata ccgccttgaa   4380

tttagagaaa gacagtgacc tggagtgaaa cagaatctac ataacctaag cccatatact   4440

ctgcactgtg taaaggaaaa gggagaaatg tattatactt gagacattgc acctaccccg   4500

gaaggctgga aatacagaaa cagcatggaa ttgcaagtcc tctgaagaca atgagaggat   4560

ttaggatgag cccgataggt gtggcagacc aaatggacat ttctctaaaa aaccagtata   4620

tatagtctgt tcatatgtaa aattcaatgg aagagaggtg gaacagtgct gttattttaa   4680

acagaaggtt gtattattat gttgttttgt ttttttacta ttgcttgatt aaatttggca   4740

tttaaatagt ggtgg                                                    4755


<210>  7686
<211>  1395
<212>  PRT
<213>  Homosapiens

<400>  7686

Met Asp Thr Lys Leu Met Cys Leu Leu Phe Phe Phe Ser Leu Pro Pro 
1               5                   10                  15      


Leu Leu Val Ser Asn His Thr Gly Arg Ile Lys Val Val Phe Thr Pro 
            20                  25                  30          


Ser Ile Cys Lys Val Thr Cys Thr Lys Gly Ser Cys Gln Asn Ser Cys 
        35                  40                  45              


Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser Glu Asn Gly His Ala Ala 
    50                  55                  60                  


Asp Thr Leu Thr Ala Thr Asn Phe Arg Val Val Ile Cys His Leu Pro 
65                  70                  75                  80  


Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asp Lys Cys Gln Cys Pro 
                85                  90                  95      


Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile Pro Val His Gly Ala Ser 
            100                 105                 110         


Val Pro Lys Leu Tyr Gln His Ser Gln Gln Pro Gly Lys Ala Leu Gly 
        115                 120                 125             


Thr His Val Ile His Ser Thr His Thr Leu Pro Leu Thr Val Thr Ser 
    130                 135                 140                 


Gln Gln Gly Val Lys Val Lys Phe Pro Pro Asn Ile Val Asn Ile His 
145                 150                 155                 160 


Val Lys His Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ser Arg 
                165                 170                 175     


Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys Glu Ala Gln Pro Gly Gln 
            180                 185                 190         


Ser Gln Val Ser Tyr Gln Gly Leu Pro Val Gln Lys Thr Gln Thr Ile 
        195                 200                 205             


His Ser Thr Tyr Ser His Gln Gln Val Ile Pro His Val Tyr Pro Val 
    210                 215                 220                 


Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe Gln Glu Thr Ile Gly Ser 
225                 230                 235                 240 


Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser Lys Gln Glu Asp Cys Cys 
                245                 250                 255     


Gly Thr Val Gly Thr Ser Trp Gly Phe Asn Lys Cys Gln Lys Cys Pro 
            260                 265                 270         


Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln Met Met Glu Cys Leu Pro 
        275                 280                 285             


Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys Gln Asp Ile Asn Glu Cys 
    290                 295                 300                 


Gln Leu Gln Gly Val Cys Pro Asn Gly Glu Cys Leu Asn Thr Met Gly 
305                 310                 315                 320 


Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe Gly Pro Asp Pro Thr Phe 
                325                 330                 335     


Ser Ser Cys Val Pro Asp Pro Pro Val Ile Ser Glu Glu Lys Gly Pro 
            340                 345                 350         


Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln Cys Met His Pro Leu Ser 
        355                 360                 365             


Val His Leu Thr Lys Gln Leu Cys Cys Cys Ser Val Gly Lys Ala Trp 
    370                 375                 380                 


Gly Pro His Cys Glu Lys Cys Pro Leu Pro Gly Thr Ala Ala Phe Lys 
385                 390                 395                 400 


Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr Val Ser Gly Val His Arg 
                405                 410                 415     


Arg Arg Pro Ile His His His Val Gly Lys Gly Pro Val Phe Val Lys 
            420                 425                 430         


Pro Lys Asn Thr Gln Pro Val Ala Lys Ser Thr His Pro Pro Pro Leu 
        435                 440                 445             


Pro Ala Lys Glu Glu Pro Val Glu Ala Leu Thr Phe Ser Arg Glu His 
    450                 455                 460                 


Gly Pro Gly Val Ala Glu Pro Glu Val Ala Thr Ala Pro Pro Glu Lys 
465                 470                 475                 480 


Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr Lys Leu Glu Pro Gly Gln 
                485                 490                 495     


Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile His Leu His Pro Gln Phe 
            500                 505                 510         


Pro Val Val Ile Glu Lys Thr Ser Pro Pro Val Pro Val Glu Val Ala 
        515                 520                 525             


Pro Glu Ala Ser Thr Ser Ser Ala Ser Gln Val Ile Ala Pro Thr Gln 
    530                 535                 540                 


Val Thr Glu Ile Asn Glu Cys Thr Val Asn Pro Asp Ile Cys Gly Ala 
545                 550                 555                 560 


Gly His Cys Ile Asn Leu Pro Val Arg Tyr Thr Cys Ile Cys Tyr Glu 
                565                 570                 575     


Gly Tyr Arg Phe Ser Glu Gln Gln Arg Lys Cys Val Asp Ile Asp Glu 
            580                 585                 590         


Cys Thr Gln Val Gln His Leu Cys Ser Gln Gly Arg Cys Glu Asn Thr 
        595                 600                 605             


Glu Gly Ser Phe Leu Cys Ile Cys Pro Ala Gly Phe Met Ala Ser Glu 
    610                 615                 620                 


Glu Gly Thr Asn Cys Ile Asp Val Asp Glu Cys Leu Arg Pro Asp Val 
625                 630                 635                 640 


Cys Gly Glu Gly His Cys Val Asn Thr Val Gly Ala Phe Arg Cys Glu 
                645                 650                 655     


Tyr Cys Asp Ser Gly Tyr Arg Met Thr Gln Arg Gly Arg Cys Glu Asp 
            660                 665                 670         


Ile Asp Glu Cys Leu Asn Pro Ser Thr Cys Pro Asp Glu Gln Cys Val 
        675                 680                 685             


Asn Ser Pro Gly Ser Tyr Gln Cys Val Pro Cys Thr Glu Gly Phe Arg 
    690                 695                 700                 


Gly Trp Asn Gly Gln Cys Leu Asp Val Asp Glu Cys Leu Glu Pro Asn 
705                 710                 715                 720 


Val Cys Ala Asn Gly Asp Cys Ser Asn Leu Glu Gly Ser Tyr Met Cys 
                725                 730                 735     


Ser Cys His Lys Gly Tyr Thr Arg Thr Pro Asp His Lys His Cys Arg 
            740                 745                 750         


Asp Ile Asp Glu Cys Gln Gln Gly Asn Leu Cys Val Asn Gly Gln Cys 
        755                 760                 765             


Lys Asn Thr Glu Gly Ser Phe Arg Cys Thr Cys Gly Gln Gly Tyr Gln 
    770                 775                 780                 


Leu Ser Ala Ala Lys Asp Gln Cys Glu Asp Ile Asp Glu Cys Gln His 
785                 790                 795                 800 


Arg His Leu Cys Ala His Gly Gln Cys Arg Asn Thr Glu Gly Ser Phe 
                805                 810                 815     


Gln Cys Val Cys Asp Gln Gly Tyr Arg Ala Ser Gly Leu Gly Asp His 
            820                 825                 830         


Cys Glu Asp Ile Asn Glu Cys Leu Glu Asp Lys Ser Val Cys Gln Arg 
        835                 840                 845             


Gly Asp Cys Ile Asn Thr Ala Gly Ser Tyr Asp Cys Thr Cys Pro Asp 
    850                 855                 860                 


Gly Phe Gln Leu Asp Asp Asn Lys Thr Cys Gln Asp Ile Asn Glu Cys 
865                 870                 875                 880 


Glu His Pro Gly Leu Cys Gly Pro Gln Gly Glu Cys Leu Asn Thr Glu 
                885                 890                 895     


Gly Ser Phe His Cys Val Cys Gln Gln Gly Phe Ser Ile Ser Ala Asp 
            900                 905                 910         


Gly Arg Thr Cys Glu Asp Ile Asp Glu Cys Val Asn Asn Thr Val Cys 
        915                 920                 925             


Asp Ser His Gly Phe Cys Asp Asn Thr Ala Gly Ser Phe Arg Cys Leu 
    930                 935                 940                 


Cys Tyr Gln Gly Phe Gln Ala Pro Gln Asp Gly Gln Gly Cys Val Asp 
945                 950                 955                 960 


Val Asn Glu Cys Glu Leu Leu Ser Gly Val Cys Gly Glu Ala Phe Cys 
                965                 970                 975     


Glu Asn Val Glu Gly Ser Phe Leu Cys Val Cys Ala Asp Glu Asn Gln 
            980                 985                 990         


Glu Tyr Ser Pro Met Thr Gly Gln  Cys Arg Ser Arg Thr  Ser Thr Asp 
        995                 1000                 1005             


Leu Asp  Val Asp Val Asp Gln  Pro Lys Glu Glu Lys  Lys Glu Cys 
    1010                 1015                 1020             


Tyr Tyr  Asn Leu Asn Asp Ala  Ser Leu Cys Asp Asn  Val Leu Ala 
    1025                 1030                 1035             


Pro Asn  Val Thr Lys Gln Glu  Cys Cys Cys Thr Ser  Gly Val Gly 
    1040                 1045                 1050             


Trp Gly  Asp Asn Cys Glu Ile  Phe Pro Cys Pro Val  Leu Gly Thr 
    1055                 1060                 1065             


Ala Glu  Phe Thr Glu Met Cys  Pro Lys Gly Lys Gly  Phe Val Pro 
    1070                 1075                 1080             


Ala Gly  Glu Ser Ser Ser Glu  Ala Gly Gly Glu Asn  Tyr Lys Asp 
    1085                 1090                 1095             


Ala Asp  Glu Cys Leu Leu Phe  Gly Gln Glu Ile Cys  Lys Asn Gly 
    1100                 1105                 1110             


Phe Cys  Leu Asn Thr Arg Pro  Gly Tyr Glu Cys Tyr  Cys Lys Gln 
    1115                 1120                 1125             


Gly Thr  Tyr Tyr Asp Pro Val  Lys Leu Gln Cys Phe  Asp Met Asp 
    1130                 1135                 1140             


Glu Cys  Gln Asp Pro Ser Ser  Cys Ile Asp Gly Gln  Cys Val Asn 
    1145                 1150                 1155             


Thr Glu  Gly Ser Tyr Asn Cys  Phe Cys Thr His Pro  Met Val Leu 
    1160                 1165                 1170             


Asp Ala  Ser Glu Lys Arg Cys  Ile Arg Pro Ala Glu  Ser Asn Glu 
    1175                 1180                 1185             


Gln Ile  Glu Glu Thr Asp Val  Tyr Gln Asp Leu Cys  Trp Glu His 
    1190                 1195                 1200             


Leu Ser  Asp Glu Tyr Val Cys  Ser Arg Pro Leu Val  Gly Lys Gln 
    1205                 1210                 1215             


Thr Thr  Tyr Thr Glu Cys Cys  Cys Leu Tyr Gly Glu  Ala Trp Gly 
    1220                 1225                 1230             


Met Gln  Cys Ala Leu Cys Pro  Leu Lys Asp Ser Asp  Asp Tyr Ala 
    1235                 1240                 1245             


Gln Leu  Cys Asn Ile Pro Val  Thr Gly Arg Arg Gln  Pro Tyr Gly 
    1250                 1255                 1260             


Arg Asp  Ala Leu Val Asp Phe  Ser Glu Gln Tyr Thr  Pro Glu Ala 
    1265                 1270                 1275             


Asp Pro  Tyr Phe Ile Gln Asp  Arg Phe Leu Asn Ser  Phe Glu Glu 
    1280                 1285                 1290             


Leu Gln  Ala Glu Glu Cys Gly  Ile Leu Asn Gly Cys  Glu Asn Gly 
    1295                 1300                 1305             


Arg Cys  Val Arg Val Gln Glu  Gly Tyr Thr Cys Asp  Cys Phe Asp 
    1310                 1315                 1320             


Gly Tyr  His Leu Asp Thr Ala  Lys Met Thr Cys Val  Asp Val Asn 
    1325                 1330                 1335             


Glu Cys  Asp Glu Leu Asn Asn  Arg Met Ser Leu Cys  Lys Asn Ala 
    1340                 1345                 1350             


Lys Cys  Ile Asn Thr Asp Gly  Ser Tyr Lys Cys Leu  Cys Leu Pro 
    1355                 1360                 1365             


Gly Tyr  Val Pro Ser Asp Lys  Pro Asn Tyr Cys Thr  Pro Leu Asn 
    1370                 1375                 1380             


Thr Ala  Leu Asn Leu Glu Lys  Asp Ser Asp Leu Glu  
    1385                 1390                 1395 


<210>  7687
<211>  5235
<212>  DNA
<213>  Homosapiens

<400>  7687
actccagtga ctcgacttca aatgtggttt tggagtgcat cccagagttc tgtttgctaa     60

gcttcctact cctgtttcag agacaccact gaatacagag cagcgagcac tgaaggcttc    120

cctctttcct taaacctgtc gggttgtggg ctctctcttt tcccctcttg ctcctttctt    180

ttcttttttt ctgttttttt aaaccttcca aggcaagttc atggatacta agctgatgtg    240

tttgttgttc tttttctccc tgcctccgct cctagtgagt aaccacactg gccgcatcaa    300

ggtggtcttt actccgagca tctgtaaagt gacctgcacc aagggcagct gtcagaacag    360

ctgtgagaag gggaacacca ccactctcat tagtgagaat ggtcatgctg ccgacaccct    420

gacggccacg aacttccgag tggtaatttg ccatcttcca tgtatgaatg gtggccagtg    480

cagttcaagg gacaaatgtc agtgccctcc aaatttcaca ggaaaacttt gtcagatccc    540

agtccatggt gccagcgtgc ctaaacttta tcagcattcc cagcagccag gcaaggcgtt    600

ggggacgcat gtcatccatt caacacatac cttgcctctg accgtgacta gccagcaagg    660

agtcaaagtg aaatttcctc ctaacatagt caatatccat gtgaaacatc ctcctgaagc    720

ttccgtccag atacatcagg tttcaagaat tgatggccca acaggccaga agacaaaaga    780

agctcaacca ggccaatccc aagtctcgta ccaagggctt cctgtccaga agacccagac    840

catacattcc acatactccc accagcaggt cattcctcac gtctaccccg tggctgctaa    900

gacacagctt ggccggtgct tccaggaaac cattgggtca cagtgtggca aagcgctccc    960

tggcctttca aagcaagagg actgctgtgg aactgtgggt acctcctggg gctttaacaa   1020

atgccagaaa tgccccaaga aaccatctta tcatggatac aaccaaatga tggaatgcct   1080

accgggttat aagcgggtta acaacacctt ttgccaagat attaatgaat gtcagctaca   1140

aggtgtatgc cctaatggtg agtgtttgaa taccatgggc agctatcgat gtacctgcaa   1200

aataggattt gggccggatc ctaccttttc aagttgtgtt cctgatcccc ctgtgatctc   1260

ggaagagaaa gggccctgtt accgacttgt cagttctgga agacagtgta tgcaccctct   1320

gtctgttcac ctcaccaagc agctctgctg ttgtagtgtg ggcaaggcct ggggcccaca   1380

ctgtgagaaa tgtccccttc caggcacagc tgcttttaag gaaatctgtc ctggtggaat   1440

gggttatacg gtttctggcg ttcatagacg caggccaatc catcaccatg taggtaaagg   1500

acctgtattt gtcaagccaa agaacactca acctgttgct aaaagtactc atcctccacc   1560

tctcccagcc aaggaagagc cagtggaggc cctgaccttc tcccgggaac acgggccagg   1620

agtggcggag ccagaagtgg caactgcacc ccctgaaaag gaaatacctt cattggatca   1680

agagaaaacc aaacttgagc ctggtcaacc ccagctgtct ccaggcattt ccactattca   1740

tctgcatcca cagtttccag tagtgattga aaaaacatca cctcctgtgc ctgttgaagt   1800

agctcctgaa gcttctacgt ctagtgccag ccaagtgatt gctcctactc aagtgacaga   1860

aatcaatgaa tgtactgtga accctgatat ctgtggagca ggacactgca ttaacctacc   1920

agtgagatat acctgtatat gctacgaggg ctacaggttc agtgaacaac agaggaaatg   1980

tgtggatatt gatgagtgta ctcaggtcca acacctctgc tcccagggcc gctgtgaaaa   2040

caccgaggga agtttcttgt gcatttgccc agcaggattt atggccagtg aggagggtac   2100

taactgcata gatgttgacg aatgcctgag gccggacgtc tgtggggagg ggcactgtgt   2160

caatactgtg ggggccttcc ggtgtgaata ctgtgacagc gggtaccgca tgactcagag   2220

aggccgttgt gaggatattg atgaatgttt gaatccaagc acttgtccag atgagcagtg   2280

tgtgaattct cctggatctt accagtgcgt tccctgcaca gaaggattcc gaggctggaa   2340

tggacagtgc cttgatgtgg acgagtgcct ggaaccaaac gtctgcgcaa atggtgattg   2400

ttccaacctt gaaggctcct acatgtgttc atgccacaaa ggctataccc ggactccgga   2460

ccacaagcac tgtagagata ttgatgaatg tcagcaaggg aatctatgtg taaacgggca   2520

gtgcaaaaat accgagggct ccttcaggtg cacctgtgga caggggtacc agctgtcggc   2580

agctaaagac cagtgtgaag acattgatga atgccagcac cgtcatctct gtgctcatgg   2640

gcagtgcagg aacactgagg gctcttttca atgtgtgtgt gaccagggtt acagagcatc   2700

tgggcttgga gaccactgtg aagatatcaa tgaatgcttg gaggacaaga gtgtttgcca   2760

gagaggagac tgcattaata ctgcagggtc ctatgattgt acttgtccgg atggatttca   2820

gctagatgac aataaaacat gtcaagatat taatgaatgt gaacatccag ggctctgtgg   2880

tccgcaaggg gagtgcctaa acacagaggg ttctttccat tgtgtctgcc agcagggttt   2940

ctcaatctct gcagatggcc gtacgtgtga agatattgat gaatgtgtaa acaacactgt   3000

ttgtgacagt cacgggtttt gtgacaatac agctggctcc ttccgctgcc tctgttatca   3060

gggctttcaa gccccacagg atgggcaagg gtgtgtggat gtgaatgaat gtgaactgct   3120

cagtggggtg tgtggtgaag ccttctgtga aaacgtggaa gggtccttcc tgtgcgtgtg   3180

tgctgatgaa aaccaagagt acagccccat gactgggcag tgccgctccc ggacctccac   3240

agatttagat gtagatgtag atcaacccaa agaagaaaag aaagaatgct actataatct   3300

caatgacgcc agtctctgtg ataatgtgtt ggcccccaat gtcacgaaac aagaatgctg   3360

ctgtacatca ggcgtgggat ggggagataa ctgcgaaatc ttcccctgcc cggtcttggg   3420

aactgctgag ttcactgaaa tgtgtcccaa agggaaaggt tttgtgcctg ctggagaatc   3480

atcttctgaa gctggtggtg agaactataa agatgcagat gaatgcctac tttttggaca   3540

agaaatctgc aaaaatggtt tctgtttgaa cactcggcct gggtatgaat gctactgtaa   3600

gcaagggacg tactatgatc ctgtgaaact gcagtgcttt gatatggatg aatgtcaaga   3660

ccccagtagt tgtattgatg gccagtgtgt taatacagag ggctcttaca actgcttctg   3720

tactcacccc atggtcctgg atgcgtcaga aaaaagatgt atacgaccgg ctgagtcaaa   3780

cgaacaaata gaagaaactg atgtctacca agatttgtgc tgggaacatc tgagtgatga   3840

atacgtgtgt agccggcctc ttgtgggcaa gcagacaacg tacactgagt gctgctgtct   3900

gtatggagag gcctggggca tgcagtgtgc cctctgcccc ctgaaggatt cagatgacta   3960

tgctcagctg tgtaacatcc ccgtgacggg acgccggcag ccatatggac gggacgcctt   4020

ggttgacttc agtgaacagt atactccaga agccgatccc tacttcatcc aagaccgttt   4080

tctaaatagc tttgaggagt tacaggctga ggaatgcggc atcctcaatg gatgtgaaaa   4140

tggtcgctgt gtgagggtcc aggaaggtta cacctgcgat tgctttgatg ggtatcactt   4200

ggatacggcc aagatgacct gtgtcgatgt aaatgaatgc gatgagttga acaaccggat   4260

gtctctctgc aagaatgcca agtgcattaa caccgatggt tcctacaagt gtttgtgtct   4320

gccaggctac gtgccttctg acaagccaaa ctactgcact ccgttgaata ccgccttgaa   4380

tttagagaaa gacagtgacc tggagtgaaa cagaatctac ataacctaag cccatatact   4440

ctgcactgtg taaaggaaaa gggagaaatg tattatactt gagacattgc acctaccccg   4500

gaaggctgga aatacagaaa cagcatggaa ttgcaagtcc tctgaagaca atgagaggat   4560

ttaggatgag cccgataggt gtggcagacc aaatggacat ttctctaaaa aaccagtata   4620

tatagtctgt tcatatgtaa aattcaatgg aagagaggtg gaacagtgct gttattttaa   4680

acagaaggtt gtattattat gttgttttgt ttttttacta ttgcttgatt aaatttggca   4740

tttaaatagt ggtggaaata ttttatataa ttttcatttt ttggttgtgc agttccttgg   4800

ctactgtttt tcttttactt cagtttttta aaaatctcaa atgaaaaagt cttcgataca   4860

atattgttaa gctgtattat aagtattgtt acacagggtt atgcaattcc cggcctggag   4920

catttttgaa attcaaattg tctgtcctgt ggagcaggca gtgattttgt tccaaaactt   4980

tgtatacaca tttggagaaa agtactttat attttcagtg ttttgtctga ttttaatgtc   5040

cgttcttagc caagctgcta gcaggtgtta attggatccc tttccttcac tgaaatggaa   5100

gagtttataa gcttacgtta gtattgtaat atgtaaagta agcccaacaa aaatttttaa   5160

aaatttgatg atccccaata tatctaccat tgtatgttaa ataaatcacc atttttgtag   5220

aaaaaattct acctg                                                    5235


<210>  7688
<211>  1395
<212>  PRT
<213>  Homosapiens

<400>  7688

Met Asp Thr Lys Leu Met Cys Leu Leu Phe Phe Phe Ser Leu Pro Pro 
1               5                   10                  15      


Leu Leu Val Ser Asn His Thr Gly Arg Ile Lys Val Val Phe Thr Pro 
            20                  25                  30          


Ser Ile Cys Lys Val Thr Cys Thr Lys Gly Ser Cys Gln Asn Ser Cys 
        35                  40                  45              


Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser Glu Asn Gly His Ala Ala 
    50                  55                  60                  


Asp Thr Leu Thr Ala Thr Asn Phe Arg Val Val Ile Cys His Leu Pro 
65                  70                  75                  80  


Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asp Lys Cys Gln Cys Pro 
                85                  90                  95      


Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile Pro Val His Gly Ala Ser 
            100                 105                 110         


Val Pro Lys Leu Tyr Gln His Ser Gln Gln Pro Gly Lys Ala Leu Gly 
        115                 120                 125             


Thr His Val Ile His Ser Thr His Thr Leu Pro Leu Thr Val Thr Ser 
    130                 135                 140                 


Gln Gln Gly Val Lys Val Lys Phe Pro Pro Asn Ile Val Asn Ile His 
145                 150                 155                 160 


Val Lys His Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ser Arg 
                165                 170                 175     


Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys Glu Ala Gln Pro Gly Gln 
            180                 185                 190         


Ser Gln Val Ser Tyr Gln Gly Leu Pro Val Gln Lys Thr Gln Thr Ile 
        195                 200                 205             


His Ser Thr Tyr Ser His Gln Gln Val Ile Pro His Val Tyr Pro Val 
    210                 215                 220                 


Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe Gln Glu Thr Ile Gly Ser 
225                 230                 235                 240 


Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser Lys Gln Glu Asp Cys Cys 
                245                 250                 255     


Gly Thr Val Gly Thr Ser Trp Gly Phe Asn Lys Cys Gln Lys Cys Pro 
            260                 265                 270         


Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln Met Met Glu Cys Leu Pro 
        275                 280                 285             


Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys Gln Asp Ile Asn Glu Cys 
    290                 295                 300                 


Gln Leu Gln Gly Val Cys Pro Asn Gly Glu Cys Leu Asn Thr Met Gly 
305                 310                 315                 320 


Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe Gly Pro Asp Pro Thr Phe 
                325                 330                 335     


Ser Ser Cys Val Pro Asp Pro Pro Val Ile Ser Glu Glu Lys Gly Pro 
            340                 345                 350         


Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln Cys Met His Pro Leu Ser 
        355                 360                 365             


Val His Leu Thr Lys Gln Leu Cys Cys Cys Ser Val Gly Lys Ala Trp 
    370                 375                 380                 


Gly Pro His Cys Glu Lys Cys Pro Leu Pro Gly Thr Ala Ala Phe Lys 
385                 390                 395                 400 


Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr Val Ser Gly Val His Arg 
                405                 410                 415     


Arg Arg Pro Ile His His His Val Gly Lys Gly Pro Val Phe Val Lys 
            420                 425                 430         


Pro Lys Asn Thr Gln Pro Val Ala Lys Ser Thr His Pro Pro Pro Leu 
        435                 440                 445             


Pro Ala Lys Glu Glu Pro Val Glu Ala Leu Thr Phe Ser Arg Glu His 
    450                 455                 460                 


Gly Pro Gly Val Ala Glu Pro Glu Val Ala Thr Ala Pro Pro Glu Lys 
465                 470                 475                 480 


Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr Lys Leu Glu Pro Gly Gln 
                485                 490                 495     


Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile His Leu His Pro Gln Phe 
            500                 505                 510         


Pro Val Val Ile Glu Lys Thr Ser Pro Pro Val Pro Val Glu Val Ala 
        515                 520                 525             


Pro Glu Ala Ser Thr Ser Ser Ala Ser Gln Val Ile Ala Pro Thr Gln 
    530                 535                 540                 


Val Thr Glu Ile Asn Glu Cys Thr Val Asn Pro Asp Ile Cys Gly Ala 
545                 550                 555                 560 


Gly His Cys Ile Asn Leu Pro Val Arg Tyr Thr Cys Ile Cys Tyr Glu 
                565                 570                 575     


Gly Tyr Arg Phe Ser Glu Gln Gln Arg Lys Cys Val Asp Ile Asp Glu 
            580                 585                 590         


Cys Thr Gln Val Gln His Leu Cys Ser Gln Gly Arg Cys Glu Asn Thr 
        595                 600                 605             


Glu Gly Ser Phe Leu Cys Ile Cys Pro Ala Gly Phe Met Ala Ser Glu 
    610                 615                 620                 


Glu Gly Thr Asn Cys Ile Asp Val Asp Glu Cys Leu Arg Pro Asp Val 
625                 630                 635                 640 


Cys Gly Glu Gly His Cys Val Asn Thr Val Gly Ala Phe Arg Cys Glu 
                645                 650                 655     


Tyr Cys Asp Ser Gly Tyr Arg Met Thr Gln Arg Gly Arg Cys Glu Asp 
            660                 665                 670         


Ile Asp Glu Cys Leu Asn Pro Ser Thr Cys Pro Asp Glu Gln Cys Val 
        675                 680                 685             


Asn Ser Pro Gly Ser Tyr Gln Cys Val Pro Cys Thr Glu Gly Phe Arg 
    690                 695                 700                 


Gly Trp Asn Gly Gln Cys Leu Asp Val Asp Glu Cys Leu Glu Pro Asn 
705                 710                 715                 720 


Val Cys Ala Asn Gly Asp Cys Ser Asn Leu Glu Gly Ser Tyr Met Cys 
                725                 730                 735     


Ser Cys His Lys Gly Tyr Thr Arg Thr Pro Asp His Lys His Cys Arg 
            740                 745                 750         


Asp Ile Asp Glu Cys Gln Gln Gly Asn Leu Cys Val Asn Gly Gln Cys 
        755                 760                 765             


Lys Asn Thr Glu Gly Ser Phe Arg Cys Thr Cys Gly Gln Gly Tyr Gln 
    770                 775                 780                 


Leu Ser Ala Ala Lys Asp Gln Cys Glu Asp Ile Asp Glu Cys Gln His 
785                 790                 795                 800 


Arg His Leu Cys Ala His Gly Gln Cys Arg Asn Thr Glu Gly Ser Phe 
                805                 810                 815     


Gln Cys Val Cys Asp Gln Gly Tyr Arg Ala Ser Gly Leu Gly Asp His 
            820                 825                 830         


Cys Glu Asp Ile Asn Glu Cys Leu Glu Asp Lys Ser Val Cys Gln Arg 
        835                 840                 845             


Gly Asp Cys Ile Asn Thr Ala Gly Ser Tyr Asp Cys Thr Cys Pro Asp 
    850                 855                 860                 


Gly Phe Gln Leu Asp Asp Asn Lys Thr Cys Gln Asp Ile Asn Glu Cys 
865                 870                 875                 880 


Glu His Pro Gly Leu Cys Gly Pro Gln Gly Glu Cys Leu Asn Thr Glu 
                885                 890                 895     


Gly Ser Phe His Cys Val Cys Gln Gln Gly Phe Ser Ile Ser Ala Asp 
            900                 905                 910         


Gly Arg Thr Cys Glu Asp Ile Asp Glu Cys Val Asn Asn Thr Val Cys 
        915                 920                 925             


Asp Ser His Gly Phe Cys Asp Asn Thr Ala Gly Ser Phe Arg Cys Leu 
    930                 935                 940                 


Cys Tyr Gln Gly Phe Gln Ala Pro Gln Asp Gly Gln Gly Cys Val Asp 
945                 950                 955                 960 


Val Asn Glu Cys Glu Leu Leu Ser Gly Val Cys Gly Glu Ala Phe Cys 
                965                 970                 975     


Glu Asn Val Glu Gly Ser Phe Leu Cys Val Cys Ala Asp Glu Asn Gln 
            980                 985                 990         


Glu Tyr Ser Pro Met Thr Gly Gln  Cys Arg Ser Arg Thr  Ser Thr Asp 
        995                 1000                 1005             


Leu Asp  Val Asp Val Asp Gln  Pro Lys Glu Glu Lys  Lys Glu Cys 
    1010                 1015                 1020             


Tyr Tyr  Asn Leu Asn Asp Ala  Ser Leu Cys Asp Asn  Val Leu Ala 
    1025                 1030                 1035             


Pro Asn  Val Thr Lys Gln Glu  Cys Cys Cys Thr Ser  Gly Val Gly 
    1040                 1045                 1050             


Trp Gly  Asp Asn Cys Glu Ile  Phe Pro Cys Pro Val  Leu Gly Thr 
    1055                 1060                 1065             


Ala Glu  Phe Thr Glu Met Cys  Pro Lys Gly Lys Gly  Phe Val Pro 
    1070                 1075                 1080             


Ala Gly  Glu Ser Ser Ser Glu  Ala Gly Gly Glu Asn  Tyr Lys Asp 
    1085                 1090                 1095             


Ala Asp  Glu Cys Leu Leu Phe  Gly Gln Glu Ile Cys  Lys Asn Gly 
    1100                 1105                 1110             


Phe Cys  Leu Asn Thr Arg Pro  Gly Tyr Glu Cys Tyr  Cys Lys Gln 
    1115                 1120                 1125             


Gly Thr  Tyr Tyr Asp Pro Val  Lys Leu Gln Cys Phe  Asp Met Asp 
    1130                 1135                 1140             


Glu Cys  Gln Asp Pro Ser Ser  Cys Ile Asp Gly Gln  Cys Val Asn 
    1145                 1150                 1155             


Thr Glu  Gly Ser Tyr Asn Cys  Phe Cys Thr His Pro  Met Val Leu 
    1160                 1165                 1170             


Asp Ala  Ser Glu Lys Arg Cys  Ile Arg Pro Ala Glu  Ser Asn Glu 
    1175                 1180                 1185             


Gln Ile  Glu Glu Thr Asp Val  Tyr Gln Asp Leu Cys  Trp Glu His 
    1190                 1195                 1200             


Leu Ser  Asp Glu Tyr Val Cys  Ser Arg Pro Leu Val  Gly Lys Gln 
    1205                 1210                 1215             


Thr Thr  Tyr Thr Glu Cys Cys  Cys Leu Tyr Gly Glu  Ala Trp Gly 
    1220                 1225                 1230             


Met Gln  Cys Ala Leu Cys Pro  Leu Lys Asp Ser Asp  Asp Tyr Ala 
    1235                 1240                 1245             


Gln Leu  Cys Asn Ile Pro Val  Thr Gly Arg Arg Gln  Pro Tyr Gly 
    1250                 1255                 1260             


Arg Asp  Ala Leu Val Asp Phe  Ser Glu Gln Tyr Thr  Pro Glu Ala 
    1265                 1270                 1275             


Asp Pro  Tyr Phe Ile Gln Asp  Arg Phe Leu Asn Ser  Phe Glu Glu 
    1280                 1285                 1290             


Leu Gln  Ala Glu Glu Cys Gly  Ile Leu Asn Gly Cys  Glu Asn Gly 
    1295                 1300                 1305             


Arg Cys  Val Arg Val Gln Glu  Gly Tyr Thr Cys Asp  Cys Phe Asp 
    1310                 1315                 1320             


Gly Tyr  His Leu Asp Thr Ala  Lys Met Thr Cys Val  Asp Val Asn 
    1325                 1330                 1335             


Glu Cys  Asp Glu Leu Asn Asn  Arg Met Ser Leu Cys  Lys Asn Ala 
    1340                 1345                 1350             


Lys Cys  Ile Asn Thr Asp Gly  Ser Tyr Lys Cys Leu  Cys Leu Pro 
    1355                 1360                 1365             


Gly Tyr  Val Pro Ser Asp Lys  Pro Asn Tyr Cys Thr  Pro Leu Asn 
    1370                 1375                 1380             


Thr Ala  Leu Asn Leu Glu Lys  Asp Ser Asp Leu Glu  
    1385                 1390                 1395 


<210>  7689
<211>  5369
<212>  DNA
<213>  Homosapiens

<400>  7689
actccagtga ctcgacttca aatgtggttt tggagtgcat cccagagttc tgtttgctaa     60

gcttcctact cctgtttcag agacaccact gaatacagag cagcgagcac tgaaggcttc    120

cctctttcct taaacctgtc gggttgtggg ctctctcttt tcccctcttg ctcctttctt    180

ttcttttttt ctgttttttt aaaccttcca aggcaagttc atggatacta agctgatgtg    240

tttgttgttc tttttctccc tgcctccgct cctagtgagt aaccacactg gccgcatcaa    300

ggtggtcttt actccgagca tctgtaaagt gacctgcacc aagggcagct gtcagaacag    360

ctgtgagaag gggaacacca ccactctcat tagtgagaat ggtcatgctg ccgacaccct    420

gacggccacg aacttccgag tggtaatttg ccatcttcca tgtatgaatg gtggccagtg    480

cagttcaagg gacaaatgtc agtgccctcc aaatttcaca ggaaaacttt gtcagatccc    540

agtccatggt gccagcgtgc ctaaacttta tcagcattcc cagcagccag gcaaggcgtt    600

ggggacgcat gtcatccatt caacacatac cttgcctctg accgtgacta gccagcaagg    660

agtcaaagtg aaatttcctc ctaacatagt caatatccat gtgaaacatc ctcctgaagc    720

ttccgtccag atacatcagg tttcaagaat tgatggccca acaggccaga agacaaaaga    780

agctcaacca ggccaatccc aagtctcgta ccaagggctt cctgtccaga agacccagac    840

catacattcc acatactccc accagcaggt cattcctcac gtctaccccg tggctgctaa    900

gacacagctt ggccggtgct tccaggaaac cattgggtca cagtgtggca aagcgctccc    960

tggcctttca aagcaagagg actgctgtgg aactgtgggt acctcctggg gctttaacaa   1020

atgccagaaa tgccccaaga aaccatctta tcatggatac aaccaaatga tggaatgcct   1080

accgggttat aagcgggtta acaacacctt ttgccaagat attaatgaat gtcagctaca   1140

aggtgtatgc cctaatggtg agtgtttgaa taccatgggc agctatcgat gtacctgcaa   1200

aataggattt gggccggatc ctaccttttc aagttgtgtt cctgatcccc ctgtgatctc   1260

ggaagagaaa gggccctgtt accgacttgt cagttctgga agacagtgta tgcaccctct   1320

gtctgttcac ctcaccaagc agctctgctg ttgtagtgtg ggcaaggcct ggggcccaca   1380

ctgtgagaaa tgtccccttc caggcacagc tgcttttaag gaaatctgtc ctggtggaat   1440

gggttatacg gtttctggcg ttcatagacg caggccaatc catcaccatg taggtaaagg   1500

acctgtattt gtcaagccaa agaacactca acctgttgct aaaagtactc atcctccacc   1560

tctcccagcc aaggaagagc cagtggaggc cctgaccttc tcccgggaac acgggccagg   1620

agtggcggag ccagaagtgg caactgcacc ccctgaaaag gaaatacctt cattggatca   1680

agagaaaacc aaacttgagc ctggtcaacc ccagctgtct ccaggcattt ccactattca   1740

tctgcatcca cagtttccag tagtgattga aaaaacatca cctcctgtgc ctgttgaagt   1800

agctcctgaa gcttctacgt ctagtgccag ccaagtgatt gctcctactc aagtgacaga   1860

aatcaatgaa tgtactgtga accctgatat ctgtggagca ggacactgca ttaacctacc   1920

agtgagatat acctgtatat gctacgaggg ctacaggttc agtgaacaac agaggaaatg   1980

tgtggatatt gatgagtgta ctcaggtcca acacctctgc tcccagggcc gctgtgaaaa   2040

caccgaggga agtttcttgt gcatttgccc agcaggattt atggccagtg aggagggtac   2100

taactgcata gatgttgacg aatgcctgag gccggacgtc tgtggggagg ggcactgtgt   2160

caatactgtg ggggccttcc ggtgtgaata ctgtgacagc gggtaccgca tgactcagag   2220

aggccgttgt gaggatattg atgaatgttt gaatccaagc acttgtccag atgagcagtg   2280

tgtgaattct cctggatctt accagtgcgt tccctgcaca gaaggattcc gaggctggaa   2340

tggacagtgc cttgatgtgg acgagtgcct ggaaccaaac gtctgcgcaa atggtgattg   2400

ttccaacctt gaaggctcct acatgtgttc atgccacaaa ggctataccc ggactccgga   2460

ccacaagcac tgtagagata ttgatgaatg tcagcaaggg aatctatgtg taaacgggca   2520

gtgcaaaaat accgagggct ccttcaggtg cacctgtgga caggggtacc agctgtcggc   2580

agctaaagac cagtgtgaag acattgatga atgccagcac cgtcatctct gtgctcatgg   2640

gcagtgcagg aacactgagg gctcttttca atgtgtgtgt gaccagggtt acagagcatc   2700

tgggcttgga gaccactgtg aagatatcaa tgaatgcttg gaggacaaga gtgtttgcca   2760

gagaggagac tgcattaata ctgcagggtc ctatgattgt acttgtccgg atggatttca   2820

gctagatgac aataaaacat gtcaagatat taatgaatgt gaacatccag ggctctgtgg   2880

tccgcaaggg gagtgcctaa acacagaggg ttctttccat tgtgtctgcc agcagggttt   2940

ctcaatctct gcagatggcc gtacgtgtga agatattgat gaatgtgtaa acaacactgt   3000

ttgtgacagt cacgggtttt gtgacaatac agctggctcc ttccgctgcc tctgttatca   3060

gggctttcaa gccccacagg atgggcaagg gtgtgtggat gtgaatgaat gtgaactgct   3120

cagtggggtg tgtggtgaag ccttctgtga aaacgtggaa gggtccttcc tgtgcgtgtg   3180

tgctgatgaa aaccaagagt acagccccat gactgggcag tgccgctccc ggacctccac   3240

agatttagat gtagatgtag atcaacccaa agaagaaaag aaagaatgct actataatct   3300

caatgacgcc agtctctgtg ataatgtgtt ggcccccaat gtcacgaaac aagaatgctg   3360

ctgtacatca ggcgtgggat ggggagataa ctgcgaaatc ttcccctgcc cggtcttggg   3420

aactgctgag ttcactgaaa tgtgtcccaa agggaaaggt tttgtgcctg ctggagaatc   3480

atcttctgaa gctggtggtg agaactataa agatgcagat gaatgcctac tttttggaca   3540

agaaatctgc aaaaatggtt tctgtttgaa cactcggcct gggtatgaat gctactgtaa   3600

gcaagggacg tactatgatc ctgtgaaact gcagtgcttt gatatggatg aatgtcaaga   3660

ccccagtagt tgtattgatg gccagtgtgt taatacagag ggctcttaca actgcttctg   3720

tactcacccc atggtcctgg atgcgtcaga aaaaagatgt atacgaccgg ctgagtcaaa   3780

cgaacaaata gaagaaactg atgtctacca agatttgtgc tgggaacatc tgagtgatga   3840

atacgtgtgt agccggcctc ttgtgggcaa gcagacaacg tacactgagt gctgctgtct   3900

gtatggagag gcctggggca tgcagtgtgc cctctgcccc ctgaaggatt cagatgacta   3960

tgctcagctg tgtaacatcc ccgtgacggg acgccggcag ccatatggac gggacgcctt   4020

ggttgacttc agtgaacagt atactccaga agccgatccc tacttcatcc aagaccgttt   4080

tctaaatagc tttgaggagt tacaggctga ggaatgcggc atcctcaatg gatgtgaaaa   4140

tggtcgctgt gtgagggtcc aggaaggtta cacctgcgat tgctttgatg ggtatcactt   4200

ggatacggcc aagatgacct gtgtcgatgt aaatgaatgc gatgagttga acaaccggat   4260

gtctctctgc aagaatgcca agtgcattaa caccgatggt tcctacaagt gtttgtgtct   4320

gccaggctac gtgccttctg acaagccaaa ctactgcact ccgttgaata ccgccttgaa   4380

tttagagaaa gacagtgacc tggagtgaaa cagaatctac ataacctaag cccatatact   4440

ctgcactgtg taaaggaaaa gggagaaatg tattatactt gagacattgc acctaccccg   4500

gaaggctgga aatacagaaa cagcatggaa ttgcaagtcc tctgaagaca atgagaggat   4560

ttaggatgag cccgataggt gtggcagacc aaatggacat ttctctaaaa aaccagtata   4620

tatagtctgt tcatatgtaa aattcaatgg aagagaggtg gaacagtgct gttattttaa   4680

acagaaggtt gtattattat gttgttttgt ttttttacta ttgcttgatt aaatttggca   4740

tttaaatagt ggtggaaata ttttatataa ttttcatttt ttggttgtgc agttccttgg   4800

ctactgtttt tcttttactt cagtttttta aaaatctcaa atgaaaaagt cttcgataca   4860

atattgttaa gctgtattat aagtattgtt acacagggtt atgcaattcc cggcctggag   4920

catttttgaa attcaaattg tctgtcctgt ggagcaggca gtgattttgt tccaaaactt   4980

tgtatacaca tttggagaaa agtactttat attttcagtg ttttgtctga ttttaatgtc   5040

cgttcttagc caagctgcta gcaggtgtta attggatccc tttccttcac tgaaatggaa   5100

gagtttataa gcttacgtta gtattgtaat atgtaaagta agcccaacaa aaatttttaa   5160

aaatttgatg atccccaata tatctaccat tgtatgttaa ataaatcacc atttttgtag   5220

aaaaaattct acctgagagt aattgtcaat gagtacatgt gtataagttg tatcccactc   5280

tccccacttt tatcttttcc agtggtcttc tgttaatgta gtgtctttta caagttaatc   5340

attaaatttg ttagatcttg ttatgggct                                     5369


<210>  7690
<211>  1395
<212>  PRT
<213>  Homosapiens

<400>  7690

Met Asp Thr Lys Leu Met Cys Leu Leu Phe Phe Phe Ser Leu Pro Pro 
1               5                   10                  15      


Leu Leu Val Ser Asn His Thr Gly Arg Ile Lys Val Val Phe Thr Pro 
            20                  25                  30          


Ser Ile Cys Lys Val Thr Cys Thr Lys Gly Ser Cys Gln Asn Ser Cys 
        35                  40                  45              


Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser Glu Asn Gly His Ala Ala 
    50                  55                  60                  


Asp Thr Leu Thr Ala Thr Asn Phe Arg Val Val Ile Cys His Leu Pro 
65                  70                  75                  80  


Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asp Lys Cys Gln Cys Pro 
                85                  90                  95      


Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile Pro Val His Gly Ala Ser 
            100                 105                 110         


Val Pro Lys Leu Tyr Gln His Ser Gln Gln Pro Gly Lys Ala Leu Gly 
        115                 120                 125             


Thr His Val Ile His Ser Thr His Thr Leu Pro Leu Thr Val Thr Ser 
    130                 135                 140                 


Gln Gln Gly Val Lys Val Lys Phe Pro Pro Asn Ile Val Asn Ile His 
145                 150                 155                 160 


Val Lys His Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ser Arg 
                165                 170                 175     


Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys Glu Ala Gln Pro Gly Gln 
            180                 185                 190         


Ser Gln Val Ser Tyr Gln Gly Leu Pro Val Gln Lys Thr Gln Thr Ile 
        195                 200                 205             


His Ser Thr Tyr Ser His Gln Gln Val Ile Pro His Val Tyr Pro Val 
    210                 215                 220                 


Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe Gln Glu Thr Ile Gly Ser 
225                 230                 235                 240 


Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser Lys Gln Glu Asp Cys Cys 
                245                 250                 255     


Gly Thr Val Gly Thr Ser Trp Gly Phe Asn Lys Cys Gln Lys Cys Pro 
            260                 265                 270         


Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln Met Met Glu Cys Leu Pro 
        275                 280                 285             


Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys Gln Asp Ile Asn Glu Cys 
    290                 295                 300                 


Gln Leu Gln Gly Val Cys Pro Asn Gly Glu Cys Leu Asn Thr Met Gly 
305                 310                 315                 320 


Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe Gly Pro Asp Pro Thr Phe 
                325                 330                 335     


Ser Ser Cys Val Pro Asp Pro Pro Val Ile Ser Glu Glu Lys Gly Pro 
            340                 345                 350         


Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln Cys Met His Pro Leu Ser 
        355                 360                 365             


Val His Leu Thr Lys Gln Leu Cys Cys Cys Ser Val Gly Lys Ala Trp 
    370                 375                 380                 


Gly Pro His Cys Glu Lys Cys Pro Leu Pro Gly Thr Ala Ala Phe Lys 
385                 390                 395                 400 


Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr Val Ser Gly Val His Arg 
                405                 410                 415     


Arg Arg Pro Ile His His His Val Gly Lys Gly Pro Val Phe Val Lys 
            420                 425                 430         


Pro Lys Asn Thr Gln Pro Val Ala Lys Ser Thr His Pro Pro Pro Leu 
        435                 440                 445             


Pro Ala Lys Glu Glu Pro Val Glu Ala Leu Thr Phe Ser Arg Glu His 
    450                 455                 460                 


Gly Pro Gly Val Ala Glu Pro Glu Val Ala Thr Ala Pro Pro Glu Lys 
465                 470                 475                 480 


Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr Lys Leu Glu Pro Gly Gln 
                485                 490                 495     


Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile His Leu His Pro Gln Phe 
            500                 505                 510         


Pro Val Val Ile Glu Lys Thr Ser Pro Pro Val Pro Val Glu Val Ala 
        515                 520                 525             


Pro Glu Ala Ser Thr Ser Ser Ala Ser Gln Val Ile Ala Pro Thr Gln 
    530                 535                 540                 


Val Thr Glu Ile Asn Glu Cys Thr Val Asn Pro Asp Ile Cys Gly Ala 
545                 550                 555                 560 


Gly His Cys Ile Asn Leu Pro Val Arg Tyr Thr Cys Ile Cys Tyr Glu 
                565                 570                 575     


Gly Tyr Arg Phe Ser Glu Gln Gln Arg Lys Cys Val Asp Ile Asp Glu 
            580                 585                 590         


Cys Thr Gln Val Gln His Leu Cys Ser Gln Gly Arg Cys Glu Asn Thr 
        595                 600                 605             


Glu Gly Ser Phe Leu Cys Ile Cys Pro Ala Gly Phe Met Ala Ser Glu 
    610                 615                 620                 


Glu Gly Thr Asn Cys Ile Asp Val Asp Glu Cys Leu Arg Pro Asp Val 
625                 630                 635                 640 


Cys Gly Glu Gly His Cys Val Asn Thr Val Gly Ala Phe Arg Cys Glu 
                645                 650                 655     


Tyr Cys Asp Ser Gly Tyr Arg Met Thr Gln Arg Gly Arg Cys Glu Asp 
            660                 665                 670         


Ile Asp Glu Cys Leu Asn Pro Ser Thr Cys Pro Asp Glu Gln Cys Val 
        675                 680                 685             


Asn Ser Pro Gly Ser Tyr Gln Cys Val Pro Cys Thr Glu Gly Phe Arg 
    690                 695                 700                 


Gly Trp Asn Gly Gln Cys Leu Asp Val Asp Glu Cys Leu Glu Pro Asn 
705                 710                 715                 720 


Val Cys Ala Asn Gly Asp Cys Ser Asn Leu Glu Gly Ser Tyr Met Cys 
                725                 730                 735     


Ser Cys His Lys Gly Tyr Thr Arg Thr Pro Asp His Lys His Cys Arg 
            740                 745                 750         


Asp Ile Asp Glu Cys Gln Gln Gly Asn Leu Cys Val Asn Gly Gln Cys 
        755                 760                 765             


Lys Asn Thr Glu Gly Ser Phe Arg Cys Thr Cys Gly Gln Gly Tyr Gln 
    770                 775                 780                 


Leu Ser Ala Ala Lys Asp Gln Cys Glu Asp Ile Asp Glu Cys Gln His 
785                 790                 795                 800 


Arg His Leu Cys Ala His Gly Gln Cys Arg Asn Thr Glu Gly Ser Phe 
                805                 810                 815     


Gln Cys Val Cys Asp Gln Gly Tyr Arg Ala Ser Gly Leu Gly Asp His 
            820                 825                 830         


Cys Glu Asp Ile Asn Glu Cys Leu Glu Asp Lys Ser Val Cys Gln Arg 
        835                 840                 845             


Gly Asp Cys Ile Asn Thr Ala Gly Ser Tyr Asp Cys Thr Cys Pro Asp 
    850                 855                 860                 


Gly Phe Gln Leu Asp Asp Asn Lys Thr Cys Gln Asp Ile Asn Glu Cys 
865                 870                 875                 880 


Glu His Pro Gly Leu Cys Gly Pro Gln Gly Glu Cys Leu Asn Thr Glu 
                885                 890                 895     


Gly Ser Phe His Cys Val Cys Gln Gln Gly Phe Ser Ile Ser Ala Asp 
            900                 905                 910         


Gly Arg Thr Cys Glu Asp Ile Asp Glu Cys Val Asn Asn Thr Val Cys 
        915                 920                 925             


Asp Ser His Gly Phe Cys Asp Asn Thr Ala Gly Ser Phe Arg Cys Leu 
    930                 935                 940                 


Cys Tyr Gln Gly Phe Gln Ala Pro Gln Asp Gly Gln Gly Cys Val Asp 
945                 950                 955                 960 


Val Asn Glu Cys Glu Leu Leu Ser Gly Val Cys Gly Glu Ala Phe Cys 
                965                 970                 975     


Glu Asn Val Glu Gly Ser Phe Leu Cys Val Cys Ala Asp Glu Asn Gln 
            980                 985                 990         


Glu Tyr Ser Pro Met Thr Gly Gln  Cys Arg Ser Arg Thr  Ser Thr Asp 
        995                 1000                 1005             


Leu Asp  Val Asp Val Asp Gln  Pro Lys Glu Glu Lys  Lys Glu Cys 
    1010                 1015                 1020             


Tyr Tyr  Asn Leu Asn Asp Ala  Ser Leu Cys Asp Asn  Val Leu Ala 
    1025                 1030                 1035             


Pro Asn  Val Thr Lys Gln Glu  Cys Cys Cys Thr Ser  Gly Val Gly 
    1040                 1045                 1050             


Trp Gly  Asp Asn Cys Glu Ile  Phe Pro Cys Pro Val  Leu Gly Thr 
    1055                 1060                 1065             


Ala Glu  Phe Thr Glu Met Cys  Pro Lys Gly Lys Gly  Phe Val Pro 
    1070                 1075                 1080             


Ala Gly  Glu Ser Ser Ser Glu  Ala Gly Gly Glu Asn  Tyr Lys Asp 
    1085                 1090                 1095             


Ala Asp  Glu Cys Leu Leu Phe  Gly Gln Glu Ile Cys  Lys Asn Gly 
    1100                 1105                 1110             


Phe Cys  Leu Asn Thr Arg Pro  Gly Tyr Glu Cys Tyr  Cys Lys Gln 
    1115                 1120                 1125             


Gly Thr  Tyr Tyr Asp Pro Val  Lys Leu Gln Cys Phe  Asp Met Asp 
    1130                 1135                 1140             


Glu Cys  Gln Asp Pro Ser Ser  Cys Ile Asp Gly Gln  Cys Val Asn 
    1145                 1150                 1155             


Thr Glu  Gly Ser Tyr Asn Cys  Phe Cys Thr His Pro  Met Val Leu 
    1160                 1165                 1170             


Asp Ala  Ser Glu Lys Arg Cys  Ile Arg Pro Ala Glu  Ser Asn Glu 
    1175                 1180                 1185             


Gln Ile  Glu Glu Thr Asp Val  Tyr Gln Asp Leu Cys  Trp Glu His 
    1190                 1195                 1200             


Leu Ser  Asp Glu Tyr Val Cys  Ser Arg Pro Leu Val  Gly Lys Gln 
    1205                 1210                 1215             


Thr Thr  Tyr Thr Glu Cys Cys  Cys Leu Tyr Gly Glu  Ala Trp Gly 
    1220                 1225                 1230             


Met Gln  Cys Ala Leu Cys Pro  Leu Lys Asp Ser Asp  Asp Tyr Ala 
    1235                 1240                 1245             


Gln Leu  Cys Asn Ile Pro Val  Thr Gly Arg Arg Gln  Pro Tyr Gly 
    1250                 1255                 1260             


Arg Asp  Ala Leu Val Asp Phe  Ser Glu Gln Tyr Thr  Pro Glu Ala 
    1265                 1270                 1275             


Asp Pro  Tyr Phe Ile Gln Asp  Arg Phe Leu Asn Ser  Phe Glu Glu 
    1280                 1285                 1290             


Leu Gln  Ala Glu Glu Cys Gly  Ile Leu Asn Gly Cys  Glu Asn Gly 
    1295                 1300                 1305             


Arg Cys  Val Arg Val Gln Glu  Gly Tyr Thr Cys Asp  Cys Phe Asp 
    1310                 1315                 1320             


Gly Tyr  His Leu Asp Thr Ala  Lys Met Thr Cys Val  Asp Val Asn 
    1325                 1330                 1335             


Glu Cys  Asp Glu Leu Asn Asn  Arg Met Ser Leu Cys  Lys Asn Ala 
    1340                 1345                 1350             


Lys Cys  Ile Asn Thr Asp Gly  Ser Tyr Lys Cys Leu  Cys Leu Pro 
    1355                 1360                 1365             


Gly Tyr  Val Pro Ser Asp Lys  Pro Asn Tyr Cys Thr  Pro Leu Asn 
    1370                 1375                 1380             


Thr Ala  Leu Asn Leu Glu Lys  Asp Ser Asp Leu Glu  
    1385                 1390                 1395 


<210>  7691
<211>  621
<212>  DNA
<213>  Homosapiens

<400>  7691
gcgggtggcg gcgaacgcgg agagcacgcc atgaaggcct cgggcacact acgagagtac     60

aaagtagtgg gtcgctgcct gcccaccccc aaatgccaca caccacccct ctaccgcatg    120

cgaatctttg cgcctaatca tgtcgtcgcc aagtcccgct tctggtactt cgtatctcag    180

ttaaagaaga tgaagaagtc ttcaggggag attgtctact gtgggcaggt gtttgagaag    240

ttccccttgc gggtgaagaa cttcgggatc tggctgcgct atgactcccg gagcggcacc    300

cacaacatgt accgggaata ccgggacctg accaccgcag gcgctgtcac ccggtgctac    360

cgagacatga gcgcccggca cggcggccgg gcccactcca ttcagatcat gaaggtggag    420

gagatcgcgg ccagcaagtg ccgccggccg gctgtcaagc agttccacga ctccaagatc    480

aagttcccgc tgccccaccg ggtcctgcgc cgtcagcaca agccacgctt caccaccaag    540

aggcccaaca ccttcttcta ggtgcagggc cctcgcccgg gtgtgcccca aataaactca    600

ggaacgcccc agaaaaaaaa a                                              621


<210>  7692
<211>  176
<212>  PRT
<213>  Homosapiens

<400>  7692

Met Lys Ala Ser Gly Thr Leu Arg Glu Tyr Lys Val Val Gly Arg Cys 
1               5                   10                  15      


Leu Pro Thr Pro Lys Cys His Thr Pro Pro Leu Tyr Arg Met Arg Ile 
            20                  25                  30          


Phe Ala Pro Asn His Val Val Ala Lys Ser Arg Phe Trp Tyr Phe Val 
        35                  40                  45              


Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys 
    50                  55                  60                  


Gly Gln Val Phe Glu Lys Phe Pro Leu Arg Val Lys Asn Phe Gly Ile 
65                  70                  75                  80  


Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr His Asn Met Tyr Arg Glu 
                85                  90                  95      


Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Arg Cys Tyr Arg Asp 
            100                 105                 110         


Met Ser Ala Arg His Gly Gly Arg Ala His Ser Ile Gln Ile Met Lys 
        115                 120                 125             


Val Glu Glu Ile Ala Ala Ser Lys Cys Arg Arg Pro Ala Val Lys Gln 
    130                 135                 140                 


Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His Arg Val Leu Arg 
145                 150                 155                 160 


Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro Asn Thr Phe Phe 
                165                 170                 175     


<210>  7693
<211>  2211
<212>  DNA
<213>  Homosapiens

<400>  7693
gtgggcatgt cttagggaag cccctctgta tgagttccct tatctgtgcc tgcagcatgc     60

agcatgattt tttttttttt tttttttttt gagacagagt ctcactctgt cgcccaggct    120

ggagtgcagt ggcgtggtct cggctcaccg caaactccgc ctcctgggtt cacaccattc    180

tcctgcctca atctcccaag tagctgggac tacaggcacc caccaccacg cccagctaat    240

tttttttttt tttgtatttt ttagtagaga tggggtttcg ccatgttagc caggatggtc    300

tggatctcct gacctcgtga tccgcccgcc tgtgcctccc aaagtgttgg gattacaggc    360

gtgagccact gtgcccagcc tccagcatga tttttttagg ccgttctttt gtttgaaaga    420

attcaactaa ggatccactc tgcctgcctg accggtttct tcctttcttc tctctcatcg    480

ggtcccgagt tcccatgact gcagcttcca gaagagcaga gctttggtat cctactcaca    540

gcgccaaaac tgcaggggcc aaggaaagat acaaaattct tgtgtgcagc ctcttttgga    600

ctccagctct tgttctctcg ctgaatccca ccgccacccc ttcaagtcat cggctgtgat    660

tcacctgtgg gtttctgaag gctagaagct tccacaatga gccaggaaac aagttctgat    720

tggctgggaa cagacctctg ctccaagatt cagggctggc agtattcctt ctgttctggt    780

ggctcgatct tcattgcttt cctctggact tgtaagttat tccaacaaac cccagctgct    840

ctgcagtgaa atgttccaaa taattaatat ttctgcagga attaccttgt aaaagatatg    900

tgcttttaag tatttggtta ttgtgcaaat gtttttgact accttttgtg gccaattttc    960

tccttcagcg ggctcatgta taattttaga taaaagtaca aggaaattat gattccataa   1020

tcataagtct actttcagca atacacgtat cttcagagaa tctcagcctc cctgcagcat   1080

cctcctggtg cacagaaaaa ctgctgaatt ctggcaagat actcaaagga ttctgacggg   1140

tgaccatctc aggccggaga tatgcccaac caactggaaa agcagagaca gccatggaca   1200

gatctgctga cgctaaagtt tatagacagc tgaggtgcaa cccatataat cacccagatg   1260

ttattaggcc atgatcattc tgtagtaagc tacctccctt ctgtgtttcc tctcacctga   1320

cagcctattg tgggcacttt caaggcccca ctgtgtccaa atcacaccac caccaaagct   1380

cacagaagca cgctggtaga tttctcctct ttggtggttt cccatgacca gccaagggaa   1440

atacccaaca atcattctca gtgtgcacag atttaccttc agcttttttg gttatattgt   1500

cattattatt ttctttgtcc agtgggagag ttaaggggcc tgctatggac tgaactctgt   1560

ccccctcaaa ttcatatgtt gaagccccaa ccttcaacat gactatattt gaaaacagtc   1620

cctttatgga ggtaaagtta aatgagatca taagagtggg gcccttgttc gatagaactg   1680

gtgtccttac aagaagagga agaggctgag tgcagtggct caagcctata atcccagcac   1740

tttgggaagc tgaggcagga ggtacgcttg ggcccaggag ttcaagacca gcttgggcaa   1800

cataacaaga ccctatctct acagaaaaaa attaaaaatt aaccaggtgt gatggcatgt   1860

gcttgtggta ccagctactc aggaggctga gatgggtgga tggcttgagc ctgggaggtc   1920

aaggttgcag tgagctgtga tagcactgca ctccagcctg ggtaacagag caagaccctg   1980

tccctcccca caccacccca actcccccca aaaaggaaga gataccagag tgcactctct   2040

cgatctctct ctctctcttc cacgtgagga cacagaagaa aaaaaaaaaa gcccatctgc   2100

aaggcaggaa gacggccttc aacagcaacg aaatcagtca gcaccttggt ttggactgct   2160

tggtctccag aacgagggaa aataaattaa aataaatgtc tgtagaatta a            2211


<210>  7694
<211>  54
<212>  PRT
<213>  Homosapiens

<400>  7694

Met Thr Ala Ala Ser Arg Arg Ala Glu Leu Trp Tyr Pro Thr His Ser 
1               5                   10                  15      


Ala Lys Thr Ala Gly Ala Lys Glu Arg Tyr Lys Ile Leu Val Cys Ser 
            20                  25                  30          


Leu Phe Trp Thr Pro Ala Leu Val Leu Ser Leu Asn Pro Thr Ala Thr 
        35                  40                  45              


Pro Ser Ser His Arg Leu 
    50                  


<210>  7695
<211>  802
<212>  DNA
<213>  Homosapiens

<400>  7695
agagatgggg tttcgccatg ttagccagga tggtctggat ctcctgacct cgtgatccgc     60

ccgcctgtgc ctcccaaagt gttgggatta caggcgtgag ccactgtgcc cagcctccag    120

catgattttt ttaggccgtt cttttgtttg aaagaattca actaaggatc cactctgcct    180

gcctgaccgg tttcttcctt tcttctctct catcgggtcc cgagttccca tgactgcagc    240

ttccagaaga gcagagcttt ggtatcctac tcacagcgcc aaaactgcag gggccaagaa    300

acaccctgtt gcccaggctg gagtgcagtg atgcaatcat agctcacaat ggcctcgaac    360

tcctgggctc aagccatcct cccgtgtcag actcccaagt agctgggatt acagagacgg    420

agtcttgctc tgtcacccag gctggagtgc agtggtgcga tcgcagctct ctgtaacctc    480

tgtctccctg gttcaagtga ttcttctgcc tcagcctccc aagtagctgg gattacagaa    540

actcctccta cccatggaat ctgccagcag ttggattctt gactatcttt aggacttttc    600

ctaatctcac cttctccatc tgtgaaatgg aaataatcaa aggctcaaca atccttctgt    660

gaaagaggca tattttgtgg tgctatgtgc tgatcttcca cacagccaaa tggaggcaga    720

ggtcacagag gaactagaag gatggaaaac tgcaggagag tctcgttgcc atcactcagt    780

caatcaacca gttttggata cc                                             802


<210>  7696
<211>  33
<212>  PRT
<213>  Homosapiens

<400>  7696

Met Thr Ala Ala Ser Arg Arg Ala Glu Leu Trp Tyr Pro Thr His Ser 
1               5                   10                  15      


Ala Lys Thr Ala Gly Ala Lys Lys His Pro Val Ala Gln Ala Gly Val 
            20                  25                  30          


Gln 
    


<210>  7697
<211>  2010
<212>  DNA
<213>  Homosapiens

<400>  7697
ggatctcctg acctcgtgat ccgcccgcct gtgcctccca aagtgttggg attacaggcg     60

tgagccactg tgcccagcct ccagcatgat ttttttaggc cgttcttttg tttgaaagaa    120

ttcaactaag gatccactct gcctgcctga ccggtttctt cctttcttct ctctcatcgg    180

gtcccgagtt cccatgactg cagcttccag aagagcagag ctttggtatc ctactcacag    240

cgccaaaact gcaggggcca agatgcaaat cttccgcaca aaagacagct ttgcagggct    300

gcttctgttt gcaggccctc tgaacagcca tctcaaaaca tgtcaaagaa gtatatcttg    360

gggaaagata caaaattctt gtgtgcagcc tcttttggac tccagctctt gttctctcgc    420

tgaatcccac cgccacccct tcaagtcatc ggctgtgatt cacctgtggg tttctgaagg    480

ctagaagctt ccacaatgag ccaggaaaca agttctgatt ggctgggaac agacctctgc    540

tccaagattc agggctggca gtattccttc tgttctggtg gctcgatctt cattgctttc    600

ctctggactt gtaagttatt ccaacaaacc ccagctgctc tgcagtgaaa tgttccaaat    660

aattaatatt tctgcaggaa ttaccttgta aaagatatgt gcttttaagt atttggttat    720

tgtgcaaatg tttttgacta ccttttgtgg ccaattttct ccttcagcgg gctcatgtat    780

aattttagat aaaagtacaa ggaaattatg attccataat cataagtcta ctttcagcaa    840

tacacgtatc ttcagagaat ctcagcctcc ctgcagcatc ctcctggtgc acagaaaaac    900

tgctgaattc tggcaagata ctcaaaggat tctgacgggt gaccatctca ggccggagat    960

atgcccaacc aactggaaaa gcagagacag ccatggacag atctgctgac gctaaagttt   1020

atagacagct gaggtgcaac ccatataatc acccagatgt tattaggcca tgatcattct   1080

gtagtaagct acctcccttc tgtgtttcct ctcacctgac agcctattgt gggcactttc   1140

aaggccccac tgtgtccaaa tcacaccacc accaaagctc acagaagcac gctggtagat   1200

ttctcctctt tggtggtttc ccatgaccag ccaagggaaa tacccaacaa tcattctcag   1260

tgtgcacaga tttaccttca gcttttttgg ttatattgtc attattattt tctttgtcca   1320

gtgggagagt taaggggcct gctatggact gaactctgtc cccctcaaat tcatatgttg   1380

aagccccaac cttcaacatg actatatttg aaaacagtcc ctttatggag gtaaagttaa   1440

atgagatcat aagagtgggg cccttgttcg atagaactgg tgtccttaca agaagaggaa   1500

gaggctgagt gcagtggctc aagcctataa tcccagcact ttgggaagct gaggcaggag   1560

gtacgcttgg gcccaggagt tcaagaccag cttgggcaac ataacaagac cctatctcta   1620

cagaaaaaaa ttaaaaatta accaggtgtg atggcatgtg cttgtggtac cagctactca   1680

ggaggctgag atgggtggat ggcttgagcc tgggaggtca aggttgcagt gagctgtgat   1740

agcactgcac tccagcctgg gtaacagagc aagaccctgt ccctccccac accaccccaa   1800

ctccccccaa aaaggaagag ataccagagt gcactctctc gatctctctc tctctcttcc   1860

acgtgaggac acagaagaaa aaaaaaaaag cccatctgca aggcaggaag acggccttca   1920

acagcaacga aatcagtcag caccttggtt tggactgctt ggtctccaga acgagggaaa   1980

ataaattaaa ataaatgtct gtagaattaa                                    2010


<210>  7698
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  7698

Met Thr Ala Ala Ser Arg Arg Ala Glu Leu Trp Tyr Pro Thr His Ser 
1               5                   10                  15      


Ala Lys Thr Ala Gly Ala Lys Met Gln Ile Phe Arg Thr Lys Asp Ser 
            20                  25                  30          


Phe Ala Gly Leu Leu Leu Phe Ala Gly Pro Leu Asn Ser His Leu Lys 
        35                  40                  45              


Thr Cys Gln Arg Ser Ile Ser Trp Gly Lys Ile Gln Asn Ser Cys Val 
    50                  55                  60                  


Gln Pro Leu Leu Asp Ser Ser Ser Cys Ser Leu Ala Glu Ser His Arg 
65                  70                  75                  80  


His Pro Phe Lys Ser Ser Ala Val Ile His Leu Trp Val Ser Glu Gly 
                85                  90                  95      


<210>  7699
<211>  540
<212>  DNA
<213>  Homosapiens

<400>  7699
attacttttc cagctcgaat gaggtataat tgacaaataa aagttgtatt catttaagat     60

atacaagttt atgatctgat atacatgtac attgtgaaat aatcaccaca atcaagctaa    120

ttcaagctaa ttaacatata cattacttca catcattgca attctcttct tgttcttgtt    180

gttcttctct gtgtgtgtgt cttactattg gacaggggaa aaattcaaaa ctaagtgcag    240

ggaagtcgag ctcaaatgaa gggatcagtg gttttacaat aaacctggaa ttagcaggaa    300

aggttggagt aaataagtgt aaaatgtgta gcagttcctc ttgcaaatca tgctctgcac    360

attctgcaca tgtatcccag aaccttctgg ttcaatgttg acatggataa cggcttccac    420

taacttttcc ttgaacctgt ggtcaggcca ctgcactgca tcccaggtgg cagagggaga    480

ccagcaggtt tgtgaagaga ggcacaagga cataaacagc tcaggatggg tatcaagcaa    540


<210>  7700
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  7700

Met Leu Cys Thr Phe Cys Thr Cys Ile Pro Glu Pro Ser Gly Ser Met 
1               5                   10                  15      


Leu Thr Trp Ile Thr Ala Ser Thr Asn Phe Ser Leu Asn Leu Trp Ser 
            20                  25                  30          


Gly His Cys Thr Ala Ser Gln Val Ala Glu Gly Asp Gln Gln Val Cys 
        35                  40                  45              


Glu Glu Arg His Lys Asp Ile Asn Ser Ser Gly Trp Val Ser 
    50                  55                  60          


<210>  7701
<211>  2183
<212>  DNA
<213>  Homosapiens

<400>  7701
agaatgtctc tgaaatgaga tgagtggaaa atgccttaaa caggtggatg tggaacaggt     60

cggggacttt aaggacttca gtggaggagg ggtgggttgg ggaagggaaa caaatgaaga    120

tgtcttagaa gtcactgcaa tttatatgga atctgttcaa cgccgacact gaaccatatg    180

agaagacgtt tgaaactatt gctttgctga aaacatctga ctgccaggct aggatgtgac    240

acttaaggga cttaccaatt tgggattctt ccaggagctg aaaactgatt gcaaatatga    300

aacagatttc actacaggac ttgaacccta cattaaaaaa caacaagctc cccaaaataa    360

ttgaaaaaga tcttcaccaa agagtagctg caatgtgaat ggcaggatat gaagcaagta    420

agagagctat cactgccaaa ggctactgac taatggtgaa aagattatct taagcttgga    480

attaagtgat gaaagggacc ttcgaaatta tcaactctaa atacttcttt acaggaaaat    540

tgaaagcagt taagaacctg ccccctaccg tggagttctt ggtgccgtga gttggagttc    600

ttggtgcctg ggtgcgtccc caaggccact ggtcttcaga tctttcttac ttgagaagaa    660

cgcctccgcc tcctggctct cccaccagtg gtattgccac caccacacac cagcataaag    720

cacagattgc tgcccagctc cttggagagg ggccagtgca tttgtcagga attgaaaagt    780

tttggagcca gttcgaggac tttctcctgc acaaagtgtt ggctggaagc atgattatct    840

cacacagagc gttggaatta cttcatgatg atttcaaaga aaattttctt ctctaaacac    900

tcttatccca agggcatcct aaagttcctc tggaatgcat tgggtgggag agaaagttct    960

atgtcaactc ttctggcaga gggaaaagct gaccgaggaa gtcaaaatga aagaaagaag   1020

cagacaggac tgaggctccc tgagatgcag aaactgaggc acagagcaag gggctaggat   1080

tcttgacttt cttctgcaga acactgaaac atgcctcctc tttcctggcc ccaccaagca   1140

gagtttaggc ttcaagaaga ctgaatgcat ctgtacagag cacaatccct tctccaagaa   1200

ggaaaccatg gggcttatca agaaaggcgt acactgaaga gactggaaag tgaagatgca   1260

ctatttgtca agatgtgcca cagcagaagc aagttgtgtt ggcagtagga aacaagataa   1320

agagaagaac tcaaagaatt gagagaaggc tttgaacatg atgatggaga aataacactc   1380

ttgggagaaa tgaagatact ttctcctccc tggtttacct gagtttccag cacccagtga   1440

taagaaagga tggcattagt gatgtgtaca cctgcagtga tagcttcacc tttctaaagc   1500

agatgccgtg gtagacattt tgccagccct cctttcacta tacacacagc ttggtgtacg   1560

ctggcagact tttgacctaa tttcttaacc ctcaaatatt ccaagacaga acaaagcaca   1620

caacaaaacc agaatgaggc cgggcaaagt ggctcatgcc cgtaatccca gcactttggg   1680

aggctaaggg gtgggcagat cacttgaggt caggagtttg agaccagcct aggcaacatg   1740

gtgaaaccca gtctctactg aaaatacaaa aatcagccgg gtgtggtggc aaatgcctgt   1800

aatcccagct actggggagg ctgagacaca agaatcactt gaacccagga gggggagttt   1860

gcagtgagcc gagattgtgc cactgcatgc cagtctgaac aacagagcaa gactctgtca   1920

caaaaacaaa caaaaaactg aatgaatgga agcagataag tgcagagaga aacactgatt   1980

taccttcaga aagataaaaa agtagtatat tgatatactt gtatattgct atctactagt   2040

atagcttcag ttggtgtatg agtatagaac tattgggttg ttctttatgt gattactcct   2100

tcccagtttt agtaaagtat tccaatttga gggaaattct ttcatttgtc aataaaataa   2160

aaagaggtaa gttttaaaat ctg                                           2183


<210>  7702
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  7702

Met Met Ile Ser Lys Lys Ile Phe Phe Ser Lys His Ser Tyr Pro Lys 
1               5                   10                  15      


Gly Ile Leu Lys Phe Leu Trp Asn Ala Leu Gly Gly Arg Glu Ser Ser 
            20                  25                  30          


Met Ser Thr Leu Leu Ala Glu Gly Lys Ala Asp Arg Gly Ser Gln Asn 
        35                  40                  45              


Glu Arg Lys Lys Gln Thr Gly Leu Arg Leu Pro Glu Met Gln Lys Leu 
    50                  55                  60                  


Arg His Arg Ala Arg Gly 
65                  70  


<210>  7703
<211>  3861
<212>  DNA
<213>  Homosapiens

<400>  7703
atgtatgaaa gctttgacca gttcatctgg tcagatgtac gaaccagttg ccgtcttcaa     60

tgtttgcgtg tcacagctgt gaccattgta actaatagca atgttgcagg aaaattgaaa    120

gcagttaaga acctgccccc taccgtggag ttcttggtgc ctggtattgc caccaccaca    180

caccagcata aagcacagat tgctgcccag ctccttggag aggggccagt gcatttgtca    240

ggaattgaaa agttttggag ccagttcgag gactttctcc tgcacaaagt gttggctgga    300

agcatggttg atacattgat gagctacgaa aagcaagagg gaacatgccc atctactaag    360

aggagaagag agcctaaaac atacacattc actaaggaag agaaagccaa atgtgaggta    420

acagacactc acagggctac acctacaact ggtcaattta aaaatgttaa aactaaactt    480

ggcagcagat atcatccttc taccacctct atgcttgtgc ccttcagctt cctcctttgt    540

cttcatgcct ctagaaggac agtgactatg tctcctaaag acagcactga ttatcacaca    600

ttatctcaca cagagcgttg gaattacttc atgatgattt caaagaaaat tttcttctct    660

aaacactctt atcccaaggg catcctaaag ttcctctgga atgcattggg tgggagagaa    720

agttctatgt caactcttct ggcagaggga aaagctgacc gaggaagtca aaatgaaaga    780

aagaagcaga caggactgag gctccctgag atgcagaaac tgaggcacag agcaaggatg    840

tgccacagca gaagcaagtt gtgttggcag taggaaacaa gataaagaga agaactcaaa    900

gaattgagag aaggctttga acatgatgat ggagaaataa cactcttggg agaaatgaag    960

atactttctc ctccctggtt tacctgagtt tccagcaccc agtgataaga aaggatggca   1020

ttagtgatgt gtacacctgc agtgatagct tcacctttct aaagcagatg ccgtggtaga   1080

cattttgcca gccctccttt cactatacac acagcttggt gtacgctggc agacttttga   1140

cctaatttct taaccctcaa atattccaag acagaacaaa gcacacaaca aaaccagaat   1200

gaggccgggc aaagtggctc atgcccgtaa tcccagcact ttgggaggct aaggggtggg   1260

cagatcactt gaggtcagga gtttgagacc agcctaggca acatggtgaa acccagtctc   1320

tactgaaaat acaaaaatca gccgggtgtg gtggcaaatg cctgtaatcc cagctactgg   1380

ggaggctgag acacaagaat cacttgaacc caggaggggg agtttgcagt gagccgagat   1440

tgtgccactg catgccagtc tgaacaacag agcaagactc tgtcacaaaa acaaacaaaa   1500

aactgaatga atggaagcag ataagtgcag agagaaacac tgatttacct tcagaaagat   1560

aaaaaagtag tatattgata tacttgtata ttgctatcta ctagtatagc ttcagttggt   1620

gtatgagtat agaactattg ggttgttctt tatgtgatta ctccttccca gttttagtaa   1680

agtattccaa tttgagggaa attctttcat ttgtcaataa aataaaaaga ggtaagtttt   1740

aaaatctgta tagttcttcc ttcatgctag ttgcctctct ttttgatatt tcttctataa   1800

aaatcttttc ttacattcag ttttcattgt atagatcatg aaggaaccat agtgattatc   1860

aaagatcagc cgataagttc aaggcagagt tccacctttc cccatgaagc ccttccagac   1920

ttgtttacat gtaacaccct tgaaggcaag actcatgtct atgctatctt tgctgctatt   1980

tggcacgtat taggtgtaag ggcaattaga ccatatcaat taatgatcag taagaatgga   2040

taaagtagat gtttttgtga gcctctcaaa gaagatgtat agaatatttt ggaaatgggc   2100

ccaatttgtt tctaaaggaa aatttacttt caaattaaaa aaaaaaaatc actcaaatga   2160

gattttgggg gatttcatat gattaactct ttacattatc ttgtggtaat tatacagaaa   2220

tctgtattta tgtaaacaca gtaaatgcat cataacacta gaataagtat acaaatactg   2280

catgtcaaat taggttataa tcactttcaa gggacgtgat ttcctagcta aacagattcg   2340

tttacatttt gcaaaataaa aaataagtga aaataactat ataaaatcag gcttacagct   2400

ggacagatct tcttggcaat ggtccagaca ctgagtaggg aaaagcccct ccagctgagg   2460

aacgttcagg acgctcagga cgactttgca ggcgcggccg ggagagaggc catttttggg   2520

gttgccttga ctgtgcaccc tgttcctggc tacctatggg gagataagct gcattcacat   2580

atcagatgag actctttttg tgagaggtct ggggtgggat gtgggaagtg gagtgaaaac   2640

ctgcttagta ggggaggaaa aaaacaagca atccaacact tcacctttag gtaataaaca   2700

taatagaaaa agtcaggaat tctctaacta aaaagcagac agtggaagct agcatcggac   2760

tcactgaatt ttagaatcag ggtctgtgta ccatggatta tctggccctg cccttgtcac   2820

tggatgagaa gattctggct atagggcaag aagcagtgct tggaccgaga tccagaatgt   2880

taccctcaaa tctgaagctt atttatgaga taaataaagc tcatattttc aagagagata   2940

attattttaa aacttctcat ttcaatgtgt accttaaaaa aataaataca ttttgggcca   3000

ggtgcgatgg ttcatgcctg taatcccagc actttgggag gccgaggtgg gcagatcatg   3060

aggtcagttt gagaccagcc tggccaacat agtgaaactc cgtctctact aaaaataaaa   3120

ataaaaaaat tagctgggca tagtggcacg tacctgtagt cccagctact taggaggctg   3180

aagcaggaga atcgcttgaa cccatgaggc agaggttgtg gtgagcccaa attgcgccac   3240

tgcactccag cctgggcaac agagcaagac tccatctcaa aaaaccaatc aaccaaccaa   3300

ccaacaaaaa acatttcaca tctccctgac gtagccaaca ttttctccaa cattctctta   3360

ttttgatggc agaagggcat aactgtaaat ctcagttttt atatggtatt gtataatata   3420

gtggcatcct ttgcggccag ttgattgtga agagcagttt gcctttactt agcttccatg   3480

aacattagct ttaaatgctc attgacatta atgagagcca gtttgctaaa tctgtgtctc   3540

cttcatgttc atttgctact tagttttgtt gattccaaga agtcactaat ttttttaaat   3600

catagattct gatttcgagg tagcttcatt tttctagtgt tgagtaaaat gtgtgtgtgt   3660

gtgtgcttta gtttaattaa tactaatttt tattcaaaat atatttgttg agcacttact   3720

ctctgctgtg gctgggcata cattactttc tttccacagt ccgttggttg aattgtcctg   3780

agcaggggtt gacaaatgat ggcctgtgag ccaaatctac cccactgcct gtttttgtaa   3840

ataaagcttt atcagaacat a                                             3861


<210>  7704
<211>  290
<212>  PRT
<213>  Homosapiens

<400>  7704

Met Tyr Glu Ser Phe Asp Gln Phe Ile Trp Ser Asp Val Arg Thr Ser 
1               5                   10                  15      


Cys Arg Leu Gln Cys Leu Arg Val Thr Ala Val Thr Ile Val Thr Asn 
            20                  25                  30          


Ser Asn Val Ala Gly Lys Leu Lys Ala Val Lys Asn Leu Pro Pro Thr 
        35                  40                  45              


Val Glu Phe Leu Val Pro Gly Ile Ala Thr Thr Thr His Gln His Lys 
    50                  55                  60                  


Ala Gln Ile Ala Ala Gln Leu Leu Gly Glu Gly Pro Val His Leu Ser 
65                  70                  75                  80  


Gly Ile Glu Lys Phe Trp Ser Gln Phe Glu Asp Phe Leu Leu His Lys 
                85                  90                  95      


Val Leu Ala Gly Ser Met Val Asp Thr Leu Met Ser Tyr Glu Lys Gln 
            100                 105                 110         


Glu Gly Thr Cys Pro Ser Thr Lys Arg Arg Arg Glu Pro Lys Thr Tyr 
        115                 120                 125             


Thr Phe Thr Lys Glu Glu Lys Ala Lys Cys Glu Val Thr Asp Thr His 
    130                 135                 140                 


Arg Ala Thr Pro Thr Thr Gly Gln Phe Lys Asn Val Lys Thr Lys Leu 
145                 150                 155                 160 


Gly Ser Arg Tyr His Pro Ser Thr Thr Ser Met Leu Val Pro Phe Ser 
                165                 170                 175     


Phe Leu Leu Cys Leu His Ala Ser Arg Arg Thr Val Thr Met Ser Pro 
            180                 185                 190         


Lys Asp Ser Thr Asp Tyr His Thr Leu Ser His Thr Glu Arg Trp Asn 
        195                 200                 205             


Tyr Phe Met Met Ile Ser Lys Lys Ile Phe Phe Ser Lys His Ser Tyr 
    210                 215                 220                 


Pro Lys Gly Ile Leu Lys Phe Leu Trp Asn Ala Leu Gly Gly Arg Glu 
225                 230                 235                 240 


Ser Ser Met Ser Thr Leu Leu Ala Glu Gly Lys Ala Asp Arg Gly Ser 
                245                 250                 255     


Gln Asn Glu Arg Lys Lys Gln Thr Gly Leu Arg Leu Pro Glu Met Gln 
            260                 265                 270         


Lys Leu Arg His Arg Ala Arg Met Cys His Ser Arg Ser Lys Leu Cys 
        275                 280                 285             


Trp Gln 
    290 


<210>  7705
<211>  504
<212>  DNA
<213>  Homosapiens

<400>  7705
gaattgaaaa gttttggagc cagttcgagg actttctcct gcacaaagtg ttggctggaa     60

gcatgaagca ataacacatg gtttgccaaa gaatctgcat tgaataatac tggtggtgac    120

cacaagaaca tgcctctctg actgcaagga acaagagtga cccagggttt cagctgctgc    180

cttggaaatt catcacagtg caagtctatg cttcccacgg gctgctccca gcctgtgaat    240

aagcctggca tctttgttga ggcaggccta tttctggaga tgcaggatcc tccgatgggc    300

gaatttggct ctaggactgc ttgatggcct tgacagactt tccttagaaa tgcatggcaa    360

tttagggttc ctccaccctt ccctctttct ctccttcacc tagggtcgga cttgcatcat    420

ggcctgaaag ctccaccagc ctctcctgcc ctcctcctca ttttctttca caggcatatc    480

ctctaataaa tttcttgcac attg                                           504


<210>  7706
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  7706

Met Leu Pro Thr Gly Cys Ser Gln Pro Val Asn Lys Pro Gly Ile Phe 
1               5                   10                  15      


Val Glu Ala Gly Leu Phe Leu Glu Met Gln Asp Pro Pro Met Gly Glu 
            20                  25                  30          


Phe Gly Ser Arg Thr Ala 
        35              


<210>  7707
<211>  571
<212>  DNA
<213>  Homosapiens

<400>  7707
caagggataa gcagggagca cttctggctg tgcataagag aggagtgttt ttatttgtgt     60

ttgtcaagga tgaacttatg agcaaactac aaaaggacat tgcctcttta acggaggctc    120

tggcttgtgt tcctgggagc ttcgcagcgt ttgttcgtaa agcagcatga aagagttgat    180

tttcatttta tgttgtgctt gtgaggcatt agcatgatgt tctaacactt gtaaatgaat    240

acagctctcg cctaatctgt cattttaatg ccttatagat tttatttcac tcgatgttgt    300

accagattct caataataat aatcaactgc tttgttgttc tcttgcagaa attaaatttc    360

tgcagtgagt gtgcaactaa taaaagatgt tgcttgagga aacaaaaaat aaatatgatg    420

aatcataaaa gttgggtggg gggagaaggg aagttgctcc tagatgaaag acaattactg    480

aaccagtgtg gttttcctcg gattctctaa caagtacaag accaaaaaga agccaaaaac    540

ctcttaattg tgtatactga aagaaaaaga a                                   571


<210>  7708
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  7708

Met Pro Tyr Arg Phe Tyr Phe Thr Arg Cys Cys Thr Arg Phe Ser Ile 
1               5                   10                  15      


Ile Ile Ile Asn Cys Phe Val Val Leu Leu Gln Lys Leu Asn Phe Cys 
            20                  25                  30          


Ser Glu Cys Ala Thr Asn Lys Arg Cys Cys Leu Arg Lys Gln Lys Ile 
        35                  40                  45              


Asn Met Met Asn His Lys Ser Trp Val Gly Gly Glu Gly Lys Leu Leu 
    50                  55                  60                  


Leu Asp Glu Arg Gln Leu Leu Asn Gln Cys Gly Phe Pro Arg Ile Leu 
65                  70                  75                  80  


<210>  7709
<211>  536
<212>  DNA
<213>  Homosapiens

<400>  7709
cataagggtt aatattatta ttgatttcct taagtctttc caacatccac gactgtgcat     60

taatcagtag ctaaaaagac cagaaaagac agaaaaattt aactactttg ttccctaatt    120

caaatttctt caagaagtcc ttctaaagat atggaactcc tgcatttttc ataaaacagt    180

ggttagatca atttccgtgt aagcaatgaa tcatctttat acttcacaaa agatggggag    240

caaagtttga cttaccaaag aaaggctgac tgattagtct ctgggtgaac agtctggtgg    300

gaagaccaca gattcctgac ccctgcacag gtttaacatg aagccctcca aggaaccttt    360

cagaactgca gcaatgactt acggtggctt cagagtgggg tggttggatg aatctgagga    420

tgtggaaccc gtggatatgg agggctgact caatgccttg atgagcttga agataagtat    480

atacccccga aaccaccacc acaaacaatg ccataaactt aaccactgcc tctaaa        536


<210>  7710
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  7710

Met Lys Pro Ser Lys Glu Pro Phe Arg Thr Ala Ala Met Thr Tyr Gly 
1               5                   10                  15      


Gly Phe Arg Val Gly Trp Leu Asp Glu Ser Glu Asp Val Glu Pro Val 
            20                  25                  30          


Asp Met Glu Gly 
        35      


<210>  7711
<211>  2001
<212>  DNA
<213>  Homosapiens

<400>  7711
tgtaatgatg ggagggagga tgcaaggcag gacttacggg tcctagccag ctgtgctgca     60

cctggtccgt gaggcagtgt ggagtccacc gaaacgaccc tcaagcctga tgccagttcc    120

agaagcccag tcggcaactc tgccacctta cactcctctc cccgtggaac tgcctggggg    180

tgctggcatg gggacatgag ggatgtctga caggagaaac aagcatttca agagtgtgtg    240

gttggcttcg ctgtcctttg gggggaggaa ctggaatcag tcaacaggcc cgactcccag    300

ttccagcctg aacactggtc agctgaagac aacgctgcca ccttcatctc ttccctgcct    360

gtcctgctta caacagttgc aagaagttta tacccacatt aagcccccag aggcaggctg    420

gcagccagcc ttcgccactg gtgcagagaa ctgagtcaac cacccggtgt tcctggctgc    480

tccccctgag aagctttccc accctgttcc ctgagtcgag agtcttggct gggcacctgc    540

tgcactgtgg acgtgcggac gcggcctcca gaagggggaa gggagccctg gctggcttct    600

ctgagacgtg ttgagtggct tgccattgaa gactgtttcc tcactcaggc agctgcatgc    660

cccaagtgag tgacttcctc tctctggact cagtttctga atctgtagac aaagagggtg    720

gaccagatgg tcttggaggt gccttccagg tcacatctct cctgtttcta acagcaggtg    780

gaagcaggtg aggagggcag tcgggcagag aggaatggag aggaattccc ccacagaggc    840

tcttgggaac cacacaattc cccattctgg tgccacctgc ttcaaggatg tgagtgagag    900

cagtgctggc cttgaagcct acatcggtgg gtagtctagc ctccctagat gtgtccttag    960

gtgtcatggg atccatatct ggatcatcaa ggagacctca cttaggcttc tcttgactta   1020

ccaggaaagg ctaagtcttg cttcgggcag gcagctgcct ctggggcccg ggcctgtggc   1080

cccaggggaa agaattgttg ccccaagatg ctcatgcaat gttgtgtgac tgtggcaagg   1140

ctgtgccatt ttagctggga tcaacacgct aatgggcaca ggtccagggg gagtgcaggt   1200

gccttcctgg gtgcaaagtg gccctcatcc ccatagcaca caatgtctgc acagctgagg   1260

ctggaaggga ctggctgagg gccgtgctgg tgtgggcaga tccctggaag atcacctggg   1320

ccatctcctc attctaaaga tgagaagaac gaggcttgga gaggatgagt gtcttgttga   1380

gggttgcaca gcaagttggg gacacagctg caggaaatcc aagtctcctg attcctagcc   1440

catgatattt tctctcccac caagttgaaa ggctgaggtg atgggaggcc tggcatacca   1500

cagatggaaa cttgcatcgt tgcccccggg gctcagatga ttctctaaaa atgtgtctga   1560

ggaagtgaga gtgcagggcc tctcctcaca cgttggagct gtaagtaggg cacgtgcttt   1620

cagctccagg caggactgga gaaggttatg gaagggcagc caaccaagaa gcacttattt   1680

aagcattttt atgtgcctag ccctgagcta ggcatagtag ggcataaagg agctttgaag   1740

gaccctccca acacagcaat ttcactgcag ctggtgagca aatttaactc acaaatcaat   1800

tacaaaaaca acctcatgca agctactgtt tgtgtaataa aatgtaagaa catatatttg   1860

tatttgcgta aaggaaatct ggaaggatat aaaaagataa taaaagtgtt aactaaacag   1920

ttacgtgatg gggtgggggt gagatttttg tcctttgtac cttttaatta caaaattatt   1980

ttgaactatg tgaatgcatt t                                             2001


<210>  7712
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  7712

Met Ser Asp Arg Arg Asn Lys His Phe Lys Ser Val Trp Leu Ala Ser 
1               5                   10                  15      


Leu Ser Phe Gly Gly Arg Asn Trp Asn Gln Ser Thr Gly Pro Thr Pro 
            20                  25                  30          


Ser Ser Ser Leu Asn Thr Gly Gln Leu Lys Thr Thr Leu Pro Pro Ser 
        35                  40                  45              


Ser Leu Pro Cys Leu Ser Cys Leu Gln Gln Leu Gln Glu Val Tyr Thr 
    50                  55                  60                  


His Ile Lys Pro Pro Glu Ala Gly Trp Gln Pro Ala Phe Ala Thr Gly 
65                  70                  75                  80  


Ala Glu Asn 
            


<210>  7713
<211>  698
<212>  DNA
<213>  Homosapiens

<400>  7713
gttattttta aggacattat tccaagagag aaaaaggtct taagtccact gcacctgaca     60

gagtattctt ttgttcctag aaggctggtt tctcttgaca tctctgccct cattaaaaaa    120

gcatatcaca gttgtcacct ttatgttttc agtcatgcag tttcaagccc caaaacagaa    180

tgttgtcatt tatttttctt ctgaagaaat ggcaccctgc tcacatgcat gcatgctcaa    240

cgccaaaaat ccgagaggac attcctgtag cacctctcta attcagagca cctggcaagt    300

ctgagttagc gagttgtctc aaccagggga tagtaaaggc tattttatgt cttccacgta    360

tattcactaa ctaggtaata atcacttgcc attagcacat gaaaattgtg cgtaagtggt    420

gctgctgaag agctagaaaa cagtttgttc tcaggtaggt aaatggtccc tcctgcagtc    480

ttgttcacac tgttaatttg ctgagcaaac cctttcctca aggactgtgc aaacaccggt    540

ttcgggctcc atgttaagga agctcacagg cagtcctctg cccccttgag acgacaattc    600

atcttccacc acaacaaagc cattttgcca caccattgtc tcccttcttc gtctttgtca    660

aagtacctca ccagtgaaag aaaagtgacc tctgcttc                            698


<210>  7714
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  7714

Met Phe Ser Val Met Gln Phe Gln Ala Pro Lys Gln Asn Val Val Ile 
1               5                   10                  15      


Tyr Phe Ser Ser Glu Glu Met Ala Pro Cys Ser His Ala Cys Met Leu 
            20                  25                  30          


Asn Ala Lys Asn Pro Arg Gly His Ser Cys Ser Thr Ser Leu Ile Gln 
        35                  40                  45              


Ser Thr Trp Gln Val 
    50              


<210>  7715
<211>  3942
<212>  DNA
<213>  Homosapiens

<400>  7715
gcttaaaaaa aagccatgac ggctctccca caattcatct tccctgcgcc atctttgtat     60

tatttctaat ttattttgga tgtcaaaagg cactgatgaa gatattttct ctggagtctc    120

cttctttcta acccggctct cccgatgtga accgagccgt cgtccgcccg ccgccgccgc    180

cgccgccgcc gccgcccgcc ccgcagccca ccatgtctcg ccgcaagcaa ggcaaacccc    240

agcacttaag caaacgggaa ttctcgcccg agcctcttga agccattctt acagatgatg    300

aaccagacca cggcccgttg ggagctccag aaggggatca tgacctcctc acctgtgggc    360

agtgccagat gaacttccca ttgggggaca ttcttatttt tatcgagcac aaacggaaac    420

aatgcaatgg cagcctctgc ttagaaaaag ctgtggataa gccaccttcc ccttcaccaa    480

tcgagatgaa aaaagcatcc aatcccgtgg aggttggcat ccaggtcacg ccagaggatg    540

acgattgttt atcaacgtca tctagaggaa tttgccccaa acaggaacac atagcagata    600

aacttctgca ctggaggggc ctctcctccc ctcgttctgc acatggagct ctaatcccca    660

cgcctgggat gagtgcagaa tatgccccgc agggtatttg taaagatgag cccagcagct    720

acacatgtac aacttgcaaa cagccattca ccagtgcatg gtttctcttg caacacgcac    780

agaacactca tggattaaga atctacttag aaagcgaaca cggaagtccc ctgaccccgc    840

gggttggtat cccttcagga ctaggtgcag aatgtccttc ccagccacct ctccatggga    900

ttcatattgc agacaataac ccctttaacc tgctaagaat accaggatca gtatcgagag    960

aggcttccgg cctggcagaa gggcgctttc cacccactcc ccccctgttt agtccaccac   1020

cgagacatca cttggacccc caccgcatag agcgcctggg ggcggaagag atggccctgg   1080

ccacccatca cccgagtgcc tttgacaggg tgctgcggtt gaatccaatg gctatggagc   1140

ctcccgccat ggatttctct aggagactta gagagctggc agggaacacg tctagcccac   1200

cgctgtcccc aggccggccc agccctatgc aaaggttact gcaaccattc cagccaggta   1260

gcaagccgcc cttcctggcg acgccccccc tccctcctct gcaatccgcc cctcctccct   1320

cccagccccc ggtcaagtcc aagtcatgcg agttctgcgg caagacgttc aaatttcaga   1380

gcaacctggt ggtgcaccgg cgcagccaca cgggcgagaa gccctacaag tgcaacctgt   1440

gcgaccacgc gtgcacccag gccagcaagc tgaagcgcca catgaagacg cacatgcaca   1500

aatcgtcccc catgacggtc aagtccgacg acggtctctc caccgccagc tccccggaac   1560

ccggcaccag cgacttggtg ggcagcgcca gcagcgcgct caagtccgtg gtggccaagt   1620

tcaagagcga gaacgacccc aacctgatcc cggagaacgg ggacgaggag gaagaggagg   1680

acgacgagga agaggaagaa gaggaggaag aggaggagga ggagctgacg gagagcgaga   1740

gggtggacta cggcttcggg ctgagcctgg aggcggcgcg ccaccacgag aacagctcgc   1800

ggggcgcggt cgtgggcgtg ggcgacgaga gccgcgccct gcccgacgtc atgcagggca   1860

tggtgctcag ctccatgcag cacttcagcg aggccttcca ccaggtcctg ggcgagaagc   1920

ataagcgcgg ccacctggcc gaggccgagg gccacaggga cacttgcgac gaagactcgg   1980

tggccggcga gtcggaccgc atagacgatg gcactgttaa tggccgcggc tgctccccgg   2040

gcgagtcggc ctcggggggc ctgtccaaaa agctgctgct gggcagcccc agctcgctga   2100

gccccttctc taagcgcatc aagctcgaga aggagttcga cctgcccccg gccgcgatgc   2160

ccaacacgga gaacgtgtac tcgcagtggc tcgccggcta cgcggcctcc aggcagctca   2220

aagatccctt ccttagcttc ggagactcca gacaatcgcc ttttgcctcc tcgtcggagc   2280

actcctcgga gaacgggagt ttgcgcttct ccacaccgcc cggggagctg gacggaggga   2340

tctcggggcg cagcggcacg ggaagtggag ggagcacgcc ccatattagt ggtccgggcc   2400

cgggcaggcc cagctcaaaa gagggcagac gcagcgacac ttgttcttca cacaccccca   2460

ttcggcgtag tacccagaga gctcaagatg tgtggcagtt ttcggatgga agctcgagag   2520

cccttaagtt ctgagaaaat ttgaagcccc caggggtggg gtggacgcgt gccgcccagt   2580

cgacgtcagc gtggtctgtc atcctgctag tttgtgatgt tttctgacag tagcctccaa   2640

gaagccgttg tgcgaagaca gagtcctgca gagtccttcc agcctaggcc tgcagcgcca   2700

ttttatttat attttttaat aaaaagtaaa aacaaaaaaa cagacccaca ttggaacagt   2760

gaatcagtcc catagagagg gcccgtggac catcgctgtc atgagtgatg ccctggccct   2820

tctgaaacca gccaacctaa ttacctgtat tgtggaaatg cgcatgagtc cccaacccct   2880

tgtttctata cattctatgt tgtcttttaa aaagtgtgct taacattgac acaataaatg   2940

ttggagcttt aggtggtgtt tgcttgttct ttaattttta atgcttataa gacaatgagg   3000

ctgcttatga ttttgtactt ctgtacctgt ttcctacaga cacccatcgg gtgggtagga   3060

ggaacagatt tgagaaatgg gcaggagatg taggagggga actaggttac cgcttatcag   3120

atggcataaa ttttcaagga gaatcaaaat gcaaaacttg ggaataaatc atagcaatat   3180

cataattaat gtagtagtaa tattgctgtt tattaatgct gaagtgtggt tttcctaact   3240

gtctgactta taatttgcat accattaaat aatgcataat atggcacgcc gaatcctgtt   3300

tttcaaatat atgcttttgg tggctaccat gcaggatttg aatttgtctt ttaatttagc   3360

ttaggaaaga acatcactgg gcgagcggta aatcctaaag aaggtgataa atgtcagtag   3420

tttcttatta aatattctaa ttttaggttc ccaaaccttc aggaaatata tcttaatgca   3480

gacaaacaaa cataaaactt ctttagtact tacatcagga aatttggggc agattttaga   3540

ggggggaaat tataggagga aagaagttca catcagaaca gacaatcaca gcaatgctct   3600

attccttaga aattagtgcc acaaataagt tacatctaca aacaggtggt aaaaattctt   3660

tctggcccag ttaatttgca cagaactttt ctcagtttgg tattttttac tgcttggaga   3720

tccagaagag aattagaaac aacatagcaa attaaaatag gtttgtcaat aatagagctc   3780

agacacctgt gtgctgtaga ttcacataca ggccgtgaac ctaagtgggg aaaatcctac   3840

ctatccacct tctggctaga ttacctagct tagtgaaaag atagccaaat aattggcatg   3900

tgaattattt cctgcttatt cataataaat aatgactgtc ta                      3942


<210>  7716
<211>  773
<212>  PRT
<213>  Homosapiens

<400>  7716

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys 
                165                 170                 175     


Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr 
        195                 200                 205             


Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln 
    210                 215                 220                 


Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu 
225                 230                 235                 240 


Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu 
                245                 250                 255     


Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His 
            260                 265                 270         


His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala 
        275                 280                 285             


Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn 
    290                 295                 300                 


Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg 
305                 310                 315                 320 


Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro 
                325                 330                 335     


Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro 
            340                 345                 350         


Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro 
        355                 360                 365             


Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys 
    370                 375                 380                 


Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln 
                405                 410                 415     


Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser 
            420                 425                 430         


Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro 
        435                 440                 445             


Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys 
    450                 455                 460                 


Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro 
465                 470                 475                 480 


Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp 
            500                 505                 510         


Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser 
        515                 520                 525             


Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro 
    530                 535                 540                 


Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu 
545                 550                 555                 560 


Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala 
                565                 570                 575     


Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly 
            580                 585                 590         


Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser 
        595                 600                 605             


Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly 
    610                 615                 620                 


Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys 
625                 630                 635                 640 


Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr 
                645                 650                 655     


Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro 
            660                 665                 670         


Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser 
        675                 680                 685             


Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly 
    690                 695                 700                 


Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly 
705                 710                 715                 720 


Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys 
                725                 730                 735     


Glu Gly Arg Arg Ser Asp Thr Cys Ser Ser His Thr Pro Ile Arg Arg 
            740                 745                 750         


Ser Thr Gln Arg Ala Gln Asp Val Trp Gln Phe Ser Asp Gly Ser Ser 
        755                 760                 765             


Arg Ala Leu Lys Phe 
    770             


<210>  7717
<211>  2342
<212>  DNA
<213>  Homosapiens

<400>  7717
gcttaaaaaa aagccatgac ggctctccca caattcatct tccctgcgcc atctttgtat     60

tatttctaat ttattttgga tgtcaaaagg cactgatgaa gatattttct ctggagtctc    120

cttctttcta acccggctct cccgatgtga accgagccgt cgtccgcccg ccgccgccgc    180

cgccgccgcc gccgcccgcc ccgcagccca ccatgtctcg ccgcaagcaa ggcaaacccc    240

agcacttaag caaacgggaa ttctcgcccg agcctcttga agccattctt acagatgatg    300

aaccagacca cggcccgttg ggagctccag aaggggatca tgacctcctc acctgtgggc    360

agtgccagat gaacttccca ttgggggaca ttcttatttt tatcgagcac aaacggaaac    420

aatgcaatgg cagcctctgc ttagaaaaag ctgtggataa gccaccttcc ccttcaccaa    480

tcgagatgaa aaaagcatcc aatcccgtgg aggttggcat ccaggtcacg ccagaggatg    540

acgattgttt atcaacgtca tctagaggaa tttgccccaa acaggaacac atagcagata    600

aacttctgca ctggaggggc ctctcctccc ctcgttctgc acatggagct ctaatcccca    660

cgcctgggat gagtgcagaa tatgccccgc agggtatttg taaagatgag cccagcagct    720

acacatgtac aacttgcaaa cagccattca ccagtgcatg gtttctcttg caacacgcac    780

agaacactca tggattaaga atctacttag aaagcgaaca cggaagtccc ctgaccccgc    840

gggttcttca cacaccccca ttcggcgtag tacccagaga gctcaagatg tgtggcagtt    900

ttcggatgga agctcgagag cccttaagtt ctgagaaaat ttgaagcccc caggggtggg    960

gtggacgcgt gccgcccagt cgacgtcagc gtggtctgtc atcctgctag tttgtgatgt   1020

tttctgacag tagcctccaa gaagccgttg tgcgaagaca gagtcctgca gagtccttcc   1080

agcctaggcc tgcagcgcca ttttatttat attttttaat aaaaagtaaa aacaaaaaaa   1140

cagacccaca ttggaacagt gaatcagtcc catagagagg gcccgtggac catcgctgtc   1200

atgagtgatg ccctggccct tctgaaacca gccaacctaa ttacctgtat tgtggaaatg   1260

cgcatgagtc cccaacccct tgtttctata cattctatgt tgtcttttaa aaagtgtgct   1320

taacattgac acaataaatg ttggagcttt aggtggtgtt tgcttgttct ttaattttta   1380

atgcttataa gacaatgagg ctgcttatga ttttgtactt ctgtacctgt ttcctacaga   1440

cacccatcgg gtgggtagga ggaacagatt tgagaaatgg gcaggagatg taggagggga   1500

actaggttac cgcttatcag atggcataaa ttttcaagga gaatcaaaat gcaaaacttg   1560

ggaataaatc atagcaatat cataattaat gtagtagtaa tattgctgtt tattaatgct   1620

gaagtgtggt tttcctaact gtctgactta taatttgcat accattaaat aatgcataat   1680

atggcacgcc gaatcctgtt tttcaaatat atgcttttgg tggctaccat gcaggatttg   1740

aatttgtctt ttaatttagc ttaggaaaga acatcactgg gcgagcggta aatcctaaag   1800

aaggtgataa atgtcagtag tttcttatta aatattctaa ttttaggttc ccaaaccttc   1860

aggaaatata tcttaatgca gacaaacaaa cataaaactt ctttagtact tacatcagga   1920

aatttggggc agattttaga ggggggaaat tataggagga aagaagttca catcagaaca   1980

gacaatcaca gcaatgctct attccttaga aattagtgcc acaaataagt tacatctaca   2040

aacaggtggt aaaaattctt tctggcccag ttaatttgca cagaactttt ctcagtttgg   2100

tattttttac tgcttggaga tccagaagag aattagaaac aacatagcaa attaaaatag   2160

gtttgtcaat aatagagctc agacacctgt gtgctgtaga ttcacataca ggccgtgaac   2220

ctaagtgggg aaaatcctac ctatccacct tctggctaga ttacctagct tagtgaaaag   2280

atagccaaat aattggcatg tgaattattt cctgcttatt cataataaat aatgactgtc   2340

ta                                                                  2342


<210>  7718
<211>  243
<212>  PRT
<213>  Homosapiens

<400>  7718

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys 
                165                 170                 175     


Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr 
        195                 200                 205             


Pro Arg Val Leu His Thr Pro Pro Phe Gly Val Val Pro Arg Glu Leu 
    210                 215                 220                 


Lys Met Cys Gly Ser Phe Arg Met Glu Ala Arg Glu Pro Leu Ser Ser 
225                 230                 235                 240 


Glu Lys Ile 
            


<210>  7719
<211>  3103
<212>  DNA
<213>  Homosapiens

<400>  7719
tgacgttcaa gttcgcaggg acgtcacgtc cgcacttgaa cttgcagctc aggggggctt     60

ttgccatttt tttcatctct ctctctctct ctccctctat ctctcttctc tctctctccc    120

tctttttttt tttttttttt tttttttttt tgcttaaaaa aaagccatga cggctctccc    180

acaattcatc ttccctgcgc catctttgta ttatttctaa tttattttgg atgtcaaaag    240

gcactgatga agatattttc tctggagtct ccttctttct aacccggctc tcccgatgtg    300

aaccgagccg tcgtccgccc gccgccgccg ccgccgccgc cgccgcccgc cccgcagccc    360

accatgtctc gccgcaagca aggcaaaccc cagcacttaa gcaaacggga attctcgccc    420

gagcctcttg aagccattct tacagatgat gaaccagacc acggcccgtt gggagctcca    480

gaaggggatc atgacctcct cacctgtggg cagtgccaga tgaacttccc attgggggac    540

attcttattt ttatcgagca caaacggaaa caatgcaatg gcagcctctg cttagaaaaa    600

gctgtggata agccaccttc cccttcacca atcgagatga aaaaagcatc caatcccgtg    660

gaggttggca tccaggtcac gccagaggat gacgattgtt tatcaacgtc atctagagga    720

atttgcccca aacaggaaca catagcagat aaacttctgc actggagggg cctctcctcc    780

cctcgttctg cacatggagc tctaatcccc acgcctggga tgagtgcaga atatgccccg    840

cagggtattt gtaaagatga gcccagcagc tacacatgta caacttgcaa acagccattc    900

accagtgcat ggtttctctt gcaacacgca cagaacactc atggattaag aatctactta    960

gaaagcgaac acggaagtcc cctgaccccg cgggttggta tcccttcagg actaggtgca   1020

gaatgtcctt cccagccacc tctccatggg attcatattg cagacaataa cccctttaac   1080

ctgctaagaa taccaggatc agtatcgaga gaggcttccg gcctggcaga agggcgcttt   1140

ccacccactc cccccctgtt tagtccacca ccgagacatc acttggaccc ccaccgcata   1200

gagcgcctgg gggcggaaga gatggccctg gccacccatc acccgagtgc ctttgacagg   1260

gtgctgcggt tgaatccaat ggctatggag cctcccgcca tggatttctc taggagactt   1320

agagagctgg cagggaacac gtctagccca ccgctgtccc caggccggcc cagccctatg   1380

caaaggttac tgcaaccatt ccagccaggt agcaagccgc ccttcctggc gacgcccccc   1440

ctccctcctc tgcaatccgc ccctcctccc tcccagcccc cggtcaagtc caagtcatgc   1500

gagttctgcg gcaagacgtt caaatttcag agcaacctgg tggtgcaccg gcgcagccac   1560

acgggcgaga agccctacaa gtgcaacctg tgcgaccacg cgtgcaccca ggccagcaag   1620

ctgaagcgcc acatgaagac gcacatgcac aaatcgtccc ccatgacggt caagtccgac   1680

gacggtctct ccaccgccag ctccccggaa cccggcacca gcgacttggt gggcagcgcc   1740

agcagcgcgc tcaagtccgt ggtggccaag ttcaagagcg agaacgaccc caacctgatc   1800

ccggagaacg gggacgagga ggaagaggag gacgacgagg aagaggaaga agaggaggaa   1860

gaggaggagg aggagctgac ggagagcgag agggtggact acggcttcgg gctgagcctg   1920

gaggcggcgc gccaccacga gaacagctcg cggggcgcgg tcgtgggcgt gggcgacgag   1980

agccgcgccc tgcccgacgt catgcagggc atggtgctca gctccatgca gcacttcagc   2040

gaggccttcc accaggtcct gggcgagaag cataagcgcg gccacctggc cgaggccgag   2100

ggccacaggg acacttgcga cgaagactcg gtggccggcg agtcggaccg catagacgat   2160

ggcactgtta atggccgcgg ctgctccccg ggcgagtcgg cctcgggggg cctgtccaaa   2220

aagctgctgc tgggcagccc cagctcgctg agccccttct ctaagcgcat caagctcgag   2280

aaggagttcg acctgccccc ggccgcgatg cccaacacgg agaacgtgta ctcgcagtgg   2340

ctcgccggct acgcggcctc caggcagctc aaagatccct tccttagctt cggagactcc   2400

agacaatcgc cttttgcctc ctcgtcggag cactcctcgg agaacgggag tttgcgcttc   2460

tccacaccgc ccggggagct ggacggaggg atctcggggc gcagcggcac gggaagtgga   2520

gggagcacgc cccatattag tggtccgggc ccgggcaggc ccagctcaaa agagggcaga   2580

cgcagcgaca cttgttcttc acacaccccc attcggcgta gtacccagag agctcaagat   2640

gtgtggcagt tttcggatgg aagctcgaga gcccttaagt tctgagaaaa tttgaagccc   2700

ccaggggtgg ggtggacgcg tgccgcccag tcgacgtcag cgtggtctgt catcctgcta   2760

gtttgtgatg ttttctgaca gtagcctcca agaagccgtt gtgcgaagac agagtcctgc   2820

agagtccttc cagcctaggc ctgcagcgcc attttattta tattttttaa taaaaagtaa   2880

aaacaaaaaa acagacccac attggaacag tgaatcagtc ccatagagag ggcccgtgga   2940

ccatcgctgt catgagtgat gccctggccc ttctgaaacc agccaaccta attacctgta   3000

ttgtggaaat gcgcatgagt ccccaacccc ttgtttctat acattctatg ttgtctttta   3060

aaaagtgtgc ttaacattga cacaataaat gttggagctt tag                     3103


<210>  7720
<211>  773
<212>  PRT
<213>  Homosapiens

<400>  7720

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys 
                165                 170                 175     


Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr 
        195                 200                 205             


Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln 
    210                 215                 220                 


Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu 
225                 230                 235                 240 


Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu 
                245                 250                 255     


Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His 
            260                 265                 270         


His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala 
        275                 280                 285             


Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn 
    290                 295                 300                 


Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg 
305                 310                 315                 320 


Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro 
                325                 330                 335     


Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro 
            340                 345                 350         


Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro 
        355                 360                 365             


Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys 
    370                 375                 380                 


Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln 
                405                 410                 415     


Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser 
            420                 425                 430         


Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro 
        435                 440                 445             


Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys 
    450                 455                 460                 


Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro 
465                 470                 475                 480 


Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp 
            500                 505                 510         


Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser 
        515                 520                 525             


Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro 
    530                 535                 540                 


Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu 
545                 550                 555                 560 


Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala 
                565                 570                 575     


Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly 
            580                 585                 590         


Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser 
        595                 600                 605             


Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly 
    610                 615                 620                 


Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys 
625                 630                 635                 640 


Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr 
                645                 650                 655     


Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro 
            660                 665                 670         


Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser 
        675                 680                 685             


Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly 
    690                 695                 700                 


Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly 
705                 710                 715                 720 


Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys 
                725                 730                 735     


Glu Gly Arg Arg Ser Asp Thr Cys Ser Ser His Thr Pro Ile Arg Arg 
            740                 745                 750         


Ser Thr Gln Arg Ala Gln Asp Val Trp Gln Phe Ser Asp Gly Ser Ser 
        755                 760                 765             


Arg Ala Leu Lys Phe 
    770             


<210>  7721
<211>  977
<212>  DNA
<213>  Homosapiens

<400>  7721
caatcttctg ggaaagagaa gaatgttccc ctccagttct gggcatattg aaggagcacg     60

gagctgttgg gaaaagttgc aatgctaaca tagacctcca ctgagagaat ttcagaatca    120

tttggtagtt gagaagcgcc tacttcatgc ggaggccccg tgggaggagt ggaagagttg    180

gcctcagcac tggcgagtat cggatgggag ctctgctcac ttgataaact tctgcactgg    240

aggggcctct cctcccctcg ttctgcacat ggagctctaa tccccacgcc tgggatgagt    300

gcagaatatg ccccgcaggg tatttgtaaa gatgagccca gcagctacac atgtacaact    360

tgcaaacagc cattcaccag tgcatggttt ctcttgcaac acgcacagaa cactcatgga    420

ttaagaatct acttagaaag cgaacacgga agtcccctga ccccgcgggt tcttcacaca    480

cccccattcg gcgtagtacc cagagagctc aagatgtgtg gcagttttcg gatggaagct    540

cgagagccct taagttctga gaaaatttga agcccccagg ggtggggtgg acgcgtgccg    600

cccagtcgac gtcagcgtgg tctgtcatcc tgctagtttg tgatgttttc tgacagtagc    660

ctccaagaag ccgttgtgcg aagacagagt cctgcagagt ccttccagcc taggcctgca    720

gcgccatttt atttatattt tttaataaaa agtaaaaaca aaaaaacaga cccacattgg    780

aacagtgaat cagtcccata gagagggccc gtggaccatc gctgtcatga gtgatgccct    840

ggcccttctg aaaccagcca acctaattac ctgtattgtg gaaatgcgca tgagtcccca    900

accccttgtt tctatacatt ctatgttgtc ttttaaaaag tgtgcttaac attgacacaa    960

taaatgttgg agcttta                                                   977


<210>  7722
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  7722

Met Ser Ala Glu Tyr Ala Pro Gln Gly Ile Cys Lys Asp Glu Pro Ser 
1               5                   10                  15      


Ser Tyr Thr Cys Thr Thr Cys Lys Gln Pro Phe Thr Ser Ala Trp Phe 
            20                  25                  30          


Leu Leu Gln His Ala Gln Asn Thr His Gly Leu Arg Ile Tyr Leu Glu 
        35                  40                  45              


Ser Glu His Gly Ser Pro Leu Thr Pro Arg Val Leu His Thr Pro Pro 
    50                  55                  60                  


Phe Gly Val Val Pro Arg Glu Leu Lys Met Cys Gly Ser Phe Arg Met 
65                  70                  75                  80  


Glu Ala Arg Glu Pro Leu Ser Ser Glu Lys Ile 
                85                  90      


<210>  7723
<211>  1021
<212>  DNA
<213>  Homosapiens

<400>  7723
gacgcggcgc gcggcggtgt gaagttacag cccggccagc cgagcctctt gaagccattc     60

ttacagatga tgaaccagac cacggcccgt tgggagctcc agaaggggat catgacctcc    120

tcacctgtgg gcagtgccag atgaacttcc cattggggga cattcttatt tttatcgagc    180

acaaacggaa acaatgcaat ggcagcctct gcttagaaaa agctgtggat aagccacctt    240

ccccttcacc aatcgagatg aaaaaagcat ccaatcccgt ggaggttggc atccaggtca    300

cgccagagga tgacgattgt ttatcaacgt catctagagg aatttgcccc aaacaggaac    360

acatagcagg taaagatgag cccagcagct acacatgtac aacttgcaaa cagccattca    420

ccagtgcatg gtttctcttg caacacgcac agaacactca tggattaaga atctacttag    480

aaagcgaaca cggaagtccc ctgaccccgc gggttcttca cacaccccca ttcggcgtag    540

tacccagaga gctcaagatg tgtggcagtt ttcggatgga agctcgagag cccttaagtt    600

ctgagaaaat ttgaagcccc caggggtggg gtggacgcgt gccgcccagt cgacgtcagc    660

gtggtctgtc atcctgctag tttgtgatgt tttctgacag tagcctccaa gaagccgttg    720

tgcgaagaca gagtcctgca gagtccttcc agcctaggcc tgcagcgcca ttttatttat    780

attttttaat aaaaagtaaa aacaaaaaaa cagacccaca ttggaacagt gaatcagtcc    840

catagagagg gcccgtggac catcgctgtc atgagtgatg ccctggccct tctgaaacca    900

gccaacctaa ttacctgtat tgtggaaatg cgcatgagtc cccaacccct tgtttctata    960

cattctatgt tgtcttttaa aaagtgtgct taacattgac acaataaatg ttggagcttt   1020

a                                                                   1021


<210>  7724
<211>  157
<212>  PRT
<213>  Homosapiens

<400>  7724

Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile Glu His Lys Arg 
1               5                   10                  15      


Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala Val Asp Lys Pro 
            20                  25                  30          


Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser Asn Pro Val Glu 
        35                  40                  45              


Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys Leu Ser Thr Ser 
    50                  55                  60                  


Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala Gly Lys Asp Glu 
65                  70                  75                  80  


Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys Gln Pro Phe Thr Ser Ala 
                85                  90                  95      


Trp Phe Leu Leu Gln His Ala Gln Asn Thr His Gly Leu Arg Ile Tyr 
            100                 105                 110         


Leu Glu Ser Glu His Gly Ser Pro Leu Thr Pro Arg Val Leu His Thr 
        115                 120                 125             


Pro Pro Phe Gly Val Val Pro Arg Glu Leu Lys Met Cys Gly Ser Phe 
    130                 135                 140                 


Arg Met Glu Ala Arg Glu Pro Leu Ser Ser Glu Lys Ile 
145                 150                 155         


<210>  7725
<211>  1351
<212>  DNA
<213>  Homosapiens

<400>  7725
gcttaaaaaa aagccatgac ggctctccca caattcatct tccctgcgcc atctttgtat     60

tatttctaat ttattttgga tgtcaaaagg cactgatgaa gatattttct ctggagtctc    120

cttctttcta acccggctct cccgatgtga accgagccgt cgtccgcccg ccgccgccgc    180

cgccgccgcc gccgcccgcc ccgcagccca ccatgtctcg ccgcaagcaa ggcaaacccc    240

agcacttaag caaacgggaa ttctcgcccg agcctcttga agccattctt acagatgatg    300

aaccagacca cggcccgttg ggagctccag aaggggatca tgacctcctc acctgtgggc    360

agtgccagat gaacttccca ttgggggaca ttcttatttt tatcgagcac aaacggaaac    420

aatgcaatgg cagcctctgc ttagaaaaag ctgtggataa gccaccttcc ccttcaccaa    480

tcgagatgaa aaaagcatcc aatcccgtgg aggttggcat ccaggtcacg ccagaggatg    540

acgattgttt atcaacgtca tctagaggaa tttgccccaa acaggaacac atagcagata    600

aacttctgca ctggaggggc ctctcctccc ctcgttctgc acatggagct ctaatcccca    660

cgcctgggat gagtgcagaa tatgccccgc agggtatttg taaagatgag cccagcagct    720

acacatgtac aacttgcaaa cagccattca ccagtgcatg gtttctcttg caacacgcac    780

agaacactca tggattaaga atctacttag aaagcgaaca cggaagtccc ctgaccccgc    840

gggttcttca cacaccccca ttcggcgtag tacccagaga gctcaagatg tgtggcagtt    900

ttcggatgga agctcgagag cccttaagtt ctgagaaaat ttgaagcccc caggggtggg    960

gtggacgcgt gccgcccagt cgacgtcagc gtggtctgtc atcctgctag tttgtgatgt   1020

tttctgacag tagcctccaa gaagccgttg tgcgaagaca gagtcctgca gagtccttcc   1080

agcctaggcc tgcagcgcca ttttatttat attttttaat aaaaagtaaa aacaaaaaaa   1140

cagacccaca ttggaacagt gaatcagtcc catagagagg gcccgtggac catcgctgtc   1200

atgagtgatg ccctggccct tctgaaacca gccaacctaa ttacctgtat tgtggaaatg   1260

cgcatgagtc cccaacccct tgtttctata cattctatgt tgtcttttaa aaagtgtgct   1320

taacattgac acaataaatg ttggagcttt a                                  1351


<210>  7726
<211>  243
<212>  PRT
<213>  Homosapiens

<400>  7726

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys 
                165                 170                 175     


Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr 
        195                 200                 205             


Pro Arg Val Leu His Thr Pro Pro Phe Gly Val Val Pro Arg Glu Leu 
    210                 215                 220                 


Lys Met Cys Gly Ser Phe Arg Met Glu Ala Arg Glu Pro Leu Ser Ser 
225                 230                 235                 240 


Glu Lys Ile 
            


<210>  7727
<211>  5386
<212>  DNA
<213>  Homosapiens

<400>  7727
agttcaaatg aaatccccac agcagagagc ttttgggtct agcagtggag cgataaactt     60

ctgcactgga ggggcctctc ctcccctcgt tctgcacatg gagctctaat ccccacgcct    120

gggatgagtg cagaatatgc cccgcagggt atttgtaaag atgagcccag cagctacaca    180

tgtacaactt gcaaacagcc attcaccagt gcatggtttc tcttgcaaca cgcacagaac    240

actcatggat taagaatcta cttagaaagc gaacacggaa gtcccctgac cccgcgggtt    300

ggtatccctt caggactagg tgcagaatgt ccttcccagc cacctctcca tgggattcat    360

attgcagaca ataacccctt taacctgcta agaataccag gatcagtatc gagagaggct    420

tccggcctgg cagaagggcg ctttccaccc actccccccc tgtttagtcc accaccgaga    480

catcacttgg acccccaccg catagagcgc ctgggggcgg aagagatggc cctggccacc    540

catcacccga gtgcctttga cagggtgctg cggttgaatc caatggctat ggagcctccc    600

gccatggatt tctctaggag acttagagag ctggcaggga acacgtctag cccaccgctg    660

tccccaggcc ggcccagccc tatgcaaagg ttactgcaac cattccagcc aggtagcaag    720

ccgcccttcc tggcgacgcc ccccctccct cctctgcaat ccgcccctcc tccctcccag    780

cccccggtca agtccaagtc atgcgagttc tgcggcaaga cgttcaaatt tcagagcaac    840

ctggtggtgc accggcgcag ccacacgggc gagaagccct acaagtgcaa cctgtgcgac    900

cacgcgtgca cccaggccag caagctgaag cgccacatga agacgcacat gcacaaatcg    960

tcccccatga cggtcaagtc cgacgacggt ctctccaccg ccagctcccc ggaacccggc   1020

accagcgact tggtgggcag cgccagcagc gcgctcaagt ccgtggtggc caagttcaag   1080

agcgagaacg accccaacct gatcccggag aacggggacg aggaggaaga ggaggacgac   1140

gaggaagagg aagaagagga ggaagaggag gaggaggagc tgacggagag cgagagggtg   1200

gactacggct tcgggctgag cctggaggcg gcgcgccacc acgagaacag ctcgcggggc   1260

gcggtcgtgg gcgtgggcga cgagagccgc gccctgcccg acgtcatgca gggcatggtg   1320

ctcagctcca tgcagcactt cagcgaggcc ttccaccagg tcctgggcga gaagcataag   1380

cgcggccacc tggccgaggc cgagggccac agggacactt gcgacgaaga ctcggtggcc   1440

ggcgagtcgg accgcataga cgatggcact gttaatggcc gcggctgctc cccgggcgag   1500

tcggcctcgg ggggcctgtc caaaaagctg ctgctgggca gccccagctc gctgagcccc   1560

ttctctaagc gcatcaagct cgagaaggag ttcgacctgc ccccggccgc gatgcccaac   1620

acggagaacg tgtactcgca gtggctcgcc ggctacgcgg cctccaggca gctcaaagat   1680

cccttcctta gcttcggaga ctccagacaa tcgccttttg cctcctcgtc ggagcactcc   1740

tcggagaacg ggagtttgcg cttctccaca ccgcccgggg agctggacgg agggatctcg   1800

gggcgcagcg gcacgggaag tggagggagc acgccccata ttagtggtcc gggcccgggc   1860

aggcccagct caaaagaggg cagacgcagc gacacttgtg agtactgtgg gaaagtcttc   1920

aagaactgta gcaatctcac tgtccacagg agaagccaca cgggcgaaag gccttataaa   1980

tgcgagctgt gcaactatgc ctgtgcccag agtagcaagc tcaccaggca catgaaaacg   2040

catggccagg tggggaagga cgtttacaaa tgtgaaattt gtaagatgcc ttttagcgtg   2100

tacagtaccc tggagaaaca catgaaaaaa tggcacagtg atcgagtgtt gaataatgat   2160

ataaaaactg aatagaggta tattaatacc cctccctcac tcccacctga cacccccttt   2220

ttcaccactc cccttcccca tcgccctcca gccccactcc ctgtaggatt tttttctagt   2280

cccatgtgat ttaaacaaac aaacaaacaa acagaagtaa cgaagctaag aatatgagag   2340

tgcttgtcac cagcacacct gttttttttc tttttctttt tcttttttct ttttcctttt   2400

tttttttttt cctttatgtt ctcaccgttt gaatgcatga tctgtatggg gcaatactat   2460

tgcattttac gcaaactttg agcctttctc ttgtgcaata atttacatgt tgtgtatgtt   2520

tttttttaaa cttagacagc atgtatggta tgttatggct attttaaatt gtccctaatt   2580

cgttgctgag caaacatgtt gctgtttcca gttccgttct gagagaaaaa gagagagaga   2640

gagaaaaaga ccatgctgca tacattctgt aatacatatc atgtacagtt ttattttata   2700

acgtgaggag gaaaaacagt ctttggatta accctctata gacagaatag atagcactga   2760

aaaaaaatct ctatgagcta aatgtctgtc tctaaagggt taaatgtatc aattggaaag   2820

gaagaaaaaa ggccttgaat tgacaaatta acagaaaaac agaacaagtt tattctatca   2880

tttggtttta aaatatgagt gccttggatc tattaaaacc acatcgatgg ttctttctac   2940

ttgttataaa cttgtagctt aattcagcat tgggtgaggt aataaacctt aggaactagc   3000

atataattct atattgtatt tctcacaaca atggctacct aaaaagatga cccattatgt   3060

cctagttaat catcattttt cctttagttt aattttataa acaaaactga ttataccagt   3120

ataaaagcta ctttgctcct ggtgagagct taaaagaaat gggctgtttt gcccaaagtt   3180

ttattttttt taaacaatga ttaaattgaa tgtgtaatgt gcaaaagccc tggaacgcaa   3240

ttaaatacac tagtaaggag ttcattttat gaagatattt gctttaataa tgtcttttta   3300

aaaatactgg caccaaaaga aatagatcca gatctacttg gttgtcaagt ggacaatcaa   3360

atgataaact ttaagacctt gtataccata ttgaaaggaa gaggctgaca ataaggtttg   3420

acagagggga acagaagaaa ataatatgat ttattagcac aacgtggtac tatttgccat   3480

ttaaaactag aacaggtata taagctaata ttgatacaat gatgattaac tatgaattct   3540

taagacttgc atttaaatgt gacattctta aaaaaagaag agaaagaatt ttaagagtag   3600

cagtatatat gtctgtgctc cctaaaagtt gtacttcatt tcttttccat acactgtgtg   3660

ctatttgtgt taacatggaa gaggattcat tgtttttatt tttatttttt taattttttc   3720

ttttttatta agctagcatc tgccccagtt ggtgttcaaa tagcacttga ctctgcctgt   3780

gatatctgta tcttttctct aatcagagat acagaggttg agtataaaat aaacctgctc   3840

agataggaca attaagtgca ctgtacaatt ttcccagttt acaggtctat acttaaggga   3900

aaagttgcaa gaatgctgaa aaaaaattga acacaatctc attgaggagc attttttaaa   3960

aactaaaaaa aaaaaaactt tgccagccat ttacttgact attgagctta cttacttgga   4020

cgcaacattg caagcgctgt gaatggaaac agaatacact taacatagaa atgaatgatt   4080

gctttcgctt ctacagtgca aggatttttt tgtacaaaac ttttttaaat ataaatgtta   4140

agaaaaattt tttttaaaaa acacttcatt atgtttaggg gggaactgca ttttagggtt   4200

ccattgtctt ggtggtgtta caagacttgt tatccattta aaaatggtag tggaaattct   4260

atgccttgga tacacaccgc tcttcaggtt gtaaaaaaaa aaaacataca ttggggaaag   4320

gtttaagatt atatagtact taaatatagg aaaatgcaca ctcatgttga ttcctatgct   4380

aaaatacatt tatggtcttt tttctgtatt tctagaatgg tatttgaatt aaatgttcat   4440

ctagtgttag gcactatagt atttatattg aagcttgtat ttttaactgt tgcttgttct   4500

cttaaaaggt atcaatgtac cttttttggt agtggaaaaa aaaaagacag gctgccacag   4560

tatatttttt taatttggca ggataatata gtgcaaatta tttgtatgct tcaaaaaaaa   4620

aaaaaagaga gaaacaaaaa agtgtgacat tacagatgag aagccatata atggcggttt   4680

gggggagcct gctagaatgt cacatggatg gctgtcatag gggttgtaca tatccttttt   4740

tgttcctttt tcctgctgcc atactgtatg cagtactgca agctaataac gttggtttgt   4800

tatgtagtgt gctttttgtc cctttccttc tatcacccta cattccagca tcttaccttc   4860

atatgcagta aaagaaagaa agaaaaaaaa aggaaaaaaa aaaaaaaacc aatgttttgc   4920

agtttttttc attgccaaaa actaaatggt gctttatatt tagattggaa agaatttcat   4980

atgcaaagca tattaaagag aaagcccgct ttagtcaata cttttttgta aatggcaatg   5040

cagaatattt tgttattggc cttttctatt cctgtaatga aagctgtttg tcgtaacttg   5100

aaattttatc ttttactatg ggagtcacta tttattattg cttatgtgcc ctgttcaaaa   5160

cagaggcact taatttgatc ttttattttt ctttgttttt attttttttt ttatttagat   5220

gaccaaaggt cattacaacc tggcttttta ttgtatttgt ttctggtctt tgttaagttc   5280

tattggaaaa accactgtct gtgttttttt ggcagttgtc tgcattaacc tgttcataca   5340

cccattttgt ccctttattg aaaaaataaa aaaaattaaa gtacac                  5386


<210>  7728
<211>  683
<212>  PRT
<213>  Homosapiens

<400>  7728

Met Ser Ala Glu Tyr Ala Pro Gln Gly Ile Cys Lys Asp Glu Pro Ser 
1               5                   10                  15      


Ser Tyr Thr Cys Thr Thr Cys Lys Gln Pro Phe Thr Ser Ala Trp Phe 
            20                  25                  30          


Leu Leu Gln His Ala Gln Asn Thr His Gly Leu Arg Ile Tyr Leu Glu 
        35                  40                  45              


Ser Glu His Gly Ser Pro Leu Thr Pro Arg Val Gly Ile Pro Ser Gly 
    50                  55                  60                  


Leu Gly Ala Glu Cys Pro Ser Gln Pro Pro Leu His Gly Ile His Ile 
65                  70                  75                  80  


Ala Asp Asn Asn Pro Phe Asn Leu Leu Arg Ile Pro Gly Ser Val Ser 
                85                  90                  95      


Arg Glu Ala Ser Gly Leu Ala Glu Gly Arg Phe Pro Pro Thr Pro Pro 
            100                 105                 110         


Leu Phe Ser Pro Pro Pro Arg His His Leu Asp Pro His Arg Ile Glu 
        115                 120                 125             


Arg Leu Gly Ala Glu Glu Met Ala Leu Ala Thr His His Pro Ser Ala 
    130                 135                 140                 


Phe Asp Arg Val Leu Arg Leu Asn Pro Met Ala Met Glu Pro Pro Ala 
145                 150                 155                 160 


Met Asp Phe Ser Arg Arg Leu Arg Glu Leu Ala Gly Asn Thr Ser Ser 
                165                 170                 175     


Pro Pro Leu Ser Pro Gly Arg Pro Ser Pro Met Gln Arg Leu Leu Gln 
            180                 185                 190         


Pro Phe Gln Pro Gly Ser Lys Pro Pro Phe Leu Ala Thr Pro Pro Leu 
        195                 200                 205             


Pro Pro Leu Gln Ser Ala Pro Pro Pro Ser Gln Pro Pro Val Lys Ser 
    210                 215                 220                 


Lys Ser Cys Glu Phe Cys Gly Lys Thr Phe Lys Phe Gln Ser Asn Leu 
225                 230                 235                 240 


Val Val His Arg Arg Ser His Thr Gly Glu Lys Pro Tyr Lys Cys Asn 
                245                 250                 255     


Leu Cys Asp His Ala Cys Thr Gln Ala Ser Lys Leu Lys Arg His Met 
            260                 265                 270         


Lys Thr His Met His Lys Ser Ser Pro Met Thr Val Lys Ser Asp Asp 
        275                 280                 285             


Gly Leu Ser Thr Ala Ser Ser Pro Glu Pro Gly Thr Ser Asp Leu Val 
    290                 295                 300                 


Gly Ser Ala Ser Ser Ala Leu Lys Ser Val Val Ala Lys Phe Lys Ser 
305                 310                 315                 320 


Glu Asn Asp Pro Asn Leu Ile Pro Glu Asn Gly Asp Glu Glu Glu Glu 
                325                 330                 335     


Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            340                 345                 350         


Leu Thr Glu Ser Glu Arg Val Asp Tyr Gly Phe Gly Leu Ser Leu Glu 
        355                 360                 365             


Ala Ala Arg His His Glu Asn Ser Ser Arg Gly Ala Val Val Gly Val 
    370                 375                 380                 


Gly Asp Glu Ser Arg Ala Leu Pro Asp Val Met Gln Gly Met Val Leu 
385                 390                 395                 400 


Ser Ser Met Gln His Phe Ser Glu Ala Phe His Gln Val Leu Gly Glu 
                405                 410                 415     


Lys His Lys Arg Gly His Leu Ala Glu Ala Glu Gly His Arg Asp Thr 
            420                 425                 430         


Cys Asp Glu Asp Ser Val Ala Gly Glu Ser Asp Arg Ile Asp Asp Gly 
        435                 440                 445             


Thr Val Asn Gly Arg Gly Cys Ser Pro Gly Glu Ser Ala Ser Gly Gly 
    450                 455                 460                 


Leu Ser Lys Lys Leu Leu Leu Gly Ser Pro Ser Ser Leu Ser Pro Phe 
465                 470                 475                 480 


Ser Lys Arg Ile Lys Leu Glu Lys Glu Phe Asp Leu Pro Pro Ala Ala 
                485                 490                 495     


Met Pro Asn Thr Glu Asn Val Tyr Ser Gln Trp Leu Ala Gly Tyr Ala 
            500                 505                 510         


Ala Ser Arg Gln Leu Lys Asp Pro Phe Leu Ser Phe Gly Asp Ser Arg 
        515                 520                 525             


Gln Ser Pro Phe Ala Ser Ser Ser Glu His Ser Ser Glu Asn Gly Ser 
    530                 535                 540                 


Leu Arg Phe Ser Thr Pro Pro Gly Glu Leu Asp Gly Gly Ile Ser Gly 
545                 550                 555                 560 


Arg Ser Gly Thr Gly Ser Gly Gly Ser Thr Pro His Ile Ser Gly Pro 
                565                 570                 575     


Gly Pro Gly Arg Pro Ser Ser Lys Glu Gly Arg Arg Ser Asp Thr Cys 
            580                 585                 590         


Glu Tyr Cys Gly Lys Val Phe Lys Asn Cys Ser Asn Leu Thr Val His 
        595                 600                 605             


Arg Arg Ser His Thr Gly Glu Arg Pro Tyr Lys Cys Glu Leu Cys Asn 
    610                 615                 620                 


Tyr Ala Cys Ala Gln Ser Ser Lys Leu Thr Arg His Met Lys Thr His 
625                 630                 635                 640 


Gly Gln Val Gly Lys Asp Val Tyr Lys Cys Glu Ile Cys Lys Met Pro 
                645                 650                 655     


Phe Ser Val Tyr Ser Thr Leu Glu Lys His Met Lys Lys Trp His Ser 
            660                 665                 670         


Asp Arg Val Leu Asn Asn Asp Ile Lys Thr Glu 
        675                 680             


<210>  7729
<211>  5829
<212>  DNA
<213>  Homosapiens

<400>  7729
gcttaaaaaa aagccatgac ggctctccca caattcatct tccctgcgcc atctttgtat     60

tatttctaat ttattttgga tgtcaaaagg cactgatgaa gatattttct ctggagtctc    120

cttctttcta acccggctct cccgatgtga accgagccgt cgtccgcccg ccgccgccgc    180

cgccgccgcc gccgcccgcc ccgcagccca ccatgtctcg ccgcaagcaa ggcaaacccc    240

agcacttaag caaacgggaa ttctcgcccg agcctcttga agccattctt acagatgatg    300

aaccagacca cggcccgttg ggagctccag aaggggatca tgacctcctc acctgtgggc    360

agtgccagat gaacttccca ttgggggaca ttcttatttt tatcgagcac aaacggaaac    420

aatgcaatgg cagcctctgc ttagaaaaag ctgtggataa gccaccttcc ccttcaccaa    480

tcgagatgaa aaaagcatcc aatcccgtgg aggttggcat ccaggtcacg ccagaggatg    540

acgattgttt atcaacgtca tctagaggaa tttgccccaa acaggaacac atagcaggta    600

aagatgagcc cagcagctac acatgtacaa cttgcaaaca gccattcacc agtgcatggt    660

ttctcttgca acacgcacag aacactcatg gattaagaat ctacttagaa agcgaacacg    720

gaagtcccct gaccccgcgg gttggtatcc cttcaggact aggtgcagaa tgtccttccc    780

agccacctct ccatgggatt catattgcag acaataaccc ctttaacctg ctaagaatac    840

caggatcagt atcgagagag gcttccggcc tggcagaagg gcgctttcca cccactcccc    900

ccctgtttag tccaccaccg agacatcact tggaccccca ccgcatagag cgcctggggg    960

cggaagagat ggccctggcc acccatcacc cgagtgcctt tgacagggtg ctgcggttga   1020

atccaatggc tatggagcct cccgccatgg atttctctag gagacttaga gagctggcag   1080

ggaacacgtc tagcccaccg ctgtccccag gccggcccag ccctatgcaa aggttactgc   1140

aaccattcca gccaggtagc aagccgccct tcctggcgac gccccccctc cctcctctgc   1200

aatccgcccc tcctccctcc cagcccccgg tcaagtccaa gtcatgcgag ttctgcggca   1260

agacgttcaa atttcagagc aacctggtgg tgcaccggcg cagccacacg ggcgagaagc   1320

cctacaagtg caacctgtgc gaccacgcgt gcacccaggc cagcaagctg aagcgccaca   1380

tgaagacgca catgcacaaa tcgtccccca tgacggtcaa gtccgacgac ggtctctcca   1440

ccgccagctc cccggaaccc ggcaccagcg acttggtggg cagcgccagc agcgcgctca   1500

agtccgtggt ggccaagttc aagagcgaga acgaccccaa cctgatcccg gagaacgggg   1560

acgaggagga agaggaggac gacgaggaag aggaagaaga ggaggaagag gaggaggagg   1620

agctgacgga gagcgagagg gtggactacg gcttcgggct gagcctggag gcggcgcgcc   1680

accacgagaa cagctcgcgg ggcgcggtcg tgggcgtggg cgacgagagc cgcgccctgc   1740

ccgacgtcat gcagggcatg gtgctcagct ccatgcagca cttcagcgag gccttccacc   1800

aggtcctggg cgagaagcat aagcgcggcc acctggccga ggccgagggc cacagggaca   1860

cttgcgacga agactcggtg gccggcgagt cggaccgcat agacgatggc actgttaatg   1920

gccgcggctg ctccccgggc gagtcggcct cggggggcct gtccaaaaag ctgctgctgg   1980

gcagccccag ctcgctgagc cccttctcta agcgcatcaa gctcgagaag gagttcgacc   2040

tgcccccggc cgcgatgccc aacacggaga acgtgtactc gcagtggctc gccggctacg   2100

cggcctccag gcagctcaaa gatcccttcc ttagcttcgg agactccaga caatcgcctt   2160

ttgcctcctc gtcggagcac tcctcggaga acgggagttt gcgcttctcc acaccgcccg   2220

gggagctgga cggagggatc tcggggcgca gcggcacggg aagtggaggg agcacgcccc   2280

atattagtgg tccgggcccg ggcaggccca gctcaaaaga gggcagacgc agcgacactt   2340

gtgagtactg tgggaaagtc ttcaagaact gtagcaatct cactgtccac aggagaagcc   2400

acacgggcga aaggccttat aaatgcgagc tgtgcaacta tgcctgtgcc cagagtagca   2460

agctcaccag gcacatgaaa acgcatggcc aggtggggaa ggacgtttac aaatgtgaaa   2520

tttgtaagat gccttttagc gtgtacagta ccctggagaa acacatgaaa aaatggcaca   2580

gtgatcgagt gttgaataat gatataaaaa ctgaatagag gtatattaat acccctccct   2640

cactcccacc tgacaccccc tttttcacca ctccccttcc ccatcgccct ccagccccac   2700

tccctgtagg atttttttct agtcccatgt gatttaaaca aacaaacaaa caaacagaag   2760

taacgaagct aagaatatga gagtgcttgt caccagcaca cctgtttttt ttctttttct   2820

ttttcttttt tctttttcct tttttttttt tttcctttat gttctcaccg tttgaatgca   2880

tgatctgtat ggggcaatac tattgcattt tacgcaaact ttgagccttt ctcttgtgca   2940

ataatttaca tgttgtgtat gttttttttt aaacttagac agcatgtatg gtatgttatg   3000

gctattttaa attgtcccta attcgttgct gagcaaacat gttgctgttt ccagttccgt   3060

tctgagagaa aaagagagag agagagaaaa agaccatgct gcatacattc tgtaatacat   3120

atcatgtaca gttttatttt ataacgtgag gaggaaaaac agtctttgga ttaaccctct   3180

atagacagaa tagatagcac tgaaaaaaaa tctctatgag ctaaatgtct gtctctaaag   3240

ggttaaatgt atcaattgga aaggaagaaa aaaggccttg aattgacaaa ttaacagaaa   3300

aacagaacaa gtttattcta tcatttggtt ttaaaatatg agtgccttgg atctattaaa   3360

accacatcga tggttctttc tacttgttat aaacttgtag cttaattcag cattgggtga   3420

ggtaataaac cttaggaact agcatataat tctatattgt atttctcaca acaatggcta   3480

cctaaaaaga tgacccatta tgtcctagtt aatcatcatt tttcctttag tttaatttta   3540

taaacaaaac tgattatacc agtataaaag ctactttgct cctggtgaga gcttaaaaga   3600

aatgggctgt tttgcccaaa gttttatttt ttttaaacaa tgattaaatt gaatgtgtaa   3660

tgtgcaaaag ccctggaacg caattaaata cactagtaag gagttcattt tatgaagata   3720

tttgctttaa taatgtcttt ttaaaaatac tggcaccaaa agaaatagat ccagatctac   3780

ttggttgtca agtggacaat caaatgataa actttaagac cttgtatacc atattgaaag   3840

gaagaggctg acaataaggt ttgacagagg ggaacagaag aaaataatat gatttattag   3900

cacaacgtgg tactatttgc catttaaaac tagaacaggt atataagcta atattgatac   3960

aatgatgatt aactatgaat tcttaagact tgcatttaaa tgtgacattc ttaaaaaaag   4020

aagagaaaga attttaagag tagcagtata tatgtctgtg ctccctaaaa gttgtacttc   4080

atttcttttc catacactgt gtgctatttg tgttaacatg gaagaggatt cattgttttt   4140

atttttattt ttttaatttt ttctttttta ttaagctagc atctgcccca gttggtgttc   4200

aaatagcact tgactctgcc tgtgatatct gtatcttttc tctaatcaga gatacagagg   4260

ttgagtataa aataaacctg ctcagatagg acaattaagt gcactgtaca attttcccag   4320

tttacaggtc tatacttaag ggaaaagttg caagaatgct gaaaaaaaat tgaacacaat   4380

ctcattgagg agcatttttt aaaaactaaa aaaaaaaaaa ctttgccagc catttacttg   4440

actattgagc ttacttactt ggacgcaaca ttgcaagcgc tgtgaatgga aacagaatac   4500

acttaacata gaaatgaatg attgctttcg cttctacagt gcaaggattt ttttgtacaa   4560

aactttttta aatataaatg ttaagaaaaa ttttttttaa aaaacacttc attatgttta   4620

ggggggaact gcattttagg gttccattgt cttggtggtg ttacaagact tgttatccat   4680

ttaaaaatgg tagtggaaat tctatgcctt ggatacacac cgctcttcag gttgtaaaaa   4740

aaaaaaacat acattgggga aaggtttaag attatatagt acttaaatat aggaaaatgc   4800

acactcatgt tgattcctat gctaaaatac atttatggtc ttttttctgt atttctagaa   4860

tggtatttga attaaatgtt catctagtgt taggcactat agtatttata ttgaagcttg   4920

tatttttaac tgttgcttgt tctcttaaaa ggtatcaatg tacctttttt ggtagtggaa   4980

aaaaaaaaga caggctgcca cagtatattt ttttaatttg gcaggataat atagtgcaaa   5040

ttatttgtat gcttcaaaaa aaaaaaaaag agagaaacaa aaaagtgtga cattacagat   5100

gagaagccat ataatggcgg tttgggggag cctgctagaa tgtcacatgg atggctgtca   5160

taggggttgt acatatcctt ttttgttcct ttttcctgct gccatactgt atgcagtact   5220

gcaagctaat aacgttggtt tgttatgtag tgtgcttttt gtccctttcc ttctatcacc   5280

ctacattcca gcatcttacc ttcatatgca gtaaaagaaa gaaagaaaaa aaaaggaaaa   5340

aaaaaaaaaa accaatgttt tgcagttttt ttcattgcca aaaactaaat ggtgctttat   5400

atttagattg gaaagaattt catatgcaaa gcatattaaa gagaaagccc gctttagtca   5460

atactttttt gtaaatggca atgcagaata ttttgttatt ggccttttct attcctgtaa   5520

tgaaagctgt ttgtcgtaac ttgaaatttt atcttttact atgggagtca ctatttatta   5580

ttgcttatgt gccctgttca aaacagaggc acttaatttg atcttttatt tttctttgtt   5640

tttatttttt tttttattta gatgaccaaa ggtcattaca acctggcttt ttattgtatt   5700

tgtttctggt ctttgttaag ttctattgga aaaaccactg tctgtgtttt tttggcagtt   5760

gtctgcatta acctgttcat acacccattt tgtcccttta ttgaaaaaat aaaaaaaatt   5820

aaagtacac                                                           5829


<210>  7730
<211>  801
<212>  PRT
<213>  Homosapiens

<400>  7730

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Gly Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys Gln Pro 
    130                 135                 140                 


Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr His Gly 
145                 150                 155                 160 


Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr Pro Arg 
                165                 170                 175     


Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln Pro Pro 
            180                 185                 190         


Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu Leu Arg 
        195                 200                 205             


Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu Gly Arg 
    210                 215                 220                 


Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His His Leu 
225                 230                 235                 240 


Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala Leu Ala 
                245                 250                 255     


Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn Pro Met 
            260                 265                 270         


Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg Glu Leu 
        275                 280                 285             


Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro Ser Pro 
    290                 295                 300                 


Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro Pro Phe 
305                 310                 315                 320 


Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro Pro Ser 
                325                 330                 335     


Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys Thr Phe 
            340                 345                 350         


Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr Gly Glu 
        355                 360                 365             


Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln Ala Ser 
    370                 375                 380                 


Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser Pro Met 
385                 390                 395                 400 


Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro Glu Pro 
                405                 410                 415     


Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys Ser Val 
            420                 425                 430         


Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro Glu Asn 
        435                 440                 445             


Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu 
    450                 455                 460                 


Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp Tyr Gly 
465                 470                 475                 480 


Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser Ser Arg 
                485                 490                 495     


Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro Asp Val 
            500                 505                 510         


Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu Ala Phe 
        515                 520                 525             


His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala Glu Ala 
    530                 535                 540                 


Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly Glu Ser 
545                 550                 555                 560 


Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser Pro Gly 
                565                 570                 575     


Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly Ser Pro 
            580                 585                 590         


Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys Glu Phe 
        595                 600                 605             


Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr Ser Gln 
    610                 615                 620                 


Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro Phe Leu 
625                 630                 635                 640 


Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser Glu His 
                645                 650                 655     


Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly Glu Leu 
            660                 665                 670         


Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly Ser Thr 
        675                 680                 685             


Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys Glu Gly 
    690                 695                 700                 


Arg Arg Ser Asp Thr Cys Glu Tyr Cys Gly Lys Val Phe Lys Asn Cys 
705                 710                 715                 720 


Ser Asn Leu Thr Val His Arg Arg Ser His Thr Gly Glu Arg Pro Tyr 
                725                 730                 735     


Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys Leu Thr 
            740                 745                 750         


Arg His Met Lys Thr His Gly Gln Val Gly Lys Asp Val Tyr Lys Cys 
        755                 760                 765             


Glu Ile Cys Lys Met Pro Phe Ser Val Tyr Ser Thr Leu Glu Lys His 
    770                 775                 780                 


Met Lys Lys Trp His Ser Asp Arg Val Leu Asn Asn Asp Ile Lys Thr 
785                 790                 795                 800 


Glu 
    


<210>  7731
<211>  5947
<212>  DNA
<213>  Homosapiens

<400>  7731
tttttttttt ttttttgctt aaaaaaaagc catgacggct ctcccacaat tcatcttccc     60

tgcgccatct ttgtattatt tctaatttat tttggatgtc aaaaggcact gatgaagata    120

ttttctctgg agtctccttc tttctaaccc ggctctcccg atgtgaaccg agccgtcgtc    180

cgcccgccgc cgccgccgcc gccgccgccg cccgccccgc agcccaccat gtctcgccgc    240

aagcaaggca aaccccagca cttaagcaaa cgggaattct cgcccgagcc tcttgaagcc    300

attcttacag atgatgaacc agaccacggc ccgttgggag ctccagaagg ggatcatgac    360

ctcctcacct gtgggcagtg ccagatgaac ttcccattgg gggacattct tatttttatc    420

gagcacaaac ggaaacaatg caatggcagc ctctgcttag aaaaagctgt ggataagcca    480

ccttcccctt caccaatcga gatgaaaaaa gcatccaatc ccgtggaggt tggcatccag    540

gtcacgccag aggatgacga ttgtttatca acgtcatcta gaggaatttg ccccaaacag    600

gaacacatag cagataaact tctgcactgg aggggcctct cctcccctcg ttctgcacat    660

ggagctctaa tccccacgcc tgggatgagt gcagaatatg ccccgcaggg tatttgtaaa    720

gatgagccca gcagctacac atgtacaact tgcaaacagc cattcaccag tgcatggttt    780

ctcttgcaac acgcacagaa cactcatgga ttaagaatct acttagaaag cgaacacgga    840

agtcccctga ccccgcgggt tggtatccct tcaggactag gtgcagaatg tccttcccag    900

ccacctctcc atgggattca tattgcagac aataacccct ttaacctgct aagaatacca    960

ggatcagtat cgagagaggc ttccggcctg gcagaagggc gctttccacc cactcccccc   1020

ctgtttagtc caccaccgag acatcacttg gacccccacc gcatagagcg cctgggggcg   1080

gaagagatgg ccctggccac ccatcacccg agtgcctttg acagggtgct gcggttgaat   1140

ccaatggcta tggagcctcc cgccatggat ttctctagga gacttagaga gctggcaggg   1200

aacacgtcta gcccaccgct gtccccaggc cggcccagcc ctatgcaaag gttactgcaa   1260

ccattccagc caggtagcaa gccgcccttc ctggcgacgc cccccctccc tcctctgcaa   1320

tccgcccctc ctccctccca gcccccggtc aagtccaagt catgcgagtt ctgcggcaag   1380

acgttcaaat ttcagagcaa cctggtggtg caccggcgca gccacacggg cgagaagccc   1440

tacaagtgca acctgtgcga ccacgcgtgc acccaggcca gcaagctgaa gcgccacatg   1500

aagacgcaca tgcacaaatc gtcccccatg acggtcaagt ccgacgacgg tctctccacc   1560

gccagctccc cggaacccgg caccagcgac ttggtgggca gcgccagcag cgcgctcaag   1620

tccgtggtgg ccaagttcaa gagcgagaac gaccccaacc tgatcccgga gaacggggac   1680

gaggaggaag aggaggacga cgaggaagag gaagaagagg aggaagagga ggaggaggag   1740

ctgacggaga gcgagagggt ggactacggc ttcgggctga gcctggaggc ggcgcgccac   1800

cacgagaaca gctcgcgggg cgcggtcgtg ggcgtgggcg acgagagccg cgccctgccc   1860

gacgtcatgc agggcatggt gctcagctcc atgcagcact tcagcgaggc cttccaccag   1920

gtcctgggcg agaagcataa gcgcggccac ctggccgagg ccgagggcca cagggacact   1980

tgcgacgaag actcggtggc cggcgagtcg gaccgcatag acgatggcac tgttaatggc   2040

cgcggctgct ccccgggcga gtcggcctcg gggggcctgt ccaaaaagct gctgctgggc   2100

agccccagct cgctgagccc cttctctaag cgcatcaagc tcgagaagga gttcgacctg   2160

cccccggccg cgatgcccaa cacggagaac gtgtactcgc agtggctcgc cggctacgcg   2220

gcctccaggc agctcaaaga tcccttcctt agcttcggag actccagaca atcgcctttt   2280

gcctcctcgt cggagcactc ctcggagaac gggagtttgc gcttctccac accgcccggg   2340

gagctggacg gagggatctc ggggcgcagc ggcacgggaa gtggagggag cacgccccat   2400

attagtggtc cgggcccggg caggcccagc tcaaaagagg gcagacgcag cgacacttgt   2460

gagtactgtg ggaaagtctt caagaactgt agcaatctca ctgtccacag gagaagccac   2520

acgggcgaaa ggccttataa atgcgagctg tgcaactatg cctgtgccca gagtagcaag   2580

ctcaccaggc acatgaaaac gcatggccag gtggggaagg acgtttacaa atgtgaaatt   2640

tgtaagatgc cttttagcgt gtacagtacc ctggagaaac acatgaaaaa atggcacagt   2700

gatcgagtgt tgaataatga tataaaaact gaatagaggt atattaatac ccctccctca   2760

ctcccacctg acaccccctt tttcaccact ccccttcccc atcgccctcc agccccactc   2820

cctgtaggat ttttttctag tcccatgtga tttaaacaaa caaacaaaca aacagaagta   2880

acgaagctaa gaatatgaga gtgcttgtca ccagcacacc tgtttttttt ctttttcttt   2940

ttcttttttc tttttccttt tttttttttt tcctttatgt tctcaccgtt tgaatgcatg   3000

atctgtatgg ggcaatacta ttgcatttta cgcaaacttt gagcctttct cttgtgcaat   3060

aatttacatg ttgtgtatgt ttttttttaa acttagacag catgtatggt atgttatggc   3120

tattttaaat tgtccctaat tcgttgctga gcaaacatgt tgctgtttcc agttccgttc   3180

tgagagaaaa agagagagag agagaaaaag accatgctgc atacattctg taatacatat   3240

catgtacagt tttattttat aacgtgagga ggaaaaacag tctttggatt aaccctctat   3300

agacagaata gatagcactg aaaaaaaatc tctatgagct aaatgtctgt ctctaaaggg   3360

ttaaatgtat caattggaaa ggaagaaaaa aggccttgaa ttgacaaatt aacagaaaaa   3420

cagaacaagt ttattctatc atttggtttt aaaatatgag tgccttggat ctattaaaac   3480

cacatcgatg gttctttcta cttgttataa acttgtagct taattcagca ttgggtgagg   3540

taataaacct taggaactag catataattc tatattgtat ttctcacaac aatggctacc   3600

taaaaagatg acccattatg tcctagttaa tcatcatttt tcctttagtt taattttata   3660

aacaaaactg attataccag tataaaagct actttgctcc tggtgagagc ttaaaagaaa   3720

tgggctgttt tgcccaaagt tttatttttt ttaaacaatg attaaattga atgtgtaatg   3780

tgcaaaagcc ctggaacgca attaaataca ctagtaagga gttcatttta tgaagatatt   3840

tgctttaata atgtcttttt aaaaatactg gcaccaaaag aaatagatcc agatctactt   3900

ggttgtcaag tggacaatca aatgataaac tttaagacct tgtataccat attgaaagga   3960

agaggctgac aataaggttt gacagagggg aacagaagaa aataatatga tttattagca   4020

caacgtggta ctatttgcca tttaaaacta gaacaggtat ataagctaat attgatacaa   4080

tgatgattaa ctatgaattc ttaagacttg catttaaatg tgacattctt aaaaaaagaa   4140

gagaaagaat tttaagagta gcagtatata tgtctgtgct ccctaaaagt tgtacttcat   4200

ttcttttcca tacactgtgt gctatttgtg ttaacatgga agaggattca ttgtttttat   4260

ttttattttt ttaatttttt cttttttatt aagctagcat ctgccccagt tggtgttcaa   4320

atagcacttg actctgcctg tgatatctgt atcttttctc taatcagaga tacagaggtt   4380

gagtataaaa taaacctgct cagataggac aattaagtgc actgtacaat tttcccagtt   4440

tacaggtcta tacttaaggg aaaagttgca agaatgctga aaaaaaattg aacacaatct   4500

cattgaggag cattttttaa aaactaaaaa aaaaaaaact ttgccagcca tttacttgac   4560

tattgagctt acttacttgg acgcaacatt gcaagcgctg tgaatggaaa cagaatacac   4620

ttaacataga aatgaatgat tgctttcgct tctacagtgc aaggattttt ttgtacaaaa   4680

cttttttaaa tataaatgtt aagaaaaatt ttttttaaaa aacacttcat tatgtttagg   4740

ggggaactgc attttagggt tccattgtct tggtggtgtt acaagacttg ttatccattt   4800

aaaaatggta gtggaaattc tatgccttgg atacacaccg ctcttcaggt tgtaaaaaaa   4860

aaaaacatac attggggaaa ggtttaagat tatatagtac ttaaatatag gaaaatgcac   4920

actcatgttg attcctatgc taaaatacat ttatggtctt ttttctgtat ttctagaatg   4980

gtatttgaat taaatgttca tctagtgtta ggcactatag tatttatatt gaagcttgta   5040

tttttaactg ttgcttgttc tcttaaaagg tatcaatgta ccttttttgg tagtggaaaa   5100

aaaaaagaca ggctgccaca gtatattttt ttaatttggc aggataatat agtgcaaatt   5160

atttgtatgc ttcaaaaaaa aaaaaaagag agaaacaaaa aagtgtgaca ttacagatga   5220

gaagccatat aatggcggtt tgggggagcc tgctagaatg tcacatggat ggctgtcata   5280

ggggttgtac atatcctttt ttgttccttt ttcctgctgc catactgtat gcagtactgc   5340

aagctaataa cgttggtttg ttatgtagtg tgctttttgt ccctttcctt ctatcaccct   5400

acattccagc atcttacctt catatgcagt aaaagaaaga aagaaaaaaa aaggaaaaaa   5460

aaaaaaaaac caatgttttg cagttttttt cattgccaaa aactaaatgg tgctttatat   5520

ttagattgga aagaatttca tatgcaaagc atattaaaga gaaagcccgc tttagtcaat   5580

acttttttgt aaatggcaat gcagaatatt ttgttattgg ccttttctat tcctgtaatg   5640

aaagctgttt gtcgtaactt gaaattttat cttttactat gggagtcact atttattatt   5700

gcttatgtgc cctgttcaaa acagaggcac ttaatttgat cttttatttt tctttgtttt   5760

tatttttttt tttatttaga tgaccaaagg tcattacaac ctggcttttt attgtatttg   5820

tttctggtct ttgttaagtt ctattggaaa aaccactgtc tgtgtttttt tggcagttgt   5880

ctgcattaac ctgttcatac acccattttg tccctttatt gaaaaaataa aaaaaattaa   5940

agtacac                                                             5947


<210>  7732
<211>  835
<212>  PRT
<213>  Homosapiens

<400>  7732

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys 
                165                 170                 175     


Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr 
        195                 200                 205             


Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln 
    210                 215                 220                 


Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu 
225                 230                 235                 240 


Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu 
                245                 250                 255     


Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His 
            260                 265                 270         


His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala 
        275                 280                 285             


Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn 
    290                 295                 300                 


Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg 
305                 310                 315                 320 


Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro 
                325                 330                 335     


Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro 
            340                 345                 350         


Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro 
        355                 360                 365             


Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys 
    370                 375                 380                 


Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln 
                405                 410                 415     


Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser 
            420                 425                 430         


Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro 
        435                 440                 445             


Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys 
    450                 455                 460                 


Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro 
465                 470                 475                 480 


Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp 
            500                 505                 510         


Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser 
        515                 520                 525             


Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro 
    530                 535                 540                 


Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu 
545                 550                 555                 560 


Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala 
                565                 570                 575     


Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly 
            580                 585                 590         


Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser 
        595                 600                 605             


Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly 
    610                 615                 620                 


Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys 
625                 630                 635                 640 


Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr 
                645                 650                 655     


Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro 
            660                 665                 670         


Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser 
        675                 680                 685             


Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly 
    690                 695                 700                 


Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly 
705                 710                 715                 720 


Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys 
                725                 730                 735     


Glu Gly Arg Arg Ser Asp Thr Cys Glu Tyr Cys Gly Lys Val Phe Lys 
            740                 745                 750         


Asn Cys Ser Asn Leu Thr Val His Arg Arg Ser His Thr Gly Glu Arg 
        755                 760                 765             


Pro Tyr Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys 
    770                 775                 780                 


Leu Thr Arg His Met Lys Thr His Gly Gln Val Gly Lys Asp Val Tyr 
785                 790                 795                 800 


Lys Cys Glu Ile Cys Lys Met Pro Phe Ser Val Tyr Ser Thr Leu Glu 
                805                 810                 815     


Lys His Met Lys Lys Trp His Ser Asp Arg Val Leu Asn Asn Asp Ile 
            820                 825                 830         


Lys Thr Glu 
        835 


<210>  7733
<211>  1162
<212>  DNA
<213>  Homosapiens

<400>  7733
gacagcagag gaccccagtt gttgaggact aaagagagag aagatgagaa agaagatgct     60

ggaaacagag gttggagaaa gagaggcaag gaagtagaaa ggaggaaaag gggaagagag    120

gaggcagggg gagagagggt tggaattcga gctattttca gctgaatgtg agtgcagatt    180

tcatcaggct tctgggctac agggaaactg actgtgtgcg gaccttgcgt gtaacttcct    240

gtgaagcagc cgtggtgact gcattttctg acactgtcag agtctggaca accctgccag    300

ctcctagaag ggcaacccaa caactgtcac agacgaagca tcaaaagcat gagctgtcga    360

tagtgacctg catttgcaga aaatctgagg gctttctaat taacagagga gctctaaatt    420

agagtaaagc tgttcgacaa gacccctcat acgcgataaa cttctgcact ggaggggcct    480

ctcctcccct cgttctgcac atggagctct aatccccacg cctgggatga gtgcagaata    540

tgccccgcag ggtatttgta aagatgagcc cagcagctac acatgtacaa cttgcaaaca    600

gccattcacc agtgcatggt ttctcttgca acacgcacag aacactcatg gattaagaat    660

ctacttagaa agcgaacacg gaagtcccct gaccccgcgg gttggtatcc cttcaggact    720

aggtgcagaa tgtccttccc agccacctct ccatgggatt catattgcag acaataaccc    780

ctttaacctg ctaagaatac caggatcagt atcgagagag gcttccggcc tggcagaagg    840

gcgctttcca cccactcccc ccctgtttag tccaccaccg agacatcact tggaccccca    900

ccgcatagag cgcctggggg cggaagagat ggccctggcc acccatcacc cgagtgcctt    960

tgacagggtg ctgcggttga atccaatggc tatggagcct cccgccatgg atttctctag   1020

gagacttaga gagctggcag ggaacacgtc tagcccaccg ctgtccccag gccggcccag   1080

ccctatgcaa aggttactgc aaccattcca gccaggtagc aagccgccct tcctggcgac   1140

gccccccctc cctcctctgc aa                                            1162


<210>  7734
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  7734

Met Ser Ala Glu Tyr Ala Pro Gln Gly Ile Cys Lys Asp Glu Pro Ser 
1               5                   10                  15      


Ser Tyr Thr Cys Thr Thr Cys Lys Gln Pro Phe Thr Ser Ala Trp Phe 
            20                  25                  30          


Leu Leu Gln His Ala Gln Asn Thr His Gly Leu Arg Ile Tyr Leu Glu 
        35                  40                  45              


Ser Glu His Gly Ser Pro Leu Thr Pro Arg Val Gly Ile Pro Ser Gly 
    50                  55                  60                  


Leu Gly Ala Glu Cys Pro Ser Gln Pro Pro Leu His Gly Ile His Ile 
65                  70                  75                  80  


Ala Asp Asn Asn Pro Phe Asn Leu Leu Arg Ile Pro Gly Ser Val Ser 
                85                  90                  95      


Arg Glu Ala Ser Gly Leu Ala Glu Gly Arg Phe Pro Pro Thr Pro Pro 
            100                 105                 110         


Leu Phe Ser Pro Pro Pro Arg His His Leu Asp Pro His Arg Ile Glu 
        115                 120                 125             


Arg Leu Gly Ala Glu Glu Met Ala Leu Ala Thr His His Pro Ser Ala 
    130                 135                 140                 


Phe Asp Arg Val Leu Arg Leu Asn Pro Met Ala Met Glu Pro Pro Ala 
145                 150                 155                 160 


Met Asp Phe Ser Arg Arg Leu Arg Glu Leu Ala Gly Asn Thr Ser Ser 
                165                 170                 175     


Pro Pro Leu Ser Pro Gly Arg Pro Ser Pro Met Gln Arg Leu Leu Gln 
            180                 185                 190         


Pro Phe Gln Pro Gly Ser Lys Pro Pro Phe Leu Ala Thr Pro Pro Leu 
        195                 200                 205             


Pro Pro Leu 
    210     


<210>  7735
<211>  893
<212>  DNA
<213>  Homosapiens

<400>  7735
tctgggcata ttgaaggagc acggagctgt tgggaaaagt tgcaatgcta acatagacct     60

ccactgagag aatttcagaa tcatttggta gttgagaagc gcctacttca tgcggaggcc    120

ccgtgggagg agtggaagag ttggcctcag cactggcgag tatcggatgg gagctctgct    180

cacttgataa acttctgcac tggaggggcc tctcctcccc tcgttctgca catggagctc    240

taatccccac gcctgggatg agtgcagaat atgccccgca gggtatttgt aaagatgagc    300

ccagcagcta cacatgtaca acttgcaaac agccattcac cagtgcatgg tttctcttgc    360

aacacgcaca gaacactcat ggattaagaa tctacttaga aagcgaacac ggaagtcccc    420

tgaccccgcg ggttggtatc ccttcaggac taggtgcaga atgtccttcc cagccacctc    480

tccatgggat tcatattgca gacaataacc cctttaacct gctaagaata ccaggatcag    540

tatcgagaga ggcttccggc ctggcagaag ggcgctttcc acccactccc cccctgttta    600

gtccaccacc gagacatcac ttggaccccc accgcataga gcgcctgggg gcggaagaga    660

tggccctggc cacccatcac ccgagtgcct ttgacagggt gctgcggttg aatccaatgg    720

ctatggagcc tcccgccatg gatttctcta ggagacttag agagctggca gggaacacgt    780

ctagcccacc gctgtcccca ggccggccca gccctatgca aaggttactg caaccattcc    840

agccaggtag caagccgccc ttcctggcga cgccccccct ccctcctctg caa           893


<210>  7736
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  7736

Met Ser Ala Glu Tyr Ala Pro Gln Gly Ile Cys Lys Asp Glu Pro Ser 
1               5                   10                  15      


Ser Tyr Thr Cys Thr Thr Cys Lys Gln Pro Phe Thr Ser Ala Trp Phe 
            20                  25                  30          


Leu Leu Gln His Ala Gln Asn Thr His Gly Leu Arg Ile Tyr Leu Glu 
        35                  40                  45              


Ser Glu His Gly Ser Pro Leu Thr Pro Arg Val Gly Ile Pro Ser Gly 
    50                  55                  60                  


Leu Gly Ala Glu Cys Pro Ser Gln Pro Pro Leu His Gly Ile His Ile 
65                  70                  75                  80  


Ala Asp Asn Asn Pro Phe Asn Leu Leu Arg Ile Pro Gly Ser Val Ser 
                85                  90                  95      


Arg Glu Ala Ser Gly Leu Ala Glu Gly Arg Phe Pro Pro Thr Pro Pro 
            100                 105                 110         


Leu Phe Ser Pro Pro Pro Arg His His Leu Asp Pro His Arg Ile Glu 
        115                 120                 125             


Arg Leu Gly Ala Glu Glu Met Ala Leu Ala Thr His His Pro Ser Ala 
    130                 135                 140                 


Phe Asp Arg Val Leu Arg Leu Asn Pro Met Ala Met Glu Pro Pro Ala 
145                 150                 155                 160 


Met Asp Phe Ser Arg Arg Leu Arg Glu Leu Ala Gly Asn Thr Ser Ser 
                165                 170                 175     


Pro Pro Leu Ser Pro Gly Arg Pro Ser Pro Met Gln Arg Leu Leu Gln 
            180                 185                 190         


Pro Phe Gln Pro Gly Ser Lys Pro Pro Phe Leu Ala Thr Pro Pro Leu 
        195                 200                 205             


Pro Pro Leu 
    210     


<210>  7737
<211>  1190
<212>  DNA
<213>  Homosapiens

<400>  7737
agccttggct attatagtgt attaagacat caggttcctc ctttggagga gggaaggcta     60

cagaactaca aacctttcta acaatgcttt aggtttcttc tttagataga tggctggcac    120

ctaaaggact tgggcctggg tttggctgac tcttttatct tttagatcaa gtaagttttc    180

tcattcagct gctgctctga gctacaatgt gtcctcccct catcaccaaa gtatatcctg    240

gtctccaggc tccctgggct cccagtgtct ccctcaaggt acacgagtgc cctggtggtg    300

aaaacaaggt gctaactaac ggtttccgat ttttgagagc ctgtgatttt ggtgtttgcc    360

tttgctgttg aataacctgt gctgtattat tgatgttcat ctttggttta tgagtttatc    420

actggttaac aagcagaatc agaacagtgt aactgatatt ctgattaaaa cgaatgttta    480

atgaaagaaa ataaattgtg atggaaaatg aacagtgtgt aagaaacata actataattt    540

taacctccga gggacctagc actgccctac cgtgacttcc atccatacca tgctaaaagc    600

atgcttcagt ttaaagttgt taatattcag ctgggaaaca gtatccagaa cacaaataaa    660

ttattaagtg catgaacttt ttaggcagta agatgaactg atggggtcca tctgtgagat    720

ccaggggctt tttatttgtg tgtgtcgagc gattctgccc tctccgactt cacagccttt    780

ggtctccggc caactgcatg cataattgat tccacacgca ctatcatttt cttgatgtaa    840

ttgctttact aagatatgat gaaatctaat ggataatttg ctatttgaaa atggtcaaaa    900

aaaatcccct tcattccttc tctctttctc tcctctctct ctcccccaaa ctttacaaga    960

aagggatcct aacaaggtaa aaagtaaaca atttagtcat cacaagcctt attattcagt   1020

ctatccagga gttttgccat gtcggtttat ttaacttcca ggaatgtaaa cactgacaca   1080

gccctagaag cagcaagaaa gattacagta ttagagttaa aaacgtgagc atggaggagc   1140

tgtgctttat actctgctat aataacactt tacattgaaa cataatggta              1190


<210>  7738
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  7738

Met Asp Asn Leu Leu Phe Glu Asn Gly Gln Lys Lys Ser Pro Ser Phe 
1               5                   10                  15      


Leu Leu Ser Phe Ser Pro Leu Ser Leu Pro Gln Thr Leu Gln Glu Arg 
            20                  25                  30          


Asp Pro Asn Lys Val Lys Ser Lys Gln Phe Ser His His Lys Pro Tyr 
        35                  40                  45              


Tyr Ser Val Tyr Pro Gly Val Leu Pro Cys Arg Phe Ile 
    50                  55                  60      


<210>  7739
<211>  1506
<212>  DNA
<213>  Homosapiens

<400>  7739
gcttaaaaaa aagccatgac ggctctccca caattcatct tccctgcgcc atctttgtat     60

tatttctaat ttattttgga tgtcaaaagg cactgatgaa gatattttct ctggagtctc    120

cttctttcta acccggctct cccgatgtga accgagccgt cgtccgcccg ccgccgccgc    180

cgccgccgcc gccgcccgcc ccgcagccca ccatgtctcg ccgcaagcaa ggcaaacccc    240

agcacttaag caaacgggaa ttctcgcccg agcctcttga agccattctt acagatgatg    300

aaccagacca cggcccgttg ggagctccag aaggggatca tgacctcctc acctgtgggc    360

agtgccagat gaacttccca ttgggggaca ttcttatttt tatcgagcac aaacggaaac    420

aatgcaatgg cagcctctgc ttagaaaaag ctgtggataa gccaccttcc ccttcaccaa    480

tcgagatgaa aaaagcatcc aatcccgtgg aggttggcat ccaggtcacg ccagaggatg    540

acgattgttt atcaacgtca tctagaggaa tttgccccaa acaggaacac atagcagctc    600

agactgaact ggaggatgta tttgtgtacc ttatggtgta attgtaaatg agactataaa    660

ttatagtatg ctattatgac tacttatttt tcttttctct ttatttatgt gattctgaat    720

aaaaacgact gacttctgaa gtgaattttc agcatggcag ttaaaacaaa aaaacaccac    780

taccacaaaa aacaatatac tggtgaacat tttacttacc ttcaaaatcc agagagtaga    840

gaatattgtt ttctaataag tacctaggat tttcataggg agcctatgtt tgtgaggcca    900

ctatccaaag actaatgttc atgaaactgg gagtcctata tacaagctgt atttgtaaat    960

aagacagaga aaggttgtga actggcagct tggatgtttt gtcaaagtac aatgtcagag   1020

aaactctttc taagacaaat tgtaaataga actgtcacag tgattgcatg attgagccgc   1080

agaagtgtcc tacaattgtt ggcattgtca ggacttttga aagcttaatt aaacacagtg   1140

gcccgcatgg ctgctaaact tactaaggaa agccaaaagg aaaaaaaaaa tatatctaaa   1200

atgtagaaga tcctaaagat cccaaacttc ttcagacatt acccttgtgg tgacacagaa   1260

aagatgcatt gtgcattttc ctagtcatct tttataaata atgttttgag aataggtcca   1320

cgtgatatga agatcatcct gtgtgtgatg tggagattgt gttagttttt ctgtctcctg   1380

ctgttacaga cagttaatgt aaaaatggcc ttttattgga aacacaaata tgtattcact   1440

tcaagaacag gagcagaggg ggacaaagtt tccctcccgt tctctgtgtt tattctgtga   1500

aagctt                                                              1506


<210>  7740
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  7740

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Ala Gln Thr Glu Leu Glu Asp Val Phe Val Tyr Leu Met Val 
    130                 135                 140         


<210>  7741
<211>  408
<212>  DNA
<213>  Homosapiens

<400>  7741
tgaacctcaa ctctaccaac tgtgaattct acattcagca aacttagttt aatctgtgaa     60

gactaagtca ttctcacatt tctgggaatt aaggaaatct aaaattaatg catccatcat    120

tcaattctat gagctcccag ttcgcctcgt cgccatgcct cggaaaattg aggaaatcaa    180

ggattttctg ctcacagtcc gatgaaagga tgccaaatcc gtcaagatca agaaaaataa    240

ggacaatgtg aagtttaaag tttgacacag caaatacctt tacaccctgg tcatcactga    300

caaagagaag gcagataaac tgtagtccct gccccctggt ttggcagtga aggaactaaa    360

atgaaccaga cacactgatt tgtgctgtat taaaatacta aaaatcct                 408


<210>  7742
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  7742

Met His Pro Ser Phe Asn Ser Met Ser Ser Gln Phe Ala Ser Ser Pro 
1               5                   10                  15      


Cys Leu Gly Lys Leu Arg Lys Ser Arg Ile Phe Cys Ser Gln Ser Asp 
            20                  25                  30          


Glu Arg Met Pro Asn Pro Ser Arg Ser Arg Lys Ile Arg Thr Met 
        35                  40                  45          


<210>  7743
<211>  632
<212>  DNA
<213>  Homosapiens

<400>  7743
cagtggactc gggttataat taccaacaga ggagagaata actataagtt attttgatgt     60

aaaaagcata ttatcctaag ccaacataat aacacagttt ttatgaagca caataattac    120

tttgaagact cacagaagtg catttttcta aaagaaggag attctcatac agaaacagat    180

taacagaaac agaaacagca acactagaga acagcaaaat agtaacattt caaatagtaa    240

catttcaaga aaatatatac accttcacag tatgtggtgg tatccactta ctgtctactg    300

cctccataac tcctaaagtc ttctgaagat ttattaatgc tttgaatata tgagccaccg    360

tttcttttca cagccttttc acaactggga attctttaga gaaaggcaat cttacctcat    420

ttacttactt catcagtaat gccattacta tgcctaccta agaagaaaat atatcatgtg    480

gcagaggact agaaagaaaa aacaacaaca aaaggctgtg aagatttgat catatgccta    540

cgtgtgtggt gaatacaata tttctttaat cgcaatcagg aatataaatc ttattttgat    600

gctatgacat aataaagtgc attattttcc tg                                  632


<210>  7744
<211>  66
<212>  PRT
<213>  Homosapiens

<400>  7744

Arg Leu Thr Glu Val His Phe Ser Lys Arg Arg Arg Phe Ser Tyr Arg 
1               5                   10                  15      


Asn Arg Leu Thr Glu Thr Glu Thr Ala Thr Leu Glu Asn Ser Lys Ile 
            20                  25                  30          


Val Thr Phe Gln Ile Val Thr Phe Gln Glu Asn Ile Tyr Thr Phe Thr 
        35                  40                  45              


Val Cys Gly Gly Ile His Leu Leu Ser Thr Ala Ser Ile Thr Pro Lys 
    50                  55                  60                  


Val Phe 
65      


<210>  7745
<211>  1006
<212>  DNA
<213>  Homosapiens

<400>  7745
acttatcttt agagacacat ttatatcaga aaatttaact tgatgattaa aaaaattggt     60

gaaatacgtg tagacttttg taactggatt atagtttcat ctaagaactc actaaaaata    120

tattgaactt caggaagaga tttttaaatg gctttggtaa gccatttaaa agccttattt    180

tcccaaacga attagtgttg gtgtgtggat gaggaacttt gctgttattc tgtgagcatt    240

acctgataag aactaatcag atgacagatg gaatctgaag cttgttctga tgaatttttg    300

aggctggaat gcaatggcgt gattatagct caatgcatct tcatctccct gggctcaagc    360

aatcttccaa gctcagcctc ccaagtagct ggaactacag gtaggaccaa ctccactttg    420

aactaggtcc tgttgaaaag gctgttcata aaccttacca gccagtagct cctgtccttt    480

cttgatggat gcagaagatg aaacatcctg gctagaaaac aaaatggcca tgattttgaa    540

gagatgaagt ttcaggacaa ctctgcactc tgaaacattc tgaaacagaa atggaaggtg    600

tgtgtgctgc atcagagcaa tgagctagag caacattaga gaattagcaa catagagaag    660

tgaggtgagg tgtaaaggaa ggacagtcat ctttgatcag ctgttcttgg cccaaacctg    720

ccatatccta acctctggtt ttcataaatg tgtgaagttt gaaggcattt tggcaaaaat    780

ctcaactccc gtaatcacat gaaatgctgt ttcttctcca agggcaggaa attcaaaggc    840

tacatatgta gggttgccca gtgggaatct gagactctag aaactacatc ctgcttttgc    900

atatatcaag attattttgg tgccaaaaag taggtattaa ataataaatt gagttaattg    960

taagtaaaac aaagttaatt ttggtgtttg gcatgaccat tgaacc                  1006


<210>  7746
<211>  52
<212>  PRT
<213>  Homosapiens

<400>  7746

Met Glu Ser Glu Ala Cys Ser Asp Glu Phe Leu Arg Leu Glu Cys Asn 
1               5                   10                  15      


Gly Val Ile Ile Ala Gln Cys Ile Phe Ile Ser Leu Gly Ser Ser Asn 
            20                  25                  30          


Leu Pro Ser Ser Ala Ser Gln Val Ala Gly Thr Thr Gly Arg Thr Asn 
        35                  40                  45              


Ser Thr Leu Asn 
    50          


<210>  7747
<211>  1102
<212>  DNA
<213>  Homosapiens

<400>  7747
aagagatacc agaagggaaa ctgggaagct ggaggagaag gggagaggac catgccttcc     60

ctagacaaaa gacaaagcct tttgcttctg ctataaatag gacaccctca ggaaagctgg    120

agcttctaat tcttccagtg atggaactca gcatatgtct gaggagcaga gaattcagaa    180

gctcccatgg gcctcccaca gctggaatct aaaacaacca cagaagtctc agaaaagaga    240

atataaaagc atacaacaaa ataaaggact cataagagta cagggatcac atacatgaag    300

ttgaacaatg ttcggtttta attcttcaca attatcattt gtaagattgt aggcattggc    360

catggaaccc caagtctcca gccatctcca gttctctgca ggcactgaat gtatgtgcta    420

aggcaagcca tctgcagctg ctgcttgaag ggaggtacag atacaacagt tggaaacctt    480

ggtcaccaca gcagaggtgt ggggccaatc cacaatgcag ttggagcatg ttaacttatg    540

gatgaaatga cagagaagac acagctgctt cagcgctctc tccatgcttg caggaaacca    600

tctaccacca ctcaggtttc cagcggagcc catccgagca gcacagctgc cactgggtac    660

cacaacccat gttgcagcca cgtggctggc ccagaagcag cagggaatga aggctcactc    720

acctcgggat cctcttcgta atgccagttg tcggttctaa ctgaggtgcg aggggagttg    780

gtgggcaagt ggcagttggc ttagaattac aatcaggaga aaggaatgtt cttttgctaa    840

tgaaagagga gaaattggca atgttccagt cccaagtcta ggcctcggga ggcttgcatt    900

ttgccaaatt atgatcccct tctcagctgc tgctctttca gcatggacgc tatcacaaac    960

acatggaaaa tggccttccc tagttaatcc cagccaaacc aaacccaggt gcaaactaga   1020

gccacacagc caaacccacc ctacaccaac cattcccagc tgaactgtat ccatgagaat   1080

aaattattgt ggtttttcag gc                                            1102


<210>  7748
<211>  67
<212>  PRT
<213>  Homosapiens

<400>  7748

Met Asp Glu Met Thr Glu Lys Thr Gln Leu Leu Gln Arg Ser Leu His 
1               5                   10                  15      


Ala Cys Arg Lys Pro Ser Thr Thr Thr Gln Val Ser Ser Gly Ala His 
            20                  25                  30          


Pro Ser Ser Thr Ala Ala Thr Gly Tyr His Asn Pro Cys Cys Ser His 
        35                  40                  45              


Val Ala Gly Pro Glu Ala Ala Gly Asn Glu Gly Ser Leu Thr Ser Gly 
    50                  55                  60                  


Ser Ser Ser 
65          


<210>  7749
<211>  1178
<212>  DNA
<213>  Homosapiens

<400>  7749
ggggctaggc gtggccgacc tcacactctc cttgggcagg acctgctgca gctgctctcg     60

gggttggagg ggaggttcct aggtcaatgg agttgtgtac ctaggaggat tatggctgcc    120

tctgctgagt catgcagatt gtcaggaagt gtgagaaagc cagcagtcac cggcctcacc    180

cagccaccct gccgccatta acagcactag gcaggcagtg cgcagagctg agaacttgcc    240

ccaggttacc cgcctcccag ctgctaaaca aaagggaggc ttttcagctg gttcaaattg    300

ttacaaagtt cagctagaga tttgctttta cctgcggcgt tttccccata ccactggctg    360

ccctcccgaa gaattcctgt gatgccaggc aggaatggcc tggttggaga ccagctagct    420

cccagggcct ttcccgctgc ttcctctacc cctgtatttc gctgggctct ctaaatggat    480

tcagctccag aggaggaaaa ccttgagacc ctgagacttt cagaaactta ttcacagtta    540

ccaaagctga aaatgtttgt ggcagggagt gggacatccg gcttcagagc aggaactttc    600

attgcaccag tgatgaaaaa gagaatgaaa tgtgggtgac gttgagaaag gcaagaagat    660

ttttgttcag aagtgtgccc agtgcctaaa agggaggcaa gcacaagact gggcctaacc    720

tccatggtct ctttgggctg aagactggtc aggccattgg attctcttac aaagatgcca    780

gtaagaacaa agagatcacc tggggagagg atacagtgat ggagcatttg cagaatccca    840

agaactacat ccctggaaca aaaatgatct ttgctggcat tcagaagaag gcagaaaggg    900

cagacttgat agcttatctc aaaaaaagct actcatgagt aataattggc cactgcctta    960

tttattacaa aacagaaatg tctcatgact tttctatgtg taccatactt taatagatct   1020

catacaccag aattcagatc atgaatgact gacagaatat tttactgggc aatcctgatt   1080

taaaactaag actggcttgt ggttaaatga atgtgttcag tttttgaatt ttaatagtaa   1140

ttccaattca gtaaatgcta tcactgttta ccccttct                           1178


<210>  7750
<211>  54
<212>  PRT
<213>  Homosapiens

<400>  7750

Met Asp Ser Ala Pro Glu Glu Glu Asn Leu Glu Thr Leu Arg Leu Ser 
1               5                   10                  15      


Glu Thr Tyr Ser Gln Leu Pro Lys Leu Lys Met Phe Val Ala Gly Ser 
            20                  25                  30          


Gly Thr Ser Gly Phe Arg Ala Gly Thr Phe Ile Ala Pro Val Met Lys 
        35                  40                  45              


Lys Arg Met Lys Cys Gly 
    50                  


<210>  7751
<211>  3775
<212>  DNA
<213>  Homosapiens

<400>  7751
gctgaaggaa gctacaatca tccaagtggg aagtaatgtc taccgatgtt ctgatttaag     60

tgaatgaagg tcttctttcc acctcgggaa atcttgaggg ttatgtaaca gcagctttga    120

aaggcttgtg agatgtactt tgtgctagtc catctcaaat cttcaccggc tgtaccaaga    180

acagaaaaaa aaaggaattt gagacgggat ctcagcatgt ttgccaggat ggtctcagtc    240

tcttgacctc gtgatccgcc taccttggcc tcccaaagtg ttggaattac aggtgtgagc    300

cactgcgccc agccatcaga ggtgactaca cttgtcaaca caagcaacaa aggcccatct    360

ggtaaaaaga aagggaggtc aaagaaagcc catgtactag ctgcctctgt agagcaagcc    420

actcagaatt tcctggaaaa gggtgaacag atcgctaagg agagtcaaga tctcaaagaa    480

gagttggtgg ctgctgtaga ggatgtgcgc aaacaaggtg agacgatgcg gatcgcctcc    540

tccgagtttg cagatgaccc ttgctcgtcg gtaaagcgcg gcaccatggt acgggcggca    600

agggctttgc tctccgcggt gacacgctta ctcatcctgg cggacatggc agatgtcatg    660

agacttttat cccatctgaa aattgtggaa gaggccctgg aagctgtcaa aaatgctaca    720

aatgagcaag accttgcaaa ccgttttaaa gagtttggga aagagatggt gaaacttaac    780

tatgtagcag caagaagaca acaggagctg aaggatcctc actgtcggga tgagatggca    840

gccgcccgag gggctctgaa gaagaatgcc acaatgctgt acacggcctc tcaagcattt    900

ctccgccacc cagatgtcgc cgctacgaga gccaaccgag attatgtgtt caaacaagtc    960

caggaggcca tcgccggcat ctccaatgct gctcaagcta cctcgcccac tgacgaagcc   1020

aagggccaca cgggcatcgg cgagctggct gcggctctta atgagtttga caataagatt   1080

atcctggacc ccatgacgtt cagcgaggcc aggttccggc cgtccctgga ggagaggctg   1140

gagagcagca tcatcagcgg cgcagcgctg atggccgact cctcctgcac gcgagacgac   1200

cggcgcgaga ggatcgtggc ggagtgcaac gccgtgcggc aggcgctcca ggacctgctc   1260

agcgagtaca tgaataatag cttcggaaag cagtgatgga tcacatatct gactctttcc   1320

tggaaaccaa tgttcctttg ctagttctca ttgaggctgc aaagagcgga aatgaaaagg   1380

aagtgaaaga atatgcccaa gttttccgtg agcatgccaa caaactggta gaggttgcca   1440

atttggcctg ttccatctcc aacaatgaag aaggggtgaa attagttcgg atggcagcca   1500

cccagattga cagcctgtgt ccccaggtca tcaatgccgc tctgacactg gctgcccggc   1560

cacagagcaa agttgctcag gataacatgg acgtcttcaa agaccagtgg gagaagcagg   1620

tccgagtgtt gacagaggcc gtggatgaca tcacctcagt ggatgacttc ctctctgtct   1680

cagaaaatca catcttggag gatgtgaaca agtgtgtgat agccctccaa gagggcgatg   1740

tggacactct ggaccggact gcaggggcca tcaggggccg ggcagctcga gtcatacaca   1800

tcatcaatgc tgagatggag aactatgaag ctggggttta tactgagaag gtgttggaag   1860

ctacaaaatt gctttctgaa acagtgatgc cacgcttcgc tgaacaagta gaggttgcca   1920

ttgaagccct gagtgccaac gttcctcaac cgtttgagga gaatgagttc atcgatgcct   1980

ctcgcctggt gtatgatggc gttcgggaca tcagaaaggc tgtgctgatg atcaggaccc   2040

cagaagaact agaggatgat tctgactttg agcaggaaga ttatgatgtg cgtagcagga   2100

caagtgttca gactgaggat gaccagctca ttgcagggca gagcgcacgg gccatcatgg   2160

cgcaactacc gcaggaggag aaggcaaaaa tagctgagca ggtggagata ttccatcaag   2220

agaaaagcaa gctggatgca gaagtggcca aatgggacga cagcggcaat gatatcattg   2280

tactggccaa gcagatgtgt atgatcatga tggaaatgac agacttcaca agaggcaaag   2340

gcccattgaa aaatacatct gatgtcatta atgctgccaa gaaaattgcc gaagcaggtt   2400

ctcgaatgga caaattagct cgtgctgtgg ctgatcagtg tcctgattca gcatgtaagc   2460

aggatttatt agcctacctt caacgaattg ccttgtattg ccatcagctt aatatctgca   2520

gcaaggtgaa ggcagaagtg cagaatctgg gaggagagct cattgtgtca gggctggaca   2580

gtgccacatc gcttatccag gcagctaaaa acctgatgaa tgctgttgtc ctcacggtga   2640

aagcatccta tgtggcctca accaaatacc agaaggtcta tgggacagca gctgtcaact   2700

cacctgttgt gtcttggaag atgaaggctc cagagaagaa gccccttgtg aagagagaaa   2760

agcctgaaga attccagaca cgagttcgac gaggttctca gaagaaacac atttcgcctg   2820

tacaggcttt aagtgaattc aaagcaatgg attccttcta ggacgatagg ttttaacaag   2880

aaagcttttt ctttcttttc tttctttctt tttcttttta attccatttt tgtatgcata   2940

cctgccagct cgtatgcctc tggcatgggg aaattaaggg aacagtgtct gtttgcatgt   3000

aagatgagat gagatcaata ctactgatcc atctgtagcc tgggaaggag acaggacatt   3060

cctgtactaa ggtggcacag agctgtcctt tgcaacattc tcataaaatt gggcacagag   3120

ttcgcattgg cgcaatattt atgggagtgg gagggatggg gaaaataaac ttaactctac   3180

aaaagcaaac tctaatgcat gcaagaatca ttaggttggc aggtatatgc ataagtgaaa   3240

aatctggaag tgtaatggta gaacataaaa cttgtattgc ttctgtttca gtgcaaaaat   3300

gtactagcca atacgcttaa gtgtgtggcc catgaattga acaatttaac cttgaagtct   3360

atatccgtga tattatgtcg atttttaact gaggggaaat taactagtcc agcctaaaat   3420

gcttctttta atctgcattc tgtttcctct tctagttgtg ccattactag tgatcatgtt   3480

tttttccccc ctttaatgaa aacaataaac atctatttga gacaattaaa atccttctgg   3540

gggcactgga agcacaatac ggtgaccaat cttgctttca tttttttttc tttttaattt   3600

gaaccatgat tttgctagaa atagaaggcc cagtggtgga atattagagg gaaggaaact   3660

gacaacgtgt gaaagttaga ggcaaataca taggtgtagc ttggagtgct ggtatctaat   3720

ataccattgt attcactaac taactcaaaa taaacacatt taatcttgac atctc        3775


<210>  7752
<211>  521
<212>  PRT
<213>  Homosapiens

<400>  7752

Met Asp His Ile Ser Asp Ser Phe Leu Glu Thr Asn Val Pro Leu Leu 
1               5                   10                  15      


Val Leu Ile Glu Ala Ala Lys Ser Gly Asn Glu Lys Glu Val Lys Glu 
            20                  25                  30          


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Val Glu Val Ala 
        35                  40                  45              


Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val 
    50                  55                  60                  


Arg Met Ala Ala Thr Gln Ile Asp Ser Leu Cys Pro Gln Val Ile Asn 
65                  70                  75                  80  


Ala Ala Leu Thr Leu Ala Ala Arg Pro Gln Ser Lys Val Ala Gln Asp 
                85                  90                  95      


Asn Met Asp Val Phe Lys Asp Gln Trp Glu Lys Gln Val Arg Val Leu 
            100                 105                 110         


Thr Glu Ala Val Asp Asp Ile Thr Ser Val Asp Asp Phe Leu Ser Val 
        115                 120                 125             


Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile Ala Leu 
    130                 135                 140                 


Gln Glu Gly Asp Val Asp Thr Leu Asp Arg Thr Ala Gly Ala Ile Arg 
145                 150                 155                 160 


Gly Arg Ala Ala Arg Val Ile His Ile Ile Asn Ala Glu Met Glu Asn 
                165                 170                 175     


Tyr Glu Ala Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr Lys Leu 
            180                 185                 190         


Leu Ser Glu Thr Val Met Pro Arg Phe Ala Glu Gln Val Glu Val Ala 
        195                 200                 205             


Ile Glu Ala Leu Ser Ala Asn Val Pro Gln Pro Phe Glu Glu Asn Glu 
    210                 215                 220                 


Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Val Arg Asp Ile Arg 
225                 230                 235                 240 


Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Glu Asp Asp Ser 
                245                 250                 255     


Asp Phe Glu Gln Glu Asp Tyr Asp Val Arg Ser Arg Thr Ser Val Gln 
            260                 265                 270         


Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile Met 
        275                 280                 285             


Ala Gln Leu Pro Gln Glu Glu Lys Ala Lys Ile Ala Glu Gln Val Glu 
    290                 295                 300                 


Ile Phe His Gln Glu Lys Ser Lys Leu Asp Ala Glu Val Ala Lys Trp 
305                 310                 315                 320 


Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys Met 
                325                 330                 335     


Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu Lys 
            340                 345                 350         


Asn Thr Ser Asp Val Ile Asn Ala Ala Lys Lys Ile Ala Glu Ala Gly 
        355                 360                 365             


Ser Arg Met Asp Lys Leu Ala Arg Ala Val Ala Asp Gln Cys Pro Asp 
    370                 375                 380                 


Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala Leu 
385                 390                 395                 400 


Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val Gln 
                405                 410                 415     


Asn Leu Gly Gly Glu Leu Ile Val Ser Gly Leu Asp Ser Ala Thr Ser 
            420                 425                 430         


Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Leu Thr Val 
        435                 440                 445             


Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Val Tyr Gly Thr 
    450                 455                 460                 


Ala Ala Val Asn Ser Pro Val Val Ser Trp Lys Met Lys Ala Pro Glu 
465                 470                 475                 480 


Lys Lys Pro Leu Val Lys Arg Glu Lys Pro Glu Glu Phe Gln Thr Arg 
                485                 490                 495     


Val Arg Arg Gly Ser Gln Lys Lys His Ile Ser Pro Val Gln Ala Leu 
            500                 505                 510         


Ser Glu Phe Lys Ala Met Asp Ser Phe 
        515                 520     


<210>  7753
<211>  3850
<212>  DNA
<213>  Homosapiens

<400>  7753
gctgaaggaa gctacaatca tccaagtggg aagtaatgtc taccgatgtt ctgatttaag     60

tgaatgaagg tcttctttcc acctcgggaa atcttgaggg ttatgtaaca gcagctttga    120

aaggcttgtg agatgtactt tgtgctagtc catctcaaat cttcaccggc tgtaccaaga    180

acagaaaaaa aaaggaattt gagacgggat ctcagcatgt ttgccaggat ggtctcagtc    240

tcttgacctc gtgatccgcc taccttggcc tcccaaagtg ttggaattac aggtgtgagc    300

cactgcgccc agccatcaga ggtgactaca cttgtcaaca caagcaacaa aggcccatct    360

ggtaaaaaga aagggaggtc aaagaaagcc catgtactag ctgcctctgt agagcaagcc    420

actcagaatt tcctggaaaa gggtgaacag atcgctaagg agagtcaaga tctcaaagaa    480

gagttggtgg ctgctgtaga ggatgtgcgc aaacaaggtg agacgatgcg gatcgcctcc    540

tccgagtttg cagatgaccc ttgctcgtcg gtaaagcgcg gcaccatggt acgggcggca    600

agggctttgc tctccgcggt gacacgctta ctcatcctgg cggacatggc agatgtcatg    660

agacttttat cccatctgaa aattgtggaa gaggccctgg aagctgtcaa aaatgctaca    720

aatgagcaag accttgcaaa ccgttttaaa gagtttggga aagagatggt gaaacttaac    780

tatgtagcag caagaagaca acaggagctg aaggatcctc actgtcggga tgagatggca    840

gccgcccgag gggctctgaa gaagaatgcc acaatgctgt acacggcctc tcaagcattt    900

ctccgccacc cagatgtcgc cgctacgaga gccaaccgag attatgtgtt caaacaagtc    960

caggaggcca tcgccggcat ctccaatgct gctcaagcta cctcgcccac tgacgaagcc   1020

aagggccaca cgggcatcgg cgagctggct gcggctctta atgagtttga caataagatt   1080

atcctggacc ccatgacgtt cagcgaggcc aggttccggc cgtccctgga ggagaggctg   1140

gagagcagca tcatcagcgg cgcagcgctg atggccgact cctcctgcac gcgagacgac   1200

cggcgcgaga ggatcgtggc ggagtgcaac gccgtgcggc aggcgctcca ggacctgctc   1260

agcgagtaca tgaataatag cttcggaaag cagtgatgga tcacatatct gactctttcc   1320

tggaaaccaa tgttcctttg ctagttctca ttgaggctgc aaagagcgga aatgaaaagg   1380

aagtgaaaga atatgcccaa gttttccgtg agcatgccaa caaactggta gaggttgcca   1440

atttggcctg ttccatctcc aacaatgaag aaggggtgaa attagttcgg atggcagcca   1500

cccagattga cagcctgtgt ccccaggtca tcaatgccgc tctgacactg gctgcccggc   1560

cacagagcaa agttgctcag gataacatgg acgtcttcaa agaccagtgg gagaagcagg   1620

tccgagtgtt gacagaggcc gtggatgaca tcacctcagt ggatgacttc ctctctgtct   1680

cagaaaatca catcttggag gatgtgaaca agtgtgtgat agccctccaa gagggcgatg   1740

tggacactct ggaccggact gcaggggcca tcaggggccg ggcagctcga gtcatacaca   1800

tcatcaatgc tgagatggag aactatgaag ctggggttta tactgagaag gtgttggaag   1860

ctacaaaatt gctttctgaa acagtgatgc cacgcttcgc tgaacaagta gaggttgcca   1920

ttgaagccct gagtgccaac gttcctcaac cgtttgagga gaatgagttc atcgatgcct   1980

ctcgcctggt gtatgatggc gttcgggaca tcagaaaggc tgtgctgatg atcaggaccc   2040

cagaagaact agaggatgat tctgactttg agcaggaaga ttatgatgtg cgtagcagga   2100

caagtgttca gactgaggat gaccagctca ttgcagggca gagcgcacgg gccatcatgg   2160

cgcaactacc gcaggaggag aaggcaaaaa tagctgagca ggtggagata ttccatcaag   2220

agaaaagcaa gctggatgca gaagtggcca aatgggacga cagcggcaat gatatcattg   2280

tactggccaa gcagatgtgt atgatcatga tggaaatgac agacttcaca agaggcaaag   2340

gcccattgaa aaatacatct gatgtcatta atgctgccaa gaaaattgcc gaagcaggtt   2400

ctcgaatgga caaattagct cgtgctgtgg ctgatcagtg tcctgattca gcatgtaagc   2460

aggatttatt agcctacctt caacgaattg ccttgtattg ccatcagctt aatatctgca   2520

gcaaggtgaa ggcagaagtg cagaatctgg gaggagagct cattgtgtca gggctggaca   2580

gtgccacatc gcttatccag gcagctaaaa acctgatgaa tgctgttgtc ctcacggtga   2640

aagcatccta tgtggcctca accaaatacc agaaggtcta tgggacagca gctgtcaact   2700

cacctgttgt gtcttggaag atgaaggctc cagagaagaa gccccttgtg aagagagaaa   2760

agcctgaaga attccagaca cgagttcgac gaggttctca gaagaaacac atttcgcctg   2820

tacaggcttt aagtgaattc aaagcaatgg attccttcta ggacgatagg ttttaacaag   2880

aaagcttttt ctttcttttc tttctttctt tttcttttta attccatttt tgtatgcata   2940

cctgccagct cgtatgcctc tggcatgggg aaattaaggg aacagtgtct gtttgcatgt   3000

aagatgagat gagatcaata ctactgatcc atctgtagcc tgggaaggag acaggacatt   3060

cctgtactaa ggtggcacag agctgtcctt tgcaacattc tcataaaatt gggcacagag   3120

ttcgcattgg cgcaatattt atgggagtgg gagggatggg gaaaataaac ttaactctac   3180

aaaagcaaac tctaatgcat gcaagaatca ttaggttggc aggtatatgc ataagtgaaa   3240

aatctggaag tgtaatggta gaacataaaa cttgtattgc ttctgtttca gtgcaaaaat   3300

gtactagcca atacgcttaa gtgtgtggcc catgaattga acaatttaac cttgaagtct   3360

atatccgtga tattatgtcg atttttaact gaggggaaat taactagtcc agcctaaaat   3420

gcttctttta atctgcattc tgtttcctct tctagttgtg ccattactag tgatcatgtt   3480

tttttccccc ctttaatgaa aacaataaac atctatttga gacaattaaa atccttctgg   3540

gggcactgga agcacaatac ggtgaccaat cttgctttca tttttttttc tttttaattt   3600

gaaccatgat tttgctagaa atagaaggcc cagtggtgga atattagagg gaaggaaact   3660

gacaacgtgt gaaagttaga ggcaaataca taggtgtagc ttggagtgct ggtatctaat   3720

ataccattgt attcactaac taactcaaaa taaacacatt taatcttgac atctcaagta   3780

tgttttcttt tttaattttt taagtatgta cttaataaag attagagcat catcttcctg   3840

aaaattcatt                                                          3850


<210>  7754
<211>  521
<212>  PRT
<213>  Homosapiens

<400>  7754

Met Asp His Ile Ser Asp Ser Phe Leu Glu Thr Asn Val Pro Leu Leu 
1               5                   10                  15      


Val Leu Ile Glu Ala Ala Lys Ser Gly Asn Glu Lys Glu Val Lys Glu 
            20                  25                  30          


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Val Glu Val Ala 
        35                  40                  45              


Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val 
    50                  55                  60                  


Arg Met Ala Ala Thr Gln Ile Asp Ser Leu Cys Pro Gln Val Ile Asn 
65                  70                  75                  80  


Ala Ala Leu Thr Leu Ala Ala Arg Pro Gln Ser Lys Val Ala Gln Asp 
                85                  90                  95      


Asn Met Asp Val Phe Lys Asp Gln Trp Glu Lys Gln Val Arg Val Leu 
            100                 105                 110         


Thr Glu Ala Val Asp Asp Ile Thr Ser Val Asp Asp Phe Leu Ser Val 
        115                 120                 125             


Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile Ala Leu 
    130                 135                 140                 


Gln Glu Gly Asp Val Asp Thr Leu Asp Arg Thr Ala Gly Ala Ile Arg 
145                 150                 155                 160 


Gly Arg Ala Ala Arg Val Ile His Ile Ile Asn Ala Glu Met Glu Asn 
                165                 170                 175     


Tyr Glu Ala Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr Lys Leu 
            180                 185                 190         


Leu Ser Glu Thr Val Met Pro Arg Phe Ala Glu Gln Val Glu Val Ala 
        195                 200                 205             


Ile Glu Ala Leu Ser Ala Asn Val Pro Gln Pro Phe Glu Glu Asn Glu 
    210                 215                 220                 


Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Val Arg Asp Ile Arg 
225                 230                 235                 240 


Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Glu Asp Asp Ser 
                245                 250                 255     


Asp Phe Glu Gln Glu Asp Tyr Asp Val Arg Ser Arg Thr Ser Val Gln 
            260                 265                 270         


Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile Met 
        275                 280                 285             


Ala Gln Leu Pro Gln Glu Glu Lys Ala Lys Ile Ala Glu Gln Val Glu 
    290                 295                 300                 


Ile Phe His Gln Glu Lys Ser Lys Leu Asp Ala Glu Val Ala Lys Trp 
305                 310                 315                 320 


Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys Met 
                325                 330                 335     


Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu Lys 
            340                 345                 350         


Asn Thr Ser Asp Val Ile Asn Ala Ala Lys Lys Ile Ala Glu Ala Gly 
        355                 360                 365             


Ser Arg Met Asp Lys Leu Ala Arg Ala Val Ala Asp Gln Cys Pro Asp 
    370                 375                 380                 


Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala Leu 
385                 390                 395                 400 


Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val Gln 
                405                 410                 415     


Asn Leu Gly Gly Glu Leu Ile Val Ser Gly Leu Asp Ser Ala Thr Ser 
            420                 425                 430         


Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Leu Thr Val 
        435                 440                 445             


Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Val Tyr Gly Thr 
    450                 455                 460                 


Ala Ala Val Asn Ser Pro Val Val Ser Trp Lys Met Lys Ala Pro Glu 
465                 470                 475                 480 


Lys Lys Pro Leu Val Lys Arg Glu Lys Pro Glu Glu Phe Gln Thr Arg 
                485                 490                 495     


Val Arg Arg Gly Ser Gln Lys Lys His Ile Ser Pro Val Gln Ala Leu 
            500                 505                 510         


Ser Glu Phe Lys Ala Met Asp Ser Phe 
        515                 520     


<210>  7755
<211>  550
<212>  DNA
<213>  Homosapiens

<400>  7755
gagacgggat ctcagcatgt ttgccaggat ggtctcagtc tcttgacctc gtgatccgcc     60

taccttggcc tcccaaagtg ttggaattac aggtgtgagc cactgcgccc agccatcaga    120

acaaaatata cagctggatg tttgtcacaa ttctaatgtc cctgcaaaga tgagatgcat    180

gaatcacaca gcaatctcat caaaaagccc tagcactacc tctcagtatc ttcatatcct    240

tcaccgcagc aactttgctt tgtacactct gtctcctgcc aagagagccc agggaaggta    300

atgtctcctg gatcgtatga aatgtttctg taacggtcac tgtaactcac accttgattt    360

ttaccaggtc gctggcaagt gcgatggatt gtaattgctg cacattcatg agggcttctc    420

aaggttaccc ggtgagggtt aatgttcagt tcatccacca gacttatgag gcggaagaga    480

aaatctctat tagttattct gcagcattaa caaaaaatta gagaacatag tctgtgctct    540

taaaagaagc                                                           550


<210>  7756
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  7756

Met Arg Cys Met Asn His Thr Ala Ile Ser Ser Lys Ser Pro Ser Thr 
1               5                   10                  15      


Thr Ser Gln Tyr Leu His Ile Leu His Arg Ser Asn Phe Ala Leu Tyr 
            20                  25                  30          


Thr Leu Ser Pro Ala Lys Arg Ala Gln Gly Arg 
        35                  40              


<210>  7757
<211>  751
<212>  DNA
<213>  Homosapiens

<400>  7757
taagaagtgc cctccaccat gattgtgtga ccttccccag ccacctggaa ctaacaaaat     60

atacagctgg atgtttgtca caattctaat gtccctgcaa agatgagatg catgaatcac    120

acagcaatct catcaaaaag gaatttctgg aaggcatagg agaagagaat cctggaaaaa    180

gcaagaagca ggaagataag aggcaaagaa gaagagagcc ccacccactg gggcaagctg    240

gggccccaga tgatgaaact gtggcccaga aagtttaagg gatgtgtcaa atgtcacaca    300

gctcacagat ccagggacat ggcttaaatc cagatatctt gattctaact tcagttgagg    360

aagagaaaga gtgctgcccc acgctgcctg atttacaacg tgaagtgaaa tctttgaaaa    420

gaaaaataag acaatgtcac tcaagctctt atctgaggat ttcctgggtt tgaagacaga    480

gctcaaactc atacaagggg tcatctgagt ctgcagatag gcttgcttta tgctgctccg    540

tcagatctct tctaaagatt agtgcgcaat tctggacatt acattttaat ggtaacatgg    600

attcaactaa agggtaagca aaggacaccg acaggaatag ggagggtgcc atttatagag    660

aaaagactga gaggtccata ttgttatttt acctgaaaga tataataaac agaggatgct    720

gtttatcatg agtagatgct gatgagaaaa t                                   751


<210>  7758
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  7758

Met His Glu Ser His Ser Asn Leu Ile Lys Lys Glu Phe Leu Glu Gly 
1               5                   10                  15      


Ile Gly Glu Glu Asn Pro Gly Lys Ser Lys Lys Gln Glu Asp Lys Arg 
            20                  25                  30          


Gln Arg Arg Arg Glu Pro His Pro Leu Gly Gln Ala Gly Ala Pro Asp 
        35                  40                  45              


Asp Glu Thr Val Ala Gln Lys Val 
    50                  55      


<210>  7759
<211>  734
<212>  DNA
<213>  Homosapiens

<400>  7759
cagagttgct tgtgattaaa taaccccaac tgacgtggaa atcaaataaa gcaacaaaga     60

actgcttttt caactaacaa aatatacagc tggatgtttg tcacaattct aatgtccctg    120

caaagatgag atgcatgaat cacacagcaa tctcatcaaa aaggaatttc tggaaggcat    180

aggagaagag aatcctggaa aaagcaagaa gcaggaagat aagaggcaaa gaagaagaga    240

gccccaccca ctggggcaag ctggggcccc agatgatgaa actgtggccc agaaagttta    300

agggatgtgt caaatgtcac acagctcaca gatccaggga catggcttaa atccagatat    360

cttgattcta acttcagttg aggaagagaa agagtgctgc cccacgctgc ctgatttaca    420

acgtgaagtg aaatctttga aaagaaaaat aagacaatgt cactcaagct cttatctgag    480

gatttcctgg gtttgaagac agagctcaaa ctcatacaag gggtcatctg agtctgcaga    540

taggcttgct ttatgctgct ccgtcagatc tcttctaaag attagtgcgc aattctggac    600

attacatttt aatggtaaca tggattcaac taaagggtaa gcaaaggaca ccgacaggaa    660

tagggagggt gccatttata gagaaaagac tgagaggtcc atattgttat tttacctgaa    720

agatataata aaca                                                      734


<210>  7760
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  7760

Met His Glu Ser His Ser Asn Leu Ile Lys Lys Glu Phe Leu Glu Gly 
1               5                   10                  15      


Ile Gly Glu Glu Asn Pro Gly Lys Ser Lys Lys Gln Glu Asp Lys Arg 
            20                  25                  30          


Gln Arg Arg Arg Glu Pro His Pro Leu Gly Gln Ala Gly Ala Pro Asp 
        35                  40                  45              


Asp Glu Thr Val Ala Gln Lys Val 
    50                  55      


<210>  7761
<211>  835
<212>  DNA
<213>  Homosapiens

<400>  7761
atgtcaccac ctacctgctt tatctctttg tcacattttc atctctttct acttcaactt     60

tcctttgatt catccccaaa agctttcccc taggccactt ggcagtattc cctcactagt    120

caaaatctgg tgggtctttc ttgagtgagc tctcagagct gacctccttt tttaagacat    180

ctatttgcat gcaggtggcc atcgatgaca tcaatggttt tgcagtattg agccacattt    240

tggattttac ctagaagatg tgcagaatat aaatgttttc atgagaacaa aatatacagc    300

tggatgtttg tcacaattct aatgtccctg caaagatgag atgcatgaat cacacagcaa    360

tctcatcaaa aagatgatga aactgtggcc cagaaagttt aagggatgtg tcaaatgtca    420

cacagctcac agatccaggg acatggctta aatccagata tcttgattct aacttcagtt    480

gaggaagaga aagagtgctg ccccacgctg cctgatttac aacgtgaagt gaaatctttg    540

aaaagaaaaa taagacaatg tcactcaagc tcttatctga ggatttcctg ggtttgaaga    600

cagagctcaa actcatacaa ggggtcatct gagtctgcag ataggcttgc tttatgctgc    660

tccgtcagat ctcttctaaa gattagtgcg caattctgga cattacattt taatggtaac    720

atggattcaa ctaaagggta agcaaaggac accgacagga atagggaggg tgccatttat    780

agagaaaaga ctgagaggtc catattgtta ttttacctga aagatataat aaaca         835


<210>  7762
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  7762

Met His Glu Ser His Ser Asn Leu Ile Lys Lys Met Met Lys Leu Trp 
1               5                   10                  15      


Pro Arg Lys Phe Lys Gly Cys Val Lys Cys His Thr Ala His Arg Ser 
            20                  25                  30          


Arg Asp Met Ala 
        35      


<210>  7763
<211>  545
<212>  DNA
<213>  Homosapiens

<400>  7763
aagtctcaga gccagcactc aggatgagtg ccaatggaag cctgtccttg gagtccagaa     60

tgaacgtcag aagcaaccca gccacagcag gagactgtcc atgaatgtca tctggctgaa    120

cctaaagttt ccttagacac atgaatgaac acagtcatgc tgtcaggaag aggaaaagga    180

agactgataa ataaacgttc aatttaagcc aatccagtat ctatactgta gacctcagtg    240

aaggctggaa gactaatcca acacaatctg acatcctgat tctttccaat cacctttatg    300

ttccaccctc tcacctctgg atttagatgc actccttcaa ggaccatggg ttctgcaaca    360

gtaccccctc tccattgttc cagctctgac tcagatgggc cctccttgat ggcactccca    420

gcagcacagc cttagcactg catgacttcg gcaacttcac ctatcattct gaaatgggac    480

cccaaaagtt tggaaatccg gacgctaaca gtggaaaggc tgttggagcc acttgttaca    540

caggt                                                                545


<210>  7764
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  7764

Met Phe His Pro Leu Thr Ser Gly Phe Arg Cys Thr Pro Ser Arg Thr 
1               5                   10                  15      


Met Gly Ser Ala Thr Val Pro Pro Leu His Cys Ser Ser Ser Asp Ser 
            20                  25                  30          


Asp Gly Pro Ser Leu Met Ala Leu Pro Ala Ala Gln Pro 
        35                  40                  45  


<210>  7765
<211>  1161
<212>  DNA
<213>  Homosapiens

<400>  7765
agaccagcta gactgagtga tagggcaaga ctccatatct aacaaataaa taaataaaca     60

gaaaaataaa ctttgaataa agccacaaca gataatttgg taaatgtgat gtcatggcat    120

gtcatggatt agcagtaacc cattttccat gggtaataag gtcatcatta tattcaaact    180

gtacaagcta cctaacccaa gaatcacatc actgaattaa caagacaaaa acaaaaacaa    240

aggagagtac cttattgttt taaaacaata gactgtaatt tagaggtcta attcaggagc    300

cttgttacat tgtattgagt ctgagagaag taaaataaaa agtacaccac agattagtaa    360

ttgctgacag tggctgcttc atcaagttct tggaaaacaa aagtgacaaa acggtgtaat    420

cagagcccag aagaacactc agtgcttccc tgctagggta gctagtttag acagtgctga    480

aaccatgacg aagaaggcct gcagcttgtc ctagaaccat gcaagaggga ccattgaagc    540

tgaaggtgga ttgctgttgg gtggaaagga tgtagtcact caaaaatgct gccagaagaa    600

gagcaagaga aaagaacaat agcttctccc gtgagacaat ctcatccctc cactagtgtc    660

ttctcttgga atgatctatt gtgctctgag tgggtagaaa acatgatggc aagtgtatgg    720

tgctgaatca aggtaaaaga ggaaatgatt atgtactcac agagggtgga acataaaggt    780

gattggaaag aatcaggatg tcagattgtg ttggattagt cttccagcct tcactgaggt    840

ctacagtata gatactggat tggcttaaat tgaacgttct gcaaataaga gaaggtatat    900

tcttgtccaa gaggatgtgg tatctacata taggaggaaa gatatacgtg tacatgtggt    960

ggctgaacca tttgattgtg gatcaggata cataagcagc aagttcaaag actgaaggaa   1020

caaggaatat cagctcataa agatgagaaa gaatcagagc aagaactctg gcaactcaaa   1080

agccaaggtg tcttcttacc tccaaacaac catattattt cgttagcaac gattcttaac   1140

cagactgaga ttgctgaagt a                                             1161


<210>  7766
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  7766

Met Leu Pro Glu Glu Glu Gln Glu Lys Arg Thr Ile Ala Ser Pro Val 
1               5                   10                  15      


Arg Gln Ser His Pro Ser Thr Ser Val Phe Ser Trp Asn Asp Leu Leu 
            20                  25                  30          


Cys Ser Glu Trp Val Glu Asn Met Met Ala Ser Val Trp Cys 
        35                  40                  45      


<210>  7767
<211>  3848
<212>  DNA
<213>  Homosapiens

<400>  7767
gagcggcttc gcttccagcc ccgagtgagg cggagaccca ggcgggcggg cagagcaggc     60

ggcaccgcac ctcggccaga ggcggctgca gcagctgctg cccttgtccc tgccgccgcc    120

tctccagtcc cttctgtgat taccactcca gctgctggga acgggcgaga aagaggagga    180

ggcgagaaac tcccaccgac ccacagaggg agcatgactt cggcaacttc acctatcatt    240

ctgaaatggg accccaaaag tttggaaatc cggacgctaa cagtggaaag gctgttggag    300

ccacttgtta cacaggtgac tacacttgtc aacacaagca acaaaggccc atctggtaaa    360

aagaaaggga ggtcaaagaa agcccatgta ctagctgcct ctgtagagca agccactcag    420

aatttcctgg aaaagggtga acagatcgct aaggagagtc aagatctcaa agaagagttg    480

gtggctgctg tagaggatgt gcgcaaacaa ggtgagacga tgcggatcgc ctcctccgag    540

tttgcagatg acccttgctc gtcggtaaag cgcggcacca tggtacgggc ggcaagggct    600

ttgctctccg cggtgacacg cttactcatc ctggcggaca tggcagatgt catgagactt    660

ttatcccatc tgaaaattgt ggaagaggcc ctggaagctg tcaaaaatgc tacaaatgag    720

caagaccttg caaaccgttt taaagagttt gggaaagaga tggtgaaact taactatgta    780

gcagcaagaa gacaacagga gctgaaggat cctcactgtc gggatgagat ggcagccgcc    840

cgaggggctc tgaagaagaa tgccacaatg ctgtacacgg cctctcaagc atttctccgc    900

cacccagatg tcgccgctac gagagccaac cgagattatg tgttcaaaca agtccaggag    960

gccatcgccg gcatctccaa tgctgctcaa gctacctcgc ccactgacga agccaagggc   1020

cacacgggca tcggcgagct ggctgcggct cttaatgagt ttgacaataa gattatcctg   1080

gaccccatga cgttcagcga ggccaggttc cggccgtccc tggaggagag gctggagagc   1140

agcatcatca gcggcgcagc gctgatggcc gactcctcct gcacgcgaga cgaccggcgc   1200

gagaggatcg tggcggagtg caacgccgtg cggcaggcgc tccaggacct gctcagcgag   1260

tacatgaata atactggaag gaaagaaaaa ggagatcctc tcaacattgc gattgataag   1320

atgactaaga aaacaagaga tctaaggaga cagcttcgga aagcagtgat ggatcacata   1380

tctgactctt tcctggaaac caatgttcct ttgctagttc tcattgaggc tgcaaagagc   1440

ggaaatgaaa aggaagtgaa agaatatgcc caagttttcc gtgagcatgc caacaaactg   1500

gtagaggttg ccaatttggc ctgttccatc tccaacaatg aagaaggggt gaaattagtt   1560

cggatggcag ccacccagat tgacagcctg tgtccccagg tcatcaatgc cgctctgaca   1620

ctggctgccc ggccacagag caaagttgct caggataaca tggacgtctt caaagaccag   1680

tgggagaagc aggtccgagt gttgacagag gccgtggatg acatcacctc agtggatgac   1740

ttcctctctg tctcagaaaa tcacatcttg gaggatgtga acaagtgtgt gatagccctc   1800

caagagggcg atgtggacac tctggaccgg actgcagggg ccatcagggg ccgggcagct   1860

cgagtcatac acatcatcaa tgctgagatg gagaactatg aagctggggt ttatactgag   1920

aaggtgttgg aagctacaaa attgctttct gaaacagtga tgccacgctt cgctgaacaa   1980

gtagaggttg ccattgaagc cctgagtgcc aacgttcctc aaccgtttga ggagaatgag   2040

ttcatcgatg cctctcgcct ggtgtatgat ggcgttcggg acatcagaaa ggctgtgctg   2100

atgatcagga ccccagaaga actagaggat gattctgact ttgagcagga agattatgat   2160

gtgcgtagca ggacaagtgt tcagactgag gatgaccagc tcattgcagg gcagagcgca   2220

cgggccatca tggcgcaact accgcaggag gagaaggcaa aaatagctga gcaggtggag   2280

atattccatc aagagaaaag caagctggat gcagaagtgg ccaaatggga cgacagcggc   2340

aatgatatca ttgtactggc caagcagatg tgtatgatca tgatggaaat gacagacttc   2400

acaagaggca aaggcccatt gaaaaataca tctgatgtca ttaatgctgc caagaaaatt   2460

gccgaagcag gttctcgaat ggacaaatta gctcgtgctg tggctgatca gtgtcctgat   2520

tcagcatgta agcaggattt attagcctac cttcaacgaa ttgccttgta ttgccatcag   2580

cttaatatct gcagcaaggt gaaggcagaa gtgcagaatc tgggaggaga gctcattgtg   2640

tcagggctgg acagtgccac atcgcttatc caggcagcta aaaacctgat gaatgctgtt   2700

gtcctcacgg tgaaagcatc ctatgtggcc tcaaccaaat accagaaggt ctatgggaca   2760

gcagctgtca actcacctgt tgtgtcttgg aagatgaagg ctccagagaa gaagcccctt   2820

gtgaagagag aaaagcctga agaattccag acacgagttc gacgaggttc tcagaagaaa   2880

cacatttcgc ctgtacaggc tttaagtgaa ttcaaagcaa tggattcctt ctaggacgat   2940

aggttttaac aagaaagctt tttctttctt ttctttcttt ctttttcttt ttaattccat   3000

ttttgtatgc atacctgcca gctcgtatgc ctctggcatg gggaaattaa gggaacagtg   3060

tctgtttgca tgtaagatga gatgagatca atactactga tccatctgta gcctgggaag   3120

gagacaggac attcctgtac taaggtggca cagagctgtc ctttgcaaca ttctcataaa   3180

attgggcaca gagttcgcat tggcgcaata tttatgggag tgggagggat ggggaaaata   3240

aacttaactc tacaaaagca aactctaatg catgcaagaa tcattaggtt ggcaggtata   3300

tgcataagtg aaaaatctgg aagtgtaatg gtagaacata aaacttgtat tgcttctgtt   3360

tcagtgcaaa aatgtactag ccaatacgct taagtgtgtg gcccatgaat tgaacaattt   3420

aaccttgaag tctatatccg tgatattatg tcgattttta actgagggga aattaactag   3480

tccagcctaa aatgcttctt ttaatctgca ttctgtttcc tcttctagtt gtgccattac   3540

tagtgatcat gtttttttcc cccctttaat gaaaacaata aacatctatt tgagacaatt   3600

aaaatccttc tgggggcact ggaagcacaa tacggtgacc aatcttgctt tcattttttt   3660

ttctttttaa tttgaaccat gattttgcta gaaatagaag gcccagtggt ggaatattag   3720

agggaaggaa actgacaacg tgtgaaagtt agaggcaaat acataggtgt agcttggagt   3780

gctggtatct aatataccat tgtattcact aactaactca aaataaacac atttaatctt   3840

gacatctc                                                            3848


<210>  7768
<211>  906
<212>  PRT
<213>  Homosapiens

<400>  7768

Met Thr Ser Ala Thr Ser Pro Ile Ile Leu Lys Trp Asp Pro Lys Ser 
1               5                   10                  15      


Leu Glu Ile Arg Thr Leu Thr Val Glu Arg Leu Leu Glu Pro Leu Val 
            20                  25                  30          


Thr Gln Val Thr Thr Leu Val Asn Thr Ser Asn Lys Gly Pro Ser Gly 
        35                  40                  45              


Lys Lys Lys Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser Val 
    50                  55                  60                  


Glu Gln Ala Thr Gln Asn Phe Leu Glu Lys Gly Glu Gln Ile Ala Lys 
65                  70                  75                  80  


Glu Ser Gln Asp Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp Val 
                85                  90                  95      


Arg Lys Gln Gly Glu Thr Met Arg Ile Ala Ser Ser Glu Phe Ala Asp 
            100                 105                 110         


Asp Pro Cys Ser Ser Val Lys Arg Gly Thr Met Val Arg Ala Ala Arg 
        115                 120                 125             


Ala Leu Leu Ser Ala Val Thr Arg Leu Leu Ile Leu Ala Asp Met Ala 
    130                 135                 140                 


Asp Val Met Arg Leu Leu Ser His Leu Lys Ile Val Glu Glu Ala Leu 
145                 150                 155                 160 


Glu Ala Val Lys Asn Ala Thr Asn Glu Gln Asp Leu Ala Asn Arg Phe 
                165                 170                 175     


Lys Glu Phe Gly Lys Glu Met Val Lys Leu Asn Tyr Val Ala Ala Arg 
            180                 185                 190         


Arg Gln Gln Glu Leu Lys Asp Pro His Cys Arg Asp Glu Met Ala Ala 
        195                 200                 205             


Ala Arg Gly Ala Leu Lys Lys Asn Ala Thr Met Leu Tyr Thr Ala Ser 
    210                 215                 220                 


Gln Ala Phe Leu Arg His Pro Asp Val Ala Ala Thr Arg Ala Asn Arg 
225                 230                 235                 240 


Asp Tyr Val Phe Lys Gln Val Gln Glu Ala Ile Ala Gly Ile Ser Asn 
                245                 250                 255     


Ala Ala Gln Ala Thr Ser Pro Thr Asp Glu Ala Lys Gly His Thr Gly 
            260                 265                 270         


Ile Gly Glu Leu Ala Ala Ala Leu Asn Glu Phe Asp Asn Lys Ile Ile 
        275                 280                 285             


Leu Asp Pro Met Thr Phe Ser Glu Ala Arg Phe Arg Pro Ser Leu Glu 
    290                 295                 300                 


Glu Arg Leu Glu Ser Ser Ile Ile Ser Gly Ala Ala Leu Met Ala Asp 
305                 310                 315                 320 


Ser Ser Cys Thr Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu Cys 
                325                 330                 335     


Asn Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met Asn 
            340                 345                 350         


Asn Thr Gly Arg Lys Glu Lys Gly Asp Pro Leu Asn Ile Ala Ile Asp 
        355                 360                 365             


Lys Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala 
    370                 375                 380                 


Val Met Asp His Ile Ser Asp Ser Phe Leu Glu Thr Asn Val Pro Leu 
385                 390                 395                 400 


Leu Val Leu Ile Glu Ala Ala Lys Ser Gly Asn Glu Lys Glu Val Lys 
                405                 410                 415     


Glu Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Val Glu Val 
            420                 425                 430         


Ala Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu 
        435                 440                 445             


Val Arg Met Ala Ala Thr Gln Ile Asp Ser Leu Cys Pro Gln Val Ile 
    450                 455                 460                 


Asn Ala Ala Leu Thr Leu Ala Ala Arg Pro Gln Ser Lys Val Ala Gln 
465                 470                 475                 480 


Asp Asn Met Asp Val Phe Lys Asp Gln Trp Glu Lys Gln Val Arg Val 
                485                 490                 495     


Leu Thr Glu Ala Val Asp Asp Ile Thr Ser Val Asp Asp Phe Leu Ser 
            500                 505                 510         


Val Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile Ala 
        515                 520                 525             


Leu Gln Glu Gly Asp Val Asp Thr Leu Asp Arg Thr Ala Gly Ala Ile 
    530                 535                 540                 


Arg Gly Arg Ala Ala Arg Val Ile His Ile Ile Asn Ala Glu Met Glu 
545                 550                 555                 560 


Asn Tyr Glu Ala Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr Lys 
                565                 570                 575     


Leu Leu Ser Glu Thr Val Met Pro Arg Phe Ala Glu Gln Val Glu Val 
            580                 585                 590         


Ala Ile Glu Ala Leu Ser Ala Asn Val Pro Gln Pro Phe Glu Glu Asn 
        595                 600                 605             


Glu Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Val Arg Asp Ile 
    610                 615                 620                 


Arg Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Glu Asp Asp 
625                 630                 635                 640 


Ser Asp Phe Glu Gln Glu Asp Tyr Asp Val Arg Ser Arg Thr Ser Val 
                645                 650                 655     


Gln Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile 
            660                 665                 670         


Met Ala Gln Leu Pro Gln Glu Glu Lys Ala Lys Ile Ala Glu Gln Val 
        675                 680                 685             


Glu Ile Phe His Gln Glu Lys Ser Lys Leu Asp Ala Glu Val Ala Lys 
    690                 695                 700                 


Trp Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys 
705                 710                 715                 720 


Met Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu 
                725                 730                 735     


Lys Asn Thr Ser Asp Val Ile Asn Ala Ala Lys Lys Ile Ala Glu Ala 
            740                 745                 750         


Gly Ser Arg Met Asp Lys Leu Ala Arg Ala Val Ala Asp Gln Cys Pro 
        755                 760                 765             


Asp Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala 
    770                 775                 780                 


Leu Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val 
785                 790                 795                 800 


Gln Asn Leu Gly Gly Glu Leu Ile Val Ser Gly Leu Asp Ser Ala Thr 
                805                 810                 815     


Ser Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Leu Thr 
            820                 825                 830         


Val Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Val Tyr Gly 
        835                 840                 845             


Thr Ala Ala Val Asn Ser Pro Val Val Ser Trp Lys Met Lys Ala Pro 
    850                 855                 860                 


Glu Lys Lys Pro Leu Val Lys Arg Glu Lys Pro Glu Glu Phe Gln Thr 
865                 870                 875                 880 


Arg Val Arg Arg Gly Ser Gln Lys Lys His Ile Ser Pro Val Gln Ala 
                885                 890                 895     


Leu Ser Glu Phe Lys Ala Met Asp Ser Phe 
            900                 905     


<210>  7769
<211>  3987
<212>  DNA
<213>  Homosapiens

<400>  7769
gcttcgcttc cagccccgag tgaggcggag acccaggcgg gcgggcagag caggcggcac     60

cgcacctcgg ccagaggcgg ctgcagcagc tgctgccctt gtccctgccg ccgcctctcc    120

agtcccttct gtgattacca ctccagctgc tgggaacggg cgagaaagag gaggaggcga    180

gaaactccca ccgacccaca gagggagcat gacttcggca acttcaccta tcattctgaa    240

atgggacccc aaaagtttgg aaatccggac gctaacagtg gaaaggctgt tggagccact    300

tgttacacag gtgactacac ttgtcaacac aagcaacaaa ggcccatctg gtaaaaagaa    360

agggaggtca aagaaagccc atgtactagc tgcctctgta gagcaagcca ctcagaattt    420

cctggaaaag ggtgaacaga tcgctaagga gagtcaagat ctcaaagaag agttggtggc    480

tgctgtagag gatgtgcgca aacaaggtga gacgatgcgg atcgcctcct ccgagtttgc    540

agatgaccct tgctcgtcgg taaagcgcgg caccatggta cgggcggcaa gggctttgct    600

ctccgcggtg acacgcttac tcatcctggc ggacatggca gatgtcatga gacttttatc    660

ccatctgaaa attgtggaag aggccctgga agctgtcaaa aatgctacaa atgagcaaga    720

ccttgcaaac cgttttaaag agtttgggaa agagatggtg aaacttaact atgtagcagc    780

aagaagacaa caggagctga aggatcctca ctgtcgggat gagatggcag ccgcccgagg    840

ggctctgaag aagaatgcca caatgctgta cacggcctct caagcatttc tccgccaccc    900

agatgtcgcc gctacgagag ccaaccgaga ttatgtgttc aaacaagtcc aggaggccat    960

cgccggcatc tccaatgctg ctcaagctac ctcgcccact gacgaagcca agggccacac   1020

gggcatcggc gagctggctg cggctcttaa tgagtttgac aataagatta tcctggaccc   1080

catgacgttc agcgaggcca ggttccggcc gtccctggag gagaggctgg agagcagcat   1140

catcagcggc gcagcgctga tggccgactc ctcctgcacg cgagacgacc ggcgcgagag   1200

gatcgtggcg gagtgcaacg ccgtgcggca ggcgctccag gacctgctca gcgagtacat   1260

gaataatact ggaaggaaag aaaaaggaga tcctctcaac attgcgattg ataagatgac   1320

taagaaaaca agagatctaa ggagacagct tcggaaagca gtgatggatc acatatctga   1380

ctctttcctg gaaaccaatg ttcctttgct agttctcatt gaggctgcaa agagcggaaa   1440

tgaaaaggaa gtgaaagaat atgcccaagt tttccgtgag catgccaaca aactggtaga   1500

ggttgccaat ttggcctgtt ccatctccaa caatgaagaa ggggtgaaat tagttcggat   1560

ggcagccacc cagattgaca gcctgtgtcc ccaggtcatc aatgccgctc tgacactggc   1620

tgcccggcca cagagcaaag ttgctcagga taacatggac gtcttcaaag accagtggga   1680

gaagcaggtc cgagtgttga cagaggccgt ggatgacatc acctcagtgg atgacttcct   1740

ctctgtctca gaaaatcaca tcttggagga tgtgaacaag tgtgtgatag ccctccaaga   1800

gggcgatgtg gacactctgg accggactgc aggggccatc aggggccggg cagctcgagt   1860

catacacatc atcaatgctg agatggagaa ctatgaagct ggggtttata ctgagaaggt   1920

gttggaagct acaaaattgc tttctgaaac agtgatgcca cgcttcgctg aacaagtaga   1980

ggttgccatt gaagccctga gtgccaacgt tcctcaaccg tttgaggaga atgagttcat   2040

cgatgcctct cgcctggtgt atgatggcgt tcgggacatc agaaaggctg tgctgatgat   2100

caggacccca gaagaactag aggatgattc tgactttgag caggaagatt atgatgtgcg   2160

tagcaggaca agtgttcaga ctgaggatga ccagctcatt gcagggcaga gcgcacgggc   2220

catcatggcg caactaccgc aggaggagaa ggcaaaaata gctgagcagg tggagatatt   2280

ccatcaagag aaaagcaagc tggatgcaga agtggccaaa tgggacgaca gcggcaatga   2340

tatcattgta ctggccaagc agatgtgtat gatcatgatg gaaatgacag acttcacaag   2400

aggcaaaggc ccattgaaaa atacatctga tgtcattaat gctgccaaga aaattgccga   2460

agcaggttct cgaatggaca aattagctcg tgctgtggct gatcagtgtc ctgattcagc   2520

atgtaagcag gatttattag cctaccttca acgaattgcc ttgtattgcc atcagcttaa   2580

tatctgcagc aaggtgaagg cagaagtgca gaatctggga ggagagctca ttgtgtcagg   2640

gacaggagtt cagagcactt tcactacctt ttatgaggta gattgtgatg tcatagatgg   2700

gggcagggct agtcaacttt ctacccacct cccaacctgt gctgagggag ctccgatcgg   2760

gagtggaagc agtgattcct ccatgctgga cagtgccaca tcgcttatcc aggcagctaa   2820

aaacctgatg aatgctgttg tcctcacggt gaaagcatcc tatgtggcct caaccaaata   2880

ccagaaggtc tatgggacag cagctgtcaa ctcacctgtt gtgtcttgga agatgaaggc   2940

tccagagaag aagccccttg tgaagagaga aaagcctgaa gaattccaga cacgagttcg   3000

acgaggttct cagaagaaac acatttcgcc tgtacaggct ttaagtgaat tcaaagcaat   3060

ggattccttc taggacgata ggttttaaca agaaagcttt ttctttcttt tctttctttc   3120

tttttctttt taattccatt tttgtatgca tacctgccag ctcgtatgcc tctggcatgg   3180

ggaaattaag ggaacagtgt ctgtttgcat gtaagatgag atgagatcaa tactactgat   3240

ccatctgtag cctgggaagg agacaggaca ttcctgtact aaggtggcac agagctgtcc   3300

tttgcaacat tctcataaaa ttgggcacag agttcgcatt ggcgcaatat ttatgggagt   3360

gggagggatg gggaaaataa acttaactct acaaaagcaa actctaatgc atgcaagaat   3420

cattaggttg gcaggtatat gcataagtga aaaatctgga agtgtaatgg tagaacataa   3480

aacttgtatt gcttctgttt cagtgcaaaa atgtactagc caatacgctt aagtgtgtgg   3540

cccatgaatt gaacaattta accttgaagt ctatatccgt gatattatgt cgatttttaa   3600

ctgaggggaa attaactagt ccagcctaaa atgcttcttt taatctgcat tctgtttcct   3660

cttctagttg tgccattact agtgatcatg tttttttccc ccctttaatg aaaacaataa   3720

acatctattt gagacaatta aaatccttct gggggcactg gaagcacaat acggtgacca   3780

atcttgcttt catttttttt tctttttaat ttgaaccatg attttgctag aaatagaagg   3840

cccagtggtg gaatattaga gggaaggaaa ctgacaacgt gtgaaagtta gaggcaaata   3900

cataggtgta gcttggagtg ctggtatcta atataccatt gtattcacta actaactcaa   3960

aataaacaca tttaatcttg acatctc                                       3987


<210>  7770
<211>  954
<212>  PRT
<213>  Homosapiens

<400>  7770

Met Thr Ser Ala Thr Ser Pro Ile Ile Leu Lys Trp Asp Pro Lys Ser 
1               5                   10                  15      


Leu Glu Ile Arg Thr Leu Thr Val Glu Arg Leu Leu Glu Pro Leu Val 
            20                  25                  30          


Thr Gln Val Thr Thr Leu Val Asn Thr Ser Asn Lys Gly Pro Ser Gly 
        35                  40                  45              


Lys Lys Lys Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser Val 
    50                  55                  60                  


Glu Gln Ala Thr Gln Asn Phe Leu Glu Lys Gly Glu Gln Ile Ala Lys 
65                  70                  75                  80  


Glu Ser Gln Asp Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp Val 
                85                  90                  95      


Arg Lys Gln Gly Glu Thr Met Arg Ile Ala Ser Ser Glu Phe Ala Asp 
            100                 105                 110         


Asp Pro Cys Ser Ser Val Lys Arg Gly Thr Met Val Arg Ala Ala Arg 
        115                 120                 125             


Ala Leu Leu Ser Ala Val Thr Arg Leu Leu Ile Leu Ala Asp Met Ala 
    130                 135                 140                 


Asp Val Met Arg Leu Leu Ser His Leu Lys Ile Val Glu Glu Ala Leu 
145                 150                 155                 160 


Glu Ala Val Lys Asn Ala Thr Asn Glu Gln Asp Leu Ala Asn Arg Phe 
                165                 170                 175     


Lys Glu Phe Gly Lys Glu Met Val Lys Leu Asn Tyr Val Ala Ala Arg 
            180                 185                 190         


Arg Gln Gln Glu Leu Lys Asp Pro His Cys Arg Asp Glu Met Ala Ala 
        195                 200                 205             


Ala Arg Gly Ala Leu Lys Lys Asn Ala Thr Met Leu Tyr Thr Ala Ser 
    210                 215                 220                 


Gln Ala Phe Leu Arg His Pro Asp Val Ala Ala Thr Arg Ala Asn Arg 
225                 230                 235                 240 


Asp Tyr Val Phe Lys Gln Val Gln Glu Ala Ile Ala Gly Ile Ser Asn 
                245                 250                 255     


Ala Ala Gln Ala Thr Ser Pro Thr Asp Glu Ala Lys Gly His Thr Gly 
            260                 265                 270         


Ile Gly Glu Leu Ala Ala Ala Leu Asn Glu Phe Asp Asn Lys Ile Ile 
        275                 280                 285             


Leu Asp Pro Met Thr Phe Ser Glu Ala Arg Phe Arg Pro Ser Leu Glu 
    290                 295                 300                 


Glu Arg Leu Glu Ser Ser Ile Ile Ser Gly Ala Ala Leu Met Ala Asp 
305                 310                 315                 320 


Ser Ser Cys Thr Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu Cys 
                325                 330                 335     


Asn Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met Asn 
            340                 345                 350         


Asn Thr Gly Arg Lys Glu Lys Gly Asp Pro Leu Asn Ile Ala Ile Asp 
        355                 360                 365             


Lys Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala 
    370                 375                 380                 


Val Met Asp His Ile Ser Asp Ser Phe Leu Glu Thr Asn Val Pro Leu 
385                 390                 395                 400 


Leu Val Leu Ile Glu Ala Ala Lys Ser Gly Asn Glu Lys Glu Val Lys 
                405                 410                 415     


Glu Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Val Glu Val 
            420                 425                 430         


Ala Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu 
        435                 440                 445             


Val Arg Met Ala Ala Thr Gln Ile Asp Ser Leu Cys Pro Gln Val Ile 
    450                 455                 460                 


Asn Ala Ala Leu Thr Leu Ala Ala Arg Pro Gln Ser Lys Val Ala Gln 
465                 470                 475                 480 


Asp Asn Met Asp Val Phe Lys Asp Gln Trp Glu Lys Gln Val Arg Val 
                485                 490                 495     


Leu Thr Glu Ala Val Asp Asp Ile Thr Ser Val Asp Asp Phe Leu Ser 
            500                 505                 510         


Val Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile Ala 
        515                 520                 525             


Leu Gln Glu Gly Asp Val Asp Thr Leu Asp Arg Thr Ala Gly Ala Ile 
    530                 535                 540                 


Arg Gly Arg Ala Ala Arg Val Ile His Ile Ile Asn Ala Glu Met Glu 
545                 550                 555                 560 


Asn Tyr Glu Ala Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr Lys 
                565                 570                 575     


Leu Leu Ser Glu Thr Val Met Pro Arg Phe Ala Glu Gln Val Glu Val 
            580                 585                 590         


Ala Ile Glu Ala Leu Ser Ala Asn Val Pro Gln Pro Phe Glu Glu Asn 
        595                 600                 605             


Glu Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Val Arg Asp Ile 
    610                 615                 620                 


Arg Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Glu Asp Asp 
625                 630                 635                 640 


Ser Asp Phe Glu Gln Glu Asp Tyr Asp Val Arg Ser Arg Thr Ser Val 
                645                 650                 655     


Gln Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile 
            660                 665                 670         


Met Ala Gln Leu Pro Gln Glu Glu Lys Ala Lys Ile Ala Glu Gln Val 
        675                 680                 685             


Glu Ile Phe His Gln Glu Lys Ser Lys Leu Asp Ala Glu Val Ala Lys 
    690                 695                 700                 


Trp Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys 
705                 710                 715                 720 


Met Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu 
                725                 730                 735     


Lys Asn Thr Ser Asp Val Ile Asn Ala Ala Lys Lys Ile Ala Glu Ala 
            740                 745                 750         


Gly Ser Arg Met Asp Lys Leu Ala Arg Ala Val Ala Asp Gln Cys Pro 
        755                 760                 765             


Asp Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala 
    770                 775                 780                 


Leu Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val 
785                 790                 795                 800 


Gln Asn Leu Gly Gly Glu Leu Ile Val Ser Gly Thr Gly Val Gln Ser 
                805                 810                 815     


Thr Phe Thr Thr Phe Tyr Glu Val Asp Cys Asp Val Ile Asp Gly Gly 
            820                 825                 830         


Arg Ala Ser Gln Leu Ser Thr His Leu Pro Thr Cys Ala Glu Gly Ala 
        835                 840                 845             


Pro Ile Gly Ser Gly Ser Ser Asp Ser Ser Met Leu Asp Ser Ala Thr 
    850                 855                 860                 


Ser Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Leu Thr 
865                 870                 875                 880 


Val Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Val Tyr Gly 
                885                 890                 895     


Thr Ala Ala Val Asn Ser Pro Val Val Ser Trp Lys Met Lys Ala Pro 
            900                 905                 910         


Glu Lys Lys Pro Leu Val Lys Arg Glu Lys Pro Glu Glu Phe Gln Thr 
        915                 920                 925             


Arg Val Arg Arg Gly Ser Gln Lys Lys His Ile Ser Pro Val Gln Ala 
    930                 935                 940                 


Leu Ser Glu Phe Lys Ala Met Asp Ser Phe 
945                 950                 


<210>  7771
<211>  4044
<212>  DNA
<213>  Homosapiens

<400>  7771
gcttcgcttc cagccccgag tgaggcggag acccaggcgg gcgggcagag caggcggcac     60

cgcacctcgg ccagaggcgg ctgcagcagc tgctgccctt gtccctgccg ccgcctctcc    120

agtcccttct gtgattacca ctccagctgc tgggaacggg cgagaaagag gaggaggcga    180

gaaactccca ccgacccaca gagggagcat gacttcggca acttcaccta tcattctgaa    240

atgggacccc aaaagtttgg aaatccggac gctaacagtg gaaaggctgt tggagccact    300

tgttacacag gtgactacac ttgtcaacac aagcaacaaa ggcccatctg gtaaaaagaa    360

agggaggtca aagaaagccc atgtactagc tgcctctgta gagcaagcca ctcagaattt    420

cctggaaaag ggtgaacaga tcgctaagga gagtcaagat ctcaaagaag agttggtggc    480

tgctgtagag gatgtgcgca aacaaggtga gacgatgcgg atcgcctcct ccgagtttgc    540

agatgaccct tgctcgtcgg taaagcgcgg caccatggta cgggcggcaa gggctttgct    600

ctccgcggtg acacgcttac tcatcctggc ggacatggca gatgtcatga gacttttatc    660

ccatctgaaa attgtggaag aggccctgga agctgtcaaa aatgctacaa atgagcaaga    720

ccttgcaaac cgttttaaag agtttgggaa agagatggtg aaacttaact atgtagcagc    780

aagaagacaa caggagctga aggatcctca ctgtcgggat gagatggcag ccgcccgagg    840

ggctctgaag aagaatgcca caatgctgta cacggcctct caagcatttc tccgccaccc    900

agatgtcgcc gctacgagag ccaaccgaga ttatgtgttc aaacaagtcc aggaggccat    960

cgccggcatc tccaatgctg ctcaagctac ctcgcccact gacgaagcca agggccacac   1020

gggcatcggc gagctggctg cggctcttaa tgagtttgac aataagatta tcctggaccc   1080

catgacgttc agcgaggcca ggttccggcc gtccctggag gagaggctgg agagcagcat   1140

catcagcggc gcagcgctga tggccgactc ctcctgcacg cgagacgacc ggcgcgagag   1200

gatcgtggcg gagtgcaacg ccgtgcggca ggcgctccag gacctgctca gcgagtacat   1260

gaataatact ggaaggaaag aaaaaggaga tcctctcaac attgcgattg ataagatgac   1320

taagaaaaca agagatctaa ggagacagct tcggaaagca gtgatggatc acatatctga   1380

ctctttcctg gaaaccaatg ttcctttgct agttctcatt gaggctgcaa agagcggaaa   1440

tgaaaaggaa gtgaaagaat atgcccaagt tttccgtgag catgccaaca aactggtaga   1500

ggttgccaat ttggcctgtt ccatctccaa caatgaagaa ggggtgaaat tagttcggat   1560

ggcagccacc cagattgaca gcctgtgtcc ccaggtcatc aatgccgctc tgacactggc   1620

tgcccggcca cagagcaaag ttgctcagga taacatggac gtcttcaaag accagtggga   1680

gaagcaggtc cgagtgttga cagaggccgt ggatgacatc acctcagtgg atgacttcct   1740

ctctgtctca gaaaatcaca tcttggagga tgtgaacaag tgtgtgatag ccctccaaga   1800

gggcgatgtg gacactctgg accggactgc aggggccatc aggggccggg cagctcgagt   1860

catacacatc atcaatgctg agatggagaa ctatgaagct ggggtttata ctgagaaggt   1920

gttggaagct acaaaattgc tttctgaaac agtgatgcca cgcttcgctg aacaagtaga   1980

ggttgccatt gaagccctga gtgccaacgt tcctcaaccg tttgaggaga atgagttcat   2040

cgatgcctct cgcctggtgt atgatggcgt tcgggacatc agaaaggctg tgctgatgat   2100

caggacccca gaagaactag aggatgattc tgactttgag caggaagatt atgatgtgcg   2160

tagcaggaca agtgttcaga ctgaggatga ccagctcatt gcagggcaga gcgcacgggc   2220

catcatggcg caactaccgc aggaggagaa ggcaaaaata gctgagcagg tggagatatt   2280

ccatcaagag aaaagcaagc tggatgcaga agtggccaaa tgggacgaca gcggcaatga   2340

tatcattgta ctggccaagc agatgtgtat gatcatgatg gaaatgacag acttcacaag   2400

aggcaaaggc ccattgaaaa atacatctga tgtcattaat gctgccaaga aaattgccga   2460

agcaggttct cgaatggaca aattagctcg tgctgtggct gatcagtgtc ctgattcagc   2520

atgtaagcag gatttattag cctaccttca acgaattgcc ttgtattgcc atcagcttaa   2580

tatctgcagc aaggtgaagg cagaagtgca gaatctggga ggagagctca ttgtgtcagg   2640

gacaggagtt cagagcactt tcactacctt ttatgaggta gattgtgatg tcatagatgg   2700

gggcagggct agtcaacttt ctacccacct cccaacctgt gctgagggag ctccgatcgg   2760

gagtggaagc agtgattcct ccatgctgga cagtgccaca tcgcttatcc aggcagctaa   2820

aaacctgatg aatgctgttg tcctcacggt gaaagcatcc tatgtggcct caaccaaata   2880

ccagaaggtc tatgggacag cagctgtcaa ctcacctgtt gtgtcttgga agatgaaggc   2940

tccagagaag aagccccttg tgaagagaga aaagcctgaa gaattccaga cacgagttcg   3000

acgaggttct cagaagaaac acatttcgcc tgtacaggct ttaagtgaat tcaaagcaat   3060

ggattccttc taggacgata ggttttaaca agaaagcttt ttctttcttt tctttctttc   3120

tttttctttt taattccatt tttgtatgca tacctgccag ctcgtatgcc tctggcatgg   3180

ggaaattaag ggaacagtgt ctgtttgcat gtaagatgag atgagatcaa tactactgat   3240

ccatctgtag cctgggaagg agacaggaca ttcctgtact aaggtggcac agagctgtcc   3300

tttgcaacat tctcataaaa ttgggcacag agttcgcatt ggcgcaatat ttatgggagt   3360

gggagggatg gggaaaataa acttaactct acaaaagcaa actctaatgc atgcaagaat   3420

cattaggttg gcaggtatat gcataagtga aaaatctgga agtgtaatgg tagaacataa   3480

aacttgtatt gcttctgttt cagtgcaaaa atgtactagc caatacgctt aagtgtgtgg   3540

cccatgaatt gaacaattta accttgaagt ctatatccgt gatattatgt cgatttttaa   3600

ctgaggggaa attaactagt ccagcctaaa atgcttcttt taatctgcat tctgtttcct   3660

cttctagttg tgccattact agtgatcatg tttttttccc ccctttaatg aaaacaataa   3720

acatctattt gagacaatta aaatccttct gggggcactg gaagcacaat acggtgacca   3780

atcttgcttt catttttttt tctttttaat ttgaaccatg attttgctag aaatagaagg   3840

cccagtggtg gaatattaga gggaaggaaa ctgacaacgt gtgaaagtta gaggcaaata   3900

cataggtgta gcttggagtg ctggtatcta atataccatt gtattcacta actaactcaa   3960

aataaacaca tttaatcttg acatctcaag tatgttttct tttttaattt tttaagtatg   4020

tacttaataa agattagagc atca                                          4044


<210>  7772
<211>  954
<212>  PRT
<213>  Homosapiens

<400>  7772

Met Thr Ser Ala Thr Ser Pro Ile Ile Leu Lys Trp Asp Pro Lys Ser 
1               5                   10                  15      


Leu Glu Ile Arg Thr Leu Thr Val Glu Arg Leu Leu Glu Pro Leu Val 
            20                  25                  30          


Thr Gln Val Thr Thr Leu Val Asn Thr Ser Asn Lys Gly Pro Ser Gly 
        35                  40                  45              


Lys Lys Lys Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser Val 
    50                  55                  60                  


Glu Gln Ala Thr Gln Asn Phe Leu Glu Lys Gly Glu Gln Ile Ala Lys 
65                  70                  75                  80  


Glu Ser Gln Asp Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp Val 
                85                  90                  95      


Arg Lys Gln Gly Glu Thr Met Arg Ile Ala Ser Ser Glu Phe Ala Asp 
            100                 105                 110         


Asp Pro Cys Ser Ser Val Lys Arg Gly Thr Met Val Arg Ala Ala Arg 
        115                 120                 125             


Ala Leu Leu Ser Ala Val Thr Arg Leu Leu Ile Leu Ala Asp Met Ala 
    130                 135                 140                 


Asp Val Met Arg Leu Leu Ser His Leu Lys Ile Val Glu Glu Ala Leu 
145                 150                 155                 160 


Glu Ala Val Lys Asn Ala Thr Asn Glu Gln Asp Leu Ala Asn Arg Phe 
                165                 170                 175     


Lys Glu Phe Gly Lys Glu Met Val Lys Leu Asn Tyr Val Ala Ala Arg 
            180                 185                 190         


Arg Gln Gln Glu Leu Lys Asp Pro His Cys Arg Asp Glu Met Ala Ala 
        195                 200                 205             


Ala Arg Gly Ala Leu Lys Lys Asn Ala Thr Met Leu Tyr Thr Ala Ser 
    210                 215                 220                 


Gln Ala Phe Leu Arg His Pro Asp Val Ala Ala Thr Arg Ala Asn Arg 
225                 230                 235                 240 


Asp Tyr Val Phe Lys Gln Val Gln Glu Ala Ile Ala Gly Ile Ser Asn 
                245                 250                 255     


Ala Ala Gln Ala Thr Ser Pro Thr Asp Glu Ala Lys Gly His Thr Gly 
            260                 265                 270         


Ile Gly Glu Leu Ala Ala Ala Leu Asn Glu Phe Asp Asn Lys Ile Ile 
        275                 280                 285             


Leu Asp Pro Met Thr Phe Ser Glu Ala Arg Phe Arg Pro Ser Leu Glu 
    290                 295                 300                 


Glu Arg Leu Glu Ser Ser Ile Ile Ser Gly Ala Ala Leu Met Ala Asp 
305                 310                 315                 320 


Ser Ser Cys Thr Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu Cys 
                325                 330                 335     


Asn Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met Asn 
            340                 345                 350         


Asn Thr Gly Arg Lys Glu Lys Gly Asp Pro Leu Asn Ile Ala Ile Asp 
        355                 360                 365             


Lys Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala 
    370                 375                 380                 


Val Met Asp His Ile Ser Asp Ser Phe Leu Glu Thr Asn Val Pro Leu 
385                 390                 395                 400 


Leu Val Leu Ile Glu Ala Ala Lys Ser Gly Asn Glu Lys Glu Val Lys 
                405                 410                 415     


Glu Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Val Glu Val 
            420                 425                 430         


Ala Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu 
        435                 440                 445             


Val Arg Met Ala Ala Thr Gln Ile Asp Ser Leu Cys Pro Gln Val Ile 
    450                 455                 460                 


Asn Ala Ala Leu Thr Leu Ala Ala Arg Pro Gln Ser Lys Val Ala Gln 
465                 470                 475                 480 


Asp Asn Met Asp Val Phe Lys Asp Gln Trp Glu Lys Gln Val Arg Val 
                485                 490                 495     


Leu Thr Glu Ala Val Asp Asp Ile Thr Ser Val Asp Asp Phe Leu Ser 
            500                 505                 510         


Val Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile Ala 
        515                 520                 525             


Leu Gln Glu Gly Asp Val Asp Thr Leu Asp Arg Thr Ala Gly Ala Ile 
    530                 535                 540                 


Arg Gly Arg Ala Ala Arg Val Ile His Ile Ile Asn Ala Glu Met Glu 
545                 550                 555                 560 


Asn Tyr Glu Ala Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr Lys 
                565                 570                 575     


Leu Leu Ser Glu Thr Val Met Pro Arg Phe Ala Glu Gln Val Glu Val 
            580                 585                 590         


Ala Ile Glu Ala Leu Ser Ala Asn Val Pro Gln Pro Phe Glu Glu Asn 
        595                 600                 605             


Glu Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Val Arg Asp Ile 
    610                 615                 620                 


Arg Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Glu Asp Asp 
625                 630                 635                 640 


Ser Asp Phe Glu Gln Glu Asp Tyr Asp Val Arg Ser Arg Thr Ser Val 
                645                 650                 655     


Gln Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile 
            660                 665                 670         


Met Ala Gln Leu Pro Gln Glu Glu Lys Ala Lys Ile Ala Glu Gln Val 
        675                 680                 685             


Glu Ile Phe His Gln Glu Lys Ser Lys Leu Asp Ala Glu Val Ala Lys 
    690                 695                 700                 


Trp Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys 
705                 710                 715                 720 


Met Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu 
                725                 730                 735     


Lys Asn Thr Ser Asp Val Ile Asn Ala Ala Lys Lys Ile Ala Glu Ala 
            740                 745                 750         


Gly Ser Arg Met Asp Lys Leu Ala Arg Ala Val Ala Asp Gln Cys Pro 
        755                 760                 765             


Asp Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala 
    770                 775                 780                 


Leu Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val 
785                 790                 795                 800 


Gln Asn Leu Gly Gly Glu Leu Ile Val Ser Gly Thr Gly Val Gln Ser 
                805                 810                 815     


Thr Phe Thr Thr Phe Tyr Glu Val Asp Cys Asp Val Ile Asp Gly Gly 
            820                 825                 830         


Arg Ala Ser Gln Leu Ser Thr His Leu Pro Thr Cys Ala Glu Gly Ala 
        835                 840                 845             


Pro Ile Gly Ser Gly Ser Ser Asp Ser Ser Met Leu Asp Ser Ala Thr 
    850                 855                 860                 


Ser Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Leu Thr 
865                 870                 875                 880 


Val Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Val Tyr Gly 
                885                 890                 895     


Thr Ala Ala Val Asn Ser Pro Val Val Ser Trp Lys Met Lys Ala Pro 
            900                 905                 910         


Glu Lys Lys Pro Leu Val Lys Arg Glu Lys Pro Glu Glu Phe Gln Thr 
        915                 920                 925             


Arg Val Arg Arg Gly Ser Gln Lys Lys His Ile Ser Pro Val Gln Ala 
    930                 935                 940                 


Leu Ser Glu Phe Lys Ala Met Asp Ser Phe 
945                 950                 


<210>  7773
<211>  550
<212>  DNA
<213>  Homosapiens

<400>  7773
ggagacccag gcgggcgggc agagcaggcg gcaccgcacc tcggccagag gcggctgcag     60

cagctgctgc ccttgtccct gccgccgcct ctccagtccc ttctgtgatt accactccag    120

ctgctgggaa cgggcgagaa agaggaggag gcgagaaact cccaccgacc cacagaggga    180

gcatgacttc ggcaacttca cctatcattc tgaaatggga ccccaaaagt ttggaaatcc    240

ggacgctaac agtggaaagg ctgttggagc cacttgttac acaggtgact acacttgtca    300

acacaagcaa caaaggccca tctggtaaaa agaaagggag gtcaaagaaa gcccatgtac    360

tagctgcctc tgtagagcaa gccactcaga atttcctgga aaagggtgaa cagatcgcta    420

aggagagtca agatctcaaa gaagagttgg tggctgctgt agaggatgtg cgcaaacaag    480

gtgagacgat gcggatcgcc tcctccgagt ttgcagatga cccttgctcg tcggtaaagc    540

gcggcaccat                                                           550


<210>  7774
<211>  121
<212>  PRT
<213>  Homosapiens

<400>  7774

Met Thr Ser Ala Thr Ser Pro Ile Ile Leu Lys Trp Asp Pro Lys Ser 
1               5                   10                  15      


Leu Glu Ile Arg Thr Leu Thr Val Glu Arg Leu Leu Glu Pro Leu Val 
            20                  25                  30          


Thr Gln Val Thr Thr Leu Val Asn Thr Ser Asn Lys Gly Pro Ser Gly 
        35                  40                  45              


Lys Lys Lys Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser Val 
    50                  55                  60                  


Glu Gln Ala Thr Gln Asn Phe Leu Glu Lys Gly Glu Gln Ile Ala Lys 
65                  70                  75                  80  


Glu Ser Gln Asp Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp Val 
                85                  90                  95      


Arg Lys Gln Gly Glu Thr Met Arg Ile Ala Ser Ser Glu Phe Ala Asp 
            100                 105                 110         


Asp Pro Cys Ser Ser Val Lys Arg Gly 
        115                 120     


<210>  7775
<211>  384
<212>  DNA
<213>  Homosapiens

<400>  7775
taagtggcat accacttatt atacaagagg atgtggttga aacagtctgc cccaggaaca     60

accaataaga aggtgactac acttgtcaac acaagcaaca aaggcccatc tggtaaaaag    120

aaagggaggt caaagaaagc ccatgtacta gctgcctctg tagagcaagc cactcagaat    180

ttcctggaaa agggtgaaca gatcgctaag gagagtcaag atctcaaaga agagttggtg    240

gctgctgtag aggatgtgcg caaacaaggt tggccgactc gtgtatgtga gacctgcttg    300

ggctccagct gcggttaaac atgtctgtgg gaccagtagc ctgactttcc aatcagagct    360

ttgttgctgt gactgctgct gtgg                                           384


<210>  7776
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  7776

Met Trp Leu Lys Gln Ser Ala Pro Gly Thr Thr Asn Lys Lys Val Thr 
1               5                   10                  15      


Thr Leu Val Asn Thr Ser Asn Lys Gly Pro Ser Gly Lys Lys Lys Gly 
            20                  25                  30          


Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser Val Glu Gln Ala Thr 
        35                  40                  45              


Gln Asn Phe Leu Glu Lys Gly Glu Gln Ile Ala Lys Glu Ser Gln Asp 
    50                  55                  60                  


Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp Val Arg Lys Gln Gly 
65                  70                  75                  80  


Trp Pro Thr Arg Val Cys Glu Thr Cys Leu Gly Ser Ser Cys Gly 
                85                  90                  95  


<210>  7777
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  7777
agcggctccg aggggggcgg gtccgggagg ctgtgcgtgt cttgtgagag ctcttgaacc     60

aagtcagcgc tggagtcggc taggcggctg gaaacggcgg ctgccgccgg tgactcaggg    120

aggcgggagg cgggggagga gctcttcctg caggcgtgga aaccatggtg ctcacgctcg    180

gagaaagttg gccggtattg gtggggagga ggtttctcag tctgtccgca gccgacggca    240

gcgatggcag ccacgacagc tgggacgtgg agcgcgtcgc cgagtggccc tggctctccg    300

ggaccattcg agctgtttcc cacaccgacg ttaccaagaa ggatctgaag gtgtgtgtgg    360

aatttgatgg ggaatcttgg aggaaaagaa gatggataga agtctacagc cttctaagga    420

gagcattttt agtagaacat aatttggttt tagctgaacg aaagtcacct gaaatttctg    480

aacgaattgt acagtggcct gcaataacgt acaaacctct gttggacaaa gctggtttgg    540

gatccataac ttctgttcgc tttctgggag atcaacaaag agtatttctt tctaaagacc    600

ttttgaagcc tatacaggat gtaaacagtc ttcgactttc tcttacggat aatcagattg    660

tcagtaaaga atttcaagct ttgattgtga agcatttaga tgaaagccat cttttaaaag    720

gtgacaaaaa cttagttggt tcagaagtaa aaatttatag cttggaccca tctactcagt    780

ggttttcagc aaccgttata aatggaaacc cagcatcaaa aactcttcaa gtcaactgtg    840

aggagattcc agcactgaaa attgttgatc cgtcactgat tcatgttgaa gttgtacacg    900

ataaccttgt gacatgtggt aattctgcaa gaattggagc tgtaaaacgc aagtcttctg    960

agaataatgg aaccctggtt tccaaacaag caaaatcttg ctctgaggcc tctcccagta   1020

tgtgtcctgt gcagtctgta cctacaacag tttttaagga gatactgctt ggctgtactg   1080

cggcaactcc acctagtaag gacccaagac agcaaagtac tccccaggct gccaactctc   1140

cacctaacct tggagcaaaa attcctcaag gatgtcataa acaaagttta ccagaggaaa   1200

tttcttcctg tctaaataca aagtctgaag ctctgagaac aaaaccagat gtctgcaaag   1260

cagggttgct ctcaaagtcc tctcagattg gaactggaga cttgaaaatt ctgactgagc   1320

caaaaggcag ctgtactcag cctaagacaa acactgatca ggaaaacaga ttggagtctg   1380

ttccacaagc attgactggc cttcctaagg agtgcttacc tacaaaggct tcttctaagg   1440

cagaattgga aattgccaat cctcctgaac tgcagaagca cctagaacat gcaccttccc   1500

catcggatgt ttcaaatgca ccagaagtga aagcaggtgt caatagtgat agccctaata   1560

actgttcagg aaaaaaggta gaaccttcag ctttagcttg ccgatcacag aatttaaagg   1620

aatcttcagt aaaagtagat aatgaaagct gttgttcaag aagcaacaat aaaatccaga   1680

atgccccatc caggaagtcg gttttgacag acccagctaa actcaaaaag ctgcaacaga   1740

gtggcgaggc cttcgtacag gatgattctt gtgtgaacat cgtggcacag ttgcctaaat   1800

gccgagagtg tcgcttggac agtctccgca aggataagga gcaacagaag gactcacctg   1860

tgttttgccg cttctttcac ttcaggaggt tacaattcaa caaacatggt gtgttgcggg   1920

tagaaggctt cttaacacca aacaagtatg acaatgaagc aattggcttg tggttacctt   1980

taaccaaaaa cgttgtgggg attgatttgg acacagcaaa gtacatcttg gccaacattg   2040

gagaccactt ctgtcaaatg gtgatttctg aaaaggaagc tatgtcaact attgagccac   2100

acagacaggt tgcttggaag cgagctgtca aaggtgttcg agaaatgtgt gatgtgtgcg   2160

acaccaccat cttcaacctg cactgggtgt gtcctcggtg tgggtttgga gtatgtgtgg   2220

actgctaccg gatgaagaga aagaattgcc aacagggtga gaaccgattt gattctcctc   2280

cagcccctct acacagttaa atcaagtgtt tttgttgatt tgtgtttggc gggtttcttg   2340

aagcatgtgg agacagagtc tgtaaagaac agttactaca aatcagttat ttgcaggtgc   2400

tgcttacaag actttctctt ggctaaaatg tgtgaagagt cagatacatg aaccagagaa   2460

cttaatgccc acacagatca ttcctggaaa agcactctat gatgttggag acattgttca   2520

ttctgtaaga gcgaaatggg gaataaaggc aaactgccct tgttcaaaca ggcaattcaa   2580

actcttttca aagccagcct caaaggaaga cctaaaacag gtatttactg cttatgttaa   2640

attcaacatc tcttgtaatt gtcatttgtc tgtttttcaa ataacccaag gatttctatc   2700

agtgcatttg aaaggaacct ggggatagct atcaagtgga aagagagaga gaaagaattc   2760

atacagttca tgtgacagtt cagagacccg ttctgacttt tcacattact ttcgtagact   2820

ctactgtggc ctcttgtagt aggttttaca tttttgtttc ttgaagaagc acaaagttct   2880

aaagtagtct acctaataag tagctgtcga atttgtaaag ggtttaaaaa aattttttgt   2940

gtattttgca gaattaaaat tattaagata agctttaaca tttttaaaat tactaaatat   3000

attttgcctg tgtttatgca gagttgaagg aaatgatgaa atgaaccttt agttgcccat   3060

cacacaatgt aaaaaatgtt aattttctca gtcctcatat gtctctcctt ggtggcatcc   3120

ctctcctccc caccatcaca tgtacgtctt gctgtccctt ctccccctcg ttccagtaat   3180

cagtatgccg cattgtgttt aataatcaga aatttacatt tctataaagc tgtggtgtca   3240

taaggcagga tgggagagca gaagacttgt aatatttgga gtcagaactg aatttgagtt   3300

cttttccttc cacgtgctag ttgtgttact ttggctgaag tgagctggtt tctatgtgct   3360

tcagcttcct catcagtaat atagaaataa gaagcaatat tgatgattgg gcatcacaga   3420

attacatcac atgtaaagag agggcctgga ccacaacagg ggtttgaata ttttttttcc   3480

tccttcttat gtatgtataa actcactctt gccagttttt aaaattattt tcttctacag   3540

cagtcatctt agatttaatt tatgggttct tttaagagct catcacattt ttaaagctaa   3600

gtcaaaatag cattttctct ttctctgcat cccatttcct tctgaaatca ccgctttacc   3660

tttcctgcct gcgtcattta ttcgttttta accatgtttt ctgtgcctat cctgaattct   3720

gggatgagtt cataggggag acaggcacaa actggtcatt ttaaaccagc atggtacata   3780

gagtaatagg gatatgtacc agcaggggct ggtgaaaggg tgcggggggt aataccttgc   3840

tgtgtttaag ttgctgacat ctctcctacc ttttagttat tctctactag tgcgggatta   3900

ctgcagctgt ggggataccc agggctaact attaggtggt tttgttctgg atatttatct   3960

tacttgttgg tcggctatta ggagagaaga aaagaaaagg aagctgtcat tcttcagctt   4020

atgtaaaatc gtcctttaat gcttaacaca gacttcttta gctggagaaa aaccgactct   4080

tggtgcagtg ctccagcaga atccctcagt gttggagcca gcagctgtgg gtggggaagc   4140

agcctccaag ccagccggca gcatgaagcc tgcctgtcca gccagcacat ctcctctaaa   4200

ctggctggcc gacctaacca gcgggaatgt caacaaggaa aacaaggaaa aacaaccaac   4260

aatgccaatt ttaaagaatg aaatcaaatg ccttccaccc ctcccacctt taagcaaatc   4320

cagcacagtc ctccatacgt ttaacagcac aattttgaca cccgtaagca acaacaattc   4380

tggtttcctc cggaatctct tgaattcttc tacaggaaag acagaaaatg gactcaagaa   4440

tacaccaaaa atccttgatg acatctttgc ctctttggtg caaaataaga cgacttctga   4500

tttatctaag aggcctcaag gactaaccat caagcccagc attctgggct ttgacactcc   4560

tcactattgg ctttgtgata atcgcttgct gtgcttgcaa gaccccaaca ataagagcaa   4620

ctggaatgtg tttagggagt gctggaaaca agggcaggta atgtaggcct cccatcctcc   4680

tgccctattc agaaccccct tctcagttcc tttagcagac ttctgacaac cccaccccag   4740

gctttccccc tccttcacct cctgttttat tctttattgt ttcaggtgaa tataatcagg   4800

tcaggatgtg gccatgggtc ttacttttta aagcagatgg tcctaagctg gacttttcca   4860

gtcaggtttt tgttgcttcc taccagtccc tgttgggttt ttgacgaggg catccaggct   4920

tggtgattcc tatggtaaac ttcagcagag gaagtgaggg tgtgactaca ggctgatggg   4980

atttgggaga tcagacaaaa tgtgctacaa aatcatgcac ccctcttacc tgaatgaaaa   5040

gcctgtgctg aaggcagttc taggtgggct agggccgcgt ggtgtcacat agtccccagg   5100

tgcctgcttc aaagggcagt gttgttggat cttaagtgcc ggttaatatc tttaggagaa   5160

tttctaggcc tgcttctgtg ctttcttgtt ttggttctgt tttctggatc tctggcttct   5220

ctgtttggcc agatagggtc tttgctaaag gaacactctg ctcttggaca agaatttggg   5280

agaattgcca aacagaaaga tgtgagtgtt taaccaaaaa taaatttcca aaatgttttt   5340

ctccatccag tgtactaata ggatttgctc atttaatcat atatagacaa gaaacaaaat   5400

gatgggctga atacagttta tcggcaggct ttctttcttg cttgtcaata ttttaatgtt   5460

agactatttc acataaaggt tagagcttct gggttgtctt agacggccaa aagatttggc   5520

accctcacac agccagtagt agtgaggggt gtcacaggcc atattcctgc ttggcaataa   5580

caggctcaag tacggtgggg tcagtcaccc tgtttcactg gtgactggtg tcactggaca   5640

ctccttccag cgcttgtctt cttcacagtc cgtcttgctg taagtaatga gatcttacta   5700

ggagaggtga tcctttctcc tagatgctta cccatgtagt ttgagagcaa gggtgtgtag   5760

cagatgaatg gtgaaggttg gaggtgcttt gggagctcag agaactaagc cgaaactgtc   5820

acatcaccat ctgagacgga gcaccagctc catggaaata taccaatagc agtgtgaaga   5880

gggactgcct tcgggagtgg ggacagagct ggcagagttc agactaaagt tttccttctc   5940

ttcatttagc cagtgatggt gtctggagtg catcataaat tgaactctga actttggaaa   6000

cctgaatcct tcaggaaaga gtttggtgag caggaagtag acctagttaa ttgtaggacc   6060

aatgaaatca tcacaggagc cacagtagga gacttctggg atggatttga agatgttcca   6120

aatcgtttga aaaatgaaaa agaaccaatg gtgttgaaac ttaaggactg gccaccagga   6180

gaagatttta gagatatgat gccttccagg tttgatgatc tgatggccaa cattccactg   6240

cccgagtaca caaggcgaga tggcaaactg aatttggcct ctaggctgcc aaactacttt   6300

gttcggccag atctgggccc caagatgtat aatgcttatg gattaatcac tcctgaagat   6360

cggaaatatg gaacaacaaa tcttcactta gatgtatctg atgcagctaa tgtcatggtc   6420

tatgtgggaa ttcccaaagg acagtgtgag caagaagaag aagtccttaa gaccatccaa   6480

gatggagatt ctgacgaact cacaataaag cgatttattg aaggaaaaga gaagccagga   6540

gcactgtggc acatatatgc tgcaaaggac acggagaaga taagggaatt tcttaaaaag   6600

gtgtgctgct tatggcatgt gtgaacagag gcataaggaa tagcaatatt atgttactac   6660

atgtggtgaa ctgactggct tggctagggg aattgtcaca acctgaaaag ttaaatctgt   6720

acctgtcaga ttgaataggc tgaaggtggt tgctaaggaa caaggattct aaatgattag   6780

ggttacactt ctaaaaaaag caggccttgt cttttatgtc tgtgttttgt gttagagtgc   6840

atttagagat ttttgttctc tgctttcaag ttagaagtta gttcatctga tcatctccca   6900

gcatatatct gtttttattg ccttgagaat ctgagcactt cagacgttca tgtatccttg   6960

gccctgagtg accatgttct gagtgagttg ctaagtttgg ttttgtccac tgtcatgtag   7020

caagtggtcc tacttgttac tagcaagggt tgcagggatt tggaagattc taggtttccc   7080

ctgtagttgg caggtttttt tttcagcaag ggctatgtgt ggaaattcta ggcaactaga   7140

aagatgagtc gtgttcagtt ttaaaattgt ttggcactga ggctgccggt tgcaactcag   7200

gtgtctttgg ctgatattct tcagtcattc atgagtcttg gatatgaaca ttcgtaacct   7260

gttagctggc cccaagtatg tctttaacaa gcatttgttt gaatcaaagt gtttctggct   7320

aaggatcatt tggctcttcc agaaaaccgg cttggtcacc atattgttct tttgatattg   7380

tcactctgag tctctgcttt accagttact ggatcaagga taaacaagtc taatctgcag   7440

ctgtctttgg gactgtttcg taagtcagat taagtaaagg caggtttcta ataactttaa   7500

aacaagttca tttataagga tactgagcct acttatgttt aaaaatctag actaaaatat   7560

tgtttaaata cagtatttac aaacttatgc agagcctgtc agtcatggtt tatgggaact   7620

gacatcacat tttcttcgtc attcttctgt tggttcattc agctgaagtc tttgatacta   7680

ctagtcgtct tctgccaatg ggggcactta agttgaagaa ggcctgacat ttatgaactg   7740

ccaacactgt ttagaggaaa aaaatggctt attgggcctt agcatgttac tgagttgcat   7800

aatattttga atgtattcta ggtatcagaa gagcaaggtc aagaaaaccc agcagaccac   7860

gatcctattc atgatcaaag ctggtattta gaccgatcat taagaaaacg tcttcatcaa   7920

gagtatggag ttcaaggctg ggctattgta cagtttcttg gggatgtggt gtttatcccg   7980

gcaggagctc cacatcaggt tcataactta tatagctgca tcaaagtggc tgaagatttt   8040

gtttctccag agcatgttaa acactgcttc tggcttactc aggaattccg atatctgtca   8100

cagactcata ccaatcacga agataaatta caggtgaaga atgttatcta ccatgcagtg   8160

aaagatgcag ttgctatgct gaaagccagt ga                                 8192


<210>  7778
<211>  711
<212>  PRT
<213>  Homosapiens

<400>  7778

Met Val Leu Thr Leu Gly Glu Ser Trp Pro Val Leu Val Gly Arg Arg 
1               5                   10                  15      


Phe Leu Ser Leu Ser Ala Ala Asp Gly Ser Asp Gly Ser His Asp Ser 
            20                  25                  30          


Trp Asp Val Glu Arg Val Ala Glu Trp Pro Trp Leu Ser Gly Thr Ile 
        35                  40                  45              


Arg Ala Val Ser His Thr Asp Val Thr Lys Lys Asp Leu Lys Val Cys 
    50                  55                  60                  


Val Glu Phe Asp Gly Glu Ser Trp Arg Lys Arg Arg Trp Ile Glu Val 
65                  70                  75                  80  


Tyr Ser Leu Leu Arg Arg Ala Phe Leu Val Glu His Asn Leu Val Leu 
                85                  90                  95      


Ala Glu Arg Lys Ser Pro Glu Ile Ser Glu Arg Ile Val Gln Trp Pro 
            100                 105                 110         


Ala Ile Thr Tyr Lys Pro Leu Leu Asp Lys Ala Gly Leu Gly Ser Ile 
        115                 120                 125             


Thr Ser Val Arg Phe Leu Gly Asp Gln Gln Arg Val Phe Leu Ser Lys 
    130                 135                 140                 


Asp Leu Leu Lys Pro Ile Gln Asp Val Asn Ser Leu Arg Leu Ser Leu 
145                 150                 155                 160 


Thr Asp Asn Gln Ile Val Ser Lys Glu Phe Gln Ala Leu Ile Val Lys 
                165                 170                 175     


His Leu Asp Glu Ser His Leu Leu Lys Gly Asp Lys Asn Leu Val Gly 
            180                 185                 190         


Ser Glu Val Lys Ile Tyr Ser Leu Asp Pro Ser Thr Gln Trp Phe Ser 
        195                 200                 205             


Ala Thr Val Ile Asn Gly Asn Pro Ala Ser Lys Thr Leu Gln Val Asn 
    210                 215                 220                 


Cys Glu Glu Ile Pro Ala Leu Lys Ile Val Asp Pro Ser Leu Ile His 
225                 230                 235                 240 


Val Glu Val Val His Asp Asn Leu Val Thr Cys Gly Asn Ser Ala Arg 
                245                 250                 255     


Ile Gly Ala Val Lys Arg Lys Ser Ser Glu Asn Asn Gly Thr Leu Val 
            260                 265                 270         


Ser Lys Gln Ala Lys Ser Cys Ser Glu Ala Ser Pro Ser Met Cys Pro 
        275                 280                 285             


Val Gln Ser Val Pro Thr Thr Val Phe Lys Glu Ile Leu Leu Gly Cys 
    290                 295                 300                 


Thr Ala Ala Thr Pro Pro Ser Lys Asp Pro Arg Gln Gln Ser Thr Pro 
305                 310                 315                 320 


Gln Ala Ala Asn Ser Pro Pro Asn Leu Gly Ala Lys Ile Pro Gln Gly 
                325                 330                 335     


Cys His Lys Gln Ser Leu Pro Glu Glu Ile Ser Ser Cys Leu Asn Thr 
            340                 345                 350         


Lys Ser Glu Ala Leu Arg Thr Lys Pro Asp Val Cys Lys Ala Gly Leu 
        355                 360                 365             


Leu Ser Lys Ser Ser Gln Ile Gly Thr Gly Asp Leu Lys Ile Leu Thr 
    370                 375                 380                 


Glu Pro Lys Gly Ser Cys Thr Gln Pro Lys Thr Asn Thr Asp Gln Glu 
385                 390                 395                 400 


Asn Arg Leu Glu Ser Val Pro Gln Ala Leu Thr Gly Leu Pro Lys Glu 
                405                 410                 415     


Cys Leu Pro Thr Lys Ala Ser Ser Lys Ala Glu Leu Glu Ile Ala Asn 
            420                 425                 430         


Pro Pro Glu Leu Gln Lys His Leu Glu His Ala Pro Ser Pro Ser Asp 
        435                 440                 445             


Val Ser Asn Ala Pro Glu Val Lys Ala Gly Val Asn Ser Asp Ser Pro 
    450                 455                 460                 


Asn Asn Cys Ser Gly Lys Lys Val Glu Pro Ser Ala Leu Ala Cys Arg 
465                 470                 475                 480 


Ser Gln Asn Leu Lys Glu Ser Ser Val Lys Val Asp Asn Glu Ser Cys 
                485                 490                 495     


Cys Ser Arg Ser Asn Asn Lys Ile Gln Asn Ala Pro Ser Arg Lys Ser 
            500                 505                 510         


Val Leu Thr Asp Pro Ala Lys Leu Lys Lys Leu Gln Gln Ser Gly Glu 
        515                 520                 525             


Ala Phe Val Gln Asp Asp Ser Cys Val Asn Ile Val Ala Gln Leu Pro 
    530                 535                 540                 


Lys Cys Arg Glu Cys Arg Leu Asp Ser Leu Arg Lys Asp Lys Glu Gln 
545                 550                 555                 560 


Gln Lys Asp Ser Pro Val Phe Cys Arg Phe Phe His Phe Arg Arg Leu 
                565                 570                 575     


Gln Phe Asn Lys His Gly Val Leu Arg Val Glu Gly Phe Leu Thr Pro 
            580                 585                 590         


Asn Lys Tyr Asp Asn Glu Ala Ile Gly Leu Trp Leu Pro Leu Thr Lys 
        595                 600                 605             


Asn Val Val Gly Ile Asp Leu Asp Thr Ala Lys Tyr Ile Leu Ala Asn 
    610                 615                 620                 


Ile Gly Asp His Phe Cys Gln Met Val Ile Ser Glu Lys Glu Ala Met 
625                 630                 635                 640 


Ser Thr Ile Glu Pro His Arg Gln Val Ala Trp Lys Arg Ala Val Lys 
                645                 650                 655     


Gly Val Arg Glu Met Cys Asp Val Cys Asp Thr Thr Ile Phe Asn Leu 
            660                 665                 670         


His Trp Val Cys Pro Arg Cys Gly Phe Gly Val Cys Val Asp Cys Tyr 
        675                 680                 685             


Arg Met Lys Arg Lys Asn Cys Gln Gln Gly Glu Asn Arg Phe Asp Ser 
    690                 695                 700                 


Pro Pro Ala Pro Leu His Ser 
705                 710     


<210>  7779
<211>  4744
<212>  DNA
<213>  Homosapiens

<400>  7779
agcggctccg aggggggcgg gtccgggagg ctgtgcgtgt cttgtgagag ctcttgaacc     60

aagtcagcgc tggagtcggc taggcggctg gaaacggcgg ctgccgccgg tgactcaggg    120

aggcgggagg cgggggagga gctcttcctg caggcgtgga aaccatggtg ctcacgctcg    180

gagaaagttg gccggtattg gtggggagga ggtttctcag tctgtccgca gccgacggca    240

gcgatggcag ccacgacagc tgggacgtgg agcgcgtcgc cgagtggccc tggctctccg    300

ggaccattcg agctgtttcc cacaccgacg ttaccaagaa ggatctgaag gtgtgtgtgg    360

aatttgatgg ggaatcttgg aggaaaagaa gatggataga agtctacagc cttctaagga    420

gagcattttt agtagaacat aatttggttt tagctgaacg aaagtcacct gaaatttctg    480

aacgaattgt acagtggcct gcaataacgt acaaacctct gttggacaaa gctggtttgg    540

gatccataac ttctgttcgc tttctgggag atcaacaaag agtatttctt tctaaagacc    600

ttttgaagcc tatacaggat gtaaacagtc ttcgactttc tcttacggat aatcagattg    660

tcagtaaaga atttcaagct ttgattgtga agcatttaga tgaaagccat cttttaaaag    720

gtgacaaaaa cttagttggt tcagaagtaa aaatttatag cttggaccca tctactcagt    780

ggttttcagc aaccgttata aatggaaacc cagcatcaaa aactcttcaa gtcaactgtg    840

aggagattcc agcactgaaa attgttgatc cgtcactgat tcatgttgaa gttgtacacg    900

ataaccttgt gacatgtggt aattctgcaa gaattggagc tgtaaaacgc aagtcttctg    960

agaataatgg aaccctggtt tccaaacaag caaaatcttg ctctgaggcc tctcccagta   1020

tgtgtcctgt gcagtctgta cctacaacag tttttaagga gatactgctt ggctgtactg   1080

cggcaactcc acctagtaag gacccaagac agcaaagtac tccccaggct gccaactctc   1140

cacctaacct tggagcaaaa attcctcaag gatgtcataa acaaagttta ccagaggaaa   1200

tttcttcctg tctaaataca aagtctgaag ctctgagaac aaaaccagat gtctgcaaag   1260

cagggttgct ctcaaagtcc tctcagattg gaactggaga cttgaaaatt ctgactgagc   1320

caaaaggcag ctgtactcag cctaagacaa acactgatca ggaaaacaga ttggagtctg   1380

ttccacaagc attgactggc cttcctaagg agtgcttacc tacaaaggct tcttctaagg   1440

cagaattgga aattgccaat cctcctgaac tgcagaagca cctagaacat gcaccttccc   1500

catcggatgt ttcaaatgca ccagaagtga aagcaggtgt caatagtgat agccctaata   1560

actgttcagg aaaaaaggta gaaccttcag ctttagcttg ccgatcacag aatttaaagg   1620

aatcttcagt aaaagtagat aatgaaagct gttgttcaag aagcaacaat aaaatccaga   1680

atgccccatc caggaagtcg gttttgacag acccagctaa actcaaaaag ctgcaacaga   1740

gtggcgaggc cttcgtacag gatgattctt gtgtgaacat cgtggcacag ttgcctaaat   1800

gccgagagtg tcgcttggac agtctccgca aggataagga gcaacagaag gactcacctg   1860

tgttttgccg cttctttcac ttcaggaggt tacaattcaa caaacatggt gtgttgcggg   1920

tagaaggctt cttaacacca aacaagtatg acaatgaagc aattggcttg tggttacctt   1980

taaccaaaaa cgttgtgggg attgatttgg acacagcaaa gtacatcttg gccaacattg   2040

gagaccactt ctgtcaaatg gtgatttctg aaaaggaagc tatgtcaact attgagccac   2100

acagacaggt tgcttggaag cgagctgtca aaggtgttcg agaaatgtgt gatgtgtgcg   2160

acaccaccat cttcaacctg cactgggtgt gtcctcggtg tgggtttgga gtatgtgtgg   2220

actgctaccg gatgaagaga aagaattgcc aacagggtgc tgcttacaag actttctctt   2280

ggctaaaatg tgtgaagagt cagatacatg aaccagagaa cttaatgccc acacagatca   2340

ttcctggaaa agcactctat gatgttggag acattgttca ttctgtaaga gcgaaatggg   2400

gaataaaggc aaactgccct tgttcaaaca ggcaattcaa actcttttca aagccagcct   2460

caaaggaaga cctaaaacag acttctttag ctggagaaaa accgactctt ggtgcagtgc   2520

tccagcagaa tccctcagtg ttggagccag cagctgtggg tggggaagca gcctccaagc   2580

cagccggcag catgaagcct gcctgtccag ccagcacatc tcctctaaac tggctggccg   2640

acctaaccag cgggaatgtc aacaaggaaa acaaggaaaa acaaccaaca atgccaattt   2700

taaagaatga aatcaaatgc cttccacccc tcccaccttt aagcaaatcc agcacagtcc   2760

tccatacgtt taacagcaca attttgacac ccgtaagcaa caacaattct ggtttcctcc   2820

ggaatctctt gaattcttct acaggaaaga cagaaaatgg actcaagaat acaccaaaaa   2880

tccttgatga catctttgcc tctttggtgc aaaataagac gacttctgat ttatctaaga   2940

ggcctcaagg actaaccatc aagcccagca ttctgggctt tgacactcct cactattggc   3000

tttgtgataa tcgcttgctg tgcttgcaag accccaacaa taagagcaac tggaatgtgt   3060

ttagggagtg ctggaaacaa gggcagccag tgatggtgtc tggagtgcat cataaattga   3120

actctgaact ttggaaacct gaatccttca ggaaagagtt tggtgagcag gaagtagacc   3180

tagttaattg taggaccaat gaaatcatca caggagccac agtaggagac ttctgggatg   3240

gatttgaaga tgttccaaat cgtttgaaaa atgaaaaaga accaatggtg ttgaaactta   3300

aggactggcc accaggagaa gattttagag atatgatgcc ttccaggttt gatgatctga   3360

tggccaacat tccactgccc gagtacacaa ggcgagatgg caaactgaat ttggcctcta   3420

ggctgccaaa ctactttgtt cggccagatc tgggccccaa gatgtataat gcttatggat   3480

taatcactcc tgaagatcgg aaatatggaa caacaaatct tcacttagat gtatctgatg   3540

cagctaatgt catggtctat gtgggaattc ccaaaggaca gtgtgagcaa gaagaagaag   3600

tccttaagac catccaagat ggagattctg acgaactcac aataaagcga tttattgaag   3660

gaaaagagaa gccaggagca ctgtggcaca tatatgctgc aaaggacacg gagaagataa   3720

gggaatttct taaaaaggta tcagaagagc aaggtcaaga aaacccagca gaccacgatc   3780

ctattcatga tcaaagctgg tatttagacc gatcattaag aaaacgtctt catcaagagt   3840

atggagttca aggctgggct attgtacagt ttcttgggga tgtggtgttt atcccggcag   3900

gagctccaca tcaggttcat aacttatata gctgcatcaa agtggctgaa gattttgttt   3960

ctccagagca tgttaaacac tgcttctggc ttactcagga attccgatat ctgtcacaga   4020

ctcataccaa tcacgaagat aaattacagg tgaagaatgt tatctaccat gcagtgaaag   4080

atgcagttgc tatgctgaaa gccagtgaat ccagttttgg caaaccttaa tctccctgca   4140

cattggaaat gaattacagg cagctgttca aactcttcag gcaggattcc tgtggacttt   4200

gagattcatg ttacctcatc ttctttttta aactgtaccc aacttgtgag ggtactctgt   4260

ctaatgtata tttctagtgt ttacagacag taaatgtgta tatgtagtaa ctatttacag   4320

aacatgcatc cttaaactgt gacttctcac ctagtgcaga acttttacca ggctgtaaaa   4380

gcaaaacctc gtatcagctc tggaacaata cctgcagtta ttcttcagct gtttggacaa   4440

cttagattgg gtttataact attaggaatc actgcacagt ttatttgggt tgtgttttgt   4500

gtctgagtcc cctccctcat cccttagggt ccagaagagc aatggaggaa gtgacagcta   4560

atgttgcagt tcttattgta tggcatagga ctggcattat atagcagaaa tcaactactg   4620

tacaatttct tggggttaac catctttagt taaatggaat tttaatttaa atgacgcttt   4680

gctaatttta agtgttaagc attttgcatt aaaatattca tataatattt tggctcagtt   4740

tatt                                                                4744


<210>  7780
<211>  1321
<212>  PRT
<213>  Homosapiens

<400>  7780

Met Val Leu Thr Leu Gly Glu Ser Trp Pro Val Leu Val Gly Arg Arg 
1               5                   10                  15      


Phe Leu Ser Leu Ser Ala Ala Asp Gly Ser Asp Gly Ser His Asp Ser 
            20                  25                  30          


Trp Asp Val Glu Arg Val Ala Glu Trp Pro Trp Leu Ser Gly Thr Ile 
        35                  40                  45              


Arg Ala Val Ser His Thr Asp Val Thr Lys Lys Asp Leu Lys Val Cys 
    50                  55                  60                  


Val Glu Phe Asp Gly Glu Ser Trp Arg Lys Arg Arg Trp Ile Glu Val 
65                  70                  75                  80  


Tyr Ser Leu Leu Arg Arg Ala Phe Leu Val Glu His Asn Leu Val Leu 
                85                  90                  95      


Ala Glu Arg Lys Ser Pro Glu Ile Ser Glu Arg Ile Val Gln Trp Pro 
            100                 105                 110         


Ala Ile Thr Tyr Lys Pro Leu Leu Asp Lys Ala Gly Leu Gly Ser Ile 
        115                 120                 125             


Thr Ser Val Arg Phe Leu Gly Asp Gln Gln Arg Val Phe Leu Ser Lys 
    130                 135                 140                 


Asp Leu Leu Lys Pro Ile Gln Asp Val Asn Ser Leu Arg Leu Ser Leu 
145                 150                 155                 160 


Thr Asp Asn Gln Ile Val Ser Lys Glu Phe Gln Ala Leu Ile Val Lys 
                165                 170                 175     


His Leu Asp Glu Ser His Leu Leu Lys Gly Asp Lys Asn Leu Val Gly 
            180                 185                 190         


Ser Glu Val Lys Ile Tyr Ser Leu Asp Pro Ser Thr Gln Trp Phe Ser 
        195                 200                 205             


Ala Thr Val Ile Asn Gly Asn Pro Ala Ser Lys Thr Leu Gln Val Asn 
    210                 215                 220                 


Cys Glu Glu Ile Pro Ala Leu Lys Ile Val Asp Pro Ser Leu Ile His 
225                 230                 235                 240 


Val Glu Val Val His Asp Asn Leu Val Thr Cys Gly Asn Ser Ala Arg 
                245                 250                 255     


Ile Gly Ala Val Lys Arg Lys Ser Ser Glu Asn Asn Gly Thr Leu Val 
            260                 265                 270         


Ser Lys Gln Ala Lys Ser Cys Ser Glu Ala Ser Pro Ser Met Cys Pro 
        275                 280                 285             


Val Gln Ser Val Pro Thr Thr Val Phe Lys Glu Ile Leu Leu Gly Cys 
    290                 295                 300                 


Thr Ala Ala Thr Pro Pro Ser Lys Asp Pro Arg Gln Gln Ser Thr Pro 
305                 310                 315                 320 


Gln Ala Ala Asn Ser Pro Pro Asn Leu Gly Ala Lys Ile Pro Gln Gly 
                325                 330                 335     


Cys His Lys Gln Ser Leu Pro Glu Glu Ile Ser Ser Cys Leu Asn Thr 
            340                 345                 350         


Lys Ser Glu Ala Leu Arg Thr Lys Pro Asp Val Cys Lys Ala Gly Leu 
        355                 360                 365             


Leu Ser Lys Ser Ser Gln Ile Gly Thr Gly Asp Leu Lys Ile Leu Thr 
    370                 375                 380                 


Glu Pro Lys Gly Ser Cys Thr Gln Pro Lys Thr Asn Thr Asp Gln Glu 
385                 390                 395                 400 


Asn Arg Leu Glu Ser Val Pro Gln Ala Leu Thr Gly Leu Pro Lys Glu 
                405                 410                 415     


Cys Leu Pro Thr Lys Ala Ser Ser Lys Ala Glu Leu Glu Ile Ala Asn 
            420                 425                 430         


Pro Pro Glu Leu Gln Lys His Leu Glu His Ala Pro Ser Pro Ser Asp 
        435                 440                 445             


Val Ser Asn Ala Pro Glu Val Lys Ala Gly Val Asn Ser Asp Ser Pro 
    450                 455                 460                 


Asn Asn Cys Ser Gly Lys Lys Val Glu Pro Ser Ala Leu Ala Cys Arg 
465                 470                 475                 480 


Ser Gln Asn Leu Lys Glu Ser Ser Val Lys Val Asp Asn Glu Ser Cys 
                485                 490                 495     


Cys Ser Arg Ser Asn Asn Lys Ile Gln Asn Ala Pro Ser Arg Lys Ser 
            500                 505                 510         


Val Leu Thr Asp Pro Ala Lys Leu Lys Lys Leu Gln Gln Ser Gly Glu 
        515                 520                 525             


Ala Phe Val Gln Asp Asp Ser Cys Val Asn Ile Val Ala Gln Leu Pro 
    530                 535                 540                 


Lys Cys Arg Glu Cys Arg Leu Asp Ser Leu Arg Lys Asp Lys Glu Gln 
545                 550                 555                 560 


Gln Lys Asp Ser Pro Val Phe Cys Arg Phe Phe His Phe Arg Arg Leu 
                565                 570                 575     


Gln Phe Asn Lys His Gly Val Leu Arg Val Glu Gly Phe Leu Thr Pro 
            580                 585                 590         


Asn Lys Tyr Asp Asn Glu Ala Ile Gly Leu Trp Leu Pro Leu Thr Lys 
        595                 600                 605             


Asn Val Val Gly Ile Asp Leu Asp Thr Ala Lys Tyr Ile Leu Ala Asn 
    610                 615                 620                 


Ile Gly Asp His Phe Cys Gln Met Val Ile Ser Glu Lys Glu Ala Met 
625                 630                 635                 640 


Ser Thr Ile Glu Pro His Arg Gln Val Ala Trp Lys Arg Ala Val Lys 
                645                 650                 655     


Gly Val Arg Glu Met Cys Asp Val Cys Asp Thr Thr Ile Phe Asn Leu 
            660                 665                 670         


His Trp Val Cys Pro Arg Cys Gly Phe Gly Val Cys Val Asp Cys Tyr 
        675                 680                 685             


Arg Met Lys Arg Lys Asn Cys Gln Gln Gly Ala Ala Tyr Lys Thr Phe 
    690                 695                 700                 


Ser Trp Leu Lys Cys Val Lys Ser Gln Ile His Glu Pro Glu Asn Leu 
705                 710                 715                 720 


Met Pro Thr Gln Ile Ile Pro Gly Lys Ala Leu Tyr Asp Val Gly Asp 
                725                 730                 735     


Ile Val His Ser Val Arg Ala Lys Trp Gly Ile Lys Ala Asn Cys Pro 
            740                 745                 750         


Cys Ser Asn Arg Gln Phe Lys Leu Phe Ser Lys Pro Ala Ser Lys Glu 
        755                 760                 765             


Asp Leu Lys Gln Thr Ser Leu Ala Gly Glu Lys Pro Thr Leu Gly Ala 
    770                 775                 780                 


Val Leu Gln Gln Asn Pro Ser Val Leu Glu Pro Ala Ala Val Gly Gly 
785                 790                 795                 800 


Glu Ala Ala Ser Lys Pro Ala Gly Ser Met Lys Pro Ala Cys Pro Ala 
                805                 810                 815     


Ser Thr Ser Pro Leu Asn Trp Leu Ala Asp Leu Thr Ser Gly Asn Val 
            820                 825                 830         


Asn Lys Glu Asn Lys Glu Lys Gln Pro Thr Met Pro Ile Leu Lys Asn 
        835                 840                 845             


Glu Ile Lys Cys Leu Pro Pro Leu Pro Pro Leu Ser Lys Ser Ser Thr 
    850                 855                 860                 


Val Leu His Thr Phe Asn Ser Thr Ile Leu Thr Pro Val Ser Asn Asn 
865                 870                 875                 880 


Asn Ser Gly Phe Leu Arg Asn Leu Leu Asn Ser Ser Thr Gly Lys Thr 
                885                 890                 895     


Glu Asn Gly Leu Lys Asn Thr Pro Lys Ile Leu Asp Asp Ile Phe Ala 
            900                 905                 910         


Ser Leu Val Gln Asn Lys Thr Thr Ser Asp Leu Ser Lys Arg Pro Gln 
        915                 920                 925             


Gly Leu Thr Ile Lys Pro Ser Ile Leu Gly Phe Asp Thr Pro His Tyr 
    930                 935                 940                 


Trp Leu Cys Asp Asn Arg Leu Leu Cys Leu Gln Asp Pro Asn Asn Lys 
945                 950                 955                 960 


Ser Asn Trp Asn Val Phe Arg Glu Cys Trp Lys Gln Gly Gln Pro Val 
                965                 970                 975     


Met Val Ser Gly Val His His Lys Leu Asn Ser Glu Leu Trp Lys Pro 
            980                 985                 990         


Glu Ser Phe Arg Lys Glu Phe Gly  Glu Gln Glu Val Asp  Leu Val Asn 
        995                 1000                 1005             


Cys Arg  Thr Asn Glu Ile Ile  Thr Gly Ala Thr Val  Gly Asp Phe 
    1010                 1015                 1020             


Trp Asp  Gly Phe Glu Asp Val  Pro Asn Arg Leu Lys  Asn Glu Lys 
    1025                 1030                 1035             


Glu Pro  Met Val Leu Lys Leu  Lys Asp Trp Pro Pro  Gly Glu Asp 
    1040                 1045                 1050             


Phe Arg  Asp Met Met Pro Ser  Arg Phe Asp Asp Leu  Met Ala Asn 
    1055                 1060                 1065             


Ile Pro  Leu Pro Glu Tyr Thr  Arg Arg Asp Gly Lys  Leu Asn Leu 
    1070                 1075                 1080             


Ala Ser  Arg Leu Pro Asn Tyr  Phe Val Arg Pro Asp  Leu Gly Pro 
    1085                 1090                 1095             


Lys Met  Tyr Asn Ala Tyr Gly  Leu Ile Thr Pro Glu  Asp Arg Lys 
    1100                 1105                 1110             


Tyr Gly  Thr Thr Asn Leu His  Leu Asp Val Ser Asp  Ala Ala Asn 
    1115                 1120                 1125             


Val Met  Val Tyr Val Gly Ile  Pro Lys Gly Gln Cys  Glu Gln Glu 
    1130                 1135                 1140             


Glu Glu  Val Leu Lys Thr Ile  Gln Asp Gly Asp Ser  Asp Glu Leu 
    1145                 1150                 1155             


Thr Ile  Lys Arg Phe Ile Glu  Gly Lys Glu Lys Pro  Gly Ala Leu 
    1160                 1165                 1170             


Trp His  Ile Tyr Ala Ala Lys  Asp Thr Glu Lys Ile  Arg Glu Phe 
    1175                 1180                 1185             


Leu Lys  Lys Val Ser Glu Glu  Gln Gly Gln Glu Asn  Pro Ala Asp 
    1190                 1195                 1200             


His Asp  Pro Ile His Asp Gln  Ser Trp Tyr Leu Asp  Arg Ser Leu 
    1205                 1210                 1215             


Arg Lys  Arg Leu His Gln Glu  Tyr Gly Val Gln Gly  Trp Ala Ile 
    1220                 1225                 1230             


Val Gln  Phe Leu Gly Asp Val  Val Phe Ile Pro Ala  Gly Ala Pro 
    1235                 1240                 1245             


His Gln  Val His Asn Leu Tyr  Ser Cys Ile Lys Val  Ala Glu Asp 
    1250                 1255                 1260             


Phe Val  Ser Pro Glu His Val  Lys His Cys Phe Trp  Leu Thr Gln 
    1265                 1270                 1275             


Glu Phe  Arg Tyr Leu Ser Gln  Thr His Thr Asn His  Glu Asp Lys 
    1280                 1285                 1290             


Leu Gln  Val Lys Asn Val Ile  Tyr His Ala Val Lys  Asp Ala Val 
    1295                 1300                 1305             


Ala Met  Leu Lys Ala Ser Glu  Ser Ser Phe Gly Lys  Pro 
    1310                 1315                 1320     


<210>  7781
<211>  6657
<212>  DNA
<213>  Homosapiens

<400>  7781
agcggctccg aggggggcgg gtccgggagg ctgtgcgtgt cttgtgagag ctcttgaacc     60

aagtcagcgc tggagtcggc taggcggctg gaaacggcgg ctgccgccgg tgactcaggg    120

aggcgggagg cgggggagga gctcttcctg caggcgtgga aaccatggtg ctcacgctcg    180

gagaaagttg gccggtattg gtggggagga ggtttctcag tctgtccgca gccgacggca    240

gcgatggcag ccacgacagc tgggacgtgg agcgcgtcgc cgagtggccc tggctctccg    300

ggaccattcg agctgtttcc cacaccgacg ttaccaagaa ggatctgaag gtgtgtgtgg    360

aatttgatgg ggaatcttgg aggaaaagaa gatggataga agtctacagc cttctaagga    420

gagcattttt agtagaacat aatttggttt tagctgaacg aaagtcacct gaaatttctg    480

aacgaattgt acagtggcct gcaataacgt acaaacctct gttggacaaa gctggtttgg    540

gatccataac ttctgttcgc tttctgggag atcaacaaag agtatttctt tctaaagacc    600

ttttgaagcc tatacaggat gtaaacagtc ttcgactttc tcttacggat aatcagattg    660

tcagtaaaga atttcaagct ttgattgtga agcatttaga tgaaagccat cttttaaaag    720

gtgacaaaaa cttagttggt tcagaagtaa aaatttatag cttggaccca tctactcagt    780

ggttttcagc aaccgttata aatggaaacc cagcatcaaa aactcttcaa gtcaactgtg    840

aggagattcc agcactgaaa attgttgatc cgtcactgat tcatgttgaa gttgtacacg    900

ataaccttgt gacatgtggt aattctgcaa gaattggagc tgtaaaacgc aagtcttctg    960

agaataatgg aaccctggtt tccaaacaag caaaatcttg ctctgaggcc tctcccagta   1020

tgtgtcctgt gcagtctgta cctacaacag tttttaagga gatactgctt ggctgtactg   1080

cggcaactcc acctagtaag gacccaagac agcaaagtac tccccaggct gccaactctc   1140

cacctaacct tggagcaaaa attcctcaag gatgtcataa acaaagttta ccagaggaaa   1200

tttcttcctg tctaaataca aagtctgaag ctctgagaac aaaaccagat gtctgcaaag   1260

cagggttgct ctcaaagtcc tctcagattg gaactggaga cttgaaaatt ctgactgagc   1320

caaaaggcag ctgtactcag cctaagacaa acactgatca ggaaaacaga ttggagtctg   1380

ttccacaagc attgactggc cttcctaagg agtgcttacc tacaaaggct tcttctaagg   1440

cagaattgga aattgccaat cctcctgaac tgcagaagca cctagaacat gcaccttccc   1500

catcggatgt ttcaaatgca ccagaagtga aagcaggtgt caatagtgat agccctaata   1560

actgttcagg aaaaaaggta gaaccttcag ctttagcttg ccgatcacag aatttaaagg   1620

aatcttcagt aaaagtagat aatgaaagct gttgttcaag aagcaacaat aaaatccaga   1680

atgccccatc caggaagtcg gttttgacag acccagctaa actcaaaaag ctgcaacaga   1740

gtggcgaggc cttcgtacag gatgattctt gtgtgaacat cgtggcacag ttgcctaaat   1800

gccgagagtg tcgcttggac agtctccgca aggataagga gcaacagaag gactcacctg   1860

tgttttgccg cttctttcac ttcaggaggt tacaattcaa caaacatggt gtgttgcggg   1920

tagaaggctt cttaacacca aacaagtatg acaatgaagc aattggcttg tggttacctt   1980

taaccaaaaa cgttgtgggg attgatttgg acacagcaaa gtacatcttg gccaacattg   2040

gagaccactt ctgtcaaatg gtgatttctg aaaaggaagc tatgtcaact attgagccac   2100

acagacaggt tgcttggaag cgagctgtca aaggtgttcg agaaatgtgt gatgtgtgcg   2160

acaccaccat cttcaacctg cactgggtgt gtcctcggtg tgggtttgga gtatgtgtgg   2220

actgctaccg gatgaagaga aagaattgcc aacagggtga gaaccgattt gattctcctc   2280

cagcccctct acacagttaa atcaagtgtt tttgttgatt tgtgtttggc gggtttcttg   2340

aagcatgtgg agacagagtc tgtaaagaac agttactaca aatcagttat ttgcaggtgc   2400

tgcttacaag actttctctt ggctaaaatg tgtgaagagt cagatacatg aaccagagaa   2460

cttaatgccc acacagatca ttcctggaaa aggtatttca tgtgctgcag tgattttctt   2520

tccccttgtc ttggttaact catgggagct ggtagttttg ttttccttta ttactcgtta   2580

agtttatttt agtgtgtatt gtaagttgtc cagaaatata ttagataatt cctccaacac   2640

ttttcgagtc aagttttgtg ggatagtttt gtagtagaaa agaaaatgca ttttggggaa   2700

ggcctctgga gcaggatgaa aaggagggag tgggaaaagt aatcctgtgg ggaatgccag   2760

cttctgctct gtaatgttga ggttgaaagt tcctaatatc cttgttcaga tgtttgcctc   2820

tgccctttct ttagcactct atgatgttgg agacattgtt cattctgtaa gagcgaaatg   2880

gggaataaag gcaaactgcc cttgttcaaa caggcaattc aaactctttt caaagccagc   2940

ctcaaaggaa gacctaaaac aggtatttac tgcttatgtt aaattcaaca tctcttgtaa   3000

ttgtcatttg tctgtttttc aaataaccca aggatttcta tcagtgcatt tgaaaggaac   3060

ctggggatag ctatcaagtg gaaagagaga gagaaagaat tcatacagtt catgtgacag   3120

ttcagagacc cgttctgact tttcacatta ctttcgtaga ctctactgtg gcctcttgta   3180

gtaggtttta catttttgtt tcttgaagaa gcacaaagtt ctaaagtagt ctacctaata   3240

agtagctgtc gaatttgtaa agggtttaaa aaaatttttt gtgtattttg cagaattaaa   3300

attattaaga taagctttaa catttttaaa attactaaat atattttgcc tgtgtttatg   3360

cagagttgaa ggaaatgatg aaatgaacct ttagttgccc atcacacaat gtaaaaaatg   3420

ttaattttct cagtcctcat atgtctctcc ttggtggcat ccctctcctc cccaccatca   3480

catgtacgtc ttgctgtccc ttctccccct cgttccagta atcagtatgc cgcattgtgt   3540

ttaataatca gaaatttaca tttctataaa gctgtggtgt cataaggcag gatgggagag   3600

cagaagactt gtaatatttg gagtcagaac tgaatttgag ttcttttcct tccacgtgct   3660

agttgtgtta ctttggctga agtgagctgg tttctatgtg cttcagcttc ctcatcagta   3720

atatagaaat aagaagcaat attgatgatt gggcatcaca gaattacatc acatgtaaag   3780

agagggcctg gaccacaaca ggggtttgaa tatttttttt cctccttctt atgtatgtat   3840

aaactcactc ttgccagttt ttaaaattat tttcttctac agcagtcatc ttagatttaa   3900

tttatgggtt cttttaagag ctcatcacat ttttaaagct aagtcaaaat agcattttct   3960

ctttctctgc atcccatttc cttctgaaat caccgcttta cctttcctgc ctgcgtcatt   4020

tattcgtttt taaccatgtt ttctgtgcct atcctgaatt ctgggatgag ttcatagggg   4080

agacaggcac aaactggtca ttttaaacca gcatggtaca tagagtaata gggatatgta   4140

ccagcagggg ctggtgaaag ggtgcggggg gtaatacctt gctgtgttta agttgctgac   4200

atctctccta ccttttagtt attctctact agtgcgggat tactgcagct gtggggatac   4260

ccagggctaa ctattaggtg gttttgttct ggatatttat cttacttgtt ggtcggctat   4320

taggagagaa gaaaagaaaa ggaagctgtc attcttcagc ttatgtaaaa tcgtccttta   4380

atgcttaaca cagacttctt tagctggaga aaaaccgact cttggtgcag tgctccagca   4440

gaatccctca gtgttggagc cagcagctgt gggtggggaa gcagcctcca agccagccgg   4500

cagcatgaag cctgcctgtc cagccagcac atctcctcta aactggctgg ccgacctaac   4560

cagcgggaat gtcaacaagg aaaacaagga aaaacaacca acaatgccaa ttttaaagaa   4620

tgaaatcaaa tgccttccac ccctcccacc tttaagcaaa tccagcacag tcctccatac   4680

gtttaacagc acaattttga cacccgtaag caacaacaat tctggtttcc tccggaatct   4740

cttgaattct tctacaggaa agacagaaaa tggactcaag aatacaccaa aaatccttga   4800

tgacatcttt gcctctttgg tgcaaaataa gacgacttct gatttatcta agaggcctca   4860

aggactaacc atcaagccca gcattctggg ctttgacact cctcactatt ggctttgtga   4920

taatcgcttg ctgtgcttgc aagaccccaa caataagagc aactggaatg tgtttaggga   4980

gtgctggaaa caagggcagc cagtgatggt gtctggagtg catcataaat tgaactctga   5040

actttggaaa cctgaatcct tcaggaaaga gtttggtgag caggaagtag acctagttaa   5100

ttgtaggacc aatgaaatca tcacaggagc cacagtagga gacttctggg atggatttga   5160

agatgttcca aatcgtttga aaaatgaaaa agaaccaatg gtgttgaaac ttaaggactg   5220

gccaccagga gaagatttta gagatatgat gccttccagg tttgatgatc tgatggccaa   5280

cattccactg cccgagtaca caaggcgaga tggcaaactg aatttggcct ctaggctgcc   5340

aaactacttt gttcggccag atctgggccc caagatgtat aatgcttatg gattaatcac   5400

tcctgaagat cggaaatatg gaacaacaaa tcttcactta gatgtatctg atgcagctaa   5460

tgtcatggtc tatgtgggaa ttcccaaagg acagtgtgag caagaagaag aagtccttaa   5520

gaccatccaa gatggagatt ctgacgaact cacaataaag cgatttattg aaggaaaaga   5580

gaagccagga gcactgtggc acatatatgc tgcaaaggac acggagaaga taagggaatt   5640

tcttaaaaag gtatcagaag agcaaggtca agaaaaccca gcagaccacg atcctattca   5700

tgatcaaagc tggtatttag accgatcatt aagaaaacgt cttcatcaag agtatggagt   5760

tcaaggctgg gctattgtac agtttcttgg ggatgtggtg tttatcccgg caggagctcc   5820

acatcaggtt cataacttat atagctgcat caaagtggct gaagattttg tttctccaga   5880

gcatgttaaa cactgcttct ggcttactca ggaattccga tatctgtcac agactcatac   5940

caatcacgaa gataaattac aggtgaagaa tgttatctac catgcagtga aagatgcagt   6000

tgctatgctg aaagccagtg aatccagttt tggcaaacct taatctccct gcacattgga   6060

aatgaattac aggcagctgt tcaaactctt caggcaggat tcctgtggac tttgagattc   6120

atgttacctc atcttctttt ttaaactgta cccaacttgt gagggtactc tgtctaatgt   6180

atatttctag tgtttacaga cagtaaatgt gtatatgtag taactattta cagaacatgc   6240

atccttaaac tgtgacttct cacctagtgc agaactttta ccaggctgta aaagcaaaac   6300

ctcgtatcag ctctggaaca atacctgcag ttattcttca gctgtttgga caacttagat   6360

tgggtttata actattagga atcactgcac agtttatttg ggttgtgttt tgtgtctgag   6420

tcccctccct catcccttag ggtccagaag agcaatggag gaagtgacag ctaatgttgc   6480

agttcttatt gtatggcata ggactggcat tatatagcag aaatcaacta ctgtacaatt   6540

tcttggggtt aaccatcttt agttaaatgg aattttaatt taaatgacgc tttgctaatt   6600

ttaagtgtta agcattttgc attaaaatat tcatataata ttttggctca gtttatt      6657


<210>  7782
<211>  711
<212>  PRT
<213>  Homosapiens

<400>  7782

Met Val Leu Thr Leu Gly Glu Ser Trp Pro Val Leu Val Gly Arg Arg 
1               5                   10                  15      


Phe Leu Ser Leu Ser Ala Ala Asp Gly Ser Asp Gly Ser His Asp Ser 
            20                  25                  30          


Trp Asp Val Glu Arg Val Ala Glu Trp Pro Trp Leu Ser Gly Thr Ile 
        35                  40                  45              


Arg Ala Val Ser His Thr Asp Val Thr Lys Lys Asp Leu Lys Val Cys 
    50                  55                  60                  


Val Glu Phe Asp Gly Glu Ser Trp Arg Lys Arg Arg Trp Ile Glu Val 
65                  70                  75                  80  


Tyr Ser Leu Leu Arg Arg Ala Phe Leu Val Glu His Asn Leu Val Leu 
                85                  90                  95      


Ala Glu Arg Lys Ser Pro Glu Ile Ser Glu Arg Ile Val Gln Trp Pro 
            100                 105                 110         


Ala Ile Thr Tyr Lys Pro Leu Leu Asp Lys Ala Gly Leu Gly Ser Ile 
        115                 120                 125             


Thr Ser Val Arg Phe Leu Gly Asp Gln Gln Arg Val Phe Leu Ser Lys 
    130                 135                 140                 


Asp Leu Leu Lys Pro Ile Gln Asp Val Asn Ser Leu Arg Leu Ser Leu 
145                 150                 155                 160 


Thr Asp Asn Gln Ile Val Ser Lys Glu Phe Gln Ala Leu Ile Val Lys 
                165                 170                 175     


His Leu Asp Glu Ser His Leu Leu Lys Gly Asp Lys Asn Leu Val Gly 
            180                 185                 190         


Ser Glu Val Lys Ile Tyr Ser Leu Asp Pro Ser Thr Gln Trp Phe Ser 
        195                 200                 205             


Ala Thr Val Ile Asn Gly Asn Pro Ala Ser Lys Thr Leu Gln Val Asn 
    210                 215                 220                 


Cys Glu Glu Ile Pro Ala Leu Lys Ile Val Asp Pro Ser Leu Ile His 
225                 230                 235                 240 


Val Glu Val Val His Asp Asn Leu Val Thr Cys Gly Asn Ser Ala Arg 
                245                 250                 255     


Ile Gly Ala Val Lys Arg Lys Ser Ser Glu Asn Asn Gly Thr Leu Val 
            260                 265                 270         


Ser Lys Gln Ala Lys Ser Cys Ser Glu Ala Ser Pro Ser Met Cys Pro 
        275                 280                 285             


Val Gln Ser Val Pro Thr Thr Val Phe Lys Glu Ile Leu Leu Gly Cys 
    290                 295                 300                 


Thr Ala Ala Thr Pro Pro Ser Lys Asp Pro Arg Gln Gln Ser Thr Pro 
305                 310                 315                 320 


Gln Ala Ala Asn Ser Pro Pro Asn Leu Gly Ala Lys Ile Pro Gln Gly 
                325                 330                 335     


Cys His Lys Gln Ser Leu Pro Glu Glu Ile Ser Ser Cys Leu Asn Thr 
            340                 345                 350         


Lys Ser Glu Ala Leu Arg Thr Lys Pro Asp Val Cys Lys Ala Gly Leu 
        355                 360                 365             


Leu Ser Lys Ser Ser Gln Ile Gly Thr Gly Asp Leu Lys Ile Leu Thr 
    370                 375                 380                 


Glu Pro Lys Gly Ser Cys Thr Gln Pro Lys Thr Asn Thr Asp Gln Glu 
385                 390                 395                 400 


Asn Arg Leu Glu Ser Val Pro Gln Ala Leu Thr Gly Leu Pro Lys Glu 
                405                 410                 415     


Cys Leu Pro Thr Lys Ala Ser Ser Lys Ala Glu Leu Glu Ile Ala Asn 
            420                 425                 430         


Pro Pro Glu Leu Gln Lys His Leu Glu His Ala Pro Ser Pro Ser Asp 
        435                 440                 445             


Val Ser Asn Ala Pro Glu Val Lys Ala Gly Val Asn Ser Asp Ser Pro 
    450                 455                 460                 


Asn Asn Cys Ser Gly Lys Lys Val Glu Pro Ser Ala Leu Ala Cys Arg 
465                 470                 475                 480 


Ser Gln Asn Leu Lys Glu Ser Ser Val Lys Val Asp Asn Glu Ser Cys 
                485                 490                 495     


Cys Ser Arg Ser Asn Asn Lys Ile Gln Asn Ala Pro Ser Arg Lys Ser 
            500                 505                 510         


Val Leu Thr Asp Pro Ala Lys Leu Lys Lys Leu Gln Gln Ser Gly Glu 
        515                 520                 525             


Ala Phe Val Gln Asp Asp Ser Cys Val Asn Ile Val Ala Gln Leu Pro 
    530                 535                 540                 


Lys Cys Arg Glu Cys Arg Leu Asp Ser Leu Arg Lys Asp Lys Glu Gln 
545                 550                 555                 560 


Gln Lys Asp Ser Pro Val Phe Cys Arg Phe Phe His Phe Arg Arg Leu 
                565                 570                 575     


Gln Phe Asn Lys His Gly Val Leu Arg Val Glu Gly Phe Leu Thr Pro 
            580                 585                 590         


Asn Lys Tyr Asp Asn Glu Ala Ile Gly Leu Trp Leu Pro Leu Thr Lys 
        595                 600                 605             


Asn Val Val Gly Ile Asp Leu Asp Thr Ala Lys Tyr Ile Leu Ala Asn 
    610                 615                 620                 


Ile Gly Asp His Phe Cys Gln Met Val Ile Ser Glu Lys Glu Ala Met 
625                 630                 635                 640 


Ser Thr Ile Glu Pro His Arg Gln Val Ala Trp Lys Arg Ala Val Lys 
                645                 650                 655     


Gly Val Arg Glu Met Cys Asp Val Cys Asp Thr Thr Ile Phe Asn Leu 
            660                 665                 670         


His Trp Val Cys Pro Arg Cys Gly Phe Gly Val Cys Val Asp Cys Tyr 
        675                 680                 685             


Arg Met Lys Arg Lys Asn Cys Gln Gln Gly Glu Asn Arg Phe Asp Ser 
    690                 695                 700                 


Pro Pro Ala Pro Leu His Ser 
705                 710     


<210>  7783
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  7783
agcggctccg aggggggcgg gtccgggagg ctgtgcgtgt cttgtgagag ctcttgaacc     60

aagtcagcgc tggagtcggc taggcggctg gaaacggcgg ctgccgccgg tgactcaggg    120

aggcgggagg cgggggagga gctcttcctg caggcgtgga aaccatggtg ctcacgctcg    180

gagaaagttg gccggtattg gtggggagga ggtttctcag tctgtccgca gccgacggca    240

gcgatggcag ccacgacagc tgggacgtgg agcgcgtcgc cgagtggccc tggctctccg    300

ggaccattcg agctgtttcc cacaccgacg ttaccaagaa ggatctgaag gtgtgtgtgg    360

aatttgatgg ggaatcttgg aggaaaagaa gatggataga agtctacagc cttctaagga    420

gagcattttt agtagaacat aatttggttt tagctgaacg aaagtcacct gaaatttctg    480

aacgaattgt acagtggcct gcaataacgt acaaacctct gttggacaaa gctggtttgg    540

gatccataac ttctgttcgc tttctgggag atcaacaaag agtatttctt tctaaagacc    600

ttttgaagcc tatacaggat gtaaacagtc ttcgactttc tcttacggat aatcagattg    660

tcagtaaaga atttcaagct ttgattgtga agcatttaga tgaaagccat cttttaaaag    720

gtgacaaaaa cttagttggt tcagaagtaa aaatttatag cttggaccca tctactcagt    780

ggttttcagc aaccgttata aatggaaacc cagcatcaaa aactcttcaa gtcaactgtg    840

aggagattcc agcactgaaa attgttgatc cgtcactgat tcatgttgaa gttgtacacg    900

ataaccttgt gacatgtggt aattctgcaa gaattggagc tgtaaaacgc aagtcttctg    960

agaataatgg aaccctggtt tccaaacaag caaaatcttg ctctgaggcc tctcccagta   1020

tgtgtcctgt gcagtctgta cctacaacag tttttaagga gatactgctt ggctgtactg   1080

cggcaactcc acctagtaag gacccaagac agcaaagtac tccccaggct gccaactctc   1140

cacctaacct tggagcaaaa attcctcaag gatgtcataa acaaagttta ccagaggaaa   1200

tttcttcctg tctaaataca aagtctgaag ctctgagaac aaaaccagat gtctgcaaag   1260

cagggttgct ctcaaagtcc tctcagattg gaactggaga cttgaaaatt ctgactgagc   1320

caaaaggcag ctgtactcag cctaagacaa acactgatca ggaaaacaga ttggagtctg   1380

ttccacaagc attgactggc cttcctaagg agtgcttacc tacaaaggct tcttctaagg   1440

cagaattgga aattgccaat cctcctgaac tgcagaagca cctagaacat gcaccttccc   1500

catcggatgt ttcaaatgca ccagaagtga aagcaggtgt caatagtgat agccctaata   1560

actgttcagg aaaaaaggta gaaccttcag ctttagcttg ccgatcacag aatttaaagg   1620

aatcttcagt aaaagtagat aatgaaagct gttgttcaag aagcaacaat aaaatccaga   1680

atgccccatc caggaagtcg gttttgacag acccagctaa actcaaaaag ctgcaacaga   1740

gtggcgaggc cttcgtacag gatgattctt gtgtgaacat cgtggcacag ttgcctaaat   1800

gccgagagtg tcgcttggac agtctccgca aggataagga gcaacagaag gactcacctg   1860

tgttttgccg cttctttcac ttcaggaggt tacaattcaa caaacatggt gtgttgcggg   1920

tagaaggctt cttaacacca aacaagtatg acaatgaagc aattggcttg tggttacctt   1980

taaccaaaaa cgttgtgggg attgatttgg acacagcaaa gtacatcttg gccaacattg   2040

gagaccactt ctgtcaaatg gtgatttctg aaaaggaagc tatgtcaact attgagccac   2100

acagacaggt tgcttggaag cgagctgtca aaggtgttcg agaaatgtgt gatgtgtgcg   2160

acaccaccat cttcaacctg cactgggtgt gtcctcggtg tgggtttgga gtatgtgtgg   2220

actgctaccg gatgaagaga aagaattgcc aacagggtga gaaccgattt gattctcctc   2280

cagcccctct acacagttaa atcaagtgtt tttgttgatt tgtgtttggc gggtttcttg   2340

aagcatgtgg agacagagtc tgtaaagaac agttactaca aatcagttat ttgcaggtgc   2400

tgcttacaag actttctctt ggctaaaatg tgtgaagagt cagatacatg aaccagagaa   2460

cttaatgccc acacagatca ttcctggaaa agcactctat gatgttggag acattgttca   2520

ttctgtaaga gcgaaatggg gaataaaggc aaactgccct tgttcaaaca ggcaattcaa   2580

actcttttca aagccagcct caaaggaaga cctaaaacag gtatttactg cttatgttaa   2640

attcaacatc tcttgtaatt gtcatttgtc tgtttttcaa ataacccaag gatttctatc   2700

agtgcatttg aaaggaacct ggggatagct atcaagtgga aagagagaga gaaagaattc   2760

atacagttca tgtgacagtt cagagacccg ttctgacttt tcacattact ttcgtagact   2820

ctactgtggc ctcttgtagt aggttttaca tttttgtttc ttgaagaagc acaaagttct   2880

aaagtagtct acctaataag tagctgtcga atttgtaaag ggtttaaaaa aattttttgt   2940

gtattttgca gaattaaaat tattaagata agctttaaca tttttaaaat tactaaatat   3000

attttgcctg tgtttatgca gagttgaagg aaatgatgaa atgaaccttt agttgcccat   3060

cacacaatgt aaaaaatgtt aattttctca gtcctcatat gtctctcctt ggtggcatcc   3120

ctctcctccc caccatcaca tgtacgtctt gctgtccctt ctccccctcg ttccagtaat   3180

cagtatgccg cattgtgttt aataatcaga aatttacatt tctataaagc tgtggtgtca   3240

taaggcagga tgggagagca gaagacttgt aatatttgga gtcagaactg aatttgagtt   3300

cttttccttc cacgtgctag ttgtgttact ttggctgaag tgagctggtt tctatgtgct   3360

tcagcttcct catcagtaat atagaaataa gaagcaatat tgatgattgg gcatcacaga   3420

attacatcac atgtaaagag agggcctgga ccacaacagg ggtttgaata ttttttttcc   3480

tccttcttat gtatgtataa actcactctt gccagttttt aaaattattt tcttctacag   3540

cagtcatctt agatttaatt tatgggttct tttaagagct catcacattt ttaaagctaa   3600

gtcaaaatag cattttctct ttctctgcat cccatttcct tctgaaatca ccgctttacc   3660

tttcctgcct gcgtcattta ttcgttttta accatgtttt ctgtgcctat cctgaattct   3720

gggatgagtt cataggggag acaggcacaa actggtcatt ttaaaccagc atggtacata   3780

gagtaatagg gatatgtacc agcaggggct ggtgaaaggg tgcggggggt aataccttgc   3840

tgtgtttaag ttgctgacat ctctcctacc ttttagttat tctctactag tgcgggatta   3900

ctgcagctgt ggggataccc agggctaact attaggtggt tttgttctgg atatttatct   3960

tacttgttgg tcggctatta ggagagaaga aaagaaaagg aagctgtcat tcttcagctt   4020

atgtaaaatc gtcctttaat gcttaacaca gacttcttta gctggagaaa aaccgactct   4080

tggtgcagtg ctccagcaga atccctcagt gttggagcca gcagctgtgg gtggggaagc   4140

agcctccaag ccagccggca gcatgaagcc tgcctgtcca gccagcacat ctcctctaaa   4200

ctggctggcc gacctaacca gcgggaatgt caacaaggaa aacaaggaaa aacaaccaac   4260

aatgccaatt ttaaagaatg aaatcaaatg ccttccaccc ctcccacctt taagcaaatc   4320

cagcacagtc ctccatacgt ttaacagcac aattttgaca cccgtaagca acaacaattc   4380

tggtttcctc cggaatctct tgaattcttc tacaggaaag acagaaaatg gactcaagaa   4440

tacaccaaaa atccttgatg acatctttgc ctctttggtg caaaataaga cgacttctga   4500

tttatctaag aggcctcaag gactaaccat caagcccagc attctgggct ttgacactcc   4560

tcactattgg ctttgtgata atcgcttgct gtgcttgcaa gaccccaaca ataagagcaa   4620

ctggaatgtg tttagggagt gctggaaaca agggcaggta atgtaggcct cccatcctcc   4680

tgccctattc agaaccccct tctcagttcc tttagcagac ttctgacaac cccaccccag   4740

gctttccccc tccttcacct cctgttttat tctttattgt ttcaggtgaa tataatcagg   4800

tcaggatgtg gccatgggtc ttacttttta aagcagatgg tcctaagctg gacttttcca   4860

gtcaggtttt tgttgcttcc taccagtccc tgttgggttt ttgacgaggg catccaggct   4920

tggtgattcc tatggtaaac ttcagcagag gaagtgaggg tgtgactaca ggctgatggg   4980

atttgggaga tcagacaaaa tgtgctacaa aatcatgcac ccctcttacc tgaatgaaaa   5040

gcctgtgctg aaggcagttc taggtgggct agggccgcgt ggtgtcacat agtccccagg   5100

tgcctgcttc aaagggcagt gttgttggat cttaagtgcc ggttaatatc tttaggagaa   5160

tttctaggcc tgcttctgtg ctttcttgtt ttggttctgt tttctggatc tctggcttct   5220

ctgtttggcc agatagggtc tttgctaaag gaacactctg ctcttggaca agaatttggg   5280

agaattgcca aacagaaaga tgtgagtgtt taaccaaaaa taaatttcca aaatgttttt   5340

ctccatccag tgtactaata ggatttgctc atttaatcat atatagacaa gaaacaaaat   5400

gatgggctga atacagttta tcggcaggct ttctttcttg cttgtcaata ttttaatgtt   5460

agactatttc acataaaggt tagagcttct gggttgtctt agacggccaa aagatttggc   5520

accctcacac agccagtagt agtgaggggt gtcacaggcc atattcctgc ttggcaataa   5580

caggctcaag tacggtgggg tcagtcaccc tgtttcactg gtgactggtg tcactggaca   5640

ctccttccag cgcttgtctt cttcacagtc cgtcttgctg taagtaatga gatcttacta   5700

ggagaggtga tcctttctcc tagatgctta cccatgtagt ttgagagcaa gggtgtgtag   5760

cagatgaatg gtgaaggttg gaggtgcttt gggagctcag agaactaagc cgaaactgtc   5820

acatcaccat ctgagacgga gcaccagctc catggaaata taccaatagc agtgtgaaga   5880

gggactgcct tcgggagtgg ggacagagct ggcagagttc agactaaagt tttccttctc   5940

ttcatttagc cagtgatggt gtctggagtg catcataaat tgaactctga actttggaaa   6000

cctgaatcct tcaggaaaga gtttggtgag caggaagtag acctagttaa ttgtaggacc   6060

aatgaaatca tcacaggagc cacagtagga gacttctggg atggatttga agatgttcca   6120

aatcgtttga aaaatgaaaa agaaccaatg gtgttgaaac ttaaggactg gccaccagga   6180

gaagatttta gagatatgat gccttccagg tttgatgatc tgatggccaa cattccactg   6240

cccgagtaca caaggcgaga tggcaaactg aatttggcct ctaggctgcc aaactacttt   6300

gttcggccag atctgggccc caagatgtat aatgcttatg gattaatcac tcctgaagat   6360

cggaaatatg gaacaacaaa tcttcactta gatgtatctg atgcagctaa tgtcatggtc   6420

tatgtgggaa ttcccaaagg acagtgtgag caagaagaag aagtccttaa gaccatccaa   6480

gatggagatt ctgacgaact cacaataaag cgatttattg aaggaaaaga gaagccagga   6540

gcactgtggc acatatatgc tgcaaaggac acggagaaga taagggaatt tcttaaaaag   6600

gtgtgctgct tatggcatgt gtgaacagag gcataaggaa tagcaatatt atgttactac   6660

atgtggtgaa ctgactggct tggctagggg aattgtcaca acctgaaaag ttaaatctgt   6720

acctgtcaga ttgaataggc tgaaggtggt tgctaaggaa caaggattct aaatgattag   6780

ggttacactt ctaaaaaaag caggccttgt cttttatgtc tgtgttttgt gttagagtgc   6840

atttagagat ttttgttctc tgctttcaag ttagaagtta gttcatctga tcatctccca   6900

gcatatatct gtttttattg ccttgagaat ctgagcactt cagacgttca tgtatccttg   6960

gccctgagtg accatgttct gagtgagttg ctaagtttgg ttttgtccac tgtcatgtag   7020

caagtggtcc tacttgttac tagcaagggt tgcagggatt tggaagattc taggtttccc   7080

ctgtagttgg caggtttttt tttcagcaag ggctatgtgt ggaaattcta ggcaactaga   7140

aagatgagtc gtgttcagtt ttaaaattgt ttggcactga ggctgccggt tgcaactcag   7200

gtgtctttgg ctgatattct tcagtcattc atgagtcttg gatatgaaca ttcgtaacct   7260

gttagctggc cccaagtatg tctttaacaa gcatttgttt gaatcaaagt gtttctggct   7320

aaggatcatt tggctcttcc agaaaaccgg cttggtcacc atattgttct tttgatattg   7380

tcactctgag tctctgcttt accagttact ggatcaagga taaacaagtc taatctgcag   7440

ctgtctttgg gactgtttcg taagtcagat taagtaaagg caggtttcta ataactttaa   7500

aacaagttca tttataagga tactgagcct acttatgttt aaaaatctag actaaaatat   7560

tgtttaaata cagtatttac aaacttatgc agagcctgtc agtcatggtt tatgggaact   7620

gacatcacat tttcttcgtc attcttctgt tggttcattc agctgaagtc tttgatacta   7680

ctagtcgtct tctgccaatg ggggcactta agttgaagaa ggcctgacat ttatgaactg   7740

ccaacactgt ttagaggaaa aaaatggctt attgggcctt agcatgttac tgagttgcat   7800

aatattttga atgtattcta ggtatcagaa gagcaaggtc aagaaaaccc agcagaccac   7860

gatcctattc atgatcaaag ctggtattta gaccgatcat taagaaaacg tcttcatcaa   7920

gagtatggag ttcaaggctg ggctattgta cagtttcttg gggatgtggt gtttatcccg   7980

gcaggagctc cacatcaggt tcataactta tatagctgca tcaaagtggc tgaagatttt   8040

gtttctccag agcatgttaa acactgcttc tggcttactc aggaattccg atatctgtca   8100

cagactcata ccaatcacga agataaatta caggtgaaga atgttatcta ccatgcagtg   8160

aaagatgcag ttgctatgct gaaagccagt ga                                 8192


<210>  7784
<211>  711
<212>  PRT
<213>  Homosapiens

<400>  7784

Met Val Leu Thr Leu Gly Glu Ser Trp Pro Val Leu Val Gly Arg Arg 
1               5                   10                  15      


Phe Leu Ser Leu Ser Ala Ala Asp Gly Ser Asp Gly Ser His Asp Ser 
            20                  25                  30          


Trp Asp Val Glu Arg Val Ala Glu Trp Pro Trp Leu Ser Gly Thr Ile 
        35                  40                  45              


Arg Ala Val Ser His Thr Asp Val Thr Lys Lys Asp Leu Lys Val Cys 
    50                  55                  60                  


Val Glu Phe Asp Gly Glu Ser Trp Arg Lys Arg Arg Trp Ile Glu Val 
65                  70                  75                  80  


Tyr Ser Leu Leu Arg Arg Ala Phe Leu Val Glu His Asn Leu Val Leu 
                85                  90                  95      


Ala Glu Arg Lys Ser Pro Glu Ile Ser Glu Arg Ile Val Gln Trp Pro 
            100                 105                 110         


Ala Ile Thr Tyr Lys Pro Leu Leu Asp Lys Ala Gly Leu Gly Ser Ile 
        115                 120                 125             


Thr Ser Val Arg Phe Leu Gly Asp Gln Gln Arg Val Phe Leu Ser Lys 
    130                 135                 140                 


Asp Leu Leu Lys Pro Ile Gln Asp Val Asn Ser Leu Arg Leu Ser Leu 
145                 150                 155                 160 


Thr Asp Asn Gln Ile Val Ser Lys Glu Phe Gln Ala Leu Ile Val Lys 
                165                 170                 175     


His Leu Asp Glu Ser His Leu Leu Lys Gly Asp Lys Asn Leu Val Gly 
            180                 185                 190         


Ser Glu Val Lys Ile Tyr Ser Leu Asp Pro Ser Thr Gln Trp Phe Ser 
        195                 200                 205             


Ala Thr Val Ile Asn Gly Asn Pro Ala Ser Lys Thr Leu Gln Val Asn 
    210                 215                 220                 


Cys Glu Glu Ile Pro Ala Leu Lys Ile Val Asp Pro Ser Leu Ile His 
225                 230                 235                 240 


Val Glu Val Val His Asp Asn Leu Val Thr Cys Gly Asn Ser Ala Arg 
                245                 250                 255     


Ile Gly Ala Val Lys Arg Lys Ser Ser Glu Asn Asn Gly Thr Leu Val 
            260                 265                 270         


Ser Lys Gln Ala Lys Ser Cys Ser Glu Ala Ser Pro Ser Met Cys Pro 
        275                 280                 285             


Val Gln Ser Val Pro Thr Thr Val Phe Lys Glu Ile Leu Leu Gly Cys 
    290                 295                 300                 


Thr Ala Ala Thr Pro Pro Ser Lys Asp Pro Arg Gln Gln Ser Thr Pro 
305                 310                 315                 320 


Gln Ala Ala Asn Ser Pro Pro Asn Leu Gly Ala Lys Ile Pro Gln Gly 
                325                 330                 335     


Cys His Lys Gln Ser Leu Pro Glu Glu Ile Ser Ser Cys Leu Asn Thr 
            340                 345                 350         


Lys Ser Glu Ala Leu Arg Thr Lys Pro Asp Val Cys Lys Ala Gly Leu 
        355                 360                 365             


Leu Ser Lys Ser Ser Gln Ile Gly Thr Gly Asp Leu Lys Ile Leu Thr 
    370                 375                 380                 


Glu Pro Lys Gly Ser Cys Thr Gln Pro Lys Thr Asn Thr Asp Gln Glu 
385                 390                 395                 400 


Asn Arg Leu Glu Ser Val Pro Gln Ala Leu Thr Gly Leu Pro Lys Glu 
                405                 410                 415     


Cys Leu Pro Thr Lys Ala Ser Ser Lys Ala Glu Leu Glu Ile Ala Asn 
            420                 425                 430         


Pro Pro Glu Leu Gln Lys His Leu Glu His Ala Pro Ser Pro Ser Asp 
        435                 440                 445             


Val Ser Asn Ala Pro Glu Val Lys Ala Gly Val Asn Ser Asp Ser Pro 
    450                 455                 460                 


Asn Asn Cys Ser Gly Lys Lys Val Glu Pro Ser Ala Leu Ala Cys Arg 
465                 470                 475                 480 


Ser Gln Asn Leu Lys Glu Ser Ser Val Lys Val Asp Asn Glu Ser Cys 
                485                 490                 495     


Cys Ser Arg Ser Asn Asn Lys Ile Gln Asn Ala Pro Ser Arg Lys Ser 
            500                 505                 510         


Val Leu Thr Asp Pro Ala Lys Leu Lys Lys Leu Gln Gln Ser Gly Glu 
        515                 520                 525             


Ala Phe Val Gln Asp Asp Ser Cys Val Asn Ile Val Ala Gln Leu Pro 
    530                 535                 540                 


Lys Cys Arg Glu Cys Arg Leu Asp Ser Leu Arg Lys Asp Lys Glu Gln 
545                 550                 555                 560 


Gln Lys Asp Ser Pro Val Phe Cys Arg Phe Phe His Phe Arg Arg Leu 
                565                 570                 575     


Gln Phe Asn Lys His Gly Val Leu Arg Val Glu Gly Phe Leu Thr Pro 
            580                 585                 590         


Asn Lys Tyr Asp Asn Glu Ala Ile Gly Leu Trp Leu Pro Leu Thr Lys 
        595                 600                 605             


Asn Val Val Gly Ile Asp Leu Asp Thr Ala Lys Tyr Ile Leu Ala Asn 
    610                 615                 620                 


Ile Gly Asp His Phe Cys Gln Met Val Ile Ser Glu Lys Glu Ala Met 
625                 630                 635                 640 


Ser Thr Ile Glu Pro His Arg Gln Val Ala Trp Lys Arg Ala Val Lys 
                645                 650                 655     


Gly Val Arg Glu Met Cys Asp Val Cys Asp Thr Thr Ile Phe Asn Leu 
            660                 665                 670         


His Trp Val Cys Pro Arg Cys Gly Phe Gly Val Cys Val Asp Cys Tyr 
        675                 680                 685             


Arg Met Lys Arg Lys Asn Cys Gln Gln Gly Glu Asn Arg Phe Asp Ser 
    690                 695                 700                 


Pro Pro Ala Pro Leu His Ser 
705                 710     


<210>  7785
<211>  5947
<212>  DNA
<213>  Homosapiens

<400>  7785
agcggctccg aggggggcgg gtccgggagg ctgtgcgtgt cttgtgagag ctcttgaacc     60

aagtcagcgc tggagtcggc taggcggctg gaaacggcgg ctgccgccgg tgactcaggg    120

aggcgggagg cgggggagga gctcttcctg caggcgtgga aaccatggtg ctcacgctcg    180

gagaaagttg gccggtattg gtggggagga ggtttctcag tctgtccgca gccgacggca    240

gcgatggcag ccacgacagc tgggacgtgg agcgcgtcgc cgagtggccc tggctctccg    300

ggaccattcg agctgtttcc cacaccgacg ttaccaagaa ggatctgaag gtgtgtgtgg    360

aatttgatgg ggaatcttgg aggaaaagaa gatggataga agtctacagc cttctaagga    420

gagcattttt agtagaacat aatttggttt tagctgaacg aaagtcacct gaaatttctg    480

aacgaattgt acagtggcct gcaataacgt acaaacctct gttggacaaa gctggtttgg    540

gatccataac ttctgttcgc tttctgggag atcaacaaag agtatttctt tctaaagacc    600

ttttgaagcc tatacaggat gtaaacagtc ttcgactttc tcttacggat aatcagattg    660

tcagtaaaga atttcaagct ttgattgtga agcatttaga tgaaagccat cttttaaaag    720

gtgacaaaaa cttagttggt tcagaagtaa aaatttatag cttggaccca tctactcagt    780

ggttttcagc aaccgttata aatggaaacc cagcatcaaa aactcttcaa gtcaactgtg    840

aggagattcc agcactgaaa attgttgatc cgtcactgat tcatgttgaa gttgtacacg    900

ataaccttgt gacatgtggt aattctgcaa gaattggagc tgtaaaacgc aagtcttctg    960

agaataatgg aaccctggtt tccaaacaag caaaatcttg ctctgaggcc tctcccagta   1020

tgtgtcctgt gcagtctgta cctacaacag tttttaagga gatactgctt ggctgtactg   1080

cggcaactcc acctagtaag gacccaagac agcaaagtac tccccaggct gccaactctc   1140

cacctaacct tggagcaaaa attcctcaag gatgtcataa acaaagttta ccagaggaaa   1200

tttcttcctg tctaaataca aagtctgaag ctctgagaac aaaaccagat gtctgcaaag   1260

cagggttgct ctcaaagtcc tctcagattg gaactggaga cttgaaaatt ctgactgagc   1320

caaaaggcag ctgtactcag cctaagacaa acactgatca ggaaaacaga ttggagtctg   1380

ttccacaagc attgactggc cttcctaagg agtgcttacc tacaaaggct tcttctaagg   1440

cagaattgga aattgccaat cctcctgaac tgcagaagca cctagaacat gcaccttccc   1500

catcggatgt ttcaaatgca ccagaagtga aagcaggtgt caatagtgat agccctaata   1560

actgttcagg aaaaaaggta gaaccttcag ctttagcttg ccgatcacag aatttaaagg   1620

aatcttcagt aaaagtagat aatgaaagct gttgttcaag aagcaacaat aaaatccaga   1680

atgccccatc caggaagtcg gttttgacag acccagctaa actcaaaaag ctgcaacaga   1740

gtggcgaggc cttcgtacag gatgattctt gtgtgaacat cgtggcacag ttgcctaaat   1800

gccgagagtg tcgcttggac agtctccgca aggataagga gcaacagaag gactcacctg   1860

tgttttgccg cttctttcac ttcaggaggt tacaattcaa caaacatggt gtgttgcggg   1920

tagaaggctt cttaacacca aacaagtatg acaatgaagc aattggcttg tggttacctt   1980

taaccaaaaa cgttgtgggg attgatttgg acacagcaaa gtacatcttg gccaacattg   2040

gagaccactt ctgtcaaatg gtgatttctg aaaaggaagc tatgtcaact attgagccac   2100

acagacaggt tgcttggaag cgagctgtca aaggtgttcg agaaatgtgt gatgtgtgcg   2160

acaccaccat cttcaacctg cactgggtgt gtcctcggtg tgggtttgga gtatgtgtgg   2220

actgctaccg gatgaagaga aagaattgcc aacagggtgc tgcttacaag actttctctt   2280

ggctaaaatg tgtgaagagt cagatacatg aaccagagaa cttaatgccc acacagatca   2340

ttcctggaaa agcactctat gatgttggag acattgttca ttctgtaaga gcgaaatggg   2400

gaataaaggc aaactgccct tgttcaaaca ggcaattcaa actcttttca aagccagcct   2460

caaaggaaga cctaaaacag acttctttag ctggagaaaa accgactctt ggtgcagtgc   2520

tccagcagaa tccctcagtg ttggagccag cagctgtggg tggggaagca gcctccaagc   2580

cagccggcag catgaagcct gcctgtccag ccagcacatc tcctctaaac tggctggccg   2640

acctaaccag cgggaatgtc aacaaggaaa acaaggaaaa acaaccaaca atgccaattt   2700

taaagaatga aatcaaatgc cttccacccc tcccaccttt aagcaaatcc agcacagtcc   2760

tccatacgtt taacagcaca attttgacac ccgtaagcaa caacaattct ggtttcctcc   2820

ggaatctctt gaattcttct acaggaaaga cagaaaatgg actcaagaat acaccaaaaa   2880

tccttgatga catctttgcc tctttggtgc aaaataagac gacttctgat ttatctaaga   2940

ggcctcaagg actaaccatc aagcccagca ttctgggctt tgacactcct cactattggc   3000

tttgtgataa tcgcttgctg tgcttgcaag accccaacaa taagagcaac tggaatgtgt   3060

ttagggagtg ctggaaacaa gggcagccag tgatggtgtc tggagtgcat cataaattga   3120

actctgaact ttggaaacct gaatccttca ggaaagagtt tggtgagcag gaagtagacc   3180

tagttaattg taggaccaat gaaatcatca caggagccac agtaggagac ttctgggatg   3240

gatttgaaga tgttccaaat cgtttgaaaa atgaaaaaga accaatggtg ttgaaactta   3300

aggactggcc accaggagaa gattttagag atatgatgcc ttccaggttt gatgatctga   3360

tggccaacat tccactgccc gagtacacaa ggcgagatgg caaactgaat ttggcctcta   3420

ggctgccaaa ctactttgtt cggccagatc tgggccccaa gatgtataat gcttatggat   3480

taatcactcc tgaagatcgg aaatatggaa caacaaatct tcacttagat gtatctgatg   3540

cagctaatgt catggtctat gtgggaattc ccaaaggaca gtgtgagcaa gaagaagaag   3600

tccttaagac catccaagat ggagattctg acgaactcac aataaagcga tttattgaag   3660

gaaaagagaa gccaggagca ctgtggcaca tatatgctgc aaaggacacg gagaagataa   3720

gggaatttct taaaaaggta tcagaagagc aaggtcaaga aaacccagca gaccacgatc   3780

ctattcatga tcaaagctgg tatttagacc gatcattaag aaaacgtctt catcaagagt   3840

atggagttca aggctgggct attgtacagt ttcttgggga tgtggtgttt atcccggcag   3900

gagctccaca tcaggttcat aacttatata gctgcatcaa agtggctgaa gattttgttt   3960

ctccagagca tgttaaacac tgcttctggc ttactcagga attccgatat ctgtcacaga   4020

ctcataccaa tcacgaagat aaattacagg tgaagaatgt tatctaccat gcagtgaaag   4080

atgcagttgc tatgctgaaa gccagtgaat ccagttttgg caaaccttaa tctccctgca   4140

cattggaaat gaattacagg cagctgttca aactcttcag gcaggattcc tgtggacttt   4200

gagattcatg ttacctcatc ttctttttta aactgtaccc aacttgtgag ggtactctgt   4260

ctaatgtata tttctagtgt ttacagacag taaatgtgta tatgtagtaa ctatttacag   4320

aacatgcatc cttaaactgt gacttctcac ctagtgcaga acttttacca ggctgtaaaa   4380

gcaaaacctc gtatcagctc tggaacaata cctgcagtta ttcttcagct gtttggacaa   4440

cttagattgg gtttataact attaggaatc actgcacagt ttatttgggt tgtgttttgt   4500

gtctgagtcc cctccctcat cccttagggt ccagaagagc aatggaggaa gtgacagcta   4560

atgttgcagt tcttattgta tggcatagga ctggcattat atagcagaaa tcaactactg   4620

tacaatttct tggggttaac catctttagt taaatggaat tttaatttaa atgacgcttt   4680

gctaatttta agtgttaagc attttgcatt aaaatattca tataatattt tggctcagtt   4740

tattggcatt atcctctcat tgtggtttca acacaacttt cttcaaatgc aggtgtaatg   4800

gattgctcca agaactcttc ttaaaagcaa agaaatcaga tgctatagtg attttcttag   4860

tgattattac aaagctaaca tggaaatttc tgctcagcca ggtagaaacc ctgtcacact   4920

ttgtcaagga aacaccacca attaattaaa tttagaaaca ggaattaacc aagaaaccaa   4980

atagtgccag gctaaatggt tctaaaaagg taagtaatga aacactttgt tttatggccc   5040

ttcataatgt taagtttatg aaggaaaatg aaattataag ttctaggaca gtactaccta   5100

aaatattcat ctctgtgaag gaaaaaaatt cacaaagaag cgcctttctt tagcccactg   5160

attctcctag gccactcttt catttaattt ctttaaaaaa aggaattaaa catagaaatc   5220

agatagtaca tagacaaagc ctagaacctg agttttaatt tgtgagctga gtaggaggcc   5280

agaggatccg tattaaattt cagaacccat tgtcaaatct aaggtcaaag atttgctcta   5340

atgttttctt ctaggagttt taaaatttta gcccttaaat taagtctttg acctattttg   5400

agttaattat taaatatggt gtaaagattc aacttcattt ttttgaatat ggatatccag   5460

ttttcccagc aacatttgtc gtcaaacact gttctttccc ccattgaatg gtcttggcac   5520

tctagttaaa aatcaattga tcgtagatgg gaaagcatat tactaggctc tcatattcca   5580

ctggtctgtg tatctgtctt tatgccagta ctgcactgtt ttgatttctg ctactttgta   5640

gtaagtttta aaatcaacaa ctgtgagttc tccaactctg gtcttctttt tcatgattgt   5700

tttaatcagg gtcactggaa attccgtacg aattttggga taggtttttt tatttctgca   5760

aaaaacacca tctgggtatt aatagagatt gcattgaacc tgtatgttcc tttgggtgtc   5820

atcttaacaa tctaattctt gcaatccatg agcatgggat gttgtgtttc catttattgg   5880

tgtcttcttt aatgtctttc agcaatgttt tgtagttttc agttgcatga gttttgtacc   5940

ttcatgg                                                             5947


<210>  7786
<211>  1321
<212>  PRT
<213>  Homosapiens

<400>  7786

Met Val Leu Thr Leu Gly Glu Ser Trp Pro Val Leu Val Gly Arg Arg 
1               5                   10                  15      


Phe Leu Ser Leu Ser Ala Ala Asp Gly Ser Asp Gly Ser His Asp Ser 
            20                  25                  30          


Trp Asp Val Glu Arg Val Ala Glu Trp Pro Trp Leu Ser Gly Thr Ile 
        35                  40                  45              


Arg Ala Val Ser His Thr Asp Val Thr Lys Lys Asp Leu Lys Val Cys 
    50                  55                  60                  


Val Glu Phe Asp Gly Glu Ser Trp Arg Lys Arg Arg Trp Ile Glu Val 
65                  70                  75                  80  


Tyr Ser Leu Leu Arg Arg Ala Phe Leu Val Glu His Asn Leu Val Leu 
                85                  90                  95      


Ala Glu Arg Lys Ser Pro Glu Ile Ser Glu Arg Ile Val Gln Trp Pro 
            100                 105                 110         


Ala Ile Thr Tyr Lys Pro Leu Leu Asp Lys Ala Gly Leu Gly Ser Ile 
        115                 120                 125             


Thr Ser Val Arg Phe Leu Gly Asp Gln Gln Arg Val Phe Leu Ser Lys 
    130                 135                 140                 


Asp Leu Leu Lys Pro Ile Gln Asp Val Asn Ser Leu Arg Leu Ser Leu 
145                 150                 155                 160 


Thr Asp Asn Gln Ile Val Ser Lys Glu Phe Gln Ala Leu Ile Val Lys 
                165                 170                 175     


His Leu Asp Glu Ser His Leu Leu Lys Gly Asp Lys Asn Leu Val Gly 
            180                 185                 190         


Ser Glu Val Lys Ile Tyr Ser Leu Asp Pro Ser Thr Gln Trp Phe Ser 
        195                 200                 205             


Ala Thr Val Ile Asn Gly Asn Pro Ala Ser Lys Thr Leu Gln Val Asn 
    210                 215                 220                 


Cys Glu Glu Ile Pro Ala Leu Lys Ile Val Asp Pro Ser Leu Ile His 
225                 230                 235                 240 


Val Glu Val Val His Asp Asn Leu Val Thr Cys Gly Asn Ser Ala Arg 
                245                 250                 255     


Ile Gly Ala Val Lys Arg Lys Ser Ser Glu Asn Asn Gly Thr Leu Val 
            260                 265                 270         


Ser Lys Gln Ala Lys Ser Cys Ser Glu Ala Ser Pro Ser Met Cys Pro 
        275                 280                 285             


Val Gln Ser Val Pro Thr Thr Val Phe Lys Glu Ile Leu Leu Gly Cys 
    290                 295                 300                 


Thr Ala Ala Thr Pro Pro Ser Lys Asp Pro Arg Gln Gln Ser Thr Pro 
305                 310                 315                 320 


Gln Ala Ala Asn Ser Pro Pro Asn Leu Gly Ala Lys Ile Pro Gln Gly 
                325                 330                 335     


Cys His Lys Gln Ser Leu Pro Glu Glu Ile Ser Ser Cys Leu Asn Thr 
            340                 345                 350         


Lys Ser Glu Ala Leu Arg Thr Lys Pro Asp Val Cys Lys Ala Gly Leu 
        355                 360                 365             


Leu Ser Lys Ser Ser Gln Ile Gly Thr Gly Asp Leu Lys Ile Leu Thr 
    370                 375                 380                 


Glu Pro Lys Gly Ser Cys Thr Gln Pro Lys Thr Asn Thr Asp Gln Glu 
385                 390                 395                 400 


Asn Arg Leu Glu Ser Val Pro Gln Ala Leu Thr Gly Leu Pro Lys Glu 
                405                 410                 415     


Cys Leu Pro Thr Lys Ala Ser Ser Lys Ala Glu Leu Glu Ile Ala Asn 
            420                 425                 430         


Pro Pro Glu Leu Gln Lys His Leu Glu His Ala Pro Ser Pro Ser Asp 
        435                 440                 445             


Val Ser Asn Ala Pro Glu Val Lys Ala Gly Val Asn Ser Asp Ser Pro 
    450                 455                 460                 


Asn Asn Cys Ser Gly Lys Lys Val Glu Pro Ser Ala Leu Ala Cys Arg 
465                 470                 475                 480 


Ser Gln Asn Leu Lys Glu Ser Ser Val Lys Val Asp Asn Glu Ser Cys 
                485                 490                 495     


Cys Ser Arg Ser Asn Asn Lys Ile Gln Asn Ala Pro Ser Arg Lys Ser 
            500                 505                 510         


Val Leu Thr Asp Pro Ala Lys Leu Lys Lys Leu Gln Gln Ser Gly Glu 
        515                 520                 525             


Ala Phe Val Gln Asp Asp Ser Cys Val Asn Ile Val Ala Gln Leu Pro 
    530                 535                 540                 


Lys Cys Arg Glu Cys Arg Leu Asp Ser Leu Arg Lys Asp Lys Glu Gln 
545                 550                 555                 560 


Gln Lys Asp Ser Pro Val Phe Cys Arg Phe Phe His Phe Arg Arg Leu 
                565                 570                 575     


Gln Phe Asn Lys His Gly Val Leu Arg Val Glu Gly Phe Leu Thr Pro 
            580                 585                 590         


Asn Lys Tyr Asp Asn Glu Ala Ile Gly Leu Trp Leu Pro Leu Thr Lys 
        595                 600                 605             


Asn Val Val Gly Ile Asp Leu Asp Thr Ala Lys Tyr Ile Leu Ala Asn 
    610                 615                 620                 


Ile Gly Asp His Phe Cys Gln Met Val Ile Ser Glu Lys Glu Ala Met 
625                 630                 635                 640 


Ser Thr Ile Glu Pro His Arg Gln Val Ala Trp Lys Arg Ala Val Lys 
                645                 650                 655     


Gly Val Arg Glu Met Cys Asp Val Cys Asp Thr Thr Ile Phe Asn Leu 
            660                 665                 670         


His Trp Val Cys Pro Arg Cys Gly Phe Gly Val Cys Val Asp Cys Tyr 
        675                 680                 685             


Arg Met Lys Arg Lys Asn Cys Gln Gln Gly Ala Ala Tyr Lys Thr Phe 
    690                 695                 700                 


Ser Trp Leu Lys Cys Val Lys Ser Gln Ile His Glu Pro Glu Asn Leu 
705                 710                 715                 720 


Met Pro Thr Gln Ile Ile Pro Gly Lys Ala Leu Tyr Asp Val Gly Asp 
                725                 730                 735     


Ile Val His Ser Val Arg Ala Lys Trp Gly Ile Lys Ala Asn Cys Pro 
            740                 745                 750         


Cys Ser Asn Arg Gln Phe Lys Leu Phe Ser Lys Pro Ala Ser Lys Glu 
        755                 760                 765             


Asp Leu Lys Gln Thr Ser Leu Ala Gly Glu Lys Pro Thr Leu Gly Ala 
    770                 775                 780                 


Val Leu Gln Gln Asn Pro Ser Val Leu Glu Pro Ala Ala Val Gly Gly 
785                 790                 795                 800 


Glu Ala Ala Ser Lys Pro Ala Gly Ser Met Lys Pro Ala Cys Pro Ala 
                805                 810                 815     


Ser Thr Ser Pro Leu Asn Trp Leu Ala Asp Leu Thr Ser Gly Asn Val 
            820                 825                 830         


Asn Lys Glu Asn Lys Glu Lys Gln Pro Thr Met Pro Ile Leu Lys Asn 
        835                 840                 845             


Glu Ile Lys Cys Leu Pro Pro Leu Pro Pro Leu Ser Lys Ser Ser Thr 
    850                 855                 860                 


Val Leu His Thr Phe Asn Ser Thr Ile Leu Thr Pro Val Ser Asn Asn 
865                 870                 875                 880 


Asn Ser Gly Phe Leu Arg Asn Leu Leu Asn Ser Ser Thr Gly Lys Thr 
                885                 890                 895     


Glu Asn Gly Leu Lys Asn Thr Pro Lys Ile Leu Asp Asp Ile Phe Ala 
            900                 905                 910         


Ser Leu Val Gln Asn Lys Thr Thr Ser Asp Leu Ser Lys Arg Pro Gln 
        915                 920                 925             


Gly Leu Thr Ile Lys Pro Ser Ile Leu Gly Phe Asp Thr Pro His Tyr 
    930                 935                 940                 


Trp Leu Cys Asp Asn Arg Leu Leu Cys Leu Gln Asp Pro Asn Asn Lys 
945                 950                 955                 960 


Ser Asn Trp Asn Val Phe Arg Glu Cys Trp Lys Gln Gly Gln Pro Val 
                965                 970                 975     


Met Val Ser Gly Val His His Lys Leu Asn Ser Glu Leu Trp Lys Pro 
            980                 985                 990         


Glu Ser Phe Arg Lys Glu Phe Gly  Glu Gln Glu Val Asp  Leu Val Asn 
        995                 1000                 1005             


Cys Arg  Thr Asn Glu Ile Ile  Thr Gly Ala Thr Val  Gly Asp Phe 
    1010                 1015                 1020             


Trp Asp  Gly Phe Glu Asp Val  Pro Asn Arg Leu Lys  Asn Glu Lys 
    1025                 1030                 1035             


Glu Pro  Met Val Leu Lys Leu  Lys Asp Trp Pro Pro  Gly Glu Asp 
    1040                 1045                 1050             


Phe Arg  Asp Met Met Pro Ser  Arg Phe Asp Asp Leu  Met Ala Asn 
    1055                 1060                 1065             


Ile Pro  Leu Pro Glu Tyr Thr  Arg Arg Asp Gly Lys  Leu Asn Leu 
    1070                 1075                 1080             


Ala Ser  Arg Leu Pro Asn Tyr  Phe Val Arg Pro Asp  Leu Gly Pro 
    1085                 1090                 1095             


Lys Met  Tyr Asn Ala Tyr Gly  Leu Ile Thr Pro Glu  Asp Arg Lys 
    1100                 1105                 1110             


Tyr Gly  Thr Thr Asn Leu His  Leu Asp Val Ser Asp  Ala Ala Asn 
    1115                 1120                 1125             


Val Met  Val Tyr Val Gly Ile  Pro Lys Gly Gln Cys  Glu Gln Glu 
    1130                 1135                 1140             


Glu Glu  Val Leu Lys Thr Ile  Gln Asp Gly Asp Ser  Asp Glu Leu 
    1145                 1150                 1155             


Thr Ile  Lys Arg Phe Ile Glu  Gly Lys Glu Lys Pro  Gly Ala Leu 
    1160                 1165                 1170             


Trp His  Ile Tyr Ala Ala Lys  Asp Thr Glu Lys Ile  Arg Glu Phe 
    1175                 1180                 1185             


Leu Lys  Lys Val Ser Glu Glu  Gln Gly Gln Glu Asn  Pro Ala Asp 
    1190                 1195                 1200             


His Asp  Pro Ile His Asp Gln  Ser Trp Tyr Leu Asp  Arg Ser Leu 
    1205                 1210                 1215             


Arg Lys  Arg Leu His Gln Glu  Tyr Gly Val Gln Gly  Trp Ala Ile 
    1220                 1225                 1230             


Val Gln  Phe Leu Gly Asp Val  Val Phe Ile Pro Ala  Gly Ala Pro 
    1235                 1240                 1245             


His Gln  Val His Asn Leu Tyr  Ser Cys Ile Lys Val  Ala Glu Asp 
    1250                 1255                 1260             


Phe Val  Ser Pro Glu His Val  Lys His Cys Phe Trp  Leu Thr Gln 
    1265                 1270                 1275             


Glu Phe  Arg Tyr Leu Ser Gln  Thr His Thr Asn His  Glu Asp Lys 
    1280                 1285                 1290             


Leu Gln  Val Lys Asn Val Ile  Tyr His Ala Val Lys  Asp Ala Val 
    1295                 1300                 1305             


Ala Met  Leu Lys Ala Ser Glu  Ser Ser Phe Gly Lys  Pro 
    1310                 1315                 1320     


<210>  7787
<211>  7860
<212>  DNA
<213>  Homosapiens

<400>  7787
agcggctccg aggggggcgg gtccgggagg ctgtgcgtgt cttgtgagag ctcttgaacc     60

aagtcagcgc tggagtcggc taggcggctg gaaacggcgg ctgccgccgg tgactcaggg    120

aggcgggagg cgggggagga gctcttcctg caggcgtgga aaccatggtg ctcacgctcg    180

gagaaagttg gccggtattg gtggggagga ggtttctcag tctgtccgca gccgacggca    240

gcgatggcag ccacgacagc tgggacgtgg agcgcgtcgc cgagtggccc tggctctccg    300

ggaccattcg agctgtttcc cacaccgacg ttaccaagaa ggatctgaag gtgtgtgtgg    360

aatttgatgg ggaatcttgg aggaaaagaa gatggataga agtctacagc cttctaagga    420

gagcattttt agtagaacat aatttggttt tagctgaacg aaagtcacct gaaatttctg    480

aacgaattgt acagtggcct gcaataacgt acaaacctct gttggacaaa gctggtttgg    540

gatccataac ttctgttcgc tttctgggag atcaacaaag agtatttctt tctaaagacc    600

ttttgaagcc tatacaggat gtaaacagtc ttcgactttc tcttacggat aatcagattg    660

tcagtaaaga atttcaagct ttgattgtga agcatttaga tgaaagccat cttttaaaag    720

gtgacaaaaa cttagttggt tcagaagtaa aaatttatag cttggaccca tctactcagt    780

ggttttcagc aaccgttata aatggaaacc cagcatcaaa aactcttcaa gtcaactgtg    840

aggagattcc agcactgaaa attgttgatc cgtcactgat tcatgttgaa gttgtacacg    900

ataaccttgt gacatgtggt aattctgcaa gaattggagc tgtaaaacgc aagtcttctg    960

agaataatgg aaccctggtt tccaaacaag caaaatcttg ctctgaggcc tctcccagta   1020

tgtgtcctgt gcagtctgta cctacaacag tttttaagga gatactgctt ggctgtactg   1080

cggcaactcc acctagtaag gacccaagac agcaaagtac tccccaggct gccaactctc   1140

cacctaacct tggagcaaaa attcctcaag gatgtcataa acaaagttta ccagaggaaa   1200

tttcttcctg tctaaataca aagtctgaag ctctgagaac aaaaccagat gtctgcaaag   1260

cagggttgct ctcaaagtcc tctcagattg gaactggaga cttgaaaatt ctgactgagc   1320

caaaaggcag ctgtactcag cctaagacaa acactgatca ggaaaacaga ttggagtctg   1380

ttccacaagc attgactggc cttcctaagg agtgcttacc tacaaaggct tcttctaagg   1440

cagaattgga aattgccaat cctcctgaac tgcagaagca cctagaacat gcaccttccc   1500

catcggatgt ttcaaatgca ccagaagtga aagcaggtgt caatagtgat agccctaata   1560

actgttcagg aaaaaaggta gaaccttcag ctttagcttg ccgatcacag aatttaaagg   1620

aatcttcagt aaaagtagat aatgaaagct gttgttcaag aagcaacaat aaaatccaga   1680

atgccccatc caggaagtcg gttttgacag acccagctaa actcaaaaag ctgcaacaga   1740

gtggcgaggc cttcgtacag gatgattctt gtgtgaacat cgtggcacag ttgcctaaat   1800

gccgagagtg tcgcttggac agtctccgca aggataagga gcaacagaag gactcacctg   1860

tgttttgccg cttctttcac ttcaggaggt tacaattcaa caaacatggt gtgttgcggg   1920

tagaaggctt cttaacacca aacaagtatg acaatgaagc aattggcttg tggttacctt   1980

taaccaaaaa cgttgtgggg attgatttgg acacagcaaa gtacatcttg gccaacattg   2040

gagaccactt ctgtcaaatg gtgatttctg aaaaggaagc tatgtcaact attgagccac   2100

acagacaggt tgcttggaag cgagctgtca aaggtgttcg agaaatgtgt gatgtgtgcg   2160

acaccaccat cttcaacctg cactgggtgt gtcctcggtg tgggtttgga gtatgtgtgg   2220

actgctaccg gatgaagaga aagaattgcc aacagggtga gaaccgattt gattctcctc   2280

cagcccctct acacagttaa atcaagtgtt tttgttgatt tgtgtttggc gggtttcttg   2340

aagcatgtgg agacagagtc tgtaaagaac agttactaca aatcagttat ttgcaggtgc   2400

tgcttacaag actttctctt ggctaaaatg tgtgaagagt cagatacatg aaccagagaa   2460

cttaatgccc acacagatca ttcctggaaa aggtatttca tgtgctgcag tgattttctt   2520

tccccttgtc ttggttaact catgggagct ggtagttttg ttttccttta ttactcgtta   2580

agtttatttt agtgtgtatt gtaagttgtc cagaaatata ttagataatt cctccaacac   2640

ttttcgagtc aagttttgtg ggatagtttt gtagtagaaa agaaaatgca ttttggggaa   2700

ggcctctgga gcaggatgaa aaggagggag tgggaaaagt aatcctgtgg ggaatgccag   2760

cttctgctct gtaatgttga ggttgaaagt tcctaatatc cttgttcaga tgtttgcctc   2820

tgccctttct ttagcactct atgatgttgg agacattgtt cattctgtaa gagcgaaatg   2880

gggaataaag gcaaactgcc cttgttcaaa caggcaattc aaactctttt caaagccagc   2940

ctcaaaggaa gacctaaaac aggtatttac tgcttatgtt aaattcaaca tctcttgtaa   3000

ttgtcatttg tctgtttttc aaataaccca aggatttcta tcagtgcatt tgaaaggaac   3060

ctggggatag ctatcaagtg gaaagagaga gagaaagaat tcatacagtt catgtgacag   3120

ttcagagacc cgttctgact tttcacatta ctttcgtaga ctctactgtg gcctcttgta   3180

gtaggtttta catttttgtt tcttgaagaa gcacaaagtt ctaaagtagt ctacctaata   3240

agtagctgtc gaatttgtaa agggtttaaa aaaatttttt gtgtattttg cagaattaaa   3300

attattaaga taagctttaa catttttaaa attactaaat atattttgcc tgtgtttatg   3360

cagagttgaa ggaaatgatg aaatgaacct ttagttgccc atcacacaat gtaaaaaatg   3420

ttaattttct cagtcctcat atgtctctcc ttggtggcat ccctctcctc cccaccatca   3480

catgtacgtc ttgctgtccc ttctccccct cgttccagta atcagtatgc cgcattgtgt   3540

ttaataatca gaaatttaca tttctataaa gctgtggtgt cataaggcag gatgggagag   3600

cagaagactt gtaatatttg gagtcagaac tgaatttgag ttcttttcct tccacgtgct   3660

agttgtgtta ctttggctga agtgagctgg tttctatgtg cttcagcttc ctcatcagta   3720

atatagaaat aagaagcaat attgatgatt gggcatcaca gaattacatc acatgtaaag   3780

agagggcctg gaccacaaca ggggtttgaa tatttttttt cctccttctt atgtatgtat   3840

aaactcactc ttgccagttt ttaaaattat tttcttctac agcagtcatc ttagatttaa   3900

tttatgggtt cttttaagag ctcatcacat ttttaaagct aagtcaaaat agcattttct   3960

ctttctctgc atcccatttc cttctgaaat caccgcttta cctttcctgc ctgcgtcatt   4020

tattcgtttt taaccatgtt ttctgtgcct atcctgaatt ctgggatgag ttcatagggg   4080

agacaggcac aaactggtca ttttaaacca gcatggtaca tagagtaata gggatatgta   4140

ccagcagggg ctggtgaaag ggtgcggggg gtaatacctt gctgtgttta agttgctgac   4200

atctctccta ccttttagtt attctctact agtgcgggat tactgcagct gtggggatac   4260

ccagggctaa ctattaggtg gttttgttct ggatatttat cttacttgtt ggtcggctat   4320

taggagagaa gaaaagaaaa ggaagctgtc attcttcagc ttatgtaaaa tcgtccttta   4380

atgcttaaca cagacttctt tagctggaga aaaaccgact cttggtgcag tgctccagca   4440

gaatccctca gtgttggagc cagcagctgt gggtggggaa gcagcctcca agccagccgg   4500

cagcatgaag cctgcctgtc cagccagcac atctcctcta aactggctgg ccgacctaac   4560

cagcgggaat gtcaacaagg aaaacaagga aaaacaacca acaatgccaa ttttaaagaa   4620

tgaaatcaaa tgccttccac ccctcccacc tttaagcaaa tccagcacag tcctccatac   4680

gtttaacagc acaattttga cacccgtaag caacaacaat tctggtttcc tccggaatct   4740

cttgaattct tctacaggaa agacagaaaa tggactcaag aatacaccaa aaatccttga   4800

tgacatcttt gcctctttgg tgcaaaataa gacgacttct gatttatcta agaggcctca   4860

aggactaacc atcaagccca gcattctggg ctttgacact cctcactatt ggctttgtga   4920

taatcgcttg ctgtgcttgc aagaccccaa caataagagc aactggaatg tgtttaggga   4980

gtgctggaaa caagggcagc cagtgatggt gtctggagtg catcataaat tgaactctga   5040

actttggaaa cctgaatcct tcaggaaaga gtttggtgag caggaagtag acctagttaa   5100

ttgtaggacc aatgaaatca tcacaggagc cacagtagga gacttctggg atggatttga   5160

agatgttcca aatcgtttga aaaatgaaaa agaaccaatg gtgttgaaac ttaaggactg   5220

gccaccagga gaagatttta gagatatgat gccttccagg tttgatgatc tgatggccaa   5280

cattccactg cccgagtaca caaggcgaga tggcaaactg aatttggcct ctaggctgcc   5340

aaactacttt gttcggccag atctgggccc caagatgtat aatgcttatg gattaatcac   5400

tcctgaagat cggaaatatg gaacaacaaa tcttcactta gatgtatctg atgcagctaa   5460

tgtcatggtc tatgtgggaa ttcccaaagg acagtgtgag caagaagaag aagtccttaa   5520

gaccatccaa gatggagatt ctgacgaact cacaataaag cgatttattg aaggaaaaga   5580

gaagccagga gcactgtggc acatatatgc tgcaaaggac acggagaaga taagggaatt   5640

tcttaaaaag gtatcagaag agcaaggtca agaaaaccca gcagaccacg atcctattca   5700

tgatcaaagc tggtatttag accgatcatt aagaaaacgt cttcatcaag agtatggagt   5760

tcaaggctgg gctattgtac agtttcttgg ggatgtggtg tttatcccgg caggagctcc   5820

acatcaggtt cataacttat atagctgcat caaagtggct gaagattttg tttctccaga   5880

gcatgttaaa cactgcttct ggcttactca ggaattccga tatctgtcac agactcatac   5940

caatcacgaa gataaattac aggtgaagaa tgttatctac catgcagtga aagatgcagt   6000

tgctatgctg aaagccagtg aatccagttt tggcaaacct taatctccct gcacattgga   6060

aatgaattac aggcagctgt tcaaactctt caggcaggat tcctgtggac tttgagattc   6120

atgttacctc atcttctttt ttaaactgta cccaacttgt gagggtactc tgtctaatgt   6180

atatttctag tgtttacaga cagtaaatgt gtatatgtag taactattta cagaacatgc   6240

atccttaaac tgtgacttct cacctagtgc agaactttta ccaggctgta aaagcaaaac   6300

ctcgtatcag ctctggaaca atacctgcag ttattcttca gctgtttgga caacttagat   6360

tgggtttata actattagga atcactgcac agtttatttg ggttgtgttt tgtgtctgag   6420

tcccctccct catcccttag ggtccagaag agcaatggag gaagtgacag ctaatgttgc   6480

agttcttatt gtatggcata ggactggcat tatatagcag aaatcaacta ctgtacaatt   6540

tcttggggtt aaccatcttt agttaaatgg aattttaatt taaatgacgc tttgctaatt   6600

ttaagtgtta agcattttgc attaaaatat tcatataata ttttggctca gtttattggc   6660

attatcctct cattgtggtt tcaacacaac tttcttcaaa tgcaggtgta atggattgct   6720

ccaagaactc ttcttaaaag caaagaaatc agatgctata gtgattttct tagtgattat   6780

tacaaagcta acatggaaat ttctgctcag ccaggtagaa accctgtcac actttgtcaa   6840

ggaaacacca ccaattaatt aaatttagaa acaggaatta accaagaaac caaatagtgc   6900

caggctaaat ggttctaaaa aggtaagtaa tgaaacactt tgttttatgg cccttcataa   6960

tgttaagttt atgaaggaaa atgaaattat aagttctagg acagtactac ctaaaatatt   7020

catctctgtg aaggaaaaaa attcacaaag aagcgccttt ctttagccca ctgattctcc   7080

taggccactc tttcatttaa tttctttaaa aaaaggaatt aaacatagaa atcagatagt   7140

acatagacaa agcctagaac ctgagtttta atttgtgagc tgagtaggag gccagaggat   7200

ccgtattaaa tttcagaacc cattgtcaaa tctaaggtca aagatttgct ctaatgtttt   7260

cttctaggag ttttaaaatt ttagccctta aattaagtct ttgacctatt ttgagttaat   7320

tattaaatat ggtgtaaaga ttcaacttca tttttttgaa tatggatatc cagttttccc   7380

agcaacattt gtcgtcaaac actgttcttt cccccattga atggtcttgg cactctagtt   7440

aaaaatcaat tgatcgtaga tgggaaagca tattactagg ctctcatatt ccactggtct   7500

gtgtatctgt ctttatgcca gtactgcact gttttgattt ctgctacttt gtagtaagtt   7560

ttaaaatcaa caactgtgag ttctccaact ctggtcttct ttttcatgat tgttttaatc   7620

agggtcactg gaaattccgt acgaattttg ggataggttt ttttatttct gcaaaaaaca   7680

ccatctgggt attaatagag attgcattga acctgtatgt tcctttgggt gtcatcttaa   7740

caatctaatt cttgcaatcc atgagcatgg gatgttgtgt ttccatttat tggtgtcttc   7800

tttaatgtct ttcagcaatg ttttgtagtt ttcagttgca tgagttttgt accttcatgg   7860


<210>  7788
<211>  711
<212>  PRT
<213>  Homosapiens

<400>  7788

Met Val Leu Thr Leu Gly Glu Ser Trp Pro Val Leu Val Gly Arg Arg 
1               5                   10                  15      


Phe Leu Ser Leu Ser Ala Ala Asp Gly Ser Asp Gly Ser His Asp Ser 
            20                  25                  30          


Trp Asp Val Glu Arg Val Ala Glu Trp Pro Trp Leu Ser Gly Thr Ile 
        35                  40                  45              


Arg Ala Val Ser His Thr Asp Val Thr Lys Lys Asp Leu Lys Val Cys 
    50                  55                  60                  


Val Glu Phe Asp Gly Glu Ser Trp Arg Lys Arg Arg Trp Ile Glu Val 
65                  70                  75                  80  


Tyr Ser Leu Leu Arg Arg Ala Phe Leu Val Glu His Asn Leu Val Leu 
                85                  90                  95      


Ala Glu Arg Lys Ser Pro Glu Ile Ser Glu Arg Ile Val Gln Trp Pro 
            100                 105                 110         


Ala Ile Thr Tyr Lys Pro Leu Leu Asp Lys Ala Gly Leu Gly Ser Ile 
        115                 120                 125             


Thr Ser Val Arg Phe Leu Gly Asp Gln Gln Arg Val Phe Leu Ser Lys 
    130                 135                 140                 


Asp Leu Leu Lys Pro Ile Gln Asp Val Asn Ser Leu Arg Leu Ser Leu 
145                 150                 155                 160 


Thr Asp Asn Gln Ile Val Ser Lys Glu Phe Gln Ala Leu Ile Val Lys 
                165                 170                 175     


His Leu Asp Glu Ser His Leu Leu Lys Gly Asp Lys Asn Leu Val Gly 
            180                 185                 190         


Ser Glu Val Lys Ile Tyr Ser Leu Asp Pro Ser Thr Gln Trp Phe Ser 
        195                 200                 205             


Ala Thr Val Ile Asn Gly Asn Pro Ala Ser Lys Thr Leu Gln Val Asn 
    210                 215                 220                 


Cys Glu Glu Ile Pro Ala Leu Lys Ile Val Asp Pro Ser Leu Ile His 
225                 230                 235                 240 


Val Glu Val Val His Asp Asn Leu Val Thr Cys Gly Asn Ser Ala Arg 
                245                 250                 255     


Ile Gly Ala Val Lys Arg Lys Ser Ser Glu Asn Asn Gly Thr Leu Val 
            260                 265                 270         


Ser Lys Gln Ala Lys Ser Cys Ser Glu Ala Ser Pro Ser Met Cys Pro 
        275                 280                 285             


Val Gln Ser Val Pro Thr Thr Val Phe Lys Glu Ile Leu Leu Gly Cys 
    290                 295                 300                 


Thr Ala Ala Thr Pro Pro Ser Lys Asp Pro Arg Gln Gln Ser Thr Pro 
305                 310                 315                 320 


Gln Ala Ala Asn Ser Pro Pro Asn Leu Gly Ala Lys Ile Pro Gln Gly 
                325                 330                 335     


Cys His Lys Gln Ser Leu Pro Glu Glu Ile Ser Ser Cys Leu Asn Thr 
            340                 345                 350         


Lys Ser Glu Ala Leu Arg Thr Lys Pro Asp Val Cys Lys Ala Gly Leu 
        355                 360                 365             


Leu Ser Lys Ser Ser Gln Ile Gly Thr Gly Asp Leu Lys Ile Leu Thr 
    370                 375                 380                 


Glu Pro Lys Gly Ser Cys Thr Gln Pro Lys Thr Asn Thr Asp Gln Glu 
385                 390                 395                 400 


Asn Arg Leu Glu Ser Val Pro Gln Ala Leu Thr Gly Leu Pro Lys Glu 
                405                 410                 415     


Cys Leu Pro Thr Lys Ala Ser Ser Lys Ala Glu Leu Glu Ile Ala Asn 
            420                 425                 430         


Pro Pro Glu Leu Gln Lys His Leu Glu His Ala Pro Ser Pro Ser Asp 
        435                 440                 445             


Val Ser Asn Ala Pro Glu Val Lys Ala Gly Val Asn Ser Asp Ser Pro 
    450                 455                 460                 


Asn Asn Cys Ser Gly Lys Lys Val Glu Pro Ser Ala Leu Ala Cys Arg 
465                 470                 475                 480 


Ser Gln Asn Leu Lys Glu Ser Ser Val Lys Val Asp Asn Glu Ser Cys 
                485                 490                 495     


Cys Ser Arg Ser Asn Asn Lys Ile Gln Asn Ala Pro Ser Arg Lys Ser 
            500                 505                 510         


Val Leu Thr Asp Pro Ala Lys Leu Lys Lys Leu Gln Gln Ser Gly Glu 
        515                 520                 525             


Ala Phe Val Gln Asp Asp Ser Cys Val Asn Ile Val Ala Gln Leu Pro 
    530                 535                 540                 


Lys Cys Arg Glu Cys Arg Leu Asp Ser Leu Arg Lys Asp Lys Glu Gln 
545                 550                 555                 560 


Gln Lys Asp Ser Pro Val Phe Cys Arg Phe Phe His Phe Arg Arg Leu 
                565                 570                 575     


Gln Phe Asn Lys His Gly Val Leu Arg Val Glu Gly Phe Leu Thr Pro 
            580                 585                 590         


Asn Lys Tyr Asp Asn Glu Ala Ile Gly Leu Trp Leu Pro Leu Thr Lys 
        595                 600                 605             


Asn Val Val Gly Ile Asp Leu Asp Thr Ala Lys Tyr Ile Leu Ala Asn 
    610                 615                 620                 


Ile Gly Asp His Phe Cys Gln Met Val Ile Ser Glu Lys Glu Ala Met 
625                 630                 635                 640 


Ser Thr Ile Glu Pro His Arg Gln Val Ala Trp Lys Arg Ala Val Lys 
                645                 650                 655     


Gly Val Arg Glu Met Cys Asp Val Cys Asp Thr Thr Ile Phe Asn Leu 
            660                 665                 670         


His Trp Val Cys Pro Arg Cys Gly Phe Gly Val Cys Val Asp Cys Tyr 
        675                 680                 685             


Arg Met Lys Arg Lys Asn Cys Gln Gln Gly Glu Asn Arg Phe Asp Ser 
    690                 695                 700                 


Pro Pro Ala Pro Leu His Ser 
705                 710     


<210>  7789
<211>  4638
<212>  DNA
<213>  Homosapiens

<400>  7789
ctcggctgcg gggagagggg agagaaaggg aggagctctt cctgcaggcg tggaaaccat     60

ggtgctcacg ctcggagaaa gttggccggt attggtgggg aggaggtttc tcagtctgtc    120

cgcagccgac ggcagcgatg gcagccacga cagctgggac gtggagcgcg tcgccgagtg    180

gccctggctc tccgggacca ttcgagctgt ttcccacacc gacgttacca agaaggatct    240

gaaggtgtgt gtggaatttg atggggaatc ttggaggaaa agaagatgga tagaagtcta    300

cagccttcta aggagagcat ttttagtaga acataatttg gttttagctg aacgaaagtc    360

acctgaaatt tctgaacgaa ttgtacagtg gcctgcaata acgtacaaac ctctgttgga    420

caaagctggt ttgggatcca taacttctgt tcgctttctg ggagatcaac aaagagtatt    480

tctttctaaa gaccttttga agcctataca ggatgtaaac agtcttcgac tttctcttac    540

ggataatcag attgtcagta aagaatttca agctttgatt gtgaagcatt tagatgaaag    600

ccatctttta aaaggtgaca aaaacttagt tggttcagaa gtaaaaattt atagcttgga    660

cccatctact cagtggtttt cagcaaccgt tataaatgga aacccagcat caaaaactct    720

tcaagtcaac tgtgaggaga ttccagcact gaaaattgtt gatccgtcac tgattcatgt    780

tgaagttgta cacgataacc ttgtgacatg tggtaattct gcaagaattg gagctgtaaa    840

acgcaagtct tctgagaata atggaaccct ggtttccaaa caagcaaaat cttgctctga    900

ggcctctccc agtatgtgtc ctgtgcagtc tgtacctaca acagttttta aggagatact    960

gcttggctgt actgcggcaa ctccacctag taaggaccca agacagcaaa gtactcccca   1020

ggctgccaac tctccaccta accttggagc aaaaattcct caaggatgtc ataaacaaag   1080

tttaccagag gaaatttctt cctgtctaaa tacaaagtct gaagctctga gaacaaaacc   1140

agatgtctgc aaagcagggt tgctctcaaa gtcctctcag attggaactg gagacttgaa   1200

aattctgact gagccaaaag gcagctgtac tcagcctaag acaaacactg atcaggaaaa   1260

cagattggag tctgttccac aagcattgac tggccttcct aaggagtgct tacctacaaa   1320

ggcttcttct aaggcagaat tggaaattgc caatcctcct gaactgcaga agcacctaga   1380

acatgcacct tccccatcgg atgtttcaaa tgcaccagaa gtgaaagcag gtgtcaatag   1440

tgatagccct aataactgtt caggaaaaaa ggtagaacct tcagctttag cttgccgatc   1500

acagaattta aaggaatctt cagtaaaagt agataatgaa agctgttgtt caagaagcaa   1560

caataaaatc cagaatgccc catccaggaa gtcggttttg acagacccag ctaaactcaa   1620

aaagctgcaa cagagtggcg aggccttcgt acaggatgat tcttgtgtga acatcgtggc   1680

acagttgcct aaatgccgag agtgtcgctt ggacagtctc cgcaaggata aggagcaaca   1740

gaaggactca cctgtgtttt gccgcttctt tcacttcagg aggttacaat tcaacaaaca   1800

tggtgtgttg cgggtagaag gcttcttaac accaaacaag tatgacaatg aagcaattgg   1860

cttgtggtta cctttaacca aaaacgttgt ggggattgat ttggacacag caaagtacat   1920

cttggccaac attggagacc acttctgtca aatggtgatt tctgaaaagg aagctatgtc   1980

aactattgag ccacacagac aggttgcttg gaagcgagct gtcaaaggtg ttcgagaaat   2040

gtgtgatgtg tgcgacacca ccatcttcaa cctgcactgg gtgtgtcctc ggtgtgggtt   2100

tggagtatgt gtggactgct accggatgaa gagaaagaat tgccaacagg gtgctgctta   2160

caagactttc tcttggctaa aatgtgtgaa gagtcagata catgaaccag agaacttaat   2220

gcccacacag atcattcctg gaaaagcact ctatgatgtt ggagacattg ttcattctgt   2280

aagagcgaaa tggggaataa aggcaaactg cccttgttca aacaggcaat tcaaactctt   2340

ttcaaagcca gcctcaaagg aagacctaaa acagacttct ttagctggag aaaaaccgac   2400

tcttggtgca gtgctccagc agaatccctc agtgttggag ccagcagctg tgggtgggga   2460

agcagcctcc aagccagccg gcagcatgaa gcctgcctgt ccagccagca catctcctct   2520

aaactggctg gccgacctaa ccagcgggaa tgtcaacaag gaaaacaagg aaaaacaacc   2580

aacaatgcca attttaaaga atgaaatcaa atgccttcca cccctcccac ctttaagcaa   2640

atccagcaca gtcctccata cgtttaacag cacaattttg acacccgtaa gcaacaacaa   2700

ttctggtttc ctccggaatc tcttgaattc ttctacagga aagacagaaa atggactcaa   2760

gaatacacca aaaatccttg atgacatctt tgcctctttg gtgcaaaata agacgacttc   2820

tgatttatct aagaggcctc aaggactaac catcaagccc agcattctgg gctttgacac   2880

tcctcactat tggctttgtg ataatcgctt gctgtgcttg caagacccca acaataagag   2940

caactggaat gtgtttaggg agtgctggaa acaagggcag ccagtgatgg tgtctggagt   3000

gcatcataaa ttgaactctg aactttggaa acctgaatcc ttcaggaaag agtttggtga   3060

gcaggaagta gacctagtta attgtaggac caatgaaatc atcacaggag ccacagtagg   3120

agacttctgg gatggatttg aagatgttcc aaatcgtttg aaaaatgaaa aagaaccaat   3180

ggtgttgaaa cttaaggact ggccaccagg agaagatttt agagatatga tgccttccag   3240

gtttgatgat ctgatggcca acattccact gcccgagtac acaaggcgag atggcaaact   3300

gaatttggcc tctaggctgc caaactactt tgttcggcca gatctgggcc ccaagatgta   3360

taatgcttat ggattaatca ctcctgaaga tcggaaatat ggaacaacaa atcttcactt   3420

agatgtatct gatgcagcta atgtcatggt ctatgtggga attcccaaag gacagtgtga   3480

gcaagaagaa gaagtcctta agaccatcca agatggagat tctgacgaac tcacaataaa   3540

gcgatttatt gaaggaaaag agaagccagg agcactgtgg cacatatatg ctgcaaagga   3600

cacggagaag ataagggaat ttcttaaaaa ggtatcagaa gagcaaggtc aagaaaaccc   3660

agcagaccac gatcctattc atgatcaaag ctggtattta gaccgatcat taagaaaacg   3720

tcttcatcaa gagtatggag ttcaaggctg ggctattgta cagtttcttg gggatgtggt   3780

gtttatcccg gcaggagctc cacatcaggt tcataactta tatagctgca tcaaagtggc   3840

tgaagatttt gtttctccag agcatgttaa acactgcttc tggcttactc aggaattccg   3900

atatctgtca cagactcata ccaatcacga agataaatta caggtgaaga atgttatcta   3960

ccatgcagtg aaagatgcag ttgctatgct gaaagccagt gaatccagtt ttggcaaacc   4020

ttaatctccc tgcacattgg aaatgaatta caggcagctg ttcaaactct tcaggcagga   4080

ttcctgtgga ctttgagatt catgttacct catcttcttt tttaaactgt acccaacttg   4140

tgagggtact ctgtctaatg tatatttcta gtgtttacag acagtaaatg tgtatatgta   4200

gtaactattt acagaacatg catccttaaa ctgtgacttc tcacctagtg cagaactttt   4260

accaggctgt aaaagcaaaa cctcgtatca gctctggaac aatacctgca gttattcttc   4320

agctgtttgg acaacttaga ttgggtttat aactattagg aatcactgca cagtttattt   4380

gggttgtgtt ttgtgtctga gtcccctccc tcatccctta gggtccagaa gagcaatgga   4440

ggaagtgaca gctaatgttg cagttcttat tgtatggcat aggactggca ttatatagca   4500

gaaatcaact actgtacaat ttcttggggt taaccatctt tagttaaatg gaattttaat   4560

ttaaatgacg ctttgctaat tttaagtgtt aagcattttg cattaaaata ttcatataat   4620

attttggctc agtttatt                                                 4638


<210>  7790
<211>  1321
<212>  PRT
<213>  Homosapiens

<400>  7790

Met Val Leu Thr Leu Gly Glu Ser Trp Pro Val Leu Val Gly Arg Arg 
1               5                   10                  15      


Phe Leu Ser Leu Ser Ala Ala Asp Gly Ser Asp Gly Ser His Asp Ser 
            20                  25                  30          


Trp Asp Val Glu Arg Val Ala Glu Trp Pro Trp Leu Ser Gly Thr Ile 
        35                  40                  45              


Arg Ala Val Ser His Thr Asp Val Thr Lys Lys Asp Leu Lys Val Cys 
    50                  55                  60                  


Val Glu Phe Asp Gly Glu Ser Trp Arg Lys Arg Arg Trp Ile Glu Val 
65                  70                  75                  80  


Tyr Ser Leu Leu Arg Arg Ala Phe Leu Val Glu His Asn Leu Val Leu 
                85                  90                  95      


Ala Glu Arg Lys Ser Pro Glu Ile Ser Glu Arg Ile Val Gln Trp Pro 
            100                 105                 110         


Ala Ile Thr Tyr Lys Pro Leu Leu Asp Lys Ala Gly Leu Gly Ser Ile 
        115                 120                 125             


Thr Ser Val Arg Phe Leu Gly Asp Gln Gln Arg Val Phe Leu Ser Lys 
    130                 135                 140                 


Asp Leu Leu Lys Pro Ile Gln Asp Val Asn Ser Leu Arg Leu Ser Leu 
145                 150                 155                 160 


Thr Asp Asn Gln Ile Val Ser Lys Glu Phe Gln Ala Leu Ile Val Lys 
                165                 170                 175     


His Leu Asp Glu Ser His Leu Leu Lys Gly Asp Lys Asn Leu Val Gly 
            180                 185                 190         


Ser Glu Val Lys Ile Tyr Ser Leu Asp Pro Ser Thr Gln Trp Phe Ser 
        195                 200                 205             


Ala Thr Val Ile Asn Gly Asn Pro Ala Ser Lys Thr Leu Gln Val Asn 
    210                 215                 220                 


Cys Glu Glu Ile Pro Ala Leu Lys Ile Val Asp Pro Ser Leu Ile His 
225                 230                 235                 240 


Val Glu Val Val His Asp Asn Leu Val Thr Cys Gly Asn Ser Ala Arg 
                245                 250                 255     


Ile Gly Ala Val Lys Arg Lys Ser Ser Glu Asn Asn Gly Thr Leu Val 
            260                 265                 270         


Ser Lys Gln Ala Lys Ser Cys Ser Glu Ala Ser Pro Ser Met Cys Pro 
        275                 280                 285             


Val Gln Ser Val Pro Thr Thr Val Phe Lys Glu Ile Leu Leu Gly Cys 
    290                 295                 300                 


Thr Ala Ala Thr Pro Pro Ser Lys Asp Pro Arg Gln Gln Ser Thr Pro 
305                 310                 315                 320 


Gln Ala Ala Asn Ser Pro Pro Asn Leu Gly Ala Lys Ile Pro Gln Gly 
                325                 330                 335     


Cys His Lys Gln Ser Leu Pro Glu Glu Ile Ser Ser Cys Leu Asn Thr 
            340                 345                 350         


Lys Ser Glu Ala Leu Arg Thr Lys Pro Asp Val Cys Lys Ala Gly Leu 
        355                 360                 365             


Leu Ser Lys Ser Ser Gln Ile Gly Thr Gly Asp Leu Lys Ile Leu Thr 
    370                 375                 380                 


Glu Pro Lys Gly Ser Cys Thr Gln Pro Lys Thr Asn Thr Asp Gln Glu 
385                 390                 395                 400 


Asn Arg Leu Glu Ser Val Pro Gln Ala Leu Thr Gly Leu Pro Lys Glu 
                405                 410                 415     


Cys Leu Pro Thr Lys Ala Ser Ser Lys Ala Glu Leu Glu Ile Ala Asn 
            420                 425                 430         


Pro Pro Glu Leu Gln Lys His Leu Glu His Ala Pro Ser Pro Ser Asp 
        435                 440                 445             


Val Ser Asn Ala Pro Glu Val Lys Ala Gly Val Asn Ser Asp Ser Pro 
    450                 455                 460                 


Asn Asn Cys Ser Gly Lys Lys Val Glu Pro Ser Ala Leu Ala Cys Arg 
465                 470                 475                 480 


Ser Gln Asn Leu Lys Glu Ser Ser Val Lys Val Asp Asn Glu Ser Cys 
                485                 490                 495     


Cys Ser Arg Ser Asn Asn Lys Ile Gln Asn Ala Pro Ser Arg Lys Ser 
            500                 505                 510         


Val Leu Thr Asp Pro Ala Lys Leu Lys Lys Leu Gln Gln Ser Gly Glu 
        515                 520                 525             


Ala Phe Val Gln Asp Asp Ser Cys Val Asn Ile Val Ala Gln Leu Pro 
    530                 535                 540                 


Lys Cys Arg Glu Cys Arg Leu Asp Ser Leu Arg Lys Asp Lys Glu Gln 
545                 550                 555                 560 


Gln Lys Asp Ser Pro Val Phe Cys Arg Phe Phe His Phe Arg Arg Leu 
                565                 570                 575     


Gln Phe Asn Lys His Gly Val Leu Arg Val Glu Gly Phe Leu Thr Pro 
            580                 585                 590         


Asn Lys Tyr Asp Asn Glu Ala Ile Gly Leu Trp Leu Pro Leu Thr Lys 
        595                 600                 605             


Asn Val Val Gly Ile Asp Leu Asp Thr Ala Lys Tyr Ile Leu Ala Asn 
    610                 615                 620                 


Ile Gly Asp His Phe Cys Gln Met Val Ile Ser Glu Lys Glu Ala Met 
625                 630                 635                 640 


Ser Thr Ile Glu Pro His Arg Gln Val Ala Trp Lys Arg Ala Val Lys 
                645                 650                 655     


Gly Val Arg Glu Met Cys Asp Val Cys Asp Thr Thr Ile Phe Asn Leu 
            660                 665                 670         


His Trp Val Cys Pro Arg Cys Gly Phe Gly Val Cys Val Asp Cys Tyr 
        675                 680                 685             


Arg Met Lys Arg Lys Asn Cys Gln Gln Gly Ala Ala Tyr Lys Thr Phe 
    690                 695                 700                 


Ser Trp Leu Lys Cys Val Lys Ser Gln Ile His Glu Pro Glu Asn Leu 
705                 710                 715                 720 


Met Pro Thr Gln Ile Ile Pro Gly Lys Ala Leu Tyr Asp Val Gly Asp 
                725                 730                 735     


Ile Val His Ser Val Arg Ala Lys Trp Gly Ile Lys Ala Asn Cys Pro 
            740                 745                 750         


Cys Ser Asn Arg Gln Phe Lys Leu Phe Ser Lys Pro Ala Ser Lys Glu 
        755                 760                 765             


Asp Leu Lys Gln Thr Ser Leu Ala Gly Glu Lys Pro Thr Leu Gly Ala 
    770                 775                 780                 


Val Leu Gln Gln Asn Pro Ser Val Leu Glu Pro Ala Ala Val Gly Gly 
785                 790                 795                 800 


Glu Ala Ala Ser Lys Pro Ala Gly Ser Met Lys Pro Ala Cys Pro Ala 
                805                 810                 815     


Ser Thr Ser Pro Leu Asn Trp Leu Ala Asp Leu Thr Ser Gly Asn Val 
            820                 825                 830         


Asn Lys Glu Asn Lys Glu Lys Gln Pro Thr Met Pro Ile Leu Lys Asn 
        835                 840                 845             


Glu Ile Lys Cys Leu Pro Pro Leu Pro Pro Leu Ser Lys Ser Ser Thr 
    850                 855                 860                 


Val Leu His Thr Phe Asn Ser Thr Ile Leu Thr Pro Val Ser Asn Asn 
865                 870                 875                 880 


Asn Ser Gly Phe Leu Arg Asn Leu Leu Asn Ser Ser Thr Gly Lys Thr 
                885                 890                 895     


Glu Asn Gly Leu Lys Asn Thr Pro Lys Ile Leu Asp Asp Ile Phe Ala 
            900                 905                 910         


Ser Leu Val Gln Asn Lys Thr Thr Ser Asp Leu Ser Lys Arg Pro Gln 
        915                 920                 925             


Gly Leu Thr Ile Lys Pro Ser Ile Leu Gly Phe Asp Thr Pro His Tyr 
    930                 935                 940                 


Trp Leu Cys Asp Asn Arg Leu Leu Cys Leu Gln Asp Pro Asn Asn Lys 
945                 950                 955                 960 


Ser Asn Trp Asn Val Phe Arg Glu Cys Trp Lys Gln Gly Gln Pro Val 
                965                 970                 975     


Met Val Ser Gly Val His His Lys Leu Asn Ser Glu Leu Trp Lys Pro 
            980                 985                 990         


Glu Ser Phe Arg Lys Glu Phe Gly  Glu Gln Glu Val Asp  Leu Val Asn 
        995                 1000                 1005             


Cys Arg  Thr Asn Glu Ile Ile  Thr Gly Ala Thr Val  Gly Asp Phe 
    1010                 1015                 1020             


Trp Asp  Gly Phe Glu Asp Val  Pro Asn Arg Leu Lys  Asn Glu Lys 
    1025                 1030                 1035             


Glu Pro  Met Val Leu Lys Leu  Lys Asp Trp Pro Pro  Gly Glu Asp 
    1040                 1045                 1050             


Phe Arg  Asp Met Met Pro Ser  Arg Phe Asp Asp Leu  Met Ala Asn 
    1055                 1060                 1065             


Ile Pro  Leu Pro Glu Tyr Thr  Arg Arg Asp Gly Lys  Leu Asn Leu 
    1070                 1075                 1080             


Ala Ser  Arg Leu Pro Asn Tyr  Phe Val Arg Pro Asp  Leu Gly Pro 
    1085                 1090                 1095             


Lys Met  Tyr Asn Ala Tyr Gly  Leu Ile Thr Pro Glu  Asp Arg Lys 
    1100                 1105                 1110             


Tyr Gly  Thr Thr Asn Leu His  Leu Asp Val Ser Asp  Ala Ala Asn 
    1115                 1120                 1125             


Val Met  Val Tyr Val Gly Ile  Pro Lys Gly Gln Cys  Glu Gln Glu 
    1130                 1135                 1140             


Glu Glu  Val Leu Lys Thr Ile  Gln Asp Gly Asp Ser  Asp Glu Leu 
    1145                 1150                 1155             


Thr Ile  Lys Arg Phe Ile Glu  Gly Lys Glu Lys Pro  Gly Ala Leu 
    1160                 1165                 1170             


Trp His  Ile Tyr Ala Ala Lys  Asp Thr Glu Lys Ile  Arg Glu Phe 
    1175                 1180                 1185             


Leu Lys  Lys Val Ser Glu Glu  Gln Gly Gln Glu Asn  Pro Ala Asp 
    1190                 1195                 1200             


His Asp  Pro Ile His Asp Gln  Ser Trp Tyr Leu Asp  Arg Ser Leu 
    1205                 1210                 1215             


Arg Lys  Arg Leu His Gln Glu  Tyr Gly Val Gln Gly  Trp Ala Ile 
    1220                 1225                 1230             


Val Gln  Phe Leu Gly Asp Val  Val Phe Ile Pro Ala  Gly Ala Pro 
    1235                 1240                 1245             


His Gln  Val His Asn Leu Tyr  Ser Cys Ile Lys Val  Ala Glu Asp 
    1250                 1255                 1260             


Phe Val  Ser Pro Glu His Val  Lys His Cys Phe Trp  Leu Thr Gln 
    1265                 1270                 1275             


Glu Phe  Arg Tyr Leu Ser Gln  Thr His Thr Asn His  Glu Asp Lys 
    1280                 1285                 1290             


Leu Gln  Val Lys Asn Val Ile  Tyr His Ala Val Lys  Asp Ala Val 
    1295                 1300                 1305             


Ala Met  Leu Lys Ala Ser Glu  Ser Ser Phe Gly Lys  Pro 
    1310                 1315                 1320     


<210>  7791
<211>  4502
<212>  DNA
<213>  Homosapiens

<400>  7791
agacccggtg ggcacaaggc ctcttgcctg ttcctcactt ctcaggtctc tgttggtgag     60

tcctccatgt gctgtgggtc tgcagtgtgc tctctcgagg tcctgtccct cgagcccctc    120

agagactgat taaagcagct gcatggttgg gatcttgggc aaacttaagt atataagagc    180

atttttccaa taaattgtat agtttatcca tgctttatag aaatcctgaa gctttaaagg    240

tgggtatctg agaaattttc aaaagaattg cttgcgtggt ttaactagct tggcagcggg    300

tctttccccc tagacactaa tagatggcag tgttactcta taaaagcttt tcctatgaca    360

aaatggttcc catccagaag caagcattca gaaggatgaa aataatgatg tgttcatttt    420

caaacacctt atatcttatt gtaaacatca ttaaagagtg gtcttttcaa aggttgtgtg    480

attgagctgt gactcttcca tgagagtaag tgcaaaggct ctttggagag atcatataat    540

ccagcctctc ttcagttcct gcaacacccc ccattttgca aatgaggacc aggacttgcg    600

gacagtagaa ggggcattga cttgttcagg atctccaagg ggcagctagt ggcaggtctg    660

aaactagtac ttagatctcc tgatttccaa gctagagccc atttccctac tcttccccca    720

ctcttaactc cccatcaccc aacagcccct actgtttcag ctttttttcc cccttaaaag    780

tccatggtgt tttgtttcag gatgttttgt tgtctagcac tcctttccct ttgaccatta    840

tgtttttaca attttggttt catctcagtt taccatggtt tagagtctgg ttttatcaat    900

gtacagttac ccatgactgg gatccagtgg actttgggcc agtggctggg cagcagttat    960

ttccttgctc gttttgcact gtggcactgg ctggatcagc aggcagccag tcctgctgag   1020

gctttgcctc ctagtctcct ttccttactt ttcttgccag ctccatcctc ttcctattgc   1080

ccttagtcta accaccatct tcaagtttgt gtttatcgtt tgcttatatt tacaatttta   1140

acatatatat ttgtattcct gcacaatatt ctttcagttt ttagcctgct tttgaacttc   1200

atataaatag aatcagattt tttatattca tccatgctgt catatatcat ccatgtgttc   1260

atttcattca ttttatttct attacattaa ttgctttttt ctgaaatttt gctttttact   1320

atggaactat ttttcaaata cagtgaaaac ttgagagtct ggtagtgact ccatataact   1380

catcacccag ttatataaca gcttttaact ttttgccata atcgtttcat tgtcttctct   1440

ctttatgttt tttcatcatc ctctcaacta tcctatgatt tcaccctaat accaaacgct   1500

ttacctactc ccaggactga tatttcagca agctggaaag aaaggaaagt acaacagggc   1560

tctgggggcc ctggtcccaa gctggagtga agaaatgtgc cctctcaaaa gtatagcccc   1620

tctaaaacca aagccccagg caagccagag ataaagcctt cctccaaaac agtattatgg   1680

ggcgttttca gaggctggca ggttagaaaa cagccgctgc ttgctcacta caagctgtgc   1740

ttctccctac tgcccagtct aagaagcaga gtcctggtgt tacaatgggt tgcccaaagt   1800

gactgcaggg taagcttcag gatgattgtt gagcaaggtg agctttctcc tgtgagcaag   1860

gaattagcca cagactgaac actgtggggg acctgtcttt ctggctcact cctcacccct   1920

cctcttttac agttgagaga accaaggaat gcgttgggca gtattccttc ttatactcat   1980

gatagccatt tgacgttcca ggtttatgtg tgtgtgtggg tgggtgcttt cccttggact   2040

ccccatctcg agtggtcctt gggctttgtc tcttgcccca gaactcctag gctgtggcaa   2100

caatcaaagc ctgagctcac ttgatctagc agatgtcctt ttggcaaatc ccagcttcgg   2160

aagcctgctt taaccacttc catttcctgc tgtttttggc ttctgagtat tccttctttt   2220

cttgctagca catcgattgg ttaaagaatt tttttgcaat aatttgatcc agaattttta   2280

ttctcagcag aagagtcaat cagggaccta ccatccccca ggtaggtagt ggaaagactg   2340

tggcagcctt tgttgtcttt tgtaaaactt aaggcacttt gtttttgcag gattaatcac   2400

tcctgaagat cggaaatatg gaacaacaaa tcttcactta gatgtatctg atgcagctaa   2460

tgtcatggtc tatgtgggaa ttcccaaagg acagtgtgag caagaagaag gtagggtgct   2520

gagcataaaa ggagggctta ctctttgagc cagggcttgt ggtctgatat ctgctttctc   2580

ttcttgctct agaagtcctt aagaccatcc aagatggaga ttctgacgaa ctcacaataa   2640

agcgatttat tgaaggaaaa gagaagccag gagcactgtg gcacatatat gctgcaaagg   2700

acacggagaa gataagggaa tttcttaaaa aggtatcaga agagcaaggt caagaaaacc   2760

cagcagacca cgatcctatt catgatcaaa gctggtattt agaccgatca ttaagaaaac   2820

gtcttcatca agagtatgga gttcaaggct gggctattgt acagtttctt ggggatgtgg   2880

tgtttatccc ggcaggagct ccacatcagg ttcataactt atatagctgc atcaaagtgg   2940

ctgaagattt tgtttctcca gagcatgtta aacactgctt ctggcttact caggaattcc   3000

gatatctgtc acagactcat accaatcacg aagataaatt acaggtaaaa atagcaccaa   3060

ttcctagcat tctttggcta tggctatggc ttcatggccc attcttcacc ttataaagag   3120

agtcagtgaa cttggccata tcgtacttag tacacagtga gtcgaggaac ttgctttata   3180

tctagtacta ctatctactt aagtgaggga ggaacaagag gaaatctcac cttggtttga   3240

tttgatattg tttagaatct ataagggact gtccccacag agaaaggcct tagtactgaa   3300

aatgaataga tgtgacttct gatcttggcc cagctgcctg tcggggtctt gaacacagtg   3360

cttaaccttc agtgctgcag tgttctcatc actcttaggt agagcagaac tgaatctctg   3420

agactcaaag aggtctgagg gggtggtatt ttcaaaagga tttcagtaat gaattatgta   3480

acataatttc atgtttggaa aataagggaa aaatgataaa agctgtacct tggaacttgc   3540

ctctccctgt actcactgtg agtaggtcta cgtggtatca aaacctctaa aagggggaaa   3600

atgagttctt gaaatcatgg gtttaaaatg tatgtgaaat actggtctga aggagcccag   3660

ggaccttttg caatgttgac atttcatacg aatattgaat tttaaattct gagagaaggt   3720

aataaaatta gtaggaggaa gcttattctt agtgacaggt tttagattta aatgtaaaat   3780

gcccatattt tctcctacta tttttaggtg aagaatgtta tctaccatgc agtgaaagat   3840

gcagttgcta tgctgaaagc cagtgaatcc agttttggca aaccttaatc tccctgcaca   3900

ttggaaatga attacaggca gctgttcaaa ctcttcaggc aggattcctg tggactttga   3960

gattcatgtt acctcatctt cttttttaaa ctgtacccaa cttgtgaggg tactctgtct   4020

aatgtatatt tctagtgttt acagacagta aatgtgtata tgtagtaact atttacagaa   4080

catgcatcct taaactgtga cttctcacct agtgcagaac ttttaccagg ctgtaaaagc   4140

aaaacctcgt atcagctctg gaacaatacc tgcagttatt cttcagctgt ttggacaact   4200

tagattgggt ttataactat taggaatcac tgcacagttt atttgggttg tgttttgtgt   4260

ctgagtcccc tccctcatcc cttagggtcc agaagagcaa tggaggaagt gacagctaat   4320

gttgcagttc ttattgtatg gcataggact ggcattatat agcagaaatc aactactgta   4380

caatttcttg gggttaacca tctttagtta aatggaattt taatttaaat gacgctttgc   4440

taattttaag tgttaagcat tttgcattaa aatattcata taatattttg gctcagttta   4500

tt                                                                  4502


<210>  7792
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  7792

Met Glu Phe Lys Ala Gly Leu Leu Tyr Ser Phe Leu Gly Met Trp Cys 
1               5                   10                  15      


Leu Ser Arg Gln Glu Leu His Ile Arg Phe Ile Thr Tyr Ile Ala Ala 
            20                  25                  30          


Ser Lys Trp Leu Lys Ile Leu Phe Leu Gln Ser Met Leu Asn Thr Ala 
        35                  40                  45              


Ser Gly Leu Leu Arg Asn Ser Asp Ile Cys His Arg Leu Ile Pro Ile 
    50                  55                  60                  


Thr Lys Ile Asn Tyr Arg 
65                  70  


<210>  7793
<211>  2973
<212>  DNA
<213>  Homosapiens

<400>  7793
ttccccctta aaagtccatg gtgttttgtt tcaggatgtt ttgttgtcta gcactccttt     60

ccctttgacc attatgtttt tacaattttg gtttcatctc agtttaccat ggtttagagt    120

ctggttttat caatgtacag ttacccatga ctgggatcca gtggactttg ggccagtggc    180

tgggcagcag ttatttcctt gctcgttttg cactgtggca ctggctggat cagcaggcag    240

ccagtcctgc tgaggctttg cctcctagtc tcctttcctt acttttcttg ccagctccat    300

cctcttccta ttgcccttag tctaaccacc atcttcaagt ttgtgtttat cgtttgctta    360

tatttacaat tttaacatat atatttgtat tcctgcacaa tattctttca gtttttagcc    420

tgcttttgaa cttcatataa atagaatcag attttttata ttcatccatg ctgtcatata    480

tcatccatgt gttcatttca ttcattttat ttctattaca ttaattgctt ttttctgaaa    540

ttttgctttt tactatggaa ctatttttca aatacagtga aaacttgaga gtctggtagt    600

gactccatat aactcatcac ccagttatat aacagctttt aactttttgc cataatcgtt    660

tcattgtctt ctctctttat gttttttcat catcctctca actatcctat gatttcaccc    720

taataccaaa cgctttacct actcccagga ctgatatttc agcaagctgg aaagaaagga    780

aagtacaaca gggctctggg ggccctggtc ccaagctgga gtgaagaaat gtgccctctc    840

aaaagtatag cccctctaaa accaaagccc caggcaagcc agagataaag ccttcctcca    900

aaacagtatt atggggcgtt ttcagaggct ggcaggttag aaaacagccg ctgcttgctc    960

actacaagct gtgcttctcc ctactgccca gtctaagaag cagagtcctg gtgttacaat   1020

gggttgccca aagtgactgc agggtaagct tcaggatgat tgttgagcaa ggtgagcttt   1080

ctcctgtgag caaggaatta gccacagact gaacactgtg ggggacctgt ctttctggct   1140

cactcctcac ccctcctctt ttacagttga gagaaccaag gaatgcgttg ggcagtattc   1200

cttcttatac tcatgatagc catttgacgt tccaggttta tgtgtgtgtg tgggtgggtg   1260

ctttcccttg gactccccat ctcgagtggt ccttgggctt tgtctcttgc cccagaactc   1320

ctaggctgtg gcaacaatca aagcctgagc tcacttgatc tagcagatgt ccttttggca   1380

aatcccagct tcggaagcct gctttaacca cttccatttc ctgctgtttt tggcttctga   1440

gtattccttc ttttcttgct agcacatcga ttggttaaag aatttttttg caataatttg   1500

atccagaatt tttattctca gcagaagagt caatcaggga cctaccatcc cccaggtagg   1560

tagtggaaag actgtggcag cctttgttgt cttttgtaaa acttaaggca ctttgttttt   1620

gcaggattaa tcactcctga agatcggaaa tatggaacaa caaatcttca cttagatgta   1680

tctgatgcag ctaatgtcat ggtctatgtg ggaattccca aaggacagtg tgagcaagaa   1740

gaaggtaggg tgctgagcat aaaaggaggg cttactcttt gagccagggc ttgtggtctg   1800

atatctgctt tctcttcttg ctctagaagt ccttaagacc atccaagatg gagattctga   1860

cgaactcaca ataaagcgat ttattgaagg aaaagagaag ccaggagcac tgtggcacat   1920

atatgctgca aaggacacgg agaagataag ggaatttctt aaaaaggtat cagaagagca   1980

aggtcaagaa aacccagcag accacgatcc tattcatgat caaagctggt atttagaccg   2040

atcattaaga aaacgtcttc atcaagagta tggagttcaa ggctgggcta ttgtacagtt   2100

tcttggggat gtggtgttta tcccggcagg agctccacat caggttcata acttatatag   2160

ctgcatcaaa gtggctgaag attttgtttc tccagagcat gttaaacact gcttctggct   2220

tactcaggaa ttccgatatc tgtcacagac tcataccaat cacgaagata aattacaggt   2280

gaagaatgtt atctaccatg cagtgaaaga tgcagttgct atgctgaaag ccagtgaatc   2340

cagttttggc aaaccttaat ctccctgcac attggaaatg aattacaggc agctgttcaa   2400

actcttcagg caggattcct gtggactttg agattcatgt tacctcatct tcttttttaa   2460

actgtaccca acttgtgagg gtactctgtc taatgtatat ttctagtgtt tacagacagt   2520

aaatgtgtat atgtagtaac tatttacaga acatgcatcc ttaaactgtg acttctcacc   2580

tagtgcagaa cttttaccag gctgtaaaag caaaacctcg tatcagctct ggaacaatac   2640

ctgcagttat tcttcagctg tttggacaac ttagattggg tttataacta ttaggaatca   2700

ctgcacagtt tatttgggtt gtgttttgtg tctgagtccc ctccctcatc ccttagggtc   2760

cagaagagca atggaggaag tgacagctaa tgttgcagtt cttattgtat ggcataggac   2820

tggcattata tagcagaaat caactactgt acaatttctt ggggttaacc atctttagtt   2880

aaatggaatt ttaatttaaa tgacgctttg ctaattttaa gtgttaagca ttttgcatta   2940

aaatattcat ataatatttt ggctcagttt att                                2973


<210>  7794
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  7794

Met Glu Phe Lys Ala Gly Leu Leu Tyr Ser Phe Leu Gly Met Trp Cys 
1               5                   10                  15      


Leu Ser Arg Gln Glu Leu His Ile Arg Phe Ile Thr Tyr Ile Ala Ala 
            20                  25                  30          


Ser Lys Trp Leu Lys Ile Leu Phe Leu Gln Ser Met Leu Asn Thr Ala 
        35                  40                  45              


Ser Gly Leu Leu Arg Asn Ser Asp Ile Cys His Arg Leu Ile Pro Ile 
    50                  55                  60                  


Thr Lys Ile Asn Tyr Arg 
65                  70  


<210>  7795
<211>  4176
<212>  DNA
<213>  Homosapiens

<400>  7795
ttccccctta aaagtccatg gtgttttgtt tcaggatgtt ttgttgtcta gcactccttt     60

ccctttgacc attatgtttt tacaattttg gtttcatctc agtttaccat ggtttagagt    120

ctggttttat caatgtacag ttacccatga ctgggatcca gtggactttg ggccagtggc    180

tgggcagcag ttatttcctt gctcgttttg cactgtggca ctggctggat cagcaggcag    240

ccagtcctgc tgaggctttg cctcctagtc tcctttcctt acttttcttg ccagctccat    300

cctcttccta ttgcccttag tctaaccacc atcttcaagt ttgtgtttat cgtttgctta    360

tatttacaat tttaacatat atatttgtat tcctgcacaa tattctttca gtttttagcc    420

tgcttttgaa cttcatataa atagaatcag attttttata ttcatccatg ctgtcatata    480

tcatccatgt gttcatttca ttcattttat ttctattaca ttaattgctt ttttctgaaa    540

ttttgctttt tactatggaa ctatttttca aatacagtga aaacttgaga gtctggtagt    600

gactccatat aactcatcac ccagttatat aacagctttt aactttttgc cataatcgtt    660

tcattgtctt ctctctttat gttttttcat catcctctca actatcctat gatttcaccc    720

taataccaaa cgctttacct actcccagga ctgatatttc agcaagctgg aaagaaagga    780

aagtacaaca gggctctggg ggccctggtc ccaagctgga gtgaagaaat gtgccctctc    840

aaaagtatag cccctctaaa accaaagccc caggcaagcc agagataaag ccttcctcca    900

aaacagtatt atggggcgtt ttcagaggct ggcaggttag aaaacagccg ctgcttgctc    960

actacaagct gtgcttctcc ctactgccca gtctaagaag cagagtcctg gtgttacaat   1020

gggttgccca aagtgactgc agggtaagct tcaggatgat tgttgagcaa ggtgagcttt   1080

ctcctgtgag caaggaatta gccacagact gaacactgtg ggggacctgt ctttctggct   1140

cactcctcac ccctcctctt ttacagttga gagaaccaag gaatgcgttg ggcagtattc   1200

cttcttatac tcatgatagc catttgacgt tccaggttta tgtgtgtgtg tgggtgggtg   1260

ctttcccttg gactccccat ctcgagtggt ccttgggctt tgtctcttgc cccagaactc   1320

ctaggctgtg gcaacaatca aagcctgagc tcacttgatc tagcagatgt ccttttggca   1380

aatcccagct tcggaagcct gctttaacca cttccatttc ctgctgtttt tggcttctga   1440

gtattccttc ttttcttgct agcacatcga ttggttaaag aatttttttg caataatttg   1500

atccagaatt tttattctca gcagaagagt caatcaggga cctaccatcc cccaggtagg   1560

tagtggaaag actgtggcag cctttgttgt cttttgtaaa acttaaggca ctttgttttt   1620

gcaggattaa tcactcctga agatcggaaa tatggaacaa caaatcttca cttagatgta   1680

tctgatgcag ctaatgtcat ggtctatgtg ggaattccca aaggacagtg tgagcaagaa   1740

gaaggtaggg tgctgagcat aaaaggaggg cttactcttt gagccagggc ttgtggtctg   1800

atatctgctt tctcttcttg ctctagaagt ccttaagacc atccaagatg gagattctga   1860

cgaactcaca ataaagcgat ttattgaagg aaaagagaag ccaggagcac tgtggcacat   1920

atatgctgca aaggacacgg agaagataag ggaatttctt aaaaaggtat cagaagagca   1980

aggtcaagaa aacccagcag accacgatcc tattcatgat caaagctggt atttagaccg   2040

atcattaaga aaacgtcttc atcaagagta tggagttcaa ggctgggcta ttgtacagtt   2100

tcttggggat gtggtgttta tcccggcagg agctccacat caggttcata acttatatag   2160

ctgcatcaaa gtggctgaag attttgtttc tccagagcat gttaaacact gcttctggct   2220

tactcaggaa ttccgatatc tgtcacagac tcataccaat cacgaagata aattacaggt   2280

gaagaatgtt atctaccatg cagtgaaaga tgcagttgct atgctgaaag ccagtgaatc   2340

cagttttggc aaaccttaat ctccctgcac attggaaatg aattacaggc agctgttcaa   2400

actcttcagg caggattcct gtggactttg agattcatgt tacctcatct tcttttttaa   2460

actgtaccca acttgtgagg gtactctgtc taatgtatat ttctagtgtt tacagacagt   2520

aaatgtgtat atgtagtaac tatttacaga acatgcatcc ttaaactgtg acttctcacc   2580

tagtgcagaa cttttaccag gctgtaaaag caaaacctcg tatcagctct ggaacaatac   2640

ctgcagttat tcttcagctg tttggacaac ttagattggg tttataacta ttaggaatca   2700

ctgcacagtt tatttgggtt gtgttttgtg tctgagtccc ctccctcatc ccttagggtc   2760

cagaagagca atggaggaag tgacagctaa tgttgcagtt cttattgtat ggcataggac   2820

tggcattata tagcagaaat caactactgt acaatttctt ggggttaacc atctttagtt   2880

aaatggaatt ttaatttaaa tgacgctttg ctaattttaa gtgttaagca ttttgcatta   2940

aaatattcat ataatatttt ggctcagttt attggcatta tcctctcatt gtggtttcaa   3000

cacaactttc ttcaaatgca ggtgtaatgg attgctccaa gaactcttct taaaagcaaa   3060

gaaatcagat gctatagtga ttttcttagt gattattaca aagctaacat ggaaatttct   3120

gctcagccag gtagaaaccc tgtcacactt tgtcaaggaa acaccaccaa ttaattaaat   3180

ttagaaacag gaattaacca agaaaccaaa tagtgccagg ctaaatggtt ctaaaaaggt   3240

aagtaatgaa acactttgtt ttatggccct tcataatgtt aagtttatga aggaaaatga   3300

aattataagt tctaggacag tactacctaa aatattcatc tctgtgaagg aaaaaaattc   3360

acaaagaagc gcctttcttt agcccactga ttctcctagg ccactctttc atttaatttc   3420

tttaaaaaaa ggaattaaac atagaaatca gatagtacat agacaaagcc tagaacctga   3480

gttttaattt gtgagctgag taggaggcca gaggatccgt attaaatttc agaacccatt   3540

gtcaaatcta aggtcaaaga tttgctctaa tgttttcttc taggagtttt aaaattttag   3600

cccttaaatt aagtctttga cctattttga gttaattatt aaatatggtg taaagattca   3660

acttcatttt tttgaatatg gatatccagt tttcccagca acatttgtcg tcaaacactg   3720

ttctttcccc cattgaatgg tcttggcact ctagttaaaa atcaattgat cgtagatggg   3780

aaagcatatt actaggctct catattccac tggtctgtgt atctgtcttt atgccagtac   3840

tgcactgttt tgatttctgc tactttgtag taagttttaa aatcaacaac tgtgagttct   3900

ccaactctgg tcttcttttt catgattgtt ttaatcaggg tcactggaaa ttccgtacga   3960

attttgggat aggttttttt atttctgcaa aaaacaccat ctgggtatta atagagattg   4020

cattgaacct gtatgttcct ttgggtgtca tcttaacaat ctaattcttg caatccatga   4080

gcatgggatg ttgtgtttcc atttattggt gtcttcttta atgtctttca gcaatgtttt   4140

gtagttttca gttgcatgag ttttgtacct tcatgg                             4176


<210>  7796
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  7796

Met Glu Phe Lys Ala Gly Leu Leu Tyr Ser Phe Leu Gly Met Trp Cys 
1               5                   10                  15      


Leu Ser Arg Gln Glu Leu His Ile Arg Phe Ile Thr Tyr Ile Ala Ala 
            20                  25                  30          


Ser Lys Trp Leu Lys Ile Leu Phe Leu Gln Ser Met Leu Asn Thr Ala 
        35                  40                  45              


Ser Gly Leu Leu Arg Asn Ser Asp Ile Cys His Arg Leu Ile Pro Ile 
    50                  55                  60                  


Thr Lys Ile Asn Tyr Arg 
65                  70  


<210>  7797
<211>  3175
<212>  DNA
<213>  Homosapiens

<400>  7797
tagtgccgcc gctccctact ctgggggttg ggactacctc cttttccgcg ggccccgccc     60

aggcggctgc ccgtgacctg cctgggcgcg gggaactgaa agccggaagg ggcaagacgg    120

gttcagttcg tcatggggct gtttggaaag acccaggaga agccgcccaa agaactggtc    180

aatgagtggt cattgaagat aagaaaggaa atgagagttg ttgacaggca aataagggat    240

atccaaagag aagaagaaaa agtgaaacga tctgtgaaag atgctgccaa gaagggccag    300

aaggatgtct gcatagttct ggccaaggag atgatcaggt caaggaaggc tgtgagcaag    360

ctgtatgcat ccaaagcaca catgaactca gtgctcatgg ggatgaagaa ccagctcgcg    420

gtcttgcgag tggctggttc cctgcagaag agcacagaag tgatgaaggc catgcaaagt    480

cttgtgaaga ttccagagat tcaggccacc atgagggagt tgtccaaaga aatgatgaag    540

gctgggatca tagaggagat gttagaggac acttttgaaa gcatggacga tcaggaagaa    600

atggaggaag aagcagaaat ggaaattgac agaattctct ttgaaattac agcaggggcc    660

ttgggcaaag cacccagtaa agtgactgat gcccttccag agccagaacc tccaggagcg    720

atggctgcct cagaggatga ggaggaggag gaagaggctc tggaggccat gcagtcccgg    780

ctggccacac tccgcagcta ggggctgcct accccgctgg gtgtgcacac actcctctca    840

agagctgcca ttttatgtgt ctcttgcact acacctctgt tgtgaggact accattttgg    900

agaaggttct gtttgtctct tttcattctc tgcccaggtt ttgggatcgc aaagggattg    960

ttcttataaa agtggcataa ataaatgcat catttttagg agtatagaca gatatatctt   1020

attgtgggga ggggaaagaa atccatctgc tcatgaagca cttctgaaaa tataggtgat   1080

tgcctgaatg tcgaagactc tacttttgtc tataaaacac tatataaatg aattttaata   1140

aatttttgct ttagcacttg gccccattgt agattgccct gtgcagtaaa ctttcaaggt   1200

gtcggctgcc ccagattgct tcatttgctg ggtgtggaaa gagttgctat ggccaggcat   1260

atgggatttg gaagctcagc agaagtgact tctgctctgt ggttgctgct ccccggcttt   1320

cacagacatg gtatggcagc cattctttta tctatttaac caagaggatg ctggggaatt   1380

gtgctgcttg tcctgttggc tggtggctgc attatgtcct ggggtgtgca tgtgggtcta   1440

tttagagctt ctgtcccttc cttcccattg caagttgcac ccagatgaga cagctgtagt   1500

actaggtctc tttcacctct cattgcctgt ccctgcttcg agctggttgt cttgtgcgtg   1560

ggacatgggc cttcctatct gtgttttctc aaagtcagga gctgaccagg agcacactaa   1620

ggtgtggtca tgcatcataa ccaacattca ctcatctggg acattcttaa gatacattta   1680

taaatcattt cagcagtagt actttgtatg tgttgagagt ttacagagct ctttgacata   1740

cgcgatctta gtctttacaa ataaggaaaa cagctcagtt tgggaagtat cagagatggg   1800

attcaaaccc agatcctctg gtccaagttg tatgtgcact gaactaatca ggcaggaaaa   1860

aagcccagcc actgtctcac agattgtttt ttgtatattg tagcaaaatc ctgaaacaat   1920

ggggtccttc cagtctcatc atacaaaatg gcaatcttgg ctgggtgcgg tggttcatgc   1980

ctataatccc agtgctttac aaggctgagg caggaggctc tcttgagaat aggagttcaa   2040

gaccagcctg ggcaacatag caagatcctg tctctccaaa aaaaaaaaaa aaaaaaaaaa   2100

aaaatttcat ttttgagtcc agaggaccct cctattactc ttgatttcat cttcagagtg   2160

tagttaaaaa attattttaa ataattattt ttttaaatca gttgtaggtt cacagcaaaa   2220

gtggacaaaa agaaatttct catatatccc ctgccctcac acatgcatag cctcccacca   2280

ctatcagtat cccacaccag agtggtacat ttgttacaat caataaacct ccattgacac   2340

atcattatca cccaaagtcc atagtttaca tgaagattca ctctggtgtt gtacattgta   2400

tgggcttaga caaatgtatg atgatatcta caattataga atcatacaga atagtttcac   2460

tgccctaaaa cttctctatg cttcacctgt tcatcccttt cttccctaat cccctggcaa   2520

ccactttaaa aaaaaaatta ggttcagggg gtacatgtgc aggtaaactc gtgacaaggg   2580

ggtttgttat acagattatt tagtgaccca ggtactaagc ctagtaccca atagttactt   2640

ttctggtcct gtcccttttc ccaccctcca ccctcaggta ggccccagta tgttattcct   2700

ttgtgtccat gttatttcac tcccacttgt gagaacatgg aatatttggt ttcctgttcc   2760

tatgttagtt tgttaaggat aatggcctcc agccccatcc atgttcctgc aaaggacatg   2820

atctttcttt ggcaaccact ttttactgtc gccatagttc ttccttttct agaatgtcat   2880

attggaatca tatagtatgt agccttttca gactggcttc tttcacttaa taatatgcaa   2940

ttaaggttcc tccatgtcat ttcatggctt aatagtgcat ttatttttag cactgaataa   3000

tactccattg tctagatgaa tagtttatcc attcacctat tgaaagactt cttggtggtt   3060

tccaagtttt ggcaattatg aataaagctg ttgtaaacat ctttgtgcag gtttttctat   3120

gggcatgttt ttaattcatt tgaataaata ccaagagctt cagtgctgga tcata        3175


<210>  7798
<211>  222
<212>  PRT
<213>  Homosapiens

<400>  7798

Met Gly Leu Phe Gly Lys Thr Gln Glu Lys Pro Pro Lys Glu Leu Val 
1               5                   10                  15      


Asn Glu Trp Ser Leu Lys Ile Arg Lys Glu Met Arg Val Val Asp Arg 
            20                  25                  30          


Gln Ile Arg Asp Ile Gln Arg Glu Glu Glu Lys Val Lys Arg Ser Val 
        35                  40                  45              


Lys Asp Ala Ala Lys Lys Gly Gln Lys Asp Val Cys Ile Val Leu Ala 
    50                  55                  60                  


Lys Glu Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser 
65                  70                  75                  80  


Lys Ala His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala 
                85                  90                  95      


Val Leu Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys 
            100                 105                 110         


Ala Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg 
        115                 120                 125             


Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu 
    130                 135                 140                 


Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu 
145                 150                 155                 160 


Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala 
                165                 170                 175     


Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu 
            180                 185                 190         


Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu 
        195                 200                 205             


Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
    210                 215                 220         


<210>  7799
<211>  1819
<212>  DNA
<213>  Homosapiens

<400>  7799
caggggcctt gggcaaagca cccagtaaag tgactgatgc ccttccagag ccagaacctc     60

caggagcgat ggctgcctca gaggatgagg aggaggagga agaggctctg gaggccatgc    120

agtcccggct ggccacactc cgcagctagg ggctgcctac cccgctgggt gtgcacacac    180

tcctctcaag agctgccatt ttatgtgtct cttgcactac acctctgttg tgaggactac    240

cattttggag aaggttctgt ttgtctcttt tcattctctg cccaggtttt gggatcgcaa    300

agggattgtt cttataaaat ataggtgatt gcctgaatgt cgaagactct acttttgtct    360

ataaaacact atataaatga attttaataa atttttgctt tagcacttgg ccccattgta    420

gattgccctg tgcagtaaac tttcaaggtg tcggctgccc cagattgctt catttgctgg    480

gtgtggaaag agttgctatg gccaggcata tgggatttgg aagctcagca gaagtgactt    540

ctgctctgtg gttgctgctc cccggctttc acagacatgg tatggcagcc attcttttat    600

ctatttaacc aagaggatgc tggggaattg tgctgcttgt cctgttggct ggtggctgca    660

ttatgtcctg gggtgtgcat gtgggtctat ttagagcttc tgtcccttcc ttcccattgc    720

aagttgcacc cagatgagac agctgtagta ctaggtctct ttcacctctc attgcctgtc    780

cctgcttcga gctggttgtc ttgtgcgtgg gacatgggcc ttcctatctg tgttttctca    840

aagtcaggag ctgaccagga gcacactaag gtgtggtcat gcatcataac caacattcac    900

tcatctggga cattcttaag atacatttat aaatcatttc agcagtagta ctttgtatgt    960

gttgagagtt tacagagctc tttgacatac gcgatcttag tctttacaaa taaggaaaac   1020

agctcagttt gggaagtatc agagatggga ttcaaaccca gatcctctgg tccaagttgt   1080

atgtgcactg aactaatcag gcaggaaaaa agcccagcca ctgtctcaca gattgttttt   1140

tgtatattgt agcaaaatcc tgaaacaatg gggtccttcc agtctcatca tacaaaatgg   1200

caatcttggc tgggtgcggt ggttcatgcc tataatccca gtgctttaca aggctgaggc   1260

aggaggctct cttgagaata ggagttcaag accagcctgg gcaacatagc aagatcctgt   1320

ctctccaaaa aaaaaaaaaa aaaaaaaaaa aaatttcatt tttgagtcca gaggaccctc   1380

ctattactct tgatttcatc ttcagagtgt agttaaaaaa ttattttaaa taattatttt   1440

tttaaatcag ttgtaggttc acagcaaaag tggacaaaaa gaaatttctc atatatcccc   1500

tgccctcaca catgcatagc ctcccaccac tatcagtatc ccacaccaga gtggtacatt   1560

tgttacaatc aataaacctc cattgacaca tcattatcac ccaaagtcca tagtttacat   1620

gaagattcac tctggtgttg tacattgtat gggcttagac aaatgtatga tgatatctac   1680

aattatagaa tcatacagaa tagtttcact gccctaaaac ttctctatgc ttcacctgtt   1740

catccctttc ttccctaatc ccctggcaac cactttaaaa aaaaaattag gttcaggggg   1800

tacatgtgca ggtaaactc                                                1819


<210>  7800
<211>  95
<212>  PRT
<213>  Homosapiens

<400>  7800

Met Pro Phe Gln Ser Gln Asn Leu Gln Glu Arg Trp Leu Pro Gln Arg 
1               5                   10                  15      


Met Arg Arg Arg Arg Lys Arg Leu Trp Arg Pro Cys Ser Pro Gly Trp 
            20                  25                  30          


Pro His Ser Ala Ala Arg Gly Cys Leu Pro Arg Trp Val Cys Thr His 
        35                  40                  45              


Ser Ser Gln Glu Leu Pro Phe Tyr Val Ser Leu Ala Leu His Leu Cys 
    50                  55                  60                  


Cys Glu Asp Tyr His Phe Gly Glu Gly Ser Val Cys Leu Phe Ser Phe 
65                  70                  75                  80  


Ser Ala Gln Val Leu Gly Ser Gln Arg Asp Cys Ser Tyr Lys Ile 
                85                  90                  95  


<210>  7801
<211>  2467
<212>  DNA
<213>  Homosapiens

<400>  7801
ggggggccgg aggaagagtc tttaggagtc ggctgtggga cgcgagagct cctggtgcca     60

tggctctcga acaggtcaat gagtggtcat tgaagataag aaaggaaatg agagttgttg    120

acaggcaaat aagggatatc caaagagaag aagaaaaagt gaaacgatct gtgaaagatg    180

ctgccaagaa gggccagaag gatgtctgca tagttctggc caaggagatg atcaggtcaa    240

ggaaggctgt gagcaagctg tatgcatcca aagcacacat gaactcagtg ctcatgggga    300

tgaagaacca gctcgcggtc ttgcgagtgg ctggttccct gcagaagagc acagaagtga    360

tgaaggccat gcaaagtctt gtgaagattc cagagattca ggccaccatg agggagttgt    420

ccaaagaaat gatgaaggct gggatcatag aggagatgtt agaggacact tttgaaagca    480

tggacgatca ggaagaaatg gaggaagaag cagaaatgga aattgacaga attctctttg    540

aaattacagc aggggccttg ggcaaagcac ccagtaaagt gactgatgcc cttccagagc    600

cagaacctcc aggagcgatg gctgcctcag aggatgagga ggaggaggaa gaggctctgg    660

aggccatgca gtcccggctg gccacactcc gcagctaggg gctgcctacc ccgctgggtg    720

tgcacacact cctctcaaga gctgccattt tatgtgtctc ttgcactaca cctctgttgt    780

gaggactacc attttggaga aggttctgtt tgtctctttt cattctctgc ccaggttttg    840

ggatcgcaaa gggattgttc ttataaaagt ggcataaata aatgcatcat ttttaggagt    900

atagacagat atatcttatt gtggggaggg gaaagaaatc catctgctca tgaagcactt    960

ctgaaaatat aggtgattgc ctgaatgtcg aagactctac ttttgtctat aaaacactat   1020

ataaatgaat tttaataaat ttttgcttta gcacttggcc ccattgtaga ttgccctgtg   1080

cagtaaactt tcaaggtgtc ggctgcccca gattgcttca tttgctgggt gtggaaagag   1140

ttgctatggc caggcatatg ggatttggaa gctcagcaga agtgacttct gctctgtggt   1200

tgctgctccc cggctttcac agacatggta tggcagccat tcttttatct atttaaccaa   1260

gaggatgctg gggaattgtg ctgcttgtcc tgttggctgg tggctgcatt atgtcctggg   1320

gtgtgcatgt gggtctattt agagcttctg tcccttcctt cccattgcaa gttgcaccca   1380

gatgagacag ctgtagtact aggtctcttt cacctctcat tgcctgtccc tgcttcgagc   1440

tggttgtctt gtgcgtggga catgggcctt cctatctgtg ttttctcaaa gtcaggagct   1500

gaccaggagc acactaaggt gtggtcatgc atcataacca acattcactc atctgggaca   1560

ttcttaagat acatttataa atcatttcag cagtagtact ttgtatgtgt tgagagttta   1620

cagagctctt tgacatacgc gatcttagtc tttacaaata aggaaaacag ctcagtttgg   1680

gaagtatcag agatgggatt caaacccaga tcctctggtc caagttgtat gtgcactgaa   1740

ctaatcaggc aggaaaaaag cccagccact gtctcacaga ttgttttttg tatattgtag   1800

caaaatcctg aaacaatggg gtccttccag tctcatcata caaaatggca atcttggctg   1860

ggtgcggtgg ttcatgccta taatcccagt gctttacaag gctgaggcag gaggctctct   1920

tgagaatagg agttcaagac cagcctgggc aacatagcaa gatcctgtct ctccaaaaaa   1980

aaaaaaaaaa aaaaaaaaaa atttcatttt tgagtccaga ggaccctcct attactcttg   2040

atttcatctt cagagtgtag ttaaaaaatt attttaaata attatttttt taaatcagtt   2100

gtaggttcac agcaaaagtg gacaaaaaga aatttctcat atatcccctg ccctcacaca   2160

tgcatagcct cccaccacta tcagtatccc acaccagagt ggtacatttg ttacaatcaa   2220

taaacctcca ttgacacatc attatcaccc aaagtccata gtttacatga agattcactc   2280

tggtgttgta cattgtatgg gcttagacaa atgtatgatg atatctacaa ttatagaatc   2340

atacagaata gtttcactgc cctaaaactt ctctatgctt cacctgttca tccctttctt   2400

ccctaatccc ctggcaacca ctttaaaaaa aaaattaggt tcagggggta catgtgcagg   2460

taaactc                                                             2467


<210>  7802
<211>  212
<212>  PRT
<213>  Homosapiens

<400>  7802

Met Ala Leu Glu Gln Val Asn Glu Trp Ser Leu Lys Ile Arg Lys Glu 
1               5                   10                  15      


Met Arg Val Val Asp Arg Gln Ile Arg Asp Ile Gln Arg Glu Glu Glu 
            20                  25                  30          


Lys Val Lys Arg Ser Val Lys Asp Ala Ala Lys Lys Gly Gln Lys Asp 
        35                  40                  45              


Val Cys Ile Val Leu Ala Lys Glu Met Ile Arg Ser Arg Lys Ala Val 
    50                  55                  60                  


Ser Lys Leu Tyr Ala Ser Lys Ala His Met Asn Ser Val Leu Met Gly 
65                  70                  75                  80  


Met Lys Asn Gln Leu Ala Val Leu Arg Val Ala Gly Ser Leu Gln Lys 
                85                  90                  95      


Ser Thr Glu Val Met Lys Ala Met Gln Ser Leu Val Lys Ile Pro Glu 
            100                 105                 110         


Ile Gln Ala Thr Met Arg Glu Leu Ser Lys Glu Met Met Lys Ala Gly 
        115                 120                 125             


Ile Ile Glu Glu Met Leu Glu Asp Thr Phe Glu Ser Met Asp Asp Gln 
    130                 135                 140                 


Glu Glu Met Glu Glu Glu Ala Glu Met Glu Ile Asp Arg Ile Leu Phe 
145                 150                 155                 160 


Glu Ile Thr Ala Gly Ala Leu Gly Lys Ala Pro Ser Lys Val Thr Asp 
                165                 170                 175     


Ala Leu Pro Glu Pro Glu Pro Pro Gly Ala Met Ala Ala Ser Glu Asp 
            180                 185                 190         


Glu Glu Glu Glu Glu Glu Ala Leu Glu Ala Met Gln Ser Arg Leu Ala 
        195                 200                 205             


Thr Leu Arg Ser 
    210         


<210>  7803
<211>  2284
<212>  DNA
<213>  Homosapiens

<400>  7803
ccgcgggccc cgcccaggcg gctgcccgtg acctgcctgg gcgcggggaa ctgaaagccg     60

gaaggggcaa gacgggttca gttcgtcatg gggctgtttg gaaagaccca ggagaagccg    120

cccaaagaac tgcggtcttg cgagtggctg gttccctgca gaagagcaca gaagtgatga    180

aggccatgca aagtcttgtg aagattccag agattcaggc caccatgagg gagttgtcca    240

aagaaatgat gaaggctggg atcatagagg agatgttaga ggacactttt gaaagcatgg    300

acgatcagga agaaatggag gaagaagcag aaatggaaat tgacagaatt ctctttgaaa    360

ttacagcagg ggccttgggc aaagcaccca gtaaagtgac tgatgccctt ccagagccag    420

aacctccagg agcgatggct gcctcagagg atgaggagga ggaggaagag gctctggagg    480

ccatgcagtc ccggctggcc acactccgca gctaggggct gcctaccccg ctgggtgtgc    540

acacactcct ctcaagagct gccattttat gtgtctcttg cactacacct ctgttgtgag    600

gactaccatt ttggagaagg ttctgtttgt ctcttttcat tctctgccca ggttttggga    660

tcgcaaaggg attgttctta taaaagtggc ataaataaat gcatcatttt taggagtata    720

gacagatata tcttattgtg gggaggggaa agaaatccat ctgctcatga agcacttctg    780

aaaatatagg tgattgcctg aatgtcgaag actctacttt tgtctataaa acactatata    840

aatgaatttt aataaatttt tgctttagca cttggcccca ttgtagattg ccctgtgcag    900

taaactttca aggtgtcggc tgccccagat tgcttcattt gctgggtgtg gaaagagttg    960

ctatggccag gcatatggga tttggaagct cagcagaagt gacttctgct ctgtggttgc   1020

tgctccccgg ctttcacaga catggtatgg cagccattct tttatctatt taaccaagag   1080

gatgctgggg aattgtgctg cttgtcctgt tggctggtgg ctgcattatg tcctggggtg   1140

tgcatgtggg tctatttaga gcttctgtcc cttccttccc attgcaagtt gcacccagat   1200

gagacagctg tagtactagg tctctttcac ctctcattgc ctgtccctgc ttcgagctgg   1260

ttgtcttgtg cgtgggacat gggccttcct atctgtgttt tctcaaagtc aggagctgac   1320

caggagcaca ctaaggtgtg gtcatgcatc ataaccaaca ttcactcatc tgggacattc   1380

ttaagataca tttataaatc atttcagcag tagtactttg tatgtgttga gagtttacag   1440

agctctttga catacgcgat cttagtcttt acaaataagg aaaacagctc agtttgggaa   1500

gtatcagaga tgggattcaa acccagatcc tctggtccaa gttgtatgtg cactgaacta   1560

atcaggcagg aaaaaagccc agccactgtc tcacagattg ttttttgtat attgtagcaa   1620

aatcctgaaa caatggggtc cttccagtct catcatacaa aatggcaatc ttggctgggt   1680

gcggtggttc atgcctataa tcccagtgct ttacaaggct gaggcaggag gctctcttga   1740

gaataggagt tcaagaccag cctgggcaac atagcaagat cctgtctctc caaaaaaaaa   1800

aaaaaaaaaa aaaaaaaatt tcatttttga gtccagagga ccctcctatt actcttgatt   1860

tcatcttcag agtgtagtta aaaaattatt ttaaataatt atttttttaa atcagttgta   1920

ggttcacagc aaaagtggac aaaaagaaat ttctcatata tcccctgccc tcacacatgc   1980

atagcctccc accactatca gtatcccaca ccagagtggt acatttgtta caatcaataa   2040

acctccattg acacatcatt atcacccaaa gtccatagtt tacatgaaga ttcactctgg   2100

tgttgtacat tgtatgggct tagacaaatg tatgatgata tctacaatta tagaatcata   2160

cagaatagtt tcactgccct aaaacttctc tatgcttcac ctgttcatcc ctttcttccc   2220

taatcccctg gcaaccactt taaaaaaaaa attaggttca gggggtacat gtgcaggtaa   2280

actc                                                                2284


<210>  7804
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  7804

Met Lys Ala Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr 
1               5                   10                  15      


Met Arg Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu 
            20                  25                  30          


Met Leu Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu 
        35                  40                  45              


Glu Glu Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala 
    50                  55                  60                  


Gly Ala Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu 
65                  70                  75                  80  


Pro Glu Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
            100                 105                 110         


<210>  7805
<211>  2408
<212>  DNA
<213>  Homosapiens

<400>  7805
ccgcgggccc cgcccaggcg gctgcccgtg acctgcctgg gcgcggggaa ctgaaagccg     60

gaaggggcaa gacgggttca gttcgtcatg gggctgtttg gaaagaccca ggagaagccg    120

cccaaagaac tggtcaatga gtggtcattg aagataagaa aggaaatgag agttgttgac    180

aggcaaataa gggatatcca aagagaagaa gaaaaagtga aacgatctgt gaaagatgct    240

gccaagaagg gccagaagga tgtctgcata gttctggcca aggagatgat caggtcaagg    300

aaggctgcca tgcaaagtct tgtgaagatt ccagagattc aggccaccat gagggagttg    360

tccaaagaaa tgatgaaggc tgggatcata gaggagatgt tagaggacac ttttgaaagc    420

atggacgatc aggaagaaat ggaggaagaa gcagaaatgg aaattgacag aattctcttt    480

gaaattacag caggggcctt gggcaaagca cccagtaaag tgactgatgc ccttccagag    540

ccagaacctc caggagcgat ggctgcctca gaggatgagg aggaggagga agaggctctg    600

gaggccatgc agtcccggct ggccacactc cgcagctagg ggctgcctac cccgctgggt    660

gtgcacacac tcctctcaag agctgccatt ttatgtgtct cttgcactac acctctgttg    720

tgaggactac cattttggag aaggttctgt ttgtctcttt tcattctctg cccaggtttt    780

gggatcgcaa agggattgtt cttataaaag tggcataaat aaatgcatca tttttaggag    840

tatagacaga tatatcttat tgtggggagg ggaaagaaat ccatctgctc atgaagcact    900

tctgaaaata taggtgattg cctgaatgtc gaagactcta cttttgtcta taaaacacta    960

tataaatgaa ttttaataaa tttttgcttt agcacttggc cccattgtag attgccctgt   1020

gcagtaaact ttcaaggtgt cggctgcccc agattgcttc atttgctggg tgtggaaaga   1080

gttgctatgg ccaggcatat gggatttgga agctcagcag aagtgacttc tgctctgtgg   1140

ttgctgctcc ccggctttca cagacatggt atggcagcca ttcttttatc tatttaacca   1200

agaggatgct ggggaattgt gctgcttgtc ctgttggctg gtggctgcat tatgtcctgg   1260

ggtgtgcatg tgggtctatt tagagcttct gtcccttcct tcccattgca agttgcaccc   1320

agatgagaca gctgtagtac taggtctctt tcacctctca ttgcctgtcc ctgcttcgag   1380

ctggttgtct tgtgcgtggg acatgggcct tcctatctgt gttttctcaa agtcaggagc   1440

tgaccaggag cacactaagg tgtggtcatg catcataacc aacattcact catctgggac   1500

attcttaaga tacatttata aatcatttca gcagtagtac tttgtatgtg ttgagagttt   1560

acagagctct ttgacatacg cgatcttagt ctttacaaat aaggaaaaca gctcagtttg   1620

ggaagtatca gagatgggat tcaaacccag atcctctggt ccaagttgta tgtgcactga   1680

actaatcagg caggaaaaaa gcccagccac tgtctcacag attgtttttt gtatattgta   1740

gcaaaatcct gaaacaatgg ggtccttcca gtctcatcat acaaaatggc aatcttggct   1800

gggtgcggtg gttcatgcct ataatcccag tgctttacaa ggctgaggca ggaggctctc   1860

ttgagaatag gagttcaaga ccagcctggg caacatagca agatcctgtc tctccaaaaa   1920

aaaaaaaaaa aaaaaaaaaa aatttcattt ttgagtccag aggaccctcc tattactctt   1980

gatttcatct tcagagtgta gttaaaaaat tattttaaat aattattttt ttaaatcagt   2040

tgtaggttca cagcaaaagt ggacaaaaag aaatttctca tatatcccct gccctcacac   2100

atgcatagcc tcccaccact atcagtatcc cacaccagag tggtacattt gttacaatca   2160

ataaacctcc attgacacat cattatcacc caaagtccat agtttacatg aagattcact   2220

ctggtgttgt acattgtatg ggcttagaca aatgtatgat gatatctaca attatagaat   2280

catacagaat agtttcactg ccctaaaact tctctatgct tcacctgttc atccctttct   2340

tccctaatcc cctggcaacc actttaaaaa aaaaattagg ttcagggggt acatgtgcag   2400

gtaaactc                                                            2408


<210>  7806
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  7806

Met Gly Leu Phe Gly Lys Thr Gln Glu Lys Pro Pro Lys Glu Leu Val 
1               5                   10                  15      


Asn Glu Trp Ser Leu Lys Ile Arg Lys Glu Met Arg Val Val Asp Arg 
            20                  25                  30          


Gln Ile Arg Asp Ile Gln Arg Glu Glu Glu Lys Val Lys Arg Ser Val 
        35                  40                  45              


Lys Asp Ala Ala Lys Lys Gly Gln Lys Asp Val Cys Ile Val Leu Ala 
    50                  55                  60                  


Lys Glu Met Ile Arg Ser Arg Lys Ala Ala Met Gln Ser Leu Val Lys 
65                  70                  75                  80  


Ile Pro Glu Ile Gln Ala Thr Met Arg Glu Leu Ser Lys Glu Met Met 
                85                  90                  95      


Lys Ala Gly Ile Ile Glu Glu Met Leu Glu Asp Thr Phe Glu Ser Met 
            100                 105                 110         


Asp Asp Gln Glu Glu Met Glu Glu Glu Ala Glu Met Glu Ile Asp Arg 
        115                 120                 125             


Ile Leu Phe Glu Ile Thr Ala Gly Ala Leu Gly Lys Ala Pro Ser Lys 
    130                 135                 140                 


Val Thr Asp Ala Leu Pro Glu Pro Glu Pro Pro Gly Ala Met Ala Ala 
145                 150                 155                 160 


Ser Glu Asp Glu Glu Glu Glu Glu Glu Ala Leu Glu Ala Met Gln Ser 
                165                 170                 175     


Arg Leu Ala Thr Leu Arg Ser 
            180             


<210>  7807
<211>  2464
<212>  DNA
<213>  Homosapiens

<400>  7807
ccgcgggccc cgcccaggcg gctgcccgtg acctgcctgg gcgcggggaa ctgaaagccg     60

gaaggggcaa gacgggttca gttcgtcatg gggctgtttg gaaagaccca ggagaagccg    120

cccaaagaac tgatatccaa agagaagaag aaaaagtgaa acgatctgtg aaagatgctg    180

ccaagaaggg ccagaaggat gtctgcatag ttctggccaa ggagatgatc aggtcaagga    240

aggctgtgag caagctgtat gcatccaaag cacacatgaa ctcagtgctc atggggatga    300

agaaccagct cgcggtcttg cgagtggctg gttccctgca gaagagcaca gaagtgatga    360

aggccatgca aagtcttgtg aagattccag agattcaggc caccatgagg gagttgtcca    420

aagaaatgat gaaggctggg atcatagagg agatgttaga ggacactttt gaaagcatgg    480

acgatcagga agaaatggag gaagaagcag aaatggaaat tgacagaatt ctctttgaaa    540

ttacagcagg ggccttgggc aaagcaccca gtaaagtgac tgatgccctt ccagagccag    600

aacctccagg agcgatggct gcctcagagg atgaggagga ggaggaagag gctctggagg    660

ccatgcagtc ccggctggcc acactccgca gctaggggct gcctaccccg ctgggtgtgc    720

acacactcct ctcaagagct gccattttat gtgtctcttg cactacacct ctgttgtgag    780

gactaccatt ttggagaagg ttctgtttgt ctcttttcat tctctgccca ggttttggga    840

tcgcaaaggg attgttctta taaaagtggc ataaataaat gcatcatttt taggagtata    900

gacagatata tcttattgtg gggaggggaa agaaatccat ctgctcatga agcacttctg    960

aaaatatagg tgattgcctg aatgtcgaag actctacttt tgtctataaa acactatata   1020

aatgaatttt aataaatttt tgctttagca cttggcccca ttgtagattg ccctgtgcag   1080

taaactttca aggtgtcggc tgccccagat tgcttcattt gctgggtgtg gaaagagttg   1140

ctatggccag gcatatggga tttggaagct cagcagaagt gacttctgct ctgtggttgc   1200

tgctccccgg ctttcacaga catggtatgg cagccattct tttatctatt taaccaagag   1260

gatgctgggg aattgtgctg cttgtcctgt tggctggtgg ctgcattatg tcctggggtg   1320

tgcatgtggg tctatttaga gcttctgtcc cttccttccc attgcaagtt gcacccagat   1380

gagacagctg tagtactagg tctctttcac ctctcattgc ctgtccctgc ttcgagctgg   1440

ttgtcttgtg cgtgggacat gggccttcct atctgtgttt tctcaaagtc aggagctgac   1500

caggagcaca ctaaggtgtg gtcatgcatc ataaccaaca ttcactcatc tgggacattc   1560

ttaagataca tttataaatc atttcagcag tagtactttg tatgtgttga gagtttacag   1620

agctctttga catacgcgat cttagtcttt acaaataagg aaaacagctc agtttgggaa   1680

gtatcagaga tgggattcaa acccagatcc tctggtccaa gttgtatgtg cactgaacta   1740

atcaggcagg aaaaaagccc agccactgtc tcacagattg ttttttgtat attgtagcaa   1800

aatcctgaaa caatggggtc cttccagtct catcatacaa aatggcaatc ttggctgggt   1860

gcggtggttc atgcctataa tcccagtgct ttacaaggct gaggcaggag gctctcttga   1920

gaataggagt tcaagaccag cctgggcaac atagcaagat cctgtctctc caaaaaaaaa   1980

aaaaaaaaaa aaaaaaaatt tcatttttga gtccagagga ccctcctatt actcttgatt   2040

tcatcttcag agtgtagtta aaaaattatt ttaaataatt atttttttaa atcagttgta   2100

ggttcacagc aaaagtggac aaaaagaaat ttctcatata tcccctgccc tcacacatgc   2160

atagcctccc accactatca gtatcccaca ccagagtggt acatttgtta caatcaataa   2220

acctccattg acacatcatt atcacccaaa gtccatagtt tacatgaaga ttcactctgg   2280

tgttgtacat tgtatgggct tagacaaatg tatgatgata tctacaatta tagaatcata   2340

cagaatagtt tcactgccct aaaacttctc tatgcttcac ctgttcatcc ctttcttccc   2400

taatcccctg gcaaccactt taaaaaaaaa attaggttca gggggtacat gtgcaggtaa   2460

actc                                                                2464


<210>  7808
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  7808

Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser Lys Ala 
1               5                   10                  15      


His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala Val Leu 
            20                  25                  30          


Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys Ala Met 
        35                  40                  45              


Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg Glu Leu 
    50                  55                  60                  


Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu Glu Asp 
65                  70                  75                  80  


Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu Ala Glu 
                85                  90                  95      


Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala Leu Gly 
            100                 105                 110         


Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu Pro Pro 
        115                 120                 125             


Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu Ala Leu 
    130                 135                 140                 


Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
145                 150                 155     


<210>  7809
<211>  2426
<212>  DNA
<213>  Homosapiens

<400>  7809
cttttccgcg ggccccgccc aggcggctgc ccgtgacctg cctgggcgcg gggaactgaa     60

agccggaagg ggcaagacgg gttcagttcg tcatggggct gtttggaaag acccaggaga    120

agccgcccaa agaactgtgg agatgtgcct gcttcccctt tgccttccac catggtgtaa    180

gtttactgag gcctccccag aagcagaagc ctgtacagcc cacagaactg tgagctgatt    240

aaacctcttt tctttataaa caacccagtc tcagcggtct tgcgagtggc tggttccctg    300

cagaagagca cagaagtgat gaaggccatg caaagtcttg tgaagattcc agagattcag    360

gccaccatga gggagttgtc caaagaaatg atgaaggctg ggatcataga ggagatgtta    420

gaggacactt ttgaaagcat ggacgatcag gaagaaatgg aggaagaagc agaaatggaa    480

attgacagaa ttctctttga aattacagca ggggccttgg gcaaagcacc cagtaaagtg    540

actgatgccc ttccagagcc agaacctcca ggagcgatgg ctgcctcaga ggatgaggag    600

gaggaggaag aggctctgga ggccatgcag tcccggctgg ccacactccg cagctagggg    660

ctgcctaccc cgctgggtgt gcacacactc ctctcaagag ctgccatttt atgtgtctct    720

tgcactacac ctctgttgtg aggactacca ttttggagaa ggttctgttt gtctcttttc    780

attctctgcc caggttttgg gatcgcaaag ggattgttct tataaaagtg gcataaataa    840

atgcatcatt tttaggagta tagacagata tatcttattg tggggagggg aaagaaatcc    900

atctgctcat gaagcacttc tgaaaatata ggtgattgcc tgaatgtcga agactctact    960

tttgtctata aaacactata taaatgaatt ttaataaatt tttgctttag cacttggccc   1020

cattgtagat tgccctgtgc agtaaacttt caaggtgtcg gctgccccag attgcttcat   1080

ttgctgggtg tggaaagagt tgctatggcc aggcatatgg gatttggaag ctcagcagaa   1140

gtgacttctg ctctgtggtt gctgctcccc ggctttcaca gacatggtat ggcagccatt   1200

cttttatcta tttaaccaag aggatgctgg ggaattgtgc tgcttgtcct gttggctggt   1260

ggctgcatta tgtcctgggg tgtgcatgtg ggtctattta gagcttctgt cccttccttc   1320

ccattgcaag ttgcacccag atgagacagc tgtagtacta ggtctctttc acctctcatt   1380

gcctgtccct gcttcgagct ggttgtcttg tgcgtgggac atgggccttc ctatctgtgt   1440

tttctcaaag tcaggagctg accaggagca cactaaggtg tggtcatgca tcataaccaa   1500

cattcactca tctgggacat tcttaagata catttataaa tcatttcagc agtagtactt   1560

tgtatgtgtt gagagtttac agagctcttt gacatacgcg atcttagtct ttacaaataa   1620

ggaaaacagc tcagtttggg aagtatcaga gatgggattc aaacccagat cctctggtcc   1680

aagttgtatg tgcactgaac taatcaggca ggaaaaaagc ccagccactg tctcacagat   1740

tgttttttgt atattgtagc aaaatcctga aacaatgggg tccttccagt ctcatcatac   1800

aaaatggcaa tcttggctgg gtgcggtggt tcatgcctat aatcccagtg ctttacaagg   1860

ctgaggcagg aggctctctt gagaatagga gttcaagacc agcctgggca acatagcaag   1920

atcctgtctc tccaaaaaaa aaaaaaaaaa aaaaaaaaaa tttcattttt gagtccagag   1980

gaccctccta ttactcttga tttcatcttc agagtgtagt taaaaaatta ttttaaataa   2040

ttattttttt aaatcagttg taggttcaca gcaaaagtgg acaaaaagaa atttctcata   2100

tatcccctgc cctcacacat gcatagcctc ccaccactat cagtatccca caccagagtg   2160

gtacatttgt tacaatcaat aaacctccat tgacacatca ttatcaccca aagtccatag   2220

tttacatgaa gattcactct ggtgttgtac attgtatggg cttagacaaa tgtatgatga   2280

tatctacaat tatagaatca tacagaatag tttcactgcc ctaaaacttc tctatgcttc   2340

acctgttcat ccctttcttc cctaatcccc tggcaaccac tttaaaaaaa aaattaggtt   2400

cagggggtac atgtgcaggt aaactc                                        2426


<210>  7810
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  7810

Met Lys Ala Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr 
1               5                   10                  15      


Met Arg Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu 
            20                  25                  30          


Met Leu Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu 
        35                  40                  45              


Glu Glu Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala 
    50                  55                  60                  


Gly Ala Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu 
65                  70                  75                  80  


Pro Glu Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
            100                 105                 110         


<210>  7811
<211>  693
<212>  DNA
<213>  Homosapiens

<400>  7811
tgcaaagtct tgtgaagatt ccagagattc aggccaccat gagggagttg tccaaagaaa     60

tgatgaaggc tgggatcata gaggagatgt tagaggacac ttttgaaagc atggacgatc    120

aggaagaaat ggaggaagaa gcagaaatgg aaattgacag aattctcttt gaaattacag    180

caggggcctt gggcaaagca cccagtaaag tgactgatgc ccttccagag ccagaacctc    240

caggagcgat ggctgcctca gaggatgagg aggaggagga agaggctctg gaggccatgc    300

agtcccggct ggccacactc cgcagctagg ggctgcctac cccgctgggt gtgcacacac    360

tcctctcaag agctgccatt ttatgtgtct cttgcactac acctctgttg tgaggactac    420

cattttggag aaggttctgt ttgtctcttt tcattctctg cccaggtttt gggatcgcaa    480

agggattgtt cttataaaag tggcataaat aaatgcatca tttttaggag tatagacaga    540

tatatcttat tgtggggagg ggaaagaaat ccatctgctc atgaagcact tctgaaaata    600

taggtgattg cctgaatgtc gaagactcta cttttgtcta taaaacacta tataaatgaa    660

ttttaataaa tttttgcttt agcacttggc ccc                                 693


<210>  7812
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  7812

Met Arg Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu 
1               5                   10                  15      


Met Leu Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu 
            20                  25                  30          


Glu Glu Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala 
        35                  40                  45              


Gly Ala Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu 
    50                  55                  60                  


Pro Glu Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu 
65                  70                  75                  80  


Glu Glu Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
                85                  90                  95      


<210>  7813
<211>  1062
<212>  DNA
<213>  Homosapiens

<400>  7813
ggggggccgg aggaagagtc tttaggagtc ggctgtggga cgcgagagct cctggtgcca     60

tggctctcga acaggtcaat gagtggtcat tgaagataag aaaggaaatg agagttgttg    120

acaggcaaat aagggatatc caaagagaag aagaaaaagt gaaacgatct gtgaaagatg    180

ctgccaagaa gggccagaag gatgtctgca tagttctggc caaggagatg atcaggtcaa    240

ggaaggctgt gagcaagctg tatgcatcca aagcacacat gaactcagtg ctcatgggga    300

tgaagaacca gctcgcggtc ttgcgagtgg ctggttccct gcagaagagc acagaagtga    360

tgaaggccat gcaaagtctt gtgaagattc cagagattca ggccaccatg agggagttgt    420

ccaaagaaat gatgaaggct gggatcatag aggagatgtt agaggacact tttgaaagca    480

tggacgatca ggaagaaatg gaggaagaag cagaaatgga aattgacaga attctctttg    540

aaattacagc aggggccttg ggcaaagcac ccagtaaagt gactgatgcc cttccagagc    600

cagaacctcc aggagcgatg gctgcctcag aggatgagga ggaggaggaa gaggctctgg    660

aggccatgca gtcccggctg gccacactcc gcagctaggg gctgcctacc ccgctgggtg    720

tgcacacact cctctcaaga gctgccattt tatgtgtctc ttgcactaca cctctgttgt    780

gaggactacc attttggaga aggttctgtt tgtctctttt cattctctgc ccaggttttg    840

ggatcgcaaa gggattgttc ttataaaagt ggcataaata aatgcatcat ttttaggagt    900

atagacagat atatcttatt gtggggaggg gaaagaaatc catctgctca tgaagcactt    960

ctgaaaatat aggtgattgc ctgaatgtcg aagactctac ttttgtctat aaaacactat   1020

ataaatgaat tttaataaat ttttgcttta gcacttggcc cc                      1062


<210>  7814
<211>  212
<212>  PRT
<213>  Homosapiens

<400>  7814

Met Ala Leu Glu Gln Val Asn Glu Trp Ser Leu Lys Ile Arg Lys Glu 
1               5                   10                  15      


Met Arg Val Val Asp Arg Gln Ile Arg Asp Ile Gln Arg Glu Glu Glu 
            20                  25                  30          


Lys Val Lys Arg Ser Val Lys Asp Ala Ala Lys Lys Gly Gln Lys Asp 
        35                  40                  45              


Val Cys Ile Val Leu Ala Lys Glu Met Ile Arg Ser Arg Lys Ala Val 
    50                  55                  60                  


Ser Lys Leu Tyr Ala Ser Lys Ala His Met Asn Ser Val Leu Met Gly 
65                  70                  75                  80  


Met Lys Asn Gln Leu Ala Val Leu Arg Val Ala Gly Ser Leu Gln Lys 
                85                  90                  95      


Ser Thr Glu Val Met Lys Ala Met Gln Ser Leu Val Lys Ile Pro Glu 
            100                 105                 110         


Ile Gln Ala Thr Met Arg Glu Leu Ser Lys Glu Met Met Lys Ala Gly 
        115                 120                 125             


Ile Ile Glu Glu Met Leu Glu Asp Thr Phe Glu Ser Met Asp Asp Gln 
    130                 135                 140                 


Glu Glu Met Glu Glu Glu Ala Glu Met Glu Ile Asp Arg Ile Leu Phe 
145                 150                 155                 160 


Glu Ile Thr Ala Gly Ala Leu Gly Lys Ala Pro Ser Lys Val Thr Asp 
                165                 170                 175     


Ala Leu Pro Glu Pro Glu Pro Pro Gly Ala Met Ala Ala Ser Glu Asp 
            180                 185                 190         


Glu Glu Glu Glu Glu Glu Ala Leu Glu Ala Met Gln Ser Arg Leu Ala 
        195                 200                 205             


Thr Leu Arg Ser 
    210         


<210>  7815
<211>  1059
<212>  DNA
<213>  Homosapiens

<400>  7815
ccgcgggccc cgcccaggcg gctgcccgtg acctgcctgg gcgcggggaa ctgaaagccg     60

gaaggggcaa gacgggttca gttcgtcatg gggctgtttg gaaagaccca ggagaagccg    120

cccaaagaac tgatatccaa agagaagaag aaaaagtgaa acgatctgtg aaagatgctg    180

ccaagaaggg ccagaaggat gtctgcatag ttctggccaa ggagatgatc aggtcaagga    240

aggctgtgag caagctgtat gcatccaaag cacacatgaa ctcagtgctc atggggatga    300

agaaccagct cgcggtcttg cgagtggctg gttccctgca gaagagcaca gaagtgatga    360

aggccatgca aagtcttgtg aagattccag agattcaggc caccatgagg gagttgtcca    420

aagaaatgat gaaggctggg atcatagagg agatgttaga ggacactttt gaaagcatgg    480

acgatcagga agaaatggag gaagaagcag aaatggaaat tgacagaatt ctctttgaaa    540

ttacagcagg ggccttgggc aaagcaccca gtaaagtgac tgatgccctt ccagagccag    600

aacctccagg agcgatggct gcctcagagg atgaggagga ggaggaagag gctctggagg    660

ccatgcagtc ccggctggcc acactccgca gctaggggct gcctaccccg ctgggtgtgc    720

acacactcct ctcaagagct gccattttat gtgtctcttg cactacacct ctgttgtgag    780

gactaccatt ttggagaagg ttctgtttgt ctcttttcat tctctgccca ggttttggga    840

tcgcaaaggg attgttctta taaaagtggc ataaataaat gcatcatttt taggagtata    900

gacagatata tcttattgtg gggaggggaa agaaatccat ctgctcatga agcacttctg    960

aaaatatagg tgattgcctg aatgtcgaag actctacttt tgtctataaa acactatata   1020

aatgaatttt aataaatttt tgctttagca cttggcccc                          1059


<210>  7816
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  7816

Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser Lys Ala 
1               5                   10                  15      


His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala Val Leu 
            20                  25                  30          


Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys Ala Met 
        35                  40                  45              


Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg Glu Leu 
    50                  55                  60                  


Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu Glu Asp 
65                  70                  75                  80  


Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu Ala Glu 
                85                  90                  95      


Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala Leu Gly 
            100                 105                 110         


Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu Pro Pro 
        115                 120                 125             


Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu Ala Leu 
    130                 135                 140                 


Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
145                 150                 155     


<210>  7817
<211>  879
<212>  DNA
<213>  Homosapiens

<400>  7817
ccgcgggccc cgcccaggcg gctgcccgtg acctgcctgg gcgcggggaa ctgaaagccg     60

gaaggggcaa gacgggttca gttcgtcatg gggctgtttg gaaagaccca ggagaagccg    120

cccaaagaac tgcggtcttg cgagtggctg gttccctgca gaagagcaca gaagtgatga    180

aggccatgca aagtcttgtg aagattccag agattcaggc caccatgagg gagttgtcca    240

aagaaatgat gaaggctggg atcatagagg agatgttaga ggacactttt gaaagcatgg    300

acgatcagga agaaatggag gaagaagcag aaatggaaat tgacagaatt ctctttgaaa    360

ttacagcagg ggccttgggc aaagcaccca gtaaagtgac tgatgccctt ccagagccag    420

aacctccagg agcgatggct gcctcagagg atgaggagga ggaggaagag gctctggagg    480

ccatgcagtc ccggctggcc acactccgca gctaggggct gcctaccccg ctgggtgtgc    540

acacactcct ctcaagagct gccattttat gtgtctcttg cactacacct ctgttgtgag    600

gactaccatt ttggagaagg ttctgtttgt ctcttttcat tctctgccca ggttttggga    660

tcgcaaaggg attgttctta taaaagtggc ataaataaat gcatcatttt taggagtata    720

gacagatata tcttattgtg gggaggggaa agaaatccat ctgctcatga agcacttctg    780

aaaatatagg tgattgcctg aatgtcgaag actctacttt tgtctataaa acactatata    840

aatgaatttt aataaatttt tgctttagca cttggcccc                           879


<210>  7818
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  7818

Met Lys Ala Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr 
1               5                   10                  15      


Met Arg Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu 
            20                  25                  30          


Met Leu Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu 
        35                  40                  45              


Glu Glu Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala 
    50                  55                  60                  


Gly Ala Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu 
65                  70                  75                  80  


Pro Glu Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
            100                 105                 110         


<210>  7819
<211>  1021
<212>  DNA
<213>  Homosapiens

<400>  7819
cttttccgcg ggccccgccc aggcggctgc ccgtgacctg cctgggcgcg gggaactgaa     60

agccggaagg ggcaagacgg gttcagttcg tcatggggct gtttggaaag acccaggaga    120

agccgcccaa agaactgtgg agatgtgcct gcttcccctt tgccttccac catggtgtaa    180

gtttactgag gcctccccag aagcagaagc ctgtacagcc cacagaactg tgagctgatt    240

aaacctcttt tctttataaa caacccagtc tcagcggtct tgcgagtggc tggttccctg    300

cagaagagca cagaagtgat gaaggccatg caaagtcttg tgaagattcc agagattcag    360

gccaccatga gggagttgtc caaagaaatg atgaaggctg ggatcataga ggagatgtta    420

gaggacactt ttgaaagcat ggacgatcag gaagaaatgg aggaagaagc agaaatggaa    480

attgacagaa ttctctttga aattacagca ggggccttgg gcaaagcacc cagtaaagtg    540

actgatgccc ttccagagcc agaacctcca ggagcgatgg ctgcctcaga ggatgaggag    600

gaggaggaag aggctctgga ggccatgcag tcccggctgg ccacactccg cagctagggg    660

ctgcctaccc cgctgggtgt gcacacactc ctctcaagag ctgccatttt atgtgtctct    720

tgcactacac ctctgttgtg aggactacca ttttggagaa ggttctgttt gtctcttttc    780

attctctgcc caggttttgg gatcgcaaag ggattgttct tataaaagtg gcataaataa    840

atgcatcatt tttaggagta tagacagata tatcttattg tggggagggg aaagaaatcc    900

atctgctcat gaagcacttc tgaaaatata ggtgattgcc tgaatgtcga agactctact    960

tttgtctata aaacactata taaatgaatt ttaataaatt tttgctttag cacttggccc   1020

c                                                                   1021


<210>  7820
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  7820

Met Lys Ala Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr 
1               5                   10                  15      


Met Arg Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu 
            20                  25                  30          


Met Leu Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu 
        35                  40                  45              


Glu Glu Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala 
    50                  55                  60                  


Gly Ala Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu 
65                  70                  75                  80  


Pro Glu Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
            100                 105                 110         


<210>  7821
<211>  1165
<212>  DNA
<213>  Homosapiens

<400>  7821
tagtgccgcc gctccctact ctgggggttg ggactacctc cttttccgcg ggccccgccc     60

aggcggctgc ccgtgacctg cctgggcgcg gggaactgaa agccggaagg ggcaagacgg    120

gttcagttcg tcatggggct gtttggaaag acccaggaga agccgcccaa agaactggtc    180

aatgagtggt cattgaagat aagaaaggaa atgagagttg ttgacaggca aataagggat    240

atccaaagag aagaagaaaa agtgaaacga tctgtgaaag atgctgccaa gaagggccag    300

aaggatgtct gcatagttct ggccaaggag atgatcaggt caaggaaggc tgtgagcaag    360

ctgtatgcat ccaaagcaca catgaactca gtgctcatgg ggatgaagaa ccagctcgcg    420

gtcttgcgag tggctggttc cctgcagaag agcacagaag tgatgaaggc catgcaaagt    480

cttgtgaaga ttccagagat tcaggccacc atgagggagt tgtccaaaga aatgatgaag    540

gctgggatca tagaggagat gttagaggac acttttgaaa gcatggacga tcaggaagaa    600

atggaggaag aagcagaaat ggaaattgac agaattctct ttgaaattac agcaggggcc    660

ttgggcaaag cacccagtaa agtgactgat gcccttccag agccagaacc tccaggagcg    720

atggctgcct cagaggatga ggaggaggag gaagaggctc tggaggccat gcagtcccgg    780

ctggccacac tccgcagcta ggggctgcct accccgctgg gtgtgcacac actcctctca    840

agagctgcca ttttatgtgt ctcttgcact acacctctgt tgtgaggact accattttgg    900

agaaggttct gtttgtctct tttcattctc tgcccaggtt ttgggatcgc aaagggattg    960

ttcttataaa agtggcataa ataaatgcat catttttagg agtatagaca gatatatctt   1020

attgtgggga ggggaaagaa atccatctgc tcatgaagca cttctgaaaa tataggtgat   1080

tgcctgaatg tcgaagactc tacttttgtc tataaaacac tatataaatg aattttaata   1140

aatttttgct ttagcacttg gcccc                                         1165


<210>  7822
<211>  222
<212>  PRT
<213>  Homosapiens

<400>  7822

Met Gly Leu Phe Gly Lys Thr Gln Glu Lys Pro Pro Lys Glu Leu Val 
1               5                   10                  15      


Asn Glu Trp Ser Leu Lys Ile Arg Lys Glu Met Arg Val Val Asp Arg 
            20                  25                  30          


Gln Ile Arg Asp Ile Gln Arg Glu Glu Glu Lys Val Lys Arg Ser Val 
        35                  40                  45              


Lys Asp Ala Ala Lys Lys Gly Gln Lys Asp Val Cys Ile Val Leu Ala 
    50                  55                  60                  


Lys Glu Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser 
65                  70                  75                  80  


Lys Ala His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala 
                85                  90                  95      


Val Leu Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys 
            100                 105                 110         


Ala Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg 
        115                 120                 125             


Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu 
    130                 135                 140                 


Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu 
145                 150                 155                 160 


Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala 
                165                 170                 175     


Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu 
            180                 185                 190         


Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu 
        195                 200                 205             


Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
    210                 215                 220         


<210>  7823
<211>  614
<212>  DNA
<213>  Homosapiens

<400>  7823
tgcaaagtct tgtgaagatt ccagagattc aggccaccat gagggagttg tccaaagaaa     60

tgatgaaggc tgggatcata gaggagatgt tagaggacac ttttgaaagc atggacgatc    120

aggaagaaat ggaggaagaa gcagaaatgg aaattgacag aattctcttt gaaattacag    180

caggggcctt gggcaaagca cccagtaaag tgactgatgc ccttccagag ccagaacctc    240

caggagcgat ggctgcctca gaggatgagg aggaggagga agaggctctg gaggccatgc    300

agtcccggct ggccacactc cgcagctagg ggctgcctac cccgctgggt gtgcacacac    360

tcctctcaag agctgccatt ttatgtgtct cttgcactac acctctgttg tgaggactac    420

cattttggag aaggttctgt ttgtctcttt tcattctctg cccaggtttt gggatcgcaa    480

agggattgtt cttataaaag tggcataaat aaatgcatca tttttaggag tatagacaga    540

tatatcttat tgtggggagg ggaaagaaat ccatctgctc atgaagcact tctgaaaata    600

taggtgattg cctg                                                      614


<210>  7824
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  7824

Met Arg Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu 
1               5                   10                  15      


Met Leu Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu 
            20                  25                  30          


Glu Glu Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala 
        35                  40                  45              


Gly Ala Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu 
    50                  55                  60                  


Pro Glu Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu 
65                  70                  75                  80  


Glu Glu Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
                85                  90                  95      


<210>  7825
<211>  983
<212>  DNA
<213>  Homosapiens

<400>  7825
ggggggccgg aggaagagtc tttaggagtc ggctgtggga cgcgagagct cctggtgcca     60

tggctctcga acaggtcaat gagtggtcat tgaagataag aaaggaaatg agagttgttg    120

acaggcaaat aagggatatc caaagagaag aagaaaaagt gaaacgatct gtgaaagatg    180

ctgccaagaa gggccagaag gatgtctgca tagttctggc caaggagatg atcaggtcaa    240

ggaaggctgt gagcaagctg tatgcatcca aagcacacat gaactcagtg ctcatgggga    300

tgaagaacca gctcgcggtc ttgcgagtgg ctggttccct gcagaagagc acagaagtga    360

tgaaggccat gcaaagtctt gtgaagattc cagagattca ggccaccatg agggagttgt    420

ccaaagaaat gatgaaggct gggatcatag aggagatgtt agaggacact tttgaaagca    480

tggacgatca ggaagaaatg gaggaagaag cagaaatgga aattgacaga attctctttg    540

aaattacagc aggggccttg ggcaaagcac ccagtaaagt gactgatgcc cttccagagc    600

cagaacctcc aggagcgatg gctgcctcag aggatgagga ggaggaggaa gaggctctgg    660

aggccatgca gtcccggctg gccacactcc gcagctaggg gctgcctacc ccgctgggtg    720

tgcacacact cctctcaaga gctgccattt tatgtgtctc ttgcactaca cctctgttgt    780

gaggactacc attttggaga aggttctgtt tgtctctttt cattctctgc ccaggttttg    840

ggatcgcaaa gggattgttc ttataaaagt ggcataaata aatgcatcat ttttaggagt    900

atagacagat atatcttatt gtggggaggg gaaagaaatc catctgctca tgaagcactt    960

ctgaaaatat aggtgattgc ctg                                            983


<210>  7826
<211>  212
<212>  PRT
<213>  Homosapiens

<400>  7826

Met Ala Leu Glu Gln Val Asn Glu Trp Ser Leu Lys Ile Arg Lys Glu 
1               5                   10                  15      


Met Arg Val Val Asp Arg Gln Ile Arg Asp Ile Gln Arg Glu Glu Glu 
            20                  25                  30          


Lys Val Lys Arg Ser Val Lys Asp Ala Ala Lys Lys Gly Gln Lys Asp 
        35                  40                  45              


Val Cys Ile Val Leu Ala Lys Glu Met Ile Arg Ser Arg Lys Ala Val 
    50                  55                  60                  


Ser Lys Leu Tyr Ala Ser Lys Ala His Met Asn Ser Val Leu Met Gly 
65                  70                  75                  80  


Met Lys Asn Gln Leu Ala Val Leu Arg Val Ala Gly Ser Leu Gln Lys 
                85                  90                  95      


Ser Thr Glu Val Met Lys Ala Met Gln Ser Leu Val Lys Ile Pro Glu 
            100                 105                 110         


Ile Gln Ala Thr Met Arg Glu Leu Ser Lys Glu Met Met Lys Ala Gly 
        115                 120                 125             


Ile Ile Glu Glu Met Leu Glu Asp Thr Phe Glu Ser Met Asp Asp Gln 
    130                 135                 140                 


Glu Glu Met Glu Glu Glu Ala Glu Met Glu Ile Asp Arg Ile Leu Phe 
145                 150                 155                 160 


Glu Ile Thr Ala Gly Ala Leu Gly Lys Ala Pro Ser Lys Val Thr Asp 
                165                 170                 175     


Ala Leu Pro Glu Pro Glu Pro Pro Gly Ala Met Ala Ala Ser Glu Asp 
            180                 185                 190         


Glu Glu Glu Glu Glu Glu Ala Leu Glu Ala Met Gln Ser Arg Leu Ala 
        195                 200                 205             


Thr Leu Arg Ser 
    210         


<210>  7827
<211>  980
<212>  DNA
<213>  Homosapiens

<400>  7827
ccgcgggccc cgcccaggcg gctgcccgtg acctgcctgg gcgcggggaa ctgaaagccg     60

gaaggggcaa gacgggttca gttcgtcatg gggctgtttg gaaagaccca ggagaagccg    120

cccaaagaac tgatatccaa agagaagaag aaaaagtgaa acgatctgtg aaagatgctg    180

ccaagaaggg ccagaaggat gtctgcatag ttctggccaa ggagatgatc aggtcaagga    240

aggctgtgag caagctgtat gcatccaaag cacacatgaa ctcagtgctc atggggatga    300

agaaccagct cgcggtcttg cgagtggctg gttccctgca gaagagcaca gaagtgatga    360

aggccatgca aagtcttgtg aagattccag agattcaggc caccatgagg gagttgtcca    420

aagaaatgat gaaggctggg atcatagagg agatgttaga ggacactttt gaaagcatgg    480

acgatcagga agaaatggag gaagaagcag aaatggaaat tgacagaatt ctctttgaaa    540

ttacagcagg ggccttgggc aaagcaccca gtaaagtgac tgatgccctt ccagagccag    600

aacctccagg agcgatggct gcctcagagg atgaggagga ggaggaagag gctctggagg    660

ccatgcagtc ccggctggcc acactccgca gctaggggct gcctaccccg ctgggtgtgc    720

acacactcct ctcaagagct gccattttat gtgtctcttg cactacacct ctgttgtgag    780

gactaccatt ttggagaagg ttctgtttgt ctcttttcat tctctgccca ggttttggga    840

tcgcaaaggg attgttctta taaaagtggc ataaataaat gcatcatttt taggagtata    900

gacagatata tcttattgtg gggaggggaa agaaatccat ctgctcatga agcacttctg    960

aaaatatagg tgattgcctg                                                980


<210>  7828
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  7828

Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser Lys Ala 
1               5                   10                  15      


His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala Val Leu 
            20                  25                  30          


Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys Ala Met 
        35                  40                  45              


Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg Glu Leu 
    50                  55                  60                  


Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu Glu Asp 
65                  70                  75                  80  


Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu Ala Glu 
                85                  90                  95      


Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala Leu Gly 
            100                 105                 110         


Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu Pro Pro 
        115                 120                 125             


Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu Ala Leu 
    130                 135                 140                 


Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
145                 150                 155     


<210>  7829
<211>  942
<212>  DNA
<213>  Homosapiens

<400>  7829
cttttccgcg ggccccgccc aggcggctgc ccgtgacctg cctgggcgcg gggaactgaa     60

agccggaagg ggcaagacgg gttcagttcg tcatggggct gtttggaaag acccaggaga    120

agccgcccaa agaactgtgg agatgtgcct gcttcccctt tgccttccac catggtgtaa    180

gtttactgag gcctccccag aagcagaagc ctgtacagcc cacagaactg tgagctgatt    240

aaacctcttt tctttataaa caacccagtc tcagcggtct tgcgagtggc tggttccctg    300

cagaagagca cagaagtgat gaaggccatg caaagtcttg tgaagattcc agagattcag    360

gccaccatga gggagttgtc caaagaaatg atgaaggctg ggatcataga ggagatgtta    420

gaggacactt ttgaaagcat ggacgatcag gaagaaatgg aggaagaagc agaaatggaa    480

attgacagaa ttctctttga aattacagca ggggccttgg gcaaagcacc cagtaaagtg    540

actgatgccc ttccagagcc agaacctcca ggagcgatgg ctgcctcaga ggatgaggag    600

gaggaggaag aggctctgga ggccatgcag tcccggctgg ccacactccg cagctagggg    660

ctgcctaccc cgctgggtgt gcacacactc ctctcaagag ctgccatttt atgtgtctct    720

tgcactacac ctctgttgtg aggactacca ttttggagaa ggttctgttt gtctcttttc    780

attctctgcc caggttttgg gatcgcaaag ggattgttct tataaaagtg gcataaataa    840

atgcatcatt tttaggagta tagacagata tatcttattg tggggagggg aaagaaatcc    900

atctgctcat gaagcacttc tgaaaatata ggtgattgcc tg                       942


<210>  7830
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  7830

Met Lys Ala Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr 
1               5                   10                  15      


Met Arg Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu 
            20                  25                  30          


Met Leu Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu 
        35                  40                  45              


Glu Glu Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala 
    50                  55                  60                  


Gly Ala Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu 
65                  70                  75                  80  


Pro Glu Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
            100                 105                 110         


<210>  7831
<211>  1086
<212>  DNA
<213>  Homosapiens

<400>  7831
tagtgccgcc gctccctact ctgggggttg ggactacctc cttttccgcg ggccccgccc     60

aggcggctgc ccgtgacctg cctgggcgcg gggaactgaa agccggaagg ggcaagacgg    120

gttcagttcg tcatggggct gtttggaaag acccaggaga agccgcccaa agaactggtc    180

aatgagtggt cattgaagat aagaaaggaa atgagagttg ttgacaggca aataagggat    240

atccaaagag aagaagaaaa agtgaaacga tctgtgaaag atgctgccaa gaagggccag    300

aaggatgtct gcatagttct ggccaaggag atgatcaggt caaggaaggc tgtgagcaag    360

ctgtatgcat ccaaagcaca catgaactca gtgctcatgg ggatgaagaa ccagctcgcg    420

gtcttgcgag tggctggttc cctgcagaag agcacagaag tgatgaaggc catgcaaagt    480

cttgtgaaga ttccagagat tcaggccacc atgagggagt tgtccaaaga aatgatgaag    540

gctgggatca tagaggagat gttagaggac acttttgaaa gcatggacga tcaggaagaa    600

atggaggaag aagcagaaat ggaaattgac agaattctct ttgaaattac agcaggggcc    660

ttgggcaaag cacccagtaa agtgactgat gcccttccag agccagaacc tccaggagcg    720

atggctgcct cagaggatga ggaggaggag gaagaggctc tggaggccat gcagtcccgg    780

ctggccacac tccgcagcta ggggctgcct accccgctgg gtgtgcacac actcctctca    840

agagctgcca ttttatgtgt ctcttgcact acacctctgt tgtgaggact accattttgg    900

agaaggttct gtttgtctct tttcattctc tgcccaggtt ttgggatcgc aaagggattg    960

ttcttataaa agtggcataa ataaatgcat catttttagg agtatagaca gatatatctt   1020

attgtgggga ggggaaagaa atccatctgc tcatgaagca cttctgaaaa tataggtgat   1080

tgcctg                                                              1086


<210>  7832
<211>  222
<212>  PRT
<213>  Homosapiens

<400>  7832

Met Gly Leu Phe Gly Lys Thr Gln Glu Lys Pro Pro Lys Glu Leu Val 
1               5                   10                  15      


Asn Glu Trp Ser Leu Lys Ile Arg Lys Glu Met Arg Val Val Asp Arg 
            20                  25                  30          


Gln Ile Arg Asp Ile Gln Arg Glu Glu Glu Lys Val Lys Arg Ser Val 
        35                  40                  45              


Lys Asp Ala Ala Lys Lys Gly Gln Lys Asp Val Cys Ile Val Leu Ala 
    50                  55                  60                  


Lys Glu Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser 
65                  70                  75                  80  


Lys Ala His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala 
                85                  90                  95      


Val Leu Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys 
            100                 105                 110         


Ala Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg 
        115                 120                 125             


Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu 
    130                 135                 140                 


Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu 
145                 150                 155                 160 


Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala 
                165                 170                 175     


Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu 
            180                 185                 190         


Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu 
        195                 200                 205             


Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
    210                 215                 220         


<210>  7833
<211>  536
<212>  DNA
<213>  Homosapiens

<400>  7833
ccatgcaaag tcttgtgaag attccagaga ttcaggccac catgagggag ttgtccaaag     60

aaatgatgaa ggctgggatc atagaggaga tgttagagga cacttttgaa agcatggacg    120

atcaggaaga aatggaggaa gaagcagaaa tggaaattga cagaattctc tttgaaatta    180

cagcaggggc cttgggcaaa gcacccagta aagtgactga tgcccttcca gagccagaac    240

ctccaggagc gatggctgcc tcagaggatg aggaggagga ggaagaggct ctggaggcca    300

tgcagtcccg gctggccaca ctccgcagct aggggctgcc taccccgctg ggtgtgcaca    360

cactcctctc aagagctgcc attttatgtg tctcttgcac tacacctctg ttgtgaggac    420

taccattttg gagaaggttc tgtttgtctc ttttcattct ctgcccaggt tttgggatcg    480

caaagggatt gttcttataa aagtggcata aataaatgca tcatttttag gagtat        536


<210>  7834
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  7834

Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg Glu 
1               5                   10                  15      


Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu Glu 
            20                  25                  30          


Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu Ala 
        35                  40                  45              


Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala Leu 
    50                  55                  60                  


Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu Pro 
65                  70                  75                  80  


Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu Ala 
                85                  90                  95      


Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
            100                 105                 


<210>  7835
<211>  902
<212>  DNA
<213>  Homosapiens

<400>  7835
ggggggccgg aggaagagtc tttaggagtc ggctgtggga cgcgagagct cctggtgcca     60

tggctctcga acaggtcaat gagtggtcat tgaagataag aaaggaaatg agagttgttg    120

acaggcaaat aagggatatc caaagagaag aagaaaaagt gaaacgatct gtgaaagatg    180

ctgccaagaa gggccagaag gatgtctgca tagttctggc caaggagatg atcaggtcaa    240

ggaaggctgt gagcaagctg tatgcatcca aagcacacat gaactcagtg ctcatgggga    300

tgaagaacca gctcgcggtc ttgcgagtgg ctggttccct gcagaagagc acagaagtga    360

tgaaggccat gcaaagtctt gtgaagattc cagagattca ggccaccatg agggagttgt    420

ccaaagaaat gatgaaggct gggatcatag aggagatgtt agaggacact tttgaaagca    480

tggacgatca ggaagaaatg gaggaagaag cagaaatgga aattgacaga attctctttg    540

aaattacagc aggggccttg ggcaaagcac ccagtaaagt gactgatgcc cttccagagc    600

cagaacctcc aggagcgatg gctgcctcag aggatgagga ggaggaggaa gaggctctgg    660

aggccatgca gtcccggctg gccacactcc gcagctaggg gctgcctacc ccgctgggtg    720

tgcacacact cctctcaaga gctgccattt tatgtgtctc ttgcactaca cctctgttgt    780

gaggactacc attttggaga aggttctgtt tgtctctttt cattctctgc ccaggttttg    840

ggatcgcaaa gggattgttc ttataaaagt ggcataaata aatgcatcat ttttaggagt    900

at                                                                   902


<210>  7836
<211>  212
<212>  PRT
<213>  Homosapiens

<400>  7836

Met Ala Leu Glu Gln Val Asn Glu Trp Ser Leu Lys Ile Arg Lys Glu 
1               5                   10                  15      


Met Arg Val Val Asp Arg Gln Ile Arg Asp Ile Gln Arg Glu Glu Glu 
            20                  25                  30          


Lys Val Lys Arg Ser Val Lys Asp Ala Ala Lys Lys Gly Gln Lys Asp 
        35                  40                  45              


Val Cys Ile Val Leu Ala Lys Glu Met Ile Arg Ser Arg Lys Ala Val 
    50                  55                  60                  


Ser Lys Leu Tyr Ala Ser Lys Ala His Met Asn Ser Val Leu Met Gly 
65                  70                  75                  80  


Met Lys Asn Gln Leu Ala Val Leu Arg Val Ala Gly Ser Leu Gln Lys 
                85                  90                  95      


Ser Thr Glu Val Met Lys Ala Met Gln Ser Leu Val Lys Ile Pro Glu 
            100                 105                 110         


Ile Gln Ala Thr Met Arg Glu Leu Ser Lys Glu Met Met Lys Ala Gly 
        115                 120                 125             


Ile Ile Glu Glu Met Leu Glu Asp Thr Phe Glu Ser Met Asp Asp Gln 
    130                 135                 140                 


Glu Glu Met Glu Glu Glu Ala Glu Met Glu Ile Asp Arg Ile Leu Phe 
145                 150                 155                 160 


Glu Ile Thr Ala Gly Ala Leu Gly Lys Ala Pro Ser Lys Val Thr Asp 
                165                 170                 175     


Ala Leu Pro Glu Pro Glu Pro Pro Gly Ala Met Ala Ala Ser Glu Asp 
            180                 185                 190         


Glu Glu Glu Glu Glu Glu Ala Leu Glu Ala Met Gln Ser Arg Leu Ala 
        195                 200                 205             


Thr Leu Arg Ser 
    210         


<210>  7837
<211>  899
<212>  DNA
<213>  Homosapiens

<400>  7837
ccgcgggccc cgcccaggcg gctgcccgtg acctgcctgg gcgcggggaa ctgaaagccg     60

gaaggggcaa gacgggttca gttcgtcatg gggctgtttg gaaagaccca ggagaagccg    120

cccaaagaac tgatatccaa agagaagaag aaaaagtgaa acgatctgtg aaagatgctg    180

ccaagaaggg ccagaaggat gtctgcatag ttctggccaa ggagatgatc aggtcaagga    240

aggctgtgag caagctgtat gcatccaaag cacacatgaa ctcagtgctc atggggatga    300

agaaccagct cgcggtcttg cgagtggctg gttccctgca gaagagcaca gaagtgatga    360

aggccatgca aagtcttgtg aagattccag agattcaggc caccatgagg gagttgtcca    420

aagaaatgat gaaggctggg atcatagagg agatgttaga ggacactttt gaaagcatgg    480

acgatcagga agaaatggag gaagaagcag aaatggaaat tgacagaatt ctctttgaaa    540

ttacagcagg ggccttgggc aaagcaccca gtaaagtgac tgatgccctt ccagagccag    600

aacctccagg agcgatggct gcctcagagg atgaggagga ggaggaagag gctctggagg    660

ccatgcagtc ccggctggcc acactccgca gctaggggct gcctaccccg ctgggtgtgc    720

acacactcct ctcaagagct gccattttat gtgtctcttg cactacacct ctgttgtgag    780

gactaccatt ttggagaagg ttctgtttgt ctcttttcat tctctgccca ggttttggga    840

tcgcaaaggg attgttctta taaaagtggc ataaataaat gcatcatttt taggagtat     899


<210>  7838
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  7838

Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser Lys Ala 
1               5                   10                  15      


His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala Val Leu 
            20                  25                  30          


Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys Ala Met 
        35                  40                  45              


Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg Glu Leu 
    50                  55                  60                  


Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu Glu Asp 
65                  70                  75                  80  


Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu Ala Glu 
                85                  90                  95      


Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala Leu Gly 
            100                 105                 110         


Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu Pro Pro 
        115                 120                 125             


Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu Ala Leu 
    130                 135                 140                 


Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
145                 150                 155     


<210>  7839
<211>  861
<212>  DNA
<213>  Homosapiens

<400>  7839
cttttccgcg ggccccgccc aggcggctgc ccgtgacctg cctgggcgcg gggaactgaa     60

agccggaagg ggcaagacgg gttcagttcg tcatggggct gtttggaaag acccaggaga    120

agccgcccaa agaactgtgg agatgtgcct gcttcccctt tgccttccac catggtgtaa    180

gtttactgag gcctccccag aagcagaagc ctgtacagcc cacagaactg tgagctgatt    240

aaacctcttt tctttataaa caacccagtc tcagcggtct tgcgagtggc tggttccctg    300

cagaagagca cagaagtgat gaaggccatg caaagtcttg tgaagattcc agagattcag    360

gccaccatga gggagttgtc caaagaaatg atgaaggctg ggatcataga ggagatgtta    420

gaggacactt ttgaaagcat ggacgatcag gaagaaatgg aggaagaagc agaaatggaa    480

attgacagaa ttctctttga aattacagca ggggccttgg gcaaagcacc cagtaaagtg    540

actgatgccc ttccagagcc agaacctcca ggagcgatgg ctgcctcaga ggatgaggag    600

gaggaggaag aggctctgga ggccatgcag tcccggctgg ccacactccg cagctagggg    660

ctgcctaccc cgctgggtgt gcacacactc ctctcaagag ctgccatttt atgtgtctct    720

tgcactacac ctctgttgtg aggactacca ttttggagaa ggttctgttt gtctcttttc    780

attctctgcc caggttttgg gatcgcaaag ggattgttct tataaaagtg gcataaataa    840

atgcatcatt tttaggagta t                                              861


<210>  7840
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  7840

Met Lys Ala Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr 
1               5                   10                  15      


Met Arg Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu 
            20                  25                  30          


Met Leu Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu 
        35                  40                  45              


Glu Glu Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala 
    50                  55                  60                  


Gly Ala Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu 
65                  70                  75                  80  


Pro Glu Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
            100                 105                 110         


<210>  7841
<211>  1005
<212>  DNA
<213>  Homosapiens

<400>  7841
tagtgccgcc gctccctact ctgggggttg ggactacctc cttttccgcg ggccccgccc     60

aggcggctgc ccgtgacctg cctgggcgcg gggaactgaa agccggaagg ggcaagacgg    120

gttcagttcg tcatggggct gtttggaaag acccaggaga agccgcccaa agaactggtc    180

aatgagtggt cattgaagat aagaaaggaa atgagagttg ttgacaggca aataagggat    240

atccaaagag aagaagaaaa agtgaaacga tctgtgaaag atgctgccaa gaagggccag    300

aaggatgtct gcatagttct ggccaaggag atgatcaggt caaggaaggc tgtgagcaag    360

ctgtatgcat ccaaagcaca catgaactca gtgctcatgg ggatgaagaa ccagctcgcg    420

gtcttgcgag tggctggttc cctgcagaag agcacagaag tgatgaaggc catgcaaagt    480

cttgtgaaga ttccagagat tcaggccacc atgagggagt tgtccaaaga aatgatgaag    540

gctgggatca tagaggagat gttagaggac acttttgaaa gcatggacga tcaggaagaa    600

atggaggaag aagcagaaat ggaaattgac agaattctct ttgaaattac agcaggggcc    660

ttgggcaaag cacccagtaa agtgactgat gcccttccag agccagaacc tccaggagcg    720

atggctgcct cagaggatga ggaggaggag gaagaggctc tggaggccat gcagtcccgg    780

ctggccacac tccgcagcta ggggctgcct accccgctgg gtgtgcacac actcctctca    840

agagctgcca ttttatgtgt ctcttgcact acacctctgt tgtgaggact accattttgg    900

agaaggttct gtttgtctct tttcattctc tgcccaggtt ttgggatcgc aaagggattg    960

ttcttataaa agtggcataa ataaatgcat catttttagg agtat                   1005


<210>  7842
<211>  222
<212>  PRT
<213>  Homosapiens

<400>  7842

Met Gly Leu Phe Gly Lys Thr Gln Glu Lys Pro Pro Lys Glu Leu Val 
1               5                   10                  15      


Asn Glu Trp Ser Leu Lys Ile Arg Lys Glu Met Arg Val Val Asp Arg 
            20                  25                  30          


Gln Ile Arg Asp Ile Gln Arg Glu Glu Glu Lys Val Lys Arg Ser Val 
        35                  40                  45              


Lys Asp Ala Ala Lys Lys Gly Gln Lys Asp Val Cys Ile Val Leu Ala 
    50                  55                  60                  


Lys Glu Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser 
65                  70                  75                  80  


Lys Ala His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala 
                85                  90                  95      


Val Leu Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys 
            100                 105                 110         


Ala Met Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg 
        115                 120                 125             


Glu Leu Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu 
    130                 135                 140                 


Glu Asp Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu 
145                 150                 155                 160 


Ala Glu Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala 
                165                 170                 175     


Leu Gly Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu 
            180                 185                 190         


Pro Pro Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu 
        195                 200                 205             


Ala Leu Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
    210                 215                 220         


<210>  7843
<211>  2724
<212>  DNA
<213>  Homosapiens

<400>  7843
ctgccacacc ttttttcgtt tttccttttg gaacatagga aatacatttt ttaaatacct     60

gtcttagttt cttttgtgct gctatagcag aatacctgag actgagtaat ttattcagag    120

tagaatttta tttcatgcag ttctggagtc tgggaagttc aagattaagg tgctggcagg    180

gttggttgtc tggtgagggc tgcattttct ggagggtagg catgctgtgt tctcacgtgg    240

caggaggaag ggcaacggag aacgaactgc ctcctgtagg cccttttcta agggcaccta    300

atccattcag gagggtggaa cctcatggcc taatcacctc ttaaaaactc cacctcttaa    360

tacttatcac agtggcaaca cctgaatttt ggagaggacg tattcaaacc atagcaacca    420

cctttgtctt gagtttcaag tgtacaacat acaattagtc tggcctttta aaaatccact    480

tacctaatcc attttggttg gttatcaact tgagtgtttt tgtaataagt tttatttcta    540

agtttatttt tgtgtcccct ttttcctaca acattgactc ttcccttctt gtaccttcta    600

ataatcagaa atttatacct ttttcagaat acaaatgatt cagtgtttaa atacttctct    660

agtcacagtt ttttccatgt ctcccatctg tttacttatt ttcactaatt cagcccaaaa    720

atgtttactg aacacatacc atgttcaggt actctctctg ggttacagac tcaggatgca    780

aataataata caacttataa tatgtataag gatgtatcag gatgcaaatt ataaaataat    840

aatacaacta caggctcatg tagacatcag gctttataaa caaaactgga tggaatttgc    900

tttattttta cccttttctt cccaccttta tataatcaat agtaattttt aactttttat    960

aaaattataa aattttataa atttataaaa gtaaatttat aaaagtaatt ataacttttt   1020

tatcatttta atggcatatg taatttattg cttatttcag cctcacagat tcttggcact   1080

tcctctgtca ttctactaat attaataaat attttatttt cccatttcag tgttaagaga   1140

aatgaagtgt tctctgcaac tagcaaactc ccttactcct ttagaaaaat cacagtgcta   1200

tgaatgtcag acaggcattt ctctggtcac tcttgttttc ccttagatgt gaaagcttcc   1260

tagggtctgg attccaccag aagtaaacct gtagtgactc ctggtttagc caggaggaag   1320

gaagtctgtg tgccggtttt agggaacagc ttgtatatga cagctctcag aacttcaagt   1380

ctcatgaaat tccaaaacag gtttagatgg ttgccaactc tttgacatgt taaagacatt   1440

gagggtgggg caatgatctt ttgatactac cgtgatttct tataaagaag attgtagtag   1500

gcatacaatc tcagactaca gaaggttttt ctctagtaag gaaccacctc acattgacac   1560

acatacacat attcactgta tctgtcctag tttctctcat ttttctgagg accaatgata   1620

agctggctcc atactgaaca gatactgtcc ataggctggt gtgtggggag ctctgctcgg   1680

gtcctgaagc cttctctttc ctagtgtggc ctttacaagg tctggagctc tttctcccat   1740

ttgtgatttt cctgggtgtc acagttactc caagctggct tcctttccta aaagtcaaga   1800

gtggcttcag gccactctcc agattggtca tgtggtgtgc atgctcattg aattcacatc   1860

agtagtaacc cagatagcat acaatttagg aaagtcaatc tcttggtcaa ctagcacagt   1920

aattaattta aaggcacaca aataacttcg ggagtccatc tgctactgct gtcatttatt   1980

ggaatggctc ataatttggc tgtctctctc tattccatcc tgttgaacaa tcctgactgt   2040

acacattctc tttcagcggt cttgcgagtg gctggttccc tgcagaagag cacagaagtg   2100

atgaaggcca tgcaaagtct tgtgaagatt ccagagattc aggccaccat gagggagttg   2160

tccaaagaaa tgatgaaggc tgggatcata gaggagatgt tagaggacac ttttgaaagc   2220

atggacgatc aggaagaaat ggaggaagaa gcagaaatgg aaattgacag aattctcttt   2280

gaaattacag caggtatgac cgtgagatcc atcctttctc ctctcttttt atggccattc   2340

ttccttcatt cactaaatta gctagtagct ttttctttag gcattaactc ccttctacat   2400

ttttaacgtt ttacactgtg cagcttattt cttgaaaagt aagcacaata tctataacca   2460

tcttttaaaa aacacaattc ttaaaatttt tagagtttgc atgattttaa aggaagatac   2520

tgctctcata tactgctgtt gggattttaa actggtgtag actttcttga aagcaatttg   2580

gccatagcca ttcaaaagcc cttgccttcg ccaagtgcga tggctcacgc ctgttatccc   2640

agcactttgg gaggctcagg tgggggatcg cttgagccca ggagtttgag accagcctgg   2700

gcaaccatag caagaccgca tctc                                          2724


<210>  7844
<211>  125
<212>  PRT
<213>  Homosapiens

<400>  7844

Met Ala His Asn Leu Ala Val Ser Leu Tyr Ser Ile Leu Leu Asn Asn 
1               5                   10                  15      


Pro Asp Cys Thr His Ser Leu Ser Ala Val Leu Arg Val Ala Gly Ser 
            20                  25                  30          


Leu Gln Lys Ser Thr Glu Val Met Lys Ala Met Gln Ser Leu Val Lys 
        35                  40                  45              


Ile Pro Glu Ile Gln Ala Thr Met Arg Glu Leu Ser Lys Glu Met Met 
    50                  55                  60                  


Lys Ala Gly Ile Ile Glu Glu Met Leu Glu Asp Thr Phe Glu Ser Met 
65                  70                  75                  80  


Asp Asp Gln Glu Glu Met Glu Glu Glu Ala Glu Met Glu Ile Asp Arg 
                85                  90                  95      


Ile Leu Phe Glu Ile Thr Ala Gly Met Thr Val Arg Ser Ile Leu Ser 
            100                 105                 110         


Pro Leu Phe Leu Trp Pro Phe Phe Leu His Ser Leu Asn 
        115                 120                 125 


<210>  7845
<211>  898
<212>  DNA
<213>  Homosapiens

<400>  7845
ccgcgggccc cgcccaggcg gctgcccgtg acctgcctgg gcgcggggaa ctgaaagccg     60

gaaggggcaa gacgggttca gttcgtcatg gggctgtttg gaaagaccca ggagaagccg    120

cccaaagaac tggtcaatga gtggtcattg aagataagaa aggaaatgag agttgttgac    180

aggcaaataa ggggatccat tggagtcttt ggctgaatac taagctgtgc atgcttagag    240

tgaaatttca agagactggg caaagaacaa ttactaggaa cagaacaact accaggaagc    300

tgtaagctga ataattctta gagctaataa aggattgaga agtggttgag ctctgatcag    360

acacagaaaa gagactttgt tgaacctctg ggatgttcaa tagagacctc agaagagtca    420

caccttaata ataaggatca ggtaggtagt cctagaaaaa aggctaccac aagcccatac    480

caaccaacca acaagactta aaagacttca cggctgattt gcaggtaatt tgactgcctg    540

ccaaagtaaa gattaacact gtttaaggga agactacaaa atgcaggcac ccaacaatga    600

aacatataca gtggccagca tccaataaga tactattatg aagaagcagg aaaatgtgac    660

cccaaaacag gagaaaagcc aggtaataga aatagattta aaaaaaaaaa acacccaaaa    720

cccccacaaa aaaagatgat tgaatttgca gtcaaggatt tttaagcagc tattataaat    780

atgttgagat taaaggataa cttaaacata atgaggagat aaatacaaaa tacagaaaac    840

aacaaaatgg aatttctaga gttgaaagat ctgaaatgaa gtgaaattaa atgaagaa      898


<210>  7846
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  7846

Met Gly Leu Phe Gly Lys Thr Gln Glu Lys Pro Pro Lys Glu Leu Val 
1               5                   10                  15      


Asn Glu Trp Ser Leu Lys Ile Arg Lys Glu Met Arg Val Val Asp Arg 
            20                  25                  30          


Gln Ile Arg Gly Ser Ile Gly Val Phe Gly 
        35                  40          


<210>  7847
<211>  507
<212>  DNA
<213>  Homosapiens

<400>  7847
accaaggagc aaaactgagt aagtttcctg acgaaaataa tgagtgtcta ctgttctagg     60

gcctttaaca acaacaacaa caaatttaca ttaacgcaca ttatgtgcca ggaattgcaa    120

gatgcataag attagttttt aaaatgtgcc tgctagagct gaacaggtaa cgagagttcg    180

aagccgggtc cagagctatc ttctgtaaca ttcttctggg tcgagtccct gccccgctac    240

gagactatac gtaacatgga cctggaaaag cttaaaaata tgaagaggat tgaactggct    300

gccatctgtg catcttcatt tatgaaaaca ctcctcatag acttaaaaca aatgacagag    360

aacaaattag tcagcttctt ctaaaataca gtggtctccc cttaccctca gtttcacttt    420

ctgcagtcaa ctgcagtccg aaaatactac atacaattag atattcggag agagagacac    480

cacatttaca taaatgttat ttcagta                                        507


<210>  7848
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  7848

Met Asp Leu Glu Lys Leu Lys Asn Met Lys Arg Ile Glu Leu Ala Ala 
1               5                   10                  15      


Ile Cys Ala Ser Ser Phe Met Lys Thr Leu Leu Ile Asp Leu Lys Gln 
            20                  25                  30          


Met Thr Glu Asn Lys Leu Val Ser Phe Phe 
        35                  40          


<210>  7849
<211>  4583
<212>  DNA
<213>  Homosapiens

<400>  7849
tcttgagtgg tagcaataaa aataaaataa aataaagaac aagaggcaat aggcgcctgc     60

tttgcttgat cttcctaatt ttctaggtac aacttttttt tctctctttt ttttgagatg    120

gagtcttgct ctgttaccca ggctggagtg cagtggcata atctcggctc actgcaacct    180

ctgcttccca ggttcaagcg attctgctgc ctcagcctcc caagtagcta ggattacagg    240

tgtgcaccac cacgcccggc aaatttttgt tttttttaat agaggcgggg tttcgccatg    300

ttggccaggc tggtcttgaa ctcctgacct caaatgatcc accagcctca gcctccaaaa    360

gtgctgggat taaaggcatg agccactgta cctggccttc taggtaaaac ttataaagta    420

cttttggacc agagaaaaat gtaaagctag ggacttactg ggtagggaaa cgtgtgagca    480

tccttcaaaa gagctttcac ctattaagtg catgtcccca gattgccttc ttcctggtta    540

cttcagctgt ctgagtattt gaataaattg tatctgcctc aataagacca cttattttca    600

ttaaaaagta ctatcaaaac catggttggg tgcagtggtt catgcctgta attccaacac    660

ttgggaggcc gaggcagaag gaaccctgag gccaggtatt tgaggctgca gtgagccatg    720

attgagccat tgcacttcag cctggggaac agagtgagac cctgtccctt aaaaaaaaat    780

gtaatatcaa aaccatttgc ttaatgccct aaattgtgta tatgtattca ttaagcttca    840

aacttatgtg ataagatgtt atgtatgcac gtgtgtctcg gtaagtatga ggatggtagt    900

ggagtgtcac agaggttatt tggcacataa agtgaacttc aagtcacttg tcatcacaat    960

gtgctgtttc ttctgctgcc ctctgacatt tgttagacgt tctagcacag aggccacaga   1020

tgaggtggct gcaccacctc ttgcgtctcc caaggagttg actgtcagca ctcattttac   1080

acacccacct gcaacttcac ttcctggagg ctttgtgagt gtgaaaatgg tccttcctcc   1140

cagaaagagt agaggccccc agagtattat gttgtaattt tgaattgtat agtatcagaa   1200

atataacatt tatgaaaata aacttggcct atataccctg gacttaaaca gatggtttca   1260

tgatgacttt agacattttt ggctttcctt taacttccca tttagttatt tttatggtct   1320

tgtttttaat gttttttggt ttttactggt atctgcattg aaattctgcc ttcattaaag   1380

gcaggaagat taggagataa agggaaaagg tggtaatgat tagaaaggct gacacttata   1440

agagaagtct tgacatattt tgaaggtctt gctctgtcac ccaggctgga ttgcagtggt   1500

gcaacctcta ctcactgcaa cctccacctc acaggttcaa gtgattctca tgcttcagcc   1560

ttctgagcag ctgggactat aggtgcctgc caccatgcct ggctaatttt tgtatttcta   1620

gtagagacgg ggttttgcca tgttggccag gctggtcttg aactcttcga ctcaagtgat   1680

gcatctgcct cggcctccca acatgttggg attacaggcg tgagccacca cacctggcct   1740

ctttttcttt tcttaagaat cttttgcttt tcctaatcct aattgtgttt gaaagctctt   1800

gcaaatttga agtacaagtt caataatgta aaattcatta cattaaagaa tgaataagaa   1860

gaatggtaat tcttattgta tgttagagcc gttcatgatt aagcaaaaag ccatagaact   1920

agtagtattt attgatttag tcaaagcacc ctttaataga aaacatgtgt ttgactcttg   1980

gctccataat tatacttttt aaaaagtgaa atttgaactt gttgaaccta catgtgataa   2040

tttttagtaa gctctatttg gattattgtt taaaattttc ttttcagagc aaagagaaat   2100

tattccaagg gccattttct tcctgtgtaa cttaattaga gagaagaggc cacatggtgg   2160

agaatgtggc tagcctttta atacagtttt gactccctcc ctctctttgt aactgccaca   2220

gagtgtggga gagtttaatt tacgtttcag tgtttcaagt ctttttccta ttggatagtt   2280

gctccttcta taagaattgt aatgataatg tgatgataca gtaaacaaga actgggaaca   2340

gaatatcttt ttttttaagt gaaattatat tgttgatgta aacggttggc ttgactccat   2400

tttaggtaat tcaagtttct ttttctctat ttttgggaat aggtcatagc aaatgacaga   2460

agtcccttgg tgggcaaaat tcactgggag aaaatggtta aaaaggtgtc aagatttgga   2520

atacgtacag gcacatttaa ctgttccagt gatcccagat attgcaggag aagaggctgg   2580

gtccgatcca cactcattat gtctgttcca caaacaagta cttcaaaagg gaaagtcatg   2640

cttaaagaat acagtggacg caagattgaa gtagagcaca tttttaaatg gataactgct   2700

catgcagctt ctcggatcaa aaccatttat aatgctgaac acttgaaaga agaatggaat   2760

aaaagtgatc agtattggtt aaaaatatac ctatttgcaa accttgacca gcccccagct   2820

ttcttctctg cactaagtat aaagtttact ggaagagttg agtttatttt tgttaatgta   2880

gaaaattggg acaacaagag ttatatgaca gatattggca tatataatat gccatcatac   2940

atacttagaa ctcctgaagg aatttacagg tatggaaacc acacaggcga atttatatcc   3000

cttcaggcca tggattcatt tttgcgctca ttacaacccg aggtaaatga tctgtttgtt   3060

ttgagcttgg ttctagttaa tcttatggct tggatggact tatttattac acaaggagct   3120

accataaagc gatttgtggt tctcataagc actttaggga catataattc tctattaatt   3180

atttcctggc tacctgtgtt gggcttttta cagctacctt acttagatag cttttatgaa   3240

tatagcttaa aattgttgag atattccaat acaaccacac tggcttcatg ggtaagggca   3300

gactggatgt tttactcttc acacccagcc ctgtttctca gtacatacct tggtcatggt   3360

ttactaattg attactttga gaagaagaga aggcgcaaca acaacaatga tgaagtcaat   3420

gccaataact tagaatggtt atcaagtctg tgggactggt acaccagcta cctcttccac   3480

ccgattgctt cttttcagaa ctttcctgta gaatctgatt gggacgaaga ccctgactta   3540

ttcttggagc gcttagcttt ccctgacctt tggcttcacc ctctgatacc aactgattat   3600

attaaaaact taccaatgtg gcgatttaaa tgtcttggag tccagtctga agaggaaatg   3660

tcggaggggt ctcaagatac tgaaaatgac tcggaaagtg agaacacaga cactttgagt   3720

agtgagaagg aagtatttga agataagcaa agcgtacttc acaattctcc aggaacagca   3780

agtcactgtg atgctgaggc ttgttcatgt gccaataaat attgtcagac cagcccatgt   3840

gaaaggaagg ggaggtcata tggatcatat aacactaatg aagatatgga acctgattgg   3900

ttaacttggc ctgctgatat gctgcactgt actgaatgtg ttgtttgcct agagaatttt   3960

gaaaatggat gtttgctaat ggggttgcct tgtggtcatg tgtttcatca gaattgcatt   4020

gtgatgtggt tggctggggg ccgacattgt tgccctgttt gccggtggcc ttcttataaa   4080

aaaaagcagc catatgcaca acaccagccc ttgtcaaatg atgtcccatc ttaaccatgt   4140

gcaatttgtc ctttataagc tttgagtatc ttacagcttg cctttttaat gttagtcaca   4200

atgtttttgt ggtttgaagt ttagtttaat gttagtgcag tgacgggaaa tacacattat   4260

gctaatgttg atgacagaat ttatttggtt gccttgtgtg ttaattgaat gcatacctaa   4320

ttgtaaaatt tttttattta caacattgga aattcagaag ttaatgtttt tttgtaagca   4380

caaaagaagt attatagaaa tttatcctag caagacttta caagatagga tcaaattcta   4440

atggaattga gccggtttct tatcctaaat gtttcctccc tttttacaat ctctgtccag   4500

cacctcttgg ttaaataatg tatgctgtga gacatgaaat taaaacagac ctatgaaata   4560

aattatttta aaaccagaag att                                           4583


<210>  7850
<211>  546
<212>  PRT
<213>  Homosapiens

<400>  7850

Met Val Lys Lys Val Ser Arg Phe Gly Ile Arg Thr Gly Thr Phe Asn 
1               5                   10                  15      


Cys Ser Ser Asp Pro Arg Tyr Cys Arg Arg Arg Gly Trp Val Arg Ser 
            20                  25                  30          


Thr Leu Ile Met Ser Val Pro Gln Thr Ser Thr Ser Lys Gly Lys Val 
        35                  40                  45              


Met Leu Lys Glu Tyr Ser Gly Arg Lys Ile Glu Val Glu His Ile Phe 
    50                  55                  60                  


Lys Trp Ile Thr Ala His Ala Ala Ser Arg Ile Lys Thr Ile Tyr Asn 
65                  70                  75                  80  


Ala Glu His Leu Lys Glu Glu Trp Asn Lys Ser Asp Gln Tyr Trp Leu 
                85                  90                  95      


Lys Ile Tyr Leu Phe Ala Asn Leu Asp Gln Pro Pro Ala Phe Phe Ser 
            100                 105                 110         


Ala Leu Ser Ile Lys Phe Thr Gly Arg Val Glu Phe Ile Phe Val Asn 
        115                 120                 125             


Val Glu Asn Trp Asp Asn Lys Ser Tyr Met Thr Asp Ile Gly Ile Tyr 
    130                 135                 140                 


Asn Met Pro Ser Tyr Ile Leu Arg Thr Pro Glu Gly Ile Tyr Arg Tyr 
145                 150                 155                 160 


Gly Asn His Thr Gly Glu Phe Ile Ser Leu Gln Ala Met Asp Ser Phe 
                165                 170                 175     


Leu Arg Ser Leu Gln Pro Glu Val Asn Asp Leu Phe Val Leu Ser Leu 
            180                 185                 190         


Val Leu Val Asn Leu Met Ala Trp Met Asp Leu Phe Ile Thr Gln Gly 
        195                 200                 205             


Ala Thr Ile Lys Arg Phe Val Val Leu Ile Ser Thr Leu Gly Thr Tyr 
    210                 215                 220                 


Asn Ser Leu Leu Ile Ile Ser Trp Leu Pro Val Leu Gly Phe Leu Gln 
225                 230                 235                 240 


Leu Pro Tyr Leu Asp Ser Phe Tyr Glu Tyr Ser Leu Lys Leu Leu Arg 
                245                 250                 255     


Tyr Ser Asn Thr Thr Thr Leu Ala Ser Trp Val Arg Ala Asp Trp Met 
            260                 265                 270         


Phe Tyr Ser Ser His Pro Ala Leu Phe Leu Ser Thr Tyr Leu Gly His 
        275                 280                 285             


Gly Leu Leu Ile Asp Tyr Phe Glu Lys Lys Arg Arg Arg Asn Asn Asn 
    290                 295                 300                 


Asn Asp Glu Val Asn Ala Asn Asn Leu Glu Trp Leu Ser Ser Leu Trp 
305                 310                 315                 320 


Asp Trp Tyr Thr Ser Tyr Leu Phe His Pro Ile Ala Ser Phe Gln Asn 
                325                 330                 335     


Phe Pro Val Glu Ser Asp Trp Asp Glu Asp Pro Asp Leu Phe Leu Glu 
            340                 345                 350         


Arg Leu Ala Phe Pro Asp Leu Trp Leu His Pro Leu Ile Pro Thr Asp 
        355                 360                 365             


Tyr Ile Lys Asn Leu Pro Met Trp Arg Phe Lys Cys Leu Gly Val Gln 
    370                 375                 380                 


Ser Glu Glu Glu Met Ser Glu Gly Ser Gln Asp Thr Glu Asn Asp Ser 
385                 390                 395                 400 


Glu Ser Glu Asn Thr Asp Thr Leu Ser Ser Glu Lys Glu Val Phe Glu 
                405                 410                 415     


Asp Lys Gln Ser Val Leu His Asn Ser Pro Gly Thr Ala Ser His Cys 
            420                 425                 430         


Asp Ala Glu Ala Cys Ser Cys Ala Asn Lys Tyr Cys Gln Thr Ser Pro 
        435                 440                 445             


Cys Glu Arg Lys Gly Arg Ser Tyr Gly Ser Tyr Asn Thr Asn Glu Asp 
    450                 455                 460                 


Met Glu Pro Asp Trp Leu Thr Trp Pro Ala Asp Met Leu His Cys Thr 
465                 470                 475                 480 


Glu Cys Val Val Cys Leu Glu Asn Phe Glu Asn Gly Cys Leu Leu Met 
                485                 490                 495     


Gly Leu Pro Cys Gly His Val Phe His Gln Asn Cys Ile Val Met Trp 
            500                 505                 510         


Leu Ala Gly Gly Arg His Cys Cys Pro Val Cys Arg Trp Pro Ser Tyr 
        515                 520                 525             


Lys Lys Lys Gln Pro Tyr Ala Gln His Gln Pro Leu Ser Asn Asp Val 
    530                 535                 540                 


Pro Ser 
545     


<210>  7851
<211>  3476
<212>  DNA
<213>  Homosapiens

<400>  7851
ggctccggcc gcggccgccg ctgatacacg gttgtggagg gtacggccgc ggtctccgga     60

ggtggcgggg gtgttgggga cgggtgctgc gaccggcact gcccatccga gcgggacggg    120

cgctgagtgg ccgggaggca gccgggtagc cgcctggagg agcagtctcg gggcctatta    180

ttggtttttt ccctccgaga ccgattccat ctgcagagac cgcgacgccc catcctgggc    240

cgggccgcag tgcccgcccg cctgagaggc gccgcccgcc agccggcccg agcgaacctg    300

gagccgccgc cgtgcccgcc gctcttctcg cggagcctgg gcggtcggcg gggcctgggg    360

cctgggcttc gggcgcggcg ttgcggcggc cgctcctccc cgcgcagaac acgctgggcc    420

ccgggcctgg cccggccgag cgccgcgccc tcctgacccg cggccgcggg agtccggccc    480

ccacggcccc tcgggccccg gcctgccgcc cggatccccg cctcctgggc ggatctgagt    540

tattttttgg tctccccctc ccccttgaga tcgcggcacc ggagggccga ccccgccacc    600

tgggtcagtg cccgccccgg gggaagcgtc cctcgttttg ttcttccccg cgagctctcc    660

ccgcgcccct ctcctttctg tgcttaatgg atgggggttt tgagtttttc ccctttattt    720

ttgtcggctc ttgactggga ggcccggcgc gaggctctgc gtctctgcgt ccctcgtcgc    780

cgcctcgcgc ccgcgcggat cccgtcacct gcttccccgc cggggatggc cggccagtga    840

cggcgccggg tggcccgcgc gtggacacgg ggccctcgcc caagctgcca ccgagccgcg    900

gcccccgccc tcgacccttc tctctcccgt attccgagct ctctggaaag agaggaaact    960

ccagggaaga tgtggctgaa gctttttttc ttgctcctct atttcctggt cctgttcgtc   1020

ctggccaggt tttttgaggc cattgtgtgg tatgaaactg gcatctttgc cacccagctg   1080

gtggatccgg tggcgctgag cttcaagaag ctgaagacca ttttggagtg ccgggggttg   1140

ggctactcag ggttgcccga gaagaaggat gtccgggagc tggtggaaaa gtcaggtgac   1200

ttgatggagg gtgagctcta ttctgctctc aaggaagaag aagcatccga atcggtttct   1260

agtaccaatt tcagtggtga aatgcacttc tatgagcttg tggaagacac aaaagatggc   1320

atctggctgg ttcaggtcat agcaaatgac agaagtccct tggtgggcaa aattcactgg   1380

gagaaaatgg ttaaaaaggt gtcaagattt ggaatacgta caggcacatt taactgttcc   1440

agtgatccca gatattgcag gagaagaggc tgggtccgat ccacactcat tatgtctgtt   1500

ccacaaacaa gtacttcaaa agggaaagtc atgcttaaag aatacagtgg acgcaagatt   1560

gaagtagagc acatttttaa atggataact gctcatgcag cttctcggat caaaaccatt   1620

tataatgctg aacacttgaa agaagaatgg aataaaagtg atcagtattg gttaaaaata   1680

tacctatttg caaaccttga ccagccccca gctttcttct ctgcactaag tataaagttt   1740

actggaagag ttgagtttat ttttgttaat gtagaaaatt gggacaacaa gagttatatg   1800

acagatattg gcatatataa tatgccatca tacatactta gaactcctga aggaatttac   1860

aggtatggaa accacacagg cgaatttata tcccttcagg ccatggattc atttttgcgc   1920

tcattacaac ccgaggtaaa tgatctgttt gttttgagct tggttctagt taatcttatg   1980

gcttggatgg acttatttat tacacaagga gctaccataa agcgatttgt ggttctcata   2040

agcactttag ggacatataa ttctctatta attatttcct ggctacctgt gttgggcttt   2100

ttacagctac cttacttaga tagcttttat gaatatagct taaaattgtt gagatattcc   2160

aatacaacca cactggcttc atgggtaagg gcagactgga tgttttactc ttcacaccca   2220

gccctgtttc tcagtacata ccttggtcat ggtttactaa ttgattactt tgagaagaag   2280

agaaggcgca acaacaacaa tgatgaagtc aatgccaata acttagaatg gttatcaagt   2340

ctgtgggact ggtacaccag ctacctcttc cacccgattg cttcttttca gaactttcct   2400

gtagaatctg attgggacga agaccctgac ttattcttgg agcgcttagc tttccctgac   2460

ctttggcttc accctctgat accaactgat tatattaaaa acttaccaat gtggcgattt   2520

aaatgtcttg gagtccagtc tgaagaggaa atgtcggagg ggtctcaaga tactgaaaat   2580

gactcggaaa gtgagaacac agacactttg agtagtgaga aggaagtatt tgaagataag   2640

caaagcgtac ttcacaattc tccaggaaca gcaagtcact gtgatgctga ggcttgttca   2700

tgtgccaata aatattgtca gaccagccca tgtgaaagga aggggaggtc atatggatca   2760

tataacacta atgaagatat ggaacctgat tggttaactt ggcctgctga tatgctgcac   2820

tgtactgaat gtgttgtttg cctagagaat tttgaaaatg gatgtttgct aatggggttg   2880

ccttgtggtc atgtgtttca tcagaattgc attgtgatgt ggttggctgg gggccgacat   2940

tgttgccctg tttgccggtg gccttcttat aaaaaaaagc agccatatgc acaacaccag   3000

cccttgtcaa atgatgtccc atcttaacca tgtgcaattt gtcctttata agctttgagt   3060

atcttacagc ttgccttttt aatgttagtc acaatgtttt tgtggtttga agtttagttt   3120

aatgttagtg cagtgacggg aaatacacat tatgctaatg ttgatgacag aatttatttg   3180

gttgccttgt gtgttaattg aatgcatacc taattgtaaa atttttttat ttacaacatt   3240

ggaaattcag aagttaatgt ttttttgtaa gcacaaaaga agtattatag aaatttatcc   3300

tagcaagact ttacaagata ggatcaaatt ctaatggaat tgagccggtt tcttatccta   3360

aatgtttcct ccctttttac aatctctgtc cagcacctct tggttaaata atgtatgctg   3420

tgagacatga aattaaaaca gacctatgaa ataaattatt ttaaaaccag aagatt       3476


<210>  7852
<211>  685
<212>  PRT
<213>  Homosapiens

<400>  7852

Met Trp Leu Lys Leu Phe Phe Leu Leu Leu Tyr Phe Leu Val Leu Phe 
1               5                   10                  15      


Val Leu Ala Arg Phe Phe Glu Ala Ile Val Trp Tyr Glu Thr Gly Ile 
            20                  25                  30          


Phe Ala Thr Gln Leu Val Asp Pro Val Ala Leu Ser Phe Lys Lys Leu 
        35                  40                  45              


Lys Thr Ile Leu Glu Cys Arg Gly Leu Gly Tyr Ser Gly Leu Pro Glu 
    50                  55                  60                  


Lys Lys Asp Val Arg Glu Leu Val Glu Lys Ser Gly Asp Leu Met Glu 
65                  70                  75                  80  


Gly Glu Leu Tyr Ser Ala Leu Lys Glu Glu Glu Ala Ser Glu Ser Val 
                85                  90                  95      


Ser Ser Thr Asn Phe Ser Gly Glu Met His Phe Tyr Glu Leu Val Glu 
            100                 105                 110         


Asp Thr Lys Asp Gly Ile Trp Leu Val Gln Val Ile Ala Asn Asp Arg 
        115                 120                 125             


Ser Pro Leu Val Gly Lys Ile His Trp Glu Lys Met Val Lys Lys Val 
    130                 135                 140                 


Ser Arg Phe Gly Ile Arg Thr Gly Thr Phe Asn Cys Ser Ser Asp Pro 
145                 150                 155                 160 


Arg Tyr Cys Arg Arg Arg Gly Trp Val Arg Ser Thr Leu Ile Met Ser 
                165                 170                 175     


Val Pro Gln Thr Ser Thr Ser Lys Gly Lys Val Met Leu Lys Glu Tyr 
            180                 185                 190         


Ser Gly Arg Lys Ile Glu Val Glu His Ile Phe Lys Trp Ile Thr Ala 
        195                 200                 205             


His Ala Ala Ser Arg Ile Lys Thr Ile Tyr Asn Ala Glu His Leu Lys 
    210                 215                 220                 


Glu Glu Trp Asn Lys Ser Asp Gln Tyr Trp Leu Lys Ile Tyr Leu Phe 
225                 230                 235                 240 


Ala Asn Leu Asp Gln Pro Pro Ala Phe Phe Ser Ala Leu Ser Ile Lys 
                245                 250                 255     


Phe Thr Gly Arg Val Glu Phe Ile Phe Val Asn Val Glu Asn Trp Asp 
            260                 265                 270         


Asn Lys Ser Tyr Met Thr Asp Ile Gly Ile Tyr Asn Met Pro Ser Tyr 
        275                 280                 285             


Ile Leu Arg Thr Pro Glu Gly Ile Tyr Arg Tyr Gly Asn His Thr Gly 
    290                 295                 300                 


Glu Phe Ile Ser Leu Gln Ala Met Asp Ser Phe Leu Arg Ser Leu Gln 
305                 310                 315                 320 


Pro Glu Val Asn Asp Leu Phe Val Leu Ser Leu Val Leu Val Asn Leu 
                325                 330                 335     


Met Ala Trp Met Asp Leu Phe Ile Thr Gln Gly Ala Thr Ile Lys Arg 
            340                 345                 350         


Phe Val Val Leu Ile Ser Thr Leu Gly Thr Tyr Asn Ser Leu Leu Ile 
        355                 360                 365             


Ile Ser Trp Leu Pro Val Leu Gly Phe Leu Gln Leu Pro Tyr Leu Asp 
    370                 375                 380                 


Ser Phe Tyr Glu Tyr Ser Leu Lys Leu Leu Arg Tyr Ser Asn Thr Thr 
385                 390                 395                 400 


Thr Leu Ala Ser Trp Val Arg Ala Asp Trp Met Phe Tyr Ser Ser His 
                405                 410                 415     


Pro Ala Leu Phe Leu Ser Thr Tyr Leu Gly His Gly Leu Leu Ile Asp 
            420                 425                 430         


Tyr Phe Glu Lys Lys Arg Arg Arg Asn Asn Asn Asn Asp Glu Val Asn 
        435                 440                 445             


Ala Asn Asn Leu Glu Trp Leu Ser Ser Leu Trp Asp Trp Tyr Thr Ser 
    450                 455                 460                 


Tyr Leu Phe His Pro Ile Ala Ser Phe Gln Asn Phe Pro Val Glu Ser 
465                 470                 475                 480 


Asp Trp Asp Glu Asp Pro Asp Leu Phe Leu Glu Arg Leu Ala Phe Pro 
                485                 490                 495     


Asp Leu Trp Leu His Pro Leu Ile Pro Thr Asp Tyr Ile Lys Asn Leu 
            500                 505                 510         


Pro Met Trp Arg Phe Lys Cys Leu Gly Val Gln Ser Glu Glu Glu Met 
        515                 520                 525             


Ser Glu Gly Ser Gln Asp Thr Glu Asn Asp Ser Glu Ser Glu Asn Thr 
    530                 535                 540                 


Asp Thr Leu Ser Ser Glu Lys Glu Val Phe Glu Asp Lys Gln Ser Val 
545                 550                 555                 560 


Leu His Asn Ser Pro Gly Thr Ala Ser His Cys Asp Ala Glu Ala Cys 
                565                 570                 575     


Ser Cys Ala Asn Lys Tyr Cys Gln Thr Ser Pro Cys Glu Arg Lys Gly 
            580                 585                 590         


Arg Ser Tyr Gly Ser Tyr Asn Thr Asn Glu Asp Met Glu Pro Asp Trp 
        595                 600                 605             


Leu Thr Trp Pro Ala Asp Met Leu His Cys Thr Glu Cys Val Val Cys 
    610                 615                 620                 


Leu Glu Asn Phe Glu Asn Gly Cys Leu Leu Met Gly Leu Pro Cys Gly 
625                 630                 635                 640 


His Val Phe His Gln Asn Cys Ile Val Met Trp Leu Ala Gly Gly Arg 
                645                 650                 655     


His Cys Cys Pro Val Cys Arg Trp Pro Ser Tyr Lys Lys Lys Gln Pro 
            660                 665                 670         


Tyr Ala Gln His Gln Pro Leu Ser Asn Asp Val Pro Ser 
        675                 680                 685 


<210>  7853
<211>  1654
<212>  DNA
<213>  Homosapiens

<400>  7853
ctcggctccg gccgcggccg ccgctgatac acggttgtgg agggtttttt gaggccattg     60

tgtggtatga aactggcatc tttgccaccc agctggtgga tccggtggcg ctgagcttca    120

agaagctgaa gaccattttg gagtgccggg ggttgggcta ctcagggttg cccgagaaga    180

aggatgtccg ggagctggtg gaaaagtcag gtgacttgat ggagggtgag ctctattctg    240

ctctcaagga agaagaagca tccgaatcgg tttctagtac caatttcagt ggtgaaatgc    300

acttctatga gcttgtggaa gacacaaaag atggcatctg gctggttcag ctctgtcagt    360

cagggatcct taaactcttc aaaaccaaat gctagaacac gttgctgaat aaataaggcc    420

ctggcattga acattgtctt gtacctgccc caggtcatag caaatgacag aagtcccttg    480

gtgggcaaaa ttcactggga gaaaatggtt aaaaaggtgt caagatttgg aatacgtaca    540

ggcacattta actgttccag tgatcccaga actttcctgt agaatctgat tgggacgaag    600

accctgactt attcttggag cgcttagctt tccctgacct ttggcttcac cctctgatac    660

caactgatta tattaaaaac ttaccaatgt ggcgatttaa atgtcttgga gtccagtctg    720

aagaggaaat gtcggagggg tctcaagata ctgaaaatga ctcggaaagt gagaacacag    780

acactttgag tagtgagaag gaagtatttg aagataagca aagcgtactt cacaattctc    840

caggaacagc aagtcactgt gatgctgagg cttgttcatg tgccaataaa tattgtcaga    900

ccagcccatg tgaaaggaag gggaggtcat atggatcata taacactaat gaagatatgg    960

aacctgattg gttaacttgg cctgctgata tgctgcactg tactgaatgt gttgtttgcc   1020

tagagaattt tgaaaatgga tgtttgctaa tggggttgcc ttgtggtcat gtgtttcatc   1080

agaattgcat tgtgatgtgg ttggctgggg gccgacattg ttgccctgtt tgccggtggc   1140

cttcttataa aaaaaagcag ccatatgcac aacaccagcc cttgtcaaat gatgtcccat   1200

cttaaccatg tgcaatttgt cctttataag ctttgagtat cttacagctt gcctttttaa   1260

tgttagtcac aatgtttttg tggtttgaag tttagtttaa tgttagtgca gtgacgggaa   1320

atacacatta tgctaatgtt gatgacagaa tttatttggt tgccttgtgt gttaattgaa   1380

tgcataccta attgtaaaat ttttttattt acaacattgg aaattcagaa gttaatgttt   1440

ttttgtaagc acaaaagaag tattatagaa atttatccta gcaagacttt acaagatagg   1500

atcaaattct aatggaattg agccggtttc ttatcctaaa tgtttcctcc ctttttacaa   1560

tctctgtcca gcacctcttg gttaaataat gtatgctgtg agacatgaaa ttaaaacaga   1620

cctatgaaat aaattatttt aaaaccagaa gatt                               1654


<210>  7854
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  7854

Met Glu Gly Glu Leu Tyr Ser Ala Leu Lys Glu Glu Glu Ala Ser Glu 
1               5                   10                  15      


Ser Val Ser Ser Thr Asn Phe Ser Gly Glu Met His Phe Tyr Glu Leu 
            20                  25                  30          


Val Glu Asp Thr Lys Asp Gly Ile Trp Leu Val Gln Leu Cys Gln Ser 
        35                  40                  45              


Gly Ile Leu Lys Leu Phe Lys Thr Lys Cys 
    50                  55              


<210>  7855
<211>  2499
<212>  DNA
<213>  Homosapiens

<400>  7855
tgttatgtct cggctccggc cgcggccgcc gctgatacac ggttgtggag ggttttttga     60

ggccattgtg tggtatgaaa ctggcatctt tgccacccag ctggtggatc cggtggcgct    120

gagcttcaag aagctgaaga ccattttgga gtgccggggg ttgggctact cagggttgcc    180

cgagaagaag gatgtccggg agctggtgga aaagtcaggt gacttgatgg agggtgagct    240

ctattctgct ctcaaggaag aagaagcatc cgaatcggtt tctagtacca atttcagtgg    300

tgaaatgcac ttctatgagc ttgtggaaga cacaaaagat ggcatctggc tggttcaggt    360

catagcaaat gacagaagtc ccttggtggg caaaattcac tgggagaaaa tggttaaaaa    420

ggtgtcaaga tttggaatac gtacaggcac atttaactgt tccagtgatc ccagatattg    480

caggagaaga ggctgggtcc gatccacact cattatgtct gttccacaaa caagtacttc    540

aaaagggaaa gtcatgctta aagaatacag tggacgcaag attgaagtag agcacatttt    600

taaatggata actgctcatg cagcttctcg gatcaaaacc atttataatg ctgaacactt    660

gaaagaagaa tggaataaaa gtgatcagta ttggttaaaa atatacctat ttgcaaacct    720

tgaccagccc ccagctttct tctctgcact aagtataaag tttactggaa gagttgagtt    780

tatttttgtt aatgtagaaa attgggacaa caagagttat atgacagata ttggcatata    840

taatatgcca tcatacatac ttagaactcc tgaaggaatt tacaggtatg gaaaccacac    900

aggcgaattt atatcccttc aggccatgga ttcatttttg cgctcattac aacccgaggt    960

aaatgatctg tttgttttga gcttggttct agttaatctt atggcttgga tggacttatt   1020

tattacacaa ggagctacca taaagcgatt tgtggttctc ataagcactt tagggacata   1080

taattctcta ttaattattt cctggctacc tgtgttgggc tttttacagc taccttactt   1140

agatagcttt tatgaatata gcttaaaatt gttgagatat tccaatacaa ccacactggc   1200

ttcatgggta agggcagact ggatgtttta ctcttcacac ccagccctgt ttctcagtac   1260

ataccttggt catggtttac taattgatta ctttgagaag aagagaaggc gcaacaacaa   1320

caatgatgaa gtcaatgcca ataacttaga atggttatca agtctgtggg actggtacac   1380

cagctacctc ttccacccga ttgcttcttt tcagaacttt cctgtagaat ctgattggga   1440

cgaagaccct gacttattct tggagcgctt agctttccct gacctttggc ttcaccctct   1500

gataccaact gattatatta aaaacttacc aatgtggcga tttaaatgtc ttggagtcca   1560

gtctgaagag gaaatgtcgg aggggtctca agatactgaa aatgactcgg aaagtgagaa   1620

cacagacact ttgagtagtg agaaggaagt atttgaagat aagcaaagcg tacttcacaa   1680

ttctccagga acagcaagtc actgtgatgc tgaggcttgt tcatgtgcca ataaatattg   1740

tcagaccagc ccatgtgaaa ggaaggggag gtcatatgga tcatataaca ctaatgaaga   1800

tatggaacct gattggttaa cttggcctgc tgatatgctg cactgtactg aatgtgttgt   1860

ttgcctagag aattttgaaa atggatgttt gctaatgggg ttgccttgtg gtcatgtgtt   1920

tcatcagaat tgcattgtga tgtggttggc tgggggccga cattgttgcc ctgtttgccg   1980

gtggccttct tataaaaaaa agcagccata tgcacaacac cagcccttgt caaatgatgt   2040

cccatcttaa ccatgtgcaa tttgtccttt ataagctttg agtatcttac agcttgcctt   2100

tttaatgtta gtcacaatgt ttttgtggtt tgaagtttag tttaatgtta gtgcagtgac   2160

gggaaataca cattatgcta atgttgatga cagaatttat ttggttgcct tgtgtgttaa   2220

ttgaatgcat acctaattgt aaaatttttt tatttacaac attggaaatt cagaagttaa   2280

tgtttttttg taagcacaaa agaagtatta tagaaattta tcctagcaag actttacaag   2340

ataggatcaa attctaatgg aattgagccg gtttcttatc ctaaatgttt cctccctttt   2400

tacaatctct gtccagcacc tcttggttaa ataatgtatg ctgtgagaca tgaaattaaa   2460

acagacctat gaaataaatt attttaaaac cagaagatt                          2499


<210>  7856
<211>  681
<212>  PRT
<213>  Homosapiens

<400>  7856

Met Ser Arg Leu Arg Pro Arg Pro Pro Leu Ile His Gly Cys Gly Gly 
1               5                   10                  15      


Phe Phe Glu Ala Ile Val Trp Tyr Glu Thr Gly Ile Phe Ala Thr Gln 
            20                  25                  30          


Leu Val Asp Pro Val Ala Leu Ser Phe Lys Lys Leu Lys Thr Ile Leu 
        35                  40                  45              


Glu Cys Arg Gly Leu Gly Tyr Ser Gly Leu Pro Glu Lys Lys Asp Val 
    50                  55                  60                  


Arg Glu Leu Val Glu Lys Ser Gly Asp Leu Met Glu Gly Glu Leu Tyr 
65                  70                  75                  80  


Ser Ala Leu Lys Glu Glu Glu Ala Ser Glu Ser Val Ser Ser Thr Asn 
                85                  90                  95      


Phe Ser Gly Glu Met His Phe Tyr Glu Leu Val Glu Asp Thr Lys Asp 
            100                 105                 110         


Gly Ile Trp Leu Val Gln Val Ile Ala Asn Asp Arg Ser Pro Leu Val 
        115                 120                 125             


Gly Lys Ile His Trp Glu Lys Met Val Lys Lys Val Ser Arg Phe Gly 
    130                 135                 140                 


Ile Arg Thr Gly Thr Phe Asn Cys Ser Ser Asp Pro Arg Tyr Cys Arg 
145                 150                 155                 160 


Arg Arg Gly Trp Val Arg Ser Thr Leu Ile Met Ser Val Pro Gln Thr 
                165                 170                 175     


Ser Thr Ser Lys Gly Lys Val Met Leu Lys Glu Tyr Ser Gly Arg Lys 
            180                 185                 190         


Ile Glu Val Glu His Ile Phe Lys Trp Ile Thr Ala His Ala Ala Ser 
        195                 200                 205             


Arg Ile Lys Thr Ile Tyr Asn Ala Glu His Leu Lys Glu Glu Trp Asn 
    210                 215                 220                 


Lys Ser Asp Gln Tyr Trp Leu Lys Ile Tyr Leu Phe Ala Asn Leu Asp 
225                 230                 235                 240 


Gln Pro Pro Ala Phe Phe Ser Ala Leu Ser Ile Lys Phe Thr Gly Arg 
                245                 250                 255     


Val Glu Phe Ile Phe Val Asn Val Glu Asn Trp Asp Asn Lys Ser Tyr 
            260                 265                 270         


Met Thr Asp Ile Gly Ile Tyr Asn Met Pro Ser Tyr Ile Leu Arg Thr 
        275                 280                 285             


Pro Glu Gly Ile Tyr Arg Tyr Gly Asn His Thr Gly Glu Phe Ile Ser 
    290                 295                 300                 


Leu Gln Ala Met Asp Ser Phe Leu Arg Ser Leu Gln Pro Glu Val Asn 
305                 310                 315                 320 


Asp Leu Phe Val Leu Ser Leu Val Leu Val Asn Leu Met Ala Trp Met 
                325                 330                 335     


Asp Leu Phe Ile Thr Gln Gly Ala Thr Ile Lys Arg Phe Val Val Leu 
            340                 345                 350         


Ile Ser Thr Leu Gly Thr Tyr Asn Ser Leu Leu Ile Ile Ser Trp Leu 
        355                 360                 365             


Pro Val Leu Gly Phe Leu Gln Leu Pro Tyr Leu Asp Ser Phe Tyr Glu 
    370                 375                 380                 


Tyr Ser Leu Lys Leu Leu Arg Tyr Ser Asn Thr Thr Thr Leu Ala Ser 
385                 390                 395                 400 


Trp Val Arg Ala Asp Trp Met Phe Tyr Ser Ser His Pro Ala Leu Phe 
                405                 410                 415     


Leu Ser Thr Tyr Leu Gly His Gly Leu Leu Ile Asp Tyr Phe Glu Lys 
            420                 425                 430         


Lys Arg Arg Arg Asn Asn Asn Asn Asp Glu Val Asn Ala Asn Asn Leu 
        435                 440                 445             


Glu Trp Leu Ser Ser Leu Trp Asp Trp Tyr Thr Ser Tyr Leu Phe His 
    450                 455                 460                 


Pro Ile Ala Ser Phe Gln Asn Phe Pro Val Glu Ser Asp Trp Asp Glu 
465                 470                 475                 480 


Asp Pro Asp Leu Phe Leu Glu Arg Leu Ala Phe Pro Asp Leu Trp Leu 
                485                 490                 495     


His Pro Leu Ile Pro Thr Asp Tyr Ile Lys Asn Leu Pro Met Trp Arg 
            500                 505                 510         


Phe Lys Cys Leu Gly Val Gln Ser Glu Glu Glu Met Ser Glu Gly Ser 
        515                 520                 525             


Gln Asp Thr Glu Asn Asp Ser Glu Ser Glu Asn Thr Asp Thr Leu Ser 
    530                 535                 540                 


Ser Glu Lys Glu Val Phe Glu Asp Lys Gln Ser Val Leu His Asn Ser 
545                 550                 555                 560 


Pro Gly Thr Ala Ser His Cys Asp Ala Glu Ala Cys Ser Cys Ala Asn 
                565                 570                 575     


Lys Tyr Cys Gln Thr Ser Pro Cys Glu Arg Lys Gly Arg Ser Tyr Gly 
            580                 585                 590         


Ser Tyr Asn Thr Asn Glu Asp Met Glu Pro Asp Trp Leu Thr Trp Pro 
        595                 600                 605             


Ala Asp Met Leu His Cys Thr Glu Cys Val Val Cys Leu Glu Asn Phe 
    610                 615                 620                 


Glu Asn Gly Cys Leu Leu Met Gly Leu Pro Cys Gly His Val Phe His 
625                 630                 635                 640 


Gln Asn Cys Ile Val Met Trp Leu Ala Gly Gly Arg His Cys Cys Pro 
                645                 650                 655     


Val Cys Arg Trp Pro Ser Tyr Lys Lys Lys Gln Pro Tyr Ala Gln His 
            660                 665                 670         


Gln Pro Leu Ser Asn Asp Val Pro Ser 
        675                 680     


<210>  7857
<211>  2530
<212>  DNA
<213>  Homosapiens

<400>  7857
tcataggtct gttttaattt catgtctcac agcatacatt atttaaccaa gaggtgctgg     60

acagagattg taaaaaggga ggaaacattt aggataagaa accggctcaa ttccattaga    120

atttgatcct atcttgtaaa gtcttgctag gataaatttc tataatactt cttttgtgct    180

tacaaaaaaa cattaacttc tgaatttcca atgttgtaaa taaaaaaatt ttacaattag    240

gtatgcattc aattaacaca caaggcaacc aaataaattc tgtcatcaac attagcataa    300

tgtgtatttc ccgtcactgc actaacatta aactaaactt caaaccacaa aaacattgtg    360

actaacatta aaaaggcaag ctgtaagata ctcaaagctt ataaaggaca aattgcacat    420

ggttaagatg ggacatcatt tgacaagggc tggtgttgtg catatggctg ctttttttta    480

taagaaggcc accggcaaac agggcaacaa tgtcggcccc cagccaacca catcacaatg    540

caattctgat gaaacacatg accacaaggc aaccccatta gcaaacatcc attttcaaaa    600

ttctctaggc aaacaacaca ttcagtacag tgcagcatat cagcaggcca agttaaccaa    660

tcaggttcca tatcttcatt agtgttatat gatccatatg acctcccctt cctttcacat    720

gggctggtct gacaatattt attggcacat gaacaagcct cagcatcaca gtgacttgct    780

gttcctggag aattgtgaag tacgctttgc ttatcttcaa atacttcctt ctcactactc    840

aaagtgtctg tgttctcact ttccgagtca ttttcagtat cttgagaccc ctccgacatt    900

tcctcttcag actggactcc aagacattta aatcgccaca ttgagactat acgtaacatg    960

gacctggaaa agcttaaaaa tatgaagagg attgaactgg ctgccatctg tgcatcttca   1020

tttatgaaaa cactcctcat agacttaaaa caaatgacag agaacaaatt agtcagcttc   1080

ttctaaaata cagtggtctc cccttaccct cagtttcact ttctgcagtc aactgcagtc   1140

cgaaaatact acatacaatt agatattcgg agagagagac accacattta cataaatgtt   1200

atttcagtat actgttataa ttgttctatt tttattagtt gttgttgtta ctgtgcctaa   1260

cttacacatt aaactttatc acaggtatgt atgtatagga aaaaacatag actatatagg   1320

atttggtact atccacggtt tcaggcatcc actgggggtc ttggaacgca tccccctcag   1380

ataagggggg actactgtaa acagaaaata acaacaattc aaattgttaa aaacaattct   1440

tgaaagttat cctttacaat agattaatat atatgatctg agctgaaaga atggcaagca   1500

atggagacaa tatttctctt ctgtttctag tagatatttt caattttaag catagtttta   1560

aaaagtacaa ccctctttta agggcttaaa ccaaggtggc tgtgctgatt ggcttagctg   1620

gctagttcac agtgccaagg acagggtttc aatctcattc ttctcagttg tcctgccaga   1680

gattgttctt tcagaccagg ccagccattt gacagatgta agccactggc ctcaaggaac   1740

acaagccaga cagtggtggt caatgcaaac cttgagcatc actggaaaaa ttaagcaggt   1800

gtcctactgc attatttcca tacatagaaa aaccacagaa atacattcta tttttaaaga   1860

gttgtttttc aactattaat acctataagg tttaaaaata ttttcagaga aaaaaaattt   1920

agcaactaga atttataatg ctaccattta ctatcattat ttgtccttca cttcatttgt   1980

caccttacca gagaattcct tgccactctc atctccttaa tctgcttatt tttcttctta   2040

ctactttcca ctaactgatg ttatattaaa tatttattta tttggtgtct gcctctccca   2100

actagaatgt gagctgcctg acagagcaag gccttagctt ggtgtgtgtt tctggtatat   2160

cttcagggcc cagaacaggg cctggcacac ccacaactga ataaactttt gatgaattct   2220

gtcacatatt tattacagga gcttaattca tggatatctt taacaggaca tcaaaaacag   2280

tagatcattt acaagccaag aacatactgc taactattga accagaatgt atttgttgtc   2340

tataggcagc agcctatata gcaaaagaac tcaagacttt tgacatagcc cttccaagtt   2400

tcaaaggtgt gcaacatctt caccatttat ttccatggga tcattcaatg tgggtgacat   2460

ttagacactg aaagcagggc agtgggactg gctattcaat tcatcctcag taataaaatc   2520

taaaattatc                                                          2530


<210>  7858
<211>  87
<212>  PRT
<213>  Homosapiens

<400>  7858

Met Val Lys Met Gly His His Leu Thr Arg Ala Gly Val Val His Met 
1               5                   10                  15      


Ala Ala Phe Phe Tyr Lys Lys Ala Thr Gly Lys Gln Gly Asn Asn Val 
            20                  25                  30          


Gly Pro Gln Pro Thr Thr Ser Gln Cys Asn Ser Asp Glu Thr His Asp 
        35                  40                  45              


His Lys Ala Thr Pro Leu Ala Asn Ile His Phe Gln Asn Ser Leu Gly 
    50                  55                  60                  


Lys Gln His Ile Gln Tyr Ser Ala Ala Tyr Gln Gln Ala Lys Leu Thr 
65                  70                  75                  80  


Asn Gln Val Pro Tyr Leu His 
                85          


<210>  7859
<211>  1406
<212>  DNA
<213>  Homosapiens

<400>  7859
taggaatata tacttttcag accatttcag ttaaaacagt aatgatatta atggaatctg     60

tcttattaag gtagtgaatc aactcaacaa gaagctaaga gtcacagtct gtgattttga    120

gtcacctaga cagttttcca gagtcatcac taaccttgtc ttaagacata gcgtgttgtc    180

ttcatttatc ttaaactata tcacagaatc cctgagataa aattagtcat attatcatta    240

tacagccata tgctacctac gtcaagactc ttctcttcat ctgatcatat gatgtgtaat    300

atgtttattt aataaaatat aatccatgct aagtaaagca taacatctat gacttttaca    360

tcaatattct gagtagcaaa atgcgaagtc agatatttat tactatgcat atacaaatct    420

gtaacaaata aaacgtttcc atgtggtaga ttgtcttttt tacaacttta ttgaggtaaa    480

ttttacttaa aaatttcaca tggtaggttt tggaaaaaaa aatacttttt aaaaacaaaa    540

gattaactct tctgtgtggt acatgaaaaa ctaactaaaa ccaaaaacaa aaggcagcct    600

gggcgacatg gtgagacccc aactctacaa aaaattcttt taaaacttag cctcccaagt    660

agctgggatt acaggcacgc gttgccatgc ccagctaatt tttatatttt tggtagagat    720

ggggtttcac catgttggcc aggatggtct caatctcctg actttgtgat ctgcccacct    780

tggcctccca aagtgctggg attacaggtg tgagccactg cacccagcct gttttcagtt    840

tttaatattt cttttctctc attacctact tttttaaggg aagatggata tcacaaatat    900

cctagcaaga acctgtcaat agacaggttt ccaaaaggaa gagtcatgat cctactgcat    960

aaatctaaat gaatgattta attttagtta aattcttctg aatataatct gctgtaaaat   1020

ggggatcatt cttgaagtga acctcttaat ctaaatactt cctgtttttg tttcctcttg   1080

ttaaatactc cccttcatga tcttcactga agaaataaga gaatacaaaa atatatgggg   1140

cttgctgttg ctcttttctt ggttggcttt tgtgcagatt actttgtagc agtcaggcat   1200

tgtggtagtt gttaattaaa tgggtaagca tgactcctac cctcaaggag cttgcaccaa   1260

accagtgact cagccttagg ataatctgtt ttcttctctt ttctccaccc atctggattc   1320

taaccatcct tcaagaccta gttcaattcc taaaccattc atgaaatctg caccagccca   1380

aactttgaac ttcttttgca ttattt                                        1406


<210>  7860
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  7860

Met Ile Phe Thr Glu Glu Ile Arg Glu Tyr Lys Asn Ile Trp Gly Leu 
1               5                   10                  15      


Leu Leu Leu Phe Ser Trp Leu Ala Phe Val Gln Ile Thr Leu 
            20                  25                  30  


<210>  7861
<211>  2913
<212>  DNA
<213>  Homosapiens

<400>  7861
gctgatacac ggttgtggag ggtacggccg cggtctccgg aggtggcggg ggtgttgggg     60

acgggtgctg cgaccggcac tgcccatccg agcgggacgg gcgctgagtg gccgggaggc    120

agccgggtag ccgcctggag gagcagtctc ggggcctatt attggttttt tccctccgag    180

accgattcca tctgcagaga ccgcgacgcc ccatcctggg ccgggccgca gtgcccgccc    240

gcctgagagg cgccgcccgc cagccggccc gagcgaacct ggagccgccg ccgtgcccgc    300

cgctcttctc gcggagcctg ggcggtcggc ggggcctggg gcctgggctt cgggcgcggc    360

gttgcggcgg ccgctcctcc ccgcgcagaa cacgctgggc cccgggcctg gcccggccga    420

gcgccgcgcc ctcctgaccc gcggccgcgg gagtccggcc cccacggccc ctcgggcccc    480

ggcctgccgc ccggatcccc gcctcctggg cggatctgag ttattttttg gtctccccct    540

cccccttgag atcgcggcac cggagggccg accccgccac ctgggtcagt gcccgccccg    600

ggggaagcgt ccctcgtttt gttcttcccc gcgagctctc cccgcgcccc tctcctttct    660

gtgcttaatg gatgggggtt ttgagttttt cccctttatt tttgtcggct cttgactggg    720

aggcccggcg cgaggctctg cgtctctgcg tccctcgtcg ccgcctcgcg cccgcgcgga    780

tcccgtcacc tgcttccccg ccggggatgg ccggccagtg acggcgccgg gtggcccgcg    840

cgtggacacg gggccctcgc ccaagctgcc accgagccgc ggcccccgcc ctcgaccctt    900

ctctctcccg tattccgagc tctctggaaa gagaggaaac tccagggaag atgtggctga    960

agcttttttt cttgctcctc tatttcctgg tcctgttcgt cctggccagg ttttttgagg   1020

ccattgtgtg gtatgaaact ggcatctttg ccacccagct ggtggatccg gtggcgctga   1080

gcttcaagaa gctgaagacc attttggagt gccgggggtt gggctactca gggttgcccg   1140

agaagaagga tgtccgggag ctggtggaaa agtcaggtga cttgatggag ggtgagctct   1200

attctgctct caaggaagaa gaagcatccg aatcggtttc tagtaccaat ttcagtggtg   1260

aaatgcactt ctatgagctt gtggaagaca caaaagatgg catctggctg gttcagtgat   1320

gctcaaggtt tgcattgacc accactgtct ggcttgtgtt ccttgaggcc agtggcttac   1380

atctgtcaaa tggctggcct ggtctgaaag aacaatctct ggcaggacaa ctgagaagaa   1440

tgagattgaa accctgtcct tggcactgtg aactagccag ctaagccaat cagcacagcc   1500

accttggttt aagcccttaa aagagggttg tactttttaa aactatgctt aaaattgaaa   1560

atatctacta gaaacagaag agaaatattg tctccattgc ttgccattct ttcagctcag   1620

atcatatata ttaatctatt gtaaaggata actttcaaga attgttttta acaatttgaa   1680

ttgttgttat tttctgttta cagtagtccc cccttatctg agggggatgc gttccaagac   1740

ccccagtgga tgcctgaaac cgtggatagt accaaatcct atatagtcta tgttttttcc   1800

tatacataca tacctgtgat aaagtttaat gtgtaagtta ggcacagtaa caacaacaac   1860

taataaaaat agaacaatta taacagtata ctgaaataac atttatgtaa atgtggtgtc   1920

tctctctccg aatatctaat tgtatgtagt attttcggac tgcagttgac tgcagaaagt   1980

gaaactgagg gtaaggggag accactgtat tttagaagaa gctgactaat ttgttctctg   2040

tcatttgttt taagtctatg aggagtgttt tcataaatga agatgcacag atggcagcca   2100

gttcaatcct cttcatattt ttaagctttt ccaggtccat gttacgtata gtctctgtaa   2160

tgtgaacaga atttatttta gttttcaagg tagcaacata catatgacat ctttaccaat   2220

gacacactat gaaatacatg tagaaccaag tgctcttttt tctaagttat tcctaacatt   2280

gtttttctcc tttgtcccta acccaagctc atatctttca ttagctattc atttaacagt   2340

tttgtggatt ctttggcccc agtcttcata gcattacaaa tagaagatgg ttacttttct   2400

ttcaaaagac ccttggtcag agaggcagat ggcacagtgg ataggcttct gaagtggaga   2460

agttagcata atttatgggt tttatggatt tatcctcctc ctaacatttc tgtttctccg   2520

ttttgacttt tgtcatagtt caaagaagga catatttgtt ccctactggc tgtgttacat   2580

catatggaat ttaaagtcac tggaattgag gtagcagtga gaagcatcat atgatttaaa   2640

ataaagcttt gggtcaatat ttactgaagt attacatcaa tatatttcct gtttggctga   2700

caagagttaa tagctgattt taaacttgtt tatctttgct cctagacaaa agttttgttc   2760

gaggagattc taaattacgt atttctttct tgatactgct atggaggtga agcacatagc   2820

aagccacttt atcttatatt ttgtattggt aaaaaatttt ataaattcta tgtaagaata   2880

caaaaaaatt aaaagaccac tgttttttgt caa                                2913


<210>  7862
<211>  122
<212>  PRT
<213>  Homosapiens

<400>  7862

Met Trp Leu Lys Leu Phe Phe Leu Leu Leu Tyr Phe Leu Val Leu Phe 
1               5                   10                  15      


Val Leu Ala Arg Phe Phe Glu Ala Ile Val Trp Tyr Glu Thr Gly Ile 
            20                  25                  30          


Phe Ala Thr Gln Leu Val Asp Pro Val Ala Leu Ser Phe Lys Lys Leu 
        35                  40                  45              


Lys Thr Ile Leu Glu Cys Arg Gly Leu Gly Tyr Ser Gly Leu Pro Glu 
    50                  55                  60                  


Lys Lys Asp Val Arg Glu Leu Val Glu Lys Ser Gly Asp Leu Met Glu 
65                  70                  75                  80  


Gly Glu Leu Tyr Ser Ala Leu Lys Glu Glu Glu Ala Ser Glu Ser Val 
                85                  90                  95      


Ser Ser Thr Asn Phe Ser Gly Glu Met His Phe Tyr Glu Leu Val Glu 
            100                 105                 110         


Asp Thr Lys Asp Gly Ile Trp Leu Val Gln 
        115                 120         


<210>  7863
<211>  754
<212>  DNA
<213>  Homosapiens

<400>  7863
gaggaagtta agctttaaaa taaagaacag ggagctgaac ttactgatac cagaactcat     60

tgtacttaac aatttacagg ctaaaacctt tgaagaggaa tttattatat cctacaactg    120

ggttatatgg ctttgacacc agcacctctc tatgaagaaa agagtgtgtt gtgaacgaag    180

tcagaatttc ctgtgttccc tttgccgctc ctggagttca ctggttctcc ttccagggaa    240

cccagcctta gatgattaaa aaaattgagg agggcctgaa gaagcagggc agcagtgctc    300

tggaggtggc agaatcacag ctggtgttaa cgaggaagga caggaaagag gctcacaatc    360

gcagcagggg ctgggcctgg agaaggtatt ctgtggcaag ttggattttc tcacagcacc    420

gatacagtag gtaggtgcgt gctgacggct taatcttaac tctccttttt tattgaccat    480

aaatgccata tttaaatcaa ctataaatga tacaattaca tactgcccag tggtaagctt    540

tcaaaatgta aatcagtctg ggaatacaga aatcgattat aagtattttc aatgatcttt    600

gtttaactgt ttaggggact ccccggaagt gggcttgtgt aagtgtggga aatgtgggag    660

gaaagggcta gaaaagggaa gaggagcttg ggctgagagg gaagaatcca gggggactgt    720

aggtggcagg gtgtgtgtgt gtgcacctcc tggc                                754


<210>  7864
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  7864

Met Ile Lys Lys Ile Glu Glu Gly Leu Lys Lys Gln Gly Ser Ser Ala 
1               5                   10                  15      


Leu Glu Val Ala Glu Ser Gln Leu Val Leu Thr Arg Lys Asp Arg Lys 
            20                  25                  30          


Glu Ala His Asn Arg Ser Arg Gly Trp Ala Trp Arg Arg Tyr Ser Val 
        35                  40                  45              


Ala Ser Trp Ile Phe Ser Gln His Arg Tyr Ser Arg 
    50                  55                  60  


<210>  7865
<211>  2487
<212>  DNA
<213>  Homosapiens

<400>  7865
ggcccacacc attagagtgg cggcgcgtgt gggcgcccgt cgcgttcctc cgcccgttct     60

cgccgggtcg caccccccac cccgagggtg tacttggtac ggcccgcgcc gcctcctttc    120

ctcgcccggg tggccatccc cctcccccca gtcggcggcg cttggtgccg cccgggagaa    180

ccaggtcatc ggtcggttcc cgtgaaaaca aaaacaatcg gccgcgccgt cgcaggcacc    240

cgaacgtcgc gagcggggcc tggggacgcg gagccgagtg cagcgagcga acgggagcag    300

cggcgactcg ccggggggct agggcgccat ggggcaggcg ggctccggct gcgcggggct    360

cccccggcgc cgcggctagt gcgcccgccg cctcggccgc ctcagcctcc cgcgccgccc    420

gcttggggaa cgaggagcag gacgcggcct cggtggggcc cgggccgaac ggctgcggac    480

acctgggcgc cgaggagccg agcgccgccg cctccggcat ggatcagtgc gtgacggtgg    540

agcgcgagct ggagaaggtg ctgcacaagt tctcaggcta cgggcagctg tgcgagcgcg    600

gcctggagga gctcatcgac tacaccggcg gcctcaagca cgagatcctg cagagccacg    660

gccaagatgc tgaattatca gggacacttt cacttgtttt gacacagtgc tgtaaaagaa    720

taaaggatac tgttcaaaaa ttggcctccg accacaaaga catccacagc agtgtttctc    780

gggttggaaa agccattgat aagaattttg attctgacat tagcagtgtg ggaatagatg    840

gctgctggca ggcagacagc caaaggcttc tcaatgaggt gatggtggag cacttctttc    900

gacaaggaat gctggatgtg gctgaggagc tctgtcagga atctggtctt tctgtagacc    960

caagtcagaa ggaaccattt gtggagttaa atagaatatt agaggcatta aaggtcagag   1020

ttctgagacc tgctctggag tgggcagtgt caaaccggga aatgcttata gctcaaaaca   1080

gctccttgga atttaagcta cacagactgt attttattag cttgttaatg ggtggaacca   1140

caaatcagcg agaggcatta caatatgcta aaaattttca gccatttgcc ctaaatcatc   1200

aaaaagacat tcaggttttg atgggaagcc ttgtgtacct gagacaaggg attgagaact   1260

caccatatgt tcacctactt gatgcaaacc agtgggctga tatctgtgac atctttacac   1320

gggatgcttg tgccctcctg gggctctccg tggagtcccc tctcagtgtc agtttctcag   1380

caggttgtgt ggcgctgcca gctttaatta acatcaaagc cgtgattgaa cagaggcagt   1440

gtactggagt ttggaaccag aaagatgaat tacctattga agtggacctt ggtaaaaagt   1500

gctggtatca ctctatattt gcctgcccca ttcttcgtca gcaaacaaca gataacaatc   1560

cacccatgaa attggtctgt ggtcatatta tatcaagaga tgccctgaat aaaatgttta   1620

atggtagcaa attaaaatgt ccctactgtc caatggaaca aagtccagga gatgccaaac   1680

agatattttt ctgaagagat aactttagtt tgcaatttgt aagtgaaact gaatcgtggg   1740

tgcatttcag aagagaacgt tccatataat gcagctaacc aaggactcct gtgtttctat   1800

aagctaatgc tccagaaact ttgccaacct gttagtgtac acacactgag gggagtgctc   1860

ccggtgaata ttatcatagg gctttattat attcttggtc ttcatttctg atcaagtaaa   1920

tacaccagca gttgtcattc aatgcaggtt tttgtactta attatatggt gattttttta   1980

ctttttaaga gcagaaacgg aaattgacct ccccgccatg tgtttaatat tcctcctgct   2040

tttacttttg tcattttctt gataatcgta agccttgaga gtgtttgtga aaaagtttta   2100

tttcctgtta tgtatacata attaaatgaa aattcttcag aaaaagtttg ataaattgaa   2160

ttgtggttat gaaactaatt tgcattttta tttgcttaag aaagaaagct gtgatagatt   2220

ccagatatgc tttttgatgt tttcctctgc tccagctcca agaagtcagc acacctgcat   2280

tttagctctg catgcagccc cagcaggctg cgtgtttaag aatttcattg tttaactggc   2340

tggtgtgaga agtcttccgt tagcatagag tggaaggagt actattgttt ggttgggttt   2400

ttgtttgttt gttttttgtt tttgctttta ttgccaagag gtgcttgttt taaaagtatg   2460

tttaataaaa tgaaattcta aagttag                                       2487


<210>  7866
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  7866

Met Asp Gln Cys Val Thr Val Glu Arg Glu Leu Glu Lys Val Leu His 
1               5                   10                  15      


Lys Phe Ser Gly Tyr Gly Gln Leu Cys Glu Arg Gly Leu Glu Glu Leu 
            20                  25                  30          


Ile Asp Tyr Thr Gly Gly Leu Lys His Glu Ile Leu Gln Ser His Gly 
        35                  40                  45              


Gln Asp Ala Glu Leu Ser Gly Thr Leu Ser Leu Val Leu Thr Gln Cys 
    50                  55                  60                  


Cys Lys Arg Ile Lys Asp Thr Val Gln Lys Leu Ala Ser Asp His Lys 
65                  70                  75                  80  


Asp Ile His Ser Ser Val Ser Arg Val Gly Lys Ala Ile Asp Lys Asn 
                85                  90                  95      


Phe Asp Ser Asp Ile Ser Ser Val Gly Ile Asp Gly Cys Trp Gln Ala 
            100                 105                 110         


Asp Ser Gln Arg Leu Leu Asn Glu Val Met Val Glu His Phe Phe Arg 
        115                 120                 125             


Gln Gly Met Leu Asp Val Ala Glu Glu Leu Cys Gln Glu Ser Gly Leu 
    130                 135                 140                 


Ser Val Asp Pro Ser Gln Lys Glu Pro Phe Val Glu Leu Asn Arg Ile 
145                 150                 155                 160 


Leu Glu Ala Leu Lys Val Arg Val Leu Arg Pro Ala Leu Glu Trp Ala 
                165                 170                 175     


Val Ser Asn Arg Glu Met Leu Ile Ala Gln Asn Ser Ser Leu Glu Phe 
            180                 185                 190         


Lys Leu His Arg Leu Tyr Phe Ile Ser Leu Leu Met Gly Gly Thr Thr 
        195                 200                 205             


Asn Gln Arg Glu Ala Leu Gln Tyr Ala Lys Asn Phe Gln Pro Phe Ala 
    210                 215                 220                 


Leu Asn His Gln Lys Asp Ile Gln Val Leu Met Gly Ser Leu Val Tyr 
225                 230                 235                 240 


Leu Arg Gln Gly Ile Glu Asn Ser Pro Tyr Val His Leu Leu Asp Ala 
                245                 250                 255     


Asn Gln Trp Ala Asp Ile Cys Asp Ile Phe Thr Arg Asp Ala Cys Ala 
            260                 265                 270         


Leu Leu Gly Leu Ser Val Glu Ser Pro Leu Ser Val Ser Phe Ser Ala 
        275                 280                 285             


Gly Cys Val Ala Leu Pro Ala Leu Ile Asn Ile Lys Ala Val Ile Glu 
    290                 295                 300                 


Gln Arg Gln Cys Thr Gly Val Trp Asn Gln Lys Asp Glu Leu Pro Ile 
305                 310                 315                 320 


Glu Val Asp Leu Gly Lys Lys Cys Trp Tyr His Ser Ile Phe Ala Cys 
                325                 330                 335     


Pro Ile Leu Arg Gln Gln Thr Thr Asp Asn Asn Pro Pro Met Lys Leu 
            340                 345                 350         


Val Cys Gly His Ile Ile Ser Arg Asp Ala Leu Asn Lys Met Phe Asn 
        355                 360                 365             


Gly Ser Lys Leu Lys Cys Pro Tyr Cys Pro Met Glu Gln Ser Pro Gly 
    370                 375                 380                 


Asp Ala Lys Gln Ile Phe Phe 
385                 390     


<210>  7867
<211>  3596
<212>  DNA
<213>  Homosapiens

<400>  7867
ggcccacacc attagagtgg cggcgcgtgt gggcgcccgt cgcgttcctc cgcccgttct     60

cgccgggtcg caccccccac cccgagggtg tacttggtac ggcccgcgcc gcctcctttc    120

ctcgcccggg tggccatccc cctcccccca gtcggcggcg cttggtgccg cccgggagaa    180

ccaggtcatc ggtcggttcc cgtgaaaaca aaaacaatcg gccgcgccgt cgcaggcacc    240

cgaacgtcgc gagcggggcc tggggacgcg gagccgagtg cagcgagcga acgggagcag    300

cggcgactcg ccggggggct agggcgccat ggggcaggcg ggctccggct gcgcggggct    360

cccccggcgc cgcggctagt gcgcccgccg cctcggccgc ctcagcctcc cgcgccgccc    420

gcttggggaa cgaggagcag gacgcggcct cggtggggcc cgggccgaac ggctgcggac    480

acctgggcgc cgaggagccg agcgccgccg cctccggcat ggatcagtgc gtgacggtgg    540

agcgcgagct ggagaaggtg ctgcacaagt tctcaggcta cgggcagctg tgcgagcgcg    600

gcctggagga gctcatcgac tacaccggcg gcctcaagca cgagatcctg cagagccacg    660

gccaagatgc tgaattatca gggacacttt cacttgtttt gacacagtgc tgtaaaagaa    720

taaaggatac tgttcaaaaa ttggcctccg accacaaaga catccacagc agtgtttctc    780

gggttggaaa agccattgat aagaattttg attctgacat tagcagtgtg ggaatagatg    840

gctgctggca ggcagacagc caaaggcttc tcaatgaggt gatggtggag cacttctttc    900

gacaaggaat gctggatgtg gctgaggagc tctgtcagga atctggtctt tctgtagacc    960

caagtcagaa ggaaccattt gtggagttaa atagaatatt agaggcatta aaggtcagag   1020

ttctgagacc tgctctggag tgggcagtgt caaaccggga aatgcttata gctcaaaaca   1080

gctccttgga atttaagcta cacagactgt attttattag cttgttaatg ggtggaacca   1140

caaatcagcg agaggcatta caatatgcta aaaattttca gccatttgcc ctaaatcatc   1200

aaaaagacat tcaggttttg atgggaagcc ttgtgtacct gagacaaggg attgagaact   1260

caccatatgt tcacctactt gatgcaaacc agtgggctga tatctgtgac atctttacac   1320

gggatgcttg tgccctcctg gggctctccg tggagtcccc tctcagtgtc agtttctcag   1380

caggttgtgt ggcgctgcca gctttaatta acatcaaagc cgtgattgaa cagaggcagt   1440

gtactggagt ttggaaccag aaagatgaat tacctattga agtggacctt ggtaaaaagt   1500

gctggtatca ctctatattt gcctgcccca ttcttcgtca gcaaacaaca gataacaatc   1560

cacccatgaa attggtctgt ggtcatatta tatcaagaga tgccctgaat aaaatgttta   1620

atggtagcaa attaaaatgt ccctactgtc caatggaaca aagtccagga gatgccaaac   1680

agatattttt ctgaagagat aactttagtt tgcaatttgt aagtgaaact gaatcgtggg   1740

tgcatttcag aagagaacgt tccatataat gcagctaacc aaggactcct gtgtttctat   1800

aagctaatgc tccagaaact ttgccaacct gttagtgtac acacactgag gggagtgctc   1860

ccggtgaata ttatcatagg gctttattat attcttggtc ttcatttctg atcaagtaaa   1920

tacaccagca gttgtcattc aatgcaggtt tttgtactta attatatggt gattttttta   1980

ctttttaaga gcagaaacgg aaattgacct ccccgccatg tgtttaatat tcctcctgct   2040

tttacttttg tcattttctt gataatcgta agccttgaga gtgtttgtga aaaagtttta   2100

tttcctgtta tgtatacata attaaatgaa aattcttcag aaaaagtttg ataaattgaa   2160

ttgtggttat gaaactaatt tgcattttta tttgcttaag aaagaaagct gtgatagatt   2220

ccagatatgc tttttgatgt tttcctctgc tccagctcca agaagtcagc acacctgcat   2280

tttagctctg catgcagccc cagcaggctg cgtgtttaag aatttcattg tttaactggc   2340

tggtgtgaga agtcttccgt tagcatagag tggaaggagt actattgttt ggttgggttt   2400

ttgtttgttt gttttttgtt tttgctttta ttgccaagag gtgcttgttt taaaagtatg   2460

tttaataaaa tgaaattcta aagttagaag tgttcttaag ttgatattta ctctcttggt   2520

cttggtagcc ctattatatc attgcagaca cagtgttgtg catgtgtgta ttgtatatgt   2580

gcaccagcat caaacattgt gtatctggaa ggaaagcagc atgttccagt tctaaaatgc   2640

agttaccaga cccatcactt taaatcctta aagttagaag ctagcaaatt ttctgtagtg   2700

cagaacgttt attgctgttt ttgtgtttga atagtataat gtttgatgcc tctcttctgc   2760

aaagcgtatc atctcattga ctgtgaatct gtatattatt ctgatggata cagataatga   2820

tcttttctct tgtgaggtat cttcatttat gcactgtcca aaaatagcca tgtgtaagag   2880

tctttctgta tgacgaacta catggaaaag acttctgtgg acataattct gaccgaaacc   2940

catgaagtta cttcagtata agaagaacgt tacacggaaa tcaccaaata ttttgcaact   3000

ttatttcttc tgacatggag tgaacatcaa taggaatact ttcaaagaaa atgaaaacac   3060

agaagcaaag agaaatgtgg cacttcacat tttaaactac agatggactt ggtttgaggg   3120

agggggaatc acagatttgg tgctaagtta attagaaact ggcagcgttt tacagtagta   3180

caccagcctg gatgtttttt ctaaaatgtt tacctgggag agctggggtt tgtttgtgag   3240

gagaaagagt actgtggaaa acctctgctt gagtaccatg tggccaggcc tatgtggatg   3300

gctactccgt gctgtgcggc ttcaccagcg gttgggattg gcccagcttg gagtgcttgt   3360

gtggtccaac ctcagtctgg ccccatagcg acttttgccc catgattctg cttcactgtt   3420

ggaatcctct ttgaagttcc ccctctcttt gctaaagcag tgaaggaaga gaacagagac   3480

aaactctttg gactgtgaaa gagaaggtag agaattccag gcaacagtct gaccaagggt   3540

gtaaaccagt ttattatata tatatttttc ctttgaatta aaacctagag tgttgt       3596


<210>  7868
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  7868

Met Asp Gln Cys Val Thr Val Glu Arg Glu Leu Glu Lys Val Leu His 
1               5                   10                  15      


Lys Phe Ser Gly Tyr Gly Gln Leu Cys Glu Arg Gly Leu Glu Glu Leu 
            20                  25                  30          


Ile Asp Tyr Thr Gly Gly Leu Lys His Glu Ile Leu Gln Ser His Gly 
        35                  40                  45              


Gln Asp Ala Glu Leu Ser Gly Thr Leu Ser Leu Val Leu Thr Gln Cys 
    50                  55                  60                  


Cys Lys Arg Ile Lys Asp Thr Val Gln Lys Leu Ala Ser Asp His Lys 
65                  70                  75                  80  


Asp Ile His Ser Ser Val Ser Arg Val Gly Lys Ala Ile Asp Lys Asn 
                85                  90                  95      


Phe Asp Ser Asp Ile Ser Ser Val Gly Ile Asp Gly Cys Trp Gln Ala 
            100                 105                 110         


Asp Ser Gln Arg Leu Leu Asn Glu Val Met Val Glu His Phe Phe Arg 
        115                 120                 125             


Gln Gly Met Leu Asp Val Ala Glu Glu Leu Cys Gln Glu Ser Gly Leu 
    130                 135                 140                 


Ser Val Asp Pro Ser Gln Lys Glu Pro Phe Val Glu Leu Asn Arg Ile 
145                 150                 155                 160 


Leu Glu Ala Leu Lys Val Arg Val Leu Arg Pro Ala Leu Glu Trp Ala 
                165                 170                 175     


Val Ser Asn Arg Glu Met Leu Ile Ala Gln Asn Ser Ser Leu Glu Phe 
            180                 185                 190         


Lys Leu His Arg Leu Tyr Phe Ile Ser Leu Leu Met Gly Gly Thr Thr 
        195                 200                 205             


Asn Gln Arg Glu Ala Leu Gln Tyr Ala Lys Asn Phe Gln Pro Phe Ala 
    210                 215                 220                 


Leu Asn His Gln Lys Asp Ile Gln Val Leu Met Gly Ser Leu Val Tyr 
225                 230                 235                 240 


Leu Arg Gln Gly Ile Glu Asn Ser Pro Tyr Val His Leu Leu Asp Ala 
                245                 250                 255     


Asn Gln Trp Ala Asp Ile Cys Asp Ile Phe Thr Arg Asp Ala Cys Ala 
            260                 265                 270         


Leu Leu Gly Leu Ser Val Glu Ser Pro Leu Ser Val Ser Phe Ser Ala 
        275                 280                 285             


Gly Cys Val Ala Leu Pro Ala Leu Ile Asn Ile Lys Ala Val Ile Glu 
    290                 295                 300                 


Gln Arg Gln Cys Thr Gly Val Trp Asn Gln Lys Asp Glu Leu Pro Ile 
305                 310                 315                 320 


Glu Val Asp Leu Gly Lys Lys Cys Trp Tyr His Ser Ile Phe Ala Cys 
                325                 330                 335     


Pro Ile Leu Arg Gln Gln Thr Thr Asp Asn Asn Pro Pro Met Lys Leu 
            340                 345                 350         


Val Cys Gly His Ile Ile Ser Arg Asp Ala Leu Asn Lys Met Phe Asn 
        355                 360                 365             


Gly Ser Lys Leu Lys Cys Pro Tyr Cys Pro Met Glu Gln Ser Pro Gly 
    370                 375                 380                 


Asp Ala Lys Gln Ile Phe Phe 
385                 390     


<210>  7869
<211>  2501
<212>  DNA
<213>  Homosapiens

<400>  7869
ggcccacacc attagagtgg cggcgcgtgt gggcgcccgt cgcgttcctc cgcccgttct     60

cgccgggtcg caccccccac cccgagggtg tacttggtac ggcccgcgcc gcctcctttc    120

ctcgcccggg tggccatccc cctcccccca gtcggcggcg cttggtgccg cccgggagaa    180

ccaggtcatc ggtcggttcc cgtgaaaaca aaaacaatcg gccgcgccgt cgcaggcacc    240

cgaacgtcgc gagcggggcc tggggacgcg gagccgagtg cagcgagcga acgggagcag    300

cggcgactcg ccggggggct agggcgccat ggggcaggcg ggctccggct gcgcggggct    360

cccccggcgc cgcggctagt gcgcccgccg cctcggccgc ctcagcctcc cgcgccgccc    420

gcttggggaa cgaggagcag gacgcggcct cggtggggcc cgggccgaac ggctgcggac    480

acctgggcgc cgaggagccg agcgccgccg cctccggcat ggatcagtgc gtgacggtgg    540

agcgcgagct ggagaaggtg ctgcacaagt tctcaggcta cgggcagctg tgcgagcgcg    600

gcctggagga gctcatcgac tacaccggcg gcctcaagca cgagatcctg cagagccacg    660

gccaagatgc tgaattatca gggacacttt cacttgtttt gacacagtgc tgtaaaagaa    720

taaaggatac tgttcaaaaa ttggcctccg accacaaaga catccacagc agtgtttctc    780

gggttggaaa agccattgat aagaattttg attctgacat tagcagtgtg ggaatagatg    840

gctgctggca ggcagacagc caaaggcttc tcaatgaggt gatggtggag cacttctttc    900

gacaaggaat gctggatgtg gctgaggagc tctgtcagga atctggtctt tctgtagacc    960

caagtcagaa ggaaccattt gtggagttaa atagaatatt agaggcatta aaggtcagag   1020

ttctgagacc tgctctggag tgggcagtgt caaaccggga aatgcttata gctcaaaaca   1080

gctccttgga atttaagcta cacagactgt attttattag cttgttaatg ggtggaacca   1140

caaatcagcg agaggcatta caatatgcta aaaattttca gccatttgcc ctaaatcatc   1200

aaaaagacat tcaggttttg atgggaagcc ttgtgtacct gagacaaggg attgagaact   1260

caccatatgt tcacctactt gatgcaaacc agtgggctga tatctgtgac atctttacac   1320

gggatgcttg tgccctcctg gggctctccg tggagtcccc tctcagtgtc agtttctcag   1380

caggttgtgt ggcgctgcca gctttaatta acatcaaagc cgtgattgaa cagaggcagt   1440

gtactggagt ttggaaccag aaagatgaat tacctattga agtggacctt ggtaaaaagt   1500

gctggtatca ctctatattt gcctgcccca ttcttcgtca gcaaacaaca gataacaatc   1560

cacccatgaa attggtctgt ggtcatatta tatcaagaga tgccctgaat aaaatgttta   1620

atggtagcaa attaaaatgt ccctactgtc caatggaaca aagtccagga gatgccaaac   1680

agatattttt ctgaagagat aactttagtt tgcaatttat aatgatcttt tctcttgtga   1740

ggtatcttca tttatgcact gtccaaaaat agccatgtgt aagagtcttt ctgtatgacg   1800

aactacatgg aaaagacttc tgtggacata attctgaccg aaacccatga agttacttca   1860

gtataagaag aacgttacac ggaaatcacc aaatattttg caactttatt tcttctgaca   1920

tggagtgaac atcaatagga atactttcaa agaaaatgaa aacacagaag caaagagaaa   1980

tgtggcactt cacattttaa actacagatg gacttggttt gagggagggg gaatcacaga   2040

tttggtgcta agttaattag aaactggcag cgttttacag tagtacacca gcctggatgt   2100

tttttctaaa atgtttacct gggagagctg gggtttgttt gtgaggagaa agagtactgt   2160

ggaaaacctc tgcttgagta ccatgtggcc aggcctatgt ggatggctac tccgtgctgt   2220

gcggcttcac cagcggttgg gattggccca gcttggagtg cttgtgtggt ccaacctcag   2280

tctggcccca tagcgacttt tgccccatga ttctgcttca ctgttggaat cctctttgaa   2340

gttccccctc tctttgctaa agcagtgaag gaagagaaca gagacaaact ctttggactg   2400

tgaaagagaa ggtagagaat tccaggcaac agtctgacca agggtgtaaa ccagtttatt   2460

atatatatat ttttcctttg aattaaaacc tagagtgttg t                       2501


<210>  7870
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  7870

Met Asp Gln Cys Val Thr Val Glu Arg Glu Leu Glu Lys Val Leu His 
1               5                   10                  15      


Lys Phe Ser Gly Tyr Gly Gln Leu Cys Glu Arg Gly Leu Glu Glu Leu 
            20                  25                  30          


Ile Asp Tyr Thr Gly Gly Leu Lys His Glu Ile Leu Gln Ser His Gly 
        35                  40                  45              


Gln Asp Ala Glu Leu Ser Gly Thr Leu Ser Leu Val Leu Thr Gln Cys 
    50                  55                  60                  


Cys Lys Arg Ile Lys Asp Thr Val Gln Lys Leu Ala Ser Asp His Lys 
65                  70                  75                  80  


Asp Ile His Ser Ser Val Ser Arg Val Gly Lys Ala Ile Asp Lys Asn 
                85                  90                  95      


Phe Asp Ser Asp Ile Ser Ser Val Gly Ile Asp Gly Cys Trp Gln Ala 
            100                 105                 110         


Asp Ser Gln Arg Leu Leu Asn Glu Val Met Val Glu His Phe Phe Arg 
        115                 120                 125             


Gln Gly Met Leu Asp Val Ala Glu Glu Leu Cys Gln Glu Ser Gly Leu 
    130                 135                 140                 


Ser Val Asp Pro Ser Gln Lys Glu Pro Phe Val Glu Leu Asn Arg Ile 
145                 150                 155                 160 


Leu Glu Ala Leu Lys Val Arg Val Leu Arg Pro Ala Leu Glu Trp Ala 
                165                 170                 175     


Val Ser Asn Arg Glu Met Leu Ile Ala Gln Asn Ser Ser Leu Glu Phe 
            180                 185                 190         


Lys Leu His Arg Leu Tyr Phe Ile Ser Leu Leu Met Gly Gly Thr Thr 
        195                 200                 205             


Asn Gln Arg Glu Ala Leu Gln Tyr Ala Lys Asn Phe Gln Pro Phe Ala 
    210                 215                 220                 


Leu Asn His Gln Lys Asp Ile Gln Val Leu Met Gly Ser Leu Val Tyr 
225                 230                 235                 240 


Leu Arg Gln Gly Ile Glu Asn Ser Pro Tyr Val His Leu Leu Asp Ala 
                245                 250                 255     


Asn Gln Trp Ala Asp Ile Cys Asp Ile Phe Thr Arg Asp Ala Cys Ala 
            260                 265                 270         


Leu Leu Gly Leu Ser Val Glu Ser Pro Leu Ser Val Ser Phe Ser Ala 
        275                 280                 285             


Gly Cys Val Ala Leu Pro Ala Leu Ile Asn Ile Lys Ala Val Ile Glu 
    290                 295                 300                 


Gln Arg Gln Cys Thr Gly Val Trp Asn Gln Lys Asp Glu Leu Pro Ile 
305                 310                 315                 320 


Glu Val Asp Leu Gly Lys Lys Cys Trp Tyr His Ser Ile Phe Ala Cys 
                325                 330                 335     


Pro Ile Leu Arg Gln Gln Thr Thr Asp Asn Asn Pro Pro Met Lys Leu 
            340                 345                 350         


Val Cys Gly His Ile Ile Ser Arg Asp Ala Leu Asn Lys Met Phe Asn 
        355                 360                 365             


Gly Ser Lys Leu Lys Cys Pro Tyr Cys Pro Met Glu Gln Ser Pro Gly 
    370                 375                 380                 


Asp Ala Lys Gln Ile Phe Phe 
385                 390     


<210>  7871
<211>  6089
<212>  DNA
<213>  Homosapiens

<400>  7871
ggcccacacc attagagtgg cggcgcgtgt gggcgcccgt cgcgttcctc cgcccgttct     60

cgccgggtcg caccccccac cccgagggtg tacttggtac ggcccgcgcc gcctcctttc    120

ctcgcccggg tggccatccc cctcccccca gtcggcggcg cttggtgccg cccgggagaa    180

ccaggtcatc ggtcggttcc cgtgaaaaca aaaacaatcg gccgcgccgt cgcaggcacc    240

cgaacgtcgc gagcggggcc tggggacgcg gagccgagtg cagcgagcga acgggagcag    300

cggcgactcg ccggggggct agggcgccat ggggcaggcg ggctccggct gcgcggggct    360

cccccggcgc cgcggctagt gcgcccgccg cctcggccgc ctcagcctcc cgcgccgccc    420

gcttggggaa cgaggagcag gacgcggcct cggtggggcc cgggccgaac ggctgcggac    480

acctgggcgc cgaggagccg agcgccgccg cctccggcat ggatcagtgc gtgacggtgg    540

agcgcgagct ggagaaggtg ctgcacaagt tctcaggcta cgggcagctg tgcgagcgcg    600

gcctggagga gctcatcgac tacaccggcg gcctcaagca cgagatcctg cagagccacg    660

gccaagatgc tgaattatca gggacacttt cacttgtttt gacacagtgc tgtaaaagaa    720

taaaggatac tgttcaaaaa ttggcctccg accacaaaga catccacagc agtgtttctc    780

gggttggaaa agccattgat aagaattttg attctgacat tagcagtgtg ggaatagatg    840

gctgctggca ggcagacagc caaaggcttc tcaatgaggt gatggtggag cacttctttc    900

gacaaggaat gctggatgtg gctgaggagc tctgtcagga atctggtctt tctgtagacc    960

caagtcagaa ggaaccattt gtggagttaa atagaatatt agaggcatta aaggtcagag   1020

ttctgagacc tgctctggag tgggcagtgt caaaccggga aatgcttata gctcaaaaca   1080

gctccttgga atttaagcta cacagactgt attttattag cttgttaatg ggtggaacca   1140

caaatcagcg agaggcatta caatatgcta aaaattttca gccatttgcc ctaaatcatc   1200

aaaaagacat tcaggttttg atgggaagcc ttgtgtacct gagacaaggg attgagaact   1260

caccatatgt tcacctactt gatgcaaacc agtgggctga tatctgtgac atctttacac   1320

gggatgcttg tgccctcctg gggctctccg tggagtcccc tctcagtgtc agtttctcag   1380

caggttgtgt ggcgctgcca gctttaatta acatcaaagc cgtgattgaa cagaggcagt   1440

gtactggagt ttggaaccag aaagatgaat tacctattga agtggacctt ggtaaaaagt   1500

gctggtatca ctctatattt gcctgcccca ttcttcgtca gcaaacaaca gataacaatc   1560

cacccatgaa attggtctgt ggtcatatta tatcaagaga tgccctgaat aaaatgttta   1620

atggtagcaa attaaaatgt ccctactgtc caatggaaca aagtccagga gatgccaaac   1680

agatattttt ctgaagagat aactttagtt tgcaatttgt aagtgaaact gaatcgtggg   1740

tgcatttcag aagagaacgt tccatataat gcagctaacc aaggactcct gtgtttctat   1800

aagctaatgc tccagaaact ttgccaacct gttagtgtac acacactgag gggagtgctc   1860

ccggtgaata ttatcatagg gctttattat attcttggtc ttcatttctg atcaagtaaa   1920

tacaccagca gttgtcattc aatgcaggtt tttgtactta attatatggt gattttttta   1980

ctttttaaga gcagaaacgg aaattgacct ccccgccatg tgtttaatat tcctcctgct   2040

tttacttttg tcattttctt gataatcgta agccttgaga gtgtttgtga aaaagtttta   2100

tttcctgtta tgtatacata attaaatgaa aattcttcag aaaaagtttg ataaattgaa   2160

ttgtggttat gaaactaatt tgcattttta tttgcttaag aaagaaagct gtgatagatt   2220

ccagatatgc tttttgatgt tttcctctgc tccagctcca agaagtcagc acacctgcat   2280

tttagctctg catgcagccc cagcaggctg cgtgtttaag aatttcattg tttaactggc   2340

tggtgtgaga agtcttccgt tagcatagag tggaaggagt actattgttt ggttgggttt   2400

ttgtttgttt gttttttgtt tttgctttta ttgccaagag gtgcttgttt taaaagtatg   2460

tttaataaaa tgaaattcta aagttagaag tgttcttaag ttgatattta ctctcttggt   2520

cttggtagcc ctattatatc attgcagaca cagtgttgtg catgtgtgta ttgtatatgt   2580

gcaccagcat caaacattgt gtatctggaa ggaaagcagc atgttccagt tctaaaatgc   2640

agttaccaga cccatcactt taaatcctta aagttagaag ctagcaaatt ttctgtagtg   2700

cagaacgttt attgctgttt ttgtgtttga atagtataat gtttgatgcc tctcttctgc   2760

aaagcgtatc atctcattga ctgtgaatct gtatattatt ctgatggata cagataatga   2820

tcttttctct tgtgaggtat cttcatttat gcactgtcca aaaatagcca tgtgtaagag   2880

tctttctgta tgacgaacta catggaaaag acttctgtgg acataattct gaccgaaacc   2940

catgaagtta cttcagtata agaagaacgt tacacggaaa tcaccaaata ttttgcaact   3000

ttatttcttc tgacatggag tgaacatcaa taggaatact ttcaaagaaa atgaaaacac   3060

agaagcaaag agaaatgtgg cacttcacat tttaaactac agatggactt ggtttgaggg   3120

agggggaatc acagatttgg tgctaagtta attagaaact ggcagcgttt tacagtagta   3180

caccagcctg gatgtttttt ctaaaatgtt tacctgggag agctggggtt tgtttgtgag   3240

gagaaagagt actgtggaaa acctctgctt gagtaccatg tggccaggcc tatgtggatg   3300

gctactccgt gctgtgcggc ttcaccagcg gttgggattg gcccagcttg gagtgcttgt   3360

gtggtccaac ctcagtctgg ccccatagcg acttttgccc catgattctg cttcactgtt   3420

ggaatcctct ttgaagttcc ccctctcttt gctaaagcag tgaaggaaga gaacagagac   3480

aaactctttg gactgtgaaa gagaaggtag agaattccag gcaacagtct gaccaagggt   3540

gtaaaccagt ttattatata tatatttttc ctttgaatta aaacctagag tgttgtattt   3600

ttctttcttt cttttttttt tttttttttt ttaccctttt tctccttagg ccaagtttag   3660

cttattctta tctttccacc caaacaccta cacaacgttt aggcttcctg taaggtttga   3720

atgagacaga tgtactctga aggctggtgg taaatgtgtt tgatgaccag actcttcata   3780

cagtcggctt gggccacttt aaaggacaaa agccagagct cagctttatc cctctcccag   3840

tgctgggagc caaaaaactg ttgacggttt tttgtgcagc tcaagaaaac tttgaaaaga   3900

acatgcttta actgaagcat tggactctgc agctttctgt gtaaggcccg tgtactccca   3960

ctgggcaggg tgaggaccaa aaatctgaaa ctcttatgaa tctgacatat tatatggaaa   4020

ttatatcttg tgaccgtctt caagtgcatg gacttaaaat tcatgagaga ctaaatgtga   4080

gggagaggtg gatttaaaga ggccagacct taaccaaaga tgctgagata cagcattctg   4140

tcccccctgc cctagaaact ccataaatgc tgtcacaacc ctatcatcgc tgatgctttc   4200

tgcatgtcag cagtccagga ggatgctttt tgtctctctt tgcctccact ttacaaaaga   4260

taatatgata gaggcaacgt ttataacagt cacatttaat tataatgtac atcaaaggca   4320

gaatttcaga atggtttctt aaatttcctt gggaaccgtt tccacatatc agttatagac   4380

aaaggccatg ggactatgct aaaccaataa aaccttatta gcaaatcttt agattctgac   4440

ttagccagag catctgagtg ttcaagtaca gttttacagt ggctaaggtt gtctcttgat   4500

cttttttctc cgttgtgtga tcacagatgc tatttctgtt ttattggtga ttatacgaga   4560

cttctaatac ataaatgaac gggtattggt gcctctttat tttaaaaaat ttgaagaaaa   4620

gagccacctc atattcatag ggtgtgtatt ttttgagtgt gagcatttaa ttgaaaataa   4680

gaaagctatg aagtaaatgt taacttctct gtagcagcta atgcatagag acactaaaac   4740

ccacaccaca ttttgtggga aatgaggatc ctgatcctct tttgtcctct ccaggtagtc   4800

tcgcaggtta tgcagcttaa gttcagtctt ctttatgctg cgattgattt ccacctcagt   4860

ggcttagcct ttgggacagt ggatactgca acagccaaga actcttggtt atccgcacaa   4920

gctgctggta gactacatta gccctctggt tttccagctc aacctctgat aaagtggact   4980

gagagccacg ctgctcagtc tgtttcgtca gccgactcag gttattttca gggaaggcat   5040

ggaggcatag tttggttagt ttcatcacta ggatgtataa ggtgacgaca caaaccaaat   5100

acctttcttt catcacttaa ctatacgtac tttatctctg gtaacactag aatgctgtgg   5160

tcttgaggga atgttagcaa ggaacacata gaagatttgg tgtttcataa gcctgtctag   5220

gtgtggcagg ttttgtgtgg tacactgatg tttaccataa gcaggtacaa gcttcatgaa   5280

ccgttcttaa tgaactataa ttgaatagat accaaaaata gaatgacaaa tgtattttaa   5340

tagcagatga ggcagtttta ggatgaattt tccactgttg attttacttc aagacatagc   5400

aagagaaaca aaattttgtt ttcaagacat ttccactgca gtttcaagct gtagtgggca   5460

tatgcttcat ttacttccaa agaggcaaaa gcagctggaa ttggcttaca gcacatgctt   5520

tgtttcatgt tatgggtgag gacctacata cactcttact ttagcagtca cttaaccttc   5580

tccagcaagg cagttgtggg gttcactagg atttagtgcc tgatcttttt tttgggaagg   5640

ggcgggaatg aatgtgttgg ggctgggagg gaagcagaag aaaatgggag tgtgagtgag   5700

tgtgcatgtg tctgaagttc accattgccc ccacctgcac ctagcaagga acaggtgttt   5760

gatgtatttt gctcatgact gcagtatgca tgtatttttt tccttctctg tgttttctaa   5820

acttacacta aaggattcat caaatcatct tgttcagatg gctcaggatt gtatttattt   5880

tgcttacccc gtgctcttgg gttctatagt atttctataa ttatgtaacg agaatagtgt   5940

tgcactgtaa tctatcatat agagctatat gtatggaaaa ttttgatcaa ttttttaaga   6000

aatgtatcct gtttgcaaag gcacagtaaa gttgcatctt atagactata ggcaataaag   6060

ctaacaataa accttattta acacaaacc                                     6089


<210>  7872
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  7872

Met Asp Gln Cys Val Thr Val Glu Arg Glu Leu Glu Lys Val Leu His 
1               5                   10                  15      


Lys Phe Ser Gly Tyr Gly Gln Leu Cys Glu Arg Gly Leu Glu Glu Leu 
            20                  25                  30          


Ile Asp Tyr Thr Gly Gly Leu Lys His Glu Ile Leu Gln Ser His Gly 
        35                  40                  45              


Gln Asp Ala Glu Leu Ser Gly Thr Leu Ser Leu Val Leu Thr Gln Cys 
    50                  55                  60                  


Cys Lys Arg Ile Lys Asp Thr Val Gln Lys Leu Ala Ser Asp His Lys 
65                  70                  75                  80  


Asp Ile His Ser Ser Val Ser Arg Val Gly Lys Ala Ile Asp Lys Asn 
                85                  90                  95      


Phe Asp Ser Asp Ile Ser Ser Val Gly Ile Asp Gly Cys Trp Gln Ala 
            100                 105                 110         


Asp Ser Gln Arg Leu Leu Asn Glu Val Met Val Glu His Phe Phe Arg 
        115                 120                 125             


Gln Gly Met Leu Asp Val Ala Glu Glu Leu Cys Gln Glu Ser Gly Leu 
    130                 135                 140                 


Ser Val Asp Pro Ser Gln Lys Glu Pro Phe Val Glu Leu Asn Arg Ile 
145                 150                 155                 160 


Leu Glu Ala Leu Lys Val Arg Val Leu Arg Pro Ala Leu Glu Trp Ala 
                165                 170                 175     


Val Ser Asn Arg Glu Met Leu Ile Ala Gln Asn Ser Ser Leu Glu Phe 
            180                 185                 190         


Lys Leu His Arg Leu Tyr Phe Ile Ser Leu Leu Met Gly Gly Thr Thr 
        195                 200                 205             


Asn Gln Arg Glu Ala Leu Gln Tyr Ala Lys Asn Phe Gln Pro Phe Ala 
    210                 215                 220                 


Leu Asn His Gln Lys Asp Ile Gln Val Leu Met Gly Ser Leu Val Tyr 
225                 230                 235                 240 


Leu Arg Gln Gly Ile Glu Asn Ser Pro Tyr Val His Leu Leu Asp Ala 
                245                 250                 255     


Asn Gln Trp Ala Asp Ile Cys Asp Ile Phe Thr Arg Asp Ala Cys Ala 
            260                 265                 270         


Leu Leu Gly Leu Ser Val Glu Ser Pro Leu Ser Val Ser Phe Ser Ala 
        275                 280                 285             


Gly Cys Val Ala Leu Pro Ala Leu Ile Asn Ile Lys Ala Val Ile Glu 
    290                 295                 300                 


Gln Arg Gln Cys Thr Gly Val Trp Asn Gln Lys Asp Glu Leu Pro Ile 
305                 310                 315                 320 


Glu Val Asp Leu Gly Lys Lys Cys Trp Tyr His Ser Ile Phe Ala Cys 
                325                 330                 335     


Pro Ile Leu Arg Gln Gln Thr Thr Asp Asn Asn Pro Pro Met Lys Leu 
            340                 345                 350         


Val Cys Gly His Ile Ile Ser Arg Asp Ala Leu Asn Lys Met Phe Asn 
        355                 360                 365             


Gly Ser Lys Leu Lys Cys Pro Tyr Cys Pro Met Glu Gln Ser Pro Gly 
    370                 375                 380                 


Asp Ala Lys Gln Ile Phe Phe 
385                 390     


<210>  7873
<211>  6324
<212>  DNA
<213>  Homosapiens

<400>  7873
ggcccacacc attagagtgg cggcgcgtgt gggcgcccgt cgcgttcctc cgcccgttct     60

cgccgggtcg caccccccac cccgagggtg tacttggtac ggcccgcgcc gcctcctttc    120

ctcgcccggg tggccatccc cctcccccca gtcggcggcg cttggtgccg cccgggagaa    180

ccaggtcatc ggtcggttcc cgtgaaaaca aaaacaatcg gccgcgccgt cgcaggcacc    240

cgaacgtcgc gagcggggcc tggggacgcg gagccgagtg cagcgagcga acgggagcag    300

cggcgactcg ccggggggct agggcgccat ggggcaggcg ggctccggct gcgcggggct    360

cccccggcgc cgcggctagt gcgcccgccg cctcggccgc ctcagcctcc cgcgccgccc    420

gcttggggaa cgaggagcag gacgcggcct cggtggggcc cgggccgaac ggctgcggac    480

acctgggcgc cgaggagccg agcgccgccg cctccggcat ggatcagtgc gtgacggtgg    540

agcgcgagct ggagaaggtg ctgcacaagt tctcaggcta cgggcagctg tgcgagcgcg    600

gcctggagga gctcatcgac tacaccggcg gcctcaagca cgagatcctg cagagccacg    660

gccaagatgc tgaattatca gggacacttt cacttgtttt gacacagtgc tgtaaaagaa    720

taaaggatac tgttcaaaaa ttggcctccg accacaaaga catccacagc agtgtttctc    780

gggttggaaa agccattgat aagaattttg attctgacat tagcagtgtg ggaatagatg    840

gctgctggca ggcagacagc caaaggcttc tcaatgaggt gatggtggag cacttctttc    900

gacaaggaat gctggatgtg gctgaggagc tctgtcagga atctggtctt tctgtagacc    960

caagtcagaa ggaaccattt gtggagttaa atagaatatt agaggcatta aaggtcagag   1020

ttctgagacc tgctctggag tgggcagtgt caaaccggga aatgcttata gctcaaaaca   1080

gctccttgga atttaagcta cacagactgt attttattag cttgttaatg ggtggaacca   1140

caaatcagcg agaggcatta caatatgcta aaaattttca gccatttgcc ctaaatcatc   1200

aaaaagacat tcaggttttg atgggaagcc ttgtgtacct gagacaaggg attgagaact   1260

caccatatgt tcacctactt gatgcaaacc agtgggctga tatctgtgac atctttacac   1320

gggatgcttg tgccctcctg gggctctccg tggagtcccc tctcagtgtc agtttctcag   1380

caggttgtgt ggcgctgcca gctttaatta acatcaaagc cgtgattgaa cagaggcagt   1440

gtactggagt ttggaaccag aaagatgaat tacctattga agtggacctt ggtaaaaagt   1500

gctggtatca ctctatattt gcctgcccca ttcttcgtca gcaaacaaca gataacaatc   1560

cacccatgaa attggtctgt ggtcatatta tatcaagaga tgccctgaat aaaatgttta   1620

atggtagcaa attaaaatgt ccctactgtc caatggaaca aagtccagga gatgccaaac   1680

agatattttt ctgaagagat aactttagtt tgcaatttgt aagtgaaact gaatcgtggg   1740

tgcatttcag aagagaacgt tccatataat gcagctaacc aaggactcct gtgtttctat   1800

aagctaatgc tccagaaact ttgccaacct gttagtgtac acacactgag gggagtgctc   1860

ccggtgaata ttatcatagg gctttattat attcttggtc ttcatttctg atcaagtaaa   1920

tacaccagca gttgtcattc aatgcaggtt tttgtactta attatatggt gattttttta   1980

ctttttaaga gcagaaacgg aaattgacct ccccgccatg tgtttaatat tcctcctgct   2040

tttacttttg tcattttctt gataatcgta agccttgaga gtgtttgtga aaaagtttta   2100

tttcctgtta tgtatacata attaaatgaa aattcttcag aaaaagtttg ataaattgaa   2160

ttgtggttat gaaactaatt tgcattttta tttgcttaag aaagaaagct gtgatagatt   2220

ccagatatgc tttttgatgt tttcctctgc tccagctcca agaagtcagc acacctgcat   2280

tttagctctg catgcagccc cagcaggctg cgtgtttaag aatttcattg tttaactggc   2340

tggtgtgaga agtcttccgt tagcatagag tggaaggagt actattgttt ggttgggttt   2400

ttgtttgttt gttttttgtt tttgctttta ttgccaagag gtgcttgttt taaaagtatg   2460

tttaataaaa tgaaattcta aagttagaag tgttcttaag ttgatattta ctctcttggt   2520

cttggtagcc ctattatatc attgcagaca cagtgttgtg catgtgtgta ttgtatatgt   2580

gcaccagcat caaacattgt gtatctggaa ggaaagcagc atgttccagt tctaaaatgc   2640

agttaccaga cccatcactt taaatcctta aagttagaag ctagcaaatt ttctgtagtg   2700

cagaacgttt attgctgttt ttgtgtttga atagtataat gtttgatgcc tctcttctgc   2760

aaagcgtatc atctcattga ctgtgaatct gtatattatt ctgatggata cagataatga   2820

tcttttctct tgtgaggtat cttcatttat gcactgtcca aaaatagcca tgtgtaagag   2880

tctttctgta tgacgaacta catggaaaag acttctgtgg acataattct gaccgaaacc   2940

catgaagtta cttcagtata agaagaacgt tacacggaaa tcaccaaata ttttgcaact   3000

ttatttcttc tgacatggag tgaacatcaa taggaatact ttcaaagaaa atgaaaacac   3060

agaagcaaag agaaatgtgg cacttcacat tttaaactac agatggactt ggtttgaggg   3120

agggggaatc acagatttgg tgctaagtta attagaaact ggcagcgttt tacagtagta   3180

caccagcctg gatgtttttt ctaaaatgtt tacctgggag agctggggtt tgtttgtgag   3240

gagaaagagt actgtggaaa acctctgctt gagtaccatg tggccaggcc tatgtggatg   3300

gctactccgt gctgtgcggc ttcaccagcg gttgggattg gcccagcttg gagtgcttgt   3360

gtggtccaac ctcagtctgg ccccatagcg acttttgccc catgattctg cttcactgtt   3420

ggaatcctct ttgaagttcc ccctctcttt gctaaagcag tgaaggaaga gaacagagac   3480

aaactctttg gactgtgaaa gagaaggtag agaattccag gcaacagtct gaccaagggt   3540

gtaaaccagt ttattatata tatatttttc ctttgaatta aaacctagag tgttgtattt   3600

ttctttcttt cttttttttt tttttttttt ttaccctttt tctccttagg ccaagtttag   3660

cttattctta tctttccacc caaacaccta cacaacgttt aggcttcctg taaggtttga   3720

atgagacaga tgtactctga aggctggtgg taaatgtgtt tgatgaccag actcttcata   3780

cagtcggctt gggccacttt aaaggacaaa agccagagct cagctttatc cctctcccag   3840

tgctgggagc caaaaaactg ttgacggttt tttgtgcagc tcaagaaaac tttgaaaaga   3900

acatgcttta actgaagcat tggactctgc agctttctgt gtaaggcccg tgtactccca   3960

ctgggcaggg tgaggaccaa aaatctgaaa ctcttatgaa tctgacatat tatatggaaa   4020

ttatatcttg tgaccgtctt caagtgcatg gacttaaaat tcatgagaga ctaaatgtga   4080

gggagaggtg gatttaaaga ggccagacct taaccaaaga tgctgagata cagcattctg   4140

tcccccctgc cctagaaact ccataaatgc tgtcacaacc ctatcatcgc tgatgctttc   4200

tgcatgtcag cagtccagga ggatgctttt tgtctctctt tgcctccact ttacaaaaga   4260

taatatgata gaggcaacgt ttataacagt cacatttaat tataatgtac atcaaaggca   4320

gaatttcaga atggtttctt aaatttcctt gggaaccgtt tccacatatc agttatagac   4380

aaaggccatg ggactatgct aaaccaataa aaccttatta gcaaatcttt agattctgac   4440

ttagccagag catctgagtg ttcaagtaca gttttacagt ggctaaggtt gtctcttgat   4500

cttttttctc cgttgtgtga tcacagatgc tatttctgtt ttattggtga ttatacgaga   4560

cttctaatac ataaatgaac gggtattggt gcctctttat tttaaaaaat ttgaagaaaa   4620

gagccacctc atattcatag ggtgtgtatt ttttgagtgt gagcatttaa ttgaaaataa   4680

gaaagctatg aagtaaatgt taacttctct gtagcagcta atgcatagag acactaaaac   4740

ccacaccaca ttttgtggga aatgaggatc ctgatcctct tttgtcctct ccaggtagtc   4800

tcgcaggtta tgcagcttaa gttcagtctt ctttatgctg cgattgattt ccacctcagt   4860

ggcttagcct ttgggacagt ggatactgca acagccaaga actcttggtt atccgcacaa   4920

gctgctggta gactacatta gccctctggt tttccagctc aacctctgat aaagtggact   4980

gagagccacg ctgctcagtc tgtttcgtca gccgactcag gttattttca gggaaggcat   5040

ggaggcatag tttggttagt ttcatcacta ggatgtataa ggtgacgaca caaaccaaat   5100

acctttcttt catcacttaa ctatacgtac tttatctctg gtaacactag aatgctgtgg   5160

tcttgaggga atgttagcaa ggaacacata gaagatttgg tgtttcataa gcctgtctag   5220

gtgtggcagg ttttgtgtgg tacactgatg tttaccataa gcaggtacaa gcttcatgaa   5280

ccgttcttaa tgaactataa ttgaatagat accaaaaata gaatgacaaa tgtattttaa   5340

tagcagatga ggcagtttta ggatgaattt tccactgttg attttacttc aagacatagc   5400

aagagaaaca aaattttgtt ttcaagacat ttccactgca gtttcaagct gtagtgggca   5460

tatgcttcat ttacttccaa agaggcaaaa gcagctggaa ttggcttaca gcacatgctt   5520

tgtttcatgt tatgggtgag gacctacata cactcttact ttagcagtca cttaaccttc   5580

tccagcaagg cagttgtggg gttcactagg atttagtgcc tgatcttttt tttgggaagg   5640

ggcgggaatg aatgtgttgg ggctgggagg gaagcagaag aaaatgggag tgtgagtgag   5700

tgtgcatgtg tctgaagttc accattgccc ccacctgcac ctagcaagga acaggtgttt   5760

gatgtatttt gctcatgact gcagtatgca tgtatttttt tccttctctg tgttttctaa   5820

acttacacta aaggattcat caaatcatct tgttcagatg gctcaggatt gtatttattt   5880

tgcttacccc gtgctcttgg gttctatagt atttctataa ttatgtaacg agaatagtgt   5940

tgcactgtaa tctatcatat agagctatat gtatggaaaa ttttgatcaa ttttttaaga   6000

aatgtatcct gtttgcaaag gcacagtaaa gttgcatctt atagactata ggcaataaag   6060

ctaacaataa accttattta acacaaacca catccatatc ctctgttcat ttgattttgg   6120

aaaaagtagc atatccagta gtttcaggga attcatttta actttaagaa ttctgatata   6180

tttaatttat aaatttcgga ctgatataat agagttttgg aaaactataa gaaatgcttt   6240

gttaatgtgt gtattcctat gtaaaacaca tggcttttcc tgtgtatatt tttaaaaatt   6300

aaagaaatgc acatttaaaa agtg                                          6324


<210>  7874
<211>  391
<212>  PRT
<213>  Homosapiens

<400>  7874

Met Asp Gln Cys Val Thr Val Glu Arg Glu Leu Glu Lys Val Leu His 
1               5                   10                  15      


Lys Phe Ser Gly Tyr Gly Gln Leu Cys Glu Arg Gly Leu Glu Glu Leu 
            20                  25                  30          


Ile Asp Tyr Thr Gly Gly Leu Lys His Glu Ile Leu Gln Ser His Gly 
        35                  40                  45              


Gln Asp Ala Glu Leu Ser Gly Thr Leu Ser Leu Val Leu Thr Gln Cys 
    50                  55                  60                  


Cys Lys Arg Ile Lys Asp Thr Val Gln Lys Leu Ala Ser Asp His Lys 
65                  70                  75                  80  


Asp Ile His Ser Ser Val Ser Arg Val Gly Lys Ala Ile Asp Lys Asn 
                85                  90                  95      


Phe Asp Ser Asp Ile Ser Ser Val Gly Ile Asp Gly Cys Trp Gln Ala 
            100                 105                 110         


Asp Ser Gln Arg Leu Leu Asn Glu Val Met Val Glu His Phe Phe Arg 
        115                 120                 125             


Gln Gly Met Leu Asp Val Ala Glu Glu Leu Cys Gln Glu Ser Gly Leu 
    130                 135                 140                 


Ser Val Asp Pro Ser Gln Lys Glu Pro Phe Val Glu Leu Asn Arg Ile 
145                 150                 155                 160 


Leu Glu Ala Leu Lys Val Arg Val Leu Arg Pro Ala Leu Glu Trp Ala 
                165                 170                 175     


Val Ser Asn Arg Glu Met Leu Ile Ala Gln Asn Ser Ser Leu Glu Phe 
            180                 185                 190         


Lys Leu His Arg Leu Tyr Phe Ile Ser Leu Leu Met Gly Gly Thr Thr 
        195                 200                 205             


Asn Gln Arg Glu Ala Leu Gln Tyr Ala Lys Asn Phe Gln Pro Phe Ala 
    210                 215                 220                 


Leu Asn His Gln Lys Asp Ile Gln Val Leu Met Gly Ser Leu Val Tyr 
225                 230                 235                 240 


Leu Arg Gln Gly Ile Glu Asn Ser Pro Tyr Val His Leu Leu Asp Ala 
                245                 250                 255     


Asn Gln Trp Ala Asp Ile Cys Asp Ile Phe Thr Arg Asp Ala Cys Ala 
            260                 265                 270         


Leu Leu Gly Leu Ser Val Glu Ser Pro Leu Ser Val Ser Phe Ser Ala 
        275                 280                 285             


Gly Cys Val Ala Leu Pro Ala Leu Ile Asn Ile Lys Ala Val Ile Glu 
    290                 295                 300                 


Gln Arg Gln Cys Thr Gly Val Trp Asn Gln Lys Asp Glu Leu Pro Ile 
305                 310                 315                 320 


Glu Val Asp Leu Gly Lys Lys Cys Trp Tyr His Ser Ile Phe Ala Cys 
                325                 330                 335     


Pro Ile Leu Arg Gln Gln Thr Thr Asp Asn Asn Pro Pro Met Lys Leu 
            340                 345                 350         


Val Cys Gly His Ile Ile Ser Arg Asp Ala Leu Asn Lys Met Phe Asn 
        355                 360                 365             


Gly Ser Lys Leu Lys Cys Pro Tyr Cys Pro Met Glu Gln Ser Pro Gly 
    370                 375                 380                 


Asp Ala Lys Gln Ile Phe Phe 
385                 390     


<210>  7875
<211>  4798
<212>  DNA
<213>  Homosapiens

<400>  7875
agttggctcg gcggcagcgg agcggccgga gctgcggtgc ggaccggggc cgcgcggcgt     60

ggcgcgggga gcggcggcgg cggcagagcc agagcaacat ggcgccggtg ggcgggggcg    120

ggcgcccggt cggcggaccg gcccgcgggc gcctcctcct ggcggcgccg gtgctgctgg    180

tgctgctgtg ggcgctgggg gcccggggcc agggcagccc ccagcagggc acgatcgtgg    240

gcatgaggct ggcgagctgc aacaagtcgt gtgggacgaa cccggatggc atcatcttcg    300

tgtccgaggg cagcaccgtg aacctgaggc tgtacggcta cagcctgggc aacatctcca    360

gcaacctgat ctccttcacc gaggtggacg atgccgagac cctccacaag tccaccagct    420

gcctcgagct caccaaggac ctggtcgtcc agcagctggt caacgtgagc cgcgggaaca    480

cgtccggcgt gctggtggtg ctcaccaagt tcctccggag gagcgagagc atgaagctgt    540

atgcactgtg cacccgggcc cagcccgacg ggccctggct gaagtggacg gacaaggact    600

cactgctctt catggtggag gagcctggga ggttcctgcc tctctggctg cacattctcc    660

taattacggt gctgctggtg ctgtcgggca tattttctgg cctcaacctc gggcttatgg    720

ccctggaccc catggagctg cgcatcgtgc agaactgtgg caccgagaag gagaggcgct    780

atgcccgcaa gattgagccc atccggcgca agggcaacta ccttctctgc tcgttgctcc    840

tagggaacgt gctggtcaac acctccctca caatccttct agacaacctc atcgggtccg    900

gcctcatggc ggtggcctcc tccaccattg gcattgtcat ctttggggag atcctacctc    960

aggccctgtg ctcccgacat gggctggctg tgggtgccaa caccatcctt ctcaccaaat   1020

tctttatgct actcaccttc cccctcagtt ttcccattag caagctcctg gacttttttc   1080

tgggccagga gattcgcact gtttacaacc gggagaagct gatggagatg ttgaaggtga   1140

cggagcccta taatgacctc gtgaaagagg agctcaatat gatccagggt gccctggaac   1200

tacggaccaa aactgtagag gatatcatga cccagctcca ggactgcttc atgatccgca   1260

gcgatgccat cctggacttc aacaccatgt cggagataat ggaaagcggc tatactcgca   1320

tcccggtgtt cgaagacgag cagtccaata ttgtagatat tctctacgtc aaagacttgg   1380

cctttgtgga ccccgatgac tgcacccccc tcaagactat cactcgcttc tataaccacc   1440

cggtgcactt tgtcttccat gacaccaagt tggatgccat gctggaggag ttcaagaagg   1500

ggaagtccca cctggccatc gtgcagaagg taaacaacga gggtgagggt gaccccttct   1560

acgaggtcct gggcctggtc accctggagg acgtgatcga ggagatcatc aagtcggaga   1620

tcctggacga gtccgacatg tacactgaca accgaagccg gaagcgggtg tctgagaaga   1680

acaagcgtga cttctctgcc ttcaaggatg cggacaatga gctcaaagtg aaaatctccc   1740

cgcagctcct cctggccgct catcgcttcc tagccacaga ggtctctcag tttagcccct   1800

ccctgatatc agagaagatc ctgctgcggc tactcaagta cccagatgtc attcaggaac   1860

tcaagtttga cgagcacaat aagtactacg cccgccatta cctgtacacc cgaaataagc   1920

cggccgacta cttcatcctc atcctgcagg ggaaggtgga ggtggaggca gggaaggaga   1980

acatgaagtt tgagacgggc gccttctcct actatgggac tatggccctg acctcggtcc   2040

cctccgaccg ttccccagca caccccaccc cactcagccg ctcagcctcc ctcagttacc   2100

cagaccgcac agacgtctca actgcagcaa ccttggcagg cagcagcaac cagtttggca   2160

gctctgtcct gggccagtac atctctgact tcagcgtccg ggcactcgtg gacttgcagt   2220

acatcaagat cactcggcag cagtaccaga acgggctgct ggcttctcgc atggagaaca   2280

gccctcagtt tcccatagac gggtgcacca cccacatgga gaacttggcc gagaagtctg   2340

agctgcctgt ggtggacgag accacaactc ttctcaacga gcgtaactcc ttgctgcaca   2400

aagcctccca cgagaatgcc atctgacagg agggcccggg gccccctgcc caccctgcgg   2460

gggcctcccc agtgggccca catgaagaga gggaacctgt tagtccagaa aggatacgga   2520

tagatagcct gtctgactga acagccagat ggcccccagc ctatggggga tctggcctct   2580

gccagggacc tctgagtagc tctgaggtgg cactgtccag ccctggatag ggggggcagt   2640

gggccagcta ccgtaagcaa aggctgtttt ttactgagag aatttctaaa gtaggctcat   2700

cacttttttt taaatatcat tttgggaagg gaagacaggg ttaaggaact ttatttaaaa   2760

aaaaaatatt tttttcctaa aaactataaa agaggaaggg tttcttgtcc cgggaagcaa   2820

cggacataat ctgttcccag ccatggcctt ccagcttgtg tccctgattc agggagctct   2880

cccttcctcc tcctcctcct cctccggagg tgggatccca gagcctgcca gtggaggctt   2940

atctgttggg aggaagacag ctcttcacag aagcaaagaa caaaatggca tggagatcag   3000

ctgcctgagc acctgcgctg tagcttatct gacaacgctg aggccacgag ctcctgggta   3060

gctgtgatca gggacatgat aatctgagct atgcagagga gcacatctgt tgtcaactgc   3120

tgtacccaga aatctagaac tctgccgaca gcctctcctg gtgagtcggg actcagctga   3180

ggacacatcc ccaccctgcc tcccatctgg ccctttggac aactggccct ttgtgacagg   3240

gctgactcaa gtgttaggca gggtctcagg cctttgattg ctcacccctg ctccccaggc   3300

cctgccctca cttttaccaa aggttctccc tcggcgggag ggcatctgtg ttggaggtga   3360

tttgtctggg ttcttccttt tggttccaga aggaactgtc agtcatcagc atctgcgttg   3420

ttagcagtca gtaccacccc cgccccacaa tgacagtcaa ggctgacttg ttgactgaag   3480

cctttttccc agacccctta tttcgaatcc ccaagcttca gtccctcttg ggggtggaga   3540

caagaggaca tgtgggaagc cacggaagca ggttctttat gtcctctcct ctgtggctgg   3600

caaggctcac ctggccttat ccacccactt atggaacctc aggagaggag ggctcctcct   3660

aaaggcatgc agcttgcagc ccctctttct cacacgtgtg atcctagcgt gagaggtcat   3720

cctgcccttg ctgaagttag tagtactgta ctaagagctc tgccctcatg tgaattcctg   3780

ccctggcgcc tcttccctgg ggctgaatca ggccctgctg caaaactcca ggcttcccag   3840

ggttggggag gctgtgggac caaggtccat gttggtcctt ccactgggtg cagcaggagc   3900

tgggtcccga gagcctggca ggtgaaactc tgcaggcctt ccgcctgatt attatttatt   3960

cactcctttc ctcaccccaa gtgccctgct ctccaggtgc ctagagtatc ctaactctta   4020

ggaccaggga ttgtcttgca ccaagtatgc ctacccctgg ccagtctgag gtctcctagc   4080

catagaactg actcctggaa gcctggagag aaggtggtga cacccatggg ttctcaactg   4140

taaggaaaaa agacaccaga cttttgttcc ctagtggggg aaagccctta gtcttgtaca   4200

ggagcagctt gctcccaagt ccttttggaa gctggcagag ctatattcct gacagccctg   4260

actgccaggt agagcaaaag acattggtgg gggtatgtga agcaaaaggg gcaggtgcac   4320

acacctccac agtgacctct gtgcacacgg ttaccaccaa ctggctggcc ctcctcctct   4380

tccctggccc attgatcatc ccttctcaca gagggtcatc attatttcca aatattgttt   4440

gtctgatgac ttcctcttcc cagtgcaatt tttcccttcc tatttcaacc tctggttcct   4500

gggatgagcc ataccctgga actggcccac ccactgtgtc ttccacgtaa gggagacctt   4560

tgcaaagggc atccaaatgg gtaggcaggt gacagccgcc gtatttattt tgcataatat   4620

tttaatttgt atatttttgt gatttatttt ggcgttatga gtttgactct cggggagttt   4680

tgttgttatg actcttgtgt cttttgtcac aaaacaatga tatttgctaa acgatatatg   4740

gaatttattt ttgattggta ataaaaaatc aaatatgtat aaatcctggt gaatctac     4798


<210>  7876
<211>  775
<212>  PRT
<213>  Homosapiens

<400>  7876

Met Ala Pro Val Gly Gly Gly Gly Arg Pro Val Gly Gly Pro Ala Arg 
1               5                   10                  15      


Gly Arg Leu Leu Leu Ala Ala Pro Val Leu Leu Val Leu Leu Trp Ala 
            20                  25                  30          


Leu Gly Ala Arg Gly Gln Gly Ser Pro Gln Gln Gly Thr Ile Val Gly 
        35                  40                  45              


Met Arg Leu Ala Ser Cys Asn Lys Ser Cys Gly Thr Asn Pro Asp Gly 
    50                  55                  60                  


Ile Ile Phe Val Ser Glu Gly Ser Thr Val Asn Leu Arg Leu Tyr Gly 
65                  70                  75                  80  


Tyr Ser Leu Gly Asn Ile Ser Ser Asn Leu Ile Ser Phe Thr Glu Val 
                85                  90                  95      


Asp Asp Ala Glu Thr Leu His Lys Ser Thr Ser Cys Leu Glu Leu Thr 
            100                 105                 110         


Lys Asp Leu Val Val Gln Gln Leu Val Asn Val Ser Arg Gly Asn Thr 
        115                 120                 125             


Ser Gly Val Leu Val Val Leu Thr Lys Phe Leu Arg Arg Ser Glu Ser 
    130                 135                 140                 


Met Lys Leu Tyr Ala Leu Cys Thr Arg Ala Gln Pro Asp Gly Pro Trp 
145                 150                 155                 160 


Leu Lys Trp Thr Asp Lys Asp Ser Leu Leu Phe Met Val Glu Glu Pro 
                165                 170                 175     


Gly Arg Phe Leu Pro Leu Trp Leu His Ile Leu Leu Ile Thr Val Leu 
            180                 185                 190         


Leu Val Leu Ser Gly Ile Phe Ser Gly Leu Asn Leu Gly Leu Met Ala 
        195                 200                 205             


Leu Asp Pro Met Glu Leu Arg Ile Val Gln Asn Cys Gly Thr Glu Lys 
    210                 215                 220                 


Glu Arg Arg Tyr Ala Arg Lys Ile Glu Pro Ile Arg Arg Lys Gly Asn 
225                 230                 235                 240 


Tyr Leu Leu Cys Ser Leu Leu Leu Gly Asn Val Leu Val Asn Thr Ser 
                245                 250                 255     


Leu Thr Ile Leu Leu Asp Asn Leu Ile Gly Ser Gly Leu Met Ala Val 
            260                 265                 270         


Ala Ser Ser Thr Ile Gly Ile Val Ile Phe Gly Glu Ile Leu Pro Gln 
        275                 280                 285             


Ala Leu Cys Ser Arg His Gly Leu Ala Val Gly Ala Asn Thr Ile Leu 
    290                 295                 300                 


Leu Thr Lys Phe Phe Met Leu Leu Thr Phe Pro Leu Ser Phe Pro Ile 
305                 310                 315                 320 


Ser Lys Leu Leu Asp Phe Phe Leu Gly Gln Glu Ile Arg Thr Val Tyr 
                325                 330                 335     


Asn Arg Glu Lys Leu Met Glu Met Leu Lys Val Thr Glu Pro Tyr Asn 
            340                 345                 350         


Asp Leu Val Lys Glu Glu Leu Asn Met Ile Gln Gly Ala Leu Glu Leu 
        355                 360                 365             


Arg Thr Lys Thr Val Glu Asp Ile Met Thr Gln Leu Gln Asp Cys Phe 
    370                 375                 380                 


Met Ile Arg Ser Asp Ala Ile Leu Asp Phe Asn Thr Met Ser Glu Ile 
385                 390                 395                 400 


Met Glu Ser Gly Tyr Thr Arg Ile Pro Val Phe Glu Asp Glu Gln Ser 
                405                 410                 415     


Asn Ile Val Asp Ile Leu Tyr Val Lys Asp Leu Ala Phe Val Asp Pro 
            420                 425                 430         


Asp Asp Cys Thr Pro Leu Lys Thr Ile Thr Arg Phe Tyr Asn His Pro 
        435                 440                 445             


Val His Phe Val Phe His Asp Thr Lys Leu Asp Ala Met Leu Glu Glu 
    450                 455                 460                 


Phe Lys Lys Gly Lys Ser His Leu Ala Ile Val Gln Lys Val Asn Asn 
465                 470                 475                 480 


Glu Gly Glu Gly Asp Pro Phe Tyr Glu Val Leu Gly Leu Val Thr Leu 
                485                 490                 495     


Glu Asp Val Ile Glu Glu Ile Ile Lys Ser Glu Ile Leu Asp Glu Ser 
            500                 505                 510         


Asp Met Tyr Thr Asp Asn Arg Ser Arg Lys Arg Val Ser Glu Lys Asn 
        515                 520                 525             


Lys Arg Asp Phe Ser Ala Phe Lys Asp Ala Asp Asn Glu Leu Lys Val 
    530                 535                 540                 


Lys Ile Ser Pro Gln Leu Leu Leu Ala Ala His Arg Phe Leu Ala Thr 
545                 550                 555                 560 


Glu Val Ser Gln Phe Ser Pro Ser Leu Ile Ser Glu Lys Ile Leu Leu 
                565                 570                 575     


Arg Leu Leu Lys Tyr Pro Asp Val Ile Gln Glu Leu Lys Phe Asp Glu 
            580                 585                 590         


His Asn Lys Tyr Tyr Ala Arg His Tyr Leu Tyr Thr Arg Asn Lys Pro 
        595                 600                 605             


Ala Asp Tyr Phe Ile Leu Ile Leu Gln Gly Lys Val Glu Val Glu Ala 
    610                 615                 620                 


Gly Lys Glu Asn Met Lys Phe Glu Thr Gly Ala Phe Ser Tyr Tyr Gly 
625                 630                 635                 640 


Thr Met Ala Leu Thr Ser Val Pro Ser Asp Arg Ser Pro Ala His Pro 
                645                 650                 655     


Thr Pro Leu Ser Arg Ser Ala Ser Leu Ser Tyr Pro Asp Arg Thr Asp 
            660                 665                 670         


Val Ser Thr Ala Ala Thr Leu Ala Gly Ser Ser Asn Gln Phe Gly Ser 
        675                 680                 685             


Ser Val Leu Gly Gln Tyr Ile Ser Asp Phe Ser Val Arg Ala Leu Val 
    690                 695                 700                 


Asp Leu Gln Tyr Ile Lys Ile Thr Arg Gln Gln Tyr Gln Asn Gly Leu 
705                 710                 715                 720 


Leu Ala Ser Arg Met Glu Asn Ser Pro Gln Phe Pro Ile Asp Gly Cys 
                725                 730                 735     


Thr Thr His Met Glu Asn Leu Ala Glu Lys Ser Glu Leu Pro Val Val 
            740                 745                 750         


Asp Glu Thr Thr Thr Leu Leu Asn Glu Arg Asn Ser Leu Leu His Lys 
        755                 760                 765             


Ala Ser His Glu Asn Ala Ile 
    770                 775 


<210>  7877
<211>  1480
<212>  DNA
<213>  Homosapiens

<400>  7877
ggtgatgttc tgtgcccttt gagtttacct tacttttgca gattacagag taagccgcca     60

gcagaagcaa taaagacatt actgggcctt tgcactgcaa catcatgcct ctgaagaaaa    120

aaaaagtgca aacattacaa tagattcagc tcctttagtt ctcacttctg tctccacgtc    180

aagataaaat actgacattg aaatagaatg gatgacatgc ttgaaatgag tcatgtgcct    240

gaaaagtcat taacaaacaa cagttccaga gaaaagccag gaaaaactcc ccatggattt    300

agagacagag ctctcacctt caacaggtta ctttttcctt gtctcaggct tccttggaaa    360

acaacctata actaactttc tgggagtaaa gcttcaggtg gaagaacaat tggatcaaac    420

ttggaaaaca tgcccccagt ttgtctactc cattgaactt tgcatgcttg gagcccctgg    480

cctcagcaca ctcaatcgca caagccagcc tgcagcacct gtacagcacc atgggagtcc    540

cctgcagagc tgcaactttg agagtgggta tagtgacgta actcaggttc ttcaagggat    600

gaacactcca actttgaaac cactagcctg taggtgtgga cgaaaaggca gctgcatgtt    660

ataaaacaat attactcata cttttggatc aagcttcttt cagtcccatg ggtagggagg    720

aggggcaatt tgctgaagcc cactgccctt ccagtactca caagccaagg gccctatggg    780

atctgtttca caggactcat gcttatggca gctgagcaca tctgtcctgt atgtctgcca    840

gcagccacgt ccctctcact cctgtgacga cagccttgac tatatttaga aattccattt    900

ctgattgcat ttcactgctg aatggtccta gaatccttta ttgcccttgt cccatcacaa    960

gagacagcca gccacagcca cttttatctc aacaacatac tgaatactga cagaacaaac   1020

aggcaagttg tagattcacc aggatttata catatttgat tttttattac caatcaaaaa   1080

taaattccat atatcgttta gcaaatatca ttgttttgtg acaaaagaca caagagtcat   1140

aacaacaaaa ctccccgaga gtcaaactca taacgccaaa ataaatcaca aaaatataca   1200

aattaaaata ttatgcaaaa taaatacggc ggctgtcacc tgcctaccca tttggatgcc   1260

ctttgcaaag gtctccctta cgtggaagac acagtgggtg ggccagttcc agggtatggc   1320

tcatcccagg aaccagaggt tgaaatagga agggaaaaat tgcactggga agaggaagtc   1380

atcagacaaa caatatttgg aaataatgat gaccctctgt gagaagggat gatcaatggg   1440

ccagggaaga ggaggagggc cagccagttg gtggtaaccg                         1480


<210>  7878
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  7878

Met Asp Leu Glu Thr Glu Leu Ser Pro Ser Thr Gly Tyr Phe Phe Leu 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Lys Gln Pro Ile Thr Asn Phe Leu Gly Val 
            20                  25                  30          


Lys Leu Gln Val Glu Glu Gln Leu Asp Gln Thr Trp Lys Thr Cys Pro 
        35                  40                  45              


Gln Phe Val Tyr Ser Ile Glu Leu Cys Met Leu Gly Ala Pro Gly Leu 
    50                  55                  60                  


Ser Thr Leu Asn Arg Thr Ser Gln Pro Ala Ala Pro Val Gln His His 
65                  70                  75                  80  


Gly Ser Pro Leu Gln Ser Cys Asn Phe Glu Ser Gly Tyr Ser Asp Val 
                85                  90                  95      


Thr Gln Val Leu Gln Gly Met Asn Thr Pro Thr Leu Lys Pro Leu Ala 
            100                 105                 110         


Cys Arg Cys Gly Arg Lys Gly Ser Cys Met Leu 
        115                 120             


<210>  7879
<211>  679
<212>  DNA
<213>  Homosapiens

<400>  7879
ggtgatgttc tgtgcccttt gagtttacct tacttttgca gattacagag taagccgcca     60

gcagaagcaa taaagacatt actgggcctt tgcactgcaa catcatgcct ctgaagaaaa    120

aaaaagtgca aacattacaa tagattcagc tcctttagtt ctcacttctg tctccacgtc    180

aagataaaat actgacattg aaatagaatg gatgacatgc ttgaaatgag tcatgtgcct    240

gaaaagtcat taacaaacaa cagttccaga gaaaagccag gaaaaactcc ccatggattt    300

agagacagag ctctcacctt caacaggtta ctttttcctt gtctcaggct tccttggaaa    360

acaacctata actaactttc tgggagtaaa gcttcaggtg gaagaacaat tggatcaaac    420

ttggaaaaca tgcccccagt ttgtctactc cattgaactt tgcatgcttg gagcccctgg    480

cctcagcaca ctcaatcgca caagccagcc tgcagcacct gtacagcacc atgggagtcc    540

cctgcagagc tgcaactttg agagtgggta tagtgacgta actcaggttc ttcaagggat    600

gaacactcca actttgaaac cactagcctg taggtgtgga cgaaaaggca gctgcatgtt    660

ataaaacaat attactcat                                                 679


<210>  7880
<211>  123
<212>  PRT
<213>  Homosapiens

<400>  7880

Met Asp Leu Glu Thr Glu Leu Ser Pro Ser Thr Gly Tyr Phe Phe Leu 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Lys Gln Pro Ile Thr Asn Phe Leu Gly Val 
            20                  25                  30          


Lys Leu Gln Val Glu Glu Gln Leu Asp Gln Thr Trp Lys Thr Cys Pro 
        35                  40                  45              


Gln Phe Val Tyr Ser Ile Glu Leu Cys Met Leu Gly Ala Pro Gly Leu 
    50                  55                  60                  


Ser Thr Leu Asn Arg Thr Ser Gln Pro Ala Ala Pro Val Gln His His 
65                  70                  75                  80  


Gly Ser Pro Leu Gln Ser Cys Asn Phe Glu Ser Gly Tyr Ser Asp Val 
                85                  90                  95      


Thr Gln Val Leu Gln Gly Met Asn Thr Pro Thr Leu Lys Pro Leu Ala 
            100                 105                 110         


Cys Arg Cys Gly Arg Lys Gly Ser Cys Met Leu 
        115                 120             


<210>  7881
<211>  912
<212>  DNA
<213>  Homosapiens

<400>  7881
actcgcccgc gggggaggcc gcctcctccc ggcagcccgc cccctccggg gccacccagg     60

accaagagct gttggcgaag cccgggccga agaggcgcag gaggaaggac gcggggcggc    120

gggcagggcc tcccaagccc ggctgtcctc ggcccgtgcg cggcgcccgg agtcccactc    180

ctcccgatgc tgtcccccgc gcccggaggc cgagccaatt ctctgggaag ttcccggctt    240

gggagcggag cggccggtcg gaagaacctc gggtgctggc gcgcctgaag ttgcagacca    300

gactgaaatg tgcgagacat gtgccttttt cttaggaaag gccccaggta ccagaaaggt    360

tttcagcgcg ccgacctacg gggctaagag ggctgaaata agaaccagtg actgagcgcc    420

gggaggttta aggtttatgg aagatgttca tcgcgccgta ccctactaga ggtttgggga    480

cgtgggacac agcccctgcg ttcccgccgc ggaccccgtg ataaatacac agacacacaa    540

aatcactacc gccttgaatc tggacagcta cctcaggtgg ttaatatcta acaggagcag    600

agtggagctc agaaagactc agcgtgggtg ctgggttccg gcgcgaccag cctgatacct    660

aggtcagcat ctcagccaca caagcaggcg gcagttctgt caggaattac tacatctggt    720

gattccactt ctcatagctc accgctggga gaataattcc tcaggattaa caagatctat    780

tccagaggat cctcactgct gaagcgattt tagaagacag tgtggtctgt tgacagtatg    840

gaatattctt tacccatcag atatgatctg tatgtgattg gaaggaaata aaccaactgc    900

taacaacact tc                                                        912


<210>  7882
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  7882

Met Cys Glu Thr Cys Ala Phe Phe Leu Gly Lys Ala Pro Gly Thr Arg 
1               5                   10                  15      


Lys Val Phe Ser Ala Pro Thr Tyr Gly Ala Lys Arg Ala Glu Ile Arg 
            20                  25                  30          


Thr Ser Asp 
        35  


<210>  7883
<211>  2985
<212>  DNA
<213>  Homosapiens

<400>  7883
agcggggtag gctgcgcgag aggccgagag ggggcagcag gcgatggcgg cggcggtagc     60

tgcggcgggt cggttaggct ggttgttcgc cgcgctctgc ctgggcaacg ccgcggggga    120

ggccgcgccg ggcccgcgag tgctgggctt ctgcctggag gaggatggag cggcgggcgc    180

gggttgggta cgcggagggg cggcgcggga cacgccggac gccaccttcc tcctgcgcct    240

cttcggcccg ggcttcgcca acagctcttg gtcctgggtg gccccggagg gggcgggctg    300

ccgggaggag gcggcctccc ccgcgggcga gtggcgcgcg ctgctgcgct tgcgcctgcg    360

ggccgaggcc gtgcgcccgc actcggcgct gctggcggtg cgcgtggagc cgggtggcgg    420

ggcggctgag gaggcggcgc cgccctgggc tctgggcctg ggggcggccg ggctgctggc    480

gctggcagcg ctggcgcgag gcctgcagct gagcgcgctg gcgctggcgc ctgccgaggt    540

gcaggtgctg cgcgagagcg gctcggaggc ggagcgtgcg gcggcgcggc gtttggagcc    600

cgcgcggcgc tgggccggct gcgccttggg cgcgctgctg ctgctggcca gcctggcgca    660

ggcggcgctg gcggtgctgc tgtaccgcgc ggccggccag cgtgcggtgc ccgccgtgtt    720

gggcagcgcg gggctcgtgt tcctggtggg agaggtggtg ccggccgccg tgagcgggcg    780

ctggacgctg gcgctggcgc cgcgagcgct cggcctcagc cgcctggccg tcctgctcac    840

tctgcccgtc gcgctgcccg tggggcagct gctggagctg gcggcgcggc ccgggcggct    900

gcgggagcgg gtgctggagc tggcgcgcgg cggcggcgac ccctacagcg atctcagcaa    960

gggcgtgctg cgctgccgga ccgtggagga cgtgctcacg cccctcgaag actgcttcat   1020

gctggacgcc agcaccgtgc tggacttcgg cgtcctggcc agcatcatgc agagcggcca   1080

cacgcgcatc ccggtgtacg aggaggagcg ctccaacatc gtggacatgc tctacctcaa   1140

ggacttggcc ttcgtggatc ccgaagactg cacgccgctc agcaccatca ctcgtttcta   1200

caaccatccg ctccacttcg tcttcaacga caccaagctg gacgctgtcc tggaggaatt   1260

caagcgagga gacaccgtgg tgaagaggaa gcctgcttct ctgatggccc ctctgaagcg   1320

gaaggaggag ttctccttgt tcaaggtgtc tgatgatgaa tataaagtaa caatctcgcc   1380

tcagctgctc ttggccaccc agcgcttcct gtcccgagaa gtggatgtat tcagcccgct   1440

gcgcatctct gagaaggtcc tgctgcacct gttgaagcat cccagtgtca accaggaagt   1500

gaggtttgac gagagcaacc ggctggccac acaccactac ctgtaccagc gcagccagcc   1560

ggtggattac ttcattctca tcctgcaggg cagggttgaa gtggagatcg ggaaagaggg   1620

tctgaagttt gagaatgggg ccttcacgta ctatggagtg tcggccctaa ctgtgccatc   1680

ctcggttcac cagtccccgg tgtcctcgct ccagcccatc cgccatgacc tgcagcccga   1740

cccaggtgac ggcacgcatt catctgcgta ttgtcccgac tacaccgtga gggcgctctc   1800

tgatctgcag ctcatcaagg ttacgcgact gcagtacctc aatgcactcc tggctacccg   1860

agcccagaac ctgccacagt cccctgagaa caccgacctg caggttattc caggcagcca   1920

gaccaggctc cttggtgaga agaccaccac agcggcaggg tccagccaca gcaggcccgg   1980

cgtcccggtg gaaggcagcc ctgggcggaa cccaggcgtt taacggctca ctaggcagcc   2040

ccagatctgg ggaacagatg agcacgtggg gagctggagt gagctgagca gaagttttgt   2100

gcccgcctgc ccccatcccc tccaggccac gttttagatg gcccttgtag ttgcgggtcc   2160

tgggtgtcct cagaactaga catcaatgcc tggatccttc agccggccct gccctccttt   2220

aggagacagg agtcaccagg gcacagccct ccaggcccgc ctcaggaagg aatgaaagga   2280

atgccatcat ctctagttcc cagggcccag ccttcccctt ctcccccggg gcagggacag   2340

tgcggcatat tcagattcag acctctttgg gctgagccac cttgtgagtg cagttactgc   2400

ctttgtgtgg ccgtgacctc tatttgtttg cttttaattt gccaacctat cgctgctggc   2460

agcacttttt gagcaagccg agagcaccca ttttggctgg gggttcagat cgatggcctt   2520

gtccatgttg tcctttctgg cttccctgat ggtgtcatgt ttcagcgcat gcgccccagc   2580

ctttcccatg tgccaaacca gaagctccac tgcccgtagg ctgtccctgt agccctgctc   2640

cctccctgga ggctgctctt ctgattctga gagctggcct agtggtgctg agggcccctt   2700

tctgcttctc tgcccacctg ctgagttgcc actcgcagtg ttgtcagttc ccgtgttctg   2760

agaagaggtc atgcctggga ggaagggatc gtcatgctgc atcgaatcct ctctccgccg   2820

tgtggccccc aggagagtag ctgcctgttg cacctgctcc acacctcccc acagcctccc   2880

tgcaggtgct gtgtggccgt gatgtgcaga gagcagtgag ggagggttca tgaaccaggt   2940

ggatcctctt taaaaaaaaa aaagtttttg ttatatctct agaac                   2985


<210>  7884
<211>  659
<212>  PRT
<213>  Homosapiens

<400>  7884

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Asp Thr Val Val Lys Arg Lys 
                405                 410                 415     


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
            420                 425                 430         


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
        435                 440                 445             


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
    450                 455                 460                 


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
465                 470                 475                 480 


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
                485                 490                 495     


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
            500                 505                 510         


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
        515                 520                 525             


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
    530                 535                 540                 


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
545                 550                 555                 560 


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
                565                 570                 575     


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
            580                 585                 590         


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
        595                 600                 605             


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
    610                 615                 620                 


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
625                 630                 635                 640 


Ser His Ser Arg Pro Gly Val Pro Val Glu Gly Ser Pro Gly Arg Asn 
                645                 650                 655     


Pro Gly Val 
            


<210>  7885
<211>  3129
<212>  DNA
<213>  Homosapiens

<400>  7885
agcggggtag gctgcgcgag aggccgagag ggggcagcag gcgatggcgg cggcggtagc     60

tgcggcgggt cggttaggct ggttgttcgc cgcgctctgc ctgggcaacg ccgcggggga    120

ggccgcgccg ggcccgcgag tgctgggctt ctgcctggag gaggatggag cggcgggcgc    180

gggttgggta cgcggagggg cggcgcggga cacgccggac gccaccttcc tcctgcgcct    240

cttcggcccg ggcttcgcca acagctcttg gtcctgggtg gccccggagg gggcgggctg    300

ccgggaggag gcggcctccc ccgcgggcga gtggcgcgcg ctgctgcgct tgcgcctgcg    360

ggccgaggcc gtgcgcccgc actcggcgct gctggcggtg cgcgtggagc cgggtggcgg    420

ggcggctgag gaggcggcgc cgccctgggc tctgggcctg ggggcggccg ggctgctggc    480

gctggcagcg ctggcgcgag gcctgcagct gagcgcgctg gcgctggcgc ctgccgaggt    540

gcaggtgctg cgcgagagcg gctcggaggc ggagcgtgcg gcggcgcggc gtttggagcc    600

cgcgcggcgc tgggccggct gcgccttggg cgcgctgctg ctgctggcca gcctggcgca    660

ggcggcgctg gcggtgctgc tgtaccgcgc ggccggccag cgtgcggtgc ccgccgtgtt    720

gggcagcgcg gggctcgtgt tcctggtggg agaggtggtg ccggccgccg tgagcgggcg    780

ctggacgctg gcgctggcgc cgcgagcgct cggcctcagc cgcctggccg tcctgctcac    840

tctgcccgtc gcgctgcccg tggggcagct gctggagctg gcggcgcggc ccgggcggct    900

gcgggagcgg gtgctggagc tggcgcgcgg cggcggcgac ccctacagcg atctcagcaa    960

gggcgtgctg cgctgccgga ccgtggagga cgtgctcacg cccctcgaag actgcttcat   1020

gctggacgcc agcaccgtgc tggacttcgg cgtcctggcc agcatcatgc agagcggcca   1080

cacgcgcatc ccggtgtacg aggaggagcg ctccaacatc gtggacatgc tctacctcaa   1140

ggacttggcc ttcgtggatc ccgaagactg cacgccgctc agcaccatca ctcgtttcta   1200

caaccatccg ctccacttcg tcttcaacga caccaagctg gacgctgtcc tggaggaatt   1260

caagcgaggg aagtcccacc tggccatcgt gcagaaggtg aacaacgagg gtgaaggcga   1320

ccccttctac gaggtcctgg gcctggtcac cctggaggac gtgatcgagg agatcatcag   1380

gtccgagatc ctggacgagt ctgaagacta ccgagacacc gtggtgaaga ggaagcctgc   1440

ttctctgatg gcccctctga agcggaagga ggagttctcc ttgttcaagg tgtctgatga   1500

tgaatataaa gtaacaatct cgcctcagct gctcttggcc acccagcgct tcctgtcccg   1560

agaagtggat gtattcagcc cgctgcgcat ctctgagaag gtcctgctgc acctgttgaa   1620

gcatcccagt gtcaaccagg aagtgaggtt tgacgagagc aaccggctgg ccacacacca   1680

ctacctgtac cagcgcagcc agccggtgga ttacttcatt ctcatcctgc agggcagggt   1740

tgaagtggag atcgggaaag agggtctgaa gtttgagaat ggggccttca cgtactatgg   1800

agtgtcggcc ctaactgtgc catcctcggt tcaccagtcc ccggtgtcct cgctccagcc   1860

catccgccat gacctgcagc ccgacccagg tgacggcacg cattcatctg cgtattgtcc   1920

cgactacacc gtgagggcgc tctctgatct gcagctcatc aaggttacgc gactgcagta   1980

cctcaatgca ctcctggcta cccgagccca gaacctgcca cagtcccctg agaacaccga   2040

cctgcaggtt attccaggca gccagaccag gctccttggt gagaagacca ccacagcggc   2100

agggtccagc cacagcaggc ccggcgtccc ggtggaaggc agccctgggc ggaacccagg   2160

cgtttaacgg ctcactaggc agccccagat ctggggaaca gatgagcacg tggggagctg   2220

gagtgagctg agcagaagtt ttgtgcccgc ctgcccccat cccctccagg ccacgtttta   2280

gatggccctt gtagttgcgg gtcctgggtg tcctcagaac tagacatcaa tgcctggatc   2340

cttcagccgg ccctgccctc ctttaggaga caggagtcac cagggcacag ccctccaggc   2400

ccgcctcagg aaggaatgaa aggaatgcca tcatctctag ttcccagggc ccagccttcc   2460

ccttctcccc cggggcaggg acagtgcggc atattcagat tcagacctct ttgggctgag   2520

ccaccttgtg agtgcagtta ctgcctttgt gtggccgtga cctctatttg tttgctttta   2580

atttgccaac ctatcgctgc tggcagcact ttttgagcaa gccgagagca cccattttgg   2640

ctgggggttc agatcgatgg ccttgtccat gttgtccttt ctggcttccc tgatggtgtc   2700

atgtttcagc gcatgcgccc cagcctttcc catgtgccaa accagaagct ccactgcccg   2760

taggctgtcc ctgtagccct gctccctccc tggaggctgc tcttctgatt ctgagagctg   2820

gcctagtggt gctgagggcc cctttctgct tctctgccca cctgctgagt tgccactcgc   2880

agtgttgtca gttcccgtgt tctgagaaga ggtcatgcct gggaggaagg gatcgtcatg   2940

ctgcatcgaa tcctctctcc gccgtgtggc ccccaggaga gtagctgcct gttgcacctg   3000

ctccacacct ccccacagcc tccctgcagg tgctgtgtgg ccgtgatgtg cagagagcag   3060

tgagggaggg ttcatgaacc aggtggatcc tctttaaaaa aaaaaaagtt tttgttatat   3120

ctctagaac                                                           3129


<210>  7886
<211>  707
<212>  PRT
<213>  Homosapiens

<400>  7886

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Lys Ser His Leu Ala Ile Val 
                405                 410                 415     


Gln Lys Val Asn Asn Glu Gly Glu Gly Asp Pro Phe Tyr Glu Val Leu 
            420                 425                 430         


Gly Leu Val Thr Leu Glu Asp Val Ile Glu Glu Ile Ile Arg Ser Glu 
        435                 440                 445             


Ile Leu Asp Glu Ser Glu Asp Tyr Arg Asp Thr Val Val Lys Arg Lys 
    450                 455                 460                 


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
465                 470                 475                 480 


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
                485                 490                 495     


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
            500                 505                 510         


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
        515                 520                 525             


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
    530                 535                 540                 


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
545                 550                 555                 560 


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
                565                 570                 575     


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
            580                 585                 590         


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
        595                 600                 605             


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
    610                 615                 620                 


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
625                 630                 635                 640 


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
                645                 650                 655     


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
            660                 665                 670         


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
        675                 680                 685             


Ser His Ser Arg Pro Gly Val Pro Val Glu Gly Ser Pro Gly Arg Asn 
    690                 695                 700                 


Pro Gly Val 
705         


<210>  7887
<211>  3316
<212>  DNA
<213>  Homosapiens

<400>  7887
agcggggtag gctgcgcgag aggccgagag ggggcagcag gcgatggcgg cggcggtagc     60

tgcggcgggt cggttaggct ggttgttcgc cgcgctctgc ctgggcaacg ccgcggggga    120

ggccgcgccg ggcccgcgag tgctgggctt ctgcctggag gaggatggag cggcgggcgc    180

gggttgggta cgcggagggg cggcgcggga cacgccggac gccaccttcc tcctgcgcct    240

cttcggcccg ggcttcgcca acagctcttg gtcctgggtg gccccggagg gggcgggctg    300

ccgggaggag gcggcctccc ccgcgggcga gtggcgcgcg ctgctgcgct tgcgcctgcg    360

ggccgaggcc gtgcgcccgc actcggcgct gctggcggtg cgcgtggagc cgggtggcgg    420

ggcggctgag gaggcggcgc cgccctgggc tctgggcctg ggggcggccg ggctgctggc    480

gctggcagcg ctggcgcgag gcctgcagct gagcgcgctg gcgctggcgc ctgccgaggt    540

gcaggtgctg cgcgagagcg gctcggaggc ggagcgtgcg gcggcgcggc gtttggagcc    600

cgcgcggcgc tgggccggct gcgccttggg cgcgctgctg ctgctggcca gcctggcgca    660

ggcggcgctg gcggtgctgc tgtaccgcgc ggccggccag cgtgcggtgc ccgccgtgtt    720

gggcagcgcg gggctcgtgt tcctggtggg agaggtggtg ccggccgccg tgagcgggcg    780

ctggacgctg gcgctggcgc cgcgagcgct cggcctcagc cgcctggccg tcctgctcac    840

tctgcccgtc gcgctgcccg tggggcagct gctggagctg gcggcgcggc ccgggcggct    900

gcgggagcgg gtgctggagc tggcgcgcgg cggcggcgac ccctacagcg atctcagcaa    960

gggcgtgctg cgctgccgga ccgtggagga cgtgctcacg cccctcgaag actgcttcat   1020

gctggacgcc agcaccgtgc tggacttcgg cgtcctggcc agcatcatgc agagcggcca   1080

cacgcgcatc ccggtgtacg aggaggagcg ctccaacatc gtggacatgc tctacctcaa   1140

ggacttggcc ttcgtggatc ccgaagactg cacgccgctc agcaccatca ctcgtttcta   1200

caaccatccg ctccacttcg tcttcaacga caccaagctg gacgctgtcc tggaggaatt   1260

caagcgagga gacaccgtgg tgaagaggaa gcctgcttct ctgatggccc ctctgaagcg   1320

gaaggaggag ttctccttgt tcaaggtgtc tgatgatgaa tataaagtaa caatctcgcc   1380

tcagctgctc ttggccaccc agcgcttcct gtcccgagaa gtggatgtat tcagcccgct   1440

gcgcatctct gagaaggtcc tgctgcacct gttgaagcat cccagtgtca accaggaagt   1500

gaggtttgac gagagcaacc ggctggccac acaccactac ctgtaccagc gcagccagcc   1560

ggtggattac ttcattctca tcctgcaggg cagggttgaa gtggagatcg ggaaagaggg   1620

tctgaagttt gagaatgggg ccttcacgta ctatggagtg tcggccctaa ctgtgccatc   1680

ctcggttcac cagtccccgg tgtcctcgct ccagcccatc cgccatgacc tgcagcccga   1740

cccaggtgac ggcacgcatt catctgcgta ttgtcccgac tacaccgtga gggcgctctc   1800

tgatctgcag ctcatcaagg ttacgcgact gcagtacctc aatgcactcc tggctacccg   1860

agcccagaac ctgccacagt cccctgagaa caccgacctg caggttattc caggcagcca   1920

gaccaggctc cttggtgaga agaccaccac agcggcaggg tccagccaca gcaggcccgg   1980

cgtcccggtg gaaggcagcc ctgggcggaa cccaggcgtt taacggctca ctaggcagcc   2040

ccagatctgg ggaacagatg agcacgtggg gagctggagt gagctgagca gaagttttgt   2100

gcccgcctgc ccccatcccc tccaggccac gttttagatg gcccttgtag ttgcgggtcc   2160

tgggtgtcct cagaactaga catcaatgcc tggatccttc agccggccct gccctccttt   2220

aggagacagg agtcaccagg gcacagccct ccaggcccgc ctcaggaagg aatgaaagga   2280

atgccatcat ctctagttcc cagggcccag ccttcccctt ctcccccggg gcagggacag   2340

tgcggcatat tcagattcag acctctttgg gctgagccac cttgtgagtg cagttactgc   2400

ctttgtgtgg ccgtgacctc tatttgtttg cttttaattt gccaacctat cgctgctggc   2460

agcacttttt gagcaagccg agagcaccca ttttggctgg gggttcagat cgatggcctt   2520

gtccatgttg tcctttctgg cttccctgat ggtgtcatgt ttcagcgcat gcgccccagc   2580

ctttcccatg tgccaaacca gaagctccac tgcccgtagg ctgtccctgt agccctgctc   2640

cctccctgga ggctgctctt ctgattctga gagctggcct agtggtgctg agggcccctt   2700

tctgcttctc tgcccacctg ctgagttgcc actcgcagtg ttgtcagttc ccgtgttctg   2760

agaagaggtc atgcctggga ggaagggatc gtcatgctgc atcgaatcct ctctccgccg   2820

tgtggccccc aggagagtag ctgcctgttg cacctgctcc acacctcccc acagcctccc   2880

tgcaggtgct gtgtggccgt gatgtgcaga gagcagtgag ggagggttca tgaaccaggt   2940

ggatcctctt taaaaaaaaa aaagtttttg ttatatctct agaacatttc aagtcttttc   3000

ctttttttct gttcctagct atggggtttt agagaagtgg gaacaggaag gcatttgtct   3060

ttttcttcta gtttactaca ttttccttcc gtagttcttc agctgtgtgg aaacgggcat   3120

cacaaggaca taggatcata gattgggtag ggagggagga ggatttctgg aacttttctc   3180

aaaggaattt ggacccttat aaatgggact gaaggtcaaa acaacagtga tatccttgct   3240

tagaaattgt cctcaaggaa taaactctga gagcaagccc gggttggaaa cagatgcttt   3300

aaaatcctct ctccag                                                   3316


<210>  7888
<211>  659
<212>  PRT
<213>  Homosapiens

<400>  7888

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Asp Thr Val Val Lys Arg Lys 
                405                 410                 415     


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
            420                 425                 430         


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
        435                 440                 445             


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
    450                 455                 460                 


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
465                 470                 475                 480 


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
                485                 490                 495     


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
            500                 505                 510         


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
        515                 520                 525             


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
    530                 535                 540                 


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
545                 550                 555                 560 


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
                565                 570                 575     


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
            580                 585                 590         


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
        595                 600                 605             


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
    610                 615                 620                 


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
625                 630                 635                 640 


Ser His Ser Arg Pro Gly Val Pro Val Glu Gly Ser Pro Gly Arg Asn 
                645                 650                 655     


Pro Gly Val 
            


<210>  7889
<211>  3460
<212>  DNA
<213>  Homosapiens

<400>  7889
agcggggtag gctgcgcgag aggccgagag ggggcagcag gcgatggcgg cggcggtagc     60

tgcggcgggt cggttaggct ggttgttcgc cgcgctctgc ctgggcaacg ccgcggggga    120

ggccgcgccg ggcccgcgag tgctgggctt ctgcctggag gaggatggag cggcgggcgc    180

gggttgggta cgcggagggg cggcgcggga cacgccggac gccaccttcc tcctgcgcct    240

cttcggcccg ggcttcgcca acagctcttg gtcctgggtg gccccggagg gggcgggctg    300

ccgggaggag gcggcctccc ccgcgggcga gtggcgcgcg ctgctgcgct tgcgcctgcg    360

ggccgaggcc gtgcgcccgc actcggcgct gctggcggtg cgcgtggagc cgggtggcgg    420

ggcggctgag gaggcggcgc cgccctgggc tctgggcctg ggggcggccg ggctgctggc    480

gctggcagcg ctggcgcgag gcctgcagct gagcgcgctg gcgctggcgc ctgccgaggt    540

gcaggtgctg cgcgagagcg gctcggaggc ggagcgtgcg gcggcgcggc gtttggagcc    600

cgcgcggcgc tgggccggct gcgccttggg cgcgctgctg ctgctggcca gcctggcgca    660

ggcggcgctg gcggtgctgc tgtaccgcgc ggccggccag cgtgcggtgc ccgccgtgtt    720

gggcagcgcg gggctcgtgt tcctggtggg agaggtggtg ccggccgccg tgagcgggcg    780

ctggacgctg gcgctggcgc cgcgagcgct cggcctcagc cgcctggccg tcctgctcac    840

tctgcccgtc gcgctgcccg tggggcagct gctggagctg gcggcgcggc ccgggcggct    900

gcgggagcgg gtgctggagc tggcgcgcgg cggcggcgac ccctacagcg atctcagcaa    960

gggcgtgctg cgctgccgga ccgtggagga cgtgctcacg cccctcgaag actgcttcat   1020

gctggacgcc agcaccgtgc tggacttcgg cgtcctggcc agcatcatgc agagcggcca   1080

cacgcgcatc ccggtgtacg aggaggagcg ctccaacatc gtggacatgc tctacctcaa   1140

ggacttggcc ttcgtggatc ccgaagactg cacgccgctc agcaccatca ctcgtttcta   1200

caaccatccg ctccacttcg tcttcaacga caccaagctg gacgctgtcc tggaggaatt   1260

caagcgaggg aagtcccacc tggccatcgt gcagaaggtg aacaacgagg gtgaaggcga   1320

ccccttctac gaggtcctgg gcctggtcac cctggaggac gtgatcgagg agatcatcag   1380

gtccgagatc ctggacgagt ctgaagacta ccgagacacc gtggtgaaga ggaagcctgc   1440

ttctctgatg gcccctctga agcggaagga ggagttctcc ttgttcaagg tgtctgatga   1500

tgaatataaa gtaacaatct cgcctcagct gctcttggcc acccagcgct tcctgtcccg   1560

agaagtggat gtattcagcc cgctgcgcat ctctgagaag gtcctgctgc acctgttgaa   1620

gcatcccagt gtcaaccagg aagtgaggtt tgacgagagc aaccggctgg ccacacacca   1680

ctacctgtac cagcgcagcc agccggtgga ttacttcatt ctcatcctgc agggcagggt   1740

tgaagtggag atcgggaaag agggtctgaa gtttgagaat ggggccttca cgtactatgg   1800

agtgtcggcc ctaactgtgc catcctcggt tcaccagtcc ccggtgtcct cgctccagcc   1860

catccgccat gacctgcagc ccgacccagg tgacggcacg cattcatctg cgtattgtcc   1920

cgactacacc gtgagggcgc tctctgatct gcagctcatc aaggttacgc gactgcagta   1980

cctcaatgca ctcctggcta cccgagccca gaacctgcca cagtcccctg agaacaccga   2040

cctgcaggtt attccaggca gccagaccag gctccttggt gagaagacca ccacagcggc   2100

agggtccagc cacagcaggc ccggcgtccc ggtggaaggc agccctgggc ggaacccagg   2160

cgtttaacgg ctcactaggc agccccagat ctggggaaca gatgagcacg tggggagctg   2220

gagtgagctg agcagaagtt ttgtgcccgc ctgcccccat cccctccagg ccacgtttta   2280

gatggccctt gtagttgcgg gtcctgggtg tcctcagaac tagacatcaa tgcctggatc   2340

cttcagccgg ccctgccctc ctttaggaga caggagtcac cagggcacag ccctccaggc   2400

ccgcctcagg aaggaatgaa aggaatgcca tcatctctag ttcccagggc ccagccttcc   2460

ccttctcccc cggggcaggg acagtgcggc atattcagat tcagacctct ttgggctgag   2520

ccaccttgtg agtgcagtta ctgcctttgt gtggccgtga cctctatttg tttgctttta   2580

atttgccaac ctatcgctgc tggcagcact ttttgagcaa gccgagagca cccattttgg   2640

ctgggggttc agatcgatgg ccttgtccat gttgtccttt ctggcttccc tgatggtgtc   2700

atgtttcagc gcatgcgccc cagcctttcc catgtgccaa accagaagct ccactgcccg   2760

taggctgtcc ctgtagccct gctccctccc tggaggctgc tcttctgatt ctgagagctg   2820

gcctagtggt gctgagggcc cctttctgct tctctgccca cctgctgagt tgccactcgc   2880

agtgttgtca gttcccgtgt tctgagaaga ggtcatgcct gggaggaagg gatcgtcatg   2940

ctgcatcgaa tcctctctcc gccgtgtggc ccccaggaga gtagctgcct gttgcacctg   3000

ctccacacct ccccacagcc tccctgcagg tgctgtgtgg ccgtgatgtg cagagagcag   3060

tgagggaggg ttcatgaacc aggtggatcc tctttaaaaa aaaaaaagtt tttgttatat   3120

ctctagaaca tttcaagtct tttccttttt ttctgttcct agctatgggg ttttagagaa   3180

gtgggaacag gaaggcattt gtctttttct tctagtttac tacattttcc ttccgtagtt   3240

cttcagctgt gtggaaacgg gcatcacaag gacataggat catagattgg gtagggaggg   3300

aggaggattt ctggaacttt tctcaaagga atttggaccc ttataaatgg gactgaaggt   3360

caaaacaaca gtgatatcct tgcttagaaa ttgtcctcaa ggaataaact ctgagagcaa   3420

gcccgggttg gaaacagatg ctttaaaatc ctctctccag                         3460


<210>  7890
<211>  707
<212>  PRT
<213>  Homosapiens

<400>  7890

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Lys Ser His Leu Ala Ile Val 
                405                 410                 415     


Gln Lys Val Asn Asn Glu Gly Glu Gly Asp Pro Phe Tyr Glu Val Leu 
            420                 425                 430         


Gly Leu Val Thr Leu Glu Asp Val Ile Glu Glu Ile Ile Arg Ser Glu 
        435                 440                 445             


Ile Leu Asp Glu Ser Glu Asp Tyr Arg Asp Thr Val Val Lys Arg Lys 
    450                 455                 460                 


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
465                 470                 475                 480 


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
                485                 490                 495     


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
            500                 505                 510         


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
        515                 520                 525             


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
    530                 535                 540                 


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
545                 550                 555                 560 


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
                565                 570                 575     


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
            580                 585                 590         


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
        595                 600                 605             


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
    610                 615                 620                 


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
625                 630                 635                 640 


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
                645                 650                 655     


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
            660                 665                 670         


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
        675                 680                 685             


Ser His Ser Arg Pro Gly Val Pro Val Glu Gly Ser Pro Gly Arg Asn 
    690                 695                 700                 


Pro Gly Val 
705         


<210>  7891
<211>  4100
<212>  DNA
<213>  Homosapiens

<400>  7891
agcggggtag gctgcgcgag aggccgagag ggggcagcag gcgatggcgg cggcggtagc     60

tgcggcgggt cggttaggct ggttgttcgc cgcgctctgc ctgggcaacg ccgcggggga    120

ggccgcgccg ggcccgcgag tgctgggctt ctgcctggag gaggatggag cggcgggcgc    180

gggttgggta cgcggagggg cggcgcggga cacgccggac gccaccttcc tcctgcgcct    240

cttcggcccg ggcttcgcca acagctcttg gtcctgggtg gccccggagg gggcgggctg    300

ccgggaggag gcggcctccc ccgcgggcga gtggcgcgcg ctgctgcgct tgcgcctgcg    360

ggccgaggcc gtgcgcccgc actcggcgct gctggcggtg cgcgtggagc cgggtggcgg    420

ggcggctgag gaggcggcgc cgccctgggc tctgggcctg ggggcggccg ggctgctggc    480

gctggcagcg ctggcgcgag gcctgcagct gagcgcgctg gcgctggcgc ctgccgaggt    540

gcaggtgctg cgcgagagcg gctcggaggc ggagcgtgcg gcggcgcggc gtttggagcc    600

cgcgcggcgc tgggccggct gcgccttggg cgcgctgctg ctgctggcca gcctggcgca    660

ggcggcgctg gcggtgctgc tgtaccgcgc ggccggccag cgtgcggtgc ccgccgtgtt    720

gggcagcgcg gggctcgtgt tcctggtggg agaggtggtg ccggccgccg tgagcgggcg    780

ctggacgctg gcgctggcgc cgcgagcgct cggcctcagc cgcctggccg tcctgctcac    840

tctgcccgtc gcgctgcccg tggggcagct gctggagctg gcggcgcggc ccgggcggct    900

gcgggagcgg gtgctggagc tggcgcgcgg cggcggcgac ccctacagcg atctcagcaa    960

gggcgtgctg cgctgccgga ccgtggagga cgtgctcacg cccctcgaag actgcttcat   1020

gctggacgcc agcaccgtgc tggacttcgg cgtcctggcc agcatcatgc agagcggcca   1080

cacgcgcatc ccggtgtacg aggaggagcg ctccaacatc gtggacatgc tctacctcaa   1140

ggacttggcc ttcgtggatc ccgaagactg cacgccgctc agcaccatca ctcgtttcta   1200

caaccatccg ctccacttcg tcttcaacga caccaagctg gacgctgtcc tggaggaatt   1260

caagcgaggg aagtcccacc tggccatcgt gcagaaggtg aacaacgagg gtgaaggcga   1320

ccccttctac gaggtcctgg gcctggtcac cctggaggac gtgatcgagg agatcatcag   1380

gtccgagatc ctggacgagt ctgaagacta ccgagacacc gtggtgaaga ggaagcctgc   1440

ttctctgatg gcccctctga agcggaagga ggagttctcc ttgttcaagg tgtctgatga   1500

tgaatataaa gtaacaatct cgcctcagct gctcttggcc acccagcgct tcctgtcccg   1560

agaagtggat gtattcagcc cgctgcgcat ctctgagaag gtcctgctgc acctgttgaa   1620

gcatcccagt gtcaaccagg aagtgaggtt tgacgagagc aaccggctgg ccacacacca   1680

ctacctgtac cagcgcagcc agccggtgga ttacttcatt ctcatcctgc agggcagggt   1740

tgaagtggag atcgggaaag agggtctgaa gtttgagaat ggggccttca cgtactatgg   1800

agtgtcggcc ctaactgtgc catcctcggt tcaccagtcc ccggtgtcct cgctccagcc   1860

catccgccat gacctgcagc ccgacccagg tgacggcacg cattcatctg cgtattgtcc   1920

cgactacacc gtgagggcgc tctctgatct gcagctcatc aaggttacgc gactgcagta   1980

cctcaatgca ctcctggcta cccgagccca gaacctgcca cagtcccctg agaacaccga   2040

cctgcaggtt attccaggca gccagaccag gctccttggt gagaagacca ccacagcggc   2100

agggtccagc cacagcaggc ccggcgtccc ggtggaaggc agccctgggc ggaacccagg   2160

cgtttaacgg ctcactaggc agccccagat ctggggaaca gatgagcacg tggggagctg   2220

gagtgagctg agcagaagtt ttgtgcccgc ctgcccccat cccctccagg ccacgtttta   2280

gatggccctt gtagttgcgg gtcctgggtg tcctcagaac tagacatcaa tgcctggatc   2340

cttcagccgg ccctgccctc ctttaggaga caggagtcac cagggcacag ccctccaggc   2400

ccgcctcagg aaggaatgaa aggaatgcca tcatctctag ttcccagggc ccagccttcc   2460

ccttctcccc cggggcaggg acagtgcggc atattcagat tcagacctct ttgggctgag   2520

ccaccttgtg agtgcagtta ctgcctttgt gtggccgtga cctctatttg tttgctttta   2580

atttgccaac ctatcgctgc tggcagcact ttttgagcaa gccgagagca cccattttgg   2640

ctgggggttc agatcgatgg ccttgtccat gttgtccttt ctggcttccc tgatggtgtc   2700

atgtttcagc gcatgcgccc cagcctttcc catgtgccaa accagaagct ccactgcccg   2760

taggctgtcc ctgtagccct gctccctccc tggaggctgc tcttctgatt ctgagagctg   2820

gcctagtggt gctgagggcc cctttctgct tctctgccca cctgctgagt tgccactcgc   2880

agtgttgtca gttcccgtgt tctgagaaga ggtcatgcct gggaggaagg gatcgtcatg   2940

ctgcatcgaa tcctctctcc gccgtgtggc ccccaggaga gtagctgcct gttgcacctg   3000

ctccacacct ccccacagcc tccctgcagg tgctgtgtgg ccgtgatgtg cagagagcag   3060

tgagggaggg ttcatgaacc aggtggatcc tctttaaaaa aaaaaaagtt tttgttatat   3120

ctctagaaca tttcaagtct tttccttttt ttctgttcct agctatgggg ttttagagaa   3180

gtgggaacag gaaggcattt gtctttttct tctagtttac tacattttcc ttccgtagtt   3240

cttcagctgt gtggaaacgg gcatcacaag gacataggat catagattgg gtagggaggg   3300

aggaggattt ctggaacttt tctcaaagga atttggaccc ttataaatgg gactgaaggt   3360

caaaacaaca gtgatatcct tgcttagaaa ttgtcctcaa ggaataaact ctgagagcaa   3420

gcccgggttg gaaacagatg ctttaaaatc ctctctccag aacagtggtt ttttgtttgt   3480

ttatttgaga tggagtctca ctctgtcacc caggctggag tgcagtggtg agatcttggc   3540

tcactgcaac ctccacctcc caggttcaag ccattctcct gtctcagccc cctgagtagc   3600

tgggattaca ggtgcccacc accacacccg gctaattttt gtatttttag tagagatggg   3660

gtttcaccat gttggccagg ctgatcttga actcctgacc tcaggtgatc tgcctgcctt   3720

ggcctcccaa agtgctggga ttataggtgt gagctaagat cagggattct taaccttggc   3780

tgcacaccag aatcacctgg caaattaaaa atacgtggac ctgccaccag agcttgtgat   3840

ttaatcagag tcggcatcag agttttcaat tttttattta tttattatta ttattattat   3900

tattattatt attgagacaa gatcttgctc tgtcgcccag actggagtgc agtggtgtga   3960

tcacggcttg ctgcagcctc gacctccctg gttcaggcca tcctgccacc tcagcctcct   4020

gagtagtagg gactacaggt aggcaccacc acacccagct aatactttta attttttttt   4080

gtagagatag ggtctcatta                                               4100


<210>  7892
<211>  707
<212>  PRT
<213>  Homosapiens

<400>  7892

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Lys Ser His Leu Ala Ile Val 
                405                 410                 415     


Gln Lys Val Asn Asn Glu Gly Glu Gly Asp Pro Phe Tyr Glu Val Leu 
            420                 425                 430         


Gly Leu Val Thr Leu Glu Asp Val Ile Glu Glu Ile Ile Arg Ser Glu 
        435                 440                 445             


Ile Leu Asp Glu Ser Glu Asp Tyr Arg Asp Thr Val Val Lys Arg Lys 
    450                 455                 460                 


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
465                 470                 475                 480 


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
                485                 490                 495     


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
            500                 505                 510         


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
        515                 520                 525             


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
    530                 535                 540                 


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
545                 550                 555                 560 


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
                565                 570                 575     


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
            580                 585                 590         


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
        595                 600                 605             


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
    610                 615                 620                 


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
625                 630                 635                 640 


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
                645                 650                 655     


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
            660                 665                 670         


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
        675                 680                 685             


Ser His Ser Arg Pro Gly Val Pro Val Glu Gly Ser Pro Gly Arg Asn 
    690                 695                 700                 


Pro Gly Val 
705         


<210>  7893
<211>  4243
<212>  DNA
<213>  Homosapiens

<400>  7893
ggccgagagg gggcagcagg cgatggcggc ggcggtagct gcggcgggtc ggttaggctg     60

gttgttcgcc gcgctctgcc tgggcaacgc cgcgggggag gccgcgccgg gcccgcgagt    120

gctgggcttc tgcctggagg aggatggagc ggcgggcgcg ggttgggtac gcggaggggc    180

ggcgcgggac acgccggacg ccaccttcct cctgcgcctc ttcggcccgg gcttcgccaa    240

cagctcttgg tcctgggtgg ccccggaggg ggcgggctgc cgggaggagg cggcctcccc    300

cgcgggcgag tggcgcgcgc tgctgcgctt gcgcctgcgg gccgaggccg tgcgcccgca    360

ctcggcgctg ctggcggtgc gcgtggagcc gggtggcggg gcggctgagg aggcggcgcc    420

gccctgggct ctgggcctgg gggcggccgg gctgctggcg ctggcagcgc tggcgcgagg    480

cctgcagctg agcgcgctgg cgctggcgcc tgccgaggtg caggtgctgc gcgagagcgg    540

ctcggaggcg gagcgtgcgg cggcgcggcg tttggagccc gcgcggcgct gggccggctg    600

cgccttgggc gcgctgctgc tgctggccag cctggcgcag gcggcgctgg cggtgctgct    660

gtaccgcgcg gccggccagc gtgcggtgcc cgccgtgttg ggcagcgcgg ggctcgtgtt    720

cctggtggga gaggtggtgc cggccgccgt gagcgggcgc tggacgctgg cgctggcgcc    780

gcgagcgctc ggcctcagcc gcctggccgt cctgctcact ctgcccgtcg cgctgcccgt    840

ggggcagctg ctggagctgg cggcgcggcc cgggcggctg cgggagcggg tgctggagct    900

ggcgcgcggc ggcggcgacc cctacagcga tctcagcaag ggcgtgctgc gctgccggac    960

cgtggaggac gtgctcacgc ccctcgaaga ctgcttcatg ctggacgcca gcaccgtgct   1020

ggacttcggc gtcctggcca gcatcatgca gagcggccac acgcgcatcc cggtgtacga   1080

ggaggagcgc tccaacatcg tggacatgct ctacctcaag gacttggcct tcgtggatcc   1140

cgaagactgc acgccgctca gcaccatcac tcgtttctac aaccatccgc tccacttcgt   1200

cttcaacgac accaagctgg acgctgtcct ggaggaattc aagcgaggag acaccgtggt   1260

gaagaggaag cctgcttctc tgatggcccc tctgaagcgg aaggaggagt tctccttgtt   1320

caaggtgtct gatgatgaat ataaagtaac aatctcgcct cagctgctct tggccaccca   1380

gcgcttcctg tcccgagaag tggatgtatt cagcccgctg cgcatctctg agaaggtcct   1440

gctgcacctg ttgaagcatc ccagtgtcaa ccaggaagtg aggtttgacg agagcaaccg   1500

gctggccaca caccactacc tgtaccagcg cagccagccg gtggattact tcattctcat   1560

cctgcagggc agggttgaag tggagatcgg gaaagagggt ctgaagtttg agaatggggc   1620

cttcacgtac tatggagtgt cggccctaac tgtgccatcc tcggttcacc agtccccggt   1680

gtcctcgctc cagcccatcc gccatgacct gcagcccgac ccaggtgacg gcacgcattc   1740

atctgcgtat tgtcccgact acaccgtgag ggcgctctct gatctgcagc tcatcaaggt   1800

tacgcgactg cagtacctca atgcactcct ggctacccga gcccagaacc tgccacagtc   1860

ccctgagaac accgacctgc aggttattcc aggcagccag accaggctcc ttggtgagaa   1920

gaccaccaca gcggcagggt ccagccacag caggcccagc cttccccttc tcccccgggg   1980

cagggacagt gcggcatatt cagattcaga cctctttggg ctgagccacc ttgtgagtgc   2040

agttactgcc tttgtgtggc cgtgacctct atttgtttgc ttttaatttg ccaacctatc   2100

gctgctggca gcactttttg agcaagccga gagcacccat tttggctggg ggttcagatc   2160

gatggccttg tccatgttgt cctttctggc ttccctgatg gtgtcatgtt tcagcgcatg   2220

cgccccagcc tttcccatgt gccaaaccag aagctccact gcccgtaggc tgtccctgta   2280

gccctgctcc ctccctggag gctgctcttc tgattctgag agctggccta gtggtgctga   2340

gggccccttt ctgcttctct gcccacctgc tgagttgcca ctcgcagtgt tgtcagttcc   2400

cgtgttctga gaagaggtca tgcctgggag gaagggatcg tcatgctgca tcgaatcctc   2460

tctccgccgt gtggccccca ggagagtagc tgcctgttgc acctgctcca cacctcccca   2520

cagcctccct gcaggtgctg tgtggccgtg atgtgcagag agcagtgagg gagggttcat   2580

gaaccaggtg gatcctcttt aaaaaaaaaa aagtttttgt tatatctcta gaacatttca   2640

agtcttttcc tttttttctg ttcctagcta tggggtttta gagaagtggg aacaggaagg   2700

catttgtctt tttcttctag tttactacat tttccttccg tagttcttca gctgtgtgga   2760

aacgggcatc acaaggacat aggatcatag attgggtagg gagggaggag gatttctgga   2820

acttttctca aaggaatttg gacccttata aatgggactg aaggtcaaaa caacagtgat   2880

atccttgctt agaaattgtc ctcaaggaat aaactctgag agcaagcccg ggttggaaac   2940

agatgcttta aaatcctctc tccagaacag tggttttttg tttgtttatt tgagatggag   3000

tctcactctg tcacccaggc tggagtgcag tggtgagatc ttggctcact gcaacctcca   3060

cctcccaggt tcaagccatt ctcctgtctc agccccctga gtagctggga ttacaggtgc   3120

ccaccaccac acccggctaa tttttgtatt tttagtagag atggggtttc accatgttgg   3180

ccaggctgat cttgaactcc tgacctcagg tgatctgcct gccttggcct cccaaagtgc   3240

tgggattata ggtgtgagct aagatcaggg attcttaacc ttggctgcac accagaatca   3300

cctggcaaat taaaaatacg tggacctgcc accagagctt gtgatttaat cagagtcggc   3360

atcagagttt tcaatttttt atttatttat tattattatt attattatta ttattattga   3420

gacaagatct tgctctgtcg cccagactgg agtgcagtgg tgtgatcacg gcttgctgca   3480

gcctcgacct ccctggttca ggccatcctg ccacctcagc ctcctgagta gtagggacta   3540

caggtaggca ccaccacacc cagctaatac ttttaatttt tttttgtaga gatagggtct   3600

cattatgttg cctggggtag tctcgaactc ctaggctcaa gcgatcctcc tgcctcggcc   3660

tcccaaagtg ttgagattat aggcgtgagc caccgtgccc agattcacag aagtttcata   3720

cacctttcac ccaggttccc ctaatgttaa cagcttacat ataaccttgg tacatttatc   3780

aaaactaaag gtgcaatcat actaatagct agagtttatt tggattttac catttttccc   3840

aatgtccctt ttctgctgca gcagccaatc caggatgcca tactgcactt agagctgttg   3900

ctttcttttt tcctaacttt atattttgaa ataatttcag atgataggaa gttgtaaagg   3960

taagggcccc acgcaccctt catctagttt ccctccatgg ttacatctta tatggttgta   4020

atgcagtatt ccaacaaaga ctctgacact ggtgcgatgt gggtggacag tccaaatcat   4080

ttgtcacatg tacatctgtg taactaccac tgcaatcagg ataaagaagt cccatcccca   4140

caaggatctc cctccccacc ttccctaact cctggtaacc actaatcgtt catctcttct   4200

tattttgtca tttcaagaat gttgtataaa tgggagcata gtg                     4243


<210>  7894
<211>  680
<212>  PRT
<213>  Homosapiens

<400>  7894

Met Ala Ala Ala Val Ala Ala Ala Gly Arg Leu Gly Trp Leu Phe Ala 
1               5                   10                  15      


Ala Leu Cys Leu Gly Asn Ala Ala Gly Glu Ala Ala Pro Gly Pro Arg 
            20                  25                  30          


Val Leu Gly Phe Cys Leu Glu Glu Asp Gly Ala Ala Gly Ala Gly Trp 
        35                  40                  45              


Val Arg Gly Gly Ala Ala Arg Asp Thr Pro Asp Ala Thr Phe Leu Leu 
    50                  55                  60                  


Arg Leu Phe Gly Pro Gly Phe Ala Asn Ser Ser Trp Ser Trp Val Ala 
65                  70                  75                  80  


Pro Glu Gly Ala Gly Cys Arg Glu Glu Ala Ala Ser Pro Ala Gly Glu 
                85                  90                  95      


Trp Arg Ala Leu Leu Arg Leu Arg Leu Arg Ala Glu Ala Val Arg Pro 
            100                 105                 110         


His Ser Ala Leu Leu Ala Val Arg Val Glu Pro Gly Gly Gly Ala Ala 
        115                 120                 125             


Glu Glu Ala Ala Pro Pro Trp Ala Leu Gly Leu Gly Ala Ala Gly Leu 
    130                 135                 140                 


Leu Ala Leu Ala Ala Leu Ala Arg Gly Leu Gln Leu Ser Ala Leu Ala 
145                 150                 155                 160 


Leu Ala Pro Ala Glu Val Gln Val Leu Arg Glu Ser Gly Ser Glu Ala 
                165                 170                 175     


Glu Arg Ala Ala Ala Arg Arg Leu Glu Pro Ala Arg Arg Trp Ala Gly 
            180                 185                 190         


Cys Ala Leu Gly Ala Leu Leu Leu Leu Ala Ser Leu Ala Gln Ala Ala 
        195                 200                 205             


Leu Ala Val Leu Leu Tyr Arg Ala Ala Gly Gln Arg Ala Val Pro Ala 
    210                 215                 220                 


Val Leu Gly Ser Ala Gly Leu Val Phe Leu Val Gly Glu Val Val Pro 
225                 230                 235                 240 


Ala Ala Val Ser Gly Arg Trp Thr Leu Ala Leu Ala Pro Arg Ala Leu 
                245                 250                 255     


Gly Leu Ser Arg Leu Ala Val Leu Leu Thr Leu Pro Val Ala Leu Pro 
            260                 265                 270         


Val Gly Gln Leu Leu Glu Leu Ala Ala Arg Pro Gly Arg Leu Arg Glu 
        275                 280                 285             


Arg Val Leu Glu Leu Ala Arg Gly Gly Gly Asp Pro Tyr Ser Asp Leu 
    290                 295                 300                 


Ser Lys Gly Val Leu Arg Cys Arg Thr Val Glu Asp Val Leu Thr Pro 
305                 310                 315                 320 


Leu Glu Asp Cys Phe Met Leu Asp Ala Ser Thr Val Leu Asp Phe Gly 
                325                 330                 335     


Val Leu Ala Ser Ile Met Gln Ser Gly His Thr Arg Ile Pro Val Tyr 
            340                 345                 350         


Glu Glu Glu Arg Ser Asn Ile Val Asp Met Leu Tyr Leu Lys Asp Leu 
        355                 360                 365             


Ala Phe Val Asp Pro Glu Asp Cys Thr Pro Leu Ser Thr Ile Thr Arg 
    370                 375                 380                 


Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp Thr Lys Leu Asp 
385                 390                 395                 400 


Ala Val Leu Glu Glu Phe Lys Arg Gly Asp Thr Val Val Lys Arg Lys 
                405                 410                 415     


Pro Ala Ser Leu Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu 
            420                 425                 430         


Phe Lys Val Ser Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu 
        435                 440                 445             


Leu Leu Ala Thr Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser 
    450                 455                 460                 


Pro Leu Arg Ile Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro 
465                 470                 475                 480 


Ser Val Asn Gln Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr 
                485                 490                 495     


His His Tyr Leu Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu 
            500                 505                 510         


Ile Leu Gln Gly Arg Val Glu Val Glu Ile Gly Lys Glu Gly Leu Lys 
        515                 520                 525             


Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Ser Ala Leu Thr Val 
    530                 535                 540                 


Pro Ser Ser Val His Gln Ser Pro Val Ser Ser Leu Gln Pro Ile Arg 
545                 550                 555                 560 


His Asp Leu Gln Pro Asp Pro Gly Asp Gly Thr His Ser Ser Ala Tyr 
                565                 570                 575     


Cys Pro Asp Tyr Thr Val Arg Ala Leu Ser Asp Leu Gln Leu Ile Lys 
            580                 585                 590         


Val Thr Arg Leu Gln Tyr Leu Asn Ala Leu Leu Ala Thr Arg Ala Gln 
        595                 600                 605             


Asn Leu Pro Gln Ser Pro Glu Asn Thr Asp Leu Gln Val Ile Pro Gly 
    610                 615                 620                 


Ser Gln Thr Arg Leu Leu Gly Glu Lys Thr Thr Thr Ala Ala Gly Ser 
625                 630                 635                 640 


Ser His Ser Arg Pro Ser Leu Pro Leu Leu Pro Arg Gly Arg Asp Ser 
                645                 650                 655     


Ala Ala Tyr Ser Asp Ser Asp Leu Phe Gly Leu Ser His Leu Val Ser 
            660                 665                 670         


Ala Val Thr Ala Phe Val Trp Pro 
        675                 680 


<210>  7895
<211>  1655
<212>  DNA
<213>  Homosapiens

<400>  7895
aagaggatcc acctggttca tgaaccctcc ctcactgctc tctgcacatc acggccacac     60

agcacctgca gggaggctgt ggggaggtgt ggagcaggtg caacaggcag ctactctcct    120

gggggccaca cggcggagag aggattcgat gcagcatgac gatcccttcc tcccaggcat    180

gacctcttct cagaacacgg gaactgacaa cactgcgagt ggcaactcag cagatctggg    240

gctgcctagt gagccgttaa acgcctgggt tccgcccagg gctgccttcc accgggacgc    300

cgggcctgct gtggctggac cctacaggag acaagggaag gagaattaac atcaaagctg    360

gttcaagcga ttcttctgcc tcagcctcct gagtatgtga gactacaggc acgcaccacc    420

acgcccagct aatgtttgta tttttagcag agatggagtt tcaccatatt ggccaggctg    480

gtctcgaact cccgatctcg tgatctgcct gcctgggcct cccaaagagc tgggattaca    540

ggcgtgagcc actgcgccca gccaggaaga ctttcttcat ggcaaacagt gggttctttc    600

aggggacatt tctgtaatgt acaaaagaac ctgcaaaaac aaaagcacct agggagacag    660

aagactggga aaggcccatg aagggcagag ctctctcagt aatggaggaa actaatagga    720

ctgctgctaa tggagcccca ggtgagccct gggattgcaa ggccaccgct ggcacaggca    780

accatgcttg tgtggaggtg caggcgtgag ccctcctgca agggggctct ctgccagcac    840

ccatgcaggg ctcagaaggg ggcctggctg tggatcttgc tgggttccag cagcacagag    900

gcccactggc ctctgacgca acatacgcct ggggaagtgt gcaggcccag cggagacaga    960

actgccaaga gtctggactc acggtagtct tcagactcgt ccaggatctc ggacctgatg   1020

atctcctcga tcacgtcctc cagggtgacc aggcccagga cctcgtagaa ggggtcgcct   1080

tcaccctcgt tgttcacctt ctgcacgatg gccaggtggg acttccctgt ggggggagga   1140

cactcatgga acagcttgct gggccccccc cagtttgatt catctcccct ggtataggcc   1200

caccaaaagg acacggctaa cgttcatgct cctacaacgt gccaggcaca gagccacact   1260

cttttctagg tttttactta agactcccag cgtgattatg agaactggcc ttattttcac   1320

acaggttgaa aatgaagcag tgggctcatg cccatctgca caaggccccc caggcagagc   1380

tggcagagct gggatccagc tccaggtccg tgcacctcca tgacatggat gcagtttaga   1440

caaggatgcc tccctccagt ggagaacaca aatgcctcac acatcagcca gcctgcacat   1500

gcaggctaac aagggcactg actctggaaa cacaggctct cctgcgacag tccacacggg   1560

gcagctgagt ggggccaccc agcctgactg tccttgggag gatttcctaa gtctttttct   1620

tcttaaagta aatatatatg ctgtccatcc tacat                              1655


<210>  7896
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  7896

Met Asn Pro Pro Ser Leu Leu Ser Ala His His Gly His Thr Ala Pro 
1               5                   10                  15      


Ala Gly Arg Leu Trp Gly Gly Val Glu Gln Val Gln Gln Ala Ala Thr 
            20                  25                  30          


Leu Leu Gly Ala Thr Arg Arg Arg Glu Asp Ser Met Gln His Asp Asp 
        35                  40                  45              


Pro Phe Leu Pro Gly Met Thr Ser Ser Gln Asn Thr Gly Thr Asp Asn 
    50                  55                  60                  


Thr Ala Ser Gly Asn Ser Ala Asp Leu Gly Leu Pro Ser Glu Pro Leu 
65                  70                  75                  80  


Asn Ala Trp Val Pro Pro Arg Ala Ala Phe His Arg Asp Ala Gly Pro 
                85                  90                  95      


Ala Val Ala Gly Pro Tyr Arg Arg Gln Gly Lys Glu Asn 
            100                 105                 


<210>  7897
<211>  691
<212>  DNA
<213>  Homosapiens

<400>  7897
aagaggatcc acctggttca tgaaccctcc ctcactgctc tctgcacatc acggccacac     60

agcacctgca gggaggctgt ggggaggtgt ggagcaggtg caacaggcag ctactctcct    120

gggggccaca cggcggagag aggattcgat gcagcatgac gatcccttcc tcccaggcat    180

gacctcttct cagaacacgg gaactgacaa cactgcgagt ggcaactcag cagatctggg    240

gctgcctagt gagccgttaa acgcctgggt tccgcccagg gctgccttcc accgggacgc    300

cgggcctgct gtggctggac cctacaggag acaagggaag gagaattaac atcaaagctg    360

gttgaaaatg aagcagtggg ctcatgccca tctgcacaag gccccccagg cagagctggc    420

agagctggga tccagctcca ggtccgtgca cctccatgac atggatgcag tttagacaag    480

gatgcctccc tccagtggag aacacaaatg cctcacacat cagccagcct gcacatgcag    540

gctaacaagg gcactgactc tggaaacaca ggctctcctg cgacagtcca cacggggcag    600

ctgagtgggg ccacccagcc tgactgtcct tgggaggatt tcctaagtct ttttcttctt    660

aaagtaaata tatatgctgt ccatcctaca t                                   691


<210>  7898
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  7898

Met Asn Pro Pro Ser Leu Leu Ser Ala His His Gly His Thr Ala Pro 
1               5                   10                  15      


Ala Gly Arg Leu Trp Gly Gly Val Glu Gln Val Gln Gln Ala Ala Thr 
            20                  25                  30          


Leu Leu Gly Ala Thr Arg Arg Arg Glu Asp Ser Met Gln His Asp Asp 
        35                  40                  45              


Pro Phe Leu Pro Gly Met Thr Ser Ser Gln Asn Thr Gly Thr Asp Asn 
    50                  55                  60                  


Thr Ala Ser Gly Asn Ser Ala Asp Leu Gly Leu Pro Ser Glu Pro Leu 
65                  70                  75                  80  


Asn Ala Trp Val Pro Pro Arg Ala Ala Phe His Arg Asp Ala Gly Pro 
                85                  90                  95      


Ala Val Ala Gly Pro Tyr Arg Arg Gln Gly Lys Glu Asn 
            100                 105                 


<210>  7899
<211>  370
<212>  DNA
<213>  Homosapiens

<400>  7899
gtgtccgcct gttagcatgg tggctgaggt ctgcagggct gtacagagtc tgtgcgtcat     60

ggccgggccg cctgccctgc atgcttccag aagtatcgct ttaatcatgc gtcgattttc    120

aaactagcac tttgggaggt caaagcgggc agatcatgag gtcaggagtt ccgagatcag    180

cctgaccaat atggtgaaac cccggtctct actaaaaata caaaaactag ccgggcgtcg    240

tggcacacgc ctgtaatctc agctactcag gagaatagga gaatcgcttg aacccaggag    300

gcggaggctg cagtgagccg agattgcgct actgcacgcc agcctggaca aaagagggag    360

actccatctc                                                           370


<210>  7900
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  7900

Met Val Ala Glu Val Cys Arg Ala Val Gln Ser Leu Cys Val Met Ala 
1               5                   10                  15      


Gly Pro Pro Ala Leu His Ala Ser Arg Ser Ile Ala Leu Ile Met Arg 
            20                  25                  30          


Arg Phe Ser Asn 
        35      


<210>  7901
<211>  850
<212>  DNA
<213>  Homosapiens

<400>  7901
ttttattttt ttgtaaagac acggtctctc tatgttgcct aggctggtgt tgaacttctg     60

gccttaagtg atcctcccgc ctcagcctcc taaagtgcta gggttacagg tgtgaatcac    120

tacatctggc ctaaatttaa aaaagttttt agtctacatc cagtgaccta tcagggatgc    180

ttgttatttt atacaagctg ctttgttatc atatcagcat tctcttcagc cagctccaag    240

gcagatagtc acccctctct ctgtgtggtt ggggtgggag caggccccgt ggagggagcg    300

gtgctgagga catgtccctg gcgttccgat gctgctccat cgaggacccc ctggcctcag    360

gaggaaggag caggcgatgc agccccttag tgtggtcgtg ttgactgaca ggtggctgat    420

gcctgagcgc gccctcttct tccatcttag gagacaccgt ggtgaagagg aagcctgctt    480

ctctgatggc ccctctgaag cggaaggagg agttctcctt gttcaaggtg tctgatgatg    540

aatataaagt aacaatctcg cctcagctgc tcttggccac ccagcgcttc ctgtcccgag    600

aagtggatgt attcagcccg ctgcgcatct ctgagaaggt cctgctgcac ctgttgaagc    660

atcccagtgt caaccaggaa gtgaggtttg acgagagcaa ccggctggcc acacaccact    720

acctgtacca gcgcagccag ccggtggatt acttcattct catcctgcag gtagctgtgg    780

gtcccaggcc tggagtccct cctgcttcct caggccaggg aagggtctag gagaagaggg    840

gagcaggggc                                                           850


<210>  7902
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  7902

Met Ala Pro Leu Lys Arg Lys Glu Glu Phe Ser Leu Phe Lys Val Ser 
1               5                   10                  15      


Asp Asp Glu Tyr Lys Val Thr Ile Ser Pro Gln Leu Leu Leu Ala Thr 
            20                  25                  30          


Gln Arg Phe Leu Ser Arg Glu Val Asp Val Phe Ser Pro Leu Arg Ile 
        35                  40                  45              


Ser Glu Lys Val Leu Leu His Leu Leu Lys His Pro Ser Val Asn Gln 
    50                  55                  60                  


Glu Val Arg Phe Asp Glu Ser Asn Arg Leu Ala Thr His His Tyr Leu 
65                  70                  75                  80  


Tyr Gln Arg Ser Gln Pro Val Asp Tyr Phe Ile Leu Ile Leu Gln Val 
                85                  90                  95      


Ala Val Gly Pro Arg Pro Gly Val Pro Pro Ala Ser Ser Gly Gln Gly 
            100                 105                 110         


Arg Val 
        


<210>  7903
<211>  543
<212>  DNA
<213>  Homosapiens

<400>  7903
ttctcctaga cccttccctg gcctgaggaa gcaggaggga ctccaggcct gggacccaca     60

gctacctgca ggatgagaat gaagtaatcc accggctggc tgcgctggta caggtagtgg    120

tgtgtggcca gccggttgct ctcgtcaaac ctcacttcct ggttgacact gggatgcttc    180

aacaggtgca gcaggacctt ctcagagatg cgcagcgggc tgaatacatc cacttctgca    240

cgtggtggaa aaaagggaca gtgtccactg gggcctagtg gccagtggaa ccacacccaa    300

cactgtaggc aatttaaagt tattgtgccc accagggatc tcccgggtgg cctgtgagca    360

gctgccccta acacctcaac acaagagaac taggcagggg ccaggtgcgg tggacgcctg    420

taatcccagc tacttgggag gctgaggcag gagaatcact tgaacccaga aggcggaggt    480

tgcagtgagc caacatcgtg ccactgcact ccagcctggg tgacagagcg agaccctatc    540

ttt                                                                  543


<210>  7904
<211>  49
<212>  PRT
<213>  Homosapiens

<400>  7904

Met Arg Ser Gly Leu Asn Thr Ser Thr Ser Ala Arg Gly Gly Lys Lys 
1               5                   10                  15      


Gly Gln Cys Pro Leu Gly Pro Ser Gly Gln Trp Asn His Thr Gln His 
            20                  25                  30          


Cys Arg Gln Phe Lys Val Ile Val Pro Thr Arg Asp Leu Pro Gly Gly 
        35                  40                  45              


Leu 
    


<210>  7905
<211>  1729
<212>  DNA
<213>  Homosapiens

<400>  7905
ttcagctctt ctcactgggg ggtgtgagga acagggggga ccatggactt catcagcatt     60

cagcagttgg taagtggaga aagagttgaa gggaaagtgt tgggatttgg acatggagtt    120

cctgaccctg gagcctggcc tagtgactgg aggaggggcc cccaagaggc tgtggcccgg    180

gagaagctga aattggaaga agagaagaag aagaaacttg aaagatttaa cagtaccaga    240

tttaatctgg ataacctggc tgacttggaa aacttggttc aaagacggaa aaagcgactg    300

agacacagag tcccccccag gaaacctgag cccctggtta agccgcagtc ccaggcccag    360

gtggagcctg tgggcctgga gatgttcctg aaggcagctg ctgagaacca ggagtacctg    420

attgacaagt acttgacaga cggaggggac cccaatgccc atgacaagct ccaccgcacc    480

gccttgcact gggcctgtct gaagggtcac agccagctgg tgaacaagct gctggtggca    540

ggtgccacag tggacgcgcg agacttgctg gacaggacac ctgtgttctg ggcctgccgc    600

ggaggacatc tggtcatcct caaacagctg cttaaccagg gagcccgggt caatgcccgg    660

gacaagatcg ggagcacccc cctgcacgtg gcagtgcgca cccggcaccc cgactgcctg    720

gagcacctca tcgagtgtgg cgcccacctg aacgcacagt ctgtacgttt caaattacac    780

tggtgtaggc ctgtactgct ggtggggctg ggcccctaaa cgccagaaag tgaatcttaa    840

gaagctctgc cctaaactga gaaccacatg ctgagggaag ggctgaaagg tgaaggctca    900

gcctccctca catgggtcct gggttacatt aggtaccggg ctgattgata ggcatttggc    960

catggttcct tttcgtctac ctttgggggc cttctcaggc ccagaacaag gctgttgtta   1020

ctatgtggaa aagctgacca gtgctgcaca ctaggggcac acacctttcc atgagcagct   1080

cctgccctgt ggcgacagcc agcgtgcacc cagacgctgg tgccatggcg aagcaggcgt   1140

tcaagaccat ggagaagaca actcctcatc tagaaaatga ggacacctca gtgacaaaca   1200

caccttttta taccaatcag tatcctctgt tcattaaaac tggctatcca ttacagccta   1260

gccgtctttc ctgggccgag aggagcccat gcttcagtca ccagggactg tctgataggg   1320

cccacgcctg ttagccatgc cggccgacag caagataggc cgagtgcaga gtgggcggga   1380

tgcggggtcc tggcactagg cttttgtgct taaggcacct ctgctcactg acgacaaggt   1440

caaagagcag tggttctcca cctcagctgc ttatcagaat caccaggaag gtttaaaaag   1500

tcctgatgtc cagaccctaa gtcagaagcc ctgaggggag gatccaggta ttctcatgca   1560

gaggccatgc ttgtctatgt gggaaatcct aggaatctac agaaagcaga caactaggga   1620

gtccagcaaa atctcgggtg caagataaac acacaaaaac ctgtttctac ctcctagaaa   1680

tgaacatgta gacacaaaag ttaaaaatat gtactgttta caattgctg               1729


<210>  7906
<211>  258
<212>  PRT
<213>  Homosapiens

<400>  7906

Met Asp Phe Ile Ser Ile Gln Gln Leu Val Ser Gly Glu Arg Val Glu 
1               5                   10                  15      


Gly Lys Val Leu Gly Phe Gly His Gly Val Pro Asp Pro Gly Ala Trp 
            20                  25                  30          


Pro Ser Asp Trp Arg Arg Gly Pro Gln Glu Ala Val Ala Arg Glu Lys 
        35                  40                  45              


Leu Lys Leu Glu Glu Glu Lys Lys Lys Lys Leu Glu Arg Phe Asn Ser 
    50                  55                  60                  


Thr Arg Phe Asn Leu Asp Asn Leu Ala Asp Leu Glu Asn Leu Val Gln 
65                  70                  75                  80  


Arg Arg Lys Lys Arg Leu Arg His Arg Val Pro Pro Arg Lys Pro Glu 
                85                  90                  95      


Pro Leu Val Lys Pro Gln Ser Gln Ala Gln Val Glu Pro Val Gly Leu 
            100                 105                 110         


Glu Met Phe Leu Lys Ala Ala Ala Glu Asn Gln Glu Tyr Leu Ile Asp 
        115                 120                 125             


Lys Tyr Leu Thr Asp Gly Gly Asp Pro Asn Ala His Asp Lys Leu His 
    130                 135                 140                 


Arg Thr Ala Leu His Trp Ala Cys Leu Lys Gly His Ser Gln Leu Val 
145                 150                 155                 160 


Asn Lys Leu Leu Val Ala Gly Ala Thr Val Asp Ala Arg Asp Leu Leu 
                165                 170                 175     


Asp Arg Thr Pro Val Phe Trp Ala Cys Arg Gly Gly His Leu Val Ile 
            180                 185                 190         


Leu Lys Gln Leu Leu Asn Gln Gly Ala Arg Val Asn Ala Arg Asp Lys 
        195                 200                 205             


Ile Gly Ser Thr Pro Leu His Val Ala Val Arg Thr Arg His Pro Asp 
    210                 215                 220                 


Cys Leu Glu His Leu Ile Glu Cys Gly Ala His Leu Asn Ala Gln Ser 
225                 230                 235                 240 


Val Arg Phe Lys Leu His Trp Cys Arg Pro Val Leu Leu Val Gly Leu 
                245                 250                 255     


Gly Pro 
        


<210>  7907
<211>  2945
<212>  DNA
<213>  Homosapiens

<400>  7907
ttcagctctt ctcactgggg ggtgtgagga acagggggga ccatggactt catcagcatt     60

cagcagttgg taagtggaga aagagttgaa gggaaagtgt tgggatttgg acatggagtt    120

cctgaccctg gagcctggcc tagtgactgg aggaggggcc cccaagaggc tgtggcccgg    180

gagaagctga aattggaaga agagaagaag aagaaacttg aaagatttaa cagtaccaga    240

tttaatctgg ataacctggc tgacttggaa aacttggttc aaagacggaa aaagcgactg    300

agacacagag tcccccccag gaaacctgag cccctggtta agctccaccg caccgccttg    360

cactgggcct gtctgaaggg tcacagccag ctggtgaaca agctgctggt ggcaggtgcc    420

acagtggacg cgcgagactt gctggacagg acacctgtgt tctgggcctg ccgcggagga    480

catctggtca tcctcaaaca gctgcttaac cagggagccc gggtcaatgc ccgggacaag    540

atcgggagca cccccctgca cgtggcagtg cgcacccggc accccgactg cctggagcac    600

ctcatcgagt gtggcgccca cctgaacgca caggataagg aaggggacac ggctctgcac    660

gaggccgtgc ggcacggcag ctacaaagcc atgaagctac tgctgctcta tggggccgag    720

ctgggggtgc ggaacgcggc ctccgtgacc ccggtgcagc tggctcgaga ctggcagcgc    780

ggcatccggg aggccctgca ggcccacgtg gcgcatcccc gcacccggtg ctgaccgcag    840

caccgccccc cgccgcgcct ttcgcactgc caccattcca tcctgtgccc cgcccccgcg    900

tctgcacctc tgtggttcct gccctcagcc ctggttcctc cctctctggc ctgtgccgcc    960

tcagcagccc tggcagaact gaagagcggc accgggccca gcaggcaaag agagaggcct   1020

ccctggcttc gagtgtcagg ggagccgcgt tccctcccag ggctggagca gaggaccaca   1080

aggcagcaga aagcgcgggt ccagatgagg gccaggaagg ggaggagagt gagggccaag   1140

aacgagcctt aagggagcag tcccaagctg gagccaccca gggctgggtc tgggagtcct   1200

cagtgtccac ttgtcccagg ttagggggct tgccttgctc tctccagggc cagtctgtgt   1260

gtgtggggac tcagcccgtg gccggcagat gccatccagg atgtacaagg tgcagccaag   1320

gcaggccatg caggggccgg gcctgtctgc agctggtgga tgcctgtggg catggctttc   1380

tctggggacc ccattcctgt cagtagcaac cctggcagtg tccggagcgg ctctagacaa   1440

ctttggtcat aggaactctg gaggtgggtt ctggtcatct gaggtggcta ctcaacaggt   1500

ttgaggcccc acagcaacag aagtccagga cccactaggt tgcctcagaa gccctaagac   1560

tgatgagctg gagcgcgcat ttgagagaag cctcgcaccc actgtgtact ggccccgctc   1620

aggccggcct ggcacaccgt tgcctgctgg cggctctcat ggggaagcgc ctgggcactg   1680

gggattgctt gtggcccact caactcttgg ggcagtggcc cgtaacccta gtttgcctga   1740

ggcccttatg tccccttatg ttcctggtac tggagcttga gctcttgcct ggaacgctgc   1800

agctgcaccc accctgcttg atcccacctg ggaggccagg acactgagga gctctgaacc   1860

cagcccacag ggaagcagag gaaggtgagc ccccgccgcc ccccagccct tcccatccct   1920

tccctgctcc ctggtggtct aaggacccaa gctccctaga cttcctcttc caccgtctgt   1980

acgtttcaaa ttacactggt gtaggcctgt actgctggtg gggctgggcc cctaaacgcc   2040

agaaagtgaa tcttaagaag ctctgcccta aactgagaac cacatgctga gggaagggct   2100

gaaaggtgaa ggctcagcct ccctcacatg ggtcctgggt tacattaggt accgggctga   2160

ttgataggca tttggccatg gttccttttc gtctaccttt gggggccttc tcaggcccag   2220

aacaaggctg ttgttactat gtggaaaagc tgaccagtgc tgcacactag gggcacacac   2280

ctttccatga gcagctcctg ccctgtggcg acagccagcg tgcacccaga cgctggtgcc   2340

atggcgaagc aggcgttcaa gaccatggag aagacaactc ctcatctaga aaatgaggac   2400

acctcagtga caaacacacc tttttatacc aatcagtatc ctctgttcat taaaactggc   2460

tatccattac agcctagccg tctttcctgg gccgagagga gcccatgctt cagtcaccag   2520

ggactgtctg atagggccca cgcctgttag ccatgccggc cgacagcaag ataggccgag   2580

tgcagagtgg gcgggatgcg gggtcctggc actaggcttt tgtgcttaag gcacctctgc   2640

tcactgacga caaggtcaaa gagcagtggt tctccacctc agctgcttat cagaatcacc   2700

aggaaggttt aaaaagtcct gatgtccaga ccctaagtca gaagccctga ggggaggatc   2760

caggtattct catgcagagg ccatgcttgt ctatgtggga aatcctagga atctacagaa   2820

agcagacaac tagggagtcc agcaaaatct cgggtgcaag ataaacacac aaaaacctgt   2880

ttctacctcc tagaaatgaa catgtagaca caaaagttaa aaatatgtac tgtttacaat   2940

tgctg                                                               2945


<210>  7908
<211>  263
<212>  PRT
<213>  Homosapiens

<400>  7908

Met Asp Phe Ile Ser Ile Gln Gln Leu Val Ser Gly Glu Arg Val Glu 
1               5                   10                  15      


Gly Lys Val Leu Gly Phe Gly His Gly Val Pro Asp Pro Gly Ala Trp 
            20                  25                  30          


Pro Ser Asp Trp Arg Arg Gly Pro Gln Glu Ala Val Ala Arg Glu Lys 
        35                  40                  45              


Leu Lys Leu Glu Glu Glu Lys Lys Lys Lys Leu Glu Arg Phe Asn Ser 
    50                  55                  60                  


Thr Arg Phe Asn Leu Asp Asn Leu Ala Asp Leu Glu Asn Leu Val Gln 
65                  70                  75                  80  


Arg Arg Lys Lys Arg Leu Arg His Arg Val Pro Pro Arg Lys Pro Glu 
                85                  90                  95      


Pro Leu Val Lys Leu His Arg Thr Ala Leu His Trp Ala Cys Leu Lys 
            100                 105                 110         


Gly His Ser Gln Leu Val Asn Lys Leu Leu Val Ala Gly Ala Thr Val 
        115                 120                 125             


Asp Ala Arg Asp Leu Leu Asp Arg Thr Pro Val Phe Trp Ala Cys Arg 
    130                 135                 140                 


Gly Gly His Leu Val Ile Leu Lys Gln Leu Leu Asn Gln Gly Ala Arg 
145                 150                 155                 160 


Val Asn Ala Arg Asp Lys Ile Gly Ser Thr Pro Leu His Val Ala Val 
                165                 170                 175     


Arg Thr Arg His Pro Asp Cys Leu Glu His Leu Ile Glu Cys Gly Ala 
            180                 185                 190         


His Leu Asn Ala Gln Asp Lys Glu Gly Asp Thr Ala Leu His Glu Ala 
        195                 200                 205             


Val Arg His Gly Ser Tyr Lys Ala Met Lys Leu Leu Leu Leu Tyr Gly 
    210                 215                 220                 


Ala Glu Leu Gly Val Arg Asn Ala Ala Ser Val Thr Pro Val Gln Leu 
225                 230                 235                 240 


Ala Arg Asp Trp Gln Arg Gly Ile Arg Glu Ala Leu Gln Ala His Val 
                245                 250                 255     


Ala His Pro Arg Thr Arg Cys 
            260             


<210>  7909
<211>  2187
<212>  DNA
<213>  Homosapiens

<400>  7909
ttcagctctt ctcactgggg ggtgtgagga acagggggga ccatggactt catcagcatt     60

cagcagttgg taagtggaga aagagttgaa gggaaagtgt tgggatttgg acatggagtt    120

cctgaccctg gagcctggcc tagtgactgg aggaggggcc cccaagaggc tgtggcccgg    180

gagaagctga aattggaaga agagaagaag aagaaacttg aaagatttaa cagtaccaga    240

tttaatctgg ataacctggc tgacttggaa aacttggttc aaagacggaa aaagcgactg    300

agacacagag tcccccccag gaaacctgag cccctggtta agccgcagtc ccaggcccag    360

gtggagcctg tgggcctgga gatgttcctg aaggcagctg ctgagaacca ggagtacctg    420

attgacaagt acttgacaga cggaggggac cccaatgccc atgacaagct ccaccgcacc    480

gccttgcact gggcctgtct gaagggtcac agccagctgg tgaacaagct gctggtggca    540

ggtgccacag tggacgcgcg agacttgctg gacaggacac ctgtgttctg ggcctgccgc    600

ggaggacatc tggtcatcct caaacagctg cttaaccagg gagcccgggt caatgcccgg    660

gacaagatcg ggagcacccc cctgcacgtg gcagtgcgca cccggcaccc cgactgcctg    720

gagcacctca tcgagtgtgg cgcccacctg aacgcacagg ataaggaagg ggacacggct    780

ctgcacgagg ccgtgcggca cggcagctac aaagccatga agctactgct gctctatggg    840

gccgagctgg gggtgcggaa cgcggcctcc gtgaccccgg tgcagctggc tcgagactgg    900

cagcgcggca tccgggaggc cctgcaggcc cacgtggcgc atccccgcac ccggtgctga    960

ccgcagcacc gccccccgcc gcgcctttcg cactgccacc attccatcct gtgccccgcc   1020

cccgcgtctg cacctctgtg gttcctgccc tcagccctgg ttcctccctc tctggcctgt   1080

gccgcctcag cagccctggc agaactgaag agcggcaccg ggcccagcag gcaaagagag   1140

aggcctccct ggcttcgagt gtcaggggag ccgcgttccc tcccagggct ggagcagagg   1200

accacaaggc agcagaaagc gcgggtccag atgagggcca ggaaggggag gagagtgagg   1260

gccaagaacg agccttaagg gagcagtccc aagctggagc cacccagggc tgggtctggg   1320

agtcctcagt gtccacttgt cccaggttag ggggcttgcc ttgctctctc cagggccagt   1380

ctgtgtgtgt ggggactcag cccgtggccg gcagatgcca tccaggatgt acaaggtgca   1440

gccaaggcag gccatgcagg ggccgggcct gtctgcagct ggtggatgcc tgtgggcatg   1500

gctttctctg gggaccccat tcctgtcagt agcaaccctg gcagtgtccg gagcggctct   1560

agacaacttt ggtcatagga actctggagg tgggttctgg tcatctgagg tggctactca   1620

acaggtttga ggccccacag caacagaagt ccaggaccca ctaggttgcc tcagaagccc   1680

taagactgat gagctggagc gcgcatttga gagaagcctc gcacccactg tgtactggcc   1740

ccgctcaggc cggcctggca caccgttgcc tgctggcggc tctcatgggg aagcgcctgg   1800

gcactgggga ttgcttgtgg cccactcaac tcttggggca gtggcccgta accctagttt   1860

gcctgaggcc cttatgtccc cttatgttcc tggtactgga gcttgagctc ttgcctggaa   1920

cgctgcagct gcacccaccc tgcttgatcc cacctgggag gccaggacac tgaggagctc   1980

tgaacccagc ccacagggaa gcagaggaag ctcctgccct gtggcgacag ccagcgtgca   2040

cccagacgct ggtgccatgg cgaagcaggc gttcaagacc atggagaaga caactcctca   2100

tctagaaaat gaggacacct cagtgacaaa cacacctttt tataccaatc agtatcctct   2160

gttcattaaa actggctatc cattaca                                       2187


<210>  7910
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  7910

Met Asp Phe Ile Ser Ile Gln Gln Leu Val Ser Gly Glu Arg Val Glu 
1               5                   10                  15      


Gly Lys Val Leu Gly Phe Gly His Gly Val Pro Asp Pro Gly Ala Trp 
            20                  25                  30          


Pro Ser Asp Trp Arg Arg Gly Pro Gln Glu Ala Val Ala Arg Glu Lys 
        35                  40                  45              


Leu Lys Leu Glu Glu Glu Lys Lys Lys Lys Leu Glu Arg Phe Asn Ser 
    50                  55                  60                  


Thr Arg Phe Asn Leu Asp Asn Leu Ala Asp Leu Glu Asn Leu Val Gln 
65                  70                  75                  80  


Arg Arg Lys Lys Arg Leu Arg His Arg Val Pro Pro Arg Lys Pro Glu 
                85                  90                  95      


Pro Leu Val Lys Pro Gln Ser Gln Ala Gln Val Glu Pro Val Gly Leu 
            100                 105                 110         


Glu Met Phe Leu Lys Ala Ala Ala Glu Asn Gln Glu Tyr Leu Ile Asp 
        115                 120                 125             


Lys Tyr Leu Thr Asp Gly Gly Asp Pro Asn Ala His Asp Lys Leu His 
    130                 135                 140                 


Arg Thr Ala Leu His Trp Ala Cys Leu Lys Gly His Ser Gln Leu Val 
145                 150                 155                 160 


Asn Lys Leu Leu Val Ala Gly Ala Thr Val Asp Ala Arg Asp Leu Leu 
                165                 170                 175     


Asp Arg Thr Pro Val Phe Trp Ala Cys Arg Gly Gly His Leu Val Ile 
            180                 185                 190         


Leu Lys Gln Leu Leu Asn Gln Gly Ala Arg Val Asn Ala Arg Asp Lys 
        195                 200                 205             


Ile Gly Ser Thr Pro Leu His Val Ala Val Arg Thr Arg His Pro Asp 
    210                 215                 220                 


Cys Leu Glu His Leu Ile Glu Cys Gly Ala His Leu Asn Ala Gln Asp 
225                 230                 235                 240 


Lys Glu Gly Asp Thr Ala Leu His Glu Ala Val Arg His Gly Ser Tyr 
                245                 250                 255     


Lys Ala Met Lys Leu Leu Leu Leu Tyr Gly Ala Glu Leu Gly Val Arg 
            260                 265                 270         


Asn Ala Ala Ser Val Thr Pro Val Gln Leu Ala Arg Asp Trp Gln Arg 
        275                 280                 285             


Gly Ile Arg Glu Ala Leu Gln Ala His Val Ala His Pro Arg Thr Arg 
    290                 295                 300                 


Cys 
305 


<210>  7911
<211>  305
<212>  DNA
<213>  Homosapiens

<400>  7911
gctgggcccc taaacgccag aaagtgaatc ttaagaagct ctgccctaaa ctgagaacaa     60

ggctgttgtt actatgtgga aaagctgacc agtgctgcac actaggggca cacacctttc    120

catgagcagc tcctgccctg tggcgacagc cagcgtgcac ccagacgctg gtgccatggc    180

gaagcaggcg ttcaagacca tggagaagac aactcctcat ctagaaaatg aggacacctc    240

agtgacaaac acaccttttt ataccaatca gtatcctctg ttcattaaaa ctggctatcc    300

attac                                                                305


<210>  7912
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  7912

Met Ser Ser Ser Cys Pro Val Ala Thr Ala Ser Val His Pro Asp Ala 
1               5                   10                  15      


Gly Ala Met Ala Lys Gln Ala Phe Lys Thr Met Glu Lys Thr Thr Pro 
            20                  25                  30          


His Leu Glu Asn Glu Asp Thr Ser Val Thr Asn Thr Pro Phe Tyr Thr 
        35                  40                  45              


Asn Gln Tyr Pro Leu Phe Ile Lys Thr Gly Tyr Pro 
    50                  55                  60  


<210>  7913
<211>  1254
<212>  DNA
<213>  Homosapiens

<400>  7913
ttcagctctt ctcactgggg ggtgtgagga acagggggga ccatggactt catcagcatt     60

cagcagttgg taagtggaga aagagttgaa gggaaagtgt tgggatttgg acatggagtt    120

cctgaccctg gagcctggcc tagtgactgg aggaggggcc cccaagaggc tgtggcccgg    180

gagaagctga aattggaaga agagaagaag aagaaacttg aaagatttaa cagtaccaga    240

tttaatctgg ataacctggc tgacttggaa aacttggttc aaagacggaa aaagcgactg    300

agacacagag tcccccccag gaaacctgag cccctggtta agccgcagtc ccaggcccag    360

gtggagcctg tgggcctgga gatgttcctg aaggcagctg ctgagaacca ggagtacctg    420

attgacaagt acttgacaga cggaggggac cccaatgccc atgacaagct ccaccgcacc    480

gccttgcact gggcctgtct gaagggtcac agccagctgg tgaacaagct gctggtggca    540

ggtgccacag tggacgcgcg agacttgctg gacaggacac ctgtgttctg ggcctgccgc    600

ggaggacatc tggtcatcct caaacagctg cttaaccagg gagcccgggt caatgcccgg    660

gacaagatcg ggagcacccc cctgcacgtg gcagtgcgca cccggcaccc cgactgcctg    720

gagcacctca tcgagtgtgg cgcccacctg aacgcacagt ctgtacgttt caaattacac    780

tggtgtaggc ctgtactgct ggtggggctg ggcccctaaa cgccagaaag tgaatcttaa    840

gaagctctgc cctaaactga gaaccacatg ctgagggaag ggctgaaagg tgaaggctca    900

gcctccctca catgggtcct gggttacatt aggtaccggg ctgattgata ggcatttggc    960

catggttcct tttcgtctac ctttgggggc cttctcaggc ccagaacaag gctgttgtta   1020

ctatgtggaa aagctgacca gtgctgcaca ctaggggcac acacctttcc atgagcagct   1080

cctgccctgt ggcgacagcc agcgtgcacc cagacgctgg tgccatggcg aagcaggcgt   1140

tcaagaccat ggagaagaca actcctcatc tagaaaatga ggacacctca gtgacaaaca   1200

caccttttta taccaatcag tatcctctgt tcattaaaac tggctatcca ttac         1254


<210>  7914
<211>  258
<212>  PRT
<213>  Homosapiens

<400>  7914

Met Asp Phe Ile Ser Ile Gln Gln Leu Val Ser Gly Glu Arg Val Glu 
1               5                   10                  15      


Gly Lys Val Leu Gly Phe Gly His Gly Val Pro Asp Pro Gly Ala Trp 
            20                  25                  30          


Pro Ser Asp Trp Arg Arg Gly Pro Gln Glu Ala Val Ala Arg Glu Lys 
        35                  40                  45              


Leu Lys Leu Glu Glu Glu Lys Lys Lys Lys Leu Glu Arg Phe Asn Ser 
    50                  55                  60                  


Thr Arg Phe Asn Leu Asp Asn Leu Ala Asp Leu Glu Asn Leu Val Gln 
65                  70                  75                  80  


Arg Arg Lys Lys Arg Leu Arg His Arg Val Pro Pro Arg Lys Pro Glu 
                85                  90                  95      


Pro Leu Val Lys Pro Gln Ser Gln Ala Gln Val Glu Pro Val Gly Leu 
            100                 105                 110         


Glu Met Phe Leu Lys Ala Ala Ala Glu Asn Gln Glu Tyr Leu Ile Asp 
        115                 120                 125             


Lys Tyr Leu Thr Asp Gly Gly Asp Pro Asn Ala His Asp Lys Leu His 
    130                 135                 140                 


Arg Thr Ala Leu His Trp Ala Cys Leu Lys Gly His Ser Gln Leu Val 
145                 150                 155                 160 


Asn Lys Leu Leu Val Ala Gly Ala Thr Val Asp Ala Arg Asp Leu Leu 
                165                 170                 175     


Asp Arg Thr Pro Val Phe Trp Ala Cys Arg Gly Gly His Leu Val Ile 
            180                 185                 190         


Leu Lys Gln Leu Leu Asn Gln Gly Ala Arg Val Asn Ala Arg Asp Lys 
        195                 200                 205             


Ile Gly Ser Thr Pro Leu His Val Ala Val Arg Thr Arg His Pro Asp 
    210                 215                 220                 


Cys Leu Glu His Leu Ile Glu Cys Gly Ala His Leu Asn Ala Gln Ser 
225                 230                 235                 240 


Val Arg Phe Lys Leu His Trp Cys Arg Pro Val Leu Leu Val Gly Leu 
                245                 250                 255     


Gly Pro 
        


<210>  7915
<211>  2470
<212>  DNA
<213>  Homosapiens

<400>  7915
ttcagctctt ctcactgggg ggtgtgagga acagggggga ccatggactt catcagcatt     60

cagcagttgg taagtggaga aagagttgaa gggaaagtgt tgggatttgg acatggagtt    120

cctgaccctg gagcctggcc tagtgactgg aggaggggcc cccaagaggc tgtggcccgg    180

gagaagctga aattggaaga agagaagaag aagaaacttg aaagatttaa cagtaccaga    240

tttaatctgg ataacctggc tgacttggaa aacttggttc aaagacggaa aaagcgactg    300

agacacagag tcccccccag gaaacctgag cccctggtta agctccaccg caccgccttg    360

cactgggcct gtctgaaggg tcacagccag ctggtgaaca agctgctggt ggcaggtgcc    420

acagtggacg cgcgagactt gctggacagg acacctgtgt tctgggcctg ccgcggagga    480

catctggtca tcctcaaaca gctgcttaac cagggagccc gggtcaatgc ccgggacaag    540

atcgggagca cccccctgca cgtggcagtg cgcacccggc accccgactg cctggagcac    600

ctcatcgagt gtggcgccca cctgaacgca caggataagg aaggggacac ggctctgcac    660

gaggccgtgc ggcacggcag ctacaaagcc atgaagctac tgctgctcta tggggccgag    720

ctgggggtgc ggaacgcggc ctccgtgacc ccggtgcagc tggctcgaga ctggcagcgc    780

ggcatccggg aggccctgca ggcccacgtg gcgcatcccc gcacccggtg ctgaccgcag    840

caccgccccc cgccgcgcct ttcgcactgc caccattcca tcctgtgccc cgcccccgcg    900

tctgcacctc tgtggttcct gccctcagcc ctggttcctc cctctctggc ctgtgccgcc    960

tcagcagccc tggcagaact gaagagcggc accgggccca gcaggcaaag agagaggcct   1020

ccctggcttc gagtgtcagg ggagccgcgt tccctcccag ggctggagca gaggaccaca   1080

aggcagcaga aagcgcgggt ccagatgagg gccaggaagg ggaggagagt gagggccaag   1140

aacgagcctt aagggagcag tcccaagctg gagccaccca gggctgggtc tgggagtcct   1200

cagtgtccac ttgtcccagg ttagggggct tgccttgctc tctccagggc cagtctgtgt   1260

gtgtggggac tcagcccgtg gccggcagat gccatccagg atgtacaagg tgcagccaag   1320

gcaggccatg caggggccgg gcctgtctgc agctggtgga tgcctgtggg catggctttc   1380

tctggggacc ccattcctgt cagtagcaac cctggcagtg tccggagcgg ctctagacaa   1440

ctttggtcat aggaactctg gaggtgggtt ctggtcatct gaggtggcta ctcaacaggt   1500

ttgaggcccc acagcaacag aagtccagga cccactaggt tgcctcagaa gccctaagac   1560

tgatgagctg gagcgcgcat ttgagagaag cctcgcaccc actgtgtact ggccccgctc   1620

aggccggcct ggcacaccgt tgcctgctgg cggctctcat ggggaagcgc ctgggcactg   1680

gggattgctt gtggcccact caactcttgg ggcagtggcc cgtaacccta gtttgcctga   1740

ggcccttatg tccccttatg ttcctggtac tggagcttga gctcttgcct ggaacgctgc   1800

agctgcaccc accctgcttg atcccacctg ggaggccagg acactgagga gctctgaacc   1860

cagcccacag ggaagcagag gaaggtgagc ccccgccgcc ccccagccct tcccatccct   1920

tccctgctcc ctggtggtct aaggacccaa gctccctaga cttcctcttc caccgtctgt   1980

acgtttcaaa ttacactggt gtaggcctgt actgctggtg gggctgggcc cctaaacgcc   2040

agaaagtgaa tcttaagaag ctctgcccta aactgagaac cacatgctga gggaagggct   2100

gaaaggtgaa ggctcagcct ccctcacatg ggtcctgggt tacattaggt accgggctga   2160

ttgataggca tttggccatg gttccttttc gtctaccttt gggggccttc tcaggcccag   2220

aacaaggctg ttgttactat gtggaaaagc tgaccagtgc tgcacactag gggcacacac   2280

ctttccatga gcagctcctg ccctgtggcg acagccagcg tgcacccaga cgctggtgcc   2340

atggcgaagc aggcgttcaa gaccatggag aagacaactc ctcatctaga aaatgaggac   2400

acctcagtga caaacacacc tttttatacc aatcagtatc ctctgttcat taaaactggc   2460

tatccattac                                                          2470


<210>  7916
<211>  263
<212>  PRT
<213>  Homosapiens

<400>  7916

Met Asp Phe Ile Ser Ile Gln Gln Leu Val Ser Gly Glu Arg Val Glu 
1               5                   10                  15      


Gly Lys Val Leu Gly Phe Gly His Gly Val Pro Asp Pro Gly Ala Trp 
            20                  25                  30          


Pro Ser Asp Trp Arg Arg Gly Pro Gln Glu Ala Val Ala Arg Glu Lys 
        35                  40                  45              


Leu Lys Leu Glu Glu Glu Lys Lys Lys Lys Leu Glu Arg Phe Asn Ser 
    50                  55                  60                  


Thr Arg Phe Asn Leu Asp Asn Leu Ala Asp Leu Glu Asn Leu Val Gln 
65                  70                  75                  80  


Arg Arg Lys Lys Arg Leu Arg His Arg Val Pro Pro Arg Lys Pro Glu 
                85                  90                  95      


Pro Leu Val Lys Leu His Arg Thr Ala Leu His Trp Ala Cys Leu Lys 
            100                 105                 110         


Gly His Ser Gln Leu Val Asn Lys Leu Leu Val Ala Gly Ala Thr Val 
        115                 120                 125             


Asp Ala Arg Asp Leu Leu Asp Arg Thr Pro Val Phe Trp Ala Cys Arg 
    130                 135                 140                 


Gly Gly His Leu Val Ile Leu Lys Gln Leu Leu Asn Gln Gly Ala Arg 
145                 150                 155                 160 


Val Asn Ala Arg Asp Lys Ile Gly Ser Thr Pro Leu His Val Ala Val 
                165                 170                 175     


Arg Thr Arg His Pro Asp Cys Leu Glu His Leu Ile Glu Cys Gly Ala 
            180                 185                 190         


His Leu Asn Ala Gln Asp Lys Glu Gly Asp Thr Ala Leu His Glu Ala 
        195                 200                 205             


Val Arg His Gly Ser Tyr Lys Ala Met Lys Leu Leu Leu Leu Tyr Gly 
    210                 215                 220                 


Ala Glu Leu Gly Val Arg Asn Ala Ala Ser Val Thr Pro Val Gln Leu 
225                 230                 235                 240 


Ala Arg Asp Trp Gln Arg Gly Ile Arg Glu Ala Leu Gln Ala His Val 
                245                 250                 255     


Ala His Pro Arg Thr Arg Cys 
            260             


<210>  7917
<211>  886
<212>  DNA
<213>  Homosapiens

<400>  7917
ggtgctcggc gtacagcaga cgctggagga gatggacttc gagaaggctg ctgagagggg     60

tcacggggac atctgctccc tcctcctgca acacagccca gccctgaagg ccatccggga    120

ccgaaaggca cggctagcat gtgacctgct gccttgcaac agtgacctgc gggacctgct    180

atccagctga gccgccaccc tatctccagc tgcctttaaa gggtaagtgg agaaagagtt    240

gaagggaaag tgttgggatt tggacatgga gttcctgacc ctggagcctg gcctagtgac    300

tggaggaggg gcccccaaga ggctgtggcc cgggagaagc tgaaattgga agaagagaag    360

aagaagaaac ttgaaagatt taacagtacc agatttaatc tggataacct ggctgacttg    420

gaaaacttgg ttcaaagacg gaaaaagcga ctgagacaca gagtcccccc caggaaacct    480

gagcccctgg ttaagccgca gtcccaggcc caggtggagc ctgtgggcct ggagatgttc    540

ctgaaggcag ctgctgagaa ccaggagtac ctgattgaca agtacttgac agacggaggg    600

gaccccaatg cccatgacaa gctccaccgc accgccttgc actgggcctg tctgaagggt    660

cacagccagc tggtgaacaa gctgctggtg gcaggtgcca cagtggacgc gcgagacttg    720

ctggacagga cacctgtgtt ctgggcctgc cgcggaggac atctggtcat cctcaaacag    780

ctgcttaacc agggagcccg ggtcaatgcc cgggacaaga tcgggagcac ccccctgcac    840

gtggcagtgc gcacccggca ccccgactgc ctggagcacc tcatcg                   886


<210>  7918
<211>  116
<212>  PRT
<213>  Homosapiens

<400>  7918

Met Phe Leu Lys Ala Ala Ala Glu Asn Gln Glu Tyr Leu Ile Asp Lys 
1               5                   10                  15      


Tyr Leu Thr Asp Gly Gly Asp Pro Asn Ala His Asp Lys Leu His Arg 
            20                  25                  30          


Thr Ala Leu His Trp Ala Cys Leu Lys Gly His Ser Gln Leu Val Asn 
        35                  40                  45              


Lys Leu Leu Val Ala Gly Ala Thr Val Asp Ala Arg Asp Leu Leu Asp 
    50                  55                  60                  


Arg Thr Pro Val Phe Trp Ala Cys Arg Gly Gly His Leu Val Ile Leu 
65                  70                  75                  80  


Lys Gln Leu Leu Asn Gln Gly Ala Arg Val Asn Ala Arg Asp Lys Ile 
                85                  90                  95      


Gly Ser Thr Pro Leu His Val Ala Val Arg Thr Arg His Pro Asp Cys 
            100                 105                 110         


Leu Glu His Leu 
        115     


<210>  7919
<211>  726
<212>  DNA
<213>  Homosapiens

<400>  7919
ctcgcatccc agcgcggtgc tcggcgtaca gcagacgctg gaggagatgg acttcgagag     60

ggcactatgc cagccgcaat gggcactacg ctgtgtgcca gttcctgctg gaaagcggag    120

ctaagtgtga tgcccagacc cacgggggtg ccactgctct gcaccgagcc agctactgcg    180

ggcacactga aatcgcgcgg ctcctgctat cacatgggtc caaccccagg gtggtggatg    240

acgacggcat gaccagtctg cataaggctg ctgagagggg tcacggggac atctgctccc    300

tcctcctgca acacagccca gccctgaagg ccatccggga ccgaaaggca cggctagcat    360

gtgacctgct gccttgcaac agtgacctgc gggacctgct atccagctga gccgccaccc    420

tatctccagc tgcctttaaa gggtacacag accagttctc caagcccctg ccttggtcag    480

catccatgct gctgggcagg gaactgaggc cagaccaccc aggaagagcc ccagtctggt    540

cactgtggaa gcgagggagt agatttggtg tggctaaaag tgtttaagac tggacagatg    600

atcatattct aaattagttc atatgagaca tctatttatt tggaaaaaaa taaagttata    660

tccttacctc atcccacacc caaagataaa ttgcaagatt aaagatctaa atataaaaac    720

acaaaa                                                               726


<210>  7920
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  7920

Met Thr Ser Leu His Lys Ala Ala Glu Arg Gly His Gly Asp Ile Cys 
1               5                   10                  15      


Ser Leu Leu Leu Gln His Ser Pro Ala Leu Lys Ala Ile Arg Asp Arg 
            20                  25                  30          


Lys Ala Arg Leu Ala Cys Asp Leu Leu Pro Cys Asn Ser Asp Leu Arg 
        35                  40                  45              


Asp Leu Leu Ser Ser 
    50              


<210>  7921
<211>  976
<212>  DNA
<213>  Homosapiens

<400>  7921
gcggacgccg agcggccaga tcagggacgc ggggcgggcc ctgcgtccgc ccctcccgcc     60

gaggctgagc ctgagacccg gggcggatcg actgacgccg gggccgggat ggcgacgcct    120

cggccctgcg cggacgggcc ctgctgctcg catcccagcg cggtgctcgg cgtacagcag    180

acgctggagg agatggactt cgagagggga atctggtcgg cagccctgaa tggagacctg    240

ggccgagtga agcatttaat ccagaaggcc gaggacccaa gtcagcccga ctcggccggc    300

tacactgcgc tgcactatgc cagccgcaat gggcactacg ctgtgtgcca gttcctgctg    360

gaaagcggag ctaagtgtga tgcccagacc cacgggggtg ccactgctct gcaccgagcc    420

agctactgcg ggcacactga aatcgcgcgg ctcctgctat cacatgggtc caaccccagg    480

gtggtggatg acgacggcat gaccagtctg cataaggctg ctgagagggg tcacggggac    540

atctgctccc tcctcctgca acacagccca gccctgaagg ccatccggga ccgaaaggca    600

cggctagcat gtgacctgct gccttgcaac agtgacctgc gggacctgct atccagctga    660

gccgccaccc tatctccagc tgcctttaaa gggtacacag accagttctc caagcccctg    720

ccttggtcag catccatgct gctgggcagg gaactgaggc cagaccaccc aggaagagcc    780

ccagtctggt cactgtggaa gcgagggagt agatttggtg tggctaaaag tgtttaagac    840

tggacagatg atcatattct aaattagttc atatgagaca tctatttatt tggaaaaaaa    900

taaagttata tccttacctc atcccacacc caaagataaa ttgcaagatt aaagatctaa    960

atataaaaac acaaaa                                                    976


<210>  7922
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  7922

Met Ala Thr Pro Arg Pro Cys Ala Asp Gly Pro Cys Cys Ser His Pro 
1               5                   10                  15      


Ser Ala Val Leu Gly Val Gln Gln Thr Leu Glu Glu Met Asp Phe Glu 
            20                  25                  30          


Arg Gly Ile Trp Ser Ala Ala Leu Asn Gly Asp Leu Gly Arg Val Lys 
        35                  40                  45              


His Leu Ile Gln Lys Ala Glu Asp Pro Ser Gln Pro Asp Ser Ala Gly 
    50                  55                  60                  


Tyr Thr Ala Leu His Tyr Ala Ser Arg Asn Gly His Tyr Ala Val Cys 
65                  70                  75                  80  


Gln Phe Leu Leu Glu Ser Gly Ala Lys Cys Asp Ala Gln Thr His Gly 
                85                  90                  95      


Gly Ala Thr Ala Leu His Arg Ala Ser Tyr Cys Gly His Thr Glu Ile 
            100                 105                 110         


Ala Arg Leu Leu Leu Ser His Gly Ser Asn Pro Arg Val Val Asp Asp 
        115                 120                 125             


Asp Gly Met Thr Ser Leu His Lys Ala Ala Glu Arg Gly His Gly Asp 
    130                 135                 140                 


Ile Cys Ser Leu Leu Leu Gln His Ser Pro Ala Leu Lys Ala Ile Arg 
145                 150                 155                 160 


Asp Arg Lys Ala Arg Leu Ala Cys Asp Leu Leu Pro Cys Asn Ser Asp 
                165                 170                 175     


Leu Arg Asp Leu Leu Ser Ser 
            180             


<210>  7923
<211>  675
<212>  DNA
<213>  Homosapiens

<400>  7923
ctcgcatccc agcgcggtgc tcggcgtaca gcagacgctg gaggagatgg acttcgagag     60

ggcactatgc cagccgcaat gggcactacg ctgtgtgcca gttcctgctg gaaagcggag    120

ctaagtgtga tgcccagacc cacgggggtg ccactgctct gcaccgagcc agctactgcg    180

ggcacactga aatcgcgcgg ctcctgctat cacatgggtc caaccccagg gtggtggatg    240

acgacggcat gaccagtctg cataaggctg ctgagagggg tcacggggac atctgctccc    300

tcctcctgca acacagccca gccctgaagg ccatccggga ccgaaaggca cggctagcat    360

gtgacctgct gccttgcaac agtgacctgc gggacctgct atccagctga gccgccaccc    420

tatctccagc tgcctttaaa gggtacacag accagttctc caagcccctg ccttggtcag    480

catccatgct gctgggcagg gaactgaggc cagaccaccc aggaagagcc ccagtctggt    540

cactgtggaa gcgagggagt agatttggtg tggctaaaag tgtttaagac tggacagatg    600

atcatattct aaattagttc atatgagaca tctatttatt tggaaaaaaa taaagttata    660

tccttacctc atccc                                                     675


<210>  7924
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  7924

Met Thr Ser Leu His Lys Ala Ala Glu Arg Gly His Gly Asp Ile Cys 
1               5                   10                  15      


Ser Leu Leu Leu Gln His Ser Pro Ala Leu Lys Ala Ile Arg Asp Arg 
            20                  25                  30          


Lys Ala Arg Leu Ala Cys Asp Leu Leu Pro Cys Asn Ser Asp Leu Arg 
        35                  40                  45              


Asp Leu Leu Ser Ser 
    50              


<210>  7925
<211>  925
<212>  DNA
<213>  Homosapiens

<400>  7925
gcggacgccg agcggccaga tcagggacgc ggggcgggcc ctgcgtccgc ccctcccgcc     60

gaggctgagc ctgagacccg gggcggatcg actgacgccg gggccgggat ggcgacgcct    120

cggccctgcg cggacgggcc ctgctgctcg catcccagcg cggtgctcgg cgtacagcag    180

acgctggagg agatggactt cgagagggga atctggtcgg cagccctgaa tggagacctg    240

ggccgagtga agcatttaat ccagaaggcc gaggacccaa gtcagcccga ctcggccggc    300

tacactgcgc tgcactatgc cagccgcaat gggcactacg ctgtgtgcca gttcctgctg    360

gaaagcggag ctaagtgtga tgcccagacc cacgggggtg ccactgctct gcaccgagcc    420

agctactgcg ggcacactga aatcgcgcgg ctcctgctat cacatgggtc caaccccagg    480

gtggtggatg acgacggcat gaccagtctg cataaggctg ctgagagggg tcacggggac    540

atctgctccc tcctcctgca acacagccca gccctgaagg ccatccggga ccgaaaggca    600

cggctagcat gtgacctgct gccttgcaac agtgacctgc gggacctgct atccagctga    660

gccgccaccc tatctccagc tgcctttaaa gggtacacag accagttctc caagcccctg    720

ccttggtcag catccatgct gctgggcagg gaactgaggc cagaccaccc aggaagagcc    780

ccagtctggt cactgtggaa gcgagggagt agatttggtg tggctaaaag tgtttaagac    840

tggacagatg atcatattct aaattagttc atatgagaca tctatttatt tggaaaaaaa    900

taaagttata tccttacctc atccc                                          925


<210>  7926
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  7926

Met Ala Thr Pro Arg Pro Cys Ala Asp Gly Pro Cys Cys Ser His Pro 
1               5                   10                  15      


Ser Ala Val Leu Gly Val Gln Gln Thr Leu Glu Glu Met Asp Phe Glu 
            20                  25                  30          


Arg Gly Ile Trp Ser Ala Ala Leu Asn Gly Asp Leu Gly Arg Val Lys 
        35                  40                  45              


His Leu Ile Gln Lys Ala Glu Asp Pro Ser Gln Pro Asp Ser Ala Gly 
    50                  55                  60                  


Tyr Thr Ala Leu His Tyr Ala Ser Arg Asn Gly His Tyr Ala Val Cys 
65                  70                  75                  80  


Gln Phe Leu Leu Glu Ser Gly Ala Lys Cys Asp Ala Gln Thr His Gly 
                85                  90                  95      


Gly Ala Thr Ala Leu His Arg Ala Ser Tyr Cys Gly His Thr Glu Ile 
            100                 105                 110         


Ala Arg Leu Leu Leu Ser His Gly Ser Asn Pro Arg Val Val Asp Asp 
        115                 120                 125             


Asp Gly Met Thr Ser Leu His Lys Ala Ala Glu Arg Gly His Gly Asp 
    130                 135                 140                 


Ile Cys Ser Leu Leu Leu Gln His Ser Pro Ala Leu Lys Ala Ile Arg 
145                 150                 155                 160 


Asp Arg Lys Ala Arg Leu Ala Cys Asp Leu Leu Pro Cys Asn Ser Asp 
                165                 170                 175     


Leu Arg Asp Leu Leu Ser Ser 
            180             


<210>  7927
<211>  1036
<212>  DNA
<213>  Homosapiens

<400>  7927
tgccactaca gtcaggccca ctcccaaaaa catcacggtg gtggcgggca cagacctggt     60

gctgccctgc cacctctcct ccaacttggc cctgcccgac tccaaccccg aggagtcatc    120

agtatgaggg gaacccccac cgcgtcggcg ggaagcgtgg gaggtgtagc tcctactttt    180

gcacaggcac cagctacctc agggacatgg cacgggcacc tgctctgtct gggacagata    240

ctgcccagca cccacccggc catgaggacc tgctctgctc agcacgggca ctgccacttg    300

gtgtggctca ccagggcacc agcctcgcag aaggcatctt cctcctctct gtgaatcaca    360

gacacgcggg accccagccg ccaaaacttt tcaaggcaga agtttcaaga tgtgtgtttg    420

tctgtatttg cacatgtgtt tgtgtgtgtg tgtatgtgtg tgtgcacgcg cgtgcgcgct    480

tgtggcatag ccttcctgtt tctgtcaagt cttcccttgg cctgggtcct cctggtgagt    540

cattggagct atgaagggga aggggtcgta tcactttgtc tctcctaccc ccactgcccc    600

gagtgtcggg cagcgatgta catatggagg tggggtggac agggtgctgt gccccttcag    660

agggagtgca gggcttgggg tgggcctagt cctgctccta gggctgtgaa tgttttcagg    720

gtggggggag ggagatggag cctcctgtgt gtttgggggg aagggtgggt ggggcctccc    780

acttggcccc ggggttcagt ggtattttat acttgccttc ttcctgtaca gggctgggaa    840

aggctgtgtg aggggagaga agggagaggg tgggcctgct gtggacaatg gcatactctc    900

ttccagccct aggaggaggg ctcctaacag tgtaacttat tgtgtccccg cgtatttatt    960

tgttgtaaat atttgagtat ttttatattg acaaataaaa tggagaaaat gaaacgattg   1020

ctctgatggg gctaag                                                   1036


<210>  7928
<211>  152
<212>  PRT
<213>  Homosapiens

<400>  7928

Met Cys Val Cys Thr Arg Val Arg Ala Cys Gly Ile Ala Phe Leu Phe 
1               5                   10                  15      


Leu Ser Ser Leu Pro Leu Ala Trp Val Leu Leu Val Ser His Trp Ser 
            20                  25                  30          


Tyr Glu Gly Glu Gly Val Val Ser Leu Cys Leu Ser Tyr Pro His Cys 
        35                  40                  45              


Pro Glu Cys Arg Ala Ala Met Tyr Ile Trp Arg Trp Gly Gly Gln Gly 
    50                  55                  60                  


Ala Val Pro Leu Gln Arg Glu Cys Arg Ala Trp Gly Gly Pro Ser Pro 
65                  70                  75                  80  


Ala Pro Arg Ala Val Asn Val Phe Arg Val Gly Gly Gly Arg Trp Ser 
                85                  90                  95      


Leu Leu Cys Val Trp Gly Glu Gly Trp Val Gly Pro Pro Thr Trp Pro 
            100                 105                 110         


Arg Gly Ser Val Val Phe Tyr Thr Cys Leu Leu Pro Val Gln Gly Trp 
        115                 120                 125             


Glu Arg Leu Cys Glu Gly Arg Glu Gly Arg Gly Trp Ala Cys Cys Gly 
    130                 135                 140                 


Gln Trp His Thr Leu Phe Gln Pro 
145                 150         


<210>  7929
<211>  2644
<212>  DNA
<213>  Homosapiens

<400>  7929
gttcctagtt gccttgtgca atactcttgt ggcatgtttg ctacacctcc tgaactttga     60

tttgtttgcc ttttaccagc tattatgact caaaattgtc ccctagaaca tggaataatg    120

gcagaaagaa agtgtgtggt tgaataaaca cacagattgg catccaccgt tgaaacagga    180

aaacatctta tgttatgctg ctgctgttgt gagggctgat gggccttgaa atgtatttcc    240

tgcactatgt gtgtgtgagt gtgtgtgatt atactttttg gcctcacagc cccatcatcc    300

ctttctaata acgtcacgtc gataaggggc ttaggattgc atctggcctg tgtaagccct    360

ctgagttctg cggttcttag agttcccttt tcagcactat agctctgcct tgttcccttg    420

ttcctccttc tggcgccccg tgctgtgccc cctgcaggag tccaagctgt ccccatgctg    480

cgttctggtc cggccgcccc tcccgtggtg tggccctggc cgacccccct cctgcgcccc    540

gcttttctcg cagaagctgc tctttgccgg ctcccgctct cagctggtgc agctgcccgt    600

ggccgactgc atgaagtatc gctcctgtgc agactgtgtc ctcgcccggg acccctattg    660

cgcctggagc gtcaacacca gccgctgtgt ggccgtgggt ggccactctg gatctctact    720

gatccagcat gtgatgacct cggacacttc aggcatctgc aacctccgtg gcagtaagaa    780

aggtgagctt tttcattccc gtcgcatcgg gctgagccct ggaccagagc tggagtttct    840

gttctcctct tccccagccc tgctttcctg cactaacatg cactctgttt tctctgccac    900

tacagtcagg cccactccca aaaacatcac ggtggtggcg ggcacagacc tggtgctgcc    960

ctgccacctc tcctccaact tggcccatgc ccgctggacc tttgggggcc gggacctgcc   1020

tgcggaacag cccgggtcct tcctctacga tgcccggctc caggccctgg ttgtgatggc   1080

tgcccagccc cgccatgccg gggcctacca ctgcttttca gaggagcagg gggcgcggct   1140

ggctgctgaa ggctaccttg tggctgtcgt ggcaggcccg tcggtgacct tggaggcccg   1200

ggcccccctg gaaaacctgg ggctggtgtg gctggcggtg gtggccctgg gggctgtgtg   1260

cctggtgctg ctgctgctgg tgctgtcatt gcgccggcgg ctgcgggaag agctggagaa   1320

aggggccaag gctactgaga ggaccttggt gtaccccctg gagctgccca aggagcccac   1380

cagtcccccc ttccggccct gtcctgaacc agatgagaaa ctttgggatc ctgtcggtta   1440

ctactattca gatggctccc ttaagatagt acctgggcat gcccggtgcc agcccggtgg   1500

ggggccccct tcgccacctc caggcatccc aggccagcct ctgccttctc caactcggct   1560

tcacctgggg ggtgggcgga actcaaatgc caatggttac gtgcgcttac aactaggagg   1620

ggaggaccgg ggagggctcg ggcaccccct gcctgagctc gcggatgaac tgagacgcaa   1680

actgcagcaa cgccagccac tgcccgactc caaccccgag gagtcatcag tatgagggga   1740

acccccaccg cgtcggcggg aagcgtggga ggtgtagctc ctacttttgc acaggcacca   1800

gctacctcag ggacatggca cgggcacctg ctctgtctgg gacagatact gcccagcacc   1860

cacccggcca tgaggacctg ctctgctcag cacgggcact gccacttggt gtggctcacc   1920

agggcaccag cctcgcagaa ggcatcttcc tcctctctgt gaatcacaga cacgcgggac   1980

cccagccgcc aaaacttttc aaggcagaag tttcaagatg tgtgtttgtc tgtatttgca   2040

catgtgtttg tgtgtgtgtg tatgtgtgtg tgcacgcgcg tgcgcgcttg tggcatagcc   2100

ttcctgtttc tgtcaagtct tcccttggcc tgggtcctcc tggtgagtca ttggagctat   2160

gaaggggaag gggtcgtatc actttgtctc tcctaccccc actgccccga gtgtcgggca   2220

gcgatgtaca tatggaggtg gggtggacag ggtgctgtgc cccttcagag ggagtgcagg   2280

gcttggggtg ggcctagtcc tgctcctagg gctgtgaatg ttttcagggt ggggggaggg   2340

agatggagcc tcctgtgtgt ttggggggaa gggtgggtgg ggcctcccac ttggccccgg   2400

ggttcagtgg tattttatac ttgccttctt cctgtacagg gctgggaaag gctgtgtgag   2460

gggagagaag ggagagggtg ggcctgctgt ggacaatggc atactctctt ccagccctag   2520

gaggagggct cctaacagtg taacttattg tgtccccgcg tatttatttg ttgtaaatat   2580

ttgagtattt ttatattgac aaataaaatg gagaaaatga aacgattgct ctgatggggc   2640

taag                                                                2644


<210>  7930
<211>  374
<212>  PRT
<213>  Homosapiens

<400>  7930

Met Lys Tyr Arg Ser Cys Ala Asp Cys Val Leu Ala Arg Asp Pro Tyr 
1               5                   10                  15      


Cys Ala Trp Ser Val Asn Thr Ser Arg Cys Val Ala Val Gly Gly His 
            20                  25                  30          


Ser Gly Ser Leu Leu Ile Gln His Val Met Thr Ser Asp Thr Ser Gly 
        35                  40                  45              


Ile Cys Asn Leu Arg Gly Ser Lys Lys Gly Glu Leu Phe His Ser Arg 
    50                  55                  60                  


Arg Ile Gly Leu Ser Pro Gly Pro Glu Leu Glu Phe Leu Phe Ser Ser 
65                  70                  75                  80  


Ser Pro Ala Leu Leu Ser Cys Thr Asn Met His Ser Val Phe Ser Ala 
                85                  90                  95      


Thr Thr Val Arg Pro Thr Pro Lys Asn Ile Thr Val Val Ala Gly Thr 
            100                 105                 110         


Asp Leu Val Leu Pro Cys His Leu Ser Ser Asn Leu Ala His Ala Arg 
        115                 120                 125             


Trp Thr Phe Gly Gly Arg Asp Leu Pro Ala Glu Gln Pro Gly Ser Phe 
    130                 135                 140                 


Leu Tyr Asp Ala Arg Leu Gln Ala Leu Val Val Met Ala Ala Gln Pro 
145                 150                 155                 160 


Arg His Ala Gly Ala Tyr His Cys Phe Ser Glu Glu Gln Gly Ala Arg 
                165                 170                 175     


Leu Ala Ala Glu Gly Tyr Leu Val Ala Val Val Ala Gly Pro Ser Val 
            180                 185                 190         


Thr Leu Glu Ala Arg Ala Pro Leu Glu Asn Leu Gly Leu Val Trp Leu 
        195                 200                 205             


Ala Val Val Ala Leu Gly Ala Val Cys Leu Val Leu Leu Leu Leu Val 
    210                 215                 220                 


Leu Ser Leu Arg Arg Arg Leu Arg Glu Glu Leu Glu Lys Gly Ala Lys 
225                 230                 235                 240 


Ala Thr Glu Arg Thr Leu Val Tyr Pro Leu Glu Leu Pro Lys Glu Pro 
                245                 250                 255     


Thr Ser Pro Pro Phe Arg Pro Cys Pro Glu Pro Asp Glu Lys Leu Trp 
            260                 265                 270         


Asp Pro Val Gly Tyr Tyr Tyr Ser Asp Gly Ser Leu Lys Ile Val Pro 
        275                 280                 285             


Gly His Ala Arg Cys Gln Pro Gly Gly Gly Pro Pro Ser Pro Pro Pro 
    290                 295                 300                 


Gly Ile Pro Gly Gln Pro Leu Pro Ser Pro Thr Arg Leu His Leu Gly 
305                 310                 315                 320 


Gly Gly Arg Asn Ser Asn Ala Asn Gly Tyr Val Arg Leu Gln Leu Gly 
                325                 330                 335     


Gly Glu Asp Arg Gly Gly Leu Gly His Pro Leu Pro Glu Leu Ala Asp 
            340                 345                 350         


Glu Leu Arg Arg Lys Leu Gln Gln Arg Gln Pro Leu Pro Asp Ser Asn 
        355                 360                 365             


Pro Glu Glu Ser Ser Val 
    370                 


<210>  7931
<211>  3402
<212>  DNA
<213>  Homosapiens

<400>  7931
tgtgagatgt ttatgatgcc ctcaccatgg tggttttcct tccagccccc atttccgtga     60

ctgtttccct gaagtgcttg cattataccc ttgtgcaata ctctttttgg tttttttttg    120

agatggagtc tcactctgtc acccaggcta gagtgcagtg acgcgatctc agctcactgc    180

aacctccacc tcccaggttg aagctattct tatgcctcag cctcctgagt agctgggatt    240

acaggtgcct gccactatgc ccagctaaag gttttttgtt tttgtttttg ttttctttga    300

gatggagtct cactctgtcg cccaggctgg agtgcggtgg catgatctct gctcactgca    360

acctccacct cccgggttca agcaattctg cctcggcctc ccaagtaact gggactacag    420

gcacgtgcca ccatgcccag ctaatttttt tttttttttt tttttttgag atggagtctc    480

gctctgtcac ccaggctgga gtgcagtggc gcaatctcgg ctcactgcaa gctctgcctc    540

ccaggttcac accattctcc tgcctcagcc ttccatgtag ctgggactac aggctcccat    600

caccacgcct ggctaatttt ttgtattttt agtagagacg gggtttcacc gtgttagcca    660

ggatggtctc gatctcctga ccttgcgatc cgcccgactc agcctcccaa agtgctggga    720

ttacaggcgt gagccactgc gcctggccag ccggctaatt tttgtatttt tagtagagac    780

aaggttttac catgttggcc aggctggtct tgaactccta acctcaagtg atttgcccac    840

ctcagcctcc caaagtgctg ggattccagg catgacctgc tgttcctagt tgccttgtgc    900

aatactcttg tggcatgttt gctacacctc ctgaactttg atttgtttgc cttttaccag    960

ctattatgac tcaaaattgt cccctagaac atggaataat ggcagaaaga aagtgtgtgg   1020

ttgaataaac acacagattg gcatccaccg ttgaaacagg aaaacatctt atgttatgct   1080

gctgctgttg tgagggctga tgggccttga aatgtatttc ctgcactatg tgtgtgtgag   1140

tgtgtgtgat tatacttttt ggcctcacag ccccatcatc cctttctaat aacgtcacgt   1200

cgataagggg cttaggattg catctggcct gtgtaagccc tctgagttct gcggttctta   1260

gagttccctt ttcagcacta tagctctgcc ttgttccctt gttcctcctt ctggcgcccc   1320

gtgctgtgcc ccctgcagga gtccaagctg tccccatgct gcgttctggt ccggccgccc   1380

ctcccgtggt gtggccctgg ccgacccccc tcctgcgccc cgcttttctc gcagaagctg   1440

ctctttgccg gctcccgctc tcagctggtg cagctgcccg tggccgactg catgaagtat   1500

cgctcctgtg cagactgtgt cctcgcccgg gacccctatt gcgcctggag cgtcaacacc   1560

agccgctgtg tggccgtggg tggccactct ggatctctac tgatccagca tgtgatgacc   1620

tcggacactt caggcatctg caacctccgt ggcagtaaga aagtcaggcc cactcccaaa   1680

aacatcacgg tggtggcggg cacagacctg gtgctgccct gccacctctc ctccaacttg   1740

gcccatgccc gctggacctt tgggggccgg gacctgcctg cggaacagcc cgggtccttc   1800

ctctacgatg cccggctcca ggccctggtt gtgatggctg cccagccccg ccatgccggg   1860

gcctaccact gcttttcaga ggagcagggg gcgcggctgg ctgctgaagg ctaccttgtg   1920

gctgtcgtgg caggcccgtc ggtgaccttg gaggcccggg cccccctgga aaacctgggg   1980

ctggtgtggc tggcggtggt ggccctgggg gctgtgtgcc tggtgctgct gctgctggtg   2040

ctgtcattgc gccggcggct gcgggaagag ctggagaaag gggccaaggc tactgagagg   2100

accttggtgt accccctgga gctgcccaag gagcccacca gtcccccctt ccggccctgt   2160

cctgaaccag atgagaaact ttgggatcct gtcggttact actattcaga tggctccctt   2220

aagatagtac ctgggcatgc ccggtgccag cccggtgggg ggcccccttc gccacctcca   2280

ggcatcccag gccagcctct gccttctcca actcggcttc acctgggggg tgggcggaac   2340

tcaaatgcca atggttacgt gcgcttacaa ctaggagggg aggaccgggg agggctcggg   2400

caccccctgc ctgagctcgc ggatgaactg agacgcaaac tgcagcaacg ccagccactg   2460

cccgactcca accccgagga gtcatcagta tgaggggaac ccccaccgcg tcggcgggaa   2520

gcgtgggagg tgtagctcct acttttgcac aggcaccagc tacctcaggg acatggcacg   2580

ggcacctgct ctgtctggga cagatactgc ccagcaccca cccggccatg aggacctgct   2640

ctgctcagca cgggcactgc cacttggtgt ggctcaccag ggcaccagcc tcgcagaagg   2700

catcttcctc ctctctgtga atcacagaca cgcgggaccc cagccgccaa aacttttcaa   2760

ggcagaagtt tcaagatgtg tgtttgtctg tatttgcaca tgtgtttgtg tgtgtgtgta   2820

tgtgtgtgtg cacgcgcgtg cgcgcttgtg gcatagcctt cctgtttctg tcaagtcttc   2880

ccttggcctg ggtcctcctg gtgagtcatt ggagctatga aggggaaggg gtcgtatcac   2940

tttgtctctc ctacccccac tgccccgagt gtcgggcagc gatgtacata tggaggtggg   3000

gtggacaggg tgctgtgccc cttcagaggg agtgcagggc ttggggtggg cctagtcctg   3060

ctcctagggc tgtgaatgtt ttcagggtgg ggggagggag atggagcctc ctgtgtgttt   3120

ggggggaagg gtgggtgggg cctcccactt ggccccgggg ttcagtggta ttttatactt   3180

gccttcttcc tgtacagggc tgggaaaggc tgtgtgaggg gagagaaggg agagggtggg   3240

cctgctgtgg acaatggcat actctcttcc agccctagga ggagggctcc taacagtgta   3300

acttattgtg tccccgcgta tttatttgtt gtaaatattt gagtattttt atattgacaa   3360

ataaaatgga gaaaatgaaa cgattgctct gatggggcta ag                      3402


<210>  7932
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  7932

Met Lys Tyr Arg Ser Cys Ala Asp Cys Val Leu Ala Arg Asp Pro Tyr 
1               5                   10                  15      


Cys Ala Trp Ser Val Asn Thr Ser Arg Cys Val Ala Val Gly Gly His 
            20                  25                  30          


Ser Gly Ser Leu Leu Ile Gln His Val Met Thr Ser Asp Thr Ser Gly 
        35                  40                  45              


Ile Cys Asn Leu Arg Gly Ser Lys Lys Val Arg Pro Thr Pro Lys Asn 
    50                  55                  60                  


Ile Thr Val Val Ala Gly Thr Asp Leu Val Leu Pro Cys His Leu Ser 
65                  70                  75                  80  


Ser Asn Leu Ala His Ala Arg Trp Thr Phe Gly Gly Arg Asp Leu Pro 
                85                  90                  95      


Ala Glu Gln Pro Gly Ser Phe Leu Tyr Asp Ala Arg Leu Gln Ala Leu 
            100                 105                 110         


Val Val Met Ala Ala Gln Pro Arg His Ala Gly Ala Tyr His Cys Phe 
        115                 120                 125             


Ser Glu Glu Gln Gly Ala Arg Leu Ala Ala Glu Gly Tyr Leu Val Ala 
    130                 135                 140                 


Val Val Ala Gly Pro Ser Val Thr Leu Glu Ala Arg Ala Pro Leu Glu 
145                 150                 155                 160 


Asn Leu Gly Leu Val Trp Leu Ala Val Val Ala Leu Gly Ala Val Cys 
                165                 170                 175     


Leu Val Leu Leu Leu Leu Val Leu Ser Leu Arg Arg Arg Leu Arg Glu 
            180                 185                 190         


Glu Leu Glu Lys Gly Ala Lys Ala Thr Glu Arg Thr Leu Val Tyr Pro 
        195                 200                 205             


Leu Glu Leu Pro Lys Glu Pro Thr Ser Pro Pro Phe Arg Pro Cys Pro 
    210                 215                 220                 


Glu Pro Asp Glu Lys Leu Trp Asp Pro Val Gly Tyr Tyr Tyr Ser Asp 
225                 230                 235                 240 


Gly Ser Leu Lys Ile Val Pro Gly His Ala Arg Cys Gln Pro Gly Gly 
                245                 250                 255     


Gly Pro Pro Ser Pro Pro Pro Gly Ile Pro Gly Gln Pro Leu Pro Ser 
            260                 265                 270         


Pro Thr Arg Leu His Leu Gly Gly Gly Arg Asn Ser Asn Ala Asn Gly 
        275                 280                 285             


Tyr Val Arg Leu Gln Leu Gly Gly Glu Asp Arg Gly Gly Leu Gly His 
    290                 295                 300                 


Pro Leu Pro Glu Leu Ala Asp Glu Leu Arg Arg Lys Leu Gln Gln Arg 
305                 310                 315                 320 


Gln Pro Leu Pro Asp Ser Asn Pro Glu Glu Ser Ser Val 
                325                 330             


<210>  7933
<211>  3801
<212>  DNA
<213>  Homosapiens

<400>  7933
ctgtgctcgc atctctggca gcctggattg gggtcctgct ggagtgaagg gtttcctgag     60

gcagggagta ctcatagccg tctgtgcctc ctgctctgct ggactctgat agaggcagtg    120

ggcagcaggg caaagaagga agcagccgcc gaggaagcga aggtggggtg ggggtgccca    180

gccctgcggc cggaggtgcc attgaccctg agagcaagag ccatcagtct gatggcttcc    240

tctggccgga agctgtggct gagatatcct tccttcctcc cagcagcctg gatttgcctc    300

ctcccaggct gggaaaggct agggaggccc aggtggggct gtcagggcca aaggctgttt    360

caaaagtgtc ctttattgcc aatcaggggg tttggctggc atctgcttgt ggcatggggt    420

gctggctctc gtggagcaag actgagggct gtcgagcccc aggggtcctg cccatcagca    480

gccatgctta cccctgcaga gctggccacg gtagtacggc ggttctccca gaccggcatc    540

caggacttcc tgacactgac gctgacggag cccactgggc ttctgtacgt gggcgcccga    600

gaggccctgt ttgccttcag catggaggcc ctggagctgc aaggagcgat ctcctgggag    660

gcccccgtgg agaagaagac tgagtgtatc cagaaaggga agaacaacca gaccgagtgc    720

ttcaacttca tccgcttcct gcagccctac aatgcctccc acctgtacgt ctgtggcacc    780

tacgccttcc agcccaagtg cacctacgtc aacatgctca ccttcacttt ggagcatgga    840

gagtttgaag atgggaaggg caagtgtccc tatgacccag ctaagggcca tgctggcctt    900

cttgtggatg gtgagctgta ctcggccaca ctcaacaact tcctgggcac ggaacccatt    960

atcctgcgta acatggggcc ccaccactcc atgaagacag agtacctggc cttttggctc   1020

aacgaacctc actttgtagg ctctgcctat gtacctgaga gtgtgggcag cttcacgggg   1080

gacgacgaca aggtctactt cttcttcagg gagcgggcag tggagtccga ctgctatgcc   1140

gagcaggtgg tggctcgtgt ggcccgtgtc tgcaagggcg atatgggggg cgcacggacc   1200

ctgcagagga agtggaccac gttcctgaag gcgcggctgg catgctctgc cccgaactgg   1260

cagctctact tcaaccagct gcaggcgatg cacaccctgc aggacacctc ctggcacaac   1320

accaccttct ttggggtttt tcaagcacag tggggtgaca tgtacctgtc ggccatctgt   1380

gagtaccagt tggaagagat ccagcgggtg tttgagggcc cctataagga gtaccatgag   1440

gaagcccaga agtgggaccg ctacactgac cctgtaccca gccctcggcc tggctcgtgc   1500

attaacaact ggcatcggcg ccacggctac accagctccc tggagctacc cgacaacatc   1560

ctcaacttcg tcaagaagca cccgctgatg gaggagcagg tggggcctcg gtggagccgc   1620

cccctgctcg tgaagaaggg caccaacttc acccacctgg tggccgaccg ggttacagga   1680

cttgatggag ccacctatac agtgctgttc attggcacag gagacggctg gctgctcaag   1740

gctgtgagcc tggggccctg ggttcacctg attgaggagc tgcagctgtt tgaccaggag   1800

cccatgagaa gcctggtgct atctcagagc aagaagctgc tctttgccgg ctcccgctct   1860

cagctggtgc agctgcccgt ggccgactgc atgaagtatc gctcctgtgc agactgtgtc   1920

ctcgcccggg acccctattg cgcctggagc gtcaacacca gccgctgtgt ggccgtgggt   1980

ggccactctg gatctctact gatccagcat gtgatgacct cggacacttc aggcatctgc   2040

aacctccgtg gcagtaagaa agtcaggccc actcccaaaa acatcacggt ggtggcgggc   2100

acagacctgg tgctgccctg ccacctctcc tccaacttgg cccatgcccg ctggaccttt   2160

gggggccggg acctgcctgc ggaacagccc gggtccttcc tctacgatgc ccggctccag   2220

gccctggttg tgatggctgc ccagccccgc catgccgggg cctaccactg cttttcagag   2280

gagcaggggg cgcggctggc tgctgaaggc taccttgtgg ctgtcgtggc aggcccgtcg   2340

gtgaccttgg aggcccgggc ccccctggaa aacctggggc tggtgtggct ggcggtggtg   2400

gccctggggg ctgtgtgcct ggtgctgctg ctgctggtgc tgtcattgcg ccggcggctg   2460

cgggaagagc tggagaaagg ggccaaggct actgagagga ccttggtgta ccccctggag   2520

ctgcccaagg agcccaccag tccccccttc cggccctgtc ctgaaccaga tgagaaactt   2580

tgggatcctg tcggttacta ctattcagat ggctccctta agatagtacc tgggcatgcc   2640

cggtgccagc ccggtggggg gcccccttcg ccacctccag gcatcccagg ccagcctctg   2700

ccttctccaa ctcggcttca cctggggggt gggcggaact caaatgccaa tggttacgtg   2760

cgcttacaac taggagggga ggaccgggga gggctcgggc accccctgcc tgagctcgcg   2820

gatgaactga gacgcaaact gcagcaacgc cagccactgc ccgactccaa ccccgaggag   2880

tcatcagtat gaggggaacc cccaccgcgt cggcgggaag cgtgggaggt gtagctccta   2940

cttttgcaca ggcaccagct acctcaggga catggcacgg gcacctgctc tgtctgggac   3000

agatactgcc cagcacccac ccggccatga ggacctgctc tgctcagcac gggcactgcc   3060

acttggtgtg gctcaccagg gcaccagcct cgcagaaggc atcttcctcc tctctgtgaa   3120

tcacagacac gcgggacccc agccgccaaa acttttcaag gcagaagttt caagatgtgt   3180

gtttgtctgt atttgcacat gtgtttgtgt gtgtgtgtat gtgtgtgtgc acgcgcgtgc   3240

gcgcttgtgg catagccttc ctgtttctgt caagtcttcc cttggcctgg gtcctcctgg   3300

tgagtcattg gagctatgaa ggggaagggg tcgtatcact ttgtctctcc tacccccact   3360

gccccgagtg tcgggcagcg atgtacatat ggaggtgggg tggacagggt gctgtgcccc   3420

ttcagaggga gtgcagggct tggggtgggc ctagtcctgc tcctagggct gtgaatgttt   3480

tcagggtggg gggagggaga tggagcctcc tgtgtgtttg gggggaaggg tgggtggggc   3540

ctcccacttg gccccggggt tcagtggtat tttatacttg ccttcttcct gtacagggct   3600

gggaaaggct gtgtgagggg agagaaggga gagggtgggc ctgctgtgga caatggcata   3660

ctctcttcca gccctaggag gagggctcct aacagtgtaa cttattgtgt ccccgcgtat   3720

ttatttgttg taaatatttg agtattttta tattgacaaa taaaatggag aaaatgaaac   3780

gattgctctg atggggctaa g                                             3801


<210>  7934
<211>  886
<212>  PRT
<213>  Homosapiens

<400>  7934

Met Ala Ser Ser Gly Arg Lys Leu Trp Leu Arg Tyr Pro Ser Phe Leu 
1               5                   10                  15      


Pro Ala Ala Trp Ile Cys Leu Leu Pro Gly Trp Glu Arg Leu Gly Arg 
            20                  25                  30          


Pro Arg Trp Gly Cys Gln Gly Gln Arg Leu Phe Gln Lys Cys Pro Leu 
        35                  40                  45              


Leu Pro Ile Arg Gly Phe Gly Trp His Leu Leu Val Ala Trp Gly Ala 
    50                  55                  60                  


Gly Ser Arg Gly Ala Arg Leu Arg Ala Val Glu Pro Gln Gly Ser Cys 
65                  70                  75                  80  


Pro Ser Ala Ala Met Leu Thr Pro Ala Glu Leu Ala Thr Val Val Arg 
                85                  90                  95      


Arg Phe Ser Gln Thr Gly Ile Gln Asp Phe Leu Thr Leu Thr Leu Thr 
            100                 105                 110         


Glu Pro Thr Gly Leu Leu Tyr Val Gly Ala Arg Glu Ala Leu Phe Ala 
        115                 120                 125             


Phe Ser Met Glu Ala Leu Glu Leu Gln Gly Ala Ile Ser Trp Glu Ala 
    130                 135                 140                 


Pro Val Glu Lys Lys Thr Glu Cys Ile Gln Lys Gly Lys Asn Asn Gln 
145                 150                 155                 160 


Thr Glu Cys Phe Asn Phe Ile Arg Phe Leu Gln Pro Tyr Asn Ala Ser 
                165                 170                 175     


His Leu Tyr Val Cys Gly Thr Tyr Ala Phe Gln Pro Lys Cys Thr Tyr 
            180                 185                 190         


Val Asn Met Leu Thr Phe Thr Leu Glu His Gly Glu Phe Glu Asp Gly 
        195                 200                 205             


Lys Gly Lys Cys Pro Tyr Asp Pro Ala Lys Gly His Ala Gly Leu Leu 
    210                 215                 220                 


Val Asp Gly Glu Leu Tyr Ser Ala Thr Leu Asn Asn Phe Leu Gly Thr 
225                 230                 235                 240 


Glu Pro Ile Ile Leu Arg Asn Met Gly Pro His His Ser Met Lys Thr 
                245                 250                 255     


Glu Tyr Leu Ala Phe Trp Leu Asn Glu Pro His Phe Val Gly Ser Ala 
            260                 265                 270         


Tyr Val Pro Glu Ser Val Gly Ser Phe Thr Gly Asp Asp Asp Lys Val 
        275                 280                 285             


Tyr Phe Phe Phe Arg Glu Arg Ala Val Glu Ser Asp Cys Tyr Ala Glu 
    290                 295                 300                 


Gln Val Val Ala Arg Val Ala Arg Val Cys Lys Gly Asp Met Gly Gly 
305                 310                 315                 320 


Ala Arg Thr Leu Gln Arg Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
                325                 330                 335     


Ala Cys Ser Ala Pro Asn Trp Gln Leu Tyr Phe Asn Gln Leu Gln Ala 
            340                 345                 350         


Met His Thr Leu Gln Asp Thr Ser Trp His Asn Thr Thr Phe Phe Gly 
        355                 360                 365             


Val Phe Gln Ala Gln Trp Gly Asp Met Tyr Leu Ser Ala Ile Cys Glu 
    370                 375                 380                 


Tyr Gln Leu Glu Glu Ile Gln Arg Val Phe Glu Gly Pro Tyr Lys Glu 
385                 390                 395                 400 


Tyr His Glu Glu Ala Gln Lys Trp Asp Arg Tyr Thr Asp Pro Val Pro 
                405                 410                 415     


Ser Pro Arg Pro Gly Ser Cys Ile Asn Asn Trp His Arg Arg His Gly 
            420                 425                 430         


Tyr Thr Ser Ser Leu Glu Leu Pro Asp Asn Ile Leu Asn Phe Val Lys 
        435                 440                 445             


Lys His Pro Leu Met Glu Glu Gln Val Gly Pro Arg Trp Ser Arg Pro 
    450                 455                 460                 


Leu Leu Val Lys Lys Gly Thr Asn Phe Thr His Leu Val Ala Asp Arg 
465                 470                 475                 480 


Val Thr Gly Leu Asp Gly Ala Thr Tyr Thr Val Leu Phe Ile Gly Thr 
                485                 490                 495     


Gly Asp Gly Trp Leu Leu Lys Ala Val Ser Leu Gly Pro Trp Val His 
            500                 505                 510         


Leu Ile Glu Glu Leu Gln Leu Phe Asp Gln Glu Pro Met Arg Ser Leu 
        515                 520                 525             


Val Leu Ser Gln Ser Lys Lys Leu Leu Phe Ala Gly Ser Arg Ser Gln 
    530                 535                 540                 


Leu Val Gln Leu Pro Val Ala Asp Cys Met Lys Tyr Arg Ser Cys Ala 
545                 550                 555                 560 


Asp Cys Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Val Asn Thr 
                565                 570                 575     


Ser Arg Cys Val Ala Val Gly Gly His Ser Gly Ser Leu Leu Ile Gln 
            580                 585                 590         


His Val Met Thr Ser Asp Thr Ser Gly Ile Cys Asn Leu Arg Gly Ser 
        595                 600                 605             


Lys Lys Val Arg Pro Thr Pro Lys Asn Ile Thr Val Val Ala Gly Thr 
    610                 615                 620                 


Asp Leu Val Leu Pro Cys His Leu Ser Ser Asn Leu Ala His Ala Arg 
625                 630                 635                 640 


Trp Thr Phe Gly Gly Arg Asp Leu Pro Ala Glu Gln Pro Gly Ser Phe 
                645                 650                 655     


Leu Tyr Asp Ala Arg Leu Gln Ala Leu Val Val Met Ala Ala Gln Pro 
            660                 665                 670         


Arg His Ala Gly Ala Tyr His Cys Phe Ser Glu Glu Gln Gly Ala Arg 
        675                 680                 685             


Leu Ala Ala Glu Gly Tyr Leu Val Ala Val Val Ala Gly Pro Ser Val 
    690                 695                 700                 


Thr Leu Glu Ala Arg Ala Pro Leu Glu Asn Leu Gly Leu Val Trp Leu 
705                 710                 715                 720 


Ala Val Val Ala Leu Gly Ala Val Cys Leu Val Leu Leu Leu Leu Val 
                725                 730                 735     


Leu Ser Leu Arg Arg Arg Leu Arg Glu Glu Leu Glu Lys Gly Ala Lys 
            740                 745                 750         


Ala Thr Glu Arg Thr Leu Val Tyr Pro Leu Glu Leu Pro Lys Glu Pro 
        755                 760                 765             


Thr Ser Pro Pro Phe Arg Pro Cys Pro Glu Pro Asp Glu Lys Leu Trp 
    770                 775                 780                 


Asp Pro Val Gly Tyr Tyr Tyr Ser Asp Gly Ser Leu Lys Ile Val Pro 
785                 790                 795                 800 


Gly His Ala Arg Cys Gln Pro Gly Gly Gly Pro Pro Ser Pro Pro Pro 
                805                 810                 815     


Gly Ile Pro Gly Gln Pro Leu Pro Ser Pro Thr Arg Leu His Leu Gly 
            820                 825                 830         


Gly Gly Arg Asn Ser Asn Ala Asn Gly Tyr Val Arg Leu Gln Leu Gly 
        835                 840                 845             


Gly Glu Asp Arg Gly Gly Leu Gly His Pro Leu Pro Glu Leu Ala Asp 
    850                 855                 860                 


Glu Leu Arg Arg Lys Leu Gln Gln Arg Gln Pro Leu Pro Asp Ser Asn 
865                 870                 875                 880 


Pro Glu Glu Ser Ser Val 
                885     


<210>  7935
<211>  3635
<212>  DNA
<213>  Homosapiens

<400>  7935
cgccgtggtg gcgcggggag cccgagccta ggggcgcgga gccgggcggg gacggagggg     60

cggtggcaga gaggccgcgg agggctggcg ggcgagcgcg ggcaggcggc gacgcggggg    120

caggggtgga cggcggtcag agccgaacgc gagggcggcg cccggggact ggagctgcgc    180

gcaataggac agctggcctg aagctcagag ccggggcgtg cgccatggcc ccacactggg    240

ctgtctggct gctggcagca aggctgtggg gcctgggcat tggggctgag gtgtggtgga    300

accttgtgcc gcgtaagaca gtgtcttctg gggagctggc cacggtagta cggcggttct    360

cccagaccgg catccaggac ttcctgacac tgacgctgac ggagcccact gggcttctgt    420

acgtgggcgc ccgagaggcc ctgtttgcct tcagcatgga ggccctggag ctgcaaggag    480

cgatctcctg ggaggccccc gtggagaaga agactgagtg tatccagaaa gggaagaaca    540

accagaccga gtgcttcaac ttcatccgct tcctgcagcc ctacaatgcc tcccacctgt    600

acgtctgtgg cacctacgcc ttccagccca agtgcaccta cgtcaacatg ctcaccttca    660

ctttggagca tggagagttt gaagatggga agggcaagtg tccctatgac ccagctaagg    720

gccatgctgg ccttcttgtg gatggtgagc tgtactcggc cacactcaac aacttcctgg    780

gcacggaacc cattatcctg cgtaacatgg ggccccacca ctccatgaag acagagtacc    840

tggccttttg gctcaacgaa cctcactttg taggctctgc ctatgtacct gagagtgtgg    900

gcagcttcac gggggacgac gacaaggtct acttcttctt cagggagcgg gcagtggagt    960

ccgactgcta tgccgagcag gtggtggctc gtgtggcccg tgtctgcaag ggcgatatgg   1020

ggggcgcacg gaccctgcag aggaagtgga ccacgttcct gaaggcgcgg ctggcatgct   1080

ctgccccgaa ctggcagctc tacttcaacc agctgcaggc gatgcacacc ctgcaggaca   1140

cctcctggca caacaccacc ttctttgggg tttttcaagc acagtggggt gacatgtacc   1200

tgtcggccat ctgtgagtac cagttggaag agatccagcg ggtgtttgag ggcccctata   1260

aggagtacca tgaggaagcc cagaagtggg accgctacac tgaccctgta cccagccctc   1320

ggcctggctc gtgcattaac aactggcatc ggcgccacgg ctacaccagc tccctggagc   1380

tacccgacaa catcctcaac ttcgtcaaga agcacccgct gatggaggag caggtggggc   1440

ctcggtggag ccgccccctg ctcgtgaaga agggcaccaa cttcacccac ctggtggccg   1500

accgggttac aggacttgat ggagccacct atacagtgct gttcattggc acaggagacg   1560

gctggctgct caaggctgtg agcctggggc cctgggttca cctgattgag gagctgcagc   1620

tgtttgacca ggagcccatg agaagcctgg tgctatctca gagcaagaag ctgctctttg   1680

ccggctcccg ctctcagctg gtgcagctgc ccgtggccga ctgcatgaag tatcgctcct   1740

gtgcagactg tgtcctcgcc cgggacccct attgcgcctg gagcgtcaac accagccgct   1800

gtgtggccgt gggtggccac tctggatctc tactgatcca gcatgtgatg acctcggaca   1860

cttcaggcat ctgcaacctc cgtggcagta agaaagtcag gcccactccc aaaaacatca   1920

cggtggtggc gggcacagac ctggtgctgc cctgccacct ctcctccaac ttggcccatg   1980

cccgctggac ctttgggggc cgggacctgc ctgcggaaca gcccgggtcc ttcctctacg   2040

atgcccggct ccaggccctg gttgtgatgg ctgcccagcc ccgccatgcc ggggcctacc   2100

actgcttttc agaggagcag ggggcgcggc tggctgctga aggctacctt gtggctgtcg   2160

tggcaggccc gtcggtgacc ttggaggccc gggcccccct ggaaaacctg gggctggtgt   2220

ggctggcggt ggtggccctg ggggctgtgt gcctggtgct gctgctgctg gtgctgtcat   2280

tgcgccggcg gctgcgggaa gagctggaga aaggggccaa ggctactgag aggaccttgg   2340

tgtaccccct ggagctgccc aaggagccca ccagtccccc cttccggccc tgtcctgaac   2400

cagatgagaa actttgggat cctgtcggtt actactattc agatggctcc cttaagatag   2460

tacctgggca tgcccggtgc cagcccggtg gggggccccc ttcgccacct ccaggcatcc   2520

caggccagcc tctgccttct ccaactcggc ttcacctggg gggtgggcgg aactcaaatg   2580

ccaatggtta cgtgcgctta caactaggag gggaggaccg gggagggctc gggcaccccc   2640

tgcctgagct cgcggatgaa ctgagacgca aactgcagca acgccagcca ctgcccgact   2700

ccaaccccga ggagtcatca gtatgagggg aacccccacc gcgtcggcgg gaagcgtggg   2760

aggtgtagct cctacttttg cacaggcacc agctacctca gggacatggc acgggcacct   2820

gctctgtctg ggacagatac tgcccagcac ccacccggcc atgaggacct gctctgctca   2880

gcacgggcac tgccacttgg tgtggctcac cagggcacca gcctcgcaga aggcatcttc   2940

ctcctctctg tgaatcacag acacgcggga ccccagccgc caaaactttt caaggcagaa   3000

gtttcaagat gtgtgtttgt ctgtatttgc acatgtgttt gtgtgtgtgt gtatgtgtgt   3060

gtgcacgcgc gtgcgcgctt gtggcatagc cttcctgttt ctgtcaagtc ttcccttggc   3120

ctgggtcctc ctggtgagtc attggagcta tgaaggggaa ggggtcgtat cactttgtct   3180

ctcctacccc cactgccccg agtgtcgggc agcgatgtac atatggaggt ggggtggaca   3240

gggtgctgtg ccccttcaga gggagtgcag ggcttggggt gggcctagtc ctgctcctag   3300

ggctgtgaat gttttcaggg tggggggagg gagatggagc ctcctgtgtg tttgggggga   3360

agggtgggtg gggcctccca cttggccccg gggttcagtg gtattttata cttgccttct   3420

tcctgtacag ggctgggaaa ggctgtgtga ggggagagaa gggagagggt gggcctgctg   3480

tggacaatgg catactctct tccagcccta ggaggagggc tcctaacagt gtaacttatt   3540

gtgtccccgc gtatttattt gttgtaaata tttgagtatt tttatattga caaataaaat   3600

ggagaaaatg aaacgattgc tctgatgggg ctaag                              3635


<210>  7936
<211>  833
<212>  PRT
<213>  Homosapiens

<400>  7936

Met Ala Pro His Trp Ala Val Trp Leu Leu Ala Ala Arg Leu Trp Gly 
1               5                   10                  15      


Leu Gly Ile Gly Ala Glu Val Trp Trp Asn Leu Val Pro Arg Lys Thr 
            20                  25                  30          


Val Ser Ser Gly Glu Leu Ala Thr Val Val Arg Arg Phe Ser Gln Thr 
        35                  40                  45              


Gly Ile Gln Asp Phe Leu Thr Leu Thr Leu Thr Glu Pro Thr Gly Leu 
    50                  55                  60                  


Leu Tyr Val Gly Ala Arg Glu Ala Leu Phe Ala Phe Ser Met Glu Ala 
65                  70                  75                  80  


Leu Glu Leu Gln Gly Ala Ile Ser Trp Glu Ala Pro Val Glu Lys Lys 
                85                  90                  95      


Thr Glu Cys Ile Gln Lys Gly Lys Asn Asn Gln Thr Glu Cys Phe Asn 
            100                 105                 110         


Phe Ile Arg Phe Leu Gln Pro Tyr Asn Ala Ser His Leu Tyr Val Cys 
        115                 120                 125             


Gly Thr Tyr Ala Phe Gln Pro Lys Cys Thr Tyr Val Asn Met Leu Thr 
    130                 135                 140                 


Phe Thr Leu Glu His Gly Glu Phe Glu Asp Gly Lys Gly Lys Cys Pro 
145                 150                 155                 160 


Tyr Asp Pro Ala Lys Gly His Ala Gly Leu Leu Val Asp Gly Glu Leu 
                165                 170                 175     


Tyr Ser Ala Thr Leu Asn Asn Phe Leu Gly Thr Glu Pro Ile Ile Leu 
            180                 185                 190         


Arg Asn Met Gly Pro His His Ser Met Lys Thr Glu Tyr Leu Ala Phe 
        195                 200                 205             


Trp Leu Asn Glu Pro His Phe Val Gly Ser Ala Tyr Val Pro Glu Ser 
    210                 215                 220                 


Val Gly Ser Phe Thr Gly Asp Asp Asp Lys Val Tyr Phe Phe Phe Arg 
225                 230                 235                 240 


Glu Arg Ala Val Glu Ser Asp Cys Tyr Ala Glu Gln Val Val Ala Arg 
                245                 250                 255     


Val Ala Arg Val Cys Lys Gly Asp Met Gly Gly Ala Arg Thr Leu Gln 
            260                 265                 270         


Arg Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ala Cys Ser Ala Pro 
        275                 280                 285             


Asn Trp Gln Leu Tyr Phe Asn Gln Leu Gln Ala Met His Thr Leu Gln 
    290                 295                 300                 


Asp Thr Ser Trp His Asn Thr Thr Phe Phe Gly Val Phe Gln Ala Gln 
305                 310                 315                 320 


Trp Gly Asp Met Tyr Leu Ser Ala Ile Cys Glu Tyr Gln Leu Glu Glu 
                325                 330                 335     


Ile Gln Arg Val Phe Glu Gly Pro Tyr Lys Glu Tyr His Glu Glu Ala 
            340                 345                 350         


Gln Lys Trp Asp Arg Tyr Thr Asp Pro Val Pro Ser Pro Arg Pro Gly 
        355                 360                 365             


Ser Cys Ile Asn Asn Trp His Arg Arg His Gly Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Glu Leu Pro Asp Asn Ile Leu Asn Phe Val Lys Lys His Pro Leu Met 
385                 390                 395                 400 


Glu Glu Gln Val Gly Pro Arg Trp Ser Arg Pro Leu Leu Val Lys Lys 
                405                 410                 415     


Gly Thr Asn Phe Thr His Leu Val Ala Asp Arg Val Thr Gly Leu Asp 
            420                 425                 430         


Gly Ala Thr Tyr Thr Val Leu Phe Ile Gly Thr Gly Asp Gly Trp Leu 
        435                 440                 445             


Leu Lys Ala Val Ser Leu Gly Pro Trp Val His Leu Ile Glu Glu Leu 
    450                 455                 460                 


Gln Leu Phe Asp Gln Glu Pro Met Arg Ser Leu Val Leu Ser Gln Ser 
465                 470                 475                 480 


Lys Lys Leu Leu Phe Ala Gly Ser Arg Ser Gln Leu Val Gln Leu Pro 
                485                 490                 495     


Val Ala Asp Cys Met Lys Tyr Arg Ser Cys Ala Asp Cys Val Leu Ala 
            500                 505                 510         


Arg Asp Pro Tyr Cys Ala Trp Ser Val Asn Thr Ser Arg Cys Val Ala 
        515                 520                 525             


Val Gly Gly His Ser Gly Ser Leu Leu Ile Gln His Val Met Thr Ser 
    530                 535                 540                 


Asp Thr Ser Gly Ile Cys Asn Leu Arg Gly Ser Lys Lys Val Arg Pro 
545                 550                 555                 560 


Thr Pro Lys Asn Ile Thr Val Val Ala Gly Thr Asp Leu Val Leu Pro 
                565                 570                 575     


Cys His Leu Ser Ser Asn Leu Ala His Ala Arg Trp Thr Phe Gly Gly 
            580                 585                 590         


Arg Asp Leu Pro Ala Glu Gln Pro Gly Ser Phe Leu Tyr Asp Ala Arg 
        595                 600                 605             


Leu Gln Ala Leu Val Val Met Ala Ala Gln Pro Arg His Ala Gly Ala 
    610                 615                 620                 


Tyr His Cys Phe Ser Glu Glu Gln Gly Ala Arg Leu Ala Ala Glu Gly 
625                 630                 635                 640 


Tyr Leu Val Ala Val Val Ala Gly Pro Ser Val Thr Leu Glu Ala Arg 
                645                 650                 655     


Ala Pro Leu Glu Asn Leu Gly Leu Val Trp Leu Ala Val Val Ala Leu 
            660                 665                 670         


Gly Ala Val Cys Leu Val Leu Leu Leu Leu Val Leu Ser Leu Arg Arg 
        675                 680                 685             


Arg Leu Arg Glu Glu Leu Glu Lys Gly Ala Lys Ala Thr Glu Arg Thr 
    690                 695                 700                 


Leu Val Tyr Pro Leu Glu Leu Pro Lys Glu Pro Thr Ser Pro Pro Phe 
705                 710                 715                 720 


Arg Pro Cys Pro Glu Pro Asp Glu Lys Leu Trp Asp Pro Val Gly Tyr 
                725                 730                 735     


Tyr Tyr Ser Asp Gly Ser Leu Lys Ile Val Pro Gly His Ala Arg Cys 
            740                 745                 750         


Gln Pro Gly Gly Gly Pro Pro Ser Pro Pro Pro Gly Ile Pro Gly Gln 
        755                 760                 765             


Pro Leu Pro Ser Pro Thr Arg Leu His Leu Gly Gly Gly Arg Asn Ser 
    770                 775                 780                 


Asn Ala Asn Gly Tyr Val Arg Leu Gln Leu Gly Gly Glu Asp Arg Gly 
785                 790                 795                 800 


Gly Leu Gly His Pro Leu Pro Glu Leu Ala Asp Glu Leu Arg Arg Lys 
                805                 810                 815     


Leu Gln Gln Arg Gln Pro Leu Pro Asp Ser Asn Pro Glu Glu Ser Ser 
            820                 825                 830         


Val 
    


<210>  7937
<211>  1054
<212>  DNA
<213>  Homosapiens

<400>  7937
cagccccgcc atgccggggc ctaccactgc ttttcagagg agcagggggc gcggctggct     60

gctgaaggct accttgtggc tgtcgtggca ggcccgtcgg tgaccttgga ggcccgggcc    120

cccctggaaa acctggggct ggtgtggctg gcggtggtgg ccctgggggc tgtgtgcctg    180

gtgctgctgc tgctggtgct gtcattgcgc cggcggctgc gggaagagct ggagaaaggg    240

gccaaggcta ctgagaggac cttggtgtac cccctggagc tgcccaagga gcccaccagt    300

ccccccttcc ggccctgtcc tgaaccagat gagaaacttt gggatcctgt cggttactac    360

tattcagatg gctcccttaa gatagtacct gggcatgccc ggtgccagcc cggtgggggg    420

cccccttcgc cacctccagg catcccaggc cagcctctgc cttctccaac tcggcttcac    480

ctggggggtg ggcggaactc aaatgccaat ggttacgtgc gcttacaact aggaggggag    540

gaccggggag ggctcgggca ccccctgcct gagctcgcgg atgaactgag acgcaaactg    600

cagcaacgcc agccactgcc cgactccaac cccgaggagt catcagtatg aggggaaccc    660

ccaccgcgtc ggcgggaagc gtgggaggtg tagctcctac ttttgcacag gcaccagcta    720

cctcagggac atggcacggg cacctgctct gtctgggaca gatactgccc agcacccacc    780

cggccatgag gacctgctct gctcagcacg ggcactgcca ttggccccgg ggttcagtgg    840

tattttatac ttgccttctt cctgtacagg gctgggaaag gctgtgtgag gggagagaag    900

ggagagggtg ggcctgctgt ggacaatggc atactctctt ccagccctag gaggagggct    960

cctaacagtg taacttattg tgtccccgcg tatttatttg ttgtaaatat ttgagtattt   1020

ttatattgac aaataaaatg gagaaaatga aacg                               1054


<210>  7938
<211>  100
<212>  PRT
<213>  Homosapiens

<400>  7938

Met Arg Gly Thr Pro Thr Ala Ser Ala Gly Ser Val Gly Gly Val Ala 
1               5                   10                  15      


Pro Thr Phe Ala Gln Ala Pro Ala Thr Ser Gly Thr Trp His Gly His 
            20                  25                  30          


Leu Leu Cys Leu Gly Gln Ile Leu Pro Ser Thr His Pro Ala Met Arg 
        35                  40                  45              


Thr Cys Ser Ala Gln His Gly His Cys His Trp Pro Arg Gly Ser Val 
    50                  55                  60                  


Val Phe Tyr Thr Cys Leu Leu Pro Val Gln Gly Trp Glu Arg Leu Cys 
65                  70                  75                  80  


Glu Gly Arg Glu Gly Arg Gly Trp Ala Cys Cys Gly Gln Trp His Thr 
                85                  90                  95      


Leu Phe Gln Pro 
            100 


<210>  7939
<211>  615
<212>  DNA
<213>  Homosapiens

<400>  7939
tatcagttgt actttcattt agaagtatga atcatgagca agtagtcatg caggaaattg     60

tatcctctgc ccacccaccc acagaaaggg ccagtgctgg aatggacaga atacagcagg    120

aagtgcatga aggtggaaaa ggggagggag ctgggagctt atctccgaga gcgtttggga    180

ggataggcgc gtggagtctg ttagctggag gcttctacat tcctgggcct ccagaaccca    240

aacgcctgcc gctgccctgc cagtgaaacc aaaccggttg ccttttgaaa ctttccactg    300

aggccacctt ggagtcagag ccagcgagct caggtctctc ctggtaacct tcacacctag    360

aggtgggggg atgggggagc agtattgaag gtgaggaaaa acagcatgaa atggagcatt    420

gtcaggatag atggtgactc tgtggaaaaa cagaatcggg agtcccaaga cctgatttaa    480

aaatctgaac tttccagtct gagcaatata gcgagaccct gtcccgtgta tgatggtgtg    540

cacctgtagt cttgggaggc tcacgtggga ggaccgctga gtagctggga cttacagatg    600

catgccacca cgccc                                                     615


<210>  7940
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  7940

Met Asn His Glu Gln Val Val Met Gln Glu Ile Val Ser Ser Ala His 
1               5                   10                  15      


Pro Pro Thr Glu Arg Ala Ser Ala Gly Met Asp Arg Ile Gln Gln Glu 
            20                  25                  30          


Val His Glu Gly Gly Lys Gly Glu Gly Ala Gly Ser Leu Ser Pro Arg 
        35                  40                  45              


Ala Phe Gly Arg Ile Gly Ala Trp Ser Leu Leu Ala Gly Gly Phe Tyr 
    50                  55                  60                  


Ile Pro Gly Pro Pro Glu Pro Lys Arg Leu Pro Leu Pro Cys Gln 
65                  70                  75                  


<210>  7941
<211>  864
<212>  DNA
<213>  Homosapiens

<400>  7941
aaagagcggg aaggggagtg gaaggcaggg gctgaagaca caggccaggc ggaatgaaga     60

tgatggtggt cttgctcatg ctgtcctcgc tcagccggct cctgggcctc atgaggccat    120

catctctcag gcaatacctg gactctgtgc ccttgccacc ctgccaggag caacagccaa    180

aggctagtgc cgagctagac cacaaggcct gctacctgtg ccacagcttg ctgatgctgg    240

ccggggtagt tgttagctgc caggacatca ctccagacca gtggggcgag ctgcagctgc    300

tgtgcatgca gttggaccgc cacatcagca cgcagatccg ggagagcccc caggccatgc    360

accgcaccat gctcaaggac ctggctaccc agacctacat ccgttggcag gagctgctga    420

cccactgcca gccccaggcc cagtatttca gcccctggaa agacatctaa agggacaggg    480

tcagggcagc ccagggctcc tggcttcagc aggaagtgaa caggctcagg gaactggagg    540

aagcgaagca tcaaggccag aggaggccac atgctgacca gcctgatgag gcaagagcct    600

gcccctgcca ccgccccgac ccctctcctc tctgcaagag cctgcctctg ccaccgcccc    660

gaccccctct cctctcagca agggatgggc ctctctgcct cgcccacccc tcagccctcc    720

tcccagccat ctcctcttcc ctaaggcctc tgtctccata gctctggttt ccctgggcct    780

cagtcctccc caccctcctt cctctgtctc cctgtcacta atgtgaggtt tctttgtgca    840

cattaaagtc ttctttcagc atca                                           864


<210>  7942
<211>  138
<212>  PRT
<213>  Homosapiens

<400>  7942

Met Lys Met Met Val Val Leu Leu Met Leu Ser Ser Leu Ser Arg Leu 
1               5                   10                  15      


Leu Gly Leu Met Arg Pro Ser Ser Leu Arg Gln Tyr Leu Asp Ser Val 
            20                  25                  30          


Pro Leu Pro Pro Cys Gln Glu Gln Gln Pro Lys Ala Ser Ala Glu Leu 
        35                  40                  45              


Asp His Lys Ala Cys Tyr Leu Cys His Ser Leu Leu Met Leu Ala Gly 
    50                  55                  60                  


Val Val Val Ser Cys Gln Asp Ile Thr Pro Asp Gln Trp Gly Glu Leu 
65                  70                  75                  80  


Gln Leu Leu Cys Met Gln Leu Asp Arg His Ile Ser Thr Gln Ile Arg 
                85                  90                  95      


Glu Ser Pro Gln Ala Met His Arg Thr Met Leu Lys Asp Leu Ala Thr 
            100                 105                 110         


Gln Thr Tyr Ile Arg Trp Gln Glu Leu Leu Thr His Cys Gln Pro Gln 
        115                 120                 125             


Ala Gln Tyr Phe Ser Pro Trp Lys Asp Ile 
    130                 135             


<210>  7943
<211>  1005
<212>  DNA
<213>  Homosapiens

<400>  7943
gcacaggggt ttagaattga ctggtgtagg agcagaggac ctggggctgg atctgggcac     60

agcaatttgc agggcactgc tgggcaggag tccctgatgg ccaagctgct gggctctgta    120

tctcccacaa gctgcagcgg aggccccatg gagcaggagc agaagcacac gttggagaac    180

tgaacttgaa ggacaggact tacagcattg aggtcacaca gctgtcctcg ctcagccggc    240

tcctgggcct catgaggcca tcatctctca ggcaatacct ggactctgtg cccttgccac    300

cctgccagga gcaacagcca aaggctagtg ccgagctaga ccacaaggcc tgctacctgt    360

gccacagctt gctgatgctg gccggggtag ttgttagctg ccaggacatc actccagacc    420

agtggggcga gctgcagctg ctgtgcatgc agttggaccg ccacatcagc acgcagatcc    480

gggagagccc ccaggccatg caccgcacca tgctcaagga cctggctacc cagacctaca    540

tccgttggca ggagctgctg acccactgcc agccccaggc ccagtatttc agcccctgga    600

aagacatcta aagggacagg gtcagggcag cccagggctc ctggcttcag caggaagtga    660

acaggctcag ggaactggag gaagcgaagc atcaaggcca gaggaggcca catgctgacc    720

agcctgatga ggcaagagcc tgcccctgcc accgccccga cccctctcct ctctgcaaga    780

gcctgcctct gccaccgccc cgaccccctc tcctctcagc aagggatggg cctctctgcc    840

tcgcccaccc ctcagccctc ctcccagcca tctcctcttc cctaaggcct ctgtctccat    900

agctctggtt tccctgggcc tcagtcctcc ccaccctcct tcctctgtct ccctgtcact    960

aatgtgaggt ttctttgtgc acattaaagt cttctttcag catca                   1005


<210>  7944
<211>  119
<212>  PRT
<213>  Homosapiens

<400>  7944

Met Arg Pro Ser Ser Leu Arg Gln Tyr Leu Asp Ser Val Pro Leu Pro 
1               5                   10                  15      


Pro Cys Gln Glu Gln Gln Pro Lys Ala Ser Ala Glu Leu Asp His Lys 
            20                  25                  30          


Ala Cys Tyr Leu Cys His Ser Leu Leu Met Leu Ala Gly Val Val Val 
        35                  40                  45              


Ser Cys Gln Asp Ile Thr Pro Asp Gln Trp Gly Glu Leu Gln Leu Leu 
    50                  55                  60                  


Cys Met Gln Leu Asp Arg His Ile Ser Thr Gln Ile Arg Glu Ser Pro 
65                  70                  75                  80  


Gln Ala Met His Arg Thr Met Leu Lys Asp Leu Ala Thr Gln Thr Tyr 
                85                  90                  95      


Ile Arg Trp Gln Glu Leu Leu Thr His Cys Gln Pro Gln Ala Gln Tyr 
            100                 105                 110         


Phe Ser Pro Trp Lys Asp Ile 
        115                 


<210>  7945
<211>  1952
<212>  DNA
<213>  Homosapiens

<400>  7945
ggacccgaag aggggcctgg ccttgccaga gaagctgttc tggaacacgt caggcctgag     60

ccagcaggct gcggccccag agttttcctg ggggggctca ggaagctact tcaacaacct    120

ggactactta ctgcaggaga agagggaaca ggccctggag caggagcgag agaggctgct    180

tctgcaggag tgtctcaatc tcaactcctt ggatcttgat gaagaggaag tgccactcac    240

acccgagcac aggatgctgg tggaaaagta ctcagtgtcc ctgcagacca tcccgccggt    300

ccatccaggt gagactgtgt ttctgcccag gtgtcacccc ctgccatgca tcctggactc    360

ctcactcctg aagccacgca gccacctgga agggctgttc ctcagctccc cgccagccca    420

acagctctcc ttcctgcgca gtggcctcct gaacatcctc tacctgcaca tgcctgactg    480

cccggtatcc ctgctccagt ggctgttcca gctgctgaca tggcctccag aaacatcttt    540

gggagccttt ggtcttctgt gggatctcat tgtggatgga atcttccttc agcctgatga    600

agacaagcac ctgtggtgcc cctcactgca agaagtcagg gaggcattcc acagcctggg    660

tgcccacagt cctgccctgt accctctggg gcccttttgg cacggtggca gggtgcttcc    720

aggcgaggct ggcctgaatg agaatgagga gcaggacgct ccccaagaga ttgccttgga    780

catcagcctg ggccacatct acaagtttct ggcgctgtgt gcccaggccc agccgggggc    840

ctacactgat gagaacctca tgggactgat tgagctgctg tgccgcacca gcctggacgt    900

ggggctccgc ctgctgccca aagttgacct ccagcagctt ctcctcttgc tcctggagaa    960

catccgggag tggccaggga agctccagga actgtgctgc accctgagct gggtgtctga   1020

ccaccaccac aacctgctgg ccctcgtgca gttcttccca gacatgacct cccggagcag   1080

gcggcttcga agccagctca gccttgtggt cattgctcga atgctgggcc agcaggagat   1140

gctccctctc tggcaagaga agacccagct gtcctcgctc agccggctcc tgggcctcat   1200

gaggccatca tctctcaggc aatacctgga ctctgtgccc ttgccaccct gccaggagca   1260

acagccaaag gctagtgccg agctagacca caaggcctgc tacctgtgcc acagcttgct   1320

gatgctggcc ggggtagttg ttagctgcca ggacatcact ccagaccagt ggggcgagct   1380

gcagctgctg tgcatgcagt tggaccgcca catcagcacg cagatccggg agagccccca   1440

ggccatgcac cgcaccatgc tcaaggacct ggctacccag acctacatcc gttggcagga   1500

gctgctgacc cactgccagc cccaggccca gtatttcagc ccctggaaag acatctaaag   1560

ggacagggtc agggcagccc agggctcctg gcttcagcag gaagtgaaca ggctcaggga   1620

actggaggaa gcgaagcatc aaggccagag gaggccacat gctgaccagc ctgatgaggc   1680

aagagcctgc ccctgccacc gccccgaccc ctctcctctc tgcaagagcc tgcctctgcc   1740

accgccccga ccccctctcc tctcagcaag ggatgggcct ctctgcctcg cccacccctc   1800

agccctcctc ccagccatct cctcttccct aaggcctctg tctccatagc tctggtttcc   1860

ctgggcctca gtcctcccca ccctccttcc tctgtctccc tgtcactaat gtgaggtttc   1920

tttgtgcaca ttaaagtctt ctttcagcat ca                                 1952


<210>  7946
<211>  434
<212>  PRT
<213>  Homosapiens

<400>  7946

Met Leu Val Glu Lys Tyr Ser Val Ser Leu Gln Thr Ile Pro Pro Val 
1               5                   10                  15      


His Pro Gly Glu Thr Val Phe Leu Pro Arg Cys His Pro Leu Pro Cys 
            20                  25                  30          


Ile Leu Asp Ser Ser Leu Leu Lys Pro Arg Ser His Leu Glu Gly Leu 
        35                  40                  45              


Phe Leu Ser Ser Pro Pro Ala Gln Gln Leu Ser Phe Leu Arg Ser Gly 
    50                  55                  60                  


Leu Leu Asn Ile Leu Tyr Leu His Met Pro Asp Cys Pro Val Ser Leu 
65                  70                  75                  80  


Leu Gln Trp Leu Phe Gln Leu Leu Thr Trp Pro Pro Glu Thr Ser Leu 
                85                  90                  95      


Gly Ala Phe Gly Leu Leu Trp Asp Leu Ile Val Asp Gly Ile Phe Leu 
            100                 105                 110         


Gln Pro Asp Glu Asp Lys His Leu Trp Cys Pro Ser Leu Gln Glu Val 
        115                 120                 125             


Arg Glu Ala Phe His Ser Leu Gly Ala His Ser Pro Ala Leu Tyr Pro 
    130                 135                 140                 


Leu Gly Pro Phe Trp His Gly Gly Arg Val Leu Pro Gly Glu Ala Gly 
145                 150                 155                 160 


Leu Asn Glu Asn Glu Glu Gln Asp Ala Pro Gln Glu Ile Ala Leu Asp 
                165                 170                 175     


Ile Ser Leu Gly His Ile Tyr Lys Phe Leu Ala Leu Cys Ala Gln Ala 
            180                 185                 190         


Gln Pro Gly Ala Tyr Thr Asp Glu Asn Leu Met Gly Leu Ile Glu Leu 
        195                 200                 205             


Leu Cys Arg Thr Ser Leu Asp Val Gly Leu Arg Leu Leu Pro Lys Val 
    210                 215                 220                 


Asp Leu Gln Gln Leu Leu Leu Leu Leu Leu Glu Asn Ile Arg Glu Trp 
225                 230                 235                 240 


Pro Gly Lys Leu Gln Glu Leu Cys Cys Thr Leu Ser Trp Val Ser Asp 
                245                 250                 255     


His His His Asn Leu Leu Ala Leu Val Gln Phe Phe Pro Asp Met Thr 
            260                 265                 270         


Ser Arg Ser Arg Arg Leu Arg Ser Gln Leu Ser Leu Val Val Ile Ala 
        275                 280                 285             


Arg Met Leu Gly Gln Gln Glu Met Leu Pro Leu Trp Gln Glu Lys Thr 
    290                 295                 300                 


Gln Leu Ser Ser Leu Ser Arg Leu Leu Gly Leu Met Arg Pro Ser Ser 
305                 310                 315                 320 


Leu Arg Gln Tyr Leu Asp Ser Val Pro Leu Pro Pro Cys Gln Glu Gln 
                325                 330                 335     


Gln Pro Lys Ala Ser Ala Glu Leu Asp His Lys Ala Cys Tyr Leu Cys 
            340                 345                 350         


His Ser Leu Leu Met Leu Ala Gly Val Val Val Ser Cys Gln Asp Ile 
        355                 360                 365             


Thr Pro Asp Gln Trp Gly Glu Leu Gln Leu Leu Cys Met Gln Leu Asp 
    370                 375                 380                 


Arg His Ile Ser Thr Gln Ile Arg Glu Ser Pro Gln Ala Met His Arg 
385                 390                 395                 400 


Thr Met Leu Lys Asp Leu Ala Thr Gln Thr Tyr Ile Arg Trp Gln Glu 
                405                 410                 415     


Leu Leu Thr His Cys Gln Pro Gln Ala Gln Tyr Phe Ser Pro Trp Lys 
            420                 425                 430         


Asp Ile 
        


<210>  7947
<211>  908
<212>  DNA
<213>  Homosapiens

<400>  7947
tgactgcctc cttccagacc ttctggcctc acccgcccac agtgagagct ctctgtgaca     60

ctctgagctc cgaagaatcc aacctgcccg agggtgggca ggattcagcc atgagtgaaa    120

gagaactggg ggaggaagct tggagctgcg gcaggagctc gagggagatg tgggtggaga    180

cagaacggct gttttaaggt accatataat actccgtagc acgggcagaa ctgaatcgat    240

ggtggggcac tgaggcaatt tccagttctt cactatcatg acattgctat gccaaacatc    300

cttgtcaatg aatctttgcc atctagttcc ccagaaaacg atctagcttt ttgaagggtg    360

tgcacatttt aaagtcattt gcttgatttt gccaaactgg cctccagagg gactactgac    420

cgcatctcat gagcagggaa gcatatgcct gtttcctcac atcctgccaa cactgggcag    480

cactgtcctt tcggattgat tctggtctgc caggcaagga actctacgtc attgtcaggg    540

ctggtttcgt gagccgtttt acgcaggctt tgtccattcc tccatctgac caggcagcct    600

gcgggagctg gcttcatctg accttctgct ttgaagcagc gcacacagga tgtttaatga    660

atagccgcag gcagtgaagg aagaggatcc ccagagcctg ggacatcagc tttcagtaga    720

gtgcaagcag ttgcaggagc cctgaacaga agtggggatg gcatgctgct cttcccaaag    780

ctgcctgagc tgccccaatg gcgccacctc ccaaggtgga tgttcctcca agaacctcct    840

cttccccttg gctctgtttc aggtggtctg ccttagtatt cactttcatt tttcatggtt    900

aggcccag                                                             908


<210>  7948
<211>  82
<212>  PRT
<213>  Homosapiens

<400>  7948

Met Ser Arg Glu Ala Tyr Ala Cys Phe Leu Thr Ser Cys Gln His Trp 
1               5                   10                  15      


Ala Ala Leu Ser Phe Arg Ile Asp Ser Gly Leu Pro Gly Lys Glu Leu 
            20                  25                  30          


Tyr Val Ile Val Arg Ala Gly Phe Val Ser Arg Phe Thr Gln Ala Leu 
        35                  40                  45              


Ser Ile Pro Pro Ser Asp Gln Ala Ala Cys Gly Ser Trp Leu His Leu 
    50                  55                  60                  


Thr Phe Cys Phe Glu Ala Ala His Thr Gly Cys Leu Met Asn Ser Arg 
65                  70                  75                  80  


Arg Gln 
        


<210>  7949
<211>  2259
<212>  DNA
<213>  Homosapiens

<400>  7949
gtctgagggg ttctggactg tggtcgccct gctacattag gagactacag tggcacacac     60

actagggaaa tactatgcag ctgtgaaaag agtgaggttt attgtgtgta tgtgtgagaa    120

aaacaaccac aaacaccatg ccctggatgg agcaaatgag aaactggctg gacgaggtgg    180

atgagggggc ctagggacca gcctaagaat ttgcacctgg ccctgcaggc aatggggagc    240

atggtaaggc agagacgtga tcatcacagg aacccccagg catctacaga gcaggcagac    300

tttggagaag aggaagaaat gcctctgcca ccctccagag agaggatgaa acctgccctc    360

tcccaactgt gcacaggctg cctctctgcc agccagattc ccaggaaaga cagaaagaga    420

tgggactgcc tgctcagcac tgaagcggag cccaggacaa ctgaagggcc gacctgactt    480

ggtgtaggag gaggctacag aactatgtga actctaagaa tgggggacac atggaggggg    540

gctccttggg gactggctcc cacatgctac cgttcaggtg aggcctcgag ctttagtttt    600

ccaggacttg gaaaccagaa aatcacactt ccaatccccc caaagtccgt gagttctccc    660

tgggtccgtt cgacaagggt gagcctgcat acactgcaaa gtgcaccacg tggtagctga    720

cacgggctgg ctcacaagcc agcaagtatg ggggaaatca gaacaaaaca tccctgaaaa    780

ccccctccaa aggtgtcacc ctgagctgat gtgctgtctg ctgataagac ctgcatggcc    840

agtttccccg agtgacggac ccaatctggc tgagcaccag atgatgttag agaccagggc    900

tggggaaaga aaaatccccc cctttaaaga tcaagccaca cgcagggtgg tgagatgctt    960

acggtgaggg ggacctcggt ggggctttgt ggatggcagt ctcatcaccc tttccacaag   1020

cctccctccc aggcacgcgc tcacaggacg agagcctggg cgggatcacc ttcatcgtat   1080

ggccgaatgt acattgttga tttcaagtat gttaagtgag cttatgatga gggtcccctc   1140

tgctgtctca cccacttctc cactcttaag aaacggctta aggttcctgc taacagtggt   1200

aagtgaagat attgatgaca accacactgc tgatgacagc aggctccagg cagccccctg   1260

gcacagggga ggaagagcac tgtcctacag ctcctgtgaa gtctctgctc ttctctgctt   1320

ggcactggcg ctgggctcag aggggaagga ggagagatct gtctccgagg taccaggaag   1380

ttggtgccga caaaccaaac ttggtggggg agtggaaact gtggctgggc tcagtccttc   1440

ttccagattt cagcatttat tagggcccta actgaatggg taaggctggc atttgcacat   1500

ctgggcgcag gctgggcctg cgccagtacg tgaggggaag ctctggttcg taccagcctt   1560

gagcgtgcaa cacgcgcagc cataggtggg tgtgctttca ggtttctcag cacggggcac   1620

tcagagtcga ctacaaacat ctgcagaaga gagacgctgc caaggggaga aggaacattg   1680

aaggtgtgag gtggttacat gtgttttttg agctgcagag aggagtgtgg ctgtggggag   1740

agccctgtcc tccttggaaa gaaatgtcag ccttcccaag tgaatgcctg gctggtcaga   1800

gttccagaac tttgtgagcc catggactaa tgggcaacat aatgggggtc ctctaatcct   1860

cgcttttcag aggaatcact tgactaaact gctggcatct gtggctgctg ttctgagctg   1920

cagcatcagc tgatccccga aactccacca ctgctgccag caaggggcca cagcccggga   1980

attcaacggc ctatctatta tccctgctcc cctcctgggc ttagcaggtt agagtgagct   2040

gatggtccca ccattggact cttatgagca aagcagcttc actggtccca cgcctggctc   2100

cagggtctgt ggccagcacc taggaactgg gtttctgtct cggagacacc gttcaatact   2160

cattaacctt acaaggggca tgtcactggc ctctacccag gtctccgcat cttcttcccc   2220

caaaagttga aaaaataata aagttaccat ctgcatggc                          2259


<210>  7950
<211>  98
<212>  PRT
<213>  Homosapiens

<400>  7950

Met Arg Gly Pro Arg Asp Gln Pro Lys Asn Leu His Leu Ala Leu Gln 
1               5                   10                  15      


Ala Met Gly Ser Met Val Arg Gln Arg Arg Asp His His Arg Asn Pro 
            20                  25                  30          


Gln Ala Ser Thr Glu Gln Ala Asp Phe Gly Glu Glu Glu Glu Met Pro 
        35                  40                  45              


Leu Pro Pro Ser Arg Glu Arg Met Lys Pro Ala Leu Ser Gln Leu Cys 
    50                  55                  60                  


Thr Gly Cys Leu Ser Ala Ser Gln Ile Pro Arg Lys Asp Arg Lys Arg 
65                  70                  75                  80  


Trp Asp Cys Leu Leu Ser Thr Glu Ala Glu Pro Arg Thr Thr Glu Gly 
                85                  90                  95      


Pro Thr 
        


<210>  7951
<211>  668
<212>  DNA
<213>  Homosapiens

<400>  7951
ggcgagctcc ccagctggcg gcggcggcgg ctgtgagctg gccgcttggt ttggagtcgg     60

aactcaatcc ccagaactgg atctttaggt tccacgttgg cggccctgga tctagggacg    120

caactcttgg ggtcctccca ctgcgccgcc tggggagcct gctcctgctt cctttcccgg    180

ctagctggcc ccgtcctctg aggccgtgcg aattcccgcc accctccctc accccggagc    240

cctgcccttc ccgccctatg tggccaaggc ttccaggtgc gggcctcgct ccacaactca    300

ggaggcagga tcagcggctc cattttacag gacagatgtc ccacggcttg cagatggctg    360

ggccccagga gacggtgcta gcccttcctc tgagagaagg ggtgcaggct gccgccaccg    420

tgcccatcct cctgtacaac ctggaggatg gcttgtcaga ccatcccctg gaccaggggc    480

cccgctgccc tgcccggcgg ccctgcagcc ctgcctcggc tccagctccc acatcgccaa    540

agaagcccaa gatacaggca cctggggaaa cgtttcccac tgactggagc cccccgcccg    600

tggaattcct caacccgagg gtgctgcagg ccagtcggga ggccccggcc cagaggtggg    660

tgggtgtg                                                             668


<210>  7952
<211>  136
<212>  PRT
<213>  Homosapiens

<400>  7952

Met Trp Pro Arg Leu Pro Gly Ala Gly Leu Ala Pro Gln Leu Arg Arg 
1               5                   10                  15      


Gln Asp Gln Arg Leu His Phe Thr Gly Gln Met Ser His Gly Leu Gln 
            20                  25                  30          


Met Ala Gly Pro Gln Glu Thr Val Leu Ala Leu Pro Leu Arg Glu Gly 
        35                  40                  45              


Val Gln Ala Ala Ala Thr Val Pro Ile Leu Leu Tyr Asn Leu Glu Asp 
    50                  55                  60                  


Gly Leu Ser Asp His Pro Leu Asp Gln Gly Pro Arg Cys Pro Ala Arg 
65                  70                  75                  80  


Arg Pro Cys Ser Pro Ala Ser Ala Pro Ala Pro Thr Ser Pro Lys Lys 
                85                  90                  95      


Pro Lys Ile Gln Ala Pro Gly Glu Thr Phe Pro Thr Asp Trp Ser Pro 
            100                 105                 110         


Pro Pro Val Glu Phe Leu Asn Pro Arg Val Leu Gln Ala Ser Arg Glu 
        115                 120                 125             


Ala Pro Ala Gln Arg Trp Val Gly 
    130                 135     


<210>  7953
<211>  947
<212>  DNA
<213>  Homosapiens

<400>  7953
atggaccctc cgcccccagc ctgtgcagtg cgggggctgc tggcaggcag agtgccgccc     60

caggggccct gggagctgca gggcatattg ctgctgagcc agaatgagct gtaccgccag    120

atcctgctgc tgatgcacct gctgccgcaa gacctgctgc tgctaaagcc ctgccagtct    180

tcctactgct actgtcagga ggtgctggac aggctcatcc aatgcgggct cctggttgct    240

gaggagcttg tcagagaaca atggctccgg gtccggccag cctgtgacac agggcaacgg    300

cgactgagca gaaagctgct gtggaaaccg aggaggtggt ggggagctgc actcaccccg    360

gcctgtcccc tccagctcag ccagcagtca cactgcccag atttctttct tttcctctgc    420

cgcctgctca gcccgctgct caaggccttt gcacaggctg ccgccttcct ccgccagggc    480

cagctgcccg atactgagtc gggctacaca gaccagctgt tccagttcct gcaggccacc    540

gcccaggaag aagggatctt cgagtgtgcg gacccaaagc ttgccatcag tgctatctgg    600

accttcagag acctaggggt tctgcagcag acgccgagcc ctgcaggccc caggctccac    660

ctatccccta cttttgccag ccaggacaat caggaaaaac tagaacagtt catccggcag    720

ttcatttgta gctagaactg tgaggaggag cctgtgctga gacttctcag ccccagaaca    780

cagctgtgtc ctagagccag aagatggaga ggaggctgca aacccttagc tgctctataa    840

atataatcat tgaggcttga ttgtcccttg ccatctcttg ctttttccct cctttgatgt    900

gataaacaag gggacgagac gagttgtctt ttccccagcc cagcagc                  947


<210>  7954
<211>  244
<212>  PRT
<213>  Homosapiens

<400>  7954

Met Asp Pro Pro Pro Pro Ala Cys Ala Val Arg Gly Leu Leu Ala Gly 
1               5                   10                  15      


Arg Val Pro Pro Gln Gly Pro Trp Glu Leu Gln Gly Ile Leu Leu Leu 
            20                  25                  30          


Ser Gln Asn Glu Leu Tyr Arg Gln Ile Leu Leu Leu Met His Leu Leu 
        35                  40                  45              


Pro Gln Asp Leu Leu Leu Leu Lys Pro Cys Gln Ser Ser Tyr Cys Tyr 
    50                  55                  60                  


Cys Gln Glu Val Leu Asp Arg Leu Ile Gln Cys Gly Leu Leu Val Ala 
65                  70                  75                  80  


Glu Glu Leu Val Arg Glu Gln Trp Leu Arg Val Arg Pro Ala Cys Asp 
                85                  90                  95      


Thr Gly Gln Arg Arg Leu Ser Arg Lys Leu Leu Trp Lys Pro Arg Arg 
            100                 105                 110         


Trp Trp Gly Ala Ala Leu Thr Pro Ala Cys Pro Leu Gln Leu Ser Gln 
        115                 120                 125             


Gln Ser His Cys Pro Asp Phe Phe Leu Phe Leu Cys Arg Leu Leu Ser 
    130                 135                 140                 


Pro Leu Leu Lys Ala Phe Ala Gln Ala Ala Ala Phe Leu Arg Gln Gly 
145                 150                 155                 160 


Gln Leu Pro Asp Thr Glu Ser Gly Tyr Thr Asp Gln Leu Phe Gln Phe 
                165                 170                 175     


Leu Gln Ala Thr Ala Gln Glu Glu Gly Ile Phe Glu Cys Ala Asp Pro 
            180                 185                 190         


Lys Leu Ala Ile Ser Ala Ile Trp Thr Phe Arg Asp Leu Gly Val Leu 
        195                 200                 205             


Gln Gln Thr Pro Ser Pro Ala Gly Pro Arg Leu His Leu Ser Pro Thr 
    210                 215                 220                 


Phe Ala Ser Gln Asp Asn Gln Glu Lys Leu Glu Gln Phe Ile Arg Gln 
225                 230                 235                 240 


Phe Ile Cys Ser 
                


<210>  7955
<211>  1017
<212>  DNA
<213>  Homosapiens

<400>  7955
ctgtgttacc caggctggtt ttgaactcct gagcttaatc agttctcacc tgttttgccc     60

tcccaaagtg ctatgattac aggtgtgagc caccacgctt ggccctgccc gggagtcatt    120

tttgtatcta caggtatctt cctatgctgt agacagatgc cctttcttga ggcaaaaacc    180

ctagccattt ttctcttctc cttcagagtc tggaacatcc tctcaactca ttcaagtgac    240

tactgcctgg tgctcttggt ggggatgcag ggaggcctga gaaggccagt gtctatacag    300

aaagttctaa catagtgcac tgagtcaatg tgggcacttt aaagcccttt cacctgccaa    360

gtcacgaagc gcccctacag ttgtgtttgt aaaacactgg ggggtttgag ggggaaaagg    420

gataactcca aggttccatc tttgcatttc agatccacac aacttaaaga tctgctgccg    480

agtgaatggg gaagtcgtcc agagcagcaa caccaaccag atggtattca agacagagga    540

cctgatagcc tgggtctccc agtgagtgac aagggctgtc ctgccagccc cgctccacct    600

gccacacatg tggaggctga cctgagccct ccacctttgg ctgtggccac tcagccagcc    660

cctggtctca ctgggtcctt ttgctttgct ccaggtttgt taccttttac ccaggggatg    720

tcatcctaac tgggaccccc ccaggtgtcg gtgtattcag gaaacctcct gtctttctca    780

agaaggggga tgaagtccag tgtgagattg aagaactagg tgtcatcatc aacaaggtgg    840

tgtgatggct cctgcacagg cccgacatag gatgagggca tctgctccca ctcagcctag    900

cccagggaaa ggcccagtgg caggtgtggg caggtgccag ccctgcaagc cgcctcttct    960

cggtagaagg gagaaggaca gagctctctt caataaatgc gtcgggtcaa agcagca      1017


<210>  7956
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  7956

Met Ile Thr Gly Val Ser His His Ala Trp Pro Cys Pro Gly Val Ile 
1               5                   10                  15      


Phe Val Ser Thr Gly Ile Phe Leu Cys Cys Arg Gln Met Pro Phe Leu 
            20                  25                  30          


Glu Ala Lys Thr Leu Ala Ile Phe Leu Phe Ser Phe Arg Val Trp Asn 
        35                  40                  45              


Ile Leu Ser Thr His Ser Ser Asp Tyr Cys Leu Val Leu Leu Val Gly 
    50                  55                  60                  


Met Gln Gly Gly Leu Arg Arg Pro Val Ser Ile Gln Lys Val Leu Thr 
65                  70                  75                  80  


<210>  7957
<211>  1305
<212>  DNA
<213>  Homosapiens

<400>  7957
acaggacgcg cccgcttctc gctggagtgc gcaccgagcg gcagtgactt cgccgctgct     60

gtagttcccc ggctggatgc ggtgactggt gccagtgctc aggcgcccgc tgcccttgac    120

ctcccgcccc gcgagcccta actcagcgca ggaggaccgg ctgccgccgc cgccgccgcc    180

aggctctgat gctggtgtct ggtagaagaa gattactcac agctctgctg caggctcaga    240

agtggccctt tcaaccctcc agagacatga gactagtgca gttccgggca ccccacctgg    300

tggggcctca cttgggcctg gagacaggga atggtggagg ggttatcaac ctcaatgcct    360

ttgaccccac actcccaaag acgatgacgc agttcctaga gcagggagag gccaccctct    420

cagtggcaag aagagccttg gctgcccagt tgccagtcct accatggtcg gaggtaacct    480

tcctggctcc agtcacatgg ccagataagg tggtgtgtgt gggcatgaat tatgtggacc    540

actgcaaaga acagaacgtg cccgtgccca aggagcccat catcttcagc aagtttgcca    600

gctccatcgt ggggccctat gatgaggtgg tcctcccacc acagagccag gaggtagatt    660

gggaagtgga gctggccgtg gtcattggaa agaaaggcaa gcacatcaag gccacagatg    720

ccatggccca cgtggccggc ttcactgtgg ctcatgacgt gagtgctcgt gactggctaa    780

caagacgcaa tgggaaacag tggctgctgg gaaaaacctt cgacaccttc tgccctctgg    840

gccctgcctt ggtgaccaag gacagtgtag cagatccaca caacttaaag atctgctgcc    900

gagtgaatgg ggaagtcgtc cagagcagca acaccaacca gatggtattc aagacagagg    960

acctgatagc ctgggtctcc cagtttgtta ccttttaccc aggggatgtc atcctaactg   1020

ggaccccccc aggtgtcggt gtattcagga aacctcctgt ctttctcaag aagggggatg   1080

aagtccagtg tgagattgaa gaactaggtg tcatcatcaa caaggtggtg tgatggctcc   1140

tgcacaggcc cgacatagga tgagggcatc tgctcccact cagcctagcc cagggaaagg   1200

cccagtggca ggtgtgggca ggtgccagcc ctgcaagccg cctcttctcg gtagaaggga   1260

gaaggacaga gctctcttca ataaatgcgt cgggtcaaag cagca                   1305


<210>  7958
<211>  314
<212>  PRT
<213>  Homosapiens

<400>  7958

Met Leu Val Ser Gly Arg Arg Arg Leu Leu Thr Ala Leu Leu Gln Ala 
1               5                   10                  15      


Gln Lys Trp Pro Phe Gln Pro Ser Arg Asp Met Arg Leu Val Gln Phe 
            20                  25                  30          


Arg Ala Pro His Leu Val Gly Pro His Leu Gly Leu Glu Thr Gly Asn 
        35                  40                  45              


Gly Gly Gly Val Ile Asn Leu Asn Ala Phe Asp Pro Thr Leu Pro Lys 
    50                  55                  60                  


Thr Met Thr Gln Phe Leu Glu Gln Gly Glu Ala Thr Leu Ser Val Ala 
65                  70                  75                  80  


Arg Arg Ala Leu Ala Ala Gln Leu Pro Val Leu Pro Trp Ser Glu Val 
                85                  90                  95      


Thr Phe Leu Ala Pro Val Thr Trp Pro Asp Lys Val Val Cys Val Gly 
            100                 105                 110         


Met Asn Tyr Val Asp His Cys Lys Glu Gln Asn Val Pro Val Pro Lys 
        115                 120                 125             


Glu Pro Ile Ile Phe Ser Lys Phe Ala Ser Ser Ile Val Gly Pro Tyr 
    130                 135                 140                 


Asp Glu Val Val Leu Pro Pro Gln Ser Gln Glu Val Asp Trp Glu Val 
145                 150                 155                 160 


Glu Leu Ala Val Val Ile Gly Lys Lys Gly Lys His Ile Lys Ala Thr 
                165                 170                 175     


Asp Ala Met Ala His Val Ala Gly Phe Thr Val Ala His Asp Val Ser 
            180                 185                 190         


Ala Arg Asp Trp Leu Thr Arg Arg Asn Gly Lys Gln Trp Leu Leu Gly 
        195                 200                 205             


Lys Thr Phe Asp Thr Phe Cys Pro Leu Gly Pro Ala Leu Val Thr Lys 
    210                 215                 220                 


Asp Ser Val Ala Asp Pro His Asn Leu Lys Ile Cys Cys Arg Val Asn 
225                 230                 235                 240 


Gly Glu Val Val Gln Ser Ser Asn Thr Asn Gln Met Val Phe Lys Thr 
                245                 250                 255     


Glu Asp Leu Ile Ala Trp Val Ser Gln Phe Val Thr Phe Tyr Pro Gly 
            260                 265                 270         


Asp Val Ile Leu Thr Gly Thr Pro Pro Gly Val Gly Val Phe Arg Lys 
        275                 280                 285             


Pro Pro Val Phe Leu Lys Lys Gly Asp Glu Val Gln Cys Glu Ile Glu 
    290                 295                 300                 


Glu Leu Gly Val Ile Ile Asn Lys Val Val 
305                 310                 


<210>  7959
<211>  641
<212>  DNA
<213>  Homosapiens

<400>  7959
atgggataac agctttgaga tcccttgcca caggtgttgg tgtcacccgt gatctaacct     60

cctgtatggc caaatcccct gcccccatag gccacagatg ccatggccca cgtggccggc    120

ttcactgtgg ctcatgacgt gagtgctcgt gactggctaa caagacgcaa tgggaaacag    180

tggctgctgg gaaaaacctt cgacaccttc tgccctctgg gccctgcctt ggtgaccaag    240

gacagtgtag cagccaccag ttctcccatg ggcttccttc ccaagccccc tagagggaac    300

acaactgcag aggatgtgaa actgcatgcg tgaagtaaat tacaaagaac actgagctga    360

tgggtggatc gggcttcctg cggctgccac catctgaaat aatctaagtt gagcatcatg    420

gagcatagct atcgcaaggc ccaggcattt tccacactac agatgaaagc cagtgtgact    480

cacccagcca ctgtggaaac aacagcattg accacacaca gtgaggggac agcgccaggt    540

tggaggcagt gtgccagagg gcagagcgca gcctcttaac acacagccac ccacaactgt    600

ggtggaggtg gggggtgtcc acatgggcca gccatgccag g                        641


<210>  7960
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  7960

Met Ala His Val Ala Gly Phe Thr Val Ala His Asp Val Ser Ala Arg 
1               5                   10                  15      


Asp Trp Leu Thr Arg Arg Asn Gly Lys Gln Trp Leu Leu Gly Lys Thr 
            20                  25                  30          


Phe Asp Thr Phe Cys Pro Leu Gly Pro Ala Leu Val Thr Lys Asp Ser 
        35                  40                  45              


Val Ala Ala Thr Ser Ser Pro Met Gly Phe Leu Pro Lys Pro Pro Arg 
    50                  55                  60                  


Gly Asn Thr Thr Ala Glu Asp Val Lys Leu His Ala 
65                  70                  75      


<210>  7961
<211>  1238
<212>  DNA
<213>  Homosapiens

<400>  7961
gttccccggc tggatgcggt gactggtgcc agtgctcagg cgcccgctgc ccttgacctc     60

ccgccccgcg agccctaact cagcgcagga ggaccggctg ccgccgccgc cgccgccagc    120

agagccaagc acagtgggaa ctttcagaaa gcactggttg aaggaacgct ggaatccctg    180

ggacttactg cgtagcatgt agtagttgct cctctacaaa agtttcacct tatgaagtat    240

agcaggctct gatgctggtg tctggtagaa gaagattact cacagctctg ctgcaggctc    300

agaagtggcc ctttcaaccc tccagagaca tgagactagt gcagttccgg gcaccccacc    360

tggtggggcc tcacttgggc ctggagacag ggaatggtgg aggggttatc aacctcaatg    420

cctttgaccc cacactccca aagacgatga cgcagttcct agagcaggga gaggccaccc    480

tctcagtggc aagaagagcc ttggctgccc agttgccagt cctaccatgg tcggaggtaa    540

ccttcctggc tccagtcaca tggccagata aggtggtgtg tgtgggcatg aattatgtgg    600

accactgcaa agaacagaac gtgcccgtgc ccaaggagcc catcatcttc agcaagtttg    660

ccagctccat cgtggggccc tatgatgagg tggtcctccc accacagagc caggtcagtg    720

cctccccact gccctcccta gtcactgggc ccatcacaag ggcattctga gctcagtatt    780

gagcctactg gagccacctc tcgctcagta gtgcattcaa cagaaactct acaggattat    840

acacacagta gtaacactgg ccttggaaaa aaaaagttaa tgtacgtgtt ttcctggtta    900

caaaagcaat acaccttcac tgtagataaa acagagataa acatttaaaa attacgtcac    960

ccataatccc actgcccatg gctcggaata ttaatgtttt tctgtctacc ttcccagtgt   1020

ttctccactc ctgtatatgt ttatactgta catatactta ccttttactt aagactccat   1080

caggagcatt ttttcatgcc attaaatatt ctccctgaca tatttaggtt accttggagt   1140

tttgtgatgt acagggtagt ttatattcct gagtacctta ctgctggata cttgtttcca   1200

gtttttggtt tctataaata aatgtcgcaa tgaacatc                           1238


<210>  7962
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  7962

Met Leu Val Ser Gly Arg Arg Arg Leu Leu Thr Ala Leu Leu Gln Ala 
1               5                   10                  15      


Gln Lys Trp Pro Phe Gln Pro Ser Arg Asp Met Arg Leu Val Gln Phe 
            20                  25                  30          


Arg Ala Pro His Leu Val Gly Pro His Leu Gly Leu Glu Thr Gly Asn 
        35                  40                  45              


Gly Gly Gly Val Ile Asn Leu Asn Ala Phe Asp Pro Thr Leu Pro Lys 
    50                  55                  60                  


Thr Met Thr Gln Phe Leu Glu Gln Gly Glu Ala Thr Leu Ser Val Ala 
65                  70                  75                  80  


Arg Arg Ala Leu Ala Ala Gln Leu Pro Val Leu Pro Trp Ser Glu Val 
                85                  90                  95      


Thr Phe Leu Ala Pro Val Thr Trp Pro Asp Lys Val Val Cys Val Gly 
            100                 105                 110         


Met Asn Tyr Val Asp His Cys Lys Glu Gln Asn Val Pro Val Pro Lys 
        115                 120                 125             


Glu Pro Ile Ile Phe Ser Lys Phe Ala Ser Ser Ile Val Gly Pro Tyr 
    130                 135                 140                 


Asp Glu Val Val Leu Pro Pro Gln Ser Gln Val Ser Ala Ser Pro Leu 
145                 150                 155                 160 


Pro Ser Leu Val Thr Gly Pro Ile Thr Arg Ala Phe 
                165                 170         


<210>  7963
<211>  1159
<212>  DNA
<213>  Homosapiens

<400>  7963
gggcgcgcga gagctgctag ggcggtttct ctgcctcggg cctgttgggc agggccggct     60

aaggtgcgcg tgctcgctgg ttctaaccct tctgttgggc gtttctgctg agaggcggga    120

ggcgctgaga gtctgtgcgg aggtccgtgg acagactgct ttgctcgttg ttgctcttcg    180

gaggcggcga tccccgaagg cgagctgaaa tacggctgca ggctacaatt tgcagccgac    240

gattatggaa gacggcaagc gggagaggtg gcccaccctc atggagcgct tgtgctcgga    300

tggcttcgca tttccccaat accccattaa accgtatcat ctgaagagga tccacagagc    360

tgtcttacat ggtaatctag agaaactgaa gtaccttctg ctcacgtatt atgacgccaa    420

taagagagac aggaaggaaa ggaccgccct acatttggcc tgtgccactg gccaaccgga    480

aatggtacat ctcctggtgt ccagaagatg tgagcttaac ctctgcgacc gtgaagacag    540

gacacctctg atcaaggctg tacaactgag gcaggaggct tgtgcaactc ttctgctgca    600

aaatggcgcc aatccaaata ttacggattt ctttggaagg actgctctgc actacgctgt    660

gtataatgaa gatacatcca tgatagaaaa acttctttca catggtacaa atattgaaga    720

atgcagcaag gtataggtca accaatgtta ttttcaaact atctgaaatg catttatttt    780

aacattgaca catgtaaggg tcaatttttc atatttggaa gctcaaacat tccttgaatg    840

aaaatatttt gaaatgcctt aactgtctaa gattttactt taaatattgg aacttttaaa    900

gaagcattat agggaacagc cttttttcat gcacttatgg taaataacta taaaaacaaa    960

tgaattacaa taaatttata attcatgaca actgaatttg ggaaaggtaa tagttaagtg   1020

tttttccact aaattacttt ttttctaatc agtgtgaagt gacacaggaa agtaaaattg   1080

tcccttataa ataggcttta ttttaaatgt caaagaaaat taaagaattt cacaataaat   1140

gtacatgttg ttgctgttg                                                1159


<210>  7964
<211>  163
<212>  PRT
<213>  Homosapiens

<400>  7964

Met Glu Asp Gly Lys Arg Glu Arg Trp Pro Thr Leu Met Glu Arg Leu 
1               5                   10                  15      


Cys Ser Asp Gly Phe Ala Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His 
            20                  25                  30          


Leu Lys Arg Ile His Arg Ala Val Leu His Gly Asn Leu Glu Lys Leu 
        35                  40                  45              


Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys 
    50                  55                  60                  


Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met 
65                  70                  75                  80  


Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg 
                85                  90                  95      


Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala 
            100                 105                 110         


Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asn Pro Asn Ile Thr Asp 
        115                 120                 125             


Phe Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr 
    130                 135                 140                 


Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn Ile Glu Glu Cys 
145                 150                 155                 160 


Ser Lys Val 
            


<210>  7965
<211>  2899
<212>  DNA
<213>  Homosapiens

<400>  7965
ggctaaggtg cgcgtgctcg ctggttctaa cccttctgtt gggcgtttct gctgagaggc     60

gggaggcgct gagagtctgt gcggaggtcc gtggacagac tgctttgctc gttgttgctc    120

ttcggaggcg gcgatccccg aaggcgagct gaaatacggc tgcaggctac aatttgcagc    180

cgacgattat ggaagacggc aagcgggaga ggtggcccac cctcatggag cgcttgtgct    240

cggatggctt cgcatttccc caatacccca ttaaaccgta tcatctgaag aggatccaca    300

gagctgtctt acatggtaat ctagagaaac tgaagtacct tctgctcacg tattatgacg    360

ccaataagag agacaggaag gaaaggaccg ccctacattt ggcctgtgcc actggccaac    420

cggaaatggt acatctcctg gtgtccagaa gatgtgagct taacctctgc gaccgtgaag    480

acaggacacc tctgatcaag gctgtacaac tgaggcagga ggcttgtgca actcttctgc    540

tgcaaaatgg cgccaatcca aatattacgg atttctttgg aaggactgct ctgcactacg    600

ctgtgtataa tgaagataca tccatgatag aaaaacttct ttcacatggt acaaatattg    660

aagaatgcag caagtgtgaa tatcagccac tgttatttgc tgtgagtcga agaaaagtga    720

aaatggtgga atttttatta aagaaaaaag caaatgtaaa tgccattgat tatcttggca    780

gatcagccct catacatgct gttactcttg gagaaaaaga tatagtcatt cttcttctgc    840

agcacaatat tgatgtgctt tctcgagatg cgtttcgaaa gattgcagga gattatgcca    900

ttgaggctaa gaatagagtc atttttgatc taatttatga atacgaaaga aagagatatg    960

aagatcttcc tataaatagc aatccagtgt cttctcagaa acaaccagcc ttgaaggcta   1020

caagtggcaa ggaagattct atttcaaata tagccacaga aataaaggat ggacaaaaat   1080

ctgggacagt gtcttctcag aaacaaccgg ccttgaagga tacaagtgac aaggatgatt   1140

ctgtttcgaa cacagccaca gaaataaaag atgaacaaaa atctgggaca gtgcttcctg   1200

ctgttgaaca gtgtttaaac aggagtctct acagacctga tgctgttgca cagcctgtga   1260

cagagaatga gttttctttg gaatctgaga ttatttcaaa actatacatc ccaaagagaa   1320

agattatttc tccacgatct ataaaagatg tgcttcctcc tgttgaagag gctgttgaca   1380

ggtgtctcta cctactggac cgttttgcac agcctgtgac aaaggataag tttgctttgg   1440

aatctgagaa tatttcagaa ccatacttta cgaacagaag gactatttct caacaatctg   1500

cagaaaattt agatgctgca tgtggcattg acaaaacaga aaatggaaac atgtttgaag   1560

accaaaatgt tgataaggaa ggaaaagcac taccagcaac tggacaaaaa gcaaatgtgt   1620

ctcctgagca accgccttta ttcacgaatc ttctgagcga cctcctttat ccacgcttac   1680

tctgaaagag gcagatccca gttcaaaagc agccatgaga aggaaggatt caccacctcc   1740

aggaaaagtg tcttctcaga aacaaccagc tgagaaggct acaagtgacg acaaagattc   1800

tgtttcaaat atagccacag aaataaagga gggaccaata tctgggacag tgtcttctca   1860

gaaacaacca gctgagaagg ctacaagtga cgagaaagat tctgtttcaa atatagccac   1920

agaaataaag aagggacaac aatctgggac agtgtctcct cagaaacaat cggcctggaa   1980

ggttatattt aaaaagaaag tttctctttt gaatattgcc acaagaataa tgggtggtgg   2040

gaaatctgga acagtgtctt ctcagaaaca accagcctca aaggctacaa gtgacaagac   2100

agattctgct ttgaatatag ctacagaaat aaaggatgga ctacagtgtg ggacagtgtc   2160

ttctcagaag caaccagcct tgaaggctac aactgacgag gaagattctg tttcgaatat   2220

agccacagaa ataaaggatg gagaaaaatc tgggacagtg tcttctcaga aacaaccagc   2280

cttgaaggct acaactgatg agaaagattc tgtttcgaac atagccacag aaataaagga   2340

tggagaaaaa tctgggacag tgtcttctca gaaaccacca gccttgacgg ctacaagtga   2400

cgaggaaggt tctgttttga gtatagccag agaaaacaag gatggagaaa aatctaggac   2460

agtgtcttct cggaaaaaac cagccttgaa ggctacaagt gatgagaagg attctttttc   2520

gaatataacc agaggaaaaa aggatggaga aatatctagg aaagtgtctt ctcagaaacc   2580

accaaccttg aagtgtcttc tgagaaacca ccaggcttga agtgtcttct cggaaaaaac   2640

catccttgga ggccacaagt gatgagaagg attctttttc gaatataacc agagaaaaaa   2700

aggatggaga aatatctagg aaagtgtctt ctcagaaacc accagccttg aagggtacaa   2760

gtgacgagga agattctgtt ttgggtatag ccagagaaaa caaggatgga gaaaaatcta   2820

ggacagtgtc ttctgagaaa ccaccaggct tgaaggctac aagtgatgag aaagattctg   2880

ttttgaatat agccagagg                                                2899


<210>  7966
<211>  498
<212>  PRT
<213>  Homosapiens

<400>  7966

Met Glu Asp Gly Lys Arg Glu Arg Trp Pro Thr Leu Met Glu Arg Leu 
1               5                   10                  15      


Cys Ser Asp Gly Phe Ala Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His 
            20                  25                  30          


Leu Lys Arg Ile His Arg Ala Val Leu His Gly Asn Leu Glu Lys Leu 
        35                  40                  45              


Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys 
    50                  55                  60                  


Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met 
65                  70                  75                  80  


Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg 
                85                  90                  95      


Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala 
            100                 105                 110         


Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asn Pro Asn Ile Thr Asp 
        115                 120                 125             


Phe Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr 
    130                 135                 140                 


Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn Ile Glu Glu Cys 
145                 150                 155                 160 


Ser Lys Cys Glu Tyr Gln Pro Leu Leu Phe Ala Val Ser Arg Arg Lys 
                165                 170                 175     


Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Val Asn Ala 
            180                 185                 190         


Ile Asp Tyr Leu Gly Arg Ser Ala Leu Ile His Ala Val Thr Leu Gly 
        195                 200                 205             


Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn Ile Asp Val Leu 
    210                 215                 220                 


Ser Arg Asp Ala Phe Arg Lys Ile Ala Gly Asp Tyr Ala Ile Glu Ala 
225                 230                 235                 240 


Lys Asn Arg Val Ile Phe Asp Leu Ile Tyr Glu Tyr Glu Arg Lys Arg 
                245                 250                 255     


Tyr Glu Asp Leu Pro Ile Asn Ser Asn Pro Val Ser Ser Gln Lys Gln 
            260                 265                 270         


Pro Ala Leu Lys Ala Thr Ser Gly Lys Glu Asp Ser Ile Ser Asn Ile 
        275                 280                 285             


Ala Thr Glu Ile Lys Asp Gly Gln Lys Ser Gly Thr Val Ser Ser Gln 
    290                 295                 300                 


Lys Gln Pro Ala Leu Lys Asp Thr Ser Asp Lys Asp Asp Ser Val Ser 
305                 310                 315                 320 


Asn Thr Ala Thr Glu Ile Lys Asp Glu Gln Lys Ser Gly Thr Val Leu 
                325                 330                 335     


Pro Ala Val Glu Gln Cys Leu Asn Arg Ser Leu Tyr Arg Pro Asp Ala 
            340                 345                 350         


Val Ala Gln Pro Val Thr Glu Asn Glu Phe Ser Leu Glu Ser Glu Ile 
        355                 360                 365             


Ile Ser Lys Leu Tyr Ile Pro Lys Arg Lys Ile Ile Ser Pro Arg Ser 
    370                 375                 380                 


Ile Lys Asp Val Leu Pro Pro Val Glu Glu Ala Val Asp Arg Cys Leu 
385                 390                 395                 400 


Tyr Leu Leu Asp Arg Phe Ala Gln Pro Val Thr Lys Asp Lys Phe Ala 
                405                 410                 415     


Leu Glu Ser Glu Asn Ile Ser Glu Pro Tyr Phe Thr Asn Arg Arg Thr 
            420                 425                 430         


Ile Ser Gln Gln Ser Ala Glu Asn Leu Asp Ala Ala Cys Gly Ile Asp 
        435                 440                 445             


Lys Thr Glu Asn Gly Asn Met Phe Glu Asp Gln Asn Val Asp Lys Glu 
    450                 455                 460                 


Gly Lys Ala Leu Pro Ala Thr Gly Gln Lys Ala Asn Val Ser Pro Glu 
465                 470                 475                 480 


Gln Pro Pro Leu Phe Thr Asn Leu Leu Ser Asp Leu Leu Tyr Pro Arg 
                485                 490                 495     


Leu Leu 
        


<210>  7967
<211>  724
<212>  DNA
<213>  Homosapiens

<400>  7967
gagaggcggg aggcgctgag agtctgtgcg gaggtccgtg gacagactgc tttgctcgtt     60

gttgctcttc ggaggcggcg atccccgaag gcgagctgaa atacggctgc aggctacaat    120

ttgcagccga cgattatgga agacggcaag cgggagaggt ggcccaccct catggagcgc    180

ttgtgctcgg atggcttcgc atttccccaa taccccatta aaccgtatca tctgaagagg    240

atccacagag ctgtcttaca tggtaatcta gagaaactga agtaccttct gctcacgtat    300

tatgacgcca ataagagaga caggaaggaa aggaccgccc tacatttggc ctgtgccact    360

ggccaaccgg aaatggtaca tctcctggtg tccagaagat gtgagcttaa cctctgcgac    420

cgtgaagaca ggacacctct gatcaaggct gtacaactga ggcaggaggc ttgtgcaact    480

cttctgctgc aaaatggcgc caatccaaat attacggatt tctttggaag gactgctctg    540

cactacgctg tgtataatga agatacatcc atgatagaaa aacttctttc acatggtaca    600

aatattgaag aatgcagcaa gtgtcttctc agaaacaacc agccttgaag gctacaagtg    660

gcaaggaaga ttctatttca aatatagcca cagaaataaa ggatggacaa aaatctggga    720

cagg                                                                 724


<210>  7968
<211>  170
<212>  PRT
<213>  Homosapiens

<400>  7968

Met Glu Asp Gly Lys Arg Glu Arg Trp Pro Thr Leu Met Glu Arg Leu 
1               5                   10                  15      


Cys Ser Asp Gly Phe Ala Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His 
            20                  25                  30          


Leu Lys Arg Ile His Arg Ala Val Leu His Gly Asn Leu Glu Lys Leu 
        35                  40                  45              


Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys 
    50                  55                  60                  


Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met 
65                  70                  75                  80  


Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg 
                85                  90                  95      


Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala 
            100                 105                 110         


Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asn Pro Asn Ile Thr Asp 
        115                 120                 125             


Phe Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr 
    130                 135                 140                 


Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn Ile Glu Glu Cys 
145                 150                 155                 160 


Ser Lys Cys Leu Leu Arg Asn Asn Gln Pro 
                165                 170 


<210>  7969
<211>  737
<212>  DNA
<213>  Homosapiens

<400>  7969
gcgctgagag tctgtgcgga ggtccgtgga cagactgctt tgctcgttgt tgctcttcgg     60

aggcggcgat ccccgaaggc gagctgaaat acggctgcag gctacaattt gcagccgacg    120

attatggaag acggcaagcg ggagaggtgg cccaccctca tggagcgctt gtgctcggat    180

ggcttcgcat ttccccaata ccccattaaa ccgtatcatc tgaagaggat ccacagagct    240

gtcttacatg gtaatctaga gaaactgaag taccttctgc tcacgtatta tgacgccaat    300

aagagagaca ggaaggaaag gaccgcccta catttggcct gtgccactgg ccaaccggaa    360

atggtacatc tcctggtgtc cagaagatgt gagcttaacc tctgcgaccg tgaagacagg    420

acacctctga tcaaggctgt acaactgagg caggaggctt gtgcaactct tctgctgcaa    480

aatggcgcca atccaaatat tacggatttc tttggaagga ctgctctgca ctacgctgtg    540

tataatgaag atacatccat gatagaaaaa cttctttcac atggtacaaa tattgaagaa    600

tgcagcaagg tataggtcaa ccaatgttat tttcaaacta tctgaaatgc atttatttta    660

acattgacac atgtaagggt caatttttca tatttggaag ctcaaacatt ccttgaatga    720

aaatattttg aaatgcc                                                   737


<210>  7970
<211>  163
<212>  PRT
<213>  Homosapiens

<400>  7970

Met Glu Asp Gly Lys Arg Glu Arg Trp Pro Thr Leu Met Glu Arg Leu 
1               5                   10                  15      


Cys Ser Asp Gly Phe Ala Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His 
            20                  25                  30          


Leu Lys Arg Ile His Arg Ala Val Leu His Gly Asn Leu Glu Lys Leu 
        35                  40                  45              


Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys 
    50                  55                  60                  


Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met 
65                  70                  75                  80  


Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg 
                85                  90                  95      


Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala 
            100                 105                 110         


Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asn Pro Asn Ile Thr Asp 
        115                 120                 125             


Phe Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr 
    130                 135                 140                 


Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn Ile Glu Glu Cys 
145                 150                 155                 160 


Ser Lys Val 
            


<210>  7971
<211>  624
<212>  DNA
<213>  Homosapiens

<400>  7971
gcggaggtcc gtggacagac tgctttgctc gttgttgctc ttcggaggcg gcgatccccg     60

aaggcgagct gaaatacggc tgcaggctac aatttgcagc cgacgattat ggaagacggc    120

aagcgggaga ggtggcccac cctcatggag cgcttgtgct cggatggctt cgcatttccc    180

caatacccca ttaaaccgta tcatctgaag aggatccaca gagctgtctt acatggtaat    240

ctagagaaac tgaagtacct tctgctcacg tattatgacg ccaataagag agacaggaag    300

gaaaggaccg ccctacattt ggcctgtgcc actggccaac cggaaatggt acatctcctg    360

gtgtccagaa gatgtgagct taacctctgc gaccgtgaag acaggacacc tctgatcaag    420

gtatatagta gctgactctt tgagcatgag atggatttgg ttgaagtaca taggataaaa    480

tgaatttatc tcattggaat accaccatat aactagtagg aaatcctacg gagtgtttat    540

tttgattttt cagtatttgc atgtttctcg gtctaatact gacaggctgt acaactgagg    600

caggaggctt gtgcaactct tctg                                           624


<210>  7972
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  7972

Met Glu Asp Gly Lys Arg Glu Arg Trp Pro Thr Leu Met Glu Arg Leu 
1               5                   10                  15      


Cys Ser Asp Gly Phe Ala Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His 
            20                  25                  30          


Leu Lys Arg Ile His Arg Ala Val Leu His Gly Asn Leu Glu Lys Leu 
        35                  40                  45              


Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys 
    50                  55                  60                  


Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met 
65                  70                  75                  80  


Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg 
                85                  90                  95      


Glu Asp Arg Thr Pro Leu Ile Lys Val Tyr Ser Ser 
            100                 105             


<210>  7973
<211>  362
<212>  DNA
<213>  Homosapiens

<400>  7973
gaatatttca gaaccatact ttacgaacag aaggactatt tctcaacaat ctgcagaaaa     60

tttagatgct gcatgtggca ttgacaaaac agaaaatgga aacatgtttg aagaccaaaa    120

tgttgataag gaaggaaaag cactaccagc aactggacaa aaagcaaatg tgaatgaaaa    180

gatggcaaga gaactaaagt tgagaatcca gaagttgaaa atatcagaag ccttcatgac    240

tgtggatgac atgagtattt ttagaaacga tttttctcca agtagatatc taaagtaatg    300

attgagagca tttcctgcca gcagaagcga atgatacatt ttcttttctt tttttttgag    360

ac                                                                   362


<210>  7974
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  7974

Met Phe Glu Asp Gln Asn Val Asp Lys Glu Gly Lys Ala Leu Pro Ala 
1               5                   10                  15      


Thr Gly Gln Lys Ala Asn Val Asn Glu Lys Met Ala Arg Glu Leu Lys 
            20                  25                  30          


Leu Arg Ile Gln Lys Leu Lys Ile Ser Glu Ala Phe Met Thr Val Asp 
        35                  40                  45              


Asp Met Ser Ile Phe Arg Asn Asp Phe Ser Pro Ser Arg Tyr Leu Lys 
    50                  55                  60                  


<210>  7975
<211>  483
<212>  DNA
<213>  Homosapiens

<400>  7975
gataccttgc atgaaagaca tggaggatga tgtagcacct gctttgacat tgattctcag     60

gtgtatgagt tgctcctctg attttagatc acttttgtcc tcatcattca gcatattcac    120

attgatagta acactgtttc attttagttt tagacatatg aaaaatcata ccatgattga    180

cattgtaagg gtttattttg tgaaacctgt atttcttttt tttcagtgta tttctggtca    240

tgttccagtc cccagacaca aaaatcaaag cctatactaa tacaggcagg agcatacagc    300

ttgatgctaa cacttcatga atgtatagat aactttatca tatttacata tgagtgatta    360

tgtatccctt ttgcttttca gtgtcttctc agaaacaacc agcctcaaag gctacaagtg    420

acaagacaga ttctgctttg aatatagcta cagaaataaa ggatggacta cagtgtggga    480

cag                                                                  483


<210>  7976
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  7976

Met Tyr Pro Phe Cys Phe Ser Val Ser Ser Gln Lys Gln Pro Ala Ser 
1               5                   10                  15      


Lys Ala Thr Ser Asp Lys Thr Asp Ser Ala Leu Asn Ile Ala Thr Glu 
            20                  25                  30          


Ile Lys Asp Gly Leu Gln Cys Gly 
        35                  40  


<210>  7977
<211>  484
<212>  DNA
<213>  Homosapiens

<400>  7977
aagttaaaga gcatgatgaa tgtttgcagt ataatggtgt aaatcctctt aatttgttgc     60

atgaaagaca tgtgggatca tgtagcacct gttttgacat tgattctcac gtatatgagt    120

tgctcctctg attttagatc acatttgttc tcatcactcg gcatatccac attgagattg    180

acacggtttt attttagttt tcgacacatg acaaatctta ccatgtttga aatcgtaagg    240

gtgtatttca cagagcctgt gttccctttt ttcagtgtat ttctgtcatg ttctgatccc    300

cagacacaaa gtagaagcca tcaaagcctc cactaataca agcaggagga cagaggttga    360

tgctaacact gtgtgaatct atggataatt ttatcatgtt tacatgtgag tgattatgta    420

tcccttttgc ttttcagtgt cttctcggaa aaaaccatcc ttggaggcca caagtgatga    480

gaag                                                                 484


<210>  7978
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  7978

Met Lys Asp Met Trp Asp His Val Ala Pro Val Leu Thr Leu Ile Leu 
1               5                   10                  15      


Thr Tyr Met Ser Cys Ser Ser Asp Phe Arg Ser His Leu Phe Ser Ser 
            20                  25                  30          


Leu Gly Ile Ser Thr Leu Arg Leu Thr Arg Phe Tyr Phe Ser Phe Arg 
        35                  40                  45              


His Met Thr Asn Leu Thr Met Phe Glu Ile Val Arg Val Tyr Phe Thr 
    50                  55                  60                  


Glu Pro Val Phe Pro Phe Phe Ser Val Phe Leu Ser Cys Ser Asp Pro 
65                  70                  75                  80  


Gln Thr Gln Ser Arg Ser His Gln Ser Leu His 
                85                  90      


<210>  7979
<211>  246
<212>  DNA
<213>  Homosapiens

<400>  7979
ctcagcgtat ttctgtcacg ttctaatccc cagaccaaaa ttagaagcca tcaaagcata     60

cgctaataca ggcaggagga cagaggctga tgctaacact gcatgaatgt atggataatt    120

ttgtcatttt tacatatgag tgattaggaa tcccttttac ttttcagtgt cttctgagaa    180

accaccaggc ttgaaggcta caagtgatga gaaagattct gttttgaata tagccagagg    240

aaaaaa                                                               246


<210>  7980
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  7980

Val Ile Arg Asn Pro Phe Tyr Phe Ser Val Ser Ser Glu Lys Pro Pro 
1               5                   10                  15      


Gly Leu Lys Ala Thr Ser Asp Glu Lys Asp Ser Val Leu Asn Ile Ala 
            20                  25                  30          


Arg Gly 
        


<210>  7981
<211>  400
<212>  DNA
<213>  Homosapiens

<400>  7981
tatatttcat ggagcctgtg ttcccttttt cagtgtattt ctgtcatgtt ctgatcccca     60

gacacaaagt agaagccatc aaagcctcca ctaatacagg caggaggaca gaggttgatg    120

ctaacactgt gtgaatgtat ggataacttt atcatattta catgtgagtg attatgtatc    180

ccttttgctt ttcagtgtct tctcggaaaa aaccagcctt gaagtgtctt ctccgaaaca    240

accagcattg aaggctatct gtgacaagga agattctgtt ccgaatatgg ccacggaaaa    300

aaaggatgaa caaatatctg ggacaggtaa ttttgcaaac acatttaata tgatgttcgg    360

tcagggtaga agagaacttc tcttcaccaa ataaaacagc                          400


<210>  7982
<211>  41
<212>  PRT
<213>  Homosapiens

<400>  7982

Met Glu Pro Val Phe Pro Phe Ser Val Tyr Phe Cys His Val Leu Ile 
1               5                   10                  15      


Pro Arg His Lys Val Glu Ala Ile Lys Ala Ser Thr Asn Thr Gly Arg 
            20                  25                  30          


Arg Thr Glu Val Asp Ala Asn Thr Val 
        35                  40      


<210>  7983
<211>  5042
<212>  DNA
<213>  Homosapiens

<400>  7983
attgaggcta atatattatc ctttggtgcc atgagtggat gaagaaactt tcagaaggct     60

aaacgagtgg atacaagaaa cttaggcaaa ttattacacc acaggggtgt gagaaataat    120

gaatattctc tactaggttt cagcaaacat aatccaagct gatcaattta ggacacttcc    180

actgaagaga cgtgaagtgt acgttcaact gaagtgtcat tgtaattgtg tgccttctca    240

gttattgggc aagttaaaga gcatgatgaa tgtttgtact ataatggtgt aaatccttct    300

gatttcttgc atggaagaca tgtggcatca tgtagaacct gctttgacat tgattctcaa    360

ttgtatgagt tgctcctctg attttagatc acatttgtcc tcatcacttg gcatatccac    420

attgatattg acacggtttt attttagttt tagacatatg acaaatcatg ccatgtttga    480

aattgtaagt atattttgtg aagcctgtat tcaccttttt cagtgtattt ctgtcatatt    540

ccagtcccga gtcacaaagt agaaaacatc aaagcctata ctaatacagg caggaagata    600

catcttgatg ccaacagtgc aggaatgtat ggataacttt atcatattta catatgagtg    660

attatgtatc ccttttgctt ttcagtgtct tgtcagaaac aaccagcctt gaaggctaca    720

agtgacaaga aagattctgt ttcgaatata cccacagaaa taaaggatgg acaacaatct    780

ggaacagtgt cttctcagaa acaaccggcc tggaaggcta caagtgtcaa gaaagattct    840

gtttcgaata tagccacaga aataaaggat ggacaaatac gtgggacagt gtctcctcag    900

aaacaatcgg cccagaaggt tatatttaaa aagaaagttt ctcttttgaa tattgccaca    960

agaataacag gcggttggaa atctggaaca gagtatcctg agaatctgcc caccttgaag   1020

gctacaattg aaaataaaaa ttctgttctg aatacagcca ccaaaatgaa ggatgtacaa   1080

acatccacac cagcagaaca agacttagaa atggcatcag agggagagca aaagaggctt   1140

gaagaatatg aaaataacca gccacaggtg aaaaaccaaa tacattctag ggatgacctt   1200

gatgacataa ttcagtcatc tcaaacagtc tcagaggacg gtgactcgct ttgctgtaat   1260

tgtaagaatg tcatattact cattgatcaa catgaaatga agtgtaaaga ttgtgttcac   1320

ctattgaaaa ttaaaaatac attttgttta tggaaaagat taataaaact taaagataac   1380

cactgtgagc aacttagagt aaaaattcga aaactgaaaa ataaggctag tgtactacaa   1440

aagagaatat ctgaaaaaga agaaataaaa tcgcagttaa agcatgaaat acttgaattg   1500

gaaaaagaac tctgtagttt gagatttgcc atacagcaag aaaaaaagaa aagaagaaat   1560

gttgaagagg tgcaccaaaa agttagggaa aagttaagaa taacagaaga gcaatatagg   1620

atagaagctg atgtgacaaa accaattaaa ccggctctca aatcagcaga ggtggaattg   1680

aagacaggag gaaataattc aaatcaggtt tctgaaactg atgaaaaaga agacctgctg   1740

catgaaaacc gcttgatgca agatgaaatt gccaggctca ggctggaaaa agacacaata   1800

aaaaaccaaa acctggaaaa gaaatactta aaagactttg aaattgtgaa aagaaagcat   1860

gaagaccttc aaaaggctct aaaacggaat ggggaaacat tagcaaaaac gatagcctgt   1920

tatagtggac agcttgctgc tctgacagat gaaaacacaa cgctccgttc caaactggag   1980

aagcaaagag agagcaggca aagactggaa acagaaatgc aatcatacca ttgtagactg   2040

aatgctgctc gatgtgatca tgatcaaagt cactcatcaa aaagagacca agagcttgct   2100

ttccagggca cagtagataa atgtcgtcac ttacaggaaa atttgaattc tcatgttctg   2160

attctttctc tgcaactttc taaagctgag agtaagtcca gagtcctcaa aactgagctc   2220

cattacacag gagaggctct gaaagaaaag gctttggttt ttgaacacgt gcaaagtgag   2280

ctaaagcaaa aacagagtca aatgaaggac attgaaaaaa tgtacaaaag tggatacaat   2340

acaatggaaa aatgcataga aaaacaggaa agattttgtc aactaaaaaa acaaaatatg   2400

ttgcttcaac agcaactgga tgatgctcgc aacaaagctg acaatcaaga aaaagcaata   2460

cttaatattc aagccagatg tgatgctaga gtacaaaacc ttcaagctga gtgcagaaag   2520

caccgtcttt tactagaaga agacaataaa atgttggtca atgaactgaa tcattcgaaa   2580

gaaaaagaat gccaatatga aaaagagaaa gcagaaagag aagtagctgt gagacagctt   2640

caacaaaaac gagatgatgt cttaaacaaa ggatcagcaa caaaagctct gctggatgct   2700

tcatcgcgtc actgcaccta tttagaaaat gggatgcagg attcaaggaa gaaattagac   2760

cagatgagaa gtcaagtatg tatgcaactt tgcacaccaa caactgttaa tctgtagcta   2820

gttaactaat ataaagtgtt ttggggtact aattttagtg gatggctttc ttttgtattt   2880

ttatgataat taatgttatt aaaattttat agtggatggc tttcttctgt attttcctta   2940

ttattaattt tattaagatt ttattataat gcacctatat cttaatctct ggctttcatt   3000

ctgccatttt ttatacatat atttttttct taaatattta accttaggaa agttgagaat   3060

tatgcatcat ttctcacaga agttgagaga gttttttttt cctgttaaac agtctatttt   3120

taatgatttc tctattggca tggtgaggca agccaggtta attcagagga taatgtctaa   3180

tggaatgttt cagaaaatta tcttcttttt agtctctact tttctgaatg tataaagaac   3240

ctgtgtatac gtatttctta gatttcaggt taacttgttc agaaaggcca ttttactgaa   3300

taaattttta tttcgatgaa aatccttact tcctttgtat tgggctcaga gagcacactc   3360

tgtctctata tgaatatgga cagttagcat ttgccaacat gtatctattt tctcttattt   3420

gtagaaaaag ctaaactaaa aagggggtta tagaaggtca gcaaaggatg ggtttgagat   3480

gtttgggttg gttaagtggg catttagaca acagggcttc tcctttggca tgtttaatgg   3540

acatctttgc agtttaagat gacgctttta aattacttct ctcctaatga tgacctgagt   3600

cctgctattc aatgggagag tcaataagat cctgtaggat cttatttgga actgactttg   3660

tcgattttaa ttttgttcct gcttgttttt aaattttctt gttgtttccc tagaaaggaa   3720

agatgatgct tagttttaaa tatttaaaaa tgtgcaagtt gctttgctat aataaaacta   3780

aatgcataca tacaaaaaat aaaattatag ttgatgtggt agtgtttgga attcaaaata   3840

taaatgctta gcgtgaggta atcctttatc tttccacatt ttaccagttt gtaagtttga   3900

gtatttaatt gataaaatgt aattcaaaag caagaagaat gttgtgtttt agtcctagag   3960

caggggtctg tgaacttttc tgtaaagggc cagatagtgt tatgtaaggc tttgtgagcc   4020

ataagatcct tgttgcaata actcggccct gcaattacag cacaaaagta gccatgaaca   4080

atatgcagac tgaaggggtg tagcagtgtc ccactaaaat tacttacaaa aaacaggtaa   4140

tgggatgatt tctcctagat tatgaccttt tataaataaa aaagattgtg atagtctaaa   4200

atatttcata tatattttgt tgattcattc atctactgat ggacatttag gtcatttcca   4260

aatgtaattt tttaaaattc tttgtttcag tttcaagaaa tacaggatca acttacagct   4320

actataagat gtactaagga gatggaaggc gacacacaaa agtaaaattt gaagcagcac   4380

acaaaataac ttgagtattt ataaagcaaa agagcactgt agtatgaaaa ttgtatcagt   4440

tatgataatt agtatgtctt tgtgaagcca aaaaagtttc atttgtaagc tatatcgaaa   4500

tacatcattt ttctacatta ttcctaaatt ttgcatatta tcaccaaaac acaggtagaa   4560

aatgacacag tagcccaatc gtctactttt gtgattgcta agaatttgtg taattatacc   4620

ttcagaagtt tgtttagaat ttacatgatt taaaaaaaat tacgtgtgag agtaattatt   4680

ttaaaatgca cattttaggc ttgaagtaga acatgtgatg atgagaaaaa ttattaaaaa   4740

acaggatgac caaattgagc ggcttgagaa aatcctgcag cattcaagtt tggtaagctg   4800

atctcttaat ttctgtcata ctgaaaagga attttatttt tccagtagga tgggttaaat   4860

atcccttgtc caaaatgctt gggaccaaaa gtagattttt ttcagatttt ggaatatttg   4920

tatataccta atgaaatatc ttgcggatgg tacctgagtc taaacatgaa attcatttgt   4980

gtttcatata taccttatgc acatagcctg aaggtaattc tctacaatgt tttacagtaa   5040

tt                                                                  5042


<210>  7984
<211>  717
<212>  PRT
<213>  Homosapiens

<400>  7984

Met Tyr Pro Phe Cys Phe Ser Val Ser Cys Gln Lys Gln Pro Ala Leu 
1               5                   10                  15      


Lys Ala Thr Ser Asp Lys Lys Asp Ser Val Ser Asn Ile Pro Thr Glu 
            20                  25                  30          


Ile Lys Asp Gly Gln Gln Ser Gly Thr Val Ser Ser Gln Lys Gln Pro 
        35                  40                  45              


Ala Trp Lys Ala Thr Ser Val Lys Lys Asp Ser Val Ser Asn Ile Ala 
    50                  55                  60                  


Thr Glu Ile Lys Asp Gly Gln Ile Arg Gly Thr Val Ser Pro Gln Lys 
65                  70                  75                  80  


Gln Ser Ala Gln Lys Val Ile Phe Lys Lys Lys Val Ser Leu Leu Asn 
                85                  90                  95      


Ile Ala Thr Arg Ile Thr Gly Gly Trp Lys Ser Gly Thr Glu Tyr Pro 
            100                 105                 110         


Glu Asn Leu Pro Thr Leu Lys Ala Thr Ile Glu Asn Lys Asn Ser Val 
        115                 120                 125             


Leu Asn Thr Ala Thr Lys Met Lys Asp Val Gln Thr Ser Thr Pro Ala 
    130                 135                 140                 


Glu Gln Asp Leu Glu Met Ala Ser Glu Gly Glu Gln Lys Arg Leu Glu 
145                 150                 155                 160 


Glu Tyr Glu Asn Asn Gln Pro Gln Val Lys Asn Gln Ile His Ser Arg 
                165                 170                 175     


Asp Asp Leu Asp Asp Ile Ile Gln Ser Ser Gln Thr Val Ser Glu Asp 
            180                 185                 190         


Gly Asp Ser Leu Cys Cys Asn Cys Lys Asn Val Ile Leu Leu Ile Asp 
        195                 200                 205             


Gln His Glu Met Lys Cys Lys Asp Cys Val His Leu Leu Lys Ile Lys 
    210                 215                 220                 


Asn Thr Phe Cys Leu Trp Lys Arg Leu Ile Lys Leu Lys Asp Asn His 
225                 230                 235                 240 


Cys Glu Gln Leu Arg Val Lys Ile Arg Lys Leu Lys Asn Lys Ala Ser 
                245                 250                 255     


Val Leu Gln Lys Arg Ile Ser Glu Lys Glu Glu Ile Lys Ser Gln Leu 
            260                 265                 270         


Lys His Glu Ile Leu Glu Leu Glu Lys Glu Leu Cys Ser Leu Arg Phe 
        275                 280                 285             


Ala Ile Gln Gln Glu Lys Lys Lys Arg Arg Asn Val Glu Glu Val His 
    290                 295                 300                 


Gln Lys Val Arg Glu Lys Leu Arg Ile Thr Glu Glu Gln Tyr Arg Ile 
305                 310                 315                 320 


Glu Ala Asp Val Thr Lys Pro Ile Lys Pro Ala Leu Lys Ser Ala Glu 
                325                 330                 335     


Val Glu Leu Lys Thr Gly Gly Asn Asn Ser Asn Gln Val Ser Glu Thr 
            340                 345                 350         


Asp Glu Lys Glu Asp Leu Leu His Glu Asn Arg Leu Met Gln Asp Glu 
        355                 360                 365             


Ile Ala Arg Leu Arg Leu Glu Lys Asp Thr Ile Lys Asn Gln Asn Leu 
    370                 375                 380                 


Glu Lys Lys Tyr Leu Lys Asp Phe Glu Ile Val Lys Arg Lys His Glu 
385                 390                 395                 400 


Asp Leu Gln Lys Ala Leu Lys Arg Asn Gly Glu Thr Leu Ala Lys Thr 
                405                 410                 415     


Ile Ala Cys Tyr Ser Gly Gln Leu Ala Ala Leu Thr Asp Glu Asn Thr 
            420                 425                 430         


Thr Leu Arg Ser Lys Leu Glu Lys Gln Arg Glu Ser Arg Gln Arg Leu 
        435                 440                 445             


Glu Thr Glu Met Gln Ser Tyr His Cys Arg Leu Asn Ala Ala Arg Cys 
    450                 455                 460                 


Asp His Asp Gln Ser His Ser Ser Lys Arg Asp Gln Glu Leu Ala Phe 
465                 470                 475                 480 


Gln Gly Thr Val Asp Lys Cys Arg His Leu Gln Glu Asn Leu Asn Ser 
                485                 490                 495     


His Val Leu Ile Leu Ser Leu Gln Leu Ser Lys Ala Glu Ser Lys Ser 
            500                 505                 510         


Arg Val Leu Lys Thr Glu Leu His Tyr Thr Gly Glu Ala Leu Lys Glu 
        515                 520                 525             


Lys Ala Leu Val Phe Glu His Val Gln Ser Glu Leu Lys Gln Lys Gln 
    530                 535                 540                 


Ser Gln Met Lys Asp Ile Glu Lys Met Tyr Lys Ser Gly Tyr Asn Thr 
545                 550                 555                 560 


Met Glu Lys Cys Ile Glu Lys Gln Glu Arg Phe Cys Gln Leu Lys Lys 
                565                 570                 575     


Gln Asn Met Leu Leu Gln Gln Gln Leu Asp Asp Ala Arg Asn Lys Ala 
            580                 585                 590         


Asp Asn Gln Glu Lys Ala Ile Leu Asn Ile Gln Ala Arg Cys Asp Ala 
        595                 600                 605             


Arg Val Gln Asn Leu Gln Ala Glu Cys Arg Lys His Arg Leu Leu Leu 
    610                 615                 620                 


Glu Glu Asp Asn Lys Met Leu Val Asn Glu Leu Asn His Ser Lys Glu 
625                 630                 635                 640 


Lys Glu Cys Gln Tyr Glu Lys Glu Lys Ala Glu Arg Glu Val Ala Val 
                645                 650                 655     


Arg Gln Leu Gln Gln Lys Arg Asp Asp Val Leu Asn Lys Gly Ser Ala 
            660                 665                 670         


Thr Lys Ala Leu Leu Asp Ala Ser Ser Arg His Cys Thr Tyr Leu Glu 
        675                 680                 685             


Asn Gly Met Gln Asp Ser Arg Lys Lys Leu Asp Gln Met Arg Ser Gln 
    690                 695                 700                 


Val Cys Met Gln Leu Cys Thr Pro Thr Thr Val Asn Leu 
705                 710                 715         


<210>  7985
<211>  1301
<212>  DNA
<213>  Homosapiens

<400>  7985
ttaggtttct gaaactgatg aaaaagaaga cctgctgcat gaaaaccgct tgatgcaaga     60

tgaaattgcc aggctcaggc tggaaaaaga cacaataaaa aaccaaaacc tggaaaagaa    120

atacttaaaa gactttgaaa ttgtgaaaag aaagcatgaa gaccttcaaa aggctctaaa    180

acggaatggg gaaacattag caaaaacgat agcctgttat agtggacagc ttgctgctct    240

gacagatgaa aacacaacgc tccgttccaa actggagaag caaagagaga gcaggcaaag    300

actggaaaca gaaatgcaat cataccattg tagactgaat gctgctcgat gtgatcatga    360

tcaaagtcac tcatcaaaaa gagaccaaga gcttgctttc cagggcacag tagataaatg    420

tcgtcactta caggaaaatt tgaattctca tgttctgatt ctttctctgc aactttctaa    480

agctgagagt aagtccagag tcctcaaaac tgagctccat tacacaggag aggctctgaa    540

agaaaaggct ttggtttttg aacacgtgca aagtgagcta aagcaaaaac agagtcaaat    600

gaaggacatt gaaaaaatgt acaaaagtgg atacaataca atggaaaaat gcatagaaaa    660

acaggaaaga ttttgtcaac taaaaaaaca aaatatgttg cttcaacagc aactggatga    720

tgctcgcaac aaagctgaca atcaagaaaa agcaatactt aatattcaag ccagatgtga    780

tgctagagta caaaaccttc aagctgagtg cagaaagcac cgtcttttac tagaagaaga    840

caataaaatg ttggtcaatg aactgaatca ttcgaaagaa aaagaatgcc aatatgaaaa    900

agagaaagca gaaagagaag tagctgtgag acagcttcaa caaaaacgag atgatgtctt    960

aaacaaagga tcagcaacaa aagctctgct ggatgcttca tcgcgtcact gcacctattt   1020

agaaaatggg atgcaggatt caaggaagaa attagaccag atgagaagtc aatttcaaga   1080

aatacaggat caacttacag ctactataag atgtactaag gagatggaag gcgacacaca   1140

aaagtaaaat ttgaagcagc acacaaaata acttgagtat ttataaagca aaagagcact   1200

gtagtatgaa aattgtatca gttatgataa ttagtatgtc tttgtgaagc caaaaaagtt   1260

tcatttgtaa gctatatcga aatacatcat ttttctacat t                       1301


<210>  7986
<211>  364
<212>  PRT
<213>  Homosapiens

<400>  7986

Met Gln Asp Glu Ile Ala Arg Leu Arg Leu Glu Lys Asp Thr Ile Lys 
1               5                   10                  15      


Asn Gln Asn Leu Glu Lys Lys Tyr Leu Lys Asp Phe Glu Ile Val Lys 
            20                  25                  30          


Arg Lys His Glu Asp Leu Gln Lys Ala Leu Lys Arg Asn Gly Glu Thr 
        35                  40                  45              


Leu Ala Lys Thr Ile Ala Cys Tyr Ser Gly Gln Leu Ala Ala Leu Thr 
    50                  55                  60                  


Asp Glu Asn Thr Thr Leu Arg Ser Lys Leu Glu Lys Gln Arg Glu Ser 
65                  70                  75                  80  


Arg Gln Arg Leu Glu Thr Glu Met Gln Ser Tyr His Cys Arg Leu Asn 
                85                  90                  95      


Ala Ala Arg Cys Asp His Asp Gln Ser His Ser Ser Lys Arg Asp Gln 
            100                 105                 110         


Glu Leu Ala Phe Gln Gly Thr Val Asp Lys Cys Arg His Leu Gln Glu 
        115                 120                 125             


Asn Leu Asn Ser His Val Leu Ile Leu Ser Leu Gln Leu Ser Lys Ala 
    130                 135                 140                 


Glu Ser Lys Ser Arg Val Leu Lys Thr Glu Leu His Tyr Thr Gly Glu 
145                 150                 155                 160 


Ala Leu Lys Glu Lys Ala Leu Val Phe Glu His Val Gln Ser Glu Leu 
                165                 170                 175     


Lys Gln Lys Gln Ser Gln Met Lys Asp Ile Glu Lys Met Tyr Lys Ser 
            180                 185                 190         


Gly Tyr Asn Thr Met Glu Lys Cys Ile Glu Lys Gln Glu Arg Phe Cys 
        195                 200                 205             


Gln Leu Lys Lys Gln Asn Met Leu Leu Gln Gln Gln Leu Asp Asp Ala 
    210                 215                 220                 


Arg Asn Lys Ala Asp Asn Gln Glu Lys Ala Ile Leu Asn Ile Gln Ala 
225                 230                 235                 240 


Arg Cys Asp Ala Arg Val Gln Asn Leu Gln Ala Glu Cys Arg Lys His 
                245                 250                 255     


Arg Leu Leu Leu Glu Glu Asp Asn Lys Met Leu Val Asn Glu Leu Asn 
            260                 265                 270         


His Ser Lys Glu Lys Glu Cys Gln Tyr Glu Lys Glu Lys Ala Glu Arg 
        275                 280                 285             


Glu Val Ala Val Arg Gln Leu Gln Gln Lys Arg Asp Asp Val Leu Asn 
    290                 295                 300                 


Lys Gly Ser Ala Thr Lys Ala Leu Leu Asp Ala Ser Ser Arg His Cys 
305                 310                 315                 320 


Thr Tyr Leu Glu Asn Gly Met Gln Asp Ser Arg Lys Lys Leu Asp Gln 
                325                 330                 335     


Met Arg Ser Gln Phe Gln Glu Ile Gln Asp Gln Leu Thr Ala Thr Ile 
            340                 345                 350         


Arg Cys Thr Lys Glu Met Glu Gly Asp Thr Gln Lys 
        355                 360                 


<210>  7987
<211>  1338
<212>  DNA
<213>  Homosapiens

<400>  7987
ttaggtttct gaaactgatg aaaaagaaga cctgctgcat gaaaaccgct tgatgcaaga     60

tgaaattgcc aggctcaggc tggaaaaaga cacaataaaa aaccaaaacc tggaaaagaa    120

atacttaaaa gactttgaaa ttgtgaaaag aaagcatgaa gaccttcaaa aggctctaaa    180

acggaatggg gaaacattag caaaaacgat agcctgttat agtggacagc ttgctgctct    240

gacagatgaa aacacaacgc tccgttccaa actggagaag caaagagaga gcaggcaaag    300

actggaaaca gaaatgcaat cataccattg tagactgaat gctgctcgat gtgatcatga    360

tcaaagtcac tcatcaaaaa gagaccaaga gcttgctttc cagggcacag tagataaatg    420

tcgtcactta caggaaaatt tgaattctca tgttctgatt ctttctctgc aactttctaa    480

agctgagagt aagtccagag tcctcaaaac tgagctccat tacacaggag aggctctgaa    540

agaaaaggct ttggtttttg aacacgtgca aagtgagcta aagcaaaaac agagtcaaat    600

gaaggacatt gaaaaaatgt acaaaagtgg atacaataca atggaaaaat gcatagaaaa    660

acaggaaaga ttttgtcaac taaaaaaaca aaatatgttg cttcaacagc aactggatga    720

tgctcgcaac aaagctgaca atcaagaaaa agcaatactt aatattcaag ccagatgtga    780

tgctagagta caaaaccttc aagctgagtg cagaaagcac cgtcttttac tagaagaaga    840

caataaaatg ttggtcaatg aactgaatca ttcgaaagaa aaagaatgcc aatatgaaaa    900

agagaaagca gaaagagaag tagctgtgag acagcttcaa caaaaacgag atgatgtctt    960

aaacaaagga tcagcaacaa aagctctgct ggatgcttca tcgcgtcact gcacctattt   1020

agaaaatggg atgcaggatt caaggaagaa attagaccag atgagaagtc aatttcaaga   1080

aatacaggat caacttacag ctactataag atgtactaag gagatggaag gcgacacaca   1140

aaagcttgaa gtagaacatg tgatgatgag aaaaattatt aaaaaacagg atgaccaaat   1200

tgagcggctt gagaaaatcc tgcagcattc aagtttgatg ctgcaggtgt ttgagagcta   1260

gatgaaggta tgttgccaaa atttatgaat taaattcaaa tcattgattt ctgaaataaa   1320

ctctaagtag tgaacggt                                                 1338


<210>  7988
<211>  402
<212>  PRT
<213>  Homosapiens

<400>  7988

Met Gln Asp Glu Ile Ala Arg Leu Arg Leu Glu Lys Asp Thr Ile Lys 
1               5                   10                  15      


Asn Gln Asn Leu Glu Lys Lys Tyr Leu Lys Asp Phe Glu Ile Val Lys 
            20                  25                  30          


Arg Lys His Glu Asp Leu Gln Lys Ala Leu Lys Arg Asn Gly Glu Thr 
        35                  40                  45              


Leu Ala Lys Thr Ile Ala Cys Tyr Ser Gly Gln Leu Ala Ala Leu Thr 
    50                  55                  60                  


Asp Glu Asn Thr Thr Leu Arg Ser Lys Leu Glu Lys Gln Arg Glu Ser 
65                  70                  75                  80  


Arg Gln Arg Leu Glu Thr Glu Met Gln Ser Tyr His Cys Arg Leu Asn 
                85                  90                  95      


Ala Ala Arg Cys Asp His Asp Gln Ser His Ser Ser Lys Arg Asp Gln 
            100                 105                 110         


Glu Leu Ala Phe Gln Gly Thr Val Asp Lys Cys Arg His Leu Gln Glu 
        115                 120                 125             


Asn Leu Asn Ser His Val Leu Ile Leu Ser Leu Gln Leu Ser Lys Ala 
    130                 135                 140                 


Glu Ser Lys Ser Arg Val Leu Lys Thr Glu Leu His Tyr Thr Gly Glu 
145                 150                 155                 160 


Ala Leu Lys Glu Lys Ala Leu Val Phe Glu His Val Gln Ser Glu Leu 
                165                 170                 175     


Lys Gln Lys Gln Ser Gln Met Lys Asp Ile Glu Lys Met Tyr Lys Ser 
            180                 185                 190         


Gly Tyr Asn Thr Met Glu Lys Cys Ile Glu Lys Gln Glu Arg Phe Cys 
        195                 200                 205             


Gln Leu Lys Lys Gln Asn Met Leu Leu Gln Gln Gln Leu Asp Asp Ala 
    210                 215                 220                 


Arg Asn Lys Ala Asp Asn Gln Glu Lys Ala Ile Leu Asn Ile Gln Ala 
225                 230                 235                 240 


Arg Cys Asp Ala Arg Val Gln Asn Leu Gln Ala Glu Cys Arg Lys His 
                245                 250                 255     


Arg Leu Leu Leu Glu Glu Asp Asn Lys Met Leu Val Asn Glu Leu Asn 
            260                 265                 270         


His Ser Lys Glu Lys Glu Cys Gln Tyr Glu Lys Glu Lys Ala Glu Arg 
        275                 280                 285             


Glu Val Ala Val Arg Gln Leu Gln Gln Lys Arg Asp Asp Val Leu Asn 
    290                 295                 300                 


Lys Gly Ser Ala Thr Lys Ala Leu Leu Asp Ala Ser Ser Arg His Cys 
305                 310                 315                 320 


Thr Tyr Leu Glu Asn Gly Met Gln Asp Ser Arg Lys Lys Leu Asp Gln 
                325                 330                 335     


Met Arg Ser Gln Phe Gln Glu Ile Gln Asp Gln Leu Thr Ala Thr Ile 
            340                 345                 350         


Arg Cys Thr Lys Glu Met Glu Gly Asp Thr Gln Lys Leu Glu Val Glu 
        355                 360                 365             


His Val Met Met Arg Lys Ile Ile Lys Lys Gln Asp Asp Gln Ile Glu 
    370                 375                 380                 


Arg Leu Glu Lys Ile Leu Gln His Ser Ser Leu Met Leu Gln Val Phe 
385                 390                 395                 400 


Glu Ser 
        


<210>  7989
<211>  2831
<212>  DNA
<213>  Homosapiens

<400>  7989
ttaggtttct gaaactgatg aaaaagaaga cctgctgcat gaaaaccgct tgatgcaaga     60

tgaaattgcc aggctcaggc tggaaaaaga cacaataaaa aaccaaaacc tggaaaagaa    120

atacttaaaa gactttgaaa ttgtgaaaag aaagcatgaa gaccttcaaa aggctctaaa    180

acggaatggg gaaacattag caaaaacgat agcctgttat agtggacagc ttgctgctct    240

gacagatgaa aacacaacgc tccgttccaa actggagaag caaagagaga gcaggcaaag    300

actggaaaca gaaatgcaat cataccattg tagactgaat gctgctcgat gtgatcatga    360

tcaaagtcac tcatcaaaaa gagaccaaga gcttgctttc cagggcacag tagataaatg    420

tcgtcactta caggaaaatt tgaattctca tgttctgatt ctttctctgc aactttctaa    480

agctgagagt aagtccagag tcctcaaaac tgagctccat tacacaggag aggctctgaa    540

agaaaaggct ttggtttttg aacacgtgca aagtgagcta aagcaaaaac agagtcaaat    600

gaaggacatt gaaaaaatgt acaaaagtgg atacaataca atggaaaaat gcatagaaaa    660

acaggaaaga ttttgtcaac taaaaaaaca aaatatgttg cttcaacagc aactggatga    720

tgctcgcaac aaagctgaca atcaagaaaa agcaatactt aatattcaag ccagatgtga    780

tgctagagta caaaaccttc aagctgagtg cagaaagcac cgtcttttac tagaagaaga    840

caataaaatg ttggtcaatg aactgaatca ttcgaaagaa aaagaatgcc aatatgaaaa    900

agagaaagca gaaagagaag tagctgtgag acagcttcaa caaaaacgag atgatgtctt    960

aaacaaagga tcagcaacaa aagctctgct ggatgcttca tcgcgtcact gcacctattt   1020

agaaaatggg atgcaggatt caaggaagaa attagaccag atgagaagtc aagcttgaag   1080

tagaacatgt gatgatgaga aaaattatta aaaaacagga tgaccaaatt gagcggcttg   1140

agaaaatcct gcagcattca agtttgatgc tgcaggtgtt tgagagctag atgaagcatc   1200

cagccaaact agactacatg gagctccaca gtgatcgtct tcacctccag ctgtttgcat   1260

ttacttcttc cctctatcct acatgtgttt tccttcccct tcagatatca acctatgaat   1320

tgcctctacc aaaaagccta caatattgac acaaacctgg gctagtatcc cttctatgtc   1380

ttccaataag tgctgtctta tgcttgtcat tgtatgtatg actctgtatg ggaattgcct   1440

gtttgttttt tcagattata gcatacagtt gttgaggggc ggaccgtatc atctttatct   1500

tgtaattcca gtgcttgtcc tagtacctta gcacatggtt gctgaataca tgaacgaaga   1560

gtgagaaacc agaagctctg atacttaact gccatgataa tgaattcggt gtgcaactat   1620

gggcaaatta tatttaatag taattgcata ttgtacatat ttttcattct tattaacact   1680

gataagcttt tcagcatata ctgactttct cttagttaac tgtgaaatca tttagataaa   1740

gaatataatt ctttttcatt ctaacttctg aatttaaatc tgaatcctct atagcagggg   1800

tccccaactc ccaggccaca cacagttcca tgacctgtta ggaagcaggc tgcacagcag   1860

gaggtgagtg gcaggcaagc gagtgaagct tcatctgtat ttccagccac tccctgttgc   1920

tcacattatc acctgagctc tgcctcctgt cagatcagca aagccattag attctcacag   1980

gagtgaaaat cctactgtga actgctcgtt caagggatct aggtcacatg ctccttatga   2040

gactctaatg cctgatgata tgtcattgtc tcctatctct tcacgatggg accatctagt   2100

tacagaaaaa caagctcagg actcccattg attctccatt atgatgagtt gtgtaattat   2160

ttcattatgt attacaatgt agtcataata ggaataaagt gcacaataga tgtaatacgc   2220

ttgaatcacc atcctgaaac catcccccaa acccccatct gtggaaaaat tatctttcac   2280

aaaactgctg cctggtgcca aaaaggctgg ggactgctgc tctatagctt ctgcactaga   2340

atctactaat gagtaaaatt taaatcaata actagtttta aaagcataac aagaatatgt   2400

gctgtctggc tgcagtggct catgcctgta ttctcagcac tttgggaggc cagtgcaggt   2460

ggatcacttg aggtcaggag ttcaagacca gcctggccaa tatggtgaaa tcctgtctct   2520

actaaaaata caaaaattag ctgggtgtgg tggtgcatgc ctgtagtctc agctactcgg   2580

gaggctgagg tgggagaatc acttgaaccc gggaggcaga ggtttcagtg agccaagatc   2640

gtgccactgc actccagcct gagcaacaga gtgactccat ctcaaatgca aaacaaaaca   2700

gaaagaatac atgctgacga aaaaaatcta agacaataaa attgtattac taggctgtta   2760

acatgatatt ttgtttcccg ttaaatgtgt gacatgcaaa agtatttatt aaatgaaaat   2820

attttttatc t                                                        2831


<210>  7990
<211>  341
<212>  PRT
<213>  Homosapiens

<400>  7990

Met Gln Asp Glu Ile Ala Arg Leu Arg Leu Glu Lys Asp Thr Ile Lys 
1               5                   10                  15      


Asn Gln Asn Leu Glu Lys Lys Tyr Leu Lys Asp Phe Glu Ile Val Lys 
            20                  25                  30          


Arg Lys His Glu Asp Leu Gln Lys Ala Leu Lys Arg Asn Gly Glu Thr 
        35                  40                  45              


Leu Ala Lys Thr Ile Ala Cys Tyr Ser Gly Gln Leu Ala Ala Leu Thr 
    50                  55                  60                  


Asp Glu Asn Thr Thr Leu Arg Ser Lys Leu Glu Lys Gln Arg Glu Ser 
65                  70                  75                  80  


Arg Gln Arg Leu Glu Thr Glu Met Gln Ser Tyr His Cys Arg Leu Asn 
                85                  90                  95      


Ala Ala Arg Cys Asp His Asp Gln Ser His Ser Ser Lys Arg Asp Gln 
            100                 105                 110         


Glu Leu Ala Phe Gln Gly Thr Val Asp Lys Cys Arg His Leu Gln Glu 
        115                 120                 125             


Asn Leu Asn Ser His Val Leu Ile Leu Ser Leu Gln Leu Ser Lys Ala 
    130                 135                 140                 


Glu Ser Lys Ser Arg Val Leu Lys Thr Glu Leu His Tyr Thr Gly Glu 
145                 150                 155                 160 


Ala Leu Lys Glu Lys Ala Leu Val Phe Glu His Val Gln Ser Glu Leu 
                165                 170                 175     


Lys Gln Lys Gln Ser Gln Met Lys Asp Ile Glu Lys Met Tyr Lys Ser 
            180                 185                 190         


Gly Tyr Asn Thr Met Glu Lys Cys Ile Glu Lys Gln Glu Arg Phe Cys 
        195                 200                 205             


Gln Leu Lys Lys Gln Asn Met Leu Leu Gln Gln Gln Leu Asp Asp Ala 
    210                 215                 220                 


Arg Asn Lys Ala Asp Asn Gln Glu Lys Ala Ile Leu Asn Ile Gln Ala 
225                 230                 235                 240 


Arg Cys Asp Ala Arg Val Gln Asn Leu Gln Ala Glu Cys Arg Lys His 
                245                 250                 255     


Arg Leu Leu Leu Glu Glu Asp Asn Lys Met Leu Val Asn Glu Leu Asn 
            260                 265                 270         


His Ser Lys Glu Lys Glu Cys Gln Tyr Glu Lys Glu Lys Ala Glu Arg 
        275                 280                 285             


Glu Val Ala Val Arg Gln Leu Gln Gln Lys Arg Asp Asp Val Leu Asn 
    290                 295                 300                 


Lys Gly Ser Ala Thr Lys Ala Leu Leu Asp Ala Ser Ser Arg His Cys 
305                 310                 315                 320 


Thr Tyr Leu Glu Asn Gly Met Gln Asp Ser Arg Lys Lys Leu Asp Gln 
                325                 330                 335     


Met Arg Ser Gln Ala 
            340     


<210>  7991
<211>  853
<212>  DNA
<213>  Homosapiens

<400>  7991
actcggccct gcaattacag cacaaaagta gccatgaaca atatgcagac tgaaggggtg     60

tagcagtgtc ccactaaaat tacttacaaa aaacaggtaa tgggatgatt tctcctagat    120

tatgaccttt tataaataaa aaagattgtg atagtctaaa atatttcata tatattttgt    180

tgattcattc atctactgat ggacatttag gtcatttcca aatgtaattt tttaaaattc    240

tttgtttcag tttcaagaaa tacaggatca acttacagct actataagat gtactaagga    300

gatggaaggc gacacacaaa agtaaaattt gaagcagcac acaaaataac ttgagtattt    360

ataaagcaaa agagcactgt agtatgaaaa ttgtatcagt tatgataatt agtatgtctt    420

tgtgaagcca aaaaagtttc atttgtaagc tatatcgaaa tacatcattt ttctacatta    480

ttcctaaatt ttgcatatta tcaccaaaac acaggtagaa aatgacacag tagcccaatc    540

gtctactttt gtgattgcta agaatttgtg taattatacc ttcagaagtt tgtttagaat    600

ttacatgatt taaaaaaaat tacgtgtgag agtaattatt ttaaaatgca cattttaggc    660

ttgaagtaga acatgtgatg atgagaaaaa ttattaaaaa acaggatgac caaattgagc    720

ggcttgagaa aatcctgcag cattcaagtt tgatgctgca ggtgtttgag agctagatga    780

aggtatgttg ccaaaattta tgaattaaat tcaaatcatt gatttctgaa ataaactcta    840

agtagtgaac ggt                                                       853


<210>  7992
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  7992

Met Met Arg Lys Ile Ile Lys Lys Gln Asp Asp Gln Ile Glu Arg Leu 
1               5                   10                  15      


Glu Lys Ile Leu Gln His Ser Ser Leu Met Leu Gln Val Phe Glu Ser 
            20                  25                  30          


<210>  7993
<211>  576
<212>  DNA
<213>  Homosapiens

<400>  7993
tttgagcaag atcttaaaga aaatcagatg ccttcacctg accactgctt ggtgatccca     60

tggcactttg tacatctctc cattagctct catctcacca gcccatcatt attgtatgtg    120

ctgccttctg aagcttgcag ctggctacat cagtccaatg tgaataacaa aatgaagaat    180

atcaggatga ttcgagacca ggaatactac agatgtccaa cacttccacc tggaatcccc    240

aaagaggccc gcttttagcc tccacactgg ttggtgacct gacatgagag aaatgacaga    300

aatctcagaa gactggcctc atgaataatc ttcagtttca atgtaacaaa gcaagccttc    360

tagaaattac ctgcctctgc agttcactct gctgcttcag atgaaaattt tcagagttcc    420

accacccctg gagaatacag caactgttta ctgcaatcag caatcaggat ggagaattcg    480

tgctgtgggg gccaatccag gggttccctg tcatgagcag tggggagtgt gtagaaccca    540

tgagagatgg gctttggtca attaaagctt gttgaa                              576


<210>  7994
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  7994

Met Pro Ser Pro Asp His Cys Leu Val Ile Pro Trp His Phe Val His 
1               5                   10                  15      


Leu Ser Ile Ser Ser His Leu Thr Ser Pro Ser Leu Leu Tyr Val Leu 
            20                  25                  30          


Pro Ser Glu Ala Cys Ser Trp Leu His Gln Ser Asn Val Asn Asn Lys 
        35                  40                  45              


Met Lys Asn Ile Arg Met Ile Arg Asp Gln Glu Tyr Tyr Arg Cys Pro 
    50                  55                  60                  


Thr Leu Pro Pro Gly Ile Pro Lys Glu Ala Arg Phe 
65                  70                  75      


<210>  7995
<211>  787
<212>  DNA
<213>  Homosapiens

<400>  7995
atcccacatc aaaaagttag gaagaactca aattaataac ctaacatcac aactgaaaga     60

actagagaag caagacaaaa ccccaaagct agaggaagac aagaaataac tgaaaatctg    120

agctgaactg aaagaaaccg agacatgaaa aaaagaaatt caaaagatct atgaattccg    180

ggtgatggca tcagctgaga agggaaggaa gcccatgaga ggacactgaa gaaggagtga    240

gcagacaata agaagcccac agaagacaga gaaggaacaa ctagagggag aagccaaggc    300

aggcgtgtgt gtttctccac agacactacc caaagcagtg cttcactaca gtggcagaca    360

gacctgaaaa ttttcatctg aagcagcaga gtgaactgca gaggcaggtc accaaccagt    420

gtggaggcta aaagcgggcc tctttgggga ttccaggtgg aagtgttgga catctgtagt    480

attcctggtc tcgaatcatc ctgatattct tcattttgtt attcacattg gactaggaga    540

tagaatctca ctatgttgac caggctggtc ttgaactctt ggcacccaag cgatcctttt    600

gcctggaatc ccaaagtgtc agatttactg aagaatattt cattgtaatt actttttata    660

ctttataggt caagagctct gttttaaata caaaatttat tgaatatact ttttcaaaca    720

aagtttcatg ttctaatcat tgtctgattt cagcattaaa tgaaacacag taaagaaagt    780

tgggctg                                                              787


<210>  7996
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  7996

Met Leu Thr Arg Leu Val Leu Asn Ser Trp His Pro Ser Asp Pro Phe 
1               5                   10                  15      


Ala Trp Asn Pro Lys Val Ser Asp Leu Leu Lys Asn Ile Ser Leu 
            20                  25                  30      


<210>  7997
<211>  576
<212>  DNA
<213>  Homosapiens

<400>  7997
aagttaggaa gaactcaaat taataaccta acatcacaac tgaaagaact agagaagcaa     60

gacaaaaccc caaagctaga ggaagacaag aaataactga aaatctgagc tgaactgaaa    120

gaaaccgaga catgaaaaaa agaaattcaa aagatctatg aattccggtt tctccacaga    180

cactacccaa agcagtgctt cactacagtg gcagacagac ctgaaaattt tcatctgaag    240

cagcagagtg aactgcagag gcaggtcacc aaccagtgtg gaggctaaaa gcgggcctct    300

ttggggattc caggtggaag tgttggacat ctgtagtatt cctggtctcg aatcatcctg    360

atattcttca ttttgttatt cacattggac taggagatag aatctcacta tgttgaccag    420

gctggtcttg aactcttggc acccaagcga tccttttgcc tggaatccca aagtgtcaga    480

tttactgaag aatatttcat tgtaattact ttttatactt tataggtcaa gagctctgtt    540

ttaaatacaa aatttattga atatactttt tcaaac                              576


<210>  7998
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  7998

Met Leu Thr Arg Leu Val Leu Asn Ser Trp His Pro Ser Asp Pro Phe 
1               5                   10                  15      


Ala Trp Asn Pro Lys Val Ser Asp Leu Leu Lys Asn Ile Ser Leu 
            20                  25                  30      


<210>  7999
<211>  2192
<212>  DNA
<213>  Homosapiens

<400>  7999
gatctttcac ctccctggtt agctgtattc ctaggtatct tattttttct gtgtgtagca     60

attatgaatg ggattgtgtt cttcatttga ctctctgctt gacttgatgt ataggactgc    120

tagtaatttt tgcacattga ttttgtatgc taagactttg ctaaagttta tcagcagaag    180

aagctttggg gccaagacta tggggctttc tagatataga aacatgtcat ctgtaaacag    240

agacagtttg acttcctgtc tattcctctc ttccctcctc tgtttggatg cccttccagt    300

tttgcacatt cagtgtaatg ttggctgtgg gtttgtcatg gctagctctc atcattttgg    360

cacttctgac tagaagggca agaggggcca gtgttgttgt tacctgaaag gtaagtgcag    420

cccacaaaaa tgcagtgaag aagaagatgt attatgcata tgtttaagtt aatacaattg    480

agatatattt agcagacaga atcaatagag ttgatgagtg actgactgga tgtgtgggga    540

gtttatatca ctcccaggtt tttgacttgg gcaaccgggc actcatgaag gaaaaagggg    600

atccagggag aggaactttt ctgaggactg gggtagggct gaacagctgc attcgaggct    660

ggtggagggt gggctgggca tgggatgcac aaatggaaat tccactgggt ctgcagctca    720

cacataggca tgaccagcat agagatagag aggccccagt gctgctgagt aactgtgatt    780

ccccaggtga tggcatcagc tgagaaggga aggaagccca tgagaggaca ctgaagaagg    840

agtgagcaga caataagaag cccacagaag acagagaagg aacaactaga gggagaagcc    900

aaggcaggcg tgtgtggtaa cacataggaa ctgagggaga ggacatttca agatggtggg    960

gatgccatac aacaggacta tgtgatggtt tttggctgtg tccataggaa gtcacaacag   1020

gcaagggaaa gaaaccagaa cccagtcatg gagttaagaa gtgagtcaga gagtagatgg   1080

gtagggacag tgaggtaagg cctctttcta aggaagtttg gctgaaggat agactagctg   1140

gacacatgct ggctgtgtgg ggtagaggga ggaatgatgg agggtaggag agccttgagc   1200

ctgcgagaag agtctcttag aatagagaag ctgaagttaa agttgtggaa gagagtgggg   1260

ataactgagt gacagataat caggagaaga aaaggagatc cagactcatg acagagagat   1320

gacctttgcc aagagcacag ccgtctttca cggtcacaga gaggtaggac aaaatgagtg   1380

gtgttcaaga attggtttgt agcacaatat ttcaactatg tcctttaaaa agtttctcca   1440

cagacactac ccaaagcagt gcttcactac agtggcagac agacctgaaa attttcatct   1500

gaagcagcag agtgaactgc agaggcaggt caccaaccag tgtggaggct aaaagcgggc   1560

ctctttgggg attccaggtg gaagtgttgg acatctgtag tattcctggt ctcgaatcat   1620

cctgatattc ttcattttgt tattcacatt ggactaggca ggaacaaaga tcaccacaac   1680

tggctcccct tcaactatgt tagatggcaa cttgccttca gtatggtgaa acacatcagt   1740

taagaccggg gttgtgcatg gcaggacttt ctacaaggac acccagtctc cttaataaac   1800

atgagatgct ctctttccag aatttctctt gcctgacaca gcataggaag atgctgaacg   1860

gccacacagt gatccattgg tcagtggtga cataaggagg tcagagggga ggagtgagga   1920

gaagtaggga agactaggtg gttgtaggcc tccttcatct gttcattggc tgtggcatta   1980

ggccagctac tctttgcact tctgtaaagt gagacggtcg atcttgtctg cctctctaga   2040

ggatggttgc aggtgtcaaa tggggtagtt aggtgggagg gcatttcaca aagttaaaaa   2100

atatgacttt ggaggcttgt tatattgatg aggattataa tccctgagaa ttcctggtat   2160

gaagaaggga aaagaagata atttgtgaaa ga                                 2192


<210>  8000
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  8000

Met Ser Phe Lys Lys Phe Leu His Arg His Tyr Pro Lys Gln Cys Phe 
1               5                   10                  15      


Thr Thr Val Ala Asp Arg Pro Glu Asn Phe His Leu Lys Gln Gln Ser 
            20                  25                  30          


Glu Leu Gln Arg Gln Val Thr Asn Gln Cys Gly Gly 
        35                  40                  


<210>  8001
<211>  715
<212>  DNA
<213>  Homosapiens

<400>  8001
gcatgggatg cacaaatgga aattccactg ggtctgcagc tcacacatag gcatgaccag     60

catagagata gagaggcccc agtgctgctg agtaactgtg attccccagg tgatggcatc    120

agctgagaag ggaaggaagc ccatgagagg acactgaaga aggagtgagc agacaataag    180

aagcccacag aagacagaga aggaacaact agagggagaa gccaaggcag gcgtgtgtgt    240

ttctccacag acactaccca aagcagtgct tcactacagt ggcagacaga cctgaaaatt    300

ttcatctgaa gcagcagagt gaactgcaga ggcaggtcac caaccagtgt ggaggctaaa    360

agcgggcctc tttggggatt ccaggtggaa gtgttggaca tctgtagtat tcctggtctc    420

gaatcatcct gatattcttc attttgttat tcacattgga ctaggagata gaatctcact    480

atgttgacca ggctggtctt gaactcttgg cacccaagcg atccttttgc ctggaatccc    540

aaagtgtcag atttactgaa gaatatttca ttgtaattac tttttatact ttataggtca    600

agagctctgt tttaaataca aaatttattg aatatacttt ttcaaacaaa gtttcatgtt    660

ctaatcattg tctgatttca gcattaaatg aaacacagta aagaaagttg ggctg         715


<210>  8002
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  8002

Met Glu Ile Pro Leu Gly Leu Gln Leu Thr His Arg His Asp Gln His 
1               5                   10                  15      


Arg Asp Arg Glu Ala Pro Val Leu Leu Ser Asn Cys Asp Ser Pro Gly 
            20                  25                  30          


Asp Gly Ile Ser 
        35      


<210>  8003
<211>  863
<212>  DNA
<213>  Homosapiens

<400>  8003
aagcccatga gaggacactg aagaaggagt gagcagacaa taagaagccc acagaagaca     60

gagaaggaac aactagaggg agaagccaag gcaggcgtgt gtgtttctcc acagacacta    120

cccaaagcag tgcttcacta cagtggcaga cagacctgaa aattttcatc tgaagcagca    180

gagtgaactg cagaggcagg tcaccaacca gtgtggaggc taaaagcggg cctctttggg    240

gattccaggt ggaagtgttg gacatctgta gtattcctgg tctcgaatca tcctgatatt    300

cttcattttg ttattcacat tggactaggc aggaacaaag atcaccacaa ctggctcccc    360

ttcaactatg ttagatggca acttgccttc agtatggtga aacacatcag ttaagaccgg    420

ggttgtgcat ggcaggactt tctacaagga cacccagtct ccttaataaa catgagatgc    480

tctctttcca gaatttctct tgcctgacac agcataggaa gatgctgaac ggccacacag    540

tgatccattg gtcagtggtg acataaggag gtcagagggg aggagtgagg agaagtaggg    600

aagactaggt ggttgtaggc ctccttcatc tgttcattgg ctgtggcatt aggccagcta    660

ctctttgcac ttctgtaaag tgagacggtc gatcttgtct gcctctctag aggatggttg    720

caggtgtcaa atggggtagt taggtgggag ggcatttcac aaagttaaaa aatatgactt    780

tggaggcttg ttatattgat gaggattata atccctgaga attcctggta tgaagaaggg    840

aaaagaagat aatttgtgaa aga                                            863


<210>  8004
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  8004

Met Ala Thr Cys Leu Gln Tyr Gly Glu Thr His Gln Leu Arg Pro Gly 
1               5                   10                  15      


Leu Cys Met Ala Gly Leu Ser Thr Arg Thr Pro Ser Leu Leu Asn Lys 
            20                  25                  30          


His Glu Met Leu Ser Phe Gln Asn Phe Ser Cys Leu Thr Gln His Arg 
        35                  40                  45              


Lys Met Leu Asn Gly His Thr Val Ile His Trp Ser Val Val Thr 
    50                  55                  60              


<210>  8005
<211>  842
<212>  DNA
<213>  Homosapiens

<400>  8005
cagagagtag atgggtaggg acagtgaggt aaggcctctt tctaaggaag tttggctgaa     60

ggatagacta gctggacaca tgctggctgt gtggggtaga gggaggaatg atggagggta    120

ggagagcctt gagcctgcga gaagagtctc ttagaataga gaagctgaag ttaaagttgt    180

ggaagagagt ggggataact gagtgacaga taatcaggag aagaaaagga gatccagact    240

catgacagag agatgacctt tgccaagagc acagccgtct ttcacggtca cagagaggta    300

ggacaaaatg agtggtgttc aagaattggt ttgtagcaca atatttcaac tatgtccttt    360

aaaaagtttc tccacagaca ctacccaaag cagtgcttca ctacagtggc agacagacct    420

gaaaattttc atctgaagca gcagagtgaa ctgcagaggc aggtcaccaa ccagtgtgga    480

ggctaaaagc gggcctcttt ggggattcca ggtggaagtg ttggacatct gtagtattcc    540

tggtctcgaa tcatcctgat attcttcatt ttgttattca cattggacta ggagatagaa    600

tctcactatg ttgaccaggc tggtcttgaa ctcttggcac ccaagcgatc cttttgcctg    660

gaatcccaaa gtgtcagatt tactgaagaa tatttcattg taattacttt ttatacttta    720

taggtcaaga gctctgtttt aaatacaaaa tttattgaat atactttttc aaacaaagtt    780

tcatgttcta atcattgtct gatttcagca ttaaatgaaa cacagtaaag aaagttgggc    840

tg                                                                   842


<210>  8006
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  8006

Met Ser Phe Lys Lys Phe Leu His Arg His Tyr Pro Lys Gln Cys Phe 
1               5                   10                  15      


Thr Thr Val Ala Asp Arg Pro Glu Asn Phe His Leu Lys Gln Gln Ser 
            20                  25                  30          


Glu Leu Gln Arg Gln Val Thr Asn Gln Cys Gly Gly 
        35                  40                  


<210>  8007
<211>  931
<212>  DNA
<213>  Homosapiens

<400>  8007
cagagagtag atgggtaggg acagtgaggt aaggcctctt tctaaggaag tttggctgaa     60

ggatagacta gctggacaca tgctggctgt gtggggtaga gggaggaatg atggagggta    120

ggagagcctt gagcctgcga gaagagtctc ttagaataga gaagctgaag ttaaagttgt    180

ggaagagagt ggggataact gagtgacaga taatcaggag aagaaaagga gatccagact    240

catgacagag agatgacctt tgccaagagc acagccgtct ttcacggtca cagagaggta    300

ggacaaaatg agtggtgttc aagaattggt ttgtagcaca atatttcaac tatgtccttt    360

aaaaagtttc tccacagaca ctacccaaag cagtgcttca ctacagtggc agacagacct    420

gaaaattttc atctgaagca gcagagtgaa ctgcagaggc aggtcaccaa ccagtgtgga    480

ggctaaaagc gggcctcttt ggggattcca ggtggaagtg ttggacatct gtagtattcc    540

tggtctcgaa tcatcctgat attcttcatt ttgttattca cattggacta ggagatagaa    600

tctcactatg ttgaccaggc tggtcttgaa ctcttggcac ccaagcgatc cttttgcctg    660

gaatcccaaa gtgtcagatt tactgaagaa tatttcattg taattacttt ttatacttta    720

taggtcaaga gctctgtttt aaatacaaaa tttattgaat atactttttc aaacaaagtt    780

tcatgttcta atcattgtct gatttcagca ttaaatgaaa cacagtaaag aaagttgggc    840

tgatgttgtt gttggtggtt gtttttgtat tctgattaca gaactgtatt ttgagtgggc    900

tgaacataga gtaaatgcat cctcagctgc t                                   931


<210>  8008
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  8008

Met Ser Phe Lys Lys Phe Leu His Arg His Tyr Pro Lys Gln Cys Phe 
1               5                   10                  15      


Thr Thr Val Ala Asp Arg Pro Glu Asn Phe His Leu Lys Gln Gln Ser 
            20                  25                  30          


Glu Leu Gln Arg Gln Val Thr Asn Gln Cys Gly Gly 
        35                  40                  


<210>  8009
<211>  565
<212>  DNA
<213>  Homosapiens

<400>  8009
tttctccaca gacactaccc aaagcagtgc ttcactacag tggcagacag acctgaaaat     60

tttcatctga agcagcagag tgaactgcag aggcaggtca ccaaccagtg tggaggctaa    120

aagcgggcct ctttggggat tccaggtgga agtgttggac atctgtagta ttcctggtct    180

cgaatcatcc tgatattctt cattttgtta ttcacattgg actaggagat agaatctcac    240

tatgttgacc aggctggtct tgaactcttg gcacccaagc gatccttttg cctggaatcc    300

caaagtgtca gatttactga agaatatttc attgtaatta ctttttatac tttataggtc    360

aagagctctg ttttaaatac aaaatttatt gaatatactt tttcaaacaa agtttcatgt    420

tctaatcatt gtctgatttc agcattaaat gaaacacagt aaagaaagtt gggctgatgt    480

tgttgttggt ggttgttttt gtattctgat tacagaactg tattttgagt gggctgaaca    540

tagagtaaat gcatcctcag ctgct                                          565


<210>  8010
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  8010

Met Lys His Ser Lys Glu Ser Trp Ala Asp Val Val Val Gly Gly Cys 
1               5                   10                  15      


Phe Cys Ile Leu Ile Thr Glu Leu Tyr Phe Glu Trp Ala Glu His Arg 
            20                  25                  30          


Val Asn Ala Ser Ser Ala 
        35              


<210>  8011
<211>  444
<212>  DNA
<213>  Homosapiens

<400>  8011
ttcaactatg ttagatggca acttgccttc agtatggtga aacacatcag ttaagaccgg     60

ggttgtgcat ggcaggactt tctacaagga cacccagtct ccttaataaa catgagatgc    120

tctctttcca gaatttctct tgcctgacac agcataggaa gatgctgaac ggccacacag    180

tgatccattg agatagaatc tcactatgtt gaccaggctg gtcttgaact cttggcaccc    240

aagcgatcct tttgcctgga atcccaaagt gtcagattta ctgaagaata tttcattgta    300

attacttttt atactttata ggtcaagagc tctgttttaa atacaaaatt tattgaatat    360

actttttcaa acaaagtttc atgttctaat cattgtctga tttcagcatt aaatgaaaca    420

cagtaaagaa agttgggctg atgt                                           444


<210>  8012
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  8012

Met Ala Thr Cys Leu Gln Tyr Gly Glu Thr His Gln Leu Arg Pro Gly 
1               5                   10                  15      


Leu Cys Met Ala Gly Leu Ser Thr Arg Thr Pro Ser Leu Leu Asn Lys 
            20                  25                  30          


His Glu Met Leu Ser Phe Gln Asn Phe Ser Cys Leu Thr Gln His Arg 
        35                  40                  45              


Lys Met Leu Asn Gly His Thr Val Ile His 
    50                  55              


<210>  8013
<211>  722
<212>  DNA
<213>  Homosapiens

<400>  8013
acattctcct cgcccttaga tccagaagca gcagttttcc tggaccctcc aagatgcgct     60

tcctggccct gctcgtctgc ctcctggtgc tgggctttca aggaaactca tcctcctgct    120

gagaggaaga cgttgcagcc tcctcagcct ccatggtgtt gatggtgaca gtgaaatgag    180

ttccagatcc agggagatgg aaccagggat ttcaccatca caaacactac tttggagcct    240

ggagatgctg cacatcctcc tgtgagcaga acactcactg ggaccctgca cagtgtgatg    300

gccccaaaca taaagctctc aaggaagctc cgcctctcag cgtggaagga gaggctgcgg    360

tgccagggga tgtgtccaca gagagtcgag tcaggtgggc tcaggcagtt gcctggagag    420

tctttgagga agaggacatg aggcctcagt cacaggatcc agtggtgata ctgtgatggc    480

ccagactcca ctctcctggc ctgtcgcctc tagagagcca cccccatatc ctgtaggtct    540

agtcagagcc tcttgtccag tgatggatac acctattcgt attggttcct gcagaagcca    600

ggccagtctc cacagctcct gatctatttt gtttcaaacc gggcctctgg agtcccagac    660

aggttcaatg gcagtgggtc aggcactgat ttcacactga aaatcagccg ggtggagctg    720

aa                                                                   722


<210>  8014
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  8014

Met Ala Gln Thr Pro Leu Ser Trp Pro Val Ala Ser Arg Glu Pro Pro 
1               5                   10                  15      


Pro Tyr Pro Val Gly Leu Val Arg Ala Ser Cys Pro Val Met Asp Thr 
            20                  25                  30          


Pro Ile Arg Ile Gly Ser Cys Arg Ser Gln Ala Ser Leu His Ser Ser 
        35                  40                  45              


<210>  8015
<211>  565
<212>  DNA
<213>  Homosapiens

<400>  8015
tttctccaca gacactaccc aaagcagtgc ttcactacag tggcagacag acctgaaaat     60

tttcatctga agcagcagag tgaactgcag aggcaggtca ccaaccagtg tggaggctaa    120

aagcgggcct ctttggggat tccaggtgga agtgttggac atctgtagta ttcctggtct    180

cgaatcatcc tgatattctt cattttgtta ttcacattgg actaggagat agaatctcac    240

tatgttgacc aggctggtct tgaactcttg gcacccaagc gatccttttg cctggaatcc    300

caaagtgtca gatttactga agaatatttc attgtaatta ctttttatac tttataggtc    360

aagagctctg ttttaaatac aaaatttatt gaatatactt tttcaaacaa agtttcatgt    420

tctaatcatt gtctgatttc agcattaaat gaaacacagt aaagaaagtt gggctgatgt    480

tgttgttggt ggttgttttt gtattctgat tacagaactg tattttgagt gggctgaaca    540

tagagtaaat gcatcctcag ctgct                                          565


<210>  8016
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  8016

Met Lys His Ser Lys Glu Ser Trp Ala Asp Val Val Val Gly Gly Cys 
1               5                   10                  15      


Phe Cys Ile Leu Ile Thr Glu Leu Tyr Phe Glu Trp Ala Glu His Arg 
            20                  25                  30          


Val Asn Ala Ser Ser Ala 
        35              


<210>  8017
<211>  1927
<212>  DNA
<213>  Homosapiens

<400>  8017
ggattgtgtt cttcatttga ctctctgctt gacttgatgt ataggactgc tagtaatttt     60

tgcacattga ttttgtatgc taagactttg ctaaagttta tcagcagaag aagctttggg    120

gccaagacta tggggctttc tagatataga aacatgtcat ctgtaaacag agacagtttg    180

acttcctgtc tattcctctc ttccctcctc tgtttggatg cccttccagt tttgcacatt    240

cagtgtaatg ttggctgtgg gtttgtcatg gctagctctc atcattttgg cacttctgac    300

tagaagggca agaggggcca gtgttgttgt tacctgaaag gtaagtgcag cccacaaaaa    360

tgcagtgaag aagaagatgt attatgcata tgtttaagtt aatacaattg agatatattt    420

agcagacaga atcaatagag ttgatgagtg actgactgga tgtgtgggga gtttatatca    480

ctcccaggtt tttgacttgg gcaaccgggc actcatgaag gaaaaagagg atccagggag    540

aggaactttt ctgaggactg gggtagggct gaacagctgc attcgaggct ggtggagggt    600

gggctgggca tgggatgcac aaatggaaat tccactgggt ctgcagctca cacataggca    660

tgaccagcat agagatagag aggccccagt gctgctgagt aactgtgatt ccccaggtga    720

tggcatcagc tgagaaggga aggaagccca tgagaggaca ctgaagaagg agtgagcaga    780

caataagaag cccacagaag acagagaagg aacaactaga gggagaagcc aaggcaggcg    840

tgtgtggtaa cacataggaa ctgagggaga ggacatttca agatggtggg gatgccatac    900

aacaggacta tgtgatgatt tttggctgtg tccataggaa gtcacaacag gcaagggaaa    960

gaaaccagaa cccagtcatg gagctaagaa gtgagtcaga gagtagaggg gtagggacag   1020

tgaggtaagt cctctttcta aggaagtttg gctgaaggat agactagctg gacacatgct   1080

ggctgtgtgg ggtagaggga ggaatgatgg agggtaggag agccttgagc ctgcgagaag   1140

agtctcttag aatagagaag ctgaagttaa agttgtggaa gagagtgggg ataactgagt   1200

gacagataat caggagaaga aaaggagatc cagactcatg acagagagat gacctttgcc   1260

aagagtacag ccgtctttca cggtcacaga gaggtaggac aaaatgagtg gtgttcaaga   1320

attggtttgt agcacaatat ttcaactatg tcctttaaaa agtttctcca cagacactac   1380

ccaaagcagt gcttcactac agtggcagac agacctgaaa attttcatct gaagcagcag   1440

agtgaactgc agaggcaggt caccaaccag tgtggaggct aaaagcgggc ctctttgggg   1500

attccaggtg gaagtgttgg acatctgtag tattcctggt ctcgaatcat cctgatattc   1560

ttcattttgt tattcacatt ggactaggag atagaatctc actatgttga ccaggctggt   1620

cttgaactct tggcacccaa gcgatccttt tgcctggaat cccaaagtgt cagatttact   1680

gaagaatatt tcattgtaat tactttttat actttatagg tcaagagctc tgttttaaat   1740

acaaaattta ttgaatatac tttttcaaac aaagtttcat gttctaatca ttgtctgatt   1800

tcagcattaa atgaaacaca gtaaagaaag ttgggctgat gttgttgttg gtggttgttt   1860

ttgtattctg attacagaac tgtattttga gtgggctgaa catagagtaa atgcatcctc   1920

agctgct                                                             1927


<210>  8018
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  8018

Met Ser Phe Lys Lys Phe Leu His Arg His Tyr Pro Lys Gln Cys Phe 
1               5                   10                  15      


Thr Thr Val Ala Asp Arg Pro Glu Asn Phe His Leu Lys Gln Gln Ser 
            20                  25                  30          


Glu Leu Gln Arg Gln Val Thr Asn Gln Cys Gly Gly 
        35                  40                  


<210>  8019
<211>  1625
<212>  DNA
<213>  Homosapiens

<400>  8019
ggattgtgtt cttcatttga ctctctgctt gacttgatgt ataggactgc tagtaatttt     60

tgcacattga ttttgtatgc taagactttg ctaaagttta tcagcagaag aagctttggg    120

gccaagacta tggggctttc tagatataga aacatgtcat ctgtaaacag agacagtttg    180

acttcctgtc tattcctctc ttccctcctc tgtttggatg cccttccagt tttgcacatt    240

cagtgtaatg ttggctgtgg gtttgtcatg gctagctctc atcattttgg cacttctgac    300

tagaagggca agaggggcca gtgttgttgt tacctgaaag gtaagtgcag cccacaaaaa    360

tgcagtgaag aagaagatgt attatgcata tgtttaagtt aatacaattg agatatattt    420

agcagacaga atcaatagag ttgatgagtg actgactgga tgtgtgggga gtttatatca    480

ctcccaggtt tttgacttgg gcaaccgggc actcatgaag gaaaaagagg atccagggag    540

aggaactttt ctgaggactg gggtagggct gaacagctgc attcgaggct ggtggagggt    600

gggctgggca tgggatgcac aaatggaaat tccactgggt ctgcagctca cacataggca    660

tgaccagcat agagatagag aggccccagt gctgctgagt aactgtgatt ccccaggtga    720

tggcatcagc tgagaaggga aggaagccca tgagaggaca ctgaagaagg agtgagcaga    780

caataagaag cccacagaag acagagaagg aacaactaga gggagaagcc aaggcaggcg    840

tgtgtgtttc tccacagaca ctacccaaag cagtgcttca ctacagtggc agacagacct    900

gaaaattttc atctgaagca gcagagtgaa ctgcagaggc aggtcaccaa ccagtgtgga    960

ggctaaaagc gggcctcttt ggggattcca ggtggaagtg ttggacatct gtagtattcc   1020

tggtctcgaa tcatcctgat attcttcatt ttgttattca cattggacta ggcaggaaca   1080

aagatcacca caactggctc gccttcaact atgttagatg gcaacttgcc ttcagtatgg   1140

tgaaacacat cagttaagac cggggttgtg catggcagga ctttctacaa ggacacccag   1200

tctccttaat aaacatgaga tgctctcttt ccagaatttc tcttgcctga cacagcatag   1260

gaagatgctg aacggccaca cagtgatcca ttgagataga atctcactat gttgaccagg   1320

ctggtcttga actcttggca cccaagcgat ccttttgcct ggaatcccaa agtgtcagat   1380

ttactgaaga atatttcatt gtaattactt tttatacttt ataggtcaag agctctgttt   1440

taaatacaaa atttattgaa tatacttttt caaacaaagt ttcatgttct aatcattgtc   1500

tgatttcagc attaaatgaa acacagtaaa gaaagttggg ctgatgttgt tgttggtggt   1560

tgtttttgta ttctgattac agaactgtat tttgagtggg ctgaacatag agtaaatgca   1620

tcctc                                                               1625


<210>  8020
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  8020

Met Tyr Arg Thr Ala Ser Asn Phe Cys Thr Leu Ile Leu Tyr Ala Lys 
1               5                   10                  15      


Thr Leu Leu Lys Phe Ile Ser Arg Arg Ser Phe Gly Ala Lys Thr Met 
            20                  25                  30          


Gly Leu Ser Arg Tyr Arg Asn Met Ser Ser Val Asn Arg Asp Ser Leu 
        35                  40                  45              


Thr Ser Cys Leu Phe Leu Ser Ser Leu Leu Cys Leu Asp Ala Leu Pro 
    50                  55                  60                  


Val Leu His Ile Gln Cys Asn Val Gly Cys Gly Phe Val Met Ala Ser 
65                  70                  75                  80  


Ser His His Phe Gly Thr Ser Asp 
                85              


<210>  8021
<211>  1543
<212>  DNA
<213>  Homosapiens

<400>  8021
ggattgtgtt cttcatttga ctctctgctt gacttgatgt ataggactgc tagtaatttt     60

tgcacattga ttttgtatgc taagactttg ctaaagttta tcagcagaag aagctttggg    120

gccaagacta tggggctttc tagatataga aacatgtcat ctgtaaacag agacagtttg    180

acttcctgtc tattcctctc ttccctcctc tgtttggatg cccttccagt tttgcacatt    240

cagtgtaatg ttggctgtgg gtttgtcatg gctagctctc atcattttgg cacttctgac    300

tagaagggca agaggggcca gtgttgttgt tacctgaaag gtaagtgcag cccacaaaaa    360

tgcagtgaag aagaagatgt attatgcata tgtttaagtt aatacaattg agatatattt    420

agcagacaga atcaatagag ttgatgagtg actgactgga tgtgtgggga gtttatatca    480

ctcccaggtt tttgacttgg gcaaccgggc actcatgaag gaaaaagagg atccagggag    540

aggaactttt ctgaggactg gggtagggct gaacagctgc attcgaggct ggtggagggt    600

gggctgggca tgggatgcac aaatggaaat tccactgggt ctgcagctca cacataggca    660

tgaccagcat agagatagag aggccccagt gctgctgagt aactgtgatt ccccaggtga    720

tggcatcagc tgagaaggga aggaagccca tgagaggaca ctgaagaagg agtgagcaga    780

caataagaag cccacagaag acagagaagg aacaactaga gggagaagcc aaggcaggcg    840

tgtgtgtttc tccacagaca ctacccaaag cagtgcttca ctacagtggc agacagacct    900

gaaaattttc atctgaagca gcagagtgaa ctgcagaggc aggtcaccaa ccagtgtgga    960

ggctaaaagc gggcctcttt ggggattcca ggtggaagtg ttggacatct gtagtattcc   1020

tggtctcgaa tcatcctgat attcttcatt ttgttattca cattggacta ggcaggaaca   1080

aagatcacca caactggctc gccttcaact atgttagatg gcaacttgcc ttcagtatgg   1140

tgaaacacat cagttaagac cggggttgtg catggcagga ctttctacaa ggacacccag   1200

tctccttaat aaacatgaga tgctctcttt ccagaatttc tcttgcctga cacagcatag   1260

gaagatgctg aacggccaca cagtgatcca ttgagataga atctcactat gttgaccagg   1320

ctggtcttga actcttggca cccaagcgat ccttttgcct ggaatcccaa agtgtcagat   1380

ttactgaaga atatttcatt gtaattactt tttatacttt ataggtcaag agctctgttt   1440

taaatacaaa atttattgaa tatacttttt caaacaaagt ttcatgttct aatcattgtc   1500

tgatttcagc attaaatgaa acacagtaaa gaaagttggg ctg                     1543


<210>  8022
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  8022

Met Tyr Arg Thr Ala Ser Asn Phe Cys Thr Leu Ile Leu Tyr Ala Lys 
1               5                   10                  15      


Thr Leu Leu Lys Phe Ile Ser Arg Arg Ser Phe Gly Ala Lys Thr Met 
            20                  25                  30          


Gly Leu Ser Arg Tyr Arg Asn Met Ser Ser Val Asn Arg Asp Ser Leu 
        35                  40                  45              


Thr Ser Cys Leu Phe Leu Ser Ser Leu Leu Cys Leu Asp Ala Leu Pro 
    50                  55                  60                  


Val Leu His Ile Gln Cys Asn Val Gly Cys Gly Phe Val Met Ala Ser 
65                  70                  75                  80  


Ser His His Phe Gly Thr Ser Asp 
                85              


<210>  8023
<211>  1322
<212>  DNA
<213>  Homosapiens

<400>  8023
ggattgtgtt cttcatttga ctctctgctt gacttgatgt ataggactgc tagtaatttt     60

tgcacattga ttttgtatgc taagactttg ctaaagttta tcagcagaag aagctttggg    120

gccaagacta tggggctttc tagatataga aacatgtcat ctgtaaacag agacagtttg    180

acttcctgtc tattcctctc ttccctcctc tgtttggatg cccttccagt tttgcacatt    240

cagtgtaatg ttggctgtgg gtttgtcatg gctagctctc atcattttgg cacttctgac    300

tagaagggca agaggggcca gtgttgttgt tacctgaaag gtaagtgcag cccacaaaaa    360

tgcagtgaag aagaagatgt attatgcata tgtttaagtt aatacaattg agatatattt    420

agcagacaga atcaatagag ttgatgagtg actgactgga tgtgtgggga gtttatatca    480

ctcccaggtt tttgacttgg gcaaccgggc actcatgaag gaaaaagagg atccagggag    540

aggaactttt ctgaggactg gggtagggct gaacagctgc attcgaggct ggtggagggt    600

gggctgggca tgggatgcac aaatggaaat tccactgggt ctgcagctca cacataggca    660

tgaccagcat agagatagag aggccccagt gctgctgagt aactgtgatt ccccaggtga    720

tggcatcagc tgagaaggga aggaagccca tgagaggaca ctgaagaagg agtgagcaga    780

caataagaag cccacagaag acagagaagg aacaactaga gggagaagcc aaggcaggcg    840

tgtgtgtttc tccacagaca ctacccaaag cagtgcttca ctacagtggc agacagacct    900

gaaaattttc atctgaagca gcagagtgaa ctgcagaggc aggtcaccaa ccagtgtgga    960

ggctaaaagc gggcctcttt ggggattcca ggtggaagtg ttggacatct gtagtattcc   1020

tggtctcgaa tcatcctgat attcttcatt ttgttattca cattggacta ggagatagaa   1080

tctcactatg ttgaccaggc tggtcttgaa ctcttggcac ccaagcgatc cttttgcctg   1140

gaatcccaaa gtgtcagatt tactgaagaa tatttcattg taattacttt ttatacttta   1200

taggtcaaga gctctgtttt aaatacaaaa tttattgaat atactttttc aaacaaagtt   1260

tcatgttcta atcattgtct gatttcagca ttaaatgaaa cacagtaaag aaagttgggc   1320

tg                                                                  1322


<210>  8024
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  8024

Met Tyr Arg Thr Ala Ser Asn Phe Cys Thr Leu Ile Leu Tyr Ala Lys 
1               5                   10                  15      


Thr Leu Leu Lys Phe Ile Ser Arg Arg Ser Phe Gly Ala Lys Thr Met 
            20                  25                  30          


Gly Leu Ser Arg Tyr Arg Asn Met Ser Ser Val Asn Arg Asp Ser Leu 
        35                  40                  45              


Thr Ser Cys Leu Phe Leu Ser Ser Leu Leu Cys Leu Asp Ala Leu Pro 
    50                  55                  60                  


Val Leu His Ile Gln Cys Asn Val Gly Cys Gly Phe Val Met Ala Ser 
65                  70                  75                  80  


Ser His His Phe Gly Thr Ser Asp 
                85              


<210>  8025
<211>  1838
<212>  DNA
<213>  Homosapiens

<400>  8025
ggattgtgtt cttcatttga ctctctgctt gacttgatgt ataggactgc tagtaatttt     60

tgcacattga ttttgtatgc taagactttg ctaaagttta tcagcagaag aagctttggg    120

gccaagacta tggggctttc tagatataga aacatgtcat ctgtaaacag agacagtttg    180

acttcctgtc tattcctctc ttccctcctc tgtttggatg cccttccagt tttgcacatt    240

cagtgtaatg ttggctgtgg gtttgtcatg gctagctctc atcattttgg cacttctgac    300

tagaagggca agaggggcca gtgttgttgt tacctgaaag gtaagtgcag cccacaaaaa    360

tgcagtgaag aagaagatgt attatgcata tgtttaagtt aatacaattg agatatattt    420

agcagacaga atcaatagag ttgatgagtg actgactgga tgtgtgggga gtttatatca    480

ctcccaggtt tttgacttgg gcaaccgggc actcatgaag gaaaaagagg atccagggag    540

aggaactttt ctgaggactg gggtagggct gaacagctgc attcgaggct ggtggagggt    600

gggctgggca tgggatgcac aaatggaaat tccactgggt ctgcagctca cacataggca    660

tgaccagcat agagatagag aggccccagt gctgctgagt aactgtgatt ccccaggtga    720

tggcatcagc tgagaaggga aggaagccca tgagaggaca ctgaagaagg agtgagcaga    780

caataagaag cccacagaag acagagaagg aacaactaga gggagaagcc aaggcaggcg    840

tgtgtggtaa cacataggaa ctgagggaga ggacatttca agatggtggg gatgccatac    900

aacaggacta tgtgatgatt tttggctgtg tccataggaa gtcacaacag gcaagggaaa    960

gaaaccagaa cccagtcatg gagctaagaa gtgagtcaga gagtagaggg gtagggacag   1020

tgaggtaagt cctctttcta aggaagtttg gctgaaggat agactagctg gacacatgct   1080

ggctgtgtgg ggtagaggga ggaatgatgg agggtaggag agccttgagc ctgcgagaag   1140

agtctcttag aatagagaag ctgaagttaa agttgtggaa gagagtgggg ataactgagt   1200

gacagataat caggagaaga aaaggagatc cagactcatg acagagagat gacctttgcc   1260

aagagtacag ccgtctttca cggtcacaga gaggtaggac aaaatgagtg gtgttcaaga   1320

attggtttgt agcacaatat ttcaactatg tcctttaaaa agtttctcca cagacactac   1380

ccaaagcagt gcttcactac agtggcagac agacctgaaa attttcatct gaagcagcag   1440

agtgaactgc agaggcaggt caccaaccag tgtggaggct aaaagcgggc ctctttgggg   1500

attccaggtg gaagtgttgg acatctgtag tattcctggt ctcgaatcat cctgatattc   1560

ttcattttgt tattcacatt ggactaggag atagaatctc actatgttga ccaggctggt   1620

cttgaactct tggcacccaa gcgatccttt tgcctggaat cccaaagtgt cagatttact   1680

gaagaatatt tcattgtaat tactttttat actttatagg tcaagagctc tgttttaaat   1740

acaaaattta ttgaatatac tttttcaaac aaagtttcat gttctaatca ttgtctgatt   1800

tcagcattaa atgaaacaca gtaaagaaag ttgggctg                           1838


<210>  8026
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  8026

Met Ser Phe Lys Lys Phe Leu His Arg His Tyr Pro Lys Gln Cys Phe 
1               5                   10                  15      


Thr Thr Val Ala Asp Arg Pro Glu Asn Phe His Leu Lys Gln Gln Ser 
            20                  25                  30          


Glu Leu Gln Arg Gln Val Thr Asn Gln Cys Gly Gly 
        35                  40                  


<210>  8027
<211>  787
<212>  DNA
<213>  Homosapiens

<400>  8027
atcccacatc aaaaagttag gaagaactca aattaataac ctaacatcac aactgaaaga     60

actagagaag caagacaaaa ccccaaagct agaggaagac aagaaataac tgaaaatctg    120

agctgaactg aaagaaaccg agacatgaaa aaaagaaatt caaaagatct atgaattccg    180

ggtgatggca tcagctgaga agggaaggaa gcccatgaga ggacactgaa gaaggagtga    240

gcagacaata agaagcccac agaagacaga gaaggaacaa ctagagggag aagccaaggc    300

aggcgtgtgt gtttctccac agacactacc caaagcagtg cttcactaca gtggcagaca    360

gacctgaaaa ttttcatctg aagcagcaga gtgaactgca gaggcaggtc accaaccagt    420

gtggaggcta aaagcgggcc tctttgggga ttccaggtgg aagtgttgga catctgtagt    480

attcctggtc tcgaatcatc ctgatattct tcattttgtt attcacattg gactaggaga    540

tagaatctca ctatgttgac caggctggtc ttgaactctt ggcacccaag cgatcctttt    600

gcctggaatc ccaaagtgtc agatttactg aagaatattt cattgtaatt actttttata    660

ctttataggt caagagctct gttttaaata caaaatttat tgaatatact ttttcaaaca    720

aagtttcatg ttctaatcat tgtctgattt cagcattaaa tgaaacacag taaagaaagt    780

tgggctg                                                              787


<210>  8028
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  8028

Met Leu Thr Arg Leu Val Leu Asn Ser Trp His Pro Ser Asp Pro Phe 
1               5                   10                  15      


Ala Trp Asn Pro Lys Val Ser Asp Leu Leu Lys Asn Ile Ser Leu 
            20                  25                  30      


<210>  8029
<211>  1770
<212>  DNA
<213>  Homosapiens

<400>  8029
ggattgtgtt cttcatttga ctctctgctt gacttgatgt ataggactgc tagtaatttt     60

tgcacattga ttttgtatgc taagactttg ctaaagttta tcagcagaag aagctttggg    120

gccaagacta tggggctttc tagatataga aacatgtcat ctgtaaacag agacagtttg    180

acttcctgtc tattcctctc ttccctcctc tgtttggatg cccttccagt tttgcacatt    240

cagtgtaatg ttggctgtgg gtttgtcatg gctagctctc atcattttgg cacttctgac    300

tagaagggca agaggggcca gtgttgttgt tacctgaaag gtaagtgcag cccacaaaaa    360

tgcagtgaag aagaagatgt attatgcata tgtttaagtt aatacaattg agatatattt    420

agcagacaga atcaatagag ttgatgagtg actgactgga tgtgtgggga gtttatatca    480

ctcccaggtt tttgacttgg gcaaccgggc actcatgaag gaaaaagagg atccagggag    540

aggaactttt ctgaggactg gggtagggct gaacagctgc attcgaggct ggtggagggt    600

gggctgggca tgggatgcac aaatggaaat tccactgggt ctgcagctca cacataggca    660

tgaccagcat agagatagag aggccccagt gctgctgagt aactgtgatt ccccaggtga    720

tggcatcagc tgagaaggga aggaagccca tgagaggaca ctgaagaagg agtgagcaga    780

caataagaag cccacagaag acagagaagg aacaactaga gggagaagcc aaggcaggcg    840

tgtgtggtaa cacataggaa ctgagggaga ggacatttca agatggtggg gatgccatac    900

aacaggacta tgtgatgatt tttggctgtg tccataggaa gtcacaacag gcaagggaaa    960

gaaaccagaa cccagtcatg gagctaagaa gtgagtcaga gagtagaggg gtagggacag   1020

tgaggtaagt cctctttcta aggaagtttg gctgaaggat agactagctg gacacatgct   1080

ggctgtgtgg ggtagaggga ggaatgatgg agggtaggag agccttgagc ctgcgagaag   1140

agtctcttag aatagagaag ctgaagttaa agttgtggaa gagagtgggg ataactgagt   1200

gacagataat caggagaaga aaaggagatc cagactcatg acagagagat gacctttgcc   1260

aagagtacag ccgtctttca cggtcacaga gaggtaggac aaaatgagtg gtgttcaaga   1320

attggtttgt agcacaatat ttcaactatg tcctttaaaa agtttctcca cagacactac   1380

ccaaagcagt gcttcactac agtggcagac agacctgaaa attttcatct gaagcagcag   1440

agtgaactgc agaggcaggt caccaaccag tgtggaggct aaaagcgggc ctctttgggg   1500

attccaggtg gaagtgttgg acatctgtag tattcctggt ctcgaatcat cctgatattc   1560

ttcattttgt tattcacatt ggactaggag atagaatctc actatgttga ccaggctggt   1620

cttgaactct tggcacccaa gcgatccttt tgcctggaat cccaaagtgt cagatttact   1680

gaagaatatt tcattgtaat tactttttat actttatagg tcaagagctc tgttttaaat   1740

acaaaattta ttgaatatac tttttcaaac                                    1770


<210>  8030
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  8030

Met Ser Phe Lys Lys Phe Leu His Arg His Tyr Pro Lys Gln Cys Phe 
1               5                   10                  15      


Thr Thr Val Ala Asp Arg Pro Glu Asn Phe His Leu Lys Gln Gln Ser 
            20                  25                  30          


Glu Leu Gln Arg Gln Val Thr Asn Gln Cys Gly Gly 
        35                  40                  


<210>  8031
<211>  2813
<212>  DNA
<213>  Homosapiens

<400>  8031
ctcctcccca actcattcta tgaggccaac atcatcttga taccaaaatc tggcagatac     60

acacacacac acacacacac acacacacac acaatcttca ggccaatacc ctcgatgaac    120

atcaatgcaa aaatcctcaa caaaatactg gcaaaccaaa tccagcagca catcaaaaag    180

ttaatccatc atgatcaagt atgcttcatc cccaggatgc aaggttgcct caacatacac    240

atatcaatta atctgattca tcacatgaac aaaactaaag ataaaaacca tgtggttatc    300

tcaatataag cagaaaaggc tttcaataaa attcaatgcc tctccatatt aaaaactcta    360

aaaaatctgg gtattgaaga aacatagctc aaaatgatga gctgtttttg tatcagtatc    420

atgctgtttt ggttactgta gccctgtagt atggtttgaa gttgggtaac atgatgcctc    480

cagcttcgtt ctttttgctg aggattgctt ggctattagg gctctttttt ttggttccat    540

atgaattttg aaatagtttg ctctagttct gtgaggaatg ccgttggtaa tttaataggg    600

ataacttgca tctgtaaatt actttgggca gtatagccat tttaatgaca ttaattcttc    660

ctatccatga gcatgacatg tttttccatt tgtttctgtc ttctctgatt tctttgagca    720

gtgttttgta attcttctag agatctccta gagatctttc acctccctgg ttagctgtat    780

tcctaggtat cttatttttt ctgtgtgtag caattatgaa tgggattgtg ttcttcattt    840

gactctctgc ttgacttgat gtataggact gctagtaatt tttgcacatt gattttgtat    900

gctaagactt tgctaaagtt tatcagcaga agaagctttg gggccaagac tatggggctt    960

tctagatata gaaacatgtc atctgtaaac agagacagtt tgacttcctg tctattcctc   1020

tcttccctcc tctgtttgga tgcccttcca gttttgcaca ttcagtgtaa tgttggctgt   1080

gggtttgtca tggctagctc tcatcatttt ggcacttctg actagaaggg caagaggggc   1140

cagtgttgtt gttacctgaa aggtaagtgc agcccacaaa aatgcagtga agaagaagat   1200

gtattatgca tatgtttaag ttaatacaat tgagatatat ttagcagaca gaatcaatag   1260

agttgatgag tgactgactg gatgtgtggg gagtttatat cactcccagg tttttgactt   1320

gggcaaccgg gcactcatga aggaaaaaga ggatccaggg agaggaactt ttctgaggac   1380

tggggtaggg ctgaacagct gcattcgagg ctggtggagg gtgggctggg catgggatgc   1440

acaaatggaa attccactgg gtctgcagct cacacatagg catgaccagc atagagatag   1500

agaggcccca gtgctgctga gtaactgtga ttccccaggt gatggcatca gctgagaagg   1560

gaaggaagcc catgagagga cactgaagaa ggagtgagca gacaataaga agcccacaga   1620

agacagagaa ggaacaacta gagggagaag ccaaggcagg cgtgtgtggt aacacatagg   1680

aactgaggga gaggacattt caagatggtg gggatgccat acaacaggac tatgtgatga   1740

tttttggctg tgtccatagg aagtcacaac aggcaaggga aagaaaccag aacccagtca   1800

tggagctaag aagtgagtca gagagtagag gggtagggac agtgaggtaa gtcctctttc   1860

taaggaagtt tggctgaagg atagactagc tggacacatg ctggctgtgt ggggtagagg   1920

gaggaatgat ggagggtagg agagccttga gcctgcgaga agagtctctt agaatagaga   1980

agctgaagtt aaagttgtgg aagagagtgg ggataactga gtgacagata atcaggagaa   2040

gaaaaggaga tccagactca tgacagagag atgacctttg ccaagagtac agccgtcttt   2100

cacggtcaca gagaggtagg acaaaatgag tggtgttcaa gaattggttt gtagcacaat   2160

atttcaacta tgtcctttaa aaagtttctc cacagacact acccaaagca gtgcttcact   2220

acagtggcag acagacctga aaattttcat ctgaagcagc agagtgaact gcagaggcag   2280

gtcaccaacc agtgtggagg ctaaaagcgg gcctctttgg ggattccagg tggaagtgtt   2340

ggacatctgt agtattcctg gtctcgaatc atcctgatat tcttcatttt gttattcaca   2400

ttggactagg caggaacaaa gatcaccaca actggctcgc cttcaactat gttagatggc   2460

aacttgcctt cagtatggtg aaacacatca gttaagaccg gggttgtgca tggcaggact   2520

ttctacaagg acacccagtc tccttaataa acatgagatg ctctctttcc agaatttctc   2580

ttgcctgaca cagcatagga agatgctgaa cggccacaca gtgatccatt gagatagaat   2640

ctcactatgt tgaccaggct ggtcttgaac tcttggcacc caagcgatcc ttttgcctgg   2700

aatcccaaag tgtcagattt actgaagaat atttcattgt aattactttt tatactttat   2760

aggtcaagag ctctgtttta aatacaaaat ttattgaata tactttttca aac          2813


<210>  8032
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  8032

Met Ser Phe Lys Lys Phe Leu His Arg His Tyr Pro Lys Gln Cys Phe 
1               5                   10                  15      


Thr Thr Val Ala Asp Arg Pro Glu Asn Phe His Leu Lys Gln Gln Ser 
            20                  25                  30          


Glu Leu Gln Arg Gln Val Thr Asn Gln Cys Gly Gly 
        35                  40                  


<210>  8033
<211>  576
<212>  DNA
<213>  Homosapiens

<400>  8033
aagttaggaa gaactcaaat taataaccta acatcacaac tgaaagaact agagaagcaa     60

gacaaaaccc caaagctaga ggaagacaag aaataactga aaatctgagc tgaactgaaa    120

gaaaccgaga catgaaaaaa agaaattcaa aagatctatg aattccggtt tctccacaga    180

cactacccaa agcagtgctt cactacagtg gcagacagac ctgaaaattt tcatctgaag    240

cagcagagtg aactgcagag gcaggtcacc aaccagtgtg gaggctaaaa gcgggcctct    300

ttggggattc caggtggaag tgttggacat ctgtagtatt cctggtctcg aatcatcctg    360

atattcttca ttttgttatt cacattggac taggagatag aatctcacta tgttgaccag    420

gctggtcttg aactcttggc acccaagcga tccttttgcc tggaatccca aagtgtcaga    480

tttactgaag aatatttcat tgtaattact ttttatactt tataggtcaa gagctctgtt    540

ttaaatacaa aatttattga atatactttt tcaaac                              576


<210>  8034
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  8034

Met Leu Thr Arg Leu Val Leu Asn Ser Trp His Pro Ser Asp Pro Phe 
1               5                   10                  15      


Ala Trp Asn Pro Lys Val Ser Asp Leu Leu Lys Asn Ile Ser Leu 
            20                  25                  30      


<210>  8035
<211>  576
<212>  DNA
<213>  Homosapiens

<400>  8035
tttgagcaag atcttaaaga aaatcagatg ccttcacctg accactgctt ggtgatccca     60

tggcactttg tacatctctc cattagctct catctcacca gcccatcatt attgtatgtg    120

ctgccttctg aagcttgcag ctggctacat cagtccaatg tgaataacaa aatgaagaat    180

atcaggatga ttcgagacca ggaatactac agatgtccaa cacttccacc tggaatcccc    240

aaagaggccc gcttttagcc tccacactgg ttggtgacct gacatgagag aaatgacaga    300

aatctcagaa gactggcctc atgaataatc ttcagtttca atgtaacaaa gcaagccttc    360

tagaaattac ctgcctctgc agttcactct gctgcttcag atgaaaattt tcagagttcc    420

accacccctg gagaatacag caactgttta ctgcaatcag caatcaggat ggagaattcg    480

tgctgtgggg gccaatccag gggttccctg tcatgagcag tggggagtgt gtagaaccca    540

tgagagatgg gctttggtca attaaagctt gttgaa                              576


<210>  8036
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  8036

Met Pro Ser Pro Asp His Cys Leu Val Ile Pro Trp His Phe Val His 
1               5                   10                  15      


Leu Ser Ile Ser Ser His Leu Thr Ser Pro Ser Leu Leu Tyr Val Leu 
            20                  25                  30          


Pro Ser Glu Ala Cys Ser Trp Leu His Gln Ser Asn Val Asn Asn Lys 
        35                  40                  45              


Met Lys Asn Ile Arg Met Ile Arg Asp Gln Glu Tyr Tyr Arg Cys Pro 
    50                  55                  60                  


Thr Leu Pro Pro Gly Ile Pro Lys Glu Ala Arg Phe 
65                  70                  75      


<210>  8037
<211>  388
<212>  DNA
<213>  Homosapiens

<400>  8037
tttctccaca gacactaccc aaagcagtgc ttcactacag tggcagacag acctgaaaat     60

tttcatctga agcagcagag tgaactgcag aggcaggtca ccaaccagtg tggaggctaa    120

aagcgggcct ctttggggat tccaggtgga agtgttggac atctgtagta ttcctggtct    180

cgaatcatcc tgatattctt cattttgtta ttcacattgg actaggcagg aacaaagatc    240

accacaactg gctcgccttc aactatgtta gatggcaact tgccttcagt atggtgaaac    300

acatcagtta agaccggggt tgtgcatggc aggactttct acaaggacac ccagtctcct    360

taataaacat gagatgctct ctttccag                                       388


<210>  8038
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  8038

Met Ala Thr Cys Leu Gln Tyr Gly Glu Thr His Gln Leu Arg Pro Gly 
1               5                   10                  15      


Leu Cys Met Ala Gly Leu Ser Thr Arg Thr Pro Ser Leu Leu Asn Lys 
            20                  25                  30          


His Glu Met Leu Ser Phe 
        35              


<210>  8039
<211>  1944
<212>  DNA
<213>  Homosapiens

<400>  8039
cagtatagcc attttaatga cattaattct tcctatccat gagcatgaca tgtttttcca     60

tttgtttctg tcttctctga tttctttgag cagtgttttg taattcttct agagatctcc    120

tagagatctt tcacctccct ggttagctgt attcctaggt atcttatttt ttctgtgtgt    180

agcaattatg aatgggattg tgttcttcat ttgactctct gcttgacttg atgtatagga    240

ctgctagtaa tttttgcaca ttgattttgt atgctaagac tttgctaaag tttatcagca    300

gaagaagctt tggggccaag actatggggc tttctagata tagaaacatg tcatctgtaa    360

acagagacag tttgacttcc tgtctattcc tctcttccct cctctgtttg gatgcccttc    420

cagttttgca cattcagtgt aatgttggct gtgggtttgt catggctagc tctcatcatt    480

ttggcacttc tgactagaag ggcaagaggg gccagtgttg ttgttacctg aaaggtaagt    540

gcagcccaca aaaatgcagt gaagaagaag atgtattatg catatgttta agttaataca    600

attgagatat atttagcaga cagaatcaat agagttgatg agtgactgac tggatgtgtg    660

gggagtttat atcactccca ggtttttgac ttgggcaacc gggcactcat gaaggaaaaa    720

gaggatccag ggagaggaac ttttctgagg actggggtag ggctgaacag ctgcattcga    780

ggctggtgga gggtgggctg ggcatgggat gcacaaatgg aaattccact gggtctgcag    840

ctcacacata ggcatgacca gcatagagat agagaggccc cagtgctgct gagtaactgt    900

gattccccag gtgatggcat cagctgagaa gggaaggaag cccatgagag gacactgaag    960

aaggagtgag cagacaataa gaagcccaca gaagacagag aaggaacaac tagagggaga   1020

agccaaggca ggcgtgtgtg gtaacacata ggaactgagg gagaggacat ttcaagatgg   1080

tggggatgcc atacaacagg actatgtgat gatttttggc tgtgtccata ggaagtcaca   1140

acaggcaagg gaaagaaacc agaacccagt catggagcta agaagtgagt cagagagtag   1200

aggggtaggg acagtgaggt aagtcctctt tctaaggaag tttggctgaa ggatagacta   1260

gctggacaca tgctggctgt gtggggtaga gggaggaatg atggagggta ggagagcctt   1320

gagcctgcga gaagagtctc ttagaataga gaagctgaag ttaaagttgt ggaagagagt   1380

ggggataact gagtgacaga taatcaggag aagaaaagga gatccagact catgacagag   1440

agatgacctt tgccaagagt acagccgtct ttcacggtca cagagaggta ggacaaaatg   1500

agtggtgttc aagaattggt ttgtagcaca atatttcaac tatgtccttt aaaaagtttc   1560

tccacagaca ctacccaaag cagtgcttca ctacagtggc agacagacct gaaaattttc   1620

atctgaagca gcagagtgaa ctgcagaggc aggtcaccaa ccagtgtgga ggctaaaagc   1680

gggcctcttt ggggattcca ggtggaagtg ttggacatct gtagtattcc tggtctcgaa   1740

tcatcctgat attcttcatt ttgttattca cattggacta ggcaggaaca aagatcacca   1800

caactggctc gccttcaact atgttagatg gcaacttgcc ttcagtatgg tgaaacacat   1860

cagttaagac cggggttgtg catggcagga ctttctacaa ggacacccag tctccttaat   1920

aaacatgaga tgctctcttt ccag                                          1944


<210>  8040
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  8040

Met Ser Phe Lys Lys Phe Leu His Arg His Tyr Pro Lys Gln Cys Phe 
1               5                   10                  15      


Thr Thr Val Ala Asp Arg Pro Glu Asn Phe His Leu Lys Gln Gln Ser 
            20                  25                  30          


Glu Leu Gln Arg Gln Val Thr Asn Gln Cys Gly Gly 
        35                  40                  


<210>  8041
<211>  2869
<212>  DNA
<213>  Homosapiens

<400>  8041
atgctgctcg atgtgatcat gatcaaagtc actcatcaaa aagagaccaa gagcttgctt     60

tccagggcac agtagataaa tgtcgtcact tacaggaaaa tttgaattct catgttctga    120

ttctttctct gcaactttct aaagctgaga gtaagtccag agtcctcaaa actgagctcc    180

attacacagg agaggctctg aaagaaaagg ctttggtttt tgaacacgtg caaagtgagc    240

taaagcaaaa acagagtcaa atgaaggaca ttgaaaaaat gtacaaaagt ggatacaata    300

caatggaaaa atgcatagaa aaacaggaaa gattttgtca actaaaaaaa caaaatatgt    360

tgcttcaaca gcaactggat gatgctcgca acaaagctga caatcaagaa aaagcaatac    420

ttaatattca agccagatgt gatgctagag tacaaaacct tcaagctgag tgcagaaagc    480

accgtctttt actagaagaa gacaataaaa tgttggtcaa tgaactgaat cattcgaaag    540

aaaaagaatg ccaatatgaa aaagagaaag cagaaagaga agtagctgtg agacagcttc    600

aacaaaaacg agatgatgtc ttaaacaaag gatcagcaac aaaagctctg ctggatgctt    660

catcgcgtca ctgcacctat ttagaaaatg ggatgcagga ttcaaggaag aaattagacc    720

agatgagaag tcaatttcaa gaaatacagg atcaacttac agctactata agatgtacta    780

aggagatgga aggcgacaca caaaagcttg aagtagaaca tgtgatgatg agaaaaatta    840

ttaaaaaaca ggatgaccaa attgagcggc ttgagaaaat cctgcagcat tcaagtttga    900

tgctgcaggt gtttgagagc tagatgaaga tatggacatt tctggaatta agagccccct    960

ctacattgag cacaagacag tgacgaatcc acattcttca gccagaaagt cacctctgag   1020

agccaaatgt ctgactatag aaaggagagt caaagaatga taacgacatc tcaggaaaat   1080

tgtgaaaata atcagcagcc ggatgtggat aaccctttca aatttctcca ggggcctcca   1140

accaccccca ctggtgttct cctgctgaca gtgatttcaa ttttttctgg gctggagctc   1200

cctgatggag gggcaggcca ccatctttgc tgtttttgca acttagccac ttcaaccttc   1260

agtctttgga gtgtccaagg agaccagggg gtgatgtgga ccctcagcat agcacagctg   1320

ctctataaaa atgaggccag actgcttttt taagcacttt cccaatgcca ttcctcctca   1380

ctgggcaaaa cctccaaact ggggtctcca gccacctcct acaggtgtgt ttgggccagc   1440

aacaagttca ttcatacctc cctagggcaa agcttccaaa gggagcggta ggctgccatc   1500

tttgctgttt cacaggcttc actgatgata actccaggta ctggaaaatc tgaggctact   1560

agagactgga gcgggccctg ggcatactgc agcagcccta tggaaaagtg gccagactgt   1620

tacctgggtt cccattccta tatcttctca ctaggcaagt cttgcaggcc tggacctcta   1680

cctaaccccc cctaccagaa ctgttgagcc agtagcaact cagccactcc ctggagagag   1740

cctccagggg caactgaaag cctctctgcc actgcttctg cagtggaact gtccttgcta   1800

ccctcagact gatgaaggag ctaacaccct tatctacacc ttcaacaagc tttaattgac   1860

caaagcccat ctctcatggg ttctacacac tccccactgc tcatgacagg gaacccctgg   1920

attggccccc acagcacgaa ttctccatcc tgattgctga ttgcagtaaa cagttgctgt   1980

attctccagg ggtggtggaa ctctgaggag acaaacaaaa gacccttggc tacaaccact   2040

actaatgtcc cttcctcttc tgcctcaaag ttaggaaaga aatataaaca ctgagattgc   2100

cccagagctg cagtgggcag cctaggagtg ccaagccatg acctacagcc agcactcaag   2160

ggggagagaa gcacattttc agatcattga gagggaacat ggctgcaact gtaaggaaac   2220

ataggggagc cacatgacca agcaagagtc taccaactga ccagtaagcc caagtgccac   2280

ctactggatc acatcccaaa gcttcagcat caaaaatacc ttactaatat actcccctct   2340

gaaaccagaa atgagaagtc agcttcaaat aaagaccctg cacaaagcct cagcctggtg   2400

aaaacatccg aaaataagtc tacggactgt actcaatcta cactgcaatt aaaggaaaac   2460

ccataggtgg aaatgagaag aaaccaatgc aagaactcca gtaactcaaa tggcctctgt   2520

gtcatatgtc cttctaacaa ccacaccagt tctccaacaa gagttcttaa cctggatgaa   2580

ctgtctggaa ttacataaat ataattcaga atatggatag gaaaaaaaat catcaagact   2640

caggagaatg gcaaaaccca atccaaggaa aataagaata acagtaaagt gttacaggag   2700

ctgaaggata aagtagctgg tataataaaa aagaacctaa ccgatctgaa agcgccgaag   2760

aacacaatac aagaattcca caatgcaatc acaagtatta acagcagaaa aaaaaacctg   2820

aggaacgaat ctcagaactt gaagattggt tctctaaaat aagatggac               2869


<210>  8042
<211>  220
<212>  PRT
<213>  Homosapiens

<400>  8042

Met Lys Asp Ile Glu Lys Met Tyr Lys Ser Gly Tyr Asn Thr Met Glu 
1               5                   10                  15      


Lys Cys Ile Glu Lys Gln Glu Arg Phe Cys Gln Leu Lys Lys Gln Asn 
            20                  25                  30          


Met Leu Leu Gln Gln Gln Leu Asp Asp Ala Arg Asn Lys Ala Asp Asn 
        35                  40                  45              


Gln Glu Lys Ala Ile Leu Asn Ile Gln Ala Arg Cys Asp Ala Arg Val 
    50                  55                  60                  


Gln Asn Leu Gln Ala Glu Cys Arg Lys His Arg Leu Leu Leu Glu Glu 
65                  70                  75                  80  


Asp Asn Lys Met Leu Val Asn Glu Leu Asn His Ser Lys Glu Lys Glu 
                85                  90                  95      


Cys Gln Tyr Glu Lys Glu Lys Ala Glu Arg Glu Val Ala Val Arg Gln 
            100                 105                 110         


Leu Gln Gln Lys Arg Asp Asp Val Leu Asn Lys Gly Ser Ala Thr Lys 
        115                 120                 125             


Ala Leu Leu Asp Ala Ser Ser Arg His Cys Thr Tyr Leu Glu Asn Gly 
    130                 135                 140                 


Met Gln Asp Ser Arg Lys Lys Leu Asp Gln Met Arg Ser Gln Phe Gln 
145                 150                 155                 160 


Glu Ile Gln Asp Gln Leu Thr Ala Thr Ile Arg Cys Thr Lys Glu Met 
                165                 170                 175     


Glu Gly Asp Thr Gln Lys Leu Glu Val Glu His Val Met Met Arg Lys 
            180                 185                 190         


Ile Ile Lys Lys Gln Asp Asp Gln Ile Glu Arg Leu Glu Lys Ile Leu 
        195                 200                 205             


Gln His Ser Ser Leu Met Leu Gln Val Phe Glu Ser 
    210                 215                 220 


<210>  8043
<211>  1456
<212>  DNA
<213>  Homosapiens

<400>  8043
atgctgctcg atgtgatcat gatcaaagtc actcatcaaa aagagaccaa gagcttgctt     60

tccagggcac agtagataaa tgtcgtcact tacaggaaaa tttgaattct catgttctga    120

ttctttctct gcaactttct aaagctgaga gtaagtccag agtcctcaaa actgagctcc    180

attacacagg agaggctctg aaagaaaagg ctttggtttt tgaacacgtg caaagtgagc    240

taaagcaaaa acagagtcaa atgaaggaca ttgaaaaaat gtacaaaagt ggatacaata    300

caatggaaaa atgcatagaa aaacaggaaa gattttgtca actaaaaaaa caaaatatgt    360

tgcttcaaca gcaactggat gatgctcgca acaaagctga caatcaagaa aaagcaatac    420

ttaatattca agccagatgt gatgctagag tacaaaacct tcaagctgag tgcagaaagc    480

accgtctttt actagaagaa gacaataaaa tgttggtcaa tgaactgaat cattcgaaag    540

aaaaagaatg ccaatatgaa aaagagaaag cagaaagaga agtagctgtg agacagcttc    600

aacaaaaacg agatgatgtc ttaaacaaag gatcagcaac aaaagctctg ctggatgctt    660

catcgcgtca ctgcacctat ttagaaaatg ggatgcagga ttcaaggaag aaattagacc    720

agatgagaag tcaatttcaa gaaatacagg atcaacttac agctactata agatgtacta    780

aggagatgga aggcgacaca caaaagtaaa atttgaagca gcacacaaaa taacttgagt    840

atttataaag caaaagagca ctgtagtatg aaaattgtat cagttatgat aattagtatg    900

tctttgtgaa gccaaaaaag tttcatttgt aagctatatc gaaatacatc atttttctac    960

attattccta aattttgcat attatcacca aaacacaggt agaaaatgac acagtagccc   1020

aatcgtctac ttttgtgatt gctaagaatt tgtgtaatta taccttcaga agtttgttta   1080

gaatttacat gatttaaaaa aaattacgtg tgagagtaat tattttaaaa tgcacatttt   1140

aggcttgaag tagaacatgt gatgatgaga aaaattatta aaaaacagga tgaccaaatt   1200

gagcggcttg agaaaatcct gcagcattca agtttgatgc tgcaggtgtt tgagagctag   1260

atgaagatat ggacatttct ggaattaaga gccccctcta cattgagcac aagacagtga   1320

cgaatccaca ttcttcagcc agaaagtcac ctctgagagc caaatgtctg actatagaaa   1380

ggagagtcaa agaatgataa cgacatctca ggaaaattgt gaaaataatc agcagccgga   1440

tgtggataac cctttc                                                   1456


<210>  8044
<211>  182
<212>  PRT
<213>  Homosapiens

<400>  8044

Met Lys Asp Ile Glu Lys Met Tyr Lys Ser Gly Tyr Asn Thr Met Glu 
1               5                   10                  15      


Lys Cys Ile Glu Lys Gln Glu Arg Phe Cys Gln Leu Lys Lys Gln Asn 
            20                  25                  30          


Met Leu Leu Gln Gln Gln Leu Asp Asp Ala Arg Asn Lys Ala Asp Asn 
        35                  40                  45              


Gln Glu Lys Ala Ile Leu Asn Ile Gln Ala Arg Cys Asp Ala Arg Val 
    50                  55                  60                  


Gln Asn Leu Gln Ala Glu Cys Arg Lys His Arg Leu Leu Leu Glu Glu 
65                  70                  75                  80  


Asp Asn Lys Met Leu Val Asn Glu Leu Asn His Ser Lys Glu Lys Glu 
                85                  90                  95      


Cys Gln Tyr Glu Lys Glu Lys Ala Glu Arg Glu Val Ala Val Arg Gln 
            100                 105                 110         


Leu Gln Gln Lys Arg Asp Asp Val Leu Asn Lys Gly Ser Ala Thr Lys 
        115                 120                 125             


Ala Leu Leu Asp Ala Ser Ser Arg His Cys Thr Tyr Leu Glu Asn Gly 
    130                 135                 140                 


Met Gln Asp Ser Arg Lys Lys Leu Asp Gln Met Arg Ser Gln Phe Gln 
145                 150                 155                 160 


Glu Ile Gln Asp Gln Leu Thr Ala Thr Ile Arg Cys Thr Lys Glu Met 
                165                 170                 175     


Glu Gly Asp Thr Gln Lys 
            180         


<210>  8045
<211>  2493
<212>  DNA
<213>  Homosapiens

<400>  8045
atgctgctcg atgtgatcat gatcaaagtc actcatcaaa aagagaccaa gagcttgctt     60

tccagggcac agtagataaa tgtcgtcact tacaggaaaa tttgaattct catgttctga    120

ttctttctct gcaactttct aaagctgaga gtaagtccag agtcctcaaa actgagctcc    180

attacacagg agaggctctg aaagaaaagg ctttggtttt tgaacacgtg caaagtgagc    240

taaagcaaaa acagagtcaa atgaaggaca ttgaaaaaat gtacaaaagt ggatacaata    300

caatggaaaa atgcatagaa aaacaggaaa gattttgtca actaaaaaaa caaaatatgt    360

tgcttcaaca gcaactggat gatgctcgca acaaagctga caatcaagaa aaagcaatac    420

ttaatattca agccagatgt gatgctagag tacaaaacct tcaagctgag tgcagaaagc    480

accgtctttt actagaagaa gacaataaaa tgttggtcaa tgaactgaat cattcgaaag    540

aaaaagaatg ccaatatgaa aaagagaaag cagaaagaga agtagctgtg agacagcttc    600

aacaaaaacg agatgatgtc ttaaacaaag gatcagcaac aaaagctctg ctggatgctt    660

catcgcgtca ctgcacctat ttagaaaatg ggatgcagga ttcaaggaag aaattagacc    720

agatgagaag tcaagcttga agtagaacat gtgatgatga gaaaaattat taaaaaacag    780

gatgaccaaa ttgagcggct tgagaaaatc ctgcagcatt caagtttgat gctgcaggtg    840

tttgagagct agatgaagca tccagccaaa ctagactaca tggagctcca cagtgatcgt    900

cttcacctcc agctgtttgc atttacttct tccctctatc ctacatgtgt tttccttccc    960

cttcagatat caacctatga attgcctcta ccaaaaagcc tacaatattg acacaaacct   1020

gggctagtat cccttctatg tcttccaata agtgctgtct tatgcttgtc attgtatgta   1080

tgactctgta tgggaattgc ctgtttgttt tttcagatta tagcatacag ttgttgaggg   1140

gcggaccgta tcatctttat cttgtaattc cagtgcttgt cctagtacct tagcacatgg   1200

ttgctgaata catgaacgaa gagtgagaaa ccagaagctc tgatacttaa ctgccatgat   1260

aatgaattcg gtgtgcaact atgggcaaat tatatttaat agtaattgca tattgtacat   1320

atttttcatt cttattaaca ctgataagct tttcagcata tactgacttt ctcttagtta   1380

actgtgaaat catttagata aagaatataa ttctttttca ttctaacttc tgaatttaaa   1440

tctgaatcct ctatagcagg ggtccccaac tcccaggcca cacacagttc catgacctgt   1500

taggaagcag gctgcacagc aggaggtgag tggcaggcaa gcgagtgaag cttcatctgt   1560

atttccagcc actccctgtt gctcacatta tcacctgagc tctgcctcct gtcagatcag   1620

caaagccatt agattctcac aggagtgaaa atcctactgt gaactgctcg ttcaagggat   1680

ctaggtcaca tgctccttat gagactctaa tgcctgatga tatgtcattg tctcctatct   1740

cttcacgatg ggaccatcta gttacagaaa aacaagctca ggactcccat tgattctcca   1800

ttatgatgag ttgtgtaatt atttcattat gtattacaat gtagtcataa taggaataaa   1860

gtgcacaata gatgtaatac gcttgaatca ccatcctgaa accatccccc aaacccccat   1920

ctgtggaaaa attatctttc acaaaactgc tgcctggtgc caaaaaggct ggggactgct   1980

gctctatagc ttctgcacta gaatctacta atgagtaaaa tttaaatcaa taactagttt   2040

taaaagcata acaagaatat gtgctgtctg gctgcagtgg ctcatgcctg tattctcagc   2100

actttgggag gccagtgcag gtggatcact tgaggtcagg agttcaagac cagcctggcc   2160

aatatggtga aatcctgtct ctactaaaaa tacaaaaatt agctgggtgt ggtggtgcat   2220

gcctgtagtc tcagctactc gggaggctga ggtgggagaa tcacttgaac ccgggaggca   2280

gaggtttcag tgagccaaga tcgtgccact gcactccagc ctgagcaaca gagtgactcc   2340

atctcaaatg caaaacaaaa cagaaagaat acatgctgac gaaaaaaatc taagacaata   2400

aaattgtatt actaggctgt taacatgata ttttgtttcc cgttaaatgt gtgacatgca   2460

aaagtattta ttaaatgaaa atatttttta tct                                2493


<210>  8046
<211>  159
<212>  PRT
<213>  Homosapiens

<400>  8046

Met Lys Asp Ile Glu Lys Met Tyr Lys Ser Gly Tyr Asn Thr Met Glu 
1               5                   10                  15      


Lys Cys Ile Glu Lys Gln Glu Arg Phe Cys Gln Leu Lys Lys Gln Asn 
            20                  25                  30          


Met Leu Leu Gln Gln Gln Leu Asp Asp Ala Arg Asn Lys Ala Asp Asn 
        35                  40                  45              


Gln Glu Lys Ala Ile Leu Asn Ile Gln Ala Arg Cys Asp Ala Arg Val 
    50                  55                  60                  


Gln Asn Leu Gln Ala Glu Cys Arg Lys His Arg Leu Leu Leu Glu Glu 
65                  70                  75                  80  


Asp Asn Lys Met Leu Val Asn Glu Leu Asn His Ser Lys Glu Lys Glu 
                85                  90                  95      


Cys Gln Tyr Glu Lys Glu Lys Ala Glu Arg Glu Val Ala Val Arg Gln 
            100                 105                 110         


Leu Gln Gln Lys Arg Asp Asp Val Leu Asn Lys Gly Ser Ala Thr Lys 
        115                 120                 125             


Ala Leu Leu Asp Ala Ser Ser Arg His Cys Thr Tyr Leu Glu Asn Gly 
    130                 135                 140                 


Met Gln Asp Ser Arg Lys Lys Leu Asp Gln Met Arg Ser Gln Ala 
145                 150                 155                 


<210>  8047
<211>  554
<212>  DNA
<213>  Homosapiens

<400>  8047
agatggaagg cgacacacaa aagtaaaatt tgaagcagca cacaaaataa cttgagtatt     60

tataaagcaa aagagcactg tagtatgaaa attgtatcag ttatgataat tagtatgtct    120

ttgtgaagcc aaaaaagttt catttgtaag ctatatcgaa atacatcatt tttctacatt    180

attcctaaat tttgcatatt atcaccaaaa cacaggtaga aaatgacaca gtagcccaat    240

cgtctacttt tgtgattgct aagaatttgt gtaattatac cttcagaagt ttgtttagaa    300

tttacatgat ttaaaaaaaa ttacgtgtga gagtaattat tttaaaatgc acattttagg    360

cttgaagtag aacatgtgat gatgagaaaa attattaaaa aacaggatga ccaaattgag    420

cggcttgaga aaatcctgca gcattcaagt ttgatgctgc aggtgtttga gagctagatg    480

aaggtatgtt gccaaaattt atgaattaaa ttcaaatcat tgatttctga aataaactct    540

aagtagtgaa cggt                                                      554


<210>  8048
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  8048

Met Met Arg Lys Ile Ile Lys Lys Gln Asp Asp Gln Ile Glu Arg Leu 
1               5                   10                  15      


Glu Lys Ile Leu Gln His Ser Ser Leu Met Leu Gln Val Phe Glu Ser 
            20                  25                  30          


<210>  8049
<211>  1000
<212>  DNA
<213>  Homosapiens

<400>  8049
atgctgctcg atgtgatcat gatcaaagtc actcatcaaa aagagaccaa gagcttgctt     60

tccagggcac agtagataaa tgtcgtcact tacaggaaaa tttgaattct catgttctga    120

ttctttctct gcaactttct aaagctgaga gtaagtccag agtcctcaaa actgagctcc    180

attacacagg agaggctctg aaagaaaagg ctttggtttt tgaacacgtg caaagtgagc    240

taaagcaaaa acagagtcaa atgaaggaca ttgaaaaaat gtacaaaagt ggatacaata    300

caatggaaaa atgcatagaa aaacaggaaa gattttgtca actaaaaaaa caaaatatgt    360

tgcttcaaca gcaactggat gatgctcgca acaaagctga caatcaagaa aaagcaatac    420

ttaatattca agccagatgt gatgctagag tacaaaacct tcaagctgag tgcagaaagc    480

accgtctttt actagaagaa gacaataaaa tgttggtcaa tgaactgaat cattcgaaag    540

aaaaagaatg ccaatatgaa aaagagaaag cagaaagaga agtagctgtg agacagcttc    600

aacaaaaacg agatgatgtc ttaaacaaag gatcagcaac aaaagctctg ctggatgctt    660

catcgcgtca ctgcacctat ttagaaaatg ggatgcagga ttcaaggaag aaattagacc    720

agatgagaag tcaatttcaa gaaatacagg atcaacttac agctactata agatgtacta    780

aggagatgga aggcgacaca caaaagcttg aagtagaaca tgtgatgatg agaaaaatta    840

ttaaaaaaca ggatgaccaa attgagcggc ttgagaaaat cctgcagcat tcaagtttga    900

tgctgcaggt gtttgagagc tagatgaagg tatgttgcca aaatttatga attaaattca    960

aatcattgat ttctgaaata aactctaagt agtgaacggt                         1000


<210>  8050
<211>  220
<212>  PRT
<213>  Homosapiens

<400>  8050

Met Lys Asp Ile Glu Lys Met Tyr Lys Ser Gly Tyr Asn Thr Met Glu 
1               5                   10                  15      


Lys Cys Ile Glu Lys Gln Glu Arg Phe Cys Gln Leu Lys Lys Gln Asn 
            20                  25                  30          


Met Leu Leu Gln Gln Gln Leu Asp Asp Ala Arg Asn Lys Ala Asp Asn 
        35                  40                  45              


Gln Glu Lys Ala Ile Leu Asn Ile Gln Ala Arg Cys Asp Ala Arg Val 
    50                  55                  60                  


Gln Asn Leu Gln Ala Glu Cys Arg Lys His Arg Leu Leu Leu Glu Glu 
65                  70                  75                  80  


Asp Asn Lys Met Leu Val Asn Glu Leu Asn His Ser Lys Glu Lys Glu 
                85                  90                  95      


Cys Gln Tyr Glu Lys Glu Lys Ala Glu Arg Glu Val Ala Val Arg Gln 
            100                 105                 110         


Leu Gln Gln Lys Arg Asp Asp Val Leu Asn Lys Gly Ser Ala Thr Lys 
        115                 120                 125             


Ala Leu Leu Asp Ala Ser Ser Arg His Cys Thr Tyr Leu Glu Asn Gly 
    130                 135                 140                 


Met Gln Asp Ser Arg Lys Lys Leu Asp Gln Met Arg Ser Gln Phe Gln 
145                 150                 155                 160 


Glu Ile Gln Asp Gln Leu Thr Ala Thr Ile Arg Cys Thr Lys Glu Met 
                165                 170                 175     


Glu Gly Asp Thr Gln Lys Leu Glu Val Glu His Val Met Met Arg Lys 
            180                 185                 190         


Ile Ile Lys Lys Gln Asp Asp Gln Ile Glu Arg Leu Glu Lys Ile Leu 
        195                 200                 205             


Gln His Ser Ser Leu Met Leu Gln Val Phe Glu Ser 
    210                 215                 220 


<210>  8051
<211>  5529
<212>  DNA
<213>  Homosapiens

<400>  8051
ccttctgttg ggcgtttctg cggagaggcg ggaggcgctg agagtctgcg cggaggtccg     60

tgcacagact gctttgcctg ttgttgctct tcggaggcgg cgatccccga aggcgagctg    120

aaatacggct gcaggctaca atttgcagcc gacgattaag gaagacgacg agcgggagag    180

gtggcccacc ctcatggagc gcttgtgctc ggatggcttc gcatttcccc attactacat    240

taaaccgtat catctgaaga ggatccacag agctgtctta cgtggtaatc tggagaaact    300

gaagtacctt ctgctcacgt attatgacgc caataagaga gacaggaagg aaaggactgc    360

cctacatttg gcctgtgcca ctggccaacc ggaaatggta catctcctgg tgtccagaag    420

atgtgagctt aacctctgcg accgtgaaga caggacacct ctgatcaagg ctgtacaact    480

gaggcaggag gcttgtgcaa ctcttctgct gcaaaatggc gccgatccaa atattacgga    540

tgtctttgga aggactgctc tgcactacgc tgtgtataat gaagatacat ccatgataga    600

aaaacttctt tcacatggta caaatattga agaatgcagc aagaatgaat atcagccact    660

gttacttgct gtgagtcgaa gaaaagtgaa aatggtggaa tttttattaa agaaaaaagc    720

aaatgtaaat gccattgatt atcttggcag atcagccctc atacttgctg ttactcttgg    780

agaaaaagat atagtcattc ttcttctgca gcacaatatt gatgtgtttt ctcgagatgt    840

gtatggaaag cttgcagaag attatgccat gtctcctcag aaacaacgag ctgagaaggc    900

tacaagtgac gacaaagatt ctgtttcaaa tatagccaca gaaataaagg agggacctat    960

atctgggaca gtgtcttctc agaaacaacc agctgagaag gctacaagtg acgagaaaga   1020

ttctgtttca aatatagcca cagaaataaa ggagggacaa caatctggga cagtgtcttc   1080

tcagaaacaa ccagcctcaa agactgcaag tgacaagaca gattctgctt tgaatacagc   1140

tacagaaata aaggatggac tacaatgtgg gacagtgtct tctcagaaac aacaagcctt   1200

gaaggctaca actgacgagg aaggttctgt ttctaatata gccacagaaa taaaggatgg   1260

agaaaaatct gggacagtgt cttctcagaa aaaaccagcc ttgaaggcca caagtgatga   1320

gaaagattct ttttcgaata taaccagaga aaaaaaggat ggagaaatat ctaggacagt   1380

gtcttctcag aaaccaccag ccttgaaggc tacaagtgtc aaggaagatt ctgttttgaa   1440

tatagccaga gaaaaaaagg atggagaaaa atctaggaca gtgtcttctc ataaacaacc   1500

atccttgaag gctacaagtg acaaggaaga ttctgttccg aatatggcca cagaaacaaa   1560

ggatgaacaa atatctggga cagaacaaga cttagaaatg gcatcagagg gagagcaaaa   1620

gaggcttgaa gaatatgaaa ataaccagcc acaggtgaaa aaccaaatac attctaggga   1680

tgaccttgat gacataattc agtcatctca aacagtctca gaggacggtg actcgctttg   1740

ctgtaattgt aagaatgtca tattactcat tgatcaacat gaaatgaagt gtaaagattg   1800

tgttcaccta ttgaaaatta aaaatacatt ttgtttatgg aaaagattaa taaaacttaa   1860

agataaccac tgtgagcaac ttagagtaaa aattcgaaaa ctgaaaaata aggctagtgt   1920

actacaaaag agaatatctg aaaaagaaga aataaaatcg cagttaaagc atgaaatact   1980

tgaattggaa aaagaactct gtagtttgag atttgccata cagcaagaaa aaaagaaaag   2040

aagaaatgtt gaagagttgc accaaaaagt tagggaaaag ttaagaataa cagaagagca   2100

atataggata gaagctgatg tgacaaaacc aattaaaccg gctctcaaat cagcagaggt   2160

ggaattgaag acaggaggaa ataattcaaa tcaggtttct gaaactgatg aaaaagaaga   2220

cctgctgcat gaaaaccgct tgatgcaaga tgaaattgcc aggctcaggc tggaaaaaga   2280

cacaataaaa aaccaaaacc tggaaaagaa atacttaaaa gactttgaaa ttgtgaaaag   2340

aaagcatgaa gaccttcaaa aggctctaaa acggaatggg gaaacattag caaaaacgat   2400

agcctgttat agtggacagc ttgctgctct gacagatgaa aacacaacgc tccgttccaa   2460

actggagaag caaagagaga gcaggcaaag actggaaaca gaaatgcaat cataccgttg   2520

tagactgaat gctgctcgat gtgatcatga tcaaagtcac tcatcaaaaa gagaccaaga   2580

gcttgctttc cagggcacag tagataaatg tcgtcactta caggaaaatt tgaattctca   2640

tgttctgatt ctttctctgc aactttctaa agctgagagt aagtccagag tcctcaaaac   2700

tgagctccat tacacaggag aggctctgaa agaaaaggct ttggtttttg aacacgtgca   2760

aagtgagcta aagcaaaaac agagtcaaat gaaggacatt gaaaaaatgt acaaaagtgg   2820

atacaataca atggaaaaat gcatagaaaa acaggaaaga ttttgtcaac taaaaaaaca   2880

aaatatgttg cttcaacagc aactggatga tgctcgcaac aaagctgaca atcaagaaaa   2940

agcaatactt aatattcaag ccagatgtga tgctagagta caaaaccttc aagctgagtg   3000

cagaaagcac cgtcttttac tagaagaaga caataaaatg ttggtcaatg aactgaatca   3060

ttcgaaagaa aaagaatgcc aatatgaaaa agagaaagca gaaagagaag tagctgtgag   3120

acagcttcaa caaaaacgag atgatgtctt aaacaaagga tcagcaacaa aagctctgct   3180

ggatgcttca tcgcgtcact gcacctattt agaaaatggg atgcaggatt caaggaagaa   3240

attagaccag atgagaagtc aagtatgtat gcaactttgc acaccaacaa ctgttaatct   3300

gtagctagtt aactaatata aagtgttttg gggtactaat tttagtggat ggctttcttt   3360

tgtattttta tgataattaa tgttattaaa attttatagt ggatggcttt cttctgtatt   3420

ttccttatta ttaattttat taagatttta ttataatgca cctatatctt aatctctggc   3480

tttcattctg ccatttttta tacatatatt tttttcttaa atatttaacc ttaggaaagt   3540

tgagaattat gcatcatttc tcacagaagt tgagagagtt tttttttcct gttaaacagt   3600

ctatttttaa tgatttctct attggcatgg tgaggcaagc caggttaatt cagaggataa   3660

tgtctaatgg aatgtttcag aaaattatct tctttttagt ctctactttt ctgaatgtat   3720

aaagaacctg tgtatacgta tttcttagat ttcaggttaa cttgttcaga aaggccattt   3780

tactgaataa atttttattt cgatgaaaat ccttacttcc tttgtattgg gctcagagag   3840

cacactctgt ctctatatga atatggacag ttagcatttg ccaacatgta tctattttct   3900

cttatttgta gaaaaagcta aactaaaaag ggggttatag aaggtcagca aaggatgggt   3960

ttgagatgtt tgggttggtt aagtgggcat ttagacaaca gggcttctcc tttggcatgt   4020

ttaatggaca tctttgcagt ttaagatgac gcttttaaat tacttctctc ctaatgatga   4080

cctgagtcct gctattcaat gggagagtca ataagatcct gtaggatctt atttggaact   4140

gactttgtcg attttaattt tgttcctgct tgtttttaaa ttttcttgtt gtttccctag   4200

aaaggaaaga tgatgcttag ttttaaatat ttaaaaatgt gcaagttgct ttgctataat   4260

aaaactaaat gcatacatac aaaaaataaa attatagttg atgtggtagt gtttggaatt   4320

caaaatataa atgcttagcg tgaggtaatc ctttatcttt ccacatttta ccagtttgta   4380

agtttgagta tttaattgat aaaatgtaat tcaaaagcaa gaagaatgtt gtgttttagt   4440

cctagagcag gggtctgtga acttttctgt aaagggccag atagtattat gtaaggcttt   4500

gtgagccata agatccttgt tgcaataact cggccctgca attacagcac aaaagtagcc   4560

atgaacaata tgcagactga aggggtgtag cagtgtccca ctaaaattac ttacaaaaaa   4620

caggtaatgg gatgatttct cctagattat gaccttttat aaataaaaaa gattgtgata   4680

gtctaaaata tttcatatat attttgttga ttcattcatc tactgatgga catttaggtc   4740

atttccaaat gtaatttttt aaaattcttt gtttcagttt caagaaatac aggatcaact   4800

tacagctact ataagatgta ctaaggagat ggaaggcgac acacaaaagt aaaatttgaa   4860

gcagcacaca aaataacttg agtatttata aagcaaaaga gcactgtagt atgaaaattg   4920

tatcagttat gataattagt atgtctttgt gaagccaaaa aagtttcatt tgtaagctat   4980

atcgaaatac atcatttttc tacattattc ctaaattttg catattatca ccaaaacaca   5040

ggtagaaaat gacacagtag cccaatcgtc tacttttgtg attgctaaga atttgtgtaa   5100

ttataccttc agaagtttgt ttagaattta catgatttaa aaaaaattac gtgtgagagt   5160

aattatttta aaatgcacat tttaggcttg aagtagaaca tgtgatgatg agaaaaatta   5220

ttaaaaaaca ggatgaccaa attgagcggc ttgagaaaat cctgcagcat tcaagtttgg   5280

taagctgatc tcttaatttc tgtcatactg aaaaggaatt ttatttttcc agtaggatgg   5340

gttaaatatc ccttgtccaa aatgcttggg accaaaagta gatttttttc agattttgga   5400

atatttgtat atacctaatg aaatatcttg cggatggtac ctgagtctaa acatgaaatt   5460

catttgtgtt tcatatatac cttatgcaca tagcctgaag gtaattctct acaatgtttt   5520

acagtaatt                                                           5529


<210>  8052
<211>  1036
<212>  PRT
<213>  Homosapiens

<400>  8052

Met Glu Arg Leu Cys Ser Asp Gly Phe Ala Phe Pro His Tyr Tyr Ile 
1               5                   10                  15      


Lys Pro Tyr His Leu Lys Arg Ile His Arg Ala Val Leu Arg Gly Asn 
            20                  25                  30          


Leu Glu Lys Leu Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys 
        35                  40                  45              


Arg Asp Arg Lys Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly 
    50                  55                  60                  


Gln Pro Glu Met Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn 
65                  70                  75                  80  


Leu Cys Asp Arg Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu 
                85                  90                  95      


Arg Gln Glu Ala Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asp Pro 
            100                 105                 110         


Asn Ile Thr Asp Val Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr 
        115                 120                 125             


Asn Glu Asp Thr Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn 
    130                 135                 140                 


Ile Glu Glu Cys Ser Lys Asn Glu Tyr Gln Pro Leu Leu Leu Ala Val 
145                 150                 155                 160 


Ser Arg Arg Lys Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala 
                165                 170                 175     


Asn Val Asn Ala Ile Asp Tyr Leu Gly Arg Ser Ala Leu Ile Leu Ala 
            180                 185                 190         


Val Thr Leu Gly Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn 
        195                 200                 205             


Ile Asp Val Phe Ser Arg Asp Val Tyr Gly Lys Leu Ala Glu Asp Tyr 
    210                 215                 220                 


Ala Met Ser Pro Gln Lys Gln Arg Ala Glu Lys Ala Thr Ser Asp Asp 
225                 230                 235                 240 


Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Glu Gly Pro Ile 
                245                 250                 255     


Ser Gly Thr Val Ser Ser Gln Lys Gln Pro Ala Glu Lys Ala Thr Ser 
            260                 265                 270         


Asp Glu Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Glu Gly 
        275                 280                 285             


Gln Gln Ser Gly Thr Val Ser Ser Gln Lys Gln Pro Ala Ser Lys Thr 
    290                 295                 300                 


Ala Ser Asp Lys Thr Asp Ser Ala Leu Asn Thr Ala Thr Glu Ile Lys 
305                 310                 315                 320 


Asp Gly Leu Gln Cys Gly Thr Val Ser Ser Gln Lys Gln Gln Ala Leu 
                325                 330                 335     


Lys Ala Thr Thr Asp Glu Glu Gly Ser Val Ser Asn Ile Ala Thr Glu 
            340                 345                 350         


Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser Ser Gln Lys Lys Pro 
        355                 360                 365             


Ala Leu Lys Ala Thr Ser Asp Glu Lys Asp Ser Phe Ser Asn Ile Thr 
    370                 375                 380                 


Arg Glu Lys Lys Asp Gly Glu Ile Ser Arg Thr Val Ser Ser Gln Lys 
385                 390                 395                 400 


Pro Pro Ala Leu Lys Ala Thr Ser Val Lys Glu Asp Ser Val Leu Asn 
                405                 410                 415     


Ile Ala Arg Glu Lys Lys Asp Gly Glu Lys Ser Arg Thr Val Ser Ser 
            420                 425                 430         


His Lys Gln Pro Ser Leu Lys Ala Thr Ser Asp Lys Glu Asp Ser Val 
        435                 440                 445             


Pro Asn Met Ala Thr Glu Thr Lys Asp Glu Gln Ile Ser Gly Thr Glu 
    450                 455                 460                 


Gln Asp Leu Glu Met Ala Ser Glu Gly Glu Gln Lys Arg Leu Glu Glu 
465                 470                 475                 480 


Tyr Glu Asn Asn Gln Pro Gln Val Lys Asn Gln Ile His Ser Arg Asp 
                485                 490                 495     


Asp Leu Asp Asp Ile Ile Gln Ser Ser Gln Thr Val Ser Glu Asp Gly 
            500                 505                 510         


Asp Ser Leu Cys Cys Asn Cys Lys Asn Val Ile Leu Leu Ile Asp Gln 
        515                 520                 525             


His Glu Met Lys Cys Lys Asp Cys Val His Leu Leu Lys Ile Lys Asn 
    530                 535                 540                 


Thr Phe Cys Leu Trp Lys Arg Leu Ile Lys Leu Lys Asp Asn His Cys 
545                 550                 555                 560 


Glu Gln Leu Arg Val Lys Ile Arg Lys Leu Lys Asn Lys Ala Ser Val 
                565                 570                 575     


Leu Gln Lys Arg Ile Ser Glu Lys Glu Glu Ile Lys Ser Gln Leu Lys 
            580                 585                 590         


His Glu Ile Leu Glu Leu Glu Lys Glu Leu Cys Ser Leu Arg Phe Ala 
        595                 600                 605             


Ile Gln Gln Glu Lys Lys Lys Arg Arg Asn Val Glu Glu Leu His Gln 
    610                 615                 620                 


Lys Val Arg Glu Lys Leu Arg Ile Thr Glu Glu Gln Tyr Arg Ile Glu 
625                 630                 635                 640 


Ala Asp Val Thr Lys Pro Ile Lys Pro Ala Leu Lys Ser Ala Glu Val 
                645                 650                 655     


Glu Leu Lys Thr Gly Gly Asn Asn Ser Asn Gln Val Ser Glu Thr Asp 
            660                 665                 670         


Glu Lys Glu Asp Leu Leu His Glu Asn Arg Leu Met Gln Asp Glu Ile 
        675                 680                 685             


Ala Arg Leu Arg Leu Glu Lys Asp Thr Ile Lys Asn Gln Asn Leu Glu 
    690                 695                 700                 


Lys Lys Tyr Leu Lys Asp Phe Glu Ile Val Lys Arg Lys His Glu Asp 
705                 710                 715                 720 


Leu Gln Lys Ala Leu Lys Arg Asn Gly Glu Thr Leu Ala Lys Thr Ile 
                725                 730                 735     


Ala Cys Tyr Ser Gly Gln Leu Ala Ala Leu Thr Asp Glu Asn Thr Thr 
            740                 745                 750         


Leu Arg Ser Lys Leu Glu Lys Gln Arg Glu Ser Arg Gln Arg Leu Glu 
        755                 760                 765             


Thr Glu Met Gln Ser Tyr Arg Cys Arg Leu Asn Ala Ala Arg Cys Asp 
    770                 775                 780                 


His Asp Gln Ser His Ser Ser Lys Arg Asp Gln Glu Leu Ala Phe Gln 
785                 790                 795                 800 


Gly Thr Val Asp Lys Cys Arg His Leu Gln Glu Asn Leu Asn Ser His 
                805                 810                 815     


Val Leu Ile Leu Ser Leu Gln Leu Ser Lys Ala Glu Ser Lys Ser Arg 
            820                 825                 830         


Val Leu Lys Thr Glu Leu His Tyr Thr Gly Glu Ala Leu Lys Glu Lys 
        835                 840                 845             


Ala Leu Val Phe Glu His Val Gln Ser Glu Leu Lys Gln Lys Gln Ser 
    850                 855                 860                 


Gln Met Lys Asp Ile Glu Lys Met Tyr Lys Ser Gly Tyr Asn Thr Met 
865                 870                 875                 880 


Glu Lys Cys Ile Glu Lys Gln Glu Arg Phe Cys Gln Leu Lys Lys Gln 
                885                 890                 895     


Asn Met Leu Leu Gln Gln Gln Leu Asp Asp Ala Arg Asn Lys Ala Asp 
            900                 905                 910         


Asn Gln Glu Lys Ala Ile Leu Asn Ile Gln Ala Arg Cys Asp Ala Arg 
        915                 920                 925             


Val Gln Asn Leu Gln Ala Glu Cys Arg Lys His Arg Leu Leu Leu Glu 
    930                 935                 940                 


Glu Asp Asn Lys Met Leu Val Asn Glu Leu Asn His Ser Lys Glu Lys 
945                 950                 955                 960 


Glu Cys Gln Tyr Glu Lys Glu Lys Ala Glu Arg Glu Val Ala Val Arg 
                965                 970                 975     


Gln Leu Gln Gln Lys Arg Asp Asp Val Leu Asn Lys Gly Ser Ala Thr 
            980                 985                 990         


Lys Ala Leu Leu Asp Ala Ser Ser  Arg His Cys Thr Tyr  Leu Glu Asn 
        995                 1000                 1005             


Gly Met  Gln Asp Ser Arg Lys  Lys Leu Asp Gln Met  Arg Ser Gln 
    1010                 1015                 1020             


Val Cys  Met Gln Leu Cys Thr  Pro Thr Thr Val Asn  Leu 
    1025                 1030                 1035     


<210>  8053
<211>  963
<212>  DNA
<213>  Homosapiens

<400>  8053
atgctgctcg atgtgatcat gatcaaagtc actcatcaaa aagagaccaa gagcttgctt     60

tccagggcac agtagataaa tgtcgtcact tacaggaaaa tttgaattct catgttctga    120

ttctttctct gcaactttct aaagctgaga gtaagtccag agtcctcaaa actgagctcc    180

attacacagg agaggctctg aaagaaaagg ctttggtttt tgaacacgtg caaagtgagc    240

taaagcaaaa acagagtcaa atgaaggaca ttgaaaaaat gtacaaaagt ggatacaata    300

caatggaaaa atgcatagaa aaacaggaaa gattttgtca actaaaaaaa caaaatatgt    360

tgcttcaaca gcaactggat gatgctcgca acaaagctga caatcaagaa aaagcaatac    420

ttaatattca agccagatgt gatgctagag tacaaaacct tcaagctgag tgcagaaagc    480

accgtctttt actagaagaa gacaataaaa tgttggtcaa tgaactgaat cattcgaaag    540

aaaaagaatg ccaatatgaa aaagagaaag cagaaagaga agtagctgtg agacagcttc    600

aacaaaaacg agatgatgtc ttaaacaaag gatcagcaac aaaagctctg ctggatgctt    660

catcgcgtca ctgcacctat ttagaaaatg ggatgcagga ttcaaggaag aaattagacc    720

agatgagaag tcaatttcaa gaaatacagg atcaacttac agctactata agatgtacta    780

aggagatgga aggcgacaca caaaagtaaa atttgaagca gcacacaaaa taacttgagt    840

atttataaag caaaagagca ctgtagtatg aaaattgtat cagttatgat aattagtatg    900

tctttgtgaa gccaaaaaag tttcatttgt aagctatatc gaaatacatc atttttctac    960

att                                                                  963


<210>  8054
<211>  182
<212>  PRT
<213>  Homosapiens

<400>  8054

Met Lys Asp Ile Glu Lys Met Tyr Lys Ser Gly Tyr Asn Thr Met Glu 
1               5                   10                  15      


Lys Cys Ile Glu Lys Gln Glu Arg Phe Cys Gln Leu Lys Lys Gln Asn 
            20                  25                  30          


Met Leu Leu Gln Gln Gln Leu Asp Asp Ala Arg Asn Lys Ala Asp Asn 
        35                  40                  45              


Gln Glu Lys Ala Ile Leu Asn Ile Gln Ala Arg Cys Asp Ala Arg Val 
    50                  55                  60                  


Gln Asn Leu Gln Ala Glu Cys Arg Lys His Arg Leu Leu Leu Glu Glu 
65                  70                  75                  80  


Asp Asn Lys Met Leu Val Asn Glu Leu Asn His Ser Lys Glu Lys Glu 
                85                  90                  95      


Cys Gln Tyr Glu Lys Glu Lys Ala Glu Arg Glu Val Ala Val Arg Gln 
            100                 105                 110         


Leu Gln Gln Lys Arg Asp Asp Val Leu Asn Lys Gly Ser Ala Thr Lys 
        115                 120                 125             


Ala Leu Leu Asp Ala Ser Ser Arg His Cys Thr Tyr Leu Glu Asn Gly 
    130                 135                 140                 


Met Gln Asp Ser Arg Lys Lys Leu Asp Gln Met Arg Ser Gln Phe Gln 
145                 150                 155                 160 


Glu Ile Gln Asp Gln Leu Thr Ala Thr Ile Arg Cys Thr Lys Glu Met 
                165                 170                 175     


Glu Gly Asp Thr Gln Lys 
            180         


<210>  8055
<211>  440
<212>  DNA
<213>  Homosapiens

<400>  8055
cagtgtcttc tcagaaacaa caagccttga aggctacaac tgacgaggaa ggttctgttt     60

ctaatatagc cacagaaata aaggatggag aaaaatctgg gacagtgtct tctcagaaaa    120

aaccagcctt gaaggccaca agtgatgaga aagattcttt ttcgaatata accagagaaa    180

aaaaggatgg agaaatatct aggacaggta attttgcgaa acacatttaa tgtcatgttc    240

agtccagata agaagttctc ttccccgaat aaatcagtgg ggggctggtc gaagctgcac    300

attctgactc agcaggcctg agattcttca tttctaataa gttcttgggt tatgctgata    360

ctgctggtct ggaatatgat cttggctgta agattataca catccccaca ttgcaactgg    420

gaggaagaaa tatagagagc                                                440


<210>  8056
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  8056

Met Glu Lys Tyr Leu Gly Gln Val Ile Leu Arg Asn Thr Phe Asn Val 
1               5                   10                  15      


Met Phe Ser Pro Asp Lys Lys Phe Ser Ser Pro Asn Lys Ser Val Gly 
            20                  25                  30          


Gly Trp Ser Lys Leu His Ile Leu Thr Gln Gln Ala 
        35                  40                  


<210>  8057
<211>  1221
<212>  DNA
<213>  Homosapiens

<400>  8057
ccttctgttg ggcgtttctg cggagaggcg ggaggcgctg agagtctgcg cggaggtccg     60

tgcacagact gctttgcctg ttgttgctct tcggaggcgg cgatccccga aggcgagctg    120

aaatacggct gcaggctaca atttgcagcc gacgattaag gaagacgacg agcgggagag    180

gtggcccacc ctcatggagc gcttgtgctc ggatggcttc gcatttcccc attactacat    240

taaaccgtat catctgaaga ggatccacag agctgtctta cgtggtaatc tggagaaact    300

gaagtacctt ctgctcacgt attatgacgc caataagaga gacaggaagg aaaggactgc    360

cctacatttg gcctgtgcca ctggccaacc ggaaatggta catctcctgg tgtccagaag    420

atgtgagctt aacctctgcg accgtgaaga caggacacct ctgatcaagg ctgtacaact    480

gaggcaggag gcttgtgcaa ctcttctgct gcaaaatggc gccgatccaa atattacgga    540

tgtctttgga aggactgctc tgcactacgc tgtgtataat gaagatacat ccatgataga    600

aaaacttctt tcacatggta caaatattga agaatgcagc aagtgtctcc tcagaaacaa    660

cgagctgaga aggctacaag tgacgacaaa gattctgttt caaatatagc cacagaaata    720

aaggagggac ctatatctgg gacagtgtct tctcagaaac aaccagctga gaaggctaca    780

agtgacgaga aagattctgt ttcaaatata gccacagaaa taaaggaggg acaacaatct    840

gggacagtgt ctcctcagaa acaatcggcc cagaaggtta tatttaaaaa gaaagtttct    900

cttttgaata ttgccacaag aataatgggc ggtgggaaat ctggaacagt gtcttctcag    960

aaacaaccag cctcaaagac tgcaagtgac aagacagatt ctgctttgaa tacagctaca   1020

gaaataaagg atggactaca atgtgggaca gtgtcttctc agaaacaaca agccttgaag   1080

gctacaactg acgaggaagg ttctgtttct aatatagcca cagaaataaa ggatggagaa   1140

aaatctggga cagtgtcttc tcagaaaaaa ccagccttga aggccacaag tgatgagaaa   1200

gattcttttt cgaatataac c                                             1221


<210>  8058
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  8058

Met Gln Gln Val Ser Pro Gln Lys Gln Arg Ala Glu Lys Ala Thr Ser 
1               5                   10                  15      


Asp Asp Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Glu Gly 
            20                  25                  30          


Pro Ile Ser Gly Thr Val Ser Ser Gln Lys Gln Pro Ala Glu Lys Ala 
        35                  40                  45              


Thr Ser Asp Glu Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys 
    50                  55                  60                  


Glu Gly Gln Gln Ser Gly Thr Val Ser Pro Gln Lys Gln Ser Ala Gln 
65                  70                  75                  80  


Lys Val Ile Phe Lys Lys Lys Val Ser Leu Leu Asn Ile Ala Thr Arg 
                85                  90                  95      


Ile Met Gly Gly Gly Lys Ser Gly Thr Val Ser Ser Gln Lys Gln Pro 
            100                 105                 110         


Ala Ser Lys Thr Ala Ser Asp Lys Thr Asp Ser Ala Leu Asn Thr Ala 
        115                 120                 125             


Thr Glu Ile Lys Asp Gly Leu Gln Cys Gly Thr Val Ser Ser Gln Lys 
    130                 135                 140                 


Gln Gln Ala Leu Lys Ala Thr Thr Asp Glu Glu Gly Ser Val Ser Asn 
145                 150                 155                 160 


Ile Ala Thr Glu Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser Ser 
                165                 170                 175     


Gln Lys Lys Pro Ala Leu Lys Ala Thr Ser Asp Glu Lys Asp Ser Phe 
            180                 185                 190         


Ser Asn Ile 
        195 


<210>  8059
<211>  1050
<212>  DNA
<213>  Homosapiens

<400>  8059
gagaggcggg aggcgctgag agtctgcgcg gaggtccgtg cacagactgc tttgcctgtt     60

gttgctcttc ggaggcggcg atccccgaag gcgagctgaa atacggctgc aggctacaat    120

ttgcagccga cgattaagga agacgacgag cgggagaggt ggcccaccct catggagcgc    180

ttgtgctcgg atggcttcgc atttccccat tactacatta aaccgtatca tctgaagagg    240

atccacagag ctgtcttacg tggtaatctg gagaaactga agtaccttct gctcacgtat    300

tatgacgcca ataagagaga caggaaggaa aggactgccc tacatttggc ctgtgccact    360

ggccaaccgg aaatggtaca tctcctggtg tccagaagat gtgagcttaa cctctgcgac    420

cgtgaagaca ggacacctct gatcaaggct gtacaactga ggcaggaggc ttgtgcaact    480

cttctgctgc aaaatggcgc cgatccaaat attacggatg tctttggaag gactgctctg    540

cactacgctg tgtataatga agatacatcc atgatagaaa aacttctttc acatggtaca    600

aatattgaag aatgcagcaa ggtataggtc aaccaatgtt attttcaaac tatctgaaat    660

gcatttattt taacattgac acatgtaagg gtcaattttt catatttgga agctcaaaca    720

ttccttgaat gaaaatattt tgaaatgcct taactgtcta agattttact ttaaatattg    780

gaacttttaa agaagcatta tagggaacag ccttttttca tgcacttatg gtaaataact    840

ataaaaacaa atgaattaca ataaatttat aattcatgac aactgaattt gggaaaggta    900

atagttaagt gtttttccac taaattactt tttttctaat cagtgtgaag tgacacagga    960

aagtaaaatt gtcccttata aataggcttt attttaaatg tcaaagaaaa ttaaagaatt   1020

tcacaataaa tgtacatgtt gttgctgttg                                    1050


<210>  8060
<211>  151
<212>  PRT
<213>  Homosapiens

<400>  8060

Met Glu Arg Leu Cys Ser Asp Gly Phe Ala Phe Pro His Tyr Tyr Ile 
1               5                   10                  15      


Lys Pro Tyr His Leu Lys Arg Ile His Arg Ala Val Leu Arg Gly Asn 
            20                  25                  30          


Leu Glu Lys Leu Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys 
        35                  40                  45              


Arg Asp Arg Lys Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly 
    50                  55                  60                  


Gln Pro Glu Met Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn 
65                  70                  75                  80  


Leu Cys Asp Arg Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu 
                85                  90                  95      


Arg Gln Glu Ala Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asp Pro 
            100                 105                 110         


Asn Ile Thr Asp Val Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr 
        115                 120                 125             


Asn Glu Asp Thr Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn 
    130                 135                 140                 


Ile Glu Glu Cys Ser Lys Val 
145                 150     


<210>  8061
<211>  1145
<212>  DNA
<213>  Homosapiens

<400>  8061
cagacatctt gaggttactg gaatgcatgg agaataatct cccatatgat gacaacggca     60

cgttcagctc aactcagtca cacatggact ggggaaaagt agcttttaaa aacttttctg    120

gtgaaatgtg cagactcaaa tggttagaga tttcttgcag cttgagaaaa ttcagcactt    180

tgaaaaaatt agtcctggaa gctaagaaat gtgttaaaaa tacaaacaaa agccaaaaag    240

gcaggaacca tccagacttt ccaaagaggc tccttactgc ttatatccgc ttcttcaagg    300

agaattggcc ccagtactcc caaatgtacc ctgggatgag aagccaggaa gtgaccaaaa    360

tcctgtcaaa gaaatacaag gagctcccag agcagatgaa acagaaacat attcaggatt    420

tccggaagga aaagcaagaa tttgaggaaa aacttgctcg attcagggaa gaacaccctg    480

atttagacca gaagggcaag aaatctgata tctgcaagag ggttcaaacc aaagtgcaaa    540

agaaggttca gaaaaatatt gaagaagtga ggtctcttcc aaaaacggat caatttttca    600

agaaggtaaa atttcatgga gagcctcaga aaccccccat gaatggatac cagaagtttc    660

accaagattc ctggtcaagt aaggagctgc aacatttgtc cctgagggag cgcatggtag    720

agattggcag acgctggcag cgcatcccgc agagccagaa ggatcattac aagagccagg    780

ctgagttgct gcagaaggaa tacaaagtgg aattggatct ctggctcaag actttgtcac    840

ctgaagatta tgctgcatac aaagaatcga cctatgctaa gggtaagaat atggcgatga    900

tgggaggccc ggcccccagc ttgaaacaaa cagatccgca gtcctcatca gcaaagggtc    960

tgcaagaagg gtttggggag gggcaggggc tccaggctgc aggaacagag gcatcacaga   1020

ctatttgggt aaactgtcag gtctctatgg aaccagaaga caacaggaag aaagatggcg   1080

aagaggaaga aagcagtaac tctttagact gcagcagtgg ggaagacatg gaagttgatg   1140

tctga                                                               1145


<210>  8062
<211>  372
<212>  PRT
<213>  Homosapiens

<400>  8062

Met Glu Asn Asn Leu Pro Tyr Asp Asp Asn Gly Thr Phe Ser Ser Thr 
1               5                   10                  15      


Gln Ser His Met Asp Trp Gly Lys Val Ala Phe Lys Asn Phe Ser Gly 
            20                  25                  30          


Glu Met Cys Arg Leu Lys Trp Leu Glu Ile Ser Cys Ser Leu Arg Lys 
        35                  40                  45              


Phe Ser Thr Leu Lys Lys Leu Val Leu Glu Ala Lys Lys Cys Val Lys 
    50                  55                  60                  


Asn Thr Asn Lys Ser Gln Lys Gly Arg Asn His Pro Asp Phe Pro Lys 
65                  70                  75                  80  


Arg Leu Leu Thr Ala Tyr Ile Arg Phe Phe Lys Glu Asn Trp Pro Gln 
                85                  90                  95      


Tyr Ser Gln Met Tyr Pro Gly Met Arg Ser Gln Glu Val Thr Lys Ile 
            100                 105                 110         


Leu Ser Lys Lys Tyr Lys Glu Leu Pro Glu Gln Met Lys Gln Lys His 
        115                 120                 125             


Ile Gln Asp Phe Arg Lys Glu Lys Gln Glu Phe Glu Glu Lys Leu Ala 
    130                 135                 140                 


Arg Phe Arg Glu Glu His Pro Asp Leu Asp Gln Lys Gly Lys Lys Ser 
145                 150                 155                 160 


Asp Ile Cys Lys Arg Val Gln Thr Lys Val Gln Lys Lys Val Gln Lys 
                165                 170                 175     


Asn Ile Glu Glu Val Arg Ser Leu Pro Lys Thr Asp Gln Phe Phe Lys 
            180                 185                 190         


Lys Val Lys Phe His Gly Glu Pro Gln Lys Pro Pro Met Asn Gly Tyr 
        195                 200                 205             


Gln Lys Phe His Gln Asp Ser Trp Ser Ser Lys Glu Leu Gln His Leu 
    210                 215                 220                 


Ser Leu Arg Glu Arg Met Val Glu Ile Gly Arg Arg Trp Gln Arg Ile 
225                 230                 235                 240 


Pro Gln Ser Gln Lys Asp His Tyr Lys Ser Gln Ala Glu Leu Leu Gln 
                245                 250                 255     


Lys Glu Tyr Lys Val Glu Leu Asp Leu Trp Leu Lys Thr Leu Ser Pro 
            260                 265                 270         


Glu Asp Tyr Ala Ala Tyr Lys Glu Ser Thr Tyr Ala Lys Gly Lys Asn 
        275                 280                 285             


Met Ala Met Met Gly Gly Pro Ala Pro Ser Leu Lys Gln Thr Asp Pro 
    290                 295                 300                 


Gln Ser Ser Ser Ala Lys Gly Leu Gln Glu Gly Phe Gly Glu Gly Gln 
305                 310                 315                 320 


Gly Leu Gln Ala Ala Gly Thr Glu Ala Ser Gln Thr Ile Trp Val Asn 
                325                 330                 335     


Cys Gln Val Ser Met Glu Pro Glu Asp Asn Arg Lys Lys Asp Gly Glu 
            340                 345                 350         


Glu Glu Glu Ser Ser Asn Ser Leu Asp Cys Ser Ser Gly Glu Asp Met 
        355                 360                 365             


Glu Val Asp Val 
    370         


<210>  8063
<211>  902
<212>  DNA
<213>  Homosapiens

<400>  8063
acgcagtgat ctttaggagc ccacttctaa attcaaatca tttggggttc agtaagtctc     60

ttcacagacg gggacctaat agcttccatt agcagcctcc acgtttgctg aacacgacta    120

cggggccaga cccacaggaa ctccaatgtg gttcagccgc tcaactccag ggaccaaaaa    180

gactttccca cctcccagcg ttattaaagg caaccccgcc cccaagcctc agccactacg    240

cggtgcagaa agaggcagag ctgggcatgc gcaatttccg cccccgccac agtcttggga    300

gtgggcgggc tcgagggctg ggaggaagcc gaaagctgac cgagaggaga aagaagcccg    360

cccccggaag tccctcctgt ctctgcagct tgttcccgga agttttgctg ctagtcgcgg    420

acgcaatggc ttcaaggtta cttcgcggag ctggaacgct ggccgcgcag gccctgaggg    480

ctcgcggccc cagtggcgcg gccgcgatgc gctccatggc atctggaggt ggtgttccca    540

ctgatgaaga gcaggcgact gggttggaga gggagatcat gctggctgca aagaagggac    600

tggacccata caatgtactg gccccaaagg gagcttcagg caccagggaa gaccctaatt    660

tagtcccctc catctccaac aagagaatag taggctgcat ctgtgaagag gacaatacca    720

gcgtcgtctg gttttggctg cacaaaggcg aggcccagcg atgcccccgc tgtggagccc    780

attacaagct ggtgccccag cagctggcac actgagcacc tgcactaaat tactcaaaat    840

gtgctgtaaa gtttcttctt tccagtaaag actagccatt gcattggctc cttctcccat    900

ag                                                                   902


<210>  8064
<211>  182
<212>  PRT
<213>  Homosapiens

<400>  8064

Met Arg Asn Phe Arg Pro Arg His Ser Leu Gly Ser Gly Arg Ala Arg 
1               5                   10                  15      


Gly Leu Gly Gly Ser Arg Lys Leu Thr Glu Arg Arg Lys Lys Pro Ala 
            20                  25                  30          


Pro Gly Ser Pro Ser Cys Leu Cys Ser Leu Phe Pro Glu Val Leu Leu 
        35                  40                  45              


Leu Val Ala Asp Ala Met Ala Ser Arg Leu Leu Arg Gly Ala Gly Thr 
    50                  55                  60                  


Leu Ala Ala Gln Ala Leu Arg Ala Arg Gly Pro Ser Gly Ala Ala Ala 
65                  70                  75                  80  


Met Arg Ser Met Ala Ser Gly Gly Gly Val Pro Thr Asp Glu Glu Gln 
                85                  90                  95      


Ala Thr Gly Leu Glu Arg Glu Ile Met Leu Ala Ala Lys Lys Gly Leu 
            100                 105                 110         


Asp Pro Tyr Asn Val Leu Ala Pro Lys Gly Ala Ser Gly Thr Arg Glu 
        115                 120                 125             


Asp Pro Asn Leu Val Pro Ser Ile Ser Asn Lys Arg Ile Val Gly Cys 
    130                 135                 140                 


Ile Cys Glu Glu Asp Asn Thr Ser Val Val Trp Phe Trp Leu His Lys 
145                 150                 155                 160 


Gly Glu Ala Gln Arg Cys Pro Arg Cys Gly Ala His Tyr Lys Leu Val 
                165                 170                 175     


Pro Gln Gln Leu Ala His 
            180         


<210>  8065
<211>  1551
<212>  DNA
<213>  Homosapiens

<400>  8065
acgcagtgat ctttaggagc ccacttctaa attcaaatca tttggggttc agtaagtctc     60

ttcacagacg gggacctaat agcttccatt agcagcctcc acgtttgctg aacacgacta    120

cggggccaga cccacaggaa ctccaatgtg gttcagccgc tcaactccag ggaccaaaaa    180

gactttccca cctcccagcg ttattaaagg caaccccgcc cccaagcctc agccactacg    240

cggtgcagaa agaggcagag ctgggcatgc gcaatttccg cccccgccac agtcttggga    300

gtgggcgggc tcgagggctg ggaggaagcc gaaagctgac cgagaggaga aagaagcccg    360

cccccggaag tccctcctgt ctctgcagct tgttcccgga agttttgctg ctagtcgcgg    420

acgcaatggc ttcaaggtta cttcgcggag ctggaacgct ggccgcgcag gccctgaggg    480

ctcgcggccc cagtggcgcg gccgcgatgc gctccatggc atctggaggt ggtgttccca    540

ctgatgaaga gcaggcgact gggttggaga gggagatcat gctggctgca aagaagggac    600

tggacccata caatgtactg gccccaaagg gagcttcagg caccagggaa gaccctaatt    660

tagtcccctc catctccaac aagagaatag taggctgcat ctgtgaagag gacaatacca    720

gcgtcgtctg gttttggctg cacaaaggcg aggcccagcg atgcccccgc tgtggagccc    780

attacaagct ggtgccccag cagctggcac actgagcacc tgcactaaat tactcaaaat    840

gtgctgtaaa gtttcttctt tccagtaaag actagccatt gcattggctc cttctcccat    900

agatggctgg tcttatttct tacccgtatt ctttggtagg catggaatat gcttattttg    960

ggaaaagctg tctgttaatg ctagcttgcc atccacttac tgaaagtgta taaccagtgt   1020

atagtgctta gattaataat aagaatagat cgacaacccg taatgcaatg aatgggacca   1080

cctggtatga gagaaagggg cgggctgagg agtcaggctg acaggactta aaatattggc   1140

tccatcattt ggctctatct ctgtggacat gttctctggg ggtcaagtac aactacaaaa   1200

aggtaagtac cttacaaggt gcttaatatg taaagagctg agtggatagt aggtcctcac   1260

agtatcctca tagagacagg gtggccttgt gaagagagtt ttggggattt tgaagtcttg   1320

agggacccag gtgcaaagta agaattcatg gggataccag cagcaaaatt cagaatatgg   1380

aacaatttca gaaatcactg accatgtttc ttcaaataaa ttgcaaggag tggggggaaa   1440

agctagggag aacatgtgga gaaacagata agggagatac cagtcagcag catgcacacc   1500

ttgtttagat cttgatttga aaacaattat aaaggaaaaa aaattgagaa g            1551


<210>  8066
<211>  182
<212>  PRT
<213>  Homosapiens

<400>  8066

Met Arg Asn Phe Arg Pro Arg His Ser Leu Gly Ser Gly Arg Ala Arg 
1               5                   10                  15      


Gly Leu Gly Gly Ser Arg Lys Leu Thr Glu Arg Arg Lys Lys Pro Ala 
            20                  25                  30          


Pro Gly Ser Pro Ser Cys Leu Cys Ser Leu Phe Pro Glu Val Leu Leu 
        35                  40                  45              


Leu Val Ala Asp Ala Met Ala Ser Arg Leu Leu Arg Gly Ala Gly Thr 
    50                  55                  60                  


Leu Ala Ala Gln Ala Leu Arg Ala Arg Gly Pro Ser Gly Ala Ala Ala 
65                  70                  75                  80  


Met Arg Ser Met Ala Ser Gly Gly Gly Val Pro Thr Asp Glu Glu Gln 
                85                  90                  95      


Ala Thr Gly Leu Glu Arg Glu Ile Met Leu Ala Ala Lys Lys Gly Leu 
            100                 105                 110         


Asp Pro Tyr Asn Val Leu Ala Pro Lys Gly Ala Ser Gly Thr Arg Glu 
        115                 120                 125             


Asp Pro Asn Leu Val Pro Ser Ile Ser Asn Lys Arg Ile Val Gly Cys 
    130                 135                 140                 


Ile Cys Glu Glu Asp Asn Thr Ser Val Val Trp Phe Trp Leu His Lys 
145                 150                 155                 160 


Gly Glu Ala Gln Arg Cys Pro Arg Cys Gly Ala His Tyr Lys Leu Val 
                165                 170                 175     


Pro Gln Gln Leu Ala His 
            180         


<210>  8067
<211>  642
<212>  DNA
<213>  Homosapiens

<400>  8067
gcggacgcaa tggcttcaag gttacttcgc ggagctggaa cgctggccgc gcaggccctc     60

ccagggtggt cccagggcgg caaagcggcg cggctcgtgc agcttctcga ggtcccagtg    120

gccgctttac ggtccccagt gcctcaggct ctgcaggcat ctccctgtaa ttctggaccg    180

ctgctcctgc cgctccccga actcactccg ctgcgaaagt atcctaaacg gaggtgccgg    240

gtgaccttgg gagggaccgg ggctgccacc gggatgggga ggggtccggc ctcccttcaa    300

acctgcgccc acctcaagca gagtgggttc tacatgcttt tagacaaatg tcgacaaatt    360

tgcctcggtg gttggagaaa gaaaagctca taggccgggc gcggtggctc acaactgtaa    420

tcccagcact ttgggaggcc gaggcggaca gatcccctga ggtcaggagc tcaagaccag    480

cctggccaac atggtaaaac cccgtttcta ctaaaaatac aaaaattagc cgggcgtggt    540

ggcgcgcgcc tgtagtccca gctactcggg aggctgaggc aggagaatcg cttaaacccg    600

ggaggcggag gttcccgtga gccaacatcg cgccattgca ct                       642


<210>  8068
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  8068

Met Ala Ser Arg Leu Leu Arg Gly Ala Gly Thr Leu Ala Ala Gln Ala 
1               5                   10                  15      


Leu Pro Gly Trp Ser Gln Gly Gly Lys Ala Ala Arg Leu Val Gln Leu 
            20                  25                  30          


Leu Glu Val Pro Val Ala Ala Leu Arg Ser Pro Val Pro Gln Ala Leu 
        35                  40                  45              


Gln Ala Ser Pro Cys Asn Ser Gly Pro Leu Leu Leu Pro Leu Pro Glu 
    50                  55                  60                  


Leu Thr Pro Leu Arg Lys Tyr Pro Lys Arg Arg Cys Arg Val Thr Leu 
65                  70                  75                  80  


Gly Gly Thr Gly Ala Ala Thr Gly Met Gly Arg Gly Pro Ala Ser Leu 
                85                  90                  95      


Gln Thr Cys Ala His Leu Lys Gln Ser Gly Phe Tyr Met Leu Leu Asp 
            100                 105                 110         


Lys Cys Arg Gln Ile Cys Leu Gly Gly Trp Arg Lys Lys Ser Ser 
        115                 120                 125         


<210>  8069
<211>  627
<212>  DNA
<213>  Homosapiens

<400>  8069
cagtggccgc tttacggtcc ccagtgcctc aggctctgca ggcatctccc tgtaattctg     60

gaccgctgct cctgccgctc cccgaactca ctccgctgcg aaaacaaatg tcgacaaatt    120

tgcctcggtg gttggagaaa gaaaagctca taggccgggc gcggtggctc acaactgtaa    180

tcccagcact ttgggaggcc gaggcggaca gatcccctga ggtcaggagc tcaagaccag    240

cctggccaac atggtggtgt tcccactgat gaagagcagg cgactgggtt ggagagggag    300

atcatgctgg ctgcaaagaa gggactggac ccatacaatg tactggcccc aaagggagct    360

tcaggcacca gggaagaccc taatttagtc ccctccatct ccaacaagag aatagtaggc    420

tgcatctgtg aagaggacaa taccagcgtc gtctggtttt ggctgcacaa aggcgaggcc    480

cagcgatgcc cccgctgtgg agcccattac aagctggtgc cccagcagct ggcacactga    540

gcacctgcac taaattactc aaaatgtgct gtaaagtttc ttctttccag taaagactag    600

ccattgcatt ggctccttct cccatag                                        627


<210>  8070
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  8070

Met Leu Ala Ala Lys Lys Gly Leu Asp Pro Tyr Asn Val Leu Ala Pro 
1               5                   10                  15      


Lys Gly Ala Ser Gly Thr Arg Glu Asp Pro Asn Leu Val Pro Ser Ile 
            20                  25                  30          


Ser Asn Lys Arg Ile Val Gly Cys Ile Cys Glu Glu Asp Asn Thr Ser 
        35                  40                  45              


Val Val Trp Phe Trp Leu His Lys Gly Glu Ala Gln Arg Cys Pro Arg 
    50                  55                  60                  


Cys Gly Ala His Tyr Lys Leu Val Pro Gln Gln Leu Ala His 
65                  70                  75              


<210>  8071
<211>  1276
<212>  DNA
<213>  Homosapiens

<400>  8071
cagtggccgc tttacggtcc ccagtgcctc aggctctgca ggcatctccc tgtaattctg     60

gaccgctgct cctgccgctc cccgaactca ctccgctgcg aaaacaaatg tcgacaaatt    120

tgcctcggtg gttggagaaa gaaaagctca taggccgggc gcggtggctc acaactgtaa    180

tcccagcact ttgggaggcc gaggcggaca gatcccctga ggtcaggagc tcaagaccag    240

cctggccaac atggtggtgt tcccactgat gaagagcagg cgactgggtt ggagagggag    300

atcatgctgg ctgcaaagaa gggactggac ccatacaatg tactggcccc aaagggagct    360

tcaggcacca gggaagaccc taatttagtc ccctccatct ccaacaagag aatagtaggc    420

tgcatctgtg aagaggacaa taccagcgtc gtctggtttt ggctgcacaa aggcgaggcc    480

cagcgatgcc cccgctgtgg agcccattac aagctggtgc cccagcagct ggcacactga    540

gcacctgcac taaattactc aaaatgtgct gtaaagtttc ttctttccag taaagactag    600

ccattgcatt ggctccttct cccatagatg gctggtctta tttcttaccc gtattctttg    660

gtaggcatgg aatatgctta ttttgggaaa agctgtctgt taatgctagc ttgccatcca    720

cttactgaaa gtgtataacc agtgtatagt gcttagatta ataataagaa tagatcgaca    780

acccgtaatg caatgaatgg gaccacctgg tatgagagaa aggggcgggc tgaggagtca    840

ggctgacagg acttaaaata ttggctccat catttggctc tatctctgtg gacatgttct    900

ctgggggtca agtacaacta caaaaaggta agtaccttac aaggtgctta atatgtaaag    960

agctgagtgg atagtaggtc ctcacagtat cctcatagag acagggtggc cttgtgaaga   1020

gagttttggg gattttgaag tcttgaggga cccaggtgca aagtaagaat tcatggggat   1080

accagcagca aaattcagaa tatggaacaa tttcagaaat cactgaccat gtttcttcaa   1140

ataaattgca aggagtgggg ggaaaagcta gggagaacat gtggagaaac agataaggga   1200

gataccagtc agcagcatgc acaccttgtt tagatcttga tttgaaaaca attataaagg   1260

aaaaaaaatt gagaag                                                   1276


<210>  8072
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  8072

Met Leu Ala Ala Lys Lys Gly Leu Asp Pro Tyr Asn Val Leu Ala Pro 
1               5                   10                  15      


Lys Gly Ala Ser Gly Thr Arg Glu Asp Pro Asn Leu Val Pro Ser Ile 
            20                  25                  30          


Ser Asn Lys Arg Ile Val Gly Cys Ile Cys Glu Glu Asp Asn Thr Ser 
        35                  40                  45              


Val Val Trp Phe Trp Leu His Lys Gly Glu Ala Gln Arg Cys Pro Arg 
    50                  55                  60                  


Cys Gly Ala His Tyr Lys Leu Val Pro Gln Gln Leu Ala His 
65                  70                  75              


<210>  8073
<211>  1002
<212>  DNA
<213>  Homosapiens

<400>  8073
caccgggatg gggaggggtc cggcctccct tcaaacctgc gcccacctca agcagagtgg     60

gttctacatg cttttagaca aatgtcgaca aatttgcctc ggtggttgga gaaagaaaag    120

ctcataggcc gggcgcggtg gctcacaact gtaatcccag cactttggga ggccgaggcg    180

gacagatccc ctgaggtcag gagctcaaga ccagcctggc caacatggta aaaccccgtt    240

tctactaaaa atacaaaaat tagccgggcg tggtggcgcg cgcctgtagt cccagctact    300

cgggaggctg aggcaggaga atcgcttaaa cccgggaggc ggaggttccc gtgagccaac    360

atcgcgccat tgcactccag cctgggcaac aagagcaaaa ctccgtctca aaaaagaaaa    420

aaaaagctcc cccgagtgct gccgcttgtg tggatgggta cttggtggtt cttaggggac    480

catggatatg agtagccttt aggagcttgt gagcccgcta aaacttatac agaagtttcg    540

gggcaccatt ttccttgatc atttctgttt gtagtttttc tatcagtcat ttcagtcagc    600

gtcataattc acgttatctt cctttaggtg gtgttcccac tgatgaagag caggcgactg    660

ggttggagag ggagatcatg ctggctgcaa agaagggact ggacccatac aatgtactgg    720

ccccaaaggg agcttcaggc accagggaag accctaattt agtcccctcc atctccaaca    780

agagaatagt aggctgcatc tgtgaagagg acaataccag cgtcgtctgg ttttggctgc    840

acaaaggcga ggcccagcga tgcccccgct gtggagccca ttacaagctg gtgccccagc    900

agctggcaca ctgagcacct gcactaaatt actcaaaatg tgctgtaaag tttcttcttt    960

ccagtaaaga ctagccattg cattggctcc ttctcccata ga                      1002


<210>  8074
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  8074

Met Leu Ala Ala Lys Lys Gly Leu Asp Pro Tyr Asn Val Leu Ala Pro 
1               5                   10                  15      


Lys Gly Ala Ser Gly Thr Arg Glu Asp Pro Asn Leu Val Pro Ser Ile 
            20                  25                  30          


Ser Asn Lys Arg Ile Val Gly Cys Ile Cys Glu Glu Asp Asn Thr Ser 
        35                  40                  45              


Val Val Trp Phe Trp Leu His Lys Gly Glu Ala Gln Arg Cys Pro Arg 
    50                  55                  60                  


Cys Gly Ala His Tyr Lys Leu Val Pro Gln Gln Leu Ala His 
65                  70                  75              


<210>  8075
<211>  972
<212>  DNA
<213>  Homosapiens

<400>  8075
gtcatttcag tcagcgtcat aattcacgtt atcttccttt aggtggtgtt cccactgatg     60

aagagcaggc gactgggttg gagagggaga tcatgctggc tgcaaagaag ggactggacc    120

catacaatgt actggcccca aagggagctt caggcaccag ggaagaccct aatttagtcc    180

cctccatctc caacaagaga atagtaggct gcatctgtaa gtacctcacc tctatttttt    240

atccacttgc ttaatatatc ctacaatagt gtgtaagctg cctcaaatct tcagtgtgtg    300

agtgcatgtt ggtaagtttg tctaagggtc ttgacactct caagcctcat tatgcctgat    360

agttcatcct tactggaaag aagcgcagca cagcggtaag actggctcac tgggagtgcg    420

gcatgaagga gtacccaccc agcaaatatt tattgttata ctgcttctat gccaggcatc    480

attttagaca ctagggatac ataccagaac ggaccctgct ttgcgttcta cataggcaag    540

ggaattgtta gaatttacag tgaccttgat acaaggtcag tttactcata ggtgaactca    600

gagcctcaat ttcttcatct gaagaatggg aggagggctt gaactgatct cttaagatat    660

caaccatagt cttacttgtg tatcagagat gtctgaggaa aagaaattca tgttgaaagt    720

ctccctttct aggttggatg accataaacc accttttttc ccttttaggt gaagaggaca    780

ataccagcgt cgtctggttt tggctgcaca aaggcgaggc ccagcgatgc ccccgctgtg    840

gagcccatta caagctggtg ccccagcagc tggcacactg agcacctgca ctaaattact    900

caaaatgtgc tgtaaagttt cttctttcca gtaaagacta gccattgcat tggctccttc    960

tcccatagat gg                                                        972


<210>  8076
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  8076

Met Leu Ala Ala Lys Lys Gly Leu Asp Pro Tyr Asn Val Leu Ala Pro 
1               5                   10                  15      


Lys Gly Ala Ser Gly Thr Arg Glu Asp Pro Asn Leu Val Pro Ser Ile 
            20                  25                  30          


Ser Asn Lys Arg Ile Val Gly Cys Ile Cys Lys Tyr Leu Thr Ser Ile 
        35                  40                  45              


Phe Tyr Pro Leu Ala 
    50              


<210>  8077
<211>  307
<212>  DNA
<213>  Homosapiens

<400>  8077
cgctggacac ttttaagaag atgtgggtgt ccaaaaagga gtatgaagag gatggctccc     60

gtgctattca tcgcaaaact ttctagtgcc caaggagggc ggggcatgtt gggagagggg    120

gaggggtggg ggacattttc ttacctcacc caagaaagag gtcgtcactt ttgctgtggc    180

cagggcccca cctccctctc tcagatatgt acaataattt aacacggttg cctgaaaaaa    240

acttttgtaa atcattatag taataattat ggacaaggcc cagtgtgtgg ctctgttttc    300

ttgtggc                                                              307


<210>  8078
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  8078

Met Lys Arg Met Ala Pro Val Leu Phe Ile Ala Lys Leu Ser Ser Ala 
1               5                   10                  15      


Gln Gly Gly Arg Gly Met Leu Gly Glu Gly Glu Gly Trp Gly Thr Phe 
            20                  25                  30          


Ser Tyr Leu Thr Gln Glu Arg Gly Arg His Phe Cys Cys Gly Gln Gly 
        35                  40                  45              


Pro Thr Ser Leu Ser Gln Ile Cys Thr Ile Ile 
    50                  55                  


<210>  8079
<211>  485
<212>  DNA
<213>  Homosapiens

<400>  8079
cgctggacac ttttaagaag atgtgggtgt ccaaaaagga gtatgaagag gatggctccc     60

gtgctattca tcgcaaaact ttctagtgcc caaggagggc ggggcatgtt gggagagggg    120

gagggagggg agacagaagc cagggcagag gatgcacggt ggctagagcc gctgcactat    180

ccttttcaga gcacttcatc cacttgctcc tccctctacc ctcggcaccc tgggtgggaa    240

agggttgatg ctcatcattt attgagggga agccacttaa taaggagtca gacctaaaag    300

ggggtggggg acattttctt acctcaccca agaaagaggt cgtcactttt gctgtggcca    360

gggccccacc tccctctctc agatatgtac aataatttaa cacggttgcc tgaaaaaaac    420

ttttgtaaat cattatagta ataattatgg acaaggccca gtgtgtggct ctgttttctt    480

gtggc                                                                485


<210>  8080
<211>  84
<212>  PRT
<213>  Homosapiens

<400>  8080

Met Lys Arg Met Ala Pro Val Leu Phe Ile Ala Lys Leu Ser Ser Ala 
1               5                   10                  15      


Gln Gly Gly Arg Gly Met Leu Gly Glu Gly Glu Gly Gly Glu Thr Glu 
            20                  25                  30          


Ala Arg Ala Glu Asp Ala Arg Trp Leu Glu Pro Leu His Tyr Pro Phe 
        35                  40                  45              


Gln Ser Thr Ser Ser Thr Cys Ser Ser Leu Tyr Pro Arg His Pro Gly 
    50                  55                  60                  


Trp Glu Arg Val Asp Ala His His Leu Leu Arg Gly Ser His Leu Ile 
65                  70                  75                  80  


Arg Ser Gln Thr 
                


<210>  8081
<211>  371
<212>  DNA
<213>  Homosapiens

<400>  8081
cgattccggg cccccgagct gctgttccag ccggaccttg tcggggatga gagtgagggg     60

ctccatgagg tggtggcctt cgccatacac aagtccgaca tggacctgcg ccggacgctg    120

ttcgccaaca tcgtggctca tcatttattg aggggaagcc acttaataag gagtcagacc    180

taaaaggggg tgggggacat tttcttacct cacccaagaa agaggtcgtc acttttgctg    240

tggccagggc cccacctccc tctctcagat atgtacaata atttaacacg gttgcctgaa    300

aaaaactttt gtaaatcatt atagtaataa ttatggacaa ggcccagtgt gtggctctgt    360

tttcttgtgg c                                                         371


<210>  8082
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  8082

Met Arg Val Arg Gly Ser Met Arg Trp Trp Pro Ser Pro Tyr Thr Ser 
1               5                   10                  15      


Pro Thr Trp Thr Cys Ala Gly Arg Cys Ser Pro Thr Ser Trp Leu Ile 
            20                  25                  30          


Ile Tyr 
        


<210>  8083
<211>  458
<212>  DNA
<213>  Homosapiens

<400>  8083
agcactgaaa gaacaagaca agcgttctag ggttcccctt tgtcttggga gtctctcgtt     60

ttggtcttgt tgagccacaa gggggtgcag cccagggtca ggcccttcag agccagggca    120

gaggatgcac ggtggctaga gccgctgcac tatccttttc agagcacttc atccacttgc    180

tcctccctct accctcggca ccctgggtgg gaaagggttg atgctcatca tttattgagg    240

ggaagccact taataaggag tcagacctaa aagggggtgg gggacatttt cttacctcac    300

ccaagaaaga ggtcgtcact tttgctgtgg ccagggcccc acctccctct ctcagatatg    360

tacaataatt taacacggtt gcctgaaaaa aacttttgta aatcattata gtaataatta    420

tggacaaggc ccagtgtgtg gctctgtttt cttgtggc                            458


<210>  8084
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  8084

Gly Ser Pro Leu Ser Trp Glu Ser Leu Val Leu Val Leu Leu Ser His 
1               5                   10                  15      


Lys Gly Val Gln Pro Arg Val Arg Pro Phe Arg Ala Arg Ala Glu Asp 
            20                  25                  30          


Ala Arg Trp Leu Glu Pro Leu His Tyr Pro Phe Gln Ser Thr Ser Ser 
        35                  40                  45              


Thr Cys Ser Ser Leu Tyr Pro Arg His Pro Gly Trp Glu Arg Val Asp 
    50                  55                  60                  


Ala His His Leu Leu Arg Gly Ser His Leu Ile Arg Ser Gln Thr 
65                  70                  75                  


<210>  8085
<211>  2267
<212>  DNA
<213>  Homosapiens

<400>  8085
cccgggcacc tgctgtcaat cgggccaggt gggagcgatg attggccgcc gggcccgccc     60

tccagaaagc cccgcggggc tcgcgtaggc tgcaggctcg gggagggagg gcagcggcgc    120

cgcgtcggga gccgccgccg tcccggtcct cccgcccgcc cgcccatccg gtgcctcctg    180

cagcccgcct gctgggcagg gccggcgcgg cccggccatg gagtcctacg acatcatcgc    240

caaccagcct gtggtcatcg acaacggttc gggggtgatt aaagctggct ttgcaggaga    300

ccagattccc aaatactgtt tcccaaacta tgtcgggcgg ccgaagcaca tgcgggtgat    360

ggctggagcc ctggaggggg acctcttcat cggaccaaaa gcagaggagc accgggggct    420

gctgaccatc cgctacccca tggagcacgg cgtggtgcga gactggaacg acatggaacg    480

catctggcag tacgtctact ccaaggatca gctgcagacc ttctcggagg agcatcctgt    540

gctcctcacg gaggccccgc tcaacccgag taagaaccgg gagaaggcgg cagaggtgtt    600

ctttgagacc ttcaacgtgc cggccctgtt catctccatg caggctgtgc tcagtctgta    660

cgcaacagga cgcacgacag gagtggttct agactcaggg gacggggtca ctcatgctgt    720

gcccatctat gagggctttg ccatgcctca ctccatcatg cgggtggaca ttgccggccg    780

cgacgtctcc cgctacctcc gactcctgct gcgcaaggaa ggggttgact tccatacctc    840

ggctgagttt gaggttgtcc ggacaatcaa agagcgagcg tgctacctgt ccatcaaccc    900

acagaaggat gaggctctgg agacggagaa ggtgcagtac acgttgccag acggcagcac    960

gcttgatgtg gggcctgcac gattccgggc ccccgagctg ctgttccagc cggaccttgt   1020

cggggatgag agtgaggggc tccatgaggt ggtggccttc gccatacaca agtccgacat   1080

ggacctgcgc cggacgctgt tcgccaacat cgtgctctca ggtggctcaa cgcttttcaa   1140

aggcttcgga gaccgattac tcagtgaagt gaagaagctt gccccaaagg atatcaaaat   1200

caagatctca gccccgcagg aacggctgta ctccacatgg attggcggct ccatcctggc   1260

ctcgctggac acttttaaga agatgtgggt gtccaaaaag gagtatgaag aggatggctc   1320

ccgtgctatt catcgcaaaa ctttctagtg cccaaggagg gcggggcatg ttgggagagg   1380

gggagggagg ggagacagag cctttaaccc tttttggtct tggctcgtat actaggctta   1440

gggtcccctg catgccctga acccctgggt gggtggcaca gcagtgcccc cctgcagcct   1500

tcccctctac acaggacatg cacacacaag taacattgag ctgcatggac aggagccttg   1560

agctggcgtg tgggaattga gcgccatgtc aggctgttgt gggtatcccc ctggcagggc   1620

cagctaggcc tgtggttccc tgctccgact ctcagggctg cctccctgag ctccagggcc   1680

agaatgcctg gatgcctggg tagccagttt ggggagtggg ctgcaagggg cagccagcag   1740

ctcccactgg tgtgtcactg catccattgc cacctcctgt tcgtgacctg acagggtgac   1800

acagcccctt tcacactctg tcctcctatc ttcctgggta gatgccctgg tgtagggctg   1860

agtactgaat ggtcttccat ccccagcaag ggggtgcagc ccagggtcag gcccttcaga   1920

gccagggcag aggatgcacg gtggctagag ccgctgcact atccttttca gagcacttca   1980

tccacttgct cctccctcta ccctcggcac cctgggtggg aaagggttga tgctcatcat   2040

ttattgaggg gaagccactt aataaggagt cagacctaaa agggggtggg ggacattttc   2100

ttacctcacc caagaaagag gtcgtcactt ttgctgtggc cagggcccca cctccctctc   2160

tcagatatgt acaataattt aacacggttg cctgaaaaaa acttttgtaa atcattatag   2220

taataattat ggacaaggcc cagtgtgtgg ctctgttttc ttgtggc                 2267


<210>  8086
<211>  376
<212>  PRT
<213>  Homosapiens

<400>  8086

Met Glu Ser Tyr Asp Ile Ile Ala Asn Gln Pro Val Val Ile Asp Asn 
1               5                   10                  15      


Gly Ser Gly Val Ile Lys Ala Gly Phe Ala Gly Asp Gln Ile Pro Lys 
            20                  25                  30          


Tyr Cys Phe Pro Asn Tyr Val Gly Arg Pro Lys His Met Arg Val Met 
        35                  40                  45              


Ala Gly Ala Leu Glu Gly Asp Leu Phe Ile Gly Pro Lys Ala Glu Glu 
    50                  55                  60                  


His Arg Gly Leu Leu Thr Ile Arg Tyr Pro Met Glu His Gly Val Val 
65                  70                  75                  80  


Arg Asp Trp Asn Asp Met Glu Arg Ile Trp Gln Tyr Val Tyr Ser Lys 
                85                  90                  95      


Asp Gln Leu Gln Thr Phe Ser Glu Glu His Pro Val Leu Leu Thr Glu 
            100                 105                 110         


Ala Pro Leu Asn Pro Ser Lys Asn Arg Glu Lys Ala Ala Glu Val Phe 
        115                 120                 125             


Phe Glu Thr Phe Asn Val Pro Ala Leu Phe Ile Ser Met Gln Ala Val 
    130                 135                 140                 


Leu Ser Leu Tyr Ala Thr Gly Arg Thr Thr Gly Val Val Leu Asp Ser 
145                 150                 155                 160 


Gly Asp Gly Val Thr His Ala Val Pro Ile Tyr Glu Gly Phe Ala Met 
                165                 170                 175     


Pro His Ser Ile Met Arg Val Asp Ile Ala Gly Arg Asp Val Ser Arg 
            180                 185                 190         


Tyr Leu Arg Leu Leu Leu Arg Lys Glu Gly Val Asp Phe His Thr Ser 
        195                 200                 205             


Ala Glu Phe Glu Val Val Arg Thr Ile Lys Glu Arg Ala Cys Tyr Leu 
    210                 215                 220                 


Ser Ile Asn Pro Gln Lys Asp Glu Ala Leu Glu Thr Glu Lys Val Gln 
225                 230                 235                 240 


Tyr Thr Leu Pro Asp Gly Ser Thr Leu Asp Val Gly Pro Ala Arg Phe 
                245                 250                 255     


Arg Ala Pro Glu Leu Leu Phe Gln Pro Asp Leu Val Gly Asp Glu Ser 
            260                 265                 270         


Glu Gly Leu His Glu Val Val Ala Phe Ala Ile His Lys Ser Asp Met 
        275                 280                 285             


Asp Leu Arg Arg Thr Leu Phe Ala Asn Ile Val Leu Ser Gly Gly Ser 
    290                 295                 300                 


Thr Leu Phe Lys Gly Phe Gly Asp Arg Leu Leu Ser Glu Val Lys Lys 
305                 310                 315                 320 


Leu Ala Pro Lys Asp Ile Lys Ile Lys Ile Ser Ala Pro Gln Glu Arg 
                325                 330                 335     


Leu Tyr Ser Thr Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Asp Thr 
            340                 345                 350         


Phe Lys Lys Met Trp Val Ser Lys Lys Glu Tyr Glu Glu Asp Gly Ser 
        355                 360                 365             


Arg Ala Ile His Arg Lys Thr Phe 
    370                 375     


<210>  8087
<211>  1473
<212>  DNA
<213>  Homosapiens

<400>  8087
agaagactgg cttctccatg atggtttatg gactaaggca aagatgagca gagccatggc     60

cctcttcttt gttctctgct ggatccaaga gtcgggggtc tccctatgtt tcccaggctg    120

gcctcgaact cctgacctca agtgatcctc ccacctcagc ctccccgagt gctgggatta    180

aagacgtgag ccacggcacc tggcctgaat tttcctcaaa ttcaaaaaat cctgatgaag    240

gtttggctaa aatctttgat gaaattgtgc tccaagtgtt ttccaaggtt ccgtatgacc    300

catcatttga tgaaacaaga acagcagtca gatccattac aaagagagac acacaaaaaa    360

actatgtgaa aatgagctta gcccctggtg ttgtgttgga acttcagatg cttgcagaca    420

cttcatgaat gctctgtgac actcagaata ggctattccc aacagaagag cttgaacaat    480

gctgcatttg catcaggttc aaatgagcga gaggaacatt tggctaaaat atttgatgaa    540

attctactgc aggtgtttcc aaagtttccg tatgacccat catttaacga agcaacagca    600

gtcagatcca ttacaaagac agacatgaga aaaggaacca gcattgcttg gaattctcct    660

aaaccagaat atttccttgg cagtgtggac aaaattcctg ataaagatca cctttcagag    720

gagaagaatt ttaaagaatc ctgtctgttc gacagggatt taagagagca gttaactact    780

atagataaag aaacacttca aggagcagct aaaccagatg ctcactttag gactatgccc    840

tgcgggcagc ttctgcactt cctgcagagg aacaccatca tcgccgccgt ctcaggggtg    900

gccatcctca tggccatcgt gctgttgctg cttgggttgg cctcatacat caggaagaaa    960

cagccatcgg acatgtattc ctgaccacag aaggaagagc agctccccac agcccttcag   1020

tcctgcctga cactgcactg aatgctcagc ttgcccctag agcaatgggg tggagatctc   1080

ctctggcaaa cacgacatat aatattttta taatggatgg aaagacatgg tggcacaatt   1140

ctgaagaaaa aaatttcaca aaacttgcaa aaaaacagaa acagttgaag agcagctcct   1200

gtgtctaagc caggtcgtgg ggccgtcaaa ccaggacttg aaaccacaat gcgaggacat   1260

tctccatctg cgcaccacag ggaggcaatt ccatttctgc ccgggaggtg tattctacaa   1320

aaacgtctgc ttcccatccc aatttgaatg gaccaagaaa aactgcttta ccataggaca   1380

cttgtggcaa tatggcaccg atggctggcg tcggtgaacc cgacagacta tggatttatc   1440

atttaataaa gcattgattc attttttcag tca                                1473


<210>  8088
<211>  119
<212>  PRT
<213>  Homosapiens

<400>  8088

Met Arg Lys Gly Thr Ser Ile Ala Trp Asn Ser Pro Lys Pro Glu Tyr 
1               5                   10                  15      


Phe Leu Gly Ser Val Asp Lys Ile Pro Asp Lys Asp His Leu Ser Glu 
            20                  25                  30          


Glu Lys Asn Phe Lys Glu Ser Cys Leu Phe Asp Arg Asp Leu Arg Glu 
        35                  40                  45              


Gln Leu Thr Thr Ile Asp Lys Glu Thr Leu Gln Gly Ala Ala Lys Pro 
    50                  55                  60                  


Asp Ala His Phe Arg Thr Met Pro Cys Gly Gln Leu Leu His Phe Leu 
65                  70                  75                  80  


Gln Arg Asn Thr Ile Ile Ala Ala Val Ser Gly Val Ala Ile Leu Met 
                85                  90                  95      


Ala Ile Val Leu Leu Leu Leu Gly Leu Ala Ser Tyr Ile Arg Lys Lys 
            100                 105                 110         


Gln Pro Ser Asp Met Tyr Ser 
        115                 


<210>  8089
<211>  1366
<212>  DNA
<213>  Homosapiens

<400>  8089
agaagactgg cttctccatg atggtttatg gactaaggca aagatgagca gagccatggc     60

cctcttcttt gttctctgct ggatccaaga gtcgggggtc tccctatgtt tcccaggctg    120

gcctcgaact cctgacctca agtgatcctc ccacctcagc ctccccgagt gctgggatta    180

aagacgtgag ccacggcacc tggcctgaat tttcctcaaa ttcaaaaaat cctgatgaag    240

gtttggctaa aatctttgat gaaattgtgc tccaagtgtt ttccaaggtt ccgtatgacc    300

catcatttga tgaaacaaga acagcagtca gatccattac aaagagagac acacaaaaaa    360

actatgtgaa aatgagctta gcccctggtg ttgtgttgga acttcagatg cttgcagaca    420

cttcatgaat gctctgtgac actcagaata ggctattccc aacagaagag cttgaacaat    480

gctgcatttg catcaggttc aaatgagcga gaggaacatt tggctaaaat atttgatgaa    540

attctactgc aggtgtttcc aaagtttccg tatgacccat catttaacga agcaacagca    600

gtcagatcca ttacaaagac agacatgaga aaaggaacca gcattgcttg gaattctcct    660

aaaccagaat atttccttgg cagtgtggac aaaattcctg ataaagatca cctttcagag    720

gagaagaatt ttaaagaatc ctgtctgttc gacagggatt taagagagca gttaactact    780

atagataaag aaacacttca aggagcagct aaaccagatg ctcactttag gactatgccc    840

tgcgggcagc ttctgcactt cctgcagagg aacaccatca tcgccgccgt ctcaggggtg    900

gccatcctca tggccatcgt gctgttgctg cttgggttgg cctcatacat caggaagaaa    960

cagccatcat ctcctctggc aaacacgaca tataatattt ttataatgga tggaaagaca   1020

tggtggcaca attctgaaga aaaaaatttc acaaaacttg caaaaaaaca gaaacagttg   1080

aagagcagct cctgtgtcta agccaggtcg tggggccgtc aaaccaggac ttgaaaccac   1140

aatgcgagga cattctccat ctgcgcacca cagggaggca attccatttc tgcccgggag   1200

gtgtattcta caaaaacgtc tgcttcccat cccaatttga atggaccaag aaaaactgct   1260

ttaccatagg acacttgtgg caatatggca ccgatggctg gcgtcggtga acccgacaga   1320

ctatggattt atcatttaat aaagcattga ttcatttttt cagtca                  1366


<210>  8090
<211>  158
<212>  PRT
<213>  Homosapiens

<400>  8090

Met Arg Lys Gly Thr Ser Ile Ala Trp Asn Ser Pro Lys Pro Glu Tyr 
1               5                   10                  15      


Phe Leu Gly Ser Val Asp Lys Ile Pro Asp Lys Asp His Leu Ser Glu 
            20                  25                  30          


Glu Lys Asn Phe Lys Glu Ser Cys Leu Phe Asp Arg Asp Leu Arg Glu 
        35                  40                  45              


Gln Leu Thr Thr Ile Asp Lys Glu Thr Leu Gln Gly Ala Ala Lys Pro 
    50                  55                  60                  


Asp Ala His Phe Arg Thr Met Pro Cys Gly Gln Leu Leu His Phe Leu 
65                  70                  75                  80  


Gln Arg Asn Thr Ile Ile Ala Ala Val Ser Gly Val Ala Ile Leu Met 
                85                  90                  95      


Ala Ile Val Leu Leu Leu Leu Gly Leu Ala Ser Tyr Ile Arg Lys Lys 
            100                 105                 110         


Gln Pro Ser Ser Pro Leu Ala Asn Thr Thr Tyr Asn Ile Phe Ile Met 
        115                 120                 125             


Asp Gly Lys Thr Trp Trp His Asn Ser Glu Glu Lys Asn Phe Thr Lys 
    130                 135                 140                 


Leu Ala Lys Lys Gln Lys Gln Leu Lys Ser Ser Ser Cys Val 
145                 150                 155             


<210>  8091
<211>  1192
<212>  DNA
<213>  Homosapiens

<400>  8091
gactaaggca aagatgagca gagccatggc cctcttcttt gttctctgct ggatccaagt     60

agagatggga tttcatcatg ttggccaggc tggtcatgaa ctcctgacct caatggatcc    120

tcctgcctca gcttcctgag tagctgggac cacaggtgca caccaccacg cccagatgaa    180

attgtgctcc aagtgttttc caaggttccg tatgacccat catttgatga aacaagaaca    240

gcagtcagat ccattacaaa gagagacaca caaaaaagct attcccaaca gaagagcttg    300

aacaatgctg catttgcatc aggttcaaat gagcgagagg aacatttggc taaaatattt    360

gatgaaattc tactgcaggt gtttccaaag tttccgtatg acccatcatt taacgaagca    420

acagcagtca gatccattac aaagacagac atgagaaaag gaaccagcat tgcttggaat    480

tctcctaaac cagaatattt ccttggcagt gtggacaaaa ttcctgataa agatcacctt    540

tcagaggaga agaattttaa agaatcctgt ctgttcgaca gggatttaag agagcagtta    600

actactatag ataaagaaac acttcaagga gcagctaaac cagatgctca ctttaggact    660

atgccctgcg ggcagcttct gcacttcctg cagaggaaca ccatcatcgc cgccgtctca    720

ggggtggcca tcctcatggc catcgtgctg ttgctgcttg ggttggcctc atacatcagg    780

aagaaacagc catcatctcc tctggcaaac acgacatata atatttttat aatggatgga    840

aagacatggt ggcacaattc tgaagaaaaa aatttcacaa aacttgcaaa aaaacagaaa    900

cagttgaaga gcagctcctg tgtctaagcc aggtcgtggg gccgtcaaac caggacttga    960

aaccacaatg cgaggacatt ctccatctgc gcaccacagg gaggcaattc catttctgcc   1020

cgggaggtgt attctacaaa aacgtctgct tcccatccca atttgaatgg accaagaaaa   1080

actgctttac cataggacac ttgtggcaat atggcaccga tggctggcgt cggtgaaccc   1140

gacagactat ggatttatca tttaataaag cattgattca ttttttcagt ca           1192


<210>  8092
<211>  158
<212>  PRT
<213>  Homosapiens

<400>  8092

Met Arg Lys Gly Thr Ser Ile Ala Trp Asn Ser Pro Lys Pro Glu Tyr 
1               5                   10                  15      


Phe Leu Gly Ser Val Asp Lys Ile Pro Asp Lys Asp His Leu Ser Glu 
            20                  25                  30          


Glu Lys Asn Phe Lys Glu Ser Cys Leu Phe Asp Arg Asp Leu Arg Glu 
        35                  40                  45              


Gln Leu Thr Thr Ile Asp Lys Glu Thr Leu Gln Gly Ala Ala Lys Pro 
    50                  55                  60                  


Asp Ala His Phe Arg Thr Met Pro Cys Gly Gln Leu Leu His Phe Leu 
65                  70                  75                  80  


Gln Arg Asn Thr Ile Ile Ala Ala Val Ser Gly Val Ala Ile Leu Met 
                85                  90                  95      


Ala Ile Val Leu Leu Leu Leu Gly Leu Ala Ser Tyr Ile Arg Lys Lys 
            100                 105                 110         


Gln Pro Ser Ser Pro Leu Ala Asn Thr Thr Tyr Asn Ile Phe Ile Met 
        115                 120                 125             


Asp Gly Lys Thr Trp Trp His Asn Ser Glu Glu Lys Asn Phe Thr Lys 
    130                 135                 140                 


Leu Ala Lys Lys Gln Lys Gln Leu Lys Ser Ser Ser Cys Val 
145                 150                 155             


<210>  8093
<211>  961
<212>  DNA
<213>  Homosapiens

<400>  8093
aaatattgct gatattaaca tgcctttgtt tgcttcactg gagatgaaat tgtgctccaa     60

gtgttttcca aggttccgta tgacccatca tttgatgaaa caagaacagc agtcagatcc    120

attacaaaga gagacacaca aaaaagctat tcccaacaga agagcttgaa caatgctgca    180

tttgcatcag gttcaaatga gcgagaggaa catttggcta aaatatttgg aaccagcatt    240

gcttggaatt ctcctaaacc agaatatttc cttggcagtg tggacaaaat tcctgataaa    300

gatcaccttt cagaggagaa gaattttaaa gaatcctgtc tgttcgacag ggatttaaga    360

gagcagttaa ctactataga taaagaaaca cttcaaggag cagctaaacc agatgctcac    420

tttaggacta tgccctgcgg gcagcttctg cacttcctgc agaggaacac catcatcgcc    480

gccgtctcag gggtggccat cctcatggcc atcgtgctgt tgctgcttgg gttggcctca    540

tacatcagga agaaacagcc atcatctcct ctggcaaaca cgacatataa tatttttata    600

atggatggaa agacatggtg gcacaattct gaagaaaaaa atttcacaaa acttgcaaaa    660

aaacagaaac agttgaagag cagctcctgt gtctaagcca ggtcgtgggg ccgtcaaacc    720

aggacttgaa accacaatgc gaggacattc tccatctgcg caccacaggg aggcaattcc    780

atttctgccc gggaggtgta ttctacaaaa acgtctgctt cccatcccaa tttgaatgga    840

ccaagaaaaa ctgctttacc ataggacact tgtggcaata tggcaccgat ggctggcgtc    900

ggtgaacccg acagactatg gatttatcat ttaataaagc attgattcat tttttcagtc    960

a                                                                    961


<210>  8094
<211>  88
<212>  PRT
<213>  Homosapiens

<400>  8094

Met Pro Cys Gly Gln Leu Leu His Phe Leu Gln Arg Asn Thr Ile Ile 
1               5                   10                  15      


Ala Ala Val Ser Gly Val Ala Ile Leu Met Ala Ile Val Leu Leu Leu 
            20                  25                  30          


Leu Gly Leu Ala Ser Tyr Ile Arg Lys Lys Gln Pro Ser Ser Pro Leu 
        35                  40                  45              


Ala Asn Thr Thr Tyr Asn Ile Phe Ile Met Asp Gly Lys Thr Trp Trp 
    50                  55                  60                  


His Asn Ser Glu Glu Lys Asn Phe Thr Lys Leu Ala Lys Lys Gln Lys 
65                  70                  75                  80  


Gln Leu Lys Ser Ser Ser Cys Val 
                85              


<210>  8095
<211>  2431
<212>  DNA
<213>  Homosapiens

<400>  8095
gaaataggtt agtttcagac aagcctgctt gccggagctc agcagacacc aggccttccg     60

ggcaggcctg gcccaccgtg ggcctcagag ctgctgctgg ggcattcaga accggctctc    120

cattggcatt gggaccagag accccgcaag tggcctgttt gcctggacat ccacctgtac    180

gtccccaggt ttcgggaggc ccaggggcga tgccagaccc cgcggcgcac ctgcccttct    240

tctacggcag catctcgcgt gccgaggccg aggagcacct gaagctggcg ggcatggcgg    300

acgggctctt cctgctgcgc cagtgcctgc gctcgctggg cggctatgtg ctgtcgctcg    360

tgcacgatgt gcgcttccac cactttccca tcgagcgcca gctcaacggc acctacgcca    420

ttgccggcgg caaagcgcac tgtggaccgg cagagctctg cgagttctac tcgcgcgacc    480

ccgacgggct gccctgcaac ctgcgcaagc cgtgcaaccg gccgtcgggc ctcgagccgc    540

agccgggggt cttcgactgc ctgcgagacg ccatggtgcg tgactacgtg cgccagacgt    600

ggaagctgga gggcgaggcc ctggagcagg ccatcatcag ccaggccccg caggtggaga    660

agctcattgc tacgacggcc cacgagcgga tgccctggta ccacagcagc ctgacgcgtg    720

aggaggccga gcgcaaactt tactctgggg cgcagaccga cggcaagttc ctgctgaggc    780

cgcggaagga gcagggcaca tacgccctgt ccctcatcta tgggaagacg gtgtaccact    840

acctcatcag ccaagacaag gcgggcaagt actgcattcc cgagggcacc aagtttgaca    900

cgctctggca gctggtggag tatctgaagc tgaaggcgga cgggctcatc tactgcctga    960

aggaggcctg ccccaacagc agtgccagca acgcctcagg ggctgctgct cccacactcc   1020

cagcccaccc atccacgttg actcatcctc agagacgaat cgacaccctc aactcagatg   1080

gatacacccc tgagccagca cgcataacgt ccccagacaa accgcggccg atgcccatgg   1140

acacgagcgt gtatgagagc ccctacagcg acccagagga gctcaaggac aagaagctct   1200

tcctgaagcg cgataacctc ctcatagctg acattgaact tggctgcggc aactttggct   1260

cagtgcgcca gggcgtgtac cgcatgcgca agaagcagat cgacgtggcc atcaaggtgc   1320

tgaagcaggg cacggagaag gcagacacgg aagagatgat gcgcgaggcg cagatcatgc   1380

accagctgga caacccctac atcgtgcggc tcattggcgt ctgccaggcc gaggccctca   1440

tgctggtcat ggagatggct gggggcgggc cgctgcacaa gttcctggtc ggcaagaggg   1500

aggagatccc tgtgagcaat gtggccgagc tgctgcacca ggtgtccatg gggatgaagt   1560

acctggagga gaagaacttt gtgcaccgtg acctggcggc ccgcaacgtc ctgctggtta   1620

accggcacta cgccaagatc agcgactttg gcctctccaa agcactgggt gccgacgaca   1680

gctactacac tgcccgctca gcagggaagt ggccgctcaa gtggtacgca cccgaatgca   1740

tcaacttccg caagttctcc agccgcagcg atgtctggag ctatggggtc accatgtggg   1800

aggccttgtc ctacggccag aagccctaca agaagatgaa agggccggag gtcatggcct   1860

tcatcgagca gggcaagcgg atggagtgcc caccagagtg tccacccgaa ctgtacgcac   1920

tcatgagtga ctgctggatc tacaagtggg aggatcgccc cgacttcctg accgtggagc   1980

agcgcatgcg agcctgttac tacagcctgg ccagcaaggt ggaagggccc ccaggcagca   2040

cacagaaggc tgaggctgcc tgtgcctgag ctcccgctgc ccaggggagc cctccacgcc   2100

ggctcttccc caccctcagc cccaccccag gtcctgcagt ctggctgagc cctgcttggt   2160

tgtctccaca cacagctggg ctgtggtagg gggtgtctca ggccacaccg gccttgcatt   2220

gcctgcctgg ccccctgtcc tctctggctg gggagcaggg aggtccggga gggtgcggct   2280

gtgcagcctg tcctgggctg gtggctcccg gagggccctg agctgagggc attgcttaca   2340

cggatgcctt cccctgggcc ctgacattgg agcctgggca tcctcaggtg gtcaggcgta   2400

gatcaccaga ataaacccag cttccctctt g                                  2431


<210>  8096
<211>  619
<212>  PRT
<213>  Homosapiens

<400>  8096

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  8097
<211>  3097
<212>  DNA
<213>  Homosapiens

<400>  8097
gaaataggtt agtttcagac aagcctgctt gccggagctc agcagacacc aggccttccg     60

ggcaggcctg gcccaccgtg ggcctcagag ctgctgctgg ggcattcaga accggctctc    120

cattggcatt gggaccagag accccgcaag tggcctgttt gcctggacat ccacctgtac    180

gtccccaggt ttcgggaggc ccaggggcga tgccagaccc cgcggcgcac ctgcccttct    240

tctacggcag catctcgcgt gccgaggccg aggagcacct gaagctggcg ggcatggcgg    300

acgggctctt cctgctgcgc cagtgcctgc gctcgctggg cggctatgtg ctgtcgctcg    360

tgcacgatgt gcgcttccac cactttccca tcgagcgcca gctcaacggc acctacgcca    420

ttgccggcgg caaagcgcac tgtggaccgg cagagctctg cgagttctac tcgcgcgacc    480

ccgacgggct gccctgcaac ctgcgcaagc cgtgcaaccg gccgtcgggc ctcgagccgc    540

agccgggggt cttcgactgc ctgcgagacg ccatggtgcg tgactacgtg cgccagacgt    600

ggaagctgga gggcgaggcc ctggagcagg ccatcatcag ccaggccccg caggtggaga    660

agctcattgc tacgacggcc cacgagcgga tgccctggta ccacagcagc ctgacgcgtg    720

aggaggccga gcgcaaactt tactctgggg cgcagaccga cggcaagttc ctgctgaggc    780

cgcggaagga gcagggcaca tacgccctgt ccctcatcta tgggaagacg gtgtaccact    840

acctcatcag ccaagacaag gcgggcaagt actgcattcc cgagggcacc aagtttgaca    900

cgctctggca gctggtggag tatctgaagc tgaaggcgga cgggctcatc tactgcctga    960

aggaggcctg ccccaacagc agtgccagca acgcctcagg ggctgctgct cccacactcc   1020

cagcccaccc atccacgttg actcatcctc agagacgaat cgacaccctc aactcagatg   1080

gatacacccc tgagccagca cgcataacgt ccccagacaa accgcggccg atgcccatgg   1140

acacgagcgt gtatgagagc ccctacagcg acccagagga gctcaaggac aagaagctct   1200

tcctgaagcg cgataacctc ctcatagctg acattgaact tggctgcggc aactttggct   1260

cagtgcgcca gggcgtgtac cgcatgcgca agaagcagat cgacgtggcc atcaaggtgc   1320

tgaagcaggg cacggagaag gcagacacgg aagagatgat gcgcgaggcg cagatcatgc   1380

accagctgga caacccctac atcgtgcggc tcattggcgt ctgccaggcc gaggccctca   1440

tgctggtcat ggagatggct gggggcgggc cgctgcacaa gttcctggtc ggcaagaggg   1500

aggagatccc tgtgagcaat gtggccgagc tgctgcacca ggtgtccatg gggatgaagt   1560

acctggagga gaagaacttt gtgcaccgtg acctggcggc ccgcaacgtc ctgctggtta   1620

accggcacta cgccaagatc agcgactttg gcctctccaa agcactgggt gccgacgaca   1680

gctactacac tgcccgctca gcagggaagt ggccgctcaa gtggtacgca cccgaatgca   1740

tcaacttccg caagttctcc agccgcagcg atgtctggag ctatggggtc accatgtggg   1800

aggccttgtc ctacggccag aagccctaca agaagatgaa agggccggag gtcatggcct   1860

tcatcgagca gggcaagcgg atggagtgcc caccagagtg tccacccgaa ctgtacgcac   1920

tcatgagtga ctgctggatc tacaagtggg aggatcgccc cgacttcctg accgtggagc   1980

agcgcatgcg agcctgttac tacagcctgg ccagcaaggt ggaagggccc ccaggcagca   2040

cacagaaggc tgaggctgcc tgtgcctgag ctcccgctgc ccaggggagc cctccacgcc   2100

ggctcttccc caccctcagc cccaccccag gtcctgcagt ctggctgagc cctgcttggt   2160

tgtctccaca cacagctggg ctgtggtagg gggtgtctca ggccacaccg gccttgcatt   2220

gcctgcctgg ccccctgtcc tctctggctg gggagcaggg aggtccggga gggtgcggct   2280

gtgcagcctg tcctgggctg gtggctcccg gagggccctg agctgagggc attgcttaca   2340

cggatgcctt cccctgggcc ctgacattgg agcctgggca tcctcaggtg gtcaggcgta   2400

gatcaccaga ataaacccag cttccctctt gtctgagcgc cctcatcttt tccggggtga   2460

gggtaggtgt caggggaggg gtgggttatg aaaagtgcat ggaggtgact gttcttgtgt   2520

ggactgagcc tggaagtgac ccctgggaag atggggctgg gtcccactct ccaccctagg   2580

gacaccttca tgtgagtgag cggctggggt ggagtgggga acctgaggcc aggcgggtgt   2640

gggcccaagg gctgcgtgcc tggctgagcc cagctcccct gtgtggagat gagtgtgccc   2700

catgccaggt gcacgttagg atcacctgga gctattttaa caaacgctaa ccccccctcc   2760

cccatccagc tggggtcttc acccccccag gggtgccttg caaatcatga gatacaatgc   2820

ttttcattgg tagatgcacg tattagctcc cgtatgaacc gtattactga atttgaatct   2880

gaaaaatacc aaaatgcaaa cattgttttt aaattaattg ttttaaaagc taatgaacga   2940

attaagacaa attgcatcaa tttagtggtt tcttaaatcg tggtttgcag gtagttcagt   3000

tttattaaaa ttcatttgtg agtcgctgaa cgacttacat tatgtaaaat atatcagaca   3060

gtaaatgaat tgtggctttc attgcctttt ggtcatc                            3097


<210>  8098
<211>  619
<212>  PRT
<213>  Homosapiens

<400>  8098

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  8099
<211>  2085
<212>  DNA
<213>  Homosapiens

<400>  8099
ggggtctgga ggggcgtggc cgaagagggg cagtcgaggg ttttgggggg ataggaggga     60

ggaaaaggtc gtcttcccca ttcagtcccc tttggaagct ggagaggtgg ggcactggtt    120

ggggaagaac ctgaaaggag gcctcagagg caggggctcc gtggtggcgg tcgccttccg    180

caggctgagc gatgctatgg tgctctacta tgccagatgg gaaggtcttc aagctggaga    240

tgcgcttggg gccgcgctgg aagggcgagg ccctggagca ggccatcatc agccaggccc    300

cgcaggtgga gaagctcatt gctacgacgg cccacgagcg gatgccctgg taccacagca    360

gcctgacgcg tgaggaggcc gagcgcaaac tttactctgg ggcgcagacc gacggcaagt    420

tcctgctgag gccgcggaag gagcagggca catacgccct gtccctcatc tatgggaaga    480

cggtgtacca ctacctcatc agccaagaca aggcgggcaa gtactgcatt cccgagggca    540

ccaagtttga cacgctctgg cagctggtgg agtatctgaa gctgaaggcg gacgggctca    600

tctactgcct gaaggaggcc tgccccaaca gcagtgccag caacgcctca ggggctgctg    660

ctcccacact cccagcccac ccatccacgt tgactcatcc tcagagacga atcgacaccc    720

tcaactcaga tggatacacc cctgagccag cacgcataac gtccccagac aaaccgcggc    780

cgatgcccat ggacacgagc gtgtatgaga gcccctacag cgacccagag gagctcaagg    840

acaagaagct cttcctgaag cgcgataacc tcctcatagc tgacattgaa cttggctgcg    900

gcaactttgg ctcagtgcgc cagggcgtgt accgcatgcg caagaagcag atcgacgtgg    960

ccatcaaggt gctgaagcag ggcacggaga aggcagacac ggaagagatg atgcgcgagg   1020

cgcagatcat gcaccagctg gacaacccct acatcgtgcg gctcattggc gtctgccagg   1080

ccgaggccct catgctggtc atggagatgg ctgggggcgg gccgctgcac aagttcctgg   1140

tcggcaagag ggaggagatc cctgtgagca atgtggccga gctgctgcac caggtgtcca   1200

tggggatgaa gtacctggag gagaagaact ttgtgcaccg tgacctggcg gcccgcaacg   1260

tcctgctggt taaccggcac tacgccaaga tcagcgactt tggcctctcc aaagcactgg   1320

gtgccgacga cagctactac actgcccgct cagcagggaa gtggccgctc aagtggtacg   1380

cacccgaatg catcaacttc cgcaagttct ccagccgcag cgatgtctgg agctatgggg   1440

tcaccatgtg ggaggccttg tcctacggcc agaagcccta caagaagatg aaagggccgg   1500

aggtcatggc cttcatcgag cagggcaagc ggatggagtg cccaccagag tgtccacccg   1560

aactgtacgc actcatgagt gactgctgga tctacaagtg ggaggatcgc cccgacttcc   1620

tgaccgtgga gcagcgcatg cgagcctgtt actacagcct ggccagcaag gtggaagggc   1680

ccccaggcag cacacagaag gctgaggctg cctgtgcctg agctcccgct gcccagggga   1740

gccctccacg ccggctcttc cccaccctca gccccacccc aggtcctgca gtctggctga   1800

gccctgcttg gttgtctcca cacacagctg ggctgtggta gggggtgtct caggccacac   1860

cggccttgca ttgcctgcct ggccccctgt cctctctggc tggggagcag ggaggtccgg   1920

gagggtgcgg ctgtgcagcc tgtcctgggc tggtggctcc cggagggccc tgagctgagg   1980

gcattgctta cacggatgcc ttcccctggg ccctgacatt ggagcctggg catcctcagg   2040

tggtcaggcg tagatcacca gaataaaccc agcttccctc ttgtc                   2085


<210>  8100
<211>  509
<212>  PRT
<213>  Homosapiens

<400>  8100

Met Leu Trp Cys Ser Thr Met Pro Asp Gly Lys Val Phe Lys Leu Glu 
1               5                   10                  15      


Met Arg Leu Gly Pro Arg Trp Lys Gly Glu Ala Leu Glu Gln Ala Ile 
            20                  25                  30          


Ile Ser Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His 
        35                  40                  45              


Glu Arg Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu 
    50                  55                  60                  


Arg Lys Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg 
65                  70                  75                  80  


Pro Arg Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys 
                85                  90                  95      


Thr Val Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys 
            100                 105                 110         


Ile Pro Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr 
        115                 120                 125             


Leu Lys Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys 
    130                 135                 140                 


Pro Asn Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu 
145                 150                 155                 160 


Pro Ala His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr 
                165                 170                 175     


Leu Asn Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro 
            180                 185                 190         


Asp Lys Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro 
        195                 200                 205             


Tyr Ser Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg 
    210                 215                 220                 


Asp Asn Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly 
225                 230                 235                 240 


Ser Val Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val 
                245                 250                 255     


Ala Ile Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu 
            260                 265                 270         


Met Met Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile 
        275                 280                 285             


Val Arg Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met 
    290                 295                 300                 


Glu Met Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg 
305                 310                 315                 320 


Glu Glu Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser 
                325                 330                 335     


Met Gly Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu 
            340                 345                 350         


Ala Ala Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser 
        355                 360                 365             


Asp Phe Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr 
    370                 375                 380                 


Ala Arg Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys 
385                 390                 395                 400 


Ile Asn Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly 
                405                 410                 415     


Val Thr Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys 
            420                 425                 430         


Met Lys Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met 
        435                 440                 445             


Glu Cys Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp 
    450                 455                 460                 


Cys Trp Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu 
465                 470                 475                 480 


Gln Arg Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly 
                485                 490                 495     


Pro Pro Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
            500                 505                 


<210>  8101
<211>  1447
<212>  DNA
<213>  Homosapiens

<400>  8101
tgcatgctcc agggacggca cccttgtctg gggcaggtgc ttgtgggggc tgaggctgcc     60

ttgctcccca cacccctgcc cctgacctgg gagtgtaccg ctgtgtgtgc ccagcacgca    120

taacgtcccc agacaaaccg cggccgatgc ccatggacac gagcgtgtat gagagcccct    180

acagcgaccc agaggagctc aaggacaaga agctcttcct gaagcgcgat aacctcctca    240

tagctgacat tgaacttggc tgcggcaact ttggctcagt gcgccagggc gtgtaccgca    300

tgcgcaagaa gcagatcgac gtggccatca aggtgctgaa gcagggcacg gagaaggcag    360

acacggaaga gatgatgcgc gaggcgcaga tcatgcacca gctggacaac ccctacatcg    420

tgcggctcat tggcgtctgc caggccgagg ccctcatgct ggtcatggag atggctgggg    480

gcgggccgct gcacaagttc ctggtcggca agagggagga gatccctgtg agcaatgtgg    540

ccgagctgct gcaccaggtg tccatgggga tgaagtacct ggaggagaag aactttgtgc    600

accgtgacct ggcggcccgc aacgtcctgc tggttaaccg gcactacgcc aagatcagcg    660

actttggcct ctccaaagca ctgggtgccg acgacagcta ctacactgcc cgctcagcag    720

ggaagtggcc gctcaagtgg tacgcacccg aatgcatcaa cttccgcaag ttctccagcc    780

gcagcgatgt ctggagctat ggggtcacca tgtgggaggc cttgtcctac ggccagaagc    840

cctacaagaa gatgaaaggg ccggaggtca tggccttcat cgagcagggc aagcggatgg    900

agtgcccacc agagtgtcca cccgaactgt acgcactcat gagtgactgc tggatctaca    960

agtgggagga tcgccccgac ttcctgaccg tggagcagcg catgcgagcc tgttactaca   1020

gcctggccag caaggtggaa gggcccccag gcagcacaca gaaggctgag gctgcctgtg   1080

cctgagctcc cgctgcccag gggagccctc cacgccggct cttccccacc ctcagcccca   1140

ccccaggtcc tgcagtctgg ctgagccctg cttggttgtc tccacacaca gctgggctgt   1200

ggtagggggt gtctcaggcc acaccggcct tgcattgcct gcctggcccc ctgtcctctc   1260

tggctgggga gcagggaggt ccgggagggt gcggctgtgc agcctgtcct gggctggtgg   1320

ctcccggagg gccctgagct gagggcattg cttacacgga tgccttcccc tgggccctga   1380

cattggagcc tgggcatcct caggtggtca ggcgtagatc accagaataa acccagcttc   1440

cctcttg                                                             1447


<210>  8102
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  8102

Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser Asp Pro Glu 
1               5                   10                  15      


Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn Leu Leu Ile 
            20                  25                  30          


Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val Arg Gln Gly 
        35                  40                  45              


Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile Lys Val Leu 
    50                  55                  60                  


Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met Arg Glu Ala 
65                  70                  75                  80  


Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg Leu Ile Gly 
                85                  90                  95      


Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met Ala Gly Gly 
            100                 105                 110         


Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu Ile Pro Val 
        115                 120                 125             


Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly Met Lys Tyr 
    130                 135                 140                 


Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
145                 150                 155                 160 


Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe Gly Leu Ser 
                165                 170                 175     


Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg Ser Ala Gly 
            180                 185                 190         


Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn Phe Arg Lys 
        195                 200                 205             


Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr Met Trp Glu 
    210                 215                 220                 


Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys Gly Pro Glu 
225                 230                 235                 240 


Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys Pro Pro Glu 
                245                 250                 255     


Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp Ile Tyr Lys 
            260                 265                 270         


Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg Met Arg Ala 
        275                 280                 285             


Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro Gly Ser Thr 
    290                 295                 300                 


Gln Lys Ala Glu Ala Ala Cys Ala 
305                 310         


<210>  8103
<211>  2113
<212>  DNA
<213>  Homosapiens

<400>  8103
tgcatgctcc agggacggca cccttgtctg gggcaggtgc ttgtgggggc tgaggctgcc     60

ttgctcccca cacccctgcc cctgacctgg gagtgtaccg ctgtgtgtgc ccagcacgca    120

taacgtcccc agacaaaccg cggccgatgc ccatggacac gagcgtgtat gagagcccct    180

acagcgaccc agaggagctc aaggacaaga agctcttcct gaagcgcgat aacctcctca    240

tagctgacat tgaacttggc tgcggcaact ttggctcagt gcgccagggc gtgtaccgca    300

tgcgcaagaa gcagatcgac gtggccatca aggtgctgaa gcagggcacg gagaaggcag    360

acacggaaga gatgatgcgc gaggcgcaga tcatgcacca gctggacaac ccctacatcg    420

tgcggctcat tggcgtctgc caggccgagg ccctcatgct ggtcatggag atggctgggg    480

gcgggccgct gcacaagttc ctggtcggca agagggagga gatccctgtg agcaatgtgg    540

ccgagctgct gcaccaggtg tccatgggga tgaagtacct ggaggagaag aactttgtgc    600

accgtgacct ggcggcccgc aacgtcctgc tggttaaccg gcactacgcc aagatcagcg    660

actttggcct ctccaaagca ctgggtgccg acgacagcta ctacactgcc cgctcagcag    720

ggaagtggcc gctcaagtgg tacgcacccg aatgcatcaa cttccgcaag ttctccagcc    780

gcagcgatgt ctggagctat ggggtcacca tgtgggaggc cttgtcctac ggccagaagc    840

cctacaagaa gatgaaaggg ccggaggtca tggccttcat cgagcagggc aagcggatgg    900

agtgcccacc agagtgtcca cccgaactgt acgcactcat gagtgactgc tggatctaca    960

agtgggagga tcgccccgac ttcctgaccg tggagcagcg catgcgagcc tgttactaca   1020

gcctggccag caaggtggaa gggcccccag gcagcacaca gaaggctgag gctgcctgtg   1080

cctgagctcc cgctgcccag gggagccctc cacgccggct cttccccacc ctcagcccca   1140

ccccaggtcc tgcagtctgg ctgagccctg cttggttgtc tccacacaca gctgggctgt   1200

ggtagggggt gtctcaggcc acaccggcct tgcattgcct gcctggcccc ctgtcctctc   1260

tggctgggga gcagggaggt ccgggagggt gcggctgtgc agcctgtcct gggctggtgg   1320

ctcccggagg gccctgagct gagggcattg cttacacgga tgccttcccc tgggccctga   1380

cattggagcc tgggcatcct caggtggtca ggcgtagatc accagaataa acccagcttc   1440

cctcttgtct gagcgccctc atcttttccg gggtgagggt aggtgtcagg ggaggggtgg   1500

gttatgaaaa gtgcatggag gtgactgttc ttgtgtggac tgagcctgga agtgacccct   1560

gggaagatgg ggctgggtcc cactctccac cctagggaca ccttcatgtg agtgagcggc   1620

tggggtggag tggggaacct gaggccaggc gggtgtgggc ccaagggctg cgtgcctggc   1680

tgagcccagc tcccctgtgt ggagatgagt gtgccccatg ccaggtgcac gttaggatca   1740

cctggagcta ttttaacaaa cgctaacccc ccctccccca tccagctggg gtcttcaccc   1800

ccccaggggt gccttgcaaa tcatgagata caatgctttt cattggtaga tgcacgtatt   1860

agctcccgta tgaaccgtat tactgaattt gaatctgaaa aataccaaaa tgcaaacatt   1920

gtttttaaat taattgtttt aaaagctaat gaacgaatta agacaaattg catcaattta   1980

gtggtttctt aaatcgtggt ttgcaggtag ttcagtttta ttaaaattca tttgtgagtc   2040

gctgaacgac ttacattatg taaaatatat cagacagtaa atgaattgtg gctttcattg   2100

ccttttggtc atc                                                      2113


<210>  8104
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  8104

Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser Asp Pro Glu 
1               5                   10                  15      


Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn Leu Leu Ile 
            20                  25                  30          


Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val Arg Gln Gly 
        35                  40                  45              


Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile Lys Val Leu 
    50                  55                  60                  


Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met Arg Glu Ala 
65                  70                  75                  80  


Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg Leu Ile Gly 
                85                  90                  95      


Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met Ala Gly Gly 
            100                 105                 110         


Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu Ile Pro Val 
        115                 120                 125             


Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly Met Lys Tyr 
    130                 135                 140                 


Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
145                 150                 155                 160 


Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe Gly Leu Ser 
                165                 170                 175     


Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg Ser Ala Gly 
            180                 185                 190         


Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn Phe Arg Lys 
        195                 200                 205             


Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr Met Trp Glu 
    210                 215                 220                 


Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys Gly Pro Glu 
225                 230                 235                 240 


Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys Pro Pro Glu 
                245                 250                 255     


Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp Ile Tyr Lys 
            260                 265                 270         


Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg Met Arg Ala 
        275                 280                 285             


Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro Gly Ser Thr 
    290                 295                 300                 


Gln Lys Ala Glu Ala Ala Cys Ala 
305                 310         


<210>  8105
<211>  708
<212>  DNA
<213>  Homosapiens

<400>  8105
aggtgggaaa actggaaaga ttgaatgtcc tttggagttc acagaggttt ggcagtggga     60

ggagaaaaac aaaacgaagc atagtgggag tgttgaacag actttcccaa gatccccaga    120

tcctgaaatt caagaaaata tttgtcaaag tattagctga gtgcaagcta aggtatcaaa    180

atagtgaata cacacaccaa ggaataatct ttgcaaaaat actttgtctc aagacaaata    240

gaacacagca gactttaata atcaaaacag aaacaccaac atagagaacc taaggaacga    300

agagaatctg atttccaaag tcaccacatt ataaaaatca aatgccaatc ttcaacaaca    360

acgaaaacaa caaaattcac aagacacata aagaaacagg aaaatggctc attcaaagga    420

ataaagtgat taattggcat aaactgtccc tgagaaagcc cagatactaa agtgacttga    480

catttgctca actagataag agtgagtttc gacaaagaag taaaggaaat ttggaacata    540

atattttatc taaaggagaa tatcatcaaa caaagaaatt atataaaaga accacacaaa    600

aattctggag ctgaaaagta cagcaactga agtttttaaa attacttgca gagatcaaca    660

acggatttgc agattagtga actcgaagat aggaaaattg aaattatt                 708


<210>  8106
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  8106

Met Pro Ile Phe Asn Asn Asn Glu Asn Asn Lys Ile His Lys Thr His 
1               5                   10                  15      


Lys Glu Thr Gly Lys Trp Leu Ile Gln Arg Asn Lys Val Ile Asn Trp 
            20                  25                  30          


His Lys Leu Ser Leu Arg Lys Pro Arg Tyr 
        35                  40          


<210>  8107
<211>  2913
<212>  DNA
<213>  Homosapiens

<400>  8107
cttcagtagt atttatttac tccccactct ggtgatcctc tctggtttca cattagcaga     60

gtctgagatg atgaggcttc agggactttg ccatacttgg gcaagggttt cctgacttaa    120

actttttagt tattgaggac tcagatgagt tcattaactg accaaagttt tgatgttttt    180

cacaagcaat tttttaggaa ctgagcgtct tttagtaatg cacgatgtct gggtccatat    240

agttactgta ctaaattaac cattccccaa acccatgatt gcctcgaaac aacagtgcag    300

ggagtctgag gtctaggtgg ccatccgcat cggcattttg gcatgactct gtttaatatt    360

ctcatggccg gttttgtcct catttacata acaaaggcat gctatatttt ttaaaagtca    420

ctttgtcaaa atgacacttg taaagagctt caggttaaag aatgtgatct atgcaatttt    480

gaccttaaaa gttgccagtt tgtcatgtaa aaggcccatg gctctcccgt ctgccccact    540

gaggatgact gcctgagagt cacccttctt ccaactcaga taaaccccac cccccagttt    600

caatattaaa tcatattgtg gatgcaatgg aatggcagct tttaatgtct ttttataaac    660

ctgcacagat gtatgtcatg agtgcactat tgtaatgtag caatactgcc atagtgatga    720

agtgactttt tgctagtttc tataaaggag aaatcatcca aggttagcag ggatttgcat    780

ttgtgcttga tccttgagaa tagaacattt taagcatgtt catatgaaat acgcatttgt    840

cgtaaaggaa aacgcagaaa tatctgattt acgaaatacc ccaataggtt ttttcaattg    900

aaagcaaaac ctatctgcgg ttttcttttg gaagtttatc ctgacccaga gtgacctgct    960

cctcactggt aacgatggag gaggagaagg agaagggtca gagctttaaa agtcttctaa   1020

gaattgtagc tcatggaaaa ttggcgtaga aaaagtgctt gtgcttagca gtgaggtgtc   1080

atttttacga agtaactttg ttttaacaga gccacacttt aaagcttctg aaaataagaa   1140

ccaaaccttg gtaagcgaaa gtttgcttac ttatcttcac cttcatggcc tagttgatca   1200

caatccattt gaaacatcca aatatccctg accgtttcat acgaggtgtt ttggggggtg   1260

gcgactttaa ggttggggga gtagggagtg acgtttctgt ttatttcaac cctcagtatt   1320

gtttgccttt atctgtgatt tgccagtatg gggatcacat actggagttc gttcatttcc   1380

gtggatcttg tttttaaaag taatcatgtg ctttcgtaca ggtcaactac tgggttcaca   1440

ttaaacatga attttctttg gaaacttatg taaactccat cttttttgag tgtatgcctg   1500

ttttaactta tgcttagttt ttaattgtta aaggacttca gaaatgcagt ggcgaactca   1560

gccccatcac tcagcttcca tcctatttaa ctatctccac cacacccaaa aaaagcaaat   1620

cccagacatc aaatatatca tttcatccat aaatactttc gcattgtaaa caccatctta   1680

gtttgtagga ttttgtttcg acattcaatt ttccatttgg gtttttgttt tctcctgggg   1740

gtggtaattt ttcttctggg agggcttcta tgtggtgcgt ggcactagca tattccagca   1800

ggcagagcct cacctgcctc cccttttttt ccagcgatct agtgaatggc ctcgtggctc   1860

tcatgaacag caacgtcagc agcccggtca acctggggaa cccagaagaa cacacaatcc   1920

tagaatttgc tcagttaatt aaaaaccttg ttggtagcgg aagtgaaatt cagtttctct   1980

ccgaagccca ggatgaccca cagaaaagaa aaccagacat caaaaaagca aagctgatgc   2040

tggggtggga gcccgtggtc ccgctggagg aaggtttaaa caaagcaatt cactacttcc   2100

gtaaagaact cgagtaccag gcaaataatc agtacatccc caaaccaaag cctgccagaa   2160

taaagaaagg acggactcgc cacagctgaa ctcctcactt ttaggacaca agactaccat   2220

tgtacacttg atgggatgta tttttggctt ttttttgttg tcgtttaaag aaagacttta   2280

acaggtgtca tgaagaacaa actggaattt cattctgaag cttgctttaa tgaaatggat   2340

gtgcctaaaa gctcccctca aaaaactgca gattttgcct tgcacttttt gaatctctct   2400

ttttatgtaa aatagcgtag atgcatctct gcgtattttc aagttttttt atcttgctgt   2460

gagagcatat gttgtgactg tcgttgacag ttttatttac tggtttcttt gtgaagctga   2520

aaaggaacat taagcgggac aaaaaatgcc gattttattt atgaaagtgg gtacttaata   2580

aatgagtcgt tatactatgc ataaagaaaa atcctagcag tattgtcagg tggtggtgcg   2640

ccggcattga ttttagggca gataaaagaa ttctgtgtga gagctttatg tttctctttt   2700

aattcagagt ttttccaagg tctacttttg agttgcaaac ttgactttga aatattcctg   2760

ttggtcatga tcaaggatat ttgaaatcac tactgtgttt tgctgcgtat ctggggcggg   2820

ggcaggttgg ggggcacaaa gttaacatat tcttggttaa ccatggttaa atatgctatt   2880

ttaataaatt attgaaactc accagtcatg gac                                2913


<210>  8108
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  8108

Met Trp Cys Val Ala Leu Ala Tyr Ser Ser Arg Gln Ser Leu Thr Cys 
1               5                   10                  15      


Leu Pro Phe Phe Ser Ser Asp Leu Val Asn Gly Leu Val Ala Leu Met 
            20                  25                  30          


Asn Ser Asn Val Ser Ser Pro Val Asn Leu Gly Asn Pro Glu Glu His 
        35                  40                  45              


Thr Ile Leu Glu Phe Ala Gln Leu Ile Lys Asn Leu Val Gly Ser Gly 
    50                  55                  60                  


Ser Glu Ile Gln Phe Leu Ser Glu Ala Gln Asp Asp Pro Gln Lys Arg 
65                  70                  75                  80  


Lys Pro Asp Ile Lys Lys Ala Lys Leu Met Leu Gly Trp Glu Pro Val 
                85                  90                  95      


Val Pro Leu Glu Glu Gly Leu Asn Lys Ala Ile His Tyr Phe Arg Lys 
            100                 105                 110         


Glu Leu Glu Tyr Gln Ala Asn Asn Gln Tyr Ile Pro Lys Pro Lys Pro 
        115                 120                 125             


Ala Arg Ile Lys Lys Gly Arg Thr Arg His Ser 
    130                 135                 


<210>  8109
<211>  2000
<212>  DNA
<213>  Homosapiens

<400>  8109
gcgcattgtg cagcaggcgg gcccccgcgc ggtagggccc tggacccgcg cggctcccgg     60

ggatggtgag caaggcgctg ctgcgcctcg tgtctgccgt caaccgcagg aggatgaagc    120

tgctgctggg catcgccttg ctggcctacg tcgcctctgt ttggggcaac ttcgttaata    180

tgagatggtt gaaccactaa gagagaaaat cagagattta gaaaaaagct ttacccagaa    240

atacccacca gtaaagtttt tatcagaaaa ggatcggaaa agaattttga taacaggagg    300

cgcagggttc gtgggctccc atctaactga caaactcatg atggacggcc acgaggtgac    360

cgtggtggac aatttcttca cgggcaggaa gagaaacgtg gagcactgga tcggacatga    420

gaacttcgag ttgattaacc acgacgtggt ggagcccctc tacatcgagg ttgaccagat    480

ataccatctg gcatctccag cctcccctcc aaactacatg tataatccta tcaagacatt    540

aaagaccaat acgattggga cattaaacat gttggggctg gcaaaacgag tcggtgcccg    600

tctgctcctg gcctccacat cggaggtgta tggagatcct gaagtccacc ctcaaagtga    660

ggattactgg ggccacgtga atccaatagg acctcgggcc tgctacgatg aaggcaaacg    720

tgttgcagag accatgtgct atgcctacat gaagcaggaa ggcgtggaag tgcgagtggc    780

cagaatcttc aacacctttg ggccacgcat gcacatgaac gatgggcgag tagtcagcaa    840

cttcatcctg caggcgctcc agggggagcc actcacggta tacggatccg ggtctcagac    900

aagggcgttc cagtacgtca gcgatctagt gaatggcctc gtggctctca tgaacagcaa    960

cgtcagcagc ccggtcaacc tggggaaccc agaagaacac acaatcctag aatttgctca   1020

gttaattaaa aaccttgttg gtagcggaag tgaaattcag tttctctccg aagcccagga   1080

tgacccacag aaaagaaaac cagacatcaa aaaagcaaag ctgatgctgg ggtgggagcc   1140

cgtggtcccg ctggaggaag gtttaaacaa agcaattcac tacttccgta aagaactcga   1200

gtaccaggca aataatcagt acatccccaa accaaagcct gccagaataa agaaaggacg   1260

gactcgccac agctgaactc ctcactttta ggacacaaga ctaccattgt acacttgatg   1320

ggatgtattt ttggcttttt tttgttgtcg tttaaagaaa gactttaaca ggtgtcatga   1380

agaacaaact ggaatttcat tctgaagctt gctttaatga aatggatgtg cctaaaagct   1440

cccctcaaaa aactgcagat tttgccttgc actttttgaa tctctctttt tatgtaaaat   1500

agcgtagatg catctctgcg tattttcaag tttttttatc ttgctgtgag agcatatgtt   1560

gtgactgtcg ttgacagttt tatttactgg tttctttgtg aagctgaaaa ggaacattaa   1620

gcgggacaaa aaatgccgat tttatttatg aaagtgggta cttaataaat gagtcgttat   1680

actatgcata aagaaaaatc ctagcagtat tgtcaggtgg tggtgcgccg gcattgattt   1740

tagggcagat aaaagaattc tgtgtgagag ctttatgttt ctcttttaat tcagagtttt   1800

tccaaggtct acttttgagt tgcaaacttg actttgaaat attcctgttg gtcatgatca   1860

aggatatttg aaatcactac tgtgttttgc tgcgtatctg gggcgggggc aggttggggg   1920

gcacaaagtt aacatattct tggttaacca tggttaaata tgctatttta ataaattatt   1980

gaaactcacc agtcatggac                                               2000


<210>  8110
<211>  363
<212>  PRT
<213>  Homosapiens

<400>  8110

Met Val Glu Pro Leu Arg Glu Lys Ile Arg Asp Leu Glu Lys Ser Phe 
1               5                   10                  15      


Thr Gln Lys Tyr Pro Pro Val Lys Phe Leu Ser Glu Lys Asp Arg Lys 
            20                  25                  30          


Arg Ile Leu Ile Thr Gly Gly Ala Gly Phe Val Gly Ser His Leu Thr 
        35                  40                  45              


Asp Lys Leu Met Met Asp Gly His Glu Val Thr Val Val Asp Asn Phe 
    50                  55                  60                  


Phe Thr Gly Arg Lys Arg Asn Val Glu His Trp Ile Gly His Glu Asn 
65                  70                  75                  80  


Phe Glu Leu Ile Asn His Asp Val Val Glu Pro Leu Tyr Ile Glu Val 
                85                  90                  95      


Asp Gln Ile Tyr His Leu Ala Ser Pro Ala Ser Pro Pro Asn Tyr Met 
            100                 105                 110         


Tyr Asn Pro Ile Lys Thr Leu Lys Thr Asn Thr Ile Gly Thr Leu Asn 
        115                 120                 125             


Met Leu Gly Leu Ala Lys Arg Val Gly Ala Arg Leu Leu Leu Ala Ser 
    130                 135                 140                 


Thr Ser Glu Val Tyr Gly Asp Pro Glu Val His Pro Gln Ser Glu Asp 
145                 150                 155                 160 


Tyr Trp Gly His Val Asn Pro Ile Gly Pro Arg Ala Cys Tyr Asp Glu 
                165                 170                 175     


Gly Lys Arg Val Ala Glu Thr Met Cys Tyr Ala Tyr Met Lys Gln Glu 
            180                 185                 190         


Gly Val Glu Val Arg Val Ala Arg Ile Phe Asn Thr Phe Gly Pro Arg 
        195                 200                 205             


Met His Met Asn Asp Gly Arg Val Val Ser Asn Phe Ile Leu Gln Ala 
    210                 215                 220                 


Leu Gln Gly Glu Pro Leu Thr Val Tyr Gly Ser Gly Ser Gln Thr Arg 
225                 230                 235                 240 


Ala Phe Gln Tyr Val Ser Asp Leu Val Asn Gly Leu Val Ala Leu Met 
                245                 250                 255     


Asn Ser Asn Val Ser Ser Pro Val Asn Leu Gly Asn Pro Glu Glu His 
            260                 265                 270         


Thr Ile Leu Glu Phe Ala Gln Leu Ile Lys Asn Leu Val Gly Ser Gly 
        275                 280                 285             


Ser Glu Ile Gln Phe Leu Ser Glu Ala Gln Asp Asp Pro Gln Lys Arg 
    290                 295                 300                 


Lys Pro Asp Ile Lys Lys Ala Lys Leu Met Leu Gly Trp Glu Pro Val 
305                 310                 315                 320 


Val Pro Leu Glu Glu Gly Leu Asn Lys Ala Ile His Tyr Phe Arg Lys 
                325                 330                 335     


Glu Leu Glu Tyr Gln Ala Asn Asn Gln Tyr Ile Pro Lys Pro Lys Pro 
            340                 345                 350         


Ala Arg Ile Lys Lys Gly Arg Thr Arg His Ser 
        355                 360             


<210>  8111
<211>  2191
<212>  DNA
<213>  Homosapiens

<400>  8111
cggaggggcg ggggcggagc cggaggaagg gggtggaggc gcgcctgcgc ggtgatcccg     60

ccagcaggaa gcaggcgcgc gggggcgggg gcgcgcggcg gcaggaggcg gggctctcgg    120

ggccgctgcc gccgccgccg ccgcgcattg tgcagcaggc gggcccccgc gcggtagggc    180

cctggacccg cgcggctccc ggggatggtg agcaaggcgc tgctgcgcct cgtgtctgcc    240

gtcaaccgca ggaggatgaa gctgctgctg ggcatcgcct tgctggccta cgtcgcctct    300

gtttggggca acttcgttaa tatgaggtct atccaggaaa atggtgaact aaaaattgaa    360

agcaagattg aagagatggt tgaaccacta agagagaaaa tcagagattt agaaaaaagc    420

tttacccaga aatacccacc agtaaagttt ttatcagaaa aggatcggaa aagaattttg    480

ataacaggag gcgcagggtt cgtgggctcc catctaactg acaaactcat gatggacggc    540

cacgaggtga ccgtggtgga caatttcttc acgggcagga agagaaacgt ggagcactgg    600

atcggacatg agaacttcga gttgattaac cacgacgtgg tggagcccct ctacatcgag    660

gttgaccaga tataccatct ggcatctcca gcctcccctc caaactacat gtataatcct    720

atcaagacat taaagaccaa tacgattggg acattaaaca tgttggggct ggcaaaacga    780

gtcggtgccc gtctgctcct ggcctccaca tcggaggtgt atggagatcc tgaagtccac    840

cctcaaagtg aggattactg gggccacgtg aatccaatag gacctcgggc ctgctacgat    900

gaaggcaaac gtgttgcaga gaccatgtgc tatgcctaca tgaagcagga aggcgtggaa    960

gtgcgagtgg ccagaatctt caacaccttt gggccacgca tgcacatgaa cgatgggcga   1020

gtagtcagca acttcatcct gcaggcgctc cagggggagc cactcacggt atacggatcc   1080

gggtctcaga caagggcgtt ccagtacgtc agcgatctag tgaatggcct cgtggctctc   1140

atgaacagca acgtcagcag cccggtcaac ctggggaacc cagaagaaca cacaatccta   1200

gaatttgctc agttaattaa aaaccttgtt ggtagcggaa gtgaaattca gtttctctcc   1260

gaagcccagg atgacccaca gaaaagaaaa ccagacatca aaaaagcaaa gctgatgctg   1320

gggtgggagc ccgtggtccc gctggaggaa ggtttaaaca aagcaattca ctacttccgt   1380

aaagaactcg agtaccaggc aaataatcag tacatcccca aaccaaagcc tgccagaata   1440

aagaaaggac ggactcgcca cagctgaact cctcactttt aggacacaag actaccattg   1500

tacacttgat gggatgtatt tttggctttt ttttgttgtc gtttaaagaa agactttaac   1560

aggtgtcatg aagaacaaac tggaatttca ttctgaagct tgctttaatg aaatggatgt   1620

gcctaaaagc tcccctcaaa aaactgcaga ttttgccttg cactttttga atctctcttt   1680

ttatgtaaaa tagcgtagat gcatctctgc gtattttcaa gtttttttat cttgctgtga   1740

gagcatatgt tgtgactgtc gttgacagtt ttatttactg gtttctttgt gaagctgaaa   1800

aggaacatta agcgggacaa aaaatgccga ttttatttat gaaagtgggt acttaataaa   1860

tgagtcgtta tactatgcat aaagaaaaat cctagcagta ttgtcaggtg gtggtgcgcc   1920

ggcattgatt ttagggcaga taaaagaatt ctgtgtgaga gctttatgtt tctcttttaa   1980

ttcagagttt ttccaaggtc tacttttgag ttgcaaactt gactttgaaa tattcctgtt   2040

ggtcatgatc aaggatattt gaaatcacta ctgtgttttg ctgcgtatct ggggcggggg   2100

caggttgggg ggcacaaagt taacatattc ttggttaacc atggttaaat atgctatttt   2160

aataaattat tgaaactcac cagtcatgga c                                  2191


<210>  8112
<211>  420
<212>  PRT
<213>  Homosapiens

<400>  8112

Met Val Ser Lys Ala Leu Leu Arg Leu Val Ser Ala Val Asn Arg Arg 
1               5                   10                  15      


Arg Met Lys Leu Leu Leu Gly Ile Ala Leu Leu Ala Tyr Val Ala Ser 
            20                  25                  30          


Val Trp Gly Asn Phe Val Asn Met Arg Ser Ile Gln Glu Asn Gly Glu 
        35                  40                  45              


Leu Lys Ile Glu Ser Lys Ile Glu Glu Met Val Glu Pro Leu Arg Glu 
    50                  55                  60                  


Lys Ile Arg Asp Leu Glu Lys Ser Phe Thr Gln Lys Tyr Pro Pro Val 
65                  70                  75                  80  


Lys Phe Leu Ser Glu Lys Asp Arg Lys Arg Ile Leu Ile Thr Gly Gly 
                85                  90                  95      


Ala Gly Phe Val Gly Ser His Leu Thr Asp Lys Leu Met Met Asp Gly 
            100                 105                 110         


His Glu Val Thr Val Val Asp Asn Phe Phe Thr Gly Arg Lys Arg Asn 
        115                 120                 125             


Val Glu His Trp Ile Gly His Glu Asn Phe Glu Leu Ile Asn His Asp 
    130                 135                 140                 


Val Val Glu Pro Leu Tyr Ile Glu Val Asp Gln Ile Tyr His Leu Ala 
145                 150                 155                 160 


Ser Pro Ala Ser Pro Pro Asn Tyr Met Tyr Asn Pro Ile Lys Thr Leu 
                165                 170                 175     


Lys Thr Asn Thr Ile Gly Thr Leu Asn Met Leu Gly Leu Ala Lys Arg 
            180                 185                 190         


Val Gly Ala Arg Leu Leu Leu Ala Ser Thr Ser Glu Val Tyr Gly Asp 
        195                 200                 205             


Pro Glu Val His Pro Gln Ser Glu Asp Tyr Trp Gly His Val Asn Pro 
    210                 215                 220                 


Ile Gly Pro Arg Ala Cys Tyr Asp Glu Gly Lys Arg Val Ala Glu Thr 
225                 230                 235                 240 


Met Cys Tyr Ala Tyr Met Lys Gln Glu Gly Val Glu Val Arg Val Ala 
                245                 250                 255     


Arg Ile Phe Asn Thr Phe Gly Pro Arg Met His Met Asn Asp Gly Arg 
            260                 265                 270         


Val Val Ser Asn Phe Ile Leu Gln Ala Leu Gln Gly Glu Pro Leu Thr 
        275                 280                 285             


Val Tyr Gly Ser Gly Ser Gln Thr Arg Ala Phe Gln Tyr Val Ser Asp 
    290                 295                 300                 


Leu Val Asn Gly Leu Val Ala Leu Met Asn Ser Asn Val Ser Ser Pro 
305                 310                 315                 320 


Val Asn Leu Gly Asn Pro Glu Glu His Thr Ile Leu Glu Phe Ala Gln 
                325                 330                 335     


Leu Ile Lys Asn Leu Val Gly Ser Gly Ser Glu Ile Gln Phe Leu Ser 
            340                 345                 350         


Glu Ala Gln Asp Asp Pro Gln Lys Arg Lys Pro Asp Ile Lys Lys Ala 
        355                 360                 365             


Lys Leu Met Leu Gly Trp Glu Pro Val Val Pro Leu Glu Glu Gly Leu 
    370                 375                 380                 


Asn Lys Ala Ile His Tyr Phe Arg Lys Glu Leu Glu Tyr Gln Ala Asn 
385                 390                 395                 400 


Asn Gln Tyr Ile Pro Lys Pro Lys Pro Ala Arg Ile Lys Lys Gly Arg 
                405                 410                 415     


Thr Arg His Ser 
            420 


<210>  8113
<211>  1924
<212>  DNA
<213>  Homosapiens

<400>  8113
aggataggaa ctggagttat tgttaatgtt acaggaagaa cacattctca aaggagaggg     60

gggtggtggg aaactttgat tttcataggg ttttcagttt cctctcaaat gggaggatgc    120

agcagtgccg ctacttaact gaacgtctcg acagtctgat ggggcggccc tcagccttcc    180

ggagcagcag tgggactgac ctgtccagtg aggaagaaac actgaaccag atggaatggc    240

ctttggggat ggaaaaaccc cagtttacgc tcatctcttc tctcagctaa cttttgtgga    300

gccctgttcc caaactggcc tgggccagag caccgtggag gggtatttgt tgtaaatgga    360

aggtttccag gcccgcctgg aaatcctgaa gggtgagacc tgcagtgggc tcaggagtct    420

gcatttgtgg gtgaccgagg gggcctcccc tccctctaga gtccacactg tggagagcat    480

caggaaggga aaggcctgca tcttgtgctc agtgagctca tcgtctagtg aggaaggcat    540

gtgtgaatct ctggacaagg cagcgctgag ctgttgtgga ctagtggtgc aggcaaggga    600

ttatttctga ccaaggatgg tgagaaggtt tcccatacag actgacgtct ggattgagct    660

ttgaagaaga aagccaggac tggagcagac gacgaggagg gaagagtttg accagatata    720

ccatctggca tctccagcct cccctccaaa ctacatgtat aatcctatca agacattaaa    780

gaccaatacg attgggacat taaacatgtt ggggctggca aaacgagtcg gtgcccgtct    840

gctcctggcc tccacatcgg aggtgtatgg agatcctgaa gtccaccctc aaagtgagga    900

ttactggggc cacgtgaatc caataggacc tcgggcctgc tacgatgaag gcaaacgtgt    960

tgcagagacc atgtgctatg cctacatgaa gcaggaaggc gtggaagtgc gagtggccag   1020

aatcttcaac acctttgggc cacgcatgca catgaacgat gggcgagtag tcagcaactt   1080

catcctgcag gcgctccagg gggagccact cacggtatac ggatccgggt ctcagacaag   1140

ggcgttccag tacgtcagcg atctagtgaa tggcctcgtg gctctcatga acagcaacgt   1200

cagcagcccg gtcaacctgg ggaacccaga agaacacaca atcctagaat ttgctcagtt   1260

aattaaaaac cttgttggta gcggaagtga aattcagttt ctctccgaag cccaggatga   1320

cccacagaaa agaaaaccag acatcaaaaa agcaaagctg atgctggggt gggagcccgt   1380

ggtcccgctg gaggaaggtt taaacaaagc aattcactac ttccgtaaag aactcgagta   1440

ccaggcaaat aatcagtaca tccccaaacc aaagcctgcc agaataaaga aaggacggac   1500

tcgccacagc tgaactcctc acttttagga cacaagacta ccattgtaca cttgatggga   1560

tgtatttttg gctttttttt gttgtcgttt aaagaaagac tttaacaggt gtcatgaaga   1620

acaaactgga atttcattct gaagcttgct ttaatgaaat ggatgtgcct aaaagctccc   1680

ctcaaaaaac tgcagatttt gccttgcact ttttgaatct ctctttttat gtaaaatagc   1740

gtagatgcat ctctgcgtat tttcaagttt ttttatcttg ctgtgagagc atatgttgtg   1800

actgtcgttg acagttttat ttactggttt ctttgtgaag ctgaaaagga acattaagcg   1860

ggacaaaaaa tgccgatttt atttatgaaa gtgggtactt aataaatgag tcgttatact   1920

atgc                                                                1924


<210>  8114
<211>  252
<212>  PRT
<213>  Homosapiens

<400>  8114

Met Tyr Asn Pro Ile Lys Thr Leu Lys Thr Asn Thr Ile Gly Thr Leu 
1               5                   10                  15      


Asn Met Leu Gly Leu Ala Lys Arg Val Gly Ala Arg Leu Leu Leu Ala 
            20                  25                  30          


Ser Thr Ser Glu Val Tyr Gly Asp Pro Glu Val His Pro Gln Ser Glu 
        35                  40                  45              


Asp Tyr Trp Gly His Val Asn Pro Ile Gly Pro Arg Ala Cys Tyr Asp 
    50                  55                  60                  


Glu Gly Lys Arg Val Ala Glu Thr Met Cys Tyr Ala Tyr Met Lys Gln 
65                  70                  75                  80  


Glu Gly Val Glu Val Arg Val Ala Arg Ile Phe Asn Thr Phe Gly Pro 
                85                  90                  95      


Arg Met His Met Asn Asp Gly Arg Val Val Ser Asn Phe Ile Leu Gln 
            100                 105                 110         


Ala Leu Gln Gly Glu Pro Leu Thr Val Tyr Gly Ser Gly Ser Gln Thr 
        115                 120                 125             


Arg Ala Phe Gln Tyr Val Ser Asp Leu Val Asn Gly Leu Val Ala Leu 
    130                 135                 140                 


Met Asn Ser Asn Val Ser Ser Pro Val Asn Leu Gly Asn Pro Glu Glu 
145                 150                 155                 160 


His Thr Ile Leu Glu Phe Ala Gln Leu Ile Lys Asn Leu Val Gly Ser 
                165                 170                 175     


Gly Ser Glu Ile Gln Phe Leu Ser Glu Ala Gln Asp Asp Pro Gln Lys 
            180                 185                 190         


Arg Lys Pro Asp Ile Lys Lys Ala Lys Leu Met Leu Gly Trp Glu Pro 
        195                 200                 205             


Val Val Pro Leu Glu Glu Gly Leu Asn Lys Ala Ile His Tyr Phe Arg 
    210                 215                 220                 


Lys Glu Leu Glu Tyr Gln Ala Asn Asn Gln Tyr Ile Pro Lys Pro Lys 
225                 230                 235                 240 


Pro Ala Arg Ile Lys Lys Gly Arg Thr Arg His Ser 
                245                 250         


<210>  8115
<211>  431
<212>  DNA
<213>  Homosapiens

<400>  8115
caatgagaac tttaatatga ctgaccttca aatcccaaga caggcttgaa gcacatccag     60

actccctctg aaaaagactg ctttgaagtt caaacgtttt ctgctgttgc tttacttcac    120

ttatttattt tggttacagc aactctaaaa agcttaacca aaaagaaact gatggattaa    180

ctccaaattc actcttggcc cttctaaatg cagggcgatg aggaaaccct cagcccccct    240

cagaggagaa gttcccactt gctggccgtc actgcccttc ctgcctggaa ggagtccctc    300

catgttgcag gttactttac aacacacacc cacacctttt ttcccttgaa gctcatcaag    360

tgaagttatc agctctttag agaaatccct tcaattcctc acagtattta aaacaaatta    420

tttttacctg c                                                         431


<210>  8116
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  8116

Met Gln Gly Asp Glu Glu Thr Leu Ser Pro Pro Gln Arg Arg Ser Ser 
1               5                   10                  15      


His Leu Leu Ala Val Thr Ala Leu Pro Ala Trp Lys Glu Ser Leu His 
            20                  25                  30          


Val Ala Gly Tyr Phe Thr Thr His Thr His Thr Phe Phe Pro Leu Lys 
        35                  40                  45              


Leu Ile Lys 
    50      


<210>  8117
<211>  363
<212>  DNA
<213>  Homosapiens

<400>  8117
atggctttct ctgctcgcgc gcagtgtggc ggcagcaggt gcggctttga gatgcagaat     60

gacactggtg agttcatagg cctgtacatg ccatggaaat ggtccaatag caactgcatc    120

atcgatgcca aggaccacaa atccatccag atgaacgggg ccaaggttga caaggtagca    180

ggcaggttta accaccagtt taaaacctat gctatctgca gggccattcg caggatggag    240

ccccttctct ttgatcactt cttccgtggt aacagtgaac agaattctgc tgggagccac    300

agaatgttta ctgaagattt atgggtcacc ggagtaactc caaccaccaa ttcctgtctc    360

tga                                                                  363


<210>  8118
<211>  120
<212>  PRT
<213>  Homosapiens

<400>  8118

Met Ala Phe Ser Ala Arg Ala Gln Cys Gly Gly Ser Arg Cys Gly Phe 
1               5                   10                  15      


Glu Met Gln Asn Asp Thr Gly Glu Phe Ile Gly Leu Tyr Met Pro Trp 
            20                  25                  30          


Lys Trp Ser Asn Ser Asn Cys Ile Ile Asp Ala Lys Asp His Lys Ser 
        35                  40                  45              


Ile Gln Met Asn Gly Ala Lys Val Asp Lys Val Ala Gly Arg Phe Asn 
    50                  55                  60                  


His Gln Phe Lys Thr Tyr Ala Ile Cys Arg Ala Ile Arg Arg Met Glu 
65                  70                  75                  80  


Pro Leu Leu Phe Asp His Phe Phe Arg Gly Asn Ser Glu Gln Asn Ser 
                85                  90                  95      


Ala Gly Ser His Arg Met Phe Thr Glu Asp Leu Trp Val Thr Gly Val 
            100                 105                 110         


Thr Pro Thr Thr Asn Ser Cys Leu 
        115                 120 


<210>  8119
<211>  1180
<212>  DNA
<213>  Homosapiens

<400>  8119
actctcatgt aagtcaacaa catcctggga ctgggacaca ctttctgggc actgctggcc     60

agtcccaaaa tggaacataa ggaagtggtt cttctacttc ttttatttct gaaatcaggt    120

caaggagagc ctctggatga ctatgtaaat gcccaggggg cttcactgtt cagtgtcact    180

aagaagcagc tgggggcagg aagcagagaa gaatgtgcag caaaatgtga ggaggacaaa    240

gaattcacct gcagggcatt ccaatatcac agtaaagagc aacaatgtgt gataatggct    300

gaaaacaaga agtcctccat aatcattagg atgagagatg tagttttatt tgaaaagtaa    360

atgtatcttt cagagtgcaa gactgggaat ggaaagaact acagagggac gatgtccaaa    420

acaaaaaatg gcatcacctg tcaaaaatgg agttccactt ctccccgcag acctaggtaa    480

gactttccct ttcatctttg tgttcatcta ctgtaaagtt gtccctctgt gtctgtgagg    540

gattggttcc aggacccctg tggctaccaa aatccatgct tctcaagtcc cttatgtaaa    600

atggtgcagt atttgcatat aacctacata ccttctcttg tgcaatccct aatataatgt    660

aaatgctatg taatcgttgt tatgctgtat tgtttttatt tgtattatgt tttattgtca    720

tattgttatt ttctctcatc tttttcaagt cttttccatc cacagttggt tgaatttgtg    780

gatgtggaac ccatggatac agagggccaa ctgtatttag gataatttca tcacttttaa    840

ttcaaaccag aatatgtgaa taagcagaca gaaagaatct ttttgatgtc gatgttcaac    900

tatttttggc accatagtag aacatcgttg ctttctattt tttcttgggt atggaggttt    960

cttgaagacc tagaacatag aagaatgcct agttaaaaaa aaaaatcaat gaaactacga   1020

gttttaggcc aaatctgaga aaagaccaaa gatgactatg tttgggactg aagtaaacat   1080

atcaagttag aactctcatc acatgtttga ctcaaattgt ggagcaaaat agtaaataaa   1140

atataaaaat gacaatgaag atacgtgaaa ttcaaatgtc                         1180


<210>  8120
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  8120

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Ala Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Arg Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Lys 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


<210>  8121
<211>  557
<212>  DNA
<213>  Homosapiens

<400>  8121
gcctctggat gactatgtaa atgcccaggg ggcttcactg ttcagtgtca ctaagaagca     60

gctgggggca ggaagcagag aagaatgtgc agcaaaatgt gaggaggaca aagaattcac    120

ctgcagggca ttccaatatc acagtaaaga gcaacaatgt gtgataatgg ctgaaaacaa    180

gaagtcctcc ataatcatta ggatgagaga tgtagtttta tttgaaaagt aaatgtatct    240

ttcagagtgc aagactggga atggaaagaa ctacagaggg acgatgtcca aaacaaaaaa    300

tggcatcacc tgtcaaaaat ggagttccac ttctccccgc agacctagat tctcacctgc    360

tacacacccc tcagagggac tggaggaatc cagacaacga tgcgcagggg ccctggtgtt    420

atactactga tccagaacag agatatgact actgcgacat tcctgagtgt gaagggcagg    480

agtggctcta gaaaatgttt tcatttctgc tcttcacctg taaaataatt tgttgtaaag    540

ccccttccca cagggat                                                   557


<210>  8122
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  8122

Met Glu Arg Thr Thr Glu Gly Arg Cys Pro Lys Gln Lys Met Ala Ser 
1               5                   10                  15      


Pro Val Lys Asn Gly Val Pro Leu Leu Pro Ala Asp Leu Asp Ser His 
            20                  25                  30          


Leu Leu His Thr Pro Gln Arg Asp Trp Arg Asn Pro Asp Asn Asp Ala 
        35                  40                  45              


Gln Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Gln Arg Tyr Asp Tyr 
    50                  55                  60                  


Cys Asp Ile Pro Glu Cys Glu Gly Gln Glu Trp Leu 
65                  70                  75      


<210>  8123
<211>  345
<212>  DNA
<213>  Homosapiens

<400>  8123
ccaatttaaa cttttgtttt gtcatatgca atgattttat tacctgtctt tatttcagag     60

cttatgaatt tttaattatt ctaagggcta acatagaact ttttcatgtt ttctactctt    120

caagagtagg taagacttta gtttgtaata cattacaaaa ggaatcctgt ggttctctaa    180

gagctaattt gtcttggcaa aaggccttag tgagcttgct gggattacag gagtgagcca    240

ccacacccag cctctagtag tacttttatc aaaagtaaat ggaaacatga aattaatttt    300

cacaatacat tttatttaaa ctaatatgtt cacaatgtta aaatt                    345


<210>  8124
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  8124

Asn Leu Asn Phe Cys Phe Val Ile Cys Asn Asp Phe Ile Thr Cys Leu 
1               5                   10                  15      


Tyr Phe Arg Ala Tyr Glu Phe Leu Ile Ile Leu Arg Ala Asn Ile Glu 
            20                  25                  30          


Leu Phe His Val Phe Tyr Ser Ser Arg Val Gly Lys Thr Leu Val Cys 
        35                  40                  45              


Asn Thr Leu Gln Lys Glu Ser Cys Gly Ser Leu Arg Ala Asn Leu Ser 
    50                  55                  60                  


Trp Gln Lys Ala Leu Val Ser Leu Leu Gly Leu Gln Glu 
65                  70                  75          


<210>  8125
<211>  7689
<212>  DNA
<213>  Homosapiens

<400>  8125
atgacgaact tctatgaaga aaggacaacg atgattgcag ccagggattt gcaggaattt     60

gttccttttg gtggagacca ctgcaagcac caccctaatg ctttgaacct tcaacttcgc    120

cagctgcagc cagcttcaga attatggtct tctgatggtg ctgctggctt ggtgggatcc    180

cttcaggagg ttacaatcca cgagaaacag aaggaaaact ggcagttaag gaaaggagta    240

agtgaaattg gagaagatgt ggactatgat gaggaactct atgttgctgg aaatatggtg    300

atatggagca aaggaagtaa aagccaggca ttggcagttt ataaagcatt tacagttgac    360

agtcctgttc agcaggtggg aaaggttttt attcctggac tgccagctcc ctctctgacg    420

atgtccaaca caatgcctcg gcccagtact ccactagatg gcgttagtgc tccaaagcct    480

cttagtaaac tccttggatc attggacgag tggctttcag gcgctttcct cttggaattg    540

gcgactgctg cggggctgag cgctggtctc acgcatctcg ggagccaggt tggtggcgcg    600

atgagttgca gcaaggccta cggggagcgg tacgtcgcct cggtgcaggg ctccgccccg    660

tcgcctcgaa agaagtcaac gagaggattc tattttgcaa agctgtatta tgaagctaaa    720

gaatatgatc ttgctaaaaa atacatatgt acttacatta atgtgcgaga gatggatccc    780

agagctcaca gatttctggg tcttctttat gaattggaag aaaacacaga gaaagccgtt    840

gaatgttaca ggcgttcagt ggaattaaac ccaacacaaa aagatcttgt gttgaagatt    900

gcagaattgc tttgtaaaaa tgatgttact gatggaagag cagaatactg ggtggaaaga    960

gcagcaaaac ttttcccagg aagtcctgca atttataaac taaaggaaca gcttctagat   1020

tgtgaaggtg aagatggatg gaataaactt tttgacttga ttcagtcaga actttatgta   1080

agacctgatg acgtccatgt gaacatccgg ctagtggagt tgtatcgctc aactaaaaga   1140

ttgaaggatg ctgtggcccg ctgccatgag gcagagagga acatagcttt gcgttcaagt   1200

ttagagtgga attcgtgtgt tgtacagacc cttaaggaat atctggagtc tttacagtgt   1260

ttggagtctg ataaaagtga ctggcgagca accaatacag acttactgct ggcctatgct   1320

aatcttatgc ttcttacgct ttccactaga gatgtgcagg aaagtagaga attactggaa   1380

agttttgata gtgctcttca gtctgcgaaa tcttctttgg gtggaaatga tgaactgtca   1440

gctactttct tagaaatgaa aggacatttc tacatgcatg ctggttctct gctcttgaag   1500

atgggtcagc atggtaataa tgttcaatgg cgagctcttt ctgagctggc tgcattgtgc   1560

tatctcatag catttcaggt tccaagacca aagattaaat taataaaagg tgaagctgga   1620

caaaatctgc tggaaatgat ggcctgtgac cgactgagcc aatcagggca catgttgcta   1680

aacttaagtc gtggcaagca agatttttta aaagtggttg ttgaaacttt tgccaacaaa   1740

agcgggcagt ctgcattata tgatgctctg ttttctagtc agtcacctaa ggatacatct   1800

tttcttggta gcgatgatat tggaaacatt gatgtacaag aaccagagct tgaagatttg   1860

gctagatacg atgttggtgc tattcgagca cataatggta gtcttcagca ccttacttgg   1920

cttggcttac agtggaattc attgcctgct ttacctggaa tccgaaaatg gctaaaacag   1980

cttttccatc atttgcccca ggaaacctca aggcttgaaa caaatgcacc tgaatcaata   2040

tgtattttag atcttgaagt atttctcctt ggagtagtat ataccagcca cttacaatta   2100

aaggagaaat gtaattctca ccacagctcc tatcagccgt tatgcctgcc ccttcctgtg   2160

tgtaaacagc tttgtacaga aagacaaaaa tcttggtggg atgcggtttg tactctgatt   2220

cacagaaaag cagtacctgg aaactcagca aaattgagac ttctagttca gcatgaaata   2280

aacactctaa gagcccagga aaaacatggc cttcaacctg ctctgcttgt acattgggca   2340

aaatgccttc agaaaatggg cagcggtctt aattcttttt atgatcaacg agaatacata   2400

gggagaagtg ttcattattg gaagaaagtt ttgccattgt tgaagataat aaaaaagaag   2460

aacagtattc ctgaacctat tgatcctctg tttaaacatt ttcatagtgt agacattcag   2520

gcatcagaaa ttgttgaata tgaagaagac gcacacgtaa cttttgctat attggatgca   2580

gtaaatggaa atatagaaga tgctatgact gcttttgaat ctataaaaag tgttgtttct   2640

tattggaatc ttgcactgat ttttcacagg aaggcagaag acattgcaaa tgatgccctt   2700

tctcctgaag aacaagaaga atgcaaaaat tatctgagaa agaccagggg ctacctaata   2760

aagattttag atgacagtga ttcaaatctt tcagtggtca agaaattgcc tgtgcccctg   2820

gagtctgtaa aagagatgct taagtcagtc atgcaggaac tcgaaaacta tagtgaagga   2880

ggtcctctct ataaaaatgg ttctttgcga aatgcggatt cagaaataaa acattctaca   2940

ccatctccta ccaaatattc actatcacca agtaaaagtt acaagtattc tcccaaaaca   3000

ccacctcgat gggcagaaga tcagaattct ttactgaaaa tgattcgcca agaagtaaag   3060

gccattaagg aagaaatgca ggagttgaaa ctaaatagca gtaagtcagc atcccatcat   3120

cgttggccca cagagaatta tggaccagac tcggtgcctg atggatatca ggggtcacag   3180

acatttcatg gggctccact aacagttgca actactggcc cttcagtata ttatagtcag   3240

tcaccagcat ataattccca gtatcttctc agaccagcag ctaatgttac tcccacaaag   3300

ggttcttcta atacagaatt taagtcaacc aaagaaggat tttccatccc tgtgtctgct   3360

gatggattta aatttggcat ttcggaacca ggaaatcaag aaaagaaaag tgaaaagcct   3420

cttgaaaatg atactggctt acaggctcag gatattagtg gccggaagaa gggccgtggt   3480

gtgatttttg gccaaacaag tagcactttt acatttgcag atgttgcaaa atcaacttca   3540

ggagaaggat ttcagtttgg caaaaaagac ctcaatttca agggattttc aggtgctgga   3600

gaaaaattat tctcatcaca atacggtaaa atggccaata aagcaaacac ttccggtgac   3660

tttgagaaag atgatgatgc ctataagact gaggacagcg atgacatcca ttttgaacca   3720

gtagttcaaa tgcctgaaaa agtagaactt gtaacaggag aagaaggtga aaaagttctg   3780

tattcacagg gggtaaaact atttagattt gatgctgagg taagtcagtg gaaagaaagg   3840

ggcttgggga acttaaaaat tctcaaaaac gaggtcaatg gcaaagtaag aatgctgatg   3900

caaagagaac aagtactaaa agtgtgtgct aatcattgga taacgactac aatgaacctg   3960

aagcccctct ctggatcaga tagagcatgg atgtggtcag ccagtgattt ctctgatggt   4020

gatgccaaac tagagcgatt ggcagcaaaa tttaaaacac cagagctggc tgaagaattc   4080

aagcagaaat ttgaggaatg ccagcggctt ctgttagaca taccacttca aactccccat   4140

aaacttgtag atactggcag agctgccaag ttaatacaga gagctgaaga aatgaagagt   4200

ggactgaaag atttcaaaac atttttgaca aatgatcaaa caaaagtcgc tgaggaagaa   4260

aataagggtt caggtacagg tgcggccggt gcctcagaca caacaataaa acccaatgct   4320

gaaaacactg ggcccacatt agaatgggat aactatgatt taagggaaga tgctttggat   4380

gatagtgtca gtagtagctc agtacatgct tctccattgg caagtagccc tgtgagaaaa   4440

aatcttttcc actttgatga gtcaacaaca ggatctaact tcagttttaa atctgctttg   4500

agtctatcta agtctcctgc caagttgaat cagagtggga cttcagttgg cactgatgaa   4560

gaatctgatg ttactcaaga agaagagaga gatggacagt actttgaacc tgttgttcct   4620

ttacctgatc tagttgaagt atccagtggt gaggaaaatg aacaagttgt ttttagtcac   4680

agggcagaat tctacagata tgataaagat gttggtcaat ggaaagaaag gggcattggt   4740

gatataaaga ttttacagaa ttatgataat aagcacgttc gtatactgat gagaagggac   4800

caagtattaa aactttgtgc caatcacaga ataactccag acatgagttt gcaaaatatg   4860

aaagggacag aaagagtatg ggtgtggact gcatgtgatt ttgcagatgg agaaagaaaa   4920

gtagagcatt tagctgttcg ttttaaacta caggatgttg cagactcgtt taagaaaatt   4980

tttgatgaag caaaaacagc ccaggaaaaa gattctttga taacacctca tgtttctcgg   5040

tcaagcactc ccagagagtc accatgtggc aaaattgctg tagctgtatt agaagaaacc   5100

acaagagaga ggacagatgt tattcagggt gatgatgtag cagatgcagc ttcagaagtt   5160

gaagtgtcta gcacatctga aacaacaaca aaagcagtgg tttctcctcc aaagtttgta   5220

tttggttcag agtctgttaa aagaattttt agtagtgaaa aatcaaaacc atttgcattt   5280

ggcaacagtt ctgccactgg gtctttgttt ggatttagtt ttaatgcacc tttgaaaagt   5340

aacaatagtg aaactagttc agtagcccag agtggatctg aaagcaaagt ggaacctaaa   5400

aaatgtgaac tgtcaaagaa ctctgatatc gaacagtctt cagatagcaa agtcaaaaat   5460

ctctctgctt cctttccaac ggaagaatct tcaatcaact acacatttaa aacaccagaa   5520

aaggagcctc cattatggta tgctgaattt actaaagaag aattggttca gaagctcagt   5580

tccaccacaa aaagtgcaga tcacttaaac ggcctgcttc gggaaataga ggcaaccaat   5640

gcagtcctta tggagcaaat taagcttctc aaaagtgaaa taagaagatt ggaaaggaat   5700

caagagcaag aggtgtctgc agctaacgtg gaacacttga agaacgtctt gctgcagttc   5760

attttcttga agccaggtag tgaaagagag agacttcttc ctgttataaa tacgatgttg   5820

cagctcagcc ttgaagaaaa gggaaaactt gctgcggttg ctcaaggtga ggaataaaat   5880

gcttcccgtt cttctggatg ggcatcctat cttcgtagtt ggtttggact tcgataggtt   5940

gatggaagga atgtttttat taaccaaata aaatctattt acaaaaatgg ttcatgtgta   6000

ttaccatcat tcttttgtca aaaagtgtgt atatgtttgc atttacatat atttgtacat   6060

ctatatgaca gatgtatttt aaaagtttca acttgaagta aaagtacaac agcttgaagt   6120

gttgatacca ggccacagcc ctctaactca tgtgatctcc catgcatgct gccagaataa   6180

aaccaccagg aatgaattca ctccccactt ctctggaacc tcaggacccg cccatttctc   6240

ggcagtactg tgaattttga agttaaacta aattttggta ccataccaac tggaatttag   6300

gctttaaaaa taatgtttca aggccaggtg tggtgattca tgcctgaaat cccactactt   6360

ggggaggctg aggctggaga atcgtttgag gctagtgagc tgtgattgta tcactgcact   6420

ccagctcggg gaacagagcg agaccttgtc tctaaaaata ataatagtaa taaaaataac   6480

attttatgac tatttattgc aaggtcagat ttacagattg ttataaattg ttgagaaatt   6540

tttgtgatta gaatatgaag gaaaaagctt tgttggtaaa agtgacatgt taaggggcta   6600

tgaagtaaat atgctgcagt taattgtgct aagttaaaat acagtttagt tatttgcttt   6660

aaaataaact cttctttttt tctttaaagt atactatctc aaaactcatt atgttgtcag   6720

agccctagag ctggctagtg taacactgac tatgaatagg tgggcccacc acttgagttg   6780

aggtgatttc atggtgtctt tccaggctct tgatagggtg tcactgcatg caagccatga   6840

atctgttttg agaatcctct ccattttccc aaataaaaac ctatcccaac agtgactata   6900

tcactcagca ttgaatctaa atataaaagt ggtgctttca gtgtttttgg cagatagtgt   6960

tccataagct ttccatcaga agggatttta gacaccttag aggtccgtgc tacatcttca   7020

cagttcctct gaataacctt aggtggtagt gttacttgcc tttgacaccg ctgcatatgt   7080

tttaatgact agatccaaac tgtgttgttc ttaaatcaaa aattggataa tttttaatat   7140

ttatgtatta atcacatagt atgctctctg aagttctctt aagccttcag tttatactct   7200

taattttctt tctgagctgg ggaactgact ttgcactttg gttacacaga acattggttt   7260

ccaatttagt ttaactgaaa tttgctgctg atatgttgag tttgttcttt aaaaaatatc   7320

tcatatatct cgtctttcct ccttagaaga acagacctaa ctagcgaatg tatgaatgaa   7380

aatgcatcta tttcagagcc gacatgaaga gtttagtttt tttactttat aaactgtgaa   7440

tatgagtatg ccagctgcat acgatgtaac taatcatatt taaatatatt tcactttctc   7500

tttgacttga gaccttttga agtctgtata aacttgtttt gaaatatagt ctccacttac   7560

aaatgtcata acaaaatact tttttgcatg ataaaaaatt gattacaaaa ggcatattct   7620

ttcatggttt ctgcaatgag aggaagtgta atgattattt taatatttct attaaatatg   7680

tttaactgt                                                           7689


<210>  8126
<211>  1958
<212>  PRT
<213>  Homosapiens

<400>  8126

Met Thr Asn Phe Tyr Glu Glu Arg Thr Thr Met Ile Ala Ala Arg Asp 
1               5                   10                  15      


Leu Gln Glu Phe Val Pro Phe Gly Gly Asp His Cys Lys His His Pro 
            20                  25                  30          


Asn Ala Leu Asn Leu Gln Leu Arg Gln Leu Gln Pro Ala Ser Glu Leu 
        35                  40                  45              


Trp Ser Ser Asp Gly Ala Ala Gly Leu Val Gly Ser Leu Gln Glu Val 
    50                  55                  60                  


Thr Ile His Glu Lys Gln Lys Glu Asn Trp Gln Leu Arg Lys Gly Val 
65                  70                  75                  80  


Ser Glu Ile Gly Glu Asp Val Asp Tyr Asp Glu Glu Leu Tyr Val Ala 
                85                  90                  95      


Gly Asn Met Val Ile Trp Ser Lys Gly Ser Lys Ser Gln Ala Leu Ala 
            100                 105                 110         


Val Tyr Lys Ala Phe Thr Val Asp Ser Pro Val Gln Gln Val Gly Lys 
        115                 120                 125             


Val Phe Ile Pro Gly Leu Pro Ala Pro Ser Leu Thr Met Ser Asn Thr 
    130                 135                 140                 


Met Pro Arg Pro Ser Thr Pro Leu Asp Gly Val Ser Ala Pro Lys Pro 
145                 150                 155                 160 


Leu Ser Lys Leu Leu Gly Ser Leu Asp Glu Trp Leu Ser Gly Ala Phe 
                165                 170                 175     


Leu Leu Glu Leu Ala Thr Ala Ala Gly Leu Ser Ala Gly Leu Thr His 
            180                 185                 190         


Leu Gly Ser Gln Val Gly Gly Ala Met Ser Cys Ser Lys Ala Tyr Gly 
        195                 200                 205             


Glu Arg Tyr Val Ala Ser Val Gln Gly Ser Ala Pro Ser Pro Arg Lys 
    210                 215                 220                 


Lys Ser Thr Arg Gly Phe Tyr Phe Ala Lys Leu Tyr Tyr Glu Ala Lys 
225                 230                 235                 240 


Glu Tyr Asp Leu Ala Lys Lys Tyr Ile Cys Thr Tyr Ile Asn Val Arg 
                245                 250                 255     


Glu Met Asp Pro Arg Ala His Arg Phe Leu Gly Leu Leu Tyr Glu Leu 
            260                 265                 270         


Glu Glu Asn Thr Glu Lys Ala Val Glu Cys Tyr Arg Arg Ser Val Glu 
        275                 280                 285             


Leu Asn Pro Thr Gln Lys Asp Leu Val Leu Lys Ile Ala Glu Leu Leu 
    290                 295                 300                 


Cys Lys Asn Asp Val Thr Asp Gly Arg Ala Glu Tyr Trp Val Glu Arg 
305                 310                 315                 320 


Ala Ala Lys Leu Phe Pro Gly Ser Pro Ala Ile Tyr Lys Leu Lys Glu 
                325                 330                 335     


Gln Leu Leu Asp Cys Glu Gly Glu Asp Gly Trp Asn Lys Leu Phe Asp 
            340                 345                 350         


Leu Ile Gln Ser Glu Leu Tyr Val Arg Pro Asp Asp Val His Val Asn 
        355                 360                 365             


Ile Arg Leu Val Glu Leu Tyr Arg Ser Thr Lys Arg Leu Lys Asp Ala 
    370                 375                 380                 


Val Ala Arg Cys His Glu Ala Glu Arg Asn Ile Ala Leu Arg Ser Ser 
385                 390                 395                 400 


Leu Glu Trp Asn Ser Cys Val Val Gln Thr Leu Lys Glu Tyr Leu Glu 
                405                 410                 415     


Ser Leu Gln Cys Leu Glu Ser Asp Lys Ser Asp Trp Arg Ala Thr Asn 
            420                 425                 430         


Thr Asp Leu Leu Leu Ala Tyr Ala Asn Leu Met Leu Leu Thr Leu Ser 
        435                 440                 445             


Thr Arg Asp Val Gln Glu Ser Arg Glu Leu Leu Glu Ser Phe Asp Ser 
    450                 455                 460                 


Ala Leu Gln Ser Ala Lys Ser Ser Leu Gly Gly Asn Asp Glu Leu Ser 
465                 470                 475                 480 


Ala Thr Phe Leu Glu Met Lys Gly His Phe Tyr Met His Ala Gly Ser 
                485                 490                 495     


Leu Leu Leu Lys Met Gly Gln His Gly Asn Asn Val Gln Trp Arg Ala 
            500                 505                 510         


Leu Ser Glu Leu Ala Ala Leu Cys Tyr Leu Ile Ala Phe Gln Val Pro 
        515                 520                 525             


Arg Pro Lys Ile Lys Leu Ile Lys Gly Glu Ala Gly Gln Asn Leu Leu 
    530                 535                 540                 


Glu Met Met Ala Cys Asp Arg Leu Ser Gln Ser Gly His Met Leu Leu 
545                 550                 555                 560 


Asn Leu Ser Arg Gly Lys Gln Asp Phe Leu Lys Val Val Val Glu Thr 
                565                 570                 575     


Phe Ala Asn Lys Ser Gly Gln Ser Ala Leu Tyr Asp Ala Leu Phe Ser 
            580                 585                 590         


Ser Gln Ser Pro Lys Asp Thr Ser Phe Leu Gly Ser Asp Asp Ile Gly 
        595                 600                 605             


Asn Ile Asp Val Gln Glu Pro Glu Leu Glu Asp Leu Ala Arg Tyr Asp 
    610                 615                 620                 


Val Gly Ala Ile Arg Ala His Asn Gly Ser Leu Gln His Leu Thr Trp 
625                 630                 635                 640 


Leu Gly Leu Gln Trp Asn Ser Leu Pro Ala Leu Pro Gly Ile Arg Lys 
                645                 650                 655     


Trp Leu Lys Gln Leu Phe His His Leu Pro Gln Glu Thr Ser Arg Leu 
            660                 665                 670         


Glu Thr Asn Ala Pro Glu Ser Ile Cys Ile Leu Asp Leu Glu Val Phe 
        675                 680                 685             


Leu Leu Gly Val Val Tyr Thr Ser His Leu Gln Leu Lys Glu Lys Cys 
    690                 695                 700                 


Asn Ser His His Ser Ser Tyr Gln Pro Leu Cys Leu Pro Leu Pro Val 
705                 710                 715                 720 


Cys Lys Gln Leu Cys Thr Glu Arg Gln Lys Ser Trp Trp Asp Ala Val 
                725                 730                 735     


Cys Thr Leu Ile His Arg Lys Ala Val Pro Gly Asn Ser Ala Lys Leu 
            740                 745                 750         


Arg Leu Leu Val Gln His Glu Ile Asn Thr Leu Arg Ala Gln Glu Lys 
        755                 760                 765             


His Gly Leu Gln Pro Ala Leu Leu Val His Trp Ala Lys Cys Leu Gln 
    770                 775                 780                 


Lys Met Gly Ser Gly Leu Asn Ser Phe Tyr Asp Gln Arg Glu Tyr Ile 
785                 790                 795                 800 


Gly Arg Ser Val His Tyr Trp Lys Lys Val Leu Pro Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Lys Lys Asn Ser Ile Pro Glu Pro Ile Asp Pro Leu Phe Lys 
            820                 825                 830         


His Phe His Ser Val Asp Ile Gln Ala Ser Glu Ile Val Glu Tyr Glu 
        835                 840                 845             


Glu Asp Ala His Val Thr Phe Ala Ile Leu Asp Ala Val Asn Gly Asn 
    850                 855                 860                 


Ile Glu Asp Ala Met Thr Ala Phe Glu Ser Ile Lys Ser Val Val Ser 
865                 870                 875                 880 


Tyr Trp Asn Leu Ala Leu Ile Phe His Arg Lys Ala Glu Asp Ile Ala 
                885                 890                 895     


Asn Asp Ala Leu Ser Pro Glu Glu Gln Glu Glu Cys Lys Asn Tyr Leu 
            900                 905                 910         


Arg Lys Thr Arg Gly Tyr Leu Ile Lys Ile Leu Asp Asp Ser Asp Ser 
        915                 920                 925             


Asn Leu Ser Val Val Lys Lys Leu Pro Val Pro Leu Glu Ser Val Lys 
    930                 935                 940                 


Glu Met Leu Lys Ser Val Met Gln Glu Leu Glu Asn Tyr Ser Glu Gly 
945                 950                 955                 960 


Gly Pro Leu Tyr Lys Asn Gly Ser Leu Arg Asn Ala Asp Ser Glu Ile 
                965                 970                 975     


Lys His Ser Thr Pro Ser Pro Thr Lys Tyr Ser Leu Ser Pro Ser Lys 
            980                 985                 990         


Ser Tyr Lys Tyr Ser Pro Lys Thr  Pro Pro Arg Trp Ala  Glu Asp Gln 
        995                 1000                 1005             


Asn Ser  Leu Leu Lys Met Ile  Arg Gln Glu Val Lys  Ala Ile Lys 
    1010                 1015                 1020             


Glu Glu  Met Gln Glu Leu Lys  Leu Asn Ser Ser Lys  Ser Ala Ser 
    1025                 1030                 1035             


His His  Arg Trp Pro Thr Glu  Asn Tyr Gly Pro Asp  Ser Val Pro 
    1040                 1045                 1050             


Asp Gly  Tyr Gln Gly Ser Gln  Thr Phe His Gly Ala  Pro Leu Thr 
    1055                 1060                 1065             


Val Ala  Thr Thr Gly Pro Ser  Val Tyr Tyr Ser Gln  Ser Pro Ala 
    1070                 1075                 1080             


Tyr Asn  Ser Gln Tyr Leu Leu  Arg Pro Ala Ala Asn  Val Thr Pro 
    1085                 1090                 1095             


Thr Lys  Gly Ser Ser Asn Thr  Glu Phe Lys Ser Thr  Lys Glu Gly 
    1100                 1105                 1110             


Phe Ser  Ile Pro Val Ser Ala  Asp Gly Phe Lys Phe  Gly Ile Ser 
    1115                 1120                 1125             


Glu Pro  Gly Asn Gln Glu Lys  Lys Ser Glu Lys Pro  Leu Glu Asn 
    1130                 1135                 1140             


Asp Thr  Gly Leu Gln Ala Gln  Asp Ile Ser Gly Arg  Lys Lys Gly 
    1145                 1150                 1155             


Arg Gly  Val Ile Phe Gly Gln  Thr Ser Ser Thr Phe  Thr Phe Ala 
    1160                 1165                 1170             


Asp Val  Ala Lys Ser Thr Ser  Gly Glu Gly Phe Gln  Phe Gly Lys 
    1175                 1180                 1185             


Lys Asp  Leu Asn Phe Lys Gly  Phe Ser Gly Ala Gly  Glu Lys Leu 
    1190                 1195                 1200             


Phe Ser  Ser Gln Tyr Gly Lys  Met Ala Asn Lys Ala  Asn Thr Ser 
    1205                 1210                 1215             


Gly Asp  Phe Glu Lys Asp Asp  Asp Ala Tyr Lys Thr  Glu Asp Ser 
    1220                 1225                 1230             


Asp Asp  Ile His Phe Glu Pro  Val Val Gln Met Pro  Glu Lys Val 
    1235                 1240                 1245             


Glu Leu  Val Thr Gly Glu Glu  Gly Glu Lys Val Leu  Tyr Ser Gln 
    1250                 1255                 1260             


Gly Val  Lys Leu Phe Arg Phe  Asp Ala Glu Val Ser  Gln Trp Lys 
    1265                 1270                 1275             


Glu Arg  Gly Leu Gly Asn Leu  Lys Ile Leu Lys Asn  Glu Val Asn 
    1280                 1285                 1290             


Gly Lys  Val Arg Met Leu Met  Gln Arg Glu Gln Val  Leu Lys Val 
    1295                 1300                 1305             


Cys Ala  Asn His Trp Ile Thr  Thr Thr Met Asn Leu  Lys Pro Leu 
    1310                 1315                 1320             


Ser Gly  Ser Asp Arg Ala Trp  Met Trp Ser Ala Ser  Asp Phe Ser 
    1325                 1330                 1335             


Asp Gly  Asp Ala Lys Leu Glu  Arg Leu Ala Ala Lys  Phe Lys Thr 
    1340                 1345                 1350             


Pro Glu  Leu Ala Glu Glu Phe  Lys Gln Lys Phe Glu  Glu Cys Gln 
    1355                 1360                 1365             


Arg Leu  Leu Leu Asp Ile Pro  Leu Gln Thr Pro His  Lys Leu Val 
    1370                 1375                 1380             


Asp Thr  Gly Arg Ala Ala Lys  Leu Ile Gln Arg Ala  Glu Glu Met 
    1385                 1390                 1395             


Lys Ser  Gly Leu Lys Asp Phe  Lys Thr Phe Leu Thr  Asn Asp Gln 
    1400                 1405                 1410             


Thr Lys  Val Ala Glu Glu Glu  Asn Lys Gly Ser Gly  Thr Gly Ala 
    1415                 1420                 1425             


Ala Gly  Ala Ser Asp Thr Thr  Ile Lys Pro Asn Ala  Glu Asn Thr 
    1430                 1435                 1440             


Gly Pro  Thr Leu Glu Trp Asp  Asn Tyr Asp Leu Arg  Glu Asp Ala 
    1445                 1450                 1455             


Leu Asp  Asp Ser Val Ser Ser  Ser Ser Val His Ala  Ser Pro Leu 
    1460                 1465                 1470             


Ala Ser  Ser Pro Val Arg Lys  Asn Leu Phe His Phe  Asp Glu Ser 
    1475                 1480                 1485             


Thr Thr  Gly Ser Asn Phe Ser  Phe Lys Ser Ala Leu  Ser Leu Ser 
    1490                 1495                 1500             


Lys Ser  Pro Ala Lys Leu Asn  Gln Ser Gly Thr Ser  Val Gly Thr 
    1505                 1510                 1515             


Asp Glu  Glu Ser Asp Val Thr  Gln Glu Glu Glu Arg  Asp Gly Gln 
    1520                 1525                 1530             


Tyr Phe  Glu Pro Val Val Pro  Leu Pro Asp Leu Val  Glu Val Ser 
    1535                 1540                 1545             


Ser Gly  Glu Glu Asn Glu Gln  Val Val Phe Ser His  Arg Ala Glu 
    1550                 1555                 1560             


Phe Tyr  Arg Tyr Asp Lys Asp  Val Gly Gln Trp Lys  Glu Arg Gly 
    1565                 1570                 1575             


Ile Gly  Asp Ile Lys Ile Leu  Gln Asn Tyr Asp Asn  Lys His Val 
    1580                 1585                 1590             


Arg Ile  Leu Met Arg Arg Asp  Gln Val Leu Lys Leu  Cys Ala Asn 
    1595                 1600                 1605             


His Arg  Ile Thr Pro Asp Met  Ser Leu Gln Asn Met  Lys Gly Thr 
    1610                 1615                 1620             


Glu Arg  Val Trp Val Trp Thr  Ala Cys Asp Phe Ala  Asp Gly Glu 
    1625                 1630                 1635             


Arg Lys  Val Glu His Leu Ala  Val Arg Phe Lys Leu  Gln Asp Val 
    1640                 1645                 1650             


Ala Asp  Ser Phe Lys Lys Ile  Phe Asp Glu Ala Lys  Thr Ala Gln 
    1655                 1660                 1665             


Glu Lys  Asp Ser Leu Ile Thr  Pro His Val Ser Arg  Ser Ser Thr 
    1670                 1675                 1680             


Pro Arg  Glu Ser Pro Cys Gly  Lys Ile Ala Val Ala  Val Leu Glu 
    1685                 1690                 1695             


Glu Thr  Thr Arg Glu Arg Thr  Asp Val Ile Gln Gly  Asp Asp Val 
    1700                 1705                 1710             


Ala Asp  Ala Ala Ser Glu Val  Glu Val Ser Ser Thr  Ser Glu Thr 
    1715                 1720                 1725             


Thr Thr  Lys Ala Val Val Ser  Pro Pro Lys Phe Val  Phe Gly Ser 
    1730                 1735                 1740             


Glu Ser  Val Lys Arg Ile Phe  Ser Ser Glu Lys Ser  Lys Pro Phe 
    1745                 1750                 1755             


Ala Phe  Gly Asn Ser Ser Ala  Thr Gly Ser Leu Phe  Gly Phe Ser 
    1760                 1765                 1770             


Phe Asn  Ala Pro Leu Lys Ser  Asn Asn Ser Glu Thr  Ser Ser Val 
    1775                 1780                 1785             


Ala Gln  Ser Gly Ser Glu Ser  Lys Val Glu Pro Lys  Lys Cys Glu 
    1790                 1795                 1800             


Leu Ser  Lys Asn Ser Asp Ile  Glu Gln Ser Ser Asp  Ser Lys Val 
    1805                 1810                 1815             


Lys Asn  Leu Ser Ala Ser Phe  Pro Thr Glu Glu Ser  Ser Ile Asn 
    1820                 1825                 1830             


Tyr Thr  Phe Lys Thr Pro Glu  Lys Glu Pro Pro Leu  Trp Tyr Ala 
    1835                 1840                 1845             


Glu Phe  Thr Lys Glu Glu Leu  Val Gln Lys Leu Ser  Ser Thr Thr 
    1850                 1855                 1860             


Lys Ser  Ala Asp His Leu Asn  Gly Leu Leu Arg Glu  Ile Glu Ala 
    1865                 1870                 1875             


Thr Asn  Ala Val Leu Met Glu  Gln Ile Lys Leu Leu  Lys Ser Glu 
    1880                 1885                 1890             


Ile Arg  Arg Leu Glu Arg Asn  Gln Glu Gln Glu Val  Ser Ala Ala 
    1895                 1900                 1905             


Asn Val  Glu His Leu Lys Asn  Val Leu Leu Gln Phe  Ile Phe Leu 
    1910                 1915                 1920             


Lys Pro  Gly Ser Glu Arg Glu  Arg Leu Leu Pro Val  Ile Asn Thr 
    1925                 1930                 1935             


Met Leu  Gln Leu Ser Leu Glu  Glu Lys Gly Lys Leu  Ala Ala Val 
    1940                 1945                 1950             


Ala Gln  Gly Glu Glu 
    1955             


<210>  8127
<211>  508
<212>  DNA
<213>  Homosapiens

<400>  8127
tgtttttgag cccaaggaac aagtatttag tcatgattgc cactcgttat aggctctgtt     60

aacagtgtaa agaaagttgg aagttctctc ctgagaagaa gtaacttcaa tgcggaagga    120

cccgggcttc tcatgtttct ctttgtatcc cgaccgccgg gaactgcctt acctgcagct    180

acaaagtcct gcaagtgagg cttagaccca gatcttgtga actgttttca catttcccca    240

tggatgccta gcaagggact gggactgcct gatccgcttt ggtcaagagc acgtgggtgg    300

cctgtgtgca ggcttatcat caataattgc aggacttggt ggagtatggt tgaacaggtg    360

ctcagactgc atgcgtgtct agcgaggcca tcctgaagct gcatgggagt tgtaaaaaag    420

ttaccaacaa gtttttagtt atttgaatag gtttttgaat agatttggaa tgtgggaagc    480

agttgcagaa ataaacgtct taatgact                                       508


<210>  8128
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  8128

Met Pro Ser Lys Gly Leu Gly Leu Pro Asp Pro Leu Trp Ser Arg Ala 
1               5                   10                  15      


Arg Gly Trp Pro Val Cys Arg Leu Ile Ile Asn Asn Cys Arg Thr Trp 
            20                  25                  30          


Trp Ser Met Val Glu Gln Val Leu Arg Leu His Ala Cys Leu Ala Arg 
        35                  40                  45              


Pro Ser 
    50  


<210>  8129
<211>  543
<212>  DNA
<213>  Homosapiens

<400>  8129
gtggaattca tggtggattc ttttgatggg gattttcctg ctttgaaagg aaataatagg     60

acgttttcaa tgtggaacaa ggctgaggtt ctgactgctg gcctaaaaga aacagggtct    120

ttctctgtcc cccaggctgg agggcagtgg tacaatcata gctcactaaa gccttggatt    180

tctgggctca agcagtcctc tctcctcagc ctcccaagta tctaggacta cagccaggat    240

tcccccagtt ggactctcac atacctgtgg acctcaagtg ctccttcata tgtgttttca    300

atgaacttca tccaaaccac atcaaatggc tgtgtataac actaaggaaa tgtcatattg    360

tctcctagtc ctctaccatg tcttttacac acactgaaga tcatgtgaag aaagagagaa    420

gatggtcatc tatacaccaa gttaaacgac cctcagaaga aaccaaccct atggacaact    480

tgatcttgaa cttctagctt tcagacctgt gagaaaataa attgctgttg tttaaattta    540

aaa                                                                  543


<210>  8130
<211>  71
<212>  PRT
<213>  Homosapiens

<400>  8130

Met Val Asp Ser Phe Asp Gly Asp Phe Pro Ala Leu Lys Gly Asn Asn 
1               5                   10                  15      


Arg Thr Phe Ser Met Trp Asn Lys Ala Glu Val Leu Thr Ala Gly Leu 
            20                  25                  30          


Lys Glu Thr Gly Ser Phe Ser Val Pro Gln Ala Gly Gly Gln Trp Tyr 
        35                  40                  45              


Asn His Ser Ser Leu Lys Pro Trp Ile Ser Gly Leu Lys Gln Ser Ser 
    50                  55                  60                  


Leu Leu Ser Leu Pro Ser Ile 
65                  70      


<210>  8131
<211>  1687
<212>  DNA
<213>  Homosapiens

<400>  8131
tgggtttgcc gccagaacac aggtgtcatg aaaactaccc ccaaaagcca aaatgggaaa     60

ggaaaagact cataccaaca ttgtcgtcat tggacacata gattcgggca agtccaccac    120

tactggccat ctgatctaca aaggcggtgg catcgacaaa agaaccattg aaaaatttga    180

gaaggaggct gctgagatgg gaaagggctc cttcaagtat gcctgggtct tggataaact    240

gaaagctgag tgtgaacatg gtatcaccat tgatacctcc ttgtggaaat ttgagaccag    300

caagtactat gtgactatcg ttgatgcccc aggacacaga gacttcatca aaaacatgat    360

tacagagaca tctcaggctg actgtgctgt cctgattgtt gctgctggtg ttggtgaatt    420

tgaagctggt atctccaaga atgggcaaac ccaagagcat gcccttctgg cttacacact    480

gggtgtgaaa caactaattg ttggtgttaa caaaatggat tctactgagc caccctacag    540

ccagaagaga tatgaggaaa attgttaagg aagtcagcac ttacattaag aaaattggct    600

acaaccctga cacagtagca tttgtgccaa tttctggttg gaatggtgac aacatgctgg    660

agccaagtgc taacatgcct tggaaccatg ctgcttgagg ctctggactg catcctacca    720

ccaactcgtc caactgacaa gcccttgcac ctgcctctcc aggatgtcta caaaattggt    780

ggtattggta gtgttcctgt tggccgagtg gagactggtg ttctcaaacc tggtatggtg    840

gtcacctttg ctccagtcaa cgttacaaca gaagtaaaat ctgtcgaaat gcaccatgaa    900

gctttgagtg aagctcttcc tggggacaat gtgggcttca atgtcaagaa tgtgtctgtc    960

aaggatgttc gtcatggcaa cgttgctggt gacagcaaaa atgacccacc aatggaagca   1020

gctggtttca ctgctcaggt gattatcctg aaccatccag gccaaataag cactggctat   1080

gcccctgtat tggattgcca cacggctcat attgcatgca agtttgctga gctgaaggaa   1140

aagattgatc accgttctgg taaaaagctg gaagatggcc ctaaattctt gaagtctgtt   1200

gatgctgcca ttgttgatat ggttcctggc aagcccatgt gtgttgagag cttctcggac   1260

tatccatctt tgggttgctt tgctgttcgt gatatgagac agatagttac agtgggtgtc   1320

atcaaagcag tggacaagaa gactgctgga gctggcaagg tcaccaagtc tgcccagaaa   1380

gctcagaagg ctaaatgaat attatcccta atacctgcca ccccactctt aatcagtgat   1440

ggaagaacag tctcagaact ctgtttcaat tggccattta agtttagtag taaaagactg   1500

gttaatgata acaatgcatc gtaaaacctt cagaaggaaa ggagaatgtt ctgtggacca   1560

ctttggtttt cttttttgcg tgtggcagtt ttaagttact agcttttaaa atcagccctt   1620

tttaatggaa acaacttgac caaaaatttg tcacagaatt ttgagaccca tttaaaaagt   1680

ttaatga                                                             1687


<210>  8132
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  8132

Met Val Thr Thr Cys Trp Ser Gln Val Leu Thr Cys Leu Gly Thr Met 
1               5                   10                  15      


Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg Pro Thr Asp 
            20                  25                  30          


Lys Pro Leu His Leu Pro Leu Gln Asp Val Tyr Lys Ile Gly Gly Ile 
        35                  40                  45              


Gly Ser Val Pro Val Gly Arg Val Glu Thr Gly Val Leu Lys Pro Gly 
    50                  55                  60                  


Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu Val Lys Ser 
65                  70                  75                  80  


Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro Gly Asp Asn 
                85                  90                  95      


Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Val Arg His Gly 
            100                 105                 110         


Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu Ala Ala Gly 
        115                 120                 125             


Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln Ile Ser Thr 
    130                 135                 140                 


Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile Ala Cys Lys 
145                 150                 155                 160 


Phe Ala Glu Leu Lys Glu Lys Ile Asp His Arg Ser Gly Lys Lys Leu 
                165                 170                 175     


Glu Asp Gly Pro Lys Phe Leu Lys Ser Val Asp Ala Ala Ile Val Asp 
            180                 185                 190         


Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser Asp Tyr Pro 
        195                 200                 205             


Ser Leu Gly Cys Phe Ala Val Arg Asp Met Arg Gln Ile Val Thr Val 
    210                 215                 220                 


Gly Val Ile Lys Ala Val Asp Lys Lys Thr Ala Gly Ala Gly Lys Val 
225                 230                 235                 240 


Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Lys 
                245                 250     


<210>  8133
<211>  1392
<212>  DNA
<213>  Homosapiens

<400>  8133
cacaatgggt ttgccgccag aacacaggtg tcatgaaaac tacccccaaa agccaaaatg     60

ggaaaggaaa agactcatac caacattgtc gtcattggac acatagattc gggcaagtcc    120

accactactg gccatctgat ctacaaaggc ggtggcatcg acaaaagaac cattgaaaaa    180

tttgagaagg aggctgctga gatgggaaag ggctccttca agtatgcctg ggtcttggat    240

aaactgaaag ctgagtgtga acatggtatc accattgata cctccttgtg gaaatttgag    300

accagcaagt actatgtgac tatcgttgat gccccaggac acagagactt catcaaaaac    360

atgattacag agacatctca ggctgactgt gctgtcctga ttgttgctgc tggtgttggt    420

gaatttgaag aactaattgt tggtgttaac aaaatggatt ctactgagcc accctacagc    480

cagaagagat atgaggaaaa ttgttaagga agtcagcact tacattaaga aaattggcta    540

caaccctgac acagtagcat ttgtgccaat ttctggttgg aatggtgaca acatgctgga    600

gccaagtgct aacatgcctt ggaaccatgc tgcttgaggc tctggactgc atcctaccac    660

caactcgtcc aactgacaag cccttgcacc tgcctctcca ggatgtctac aaaattggtg    720

gtattggtag tgttcctgtt ggccgagtgg agactggtgt tctcaaacct ggtatggtgg    780

tcacctttgc tccagtcaac gttacaacag aagtaaaatc tgtcgaaatg caccatgaag    840

ctttgagtga agctcttcct ggggacaatg tgggcttcaa tgtcaagaat gtgtctgtca    900

aggatgttcg tcatggcaac gttgctggtg acagcaaaaa tgacccacca atggaagcag    960

ctggtttcac tgctcaggtg attatcctga accatccagg ccaaataagc actggctatg   1020

cccctgtatt ggattgccac acggctcata ttgcatgcaa gtttgctgag ctgaaggaaa   1080

agattgatca ccgttctggt aaaaagctgg aagatggccc taaattcttg aagtctgttg   1140

atgctgccat tgttgatatg gttcctggca agcccatgtg tgttgagagc ttctcggact   1200

atccatcttt gggttgcttt gctgttcgtg atatgagaca gatagttaca gtgggtgtca   1260

tcaaagcagt ggacaagaag actgctggag ctggcaaggt caccaagtct gcccagaaag   1320

ctcagaaggc taaatgaata ttatccctaa tacctgccac cccactctta atcagtgatg   1380

gaagaacagt ct                                                       1392


<210>  8134
<211>  149
<212>  PRT
<213>  Homosapiens

<400>  8134

Met Gly Lys Glu Lys Thr His Thr Asn Ile Val Val Ile Gly His Ile 
1               5                   10                  15      


Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Gly Gly 
            20                  25                  30          


Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
        35                  40                  45              


Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
    50                  55                  60                  


Ala Glu Cys Glu His Gly Ile Thr Ile Asp Thr Ser Leu Trp Lys Phe 
65                  70                  75                  80  


Glu Thr Ser Lys Tyr Tyr Val Thr Ile Val Asp Ala Pro Gly His Arg 
                85                  90                  95      


Asp Phe Ile Lys Asn Met Ile Thr Glu Thr Ser Gln Ala Asp Cys Ala 
            100                 105                 110         


Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Glu Leu Ile Val 
        115                 120                 125             


Gly Val Asn Lys Met Asp Ser Thr Glu Pro Pro Tyr Ser Gln Lys Arg 
    130                 135                 140                 


Tyr Glu Glu Asn Cys 
145                 


<210>  8135
<211>  438
<212>  DNA
<213>  Homosapiens

<400>  8135
aagcttaaac aggtgggggc tggggggaaa tggaaggttg gctctaggac cagatgcatc     60

aggcttcagt gttgtctgtc aacattatcc gtcccttttg agggtagtgt catctgataa    120

catttttgag tcatgggaaa tttccggaaa cagaacagca cacagaaagg actgacctat    180

ttctcttaga gtaacatcct cgtggctcat ccactgattg aagaaatatt tctgttgcta    240

ggagaaagga ccttgaaacc ttgaagtatt ctgtggtatc ctgtgtgtac acagttcttc    300

ttcaaagaga acttagagac atttacttgg gtgacttgac attaaaggga agagattgcc    360

tagagcaggg ggcagcacac tgtggactga gaaccaaatc aagccaggca tctgtttttg    420

caaataaagt tttattag                                                  438


<210>  8136
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  8136

Ser Leu Asn Arg Trp Gly Leu Gly Gly Asn Gly Arg Leu Ala Leu Gly 
1               5                   10                  15      


Pro Asp Ala Ser Gly Phe Ser Val Val Cys Gln His Tyr Pro Ser Leu 
            20                  25                  30          


Leu Arg Val Val Ser Ser Asp Asn Ile Phe Glu Ser Trp Glu Ile Ser 
        35                  40                  45              


Gly Asn Arg Thr Ala His Arg Lys Asp 
    50                  55          


<210>  8137
<211>  984
<212>  DNA
<213>  Homosapiens

<400>  8137
atggcgaaga ttgagaaaaa cgctcccacg atggaaaaaa agccagaact gtttaacatc     60

atggaagtag atggagtccc tacgttgata ttatcaaaag aatggtggga aaaagtatgt    120

aatttccaag ccaagcctga tgatcttatt ctggcaactt acccaaagtc aggtacaaca    180

tggatgcatg aaattttaga catgattcta aatgatggtg atgtggagaa atgcaaaaga    240

gcccagactc tagatagaca cgctttcctt gaactgaaat ttccccataa agaaaaacca    300

gtactagaag atattctcct ggcctcagaa gcagagattg tctatgtggc cagaaatccc    360

aaggattgcc tggtgtccta ctaccacttt cacaggatgg cttcctttat gcctgatcct    420

cagaacttag aggaatttta tgagaaattc atgtccggaa aagttgttgg cgggtcctgg    480

tttgaccatg tgaaaggatg gtgggctgca aaagacatgc accggatcct ctacctcttc    540

tacgaggata ttaaaaaaaa tccaaaacat gagatccaca aggtgttgga attcttggag    600

aaaacttggt caggtgatgt tataaacaag attgtccacc atacctcatt tgatgtaatg    660

aaggataatc ccatggccaa ccatactgcg gacccaaagc gggaaattga gaagatactg    720

aagttcctgg aaaaagacat atcagaggaa attctgaata aaatcatcta tcacacctcc    780

tttgatgtaa tgaagcaaaa cccaatgacc aactatacca ctttgcccac cagcattatg    840

gaccactcca tctccccttt tatgaggaaa gggatgcctg gagactggaa gaactatttt    900

actgtggccc aaaatgaaga atttgacaag gactaccaga agaagatggc aggaagcacc    960

ctaaccttcc gcacagagat ctga                                           984


<210>  8138
<211>  327
<212>  PRT
<213>  Homosapiens

<400>  8138

Met Ala Lys Ile Glu Lys Asn Ala Pro Thr Met Glu Lys Lys Pro Glu 
1               5                   10                  15      


Leu Phe Asn Ile Met Glu Val Asp Gly Val Pro Thr Leu Ile Leu Ser 
            20                  25                  30          


Lys Glu Trp Trp Glu Lys Val Cys Asn Phe Gln Ala Lys Pro Asp Asp 
        35                  40                  45              


Leu Ile Leu Ala Thr Tyr Pro Lys Ser Gly Thr Thr Trp Met His Glu 
    50                  55                  60                  


Ile Leu Asp Met Ile Leu Asn Asp Gly Asp Val Glu Lys Cys Lys Arg 
65                  70                  75                  80  


Ala Gln Thr Leu Asp Arg His Ala Phe Leu Glu Leu Lys Phe Pro His 
                85                  90                  95      


Lys Glu Lys Pro Val Leu Glu Asp Ile Leu Leu Ala Ser Glu Ala Glu 
            100                 105                 110         


Ile Val Tyr Val Ala Arg Asn Pro Lys Asp Cys Leu Val Ser Tyr Tyr 
        115                 120                 125             


His Phe His Arg Met Ala Ser Phe Met Pro Asp Pro Gln Asn Leu Glu 
    130                 135                 140                 


Glu Phe Tyr Glu Lys Phe Met Ser Gly Lys Val Val Gly Gly Ser Trp 
145                 150                 155                 160 


Phe Asp His Val Lys Gly Trp Trp Ala Ala Lys Asp Met His Arg Ile 
                165                 170                 175     


Leu Tyr Leu Phe Tyr Glu Asp Ile Lys Lys Asn Pro Lys His Glu Ile 
            180                 185                 190         


His Lys Val Leu Glu Phe Leu Glu Lys Thr Trp Ser Gly Asp Val Ile 
        195                 200                 205             


Asn Lys Ile Val His His Thr Ser Phe Asp Val Met Lys Asp Asn Pro 
    210                 215                 220                 


Met Ala Asn His Thr Ala Asp Pro Lys Arg Glu Ile Glu Lys Ile Leu 
225                 230                 235                 240 


Lys Phe Leu Glu Lys Asp Ile Ser Glu Glu Ile Leu Asn Lys Ile Ile 
                245                 250                 255     


Tyr His Thr Ser Phe Asp Val Met Lys Gln Asn Pro Met Thr Asn Tyr 
            260                 265                 270         


Thr Thr Leu Pro Thr Ser Ile Met Asp His Ser Ile Ser Pro Phe Met 
        275                 280                 285             


Arg Lys Gly Met Pro Gly Asp Trp Lys Asn Tyr Phe Thr Val Ala Gln 
    290                 295                 300                 


Asn Glu Glu Phe Asp Lys Asp Tyr Gln Lys Lys Met Ala Gly Ser Thr 
305                 310                 315                 320 


Leu Thr Phe Arg Thr Glu Ile 
                325         


<210>  8139
<211>  1638
<212>  DNA
<213>  Homosapiens

<400>  8139
agcttcgagg ccagtgggag gagggagggg ccaggcagct gagggccagg aaagatgtga     60

aaaactctag ctggtgaccg agaggaggag tagagtgtgc ccttagttca tatgaactag    120

agggagttgg tatttgcaca gcagtcaggg tcacatgagt gatcatggta cagtgagaag    180

ttctccctcc cagggccagg tcacagggtt tgtttctgtt caatccggat tcttccagta    240

aaagcttcaa cttcccacac tgaagctgag agcctcccaa agtgctggct acctgctgag    300

cgcccccgta actctgacac agtagtaatt tgagcctctg caattgccgt ctgcttcctg    360

tgaaagtcct ttccgtgccc actgaccctt gagtgggcct ttgagctgct gactttcagc    420

tggaacttga agggacccca accctgagac actatggccc tgacctcaga cctggggaaa    480

cagataaaac tgaaagaggt ggaggggacc ctcctgcagc ctgcaactgt ggacaactgg    540

agccagatcc agagcttcga ggccaaacca gatgatctcc tcatctgcac ctaccctaaa    600

gcagggacaa cgtggattca ggaaattgtg gatatgattg aacagaatgg ggacgtggag    660

aagtgccagc gagccatcat ccaacaccgc catcctttca ttgagtgggc tcggccaccc    720

caaccttctg agacaggatt tcaccatgtt gcccaggctg gtctcaaact cctgagctca    780

agcaatccac ctgcctcaac ctcccaaagt gccaagatta cagacctgct gccaccgtct    840

ttctgggaaa acaactgcaa gttcctttat gtagctcgaa atgccaaaga ctgtatggtt    900

tcctactacc atttccaaag gatgaaccac atgcttcctg accctggtac ctgggaagag    960

tattttgaaa ccttcatcaa tggaaaagtg gtttggggtt cctggtttga ccacgtgaaa   1020

ggatggtggg agatgaaaga cagacaccag attctcttcc tcttctatga ggacataaag   1080

agggacccaa agcatgaaat tcggaaggtg atgcagttca tgggaaagaa ggtggatgaa   1140

acagtgctag ataaaattgt ccaggagacg tcatttgaga aaatgaaaga aaatcccatg   1200

acaaatcgtt ctacagtttc caaatctatc ttggaccagt caatttcctc cttcatgaga   1260

aaaggaactg tgggggattg gaaaaaccac ttcactgttg cccagaatga gaggtttgat   1320

gaaatctata gaagaaagat ggaaggaacc tccataaact tctgcatgga actctgagca   1380

agatgtaaat aaaattaaaa ggtggatggc aagagtgcaa atactatctt caatccttca   1440

gtcccagcca gaagaatctc tgaaagcata ttgtgaatgt atacaatgta gtacaaacaa   1500

tctctgtgat gattaacagt atgtcaccac ttcatttttt aaaaaggatc acgtctaatg   1560

cccattttcc caactattct ttccaaagta agatataagg tagcttaata aactaagtaa   1620

aacgtatgac ttgagtac                                                 1638


<210>  8140
<211>  307
<212>  PRT
<213>  Homosapiens

<400>  8140

Met Ala Leu Thr Ser Asp Leu Gly Lys Gln Ile Lys Leu Lys Glu Val 
1               5                   10                  15      


Glu Gly Thr Leu Leu Gln Pro Ala Thr Val Asp Asn Trp Ser Gln Ile 
            20                  25                  30          


Gln Ser Phe Glu Ala Lys Pro Asp Asp Leu Leu Ile Cys Thr Tyr Pro 
        35                  40                  45              


Lys Ala Gly Thr Thr Trp Ile Gln Glu Ile Val Asp Met Ile Glu Gln 
    50                  55                  60                  


Asn Gly Asp Val Glu Lys Cys Gln Arg Ala Ile Ile Gln His Arg His 
65                  70                  75                  80  


Pro Phe Ile Glu Trp Ala Arg Pro Pro Gln Pro Ser Glu Thr Gly Phe 
                85                  90                  95      


His His Val Ala Gln Ala Gly Leu Lys Leu Leu Ser Ser Ser Asn Pro 
            100                 105                 110         


Pro Ala Ser Thr Ser Gln Ser Ala Lys Ile Thr Asp Leu Leu Pro Pro 
        115                 120                 125             


Ser Phe Trp Glu Asn Asn Cys Lys Phe Leu Tyr Val Ala Arg Asn Ala 
    130                 135                 140                 


Lys Asp Cys Met Val Ser Tyr Tyr His Phe Gln Arg Met Asn His Met 
145                 150                 155                 160 


Leu Pro Asp Pro Gly Thr Trp Glu Glu Tyr Phe Glu Thr Phe Ile Asn 
                165                 170                 175     


Gly Lys Val Val Trp Gly Ser Trp Phe Asp His Val Lys Gly Trp Trp 
            180                 185                 190         


Glu Met Lys Asp Arg His Gln Ile Leu Phe Leu Phe Tyr Glu Asp Ile 
        195                 200                 205             


Lys Arg Asp Pro Lys His Glu Ile Arg Lys Val Met Gln Phe Met Gly 
    210                 215                 220                 


Lys Lys Val Asp Glu Thr Val Leu Asp Lys Ile Val Gln Glu Thr Ser 
225                 230                 235                 240 


Phe Glu Lys Met Lys Glu Asn Pro Met Thr Asn Arg Ser Thr Val Ser 
                245                 250                 255     


Lys Ser Ile Leu Asp Gln Ser Ile Ser Ser Phe Met Arg Lys Gly Thr 
            260                 265                 270         


Val Gly Asp Trp Lys Asn His Phe Thr Val Ala Gln Asn Glu Arg Phe 
        275                 280                 285             


Asp Glu Ile Tyr Arg Arg Lys Met Glu Gly Thr Ser Ile Asn Phe Cys 
    290                 295                 300                 


Met Glu Leu 
305         


<210>  8141
<211>  1605
<212>  DNA
<213>  Homosapiens

<400>  8141
agcttcgagg ccagtgggag gagggagggg ccaggcagct gagggccagg aaagatgtga     60

aaaactctag ctggtgaccg agaggaggag tagagtgtgc ccttagttca tatgaactag    120

agggagttgg tatttgcaca gcagtcaggg tcacatgagt gatcatggta cagtgagaag    180

ttctccctcc cagggccagg tcacagggtt tgtttctgtt caatccggat tcttccagta    240

aaagcttcaa cttcccacac tgaagctgag agcctcccaa agtgctggct acctgctgag    300

cgcccccgta actctgacac agtagtaatt tgagcctctg caattgccgt ctgcttcctg    360

tgaaagtcct ttccgtgccc actgaccctt gagtgggcct ttgagctgct gactttcagc    420

tggaacttga agggacccca accctgagac actatggccc tgacctcaga cctggggaaa    480

cagataaaac tgaaagaggt ggaggggacc ctcctgcagc ctgcaactgt ggacaactgg    540

agccagatcc agagcttcga ggccaaacca gatgatctcc tcatctgcac ctaccctaaa    600

gcagggacaa cgtggattca ggaaattgtg gatatgattg aacagaatgg ggacgtggag    660

aagtgccagc gagccatcat ccaacaccgc catcctttca ttgagtgggc tcggccaccc    720

caaccttctg gtgtggaaaa agccaaagca atgccctctc cacggatact aaagactcac    780

ctttccactc agctgctgcc accgtctttc tgggaaaaca actgcaagtt cctttatgta    840

gctcgaaatg ccaaagactg tatggtttcc tactaccatt tccaaaggat gaaccacatg    900

cttcctgacc ctggtacctg ggaagagtat tttgaaacct tcatcaatgg aaaagtggtt    960

tggggttcct ggtttgacca cgtgaaagga tggtgggaga tgaaagacag acaccagatt   1020

ctcttcctct tctatgagga cataaagagg gacccaaagc atgaaattcg gaaggtgatg   1080

cagttcatgg gaaagaaggt ggatgaaaca gtgctagata aaattgtcca ggagacgtca   1140

tttgagaaaa tgaaagaaaa tcccatgaca aatcgttcta cagtttccaa atctatcttg   1200

gaccagtcaa tttcctcctt catgagaaaa ggaactgtgg gggattggaa aaaccacttc   1260

actgttgccc agaatgagag gtttgatgaa atctatagaa gaaagatgga aggaacctcc   1320

ataaacttct gcatggaact ctgagcaaga tgtaaataaa attaaaaggt ggatggcaag   1380

agtgcaaata ctatcttcaa tccttcagtc ccagccagaa gaatctctga aagcatattg   1440

tgaatgtata caatgtagta caaacaatct ctgtgatgat taacagtatg tcaccacttc   1500

attttttaaa aaggatcacg tctaatgccc attttcccaa ctattctttc caaagtaaga   1560

tataaggtag cttaataaac taagtaaaac gtatgacttg agtac                   1605


<210>  8142
<211>  296
<212>  PRT
<213>  Homosapiens

<400>  8142

Met Ala Leu Thr Ser Asp Leu Gly Lys Gln Ile Lys Leu Lys Glu Val 
1               5                   10                  15      


Glu Gly Thr Leu Leu Gln Pro Ala Thr Val Asp Asn Trp Ser Gln Ile 
            20                  25                  30          


Gln Ser Phe Glu Ala Lys Pro Asp Asp Leu Leu Ile Cys Thr Tyr Pro 
        35                  40                  45              


Lys Ala Gly Thr Thr Trp Ile Gln Glu Ile Val Asp Met Ile Glu Gln 
    50                  55                  60                  


Asn Gly Asp Val Glu Lys Cys Gln Arg Ala Ile Ile Gln His Arg His 
65                  70                  75                  80  


Pro Phe Ile Glu Trp Ala Arg Pro Pro Gln Pro Ser Gly Val Glu Lys 
                85                  90                  95      


Ala Lys Ala Met Pro Ser Pro Arg Ile Leu Lys Thr His Leu Ser Thr 
            100                 105                 110         


Gln Leu Leu Pro Pro Ser Phe Trp Glu Asn Asn Cys Lys Phe Leu Tyr 
        115                 120                 125             


Val Ala Arg Asn Ala Lys Asp Cys Met Val Ser Tyr Tyr His Phe Gln 
    130                 135                 140                 


Arg Met Asn His Met Leu Pro Asp Pro Gly Thr Trp Glu Glu Tyr Phe 
145                 150                 155                 160 


Glu Thr Phe Ile Asn Gly Lys Val Val Trp Gly Ser Trp Phe Asp His 
                165                 170                 175     


Val Lys Gly Trp Trp Glu Met Lys Asp Arg His Gln Ile Leu Phe Leu 
            180                 185                 190         


Phe Tyr Glu Asp Ile Lys Arg Asp Pro Lys His Glu Ile Arg Lys Val 
        195                 200                 205             


Met Gln Phe Met Gly Lys Lys Val Asp Glu Thr Val Leu Asp Lys Ile 
    210                 215                 220                 


Val Gln Glu Thr Ser Phe Glu Lys Met Lys Glu Asn Pro Met Thr Asn 
225                 230                 235                 240 


Arg Ser Thr Val Ser Lys Ser Ile Leu Asp Gln Ser Ile Ser Ser Phe 
                245                 250                 255     


Met Arg Lys Gly Thr Val Gly Asp Trp Lys Asn His Phe Thr Val Ala 
            260                 265                 270         


Gln Asn Glu Arg Phe Asp Glu Ile Tyr Arg Arg Lys Met Glu Gly Thr 
        275                 280                 285             


Ser Ile Asn Phe Cys Met Glu Leu 
    290                 295     


<210>  8143
<211>  2827
<212>  DNA
<213>  Homosapiens

<400>  8143
agcttcgagg ccagtgggag gagggagggg ccaggcagct gagggccagg aaagatgtga     60

aaaactctag ctggtgaccg agaggaggag tagagtgtgc ccttagttca tatgaactag    120

agggagttgg tatttgcaca gcagtcaggg tcacatgagt gatcatggta cagtgagaag    180

ttctccctcc cagggccagg tcacagggtt tgtttctgtt caatccggat tcttccagta    240

aaagcttcaa cttcccacac tgaagctgag agcctcccaa agtgctggct acctgctgag    300

cgcccccgta actctgacac agtagtaatt tgagcctctg caattgccgt ctgcttcctg    360

tgaaagtcct ttccgtgccc actgaccctt gagtgggcct ttgagctgct gactttcagc    420

tggaacttga agggacccca accctgagac actatggccc tgacctcaga cctggggaaa    480

cagataaaac tgaaagaggt ggaggggacc ctcctgcagc ctgcaactgt ggacaactgg    540

agccagatcc agagcttcga ggccaaacca gatgatctcc tcatctgcac ctaccctaaa    600

gcagggacaa cgtggattca ggaaattgtg gatatgattg aacagaatgg ggacgtggag    660

aagtgccagc gagccatcat ccaacaccgc catcctttca ttgagtgggc tcggccaccc    720

caaccttctg agacaggatt tcaccatgtt gcccaggctg gtctcaaact cctgagctca    780

agcaatccac ctgcctcaac ctcccaaagt gccaagatta cagacctgct gccaccgtct    840

ttctgggaaa acaactgcaa gttcctttat gtagctcgaa atgccaaaga ctgtatggtt    900

tcctactacc atttccaaag gatgaaccac atgcttcctg accctggtac ctgggaagag    960

tattttgaaa ccttcatcaa tggaaaagtg gtttggggtt cctggtttga ccacgtgaaa   1020

ggatggtggg agatgaaaga cagacaccag attctcttcc tcttctatga ggacataaag   1080

agggacccaa agcatgaaat tcggaaggtg atgcagttca tgggaaagaa ggtggatgaa   1140

acagtgctag ataaaattgt ccaggagacg tcatttgaga aaatgaaaga aaatcccatg   1200

acaaatcgtt ctacagtttc caaatctatc ttggaccagt caatttcctc cttcatgaga   1260

aaaggaactg tgggggattg gaaaaaccac ttcactgttg cccagaatga gaggtttgat   1320

gaaatctata gaagaaagat ggaaggaacc tccataaact tctgcatgga actctgagca   1380

agatgtaaat aaaattaaaa ggtggatggc aagagtgcaa atactatctt caatccttca   1440

gtcccagcca gaagaatctc tgaaagcata ttgtgaatgt atacaatgta gtacaaacaa   1500

tctctgtgat gattaacagt atgtcaccac ttcatttttt aaaaaggatc acgtctaatg   1560

cccattttcc caactattct ttccaaagta agatataagg tagcttaata aactaagtaa   1620

aacgtatgac ttgagtacaa aaggattgtt ttaatcccca ttattctgga aagtgcatcc   1680

tagtctccca gtctataaca tcataatacc ttgagtataa gtccaaatat taggttatat   1740

ctatattaaa aacaaaattt ctgtcatctg tcctggccat tcaggcaact ccagcctggg   1800

ctcaatcctg gagttctgtc tggtcactat cagaaggaac actttgaggg aaaccctggt   1860

gcagccagcc ctgaggaaac atggcctgag tgccctcact ggtgggtggg aataaaatgg   1920

aagtgcacag aggagatgtc agaagaccaa aacttggtga atagtcccag tgctaggtca   1980

tataggaaac agaaagcatg acagtggcct tttgggaacc caagttacgt cctggtgaaa   2040

gcagaaagga ggagacagga tggctgtcaa caacgtcagc atgggcatgg ctcccaggca   2100

tggaggtaat tgggtcttgg cttcaatgcc acccttttgg gaagccctaa accaagtgag   2160

gtgttctttt cccttgcttc ccatatttgt cccagttgca gccctgttgt tatgtattta   2220

ctcttcaatt tcttatttat acctctcact caattgttaa ttctttgggt tcagtctcat   2280

gccatattta ctcctagtac ctaatgcagt gcctggcaca cagcaagtgc ccttgagaac   2340

ttgtagaggg agtaaaaaag tgcatggata aatgactgca gcaaatcaca aattttgaac   2400

tttgaccctt ttcttttagt cccaaatagt ggcattccat agctgagggt agtaggagca   2460

gttcaccctg ggagcagaca ataagaggaa gaatgaagcc aactaaaatt ctgaatgctt   2520

tttgttggat ttcgtagggt atttttttta aaatagggtc ttgctatgtt gcccaggctg   2580

gtcttaactg actgcttttt attattacca tgcactggca attccaaaca atgtcagtgt   2640

taaaatgctt ctccctgaaa aagagaaaaa aaaaaggaaa aaaagaaaag aaaagtgaaa   2700

agaaaaactc ttattggcct aagttctaaa taatagctag gttaccactg agttttaact   2760

atatgtatat gagcttcaaa taagcacctt tttattatgt aaataaataa aagttatctg   2820

tatcccc                                                             2827


<210>  8144
<211>  307
<212>  PRT
<213>  Homosapiens

<400>  8144

Met Ala Leu Thr Ser Asp Leu Gly Lys Gln Ile Lys Leu Lys Glu Val 
1               5                   10                  15      


Glu Gly Thr Leu Leu Gln Pro Ala Thr Val Asp Asn Trp Ser Gln Ile 
            20                  25                  30          


Gln Ser Phe Glu Ala Lys Pro Asp Asp Leu Leu Ile Cys Thr Tyr Pro 
        35                  40                  45              


Lys Ala Gly Thr Thr Trp Ile Gln Glu Ile Val Asp Met Ile Glu Gln 
    50                  55                  60                  


Asn Gly Asp Val Glu Lys Cys Gln Arg Ala Ile Ile Gln His Arg His 
65                  70                  75                  80  


Pro Phe Ile Glu Trp Ala Arg Pro Pro Gln Pro Ser Glu Thr Gly Phe 
                85                  90                  95      


His His Val Ala Gln Ala Gly Leu Lys Leu Leu Ser Ser Ser Asn Pro 
            100                 105                 110         


Pro Ala Ser Thr Ser Gln Ser Ala Lys Ile Thr Asp Leu Leu Pro Pro 
        115                 120                 125             


Ser Phe Trp Glu Asn Asn Cys Lys Phe Leu Tyr Val Ala Arg Asn Ala 
    130                 135                 140                 


Lys Asp Cys Met Val Ser Tyr Tyr His Phe Gln Arg Met Asn His Met 
145                 150                 155                 160 


Leu Pro Asp Pro Gly Thr Trp Glu Glu Tyr Phe Glu Thr Phe Ile Asn 
                165                 170                 175     


Gly Lys Val Val Trp Gly Ser Trp Phe Asp His Val Lys Gly Trp Trp 
            180                 185                 190         


Glu Met Lys Asp Arg His Gln Ile Leu Phe Leu Phe Tyr Glu Asp Ile 
        195                 200                 205             


Lys Arg Asp Pro Lys His Glu Ile Arg Lys Val Met Gln Phe Met Gly 
    210                 215                 220                 


Lys Lys Val Asp Glu Thr Val Leu Asp Lys Ile Val Gln Glu Thr Ser 
225                 230                 235                 240 


Phe Glu Lys Met Lys Glu Asn Pro Met Thr Asn Arg Ser Thr Val Ser 
                245                 250                 255     


Lys Ser Ile Leu Asp Gln Ser Ile Ser Ser Phe Met Arg Lys Gly Thr 
            260                 265                 270         


Val Gly Asp Trp Lys Asn His Phe Thr Val Ala Gln Asn Glu Arg Phe 
        275                 280                 285             


Asp Glu Ile Tyr Arg Arg Lys Met Glu Gly Thr Ser Ile Asn Phe Cys 
    290                 295                 300                 


Met Glu Leu 
305         


<210>  8145
<211>  2794
<212>  DNA
<213>  Homosapiens

<400>  8145
agcttcgagg ccagtgggag gagggagggg ccaggcagct gagggccagg aaagatgtga     60

aaaactctag ctggtgaccg agaggaggag tagagtgtgc ccttagttca tatgaactag    120

agggagttgg tatttgcaca gcagtcaggg tcacatgagt gatcatggta cagtgagaag    180

ttctccctcc cagggccagg tcacagggtt tgtttctgtt caatccggat tcttccagta    240

aaagcttcaa cttcccacac tgaagctgag agcctcccaa agtgctggct acctgctgag    300

cgcccccgta actctgacac agtagtaatt tgagcctctg caattgccgt ctgcttcctg    360

tgaaagtcct ttccgtgccc actgaccctt gagtgggcct ttgagctgct gactttcagc    420

tggaacttga agggacccca accctgagac actatggccc tgacctcaga cctggggaaa    480

cagataaaac tgaaagaggt ggaggggacc ctcctgcagc ctgcaactgt ggacaactgg    540

agccagatcc agagcttcga ggccaaacca gatgatctcc tcatctgcac ctaccctaaa    600

gcagggacaa cgtggattca ggaaattgtg gatatgattg aacagaatgg ggacgtggag    660

aagtgccagc gagccatcat ccaacaccgc catcctttca ttgagtgggc tcggccaccc    720

caaccttctg gtgtggaaaa agccaaagca atgccctctc cacggatact aaagactcac    780

ctttccactc agctgctgcc accgtctttc tgggaaaaca actgcaagtt cctttatgta    840

gctcgaaatg ccaaagactg tatggtttcc tactaccatt tccaaaggat gaaccacatg    900

cttcctgacc ctggtacctg ggaagagtat tttgaaacct tcatcaatgg aaaagtggtt    960

tggggttcct ggtttgacca cgtgaaagga tggtgggaga tgaaagacag acaccagatt   1020

ctcttcctct tctatgagga cataaagagg gacccaaagc atgaaattcg gaaggtgatg   1080

cagttcatgg gaaagaaggt ggatgaaaca gtgctagata aaattgtcca ggagacgtca   1140

tttgagaaaa tgaaagaaaa tcccatgaca aatcgttcta cagtttccaa atctatcttg   1200

gaccagtcaa tttcctcctt catgagaaaa ggaactgtgg gggattggaa aaaccacttc   1260

actgttgccc agaatgagag gtttgatgaa atctatagaa gaaagatgga aggaacctcc   1320

ataaacttct gcatggaact ctgagcaaga tgtaaataaa attaaaaggt ggatggcaag   1380

agtgcaaata ctatcttcaa tccttcagtc ccagccagaa gaatctctga aagcatattg   1440

tgaatgtata caatgtagta caaacaatct ctgtgatgat taacagtatg tcaccacttc   1500

attttttaaa aaggatcacg tctaatgccc attttcccaa ctattctttc caaagtaaga   1560

tataaggtag cttaataaac taagtaaaac gtatgacttg agtacaaaag gattgtttta   1620

atccccatta ttctggaaag tgcatcctag tctcccagtc tataacatca taataccttg   1680

agtataagtc caaatattag gttatatcta tattaaaaac aaaatttctg tcatctgtcc   1740

tggccattca ggcaactcca gcctgggctc aatcctggag ttctgtctgg tcactatcag   1800

aaggaacact ttgagggaaa ccctggtgca gccagccctg aggaaacatg gcctgagtgc   1860

cctcactggt gggtgggaat aaaatggaag tgcacagagg agatgtcaga agaccaaaac   1920

ttggtgaata gtcccagtgc taggtcatat aggaaacaga aagcatgaca gtggcctttt   1980

gggaacccaa gttacgtcct ggtgaaagca gaaaggagga gacaggatgg ctgtcaacaa   2040

cgtcagcatg ggcatggctc ccaggcatgg aggtaattgg gtcttggctt caatgccacc   2100

cttttgggaa gccctaaacc aagtgaggtg ttcttttccc ttgcttccca tatttgtccc   2160

agttgcagcc ctgttgttat gtatttactc ttcaatttct tatttatacc tctcactcaa   2220

ttgttaattc tttgggttca gtctcatgcc atatttactc ctagtaccta atgcagtgcc   2280

tggcacacag caagtgccct tgagaacttg tagagggagt aaaaaagtgc atggataaat   2340

gactgcagca aatcacaaat tttgaacttt gacccttttc ttttagtccc aaatagtggc   2400

attccatagc tgagggtagt aggagcagtt caccctggga gcagacaata agaggaagaa   2460

tgaagccaac taaaattctg aatgcttttt gttggatttc gtagggtatt ttttttaaaa   2520

tagggtcttg ctatgttgcc caggctggtc ttaactgact gctttttatt attaccatgc   2580

actggcaatt ccaaacaatg tcagtgttaa aatgcttctc cctgaaaaag agaaaaaaaa   2640

aaggaaaaaa agaaaagaaa agtgaaaaga aaaactctta ttggcctaag ttctaaataa   2700

tagctaggtt accactgagt tttaactata tgtatatgag cttcaaataa gcaccttttt   2760

attatgtaaa taaataaaag ttatctgtat cccc                               2794


<210>  8146
<211>  296
<212>  PRT
<213>  Homosapiens

<400>  8146

Met Ala Leu Thr Ser Asp Leu Gly Lys Gln Ile Lys Leu Lys Glu Val 
1               5                   10                  15      


Glu Gly Thr Leu Leu Gln Pro Ala Thr Val Asp Asn Trp Ser Gln Ile 
            20                  25                  30          


Gln Ser Phe Glu Ala Lys Pro Asp Asp Leu Leu Ile Cys Thr Tyr Pro 
        35                  40                  45              


Lys Ala Gly Thr Thr Trp Ile Gln Glu Ile Val Asp Met Ile Glu Gln 
    50                  55                  60                  


Asn Gly Asp Val Glu Lys Cys Gln Arg Ala Ile Ile Gln His Arg His 
65                  70                  75                  80  


Pro Phe Ile Glu Trp Ala Arg Pro Pro Gln Pro Ser Gly Val Glu Lys 
                85                  90                  95      


Ala Lys Ala Met Pro Ser Pro Arg Ile Leu Lys Thr His Leu Ser Thr 
            100                 105                 110         


Gln Leu Leu Pro Pro Ser Phe Trp Glu Asn Asn Cys Lys Phe Leu Tyr 
        115                 120                 125             


Val Ala Arg Asn Ala Lys Asp Cys Met Val Ser Tyr Tyr His Phe Gln 
    130                 135                 140                 


Arg Met Asn His Met Leu Pro Asp Pro Gly Thr Trp Glu Glu Tyr Phe 
145                 150                 155                 160 


Glu Thr Phe Ile Asn Gly Lys Val Val Trp Gly Ser Trp Phe Asp His 
                165                 170                 175     


Val Lys Gly Trp Trp Glu Met Lys Asp Arg His Gln Ile Leu Phe Leu 
            180                 185                 190         


Phe Tyr Glu Asp Ile Lys Arg Asp Pro Lys His Glu Ile Arg Lys Val 
        195                 200                 205             


Met Gln Phe Met Gly Lys Lys Val Asp Glu Thr Val Leu Asp Lys Ile 
    210                 215                 220                 


Val Gln Glu Thr Ser Phe Glu Lys Met Lys Glu Asn Pro Met Thr Asn 
225                 230                 235                 240 


Arg Ser Thr Val Ser Lys Ser Ile Leu Asp Gln Ser Ile Ser Ser Phe 
                245                 250                 255     


Met Arg Lys Gly Thr Val Gly Asp Trp Lys Asn His Phe Thr Val Ala 
            260                 265                 270         


Gln Asn Glu Arg Phe Asp Glu Ile Tyr Arg Arg Lys Met Glu Gly Thr 
        275                 280                 285             


Ser Ile Asn Phe Cys Met Glu Leu 
    290                 295     


<210>  8147
<211>  1449
<212>  DNA
<213>  Homosapiens

<400>  8147
ccaggaaaga tgtgaaaaac tctagctggt gaccgagagg aggagtagag tgtgccctta     60

gttcatatga actagaggga gttggtattt gcacagcagt cagggtcaca tgagtgatca    120

tggtacagtg agaagttctc cctcccaggg ccaggtcaca gggtttgttt ctgttcaatc    180

cggattcttc cagtaaaagc ttcaacttcc cacactgaag ctgagagcct cccaaagtgc    240

tggctacctg ctgagcgccc ccgtaactct gacacagtag taatttgagc ctctgcaatt    300

gccgtctgct tcctgtgaaa gtcctttccg tgcccactga cccttgagtg ggcctttgag    360

ctgctgactt tcagctggaa cttgaaggga ccccaaccct gagacactat ggccctgacc    420

tcagacctgg ggaaacagat aaaactgaaa gaggtggagg ggaccctcct gcagcctgca    480

actgtggaca actggagcca gatccagagc ttcgaggcca aaccagatga tctcctcatc    540

tgcacctacc ctaaagcagg gacaacgtgg attcaggaaa ttgtggatat gattgaacag    600

aatggggacg tggagaagtg ccagcgagcc atcatccaac accgccatcc tttcattgag    660

tgggctcggc caccccaacc ttctgctcga aatgccaaag actgtatggt ttcctactac    720

catttccaaa ggatgaacca catgcttcct gaccctggta cctgggaaga gtattttgaa    780

accttcatca atggaaaagt ggtttggggt tcctggtttg accacgtgaa aggatggtgg    840

gagatgaaag acagacacca gattctcttc ctcttctatg aggacataaa gagggaccca    900

aagcatgaaa ttcggaaggt gatgcagttc atgggaaaga aggtggatga aacagtgcta    960

gataaaattg tccaggagac gtcatttgag aaaatgaaag aaaatcccat gacaaatcgt   1020

tctacagttt ccaaatctat cttggaccag tcaatttcct ccttcatgag aaaaggaact   1080

gtgggggatt ggaaaaacca cttcactgtt gcccagaatg agaggtttga tgaaatctat   1140

agaagaaaga tggaaggaac ctccataaac ttctgcatgg aactctgagc aagatgtaaa   1200

taaaattaaa aggtggatgg caagagtgca aatactatct tcaatccttc agtcccagcc   1260

agaagaatct ctgaaagcat attgtgaatg tatacaatgt agtacaaaca atctctgtga   1320

tgattaacag tatgtcacca cttcattttt taaaaaggat cacgtctaat gcccattttc   1380

ccaactattc tttccaaagt aagatataag gtagcttaat aaactaagta aaacgtatga   1440

cttgagtac                                                           1449


<210>  8148
<211>  259
<212>  PRT
<213>  Homosapiens

<400>  8148

Met Ala Leu Thr Ser Asp Leu Gly Lys Gln Ile Lys Leu Lys Glu Val 
1               5                   10                  15      


Glu Gly Thr Leu Leu Gln Pro Ala Thr Val Asp Asn Trp Ser Gln Ile 
            20                  25                  30          


Gln Ser Phe Glu Ala Lys Pro Asp Asp Leu Leu Ile Cys Thr Tyr Pro 
        35                  40                  45              


Lys Ala Gly Thr Thr Trp Ile Gln Glu Ile Val Asp Met Ile Glu Gln 
    50                  55                  60                  


Asn Gly Asp Val Glu Lys Cys Gln Arg Ala Ile Ile Gln His Arg His 
65                  70                  75                  80  


Pro Phe Ile Glu Trp Ala Arg Pro Pro Gln Pro Ser Ala Arg Asn Ala 
                85                  90                  95      


Lys Asp Cys Met Val Ser Tyr Tyr His Phe Gln Arg Met Asn His Met 
            100                 105                 110         


Leu Pro Asp Pro Gly Thr Trp Glu Glu Tyr Phe Glu Thr Phe Ile Asn 
        115                 120                 125             


Gly Lys Val Val Trp Gly Ser Trp Phe Asp His Val Lys Gly Trp Trp 
    130                 135                 140                 


Glu Met Lys Asp Arg His Gln Ile Leu Phe Leu Phe Tyr Glu Asp Ile 
145                 150                 155                 160 


Lys Arg Asp Pro Lys His Glu Ile Arg Lys Val Met Gln Phe Met Gly 
                165                 170                 175     


Lys Lys Val Asp Glu Thr Val Leu Asp Lys Ile Val Gln Glu Thr Ser 
            180                 185                 190         


Phe Glu Lys Met Lys Glu Asn Pro Met Thr Asn Arg Ser Thr Val Ser 
        195                 200                 205             


Lys Ser Ile Leu Asp Gln Ser Ile Ser Ser Phe Met Arg Lys Gly Thr 
    210                 215                 220                 


Val Gly Asp Trp Lys Asn His Phe Thr Val Ala Gln Asn Glu Arg Phe 
225                 230                 235                 240 


Asp Glu Ile Tyr Arg Arg Lys Met Glu Gly Thr Ser Ile Asn Phe Cys 
                245                 250                 255     


Met Glu Leu 
            


<210>  8149
<211>  1602
<212>  DNA
<213>  Homosapiens

<400>  8149
ccaggaaaga tgtgaaaaac tctagctggt gaccgagagg aggagtagag tgtgccctta     60

gttcatatga actagaggga gttggtattt gcacagcagt cagggtcaca tgagtgatca    120

tggtacagtg agaagttctc cctcccaggg ccaggtcaca gggtttgttt ctgttcaatc    180

cggattcttc cagtaaaagc ttcaacttcc cacactgaag ctgagagcct cccaaagtgc    240

tggctacctg ctgagcgccc ccgtaactct gacacagtag taatttgagc ctctgcaatt    300

gccgtctgct tcctgtgaaa gtcctttccg tgcccactga cccttgagtg ggcctttgag    360

ctgctgactt tcagctggaa cttgaaggga ccccaaccct gagacactat ggccctgacc    420

tcagacctgg ggaaacagat aaaactgaaa gaggtggagg ggaccctcct gcagcctgca    480

actgtggaca actggagcca gatccagagc ttcgaggcca aaccagatga tctcctcatc    540

tgcacctacc ctaaagcagg gacaacgtgg attcaggaaa ttgtggatat gattgaacag    600

aatggggacg tggagaagtg ccagcgagcc atcatccaac accgccatcc tttcattgag    660

tgggctcggc caccccaacc ttctgtgctt gtactacgca gatgtttcct cttgagctat    720

tttaaaggtg tggaaaaagc caaagcaatg ccctctccac ggatactaaa gactcacctt    780

tccactcagc tgctgccacc gtctttctgg gaaaacaact gcaagttcct ttatgtagct    840

cgaaatgcca aagactgtat ggtttcctac taccatttcc aaaggatgaa ccacatgctt    900

cctgaccctg gtacctggga agagtatttt gaaaccttca tcaatggaaa agtggtttgg    960

ggttcctggt ttgaccacgt gaaaggatgg tgggagatga aagacagaca ccagattctc   1020

ttcctcttct atgaggacat aaagagggac ccaaagcatg aaattcggaa ggtgatgcag   1080

ttcatgggaa agaaggtgga tgaaacagtg ctagataaaa ttgtccagga gacgtcattt   1140

gagaaaatga aagaaaatcc catgacaaat cgttctacag tttccaaatc tatcttggac   1200

cagtcaattt cctccttcat gagaaaagga actgtggggg attggaaaaa ccacttcact   1260

gttgcccaga atgagaggtt tgatgaaatc tatagaagaa agatggaagg aacctccata   1320

aacttctgca tggaactctg agcaagatgt aaataaaatt aaaaggtgga tggcaagagt   1380

gcaaatacta tcttcaatcc ttcagtccca gccagaagaa tctctgaaag catattgtga   1440

atgtatacaa tgtagtacaa acaatctctg tgatgattaa cagtatgtca ccacttcatt   1500

ttttaaaaag gatcacgtct aatgcccatt ttcccaacta ttctttccaa agtaagatat   1560

aaggtagctt aataaactaa gtaaaacgta tgacttgagt ac                      1602


<210>  8150
<211>  310
<212>  PRT
<213>  Homosapiens

<400>  8150

Met Ala Leu Thr Ser Asp Leu Gly Lys Gln Ile Lys Leu Lys Glu Val 
1               5                   10                  15      


Glu Gly Thr Leu Leu Gln Pro Ala Thr Val Asp Asn Trp Ser Gln Ile 
            20                  25                  30          


Gln Ser Phe Glu Ala Lys Pro Asp Asp Leu Leu Ile Cys Thr Tyr Pro 
        35                  40                  45              


Lys Ala Gly Thr Thr Trp Ile Gln Glu Ile Val Asp Met Ile Glu Gln 
    50                  55                  60                  


Asn Gly Asp Val Glu Lys Cys Gln Arg Ala Ile Ile Gln His Arg His 
65                  70                  75                  80  


Pro Phe Ile Glu Trp Ala Arg Pro Pro Gln Pro Ser Val Leu Val Leu 
                85                  90                  95      


Arg Arg Cys Phe Leu Leu Ser Tyr Phe Lys Gly Val Glu Lys Ala Lys 
            100                 105                 110         


Ala Met Pro Ser Pro Arg Ile Leu Lys Thr His Leu Ser Thr Gln Leu 
        115                 120                 125             


Leu Pro Pro Ser Phe Trp Glu Asn Asn Cys Lys Phe Leu Tyr Val Ala 
    130                 135                 140                 


Arg Asn Ala Lys Asp Cys Met Val Ser Tyr Tyr His Phe Gln Arg Met 
145                 150                 155                 160 


Asn His Met Leu Pro Asp Pro Gly Thr Trp Glu Glu Tyr Phe Glu Thr 
                165                 170                 175     


Phe Ile Asn Gly Lys Val Val Trp Gly Ser Trp Phe Asp His Val Lys 
            180                 185                 190         


Gly Trp Trp Glu Met Lys Asp Arg His Gln Ile Leu Phe Leu Phe Tyr 
        195                 200                 205             


Glu Asp Ile Lys Arg Asp Pro Lys His Glu Ile Arg Lys Val Met Gln 
    210                 215                 220                 


Phe Met Gly Lys Lys Val Asp Glu Thr Val Leu Asp Lys Ile Val Gln 
225                 230                 235                 240 


Glu Thr Ser Phe Glu Lys Met Lys Glu Asn Pro Met Thr Asn Arg Ser 
                245                 250                 255     


Thr Val Ser Lys Ser Ile Leu Asp Gln Ser Ile Ser Ser Phe Met Arg 
            260                 265                 270         


Lys Gly Thr Val Gly Asp Trp Lys Asn His Phe Thr Val Ala Gln Asn 
        275                 280                 285             


Glu Arg Phe Asp Glu Ile Tyr Arg Arg Lys Met Glu Gly Thr Ser Ile 
    290                 295                 300                 


Asn Phe Cys Met Glu Leu 
305                 310 


<210>  8151
<211>  6378
<212>  DNA
<213>  Homosapiens

<400>  8151
tctcaagaaa gcctcttttt ctgcacccag aggcgaggca aggaaattac cttacctctc     60

tttggcagta ggtgatcttt ttctctctca cctttcactg aggtagcaga catttgagtt    120

tctccggcta atgcatgggt ctctgttcct aatctgtgcc tcactaaagt ccagggctac    180

cagcctcttc cctgagcaga ggtcactgaa ctgagcactg ggtgtccaga gggtgaaccc    240

actcagggca gctgtcatca aagcctttgc ccacttctcc atcttgcagc tccctccctc    300

ttcactttcg tccctggagg gtccccttat tttcttatga gcctgattat gcacttaaat    360

gatacgtttg gtgttttaat cagaatctgc aggtgtgtga ttaacaggaa agatcttcat    420

aatgttcagg ccaccatgtc tccagcagtg aaagtacttg gagagaccct tgaagagtga    480

gtgggactgt ccagatgtgt agaaatgaga gccggaggga gccacagggg cgtggggcag    540

caggaccagg gcatgtggaa ggtcagagtg tgagctggcg tagaggtgga gctgagaaaa    600

gagactagag gcaggagagc tttgcagttc ttctaaggaa tatggacttc aaaaatggtt    660

aaaggtggtt ttccaacttt tctttttagt accaaaacac ttttttattt aacaaaaatt    720

accatgacta catgatccag caattccact tctgggtata tatcccaaag aaataaaaac    780

agggtctgaa acagatacct gtacatctac attcaaaata acattattca caatagccaa    840

aaggtggcaa caacccaagt gtccaccaat ggctgaattg ataaacaaga tgtggatata    900

caatggaaca ttactcagtc ttaaagagga aggagatttt ctgcactaac ttgacccagc    960

tcctctgaca tgattcgcat gagcctctga ttcccacact agagtggaag ctccttaggg   1020

agaaggcctg tgtttttctt gtctttgttg ccttttcccc taacctcagc ttaacacgat   1080

gattgcacaa agtgctcgtt aaggctttta aatgagagag tagaggccgg gcaccgtggc   1140

tcatgtctgt aatcccagca ctttgggagg ccaaggcagg tggatcacga ggtcaccaga   1200

tcgagaccag cctgaccaac atggtgaaac cccgtctcta ctaaaaatag aaaaattaga   1260

tgggcgtggt ggccaagcgc ctgtaatccc agctactcgg gaggctgagg caggagaact   1320

gcttgaacct gggaagcgga ggttgcagtg agccgagatc gcaccactgc actccagcct   1380

ggtgatggac caagactccg tctcaaaaaa aaaatgagac agtagaaatc atgactcaca   1440

ggccagcaag tatacatgtt tttagagatg aaacaagtga ttgcaaacag gccgggtaca   1500

tgagacagcc tgctgcaggc acatgggggt catctctggc tggcaggaag gtgagggagt   1560

cctctcttct ctggtcctgg ctgactctgc ctcagcagga cttcacttga ccattctcac   1620

cttctgtcac ctcatcctta aagtgacaga gtaaattaac tctaaggccc catccaggac   1680

tcaagctgtg tgattttaca aaaatgaaaa ttatattaat aatcccattg taaaatccca   1740

aaagaaagtc aagagactag cagaaagaca ggtgggtgat gggatgtcct ggacagagcc   1800

tggatcatga ggtccccatg tagtgcttgt actacgcaga tgtttcctct tgagctattt   1860

taaaggtgtg gaaaaagcca aagcaatgcc ctctccacgg atactaaaga ctcacctttc   1920

cactcagctg ctgccaccgt ctttctggga aaacaactgc aaggtaagat accaacagct   1980

ccctgtgaca gaagggaaag taagccaacc aaagcgagtc ctgcagaccc caacgcagag   2040

cattcgtgat cacctttgcc tctccactgt ctctgatgct taccagcaaa gagaaaacat   2100

aaagttctac attcagcagg acattcacct gaacagtttc aaataggaca tgaaggcagg   2160

atccagattg aatgtttgga gggaactaga gacatgggga ggcagtgagt gcagtaagcg   2220

tagctgtgaa atgaagggga gaagatggtg gtcccaggct gcaggccatg gggaggtttt   2280

ctaacagacc agggagggaa gaatgagagg aaaaaagcta aagctctccc caaaggaggc   2340

caggcgcggt ggctcacgcc tgtaatccca gcactttggg aggccgaggc gggtggatca   2400

caaagtcagg agatcgagag cacggtgaaa ccccgtctct actaaaaata aaaaaaaact   2460

tagccgggcg cggtggcggg cgcctgtagt cccagctact cgggagggtg aggcaggaga   2520

atggcgtgaa cccgggaggc ggagcttgca gtgagccgag atcacgccac tgcactccag   2580

cctgggccac agagcgagac tccatctcaa aaaaaaagtt ctccccaaag ggtaaacaga   2640

tgaatcaggc agagcaacgc tcttgaggac accccacctc tgcctctggt agactctgag   2700

ttcttcgttt tatttattct gtgactttat tcgtatgcac cccagtgcct aataagttcc   2760

tggcacatag agggcattag acacgtcctt gctgagtaaa tacggaagtg gctgtagagc   2820

aggtggagtc aagggtacaa actgagccgc cagccttggt gagaaagtgg ggcactgctt   2880

ccttaaaggc aggaatgaag gggaaagaag ggctaagaaa gatatgttgc taggggactg   2940

gagtgaagtt ggaggactca aatgacttca ctccttttag taataatgtt ggataagggg   3000

acaaaaactt ccatttccag aattatggca aactaggtgt tctgaacccc tgaagccctt   3060

atatgtagaa catccaggat tactgcataa aaaaatcaca agtttccttt taatgcataa   3120

ctgagatcaa aataaagtcc ctaagtttag aaactgcaga ggaaactgaa actcagagag   3180

gcaaattgag actgggactc tccaggggaa atctgatgac ctggataatc cagcaattta   3240

agttttaatg gctgcacagg gacagggtca aagcccatgg cacaaggaac cagaagaatg   3300

aggagccaaa gctgggacca ctgaagggct acatcctcaa tggatgggtg gaggaggcag   3360

agaaagacct tagggaacca ctctgccttg acctaggcgc tcagctccct tgagaatgta   3420

tagccacagg tttactccct cggggtttga gattgaaaat tgcactcctt gcattgtcca   3480

agaaactaca agcagagaca ttccacaagg tggtccccac agccagtgtt cccaggtccg   3540

ctctggaggg acacagctgc aactcagacc cccataggat ccccacttga gctcaccatc   3600

ccacattaca aaatacacaa aagaacaagc caccatgaga tgcagtcttc agaaagaacc   3660

catggaagag tcagacctca agaacttcag acaatgtaat tatcaactct agaaataaga   3720

gaaggttcaa gttgtgtgaa taaatgaaaa agtgtatcaa aaataaaata aagaaataag   3780

atgctacttt tagacacaga aatattaagt aaataaatgg aatttctata acaaaaaaat   3840

ataaaatcat ggaaattaaa aactcaagca taggataaag tgcagaacag ctgcatagag   3900

aattagtgaa ctcagacagg aaggtttgag ggtaaaggtt tgaggagaga ggagagacct   3960

gtgtctggag ctaagagcca agagatggag cacgggaggg attaataaaa ggattatcaa   4020

gcagcaatga agaggaagaa aactgagcat aaaaaattta gaaactaggg gaatttttta   4080

aatcagcatt tcttaaaacc ttctttactg gtgcttggca gcttggtaag ttggagaaga   4140

gaagatgggg agtaggactt agtagacagt aacagagtca acgctttcag gagcagggtt   4200

tctcaacctt agcacttgct ctaaagggcc tgggacttga tataatcagg catggcaaga   4260

catgcaggta cagtggtgac tgtcataagg aagaagtgtg tcctcgcaga tacctagaac   4320

aggaggcatg gcatgtcaca cagagcctca cagggaagca atgggatagg tcaggaggaa   4380

gagacagtga gtagaagaca tgggcaagag ccttgatgtg gtttctttgg gaaggaatag   4440

ttgaggcaag gtaggcaggc ttgggattgg ccagtttgaa ccactggagc aggctttcag   4500

ccacaggggc ttggcctagt ggtctggtat ctgaccctgg ggtgtcaggg caggtgaata   4560

atggcccagt gtgtaaaagc ccaacagtgg aagtgttggg ggtataggct ctggggtgtt   4620

gtaggcagtt cctccagagt cagcaaagcc ccaggatgtc aaagcatcag atacagaata   4680

taaaagacat aattaataca gcactcctga catttggggc agatttttct ttcttgtggg   4740

tgggagcaag gggactcttc tatgtattgt agaatgttga acagcatact tggcccctgc   4800

atggatgcca gtagcaccac tactccaagc tgtgcaacca aaaatgtctc cagacattgc   4860

caaatgtccc ctagtggata caatcatccc atcatcccca attgagaacc acttaaaagt   4920

gaaagaataa aaaagcacag cattgaaata gctggtcata gatctgagat gcatagtcaa   4980

gaggcccatt tggcattgat gccattaaaa tgtgaactga gtactggata aaaggtcaga   5040

tttggtaaaa tgaaaggttg ggagagtgca gggatgtgaa attgtgggca aagtggaact   5100

tgaaggaatg tttgtagggg cagagctgaa atgattagag atggaaatca ttcaagccga   5160

ggaggccagg agaaaaatag gagctatttt cttgctgtgt ggctcaaact cttaaacatg   5220

aagcttctgt gcatctttgg gagggtgcgc gaggggtcat cagtttacgt tgatactgtg   5280

gaagtctcct attcaagtgg caggtcatag tttacagaaa aagattttgc tcctgatacc   5340

aaaggggcaa tcaggcaatc taatcctcac caatccctaa ttgattagct aattaaaagg   5400

actgagtttg aagtagagag cagacttggt gacaaagcag agacagaaag aagagggagg   5460

tcacaaggcc aagtcgcagg gccagcactg cagaactgag ccagagtgca cagcaaccct   5520

caggatggct ctgcctaagg gaactctgtg aaagtccact ttttatacca tcttttaccc   5580

acctcttttc ttaccccaaa gttcctttat gtagctcgaa atgccaaaga ctgtatggtt   5640

tcctactacc atttccaaag gatgaaccac atgcttcctg accctggtac ctgggaagag   5700

tattttgaaa ccttcatcaa tggaaaagtg gtttggggtt cctggtttga ccacgtgaaa   5760

ggatggtggg agatgaaaga cagacaccag attctcttcc tcttctatga ggacataaag   5820

agggacccaa agcatgaaat tcggaaggtg atgcagttca tgggaaagaa ggtggatgaa   5880

acagtgctag ataaaattgt ccaggagacg tcatttgaga aaatgaaaga aaatcccatg   5940

acaaatcgtt ctacagtttc caaatctatc ttggaccagt caatttcctc cttcatgaga   6000

aaaggaactg tgggggattg gaaaaaccac ttcactgttg cccagaatga gaggtttgat   6060

gaaatctata gaagaaagat ggaaggaacc tccataaact tctgcatgga actctgagca   6120

agatgtaaat aaaattaaaa ggtggatggc aagagtgcaa atactatctt caatccttca   6180

gtcccagcca gaagaatctc tgaaagcata ttgtgaatgt atacaatgta gtacaaacaa   6240

tctctgtgat gattaacagt atgtcaccac ttcatttttt aaaaaggatc acgtctaatg   6300

cccattttcc caactattct ttccaaagta agatataagg tagcttaata aactaagtaa   6360

aacgtatgac ttgagtac                                                 6378


<210>  8152
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  8152

Met Val Ser Tyr Tyr His Phe Gln Arg Met Asn His Met Leu Pro Asp 
1               5                   10                  15      


Pro Gly Thr Trp Glu Glu Tyr Phe Glu Thr Phe Ile Asn Gly Lys Val 
            20                  25                  30          


Val Trp Gly Ser Trp Phe Asp His Val Lys Gly Trp Trp Glu Met Lys 
        35                  40                  45              


Asp Arg His Gln Ile Leu Phe Leu Phe Tyr Glu Asp Ile Lys Arg Asp 
    50                  55                  60                  


Pro Lys His Glu Ile Arg Lys Val Met Gln Phe Met Gly Lys Lys Val 
65                  70                  75                  80  


Asp Glu Thr Val Leu Asp Lys Ile Val Gln Glu Thr Ser Phe Glu Lys 
                85                  90                  95      


Met Lys Glu Asn Pro Met Thr Asn Arg Ser Thr Val Ser Lys Ser Ile 
            100                 105                 110         


Leu Asp Gln Ser Ile Ser Ser Phe Met Arg Lys Gly Thr Val Gly Asp 
        115                 120                 125             


Trp Lys Asn His Phe Thr Val Ala Gln Asn Glu Arg Phe Asp Glu Ile 
    130                 135                 140                 


Tyr Arg Arg Lys Met Glu Gly Thr Ser Ile Asn Phe Cys Met Glu Leu 
145                 150                 155                 160 


<210>  8153
<211>  918
<212>  DNA
<213>  Homosapiens

<400>  8153
atgatggtaa agcacagtgt tttgcaactc gaccagttgt ccacaactca agcaaggagg     60

gaccaatcta acaagaacag agatgcaaga aatagaacta gccccaggaa attcagtatt    120

caagctaaga tgcaaagagc cctagcacac cctctcccca catatacctg caccataaaa    180

gaattttccc aagtgaatgg aatcattctt caaaagaaaa tgtgcgattt ctgggataag    240

atctggaact tccaagccaa gcctgatgac ctgctcattg cttcttaccc caaagcagaa    300

aaacaggacc aggtcagcca agcgtcccag aagccaaaca aggatgcact ttctgaggac    360

agacactgca gaagccagag cccagtccaa ggaagcccca gaatcaggaa ggagatcgca    420

gacaagacca tgaagagaaa caaattttac cctcaaatgc agcaaaggac cctgaaaact    480

catcttcctg tacaactact gcctccatcc ttctgggagg aaaactgtaa gataatctat    540

gtggcaagaa atgccaagga taacctggtg tcctactacc attttcaaag gatgagcaaa    600

gcactccctg acctttggga agctgggata agtactttga aacattcctg gcaggcaatg    660

gtacacaata aaccccatgc agagaaatgg aaacagactc tgaatgagcc atgtgtgaaa    720

gtgtataagc ttgatggctc aactgctgcc agccctagaa ttcaaagaga acggaagggc    780

tggaacggga cccagccagc agggtttgtg accgcctctg ctgtgacgtc acagcctggt    840

gaggaggggg ctgcagttcc tcaggaaact gccagtggac aaattcataa acaagagctc    900

cagttccctg gaacctga                                                  918


<210>  8154
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  8154

Met Met Val Lys His Ser Val Leu Gln Leu Asp Gln Leu Ser Thr Thr 
1               5                   10                  15      


Gln Ala Arg Arg Asp Gln Ser Asn Lys Asn Arg Asp Ala Arg Asn Arg 
            20                  25                  30          


Thr Ser Pro Arg Lys Phe Ser Ile Gln Ala Lys Met Gln Arg Ala Leu 
        35                  40                  45              


Ala His Pro Leu Pro Thr Tyr Thr Cys Thr Ile Lys Glu Phe Ser Gln 
    50                  55                  60                  


Val Asn Gly Ile Ile Leu Gln Lys Lys Met Cys Asp Phe Trp Asp Lys 
65                  70                  75                  80  


Ile Trp Asn Phe Gln Ala Lys Pro Asp Asp Leu Leu Ile Ala Ser Tyr 
                85                  90                  95      


Pro Lys Ala Glu Lys Gln Asp Gln Val Ser Gln Ala Ser Gln Lys Pro 
            100                 105                 110         


Asn Lys Asp Ala Leu Ser Glu Asp Arg His Cys Arg Ser Gln Ser Pro 
        115                 120                 125             


Val Gln Gly Ser Pro Arg Ile Arg Lys Glu Ile Ala Asp Lys Thr Met 
    130                 135                 140                 


Lys Arg Asn Lys Phe Tyr Pro Gln Met Gln Gln Arg Thr Leu Lys Thr 
145                 150                 155                 160 


His Leu Pro Val Gln Leu Leu Pro Pro Ser Phe Trp Glu Glu Asn Cys 
                165                 170                 175     


Lys Ile Ile Tyr Val Ala Arg Asn Ala Lys Asp Asn Leu Val Ser Tyr 
            180                 185                 190         


Tyr His Phe Gln Arg Met Ser Lys Ala Leu Pro Asp Leu Trp Glu Ala 
        195                 200                 205             


Gly Ile Ser Thr Leu Lys His Ser Trp Gln Ala Met Val His Asn Lys 
    210                 215                 220                 


Pro His Ala Glu Lys Trp Lys Gln Thr Leu Asn Glu Pro Cys Val Lys 
225                 230                 235                 240 


Val Tyr Lys Leu Asp Gly Ser Thr Ala Ala Ser Pro Arg Ile Gln Arg 
                245                 250                 255     


Glu Arg Lys Gly Trp Asn Gly Thr Gln Pro Ala Gly Phe Val Thr Ala 
            260                 265                 270         


Ser Ala Val Thr Ser Gln Pro Gly Glu Glu Gly Ala Ala Val Pro Gln 
        275                 280                 285             


Glu Thr Ala Ser Gly Gln Ile His Lys Gln Glu Leu Gln Phe Pro Gly 
    290                 295                 300                 


Thr 
305 


<210>  8155
<211>  1872
<212>  DNA
<213>  Homosapiens

<400>  8155
actttttact ttcccctgct ggtgcccaag accaccgtgg aaggaatggc taaaggataa     60

ggtggaggag acaagtgagt tagaatgggg cttgttaccc ccagaagaat tttcccaagt    120

gaatggaatc attcttcaaa agaaaatgtg cgatttctgg gataagatct ggaacttcca    180

agccaagcct gatgacctgc tcattgcttc ttaccccaaa gcaggaacca cttggacaca    240

ggaaattgta gatctgatac aaaatgatgg cgatattgag aaaagcaggc gcgcttccat    300

tcaacttcaa caccctttcc tggagtggat aagaatgaca cactgtggga ttgaccaggc    360

taacacaatg ccttccccaa ggaccctgaa aactcatctt cctgtacaac tactgcctcc    420

atccttctgg gaggaaaact gtaagtgtcc aagagggaga atctgagacc cactttcctg    480

aggtcatcca atcccctccc atcttatcag gggtatggta tggcagctgt ggcagaggga    540

tggaggagag gagacaccag agggaaaaaa aaaacgcaaa tcctgttcac ccaggaggtc    600

aacaatggaa ggaatacaga ggagaaagca ccaggagggt gtagcaggca taccccgaga    660

tgaagagggg tttgggcgaa gttggatgtg caaacaactc aaccccacca tgacatgaag    720

gaggccaccg tgtgagcaca gggcctggaa caatgggtgt aatgagttac tgccacgtca    780

gagaaattgg ttgctcctgt tgatatggtt tgactgtgtc cccacccaaa tctcatcttg    840

aattgtactt cccataatcc ccacatgttg tgggacgcac ccggtggcag gtaatggaat    900

catgggtggt tgcctccatg ctgttctcat catagtgagt tctcatggga tctgatggtt    960

ttctaagggg cttttcccct ttttctcagc acttcctttt gctgccatca tgtgaagaag   1020

gatatgtttg cttccctttc caccatgatt gtaaatttgc tgaggcctcc ccagccatgc   1080

ggaactgtga gtcagttaaa cctcttttct ttataaatca cccagtctca ggtatgtcct   1140

tataggagcc tgagaacaga ctaatacacc tgtcaatgcc aaaatgatat attttggtgg   1200

atttaaaatt agcaaagcca gcctgcccaa ccacaaacac ctccatctca ggcacatggt   1260

actgctttaa ataaatatca gtaggacatg aaaggttggg tctgaaaagt catcacctac   1320

ctaacttcct cagattccta ccttttttta tattaatctt gaagcttgct ctccctatct   1380

aattttgtat agatttagga atgttaaagt gtgtggatag gctgatgcta taggttgctt   1440

ctaggggagg aatctgccaa gagatactga cccctgaccc tagtcataga ctgttctcac   1500

ttcacggtaa gtcaataaaa tgatagcttt cctgtttgag ggatgcccaa attctttgca   1560

aaatctaatt acaagtctga ataggcagta aaatttgttc ttgctattta tataattgta   1620

aactttaact cagaaatgga cattataagc tgttctcaga gtatccaaag atcaggttgg   1680

caccaacagg tcccgagtaa gtcaggtttt cttcacccct ccctgtgtcc ctctggggac   1740

cgagcacgtc cagggagcaa ggagcagacc agtcagcaaa atgtaaaacc tgtcttaacc   1800

tggaaggtgg ggctgtctta tccacatttg gctccacctc tgagctaact tctgattaaa   1860

gctgatctaa gg                                                       1872


<210>  8156
<211>  106
<212>  PRT
<213>  Homosapiens

<400>  8156

Met Cys Asp Phe Trp Asp Lys Ile Trp Asn Phe Gln Ala Lys Pro Asp 
1               5                   10                  15      


Asp Leu Leu Ile Ala Ser Tyr Pro Lys Ala Gly Thr Thr Trp Thr Gln 
            20                  25                  30          


Glu Ile Val Asp Leu Ile Gln Asn Asp Gly Asp Ile Glu Lys Ser Arg 
        35                  40                  45              


Arg Ala Ser Ile Gln Leu Gln His Pro Phe Leu Glu Trp Ile Arg Met 
    50                  55                  60                  


Thr His Cys Gly Ile Asp Gln Ala Asn Thr Met Pro Ser Pro Arg Thr 
65                  70                  75                  80  


Leu Lys Thr His Leu Pro Val Gln Leu Leu Pro Pro Ser Phe Trp Glu 
                85                  90                  95      


Glu Asn Cys Lys Cys Pro Arg Gly Arg Ile 
            100                 105     


<210>  8157
<211>  1737
<212>  DNA
<213>  Homosapiens

<400>  8157
gtcacagcct ggtgaggagg gggctgcagt tcctcaggaa actgccagtg gacaaattca     60

taaacaagag ctccagttcc ctggaacctg agtcgggaga cctgcagctc actttctccc    120

tgtttgctgg ccagcagggt ttgtggccgc ctctgctgtg acgccacagc ctggtgagga    180

gggggctgca gttcctcagg aaactgccag tggacaaagt cataaacaag agttccagtt    240

ccctggaacc tgagtcggga ggcctgcaac tcactttctc cctgtttgct ggcccagaca    300

ggcctgtgct agagggctgg atagtgtggt agtgtggtgg atagagtgct gcctctatcc    360

acaacgcagc catatgctga ctgaagataa ctttgtgtct ggaagagccc tctgatttct    420

tacactaatg gccttacacg acatggagga ttttacattt gatggaacaa agcgcttaag    480

tgtcaactac gtgaagggaa ttcttcaacc gacagacacc tgtgacatct gggataagat    540

ctggaacttc caagccaagc ctgatgacct gcttatttct acctatccta aagcaggaac    600

aacatggact caggagatag tggaattaat acaaaatgaa ggtgatgtgg agaaaagtaa    660

acgggcaccg actcatcaac gatttccttt cctcgaaatg aaaatcccat ccttaggatc    720

tggtgagtat aaatagccac acttcactac agtcctaaaa tgcacttagg atttttactg    780

tctttgcacc tttcgaaatt ataggctttc aaacaattat tggtaagttt catggttttg    840

tcttttttta actgtgtctg gccattgtta tactccagac attttctaat ggaattactg    900

tttgtacaaa agtgagttaa attttgtttc tctagttaga aattaatttt acttcaaaag    960

aataagctca agtaagataa tcctggtgaa agggtttgaa ttttttaggt tcttatttat   1020

ttggatgact gttatggtta ggaattgttc tagtcaaaac atctattcat aggctagacg   1080

tattctctca caccagatct acagttacaa tgttcttata gatgctttga attgtagtag   1140

taataatgga agcagcaaga cttggaagca aatagataaa aaaaaaatcg tagaaattga   1200

tcgaaaacca gttttgcagg tttggaacaa gctcatgcaa tgccctcacc acggatcctg   1260

aaaacacatc ttccctttca cttgctgcca ccatccttgc tagagaaaaa ctgtaaggta   1320

aaaaagcaaa aggaattcag agttgtactc cttaaaacaa ccttagtctt ccatttcctc   1380

ttaaaacact tcacttgtta aatatatata tatatacctc ttcacaataa tcaatatgca   1440

aattaatatg aatcctagcc aggcacgttg gctcatgcct gtaatcacag cattttggga   1500

gactgagatg ggtggatcag ttgaggtcag gggttcaaga ccagcctgac caacacggcg   1560

aaaccccatc tctaccaaaa acacaaaatt cacaggacgt ggtgacacat gcctgtaatc   1620

caagctactc aggaggctga ggcaggagac tcgcttgaac acaggaggca gaggttgcag   1680

tgagccaaga tagtgccatt gcactccagc ctgggtgaca gagcaagact ccatctc      1737


<210>  8158
<211>  102
<212>  PRT
<213>  Homosapiens

<400>  8158

Met Ala Leu His Asp Met Glu Asp Phe Thr Phe Asp Gly Thr Lys Arg 
1               5                   10                  15      


Leu Ser Val Asn Tyr Val Lys Gly Ile Leu Gln Pro Thr Asp Thr Cys 
            20                  25                  30          


Asp Ile Trp Asp Lys Ile Trp Asn Phe Gln Ala Lys Pro Asp Asp Leu 
        35                  40                  45              


Leu Ile Ser Thr Tyr Pro Lys Ala Gly Thr Thr Trp Thr Gln Glu Ile 
    50                  55                  60                  


Val Glu Leu Ile Gln Asn Glu Gly Asp Val Glu Lys Ser Lys Arg Ala 
65                  70                  75                  80  


Pro Thr His Gln Arg Phe Pro Phe Leu Glu Met Lys Ile Pro Ser Leu 
                85                  90                  95      


Gly Ser Gly Glu Tyr Lys 
            100         


<210>  8159
<211>  1664
<212>  DNA
<213>  Homosapiens

<400>  8159
aattcataaa caagagctcc agttccctgg aacctgagtc gggagacctg cagctcactt     60

tctccctgtt tgctggccag cagggtttgt ggccgcctct gctgtgacgc cacagcctgg    120

tgaggagggg gctgcagttc ctcaggaaac tgccagtgga caaagtcata aacaagagtt    180

ccagttccct ggaacctgag tcgggaggcc tgcaactcac tttctccctg tttgctggcc    240

cagacaggcc tgtgctagag ggctggatag tgtggtagtg tggtggatag agtgctgcct    300

ctatccacaa cgcagccata tgctgactga agataacttt gtgtctggaa gagccctctg    360

atttcttaca ctaatggcct tacacgacat ggaggatttt acatttgatg gaacaaagcg    420

cttaagtgtc aactacgtga agggaattct tcaaccgaca gacacctgtg acatctggga    480

taagatctgg aacttccaag ccaagcctga tgacctgctt atttctacct atcctaaagc    540

aggaacaaca tggactcagg agatagtgga attaatacaa aatgaaggtg atgtggagaa    600

aagtaaacgg gcaccgactc atcaacgatt tcctttcctc gaaatgaaaa tcccatcctt    660

aggatctggt ttggaacaag ctcatgcaat gccctcacca cggatcctga aaacacatct    720

tccctttcac ttgctgccac catccttgct agagaaaaac tgtaagataa tctatgtagc    780

aagaaatccc aaggacaaca tggtgtccta ttaccatttc caaagaatga ataaagctct    840

tcctgctcca ggaacatggg aagagtattt tgagactttt ctggctggga aagtgtgctg    900

gggctcctgg catgaacatg tgaaaggatg gtgggaagcc aaagacaaac accgtattct    960

ctatctcttc tatgaggaca tgaagaagaa cccaaagcat gaaattcaga agctggcaga   1020

atttattggg aagaaattag atgacaaagt tctagataaa attgtccatt acacttcgtt   1080

tgatgtcatg aaacagaatc caatggcaaa ctattcatcg attcctgctg aaatcatgga   1140

ccactccatt tctccattca tgagaaaagg ggcagtggga gactggaaga aacacttcac   1200

cgtggctcag aatgagagat ttgatgaaga ttacaagaag aaaatgactg ataccagact   1260

aactttccac ttccagttct agtaaggaag aaaaactgaa aatgttttag tttattaccc   1320

agtatatttg ggtaataatg aaagtttaat tctcataaca aatgatatca gattccagtt   1380

atcagaatag tttactgtgt ttgctcttat tcactctact aaaaaattat tttaaaaggc   1440

tggaggcaag gtggtgacag gcagcagggt ggcgacatgg agagagggaa gctcaataaa   1500

tcactaggta caatcctggt atcattgcca attatcatca tatttacatt ttctacaatc   1560

atgtgcttat taacatattg gaaatgcttc agtcctcaca tgataataca ctaacatttt   1620

cagattaagt tttggttcaa gttaattttt tttttttttt tttt                    1664


<210>  8160
<211>  302
<212>  PRT
<213>  Homosapiens

<400>  8160

Met Ala Leu His Asp Met Glu Asp Phe Thr Phe Asp Gly Thr Lys Arg 
1               5                   10                  15      


Leu Ser Val Asn Tyr Val Lys Gly Ile Leu Gln Pro Thr Asp Thr Cys 
            20                  25                  30          


Asp Ile Trp Asp Lys Ile Trp Asn Phe Gln Ala Lys Pro Asp Asp Leu 
        35                  40                  45              


Leu Ile Ser Thr Tyr Pro Lys Ala Gly Thr Thr Trp Thr Gln Glu Ile 
    50                  55                  60                  


Val Glu Leu Ile Gln Asn Glu Gly Asp Val Glu Lys Ser Lys Arg Ala 
65                  70                  75                  80  


Pro Thr His Gln Arg Phe Pro Phe Leu Glu Met Lys Ile Pro Ser Leu 
                85                  90                  95      


Gly Ser Gly Leu Glu Gln Ala His Ala Met Pro Ser Pro Arg Ile Leu 
            100                 105                 110         


Lys Thr His Leu Pro Phe His Leu Leu Pro Pro Ser Leu Leu Glu Lys 
        115                 120                 125             


Asn Cys Lys Ile Ile Tyr Val Ala Arg Asn Pro Lys Asp Asn Met Val 
    130                 135                 140                 


Ser Tyr Tyr His Phe Gln Arg Met Asn Lys Ala Leu Pro Ala Pro Gly 
145                 150                 155                 160 


Thr Trp Glu Glu Tyr Phe Glu Thr Phe Leu Ala Gly Lys Val Cys Trp 
                165                 170                 175     


Gly Ser Trp His Glu His Val Lys Gly Trp Trp Glu Ala Lys Asp Lys 
            180                 185                 190         


His Arg Ile Leu Tyr Leu Phe Tyr Glu Asp Met Lys Lys Asn Pro Lys 
        195                 200                 205             


His Glu Ile Gln Lys Leu Ala Glu Phe Ile Gly Lys Lys Leu Asp Asp 
    210                 215                 220                 


Lys Val Leu Asp Lys Ile Val His Tyr Thr Ser Phe Asp Val Met Lys 
225                 230                 235                 240 


Gln Asn Pro Met Ala Asn Tyr Ser Ser Ile Pro Ala Glu Ile Met Asp 
                245                 250                 255     


His Ser Ile Ser Pro Phe Met Arg Lys Gly Ala Val Gly Asp Trp Lys 
            260                 265                 270         


Lys His Phe Thr Val Ala Gln Asn Glu Arg Phe Asp Glu Asp Tyr Lys 
        275                 280                 285             


Lys Lys Met Thr Asp Thr Arg Leu Thr Phe His Phe Gln Phe 
    290                 295                 300         


<210>  8161
<211>  804
<212>  DNA
<213>  Homosapiens

<400>  8161
gcaccgactc atcaacgatt tcctttcctc gaaatgaaaa tcccatcctt aggatctgtg     60

tgctggggct cctggcatga acatgtgaaa ggatggtggg aagccaaaga caaacaccgt    120

attctctatc tcttctatga ggacatgaag aagaacccaa agcatgaaat tcagaagctg    180

gcagaattta ttgggaagaa attagatgac aaagttctag ataaaattgt ccattacact    240

tcgtttgatg tcatgaaaca gaatccaatg gcaaactatt catcgattcc tgctgaaatc    300

atggaccact ccatttctcc attcatgaga aaaggggcag tgggagactg gaagaaacac    360

ttcaccgtgg ctcagaatga gagatttgat gaagattaca agaagaaaat gactgatacc    420

agactaactt tccacttcca gttctagtaa ggaagaaaaa ctgaaaatgt tttagtttat    480

tacccagtat atttgggtaa taatgaaagt ttaattctca taacaaatga tatcagattc    540

cagttatcag aatagtttac tgtgtttgct cttattcact ctactaaaaa attattttaa    600

aaggctggag gcaaggtggt gacaggcagc agggtggcga catggagaga gggaagctca    660

ataaatcact aggtacaatc ctggtatcat tgccaattat catcatattt acattttcta    720

caatcatgtg cttattaaca tattggaaat gcttcagtcc tcacatgata atacactaac    780

attttcagat taagttttgg ttca                                           804


<210>  8162
<211>  137
<212>  PRT
<213>  Homosapiens

<400>  8162

Met Lys Ile Pro Ser Leu Gly Ser Val Cys Trp Gly Ser Trp His Glu 
1               5                   10                  15      


His Val Lys Gly Trp Trp Glu Ala Lys Asp Lys His Arg Ile Leu Tyr 
            20                  25                  30          


Leu Phe Tyr Glu Asp Met Lys Lys Asn Pro Lys His Glu Ile Gln Lys 
        35                  40                  45              


Leu Ala Glu Phe Ile Gly Lys Lys Leu Asp Asp Lys Val Leu Asp Lys 
    50                  55                  60                  


Ile Val His Tyr Thr Ser Phe Asp Val Met Lys Gln Asn Pro Met Ala 
65                  70                  75                  80  


Asn Tyr Ser Ser Ile Pro Ala Glu Ile Met Asp His Ser Ile Ser Pro 
                85                  90                  95      


Phe Met Arg Lys Gly Ala Val Gly Asp Trp Lys Lys His Phe Thr Val 
            100                 105                 110         


Ala Gln Asn Glu Arg Phe Asp Glu Asp Tyr Lys Lys Lys Met Thr Asp 
        115                 120                 125             


Thr Arg Leu Thr Phe His Phe Gln Phe 
    130                 135         


<210>  8163
<211>  7539
<212>  DNA
<213>  Homosapiens

<400>  8163
ccttcgggaa agggtggcct cgggccccct actctacaga gtctcctccc acggctgccc     60

agttccctgg ccgactatct tgcctccacc acatcaccat cagtaccggg cggctgcagg    120

gcagagctgt ccagggacct cctcacagcc tccagagtca agaaatgcct cctcagggaa    180

gccctctacc gcatccctga cctgtgagtc acggagctcc cgggcaccat gctggccaca    240

aatgcctaag gagccccccg gaaccagctg tgggtcccgc aggcactcgc aggctagcgg    300

acacctttgg aggactgaga gacctgtcct gcaatccaat gttcctcact ctcacaagat    360

tttacagacg tggaaaccga ggcccgaggc cccaaggggt aatcggcccg ccttcccatg    420

ccaataaccg gcagtggcgg gacccacacc tactccgtga cctgcaggcc caggggtcga    480

gccccaggta gaacgtctag acggactccg cccttagcgc cgtacgggga accttctccc    540

ggacgcagac acggaagcgg aagtgctgcc gagctgtagc tatggagacg tggggggcgg    600

gccgcccgga gagcgcgacc tttgacctgc agtagagcct acgtcagagg ctggcgcaaa    660

cagaagtgca gcggtggcgg cggctggttg cgggccggcg gcgggctggc ggagatggag    720

gatcttgttc aagatggggt ggcttcacca gctacccctg ggaccgggaa atctaagctg    780

gaaacattgc ccaaagaaga cctcatcaag tttgccaaga aacagatgat gctaatacag    840

aaagctaaat caaggtgtac agaattggag aaagaaattg aagaactcag atcaaaacct    900

gttactgaag gaactggtga tattattaag gcattaactg aacgtctgga tgctcttctt    960

ctggaaaaag cagagactga gcaacagtgt ctttctctga aaaaggaaaa tataaaaatg   1020

aagcaagagg ttgaggattc tgtaacaaag atgggagatg cacataagga gttggaacaa   1080

tcacatataa actatgtgaa agaaattgaa aatttgaaaa atgagttgat ggcagtacgt   1140

tccaaataca gtgaagacaa agctaactta caaaagcagc tggaagaagc aatgaatacg   1200

caattagaac tttcagaaca acttaaattt cagaacaact ctgaagataa tgttaaaaaa   1260

ctacaagaag agattgagaa aattaggcca ggctttgagg agcaaatttt atatctgcaa   1320

aagcaattag acgctaccac tgatgaaaag aaggaaacag ttactcaact ccaaaatatc   1380

attgaggcta attctcagca ttaccaaaaa aatattaata gtttgcagga agagctttta   1440

cagttgaaag ctatacacca agaagaggtg aaagagttga tgtgccagat tgaagcatca   1500

gctaaggaac atgaagcaga gataaataag ttgaacgagc taaaagagaa cttagtaaaa   1560

caatgtgagg caagtgaaaa gaacatccag aagaaatatg aatgtgagtt agaaaattta   1620

aggaaagcca cctcaaatgc aaaccaagac aatcagatat gttctattct cttgcaagaa   1680

aatacatttg tagaacaagt agtaaatgaa aaagtcaaac acttagaaga taccttaaaa   1740

gaacttgaat ctcaacacag tatcttaaaa gatgaggtaa cttatatgaa taatcttaag   1800

ttaaaacttg aaatggatgc tcaacatata aaggatgagt tttttcatga acgggaagac   1860

ttagagttta aaattaatga attattacta gctaaagaag aacagggctg tgtaattgaa   1920

aaattaaaat ctgagctagc aggtttaaat aaacagtttt gctatactgt agaacagcat   1980

aacagagaag tacagagtct taaggaacaa catcaaaaag aaatatcaga actaaatgag   2040

acatttttgt cagattcaga aaaagaaaaa ttaacattaa tgtttgaaat acagggtctt   2100

aaggaacagt gtgaaaacct acagcaagaa aagcaagaag caattttaaa ttatgagagt   2160

ttacgagaga ttatggaaat tttacaaaca gaactggggg aatctgctgg aaaaataagt   2220

caagagttcg aatcaatgaa gcaacagcaa gcatctgatg ttcatgaact gcagcagaag   2280

ctcagaactg cttttactga aaaagatgcc cttctcgaaa ctgtgaatcg cctccaggga   2340

gaaaatgaaa agttactatc tcaacaagaa ttggtaccag aacttgaaaa taccataaag   2400

aaccttcaag aaaagaatgg agtatactta cttagtctca gtcaaagaga taccatgtta   2460

aaagaattag aaggaaagat aaattctctt actgaggaaa aagatgattt tataaataaa   2520

ctgaaaaatt cccatgaaga aatggataat ttccataaga aatgtgaaag ggaagaaaga   2580

ttgattcttg aacttgggaa gaaagtagag caaacaatcc agtacaacag tgaactagaa   2640

caaaaggtaa atgaattaac aggaggacta gaggagactt taaaagaaaa ggatcaaaat   2700

gaccaaaaac tagaaaaact tatggttcaa atgaaagttc tctctgaaga caaagaagta   2760

ttgtcagctg aagtgaagtc tctttatgag gaaaacaata aactcagttc agaaaaaaaa   2820

cagttgagta gggatttgga ggtttttttg tctcaaaaag aagatgttat ccttaaagaa   2880

catattactc aattagaaaa gaaacttcag ttaatggttg aagagcaaga taatttaaat   2940

aaactgcttg aaaatgagca agttcagaag ttatttgtta aaactcagtt gtatggtttt   3000

cttaaagaaa tgggatcaga agtttcagaa gacagtgaag agaaagatgt tgttaatgtc   3060

ctacaggcag tcggtgaatc cttggcaaaa ataaatgagg aaaaatgcaa cctggctttt   3120

cagcgtgatg aaaaagtatt agagttagaa aaagagatta agtgccttca agaagagagt   3180

gtagttcagt gtgaagaact taagtcttta ttgagagact atgagcaaga gaaagttctc   3240

ttaaggaaag agttagaaga aatacagtca gaaaaagagg ccctgcagtc tgatcttcta   3300

gaaatgaaga atgctaatga aaaaacaagg cttgaaaatc agaatctttt aattcaagtt   3360

gaagaagtat ctcaaacatg tagcaaaagt gaaatccata atgaaaaaga aaaatgtttt   3420

ataaaggaac atgaaaacct aaagccacta ctagaacaaa aagaattacg agataggaga   3480

gcagagttga tactattaaa ggattcctta gcaaaatcac cttctgtaaa aaatgatcct   3540

ctgtcttcag taaaagagtt ggaagaaaaa atagaaaatc tggaaaaaga atgcaaagaa   3600

aaggaggaga aaataaataa gataaaatta gttgccgtaa aggcaaagaa agaactagat   3660

tccagcagaa aagagaccca gactgtgaag gaagaacttg aatctcttcg atcagaaaag   3720

gaccagttat ctgcttccat gagagatctc attcaaggag cagaaagcta taagaatctt   3780

ttattagaat atgaaaagca gtcagagcaa ctggatgtgg aaaaagaacg tgctaataat   3840

tttgagcatc gtattgaaga ccttacaaga caattaagaa attcgacttt gcagtgtgaa   3900

acaataaatt ctgataatga agatctcctg gctcgtattg agacattaca gtctaatgcc   3960

aaattattag aagtacagat tttagaagtc cagagagcca aagcaatggt agacaaagaa   4020

ttagaagctg aaaaacttca gaaagaacag aagataaagg aacatgccac tactgtaaat   4080

gaacttgaag aacttcaggt acaacttcaa aagcaaaaga aacagcttca gaaaaccatg   4140

caagaattag agctggttaa aaaggatgcc caacaaacca cattgatgaa tatggaaata   4200

gctgattatg aacgtttgat gaaagaacta aatcaaaagt taactaataa aaacaacaag   4260

atagaagatt tggagcaaga aataaaaatt caaaaacaga aacaagaaac cctacaagaa   4320

gaaataactt cattacagtc ttcagtacaa caatatgaag aaaaaaacac caaaatcaag   4380

caattgcttg tgaaaaccaa aaaggaactg gcagattcaa agcaagcaga aactgatcac   4440

ttaatacttc aagcatcttt aaaaggtgag ctggaggcaa gccagcagca agtagaagtc   4500

tataaaatac agctggctga aataacatca gagaagcaca aaatccacga gcacctgaaa   4560

acctctgcgg aacagcacca gcgtacgcta agtgcatacc agcagagagt gacagcacta   4620

caggaagagt gccgtgctgc caaggcagaa caagctactg taacctctga attcgagagc   4680

tacaaagtcc gagttcataa tgttctaaaa caacagaaaa ataaatctat gtctcaggct   4740

gaaactgagg gcgctaaaca agaaagggaa catctggaaa tgctgattga ccagctaaaa   4800

atcaaattac aagatagcca aaataactta cagattaatg tatctgaact tcaaacattg   4860

cagtctgaac atgatacact gctagaaagg cacaacaaga tgctgcagga aactgtgtcc   4920

aaagaggcgg aactccggga aaaattgtgt tcaatacagt cagagaacat gatgatgaaa   4980

tctgaacata cacagactgt gagtcagcta acatcccaga acgaggtcct tcgaaatagc   5040

ttccgagatc aagtgcgaca tttgcaggaa gaacacagaa agacagtgga gacattacag   5100

cagcagctct ccaagatgga agcacagctc ttccagctta agaatgaacc gaccacaaga   5160

agcccagttt cctctcaaca atctttgaag aaccttcgag aaaggagaaa cacagacctc   5220

ccgcttctag acatgcacac tgtaacccgg gaagagggag aaggcatgga gacaactgat   5280

acggagtctg tgtcttccgc cagcacatac acacagtctt tagagcagct gcttaactct   5340

cccgaaacta aacttgagcc tccattatgg catgctgaat ttaccaaaga agaattggtt   5400

cagaagctca gttccaccac aaaaagtgca gatcacttaa acggcctgct tcgggaaaca   5460

gaagcaacca atgcaattct tatggagcaa attaagcttc tcaaaagtga aataagaaga   5520

ttggaaagga atcaagagcg agagaagtct gcagctaacc tggaatactt gaagaacgtc   5580

ttgctgcagt tcattttctt gaaaccaggt agtgaaagag agagacttct tcctgttata   5640

aatacgatgt tgcagctcag ccctgaagaa aagggaaaac ttgctgcggt tgctcaaggt   5700

gaggaagaaa atgcttcccg ttcttctgga tgggcatcct atcttcatag ttggtctgga   5760

cttcgatagg ttgatggaag gaatattttt attaaccaaa tagaatctat ttacaaaaat   5820

ggttcacgta tattaccaca attcttttgt caaaaagtgt gtatatatgt ttgcatctac   5880

atatatttgt acatctatat gacagatgta ttttaaaagt ttcatcttga agtaaaagta   5940

caacagcttg aagtgttgat agcaggccac agccctctaa ctcatgtgat ttcccatgca   6000

tgctgccaga ataaaaccac caggaatgaa ttcactcccc acttctctgg aacctcagga   6060

cccgcccatt tctcggcagt actgtgaatt ttgaagttaa actaaatttt ggtaccatac   6120

caactggaat ttaggcttta aaaataatgt ttcaaggcca ggtgtggtga ttcatgcctg   6180

aaatcccact actttgggag gctgaggctg gagaattgct tgaggctagt gagctgtgac   6240

tcccactgca ctccagctcg gggaacagag cgagaccttg tctctaaaaa taatagtaat   6300

aaaataaaaa taacgtttta tgactattta ttgcaaggtc agagttacag attgttataa   6360

attgttgaga aatttttgtg attagaatat gaaggaaaaa gctttgttgg taaaagtgac   6420

atgttaaggg gctatgaagt aaatatgctg cagttaatta tgctaagtta aaatacagtt   6480

tagttatttg ctttaaaata aactcttctt tttttcttta aagtatacta tctcaaaact   6540

cattatgttg tcagagccct agagctggct agtgtaacac tgactatgag taggtgggcc   6600

cacacttgag ttgaggtgat ttcatggtgt ctttccaggc tcttgatagg gtgtcactgc   6660

atgcaagcca tgaatctgtt ttgagaatcc tctccatttt cccaaataaa aacctatcac   6720

aacagtgact atatcactca gcattggatc taaatataaa agtggtgctt tcagtgtttt   6780

tggcagatag tgttccataa gctttccatc agaagggatt ttagacacct tagaggtccg   6840

tgctacatcg tcacagttcc tccgaataac cttaggtggt agtgttactt gcctttgaca   6900

cctctgcata tgttttaatg actagatcca aactgtgttg ttcttaaatc aaaaattgga   6960

taatttgtaa tatttatgtg ttaatcacac agtatgctct ctgaagttct cttaagcctt   7020

cagtttatac tcttaattta attttctttc tgagctggag aactggcttt gcactttggt   7080

tacacagaac attggtttcc aattcagttt aactgaaatt tgctgctgat atgttgagtt   7140

tgttctttaa aaaatagctc atatatctca tctttcctcc tgtcttagaa gaacagacct   7200

aactagtgaa tgtattaatg aaaatgcatc tatttcagag ctgacatgaa gagtttagtt   7260

tttttacttt ataaactgtg aatatgagta tgccagctgc atacgatgta actaatcata   7320

tttaaatata tttcactttc tctttgactt tagacctttt gaagtctgta taaacttgtt   7380

ttgaaatata gtctctgctt acgaatgtca taacaaaata attttttgca tgataaaaaa   7440

ttactttgat tacaaaaggc atattctttc atggtttctg caatgagagg aagtgtaatg   7500

attattttaa tatttctatt aaatatgttt aactgtata                          7539


<210>  8164
<211>  1684
<212>  PRT
<213>  Homosapiens

<400>  8164

Met Glu Asp Leu Val Gln Asp Gly Val Ala Ser Pro Ala Thr Pro Gly 
1               5                   10                  15      


Thr Gly Lys Ser Lys Leu Glu Thr Leu Pro Lys Glu Asp Leu Ile Lys 
            20                  25                  30          


Phe Ala Lys Lys Gln Met Met Leu Ile Gln Lys Ala Lys Ser Arg Cys 
        35                  40                  45              


Thr Glu Leu Glu Lys Glu Ile Glu Glu Leu Arg Ser Lys Pro Val Thr 
    50                  55                  60                  


Glu Gly Thr Gly Asp Ile Ile Lys Ala Leu Thr Glu Arg Leu Asp Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Ala Glu Thr Glu Gln Gln Cys Leu Ser Leu Lys 
                85                  90                  95      


Lys Glu Asn Ile Lys Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys 
            100                 105                 110         


Met Gly Asp Ala His Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val 
        115                 120                 125             


Lys Glu Ile Glu Asn Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys 
    130                 135                 140                 


Tyr Ser Glu Asp Lys Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met 
145                 150                 155                 160 


Asn Thr Gln Leu Glu Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser 
                165                 170                 175     


Glu Asp Asn Val Lys Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro 
            180                 185                 190         


Gly Phe Glu Glu Gln Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr 
        195                 200                 205             


Thr Asp Glu Lys Lys Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu 
    210                 215                 220                 


Ala Asn Ser Gln His Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu 
225                 230                 235                 240 


Leu Leu Gln Leu Lys Ala Ile His Gln Glu Glu Val Lys Glu Leu Met 
                245                 250                 255     


Cys Gln Ile Glu Ala Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys 
            260                 265                 270         


Leu Asn Glu Leu Lys Glu Asn Leu Val Lys Gln Cys Glu Ala Ser Glu 
        275                 280                 285             


Lys Asn Ile Gln Lys Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys 
    290                 295                 300                 


Ala Thr Ser Asn Ala Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu 
305                 310                 315                 320 


Gln Glu Asn Thr Phe Val Glu Gln Val Val Asn Glu Lys Val Lys His 
                325                 330                 335     


Leu Glu Asp Thr Leu Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys 
            340                 345                 350         


Asp Glu Val Thr Tyr Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp 
        355                 360                 365             


Ala Gln His Ile Lys Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu 
    370                 375                 380                 


Phe Lys Ile Asn Glu Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val 
385                 390                 395                 400 


Ile Glu Lys Leu Lys Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys 
                405                 410                 415     


Tyr Thr Val Glu Gln His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln 
            420                 425                 430         


His Gln Lys Glu Ile Ser Glu Leu Asn Glu Thr Phe Leu Ser Asp Ser 
        435                 440                 445             


Glu Lys Glu Lys Leu Thr Leu Met Phe Glu Ile Gln Gly Leu Lys Glu 
    450                 455                 460                 


Gln Cys Glu Asn Leu Gln Gln Glu Lys Gln Glu Ala Ile Leu Asn Tyr 
465                 470                 475                 480 


Glu Ser Leu Arg Glu Ile Met Glu Ile Leu Gln Thr Glu Leu Gly Glu 
                485                 490                 495     


Ser Ala Gly Lys Ile Ser Gln Glu Phe Glu Ser Met Lys Gln Gln Gln 
            500                 505                 510         


Ala Ser Asp Val His Glu Leu Gln Gln Lys Leu Arg Thr Ala Phe Thr 
        515                 520                 525             


Glu Lys Asp Ala Leu Leu Glu Thr Val Asn Arg Leu Gln Gly Glu Asn 
    530                 535                 540                 


Glu Lys Leu Leu Ser Gln Gln Glu Leu Val Pro Glu Leu Glu Asn Thr 
545                 550                 555                 560 


Ile Lys Asn Leu Gln Glu Lys Asn Gly Val Tyr Leu Leu Ser Leu Ser 
                565                 570                 575     


Gln Arg Asp Thr Met Leu Lys Glu Leu Glu Gly Lys Ile Asn Ser Leu 
            580                 585                 590         


Thr Glu Glu Lys Asp Asp Phe Ile Asn Lys Leu Lys Asn Ser His Glu 
        595                 600                 605             


Glu Met Asp Asn Phe His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile 
    610                 615                 620                 


Leu Glu Leu Gly Lys Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu 
625                 630                 635                 640 


Leu Glu Gln Lys Val Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu 
                645                 650                 655     


Lys Glu Lys Asp Gln Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln 
            660                 665                 670         


Met Lys Val Leu Ser Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys 
        675                 680                 685             


Ser Leu Tyr Glu Glu Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu 
    690                 695                 700                 


Ser Arg Asp Leu Glu Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu 
705                 710                 715                 720 


Lys Glu His Ile Thr Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu 
                725                 730                 735     


Glu Gln Asp Asn Leu Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys 
            740                 745                 750         


Leu Phe Val Lys Thr Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser 
        755                 760                 765             


Glu Val Ser Glu Asp Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln 
    770                 775                 780                 


Ala Val Gly Glu Ser Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu 
785                 790                 795                 800 


Ala Phe Gln Arg Asp Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys 
                805                 810                 815     


Cys Leu Gln Glu Glu Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu 
            820                 825                 830         


Leu Arg Asp Tyr Glu Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu 
        835                 840                 845             


Glu Ile Gln Ser Glu Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met 
    850                 855                 860                 


Lys Asn Ala Asn Glu Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile 
865                 870                 875                 880 


Gln Val Glu Glu Val Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn 
                885                 890                 895     


Glu Lys Glu Lys Cys Phe Ile Lys Glu His Glu Asn Leu Lys Pro Leu 
            900                 905                 910         


Leu Glu Gln Lys Glu Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu 
        915                 920                 925             


Lys Asp Ser Leu Ala Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser 
    930                 935                 940                 


Ser Val Lys Glu Leu Glu Glu Lys Ile Glu Asn Leu Glu Lys Glu Cys 
945                 950                 955                 960 


Lys Glu Lys Glu Glu Lys Ile Asn Lys Ile Lys Leu Val Ala Val Lys 
                965                 970                 975     


Ala Lys Lys Glu Leu Asp Ser Ser Arg Lys Glu Thr Gln Thr Val Lys 
            980                 985                 990         


Glu Glu Leu Glu Ser Leu Arg Ser  Glu Lys Asp Gln Leu  Ser Ala Ser 
        995                 1000                 1005             


Met Arg  Asp Leu Ile Gln Gly  Ala Glu Ser Tyr Lys  Asn Leu Leu 
    1010                 1015                 1020             


Leu Glu  Tyr Glu Lys Gln Ser  Glu Gln Leu Asp Val  Glu Lys Glu 
    1025                 1030                 1035             


Arg Ala  Asn Asn Phe Glu His  Arg Ile Glu Asp Leu  Thr Arg Gln 
    1040                 1045                 1050             


Leu Arg  Asn Ser Thr Leu Gln  Cys Glu Thr Ile Asn  Ser Asp Asn 
    1055                 1060                 1065             


Glu Asp  Leu Leu Ala Arg Ile  Glu Thr Leu Gln Ser  Asn Ala Lys 
    1070                 1075                 1080             


Leu Leu  Glu Val Gln Ile Leu  Glu Val Gln Arg Ala  Lys Ala Met 
    1085                 1090                 1095             


Val Asp  Lys Glu Leu Glu Ala  Glu Lys Leu Gln Lys  Glu Gln Lys 
    1100                 1105                 1110             


Ile Lys  Glu His Ala Thr Thr  Val Asn Glu Leu Glu  Glu Leu Gln 
    1115                 1120                 1125             


Val Gln  Leu Gln Lys Gln Lys  Lys Gln Leu Gln Lys  Thr Met Gln 
    1130                 1135                 1140             


Glu Leu  Glu Leu Val Lys Lys  Asp Ala Gln Gln Thr  Thr Leu Met 
    1145                 1150                 1155             


Asn Met  Glu Ile Ala Asp Tyr  Glu Arg Leu Met Lys  Glu Leu Asn 
    1160                 1165                 1170             


Gln Lys  Leu Thr Asn Lys Asn  Asn Lys Ile Glu Asp  Leu Glu Gln 
    1175                 1180                 1185             


Glu Ile  Lys Ile Gln Lys Gln  Lys Gln Glu Thr Leu  Gln Glu Glu 
    1190                 1195                 1200             


Ile Thr  Ser Leu Gln Ser Ser  Val Gln Gln Tyr Glu  Glu Lys Asn 
    1205                 1210                 1215             


Thr Lys  Ile Lys Gln Leu Leu  Val Lys Thr Lys Lys  Glu Leu Ala 
    1220                 1225                 1230             


Asp Ser  Lys Gln Ala Glu Thr  Asp His Leu Ile Leu  Gln Ala Ser 
    1235                 1240                 1245             


Leu Lys  Gly Glu Leu Glu Ala  Ser Gln Gln Gln Val  Glu Val Tyr 
    1250                 1255                 1260             


Lys Ile  Gln Leu Ala Glu Ile  Thr Ser Glu Lys His  Lys Ile His 
    1265                 1270                 1275             


Glu His  Leu Lys Thr Ser Ala  Glu Gln His Gln Arg  Thr Leu Ser 
    1280                 1285                 1290             


Ala Tyr  Gln Gln Arg Val Thr  Ala Leu Gln Glu Glu  Cys Arg Ala 
    1295                 1300                 1305             


Ala Lys  Ala Glu Gln Ala Thr  Val Thr Ser Glu Phe  Glu Ser Tyr 
    1310                 1315                 1320             


Lys Val  Arg Val His Asn Val  Leu Lys Gln Gln Lys  Asn Lys Ser 
    1325                 1330                 1335             


Met Ser  Gln Ala Glu Thr Glu  Gly Ala Lys Gln Glu  Arg Glu His 
    1340                 1345                 1350             


Leu Glu  Met Leu Ile Asp Gln  Leu Lys Ile Lys Leu  Gln Asp Ser 
    1355                 1360                 1365             


Gln Asn  Asn Leu Gln Ile Asn  Val Ser Glu Leu Gln  Thr Leu Gln 
    1370                 1375                 1380             


Ser Glu  His Asp Thr Leu Leu  Glu Arg His Asn Lys  Met Leu Gln 
    1385                 1390                 1395             


Glu Thr  Val Ser Lys Glu Ala  Glu Leu Arg Glu Lys  Leu Cys Ser 
    1400                 1405                 1410             


Ile Gln  Ser Glu Asn Met Met  Met Lys Ser Glu His  Thr Gln Thr 
    1415                 1420                 1425             


Val Ser  Gln Leu Thr Ser Gln  Asn Glu Val Leu Arg  Asn Ser Phe 
    1430                 1435                 1440             


Arg Asp  Gln Val Arg His Leu  Gln Glu Glu His Arg  Lys Thr Val 
    1445                 1450                 1455             


Glu Thr  Leu Gln Gln Gln Leu  Ser Lys Met Glu Ala  Gln Leu Phe 
    1460                 1465                 1470             


Gln Leu  Lys Asn Glu Pro Thr  Thr Arg Ser Pro Val  Ser Ser Gln 
    1475                 1480                 1485             


Gln Ser  Leu Lys Asn Leu Arg  Glu Arg Arg Asn Thr  Asp Leu Pro 
    1490                 1495                 1500             


Leu Leu  Asp Met His Thr Val  Thr Arg Glu Glu Gly  Glu Gly Met 
    1505                 1510                 1515             


Glu Thr  Thr Asp Thr Glu Ser  Val Ser Ser Ala Ser  Thr Tyr Thr 
    1520                 1525                 1530             


Gln Ser  Leu Glu Gln Leu Leu  Asn Ser Pro Glu Thr  Lys Leu Glu 
    1535                 1540                 1545             


Pro Pro  Leu Trp His Ala Glu  Phe Thr Lys Glu Glu  Leu Val Gln 
    1550                 1555                 1560             


Lys Leu  Ser Ser Thr Thr Lys  Ser Ala Asp His Leu  Asn Gly Leu 
    1565                 1570                 1575             


Leu Arg  Glu Thr Glu Ala Thr  Asn Ala Ile Leu Met  Glu Gln Ile 
    1580                 1585                 1590             


Lys Leu  Leu Lys Ser Glu Ile  Arg Arg Leu Glu Arg  Asn Gln Glu 
    1595                 1600                 1605             


Arg Glu  Lys Ser Ala Ala Asn  Leu Glu Tyr Leu Lys  Asn Val Leu 
    1610                 1615                 1620             


Leu Gln  Phe Ile Phe Leu Lys  Pro Gly Ser Glu Arg  Glu Arg Leu 
    1625                 1630                 1635             


Leu Pro  Val Ile Asn Thr Met  Leu Gln Leu Ser Pro  Glu Glu Lys 
    1640                 1645                 1650             


Gly Lys  Leu Ala Ala Val Ala  Gln Gly Glu Glu Glu  Asn Ala Ser 
    1655                 1660                 1665             


Arg Ser  Ser Gly Trp Ala Ser  Tyr Leu His Ser Trp  Ser Gly Leu 
    1670                 1675                 1680             


Arg 
    


<210>  8165
<211>  6835
<212>  DNA
<213>  Homosapiens

<400>  8165
ctttgacctg cagtagagcc tacgtcagag gctggcgcaa acagaagtgc agcggtggcg     60

gcggctggtt gcgggccggc ggcgggctgg cggagatgga ggatcttgtt caagatgggg    120

tggcttcacc agctacccct gggaccggga aatctaagaa ttggagaaag aaattgaaga    180

actcagatca aaacctgtta ctgaaggaac tggtgatatt attaaggcat taactgaacg    240

tctggatgct cttcttctgg aaaaagcaga gactgagcaa cagtgtcttt ctctgaaaaa    300

ggaaaatata aaaatgaagc aagaggttga ggattctgta acaaagatgg gagatgcaca    360

taaggagttg gaacaatcac atataaacta tgtgaaagaa attgaaaatt tgaaaaatga    420

gttgatggca gtacgttcca aatacagtga agacaaagct aacttacaaa agcagctgga    480

agaagcaatg aatacgcaat tagaactttc agaacaactt aaatttcaga acaactctga    540

agataatgtt aaaaaactac aagaagagat tgagaaaatt aggccaggct ttgaggagca    600

aattttatat ctgcaaaagc aattagacgc taccactgat gaaaagaagg aaacagttac    660

tcaactccaa aatatcattg aggctaattc tcagcattac caaaaaaata ttaatagttt    720

gcaggaagag cttttacagt tgaaagctat acaccaagaa gaggtgaaag agttgatgtg    780

ccagattgaa gcatcagcta aggaacatga agcagagata aataagttga acgagctaaa    840

agagaactta gtaaaacaat gtgaggcaag tgaaaagaac atccagaaga aatatgaatg    900

tgagttagaa aatttaagga aagccacctc aaatgcaaac caagacaatc agatatgttc    960

tattctcttg caagaaaata catttgtaga acaagtagta aatgaaaaag tcaaacactt   1020

agaagatacc ttaaaagaac ttgaatctca acacagtatc ttaaaagatg aggtaactta   1080

tatgaataat cttaagttaa aacttgaaat ggatgctcaa catataaagg atgagttttt   1140

tcatgaacgg gaagacttag agtttaaaat taatgaatta ttactagcta aagaagaaca   1200

gggctgtgta attgaaaaat taaaatctga gctagcaggt ttaaataaac agttttgcta   1260

tactgtagaa cagcataaca gagaagtaca gagtcttaag gaacaacatc aaaaagaaat   1320

atcagaacta aatgagacat ttttgtcaga ttcagaaaaa gaaaaattaa cattaatgtt   1380

tgaaatacag ggtcttaagg aacagtgtga aaacctacag caagaaaagc aagaagcaat   1440

tttaaattat gagagtttac gagagattat ggaaatttta caaacagaac tgggggaatc   1500

tgctggaaaa ataagtcaag agttcgaatc aatgaagcaa cagcaagcat ctgatgttca   1560

tgaactgcag cagaagctca gaactgcttt tactgaaaaa gatgcccttc tcgaaactgt   1620

gaatcgcctc cagggagaaa atgaaaagtt actatctcaa caagaattgg taccagaact   1680

tgaaaatacc ataaagaacc ttcaagaaaa gaatggagta tacttactta gtctcagtca   1740

aagagatacc atgttaaaag aattagaagg aaagataaat tctcttactg aggaaaaaga   1800

tgattttata aataaactga aaaattccca tgaagaaatg gataatttcc ataagaaatg   1860

tgaaagggaa gaaagattga ttcttgaact tgggaagaaa gtagagcaaa caatccagta   1920

caacagtgaa ctagaacaaa aggtaaatga attaacagga ggactagagg agactttaaa   1980

agaaaaggat caaaatgacc aaaaactaga aaaacttatg gttcaaatga aagttctctc   2040

tgaagacaaa gaagtattgt cagctgaagt gaagtctctt tatgaggaaa acaataaact   2100

cagttcagaa aaaaaacagt tgagtaggga tttggaggtt tttttgtctc aaaaagaaga   2160

tgttatcctt aaagaacata ttactcaatt agaaaagaaa cttcagttaa tggttgaaga   2220

gcaagataat ttaaataaac tgcttgaaaa tgagcaagtt cagaagttat ttgttaaaac   2280

tcagttgtat ggttttctta aagaaatggg atcagaagtt tcagaagaca gtgaagagaa   2340

agatgttgtt aatgtcctac aggcagtcgg tgaatccttg gcaaaaataa atgaggaaaa   2400

atgcaacctg gcttttcagc gtgatgaaaa agtattagag ttagaaaaag agattaagtg   2460

ccttcaagaa gagagtgtag ttcagtgtga agaacttaag tctttattga gagactatga   2520

gcaagagaaa gttctcttaa ggaaagagtt agaagaaata cagtcagaaa aagaggccct   2580

gcagtctgat cttctagaaa tgaagaatgc taatgaaaaa acaaggcttg aaaatcagaa   2640

tcttttaatt caagttgaag aagtatctca aacatgtagc aaaagtgaaa tccataatga   2700

aaaagaaaaa tgttttataa aggaacatga aaacctaaag ccactactag aacaaaaaga   2760

attacgagat aggagagcag agttgatact attaaaggat tccttagcaa aatcaccttc   2820

tgtaaaaaat gatcctctgt cttcagtaaa agagttggaa gaaaaaatag aaaatctgga   2880

aaaagaatgc aaagaaaagg aggagaaaat aaataagata aaattagttg ccgtaaaggc   2940

aaagaaagaa ctagattcca gcagaaaaga gacccagact gtgaaggaag aacttgaatc   3000

tcttcgatca gaaaaggacc agttatctgc ttccatgaga gatctcattc aaggagcaga   3060

aagctataag aatcttttat tagaatatga aaagcagtca gagcaactgg atgtggaaaa   3120

agaacgtgct aataattttg agcatcgtat tgaagacctt acaagacaat taagaaattc   3180

gactttgcag tgtgaaacaa taaattctga taatgaagat ctcctggctc gtattgagac   3240

attacagtct aatgccaaat tattagaagt acagatttta gaagtccaga gagccaaagc   3300

aatggtagac aaagaattag aagctgaaaa acttcagaaa gaacagaaga taaaggaaca   3360

tgccactact gtaaatgaac ttgaagaact tcaggtacaa cttcaaaagc aaaagaaaca   3420

gcttcagaaa accatgcaag aattagagct ggttaaaaag gatgcccaac aaaccacatt   3480

gatgaatatg gaaatagctg attatgaacg tttgatgaaa gaactaaatc aaaagttaac   3540

taataaaaac aacaagatag aagatttgga gcaagaaata aaaattcaaa aacagaaaca   3600

agaaacccta caagaagaaa taacttcatt acagtcttca gtacaacaat atgaagaaaa   3660

aaacaccaaa atcaagcaat tgcttgtgaa aaccaaaaag gaactggcag attcaaagca   3720

agcagaaact gatcacttaa tacttcaagc atctttaaaa ggtgagctgg aggcaagcca   3780

gcagcaagta gaagtctata aaatacagct ggctgaaata acatcagaga agcacaaaat   3840

ccacgagcac ctgaaaacct ctgcggaaca gcaccagcgt acgctaagtg cataccagca   3900

gagagtgaca gcactacagg aagagtgccg tgctgccaag gcagaacaag ctactgtaac   3960

ctctgaattc gagagctaca aagtccgagt tcataatgtt ctaaaacaac agaaaaataa   4020

atctatgtct caggctgaaa ctgagggcgc taaacaagaa agggaacatc tggaaatgct   4080

gattgaccag ctaaaaatca aattacaaga tagccaaaat aacttacaga ttaatgtatc   4140

tgaacttcaa acattgcagt ctgaacatga tacactgcta gaaaggcaca acaagatgct   4200

gcaggaaact gtgtccaaag aggcggaact ccgggaaaaa ttgtgttcaa tacagtcaga   4260

gaacatgatg atgaaatctg aacatacaca gactgtgagt cagctaacat cccagaacga   4320

ggtccttcga aatagcttcc gagatcaagt gcgacatttg caggaagaac acagaaagac   4380

agtggagaca ttacagcagc agctctccaa gatggaagca cagctcttcc agcttaagaa   4440

tgaaccgacc acaagaagcc cagtttcctc tcaacaatct ttgaagaacc ttcgagaaag   4500

gagaaacaca gacctcccgc ttctagacat gcacactgta acccgggaag agggagaagg   4560

catggagaca actgatacgg agtctgtgtc ttccgccagc acatacacac agtctttaga   4620

gcagctgctt aactctcccg aaactaaact tgagcctcca ttatggcatg ctgaatttac   4680

caaagaagaa ttggttcaga agctcagttc caccacaaaa agtgcagatc acttaaacgg   4740

cctgcttcgg gaaacagaag caaccaatgc aattcttatg gagcaaatta agcttctcaa   4800

aagtgaaata agaagattgg aaaggaatca agagcgagag aagtctgcag ctaacctgga   4860

atacttgaag aacgtcttgc tgcagttcat tttcttgaaa ccaggtagtg aaagagagag   4920

acttcttcct gttataaata cgatgttgca gctcagccct gaagaaaagg gaaaacttgc   4980

tgcggttgct caaggtgagg aagaaaatgc ttcccgttct tctggatggg catcctatct   5040

tcatagttgg tctggacttc gataggttga tggaaggaat atttttatta accaaataga   5100

atctatttac aaaaatggtt cacgtatatt accacaattc ttttgtcaaa aagtgtgtat   5160

atatgtttgc atctacatat atttgtacat ctatatgaca gatgtatttt aaaagtttca   5220

tcttgaagta aaagtacaac agcttgaagt gttgatagca ggccacagcc ctctaactca   5280

tgtgatttcc catgcatgct gccagaataa aaccaccagg aatgaattca ctccccactt   5340

ctctggaacc tcaggacccg cccatttctc ggcagtactg tgaattttga agttaaacta   5400

aattttggta ccataccaac tggaatttag gctttaaaaa taatgtttca aggccaggtg   5460

tggtgattca tgcctgaaat cccactactt tgggaggctg aggctggaga attgcttgag   5520

gctagtgagc tgtgactccc actgcactcc agctcgggga acagagcgag accttgtctc   5580

taaaaataat agtaataaaa taaaaataac gttttatgac tatttattgc aaggtcagag   5640

ttacagattg ttataaattg ttgagaaatt tttgtgatta gaatatgaag gaaaaagctt   5700

tgttggtaaa agtgacatgt taaggggcta tgaagtaaat atgctgcagt taattatgct   5760

aagttaaaat acagtttagt tatttgcttt aaaataaact cttctttttt tctttaaagt   5820

atactatctc aaaactcatt atgttgtcag agccctagag ctggctagtg taacactgac   5880

tatgagtagg tgggcccaca cttgagttga ggtgatttca tggtgtcttt ccaggctctt   5940

gatagggtgt cactgcatgc aagccatgaa tctgttttga gaatcctctc cattttccca   6000

aataaaaacc tatcacaaca gtgactatat cactcagcat tggatctaaa tataaaagtg   6060

gtgctttcag tgtttttggc agatagtgtt ccataagctt tccatcagaa gggattttag   6120

acaccttaga ggtccgtgct acatcgtcac agttcctccg aataacctta ggtggtagtg   6180

ttacttgcct ttgacacctc tgcatatgtt ttaatgacta gatccaaact gtgttgttct   6240

taaatcaaaa attggataat ttgtaatatt tatgtgttaa tcacacagta tgctctctga   6300

agttctctta agccttcagt ttatactctt aatttaattt tctttctgag ctggagaact   6360

ggctttgcac tttggttaca cagaacattg gtttccaatt cagtttaact gaaatttgct   6420

gctgatatgt tgagtttgtt ctttaaaaaa tagctcatat atctcatctt tcctcctgtc   6480

ttagaagaac agacctaact agtgaatgta ttaatgaaaa tgcatctatt tcagagctga   6540

catgaagagt ttagtttttt tactttataa actgtgaata tgagtatgcc agctgcatac   6600

gatgtaacta atcatattta aatatatttc actttctctt tgactttaga ccttttgaag   6660

tctgtataaa cttgttttga aatatagtct ctgcttacga atgtcataac aaaataattt   6720

tttgcatgat aaaaaattac tttgattaca aaaggcatat tctttcatgg tttctgcaat   6780

gagaggaagt gtaatgatta ttttaatatt tctattaaat atgtttaact gtata        6835


<210>  8166
<211>  1583
<212>  PRT
<213>  Homosapiens

<400>  8166

Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys Met Gly Asp Ala His 
1               5                   10                  15      


Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val Lys Glu Ile Glu Asn 
            20                  25                  30          


Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys Tyr Ser Glu Asp Lys 
        35                  40                  45              


Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met Asn Thr Gln Leu Glu 
    50                  55                  60                  


Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser Glu Asp Asn Val Lys 
65                  70                  75                  80  


Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro Gly Phe Glu Glu Gln 
                85                  90                  95      


Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr Thr Asp Glu Lys Lys 
            100                 105                 110         


Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu Ala Asn Ser Gln His 
        115                 120                 125             


Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu Leu Leu Gln Leu Lys 
    130                 135                 140                 


Ala Ile His Gln Glu Glu Val Lys Glu Leu Met Cys Gln Ile Glu Ala 
145                 150                 155                 160 


Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys Leu Asn Glu Leu Lys 
                165                 170                 175     


Glu Asn Leu Val Lys Gln Cys Glu Ala Ser Glu Lys Asn Ile Gln Lys 
            180                 185                 190         


Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys Ala Thr Ser Asn Ala 
        195                 200                 205             


Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu Gln Glu Asn Thr Phe 
    210                 215                 220                 


Val Glu Gln Val Val Asn Glu Lys Val Lys His Leu Glu Asp Thr Leu 
225                 230                 235                 240 


Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys Asp Glu Val Thr Tyr 
                245                 250                 255     


Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp Ala Gln His Ile Lys 
            260                 265                 270         


Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu Phe Lys Ile Asn Glu 
        275                 280                 285             


Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val Ile Glu Lys Leu Lys 
    290                 295                 300                 


Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys Tyr Thr Val Glu Gln 
305                 310                 315                 320 


His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln His Gln Lys Glu Ile 
                325                 330                 335     


Ser Glu Leu Asn Glu Thr Phe Leu Ser Asp Ser Glu Lys Glu Lys Leu 
            340                 345                 350         


Thr Leu Met Phe Glu Ile Gln Gly Leu Lys Glu Gln Cys Glu Asn Leu 
        355                 360                 365             


Gln Gln Glu Lys Gln Glu Ala Ile Leu Asn Tyr Glu Ser Leu Arg Glu 
    370                 375                 380                 


Ile Met Glu Ile Leu Gln Thr Glu Leu Gly Glu Ser Ala Gly Lys Ile 
385                 390                 395                 400 


Ser Gln Glu Phe Glu Ser Met Lys Gln Gln Gln Ala Ser Asp Val His 
                405                 410                 415     


Glu Leu Gln Gln Lys Leu Arg Thr Ala Phe Thr Glu Lys Asp Ala Leu 
            420                 425                 430         


Leu Glu Thr Val Asn Arg Leu Gln Gly Glu Asn Glu Lys Leu Leu Ser 
        435                 440                 445             


Gln Gln Glu Leu Val Pro Glu Leu Glu Asn Thr Ile Lys Asn Leu Gln 
    450                 455                 460                 


Glu Lys Asn Gly Val Tyr Leu Leu Ser Leu Ser Gln Arg Asp Thr Met 
465                 470                 475                 480 


Leu Lys Glu Leu Glu Gly Lys Ile Asn Ser Leu Thr Glu Glu Lys Asp 
                485                 490                 495     


Asp Phe Ile Asn Lys Leu Lys Asn Ser His Glu Glu Met Asp Asn Phe 
            500                 505                 510         


His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile Leu Glu Leu Gly Lys 
        515                 520                 525             


Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu Leu Glu Gln Lys Val 
    530                 535                 540                 


Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu Lys Glu Lys Asp Gln 
545                 550                 555                 560 


Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln Met Lys Val Leu Ser 
                565                 570                 575     


Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys Ser Leu Tyr Glu Glu 
            580                 585                 590         


Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu Ser Arg Asp Leu Glu 
        595                 600                 605             


Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu Lys Glu His Ile Thr 
    610                 615                 620                 


Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu Glu Gln Asp Asn Leu 
625                 630                 635                 640 


Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys Leu Phe Val Lys Thr 
                645                 650                 655     


Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser Glu Val Ser Glu Asp 
            660                 665                 670         


Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln Ala Val Gly Glu Ser 
        675                 680                 685             


Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu Ala Phe Gln Arg Asp 
    690                 695                 700                 


Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys Cys Leu Gln Glu Glu 
705                 710                 715                 720 


Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu Leu Arg Asp Tyr Glu 
                725                 730                 735     


Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu Glu Ile Gln Ser Glu 
            740                 745                 750         


Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met Lys Asn Ala Asn Glu 
        755                 760                 765             


Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile Gln Val Glu Glu Val 
    770                 775                 780                 


Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn Glu Lys Glu Lys Cys 
785                 790                 795                 800 


Phe Ile Lys Glu His Glu Asn Leu Lys Pro Leu Leu Glu Gln Lys Glu 
                805                 810                 815     


Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu Lys Asp Ser Leu Ala 
            820                 825                 830         


Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser Ser Val Lys Glu Leu 
        835                 840                 845             


Glu Glu Lys Ile Glu Asn Leu Glu Lys Glu Cys Lys Glu Lys Glu Glu 
    850                 855                 860                 


Lys Ile Asn Lys Ile Lys Leu Val Ala Val Lys Ala Lys Lys Glu Leu 
865                 870                 875                 880 


Asp Ser Ser Arg Lys Glu Thr Gln Thr Val Lys Glu Glu Leu Glu Ser 
                885                 890                 895     


Leu Arg Ser Glu Lys Asp Gln Leu Ser Ala Ser Met Arg Asp Leu Ile 
            900                 905                 910         


Gln Gly Ala Glu Ser Tyr Lys Asn Leu Leu Leu Glu Tyr Glu Lys Gln 
        915                 920                 925             


Ser Glu Gln Leu Asp Val Glu Lys Glu Arg Ala Asn Asn Phe Glu His 
    930                 935                 940                 


Arg Ile Glu Asp Leu Thr Arg Gln Leu Arg Asn Ser Thr Leu Gln Cys 
945                 950                 955                 960 


Glu Thr Ile Asn Ser Asp Asn Glu Asp Leu Leu Ala Arg Ile Glu Thr 
                965                 970                 975     


Leu Gln Ser Asn Ala Lys Leu Leu Glu Val Gln Ile Leu Glu Val Gln 
            980                 985                 990         


Arg Ala Lys Ala Met Val Asp Lys  Glu Leu Glu Ala Glu  Lys Leu Gln 
        995                 1000                 1005             


Lys Glu  Gln Lys Ile Lys Glu  His Ala Thr Thr Val  Asn Glu Leu 
    1010                 1015                 1020             


Glu Glu  Leu Gln Val Gln Leu  Gln Lys Gln Lys Lys  Gln Leu Gln 
    1025                 1030                 1035             


Lys Thr  Met Gln Glu Leu Glu  Leu Val Lys Lys Asp  Ala Gln Gln 
    1040                 1045                 1050             


Thr Thr  Leu Met Asn Met Glu  Ile Ala Asp Tyr Glu  Arg Leu Met 
    1055                 1060                 1065             


Lys Glu  Leu Asn Gln Lys Leu  Thr Asn Lys Asn Asn  Lys Ile Glu 
    1070                 1075                 1080             


Asp Leu  Glu Gln Glu Ile Lys  Ile Gln Lys Gln Lys  Gln Glu Thr 
    1085                 1090                 1095             


Leu Gln  Glu Glu Ile Thr Ser  Leu Gln Ser Ser Val  Gln Gln Tyr 
    1100                 1105                 1110             


Glu Glu  Lys Asn Thr Lys Ile  Lys Gln Leu Leu Val  Lys Thr Lys 
    1115                 1120                 1125             


Lys Glu  Leu Ala Asp Ser Lys  Gln Ala Glu Thr Asp  His Leu Ile 
    1130                 1135                 1140             


Leu Gln  Ala Ser Leu Lys Gly  Glu Leu Glu Ala Ser  Gln Gln Gln 
    1145                 1150                 1155             


Val Glu  Val Tyr Lys Ile Gln  Leu Ala Glu Ile Thr  Ser Glu Lys 
    1160                 1165                 1170             


His Lys  Ile His Glu His Leu  Lys Thr Ser Ala Glu  Gln His Gln 
    1175                 1180                 1185             


Arg Thr  Leu Ser Ala Tyr Gln  Gln Arg Val Thr Ala  Leu Gln Glu 
    1190                 1195                 1200             


Glu Cys  Arg Ala Ala Lys Ala  Glu Gln Ala Thr Val  Thr Ser Glu 
    1205                 1210                 1215             


Phe Glu  Ser Tyr Lys Val Arg  Val His Asn Val Leu  Lys Gln Gln 
    1220                 1225                 1230             


Lys Asn  Lys Ser Met Ser Gln  Ala Glu Thr Glu Gly  Ala Lys Gln 
    1235                 1240                 1245             


Glu Arg  Glu His Leu Glu Met  Leu Ile Asp Gln Leu  Lys Ile Lys 
    1250                 1255                 1260             


Leu Gln  Asp Ser Gln Asn Asn  Leu Gln Ile Asn Val  Ser Glu Leu 
    1265                 1270                 1275             


Gln Thr  Leu Gln Ser Glu His  Asp Thr Leu Leu Glu  Arg His Asn 
    1280                 1285                 1290             


Lys Met  Leu Gln Glu Thr Val  Ser Lys Glu Ala Glu  Leu Arg Glu 
    1295                 1300                 1305             


Lys Leu  Cys Ser Ile Gln Ser  Glu Asn Met Met Met  Lys Ser Glu 
    1310                 1315                 1320             


His Thr  Gln Thr Val Ser Gln  Leu Thr Ser Gln Asn  Glu Val Leu 
    1325                 1330                 1335             


Arg Asn  Ser Phe Arg Asp Gln  Val Arg His Leu Gln  Glu Glu His 
    1340                 1345                 1350             


Arg Lys  Thr Val Glu Thr Leu  Gln Gln Gln Leu Ser  Lys Met Glu 
    1355                 1360                 1365             


Ala Gln  Leu Phe Gln Leu Lys  Asn Glu Pro Thr Thr  Arg Ser Pro 
    1370                 1375                 1380             


Val Ser  Ser Gln Gln Ser Leu  Lys Asn Leu Arg Glu  Arg Arg Asn 
    1385                 1390                 1395             


Thr Asp  Leu Pro Leu Leu Asp  Met His Thr Val Thr  Arg Glu Glu 
    1400                 1405                 1410             


Gly Glu  Gly Met Glu Thr Thr  Asp Thr Glu Ser Val  Ser Ser Ala 
    1415                 1420                 1425             


Ser Thr  Tyr Thr Gln Ser Leu  Glu Gln Leu Leu Asn  Ser Pro Glu 
    1430                 1435                 1440             


Thr Lys  Leu Glu Pro Pro Leu  Trp His Ala Glu Phe  Thr Lys Glu 
    1445                 1450                 1455             


Glu Leu  Val Gln Lys Leu Ser  Ser Thr Thr Lys Ser  Ala Asp His 
    1460                 1465                 1470             


Leu Asn  Gly Leu Leu Arg Glu  Thr Glu Ala Thr Asn  Ala Ile Leu 
    1475                 1480                 1485             


Met Glu  Gln Ile Lys Leu Leu  Lys Ser Glu Ile Arg  Arg Leu Glu 
    1490                 1495                 1500             


Arg Asn  Gln Glu Arg Glu Lys  Ser Ala Ala Asn Leu  Glu Tyr Leu 
    1505                 1510                 1515             


Lys Asn  Val Leu Leu Gln Phe  Ile Phe Leu Lys Pro  Gly Ser Glu 
    1520                 1525                 1530             


Arg Glu  Arg Leu Leu Pro Val  Ile Asn Thr Met Leu  Gln Leu Ser 
    1535                 1540                 1545             


Pro Glu  Glu Lys Gly Lys Leu  Ala Ala Val Ala Gln  Gly Glu Glu 
    1550                 1555                 1560             


Glu Asn  Ala Ser Arg Ser Ser  Gly Trp Ala Ser Tyr  Leu His Ser 
    1565                 1570                 1575             


Trp Ser  Gly Leu Arg 
    1580             


<210>  8167
<211>  1372
<212>  DNA
<213>  Homosapiens

<400>  8167
gtcagaggct ggcgcaaaca gaagtgcagc ggtggcggcg gctggttgcg ggccggcggc     60

gggctggcgg agatggagga tcttgttcaa gatggggtgg cttcaccagc tacccctggg    120

accgggaaat ctaagctgga aacattgccc aaagaagacc tcatcaagtt tgccaagaaa    180

cagatgatgc taatacagaa agctaaatca aggtgtacag aattggagaa agaaattgaa    240

gaactcagat caaaacctgt tactgaagga actggtgata ttattaaggc attaactgaa    300

cgtctggatg ctcttcttct ggaaaaagca gagactgagc aacagtgtct ttctctgaaa    360

aaggaaaata taaaaatgaa gcaagaggtt gaggattctg taacaaagat gggagatgca    420

cataaggagt tggaacaatc acatataaac tatgtgaaag aaattgaaaa tttgaaaaat    480

gagttgatgg cagtacgttc caaatacagt gaagacaaag ctaacttaca aaagcagctg    540

gaagaagcaa tgaatacgca attagaactt tcagaacaac ttaaatttca gaacaactct    600

gaagataatg ttaaaaaact acaagaagag attgagaaaa ttaggccagg ctttgaggag    660

caaattttat atctgcaaaa gcaattagac gctaccactg atgaaaagaa ggaaacagtt    720

actcaactcc aaaatatcat tgaggctaat tctcagcatt accaaaaaaa tattaatagt    780

ttgcaggaag agcttttaca gttgaaagct atacaccaag aagaggtgaa agagttgatg    840

tgccagattg aagcatcagc taaggaacat gaagcagaga taaataagtt gaacgagcta    900

aaagagaact tagtaaaaca atgtgaggca agtgaaaaga acatccagaa gaaatatgaa    960

tgtgagttag aaaatttaag gaaagccacc tcaaatgcaa accaagacaa tcagatatgt   1020

tctattctct tgcaagaaaa tacatttgta gaacaagtag taaatgaaaa agtcaaacac   1080

ttagaagata ccttaaaaga acttgaatct caacacagta tcttaaaaga tgaggtaact   1140

tatatgaata atcttaagtt aaaacttgaa atggatgctc aacatataaa ggatgagttt   1200

tttcatgaac gggaagactt agagtttaaa attaatgaat tattactagc taaagaagaa   1260

cagggctgtg taattgaaaa attaaaatct gagctagcag gtttaaataa acagttttgc   1320

tatactgtag aacagcataa cagagaagta cagagtctta aggaacaaca tc           1372


<210>  8168
<211>  432
<212>  PRT
<213>  Homosapiens

<400>  8168

Met Glu Asp Leu Val Gln Asp Gly Val Ala Ser Pro Ala Thr Pro Gly 
1               5                   10                  15      


Thr Gly Lys Ser Lys Leu Glu Thr Leu Pro Lys Glu Asp Leu Ile Lys 
            20                  25                  30          


Phe Ala Lys Lys Gln Met Met Leu Ile Gln Lys Ala Lys Ser Arg Cys 
        35                  40                  45              


Thr Glu Leu Glu Lys Glu Ile Glu Glu Leu Arg Ser Lys Pro Val Thr 
    50                  55                  60                  


Glu Gly Thr Gly Asp Ile Ile Lys Ala Leu Thr Glu Arg Leu Asp Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Ala Glu Thr Glu Gln Gln Cys Leu Ser Leu Lys 
                85                  90                  95      


Lys Glu Asn Ile Lys Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys 
            100                 105                 110         


Met Gly Asp Ala His Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val 
        115                 120                 125             


Lys Glu Ile Glu Asn Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys 
    130                 135                 140                 


Tyr Ser Glu Asp Lys Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met 
145                 150                 155                 160 


Asn Thr Gln Leu Glu Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser 
                165                 170                 175     


Glu Asp Asn Val Lys Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro 
            180                 185                 190         


Gly Phe Glu Glu Gln Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr 
        195                 200                 205             


Thr Asp Glu Lys Lys Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu 
    210                 215                 220                 


Ala Asn Ser Gln His Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu 
225                 230                 235                 240 


Leu Leu Gln Leu Lys Ala Ile His Gln Glu Glu Val Lys Glu Leu Met 
                245                 250                 255     


Cys Gln Ile Glu Ala Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys 
            260                 265                 270         


Leu Asn Glu Leu Lys Glu Asn Leu Val Lys Gln Cys Glu Ala Ser Glu 
        275                 280                 285             


Lys Asn Ile Gln Lys Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys 
    290                 295                 300                 


Ala Thr Ser Asn Ala Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu 
305                 310                 315                 320 


Gln Glu Asn Thr Phe Val Glu Gln Val Val Asn Glu Lys Val Lys His 
                325                 330                 335     


Leu Glu Asp Thr Leu Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys 
            340                 345                 350         


Asp Glu Val Thr Tyr Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp 
        355                 360                 365             


Ala Gln His Ile Lys Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu 
    370                 375                 380                 


Phe Lys Ile Asn Glu Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val 
385                 390                 395                 400 


Ile Glu Lys Leu Lys Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys 
                405                 410                 415     


Tyr Thr Val Glu Gln His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln 
            420                 425                 430         


<210>  8169
<211>  543
<212>  DNA
<213>  Homosapiens

<400>  8169
gaagtgcagc ggtggcggcg gctggttgcg ggccggcggc gggctggcgg agatggagga     60

tcttgttcaa gatggggtgg cttcaccagc tacccctggg accgggaaat ctaagaattg    120

gagaaagaaa ttgaagaact cagatcaaaa cctgttactg aaggaactgg tgatattatt    180

aagagtcttg ctctgtcgcc caggctggag tgcaatgacg tgatctcggc tcactgcaac    240

ctctacctcc tgggttcaag cgattctcct gcctcaagct cgcattaact gaacgtctgg    300

atgctcttct tctggaaaaa gcagagactg agcaacagtg tctttctctg aaaaaggaaa    360

atataaaaat gaagcaagag gttgagctat aatgccatct ttactaaaag cgaaaaaaag    420

taagttgatt ttcacacatg actaaatacc attatctctt tagttctacg gtattcagag    480

gcatttcttg cctatttctt gcctattagg tctgggctaa tttgagtaat agatttaata    540

ttg                                                                  543


<210>  8170
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  8170

Met Glu Asp Leu Val Gln Asp Gly Val Ala Ser Pro Ala Thr Pro Gly 
1               5                   10                  15      


Thr Gly Lys Ser Lys Asn Trp Arg Lys Lys Leu Lys Asn Ser Asp Gln 
            20                  25                  30          


Asn Leu Leu Leu Lys Glu Leu Val Ile Leu Leu Arg Val Leu Leu Cys 
        35                  40                  45              


Arg Pro Gly Trp Ser Ala Met Thr 
    50                  55      


<210>  8171
<211>  2125
<212>  DNA
<213>  Homosapiens

<400>  8171
actgaaaaat tcccatgaag aaatggataa tttccataag aaatgtgaaa gggaagaaag     60

attgattctt gaacttggga agaaagtaga gcaaacaatc cagtacaaca gtgaactaga    120

acaaaaggta aatgaattaa caggaggact agaggagact ttaaaagaaa aggatcaaaa    180

tgaccaaaaa ctagaaaaac ttatggttca aatgaaagtt ctctctgaag acaaagaagt    240

attgtcagct gaagtgaagt ctctttatga ggaaaacaat aaactcagtt cagaaaaaaa    300

acagttgagt agggatttgg aggttttttt gtctcaaaaa gaagatgtta tccttaaaga    360

acatattact caattagaaa agaaacttca gttaatggtt gaagagcaag ataatttaaa    420

taaactgctt gaaaatgagc aagttcagaa gttatttgtt aaaactcagt tgtatggttt    480

tcttaaagaa atgggatcag aagtttcaga agacagtgaa gagaaagatg ttgttaatgt    540

cctacaggca gtcggtgaat ccttggcaaa aataaatgag gaaaaatgca acctggcttt    600

tcagcgtgat gaaaaagtat tagagttaga aaaagagatt aagtgccttc aagaagagag    660

tgtagttcag tgtgaagaac ttaagtcttt attgagagac tatgagcaag agaaagttct    720

cttaaggaaa gagttagaag aaatacagtc agaaaaagag gccctgcagt ctgatcttct    780

agaaatgaag aatgctaatg aaaaaacaag gcttgaaaat cagaatcttt taattcaagt    840

tgaagaagta tctcaaacat gtagcaaaag tgaaatccat aatgaaaaag aaaaatgttt    900

tataaaggaa catgaaaacc taaagccact actagaacaa aaagaattac gagataggag    960

agcagagttg atactattaa aggattcctt agcaaaatca ccttctgtaa aaaatgatcc   1020

tctgtcttca gtaaaagagt tggaagaaaa aataggtaac tatggttttg cagatgttgt   1080

cacaattaat tagacagatt cttcttagtg ttagaataga ttgggaaata tagtagccaa   1140

ataatgagtt gttaaaaaca cagttcgtag ctgtcttttc ctcgagctca cattcttgcc   1200

cctctaacac ctgtttgcct tctctttcaa aagtgttact ttctattgtt taacccaagc   1260

aagattggtg tgatttataa atggcttcat gatttatttt ggatttttca ttcatttagc   1320

aaattttatt taaatgccca actattctag accctggtga tagaaaagtg gttgaggtac   1380

agaccatgtg ctcagagatc tcactgttgt ttgaggtgtg gacaagatac agtactaaca   1440

gcataggaac ttaacactgt tttgagttaa aaaaaaaaaa aaaagcagcg tagaataggg   1500

ttttcagcca agtcttgaag aatgagaaat tttacacagg aagaaaggta ttctaggaag   1560

aaggaagagc aggtgcttgt aggttgacat atagcataca tcaaggcacg tactaggaag   1620

ttcctggaga ggtaggagcc tgatcataaa cacactagta tgattgatat gcagaggagt   1680

taggacttta tcttatccat ttattcctca cagtaacatt ataggatagc tcttttattc   1740

ccatataaga atcaggaaac gaagacttag aagtatgtaa tgtgccaatg atccctgaat   1800

ttagtaccct gttagattag ggtaagggaa gttgaagagt ttagaatgac tcccagttgt   1860

ctataatggg tgattggggc agattgggat gttcagtttt agaattaagt ttaaatacca   1920

gtccaagtaa agatgttaga atgctatgca aatctggagt taaggggaga gagctaagct   1980

agagataaat acttctagtt aaagagtggt cattaaaagc caggagaggc cgagtgcggt   2040

ggctcacgcc tataatccca gcactttggg aggcctaagt gggcggatca cgaggtcagg   2100

agattgagac catcctggct aacac                                         2125


<210>  8172
<211>  356
<212>  PRT
<213>  Homosapiens

<400>  8172

Met Asp Asn Phe His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile Leu 
1               5                   10                  15      


Glu Leu Gly Lys Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu Leu 
            20                  25                  30          


Glu Gln Lys Val Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu Lys 
        35                  40                  45              


Glu Lys Asp Gln Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln Met 
    50                  55                  60                  


Lys Val Leu Ser Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys Ser 
65                  70                  75                  80  


Leu Tyr Glu Glu Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu Ser 
                85                  90                  95      


Arg Asp Leu Glu Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu Lys 
            100                 105                 110         


Glu His Ile Thr Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu Glu 
        115                 120                 125             


Gln Asp Asn Leu Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys Leu 
    130                 135                 140                 


Phe Val Lys Thr Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser Glu 
145                 150                 155                 160 


Val Ser Glu Asp Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln Ala 
                165                 170                 175     


Val Gly Glu Ser Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu Ala 
            180                 185                 190         


Phe Gln Arg Asp Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys Cys 
        195                 200                 205             


Leu Gln Glu Glu Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu Leu 
    210                 215                 220                 


Arg Asp Tyr Glu Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu Glu 
225                 230                 235                 240 


Ile Gln Ser Glu Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met Lys 
                245                 250                 255     


Asn Ala Asn Glu Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile Gln 
            260                 265                 270         


Val Glu Glu Val Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn Glu 
        275                 280                 285             


Lys Glu Lys Cys Phe Ile Lys Glu His Glu Asn Leu Lys Pro Leu Leu 
    290                 295                 300                 


Glu Gln Lys Glu Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu Lys 
305                 310                 315                 320 


Asp Ser Leu Ala Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser Ser 
                325                 330                 335     


Val Lys Glu Leu Glu Glu Lys Ile Gly Asn Tyr Gly Phe Ala Asp Val 
            340                 345                 350         


Val Thr Ile Asn 
        355     


<210>  8173
<211>  524
<212>  DNA
<213>  Homosapiens

<400>  8173
gggaggctgg cgcaaacgca gcgggtggct ggggtagggg ctcattggga gcccacggag     60

cgcggcggcg gctcgggggc cgagttccct acaacaagga tggcggtgac gggcgcaggg    120

agcggggccc ggctctcctt gcctcgaggc tcctctgatt ccactcgcgt ggctgcgcgg    180

ccctggcagc ggccttcgtc ccgggggtgg gagctacaca gggttccgcc ccgtcctggc    240

gaggacgcct gagggggctc tgtggtaagg ctctgtcggg caggccgggc ttccgggagg    300

acctggtctg gatcggtcac cgctgggtgc ctgagctccg catggagcct gcagcctttg    360

tttaacttat aaagaaatgg gggctccgag cagtcaagaa gaacatgccc caagttattc    420

gtcagtgagg cggaaattgt ggtgtacttg ttccagacca actatgaaga taggatgccc    480

atccagaaga acgggaagca ttttcttcct cacctttgga aagt                     524


<210>  8174
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  8174

Met Gly Ala Pro Ser Ser Gln Glu Glu His Ala Pro Ser Tyr Ser Ser 
1               5                   10                  15      


Val Arg Arg Lys Leu Trp Cys Thr Cys Ser Arg Pro Thr Met Lys Ile 
            20                  25                  30          


Gly Cys Pro Ser Arg Arg Thr Gly Ser Ile Phe Phe Leu Thr Phe Gly 
        35                  40                  45              


<210>  8175
<211>  2529
<212>  DNA
<213>  Homosapiens

<400>  8175
atttcagcac cccaggctag tctgggaggc tggcgcaaac gcagcgggtg gctggggtag     60

gggctcattg ggagcccacg gagcgcggcg gcggctcggg ggccgagttc cctacaacaa    120

ggatggcggt gacgggcgca gggagcgggg cccggctctc cttgcctcga ggctcctctg    180

attccactcg cgtggctgcg cggccctggc agcggccttc gtcccggggg tgggagctac    240

acagggttcc gccccgtcct ggcgaggacg cctgaggggg ctctgtggta aggctctgtc    300

gggcaggccg ggcttccggg aggacctggt ctggatcggt caccgctggg tgcctgagct    360

ccgcatggag cctgcagcct ttgtttaact tataaagaaa tgggggctcc gagcagtcaa    420

gaagaacatg ccccaagtta ttcgtcagtg aggcggaaat tgtggtgtac ttgtgtaagt    480

tcacatttta tactttacca ttatactgtg ctccaaatta tctgatattt actttcaaag    540

catgtgtaga aagtttacta tgatgatgca gagacattgt acagaatcca gtcccttgac    600

tctcaggtcc ccagaacact cacttcacga ttttgttgac ctcttctgtc aacttaaacc    660

tggcactctc ttggctggct ttctctgctc tttctgggca ctccaaagct tctgtactta    720

catgctacaa ttccagtcac aggaagatgc tgagttcttt agtcccagat ccatattcct    780

gagaaaacct aattgcctag gctcaggtca taactctgta tctgtttcag ttgattatgg    840

ctgggcctac tgcccctctg tatggtggtg gggcagaagt tcccagagag aggcaggggt    900

gacagggact gttgtctcaa atgctaggca gacatctgga gtggtaacca ctacatctgt    960

tcacagtgag cacatccttg cagggaaact gggttaatca tctctattat tgaaactcag   1020

aggtatagtg tttcttcata ggaattttct ttccttattt gagatggggg tctcactttg   1080

ttgcccaggc tggagtgcag tggtgtgtga tcttggctca ctgcagcctc ccctcccgag   1140

ttcaagtgat tctcctacct cagcctgctg agtagctggg actacaggca tgggccaaca   1200

tgcctggcta atttttgtat ttttcgtaga gacaagtttt caccatattg gccaggctgg   1260

tcttggactc ctgacctcag gtgatctgcc caccctggcc tccctaagtg ccgggatgac   1320

aggtgtgagc catcgcgccc ggcctattta taggaatttt ctgtaggtat ataagtaata   1380

atttgaaggt cccaactaga tgccttttcg tgtaaccgta tcttgaatgg aacattttct   1440

ttctacgtaa ttatacataa ataacccaat gctttttaat acccacgaaa aaccattagc   1500

tcaaagacac ttgcaaactt gtatcaggtt gttctccttg gtgtgtatta agtttgaagc   1560

aaaggggatt ttcagatacc aagacgaagc agaagtcttc caccaagttg aaatcatcac   1620

gttgcaattt aatcatatga tacaaccaat tttttgatgt gttatgccat tcgccaaata   1680

ccaaaaattt tttaggggaa actttacatc ctcaatacta tacacttcca gctacaccac   1740

cacctaacag ggactttaaa aagaatacaa agtatggtat gccttctcag tgccttgtta   1800

gtaattcagt tacagttctg ccgaactttc tttaaaggaa tacaattctc aatcttacac   1860

cgttcagagc acaagcatag cttattgtat acaagagatg tgcatcagtt cccactcctc   1920

agggactgta tgaatttggc ttttttttga cggagtctca ctctgtcacc gggctggagt   1980

gcagtagtgt gatcttggct cactggactc tgcctcccgg gttcaagtga ttctcctgcc   2040

tcagcctccc aagtagctgg gactacaggt gcacaccact atgcccagct gattttttgt   2100

gtgtttttag tagagatggg gtttcaccat gttggccagg atggtcttga tctcttgacc   2160

tcatgatcta cccgctttgg cctcccaagg tgctgggatt acaggcatga ggcactgtgc   2220

tgggccaaat ttggttttct tgtggcatct gtgtttctct ttctgctctg tctctcccca   2280

tatcctagtc caaacatcca aagaaattaa ttacctccag gagatcgaga ccatcctggc   2340

taacacggtg aaaccccgtc tctactaaaa atacaaaaaa ttagccgggc atggtggcgg   2400

gcgcctgtag tcccagctac ttaggaggct gaggcaggag aatggcgtga acccgggagg   2460

cagagcttgc agtgagccga gatcgcgcca ttgcactcca gcctgggcga cagagcaaga   2520

ctctgtctc                                                           2529


<210>  8176
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  8176

Met Arg His Cys Ala Gly Pro Asn Leu Val Phe Leu Trp His Leu Cys 
1               5                   10                  15      


Phe Ser Phe Cys Ser Val Ser Pro His Ile Leu Val Gln Thr Ser Lys 
            20                  25                  30          


Glu Ile Asn Tyr Leu Gln Glu Ile Glu Thr Ile Leu Ala Asn Thr Val 
        35                  40                  45              


Lys Pro Arg Leu Tyr 
    50              


<210>  8177
<211>  4401
<212>  DNA
<213>  Homosapiens

<400>  8177
gcgcggccgg cccctggcct tcctcccctt cctgctccgg gcccgccagt agccggccgc     60

ggcggcgagg gactaggacg cggctggagc ggcgccggga gacgaggggc tgagagacgg    120

cggcggccga aagcggagag atgctgggcg tggcggccgg gatgacccac agcaacatgg    180

ccaacgccct ggccagcgcc acttgcgagc gctgcaaggg cggctttgcg cccgctgaga    240

agatcgtgaa cagtaatggg gagctgtacc atgagcagtg tttcgtgtgc gctcagtgct    300

tccagcagtt cccagaagga ctcttctatg agtttgaagg aagaaagtac tgtgaacatg    360

actttcagat gctctttgcc ccttgctgtc atcagtgtgg tgaattcatc attggccgag    420

ttatcaaagc catgaataac agctggcatc cggagtgctt ccgctgtgac ctctgccagg    480

aagttctggc agatatcggg tttgtcaaga atgctgggag acacctgtgt cgcccctgtc    540

ataatcgtga gaaagccaga ggccttggga aatacatctg ccagaaatgc catgctatca    600

tcgatgagca gcctctgata ttcaagaacg acccctacca tccagaccat ttcaactgcg    660

ccaactgcgg gaaggagctg actgccgatg cacgggagct gaaaggggag ctatactgcc    720

tcccatgcca tgataaaatg ggggtcccca tctgtggtgc ttgccgacgg cccatcgaag    780

ggcgcgtggt gaacgctatg ggcaagcagt ggcatgtgga gcattttgtt tgtgccaagt    840

gtgagaaacc ctttcttgga catcgccatt atgagaggaa aggcctggca tattgtgaaa    900

ctcactataa ccagctattt ggtgatgttt gcttccactg caatcgtgtt atagaaggtg    960

atgtggtctc tgctcttaat aaggcctggt gcgtgaactg ctttgcctgt tctacctgca   1020

acactaaatt aacactcaag aataagtttg tggagtttga catgaagcca gtctgtaaga   1080

agtgctatga gaaatttcca ttggagctga agaaaagact taagaaacta gctgagacct   1140

taggaaggaa ataagttcct ttattttttc ttttctatgc aagataagag attaccaaca   1200

ttacttgtct tgatctaccc atatttaaag ctatatctca aagcagttga gagaagagga   1260

cctatatgaa tggttttatg tcattttttt aattaaaaaa gaaaaattca tataatcgtg   1320

tttaaaacac aaatgaagtc agtatttgcc tttgttaacc cttatccatt tgttgacatg   1380

tagactgttt acaaaaaaaa aacacatggt taaatgttaa attttaatta aggcccccaa   1440

aaattaaata taacttttta aaatgaaagg agtcaccttt tacatgactc aggtgaaaaa   1500

acagtataaa cattaattta ctttgtgttc aaaagaaaat tccaactgct gttggggaag   1560

gacacagaaa agaaaaataa ccacccaaga aaaacaaaaa caagaaaaac aaatcttata   1620

caatcttagt atatttatca aactagtagc tagaaagtga atatgcacat tactaagaca   1680

aaaaacaagt gtaattcaga actacttgat tttttttagt taaatgcaat aattattatg   1740

cttagtttta taacctgctc tccttgtgaa ttcttccttc aaatgattac ttaacgcagt   1800

agtaatagct agctgtagga tgtcctttaa atttttgtgc aaaaaaaaat ttataccagg   1860

tatttggaaa tatactttac aatattggaa aatgaagtat ttttaatgta ttacagcaat   1920

tatgtttcta agcttaatgt taagcatgta gtcttagaat aggacatgaa attaaattgt   1980

atgtagcttg gaatatattg cttcagaaaa ctgaatgtgt atgtcggtca tattgccttt   2040

ataaccatgc taatatctat gctttataca tactcaaact tgccttgcct taaaaacata   2100

catactacat acttaaatca ggaattctag ccatctcaca gaataccaac taaaactaag   2160

tgcattgaga tctgagattg gtaaacccag attcatttac cacagctgta attaagtttt   2220

tagaaactat tctctttttg gggaaatcca ttgaagttaa tttctgttat cttattagaa   2280

gaaaatgatg ttgatatgtg tttcagattt tccatttgaa atcttataat taatttgatt   2340

tatttactgt aagtaggagg tataaatgac actcttaaat tggaaggagg ggtgttttag   2400

tgtctgtttt aggtcaaaat tagtgattct atttttatca aaagttttat cctgaagttt   2460

caggaccact cttccttaat aaacttgtta atggaaagcg agctttatga acatttaaaa   2520

atgttgctgc tgctttgttg cttaaaaaga aagttgccaa gagagacttc ttagggaaaa   2580

tatttgggtt ttttttccaa aaattgctga aatattgttt tgccattttt aaaaagtctc   2640

aggttattac cactctgcca ttaaatattt gtatgcctgc atttttaaaa attctgtgca   2700

tgtactttat ggagtacatt ctatttttgt tttcagatac cctacaacca atttttttta   2760

gtaatctttt agaattgaaa ttatcataaa tgatcgagaa taatcatcac atagtttaag   2820

attgtatatg ttgagtagtt taaaacaatc tttgcatttt acagtaagaa tcaaagtccc   2880

ttcagtgtgc ctttgtcagc taatatgtga ccagcaatga caaccttggg agtatttatt   2940

aaatattatg ctatgaatat aggcaacaca gaacagggtt tgcagtatag cgtcttgatg   3000

ctaaattctc atatacctct acacgagaaa tatggaggag aaaaacaagc atttacatat   3060

attcttcgtc actttgaaga tgcatggcct gaactcgact gcttgtgttt gtttacatat   3120

caggcatacc caggcatctc ctgcagccag aggttccatt gctgtctttg ctcagtcctc   3180

ttttaaaata tgaattagtg gacaggcacg gtgcctcaca cctgtaatcc cagcactttg   3240

ggaggtcgag gcaggtggat cacgaggtca ggagatcaag accatcctgg ctaccactga   3300

aaccccatct ctactacaaa aaaattagcc gggcgtggtg gcgggcacct gcagtcccag   3360

ctactcggga ggctgaggca ggagaatggt gggaacccgg gaggcagagc ttgcagtgag   3420

ccaagatcac gccactgcac tccagcctgg gcaacagagc aagactctgt ctcaaaaaaa   3480

ataaataaat aaattatgaa tgagtatttt ctagaaattc aacttgctaa gcctgtaata   3540

cttaagggta gtttatctag atacagtact ttcttccctg ataagtagta tcattggagc   3600

ccttaggtat aggagaagag gaagaagttt aaaaagtgta agtgggccgg gcgtggtggc   3660

tcatgcctgt aatcccagca ctttgggagg ccgagggggg cggatcacga ggtcaggaga   3720

tccagactat cctggctaac aaggtgaaac cccgtctcta ctaaaaatac aaaaaaaaac   3780

attagccagg cgtggtggcg ggcgcttgta gtcccagcta ctcgggaggc tgaggtagga   3840

gaatggcttg aacccaggag gcggagcttg cagtgagccg agattgcacc actgcactcc   3900

agcctgggcg acagagcaag actccgtctc aaaaaaaaaa aaaaagtgta agtggattaa   3960

aagagaaact tggtctagtt cataatattt ttaatagggc tttccctggc tgctggaaaa   4020

cttaggccag taagcatctc tttgtttaaa gtcctacaag acaatttgaa ataattcatt   4080

gttcatgcca aaattctaag tactgttttt cttagcaagt gtaacataat caggaacaat   4140

gggtacaagt aaaacattct ttggatgata ttcaaagcct tattagcact gcacctgaat   4200

aataggtcat tttgcctcac tcatttgcca aagtagccat ttctaagtta aggaagtttt   4260

tagataggct catagccttg tatttcgttt tagattgtaa gctcaatggc agggatacta   4320

tattggtaat tatgttttca tatagcaacc accacagtat attcttggtg cttaataaat   4380

gtttataatt gttaacaata a                                             4401


<210>  8178
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  8178

Met Leu Gly Val Ala Ala Gly Met Thr His Ser Asn Met Ala Asn Ala 
1               5                   10                  15      


Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly Phe Ala Pro Ala 
            20                  25                  30          


Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His Glu Gln Cys Phe 
        35                  40                  45              


Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly Leu Phe Tyr Glu 
    50                  55                  60                  


Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln Met Leu Phe Ala 
65                  70                  75                  80  


Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly Arg Val Ile Lys 
                85                  90                  95      


Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg Cys Asp Leu Cys 
            100                 105                 110         


Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn Ala Gly Arg His 
        115                 120                 125             


Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg Gly Leu Gly Lys 
    130                 135                 140                 


Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu Gln Pro Leu Ile 
145                 150                 155                 160 


Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn Cys Ala Asn Cys 
                165                 170                 175     


Gly Lys Glu Leu Thr Ala Asp Ala Arg Glu Leu Lys Gly Glu Leu Tyr 
            180                 185                 190         


Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile Cys Gly Ala Cys 
        195                 200                 205             


Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Met Gly Lys Gln Trp 
    210                 215                 220                 


His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe Leu Gly 
225                 230                 235                 240 


His Arg His Tyr Glu Arg Lys Gly Leu Ala Tyr Cys Glu Thr His Tyr 
                245                 250                 255     


Asn Gln Leu Phe Gly Asp Val Cys Phe His Cys Asn Arg Val Ile Glu 
            260                 265                 270         


Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Asn Cys Phe 
        275                 280                 285             


Ala Cys Ser Thr Cys Asn Thr Lys Leu Thr Leu Lys Asn Lys Phe Val 
    290                 295                 300                 


Glu Phe Asp Met Lys Pro Val Cys Lys Lys Cys Tyr Glu Lys Phe Pro 
305                 310                 315                 320 


Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ala Glu Thr Leu Gly Arg 
                325                 330                 335     


Lys 
    


<210>  8179
<211>  422
<212>  DNA
<213>  Homosapiens

<400>  8179
tataaaacaa cttagcagga tatgagttat gacatttagg ggtgttgtcc tattgcttca     60

gaacagtggg gttatcgtgt aacacaccat gtcacatgat ttgactaaat acaggaaaaa    120

aaaaaaccct gaacttggtt tcattggctc aaatatagtt caagacaaca gagacaaagc    180

taagatgagg aagttctgta cagtttagga aatagaggct ttcaaagata attcgcataa    240

tgcttttggc attttattac attaattttt taaaacatta tttctgctgc ctagggtctt    300

tggtggggaa atgtactatt tagcaatatg tttagtgaac ttttgtcctg tcatggtaag    360

aagaaagcag ctataactaa gtaaggagtt actcttattc attaacatgt aaaacgctgt    420

tt                                                                   422


<210>  8180
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  8180

Met Ser His Asp Leu Thr Lys Tyr Arg Lys Lys Lys Asn Pro Glu Leu 
1               5                   10                  15      


Gly Phe Ile Gly Ser Asn Ile Val Gln Asp Asn Arg Asp Lys Ala Lys 
            20                  25                  30          


Met Arg Lys Phe Cys Thr Val 
        35                  


<210>  8181
<211>  4669
<212>  DNA
<213>  Homosapiens

<400>  8181
atttaggggt gttgtcctat tgcttcagaa cagtggggtt atcgtgtaac acaccatgtc     60

acatgatttg actaaataca ggaaaaaaaa aaaccctgaa cttggtttca ttggctcaaa    120

tatagttcaa gacaacagag acaaagctaa gatgaggaag ttctgtacag tttaggaaat    180

agaggctttc aaagataatt cgcagtgatg tgaaactggc ctcccaagcc ctgataagta    240

agttaaataa gagtaggagc caggagggag gttctttact cttgaattaa gagaagggga    300

gctggaggtg gctcaggtag agtgcgtagg tttgcagaac tgggcctgtg tgtgtaaagt    360

gactaaggca aaggagtgga agtttgagag aagtttaaga gaagaaatgg acatgattgc    420

ctaaatcagc caaacacagg caacatggcc aacgccctgg ccagcgccac ttgcgagcgc    480

tgcaagggcg gctttgcgcc cgctgagaag atcgtgaaca gtaatgggga gctgtaccat    540

gagcagtgtt tcgtgtgcgc tcagtgcttc cagcagttcc cagaaggact cttctatgag    600

tttgaaggaa gaaagtactg tgaacatgac tttcagatgc tctttgcccc ttgctgtcat    660

cagtgtggtg aattcatcat tggccgagtt atcaaagcca tgaataacag ctggcatccg    720

gagtgcttcc gctgtgacct ctgccaggaa gttctggcag atatcgggtt tgtcaagaat    780

gctgggagac acctgtgtcg cccctgtcat aatcgtgaga aagccagagg ccttgggaaa    840

tacatctgcc agaaatgcca tgctatcatc gatgagcagc ctctgatatt caagaacgac    900

ccctaccatc cagaccattt caactgcgcc aactgcggga aggagctgac tgccgatgca    960

cgggagctga aaggggagct atactgcctc ccatgccatg ataaaatggg ggtccccatc   1020

tgtggtgctt gccgacggcc catcgaaggg cgcgtggtga acgctatggg caagcagtgg   1080

catgtggagc attttgtttg tgccaagtgt gagaaaccct ttcttggaca tcgccattat   1140

gagaggaaag gcctggcata ttgtgaaact cactataacc agctatttgg tgatgtttgc   1200

ttccactgca atcgtgttat agaaggtgat gtggtctctg ctcttaataa ggcctggtgc   1260

gtgaactgct ttgcctgttc tacctgcaac actaaattaa cactcaagaa taagtttgtg   1320

gagtttgaca tgaagccagt ctgtaagaag tgctatgaga aatttccatt ggagctgaag   1380

aaaagactta agaaactagc tgagacctta ggaaggaaat aagttccttt attttttctt   1440

ttctatgcaa gataagagat taccaacatt acttgtcttg atctacccat atttaaagct   1500

atatctcaaa gcagttgaga gaagaggacc tatatgaatg gttttatgtc atttttttaa   1560

ttaaaaaaga aaaattcata taatcgtgtt taaaacacaa atgaagtcag tatttgcctt   1620

tgttaaccct tatccatttg ttgacatgta gactgtttac aaaaaaaaaa cacatggtta   1680

aatgttaaat tttaattaag gcccccaaaa attaaatata actttttaaa atgaaaggag   1740

tcacctttta catgactcag gtgaaaaaac agtataaaca ttaatttact ttgtgttcaa   1800

aagaaaattc caactgctgt tggggaagga cacagaaaag aaaaataacc acccaagaaa   1860

aacaaaaaca agaaaaacaa atcttataca atcttagtat atttatcaaa ctagtagcta   1920

gaaagtgaat atgcacatta ctaagacaaa aaacaagtgt aattcagaac tacttgattt   1980

tttttagtta aatgcaataa ttattatgct tagttttata acctgctctc cttgtgaatt   2040

cttccttcaa atgattactt aacgcagtag taatagctag ctgtaggatg tcctttaaat   2100

ttttgtgcaa aaaaaaattt ataccaggta tttggaaata tactttacaa tattggaaaa   2160

tgaagtattt ttaatgtatt acagcaatta tgtttctaag cttaatgtta agcatgtagt   2220

cttagaatag gacatgaaat taaattgtat gtagcttgga atatattgct tcagaaaact   2280

gaatgtgtat gtcggtcata ttgcctttat aaccatgcta atatctatgc tttatacata   2340

ctcaaacttg ccttgcctta aaaacataca tactacatac ttaaatcagg aattctagcc   2400

atctcacaga ataccaacta aaactaagtg cattgagatc tgagattggt aaacccagat   2460

tcatttacca cagctgtaat taagttttta gaaactattc tctttttggg gaaatccatt   2520

gaagttaatt tctgttatct tattagaaga aaatgatgtt gatatgtgtt tcagattttc   2580

catttgaaat cttataatta atttgattta tttactgtaa gtaggaggta taaatgacac   2640

tcttaaattg gaaggagggg tgttttagtg tctgttttag gtcaaaatta gtgattctat   2700

ttttatcaaa agttttatcc tgaagtttca ggaccactct tccttaataa acttgttaat   2760

ggaaagcgag ctttatgaac atttaaaaat gttgctgctg ctttgttgct taaaaagaaa   2820

gttgccaaga gagacttctt agggaaaata tttgggtttt ttttccaaaa attgctgaaa   2880

tattgttttg ccatttttaa aaagtctcag gttattacca ctctgccatt aaatatttgt   2940

atgcctgcat ttttaaaaat tctgtgcatg tactttatgg agtacattct atttttgttt   3000

tcagataccc tacaaccaat tttttttagt aatcttttag aattgaaatt atcataaatg   3060

atcgagaata atcatcacat agtttaagat tgtatatgtt gagtagttta aaacaatctt   3120

tgcattttac agtaagaatc aaagtccctt cagtgtgcct ttgtcagcta atatgtgacc   3180

agcaatgaca accttgggag tatttattaa atattatgct atgaatatag gcaacacaga   3240

acagggtttg cagtatagcg tcttgatgct aaattctcat atacctctac acgagaaata   3300

tggaggagaa aaacaagcat ttacatatat tcttcgtcac tttgaagatg catggcctga   3360

actcgactgc ttgtgtttgt ttacatatca ggcataccca ggcatctcct gcagccagag   3420

gttccattgc tgtctttgct cagtcctctt ttaaaatatg aattagtgga caggcacggt   3480

gcctcacacc tgtaatccca gcactttggg aggtcgaggc aggtggatca cgaggtcagg   3540

agatcaagac catcctggct accactgaaa ccccatctct actacaaaaa aattagccgg   3600

gcgtggtggc gggcacctgc agtcccagct actcgggagg ctgaggcagg agaatggtgg   3660

gaacccggga ggcagagctt gcagtgagcc aagatcacgc cactgcactc cagcctgggc   3720

aacagagcaa gactctgtct caaaaaaaat aaataaataa attatgaatg agtattttct   3780

agaaattcaa cttgctaagc ctgtaatact taagggtagt ttatctagat acagtacttt   3840

cttccctgat aagtagtatc attggagccc ttaggtatag gagaagagga agaagtttaa   3900

aaagtgtaag tgggccgggc gtggtggctc atgcctgtaa tcccagcact ttgggaggcc   3960

gaggggggcg gatcacgagg tcaggagatc cagactatcc tggctaacaa ggtgaaaccc   4020

cgtctctact aaaaatacaa aaaaaaacat tagccaggcg tggtggcggg cgcttgtagt   4080

cccagctact cgggaggctg aggtaggaga atggcttgaa cccaggaggc ggagcttgca   4140

gtgagccgag attgcaccac tgcactccag cctgggcgac agagcaagac tccgtctcaa   4200

aaaaaaaaaa aaagtgtaag tggattaaaa gagaaacttg gtctagttca taatattttt   4260

aatagggctt tccctggctg ctggaaaact taggccagta agcatctctt tgtttaaagt   4320

cctacaagac aatttgaaat aattcattgt tcatgccaaa attctaagta ctgtttttct   4380

tagcaagtgt aacataatca ggaacaatgg gtacaagtaa aacattcttt ggatgatatt   4440

caaagcctta ttagcactgc acctgaataa taggtcattt tgcctcactc atttgccaaa   4500

gtagccattt ctaagttaag gaagttttta gataggctca tagccttgta tttcgtttta   4560

gattgtaagc tcaatggcag ggatactata ttggtaatta tgttttcata tagcaaccac   4620

cacagtatat tcttggtgct taataaatgt ttataattgt taacaataa               4669


<210>  8182
<211>  325
<212>  PRT
<213>  Homosapiens

<400>  8182

Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
1               5                   10                  15      


Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
    50                  55                  60                  


Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly 
65                  70                  75                  80  


Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg 
                85                  90                  95      


Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn 
            100                 105                 110         


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg 
        115                 120                 125             


Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu 
    130                 135                 140                 


Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn 
145                 150                 155                 160 


Cys Ala Asn Cys Gly Lys Glu Leu Thr Ala Asp Ala Arg Glu Leu Lys 
                165                 170                 175     


Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile 
            180                 185                 190         


Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Met 
        195                 200                 205             


Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys 
    210                 215                 220                 


Pro Phe Leu Gly His Arg His Tyr Glu Arg Lys Gly Leu Ala Tyr Cys 
225                 230                 235                 240 


Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Phe His Cys Asn 
                245                 250                 255     


Arg Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys 
            260                 265                 270         


Val Asn Cys Phe Ala Cys Ser Thr Cys Asn Thr Lys Leu Thr Leu Lys 
        275                 280                 285             


Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Lys Cys Tyr 
    290                 295                 300                 


Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ala Glu 
305                 310                 315                 320 


Thr Leu Gly Arg Lys 
                325 


<210>  8183
<211>  1283
<212>  DNA
<213>  Homosapiens

<400>  8183
ggctcaaata tagttcaaga caacagagac aaagctaaga tgaggaagtt ctgtacagtt     60

taggaaatag aggctttcaa agataattcg cagtgatgtg aaactggcct cccaagccct    120

gataacaaca tggccaacgc cctggccagc gccacttgcg agcgctgcaa gggcggcttt    180

gcgcccgctg agaagatcgt gaacagtaat ggggagctgt accatgagca gtgtttcgtg    240

tgcgctcagt gcttccagca gttcccagaa ggactcttct atgagtttga aggaagaaag    300

tactgtgaac atgactttca gatgctcttt gccccttgct gtcatcagtg tggtgaattc    360

atcattggcc gagttatcaa agccatgaat aacagctggc atccggagtg cttccgctgt    420

gacctctgcc aggaagttct ggcagatatc gggtttgtca agaatgctgg gagacacctg    480

tgtcgcccct gtcataatcg tgagaaagcc agaggccttg ggaaatacat ctgccagaaa    540

tgccatgcta tcatcgatga gcagcctctg atattcaaga acgaccccta ccatccagac    600

catttcaact gcgccaactg cgggaaggag ctgactgccg atgcacggga gctgaaaggg    660

gagctatact gcctcccatg ccatgataaa atgggggtcc ccatctgtgg tgcttgccga    720

cggcccatcg aagggcgcgt ggtgaacgct atgggcaagc agtggcatgt ggagcatttt    780

gtttgtgcca agtgtgagaa accctttctt ggacatcgcc attatgagag gaaaggcctg    840

gcatattgtg aaactcacta taaccagcta tttggtgatg tttgcttcca ctgcaatcgt    900

gttatagaag gtgatgtggt ctctgctctt aataaggcct ggtgcgtgaa ctgctttgcc    960

tgttctacct gcaacactaa attaacactc aagaataagt ttgtggagtt tgacatgaag   1020

ccagtctgta agaagtgcta tgagaaattt ccattggagc tgaagaaaag acttaagaaa   1080

ctagctgaga ccttaggaag gaaataagtt cctttatttt ttcttttcta tgcaagataa   1140

gagattacca acattacttg tcttgatcta cccatattta aagctatatc tcaaagcagt   1200

tgagagaaga ggacctatat gaatggtttt atgtcatttt tttaattaaa aaagaaaaat   1260

tcatataatc gtgtttaaaa cac                                           1283


<210>  8184
<211>  325
<212>  PRT
<213>  Homosapiens

<400>  8184

Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
1               5                   10                  15      


Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
    50                  55                  60                  


Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly 
65                  70                  75                  80  


Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg 
                85                  90                  95      


Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn 
            100                 105                 110         


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg 
        115                 120                 125             


Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu 
    130                 135                 140                 


Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn 
145                 150                 155                 160 


Cys Ala Asn Cys Gly Lys Glu Leu Thr Ala Asp Ala Arg Glu Leu Lys 
                165                 170                 175     


Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile 
            180                 185                 190         


Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Met 
        195                 200                 205             


Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys 
    210                 215                 220                 


Pro Phe Leu Gly His Arg His Tyr Glu Arg Lys Gly Leu Ala Tyr Cys 
225                 230                 235                 240 


Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Phe His Cys Asn 
                245                 250                 255     


Arg Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys 
            260                 265                 270         


Val Asn Cys Phe Ala Cys Ser Thr Cys Asn Thr Lys Leu Thr Leu Lys 
        275                 280                 285             


Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Lys Cys Tyr 
    290                 295                 300                 


Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ala Glu 
305                 310                 315                 320 


Thr Leu Gly Arg Lys 
                325 


<210>  8185
<211>  4354
<212>  DNA
<213>  Homosapiens

<400>  8185
ggctcaaata tagttcaaga caacagagac aaagctaaga tgaggaagtt ctgtacagtt     60

taggaaatag aggctttcaa agataattcg cagtgatgtg aaactggcct cccaagccct    120

gataacaaca tggccaacgc cctggccagc gccacttgcg agcgctgcaa gggcggcttt    180

gcgcccgctg agaagatcgt gaacagtaat ggggagctgt accatgagca gtgtttcgtg    240

tgcgctcagt gcttccagca gttcccagaa ggactcttct atgagtttga aggaagaaag    300

tactgtgaac atgactttca gatgctcttt gccccttgct gtcatcagtg tggtgaattc    360

atcattggcc gagttatcaa agccatgaat aacagctggc atccggagtg cttccgctgt    420

gacctctgcc aggaagttct ggcagatatc gggtttgtca agaatgctgg gagacacctg    480

tgtcgcccct gtcataatcg tgagaaagcc agaggccttg ggaaatacat ctgccagaaa    540

tgccatgcta tcatcgatga gcagcctctg atattcaaga acgaccccta ccatccagac    600

catttcaact gcgccaactg cgggaaggag ctgactgccg atgcacggga gctgaaaggg    660

gagctatact gcctcccatg ccatgataaa atgggggtcc ccatctgtgg tgcttgccga    720

cggcccatcg aagggcgcgt ggtgaacgct atgggcaagc agtggcatgt ggagcatttt    780

gtttgtgcca agtgtgagaa accctttctt ggacatcgcc attatgagag gaaaggcctg    840

gcatattgtg aaactcacta taaccagcta tttggtgatg tttgcttcca ctgcaatcgt    900

gttatagaag gtgatgtggt ctctgctctt aataaggcct ggtgcgtgaa ctgctttgcc    960

tgttctacct gcaacactaa attaacactc aagaataagt ttgtggagtt tgacatgaag   1020

ccagtctgta agaagtgcta tgagaaattt ccattggagc tgaagaaaag acttaagaaa   1080

ctagctgaga ccttaggaag gaaataagtt cctttatttt ttcttttcta tgcaagataa   1140

gagattacca acattacttg tcttgatcta cccatattta aagctatatc tcaaagcagt   1200

tgagagaaga ggacctatat gaatggtttt atgtcatttt tttaattaaa aaagaaaaat   1260

tcatataatc gtgtttaaaa cacaaatgaa gtcagtattt gcctttgtta acccttatcc   1320

atttgttgac atgtagactg tttacaaaaa aaaaacacat ggttaaatgt taaattttaa   1380

ttaaggcccc caaaaattaa atataacttt ttaaaatgaa aggagtcacc ttttacatga   1440

ctcaggtgaa aaaacagtat aaacattaat ttactttgtg ttcaaaagaa aattccaact   1500

gctgttgggg aaggacacag aaaagaaaaa taaccaccca agaaaaacaa aaacaagaaa   1560

aacaaatctt atacaatctt agtatattta tcaaactagt agctagaaag tgaatatgca   1620

cattactaag acaaaaaaca agtgtaattc agaactactt gatttttttt agttaaatgc   1680

aataattatt atgcttagtt ttataacctg ctctccttgt gaattcttcc ttcaaatgat   1740

tacttaacgc agtagtaata gctagctgta ggatgtcctt taaatttttg tgcaaaaaaa   1800

aatttatacc aggtatttgg aaatatactt tacaatattg gaaaatgaag tatttttaat   1860

gtattacagc aattatgttt ctaagcttaa tgttaagcat gtagtcttag aataggacat   1920

gaaattaaat tgtatgtagc ttggaatata ttgcttcaga aaactgaatg tgtatgtcgg   1980

tcatattgcc tttataacca tgctaatatc tatgctttat acatactcaa acttgccttg   2040

ccttaaaaac atacatacta catacttaaa tcaggaattc tagccatctc acagaatacc   2100

aactaaaact aagtgcattg agatctgaga ttggtaaacc cagattcatt taccacagct   2160

gtaattaagt ttttagaaac tattctcttt ttggggaaat ccattgaagt taatttctgt   2220

tatcttatta gaagaaaatg atgttgatat gtgtttcaga ttttccattt gaaatcttat   2280

aattaatttg atttatttac tgtaagtagg aggtataaat gacactctta aattggaagg   2340

aggggtgttt tagtgtctgt tttaggtcaa aattagtgat tctattttta tcaaaagttt   2400

tatcctgaag tttcaggacc actcttcctt aataaacttg ttaatggaaa gcgagcttta   2460

tgaacattta aaaatgttgc tgctgctttg ttgcttaaaa agaaagttgc caagagagac   2520

ttcttaggga aaatatttgg gttttttttc caaaaattgc tgaaatattg ttttgccatt   2580

tttaaaaagt ctcaggttat taccactctg ccattaaata tttgtatgcc tgcattttta   2640

aaaattctgt gcatgtactt tatggagtac attctatttt tgttttcaga taccctacaa   2700

ccaatttttt ttagtaatct tttagaattg aaattatcat aaatgatcga gaataatcat   2760

cacatagttt aagattgtat atgttgagta gtttaaaaca atctttgcat tttacagtaa   2820

gaatcaaagt cccttcagtg tgcctttgtc agctaatatg tgaccagcaa tgacaacctt   2880

gggagtattt attaaatatt atgctatgaa tataggcaac acagaacagg gtttgcagta   2940

tagcgtcttg atgctaaatt ctcatatacc tctacacgag aaatatggag gagaaaaaca   3000

agcatttaca tatattcttc gtcactttga agatgcatgg cctgaactcg actgcttgtg   3060

tttgtttaca tatcaggcat acccaggcat ctcctgcagc cagaggttcc attgctgtct   3120

ttgctcagtc ctcttttaaa atatgaatta gtggacaggc acggtgcctc acacctgtaa   3180

tcccagcact ttgggaggtc gaggcaggtg gatcacgagg tcaggagatc aagaccatcc   3240

tggctaccac tgaaacccca tctctactac aaaaaaatta gccgggcgtg gtggcgggca   3300

cctgcagtcc cagctactcg ggaggctgag gcaggagaat ggtgggaacc cgggaggcag   3360

agcttgcagt gagccaagat cacgccactg cactccagcc tgggcaacag agcaagactc   3420

tgtctcaaaa aaaataaata aataaattat gaatgagtat tttctagaaa ttcaacttgc   3480

taagcctgta atacttaagg gtagtttatc tagatacagt actttcttcc ctgataagta   3540

gtatcattgg agcccttagg tataggagaa gaggaagaag tttaaaaagt gtaagtgggc   3600

cgggcgtggt ggctcatgcc tgtaatccca gcactttggg aggccgaggg gggcggatca   3660

cgaggtcagg agatccagac tatcctggct aacaaggtga aaccccgtct ctactaaaaa   3720

tacaaaaaaa aacattagcc aggcgtggtg gcgggcgctt gtagtcccag ctactcggga   3780

ggctgaggta ggagaatggc ttgaacccag gaggcggagc ttgcagtgag ccgagattgc   3840

accactgcac tccagcctgg gcgacagagc aagactccgt ctcaaaaaaa aaaaaaaagt   3900

gtaagtggat taaaagagaa acttggtcta gttcataata tttttaatag ggctttccct   3960

ggctgctgga aaacttaggc cagtaagcat ctctttgttt aaagtcctac aagacaattt   4020

gaaataattc attgttcatg ccaaaattct aagtactgtt tttcttagca agtgtaacat   4080

aatcaggaac aatgggtaca agtaaaacat tctttggatg atattcaaag ccttattagc   4140

actgcacctg aataataggt cattttgcct cactcatttg ccaaagtagc catttctaag   4200

ttaaggaagt ttttagatag gctcatagcc ttgtatttcg ttttagattg taagctcaat   4260

ggcagggata ctatattggt aattatgttt tcatatagca accaccacag tatattcttg   4320

gtgcttaata aatgtttata attgttaaca ataa                               4354


<210>  8186
<211>  325
<212>  PRT
<213>  Homosapiens

<400>  8186

Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
1               5                   10                  15      


Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
    50                  55                  60                  


Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly 
65                  70                  75                  80  


Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg 
                85                  90                  95      


Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn 
            100                 105                 110         


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg 
        115                 120                 125             


Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu 
    130                 135                 140                 


Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn 
145                 150                 155                 160 


Cys Ala Asn Cys Gly Lys Glu Leu Thr Ala Asp Ala Arg Glu Leu Lys 
                165                 170                 175     


Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile 
            180                 185                 190         


Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Met 
        195                 200                 205             


Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys 
    210                 215                 220                 


Pro Phe Leu Gly His Arg His Tyr Glu Arg Lys Gly Leu Ala Tyr Cys 
225                 230                 235                 240 


Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Phe His Cys Asn 
                245                 250                 255     


Arg Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys 
            260                 265                 270         


Val Asn Cys Phe Ala Cys Ser Thr Cys Asn Thr Lys Leu Thr Leu Lys 
        275                 280                 285             


Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Lys Cys Tyr 
    290                 295                 300                 


Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ala Glu 
305                 310                 315                 320 


Thr Leu Gly Arg Lys 
                325 


<210>  8187
<211>  660
<212>  DNA
<213>  Homosapiens

<400>  8187
gaggaagttc tgtacagttt aggaaataga ggctttcaaa gataattcgc agtgatgtga     60

aactggcctc ccaagccctg ataacaacat ggccaacgcc ctggccagcg ccacttgcga    120

gcgctgcaag ggcggctttg cgcccgctga gaagatcgtg aacagtaatg gggagctgta    180

ccatgagcag tgtttcgtgt gcgctcagtg cttccagcag ttcccagaag gactcttcta    240

tgagggacct gaggacctac ttctacctcg gcaccatgga ggcctgcggg gactatggca    300

aggaaggagg tgagactccc aaggcacatt gaagggaatt ctggaaagct ggcttggaga    360

gagcatggtc ttctcactat atgaatccct tctgtatccc tcccttcttt tttttctctc    420

ctgtagtcca gagaggttga aatgtctgat aacatagcag gtttgcgaca tgaaagagat    480

gagagcctag ctggtctcct agtatctaat acaatattct ttcccttaca tattcttttt    540

aaatataaga tatttttatt gaaatgggca attatgacaa aggccttagg agagctcggt    600

ccaggggagc aatagagaag aactcagaga aaaagacagg ctttgttttt ccagacattt    660


<210>  8188
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  8188

Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
1               5                   10                  15      


Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Gly Pro Glu Asp Leu Leu Leu Pro Arg His His Gly 
    50                  55                  60                  


Gly Leu Arg Gly Leu Trp Gln Gly Arg Arg 
65                  70                  


<210>  8189
<211>  816
<212>  DNA
<213>  Homosapiens

<400>  8189
aggaagttct gtacagttta ggaaatagag gctttcaaag ataattcgca gtgatgtgaa     60

actggcctcc caagccctga taacaacatg gccaacgccc tggccagcgc cacttgcgag    120

cgctgcaagg gcggctttgc gcccgctgag aagatcgtga acagtaatgg ggagctgtac    180

catgagcagt gtttcgtgtg cgctcagtgc ttccagcagt tcccagaagg actcttctat    240

gaggaacgaa catgatggtt aagctacctt cattaagcag catgaccgct tcctgagctc    300

ctgctgccgc atttaggccc tgtcagctgt gaggccactg gtgctgagtc agagggaaaa    360

gctcagaaca gccttgagca gtgaagaata aagtgtgact catctcgtcc tgcccacccc    420

tcacactgga ctataaatac cctccctggg tctgtgtgct gttattccaa aagatgcgat    480

gaatacccag aactaggcta ttcatgggct gttgcccagt tcaagatctg ttgggtcctg    540

aggaagatta ctattttggc taaattgttt atcattaaaa ccagcccagg gatgtgtaaa    600

cctgcatctg gagaataaga catttctttt tggttaaatg atattagaga aaaaaactat    660

ccaagactgc taacaaataa tcttcacttt cagttatatc cagcaataag ttgttttcca    720

gaaaagaaag cttggaaact tacccagttt gccttccatt tgggacatga ctgatgtgct    780

tcagtctttg tataataaat gcatcttcgc cactct                              816


<210>  8190
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  8190

Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
1               5                   10                  15      


Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Glu Arg Thr 
    50                  55  


<210>  8191
<211>  4324
<212>  DNA
<213>  Homosapiens

<400>  8191
gaggacacag tgagagggtg ccatctatga gcatggagag cttagcttgg acagccagct     60

gatgagggac acatcgaatc aagatacatg acatgcaaca tggccaacgc cctggccagc    120

gccacttgcg agcgctgcaa gggcggcttt gcgcccgctg agaagatcgt gaacagtaat    180

ggggagctgt accatgagca gtgtttcgtg tgcgctcagt gcttccagca gttcccagaa    240

ggactcttct atgagtttga aggaagaaag tactgtgaac atgactttca gatgctcttt    300

gccccttgct gtcatcagtg tggtgaattc atcattggcc gagttatcaa agccatgaat    360

aacagctggc atccggagtg cttccgctgt gacctctgcc aggaagttct ggcagatatc    420

gggtttgtca agaatgctgg gagacacctg tgtcgcccct gtcataatcg tgagaaagcc    480

agaggccttg ggaaatacat ctgccagaaa tgccatgcta tcatcgatga gcagcctctg    540

atattcaaga acgaccccta ccatccagac catttcaact gcgccaactg cgggaaggag    600

ctgactgccg atgcacggga gctgaaaggg gagctatact gcctcccatg ccatgataaa    660

atgggggtcc ccatctgtgg tgcttgccga cggcccatcg aagggcgcgt ggtgaacgct    720

atgggcaagc agtggcatgt ggagcatttt gtttgtgcca agtgtgagaa accctttctt    780

ggacatcgcc attatgagag gaaaggcctg gcatattgtg aaactcacta taaccagcta    840

tttggtgatg tttgcttcca ctgcaatcgt gttatagaag gtgatgtggt ctctgctctt    900

aataaggcct ggtgcgtgaa ctgctttgcc tgttctacct gcaacactaa attaacactc    960

aagaataagt ttgtggagtt tgacatgaag ccagtctgta agaagtgcta tgagaaattt   1020

ccattggagc tgaagaaaag acttaagaaa ctagctgaga ccttaggaag gaaataagtt   1080

cctttatttt ttcttttcta tgcaagataa gagattacca acattacttg tcttgatcta   1140

cccatattta aagctatatc tcaaagcagt tgagagaaga ggacctatat gaatggtttt   1200

atgtcatttt tttaattaaa aaagaaaaat tcatataatc gtgtttaaaa cacaaatgaa   1260

gtcagtattt gcctttgtta acccttatcc atttgttgac atgtagactg tttacaaaaa   1320

aaaaacacat ggttaaatgt taaattttaa ttaaggcccc caaaaattaa atataacttt   1380

ttaaaatgaa aggagtcacc ttttacatga ctcaggtgaa aaaacagtat aaacattaat   1440

ttactttgtg ttcaaaagaa aattccaact gctgttgggg aaggacacag aaaagaaaaa   1500

taaccaccca agaaaaacaa aaacaagaaa aacaaatctt atacaatctt agtatattta   1560

tcaaactagt agctagaaag tgaatatgca cattactaag acaaaaaaca agtgtaattc   1620

agaactactt gatttttttt agttaaatgc aataattatt atgcttagtt ttataacctg   1680

ctctccttgt gaattcttcc ttcaaatgat tacttaacgc agtagtaata gctagctgta   1740

ggatgtcctt taaatttttg tgcaaaaaaa aatttatacc aggtatttgg aaatatactt   1800

tacaatattg gaaaatgaag tatttttaat gtattacagc aattatgttt ctaagcttaa   1860

tgttaagcat gtagtcttag aataggacat gaaattaaat tgtatgtagc ttggaatata   1920

ttgcttcaga aaactgaatg tgtatgtcgg tcatattgcc tttataacca tgctaatatc   1980

tatgctttat acatactcaa acttgccttg ccttaaaaac atacatacta catacttaaa   2040

tcaggaattc tagccatctc acagaatacc aactaaaact aagtgcattg agatctgaga   2100

ttggtaaacc cagattcatt taccacagct gtaattaagt ttttagaaac tattctcttt   2160

ttggggaaat ccattgaagt taatttctgt tatcttatta gaagaaaatg atgttgatat   2220

gtgtttcaga ttttccattt gaaatcttat aattaatttg atttatttac tgtaagtagg   2280

aggtataaat gacactctta aattggaagg aggggtgttt tagtgtctgt tttaggtcaa   2340

aattagtgat tctattttta tcaaaagttt tatcctgaag tttcaggacc actcttcctt   2400

aataaacttg ttaatggaaa gcgagcttta tgaacattta aaaatgttgc tgctgctttg   2460

ttgcttaaaa agaaagttgc caagagagac ttcttaggga aaatatttgg gttttttttc   2520

caaaaattgc tgaaatattg ttttgccatt tttaaaaagt ctcaggttat taccactctg   2580

ccattaaata tttgtatgcc tgcattttta aaaattctgt gcatgtactt tatggagtac   2640

attctatttt tgttttcaga taccctacaa ccaatttttt ttagtaatct tttagaattg   2700

aaattatcat aaatgatcga gaataatcat cacatagttt aagattgtat atgttgagta   2760

gtttaaaaca atctttgcat tttacagtaa gaatcaaagt cccttcagtg tgcctttgtc   2820

agctaatatg tgaccagcaa tgacaacctt gggagtattt attaaatatt atgctatgaa   2880

tataggcaac acagaacagg gtttgcagta tagcgtcttg atgctaaatt ctcatatacc   2940

tctacacgag aaatatggag gagaaaaaca agcatttaca tatattcttc gtcactttga   3000

agatgcatgg cctgaactcg actgcttgtg tttgtttaca tatcaggcat acccaggcat   3060

ctcctgcagc cagaggttcc attgctgtct ttgctcagtc ctcttttaaa atatgaatta   3120

gtggacaggc acggtgcctc acacctgtaa tcccagcact ttgggaggtc gaggcaggtg   3180

gatcacgagg tcaggagatc aagaccatcc tggctaccac tgaaacccca tctctactac   3240

aaaaaaatta gccgggcgtg gtggcgggca cctgcagtcc cagctactcg ggaggctgag   3300

gcaggagaat ggtgggaacc cgggaggcag agcttgcagt gagccaagat cacgccactg   3360

cactccagcc tgggcaacag agcaagactc tgtctcaaaa aaaataaata aataaattat   3420

gaatgagtat tttctagaaa ttcaacttgc taagcctgta atacttaagg gtagtttatc   3480

tagatacagt actttcttcc ctgataagta gtatcattgg agcccttagg tataggagaa   3540

gaggaagaag tttaaaaagt gtaagtgggc cgggcgtggt ggctcatgcc tgtaatccca   3600

gcactttggg aggccgaggg gggcggatca cgaggtcagg agatccagac tatcctggct   3660

aacaaggtga aaccccgtct ctactaaaaa tacaaaaaaa aacattagcc aggcgtggtg   3720

gcgggcgctt gtagtcccag ctactcggga ggctgaggta ggagaatggc ttgaacccag   3780

gaggcggagc ttgcagtgag ccgagattgc accactgcac tccagcctgg gcgacagagc   3840

aagactccgt ctcaaaaaaa aaaaaaaagt gtaagtggat taaaagagaa acttggtcta   3900

gttcataata tttttaatag ggctttccct ggctgctgga aaacttaggc cagtaagcat   3960

ctctttgttt aaagtcctac aagacaattt gaaataattc attgttcatg ccaaaattct   4020

aagtactgtt tttcttagca agtgtaacat aatcaggaac aatgggtaca agtaaaacat   4080

tctttggatg atattcaaag ccttattagc actgcacctg aataataggt cattttgcct   4140

cactcatttg ccaaagtagc catttctaag ttaaggaagt ttttagatag gctcatagcc   4200

ttgtatttcg ttttagattg taagctcaat ggcagggata ctatattggt aattatgttt   4260

tcatatagca accaccacag tatattcttg gtgcttaata aatgtttata attgttaaca   4320

ataa                                                                4324


<210>  8192
<211>  329
<212>  PRT
<213>  Homosapiens

<400>  8192

Met Thr Cys Asn Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg 
1               5                   10                  15      


Cys Lys Gly Gly Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly 
            20                  25                  30          


Glu Leu Tyr His Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln 
        35                  40                  45              


Phe Pro Glu Gly Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu 
    50                  55                  60                  


His Asp Phe Gln Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu 
65                  70                  75                  80  


Phe Ile Ile Gly Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro 
                85                  90                  95      


Glu Cys Phe Arg Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly 
            100                 105                 110         


Phe Val Lys Asn Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg 
        115                 120                 125             


Glu Lys Ala Arg Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His Ala 
    130                 135                 140                 


Ile Ile Asp Glu Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His Pro 
145                 150                 155                 160 


Asp His Phe Asn Cys Ala Asn Cys Gly Lys Glu Leu Thr Ala Asp Ala 
                165                 170                 175     


Arg Glu Leu Lys Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met 
            180                 185                 190         


Gly Val Pro Ile Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val 
        195                 200                 205             


Val Asn Ala Met Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala 
    210                 215                 220                 


Lys Cys Glu Lys Pro Phe Leu Gly His Arg His Tyr Glu Arg Lys Gly 
225                 230                 235                 240 


Leu Ala Tyr Cys Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys 
                245                 250                 255     


Phe His Cys Asn Arg Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn 
            260                 265                 270         


Lys Ala Trp Cys Val Asn Cys Phe Ala Cys Ser Thr Cys Asn Thr Lys 
        275                 280                 285             


Leu Thr Leu Lys Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys 
    290                 295                 300                 


Lys Lys Cys Tyr Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys 
305                 310                 315                 320 


Lys Leu Ala Glu Thr Leu Gly Arg Lys 
                325                 


<210>  8193
<211>  4425
<212>  DNA
<213>  Homosapiens

<400>  8193
cctcggcaag ggacgctgct ttcccctggc agccacactg ctgagcataa atgctttaaa     60

gtgtcagcaa ttgatgtgtg gagagaagta tgactgcatt acagcttaaa gagctttcac    120

attcaggtct ctacaggaga agacgagatc gccccgatag tttgagagta aatgggttac    180

cagaggaaga gctaagcaac atggccaacg ccctggccag cgccacttgc gagcgctgca    240

agggcggctt tgcgcccgct gagaagatcg tgaacagtaa tggggagctg taccatgagc    300

agtgtttcgt gtgcgctcag tgcttccagc agttcccaga aggactcttc tatgagtttg    360

aaggaagaaa gtactgtgaa catgactttc agatgctctt tgccccttgc tgtcatcagt    420

gtggtgaatt catcattggc cgagttatca aagccatgaa taacagctgg catccggagt    480

gcttccgctg tgacctctgc caggaagttc tggcagatat cgggtttgtc aagaatgctg    540

ggagacacct gtgtcgcccc tgtcataatc gtgagaaagc cagaggcctt gggaaataca    600

tctgccagaa atgccatgct atcatcgatg agcagcctct gatattcaag aacgacccct    660

accatccaga ccatttcaac tgcgccaact gcgggaagga gctgactgcc gatgcacggg    720

agctgaaagg ggagctatac tgcctcccat gccatgataa aatgggggtc cccatctgtg    780

gtgcttgccg acggcccatc gaagggcgcg tggtgaacgc tatgggcaag cagtggcatg    840

tggagcattt tgtttgtgcc aagtgtgaga aaccctttct tggacatcgc cattatgaga    900

ggaaaggcct ggcatattgt gaaactcact ataaccagct atttggtgat gtttgcttcc    960

actgcaatcg tgttatagaa ggtgatgtgg tctctgctct taataaggcc tggtgcgtga   1020

actgctttgc ctgttctacc tgcaacacta aattaacact caagaataag tttgtggagt   1080

ttgacatgaa gccagtctgt aagaagtgct atgagaaatt tccattggag ctgaagaaaa   1140

gacttaagaa actagctgag accttaggaa ggaaataagt tcctttattt tttcttttct   1200

atgcaagata agagattacc aacattactt gtcttgatct acccatattt aaagctatat   1260

ctcaaagcag ttgagagaag aggacctata tgaatggttt tatgtcattt ttttaattaa   1320

aaaagaaaaa ttcatataat cgtgtttaaa acacaaatga agtcagtatt tgcctttgtt   1380

aacccttatc catttgttga catgtagact gtttacaaaa aaaaaacaca tggttaaatg   1440

ttaaatttta attaaggccc ccaaaaatta aatataactt tttaaaatga aaggagtcac   1500

cttttacatg actcaggtga aaaaacagta taaacattaa tttactttgt gttcaaaaga   1560

aaattccaac tgctgttggg gaaggacaca gaaaagaaaa ataaccaccc aagaaaaaca   1620

aaaacaagaa aaacaaatct tatacaatct tagtatattt atcaaactag tagctagaaa   1680

gtgaatatgc acattactaa gacaaaaaac aagtgtaatt cagaactact tgattttttt   1740

tagttaaatg caataattat tatgcttagt tttataacct gctctccttg tgaattcttc   1800

cttcaaatga ttacttaacg cagtagtaat agctagctgt aggatgtcct ttaaattttt   1860

gtgcaaaaaa aaatttatac caggtatttg gaaatatact ttacaatatt ggaaaatgaa   1920

gtatttttaa tgtattacag caattatgtt tctaagctta atgttaagca tgtagtctta   1980

gaataggaca tgaaattaaa ttgtatgtag cttggaatat attgcttcag aaaactgaat   2040

gtgtatgtcg gtcatattgc ctttataacc atgctaatat ctatgcttta tacatactca   2100

aacttgcctt gccttaaaaa catacatact acatacttaa atcaggaatt ctagccatct   2160

cacagaatac caactaaaac taagtgcatt gagatctgag attggtaaac ccagattcat   2220

ttaccacagc tgtaattaag tttttagaaa ctattctctt tttggggaaa tccattgaag   2280

ttaatttctg ttatcttatt agaagaaaat gatgttgata tgtgtttcag attttccatt   2340

tgaaatctta taattaattt gatttattta ctgtaagtag gaggtataaa tgacactctt   2400

aaattggaag gaggggtgtt ttagtgtctg ttttaggtca aaattagtga ttctattttt   2460

atcaaaagtt ttatcctgaa gtttcaggac cactcttcct taataaactt gttaatggaa   2520

agcgagcttt atgaacattt aaaaatgttg ctgctgcttt gttgcttaaa aagaaagttg   2580

ccaagagaga cttcttaggg aaaatatttg ggtttttttt ccaaaaattg ctgaaatatt   2640

gttttgccat ttttaaaaag tctcaggtta ttaccactct gccattaaat atttgtatgc   2700

ctgcattttt aaaaattctg tgcatgtact ttatggagta cattctattt ttgttttcag   2760

ataccctaca accaattttt tttagtaatc ttttagaatt gaaattatca taaatgatcg   2820

agaataatca tcacatagtt taagattgta tatgttgagt agtttaaaac aatctttgca   2880

ttttacagta agaatcaaag tcccttcagt gtgcctttgt cagctaatat gtgaccagca   2940

atgacaacct tgggagtatt tattaaatat tatgctatga atataggcaa cacagaacag   3000

ggtttgcagt atagcgtctt gatgctaaat tctcatatac ctctacacga gaaatatgga   3060

ggagaaaaac aagcatttac atatattctt cgtcactttg aagatgcatg gcctgaactc   3120

gactgcttgt gtttgtttac atatcaggca tacccaggca tctcctgcag ccagaggttc   3180

cattgctgtc tttgctcagt cctcttttaa aatatgaatt agtggacagg cacggtgcct   3240

cacacctgta atcccagcac tttgggaggt cgaggcaggt ggatcacgag gtcaggagat   3300

caagaccatc ctggctacca ctgaaacccc atctctacta caaaaaaatt agccgggcgt   3360

ggtggcgggc acctgcagtc ccagctactc gggaggctga ggcaggagaa tggtgggaac   3420

ccgggaggca gagcttgcag tgagccaaga tcacgccact gcactccagc ctgggcaaca   3480

gagcaagact ctgtctcaaa aaaaataaat aaataaatta tgaatgagta ttttctagaa   3540

attcaacttg ctaagcctgt aatacttaag ggtagtttat ctagatacag tactttcttc   3600

cctgataagt agtatcattg gagcccttag gtataggaga agaggaagaa gtttaaaaag   3660

tgtaagtggg ccgggcgtgg tggctcatgc ctgtaatccc agcactttgg gaggccgagg   3720

ggggcggatc acgaggtcag gagatccaga ctatcctggc taacaaggtg aaaccccgtc   3780

tctactaaaa atacaaaaaa aaacattagc caggcgtggt ggcgggcgct tgtagtccca   3840

gctactcggg aggctgaggt aggagaatgg cttgaaccca ggaggcggag cttgcagtga   3900

gccgagattg caccactgca ctccagcctg ggcgacagag caagactccg tctcaaaaaa   3960

aaaaaaaaag tgtaagtgga ttaaaagaga aacttggtct agttcataat atttttaata   4020

gggctttccc tggctgctgg aaaacttagg ccagtaagca tctctttgtt taaagtccta   4080

caagacaatt tgaaataatt cattgttcat gccaaaattc taagtactgt ttttcttagc   4140

aagtgtaaca taatcaggaa caatgggtac aagtaaaaca ttctttggat gatattcaaa   4200

gccttattag cactgcacct gaataatagg tcattttgcc tcactcattt gccaaagtag   4260

ccatttctaa gttaaggaag tttttagata ggctcatagc cttgtatttc gttttagatt   4320

gtaagctcaa tggcagggat actatattgg taattatgtt ttcatatagc aaccaccaca   4380

gtatattctt ggtgcttaat aaatgtttat aattgttaac aataa                   4425


<210>  8194
<211>  362
<212>  PRT
<213>  Homosapiens

<400>  8194

Met Thr Ala Leu Gln Leu Lys Glu Leu Ser His Ser Gly Leu Tyr Arg 
1               5                   10                  15      


Arg Arg Arg Asp Arg Pro Asp Ser Leu Arg Val Asn Gly Leu Pro Glu 
            20                  25                  30          


Glu Glu Leu Ser Asn Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu 
        35                  40                  45              


Arg Cys Lys Gly Gly Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn 
    50                  55                  60                  


Gly Glu Leu Tyr His Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln 
65                  70                  75                  80  


Gln Phe Pro Glu Gly Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys 
                85                  90                  95      


Glu His Asp Phe Gln Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly 
            100                 105                 110         


Glu Phe Ile Ile Gly Arg Val Ile Lys Ala Met Asn Asn Ser Trp His 
        115                 120                 125             


Pro Glu Cys Phe Arg Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile 
    130                 135                 140                 


Gly Phe Val Lys Asn Ala Gly Arg His Leu Cys Arg Pro Cys His Asn 
145                 150                 155                 160 


Arg Glu Lys Ala Arg Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His 
                165                 170                 175     


Ala Ile Ile Asp Glu Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His 
            180                 185                 190         


Pro Asp His Phe Asn Cys Ala Asn Cys Gly Lys Glu Leu Thr Ala Asp 
        195                 200                 205             


Ala Arg Glu Leu Lys Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys 
    210                 215                 220                 


Met Gly Val Pro Ile Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg 
225                 230                 235                 240 


Val Val Asn Ala Met Gly Lys Gln Trp His Val Glu His Phe Val Cys 
                245                 250                 255     


Ala Lys Cys Glu Lys Pro Phe Leu Gly His Arg His Tyr Glu Arg Lys 
            260                 265                 270         


Gly Leu Ala Tyr Cys Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val 
        275                 280                 285             


Cys Phe His Cys Asn Arg Val Ile Glu Gly Asp Val Val Ser Ala Leu 
    290                 295                 300                 


Asn Lys Ala Trp Cys Val Asn Cys Phe Ala Cys Ser Thr Cys Asn Thr 
305                 310                 315                 320 


Lys Leu Thr Leu Lys Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val 
                325                 330                 335     


Cys Lys Lys Cys Tyr Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu 
            340                 345                 350         


Lys Lys Leu Ala Glu Thr Leu Gly Arg Lys 
        355                 360         


<210>  8195
<211>  924
<212>  DNA
<213>  Homosapiens

<400>  8195
gcaagggacg ctgctttccc ctggcagcca cactgctgag cataaatgct ttaaagtgtc     60

agcaattgat gtgtggagag aagtatgact gcattacagc ttaaagagct ttcacattca    120

ggtctctaca ggagaagacg agatcgcccc gatagtttga gagtaaatgg gttaccagag    180

gaagagctaa gcaacatggc caacgccctg gccagcgcca cttgcgagcg ctgcaagggc    240

ggctttgcgc ccgctgagaa gatcgtgaac agtaatgggg agctgtacca tgagcagtgt    300

ttcgtgtgcg ctcagtgctt ccagcagttc ccagaaggac tcttctatga ggaacgaaca    360

tgatggttaa gctaccttca ttaagcagca tgaccgcttc ctgagctcct gctgccgcat    420

ttaggccctg tcagctgtga ggccactggt gctgagtcag agggaaaagc tcagaacagc    480

cttgagcagt gaagaataaa gtgtgactca tctcgtcctg cccacccctc acactggact    540

ataaataccc tccctgggtc tgtgtgctgt tattccaaaa gatgcgatga atacccagaa    600

ctaggctatt catgggctgt tgcccagttc aagatctgtt gggtcctgag gaagattact    660

attttggcta aattgtttat cattaaaacc agcccaggga tgtgtaaacc tgcatctgga    720

gaataagaca tttctttttg gttaaatgat attagagaaa aaaactatcc aagactgcta    780

acaaataatc ttcactttca gttatatcca gcaataagtt gttttccaga aaagaaagct    840

tggaaactta cccagtttgc cttccatttg ggacatgact gatgtgcttc agtctttgta    900

taataaatgc atcttcgcca ctct                                           924


<210>  8196
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  8196

Met Thr Ala Leu Gln Leu Lys Glu Leu Ser His Ser Gly Leu Tyr Arg 
1               5                   10                  15      


Arg Arg Arg Asp Arg Pro Asp Ser Leu Arg Val Asn Gly Leu Pro Glu 
            20                  25                  30          


Glu Glu Leu Ser Asn Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu 
        35                  40                  45              


Arg Cys Lys Gly Gly Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn 
    50                  55                  60                  


Gly Glu Leu Tyr His Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln 
65                  70                  75                  80  


Gln Phe Pro Glu Gly Leu Phe Tyr Glu Glu Arg Thr 
                85                  90          


<210>  8197
<211>  4708
<212>  DNA
<213>  Homosapiens

<400>  8197
gtttatagca tagtccactg ggactgccgc tctgacaaag actgtgtcac tactttgtgg     60

aatgttattt tagaacttcc agaatgcctc agtaaatcct gactgccatg taactgtgta    120

ctgtgctgct gagctcttaa catgaagcag cagtagtgac cctggcgggc caggctgacg    180

tgcgtgggaa cagtgggagt gaccctggct gggaagcagg gaggcctgga tattgtttct    240

cctggctctg tgtcctgcca ttctcgtccc tgtgctcaga gctctcaagc acccacgatg    300

gccttctcag gccgagcgcg cccctgcatt atcccagaga acgaagaaat cccccgagca    360

gcccttaaca ctgtccacga ggccaatggg accgaggacg agagggctgt ttccaaactg    420

cagcgcaggc acagtgacgt gaaagtctac aaggagttct gtgactttta tgcgaaattc    480

aacatggcca acgccctggc cagcgccact tgcgagcgct gcaagggcgg ctttgcgccc    540

gctgagaaga tcgtgaacag taatggggag ctgtaccatg agcagtgttt cgtgtgcgct    600

cagtgcttcc agcagttccc agaaggactc ttctatgagt ttgaaggaag aaagtactgt    660

gaacatgact ttcagatgct ctttgcccct tgctgtcatc agtgtggtga attcatcatt    720

ggccgagtta tcaaagccat gaataacagc tggcatccgg agtgcttccg ctgtgacctc    780

tgccaggaag ttctggcaga tatcgggttt gtcaagaatg ctgggagaca cctgtgtcgc    840

ccctgtcata atcgtgagaa agccagaggc cttgggaaat acatctgcca gaaatgccat    900

gctatcatcg atgagcagcc tctgatattc aagaacgacc cctaccatcc agaccatttc    960

aactgcgcca actgcgggaa ggagctgact gccgatgcac gggagctgaa aggggagcta   1020

tactgcctcc catgccatga taaaatgggg gtccccatct gtggtgcttg ccgacggccc   1080

atcgaagggc gcgtggtgaa cgctatgggc aagcagtggc atgtggagca ttttgtttgt   1140

gccaagtgtg agaaaccctt tcttggacat cgccattatg agaggaaagg cctggcatat   1200

tgtgaaactc actataacca gctatttggt gatgtttgct tccactgcaa tcgtgttata   1260

gaaggtgatg tggtctctgc tcttaataag gcctggtgcg tgaactgctt tgcctgttct   1320

acctgcaaca ctaaattaac actcaagaat aagtttgtgg agtttgacat gaagccagtc   1380

tgtaagaagt gctatgagaa atttccattg gagctgaaga aaagacttaa gaaactagct   1440

gagaccttag gaaggaaata agttccttta ttttttcttt tctatgcaag ataagagatt   1500

accaacatta cttgtcttga tctacccata tttaaagcta tatctcaaag cagttgagag   1560

aagaggacct atatgaatgg ttttatgtca tttttttaat taaaaaagaa aaattcatat   1620

aatcgtgttt aaaacacaaa tgaagtcagt atttgccttt gttaaccctt atccatttgt   1680

tgacatgtag actgtttaca aaaaaaaaac acatggttaa atgttaaatt ttaattaagg   1740

cccccaaaaa ttaaatataa ctttttaaaa tgaaaggagt caccttttac atgactcagg   1800

tgaaaaaaca gtataaacat taatttactt tgtgttcaaa agaaaattcc aactgctgtt   1860

ggggaaggac acagaaaaga aaaataacca cccaagaaaa acaaaaacaa gaaaaacaaa   1920

tcttatacaa tcttagtata tttatcaaac tagtagctag aaagtgaata tgcacattac   1980

taagacaaaa aacaagtgta attcagaact acttgatttt ttttagttaa atgcaataat   2040

tattatgctt agttttataa cctgctctcc ttgtgaattc ttccttcaaa tgattactta   2100

acgcagtagt aatagctagc tgtaggatgt cctttaaatt tttgtgcaaa aaaaaattta   2160

taccaggtat ttggaaatat actttacaat attggaaaat gaagtatttt taatgtatta   2220

cagcaattat gtttctaagc ttaatgttaa gcatgtagtc ttagaatagg acatgaaatt   2280

aaattgtatg tagcttggaa tatattgctt cagaaaactg aatgtgtatg tcggtcatat   2340

tgcctttata accatgctaa tatctatgct ttatacatac tcaaacttgc cttgccttaa   2400

aaacatacat actacatact taaatcagga attctagcca tctcacagaa taccaactaa   2460

aactaagtgc attgagatct gagattggta aacccagatt catttaccac agctgtaatt   2520

aagtttttag aaactattct ctttttgggg aaatccattg aagttaattt ctgttatctt   2580

attagaagaa aatgatgttg atatgtgttt cagattttcc atttgaaatc ttataattaa   2640

tttgatttat ttactgtaag taggaggtat aaatgacact cttaaattgg aaggaggggt   2700

gttttagtgt ctgttttagg tcaaaattag tgattctatt tttatcaaaa gttttatcct   2760

gaagtttcag gaccactctt ccttaataaa cttgttaatg gaaagcgagc tttatgaaca   2820

tttaaaaatg ttgctgctgc tttgttgctt aaaaagaaag ttgccaagag agacttctta   2880

gggaaaatat ttgggttttt tttccaaaaa ttgctgaaat attgttttgc catttttaaa   2940

aagtctcagg ttattaccac tctgccatta aatatttgta tgcctgcatt tttaaaaatt   3000

ctgtgcatgt actttatgga gtacattcta tttttgtttt cagataccct acaaccaatt   3060

ttttttagta atcttttaga attgaaatta tcataaatga tcgagaataa tcatcacata   3120

gtttaagatt gtatatgttg agtagtttaa aacaatcttt gcattttaca gtaagaatca   3180

aagtcccttc agtgtgcctt tgtcagctaa tatgtgacca gcaatgacaa ccttgggagt   3240

atttattaaa tattatgcta tgaatatagg caacacagaa cagggtttgc agtatagcgt   3300

cttgatgcta aattctcata tacctctaca cgagaaatat ggaggagaaa aacaagcatt   3360

tacatatatt cttcgtcact ttgaagatgc atggcctgaa ctcgactgct tgtgtttgtt   3420

tacatatcag gcatacccag gcatctcctg cagccagagg ttccattgct gtctttgctc   3480

agtcctcttt taaaatatga attagtggac aggcacggtg cctcacacct gtaatcccag   3540

cactttggga ggtcgaggca ggtggatcac gaggtcagga gatcaagacc atcctggcta   3600

ccactgaaac cccatctcta ctacaaaaaa attagccggg cgtggtggcg ggcacctgca   3660

gtcccagcta ctcgggaggc tgaggcagga gaatggtggg aacccgggag gcagagcttg   3720

cagtgagcca agatcacgcc actgcactcc agcctgggca acagagcaag actctgtctc   3780

aaaaaaaata aataaataaa ttatgaatga gtattttcta gaaattcaac ttgctaagcc   3840

tgtaatactt aagggtagtt tatctagata cagtactttc ttccctgata agtagtatca   3900

ttggagccct taggtatagg agaagaggaa gaagtttaaa aagtgtaagt gggccgggcg   3960

tggtggctca tgcctgtaat cccagcactt tgggaggccg aggggggcgg atcacgaggt   4020

caggagatcc agactatcct ggctaacaag gtgaaacccc gtctctacta aaaatacaaa   4080

aaaaaacatt agccaggcgt ggtggcgggc gcttgtagtc ccagctactc gggaggctga   4140

ggtaggagaa tggcttgaac ccaggaggcg gagcttgcag tgagccgaga ttgcaccact   4200

gcactccagc ctgggcgaca gagcaagact ccgtctcaaa aaaaaaaaaa aagtgtaagt   4260

ggattaaaag agaaacttgg tctagttcat aatattttta atagggcttt ccctggctgc   4320

tggaaaactt aggccagtaa gcatctcttt gtttaaagtc ctacaagaca atttgaaata   4380

attcattgtt catgccaaaa ttctaagtac tgtttttctt agcaagtgta acataatcag   4440

gaacaatggg tacaagtaaa acattctttg gatgatattc aaagccttat tagcactgca   4500

cctgaataat aggtcatttt gcctcactca tttgccaaag tagccatttc taagttaagg   4560

aagtttttag ataggctcat agccttgtat ttcgttttag attgtaagct caatggcagg   4620

gatactatat tggtaattat gttttcatat agcaaccacc acagtatatt cttggtgctt   4680

aataaatgtt tataattgtt aacaataa                                      4708


<210>  8198
<211>  387
<212>  PRT
<213>  Homosapiens

<400>  8198

Met Ala Phe Ser Gly Arg Ala Arg Pro Cys Ile Ile Pro Glu Asn Glu 
1               5                   10                  15      


Glu Ile Pro Arg Ala Ala Leu Asn Thr Val His Glu Ala Asn Gly Thr 
            20                  25                  30          


Glu Asp Glu Arg Ala Val Ser Lys Leu Gln Arg Arg His Ser Asp Val 
        35                  40                  45              


Lys Val Tyr Lys Glu Phe Cys Asp Phe Tyr Ala Lys Phe Asn Met Ala 
    50                  55                  60                  


Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly Phe Ala 
65                  70                  75                  80  


Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His Glu Gln 
                85                  90                  95      


Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly Leu Phe 
            100                 105                 110         


Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln Met Leu 
        115                 120                 125             


Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly Arg Val 
    130                 135                 140                 


Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg Cys Asp 
145                 150                 155                 160 


Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn Ala Gly 
                165                 170                 175     


Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg Gly Leu 
            180                 185                 190         


Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu Gln Pro 
        195                 200                 205             


Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn Cys Ala 
    210                 215                 220                 


Asn Cys Gly Lys Glu Leu Thr Ala Asp Ala Arg Glu Leu Lys Gly Glu 
225                 230                 235                 240 


Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile Cys Gly 
                245                 250                 255     


Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Met Gly Lys 
            260                 265                 270         


Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe 
        275                 280                 285             


Leu Gly His Arg His Tyr Glu Arg Lys Gly Leu Ala Tyr Cys Glu Thr 
    290                 295                 300                 


His Tyr Asn Gln Leu Phe Gly Asp Val Cys Phe His Cys Asn Arg Val 
305                 310                 315                 320 


Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Asn 
                325                 330                 335     


Cys Phe Ala Cys Ser Thr Cys Asn Thr Lys Leu Thr Leu Lys Asn Lys 
            340                 345                 350         


Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Lys Cys Tyr Glu Lys 
        355                 360                 365             


Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ala Glu Thr Leu 
    370                 375                 380                 


Gly Arg Lys 
385         


<210>  8199
<211>  777
<212>  DNA
<213>  Homosapiens

<400>  8199
aaagggaaag ttgtcttcca gaggtgtgga ggggagtgaa gcaacaacat ggccaacgcc     60

ctggccagcg ccacttgcga gcgctgcaag ggcggctttg cgcccgctga gaagatcgtg    120

aacagtaatg gggagctgta ccatgagcag tgtttcgtgt gcgctcagtg cttccagcag    180

ttcccagaag gactcttcta tgaggaacga acatgatggt taagctacct tcattaagca    240

gcatgaccgc ttcctgagct cctgctgccg catttaggcc ctgtcagctg tgaggccact    300

ggtgctgagt cagagggaaa agctcagaac agccttgagc agtgaagaat aaagtgtgac    360

tcatctcgtc ctgcccaccc ctcacactgg actataaata ccctccctgg gtctgtgtgc    420

tgttattcca aaagatgcga tgaataccca gaactaggct attcatgggc tgttgcccag    480

ttcaagatct gttgggtcct gaggaagatt actattttgg ctaaattgtt tatcattaaa    540

accagcccag ggatgtgtaa acctgcatct ggagaataag acatttcttt ttggttaaat    600

gatattagag aaaaaaacta tccaagactg ctaacaaata atcttcactt tcagttatat    660

ccagcaataa gttgttttcc agaaaagaaa gcttggaaac ttacccagtt tgccttccat    720

ttgggacatg actgatgtgc ttcagtcttt gtataataaa tgcatcttcg ccactct       777


<210>  8200
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  8200

Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
1               5                   10                  15      


Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Glu Arg Thr 
    50                  55  


<210>  8201
<211>  651
<212>  DNA
<213>  Homosapiens

<400>  8201
ctgaagtgcc acatgcatgc caggtatttg atagctgtga ggtcagaggt ggcatctcta     60

tggcccatat gggcagtggc atgattggga caccctcaca gaccctgcat ttgtattgct    120

cagttcatcg tcctatttca gaacccagag tcccttatga cagagccttt cagacctaag    180

cagctcagct ccacatagaa aattctttct gagtcttcag ccacactcag gccccccaca    240

cacctcaccc actcctgtct ctgtgtcttt cccccttctc agaggaccac tggacctgct    300

ctaaaggaga gcgtgtggtg tacgtcaccc cctccacaac ttcccagcct cgagccagga    360

gcgtccatgc atttattttc taagggaaaa aaaaataagt attttaggga actatactgt    420

ctacatttag ctctcctggg tgtctatgtt cttttctaaa tatttgtttt tcttgatcct    480

cgggtgttag catatggtct gcacttcctt tgtagtgtat ttggtatttt caacattacc    540

gaaacccctt tcttgttgtt ttttattgtt ttgttttgtt tgagacaaag tctcattgta    600

tagcccaggt gcactccagc ctgaaaaaac agggcaagac cgtttctgaa a             651


<210>  8202
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  8202

Met Ala His Met Gly Ser Gly Met Ile Gly Thr Pro Ser Gln Thr Leu 
1               5                   10                  15      


His Leu Tyr Cys Ser Val His Arg Pro Ile Ser Glu Pro Arg Val Pro 
            20                  25                  30          


Tyr Asp Arg Ala Phe Gln Thr 
        35                  


<210>  8203
<211>  477
<212>  DNA
<213>  Homosapiens

<400>  8203
aggtgatgtc tgcagggagc catgaatcat gctgaaaaca ggattgttca aaactttgcc     60

aggaagtctc tggcagaagt gtgttagcga gtcttagcaa acacagctgc ttcctttctg    120

ttccaatcaa tcagcccagc ctaattacca cagtacaagg gtgaggaggg aaggaaattg    180

taattcacag tgatgttatc agccagcacc atgcctggga gatcaccagg gcaggagagg    240

tataaaatgc tccaggggca aggttctgag aagatgccct gccactgtat gaggccacaa    300

cctgctgtgt ataacctcat ctaagcacag agaagcacca gactgagctt gggaaatgat    360

aaagcaaact gtggacttga atgaaagaca tacaggtatt ctttgtatat tttatagtta    420

gcttctgagt ctgaaattat ttcccaaata aaaagttaaa aacaaatctc tactgaa       477


<210>  8204
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  8204

Met Leu Ser Ala Ser Thr Met Pro Gly Arg Ser Pro Gly Gln Glu Arg 
1               5                   10                  15      


Tyr Lys Met Leu Gln Gly Gln Gly Ser Glu Lys Met Pro Cys His Cys 
            20                  25                  30          


Met Arg Pro Gln Pro Ala Val Tyr Asn Leu Ile 
        35                  40              


<210>  8205
<211>  2064
<212>  DNA
<213>  Homosapiens

<400>  8205
ttagaagaaa atgatgttga tatgtgtttc agattttcca tttgaaatct tataattaat     60

ttgatttatt tactgtaagt aggaggtata aatgacactc ttaaattgga aggaggggtg    120

ttttagtgtc tgttttaggt caaaattagt gattctattt ttatcaaaag ttttatcctg    180

aagtttcagg accactcttc cttaataaac ttgttaatgg aaagcgagct ttatgaacat    240

ttaaaaatgt tgctgctgct ttgttgctta aaaagaaagt tgccaagaga gacttcttag    300

ggaaaatatt tgggtttttt ttccaaaaat tgctgaaata ttgttttgcc atttttaaaa    360

agtctcaggt tattaccact ctgccattaa atatttgtat gcctgcattt ttaaaaattc    420

tgtgcatgta ctttatggag tacattctat ttttgttttc agatacccta caaccaattt    480

tttttagtaa tcttttagaa ttgaaattat cataaatgat cgagaataat catcacatag    540

tttaagattg tatatgttga gtagtttaaa acaatctttg cattttacag taagaatcaa    600

agtcccttca gtgtgccttt gtcagctaat atgtgaccag caatgacaac cttgggagta    660

tttattaaat attatgctat gaatataggc aacacagaac agggtttgca gtatagcgtc    720

ttgatgctaa attctcatat acctctacac gagaaatatg gaggagaaaa acaagcattt    780

acatatattc ttcgtcactt tgaagatgca tggcctgaac tcgactgctt gtgtttgttt    840

acatatcagg catacccagg catctcctgc agccagaggt tccattgctg tctttgctca    900

gtcctctttt aaaatatgaa ttagtggaca ggcacggtgc ctcacacctg taatcccagc    960

actttgggag gtcgaggcag gtggatcacg aggtcaggag atcaagacca tcctggctac   1020

cactgaaacc ccatctctac tacaaaaaaa ttagccgggc gtggtggcgg gcacctgcag   1080

tcccagctac tcgggaggct gaggcaggag aatggtggga acccgggagg cagagcttgc   1140

agtgagccaa gatcacgcca ctgcactcca gcctgggcaa cagagcaaga ctctcctgta   1200

atacttaagg gtagtttatc tagatacagt actttcttcc ctgataagta gtatcattgg   1260

agcccttagg tataggagaa gaggaagaag tttaaaaagt gtaagtgggc cgggcgtggt   1320

ggctcatgcc tgtaatccca gcactttggg aggccgaggg gggcggatca cgaggtcagg   1380

agatccagac tatcctggct aacaaggtga aaccccgtct ctactaaaaa tacaaaaaaa   1440

aacattagcc aggcgtggtg gcgggcgctt gtagtcccag ctactcggga ggctgaggta   1500

ggagaatggc ttgaacccag gaggcggagc ttgcagtgag ccgagattgc accactgcac   1560

tccagcctgg gcgacagagc aagactccgt ctcaaaaaaa aaaaaaaagt gtaagtggat   1620

taaaagagaa acttggtcta gttcataata tttttaatag ggctttccct ggctgctgga   1680

aaacttaggc cagtaagcat ctctttgttt aaagtcctac aagacaattt gaaataattc   1740

attgttcatg ccaaaattct aagtactgtt tttcttagca agtgtaacat aatcaggaac   1800

aatgggtaca agtaaaacat tctttggatg atattcaaag ccttattagc actgcacctg   1860

aataataggt cattttgcct cactcatttg ccaaagtagc catttctaag ttaaggaagt   1920

ttttagatag gctcatagcc ttgtatttcg ttttagattg taagctcaat ggcagggata   1980

ctatattggt aattatgttt tcatatagca accaccacag tatattcttg gtgcttaata   2040

aatgtttata attgttaaca ataa                                          2064


<210>  8206
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  8206

Met Thr Thr Leu Gly Val Phe Ile Lys Tyr Tyr Ala Met Asn Ile Gly 
1               5                   10                  15      


Asn Thr Glu Gln Gly Leu Gln Tyr Ser Val Leu Met Leu Asn Ser His 
            20                  25                  30          


Ile Pro Leu His Glu Lys Tyr Gly Gly Glu Lys Gln Ala Phe Thr Tyr 
        35                  40                  45              


Ile Leu Arg His Phe Glu Asp Ala Trp Pro Glu Leu Asp Cys Leu Cys 
    50                  55                  60                  


Leu Phe Thr Tyr Gln Ala Tyr Pro Gly Ile Ser Cys Ser Gln Arg Phe 
65                  70                  75                  80  


His Cys Cys Leu Cys Ser Val Leu Phe 
                85                  


<210>  8207
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  8207
cacagtggtc ctccgccggc tacggcgctg cgtcactggt ttgcaggcgc tttcctcttg     60

gaagtggcga ctgctgcggg cctgagcgct ggtctcacgc gcctcgggag ccaggttggc    120

ggcgcgatga ggcgcagcaa ggctgacgtg gagcggtaca tcgcctcggt gcagggctcc    180

accccgtcgc ctcgacagaa gtcaatgaaa ggattctatt ttgcaaagct gtattatgaa    240

gctaaagaat atgatcttgc taaaaaatac atatgtactt acattaatgt gcaagagagg    300

gatcccaaag ctcacagatt tctgggtctt ctttatgaat tggaagaaaa cacagacaaa    360

gccgttgaat gttacaggcg ttcagtggaa ttaaacccaa cacaaaaaga tcttgtgttg    420

aagattgcag aattgctttg taaaaatgat gttactgatg gaagagcaaa atactggctt    480

gaaagagcag ccaaactttt cccaggaagt cctgcaattt ataaactaaa ggaacagctt    540

ctagattgtg aaggtgaaga tggatggaat aaactttttg acttgattca gtcagaactt    600

tatgtaagac ctgatgacgt ccatgtgaac atccggctag tggaggtgta tcgctcaact    660

aaaagattga aggatgctgt ggcccactgc catgaggcag agaggaacat agctttgcgt    720

tcaagtttag aatggaattc gtgtgttgta cagaccctta aggaatatct ggagtcttta    780

cagtgtttgg agtctgataa aagtgactgg cgagcaacca atacagactt actgctggcc    840

tatgctaatc ttatgcttct tacgctttcc actagagatg tgcaggaaag tagagaatta    900

ctgcaaagtt ttgatagtgc tcttcagtct gtgaaatctt tgggtggaaa tgatgaactg    960

tcagctactt tcttagaaat gaaaggacat ttctacatgc atgctggttc tctgcttttg   1020

aagatgggtc agcatagtag taatgttcaa tggcgagctc tttctgagct ggctgcattg   1080

tgctatctca tagcatttca ggttccaaga ccaaagatta aattaataaa aggtgaagct   1140

ggacaaaatc tgctggaaat gatggcctgt gaccgactga gccaatcagg gcacatgttg   1200

ctaaacttaa gtcgtggcaa gcaagatttt ttaaaagaga ttgttgaaac ttttgccaac   1260

aaaagcgggc agtctgcatt atatgatgct ctgttttcta gtcagtcacc taaggataca   1320

tcttttcttg gtagcgatga tattggaaac attgatgtac gagaaccaga gcttgaagat   1380

ttgactagat acgatgttgg tgctattcga gcacataatg gtagtcttca gcaccttact   1440

tggcttggct tacagtggaa ttcattgcct gctttacctg gaatccgaaa atggctaaaa   1500

cagcttttcc atcatttgcc ccatgaaacc tcaaggcttg aaacaaatgc acctgaatca   1560

atatgtattt tagatcttga agtatttctc cttggagtag tatataccag ccacttacaa   1620

ttaaaggaga aatgtaattc tcaccacagc tcctatcagc cgttatgcct gccccttcct   1680

gtgtgtaaac agctttgtac agaaagacaa aaatcttggt gggatgcggt ttgtactctg   1740

attcacagaa aagcagtacc tggaaacgta gcaaaattga gacttctagt tcagcatgaa   1800

ataaacactc taagagccca ggaaaaacat ggccttcaac ctgctctgct tgtacattgg   1860

gcagaatgcc ttcagaaaac gggcagcggt cttaattctt tttatgatca acgagaatac   1920

atagggagaa gtgttcatta ttggaagaaa gttttgccat tgttgaagat aataaaaaag   1980

aagaacagta ttcctgaacc tattgatcct ctgtttaaac attttcatag tgtagacatt   2040

caggcatcag aaattgttga atatgaagaa gacgcacaca taacttttgc tatattggat   2100

gcagtaaatg gaaatataga agatgctgtg actgcttttg aatctataaa aagtgttgtt   2160

tcttattgga atcttgcact gatttttcac aggaaggcag aagacattga aaatgatgcc   2220

ctttctcctg aagaacaaga agaatgcaaa aattatctga gaaagaccag ggactaccta   2280

ataaagatta tagatgacag tgattcaaat ctttcagtgg tcaagaaatt gcctgtgccc   2340

ctggagtctg taaaagagat gcttaattca gtcatgcagg aactcgaaga ctatagtgaa   2400

ggaggtcctc tctataaaaa tggttctttg cgaaatgcag attcagaaat aaaacattct   2460

acaccgtctc ctaccagata ttcactatca ccaagtaaaa gttacaagta ttctcccaaa   2520

acaccacctc gatgggcaga agatcagaat tctttactga aaatgatttg ccaacaagta   2580

gaggccatta agaaagaaat gcaggagttg aaactaaata gcagtaactc agcatcccct   2640

catcgttggc ccacagagaa ttatggacca gactcagtgc ctgatggata tcaggggtca   2700

cagacatttc atggggctcc actaacagtt gcaactactg gcccttcagt atattatagt   2760

cagtcaccag catataattc ccagtatctt ctcagaccag cagctaatgt tactcccaca   2820

aagggcccag tctatggcat gaataggctt ccaccccaac agcatattta tgcctatccg   2880

caacagatgc acacaccgcc agtgcaaagc tcatctgctt gtatgttctc tcaggagatg   2940

tatggtcctc ctgcattgcg ttttgagtct cctgcaacgg gaattctatc gcccaggggt   3000

gatgattact ttaattacaa tgttcaacag acaagcacaa atccaccttt gccagaacca   3060

ggatatttca caaaacctcc gattgcagct catgcttcaa gatctgcaga atctaagact   3120

atagaatttg ggaaaactaa ttttgttcag cccatgccgg gtgaaggatt aaggccatct   3180

ttgccaacac aagcacacac aacacagcca actcctttta aatttaactc aaatttcaaa   3240

tcaaatgatg gtgacttcac gttttcctca ccacaggttg tgacacagcc ccctcctgca   3300

gcttacagta acagtgaaag ccttttaggt ctcctgactt cagataaacc cttgcaagga   3360

gatggctata gtggagccaa accaattcct ggtggtcaaa ccattgggcc tcgaaataca   3420

ttcaattttg gaagcaaaaa tgtgtctgga atttcattta cagaaaacat ggggtcgagt   3480

cagcaaaaga attctggttt tcggcgaagt gatgatatgt ttactttcca tggtccaggg   3540

aaatcagtat ttggaacacc cactttagag acagcaaaca agaatcatga gacagatgga   3600

ggaagtgccc atggggatga tgatgatgac ggtcctcact ttgagcctgt agtacctctt   3660

cctgataaga ttgaagtaaa aactggtgag gaagatgaag aagaattctt ttgcaaccgc   3720

gcgaaattgt ttcgtttcga tgtagaatcc aaagaatgga aagaacgtgg gattggcaat   3780

gtaaaaatac tgaggcataa aacatctggt aaaattcgcc ttctaatgag acgagagcaa   3840

gtattgaaaa tctgtgcaaa tcattacatc agtccagata tgaaattgac accaaatgct   3900

ggatcagaca gatcttttgt atggcatgcc cttgattatg cagatgagtt gccaaaacca   3960

gaacaacttg ctattaggtt caaaactcct gaggaagcag cactttttaa atgcaagttt   4020

gaagaagccc agagcatttt aaaagcccca ggaacaaatg tagccatggc gtcaaatcag   4080

gctgtcagaa ttgtaaaaga acccacaagt catgataaca aggatatttg caaatctgat   4140

gctggaaacc tgaattttga atttcaggtt gcaaagaaag aagggtcttg gtggcattgt   4200

aacagctgct cattaaagaa tgcttcaact gctaagaaat gtgtatcatg ccaaaatcta   4260

aacccaagca ataaagagct cgttggccca ccattagctg aaactgtttt tactcctaaa   4320

accagcccag agaatgttca agatcgattt gcattggtga ctccaaagaa agaaggtcac   4380

tgggattgta gtatttgttt agtaagaaat gaacctactg tatctaggtg cattgcgtgt   4440

cagaatacaa aatctgctaa caaaagtgga tcttcatttg ttcatcaagc ttcatttaaa   4500

tttggccagg gagatcttcc taaacctatt aacagtgatt tcagatctgt tttttctaca   4560

aaggaaggac agtgggattg cagtgcatgt ttggtacaaa atgaggggag ctctacaaaa   4620

tgtgctgctt gtcagaatcc gagaaaacag agtctacctg ctacttctat tccaacacct   4680

gcctctttta agtttggtac ttcagagaca agtaaaactc taaaaagtgg atttgaagac   4740

atgtttgcta agaaggaagg acagtgggat tgcagttcat gcttagtgcg aaatgaagca   4800

aatgctacaa gatgtgttgc ttgtcagaat ccggataaac caagtccatc tacttctgtt   4860

ccagctcctg cctcttttaa gtttggtact tcagagacaa gcaaggctcc aaagagcgga   4920

tttgagggaa tgttcactaa gaaggaggga cagtgggatt gcagtgtgtg cttagtaaga   4980

aatgaagcca gtgctaccaa atgtattgct tgtcagaatc caggtaaaca aaatcaaact   5040

acttctgcag tttcaacacc tgcctcttca gagacaagca aggctccaaa gagcggattt   5100

gagggaatgt tcactaagaa ggagggacag tgggattgca gtgtgtgctt agtaagaaat   5160

gaagccagtg ctaccaaatg tattgcttgt cagaatccag gtaaacaaaa tcaaactact   5220

tctgcagttt caacacctgc ctcttcagag acaagcaagg ctccaaagag cggatttgag   5280

ggaatgttca ctaagaagga aggacagtgg gattgcagtg tgtgcttagt aagaaatgaa   5340

gccagtgcta ccaaatgtat tgcttgtcag tgtccaagta aacaaaatca aacaactgca   5400

atttcaacac ctgcctcttc ggagataagc aaggctccaa agagtggatt tgaaggaatg   5460

ttcatcagga aaggacagtg ggattgtagt gtttgctgtg tacaaaatga gagttcttcc   5520

ttaaaatgtg tggcttgtga tgcctctaaa ccaactcata aacctattgc agaagctcct   5580

tcagctttca cactgggctc agaaatgaag ttgcatgact cttctggaag tcaggtggga   5640

acaggattta aaagtaattt ctcagaaaaa gcttctaagt ttggcaatac agagcaagga   5700

ttcaaatttg ggcatgtgga tcaagaaaat tcaccttcat ttatgtttca gggttcttct   5760

aatacagaat ttaagtcaac caaagaagga ttttccatcc ctgtgtctgc tgatggattt   5820

aaatttggca tttcggaacc aggaaatcaa gaaaagaaaa gtgaaaagcc tcttgaaaat   5880

ggtactggct tccaggctca ggatattagt ggccagaaga atggccgtgg tgtgattttt   5940

ggccaaacaa gtagcacttt tacatttgca gatcttgcaa aatcaacttc aggagaagga   6000

tttcagtttg gcaaaaaaga ccccaatttc aagggatttt caggtgctgg agaaaaatta   6060

ttctcatcac aatacggtaa aatggccaat aaagcaaaca cttccggtga ctttgagaaa   6120

gatgatgatg cctataagac tgaggacagc gatgacatcc attttgaacc agtagttcaa   6180

atgcccgaaa aagtagaact tgtaacagga gaagaagatg aaaaagttct gtattcacag   6240

cgggtaaaac tatttagatt tgatgctgag gtaagtcagt ggaaagaaag gggcttgggg   6300

aacttaaaaa ttctcaaaaa cgaggtcaat ggcaaactaa gaatgctgat gcgaagagaa   6360

caagtactaa aagtgtgtgc taatcattgg ataacgacta cgatgaacct gaagcctctc   6420

tctggatcag atagagcatg gatgtggtta gccagtgatt tctctgatgg tgatgccaaa   6480

ctagagcagt tggcagcaaa atttaaaaca ccagagctgg ctgaagaatt caagcagaaa   6540

tttgaggaat gccagcggct tctgttagac ataccacttc aaactcccca taaacttgta   6600

gatactggca gagctgccaa gttaatacag agagctgaag aaatgaagag tggactgaaa   6660

gatttcaaaa catttttgac aaatgatcaa acaaaagtca ctgaggaaga aaataagggt   6720

tcaggtacag gtgcggccgg tgcctcagac acaacaataa aacccaatcc tgaaaacact   6780

gggcccacat tagaatggga taactatgat ttaagggaag atgctttgga tgatagtgtc   6840

agtagtagct cagtacatgc ttctccattg gcaagtagcc ctgtgagaaa aaatcttttc   6900

cgttttggtg agtcaacaac aggatttaac ttcagtttta aatctgcttt gagtccatct   6960

aagtctcctg ccaagttgaa tcagagtggg acttcagttg gcactgatga agaatctgat   7020

gttactcaag aagaagagag agatggacag tactttgaac ctgttgttcc tttacctgat   7080

ctagttgaag tatccagtgg tgaggaaaat gaacaagttg tttttagtca cagggcaaaa   7140

ctctacagat atgataaaga tgttggtcaa tggaaagaaa ggggcattgg tgatataaag   7200

attttacaga attatgataa taagcaagtt cgtatagtga tgagaaggga ccaagtatta   7260

aaactttgtg ccaatcacag aataactcca gacatgactt tgcaaaatat gaaagggaca   7320

gaaagagtat ggttgtggac tgcatgtgat tttgcagatg gagaaagaaa agtagagcat   7380

ttagctgttc gttttaaact acaggatgtt gcagactcgt ttaagaaaat ttttgatgaa   7440

gcaaaaacag cccaggaaaa agattctttg ataacacctc atgtttctcg gtcaagcact   7500

cccagagagt caccatgtgg caaaattgct gtagctgtat tagaagaaac cacaagagag   7560

aggacagatg ttattcaggg tgatgatgta gcagatgcaa cttcagaagt tgaagtgtct   7620

agcacatctg aaacaacacc aaaagcagtg gtttctcctc caaagtttgt atttggttca   7680

gagtctgtta aaagcatttt tagtagtgaa aaatcaaaac catttgcatt cggcaacagt   7740

tcagccactg ggtctttgtt tggatttagt tttaatgcac ctttgaaaag taacaatagt   7800

gaaactagtt cagtagccca gagtggatct gaaagcaaag tggaacctaa aaaatgtgaa   7860

ctgtcaaaga actctgatat cgaacagtct tcagatagca aagtcaaaaa tctctttgct   7920

tcctttccaa cggaagaatc ttcaatcaac tacacattta aaacaccaga aaaggcaaaa   7980

gagaagaaaa aacctgaaga ttctccctca gatgatgatg ttctcattgt atatgaacta   8040

actccaaccg ctgagcagaa agcccttgca accaaactta aacttcctcc aactttcttc   8100

tgctacaaga atagaccaga ttatgttagt gaagaagagg aggatgatga agatttcgaa   8160

acagctgtca agaaacttaa tggaaaacta ta                                 8192


<210>  8208
<211>  3224
<212>  PRT
<213>  Homosapiens

<400>  8208

Met Arg Arg Ser Lys Ala Asp Val Glu Arg Tyr Ile Ala Ser Val Gln 
1               5                   10                  15      


Gly Ser Thr Pro Ser Pro Arg Gln Lys Ser Met Lys Gly Phe Tyr Phe 
            20                  25                  30          


Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 
        35                  40                  45              


Ile Cys Thr Tyr Ile Asn Val Gln Glu Arg Asp Pro Lys Ala His Arg 
    50                  55                  60                  


Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Asp Lys Ala Val 
65                  70                  75                  80  


Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 
                85                  90                  95      


Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 
            100                 105                 110         


Arg Ala Lys Tyr Trp Leu Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 
        115                 120                 125             


Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 
    130                 135                 140                 


Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 
145                 150                 155                 160 


Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Val Tyr Arg 
                165                 170                 175     


Ser Thr Lys Arg Leu Lys Asp Ala Val Ala His Cys His Glu Ala Glu 
            180                 185                 190         


Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 
        195                 200                 205             


Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 
    210                 215                 220                 


Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 
225                 230                 235                 240 


Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg 
                245                 250                 255     


Glu Leu Leu Gln Ser Phe Asp Ser Ala Leu Gln Ser Val Lys Ser Leu 
            260                 265                 270         


Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly His 
        275                 280                 285             


Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His Ser 
    290                 295                 300                 


Ser Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys Tyr 
305                 310                 315                 320 


Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys Gly 
                325                 330                 335     


Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu Ser 
            340                 345                 350         


Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp Phe 
        355                 360                 365             


Leu Lys Glu Ile Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser Ala 
    370                 375                 380                 


Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser Phe 
385                 390                 395                 400 


Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Arg Glu Pro Glu Leu 
                405                 410                 415     


Glu Asp Leu Thr Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn Gly 
            420                 425                 430         


Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu Pro 
        435                 440                 445             


Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His Leu 
    450                 455                 460                 


Pro His Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile Cys 
465                 470                 475                 480 


Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser His 
                485                 490                 495     


Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln Pro 
            500                 505                 510         


Leu Cys Leu Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg Gln 
        515                 520                 525             


Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala Val 
    530                 535                 540                 


Pro Gly Asn Val Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile Asn 
545                 550                 555                 560 


Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu Val 
                565                 570                 575     


His Trp Ala Glu Cys Leu Gln Lys Thr Gly Ser Gly Leu Asn Ser Phe 
            580                 585                 590         


Tyr Asp Gln Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys Lys 
        595                 600                 605             


Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro Glu 
    610                 615                 620                 


Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln Ala 
625                 630                 635                 640 


Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Ile Thr Phe Ala Ile 
                645                 650                 655     


Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Val Thr Ala Phe Glu 
            660                 665                 670         


Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe His 
        675                 680                 685             


Arg Lys Ala Glu Asp Ile Glu Asn Asp Ala Leu Ser Pro Glu Glu Gln 
    690                 695                 700                 


Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr Arg Asp Tyr Leu Ile Lys 
705                 710                 715                 720 


Ile Ile Asp Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu Pro 
                725                 730                 735     


Val Pro Leu Glu Ser Val Lys Glu Met Leu Asn Ser Val Met Gln Glu 
            740                 745                 750         


Leu Glu Asp Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser Leu 
        755                 760                 765             


Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr Arg 
    770                 775                 780                 


Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Lys Thr Pro 
785                 790                 795                 800 


Pro Arg Trp Ala Glu Asp Gln Asn Ser Leu Leu Lys Met Ile Cys Gln 
                805                 810                 815     


Gln Val Glu Ala Ile Lys Lys Glu Met Gln Glu Leu Lys Leu Asn Ser 
            820                 825                 830         


Ser Asn Ser Ala Ser Pro His Arg Trp Pro Thr Glu Asn Tyr Gly Pro 
        835                 840                 845             


Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly Ala 
    850                 855                 860                 


Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln Ser 
865                 870                 875                 880 


Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val Thr 
                885                 890                 895     


Pro Thr Lys Gly Pro Val Tyr Gly Met Asn Arg Leu Pro Pro Gln Gln 
            900                 905                 910         


His Ile Tyr Ala Tyr Pro Gln Gln Met His Thr Pro Pro Val Gln Ser 
        915                 920                 925             


Ser Ser Ala Cys Met Phe Ser Gln Glu Met Tyr Gly Pro Pro Ala Leu 
    930                 935                 940                 


Arg Phe Glu Ser Pro Ala Thr Gly Ile Leu Ser Pro Arg Gly Asp Asp 
945                 950                 955                 960 


Tyr Phe Asn Tyr Asn Val Gln Gln Thr Ser Thr Asn Pro Pro Leu Pro 
                965                 970                 975     


Glu Pro Gly Tyr Phe Thr Lys Pro Pro Ile Ala Ala His Ala Ser Arg 
            980                 985                 990         


Ser Ala Glu Ser Lys Thr Ile Glu  Phe Gly Lys Thr Asn  Phe Val Gln 
        995                 1000                 1005             


Pro Met  Pro Gly Glu Gly Leu  Arg Pro Ser Leu Pro  Thr Gln Ala 
    1010                 1015                 1020             


His Thr  Thr Gln Pro Thr Pro  Phe Lys Phe Asn Ser  Asn Phe Lys 
    1025                 1030                 1035             


Ser Asn  Asp Gly Asp Phe Thr  Phe Ser Ser Pro Gln  Val Val Thr 
    1040                 1045                 1050             


Gln Pro  Pro Pro Ala Ala Tyr  Ser Asn Ser Glu Ser  Leu Leu Gly 
    1055                 1060                 1065             


Leu Leu  Thr Ser Asp Lys Pro  Leu Gln Gly Asp Gly  Tyr Ser Gly 
    1070                 1075                 1080             


Ala Lys  Pro Ile Pro Gly Gly  Gln Thr Ile Gly Pro  Arg Asn Thr 
    1085                 1090                 1095             


Phe Asn  Phe Gly Ser Lys Asn  Val Ser Gly Ile Ser  Phe Thr Glu 
    1100                 1105                 1110             


Asn Met  Gly Ser Ser Gln Gln  Lys Asn Ser Gly Phe  Arg Arg Ser 
    1115                 1120                 1125             


Asp Asp  Met Phe Thr Phe His  Gly Pro Gly Lys Ser  Val Phe Gly 
    1130                 1135                 1140             


Thr Pro  Thr Leu Glu Thr Ala  Asn Lys Asn His Glu  Thr Asp Gly 
    1145                 1150                 1155             


Gly Ser  Ala His Gly Asp Asp  Asp Asp Asp Gly Pro  His Phe Glu 
    1160                 1165                 1170             


Pro Val  Val Pro Leu Pro Asp  Lys Ile Glu Val Lys  Thr Gly Glu 
    1175                 1180                 1185             


Glu Asp  Glu Glu Glu Phe Phe  Cys Asn Arg Ala Lys  Leu Phe Arg 
    1190                 1195                 1200             


Phe Asp  Val Glu Ser Lys Glu  Trp Lys Glu Arg Gly  Ile Gly Asn 
    1205                 1210                 1215             


Val Lys  Ile Leu Arg His Lys  Thr Ser Gly Lys Ile  Arg Leu Leu 
    1220                 1225                 1230             


Met Arg  Arg Glu Gln Val Leu  Lys Ile Cys Ala Asn  His Tyr Ile 
    1235                 1240                 1245             


Ser Pro  Asp Met Lys Leu Thr  Pro Asn Ala Gly Ser  Asp Arg Ser 
    1250                 1255                 1260             


Phe Val  Trp His Ala Leu Asp  Tyr Ala Asp Glu Leu  Pro Lys Pro 
    1265                 1270                 1275             


Glu Gln  Leu Ala Ile Arg Phe  Lys Thr Pro Glu Glu  Ala Ala Leu 
    1280                 1285                 1290             


Phe Lys  Cys Lys Phe Glu Glu  Ala Gln Ser Ile Leu  Lys Ala Pro 
    1295                 1300                 1305             


Gly Thr  Asn Val Ala Met Ala  Ser Asn Gln Ala Val  Arg Ile Val 
    1310                 1315                 1320             


Lys Glu  Pro Thr Ser His Asp  Asn Lys Asp Ile Cys  Lys Ser Asp 
    1325                 1330                 1335             


Ala Gly  Asn Leu Asn Phe Glu  Phe Gln Val Ala Lys  Lys Glu Gly 
    1340                 1345                 1350             


Ser Trp  Trp His Cys Asn Ser  Cys Ser Leu Lys Asn  Ala Ser Thr 
    1355                 1360                 1365             


Ala Lys  Lys Cys Val Ser Cys  Gln Asn Leu Asn Pro  Ser Asn Lys 
    1370                 1375                 1380             


Glu Leu  Val Gly Pro Pro Leu  Ala Glu Thr Val Phe  Thr Pro Lys 
    1385                 1390                 1395             


Thr Ser  Pro Glu Asn Val Gln  Asp Arg Phe Ala Leu  Val Thr Pro 
    1400                 1405                 1410             


Lys Lys  Glu Gly His Trp Asp  Cys Ser Ile Cys Leu  Val Arg Asn 
    1415                 1420                 1425             


Glu Pro  Thr Val Ser Arg Cys  Ile Ala Cys Gln Asn  Thr Lys Ser 
    1430                 1435                 1440             


Ala Asn  Lys Ser Gly Ser Ser  Phe Val His Gln Ala  Ser Phe Lys 
    1445                 1450                 1455             


Phe Gly  Gln Gly Asp Leu Pro  Lys Pro Ile Asn Ser  Asp Phe Arg 
    1460                 1465                 1470             


Ser Val  Phe Ser Thr Lys Glu  Gly Gln Trp Asp Cys  Ser Ala Cys 
    1475                 1480                 1485             


Leu Val  Gln Asn Glu Gly Ser  Ser Thr Lys Cys Ala  Ala Cys Gln 
    1490                 1495                 1500             


Asn Pro  Arg Lys Gln Ser Leu  Pro Ala Thr Ser Ile  Pro Thr Pro 
    1505                 1510                 1515             


Ala Ser  Phe Lys Phe Gly Thr  Ser Glu Thr Ser Lys  Thr Leu Lys 
    1520                 1525                 1530             


Ser Gly  Phe Glu Asp Met Phe  Ala Lys Lys Glu Gly  Gln Trp Asp 
    1535                 1540                 1545             


Cys Ser  Ser Cys Leu Val Arg  Asn Glu Ala Asn Ala  Thr Arg Cys 
    1550                 1555                 1560             


Val Ala  Cys Gln Asn Pro Asp  Lys Pro Ser Pro Ser  Thr Ser Val 
    1565                 1570                 1575             


Pro Ala  Pro Ala Ser Phe Lys  Phe Gly Thr Ser Glu  Thr Ser Lys 
    1580                 1585                 1590             


Ala Pro  Lys Ser Gly Phe Glu  Gly Met Phe Thr Lys  Lys Glu Gly 
    1595                 1600                 1605             


Gln Trp  Asp Cys Ser Val Cys  Leu Val Arg Asn Glu  Ala Ser Ala 
    1610                 1615                 1620             


Thr Lys  Cys Ile Ala Cys Gln  Asn Pro Gly Lys Gln  Asn Gln Thr 
    1625                 1630                 1635             


Thr Ser  Ala Val Ser Thr Pro  Ala Ser Ser Glu Thr  Ser Lys Ala 
    1640                 1645                 1650             


Pro Lys  Ser Gly Phe Glu Gly  Met Phe Thr Lys Lys  Glu Gly Gln 
    1655                 1660                 1665             


Trp Asp  Cys Ser Val Cys Leu  Val Arg Asn Glu Ala  Ser Ala Thr 
    1670                 1675                 1680             


Lys Cys  Ile Ala Cys Gln Asn  Pro Gly Lys Gln Asn  Gln Thr Thr 
    1685                 1690                 1695             


Ser Ala  Val Ser Thr Pro Ala  Ser Ser Glu Thr Ser  Lys Ala Pro 
    1700                 1705                 1710             


Lys Ser  Gly Phe Glu Gly Met  Phe Thr Lys Lys Glu  Gly Gln Trp 
    1715                 1720                 1725             


Asp Cys  Ser Val Cys Leu Val  Arg Asn Glu Ala Ser  Ala Thr Lys 
    1730                 1735                 1740             


Cys Ile  Ala Cys Gln Cys Pro  Ser Lys Gln Asn Gln  Thr Thr Ala 
    1745                 1750                 1755             


Ile Ser  Thr Pro Ala Ser Ser  Glu Ile Ser Lys Ala  Pro Lys Ser 
    1760                 1765                 1770             


Gly Phe  Glu Gly Met Phe Ile  Arg Lys Gly Gln Trp  Asp Cys Ser 
    1775                 1780                 1785             


Val Cys  Cys Val Gln Asn Glu  Ser Ser Ser Leu Lys  Cys Val Ala 
    1790                 1795                 1800             


Cys Asp  Ala Ser Lys Pro Thr  His Lys Pro Ile Ala  Glu Ala Pro 
    1805                 1810                 1815             


Ser Ala  Phe Thr Leu Gly Ser  Glu Met Lys Leu His  Asp Ser Ser 
    1820                 1825                 1830             


Gly Ser  Gln Val Gly Thr Gly  Phe Lys Ser Asn Phe  Ser Glu Lys 
    1835                 1840                 1845             


Ala Ser  Lys Phe Gly Asn Thr  Glu Gln Gly Phe Lys  Phe Gly His 
    1850                 1855                 1860             


Val Asp  Gln Glu Asn Ser Pro  Ser Phe Met Phe Gln  Gly Ser Ser 
    1865                 1870                 1875             


Asn Thr  Glu Phe Lys Ser Thr  Lys Glu Gly Phe Ser  Ile Pro Val 
    1880                 1885                 1890             


Ser Ala  Asp Gly Phe Lys Phe  Gly Ile Ser Glu Pro  Gly Asn Gln 
    1895                 1900                 1905             


Glu Lys  Lys Ser Glu Lys Pro  Leu Glu Asn Gly Thr  Gly Phe Gln 
    1910                 1915                 1920             


Ala Gln  Asp Ile Ser Gly Gln  Lys Asn Gly Arg Gly  Val Ile Phe 
    1925                 1930                 1935             


Gly Gln  Thr Ser Ser Thr Phe  Thr Phe Ala Asp Leu  Ala Lys Ser 
    1940                 1945                 1950             


Thr Ser  Gly Glu Gly Phe Gln  Phe Gly Lys Lys Asp  Pro Asn Phe 
    1955                 1960                 1965             


Lys Gly  Phe Ser Gly Ala Gly  Glu Lys Leu Phe Ser  Ser Gln Tyr 
    1970                 1975                 1980             


Gly Lys  Met Ala Asn Lys Ala  Asn Thr Ser Gly Asp  Phe Glu Lys 
    1985                 1990                 1995             


Asp Asp  Asp Ala Tyr Lys Thr  Glu Asp Ser Asp Asp  Ile His Phe 
    2000                 2005                 2010             


Glu Pro  Val Val Gln Met Pro  Glu Lys Val Glu Leu  Val Thr Gly 
    2015                 2020                 2025             


Glu Glu  Asp Glu Lys Val Leu  Tyr Ser Gln Arg Val  Lys Leu Phe 
    2030                 2035                 2040             


Arg Phe  Asp Ala Glu Val Ser  Gln Trp Lys Glu Arg  Gly Leu Gly 
    2045                 2050                 2055             


Asn Leu  Lys Ile Leu Lys Asn  Glu Val Asn Gly Lys  Leu Arg Met 
    2060                 2065                 2070             


Leu Met  Arg Arg Glu Gln Val  Leu Lys Val Cys Ala  Asn His Trp 
    2075                 2080                 2085             


Ile Thr  Thr Thr Met Asn Leu  Lys Pro Leu Ser Gly  Ser Asp Arg 
    2090                 2095                 2100             


Ala Trp  Met Trp Leu Ala Ser  Asp Phe Ser Asp Gly  Asp Ala Lys 
    2105                 2110                 2115             


Leu Glu  Gln Leu Ala Ala Lys  Phe Lys Thr Pro Glu  Leu Ala Glu 
    2120                 2125                 2130             


Glu Phe  Lys Gln Lys Phe Glu  Glu Cys Gln Arg Leu  Leu Leu Asp 
    2135                 2140                 2145             


Ile Pro  Leu Gln Thr Pro His  Lys Leu Val Asp Thr  Gly Arg Ala 
    2150                 2155                 2160             


Ala Lys  Leu Ile Gln Arg Ala  Glu Glu Met Lys Ser  Gly Leu Lys 
    2165                 2170                 2175             


Asp Phe  Lys Thr Phe Leu Thr  Asn Asp Gln Thr Lys  Val Thr Glu 
    2180                 2185                 2190             


Glu Glu  Asn Lys Gly Ser Gly  Thr Gly Ala Ala Gly  Ala Ser Asp 
    2195                 2200                 2205             


Thr Thr  Ile Lys Pro Asn Pro  Glu Asn Thr Gly Pro  Thr Leu Glu 
    2210                 2215                 2220             


Trp Asp  Asn Tyr Asp Leu Arg  Glu Asp Ala Leu Asp  Asp Ser Val 
    2225                 2230                 2235             


Ser Ser  Ser Ser Val His Ala  Ser Pro Leu Ala Ser  Ser Pro Val 
    2240                 2245                 2250             


Arg Lys  Asn Leu Phe Arg Phe  Gly Glu Ser Thr Thr  Gly Phe Asn 
    2255                 2260                 2265             


Phe Ser  Phe Lys Ser Ala Leu  Ser Pro Ser Lys Ser  Pro Ala Lys 
    2270                 2275                 2280             


Leu Asn  Gln Ser Gly Thr Ser  Val Gly Thr Asp Glu  Glu Ser Asp 
    2285                 2290                 2295             


Val Thr  Gln Glu Glu Glu Arg  Asp Gly Gln Tyr Phe  Glu Pro Val 
    2300                 2305                 2310             


Val Pro  Leu Pro Asp Leu Val  Glu Val Ser Ser Gly  Glu Glu Asn 
    2315                 2320                 2325             


Glu Gln  Val Val Phe Ser His  Arg Ala Lys Leu Tyr  Arg Tyr Asp 
    2330                 2335                 2340             


Lys Asp  Val Gly Gln Trp Lys  Glu Arg Gly Ile Gly  Asp Ile Lys 
    2345                 2350                 2355             


Ile Leu  Gln Asn Tyr Asp Asn  Lys Gln Val Arg Ile  Val Met Arg 
    2360                 2365                 2370             


Arg Asp  Gln Val Leu Lys Leu  Cys Ala Asn His Arg  Ile Thr Pro 
    2375                 2380                 2385             


Asp Met  Thr Leu Gln Asn Met  Lys Gly Thr Glu Arg  Val Trp Leu 
    2390                 2395                 2400             


Trp Thr  Ala Cys Asp Phe Ala  Asp Gly Glu Arg Lys  Val Glu His 
    2405                 2410                 2415             


Leu Ala  Val Arg Phe Lys Leu  Gln Asp Val Ala Asp  Ser Phe Lys 
    2420                 2425                 2430             


Lys Ile  Phe Asp Glu Ala Lys  Thr Ala Gln Glu Lys  Asp Ser Leu 
    2435                 2440                 2445             


Ile Thr  Pro His Val Ser Arg  Ser Ser Thr Pro Arg  Glu Ser Pro 
    2450                 2455                 2460             


Cys Gly  Lys Ile Ala Val Ala  Val Leu Glu Glu Thr  Thr Arg Glu 
    2465                 2470                 2475             


Arg Thr  Asp Val Ile Gln Gly  Asp Asp Val Ala Asp  Ala Thr Ser 
    2480                 2485                 2490             


Glu Val  Glu Val Ser Ser Thr  Ser Glu Thr Thr Pro  Lys Ala Val 
    2495                 2500                 2505             


Val Ser  Pro Pro Lys Phe Val  Phe Gly Ser Glu Ser  Val Lys Ser 
    2510                 2515                 2520             


Ile Phe  Ser Ser Glu Lys Ser  Lys Pro Phe Ala Phe  Gly Asn Ser 
    2525                 2530                 2535             


Ser Ala  Thr Gly Ser Leu Phe  Gly Phe Ser Phe Asn  Ala Pro Leu 
    2540                 2545                 2550             


Lys Ser  Asn Asn Ser Glu Thr  Ser Ser Val Ala Gln  Ser Gly Ser 
    2555                 2560                 2565             


Glu Ser  Lys Val Glu Pro Lys  Lys Cys Glu Leu Ser  Lys Asn Ser 
    2570                 2575                 2580             


Asp Ile  Glu Gln Ser Ser Asp  Ser Lys Val Lys Asn  Leu Phe Ala 
    2585                 2590                 2595             


Ser Phe  Pro Thr Glu Glu Ser  Ser Ile Asn Tyr Thr  Phe Lys Thr 
    2600                 2605                 2610             


Pro Glu  Lys Ala Lys Glu Lys  Lys Lys Pro Glu Asp  Ser Pro Ser 
    2615                 2620                 2625             


Asp Asp  Asp Val Leu Ile Val  Tyr Glu Leu Thr Pro  Thr Ala Glu 
    2630                 2635                 2640             


Gln Lys  Ala Leu Ala Thr Lys  Leu Lys Leu Pro Pro  Thr Phe Phe 
    2645                 2650                 2655             


Cys Tyr  Lys Asn Arg Pro Asp  Tyr Val Ser Glu Glu  Glu Glu Asp 
    2660                 2665                 2670             


Asp Glu  Asp Phe Glu Thr Ala  Val Lys Lys Leu Asn  Gly Lys Leu 
    2675                 2680                 2685             


Tyr Leu  Asp Gly Ser Glu Lys  Cys Arg Pro Leu Glu  Glu Asn Thr 
    2690                 2695                 2700             


Ala Asp  Asn Glu Lys Glu Cys  Ile Ile Val Trp Glu  Lys Lys Pro 
    2705                 2710                 2715             


Thr Val  Glu Glu Lys Ala Lys  Ala Asp Thr Leu Lys  Leu Pro Pro 
    2720                 2725                 2730             


Thr Phe  Phe Cys Gly Val Cys  Ser Asp Thr Asp Glu  Asp Asn Gly 
    2735                 2740                 2745             


Asn Gly  Glu Asp Phe Gln Ser  Glu Leu Gln Lys Val  Gln Glu Ala 
    2750                 2755                 2760             


Gln Lys  Ser Gln Thr Glu Glu  Ile Thr Ser Thr Thr  Asp Ser Val 
    2765                 2770                 2775             


Tyr Thr  Gly Gly Thr Glu Val  Met Val Pro Ser Phe  Cys Lys Ser 
    2780                 2785                 2790             


Glu Glu  Pro Asp Ser Ile Thr  Lys Ser Ile Ser Ser  Pro Ser Val 
    2795                 2800                 2805             


Ser Ser  Glu Thr Met Asp Lys  Pro Val Asp Leu Ser  Thr Arg Lys 
    2810                 2815                 2820             


Glu Ile  Asp Thr Asp Ser Thr  Ser Gln Gly Glu Ser  Lys Ile Val 
    2825                 2830                 2835             


Ser Phe  Gly Phe Gly Ser Ser  Thr Gly Leu Ser Phe  Ala Asp Leu 
    2840                 2845                 2850             


Ala Ser  Ser Asn Ser Gly Asp  Phe Ala Phe Gly Ser  Lys Asp Lys 
    2855                 2860                 2865             


Asn Phe  Gln Trp Ala Asn Thr  Gly Ala Ala Val Phe  Gly Thr Gln 
    2870                 2875                 2880             


Ser Val  Gly Thr Gln Ser Ala  Gly Lys Val Gly Glu  Asp Glu Asp 
    2885                 2890                 2895             


Gly Ser  Asp Glu Glu Val Val  His Asn Glu Asp Ile  His Phe Glu 
    2900                 2905                 2910             


Pro Ile  Val Ser Leu Pro Glu  Val Glu Val Lys Ser  Gly Glu Glu 
    2915                 2920                 2925             


Asp Glu  Glu Ile Leu Phe Lys  Glu Arg Ala Lys Leu  Tyr Arg Trp 
    2930                 2935                 2940             


Asp Arg  Asp Val Ser Gln Trp  Lys Glu Arg Gly Val  Gly Asp Ile 
    2945                 2950                 2955             


Lys Ile  Leu Trp His Thr Met  Lys Asn Tyr Tyr Arg  Ile Leu Met 
    2960                 2965                 2970             


Arg Arg  Asp Gln Val Phe Lys  Val Cys Ala Asn His  Val Ile Thr 
    2975                 2980                 2985             


Lys Thr  Met Glu Leu Lys Pro  Leu Asn Val Ser Asn  Asn Ala Leu 
    2990                 2995                 3000             


Val Trp  Thr Ala Ser Asp Tyr  Ala Asp Gly Glu Ala  Lys Val Glu 
    3005                 3010                 3015             


Gln Leu  Ala Val Arg Phe Lys  Thr Lys Glu Val Ala  Asp Cys Phe 
    3020                 3025                 3030             


Lys Lys  Thr Phe Glu Glu Cys  Gln Gln Asn Leu Met  Lys Leu Gln 
    3035                 3040                 3045             


Lys Gly  His Val Ser Leu Ala  Ala Glu Leu Ser Lys  Glu Thr Asn 
    3050                 3055                 3060             


Pro Val  Val Phe Phe Asp Val  Cys Ala Asp Gly Glu  Pro Leu Gly 
    3065                 3070                 3075             


Arg Ile  Thr Met Glu Leu Phe  Ser Asn Ile Val Pro  Arg Thr Ala 
    3080                 3085                 3090             


Glu Asn  Phe Arg Ala Leu Cys  Thr Gly Glu Lys Gly  Phe Gly Phe 
    3095                 3100                 3105             


Lys Asn  Ser Ile Phe His Arg  Val Ile Pro Asp Phe  Val Cys Gln 
    3110                 3115                 3120             


Gly Gly  Asp Ile Thr Lys His  Asp Gly Thr Gly Gly  Gln Ser Ile 
    3125                 3130                 3135             


Tyr Gly  Asp Lys Phe Glu Asp  Glu Asn Phe Asp Val  Lys His Thr 
    3140                 3145                 3150             


Gly Pro  Gly Leu Leu Ser Met  Ala Asn Gln Gly Gln  Asn Thr Asn 
    3155                 3160                 3165             


Asn Ser  Gln Phe Val Ile Thr  Leu Lys Lys Ala Glu  His Leu Asp 
    3170                 3175                 3180             


Phe Lys  His Val Val Phe Gly  Phe Val Lys Asp Gly  Met Asp Thr 
    3185                 3190                 3195             


Val Lys  Lys Ile Glu Ser Phe  Gly Ser Pro Lys Gly  Ser Val Cys 
    3200                 3205                 3210             


Arg Arg  Ile Thr Ile Thr Glu  Cys Gly Gln Ile 
    3215                 3220                 


<210>  8209
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  8209
cacagtggtc ctccgccggc tacggcgctg cgtcactggt ttgcaggcgc tttcctcttg     60

gaagtggcga ctgctgcggg cctgagcgct ggtctcacgc gcctcgggag ccaggttggc    120

ggcgcgatga ggcgcagcaa ggctgacgtg gagcggtaca tcgcctcggt gcagggctcc    180

accccgtcgc ctcgacagaa gtcaatgaaa ggattctatt ttgcaaagct gtattatgaa    240

gctaaagaat atgatcttgc taaaaaatac atatgtactt acattaatgt gcaagagagg    300

gatcccaaag ctcacagatt tctgggtctt ctttatgaat tggaagaaaa cacagacaaa    360

gccgttgaat gttacaggcg ttcagtggaa ttaaacccaa cacaaaaaga tcttgtgttg    420

aagattgcag aattgctttg taaaaatgat gttactgatg gaagagcaaa atactggctt    480

gaaagagcag ccaaactttt cccaggaagt cctgcaattt ataaactaaa ggaacagctt    540

ctagattgtg aaggtgaaga tggatggaat aaactttttg acttgattca gtcagaactt    600

tatgtaagac ctgatgacgt ccatgtgaac atccggctag tggaggtgta tcgctcaact    660

aaaagattga aggatgctgt ggcccactgc catgaggcag agaggaacat agctttgcgt    720

tcaagtttag aatggaattc gtgtgttgta cagaccctta aggaatatct ggagtcttta    780

cagtgtttgg agtctgataa aagtgactgg cgagcaacca atacagactt actgctggcc    840

tatgctaatc ttatgcttct tacgctttcc actagagatg tgcaggaaag tagagaatta    900

ctgcaaagtt ttgatagtgc tcttcagtct gtgaaatctt tgggtggaaa tgatgaactg    960

tcagctactt tcttagaaat gaaaggacat ttctacatgc atgctggttc tctgcttttg   1020

aagatgggtc agcatagtag taatgttcaa tggcgagctc tttctgagct ggctgcattg   1080

tgctatctca tagcatttca ggttccaaga ccaaagatta aattaataaa aggtgaagct   1140

ggacaaaatc tgctggaaat gatggcctgt gaccgactga gccaatcagg gcacatgttg   1200

ctaaacttaa gtcgtggcaa gcaagatttt ttaaaagaga ttgttgaaac ttttgccaac   1260

aaaagcgggc agtctgcatt atatgatgct ctgttttcta gtcagtcacc taaggataca   1320

tcttttcttg gtagcgatga tattggaaac attgatgtac gagaaccaga gcttgaagat   1380

ttgactagat acgatgttgg tgctattcga gcacataatg gtagtcttca gcaccttact   1440

tggcttggct tacagtggaa ttcattgcct gctttacctg gaatccgaaa atggctaaaa   1500

cagcttttcc atcatttgcc ccatgaaacc tcaaggcttg aaacaaatgc acctgaatca   1560

atatgtattt tagatcttga agtatttctc cttggagtag tatataccag ccacttacaa   1620

ttaaaggaga aatgtaattc tcaccacagc tcctatcagc cgttatgcct gccccttcct   1680

gtgtgtaaac agctttgtac agaaagacaa aaatcttggt gggatgcggt ttgtactctg   1740

attcacagaa aagcagtacc tggaaacgta gcaaaattga gacttctagt tcagcatgaa   1800

ataaacactc taagagccca ggaaaaacat ggccttcaac ctgctctgct tgtacattgg   1860

gcagaatgcc ttcagaaaac gggcagcggt cttaattctt tttatgatca acgagaatac   1920

atagggagaa gtgttcatta ttggaagaaa gttttgccat tgttgaagat aataaaaaag   1980

aagaacagta ttcctgaacc tattgatcct ctgtttaaac attttcatag tgtagacatt   2040

caggcatcag aaattgttga atatgaagaa gacgcacaca taacttttgc tatattggat   2100

gcagtaaatg gaaatataga agatgctgtg actgcttttg aatctataaa aagtgttgtt   2160

tcttattgga atcttgcact gatttttcac aggaaggcag aagacattga aaatgatgcc   2220

ctttctcctg aagaacaaga agaatgcaaa aattatctga gaaagaccag ggactaccta   2280

ataaagatta tagatgacag tgattcaaat ctttcagtgg tcaagaaatt gcctgtgccc   2340

ctggagtctg taaaagagat gcttaattca gtcatgcagg aactcgaaga ctatagtgaa   2400

ggaggtcctc tctataaaaa tggttctttg cgaaatgcag attcagaaat aaaacattct   2460

acaccgtctc ctaccagata ttcactatca ccaagtaaaa gttacaagta ttctcccaaa   2520

acaccacctc gatgggcaga agatcagaat tctttactga aaatgatttg ccaacaagta   2580

gaggccatta agaaagaaat gcaggagttg aaactaaata gcagtaactc agcatcccct   2640

catcgttggc ccacagagaa ttatggacca gactcagtgc ctgatggata tcaggggtca   2700

cagacatttc atggggctcc actaacagtt gcaactactg gcccttcagt atattatagt   2760

cagtcaccag catataattc ccagtatctt ctcagaccag cagctaatgt tactcccaca   2820

aagggcccag tctatggcat gaataggctt ccaccccaac agcatattta tgcctatccg   2880

caacagatgc acacaccgcc agtgcaaagc tcatctgctt gtatgttctc tcaggagatg   2940

tatggtcctc ctgcattgcg ttttgagtct cctgcaacgg gaattctatc gcccaggggt   3000

gatgattact ttaattacaa tgttcaacag acaagcacaa atccaccttt gccagaacca   3060

ggatatttca caaaacctcc gattgcagct catgcttcaa gatctgcaga atctaagact   3120

atagaatttg ggaaaactaa ttttgttcag cccatgccgg gtgaaggatt aaggccatct   3180

ttgccaacac aagcacacac aacacagcca actcctttta aatttaactc aaatttcaaa   3240

tcaaatgatg gtgacttcac gttttcctca ccacaggttg tgacacagcc ccctcctgca   3300

gcttacagta acagtgaaag ccttttaggt ctcctgactt cagataaacc cttgcaagga   3360

gatggctata gtggagccaa accaattcct ggtggtcaaa ccattgggcc tcgaaataca   3420

ttcaattttg gaagcaaaaa tgtgtctgga atttcattta cagaaaacat ggggtcgagt   3480

cagcaaaaga attctggttt tcggcgaagt gatgatatgt ttactttcca tggtccaggg   3540

aaatcagtat ttggaacacc cactttagag acagcaaaca agaatcatga gacagatgga   3600

ggaagtgccc atggggatga tgatgatgac ggtcctcact ttgagcctgt agtacctctt   3660

cctgataaga ttgaagtaaa aactggtgag gaagatgaag aagaattctt ttgcaaccgc   3720

gcgaaattgt ttcgtttcga tgtagaatcc aaagaatgga aagaacgtgg gattggcaat   3780

gtaaaaatac tgaggcataa aacatctggt aaaattcgcc ttctaatgag acgagagcaa   3840

gtattgaaaa tctgtgcaaa tcattacatc agtccagata tgaaattgac accaaatgct   3900

ggatcagaca gatcttttgt atggcatgcc cttgattatg cagatgagtt gccaaaacca   3960

gaacaacttg ctattaggtt caaaactcct gaggaagcag cactttttaa atgcaagttt   4020

gaagaagccc agagcatttt aaaagcccca ggaacaaatg tagccatggc gtcaaatcag   4080

gctgtcagaa ttgtaaaaga acccacaagt catgataaca aggatatttg caaatctgat   4140

gctggaaacc tgaattttga atttcaggtt gcaaagaaag aagggtcttg gtggcattgt   4200

aacagctgct cattaaagaa tgcttcaact gctaagaaat gtgtatcatg ccaaaatcta   4260

aacccaagca ataaagagct cgttggccca ccattagctg aaactgtttt tactcctaaa   4320

accagcccag agaatgttca agatcgattt gcattggtga ctccaaagaa agaaggtcac   4380

tgggattgta gtatttgttt agtaagaaat gaacctactg tatctaggtg cattgcgtgt   4440

cagaatacaa aatctgctaa caaaagtgga tcttcatttg ttcatcaagc ttcatttaaa   4500

tttggccagg gagatcttcc taaacctatt aacagtgatt tcagatctgt tttttctaca   4560

aaggaaggac agtgggattg cagtgcatgt ttggtacaaa atgaggggag ctctacaaaa   4620

tgtgctgctt gtcagaatcc gagaaaacag agtctacctg ctacttctat tccaacacct   4680

gcctctttta agtttggtac ttcagagaca agtaaaactc taaaaagtgg atttgaagac   4740

atgtttgcta agaaggaagg acagtgggat tgcagttcat gcttagtgcg aaatgaagca   4800

aatgctacaa gatgtgttgc ttgtcagaat ccggataaac caagtccatc tacttctgtt   4860

ccagctcctg cctcttttaa gtttggtact tcagagacaa gcaaggctcc aaagagcgga   4920

tttgagggaa tgttcactaa gaaggaggga cagtgggatt gcagtgtgtg cttagtaaga   4980

aatgaagcca gtgctaccaa atgtattgct tgtcagaatc caggtaaaca aaatcaaact   5040

acttctgcag tttcaacacc tgcctcttca gagacaagca aggctccaaa gagcggattt   5100

gagggaatgt tcactaagaa ggagggacag tgggattgca gtgtgtgctt agtaagaaat   5160

gaagccagtg ctaccaaatg tattgcttgt cagaatccag gtaaacaaaa tcaaactact   5220

tctgcagttt caacacctgc ctcttcagag acaagcaagg ctccaaagag cggatttgag   5280

ggaatgttca ctaagaagga aggacagtgg gattgcagtg tgtgcttagt aagaaatgaa   5340

gccagtgcta ccaaatgtat tgcttgtcag tgtccaagta aacaaaatca aacaactgca   5400

atttcaacac ctgcctcttc ggagataagc aaggctccaa agagtggatt tgaaggaatg   5460

ttcatcagga aaggacagtg ggattgtagt gtttgctgtg tacaaaatga gagttcttcc   5520

ttaaaatgtg tggcttgtga tgcctctaaa ccaactcata aacctattgc agaagctcct   5580

tcagctttca cactgggctc agaaatgaag ttgcatgact cttctggaag tcaggtggga   5640

acaggattta aaagtaattt ctcagaaaaa gcttctaagt ttggcaatac agagcaagga   5700

ttcaaatttg ggcatgtgga tcaagaaaat tcaccttcat ttatgtttca gggttcttct   5760

aatacagaat ttaagtcaac caaagaagga ttttccatcc ctgtgtctgc tgatggattt   5820

aaatttggca tttcggaacc aggaaatcaa gaaaagaaaa gtgaaaagcc tcttgaaaat   5880

ggtactggct tccaggctca ggatattagt ggccagaaga atggccgtgg tgtgattttt   5940

ggccaaacaa gtagcacttt tacatttgca gatcttgcaa aatcaacttc aggagaagga   6000

tttcagtttg gcaaaaaaga ccccaatttc aagggatttt caggtgctgg agaaaaatta   6060

ttctcatcac aatacggtaa aatggccaat aaagcaaaca cttccggtga ctttgagaaa   6120

gatgatgatg cctataagac tgaggacagc gatgacatcc attttgaacc agtagttcaa   6180

atgcccgaaa aagtagaact tgtaacagga gaagaagatg aaaaagttct gtattcacag   6240

cgggtaaaac tatttagatt tgatgctgag gtaagtcagt ggaaagaaag gggcttgggg   6300

aacttaaaaa ttctcaaaaa cgaggtcaat ggcaaactaa gaatgctgat gcgaagagaa   6360

caagtactaa aagtgtgtgc taatcattgg ataacgacta cgatgaacct gaagcctctc   6420

tctggatcag atagagcatg gatgtggtta gccagtgatt tctctgatgg tgatgccaaa   6480

ctagagcagt tggcagcaaa atttaaaaca ccagagctgg ctgaagaatt caagcagaaa   6540

tttgaggaat gccagcggct tctgttagac ataccacttc aaactcccca taaacttgta   6600

gatactggca gagctgccaa gttaatacag agagctgaag aaatgaagag tggactgaaa   6660

gatttcaaaa catttttgac aaatgatcaa acaaaagtca ctgaggaaga aaataagggt   6720

tcaggtacag gtgcggccgg tgcctcagac acaacaataa aacccaatcc tgaaaacact   6780

gggcccacat tagaatggga taactatgat ttaagggaag atgctttgga tgatagtgtc   6840

agtagtagct cagtacatgc ttctccattg gcaagtagcc ctgtgagaaa aaatcttttc   6900

cgttttggtg agtcaacaac aggatttaac ttcagtttta aatctgcttt gagtccatct   6960

aagtctcctg ccaagttgaa tcagagtggg acttcagttg gcactgatga agaatctgat   7020

gttactcaag aagaagagag agatggacag tactttgaac ctgttgttcc tttacctgat   7080

ctagttgaag tatccagtgg tgaggaaaat gaacaagttg tttttagtca cagggcaaaa   7140

ctctacagat atgataaaga tgttggtcaa tggaaagaaa ggggcattgg tgatataaag   7200

attttacaga attatgataa taagcaagtt cgtatagtga tgagaaggga ccaagtatta   7260

aaactttgtg ccaatcacag aataactcca gacatgactt tgcaaaatat gaaagggaca   7320

gaaagagtat ggttgtggac tgcatgtgat tttgcagatg gagaaagaaa agtagagcat   7380

ttagctgttc gttttaaact acaggatgtt gcagactcgt ttaagaaaat ttttgatgaa   7440

gcaaaaacag cccaggaaaa agattctttg ataacacctc atgtttctcg gtcaagcact   7500

cccagagagt caccatgtgg caaaattgct gtagctgtat tagaagaaac cacaagagag   7560

aggacagatg ttattcaggg tgatgatgta gcagatgcaa cttcagaagt tgaagtgtct   7620

agcacatctg aaacaacacc aaaagcagtg gtttctcctc caaagtttgt atttggttca   7680

gagtctgtta aaagcatttt tagtagtgaa aaatcaaaac catttgcatt cggcaacagt   7740

tcagccactg ggtctttgtt tggatttagt tttaatgcac ctttgaaaag taacaatagt   7800

gaaactagtt cagtagccca gagtggatct gaaagcaaag tggaacctaa aaaatgtgaa   7860

ctgtcaaaga actctgatat cgaacagtct tcagatagca aagtcaaaaa tctctttgct   7920

tcctttccaa cggaagaatc ttcaatcaac tacacattta aaacaccaga aaaggcaaaa   7980

gagaagaaaa aacctgaaga ttctccctca gatgatgatg ttctcattgt atatgaacta   8040

actccaaccg ctgagcagaa agcccttgca accaaactta aacttcctcc aactttcttc   8100

tgctacaaga atagaccaga ttatgttagt gaagaagagg aggatgatga agatttcgaa   8160

acagctgtca agaaacttaa tggaaaacta ta                                 8192


<210>  8210
<211>  3224
<212>  PRT
<213>  Homosapiens

<400>  8210

Met Arg Arg Ser Lys Ala Asp Val Glu Arg Tyr Ile Ala Ser Val Gln 
1               5                   10                  15      


Gly Ser Thr Pro Ser Pro Arg Gln Lys Ser Met Lys Gly Phe Tyr Phe 
            20                  25                  30          


Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 
        35                  40                  45              


Ile Cys Thr Tyr Ile Asn Val Gln Glu Arg Asp Pro Lys Ala His Arg 
    50                  55                  60                  


Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Asp Lys Ala Val 
65                  70                  75                  80  


Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 
                85                  90                  95      


Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 
            100                 105                 110         


Arg Ala Lys Tyr Trp Leu Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 
        115                 120                 125             


Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 
    130                 135                 140                 


Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 
145                 150                 155                 160 


Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Val Tyr Arg 
                165                 170                 175     


Ser Thr Lys Arg Leu Lys Asp Ala Val Ala His Cys His Glu Ala Glu 
            180                 185                 190         


Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 
        195                 200                 205             


Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 
    210                 215                 220                 


Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 
225                 230                 235                 240 


Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg 
                245                 250                 255     


Glu Leu Leu Gln Ser Phe Asp Ser Ala Leu Gln Ser Val Lys Ser Leu 
            260                 265                 270         


Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly His 
        275                 280                 285             


Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His Ser 
    290                 295                 300                 


Ser Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys Tyr 
305                 310                 315                 320 


Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys Gly 
                325                 330                 335     


Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu Ser 
            340                 345                 350         


Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp Phe 
        355                 360                 365             


Leu Lys Glu Ile Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser Ala 
    370                 375                 380                 


Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser Phe 
385                 390                 395                 400 


Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Arg Glu Pro Glu Leu 
                405                 410                 415     


Glu Asp Leu Thr Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn Gly 
            420                 425                 430         


Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu Pro 
        435                 440                 445             


Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His Leu 
    450                 455                 460                 


Pro His Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile Cys 
465                 470                 475                 480 


Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser His 
                485                 490                 495     


Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln Pro 
            500                 505                 510         


Leu Cys Leu Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg Gln 
        515                 520                 525             


Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala Val 
    530                 535                 540                 


Pro Gly Asn Val Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile Asn 
545                 550                 555                 560 


Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu Val 
                565                 570                 575     


His Trp Ala Glu Cys Leu Gln Lys Thr Gly Ser Gly Leu Asn Ser Phe 
            580                 585                 590         


Tyr Asp Gln Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys Lys 
        595                 600                 605             


Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro Glu 
    610                 615                 620                 


Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln Ala 
625                 630                 635                 640 


Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Ile Thr Phe Ala Ile 
                645                 650                 655     


Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Val Thr Ala Phe Glu 
            660                 665                 670         


Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe His 
        675                 680                 685             


Arg Lys Ala Glu Asp Ile Glu Asn Asp Ala Leu Ser Pro Glu Glu Gln 
    690                 695                 700                 


Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr Arg Asp Tyr Leu Ile Lys 
705                 710                 715                 720 


Ile Ile Asp Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu Pro 
                725                 730                 735     


Val Pro Leu Glu Ser Val Lys Glu Met Leu Asn Ser Val Met Gln Glu 
            740                 745                 750         


Leu Glu Asp Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser Leu 
        755                 760                 765             


Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr Arg 
    770                 775                 780                 


Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Lys Thr Pro 
785                 790                 795                 800 


Pro Arg Trp Ala Glu Asp Gln Asn Ser Leu Leu Lys Met Ile Cys Gln 
                805                 810                 815     


Gln Val Glu Ala Ile Lys Lys Glu Met Gln Glu Leu Lys Leu Asn Ser 
            820                 825                 830         


Ser Asn Ser Ala Ser Pro His Arg Trp Pro Thr Glu Asn Tyr Gly Pro 
        835                 840                 845             


Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly Ala 
    850                 855                 860                 


Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln Ser 
865                 870                 875                 880 


Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val Thr 
                885                 890                 895     


Pro Thr Lys Gly Pro Val Tyr Gly Met Asn Arg Leu Pro Pro Gln Gln 
            900                 905                 910         


His Ile Tyr Ala Tyr Pro Gln Gln Met His Thr Pro Pro Val Gln Ser 
        915                 920                 925             


Ser Ser Ala Cys Met Phe Ser Gln Glu Met Tyr Gly Pro Pro Ala Leu 
    930                 935                 940                 


Arg Phe Glu Ser Pro Ala Thr Gly Ile Leu Ser Pro Arg Gly Asp Asp 
945                 950                 955                 960 


Tyr Phe Asn Tyr Asn Val Gln Gln Thr Ser Thr Asn Pro Pro Leu Pro 
                965                 970                 975     


Glu Pro Gly Tyr Phe Thr Lys Pro Pro Ile Ala Ala His Ala Ser Arg 
            980                 985                 990         


Ser Ala Glu Ser Lys Thr Ile Glu  Phe Gly Lys Thr Asn  Phe Val Gln 
        995                 1000                 1005             


Pro Met  Pro Gly Glu Gly Leu  Arg Pro Ser Leu Pro  Thr Gln Ala 
    1010                 1015                 1020             


His Thr  Thr Gln Pro Thr Pro  Phe Lys Phe Asn Ser  Asn Phe Lys 
    1025                 1030                 1035             


Ser Asn  Asp Gly Asp Phe Thr  Phe Ser Ser Pro Gln  Val Val Thr 
    1040                 1045                 1050             


Gln Pro  Pro Pro Ala Ala Tyr  Ser Asn Ser Glu Ser  Leu Leu Gly 
    1055                 1060                 1065             


Leu Leu  Thr Ser Asp Lys Pro  Leu Gln Gly Asp Gly  Tyr Ser Gly 
    1070                 1075                 1080             


Ala Lys  Pro Ile Pro Gly Gly  Gln Thr Ile Gly Pro  Arg Asn Thr 
    1085                 1090                 1095             


Phe Asn  Phe Gly Ser Lys Asn  Val Ser Gly Ile Ser  Phe Thr Glu 
    1100                 1105                 1110             


Asn Met  Gly Ser Ser Gln Gln  Lys Asn Ser Gly Phe  Arg Arg Ser 
    1115                 1120                 1125             


Asp Asp  Met Phe Thr Phe His  Gly Pro Gly Lys Ser  Val Phe Gly 
    1130                 1135                 1140             


Thr Pro  Thr Leu Glu Thr Ala  Asn Lys Asn His Glu  Thr Asp Gly 
    1145                 1150                 1155             


Gly Ser  Ala His Gly Asp Asp  Asp Asp Asp Gly Pro  His Phe Glu 
    1160                 1165                 1170             


Pro Val  Val Pro Leu Pro Asp  Lys Ile Glu Val Lys  Thr Gly Glu 
    1175                 1180                 1185             


Glu Asp  Glu Glu Glu Phe Phe  Cys Asn Arg Ala Lys  Leu Phe Arg 
    1190                 1195                 1200             


Phe Asp  Val Glu Ser Lys Glu  Trp Lys Glu Arg Gly  Ile Gly Asn 
    1205                 1210                 1215             


Val Lys  Ile Leu Arg His Lys  Thr Ser Gly Lys Ile  Arg Leu Leu 
    1220                 1225                 1230             


Met Arg  Arg Glu Gln Val Leu  Lys Ile Cys Ala Asn  His Tyr Ile 
    1235                 1240                 1245             


Ser Pro  Asp Met Lys Leu Thr  Pro Asn Ala Gly Ser  Asp Arg Ser 
    1250                 1255                 1260             


Phe Val  Trp His Ala Leu Asp  Tyr Ala Asp Glu Leu  Pro Lys Pro 
    1265                 1270                 1275             


Glu Gln  Leu Ala Ile Arg Phe  Lys Thr Pro Glu Glu  Ala Ala Leu 
    1280                 1285                 1290             


Phe Lys  Cys Lys Phe Glu Glu  Ala Gln Ser Ile Leu  Lys Ala Pro 
    1295                 1300                 1305             


Gly Thr  Asn Val Ala Met Ala  Ser Asn Gln Ala Val  Arg Ile Val 
    1310                 1315                 1320             


Lys Glu  Pro Thr Ser His Asp  Asn Lys Asp Ile Cys  Lys Ser Asp 
    1325                 1330                 1335             


Ala Gly  Asn Leu Asn Phe Glu  Phe Gln Val Ala Lys  Lys Glu Gly 
    1340                 1345                 1350             


Ser Trp  Trp His Cys Asn Ser  Cys Ser Leu Lys Asn  Ala Ser Thr 
    1355                 1360                 1365             


Ala Lys  Lys Cys Val Ser Cys  Gln Asn Leu Asn Pro  Ser Asn Lys 
    1370                 1375                 1380             


Glu Leu  Val Gly Pro Pro Leu  Ala Glu Thr Val Phe  Thr Pro Lys 
    1385                 1390                 1395             


Thr Ser  Pro Glu Asn Val Gln  Asp Arg Phe Ala Leu  Val Thr Pro 
    1400                 1405                 1410             


Lys Lys  Glu Gly His Trp Asp  Cys Ser Ile Cys Leu  Val Arg Asn 
    1415                 1420                 1425             


Glu Pro  Thr Val Ser Arg Cys  Ile Ala Cys Gln Asn  Thr Lys Ser 
    1430                 1435                 1440             


Ala Asn  Lys Ser Gly Ser Ser  Phe Val His Gln Ala  Ser Phe Lys 
    1445                 1450                 1455             


Phe Gly  Gln Gly Asp Leu Pro  Lys Pro Ile Asn Ser  Asp Phe Arg 
    1460                 1465                 1470             


Ser Val  Phe Ser Thr Lys Glu  Gly Gln Trp Asp Cys  Ser Ala Cys 
    1475                 1480                 1485             


Leu Val  Gln Asn Glu Gly Ser  Ser Thr Lys Cys Ala  Ala Cys Gln 
    1490                 1495                 1500             


Asn Pro  Arg Lys Gln Ser Leu  Pro Ala Thr Ser Ile  Pro Thr Pro 
    1505                 1510                 1515             


Ala Ser  Phe Lys Phe Gly Thr  Ser Glu Thr Ser Lys  Thr Leu Lys 
    1520                 1525                 1530             


Ser Gly  Phe Glu Asp Met Phe  Ala Lys Lys Glu Gly  Gln Trp Asp 
    1535                 1540                 1545             


Cys Ser  Ser Cys Leu Val Arg  Asn Glu Ala Asn Ala  Thr Arg Cys 
    1550                 1555                 1560             


Val Ala  Cys Gln Asn Pro Asp  Lys Pro Ser Pro Ser  Thr Ser Val 
    1565                 1570                 1575             


Pro Ala  Pro Ala Ser Phe Lys  Phe Gly Thr Ser Glu  Thr Ser Lys 
    1580                 1585                 1590             


Ala Pro  Lys Ser Gly Phe Glu  Gly Met Phe Thr Lys  Lys Glu Gly 
    1595                 1600                 1605             


Gln Trp  Asp Cys Ser Val Cys  Leu Val Arg Asn Glu  Ala Ser Ala 
    1610                 1615                 1620             


Thr Lys  Cys Ile Ala Cys Gln  Asn Pro Gly Lys Gln  Asn Gln Thr 
    1625                 1630                 1635             


Thr Ser  Ala Val Ser Thr Pro  Ala Ser Ser Glu Thr  Ser Lys Ala 
    1640                 1645                 1650             


Pro Lys  Ser Gly Phe Glu Gly  Met Phe Thr Lys Lys  Glu Gly Gln 
    1655                 1660                 1665             


Trp Asp  Cys Ser Val Cys Leu  Val Arg Asn Glu Ala  Ser Ala Thr 
    1670                 1675                 1680             


Lys Cys  Ile Ala Cys Gln Asn  Pro Gly Lys Gln Asn  Gln Thr Thr 
    1685                 1690                 1695             


Ser Ala  Val Ser Thr Pro Ala  Ser Ser Glu Thr Ser  Lys Ala Pro 
    1700                 1705                 1710             


Lys Ser  Gly Phe Glu Gly Met  Phe Thr Lys Lys Glu  Gly Gln Trp 
    1715                 1720                 1725             


Asp Cys  Ser Val Cys Leu Val  Arg Asn Glu Ala Ser  Ala Thr Lys 
    1730                 1735                 1740             


Cys Ile  Ala Cys Gln Cys Pro  Ser Lys Gln Asn Gln  Thr Thr Ala 
    1745                 1750                 1755             


Ile Ser  Thr Pro Ala Ser Ser  Glu Ile Ser Lys Ala  Pro Lys Ser 
    1760                 1765                 1770             


Gly Phe  Glu Gly Met Phe Ile  Arg Lys Gly Gln Trp  Asp Cys Ser 
    1775                 1780                 1785             


Val Cys  Cys Val Gln Asn Glu  Ser Ser Ser Leu Lys  Cys Val Ala 
    1790                 1795                 1800             


Cys Asp  Ala Ser Lys Pro Thr  His Lys Pro Ile Ala  Glu Ala Pro 
    1805                 1810                 1815             


Ser Ala  Phe Thr Leu Gly Ser  Glu Met Lys Leu His  Asp Ser Ser 
    1820                 1825                 1830             


Gly Ser  Gln Val Gly Thr Gly  Phe Lys Ser Asn Phe  Ser Glu Lys 
    1835                 1840                 1845             


Ala Ser  Lys Phe Gly Asn Thr  Glu Gln Gly Phe Lys  Phe Gly His 
    1850                 1855                 1860             


Val Asp  Gln Glu Asn Ser Pro  Ser Phe Met Phe Gln  Gly Ser Ser 
    1865                 1870                 1875             


Asn Thr  Glu Phe Lys Ser Thr  Lys Glu Gly Phe Ser  Ile Pro Val 
    1880                 1885                 1890             


Ser Ala  Asp Gly Phe Lys Phe  Gly Ile Ser Glu Pro  Gly Asn Gln 
    1895                 1900                 1905             


Glu Lys  Lys Ser Glu Lys Pro  Leu Glu Asn Gly Thr  Gly Phe Gln 
    1910                 1915                 1920             


Ala Gln  Asp Ile Ser Gly Gln  Lys Asn Gly Arg Gly  Val Ile Phe 
    1925                 1930                 1935             


Gly Gln  Thr Ser Ser Thr Phe  Thr Phe Ala Asp Leu  Ala Lys Ser 
    1940                 1945                 1950             


Thr Ser  Gly Glu Gly Phe Gln  Phe Gly Lys Lys Asp  Pro Asn Phe 
    1955                 1960                 1965             


Lys Gly  Phe Ser Gly Ala Gly  Glu Lys Leu Phe Ser  Ser Gln Tyr 
    1970                 1975                 1980             


Gly Lys  Met Ala Asn Lys Ala  Asn Thr Ser Gly Asp  Phe Glu Lys 
    1985                 1990                 1995             


Asp Asp  Asp Ala Tyr Lys Thr  Glu Asp Ser Asp Asp  Ile His Phe 
    2000                 2005                 2010             


Glu Pro  Val Val Gln Met Pro  Glu Lys Val Glu Leu  Val Thr Gly 
    2015                 2020                 2025             


Glu Glu  Asp Glu Lys Val Leu  Tyr Ser Gln Arg Val  Lys Leu Phe 
    2030                 2035                 2040             


Arg Phe  Asp Ala Glu Val Ser  Gln Trp Lys Glu Arg  Gly Leu Gly 
    2045                 2050                 2055             


Asn Leu  Lys Ile Leu Lys Asn  Glu Val Asn Gly Lys  Leu Arg Met 
    2060                 2065                 2070             


Leu Met  Arg Arg Glu Gln Val  Leu Lys Val Cys Ala  Asn His Trp 
    2075                 2080                 2085             


Ile Thr  Thr Thr Met Asn Leu  Lys Pro Leu Ser Gly  Ser Asp Arg 
    2090                 2095                 2100             


Ala Trp  Met Trp Leu Ala Ser  Asp Phe Ser Asp Gly  Asp Ala Lys 
    2105                 2110                 2115             


Leu Glu  Gln Leu Ala Ala Lys  Phe Lys Thr Pro Glu  Leu Ala Glu 
    2120                 2125                 2130             


Glu Phe  Lys Gln Lys Phe Glu  Glu Cys Gln Arg Leu  Leu Leu Asp 
    2135                 2140                 2145             


Ile Pro  Leu Gln Thr Pro His  Lys Leu Val Asp Thr  Gly Arg Ala 
    2150                 2155                 2160             


Ala Lys  Leu Ile Gln Arg Ala  Glu Glu Met Lys Ser  Gly Leu Lys 
    2165                 2170                 2175             


Asp Phe  Lys Thr Phe Leu Thr  Asn Asp Gln Thr Lys  Val Thr Glu 
    2180                 2185                 2190             


Glu Glu  Asn Lys Gly Ser Gly  Thr Gly Ala Ala Gly  Ala Ser Asp 
    2195                 2200                 2205             


Thr Thr  Ile Lys Pro Asn Pro  Glu Asn Thr Gly Pro  Thr Leu Glu 
    2210                 2215                 2220             


Trp Asp  Asn Tyr Asp Leu Arg  Glu Asp Ala Leu Asp  Asp Ser Val 
    2225                 2230                 2235             


Ser Ser  Ser Ser Val His Ala  Ser Pro Leu Ala Ser  Ser Pro Val 
    2240                 2245                 2250             


Arg Lys  Asn Leu Phe Arg Phe  Gly Glu Ser Thr Thr  Gly Phe Asn 
    2255                 2260                 2265             


Phe Ser  Phe Lys Ser Ala Leu  Ser Pro Ser Lys Ser  Pro Ala Lys 
    2270                 2275                 2280             


Leu Asn  Gln Ser Gly Thr Ser  Val Gly Thr Asp Glu  Glu Ser Asp 
    2285                 2290                 2295             


Val Thr  Gln Glu Glu Glu Arg  Asp Gly Gln Tyr Phe  Glu Pro Val 
    2300                 2305                 2310             


Val Pro  Leu Pro Asp Leu Val  Glu Val Ser Ser Gly  Glu Glu Asn 
    2315                 2320                 2325             


Glu Gln  Val Val Phe Ser His  Arg Ala Lys Leu Tyr  Arg Tyr Asp 
    2330                 2335                 2340             


Lys Asp  Val Gly Gln Trp Lys  Glu Arg Gly Ile Gly  Asp Ile Lys 
    2345                 2350                 2355             


Ile Leu  Gln Asn Tyr Asp Asn  Lys Gln Val Arg Ile  Val Met Arg 
    2360                 2365                 2370             


Arg Asp  Gln Val Leu Lys Leu  Cys Ala Asn His Arg  Ile Thr Pro 
    2375                 2380                 2385             


Asp Met  Thr Leu Gln Asn Met  Lys Gly Thr Glu Arg  Val Trp Leu 
    2390                 2395                 2400             


Trp Thr  Ala Cys Asp Phe Ala  Asp Gly Glu Arg Lys  Val Glu His 
    2405                 2410                 2415             


Leu Ala  Val Arg Phe Lys Leu  Gln Asp Val Ala Asp  Ser Phe Lys 
    2420                 2425                 2430             


Lys Ile  Phe Asp Glu Ala Lys  Thr Ala Gln Glu Lys  Asp Ser Leu 
    2435                 2440                 2445             


Ile Thr  Pro His Val Ser Arg  Ser Ser Thr Pro Arg  Glu Ser Pro 
    2450                 2455                 2460             


Cys Gly  Lys Ile Ala Val Ala  Val Leu Glu Glu Thr  Thr Arg Glu 
    2465                 2470                 2475             


Arg Thr  Asp Val Ile Gln Gly  Asp Asp Val Ala Asp  Ala Thr Ser 
    2480                 2485                 2490             


Glu Val  Glu Val Ser Ser Thr  Ser Glu Thr Thr Pro  Lys Ala Val 
    2495                 2500                 2505             


Val Ser  Pro Pro Lys Phe Val  Phe Gly Ser Glu Ser  Val Lys Ser 
    2510                 2515                 2520             


Ile Phe  Ser Ser Glu Lys Ser  Lys Pro Phe Ala Phe  Gly Asn Ser 
    2525                 2530                 2535             


Ser Ala  Thr Gly Ser Leu Phe  Gly Phe Ser Phe Asn  Ala Pro Leu 
    2540                 2545                 2550             


Lys Ser  Asn Asn Ser Glu Thr  Ser Ser Val Ala Gln  Ser Gly Ser 
    2555                 2560                 2565             


Glu Ser  Lys Val Glu Pro Lys  Lys Cys Glu Leu Ser  Lys Asn Ser 
    2570                 2575                 2580             


Asp Ile  Glu Gln Ser Ser Asp  Ser Lys Val Lys Asn  Leu Phe Ala 
    2585                 2590                 2595             


Ser Phe  Pro Thr Glu Glu Ser  Ser Ile Asn Tyr Thr  Phe Lys Thr 
    2600                 2605                 2610             


Pro Glu  Lys Ala Lys Glu Lys  Lys Lys Pro Glu Asp  Ser Pro Ser 
    2615                 2620                 2625             


Asp Asp  Asp Val Leu Ile Val  Tyr Glu Leu Thr Pro  Thr Ala Glu 
    2630                 2635                 2640             


Gln Lys  Ala Leu Ala Thr Lys  Leu Lys Leu Pro Pro  Thr Phe Phe 
    2645                 2650                 2655             


Cys Tyr  Lys Asn Arg Pro Asp  Tyr Val Ser Glu Glu  Glu Glu Asp 
    2660                 2665                 2670             


Asp Glu  Asp Phe Glu Thr Ala  Val Lys Lys Leu Asn  Gly Lys Leu 
    2675                 2680                 2685             


Tyr Leu  Asp Gly Ser Glu Lys  Cys Arg Pro Leu Glu  Glu Asn Thr 
    2690                 2695                 2700             


Ala Asp  Asn Glu Lys Glu Cys  Ile Ile Val Trp Glu  Lys Lys Pro 
    2705                 2710                 2715             


Thr Val  Glu Glu Lys Ala Lys  Ala Asp Thr Leu Lys  Leu Pro Pro 
    2720                 2725                 2730             


Thr Phe  Phe Cys Gly Val Cys  Ser Asp Thr Asp Glu  Asp Asn Gly 
    2735                 2740                 2745             


Asn Gly  Glu Asp Phe Gln Ser  Glu Leu Gln Lys Val  Gln Glu Ala 
    2750                 2755                 2760             


Gln Lys  Ser Gln Thr Glu Glu  Ile Thr Ser Thr Thr  Asp Ser Val 
    2765                 2770                 2775             


Tyr Thr  Gly Gly Thr Glu Val  Met Val Pro Ser Phe  Cys Lys Ser 
    2780                 2785                 2790             


Glu Glu  Pro Asp Ser Ile Thr  Lys Ser Ile Ser Ser  Pro Ser Val 
    2795                 2800                 2805             


Ser Ser  Glu Thr Met Asp Lys  Pro Val Asp Leu Ser  Thr Arg Lys 
    2810                 2815                 2820             


Glu Ile  Asp Thr Asp Ser Thr  Ser Gln Gly Glu Ser  Lys Ile Val 
    2825                 2830                 2835             


Ser Phe  Gly Phe Gly Ser Ser  Thr Gly Leu Ser Phe  Ala Asp Leu 
    2840                 2845                 2850             


Ala Ser  Ser Asn Ser Gly Asp  Phe Ala Phe Gly Ser  Lys Asp Lys 
    2855                 2860                 2865             


Asn Phe  Gln Trp Ala Asn Thr  Gly Ala Ala Val Phe  Gly Thr Gln 
    2870                 2875                 2880             


Ser Val  Gly Thr Gln Ser Ala  Gly Lys Val Gly Glu  Asp Glu Asp 
    2885                 2890                 2895             


Gly Ser  Asp Glu Glu Val Val  His Asn Glu Asp Ile  His Phe Glu 
    2900                 2905                 2910             


Pro Ile  Val Ser Leu Pro Glu  Val Glu Val Lys Ser  Gly Glu Glu 
    2915                 2920                 2925             


Asp Glu  Glu Ile Leu Phe Lys  Glu Arg Ala Lys Leu  Tyr Arg Trp 
    2930                 2935                 2940             


Asp Arg  Asp Val Ser Gln Trp  Lys Glu Arg Gly Val  Gly Asp Ile 
    2945                 2950                 2955             


Lys Ile  Leu Trp His Thr Met  Lys Asn Tyr Tyr Arg  Ile Leu Met 
    2960                 2965                 2970             


Arg Arg  Asp Gln Val Phe Lys  Val Cys Ala Asn His  Val Ile Thr 
    2975                 2980                 2985             


Lys Thr  Met Glu Leu Lys Pro  Leu Asn Val Ser Asn  Asn Ala Leu 
    2990                 2995                 3000             


Val Trp  Thr Ala Ser Asp Tyr  Ala Asp Gly Glu Ala  Lys Val Glu 
    3005                 3010                 3015             


Gln Leu  Ala Val Arg Phe Lys  Thr Lys Glu Val Ala  Asp Cys Phe 
    3020                 3025                 3030             


Lys Lys  Thr Phe Glu Glu Cys  Gln Gln Asn Leu Met  Lys Leu Gln 
    3035                 3040                 3045             


Lys Gly  His Val Ser Leu Ala  Ala Glu Leu Ser Lys  Glu Thr Asn 
    3050                 3055                 3060             


Pro Val  Val Phe Phe Asp Val  Cys Ala Asp Gly Glu  Pro Leu Gly 
    3065                 3070                 3075             


Arg Ile  Thr Met Glu Leu Phe  Ser Asn Ile Val Pro  Arg Thr Ala 
    3080                 3085                 3090             


Glu Asn  Phe Arg Ala Leu Cys  Thr Gly Glu Lys Gly  Phe Gly Phe 
    3095                 3100                 3105             


Lys Asn  Ser Ile Phe His Arg  Val Ile Pro Asp Phe  Val Cys Gln 
    3110                 3115                 3120             


Gly Gly  Asp Ile Thr Lys His  Asp Gly Thr Gly Gly  Gln Ser Ile 
    3125                 3130                 3135             


Tyr Gly  Asp Lys Phe Glu Asp  Glu Asn Phe Asp Val  Lys His Thr 
    3140                 3145                 3150             


Gly Pro  Gly Leu Leu Ser Met  Ala Asn Gln Gly Gln  Asn Thr Asn 
    3155                 3160                 3165             


Asn Ser  Gln Phe Val Ile Thr  Leu Lys Lys Ala Glu  His Leu Asp 
    3170                 3175                 3180             


Phe Lys  His Val Val Phe Gly  Phe Val Lys Asp Gly  Met Asp Thr 
    3185                 3190                 3195             


Val Lys  Lys Ile Glu Ser Phe  Gly Ser Pro Lys Gly  Ser Val Cys 
    3200                 3205                 3210             


Arg Arg  Ile Thr Ile Thr Glu  Cys Gly Gln Ile 
    3215                 3220                 


<210>  8211
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  8211
cacagtggtc ctccgccggc tacggcgctg cgtcactggt ttgcaggcgc tttcctcttg     60

gaagtggcga ctgctgcggg cctgagcgct ggtctcacgc gcctcgggag ccaggttggc    120

ggcgcgatga ggcgcagcaa ggctgacgtg gagcggtaca tcgcctcggt gcagggctcc    180

accccgtcgc ctcgacagaa gtcaatgaaa ggattctatt ttgcaaagct gtattatgaa    240

gctaaagaat atgatcttgc taaaaaatac atatgtactt acattaatgt gcaagagagg    300

gatcccaaag ctcacagatt tctgggtctt ctttatgaat tggaagaaaa cacagacaaa    360

gccgttgaat gttacaggcg ttcagtggaa ttaaacccaa cacaaaaaga tcttgtgttg    420

aagattgcag aattgctttg taaaaatgat gttactgatg gaagagcaaa atactggctt    480

gaaagagcag ccaaactttt cccaggaagt cctgcaattt ataaactaaa ggaacagctt    540

ctagattgtg aaggtgaaga tggatggaat aaactttttg acttgattca gtcagaactt    600

tatgtaagac ctgatgacgt ccatgtgaac atccggctag tggaggtgta tcgctcaact    660

aaaagattga aggatgctgt ggcccactgc catgaggcag agaggaacat agctttgcgt    720

tcaagtttag aatggaattc gtgtgttgta cagaccctta aggaatatct ggagtcttta    780

cagtgtttgg agtctgataa aagtgactgg cgagcaacca atacagactt actgctggcc    840

tatgctaatc ttatgcttct tacgctttcc actagagatg tgcaggaaag tagagaatta    900

ctgcaaagtt ttgatagtgc tcttcagtct gtgaaatctt tgggtggaaa tgatgaactg    960

tcagctactt tcttagaaat gaaaggacat ttctacatgc atgctggttc tctgcttttg   1020

aagatgggtc agcatagtag taatgttcaa tggcgagctc tttctgagct ggctgcattg   1080

tgctatctca tagcatttca ggttccaaga ccaaagatta aattaataaa aggtgaagct   1140

ggacaaaatc tgctggaaat gatggcctgt gaccgactga gccaatcagg gcacatgttg   1200

ctaaacttaa gtcgtggcaa gcaagatttt ttaaaagaga ttgttgaaac ttttgccaac   1260

aaaagcgggc agtctgcatt atatgatgct ctgttttcta gtcagtcacc taaggataca   1320

tcttttcttg gtagcgatga tattggaaac attgatgtac gagaaccaga gcttgaagat   1380

ttgactagat acgatgttgg tgctattcga gcacataatg gtagtcttca gcaccttact   1440

tggcttggct tacagtggaa ttcattgcct gctttacctg gaatccgaaa atggctaaaa   1500

cagcttttcc atcatttgcc ccatgaaacc tcaaggcttg aaacaaatgc acctgaatca   1560

atatgtattt tagatcttga agtatttctc cttggagtag tatataccag ccacttacaa   1620

ttaaaggaga aatgtaattc tcaccacagc tcctatcagc cgttatgcct gccccttcct   1680

gtgtgtaaac agctttgtac agaaagacaa aaatcttggt gggatgcggt ttgtactctg   1740

attcacagaa aagcagtacc tggaaacgta gcaaaattga gacttctagt tcagcatgaa   1800

ataaacactc taagagccca ggaaaaacat ggccttcaac ctgctctgct tgtacattgg   1860

gcagaatgcc ttcagaaaac gggcagcggt cttaattctt tttatgatca acgagaatac   1920

atagggagaa gtgttcatta ttggaagaaa gttttgccat tgttgaagat aataaaaaag   1980

aagaacagta ttcctgaacc tattgatcct ctgtttaaac attttcatag tgtagacatt   2040

caggcatcag aaattgttga atatgaagaa gacgcacaca taacttttgc tatattggat   2100

gcagtaaatg gaaatataga agatgctgtg actgcttttg aatctataaa aagtgttgtt   2160

tcttattgga atcttgcact gatttttcac aggaaggcag aagacattga aaatgatgcc   2220

ctttctcctg aagaacaaga agaatgcaaa aattatctga gaaagaccag ggactaccta   2280

ataaagatta tagatgacag tgattcaaat ctttcagtgg tcaagaaatt gcctgtgccc   2340

ctggagtctg taaaagagat gcttaattca gtcatgcagg aactcgaaga ctatagtgaa   2400

ggaggtcctc tctataaaaa tggttctttg cgaaatgcag attcagaaat aaaacattct   2460

acaccgtctc ctaccagata ttcactatca ccaagtaaaa gttacaagta ttctcccaaa   2520

acaccacctc gatgggcaga agatcagaat tctttactga aaatgatttg ccaacaagta   2580

gaggccatta agaaagaaat gcaggagttg aaactaaata gcagtaactc agcatcccct   2640

catcgttggc ccacagagaa ttatggacca gactcagtgc ctgatggata tcaggggtca   2700

cagacatttc atggggctcc actaacagtt gcaactactg gcccttcagt atattatagt   2760

cagtcaccag catataattc ccagtatctt ctcagaccag cagctaatgt tactcccaca   2820

aagggcccag tctatggcat gaataggctt ccaccccaac agcatattta tgcctatccg   2880

caacagatgc acacaccgcc agtgcaaagc tcatctgctt gtatgttctc tcaggagatg   2940

tatggtcctc ctgcattgcg ttttgagtct cctgcaacgg gaattctatc gcccaggggt   3000

gatgattact ttaattacaa tgttcaacag acaagcacaa atccaccttt gccagaacca   3060

ggatatttca caaaacctcc gattgcagct catgcttcaa gatctgcaga atctaagact   3120

atagaatttg ggaaaactaa ttttgttcag cccatgccgg gtgaaggatt aaggccatct   3180

ttgccaacac aagcacacac aacacagcca actcctttta aatttaactc aaatttcaaa   3240

tcaaatgatg gtgacttcac gttttcctca ccacaggttg tgacacagcc ccctcctgca   3300

gcttacagta acagtgaaag ccttttaggt ctcctgactt cagataaacc cttgcaagga   3360

gatggctata gtggagccaa accaattcct ggtggtcaaa ccattgggcc tcgaaataca   3420

ttcaattttg gaagcaaaaa tgtgtctgga atttcattta cagaaaacat ggggtcgagt   3480

cagcaaaaga attctggttt tcggcgaagt gatgatatgt ttactttcca tggtccaggg   3540

aaatcagtat ttggaacacc cactttagag acagcaaaca agaatcatga gacagatgga   3600

ggaagtgccc atggggatga tgatgatgac ggtcctcact ttgagcctgt agtacctctt   3660

cctgataaga ttgaagtaaa aactggtgag gaagatgaag aagaattctt ttgcaaccgc   3720

gcgaaattgt ttcgtttcga tgtagaatcc aaagaatgga aagaacgtgg gattggcaat   3780

gtaaaaatac tgaggcataa aacatctggt aaaattcgcc ttctaatgag acgagagcaa   3840

gtattgaaaa tctgtgcaaa tcattacatc agtccagata tgaaattgac accaaatgct   3900

ggatcagaca gatcttttgt atggcatgcc cttgattatg cagatgagtt gccaaaacca   3960

gaacaacttg ctattaggtt caaaactcct gaggaagcag cactttttaa atgcaagttt   4020

gaagaagccc agagcatttt aaaagcccca ggaacaaatg tagccatggc gtcaaatcag   4080

gctgtcagaa ttgtaaaaga acccacaagt catgataaca aggatatttg caaatctgat   4140

gctggaaacc tgaattttga atttcaggtt gcaaagaaag aagggtcttg gtggcattgt   4200

aacagctgct cattaaagaa tgcttcaact gctaagaaat gtgtatcatg ccaaaatcta   4260

aacccaagca ataaagagct cgttggccca ccattagctg aaactgtttt tactcctaaa   4320

accagcccag agaatgttca agatcgattt gcattggtga ctccaaagaa agaaggtcac   4380

tgggattgta gtatttgttt agtaagaaat gaacctactg tatctaggtg cattgcgtgt   4440

cagaatacaa aatctgctaa caaaagtgga tcttcatttg ttcatcaagc ttcatttaaa   4500

tttggccagg gagatcttcc taaacctatt aacagtgatt tcagatctgt tttttctaca   4560

aaggaaggac agtgggattg cagtgcatgt ttggtacaaa atgaggggag ctctacaaaa   4620

tgtgctgctt gtcagaatcc gagaaaacag agtctacctg ctacttctat tccaacacct   4680

gcctctttta agtttggtac ttcagagaca agtaaaactc taaaaagtgg atttgaagac   4740

atgtttgcta agaaggaagg acagtgggat tgcagttcat gcttagtgcg aaatgaagca   4800

aatgctacaa gatgtgttgc ttgtcagaat ccggataaac caagtccatc tacttctgtt   4860

ccagctcctg cctcttttaa gtttggtact tcagagacaa gcaaggctcc aaagagcgga   4920

tttgagggaa tgttcactaa gaaggaggga cagtgggatt gcagtgtgtg cttagtaaga   4980

aatgaagcca gtgctaccaa atgtattgct tgtcagaatc caggtaaaca aaatcaaact   5040

acttctgcag tttcaacacc tgcctcttca gagacaagca aggctccaaa gagcggattt   5100

gagggaatgt tcactaagaa ggagggacag tgggattgca gtgtgtgctt agtaagaaat   5160

gaagccagtg ctaccaaatg tattgcttgt cagaatccag gtaaacaaaa tcaaactact   5220

tctgcagttt caacacctgc ctcttcagag acaagcaagg ctccaaagag cggatttgag   5280

ggaatgttca ctaagaagga aggacagtgg gattgcagtg tgtgcttagt aagaaatgaa   5340

gccagtgcta ccaaatgtat tgcttgtcag tgtccaagta aacaaaatca aacaactgca   5400

atttcaacac ctgcctcttc ggagataagc aaggctccaa agagtggatt tgaaggaatg   5460

ttcatcagga aaggacagtg ggattgtagt gtttgctgtg tacaaaatga gagttcttcc   5520

ttaaaatgtg tggcttgtga tgcctctaaa ccaactcata aacctattgc agaagctcct   5580

tcagctttca cactgggctc agaaatgaag ttgcatgact cttctggaag tcaggtggga   5640

acaggattta aaagtaattt ctcagaaaaa gcttctaagt ttggcaatac agagcaagga   5700

ttcaaatttg ggcatgtgga tcaagaaaat tcaccttcat ttatgtttca gggttcttct   5760

aatacagaat ttaagtcaac caaagaagga ttttccatcc ctgtgtctgc tgatggattt   5820

aaatttggca tttcggaacc aggaaatcaa gaaaagaaaa gtgaaaagcc tcttgaaaat   5880

ggtactggct tccaggctca ggatattagt ggccagaaga atggccgtgg tgtgattttt   5940

ggccaaacaa gtagcacttt tacatttgca gatcttgcaa aatcaacttc aggagaagga   6000

tttcagtttg gcaaaaaaga ccccaatttc aagggatttt caggtgctgg agaaaaatta   6060

ttctcatcac aatacggtaa aatggccaat aaagcaaaca cttccggtga ctttgagaaa   6120

gatgatgatg cctataagac tgaggacagc gatgacatcc attttgaacc agtagttcaa   6180

atgcccgaaa aagtagaact tgtaacagga gaagaagatg aaaaagttct gtattcacag   6240

cgggtaaaac tatttagatt tgatgctgag gtaagtcagt ggaaagaaag gggcttgggg   6300

aacttaaaaa ttctcaaaaa cgaggtcaat ggcaaactaa gaatgctgat gcgaagagaa   6360

caagtactaa aagtgtgtgc taatcattgg ataacgacta cgatgaacct gaagcctctc   6420

tctggatcag atagagcatg gatgtggtta gccagtgatt tctctgatgg tgatgccaaa   6480

ctagagcagt tggcagcaaa atttaaaaca ccagagctgg ctgaagaatt caagcagaaa   6540

tttgaggaat gccagcggct tctgttagac ataccacttc aaactcccca taaacttgta   6600

gatactggca gagctgccaa gttaatacag agagctgaag aaatgaagag tggactgaaa   6660

gatttcaaaa catttttgac aaatgatcaa acaaaagtca ctgaggaaga aaataagggt   6720

tcaggtacag gtgcggccgg tgcctcagac acaacaataa aacccaatcc tgaaaacact   6780

gggcccacat tagaatggga taactatgat ttaagggaag atgctttgga tgatagtgtc   6840

agtagtagct cagtacatgc ttctccattg gcaagtagcc ctgtgagaaa aaatcttttc   6900

cgttttggtg agtcaacaac aggatttaac ttcagtttta aatctgcttt gagtccatct   6960

aagtctcctg ccaagttgaa tcagagtggg acttcagttg gcactgatga agaatctgat   7020

gttactcaag aagaagagag agatggacag tactttgaac ctgttgttcc tttacctgat   7080

ctagttgaag tatccagtgg tgaggaaaat gaacaagttg tttttagtca cagggcaaaa   7140

ctctacagat atgataaaga tgttggtcaa tggaaagaaa ggggcattgg tgatataaag   7200

attttacaga attatgataa taagcaagtt cgtatagtga tgagaaggga ccaagtatta   7260

aaactttgtg ccaatcacag aataactcca gacatgactt tgcaaaatat gaaagggaca   7320

gaaagagtat ggttgtggac tgcatgtgat tttgcagatg gagaaagaaa agtagagcat   7380

ttagctgttc gttttaaact acaggatgtt gcagactcgt ttaagaaaat ttttgatgaa   7440

gcaaaaacag cccaggaaaa agattctttg ataacacctc atgtttctcg gtcaagcact   7500

cccagagagt caccatgtgg caaaattgct gtagctgtat tagaagaaac cacaagagag   7560

aggacagatg ttattcaggg tgatgatgta gcagatgcaa cttcagaagt tgaagtgtct   7620

agcacatctg aaacaacacc aaaagcagtg gtttctcctc caaagtttgt atttggttca   7680

gagtctgtta aaagcatttt tagtagtgaa aaatcaaaac catttgcatt cggcaacagt   7740

tcagccactg ggtctttgtt tggatttagt tttaatgcac ctttgaaaag taacaatagt   7800

gaaactagtt cagtagccca gagtggatct gaaagcaaag tggaacctaa aaaatgtgaa   7860

ctgtcaaaga actctgatat cgaacagtct tcagatagca aagtcaaaaa tctctttgct   7920

tcctttccaa cggaagaatc ttcaatcaac tacacattta aaacaccaga aaaggcaaaa   7980

gagaagaaaa aacctgaaga ttctccctca gatgatgatg ttctcattgt atatgaacta   8040

actccaaccg ctgagcagaa agcccttgca accaaactta aacttcctcc aactttcttc   8100

tgctacaaga atagaccaga ttatgttagt gaagaagagg aggatgatga agatttcgaa   8160

acagctgtca agaaacttaa tggaaaacta ta                                 8192


<210>  8212
<211>  3224
<212>  PRT
<213>  Homosapiens

<400>  8212

Met Arg Arg Ser Lys Ala Asp Val Glu Arg Tyr Ile Ala Ser Val Gln 
1               5                   10                  15      


Gly Ser Thr Pro Ser Pro Arg Gln Lys Ser Met Lys Gly Phe Tyr Phe 
            20                  25                  30          


Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr 
        35                  40                  45              


Ile Cys Thr Tyr Ile Asn Val Gln Glu Arg Asp Pro Lys Ala His Arg 
    50                  55                  60                  


Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Asp Lys Ala Val 
65                  70                  75                  80  


Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu 
                85                  90                  95      


Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly 
            100                 105                 110         


Arg Ala Lys Tyr Trp Leu Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser 
        115                 120                 125             


Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu 
    130                 135                 140                 


Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val 
145                 150                 155                 160 


Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Val Tyr Arg 
                165                 170                 175     


Ser Thr Lys Arg Leu Lys Asp Ala Val Ala His Cys His Glu Ala Glu 
            180                 185                 190         


Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val 
        195                 200                 205             


Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp 
    210                 215                 220                 


Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala 
225                 230                 235                 240 


Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg 
                245                 250                 255     


Glu Leu Leu Gln Ser Phe Asp Ser Ala Leu Gln Ser Val Lys Ser Leu 
            260                 265                 270         


Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly His 
        275                 280                 285             


Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His Ser 
    290                 295                 300                 


Ser Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys Tyr 
305                 310                 315                 320 


Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys Gly 
                325                 330                 335     


Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu Ser 
            340                 345                 350         


Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp Phe 
        355                 360                 365             


Leu Lys Glu Ile Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser Ala 
    370                 375                 380                 


Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser Phe 
385                 390                 395                 400 


Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Arg Glu Pro Glu Leu 
                405                 410                 415     


Glu Asp Leu Thr Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn Gly 
            420                 425                 430         


Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu Pro 
        435                 440                 445             


Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His Leu 
    450                 455                 460                 


Pro His Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile Cys 
465                 470                 475                 480 


Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser His 
                485                 490                 495     


Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln Pro 
            500                 505                 510         


Leu Cys Leu Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg Gln 
        515                 520                 525             


Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala Val 
    530                 535                 540                 


Pro Gly Asn Val Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile Asn 
545                 550                 555                 560 


Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu Val 
                565                 570                 575     


His Trp Ala Glu Cys Leu Gln Lys Thr Gly Ser Gly Leu Asn Ser Phe 
            580                 585                 590         


Tyr Asp Gln Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys Lys 
        595                 600                 605             


Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro Glu 
    610                 615                 620                 


Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln Ala 
625                 630                 635                 640 


Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Ile Thr Phe Ala Ile 
                645                 650                 655     


Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Val Thr Ala Phe Glu 
            660                 665                 670         


Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe His 
        675                 680                 685             


Arg Lys Ala Glu Asp Ile Glu Asn Asp Ala Leu Ser Pro Glu Glu Gln 
    690                 695                 700                 


Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr Arg Asp Tyr Leu Ile Lys 
705                 710                 715                 720 


Ile Ile Asp Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu Pro 
                725                 730                 735     


Val Pro Leu Glu Ser Val Lys Glu Met Leu Asn Ser Val Met Gln Glu 
            740                 745                 750         


Leu Glu Asp Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser Leu 
        755                 760                 765             


Arg Asn Ala Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr Arg 
    770                 775                 780                 


Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Lys Thr Pro 
785                 790                 795                 800 


Pro Arg Trp Ala Glu Asp Gln Asn Ser Leu Leu Lys Met Ile Cys Gln 
                805                 810                 815     


Gln Val Glu Ala Ile Lys Lys Glu Met Gln Glu Leu Lys Leu Asn Ser 
            820                 825                 830         


Ser Asn Ser Ala Ser Pro His Arg Trp Pro Thr Glu Asn Tyr Gly Pro 
        835                 840                 845             


Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly Ala 
    850                 855                 860                 


Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln Ser 
865                 870                 875                 880 


Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val Thr 
                885                 890                 895     


Pro Thr Lys Gly Pro Val Tyr Gly Met Asn Arg Leu Pro Pro Gln Gln 
            900                 905                 910         


His Ile Tyr Ala Tyr Pro Gln Gln Met His Thr Pro Pro Val Gln Ser 
        915                 920                 925             


Ser Ser Ala Cys Met Phe Ser Gln Glu Met Tyr Gly Pro Pro Ala Leu 
    930                 935                 940                 


Arg Phe Glu Ser Pro Ala Thr Gly Ile Leu Ser Pro Arg Gly Asp Asp 
945                 950                 955                 960 


Tyr Phe Asn Tyr Asn Val Gln Gln Thr Ser Thr Asn Pro Pro Leu Pro 
                965                 970                 975     


Glu Pro Gly Tyr Phe Thr Lys Pro Pro Ile Ala Ala His Ala Ser Arg 
            980                 985                 990         


Ser Ala Glu Ser Lys Thr Ile Glu  Phe Gly Lys Thr Asn  Phe Val Gln 
        995                 1000                 1005             


Pro Met  Pro Gly Glu Gly Leu  Arg Pro Ser Leu Pro  Thr Gln Ala 
    1010                 1015                 1020             


His Thr  Thr Gln Pro Thr Pro  Phe Lys Phe Asn Ser  Asn Phe Lys 
    1025                 1030                 1035             


Ser Asn  Asp Gly Asp Phe Thr  Phe Ser Ser Pro Gln  Val Val Thr 
    1040                 1045                 1050             


Gln Pro  Pro Pro Ala Ala Tyr  Ser Asn Ser Glu Ser  Leu Leu Gly 
    1055                 1060                 1065             


Leu Leu  Thr Ser Asp Lys Pro  Leu Gln Gly Asp Gly  Tyr Ser Gly 
    1070                 1075                 1080             


Ala Lys  Pro Ile Pro Gly Gly  Gln Thr Ile Gly Pro  Arg Asn Thr 
    1085                 1090                 1095             


Phe Asn  Phe Gly Ser Lys Asn  Val Ser Gly Ile Ser  Phe Thr Glu 
    1100                 1105                 1110             


Asn Met  Gly Ser Ser Gln Gln  Lys Asn Ser Gly Phe  Arg Arg Ser 
    1115                 1120                 1125             


Asp Asp  Met Phe Thr Phe His  Gly Pro Gly Lys Ser  Val Phe Gly 
    1130                 1135                 1140             


Thr Pro  Thr Leu Glu Thr Ala  Asn Lys Asn His Glu  Thr Asp Gly 
    1145                 1150                 1155             


Gly Ser  Ala His Gly Asp Asp  Asp Asp Asp Gly Pro  His Phe Glu 
    1160                 1165                 1170             


Pro Val  Val Pro Leu Pro Asp  Lys Ile Glu Val Lys  Thr Gly Glu 
    1175                 1180                 1185             


Glu Asp  Glu Glu Glu Phe Phe  Cys Asn Arg Ala Lys  Leu Phe Arg 
    1190                 1195                 1200             


Phe Asp  Val Glu Ser Lys Glu  Trp Lys Glu Arg Gly  Ile Gly Asn 
    1205                 1210                 1215             


Val Lys  Ile Leu Arg His Lys  Thr Ser Gly Lys Ile  Arg Leu Leu 
    1220                 1225                 1230             


Met Arg  Arg Glu Gln Val Leu  Lys Ile Cys Ala Asn  His Tyr Ile 
    1235                 1240                 1245             


Ser Pro  Asp Met Lys Leu Thr  Pro Asn Ala Gly Ser  Asp Arg Ser 
    1250                 1255                 1260             


Phe Val  Trp His Ala Leu Asp  Tyr Ala Asp Glu Leu  Pro Lys Pro 
    1265                 1270                 1275             


Glu Gln  Leu Ala Ile Arg Phe  Lys Thr Pro Glu Glu  Ala Ala Leu 
    1280                 1285                 1290             


Phe Lys  Cys Lys Phe Glu Glu  Ala Gln Ser Ile Leu  Lys Ala Pro 
    1295                 1300                 1305             


Gly Thr  Asn Val Ala Met Ala  Ser Asn Gln Ala Val  Arg Ile Val 
    1310                 1315                 1320             


Lys Glu  Pro Thr Ser His Asp  Asn Lys Asp Ile Cys  Lys Ser Asp 
    1325                 1330                 1335             


Ala Gly  Asn Leu Asn Phe Glu  Phe Gln Val Ala Lys  Lys Glu Gly 
    1340                 1345                 1350             


Ser Trp  Trp His Cys Asn Ser  Cys Ser Leu Lys Asn  Ala Ser Thr 
    1355                 1360                 1365             


Ala Lys  Lys Cys Val Ser Cys  Gln Asn Leu Asn Pro  Ser Asn Lys 
    1370                 1375                 1380             


Glu Leu  Val Gly Pro Pro Leu  Ala Glu Thr Val Phe  Thr Pro Lys 
    1385                 1390                 1395             


Thr Ser  Pro Glu Asn Val Gln  Asp Arg Phe Ala Leu  Val Thr Pro 
    1400                 1405                 1410             


Lys Lys  Glu Gly His Trp Asp  Cys Ser Ile Cys Leu  Val Arg Asn 
    1415                 1420                 1425             


Glu Pro  Thr Val Ser Arg Cys  Ile Ala Cys Gln Asn  Thr Lys Ser 
    1430                 1435                 1440             


Ala Asn  Lys Ser Gly Ser Ser  Phe Val His Gln Ala  Ser Phe Lys 
    1445                 1450                 1455             


Phe Gly  Gln Gly Asp Leu Pro  Lys Pro Ile Asn Ser  Asp Phe Arg 
    1460                 1465                 1470             


Ser Val  Phe Ser Thr Lys Glu  Gly Gln Trp Asp Cys  Ser Ala Cys 
    1475                 1480                 1485             


Leu Val  Gln Asn Glu Gly Ser  Ser Thr Lys Cys Ala  Ala Cys Gln 
    1490                 1495                 1500             


Asn Pro  Arg Lys Gln Ser Leu  Pro Ala Thr Ser Ile  Pro Thr Pro 
    1505                 1510                 1515             


Ala Ser  Phe Lys Phe Gly Thr  Ser Glu Thr Ser Lys  Thr Leu Lys 
    1520                 1525                 1530             


Ser Gly  Phe Glu Asp Met Phe  Ala Lys Lys Glu Gly  Gln Trp Asp 
    1535                 1540                 1545             


Cys Ser  Ser Cys Leu Val Arg  Asn Glu Ala Asn Ala  Thr Arg Cys 
    1550                 1555                 1560             


Val Ala  Cys Gln Asn Pro Asp  Lys Pro Ser Pro Ser  Thr Ser Val 
    1565                 1570                 1575             


Pro Ala  Pro Ala Ser Phe Lys  Phe Gly Thr Ser Glu  Thr Ser Lys 
    1580                 1585                 1590             


Ala Pro  Lys Ser Gly Phe Glu  Gly Met Phe Thr Lys  Lys Glu Gly 
    1595                 1600                 1605             


Gln Trp  Asp Cys Ser Val Cys  Leu Val Arg Asn Glu  Ala Ser Ala 
    1610                 1615                 1620             


Thr Lys  Cys Ile Ala Cys Gln  Asn Pro Gly Lys Gln  Asn Gln Thr 
    1625                 1630                 1635             


Thr Ser  Ala Val Ser Thr Pro  Ala Ser Ser Glu Thr  Ser Lys Ala 
    1640                 1645                 1650             


Pro Lys  Ser Gly Phe Glu Gly  Met Phe Thr Lys Lys  Glu Gly Gln 
    1655                 1660                 1665             


Trp Asp  Cys Ser Val Cys Leu  Val Arg Asn Glu Ala  Ser Ala Thr 
    1670                 1675                 1680             


Lys Cys  Ile Ala Cys Gln Asn  Pro Gly Lys Gln Asn  Gln Thr Thr 
    1685                 1690                 1695             


Ser Ala  Val Ser Thr Pro Ala  Ser Ser Glu Thr Ser  Lys Ala Pro 
    1700                 1705                 1710             


Lys Ser  Gly Phe Glu Gly Met  Phe Thr Lys Lys Glu  Gly Gln Trp 
    1715                 1720                 1725             


Asp Cys  Ser Val Cys Leu Val  Arg Asn Glu Ala Ser  Ala Thr Lys 
    1730                 1735                 1740             


Cys Ile  Ala Cys Gln Cys Pro  Ser Lys Gln Asn Gln  Thr Thr Ala 
    1745                 1750                 1755             


Ile Ser  Thr Pro Ala Ser Ser  Glu Ile Ser Lys Ala  Pro Lys Ser 
    1760                 1765                 1770             


Gly Phe  Glu Gly Met Phe Ile  Arg Lys Gly Gln Trp  Asp Cys Ser 
    1775                 1780                 1785             


Val Cys  Cys Val Gln Asn Glu  Ser Ser Ser Leu Lys  Cys Val Ala 
    1790                 1795                 1800             


Cys Asp  Ala Ser Lys Pro Thr  His Lys Pro Ile Ala  Glu Ala Pro 
    1805                 1810                 1815             


Ser Ala  Phe Thr Leu Gly Ser  Glu Met Lys Leu His  Asp Ser Ser 
    1820                 1825                 1830             


Gly Ser  Gln Val Gly Thr Gly  Phe Lys Ser Asn Phe  Ser Glu Lys 
    1835                 1840                 1845             


Ala Ser  Lys Phe Gly Asn Thr  Glu Gln Gly Phe Lys  Phe Gly His 
    1850                 1855                 1860             


Val Asp  Gln Glu Asn Ser Pro  Ser Phe Met Phe Gln  Gly Ser Ser 
    1865                 1870                 1875             


Asn Thr  Glu Phe Lys Ser Thr  Lys Glu Gly Phe Ser  Ile Pro Val 
    1880                 1885                 1890             


Ser Ala  Asp Gly Phe Lys Phe  Gly Ile Ser Glu Pro  Gly Asn Gln 
    1895                 1900                 1905             


Glu Lys  Lys Ser Glu Lys Pro  Leu Glu Asn Gly Thr  Gly Phe Gln 
    1910                 1915                 1920             


Ala Gln  Asp Ile Ser Gly Gln  Lys Asn Gly Arg Gly  Val Ile Phe 
    1925                 1930                 1935             


Gly Gln  Thr Ser Ser Thr Phe  Thr Phe Ala Asp Leu  Ala Lys Ser 
    1940                 1945                 1950             


Thr Ser  Gly Glu Gly Phe Gln  Phe Gly Lys Lys Asp  Pro Asn Phe 
    1955                 1960                 1965             


Lys Gly  Phe Ser Gly Ala Gly  Glu Lys Leu Phe Ser  Ser Gln Tyr 
    1970                 1975                 1980             


Gly Lys  Met Ala Asn Lys Ala  Asn Thr Ser Gly Asp  Phe Glu Lys 
    1985                 1990                 1995             


Asp Asp  Asp Ala Tyr Lys Thr  Glu Asp Ser Asp Asp  Ile His Phe 
    2000                 2005                 2010             


Glu Pro  Val Val Gln Met Pro  Glu Lys Val Glu Leu  Val Thr Gly 
    2015                 2020                 2025             


Glu Glu  Asp Glu Lys Val Leu  Tyr Ser Gln Arg Val  Lys Leu Phe 
    2030                 2035                 2040             


Arg Phe  Asp Ala Glu Val Ser  Gln Trp Lys Glu Arg  Gly Leu Gly 
    2045                 2050                 2055             


Asn Leu  Lys Ile Leu Lys Asn  Glu Val Asn Gly Lys  Leu Arg Met 
    2060                 2065                 2070             


Leu Met  Arg Arg Glu Gln Val  Leu Lys Val Cys Ala  Asn His Trp 
    2075                 2080                 2085             


Ile Thr  Thr Thr Met Asn Leu  Lys Pro Leu Ser Gly  Ser Asp Arg 
    2090                 2095                 2100             


Ala Trp  Met Trp Leu Ala Ser  Asp Phe Ser Asp Gly  Asp Ala Lys 
    2105                 2110                 2115             


Leu Glu  Gln Leu Ala Ala Lys  Phe Lys Thr Pro Glu  Leu Ala Glu 
    2120                 2125                 2130             


Glu Phe  Lys Gln Lys Phe Glu  Glu Cys Gln Arg Leu  Leu Leu Asp 
    2135                 2140                 2145             


Ile Pro  Leu Gln Thr Pro His  Lys Leu Val Asp Thr  Gly Arg Ala 
    2150                 2155                 2160             


Ala Lys  Leu Ile Gln Arg Ala  Glu Glu Met Lys Ser  Gly Leu Lys 
    2165                 2170                 2175             


Asp Phe  Lys Thr Phe Leu Thr  Asn Asp Gln Thr Lys  Val Thr Glu 
    2180                 2185                 2190             


Glu Glu  Asn Lys Gly Ser Gly  Thr Gly Ala Ala Gly  Ala Ser Asp 
    2195                 2200                 2205             


Thr Thr  Ile Lys Pro Asn Pro  Glu Asn Thr Gly Pro  Thr Leu Glu 
    2210                 2215                 2220             


Trp Asp  Asn Tyr Asp Leu Arg  Glu Asp Ala Leu Asp  Asp Ser Val 
    2225                 2230                 2235             


Ser Ser  Ser Ser Val His Ala  Ser Pro Leu Ala Ser  Ser Pro Val 
    2240                 2245                 2250             


Arg Lys  Asn Leu Phe Arg Phe  Gly Glu Ser Thr Thr  Gly Phe Asn 
    2255                 2260                 2265             


Phe Ser  Phe Lys Ser Ala Leu  Ser Pro Ser Lys Ser  Pro Ala Lys 
    2270                 2275                 2280             


Leu Asn  Gln Ser Gly Thr Ser  Val Gly Thr Asp Glu  Glu Ser Asp 
    2285                 2290                 2295             


Val Thr  Gln Glu Glu Glu Arg  Asp Gly Gln Tyr Phe  Glu Pro Val 
    2300                 2305                 2310             


Val Pro  Leu Pro Asp Leu Val  Glu Val Ser Ser Gly  Glu Glu Asn 
    2315                 2320                 2325             


Glu Gln  Val Val Phe Ser His  Arg Ala Lys Leu Tyr  Arg Tyr Asp 
    2330                 2335                 2340             


Lys Asp  Val Gly Gln Trp Lys  Glu Arg Gly Ile Gly  Asp Ile Lys 
    2345                 2350                 2355             


Ile Leu  Gln Asn Tyr Asp Asn  Lys Gln Val Arg Ile  Val Met Arg 
    2360                 2365                 2370             


Arg Asp  Gln Val Leu Lys Leu  Cys Ala Asn His Arg  Ile Thr Pro 
    2375                 2380                 2385             


Asp Met  Thr Leu Gln Asn Met  Lys Gly Thr Glu Arg  Val Trp Leu 
    2390                 2395                 2400             


Trp Thr  Ala Cys Asp Phe Ala  Asp Gly Glu Arg Lys  Val Glu His 
    2405                 2410                 2415             


Leu Ala  Val Arg Phe Lys Leu  Gln Asp Val Ala Asp  Ser Phe Lys 
    2420                 2425                 2430             


Lys Ile  Phe Asp Glu Ala Lys  Thr Ala Gln Glu Lys  Asp Ser Leu 
    2435                 2440                 2445             


Ile Thr  Pro His Val Ser Arg  Ser Ser Thr Pro Arg  Glu Ser Pro 
    2450                 2455                 2460             


Cys Gly  Lys Ile Ala Val Ala  Val Leu Glu Glu Thr  Thr Arg Glu 
    2465                 2470                 2475             


Arg Thr  Asp Val Ile Gln Gly  Asp Asp Val Ala Asp  Ala Thr Ser 
    2480                 2485                 2490             


Glu Val  Glu Val Ser Ser Thr  Ser Glu Thr Thr Pro  Lys Ala Val 
    2495                 2500                 2505             


Val Ser  Pro Pro Lys Phe Val  Phe Gly Ser Glu Ser  Val Lys Ser 
    2510                 2515                 2520             


Ile Phe  Ser Ser Glu Lys Ser  Lys Pro Phe Ala Phe  Gly Asn Ser 
    2525                 2530                 2535             


Ser Ala  Thr Gly Ser Leu Phe  Gly Phe Ser Phe Asn  Ala Pro Leu 
    2540                 2545                 2550             


Lys Ser  Asn Asn Ser Glu Thr  Ser Ser Val Ala Gln  Ser Gly Ser 
    2555                 2560                 2565             


Glu Ser  Lys Val Glu Pro Lys  Lys Cys Glu Leu Ser  Lys Asn Ser 
    2570                 2575                 2580             


Asp Ile  Glu Gln Ser Ser Asp  Ser Lys Val Lys Asn  Leu Phe Ala 
    2585                 2590                 2595             


Ser Phe  Pro Thr Glu Glu Ser  Ser Ile Asn Tyr Thr  Phe Lys Thr 
    2600                 2605                 2610             


Pro Glu  Lys Ala Lys Glu Lys  Lys Lys Pro Glu Asp  Ser Pro Ser 
    2615                 2620                 2625             


Asp Asp  Asp Val Leu Ile Val  Tyr Glu Leu Thr Pro  Thr Ala Glu 
    2630                 2635                 2640             


Gln Lys  Ala Leu Ala Thr Lys  Leu Lys Leu Pro Pro  Thr Phe Phe 
    2645                 2650                 2655             


Cys Tyr  Lys Asn Arg Pro Asp  Tyr Val Ser Glu Glu  Glu Glu Asp 
    2660                 2665                 2670             


Asp Glu  Asp Phe Glu Thr Ala  Val Lys Lys Leu Asn  Gly Lys Leu 
    2675                 2680                 2685             


Tyr Leu  Asp Gly Ser Glu Lys  Cys Arg Pro Leu Glu  Glu Asn Thr 
    2690                 2695                 2700             


Ala Asp  Asn Glu Lys Glu Cys  Ile Ile Val Trp Glu  Lys Lys Pro 
    2705                 2710                 2715             


Thr Val  Glu Glu Lys Ala Lys  Ala Asp Thr Leu Lys  Leu Pro Pro 
    2720                 2725                 2730             


Thr Phe  Phe Cys Gly Val Cys  Ser Asp Thr Asp Glu  Asp Asn Gly 
    2735                 2740                 2745             


Asn Gly  Glu Asp Phe Gln Ser  Glu Leu Gln Lys Val  Gln Glu Ala 
    2750                 2755                 2760             


Gln Lys  Ser Gln Thr Glu Glu  Ile Thr Ser Thr Thr  Asp Ser Val 
    2765                 2770                 2775             


Tyr Thr  Gly Gly Thr Glu Val  Met Val Pro Ser Phe  Cys Lys Ser 
    2780                 2785                 2790             


Glu Glu  Pro Asp Ser Ile Thr  Lys Ser Ile Ser Ser  Pro Ser Val 
    2795                 2800                 2805             


Ser Ser  Glu Thr Met Asp Lys  Pro Val Asp Leu Ser  Thr Arg Lys 
    2810                 2815                 2820             


Glu Ile  Asp Thr Asp Ser Thr  Ser Gln Gly Glu Ser  Lys Ile Val 
    2825                 2830                 2835             


Ser Phe  Gly Phe Gly Ser Ser  Thr Gly Leu Ser Phe  Ala Asp Leu 
    2840                 2845                 2850             


Ala Ser  Ser Asn Ser Gly Asp  Phe Ala Phe Gly Ser  Lys Asp Lys 
    2855                 2860                 2865             


Asn Phe  Gln Trp Ala Asn Thr  Gly Ala Ala Val Phe  Gly Thr Gln 
    2870                 2875                 2880             


Ser Val  Gly Thr Gln Ser Ala  Gly Lys Val Gly Glu  Asp Glu Asp 
    2885                 2890                 2895             


Gly Ser  Asp Glu Glu Val Val  His Asn Glu Asp Ile  His Phe Glu 
    2900                 2905                 2910             


Pro Ile  Val Ser Leu Pro Glu  Val Glu Val Lys Ser  Gly Glu Glu 
    2915                 2920                 2925             


Asp Glu  Glu Ile Leu Phe Lys  Glu Arg Ala Lys Leu  Tyr Arg Trp 
    2930                 2935                 2940             


Asp Arg  Asp Val Ser Gln Trp  Lys Glu Arg Gly Val  Gly Asp Ile 
    2945                 2950                 2955             


Lys Ile  Leu Trp His Thr Met  Lys Asn Tyr Tyr Arg  Ile Leu Met 
    2960                 2965                 2970             


Arg Arg  Asp Gln Val Phe Lys  Val Cys Ala Asn His  Val Ile Thr 
    2975                 2980                 2985             


Lys Thr  Met Glu Leu Lys Pro  Leu Asn Val Ser Asn  Asn Ala Leu 
    2990                 2995                 3000             


Val Trp  Thr Ala Ser Asp Tyr  Ala Asp Gly Glu Ala  Lys Val Glu 
    3005                 3010                 3015             


Gln Leu  Ala Val Arg Phe Lys  Thr Lys Glu Val Ala  Asp Cys Phe 
    3020                 3025                 3030             


Lys Lys  Thr Phe Glu Glu Cys  Gln Gln Asn Leu Met  Lys Leu Gln 
    3035                 3040                 3045             


Lys Gly  His Val Ser Leu Ala  Ala Glu Leu Ser Lys  Glu Thr Asn 
    3050                 3055                 3060             


Pro Val  Val Phe Phe Asp Val  Cys Ala Asp Gly Glu  Pro Leu Gly 
    3065                 3070                 3075             


Arg Ile  Thr Met Glu Leu Phe  Ser Asn Ile Val Pro  Arg Thr Ala 
    3080                 3085                 3090             


Glu Asn  Phe Arg Ala Leu Cys  Thr Gly Glu Lys Gly  Phe Gly Phe 
    3095                 3100                 3105             


Lys Asn  Ser Ile Phe His Arg  Val Ile Pro Asp Phe  Val Cys Gln 
    3110                 3115                 3120             


Gly Gly  Asp Ile Thr Lys His  Asp Gly Thr Gly Gly  Gln Ser Ile 
    3125                 3130                 3135             


Tyr Gly  Asp Lys Phe Glu Asp  Glu Asn Phe Asp Val  Lys His Thr 
    3140                 3145                 3150             


Gly Pro  Gly Leu Leu Ser Met  Ala Asn Gln Gly Gln  Asn Thr Asn 
    3155                 3160                 3165             


Asn Ser  Gln Phe Val Ile Thr  Leu Lys Lys Ala Glu  His Leu Asp 
    3170                 3175                 3180             


Phe Lys  His Val Val Phe Gly  Phe Val Lys Asp Gly  Met Asp Thr 
    3185                 3190                 3195             


Val Lys  Lys Ile Glu Ser Phe  Gly Ser Pro Lys Gly  Ser Val Cys 
    3200                 3205                 3210             


Arg Arg  Ile Thr Ile Thr Glu  Cys Gly Gln Ile 
    3215                 3220                 


<210>  8213
<211>  1417
<212>  DNA
<213>  Homosapiens

<400>  8213
aaaacagata catatgtact tacattaatg tgcaagagag ggatcccaaa gctcacagat     60

ttctgggtct tctttatgaa ttggaagaaa acacagacaa agccgttgaa tgttacaggc    120

gttcagtgga attaaaccca acacaaaaag atcttgtgtt gaagattgca gaattgcttt    180

gtaaaaatga tgttactgat ggaagagcaa aatactggct tgaaagagca gccaaacttt    240

tcccaggaag tcctgcaatt tataaactaa aggaacagct tctagattgt gaaggtgaag    300

atggatggaa taaacttttt gacttgattc agtcagaact ttatgtaaga cctgatgacg    360

tccatgtgaa catccggcta gtggaggtgt atcgctcaac taaaagattg aaggatgctg    420

tggcccactg ccatgaggca gagaggaaca tagctttgcg ttcaagttta gaatggaatt    480

cgtgtgttgt acagaccaat aactatcaca gaatgtggac agatataaaa tcattgttgt    540

tcatagaaaa tttcatctgt ataagcagtt ggattgaagc ttagctatta caatttgata    600

gttatgttca gcttttgaaa atggacgttt ccgatttaca aatgtaaaat tgcagcttat    660

agctgttgtc actttttaat gtgttataat tgaccttgca tggtgtgaaa taaaagttta    720

aacactggtg tatttcaggt gtacttgtgt ttatgtactc ctgacgtatt aaaatggaat    780

aatactaatc ttgttaaaag caatagacct caaactattg aaggaatatg atatatgcaa    840

tttaatttta attcctttta agatatttgg acttcctgca tggatatact taccatttga    900

ataaagggac cacaacttgg ataatttaat tttaggtttg aaatatattt ggtaatctta    960

actattggtg tactcattta tgcatagaga ctcgtttatg aatgggtaga gccacagaac   1020

gtatagagtt aaccaaagtg ctcttctcta gaatctttac acctcctgtg tggttacaag   1080

ttaactttgt aagtagcgta ccttccttcc ttaaaatatc tagcttcctg tgccctttca   1140

tagatattcg attaattttt acattttaaa caagttgact atttccttta ggggttttgt   1200

ttcaaacttt tctgtcatct gtctctacta cctcagaaac tgcagcttgg ttctgatgat   1260

agaaattgaa tttttccttg tagttattgt gataaagtat gaatattttt agaaagtcta   1320

taccatgttc tttcgttaaa gatttgcttt atacaagatt gttgcagtac ctttttctgg   1380

taaattttgt agcagaaata aaatgacaat tcctaag                            1417


<210>  8214
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  8214

Met Cys Lys Arg Gly Ile Pro Lys Leu Thr Asp Phe Trp Val Phe Phe 
1               5                   10                  15      


Met Asn Trp Lys Lys Thr Gln Thr Lys Pro Leu Asn Val Thr Gly Val 
            20                  25                  30          


Gln Trp Asn 
        35  


<210>  8215
<211>  2440
<212>  DNA
<213>  Homosapiens

<400>  8215
aaaacagata catatgtact tacattaatg tgcaagagag ggatcccaaa gctcacagat     60

ttctgggtct tctttatgaa ttggaagaaa acacagacaa agccgttgaa tgttacaggc    120

gttcagtgga attaaaccca acacaaaaag atcttgtgtt gaagattgca gaattgcttt    180

gtaaaaatga tgttactgat ggaagagcaa aatactggct tgaaagagca gccaaacttt    240

tcccaggaag tcctgcaatt tataaactaa aggaacagct tctagattgt gaaggtgaag    300

atggatggaa taaacttttt gacttgattc agtcagaact ttatgtaaga cctgatgacg    360

tccatgtgaa catccggcta gtggaggtgt atcgctcaac taaaagattg aaggatgctg    420

tggcccactg ccatgaggca gagaggaaca tagctttgcg ttcaagttta gaatggaatt    480

cgtgtgttgt acagaccaat aactatcaca gaatgtggac agatataaaa tcattgttgt    540

tcatagaaaa tttcatctgt ataagcagtt ggattgaagc ttagctatta caatttgata    600

gttatgttca gcttttgaaa atggacgttt ccgatttaca aatgtaaaat tgcagcttat    660

agctgttgtc actttttaat gtgttataat tgaccttgca tggtgtgaaa taaaagttta    720

aacactggtg tatttcaggt gtacttgtgt ttatgtactc ctgacgtatt aaaatggaat    780

aatactaatc ttgttaaaag caatagacct caaactattg aaggaatatg atatatgcaa    840

tttaatttta attcctttta agatatttgg acttcctgca tggatatact taccatttga    900

ataaagggac cacaacttgg ataatttaat tttaggtttg aaatatattt ggtaatctta    960

actattggtg tactcattta tgcatagaga ctcgtttatg aatgggtaga gccacagaac   1020

gtatagagtt aaccaaagtg ctcttctcta gaatctttac acctcctgtg tggttacaag   1080

ttaactttgt aagtagcgta ccttccttcc ttaaaatatc tagcttcctg tgccctttca   1140

tagatattcg attaattttt acattttaaa caagttgact atttccttta ggggttttgt   1200

ttcaaacttt tctgtcatct gtctctacta cctcagaaac tgcagcttgg ttctgatgat   1260

agaaattgaa tttttccttg tagttattgt gataaagtat gaatattttt agaaagtcta   1320

taccatgttc tttcgttaaa gatttgcttt atacaagatt gttgcagtac ctttttctgg   1380

taaattttgt agcagaaata aaatgacaat tcctaagagc cactgacatc caaaaaattc   1440

attacttacg cttcgggttc attctaaagt aaggaagaca atttaaaggc agtaaattca   1500

aactgctgca taatttccag agctcctagt ttctcaagtt tgatacacac caaaaacgta   1560

tttggaaatg gcttgtatca aatgttaggc aaattgctaa agaaaagagg atgttcttat   1620

tggcctactc aatatggaac tacaaagaat ccaggtagaa cacaaaattt tgtatattgc   1680

aattatgaat attgactgtc ttccacccat ctgtgttctt tcgggtgaaa ttacctcatt   1740

ttatttagtg aggaaagaca ggtttattcc ctgttacatg gggatttgga aattgggtat   1800

cctaaagcaa gtaactgttc aaccaccagt caaaagaggg gagggatgtt gtgcgagtaa   1860

tgagtgatgg tataccatca ccattccact cggccacaaa gccagatact tgaaataaac   1920

ctactccaaa tgtatcagtt cagtcttgaa ccatggatta catatgttta cactaaatat   1980

ttcaaattgg cttatttgga aatctatgta atataaactg atgtaaagtg tgttgtaact   2040

tttcagctga gacagttgat gccttcgtca tgattttaga ataaattctt aagttaatgc   2100

aagtgctttt taagagactt tttacagatt tgtatgcttt cctaaagcac taaagttaca   2160

aattaaaaag ctttaaaaac tttgaccaaa aatttgacaa aatgacatgt aaactgactt   2220

ttcccgtatt agtattccaa agatgcttaa aagtggcttg tggcatttat gagaaagtct   2280

ttgtgtcaca tttcaggaaa ggactttgat ttctctttgt tatttaatca ctgatgtggt   2340

ctaaacccac gataatatgt atctttcctt ttaaactgga ttttatgttg tctcattaaa   2400

atctgcttaa agatagaata aaattcatta tttgtacatc                         2440


<210>  8216
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  8216

Met Cys Lys Arg Gly Ile Pro Lys Leu Thr Asp Phe Trp Val Phe Phe 
1               5                   10                  15      


Met Asn Trp Lys Lys Thr Gln Thr Lys Pro Leu Asn Val Thr Gly Val 
            20                  25                  30          


Gln Trp Asn 
        35  


<210>  8217
<211>  2209
<212>  DNA
<213>  Homosapiens

<400>  8217
ggccgcgtag cgccgcgggt ttgatgaacg cggttcccgg ggagactggt acggttgctg     60

tgtgctatgg agccgagggt cgtcaagcca ccggggcagg atttagtagt ggagagtctc    120

aaaagccgct acggactcgg gggcagctgc cccgacgagt atgatttttc aaatttttat    180

cagtctaagt ataagagaag aactctaacc tccccaggtg atttggatat ctactctgga    240

gataaagttg gttcatcgtt aaaatattct gatgaaagca agcattgtag aacaccattg    300

ggcagcttat tcaagcacgt aaatgtgaat tgcctagatg atgaactgga ttctttccat    360

gatttgaaga aacaggaaac agaagaagag ttaattgaaa atgattatag agttagtacc    420

tcgaaaataa ccaagcagtc ttttaaagaa atagaaaaag ttgccttgcc aactaatacg    480

acctcatcga gacctcggac tgagtgttgt agtgatgcag gtgactctcc tttgaaacct    540

gtcagctgtc caaaatctaa agcatcagac aagcggagtt tacttccaca tcagatcagt    600

cagatatatg acgaattatt tcagatacat ctgaaattgc agtgtgaaac tgcagcacaa    660

cagaaatttg ctgaagaact tcaaaagcga gaacgttttt tacttgaaag agaacaactg    720

cttttcagac atgaaaatgc cttgagtaaa attaaaggtg ttgaagaaga ggttcttaca    780

agatttcaaa ttataaaaga gcagcatgat gcagaagttg aacacttaac cgaagttctt    840

aaggaaaaga ataaagaaac caagagactg aggtcctctt ttgatgcatt gaaagaattg    900

aatgatacct taaaaaaaca gttaaatgaa gcaagtgaag aaaacaggaa gatagacatt    960

caggctaaaa gagttcaagc tcgtttagat aatttacaga ggaagtacga gtttatgaca   1020

atacagagat tgaaaggaag ttcccatgct gttcatgaaa tgaaaagttt aaaacaagaa   1080

aaagcaccag tttcaaaaac ttacaaggta ccacttaatg ggcaagttta tgaactttta   1140

actgtcttca tggactggat ttcggatcat catcttagca aagtgaaaca tgaagaatct   1200

ggaatggatg gtaaaaaacc acaactcaaa tttgcttccc agagaaatga tattcaggag   1260

aagtgtgtaa agcttttgcc tctaatgaca gagcagctac agtggatgcc atttgtgaat   1320

atcaaacttc acgagccttt tgtaaaattt atatattggt ccctaaggca gctagatgct   1380

ggagcacagc actcgactat gacatcaaca ttgaggagat tgggtgaaga catttttaaa   1440

ggagtggtaa ctaaaggaat tcaggataat tctccacagc attctgtgga gaataaacca   1500

aagacagctg ctttctttaa gagctccaat ttgccattga gatttttatc aaccttaatt   1560

gttctcaaaa cagtcactca agctgattac ctggctcagg catttgattc tctttgtttg   1620

gacttgaaga cagaagaagg aaaaaccttg tttttggagt atcaggctgt tccagtaata   1680

ttaagtcatc taagaatatc cagtaaagga ctcctgtcta atgttattga tagtttgctc   1740

cagatgacgg tggaatctaa atccttgcag cctttcctgg aagcctgtag caactcttta   1800

ttttttcgta cttgctctgt gctgcttcga gcccctaagc ttgatcttca aatactagaa   1860

aaactcagta ttattttaca gaaactttcc aaaatcaaga gtaataagaa gctctttgaa   1920

ctttttacga ttcatctgat gcttcaagaa atacaaagga caacaaaccc agagcatgca   1980

tttctctgta ttaatctaaa ttcaactctg ttcaatctgg gtttaacaaa atgtaactcc   2040

ctggtctcca gtgcaagccc ttagactggc taatttttta atatagtata tgtggtgctt   2100

atttataaac atgtagaaat taccaaagta actacaattc taccaagtaa agttatcagt   2160

agcatcattt atcatgaaaa ataaataatt tttttgaact gtaaaaatg               2209


<210>  8218
<211>  665
<212>  PRT
<213>  Homosapiens

<400>  8218

Met Glu Pro Arg Val Val Lys Pro Pro Gly Gln Asp Leu Val Val Glu 
1               5                   10                  15      


Ser Leu Lys Ser Arg Tyr Gly Leu Gly Gly Ser Cys Pro Asp Glu Tyr 
            20                  25                  30          


Asp Phe Ser Asn Phe Tyr Gln Ser Lys Tyr Lys Arg Arg Thr Leu Thr 
        35                  40                  45              


Ser Pro Gly Asp Leu Asp Ile Tyr Ser Gly Asp Lys Val Gly Ser Ser 
    50                  55                  60                  


Leu Lys Tyr Ser Asp Glu Ser Lys His Cys Arg Thr Pro Leu Gly Ser 
65                  70                  75                  80  


Leu Phe Lys His Val Asn Val Asn Cys Leu Asp Asp Glu Leu Asp Ser 
                85                  90                  95      


Phe His Asp Leu Lys Lys Gln Glu Thr Glu Glu Glu Leu Ile Glu Asn 
            100                 105                 110         


Asp Tyr Arg Val Ser Thr Ser Lys Ile Thr Lys Gln Ser Phe Lys Glu 
        115                 120                 125             


Ile Glu Lys Val Ala Leu Pro Thr Asn Thr Thr Ser Ser Arg Pro Arg 
    130                 135                 140                 


Thr Glu Cys Cys Ser Asp Ala Gly Asp Ser Pro Leu Lys Pro Val Ser 
145                 150                 155                 160 


Cys Pro Lys Ser Lys Ala Ser Asp Lys Arg Ser Leu Leu Pro His Gln 
                165                 170                 175     


Ile Ser Gln Ile Tyr Asp Glu Leu Phe Gln Ile His Leu Lys Leu Gln 
            180                 185                 190         


Cys Glu Thr Ala Ala Gln Gln Lys Phe Ala Glu Glu Leu Gln Lys Arg 
        195                 200                 205             


Glu Arg Phe Leu Leu Glu Arg Glu Gln Leu Leu Phe Arg His Glu Asn 
    210                 215                 220                 


Ala Leu Ser Lys Ile Lys Gly Val Glu Glu Glu Val Leu Thr Arg Phe 
225                 230                 235                 240 


Gln Ile Ile Lys Glu Gln His Asp Ala Glu Val Glu His Leu Thr Glu 
                245                 250                 255     


Val Leu Lys Glu Lys Asn Lys Glu Thr Lys Arg Leu Arg Ser Ser Phe 
            260                 265                 270         


Asp Ala Leu Lys Glu Leu Asn Asp Thr Leu Lys Lys Gln Leu Asn Glu 
        275                 280                 285             


Ala Ser Glu Glu Asn Arg Lys Ile Asp Ile Gln Ala Lys Arg Val Gln 
    290                 295                 300                 


Ala Arg Leu Asp Asn Leu Gln Arg Lys Tyr Glu Phe Met Thr Ile Gln 
305                 310                 315                 320 


Arg Leu Lys Gly Ser Ser His Ala Val His Glu Met Lys Ser Leu Lys 
                325                 330                 335     


Gln Glu Lys Ala Pro Val Ser Lys Thr Tyr Lys Val Pro Leu Asn Gly 
            340                 345                 350         


Gln Val Tyr Glu Leu Leu Thr Val Phe Met Asp Trp Ile Ser Asp His 
        355                 360                 365             


His Leu Ser Lys Val Lys His Glu Glu Ser Gly Met Asp Gly Lys Lys 
    370                 375                 380                 


Pro Gln Leu Lys Phe Ala Ser Gln Arg Asn Asp Ile Gln Glu Lys Cys 
385                 390                 395                 400 


Val Lys Leu Leu Pro Leu Met Thr Glu Gln Leu Gln Trp Met Pro Phe 
                405                 410                 415     


Val Asn Ile Lys Leu His Glu Pro Phe Val Lys Phe Ile Tyr Trp Ser 
            420                 425                 430         


Leu Arg Gln Leu Asp Ala Gly Ala Gln His Ser Thr Met Thr Ser Thr 
        435                 440                 445             


Leu Arg Arg Leu Gly Glu Asp Ile Phe Lys Gly Val Val Thr Lys Gly 
    450                 455                 460                 


Ile Gln Asp Asn Ser Pro Gln His Ser Val Glu Asn Lys Pro Lys Thr 
465                 470                 475                 480 


Ala Ala Phe Phe Lys Ser Ser Asn Leu Pro Leu Arg Phe Leu Ser Thr 
                485                 490                 495     


Leu Ile Val Leu Lys Thr Val Thr Gln Ala Asp Tyr Leu Ala Gln Ala 
            500                 505                 510         


Phe Asp Ser Leu Cys Leu Asp Leu Lys Thr Glu Glu Gly Lys Thr Leu 
        515                 520                 525             


Phe Leu Glu Tyr Gln Ala Val Pro Val Ile Leu Ser His Leu Arg Ile 
    530                 535                 540                 


Ser Ser Lys Gly Leu Leu Ser Asn Val Ile Asp Ser Leu Leu Gln Met 
545                 550                 555                 560 


Thr Val Glu Ser Lys Ser Leu Gln Pro Phe Leu Glu Ala Cys Ser Asn 
                565                 570                 575     


Ser Leu Phe Phe Arg Thr Cys Ser Val Leu Leu Arg Ala Pro Lys Leu 
            580                 585                 590         


Asp Leu Gln Ile Leu Glu Lys Leu Ser Ile Ile Leu Gln Lys Leu Ser 
        595                 600                 605             


Lys Ile Lys Ser Asn Lys Lys Leu Phe Glu Leu Phe Thr Ile His Leu 
    610                 615                 620                 


Met Leu Gln Glu Ile Gln Arg Thr Thr Asn Pro Glu His Ala Phe Leu 
625                 630                 635                 640 


Cys Ile Asn Leu Asn Ser Thr Leu Phe Asn Leu Gly Leu Thr Lys Cys 
                645                 650                 655     


Asn Ser Leu Val Ser Ser Ala Ser Pro 
            660                 665 


<210>  8219
<211>  2400
<212>  DNA
<213>  Homosapiens

<400>  8219
ggccgcgtag cgccgcgggt ttgatgaacg cggttcccgg ggagactggt acggttgctg     60

tgtgctatgg agccgagggt cgtcaagcca ccggggcagg atttagtagt ggagagtctc    120

aaaagccgct acggactcgg gggcagctgc cccgacgagt atgatttttc aaatttttat    180

cagtctaagt ataagagaag aactctaacc tccccaggtg atttggatat ctactctgga    240

gataaagttg gttcatcgtt aaaatattct gatgaaagca agcattgtag aacaccattg    300

ggcagcttat tcaagcacgt aaatgtgaat tgcctagatg atgaactgga ttctttccat    360

gatttgaaga aacaggaaac agaagaagag ttaattgaaa atgattatag agttagtacc    420

tcgaaaataa ccaagcagtc ttttaaagaa atagaaaaag ttgccttgcc aactaatacg    480

acctcatcga gacctcggac tgagtgttgt agtgatgcag gtgactctcc tttgaaacct    540

gtcagctgtc caaaatctaa agcatcagac aagcggagtt tacttccaca tcagatcagt    600

cagatatatg acgaattatt tcagatacat ctgaaattgc agtgtgaaac tgcagcacaa    660

cagaaatttg ctgaagaact tcaaaagcga gaacgttttt tacttgaaag agaacaactg    720

cttttcagac atgaaaatgc cttgagtaaa attaaaggtg ttgaagaaga ggttcttaca    780

agatttcaaa ttataaaaga gcagcatgat gcagaagttg aacacttaac cgaagttctt    840

aaggaaaaga ataaagaaac caagagactg aggtcctctt ttgatgcatt gaaagaattg    900

aatgatacct taaaaaaaca gttaaatgaa gcaagtgaag aaaacaggaa gatagacatt    960

caggctaaaa gagttcaagc tcgtttagat aatttacaga ggaagtacga gtttatgaca   1020

atacagagat tgaaaggaag ttcccatgct gttcatgaaa tgaaaagttt aaaacaagaa   1080

aaagcaccag tttcaaaaac ttacaaggta ccacttaatg ggcaagttta tgaactttta   1140

actgtcttca tggactggat ttcggatcat catcttagca aagtgaaaca tgaagaatct   1200

ggaatggatg gtaaaaaacc acaactcaaa tttgcttccc agagaaatga tattcaggag   1260

aagtgtgtaa agcttttgcc tctaatgaca gagcagctac agtggatgcc atttgtgaat   1320

atcaaacttc acgagccttt tgtaaaattt atatattggt ccctaaggca gctagatgct   1380

ggagcacagc actcgactat gacatcaaca ttgaggagat tgggtgaaga catttttaaa   1440

ggagtggtaa ctaaaggaat tcaggataat tctccacagc attctgtgga gaataaacca   1500

aagacagctg ctttctttaa gagctccaat ttgccattga gatttttatc aaccttaatt   1560

gttctcaaaa cagtcactca agctgattac ctggctcagg catttgattc tctttgtttg   1620

gacttgaaga cagaagaagg aaaaaccttg tttttggagt atcaggctgt tccagtaata   1680

ttaagtcatc taagaatatc cagtaaagga ctcctgtcta atgttattga tagtttgctc   1740

cagatgacgg tggaatctaa atccttgcag cctttcctgg aagcctgtag caactcttta   1800

ttttttcgta cttgctctgt gctgcttcga gcccctaagc ttgatcttca aatactagaa   1860

aaactcagta ttattttaca gaaactttcc aaaatcaaga gtaataagaa gctctttgaa   1920

ctttttacga ttcatctgat gcttcaagaa atacaaagga caacaaaccc agagcatgca   1980

tttctctgta ttaatctaaa ttcaactctg ttcaatctgg gtttaacaaa atgtaactcc   2040

ctggtctcca gtgcaagccc ttagactggc taatttttta atatagtata tgtggtgctt   2100

atttataaac atgtagaaat taccaaagta actacaattc taccaagtaa agttatcagt   2160

agcatcattt atcatgaaaa ataaataatt tttttgaact gtaaaaatga aatctgtaga   2220

aggtattgga acttttggaa tgtttcagtt caggtaaggt aatactaata tacaagatgg   2280

cgtttctaga atgtatgaca ctgaagtgac tttttgtaaa aatatattag gaaaattatt   2340

tcttaaaatt atgtgattat ttggaataaa attggtgctt atgtgagaac agggttaaat   2400


<210>  8220
<211>  665
<212>  PRT
<213>  Homosapiens

<400>  8220

Met Glu Pro Arg Val Val Lys Pro Pro Gly Gln Asp Leu Val Val Glu 
1               5                   10                  15      


Ser Leu Lys Ser Arg Tyr Gly Leu Gly Gly Ser Cys Pro Asp Glu Tyr 
            20                  25                  30          


Asp Phe Ser Asn Phe Tyr Gln Ser Lys Tyr Lys Arg Arg Thr Leu Thr 
        35                  40                  45              


Ser Pro Gly Asp Leu Asp Ile Tyr Ser Gly Asp Lys Val Gly Ser Ser 
    50                  55                  60                  


Leu Lys Tyr Ser Asp Glu Ser Lys His Cys Arg Thr Pro Leu Gly Ser 
65                  70                  75                  80  


Leu Phe Lys His Val Asn Val Asn Cys Leu Asp Asp Glu Leu Asp Ser 
                85                  90                  95      


Phe His Asp Leu Lys Lys Gln Glu Thr Glu Glu Glu Leu Ile Glu Asn 
            100                 105                 110         


Asp Tyr Arg Val Ser Thr Ser Lys Ile Thr Lys Gln Ser Phe Lys Glu 
        115                 120                 125             


Ile Glu Lys Val Ala Leu Pro Thr Asn Thr Thr Ser Ser Arg Pro Arg 
    130                 135                 140                 


Thr Glu Cys Cys Ser Asp Ala Gly Asp Ser Pro Leu Lys Pro Val Ser 
145                 150                 155                 160 


Cys Pro Lys Ser Lys Ala Ser Asp Lys Arg Ser Leu Leu Pro His Gln 
                165                 170                 175     


Ile Ser Gln Ile Tyr Asp Glu Leu Phe Gln Ile His Leu Lys Leu Gln 
            180                 185                 190         


Cys Glu Thr Ala Ala Gln Gln Lys Phe Ala Glu Glu Leu Gln Lys Arg 
        195                 200                 205             


Glu Arg Phe Leu Leu Glu Arg Glu Gln Leu Leu Phe Arg His Glu Asn 
    210                 215                 220                 


Ala Leu Ser Lys Ile Lys Gly Val Glu Glu Glu Val Leu Thr Arg Phe 
225                 230                 235                 240 


Gln Ile Ile Lys Glu Gln His Asp Ala Glu Val Glu His Leu Thr Glu 
                245                 250                 255     


Val Leu Lys Glu Lys Asn Lys Glu Thr Lys Arg Leu Arg Ser Ser Phe 
            260                 265                 270         


Asp Ala Leu Lys Glu Leu Asn Asp Thr Leu Lys Lys Gln Leu Asn Glu 
        275                 280                 285             


Ala Ser Glu Glu Asn Arg Lys Ile Asp Ile Gln Ala Lys Arg Val Gln 
    290                 295                 300                 


Ala Arg Leu Asp Asn Leu Gln Arg Lys Tyr Glu Phe Met Thr Ile Gln 
305                 310                 315                 320 


Arg Leu Lys Gly Ser Ser His Ala Val His Glu Met Lys Ser Leu Lys 
                325                 330                 335     


Gln Glu Lys Ala Pro Val Ser Lys Thr Tyr Lys Val Pro Leu Asn Gly 
            340                 345                 350         


Gln Val Tyr Glu Leu Leu Thr Val Phe Met Asp Trp Ile Ser Asp His 
        355                 360                 365             


His Leu Ser Lys Val Lys His Glu Glu Ser Gly Met Asp Gly Lys Lys 
    370                 375                 380                 


Pro Gln Leu Lys Phe Ala Ser Gln Arg Asn Asp Ile Gln Glu Lys Cys 
385                 390                 395                 400 


Val Lys Leu Leu Pro Leu Met Thr Glu Gln Leu Gln Trp Met Pro Phe 
                405                 410                 415     


Val Asn Ile Lys Leu His Glu Pro Phe Val Lys Phe Ile Tyr Trp Ser 
            420                 425                 430         


Leu Arg Gln Leu Asp Ala Gly Ala Gln His Ser Thr Met Thr Ser Thr 
        435                 440                 445             


Leu Arg Arg Leu Gly Glu Asp Ile Phe Lys Gly Val Val Thr Lys Gly 
    450                 455                 460                 


Ile Gln Asp Asn Ser Pro Gln His Ser Val Glu Asn Lys Pro Lys Thr 
465                 470                 475                 480 


Ala Ala Phe Phe Lys Ser Ser Asn Leu Pro Leu Arg Phe Leu Ser Thr 
                485                 490                 495     


Leu Ile Val Leu Lys Thr Val Thr Gln Ala Asp Tyr Leu Ala Gln Ala 
            500                 505                 510         


Phe Asp Ser Leu Cys Leu Asp Leu Lys Thr Glu Glu Gly Lys Thr Leu 
        515                 520                 525             


Phe Leu Glu Tyr Gln Ala Val Pro Val Ile Leu Ser His Leu Arg Ile 
    530                 535                 540                 


Ser Ser Lys Gly Leu Leu Ser Asn Val Ile Asp Ser Leu Leu Gln Met 
545                 550                 555                 560 


Thr Val Glu Ser Lys Ser Leu Gln Pro Phe Leu Glu Ala Cys Ser Asn 
                565                 570                 575     


Ser Leu Phe Phe Arg Thr Cys Ser Val Leu Leu Arg Ala Pro Lys Leu 
            580                 585                 590         


Asp Leu Gln Ile Leu Glu Lys Leu Ser Ile Ile Leu Gln Lys Leu Ser 
        595                 600                 605             


Lys Ile Lys Ser Asn Lys Lys Leu Phe Glu Leu Phe Thr Ile His Leu 
    610                 615                 620                 


Met Leu Gln Glu Ile Gln Arg Thr Thr Asn Pro Glu His Ala Phe Leu 
625                 630                 635                 640 


Cys Ile Asn Leu Asn Ser Thr Leu Phe Asn Leu Gly Leu Thr Lys Cys 
                645                 650                 655     


Asn Ser Leu Val Ser Ser Ala Ser Pro 
            660                 665 


<210>  8221
<211>  2261
<212>  DNA
<213>  Homosapiens

<400>  8221
ggccgcgtag cgccgcgggt ttgatgaacg cggttcccgg ggagactggt acggttgctg     60

tgtgctatgg agccgagggt cgtcaagcca ccggggcagg atttagtagt ggagagtctc    120

aaaagccgct acggactcgg gggcagctgc cccgacgagt atgatttttc aaatttttat    180

cagtctaagt ataagagaag aactctaacc tccccaggtg atttggatat ctactctgga    240

gataaagttg gttcatcgtt aaaatattct gatgaaagca agcattgtag aacaccattg    300

ggcagcttat tcaagcacgt aaatgtgaat tgcctagatg atgaactgga ttctttccat    360

gatttgaaga aacaggaaac agaagaagag ttaattgaaa atgattatag agttagtacc    420

tcgaaaataa ccaagcagtc ttttaaagaa atagaaaaag ttgccttgcc aactaatacg    480

acctcatcga gacctcggac tgagtgttgt agtgatgcag gtgactctcc tttgaaacct    540

gtcagctgtc caaaatctaa agcatcagac aagcggagtt tacttccaca tcagatcagt    600

cagatatatg acgaattatt tcagatacat ctgaaattgc agtgtgaaac tgcagcacaa    660

cagaaatttg ctgaagaact tcaaaagcga gaacgttttt tacttgaaag agaacaactg    720

cttttcagac atgaaaatgc cttgagtaaa attaaaggtg ttgaagaaga ggttcttaca    780

agatttcaaa ttataaaaga gcagcatgat gcagaagttg aacacttaac cgaagttctt    840

aaggaaaaga ataaagaaac caagagactg aggtcctctt ttgatgcatt gaaagaattg    900

aatgatacct taaaaaaaca gttaaatgaa gcaagtgaag aaaacaggaa gatagacatt    960

caggctaaaa gagttcaagc tcgtttagat aatttacaga ggaagtacga gtttatgaca   1020

atacagagat tgaaaggaag ttcccatgct gttcatgaaa tgaaaagttt aaaacaagaa   1080

aaagcaccag tttcaaaaac ttacaaggta ccacttaatg ggcaagttta tgaactttta   1140

actgtcttca tggactggat ttcggatcat catcttagca aagtgaaaca tgaagaatct   1200

ggaatggatg gtaaaaaacc acaactcaaa tttgcttccc agagaaatga tattcaggag   1260

aagtgtgtaa agcttttgcc tctaatgaca gagcagctac agtggatgcc atttgtgaat   1320

atcaaacttc acgagccttt tgtaaaattt atatattggt ccctaaggca gctagatgct   1380

ggagcacagc actcgactat gacatcaaca ttgaggagat tgggtgaaga catttttaaa   1440

ggagtggtaa ctaaaggaat tcaggataat tctccacagc attctgtgga gaataaacca   1500

aagacagctg ctttctttaa gagctccaat ttgccattga gatttttatc aaccttaatt   1560

gttctcaaaa cagtcactca agctgattac ctggctcagg catttgattc tctttgtttg   1620

gacttgaaga cagaagaagg aaaaaccttg tttttggagt atcaggctgt tccagtaata   1680

ttaagtcatc taagaatatc cagtaaagga ctcctgtcta atgttattga tagtttgctc   1740

cagatgacgg tggaatctag agtaataaga agctctttga actttttacg attcatctga   1800

tgcttcaaga aatacaaagg acaacaaacc cagagcatgc atttctctgt attaatctaa   1860

attcaactct gttcaatctg ggtttaacaa aatgtaactc cctggtctcc agtgcaagcc   1920

cttagactgg ctaatttttt aatatagtat atgtggtgct tatttataaa catgtagaaa   1980

ttaccaaagt aactacaatt ctaccaagta aagttatcag tagcatcatt tatcatgaaa   2040

aataaataat ttttttgaac tgtaaaaatg aaatctgtag aaggtattgg aacttttgga   2100

atgtttcagt tcaggtaagg taatactaat atacaagatg gcgtttctag aatgtatgac   2160

actgaagtga ctttttgtaa aaatatatta ggaaaattat ttcttaaaat tatgtgatta   2220

tttggaataa aattggtgct tatgtgagaa cagggttaaa t                       2261


<210>  8222
<211>  577
<212>  PRT
<213>  Homosapiens

<400>  8222

Met Glu Pro Arg Val Val Lys Pro Pro Gly Gln Asp Leu Val Val Glu 
1               5                   10                  15      


Ser Leu Lys Ser Arg Tyr Gly Leu Gly Gly Ser Cys Pro Asp Glu Tyr 
            20                  25                  30          


Asp Phe Ser Asn Phe Tyr Gln Ser Lys Tyr Lys Arg Arg Thr Leu Thr 
        35                  40                  45              


Ser Pro Gly Asp Leu Asp Ile Tyr Ser Gly Asp Lys Val Gly Ser Ser 
    50                  55                  60                  


Leu Lys Tyr Ser Asp Glu Ser Lys His Cys Arg Thr Pro Leu Gly Ser 
65                  70                  75                  80  


Leu Phe Lys His Val Asn Val Asn Cys Leu Asp Asp Glu Leu Asp Ser 
                85                  90                  95      


Phe His Asp Leu Lys Lys Gln Glu Thr Glu Glu Glu Leu Ile Glu Asn 
            100                 105                 110         


Asp Tyr Arg Val Ser Thr Ser Lys Ile Thr Lys Gln Ser Phe Lys Glu 
        115                 120                 125             


Ile Glu Lys Val Ala Leu Pro Thr Asn Thr Thr Ser Ser Arg Pro Arg 
    130                 135                 140                 


Thr Glu Cys Cys Ser Asp Ala Gly Asp Ser Pro Leu Lys Pro Val Ser 
145                 150                 155                 160 


Cys Pro Lys Ser Lys Ala Ser Asp Lys Arg Ser Leu Leu Pro His Gln 
                165                 170                 175     


Ile Ser Gln Ile Tyr Asp Glu Leu Phe Gln Ile His Leu Lys Leu Gln 
            180                 185                 190         


Cys Glu Thr Ala Ala Gln Gln Lys Phe Ala Glu Glu Leu Gln Lys Arg 
        195                 200                 205             


Glu Arg Phe Leu Leu Glu Arg Glu Gln Leu Leu Phe Arg His Glu Asn 
    210                 215                 220                 


Ala Leu Ser Lys Ile Lys Gly Val Glu Glu Glu Val Leu Thr Arg Phe 
225                 230                 235                 240 


Gln Ile Ile Lys Glu Gln His Asp Ala Glu Val Glu His Leu Thr Glu 
                245                 250                 255     


Val Leu Lys Glu Lys Asn Lys Glu Thr Lys Arg Leu Arg Ser Ser Phe 
            260                 265                 270         


Asp Ala Leu Lys Glu Leu Asn Asp Thr Leu Lys Lys Gln Leu Asn Glu 
        275                 280                 285             


Ala Ser Glu Glu Asn Arg Lys Ile Asp Ile Gln Ala Lys Arg Val Gln 
    290                 295                 300                 


Ala Arg Leu Asp Asn Leu Gln Arg Lys Tyr Glu Phe Met Thr Ile Gln 
305                 310                 315                 320 


Arg Leu Lys Gly Ser Ser His Ala Val His Glu Met Lys Ser Leu Lys 
                325                 330                 335     


Gln Glu Lys Ala Pro Val Ser Lys Thr Tyr Lys Val Pro Leu Asn Gly 
            340                 345                 350         


Gln Val Tyr Glu Leu Leu Thr Val Phe Met Asp Trp Ile Ser Asp His 
        355                 360                 365             


His Leu Ser Lys Val Lys His Glu Glu Ser Gly Met Asp Gly Lys Lys 
    370                 375                 380                 


Pro Gln Leu Lys Phe Ala Ser Gln Arg Asn Asp Ile Gln Glu Lys Cys 
385                 390                 395                 400 


Val Lys Leu Leu Pro Leu Met Thr Glu Gln Leu Gln Trp Met Pro Phe 
                405                 410                 415     


Val Asn Ile Lys Leu His Glu Pro Phe Val Lys Phe Ile Tyr Trp Ser 
            420                 425                 430         


Leu Arg Gln Leu Asp Ala Gly Ala Gln His Ser Thr Met Thr Ser Thr 
        435                 440                 445             


Leu Arg Arg Leu Gly Glu Asp Ile Phe Lys Gly Val Val Thr Lys Gly 
    450                 455                 460                 


Ile Gln Asp Asn Ser Pro Gln His Ser Val Glu Asn Lys Pro Lys Thr 
465                 470                 475                 480 


Ala Ala Phe Phe Lys Ser Ser Asn Leu Pro Leu Arg Phe Leu Ser Thr 
                485                 490                 495     


Leu Ile Val Leu Lys Thr Val Thr Gln Ala Asp Tyr Leu Ala Gln Ala 
            500                 505                 510         


Phe Asp Ser Leu Cys Leu Asp Leu Lys Thr Glu Glu Gly Lys Thr Leu 
        515                 520                 525             


Phe Leu Glu Tyr Gln Ala Val Pro Val Ile Leu Ser His Leu Arg Ile 
    530                 535                 540                 


Ser Ser Lys Gly Leu Leu Ser Asn Val Ile Asp Ser Leu Leu Gln Met 
545                 550                 555                 560 


Thr Val Glu Ser Arg Val Ile Arg Ser Ser Leu Asn Phe Leu Arg Phe 
                565                 570                 575     


Ile 
    


<210>  8223
<211>  2920
<212>  DNA
<213>  Homosapiens

<400>  8223
ggccgcgtag cgccgcgggt ttgatgaacg cggttcccgg ggagactggt acggttgctg     60

tgtgctatgg agccgagggt cgtcaagcca ccggggcagg atttagtagt ggagagtctc    120

aaaagccgct acggactcgg gggcagctgc cccgacgagt atgatttttc aaatttttat    180

cagtctaagt ataagagaag aactctaacc tccccaggtg atttggatat ctactctgga    240

gataaagttg gttcatcgtt aaaatattct gatgaaagca agcattgtag aacaccattg    300

ggcagcttat tcaagcacgt aaatgtgaat tgcctagatg atgaactgga ttctttccat    360

gatttgaaga aacaggaaac agaagaagag ttaattgaaa atgattatag agttagtacc    420

tcgaaaataa ccaagcagtc ttttaaagaa atagaaaaag ttgccttgcc aactaatacg    480

acctcatcga gacctcggac tgagtgttgt agtgatgcag gtgactctcc tttgaaacct    540

gtcagctgtc caaaatctaa agcatcagac aagcggagtt tacttccaca tcagatcagt    600

cagatatatg acgaattatt tcagatacat ctgaaattgc agtgtgaaac tgcagcacaa    660

cagaaatttg ctgaagaact tcaaaagcga gaacgttttt tacttgaaag agaacaactg    720

cttttcagac atgaaaatgc cttgagtaaa attaaaggtg ttgaagaaga ggttcttaca    780

agatttcaaa ttataaaaga gcagcatgat gcagaagttg aacacttaac cgaagttctt    840

aaggaaaaga ataaagaaac caagagactg aggtcctctt ttgatgcatt gaaagaattg    900

aatgatacct taaaaaaaca gttaaatgaa gcaagtgaag aaaacaggaa gatagacatt    960

caggctaaaa gagttcaagc tcgtttagat aatttacaga ggaagtacga gtttatgaca   1020

atacagagat tgaaaggaag ttcccatgct gttcatgaaa tgaaaagttt aaaacaagaa   1080

aaagcaccag tttcaaaaac ttacaaggta ccacttaatg ggcaagttta tgaactttta   1140

actgtcttca tggactggat ttcggatcat catcttagca aagtgaaaca tgaagaatct   1200

ggaatggatg gtaaaaaacc acaactcaaa tttgcttccc agagaaatga tattcaggag   1260

aagtgtgtaa agcttttgcc tctaatgaca gagcagctac agtggatgcc atttgtgaat   1320

atcaaacttc acgagccttt tgtaaaattt atatattggt ccctaaggca gctagatgct   1380

ggagcacagc actcgactat gacatcaaca ttgaggagat tgggtgaaga catttttaaa   1440

ggagtggtaa ctaaaggaat tcaggataat tctccacagc attctgtgga gaataaacca   1500

aagacagctg ctttctttaa gagctccaat ttgccattga gatttttatc aaccttaatt   1560

gttctcaaaa cagtcactca agctgattac ctggctcagg catttgattc tctttgtttg   1620

gacttgaaga cagaagaagg aaaaaccttg tttttggagt atcaggctgt tccagtaata   1680

ttaagtcatc taagaatatc cagtaaagga ctcctgtcta atgttattga tagtttgctc   1740

cagatgacgg tggaatctaa atccttgcag cctttcctgg aagcctgtag caactcttta   1800

ttttttcgta cttgctctgt gctgcttcga gcccctaagc ttgatcttca aatactagaa   1860

aaactcagta ttattttaca gaaactttcc aaaatcaaga gtaataagaa gctctttgaa   1920

ctttttacga ttcatctgat gcttcaagaa atacaaagga caacaaaccc agagcatgca   1980

tttctctgta ttaatctaaa ttcaactctg ttcaatctgg gtttaacaaa atgtaactcc   2040

ctggtctcca gtgcaagccc ttagactggc taatttttta atatagtata tgtggtgctt   2100

atttataaac atgtagaaat taccaaagta actacaattc taccaagtaa agttatcagt   2160

agcatcattt atcatgaaaa ataaataatt tttttgaact gtaaaaatga aatctgtaga   2220

aggtattgga acttttggaa tgtttcagtt caggtaaggt aatactaata tacaagatgg   2280

cgtttctaga atgtatgaca ctgaagtgac tttttgtaaa aatatattag gaaaattatt   2340

tcttaaaatt atgtgattat ttggaataaa attggtgctt atgtgagaac agggttaaat   2400

aatactgtct ttctattttc ctaatatatt agaatccttg cttttgaaag caaaaatgta   2460

tatctttaaa ctatcatctt gataccataa cttttctata tactgtatcc tagattaaca   2520

gatgttgatt ttttttttat tgtgctcttt gtgggataga aaaagttttt tattatgctg   2580

ttcacaggtt taaaaacttt tgttttcaaa ataattatta ctggagcatg tatatacaag   2640

gcaagacatt ttttaaacat tgaaaggtaa acaaaaataa tcgtcctgtt accagagata   2700

tctcttggta tagccaaaga tgagtaaagt ggccacaggt ctgggtgaag taaaggtggt   2760

aaaacttggg acttaggaca ggatactgag aaacattgtt ttaaagagtc ataaaatcat   2820

atatgatcag tgtataatct cagtttcagg agttagaaga aattttcaag aaactattgg   2880

gcctcttcaa aaaaatacca gaaaatgtgc catttttgaa                         2920


<210>  8224
<211>  665
<212>  PRT
<213>  Homosapiens

<400>  8224

Met Glu Pro Arg Val Val Lys Pro Pro Gly Gln Asp Leu Val Val Glu 
1               5                   10                  15      


Ser Leu Lys Ser Arg Tyr Gly Leu Gly Gly Ser Cys Pro Asp Glu Tyr 
            20                  25                  30          


Asp Phe Ser Asn Phe Tyr Gln Ser Lys Tyr Lys Arg Arg Thr Leu Thr 
        35                  40                  45              


Ser Pro Gly Asp Leu Asp Ile Tyr Ser Gly Asp Lys Val Gly Ser Ser 
    50                  55                  60                  


Leu Lys Tyr Ser Asp Glu Ser Lys His Cys Arg Thr Pro Leu Gly Ser 
65                  70                  75                  80  


Leu Phe Lys His Val Asn Val Asn Cys Leu Asp Asp Glu Leu Asp Ser 
                85                  90                  95      


Phe His Asp Leu Lys Lys Gln Glu Thr Glu Glu Glu Leu Ile Glu Asn 
            100                 105                 110         


Asp Tyr Arg Val Ser Thr Ser Lys Ile Thr Lys Gln Ser Phe Lys Glu 
        115                 120                 125             


Ile Glu Lys Val Ala Leu Pro Thr Asn Thr Thr Ser Ser Arg Pro Arg 
    130                 135                 140                 


Thr Glu Cys Cys Ser Asp Ala Gly Asp Ser Pro Leu Lys Pro Val Ser 
145                 150                 155                 160 


Cys Pro Lys Ser Lys Ala Ser Asp Lys Arg Ser Leu Leu Pro His Gln 
                165                 170                 175     


Ile Ser Gln Ile Tyr Asp Glu Leu Phe Gln Ile His Leu Lys Leu Gln 
            180                 185                 190         


Cys Glu Thr Ala Ala Gln Gln Lys Phe Ala Glu Glu Leu Gln Lys Arg 
        195                 200                 205             


Glu Arg Phe Leu Leu Glu Arg Glu Gln Leu Leu Phe Arg His Glu Asn 
    210                 215                 220                 


Ala Leu Ser Lys Ile Lys Gly Val Glu Glu Glu Val Leu Thr Arg Phe 
225                 230                 235                 240 


Gln Ile Ile Lys Glu Gln His Asp Ala Glu Val Glu His Leu Thr Glu 
                245                 250                 255     


Val Leu Lys Glu Lys Asn Lys Glu Thr Lys Arg Leu Arg Ser Ser Phe 
            260                 265                 270         


Asp Ala Leu Lys Glu Leu Asn Asp Thr Leu Lys Lys Gln Leu Asn Glu 
        275                 280                 285             


Ala Ser Glu Glu Asn Arg Lys Ile Asp Ile Gln Ala Lys Arg Val Gln 
    290                 295                 300                 


Ala Arg Leu Asp Asn Leu Gln Arg Lys Tyr Glu Phe Met Thr Ile Gln 
305                 310                 315                 320 


Arg Leu Lys Gly Ser Ser His Ala Val His Glu Met Lys Ser Leu Lys 
                325                 330                 335     


Gln Glu Lys Ala Pro Val Ser Lys Thr Tyr Lys Val Pro Leu Asn Gly 
            340                 345                 350         


Gln Val Tyr Glu Leu Leu Thr Val Phe Met Asp Trp Ile Ser Asp His 
        355                 360                 365             


His Leu Ser Lys Val Lys His Glu Glu Ser Gly Met Asp Gly Lys Lys 
    370                 375                 380                 


Pro Gln Leu Lys Phe Ala Ser Gln Arg Asn Asp Ile Gln Glu Lys Cys 
385                 390                 395                 400 


Val Lys Leu Leu Pro Leu Met Thr Glu Gln Leu Gln Trp Met Pro Phe 
                405                 410                 415     


Val Asn Ile Lys Leu His Glu Pro Phe Val Lys Phe Ile Tyr Trp Ser 
            420                 425                 430         


Leu Arg Gln Leu Asp Ala Gly Ala Gln His Ser Thr Met Thr Ser Thr 
        435                 440                 445             


Leu Arg Arg Leu Gly Glu Asp Ile Phe Lys Gly Val Val Thr Lys Gly 
    450                 455                 460                 


Ile Gln Asp Asn Ser Pro Gln His Ser Val Glu Asn Lys Pro Lys Thr 
465                 470                 475                 480 


Ala Ala Phe Phe Lys Ser Ser Asn Leu Pro Leu Arg Phe Leu Ser Thr 
                485                 490                 495     


Leu Ile Val Leu Lys Thr Val Thr Gln Ala Asp Tyr Leu Ala Gln Ala 
            500                 505                 510         


Phe Asp Ser Leu Cys Leu Asp Leu Lys Thr Glu Glu Gly Lys Thr Leu 
        515                 520                 525             


Phe Leu Glu Tyr Gln Ala Val Pro Val Ile Leu Ser His Leu Arg Ile 
    530                 535                 540                 


Ser Ser Lys Gly Leu Leu Ser Asn Val Ile Asp Ser Leu Leu Gln Met 
545                 550                 555                 560 


Thr Val Glu Ser Lys Ser Leu Gln Pro Phe Leu Glu Ala Cys Ser Asn 
                565                 570                 575     


Ser Leu Phe Phe Arg Thr Cys Ser Val Leu Leu Arg Ala Pro Lys Leu 
            580                 585                 590         


Asp Leu Gln Ile Leu Glu Lys Leu Ser Ile Ile Leu Gln Lys Leu Ser 
        595                 600                 605             


Lys Ile Lys Ser Asn Lys Lys Leu Phe Glu Leu Phe Thr Ile His Leu 
    610                 615                 620                 


Met Leu Gln Glu Ile Gln Arg Thr Thr Asn Pro Glu His Ala Phe Leu 
625                 630                 635                 640 


Cys Ile Asn Leu Asn Ser Thr Leu Phe Asn Leu Gly Leu Thr Lys Cys 
                645                 650                 655     


Asn Ser Leu Val Ser Ser Ala Ser Pro 
            660                 665 


<210>  8225
<211>  2377
<212>  DNA
<213>  Homosapiens

<400>  8225
gcgtagcgcc gcgggtttga tgaacgcggt tcccggggag actggtacgg ttgctgtgtg     60

ctatggagcc gagggtcgtc aagccaccgg ggcaggattt agtagtggag agtctcaaaa    120

gccgctacgg actcgggggc agctgccccg acgagtatga tttttcaaat ttttatcagt    180

ctaagtataa gagaagaact ctaacctccc caggtgattt ggatatctac tctggagata    240

aagttggttc atcgttaaaa tattctgatg aaagcaagca ttgtagaaca ccattgggca    300

gcttattcaa gcacgtaaat gtgaattgtt taaaaaatgt ttttacattt tttctcagtt    360

atgctgttaa tatttgaaaa gcagttttat ctttttaaag tgctatagta aacttctaga    420

ttgctgtgat acaattattt ttttaaagcc tagatgatga actggattct ttccatgatt    480

tgaagaaaca ggaaacagaa gaagagttaa ttgaaaatga ttatagagtt agtacctcga    540

aaataaccaa gcagtctttt aaagaaatag aaaaagttgc cttgccaact aatacgacct    600

catcgagacc tcggactgag tgttgtagtg atgcaggtga ctctcctttg aaacctgtca    660

gctgtccaaa atctaaagca tcagacaagc ggagtttact tccacatcag atcagtcaga    720

tatatgacga attatttcag atacatctga aattgcagtg tgaaactgca gcacaacaga    780

aatttgctga agaacttcaa aagcgagaac gttttttact tgaaagagaa caactgcttt    840

tcagacatga aaatgccttg agtaaaatta aaggtgttga agaagaggtt cttacaagat    900

ttcaaattat aaaagagcag catgatgcag aagttgaaca cttaaccgaa gttcttaagg    960

aaaagaataa agaaaccaag agactgaggt cctcttttga tgcattgaaa gaattgaatg   1020

ataccttaaa aaaacagtta aatgaagcaa gtgaagaaaa caggaagata gacattcagg   1080

ctaaaagagt tcaagctcgt ttagataatt tacagaggaa gtacgagttt atgacaatac   1140

agagattgaa aggaagttcc catgctgttc atgaaatgaa aagtttaaaa caagaaaaag   1200

caccagtttc aaaaacttac aaggtaccac ttaatgggca agtttatgaa cttttaactg   1260

tcttcatgga ctggatttcg gatcatcatc ttagcaaagt gaaacatgaa gaatctggaa   1320

tggatggtaa aaaaccacaa ctcaaatttg cttcccagag aaatgatatt caggagaagt   1380

gtgtaaagct tttgcctcta atgacagagc agctacagtg gatgccattt gtgaatatca   1440

aacttcacga gccttttgta aaatttatat attggtccct aaggcagcta gatgctggag   1500

cacagcactc gactatgaca tcaacattga ggagattggg tgaagacatt tttaaaggag   1560

tggtaactaa aggaattcag gataattctc cacagcattc tgtggagaat aaaccaaaga   1620

cagctgcttt ctttaagagc tccaatttgc cattgagatt tttatcaacc ttaattgttc   1680

tcaaaacagt cactcaagct gattacctgg ctcaggcatt tgattctctt tgtttggact   1740

tgaagacaga agaaggaaaa accttgtttt tggagtatca ggctgttcca gtaatattaa   1800

gtcatctaag aatatccagt aaaggactcc tgtctaatgt tattgatagt ttgctccaga   1860

tgacggtgga atctagagta ataagaagct ctttgaactt tttacgattc atctgatgct   1920

tcaagaaata caaaggacaa caaacccaga gcatgcattt ctctgtatta atctaaattc   1980

aactctgttc aatctgggtt taacaaaatg taactccctg gtctccagtg caagccctta   2040

gactggctaa ttttttaata tagtatatgt ggtgcttatt tataaacatg tagaaattac   2100

caaagtaact acaattctac caagtaaagt tatcagtagc atcatttatc atgaaaaata   2160

aataattttt ttgaactgta aaaatgaaat ctgtagaagg tattggaact tttggaatgt   2220

ttcagttcag gtaaggtaat actaatatac aagatggcgt ttctagaatg tatgacactg   2280

aagtgacttt ttgtaaaaat atattaggaa aattatttct taaaattatg tgattatttg   2340

gaataaaatt ggtgcttatg tgagaacagg gttaaat                            2377


<210>  8226
<211>  261
<212>  PRT
<213>  Homosapiens

<400>  8226

Met Thr Ile Gln Arg Leu Lys Gly Ser Ser His Ala Val His Glu Met 
1               5                   10                  15      


Lys Ser Leu Lys Gln Glu Lys Ala Pro Val Ser Lys Thr Tyr Lys Val 
            20                  25                  30          


Pro Leu Asn Gly Gln Val Tyr Glu Leu Leu Thr Val Phe Met Asp Trp 
        35                  40                  45              


Ile Ser Asp His His Leu Ser Lys Val Lys His Glu Glu Ser Gly Met 
    50                  55                  60                  


Asp Gly Lys Lys Pro Gln Leu Lys Phe Ala Ser Gln Arg Asn Asp Ile 
65                  70                  75                  80  


Gln Glu Lys Cys Val Lys Leu Leu Pro Leu Met Thr Glu Gln Leu Gln 
                85                  90                  95      


Trp Met Pro Phe Val Asn Ile Lys Leu His Glu Pro Phe Val Lys Phe 
            100                 105                 110         


Ile Tyr Trp Ser Leu Arg Gln Leu Asp Ala Gly Ala Gln His Ser Thr 
        115                 120                 125             


Met Thr Ser Thr Leu Arg Arg Leu Gly Glu Asp Ile Phe Lys Gly Val 
    130                 135                 140                 


Val Thr Lys Gly Ile Gln Asp Asn Ser Pro Gln His Ser Val Glu Asn 
145                 150                 155                 160 


Lys Pro Lys Thr Ala Ala Phe Phe Lys Ser Ser Asn Leu Pro Leu Arg 
                165                 170                 175     


Phe Leu Ser Thr Leu Ile Val Leu Lys Thr Val Thr Gln Ala Asp Tyr 
            180                 185                 190         


Leu Ala Gln Ala Phe Asp Ser Leu Cys Leu Asp Leu Lys Thr Glu Glu 
        195                 200                 205             


Gly Lys Thr Leu Phe Leu Glu Tyr Gln Ala Val Pro Val Ile Leu Ser 
    210                 215                 220                 


His Leu Arg Ile Ser Ser Lys Gly Leu Leu Ser Asn Val Ile Asp Ser 
225                 230                 235                 240 


Leu Leu Gln Met Thr Val Glu Ser Arg Val Ile Arg Ser Ser Leu Asn 
                245                 250                 255     


Phe Leu Arg Phe Ile 
            260     


<210>  8227
<211>  2897
<212>  DNA
<213>  Homosapiens

<400>  8227
gcgtagcgcc gcgggtttga tgaacgcggt tcccggggag actggtacgg ttgctgtgtg     60

ctatggagcc gagggtcgtc aagccaccgg ggcaggattt agtagtggag agtctcaaaa    120

gccgctacgg actcgggggc agctgccccg acgagtatga tttttcaaat ttttatcagt    180

ctaagtataa gagaagaact ctaacctccc caggtgattt ggatatctac tctggagata    240

aagttggttc atcgttaaaa tattctgatg aaagcaagca ttgtagaaca ccattgggca    300

gcttattcaa gcacgtaaat gtgaattgtt taaaaaatgt ttttacattt tttctcagtt    360

atgctgttaa tatttgaaaa gcagttttat ctttttaaag tgctatagta aacttctaga    420

ttgctgtgat acaattattt ttttaaagcc tagatgatga actggattct ttccatgatt    480

tgaagaaaca ggaaacagaa gaagagttaa ttgaaaatga ttatagagtt agtacctcga    540

aaataaccaa gcagtctttt aaagaaatag aaaaagttgc cttgccaact aatacgacct    600

catcgagacc tcggactgag tgttgtagtg atgcaggtga ctctcctttg aaacctgtca    660

gctgtccaaa atctaaagca tcagacaagc ggagtttact tccacatcag atcagtcaga    720

tatatgacga attatttcag atacatctga aattgcagtg tgaaactgca gcacaacaga    780

aatttgctga agaacttcaa aagcgagaac gttttttact tgaaagagaa caactgcttt    840

tcagacatga aaatgccttg agtaaaatta aaggtgttga agaagaggtt cttacaagat    900

ttcaaattat aaaagagcag catgatgcag aagttgaaca cttaaccgaa gttcttaagg    960

aaaagaataa agaaaccaag agactgaggt cctcttttga tgcattgaaa gaattgaatg   1020

ataccttaaa aaaacagtta aatgaagcaa gtgaagaaaa caggaagata gacattcagg   1080

ctaaaagagt tcaagctcgt ttagataatt tacagaggaa gtacgagttt atgacaatac   1140

agagattgaa aggaagttcc catgctgttc atgaaatgaa aagtttaaaa caagaaaaag   1200

caccagtttc aaaaacttac aaggtaccac ttaatgggca agtttatgaa cttttaactg   1260

tcttcatgga ctggatttcg gatcatcatc ttagcaaagt gaaacatgaa gaatctggaa   1320

tggatggtaa aaaaccacaa ctcaaatttg cttcccagag aaatgatatt caggagaagt   1380

gtgtaaagct tttgcctcta atgacagagc agctacagtg gatgccattt gtgaatatca   1440

aacttcacga gccttttgta aaatttatat attggtccct aaggcagcta gatgctggag   1500

cacagcactc gactatgaca tcaacattga ggagattggg tgaagacatt tttaaaggag   1560

tggtaactaa aggaattcag gataattctc cacagcattc tgtggagaat aaaccaaaga   1620

cagctgcttt ctttaagagc tccaatttgc cattgagatt tttatcaacc ttaattgttc   1680

tcaaaacagt cactcaagct gattacctgg ctcaggcatt tgattctctt tgtttggact   1740

tgaagacaga agaaggaaaa accttgtttt tggagtatca ggctgttcca gtaatattaa   1800

gtcatctaag aatatccagt aaaggactcc tgtctaatgt tattgatagt ttgctccaga   1860

tgacggtgga atctagagta ataagaagct ctttgaactt tttacgattc atctgatgct   1920

tcaagaaata caaaggacaa caaacccaga gcatgcattt ctctgtatta atctaaattc   1980

aactctgttc aatctgggtt taacaaaatg taactccctg gtctccagtg caagccctta   2040

gactggctaa ttttttaata tagtatatgt ggtgcttatt tataaacatg tagaaattac   2100

caaagtaact acaattctac caagtaaagt tatcagtagc atcatttatc atgaaaaata   2160

aataattttt ttgaactgta aaaatgaaat ctgtagaagg tattggaact tttggaatgt   2220

ttcagttcag gtaaggtaat actaatatac aagatggcgt ttctagaatg tatgacactg   2280

aagtgacttt ttgtaaaaat atattaggaa aattatttct taaaattatg tgattatttg   2340

gaataaaatt ggtgcttatg tgagaacagg gttaaataat actgtctttc tattttccta   2400

atatattaga atccttgctt ttgaaagcaa aaatgtatat ctttaaacta tcatcttgat   2460

accataactt ttctatatac tgtatcctag attaacagat gttgattttt tttttattgt   2520

gctctttgtg ggatagaaaa agttttttat tatgctgttc acaggtttaa aaacttttgt   2580

tttcaaaata attattactg gagcatgtat atacaaggca agacattttt taaacattga   2640

aaggtaaaca aaaataatcg tcctgttacc agagatatct cttggtatag ccaaagatga   2700

gtaaagtggc cacaggtctg ggtgaagtaa aggtggtaaa acttgggact taggacagga   2760

tactgagaaa cattgtttta aagagtcata aaatcatata tgatcagtgt ataatctcag   2820

tttcaggagt tagaagaaat tttcaagaaa ctattgggcc tcttcaaaaa aataccagaa   2880

aatgtgccat ttttgaa                                                  2897


<210>  8228
<211>  261
<212>  PRT
<213>  Homosapiens

<400>  8228

Met Thr Ile Gln Arg Leu Lys Gly Ser Ser His Ala Val His Glu Met 
1               5                   10                  15      


Lys Ser Leu Lys Gln Glu Lys Ala Pro Val Ser Lys Thr Tyr Lys Val 
            20                  25                  30          


Pro Leu Asn Gly Gln Val Tyr Glu Leu Leu Thr Val Phe Met Asp Trp 
        35                  40                  45              


Ile Ser Asp His His Leu Ser Lys Val Lys His Glu Glu Ser Gly Met 
    50                  55                  60                  


Asp Gly Lys Lys Pro Gln Leu Lys Phe Ala Ser Gln Arg Asn Asp Ile 
65                  70                  75                  80  


Gln Glu Lys Cys Val Lys Leu Leu Pro Leu Met Thr Glu Gln Leu Gln 
                85                  90                  95      


Trp Met Pro Phe Val Asn Ile Lys Leu His Glu Pro Phe Val Lys Phe 
            100                 105                 110         


Ile Tyr Trp Ser Leu Arg Gln Leu Asp Ala Gly Ala Gln His Ser Thr 
        115                 120                 125             


Met Thr Ser Thr Leu Arg Arg Leu Gly Glu Asp Ile Phe Lys Gly Val 
    130                 135                 140                 


Val Thr Lys Gly Ile Gln Asp Asn Ser Pro Gln His Ser Val Glu Asn 
145                 150                 155                 160 


Lys Pro Lys Thr Ala Ala Phe Phe Lys Ser Ser Asn Leu Pro Leu Arg 
                165                 170                 175     


Phe Leu Ser Thr Leu Ile Val Leu Lys Thr Val Thr Gln Ala Asp Tyr 
            180                 185                 190         


Leu Ala Gln Ala Phe Asp Ser Leu Cys Leu Asp Leu Lys Thr Glu Glu 
        195                 200                 205             


Gly Lys Thr Leu Phe Leu Glu Tyr Gln Ala Val Pro Val Ile Leu Ser 
    210                 215                 220                 


His Leu Arg Ile Ser Ser Lys Gly Leu Leu Ser Asn Val Ile Asp Ser 
225                 230                 235                 240 


Leu Leu Gln Met Thr Val Glu Ser Arg Val Ile Arg Ser Ser Leu Asn 
                245                 250                 255     


Phe Leu Arg Phe Ile 
            260     


<210>  8229
<211>  4216
<212>  DNA
<213>  Homosapiens

<400>  8229
ggggcagacg gccggagagc caggtgtgcc agggacctat ggcagcaggg ctgaacgtgc     60

ccgctccagc ctctccagtg ctgggagaga cctctagatg gtgcaggtga gtttgcaatg    120

agggaaagcc cctcggcaag gactgagttt ccaaacttgc agacagggca gggagcggtc    180

aaggaagagt tcccgggaag ccctttaaac ggaaaggaag cggggctagt gtcagagagg    240

tgtgccaggt cccaggcagc cctgctggcc cctaaggaca tagagtacct gcttctgaga    300

gggctgccac ggtggccacc tgtgaagcct gtcacccaga actggatggt acctgacttt    360

cttcatagac ccatcttctg ctgggactga agctgacctc caacagaagc caggtgagcc    420

cttgggagag gatggcccat gtgggggact gcacgcagac gccctggctc cccgtcctgg    480

tggtgtctct gatgtgctca gcccgagcgg aatactcaaa ctgcggtgag aacgagtact    540

acaaccagac tacggggctg tgccaggagt gccccccgtg tgggccggga gaggagccct    600

acctgtcctg tggctacggc accaaagacg aggactacgg ctgcgtcccc tgcccggcgg    660

agaagttttc caaaggaggc taccagatat gcaggcgtca caaagactgt gagggcttct    720

tccgggccac cgtgctgaca ccaggggaca tggagaatga cgctgagtgt ggcccttgcc    780

tccctggcta ctacatgctg gagaacagac cgaggaacat ctatggcatg gtctgctact    840

cctgcctcct ggcacccccc aacaccaagg aatgtgtggg agccacttca ggagcttctg    900

ccaacttccc tggcacctcg ggcagcagca ccctgtctcc cttccagcac gcccacaaag    960

aactctcagg ccaaggacac ctggccactg ccctgatcat tgcaatgtcc accatcttca   1020

tcatggccat cgccatcgtc ctcatcatca tgttctacat cctgaagaca aagccctctg   1080

ccccagcctg ttgcaccagc cacccgggga agagcgtgga ggcccaagtg agcaaggacg   1140

aggagaagaa agaggcccca gacaacgtgg tgatgttctc cgagaaggat gaatttgaga   1200

agctgacagc aactccagca aagcccacca agagcgagaa cgatgcctca tccgagaatg   1260

agcagctgct gagccggagc gtcgacagtg atgaggagcc cgcccctgac aagcagggct   1320

ccccggagct gtgcctgctg tcgctggttc acctggccag ggagaagtct gccaccagca   1380

acaagtcagc cgggattcaa agccggagga aaaagatcct cgatgtgtat gccaacgtgt   1440

gtggagtcgt ggaaggtctt agccccacgg agctgccatt tgattgcctc gagaagacta   1500

gccgaatgct cagctccacg tacaactctg agaaggctgt tgtgaaaacg tggcgccacc   1560

tcgccgagag cttcggcctg aagagggatg agattggggg catgacagac ggcatgcaac   1620

tctttgaccg catcagcacg gcaggctaca gcatccctga gctactcaca aaactggtgc   1680

agattgagcg gctggatgct gtggagtcct tgtgtgcaga catactggag tgggcggggg   1740

ttgtgccacc tgcctcccag ccacatgctg catcctgaaa agcatgcctg tgggctgtcc   1800

tcccaggaca agccaaggag ccaacgaggg ctctggagct gtgagtggtg ccaaaagact   1860

gccaagaatc aaggcttttg tgatatgtca ccgtatgcct taggatgttc aaggagccag   1920

acgaaataag gcctgtcttc caatttaacc aaagataaag gactagagcc gggatacttt   1980

cagatgctcg cctgtacctc accaggcaga gtaaatatct actcactcat acagccagcc   2040

caccagccca ccattaactc actgaacaat gagacaatgt tgaggactca aatgaatcaa   2100

accccgtggg aatgacagaa gtgaagaatc tggtccctgt ctttaaggag tttgcactcc   2160

agtagaagac agaaggaacg tatgtttaca aaccacttca ctggaagacg tcaaacaagc   2220

tgaatgaagg ggcgcttaga aaacgttaat agaagttcta agcgggagat gactccctac   2280

tgggatgatg aaggatggca tcctagtgaa gaagcagctc aaacattttg ataaaatggc   2340

aacaaaatgc agacaccctg ctccaggtat tatttcaggt ttagtacaag tctgttaata   2400

ccctatgtgg tttcattagg ataacttttt acctatcctt gaggtcatcc atattcttac   2460

aggccttcca gtcaataatg gaagagctca ctctatacaa aaccaatatg caaggcatgt   2520

gtttgtccaa gcaattggat gtgtgcagta gccaatttca tttactgcat tactctttgg   2580

cctgggaacc ctgtggtctg cactacatgt gaatggcctt ccacttcagt cttaggcaga   2640

tttgaccttt taggggcagc aatgctgaag gacacagcaa tttaaattat aatgtgtcag   2700

gctgtgtttt cacttcaaac atgtatgagt agtcagctgt aattagagaa atgatgactt   2760

cctaagagtt cagccacgca taattctaga tttcaagagc atctaagact tgtggattag   2820

cctcatggca tgagagtttc agactcagcc ttctgagcca gtcagggaaa gtggagttct   2880

gcagcgcaaa tgagagcctg ggcttgatgt cgagggagct ggcttctagt tgtgccacct   2940

tgggccttgt cttttcctct ctctgcctca gtttctcgtc tgccaatgag atgttagtta   3000

gtgattctat aattggggca ggtagggttc aggtgagcaa aaagaaagtg gagctatagg   3060

aaatgccagg cctttgaggt gctctatgga agtcaacaca gtgtggtttg tccatttaaa   3120

tgggaataaa aacagaaaaa ctcagacttg gcattttcac aataactgca atggtttgac   3180

ataacattta taggcagaaa gttaataaac tggcattgtt cttggcatat tattgtacta   3240

tccctgtaac tgccaagagc tcaggagcca ggctagtgat cacaccaggg gttagagttc   3300

actgctgaac tccctgatgg caggtctgtg tttattacta cattaaaaca aagtctctga   3360

cttataaagc gaggttgtaa aaattacaag ttgcatgact gaaaaaatgc tttaggggga   3420

aaatcagtca tatctttaac accaacaagc aatttcccac caacgaatgt agtacatact   3480

gtgagaggat cataatgagg tcctgaatat ttaatatcat catttactgt gtctgtttgc   3540

tgctgttttt cgaacctatt tggtttaccc tgcaagctaa atactccacg gcagagctta   3600

attatccttt taattcctct ttgaaatcct gtggtgcccc cttccccctg ccttgtgatg   3660

atgatgagtg agtctcccct taattagact gcaaatgtca cttgtgatga gtgtgccatt   3720

ccaggataac agcttgcacc ctcctcagaa tgttttcagc gaaagagtgg ggtggctgtt   3780

ctctgctcct ggtgctttgg cctcatttca cactattaga attctggggc tgtaaggcca   3840

gccagtgtca gctcatgttc cattggctct ccacctgcca tttttaggga gctattcctt   3900

atatagttac aaattccctt gtcatttact tatttggaaa catgggattt actctgacaa   3960

gctttagcct atgttatggg attcagaaca atgagatcat aataattctc actgaccaaa   4020

gctgggactc catcctgcca tttttgtgtg gagatattca taattctgca atactttaaa   4080

acatttagaa aacaccccag ggtaggtctg tggcccttag acagtgaagt cttaattgtc   4140

aatattattt ttgtctaatt ctgtatatat ataacttatt atattttata atctcaataa   4200

acacattaat aagatt                                                   4216


<210>  8230
<211>  448
<212>  PRT
<213>  Homosapiens

<400>  8230

Met Ala His Val Gly Asp Cys Thr Gln Thr Pro Trp Leu Pro Val Leu 
1               5                   10                  15      


Val Val Ser Leu Met Cys Ser Ala Arg Ala Glu Tyr Ser Asn Cys Gly 
            20                  25                  30          


Glu Asn Glu Tyr Tyr Asn Gln Thr Thr Gly Leu Cys Gln Glu Cys Pro 
        35                  40                  45              


Pro Cys Gly Pro Gly Glu Glu Pro Tyr Leu Ser Cys Gly Tyr Gly Thr 
    50                  55                  60                  


Lys Asp Glu Asp Tyr Gly Cys Val Pro Cys Pro Ala Glu Lys Phe Ser 
65                  70                  75                  80  


Lys Gly Gly Tyr Gln Ile Cys Arg Arg His Lys Asp Cys Glu Gly Phe 
                85                  90                  95      


Phe Arg Ala Thr Val Leu Thr Pro Gly Asp Met Glu Asn Asp Ala Glu 
            100                 105                 110         


Cys Gly Pro Cys Leu Pro Gly Tyr Tyr Met Leu Glu Asn Arg Pro Arg 
        115                 120                 125             


Asn Ile Tyr Gly Met Val Cys Tyr Ser Cys Leu Leu Ala Pro Pro Asn 
    130                 135                 140                 


Thr Lys Glu Cys Val Gly Ala Thr Ser Gly Ala Ser Ala Asn Phe Pro 
145                 150                 155                 160 


Gly Thr Ser Gly Ser Ser Thr Leu Ser Pro Phe Gln His Ala His Lys 
                165                 170                 175     


Glu Leu Ser Gly Gln Gly His Leu Ala Thr Ala Leu Ile Ile Ala Met 
            180                 185                 190         


Ser Thr Ile Phe Ile Met Ala Ile Ala Ile Val Leu Ile Ile Met Phe 
        195                 200                 205             


Tyr Ile Leu Lys Thr Lys Pro Ser Ala Pro Ala Cys Cys Thr Ser His 
    210                 215                 220                 


Pro Gly Lys Ser Val Glu Ala Gln Val Ser Lys Asp Glu Glu Lys Lys 
225                 230                 235                 240 


Glu Ala Pro Asp Asn Val Val Met Phe Ser Glu Lys Asp Glu Phe Glu 
                245                 250                 255     


Lys Leu Thr Ala Thr Pro Ala Lys Pro Thr Lys Ser Glu Asn Asp Ala 
            260                 265                 270         


Ser Ser Glu Asn Glu Gln Leu Leu Ser Arg Ser Val Asp Ser Asp Glu 
        275                 280                 285             


Glu Pro Ala Pro Asp Lys Gln Gly Ser Pro Glu Leu Cys Leu Leu Ser 
    290                 295                 300                 


Leu Val His Leu Ala Arg Glu Lys Ser Ala Thr Ser Asn Lys Ser Ala 
305                 310                 315                 320 


Gly Ile Gln Ser Arg Arg Lys Lys Ile Leu Asp Val Tyr Ala Asn Val 
                325                 330                 335     


Cys Gly Val Val Glu Gly Leu Ser Pro Thr Glu Leu Pro Phe Asp Cys 
            340                 345                 350         


Leu Glu Lys Thr Ser Arg Met Leu Ser Ser Thr Tyr Asn Ser Glu Lys 
        355                 360                 365             


Ala Val Val Lys Thr Trp Arg His Leu Ala Glu Ser Phe Gly Leu Lys 
    370                 375                 380                 


Arg Asp Glu Ile Gly Gly Met Thr Asp Gly Met Gln Leu Phe Asp Arg 
385                 390                 395                 400 


Ile Ser Thr Ala Gly Tyr Ser Ile Pro Glu Leu Leu Thr Lys Leu Val 
                405                 410                 415     


Gln Ile Glu Arg Leu Asp Ala Val Glu Ser Leu Cys Ala Asp Ile Leu 
            420                 425                 430         


Glu Trp Ala Gly Val Val Pro Pro Ala Ser Gln Pro His Ala Ala Ser 
        435                 440                 445             


<210>  8231
<211>  1230
<212>  DNA
<213>  Homosapiens

<400>  8231
atggggcact gggccacaaa actttgctta cccttccatg ctctggcttt tggccgttat     60

ccctgtattt tcctggaaat cagctgtaac cacttcacat ttcaacagct gacgtcgttc    120

tcaaccacag cccagttcag cctggggaat ggtgcccacc gcctttatcc aattcccagg    180

gcttcggagt cgtggagctg cccatgtgtt cagctgaaaa gaggagagga agcacagagg    240

tcacatgagc cagtgggtca cgtgagaggt tcctacggcc agcccggaag tggcggtgtt    300

gcttccgtgg gttccattgg cccaccggca gtcacgtggc tgcccatagc agaaacgtgt    360

gtggggttgc gggggaacaa tgtgaacgcg tgtggagtga cgctactggc tgaaacactt    420

agcaattatt tggggaagcc ggggcgtcgg gaaggagagc gcgaattcac cctcctctgc    480

gcctccgtag gaaaaaattg gagcgggggt tcacgagact gcgccgcggc gggcgctaga    540

gcccctcgca cagcgtcgcc aagggtgcgg cgtggagccg ggcgcctggc gccagggtgc    600

tggtcggcgg gcagcggcgc cagcctccga cccgcgactc cggcgagcca aggctgcgcc    660

gggaggagtc ggcgcgggcc ccggggtgcc cccttcaact ggagcgcctt cccctcctgc    720

cttgcggcgc atccccacac ctacaccgga acgaagctcc ggggctgtca cttctgcgcg    780

cttctcggaa aggagtctga actgggagcg ctccgggggg tcgtcgggga ggatgcccgg    840

gcgtcggctg tgtccccaag ctgctcgccg gcgctggcga ggaaggcagt cgggataacg    900

ccgcccaaac tttccttcgc agcagcgttg gcaggaaacg tccctctctg aggctcacga    960

aaagccgaaa aagactcgga cgcttggagg aggcagggcc aagcctgcgc aggagaggtt   1020

ccccggagcc ctggagatgt cctaggggac caggctaatc gccggcttgc gcccaagcga   1080

agggaagtcc tgcaggcacg gcgcctcctt ccctgagccc cgcagtgacc gtgacctccg   1140

cgcgcacccc cgcgcacgtg ctcgcggccg aggaagagga acggtcctgc tgaatcctct   1200

ggaggacagc gactagcgag caggccaggg                                    1230


<210>  8232
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  8232

Met Gly His Trp Ala Thr Lys Leu Cys Leu Pro Phe His Ala Leu Ala 
1               5                   10                  15      


Phe Gly Arg Tyr Pro Cys Ile Phe Leu Glu Ile Ser Cys Asn His Phe 
            20                  25                  30          


Thr Phe Gln Gln Leu Thr Ser Phe Ser Thr Thr Ala Gln Phe Ser Leu 
        35                  40                  45              


Gly Asn Gly Ala His Arg Leu Tyr Pro Ile Pro Arg Ala Ser Glu Ser 
    50                  55                  60                  


Trp Ser Cys Pro Cys Val Gln Leu Lys Arg Gly Glu Glu Ala Gln Arg 
65                  70                  75                  80  


Ser His Glu Pro Val Gly His Val Arg Gly Ser Tyr Gly Gln Pro Gly 
                85                  90                  95      


Ser Gly Gly Val Ala Ser Val Gly Ser Ile Gly Pro Pro Ala Val Thr 
            100                 105                 110         


Trp Leu Pro Ile Ala Glu Thr Cys Val Gly Leu Arg Gly Asn Asn Val 
        115                 120                 125             


Asn Ala Cys Gly Val Thr Leu Leu Ala Glu Thr Leu Ser Asn Tyr Leu 
    130                 135                 140                 


Gly Lys Pro Gly Arg Arg Glu Gly Glu Arg Glu Phe Thr Leu Leu Cys 
145                 150                 155                 160 


Ala Ser Val Gly Lys Asn Trp Ser Gly Gly Ser Arg Asp Cys Ala Ala 
                165                 170                 175     


Ala Gly Ala Arg Ala Pro Arg Thr Ala Ser Pro Arg Val Arg Arg Gly 
            180                 185                 190         


Ala Gly Arg Leu Ala Pro Gly Cys Trp Ser Ala Gly Ser Gly Ala Ser 
        195                 200                 205             


Leu Arg Pro Ala Thr Pro Ala Ser Gln Gly Cys Ala Gly Arg Ser Arg 
    210                 215                 220                 


Arg Gly Pro Arg Gly Ala Pro Phe Asn Trp Ser Ala Phe Pro Ser Cys 
225                 230                 235                 240 


Leu Ala Ala His Pro His Thr Tyr Thr Gly Thr Lys Leu Arg Gly Cys 
                245                 250                 255     


His Phe Cys Ala Leu Leu Gly Lys Glu Ser Glu Leu Gly Ala Leu Arg 
            260                 265                 270         


Gly Val Val Gly Glu Asp Ala Arg Ala Ser Ala Val Ser Pro Ser Cys 
        275                 280                 285             


Ser Pro Ala Leu Ala Arg Lys Ala Val Gly Ile Thr Pro Pro Lys Leu 
    290                 295                 300                 


Ser Phe Ala Ala Ala Leu Ala Gly Asn Val Pro Leu 
305                 310                 315     


<210>  8233
<211>  3596
<212>  DNA
<213>  Homosapiens

<400>  8233
gggagtcagc cagaccccca tcctgacaag gcttgtggaa ctgctgactc aggatgtcgg     60

ggttcaggct gggtgaccac gtgtggctgg agcctccctc cacccacaag accggcgtgg    120

ccatcggggg catcatcaaa gaggcaaagc caggcaaagt cttggttgaa gatgacgagg    180

gcaaggaaca ctggatccga gcagaggact ttggtgtcct cagtcccatg caccccaact    240

cagtccaggg tgtggacgac atgatccgcc tgggggacct gaacgaggca ggcatggtgc    300

acaacctcct gatccgctac cagcagcaca agatctatac atacacaggc tccatcctgg    360

tggccgtcaa cccgttccag gtgctgccgc tctacaccct ggagcaggta cagctctact    420

acagccgcca tatgggcgag ctgcccccgc atgtctttgc catcgccaac aactgctact    480

tcagcatgaa gaggaacaag agggaccagt gctgcatcat cagcggcgag tctggggctg    540

gcaagacgga gaccaccaag ctcatcctgc agttcctggc caccatcagt ggccagcatt    600

cgtggattga gcagcaggtc ctggaagcca accccatcct ggaggccttt ggaaatgcca    660

agacaatccg caacgacaac tcaagccgct ttgggaagta cattgacatc tactttaacc    720

ccagcggggt gatcgagggc gcgcgcatcg agcaatttct cctggagaag tcccgggtct    780

gccggcaggc tcccgaggag cggaactacc atatcttcta ctgcatgctc atgggggtga    840

gtgctgagga caagcagctg ctgagcctgg gcacgccctc cgagtaccac tacctgacca    900

tggggaactg cacttcctgt gaggggctca acgacgccaa ggactacgcc cacatccgct    960

cggccatgaa gatcctccag ttctccgact ccgagagctg ggacgtcatc aagctgctgg   1020

ctgccattct ccacctgggg aatgtggggt tcatggcttc ggtcttcgag aacctggacg   1080

cctcagacgt gatggagacg cccgcctttc ccaccgtgat gaagttactg gaggtgcagc   1140

accaggagct ccgggactgt ctgatcaagc acaccatcct catccgaggg gaatttgtca   1200

ccaggtccct gaacattgcc caggctgctg accggaggga cgcctttgtc aagggcatct   1260

atgggcacct cttcctgtgg attgtcaaga agatcaatgc cgccatcttc acaccaccag   1320

cccaggaccc caaaaatgtg cggagggcca tcggcctcct ggacatattt ggctttgaaa   1380

atttcgagaa caatagcttc gagcagctct gcatcaactt cgccaacgag cacctgcagc   1440

agttctttgt gcagcacgtg ttcaccatgg agcaagagga gtaccgctcg gagaacatct   1500

cctgggacta tatccactac accgacaatc ggcccaccct ggacctgctg gccctcaagc   1560

ccatgagcat catctccctc ctggacgaag aaagccgctt cccgcagggg acagatctca   1620

ccatgctgca aaagctgaac agcgtccatg ccaacaacaa ggccttccta cagcccaaga   1680

acatccacga tgccagattt ggcattgccc attttgccgg cgaggtgtac taccaagcag   1740

aaggcttcct ggagaagaac cgagacgtgc tgagcacaga tatcctcacc ctggtttact   1800

cctccaaaaa caagtttctg agggagatat tcaacttgga gttagcagag accaagctgg   1860

gccatgggac catccgccag gcaaaggcag gaaaccatct cttcaagtct gcagactcaa   1920

ataaacggcc ctccacctta ggaagccagt tcaaacagtc tctggaccag ctgatgaaaa   1980

tcctgaccaa ctgccagcct tacttcatcc gctgcatcaa acctaatgag tacaagaagc   2040

cgctgctgtt cgaccgggag ctgtgcctgc ggcagctgcg atactcgggc atgatggaga   2100

ccgtgcacat ccgcaagtcg ggcttcccca tccgctacac gttcgaggag ttctcgcaga   2160

ggttcggcgt gttgctgccc aacgccatgc ggatgcagct gcaaggcaag ctccgccaga   2220

tgaccctggg catcactgac gtgtggctgc ggacagacaa agactggaaa gcggggaaga   2280

caaaaatttt cctgagggat catcaggaca ctctgctgga ggtacagaga agccaggtgc   2340

tagacagagc ggcgctcagc atccagaaag tccttcgggg ctacagatac aggaaggagt   2400

tcctgaggca gaggcgggca gctgtgaccc tgcaggcctg gtggagaggc tactgcaaca   2460

ggaggaattt caagctgatc ctcgtgggct ttgagcgcct gcaggctatt gcccggagcc   2520

agccgctggc gaggcagtac caggccatgc ggcagaggac agtccagctg caggccctgt   2580

gcaggggata cctggtgcgc cagcaagtcc aggccaagag gagggcagtg gtggtcattc   2640

aggcccatgc caggggcatg gctgcccggc gcaacttcca gcaaaggaag gccaatgcgc   2700

cgctggtcat cccggccgag gggcagaaaa gccaaggcgc tctccctgcc aagaagcgca   2760

gatccatcta cgacaccgtc actgacacgg agatggtgga gaaggtgttc ggcttcctcc   2820

ctgccatgat tgggggccag gagggccagg cctcgccgca ctttgaggat ctggaatcga   2880

agacccagaa gctgcttgag gttgacctgg acacagtccc catggcggag gagcctgagg   2940

aggatgtgga tggcctggcc gagtacacct tccccaagtt tgctgtgact tacttccaga   3000

aatcagccag ccacacacac atccggcggc ccctccgata cccgttgctt taccacgaag   3060

atgacactga ctgcttggcc gccctggtca tatggaacgt catcctgagg ttcatgggtg   3120

atctcccaga gccagtgctg tatgccagga gcagccagca gggcagctca gtgatgcggc   3180

agatccatga cacgctgggc agggagcacg gtgcccaggt tccacagcac agtagatctg   3240

cacaggcaag tggggggcag cagcgggcag aggagggcga cacctaccag gtggccagcc   3300

agctgaacat tggagaggag gcattggagc ctgatggcct tggtgcagac cggcccatgt   3360

ccaacctgga gaaggtgcac ttcatcgtgg gctacgccat cctgcggccc agcctcagga   3420

tgggctcaga attctccagg aacaagcagg cgctaatgtc tttgttcatg gaggtcccta   3480

actccagagt acaaaagtca agcactagca agaactcaat caacaggctc tattctagta   3540

ccctgggagg tggcaaatgg gcttctggag ctcagcaggc atcagatggg gagtga       3596


<210>  8234
<211>  1180
<212>  PRT
<213>  Homosapiens

<400>  8234

Met Ser Gly Phe Arg Leu Gly Asp His Val Trp Leu Glu Pro Pro Ser 
1               5                   10                  15      


Thr His Lys Thr Gly Val Ala Ile Gly Gly Ile Ile Lys Glu Ala Lys 
            20                  25                  30          


Pro Gly Lys Val Leu Val Glu Asp Asp Glu Gly Lys Glu His Trp Ile 
        35                  40                  45              


Arg Ala Glu Asp Phe Gly Val Leu Ser Pro Met His Pro Asn Ser Val 
    50                  55                  60                  


Gln Gly Val Asp Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Met Val His Asn Leu Leu Ile Arg Tyr Gln Gln His Lys Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Phe Gln Val Leu Pro 
            100                 105                 110         


Leu Tyr Thr Leu Glu Gln Val Gln Leu Tyr Tyr Ser Arg His Met Gly 
        115                 120                 125             


Glu Leu Pro Pro His Val Phe Ala Ile Ala Asn Asn Cys Tyr Phe Ser 
    130                 135                 140                 


Met Lys Arg Asn Lys Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Thr Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Thr Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Asn Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile Tyr Phe Asn Pro Ser 
    210                 215                 220                 


Gly Val Ile Glu Gly Ala Arg Ile Glu Gln Phe Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Pro Glu Glu Arg Asn Tyr His Ile Phe Tyr 
                245                 250                 255     


Cys Met Leu Met Gly Val Ser Ala Glu Asp Lys Gln Leu Leu Ser Leu 
            260                 265                 270         


Gly Thr Pro Ser Glu Tyr His Tyr Leu Thr Met Gly Asn Cys Thr Ser 
        275                 280                 285             


Cys Glu Gly Leu Asn Asp Ala Lys Asp Tyr Ala His Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Ile Leu Gln Phe Ser Asp Ser Glu Ser Trp Asp Val Ile Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Val Gly Phe Met Ala Ser 
                325                 330                 335     


Val Phe Glu Asn Leu Asp Ala Ser Asp Val Met Glu Thr Pro Ala Phe 
            340                 345                 350         


Pro Thr Val Met Lys Leu Leu Glu Val Gln His Gln Glu Leu Arg Asp 
        355                 360                 365             


Cys Leu Ile Lys His Thr Ile Leu Ile Arg Gly Glu Phe Val Thr Arg 
    370                 375                 380                 


Ser Leu Asn Ile Ala Gln Ala Ala Asp Arg Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly His Leu Phe Leu Trp Ile Val Lys Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Phe Thr Pro Pro Ala Gln Asp Pro Lys Asn Val Arg Arg Ala 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Glu Asn Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Gln His Val Phe Thr Met Glu Gln Glu Glu Tyr Arg Ser Glu 
465                 470                 475                 480 


Asn Ile Ser Trp Asp Tyr Ile His Tyr Thr Asp Asn Arg Pro Thr Leu 
                485                 490                 495     


Asp Leu Leu Ala Leu Lys Pro Met Ser Ile Ile Ser Leu Leu Asp Glu 
            500                 505                 510         


Glu Ser Arg Phe Pro Gln Gly Thr Asp Leu Thr Met Leu Gln Lys Leu 
        515                 520                 525             


Asn Ser Val His Ala Asn Asn Lys Ala Phe Leu Gln Pro Lys Asn Ile 
    530                 535                 540                 


His Asp Ala Arg Phe Gly Ile Ala His Phe Ala Gly Glu Val Tyr Tyr 
545                 550                 555                 560 


Gln Ala Glu Gly Phe Leu Glu Lys Asn Arg Asp Val Leu Ser Thr Asp 
                565                 570                 575     


Ile Leu Thr Leu Val Tyr Ser Ser Lys Asn Lys Phe Leu Arg Glu Ile 
            580                 585                 590         


Phe Asn Leu Glu Leu Ala Glu Thr Lys Leu Gly His Gly Thr Ile Arg 
        595                 600                 605             


Gln Ala Lys Ala Gly Asn His Leu Phe Lys Ser Ala Asp Ser Asn Lys 
    610                 615                 620                 


Arg Pro Ser Thr Leu Gly Ser Gln Phe Lys Gln Ser Leu Asp Gln Leu 
625                 630                 635                 640 


Met Lys Ile Leu Thr Asn Cys Gln Pro Tyr Phe Ile Arg Cys Ile Lys 
                645                 650                 655     


Pro Asn Glu Tyr Lys Lys Pro Leu Leu Phe Asp Arg Glu Leu Cys Leu 
            660                 665                 670         


Arg Gln Leu Arg Tyr Ser Gly Met Met Glu Thr Val His Ile Arg Lys 
        675                 680                 685             


Ser Gly Phe Pro Ile Arg Tyr Thr Phe Glu Glu Phe Ser Gln Arg Phe 
    690                 695                 700                 


Gly Val Leu Leu Pro Asn Ala Met Arg Met Gln Leu Gln Gly Lys Leu 
705                 710                 715                 720 


Arg Gln Met Thr Leu Gly Ile Thr Asp Val Trp Leu Arg Thr Asp Lys 
                725                 730                 735     


Asp Trp Lys Ala Gly Lys Thr Lys Ile Phe Leu Arg Asp His Gln Asp 
            740                 745                 750         


Thr Leu Leu Glu Val Gln Arg Ser Gln Val Leu Asp Arg Ala Ala Leu 
        755                 760                 765             


Ser Ile Gln Lys Val Leu Arg Gly Tyr Arg Tyr Arg Lys Glu Phe Leu 
    770                 775                 780                 


Arg Gln Arg Arg Ala Ala Val Thr Leu Gln Ala Trp Trp Arg Gly Tyr 
785                 790                 795                 800 


Cys Asn Arg Arg Asn Phe Lys Leu Ile Leu Val Gly Phe Glu Arg Leu 
                805                 810                 815     


Gln Ala Ile Ala Arg Ser Gln Pro Leu Ala Arg Gln Tyr Gln Ala Met 
            820                 825                 830         


Arg Gln Arg Thr Val Gln Leu Gln Ala Leu Cys Arg Gly Tyr Leu Val 
        835                 840                 845             


Arg Gln Gln Val Gln Ala Lys Arg Arg Ala Val Val Val Ile Gln Ala 
    850                 855                 860                 


His Ala Arg Gly Met Ala Ala Arg Arg Asn Phe Gln Gln Arg Lys Ala 
865                 870                 875                 880 


Asn Ala Pro Leu Val Ile Pro Ala Glu Gly Gln Lys Ser Gln Gly Ala 
                885                 890                 895     


Leu Pro Ala Lys Lys Arg Arg Ser Ile Tyr Asp Thr Val Thr Asp Thr 
            900                 905                 910         


Glu Met Val Glu Lys Val Phe Gly Phe Leu Pro Ala Met Ile Gly Gly 
        915                 920                 925             


Gln Glu Gly Gln Ala Ser Pro His Phe Glu Asp Leu Glu Ser Lys Thr 
    930                 935                 940                 


Gln Lys Leu Leu Glu Val Asp Leu Asp Thr Val Pro Met Ala Glu Glu 
945                 950                 955                 960 


Pro Glu Glu Asp Val Asp Gly Leu Ala Glu Tyr Thr Phe Pro Lys Phe 
                965                 970                 975     


Ala Val Thr Tyr Phe Gln Lys Ser Ala Ser His Thr His Ile Arg Arg 
            980                 985                 990         


Pro Leu Arg Tyr Pro Leu Leu Tyr  His Glu Asp Asp Thr  Asp Cys Leu 
        995                 1000                 1005             


Ala Ala  Leu Val Ile Trp Asn  Val Ile Leu Arg Phe  Met Gly Asp 
    1010                 1015                 1020             


Leu Pro  Glu Pro Val Leu Tyr  Ala Arg Ser Ser Gln  Gln Gly Ser 
    1025                 1030                 1035             


Ser Val  Met Arg Gln Ile His  Asp Thr Leu Gly Arg  Glu His Gly 
    1040                 1045                 1050             


Ala Gln  Val Pro Gln His Ser  Arg Ser Ala Gln Ala  Ser Gly Gly 
    1055                 1060                 1065             


Gln Gln  Arg Ala Glu Glu Gly  Asp Thr Tyr Gln Val  Ala Ser Gln 
    1070                 1075                 1080             


Leu Asn  Ile Gly Glu Glu Ala  Leu Glu Pro Asp Gly  Leu Gly Ala 
    1085                 1090                 1095             


Asp Arg  Pro Met Ser Asn Leu  Glu Lys Val His Phe  Ile Val Gly 
    1100                 1105                 1110             


Tyr Ala  Ile Leu Arg Pro Ser  Leu Arg Met Gly Ser  Glu Phe Ser 
    1115                 1120                 1125             


Arg Asn  Lys Gln Ala Leu Met  Ser Leu Phe Met Glu  Val Pro Asn 
    1130                 1135                 1140             


Ser Arg  Val Gln Lys Ser Ser  Thr Ser Lys Asn Ser  Ile Asn Arg 
    1145                 1150                 1155             


Leu Tyr  Ser Ser Thr Leu Gly  Gly Gly Lys Trp Ala  Ser Gly Ala 
    1160                 1165                 1170             


Gln Gln  Ala Ser Asp Gly Glu  
    1175                 1180 


<210>  8235
<211>  532
<212>  DNA
<213>  Homosapiens

<400>  8235
ggttgtgcag ctgggttcct gggggtccct ggagtttgaa ggggtgcctt aagagccatc     60

tgagggcgcc gctggtcatc ccggccgagg ggcagaaaag ccaaggcgct ctccctgcca    120

agaagcgcag atccatctac gacaccgtca ctgacacgga gatggtggag aaggtgttcg    180

gcttcctccc tgccatgatt gggggccagg agggccaggc ctcgccgcac tttgaggatc    240

tggaatcgaa gacccagaag ctgcttgagg ttgacctgga cacagtcccc atggcggagg    300

agcctgagga ggatgtggat ggcctggccg agtacacctt ccccaagttt gctgtgactt    360

acttccagaa atcagccagc cacacacaca tccggcggcc cctccgatac ccgttgcttt    420

accacgaaga tgacactgac tgcttggtac cagggttcac tggcttctag tggatcaggc    480

cagccccgag cctggggtgt gagctatggc tcggggaaag aaggaagggg cc            532


<210>  8236
<211>  102
<212>  PRT
<213>  Homosapiens

<400>  8236

Met Val Glu Lys Val Phe Gly Phe Leu Pro Ala Met Ile Gly Gly Gln 
1               5                   10                  15      


Glu Gly Gln Ala Ser Pro His Phe Glu Asp Leu Glu Ser Lys Thr Gln 
            20                  25                  30          


Lys Leu Leu Glu Val Asp Leu Asp Thr Val Pro Met Ala Glu Glu Pro 
        35                  40                  45              


Glu Glu Asp Val Asp Gly Leu Ala Glu Tyr Thr Phe Pro Lys Phe Ala 
    50                  55                  60                  


Val Thr Tyr Phe Gln Lys Ser Ala Ser His Thr His Ile Arg Arg Pro 
65                  70                  75                  80  


Leu Arg Tyr Pro Leu Leu Tyr His Glu Asp Asp Thr Asp Cys Leu Val 
                85                  90                  95      


Pro Gly Phe Thr Gly Phe 
            100         


<210>  8237
<211>  3686
<212>  DNA
<213>  Homosapiens

<400>  8237
tcaccgtgag actggggatc ccgcacatct gggagcagat gggctgtgca aagggcgcgg     60

ctgctgagga cagggctgtg gctggagaac ctgctgcttc ctgaagccga gccccaccct    120

aaaggaccga gagcacaggc catgggagag gaatcgagta gggatgcaga gcctggtggc    180

actgtcctga gagaggagga ggctgggcag ggccccggcg ctggagaggt gccctgcata    240

tgggacctct cagaggtgca caagagctgt gtgcccaggt acccctgtct cctctcctcc    300

tccagccccc agcctactct cctaatggtc tgtgtctttc agggatgaga tttactgcca    360

gatctgcaag cagctctcgg agaacttcaa aacaagcagc ctggcccggg gctggatcct    420

gctcagcctc tgcctcggct gcttcccacc ctcagagagg ttcatgaagt atctactgaa    480

cttcatcggc caagggccgg cgacctacgg ccccttctgt gccgagcgcc tgagacgcac    540

ctatgccaat ggggtgcgtg cggagccccc cacctggctg gagctgcagg ctgtcaagtc    600

caagaagcac atccccatcc aagtcatctt ggccactgga gagagcctaa ccgtccccgt    660

ggactcagcc tccacatctc gggaaatgtg catgcacatc gctcacaagc agggcctcag    720

cgaccacctg ggcttctccc tccaggtcgc cgtgtacgac aagttctggt ccctgggcag    780

cgggcgcgac cacatgatgg atgccatcgc ccggtgtgag cagatggccc aggagagggg    840

cgagagccag cgccagtcac cctggcgcat ctacttccgg aaggaattct tcaccccctg    900

gcacgactcc cgggaggacc ctgtcagcac cgagcttatt taccgccaag tcctccgagg    960

agtctggtct ggcgagtaca gcttcgagaa ggaggaagag ctggttgagc tgctggcccg   1020

gcactgctac gtgcagctcg gcgcctcagc agagagcaag gctgtccagg agctgctgcc   1080

cagctgcatc ccccacaagc tgtacaggac caagccccca gacaggtggg cgagcctcgt   1140

cactgccgcc tgcgccaagg ccccatacac tcagaagcaa gtcacaccac tggccgtgcg   1200

agagcaggtg gtggacgccg cccgcctgca gtggccgctg ctcttctccc ggctcttcga   1260

agtcatcaca ctctcaggcc cccgcctgcc caagacgcag ctgatcttgg ctgttaactg   1320

gaaggggctt tgcttcctgg accagcagga gaagatgctg ctggaactct ctttcccaga   1380

ggtcatgggt ctggccacca acagggaggc ccagggcggg cagaggctgc tgctctccac   1440

gatgcatgag gagtacgagt ttgtgtcacc cagcagtgtg gccatcgctg agctggtggc   1500

cctgttcctg gagggcctga aggagaggtc cattttcgcc atggccctgc aggacaggaa   1560

ggccacagat gacaccaccc tcctggcctt caagaagggg gacctgttgg tcctcacaaa   1620

gaagcagggg ctgctggcct ctgagaactg gaccctcggc cagaacgaca ggacaggcaa   1680

gacggggctg gtgcccatgg cctgcctcta caccatcccc acggtcacta agccctcggc   1740

acagctgctg agcttgcttg ccatgtcacc agagaagagg aagctggcgg ctcaggaggg   1800

gcagttcaca gagccacgtc ctgaggagcc acccaaggaa aagctgcaca ccctggagga   1860

gttctcctat gagttcttca gggctccaga gaaggacatg gtgagcatgg ccgtgctgcc   1920

cctggcccgt gcccgtggcc acctgtgggc ctattcctgc gagccgctgc gacagccgct   1980

gctcaagcga gtccacgcca acgtcgacct ctgggacatc gcctgccaga tctttccaca   2040

cccatcctcc ggtacatggg cgactaccct tctcggcagg cctggcccac cctggagctc   2100

accgaccaga tcttcacact ggccctgcag cacccggccc tccaggacga ggtctactgc   2160

cagatcctga agcagctgac gcacaactcc aacaggcaca gcgaagagcg gggctggcag   2220

ctgctgtggc tgtgcacggg cctcttcccg cccagcaagg ggctgctgcc ccatgcccag   2280

aagtttatag acactcggag ggggaagctg ctggcccccg actgcagccg ccgaatccag   2340

aaggtcctga ggacggggcc ccggaagcag cccccgcacc aggtggaggt ggaggccgca   2400

gagcagaacg tctcccgcat ctgccacaag atctacttcc ccaatgacac cagtgagatg   2460

ctggaggtgg ttgccaacac acgggtgcgg gatgtgtgtg acagcattgc caccaggctg   2520

cagctggcct cctgggaggg ctgcagcctc ttcatcaaga tttcagacaa ggtcatcagc   2580

cagaaggagg gagacttctt ctttgattcc ttgagggagg tgtctgactg ggtgaagaag   2640

aacaagcccc agaaagaagg ggcccccgtg acgctcccct accaggtgta cttcatgcgg   2700

aaattgtggc tcaacatatc tccagggaag gatgtgaatg cagacaccat actccattac   2760

caccaggagc tgcccaagta cctgcgcgga ttccacaagt gttcgcggga ggatgccatc   2820

cacctggcgg gcctcatcta caaggcccag ttcaacaacg accggtccca gctggctagt   2880

gtccccaaga tcctgaggga actggtgcct gagaacctca cacgcctgat gtcctcggag   2940

gagtggaaaa agagcatcct tctagcctat gacaagcata aggacaagac agtggaggag   3000

gccaaggtgg ccttcctgaa gtggatctgc cggtggccca ccttcggatc cgccttcttc   3060

gaggtgaagc aaacctcgga gccttcctac ccggacgtca tcctcatcgc catcaaccga   3120

catggggttc tgctcatcca ccccaagacc aaggacctgc tcaccaccta tcccttcacc   3180

aagatctcca gctggagcag cggcagcacc tacttccaca tggcgctggg gagcctgggc   3240

cgtggcagcc gcctgctgtg cgagacctcc ctgggctata agatggatga cctgctgacc   3300

tcatatgtgc agcagctcct gagtgccatg aacaagcagc ggggctccaa ggccccagcc   3360

ctggccagca cctagcagcg gatgctggcg tgtctgctca ggcgcccttc ccgacctcta   3420

gcctggcggc accttcccag gccctctcaa cccagggcct gtccttggcg ggcagccttc   3480

catgctgccc cccatacaaa gcccactcag ccccgcaggc ggccccctct gtcctgggcg   3540

ctgcccaggg aggccaaaag acgggcccag aatggggtcg ggagtctcgg acccccaggc   3600

tattggtgga tgactgactg acaggacacc tcccaacccc accccacccc accagaatgt   3660

tcaataaaaa ctcctggagc aggaga                                        3686


<210>  8238
<211>  568
<212>  PRT
<213>  Homosapiens

<400>  8238

Met Lys Tyr Leu Leu Asn Phe Ile Gly Gln Gly Pro Ala Thr Tyr Gly 
1               5                   10                  15      


Pro Phe Cys Ala Glu Arg Leu Arg Arg Thr Tyr Ala Asn Gly Val Arg 
            20                  25                  30          


Ala Glu Pro Pro Thr Trp Leu Glu Leu Gln Ala Val Lys Ser Lys Lys 
        35                  40                  45              


His Ile Pro Ile Gln Val Ile Leu Ala Thr Gly Glu Ser Leu Thr Val 
    50                  55                  60                  


Pro Val Asp Ser Ala Ser Thr Ser Arg Glu Met Cys Met His Ile Ala 
65                  70                  75                  80  


His Lys Gln Gly Leu Ser Asp His Leu Gly Phe Ser Leu Gln Val Ala 
                85                  90                  95      


Val Tyr Asp Lys Phe Trp Ser Leu Gly Ser Gly Arg Asp His Met Met 
            100                 105                 110         


Asp Ala Ile Ala Arg Cys Glu Gln Met Ala Gln Glu Arg Gly Glu Ser 
        115                 120                 125             


Gln Arg Gln Ser Pro Trp Arg Ile Tyr Phe Arg Lys Glu Phe Phe Thr 
    130                 135                 140                 


Pro Trp His Asp Ser Arg Glu Asp Pro Val Ser Thr Glu Leu Ile Tyr 
145                 150                 155                 160 


Arg Gln Val Leu Arg Gly Val Trp Ser Gly Glu Tyr Ser Phe Glu Lys 
                165                 170                 175     


Glu Glu Glu Leu Val Glu Leu Leu Ala Arg His Cys Tyr Val Gln Leu 
            180                 185                 190         


Gly Ala Ser Ala Glu Ser Lys Ala Val Gln Glu Leu Leu Pro Ser Cys 
        195                 200                 205             


Ile Pro His Lys Leu Tyr Arg Thr Lys Pro Pro Asp Arg Trp Ala Ser 
    210                 215                 220                 


Leu Val Thr Ala Ala Cys Ala Lys Ala Pro Tyr Thr Gln Lys Gln Val 
225                 230                 235                 240 


Thr Pro Leu Ala Val Arg Glu Gln Val Val Asp Ala Ala Arg Leu Gln 
                245                 250                 255     


Trp Pro Leu Leu Phe Ser Arg Leu Phe Glu Val Ile Thr Leu Ser Gly 
            260                 265                 270         


Pro Arg Leu Pro Lys Thr Gln Leu Ile Leu Ala Val Asn Trp Lys Gly 
        275                 280                 285             


Leu Cys Phe Leu Asp Gln Gln Glu Lys Met Leu Leu Glu Leu Ser Phe 
    290                 295                 300                 


Pro Glu Val Met Gly Leu Ala Thr Asn Arg Glu Ala Gln Gly Gly Gln 
305                 310                 315                 320 


Arg Leu Leu Leu Ser Thr Met His Glu Glu Tyr Glu Phe Val Ser Pro 
                325                 330                 335     


Ser Ser Val Ala Ile Ala Glu Leu Val Ala Leu Phe Leu Glu Gly Leu 
            340                 345                 350         


Lys Glu Arg Ser Ile Phe Ala Met Ala Leu Gln Asp Arg Lys Ala Thr 
        355                 360                 365             


Asp Asp Thr Thr Leu Leu Ala Phe Lys Lys Gly Asp Leu Leu Val Leu 
    370                 375                 380                 


Thr Lys Lys Gln Gly Leu Leu Ala Ser Glu Asn Trp Thr Leu Gly Gln 
385                 390                 395                 400 


Asn Asp Arg Thr Gly Lys Thr Gly Leu Val Pro Met Ala Cys Leu Tyr 
                405                 410                 415     


Thr Ile Pro Thr Val Thr Lys Pro Ser Ala Gln Leu Leu Ser Leu Leu 
            420                 425                 430         


Ala Met Ser Pro Glu Lys Arg Lys Leu Ala Ala Gln Glu Gly Gln Phe 
        435                 440                 445             


Thr Glu Pro Arg Pro Glu Glu Pro Pro Lys Glu Lys Leu His Thr Leu 
    450                 455                 460                 


Glu Glu Phe Ser Tyr Glu Phe Phe Arg Ala Pro Glu Lys Asp Met Val 
465                 470                 475                 480 


Ser Met Ala Val Leu Pro Leu Ala Arg Ala Arg Gly His Leu Trp Ala 
                485                 490                 495     


Tyr Ser Cys Glu Pro Leu Arg Gln Pro Leu Leu Lys Arg Val His Ala 
            500                 505                 510         


Asn Val Asp Leu Trp Asp Ile Ala Cys Gln Ile Phe Pro His Pro Ser 
        515                 520                 525             


Ser Gly Thr Trp Ala Thr Thr Leu Leu Gly Arg Pro Gly Pro Pro Trp 
    530                 535                 540                 


Ser Ser Pro Thr Arg Ser Ser His Trp Pro Cys Ser Thr Arg Pro Ser 
545                 550                 555                 560 


Arg Thr Arg Ser Thr Ala Arg Ser 
                565             


<210>  8239
<211>  4394
<212>  DNA
<213>  Homosapiens

<400>  8239
tcaccgtgag actggggatc ccgcacatct gggagcagat gggctgtgca aagggcgcgg     60

ctgctgagga cagggctgtg gctggagaac ctgctgcttc ctgaagccga gccccaccct    120

aaaggaccga gagcacaggc catgggagag gaatcgagta gggatgcaga gcctggtggc    180

actgtcctga gagaggagga ggctgggcag ggccccggcg ctggagaggt gccctgcata    240

tgggacctct cagaggtgca caagagctgt gtgcccaggt acccctgtct cctctcctcc    300

tccagccccc agcctactct cctaatggtc tgtgtctttc agggatgaga tttactgcca    360

gatctgcaag cagctctcgg agaacttcaa aacaagcagc ctggcccggg gctggatcct    420

gctcagcctc tgcctcggct gcttcccacc ctcagagagg ttcatgaagt atctactgaa    480

cttcatcggc caagggccgg cgacctacgg ccccttctgt gccgagcgcc tgagacgcac    540

ctatgccaat ggggtgcgtg cggagccccc cacctggctg gagctgcagg ctgtcaagtc    600

caagaagcac atccccatcc aagtcatctt ggccactgga gagagcctaa ccgtccccgt    660

ggactcagcc tccacatctc gggaaatgtg catgcacatc gctcacaagc agggcctcag    720

cgaccacctg ggcttctccc tccaggtcgc cgtgtacgac aagttctggt ccctgggcag    780

cgggcgcgac cacatgatgg atgccatcgc ccggtgtgag cagatggccc aggagagggg    840

cgagagccag cgccagtcac cctggcgcat ctacttccgg aaggaattct tcaccccctg    900

gcacgactcc cgggaggacc ctgtcagcac cgagcttatt taccgccaag tcctccgagg    960

agtctggtct ggcgagtaca gcttcgagaa ggaggaagag ctggttgagc tgctggcccg   1020

gcactgctac gtgcagctcg gcgcctcagc agagagcaag gctgtccagg agctgctgcc   1080

cagctgcatc ccccacaagc tgtacaggac caagccccca gacaggtggg cgagcctcgt   1140

cactgccgcc tgcgccaagg ccccatacac tcagaagcaa gtcacaccac tggccgtgcg   1200

agagcaggtg gtggacgccg cccgcctgca gtggccgctg ctcttctccc ggctcttcga   1260

agtcatcaca ctctcaggcc cccgcctgcc caagacgcag ctgatcttgg ctgttaactg   1320

gaaggggctt tgcttcctgg accagcagga gaagatgctg ctggaactct ctttcccaga   1380

ggtcatgggt ctggccacca acagggaggc ccagggcggg cagaggctgc tgctctccac   1440

gatgcatgag gagtacgagt ttgtgtcacc cagcagtgtg gccatcgctg agctggtggc   1500

cctgttcctg gagggcctga aggagaggtc cattttcgcc atggccctgc aggacaggaa   1560

ggccacagat gacaccaccc tcctggcctt caagaagggg gacctgttgg tcctcacaaa   1620

gaagcagggg ctgctggcct ctgagaactg gaccctcggc cagaacgaca ggacaggcaa   1680

gacggggctg gtgcccatgg cctgcctcta caccatcccc acggtcacta agccctcggc   1740

acagctgctg agcttgcttg ccatgtcacc agagaagagg aagctggcgg ctcaggaggg   1800

gcagttcaca gagccacgtc ctgaggagcc acccaaggaa aagctgcaca ccctggagga   1860

gttctcctat gagttcttca gggctccaga gaaggacatg gtgagcatgg ccgtgctgcc   1920

cctggcccgt gcccgtggcc acctgtgggc ctattcctgc gagccgctgc gacagccgct   1980

gctcaagcga gtccacgcca acgtcgacct ctgggacatc gcctgccaga tctttccaca   2040

cccatcctcc ggtacatggg cgactaccct tctcggcagg cctggcccac cctggagctc   2100

accgaccaga tcttcacact ggccctgcag cacccggccc tccaggacga ggtctactgc   2160

cagatcctga agcagctgac gcacaactcc aacaggcaca gcgaagagcg gggctggcag   2220

ctgctgtggc tgtgcacggg cctcttcccg cccagcaagg ggctgctgcc ccatgcccag   2280

aagtttatag acactcggag ggggaagctg ctggcccccg actgcagccg ccgaatccag   2340

aaggtcctga ggacggggcc ccggaagcag cccccgcacc aggtggaggt ggaggccgca   2400

gagcagaacg tctcccgcat ctgccacaag atctacttcc ccaatgacac cagtgagatg   2460

ctggaggtgg ttgccaacac acgggtgcgg gatgtgtgtg acagcattgc caccaggctg   2520

cagctggcct cctgggaggg ctgcagcctc ttcatcaaga tttcagacaa ggtgggccgg   2580

gctggggctg ggcagacggt gggcggacgg gcagtgagcg aggccctagg tgctgcctgt   2640

gggggcctca gcctaccagg ggcacccatg ctggaccagg ctgcacggcc agggctgctg   2700

ggacagaggt aggtggggtc ctggagcaga gccagctcca cacgccaata gcccacgcac   2760

agccgactcc agcgcagcac ccaggccgta ggcggccact ggaccagaac ccagcaggtt   2820

ctcaggagga cagtccccgg aagccaccca acttccctgt accttcccct tccccaggtc   2880

atcagccaga aggagggaga cttcttcttt gattccttga gggaggtgtc tgactgggtg   2940

aagaagaaca agccccagaa agaaggggcc cccgtgacgc tcccctacca ggtgtacttc   3000

atgcggaaat tgtggctcaa catatctcca gggaaggatg tgaatgcaga caccatactc   3060

cattaccacc aggagctgcc caagtacctg cgcggattcc acaagtgttc gcgggaggat   3120

gccatccacc tggcgggcct catctacaag gcccagttca acaacgaccg gtcccagctg   3180

gctagtgtcc ccaagatcct gagggaactg gtgcctgaga acctcacacg cctgatgtcc   3240

tcggaggagt ggaaaaagag catccttcta gcctatgaca agcataagga caagacagtg   3300

gaggaggcca aggtggcctt cctgaagtgg atctgccggt ggcccacctt cggatccgcc   3360

ttcttcgagg tgaagcaaac ctcggagcct tcctacccgg acgtcatcct catcgccatc   3420

aaccgacatg gggttctgct catccacccc aagaccaagg acctgctcac cacctatccc   3480

ttcaccaaga tctccagctg gagcagcggc agcacctact tccacatggc gctggggagc   3540

ctgggccgtg gcagccgcct gctgtgcgag acctccctgg tgagctcagg ttctttctcc   3600

catccaagat gcataggaca gagctgctgg agactgggtt ccccaccctc acccctttca   3660

agtggctcac taagagggct cagtcacagg gcccaggcgg ggccagcaga tctggagagg   3720

gcctgggtgc atccccagga ccagcagcca aggtggcaag gccaggcggg accccctgcg   3780

cccttggccc attccaagga gggagggaga cccagctcca gcagggcaag cagaaatgac   3840

ggccccaatg gcaggagccc gccttccctt tctccatgcc ctgcactgct ggttgctgag   3900

gaagagaagg tggtccctga gtccaggacc cccacctgcc ctctgcaccc acagcctctg   3960

acccccccgt cccctgtcca gggctataag atggatgacc tgctgacctc atatgtgcag   4020

cagctcctga gtgccatgaa caagcagcgg ggctccaagg ccccagccct ggccagcacc   4080

tagcagcgga tgctggcgtg tctgctcagg cgcccttccc gacctctagc ctggcggcac   4140

cttcccaggc cctctcaacc cagggcctgt ccttggcggg cagccttcca tgctgccccc   4200

catacaaagc ccactcagcc ccgcaggcgg ccccctctgt cctgggcgct gcccagggag   4260

gccaaaagac gggcccagaa tggggtcggg agtctcggac ccccaggcta ttggtggatg   4320

actgactgac aggacacctc ccaaccccac cccaccccac cagaatgttc aataaaaact   4380

cctggagcag gaga                                                     4394


<210>  8240
<211>  568
<212>  PRT
<213>  Homosapiens

<400>  8240

Met Lys Tyr Leu Leu Asn Phe Ile Gly Gln Gly Pro Ala Thr Tyr Gly 
1               5                   10                  15      


Pro Phe Cys Ala Glu Arg Leu Arg Arg Thr Tyr Ala Asn Gly Val Arg 
            20                  25                  30          


Ala Glu Pro Pro Thr Trp Leu Glu Leu Gln Ala Val Lys Ser Lys Lys 
        35                  40                  45              


His Ile Pro Ile Gln Val Ile Leu Ala Thr Gly Glu Ser Leu Thr Val 
    50                  55                  60                  


Pro Val Asp Ser Ala Ser Thr Ser Arg Glu Met Cys Met His Ile Ala 
65                  70                  75                  80  


His Lys Gln Gly Leu Ser Asp His Leu Gly Phe Ser Leu Gln Val Ala 
                85                  90                  95      


Val Tyr Asp Lys Phe Trp Ser Leu Gly Ser Gly Arg Asp His Met Met 
            100                 105                 110         


Asp Ala Ile Ala Arg Cys Glu Gln Met Ala Gln Glu Arg Gly Glu Ser 
        115                 120                 125             


Gln Arg Gln Ser Pro Trp Arg Ile Tyr Phe Arg Lys Glu Phe Phe Thr 
    130                 135                 140                 


Pro Trp His Asp Ser Arg Glu Asp Pro Val Ser Thr Glu Leu Ile Tyr 
145                 150                 155                 160 


Arg Gln Val Leu Arg Gly Val Trp Ser Gly Glu Tyr Ser Phe Glu Lys 
                165                 170                 175     


Glu Glu Glu Leu Val Glu Leu Leu Ala Arg His Cys Tyr Val Gln Leu 
            180                 185                 190         


Gly Ala Ser Ala Glu Ser Lys Ala Val Gln Glu Leu Leu Pro Ser Cys 
        195                 200                 205             


Ile Pro His Lys Leu Tyr Arg Thr Lys Pro Pro Asp Arg Trp Ala Ser 
    210                 215                 220                 


Leu Val Thr Ala Ala Cys Ala Lys Ala Pro Tyr Thr Gln Lys Gln Val 
225                 230                 235                 240 


Thr Pro Leu Ala Val Arg Glu Gln Val Val Asp Ala Ala Arg Leu Gln 
                245                 250                 255     


Trp Pro Leu Leu Phe Ser Arg Leu Phe Glu Val Ile Thr Leu Ser Gly 
            260                 265                 270         


Pro Arg Leu Pro Lys Thr Gln Leu Ile Leu Ala Val Asn Trp Lys Gly 
        275                 280                 285             


Leu Cys Phe Leu Asp Gln Gln Glu Lys Met Leu Leu Glu Leu Ser Phe 
    290                 295                 300                 


Pro Glu Val Met Gly Leu Ala Thr Asn Arg Glu Ala Gln Gly Gly Gln 
305                 310                 315                 320 


Arg Leu Leu Leu Ser Thr Met His Glu Glu Tyr Glu Phe Val Ser Pro 
                325                 330                 335     


Ser Ser Val Ala Ile Ala Glu Leu Val Ala Leu Phe Leu Glu Gly Leu 
            340                 345                 350         


Lys Glu Arg Ser Ile Phe Ala Met Ala Leu Gln Asp Arg Lys Ala Thr 
        355                 360                 365             


Asp Asp Thr Thr Leu Leu Ala Phe Lys Lys Gly Asp Leu Leu Val Leu 
    370                 375                 380                 


Thr Lys Lys Gln Gly Leu Leu Ala Ser Glu Asn Trp Thr Leu Gly Gln 
385                 390                 395                 400 


Asn Asp Arg Thr Gly Lys Thr Gly Leu Val Pro Met Ala Cys Leu Tyr 
                405                 410                 415     


Thr Ile Pro Thr Val Thr Lys Pro Ser Ala Gln Leu Leu Ser Leu Leu 
            420                 425                 430         


Ala Met Ser Pro Glu Lys Arg Lys Leu Ala Ala Gln Glu Gly Gln Phe 
        435                 440                 445             


Thr Glu Pro Arg Pro Glu Glu Pro Pro Lys Glu Lys Leu His Thr Leu 
    450                 455                 460                 


Glu Glu Phe Ser Tyr Glu Phe Phe Arg Ala Pro Glu Lys Asp Met Val 
465                 470                 475                 480 


Ser Met Ala Val Leu Pro Leu Ala Arg Ala Arg Gly His Leu Trp Ala 
                485                 490                 495     


Tyr Ser Cys Glu Pro Leu Arg Gln Pro Leu Leu Lys Arg Val His Ala 
            500                 505                 510         


Asn Val Asp Leu Trp Asp Ile Ala Cys Gln Ile Phe Pro His Pro Ser 
        515                 520                 525             


Ser Gly Thr Trp Ala Thr Thr Leu Leu Gly Arg Pro Gly Pro Pro Trp 
    530                 535                 540                 


Ser Ser Pro Thr Arg Ser Ser His Trp Pro Cys Ser Thr Arg Pro Ser 
545                 550                 555                 560 


Arg Thr Arg Ser Thr Ala Arg Ser 
                565             


<210>  8241
<211>  4923
<212>  DNA
<213>  Homosapiens

<400>  8241
tcaccgtgag actggggatc ccgcacatct gggagcagat gggctgtgca aagggcgcgg     60

ctgctgagga cagggctgtg gctggagaac ctgctgcttc ctgaagccga gccccaccct    120

aaaggaccga gagcacaggc catgggagag gaatcgagta gggatgcaga gcctggtggc    180

actgtcctga gagaggagga ggctgggcag ggccccggcg ctggagaggt gccctgcata    240

tgggacctct cagaggtgca caagagctgt gtgcccaggt acccctgtct cctctcctcc    300

tccagccccc agcctactct cctaatggtc tgtgtctttc agggatgaga tttactgcca    360

gatctgcaag cagctctcgg agaacttcaa aacaagcagc ctggcccggg gctggatcct    420

gctcagcctc tgcctcggct gcttcccacc ctcagagagg ttcatgaagt atctactgaa    480

cttcatcggc caagggccgg cgacctacgg ccccttctgt gccgagcgcc tgagacgcac    540

ctatgccaat ggggtgcgtg cggagccccc cacctggctg gagctgcagg ctgtcaagtc    600

caagaagcac atccccatcc aagtcatctt ggccactgga gagagcctaa ccgtccccgt    660

ggactcagcc tccacatctc gggaaatgtg catgcacatc gctcacaagc agggcctcag    720

cgaccacctg ggcttctccc tccaggtcgc cgtgtacgac aagttctggt ccctgggcag    780

cgggcgcgac cacatgatgg atgccatcgc ccggtgtgag cagatggccc aggagagggg    840

cgagagccag cgccagtcac cctggcgcat ctacttccgg aaggaattct tcaccccctg    900

gcacgactcc cgggaggacc ctgtcagcac cgagcttatt taccgccaag tcctccgagg    960

agtctggtct ggcgagtaca gcttcgagaa ggaggaagag ctggttgagc tgctggcccg   1020

gcactgctac gtgcagctcg gcgcctcagc agagagcaag gctgtccagg agctgctgcc   1080

cagctgcatc ccccacaagc tgtacaggac caagccccca gacaggtggg cgagcctcgt   1140

cactgccgcc tgcgccaagg ccccatacac tcagaagcaa gtcacaccac tggccgtgcg   1200

agagcaggtg gtggacgccg cccgcctgca gtggccgctg ctcttctccc ggctcttcga   1260

agtcatcaca ctctcaggcc cccgcctgcc caagacgcag ctgatcttgg ctgttaactg   1320

gaaggggctt tgcttcctgg accagcagga gaagatgctg ctggaactct ctttcccaga   1380

ggtcatgggt ctggccacca acagggaggc ccagggcggg cagaggctgc tgctctccac   1440

gatgcatgag gagtacgagt ttgtgtcacc cagcagtgtg gccatcgctg agctggtggc   1500

cctgttcctg gagggcctga aggagaggtc cattttcgcc atggccctgc aggacaggaa   1560

ggccacagat gacaccaccc tcctggcctt caagaagggg gacctgttgg tcctcacaaa   1620

gaagcagggg ctgctggcct ctgagaactg gaccctcggc cagaacgaca ggacaggcaa   1680

gacggggctg gtgcccatgg cctgcctcta caccatcccc acggtcacta agccctcggc   1740

acagctgctg agcttgcttg ccatgtcacc agagaagagg aagctggcgg ctcaggaggg   1800

gcagttcaca gagccacgtc ctgaggagcc acccaaggaa aagctgcaca ccctggagga   1860

gttctcctat gagttcttca gggctccaga gaaggacatg gtgagcatgg ccgtgctgcc   1920

cctggcccgt gcccgtggcc acctgtgggc ctattcctgc gagccgctgc gacagccgct   1980

gctcaagcga gtccacgcca acgtcgacct ctgggacatc gcctgccaga tctttccaca   2040

cccatcctcc ggtacatggg cgactaccct tctcggcagg cctggcccac cctggagctc   2100

accgaccaga tcttcacact ggccctgcag cacccggccc tccaggacga ggtctactgc   2160

cagatcctga agcagctgac gcacaactcc aacaggcaca gcgaagagcg gggctggcag   2220

ctgctgtggc tgtgcacggg cctcttcccg cccagcaagg ggctgctgcc ccatgcccag   2280

aagtttatag acactcggag ggggaagctg ctggcccccg actgcagccg ccgaatccag   2340

aaggtcctga ggacggggcc ccggaagcag cccccgcacc aggtggaggt ggaggccgca   2400

gagcagaacg tctcccgcat ctgccacaag atctacttcc ccaatgacac cagtgagatg   2460

ctggaggtgg ttgccaacac acgggtgcgg gatgtgtgtg acagcattgc caccaggctg   2520

cagctggcct cctgggaggg ctgcagcctc ttcatcaaga tttcagacaa ggtgggccgg   2580

gctggggctg ggcagacggt gggcggacgg gcagtgagcg aggccctagg tgctgcctgt   2640

gggggcctca gcctaccagg ggcacccatg ctggaccagg ctgcacggcc agggctgctg   2700

ggacagaggt aggtggggtc ctggagcaga gccagctcca cacgccaata gcccacgcac   2760

agccgactcc agcgcagcac ccaggccgta ggcggccact ggaccagaac ccagcaggtt   2820

ctcaggagga cagtccccgg aagccaccca acttccctgt accttcccct tccccaggtc   2880

atcagccaga aggagggaga cttcttcttt gattccttga gggaggtgtc tgactgggtg   2940

aagaagaaca agccccagaa agaaggtgag gaggcctctg tggagctggg ggagggcgtg   3000

gctgggtggg tcgagggggc actggcggcc tctgtgcggc ccatgcccat tcatccatcc   3060

attcgttccc gtgtgtccct gggttgtggg aacaaccagg ccctggggcc cggcggtgag   3120

ggccagctca ggcagaaaca ggtggctgca ccttggagtg atgaaggatg ccccagggct   3180

gaggggcatg accctcatgg gctgggagtg cgagtccagg aatgttcctg gagaaggcag   3240

cctctacact aatattgaag gaaaatgtgg ggactgggga ggaagaagcg tgggggcttt   3300

cgaggcaggg aggtggcagg cgcagtgtgg ggggtggcag ggggtcaggg ctggtgtacc   3360

tgctgggaca ggcttggtgc ccactgctgg ccctcgccca ggggcccccg tgacgctccc   3420

ctaccaggtg tacttcatgc ggaaattgtg gctcaacata tctccaggga aggatgtgaa   3480

tgcagacacc atactccatt accaccaggt accgggcagg ctgccctggt gggcactggg   3540

gccaccccca tcttcccaca cctgttctga ggctgtagaa gccagcaggc cagggcaggg   3600

ccagcctcag ccctgggtac cagcccatgt ggtaggcaga ccaagcccct gagggctctg   3660

gaaccaggag cagagggcag caatgtttgg ggacagtgac tgcactggca cctgcagcat   3720

gacttggaga gggtgggaca gagggtcctg tgacccatgg agcagtggcc gtggcctgca   3780

gggccaacca catgggtgga gcaggccatc acctccacgc agatgtcagg gggccctgcc   3840

ctgactcagg gtcattcccc tggcctgaaa ctctctaccc tgctcagtcc gtcctggatg   3900

gagtgggcta agccccagtt ccccaccatc tgagcgggaa agaggttggg ggcgggtggg   3960

ccgcagctgg agacccagca tgcccagtgt gtccatcacc caggagctgc ccaagtacct   4020

gcgcggattc cacaagtgtt cgcgggagga tgccatccac ctggcgggcc tcatctacaa   4080

ggcccagttc aacaacgacc ggtcccagct ggctagtgtc cccaagatcc tgagggaact   4140

ggtgcctgag aacctcacac gcctgatgtc ctcggaggag tggaaaaaga gcatccttct   4200

agcctatgac aagcataagg acaagacagt ggaggaggcc aaggtggcct tcctgaagtg   4260

gatctgccgg tggcccacct tcggatccgc cttcttcgag gtgaagcaaa cctcggagcc   4320

ttcctacccg gacgtcatcc tcatcgccat caaccgacat ggggttctgc tcatccaccc   4380

caagaccaag gacctgctca ccacctatcc cttcaccaag atctccagct ggagcagcgg   4440

cagcacctac ttccacatgg cgctggggag cctgggccgt ggcagccgcc tgctgtgcga   4500

gacctccctg ggctataaga tggatgacct gctgacctca tatgtgcagc agctcctgag   4560

tgccatgaac aagcagcggg gctccaaggc cccagccctg gccagcacct agcagcggat   4620

gctggcgtgt ctgctcaggc gcccttcccg acctctagcc tggcggcacc ttcccaggcc   4680

ctctcaaccc agggcctgtc cttggcgggc agccttccat gctgcccccc atacaaagcc   4740

cactcagccc cgcaggcggc cccctctgtc ctgggcgctg cccagggagg ccaaaagacg   4800

ggcccagaat ggggtcggga gtctcggacc cccaggctat tggtggatga ctgactgaca   4860

ggacacctcc caaccccacc ccaccccacc agaatgttca ataaaaactc ctggagcagg   4920

aga                                                                 4923


<210>  8242
<211>  568
<212>  PRT
<213>  Homosapiens

<400>  8242

Met Lys Tyr Leu Leu Asn Phe Ile Gly Gln Gly Pro Ala Thr Tyr Gly 
1               5                   10                  15      


Pro Phe Cys Ala Glu Arg Leu Arg Arg Thr Tyr Ala Asn Gly Val Arg 
            20                  25                  30          


Ala Glu Pro Pro Thr Trp Leu Glu Leu Gln Ala Val Lys Ser Lys Lys 
        35                  40                  45              


His Ile Pro Ile Gln Val Ile Leu Ala Thr Gly Glu Ser Leu Thr Val 
    50                  55                  60                  


Pro Val Asp Ser Ala Ser Thr Ser Arg Glu Met Cys Met His Ile Ala 
65                  70                  75                  80  


His Lys Gln Gly Leu Ser Asp His Leu Gly Phe Ser Leu Gln Val Ala 
                85                  90                  95      


Val Tyr Asp Lys Phe Trp Ser Leu Gly Ser Gly Arg Asp His Met Met 
            100                 105                 110         


Asp Ala Ile Ala Arg Cys Glu Gln Met Ala Gln Glu Arg Gly Glu Ser 
        115                 120                 125             


Gln Arg Gln Ser Pro Trp Arg Ile Tyr Phe Arg Lys Glu Phe Phe Thr 
    130                 135                 140                 


Pro Trp His Asp Ser Arg Glu Asp Pro Val Ser Thr Glu Leu Ile Tyr 
145                 150                 155                 160 


Arg Gln Val Leu Arg Gly Val Trp Ser Gly Glu Tyr Ser Phe Glu Lys 
                165                 170                 175     


Glu Glu Glu Leu Val Glu Leu Leu Ala Arg His Cys Tyr Val Gln Leu 
            180                 185                 190         


Gly Ala Ser Ala Glu Ser Lys Ala Val Gln Glu Leu Leu Pro Ser Cys 
        195                 200                 205             


Ile Pro His Lys Leu Tyr Arg Thr Lys Pro Pro Asp Arg Trp Ala Ser 
    210                 215                 220                 


Leu Val Thr Ala Ala Cys Ala Lys Ala Pro Tyr Thr Gln Lys Gln Val 
225                 230                 235                 240 


Thr Pro Leu Ala Val Arg Glu Gln Val Val Asp Ala Ala Arg Leu Gln 
                245                 250                 255     


Trp Pro Leu Leu Phe Ser Arg Leu Phe Glu Val Ile Thr Leu Ser Gly 
            260                 265                 270         


Pro Arg Leu Pro Lys Thr Gln Leu Ile Leu Ala Val Asn Trp Lys Gly 
        275                 280                 285             


Leu Cys Phe Leu Asp Gln Gln Glu Lys Met Leu Leu Glu Leu Ser Phe 
    290                 295                 300                 


Pro Glu Val Met Gly Leu Ala Thr Asn Arg Glu Ala Gln Gly Gly Gln 
305                 310                 315                 320 


Arg Leu Leu Leu Ser Thr Met His Glu Glu Tyr Glu Phe Val Ser Pro 
                325                 330                 335     


Ser Ser Val Ala Ile Ala Glu Leu Val Ala Leu Phe Leu Glu Gly Leu 
            340                 345                 350         


Lys Glu Arg Ser Ile Phe Ala Met Ala Leu Gln Asp Arg Lys Ala Thr 
        355                 360                 365             


Asp Asp Thr Thr Leu Leu Ala Phe Lys Lys Gly Asp Leu Leu Val Leu 
    370                 375                 380                 


Thr Lys Lys Gln Gly Leu Leu Ala Ser Glu Asn Trp Thr Leu Gly Gln 
385                 390                 395                 400 


Asn Asp Arg Thr Gly Lys Thr Gly Leu Val Pro Met Ala Cys Leu Tyr 
                405                 410                 415     


Thr Ile Pro Thr Val Thr Lys Pro Ser Ala Gln Leu Leu Ser Leu Leu 
            420                 425                 430         


Ala Met Ser Pro Glu Lys Arg Lys Leu Ala Ala Gln Glu Gly Gln Phe 
        435                 440                 445             


Thr Glu Pro Arg Pro Glu Glu Pro Pro Lys Glu Lys Leu His Thr Leu 
    450                 455                 460                 


Glu Glu Phe Ser Tyr Glu Phe Phe Arg Ala Pro Glu Lys Asp Met Val 
465                 470                 475                 480 


Ser Met Ala Val Leu Pro Leu Ala Arg Ala Arg Gly His Leu Trp Ala 
                485                 490                 495     


Tyr Ser Cys Glu Pro Leu Arg Gln Pro Leu Leu Lys Arg Val His Ala 
            500                 505                 510         


Asn Val Asp Leu Trp Asp Ile Ala Cys Gln Ile Phe Pro His Pro Ser 
        515                 520                 525             


Ser Gly Thr Trp Ala Thr Thr Leu Leu Gly Arg Pro Gly Pro Pro Trp 
    530                 535                 540                 


Ser Ser Pro Thr Arg Ser Ser His Trp Pro Cys Ser Thr Arg Pro Ser 
545                 550                 555                 560 


Arg Thr Arg Ser Thr Ala Arg Ser 
                565             


<210>  8243
<211>  439
<212>  DNA
<213>  Homosapiens

<400>  8243
ggcgtgtgag gttctcaggc accagttccc tcaggatctt ggggacacta gccagctggg     60

accggtcgtt gttgaactgg gccttgtaga tgaggcccgc caggtggatg gcatcctccc    120

gcgaacactt gtggaatccg cgcagggcca tggcgaaaat ggacctctcc ttcaggccct    180

ccaggaacag ggccaccagc tcagcgatgg ccacactgct gggtgacaca aactcgtact    240

cctcatgcat cgtggagagc agcagcctct gcccgccctg ggcctccctg gagatgaagg    300

acagcgtgac caggagcccc ctccaccttc ccctgatcca gcccctaaac agcctcggga    360

ggtggggttg ggggtcctga gtcacagatg aggacacaga gctgctctgc cagggccagg    420

actaggccag acaccactg                                                 439


<210>  8244
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  8244

Met Arg Pro Ala Arg Trp Met Ala Ser Ser Arg Glu His Leu Trp Asn 
1               5                   10                  15      


Pro Arg Arg Ala Met Ala Lys Met Asp Leu Ser Phe Arg Pro Ser Arg 
            20                  25                  30          


Asn Arg Ala Thr Ser Ser Ala Met Ala Thr Leu Leu Gly Asp Thr Asn 
        35                  40                  45              


Ser Tyr Ser Ser Cys Ile Val Glu Ser Ser Ser Leu Cys Pro Pro Trp 
    50                  55                  60                  


Ala Ser Leu Glu Met Lys Asp Ser Val Thr Arg Ser Pro Leu His Leu 
65                  70                  75                  80  


Pro Leu Ile Gln Pro Leu Asn Ser Leu Gly Arg Trp Gly Trp Gly Ser 
                85                  90                  95      


<210>  8245
<211>  1212
<212>  DNA
<213>  Homosapiens

<400>  8245
ctcgcccagg ggcccccgtg acgctcccct accaggtgta cttcatgcgg aaattgtggc     60

tcaacatatc tccagggaag gatgtgaatg cagacaccat actccattac caccaggtac    120

cgggcaggct gccctggtgg gcactggggc cacccccatc ttcccacacc tgttctgagg    180

ctgtagaagc cagcaggcca gggcagggcc agcctcagcc ctgggtacca gcccatgtgg    240

taggcagacc aagcccctga gggctctgga accaggagca gagggcagca atgtttgggg    300

acagtgactg cactggcacc tgcagcatga cttggagagg gtgggacaga gggtcctgtg    360

acccatggag cagtggccgt ggcctgcagg gccaaccaca tgggtggagc aggccatcac    420

ctccacgcag atgtcagggg gccctgccct gactcagggt cattcccctg gcctgaaact    480

ctctaccctg ctcagtccgt cctggatgga gtgggctaag ccccagttcc ccaccatctg    540

agcgggaaag aggttggggg cgggtgggcc gcagctggag acccagcatg cccagtgtgt    600

ccatcaccca ggagctgccc aagtacctgc gcggattcca caagtgttcg cgggaggatg    660

ccatccacct ggcgggcctc atctacaagg cccagttcaa caacgaccgg tcccagctgg    720

ctagtgtccc caagatcctg agggaactgg tgcctgagaa cctcacacgc ctgatgtcct    780

cggaggagtg gaaaaagagc atccttctag cctatgacaa gcataaggac aagacagtgg    840

aggaggccaa ggtggccttc ctgaagtgga tctgccggtg gcccaccttc ggatccgcct    900

tcttcgaggt gaagcaaacc tcggagcctt cctacccgga cgtcatcctc atcgccatca    960

accgacatgg ggttctgctc atccacccca agaccaagga cctgctcacc acctatccct   1020

tcaccaagat ctccagctgg agcagcggca gcacctactt ccacatggcg ctggggagcc   1080

tgggccgtgg cagccgcctg ctgtgcgaga cctccctggt gagctcaggt tctttctccc   1140

atccaagatg cataggacag agctgctgga gactgggttc cccaccctca cccctttcaa   1200

gtggctcact aa                                                       1212


<210>  8246
<211>  207
<212>  PRT
<213>  Homosapiens

<400>  8246

Met Pro Ser Val Ser Ile Thr Gln Glu Leu Pro Lys Tyr Leu Arg Gly 
1               5                   10                  15      


Phe His Lys Cys Ser Arg Glu Asp Ala Ile His Leu Ala Gly Leu Ile 
            20                  25                  30          


Tyr Lys Ala Gln Phe Asn Asn Asp Arg Ser Gln Leu Ala Ser Val Pro 
        35                  40                  45              


Lys Ile Leu Arg Glu Leu Val Pro Glu Asn Leu Thr Arg Leu Met Ser 
    50                  55                  60                  


Ser Glu Glu Trp Lys Lys Ser Ile Leu Leu Ala Tyr Asp Lys His Lys 
65                  70                  75                  80  


Asp Lys Thr Val Glu Glu Ala Lys Val Ala Phe Leu Lys Trp Ile Cys 
                85                  90                  95      


Arg Trp Pro Thr Phe Gly Ser Ala Phe Phe Glu Val Lys Gln Thr Ser 
            100                 105                 110         


Glu Pro Ser Tyr Pro Asp Val Ile Leu Ile Ala Ile Asn Arg His Gly 
        115                 120                 125             


Val Leu Leu Ile His Pro Lys Thr Lys Asp Leu Leu Thr Thr Tyr Pro 
    130                 135                 140                 


Phe Thr Lys Ile Ser Ser Trp Ser Ser Gly Ser Thr Tyr Phe His Met 
145                 150                 155                 160 


Ala Leu Gly Ser Leu Gly Arg Gly Ser Arg Leu Leu Cys Glu Thr Ser 
                165                 170                 175     


Leu Val Ser Ser Gly Ser Phe Ser His Pro Arg Cys Ile Gly Gln Ser 
            180                 185                 190         


Cys Trp Arg Leu Gly Ser Pro Pro Ser Pro Leu Ser Ser Gly Ser 
        195                 200                 205         


<210>  8247
<211>  901
<212>  DNA
<213>  Homosapiens

<400>  8247
ctcattgcct tctcccttcc tgttccctca tctctgcctt ccccatgtct ctcctctcct     60

tggccgtggc ttctgtctgt gaggaggcag gagctgggga gtgggagcct atgaccccac    120

gtctgacagc catgtccacc tgtgcccaca gcttccgccc acagacctcc agggacagga    180

gcaaattgca ccacagctcc ccgcctggcc tggccctccc caggcggctc agtggctcat    240

gctgtcctgt gagagcccct gccccagagc ggccccacta agcgcatgtg gctcctgggc    300

tacccacagc cagggcagcc tgctggagcc acagggccag ggccatgcag atggaggcct    360

ctgggagcca cctccaatcc ctcaccactc actcaaccag tggcacagtg tccttgtgcc    420

cacactgagc cagcaagtcc tgctgtccac acccacaagc tacctggagg gacaggaccc    480

acctccatcc ttcggaaggc cttcctggaa tcccaccttg gcctccgccc tcggttccgc    540

cccgcccctc tccccccgac cttggggctt gtgtcgagcc cttgggtggg gccaggagga    600

ggtgatggcg tcagaggagg tgtggtcaga ggtgacttgt tcccacctcc agggaggacg    660

cttcgtcttc ggccagcgca gacctggtgt ttgtttgttg ggctcacgct tgcacaatga    720

aggcttgttc acacaaccac agcagcctgc gtggtttgtg gcgggggtcg ggggtggagg    780

ggatggcagc agctctggac acgctgctgc tggggcagtt gaacagaggg acagacatag    840

acaggcacga gttcaggggg ccctagcctc tatcccaggc caggctgcca taagcagttg    900

a                                                                    901


<210>  8248
<211>  220
<212>  PRT
<213>  Homosapiens

<400>  8248

Met Leu Ser Cys Glu Ser Pro Cys Pro Arg Ala Ala Pro Leu Ser Ala 
1               5                   10                  15      


Cys Gly Ser Trp Ala Thr His Ser Gln Gly Ser Leu Leu Glu Pro Gln 
            20                  25                  30          


Gly Gln Gly His Ala Asp Gly Gly Leu Trp Glu Pro Pro Pro Ile Pro 
        35                  40                  45              


His His Ser Leu Asn Gln Trp His Ser Val Leu Val Pro Thr Leu Ser 
    50                  55                  60                  


Gln Gln Val Leu Leu Ser Thr Pro Thr Ser Tyr Leu Glu Gly Gln Asp 
65                  70                  75                  80  


Pro Pro Pro Ser Phe Gly Arg Pro Ser Trp Asn Pro Thr Leu Ala Ser 
                85                  90                  95      


Ala Leu Gly Ser Ala Pro Pro Leu Ser Pro Arg Pro Trp Gly Leu Cys 
            100                 105                 110         


Arg Ala Leu Gly Trp Gly Gln Glu Glu Val Met Ala Ser Glu Glu Val 
        115                 120                 125             


Trp Ser Glu Val Thr Cys Ser His Leu Gln Gly Gly Arg Phe Val Phe 
    130                 135                 140                 


Gly Gln Arg Arg Pro Gly Val Cys Leu Leu Gly Ser Arg Leu His Asn 
145                 150                 155                 160 


Glu Gly Leu Phe Thr Gln Pro Gln Gln Pro Ala Trp Phe Val Ala Gly 
                165                 170                 175     


Val Gly Gly Gly Gly Asp Gly Ser Ser Ser Gly His Ala Ala Ala Gly 
            180                 185                 190         


Ala Val Glu Gln Arg Asp Arg His Arg Gln Ala Arg Val Gln Gly Ala 
        195                 200                 205             


Leu Ala Ser Ile Pro Gly Gln Ala Ala Ile Ser Ser 
    210                 215                 220 


<210>  8249
<211>  906
<212>  DNA
<213>  Homosapiens

<400>  8249
cgacatgaag cccgtgtgta agaggtgcta cgagaagttc ccgctggagc tgaagaagcg     60

gctgaagaag ctgtcggagc tgacctcccg caaggcccag cccaaggcca cagacctcaa    120

ctctgcctga aggccctctt gcgcagctgc ctctcggccc ctccgccttc tcccctcctg    180

ctgtccatgc ttggccccct cgtccccatc cacctgtgcc ctccgcatct taccctccct    240

ttctctttcc tcattgcctt ctcccttcct gttccctcat ctctgccttc cccatgtctc    300

tcctctcctt ggccgtggct tctgtctgtg aggaggcagg agctggggag tgggagccta    360

tgaccccacg tctgacagcc atgtccacct gtgcccacag cttccgccca cagacctcca    420

gggacaggag caaattgcac cacagctccc cgcctggcct ggccctcccc aggcggctca    480

gtggctcatg ctgtcctgtg agagcccctg ccccagagcg gccccactaa gcgcatgtgg    540

ctcctgggct acccacatca accagtggca cagtgtcctt gtgcccacac tgagccagca    600

agtcctgctg tccacaccca caagctacct ggagggacag gacccacctc catccttcgg    660

aaggccttcc tggaatccca ccttggcctc cgccctcggt tccgccccgc ccctctcccc    720

ccgaccttgg ggcttgtgtc gagcccttgg gtggggccag gaggaggtga tggcgtcaga    780

ggaggtgtgg tcagaggtga cttgttccca cctccaggga ggacgcttcg tcttcggcca    840

gcgcagacct ggtgtttgtt tgttgggctc acgcttgcac aatgaaggct tgttcacaca    900

accaca                                                               906


<210>  8250
<211>  138
<212>  PRT
<213>  Homosapiens

<400>  8250

Met Leu Ser Cys Glu Ser Pro Cys Pro Arg Ala Ala Pro Leu Ser Ala 
1               5                   10                  15      


Cys Gly Ser Trp Ala Thr His Ile Asn Gln Trp His Ser Val Leu Val 
            20                  25                  30          


Pro Thr Leu Ser Gln Gln Val Leu Leu Ser Thr Pro Thr Ser Tyr Leu 
        35                  40                  45              


Glu Gly Gln Asp Pro Pro Pro Ser Phe Gly Arg Pro Ser Trp Asn Pro 
    50                  55                  60                  


Thr Leu Ala Ser Ala Leu Gly Ser Ala Pro Pro Leu Ser Pro Arg Pro 
65                  70                  75                  80  


Trp Gly Leu Cys Arg Ala Leu Gly Trp Gly Gln Glu Glu Val Met Ala 
                85                  90                  95      


Ser Glu Glu Val Trp Ser Glu Val Thr Cys Ser His Leu Gln Gly Gly 
            100                 105                 110         


Arg Phe Val Phe Gly Gln Arg Arg Pro Gly Val Cys Leu Leu Gly Ser 
        115                 120                 125             


Arg Leu His Asn Glu Gly Leu Phe Thr Gln 
    130                 135             


<210>  8251
<211>  881
<212>  DNA
<213>  Homosapiens

<400>  8251
gaacaagttt gtggagttcg acatgaagcc cgtgtgtaag aggtgctacg agaagttccc     60

gctggagctg aagaagcggc tgaagaagct gtcggagctg acctcccgca aggcccagcc    120

caaggccaca gacctcaact ctgcctgaag gccctcttgc gcagctgcct ctcggcccct    180

ccgccttctc ccctcctgct gtccatgctt ggccccctcg tccccatcca cctgtgccct    240

ccgcatctta ccctcccttt ctctttcctc attgccttct cccttcctgt tccctcatct    300

ctgccttccc catgtctctc ctctccttgg ccgtggcttc tgtctgtgag gaggcaggag    360

ctggggagtg ggagcctatg accccacgtc tgacagccat gtccacctgt gcccacagct    420

tccgcccaca gacctccagg gacaggagca aattgcacca cagctccccg cctggcctgg    480

ccctccccag gcggctcagt ggctcatgct gtcctgtgag agcccctgcc ccagagcggc    540

cccactaagc gcatgtggct cctgggctac ccacagccag ggcagcctgc tggagccaca    600

gggccagggc catgcagatg gaggcctctg ggagccacct ccaatccctc accactcact    660

caaccagtgg cacagtgtcc ttgtgcccac actgagccag caagtcctgc ttgtcgagcc    720

cttgggtggg gccaggagga ggtgatggcg tcagaggagg tgtggtcaga ggtgacttgt    780

tcccacctcc agggaggacg cttcgtcttc ggccagcgca gacctggtgt ttgtttgttg    840

ggctcacgct tgcacaatga aggcttgttc acacaaccac a                        881


<210>  8252
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  8252

Met Trp Leu Leu Gly Tyr Pro Gln Pro Gly Gln Pro Ala Gly Ala Thr 
1               5                   10                  15      


Gly Pro Gly Pro Cys Arg Trp Arg Pro Leu Gly Ala Thr Ser Asn Pro 
            20                  25                  30          


Ser Pro Leu Thr Gln Pro Val Ala Gln Cys Pro Cys Ala His Thr Glu 
        35                  40                  45              


Pro Ala Ser Pro Ala Cys Arg Ala Leu Gly Trp Gly Gln Glu Glu Val 
    50                  55                  60                  


Met Ala Ser Glu Glu Val Trp Ser Glu Val Thr Cys Ser His Leu Gln 
65                  70                  75                  80  


Gly Gly Arg Phe Val Phe Gly Gln Arg Arg Pro Gly Val Cys Leu Leu 
                85                  90                  95      


Gly Ser Arg Leu His Asn Glu Gly Leu Phe Thr Gln 
            100                 105             


<210>  8253
<211>  1295
<212>  DNA
<213>  Homosapiens

<400>  8253
ctgcctgcag ctactctgac agcctgctcg gcccacagct cttcggggac gtctgctaca     60

actgcagcca tgtgattgaa ggcgatggtg aggccctgtg ttccctcccc caccccacct    120

gctctcctgg ggcctgggtg ctgcagctgt gagcccagcc gggcctgcgg cagcctagcc    180

aggcctgctg agtcccacgc ttccctcaca gtggtgtcgg ccctcaacaa ggcctggtgt    240

gtgagctgct tctcctgctc cacctgcaac agcaagctca ccctgaagaa caagtttgtg    300

gagttcgaca tgaagcccgt gtgtaagagg tgctacgaga agttcccgct ggagctgaag    360

aagcggctga agaagctgtc ggagctgacc tcccgcaagg cccagcccaa ggccacagac    420

ctcaactctg cctgaaggcc ctcttgcgca gctgcctctc ggcccctccg ccttctcccc    480

tcctgctgtc catgcttggc cccctcgtcc ccatccacct gtgccctccg catcttaccc    540

tccctttctc tttcctcatt gccttctccc ttcctgttcc ctcatctctg ccttccccat    600

gtctctcctc tccttggccg tggcttctgt ctgtgaggag gcaggagctg gggagtggga    660

gcctatgacc ccacgtctga cagccatgtc cacctgtgcc cacagcttcc gcccacagac    720

ctccagggac aggagcaaat tgcaccacag ctccccgcct ggcctggccc tccccaggcg    780

gctcagtggc tcatgctgtc ctgtgagagc ccctgcccca gagcggcccc actaagcgca    840

tgtggctcct gggctaccca cagccagggc agcctgctgg agccacaggg ccagggccat    900

gcagatggag gcctctggga gccacctcca atccctcacc actcactcaa ccagtggcac    960

agtgtccttg tgcccacact gagccagcaa gtcctgctgt ccacacccac aagctacctg   1020

gagggacagg acccacctcc atccttcgga aggccttcct ggaatcccac cttggcctcc   1080

gccctcggtt ccgccccgcc cctctccccc cgaccttggg gcttgtgtcg agcccttggg   1140

tggggccagg aggaggtgat ggcgtcagag gaggtgtggt cagaggtgac ttgttcccac   1200

ctccagggag gacgcttcgt cttcggccag cgcagacctg gtgtttgttt gttgggctca   1260

cgcttgcaca atgaaggctt gttcacacaa ccaca                              1295


<210>  8254
<211>  116
<212>  PRT
<213>  Homosapiens

<400>  8254

Met Val Arg Pro Cys Val Pro Ser Pro Thr Pro Pro Ala Leu Leu Gly 
1               5                   10                  15      


Pro Gly Cys Cys Ser Cys Glu Pro Ser Arg Ala Cys Gly Ser Leu Ala 
            20                  25                  30          


Arg Pro Ala Glu Ser His Ala Ser Leu Thr Val Val Ser Ala Leu Asn 
        35                  40                  45              


Lys Ala Trp Cys Val Ser Cys Phe Ser Cys Ser Thr Cys Asn Ser Lys 
    50                  55                  60                  


Leu Thr Leu Lys Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys 
65                  70                  75                  80  


Lys Arg Cys Tyr Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys 
                85                  90                  95      


Lys Leu Ser Glu Leu Thr Ser Arg Lys Ala Gln Pro Lys Ala Thr Asp 
            100                 105                 110         


Leu Asn Ser Ala 
        115     


<210>  8255
<211>  967
<212>  DNA
<213>  Homosapiens

<400>  8255
tgcatgatgg ccctgggctg gggtgtgact gcctgcagct actctgacag cctgctcggc     60

ccacagctct tcggggacgt ctgctacaac tgcagccatg tgattgaagg cgatgtggtg    120

tcggccctca acaaggcctg gtgtgtgagc tgcttctcct gctccacctg caacagcaag    180

ctcaccctga agaacaagtt tgtggagttc gacatgaagc ccgtgtgtaa gaggtgctac    240

gagaagttcc cgctggagct gaagaagcgg ctgaagaagc tgtcggagct gacctcccgc    300

aaggcccagc ccaaggccac agacctcaac tctgcctgaa ggccctcttg cgcagctgcc    360

tctcggcccc tccgccttct cccctcctgc tgtccatgct tggccccctc gtccccatcc    420

acctgtgccc tccgcatctt accctccctg cggctcagtg gctcatgctg tcctgtgaga    480

gcccctgccc cagagcggcc ccactaagcg catgtggctc ctgggctacc cacagccagg    540

gcagcctgct ggagccacag ggccagggcc atgcagatgg aggcctctgg gagccacctc    600

caatccctca ccactcactc aaccagtggc acagtgtcct tgtgcccaca ctgagccagc    660

aagtcctgct gtccacaccc acaagctacc tggagggaca ggacccacct ccatccttcg    720

gaaggccttc ctggaatccc accttggcct ccgccctcgg ttccgccccg cccctctccc    780

cccgaccttg gggcttgtgt cgagcccttg ggtggggcca ggaggaggtg atggcgtcag    840

aggaggtgtg gtcagaggtg acttgttccc acctccaggg aggacgcttc gtcttcggcc    900

agcgcagacc tggtgtttgt ttgttgggct cacgcttgca caatgaaggc ttgttcacac    960

aaccaca                                                              967


<210>  8256
<211>  189
<212>  PRT
<213>  Homosapiens

<400>  8256

Met Leu Gly Pro Leu Val Pro Ile His Leu Cys Pro Pro His Leu Thr 
1               5                   10                  15      


Leu Pro Ala Ala Gln Trp Leu Met Leu Ser Cys Glu Ser Pro Cys Pro 
            20                  25                  30          


Arg Ala Ala Pro Leu Ser Ala Cys Gly Ser Trp Ala Thr His Ser Gln 
        35                  40                  45              


Gly Ser Leu Leu Glu Pro Gln Gly Gln Gly His Ala Asp Gly Gly Leu 
    50                  55                  60                  


Trp Glu Pro Pro Pro Ile Pro His His Ser Leu Asn Gln Trp His Ser 
65                  70                  75                  80  


Val Leu Val Pro Thr Leu Ser Gln Gln Val Leu Leu Ser Thr Pro Thr 
                85                  90                  95      


Ser Tyr Leu Glu Gly Gln Asp Pro Pro Pro Ser Phe Gly Arg Pro Ser 
            100                 105                 110         


Trp Asn Pro Thr Leu Ala Ser Ala Leu Gly Ser Ala Pro Pro Leu Ser 
        115                 120                 125             


Pro Arg Pro Trp Gly Leu Cys Arg Ala Leu Gly Trp Gly Gln Glu Glu 
    130                 135                 140                 


Val Met Ala Ser Glu Glu Val Trp Ser Glu Val Thr Cys Ser His Leu 
145                 150                 155                 160 


Gln Gly Gly Arg Phe Val Phe Gly Gln Arg Arg Pro Gly Val Cys Leu 
                165                 170                 175     


Leu Gly Ser Arg Leu His Asn Glu Gly Leu Phe Thr Gln 
            180                 185                 


<210>  8257
<211>  1142
<212>  DNA
<213>  Homosapiens

<400>  8257
gttggagggc caggctggct gcatgatggc cctgggctgg ggtgtgactg cctgcagcta     60

ctctgacagc ctgctcggcc cacagctctt cggggacgtc tgctacaact gcagccatgt    120

gattgaaggc gatggaacaa gtttgtggag ttcgacatga agcccgtgtg taagaggtgc    180

tacgagaagt tcccgctgga gctgaagaag cggctgaaga agctgtcgga gctgacctcc    240

cgcaaggccc agcccaaggc cacagacctc aactctgcct gaaggccctc ttgcgcagct    300

gcctctcggc ccctccgcct tctcccctcc tgctgtccat gcttggcccc ctcgtcccca    360

tccacctgtg ccctccgcat cttaccctcc ctttctcttt cctcattgcc ttctcccttc    420

ctgttccctc atctctgcct tccccatgtc tctcctctcc ttggccgtgg cttctgtctg    480

tgaggaggca ggagctgggg agtgggagcc tatgacccca cgtctgacag ccatgtccac    540

ctgtgcccac agcttccgcc cacagacctc cagggacagg agcaaattgc accacagctc    600

cccgcctggc ctggccctcc ccaggcggct cagtggctca tgctgtcctg tgagagcccc    660

tgccccagag cggccccact aagcgcatgt ggctcctggg ctacccacag ccagggcagc    720

ctgctggagc cacagggcca gggccatgca gatggaggcc tctgggagcc acctccaatc    780

cctcaccact cactcaacca gtggcacagt gtccttgtgc ccacactgag ccagcaagtc    840

ctgctgtcca cacccacaag ctacctggag ggacaggacc cacctccatc cttcggaagg    900

ccttcctgga atcccacctt ggcctccgcc ctcggttccg ccccgcccct ctccccccga    960

ccttggggct tgtgtcgagc ccttgggtgg ggccaggagg aggtgatggc gtcagaggag   1020

gtgtggtcag aggtgacttg ttcccacctc cagggaggac gcttcgtctt cggccagcgc   1080

agacctggtg tttgtttgtt gggctcacgc ttgcacaatg aaggcttgtt cacacaacca   1140

ca                                                                  1142


<210>  8258
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  8258

Met Met Ala Leu Gly Trp Gly Val Thr Ala Cys Ser Tyr Ser Asp Ser 
1               5                   10                  15      


Leu Leu Gly Pro Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser His 
            20                  25                  30          


Val Ile Glu Gly Asp Gly Thr Ser Leu Trp Ser Ser Thr 
        35                  40                  45  


<210>  8259
<211>  1805
<212>  DNA
<213>  Homosapiens

<400>  8259
ctggccagcg ctgtgtccgg aagctgtgcc ttgggtggcg gcttgggtgg gaggccatgc     60

ggtcctgccc tgatgcaggc cccagccccc agccctcatc ctcacatgca gatccctggg    120

ggaatgcaag gtgctgctca gtgatcccag gcttgcaggg ggtgcctgca ggaggcccca    180

cgtggacagg cagggccgcc tctgcctatg agggcccacc atgccgcagc accaggctgg    240

cacctgactc ctggggctga ggctgccgag ggggaggcca gactgggagg ggatggtgac    300

tcacaaggtt accatcagtg ccttagagga ggggtagggt ctgctgaccc cagggcattc    360

acagaggtgt cagtcccctc tgcccagtgt gaatcctgaa aggcctgcac ctgcccagac    420

tctgctttct gtccccttct gtcactgctg cctcctgggg ccactgtggt cccctggagt    480

cactggctcc tggggtcact gttgtccccg ggtcaccact gtccctcggg gtcaccgctc    540

tagccctgat gccacccggc ccgccctttg tccttgcagc actttgtctg tgccaagtgt    600

gagaagccat tcctggggca ccggcactat gagaagaagg gcctggccta ctgcgagact    660

cactacaacc agctcttcgg ggacgtctgc tacaactgca gccatgtgat tgaaggcgat    720

gtggtgtcgg ccctcaacaa ggcctggtgt gtgagctgct tctcctgctc cacctgcaac    780

agcaagctca ccctgaagaa caagtttgtg gagttcgaca tgaagcccgt gtgtaagagg    840

tgctacgaga agttcccgct ggagctgaag aagcggctga agaagctgtc ggagctgacc    900

tcccgcaagg cccagcccaa ggccacagac ctcaactctg cctgaaggcc ctcttgcgca    960

gctgcctctc ggcccctccg ccttctcccc tcctgctgtc catgcttggc cccctcgtcc   1020

ccatccacct gtgccctccg catcttaccc tccctttctc tttcctcatt gccttctccc   1080

ttcctgttcc ctcatctctg ccttccccat gtctctcctc tccttggccg tggcttctgt   1140

ctgtgaggag gcaggagctg gggagtggga gcctatgacc ccacgtctga cagccatgtc   1200

cacctgtgcc cacagcttcc gcccacagac ctccagggac aggagcaaat tgcaccacag   1260

ctccccgcct ggcctggccc tccccaggcg gctcagtggc tcatgctgtc ctgtgagagc   1320

ccctgcccca gagcggcccc actaagcgca tgtggctcct gggctaccca cagccagggc   1380

agcctgctgg agccacaggg ccagggccat gcagatggag gcctctggga gccacctcca   1440

atccctcacc actcactcaa ccagtggcac agtgtccttg tgcccacact gagccagcaa   1500

gtcctgctgt ccacacccac aagctacctg gagggacagg acccacctcc atccttcgga   1560

aggccttcct ggaatcccac cttggcctcc gccctcggtt ccgccccgcc cctctccccc   1620

cgaccttggg gcttgtgtcg agcccttggg tggggccagg aggaggtgat ggcgtcagag   1680

gaggtgtggt cagaggtgac ttgttcccac ctccagggag gacgcttcgt cttcggccag   1740

cgcagacctg gtgtttgttt gttgggctca cgcttgcaca atgaaggctt gttcacacaa   1800

ccaca                                                               1805


<210>  8260
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  8260

Met Leu Ser Cys Glu Ser Pro Cys Pro Arg Ala Ala Pro Leu Ser Ala 
1               5                   10                  15      


Cys Gly Ser Trp Ala Thr His Ser Gln Gly Ser Leu Leu Glu Pro Gln 
            20                  25                  30          


Gly Gln Gly His Ala Asp Gly Gly Leu Trp Glu Pro Pro Pro Ile Pro 
        35                  40                  45              


His His Ser Leu Asn Gln Trp His Ser Val Leu Val Pro Thr Leu Ser 
    50                  55                  60                  


Gln Gln Val Leu Leu Ser Thr Pro Thr Ser Tyr Leu Glu Gly Gln Asp 
65                  70                  75                  80  


Pro Pro Pro Ser Phe Gly Arg Pro Ser Trp Asn Pro Thr Leu Ala Ser 
                85                  90                  95      


Ala Leu Gly Ser Ala Pro Pro Leu Ser Pro Arg Pro Trp Gly Leu Cys 
            100                 105                 110         


Arg Ala Leu Gly Trp Gly Gln Glu Glu Val Met Ala Ser Glu Glu Val 
        115                 120                 125             


Trp Ser Glu Val Thr Cys Ser His Leu Gln Gly Gly Arg Phe Val Phe 
    130                 135                 140                 


Gly Gln Arg Arg Pro Gly Val Cys Leu Leu Gly Ser Arg Leu His Asn 
145                 150                 155                 160 


Glu Gly Leu Phe Thr Gln 
                165     


<210>  8261
<211>  1388
<212>  DNA
<213>  Homosapiens

<400>  8261
ctgccctgcc atgacaagat gggcgtcccc atctgcgggg cctgccgccg gcccatcgag     60

ggccgagtgg tcaacgcgct gggcaagcag tggcacgtgg aggtgagcca ggctggtgga    120

cacgtggcct caggttgggg ggtgccccag ctcagggtca tgcactttgt ctgtgccaag    180

tgtgagaagc cattcctggg gcaccggcac tatgagaaga agggcctggc ctactgcgag    240

actcactaca accagctctt cggggacgtc tgctacaact gcagccatgt gattgaaggc    300

gatgtggtgt cggccctcaa caaggcctgg tgtgtgagct gcttctcctg ctccacctgc    360

aacagcaagc tcaccctgaa gaacaagttt gtggagttcg acatgaagcc cgtgtgtaag    420

aggtgctacg agaagttccc gctggagctg aagaagcggc tgaagaagct gtcggagctg    480

acctcccgca aggcccagcc caaggccaca gacctcaact ctgcctgaag gccctcttgc    540

gcagctgcct ctcggcccct ccgccttctc ccctcctgct gtccatgctt ggccccctcg    600

tccccatcca cctgtgccct ccgcatctta ccctcccttt ctctttcctc attgccttct    660

cccttcctgt tccctcatct ctgccttccc catgtctctc ctctccttgg ccgtggcttc    720

tgtctgtgag gaggcaggag ctggggagtg ggagcctatg accccacgtc tgacagccat    780

gtccacctgt gcccacagct tccgcccaca gacctccagg gacaggagca aattgcacca    840

cagctccccg cctggcctgg ccctccccag gcggctcagt ggctcatgct gtcctgtgag    900

agcccctgcc ccagagcggc cccactaagc gcatgtggct cctgggctac ccacagccag    960

ggcagcctgc tggagccaca gggccagggc catgcagatg gaggcctctg ggagccacct   1020

ccaatccctc accactcact caaccagtgg cacagtgtcc ttgtgcccac actgagccag   1080

caagtcctgc tgtccacacc cacaagctac ctggagggac aggacccacc tccatccttc   1140

ggaaggcctt cctggaatcc caccttggcc tccgccctcg gttccgcccc gcccctctcc   1200

ccccgacctt ggggcttgtg tcgagccctt gggtggggcc aggaggaggt gatggcgtca   1260

gaggaggtgt ggtcagaggt gacttgttcc cacctccagg gaggacgctt cgtcttcggc   1320

cagcgcagac ctggtgtttg tttgttgggc tcacgcttgc acaatgaagg cttgttcaca   1380

caaccaca                                                            1388


<210>  8262
<211>  169
<212>  PRT
<213>  Homosapiens

<400>  8262

Met Gly Val Pro Ile Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg 
1               5                   10                  15      


Val Val Asn Ala Leu Gly Lys Gln Trp His Val Glu Val Ser Gln Ala 
            20                  25                  30          


Gly Gly His Val Ala Ser Gly Trp Gly Val Pro Gln Leu Arg Val Met 
        35                  40                  45              


His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe Leu Gly His Arg His 
    50                  55                  60                  


Tyr Glu Lys Lys Gly Leu Ala Tyr Cys Glu Thr His Tyr Asn Gln Leu 
65                  70                  75                  80  


Phe Gly Asp Val Cys Tyr Asn Cys Ser His Val Ile Glu Gly Asp Val 
                85                  90                  95      


Val Ser Ala Leu Asn Lys Ala Trp Cys Val Ser Cys Phe Ser Cys Ser 
            100                 105                 110         


Thr Cys Asn Ser Lys Leu Thr Leu Lys Asn Lys Phe Val Glu Phe Asp 
        115                 120                 125             


Met Lys Pro Val Cys Lys Arg Cys Tyr Glu Lys Phe Pro Leu Glu Leu 
    130                 135                 140                 


Lys Lys Arg Leu Lys Lys Leu Ser Glu Leu Thr Ser Arg Lys Ala Gln 
145                 150                 155                 160 


Pro Lys Ala Thr Asp Leu Asn Ser Ala 
                165                 


<210>  8263
<211>  1469
<212>  DNA
<213>  Homosapiens

<400>  8263
ctcggggagc cgtgccctgg ggtggaggcg ctgctggcat gaccctgcag aagggcaggg     60

gtggcacctg ggggctgcac gctgtcttcc aggaaggagc tgacagccga ggcccgcgag    120

ctgaagggtg agctctactg cctgccctgc catgacaaga tgggcgtccc catctgcggg    180

gcctgccgcc ggcccatcga gggccgagtg gtcaacgcgc tgggcaagca gtggcacgtg    240

gagcactttg tctgtgccaa gtgtgagaag ccattcctgg ggcaccggca ctatgagaag    300

aagggcctgg cctactgcga gactcactac aaccagctct tcggggacgt ctgctacaac    360

tgcagccatg tgattgaagg cgatgtggtg tcggccctca acaaggcctg gtgtgtgagc    420

tgcttctcct gctccacctg caacagcaag ctcaccctga agaacaagtt tgtggagttc    480

gacatgaagc ccgtgtgtaa gaggtgctac gagaagttcc cgctggagct gaagaagcgg    540

ctgaagaagc tgtcggagct gacctcccgc aaggcccagc ccaaggccac agacctcaac    600

tctgcctgaa ggccctcttg cgcagctgcc tctcggcccc tccgccttct cccctcctgc    660

tgtccatgct tggccccctc gtccccatcc acctgtgccc tccgcatctt accctccctt    720

tctctttcct cattgccttc tcccttcctg ttccctcatc tctgccttcc ccatgtctct    780

cctctccttg gccgtggctt ctgtctgtga ggaggcagga gctggggagt gggagcctat    840

gaccccacgt ctgacagcca tgtccacctg tgcccacagc ttccgcccac agacctccag    900

ggacaggagc aaattgcacc acagctcccc gcctggcctg gccctcccca ggcggctcag    960

tggctcatgc tgtcctgtga gagcccctgc cccagagcgg ccccactaag cgcatgtggc   1020

tcctgggcta cccacagcca gggcagcctg ctggagccac agggccaggg ccatgcagat   1080

ggaggcctct gggagccacc tccaatccct caccactcac tcaaccagtg gcacagtgtc   1140

cttgtgccca cactgagcca gcaagtcctg ctgtccacac ccacaagcta cctggaggga   1200

caggacccac ctccatcctt cggaaggcct tcctggaatc ccaccttggc ctccgccctc   1260

ggttccgccc cgcccctctc cccccgacct tggggcttgt gtcgagccct tgggtggggc   1320

caggaggagg tgatggcgtc agaggaggtg tggtcagagg tgacttgttc ccacctccag   1380

ggaggacgct tcgtcttcgg ccagcgcaga cctggtgttt gtttgttggg ctcacgcttg   1440

cacaatgaag gcttgttcac acaaccaca                                     1469


<210>  8264
<211>  149
<212>  PRT
<213>  Homosapiens

<400>  8264

Met Gly Val Pro Ile Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg 
1               5                   10                  15      


Val Val Asn Ala Leu Gly Lys Gln Trp His Val Glu His Phe Val Cys 
            20                  25                  30          


Ala Lys Cys Glu Lys Pro Phe Leu Gly His Arg His Tyr Glu Lys Lys 
        35                  40                  45              


Gly Leu Ala Tyr Cys Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val 
    50                  55                  60                  


Cys Tyr Asn Cys Ser His Val Ile Glu Gly Asp Val Val Ser Ala Leu 
65                  70                  75                  80  


Asn Lys Ala Trp Cys Val Ser Cys Phe Ser Cys Ser Thr Cys Asn Ser 
                85                  90                  95      


Lys Leu Thr Leu Lys Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val 
            100                 105                 110         


Cys Lys Arg Cys Tyr Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu 
        115                 120                 125             


Lys Lys Leu Ser Glu Leu Thr Ser Arg Lys Ala Gln Pro Lys Ala Thr 
    130                 135                 140                 


Asp Leu Asn Ser Ala 
145                 


<210>  8265
<211>  2106
<212>  DNA
<213>  Homosapiens

<400>  8265
caaagtgccc agagatcaga aggcgctgcc gcctcggctc tgcagggaca gaatgggccc     60

ctcggggagc cgtgccctgg ggtggaggcg ctgctggcat gaccctgcag aagggcaggg    120

gtggcacctg ggggctgcac gctgtcttcc aggaaggagc tgacagccga ggcccgcgag    180

ctgaagggtg agctctactg cctgccctgc catgacaaga tgggcgtccc catctgcggg    240

gcctgccgcc ggcccatcga gggccgagtg gtcaacgcgc tgggcaagca gtggcacgtg    300

gagcactttg tctgtgccaa gtgtgagaag ccattcctgg ggcaccggca ctatgagaag    360

aagggcctgg cctactgcga gactcactac aaccaggtga gcccggtgca gaaccttcag    420

ggatgcgggt ctggaggggt ggccaggaga gctgccgtga gcaagggagg ctgtgggcac    480

cccctcagga gctctgccag gtgctgagcc caggcctgca ccctcagccc tggctcctgg    540

cctggggtct cgagacctgg gcagctctct tcagtctcag tgtcttcctt tgaagaatgt    600

tctggggctg gtgtgaggtc ccgggcacat ggggctgaca gtgccagcaa ccccctccct    660

cccttgctct ggtacagaag gcagggggcg ctggtgggat gcagtcacca cctgggccca    720

cctccttgca ggacagcagt ggccagagca gaggggcctt ctggggagca acgccccagc    780

ctgttgtcct tcccggaagg gtggttctca tgggttgccg tgccctcaac ccagccttgc    840

agctgggccc tgggaggcag ggcctgggag atgcctgaga ggggccgtgt tggagggcca    900

ggctggctgc atgatggccc tgggctgggg tgtgactgcc tgcagctact ctgacagcct    960

gctcggccca cagctcttcg gggacgtctg ctacaactgc agccatgtga ttgaaggcga   1020

tgtggtgtcg gccctcaaca aggcctggtg tgtgagctgc ttctcctgct ccacctgcaa   1080

cagcaagctc accctgaaga acaagtttgt ggagttcgac atgaagcccg tgtgtaagag   1140

gtgctacgag aagttcccgc tggagctgaa gaagcggctg aagaagctgt cggagctgac   1200

ctcccgcaag gcccagccca aggccacaga cctcaactct gcctgaaggc cctcttgcgc   1260

agctgcctct cggcccctcc gccttctccc ctcctgctgt ccatgcttgg ccccctcgtc   1320

cccatccacc tgtgccctcc gcatcttacc ctccctttct ctttcctcat tgccttctcc   1380

cttcctgttc cctcatctct gccttcccca tgtctctcct ctccttggcc gtggcttctg   1440

tctgtgagga ggcaggagct ggggagtggg agcctatgac cccacgtctg acagccatgt   1500

ccacctgtgc ccacagcttc cgcccacaga cctccaggga caggagcaaa ttgcaccaca   1560

gctccccgcc tggcctggcc ctccccaggc ggctcagtgg ctcatgctgt cctgtgagag   1620

cccctgcccc agagcggccc cactaagcgc atgtggctcc tgggctaccc acagccaggg   1680

cagcctgctg gagccacagg gccagggcca tgcagatgga ggcctctggg agccacctcc   1740

aatccctcac cactcactca accagtggca cagtgtcctt gtgcccacac tgagccagca   1800

agtcctgctg tccacaccca caagctacct ggagggacag gacccacctc catccttcgg   1860

aaggccttcc tggaatccca ccttggcctc cgccctcggt tccgccccgc ccctctcccc   1920

ccgaccttgg ggcttgtgtc gagcccttgg gtggggccag gaggaggtga tggcgtcaga   1980

ggaggtgtgg tcagaggtga cttgttccca cctccaggga ggacgcttcg tcttcggcca   2040

gcgcagacct ggtgtttgtt tgttgggctc acgcttgcac aatgaaggct tgttcacaca   2100

accaca                                                              2106


<210>  8266
<211>  205
<212>  PRT
<213>  Homosapiens

<400>  8266

Met Gly Leu Thr Val Pro Ala Thr Pro Ser Leu Pro Cys Ser Gly Thr 
1               5                   10                  15      


Glu Gly Arg Gly Arg Trp Trp Asp Ala Val Thr Thr Trp Ala His Leu 
            20                  25                  30          


Leu Ala Gly Gln Gln Trp Pro Glu Gln Arg Gly Leu Leu Gly Ser Asn 
        35                  40                  45              


Ala Pro Ala Cys Cys Pro Ser Arg Lys Gly Gly Ser His Gly Leu Pro 
    50                  55                  60                  


Cys Pro Gln Pro Ser Leu Ala Ala Gly Pro Trp Glu Ala Gly Pro Gly 
65                  70                  75                  80  


Arg Cys Leu Arg Gly Ala Val Leu Glu Gly Gln Ala Gly Cys Met Met 
                85                  90                  95      


Ala Leu Gly Trp Gly Val Thr Ala Cys Ser Tyr Ser Asp Ser Leu Leu 
            100                 105                 110         


Gly Pro Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser His Val Ile 
        115                 120                 125             


Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Ser Cys 
    130                 135                 140                 


Phe Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys Asn Lys Phe 
145                 150                 155                 160 


Val Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr Glu Lys Phe 
                165                 170                 175     


Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu Leu Thr Ser 
            180                 185                 190         


Arg Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
        195                 200                 205 


<210>  8267
<211>  2406
<212>  DNA
<213>  Homosapiens

<400>  8267
cagcctgtca gaggggccaa cactgggcgt cgggcagccg tggaggctcg tgaggagtgg     60

agagggcccc tggggctggg gggcctggga agggaggcct ggatgcagca ggagcaccag    120

agagagattc gggtggcagg tggagacggg ggccagggag gttggattgg ggcctttgtg    180

tatctttgcc tggggactct gaatctagat tcctgccacc tttgaggtcc aaggaaacag    240

aaaccatgtt gatttgtctc tccgttgaga acacagctgt cgtccaacac agcgagtagc    300

atcagaaatt attctgaggt cttcacaaaa agactctgta gtgacagttc ctgggtttgg    360

gggcctccat ctgacatagc agtgcttgtc tttggagaca gaaatcgcct gtacgtgttt    420

gggcccttct tcatctggca aaccccgaag gaagggggtg agtgggcctc ccgggacact    480

cactggccac tctgctgggc acagtgacac tcattataac tcgtgtgtgt taaatacatt    540

gggaaaataa tgctttcagc agatatcaat taaatgtcta ctgtattctg cagcatgccc    600

caggcttaga gaaagtagaa agaggaaaat accatccaga gacagtaacc tcgagcattc    660

tggcatcttt cctgctgagc atgcgtccca ttcccaggac acacttgtga ccttctgggc    720

cttgtgacag ggcagtctgc tttcccatac cctgggctga gcccctttga agcccccagc    780

tgctcagtga agttgcaggg gtctggcctc tcttctcctg gaggtggcca ggctgtgtgg    840

gagtgggggc tctgccccta atgcccccgc ctcccgcagg catctctgcc ggccttgcca    900

caaccgtgag aaggccaagg gcctgggcaa gtacatctgc cagcggtgcc acctggtcat    960

cgacgagcag cccctcatgt tcaggagcga cgcctaccac cctgaccact tcaactgcac   1020

ccactgtggg aaggagctga cagccgaggc ccgcgagctg aagggtgagc tctactgcct   1080

gccctgccat gacaagatgg gcgtccccat ctgcggggcc tgccgccggc ccatcgaggg   1140

ccgagtggtc aacgcgctgg gcaagcagtg gcacgtggag cactttgtct gtgccaagtg   1200

tgagaagcca ttcctggggc accggcacta tgagaagaag ggcctggcct actgcgagac   1260

tcactacaac cagctcttcg gggacgtctg ctacaactgc agccatgtga ttgaaggcga   1320

tgtggtgtcg gccctcaaca aggcctggtg tgtgagctgc ttctcctgct ccacctgcaa   1380

cagcaagctc accctgaaga acaagtttgt ggagttcgac atgaagcccg tgtgtaagag   1440

gtgctacgag aagttcccgc tggagctgaa gaagcggctg aagaagctgt cggagctgac   1500

ctcccgcaag gcccagccca aggccacaga cctcaactct gcctgaaggc cctcttgcgc   1560

agctgcctct cggcccctcc gccttctccc ctcctgctgt ccatgcttgg ccccctcgtc   1620

cccatccacc tgtgccctcc gcatcttacc ctccctttct ctttcctcat tgccttctcc   1680

cttcctgttc cctcatctct gccttcccca tgtctctcct ctccttggcc gtggcttctg   1740

tctgtgagga ggcaggagct ggggagtggg agcctatgac cccacgtctg acagccatgt   1800

ccacctgtgc ccacagcttc cgcccacaga cctccaggga caggagcaaa ttgcaccaca   1860

gctccccgcc tggcctggcc ctccccaggc ggctcagtgg ctcatgctgt cctgtgagag   1920

cccctgcccc agagcggccc cactaagcgc atgtggctcc tgggctaccc acagccaggg   1980

cagcctgctg gagccacagg gccagggcca tgcagatgga ggcctctggg agccacctcc   2040

aatccctcac cactcactca accagtggca cagtgtcctt gtgcccacac tgagccagca   2100

agtcctgctg tccacaccca caagctacct ggagggacag gacccacctc catccttcgg   2160

aaggccttcc tggaatccca ccttggcctc cgccctcggt tccgccccgc ccctctcccc   2220

ccgaccttgg ggcttgtgtc gagcccttgg gtggggccag gaggaggtga tggcgtcaga   2280

ggaggtgtgg tcagaggtga cttgttccca cctccaggga ggacgcttcg tcttcggcca   2340

gcgcagacct ggtgtttgtt tgttgggctc acgcttgcac aatgaaggct tgttcacaca   2400

accaca                                                              2406


<210>  8268
<211>  189
<212>  PRT
<213>  Homosapiens

<400>  8268

Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn Cys Thr His 
1               5                   10                  15      


Cys Gly Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys Gly Glu Leu 
            20                  25                  30          


Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile Cys Gly Ala 
        35                  40                  45              


Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu Gly Lys Gln 
    50                  55                  60                  


Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe Leu 
65                  70                  75                  80  


Gly His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys Glu Thr His 
                85                  90                  95      


Tyr Asn Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser His Val Ile 
            100                 105                 110         


Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Ser Cys 
        115                 120                 125             


Phe Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys Asn Lys Phe 
    130                 135                 140                 


Val Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr Glu Lys Phe 
145                 150                 155                 160 


Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu Leu Thr Ser 
                165                 170                 175     


Arg Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
            180                 185                 


<210>  8269
<211>  1625
<212>  DNA
<213>  Homosapiens

<400>  8269
cagtgctgtg caggatggag tccagacacc cagcagtagc agaaatcgcc tgtacgtgtt     60

tgggcccttc ttcatctggc aaaccccgaa ggaagggggc atctctgccg gccttgccac    120

aaccgtgaga aggccaaggg cctgggcaag tacatctgcc agcggtgcca cctggtcatc    180

gacgagcagc ccctcatgtt caggagcgac gcctaccacc ctgaccactt caactgcacc    240

cactgtggga aggagctgac agccgaggcc cgcgagctga agggtgagct ctactgcctg    300

ccctgccatg acaagatggg cgtccccatc tgcggggcct gccgccggcc catcgagggc    360

cgagtggtca acgcgctggg caagcagtgg cacgtggagc actttgtctg tgccaagtgt    420

gagaagccat tcctggggca ccggcactat gagaagaagg gcctggccta ctgcgagact    480

cactacaacc agctcttcgg ggacgtctgc tacaactgca gccatgtgat tgaaggcgat    540

gtggtgtcgg ccctcaacaa ggcctggtgt gtgagctgct tctcctgctc cacctgcaac    600

agcaagctca ccctgaagaa caagtttgtg gagttcgaca tgaagcccgt gtgtaagagg    660

tgctacgaga agttcccgct ggagctgaag aagcggctga agaagctgtc ggagctgacc    720

tcccgcaagg cccagcccaa ggccacagac ctcaactctg cctgaaggcc ctcttgcgca    780

gctgcctctc ggcccctccg ccttctcccc tcctgctgtc catgcttggc cccctcgtcc    840

ccatccacct gtgccctccg catcttaccc tccctttctc tttcctcatt gccttctccc    900

ttcctgttcc ctcatctctg ccttccccat gtctctcctc tccttggccg tggcttctgt    960

ctgtgaggag gcaggagctg gggagtggga gcctatgacc ccacgtctga cagccatgtc   1020

cacctgtgcc cacagcttcc gcccacagac ctccagggac aggagcaaat tgcaccacag   1080

ctccccgcct ggcctggccc tccccaggcg gctcagtggc tcatgctgtc ctgtgagagc   1140

ccctgcccca gagcggcccc actaagcgca tgtggctcct gggctaccca cagccagggc   1200

agcctgctgg agccacaggg ccagggccat gcagatggag gcctctggga gccacctcca   1260

atccctcacc actcactcaa ccagtggcac agtgtccttg tgcccacact gagccagcaa   1320

gtcctgctgt ccacacccac aagctacctg gagggacagg acccacctcc atccttcgga   1380

aggccttcct ggaatcccac cttggcctcc gccctcggtt ccgccccgcc cctctccccc   1440

cgaccttggg gcttgtgtcg agcccttggg tggggccagg aggaggtgat ggcgtcagag   1500

gaggtgtggt cagaggtgac ttgttcccac ctccagggag gacgcttcgt cttcggccag   1560

cgcagacctg gtgtttgttt gttgggctca cgcttgcaca atgaaggctt gttcacacaa   1620

ccaca                                                               1625


<210>  8270
<211>  189
<212>  PRT
<213>  Homosapiens

<400>  8270

Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn Cys Thr His 
1               5                   10                  15      


Cys Gly Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys Gly Glu Leu 
            20                  25                  30          


Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile Cys Gly Ala 
        35                  40                  45              


Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu Gly Lys Gln 
    50                  55                  60                  


Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe Leu 
65                  70                  75                  80  


Gly His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys Glu Thr His 
                85                  90                  95      


Tyr Asn Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser His Val Ile 
            100                 105                 110         


Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Ser Cys 
        115                 120                 125             


Phe Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys Asn Lys Phe 
    130                 135                 140                 


Val Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr Glu Lys Phe 
145                 150                 155                 160 


Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu Leu Thr Ser 
                165                 170                 175     


Arg Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
            180                 185                 


<210>  8271
<211>  493
<212>  DNA
<213>  Homosapiens

<400>  8271
gcacagagag ccagtcggca gcttagccag tgactgctgg gcctttgttt gggccccttg     60

ccctgcacac agctgatgat gagacacccc agggccatgc agatggaggc ctctgggagc    120

cacctccaat ccctcaccac tcactcaacc agtggcacag tgtccttgtg cccacactga    180

gccagcaagt cctgctgtcc acacccacaa gctacctgga gggacaggac ccacctccat    240

ccttcggaag gccttcctgg aatcccacct tggcctccgc cctcggttcc gccccgcccc    300

tctccccccg accttggggc ttgtgtcgag cccttgggtg gggccaggag gaggtgatgg    360

cgtcagagga ggtgtggtca gaggtgactt gttcccacct ccagggagga cgcttcgtct    420

tcggccagcg cagacctggt gtttgtttgt tgggctcacg cttgcacaat gaaggcttgt    480

tcacacaacc aca                                                       493


<210>  8272
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  8272

Met Met Arg His Pro Arg Ala Met Gln Met Glu Ala Ser Gly Ser His 
1               5                   10                  15      


Leu Gln Ser Leu Thr Thr His Ser Thr Ser Gly Thr Val Ser Leu Cys 
            20                  25                  30          


Pro His 
        


<210>  8273
<211>  1693
<212>  DNA
<213>  Homosapiens

<400>  8273
cagggtctgt tcttagtcca atgtggagtt cctcatgggg accccattcc ccaggaatcc     60

aggttccaca gtactctgac ttggtctggc tggtctcggc tggcactttc cctaggactg    120

ctaaaaccac ggtgagggcg gagagctgag ggccgaagaa ggcggggcat ctctgccggc    180

cttgccacaa ccgtgagaag gccaagggcc tgggcaagta catctgccag cggtgccacc    240

tggtcatcga cgagcagccc ctcatgttca ggagcgacgc ctaccaccct gaccacttca    300

actgcaccca ctgtgggaag gagctgacag ccgaggcccg cgagctgaag ggtgagctct    360

actgcctgcc ctgccatgac aagatgggcg tccccatctg cggggcctgc cgccggccca    420

tcgagggccg agtggtcaac gcgctgggca agcagtggca cgtggagcac tttgtctgtg    480

ccaagtgtga gaagccattc ctggggcacc ggcactatga gaagaagggc ctggcctact    540

gcgagactca ctacaaccag ctcttcgggg acgtctgcta caactgcagc catgtgattg    600

aaggcgatgt ggtgtcggcc ctcaacaagg cctggtgtgt gagctgcttc tcctgctcca    660

cctgcaacag caagctcacc ctgaagaaca agtttgtgga gttcgacatg aagcccgtgt    720

gtaagaggtg ctacgagaag ttcccgctgg agctgaagaa gcggctgaag aagctgtcgg    780

agctgacctc ccgcaaggcc cagcccaagg ccacagacct caactctgcc tgaaggccct    840

cttgcgcagc tgcctctcgg cccctccgcc ttctcccctc ctgctgtcca tgcttggccc    900

cctcgtcccc atccacctgt gccctccgca tcttaccctc cctttctctt tcctcattgc    960

cttctccctt cctgttccct catctctgcc ttccccatgt ctctcctctc cttggccgtg   1020

gcttctgtct gtgaggaggc aggagctggg gagtgggagc ctatgacccc acgtctgaca   1080

gccatgtcca cctgtgccca cagcttccgc ccacagacct ccagggacag gagcaaattg   1140

caccacagct ccccgcctgg cctggccctc cccaggcggc tcagtggctc atgctgtcct   1200

gtgagagccc ctgccccaga gcggccccac taagcgcatg tggctcctgg gctacccaca   1260

gccagggcag cctgctggag ccacagggcc agggccatgc agatggaggc ctctgggagc   1320

cacctccaat ccctcaccac tcactcaacc agtggcacag tgtccttgtg cccacactga   1380

gccagcaagt cctgctgtcc acacccacaa gctacctgga gggacaggac ccacctccat   1440

ccttcggaag gccttcctgg aatcccacct tggcctccgc cctcggttcc gccccgcccc   1500

tctccccccg accttggggc ttgtgtcgag cccttgggtg gggccaggag gaggtgatgg   1560

cgtcagagga ggtgtggtca gaggtgactt gttcccacct ccagggagga cgcttcgtct   1620

tcggccagcg cagacctggt gtttgtttgt tgggctcacg cttgcacaat gaaggcttgt   1680

tcacacaacc aca                                                      1693


<210>  8274
<211>  189
<212>  PRT
<213>  Homosapiens

<400>  8274

Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn Cys Thr His 
1               5                   10                  15      


Cys Gly Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys Gly Glu Leu 
            20                  25                  30          


Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile Cys Gly Ala 
        35                  40                  45              


Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu Gly Lys Gln 
    50                  55                  60                  


Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe Leu 
65                  70                  75                  80  


Gly His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys Glu Thr His 
                85                  90                  95      


Tyr Asn Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser His Val Ile 
            100                 105                 110         


Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Ser Cys 
        115                 120                 125             


Phe Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys Asn Lys Phe 
    130                 135                 140                 


Val Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr Glu Lys Phe 
145                 150                 155                 160 


Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu Leu Thr Ser 
                165                 170                 175     


Arg Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
            180                 185                 


<210>  8275
<211>  1471
<212>  DNA
<213>  Homosapiens

<400>  8275
ggcaaacgca gaaccagggc ttggaatttc gccgctatgc agctgcaccc ctgccaccca     60

ggagatctga ggctcctcag agctgggagg accgggcatc tctgccggcc ttgccacaac    120

cgtgagaagg ccaagggcct gggcaagtac atctgccagc ggtgccacct ggtcatcgac    180

gagcagcccc tcatgttcag gagcgacgcc taccaccctg accacttcaa ctgcacccac    240

tgtggcactt tgtctgtgcc aagtgtgaga agccattcct ggggcaccgg cactatgaga    300

agaagggcct ggcctactgc gagactcact acaaccagct cttcggggac gtctgctaca    360

actgcagcca tgtgattgaa ggcgatgtgg tgtcggccct caacaaggcc tggtgtgtga    420

gctgcttctc ctgctccacc tgcaacagca agctcaccct gaagaacaag tttgtggagt    480

tcgacatgaa gcccgtgtgt aagaggtgct acgagaagtt cccgctggag ctgaagaagc    540

ggctgaagaa gctgtcggag ctgacctccc gcaaggccca gcccaaggcc acagacctca    600

actctgcctg aaggccctct tgcgcagctg cctctcggcc cctccgcctt ctcccctcct    660

gctgtccatg cttggccccc tcgtccccat ccacctgtgc cctccgcatc ttaccctccc    720

tttctctttc ctcattgcct tctcccttcc tgttccctca tctctgcctt ccccatgtct    780

ctcctctcct tggccgtggc ttctgtctgt gaggaggcag gagctgggga gtgggagcct    840

atgaccccac gtctgacagc catgtccacc tgtgcccaca gcttccgccc acagacctcc    900

agggacagga gcaaattgca ccacagctcc ccgcctggcc tggccctccc caggcggctc    960

agtggctcat gctgtcctgt gagagcccct gccccagagc ggccccacta agcgcatgtg   1020

gctcctgggc tacccacagc cagggcagcc tgctggagcc acagggccag ggccatgcag   1080

atggaggcct ctgggagcca cctccaatcc ctcaccactc actcaaccag tggcacagtg   1140

tccttgtgcc cacactgagc cagcaagtcc tgctgtccac acccacaagc tacctggagg   1200

gacaggaccc acctccatcc ttcggaaggc cttcctggaa tcccaccttg gcctccgccc   1260

tcggttccgc cccgcccctc tccccccgac cttggggctt gtgtcgagcc cttgggtggg   1320

gccaggagga ggtgatggcg tcagaggagg tgtggtcaga ggtgacttgt tcccacctcc   1380

agggaggacg cttcgtcttc ggccagcgca gacctggtgt ttgtttgttg ggctcacgct   1440

tgcacaatga aggcttgttc acacaaccac a                                  1471


<210>  8276
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  8276

Met Gln Leu His Pro Cys His Pro Gly Asp Leu Arg Leu Leu Arg Ala 
1               5                   10                  15      


Gly Arg Thr Gly His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala 
            20                  25                  30          


Lys Gly Leu Gly Lys Tyr Ile Cys Gln Arg Cys His Leu Val Ile Asp 
        35                  40                  45              


Glu Gln Pro Leu Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe 
    50                  55                  60                  


Asn Cys Thr His Cys Gly Thr Leu Ser Val Pro Ser Val Arg Ser His 
65                  70                  75                  80  


Ser Trp Gly Thr Gly Thr Met Arg Arg Arg Ala Trp Pro Thr Ala Arg 
                85                  90                  95      


Leu Thr Thr Thr Ser Ser Ser Gly Thr Ser Ala Thr Thr Ala Ala Met 
            100                 105                 110         


<210>  8277
<211>  1643
<212>  DNA
<213>  Homosapiens

<400>  8277
gcattctgaa cttcagcaca aggcaaacgc agaaccaggg cttggaattt cgccgctatg     60

cagctgcacc cctgccaccc aggagatctg aggctcctca gagctgggag gaccgggcat    120

ctctgccggc cttgccacaa ccgtgagaag gccaagggcc tgggcaagta catctgccag    180

cggtgccacc tggtcatcga cgagcagccc ctcatgttca ggagcgacgc ctaccaccct    240

gaccacttca actgcaccca ctgtgggaag gagctgacag ccgaggcccg cgagctgaag    300

ggtgagctct actgcctgcc ctgccatgac aagatgggcg tccccatctg cggggcctgc    360

cgccggccca tcgagggccg agtggtcaac gcgctgggca agcagtggca cgtggagcac    420

tttgtctgtg ccaagtgtga gaagccattc ctggggcacc ggcactatga gaagaagggc    480

ctggcctact gcgagactca ctacaaccag ctcttcgggg acgtctgcta caactgcagc    540

catgtgattg aaggcgatgt ggtgtcggcc ctcaacaagg cctggtgtgt gagctgcttc    600

tcctgctcca cctgcaacag caagctcacc ctgaagaaca agtttgtgga gttcgacatg    660

aagcccgtgt gtaagaggtg ctacgagaag ttcccgctgg agctgaagaa gcggctgaag    720

aagctgtcgg agctgacctc ccgcaaggcc cagcccaagg ccacagacct caactctgcc    780

tgaaggccct cttgcgcagc tgcctctcgg cccctccgcc ttctcccctc ctgctgtcca    840

tgcttggccc cctcgtcccc atccacctgt gccctccgca tcttaccctc cctttctctt    900

tcctcattgc cttctccctt cctgttccct catctctgcc ttccccatgt ctctcctctc    960

cttggccgtg gcttctgtct gtgaggaggc aggagctggg gagtgggagc ctatgacccc   1020

acgtctgaca gccatgtcca cctgtgccca cagcttccgc ccacagacct ccagggacag   1080

gagcaaattg caccacagct ccccgcctgg cctggccctc cccaggcggc tcagtggctc   1140

atgctgtcct gtgagagccc ctgccccaga gcggccccac taagcgcatg tggctcctgg   1200

gctacccaca gccagggcag cctgctggag ccacagggcc agggccatgc agatggaggc   1260

ctctgggagc cacctccaat ccctcaccac tcactcaacc agtggcacag tgtccttgtg   1320

cccacactga gccagcaagt cctgctgtcc acacccacaa gctacctgga gggacaggac   1380

ccacctccat ccttcggaag gccttcctgg aatcccacct tggcctccgc cctcggttcc   1440

gccccgcccc tctccccccg accttggggc ttgtgtcgag cccttgggtg gggccaggag   1500

gaggtgatgg cgtcagagga ggtgtggtca gaggtgactt gttcccacct ccagggagga   1560

cgcttcgtct tcggccagcg cagacctggt gtttgtttgt tgggctcacg cttgcacaat   1620

gaaggcttgt tcacacaacc aca                                           1643


<210>  8278
<211>  241
<212>  PRT
<213>  Homosapiens

<400>  8278

Met Gln Leu His Pro Cys His Pro Gly Asp Leu Arg Leu Leu Arg Ala 
1               5                   10                  15      


Gly Arg Thr Gly His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala 
            20                  25                  30          


Lys Gly Leu Gly Lys Tyr Ile Cys Gln Arg Cys His Leu Val Ile Asp 
        35                  40                  45              


Glu Gln Pro Leu Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe 
    50                  55                  60                  


Asn Cys Thr His Cys Gly Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu 
65                  70                  75                  80  


Lys Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro 
                85                  90                  95      


Ile Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala 
            100                 105                 110         


Leu Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu 
        115                 120                 125             


Lys Pro Phe Leu Gly His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr 
    130                 135                 140                 


Cys Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys 
145                 150                 155                 160 


Ser His Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp 
                165                 170                 175     


Cys Val Ser Cys Phe Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu 
            180                 185                 190         


Lys Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys 
        195                 200                 205             


Tyr Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser 
    210                 215                 220                 


Glu Leu Thr Ser Arg Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser 
225                 230                 235                 240 


Ala 
    


<210>  8279
<211>  1712
<212>  DNA
<213>  Homosapiens

<400>  8279
cctggcgtcc ggcccactgt cctcggagct gggcggtgcc tggcattgag cagcttgtct     60

aaatgaaggg ctgaggggca gacggtgcag tgcaggggcc gagggacagc accaggagct    120

cgtgctgacc agcaacgtcg ccgacagggt gtgtggagcg agcccaatct ccttcctgag    180

ccaaggcatc tctgccggcc ttgccacaac cgtgagaagg ccaagggcct gggcaagtac    240

atctgccagc ggtgccacct ggtcatcgac gagcagcccc tcatgttcag gagcgacgcc    300

taccaccctg accacttcaa ctgcacccac tgtgggaagg agctgacagc cgaggcccgc    360

gagctgaagg gtgagctcta ctgcctgccc tgccatgaca agatgggcgt ccccatctgc    420

ggggcctgcc gccggcccat cgagggccga gtggtcaacg cgctgggcaa gcagtggcac    480

gtggagcact ttgtctgtgc caagtgtgag aagccattcc tggggcaccg gcactatgag    540

aagaagggcc tggcctactg cgagactcac tacaaccagc tcttcgggga cgtctgctac    600

aactgcagcc atgtgattga aggcgatgtg gtgtcggccc tcaacaaggc ctggtgtgtg    660

agctgcttct cctgctccac ctgcaacagc aagctcaccc tgaagaacaa gtttgtggag    720

ttcgacatga agcccgtgtg taagaggtgc tacgagaagt tcccgctgga gctgaagaag    780

cggctgaaga agctgtcgga gctgacctcc cgcaaggccc agcccaaggc cacagacctc    840

aactctgcct gaaggccctc ttgcgcagct gcctctcggc ccctccgcct tctcccctcc    900

tgctgtccat gcttggcccc ctcgtcccca tccacctgtg ccctccgcat cttaccctcc    960

ctttctcttt cctcattgcc ttctcccttc ctgttccctc atctctgcct tccccatgtc   1020

tctcctctcc ttggccgtgg cttctgtctg tgaggaggca ggagctgggg agtgggagcc   1080

tatgacccca cgtctgacag ccatgtccac ctgtgcccac agcttccgcc cacagacctc   1140

cagggacagg agcaaattgc accacagctc cccgcctggc ctggccctcc ccaggcggct   1200

cagtggctca tgctgtcctg tgagagcccc tgccccagag cggccccact aagcgcatgt   1260

ggctcctggg ctacccacag ccagggcagc ctgctggagc cacagggcca gggccatgca   1320

gatggaggcc tctgggagcc acctccaatc cctcaccact cactcaacca gtggcacagt   1380

gtccttgtgc ccacactgag ccagcaagtc ctgctgtcca cacccacaag ctacctggag   1440

ggacaggacc cacctccatc cttcggaagg ccttcctgga atcccacctt ggcctccgcc   1500

ctcggttccg ccccgcccct ctccccccga ccttggggct tgtgtcgagc ccttgggtgg   1560

ggccaggagg aggtgatggc gtcagaggag gtgtggtcag aggtgacttg ttcccacctc   1620

cagggaggac gcttcgtctt cggccagcgc agacctggtg tttgtttgtt gggctcacgc   1680

ttgcacaatg aaggcttgtt cacacaacca ca                                 1712


<210>  8280
<211>  189
<212>  PRT
<213>  Homosapiens

<400>  8280

Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn Cys Thr His 
1               5                   10                  15      


Cys Gly Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys Gly Glu Leu 
            20                  25                  30          


Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile Cys Gly Ala 
        35                  40                  45              


Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu Gly Lys Gln 
    50                  55                  60                  


Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe Leu 
65                  70                  75                  80  


Gly His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys Glu Thr His 
                85                  90                  95      


Tyr Asn Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser His Val Ile 
            100                 105                 110         


Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Ser Cys 
        115                 120                 125             


Phe Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys Asn Lys Phe 
    130                 135                 140                 


Val Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr Glu Lys Phe 
145                 150                 155                 160 


Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu Leu Thr Ser 
                165                 170                 175     


Arg Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
            180                 185                 


<210>  8281
<211>  4811
<212>  DNA
<213>  Homosapiens

<400>  8281
gatggggtta tttctgtcca ttgtgctggt gtggccactg cacatctccc ctcaagtcca     60

catcgatgtc atgttggcag ccaggagttg gccatgacgg gaatattcac accatggaca    120

ctggcaaacg ccccacagca gggcctgcct ctgcgcccca gagagctggc tgttgagcat    180

ttaccagaac atcacttgtg cttgtggtgg cggtggtggc caggggtcag atgctggctc    240

tgtttcaagg tagagctgat gggactggct ggtggatgga tgtggggcct gtggtccgcc    300

tggcagagca agagccgctg ttcctcacag tgtcttcagc ctcctgagga atgctgtcta    360

agtgtagagg cagcgggagg ggtgggcaaa gctctaggag gggtggccat atgcccagaa    420

caaagcctct ctctctcaca cacagcaggt gcccagaaga ttttcattgc tgaaagagtt    480

taagcccttc ctgactctac aggtcactgg gtagggctat atccagttta gtctaataag    540

acactcattt tagagaacag ggaaaaacca attaaaaaac agaaaataca attgttagag    600

gaaagcagag gcaggctttg gccccgcttg tggccagcac aggggccctc gctggcagct    660

gccgcctgga gggtgtgcac actggctcct gctggccgca gccctgagct cttcccactt    720

ccccgtgccc aggcccttcc tgcgttccct tccttctgtc tcctataccc gggtcttcat    780

ggcctctgag agagctggat actcccacag agaaggtata cgaaatagga ccaagtgaca    840

ctacacttca gactggatct catccctcct ggcttaaaac cgcctcgccc ccagcctgtt    900

ctccggacca acagggtcca gatcctcagt agacaccagt ggccctttga caggtggcct    960

cacggacctc tccagcttcc acgggggcac ctccctttgc accccaccat cccaaaaggg   1020

ccagtgtcct ctctggccag gcctgggacc cactgctcca gcctcagccc ggcatgcccc   1080

tgcctcagtg cctcatcccc tgctgtcagg tcctgaccca acaagggcct gggctgctca   1140

tggggatgat aggtggtttg cttgtcctct ctctgcgacc cctttgcagt ttgaaggccg   1200

gaagtactgc gaacacgact tccaaatgct gtttgctccg tgctgtggat cctgcggtga   1260

gttcatcatt ggccgcgtca tcaaggccat gaacaacaac tggcacccgg gctgcttccg   1320

ctgcgagctg tgtgatgtgg agctggctga cctgggcttt gtgaagaatg ccggcaggca   1380

tctctgccgg ccttgccaca accgtgagaa ggccaagggc ctgggcaagt acatctgcca   1440

gcggtgccac ctggtcatcg acgagcagcc cctcatgttc aggagcgacg cctaccaccc   1500

tgaccacttc aactgcaccc actgtgggta ggtgcgcagc ccggccctgc agttgtgggg   1560

gcggggagcc agggctggcc cagggtaagg gcggtggggc ctccacctgg ggaagtgttg   1620

aggagggaga ggggagcagg gtgggcagac agaggggtcc cgagagcaag gctgcagggc   1680

agaggtgggc tgggggctgg gaagcagcca tggcaggaag cttctctctc cagggctctg   1740

tttggggggc acttgagact caggaggcgg gtgggctgga cccctagact gcagacgagg   1800

gttgagatgg agcagtggaa gggacctgag ggggcagggc aagagaccgg gagtgggctt   1860

ggtgctggtg ttggagagag gagttgcata ggcagcccct cagcccccgt cctcgcccac   1920

ccccaccgtc ccctccagtc ctctccgtgc ctatccagac accccctctg gtttggagga   1980

ggaggggggc ccaagaacag acctgcttct cagaggcctg ggtgcagaac acagcccact   2040

cttctgggct gtgcaggaag tctgtgctcc agggcctgtc tggggcacag gaagtcttca   2100

aagtgcccag agatcagaag gcgctgccgc ctcggctctg cagggacaga atgggcccct   2160

cggggagccg tgccctgggg tggaggcgct gctggcatga ccctgcagaa gggcaggggt   2220

ggcacctggg ggctgcacgc tgtcttccag gaaggagctg acagccgagg cccgcgagct   2280

gaagggtgag ctctactgcc tgccctgcca tgacaagatg ggcgtcccca tctgcggggc   2340

ctgccgccgg cccatcgagg gccgagtggt caacgcgctg ggcaagcagt ggcacgtgga   2400

ggtgagccag gctggtggac acgtggcctc aggttggggg gtgccccagc tcagggtcat   2460

ggtaagagcc ctaaagctcc tccacactcc cagcccaggg cgggtggctg gctcccaacg   2520

aggcccttcc tcaggggtac tgcccctccc tgtgctcagc cagggacccc agcctgccca   2580

cgggagccag gagacccgag tgcacacaca cggttgggta gctgtgccca cctctcctct   2640

tccccctgct ggcattctaa gagactccaa ggtcaggaga aaaccttggg ggcagtctgt   2700

ccagagtgcc tgggggttgt ggatgacaga acccgctgca tggacagccc tgtgcagaca   2760

cggagctgaa gagttcctca ggtgtgagca ctgggtcacc tggagtgccc ccaccgggtg   2820

gtgggctctc atgttctcat gggtacactg ggaacagtga gcccaccacc tcccctgatg   2880

acctggccag cgctgtgtcc ggaagctgtg ccttgggtgg cggcttgggt gggaggccat   2940

gcggtcctgc cctgatgcag gccccagccc ccagccctca tcctcacatg cagatccctg   3000

ggggaatgca aggtgctgct cagtgatccc aggcttgcag ggggtgcctg caggaggccc   3060

cacgtggaca ggcagggccg cctctgccta tgagggccca ccatgccgca gcaccaggct   3120

ggcacctgac tcctggggct gaggctgccg agggggaggc cagactggga ggggatggtg   3180

actcacaagg ttaccatcag tgccttagag gaggggtagg gtctgctgac cccagggcat   3240

tcacagaggt gtcagtcccc tctgcccagt gtgaatcctg aaaggcctgc acctgcccag   3300

actctgcttt ctgtcccctt ctgtcactgc tgcctcctgg ggccactgtg gtcccctgga   3360

gtcactggct cctggggtca ctgttgtccc cgggtcacca ctgtccctcg gggtcaccgc   3420

tctagccctg atgccacccg gcccgccctt tgtccttgca gcactttgtc tgtgccaagt   3480

gtgagaagcc attcctgggg caccggcact atgagaagaa gggcctggcc tactgcgaga   3540

ctcactacaa ccagctcttc ggggacgtct gctacaactg cagccatgtg attgaaggcg   3600

atggtgaggc cctgtgttcc ctcccccacc ccacctgctc tcctggggcc tgggtgctgc   3660

agctgtgagc ccagccgggc ctgcggcagc ctagccaggc ctgctgagtc ccacgcttcc   3720

ctcacagtgg tgtcggccct caacaaggcc tggtgtgtga gctgcttctc ctgctccacc   3780

tgcaacagca agctcaccct gaagaacaag tttgtggagt tcgacatgaa gcccgtgtgt   3840

aagaggtgct acgagaagtt cccgctggag ctgaagaagc ggctgaagaa gctgtcggag   3900

ctgacctccc gcaaggccca gcccaaggcc acagacctca actctgcctg aaggccctct   3960

tgcgcagctg cctctcggcc cctccgcctt ctcccctcct gctgtccatg cttggccccc   4020

tcgtccccat ccacctgtgc cctccgcatc ttaccctccc tttctctttc ctcattgcct   4080

tctcccttcc tgttccctca tctctgcctt ccccatgtct ctcctctcct tggccgtggc   4140

ttctgtctgt gaggaggcag gagctgggga gtgggagcct atgaccccac gtctgacagc   4200

catgtccacc tgtgcccaca gcttccgccc acagacctcc agggacagga gcaaattgca   4260

ccacagctcc ccgcctggcc tggccctccc caggcggctc agtggctcat gctgtcctgt   4320

gagagcccct gccccagagc ggccccacta agcgcatgtg gctcctgggc tacccacagc   4380

cagggcagcc tgctggagcc acagggccag ggccatgcag atggaggcct ctgggagcca   4440

cctccaatcc ctcaccactc actcaaccag tggcacagtg tccttgtgcc cacactgagc   4500

cagcaagtcc tgctgtccac acccacaagc tacctggagg gacaggaccc acctccatcc   4560

ttcggaaggc cttcctggaa tcccaccttg gcctccgccc tcggttccgc cccgcccctc   4620

tccccccgac cttggggctt gtgtcgagcc cttgggtggg gccaggagga ggtgatggcg   4680

tcagaggagg tgtggtcaga ggtgacttgt tcccacctcc agggaggacg cttcgtcttc   4740

ggccagcgca gacctggtgt ttgtttgttg ggctcacgct tgcacaatga aggcttgttc   4800

acacaaccac a                                                        4811


<210>  8282
<211>  139
<212>  PRT
<213>  Homosapiens

<400>  8282

Met Pro Ala Gly Ile Ser Ala Gly Leu Ala Thr Thr Val Arg Arg Pro 
1               5                   10                  15      


Arg Ala Trp Ala Ser Thr Ser Ala Ser Gly Ala Thr Trp Ser Ser Thr 
            20                  25                  30          


Ser Ser Pro Ser Cys Ser Gly Ala Thr Pro Thr Thr Leu Thr Thr Ser 
        35                  40                  45              


Thr Ala Pro Thr Val Gly Arg Cys Ala Ala Arg Pro Cys Ser Cys Gly 
    50                  55                  60                  


Gly Gly Glu Pro Gly Leu Ala Gln Gly Lys Gly Gly Gly Ala Ser Thr 
65                  70                  75                  80  


Trp Gly Ser Val Glu Glu Gly Glu Gly Ser Arg Val Gly Arg Gln Arg 
                85                  90                  95      


Gly Pro Glu Ser Lys Ala Ala Gly Gln Arg Trp Ala Gly Gly Trp Glu 
            100                 105                 110         


Ala Ala Met Ala Gly Ser Phe Ser Leu Gln Gly Ser Val Trp Gly Ala 
        115                 120                 125             


Leu Glu Thr Gln Glu Ala Gly Gly Leu Asp Pro 
    130                 135                 


<210>  8283
<211>  2470
<212>  DNA
<213>  Homosapiens

<400>  8283
tcccacttca gcctccagag tagctgagac tacaggcttg caccaccaca cctggctaat     60

ttttttgttt tcttgtattt ttattagaga tggattcttg ccatattgcc caggctggtc    120

tcgaactcct gggctcaagg gatccgccca ccttggcctc ccacagtgct ctggatgaca    180

ggcttgagcc attctgcaca cgcacccagc taccctcttg cctgctctgt gtttgggtgg    240

ttatgtgttt attggaggca gtcagtttga aactaactca tggtgcagag gatggaacca    300

tggaagactg agcagtctgg attcaagtgt ggaccccgct ctgctgtgtg agcttgggca    360

agttactcaa cctctttgag gcttaggtcc cttttctgga agaggccata ataatagtag    420

ctgcagtatt gccctgggga ttaaatgaga gtgtgaatac agagccgctc acctgtgctg    480

ggtggtgttc tgtgtgcgag actctctggt ccctgaagaa ggggtaatag gggcccaagt    540

gggagttgac tgggcccctg acaccccaag gggtgggcac tacaagcact gagcagcctg    600

gaccctgggt tagagcgatt ttcctgatcc tgcagagcgt cttcactttt taatacgagg    660

tgtgtctgtc gggcgcaggc ccccgcgtgt gccccatctg cacccctgac cagctctgac    720

tcactcctcc tgtctcctgc ccccagcaat atgtcggacg ccttggccaa cgccgtgtgc    780

cagcgctgcc aggcccgctt ctcccccgcc gagcgcattg tcaacagcaa tggggagctg    840

taccatgagc actgcttcgt gtgtgcccag tgcttccggc ccttccccga ggggctcttc    900

tatgagtttg aaggccggaa gtactgcgaa cacgacttcc aaatgctgtt tgctccgtgc    960

tgtggatcct gcggtgagtt catcattggc cgcgtcatca aggccatgaa caacaactgg   1020

cacccgggct gcttccgctg cgagctgtgt gatgtggagc tggctgacct gggctttgtg   1080

aagaatgccg gcaggcatct ctgccggcct tgccacaacc gtgagaaggc caagggcctg   1140

ggcaagtaca tctgccagcg gtgccacctg gtcatcgacg agcagcccct catgttcagg   1200

agcgacgcct accaccctga ccacttcaac tgcacccact gtggcacttt gtctgtgcca   1260

agtgtgagaa gccattcctg gggcaccggc actatgagaa gaagggcctg gcctactgcg   1320

agactcacta caaccagctc ttcggggacg tctgctacaa ctgcagccat gtgattgaag   1380

gcgatgtggt gtcggccctc aacaaggcct ggtgtgtgag ctgcttctcc tgctccacct   1440

gcaacagcaa gctcaccctg aagaacaagt ttgtggagtt cgacatgaag cccgtgtgta   1500

agaggtgcta cgagaagttc ccgctggagc tgaagaagcg gctgaagaag ctgtcggagc   1560

tgacctcccg caaggcccag cccaaggcca cagacctcaa ctctgcctga aggccctctt   1620

gcgcagctgc ctctcggccc ctccgccttc tcccctcctg ctgtccatgc ttggccccct   1680

cgtccccatc cacctgtgcc ctccgcatct taccctccct ttctctttcc tcattgcctt   1740

ctcccttcct gttccctcat ctctgccttc cccatgtctc tcctctcctt ggccgtggct   1800

tctgtctgtg aggaggcagg agctggggag tgggagccta tgaccccacg tctgacagcc   1860

atgtccacct gtgcccacag cttccgccca cagacctcca gggacaggag caaattgcac   1920

cacagctccc cgcctggcct ggccctcccc aggcggctca gtggctcatg ctgtcctgtg   1980

agagcccctg ccccagagcg gccccactaa gcgcatgtgg ctcctgggct acccacagcc   2040

agggcagcct gctggagcca cagggccagg gccatgcaga tggaggcctc tgggagccac   2100

ctccaatccc tcaccactca ctcaaccagt ggcacagtgt ccttgtgccc acactgagcc   2160

agcaagtcct gctgtccaca cccacaagct acctggaggg acaggaccca cctccatcct   2220

tcggaaggcc ttcctggaat cccaccttgg cctccgccct cggttccgcc ccgcccctct   2280

ccccccgacc ttggggcttg tgtcgagccc ttgggtgggg ccaggaggag gtgatggcgt   2340

cagaggaggt gtggtcagag gtgacttgtt cccacctcca gggaggacgc ttcgtcttcg   2400

gccagcgcag acctggtgtt tgtttgttgg gctcacgctt gcacaatgaa ggcttgttca   2460

cacaaccaca                                                          2470


<210>  8284
<211>  207
<212>  PRT
<213>  Homosapiens

<400>  8284

Met Ser Asp Ala Leu Ala Asn Ala Val Cys Gln Arg Cys Gln Ala Arg 
1               5                   10                  15      


Phe Ser Pro Ala Glu Arg Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu His Cys Phe Val Cys Ala Gln Cys Phe Arg Pro Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
    50                  55                  60                  


Met Leu Phe Ala Pro Cys Cys Gly Ser Cys Gly Glu Phe Ile Ile Gly 
65                  70                  75                  80  


Arg Val Ile Lys Ala Met Asn Asn Asn Trp His Pro Gly Cys Phe Arg 
                85                  90                  95      


Cys Glu Leu Cys Asp Val Glu Leu Ala Asp Leu Gly Phe Val Lys Asn 
            100                 105                 110         


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Lys 
        115                 120                 125             


Gly Leu Gly Lys Tyr Ile Cys Gln Arg Cys His Leu Val Ile Asp Glu 
    130                 135                 140                 


Gln Pro Leu Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn 
145                 150                 155                 160 


Cys Thr His Cys Gly Thr Leu Ser Val Pro Ser Val Arg Ser His Ser 
                165                 170                 175     


Trp Gly Thr Gly Thr Met Arg Arg Arg Ala Trp Pro Thr Ala Arg Leu 
            180                 185                 190         


Thr Thr Thr Ser Ser Ser Gly Thr Ser Ala Thr Thr Ala Ala Met 
        195                 200                 205         


<210>  8285
<211>  2274
<212>  DNA
<213>  Homosapiens

<400>  8285
gcccgcgacc tcaaggcggc tgccccgcgc catggcggcc cggctgggtg cgctggccgc     60

gtcggggctg taccggcggc gccagcaccg gcagagcccg ccgccagcca cgggcaatat    120

gtcggacgcc ttggccaacg ccgtgtgcca gcgctgccag gcccgcttct cccccgccga    180

gcgcattgtc aacagcaatg gggagctgta ccatgagcac tgcttcgtgt gtgcccagtg    240

cttccggccc ttccccgagg ggctcttcta tgagtttgaa ggccggaagt actgcgaaca    300

cgacttccaa atgctgtttg ctccgtgctg tggatcctgc ggtaaggccg gtgacagtac    360

acatcctggg ctgcctggga agtgggcagc agtggcgggg ggcagggggc cgagggggta    420

cacagaactg gcccagctct ttcctaactc cccaccttgc ctctctgagc ggcagccgtc    480

aggcccccta caggcatcac catcccacga gggagcccat gggccaggca gagagcaggc    540

ggagtgctag gtggacaggg cttgggaggg tccgaagagg ggacaggcac gtgctcccca    600

gccagcaggg acctgtcttc ttccaggtga gttcatcatt ggccgcgtca tcaaggccat    660

gaacaacaac tggcacccgg gctgcttccg ctgcgagctg tgtgatgtgg agctggctga    720

cctgggcttt gtgaagaatg ccggcaggca tctctgccgg ccttgccaca accgtgagaa    780

ggccaagggc ctgggcaagt acatctgcca gcggtgccac ctggtcatcg acgagcagcc    840

cctcatgttc aggagcgacg cctaccaccc tgaccacttc aactgcaccc actgtgggaa    900

ggagctgaca gccgaggccc gcgagctgaa gggtgagctc tactgcctgc cctgccatga    960

caagatgggc gtccccatct gcggggcctg ccgccggccc atcgagggcc gagtggtcaa   1020

cgcgctgggc aagcagtggc acgtggagca ctttgtctgt gccaagtgtg agaagccatt   1080

cctggggcac cggcactatg agaagaaggg cctggcctac tgcgagactc actacaacca   1140

gctcttcggg gacgtctgct acaactgcag ccatgtgatt gaaggcgatg tggtgtcggc   1200

cctcaacaag gcctggtgtg tgagctgctt ctcctgctcc acctgcaaca gcaagctcac   1260

cctgaagaac aagtttgtgg agttcgacat gaagcccgtg tgtaagaggt gctacgagaa   1320

gttcccgctg gagctgaaga agcggctgaa gaagctgtcg gagctgacct cccgcaaggc   1380

ccagcccaag gccacagacc tcaactctgc ctgaaggccc tcttgcgcag ctgcctctcg   1440

gcccctccgc cttctcccct cctgctgtcc atgcttggcc ccctcgtccc catccacctg   1500

tgccctccgc atcttaccct ccctttctct ttcctcattg ccttctccct tcctgttccc   1560

tcatctctgc cttccccatg tctctcctct ccttggccgt ggcttctgtc tgtgaggagg   1620

caggagctgg ggagtgggag cctatgaccc cacgtctgac agccatgtcc acctgtgccc   1680

acagcttccg cccacagacc tccagggaca ggagcaaatt gcaccacagc tccccgcctg   1740

gcctggccct ccccaggcgg ctcagtggct catgctgtcc tgtgagagcc cctgccccag   1800

agcggcccca ctaagcgcat gtggctcctg ggctacccac agccagggca gcctgctgga   1860

gccacagggc cagggccatg cagatggagg cctctgggag ccacctccaa tccctcacca   1920

ctcactcaac cagtggcaca gtgtccttgt gcccacactg agccagcaag tcctgctgtc   1980

cacacccaca agctacctgg agggacagga cccacctcca tccttcggaa ggccttcctg   2040

gaatcccacc ttggcctccg ccctcggttc cgccccgccc ctctcccccc gaccttgggg   2100

cttgtgtcga gcccttgggt ggggccagga ggaggtgatg gcgtcagagg aggtgtggtc   2160

agaggtgact tgttcccacc tccagggagg acgcttcgtc ttcggccagc gcagacctgg   2220

tgtttgtttg ttgggctcac gcttgcacaa tgaaggcttg ttcacacaac caca         2274


<210>  8286
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  8286

Met Asn Asn Asn Trp His Pro Gly Cys Phe Arg Cys Glu Leu Cys Asp 
1               5                   10                  15      


Val Glu Leu Ala Asp Leu Gly Phe Val Lys Asn Ala Gly Arg His Leu 
            20                  25                  30          


Cys Arg Pro Cys His Asn Arg Glu Lys Ala Lys Gly Leu Gly Lys Tyr 
        35                  40                  45              


Ile Cys Gln Arg Cys His Leu Val Ile Asp Glu Gln Pro Leu Met Phe 
    50                  55                  60                  


Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn Cys Thr His Cys Gly 
65                  70                  75                  80  


Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys Gly Glu Leu Tyr Cys 
                85                  90                  95      


Leu Pro Cys His Asp Lys Met Gly Val Pro Ile Cys Gly Ala Cys Arg 
            100                 105                 110         


Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu Gly Lys Gln Trp His 
        115                 120                 125             


Val Glu His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe Leu Gly His 
    130                 135                 140                 


Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys Glu Thr His Tyr Asn 
145                 150                 155                 160 


Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser His Val Ile Glu Gly 
                165                 170                 175     


Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Ser Cys Phe Ser 
            180                 185                 190         


Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys Asn Lys Phe Val Glu 
        195                 200                 205             


Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr Glu Lys Phe Pro Leu 
    210                 215                 220                 


Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu Leu Thr Ser Arg Lys 
225                 230                 235                 240 


Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
                245                 250     


<210>  8287
<211>  2524
<212>  DNA
<213>  Homosapiens

<400>  8287
atcggctctg ccctggtctg ggtgccccac ggtgatgttt gtggcagagg gtctcagaga     60

agggagcaaa gcagaatgtg ggcctgtgtg gctccggtcc tcggtttcct aactgttggc    120

agggatccta aaggcgccag gtcctccctg tcctcctcag ctgactctgc cctcctcagt    180

gtgtccacgg gcacaggctt tcctcctggc aggtggcagc cggagacctc ctgggtgtcc    240

tgccgccact gtggacctca cctcagtgct gtctggggcc ttcccagacc agtcccctcc    300

cagcgggacc caacccccgc cagcctcagc tttcaggagc tgcccccgcg gcgcgaacaa    360

tatcctttct atttggagtt gactctgctg ccctttggag atcccagcgc gtaacgtgag    420

ctcgcgacca gcgcggggga ggcgcccaca cgcccgtccc gtcttggtgt ctggccccag    480

gcggccgcgc ctcccctccg aggtggtccc atagcccctg caccaggcgg cccgcgcccg    540

cgacctcaag gcggctgccc cgcgccatgg cggcccggct gggtgcgctg gccgcgtcgg    600

ggctgtaccg gcggcgccag caccggcaga gcccgccgcc agccacgggc aatatgtcgg    660

acgccttggc caacgccgtg tgccagcgct gccaggcccg cttctccccc gccgagcgca    720

ttgtcaacag caatggggag ctgtaccatg agcactgctt cgtgtgtgcc cagtgcttcc    780

ggcccttccc cgaggggctc ttctatgagt ttgaaggccg gaagtactgc gaacacgact    840

tccaaatgct gtttgctccg tgctgtggat cctgcggtga gttcatcatt ggccgcgtca    900

tcaaggccat gaacaacaac tggcacccgg gctgcttccg ctgcgagctg tgtgatgtgg    960

agctggctga cctgggcttt gtgaagaatg ccggcaggca tctctgccgg ccttgccaca   1020

accgtgagaa ggccaagggc ctgggcaagt acatctgcca gcggtgccac ctggtcatcg   1080

acgagcagcc cctcatgttc aggagcgacg cctaccaccc tgaccacttc aactgcaccc   1140

actgtgggaa ggagctgaca gccgaggccc gcgagctgaa gggtgagctc tactgcctgc   1200

cctgccatga caagatgggc gtccccatct gcggggcctg ccgccggccc atcgagggcc   1260

gagtggtcaa cgcgctgggc aagcagtggc acgtggagca ctttgtctgt gccaagtgtg   1320

agaagccatt cctggggcac cggcactatg agaagaaggg cctggcctac tgcgagactc   1380

actacaacca gctcttcggg gacgtctgct acaactgcag ccatgtgatt gaaggcgatg   1440

tggtgtcggc cctcaacaag gcctggtgtg tgagctgctt ctcctgctcc acctgcaaca   1500

gcaagctcac cctgaagaac aagtttgtgg agttcgacat gaagcccgtg tgtaagaggt   1560

gctacgagaa gttcccgctg gagctgaaga agcggctgaa gaagctgtcg gagctgacct   1620

cccgcaaggc ccagcccaag gccacagacc tcaactctgc ctgaaggccc tcttgcgcag   1680

ctgcctctcg gcccctccgc cttctcccct cctgctgtcc atgcttggcc ccctcgtccc   1740

catccacctg tgccctccgc atcttaccct ccctttctct ttcctcattg ccttctccct   1800

tcctgttccc tcatctctgc cttccccatg tctctcctct ccttggccgt ggcttctgtc   1860

tgtgaggagg caggagctgg ggagtgggag cctatgaccc cacgtctgac agccatgtcc   1920

acctgtgccc acagcttccg cccacagacc tccagggaca ggagcaaatt gcaccacagc   1980

tccccgcctg gcctggccct ccccaggcgg ctcagtggct catgctgtcc tgtgagagcc   2040

cctgccccag agcggcccca ctaagcgcat gtggctcctg ggctacccac agccagggca   2100

gcctgctgga gccacagggc cagggccatg cagatggagg cctctgggag ccacctccaa   2160

tccctcacca ctcactcaac cagtggcaca gtgtccttgt gcccacactg agccagcaag   2220

tcctgctgtc cacacccaca agctacctgg agggacagga cccacctcca tccttcggaa   2280

ggccttcctg gaatcccacc ttggcctccg ccctcggttc cgccccgccc ctctcccccc   2340

gaccttgggg cttgtgtcga gcccttgggt ggggccagga ggaggtgatg gcgtcagagg   2400

aggtgtggtc agaggtgact tgttcccacc tccagggagg acgcttcgtc ttcggccagc   2460

gcagacctgg tgtttgtttg ttgggctcac gcttgcacaa tgaaggcttg ttcacacaac   2520

caca                                                                2524


<210>  8288
<211>  365
<212>  PRT
<213>  Homosapiens

<400>  8288

Met Ala Ala Arg Leu Gly Ala Leu Ala Ala Ser Gly Leu Tyr Arg Arg 
1               5                   10                  15      


Arg Gln His Arg Gln Ser Pro Pro Pro Ala Thr Gly Asn Met Ser Asp 
            20                  25                  30          


Ala Leu Ala Asn Ala Val Cys Gln Arg Cys Gln Ala Arg Phe Ser Pro 
        35                  40                  45              


Ala Glu Arg Ile Val Asn Ser Asn Gly Glu Leu Tyr His Glu His Cys 
    50                  55                  60                  


Phe Val Cys Ala Gln Cys Phe Arg Pro Phe Pro Glu Gly Leu Phe Tyr 
65                  70                  75                  80  


Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln Met Leu Phe 
                85                  90                  95      


Ala Pro Cys Cys Gly Ser Cys Gly Glu Phe Ile Ile Gly Arg Val Ile 
            100                 105                 110         


Lys Ala Met Asn Asn Asn Trp His Pro Gly Cys Phe Arg Cys Glu Leu 
        115                 120                 125             


Cys Asp Val Glu Leu Ala Asp Leu Gly Phe Val Lys Asn Ala Gly Arg 
    130                 135                 140                 


His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Lys Gly Leu Gly 
145                 150                 155                 160 


Lys Tyr Ile Cys Gln Arg Cys His Leu Val Ile Asp Glu Gln Pro Leu 
                165                 170                 175     


Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn Cys Thr His 
            180                 185                 190         


Cys Gly Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys Gly Glu Leu 
        195                 200                 205             


Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile Cys Gly Ala 
    210                 215                 220                 


Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu Gly Lys Gln 
225                 230                 235                 240 


Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe Leu 
                245                 250                 255     


Gly His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys Glu Thr His 
            260                 265                 270         


Tyr Asn Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser His Val Ile 
        275                 280                 285             


Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Ser Cys 
    290                 295                 300                 


Phe Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys Asn Lys Phe 
305                 310                 315                 320 


Val Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr Glu Lys Phe 
                325                 330                 335     


Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu Leu Thr Ser 
            340                 345                 350         


Arg Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
        355                 360                 365 


<210>  8289
<211>  3101
<212>  DNA
<213>  Homosapiens

<400>  8289
atcggctctg ccctggtctg ggtgccccac ggtgatgttt gtggcagagg gtctcagaga     60

agggagcaaa gcagaatgtg ggcctgtgtg gctccggtcc tcggtttcct aactgttggc    120

agggatccta aaggcgccag gtcctccctg tcctcctcag ctgactctgc cctcctcagt    180

gtgtccacgg gcacaggctt tcctcctggc aggtggcagc cggagacctc ctgggtgtcc    240

tgccgccact gtggacctca cctcagtgct gtctggggcc ttcccagacc agtcccctcc    300

cagcgggacc caacccccgc cagcctcagc tttcaggagc tgcccccgcg gcgcgaacaa    360

tatcctttct atttggagtt gactctgctg ccctttggag atcccagcgc gtaacgtgag    420

ctcgcgacca gcgcggggga ggcgcccaca cgcccgtccc gtcttggtgt ctggccccag    480

gcggccgcgc ctcccctccg aggtggtccc atagcccctg caccaggcgg cccgcgcccg    540

cgacctcaag gcggctgccc cgcgccatgg cggcccggct gggtgcgctg gccgcgtcgg    600

ggctgtaccg gcggcgccag caccggcaga gcccgccgcc agccacgggc aatatgtcgg    660

acgccttggc caacgccgtg tgccagcgct gccaggcccg cttctccccc gccgagcgca    720

ttgtcaacag caatggggag ctgtaccatg agcactgctt cgtgtgtgcc cagtgcttcc    780

ggcccttccc cgaggggctc ttctatgagt ttgaaggccg gaagtactgc gaacacgact    840

tccaaatgct gtttgctccg tgctgtggat cctgcggtga gttcatcatt ggccgcgtca    900

tcaaggccat gaacaacaac tggcacccgg gctgcttccg ctgcgagctg tgtgatgtgg    960

agctggctga cctgggcttt gtgaagaatg ccggcaggca tctctgccgg ccttgccaca   1020

accgtgagaa ggccaagggc ctgggcaagt acatctgcca gcggtgccac ctggtcatcg   1080

acgagcagcc cctcatgttc aggagcgacg cctaccaccc tgaccacttc aactgcaccc   1140

actgtgggaa ggagctgaca gccgaggccc gcgagctgaa gggtgagctc tactgcctgc   1200

cctgccatga caagatgggc gtccccatct gcggggcctg ccgccggccc atcgagggcc   1260

gagtggtcaa cgcgctgggc aagcagtggc acgtggagca ctttgtctgt gccaagtgtg   1320

agaagccatt cctggggcac cggcactatg agaagaaggg cctggcctac tgcgagactc   1380

actacaacca ggtgagcccg gtgcagaacc ttcagggatg cgggtctgga ggggtggcca   1440

ggagagctgc cgtgagcaag ggaggctgtg ggcaccccct caggagctct gccaggtgct   1500

gagcccaggc ctgcaccctc agccctggct cctggcctgg ggtctcgaga cctgggcagc   1560

tctcttcagt ctcagtgtct tcctttgaag aatgttctgg ggctggtgtg aggtcccggg   1620

cacatggggc tgacagtgcc agcaaccccc tccctccctt gctctggtac agaaggcagg   1680

gggcgctggt gggatgcagt caccacctgg gcccacctcc ttgcaggaca gcagtggcca   1740

gagcagaggg gccttctggg gagcaacgcc ccagcctgtt gtccttcccg gaagggtggt   1800

tctcatgggt tgccgtgccc tcaacccagc cttgcagctg ggccctggga ggcagggcct   1860

gggagatgcc tgagaggggc cgtgttggag ggccaggctg gctgcatgat ggccctgggc   1920

tggggtgtga ctgcctgcag ctactctgac agcctgctcg gcccacagct cttcggggac   1980

gtctgctaca actgcagcca tgtgattgaa ggcgatgtgg tgtcggccct caacaaggcc   2040

tggtgtgtga gctgcttctc ctgctccacc tgcaacagca agctcaccct gaagaacaag   2100

tttgtggagt tcgacatgaa gcccgtgtgt aagaggtgct acgagaagtt cccgctggag   2160

ctgaagaagc ggctgaagaa gctgtcggag ctgacctccc gcaaggccca gcccaaggcc   2220

acagacctca actctgcctg aaggccctct tgcgcagctg cctctcggcc cctccgcctt   2280

ctcccctcct gctgtccatg cttggccccc tcgtccccat ccacctgtgc cctccgcatc   2340

ttaccctccc tttctctttc ctcattgcct tctcccttcc tgttccctca tctctgcctt   2400

ccccatgtct ctcctctcct tggccgtggc ttctgtctgt gaggaggcag gagctgggga   2460

gtgggagcct atgaccccac gtctgacagc catgtccacc tgtgcccaca gcttccgccc   2520

acagacctcc agggacagga gcaaattgca ccacagctcc ccgcctggcc tggccctccc   2580

caggcggctc agtggctcat gctgtcctgt gagagcccct gccccagagc ggccccacta   2640

agcgcatgtg gctcctgggc tacccacagc cagggcagcc tgctggagcc acagggccag   2700

ggccatgcag atggaggcct ctgggagcca cctccaatcc ctcaccactc actcaaccag   2760

tggcacagtg tccttgtgcc cacactgagc cagcaagtcc tgctgtccac acccacaagc   2820

tacctggagg gacaggaccc acctccatcc ttcggaaggc cttcctggaa tcccaccttg   2880

gcctccgccc tcggttccgc cccgcccctc tccccccgac cttggggctt gtgtcgagcc   2940

cttgggtggg gccaggagga ggtgatggcg tcagaggagg tgtggtcaga ggtgacttgt   3000

tcccacctcc agggaggacg cttcgtcttc ggccagcgca gacctggtgt ttgtttgttg   3060

ggctcacgct tgcacaatga aggcttgttc acacaaccac a                       3101


<210>  8290
<211>  311
<212>  PRT
<213>  Homosapiens

<400>  8290

Met Ala Ala Arg Leu Gly Ala Leu Ala Ala Ser Gly Leu Tyr Arg Arg 
1               5                   10                  15      


Arg Gln His Arg Gln Ser Pro Pro Pro Ala Thr Gly Asn Met Ser Asp 
            20                  25                  30          


Ala Leu Ala Asn Ala Val Cys Gln Arg Cys Gln Ala Arg Phe Ser Pro 
        35                  40                  45              


Ala Glu Arg Ile Val Asn Ser Asn Gly Glu Leu Tyr His Glu His Cys 
    50                  55                  60                  


Phe Val Cys Ala Gln Cys Phe Arg Pro Phe Pro Glu Gly Leu Phe Tyr 
65                  70                  75                  80  


Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln Met Leu Phe 
                85                  90                  95      


Ala Pro Cys Cys Gly Ser Cys Gly Glu Phe Ile Ile Gly Arg Val Ile 
            100                 105                 110         


Lys Ala Met Asn Asn Asn Trp His Pro Gly Cys Phe Arg Cys Glu Leu 
        115                 120                 125             


Cys Asp Val Glu Leu Ala Asp Leu Gly Phe Val Lys Asn Ala Gly Arg 
    130                 135                 140                 


His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Lys Gly Leu Gly 
145                 150                 155                 160 


Lys Tyr Ile Cys Gln Arg Cys His Leu Val Ile Asp Glu Gln Pro Leu 
                165                 170                 175     


Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn Cys Thr His 
            180                 185                 190         


Cys Gly Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys Gly Glu Leu 
        195                 200                 205             


Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile Cys Gly Ala 
    210                 215                 220                 


Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu Gly Lys Gln 
225                 230                 235                 240 


Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe Leu 
                245                 250                 255     


Gly His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys Glu Thr His 
            260                 265                 270         


Tyr Asn Gln Val Ser Pro Val Gln Asn Leu Gln Gly Cys Gly Ser Gly 
        275                 280                 285             


Gly Val Ala Arg Arg Ala Ala Val Ser Lys Gly Gly Cys Gly His Pro 
    290                 295                 300                 


Leu Arg Ser Ser Ala Arg Cys 
305                 310     


<210>  8291
<211>  2507
<212>  DNA
<213>  Homosapiens

<400>  8291
aagtgcatga ctcaggactg ggtgggaggg ggctgtccct gaggccctgg tctcccccag     60

ccaagtcctg gcagggggat gctgttcttc aggatcccat gacctggggc tcttggggag    120

ccccagcccg gagagtgacc tgtggctttg ctggggaaag gggcttggag ggtacagggc    180

agtgtccagg attgcagtct caaatccgag gcccacaggg gagctgcctc tgtgatcgcc    240

attaaggctg tggcctgggg tctcagggca gcccaggaac caaaaatagc ctgtaacttg    300

tcactttgta agtcctgccc tccagacaca cttccctttc ttctccccaa gcctctcttc    360

ccagttagct cccctgactt ggagtcacct ctaagccttg gcccaggccc ctctgcagtg    420

agatggaggg actcatcccc cggagagtgg catctgcagg cccactggct gcctgtggtc    480

accccctagg gttctagcgg ggctgcctcc cattttcctc agagcatccc tgccagctgg    540

ctggttctca ctctcctgtt ttctaggaaa agaaagtggg gagagacagg aacagggtcc    600

ggagcagccc cagcagcagc attgaggtgg agcaatatgt cggacgcctt ggccaacgcc    660

gtgtgccagc gctgccaggc ccgcttctcc cccgccgagc gcattgtcaa cagcaatggg    720

gagctgtacc atgagcactg cttcgtgtgt gcccagtgct tccggccctt ccccgagggg    780

ctcttctatg agtttgaagg ccggaagtac tgcgaacacg acttccaaat gctgtttgct    840

ccgtgctgtg gatcctgcgg tgagttcatc attggccgcg tcatcaaggc catgaacaac    900

aactggcacc cgggctgctt ccgctgcgag ctgtgtgatg tggagctggc tgacctgggc    960

tttgtgaaga atgccggcag gcatctctgc cggccttgcc acaaccgtga gaaggccaag   1020

ggcctgggca agtacatctg ccagcggtgc cacctggtca tcgacgagca gcccctcatg   1080

ttcaggagcg acgcctacca ccctgaccac ttcaactgca cccactgtgg gaaggagctg   1140

acagccgagg cccgcgagct gaagggtgag ctctactgcc tgccctgcca tgacaagatg   1200

ggcgtcccca tctgcggggc ctgccgccgg cccatcgagg gccgagtggt caacgcgctg   1260

ggcaagcagt ggcacgtgga gcactttgtc tgtgccaagt gtgagaagcc attcctgggg   1320

caccggcact atgagaagaa gggcctggcc tactgcgaga ctcactacaa ccagctcttc   1380

ggggacgtct gctacaactg cagccatgtg attgaaggcg atgtggtgtc ggccctcaac   1440

aaggcctggt gtgtgagctg cttctcctgc tccacctgca acagcaagct caccctgaag   1500

aacaagtttg tggagttcga catgaagccc gtgtgtaaga ggtgctacga gaagttcccg   1560

ctggagctga agaagcggct gaagaagctg tcggagctga cctcccgcaa ggcccagccc   1620

aaggccacag acctcaactc tgcctgaagg ccctcttgcg cagctgcctc tcggcccctc   1680

cgccttctcc cctcctgctg tccatgcttg gccccctcgt ccccatccac ctgtgccctc   1740

cgcatcttac cctccctttc tctttcctca ttgccttctc ccttcctgtt ccctcatctc   1800

tgccttcccc atgtctctcc tctccttggc cgtggcttct gtctgtgagg aggcaggagc   1860

tggggagtgg gagcctatga ccccacgtct gacagccatg tccacctgtg cccacagctt   1920

ccgcccacag acctccaggg acaggagcaa attgcaccac agctccccgc ctggcctggc   1980

cctccccagg cggctcagtg gctcatgctg tcctgtgaga gcccctgccc cagagcggcc   2040

ccactaagcg catgtggctc ctgggctacc cacagccagg gcagcctgct ggagccacag   2100

ggccagggcc atgcagatgg aggcctctgg gagccacctc caatccctca ccactcactc   2160

aaccagtggc acagtgtcct tgtgcccaca ctgagccagc aagtcctgct gtccacaccc   2220

acaagctacc tggagggaca ggacccacct ccatccttcg gaaggccttc ctggaatccc   2280

accttggcct ccgccctcgg ttccgccccg cccctctccc cccgaccttg gggcttgtgt   2340

cgagcccttg ggtggggcca ggaggaggtg atggcgtcag aggaggtgtg gtcagaggtg   2400

acttgttccc acctccaggg aggacgcttc gtcttcggcc agcgcagacc tggtgtttgt   2460

ttgttgggct cacgcttgca caatgaaggc ttgttcacac aaccaca                 2507


<210>  8292
<211>  336
<212>  PRT
<213>  Homosapiens

<400>  8292

Met Ser Asp Ala Leu Ala Asn Ala Val Cys Gln Arg Cys Gln Ala Arg 
1               5                   10                  15      


Phe Ser Pro Ala Glu Arg Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu His Cys Phe Val Cys Ala Gln Cys Phe Arg Pro Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
    50                  55                  60                  


Met Leu Phe Ala Pro Cys Cys Gly Ser Cys Gly Glu Phe Ile Ile Gly 
65                  70                  75                  80  


Arg Val Ile Lys Ala Met Asn Asn Asn Trp His Pro Gly Cys Phe Arg 
                85                  90                  95      


Cys Glu Leu Cys Asp Val Glu Leu Ala Asp Leu Gly Phe Val Lys Asn 
            100                 105                 110         


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Lys 
        115                 120                 125             


Gly Leu Gly Lys Tyr Ile Cys Gln Arg Cys His Leu Val Ile Asp Glu 
    130                 135                 140                 


Gln Pro Leu Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn 
145                 150                 155                 160 


Cys Thr His Cys Gly Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys 
                165                 170                 175     


Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile 
            180                 185                 190         


Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu 
        195                 200                 205             


Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys 
    210                 215                 220                 


Pro Phe Leu Gly His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys 
225                 230                 235                 240 


Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser 
                245                 250                 255     


His Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys 
            260                 265                 270         


Val Ser Cys Phe Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys 
        275                 280                 285             


Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr 
    290                 295                 300                 


Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu 
305                 310                 315                 320 


Leu Thr Ser Arg Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
                325                 330                 335     


<210>  8293
<211>  1533
<212>  DNA
<213>  Homosapiens

<400>  8293
agagggagac ccgcggcaac cccggcaacc cagggctcgg cgtcgctgcc accatgacgg     60

gaagcaatat gtcggacgcc ttggccaacg ccgtgtgcca gcgctgccag gcccgcttct    120

cccccgccga gcgcattgtc aacagcaatg gggagctgta ccatgagcac tgcttcgtgt    180

gtgcccagtg cttccggccc ttccccgagg ggctcttcta tgagtttgaa ggccggaagt    240

actgcgaaca cgacttccaa atgctgtttg ctccgtgctg tggatcctgc ggtgagttca    300

tcattggccg cgtcatcaag gccattgtga gaagccattc ctggggcacc ggcactatga    360

gaagaagggc ctggcctact gcgagactca ctacaaccag ctcttcgggg acgtctgcta    420

caactgcagc catgtgattg aaggcgatgt ggtgtcggcc ctcaacaagg cctggtgtgt    480

gagctgcttc tcctgctcca cctgcaacag caagctcacc ctgaagaaca agtttgtgga    540

gttcgacatg aagcccgtgt gtaagaggtg ctacgagaag ttcccgctgg agctgaagaa    600

gcggctgaag aagctgtcgg agctgacctc ccgcaaggcc cagcccaagg ccacagacct    660

caactctgcc tgaaggccct cttgcgcagc tgcctctcgg cccctccgcc ttctcccctc    720

ctgctgtcca tgcttggccc cctcgtcccc atccacctgt gccctccgca tcttaccctc    780

cctttctctt tcctcattgc cttctccctt cctgttccct catctctgcc ttccccatgt    840

ctctcctctc cttggccgtg gcttctgtct gtgaggaggc aggagctggg gagtgggagc    900

ctatgacccc acgtctgaca gccatgtcca cctgtgccca cagcttccgc ccacagacct    960

ccagggacag gagcaaattg caccacagct ccccgcctgg cctggccctc cccaggcggc   1020

tcagtggctc atgctgtcct gtgagagccc ctgccccaga gcggccccac taagcgcatg   1080

tggctcctgg gctacccaca gccagggcag cctgctggag ccacagggcc agggccatgc   1140

agatggaggc ctctgggagc cacctccaat ccctcaccac tcactcaacc agtggcacag   1200

tgtccttgtg cccacactga gccagcaagt cctgctgtcc acacccacaa gctacctgga   1260

gggacaggac ccacctccat ccttcggaag gccttcctgg aatcccacct tggcctccgc   1320

cctcggttcc gccccgcccc tctccccccg accttggggc ttgtgtcgag cccttgggtg   1380

gggccaggag gaggtgatgg cgtcagagga ggtgtggtca gaggtgactt gttcccacct   1440

ccagggagga cgcttcgtct tcggccagcg cagacctggt gtttgtttgt tgggctcacg   1500

cttgcacaat gaaggcttgt tcacacaacc aca                                1533


<210>  8294
<211>  127
<212>  PRT
<213>  Homosapiens

<400>  8294

Met Thr Gly Ser Asn Met Ser Asp Ala Leu Ala Asn Ala Val Cys Gln 
1               5                   10                  15      


Arg Cys Gln Ala Arg Phe Ser Pro Ala Glu Arg Ile Val Asn Ser Asn 
            20                  25                  30          


Gly Glu Leu Tyr His Glu His Cys Phe Val Cys Ala Gln Cys Phe Arg 
        35                  40                  45              


Pro Phe Pro Glu Gly Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys 
    50                  55                  60                  


Glu His Asp Phe Gln Met Leu Phe Ala Pro Cys Cys Gly Ser Cys Gly 
65                  70                  75                  80  


Glu Phe Ile Ile Gly Arg Val Ile Lys Ala Ile Val Arg Ser His Ser 
                85                  90                  95      


Trp Gly Thr Gly Thr Met Arg Arg Arg Ala Trp Pro Thr Ala Arg Leu 
            100                 105                 110         


Thr Thr Thr Ser Ser Ser Gly Thr Ser Ala Thr Thr Ala Ala Met 
        115                 120                 125         


<210>  8295
<211>  1981
<212>  DNA
<213>  Homosapiens

<400>  8295
cccgggctgg cgggcgggcg ctcggctggc ggctgcagca gcagagggag acccgcggca     60

accccggcaa cccagggctc ggcgtcgctg ccaccatgac gggaagcaat atgtcggacg    120

ccttggccaa cgccgtgtgc cagcgctgcc aggcccgctt ctcccccgcc gagcgcattg    180

tcaacagcaa tggggagctg taccatgagc actgcttcgt gtgtgcccag tgcttccggc    240

ccttccccga ggggctcttc tatgagtttg aaggccggaa gtactgcgaa cacgacttcc    300

aaatgctgtt tgctccgtgc tgtggatcct gcggtgagtt catcattggc cgcgtcatca    360

aggccatgaa caacaactgg cacccgggct gcttccgctg cgagctgtgt gatgtggagc    420

tggctgacct gggctttgtg aagaatgccg gcaggcatct ctgccggcct tgccacaacc    480

gtgagaaggc caagggcctg ggcaagtaca tctgccagcg gtgccacctg gtcatcgacg    540

agcagcccct catgttcagg agcgacgcct accaccctga ccacttcaac tgcacccact    600

gtgggaagga gctgacagcc gaggcccgcg agctgaaggg tgagctctac tgcctgccct    660

gccatgacaa gatgggcgtc cccatctgcg gggcctgccg ccggcccatc gagggccgag    720

tggtcaacgc gctgggcaag cagtggcacg tggagcactt tgtctgtgcc aagtgtgaga    780

agccattcct ggggcaccgg cactatgaga agaagggcct ggcctactgc gagactcact    840

acaaccagct cttcggggac gtctgctaca actgcagcca tgtgattgaa ggcgatgtgg    900

tgtcggccct caacaaggcc tggtgtgtga gctgcttctc ctgctccacc tgcaacagca    960

agctcaccct gaagaacaag tttgtggagt tcgacatgaa gcccgtgtgt aagaggtgct   1020

acgagaagtt cccgctggag ctgaagaagc ggctgaagaa gctgtcggag ctgacctccc   1080

gcaaggccca gcccaaggcc acagacctca actctgcctg aaggccctct tgcgcagctg   1140

cctctcggcc cctccgcctt ctcccctcct gctgtccatg cttggccccc tcgtccccat   1200

ccacctgtgc cctccgcatc ttaccctccc tttctctttc ctcattgcct tctcccttcc   1260

tgttccctca tctctgcctt ccccatgtct ctcctctcct tggccgtggc ttctgtctgt   1320

gaggaggcag gagctgggga gtgggagcct atgaccccac gtctgacagc catgtccacc   1380

tgtgcccaca gcttccgccc acagacctcc agggacagga gcaaattgca ccacagctcc   1440

ccgcctggcc tggccctccc caggcggctc agtggctcat gctgtcctgt gagagcccct   1500

gccccagagc ggccccacta agcgcatgtg gctcctgggc tacccacagc cagggcagcc   1560

tgctggagcc acagggccag ggccatgcag atggaggcct ctgggagcca cctccaatcc   1620

ctcaccactc actcaaccag tggcacagtg tccttgtgcc cacactgagc cagcaagtcc   1680

tgctgtccac acccacaagc tacctggagg gacaggaccc acctccatcc ttcggaaggc   1740

cttcctggaa tcccaccttg gcctccgccc tcggttccgc cccgcccctc tccccccgac   1800

cttggggctt gtgtcgagcc cttgggtggg gccaggagga ggtgatggcg tcagaggagg   1860

tgtggtcaga ggtgacttgt tcccacctcc agggaggacg cttcgtcttc ggccagcgca   1920

gacctggtgt ttgtttgttg ggctcacgct tgcacaatga aggcttgttc acacaaccac   1980

a                                                                   1981


<210>  8296
<211>  341
<212>  PRT
<213>  Homosapiens

<400>  8296

Met Thr Gly Ser Asn Met Ser Asp Ala Leu Ala Asn Ala Val Cys Gln 
1               5                   10                  15      


Arg Cys Gln Ala Arg Phe Ser Pro Ala Glu Arg Ile Val Asn Ser Asn 
            20                  25                  30          


Gly Glu Leu Tyr His Glu His Cys Phe Val Cys Ala Gln Cys Phe Arg 
        35                  40                  45              


Pro Phe Pro Glu Gly Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys 
    50                  55                  60                  


Glu His Asp Phe Gln Met Leu Phe Ala Pro Cys Cys Gly Ser Cys Gly 
65                  70                  75                  80  


Glu Phe Ile Ile Gly Arg Val Ile Lys Ala Met Asn Asn Asn Trp His 
                85                  90                  95      


Pro Gly Cys Phe Arg Cys Glu Leu Cys Asp Val Glu Leu Ala Asp Leu 
            100                 105                 110         


Gly Phe Val Lys Asn Ala Gly Arg His Leu Cys Arg Pro Cys His Asn 
        115                 120                 125             


Arg Glu Lys Ala Lys Gly Leu Gly Lys Tyr Ile Cys Gln Arg Cys His 
    130                 135                 140                 


Leu Val Ile Asp Glu Gln Pro Leu Met Phe Arg Ser Asp Ala Tyr His 
145                 150                 155                 160 


Pro Asp His Phe Asn Cys Thr His Cys Gly Lys Glu Leu Thr Ala Glu 
                165                 170                 175     


Ala Arg Glu Leu Lys Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys 
            180                 185                 190         


Met Gly Val Pro Ile Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg 
        195                 200                 205             


Val Val Asn Ala Leu Gly Lys Gln Trp His Val Glu His Phe Val Cys 
    210                 215                 220                 


Ala Lys Cys Glu Lys Pro Phe Leu Gly His Arg His Tyr Glu Lys Lys 
225                 230                 235                 240 


Gly Leu Ala Tyr Cys Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val 
                245                 250                 255     


Cys Tyr Asn Cys Ser His Val Ile Glu Gly Asp Val Val Ser Ala Leu 
            260                 265                 270         


Asn Lys Ala Trp Cys Val Ser Cys Phe Ser Cys Ser Thr Cys Asn Ser 
        275                 280                 285             


Lys Leu Thr Leu Lys Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val 
    290                 295                 300                 


Cys Lys Arg Cys Tyr Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu 
305                 310                 315                 320 


Lys Lys Leu Ser Glu Leu Thr Ser Arg Lys Ala Gln Pro Lys Ala Thr 
                325                 330                 335     


Asp Leu Asn Ser Ala 
            340     


<210>  8297
<211>  2562
<212>  DNA
<213>  Homosapiens

<400>  8297
aagaaatatc tttcgccaag ttagggcgat ggcccgcaac gggggatgaa atcggaattt     60

cccggggaaa gcagctttgc gactgaagag ggacgcctct cggctttagc ctccctgggg    120

gcgggactgc gtggactcgg cggtcccggg tgcctcggga gggagtcagt gcccagatcc    180

gcggtgggaa ctccgggcta ggaaagcccg ggagggaggt ggtctcagca tcgcccccac    240

ctatactccc gcaacctccc accgtcacct ccccaacacc cccaccaccc tcagccttga    300

cctccccatc ccaccccgcc ccgcgggccc caccctgcca cccccgccca cccctctcgc    360

gggcggagcg gctcttggcc ttttttgggc gtctccctgc tccgcggccc gggctggcgg    420

gcgggcgctc ggctggcggc tgcagcagca gagggagacc cgcggcaacc ccggcaaccc    480

agggctcggc gtcgctgcca ccatgacggg aagatgaggt caccagaggc cacagaggct    540

gagccactca ggaggccagt cacaggtcca ccagtgtccg gccagtgttt gtccctgcag    600

ccctttctgg aacctagctg ggaaaagaaa gtggggagag acaggaacag ggtccggagc    660

agccccagca gcagcattga ggtggagcaa tatgtcggac gccttggcca acgccgtgtg    720

ccagcgctgc caggcccgct tctcccccgc cgagcgcatt gtcaacagca atggggagct    780

gtaccatgag cactgcttcg tgtgtgccca gtgcttccgg cccttccccg aggggctctt    840

ctatgagttt gaaggccgga agtactgcga acacgacttc caaatgctgt ttgctccgtg    900

ctgtggatcc tgcggtgagt tcatcattgg ccgcgtcatc aaggccatga acaacaactg    960

gcacccgggc tgcttccgct gcgagctgtg tgatgtggag ctggctgacc tgggctttgt   1020

gaagaatgcc ggcaggcatc tctgccggcc ttgccacaac cgtgagaagg ccaagggcct   1080

gggcaagtac atctgccagc ggtgccacct ggtcatcgac gagcagcccc tcatgttcag   1140

gagcgacgcc taccaccctg accacttcaa ctgcacccac tgtgggaagg agctgacagc   1200

cgaggcccgc gagctgaagg gtgagctcta ctgcctgccc tgccatgaca agatgggcgt   1260

ccccatctgc ggggcctgcc gccggcccat cgagggccga gtggtcaacg cgctgggcaa   1320

gcagtggcac gtggagcact ttgtctgtgc caagtgtgag aagccattcc tggggcaccg   1380

gcactatgag aagaagggcc tggcctactg cgagactcac tacaaccagc tcttcgggga   1440

cgtctgctac aactgcagcc atgtgattga aggcgatgtg gtgtcggccc tcaacaaggc   1500

ctggtgtgtg agctgcttct cctgctccac ctgcaacagc aagctcaccc tgaagaacaa   1560

gtttgtggag ttcgacatga agcccgtgtg taagaggtgc tacgagaagt tcccgctgga   1620

gctgaagaag cggctgaaga agctgtcgga gctgacctcc cgcaaggccc agcccaaggc   1680

cacagacctc aactctgcct gaaggccctc ttgcgcagct gcctctcggc ccctccgcct   1740

tctcccctcc tgctgtccat gcttggcccc ctcgtcccca tccacctgtg ccctccgcat   1800

cttaccctcc ctttctcttt cctcattgcc ttctcccttc ctgttccctc atctctgcct   1860

tccccatgtc tctcctctcc ttggccgtgg cttctgtctg tgaggaggca ggagctgggg   1920

agtgggagcc tatgacccca cgtctgacag ccatgtccac ctgtgcccac agcttccgcc   1980

cacagacctc cagggacagg agcaaattgc accacagctc cccgcctggc ctggccctcc   2040

ccaggcggct cagtggctca tgctgtcctg tgagagcccc tgccccagag cggccccact   2100

aagcgcatgt ggctcctggg ctacccacag ccagggcagc ctgctggagc cacagggcca   2160

gggccatgca gatggaggcc tctgggagcc acctccaatc cctcaccact cactcaacca   2220

gtggcacagt gtccttgtgc ccacactgag ccagcaagtc ctgctgtcca cacccacaag   2280

ctacctggag ggacaggacc cacctccatc cttcggaagg ccttcctgga atcccacctt   2340

ggcctccgcc ctcggttccg ccccgcccct ctccccccga ccttggggct tgtgtcgagc   2400

ccttgggtgg ggccaggagg aggtgatggc gtcagaggag gtgtggtcag aggtgacttg   2460

ttcccacctc cagggaggac gcttcgtctt cggccagcgc agacctggtg tttgtttgtt   2520

gggctcacgc ttgcacaatg aaggcttgtt cacacaacca ca                      2562


<210>  8298
<211>  336
<212>  PRT
<213>  Homosapiens

<400>  8298

Met Ser Asp Ala Leu Ala Asn Ala Val Cys Gln Arg Cys Gln Ala Arg 
1               5                   10                  15      


Phe Ser Pro Ala Glu Arg Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu His Cys Phe Val Cys Ala Gln Cys Phe Arg Pro Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
    50                  55                  60                  


Met Leu Phe Ala Pro Cys Cys Gly Ser Cys Gly Glu Phe Ile Ile Gly 
65                  70                  75                  80  


Arg Val Ile Lys Ala Met Asn Asn Asn Trp His Pro Gly Cys Phe Arg 
                85                  90                  95      


Cys Glu Leu Cys Asp Val Glu Leu Ala Asp Leu Gly Phe Val Lys Asn 
            100                 105                 110         


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Lys 
        115                 120                 125             


Gly Leu Gly Lys Tyr Ile Cys Gln Arg Cys His Leu Val Ile Asp Glu 
    130                 135                 140                 


Gln Pro Leu Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn 
145                 150                 155                 160 


Cys Thr His Cys Gly Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys 
                165                 170                 175     


Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile 
            180                 185                 190         


Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu 
        195                 200                 205             


Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys 
    210                 215                 220                 


Pro Phe Leu Gly His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys 
225                 230                 235                 240 


Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser 
                245                 250                 255     


His Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys 
            260                 265                 270         


Val Ser Cys Phe Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys 
        275                 280                 285             


Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr 
    290                 295                 300                 


Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu 
305                 310                 315                 320 


Leu Thr Ser Arg Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
                325                 330                 335     


<210>  8299
<211>  2019
<212>  DNA
<213>  Homosapiens

<400>  8299
ggccggacac tcctggcggc tgctcagtct tgcacgtggc tgtgccaagc gggccaggca     60

gctgctattt ccctcagaga agttgctggc ggcgctcagg gaaggaagca cccgaggagg    120

cggagcggca tctcagccac agagcaatat gtcggacgcc ttggccaacg ccgtgtgcca    180

gcgctgccag gcccgcttct cccccgccga gcgcattgtc aacagcaatg gggagctgta    240

ccatgagcac tgcttcgtgt gtgcccagtg cttccggccc ttccccgagg ggctcttcta    300

tgagtttgaa ggccggaagt actgcgaaca cgacttccaa atgctgtttg ctccgtgctg    360

tggatcctgc ggtgagttca tcattggccg cgtcatcaag gccatgaaca acaactggca    420

cccgggctgc ttccgctgcg agctgtgtga tgtggagctg gctgacctgg gctttgtgaa    480

gaatgccggc aggcatctct gccggccttg ccacaaccgt gagaaggcca agggcctggg    540

caagtacatc tgccagcggt gccacctggt catcgacgag cagcccctca tgttcaggag    600

cgacgcctac caccctgacc acttcaactg cacccactgt gggaaggagc tgacagccga    660

ggcccgcgag ctgaagggtg agctctactg cctgccctgc catgacaaga tgggcgtccc    720

catctgcggg gcctgccgcc ggcccatcga gggccgagtg gtcaacgcgc tgggcaagca    780

gtggcacgtg gagcactttg tctgtgccaa gtgtgagaag ccattcctgg ggcaccggca    840

ctatgagaag aagggcctgg cctactgcga gactcactac aaccagctct tcggggacgt    900

ctgctacaac tgcagccatg tgattgaagg cgatgtggtg tcggccctca acaaggcctg    960

gtgtgtgagc tgcttctcct gctccacctg caacagcaag ctcaccctga agaacaagtt   1020

tgtggagttc gacatgaagc ccgtgtgtaa gaggtgctac gagaagttcc cgctggagct   1080

gaagaagcgg ctgaagaagc tgtcggagct gacctcccgc aaggcccagc ccaaggccac   1140

agacctcaac tctgcctgaa ggccctcttg cgcagctgcc tctcggcccc tccgccttct   1200

cccctcctgc tgtccatgct tggccccctc gtccccatcc acctgtgccc tccgcatctt   1260

accctccctt tctctttcct cattgccttc tcccttcctg ttccctcatc tctgccttcc   1320

ccatgtctct cctctccttg gccgtggctt ctgtctgtga ggaggcagga gctggggagt   1380

gggagcctat gaccccacgt ctgacagcca tgtccacctg tgcccacagc ttccgcccac   1440

agacctccag ggacaggagc aaattgcacc acagctcccc gcctggcctg gccctcccca   1500

ggcggctcag tggctcatgc tgtcctgtga gagcccctgc cccagagcgg ccccactaag   1560

cgcatgtggc tcctgggcta cccacagcca gggcagcctg ctggagccac agggccaggg   1620

ccatgcagat ggaggcctct gggagccacc tccaatccct caccactcac tcaaccagtg   1680

gcacagtgtc cttgtgccca cactgagcca gcaagtcctg ctgtccacac ccacaagcta   1740

cctggaggga caggacccac ctccatcctt cggaaggcct tcctggaatc ccaccttggc   1800

ctccgccctc ggttccgccc cgcccctctc cccccgacct tggggcttgt gtcgagccct   1860

tgggtggggc caggaggagg tgatggcgtc agaggaggtg tggtcagagg tgacttgttc   1920

ccacctccag ggaggacgct tcgtcttcgg ccagcgcaga cctggtgttt gtttgttggg   1980

ctcacgcttg cacaatgaag gcttgttcac acaaccaca                          2019


<210>  8300
<211>  336
<212>  PRT
<213>  Homosapiens

<400>  8300

Met Ser Asp Ala Leu Ala Asn Ala Val Cys Gln Arg Cys Gln Ala Arg 
1               5                   10                  15      


Phe Ser Pro Ala Glu Arg Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu His Cys Phe Val Cys Ala Gln Cys Phe Arg Pro Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
    50                  55                  60                  


Met Leu Phe Ala Pro Cys Cys Gly Ser Cys Gly Glu Phe Ile Ile Gly 
65                  70                  75                  80  


Arg Val Ile Lys Ala Met Asn Asn Asn Trp His Pro Gly Cys Phe Arg 
                85                  90                  95      


Cys Glu Leu Cys Asp Val Glu Leu Ala Asp Leu Gly Phe Val Lys Asn 
            100                 105                 110         


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Lys 
        115                 120                 125             


Gly Leu Gly Lys Tyr Ile Cys Gln Arg Cys His Leu Val Ile Asp Glu 
    130                 135                 140                 


Gln Pro Leu Met Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn 
145                 150                 155                 160 


Cys Thr His Cys Gly Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys 
                165                 170                 175     


Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile 
            180                 185                 190         


Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu 
        195                 200                 205             


Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys 
    210                 215                 220                 


Pro Phe Leu Gly His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys 
225                 230                 235                 240 


Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser 
                245                 250                 255     


His Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys 
            260                 265                 270         


Val Ser Cys Phe Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys 
        275                 280                 285             


Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr 
    290                 295                 300                 


Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu 
305                 310                 315                 320 


Leu Thr Ser Arg Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
                325                 330                 335     


<210>  8301
<211>  881
<212>  DNA
<213>  Homosapiens

<400>  8301
cgggcgggcg ctcggctggc ggctgcagca gcagagggag acccgcggca accccggcaa     60

cccagggctc ggcgtcgctg ccaccatgac gggaagcaat atgtcggacg ccttggccaa    120

cgccgtgtgc cagcgctgcc aggcccgctt ctcccccgcc gagcgcattg tcaacagcaa    180

tggggagctg taccatgagc actgcttcgt gtgtgcccag tgcttccggc ccttccccga    240

ggggctcttc tatgagtttg aaggccggaa gtactgcgaa cacgacttcc aaatgctgtt    300

tgctccgtgc tgtggatcct gcggtgagtt catcattggc cgcgtcatca aggccatgaa    360

caacaactgg cacccgggct gcttccgctg cgagctgtgt gatgtggagc tggctgacct    420

gggctttgtg aagaatgccg gcaggcatct ctgccggcct tgccacaacc gtgagaaggc    480

caagggcctg ggcaagtaca tctgccagcg gtgccacctg gtcatcgacg agcagcccct    540

catgttcagg agcgacgcct accaccctga ccacttcaac tgcacccact gtgggaagga    600

gctgacagcc gaggcccgcg agctgaaggg tgagctctac tgcctgccct gccatgacaa    660

gatgggcgtc cccatctgcg gggcctgccg ccggcccatc gagggccgag tggtcaacgc    720

gctgggcaag cagtggcacg tggagcactt tgtctgtgcc aagtgtgaga agccattcct    780

ggggcaccgg cactatgaga agaagggcct ggcctactgc gagactcact acaaccaggt    840

gagcccggtg cagaaccttc agggatgcgg gtctggaggg g                        881


<210>  8302
<211>  264
<212>  PRT
<213>  Homosapiens

<400>  8302

Met Thr Gly Ser Asn Met Ser Asp Ala Leu Ala Asn Ala Val Cys Gln 
1               5                   10                  15      


Arg Cys Gln Ala Arg Phe Ser Pro Ala Glu Arg Ile Val Asn Ser Asn 
            20                  25                  30          


Gly Glu Leu Tyr His Glu His Cys Phe Val Cys Ala Gln Cys Phe Arg 
        35                  40                  45              


Pro Phe Pro Glu Gly Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys 
    50                  55                  60                  


Glu His Asp Phe Gln Met Leu Phe Ala Pro Cys Cys Gly Ser Cys Gly 
65                  70                  75                  80  


Glu Phe Ile Ile Gly Arg Val Ile Lys Ala Met Asn Asn Asn Trp His 
                85                  90                  95      


Pro Gly Cys Phe Arg Cys Glu Leu Cys Asp Val Glu Leu Ala Asp Leu 
            100                 105                 110         


Gly Phe Val Lys Asn Ala Gly Arg His Leu Cys Arg Pro Cys His Asn 
        115                 120                 125             


Arg Glu Lys Ala Lys Gly Leu Gly Lys Tyr Ile Cys Gln Arg Cys His 
    130                 135                 140                 


Leu Val Ile Asp Glu Gln Pro Leu Met Phe Arg Ser Asp Ala Tyr His 
145                 150                 155                 160 


Pro Asp His Phe Asn Cys Thr His Cys Gly Lys Glu Leu Thr Ala Glu 
                165                 170                 175     


Ala Arg Glu Leu Lys Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys 
            180                 185                 190         


Met Gly Val Pro Ile Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg 
        195                 200                 205             


Val Val Asn Ala Leu Gly Lys Gln Trp His Val Glu His Phe Val Cys 
    210                 215                 220                 


Ala Lys Cys Glu Lys Pro Phe Leu Gly His Arg His Tyr Glu Lys Lys 
225                 230                 235                 240 


Gly Leu Ala Tyr Cys Glu Thr His Tyr Asn Gln Val Ser Pro Val Gln 
                245                 250                 255     


Asn Leu Gln Gly Cys Gly Ser Gly 
            260                 


<210>  8303
<211>  2185
<212>  DNA
<213>  Homosapiens

<400>  8303
gggctaggga cacactagaa tattcacgct ccggtggcag cagcagcagc agccagagga     60

gcagcccgac acaacaaggg acccctcagg aatgaagcag cctttcaggg ccagaggggc    120

tgtggtctcc cttcctctcc ttaaatagcc agcgttccac ccacagcggc aaggagcccc    180

ctgccaccac cgacacccac gggcggagat cacctgctgc cccgcagacc cctgtccctt    240

cctcccggac cagcagctag aggctctgac tccagccaaa gcatgaatgg ccttgaagtg    300

gctcccccag gtctgatcac caacttctcc ctggccacgg cagagcaatg tggccaggag    360

acgccactgg agaacatgct gttcgcctcc ttctaccttc tggattttat cctggcttta    420

gttggcaata ccctggctct gtggcttttc atccgagacc acaagtccgg gaccccggcc    480

aacgtgttcc tgatgcatct ggccgtggcc gacttgtcgt gcgtgctggt cctgcccacc    540

cgcctggtct accacttctc tgggaaccac tggccatttg gggaaatcgc atgccgtctc    600

accggcttcc tcttctacct caacatgtac gccagcatct acttcctcac ctgcatcagc    660

gccgaccgtt tcctggccat tgtgcacccg gtcaagtccc tcaagctccg caggcccctc    720

tacgcacacc tggcctgtgc cttcctgtgg gtggtggtgg ctgtggccat ggccccgctg    780

ctggtgagcc cacagaccgt gcagaccaac cacacggtgg tctgcctgca gctgtaccgg    840

gagaaggcct cccaccatgc cctggtgtcc ctggcagtgg ccttcacctt cccgttcatc    900

accacggtca cctgctacct gctgatcatc cgcagcctgc ggcagggcct gcgtgtggag    960

aagcgcctca agaccaaggc agtgcgcatg atcgccatag tgctggccat cttcctggtc   1020

tgcttcgtgc cctaccacgt caaccgctcc gtctacgtgc tgcactaccg cagccatggg   1080

gcctcctgcg ccacccagcg catcctggcc ctggcaaacc gcatcacctc ctgcctcacc   1140

agcctcaacg gggcactcga ccccatcatg tatttcttcg tggctgagaa gttccgccac   1200

gccctgtgca acttgctctg tggcaaaagg ctcaagggcc cgccccccag cttcgaaggg   1260

aaaaccaacg agagctcgct gagtgccaag tcagagctgt gagcgggggg cgccgtccag   1320

gccgagcgca gactgtttag gactcagcag acccagcaag aggcatctgc cctttcccca   1380

gccacctccc cagcaagcaa cctgaaatct cagcagatgc ccaccatttc tctagatcgc   1440

ctagtctcaa cccataaaaa ggaagaactg acaaagggga tccatcggcc acccctctgc   1500

aggggcttgt gatggctaca atggctccta gacactcaac gacttcatct gtggcaggga   1560

gagaggaggc cggaagaaca acccctgaac aatggaggcc tttctttccc gctaggctcc   1620

cagcctcctt cccgctacag aatcgctcat cggcgaggct cagcagaaag accctgaagg   1680

caggctgcaa atgacccaga agagggacct gggagtcctg gtggggacgg ggagggagtc   1740

tcaatactcc tttgcagtgc aaggtactct gagtcccctc tgtagtgcct ctgccagaca   1800

cacactgcct gagttgaaga gacacaggcc acacatttca ggctggttgc cagcggacgt   1860

cagcactcac ggcctgcagg gactcagcac agctctggat tctggatctc tcctgctgta   1920

accccacgca caagcctgca acccccagag ctctttgaca ggctcccagg cctcccagtc   1980

ctggacaagc atgtgcagtc acgggagctc agctcaggcc agggctgggc tgtgcacctg   2040

cctcccactg acccagaccc acttcctcca gagaggcctc tctccgcctg agctatttcc   2100

cttgctagtg tgcagatatt tccctaacat gtcctttttt gtatttgttt gtacggacca   2160

taaatataac tgtagcttta agact                                         2185


<210>  8304
<211>  339
<212>  PRT
<213>  Homosapiens

<400>  8304

Met Asn Gly Leu Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser 
1               5                   10                  15      


Leu Ala Thr Ala Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met 
            20                  25                  30          


Leu Phe Ala Ser Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly 
        35                  40                  45              


Asn Thr Leu Ala Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr 
    50                  55                  60                  


Pro Ala Asn Val Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys 
65                  70                  75                  80  


Val Leu Val Leu Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His 
                85                  90                  95      


Trp Pro Phe Gly Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr 
            100                 105                 110         


Leu Asn Met Tyr Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp 
        115                 120                 125             


Arg Phe Leu Ala Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg 
    130                 135                 140                 


Pro Leu Tyr Ala His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala 
145                 150                 155                 160 


Val Ala Met Ala Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn 
                165                 170                 175     


His Thr Val Val Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His 
            180                 185                 190         


Ala Leu Val Ser Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr 
        195                 200                 205             


Val Thr Cys Tyr Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg 
    210                 215                 220                 


Val Glu Lys Arg Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val 
225                 230                 235                 240 


Leu Ala Ile Phe Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser 
                245                 250                 255     


Val Tyr Val Leu His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln 
            260                 265                 270         


Arg Ile Leu Ala Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu 
        275                 280                 285             


Asn Gly Ala Leu Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe 
    290                 295                 300                 


Arg His Ala Leu Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro 
305                 310                 315                 320 


Pro Pro Ser Phe Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys 
                325                 330                 335     


Ser Glu Leu 
            


<210>  8305
<211>  2325
<212>  DNA
<213>  Homosapiens

<400>  8305
gggctaggga cacactagaa tattcacgct ccggtggcag cagcagcagc agccagagga     60

gcagcccgac acaacaaggg acccctcagg aatgaagcag cctttcaggg ccagaggggc    120

tgtggtctcc cttcctctcc ttaaatagcc agcgttccac ccacagcggc aaggagcccc    180

ctgccaccac cgacacccac gggcggagat cacctgctgc cccgcagacc cctgtccctt    240

cctcccggac cagcagctag aggctctgac tccagccaaa gcatgaatgg ccttgaagtg    300

gctcccccag gtctgatcac caacttctcc ctggccacgg cagagcaatg tggccaggag    360

acgccactgg agaacatgct gttcgcctcc ttctaccttc tggattttat cctggcttta    420

gttggcaata ccctggctct gtggcttttc atccgagacc acaagtccgg gaccccggcc    480

aacgtgttcc tgatgcatct ggccgtggcc gacttgtcgt gcgtgctggt cctgcccacc    540

cgcctggtct accacttctc tgggaaccac tggccatttg gggaaatcgc atgccgtctc    600

accggcttcc tcttctacct caacatgtac gccagcatct acttcctcac ctgcatcagc    660

gccgaccgtt tcctggccat tgtgcacccg gtcaagtccc tcaagctccg caggcccctc    720

tacgcacacc tggcctgtgc cttcctgtgg gtggtggtgg ctgtggccat ggccccgctg    780

ctggtgagcc cacagaccgt gcagaccaac cacacggtgg tctgcctgca gctgtaccgg    840

gagaaggcct cccaccatgc cctggtgtcc ctggcagtgg ccttcacctt cccgttcatc    900

accacggtca cctgctacct gctgatcatc cgcagcctgc ggcagggcct gcgtgtggag    960

aagcgcctca agaccaaggc agtgcgcatg atcgccatag tgctggccat cttcctggtc   1020

tgcttcgtgc cctaccacgt caaccgctcc gtctacgtgc tgcactaccg cagccatggg   1080

gcctcctgcg ccacccagcg catcctggcc ctggcaaacc gcatcacctc ctgcctcacc   1140

agcctcaacg gggcactcga ccccatcatg tatttcttcg tggctgagaa gttccgccac   1200

gccctgtgca acttgctctg tggcaaaagg ctcaagggcc cgccccccag cttcgaaggg   1260

aaaaccaacg agagctcgct gagtgccaag tcagagctgt gagcgggggg cgccgtccag   1320

gccgagcgca gactgtttag gactcagcag acccagcaag aggcatctgc cctttcccca   1380

gccacctccc cagcaagcaa cctgaaatct cagcagatgc ccaccatttc tctagatcgc   1440

ctagtctcaa cccataaaaa ggaagaactg acaaagggga tccatcggcc acccctctgc   1500

aggggcttgt gatggctaca atggctccta gacactcaac gacttcatct gtggcaggga   1560

gagaggaggc cggaagaaca acccctgaac aatggaggcc tttctttccc gctaggctcc   1620

cagcctcctt cccgctacag aatcgctcat cggcgaggct cagcagaaag accctgaagg   1680

caggctgcaa atgacccaga agagggacct gggagtcctg gtggggacgg ggagggagtc   1740

tcaatactcc tttgcagtgc aaggtactct gagtcccctc tgtagtgcct ctgccagaca   1800

cacactgcct gagttgaaga gacacaggcc acacatttca ggctggttgc cagcggacgt   1860

cagcactcac ggcctgcagg gactcagcac agctctggat tctggatctc tcctgctgta   1920

accccacgca caagcctgca acccccagag ctctttgaca ggctcccagg cctcccagtc   1980

ctggacaagc atgtgcagtc acgggagctc agctcaggcc agggctgggc tgtgcacctg   2040

cctcccactg acccagaccc acttcctcca gagaggcctc tctccgcctg agctatttcc   2100

cttgctagtg tgcagatatt tccctaacat gtcctttttt gtatttgttt gtacggacca   2160

taaatataac tgtagcttta agactacaca ggttgttatg tttggtcaac atgaagcgtt   2220

tcccagaact tctctgaccc aagaatggtg aagtggtggt acagtggcag aggcagcctc   2280

gtgggctctc ttgctggggc tctggcagct cacagcacat ctgcc                   2325


<210>  8306
<211>  339
<212>  PRT
<213>  Homosapiens

<400>  8306

Met Asn Gly Leu Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser 
1               5                   10                  15      


Leu Ala Thr Ala Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met 
            20                  25                  30          


Leu Phe Ala Ser Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly 
        35                  40                  45              


Asn Thr Leu Ala Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr 
    50                  55                  60                  


Pro Ala Asn Val Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys 
65                  70                  75                  80  


Val Leu Val Leu Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His 
                85                  90                  95      


Trp Pro Phe Gly Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr 
            100                 105                 110         


Leu Asn Met Tyr Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp 
        115                 120                 125             


Arg Phe Leu Ala Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg 
    130                 135                 140                 


Pro Leu Tyr Ala His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala 
145                 150                 155                 160 


Val Ala Met Ala Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn 
                165                 170                 175     


His Thr Val Val Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His 
            180                 185                 190         


Ala Leu Val Ser Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr 
        195                 200                 205             


Val Thr Cys Tyr Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg 
    210                 215                 220                 


Val Glu Lys Arg Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val 
225                 230                 235                 240 


Leu Ala Ile Phe Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser 
                245                 250                 255     


Val Tyr Val Leu His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln 
            260                 265                 270         


Arg Ile Leu Ala Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu 
        275                 280                 285             


Asn Gly Ala Leu Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe 
    290                 295                 300                 


Arg His Ala Leu Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro 
305                 310                 315                 320 


Pro Pro Ser Phe Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys 
                325                 330                 335     


Ser Glu Leu 
            


<210>  8307
<211>  1723
<212>  DNA
<213>  Homosapiens

<400>  8307
gacacaacaa gggacccctc aggaatgaag cagcctttca gggccagagg ggctgtggtc     60

tcccttcctc tccttaaata gccagcgttc cacccacagc ggcaaggagc cccctgccac    120

caccgacacc cacgggcgga gatcacctgc tgccccgcag acccctgtcc cttcctcccg    180

gaccagcagc tagaggctct gactccagcc aaagcatgaa tggccttgaa gtggctcccc    240

caggtctgat caccaacttc tccctggcca cggcagagca atgtggccag gagacgccac    300

tggagaacat gctgttcgcc tccttctact tcccaggcag cccaggatgt gtactgtcac    360

cggccttacc gcaggatcca cagcacggag caaacagcat ttggaagtcg tgttcgcagt    420

acttccggcc ttcaaactgc aaaggggtcg cagagagagg acaagcaaac cacctatcat    480

ccccatgagc agcccaggcc cttgttgggt caggacctga cagcagggga tgaggcactg    540

aggcaggggc atgccgggct gaggctggag cagtgggtcc caggcctggc cagagaggac    600

actggccctt ttgggatggt ggggtgcaaa gggaggtgcc cccgtggaag ctggagaggt    660

ccgtgaggcc acctgtcaaa gggccactgg tgtctactga ggatctggac cctgttggtc    720

cggagaacag gctgggggcg aggcggtttt aagccaggag ggatgagatc cagtctgaag    780

tgtagtgtca cttggtccta tttcgtatac cttctctgtg ggagtatcca gctctctcag    840

aggccatgaa gacccgggta taggagacag aaggaaggga acgcaggaag ggcctgggca    900

cggggaagtg ggaagagctc agggctgcgg ccagcaggag ccagtgtgca caccctccag    960

gcggcagctg ccagcgaggg cccctgtgct ggccacaagc ggggccaaag cctgcctctg   1020

ctttcctcta acaattgtat tttctgtttt ttaattggtt tttccctgtt ctctaaaatg   1080

agtgtcttat tagactaaac tggatatagc cctacccagt gacctgtaga gtcaggaagg   1140

gcttaaactc tttcagcaat gaaaatcttc tgggcacctg ctgtgtgtga gagagagagg   1200

ctttgttctg ggcatatggc cacccctcct agagctttgc ccacccctcc cgctgcctct   1260

acacttagac agcattcctc aggaggctga agacactgtg aggaacagcg gctcttgctc   1320

tgccaggcgg accacaggcc ccacatccat ccaccagcca gtcccatcag ctctaccttg   1380

aaacagagcc agcatctgac ccctggccac caccgccacc acaagcacaa gtgatgttct   1440

ggtaaatgct caacagccag ctctctgggg cgcagaggca ggccctgctg tggggcgttt   1500

gccagtgtcc atggtgtgaa tattcccgtc atggccaact cctggctgcc aacatgacat   1560

cgatgtggac ttgaggggag atgtgcagtg gccacaccag cacaatggac agaaataacc   1620

ccatcagcat agacgatagt aaagtggaac aaaataatta gcaagtggta tgctttgagt   1680

atttgttacc tttgttttta ataaaattgt atcccattgt acg                     1723


<210>  8308
<211>  90
<212>  PRT
<213>  Homosapiens

<400>  8308

Met Asn Gly Leu Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser 
1               5                   10                  15      


Leu Ala Thr Ala Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met 
            20                  25                  30          


Leu Phe Ala Ser Phe Tyr Phe Pro Gly Ser Pro Gly Cys Val Leu Ser 
        35                  40                  45              


Pro Ala Leu Pro Gln Asp Pro Gln His Gly Ala Asn Ser Ile Trp Lys 
    50                  55                  60                  


Ser Cys Ser Gln Tyr Phe Arg Pro Ser Asn Cys Lys Gly Val Ala Glu 
65                  70                  75                  80  


Arg Gly Gln Ala Asn His Leu Ser Ser Pro 
                85                  90  


<210>  8309
<211>  1508
<212>  DNA
<213>  Homosapiens

<400>  8309
ccaccgacac ccacgggcgg agatcacctg ctgccccgca gacccctgtc ccttcctccc     60

ggaccagcag ctagaggctc tgactccagc catggccccg ctgctggtga gcccacagac    120

cgtgcagacc aaccacacgg tggtctgcct gcagctgtac cgggagaagg cctcccacca    180

tgccctggtg tccctggcag tggccttcac cttcccgttc atcaccacgg tcacctgcta    240

cctgctgatc atccgcagcc tgcggcaggg cctgcgtgtg gagaagcgcc tcaagaccaa    300

ggcagtgcgc atgatcgcca tagtgctggc catcttcctg gtctgcttcg tgccctacca    360

cgtcaaccgc tccgtctacg tgctgcacta ccgcagccat ggggcctcct gcgccaccca    420

gcgcatcctg gccctggcaa accgcatcac ctcctgcctc accagcctca acggggcact    480

cgaccccatc atgtatttct tcgtggctga gaagttccgc cacgccctgt gcaacttgct    540

ctgtggcaaa aggctcaagg gcccgccccc cagcttcgaa gggaaaacca acgagagctc    600

gctgagtgcc aagtcagagc tgtgagcggg gggcgccgtc caggccgagc gcagactgtt    660

taggactcag cagacccagc aagaggcatc tgccctttcc ccagccacct ccccagcaag    720

caacctgaaa tctcagcaga tgcccaccat ttctctagat cgcctagtct caacccataa    780

aaaggaagaa ctgacaaagg ggatccatcg gccacccctc tgcaggggct tgtgatggct    840

acaatggctc ctagacactc aacgacttca tctgtggcag ggagagagga ggccggaaga    900

acaacccctg aacaatggag gcctttcttt cccgctaggc tcccagcctc cttcccgcta    960

cagaatcgct catcggcgag gctcagcaga aagaccctga aggcaggctg caaatgaccc   1020

agaagaggga cctgggagtc ctggtgggga cggggaggga gtctcaatac tcctttgcag   1080

tgcaaggtac tctgagtccc ctctgtagtg cctctgccag acacacactg cctgagttga   1140

agagacacag gccacacatt tcaggctggt tgccagcgga cgtcagcact cacggcctgc   1200

agggactcag cacagctctg gattctggat ctctcctgct gtaaccccac gcacaagcct   1260

gcaaccccca gagctctttg acaggctccc aggcctccca gtcctggaca agcatgtgca   1320

gtcacgggag ctcagctcag gccagggctg ggctgtgcac ctgcctccca ctgacccaga   1380

cccacttcct ccagagaggc ctctctccgc ctgagctatt tcccttgcta gtgtgcagat   1440

atttccctaa catgtccttt tttgtatttg tttgtacgga ccataaatat aactgtagct   1500

ttaagact                                                            1508


<210>  8310
<211>  177
<212>  PRT
<213>  Homosapiens

<400>  8310

Met Ala Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn His Thr 
1               5                   10                  15      


Val Val Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His Ala Leu 
            20                  25                  30          


Val Ser Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr Val Thr 
        35                  40                  45              


Cys Tyr Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg Val Glu 
    50                  55                  60                  


Lys Arg Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val Leu Ala 
65                  70                  75                  80  


Ile Phe Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser Val Tyr 
                85                  90                  95      


Val Leu His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln Arg Ile 
            100                 105                 110         


Leu Ala Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu Asn Gly 
        115                 120                 125             


Ala Leu Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe Arg His 
    130                 135                 140                 


Ala Leu Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro Pro Pro 
145                 150                 155                 160 


Ser Phe Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys Ser Glu 
                165                 170                 175     


Leu 
    


<210>  8311
<211>  1648
<212>  DNA
<213>  Homosapiens

<400>  8311
ccaccgacac ccacgggcgg agatcacctg ctgccccgca gacccctgtc ccttcctccc     60

ggaccagcag ctagaggctc tgactccagc catggccccg ctgctggtga gcccacagac    120

cgtgcagacc aaccacacgg tggtctgcct gcagctgtac cgggagaagg cctcccacca    180

tgccctggtg tccctggcag tggccttcac cttcccgttc atcaccacgg tcacctgcta    240

cctgctgatc atccgcagcc tgcggcaggg cctgcgtgtg gagaagcgcc tcaagaccaa    300

ggcagtgcgc atgatcgcca tagtgctggc catcttcctg gtctgcttcg tgccctacca    360

cgtcaaccgc tccgtctacg tgctgcacta ccgcagccat ggggcctcct gcgccaccca    420

gcgcatcctg gccctggcaa accgcatcac ctcctgcctc accagcctca acggggcact    480

cgaccccatc atgtatttct tcgtggctga gaagttccgc cacgccctgt gcaacttgct    540

ctgtggcaaa aggctcaagg gcccgccccc cagcttcgaa gggaaaacca acgagagctc    600

gctgagtgcc aagtcagagc tgtgagcggg gggcgccgtc caggccgagc gcagactgtt    660

taggactcag cagacccagc aagaggcatc tgccctttcc ccagccacct ccccagcaag    720

caacctgaaa tctcagcaga tgcccaccat ttctctagat cgcctagtct caacccataa    780

aaaggaagaa ctgacaaagg ggatccatcg gccacccctc tgcaggggct tgtgatggct    840

acaatggctc ctagacactc aacgacttca tctgtggcag ggagagagga ggccggaaga    900

acaacccctg aacaatggag gcctttcttt cccgctaggc tcccagcctc cttcccgcta    960

cagaatcgct catcggcgag gctcagcaga aagaccctga aggcaggctg caaatgaccc   1020

agaagaggga cctgggagtc ctggtgggga cggggaggga gtctcaatac tcctttgcag   1080

tgcaaggtac tctgagtccc ctctgtagtg cctctgccag acacacactg cctgagttga   1140

agagacacag gccacacatt tcaggctggt tgccagcgga cgtcagcact cacggcctgc   1200

agggactcag cacagctctg gattctggat ctctcctgct gtaaccccac gcacaagcct   1260

gcaaccccca gagctctttg acaggctccc aggcctccca gtcctggaca agcatgtgca   1320

gtcacgggag ctcagctcag gccagggctg ggctgtgcac ctgcctccca ctgacccaga   1380

cccacttcct ccagagaggc ctctctccgc ctgagctatt tcccttgcta gtgtgcagat   1440

atttccctaa catgtccttt tttgtatttg tttgtacgga ccataaatat aactgtagct   1500

ttaagactac acaggttgtt atgtttggtc aacatgaagc gtttcccaga acttctctga   1560

cccaagaatg gtgaagtggt ggtacagtgg cagaggcagc ctcgtgggct ctcttgctgg   1620

ggctctggca gctcacagca catctgcc                                      1648


<210>  8312
<211>  177
<212>  PRT
<213>  Homosapiens

<400>  8312

Met Ala Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn His Thr 
1               5                   10                  15      


Val Val Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His Ala Leu 
            20                  25                  30          


Val Ser Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr Val Thr 
        35                  40                  45              


Cys Tyr Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg Val Glu 
    50                  55                  60                  


Lys Arg Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val Leu Ala 
65                  70                  75                  80  


Ile Phe Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser Val Tyr 
                85                  90                  95      


Val Leu His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln Arg Ile 
            100                 105                 110         


Leu Ala Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu Asn Gly 
        115                 120                 125             


Ala Leu Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe Arg His 
    130                 135                 140                 


Ala Leu Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro Pro Pro 
145                 150                 155                 160 


Ser Phe Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys Ser Glu 
                165                 170                 175     


Leu 
    


<210>  8313
<211>  2061
<212>  DNA
<213>  Homosapiens

<400>  8313
ccgacaccca cgggcggaga tcacctgctg ccccgcagac ccctgtccct tcctcccgga     60

ccagcagcta gaggatgtcc aaacggagtt ggtgggctgg atccagaaag cccccaagag    120

agatgctgaa actctcaggc tctgactcca gccaaagcat gaatggcctt gaagtggctc    180

ccccaggtct gatcaccaac ttctccctgg ccacggcaga gcaatgtggc caggagacgc    240

cactggagaa catgctgttc gcctccttct accttctgga ttttatcctg gctttagttg    300

gcaataccct ggctctgtgg cttttcatcc gagaccacaa gtccgggacc ccggccaacg    360

tgttcctgat gcatctggcc gtggccgact tgtcgtgcgt gctggtcctg cccacccgcc    420

tggtctacca cttctctggg aaccactggc catttgggga aatcgcatgc cgtctcaccg    480

gcttcctctt ctacctcaac atgtacgcca gcatctactt cctcacctgc atcagcgccg    540

accgtttcct ggccattgtg cacccggtca agtccctcaa gctccgcagg cccctctacg    600

cacacctggc ctgtgccttc ctgtgggtgg tggtggctgt ggccatggcc ccgctgctgg    660

tgagcccaca gaccgtgcag accaaccaca cggtggtctg cctgcagctg taccgggaga    720

aggcctccca ccatgccctg gtgtccctgg cagtggcctt caccttcccg ttcatcacca    780

cggtcacctg ctacctgctg atcatccgca gcctgcggca gggcctgcgt gtggagaagc    840

gcctcaagac caaggcagtg cgcatgatcg ccatagtgct ggccatcttc ctggtctgct    900

tcgtgcccta ccacgtcaac cgctccgtct acgtgctgca ctaccgcagc catggggcct    960

cctgcgccac ccagcgcatc ctggccctgg caaaccgcat cacctcctgc ctcaccagcc   1020

tcaacggggc actcgacccc atcatgtatt tcttcgtggc tgagaagttc cgccacgccc   1080

tgtgcaactt gctctgtggc aaaaggctca agggcccgcc ccccagcttc gaagggaaaa   1140

ccaacgagag ctcgctgagt gccaagtcag agctgtgagc ggggggcgcc gtccaggccg   1200

agcgcagact gtttaggact cagcagaccc agcaagaggc atctgccctt tccccagcca   1260

cctccccagc aagcaacctg aaatctcagc agatgcccac catttctcta gatcgcctag   1320

tctcaaccca taaaaaggaa gaactgacaa aggggatcca tcggccaccc ctctgcaggg   1380

gcttgtgatg gctacaatgg ctcctagaca ctcaacgact tcatctgtgg cagggagaga   1440

ggaggccgga agaacaaccc ctgaacaatg gaggcctttc tttcccgcta ggctcccagc   1500

ctccttcccg ctacagaatc gctcatcggc gaggctcagc agaaagaccc tgaaggcagg   1560

ctgcaaatga cccagaagag ggacctggga gtcctggtgg ggacggggag ggagtctcaa   1620

tactcctttg cagtgcaagg tactctgagt cccctctgta gtgcctctgc cagacacaca   1680

ctgcctgagt tgaagagaca caggccacac atttcaggct ggttgccagc ggacgtcagc   1740

actcacggcc tgcagggact cagcacagct ctggattctg gatctctcct gctgtaaccc   1800

cacgcacaag cctgcaaccc ccagagctct ttgacaggct cccaggcctc ccagtcctgg   1860

acaagcatgt gcagtcacgg gagctcagct caggccaggg ctgggctgtg cacctgcctc   1920

ccactgaccc agacccactt cctccagaga ggcctctctc cgcctgagct atttcccttg   1980

ctagtgtgca gatatttccc taacatgtcc ttttttgtat ttgtttgtac ggaccataaa   2040

tataactgta gctttaagac t                                             2061


<210>  8314
<211>  367
<212>  PRT
<213>  Homosapiens

<400>  8314

Met Ser Lys Arg Ser Trp Trp Ala Gly Ser Arg Lys Pro Pro Arg Glu 
1               5                   10                  15      


Met Leu Lys Leu Ser Gly Ser Asp Ser Ser Gln Ser Met Asn Gly Leu 
            20                  25                  30          


Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser Leu Ala Thr Ala 
        35                  40                  45              


Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met Leu Phe Ala Ser 
    50                  55                  60                  


Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly Asn Thr Leu Ala 
65                  70                  75                  80  


Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr Pro Ala Asn Val 
                85                  90                  95      


Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys Val Leu Val Leu 
            100                 105                 110         


Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His Trp Pro Phe Gly 
        115                 120                 125             


Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr Leu Asn Met Tyr 
    130                 135                 140                 


Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp Arg Phe Leu Ala 
145                 150                 155                 160 


Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg Pro Leu Tyr Ala 
                165                 170                 175     


His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala Val Ala Met Ala 
            180                 185                 190         


Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn His Thr Val Val 
        195                 200                 205             


Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His Ala Leu Val Ser 
    210                 215                 220                 


Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr Val Thr Cys Tyr 
225                 230                 235                 240 


Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg Val Glu Lys Arg 
                245                 250                 255     


Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val Leu Ala Ile Phe 
            260                 265                 270         


Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser Val Tyr Val Leu 
        275                 280                 285             


His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln Arg Ile Leu Ala 
    290                 295                 300                 


Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu Asn Gly Ala Leu 
305                 310                 315                 320 


Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe Arg His Ala Leu 
                325                 330                 335     


Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro Pro Pro Ser Phe 
            340                 345                 350         


Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys Ser Glu Leu 
        355                 360                 365         


<210>  8315
<211>  2193
<212>  DNA
<213>  Homosapiens

<400>  8315
ccgcagaccc ctgtcccttc ctcccggacc agcagctaga gctctccgcc ctcaccgtgg     60

ttttagcagt cctagggaaa gtgccagccg agaccagcca gaccaagtca gagtactgtg    120

gaacctggat tcctggggaa tggggtcccc atgaggaact ccacattgga ctaagaacag    180

accctgttcc tggaagcagc aggaaaccat ctctggtgtt agaacttcag gcatcttgaa    240

acactctgaa gccgggggca atcttttcag gctctgactc cagccaaagc atgaatggcc    300

ttgaagtggc tcccccaggt ctgatcacca acttctccct ggccacggca gagcaatgtg    360

gccaggagac gccactggag aacatgctgt tcgcctcctt ctaccttctg gattttatcc    420

tggctttagt tggcaatacc ctggctctgt ggcttttcat ccgagaccac aagtccggga    480

ccccggccaa cgtgttcctg atgcatctgg ccgtggccga cttgtcgtgc gtgctggtcc    540

tgcccacccg cctggtctac cacttctctg ggaaccactg gccatttggg gaaatcgcat    600

gccgtctcac cggcttcctc ttctacctca acatgtacgc cagcatctac ttcctcacct    660

gcatcagcgc cgaccgtttc ctggccattg tgcacccggt caagtccctc aagctccgca    720

ggcccctcta cgcacacctg gcctgtgcct tcctgtgggt ggtggtggct gtggccatgg    780

ccccgctgct ggtgagccca cagaccgtgc agaccaacca cacggtggtc tgcctgcagc    840

tgtaccggga gaaggcctcc caccatgccc tggtgtccct ggcagtggcc ttcaccttcc    900

cgttcatcac cacggtcacc tgctacctgc tgatcatccg cagcctgcgg cagggcctgc    960

gtgtggagaa gcgcctcaag accaaggcag tgcgcatgat cgccatagtg ctggccatct   1020

tcctggtctg cttcgtgccc taccacgtca accgctccgt ctacgtgctg cactaccgca   1080

gccatggggc ctcctgcgcc acccagcgca tcctggccct ggcaaaccgc atcacctcct   1140

gcctcaccag cctcaacggg gcactcgacc ccatcatgta tttcttcgtg gctgagaagt   1200

tccgccacgc cctgtgcaac ttgctctgtg gcaaaaggct caagggcccg ccccccagct   1260

tcgaagggaa aaccaacgag agctcgctga gtgccaagtc agagctgtga gcggggggcg   1320

ccgtccaggc cgagcgcaga ctgtttagga ctcagcagac ccagcaagag gcatctgccc   1380

tttccccagc cacctcccca gcaagcaacc tgaaatctca gcagatgccc accatttctc   1440

tagatcgcct agtctcaacc cataaaaagg aagaactgac aaaggggatc catcggccac   1500

ccctctgcag gggcttgtga tggctacaat ggctcctaga cactcaacga cttcatctgt   1560

ggcagggaga gaggaggccg gaagaacaac ccctgaacaa tggaggcctt tctttcccgc   1620

taggctccca gcctccttcc cgctacagaa tcgctcatcg gcgaggctca gcagaaagac   1680

cctgaaggca ggctgcaaat gacccagaag agggacctgg gagtcctggt ggggacgggg   1740

agggagtctc aatactcctt tgcagtgcaa ggtactctga gtcccctctg tagtgcctct   1800

gccagacaca cactgcctga gttgaagaga cacaggccac acatttcagg ctggttgcca   1860

gcggacgtca gcactcacgg cctgcaggga ctcagcacag ctctggattc tggatctctc   1920

ctgctgtaac cccacgcaca agcctgcaac ccccagagct ctttgacagg ctcccaggcc   1980

tcccagtcct ggacaagcat gtgcagtcac gggagctcag ctcaggccag ggctgggctg   2040

tgcacctgcc tcccactgac ccagacccac ttcctccaga gaggcctctc tccgcctgag   2100

ctatttccct tgctagtgtg cagatatttc cctaacatgt ccttttttgt atttgtttgt   2160

acggaccata aatataactg tagctttaag act                                2193


<210>  8316
<211>  339
<212>  PRT
<213>  Homosapiens

<400>  8316

Met Asn Gly Leu Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser 
1               5                   10                  15      


Leu Ala Thr Ala Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met 
            20                  25                  30          


Leu Phe Ala Ser Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly 
        35                  40                  45              


Asn Thr Leu Ala Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr 
    50                  55                  60                  


Pro Ala Asn Val Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys 
65                  70                  75                  80  


Val Leu Val Leu Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His 
                85                  90                  95      


Trp Pro Phe Gly Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr 
            100                 105                 110         


Leu Asn Met Tyr Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp 
        115                 120                 125             


Arg Phe Leu Ala Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg 
    130                 135                 140                 


Pro Leu Tyr Ala His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala 
145                 150                 155                 160 


Val Ala Met Ala Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn 
                165                 170                 175     


His Thr Val Val Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His 
            180                 185                 190         


Ala Leu Val Ser Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr 
        195                 200                 205             


Val Thr Cys Tyr Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg 
    210                 215                 220                 


Val Glu Lys Arg Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val 
225                 230                 235                 240 


Leu Ala Ile Phe Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser 
                245                 250                 255     


Val Tyr Val Leu His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln 
            260                 265                 270         


Arg Ile Leu Ala Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu 
        275                 280                 285             


Asn Gly Ala Leu Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe 
    290                 295                 300                 


Arg His Ala Leu Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro 
305                 310                 315                 320 


Pro Pro Ser Phe Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys 
                325                 330                 335     


Ser Glu Leu 
            


<210>  8317
<211>  2333
<212>  DNA
<213>  Homosapiens

<400>  8317
ccgcagaccc ctgtcccttc ctcccggacc agcagctaga gctctccgcc ctcaccgtgg     60

ttttagcagt cctagggaaa gtgccagccg agaccagcca gaccaagtca gagtactgtg    120

gaacctggat tcctggggaa tggggtcccc atgaggaact ccacattgga ctaagaacag    180

accctgttcc tggaagcagc aggaaaccat ctctggtgtt agaacttcag gcatcttgaa    240

acactctgaa gccgggggca atcttttcag gctctgactc cagccaaagc atgaatggcc    300

ttgaagtggc tcccccaggt ctgatcacca acttctccct ggccacggca gagcaatgtg    360

gccaggagac gccactggag aacatgctgt tcgcctcctt ctaccttctg gattttatcc    420

tggctttagt tggcaatacc ctggctctgt ggcttttcat ccgagaccac aagtccggga    480

ccccggccaa cgtgttcctg atgcatctgg ccgtggccga cttgtcgtgc gtgctggtcc    540

tgcccacccg cctggtctac cacttctctg ggaaccactg gccatttggg gaaatcgcat    600

gccgtctcac cggcttcctc ttctacctca acatgtacgc cagcatctac ttcctcacct    660

gcatcagcgc cgaccgtttc ctggccattg tgcacccggt caagtccctc aagctccgca    720

ggcccctcta cgcacacctg gcctgtgcct tcctgtgggt ggtggtggct gtggccatgg    780

ccccgctgct ggtgagccca cagaccgtgc agaccaacca cacggtggtc tgcctgcagc    840

tgtaccggga gaaggcctcc caccatgccc tggtgtccct ggcagtggcc ttcaccttcc    900

cgttcatcac cacggtcacc tgctacctgc tgatcatccg cagcctgcgg cagggcctgc    960

gtgtggagaa gcgcctcaag accaaggcag tgcgcatgat cgccatagtg ctggccatct   1020

tcctggtctg cttcgtgccc taccacgtca accgctccgt ctacgtgctg cactaccgca   1080

gccatggggc ctcctgcgcc acccagcgca tcctggccct ggcaaaccgc atcacctcct   1140

gcctcaccag cctcaacggg gcactcgacc ccatcatgta tttcttcgtg gctgagaagt   1200

tccgccacgc cctgtgcaac ttgctctgtg gcaaaaggct caagggcccg ccccccagct   1260

tcgaagggaa aaccaacgag agctcgctga gtgccaagtc agagctgtga gcggggggcg   1320

ccgtccaggc cgagcgcaga ctgtttagga ctcagcagac ccagcaagag gcatctgccc   1380

tttccccagc cacctcccca gcaagcaacc tgaaatctca gcagatgccc accatttctc   1440

tagatcgcct agtctcaacc cataaaaagg aagaactgac aaaggggatc catcggccac   1500

ccctctgcag gggcttgtga tggctacaat ggctcctaga cactcaacga cttcatctgt   1560

ggcagggaga gaggaggccg gaagaacaac ccctgaacaa tggaggcctt tctttcccgc   1620

taggctccca gcctccttcc cgctacagaa tcgctcatcg gcgaggctca gcagaaagac   1680

cctgaaggca ggctgcaaat gacccagaag agggacctgg gagtcctggt ggggacgggg   1740

agggagtctc aatactcctt tgcagtgcaa ggtactctga gtcccctctg tagtgcctct   1800

gccagacaca cactgcctga gttgaagaga cacaggccac acatttcagg ctggttgcca   1860

gcggacgtca gcactcacgg cctgcaggga ctcagcacag ctctggattc tggatctctc   1920

ctgctgtaac cccacgcaca agcctgcaac ccccagagct ctttgacagg ctcccaggcc   1980

tcccagtcct ggacaagcat gtgcagtcac gggagctcag ctcaggccag ggctgggctg   2040

tgcacctgcc tcccactgac ccagacccac ttcctccaga gaggcctctc tccgcctgag   2100

ctatttccct tgctagtgtg cagatatttc cctaacatgt ccttttttgt atttgtttgt   2160

acggaccata aatataactg tagctttaag actacacagg ttgttatgtt tggtcaacat   2220

gaagcgtttc ccagaacttc tctgacccaa gaatggtgaa gtggtggtac agtggcagag   2280

gcagcctcgt gggctctctt gctggggctc tggcagctca cagcacatct gcc          2333


<210>  8318
<211>  339
<212>  PRT
<213>  Homosapiens

<400>  8318

Met Asn Gly Leu Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser 
1               5                   10                  15      


Leu Ala Thr Ala Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met 
            20                  25                  30          


Leu Phe Ala Ser Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly 
        35                  40                  45              


Asn Thr Leu Ala Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr 
    50                  55                  60                  


Pro Ala Asn Val Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys 
65                  70                  75                  80  


Val Leu Val Leu Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His 
                85                  90                  95      


Trp Pro Phe Gly Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr 
            100                 105                 110         


Leu Asn Met Tyr Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp 
        115                 120                 125             


Arg Phe Leu Ala Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg 
    130                 135                 140                 


Pro Leu Tyr Ala His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala 
145                 150                 155                 160 


Val Ala Met Ala Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn 
                165                 170                 175     


His Thr Val Val Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His 
            180                 185                 190         


Ala Leu Val Ser Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr 
        195                 200                 205             


Val Thr Cys Tyr Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg 
    210                 215                 220                 


Val Glu Lys Arg Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val 
225                 230                 235                 240 


Leu Ala Ile Phe Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser 
                245                 250                 255     


Val Tyr Val Leu His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln 
            260                 265                 270         


Arg Ile Leu Ala Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu 
        275                 280                 285             


Asn Gly Ala Leu Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe 
    290                 295                 300                 


Arg His Ala Leu Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro 
305                 310                 315                 320 


Pro Pro Ser Phe Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys 
                325                 330                 335     


Ser Glu Leu 
            


<210>  8319
<211>  2154
<212>  DNA
<213>  Homosapiens

<400>  8319
agctctccgc cctcaccgtg gttttagcag tcctagggaa agtgccagcc gagaccagcc     60

agaccaagtc agagtactgt ggaacctgga ttcctgggga atggggtccc catgaggaac    120

tccacattgg actaagaaca gaccctgttc ctggaagcag caggaaacca tctctggtgt    180

tagaacttca ggcatcttga aacactctga agccgggggc aatcttttca ggctctgact    240

ccagccaaag catgaatggc cttgaagtgg ctcccccagg tctgatcacc aacttctccc    300

tggccacggc agagcaatgt ggccaggaga cgccactgga gaacatgctg ttcgcctcct    360

tctaccttct ggattttatc ctggctttag ttggcaatac cctggctctg tggcttttca    420

tccgagacca caagtccggg accccggcca acgtgttcct gatgcatctg gccgtggccg    480

acttgtcgtg cgtgctggtc ctgcccaccc gcctggtcta ccacttctct gggaaccact    540

ggccatttgg ggaaatcgca tgccgtctca ccggcttcct cttctacctc aacatgtacg    600

ccagcatcta cttcctcacc tgcatcagcg ccgaccgttt cctggccatt gtgcacccgg    660

tcaagtccct caagctccgc aggcccctct acgcacacct ggcctgtgcc ttcctgtggg    720

tggtggtggc tgtggccatg gccccgctgc tggtgagccc acagaccgtg cagaccaacc    780

acacggtggt ctgcctgcag ctgtaccggg agaaggcctc ccaccatgcc ctggtgtccc    840

tggcagtggc cttcaccttc ccgttcatca ccacggtcac ctgctacctg ctgatcatcc    900

gcagcctgcg gcagggcctg cgtgtggaga agcgcctcaa gaccaaggca gtgcgcatga    960

tcgccatagt gctggccatc ttcctggtct gcttcgtgcc ctaccacgtc aaccgctccg   1020

tctacgtgct gcactaccgc agccatgggg cctcctgcgc cacccagcgc atcctggccc   1080

tggcaaaccg catcacctcc tgcctcacca gcctcaacgg ggcactcgac cccatcatgt   1140

atttcttcgt ggctgagaag ttccgccacg ccctgtgcaa cttgctctgt ggcaaaaggc   1200

tcaagggccc gccccccagc ttcgaaggga aaaccaacga gagctcgctg agtgccaagt   1260

cagagctgtg agcggggggc gccgtccagg ccgagcgcag actgtttagg actcagcaga   1320

cccagcaaga ggcatctgcc ctttccccag ccacctcccc agcaagcaac ctgaaatctc   1380

agcagatgcc caccatttct ctagatcgcc tagtctcaac ccataaaaag gaagaactga   1440

caaaggggat ccatcggcca cccctctgca ggggcttgtg atggctacaa tggctcctag   1500

acactcaacg acttcatctg tggcagggag agaggaggcc ggaagaacaa cccctgaaca   1560

atggaggcct ttctttcccg ctaggctccc agcctccttc ccgctacaga atcgctcatc   1620

ggcgaggctc agcagaaaga ccctgaaggc aggctgcaaa tgacccagaa gagggacctg   1680

ggagtcctgg tggggacggg gagggagtct caatactcct ttgcagtgca aggtactctg   1740

agtcccctct gtagtgcctc tgccagacac acactgcctg agttgaagag acacaggcca   1800

cacatttcag gctggttgcc agcggacgtc agcactcacg gcctgcaggg actcagcaca   1860

gctctggatt ctggatctct cctgctgtaa ccccacgcac aagcctgcaa cccccagagc   1920

tctttgacag gctcccaggc ctcccagtcc tggacaagca tgtgcagtca cgggagctca   1980

gctcaggcca gggctgggct gtgcacctgc ctcccactga cccagaccca cttcctccag   2040

agaggcctct ctccgcctga gctatttccc ttgctagtgt gcagatattt ccctaacatg   2100

tccttttttg tatttgtttg tacggaccat aaatataact gtagctttaa gact         2154


<210>  8320
<211>  339
<212>  PRT
<213>  Homosapiens

<400>  8320

Met Asn Gly Leu Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser 
1               5                   10                  15      


Leu Ala Thr Ala Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met 
            20                  25                  30          


Leu Phe Ala Ser Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly 
        35                  40                  45              


Asn Thr Leu Ala Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr 
    50                  55                  60                  


Pro Ala Asn Val Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys 
65                  70                  75                  80  


Val Leu Val Leu Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His 
                85                  90                  95      


Trp Pro Phe Gly Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr 
            100                 105                 110         


Leu Asn Met Tyr Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp 
        115                 120                 125             


Arg Phe Leu Ala Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg 
    130                 135                 140                 


Pro Leu Tyr Ala His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala 
145                 150                 155                 160 


Val Ala Met Ala Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn 
                165                 170                 175     


His Thr Val Val Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His 
            180                 185                 190         


Ala Leu Val Ser Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr 
        195                 200                 205             


Val Thr Cys Tyr Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg 
    210                 215                 220                 


Val Glu Lys Arg Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val 
225                 230                 235                 240 


Leu Ala Ile Phe Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser 
                245                 250                 255     


Val Tyr Val Leu His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln 
            260                 265                 270         


Arg Ile Leu Ala Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu 
        275                 280                 285             


Asn Gly Ala Leu Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe 
    290                 295                 300                 


Arg His Ala Leu Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro 
305                 310                 315                 320 


Pro Pro Ser Phe Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys 
                325                 330                 335     


Ser Glu Leu 
            


<210>  8321
<211>  2294
<212>  DNA
<213>  Homosapiens

<400>  8321
agctctccgc cctcaccgtg gttttagcag tcctagggaa agtgccagcc gagaccagcc     60

agaccaagtc agagtactgt ggaacctgga ttcctgggga atggggtccc catgaggaac    120

tccacattgg actaagaaca gaccctgttc ctggaagcag caggaaacca tctctggtgt    180

tagaacttca ggcatcttga aacactctga agccgggggc aatcttttca ggctctgact    240

ccagccaaag catgaatggc cttgaagtgg ctcccccagg tctgatcacc aacttctccc    300

tggccacggc agagcaatgt ggccaggaga cgccactgga gaacatgctg ttcgcctcct    360

tctaccttct ggattttatc ctggctttag ttggcaatac cctggctctg tggcttttca    420

tccgagacca caagtccggg accccggcca acgtgttcct gatgcatctg gccgtggccg    480

acttgtcgtg cgtgctggtc ctgcccaccc gcctggtcta ccacttctct gggaaccact    540

ggccatttgg ggaaatcgca tgccgtctca ccggcttcct cttctacctc aacatgtacg    600

ccagcatcta cttcctcacc tgcatcagcg ccgaccgttt cctggccatt gtgcacccgg    660

tcaagtccct caagctccgc aggcccctct acgcacacct ggcctgtgcc ttcctgtggg    720

tggtggtggc tgtggccatg gccccgctgc tggtgagccc acagaccgtg cagaccaacc    780

acacggtggt ctgcctgcag ctgtaccggg agaaggcctc ccaccatgcc ctggtgtccc    840

tggcagtggc cttcaccttc ccgttcatca ccacggtcac ctgctacctg ctgatcatcc    900

gcagcctgcg gcagggcctg cgtgtggaga agcgcctcaa gaccaaggca gtgcgcatga    960

tcgccatagt gctggccatc ttcctggtct gcttcgtgcc ctaccacgtc aaccgctccg   1020

tctacgtgct gcactaccgc agccatgggg cctcctgcgc cacccagcgc atcctggccc   1080

tggcaaaccg catcacctcc tgcctcacca gcctcaacgg ggcactcgac cccatcatgt   1140

atttcttcgt ggctgagaag ttccgccacg ccctgtgcaa cttgctctgt ggcaaaaggc   1200

tcaagggccc gccccccagc ttcgaaggga aaaccaacga gagctcgctg agtgccaagt   1260

cagagctgtg agcggggggc gccgtccagg ccgagcgcag actgtttagg actcagcaga   1320

cccagcaaga ggcatctgcc ctttccccag ccacctcccc agcaagcaac ctgaaatctc   1380

agcagatgcc caccatttct ctagatcgcc tagtctcaac ccataaaaag gaagaactga   1440

caaaggggat ccatcggcca cccctctgca ggggcttgtg atggctacaa tggctcctag   1500

acactcaacg acttcatctg tggcagggag agaggaggcc ggaagaacaa cccctgaaca   1560

atggaggcct ttctttcccg ctaggctccc agcctccttc ccgctacaga atcgctcatc   1620

ggcgaggctc agcagaaaga ccctgaaggc aggctgcaaa tgacccagaa gagggacctg   1680

ggagtcctgg tggggacggg gagggagtct caatactcct ttgcagtgca aggtactctg   1740

agtcccctct gtagtgcctc tgccagacac acactgcctg agttgaagag acacaggcca   1800

cacatttcag gctggttgcc agcggacgtc agcactcacg gcctgcaggg actcagcaca   1860

gctctggatt ctggatctct cctgctgtaa ccccacgcac aagcctgcaa cccccagagc   1920

tctttgacag gctcccaggc ctcccagtcc tggacaagca tgtgcagtca cgggagctca   1980

gctcaggcca gggctgggct gtgcacctgc ctcccactga cccagaccca cttcctccag   2040

agaggcctct ctccgcctga gctatttccc ttgctagtgt gcagatattt ccctaacatg   2100

tccttttttg tatttgtttg tacggaccat aaatataact gtagctttaa gactacacag   2160

gttgttatgt ttggtcaaca tgaagcgttt cccagaactt ctctgaccca agaatggtga   2220

agtggtggta cagtggcaga ggcagcctcg tgggctctct tgctggggct ctggcagctc   2280

acagcacatc tgcc                                                     2294


<210>  8322
<211>  339
<212>  PRT
<213>  Homosapiens

<400>  8322

Met Asn Gly Leu Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser 
1               5                   10                  15      


Leu Ala Thr Ala Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met 
            20                  25                  30          


Leu Phe Ala Ser Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly 
        35                  40                  45              


Asn Thr Leu Ala Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr 
    50                  55                  60                  


Pro Ala Asn Val Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys 
65                  70                  75                  80  


Val Leu Val Leu Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His 
                85                  90                  95      


Trp Pro Phe Gly Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr 
            100                 105                 110         


Leu Asn Met Tyr Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp 
        115                 120                 125             


Arg Phe Leu Ala Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg 
    130                 135                 140                 


Pro Leu Tyr Ala His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala 
145                 150                 155                 160 


Val Ala Met Ala Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn 
                165                 170                 175     


His Thr Val Val Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His 
            180                 185                 190         


Ala Leu Val Ser Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr 
        195                 200                 205             


Val Thr Cys Tyr Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg 
    210                 215                 220                 


Val Glu Lys Arg Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val 
225                 230                 235                 240 


Leu Ala Ile Phe Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser 
                245                 250                 255     


Val Tyr Val Leu His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln 
            260                 265                 270         


Arg Ile Leu Ala Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu 
        275                 280                 285             


Asn Gly Ala Leu Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe 
    290                 295                 300                 


Arg His Ala Leu Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro 
305                 310                 315                 320 


Pro Pro Ser Phe Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys 
                325                 330                 335     


Ser Glu Leu 
            


<210>  8323
<211>  2127
<212>  DNA
<213>  Homosapiens

<400>  8323
atgtccaaac ggagttggtg ggctggatcc agaaagcccc caagagagat gctgaaactc     60

tcaggctctg actccagcca aagcatgaat ggccttgaag tggctccccc aggtctgatc    120

accaacttct ccctggccac ggcagagcaa tgtggccagg agacgccact ggagaacatg    180

ctgttcgcct ccttctacct tctggatttt atcctggctt tagttggcaa taccctggct    240

ctgtggcttt tcatccgaga ccacaagtcc gggaccccgg ccaacgtgtt cctgatgcat    300

ctggccgtgg ccgacttgtc gtgcgtgctg gtcctgccca cccgcctggt ctaccacttc    360

tctgggaacc actggccatt tggggaaatc gcatgccgtc tcaccggctt cctcttctac    420

ctcaacatgt acgccagcat ctacttcctc acctgcatca gcgccgaccg tttcctggcc    480

attgtgcacc cggtcaagtc cctcaagctc cgcaggcccc tctacgcaca cctggcctgt    540

gccttcctgt gggtggtggt ggctgtggcc atggccccgc tgctggtgag cccacagacc    600

gtgcagacca accacacggt ggtctgcctg cagctgtacc gggagaaggc ctcccaccat    660

gccctggtgt ccctggcagt ggccttcacc ttcccgttca tcaccacggt cacctgctac    720

ctgctgatca tccgcagcct gcggcagggc ctgcgtgtgg agaagcgcct caagaccaag    780

gcagtgcgca tgatcgccat agtgctggcc atcttcctgg tctgcttcgt gccctaccac    840

gtcaaccgct ccgtctacgt gctgcactac cgcagccatg gggcctcctg cgccacccag    900

cgcatcctgg ccctggcaaa ccgcatcacc tcctgcctca ccagcctcaa cggggcactc    960

gaccccatca tgtatttctt cgtggctgag aagttccgcc acgccctgtg caacttgctc   1020

tgtggcaaaa ggctcaaggg cccgcccccc agcttcgaag ggaaaaccaa cgagagctcg   1080

ctgagtgcca agtcagagct gtgagcgggg ggcgccgtcc aggccgagcg cagactgttt   1140

aggactcagc agacccagca agaggcatct gccctttccc cagccacctc cccagcaagc   1200

aacctgaaat ctcagcagat gcccaccatt tctctagatc gcctagtctc aacccataaa   1260

aaggaagaac tgacaaaggg gatccatcgg ccacccctct gcaggggctt gtgatggcta   1320

caatggctcc tagacactca acgacttcat ctgtggcagg gagagaggag gccggaagaa   1380

caacccctga acaatggagg cctttctttc ccgctaggct cccagcctcc ttcccgctac   1440

agaatcgctc atcggcgagg ctcagcagaa agaccctgaa ggcaggctgc aaatgaccca   1500

gaagagggac ctgggagtcc tggtggggac ggggagggag tctcaatact cctttgcagt   1560

gcaaggtact ctgagtcccc tctgtagtgc ctctgccaga cacacactgc ctgagttgaa   1620

gagacacagg ccacacattt caggctggtt gccagcggac gtcagcactc acggcctgca   1680

gggactcagc acagctctgg attctggatc tctcctgctg taaccccacg cacaagcctg   1740

caacccccag agctctttga caggctccca ggcctcccag tcctggacaa gcatgtgcag   1800

tcacgggagc tcagctcagg ccagggctgg gctgtgcacc tgcctcccac tgacccagac   1860

ccacttcctc cagagaggcc tctctccgcc tgagctattt cccttgctag tgtgcagata   1920

tttccctaac atgtcctttt ttgtatttgt ttgtacggac cataaatata actgtagctt   1980

taagactaca caggttgtta tgtttggtca acatgaagcg tttcccagaa cttctctgac   2040

ccaagaatgg tgaagtggtg gtacagtggc agaggcagcc tcgtgggctc tcttgctggg   2100

gctctggcag ctcacagcac atctgcc                                       2127


<210>  8324
<211>  367
<212>  PRT
<213>  Homosapiens

<400>  8324

Met Ser Lys Arg Ser Trp Trp Ala Gly Ser Arg Lys Pro Pro Arg Glu 
1               5                   10                  15      


Met Leu Lys Leu Ser Gly Ser Asp Ser Ser Gln Ser Met Asn Gly Leu 
            20                  25                  30          


Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser Leu Ala Thr Ala 
        35                  40                  45              


Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met Leu Phe Ala Ser 
    50                  55                  60                  


Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly Asn Thr Leu Ala 
65                  70                  75                  80  


Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr Pro Ala Asn Val 
                85                  90                  95      


Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys Val Leu Val Leu 
            100                 105                 110         


Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His Trp Pro Phe Gly 
        115                 120                 125             


Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr Leu Asn Met Tyr 
    130                 135                 140                 


Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp Arg Phe Leu Ala 
145                 150                 155                 160 


Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg Pro Leu Tyr Ala 
                165                 170                 175     


His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala Val Ala Met Ala 
            180                 185                 190         


Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn His Thr Val Val 
        195                 200                 205             


Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His Ala Leu Val Ser 
    210                 215                 220                 


Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr Val Thr Cys Tyr 
225                 230                 235                 240 


Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg Val Glu Lys Arg 
                245                 250                 255     


Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val Leu Ala Ile Phe 
            260                 265                 270         


Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser Val Tyr Val Leu 
        275                 280                 285             


His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln Arg Ile Leu Ala 
    290                 295                 300                 


Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu Asn Gly Ala Leu 
305                 310                 315                 320 


Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe Arg His Ala Leu 
                325                 330                 335     


Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro Pro Pro Ser Phe 
            340                 345                 350         


Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys Ser Glu Leu 
        355                 360                 365         


<210>  8325
<211>  275
<212>  DNA
<213>  Homosapiens

<400>  8325
ctaccacttc tctgggaacc actggccatt tggggaaatc gcatgccgtc tcaccggctt     60

cctcttctac ctcaacatgt acgccagcat ctacttcctc acctgcatca gcgccgaccg    120

tttcctggcc attgtgcacc cggtcaagtc cctcaagctc cgcaggcctc tctccgcctg    180

agctatttcc cttgctagtg tgcagatatt tccctaacat gtcctttttt gtatttgttt    240

gtacggacca taaatataac tgtagcttta agact                               275


<210>  8326
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  8326

Met Pro Ser His Arg Leu Pro Leu Leu Pro Gln His Val Arg Gln His 
1               5                   10                  15      


Leu Leu Pro His Leu His Gln Arg Arg Pro Phe Pro Gly His Cys Ala 
            20                  25                  30          


Pro Gly Gln Val Pro Gln Ala Pro Gln Ala Ser Leu Arg Leu Ser Tyr 
        35                  40                  45              


Phe Pro Cys 
    50      


<210>  8327
<211>  1051
<212>  DNA
<213>  Homosapiens

<400>  8327
cccgttcatc accacggtca cctgctacct gctgatcatc cgcagcctgc ggcagggcct     60

gcgtgtggag aagcgcctca agaccaaggc agtgcgcatg atcgccatag tgctggccat    120

cttcctggtc tgcttcgtgc cctaccacgt caaccgctcc gtctacgtgc tgcactaccg    180

cagccatggg gcctcctgcg ccacccagcg catcctggcc ctggcaaacc gcatcacctc    240

ctgcctcacc agcctcaacg gggcactcga ccccatcatg tatttcttcg tggctgagaa    300

gttccgccac gccctgtgca acttgctctg tggcaaaagg ctcaagggcc cgccccccag    360

cttcgaaggg aaaaccaacg agagctcgct gagtgccaag tcagagctgt gagcgggggg    420

cgccgtccag gccgagcgca gactgtttag gactcagcag acccagcaag aggcatctgc    480

cctttcccca gccacctccc cagcaagcaa cctgaaatct cagcagatgc ccaccatttc    540

tctagatcgc ctagtctcaa cccataaaaa ggaagaactg acaaagggga tccatcggcc    600

acccctctgc aggggcttgt gatggctaca atggctccta gacactcaac gacttcatct    660

gtggcaggga gagaggaggc cggaagaaca acccctgaac aatggaggcc tttctttccc    720

gctaggctcc cagcctcctt cccgctacag aatcgctcat cggcgaggct cagcagaaag    780

accctgaagg caggctgcaa atgacccaga agagggacct gggagtcctg gtggggacgg    840

ggagggagtc tcaatactcc tttgcagtgc aaggtactct gagtcccctc tgtagtgcct    900

ctgccagaca cacatgaccc agacccactt cctccagaga ggcctctctc cgcctgagct    960

atttcccttg ctagtgtgca gatatttccc taacatgtcc ttttttgtat ttgtttgtac   1020

ggaccataaa tataactgta gctttaagac t                                  1051


<210>  8328
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  8328

Met Thr Gln Thr His Phe Leu Gln Arg Gly Leu Ser Pro Pro Glu Leu 
1               5                   10                  15      


Phe Pro Leu Leu Val Cys Arg Tyr Phe Pro Asn Met Ser Phe Phe Val 
            20                  25                  30          


Phe Val Cys Thr Asp His Lys Tyr Asn Cys Ser Phe Lys 
        35                  40                  45  


<210>  8329
<211>  1040
<212>  DNA
<213>  Homosapiens

<400>  8329
ggaagaacaa cccctgaaca atggaggcct ttctttcccg ctaggctccc agcctccttc     60

ccgctacaga atcgctcatc ggcgaggctc agcagaaaga ccctgaaggc aggctgcaaa    120

tgacccagaa gagggacctg ggagtcctgg tggggacggg gagggagtct caatactcct    180

ttgcagtgca aggtactctg agtcccctct gtagtgcctc tgccagacac acactgcctg    240

agttgaagag acacaggcca cacatttcag gctggttgcc agcggacgtc agcactcacg    300

gcctgcaggg actcagcaca gctctggatt ctggatctct cctgctgtaa ccccacgcac    360

aagcctgcaa cccccagagc tctttgacag gctcccaggc ctcccagtcc tggacaagca    420

tgtgcagtca cgggagctca gctcaggcca gggctgggct gtgcacctgc ctcccactga    480

cccagaccca cttcctccag agaggcctct ctccgcctga gctatttccc ttgctagtgt    540

gcagatattt ccctaacatg tccttttttg tatttgtttg tacggaccat aaatataact    600

gtagctttaa gactacacag gttgttatgt ttggtcaaca tgaagcgttt cccagaactt    660

ctctgaccca agaatggtga agtggtggta cagtggcaga ggcagcctcg tgggctctct    720

tgctggggct ctggcagctc acagcacatc tgcccagatt ctgaggttct gcactgtggg    780

gctgggaggg ccaagtaggg gccctcattc ctcactctag ctgccacccc tgttggtccg    840

gagaacaggc tgggggcgag gcggttttaa gccaggaggg atgagatcca gtctgaagtg    900

tagtgtcact tggtcctatt tcgtatacct tctctgtggg agtatccagc tctctcagag    960

gccatgaaga cccgggtata ggagacagaa ggaagggaac gcaggaaggg cctgggcacg   1020

gggaagtggg aagagctcag                                               1040


<210>  8330
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  8330

Met Cys Ser His Gly Ser Ser Ala Gln Ala Arg Ala Gly Leu Cys Thr 
1               5                   10                  15      


Cys Leu Pro Leu Thr Gln Thr His Phe Leu Gln Arg Gly Leu Ser Pro 
            20                  25                  30          


Pro Glu Leu Phe Pro Leu Leu Val Cys Arg Tyr Phe Pro Asn Met Ser 
        35                  40                  45              


Phe Phe Val Phe Val Cys Thr Asp His Lys Tyr Asn Cys Ser Phe Lys 
    50                  55                  60                  


Thr Thr Gln Val Val Met Phe Gly Gln His Glu Ala Phe Pro Arg Thr 
65                  70                  75                  80  


Ser Leu Thr Gln Glu Trp 
                85      


<210>  8331
<211>  1477
<212>  DNA
<213>  Homosapiens

<400>  8331
ttctgtctgc aagggcagcc atgagggccg ggcacggagc cccagacgac tccccatgga     60

gagacaggga gaaaggtgac tcagaggagg ggagtgagca ggtgcagctg tgggggcggg    120

cagaaccaca ggaactcagg gtcccgggtg ccagaagggg ggcgtttctg cacctcagca    180

gctgtggtga gggctgctga ggggtcaaga ggaggtgtgg gtccctgggc agatgaggcc    240

agggtagcac acgcgagggg cagcgggtgt gctgggagaa gccggggagg aaggcccagc    300

agtgttttta acccagctcc ccagcccagt ccttcagaaa ggacgagaga tgggtagcac    360

acaggagagg tggcaggtgt gccaggaagg gctgtggccc agtcctctct ggcccaacac    420

ggccacctca cctgccggca ttcttcacaa agcccaggtc agccagctcc acatcacaca    480

gctcgcagcg gaagcagccc gggtgccagt tgttgttcat ggccttgatg acgcggccaa    540

tgatgaactc acctggaaga agacaggtcc ctgctggctg gggagcacgt gcctgtcccc    600

tcttcggacc ctcccaagcc ctgtccacct agcactccgc ctgctctctg cctggcccat    660

gggctccctc gtgggatggt gatgcctgta gggggcctga cggctgccgc tcagagaggc    720

aaggtgggga gttaggaaag agctgggcca gttctgtgta ccccctcggc cccctgcccc    780

ccgccactgc tgcccacttc ccaggcagcc caggatgtgt actgtcaccg gccttaccgc    840

aggatccaca gcacggagca aacagcattt ggaagtcgtg ttcgcagtac ttccggcctt    900

caaactgcaa aggggtcgca gagagaggac aagcaaacca cctatcatcc ccatgagcag    960

cccaggccct tgttgggtca ggacctgaca gcaggggatg aggcactgag gcaggggcat   1020

gccgggctga ggctggagca gtgggtccca ggcctggcca gagaggacac tggccctttt   1080

gggatggtgg ggtgcaaagg gaggtgcccc cgtggaagct ggagaggtcc gtgaggccac   1140

ctgtcaaagg gccactggtg tctactgagg atctggaccc tgttggtccg gagaacaggc   1200

tgggggcgag gcggttttaa gccaggaggg atgagatcca gtctgaagtg tagtgtcact   1260

tggtcctatt tcgtatacct tctctgtggg agtatccagc tctctcagag gccatgaaga   1320

cccgggtata ggagacagaa ggaagggaac gcaggaaggg cctgggcacg gggaagtggg   1380

aagagctcag ggctgcggcc agcaggagcc agtgtgcaca ccctccaggc ggcagctgcc   1440

agcgagggcc cctgtgctgg ccacaagcgg ggccaaa                            1477


<210>  8332
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  8332

Met Gly Ser Thr Gln Glu Arg Trp Gln Val Cys Gln Glu Gly Leu Trp 
1               5                   10                  15      


Pro Ser Pro Leu Trp Pro Asn Thr Ala Thr Ser Pro Ala Gly Ile Leu 
            20                  25                  30          


His Lys Ala Gln Val Ser Gln Leu His Ile Thr Gln Leu Ala Ala Glu 
        35                  40                  45              


Ala Ala Arg Val Pro Val Val Val His Gly Leu Asp Asp Ala Ala Asn 
    50                  55                  60                  


Asp Glu Leu Thr Trp Lys Lys Thr Gly Pro Cys Trp Leu Gly Ser Thr 
65                  70                  75                  80  


Cys Leu Ser Pro Leu Arg Thr Leu Pro Ser Pro Val His Leu Ala Leu 
                85                  90                  95      


Arg Leu Leu Ser Ala Trp Pro Met Gly Ser Leu Val Gly Trp 
            100                 105                 110 


<210>  8333
<211>  664
<212>  DNA
<213>  Homosapiens

<400>  8333
tctgtgatcg ccattaaggc tgtggcctgg ggtctcaggg cagcccagga accaaaaata     60

gcctgtaact tgtcactttg taagtcctgc cctccagaca cacttccctt tcttctcccc    120

aagcctctct tcccagttag ctcccctgac ttggagtcac ctctaagcct tggcccaggc    180

ccctctgcag tgagatggag ggactcatcc cccggagagt ggcatctgca ggcccactgg    240

ctgcctgtgg tcacccccta gggttctagc ggggctgcct cccattttcc tcagagcatc    300

cctgccagct ggctggttct cactctcctg ttttctagga aaagaaagtg gggagagaca    360

ggaacagggt ccggagcagc cccagcagca gcattgaggt ggagagatgg attcttgcca    420

tattgcccag gctggtctcg aactcctggg ctcaagggat ccgcccacct tggcctccca    480

cagtgctctg gatgacaggc ttgagccatt ctgcacacgc acccagctac cctcttgcct    540

gctctgtgtt tgggtggtta tgtgtttatt ggaggcagtc agtttgaaac taactcatgg    600

tgcagaggat ggaaccatgg aagactgagc agtctggatt caagtgtgga ccccgctctg    660

ctgt                                                                 664


<210>  8334
<211>  73
<212>  PRT
<213>  Homosapiens

<400>  8334

Met Asp Ser Cys His Ile Ala Gln Ala Gly Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Arg Asp Pro Pro Thr Leu Ala Ser His Ser Ala Leu Asp Asp Arg Leu 
            20                  25                  30          


Glu Pro Phe Cys Thr Arg Thr Gln Leu Pro Ser Cys Leu Leu Cys Val 
        35                  40                  45              


Trp Val Val Met Cys Leu Leu Glu Ala Val Ser Leu Lys Leu Thr His 
    50                  55                  60                  


Gly Ala Glu Asp Gly Thr Met Glu Asp 
65                  70              


<210>  8335
<211>  2932
<212>  DNA
<213>  Homosapiens

<400>  8335
aaggacctct ggccaagcct cctgcccagg gagaggtgaa gtgccgtctc ttctctgccc     60

cccctttcag agcattctcc ccccaggggc actgtgtgca gcactctggg gagcaccatc    120

tacacagacc ccagggaggg gtgctcctgg gggaggcatt gcaggggccc tgcctgcccc    180

tctgcagctg gactcaggcc cctcactcca agggaccggc tcttgaccca aacccagatg    240

cttccctggc ctctgcacgc agcagtgtgc acacggggca gtggcgcacc tcctccctgg    300

agctctttcc ctccgggctt ctgtggcacc tcacactctc ctgctctccc cctcactttc    360

tgccagtccc acctcttacc cttggagggc tcctgactgg tacagacacc ccagggtctc    420

catggagccc tagagttgaa attccatttg taccaagcct tctgcatcta cgctggagaa    480

tggacctctc ttccctgctc caggttcaca gtgccccgcc caccatctcc cctgggatgc    540

ctggggaggg cccaatgcaa cgtcacccct cgctaacctg cccagactgt cccactgcca    600

ccaatatcta ggaaagcaag gccacctgca agtcctcttg actcccacgg ctgtacattc    660

acacctgcca cacacacacc tgccccacaa ccaccacacc tgtgctgacc acgcccacgc    720

cggccacaca cacacatcca gattcccagc aaatcctgtt ggttgcaaaa tagatcctgt    780

gtttgatgcc ttctcaatgt ccctactgtc gcacggccca aggcaccagt ccctcctgga    840

cgctcaccat agcctctaat cagactgtcc ctgagaccac tctgtccctc acacagtggc    900

cacacagcag ctagggacac ttcccccttt tgctatgaaa aagttcaagc actcatcaaa    960

gttgaaaacc cagataccca ccacctagat tctcccatta atatcgtcgt agactcacgt   1020

taccacctct ctgtccttcc ctttacccat ctccccatct tgagttcatt ttttagaggc   1080

agagtcatgc tatgttgccc aagctggtct tgaattcctg gcctcaagtg atcctccctc   1140

ctcagcctcc ccgtagctaa ggactagctg ggactacggg gatccaccac atcggctcat   1200

cttgatttaa acaatgtatt tcaaagtaag ttgcagacat cagtaccttt ctacctaaac   1260

acttcagcat tgtatgtcat taactggagt tcagtatcgt ttacggtatt tttcttttga   1320

ggtaaaatgt acatataatg aaatgtgcaa atcctggcca tatattccat gagttttaac   1380

aaaggcatat acacttgtgt gacccaaact cctactaaaa cattgcctgt taccccagaa   1440

actccctcac attccttcct agtcaacccc tgtcctgcca cctcagggca gtccggggtg   1500

taatagacca gcctgaggca gccaccgttc tgattttttc taccacagac aaatgttgcc   1560

tattctagaa cttgatatag atggaaaagg tgctcttttt tcattcagtc agtatttctg   1620

agattcaccc ctgctgatgc tagagtgttg tgtctgtctt tgcttagaac tctccatcta   1680

agggtggaat cctacttctg ctgtggccct gctgctctgc cctgggccct ctcctttatt   1740

tcccgtgccc ctccacctgc cacctcccct ttttccagac ccactggtct tctttctgac   1800

cttgcgtacc ccaagctcat gtcacctcag ggctgttgca cttgctgttc tgccggaatg   1860

cttttcctgc agatggctga gggctggctc tttcccttat tctggtttag cttgaatgtc   1920

acctgctcag aaactttccc tcacccttca ctctaaagca gccaccacca ttgtcctttt   1980

ctttgcagca cttacccttg tctaaaatct agtttgcgta tttatttatt tgtttattgc   2040

ccatcctcca cctcctgcta aactccatga gagcctggtc catggcttct ttctccccct   2100

agtacttcca gtgcccatgc ggtataaata ctcttgaagg aacaagtgga taagtgtgtg   2160

aatgtgtgat tgccagctct ttcctgcaac tctgccctct tggctgaact gtgggaggct   2220

ggccctggct ccttgaagcc tctgcatctc cagcagggct aagccatgcc cacaacccct   2280

accagctgtt actgagcttg ccctggccca gggatgaggc acactgggag ctgcataggg   2340

tcctggtttg gccacataca gatccgtgtg tgctcagcta tcatatgcag ggaggctttt   2400

gggctaaaag gcaggaatgt ggtctcctct gtggagagca tgggcctctg gtgtaatgct   2460

ttcaactttt catcctcttt ggttcccaca agaccctgat attcaattaa ccgtccagca   2520

gtggatttct ggtgcacggc cccagcatgc ctacacctct gtgtcagtaa tggtggaaag   2580

cctttctccc tgtatgagca ggtgagccaa gaaattatcc atacttaagc ttaatcaacc   2640

atcaaattac agttaagccg aatcagctga gacacgctcg caacaagaag taataactcg   2700

agacagtcgg atcacctgag gccaggagtt tgcaaccagc ctgaccaaca tggtgaaacc   2760

catctctatc aaaaatacaa aattagctgg gtgtggtggc atatgcttgt aatcccagct   2820

acttgggagg ctgaggcagg agaatcgctt gaacctggga ggcggaggtt gcagtgagcg   2880

gagattgcac cattgcactc cagcctgggc aataagagcg aaactccgtc tc           2932


<210>  8336
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  8336

Met Trp Ser Pro Leu Trp Arg Ala Trp Ala Ser Gly Val Met Leu Ser 
1               5                   10                  15      


Thr Phe His Pro Leu Trp Phe Pro Gln Asp Pro Asp Ile Gln Leu Thr 
            20                  25                  30          


Val Gln Gln Trp Ile Ser Gly Ala Arg Pro Gln His Ala Tyr Thr Ser 
        35                  40                  45              


Val Ser Val Met Val Glu Ser Leu Ser Pro Cys Met Ser Arg 
    50                  55                  60          


<210>  8337
<211>  2928
<212>  DNA
<213>  Homosapiens

<400>  8337
ttgaattttt aagtttttat ttaagaaata aacattgtaa aacatcatta taaaaccccc     60

aactattgca agttctagag aaatttaaaa ctagaacaga aatttagggg actagaaaga    120

gcagccaatg gcacaagtct ttacaattaa ttaaaaaaat aaatcattct gaagatactg    180

catttgctct ctcacaagca gcctcctgag gtaggtaacc ttgtttactg atggggaaca    240

aggcagtgtt ctttaccaaa tctcagggcg ggtagcctgc aagcctacag tgtggatgtt    300

ggccacttgt gtcacttctt gggacggggc ttagggacct gacttactta ggaacataaa    360

ttttggggtt ggaggaagca gcagtgctct actgcggcac gacagacacc ctgttaaggc    420

aacactggga tccagctcag gaaaagcatt actttcaaat tgtgcaagcc aatgcacaga    480

aaagtgtggc tcttcaagta actgatgtgc agtcaagcgc gaggaccact ggcacacaat    540

gtttaaattc taaatatatt ttacttccta gtgtattgct actgacaaaa cgtagttttc    600

tggactcatc agaatgttag gctcatacct tctggcaata aattaaggta gttaaaagta    660

actgctgaac ctaaaatgaa ggcagcagca attagatata aaaaaatctt aagatcagcc    720

tgcaaattgt aaactagttt acaaagcagg ctatacaatg aggaataatt cgagcttgta    780

gaaatccatg gtttccacca gatacaggta ttccggatct agaattatct ttctatttgc    840

aggatttccg aagagaccgt taagcatcta cgcgcccctt cctggatccc atgcttcttg    900

gggcaggaaa tttcttttgg tccgtcgctt tcgtcgtgaa atacacaact aattttcctt    960

tcatgttata aggcaccata tttatgattt tgttaactga agaaaaaacc cgagataaac   1020

catcttaagt acttttaaaa gtccagtggc tgaattcggt gtttaatctg atacccttct   1080

ggattcgctg acactggaga gaataatttc caagtcttag tatagccaaa acaaaaaact   1140

accgtcgcta agctacatct accactggat tttaaaatga caaaacagcc tgagaaaaat   1200

cacaagagca gctaactcga agaaaaatcc tttttcttta ctcagccgaa cctaagacca   1260

cagttacttc gaaagcaact tctaataacc gtctcacatc ctgtcaccag ttcaatgaca   1320

aaatctcagt tttcagagcg tgtgccaagt ccagcacaaa aagctgacat cgaggagctc   1380

ccaacgctgc tgtcgcctcc gctggcagca gccgctcccg gattagactc gcaggctgtt   1440

agggcagggc cttcgccacg ggcttccgca cagcggcgtg cagtcctcag ctcggccggc   1500

gcggtctccg acggcgctgg ctccgcgtac ttccccagcg gcgagggcgc gaggtcctca   1560

cacgggcagc accttggcga ggccggcgcc gcggcccagg cgacccagtg cgaggcgcag   1620

cgcggtgccg ccgccccagg gcagcagccc aaccagcgcg gccagcagcg cggccacctg   1680

cgcgcccgcg cccagcaccg tgagcagcgt gctgcgaagg cccagcgcgg cgaacagcgt   1740

ggcgcccagc gctgccatgt agagcagcgc gggccgggac ggcgcttctt cgcagcgcag   1800

caggcgtccg cacgccgcgc cgccccgcag cagcgcgctt cccgccaacg ccagcgccga   1860

gcccagtgac cagagcagcg cgaacttgcg cgcgcgcagc agcaacaccg gtgcgtagag   1920

cgcggctagg ccgaaacaca gtgcagccag cagcaggcac ccgccgcccg ccgccagccg   1980

ctgcccgcgc gtcacgctcg ggaggcacgt caggccggcc gctgccgact ccgcagggct   2040

ccgcgcccac gtccagcgca agcccgcgcg gcccagccac tcctccgccg gccggtcccc   2100

gggctcctcc gccttctccg cggcgagcag cggctccgcg gccgccgggc cgccagcttt   2160

cccctgcgcc aggtactcct gcagctggcg gtggaggtcc gccatcttgg acaaggcggt   2220

ggcagaaagg aaaagctgcg gctcacttcc ggccctccgc tgaagcggtt cggtcttcgg   2280

gcggcaattg gtcggcgacg gcgaaagggg cagggcctgc ggcgctcgcg gaagtgccgc   2340

ggtgcctgct ctgcggactt ttgtggtgtc cccaagtacc gtggtcgcag gtgctgcctg   2400

tccgcttgca gtcgccctcc cagcgcctga ccctcttcct tgttcggagt aggcgccctt   2460

gcggtctggc taagtcctgc cagcattaat agttggaagg caggggtggg tgtggttcta   2520

aaggggcaca agaagtgacc cttttgctga cggaaatgtc ttatggcctc actgcgtcta   2580

ccgtggcggt gatattgtgc tagttttgca acatggagga atgggtaaag ggtacacaga   2640

atctctcttg tttcttacaa ctgaacacaa acagtgatct caaaataaaa atttaatttt   2700

taaaaaagtt cagacctgtg taactcaggt gggttttttg gggaaagttg cgttctgatt   2760

agttacctca cttgtagtaa tagtgaccat cctgatcatt taccatgggg ttgataaagg   2820

aagggttgac acccagcacc ctcaacctgc ttctctattc tgttctcagt ttcggccaca   2880

ggcctggcaa catccttgac tccttcgcgc cccttgtcca agactcgg                2928


<210>  8338
<211>  184
<212>  PRT
<213>  Homosapiens

<400>  8338

Met Thr Lys Ser Gln Phe Ser Glu Arg Val Pro Ser Pro Ala Gln Lys 
1               5                   10                  15      


Ala Asp Ile Glu Glu Leu Pro Thr Leu Leu Ser Pro Pro Leu Ala Ala 
            20                  25                  30          


Ala Ala Pro Gly Leu Asp Ser Gln Ala Val Arg Ala Gly Pro Ser Pro 
        35                  40                  45              


Arg Ala Ser Ala Gln Arg Arg Ala Val Leu Ser Ser Ala Gly Ala Val 
    50                  55                  60                  


Ser Asp Gly Ala Gly Ser Ala Tyr Phe Pro Ser Gly Glu Gly Ala Arg 
65                  70                  75                  80  


Ser Ser His Gly Gln His Leu Gly Glu Ala Gly Ala Ala Ala Gln Ala 
                85                  90                  95      


Thr Gln Cys Glu Ala Gln Arg Gly Ala Ala Ala Pro Gly Gln Gln Pro 
            100                 105                 110         


Asn Gln Arg Gly Gln Gln Arg Gly His Leu Arg Ala Arg Ala Gln His 
        115                 120                 125             


Arg Glu Gln Arg Ala Ala Lys Ala Gln Arg Gly Glu Gln Arg Gly Ala 
    130                 135                 140                 


Gln Arg Cys His Val Glu Gln Arg Gly Pro Gly Arg Arg Phe Phe Ala 
145                 150                 155                 160 


Ala Gln Gln Ala Ser Ala Arg Arg Ala Ala Pro Gln Gln Arg Ala Ser 
                165                 170                 175     


Arg Gln Arg Gln Arg Arg Ala Gln 
            180                 


<210>  8339
<211>  2817
<212>  DNA
<213>  Homosapiens

<400>  8339
tgaacttttt taaaaattaa atttttattt tgagatcact gtttgtgttc agttgtaaga     60

aacaagagag attctgtgta ccctttaccc attcctccat gttgcaaaac tagcacaata    120

tcaccgccac ggtagacgca gtgaggccat aagacatttc cgtcagcaaa agggtcactt    180

cttgtgcccc tttagaacca cacccacccc tgccttccaa ctattaatgc tggcaggact    240

tagccagacc gcaagggcgc ctactccgaa caaggaagag ggtcaggcgc tgggagggcg    300

actgcaagcg gacaggcagc acctgcgacc acggtacttg gggacaccac aaaagtccgc    360

agagcaggca ccgcggcact tccgcgagcg ccgcaggccc tgcccctttc gccgtcgccg    420

accaattgcc gcccgaagac cgaaccgctt cagcggaggg ccggaagtga gccgcagctt    480

ttcctttctg ccaccgcctt gtccaagatg gcggacctcc accgccagct gcaggagtac    540

ctggcgcagg ggaaagctgg cggcccggcg gccgcggagc cgctgctcgc cgcggagaag    600

gcggaggagc ccggggaccg gccggcggag gagtggctgg gccgcgcggg cttgcgctgg    660

acgtgggcgc ggagccctgc ggagtcggca gcggccggcc tgacgtgcct cccgagcgtg    720

acgcgcgggc agcggctggc ggcgggcggc gggtgcctgc tgctggctgc actgtgtttc    780

ggcctagccg cgctctacgc accggtgttg ctgctgcgcg cgcgcaagtt cgcgctgctc    840

tggtcactgg gctcggcgct ggcgttggcg ggaagcgcgc tgctgcgggg cggcgcggcg    900

tgcggacgcc tgctgcgctg cgaagaagcg ccgtcccggc ccgcgctgct ctacatggca    960

gcgctgggcg ccacgctgtt cgccgcgctg ggccttcgca gcacgctgct cacggtgctg   1020

ggcgcgggcg cgcaggtggc cgcgctgctg gccgcgctgg ttgggctgct gccctggggc   1080

ggcggcaccg cgctgcgcct cgcactgggt cgcctgggcc gcggcgccgg cctcgccaag   1140

gtgctgcccg tgtgaggacc tcgcgccctc gccgctgggg aagtacgcgg agccagcgcc   1200

gtcggagacc gcgccggccg agctgaggac tgcacgccgc tgtgcggaag cccgtggcga   1260

aggccctgcc ctaacagcct gcgagtctaa tccgggagcg gctgctgcca gcggaggcga   1320

cagcagcgtt gggagctcct cgatgtcagc tttttgtgct ggacttggca cacgctctga   1380

aaactgagat tttgtcattg aactggtgac aggatgtgag acggttatta gaagttgctt   1440

tcgaagtaac tgtggtctta ggttcggctg agtaaagaaa aaggattttt cttcgagtta   1500

gctgctcttg tgatttttct caggctgttt tgtcatttta aaatccagtg gtagatgtag   1560

cttagcgacg gtagtttttt gttttggcta tactaagact tggaaattat tctctccagt   1620

gtcagcgaat ccagaagggt atcagattaa acaccgaatt cagccactgg acttttaaaa   1680

gtacttaaga tggtttatct cgggtttttt cttcagttaa caaaatcata aatatggtgc   1740

cttataacat gaaaggaaaa ttagttgtgt atttcacgac gaaagcgacg gaccaaaaga   1800

aatttcctgc cccaagaagc atgggatcca ggaaggggcg cgtagatgct taacggtctc   1860

ttcggaaatc ctgcaaatag aaagataatt ctagatccgg aatacctgta tctggtggaa   1920

accatggatt tctacaagct cgaattattc ctcattgtat agcctgcttt gtaaactagt   1980

ttacaatttg caggctgatc ttaagatttt tttatatcta attgctgctg ccttcatttt   2040

aggttcagca gttactttta actaccttaa tttattgcca gaaggtatga gcctaacatt   2100

ctgatgagtc cagaaaacta cgttttgtca gtagcaatac actaggaagt aaaatatatt   2160

tagaatttaa acattgtgtg ccagtggtcc tcgcgcttga ctgcacatca gttacttgaa   2220

gagccacacc tcagatcaat gcagtcagaa cctgggaagt aggtcccaga catcaggacc   2280

tttttaaagc tccccaagtg attctacgtt ccccaagttt gaggaccact tttctgtgca   2340

ttggcttgca caatttgaaa gtaatgcttt tcctgagctg gatcccagtg ttgccttaac   2400

agggtgtctg tcgtgccgca gtagagcact gctgcttcct ccaaccccaa aatttatgtt   2460

cctaagtaag tcaggtccct aagccccgtc ccaagaagtg acacaagtgg ccaacatcca   2520

cactgtaggc ttgcaggcta cccgccctga gatttggtaa agaacactgc cttgttcccc   2580

atcagtaaac aaggttacct acctcaggag gctgcttgtg agagagcaaa tgcagtatct   2640

tcagaatgat ttattttttt aattaattgt aaagacttgt gccattggct gctctttcta   2700

gtcccctaaa tttctgttct agttttaaat ttctctagaa cttgcaatag ttgggggttt   2760

tataatgatg ttttacaatg tttatttctt aaataaaaac ttaaaaattc aacattt      2817


<210>  8340
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  8340

Met Ala Asp Leu His Arg Gln Leu Gln Glu Tyr Leu Ala Gln Gly Lys 
1               5                   10                  15      


Ala Gly Gly Pro Ala Ala Ala Glu Pro Leu Leu Ala Ala Glu Lys Ala 
            20                  25                  30          


Glu Glu Pro Gly Asp Arg Pro Ala Glu Glu Trp Leu Gly Arg Ala Gly 
        35                  40                  45              


Leu Arg Trp Thr Trp Ala Arg Ser Pro Ala Glu Ser Ala Ala Ala Gly 
    50                  55                  60                  


Leu Thr Cys Leu Pro Ser Val Thr Arg Gly Gln Arg Leu Ala Ala Gly 
65                  70                  75                  80  


Gly Gly Cys Leu Leu Leu Ala Ala Leu Cys Phe Gly Leu Ala Ala Leu 
                85                  90                  95      


Tyr Ala Pro Val Leu Leu Leu Arg Ala Arg Lys Phe Ala Leu Leu Trp 
            100                 105                 110         


Ser Leu Gly Ser Ala Leu Ala Leu Ala Gly Ser Ala Leu Leu Arg Gly 
        115                 120                 125             


Gly Ala Ala Cys Gly Arg Leu Leu Arg Cys Glu Glu Ala Pro Ser Arg 
    130                 135                 140                 


Pro Ala Leu Leu Tyr Met Ala Ala Leu Gly Ala Thr Leu Phe Ala Ala 
145                 150                 155                 160 


Leu Gly Leu Arg Ser Thr Leu Leu Thr Val Leu Gly Ala Gly Ala Gln 
                165                 170                 175     


Val Ala Ala Leu Leu Ala Ala Leu Val Gly Leu Leu Pro Trp Gly Gly 
            180                 185                 190         


Gly Thr Ala Leu Arg Leu Ala Leu Gly Arg Leu Gly Arg Gly Ala Gly 
        195                 200                 205             


Leu Ala Lys Val Leu Pro Val 
    210                 215 


<210>  8341
<211>  2854
<212>  DNA
<213>  Homosapiens

<400>  8341
tgaacttttt taaaaattaa atttttattt tgagatcact gtttgtgttc agttgtaaga     60

aacaagagag attctgtgta ccctttaccc attcctccat gttgcaaaac tagcacaata    120

tcaccgccac ggtagacgca gtgaggccat aagacatttc cgtcagcaaa agggtcactt    180

cttgtgcccc tttagaacca cacccacccc tgccttccaa ctattaatgc tggcaggact    240

tagccagacc gcaagggcgc ctactccgaa caaggaagag ggtcaggcgc tgggagggcg    300

actgcaagcg gacaggcagc acctgcgacc acggtacttg gggacaccac aaaagtccgc    360

agagcaggca ccgcggcact tccgcgagcg ccgcaggccc tgcccctttc gccgtcgccg    420

accaattgcc gcccgaagac cgaaccgctt cagcggaggg ccggaagtga gccgcagctt    480

ttcctttctg ccaccgcctt gtccaagatg gcggacctcc accgccagct gcaggagtac    540

ctggcgcagg ggaaagctgg cggcccggcg gccgcggagc cgctgctcgc cgcggagaag    600

gcggaggagc ccggggaccg gccggcggag gagtggctgg gccgcgcggg cttgcgctgg    660

acgtgggcgc ggagccctgc ggagtcggca gcggccggcc tgacgtgcct cccgagcgtg    720

acgcgcgggc agcggctggc ggcgggcggc gggtgcctgc tgctggctgc actgtgtttc    780

ggcctagccg cgctctacgc accggtgttg ctgctgcgcg cgcgcaagtt cgcgctgctc    840

tggtcactgg gctcggcgct ggcgttggcg ggaagcgcgc tgctgcgggg cggcgcggcg    900

tgcggacgcc tgctgcgctg cgaagaagcg ccgtcccggc ccgcgctgct ctacatggca    960

gcgctgggcg ccacgctgtt cgccgcgctg ggccttcgca gcacgctgct cacggtgctg   1020

ggcgcgggcg cgcaggtggc cgcgctgctg gccgcgctgg ttgggctgct gccctggggc   1080

ggcggcaccg cgctgcgcct cgcactgggt cgcctgggcc gcggcgccgg cctcgccaag   1140

gtgctgcccg tgtgaggacc tcgcgccctc gccgctgggg aagtacgcgg agccagcgcc   1200

gtcggagacc gcgccggccg agctgaggac tgcacgccgc tgtgcggaag cccgtggcga   1260

aggccctgcc ctaacagcct gcgagtctaa tccgggagcg gctgctgcca gcggaggcga   1320

cagcagcgtt gggagctcct cgatgtcagc tttttgtgct ggacttggca cacgctctga   1380

aaactgagat tttgtcattg aactggtgac aggatgtgag acggttatta gaagttgctt   1440

tcgaagtaac tgtggtctta ggttcggctg agtaaagaaa aaggattttt cttcgagtta   1500

gctgctcttg tgatttttct caggctgttt tgtcatttta aaatccagtg gtagatgtag   1560

cttagcgacg gtagtttttt gttttggcta tactaagact tggaaattat tctctccagt   1620

gtcagcgaat ccagaagggt atcagattaa acaccgaatt cagccactgg acttttaaaa   1680

gtacttaaga tggtttatct cgggtttttt cttcagttaa caaaatcata aatatggtgc   1740

cttataacat gaaaggaaaa ttagttgtgt atttcacgac gaaagcgacg gaccaaaaga   1800

aatttcctgc cccaagaagc atgggatcca ggaaggggcg cgtagatgct taacggtctc   1860

ttcggaaatc ctgcaaatag aaagataatt ctagatccgg aatacctgta tctggtggaa   1920

accatggatt tctacaagct cgaattattc ctcattgtat agcctgcttt gtaaactagt   1980

ttacaatttg caggctgatc ttaagatttt tttatatcta attgctgctg ccttcatttt   2040

aggttcagca gttactttta actaccttaa tttattgcca gaaggtatga gcctaacatt   2100

ctgatgagtc cagaaaacta cgttttgtca gtagcaatac actaggaagt aaaatatatt   2160

tagaatttaa acattgtgtg ccagtggtcc tcgcgcttga ctgcacatca gttacttgaa   2220

gagccacacc tcagatcaat gcagtcagaa cctgggaagt aggtcccaga catcaggacc   2280

tttttaaagc tccccaagtg attctacgtt ccccaagttt gaggaccact tttctgtgca   2340

ttggcttgca caatttgaaa gtaatgcttt tcctgagctg gatcccagtg ttgccttaac   2400

agggtgtctg tcgtgccgca gtagagcact gctgcttcct ccaaccccaa aatttatgtt   2460

cctaagtaag tcaggtccct aagccccgtc ccaagaagtg acacaagtgg ccaacatcca   2520

cactgtaggc ttgcaggcta cccgccctga gatttggtaa agaacactgc cttgttcccc   2580

atcagtaaac aaggttacct acctcaggag gctgcttgtg agagagcaaa tgcagtatct   2640

tcagaatgat ttattttttt aattaattgt aaagacttgt gccattggct gctctttcta   2700

gtcccctaaa tttctgttct agttttaaat ttctctagaa cttgcaatag ttgggggttt   2760

tataatgatg ttttacaatg tttatttctt aaataaaaac ttaaaaattc aacatttctc   2820

agctggtggc tcacacctgt aatcccagca tttt                               2854


<210>  8342
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  8342

Met Ala Asp Leu His Arg Gln Leu Gln Glu Tyr Leu Ala Gln Gly Lys 
1               5                   10                  15      


Ala Gly Gly Pro Ala Ala Ala Glu Pro Leu Leu Ala Ala Glu Lys Ala 
            20                  25                  30          


Glu Glu Pro Gly Asp Arg Pro Ala Glu Glu Trp Leu Gly Arg Ala Gly 
        35                  40                  45              


Leu Arg Trp Thr Trp Ala Arg Ser Pro Ala Glu Ser Ala Ala Ala Gly 
    50                  55                  60                  


Leu Thr Cys Leu Pro Ser Val Thr Arg Gly Gln Arg Leu Ala Ala Gly 
65                  70                  75                  80  


Gly Gly Cys Leu Leu Leu Ala Ala Leu Cys Phe Gly Leu Ala Ala Leu 
                85                  90                  95      


Tyr Ala Pro Val Leu Leu Leu Arg Ala Arg Lys Phe Ala Leu Leu Trp 
            100                 105                 110         


Ser Leu Gly Ser Ala Leu Ala Leu Ala Gly Ser Ala Leu Leu Arg Gly 
        115                 120                 125             


Gly Ala Ala Cys Gly Arg Leu Leu Arg Cys Glu Glu Ala Pro Ser Arg 
    130                 135                 140                 


Pro Ala Leu Leu Tyr Met Ala Ala Leu Gly Ala Thr Leu Phe Ala Ala 
145                 150                 155                 160 


Leu Gly Leu Arg Ser Thr Leu Leu Thr Val Leu Gly Ala Gly Ala Gln 
                165                 170                 175     


Val Ala Ala Leu Leu Ala Ala Leu Val Gly Leu Leu Pro Trp Gly Gly 
            180                 185                 190         


Gly Thr Ala Leu Arg Leu Ala Leu Gly Arg Leu Gly Arg Gly Ala Gly 
        195                 200                 205             


Leu Ala Lys Val Leu Pro Val 
    210                 215 


<210>  8343
<211>  2711
<212>  DNA
<213>  Homosapiens

<400>  8343
ttgaattttt aagtttttat ttaagaaata aacattgtaa aacatcatta taaaaccccc     60

aactattgca agttctagag aaatttaaaa ctagaacaga aatttagggg actagaaaga    120

gcagccaatg gcacaagtct ttacaattaa ttaaaaaaat aaatcattct gaagatactg    180

catttgctct ctcacaagca gcctcctgag gtaggtaacc ttgtttactg atggggaaca    240

aggcagtgtt ctttaccaaa tctcagggcg ggtagcctgc aagcctacag tgtggatgtt    300

ggccacttgt gtcacttctt gggacggggc ttagggacct gacttactta ggaacataaa    360

ttttggggtt ggaggaagca gcagtgctct actgcggcac gacagacacc ctgttaaggc    420

aacactggga tccagctcag gaaaagcatt actttcaaat tgtgcaagcc aatgcacaga    480

aaagtgtggc tcttcaagta actgatgtgc agtcaagcgc gaggaccact ggcacacaat    540

gtttaaattc taaatatatt ttacttccta gtgtattgct actgacaaaa cgtagttttc    600

tggactcatc agaatgttag gctcatacct tctggcaata aattaaggta gttaaaagta    660

actgctgaac ctaaaatgaa ggcagcagca attagatata aaaaaatctt aagatcagcc    720

tgcaaattgt aaactagttt acaaagcagg ctatacaatg aggaataatt cgagcttgta    780

gaaatccatg gtttccacca gatacaggta ttccggatct agaattatct ttctatttgc    840

aggatttccg aagagaccgt taagcatcta cgcgcccctt cctggatccc atgcttcttg    900

gggcaggaaa tttcttttgg tccgtcgctt tcgtcgtgaa atacacaact aattttcctt    960

tcatgttata aggcaccata tttatgattt tgttaactga agaaaaaacc cgagataaac   1020

catcttaagt acttttaaaa gtccagtggc tgaattcggt gtttaatctg atacccttct   1080

ggattcgctg acactggaga gaataatttc caagtcttag tatagccaaa acaaaaaact   1140

accgtcgcta agctacatct accactggat tttaaaatga caaaacagcc tgagaaaaat   1200

cacaagagca gctaactcga agaaaaatcc tttttcttta ctcagccgaa cctaagacca   1260

cagttacttc gaaagcaact tctaataacc gtctcacatc ctgtcaccag ttcaatgaca   1320

aaatctcagt tttcagagcg tgtgccaagt ccagcacaaa aagctgacat cgaggagctc   1380

ccaacgctgc tgtcgcctcc gctggcagca gccgctcccg gattagactc gcaggctgtt   1440

agggcagggc cttcgccacg ggcttccgca cagcggcgtg cagtcctcag ctcggccggc   1500

gcggtctccg acggcgctgg ctccgcgtac ttccccagcg gcgagggcgc gaggtcctca   1560

cacgggcagc accttggcga ggccggcgcc gcggcccagg cgacccagtg cgaggcgcag   1620

cgcggtgccg ccgccccagg gcagcagccc aaccagcgcg gccagcagcg cggccacctg   1680

cgcgcccgcg cccagcaccg tgagcagcgt gctgcgaagg cccagcgcgg cgaacagcgt   1740

ggcgcccagc gctgccatgt agagcagcgc gggccgggac ggcgcttctt cgcagcgcag   1800

caggcgtccg cacgccgcgc cgccccgcag cagcgcgctt cccgccaacg ccagcgccga   1860

gcccagtgac cagagcagcg cgaacttgcg cgcgcgcagc agcaacaccg gtgcgtagag   1920

cgcggctagg ccgaaacaca gtgcagccag cagcaggcac ccgccgcccg ccgccagccg   1980

ctgcccgcgc gtcacgctcg ggaggcacgt caggccggcc gctgccgact ccgcagggct   2040

ccgcgcccac gtccagcgca agcccgcgcg gcccagccac tcctccgccg gccggtcccc   2100

gggctcctcc gccttctccg cggcgagcag cggctccgcg gccgccgggc cgccagcttt   2160

cccctgcgcc aggtactcct gcagctggcg gtggaggtcc gccatcttgg acaaggcggt   2220

ggcagaaagg aaaagctgcg gctcacttcc ggccctccgc tgaagcggtt cggtcttcgg   2280

gcggcaattg gtcggcgacg gcgaaagggg cagggcctgc ggcgctcgcg gaagtgccgc   2340

ggtgcctgct ctgcggactt ttgtggtgtc cccaagtacc gtggtcgcag gtgctgcctg   2400

tccgcttgca gtcgccctcc cagcgcctga ccctcttcct tgttcggagt aggcgccctt   2460

gcggtctggc taagtcctgc cagcattaat agttggaagg caggggtggg tgtggttcta   2520

aaggggcaca agaagtgacc cttttgctga cggaaatgtc ttatggcctc actgcgtcta   2580

ccgtggcggt gatattgtgc tagttttgca acatggagga atgggtaaag ggtacacaga   2640

atctctcttg tttcttacaa ctgaacacaa acagtgatct caaaataaaa atttaatttt   2700

taaaaaagtt c                                                        2711


<210>  8344
<211>  184
<212>  PRT
<213>  Homosapiens

<400>  8344

Met Thr Lys Ser Gln Phe Ser Glu Arg Val Pro Ser Pro Ala Gln Lys 
1               5                   10                  15      


Ala Asp Ile Glu Glu Leu Pro Thr Leu Leu Ser Pro Pro Leu Ala Ala 
            20                  25                  30          


Ala Ala Pro Gly Leu Asp Ser Gln Ala Val Arg Ala Gly Pro Ser Pro 
        35                  40                  45              


Arg Ala Ser Ala Gln Arg Arg Ala Val Leu Ser Ser Ala Gly Ala Val 
    50                  55                  60                  


Ser Asp Gly Ala Gly Ser Ala Tyr Phe Pro Ser Gly Glu Gly Ala Arg 
65                  70                  75                  80  


Ser Ser His Gly Gln His Leu Gly Glu Ala Gly Ala Ala Ala Gln Ala 
                85                  90                  95      


Thr Gln Cys Glu Ala Gln Arg Gly Ala Ala Ala Pro Gly Gln Gln Pro 
            100                 105                 110         


Asn Gln Arg Gly Gln Gln Arg Gly His Leu Arg Ala Arg Ala Gln His 
        115                 120                 125             


Arg Glu Gln Arg Ala Ala Lys Ala Gln Arg Gly Glu Gln Arg Gly Ala 
    130                 135                 140                 


Gln Arg Cys His Val Glu Gln Arg Gly Pro Gly Arg Arg Phe Phe Ala 
145                 150                 155                 160 


Ala Gln Gln Ala Ser Ala Arg Arg Ala Ala Pro Gln Gln Arg Ala Ser 
                165                 170                 175     


Arg Gln Arg Gln Arg Arg Ala Gln 
            180                 


<210>  8345
<211>  4387
<212>  DNA
<213>  Homosapiens

<400>  8345
attcagcctc ctccctcatc tggcacccct ctcctcggac cccagccttt tccaggacaa     60

ggtccaatgt ctcagattcc tcaaggtttt caacagcccc atccatctca gcagatgcca    120

atgaacatgg ctcaaatggg gcctccaggt ccacagggac agtttaggcc tcctggaccc    180

cagggacaaa tgggaccaca aggtcctcca ctgcatcagg gaggtggggg gccacaagga    240

ttcatgggac cacaggggcc ccagggcccg ccccaggggt tgccacggcc tcaggacatg    300

catgggcccc aaggaatgca gaggcatcct ggacctcatg gccctttggg acctcaaggg    360

ccacctggac cacaaggtag ttctggtcct caaggtcata tgggtcctca gggtccacct    420

ggcccacagg gtcacatagg cccccaaggc ccgcctggcc ctcagggtca cttgggccca    480

caggggcctc cgggtactca aggtatgcag ggaccacctg gtcccagagg aatgcaaggg    540

cctcctcatc ctcatgggat ccaaggcgga ccagggtctc aagggatcca aggtcctgtg    600

tctcagggac ctctgatggg attgaatcca agaggaatgc aggggcctcc aggcccccgg    660

gagaaccagg gtcctgctcc ccaagggatg attatgggcc acccgcctca agagatgaga    720

ggacctcacc ctccaggtgg actactggga cacggccctc aggaaatgag aggtcctcag    780

gagatccgag gcatgcaggg gcctccaccc caaggatcaa tgctgggacc tccccaggaa    840

ttgcgagggc ctccaggctc acaaagtcag caggggccgc cccagggctc tttaggacct    900

ccaccccagg gtggcatgca aggacccccc ggacctcagg gacagcagaa cccagcaaga    960

gggccacatc catctcaagg gccaatacca ttccagcaac agaaaacgcc tctgctaggt   1020

gatgggcccc gggccccctt caaccaggaa ggacagagca caggcccccc acccctgata   1080

ccaggcctag ggcagcaggg agcacaaggt cgcattcccc ctctgaaccc cggacaagga   1140

cctggcccca acaaaggtga ctcccgcggc cctccaaacc atcacatggg cccgatgtca   1200

gagaggcggc atgagcagag cggcgggcct gagcatgggc ccgagagggg gcctttccgg   1260

ggtggccagg actgcagggg tccccctgat aggcgtggcc ctcacccaga cttccccgat   1320

gacttcagca gaccagatga cttccaccct gacaagcgct ttggccaccg gttacgtgaa   1380

tttgaggggc gaggaggacc tttaccgcaa gaagagaagt ggaggcgagg gggccctggg   1440

cctccgtttc cccctgatca cagggaattc agcgaggggg atggccgggg tgcagcccga   1500

ggccctccgg gggcatggga aggccgcagg cccggagatg aacgtttccc ccgggatccc   1560

gaggacccac gttttcgagg gcgcagagaa gaaagtttca gaagaggagc cccgccgagg   1620

catgagggcc gtgctccccc cagaggaagg gatggttttc ctggtcctga agactttggt   1680

ccagaggaga attttgatgc ttctgaggaa gcggcccgag gacgagatct cagaggtcga   1740

ggtcggggta ccccacgagg aggaaggaag ggtttacttc ccactcctga cgagttccct   1800

cgctttgaag gagggcggaa gccagattcc tgggatggaa acagagagcc tgggccaggt   1860

catgaacatt ttcgtgatac tccccgccct gatcatcccc ctcacgacgg tcattcccca   1920

gccagcagag aacgctcctc ttctctccaa ggcatggaca tggcatccct acctccccga   1980

aagcgcccct ggcatgatgg cccaggcact tctgagcaca gagagatgga ggccccagga   2040

ggcccttctg aagaccgagg aggcaaaggc cgagggggcc caggacctgc tcagagagtg   2100

cccaaatctg ggcgttccag ctccttagac ggagagcacc acgatggata ccacagagat   2160

gaaccttttg ggggccctcc aggcagtggc accccttctc gagggggccg gagtggcagt   2220

aactggggta gagggagtaa catgaactct ggcccgccga ggcgaggagc ttcacggggt   2280

ggtggaaggg gtcggtagaa gctggaactg agtaccctga ggcctctctg gacagtatgt   2340

aagaacttct tgtggactca ccaagagaaa caaaaggaag cctgcaccat tgtagccctg   2400

aactcttttc tgggcacctg aatcccagga accctcaatg aggtcttcaa gatgaagaga   2460

ctgctgccag ctaccagcct ggctggccct gtcctgtcca ccctcattgc cccaactccc   2520

atgttgtttt gtgaagataa aagctgggat ctttttcttt tttttaagtc tcacaagaca   2580

tggggcatct ccacaaattt aagttcctgt ccatttggaa atttgtttct atgtgtacag   2640

tttgtcagag aaaaacaaag tttttgtatg aatacagaat gtgatttacg caagaattga   2700

cagaaaacta gttgtgaagt gcttgcctta aggaaacctt tggtttccat cgcatcccat   2760

ctgccaagga atgcacggtt gttgctgatg ttcatgagca tattaaccac taggttatct   2820

aaattaatct cagctgtgaa ctttgtgttt ttcaacacat tctgtcacac catttttgtg   2880

acagaaaaat acttgaaaat tattctaatg tagtttgtag taggttcaaa tttttattca   2940

gacatgctct gacagatgga aaattgtact ctgaagagaa aatgcaatct tctggatgtc   3000

caacgaggga gcttcccctt ggaagcatct cctaagaatc acagtttagg tttgaatcgc   3060

cttgttatga tgaggagagg aacttgatgt tagtcagaaa taaagtcaca tgccctttag   3120

ataacttgaa atcacacatg gagttgataa ggaatggacc aaaataggtc ctcaaacaat   3180

tttgcaacac ttaattaagt tttcctctct tcctcttcca tactatgtgg aaataccagt   3240

gttacggcag ggcgtacttc taactcacag taagccagat agatcttgtc catggcaaat   3300

tccttgttta aaataaacat accatttagc ccagtttgga ttggaagcca aaaattcagt   3360

ttgttatata ccccatgata ctttctatac tgacctttat tttggtttta catggaagct   3420

tttattaaaa ggactgtcct atggccacct taacatttca ttacattggc agcttcagtt   3480

ttggcatcag tcaaatttat ttggcaaatt tagtggtgct ggaagtttct ttttttcttt   3540

tccttttttg acagagtctt gctctgtcac ccagccagga gtgcagtggt gcaatcacgg   3600

ctcacttcag ctttgaccct gcctcagcct ccctagtagc taggactaca ggcatatgcc   3660

accatgccca gctaattttt tgtgtgtgtg ttttttgtag agatggagtt tcaccacttt   3720

gtctatgctg gtttcaaact cctgggctca agcggtccac ctgctgtggc ctcccaaagt   3780

gctgggattg cagatctgag ccacagtacc tggccgctgg tgctggaagt ttcaatggtt   3840

gcttagaaaa ggcatactga tatagtttaa caggatatga aaatttaact ggttctctat   3900

gaatgtaaaa aacagcaaaa gctaattgat ttctgtggag tgagaaaatg tcagccatat   3960

acactgcttt tcagtgttag aatctagaga ctattttttt tttaactttg aaattacagc   4020

ttatttaatc agcgctccac cataaacatg ctattaggag gctcaagatt gctttaggtt   4080

atgggtattt cttcactcac ccccaactgg tatagcttaa agagagagaa actgtaatca   4140

aatttcatga agctaaaacc ggatccagag accaaaccca tatcaagatt agactttttt   4200

tccctgagat tctagtggaa aaattttcat tattttgggc tttaacttta gaaacatagt   4260

atctcagtaa gcagataacc agatcacatt taaaaatttt cattttacct tgaagctcta   4320

ctggacttga cagatcacat tttgagagtg aattcattta aacaataaac ctctacatta   4380

tacttat                                                             4387


<210>  8346
<211>  743
<212>  PRT
<213>  Homosapiens

<400>  8346

Met Ser Gln Ile Pro Gln Gly Phe Gln Gln Pro His Pro Ser Gln Gln 
1               5                   10                  15      


Met Pro Met Asn Met Ala Gln Met Gly Pro Pro Gly Pro Gln Gly Gln 
            20                  25                  30          


Phe Arg Pro Pro Gly Pro Gln Gly Gln Met Gly Pro Gln Gly Pro Pro 
        35                  40                  45              


Leu His Gln Gly Gly Gly Gly Pro Gln Gly Phe Met Gly Pro Gln Gly 
    50                  55                  60                  


Pro Gln Gly Pro Pro Gln Gly Leu Pro Arg Pro Gln Asp Met His Gly 
65                  70                  75                  80  


Pro Gln Gly Met Gln Arg His Pro Gly Pro His Gly Pro Leu Gly Pro 
                85                  90                  95      


Gln Gly Pro Pro Gly Pro Gln Gly Ser Ser Gly Pro Gln Gly His Met 
            100                 105                 110         


Gly Pro Gln Gly Pro Pro Gly Pro Gln Gly His Ile Gly Pro Gln Gly 
        115                 120                 125             


Pro Pro Gly Pro Gln Gly His Leu Gly Pro Gln Gly Pro Pro Gly Thr 
    130                 135                 140                 


Gln Gly Met Gln Gly Pro Pro Gly Pro Arg Gly Met Gln Gly Pro Pro 
145                 150                 155                 160 


His Pro His Gly Ile Gln Gly Gly Pro Gly Ser Gln Gly Ile Gln Gly 
                165                 170                 175     


Pro Val Ser Gln Gly Pro Leu Met Gly Leu Asn Pro Arg Gly Met Gln 
            180                 185                 190         


Gly Pro Pro Gly Pro Arg Glu Asn Gln Gly Pro Ala Pro Gln Gly Met 
        195                 200                 205             


Ile Met Gly His Pro Pro Gln Glu Met Arg Gly Pro His Pro Pro Gly 
    210                 215                 220                 


Gly Leu Leu Gly His Gly Pro Gln Glu Met Arg Gly Pro Gln Glu Ile 
225                 230                 235                 240 


Arg Gly Met Gln Gly Pro Pro Pro Gln Gly Ser Met Leu Gly Pro Pro 
                245                 250                 255     


Gln Glu Leu Arg Gly Pro Pro Gly Ser Gln Ser Gln Gln Gly Pro Pro 
            260                 265                 270         


Gln Gly Ser Leu Gly Pro Pro Pro Gln Gly Gly Met Gln Gly Pro Pro 
        275                 280                 285             


Gly Pro Gln Gly Gln Gln Asn Pro Ala Arg Gly Pro His Pro Ser Gln 
    290                 295                 300                 


Gly Pro Ile Pro Phe Gln Gln Gln Lys Thr Pro Leu Leu Gly Asp Gly 
305                 310                 315                 320 


Pro Arg Ala Pro Phe Asn Gln Glu Gly Gln Ser Thr Gly Pro Pro Pro 
                325                 330                 335     


Leu Ile Pro Gly Leu Gly Gln Gln Gly Ala Gln Gly Arg Ile Pro Pro 
            340                 345                 350         


Leu Asn Pro Gly Gln Gly Pro Gly Pro Asn Lys Gly Asp Ser Arg Gly 
        355                 360                 365             


Pro Pro Asn His His Met Gly Pro Met Ser Glu Arg Arg His Glu Gln 
    370                 375                 380                 


Ser Gly Gly Pro Glu His Gly Pro Glu Arg Gly Pro Phe Arg Gly Gly 
385                 390                 395                 400 


Gln Asp Cys Arg Gly Pro Pro Asp Arg Arg Gly Pro His Pro Asp Phe 
                405                 410                 415     


Pro Asp Asp Phe Ser Arg Pro Asp Asp Phe His Pro Asp Lys Arg Phe 
            420                 425                 430         


Gly His Arg Leu Arg Glu Phe Glu Gly Arg Gly Gly Pro Leu Pro Gln 
        435                 440                 445             


Glu Glu Lys Trp Arg Arg Gly Gly Pro Gly Pro Pro Phe Pro Pro Asp 
    450                 455                 460                 


His Arg Glu Phe Ser Glu Gly Asp Gly Arg Gly Ala Ala Arg Gly Pro 
465                 470                 475                 480 


Pro Gly Ala Trp Glu Gly Arg Arg Pro Gly Asp Glu Arg Phe Pro Arg 
                485                 490                 495     


Asp Pro Glu Asp Pro Arg Phe Arg Gly Arg Arg Glu Glu Ser Phe Arg 
            500                 505                 510         


Arg Gly Ala Pro Pro Arg His Glu Gly Arg Ala Pro Pro Arg Gly Arg 
        515                 520                 525             


Asp Gly Phe Pro Gly Pro Glu Asp Phe Gly Pro Glu Glu Asn Phe Asp 
    530                 535                 540                 


Ala Ser Glu Glu Ala Ala Arg Gly Arg Asp Leu Arg Gly Arg Gly Arg 
545                 550                 555                 560 


Gly Thr Pro Arg Gly Gly Arg Lys Gly Leu Leu Pro Thr Pro Asp Glu 
                565                 570                 575     


Phe Pro Arg Phe Glu Gly Gly Arg Lys Pro Asp Ser Trp Asp Gly Asn 
            580                 585                 590         


Arg Glu Pro Gly Pro Gly His Glu His Phe Arg Asp Thr Pro Arg Pro 
        595                 600                 605             


Asp His Pro Pro His Asp Gly His Ser Pro Ala Ser Arg Glu Arg Ser 
    610                 615                 620                 


Ser Ser Leu Gln Gly Met Asp Met Ala Ser Leu Pro Pro Arg Lys Arg 
625                 630                 635                 640 


Pro Trp His Asp Gly Pro Gly Thr Ser Glu His Arg Glu Met Glu Ala 
                645                 650                 655     


Pro Gly Gly Pro Ser Glu Asp Arg Gly Gly Lys Gly Arg Gly Gly Pro 
            660                 665                 670         


Gly Pro Ala Gln Arg Val Pro Lys Ser Gly Arg Ser Ser Ser Leu Asp 
        675                 680                 685             


Gly Glu His His Asp Gly Tyr His Arg Asp Glu Pro Phe Gly Gly Pro 
    690                 695                 700                 


Pro Gly Ser Gly Thr Pro Ser Arg Gly Gly Arg Ser Gly Ser Asn Trp 
705                 710                 715                 720 


Gly Arg Gly Ser Asn Met Asn Ser Gly Pro Pro Arg Arg Gly Ala Ser 
                725                 730                 735     


Arg Gly Gly Gly Arg Gly Arg 
            740             


<210>  8347
<211>  3285
<212>  DNA
<213>  Homosapiens

<400>  8347
attcagcctc ctccctcatc tggcacccct ctcctcggac cccagccttt tccaggacaa     60

ggtccaatgt ctcagattcc tcaaggtttt caacagcccc atccatctca gcagatgcca    120

atgaacatgg ctcaaatggg gcctccaggt ccacagggac agtttaggcc tcctggaccc    180

cagggacaaa tgggaccaca aggtcctcca ctgcatcagg gaggtggggg gccacaagga    240

ttcatgggac cacaggggcc ccagggcccg ccccaggggt tgccacggcc tcaggacatg    300

catgggcccc aaggaatgca gaggcatcct ggacctcatg gccctttggg acctcaaggg    360

ccacctggac cacaaggtag ttctggtcct caaggtcata tgggtcctca gggtccacct    420

ggcccacagg gtcacatagg cccccaaggc ccgcctggcc ctcagggtca cttgggccca    480

caggggcctc cgggtactca aggtatgcag ggaccacctg gtcccagagg aatgcaaggg    540

cctcctcatc ctcatgggat ccaaggcgga ccagggtctc aagggatcca aggtcctgtg    600

tctcagggac ctctgatggg attgaatcca agaggaatgc aggggcctcc aggcccccgg    660

gagaaccagg gtcctgctcc ccaagggatg attatgggcc acccgcctca agagatgaga    720

ggacctcacc ctccaggtgg actactggga cacggccctc aggaaatgag aggtcctcag    780

gagatccgag gcatgcaggg gcctccaccc caaggatcaa tgctgggacc tccccaggaa    840

ttgcgagggc ctccaggctc acaaagtcag caggggccgc cccagggctc tttaggacct    900

ccaccccagg gtggcatgca aggacccccc ggacctcagg gacagcagaa cccagcaaga    960

gggccacatc catctcaagg gccaatacca ttccagcaac agaaaacgcc tctgctaggt   1020

gatgggcccc gggccccctt caaccaggaa ggacagagca caggcccccc acccctgata   1080

ccaggcctag ggcagcaggg agcacaaggt cgcatccccc tgataggcgt ggccctcacc   1140

cagacttccc cgatgacttc agcagaccag atgacttcca ccctgacaag cgctttggcc   1200

accggttacg tgaatttgag gggcgaggag gacctttacc gcaagaagag aagtggaggc   1260

gagggggccc tgggcctccg tttccccctg atcacaggga attcagcgag ggggatggcc   1320

ggggtgcagc ccgaggccct ccgggggcat gggaaggccg caggcccgga gatgaacgtt   1380

tcccccggga tcccgaggac ccacgttttc gagggcgcag agaagaaagt ttcagaagag   1440

gagccccgcc gaggcatgag ggccgtgctc cccccagagg aagggatggt tttcctggtc   1500

ctgaagactt tggtccagag gagaattttg atgcttctga ggaagcggcc cgaggacgag   1560

atctcagagg tcgaggtcgg ggtaccccac gaggaggaag gaagggttta cttcccactc   1620

ctgacgagtt ccctcgcttt gaaggagggc ggaagccaga ttcctgggat ggaaacagag   1680

agcctgggcc aggtcatgaa cattttcgtg atactccccg ccctgatcat ccccctcacg   1740

acggtcattc cccagccagc agagaacgct cctcttctct ccaaggcatg gacatggcat   1800

ccctacctcc ccgaaagcgc ccctggcatg atggcccagg cacttctgag cacagagaga   1860

tggaggcccc aggaggccct tctgaagacc gaggaggcaa aggccgaggg ggcccaggac   1920

ctgctcagag agtgcccaaa tctgggcgtt ccagctcctt agacggagag caccacgatg   1980

gataccacag agatgaacct tttgggggcc ctccaggcag tggcacccct tctcgagggg   2040

gccggagtgg cagtaactgg ggtagaggga gtaacatgaa ctctggcccg ccgaggcgag   2100

gagcttcacg gggtggtgga aggggtcggt agaagctgga actgagtacc ctgaggcctc   2160

tctggacagt atgtaagaac ttcttgtgga ctcaccaaga gaaacaaaag gaagcctgca   2220

ccattgtagc cctgaactct tttctgggca cctgaatccc aggaaccctc aatgaggtct   2280

tcaagatgaa gagactgctg ccagctacca gcctggctgg ccctgtcctg tccaccctca   2340

ttgccccaac tcccatgttg ttttgtgaag ataaaagctg ggatcttttt ctttttttta   2400

agtctcacaa gacatggggc atctccacaa atttaagttc ctgtccattt ggaaatttgt   2460

ttctatgtgt acagtttgtc agagaaaaac aaagtttttg tatgaataca gaatgtgatt   2520

tacgcaagaa ttgacagaaa actagttgtg aagtgcttgc cttaaggaaa cctttggttt   2580

ccatcgcatc ccatctgcca aggaatgcac ggttgttgct gatgttcatg agcatattaa   2640

ccactaggtt atctaaatta atctcagctg tgaactttgt gtttttcaac acattctgtc   2700

acaccatttt tgtgacagaa aaatacttga aaattattct aatgtagttt gtagtaggtt   2760

caaattttta ttcagacatg ctctgacaga tggaaaattg tactctgaag agaaaatgca   2820

atcttctgga tgtccaacga gggagcttcc ccttggaagc atctcctaag aatcacagtt   2880

taggtttgaa tcgccttgtt atgatgagga gaggaacttg atgttagtca gaaataaagt   2940

cacatgccct ttagataact tgaaatcaca catggagttg ataaggaatg gaccaaaata   3000

ggtcctcaaa caattttgca acacttaatt aagttttcct ctcttcctct tccatactat   3060

gtggaaatac cagtgttacg gcagggcgta cttctaactc acagtaagcc agatagatct   3120

tgtccatggc aaattccttg tttaaaataa acataccatt tagcccagtt tggattggaa   3180

gccaaaaatt cagtttgtta tataccccat gatactttct atactgacct ttattttggt   3240

tttacatgga agcttttatt aaaaggactg tcctatggcc acctt                   3285


<210>  8348
<211>  631
<212>  PRT
<213>  Homosapiens

<400>  8348

Met Ser Gln Ile Pro Gln Gly Phe Gln Gln Pro His Pro Ser Gln Gln 
1               5                   10                  15      


Met Pro Met Asn Met Ala Gln Met Gly Pro Pro Gly Pro Gln Gly Gln 
            20                  25                  30          


Phe Arg Pro Pro Gly Pro Gln Gly Gln Met Gly Pro Gln Gly Pro Pro 
        35                  40                  45              


Leu His Gln Gly Gly Gly Gly Pro Gln Gly Phe Met Gly Pro Gln Gly 
    50                  55                  60                  


Pro Gln Gly Pro Pro Gln Gly Leu Pro Arg Pro Gln Asp Met His Gly 
65                  70                  75                  80  


Pro Gln Gly Met Gln Arg His Pro Gly Pro His Gly Pro Leu Gly Pro 
                85                  90                  95      


Gln Gly Pro Pro Gly Pro Gln Gly Ser Ser Gly Pro Gln Gly His Met 
            100                 105                 110         


Gly Pro Gln Gly Pro Pro Gly Pro Gln Gly His Ile Gly Pro Gln Gly 
        115                 120                 125             


Pro Pro Gly Pro Gln Gly His Leu Gly Pro Gln Gly Pro Pro Gly Thr 
    130                 135                 140                 


Gln Gly Met Gln Gly Pro Pro Gly Pro Arg Gly Met Gln Gly Pro Pro 
145                 150                 155                 160 


His Pro His Gly Ile Gln Gly Gly Pro Gly Ser Gln Gly Ile Gln Gly 
                165                 170                 175     


Pro Val Ser Gln Gly Pro Leu Met Gly Leu Asn Pro Arg Gly Met Gln 
            180                 185                 190         


Gly Pro Pro Gly Pro Arg Glu Asn Gln Gly Pro Ala Pro Gln Gly Met 
        195                 200                 205             


Ile Met Gly His Pro Pro Gln Glu Met Arg Gly Pro His Pro Pro Gly 
    210                 215                 220                 


Gly Leu Leu Gly His Gly Pro Gln Glu Met Arg Gly Pro Gln Glu Ile 
225                 230                 235                 240 


Arg Gly Met Gln Gly Pro Pro Pro Gln Gly Ser Met Leu Gly Pro Pro 
                245                 250                 255     


Gln Glu Leu Arg Gly Pro Pro Gly Ser Gln Ser Gln Gln Gly Pro Pro 
            260                 265                 270         


Gln Gly Ser Leu Gly Pro Pro Pro Gln Gly Gly Met Gln Gly Pro Pro 
        275                 280                 285             


Gly Pro Gln Gly Gln Gln Asn Pro Ala Arg Gly Pro His Pro Ser Gln 
    290                 295                 300                 


Gly Pro Ile Pro Phe Gln Gln Gln Lys Thr Pro Leu Leu Gly Asp Gly 
305                 310                 315                 320 


Pro Arg Ala Pro Phe Asn Gln Glu Gly Gln Ser Thr Gly Pro Pro Pro 
                325                 330                 335     


Leu Ile Pro Gly Leu Gly Gln Gln Gly Ala Gln Gly Arg Ile Pro Leu 
            340                 345                 350         


Ile Gly Val Ala Leu Thr Gln Thr Ser Pro Met Thr Ser Ala Asp Gln 
        355                 360                 365             


Met Thr Ser Thr Leu Thr Ser Ala Leu Ala Thr Gly Tyr Val Asn Leu 
    370                 375                 380                 


Arg Gly Glu Glu Asp Leu Tyr Arg Lys Lys Arg Ser Gly Gly Glu Gly 
385                 390                 395                 400 


Ala Leu Gly Leu Arg Phe Pro Leu Ile Thr Gly Asn Ser Ala Arg Gly 
                405                 410                 415     


Met Ala Gly Val Gln Pro Glu Ala Leu Arg Gly His Gly Lys Ala Ala 
            420                 425                 430         


Gly Pro Glu Met Asn Val Ser Pro Gly Ile Pro Arg Thr His Val Phe 
        435                 440                 445             


Glu Gly Ala Glu Lys Lys Val Ser Glu Glu Glu Pro Arg Arg Gly Met 
    450                 455                 460                 


Arg Ala Val Leu Pro Pro Glu Glu Gly Met Val Phe Leu Val Leu Lys 
465                 470                 475                 480 


Thr Leu Val Gln Arg Arg Ile Leu Met Leu Leu Arg Lys Arg Pro Glu 
                485                 490                 495     


Asp Glu Ile Ser Glu Val Glu Val Gly Val Pro His Glu Glu Glu Gly 
            500                 505                 510         


Arg Val Tyr Phe Pro Leu Leu Thr Ser Ser Leu Ala Leu Lys Glu Gly 
        515                 520                 525             


Gly Ser Gln Ile Pro Gly Met Glu Thr Glu Ser Leu Gly Gln Val Met 
    530                 535                 540                 


Asn Ile Phe Val Ile Leu Pro Ala Leu Ile Ile Pro Leu Thr Thr Val 
545                 550                 555                 560 


Ile Pro Gln Pro Ala Glu Asn Ala Pro Leu Leu Ser Lys Ala Trp Thr 
                565                 570                 575     


Trp His Pro Tyr Leu Pro Glu Ser Ala Pro Gly Met Met Ala Gln Ala 
            580                 585                 590         


Leu Leu Ser Thr Glu Arg Trp Arg Pro Gln Glu Ala Leu Leu Lys Thr 
        595                 600                 605             


Glu Glu Ala Lys Ala Glu Gly Ala Gln Asp Leu Leu Arg Glu Cys Pro 
    610                 615                 620                 


Asn Leu Gly Val Pro Ala Pro 
625                 630     


<210>  8349
<211>  655
<212>  DNA
<213>  Homosapiens

<400>  8349
aggcatggac atggcatccc tacctccccg aaagcgcccc tggcatgatg tgcccaaatc     60

tgggcgttcc agctccttag acggagagca ccacgatgga taccacagag atgaaccttt    120

tgggggccct ccaggcagtg gcaccccttc tcgagggggc cggagtggca gtaactgggg    180

tagagggagt aacatgaact ctggcccgcc gaggcgagga gcttcacggg gtggtggaag    240

gggtcggtag aagctggaac tgagtaccct gaggcctctc tggacagtat gtaagaactt    300

cttgtggact caccaagaga aacaaaagga agcctgcacc attgtagccc tgaactcttt    360

tctgggcacc tgaatcccag gaaccctcaa tgaggtcttc aagatgaaga gactgctgcc    420

agctaccagc ctggctggcc ctgtcctgtc caccctcatt gccccaactc ccatgttgtt    480

ttgtgaagat aaaagctggg atctttttct tttttttaag tctcacaaga catggggcat    540

ctccacaaat ttaagttcct gtccatttgg aaatttgttt ctatgtgtac agtttgtcag    600

agaaaaacaa agtttttgta tgaatacaga atgtgattta cgcaagaatt gacag         655


<210>  8350
<211>  81
<212>  PRT
<213>  Homosapiens

<400>  8350

Met Asp Met Ala Ser Leu Pro Pro Arg Lys Arg Pro Trp His Asp Val 
1               5                   10                  15      


Pro Lys Ser Gly Arg Ser Ser Ser Leu Asp Gly Glu His His Asp Gly 
            20                  25                  30          


Tyr His Arg Asp Glu Pro Phe Gly Gly Pro Pro Gly Ser Gly Thr Pro 
        35                  40                  45              


Ser Arg Gly Gly Arg Ser Gly Ser Asn Trp Gly Arg Gly Ser Asn Met 
    50                  55                  60                  


Asn Ser Gly Pro Pro Arg Arg Gly Ala Ser Arg Gly Gly Gly Arg Gly 
65                  70                  75                  80  


Arg 
    


<210>  8351
<211>  2537
<212>  DNA
<213>  Homosapiens

<400>  8351
attcagcctc ctccctcatc tggcacccct ctcctcggac cccagccttt tccaggacaa     60

ggtccaatgt ctcagattcc tcaaggtttt caacagcccc atccatctca gcagatgcca    120

atgaacatgg ctcaaatggg gcctccaggt ccacagggac agtttaggcc tcctggaccc    180

cagggacaaa tgggaccaca aggtcctcca ctgcatcagg gaggtggggg gccacaagga    240

ttcatgggac cacaggggcc ccagggcccg ccccaggggt tgccacggcc tcaggacatg    300

catgggcccc aaggaatgca gaggcatcct ggacctcatg gccctttggg acctcaaggg    360

ccacctggac cacaaggtag ttctggtcct caaggtcata tgggtcctca gggtccacct    420

ggcccacagg gtcacatagg cccccaaggc ccgcctggcc ctcagggtca cttgggccca    480

caggggcctc cgggtactca aggtatgcag ggaccacctg gtcccagagg aatgcaaggg    540

cctcctcatc ctcatgggat ccaaggcgga ccagggtctc aagggatcca aggtcctgtg    600

tctcagggac ctctgatggg attgaatcca agaggaatgc aggggcctcc aggcccccgg    660

gagaaccagg gtcctgctcc ccaagggatg attatgggcc acccgcctca agagatgaga    720

ggacctcacc ctccaggtgg actactggga cacggccctc aggaaatgag aggtcctcag    780

gagatccgag gcatgcaggg gcctccaccc caaggatcaa tgctgggacc tccccaggaa    840

ttgcgagggc ctccaggctc acaaagtcag caggggccgc cccagggctc tttaggacct    900

ccaccccagg gtggcatgca aggacccccc ggacctcagg gacagcagaa cccagcaaga    960

gggccacatc catctcaagg gccaatacca ttccagcaac agaaaacgcc tctgctaggt   1020

gatgggcccc gggccccctt caaccaggaa ggacagagca caggcccccc acccctgata   1080

ccaggcctag ggcagcaggg agcacaaggt cgcatccccc tgataggcgt ggccctcacc   1140

cagacttccc cgatgacttc agcagaccag atgacttcca ccctgacaag cgctttggcc   1200

accggttacg tgaatttgag gggcgaggag gacctttacc gcaagaagag aagtggaggc   1260

gagggggccc tgggcctccg tttccccctg atcacaggga attcagcgag ggggatggcc   1320

ggggtgcagc ccgaggccct ccgggggcat gggaaggccg caggcccgga gatgaacgtt   1380

tcccccggga tcccgaggac ccacgttttc gagggcgcag agaagaaagt ttcagaagag   1440

gagccccgcc gaggcatgag ggccgtgctc cccccagagg aagggatggt tttcctggtc   1500

ctgaagactt tggtccagag gagaattttg atgcttctga ggaagcggcc cgaggacgag   1560

atctcagagg tcgaggtcgg ggtaccccac gaggaggaag gaagggttta cttcccactc   1620

ctgacgagtt ccctcgcttt gaaggagggc ggaagccaga ttcctgggat ggaaacagag   1680

agcctgggcc aggtcatgaa cattttcgtg atactccccg ccctgatcat ccccctcacg   1740

acggtcattc cccagccagc agagaacgct cctcttctct ccaaggcatg gacatggcat   1800

ccctacctcc ccgaaagcgc ccctggcatg atggcccagg cacttctgag cacagagaga   1860

tggaggcccc aggaggccct tctgaagacc gaggaggcaa aggccgaggg ggcccaggac   1920

ctgctcagag agtgcccaaa tctgggcgtt ccagctcctt agacggagag caccacgatg   1980

gataccacag agatgaacct tttgggggcc ctccaggcag tggcacccct tctcgagggg   2040

gccggagtgg cagtaactgg ggtagaggga gtaacatgaa ctctggcccg ccgaggcgag   2100

gagcttcacg gggtggtgga aggggtcggt agaagctgga actgagtacc ctgaggcctc   2160

tctggacagt atgtaagaac ttcttgtgga ctcaccaaga gaaacaaaag gaagcctgca   2220

ccattgtagc cctgaactct tttctgggca cctgaatccc aggaaccctc aatgaggtct   2280

tcaagatgaa gagactgctg ccagctacca gcctggctgg ccctgtcctg tccaccctca   2340

ttgccccaac tcccatgttg ttttgtgaag ataaaagctg ggatcttttt ctttttttta   2400

agtctcacaa gacatggggc atctccacaa atttaagttc ctgtccattt ggaaatttgt   2460

ttctatgtgt acagtttgtc agagaaaaac aaagtttttg tatgaataca gaatgtgatt   2520

tacgcaagaa ttgacag                                                  2537


<210>  8352
<211>  631
<212>  PRT
<213>  Homosapiens

<400>  8352

Met Ser Gln Ile Pro Gln Gly Phe Gln Gln Pro His Pro Ser Gln Gln 
1               5                   10                  15      


Met Pro Met Asn Met Ala Gln Met Gly Pro Pro Gly Pro Gln Gly Gln 
            20                  25                  30          


Phe Arg Pro Pro Gly Pro Gln Gly Gln Met Gly Pro Gln Gly Pro Pro 
        35                  40                  45              


Leu His Gln Gly Gly Gly Gly Pro Gln Gly Phe Met Gly Pro Gln Gly 
    50                  55                  60                  


Pro Gln Gly Pro Pro Gln Gly Leu Pro Arg Pro Gln Asp Met His Gly 
65                  70                  75                  80  


Pro Gln Gly Met Gln Arg His Pro Gly Pro His Gly Pro Leu Gly Pro 
                85                  90                  95      


Gln Gly Pro Pro Gly Pro Gln Gly Ser Ser Gly Pro Gln Gly His Met 
            100                 105                 110         


Gly Pro Gln Gly Pro Pro Gly Pro Gln Gly His Ile Gly Pro Gln Gly 
        115                 120                 125             


Pro Pro Gly Pro Gln Gly His Leu Gly Pro Gln Gly Pro Pro Gly Thr 
    130                 135                 140                 


Gln Gly Met Gln Gly Pro Pro Gly Pro Arg Gly Met Gln Gly Pro Pro 
145                 150                 155                 160 


His Pro His Gly Ile Gln Gly Gly Pro Gly Ser Gln Gly Ile Gln Gly 
                165                 170                 175     


Pro Val Ser Gln Gly Pro Leu Met Gly Leu Asn Pro Arg Gly Met Gln 
            180                 185                 190         


Gly Pro Pro Gly Pro Arg Glu Asn Gln Gly Pro Ala Pro Gln Gly Met 
        195                 200                 205             


Ile Met Gly His Pro Pro Gln Glu Met Arg Gly Pro His Pro Pro Gly 
    210                 215                 220                 


Gly Leu Leu Gly His Gly Pro Gln Glu Met Arg Gly Pro Gln Glu Ile 
225                 230                 235                 240 


Arg Gly Met Gln Gly Pro Pro Pro Gln Gly Ser Met Leu Gly Pro Pro 
                245                 250                 255     


Gln Glu Leu Arg Gly Pro Pro Gly Ser Gln Ser Gln Gln Gly Pro Pro 
            260                 265                 270         


Gln Gly Ser Leu Gly Pro Pro Pro Gln Gly Gly Met Gln Gly Pro Pro 
        275                 280                 285             


Gly Pro Gln Gly Gln Gln Asn Pro Ala Arg Gly Pro His Pro Ser Gln 
    290                 295                 300                 


Gly Pro Ile Pro Phe Gln Gln Gln Lys Thr Pro Leu Leu Gly Asp Gly 
305                 310                 315                 320 


Pro Arg Ala Pro Phe Asn Gln Glu Gly Gln Ser Thr Gly Pro Pro Pro 
                325                 330                 335     


Leu Ile Pro Gly Leu Gly Gln Gln Gly Ala Gln Gly Arg Ile Pro Leu 
            340                 345                 350         


Ile Gly Val Ala Leu Thr Gln Thr Ser Pro Met Thr Ser Ala Asp Gln 
        355                 360                 365             


Met Thr Ser Thr Leu Thr Ser Ala Leu Ala Thr Gly Tyr Val Asn Leu 
    370                 375                 380                 


Arg Gly Glu Glu Asp Leu Tyr Arg Lys Lys Arg Ser Gly Gly Glu Gly 
385                 390                 395                 400 


Ala Leu Gly Leu Arg Phe Pro Leu Ile Thr Gly Asn Ser Ala Arg Gly 
                405                 410                 415     


Met Ala Gly Val Gln Pro Glu Ala Leu Arg Gly His Gly Lys Ala Ala 
            420                 425                 430         


Gly Pro Glu Met Asn Val Ser Pro Gly Ile Pro Arg Thr His Val Phe 
        435                 440                 445             


Glu Gly Ala Glu Lys Lys Val Ser Glu Glu Glu Pro Arg Arg Gly Met 
    450                 455                 460                 


Arg Ala Val Leu Pro Pro Glu Glu Gly Met Val Phe Leu Val Leu Lys 
465                 470                 475                 480 


Thr Leu Val Gln Arg Arg Ile Leu Met Leu Leu Arg Lys Arg Pro Glu 
                485                 490                 495     


Asp Glu Ile Ser Glu Val Glu Val Gly Val Pro His Glu Glu Glu Gly 
            500                 505                 510         


Arg Val Tyr Phe Pro Leu Leu Thr Ser Ser Leu Ala Leu Lys Glu Gly 
        515                 520                 525             


Gly Ser Gln Ile Pro Gly Met Glu Thr Glu Ser Leu Gly Gln Val Met 
    530                 535                 540                 


Asn Ile Phe Val Ile Leu Pro Ala Leu Ile Ile Pro Leu Thr Thr Val 
545                 550                 555                 560 


Ile Pro Gln Pro Ala Glu Asn Ala Pro Leu Leu Ser Lys Ala Trp Thr 
                565                 570                 575     


Trp His Pro Tyr Leu Pro Glu Ser Ala Pro Gly Met Met Ala Gln Ala 
            580                 585                 590         


Leu Leu Ser Thr Glu Arg Trp Arg Pro Gln Glu Ala Leu Leu Lys Thr 
        595                 600                 605             


Glu Glu Ala Lys Ala Glu Gly Ala Gln Asp Leu Leu Arg Glu Cys Pro 
    610                 615                 620                 


Asn Leu Gly Val Pro Ala Pro 
625                 630     


<210>  8353
<211>  515
<212>  DNA
<213>  Homosapiens

<400>  8353
ctagtatggt catttgagcc tgagcagaga atatgcccaa gaggatgcca agccagactc     60

cagatcatcc cttcgtgagc catctccatc ccacccactt ccttctctac cccaacatgc    120

cagaataaca aagaaccatc agaccctcca ctggcaaaaa gtccttcatg aacaggatgc    180

caggccacag ctgtggcttc tttcttatga cctcggaaga cttgaagctc ttcttttagg    240

tttctgatat caaaaagttt acagagatga tcacgtgatg ctgtgagtag ccaattgcca    300

ttgaggttta atttcacttc cattactgtg tttttatggg catgaagtgt tgcaagactc    360

tgcccagtct tgggatccca gaacttgatt ggctgttgac tatctttact tcctgaaaca    420

actaaccctt tggttggatg ccagtctaca catttcacat cagcaccatg ccctcggaga    480

attctttcct catggcaacg aagaaagtcc cagat                               515


<210>  8354
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  8354

Met Pro Lys Arg Met Pro Ser Gln Thr Pro Asp His Pro Phe Val Ser 
1               5                   10                  15      


His Leu His Pro Thr His Phe Leu Leu Tyr Pro Asn Met Pro Glu 
            20                  25                  30      


<210>  8355
<211>  502
<212>  DNA
<213>  Homosapiens

<400>  8355
ctattccaag ctggatttac agaactgaaa actgcaagca gtctctgata taggatatat     60

gaacacttag aaaagctaca aaactatcat gtctgcacac attcacgtgc tctcttcaca    120

aaatacacta ctttttcaca taaatcttac atacccaaca tgccagaata acaaagaacc    180

atcagaccct ccactggcaa aaagtccttc atgaacagga tgccaggcca cagctgtggc    240

ttctttctta tgacctcgga agacttgaag ctcttctttt aggtttctga tatcaaaaag    300

tttacagaga tgatcacgtg atgctgtgag tagccaattg ccattgaggt ttaatttcac    360

ttccattact gtgtttttat gggcatgaag tgttgcaaga ctctgcccag tcttgggatc    420

ccagaacttg attggctgtt gactatcttt acttcctgaa acaactaacc ctttggttgg    480

atgccagtct acacatttca ca                                             502


<210>  8356
<211>  41
<212>  PRT
<213>  Homosapiens

<400>  8356

Met Ser Ala His Ile His Val Leu Ser Ser Gln Asn Thr Leu Leu Phe 
1               5                   10                  15      


His Ile Asn Leu Thr Tyr Pro Thr Cys Gln Asn Asn Lys Glu Pro Ser 
            20                  25                  30          


Asp Pro Pro Leu Ala Lys Ser Pro Ser 
        35                  40      


<210>  8357
<211>  429
<212>  DNA
<213>  Homosapiens

<400>  8357
aatatatgta tagtacattt gccccaagat tcctacctta ctgctgacac attactcatc     60

caagatggca aaaagaaata acattttacc agagctatca cttgttcatc caacttcctt    120

atcactaaat ggagttaggg attaattctt gtgcttaagg ttggtcagca ggataaaacc    180

tgttcttacc ccccaaaaaa ctaaatgctg tcctgatgaa acagtctagg caccggccgg    240

gcgcggtggc tcacgcgcat agccctttta aaggacttca aaaagaccaa ttctaagttc    300

atatctgttg aattttttac atctaaaaac actaaaaaat catgacagct ttgtttaaac    360

aagtagtcat atttatagat tgcttataaa tataaaagcc tatatatact actgtcataa    420

cagtggctg                                                            429


<210>  8358
<211>  41
<212>  PRT
<213>  Homosapiens

<400>  8358

Asn Ser Leu Gly Thr Gly Arg Ala Arg Trp Leu Thr Arg Ile Ala Leu 
1               5                   10                  15      


Leu Lys Asp Phe Lys Lys Thr Asn Ser Lys Phe Ile Ser Val Glu Phe 
            20                  25                  30          


Phe Thr Ser Lys Asn Thr Lys Lys Ser 
        35                  40      


<210>  8359
<211>  662
<212>  DNA
<213>  Homosapiens

<400>  8359
gaggatgggt gctacgggtg ttgggtgtca aattattatt cagagctttt cccttatgtt     60

caagagtcag cagagatcgt tgtcttggtt gaatcgttaa gtttctcaca gtttttcaga    120

gctttagctg tagcatataa tgttgatgtt ttgtagacag gaaagactct tgagatactt    180

taatgtgtat ttcagcccat atttcaagcc agtatcttcc atcacatttg cttcaacact    240

cctgacttgg cacattttgt ttgggtttat ccacagtact gtatgactgt agcttttgta    300

agaataggga acctgtcaca ttgagggagt ttactcacta taaaggtcat aatattgtat    360

aacttcagaa cgagacagag actttgagat gatcatgtct gagttatttt atggatgagc    420

tccatgatgc caagggtgga agtgacatgt tcaaagcaaa ataggttcag agccaggact    480

agaatcttat catttgactc ccagcctaat gccacactta tgttgaatct ttcctcactc    540

tgttgcccag gctggagtgc agtggtgtga tcttggctca ctgcaacctc cgcctctcgg    600

gttcaagtga gtctcctgcc tcagcctcct gagtaactgg gattacaggc atgtgtcacc    660

at                                                                   662


<210>  8360
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  8360

Met Ser Ser Met Met Pro Arg Val Glu Val Thr Cys Ser Lys Gln Asn 
1               5                   10                  15      


Arg Phe Arg Ala Arg Thr Arg Ile Leu Ser Phe Asp Ser Gln Pro Asn 
            20                  25                  30          


Ala Thr Leu Met Leu Asn Leu Ser Ser Leu Cys Cys Pro Gly Trp Ser 
        35                  40                  45              


Ala Val Val 
    50      


<210>  8361
<211>  3133
<212>  DNA
<213>  Homosapiens

<400>  8361
ggcccatagg ggaagatggc ggctgctcct ttggaggagc gggattgaga ggatcggggt     60

ggggagacca aacaagagag acatttctgg ctctgaaggc gaacgcttcg ctggccattt    120

aggagctctg ctcaaagcca gacgtatcct agaaggaaaa catcaccatg gctacagaaa    180

ttggttctcc tcctcgtttt ttccatatgc caaggttcca gcaccaggca cctcgacagc    240

tgttttataa gcgacctgat tttgcacaac agcaagcaat gcaacagctt acttttgatg    300

gaaaacgaat gagaaaagct gtgaaccgaa aaaccataga ctacaatcca tctgtaatta    360

agtatttgga gaacagaata tggcaaagag accagagaga tatgcgggca attcagcctg    420

atgcaggtta ttacaatgat ctggtcccac ctataggaat gttgaataat cctatgaatg    480

cagtaacaac aaaatttgtt cggacatcaa caaataaagt aaagtgtcct gtatttgttg    540

ttaggtggac tccagaagga agacgcttgg tcactggagc ttctagtggg gagtttaccc    600

tgtggaatgg actcactttc aattttgaaa caatattaca ggctcacgac agcccagtga    660

gggccatgac gtggtcacat aatgacatgt ggatgttgac agcagaccac ggaggatatg    720

tgaaatattg gcagtcgaac atgaacaacg tcaagatgtt ccaggcacat aaggaggcga    780

ttagagaggc caggtttata cacaatatac cattttctgt agtccctatt gtcatggtta    840

aattattctc taagtgtatt ctgggtgcag agatgcatgg gctctgtcag tttctgggaa    900

actttctgca ccctataaac acaatatttt tctttgtttt cacacattca ccattttgct    960

ggcacctttc tgaagtagtg ttgtcccggt atcagccttt gcaatatgtt agagatgtac   1020

tgtctgccgc attttgcact ggttttctct tttcatttat gattaataat gtgtatacgt   1080

tattcctttt tattatctac tgtgtaagac aagaatattt cattccaaat aaagaattca   1140

gtctttaatt atgcaactga ataaaatcta aagcctacag aaaacaactt cagaattcac   1200

acaaagtgga aaaaggctta agtgaagacc tggttggctt ggttatgcca cgacttccaa   1260

aggaaagtat aggactaaaa ccctcacaga taactggatg tggcaaacat taacggagta   1320

atgaatgggt tcttcaagct ttgcagctgt aagcagatca ttgtcaagaa gactctagga   1380

cttttcttct gattcactgt tgataacatc acttatgcaa atgtatacaa taagtggagt   1440

ttaaaatatt ttcagtgagt tgtatatttt tacacatcag tgaggtatgt atagtaaaac   1500

tgggggaaaa agttccaaat acaagcctga agaattgctg cagcctcaga ataaagctaa   1560

gcagcattct ttaaggttgt gccacccatg tgtgggagga ggttgacatc tttatggaaa   1620

catcatccac tgtagtcatt tgttcatact ttcagaatct taacagaaat tgttggatga   1680

acatgcttct gctttgtaga ttttgcctta gtgtcatgcc catacattga gtttacacag   1740

ctggtccttc ataggattcc aaagttcaag ggagttttta gagttagttg agaaacttga   1800

tgatctttca ctgctgggaa aaactgactc cttcttgcag cagattcttt ggctttacac   1860

acaagtctga atgtccttat tttaaagttt tcctcaaagg tgcaacattc atggaatagc   1920

ttgccaggaa gatgtgaaac ttttctacag acctttgaaa tggatgagaa acattgtatg   1980

tagggatgtt tagcaatcag tcttttaata gacagcccac attgtttcag cttatttcat   2040

gaagtgtctg aggcagaagc tgatgataat tttgggagca gtattcgtgt gtgatttaaa   2100

agactgcagg aatactgcaa aaatagaatc catttatttt caccacttaa ggcagcttca   2160

tgtgatttcc tcgtatcata gaaaatagag aaggaacatg gatagcatta gcactaataa   2220

tacacacttg aagttctcag aatactgatg attgaaaact caaacaactg ctctgttgaa   2280

gtcttctttt gatgagatgc ctatgttagc tgacgacatt cactttaagg gcttcttcac   2340

tggattcttc cctctcctgt ttataatgca gcacagtgtt tttatttttc cctgtctgag   2400

aagcacagat tatctgttaa atgctgactt ctttcccctg ctgtgtgtct tcatgtaaca   2460

gtttctcacc cacggataat aaatttgcta catgctctga tgacggcact gttagaatct   2520

gggactttct tcgttgccat gaggaaagaa ttctccgagg tacgtgtact aacagtactg   2580

attggaatat ttaaataggg aagacatttg tggttaaatc atcacaaaac cacaatactg   2640

gcttacacct ccattcaatt ttttttacat atacacaccg tctcaggctc ttcaaaaaaa   2700

cccagcactt tctctgactc acagtcattt tgtaggtttt tactaccagt gttatctttg   2760

aatttttcag ctgtaaatta aatacaagag tgcctccccc ttacttgctt atctgtatgc   2820

atcttttagg gctgtattcc ttttccttcc ttgtagccag ggtacttgtt cccaacatat   2880

tgacactgtg gtttgattta gatagccgtc attctcctgg cagtcctttt acaatatgaa   2940

ttaaccgaca agatagaggt atcaaagcta cacttcttag tgttactatt tttgaaagca   3000

gttggttttt cagtacacca catttgtact acatggccgg cttgttacta agttcgggtg   3060

gcattgctgc ttgtttactt ttgttgattt tataattaat aaacctctat gaaattactt   3120

cattccgtaa ctg                                                      3133


<210>  8362
<211>  326
<212>  PRT
<213>  Homosapiens

<400>  8362

Met Ala Thr Glu Ile Gly Ser Pro Pro Arg Phe Phe His Met Pro Arg 
1               5                   10                  15      


Phe Gln His Gln Ala Pro Arg Gln Leu Phe Tyr Lys Arg Pro Asp Phe 
            20                  25                  30          


Ala Gln Gln Gln Ala Met Gln Gln Leu Thr Phe Asp Gly Lys Arg Met 
        35                  40                  45              


Arg Lys Ala Val Asn Arg Lys Thr Ile Asp Tyr Asn Pro Ser Val Ile 
    50                  55                  60                  


Lys Tyr Leu Glu Asn Arg Ile Trp Gln Arg Asp Gln Arg Asp Met Arg 
65                  70                  75                  80  


Ala Ile Gln Pro Asp Ala Gly Tyr Tyr Asn Asp Leu Val Pro Pro Ile 
                85                  90                  95      


Gly Met Leu Asn Asn Pro Met Asn Ala Val Thr Thr Lys Phe Val Arg 
            100                 105                 110         


Thr Ser Thr Asn Lys Val Lys Cys Pro Val Phe Val Val Arg Trp Thr 
        115                 120                 125             


Pro Glu Gly Arg Arg Leu Val Thr Gly Ala Ser Ser Gly Glu Phe Thr 
    130                 135                 140                 


Leu Trp Asn Gly Leu Thr Phe Asn Phe Glu Thr Ile Leu Gln Ala His 
145                 150                 155                 160 


Asp Ser Pro Val Arg Ala Met Thr Trp Ser His Asn Asp Met Trp Met 
                165                 170                 175     


Leu Thr Ala Asp His Gly Gly Tyr Val Lys Tyr Trp Gln Ser Asn Met 
            180                 185                 190         


Asn Asn Val Lys Met Phe Gln Ala His Lys Glu Ala Ile Arg Glu Ala 
        195                 200                 205             


Arg Phe Ile His Asn Ile Pro Phe Ser Val Val Pro Ile Val Met Val 
    210                 215                 220                 


Lys Leu Phe Ser Lys Cys Ile Leu Gly Ala Glu Met His Gly Leu Cys 
225                 230                 235                 240 


Gln Phe Leu Gly Asn Phe Leu His Pro Ile Asn Thr Ile Phe Phe Phe 
                245                 250                 255     


Val Phe Thr His Ser Pro Phe Cys Trp His Leu Ser Glu Val Val Leu 
            260                 265                 270         


Ser Arg Tyr Gln Pro Leu Gln Tyr Val Arg Asp Val Leu Ser Ala Ala 
        275                 280                 285             


Phe Cys Thr Gly Phe Leu Phe Ser Phe Met Ile Asn Asn Val Tyr Thr 
    290                 295                 300                 


Leu Phe Leu Phe Ile Ile Tyr Cys Val Arg Gln Glu Tyr Phe Ile Pro 
305                 310                 315                 320 


Asn Lys Glu Phe Ser Leu 
                325     


<210>  8363
<211>  1180
<212>  DNA
<213>  Homosapiens

<400>  8363
ggcccatagg ggaagatggc ggctgctcct ttggaggagc gggattgaga ggatcggggt     60

ggggagacca aacaagagag acatttctgg ctctgaaggc gaacgcttcg ctggccattt    120

aggagctctg ctcaaagcca gacgtatcct agaaggaaaa catcaccatg gctacagaaa    180

ttggttctcc tcctcgtttt ttccatatgc caaggttcca gcaccaggca cctcgacagc    240

tgttttataa gcgacctgat tttgcacaac agcaagcaat gcaacagctt acttttgatg    300

gaaaacgaat gagaaaagct gtgaaccgaa aaaccataga ctacaatcca tctgtaatta    360

agtatttgga gaacagaata tggcaaagag accagagaga tatgcgggca attcagcctg    420

atgcaggtta ttacaatgat ctggtcccac ctataggaat gttgaataat cctatgaatg    480

cagtaacaac aaaatttgtt cggacatcaa caaataaagt aaagtgtcct gtatttgttg    540

ttaggtggac tccagaagga agacgcttgg tcactggagc ttctagtggg gagtttaccc    600

tgtggaatgg actcactttc aattttgaaa caatattaca ggctcacgac agcccagtga    660

gggccatgac gtggtcacat aatgacatgt ggatgttgac agcagaccac ggaggatatg    720

tgaaatattg gcagtcgaac atgaacaacg tcaagatgtt ccaggcacat aaggaggcga    780

ttagagaggc caggtttata cacaatatac cattttctgt agtccctatt gtcatggtta    840

aattattctc taagtgtatt ctgggtgcag agatgcatgg gctctgtcag tttctgggaa    900

actttctgca ccctataaac acaatatttt tctttgtttt cacacattca ccattttgct    960

ggcacctttc tgaagtagtg ttgtcccggt atcagccttt gcaatatgtt agagatgtac   1020

tgtctgccgc attttgcact ggttttctct tttcatttat gattaataat gtgtatacgt   1080

tattcctttt tattatctac tgtgtaagac aagaatattt cattccaaat aaagaattca   1140

gtctttaatt atgcaactga ataaaatcta aagcctacag                         1180


<210>  8364
<211>  326
<212>  PRT
<213>  Homosapiens

<400>  8364

Met Ala Thr Glu Ile Gly Ser Pro Pro Arg Phe Phe His Met Pro Arg 
1               5                   10                  15      


Phe Gln His Gln Ala Pro Arg Gln Leu Phe Tyr Lys Arg Pro Asp Phe 
            20                  25                  30          


Ala Gln Gln Gln Ala Met Gln Gln Leu Thr Phe Asp Gly Lys Arg Met 
        35                  40                  45              


Arg Lys Ala Val Asn Arg Lys Thr Ile Asp Tyr Asn Pro Ser Val Ile 
    50                  55                  60                  


Lys Tyr Leu Glu Asn Arg Ile Trp Gln Arg Asp Gln Arg Asp Met Arg 
65                  70                  75                  80  


Ala Ile Gln Pro Asp Ala Gly Tyr Tyr Asn Asp Leu Val Pro Pro Ile 
                85                  90                  95      


Gly Met Leu Asn Asn Pro Met Asn Ala Val Thr Thr Lys Phe Val Arg 
            100                 105                 110         


Thr Ser Thr Asn Lys Val Lys Cys Pro Val Phe Val Val Arg Trp Thr 
        115                 120                 125             


Pro Glu Gly Arg Arg Leu Val Thr Gly Ala Ser Ser Gly Glu Phe Thr 
    130                 135                 140                 


Leu Trp Asn Gly Leu Thr Phe Asn Phe Glu Thr Ile Leu Gln Ala His 
145                 150                 155                 160 


Asp Ser Pro Val Arg Ala Met Thr Trp Ser His Asn Asp Met Trp Met 
                165                 170                 175     


Leu Thr Ala Asp His Gly Gly Tyr Val Lys Tyr Trp Gln Ser Asn Met 
            180                 185                 190         


Asn Asn Val Lys Met Phe Gln Ala His Lys Glu Ala Ile Arg Glu Ala 
        195                 200                 205             


Arg Phe Ile His Asn Ile Pro Phe Ser Val Val Pro Ile Val Met Val 
    210                 215                 220                 


Lys Leu Phe Ser Lys Cys Ile Leu Gly Ala Glu Met His Gly Leu Cys 
225                 230                 235                 240 


Gln Phe Leu Gly Asn Phe Leu His Pro Ile Asn Thr Ile Phe Phe Phe 
                245                 250                 255     


Val Phe Thr His Ser Pro Phe Cys Trp His Leu Ser Glu Val Val Leu 
            260                 265                 270         


Ser Arg Tyr Gln Pro Leu Gln Tyr Val Arg Asp Val Leu Ser Ala Ala 
        275                 280                 285             


Phe Cys Thr Gly Phe Leu Phe Ser Phe Met Ile Asn Asn Val Tyr Thr 
    290                 295                 300                 


Leu Phe Leu Phe Ile Ile Tyr Cys Val Arg Gln Glu Tyr Phe Ile Pro 
305                 310                 315                 320 


Asn Lys Glu Phe Ser Leu 
                325     


<210>  8365
<211>  1177
<212>  DNA
<213>  Homosapiens

<400>  8365
ctgggaggca gagggggtgg cgagccaaga ttgcaccatt gtactccagc ctaggcaaca     60

agagcgaaac tgtctcaaaa aaaaaaaaaa aaaaaaagtg aaattgctta cccaaatcta    120

cagttaactt tcgtttttta atgcttgatg aatttgcatg tcattcttgg gcagtggcca    180

tgctgtcttc tctgtattgt tccaatttgg gtatatgtgc tgccaaagtg agtactgcag    240

aattatttct tgagagaggc acttacatgt gctgattggc actaaagcag tggaatggga    300

agaagagact tggaaggcag cccagacgat ccaggcgtgt gctagatggc aactgaggag    360

cacggtgcta ccatctttac tggtgtttcc acctatgtgc caggggttct gtgagctacc    420

tgagaatact gaagtatata atgctctggc acatagttag gcactaatca gtggtattta    480

tcaaggtgat taaaagcaga tttaaaaagc agctcacagt tgggcgcggt ggctcacacc    540

tgtaatccca gcactttggg aggccgaggc gggtggatca ccagaggtca gaagttcgag    600

accagcctgg ccaacgttgt gaaaccctgt ctctactaaa aatacaaaaa ttggccactg    660

cagtggcatg attaaggttc actgcagcct caatctccca ctctccagcg atcatcccac    720

ctcagcctct tggatagctg ggaccacagg cacgagctac catgcctggc taatttattt    780

tttgtagaga cggggtttcg ccatgttgcc caggctggtc tggaatttct gacctctagc    840

agtccacctg tttccgcctc ccaaatgctg agattagagg catgagtcac tgcacccagc    900

ccgcagcctc ttttataagg gcattaatcc ccttcatgag ggatattctc tcatgactta    960

atcacctgcc aaagacccca cctcttaata ctacatcagt gatgggttca atgtatcaat   1020

tgggtgggag ggggcacatt cagaccatag catctagtca ttctggtttt attaagattt   1080

attagacctg aggcatgaaa aatagcatac tggatgggac ttcagcatcg atgagttgcc   1140

ttagtaatac tgttaataaa aagcactaaa tatgcca                            1177


<210>  8366
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  8366

Met Leu Asp Glu Phe Ala Cys His Ser Trp Ala Val Ala Met Leu Ser 
1               5                   10                  15      


Ser Leu Tyr Cys Ser Asn Leu Gly Ile Cys Ala Ala Lys Val Ser Thr 
            20                  25                  30          


Ala Glu Leu Phe Leu Glu Arg Gly Thr Tyr Met Cys 
        35                  40                  


<210>  8367
<211>  3144
<212>  DNA
<213>  Homosapiens

<400>  8367
aactagacca gaagatagta gactttatag agaaagacca gttttaccta gatactaaag     60

gaagaattaa accgctgtta gtttgaaatg cttttttttt ttttttttaa atggagatag    120

ggtcttaact cttgtccagg ctggaggagt gcagtcgtac agtcatggct cactgaagtc    180

ttgaccccgc tgcctcagcc tcccaaataa ctggggccac aggtgtgcac cacaactctc    240

agctaatttt taaaattttt tatagaggtg gggttttact atgctgtcca gactggtctt    300

aaactcctgg gctcaagtga tccccctgcc ttggcctccc aaactggtga gattacaggc    360

atgagccacc acaactggcc tgaaattctt aaaggatggg agtgtcgatg acagcacctt    420

ggcatcgttg tgcctaacct gggagacgga agaagcacgc catgggaagt gtttacactt    480

ggggacaagt gctaagtatt gtggagccca tagccccttg agatagatgg ctactttgcc    540

tttcttcttg aactgtcttg cagaatgtgg atttggggta agtggtcttg aaggattcat    600

ttagtcaccc tcaaattaag atttttactt catctttctt gggcctgcac ctccaagata    660

acaaagaaga agcaatggtc gtgccaaaga ggtccacaac caggtgtgca ctgttcactg    720

cagcccattt gctgtatgaa ctgtggttgt tgtgtgccca atgacaaggc tactaagaaa    780

ttcatcattt gaaacgtaga ggccgcagca gtcagcgatg tttctgaaat gagcatcctt    840

gacgcctgtg tacttcccag gctggatgtg aagctacatt accatgtgag ttgtgccatt    900

cacagcacag tggtgaggaa ttgagctcat gaagcaggca aggaccgaac acctccaccc    960

caacgtagac ctgcaggtgc tgccccatga cctccaccaa agcccatata aggagcggag   1020

ttgttaagga ctgaagaaaa acttctctgg agaaaaataa aattgcaatt ctacttaaaa   1080

aaattttttt ttttttttac ttcataggcc aggcttgaag ttctgaacac tttgaagtct   1140

ccaattatga gagatccagt ctaagcctct ggcctgctaa ttagcaataa gtgctttatt   1200

tggaaggagg gaaattgctt gaacctggga ggcagagggg gtggcgagcc aagattgcac   1260

cattgtactc cagcctaggc aacaagagcg aaactgtctc aaaaaaaaaa aaaaaaaaaa   1320

agtgaaattg cttacccaaa tctacagtta actttcgttt tttaatgctt gatgaatttg   1380

catgtcattc ttgggcagtg gccatgctgt cttctctgta ttgttccaat ttgggtatat   1440

gtgctgccaa agtgagtact gcagaattat ttcttgagag aggcacttac atgtgctgat   1500

tggcactaaa gcagtggaat gggaagaaga gacttggaag gcagcccaga cgatccaggc   1560

gtgtgctaga tggcaactga ggagcacggt gctaccatct ttactggtgt ttccacctat   1620

gtgccagggg ttctgtgagc tacctgagaa tactgaagta tataatgctc tggcacatag   1680

ttaggcacta atcagtggta tttatcaagg tgattaaaag cagatttaaa aagcagctca   1740

cagttgggcg cggtggctca cacctgtaat cccagcactt tgggaggccg aggcgggtgg   1800

atcaccagag gtcagaagtt cgagaccagc ctggccaacg ttgtgaaacc ctgtctctac   1860

taaaaataca aaaattggcc acgtgtggtg gcgggcacct gtaatcctag ctacttggga   1920

agctgagaca ggagaattgc ttgaacccgg gaggtggagg ttgcagtgag ccaagatcat   1980

gccattgcac tccagcctgg gcaacaagag cgagactcca tcttgaaaaa aaataaaata   2040

ataaaaagca gctcatacta gggaacttgg taaagcaacc tcatgctgtt gtaggttgaa   2100

agcctggtca gctattctgc aagacagtca aaaattgttt acagggctgg acagcatatt   2160

gctattgaaa aatagctatt aggagacctt gcacaatttg tgaaacattg ttaggctcat   2220

tgtactgtgt aaaatcagga aagaatttgg gaacatactg atacaacaaa aagataggtt   2280

gtcaaaccct cacttcacca gaaagctaaa ttaaccagat aagtctttct gaaagtttta   2340

gtgtcttagt ttgttcctgc gctgtaacag aataccttag actgggtaac ctataaataa   2400

taggaattta tttctcacag ttttggaggc tggcaaatgc aagatccagg tgctggtacg   2460

ttcagtgtct ggcaagggcg gctttctggt ccaagatggt gccttttttt ctgcatcttc   2520

catagggaat gaacactcct tatggtagaa gggatggaag gaccaggctt tttttttttt   2580

tttttttgga tacagcagga tcttgctctg tcgcccaggc tggagtgcag tggcatgatt   2640

aaggttcact gcagcctcaa tctcccactc tccagcgatc atcccacctc agcctcttgg   2700

atagctggga ccacaggcac gagctaccat gcctggctaa tttatttttt gtagagacgg   2760

ggtttcgcca tgttgcccag gctggtctgg aatttctgac ctctagcagt ccacctgttt   2820

ccgcctccca aatgctgaga ttagaggcat gagtcactgc acccagcccg cagcctcttt   2880

tataagggca ttaatcccct tcatgaggga tattctctca tgacttaatc acctgccaaa   2940

gaccccacct cttaatacta catcagtgat gggttcaatg tatcaattgg gtgggagggg   3000

gcacattcag accatagcat ctagtcattc tggttttatt aagatttatt agacctgagg   3060

catgaaaaat agcatactgg atgggacttc agcatcgatg agttgcctta gtaatactgt   3120

taataaaaag cactaaatat gcca                                          3144


<210>  8368
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  8368

Met Val Glu Gly Met Glu Gly Pro Gly Phe Phe Phe Phe Phe Phe Trp 
1               5                   10                  15      


Ile Gln Gln Asp Leu Ala Leu Ser Pro Arg Leu Glu Cys Ser Gly Met 
            20                  25                  30          


Ile Lys Val His Cys Ser Leu Asn Leu Pro Leu Ser Ser Asp His Pro 
        35                  40                  45              


Thr Ser Ala Ser Trp Ile Ala Gly Thr Thr Gly Thr Ser Tyr His Ala 
    50                  55                  60                  


Trp Leu Ile Tyr Phe Leu 
65                  70  


<210>  8369
<211>  3339
<212>  DNA
<213>  Homosapiens

<400>  8369
aactagacca gaagatagta gactttatag agaaagacca gttttaccta gatactaaag     60

gaagaattaa accgctgtta gtttgaaatg cttttttttt ttttttttaa atggagatag    120

ggtcttaact cttgtccagg ctggaggagt gcagtcgtac agtcatggct cactgaagtc    180

ttgaccccgc tgcctcagcc tcccaaataa ctggggccac aggtgtgcac cacaactctc    240

agctaatttt taaaattttt tatagaggtg gggttttact atgctgtcca gactggtctt    300

aaactcctgg gctcaagtga tccccctgcc ttggcctccc aaactggtga gattacaggc    360

atgagccacc acaactggcc tgaaattctt aaaggatggg agtgtcgatg acagcacctt    420

ggcatcgttg tgcctaacct gggagacgga agaagcacgc catgggaagt gtttacactt    480

ggggacaagt gctaagtatt gtggagccca tagccccttg agatagatgg ctactttgcc    540

tttcttcttg aactgtcttg cagaatgtgg atttggggta agtggtcttg aaggattcat    600

ttagtcaccc tcaaattaag atttttactt catctttctt gggcctgcac ctccaagata    660

acaaagaaga agcaatggtc gtgccaaaga ggtccacaac caggtgtgca ctgttcactg    720

cagcccattt gctgtatgaa ctgtggttgt tgtgtgccca atgacaaggc tactaagaaa    780

ttcatcattt gaaacgtaga ggccgcagca gtcagcgatg tttctgaaat gagcatcctt    840

gacgcctgtg tacttcccag gctggatgtg aagctacatt accatgtgag ttgtgccatt    900

cacagcacag tggtgaggaa ttgagctcat gaagcaggca aggaccgaac acctccaccc    960

caacgtagac ctgcaggtgc tgccccatga cctccaccaa agcccatata aggagcggag   1020

ttgttaagga ctgaagaaaa acttctctgg agaaaaataa aattgcaatt ctacttaaaa   1080

aaattttttt ttttttttac ttcataggcc aggcttgaag ttctgaacac tttgaagtct   1140

ccaattatga gagatccagt ctaagcctct ggcctgctaa ttagcaataa gtgctttatt   1200

tggaaggagg gagtcatcca ctcttgagcc actgcagtga agtcacttga tctcagtctg   1260

ggggaaaaca cttcaatagc taaacattct agctttgatt tttctgaagg gaatacactt   1320

gttttcaatt ttggggtttt tctttggggc acttgcttga ctctgtatga acttgtgatc   1380

caaggaaaaa ggagaaagaa cagtgagaat tgcttgaacc tgggaggcag agggggtggc   1440

gagccaagat tgcaccattg tactccagcc taggcaacaa gagcgaaact gtctcaaaaa   1500

aaaaaaaaaa aaaaaagtga aattgcttac ccaaatctac agttaacttt cgttttttaa   1560

tgcttgatga atttgcatgt cattcttggg cagtggccat gctgtcttct ctgtattgtt   1620

ccaatttggg tatatgtgct gccaaagtga gtactgcaga attatttctt gagagaggca   1680

cttacatgtg ctgattggca ctaaagcagt ggaatgggaa gaagagactt ggaaggcagc   1740

ccagacgatc caggcgtgtg ctagatggca actgaggagc acggtgctac catctttact   1800

ggtgtttcca cctatgtgcc aggggttctg tgagctacct gagaatactg aagtatataa   1860

tgctctggca catagttagg cactaatcag tggtatttat caaggtgatt aaaagcagat   1920

ttaaaaagca gctcacagtt gggcgcggtg gctcacacct gtaatcccag cactttggga   1980

ggccgaggcg ggtggatcac cagaggtcag aagttcgaga ccagcctggc caacgttgtg   2040

aaaccctgtc tctactaaaa atacaaaaat tggccacgtg tggtggcggg cacctgtaat   2100

cctagctact tgggaagctg agacaggaga attgcttgaa cccgggaggt ggaggttgca   2160

gtgagccaag atcatgccat tgcactccag cctgggcaac aagagcgaga ctccatcttg   2220

aaaaaaaata aaataataaa aagcagctca tactagggaa cttggtaaag caacctcatg   2280

ctgttgtagg ttgaaagcct ggtcagctat tctgcaagac agtcaaaaat tgtttacagg   2340

gctggacagc atattgctat tgaaaaatag ctattaggag accttgcaca atttgtgaaa   2400

cattgttagg ctcattgtac tgtgtaaaat caggaaagaa tttgggaaca tactgataca   2460

acaaaaagat aggttgtcaa accctcactt caccagaaag ctaaattaac cagataagtc   2520

tttctgaaag ttttagtgtc ttagtttgtt cctgcgctgt aacagaatac cttagactgg   2580

gtaacctata aataatagga atttatttct cacagttttg gaggctggca aatgcaagat   2640

ccaggtgctg gtacgttcag tgtctggcaa gggcggcttt ctggtccaag atggtgcctt   2700

tttttctgca tcttccatag ggaatgaaca ctccttatgg tagaagggat ggaaggacca   2760

ggcttttttt tttttttttt ttggatacag caggatcttg ctctgtcgcc caggctggag   2820

tgcagtggca tgattaaggt tcactgcagc ctcaatctcc cactctccag cgatcatccc   2880

acctcagcct cttggatagc tgggaccaca ggcacgagct accatgcctg gctaatttat   2940

tttttgtaga gacggggttt cgccatgttg cccaggctgg tctggaattt ctgacctcta   3000

gcagtccacc tgtttccgcc tcccaaatgc tgagattaga ggcatgagtc actgcaccca   3060

gcccgcagcc tcttttataa gggcattaat ccccttcatg agggatattc tctcatgact   3120

taatcacctg ccaaagaccc cacctcttaa tactacatca gtgatgggtt caatgtatca   3180

attgggtggg agggggcaca ttcagaccat agcatctagt cattctggtt ttattaagat   3240

ttattagacc tgaggcatga aaaatagcat actggatggg acttcagcat cgatgagttg   3300

ccttagtaat actgttaata aaaagcacta aatatgcca                          3339


<210>  8370
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  8370

Met Val Glu Gly Met Glu Gly Pro Gly Phe Phe Phe Phe Phe Phe Trp 
1               5                   10                  15      


Ile Gln Gln Asp Leu Ala Leu Ser Pro Arg Leu Glu Cys Ser Gly Met 
            20                  25                  30          


Ile Lys Val His Cys Ser Leu Asn Leu Pro Leu Ser Ser Asp His Pro 
        35                  40                  45              


Thr Ser Ala Ser Trp Ile Ala Gly Thr Thr Gly Thr Ser Tyr His Ala 
    50                  55                  60                  


Trp Leu Ile Tyr Phe Leu 
65                  70  


<210>  8371
<211>  1109
<212>  DNA
<213>  Homosapiens

<400>  8371
tggagggacg gtttgaagat gaggagctgc agcagattct tgatgatatc cagacaaagc     60

gcagctttca gtattaatct ccaaacatca ctgctgctcg gagaaaccac atccccaggc    120

ataacaccac cttcccactg tctggggctg acttgcacag aaattctgtt gaagacagtt    180

gagaattcct ttggagaaaa cagcccagct tggcgtgggg ttaggttgct gtttcaaata    240

actcacaggc ccaggtgaca tggaatcttg gagcagcctt gtgcagtggc agccagtggc    300

ttcctgaacg tgcctctgcg aagtgtgaga tgaggggtca cataaccaca ctgttgacta    360

cctcattcct ggtttttggc ctccacatca tcttttttct taatatttca tgttttaatt    420

tcagggtgtt tatacttttt gaaactagac cagaagatag tagactttat agagaaagac    480

cagttttacc tagatactaa aggaagaatt aaaccgctgt tagtttgaaa tgcttttttt    540

tttttttttt aaatggagat agggtcttaa ctcttgtcca ggctggagga tgcagtggca    600

tgattaaggt tcactgcagc ctcaatctcc cactctccag cgatcatccc acctcagcct    660

cttggatagc tgggaccaca ggcacgagct accatgcctg gctaatttat tttttgtaga    720

gacggggttt cgccatgttg cccaggctgg tctggaattt ctgacctcta gcagtccacc    780

tgtttccgcc tcccaaatgc tgagattaga ggcatgagtc actgcaccca gcccgcagcc    840

tcttttataa gggcattaat ccccttcatg agggatattc tctcatgact taatcacctg    900

ccaaagaccc cacctcttaa tactacatca gtgatgggtt caatgtatca attgggtggg    960

agggggcaca ttcagaccat agcatctagt cattctggtt ttattaagat ttattagacc   1020

tgaggcatga aaaatagcat actggatggg acttcagcat cgatgagttg ccttagtaat   1080

actgttaata aaaagcacta aatatgcca                                     1109


<210>  8372
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  8372

Met Arg Ser Cys Ser Arg Phe Leu Met Ile Ser Arg Gln Ser Ala Ala 
1               5                   10                  15      


Phe Ser Ile Asn Leu Gln Thr Ser Leu Leu Leu Gly Glu Thr Thr Ser 
            20                  25                  30          


Pro Gly Ile Thr Pro Pro Ser His Cys Leu Gly Leu Thr Cys Thr Glu 
        35                  40                  45              


Ile Leu Leu Lys Thr Val Glu Asn Ser Phe Gly Glu Asn Ser Pro Ala 
    50                  55                  60                  


Trp Arg Gly Val Arg Leu Leu Phe Gln Ile Thr His Arg Pro Arg 
65                  70                  75                  


<210>  8373
<211>  5008
<212>  DNA
<213>  Homosapiens

<400>  8373
aggcgtgagc cactgcgcct tggcaatttt tgtattttta gtagagacgg ggtttcgcca     60

tggtgctcag gctggtctcg aactcctcac gtcaagtgat tacccacctt ggcctctcag    120

agtgctggaa ttacaggtgt gagccactac acctggccgt ctagctattt ttaaatacta    180

gctacgtttg atcccttttt tcctgttgat tactctttga tttttgttgt ttatttgttt    240

ttgattattt tgattttttt tttttccttt tgattagctt gctactccag aaaaagcttc    300

ataagtttga gttggcctgt ttggccaacc tttgcccaga gactgctgag gagtccaagg    360

ctctaatccc aagcttggag ggacggtttg aagatgagga gctgcagcag attcttgatg    420

atatccagac aaagcgcagc tttcagtatt aatctccaaa catcactgct gctcggagaa    480

accacatccc caggcataac accaccttcc cactgtctgg ggctgacttg cacagaaatt    540

ctgttgaaga cagttgagaa ttcctttgga gaaaacagcc cagcttggcg tggggttagg    600

ttgctgtttc aaataactca caggcccagg tgacatggaa tcttggagca gccttgtgca    660

gtggcagcca gtggcttcct gaacgtgcct ctgcgaagtg tgagatgagg ggtcacataa    720

ccacactgtt gactacctca ttcctggttt ttggcctcca catcatcttt tttcttaata    780

tttcatgttt taatttcagg gtgtttatac tttttgaaac tagaccagaa gatagtagac    840

tttatagaga aagaccagtt ttacctagat actaaaggaa gaattaaacc gctgttagtt    900

tgaaatgctt tttttttttt tttttaaatg gagatagggt cttaactctt gtccaggctg    960

gaggagtgca gtcgtacagt catggctcac tgaagtcttg accccgctgc ctcagcctcc   1020

caaataactg gggccacagg tgtgcaccac aactctcagc taatttttaa aattttttat   1080

agaggtgggg ttttactatg ctgtccagac tggtcttaaa ctcctgggct caagtgatcc   1140

ccctgccttg gcctcccaaa ctggtgagat tacaggcatg agccaccaca actggcctga   1200

aattcttaaa ggatgggagt gtcgatgaca gcaccttggc atcgttgtgc ctaacctggg   1260

agacggaaga agcacgccat gggaagtgtt tacacttggg gacaagtgct aagtattgtg   1320

gagcccatag ccccttgaga tagatggcta ctttgccttt cttcttgaac tgtcttgcag   1380

aatgtggatt tggggtaagt ggtcttgaag gattcattta gtcaccctca aattaagatt   1440

tttacttcat ctttcttggg cctgcacctc caagataaca aagaagaagc aatggtcgtg   1500

ccaaagaggt ccacaaccag gtgtgcactg ttcactgcag cccatttgct gtatgaactg   1560

tggttgttgt gtgcccaatg acaaggctac taagaaattc atcatttgaa acgtagaggc   1620

cgcagcagtc agcgatgttt ctgaaatgag catccttgac gcctgtgtac ttcccaggct   1680

ggatgtgaag ctacattacc atgtgagttg tgccattcac agcacagtgg tgaggaattg   1740

agctcatgaa gcaggcaagg accgaacacc tccaccccaa cgtagacctg caggtgctgc   1800

cccatgacct ccaccaaagc ccatataagg agcggagttg ttaaggactg aagaaaaact   1860

tctctggaga aaaataaaat tgcaattcta cttaaaaaaa tttttttttt tttttacttc   1920

ataggccagg cttgaagttc tgaacacttt gaagtctcca attatgagag atccagtcta   1980

agcctctggc ctgctaatta gcaataagtg ctttatttgg aaggagggag tcatccactc   2040

ttgagccact gcagtgaagt cacttgatct cagtctgggg gaaaacactt caatagctaa   2100

acattctagc tttgattttt ctgaagggaa tacacttgtt ttcaattttg gggtttttct   2160

ttggggcact tgcttgactc tgtatgaact tgtgatccaa ggaaaaagga gaaagaacag   2220

tgttggcttt taaaatcagg atggttttat gtttgctacg aaataaggca agaataaaaa   2280

attcttattt ttatttattt atttattttt tgagatagag tctggctgtg ttgcccagga   2340

tgcaatggcg caatcttggc tcactgcaac ctctgccttc tgggttcaag tgattctcct   2400

gcctcagcct cccaagtagc tgggattaca ggtacctgcc accacgcctg gctaattttt   2460

tgtgttttta gtagagacag ggtttcacca cgttcgccag gctagtcttg aactgacctc   2520

aagtgatcct cccacctcgg cttcccaaag tgctgggatt acaggcgtga gccaccggcc   2580

aatcttttta tccttgagca acttcgcttc tttgagcctc attggtgttc tcaattgtga   2640

aatatggata atagtatctg ccccatgggt attttgagaa ggttgaatga acaggaaatt   2700

attacaaaga gcctagaggt gtctgatata tagtatgttc cagtaaatgt tcactattct   2760

tagcatctca ggcagatgag ctagtataga tagatgatta agtcagcttg cttcatagaa   2820

attagtgcaa gaatttgtta gcctaccaac tgatagtatc agacttggaa aataaatgaa   2880

attgggccag gcgtggtggc tcacccttgt aatcccagcg ctttcagagg ccgaggcagg   2940

cggatcacct gaggttggga gtttgagacc atcctgacca acatggagaa accccgtctc   3000

tacttaaaat acaaaattag cggggcgtgg tggcgcatgc ctgtaatctc agctactctg   3060

gaggctgagg caggagaatt gcttgaacct gggaggcaga gggggtggcg agccaagatt   3120

gcaccattgt actccagcct aggcaacaag agcgaaactg tctcaaaaaa aaaaaaaaaa   3180

aaaaagtgaa attgcttacc caaatctaca gttaactttc gttttttaat gcttgatgaa   3240

tttgcatgtc attcttgggc agtggccatg ctgtcttctc tgtattgttc caatttgggt   3300

atatgtgctg ccaaagtgag tactgcagaa ttatttcttg agagaggcac ttacatgtgc   3360

tgattggcac taaagcagtg gaatgggaag aagagacttg gaaggcagcc cagacgatcc   3420

aggcgtgtgc tagatggcaa ctgaggagca cggtgctacc atctttactg gtgtttccac   3480

ctatgtgcca ggggttctgt gagctacctg agaatactga agtatataat gctctggcac   3540

atagttaggc actaatcagt ggtatttatc aaggtgatta aaagcagatt taaaaagcag   3600

ctcacagttg ggcgcggtgg ctcacacctg taatcccagc actttgggag gccgaggcgg   3660

gtggatcacc agaggtcaga agttcgagac cagcctggcc aacgttgtga aaccctgtct   3720

ctactaaaaa tacaaaaatt ggccacgtgt ggtggcgggc acctgtaatc ctagctactt   3780

gggaagctga gacaggagaa ttgcttgaac ccgggaggtg gaggttgcag tgagccaaga   3840

tcatgccatt gcactccagc ctgggcaaca agagcgagac tccatcttga aaaaaaataa   3900

aataataaaa agcagctcat actagggaac ttggtaaagc aacctcatgc tgttgtaggt   3960

tgaaagcctg gtcagctatt ctgcaagaca gtcaaaaatt gtttacaggg ctggacagca   4020

tattgctatt gaaaaatagc tattaggaga ccttgcacaa tttgtgaaac attgttaggc   4080

tcattgtact gtgtaaaatc aggaaagaat ttgggaacat actgatacaa caaaaagata   4140

ggttgtcaaa ccctcacttc accagaaagc taaattaacc agataagtct ttctgaaagt   4200

tttagtgtct tagtttgttc ctgcgctgta acagaatacc ttagactggg taacctataa   4260

ataataggaa tttatttctc acagttttgg aggctggcaa atgcaagatc caggtgctgg   4320

tacgttcagt gtctggcaag ggcggctttc tggtccaaga tggtgccttt ttttctgcat   4380

cttccatagg gaatgaacac tccttatggt agaagggatg gaaggaccag gctttttttt   4440

tttttttttt tggatacagc aggatcttgc tctgtcgccc aggctggagt gcagtggcat   4500

gattaaggtt cactgcagcc tcaatctccc actctccagc gatcatccca cctcagcctc   4560

ttggatagct gggaccacag gcacgagcta ccatgcctgg ctaatttatt ttttgtagag   4620

acggggtttc gccatgttgc ccaggctggt ctggaatttc tgacctctag cagtccacct   4680

gtttccgcct cccaaatgct gagattagag gcatgagtca ctgcacccag cccgcagcct   4740

cttttataag ggcattaatc cccttcatga gggatattct ctcatgactt aatcacctgc   4800

caaagacccc acctcttaat actacatcag tgatgggttc aatgtatcaa ttgggtggga   4860

gggggcacat tcagaccata gcatctagtc attctggttt tattaagatt tattagacct   4920

gaggcatgaa aaatagcata ctggatggga cttcagcatc gatgagttgc cttagtaata   4980

ctgttaataa aaagcactaa atatgcca                                      5008


<210>  8374
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  8374

Met Arg Ser Cys Ser Arg Phe Leu Met Ile Ser Arg Gln Ser Ala Ala 
1               5                   10                  15      


Phe Ser Ile Asn Leu Gln Thr Ser Leu Leu Leu Gly Glu Thr Thr Ser 
            20                  25                  30          


Pro Gly Ile Thr Pro Pro Ser His Cys Leu Gly Leu Thr Cys Thr Glu 
        35                  40                  45              


Ile Leu Leu Lys Thr Val Glu Asn Ser Phe Gly Glu Asn Ser Pro Ala 
    50                  55                  60                  


Trp Arg Gly Val Arg Leu Leu Phe Gln Ile Thr His Arg Pro Arg 
65                  70                  75                  


<210>  8375
<211>  5137
<212>  DNA
<213>  Homosapiens

<400>  8375
cgcgtggtcg ccgcaggcct ggcgttatgc gcgcttcgcc caaggccctg cctcagcggc     60

ggcttgggca agccccagcg cggcgtgggg ctggggaggg aacatggcct tgggagggac    120

catggccttg ggagggaccg cctgggcaac tgggttattt tatgtgataa actgcgaagt    180

tccggggacc tgtgtcaaag ataaacaaag ccggacactc aggtgagttt gaaacagctg    240

agacacttct aaattcagaa gttcatatgc ttctggaaca tcgaaagcag cagaatgaga    300

gtgcagagga cgaacaggag ctctcagaag tcttcatgaa aacattaaac tacacagccc    360

gtttcagtcg tttcaaaaac agagagacca ttgccagtgt tcgtagcttg ctactccaga    420

aaaagcttca taagtttgag ttggcctgtt tggccaacct ttgcccagag actgctgagg    480

agtccaaggc tctaatccca agcttggagg gacggtttga agatgaggag ctgcagcaga    540

ttcttgatga tatccagaca aagcgcagct ttcagtatta atctccaaac atcactgctg    600

ctcggagaaa ccacatcccc aggcataaca ccaccttccc actgtctggg gctgacttgc    660

acagaaattc tgttgaagac agttgagaat tcctttggag aaaacagccc agcttggcgt    720

ggggttaggt tgctgtttca aataactcac aggcccaggt gacatggaat cttggagcag    780

ccttgtgcag tggcagccag tggcttcctg aacgtgcctc tgcgaagtgt gagatgaggg    840

gtcacataac cacactgttg actacctcat tcctggtttt tggcctccac atcatctttt    900

ttcttaatat ttcatgtttt aatttcaggg tgtttatact ttttgaaact agaccagaag    960

atagtagact ttatagagaa agaccagttt tacctagata ctaaaggaag aattaaaccg   1020

ctgttagttt gaaatgcttt tttttttttt ttttaaatgg agatagggtc ttaactcttg   1080

tccaggctgg aggagtgcag tcgtacagtc atggctcact gaagtcttga ccccgctgcc   1140

tcagcctccc aaataactgg ggccacaggt gtgcaccaca actctcagct aatttttaaa   1200

attttttata gaggtggggt tttactatgc tgtccagact ggtcttaaac tcctgggctc   1260

aagtgatccc cctgccttgg cctcccaaac tggtgagatt acaggcatga gccaccacaa   1320

ctggcctgaa attcttaaag gatgggagtg tcgatgacag caccttggca tcgttgtgcc   1380

taacctggga gacggaagaa gcacgccatg ggaagtgttt acacttgggg acaagtgcta   1440

agtattgtgg agcccatagc cccttgagat agatggctac tttgcctttc ttcttgaact   1500

gtcttgcaga atgtggattt ggggtaagtg gtcttgaagg attcatttag tcaccctcaa   1560

attaagattt ttacttcatc tttcttgggc ctgcacctcc aagataacaa agaagaagca   1620

atggtcgtgc caaagaggtc cacaaccagg tgtgcactgt tcactgcagc ccatttgctg   1680

tatgaactgt ggttgttgtg tgcccaatga caaggctact aagaaattca tcatttgaaa   1740

cgtagaggcc gcagcagtca gcgatgtttc tgaaatgagc atccttgacg cctgtgtact   1800

tcccaggctg gatgtgaagc tacattacca tgtgagttgt gccattcaca gcacagtggt   1860

gaggaattga gctcatgaag caggcaagga ccgaacacct ccaccccaac gtagacctgc   1920

aggtgctgcc ccatgacctc caccaaagcc catataagga gcggagttgt taaggactga   1980

agaaaaactt ctctggagaa aaataaaatt gcaattctac ttaaaaaaat tttttttttt   2040

ttttacttca taggccaggc ttgaagttct gaacactttg aagtctccaa ttatgagaga   2100

tccagtctaa gcctctggcc tgctaattag caataagtgc tttatttgga aggagggagt   2160

catccactct tgagccactg cagtgaagtc acttgatctc agtctggggg aaaacacttc   2220

aatagctaaa cattctagct ttgatttttc tgaagggaat acacttgttt tcaattttgg   2280

ggtttttctt tggggcactt gcttgactct gtatgaactt gtgatccaag gaaaaaggag   2340

aaagaacagt gttggctttt aaaatcagga tggttttatg tttgctacga aataaggcaa   2400

gaataaaaaa ttcttatttt tatttattta tttatttttt gagatagagt ctggctgtgt   2460

tgcccaggat gcaatggcgc aatcttggct cactgcaacc tctgccttct gggttcaagt   2520

gattctcctg cctcagcctc ccaagtagct gggattacag gtacctgcca ccacgcctgg   2580

ctaatttttt gtgtttttag tagagacagg gtttcaccac gttcgccagg ctagtcttga   2640

actgacctca agtgatcctc ccacctcggc ttcccaaagt gctgggatta caggcgtgag   2700

ccaccggcca atctttttat ccttgagcaa cttcgcttct ttgagcctca ttggtgttct   2760

caattgtgaa atatggataa tagtatctgc cccatgggta ttttgagaag gttgaatgaa   2820

caggaaatta ttacaaagag cctagaggtg tctgatatat agtatgttcc agtaaatgtt   2880

cactattctt agcatctcag gcagatgagc tagtatagat agatgattaa gtcagcttgc   2940

ttcatagaaa ttagtgcaag aatttgttag cctaccaact gatagtatca gacttggaaa   3000

ataaatgaaa ttgggccagg cgtggtggct cacccttgta atcccagcgc tttcagaggc   3060

cgaggcaggc ggatcacctg aggttgggag tttgagacca tcctgaccaa catggagaaa   3120

ccccgtctct acttaaaata caaaattagc ggggcgtggt ggcgcatgcc tgtaatctca   3180

gctactctgg aggctgaggc aggagaattg cttgaacctg ggaggcagag ggggtggcga   3240

gccaagattg caccattgta ctccagccta ggcaacaaga gcgaaactgt ctcaaaaaaa   3300

aaaaaaaaaa aaaagtgaaa ttgcttaccc aaatctacag ttaactttcg ttttttaatg   3360

cttgatgaat ttgcatgtca ttcttgggca gtggccatgc tgtcttctct gtattgttcc   3420

aatttgggta tatgtgctgc caaagtgagt actgcagaat tatttcttga gagaggcact   3480

tacatgtgct gattggcact aaagcagtgg aatgggaaga agagacttgg aaggcagccc   3540

agacgatcca ggcgtgtgct agatggcaac tgaggagcac ggtgctacca tctttactgg   3600

tgtttccacc tatgtgccag gggttctgtg agctacctga gaatactgaa gtatataatg   3660

ctctggcaca tagttaggca ctaatcagtg gtatttatca aggtgattaa aagcagattt   3720

aaaaagcagc tcacagttgg gcgcggtggc tcacacctgt aatcccagca ctttgggagg   3780

ccgaggcggg tggatcacca gaggtcagaa gttcgagacc agcctggcca acgttgtgaa   3840

accctgtctc tactaaaaat acaaaaattg gccacgtgtg gtggcgggca cctgtaatcc   3900

tagctacttg ggaagctgag acaggagaat tgcttgaacc cgggaggtgg aggttgcagt   3960

gagccaagat catgccattg cactccagcc tgggcaacaa gagcgagact ccatcttgaa   4020

aaaaaataaa ataataaaaa gcagctcata ctagggaact tggtaaagca acctcatgct   4080

gttgtaggtt gaaagcctgg tcagctattc tgcaagacag tcaaaaattg tttacagggc   4140

tggacagcat attgctattg aaaaatagct attaggagac cttgcacaat ttgtgaaaca   4200

ttgttaggct cattgtactg tgtaaaatca ggaaagaatt tgggaacata ctgatacaac   4260

aaaaagatag gttgtcaaac cctcacttca ccagaaagct aaattaacca gataagtctt   4320

tctgaaagtt ttagtgtctt agtttgttcc tgcgctgtaa cagaatacct tagactgggt   4380

aacctataaa taataggaat ttatttctca cagttttgga ggctggcaaa tgcaagatcc   4440

aggtgctggt acgttcagtg tctggcaagg gcggctttct ggtccaagat ggtgcctttt   4500

tttctgcatc ttccataggg aatgaacact ccttatggta gaagggatgg aaggaccagg   4560

cttttttttt tttttttttt ggatacagca ggatcttgct ctgtcgccca ggctggagtg   4620

cagtggcatg attaaggttc actgcagcct caatctccca ctctccagcg atcatcccac   4680

ctcagcctct tggatagctg ggaccacagg cacgagctac catgcctggc taatttattt   4740

tttgtagaga cggggtttcg ccatgttgcc caggctggtc tggaatttct gacctctagc   4800

agtccacctg tttccgcctc ccaaatgctg agattagagg catgagtcac tgcacccagc   4860

ccgcagcctc ttttataagg gcattaatcc ccttcatgag ggatattctc tcatgactta   4920

atcacctgcc aaagacccca cctcttaata ctacatcagt gatgggttca atgtatcaat   4980

tgggtgggag ggggcacatt cagaccatag catctagtca ttctggtttt attaagattt   5040

attagacctg aggcatgaaa aatagcatac tggatgggac ttcagcatcg atgagttgcc   5100

ttagtaatac tgttaataaa aagcactaaa tatgcca                            5137


<210>  8376
<211>  104
<212>  PRT
<213>  Homosapiens

<400>  8376

Met Leu Leu Glu His Arg Lys Gln Gln Asn Glu Ser Ala Glu Asp Glu 
1               5                   10                  15      


Gln Glu Leu Ser Glu Val Phe Met Lys Thr Leu Asn Tyr Thr Ala Arg 
            20                  25                  30          


Phe Ser Arg Phe Lys Asn Arg Glu Thr Ile Ala Ser Val Arg Ser Leu 
        35                  40                  45              


Leu Leu Gln Lys Lys Leu His Lys Phe Glu Leu Ala Cys Leu Ala Asn 
    50                  55                  60                  


Leu Cys Pro Glu Thr Ala Glu Glu Ser Lys Ala Leu Ile Pro Ser Leu 
65                  70                  75                  80  


Glu Gly Arg Phe Glu Asp Glu Glu Leu Gln Gln Ile Leu Asp Asp Ile 
                85                  90                  95      


Gln Thr Lys Arg Ser Phe Gln Tyr 
            100                 


<210>  8377
<211>  4727
<212>  DNA
<213>  Homosapiens

<400>  8377
cgcgcggcgc ggcgcggcga tggcggcggg tggcagcgat ccgcgggctg gcgacgtaga     60

ggaggacgcc tcacagctca tctttcctaa agcttggagg gacggtttga agatgaggag    120

ctgcagcaga ttcttgatga tatccagaca aagcgcagct ttcagtatta atctccaaac    180

atcactgctg ctcggagaaa ccacatcccc aggcataaca ccaccttccc actgtctggg    240

gctgacttgc acagaaattc tgttgaagac agttgagaat tcctttggag aaaacagccc    300

agcttggcgt ggggttaggt tgctgtttca aataactcac aggcccaggt gacatggaat    360

cttggagcag ccttgtgcag tggcagccag tggcttcctg aacgtgcctc tgcgaagtgt    420

gagatgaggg gtcacataac cacactgttg actacctcat tcctggtttt tggcctccac    480

atcatctttt ttcttaatat ttcatgtttt aatttcaggg tgtttatact ttttgaaact    540

agaccagaag atagtagact ttatagagaa agaccagttt tacctagata ctaaaggaag    600

aattaaaccg ctgttagttt gaaatgcttt tttttttttt ttttaaatgg agatagggtc    660

ttaactcttg tccaggctgg aggagtgcag tcgtacagtc atggctcact gaagtcttga    720

ccccgctgcc tcagcctccc aaataactgg ggccacaggt gtgcaccaca actctcagct    780

aatttttaaa attttttata gaggtggggt tttactatgc tgtccagact ggtcttaaac    840

tcctgggctc aagtgatccc cctgccttgg cctcccaaac tggtgagatt acaggcatga    900

gccaccacaa ctggcctgaa attcttaaag gatgggagtg tcgatgacag caccttggca    960

tcgttgtgcc taacctggga gacggaagaa gcacgccatg ggaagtgttt acacttgggg   1020

acaagtgcta agtattgtgg agcccatagc cccttgagat agatggctac tttgcctttc   1080

ttcttgaact gtcttgcaga atgtggattt ggggtaagtg gtcttgaagg attcatttag   1140

tcaccctcaa attaagattt ttacttcatc tttcttgggc ctgcacctcc aagataacaa   1200

agaagaagca atggtcgtgc caaagaggtc cacaaccagg tgtgcactgt tcactgcagc   1260

ccatttgctg tatgaactgt ggttgttgtg tgcccaatga caaggctact aagaaattca   1320

tcatttgaaa cgtagaggcc gcagcagtca gcgatgtttc tgaaatgagc atccttgacg   1380

cctgtgtact tcccaggctg gatgtgaagc tacattacca tgtgagttgt gccattcaca   1440

gcacagtggt gaggaattga gctcatgaag caggcaagga ccgaacacct ccaccccaac   1500

gtagacctgc aggtgctgcc ccatgacctc caccaaagcc catataagga gcggagttgt   1560

taaggactga agaaaaactt ctctggagaa aaataaaatt gcaattctac ttaaaaaaat   1620

tttttttttt ttttacttca taggccaggc ttgaagttct gaacactttg aagtctccaa   1680

ttatgagaga tccagtctaa gcctctggcc tgctaattag caataagtgc tttatttgga   1740

aggagggagt catccactct tgagccactg cagtgaagtc acttgatctc agtctggggg   1800

aaaacacttc aatagctaaa cattctagct ttgatttttc tgaagggaat acacttgttt   1860

tcaattttgg ggtttttctt tggggcactt gcttgactct gtatgaactt gtgatccaag   1920

gaaaaaggag aaagaacagt gttggctttt aaaatcagga tggttttatg tttgctacga   1980

aataaggcaa gaataaaaaa ttcttatttt tatttattta tttatttttt gagatagagt   2040

ctggctgtgt tgcccaggat gcaatggcgc aatcttggct cactgcaacc tctgccttct   2100

gggttcaagt gattctcctg cctcagcctc ccaagtagct gggattacag gtacctgcca   2160

ccacgcctgg ctaatttttt gtgtttttag tagagacagg gtttcaccac gttcgccagg   2220

ctagtcttga actgacctca agtgatcctc ccacctcggc ttcccaaagt gctgggatta   2280

caggcgtgag ccaccggcca atctttttat ccttgagcaa cttcgcttct ttgagcctca   2340

ttggtgttct caattgtgaa atatggataa tagtatctgc cccatgggta ttttgagaag   2400

gttgaatgaa caggaaatta ttacaaagag cctagaggtg tctgatatat agtatgttcc   2460

agtaaatgtt cactattctt agcatctcag gcagatgagc tagtatagat agatgattaa   2520

gtcagcttgc ttcatagaaa ttagtgcaag aatttgttag cctaccaact gatagtatca   2580

gacttggaaa ataaatgaaa ttgggccagg cgtggtggct cacccttgta atcccagcgc   2640

tttcagaggc cgaggcaggc ggatcacctg aggttgggag tttgagacca tcctgaccaa   2700

catggagaaa ccccgtctct acttaaaata caaaattagc ggggcgtggt ggcgcatgcc   2760

tgtaatctca gctactctgg aggctgaggc aggagaattg cttgaacctg ggaggcagag   2820

ggggtggcga gccaagattg caccattgta ctccagccta ggcaacaaga gcgaaactgt   2880

ctcaaaaaaa aaaaaaaaaa aaaagtgaaa ttgcttaccc aaatctacag ttaactttcg   2940

ttttttaatg cttgatgaat ttgcatgtca ttcttgggca gtggccatgc tgtcttctct   3000

gtattgttcc aatttgggta tatgtgctgc caaagtgagt actgcagaat tatttcttga   3060

gagaggcact tacatgtgct gattggcact aaagcagtgg aatgggaaga agagacttgg   3120

aaggcagccc agacgatcca ggcgtgtgct agatggcaac tgaggagcac ggtgctacca   3180

tctttactgg tgtttccacc tatgtgccag gggttctgtg agctacctga gaatactgaa   3240

gtatataatg ctctggcaca tagttaggca ctaatcagtg gtatttatca aggtgattaa   3300

aagcagattt aaaaagcagc tcacagttgg gcgcggtggc tcacacctgt aatcccagca   3360

ctttgggagg ccgaggcggg tggatcacca gaggtcagaa gttcgagacc agcctggcca   3420

acgttgtgaa accctgtctc tactaaaaat acaaaaattg gccacgtgtg gtggcgggca   3480

cctgtaatcc tagctacttg ggaagctgag acaggagaat tgcttgaacc cgggaggtgg   3540

aggttgcagt gagccaagat catgccattg cactccagcc tgggcaacaa gagcgagact   3600

ccatcttgaa aaaaaataaa ataataaaaa gcagctcata ctagggaact tggtaaagca   3660

acctcatgct gttgtaggtt gaaagcctgg tcagctattc tgcaagacag tcaaaaattg   3720

tttacagggc tggacagcat attgctattg aaaaatagct attaggagac cttgcacaat   3780

ttgtgaaaca ttgttaggct cattgtactg tgtaaaatca ggaaagaatt tgggaacata   3840

ctgatacaac aaaaagatag gttgtcaaac cctcacttca ccagaaagct aaattaacca   3900

gataagtctt tctgaaagtt ttagtgtctt agtttgttcc tgcgctgtaa cagaatacct   3960

tagactgggt aacctataaa taataggaat ttatttctca cagttttgga ggctggcaaa   4020

tgcaagatcc aggtgctggt acgttcagtg tctggcaagg gcggctttct ggtccaagat   4080

ggtgcctttt tttctgcatc ttccataggg aatgaacact ccttatggta gaagggatgg   4140

aaggaccagg cttttttttt tttttttttt ggatacagca ggatcttgct ctgtcgccca   4200

ggctggagtg cagtggcatg attaaggttc actgcagcct caatctccca ctctccagcg   4260

atcatcccac ctcagcctct tggatagctg ggaccacagg cacgagctac catgcctggc   4320

taatttattt tttgtagaga cggggtttcg ccatgttgcc caggctggtc tggaatttct   4380

gacctctagc agtccacctg tttccgcctc ccaaatgctg agattagagg catgagtcac   4440

tgcacccagc ccgcagcctc ttttataagg gcattaatcc ccttcatgag ggatattctc   4500

tcatgactta atcacctgcc aaagacccca cctcttaata ctacatcagt gatgggttca   4560

atgtatcaat tgggtgggag ggggcacatt cagaccatag catctagtca ttctggtttt   4620

attaagattt attagacctg aggcatgaaa aatagcatac tggatgggac ttcagcatcg   4680

atgagttgcc ttagtaatac tgttaataaa aagcactaaa tatgcca                 4727


<210>  8378
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  8378

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Ala Trp Arg Asp Gly Leu Lys Met 
            20                  25                  30          


Arg Ser Cys Ser Arg Phe Leu Met Ile Ser Arg Gln Ser Ala Ala Phe 
        35                  40                  45              


Ser Ile Asn Leu Gln Thr Ser Leu Leu Leu Gly Glu Thr Thr Ser Pro 
    50                  55                  60                  


Gly Ile Thr Pro Pro Ser His Cys Leu Gly Leu Thr Cys Thr Glu Ile 
65                  70                  75                  80  


Leu Leu Lys Thr Val Glu Asn Ser Phe Gly Glu Asn Ser Pro Ala Trp 
                85                  90                  95      


Arg Gly Val Arg Leu Leu Phe Gln Ile Thr His Arg Pro Arg 
            100                 105                 110 


<210>  8379
<211>  4825
<212>  DNA
<213>  Homosapiens

<400>  8379
ggcgcgcggc gcggcgcggc gatggcggcg ggtggcagcg atccgcgggc tggcgacgta     60

gaggaggacg cctcacagct catctttcct aaagcttgct actccagaaa aagcttcata    120

agtttgagtt ggcctgtttg gccaaccttt gcccagagac tgctgaggag tccaaggctc    180

taatcccaag cttggaggga cggtttgaag atgaggagct gcagcagatt cttgatgata    240

tccagacaaa gcgcagcttt cagtattaat ctccaaacat cactgctgct cggagaaacc    300

acatccccag gcataacacc accttcccac tgtctggggc tgacttgcac agaaattctg    360

ttgaagacag ttgagaattc ctttggagaa aacagcccag cttggcgtgg ggttaggttg    420

ctgtttcaaa taactcacag gcccaggtga catggaatct tggagcagcc ttgtgcagtg    480

gcagccagtg gcttcctgaa cgtgcctctg cgaagtgtga gatgaggggt cacataacca    540

cactgttgac tacctcattc ctggtttttg gcctccacat catctttttt cttaatattt    600

catgttttaa tttcagggtg tttatacttt ttgaaactag accagaagat agtagacttt    660

atagagaaag accagtttta cctagatact aaaggaagaa ttaaaccgct gttagtttga    720

aatgcttttt tttttttttt ttaaatggag atagggtctt aactcttgtc caggctggag    780

gagtgcagtc gtacagtcat ggctcactga agtcttgacc ccgctgcctc agcctcccaa    840

ataactgggg ccacaggtgt gcaccacaac tctcagctaa tttttaaaat tttttataga    900

ggtggggttt tactatgctg tccagactgg tcttaaactc ctgggctcaa gtgatccccc    960

tgccttggcc tcccaaactg gtgagattac aggcatgagc caccacaact ggcctgaaat   1020

tcttaaagga tgggagtgtc gatgacagca ccttggcatc gttgtgccta acctgggaga   1080

cggaagaagc acgccatggg aagtgtttac acttggggac aagtgctaag tattgtggag   1140

cccatagccc cttgagatag atggctactt tgcctttctt cttgaactgt cttgcagaat   1200

gtggatttgg ggtaagtggt cttgaaggat tcatttagtc accctcaaat taagattttt   1260

acttcatctt tcttgggcct gcacctccaa gataacaaag aagaagcaat ggtcgtgcca   1320

aagaggtcca caaccaggtg tgcactgttc actgcagccc atttgctgta tgaactgtgg   1380

ttgttgtgtg cccaatgaca aggctactaa gaaattcatc atttgaaacg tagaggccgc   1440

agcagtcagc gatgtttctg aaatgagcat ccttgacgcc tgtgtacttc ccaggctgga   1500

tgtgaagcta cattaccatg tgagttgtgc cattcacagc acagtggtga ggaattgagc   1560

tcatgaagca ggcaaggacc gaacacctcc accccaacgt agacctgcag gtgctgcccc   1620

atgacctcca ccaaagccca tataaggagc ggagttgtta aggactgaag aaaaacttct   1680

ctggagaaaa ataaaattgc aattctactt aaaaaaattt tttttttttt ttacttcata   1740

ggccaggctt gaagttctga acactttgaa gtctccaatt atgagagatc cagtctaagc   1800

ctctggcctg ctaattagca ataagtgctt tatttggaag gagggagtca tccactcttg   1860

agccactgca gtgaagtcac ttgatctcag tctgggggaa aacacttcaa tagctaaaca   1920

ttctagcttt gatttttctg aagggaatac acttgttttc aattttgggg tttttctttg   1980

gggcacttgc ttgactctgt atgaacttgt gatccaagga aaaaggagaa agaacagtgt   2040

tggcttttaa aatcaggatg gttttatgtt tgctacgaaa taaggcaaga ataaaaaatt   2100

cttattttta tttatttatt tattttttga gatagagtct ggctgtgttg cccaggatgc   2160

aatggcgcaa tcttggctca ctgcaacctc tgccttctgg gttcaagtga ttctcctgcc   2220

tcagcctccc aagtagctgg gattacaggt acctgccacc acgcctggct aattttttgt   2280

gtttttagta gagacagggt ttcaccacgt tcgccaggct agtcttgaac tgacctcaag   2340

tgatcctccc acctcggctt cccaaagtgc tgggattaca ggcgtgagcc accggccaat   2400

ctttttatcc ttgagcaact tcgcttcttt gagcctcatt ggtgttctca attgtgaaat   2460

atggataata gtatctgccc catgggtatt ttgagaaggt tgaatgaaca ggaaattatt   2520

acaaagagcc tagaggtgtc tgatatatag tatgttccag taaatgttca ctattcttag   2580

catctcaggc agatgagcta gtatagatag atgattaagt cagcttgctt catagaaatt   2640

agtgcaagaa tttgttagcc taccaactga tagtatcaga cttggaaaat aaatgaaatt   2700

gggccaggcg tggtggctca cccttgtaat cccagcgctt tcagaggccg aggcaggcgg   2760

atcacctgag gttgggagtt tgagaccatc ctgaccaaca tggagaaacc ccgtctctac   2820

ttaaaataca aaattagcgg ggcgtggtgg cgcatgcctg taatctcagc tactctggag   2880

gctgaggcag gagaattgct tgaacctggg aggcagaggg ggtggcgagc caagattgca   2940

ccattgtact ccagcctagg caacaagagc gaaactgtct caaaaaaaaa aaaaaaaaaa   3000

aagtgaaatt gcttacccaa atctacagtt aactttcgtt ttttaatgct tgatgaattt   3060

gcatgtcatt cttgggcagt ggccatgctg tcttctctgt attgttccaa tttgggtata   3120

tgtgctgcca aagtgagtac tgcagaatta tttcttgaga gaggcactta catgtgctga   3180

ttggcactaa agcagtggaa tgggaagaag agacttggaa ggcagcccag acgatccagg   3240

cgtgtgctag atggcaactg aggagcacgg tgctaccatc tttactggtg tttccaccta   3300

tgtgccaggg gttctgtgag ctacctgaga atactgaagt atataatgct ctggcacata   3360

gttaggcact aatcagtggt atttatcaag gtgattaaaa gcagatttaa aaagcagctc   3420

acagttgggc gcggtggctc acacctgtaa tcccagcact ttgggaggcc gaggcgggtg   3480

gatcaccaga ggtcagaagt tcgagaccag cctggccaac gttgtgaaac cctgtctcta   3540

ctaaaaatac aaaaattggc cacgtgtggt ggcgggcacc tgtaatccta gctacttggg   3600

aagctgagac aggagaattg cttgaacccg ggaggtggag gttgcagtga gccaagatca   3660

tgccattgca ctccagcctg ggcaacaaga gcgagactcc atcttgaaaa aaaataaaat   3720

aataaaaagc agctcatact agggaacttg gtaaagcaac ctcatgctgt tgtaggttga   3780

aagcctggtc agctattctg caagacagtc aaaaattgtt tacagggctg gacagcatat   3840

tgctattgaa aaatagctat taggagacct tgcacaattt gtgaaacatt gttaggctca   3900

ttgtactgtg taaaatcagg aaagaatttg ggaacatact gatacaacaa aaagataggt   3960

tgtcaaaccc tcacttcacc agaaagctaa attaaccaga taagtctttc tgaaagtttt   4020

agtgtcttag tttgttcctg cgctgtaaca gaatacctta gactgggtaa cctataaata   4080

ataggaattt atttctcaca gttttggagg ctggcaaatg caagatccag gtgctggtac   4140

gttcagtgtc tggcaagggc ggctttctgg tccaagatgg tgcctttttt tctgcatctt   4200

ccatagggaa tgaacactcc ttatggtaga agggatggaa ggaccaggct tttttttttt   4260

ttttttttgg atacagcagg atcttgctct gtcgcccagg ctggagtgca gtggcatgat   4320

taaggttcac tgcagcctca atctcccact ctccagcgat catcccacct cagcctcttg   4380

gatagctggg accacaggca cgagctacca tgcctggcta atttattttt tgtagagacg   4440

gggtttcgcc atgttgccca ggctggtctg gaatttctga cctctagcag tccacctgtt   4500

tccgcctccc aaatgctgag attagaggca tgagtcactg cacccagccc gcagcctctt   4560

ttataagggc attaatcccc ttcatgaggg atattctctc atgacttaat cacctgccaa   4620

agaccccacc tcttaatact acatcagtga tgggttcaat gtatcaattg ggtgggaggg   4680

ggcacattca gaccatagca tctagtcatt ctggttttat taagatttat tagacctgag   4740

gcatgaaaaa tagcatactg gatgggactt cagcatcgat gagttgcctt agtaatactg   4800

ttaataaaaa gcactaaata tgcca                                         4825


<210>  8380
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  8380

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Ala Cys Tyr Ser Arg Lys Ser Phe 
            20                  25                  30          


Ile Ser Leu Ser Trp Pro Val Trp Pro Thr Phe Ala Gln Arg Leu Leu 
        35                  40                  45              


Arg Ser Pro Arg Leu 
    50              


<210>  8381
<211>  4916
<212>  DNA
<213>  Homosapiens

<400>  8381
ggtggtggcg cgcggcgcgg cgcggcgatg gcggcgggtg gcagcgatcc gcgggctggc     60

gacgtagagg aggacgcctc acagctcatc tttcctaaag agtttgaaac agctgagaca    120

cttctaaatt cagaagttca tatgcttctg gaacatcgaa agcagcagaa tgagagtgca    180

gaggacgaac aggagctctc agaagtcttc atgaaaacat taaactacac agcccgtttc    240

agtcgtttca aaaacagaga gaccattgcc agtgttcgta gcttggaggg acggtttgaa    300

gatgaggagc tgcagcagat tcttgatgat atccagacaa agcgcagctt tcagtattaa    360

tctccaaaca tcactgctgc tcggagaaac cacatcccca ggcataacac caccttccca    420

ctgtctgggg ctgacttgca cagaaattct gttgaagaca gttgagaatt cctttggaga    480

aaacagccca gcttggcgtg gggttaggtt gctgtttcaa ataactcaca ggcccaggtg    540

acatggaatc ttggagcagc cttgtgcagt ggcagccagt ggcttcctga acgtgcctct    600

gcgaagtgtg agatgagggg tcacataacc acactgttga ctacctcatt cctggttttt    660

ggcctccaca tcatcttttt tcttaatatt tcatgtttta atttcagggt gtttatactt    720

tttgaaacta gaccagaaga tagtagactt tatagagaaa gaccagtttt acctagatac    780

taaaggaaga attaaaccgc tgttagtttg aaatgctttt tttttttttt tttaaatgga    840

gatagggtct taactcttgt ccaggctgga ggagtgcagt cgtacagtca tggctcactg    900

aagtcttgac cccgctgcct cagcctccca aataactggg gccacaggtg tgcaccacaa    960

ctctcagcta atttttaaaa ttttttatag aggtggggtt ttactatgct gtccagactg   1020

gtcttaaact cctgggctca agtgatcccc ctgccttggc ctcccaaact ggtgagatta   1080

caggcatgag ccaccacaac tggcctgaaa ttcttaaagg atgggagtgt cgatgacagc   1140

accttggcat cgttgtgcct aacctgggag acggaagaag cacgccatgg gaagtgttta   1200

cacttgggga caagtgctaa gtattgtgga gcccatagcc ccttgagata gatggctact   1260

ttgcctttct tcttgaactg tcttgcagaa tgtggatttg gggtaagtgg tcttgaagga   1320

ttcatttagt caccctcaaa ttaagatttt tacttcatct ttcttgggcc tgcacctcca   1380

agataacaaa gaagaagcaa tggtcgtgcc aaagaggtcc acaaccaggt gtgcactgtt   1440

cactgcagcc catttgctgt atgaactgtg gttgttgtgt gcccaatgac aaggctacta   1500

agaaattcat catttgaaac gtagaggccg cagcagtcag cgatgtttct gaaatgagca   1560

tccttgacgc ctgtgtactt cccaggctgg atgtgaagct acattaccat gtgagttgtg   1620

ccattcacag cacagtggtg aggaattgag ctcatgaagc aggcaaggac cgaacacctc   1680

caccccaacg tagacctgca ggtgctgccc catgacctcc accaaagccc atataaggag   1740

cggagttgtt aaggactgaa gaaaaacttc tctggagaaa aataaaattg caattctact   1800

taaaaaaatt tttttttttt tttacttcat aggccaggct tgaagttctg aacactttga   1860

agtctccaat tatgagagat ccagtctaag cctctggcct gctaattagc aataagtgct   1920

ttatttggaa ggagggagtc atccactctt gagccactgc agtgaagtca cttgatctca   1980

gtctggggga aaacacttca atagctaaac attctagctt tgatttttct gaagggaata   2040

cacttgtttt caattttggg gtttttcttt ggggcacttg cttgactctg tatgaacttg   2100

tgatccaagg aaaaaggaga aagaacagtg ttggctttta aaatcaggat ggttttatgt   2160

ttgctacgaa ataaggcaag aataaaaaat tcttattttt atttatttat ttattttttg   2220

agatagagtc tggctgtgtt gcccaggatg caatggcgca atcttggctc actgcaacct   2280

ctgccttctg ggttcaagtg attctcctgc ctcagcctcc caagtagctg ggattacagg   2340

tacctgccac cacgcctggc taattttttg tgtttttagt agagacaggg tttcaccacg   2400

ttcgccaggc tagtcttgaa ctgacctcaa gtgatcctcc cacctcggct tcccaaagtg   2460

ctgggattac aggcgtgagc caccggccaa tctttttatc cttgagcaac ttcgcttctt   2520

tgagcctcat tggtgttctc aattgtgaaa tatggataat agtatctgcc ccatgggtat   2580

tttgagaagg ttgaatgaac aggaaattat tacaaagagc ctagaggtgt ctgatatata   2640

gtatgttcca gtaaatgttc actattctta gcatctcagg cagatgagct agtatagata   2700

gatgattaag tcagcttgct tcatagaaat tagtgcaaga atttgttagc ctaccaactg   2760

atagtatcag acttggaaaa taaatgaaat tgggccaggc gtggtggctc acccttgtaa   2820

tcccagcgct ttcagaggcc gaggcaggcg gatcacctga ggttgggagt ttgagaccat   2880

cctgaccaac atggagaaac cccgtctcta cttaaaatac aaaattagcg gggcgtggtg   2940

gcgcatgcct gtaatctcag ctactctgga ggctgaggca ggagaattgc ttgaacctgg   3000

gaggcagagg gggtggcgag ccaagattgc accattgtac tccagcctag gcaacaagag   3060

cgaaactgtc tcaaaaaaaa aaaaaaaaaa aaagtgaaat tgcttaccca aatctacagt   3120

taactttcgt tttttaatgc ttgatgaatt tgcatgtcat tcttgggcag tggccatgct   3180

gtcttctctg tattgttcca atttgggtat atgtgctgcc aaagtgagta ctgcagaatt   3240

atttcttgag agaggcactt acatgtgctg attggcacta aagcagtgga atgggaagaa   3300

gagacttgga aggcagccca gacgatccag gcgtgtgcta gatggcaact gaggagcacg   3360

gtgctaccat ctttactggt gtttccacct atgtgccagg ggttctgtga gctacctgag   3420

aatactgaag tatataatgc tctggcacat agttaggcac taatcagtgg tatttatcaa   3480

ggtgattaaa agcagattta aaaagcagct cacagttggg cgcggtggct cacacctgta   3540

atcccagcac tttgggaggc cgaggcgggt ggatcaccag aggtcagaag ttcgagacca   3600

gcctggccaa cgttgtgaaa ccctgtctct actaaaaata caaaaattgg ccacgtgtgg   3660

tggcgggcac ctgtaatcct agctacttgg gaagctgaga caggagaatt gcttgaaccc   3720

gggaggtgga ggttgcagtg agccaagatc atgccattgc actccagcct gggcaacaag   3780

agcgagactc catcttgaaa aaaaataaaa taataaaaag cagctcatac tagggaactt   3840

ggtaaagcaa cctcatgctg ttgtaggttg aaagcctggt cagctattct gcaagacagt   3900

caaaaattgt ttacagggct ggacagcata ttgctattga aaaatagcta ttaggagacc   3960

ttgcacaatt tgtgaaacat tgttaggctc attgtactgt gtaaaatcag gaaagaattt   4020

gggaacatac tgatacaaca aaaagatagg ttgtcaaacc ctcacttcac cagaaagcta   4080

aattaaccag ataagtcttt ctgaaagttt tagtgtctta gtttgttcct gcgctgtaac   4140

agaatacctt agactgggta acctataaat aataggaatt tatttctcac agttttggag   4200

gctggcaaat gcaagatcca ggtgctggta cgttcagtgt ctggcaaggg cggctttctg   4260

gtccaagatg gtgccttttt ttctgcatct tccataggga atgaacactc cttatggtag   4320

aagggatgga aggaccaggc tttttttttt tttttttttg gatacagcag gatcttgctc   4380

tgtcgcccag gctggagtgc agtggcatga ttaaggttca ctgcagcctc aatctcccac   4440

tctccagcga tcatcccacc tcagcctctt ggatagctgg gaccacaggc acgagctacc   4500

atgcctggct aatttatttt ttgtagagac ggggtttcgc catgttgccc aggctggtct   4560

ggaatttctg acctctagca gtccacctgt ttccgcctcc caaatgctga gattagaggc   4620

atgagtcact gcacccagcc cgcagcctct tttataaggg cattaatccc cttcatgagg   4680

gatattctct catgacttaa tcacctgcca aagaccccac ctcttaatac tacatcagtg   4740

atgggttcaa tgtatcaatt gggtgggagg gggcacattc agaccatagc atctagtcat   4800

tctggtttta ttaagattta ttagacctga ggcatgaaaa atagcatact ggatgggact   4860

tcagcatcga tgagttgcct tagtaatact gttaataaaa agcactaaat atgcca       4916


<210>  8382
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  8382

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Glu Phe Glu Thr Ala Glu Thr Leu 
            20                  25                  30          


Leu Asn Ser Glu Val His Met Leu Leu Glu His Arg Lys Gln Gln Asn 
        35                  40                  45              


Glu Ser Ala Glu Asp Glu Gln Glu Leu Ser Glu Val Phe Met Lys Thr 
    50                  55                  60                  


Leu Asn Tyr Thr Ala Arg Phe Ser Arg Phe Lys Asn Arg Glu Thr Ile 
65                  70                  75                  80  


Ala Ser Val Arg Ser Leu Glu Gly Arg Phe Glu Asp Glu Glu Leu Gln 
                85                  90                  95      


Gln Ile Leu Asp Asp Ile Gln Thr Lys Arg Ser Phe Gln Tyr 
            100                 105                 110 


<210>  8383
<211>  5033
<212>  DNA
<213>  Homosapiens

<400>  8383
gcttctgctt ccggcggcgc tggtggtggc gcgcggcgcg gcgcggcgat ggcggcgggt     60

ggcagcgatc cgcgggctgg cgacgtagag gaggacgcct cacagctcat ctttcctaaa    120

gagtttgaaa cagctgagac acttctaaat tcagaagttc atatgcttct ggaacatcga    180

aagcagcaga atgagagtgc agaggacgaa caggagctct cagaagtctt catgaaaaca    240

ttaaactaca cagcccgttt cagtcgtttc aaaaacagag agaccattgc cagtgttcgt    300

agcttgctac tccagaaaaa gcttcataag tttgagttgg cctgtttggc caacctttgc    360

ccagagactg ctgaggagtc caaggctcta atcccaagct tggagggacg gtttgaagat    420

gaggagctgc agcagattct tgatgatatc cagacaaagc gcagctttca gtattaatct    480

ccaaacatca ctgctgctcg gagaaaccac atccccaggc ataacaccac cttcccactg    540

tctggggctg acttgcacag aaattctgtt gaagacagtt gagaattcct ttggagaaaa    600

cagcccagct tggcgtgggg ttaggttgct gtttcaaata actcacaggc ccaggtgaca    660

tggaatcttg gagcagcctt gtgcagtggc agccagtggc ttcctgaacg tgcctctgcg    720

aagtgtgaga tgaggggtca cataaccaca ctgttgacta cctcattcct ggtttttggc    780

ctccacatca tcttttttct taatatttca tgttttaatt tcagggtgtt tatacttttt    840

gaaactagac cagaagatag tagactttat agagaaagac cagttttacc tagatactaa    900

aggaagaatt aaaccgctgt tagtttgaaa tgcttttttt tttttttttt aaatggagat    960

agggtcttaa ctcttgtcca ggctggagga gtgcagtcgt acagtcatgg ctcactgaag   1020

tcttgacccc gctgcctcag cctcccaaat aactggggcc acaggtgtgc accacaactc   1080

tcagctaatt tttaaaattt tttatagagg tggggtttta ctatgctgtc cagactggtc   1140

ttaaactcct gggctcaagt gatccccctg ccttggcctc ccaaactggt gagattacag   1200

gcatgagcca ccacaactgg cctgaaattc ttaaaggatg ggagtgtcga tgacagcacc   1260

ttggcatcgt tgtgcctaac ctgggagacg gaagaagcac gccatgggaa gtgtttacac   1320

ttggggacaa gtgctaagta ttgtggagcc catagcccct tgagatagat ggctactttg   1380

cctttcttct tgaactgtct tgcagaatgt ggatttgggg taagtggtct tgaaggattc   1440

atttagtcac cctcaaatta agatttttac ttcatctttc ttgggcctgc acctccaaga   1500

taacaaagaa gaagcaatgg tcgtgccaaa gaggtccaca accaggtgtg cactgttcac   1560

tgcagcccat ttgctgtatg aactgtggtt gttgtgtgcc caatgacaag gctactaaga   1620

aattcatcat ttgaaacgta gaggccgcag cagtcagcga tgtttctgaa atgagcatcc   1680

ttgacgcctg tgtacttccc aggctggatg tgaagctaca ttaccatgtg agttgtgcca   1740

ttcacagcac agtggtgagg aattgagctc atgaagcagg caaggaccga acacctccac   1800

cccaacgtag acctgcaggt gctgccccat gacctccacc aaagcccata taaggagcgg   1860

agttgttaag gactgaagaa aaacttctct ggagaaaaat aaaattgcaa ttctacttaa   1920

aaaaattttt tttttttttt acttcatagg ccaggcttga agttctgaac actttgaagt   1980

ctccaattat gagagatcca gtctaagcct ctggcctgct aattagcaat aagtgcttta   2040

tttggaagga gggagtcatc cactcttgag ccactgcagt gaagtcactt gatctcagtc   2100

tgggggaaaa cacttcaata gctaaacatt ctagctttga tttttctgaa gggaatacac   2160

ttgttttcaa ttttggggtt tttctttggg gcacttgctt gactctgtat gaacttgtga   2220

tccaaggaaa aaggagaaag aacagtgttg gcttttaaaa tcaggatggt tttatgtttg   2280

ctacgaaata aggcaagaat aaaaaattct tatttttatt tatttattta ttttttgaga   2340

tagagtctgg ctgtgttgcc caggatgcaa tggcgcaatc ttggctcact gcaacctctg   2400

ccttctgggt tcaagtgatt ctcctgcctc agcctcccaa gtagctggga ttacaggtac   2460

ctgccaccac gcctggctaa ttttttgtgt ttttagtaga gacagggttt caccacgttc   2520

gccaggctag tcttgaactg acctcaagtg atcctcccac ctcggcttcc caaagtgctg   2580

ggattacagg cgtgagccac cggccaatct ttttatcctt gagcaacttc gcttctttga   2640

gcctcattgg tgttctcaat tgtgaaatat ggataatagt atctgcccca tgggtatttt   2700

gagaaggttg aatgaacagg aaattattac aaagagccta gaggtgtctg atatatagta   2760

tgttccagta aatgttcact attcttagca tctcaggcag atgagctagt atagatagat   2820

gattaagtca gcttgcttca tagaaattag tgcaagaatt tgttagccta ccaactgata   2880

gtatcagact tggaaaataa atgaaattgg gccaggcgtg gtggctcacc cttgtaatcc   2940

cagcgctttc agaggccgag gcaggcggat cacctgaggt tgggagtttg agaccatcct   3000

gaccaacatg gagaaacccc gtctctactt aaaatacaaa attagcgggg cgtggtggcg   3060

catgcctgta atctcagcta ctctggaggc tgaggcagga gaattgcttg aacctgggag   3120

gcagaggggg tggcgagcca agattgcacc attgtactcc agcctaggca acaagagcga   3180

aactgtctca aaaaaaaaaa aaaaaaaaaa gtgaaattgc ttacccaaat ctacagttaa   3240

ctttcgtttt ttaatgcttg atgaatttgc atgtcattct tgggcagtgg ccatgctgtc   3300

ttctctgtat tgttccaatt tgggtatatg tgctgccaaa gtgagtactg cagaattatt   3360

tcttgagaga ggcacttaca tgtgctgatt ggcactaaag cagtggaatg ggaagaagag   3420

acttggaagg cagcccagac gatccaggcg tgtgctagat ggcaactgag gagcacggtg   3480

ctaccatctt tactggtgtt tccacctatg tgccaggggt tctgtgagct acctgagaat   3540

actgaagtat ataatgctct ggcacatagt taggcactaa tcagtggtat ttatcaaggt   3600

gattaaaagc agatttaaaa agcagctcac agttgggcgc ggtggctcac acctgtaatc   3660

ccagcacttt gggaggccga ggcgggtgga tcaccagagg tcagaagttc gagaccagcc   3720

tggccaacgt tgtgaaaccc tgtctctact aaaaatacaa aaattggcca cgtgtggtgg   3780

cgggcacctg taatcctagc tacttgggaa gctgagacag gagaattgct tgaacccggg   3840

aggtggaggt tgcagtgagc caagatcatg ccattgcact ccagcctggg caacaagagc   3900

gagactccat cttgaaaaaa aataaaataa taaaaagcag ctcatactag ggaacttggt   3960

aaagcaacct catgctgttg taggttgaaa gcctggtcag ctattctgca agacagtcaa   4020

aaattgttta cagggctgga cagcatattg ctattgaaaa atagctatta ggagaccttg   4080

cacaatttgt gaaacattgt taggctcatt gtactgtgta aaatcaggaa agaatttggg   4140

aacatactga tacaacaaaa agataggttg tcaaaccctc acttcaccag aaagctaaat   4200

taaccagata agtctttctg aaagttttag tgtcttagtt tgttcctgcg ctgtaacaga   4260

ataccttaga ctgggtaacc tataaataat aggaatttat ttctcacagt tttggaggct   4320

ggcaaatgca agatccaggt gctggtacgt tcagtgtctg gcaagggcgg ctttctggtc   4380

caagatggtg cctttttttc tgcatcttcc atagggaatg aacactcctt atggtagaag   4440

ggatggaagg accaggcttt tttttttttt ttttttggat acagcaggat cttgctctgt   4500

cgcccaggct ggagtgcagt ggcatgatta aggttcactg cagcctcaat ctcccactct   4560

ccagcgatca tcccacctca gcctcttgga tagctgggac cacaggcacg agctaccatg   4620

cctggctaat ttattttttg tagagacggg gtttcgccat gttgcccagg ctggtctgga   4680

atttctgacc tctagcagtc cacctgtttc cgcctcccaa atgctgagat tagaggcatg   4740

agtcactgca cccagcccgc agcctctttt ataagggcat taatcccctt catgagggat   4800

attctctcat gacttaatca cctgccaaag accccacctc ttaatactac atcagtgatg   4860

ggttcaatgt atcaattggg tgggaggggg cacattcaga ccatagcatc tagtcattct   4920

ggttttatta agatttatta gacctgaggc atgaaaaata gcatactgga tgggacttca   4980

gcatcgatga gttgccttag taatactgtt aataaaaagc actaaatatg cca          5033


<210>  8384
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  8384

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Glu Phe Glu Thr Ala Glu Thr Leu 
            20                  25                  30          


Leu Asn Ser Glu Val His Met Leu Leu Glu His Arg Lys Gln Gln Asn 
        35                  40                  45              


Glu Ser Ala Glu Asp Glu Gln Glu Leu Ser Glu Val Phe Met Lys Thr 
    50                  55                  60                  


Leu Asn Tyr Thr Ala Arg Phe Ser Arg Phe Lys Asn Arg Glu Thr Ile 
65                  70                  75                  80  


Ala Ser Val Arg Ser Leu Leu Leu Gln Lys Lys Leu His Lys Phe Glu 
                85                  90                  95      


Leu Ala Cys Leu Ala Asn Leu Cys Pro Glu Thr Ala Glu Glu Ser Lys 
            100                 105                 110         


Ala Leu Ile Pro Ser Leu Glu Gly Arg Phe Glu Asp Glu Glu Leu Gln 
        115                 120                 125             


Gln Ile Leu Asp Asp Ile Gln Thr Lys Arg Ser Phe Gln Tyr 
    130                 135                 140         


<210>  8385
<211>  1333
<212>  DNA
<213>  Homosapiens

<400>  8385
ggtgttctca attgtgaaat atggataata gtatctgccc catgggtatt ttgagaaggt     60

tgaatgaaca ggaaattatt acaaagagcc tagaggtgtc tgatatatag tatgttccag    120

taaatgttca ctattcttag catctcaggc agatgagcta gtatagatag atgattaagt    180

cagcttgctt catagaaatt agtgcaagaa tttgttagcc taccaactga tagtatcaga    240

cttggaaaat aaatgaaatt gggccaggcg tggtggctca cccttgtaat cccagcgctt    300

tcagaggccg aggcaggcgg atcacctgag gttgggagtt tgagaccatc ctgaccaaca    360

tggagaaacc ccgtctctac ttaaaataca aaattagcgg ggcgtggtgg cgcatgcctg    420

taatctcagc tactctggag gctgaggcag gagaattgct tgaacctggg aggcagaggg    480

ggtggcgagc caagattgca ccattgtact ccagcctagg caacaagagc gaaactgtct    540

caaaaaaaaa aaaaaaaaaa aagtgaaatt gcttacccaa atctacagtt aactttcgtt    600

ttttaatgct tgatgaattt gcatgtcatt cttgggcagt ggccatgctg tcttctctgt    660

attgttccaa tttgggtata tgtgctgcca aagtgagtac tgcagaatta tttcttgaga    720

gaggcactta catgtgctga ttggcactaa agcagtggaa tgggaagaag agacttggaa    780

ggcagcccag acgatccagg cgtgtgctag atggcaactg aggagcacgg tgctaccatc    840

tttactggtg tttccaccta tgtgccaggg gttctgtgag ctacctgaga atactgaagt    900

atataatgct ctggcacata gttaggcact aatcagtggt atttatcaag gtgattaaaa    960

gcagatttaa aaagcagctc acagttgggc gcggtggctc acacctgttt ccgcctccca   1020

aatgctgaga ttagaggcat gagtcactgc acccagcccg cagcctcttt tataagggca   1080

ttaatcccct tcatgaggga tattctctca tgacttaatc acctgccaaa gaccccacct   1140

cttaatacta catcagtgat gggttcaatg tatcaattgg gtgggagggg gcacattcag   1200

accatagcat ctagtcattc tggttttatt aagatttatt agacctgagg catgaaaaat   1260

agcatactgg atgggacttc agcatcgatg agttgcctta gtaatactgt taataaaaag   1320

cactaaatat gcc                                                      1333


<210>  8386
<211>  68
<212>  PRT
<213>  Homosapiens

<400>  8386

Met Glu Lys Pro Arg Leu Tyr Leu Lys Tyr Lys Ile Ser Gly Ala Trp 
1               5                   10                  15      


Trp Arg Met Pro Val Ile Ser Ala Thr Leu Glu Ala Glu Ala Gly Glu 
            20                  25                  30          


Leu Leu Glu Pro Gly Arg Gln Arg Gly Trp Arg Ala Lys Ile Ala Pro 
        35                  40                  45              


Leu Tyr Ser Ser Leu Gly Asn Lys Ser Glu Thr Val Ser Lys Lys Lys 
    50                  55                  60                  


Lys Lys Lys Lys 
65              


<210>  8387
<211>  2091
<212>  DNA
<213>  Homosapiens

<400>  8387
gtttgctacg aaataaggca agaataaaaa attcttattt ttatttattt atttattttt     60

tgagatagag tctggctgtg ttgcccagga tgcaatggcg caatcttggc tcactgcaac    120

ctctgccttc tgggttcaag tgattctcct gcctcagcct cccaagtagc tgggattaca    180

ggtacctgcc accacgcctg gctaattttt tgtgttttta gtagagacag ggtttcacca    240

cgttcgccag gctagtcttg aactgacctc aagtgatcct cccacctcgg cttcccaaag    300

tgctgggatt acaggcgtga gccaccggcc aatcttttta tccttgagca acttcgcttc    360

tttgagcctc attggtgttc tcaattgtga aatatggata atagtatctg ccccatgggt    420

attttgagaa ggttgaatga acaggaaatt attacaaaga gcctagaggt gtctgatata    480

tagtatgttc cagtaaatgt tcactattct tagcatctca ggcagatgag ctagtataga    540

tagatgatta agtcagcttg cttcatagaa attagtgcaa gaatttgtta gcctaccaac    600

tgatagtatc agacttggaa aataaatgaa attgggccag gcgtggtggc tcacccttgt    660

aatcccagcg ctttcagagg ccgaggcagg cggatcacct gaggttggga gtttgagacc    720

atcctgacca acatggagaa accccgtctc tacttaaaat acaaaattag cggggcgtgg    780

tggcgcatgc ctgtaatctc agctactctg gaggctgagg caggagaatt gcttgaacct    840

gggaggcaga gggggtggcg agccaagatt gcaccattgt actccagcct aggcaacaag    900

agcgaaactg tctcaaaaaa aaaaaaaaaa aaaaagtgaa attgcttacc caaatctaca    960

gttaactttc gttttttaat gcttgatgaa tttgcatgtc attcttgggc agtggccatg   1020

ctgtcttctc tgtattgttc caatttgggt atatgtgctg ccaaagtgag tactgcagaa   1080

ttatttcttg agagaggcac ttacatgtgc tgattggcac taaagcagtg gaatgggaag   1140

aagagacttg gaaggcagcc cagacgatcc aggcgtgtgc tagatggcaa ctgaggagca   1200

cggtgctacc atctttactg gtgtttccac ctatgtgcca ggggttctgt gagctacctg   1260

agaatactga agtatataat gctctggcac atagttaggc actaatcagt ggtatttatc   1320

aaggtgatta aaagcagatt taaaaagcag ctcacagttg ggcgcggtgg ctcacacctg   1380

taatcccagc actttgggag gccgaggcgg gtggatcacc agaggtcaga agttcgagac   1440

cagcctggcc aacgttgtga aaccctgtct ctactaaaaa tacaaaaatt ggccacgtgt   1500

ggtggcgggc acctgtaatc ctagctactt gggaagctga gacaggagaa ttgcttgaac   1560

ccgggaggtg gaggttgcat ggcatgatta aggttcactg cagcctcaat ctcccactct   1620

ccagcgatca tcccacctca gcctcttgga tagctgggac cacaggcacg agctaccatg   1680

cctggctaat ttattttttg tagagacggg gtttcgccat gttgcccagg ctggtctgga   1740

atttctgacc tctagcagtc cacctgtttc cgcctcccaa atgctgagat tagaggcatg   1800

agtcactgca cccagcccgc agcctctttt ataagggcat taatcccctt catgagggat   1860

attctctcat gacttaatca cctgccaaag accccacctc ttaatactac atcagtgatg   1920

ggttcaatgt atcaattggg tgggaggggg cacattcaga ccatagcatc tagtcattct   1980

ggttttatta agatttatta gacctgaggc atgaaaaata gcatactgga tgggacttca   2040

gcatcgatga gttgccttag taatactgtt aataaaaagc actaaatatg c            2091


<210>  8388
<211>  68
<212>  PRT
<213>  Homosapiens

<400>  8388

Met Glu Lys Pro Arg Leu Tyr Leu Lys Tyr Lys Ile Ser Gly Ala Trp 
1               5                   10                  15      


Trp Arg Met Pro Val Ile Ser Ala Thr Leu Glu Ala Glu Ala Gly Glu 
            20                  25                  30          


Leu Leu Glu Pro Gly Arg Gln Arg Gly Trp Arg Ala Lys Ile Ala Pro 
        35                  40                  45              


Leu Tyr Ser Ser Leu Gly Asn Lys Ser Glu Thr Val Ser Lys Lys Lys 
    50                  55                  60                  


Lys Lys Lys Lys 
65              


<210>  8389
<211>  1565
<212>  DNA
<213>  Homosapiens

<400>  8389
aactagacca gaagatagta gactttatag agaaagacca gttttaccta gatactaaag     60

gaagaattaa accgctgtta gtttgaaatg cttttttttt ttttttttaa atggagatag    120

ggtcttaact cttgtccagg ctggaggagt gcagtcgtac agtcatggct cactgaagtc    180

ttgaccccgc tgcctcagcc tcccaaataa ctggggccac aggtgtgcac cacaactctc    240

agctaatttt taaaattttt tatagaggtg gggttttact atgctgtcca gactggtctt    300

aaactcctgg gctcaagtga tccccctgcc ttggcctccc aaactggtga gattacaggc    360

atgagccacc acaactggcc tgaaattctt aaaggatggg agtgtcgatg acagcacctt    420

ggcatcgttg tgcctaacct gggagacgga agaagcacgc catgggaagt gtttacactt    480

ggggacaagt gctaagtatt gtggagccca tagccccttg agatagatgg ctactttgcc    540

tttcttcttg aactgtcttg cagaatgtgg atttggggta agtggtcttg aaggattcat    600

ttagtcaccc tcaaattaag atttttactt catctttctt gggcctgcac ctccaagata    660

acaaagaaga agcaatggtc gtgccaaaga ggtccacaac caggtgtgca ctgttcactg    720

cagcccattt gctgtatgaa ctgtggttgt tgtgtgccca atgacaaggc tactaagaaa    780

ttcatcattt gaaacgtaga ggccgcagca gtcagcgatg tttctgaaat gagcatcctt    840

gacgcctgtg tacttcccag gctggatgtg aagctacatt accatgtgag ttgtgccatt    900

cacagcacag tggtgaggaa ttgagctcat gaagcaggca aggaccgaac acctccaccc    960

caacgtagac ctgcaggtgc tgccccatga cctccaccaa agcccatata aggagcggag   1020

ttgttaagga ctgaagaaaa acttctctgg agaaaaataa aattgcaatt ctacttaaaa   1080

aaattttttt ttttttttac ttcataggcc aggcttgaag ttctgaacac tttgaagtct   1140

ccaattatga gagatccagt ctaagcctct ggcctgctaa ttagcaataa gtgctttatt   1200

tggaaggagg gagtcatcca ctcttgagcc actgcagtga agtcacttga tctcagtctg   1260

ggggaaaaca cttcaatagc taaacattct agctttgatt tttctgaagg gaatacactt   1320

gttttcaatt ttggggtttt tctttggggc acttgcttga ctctgtatga acttgtgatc   1380

caaggaaaaa ggagaaagaa cagtgttggc ttttaaaatc aggatggttt tatgtttgct   1440

acgaaataag gcaagaataa aaaattctta tttttattta tttatttatt ttttgagata   1500

gagtctggct ccaagattgc accattgtac tccagcctag gcaacaagag cgaaactgtc   1560

tcaaa                                                               1565


<210>  8390
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  8390

Met Lys Gln Ala Arg Thr Glu His Leu His Pro Asn Val Asp Leu Gln 
1               5                   10                  15      


Val Leu Pro His Asp Leu His Gln Ser Pro Tyr Lys Glu Arg Ser Cys 
            20                  25                  30          


<210>  8391
<211>  2292
<212>  DNA
<213>  Homosapiens

<400>  8391
aggcgtgagc cactgcgcct tggcaatttt tgtattttta gtagagacgg ggtttcgcca     60

tggtgctcag gctggtctcg aactcctcac gtcaagtgat tacccacctt ggcctctcag    120

agtgctggaa ttacaggtgt gagccactac acctggccgt ctagctattt ttaaatacta    180

gctacgtttg atcccttttt tcctgttgat tactctttga tttttgttgt ttatttgttt    240

ttgattattt tgattttttt tttttccttt tgattagctt gctactccag aaaaagcttc    300

ataagtttga gttggcctgt ttggccaacc tttgcccaga gactgctgag gagtccaagg    360

ctctaatccc aagcttggag ggacggtttg aagatgagga gctgcagcag attcttgatg    420

atatccagac aaagcgcagc tttcagtatt aatctccaaa catcactgct gctcggagaa    480

accacatccc caggcataac accaccttcc cactgtctgg ggctgacttg cacagaaatt    540

ctgttgaaga cagttgagaa ttcctttgga gaaaacagcc cagcttggcg tggggttagg    600

ttgctgtttc aaataactca caggcccagg tgacatggaa tcttggagca gccttgtgca    660

gtggcagcca gtggcttcct gaacgtgcct ctgcgaagtg tgagatgagg ggtcacataa    720

ccacactgtt gactacctca ttcctggttt ttggcctcca catcatcttt tttcttaata    780

tttcatgttt taatttcagg gtgtttatac tttttgaaac tagaccagaa gatagtagac    840

tttatagaga aagaccagtt ttacctagat actaaaggaa gaattaaacc gctgttagtt    900

tgaaatgctt tttttttttt tttttaaatg gagatagggt cttaactctt gtccaggctg    960

gaggagtgca gtcgtacagt catggctcac tgaagtcttg accccgctgc ctcagcctcc   1020

caaataactg gggccacagg tgtgcaccac aactctcagc taatttttaa aattttttat   1080

agaggtgggg ttttactatg ctgtccagac tggtcttaaa ctcctgggct caagtgatcc   1140

ccctgccttg gcctcccaaa ctggtgagat tacaggcatg agccaccaca actggcctga   1200

aattcttaaa ggatgggagt gtcgatgaca gcaccttggc atcgttgtgc ctaacctggg   1260

agacggaaga agcacgccat gggaagtgtt tacacttggg gacaagtgct aagtattgtg   1320

gagcccatag ccccttgaga tagatggcta ctttgccttt cttcttgaac tgtcttgcag   1380

aatgtggatt tggggtaagt ggtcttgaag gattcattta gtcaccctca aattaagatt   1440

tttacttcat ctttcttggg cctgcacctc caagataaca aagaagaagc aatggtcgtg   1500

ccaaagaggt ccacaaccag gtgtgcactg ttcactgcag cccatttgct gtatgaactg   1560

tggttgttgt gtgcccaatg acaaggctac taagaaattc atcatttgaa acgtagaggc   1620

cgcagcagtc agcgatgttt ctgaaatgag catccttgac gcctgtgtac ttcccaggct   1680

ggatgtgaag ctacattacc atgtgagttg tgccattcac agcacagtgg tgaggaattg   1740

agctcatgaa gcaggcaagg accgaacacc tccaccccaa cgtagacctg caggtgctgc   1800

cccatgacct ccaccaaagc ccatataagg agcggagttg ttaaggactg aagaaaaact   1860

tctctggaga aaaataaaat tgcaattcta cttaaaaaaa tttttttttt tttttacttc   1920

ataggccagg cttgaagttc tgaacacttt gaagtctcca attatgagag atccagtcta   1980

agcctctggc ctgctaatta gcaataagtg ctttatttgg aaggagggag tcatccactc   2040

ttgagccact gcagtgaagt cacttgatct cagtctgggg gaaaacactt caatagctaa   2100

acattctagc tttgattttt ctgaagggaa tacacttgtt ttcaattttg gggtttttct   2160

ttggggcact tgcttgactc tgtatgaact tgtgatccaa ggaaaaagga gaaagaacag   2220

tgttggcttt taaaatcagg atggttttat gtttgctacg aaataaggca agaataaaaa   2280

attcttattt tt                                                       2292


<210>  8392
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  8392

Met Arg Ser Cys Ser Arg Phe Leu Met Ile Ser Arg Gln Ser Ala Ala 
1               5                   10                  15      


Phe Ser Ile Asn Leu Gln Thr Ser Leu Leu Leu Gly Glu Thr Thr Ser 
            20                  25                  30          


Pro Gly Ile Thr Pro Pro Ser His Cys Leu Gly Leu Thr Cys Thr Glu 
        35                  40                  45              


Ile Leu Leu Lys Thr Val Glu Asn Ser Phe Gly Glu Asn Ser Pro Ala 
    50                  55                  60                  


Trp Arg Gly Val Arg Leu Leu Phe Gln Ile Thr His Arg Pro Arg 
65                  70                  75                  


<210>  8393
<211>  2421
<212>  DNA
<213>  Homosapiens

<400>  8393
cgcgtggtcg ccgcaggcct ggcgttatgc gcgcttcgcc caaggccctg cctcagcggc     60

ggcttgggca agccccagcg cggcgtgggg ctggggaggg aacatggcct tgggagggac    120

catggccttg ggagggaccg cctgggcaac tgggttattt tatgtgataa actgcgaagt    180

tccggggacc tgtgtcaaag ataaacaaag ccggacactc aggtgagttt gaaacagctg    240

agacacttct aaattcagaa gttcatatgc ttctggaaca tcgaaagcag cagaatgaga    300

gtgcagagga cgaacaggag ctctcagaag tcttcatgaa aacattaaac tacacagccc    360

gtttcagtcg tttcaaaaac agagagacca ttgccagtgt tcgtagcttg ctactccaga    420

aaaagcttca taagtttgag ttggcctgtt tggccaacct ttgcccagag actgctgagg    480

agtccaaggc tctaatccca agcttggagg gacggtttga agatgaggag ctgcagcaga    540

ttcttgatga tatccagaca aagcgcagct ttcagtatta atctccaaac atcactgctg    600

ctcggagaaa ccacatcccc aggcataaca ccaccttccc actgtctggg gctgacttgc    660

acagaaattc tgttgaagac agttgagaat tcctttggag aaaacagccc agcttggcgt    720

ggggttaggt tgctgtttca aataactcac aggcccaggt gacatggaat cttggagcag    780

ccttgtgcag tggcagccag tggcttcctg aacgtgcctc tgcgaagtgt gagatgaggg    840

gtcacataac cacactgttg actacctcat tcctggtttt tggcctccac atcatctttt    900

ttcttaatat ttcatgtttt aatttcaggg tgtttatact ttttgaaact agaccagaag    960

atagtagact ttatagagaa agaccagttt tacctagata ctaaaggaag aattaaaccg   1020

ctgttagttt gaaatgcttt tttttttttt ttttaaatgg agatagggtc ttaactcttg   1080

tccaggctgg aggagtgcag tcgtacagtc atggctcact gaagtcttga ccccgctgcc   1140

tcagcctccc aaataactgg ggccacaggt gtgcaccaca actctcagct aatttttaaa   1200

attttttata gaggtggggt tttactatgc tgtccagact ggtcttaaac tcctgggctc   1260

aagtgatccc cctgccttgg cctcccaaac tggtgagatt acaggcatga gccaccacaa   1320

ctggcctgaa attcttaaag gatgggagtg tcgatgacag caccttggca tcgttgtgcc   1380

taacctggga gacggaagaa gcacgccatg ggaagtgttt acacttgggg acaagtgcta   1440

agtattgtgg agcccatagc cccttgagat agatggctac tttgcctttc ttcttgaact   1500

gtcttgcaga atgtggattt ggggtaagtg gtcttgaagg attcatttag tcaccctcaa   1560

attaagattt ttacttcatc tttcttgggc ctgcacctcc aagataacaa agaagaagca   1620

atggtcgtgc caaagaggtc cacaaccagg tgtgcactgt tcactgcagc ccatttgctg   1680

tatgaactgt ggttgttgtg tgcccaatga caaggctact aagaaattca tcatttgaaa   1740

cgtagaggcc gcagcagtca gcgatgtttc tgaaatgagc atccttgacg cctgtgtact   1800

tcccaggctg gatgtgaagc tacattacca tgtgagttgt gccattcaca gcacagtggt   1860

gaggaattga gctcatgaag caggcaagga ccgaacacct ccaccccaac gtagacctgc   1920

aggtgctgcc ccatgacctc caccaaagcc catataagga gcggagttgt taaggactga   1980

agaaaaactt ctctggagaa aaataaaatt gcaattctac ttaaaaaaat tttttttttt   2040

ttttacttca taggccaggc ttgaagttct gaacactttg aagtctccaa ttatgagaga   2100

tccagtctaa gcctctggcc tgctaattag caataagtgc tttatttgga aggagggagt   2160

catccactct tgagccactg cagtgaagtc acttgatctc agtctggggg aaaacacttc   2220

aatagctaaa cattctagct ttgatttttc tgaagggaat acacttgttt tcaattttgg   2280

ggtttttctt tggggcactt gcttgactct gtatgaactt gtgatccaag gaaaaaggag   2340

aaagaacagt gttggctttt aaaatcagga tggttttatg tttgctacga aataaggcaa   2400

gaataaaaaa ttcttatttt t                                             2421


<210>  8394
<211>  104
<212>  PRT
<213>  Homosapiens

<400>  8394

Met Leu Leu Glu His Arg Lys Gln Gln Asn Glu Ser Ala Glu Asp Glu 
1               5                   10                  15      


Gln Glu Leu Ser Glu Val Phe Met Lys Thr Leu Asn Tyr Thr Ala Arg 
            20                  25                  30          


Phe Ser Arg Phe Lys Asn Arg Glu Thr Ile Ala Ser Val Arg Ser Leu 
        35                  40                  45              


Leu Leu Gln Lys Lys Leu His Lys Phe Glu Leu Ala Cys Leu Ala Asn 
    50                  55                  60                  


Leu Cys Pro Glu Thr Ala Glu Glu Ser Lys Ala Leu Ile Pro Ser Leu 
65                  70                  75                  80  


Glu Gly Arg Phe Glu Asp Glu Glu Leu Gln Gln Ile Leu Asp Asp Ile 
                85                  90                  95      


Gln Thr Lys Arg Ser Phe Gln Tyr 
            100                 


<210>  8395
<211>  2011
<212>  DNA
<213>  Homosapiens

<400>  8395
cgcgcggcgc ggcgcggcga tggcggcggg tggcagcgat ccgcgggctg gcgacgtaga     60

ggaggacgcc tcacagctca tctttcctaa agcttggagg gacggtttga agatgaggag    120

ctgcagcaga ttcttgatga tatccagaca aagcgcagct ttcagtatta atctccaaac    180

atcactgctg ctcggagaaa ccacatcccc aggcataaca ccaccttccc actgtctggg    240

gctgacttgc acagaaattc tgttgaagac agttgagaat tcctttggag aaaacagccc    300

agcttggcgt ggggttaggt tgctgtttca aataactcac aggcccaggt gacatggaat    360

cttggagcag ccttgtgcag tggcagccag tggcttcctg aacgtgcctc tgcgaagtgt    420

gagatgaggg gtcacataac cacactgttg actacctcat tcctggtttt tggcctccac    480

atcatctttt ttcttaatat ttcatgtttt aatttcaggg tgtttatact ttttgaaact    540

agaccagaag atagtagact ttatagagaa agaccagttt tacctagata ctaaaggaag    600

aattaaaccg ctgttagttt gaaatgcttt tttttttttt ttttaaatgg agatagggtc    660

ttaactcttg tccaggctgg aggagtgcag tcgtacagtc atggctcact gaagtcttga    720

ccccgctgcc tcagcctccc aaataactgg ggccacaggt gtgcaccaca actctcagct    780

aatttttaaa attttttata gaggtggggt tttactatgc tgtccagact ggtcttaaac    840

tcctgggctc aagtgatccc cctgccttgg cctcccaaac tggtgagatt acaggcatga    900

gccaccacaa ctggcctgaa attcttaaag gatgggagtg tcgatgacag caccttggca    960

tcgttgtgcc taacctggga gacggaagaa gcacgccatg ggaagtgttt acacttgggg   1020

acaagtgcta agtattgtgg agcccatagc cccttgagat agatggctac tttgcctttc   1080

ttcttgaact gtcttgcaga atgtggattt ggggtaagtg gtcttgaagg attcatttag   1140

tcaccctcaa attaagattt ttacttcatc tttcttgggc ctgcacctcc aagataacaa   1200

agaagaagca atggtcgtgc caaagaggtc cacaaccagg tgtgcactgt tcactgcagc   1260

ccatttgctg tatgaactgt ggttgttgtg tgcccaatga caaggctact aagaaattca   1320

tcatttgaaa cgtagaggcc gcagcagtca gcgatgtttc tgaaatgagc atccttgacg   1380

cctgtgtact tcccaggctg gatgtgaagc tacattacca tgtgagttgt gccattcaca   1440

gcacagtggt gaggaattga gctcatgaag caggcaagga ccgaacacct ccaccccaac   1500

gtagacctgc aggtgctgcc ccatgacctc caccaaagcc catataagga gcggagttgt   1560

taaggactga agaaaaactt ctctggagaa aaataaaatt gcaattctac ttaaaaaaat   1620

tttttttttt ttttacttca taggccaggc ttgaagttct gaacactttg aagtctccaa   1680

ttatgagaga tccagtctaa gcctctggcc tgctaattag caataagtgc tttatttgga   1740

aggagggagt catccactct tgagccactg cagtgaagtc acttgatctc agtctggggg   1800

aaaacacttc aatagctaaa cattctagct ttgatttttc tgaagggaat acacttgttt   1860

tcaattttgg ggtttttctt tggggcactt gcttgactct gtatgaactt gtgatccaag   1920

gaaaaaggag aaagaacagt gttggctttt aaaatcagga tggttttatg tttgctacga   1980

aataaggcaa gaataaaaaa ttcttatttt t                                  2011


<210>  8396
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  8396

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Ala Trp Arg Asp Gly Leu Lys Met 
            20                  25                  30          


Arg Ser Cys Ser Arg Phe Leu Met Ile Ser Arg Gln Ser Ala Ala Phe 
        35                  40                  45              


Ser Ile Asn Leu Gln Thr Ser Leu Leu Leu Gly Glu Thr Thr Ser Pro 
    50                  55                  60                  


Gly Ile Thr Pro Pro Ser His Cys Leu Gly Leu Thr Cys Thr Glu Ile 
65                  70                  75                  80  


Leu Leu Lys Thr Val Glu Asn Ser Phe Gly Glu Asn Ser Pro Ala Trp 
                85                  90                  95      


Arg Gly Val Arg Leu Leu Phe Gln Ile Thr His Arg Pro Arg 
            100                 105                 110 


<210>  8397
<211>  2109
<212>  DNA
<213>  Homosapiens

<400>  8397
ggcgcgcggc gcggcgcggc gatggcggcg ggtggcagcg atccgcgggc tggcgacgta     60

gaggaggacg cctcacagct catctttcct aaagcttgct actccagaaa aagcttcata    120

agtttgagtt ggcctgtttg gccaaccttt gcccagagac tgctgaggag tccaaggctc    180

taatcccaag cttggaggga cggtttgaag atgaggagct gcagcagatt cttgatgata    240

tccagacaaa gcgcagcttt cagtattaat ctccaaacat cactgctgct cggagaaacc    300

acatccccag gcataacacc accttcccac tgtctggggc tgacttgcac agaaattctg    360

ttgaagacag ttgagaattc ctttggagaa aacagcccag cttggcgtgg ggttaggttg    420

ctgtttcaaa taactcacag gcccaggtga catggaatct tggagcagcc ttgtgcagtg    480

gcagccagtg gcttcctgaa cgtgcctctg cgaagtgtga gatgaggggt cacataacca    540

cactgttgac tacctcattc ctggtttttg gcctccacat catctttttt cttaatattt    600

catgttttaa tttcagggtg tttatacttt ttgaaactag accagaagat agtagacttt    660

atagagaaag accagtttta cctagatact aaaggaagaa ttaaaccgct gttagtttga    720

aatgcttttt tttttttttt ttaaatggag atagggtctt aactcttgtc caggctggag    780

gagtgcagtc gtacagtcat ggctcactga agtcttgacc ccgctgcctc agcctcccaa    840

ataactgggg ccacaggtgt gcaccacaac tctcagctaa tttttaaaat tttttataga    900

ggtggggttt tactatgctg tccagactgg tcttaaactc ctgggctcaa gtgatccccc    960

tgccttggcc tcccaaactg gtgagattac aggcatgagc caccacaact ggcctgaaat   1020

tcttaaagga tgggagtgtc gatgacagca ccttggcatc gttgtgccta acctgggaga   1080

cggaagaagc acgccatggg aagtgtttac acttggggac aagtgctaag tattgtggag   1140

cccatagccc cttgagatag atggctactt tgcctttctt cttgaactgt cttgcagaat   1200

gtggatttgg ggtaagtggt cttgaaggat tcatttagtc accctcaaat taagattttt   1260

acttcatctt tcttgggcct gcacctccaa gataacaaag aagaagcaat ggtcgtgcca   1320

aagaggtcca caaccaggtg tgcactgttc actgcagccc atttgctgta tgaactgtgg   1380

ttgttgtgtg cccaatgaca aggctactaa gaaattcatc atttgaaacg tagaggccgc   1440

agcagtcagc gatgtttctg aaatgagcat ccttgacgcc tgtgtacttc ccaggctgga   1500

tgtgaagcta cattaccatg tgagttgtgc cattcacagc acagtggtga ggaattgagc   1560

tcatgaagca ggcaaggacc gaacacctcc accccaacgt agacctgcag gtgctgcccc   1620

atgacctcca ccaaagccca tataaggagc ggagttgtta aggactgaag aaaaacttct   1680

ctggagaaaa ataaaattgc aattctactt aaaaaaattt tttttttttt ttacttcata   1740

ggccaggctt gaagttctga acactttgaa gtctccaatt atgagagatc cagtctaagc   1800

ctctggcctg ctaattagca ataagtgctt tatttggaag gagggagtca tccactcttg   1860

agccactgca gtgaagtcac ttgatctcag tctgggggaa aacacttcaa tagctaaaca   1920

ttctagcttt gatttttctg aagggaatac acttgttttc aattttgggg tttttctttg   1980

gggcacttgc ttgactctgt atgaacttgt gatccaagga aaaaggagaa agaacagtgt   2040

tggcttttaa aatcaggatg gttttatgtt tgctacgaaa taaggcaaga ataaaaaatt   2100

cttattttt                                                           2109


<210>  8398
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  8398

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Ala Cys Tyr Ser Arg Lys Ser Phe 
            20                  25                  30          


Ile Ser Leu Ser Trp Pro Val Trp Pro Thr Phe Ala Gln Arg Leu Leu 
        35                  40                  45              


Arg Ser Pro Arg Leu 
    50              


<210>  8399
<211>  2200
<212>  DNA
<213>  Homosapiens

<400>  8399
ggtggtggcg cgcggcgcgg cgcggcgatg gcggcgggtg gcagcgatcc gcgggctggc     60

gacgtagagg aggacgcctc acagctcatc tttcctaaag agtttgaaac agctgagaca    120

cttctaaatt cagaagttca tatgcttctg gaacatcgaa agcagcagaa tgagagtgca    180

gaggacgaac aggagctctc agaagtcttc atgaaaacat taaactacac agcccgtttc    240

agtcgtttca aaaacagaga gaccattgcc agtgttcgta gcttggaggg acggtttgaa    300

gatgaggagc tgcagcagat tcttgatgat atccagacaa agcgcagctt tcagtattaa    360

tctccaaaca tcactgctgc tcggagaaac cacatcccca ggcataacac caccttccca    420

ctgtctgggg ctgacttgca cagaaattct gttgaagaca gttgagaatt cctttggaga    480

aaacagccca gcttggcgtg gggttaggtt gctgtttcaa ataactcaca ggcccaggtg    540

acatggaatc ttggagcagc cttgtgcagt ggcagccagt ggcttcctga acgtgcctct    600

gcgaagtgtg agatgagggg tcacataacc acactgttga ctacctcatt cctggttttt    660

ggcctccaca tcatcttttt tcttaatatt tcatgtttta atttcagggt gtttatactt    720

tttgaaacta gaccagaaga tagtagactt tatagagaaa gaccagtttt acctagatac    780

taaaggaaga attaaaccgc tgttagtttg aaatgctttt tttttttttt tttaaatgga    840

gatagggtct taactcttgt ccaggctgga ggagtgcagt cgtacagtca tggctcactg    900

aagtcttgac cccgctgcct cagcctccca aataactggg gccacaggtg tgcaccacaa    960

ctctcagcta atttttaaaa ttttttatag aggtggggtt ttactatgct gtccagactg   1020

gtcttaaact cctgggctca agtgatcccc ctgccttggc ctcccaaact ggtgagatta   1080

caggcatgag ccaccacaac tggcctgaaa ttcttaaagg atgggagtgt cgatgacagc   1140

accttggcat cgttgtgcct aacctgggag acggaagaag cacgccatgg gaagtgttta   1200

cacttgggga caagtgctaa gtattgtgga gcccatagcc ccttgagata gatggctact   1260

ttgcctttct tcttgaactg tcttgcagaa tgtggatttg gggtaagtgg tcttgaagga   1320

ttcatttagt caccctcaaa ttaagatttt tacttcatct ttcttgggcc tgcacctcca   1380

agataacaaa gaagaagcaa tggtcgtgcc aaagaggtcc acaaccaggt gtgcactgtt   1440

cactgcagcc catttgctgt atgaactgtg gttgttgtgt gcccaatgac aaggctacta   1500

agaaattcat catttgaaac gtagaggccg cagcagtcag cgatgtttct gaaatgagca   1560

tccttgacgc ctgtgtactt cccaggctgg atgtgaagct acattaccat gtgagttgtg   1620

ccattcacag cacagtggtg aggaattgag ctcatgaagc aggcaaggac cgaacacctc   1680

caccccaacg tagacctgca ggtgctgccc catgacctcc accaaagccc atataaggag   1740

cggagttgtt aaggactgaa gaaaaacttc tctggagaaa aataaaattg caattctact   1800

taaaaaaatt tttttttttt tttacttcat aggccaggct tgaagttctg aacactttga   1860

agtctccaat tatgagagat ccagtctaag cctctggcct gctaattagc aataagtgct   1920

ttatttggaa ggagggagtc atccactctt gagccactgc agtgaagtca cttgatctca   1980

gtctggggga aaacacttca atagctaaac attctagctt tgatttttct gaagggaata   2040

cacttgtttt caattttggg gtttttcttt ggggcacttg cttgactctg tatgaacttg   2100

tgatccaagg aaaaaggaga aagaacagtg ttggctttta aaatcaggat ggttttatgt   2160

ttgctacgaa ataaggcaag aataaaaaat tcttattttt                         2200


<210>  8400
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  8400

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Glu Phe Glu Thr Ala Glu Thr Leu 
            20                  25                  30          


Leu Asn Ser Glu Val His Met Leu Leu Glu His Arg Lys Gln Gln Asn 
        35                  40                  45              


Glu Ser Ala Glu Asp Glu Gln Glu Leu Ser Glu Val Phe Met Lys Thr 
    50                  55                  60                  


Leu Asn Tyr Thr Ala Arg Phe Ser Arg Phe Lys Asn Arg Glu Thr Ile 
65                  70                  75                  80  


Ala Ser Val Arg Ser Leu Glu Gly Arg Phe Glu Asp Glu Glu Leu Gln 
                85                  90                  95      


Gln Ile Leu Asp Asp Ile Gln Thr Lys Arg Ser Phe Gln Tyr 
            100                 105                 110 


<210>  8401
<211>  2317
<212>  DNA
<213>  Homosapiens

<400>  8401
gcttctgctt ccggcggcgc tggtggtggc gcgcggcgcg gcgcggcgat ggcggcgggt     60

ggcagcgatc cgcgggctgg cgacgtagag gaggacgcct cacagctcat ctttcctaaa    120

gagtttgaaa cagctgagac acttctaaat tcagaagttc atatgcttct ggaacatcga    180

aagcagcaga atgagagtgc agaggacgaa caggagctct cagaagtctt catgaaaaca    240

ttaaactaca cagcccgttt cagtcgtttc aaaaacagag agaccattgc cagtgttcgt    300

agcttgctac tccagaaaaa gcttcataag tttgagttgg cctgtttggc caacctttgc    360

ccagagactg ctgaggagtc caaggctcta atcccaagct tggagggacg gtttgaagat    420

gaggagctgc agcagattct tgatgatatc cagacaaagc gcagctttca gtattaatct    480

ccaaacatca ctgctgctcg gagaaaccac atccccaggc ataacaccac cttcccactg    540

tctggggctg acttgcacag aaattctgtt gaagacagtt gagaattcct ttggagaaaa    600

cagcccagct tggcgtgggg ttaggttgct gtttcaaata actcacaggc ccaggtgaca    660

tggaatcttg gagcagcctt gtgcagtggc agccagtggc ttcctgaacg tgcctctgcg    720

aagtgtgaga tgaggggtca cataaccaca ctgttgacta cctcattcct ggtttttggc    780

ctccacatca tcttttttct taatatttca tgttttaatt tcagggtgtt tatacttttt    840

gaaactagac cagaagatag tagactttat agagaaagac cagttttacc tagatactaa    900

aggaagaatt aaaccgctgt tagtttgaaa tgcttttttt tttttttttt aaatggagat    960

agggtcttaa ctcttgtcca ggctggagga gtgcagtcgt acagtcatgg ctcactgaag   1020

tcttgacccc gctgcctcag cctcccaaat aactggggcc acaggtgtgc accacaactc   1080

tcagctaatt tttaaaattt tttatagagg tggggtttta ctatgctgtc cagactggtc   1140

ttaaactcct gggctcaagt gatccccctg ccttggcctc ccaaactggt gagattacag   1200

gcatgagcca ccacaactgg cctgaaattc ttaaaggatg ggagtgtcga tgacagcacc   1260

ttggcatcgt tgtgcctaac ctgggagacg gaagaagcac gccatgggaa gtgtttacac   1320

ttggggacaa gtgctaagta ttgtggagcc catagcccct tgagatagat ggctactttg   1380

cctttcttct tgaactgtct tgcagaatgt ggatttgggg taagtggtct tgaaggattc   1440

atttagtcac cctcaaatta agatttttac ttcatctttc ttgggcctgc acctccaaga   1500

taacaaagaa gaagcaatgg tcgtgccaaa gaggtccaca accaggtgtg cactgttcac   1560

tgcagcccat ttgctgtatg aactgtggtt gttgtgtgcc caatgacaag gctactaaga   1620

aattcatcat ttgaaacgta gaggccgcag cagtcagcga tgtttctgaa atgagcatcc   1680

ttgacgcctg tgtacttccc aggctggatg tgaagctaca ttaccatgtg agttgtgcca   1740

ttcacagcac agtggtgagg aattgagctc atgaagcagg caaggaccga acacctccac   1800

cccaacgtag acctgcaggt gctgccccat gacctccacc aaagcccata taaggagcgg   1860

agttgttaag gactgaagaa aaacttctct ggagaaaaat aaaattgcaa ttctacttaa   1920

aaaaattttt tttttttttt acttcatagg ccaggcttga agttctgaac actttgaagt   1980

ctccaattat gagagatcca gtctaagcct ctggcctgct aattagcaat aagtgcttta   2040

tttggaagga gggagtcatc cactcttgag ccactgcagt gaagtcactt gatctcagtc   2100

tgggggaaaa cacttcaata gctaaacatt ctagctttga tttttctgaa gggaatacac   2160

ttgttttcaa ttttggggtt tttctttggg gcacttgctt gactctgtat gaacttgtga   2220

tccaaggaaa aaggagaaag aacagtgttg gcttttaaaa tcaggatggt tttatgtttg   2280

ctacgaaata aggcaagaat aaaaaattct tattttt                            2317


<210>  8402
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  8402

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Glu Phe Glu Thr Ala Glu Thr Leu 
            20                  25                  30          


Leu Asn Ser Glu Val His Met Leu Leu Glu His Arg Lys Gln Gln Asn 
        35                  40                  45              


Glu Ser Ala Glu Asp Glu Gln Glu Leu Ser Glu Val Phe Met Lys Thr 
    50                  55                  60                  


Leu Asn Tyr Thr Ala Arg Phe Ser Arg Phe Lys Asn Arg Glu Thr Ile 
65                  70                  75                  80  


Ala Ser Val Arg Ser Leu Leu Leu Gln Lys Lys Leu His Lys Phe Glu 
                85                  90                  95      


Leu Ala Cys Leu Ala Asn Leu Cys Pro Glu Thr Ala Glu Glu Ser Lys 
            100                 105                 110         


Ala Leu Ile Pro Ser Leu Glu Gly Arg Phe Glu Asp Glu Glu Leu Gln 
        115                 120                 125             


Gln Ile Leu Asp Asp Ile Gln Thr Lys Arg Ser Phe Gln Tyr 
    130                 135                 140         


<210>  8403
<211>  1893
<212>  DNA
<213>  Homosapiens

<400>  8403
aggcgtgagc cactgcgcct tggcaatttt tgtattttta gtagagacgg ggtttcgcca     60

tggtgctcag gctggtctcg aactcctcac gtcaagtgat tacccacctt ggcctctcag    120

agtgctggaa ttacaggtgt gagccactac acctggccgt ctagctattt ttaaatacta    180

gctacgtttg atcccttttt tcctgttgat tactctttga tttttgttgt ttatttgttt    240

ttgattattt tgattttttt tttttccttt tgattagctt gctactccag aaaaagcttc    300

ataagtttga gttggcctgt ttggccaacc tttgcccaga gactgctgag gagtccaagg    360

ctctaatccc aagcttggag ggacggtttg aagatgagga gctgcagcag attcttgatg    420

atatccagac aaagcgcagc tttcagtatt aatctccaaa catcactgct gctcggagaa    480

accacatccc caggcataac accaccttcc cactgtctgg ggctgacttg cacagaaatt    540

ctgttgaaga cagttgagaa ttcctttgga gaaaacagcc cagcttggcg tggggttagg    600

ttgctgtttc aaataactca caggcccagg tgacatggaa tcttggagca gccttgtgca    660

gtggcagcca gtggcttcct gaacgtgcct ctgcgaagtg tgagatgagg ggtcacataa    720

ccacactgtt gactacctca ttcctggttt ttggcctcca catcatcttt tttcttaata    780

tttcatgttt taatttcagg gtgtttatac tttttgaaac tagaccagaa gatagtagac    840

tttatagaga aagaccagtt ttacctagat actaaaggaa gaattaaacc gctgttagtt    900

tgaaatgctt tttttttttt tttttaaatg gagatagggt cttaactctt gtccaggctg    960

gaggagtgca gtcgtacagt catggctcac tgaagtcttg accccgctgc ctcagcctcc   1020

caaataactg gggccacagg tgtgcaccac aactctcagc taatttttaa aattttttat   1080

agaggtgggg ttttactatg ctgtccagac tggtcttaaa ctcctgggct caagtgatcc   1140

ccctgccttg gcctcccaaa ctggtgagat tacaggcatg agccaccaca actggcctga   1200

aattcttaaa ggatgggagt gtcgatgaca gcaccttggc atcgttgtgc ctaacctggg   1260

agacggaaga agcacgccat gggaagtgtt tacacttggg gacaagtgct aagtattgtg   1320

gagcccatag ccccttgaga tagatggcta ctttgccttt cttcttgaac tgtcttgcag   1380

aatgtggatt tggggtaagt ggtcttgaag gattcattta gtcaccctca aattaagatt   1440

tttacttcat ctttcttggg cctgcacctc caagataaca aagaagaagc aatggtcgtg   1500

ccaaagaggt ccacaaccag gtgtgcactg ttcactgcag cccatttgct gtatgaactg   1560

tggttgttgt gtgcccaatg acaaggctac taagaaattc atcatttgaa acgtagaggc   1620

cgcagcagtc agcgatgttt ctgaaatgag catccttgac gcctgtgtac ttcccaggct   1680

ggatgtgaag ctacattacc atgtgagttg tgccattcac agcacagtgg tgaggaattg   1740

agctcatgaa gcaggcaagg accgaacacc tccaccccaa cgtagacctg caggtgctgc   1800

cccatgacct ccaccaaagc ccatataagg agcggagttg ttaaggactg aagaaaaact   1860

tctctggaga aaaataaaat tgcaattcta ctt                                1893


<210>  8404
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  8404

Met Arg Ser Cys Ser Arg Phe Leu Met Ile Ser Arg Gln Ser Ala Ala 
1               5                   10                  15      


Phe Ser Ile Asn Leu Gln Thr Ser Leu Leu Leu Gly Glu Thr Thr Ser 
            20                  25                  30          


Pro Gly Ile Thr Pro Pro Ser His Cys Leu Gly Leu Thr Cys Thr Glu 
        35                  40                  45              


Ile Leu Leu Lys Thr Val Glu Asn Ser Phe Gly Glu Asn Ser Pro Ala 
    50                  55                  60                  


Trp Arg Gly Val Arg Leu Leu Phe Gln Ile Thr His Arg Pro Arg 
65                  70                  75                  


<210>  8405
<211>  2022
<212>  DNA
<213>  Homosapiens

<400>  8405
cgcgtggtcg ccgcaggcct ggcgttatgc gcgcttcgcc caaggccctg cctcagcggc     60

ggcttgggca agccccagcg cggcgtgggg ctggggaggg aacatggcct tgggagggac    120

catggccttg ggagggaccg cctgggcaac tgggttattt tatgtgataa actgcgaagt    180

tccggggacc tgtgtcaaag ataaacaaag ccggacactc aggtgagttt gaaacagctg    240

agacacttct aaattcagaa gttcatatgc ttctggaaca tcgaaagcag cagaatgaga    300

gtgcagagga cgaacaggag ctctcagaag tcttcatgaa aacattaaac tacacagccc    360

gtttcagtcg tttcaaaaac agagagacca ttgccagtgt tcgtagcttg ctactccaga    420

aaaagcttca taagtttgag ttggcctgtt tggccaacct ttgcccagag actgctgagg    480

agtccaaggc tctaatccca agcttggagg gacggtttga agatgaggag ctgcagcaga    540

ttcttgatga tatccagaca aagcgcagct ttcagtatta atctccaaac atcactgctg    600

ctcggagaaa ccacatcccc aggcataaca ccaccttccc actgtctggg gctgacttgc    660

acagaaattc tgttgaagac agttgagaat tcctttggag aaaacagccc agcttggcgt    720

ggggttaggt tgctgtttca aataactcac aggcccaggt gacatggaat cttggagcag    780

ccttgtgcag tggcagccag tggcttcctg aacgtgcctc tgcgaagtgt gagatgaggg    840

gtcacataac cacactgttg actacctcat tcctggtttt tggcctccac atcatctttt    900

ttcttaatat ttcatgtttt aatttcaggg tgtttatact ttttgaaact agaccagaag    960

atagtagact ttatagagaa agaccagttt tacctagata ctaaaggaag aattaaaccg   1020

ctgttagttt gaaatgcttt tttttttttt ttttaaatgg agatagggtc ttaactcttg   1080

tccaggctgg aggagtgcag tcgtacagtc atggctcact gaagtcttga ccccgctgcc   1140

tcagcctccc aaataactgg ggccacaggt gtgcaccaca actctcagct aatttttaaa   1200

attttttata gaggtggggt tttactatgc tgtccagact ggtcttaaac tcctgggctc   1260

aagtgatccc cctgccttgg cctcccaaac tggtgagatt acaggcatga gccaccacaa   1320

ctggcctgaa attcttaaag gatgggagtg tcgatgacag caccttggca tcgttgtgcc   1380

taacctggga gacggaagaa gcacgccatg ggaagtgttt acacttgggg acaagtgcta   1440

agtattgtgg agcccatagc cccttgagat agatggctac tttgcctttc ttcttgaact   1500

gtcttgcaga atgtggattt ggggtaagtg gtcttgaagg attcatttag tcaccctcaa   1560

attaagattt ttacttcatc tttcttgggc ctgcacctcc aagataacaa agaagaagca   1620

atggtcgtgc caaagaggtc cacaaccagg tgtgcactgt tcactgcagc ccatttgctg   1680

tatgaactgt ggttgttgtg tgcccaatga caaggctact aagaaattca tcatttgaaa   1740

cgtagaggcc gcagcagtca gcgatgtttc tgaaatgagc atccttgacg cctgtgtact   1800

tcccaggctg gatgtgaagc tacattacca tgtgagttgt gccattcaca gcacagtggt   1860

gaggaattga gctcatgaag caggcaagga ccgaacacct ccaccccaac gtagacctgc   1920

aggtgctgcc ccatgacctc caccaaagcc catataagga gcggagttgt taaggactga   1980

agaaaaactt ctctggagaa aaataaaatt gcaattctac tt                      2022


<210>  8406
<211>  104
<212>  PRT
<213>  Homosapiens

<400>  8406

Met Leu Leu Glu His Arg Lys Gln Gln Asn Glu Ser Ala Glu Asp Glu 
1               5                   10                  15      


Gln Glu Leu Ser Glu Val Phe Met Lys Thr Leu Asn Tyr Thr Ala Arg 
            20                  25                  30          


Phe Ser Arg Phe Lys Asn Arg Glu Thr Ile Ala Ser Val Arg Ser Leu 
        35                  40                  45              


Leu Leu Gln Lys Lys Leu His Lys Phe Glu Leu Ala Cys Leu Ala Asn 
    50                  55                  60                  


Leu Cys Pro Glu Thr Ala Glu Glu Ser Lys Ala Leu Ile Pro Ser Leu 
65                  70                  75                  80  


Glu Gly Arg Phe Glu Asp Glu Glu Leu Gln Gln Ile Leu Asp Asp Ile 
                85                  90                  95      


Gln Thr Lys Arg Ser Phe Gln Tyr 
            100                 


<210>  8407
<211>  1612
<212>  DNA
<213>  Homosapiens

<400>  8407
cgcgcggcgc ggcgcggcga tggcggcggg tggcagcgat ccgcgggctg gcgacgtaga     60

ggaggacgcc tcacagctca tctttcctaa agcttggagg gacggtttga agatgaggag    120

ctgcagcaga ttcttgatga tatccagaca aagcgcagct ttcagtatta atctccaaac    180

atcactgctg ctcggagaaa ccacatcccc aggcataaca ccaccttccc actgtctggg    240

gctgacttgc acagaaattc tgttgaagac agttgagaat tcctttggag aaaacagccc    300

agcttggcgt ggggttaggt tgctgtttca aataactcac aggcccaggt gacatggaat    360

cttggagcag ccttgtgcag tggcagccag tggcttcctg aacgtgcctc tgcgaagtgt    420

gagatgaggg gtcacataac cacactgttg actacctcat tcctggtttt tggcctccac    480

atcatctttt ttcttaatat ttcatgtttt aatttcaggg tgtttatact ttttgaaact    540

agaccagaag atagtagact ttatagagaa agaccagttt tacctagata ctaaaggaag    600

aattaaaccg ctgttagttt gaaatgcttt tttttttttt ttttaaatgg agatagggtc    660

ttaactcttg tccaggctgg aggagtgcag tcgtacagtc atggctcact gaagtcttga    720

ccccgctgcc tcagcctccc aaataactgg ggccacaggt gtgcaccaca actctcagct    780

aatttttaaa attttttata gaggtggggt tttactatgc tgtccagact ggtcttaaac    840

tcctgggctc aagtgatccc cctgccttgg cctcccaaac tggtgagatt acaggcatga    900

gccaccacaa ctggcctgaa attcttaaag gatgggagtg tcgatgacag caccttggca    960

tcgttgtgcc taacctggga gacggaagaa gcacgccatg ggaagtgttt acacttgggg   1020

acaagtgcta agtattgtgg agcccatagc cccttgagat agatggctac tttgcctttc   1080

ttcttgaact gtcttgcaga atgtggattt ggggtaagtg gtcttgaagg attcatttag   1140

tcaccctcaa attaagattt ttacttcatc tttcttgggc ctgcacctcc aagataacaa   1200

agaagaagca atggtcgtgc caaagaggtc cacaaccagg tgtgcactgt tcactgcagc   1260

ccatttgctg tatgaactgt ggttgttgtg tgcccaatga caaggctact aagaaattca   1320

tcatttgaaa cgtagaggcc gcagcagtca gcgatgtttc tgaaatgagc atccttgacg   1380

cctgtgtact tcccaggctg gatgtgaagc tacattacca tgtgagttgt gccattcaca   1440

gcacagtggt gaggaattga gctcatgaag caggcaagga ccgaacacct ccaccccaac   1500

gtagacctgc aggtgctgcc ccatgacctc caccaaagcc catataagga gcggagttgt   1560

taaggactga agaaaaactt ctctggagaa aaataaaatt gcaattctac tt           1612


<210>  8408
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  8408

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Ala Trp Arg Asp Gly Leu Lys Met 
            20                  25                  30          


Arg Ser Cys Ser Arg Phe Leu Met Ile Ser Arg Gln Ser Ala Ala Phe 
        35                  40                  45              


Ser Ile Asn Leu Gln Thr Ser Leu Leu Leu Gly Glu Thr Thr Ser Pro 
    50                  55                  60                  


Gly Ile Thr Pro Pro Ser His Cys Leu Gly Leu Thr Cys Thr Glu Ile 
65                  70                  75                  80  


Leu Leu Lys Thr Val Glu Asn Ser Phe Gly Glu Asn Ser Pro Ala Trp 
                85                  90                  95      


Arg Gly Val Arg Leu Leu Phe Gln Ile Thr His Arg Pro Arg 
            100                 105                 110 


<210>  8409
<211>  1710
<212>  DNA
<213>  Homosapiens

<400>  8409
ggcgcgcggc gcggcgcggc gatggcggcg ggtggcagcg atccgcgggc tggcgacgta     60

gaggaggacg cctcacagct catctttcct aaagcttgct actccagaaa aagcttcata    120

agtttgagtt ggcctgtttg gccaaccttt gcccagagac tgctgaggag tccaaggctc    180

taatcccaag cttggaggga cggtttgaag atgaggagct gcagcagatt cttgatgata    240

tccagacaaa gcgcagcttt cagtattaat ctccaaacat cactgctgct cggagaaacc    300

acatccccag gcataacacc accttcccac tgtctggggc tgacttgcac agaaattctg    360

ttgaagacag ttgagaattc ctttggagaa aacagcccag cttggcgtgg ggttaggttg    420

ctgtttcaaa taactcacag gcccaggtga catggaatct tggagcagcc ttgtgcagtg    480

gcagccagtg gcttcctgaa cgtgcctctg cgaagtgtga gatgaggggt cacataacca    540

cactgttgac tacctcattc ctggtttttg gcctccacat catctttttt cttaatattt    600

catgttttaa tttcagggtg tttatacttt ttgaaactag accagaagat agtagacttt    660

atagagaaag accagtttta cctagatact aaaggaagaa ttaaaccgct gttagtttga    720

aatgcttttt tttttttttt ttaaatggag atagggtctt aactcttgtc caggctggag    780

gagtgcagtc gtacagtcat ggctcactga agtcttgacc ccgctgcctc agcctcccaa    840

ataactgggg ccacaggtgt gcaccacaac tctcagctaa tttttaaaat tttttataga    900

ggtggggttt tactatgctg tccagactgg tcttaaactc ctgggctcaa gtgatccccc    960

tgccttggcc tcccaaactg gtgagattac aggcatgagc caccacaact ggcctgaaat   1020

tcttaaagga tgggagtgtc gatgacagca ccttggcatc gttgtgccta acctgggaga   1080

cggaagaagc acgccatggg aagtgtttac acttggggac aagtgctaag tattgtggag   1140

cccatagccc cttgagatag atggctactt tgcctttctt cttgaactgt cttgcagaat   1200

gtggatttgg ggtaagtggt cttgaaggat tcatttagtc accctcaaat taagattttt   1260

acttcatctt tcttgggcct gcacctccaa gataacaaag aagaagcaat ggtcgtgcca   1320

aagaggtcca caaccaggtg tgcactgttc actgcagccc atttgctgta tgaactgtgg   1380

ttgttgtgtg cccaatgaca aggctactaa gaaattcatc atttgaaacg tagaggccgc   1440

agcagtcagc gatgtttctg aaatgagcat ccttgacgcc tgtgtacttc ccaggctgga   1500

tgtgaagcta cattaccatg tgagttgtgc cattcacagc acagtggtga ggaattgagc   1560

tcatgaagca ggcaaggacc gaacacctcc accccaacgt agacctgcag gtgctgcccc   1620

atgacctcca ccaaagccca tataaggagc ggagttgtta aggactgaag aaaaacttct   1680

ctggagaaaa ataaaattgc aattctactt                                    1710


<210>  8410
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  8410

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Ala Cys Tyr Ser Arg Lys Ser Phe 
            20                  25                  30          


Ile Ser Leu Ser Trp Pro Val Trp Pro Thr Phe Ala Gln Arg Leu Leu 
        35                  40                  45              


Arg Ser Pro Arg Leu 
    50              


<210>  8411
<211>  1801
<212>  DNA
<213>  Homosapiens

<400>  8411
ggtggtggcg cgcggcgcgg cgcggcgatg gcggcgggtg gcagcgatcc gcgggctggc     60

gacgtagagg aggacgcctc acagctcatc tttcctaaag agtttgaaac agctgagaca    120

cttctaaatt cagaagttca tatgcttctg gaacatcgaa agcagcagaa tgagagtgca    180

gaggacgaac aggagctctc agaagtcttc atgaaaacat taaactacac agcccgtttc    240

agtcgtttca aaaacagaga gaccattgcc agtgttcgta gcttggaggg acggtttgaa    300

gatgaggagc tgcagcagat tcttgatgat atccagacaa agcgcagctt tcagtattaa    360

tctccaaaca tcactgctgc tcggagaaac cacatcccca ggcataacac caccttccca    420

ctgtctgggg ctgacttgca cagaaattct gttgaagaca gttgagaatt cctttggaga    480

aaacagccca gcttggcgtg gggttaggtt gctgtttcaa ataactcaca ggcccaggtg    540

acatggaatc ttggagcagc cttgtgcagt ggcagccagt ggcttcctga acgtgcctct    600

gcgaagtgtg agatgagggg tcacataacc acactgttga ctacctcatt cctggttttt    660

ggcctccaca tcatcttttt tcttaatatt tcatgtttta atttcagggt gtttatactt    720

tttgaaacta gaccagaaga tagtagactt tatagagaaa gaccagtttt acctagatac    780

taaaggaaga attaaaccgc tgttagtttg aaatgctttt tttttttttt tttaaatgga    840

gatagggtct taactcttgt ccaggctgga ggagtgcagt cgtacagtca tggctcactg    900

aagtcttgac cccgctgcct cagcctccca aataactggg gccacaggtg tgcaccacaa    960

ctctcagcta atttttaaaa ttttttatag aggtggggtt ttactatgct gtccagactg   1020

gtcttaaact cctgggctca agtgatcccc ctgccttggc ctcccaaact ggtgagatta   1080

caggcatgag ccaccacaac tggcctgaaa ttcttaaagg atgggagtgt cgatgacagc   1140

accttggcat cgttgtgcct aacctgggag acggaagaag cacgccatgg gaagtgttta   1200

cacttgggga caagtgctaa gtattgtgga gcccatagcc ccttgagata gatggctact   1260

ttgcctttct tcttgaactg tcttgcagaa tgtggatttg gggtaagtgg tcttgaagga   1320

ttcatttagt caccctcaaa ttaagatttt tacttcatct ttcttgggcc tgcacctcca   1380

agataacaaa gaagaagcaa tggtcgtgcc aaagaggtcc acaaccaggt gtgcactgtt   1440

cactgcagcc catttgctgt atgaactgtg gttgttgtgt gcccaatgac aaggctacta   1500

agaaattcat catttgaaac gtagaggccg cagcagtcag cgatgtttct gaaatgagca   1560

tccttgacgc ctgtgtactt cccaggctgg atgtgaagct acattaccat gtgagttgtg   1620

ccattcacag cacagtggtg aggaattgag ctcatgaagc aggcaaggac cgaacacctc   1680

caccccaacg tagacctgca ggtgctgccc catgacctcc accaaagccc atataaggag   1740

cggagttgtt aaggactgaa gaaaaacttc tctggagaaa aataaaattg caattctact   1800

t                                                                   1801


<210>  8412
<211>  110
<212>  PRT
<213>  Homosapiens

<400>  8412

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Glu Phe Glu Thr Ala Glu Thr Leu 
            20                  25                  30          


Leu Asn Ser Glu Val His Met Leu Leu Glu His Arg Lys Gln Gln Asn 
        35                  40                  45              


Glu Ser Ala Glu Asp Glu Gln Glu Leu Ser Glu Val Phe Met Lys Thr 
    50                  55                  60                  


Leu Asn Tyr Thr Ala Arg Phe Ser Arg Phe Lys Asn Arg Glu Thr Ile 
65                  70                  75                  80  


Ala Ser Val Arg Ser Leu Glu Gly Arg Phe Glu Asp Glu Glu Leu Gln 
                85                  90                  95      


Gln Ile Leu Asp Asp Ile Gln Thr Lys Arg Ser Phe Gln Tyr 
            100                 105                 110 


<210>  8413
<211>  1918
<212>  DNA
<213>  Homosapiens

<400>  8413
gcttctgctt ccggcggcgc tggtggtggc gcgcggcgcg gcgcggcgat ggcggcgggt     60

ggcagcgatc cgcgggctgg cgacgtagag gaggacgcct cacagctcat ctttcctaaa    120

gagtttgaaa cagctgagac acttctaaat tcagaagttc atatgcttct ggaacatcga    180

aagcagcaga atgagagtgc agaggacgaa caggagctct cagaagtctt catgaaaaca    240

ttaaactaca cagcccgttt cagtcgtttc aaaaacagag agaccattgc cagtgttcgt    300

agcttgctac tccagaaaaa gcttcataag tttgagttgg cctgtttggc caacctttgc    360

ccagagactg ctgaggagtc caaggctcta atcccaagct tggagggacg gtttgaagat    420

gaggagctgc agcagattct tgatgatatc cagacaaagc gcagctttca gtattaatct    480

ccaaacatca ctgctgctcg gagaaaccac atccccaggc ataacaccac cttcccactg    540

tctggggctg acttgcacag aaattctgtt gaagacagtt gagaattcct ttggagaaaa    600

cagcccagct tggcgtgggg ttaggttgct gtttcaaata actcacaggc ccaggtgaca    660

tggaatcttg gagcagcctt gtgcagtggc agccagtggc ttcctgaacg tgcctctgcg    720

aagtgtgaga tgaggggtca cataaccaca ctgttgacta cctcattcct ggtttttggc    780

ctccacatca tcttttttct taatatttca tgttttaatt tcagggtgtt tatacttttt    840

gaaactagac cagaagatag tagactttat agagaaagac cagttttacc tagatactaa    900

aggaagaatt aaaccgctgt tagtttgaaa tgcttttttt tttttttttt aaatggagat    960

agggtcttaa ctcttgtcca ggctggagga gtgcagtcgt acagtcatgg ctcactgaag   1020

tcttgacccc gctgcctcag cctcccaaat aactggggcc acaggtgtgc accacaactc   1080

tcagctaatt tttaaaattt tttatagagg tggggtttta ctatgctgtc cagactggtc   1140

ttaaactcct gggctcaagt gatccccctg ccttggcctc ccaaactggt gagattacag   1200

gcatgagcca ccacaactgg cctgaaattc ttaaaggatg ggagtgtcga tgacagcacc   1260

ttggcatcgt tgtgcctaac ctgggagacg gaagaagcac gccatgggaa gtgtttacac   1320

ttggggacaa gtgctaagta ttgtggagcc catagcccct tgagatagat ggctactttg   1380

cctttcttct tgaactgtct tgcagaatgt ggatttgggg taagtggtct tgaaggattc   1440

atttagtcac cctcaaatta agatttttac ttcatctttc ttgggcctgc acctccaaga   1500

taacaaagaa gaagcaatgg tcgtgccaaa gaggtccaca accaggtgtg cactgttcac   1560

tgcagcccat ttgctgtatg aactgtggtt gttgtgtgcc caatgacaag gctactaaga   1620

aattcatcat ttgaaacgta gaggccgcag cagtcagcga tgtttctgaa atgagcatcc   1680

ttgacgcctg tgtacttccc aggctggatg tgaagctaca ttaccatgtg agttgtgcca   1740

ttcacagcac agtggtgagg aattgagctc atgaagcagg caaggaccga acacctccac   1800

cccaacgtag acctgcaggt gctgccccat gacctccacc aaagcccata taaggagcgg   1860

agttgttaag gactgaagaa aaacttctct ggagaaaaat aaaattgcaa ttctactt     1918


<210>  8414
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  8414

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Glu Phe Glu Thr Ala Glu Thr Leu 
            20                  25                  30          


Leu Asn Ser Glu Val His Met Leu Leu Glu His Arg Lys Gln Gln Asn 
        35                  40                  45              


Glu Ser Ala Glu Asp Glu Gln Glu Leu Ser Glu Val Phe Met Lys Thr 
    50                  55                  60                  


Leu Asn Tyr Thr Ala Arg Phe Ser Arg Phe Lys Asn Arg Glu Thr Ile 
65                  70                  75                  80  


Ala Ser Val Arg Ser Leu Leu Leu Gln Lys Lys Leu His Lys Phe Glu 
                85                  90                  95      


Leu Ala Cys Leu Ala Asn Leu Cys Pro Glu Thr Ala Glu Glu Ser Lys 
            100                 105                 110         


Ala Leu Ile Pro Ser Leu Glu Gly Arg Phe Glu Asp Glu Glu Leu Gln 
        115                 120                 125             


Gln Ile Leu Asp Asp Ile Gln Thr Lys Arg Ser Phe Gln Tyr 
    130                 135                 140         


<210>  8415
<211>  759
<212>  DNA
<213>  Homosapiens

<400>  8415
gctggtggtg gcgcgcggcg cggcgcggcg atggcggcgg gtggcagcga tccgcgggct     60

ggcgacgtag aggaggacgc ctcacagctc atctttccta aagagtttga aacagctgag    120

acacttctaa attcagaagt tcatatgctt ctggaacatc gaaagcagca gaatgagagt    180

gcagaggacg aacaggagct ctcagaagtc ttcatgaaaa cattaaacta cacagcccgt    240

ttcagtcgtt tcaaaaacag agagaccatt gccagtgttc gtagagacaa ggtctcactg    300

tgttgcccag gctgaagacg tcttgaactc ctggactcaa gtgatcctcc tgccttggcc    360

tcccaaagtg ctaggattac aggcatgagc tgctaagcct ggcctcttct accttttttt    420

tgttttgttt cgttttgttt tgagacagtc tcacttcatc acccagattg gagtgtagtg    480

gtgcggtctt ggctcactgc aacctccacc tcccaggtta aagcagttct catgcctcag    540

ccttccaaat agctgggact acagacacac accaccacac ccggctaatt tttttagttt    600

tttgtttttt tggttttgtt tgtttgtttg tttgtctgtt ttgagacgga gtctagttct    660

gtcacccagg ctggagtgca gtggcgtgat cttggctcac tgcagcctcc gcctcccggg    720

ttcaagcaat tctcctgcct cagcctcccg agtagctgg                           759


<210>  8416
<211>  94
<212>  PRT
<213>  Homosapiens

<400>  8416

Met Ala Ala Gly Gly Ser Asp Pro Arg Ala Gly Asp Val Glu Glu Asp 
1               5                   10                  15      


Ala Ser Gln Leu Ile Phe Pro Lys Glu Phe Glu Thr Ala Glu Thr Leu 
            20                  25                  30          


Leu Asn Ser Glu Val His Met Leu Leu Glu His Arg Lys Gln Gln Asn 
        35                  40                  45              


Glu Ser Ala Glu Asp Glu Gln Glu Leu Ser Glu Val Phe Met Lys Thr 
    50                  55                  60                  


Leu Asn Tyr Thr Ala Arg Phe Ser Arg Phe Lys Asn Arg Glu Thr Ile 
65                  70                  75                  80  


Ala Ser Val Arg Arg Asp Lys Val Ser Leu Cys Cys Pro Gly 
                85                  90                  


<210>  8417
<211>  4650
<212>  DNA
<213>  Homosapiens

<400>  8417
gttggtgaag agatcaggaa gagatttctt cgagactaag gatggatgac ccttagcaac     60

agtgaccgtc tcctcccggc atagcaagat ggcctgccct caggtacagg aagaaggaat    120

ggaatcggaa ggaagaaaat tcattccaga gacaaaatag ctcccctcct ctgttgtagc    180

tgttcctctg gcaatacaaa ctttctgctt tcaggttctg cagcattcca gaccttgagc    240

actgaatcag gatgggaaaa agacgttgtg ttcctccact cgagcccaag ttggcagcag    300

gctgttgtgg ggtcaagaag cccaaattat ctggaagtgg aacgcacagt cacgggaatc    360

agtccacaac tgtccccggc tctagttcag gacctcttca aaaccaccag catgtggaca    420

gcagcagtgg acgggagaat gtgtcagact taactctggg acctggaaac tctcccatca    480

cacgaatgaa tcccgcatcg ggagcgctga gccctcttcc ccggcctaat ggaactgcca    540

acaccactaa gaatctggtg gtgactgcag agatgtgctg ctactgcttc gacgtactct    600

actgtcacct ctatggcttc ccacagccac gacttcctag attcaccaat gacccctatc    660

cgctctttgt gacgtggaag acagggcggg acaagcggct tcgtggctgc attgggacct    720

tctcagccat gaatcttcat tcaggactca gggaatacac gttaaccagt gcacttaagg    780

acagccgatt tccccccctg acccgagagg agctgcctaa acttttctgc tctgtctccc    840

tccttactaa ctttgaggat gccagtgatt acctggactg ggaggtaggg gtccatggga    900

ttcgaattga attcattaat gaaaaaggtg tcaaacgcac agccacatat ttacctgagg    960

ttgctaagga acaagactgg gatcagatcc agacaataga ctccttgctc aggaaaggtg   1020

gctttaaagc tccaattacc agtgaattca gaaaaacgat caaactcacc aggtaccgaa   1080

gtgagaaggt gacaatcagt tacgcagagt atattgcttc ccgacagcac tgtttccaga   1140

acggcactct tcatgccccg cccctctaca atcattactc ctgacacacg gctgcatgac   1200

cagtcccacc cccccgtggc caccaatggc tatgacatca ttggagcaga tgcctcctct   1260

tcctggtcca gttacttcta ttactgcacc attttatgat gctagcttcc gttgccaagt   1320

ctgcctcccg ctgactgagg gagggtaggg ttaccttgaa cgaaacagaa cttgaggggc   1380

ccaagcctta tctcagcctt tcctcaatat ggggttccgt tggattgggg ctcctccatg   1440

actagtggga attactgtgg gttcagaaga cccttgtctg gtatttgcca catggggtat   1500

tggccacacg ctggaagctg aaattgatga tccctgaagg ttgaacccac acacacccct   1560

gcagcctccc cagatgaagt aggtgtattc ccctggcagt ctgggcaacg gagaccaaga   1620

aacattttta ggttgtttta aattcctttt tttaaacttc cagtttattg cgtaccaaga   1680

gttgattaca acctccatgc ttcataagcg gacgccacgt tagggttgga cgtgggcacc   1740

acgagtcctt tgaggctcct ggacagagac ccacatcaag atcggaagcc ctttgggtgg   1800

cgttgcagat ctcattgctc agtaggccgt gaagattttc atcctcatcc cactctcagt   1860

tggattttct ggcactcttc ctgcattgag tctcctgatt actgaacaga gctccgtcat   1920

gtagcctgct gaggaatgga atggaatgga gatgcccaca ggaggtcctg atgtcatcac   1980

tgcacgcagg tgtgagagga gagacctctt ctgcaccgcc tggctacctc actcctctgc   2040

tggtagcagt gcctatagct ggacctaagt tctcagaagc gtagatgtgc aaacaagcga   2100

ttgagttggg ctttaggagg acacatcata ggagagaatc cagggtctgt aagctggttt   2160

tcttttcagg tgacatcctg aggggcctgt aagcagggga gctccttttt ctagtttgcc   2220

tgtagaggtg ggaagactgt tggtgtttct gtcctttaca ggacattagg aaacagttgt   2280

gtaattacac aaggtggacc tttatcttgc ctgacatgct gggaatcttc accccaccag   2340

ggcaaatttc caaatagctc attttattct aggtctttca aactttcatg tgacatattt   2400

ccctttccca ttgttgctga tttccaaatc gctgtcagca attttttcct ctctccttgc   2460

ctattcttca ctcatttggt ggcaaagttc atagaactag gggacttgga agatgctttg   2520

aaaatattgt tacaaaggca ctgctaaaat gattcacagg gagagtggcc agttggaaga   2580

aggatcctaa ggatgtgaca ctggttttca acaacatgct tagagaactc atgaagtgga   2640

ttgggtgtca acccagtgaa catgttttta tttaatttat tttttgaagt ttatgtggtg   2700

atggtgtggc tttccgaaat gggcaaatat tcagaagatc ttttgcattt tcttctgtca   2760

ggaatgggga aggggagtgg gggcacaatc tgagaaagga cacctgtgct gttctaggca   2820

tcgctggcaa gtttgtggga agggatgggc aagggtgagt gggtttgctc cacaccgtcc   2880

tgtgctgctc gagaggacct gggacgtgcg agggaaacgt gggtgacggt gcctaggctg   2940

cggcccttca ctgctgtgct gggttcctgc agcctgctac gtttcccttg gcaatgtaaa   3000

tgaagatgga ggggtcgttt cgtgatttcc tgctgctgag aataaatgtc ttgttaaaaa   3060

cgtggcaacg gttactctta ggtgccatgg atcgatgtca gggtggtcag ctctggacta   3120

agccacccac ctccaatttg tacaacagta ttgatacata gggctacact cattactgtt   3180

caagtgttct atgttaagag ttgtgtttaa tttctaaaga ttaaaaaaag caaaaaaatt   3240

ggtgctaaac cttcacccct gagcacgctc agtgagactg gtcatgcaag catttacagt   3300

gccatgctcc tcaagccgat tttttcttgt agaaatgttg ccctatttgt cttctccaat   3360

gtatggtatg ttattttatt ttattatttt attttatttt attttatttt atcgaggggg   3420

ggtacgatac ctgccattta agaaaatgaa tagaaaattt taaaacccga gaaatgggga   3480

aaaaaaaatc agtgcacaag aattgggctg gttaggccca gcaccacact gaagtgggct   3540

cagtggtttt tggagtgaag aagccttact ccctgcacat tccctcatgc tcccacacaa   3600

gtccagcaat ggaaatgctt gggttcctct tgctttgtca ggggactcag gagtcgacca   3660

agggaaacca tttggccccg tgaggaatgg gcattgtcag tatccgtcct gaacggggcc   3720

tagtcaggaa gcggtctaga agtgtacggt cacggtcgcc tcatgaaagt gtgtagcagg   3780

tggctctcag gaaaaatacc aagtctggat catccatgtg gcagctttgc atagggagag   3840

gatagctccg aactggaact gaactgcctt ctctgcacgc ttgaccaaag cagtgatgag   3900

ggcggccagt acctgcggtg tgcgtggtag gtttaaagaa aagggaatgt tttctgctga   3960

gtgtttcctt tgtccttggg ctgctcgagc tggacagtag gtaaccactg ttttcaagga   4020

ccagcccaat ttctctggct tggttcggag ttcgtttcat ccctagctgt gagtgccttt   4080

tggtctggaa agttggcttg tctcataata cccacagcta ggacattctc tctgtaatta   4140

tgaattgtcc ttgttttaca ttaaaagaga atgtctttga tcactagagt ctgtcggtgt   4200

tggattattt ccactgtgag attcttaaaa cttttttgct tcataataat aaaacaactc   4260

atgttagaga ccctttcaac atgaaaggtt tgtagttgag acattacata tattttattg   4320

tttataataa aaatcatcta tacaaaagaa gtcctgggtg ttaatatttt gcacaagatc   4380

tgttttccat gatgtgttga catctacaat ttcactaact gttgacgtta ttttctattg   4440

agattctgga gcctagggag ctatgtgttc tttttgttca tttcgttctt acttccctga   4500

agcaagagac tatatggcct tcagtgcaaa gacttcagac caattctttg tattacactt   4560

ggttgcctct tggctatata acttctgagt gcaaatcatt gaacacttta acgaagtatt   4620

gtagagaata aatcataatg gataaaaatc                                    4650


<210>  8418
<211>  310
<212>  PRT
<213>  Homosapiens

<400>  8418

Met Gly Lys Arg Arg Cys Val Pro Pro Leu Glu Pro Lys Leu Ala Ala 
1               5                   10                  15      


Gly Cys Cys Gly Val Lys Lys Pro Lys Leu Ser Gly Ser Gly Thr His 
            20                  25                  30          


Ser His Gly Asn Gln Ser Thr Thr Val Pro Gly Ser Ser Ser Gly Pro 
        35                  40                  45              


Leu Gln Asn His Gln His Val Asp Ser Ser Ser Gly Arg Glu Asn Val 
    50                  55                  60                  


Ser Asp Leu Thr Leu Gly Pro Gly Asn Ser Pro Ile Thr Arg Met Asn 
65                  70                  75                  80  


Pro Ala Ser Gly Ala Leu Ser Pro Leu Pro Arg Pro Asn Gly Thr Ala 
                85                  90                  95      


Asn Thr Thr Lys Asn Leu Val Val Thr Ala Glu Met Cys Cys Tyr Cys 
            100                 105                 110         


Phe Asp Val Leu Tyr Cys His Leu Tyr Gly Phe Pro Gln Pro Arg Leu 
        115                 120                 125             


Pro Arg Phe Thr Asn Asp Pro Tyr Pro Leu Phe Val Thr Trp Lys Thr 
    130                 135                 140                 


Gly Arg Asp Lys Arg Leu Arg Gly Cys Ile Gly Thr Phe Ser Ala Met 
145                 150                 155                 160 


Asn Leu His Ser Gly Leu Arg Glu Tyr Thr Leu Thr Ser Ala Leu Lys 
                165                 170                 175     


Asp Ser Arg Phe Pro Pro Leu Thr Arg Glu Glu Leu Pro Lys Leu Phe 
            180                 185                 190         


Cys Ser Val Ser Leu Leu Thr Asn Phe Glu Asp Ala Ser Asp Tyr Leu 
        195                 200                 205             


Asp Trp Glu Val Gly Val His Gly Ile Arg Ile Glu Phe Ile Asn Glu 
    210                 215                 220                 


Lys Gly Val Lys Arg Thr Ala Thr Tyr Leu Pro Glu Val Ala Lys Glu 
225                 230                 235                 240 


Gln Asp Trp Asp Gln Ile Gln Thr Ile Asp Ser Leu Leu Arg Lys Gly 
                245                 250                 255     


Gly Phe Lys Ala Pro Ile Thr Ser Glu Phe Arg Lys Thr Ile Lys Leu 
            260                 265                 270         


Thr Arg Tyr Arg Ser Glu Lys Val Thr Ile Ser Tyr Ala Glu Tyr Ile 
        275                 280                 285             


Ala Ser Arg Gln His Cys Phe Gln Asn Gly Thr Leu His Ala Pro Pro 
    290                 295                 300                 


Leu Tyr Asn His Tyr Ser 
305                 310 


<210>  8419
<211>  513
<212>  DNA
<213>  Homosapiens

<400>  8419
aggacagccg atttcccccc ctgacccgag aggagctgcc taaacttttc tgctctgtct     60

ccctccttac taactttgag gatgccagtg attacctgga ctgggaggta ggggtccatg    120

ggattcgaat tgaattcatt aatgaaaaag gtgtcaaacg cacagccaca tatttacctg    180

aggttgctaa ggaacaaggt gagttggatg aatgggattt taatgacaag tatcattcac    240

agtggtgcca gttaaagggc aagaaagtga agtgtgtcat cttgcagccc aactgcagct    300

gagaatgagg gcctttctgc ctcttaatac ctgtcaaatt cctatagaac caagggtaaa    360

cttccaaaaa ggtttaggag ctgggaaaag caaaagggta aatcgttcac ttactcgcct    420

gatatttcaa acacttcttt tcaatgaata gttttatttc ttagcccctt aaactacagt    480

ggcaattgta gcaaaatacc accaatcaac ctg                                 513


<210>  8420
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  8420

Met Arg Ala Phe Leu Pro Leu Asn Thr Cys Gln Ile Pro Ile Glu Pro 
1               5                   10                  15      


Arg Val Asn Phe Gln Lys Gly Leu Gly Ala Gly Lys Ser Lys Arg Val 
            20                  25                  30          


Asn Arg Ser Leu Thr Arg Leu Ile Phe Gln Thr Leu Leu Phe Asn Glu 
        35                  40                  45              


<210>  8421
<211>  301
<212>  DNA
<213>  Homosapiens

<400>  8421
agaccattta aaagctctcc gccggtttca gaacacaaat aaatttccca atcctctgca     60

aagacagaac tgaagaatta ctggacagca cgccagaggc agggacctga gggcaggcca    120

tcttgctatg ccgggaggag acggtcactg ttgctaaggg tcatccatcc ttagtctcga    180

agaaatctct tcctgatctc ttcaccaact ctccccacta ctagagaatt gagctactcc    240

caaagatgag gccttgatgt gcagacgcga tggggcaacg atgagaccga ataaacaatt    300

g                                                                    301


<210>  8422
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  8422

Ile Ser Gln Ser Ser Ala Lys Thr Glu Leu Lys Asn Tyr Trp Thr Ala 
1               5                   10                  15      


Arg Gln Arg Gln Gly Pro Glu Gly Arg Pro Ser Cys Tyr Ala Gly Arg 
            20                  25                  30          


Arg Arg Ser Leu Leu Leu Arg Val Ile His Pro 
        35                  40              


<210>  8423
<211>  4066
<212>  DNA
<213>  Homosapiens

<400>  8423
gaggactgcg agcacagcgg cggccgggtg gcgggggtga gtggggccag cggggctgga     60

cagcagcggg ccccgggcgc cgccgccgcg atccctcccc gcgcccgccg agcacatcgc    120

cgccgccgag atgggccctc cgcggcaccc ccaggccggc gagatagaag cgggcggtgc    180

gggcggcggg cggcggctac aggtggaaat gagttctcaa cagtttcctc ggttaggagc    240

cccttctacc gggctgagcc aggccccttc tcagattgca aacagtggtt ctgctggatt    300

gataaaccca gctgctacag tcaatgatga atctggtcga gattctgaag tcagtgccag    360

ggagcacatg agttccagca gctccctcca gtcccgggag gagaagcaag agcctgttgt    420

ggtaaggccc tatccacagg tgcagatgtt gtcgacacac catgctgtcg catcagccac    480

acctgttgca gtgacagccc cgccagcaca cctgacgcca gcagtgccac tttcattttc    540

ggagggactt atgaagccgc ccccgaagcc caccatgcct agccgtccca ttgctcctgc    600

tccaccttct accctgtcac ttccccccaa ggttccaggg caggttaccg ttaccatgga    660

gagtagcatc cctcaagctt cagccattcc tgtggcaaca atcagtggac aacagggcca    720

tcccagtaac ctgcatcaca tcatgactac aaatgtgcaa atgtctatca tccgcagcaa    780

tgctcctggg ccccctcttc acattggagc ttctcattta cctcgaggtg cagctgctgc    840

tgctgtgatg tccagttcta aagtaaccac agtcctgagg ccgacctcac agctgccaaa    900

tgctgctact gctcagccag cagtacagca catcattcac caaccaatcc agtctcggcc    960

acctgtgacc acctccaatg ccatccctcc tgctgtggta gcaactgtct cagccaccag   1020

agctcagtct ccagtcatca ctacgacagc ggcgcatgct actgattcag cacttagtag   1080

gccaaccttg tctatccagc atcctccatc tgcagcaatc agtattcagc gtcctgccca   1140

gtcacgagat gtcacaacaa gaatcacact accatctcac cctgcattag ggacgccaaa   1200

acagcagctt catacaatgg ctcagaaaac aatcttcagt actggcacgc cagtggctgc   1260

agccacagta gcacctattt tggcaaccaa caccattcct tcagcgacca cagctggatc   1320

tgtgtcacac acgcaagctc ccacaagtac cattgttacc atgacagtac cctcccattc   1380

ctcccatgct actgctgtga ccacctcaaa catcccagtc gccaaggtgg tgccccagca   1440

gatcacgcac acttctcctc ggatccagcc agactaccct gccgagagga gtagcctgat   1500

tcccatctcc ggacatcggg cctctcccaa tcctgtggcc atggaaaccc gaagtgacaa   1560

cagaccgtct gttcccgttc agttccaata ttttttgcca acttaccccc cttctgcata   1620

cccactggcg gcacatacct acaccccaat caccagttcc gtgtccacta tccgacagta   1680

tccagtttca gctcaggctc caaactctgc catcacagct cagactggtg ttggggtagc   1740

gtctaccgtc cacctaaacc ccatgcagtt gatgacagtg gatgcatcgc atgctcgaca   1800

tattcaaggg atccagccag cacccatcag tacccagggt atccagccgg cccccattgg   1860

gaccccaggg atacagcctg caccacttgg cacacaggga attcactcag caaccccaat   1920

caacacacaa gggcttcagc ctgcacctat gggtactcag cagcctcagc ctgaaggaaa   1980

gacttcagca gtggtgttgg cagatggagc cacaattgtg gccaacccta ttagcaatcc   2040

attcagtgct gctccagcag caacaaccgt ggtgcagacc cacagccaga gtgctagcac   2100

caacgctccc gcccagggct catcgccacg gccaagcata ctccggaaga aacctgccac   2160

agatggtgcc aaacccaagt ctgaaatcca cgtgtctatg gccactccgg tcactgtgtc   2220

catggagact gtatccaatc aaaataatga tcagcctacc attgccgtcc ctccaactgc   2280

ccagcagccc ccaccgacca ttccaactat gattgcagca gccagtcccc cgtcacaacc   2340

agccgttgcc ctttcaacca ttcctggagc ggtccccatc actccaccca tcaccaccat   2400

tgcagctgca ccacctccat cagtcactgt gggtggcagt ctttcctccg tcttgggccc   2460

tcccgttcct gaaattaaag tgaaagaaga agtagaacca atggatatca tgaggccagt   2520

ttctgcagtt cctccactgg ctaccaacac tgtgtctcca tctcttgcat tgctggcaaa   2580

caacttgtcc atgcctacaa gtgacctacc acctggtgcc tccccaagga aaaagcctcg   2640

aaagcaacag catgtgatct caacagaaga aggtgacatg atggagacaa acagcactga   2700

tgatgagaag tccactgcca agagtcttct ggtgaaggct gagaagcgca agtctcctcc   2760

caaggagtat attgatgagg aaggtgtgag atatgtccca gtgcgtccaa gaccccccat   2820

tactttgctt cgtcactatc ggaacccctg gaaagctgct taccaccact ttcagaggta   2880

cagtgacgtc cgggtcaaag aggagaagaa agctatgctg caggaaatag ctaatcagaa   2940

aggagtatcc tgtcgtgctc aaggctggaa agtccacctc tgtgctgccc agttactaca   3000

gctgacgaat ctagaacatg atgtctatga aagacttact aacctgcagg aagggattat   3060

cccaaagaaa aaagcagcaa cagatgatga tctccaccga ataaacgaac tgatacaggg   3120

aaatatgcag aggtgtaaac ttgtgatgga tcaaatcagt gaagccagag actccatgct   3180

taaggtttta gatcataaag accgtgtcct gaagctgctt aacaagaacg ggactgtcaa   3240

aaaagtgtcc aaattgaagc gaaaggaaaa agtctagacc cagaacaatc aggagattgg   3300

aagcaaattt atgaagaatg atggtggggg tggggggagg gttttggttt tttccaaagt   3360

ggaacattga aataaaggaa gtgttcctta gttcccgtgt gaaagcagag gaacccatga   3420

catccaaggg cgtgaaagga tcagagctga ctggacatag tgagctgcct tcttgcgttc   3480

gggtgcaccc ctgttaaacc tgatctgtgt cataagtgac tccggatgca tcagtgtcca   3540

ccagttggaa gcaatgacaa ggatggctgg ctggtgtttt tcagccttcc ggtttataga   3600

ctgtatttat ctagtggatt cctgcaggcc ccatactgag cctggactga aagtatccac   3660

tcggaccatc tgttatctct ctacactgaa aataaaacct cttccaccca ccccattcgg   3720

ttcttctgcc tgaccttcaa atgcccatgt tggcctttta cagcagtgcc acggcaccaa   3780

gcgagctgcc acatctcaca ctctaaaggg tttgaactat tagttcttgt cattttttaa   3840

aaaaaaccat tcccaagtga aattgttata tcgtctgtct tgcgtgtgtc agaactgggt   3900

ttttgtggag gttcagagca ggcaacacca taagttgctc tcagatcctt gttctgaagt   3960

acattcttgg ttatctgtac ttctgtagct ggtgtgatgc tgttaattgt atgtaccaca   4020

catctccaga cgttaataaa ggactcaaag aggtttttgt acttgc                  4066


<210>  8424
<211>  1048
<212>  PRT
<213>  Homosapiens

<400>  8424

Met Gly Pro Pro Arg His Pro Gln Ala Gly Glu Ile Glu Ala Gly Gly 
1               5                   10                  15      


Ala Gly Gly Gly Arg Arg Leu Gln Val Glu Met Ser Ser Gln Gln Phe 
            20                  25                  30          


Pro Arg Leu Gly Ala Pro Ser Thr Gly Leu Ser Gln Ala Pro Ser Gln 
        35                  40                  45              


Ile Ala Asn Ser Gly Ser Ala Gly Leu Ile Asn Pro Ala Ala Thr Val 
    50                  55                  60                  


Asn Asp Glu Ser Gly Arg Asp Ser Glu Val Ser Ala Arg Glu His Met 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Leu Gln Ser Arg Glu Glu Lys Gln Glu Pro Val 
                85                  90                  95      


Val Val Arg Pro Tyr Pro Gln Val Gln Met Leu Ser Thr His His Ala 
            100                 105                 110         


Val Ala Ser Ala Thr Pro Val Ala Val Thr Ala Pro Pro Ala His Leu 
        115                 120                 125             


Thr Pro Ala Val Pro Leu Ser Phe Ser Glu Gly Leu Met Lys Pro Pro 
    130                 135                 140                 


Pro Lys Pro Thr Met Pro Ser Arg Pro Ile Ala Pro Ala Pro Pro Ser 
145                 150                 155                 160 


Thr Leu Ser Leu Pro Pro Lys Val Pro Gly Gln Val Thr Val Thr Met 
                165                 170                 175     


Glu Ser Ser Ile Pro Gln Ala Ser Ala Ile Pro Val Ala Thr Ile Ser 
            180                 185                 190         


Gly Gln Gln Gly His Pro Ser Asn Leu His His Ile Met Thr Thr Asn 
        195                 200                 205             


Val Gln Met Ser Ile Ile Arg Ser Asn Ala Pro Gly Pro Pro Leu His 
    210                 215                 220                 


Ile Gly Ala Ser His Leu Pro Arg Gly Ala Ala Ala Ala Ala Val Met 
225                 230                 235                 240 


Ser Ser Ser Lys Val Thr Thr Val Leu Arg Pro Thr Ser Gln Leu Pro 
                245                 250                 255     


Asn Ala Ala Thr Ala Gln Pro Ala Val Gln His Ile Ile His Gln Pro 
            260                 265                 270         


Ile Gln Ser Arg Pro Pro Val Thr Thr Ser Asn Ala Ile Pro Pro Ala 
        275                 280                 285             


Val Val Ala Thr Val Ser Ala Thr Arg Ala Gln Ser Pro Val Ile Thr 
    290                 295                 300                 


Thr Thr Ala Ala His Ala Thr Asp Ser Ala Leu Ser Arg Pro Thr Leu 
305                 310                 315                 320 


Ser Ile Gln His Pro Pro Ser Ala Ala Ile Ser Ile Gln Arg Pro Ala 
                325                 330                 335     


Gln Ser Arg Asp Val Thr Thr Arg Ile Thr Leu Pro Ser His Pro Ala 
            340                 345                 350         


Leu Gly Thr Pro Lys Gln Gln Leu His Thr Met Ala Gln Lys Thr Ile 
        355                 360                 365             


Phe Ser Thr Gly Thr Pro Val Ala Ala Ala Thr Val Ala Pro Ile Leu 
    370                 375                 380                 


Ala Thr Asn Thr Ile Pro Ser Ala Thr Thr Ala Gly Ser Val Ser His 
385                 390                 395                 400 


Thr Gln Ala Pro Thr Ser Thr Ile Val Thr Met Thr Val Pro Ser His 
                405                 410                 415     


Ser Ser His Ala Thr Ala Val Thr Thr Ser Asn Ile Pro Val Ala Lys 
            420                 425                 430         


Val Val Pro Gln Gln Ile Thr His Thr Ser Pro Arg Ile Gln Pro Asp 
        435                 440                 445             


Tyr Pro Ala Glu Arg Ser Ser Leu Ile Pro Ile Ser Gly His Arg Ala 
    450                 455                 460                 


Ser Pro Asn Pro Val Ala Met Glu Thr Arg Ser Asp Asn Arg Pro Ser 
465                 470                 475                 480 


Val Pro Val Gln Phe Gln Tyr Phe Leu Pro Thr Tyr Pro Pro Ser Ala 
                485                 490                 495     


Tyr Pro Leu Ala Ala His Thr Tyr Thr Pro Ile Thr Ser Ser Val Ser 
            500                 505                 510         


Thr Ile Arg Gln Tyr Pro Val Ser Ala Gln Ala Pro Asn Ser Ala Ile 
        515                 520                 525             


Thr Ala Gln Thr Gly Val Gly Val Ala Ser Thr Val His Leu Asn Pro 
    530                 535                 540                 


Met Gln Leu Met Thr Val Asp Ala Ser His Ala Arg His Ile Gln Gly 
545                 550                 555                 560 


Ile Gln Pro Ala Pro Ile Ser Thr Gln Gly Ile Gln Pro Ala Pro Ile 
                565                 570                 575     


Gly Thr Pro Gly Ile Gln Pro Ala Pro Leu Gly Thr Gln Gly Ile His 
            580                 585                 590         


Ser Ala Thr Pro Ile Asn Thr Gln Gly Leu Gln Pro Ala Pro Met Gly 
        595                 600                 605             


Thr Gln Gln Pro Gln Pro Glu Gly Lys Thr Ser Ala Val Val Leu Ala 
    610                 615                 620                 


Asp Gly Ala Thr Ile Val Ala Asn Pro Ile Ser Asn Pro Phe Ser Ala 
625                 630                 635                 640 


Ala Pro Ala Ala Thr Thr Val Val Gln Thr His Ser Gln Ser Ala Ser 
                645                 650                 655     


Thr Asn Ala Pro Ala Gln Gly Ser Ser Pro Arg Pro Ser Ile Leu Arg 
            660                 665                 670         


Lys Lys Pro Ala Thr Asp Gly Ala Lys Pro Lys Ser Glu Ile His Val 
        675                 680                 685             


Ser Met Ala Thr Pro Val Thr Val Ser Met Glu Thr Val Ser Asn Gln 
    690                 695                 700                 


Asn Asn Asp Gln Pro Thr Ile Ala Val Pro Pro Thr Ala Gln Gln Pro 
705                 710                 715                 720 


Pro Pro Thr Ile Pro Thr Met Ile Ala Ala Ala Ser Pro Pro Ser Gln 
                725                 730                 735     


Pro Ala Val Ala Leu Ser Thr Ile Pro Gly Ala Val Pro Ile Thr Pro 
            740                 745                 750         


Pro Ile Thr Thr Ile Ala Ala Ala Pro Pro Pro Ser Val Thr Val Gly 
        755                 760                 765             


Gly Ser Leu Ser Ser Val Leu Gly Pro Pro Val Pro Glu Ile Lys Val 
    770                 775                 780                 


Lys Glu Glu Val Glu Pro Met Asp Ile Met Arg Pro Val Ser Ala Val 
785                 790                 795                 800 


Pro Pro Leu Ala Thr Asn Thr Val Ser Pro Ser Leu Ala Leu Leu Ala 
                805                 810                 815     


Asn Asn Leu Ser Met Pro Thr Ser Asp Leu Pro Pro Gly Ala Ser Pro 
            820                 825                 830         


Arg Lys Lys Pro Arg Lys Gln Gln His Val Ile Ser Thr Glu Glu Gly 
        835                 840                 845             


Asp Met Met Glu Thr Asn Ser Thr Asp Asp Glu Lys Ser Thr Ala Lys 
    850                 855                 860                 


Ser Leu Leu Val Lys Ala Glu Lys Arg Lys Ser Pro Pro Lys Glu Tyr 
865                 870                 875                 880 


Ile Asp Glu Glu Gly Val Arg Tyr Val Pro Val Arg Pro Arg Pro Pro 
                885                 890                 895     


Ile Thr Leu Leu Arg His Tyr Arg Asn Pro Trp Lys Ala Ala Tyr His 
            900                 905                 910         


His Phe Gln Arg Tyr Ser Asp Val Arg Val Lys Glu Glu Lys Lys Ala 
        915                 920                 925             


Met Leu Gln Glu Ile Ala Asn Gln Lys Gly Val Ser Cys Arg Ala Gln 
    930                 935                 940                 


Gly Trp Lys Val His Leu Cys Ala Ala Gln Leu Leu Gln Leu Thr Asn 
945                 950                 955                 960 


Leu Glu His Asp Val Tyr Glu Arg Leu Thr Asn Leu Gln Glu Gly Ile 
                965                 970                 975     


Ile Pro Lys Lys Lys Ala Ala Thr Asp Asp Asp Leu His Arg Ile Asn 
            980                 985                 990         


Glu Leu Ile Gln Gly Asn Met Gln  Arg Cys Lys Leu Val  Met Asp Gln 
        995                 1000                 1005             


Ile Ser  Glu Ala Arg Asp Ser  Met Leu Lys Val Leu  Asp His Lys 
    1010                 1015                 1020             


Asp Arg  Val Leu Lys Leu Leu  Asn Lys Asn Gly Thr  Val Lys Lys 
    1025                 1030                 1035             


Val Ser  Lys Leu Lys Arg Lys  Glu Lys Val 
    1040                 1045             


<210>  8425
<211>  3690
<212>  DNA
<213>  Homosapiens

<400>  8425
cgggtggcgg gggtgagtgg ggccagcggg gctggacagc agcgggcccc gggcgccgcc     60

gccgcgatcc ctccccgcgc ccgccgagca catcgccgcc gccgagatgg gccctccgcg    120

gcacccccag gccggcgaga tagaagcggg cggtgcgggc ggcgggcggc ggctacaggt    180

ggaaatgagt tctcaacagt ttcctcggtt aggagcccct tctaccgggc tgagccaggc    240

cccttctcag attgcaaaca gtggttctgc tggattgata aacccagctg ctacagtcaa    300

tgatgaatct ggtcgagatt ctgaagtcag tgccagggag cacatgagtt ccagcagctc    360

cctccagtcc cgggaggaga agcaagagcc tgttgtggta aggccctatc cacaggtgca    420

gatgttgtcg acacaccatg ctgtcgcatc agccacacct gttgcagtga cagccccgcc    480

agcacacctg acgccagcag tgccactttc attttcggag ggacttatga agccgccccc    540

gaagcccacc atgcctagcc gtcccattgc tcctgctcca ccttctaccc tgtcacttcc    600

ccccaaggtt ccagggcagg ttaccgttac catggagagt agcatccctc aagcttcagc    660

cattcctgtg gcaacaatca gtggacaaca gggccatccc agtaacctgc atcacatcat    720

gactacaaat gtgcaaatgt ctatcatccg cagcaatgct cctgggcccc ctcttcacat    780

tggagcttct catttacctc gaggtgcagc tgctgctgct gtgatgtcca gttctaaagt    840

aaccacagtc ctgaggccga cctcacagct gccaaatgct gctactgctc agccagcagt    900

acagcacatc attcaccaac caatccagtc tcggccacct gtgaccacct ccaatgccat    960

ccctcctgct gtggtagcaa ctgtctcagc caccagagct cagtctccag tcatcactac   1020

gacagcggcg catgctactg attcagcact tagtaggcca accttgtcta tccagcatcc   1080

tccatctgca gcaatcagta ttcagcgtcc tgcccagtca cgagatgtca caacaagaat   1140

cacactacca tctcaccctg cattagggac gccaaaacag cagcttcata caatggctca   1200

gaaaacaatc ttcagtactg gcacgccagt ggctgcagcc acagtagcac ctattttggc   1260

aaccaacacc attccttcag cgaccacagc tggatctgtg tcacacacgc aagctcccac   1320

aagtaccatt gttaccatga cagtaccctc ccattcctcc catgctactg ctgtgaccac   1380

ctcaaacatc ccagtcgcca aggtggtgcc ccagcagatc acgcacactt ctcctcggat   1440

ccagccagac taccctgccg agaggagtag cctgattccc atctccggac atcgggcctc   1500

tcccaatcct gtggccatgg aaacccgaag tgacaacaga ccgtctgttc ccgttcagtt   1560

ccaatatttt ttgccaactt accccccttc tgcataccca ctggcggcac atacctacac   1620

cccaatcacc agttccgtgt ccactatccg acagtatcca gtttcagctc aggctccaaa   1680

ctctgccatc acagctcaga ctggtgttgg ggtagcgtct accgtccacc taaaccccat   1740

gcagttgatg acagtggatg catcgcatgc tcgacatatt caagggatcc agccagcacc   1800

catcagtacc cagggtatcc agccggcccc cattgggacc ccagggatac agcctgcacc   1860

acttggcaca cagggaattc actcagcaac cccaatcaac acacaagggc ttcagcctgc   1920

acctatgggt actcagcagc ctcagcctga aggaaagact tcagcagtgg tgttggcaga   1980

tggagccaca attgtggcca accctattag caatccattc agtgctgctc cagcagcaac   2040

aaccgtggtg cagacccaca gccagagtgc tagcaccaac gctcccgccc agggctcatc   2100

gccacggcca agcatactcc ggaagaaacc tgccacagat ggtgccaaac ccaagtctga   2160

aatccacgtg tctatggcca ctccggtcac tgtgtccatg gagactgtat ccaatcaaaa   2220

taatgatcag cctaccattg ccgtccctcc aactgcccag cagcccccac cgaccattcc   2280

aactatgatt gcagcagcca gtcccccgtc acaaccagcc gttgcccttt caaccattcc   2340

tggagcggtc cccatcactc cacccatcac caccattgca gctgcaccac ctccatcagt   2400

cactgtgggt ggcagtcttt cctccgtctt gggccctccc gttcctgaaa ttaaagtgaa   2460

agaagaagta gaaccaatgg atatcatgag gccagtttct gcagttcctc cactggctac   2520

caacactgtg tctccatctc ttgcattgct ggcaaacaac ttgtccatgc ctacaagtga   2580

cctaccacct ggtgcctccc caaggaaaaa gcctcgaaag caacagcatg tgatctcaac   2640

agaagaaggt gacatgatgg agacaaacag cactgatgat gagaagtcca ctgccaagag   2700

tcttctggtg aaggctgaga agcgcaagtc tcctcccaag gagtatattg atgaggaagg   2760

tgtgagatat gtcccagtgc gtccaagacc ccccattact ttgcttcgtc actatcggaa   2820

cccctggaaa gctgcttacc accactttca gaggtacagt gacgtccggg tcaaagagga   2880

gaagaaagct atgctgcagg aaatagctaa tcagaaagga gtatcctgtc gtgctcaagg   2940

ctggaaagtc cacctctgtg ctgcccagtt actacagctg acgaatctag aacatgatgt   3000

ctatgaaaga cttactaacc tgcaggaagg gattatccca aagaaaaaag cagcaacaga   3060

tgatgatctc caccgaataa acgaactgat acagggaaat atgcagaggt gtaaacttgt   3120

gatggatcaa atcagtgaag ccagagactc catgcttaag gttttagatc ataaagaccg   3180

tgtcctgaag ctgcttaaca agaacgggac tgtcaaaaaa gtgtccaaat tgaagcgaaa   3240

ggaaaaagtc tagacccaga acaatcagga gattggaagc aaatttatga agaatgatgg   3300

tgggggtggg gggagggttt tggttttttc caaagtggaa cattgaaata aaggaagtgt   3360

tccttagttc ccgtgtgaaa gcagaggaac ccatgacatc caagggcgtg aaaggatcag   3420

agctgactgg acatagtgag ctgccttctt gcgttcgggt gcacccctgt taaacctgat   3480

ctgtgtcata agtgactccg gatgcatcag tgtccaccag ttggaagcaa tgacaaggat   3540

ggctggctgg tgtttttcag ccttccggtt tatagactgt atttatctag tggattcctg   3600

caggccccat actgagcctg gactgaaagt atccactcgg accatctgtt atctctctac   3660

actgaaaata aaacctcttc cacccacccc                                    3690


<210>  8426
<211>  1048
<212>  PRT
<213>  Homosapiens

<400>  8426

Met Gly Pro Pro Arg His Pro Gln Ala Gly Glu Ile Glu Ala Gly Gly 
1               5                   10                  15      


Ala Gly Gly Gly Arg Arg Leu Gln Val Glu Met Ser Ser Gln Gln Phe 
            20                  25                  30          


Pro Arg Leu Gly Ala Pro Ser Thr Gly Leu Ser Gln Ala Pro Ser Gln 
        35                  40                  45              


Ile Ala Asn Ser Gly Ser Ala Gly Leu Ile Asn Pro Ala Ala Thr Val 
    50                  55                  60                  


Asn Asp Glu Ser Gly Arg Asp Ser Glu Val Ser Ala Arg Glu His Met 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Leu Gln Ser Arg Glu Glu Lys Gln Glu Pro Val 
                85                  90                  95      


Val Val Arg Pro Tyr Pro Gln Val Gln Met Leu Ser Thr His His Ala 
            100                 105                 110         


Val Ala Ser Ala Thr Pro Val Ala Val Thr Ala Pro Pro Ala His Leu 
        115                 120                 125             


Thr Pro Ala Val Pro Leu Ser Phe Ser Glu Gly Leu Met Lys Pro Pro 
    130                 135                 140                 


Pro Lys Pro Thr Met Pro Ser Arg Pro Ile Ala Pro Ala Pro Pro Ser 
145                 150                 155                 160 


Thr Leu Ser Leu Pro Pro Lys Val Pro Gly Gln Val Thr Val Thr Met 
                165                 170                 175     


Glu Ser Ser Ile Pro Gln Ala Ser Ala Ile Pro Val Ala Thr Ile Ser 
            180                 185                 190         


Gly Gln Gln Gly His Pro Ser Asn Leu His His Ile Met Thr Thr Asn 
        195                 200                 205             


Val Gln Met Ser Ile Ile Arg Ser Asn Ala Pro Gly Pro Pro Leu His 
    210                 215                 220                 


Ile Gly Ala Ser His Leu Pro Arg Gly Ala Ala Ala Ala Ala Val Met 
225                 230                 235                 240 


Ser Ser Ser Lys Val Thr Thr Val Leu Arg Pro Thr Ser Gln Leu Pro 
                245                 250                 255     


Asn Ala Ala Thr Ala Gln Pro Ala Val Gln His Ile Ile His Gln Pro 
            260                 265                 270         


Ile Gln Ser Arg Pro Pro Val Thr Thr Ser Asn Ala Ile Pro Pro Ala 
        275                 280                 285             


Val Val Ala Thr Val Ser Ala Thr Arg Ala Gln Ser Pro Val Ile Thr 
    290                 295                 300                 


Thr Thr Ala Ala His Ala Thr Asp Ser Ala Leu Ser Arg Pro Thr Leu 
305                 310                 315                 320 


Ser Ile Gln His Pro Pro Ser Ala Ala Ile Ser Ile Gln Arg Pro Ala 
                325                 330                 335     


Gln Ser Arg Asp Val Thr Thr Arg Ile Thr Leu Pro Ser His Pro Ala 
            340                 345                 350         


Leu Gly Thr Pro Lys Gln Gln Leu His Thr Met Ala Gln Lys Thr Ile 
        355                 360                 365             


Phe Ser Thr Gly Thr Pro Val Ala Ala Ala Thr Val Ala Pro Ile Leu 
    370                 375                 380                 


Ala Thr Asn Thr Ile Pro Ser Ala Thr Thr Ala Gly Ser Val Ser His 
385                 390                 395                 400 


Thr Gln Ala Pro Thr Ser Thr Ile Val Thr Met Thr Val Pro Ser His 
                405                 410                 415     


Ser Ser His Ala Thr Ala Val Thr Thr Ser Asn Ile Pro Val Ala Lys 
            420                 425                 430         


Val Val Pro Gln Gln Ile Thr His Thr Ser Pro Arg Ile Gln Pro Asp 
        435                 440                 445             


Tyr Pro Ala Glu Arg Ser Ser Leu Ile Pro Ile Ser Gly His Arg Ala 
    450                 455                 460                 


Ser Pro Asn Pro Val Ala Met Glu Thr Arg Ser Asp Asn Arg Pro Ser 
465                 470                 475                 480 


Val Pro Val Gln Phe Gln Tyr Phe Leu Pro Thr Tyr Pro Pro Ser Ala 
                485                 490                 495     


Tyr Pro Leu Ala Ala His Thr Tyr Thr Pro Ile Thr Ser Ser Val Ser 
            500                 505                 510         


Thr Ile Arg Gln Tyr Pro Val Ser Ala Gln Ala Pro Asn Ser Ala Ile 
        515                 520                 525             


Thr Ala Gln Thr Gly Val Gly Val Ala Ser Thr Val His Leu Asn Pro 
    530                 535                 540                 


Met Gln Leu Met Thr Val Asp Ala Ser His Ala Arg His Ile Gln Gly 
545                 550                 555                 560 


Ile Gln Pro Ala Pro Ile Ser Thr Gln Gly Ile Gln Pro Ala Pro Ile 
                565                 570                 575     


Gly Thr Pro Gly Ile Gln Pro Ala Pro Leu Gly Thr Gln Gly Ile His 
            580                 585                 590         


Ser Ala Thr Pro Ile Asn Thr Gln Gly Leu Gln Pro Ala Pro Met Gly 
        595                 600                 605             


Thr Gln Gln Pro Gln Pro Glu Gly Lys Thr Ser Ala Val Val Leu Ala 
    610                 615                 620                 


Asp Gly Ala Thr Ile Val Ala Asn Pro Ile Ser Asn Pro Phe Ser Ala 
625                 630                 635                 640 


Ala Pro Ala Ala Thr Thr Val Val Gln Thr His Ser Gln Ser Ala Ser 
                645                 650                 655     


Thr Asn Ala Pro Ala Gln Gly Ser Ser Pro Arg Pro Ser Ile Leu Arg 
            660                 665                 670         


Lys Lys Pro Ala Thr Asp Gly Ala Lys Pro Lys Ser Glu Ile His Val 
        675                 680                 685             


Ser Met Ala Thr Pro Val Thr Val Ser Met Glu Thr Val Ser Asn Gln 
    690                 695                 700                 


Asn Asn Asp Gln Pro Thr Ile Ala Val Pro Pro Thr Ala Gln Gln Pro 
705                 710                 715                 720 


Pro Pro Thr Ile Pro Thr Met Ile Ala Ala Ala Ser Pro Pro Ser Gln 
                725                 730                 735     


Pro Ala Val Ala Leu Ser Thr Ile Pro Gly Ala Val Pro Ile Thr Pro 
            740                 745                 750         


Pro Ile Thr Thr Ile Ala Ala Ala Pro Pro Pro Ser Val Thr Val Gly 
        755                 760                 765             


Gly Ser Leu Ser Ser Val Leu Gly Pro Pro Val Pro Glu Ile Lys Val 
    770                 775                 780                 


Lys Glu Glu Val Glu Pro Met Asp Ile Met Arg Pro Val Ser Ala Val 
785                 790                 795                 800 


Pro Pro Leu Ala Thr Asn Thr Val Ser Pro Ser Leu Ala Leu Leu Ala 
                805                 810                 815     


Asn Asn Leu Ser Met Pro Thr Ser Asp Leu Pro Pro Gly Ala Ser Pro 
            820                 825                 830         


Arg Lys Lys Pro Arg Lys Gln Gln His Val Ile Ser Thr Glu Glu Gly 
        835                 840                 845             


Asp Met Met Glu Thr Asn Ser Thr Asp Asp Glu Lys Ser Thr Ala Lys 
    850                 855                 860                 


Ser Leu Leu Val Lys Ala Glu Lys Arg Lys Ser Pro Pro Lys Glu Tyr 
865                 870                 875                 880 


Ile Asp Glu Glu Gly Val Arg Tyr Val Pro Val Arg Pro Arg Pro Pro 
                885                 890                 895     


Ile Thr Leu Leu Arg His Tyr Arg Asn Pro Trp Lys Ala Ala Tyr His 
            900                 905                 910         


His Phe Gln Arg Tyr Ser Asp Val Arg Val Lys Glu Glu Lys Lys Ala 
        915                 920                 925             


Met Leu Gln Glu Ile Ala Asn Gln Lys Gly Val Ser Cys Arg Ala Gln 
    930                 935                 940                 


Gly Trp Lys Val His Leu Cys Ala Ala Gln Leu Leu Gln Leu Thr Asn 
945                 950                 955                 960 


Leu Glu His Asp Val Tyr Glu Arg Leu Thr Asn Leu Gln Glu Gly Ile 
                965                 970                 975     


Ile Pro Lys Lys Lys Ala Ala Thr Asp Asp Asp Leu His Arg Ile Asn 
            980                 985                 990         


Glu Leu Ile Gln Gly Asn Met Gln  Arg Cys Lys Leu Val  Met Asp Gln 
        995                 1000                 1005             


Ile Ser  Glu Ala Arg Asp Ser  Met Leu Lys Val Leu  Asp His Lys 
    1010                 1015                 1020             


Asp Arg  Val Leu Lys Leu Leu  Asn Lys Asn Gly Thr  Val Lys Lys 
    1025                 1030                 1035             


Val Ser  Lys Leu Lys Arg Lys  Glu Lys Val 
    1040                 1045             


<210>  8427
<211>  765
<212>  DNA
<213>  Homosapiens

<400>  8427
ttgccagaaa ttgaggacgg actcccgccc tggtcgactg agctcccaca ggagcgcctc     60

tgctgcgtct cggggctgag tgtggacgcg ccgcgcgcgg ccccgccagg gctggtagtt    120

tgcagaccgt ccctgccgcg gcccgctcgg cggcggccct gcggctcccg cggcggcggc    180

cccgggcgcg atccagccca ggtagccgcg ccgcaggctc ggggcgtcgc gacctcgcgc    240

ctcgggccgc gtgggcacgg cggccggcgg gtgctcccgg ctgctgctgc tgcccaacaa    300

ggaggcaatg ggaaaacagt aagaggcaga ccaacagtga tccagggctc tgaaagctaa    360

ttgcttcaag atcctgctac cattttcttt tgggccgctt gcaaagaaga atcctttgac    420

tgaagcataa tggaagtgag gaaaggcaac cagctgacac aggagccaga gtgagaccag    480

cagactctca cactcaacct acaccatgaa tttgtgtcta tcttctacgc gttaagagcc    540

aaggacaggt gaagttgcca gagagcaatg gctctcttca ctccgtggaa gttgtcctct    600

cagaagctgg gctttttcct ggtgactttt ggcttcattt ggggtatgat gcttctgcac    660

tttaccatcc agcagcgaac tcagcctgaa agcagctcca tgctgcgcga gcagatcctg    720

gacctcagca aaaggtacat caaggcactg gcagaagaaa acagg                    765


<210>  8428
<211>  65
<212>  PRT
<213>  Homosapiens

<400>  8428

Met Ala Leu Phe Thr Pro Trp Lys Leu Ser Ser Gln Lys Leu Gly Phe 
1               5                   10                  15      


Phe Leu Val Thr Phe Gly Phe Ile Trp Gly Met Met Leu Leu His Phe 
            20                  25                  30          


Thr Ile Gln Gln Arg Thr Gln Pro Glu Ser Ser Ser Met Leu Arg Glu 
        35                  40                  45              


Gln Ile Leu Asp Leu Ser Lys Arg Tyr Ile Lys Ala Leu Ala Glu Glu 
    50                  55                  60                  


Asn 
65  


<210>  8429
<211>  559
<212>  DNA
<213>  Homosapiens

<400>  8429
gaattgatgg ccactgggca tctgttcctc actggagccc actgtgtgct cacacccagc     60

ttcaccttgg aatgtggtag ggagcaggag catggggtag gtgaggagtg acctggaaga    120

ggtatcagga ccattcctta acatttctga taatcggtgc ctgtgaagac attcccgcag    180

tgtctgcgga gtcctagaaa gagagcagag gccacacaaa atgcttttct gaacccaaga    240

tcgccatact ttgtggaatc ttcccattgg acatagcagt gagcacccgt ttcctttcct    300

gccctcacct gttcctgatt cggaatgctt ctgccaaata aatagtcact ggctacccaa    360

ggagtttaaa gtctaagcct ggtcaatgca cacccagaag agttaagttc agtgataaag    420

ggaaatgtag atgaacatac taattcagcc catgtgacca ctttgggcct cagctgttag    480

gttgagaagt aagaggggat tgaatgcgct ccaaagatcc gttcagttcc taatgttgct    540

taattctata catgtggca                                                 559


<210>  8430
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  8430

Met Ala Thr Gly His Leu Phe Leu Thr Gly Ala His Cys Val Leu Thr 
1               5                   10                  15      


Pro Ser Phe Thr Leu Glu Cys Gly Arg Glu Gln Glu His Gly Val Gly 
            20                  25                  30          


Glu Glu 
        


<210>  8431
<211>  598
<212>  DNA
<213>  Homosapiens

<400>  8431
tgaacagcaa acatctgtcg aggagttttt acagggtatt tgtactttca catgatctaa     60

ttttactatc ttcataagta gtatgaggct gggcatggtg gctaacgcct gcaatcccag    120

taccttggga ggctgaggcg ggcagatcac atgaggttag gagtttgaga ccagcctggc    180

caacatggtg aaaccctggc tgtcctttaa aaaaaaaatt agctggtcat ggtggtgcac    240

gcctgtaact ccaactgctt gggaggctga ggcaggagaa ttacttgaat ccaggaagtg    300

gaggttgcag tgagtcgaga tcacgccact gcagtgcagc ctgggtgaca gagcaggact    360

ccatgtcaaa aaaaaacaaa aacaaaatac acctgctctc cttaaagaaa tggttctcct    420

tgcagctcac catgtaattt tcttgtactc atggtgttag gaccttttgc tgaagactgg    480

cgggttgtca gctgaaactc tgggcctgat ttagggactt cccttaaaga atatgaccag    540

aaggagatgg cagtgaggca agcaaggagt ccaaaggtgt gtctttcttt tctagttg      598


<210>  8432
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  8432

Met Val Lys Pro Trp Leu Ser Phe Lys Lys Lys Ile Ser Trp Ser Trp 
1               5                   10                  15      


Trp Cys Thr Pro Val Thr Pro Thr Ala Trp Glu Ala Glu Ala Gly Glu 
            20                  25                  30          


Leu Leu Glu Ser Arg Lys Trp Arg Leu Gln 
        35                  40          


<210>  8433
<211>  5165
<212>  DNA
<213>  Homosapiens

<400>  8433
taatactcct ttattccctg ttttaaaaat ttttttaaat ttgatacaat aattatacat     60

aataatggag taccatgtga gattcaatcc acatatacat tgtgaaatga tcaaattagg    120

atagttagca tgcacatcac ccccaaataa ttattacttt tgtggtgaga acacttaaaa    180

ttgtctcttt tagaaatata cgttattatt aaccatagtc accttgctgt gcaatagaac    240

accagaactt attcctccta aatgtaactt tttacccatt gaccactccc tcctcatccc    300

cctctctcct ccccacccct ggtaaccact gttctgttat ctcctatgat agcaactttt    360

tagcttctgc atgtgagatt gtacggtagt tgcctttctg tgcctggatt atttcattta    420

gcataatgtc cttcgggtat atccctgttg ctgcaaaaga caggatttct ctctcttttt    480

ctggttgaat agtattccat tgtcagagaa gtgttgtaag actaggaaag gaacactgca    540

ggctggagcc ctggggaaag tggtctgagg caggtggtgg gactagagct ggggtctggc    600

aaacaggctg ggtttgattg tcagcataat agagagcact catgtgccag ctgggtggga    660

ggagcagccg agtgaagaag gggaagcctc tcaggaagca tgtgcagggt ttatggtaat    720

gagcagacca gcaggtacgt agtgggagag gggtgtgatg gggcagagga acttacgtta    780

tgatagtaca agacagaggt tgagcctcat tttaataggc attgtggtgg gtgttgaata    840

gtgatggaat gtatgggtct ggaatcaggc tgcctggtca agggctctga aacatgagtg    900

tgcatcagaa tcacctcgag gcttgttaaa ggataggctg tggaccacat ctcctcagtt    960

gctgattcag tgggtgtggg tggggcctga gaattcacat ttctcactgg tgatgctgct   1020

gttactgagt ttgggaccac atttggagaa ccactggtct agaattgaga ggttggcaaa   1080

ccttctctgt taagaggtag atagtaaata ttttaggcct tctgggctac aaagagtatc   1140

tgttacatat tttttattgc ttttcatgac ccattaagca tatatatatc attctctgcc   1200

atatacaaac aggctgttgg gggagtgagg atgatgtagg gaaggtgggg catggtttaa   1260

taacccctgg gccatgccta gatgatcagt cctctgccac atagctggct gacctttgcc   1320

aagttaatca ccttttacct ttattttctc atgtttctaa taaaacagag acgataatat   1380

tcatacttct taccatatag aacttctgag gattcagtga gcaaagccac aaaagatggt   1440

atgtcacaat atctgggata tagctagaat ttataattta tttttactct gttgataggc   1500

aatgggaaaa cagtaagagg cagaccaaca gtgatccagg gctctgaaag ctaattgctt   1560

caagatcctg ctaccatttt cttttgggcc gcttgcaaag aagaatcctt tgactgaagc   1620

atgtatgtac actctgaagt acagcctggg ttagtctctt ataagggatc ggatcattgc   1680

tcagcctctc ccttgagtgg cacttagaaa atggcgctat tcgtaagctg actggtattg   1740

ggcccaggac tctggctgaa ggggtgggca tgctggtaac catttgcaac ctatgctcag   1800

gtcctacttg ttgggaagcc ctgattgaga agagtggcct ggtctgtgct ggcattagat   1860

aggatctggc tgcattaata ttgaaactac tctgcctttt aatgtctcat tttgcctcat   1920

ggtgggagtg aaagtgagaa ccacagaaaa tctgcctgcc aggtgttcca catttcttgt   1980

gctacagcat gcaagtgagc agtgaggtgt accttttcct catgtagctg ggaaagcaat   2040

acccctgctt gtacctctgg catatcttct ctgtgctggt gcacctagag aggttgcctg   2100

gtggccctga gagagccatc tcatcactaa acactgatgg tgaaagctgg ccatgctcaa   2160

ataagatgta gcaatctacc tcttctttgt ctagttaccc ccaagggggc atccactttc   2220

ttgctcacct caccagttgc atgttctagt ccttgccaga agcacataat aatgactttg   2280

taagcttaag ttacaggcac acaaaagggc ctgatggtga tatgactcca ccctccccgt   2340

ttttgctgac attccgccaa atatccttct gtctcctccc caccttgcaa aacaaacttc   2400

ctgttttgaa tttggtccag gctggaacag ccccactaca cctgttaaca cacgcagacg   2460

cacacttccc ccttcataat tgcttagctt cttgttgcct agccagattt cccctcagct   2520

tacagttcct gaatcataag atattgaacc agcaaattta agagttgaca ttttacttag   2580

aggtattcaa gtgaaaacat ggcttctggt ttattttgct gtattgtgcc atgaccactt   2640

ggctaattct tctcctcctt cacagcagaa tggaagtgag gaaaggcaac cagctgacac   2700

aggagccaga gtgagaccag cagactctca cactcaacct acaccatgaa tttgtgtcta   2760

tcttctacgc gttaagagcc aaggacaggt gaagttgcca gagagcaatg gctctcttca   2820

ctccgtggaa gttgtcctct cagaagctgg gctttttcct ggtgactttt ggcttcattt   2880

ggggtatgat gcttctgcac tttaccatcc agcagcgaac tcagcctgaa agcagctcca   2940

tgctgcgcga gcagatcctg gacctcagca aaaggtacat caaggcactg gcagaagaaa   3000

acaggaatgt ggtggatggg ccatacgctg gagtcatgac agcttatgat ctgaagaaaa   3060

cccttgctgt gttattagat aacattttgc agcgcattgg caagttggag tcgaaggtgg   3120

acaatcttgt tgtcaatggc accggaacaa actcaaccaa ctccactaca gctgttccca   3180

gcttggttgc acttgagaaa attaatgtgg cagatatcat taacggagct caagaaaaat   3240

gtgtattgcc tcctatggac ggctaccctc actgtgaggg aaagatcaag tggatgaaag   3300

acatgtggcg ttcagatccc tgctacgcag actatggagt ggatggatcc acctgctctt   3360

tttttattta cctcagtgag gttgaaaatt ggtgtcctca tttaccttgg agagcaaaaa   3420

atccctacga agaagctgat cataattcat tggcggaaat tcgtacagat tttaatattc   3480

tctacagtat gatgaaaaag catgaagaat tccggtggat gagactacgg atccggcgaa   3540

tggctgacgc atggatccaa gcaatcaagt ccctggcaga aaagcagaac cttgaaaaga   3600

gaaagcggaa gaaagtcctc gttcacctgg gactcctgac caaggaatct ggatttaaga   3660

ttgcagagac agctttcagt ggtggccctc ttggtgaatt agttcaatgg agtgatttaa   3720

ttacatctct gtacttactg ggccatgaca ttaggatttc agcttcactg gctgagctca   3780

aggaaatcat gaagaaggtt gtaggaaacc gatctggctg cccaactgta ggagacagaa   3840

ttgttgagct catttacatt gatattgtag gacttgctca attcaagaaa actcttggac   3900

catcctgggt tcattaccag tgcatgctcc gagtccttga ttcatttggt actgaacccg   3960

aatttaatca tgcaaattat gcccaatcga aaggccacaa gaccccttgg ggaaaatgga   4020

atctgaaccc tcagcagttt tataccatgt tccctcatac cccagacaac agctttctgg   4080

ggtttgtggt tgagcagcac ctgaactcca gtgatatcca ccacattaat gaaatcaaaa   4140

ggcagaacca gtcccttgtg tatggcaaag tggatagctt ctggaagaat aagaagatct   4200

acttggacat tattcacaca tacatggaag tgcatgcaac tgtttatggc tccagcacaa   4260

agaatattcc cagttacgtg aaaaaccatg gtatcctcag tggacgggac ctgcagttcc   4320

ttcttcgaga aaccaagttg tttgttggac ttgggttccc ttacgagggc ccagctcccc   4380

tggaagctat cgcaaatgga tgtgcttttc tgaatcccaa gttcaaccca cccaaaagca   4440

gcaaaaacac agactttttc attggcaagc caactctgag agagctgaca tcccagcatc   4500

cttacgctga agttttcatc gggcggccac atgtgtggac tgttgacctc aacaatcagg   4560

aggaagtaga ggatgcagtg aaagcaattt taaatcagaa gattgagcca tacatgccat   4620

atgaatttac gtgcgagggg atgctacaga gaatcaatgc tttcattgaa aaacaggact   4680

tctgccatgg gcaagtgatg tggccacccc tcagcgccct acaggtcaag cttgctgagc   4740

ccgggcagtc ctgcaagcag gtgtgccagg agagccagct catctgcgag ccttctttct   4800

tccagcacct caacaaggac aaggacatgc tgaagtacaa ggtgacctgc caaagctcag   4860

agctggccaa ggacatcctg gtgccctcct ttgaccctaa gaataagcac tgtgtgtttc   4920

aaggtgacct cctgctcttc agctgtgcag gcgcccaccc caggcaccag agggtctgcc   4980

cctgccggga cttcatcaag ggccaggtgg ctctctgcaa agactgccta tagcagctac   5040

ctgctcagcc ctgcaccatg ctgctgggga agacagtggc cccagccccg tcaggcaggg   5100

ccagggacag aagtcatgca gggactctgg caagagcctg aactttttcg tagaaggttc   5160

tgaat                                                               5165


<210>  8434
<211>  741
<212>  PRT
<213>  Homosapiens

<400>  8434

Met Ala Leu Phe Thr Pro Trp Lys Leu Ser Ser Gln Lys Leu Gly Phe 
1               5                   10                  15      


Phe Leu Val Thr Phe Gly Phe Ile Trp Gly Met Met Leu Leu His Phe 
            20                  25                  30          


Thr Ile Gln Gln Arg Thr Gln Pro Glu Ser Ser Ser Met Leu Arg Glu 
        35                  40                  45              


Gln Ile Leu Asp Leu Ser Lys Arg Tyr Ile Lys Ala Leu Ala Glu Glu 
    50                  55                  60                  


Asn Arg Asn Val Val Asp Gly Pro Tyr Ala Gly Val Met Thr Ala Tyr 
65                  70                  75                  80  


Asp Leu Lys Lys Thr Leu Ala Val Leu Leu Asp Asn Ile Leu Gln Arg 
                85                  90                  95      


Ile Gly Lys Leu Glu Ser Lys Val Asp Asn Leu Val Val Asn Gly Thr 
            100                 105                 110         


Gly Thr Asn Ser Thr Asn Ser Thr Thr Ala Val Pro Ser Leu Val Ala 
        115                 120                 125             


Leu Glu Lys Ile Asn Val Ala Asp Ile Ile Asn Gly Ala Gln Glu Lys 
    130                 135                 140                 


Cys Val Leu Pro Pro Met Asp Gly Tyr Pro His Cys Glu Gly Lys Ile 
145                 150                 155                 160 


Lys Trp Met Lys Asp Met Trp Arg Ser Asp Pro Cys Tyr Ala Asp Tyr 
                165                 170                 175     


Gly Val Asp Gly Ser Thr Cys Ser Phe Phe Ile Tyr Leu Ser Glu Val 
            180                 185                 190         


Glu Asn Trp Cys Pro His Leu Pro Trp Arg Ala Lys Asn Pro Tyr Glu 
        195                 200                 205             


Glu Ala Asp His Asn Ser Leu Ala Glu Ile Arg Thr Asp Phe Asn Ile 
    210                 215                 220                 


Leu Tyr Ser Met Met Lys Lys His Glu Glu Phe Arg Trp Met Arg Leu 
225                 230                 235                 240 


Arg Ile Arg Arg Met Ala Asp Ala Trp Ile Gln Ala Ile Lys Ser Leu 
                245                 250                 255     


Ala Glu Lys Gln Asn Leu Glu Lys Arg Lys Arg Lys Lys Val Leu Val 
            260                 265                 270         


His Leu Gly Leu Leu Thr Lys Glu Ser Gly Phe Lys Ile Ala Glu Thr 
        275                 280                 285             


Ala Phe Ser Gly Gly Pro Leu Gly Glu Leu Val Gln Trp Ser Asp Leu 
    290                 295                 300                 


Ile Thr Ser Leu Tyr Leu Leu Gly His Asp Ile Arg Ile Ser Ala Ser 
305                 310                 315                 320 


Leu Ala Glu Leu Lys Glu Ile Met Lys Lys Val Val Gly Asn Arg Ser 
                325                 330                 335     


Gly Cys Pro Thr Val Gly Asp Arg Ile Val Glu Leu Ile Tyr Ile Asp 
            340                 345                 350         


Ile Val Gly Leu Ala Gln Phe Lys Lys Thr Leu Gly Pro Ser Trp Val 
        355                 360                 365             


His Tyr Gln Cys Met Leu Arg Val Leu Asp Ser Phe Gly Thr Glu Pro 
    370                 375                 380                 


Glu Phe Asn His Ala Asn Tyr Ala Gln Ser Lys Gly His Lys Thr Pro 
385                 390                 395                 400 


Trp Gly Lys Trp Asn Leu Asn Pro Gln Gln Phe Tyr Thr Met Phe Pro 
                405                 410                 415     


His Thr Pro Asp Asn Ser Phe Leu Gly Phe Val Val Glu Gln His Leu 
            420                 425                 430         


Asn Ser Ser Asp Ile His His Ile Asn Glu Ile Lys Arg Gln Asn Gln 
        435                 440                 445             


Ser Leu Val Tyr Gly Lys Val Asp Ser Phe Trp Lys Asn Lys Lys Ile 
    450                 455                 460                 


Tyr Leu Asp Ile Ile His Thr Tyr Met Glu Val His Ala Thr Val Tyr 
465                 470                 475                 480 


Gly Ser Ser Thr Lys Asn Ile Pro Ser Tyr Val Lys Asn His Gly Ile 
                485                 490                 495     


Leu Ser Gly Arg Asp Leu Gln Phe Leu Leu Arg Glu Thr Lys Leu Phe 
            500                 505                 510         


Val Gly Leu Gly Phe Pro Tyr Glu Gly Pro Ala Pro Leu Glu Ala Ile 
        515                 520                 525             


Ala Asn Gly Cys Ala Phe Leu Asn Pro Lys Phe Asn Pro Pro Lys Ser 
    530                 535                 540                 


Ser Lys Asn Thr Asp Phe Phe Ile Gly Lys Pro Thr Leu Arg Glu Leu 
545                 550                 555                 560 


Thr Ser Gln His Pro Tyr Ala Glu Val Phe Ile Gly Arg Pro His Val 
                565                 570                 575     


Trp Thr Val Asp Leu Asn Asn Gln Glu Glu Val Glu Asp Ala Val Lys 
            580                 585                 590         


Ala Ile Leu Asn Gln Lys Ile Glu Pro Tyr Met Pro Tyr Glu Phe Thr 
        595                 600                 605             


Cys Glu Gly Met Leu Gln Arg Ile Asn Ala Phe Ile Glu Lys Gln Asp 
    610                 615                 620                 


Phe Cys His Gly Gln Val Met Trp Pro Pro Leu Ser Ala Leu Gln Val 
625                 630                 635                 640 


Lys Leu Ala Glu Pro Gly Gln Ser Cys Lys Gln Val Cys Gln Glu Ser 
                645                 650                 655     


Gln Leu Ile Cys Glu Pro Ser Phe Phe Gln His Leu Asn Lys Asp Lys 
            660                 665                 670         


Asp Met Leu Lys Tyr Lys Val Thr Cys Gln Ser Ser Glu Leu Ala Lys 
        675                 680                 685             


Asp Ile Leu Val Pro Ser Phe Asp Pro Lys Asn Lys His Cys Val Phe 
    690                 695                 700                 


Gln Gly Asp Leu Leu Leu Phe Ser Cys Ala Gly Ala His Pro Arg His 
705                 710                 715                 720 


Gln Arg Val Cys Pro Cys Arg Asp Phe Ile Lys Gly Gln Val Ala Leu 
                725                 730                 735     


Cys Lys Asp Cys Leu 
            740     


<210>  8435
<211>  301
<212>  DNA
<213>  Homosapiens

<400>  8435
caccaaccag acagagtaac aatgaaactc actggctatc caaaagccag ggatgaaaaa     60

caacaaaaat acaaaatttt catgatgata taataggaag ctctcgaagg ttggattcag    120

gttctgcttt tctgccaggg acttgattgc ttggatccat gcgtcagcca ttcgccggat    180

ccgtagtctc atccaccgga attcttcatg ctttttcatc atactgtaga gaatattaaa    240

atctgtacga atttccgcct agcaacagaa atttaataaa atgaatagaa gataaaaagt    300

c                                                                    301


<210>  8436
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  8436

Tyr Asn Arg Lys Leu Ser Lys Val Gly Phe Arg Phe Cys Phe Ser Ala 
1               5                   10                  15      


Arg Asp Leu Ile Ala Trp Ile His Ala Ser Ala Ile Arg Arg Ile Arg 
            20                  25                  30          


Ser Leu Ile His Arg Asn Ser Ser Cys Phe Phe Ile Ile Leu 
        35                  40                  45      


<210>  8437
<211>  432
<212>  DNA
<213>  Homosapiens

<400>  8437
gctcataccc cagacaacag ctttctgggg tttgtggttg agcagcacct gaactccagt     60

gatatccacc acattaatga aatcaaaagg cagaaccagt cccttgtgta tggcaaagtg    120

gatagcttct ggaagattga gctccttgag gagatgataa tggctgacat tttagtgctt    180

cctgtgttcc aggcatggcc ttcacaatga ctatgaagta aatactatta ttaaccccac    240

ttttgagtga aagaactgaa gcagatagag gtaaaggttc ctcaggtggt caggatttga    300

attacatcat gtattgtagc caacacactg gactacaagg aatggattct ctcttggtaa    360

tttcctcctc tgtctccaac ccatcctctc aaatcccaaa agcctaaata aatacattta    420

tgttggtgtg gt                                                        432


<210>  8438
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  8438

Met Tyr Cys Ser Gln His Thr Gly Leu Gln Gly Met Asp Ser Leu Leu 
1               5                   10                  15      


Val Ile Ser Ser Ser Val Ser Asn Pro Ser Ser Gln Ile Pro Lys Ala 
            20                  25                  30          


<210>  8439
<211>  393
<212>  DNA
<213>  Homosapiens

<400>  8439
ggcagaacca gtcccttgtg tatggcaaag tggatagctt ctggaaggtg agtcagtctc     60

gaacttggga agcattttgc tcattgtcct acccaagtat taatagcata atagttgatg    120

ccaaaggaga tggtgacgtc ccttccactg tagttgctgt cacaaccttg acgtctttaa    180

gctaatggcc gtttgcatct gtgtcttcaa acagatcctg gttacagcca ttttgtgtga    240

ttcacttcgg gggttaagta atgcaggatt ctgcaaacaa ggtgtcgccg tccaaatgta    300

ctgtcctggc atagagagca ctgctttgtt ttccactgtt gtagagaaaa ctagggagaa    360

ctttattttt caataaactt ttcttgtgtg aca                                 393


<210>  8440
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  8440

Met Ala Val Cys Ile Cys Val Phe Lys Gln Ile Leu Val Thr Ala Ile 
1               5                   10                  15      


Leu Cys Asp Ser Leu Arg Gly Leu Ser Asn Ala Gly Phe Cys Lys Gln 
            20                  25                  30          


Gly Val Ala Val Gln Met Tyr Cys Pro Gly Ile Glu Ser Thr Ala Leu 
        35                  40                  45              


Phe Ser Thr Val Val Glu Lys Thr Arg Glu Asn Phe Ile Phe Gln 
    50                  55                  60              


<210>  8441
<211>  2445
<212>  DNA
<213>  Homosapiens

<400>  8441
aaaagctgca aggatcattt gctggctgtc cctaagttca aggcctccct accttcccct     60

tcttttccaa gtcacaaccc gccctgcccg ggccagacag cccagaagaa cacttttctg    120

ccatttaaaa atccctcttt catccccccc agtccagtat tgagtggaag tgcgccggag    180

ttccactgac agggcagctg ctcttggagc aaacaagccc acactccagt tgtttagggc    240

attatctgaa gagtcagtga cccctgaatg tgtactggct cccaggcctc ctcagacttg    300

gcccaggtct agtcagtgat cctggagagg aaactgggga gggggcttcc aactgccctg    360

catggaagag gagaggaagg tgcccctgtg tgggctggaa gcctgcggag gttttgccat    420

tgctgatctt gatagaatcc taaaccgatt tatagctgat aacagttcca tggggagaga    480

aatcctaagt tatgattaat gtttttcccc gctataatat cttgcctgtt tttttggatt    540

attttcccca ttgtgatcct aagctcttaa aaaacttgag ggaaaacatt catctaattt    600

actaaaagag aaagctttcc attgaaaggt agatactttg aggagtaaaa agacttcttt    660

gaatgctggt aaacaccgca tttattttgt gtatgcagtt tgatttgcac atgtataaat    720

ggagatgctt ttcatttttg tttggactgg gtttgtgtca ctgctcatta cagtttgctt    780

ttttgtgtgt ttgctgtgcg tttggagata ttagtcagtt tctttagtga tatttgtttc    840

cttgatgtgc cttttcgttt ttctttgggg tttttggaat ccggatgctg ttgaagggca    900

atagcagact cctccagcta agagacagga catgttcttg agccactgta gctgttgaag    960

ctggacacca gacgctccct ataacccccc cgccaggcca tagcgtgtat gcatgtgcac   1020

ttccacccac agaggagggt gtgaagcctt gagaacctca agaaagggct ggattctgcc   1080

atacctttgg gtctaccttg ggactgctgg ttgccaacgt gtcaaccagc ctgtgttccc   1140

tgccacccac gcacttgctg aggtgtggct gaggcagaat catgtgaatg ggtgcatcca   1200

aggagttcag ggccctgctt ggagaagaaa tagtctttca gaacattcca agggttttcc   1260

tcaaggaaca tttttgagct agaaattaaa atgggttctc tggcagactg caccccttga   1320

gtcaaagtta acagtattcc tttgaatgca ataatagagg cttttctgcg ttaagggaga   1380

aggaatgacc aattgaactt acacattccc caggcaggtc cctttgccgg cccctacagg   1440

ctggggtggc ccctcctgtc ctcagggatc agactcccag actggttagt tctgcatgtt   1500

tccatcaaat taaaggttat tccctggccg cctcctggag aaaaccaacc ccaccctgcc   1560

agctgggggc aatggggcag ggattttggc ctctcagaac agctcctaga ggctgctcat   1620

gactgaatgt tttcccaaat cacctaaata tcggtttgct ttttgttttg ggggagagga   1680

tttagcctct tacttccctg atggattcaa agttttatct atctccttat ctcctgccct   1740

gtcttggcac aactctggat agattgcagg tgtggaattt gctggagttt ggtgacttcg   1800

tcaaattcct ttggattctg ttccgccaaa tcagcagtct cgtcctgtgg atgcagtgac   1860

tggaatttcc catctgcaaa gcatctctgt agcccagatt ttgtggagcc ttaagacact   1920

ccctcaatgc caccctgacc ccacggctgg agaaccctgt gcttatgtgg tgggcagggc   1980

cactgttgat ggaggatggc ggggacgggg tggtgctcaa aggatctgtg gtgctggagg   2040

tctacacgcc tctcaggaca gcgtgtcagg aacctcagag cagcttcaca tctgccaaag   2100

ctgagaggga gcgaacttgg gaagcatttt gctcattgtc ctacccaagt attaatagca   2160

taatagttga tgccaaagga gatggtgacg tcccttccac tgtagttgct gtcacaacct   2220

tgacgtcttt aagctaatgg ccgtttgcat ctgtgtcttc aaacagatcc tggttacagc   2280

cattttgtgt gattcacttc gggggttaag taatgcagga ttctgcaaac aaggtgtcgc   2340

cgtccaaatg tactgtcctg gcatagagag cactgctttg ttttccactg ttgtagagaa   2400

aactagggag aactttattt ttcaataaac ttttcttgtg tgaca                   2445


<210>  8442
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  8442

Met Cys Thr Ser Thr His Arg Gly Gly Cys Glu Ala Leu Arg Thr Ser 
1               5                   10                  15      


Arg Lys Gly Trp Ile Leu Pro Tyr Leu Trp Val Tyr Leu Gly Thr Ala 
            20                  25                  30          


Gly Cys Gln Arg Val Asn Gln Pro Val Phe Pro Ala Thr His Ala Leu 
        35                  40                  45              


Ala Glu Val Trp Leu Arg Gln Asn His Val Asn Gly Cys Ile Gln Gly 
    50                  55                  60                  


Val Gln Gly Pro Ala Trp Arg Arg Asn Ser Leu Ser Glu His Ser Lys 
65                  70                  75                  80  


Gly Phe Pro Gln Gly Thr Phe Leu Ser 
                85                  


<210>  8443
<211>  2527
<212>  DNA
<213>  Homosapiens

<400>  8443
aaggtgggtt aatcccagta ggagcaatcc aatccaatct gggaaggagg gagggaggaa     60

catcgcaaga accagccctt gttcctgtta caggaacagt tacaggtggg tggtggatgt    120

ggtgtgggga atatgaggta tcctcgacca aacctcggtg tcctgagcac aggggagaga    180

agggcgtgcc accaagtgcg ttgtagggtc caggccagtc cctggggtgc ccttgcaggt    240

ccgcggttca tcttccattc ctgtgagcgg ccattgcatc cctgccttgg atcctgagta    300

gatttgctca ggtcatccct gcctggcaat cttcctctgc cccaggggaa gccaggcctg    360

gcgtgggagg ttacgggcct gcacaaacct accagcaggg cctccttggg cagcgtggac    420

ctggagcttc tcttggggcc accagtgtgt tggggcaggg gaggagctgg tgtccttcgc    480

ggggagaccc tagaagctac cttaagccat tcccttccct tcccatgtgg cctttgacag    540

ctctggtaaa gtagaagtat cacatgtaag ctgggagccc cagtgggctg ctgtgtgaaa    600

ggagatggca gtcactatct agtagctcca gttctgtttt tatggccatt tctccaacca    660

tgtagccaat actttgcaaa aaacttagca taatagactt tacatttctc ttctggaggg    720

aaaggaaaaa acctcaggtt acttagagga gactcgggag ggaaaggatg caggttggga    780

tagaatgccc ttctcaatct ggataacctc catcaatgta tttaacctca ttcttagttt    840

tctcatcgga aagcagggat gatgatgata atgtgacgtc acacgattga gaaaggttat    900

aggtaaccac acgtcctgaa cacccaactc ggaatctggc ccagcagaca ctcagatatg    960

agtccccaag tatttgaatg tctactgtga gcctggaact gtcctgggga ctgtggactc   1020

aacagaaaac cacacccctg cctctaggag gtttgcgttc tagcgggcac gggcgagacc   1080

agctataaac cacatatggc gtcagttccc agaagagaaa taaagcaggt acagaatgat   1140

ggtgggggtg acggctctat tctgggaggt atctggtgac atttgagcag agacttgatg   1200

ggcccaggtg gtggctatca ctcgtgagag ctttgggcat cattcctccc agcacatgct   1260

ccagttacgt ggaggcagga ctggcatttg ggtgattttc ttggattgct tggcactgcc   1320

atctagcctc tctccacttc ctttgcaggg tttaactccc tcgtgggtgg cgtgatgggc   1380

ttctccattc ttctgagcgc ggaagtgttc aagcatgact cggcggtctg gtacctggac   1440

ggcagcatag gcgttctgat cggcctcacc atatttgcct atggggtcaa actcctcatc   1500

gacatggtgc cgagggtgag gcagacacgt cactacgaga tgtttgagtg aagggggcca   1560

gcatccgcat gagaccatcg agatgaggag tttccacata ggcaaagggt gccaatattt   1620

aactgaacat ctggtttctt tttggaagtt ttctttcaca tggtttgtca ttacaagaca   1680

aggtctgccc agccaggtgg atctaccttg cccccatcac ctgccgcccc catcaaacat   1740

gttgggacaa tgcccatagg aatggacctc cttccccgtc tccagctggg actggcgttt   1800

tttagtctct ggagtatgat ggttctcatg ggtaggatga gatctttggc agaaaggtct   1860

tcggtggtgc tctgagcctg cgctgcatag gactgagcag acccacctcc tccagcttgg   1920

gtggccctgc cactcctggt tccaagtctc tcctttcctg gcaggtctta agggaagatt   1980

gtacccctca ccctttacat acccagaatc atcagtatgt cacttcctaa tttctatcag   2040

tgtatctcat tatttcatac tgttttacta atcctaagtc taaacagatt tgctcaaaag   2100

gagaccattc tattttttaa agtacttagt gatacacgta taagctttgc atggacgaat   2160

taaataagca cattgacctt ttcttgtaca ttcagaacct gaacatccat gtgaaaactg   2220

ggtccatttt tgagagatgt gaaactacag tttatttgta ataaataaat ataatctatc   2280

cgtatatgca tatatctata tgctgtgtta agtggtaatg ggtacattac agtctgtgag   2340

agatggatcg ctccctctgt aaggaacaag acgttctcag ctgatgtcac ggtaggttta   2400

gattctgtag agtgttcccc aacccgcacc gttctgtacc tctcacacca ctgcttgccc   2460

gggcagtagt ggctgaccaa taaagacctt tacctgtttt gtatggcatg ggaaggcaat   2520

ctttggc                                                             2527


<210>  8444
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  8444

Met Gly Phe Ser Ile Leu Leu Ser Ala Glu Val Phe Lys His Asp Ser 
1               5                   10                  15      


Ala Val Trp Tyr Leu Asp Gly Ser Ile Gly Val Leu Ile Gly Leu Thr 
            20                  25                  30          


Ile Phe Ala Tyr Gly Val Lys Leu Leu Ile Asp Met Val Pro Arg Val 
        35                  40                  45              


Arg Gln Thr Arg His Tyr Glu Met Phe Glu 
    50                  55              


<210>  8445
<211>  5102
<212>  DNA
<213>  Homosapiens

<400>  8445
aacccctcta agtgatgcag aataggggtt tgtggcaggg gtgcgacttt ccacatggtg     60

gttgctggtg ccgacgtcct ggtaaagcgg ttgcctctga gtgtggtgtt ggtctgaagt    120

cagcagccgt gcagtcagga aagaaggctg ggcaaagaga aaggcgcaag gacaaactgg    180

cgcccatgaa gatggcctgg acctgtacgt gaccctcact gtctcagcct ccatgacatt    240

gggcatcctg cagaagaagc tggcgccttt gccacagagc tatatgcacg cctggcttat    300

gactcagcga agctggagcg gggagatgca gcaggagcgg agaatccatg ggctcggtgc    360

ggcccctctc tcccctgggc gagcccgtgg agccacagaa tgcagaatgt gcctggctga    420

gctgcggcag caccggagcc gcttcacctc cacctttcac tcatgcagat gtctctggga    480

gtcagcttca actgggaacc acgtaggaag gaaattctgg gcaacgtagt tccagttgag    540

ctctgtgcac gcagtatatg cagccaccgt gagggagtct gttatttttt tccactttat    600

aggtaggaca gtggagggag ggaggggtta agtgacctgc ccagagtcac ctagctagta    660

agtgggactc ccgcttcagt gcttttgaag ctgccaccca gtgcttctac tttttcgctc    720

caggaagccc acccgagtcc tccaggagct ggacctcggg gccctccggt ccatcgagag    780

ctcccccgag atgaagcctc ccaggtacag gaaacttccc gcacagcccc tggataggcc    840

gcggtggagc tcagtcctgg tctcttggaa gttgaagttt ctttatgttt caccatgcat    900

acttatttct cggtgacaag cttcctgtgt ctctcttacg agaatgctga ccaggcttgt    960

ctggggctca ccgtgagcac ccgatgcggc tggcaggtgg aggacgtttg tgtgtggatc   1020

atgtgtttgg gccccttcac aacaactcgt accttttact gccagctgct gccaggggct   1080

gtaggcatcc cactgccgct tacagagatc caagtgtttg tttcccagta agccatggag   1140

tttagagttg agcaaaggcc tgcctggcac acgactgcca ctgggtcggc cgagccctgg   1200

gtctgcagct ccctttagga gctggaggaa gggccaccaa agccatgggt ggcgtttctt   1260

gagctgcatc tcagggtggg gcagcacacc ccaggccctg tgccctaggg gcctagatgg   1320

ggtaagcaca gattttctct accgctggaa acttagggag gagggctttg caaacagcga   1380

ctgaatggag ccaaagggga ttcaggcatc atgggataag caaagtgagt attcagtctc   1440

caaatctgag acctcaaagt tcttgaattt cctgactgcc tcagtctccc agcctatgct   1500

tcctgagtcc tgttagcacc tggggctgtt gacatgcaat tctttggtca tgtgtcttag   1560

tcagttctag ctgttataac aaaacaccac agactgggtg gcttataaac cacagacact   1620

tccatctcac agttctggag gctgggagtc caagacaagg tgccagcaga ttcagtgcct   1680

ggtggggccc cttttcctgg ttcatgagat ggtggcttct tcctgtgtcc tcacatgcgg   1740

agggggcaag ctggcactat gggacctctt ttataagggc actcattcca ttagtgaggg   1800

ctctgtcctt gcagcctaat cacctcccag aggccccacc tcctcatacc gtcaccctgg   1860

caattaggtt tccatgtgtg aattttggag ggacacatac tcagattgta gcatcatgtt   1920

caccttattt tctgtgggtg ctgtctcctg gacttaggct gagtcctgca caaagagagc   1980

ttccatgtgg ggctcctgac cccctcccac tgtgtcccct gctgtgtaac ctctgcatag   2040

gagggactga agagttgtca agaggcctgg tttgggacgg tccttactgg tcatttgagg   2100

aggtaaaact tccgtgaggt gattacttta aataagcttt taaatgtgaa ataattttag   2160

attaatagaa gagttttaca gatagtacag agagtgccca tatcccctcc atccagcctg   2220

acctactgtt aacatcgcac acagccacgg caaattaatc tctaccatga gatgacagca   2280

ctattcacga aaccctagac tttcttctca tgtccccggt tttcccactg atgacctttt   2340

tgtgttccag gatccagtct ggatgccatg ctgcatttac ttgtcacatc tccttaagtc   2400

tccagtgtgt gacagtctct cggtcgttcc tcatgtttca tgaccttgac acgtgaggag   2460

tcgggtattt tgtagacggt ccctccgttt gggtttgttt gatgttgttt cgcagttaaa   2520

atgaggttat ggatttgggg atggaacacc gtggaggtaa agtgcccttc ttgtcacatc   2580

gtatcagggg ccacatgtta ccaacacaac ttaataatgg tgatgtgaac cttgatcact   2640

tggctaaggt ggtgtctgct tggtttctcc attggtaagc tactgttttt ccctttctct   2700

actctgtgtt agatttgagt ctgttaagtc cagcccaaac tcaagggcag gggatggggt   2760

ggggagatta atctccaact cttggaggat ggagtagcaa agaatttgtg aacataggtt   2820

gccaaaacca ccaccgtcat tgacccatgt tttcggagag atgctttgac cctatacaga   2880

taccctgttt ccagtgaagt tgcttttcaa atggctttgt tcagttttga acatgatgca   2940

ggctgtctcc ctcttcccag gttctgacat gaggtttgtg aatttgatta ataaaatgca   3000

tagggagaag ccgatttctt tgcctattta tgatgctgca tcagagttct gctggccgtt   3060

gcattttaat attgggaaat ctgaaggctg tgtctcttgg gggtgacaca tgggagcttg   3120

aagcagaaga gctggatggg ccccaatgtc aggagaatag tggtgcttac ttattgcata   3180

tgggactcac ttgtttgctt gcgaaggtaa ggtaacaact tagaggaagt gttaagataa   3240

cgtcagtagc agacgatatt tttagatgct attttctcta cccatgtcta tgaactctca   3300

attgccctgt gtgaatttaa ggggaaaaaa tatggtttta agtagctctg gccctaactg   3360

accctgtggc aaattcagtt ggctctgttg aaggattgtt aggctggtgg tgtgtttacg   3420

tgttccaaaa ttctcagtca actgcttggt gagttatctg tggaaaattc tatatagaag   3480

atgctgttct tagcattctg accaactctg ttattgatct atgactgcta ctcattttag   3540

cagaatagtg gggaggtcaa tctcctacag gaaaataaat acgtaatggt tttttaagta   3600

aatataaatt gggattatct gtttttgagc atcttttcca attcctggtg acacataact   3660

gaggtgtgaa agcatgcagt atacccccac ctggtggcag cacacctgac tatttgtact   3720

tggaacaagg ctgatctgta aggcaagtgg gttgcagatg atctgctcca gcaggaggtg   3780

aactgttgaa atctggaact ttctcttgca ggacgatttc ctgttcagtg tctccatttt   3840

aagtgggatt ctttgcagca tcctggccgt gttgaagttc atgctgggga aggttctgac   3900

cagtagagca ctcataacag atgggtttaa ctccctcgtg ggtggcgtga tgggcttctc   3960

cattcttctg agcgcggaag tgttcaagca tgactcggcg gtctggtacc tggacggcag   4020

cataggcgtt ctgatcggcc tcaccatatt tgcctatggg gtcaaactcc tcatcgacat   4080

ggtgccgagg gtgaggcaga cacgtcacta cgagatgttt gagtgaaggg ggccagcatc   4140

cgcatgagac catcgagatg aggagtttcc acataggcaa agggtgccaa tatttaactg   4200

aacatctggt ttctttttgg aagttttctt tcacatggtt tgtcattaca agacaaggtc   4260

tgcccagcca ggtggatcta ccttgccccc atcacctgcc gcccccatca aacatgttgg   4320

gacaatgccc ataggaatgg acctccttcc ccgtctccag ctgggactgg cgttttttag   4380

tctctggagt atgatggttc tcatgggtag gatgagatct ttggcagaaa ggtcttcggt   4440

ggtgctctga gcctgcgctg cataggactg agcagaccca cctcctccag cttgggtggc   4500

cctgccactc ctggttccaa gtctctcctt tcctggcagg tcttaaggga agattgtacc   4560

cctcaccctt tacataccca gaatcatcag tatgtcactt cctaatttct atcagtgtat   4620

ctcattattt catactgttt tactaatcct aagtctaaac agatttgctc aaaaggagac   4680

cattctattt tttaaagtac ttagtgatac acgtataagc tttgcatgga cgaattaaat   4740

aagcacattg accttttctt gtacattcag aacctgaaca tccatgtgaa aactgggtcc   4800

atttttgaga gatgtgaaac tacagtttat ttgtaataaa taaatataat ctatccgtat   4860

atgcatatat ctatatgctg tgttaagtgg taatgggtac attacagtct gtgagagatg   4920

gatcgctccc tctgtaagga acaagacgtt ctcagctgat gtcacggtag gtttagattc   4980

tgtagagtgt tccccaaccc gcaccgttct gtacctctca caccactgct tgcccgggca   5040

gtagtggctg accaataaag acctttacct gttttgtatg gcatgggaag gcaatctttg   5100

gc                                                                  5102


<210>  8446
<211>  81
<212>  PRT
<213>  Homosapiens

<400>  8446

Met Leu Gly Lys Val Leu Thr Ser Arg Ala Leu Ile Thr Asp Gly Phe 
1               5                   10                  15      


Asn Ser Leu Val Gly Gly Val Met Gly Phe Ser Ile Leu Leu Ser Ala 
            20                  25                  30          


Glu Val Phe Lys His Asp Ser Ala Val Trp Tyr Leu Asp Gly Ser Ile 
        35                  40                  45              


Gly Val Leu Ile Gly Leu Thr Ile Phe Ala Tyr Gly Val Lys Leu Leu 
    50                  55                  60                  


Ile Asp Met Val Pro Arg Val Arg Gln Thr Arg His Tyr Glu Met Phe 
65                  70                  75                  80  


Glu 
    


<210>  8447
<211>  1084
<212>  DNA
<213>  Homosapiens

<400>  8447
gtgcaagtct tcgtgtggac gtatgccttc atttctcttg gagtagaatt gctgaatcct     60

atggacgatt tcctgttcag tgtctccatt ttaagtggga ttctttgcag catcctggcc    120

gtgttgaagt tcatgctggg gaaggttctg accagtagag cactcataac agatgggttt    180

aactccctcg tgggtggcgt gatgggcttc tccattcttc tgagcgcgga agtgttcaag    240

catgactcgg cggtctggta cctggacggc agcataggcg ttctgatcgg cctcaccata    300

tttgcctatg gggagtttcc acataggcaa agggtgccaa tatttaactg aacatctggt    360

ttctttttgg aagttttggt tctcatgggt aggatgagat ctttggcaga aaggtcttcg    420

gtggtgctct gagcctgcgc tgcataggac tgagcagacc cacctcctcc agcttgggtg    480

gccctgccac tcctggttcc aagtctctcc tttcctggca ggtcttaagg gaagattgta    540

cccctcaccc tttacatacc cagaatcatc agtatgtcac ttcctaattt ctatcagtgt    600

atctcattat ttcatactgt tttactaatc ctaagtctaa acagatttgc tcaaaaggag    660

accattctat tttttaaagt acttagtgat acacgtataa gctttgcatg gacgaattaa    720

ataagcacat tgaccttttc ttgtacattc agaacctgaa catccatgtg aaaactgggt    780

ccatttttga gagatgtgaa actacagttt atttgtaata aataaatata atctatccgt    840

atatgcatat atctatatgc tgtgttaagt ggtaatgggt acattacagt ctgtgagaga    900

tggatcgctc cctctgtaag gaacaagacg ttctcagctg atgtcacggt aggtttagat    960

tctgtagagt gttccccaac ccgcaccgtt ctgtacctct cacaccactg cttgcccggg   1020

cagtagtggc tgaccaataa agacctttac ctgttttgta tggcatggga aggcaatctt   1080

tggc                                                                1084


<210>  8448
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  8448

Met Asp Asp Phe Leu Phe Ser Val Ser Ile Leu Ser Gly Ile Leu Cys 
1               5                   10                  15      


Ser Ile Leu Ala Val Leu Lys Phe Met Leu Gly Lys Val Leu Thr Ser 
            20                  25                  30          


Arg Ala Leu Ile Thr Asp Gly Phe Asn Ser Leu Val Gly Gly Val Met 
        35                  40                  45              


Gly Phe Ser Ile Leu Leu Ser Ala Glu Val Phe Lys His Asp Ser Ala 
    50                  55                  60                  


Val Trp Tyr Leu Asp Gly Ser Ile Gly Val Leu Ile Gly Leu Thr Ile 
65                  70                  75                  80  


Phe Ala Tyr Gly Glu Phe Pro His Arg Gln Arg Val Pro Ile Phe Asn 
                85                  90                  95      


<210>  8449
<211>  1366
<212>  DNA
<213>  Homosapiens

<400>  8449
gagaacactg gtgtgcaagt cttcgtgtgg acgtatgcct tcatttctct tggagtagaa     60

ttgctgaatc ctatggacga tttcctgttc agtgtctcca ttttaagtgg gattctttgc    120

agcatcctgg ccgtgttgaa gttcatgctg gggaaggttc tgaccagtag agcactcata    180

acagatgggt ttaactccct cgtgggtggc gtgatgggct tctccattct tctgagcgcg    240

gaagtgttca agcatgactc ggcggtctgg tacctggacg gcagcatagg cgttctgatc    300

ggcctcacca tatttgccta tggggtcaaa ctcctcatcg acatggtgcc gagggtgagg    360

cagacacgtc actacgagat gtttgagtga agggggccag catccgcatg agaccatcga    420

gatgaggagt ttccacatag gcaaagggtg ccaatattta actgaacatc tggtttcttt    480

ttggaagttt tctttcacat ggtttgtcat tacaagacaa ggtctgccca gccaggtgga    540

tctaccttgc ccccatcacc tgccgccccc atcaaacatg ttgggacaat gcccatagga    600

atggacctcc ttccccgtct ccagctggga ctggcgtttt ttagtctctg gagtatgatg    660

gttctcatgg gtaggatgag atctttggca gaaaggtctt cggtggtgct ctgagcctgc    720

gctgcatagg actgagcaga cccacctcct ccagcttggg tggccctgcc actcctggtt    780

ccaagtctct cctttcctgg caggtcttaa gggaagattg tacccctcac cctttacata    840

cccagaatca tcagtatgtc acttcctaat ttctatcagt gtatctcatt atttcatact    900

gttttactaa tcctaagtct aaacagattt gctcaaaagg agaccattct attttttaaa    960

gtacttagtg atacacgtat aagctttgca tggacgaatt aaataagcac attgaccttt   1020

tcttgtacat tcagaacctg aacatccatg tgaaaactgg gtccattttt gagagatgtg   1080

aaactacagt ttatttgtaa taaataaata taatctatcc gtatatgcat atatctatat   1140

gctgtgttaa gtggtaatgg gtacattaca gtctgtgaga gatggatcgc tccctctgta   1200

aggaacaaga cgttctcagc tgatgtcacg gtaggtttag attctgtaga gtgttcccca   1260

acccgcaccg ttctgtacct ctcacaccac tgcttgcccg ggcagtagtg gctgaccaat   1320

aaagaccttt acctgttttg tatggcatgg gaaggcaatc tttggc                  1366


<210>  8450
<211>  105
<212>  PRT
<213>  Homosapiens

<400>  8450

Met Asp Asp Phe Leu Phe Ser Val Ser Ile Leu Ser Gly Ile Leu Cys 
1               5                   10                  15      


Ser Ile Leu Ala Val Leu Lys Phe Met Leu Gly Lys Val Leu Thr Ser 
            20                  25                  30          


Arg Ala Leu Ile Thr Asp Gly Phe Asn Ser Leu Val Gly Gly Val Met 
        35                  40                  45              


Gly Phe Ser Ile Leu Leu Ser Ala Glu Val Phe Lys His Asp Ser Ala 
    50                  55                  60                  


Val Trp Tyr Leu Asp Gly Ser Ile Gly Val Leu Ile Gly Leu Thr Ile 
65                  70                  75                  80  


Phe Ala Tyr Gly Val Lys Leu Leu Ile Asp Met Val Pro Arg Val Arg 
                85                  90                  95      


Gln Thr Arg His Tyr Glu Met Phe Glu 
            100                 105 


<210>  8451
<211>  1743
<212>  DNA
<213>  Homosapiens

<400>  8451
aggaggaggt tccaagatac ccaaatagga acagctccag tctgcagctc ccagcatgag     60

caacacagaa gacagaaaca ccaaggaagg ctctggtcta aaccttgccc tcactcctgt    120

cttctggctc ctgaccaccc tggtgtcttc ccctgtggcc ctgcaaggca tatcatgctt    180

cctgtctcta ggacctgctt actagaaagc agcacccgcc tgaaacctca cgaagcccag    240

aactacagga agaaggcatt gtgggtgtcc tggttctcca tcattgtcac cctggccctc    300

gcggtggctg cctttactgt ctccgttatg aggtacagcg cctctgcttt tgggtttgca    360

tttgatgcca tcctggacgt cctgtcatcg gcgattgtcc tgtggcgtta cagcaacgcg    420

gccgctgtgc actctgccca tagggagtac atgacgattt cctgttcagt gtctccattt    480

taagtgggat tctttgcagc atcctggccg tgttgaagtt catgctgggg aaggttctga    540

ccagtagagc actcataaca gatgggttta actccctcgt gggtggcgtg atgggcttct    600

ccattcttct gagcgcggaa gtgttcaagc atgactcggc ggtctggtac ctggacggca    660

gcataggcgt tctgatcggc ctcaccatat ttgcctatgg ggtcaaactc ctcatcgaca    720

tggtgccgag ggtgaggcag acacgtcact acgagatgtt tgagtgaagg gggccagcat    780

ccgcatgaga ccatcgagat gaggagtttc cacataggca aagggtgcca atatttaact    840

gaacatctgg tttctttttg gaagttttct ttcacatggt ttgtcattac aagacaaggt    900

ctgcccagcc aggtggatct accttgcccc catcacctgc cgcccccatc aaacatgttg    960

ggacaatgcc cataggaatg gacctccttc cccgtctcca gctgggactg gcgtttttta   1020

gtctctggag tatgatggtt ctcatgggta ggatgagatc tttggcagaa aggtcttcgg   1080

tggtgctctg agcctgcgct gcataggact gagcagaccc acctcctcca gcttgggtgg   1140

ccctgccact cctggttcca agtctctcct ttcctggcag gtcttaaggg aagattgtac   1200

ccctcaccct ttacataccc agaatcatca gtatgtcact tcctaatttc tatcagtgta   1260

tctcattatt tcatactgtt ttactaatcc taagtctaaa cagatttgct caaaaggaga   1320

ccattctatt ttttaaagta cttagtgata cacgtataag ctttgcatgg acgaattaaa   1380

taagcacatt gaccttttct tgtacattca gaacctgaac atccatgtga aaactgggtc   1440

catttttgag agatgtgaaa ctacagttta tttgtaataa ataaatataa tctatccgta   1500

tatgcatata tctatatgct gtgttaagtg gtaatgggta cattacagtc tgtgagagat   1560

ggatcgctcc ctctgtaagg aacaagacgt tctcagctga tgtcacggta ggtttagatt   1620

ctgtagagtg ttccccaacc cgcaccgttc tgtacctctc acaccactgc ttgcccgggc   1680

agtagtggct gaccaataaa gacctttacc tgttttgtat ggcatgggaa ggcaatcttt   1740

ggc                                                                 1743


<210>  8452
<211>  102
<212>  PRT
<213>  Homosapiens

<400>  8452

Met Leu Pro Val Ser Arg Thr Cys Leu Leu Glu Ser Ser Thr Arg Leu 
1               5                   10                  15      


Lys Pro His Glu Ala Gln Asn Tyr Arg Lys Lys Ala Leu Trp Val Ser 
            20                  25                  30          


Trp Phe Ser Ile Ile Val Thr Leu Ala Leu Ala Val Ala Ala Phe Thr 
        35                  40                  45              


Val Ser Val Met Arg Tyr Ser Ala Ser Ala Phe Gly Phe Ala Phe Asp 
    50                  55                  60                  


Ala Ile Leu Asp Val Leu Ser Ser Ala Ile Val Leu Trp Arg Tyr Ser 
65                  70                  75                  80  


Asn Ala Ala Ala Val His Ser Ala His Arg Glu Tyr Met Thr Ile Ser 
                85                  90                  95      


Cys Ser Val Ser Pro Phe 
            100         


<210>  8453
<211>  840
<212>  DNA
<213>  Homosapiens

<400>  8453
gtgcaagtct tcgtgtggac gtatgccttc atttctcttg gagtagaatt gctgaatcct     60

atggacgatt tcctgttcag tgtctccatt ttaagtggga ttctttgcag catcctggcc    120

gtgttgaagt tcatgctggg gaaggttctg accagtagag cactcataac agatgggttt    180

aactccctcg tgggtggcgt gatgggcttc tccattcttc tgagcgcgga agtgttcaag    240

catgactcgg cggtctggta cctggacggc agcataggcg ttctgatcgg cctcaccata    300

tttgcctatg gggagtttcc acataggcaa agggtgccaa tatttaactg aacatctggt    360

ttctttttgg aagttttggt tctcatgggt aggatgagat ctttggcaga aaggtcttcg    420

gtggtgctct gagcctgcgc tgcataggac tgagcagacc cacctcctcc agcttgggtg    480

gccctgccac tcctggttcc aagtctctcc tttcctggca ggtcttaagg gaagattgta    540

cccctcaccc tttacatacc cagaatcatc agtatgtcac ttcctaattt ctatcagtgt    600

atctcattat ttcatactgt tttactaatc ctaagtctaa acagatttgc tcaaaaggag    660

accattctat tttttaaagt acttagtgat acacgtataa gctttgcatg gacgaattaa    720

ataagcacat tgaccttttc ttgtacattc agaacctgaa catccatgtg aaaactgggt    780

ccatttttga gagatgtgaa actacagttt atttgtaata aataaatata atctatccgt    840


<210>  8454
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  8454

Met Asp Asp Phe Leu Phe Ser Val Ser Ile Leu Ser Gly Ile Leu Cys 
1               5                   10                  15      


Ser Ile Leu Ala Val Leu Lys Phe Met Leu Gly Lys Val Leu Thr Ser 
            20                  25                  30          


Arg Ala Leu Ile Thr Asp Gly Phe Asn Ser Leu Val Gly Gly Val Met 
        35                  40                  45              


Gly Phe Ser Ile Leu Leu Ser Ala Glu Val Phe Lys His Asp Ser Ala 
    50                  55                  60                  


Val Trp Tyr Leu Asp Gly Ser Ile Gly Val Leu Ile Gly Leu Thr Ile 
65                  70                  75                  80  


Phe Ala Tyr Gly Glu Phe Pro His Arg Gln Arg Val Pro Ile Phe Asn 
                85                  90                  95      


<210>  8455
<211>  1122
<212>  DNA
<213>  Homosapiens

<400>  8455
gagaacactg gtgtgcaagt cttcgtgtgg acgtatgcct tcatttctct tggagtagaa     60

ttgctgaatc ctatggacga tttcctgttc agtgtctcca ttttaagtgg gattctttgc    120

agcatcctgg ccgtgttgaa gttcatgctg gggaaggttc tgaccagtag agcactcata    180

acagatgggt ttaactccct cgtgggtggc gtgatgggct tctccattct tctgagcgcg    240

gaagtgttca agcatgactc ggcggtctgg tacctggacg gcagcatagg cgttctgatc    300

ggcctcacca tatttgccta tggggtcaaa ctcctcatcg acatggtgcc gagggtgagg    360

cagacacgtc actacgagat gtttgagtga agggggccag catccgcatg agaccatcga    420

gatgaggagt ttccacatag gcaaagggtg ccaatattta actgaacatc tggtttcttt    480

ttggaagttt tctttcacat ggtttgtcat tacaagacaa ggtctgccca gccaggtgga    540

tctaccttgc ccccatcacc tgccgccccc atcaaacatg ttgggacaat gcccatagga    600

atggacctcc ttccccgtct ccagctggga ctggcgtttt ttagtctctg gagtatgatg    660

gttctcatgg gtaggatgag atctttggca gaaaggtctt cggtggtgct ctgagcctgc    720

gctgcatagg actgagcaga cccacctcct ccagcttggg tggccctgcc actcctggtt    780

ccaagtctct cctttcctgg caggtcttaa gggaagattg tacccctcac cctttacata    840

cccagaatca tcagtatgtc acttcctaat ttctatcagt gtatctcatt atttcatact    900

gttttactaa tcctaagtct aaacagattt gctcaaaagg agaccattct attttttaaa    960

gtacttagtg atacacgtat aagctttgca tggacgaatt aaataagcac attgaccttt   1020

tcttgtacat tcagaacctg aacatccatg tgaaaactgg gtccattttt gagagatgtg   1080

aaactacagt ttatttgtaa taaataaata taatctatcc gt                      1122


<210>  8456
<211>  105
<212>  PRT
<213>  Homosapiens

<400>  8456

Met Asp Asp Phe Leu Phe Ser Val Ser Ile Leu Ser Gly Ile Leu Cys 
1               5                   10                  15      


Ser Ile Leu Ala Val Leu Lys Phe Met Leu Gly Lys Val Leu Thr Ser 
            20                  25                  30          


Arg Ala Leu Ile Thr Asp Gly Phe Asn Ser Leu Val Gly Gly Val Met 
        35                  40                  45              


Gly Phe Ser Ile Leu Leu Ser Ala Glu Val Phe Lys His Asp Ser Ala 
    50                  55                  60                  


Val Trp Tyr Leu Asp Gly Ser Ile Gly Val Leu Ile Gly Leu Thr Ile 
65                  70                  75                  80  


Phe Ala Tyr Gly Val Lys Leu Leu Ile Asp Met Val Pro Arg Val Arg 
                85                  90                  95      


Gln Thr Arg His Tyr Glu Met Phe Glu 
            100                 105 


<210>  8457
<211>  1668
<212>  DNA
<213>  Homosapiens

<400>  8457
cgcacttctg actcgagtcc ccgccgcgct tgtcgtcgcc gccgccggga tccgcagccc     60

cgcgccatgg agccggccgc gggcatccag cgccgcagct cccaggggcc caccgtcccg    120

ccgccgcccc ggggccacgc gccaccggct gccgcccccg gcccggcccc gctgagctcc    180

ccggtgcgcg agccgcccca gctggaggag gagcggcagg tgcggatcag cgagagcggc    240

cagttcagcg acgggctgga ggaccgaggc ttactagaaa gcagcacccg cctgaaacct    300

cacgaagccc agaactacag gaagaaggca ttgtgggtgt cctggttctc catcattgtc    360

accctggccc tcgcggtggc tgcctttact gtctccgtta tgaggtacag cgcctctgct    420

tttgggtttg catttgatgc catcctggac gtcctgtcat cggcgattgt cctgtggcgt    480

tacagcaacg cggccgctgt gcactctgcc catagggagt acatagcctg tgtcatcttg    540

ggggtgatat tccttctgtc atccatatgt atagtggtca aagccatcca tgacctctca    600

actaggctgc tcccagaagt ggacgatttc ctgttcagtg tctccatttt aagtgggatt    660

ctttgcagca tcctggccgt gttgaagttc atgctgggga aggttctgac cagtagagca    720

ctcataacag atgggtttaa ctccctcgtg ggtggcgtga tgggcttctc cattcttctg    780

agcgcggaag tgttcaagca tgactcggcg gtctggtacc tggacggcag cataggcgtt    840

ctgatcggcc tcaccatatt tgcctatggg gtcaaactcc tcatcgacat ggtgccgagg    900

gtgaggcaga cacgtcacta cgagatgttt gagtgaaggg ggccagcatc cgcatgagac    960

catcgagatg aggagtttcc acataggcaa agggtgccaa tatttaactg aacatctggt   1020

ttctttttgg aagttttctt tcacatggtt tgtcattaca agacaaggtc tgcccagcca   1080

ggtggatcta ccttgccccc atcacctgcc gcccccatca aacatgttgg gacaatgccc   1140

ataggaatgg acctccttcc ccgtctccag ctgggactgg cgttttttag tctctggagt   1200

atgatggttc tcatgggtag gatgagatct ttggcagaaa ggtcttcggt ggtgctctga   1260

gcctgcgctg cataggactg agcagaccca cctcctccag cttgggtggc cctgccactc   1320

ctggttccaa gtctctcctt tcctggcagg tcttaaggga agattgtacc cctcaccctt   1380

tacataccca gaatcatcag tatgtcactt cctaatttct atcagtgtat ctcattattt   1440

catactgttt tactaatcct aagtctaaac agatttgctc aaaaggagac cattctattt   1500

tttaaagtac ttagtgatac acgtataagc tttgcatgga cgaattaaat aagcacattg   1560

accttttctt gtacattcag aacctgaaca tccatgtgaa aactgggtcc atttttgaga   1620

gatgtgaaac tacagtttat ttgtaataaa taaatataat ctatccgt                1668


<210>  8458
<211>  289
<212>  PRT
<213>  Homosapiens

<400>  8458

Met Glu Pro Ala Ala Gly Ile Gln Arg Arg Ser Ser Gln Gly Pro Thr 
1               5                   10                  15      


Val Pro Pro Pro Pro Arg Gly His Ala Pro Pro Ala Ala Ala Pro Gly 
            20                  25                  30          


Pro Ala Pro Leu Ser Ser Pro Val Arg Glu Pro Pro Gln Leu Glu Glu 
        35                  40                  45              


Glu Arg Gln Val Arg Ile Ser Glu Ser Gly Gln Phe Ser Asp Gly Leu 
    50                  55                  60                  


Glu Asp Arg Gly Leu Leu Glu Ser Ser Thr Arg Leu Lys Pro His Glu 
65                  70                  75                  80  


Ala Gln Asn Tyr Arg Lys Lys Ala Leu Trp Val Ser Trp Phe Ser Ile 
                85                  90                  95      


Ile Val Thr Leu Ala Leu Ala Val Ala Ala Phe Thr Val Ser Val Met 
            100                 105                 110         


Arg Tyr Ser Ala Ser Ala Phe Gly Phe Ala Phe Asp Ala Ile Leu Asp 
        115                 120                 125             


Val Leu Ser Ser Ala Ile Val Leu Trp Arg Tyr Ser Asn Ala Ala Ala 
    130                 135                 140                 


Val His Ser Ala His Arg Glu Tyr Ile Ala Cys Val Ile Leu Gly Val 
145                 150                 155                 160 


Ile Phe Leu Leu Ser Ser Ile Cys Ile Val Val Lys Ala Ile His Asp 
                165                 170                 175     


Leu Ser Thr Arg Leu Leu Pro Glu Val Asp Asp Phe Leu Phe Ser Val 
            180                 185                 190         


Ser Ile Leu Ser Gly Ile Leu Cys Ser Ile Leu Ala Val Leu Lys Phe 
        195                 200                 205             


Met Leu Gly Lys Val Leu Thr Ser Arg Ala Leu Ile Thr Asp Gly Phe 
    210                 215                 220                 


Asn Ser Leu Val Gly Gly Val Met Gly Phe Ser Ile Leu Leu Ser Ala 
225                 230                 235                 240 


Glu Val Phe Lys His Asp Ser Ala Val Trp Tyr Leu Asp Gly Ser Ile 
                245                 250                 255     


Gly Val Leu Ile Gly Leu Thr Ile Phe Ala Tyr Gly Val Lys Leu Leu 
            260                 265                 270         


Ile Asp Met Val Pro Arg Val Arg Gln Thr Arg His Tyr Glu Met Phe 
        275                 280                 285             


Glu 
    


<210>  8459
<211>  5911
<212>  DNA
<213>  Homosapiens

<400>  8459
atgaggactg ctgacgaagt ctgtcatact ctggggattg gtaagaacct ggagaaagag     60

aagaaaagag tgtgctctgt gaagggggga cagttgggac aattatggcc aggtccgtgg    120

ggaaggtgta caggagactg tggtcccgga ggagtccaga gtcgggcagt gtggtgtttt    180

catgttgacg ggtggacaag tcacctgtct aactgtggtg agagcaacag gcctccaaag    240

gaaagaagtt gtttccgagt ttgtgactgg cacagtgacc tctttcagtg ggaggtttct    300

gactggcacc actgtgtgct tgttccttac gctcgcggtg aagtcaagcc tcggactgca    360

gagtgtgtga cggctcagca tggactgcag caccggatgg tgcgctgcat tcagaagctg    420

aaccgaactg tggttgcaaa tgaaatatgc gaacactttg cccttcagcc tcctacagaa    480

caggcttgcc tcattccttg tccccgggat tgtgtagtat ctgagttctt accatggtcc    540

aactgtagca agggatgtgg gaagaaattg cagcatagaa ctcgcgcggt catagctccc    600

cctctctttg gtggtttgca atgtccaaat ctgactgagt caagagcctg tgatgctccc    660

atttcctgtc ctcttgggga agaggaatat acatttagcc ttaaggttgg accatggagt    720

aaatgcagac tgcctcatct taaagaaatt aatccaagcg gaagaactgt tctggatttt    780

aactctgatt caaatgagcg agtcaccttt aaacatcaaa gttacaaagc acatcatcat    840

tcgaagtctt gggcaataga gataggttat caaacccggc aggtttcgtg tacaagaagt    900

gatggacaaa atgctatgtt aagcctttgc cttcaagatt ccttcccatt gactgttcag    960

tcctgcatca tgcccaaaga ctgtgaaacc tcccagtggt cctcctggag cccctgctcc   1020

aagacatgcc gttcagggag tctcttgcca ggatttagga gcaggagccg gaacgtgaag   1080

cacatggcta ttggaggtgg aaaggagtgt cctgaacttc ttgagaaaga ggcctgcatt   1140

gttgaaggag aacttctgca gcaatgtccc aggtattcct ggagaacttc tgaatggaaa   1200

gaatgccaag tctctctcct cctcgagcag caggatcccc actggcatgt gacgggaccc   1260

gtgtgtggcg gtgggatcca gacccgggag gtgtactgtg cccagagcgt accagcagct   1320

gccgcactga gggccaagga agtctctaga cctgtggaaa aggcattatg tgtgggaccc   1380

gccccgttgc cctctcagct ctgcaatatc ccttgctcta cggactgcat agtatcttcc   1440

tggtcagcct ggggcctgtg catccatgaa aactgtcatg atcctcaggg gaaaaaagga   1500

tttagaacga ggcagcgcca tgtcctcatg gaatctacag ggcctgcagg gcattgccct   1560

catttggtgg agtctgttcc ttgtgaggat ccaatgtgct accgatggct ggcatcagaa   1620

gggatctgtt tccctgatca tggaaaatgt ggcctgggac atcgtattct gaaggccgtc   1680

tgccagaatg accgcggaga agatgtatca gggagtcttt gcccagttcc ccctcctcct   1740

gagaggaagt cttgtgaaat tccctgccga atggactgtg tgctgagcga gtggacggag   1800

tggtcatcct gttcccagtc ctgttcaaat aaaaactcag atgggaaaca gaccaggtca   1860

agaactatcc tggcactggc tggggaaggt ggaaagccat gtccccctag tcaggctctc   1920

caagagcatc gtttgtgtaa tgaccattcc tgtatgcagc ttcactggga gacatcgcct   1980

tggggccctt gttctgagga cacattggta actgccctta atgcaaccat tggctggaat   2040

ggagaagcca cgtgtggtgt aggcattcag actcggagag tcttctgtgt caagagtcac   2100

gtgggacaag taatgaccaa aagatgtcca gattctactc gacctgaaac tgtgcgcccc   2160

tgttttctcc catgcaaaaa agactgtatt gtgactgctt tcagtgagtg gacaccctgc   2220

ccaaggatgt gccaagcagg aaatgccaca gtaaaacagt ctcgatacag aatcatcatc   2280

caagaagcag ccaatggagg ccaggaatgc ccagatacct tatatgagga gagagagtgt   2340

gaagatgttt ccttgtgtcc tgtatatcgg tggaagccac agaaatggag cccttgcatc   2400

ttagtgccag agtctgtctg gcagggaata acgggcagca gtgaagcctg tggaaagggg   2460

ttacaaacaa gagctgtctc atgcatctct gatgacaacc ggtcagcaga aatgatggaa   2520

tgcctcaagc agacaaacgg catgcctctc cttgtgcaag aatgcacagt cccatgtcga   2580

gaagactgca ccttcactgc ttggtccaag tttacgccct gctccacgaa ctgtgaagcc   2640

acaaaaagta ggcggcgaca gctcacaggg aaaagcagaa agaaggagaa atgccaggat   2700

tctgaccttt accctctagt ggagacagaa ctatgtcctt gtgatgaatt tatatcccaa   2760

ccttatggaa actggtcaga ttgcattctt ccagaaggca gaagggagcc tcaccgagga   2820

ctgcgggtac aagcagacag caaagaatgt ggagaaggcc tgcgctttcg agcagtagcc   2880

tgttctgata aaaatggaag acctgttgac ccctccttct gcagcagctc tggttacatt   2940

caagaaaaat gtgtcattcc ctgcccattt gattgcaagt taagcgattg gtctagttgg   3000

gggtcttgca gttcatcttg tggaattgga gtgagaattc gatccaaatg gctaaaagaa   3060

aaaccttaca atggaggacg accatgtccc aaactggatc tcaagaatca ggtaaagtac   3120

atgaggcagt cccatgttac agtgagtgca atcagtattc ctgggttgta gaacactggt   3180

cttcatgcaa aatcaacaat gagctgaggt ccctgcgctg tggaggagga acacaatcta   3240

ggaaaatcag atgtgtgaat actgcggatg gtgaaggtgg agcagtggat agcaacctgt   3300

gcaaccagga tgaaattccc ccagaaaccc agtcctgttc tcttatgtgt cccaatgagt   3360

gtgtcatgtc tgagtgggga ctttggagca aatgcccaca gtcatgcgat ccccacacaa   3420

tgcagagaag aactcgccac ctgctaagac catcactgaa ctcaaggact tgtgctgaag   3480

actcacaggt gcagccttgc ctcctgaatg aaaattgctt ccagttccag tacaatctaa   3540

cagagtggag cacatgccag ctgagtgaaa acgcaccctg tggtcaaggc gtcaggaccc   3600

gcctgctaag ctgtgtgtgc agtgatggca agccagtcag catggaccaa tgtgagcagc   3660

ataatttgga gaagccccag agaatgagca ttccctgctt ggtggaatgc gtggtcaact   3720

gtcagctctc agggtggacg gcttggacag agtgttcaca gacctgtggc catggaggtc   3780

gaatgagccg gactcgattt atcattatgc caacccaagg agaaggacgg ccatgcccca   3840

cagagcttac ccaggagaaa acctgcccag tgaccccctg ctacagctgg gtccttggca   3900

actggtctgc atgtaaattg gagggtggag actgtgggga aggagttcag atccgcagcc   3960

tttcctgcat ggtccacagt ggttcaatat ctcatgcagc tggacgtgtc gaggatgcac   4020

tgtgtggaga aatgcccttt caggacagca tcctgaagca gctgtgttct gtgccttgcc   4080

caggagactg ccatttaaca gaatggtcag agtggagcac atgtgaatta acctgcattg   4140

atggaagaag ctttgagact gtgggccgcc agtctagatc aaggactttt ataattcagt   4200

cttttgagaa ccaagacagc tgcccccaac aggttctaga aacacgccct tgtacaggag   4260

gcaaatgtta tcactacaca tggaaagcaa gtctttggaa caataacgaa cgaactgtat   4320

ggtgccagcg ttcagatggc gttaatgtca caggaggctg ctcccctcag gcccgtcctg   4380

ctgccattcg gcagtgcatt ccagcctgca gaaaaccttt ctcctactgt acacagggtg   4440

gagtctgtgg ttgtgagaag ggctatacag agataatgaa atcaaatggt ttcctggatt   4500

actgcatgaa agtaccaggc tcagaggata aaaaagctga tgtgaaaaac ctttctggga   4560

aaaacagacc tgtgaattca aaaatacatg atatttttaa aggatggtct cttcaaccac   4620

ttgatccaga tggccgagta aaaatttggg tttatggcgt ttcaggtggc gcttttctca   4680

tcatgatttt cctaatattt acttcctacc ttgtttgcaa gaagccaaaa ccacatcaaa   4740

gcacacctcc ccaacagaag cctctgacct tagcctacga tggagactta gacatgtaat   4800

ctgaaaaaga aatccaaatg tagacatcaa ctgccttaac cgctttctct tttgtagctc   4860

tcagacttct cagttttttg aggaatctca agatgtgata tattgggcag aatacaaata   4920

ttgcaaaagt aatattgcct caacttcatt tggacatgga gtcaaggatt attaggtctg   4980

ccattttgtt ttcaagttgt ttgtgggtgt gttttatttt tttggttttc ccaagggacc   5040

tgaaaaccct tctcttcctg tttggaactg ggaggaagaa aacatgatgg aattcccaca   5100

gacttgagta aacttgatct tcagcagcat aatgacaatc cagaggaaaa tacagtcaag   5160

gcatttactc taaatgacga gtctgacact gcattgttac gcactatatt agtgcaaagt   5220

ctttattctt cccatacttc aacactgagt tttctagagt ttactttggt ttaaagactt   5280

tcaaattgga ttgcctattt ttcatgaaca cagagagaat ggattaccat ttcagaaatt   5340

ctctgagttt ttaaccttta aatattgtat tttgttttgt agccagggga tgatggcgct   5400

tcatgggttg cagctactga aaatagcagc gtgtgtgtaa ttgctggact agatgaaagc   5460

taggtcattt ctgaagggaa tgtgtactga atgttagagt gtacaaatga aatatgtggt   5520

taaattggag aatgaggtag attatttgat tactaaaact gtattttaac aaaaacttat   5580

ccatgtagat atagcattaa ccacacacag ttgtaattca gtttaatgat gacaaactct   5640

gcttttgtaa tttcaatttt cttatctgaa tatttataaa ttcttctttc aaatttaatt   5700

atctgacctc atttaatata catcaaacac cgatcctgtt tgtacaaagt cttgctttta   5760

taaggtttca ataatatcta aaacaacaca ttaaaaagct gagaccattt tatgaagata   5820

attgtttgta atcataggtg ttgaaagtaa aaaggtgcca tcttgtggta ttgacttgta   5880

tttataacaa ataaactgct caagagactg c                                  5911


<210>  8460
<211>  1056
<212>  PRT
<213>  Homosapiens

<400>  8460

Met Arg Thr Ala Asp Glu Val Cys His Thr Leu Gly Ile Gly Lys Asn 
1               5                   10                  15      


Leu Glu Lys Glu Lys Lys Arg Val Cys Ser Val Lys Gly Gly Gln Leu 
            20                  25                  30          


Gly Gln Leu Trp Pro Gly Pro Trp Gly Arg Cys Thr Gly Asp Cys Gly 
        35                  40                  45              


Pro Gly Gly Val Gln Ser Arg Ala Val Trp Cys Phe His Val Asp Gly 
    50                  55                  60                  


Trp Thr Ser His Leu Ser Asn Cys Gly Glu Ser Asn Arg Pro Pro Lys 
65                  70                  75                  80  


Glu Arg Ser Cys Phe Arg Val Cys Asp Trp His Ser Asp Leu Phe Gln 
                85                  90                  95      


Trp Glu Val Ser Asp Trp His His Cys Val Leu Val Pro Tyr Ala Arg 
            100                 105                 110         


Gly Glu Val Lys Pro Arg Thr Ala Glu Cys Val Thr Ala Gln His Gly 
        115                 120                 125             


Leu Gln His Arg Met Val Arg Cys Ile Gln Lys Leu Asn Arg Thr Val 
    130                 135                 140                 


Val Ala Asn Glu Ile Cys Glu His Phe Ala Leu Gln Pro Pro Thr Glu 
145                 150                 155                 160 


Gln Ala Cys Leu Ile Pro Cys Pro Arg Asp Cys Val Val Ser Glu Phe 
                165                 170                 175     


Leu Pro Trp Ser Asn Cys Ser Lys Gly Cys Gly Lys Lys Leu Gln His 
            180                 185                 190         


Arg Thr Arg Ala Val Ile Ala Pro Pro Leu Phe Gly Gly Leu Gln Cys 
        195                 200                 205             


Pro Asn Leu Thr Glu Ser Arg Ala Cys Asp Ala Pro Ile Ser Cys Pro 
    210                 215                 220                 


Leu Gly Glu Glu Glu Tyr Thr Phe Ser Leu Lys Val Gly Pro Trp Ser 
225                 230                 235                 240 


Lys Cys Arg Leu Pro His Leu Lys Glu Ile Asn Pro Ser Gly Arg Thr 
                245                 250                 255     


Val Leu Asp Phe Asn Ser Asp Ser Asn Glu Arg Val Thr Phe Lys His 
            260                 265                 270         


Gln Ser Tyr Lys Ala His His His Ser Lys Ser Trp Ala Ile Glu Ile 
        275                 280                 285             


Gly Tyr Gln Thr Arg Gln Val Ser Cys Thr Arg Ser Asp Gly Gln Asn 
    290                 295                 300                 


Ala Met Leu Ser Leu Cys Leu Gln Asp Ser Phe Pro Leu Thr Val Gln 
305                 310                 315                 320 


Ser Cys Ile Met Pro Lys Asp Cys Glu Thr Ser Gln Trp Ser Ser Trp 
                325                 330                 335     


Ser Pro Cys Ser Lys Thr Cys Arg Ser Gly Ser Leu Leu Pro Gly Phe 
            340                 345                 350         


Arg Ser Arg Ser Arg Asn Val Lys His Met Ala Ile Gly Gly Gly Lys 
        355                 360                 365             


Glu Cys Pro Glu Leu Leu Glu Lys Glu Ala Cys Ile Val Glu Gly Glu 
    370                 375                 380                 


Leu Leu Gln Gln Cys Pro Arg Tyr Ser Trp Arg Thr Ser Glu Trp Lys 
385                 390                 395                 400 


Glu Cys Gln Val Ser Leu Leu Leu Glu Gln Gln Asp Pro His Trp His 
                405                 410                 415     


Val Thr Gly Pro Val Cys Gly Gly Gly Ile Gln Thr Arg Glu Val Tyr 
            420                 425                 430         


Cys Ala Gln Ser Val Pro Ala Ala Ala Ala Leu Arg Ala Lys Glu Val 
        435                 440                 445             


Ser Arg Pro Val Glu Lys Ala Leu Cys Val Gly Pro Ala Pro Leu Pro 
    450                 455                 460                 


Ser Gln Leu Cys Asn Ile Pro Cys Ser Thr Asp Cys Ile Val Ser Ser 
465                 470                 475                 480 


Trp Ser Ala Trp Gly Leu Cys Ile His Glu Asn Cys His Asp Pro Gln 
                485                 490                 495     


Gly Lys Lys Gly Phe Arg Thr Arg Gln Arg His Val Leu Met Glu Ser 
            500                 505                 510         


Thr Gly Pro Ala Gly His Cys Pro His Leu Val Glu Ser Val Pro Cys 
        515                 520                 525             


Glu Asp Pro Met Cys Tyr Arg Trp Leu Ala Ser Glu Gly Ile Cys Phe 
    530                 535                 540                 


Pro Asp His Gly Lys Cys Gly Leu Gly His Arg Ile Leu Lys Ala Val 
545                 550                 555                 560 


Cys Gln Asn Asp Arg Gly Glu Asp Val Ser Gly Ser Leu Cys Pro Val 
                565                 570                 575     


Pro Pro Pro Pro Glu Arg Lys Ser Cys Glu Ile Pro Cys Arg Met Asp 
            580                 585                 590         


Cys Val Leu Ser Glu Trp Thr Glu Trp Ser Ser Cys Ser Gln Ser Cys 
        595                 600                 605             


Ser Asn Lys Asn Ser Asp Gly Lys Gln Thr Arg Ser Arg Thr Ile Leu 
    610                 615                 620                 


Ala Leu Ala Gly Glu Gly Gly Lys Pro Cys Pro Pro Ser Gln Ala Leu 
625                 630                 635                 640 


Gln Glu His Arg Leu Cys Asn Asp His Ser Cys Met Gln Leu His Trp 
                645                 650                 655     


Glu Thr Ser Pro Trp Gly Pro Cys Ser Glu Asp Thr Leu Val Thr Ala 
            660                 665                 670         


Leu Asn Ala Thr Ile Gly Trp Asn Gly Glu Ala Thr Cys Gly Val Gly 
        675                 680                 685             


Ile Gln Thr Arg Arg Val Phe Cys Val Lys Ser His Val Gly Gln Val 
    690                 695                 700                 


Met Thr Lys Arg Cys Pro Asp Ser Thr Arg Pro Glu Thr Val Arg Pro 
705                 710                 715                 720 


Cys Phe Leu Pro Cys Lys Lys Asp Cys Ile Val Thr Ala Phe Ser Glu 
                725                 730                 735     


Trp Thr Pro Cys Pro Arg Met Cys Gln Ala Gly Asn Ala Thr Val Lys 
            740                 745                 750         


Gln Ser Arg Tyr Arg Ile Ile Ile Gln Glu Ala Ala Asn Gly Gly Gln 
        755                 760                 765             


Glu Cys Pro Asp Thr Leu Tyr Glu Glu Arg Glu Cys Glu Asp Val Ser 
    770                 775                 780                 


Leu Cys Pro Val Tyr Arg Trp Lys Pro Gln Lys Trp Ser Pro Cys Ile 
785                 790                 795                 800 


Leu Val Pro Glu Ser Val Trp Gln Gly Ile Thr Gly Ser Ser Glu Ala 
                805                 810                 815     


Cys Gly Lys Gly Leu Gln Thr Arg Ala Val Ser Cys Ile Ser Asp Asp 
            820                 825                 830         


Asn Arg Ser Ala Glu Met Met Glu Cys Leu Lys Gln Thr Asn Gly Met 
        835                 840                 845             


Pro Leu Leu Val Gln Glu Cys Thr Val Pro Cys Arg Glu Asp Cys Thr 
    850                 855                 860                 


Phe Thr Ala Trp Ser Lys Phe Thr Pro Cys Ser Thr Asn Cys Glu Ala 
865                 870                 875                 880 


Thr Lys Ser Arg Arg Arg Gln Leu Thr Gly Lys Ser Arg Lys Lys Glu 
                885                 890                 895     


Lys Cys Gln Asp Ser Asp Leu Tyr Pro Leu Val Glu Thr Glu Leu Cys 
            900                 905                 910         


Pro Cys Asp Glu Phe Ile Ser Gln Pro Tyr Gly Asn Trp Ser Asp Cys 
        915                 920                 925             


Ile Leu Pro Glu Gly Arg Arg Glu Pro His Arg Gly Leu Arg Val Gln 
    930                 935                 940                 


Ala Asp Ser Lys Glu Cys Gly Glu Gly Leu Arg Phe Arg Ala Val Ala 
945                 950                 955                 960 


Cys Ser Asp Lys Asn Gly Arg Pro Val Asp Pro Ser Phe Cys Ser Ser 
                965                 970                 975     


Ser Gly Tyr Ile Gln Glu Lys Cys Val Ile Pro Cys Pro Phe Asp Cys 
            980                 985                 990         


Lys Leu Ser Asp Trp Ser Ser Trp  Gly Ser Cys Ser Ser  Ser Cys Gly 
        995                 1000                 1005             


Ile Gly  Val Arg Ile Arg Ser  Lys Trp Leu Lys Glu  Lys Pro Tyr 
    1010                 1015                 1020             


Asn Gly  Gly Arg Pro Cys Pro  Lys Leu Asp Leu Lys  Asn Gln Val 
    1025                 1030                 1035             


Lys Tyr  Met Arg Gln Ser His  Val Thr Val Ser Ala  Ile Ser Ile 
    1040                 1045                 1050             


Pro Gly  Leu 
    1055     


<210>  8461
<211>  2362
<212>  DNA
<213>  Homosapiens

<400>  8461
gcctcatctt aaagaaatta atccaagcgg aagaactgtt ctggatttta actctgattc     60

aaatgagcga gtcaccttta aacatcaaag ttacaaagca catcatcatt cgaagtcttg    120

ggcaatagag ataggttatc aaacccggca ggtttcgtgt acaagaagtg atggacaaaa    180

tgctatgtta agcctttgcc ttcaagattc cttcccattg actgttcagt cctgcatcat    240

gcccaaagac tgtgaaacct cccagtggtc ctcctggagc ccctgctcca agacatgccg    300

ttcagggagt ctcttgccag gatttaggag caggagccgg aacgtgaagc acatggctat    360

tggaggtgga aaggagtgtc ctgaacttct tgagaaagag gcctgcattg ttgaaggaga    420

acttctgcag caatgtccca ggtattcctg gagaacttct gaatggaaag aatgccaagt    480

ctctctcctc ctcgagcagc aggatcccca ctggcatgtg acgggacccg tgtgtggcgg    540

tgggatccag acccgggagg tgtactgtgc ccagagcgta ccagcagctg ccgcactgag    600

ggccaaggaa gtctctagac ctgtggaaaa ggcattatgt gtgggacccg ccccgttgcc    660

ctctcagctc tgcaatatcc cttgctctac ggactgcata gtatcttcct ggtcagcctg    720

gggcctgtgc atccatgaaa actgtcatga tcctcagggg aaaaaaggat ttagaacgag    780

gcagcgccat gtcctcatgg aatctacagg gcctgcaggg cattgccctc atttggtgga    840

gtctgttcct tgtgaggatc caatgtgcta ccgatggctg gcatcagaag ggatctgttt    900

ccctgatcat ggaaaatgtg gcctgggaca tcgtattctg aaggccgtct gccagaatga    960

ccgcggagaa gatgtatcag ggagtctttg cccagttccc cctcctcctg agaggaagtc   1020

ttgtgaaatt ccctgccgaa tggactgtgt gctgagcgag tggacggagt ggtcatcctg   1080

ttcccagtcc tgttcaaata aaaactcaga tgggaaacag accaggtcaa gaactatcct   1140

ggcactggct ggggaaggtg gaaagccatg tccccctagt caggctctcc aagagcatcg   1200

tttgtgtaat gaccattcct gtatgcagct tcactgggag acatcgcctt ggggcccttg   1260

ttctgaggac acattggtaa ctgcccttaa tgcaaccatt ggctggaatg gagaagccac   1320

gtgtggtgta ggcattcaga ctcggagagt cttctgtgtc aagagtcacg tgggacaagt   1380

aatgaccaaa agatgtccag attctactcg acctgaaact gtgcgcccct gttttctccc   1440

atgcaaaaaa gactgtattg tgactgcttt cagtgagtgg acaccctgcc caaggatgtg   1500

ccaagcagga aatgccacag taaaacagtc tcgatacaga atcatcatcc aagaagcagc   1560

caatggaggc caggaatgcc cagatacctt atatgaggag agagagtgtg aagatgtttc   1620

cttgtgtcct gtatatcggt ggaagccaca gaaatggagc ccttgcatct tagtgccaga   1680

gtctgtctgg cagggaataa cgggcagcag tgaagcctgt ggaaaggggt tacaaacaag   1740

agctgtctca tgcatctctg atgacaaccg gtcagcagaa atgatggaat gcctcaagca   1800

gacaaacggc atgcctctcc ttgtgcaaga atgcacagtc ccatgtcgag aagactgcac   1860

cttcactgct tggtccaagt ttacgccctg ctccacgaac tgtgaagcca caaaaagtag   1920

gcggcgacag ctcacaggga aaagcagaaa gaaggagaaa tgccaggatt ctgaccttta   1980

ccctctagtg gagacagaac tatgtccttg tgatgaattt atatcccaac cttatggaaa   2040

ctggtcagat tgcattcttc cagaaggcag aagggagcct caccgaggac tgcgggtaca   2100

agcagacagc aaagaatgtg gagaaggcct gcgctttcga gcagtagcct gttctgataa   2160

aaatggaaga cctgttgacc cctccttctg cagcagctct ggtaaggaga tggatggaga   2220

gtaacagatg agaacactca cacacagctc gggaggtttg tctcaggtct agaattaata   2280

gctctgctct ataataattg ttttaatttt cctttgtcaa taacacattg tctctcataa   2340

aatatggaca gatgaaatgc at                                            2362


<210>  8462
<211>  679
<212>  PRT
<213>  Homosapiens

<400>  8462

Met Leu Ser Leu Cys Leu Gln Asp Ser Phe Pro Leu Thr Val Gln Ser 
1               5                   10                  15      


Cys Ile Met Pro Lys Asp Cys Glu Thr Ser Gln Trp Ser Ser Trp Ser 
            20                  25                  30          


Pro Cys Ser Lys Thr Cys Arg Ser Gly Ser Leu Leu Pro Gly Phe Arg 
        35                  40                  45              


Ser Arg Ser Arg Asn Val Lys His Met Ala Ile Gly Gly Gly Lys Glu 
    50                  55                  60                  


Cys Pro Glu Leu Leu Glu Lys Glu Ala Cys Ile Val Glu Gly Glu Leu 
65                  70                  75                  80  


Leu Gln Gln Cys Pro Arg Tyr Ser Trp Arg Thr Ser Glu Trp Lys Glu 
                85                  90                  95      


Cys Gln Val Ser Leu Leu Leu Glu Gln Gln Asp Pro His Trp His Val 
            100                 105                 110         


Thr Gly Pro Val Cys Gly Gly Gly Ile Gln Thr Arg Glu Val Tyr Cys 
        115                 120                 125             


Ala Gln Ser Val Pro Ala Ala Ala Ala Leu Arg Ala Lys Glu Val Ser 
    130                 135                 140                 


Arg Pro Val Glu Lys Ala Leu Cys Val Gly Pro Ala Pro Leu Pro Ser 
145                 150                 155                 160 


Gln Leu Cys Asn Ile Pro Cys Ser Thr Asp Cys Ile Val Ser Ser Trp 
                165                 170                 175     


Ser Ala Trp Gly Leu Cys Ile His Glu Asn Cys His Asp Pro Gln Gly 
            180                 185                 190         


Lys Lys Gly Phe Arg Thr Arg Gln Arg His Val Leu Met Glu Ser Thr 
        195                 200                 205             


Gly Pro Ala Gly His Cys Pro His Leu Val Glu Ser Val Pro Cys Glu 
    210                 215                 220                 


Asp Pro Met Cys Tyr Arg Trp Leu Ala Ser Glu Gly Ile Cys Phe Pro 
225                 230                 235                 240 


Asp His Gly Lys Cys Gly Leu Gly His Arg Ile Leu Lys Ala Val Cys 
                245                 250                 255     


Gln Asn Asp Arg Gly Glu Asp Val Ser Gly Ser Leu Cys Pro Val Pro 
            260                 265                 270         


Pro Pro Pro Glu Arg Lys Ser Cys Glu Ile Pro Cys Arg Met Asp Cys 
        275                 280                 285             


Val Leu Ser Glu Trp Thr Glu Trp Ser Ser Cys Ser Gln Ser Cys Ser 
    290                 295                 300                 


Asn Lys Asn Ser Asp Gly Lys Gln Thr Arg Ser Arg Thr Ile Leu Ala 
305                 310                 315                 320 


Leu Ala Gly Glu Gly Gly Lys Pro Cys Pro Pro Ser Gln Ala Leu Gln 
                325                 330                 335     


Glu His Arg Leu Cys Asn Asp His Ser Cys Met Gln Leu His Trp Glu 
            340                 345                 350         


Thr Ser Pro Trp Gly Pro Cys Ser Glu Asp Thr Leu Val Thr Ala Leu 
        355                 360                 365             


Asn Ala Thr Ile Gly Trp Asn Gly Glu Ala Thr Cys Gly Val Gly Ile 
    370                 375                 380                 


Gln Thr Arg Arg Val Phe Cys Val Lys Ser His Val Gly Gln Val Met 
385                 390                 395                 400 


Thr Lys Arg Cys Pro Asp Ser Thr Arg Pro Glu Thr Val Arg Pro Cys 
                405                 410                 415     


Phe Leu Pro Cys Lys Lys Asp Cys Ile Val Thr Ala Phe Ser Glu Trp 
            420                 425                 430         


Thr Pro Cys Pro Arg Met Cys Gln Ala Gly Asn Ala Thr Val Lys Gln 
        435                 440                 445             


Ser Arg Tyr Arg Ile Ile Ile Gln Glu Ala Ala Asn Gly Gly Gln Glu 
    450                 455                 460                 


Cys Pro Asp Thr Leu Tyr Glu Glu Arg Glu Cys Glu Asp Val Ser Leu 
465                 470                 475                 480 


Cys Pro Val Tyr Arg Trp Lys Pro Gln Lys Trp Ser Pro Cys Ile Leu 
                485                 490                 495     


Val Pro Glu Ser Val Trp Gln Gly Ile Thr Gly Ser Ser Glu Ala Cys 
            500                 505                 510         


Gly Lys Gly Leu Gln Thr Arg Ala Val Ser Cys Ile Ser Asp Asp Asn 
        515                 520                 525             


Arg Ser Ala Glu Met Met Glu Cys Leu Lys Gln Thr Asn Gly Met Pro 
    530                 535                 540                 


Leu Leu Val Gln Glu Cys Thr Val Pro Cys Arg Glu Asp Cys Thr Phe 
545                 550                 555                 560 


Thr Ala Trp Ser Lys Phe Thr Pro Cys Ser Thr Asn Cys Glu Ala Thr 
                565                 570                 575     


Lys Ser Arg Arg Arg Gln Leu Thr Gly Lys Ser Arg Lys Lys Glu Lys 
            580                 585                 590         


Cys Gln Asp Ser Asp Leu Tyr Pro Leu Val Glu Thr Glu Leu Cys Pro 
        595                 600                 605             


Cys Asp Glu Phe Ile Ser Gln Pro Tyr Gly Asn Trp Ser Asp Cys Ile 
    610                 615                 620                 


Leu Pro Glu Gly Arg Arg Glu Pro His Arg Gly Leu Arg Val Gln Ala 
625                 630                 635                 640 


Asp Ser Lys Glu Cys Gly Glu Gly Leu Arg Phe Arg Ala Val Ala Cys 
                645                 650                 655     


Ser Asp Lys Asn Gly Arg Pro Val Asp Pro Ser Phe Cys Ser Ser Ser 
            660                 665                 670         


Gly Lys Glu Met Asp Gly Glu 
        675                 


<210>  8463
<211>  302
<212>  DNA
<213>  Homosapiens

<400>  8463
cagaattttc aaatcaccga accccaaagt tatgggaatt tgttgccaag ggagaaagac     60

agtggaattt ctgctttcct gatctgcaga aactataaaa ctgacccaat agatatggat    120

atcgcctcat cagcaaagca gcactctcgc atattctttc ctgaagggct tgatgcttcc    180

tgtctggttt ctagctctga ctgatgtaga gggtaatgta aacaccataa agaatccata    240

gggaagttca tataaggcca aaaacggaat ctgaaaataa agtatctaaa tatacatgct    300

aa                                                                   302


<210>  8464
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  8464

Glu Phe Ser Asn His Arg Thr Pro Lys Leu Trp Glu Phe Val Ala Lys 
1               5                   10                  15      


Gly Glu Arg Gln Trp Asn Phe Cys Phe Pro Asp Leu Gln Lys Leu 
            20                  25                  30      


<210>  8465
<211>  289
<212>  DNA
<213>  Homosapiens

<400>  8465
cacaacttcc accacaagga aagtctatta tcatcttcaa gtaaaagaat gcctggtggt     60

aaaggttagc tcatgtattt taagaagagt gatgccaatc caaggggaaa cgtacctagc    120

cctggatatg ataccctttg tgtcgtttgg aaagtgatgc tgttaatacc tcagttgaaa    180

tcttcacatc tcatagtaca ttacctattt ttatatgaaa tcagctgctt cataattaaa    240

tttgatgcat gacatttttg aatgtaaaat tttactagta aataaattg                289


<210>  8466
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  8466

Met Tyr Phe Lys Lys Ser Asp Ala Asn Pro Arg Gly Asn Val Pro Ser 
1               5                   10                  15      


Pro Gly Tyr Asp Thr Leu Cys Val Val Trp Lys Val Met Leu Leu Ile 
            20                  25                  30          


Pro Gln Leu Lys Ser Ser His Leu Ile Val His Tyr Leu Phe Leu Tyr 
        35                  40                  45              


Glu Ile Ser Cys Phe Ile Ile Lys Phe Asp Ala 
    50                  55                  


<210>  8467
<211>  531
<212>  DNA
<213>  Homosapiens

<400>  8467
gtttgtactt tgaagactaa aagaagtaga agacagaatt tcagatcctt taagcattgt     60

gaaaacctag atagcctgtg tctctgtgga actctaaatg aaaatgacag aaaaactaaa    120

agtgagatag gacagagttc agtctattaa aatgaagact tacatgtata aggcaacatt    180

ctgttcttca ggtccctttc caagccaaac taactgaaaa gctgacacct cccttatcat    240

tttaggtcga atgagccgga ctcgatttat cattatgcca acccaaggag aaggacggcc    300

atgccccaca gagcttaccc aggagaaaac ctgcccagtg accccctgct acagctgggt    360

ccttggcaac tggtctgcat gtaaattgga gggtggagac tgtggggaag gagttcagat    420

ccgcagcctt tcctgcatgg tccacagtgg ttcaatatct catgcagctg gacgtgtcga    480

ggatgcactg tgtggagaaa tgccctttca ggacagcatc ctgaagcagc t             531


<210>  8468
<211>  92
<212>  PRT
<213>  Homosapiens

<400>  8468

Met Ser Arg Thr Arg Phe Ile Ile Met Pro Thr Gln Gly Glu Gly Arg 
1               5                   10                  15      


Pro Cys Pro Thr Glu Leu Thr Gln Glu Lys Thr Cys Pro Val Thr Pro 
            20                  25                  30          


Cys Tyr Ser Trp Val Leu Gly Asn Trp Ser Ala Cys Lys Leu Glu Gly 
        35                  40                  45              


Gly Asp Cys Gly Glu Gly Val Gln Ile Arg Ser Leu Ser Cys Met Val 
    50                  55                  60                  


His Ser Gly Ser Ile Ser His Ala Ala Gly Arg Val Glu Asp Ala Leu 
65                  70                  75                  80  


Cys Gly Glu Met Pro Phe Gln Asp Ser Ile Leu Lys 
                85                  90          


<210>  8469
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  8469
ggtctaggag ggagcgcgcc gcacgcgtga gtaaacagcc ggagctggga aagtcgagct     60

ctggcagcgt ctgggtgctg aggggcagag gcggagagaa ccctgtcctg atcttcctag    120

ggtggccgac atgacggcca ggggtcagag ccccctcgcg ccgctgttgg agactttgga    180

agacccttct gcctcccatg gagggcagac tgacgcttac ctgactctga ccagtcgtat    240

gactggagaa gaaggaaaag aagtaattac agaaattgag aaaaaacttc ctcggctgta    300

caaagtttta aagactcaca tttccagtca aaactcggag ctgagtagtg ctgctctaca    360

agccctgggg ttttgcttat ataatcccaa aattacctca gaattatcag aggcaaatgc    420

tctagaattg ctttcaaaat tgaatgatac cattaagaat tcagacaaaa atgtacgtac    480

tagagcactt tgggtgatat ctaagcagac atttccctct gaagtggttg gcaaaatggt    540

atccagtata attgattcat tagaaatact gtttaacaaa ggagagacgc attctgctgt    600

tgttgatttt gaagcattaa atgttatcgt aaggctaatt gaacaagccc caattcaaat    660

gggagaagag gcagtgaggt gggcaaaact ggtcatacct ttagtggttc attcagcaca    720

aaaggtacat ttgcggggag caactgctct ggagatggga atgccattat tgcttcagaa    780

acagcaagaa atagcatcta ttacggagca gcttatgact actaaattaa tctcagaact    840

tcagaagcta tttatgagta aaaatgagac ttacgtgtta aaattatggc ctttgtttgt    900

caaactactt ggaaggacct tgcatcgaag tgggagtttc atcaattctc tcttgcaact    960

agaagaactt ggatttcgta gtggagcacc catgattaaa aagatagctt ttattgcttg   1020

gaagagttta atagataatt ttgctttaaa tccagatata ctatgtagtg caaaaagact   1080

caagttgtta atgcagcctt tgagttccat ccatgtgaga acagaaactc tagcattaac   1140

aaaactagaa gtctggtggt atttactgat gagacttgga cctcatcttc ctgctaattt   1200

tgaacaggtt tgtgtgcctc tgattcaaag tacaataagc attgattcta atgcctcacc   1260

tcagggcaat tcgtgtcatg tagctacatc tccaggttta aatcctatga ctcctgtaca   1320

caaaggtgct tcctccccgt acggagcccc gggaactccc cgaatgaacc tgagttcgaa   1380

tttaggtgga atggccacaa tcccatccat tcaacttttg ggacttgaaa tgttgcttca   1440

tttcttgttg ggtccagaag ccttgagttt tgctaagcaa aataaacttg tgctgagctt   1500

agagccattg gaacatccgt taatcagcag cccttccttt ttttccaaac atgcaaatac   1560

acttatcact gctgttcatg atagctttgt tgcagttgga aaagatgccc ccgatgtggt   1620

tgtcagtgct atctggaagg agctaattag cttggtgaag tcagttactg aatcaggtaa   1680

caaaaaagag aaaccaggtt ctgaagtttt gactctctta ttaaagtctt tggaaagcat   1740

agtaaagtct gaagtatttc ctgtatcaaa aacgctggtc ctcatggaaa ttacaattaa   1800

aggacttcct cagaaagtat taggttcacc agcatatcag gttgctaata tggatattct   1860

taatggaact ccagctttgt tcttaattca attaattttc aacaatttct tggaatgtgg   1920

tgtatcagat gaaaggttct ttctcagttt ggaatcactt gtaggctgtg ttctttctgg   1980

tccaacttca ccactagctt tcagtgactc agttttaaat gttattaatc aaaatgcaaa   2040

gcagttggaa aataaggagc atctctggaa aatgtggagt gttatagtca ccccattaac   2100

tgaattgatt aatcagacca atgaagtaaa tcaaggtgat gccttagaac ataattttag   2160

tgccatctat ggtgcattga ctttaccagt aaaccacatt ttttcagaac agagatttcc   2220

agtggccacc atgaagactt tgcttagaac ttggtcagaa ttatatagag catttgctcg   2280

ttgtgctgct ttggtggcaa cagcagaaga gaacttgtgc tgtgaggaac tttcttccaa   2340

gataatgtcc agtttggaag atgaaggctt ttctaatttg ttgttcgtgg atagaattat   2400

ttatattatt actgtaatgg ttgattgcat tgacttctca ccatataata ttaaatatca   2460

gcccaaagtt aaatcaccac agagaccttc agattggtcc aaaaagaaga atgagcccct   2520

agggaaattg acttctttat ttaaacttat tgtgaaagtg atctattctt tccacacact   2580

gagcttcaag gaagcacatt ctgataccct cttcactatt ggcaactcaa tcaccggcat   2640

tatttccagt gtacttgggc atatttcttt gccttctatg atccgaaaaa tatttgcaac   2700

tttaacaaga cctctggcat tattttatga aaactcaaag cttgatgaag ttcctaaagt   2760

atatagttgt ctgaacaaca agttagaaaa gctactggga gaaattattg cttgtctgca   2820

attcagctac accggaactt atgatagtga acttcttgaa caactctccc cactattatg   2880

cataatattt ctgcacaaga ataaacagat tcgaaaacag agtgctcagt tctggaatgc   2940

cacttttgcc aaagtgatga tgttggttta tcctgaagag ttaaaaccag tactaacaca   3000

agccaaacaa aaatttctgc tcctgttgcc tggtttggaa actgttgaaa tgatggagga   3060

atccagtgga ccatattctg atggaacaga aaattcacaa ctaaatgtga agataagtgg   3120

catggagaga aaatcaaatg gaaaaagaga ttcatttttg gcacaaacaa agaataaaaa   3180

agaaaatatg aaaccagcag ccaaactgaa acttgaatct tcgtctttaa aagtaaaggg   3240

tgaaattctt ttggaagagg aaaagtctac tgactttgtg tttatacctc cagaaggaaa   3300

agatgcaaag gaaagaatat taactgatca tcaaaaagaa gttctcaaaa caaagcggtg   3360

tgatattcct gccatgtata ataatctgga tgtttcccaa gataccttat ttactcagta   3420

tagtcaggaa gagcctatgg aaattcctac tttaaccaga aaaccaaagg aggattctaa   3480

gatgatgatt acggaggagc aaatggacag tgacattgtc attcctcaag atgtcacgga   3540

agactgtggt atggctgaac atcttgaaaa gtcctccctt tcgaataatg agtgtggttc   3600

tcttgacaaa accagtccag aaatgtcaaa cagtaataat gatgaaagaa aaaaagcttt   3660

aatttcatca aggaaaacat caactgaatg tgcatctagt acagaaaatt ctttcgttgt   3720

cagcagtagt tcagtttcta ataccactgt tgctggaact cccccatacc ctacaagtcg   3780

gaggcaaacc tttattactt tggagaagtt tgatggttca gaaaatagac cttttagtcc   3840

atcccccttg aataatattt catcaactgt tacagtgaaa aataaccagg aaaccatgat   3900

taaaacagat tttctaccaa aagcaaagca aagagaaggg actttttcaa aatctgattc   3960

tgaaaaaata gtgaatggaa ctaagagatc aagccggaga gctggtaaag ctgaacaaac   4020

agggaataaa aggtctaagc ccttaatgag atctgagccg gagaaaaata ctgaggaatc   4080

tgttgaaggc attgtagtct tagaaaataa cccacctggt ttgcttaatc aaacagaatg   4140

tgtgtcagat aatcaggttc atctttctga atctacaatg gagcatgaca atacaaagct   4200

taaagcagca acagtggaaa atgctgtatt attggaaact aatactgtag aggagaaaaa   4260

tgtagaaatt aatttggaat ccaaagagaa tacaccccca gtagtaatat cagcagatca   4320

aatggtaaat gaggatagtc aggttcagat aactccaaat cagaaaaccc ttagacggtc   4380

ttcaaggcga cgttcagaag tagtagagtc taccactgaa agccaagata aggaaaatag   4440

tcatcaaaaa aaggaacgac gtaaggaaga agaaaaacct cttcagaaga gtccattgca   4500

tataaaagat gatgtgttac ctaaacaaaa actgattgct gaacaaactc tacaggagaa   4560

tttaattgag aaaggaagta atttacatga gaagactctt ggggaaacta gtgctaatgc   4620

agaaactgaa caaaataaaa aaaaggcaga ccctgagaac attaagtctg agggggatgg   4680

tacccaggac attgtagata agtcctctga gaaactagtc agaggccgaa cacggtatca   4740

aactagaaga gcatctcagg gtttgctttc cagcattgaa aactcagaat ctgatagttc   4800

ggaggcaaaa gaagaaggtt ctaggaagaa gagatctgga aaatggaaaa acaaaagcaa   4860

tgaaagtgtt gacattcaag atcaagaaga gaaagtggtg aaacaggaat gtataaaagc   4920

tgaaaatcag tcacatgatt ataaagcaac ttctgaagaa gatgtaagca taaaatctcc   4980

gatttgcgaa aaacaagatg aaagtaatac tgtaatatgt caggattcta cagtaacttc   5040

agatttgttg caagttcctg atgatttacc aaatgtgtgt gaggaaaaaa atgaaactag   5100

caaatatgca gaatattcct ttacaagtct acctgtgcca gaatcaaatc taaggactag   5160

aaatgccatt aagagattac ataagcgaga ctcttttgat aattgtagtt tgggagaatc   5220

ctcaaaaata gggatatcag atatttcttc gctttcagaa aaaacttttc aaacacttga   5280

atgccaacac aagagaagta ggagggtgag gagatctaaa ggttgtgatt gctgtgggga   5340

aaaatcacaa cctcaggaaa agtcactcat tgggttaaag aatacagaaa ataatgacgt   5400

agagattagt gaaacaaaaa aggcagatgt gcaagcacct gtaagcccat cagaaacttc   5460

tcaagctaat ccatattctg aaggacaatt tttagatgaa catcatagtg tgaattttca   5520

tttgggtctc aaagaggata atgatactat taatgattca ttaattgttt ctgaaaccaa   5580

atcaaaagaa aacactatgc aagaatctct tccttctgga atagtaaact ttagagagga   5640

aatttgtgat atggattcta gtgaagcaat gtctcttgaa agccaggagt cacctaatga   5700

aaattttaaa actgttggcc cgtgtttagg agactcgaaa aatgtttcac aggaatcttt   5760

ggagacaaaa gaagaaaaac cagaagaaac cccaaaaatg gaactgagtc tagagaatgt   5820

tactgttgaa ggaaatgcat gtaaagtaac agaatccaat ctagagaaag caaaaactat   5880

ggaattgaat gtaggaaatg aagctagctt tcatggacaa gagagaacca aaactggtat   5940

ttctgaagaa gcagcaatag aagaaaataa aagaaatgat gactctgaag cagacacagc   6000

taaactgaat gccaaagaag tagcaactga ggaatttaat tcagatatta gtctttctga   6060

taatactaca cctgtaaaat tgaatgctca aactgagatt tctgaacaaa cagcagctgg   6120

ggaactagat ggaggaaatg atgtatctga tctacactca tctgaagaaa cgaataccaa   6180

aatgaaaaat aatgaagaaa tgatgatcgg cgaggcaatg gctgaaactg gccatgatgg   6240

tgaaacagag aatgagggca taactaccaa aacctcaaag cctgatgaag ctgaaacaaa   6300

catgttgact gcagaaatgg acaactttgt ttgtgacaca gttgaaatga gcactgaaga   6360

aggaatcatt gacgctaata aaactgaaac aaatactgag tatagtaaat ctgaagaaaa   6420

attagataac aatcaaatgg taatggaaag tgatatttta caggaagatc accatacttc   6480

acagaaagtg gaggaaccat cacagtgtct ggcatctgga acagctatct ctgagctaat   6540

aatagaagac aataatgcat ctcctcaaaa actaagggaa cttgatcctt cacttgtgtc   6600

agcaaatgac agtcctagtg gcatgcagac acgctgtgtc tggtctcctt tggcttctcc   6660

gtctacgagc attttaaaga gaggactaaa aagatcccaa gaagatgaaa tctcatcacc   6720

tgttaataag gttcgccgtg tctcctttgc agatccaata taccaagcag gattggcaga   6780

tgacattgat agacggtgct ctattgttag gtcccattct tccaatagtt ctcccatagg   6840

aaaaagtgtt aaaacttctc ctactacaca atctaagcat aataccactt cagccaaagg   6900

atttctgtcc ccaggatcac gtagccctaa atttaagagc tcaaagaagt gtttaatttc   6960

agaaatggcc aaagaatcca taccatgccc aacagaaagt gtttacccac cattggtgaa   7020

ctgtgtggca ccagttgaca tcattttacc tcagattaca tcaaacatgt gggcaagagg   7080

cctgggacaa ctcattagag ctaagaatat aaaaactatt ggtgatttga gtactcttac   7140

agcatctgaa ataaaaactc ttcctatccg ttctccaaaa gtgtccaatg taaaaaaggc   7200

tctcagaata tatcatgagc agcaggtgaa gactcgtgga ctagaagaga ttccagtttt   7260

tgatatttct gaaaaaacag taaatggaat agaaaataaa tctttgtcac ctgatgaaga   7320

aagacttgtc tcagatataa ttgatcctgt tgctttagaa attccattat ccaaaaacct   7380

tctggcacag attagtgctc ttgctcttca gctggattca gaagatcttc ataattattc   7440

aggaagccaa ctatttgaaa tgcacgagaa actaagttgt atggcaaact ctgtaataaa   7500

aaatctacag tcacgttgga gatcaccatc ccatgaaaat tctatttagt attttcagag   7560

aaaattgaag gtttttttaa acatcactgg atttcttgat tgaggaaaca agttctgaaa   7620

taatagcaca atttcaaaga agagactctt tgcaaagttg ataacatttc aaaccctgaa   7680

ggacagtgac ttattatgta agttcaattt tgtaagttca ttatgtaaga tccttttttt   7740

tttcataata tgtattcttg gctgctatgc gtggtttttc aggaaattta attatcttac   7800

tgagatgtga aagcaaaact agtaacagaa cttacatttt atttcatgct ttcttaaacc   7860

cgtgcatatt ctggtgaaac atgtaaaata ctttaagtaa aattgaacat ttttatttga   7920

atttttgctg aactgataaa ggtgtttata tttttgtttg ttggtttgtt taattcatgt   7980

ttgttgggac tgaggtttag gaagtttgtt actggttaaa aacctcaaat gaaatgcgaa   8040

agaatttgaa tttttcctgc atatgtcaac tttggacagc tttcaagaaa aatgagaaaa   8100

gtttcaactt ctggcggtta aaatattaat gcagaattta ctaagatttt attcatttgc   8160

attagcaaat attcatgcag cagcagttga ct                                 8192


<210>  8470
<211>  2472
<212>  PRT
<213>  Homosapiens

<400>  8470

Met Thr Ala Arg Gly Gln Ser Pro Leu Ala Pro Leu Leu Glu Thr Leu 
1               5                   10                  15      


Glu Asp Pro Ser Ala Ser His Gly Gly Gln Thr Asp Ala Tyr Leu Thr 
            20                  25                  30          


Leu Thr Ser Arg Met Thr Gly Glu Glu Gly Lys Glu Val Ile Thr Glu 
        35                  40                  45              


Ile Glu Lys Lys Leu Pro Arg Leu Tyr Lys Val Leu Lys Thr His Ile 
    50                  55                  60                  


Ser Ser Gln Asn Ser Glu Leu Ser Ser Ala Ala Leu Gln Ala Leu Gly 
65                  70                  75                  80  


Phe Cys Leu Tyr Asn Pro Lys Ile Thr Ser Glu Leu Ser Glu Ala Asn 
                85                  90                  95      


Ala Leu Glu Leu Leu Ser Lys Leu Asn Asp Thr Ile Lys Asn Ser Asp 
            100                 105                 110         


Lys Asn Val Arg Thr Arg Ala Leu Trp Val Ile Ser Lys Gln Thr Phe 
        115                 120                 125             


Pro Ser Glu Val Val Gly Lys Met Val Ser Ser Ile Ile Asp Ser Leu 
    130                 135                 140                 


Glu Ile Leu Phe Asn Lys Gly Glu Thr His Ser Ala Val Val Asp Phe 
145                 150                 155                 160 


Glu Ala Leu Asn Val Ile Val Arg Leu Ile Glu Gln Ala Pro Ile Gln 
                165                 170                 175     


Met Gly Glu Glu Ala Val Arg Trp Ala Lys Leu Val Ile Pro Leu Val 
            180                 185                 190         


Val His Ser Ala Gln Lys Val His Leu Arg Gly Ala Thr Ala Leu Glu 
        195                 200                 205             


Met Gly Met Pro Leu Leu Leu Gln Lys Gln Gln Glu Ile Ala Ser Ile 
    210                 215                 220                 


Thr Glu Gln Leu Met Thr Thr Lys Leu Ile Ser Glu Leu Gln Lys Leu 
225                 230                 235                 240 


Phe Met Ser Lys Asn Glu Thr Tyr Val Leu Lys Leu Trp Pro Leu Phe 
                245                 250                 255     


Val Lys Leu Leu Gly Arg Thr Leu His Arg Ser Gly Ser Phe Ile Asn 
            260                 265                 270         


Ser Leu Leu Gln Leu Glu Glu Leu Gly Phe Arg Ser Gly Ala Pro Met 
        275                 280                 285             


Ile Lys Lys Ile Ala Phe Ile Ala Trp Lys Ser Leu Ile Asp Asn Phe 
    290                 295                 300                 


Ala Leu Asn Pro Asp Ile Leu Cys Ser Ala Lys Arg Leu Lys Leu Leu 
305                 310                 315                 320 


Met Gln Pro Leu Ser Ser Ile His Val Arg Thr Glu Thr Leu Ala Leu 
                325                 330                 335     


Thr Lys Leu Glu Val Trp Trp Tyr Leu Leu Met Arg Leu Gly Pro His 
            340                 345                 350         


Leu Pro Ala Asn Phe Glu Gln Val Cys Val Pro Leu Ile Gln Ser Thr 
        355                 360                 365             


Ile Ser Ile Asp Ser Asn Ala Ser Pro Gln Gly Asn Ser Cys His Val 
    370                 375                 380                 


Ala Thr Ser Pro Gly Leu Asn Pro Met Thr Pro Val His Lys Gly Ala 
385                 390                 395                 400 


Ser Ser Pro Tyr Gly Ala Pro Gly Thr Pro Arg Met Asn Leu Ser Ser 
                405                 410                 415     


Asn Leu Gly Gly Met Ala Thr Ile Pro Ser Ile Gln Leu Leu Gly Leu 
            420                 425                 430         


Glu Met Leu Leu His Phe Leu Leu Gly Pro Glu Ala Leu Ser Phe Ala 
        435                 440                 445             


Lys Gln Asn Lys Leu Val Leu Ser Leu Glu Pro Leu Glu His Pro Leu 
    450                 455                 460                 


Ile Ser Ser Pro Ser Phe Phe Ser Lys His Ala Asn Thr Leu Ile Thr 
465                 470                 475                 480 


Ala Val His Asp Ser Phe Val Ala Val Gly Lys Asp Ala Pro Asp Val 
                485                 490                 495     


Val Val Ser Ala Ile Trp Lys Glu Leu Ile Ser Leu Val Lys Ser Val 
            500                 505                 510         


Thr Glu Ser Gly Asn Lys Lys Glu Lys Pro Gly Ser Glu Val Leu Thr 
        515                 520                 525             


Leu Leu Leu Lys Ser Leu Glu Ser Ile Val Lys Ser Glu Val Phe Pro 
    530                 535                 540                 


Val Ser Lys Thr Leu Val Leu Met Glu Ile Thr Ile Lys Gly Leu Pro 
545                 550                 555                 560 


Gln Lys Val Leu Gly Ser Pro Ala Tyr Gln Val Ala Asn Met Asp Ile 
                565                 570                 575     


Leu Asn Gly Thr Pro Ala Leu Phe Leu Ile Gln Leu Ile Phe Asn Asn 
            580                 585                 590         


Phe Leu Glu Cys Gly Val Ser Asp Glu Arg Phe Phe Leu Ser Leu Glu 
        595                 600                 605             


Ser Leu Val Gly Cys Val Leu Ser Gly Pro Thr Ser Pro Leu Ala Phe 
    610                 615                 620                 


Ser Asp Ser Val Leu Asn Val Ile Asn Gln Asn Ala Lys Gln Leu Glu 
625                 630                 635                 640 


Asn Lys Glu His Leu Trp Lys Met Trp Ser Val Ile Val Thr Pro Leu 
                645                 650                 655     


Thr Glu Leu Ile Asn Gln Thr Asn Glu Val Asn Gln Gly Asp Ala Leu 
            660                 665                 670         


Glu His Asn Phe Ser Ala Ile Tyr Gly Ala Leu Thr Leu Pro Val Asn 
        675                 680                 685             


His Ile Phe Ser Glu Gln Arg Phe Pro Val Ala Thr Met Lys Thr Leu 
    690                 695                 700                 


Leu Arg Thr Trp Ser Glu Leu Tyr Arg Ala Phe Ala Arg Cys Ala Ala 
705                 710                 715                 720 


Leu Val Ala Thr Ala Glu Glu Asn Leu Cys Cys Glu Glu Leu Ser Ser 
                725                 730                 735     


Lys Ile Met Ser Ser Leu Glu Asp Glu Gly Phe Ser Asn Leu Leu Phe 
            740                 745                 750         


Val Asp Arg Ile Ile Tyr Ile Ile Thr Val Met Val Asp Cys Ile Asp 
        755                 760                 765             


Phe Ser Pro Tyr Asn Ile Lys Tyr Gln Pro Lys Val Lys Ser Pro Gln 
    770                 775                 780                 


Arg Pro Ser Asp Trp Ser Lys Lys Lys Asn Glu Pro Leu Gly Lys Leu 
785                 790                 795                 800 


Thr Ser Leu Phe Lys Leu Ile Val Lys Val Ile Tyr Ser Phe His Thr 
                805                 810                 815     


Leu Ser Phe Lys Glu Ala His Ser Asp Thr Leu Phe Thr Ile Gly Asn 
            820                 825                 830         


Ser Ile Thr Gly Ile Ile Ser Ser Val Leu Gly His Ile Ser Leu Pro 
        835                 840                 845             


Ser Met Ile Arg Lys Ile Phe Ala Thr Leu Thr Arg Pro Leu Ala Leu 
    850                 855                 860                 


Phe Tyr Glu Asn Ser Lys Leu Asp Glu Val Pro Lys Val Tyr Ser Cys 
865                 870                 875                 880 


Leu Asn Asn Lys Leu Glu Lys Leu Leu Gly Glu Ile Ile Ala Cys Leu 
                885                 890                 895     


Gln Phe Ser Tyr Thr Gly Thr Tyr Asp Ser Glu Leu Leu Glu Gln Leu 
            900                 905                 910         


Ser Pro Leu Leu Cys Ile Ile Phe Leu His Lys Asn Lys Gln Ile Arg 
        915                 920                 925             


Lys Gln Ser Ala Gln Phe Trp Asn Ala Thr Phe Ala Lys Val Met Met 
    930                 935                 940                 


Leu Val Tyr Pro Glu Glu Leu Lys Pro Val Leu Thr Gln Ala Lys Gln 
945                 950                 955                 960 


Lys Phe Leu Leu Leu Leu Pro Gly Leu Glu Thr Val Glu Met Met Glu 
                965                 970                 975     


Glu Ser Ser Gly Pro Tyr Ser Asp Gly Thr Glu Asn Ser Gln Leu Asn 
            980                 985                 990         


Val Lys Ile Ser Gly Met Glu Arg  Lys Ser Asn Gly Lys  Arg Asp Ser 
        995                 1000                 1005             


Phe Leu  Ala Gln Thr Lys Asn  Lys Lys Glu Asn Met  Lys Pro Ala 
    1010                 1015                 1020             


Ala Lys  Leu Lys Leu Glu Ser  Ser Ser Leu Lys Val  Lys Gly Glu 
    1025                 1030                 1035             


Ile Leu  Leu Glu Glu Glu Lys  Ser Thr Asp Phe Val  Phe Ile Pro 
    1040                 1045                 1050             


Pro Glu  Gly Lys Asp Ala Lys  Glu Arg Ile Leu Thr  Asp His Gln 
    1055                 1060                 1065             


Lys Glu  Val Leu Lys Thr Lys  Arg Cys Asp Ile Pro  Ala Met Tyr 
    1070                 1075                 1080             


Asn Asn  Leu Asp Val Ser Gln  Asp Thr Leu Phe Thr  Gln Tyr Ser 
    1085                 1090                 1095             


Gln Glu  Glu Pro Met Glu Ile  Pro Thr Leu Thr Arg  Lys Pro Lys 
    1100                 1105                 1110             


Glu Asp  Ser Lys Met Met Ile  Thr Glu Glu Gln Met  Asp Ser Asp 
    1115                 1120                 1125             


Ile Val  Ile Pro Gln Asp Val  Thr Glu Asp Cys Gly  Met Ala Glu 
    1130                 1135                 1140             


His Leu  Glu Lys Ser Ser Leu  Ser Asn Asn Glu Cys  Gly Ser Leu 
    1145                 1150                 1155             


Asp Lys  Thr Ser Pro Glu Met  Ser Asn Ser Asn Asn  Asp Glu Arg 
    1160                 1165                 1170             


Lys Lys  Ala Leu Ile Ser Ser  Arg Lys Thr Ser Thr  Glu Cys Ala 
    1175                 1180                 1185             


Ser Ser  Thr Glu Asn Ser Phe  Val Val Ser Ser Ser  Ser Val Ser 
    1190                 1195                 1200             


Asn Thr  Thr Val Ala Gly Thr  Pro Pro Tyr Pro Thr  Ser Arg Arg 
    1205                 1210                 1215             


Gln Thr  Phe Ile Thr Leu Glu  Lys Phe Asp Gly Ser  Glu Asn Arg 
    1220                 1225                 1230             


Pro Phe  Ser Pro Ser Pro Leu  Asn Asn Ile Ser Ser  Thr Val Thr 
    1235                 1240                 1245             


Val Lys  Asn Asn Gln Glu Thr  Met Ile Lys Thr Asp  Phe Leu Pro 
    1250                 1255                 1260             


Lys Ala  Lys Gln Arg Glu Gly  Thr Phe Ser Lys Ser  Asp Ser Glu 
    1265                 1270                 1275             


Lys Ile  Val Asn Gly Thr Lys  Arg Ser Ser Arg Arg  Ala Gly Lys 
    1280                 1285                 1290             


Ala Glu  Gln Thr Gly Asn Lys  Arg Ser Lys Pro Leu  Met Arg Ser 
    1295                 1300                 1305             


Glu Pro  Glu Lys Asn Thr Glu  Glu Ser Val Glu Gly  Ile Val Val 
    1310                 1315                 1320             


Leu Glu  Asn Asn Pro Pro Gly  Leu Leu Asn Gln Thr  Glu Cys Val 
    1325                 1330                 1335             


Ser Asp  Asn Gln Val His Leu  Ser Glu Ser Thr Met  Glu His Asp 
    1340                 1345                 1350             


Asn Thr  Lys Leu Lys Ala Ala  Thr Val Glu Asn Ala  Val Leu Leu 
    1355                 1360                 1365             


Glu Thr  Asn Thr Val Glu Glu  Lys Asn Val Glu Ile  Asn Leu Glu 
    1370                 1375                 1380             


Ser Lys  Glu Asn Thr Pro Pro  Val Val Ile Ser Ala  Asp Gln Met 
    1385                 1390                 1395             


Val Asn  Glu Asp Ser Gln Val  Gln Ile Thr Pro Asn  Gln Lys Thr 
    1400                 1405                 1410             


Leu Arg  Arg Ser Ser Arg Arg  Arg Ser Glu Val Val  Glu Ser Thr 
    1415                 1420                 1425             


Thr Glu  Ser Gln Asp Lys Glu  Asn Ser His Gln Lys  Lys Glu Arg 
    1430                 1435                 1440             


Arg Lys  Glu Glu Glu Lys Pro  Leu Gln Lys Ser Pro  Leu His Ile 
    1445                 1450                 1455             


Lys Asp  Asp Val Leu Pro Lys  Gln Lys Leu Ile Ala  Glu Gln Thr 
    1460                 1465                 1470             


Leu Gln  Glu Asn Leu Ile Glu  Lys Gly Ser Asn Leu  His Glu Lys 
    1475                 1480                 1485             


Thr Leu  Gly Glu Thr Ser Ala  Asn Ala Glu Thr Glu  Gln Asn Lys 
    1490                 1495                 1500             


Lys Lys  Ala Asp Pro Glu Asn  Ile Lys Ser Glu Gly  Asp Gly Thr 
    1505                 1510                 1515             


Gln Asp  Ile Val Asp Lys Ser  Ser Glu Lys Leu Val  Arg Gly Arg 
    1520                 1525                 1530             


Thr Arg  Tyr Gln Thr Arg Arg  Ala Ser Gln Gly Leu  Leu Ser Ser 
    1535                 1540                 1545             


Ile Glu  Asn Ser Glu Ser Asp  Ser Ser Glu Ala Lys  Glu Glu Gly 
    1550                 1555                 1560             


Ser Arg  Lys Lys Arg Ser Gly  Lys Trp Lys Asn Lys  Ser Asn Glu 
    1565                 1570                 1575             


Ser Val  Asp Ile Gln Asp Gln  Glu Glu Lys Val Val  Lys Gln Glu 
    1580                 1585                 1590             


Cys Ile  Lys Ala Glu Asn Gln  Ser His Asp Tyr Lys  Ala Thr Ser 
    1595                 1600                 1605             


Glu Glu  Asp Val Ser Ile Lys  Ser Pro Ile Cys Glu  Lys Gln Asp 
    1610                 1615                 1620             


Glu Ser  Asn Thr Val Ile Cys  Gln Asp Ser Thr Val  Thr Ser Asp 
    1625                 1630                 1635             


Leu Leu  Gln Val Pro Asp Asp  Leu Pro Asn Val Cys  Glu Glu Lys 
    1640                 1645                 1650             


Asn Glu  Thr Ser Lys Tyr Ala  Glu Tyr Ser Phe Thr  Ser Leu Pro 
    1655                 1660                 1665             


Val Pro  Glu Ser Asn Leu Arg  Thr Arg Asn Ala Ile  Lys Arg Leu 
    1670                 1675                 1680             


His Lys  Arg Asp Ser Phe Asp  Asn Cys Ser Leu Gly  Glu Ser Ser 
    1685                 1690                 1695             


Lys Ile  Gly Ile Ser Asp Ile  Ser Ser Leu Ser Glu  Lys Thr Phe 
    1700                 1705                 1710             


Gln Thr  Leu Glu Cys Gln His  Lys Arg Ser Arg Arg  Val Arg Arg 
    1715                 1720                 1725             


Ser Lys  Gly Cys Asp Cys Cys  Gly Glu Lys Ser Gln  Pro Gln Glu 
    1730                 1735                 1740             


Lys Ser  Leu Ile Gly Leu Lys  Asn Thr Glu Asn Asn  Asp Val Glu 
    1745                 1750                 1755             


Ile Ser  Glu Thr Lys Lys Ala  Asp Val Gln Ala Pro  Val Ser Pro 
    1760                 1765                 1770             


Ser Glu  Thr Ser Gln Ala Asn  Pro Tyr Ser Glu Gly  Gln Phe Leu 
    1775                 1780                 1785             


Asp Glu  His His Ser Val Asn  Phe His Leu Gly Leu  Lys Glu Asp 
    1790                 1795                 1800             


Asn Asp  Thr Ile Asn Asp Ser  Leu Ile Val Ser Glu  Thr Lys Ser 
    1805                 1810                 1815             


Lys Glu  Asn Thr Met Gln Glu  Ser Leu Pro Ser Gly  Ile Val Asn 
    1820                 1825                 1830             


Phe Arg  Glu Glu Ile Cys Asp  Met Asp Ser Ser Glu  Ala Met Ser 
    1835                 1840                 1845             


Leu Glu  Ser Gln Glu Ser Pro  Asn Glu Asn Phe Lys  Thr Val Gly 
    1850                 1855                 1860             


Pro Cys  Leu Gly Asp Ser Lys  Asn Val Ser Gln Glu  Ser Leu Glu 
    1865                 1870                 1875             


Thr Lys  Glu Glu Lys Pro Glu  Glu Thr Pro Lys Met  Glu Leu Ser 
    1880                 1885                 1890             


Leu Glu  Asn Val Thr Val Glu  Gly Asn Ala Cys Lys  Val Thr Glu 
    1895                 1900                 1905             


Ser Asn  Leu Glu Lys Ala Lys  Thr Met Glu Leu Asn  Val Gly Asn 
    1910                 1915                 1920             


Glu Ala  Ser Phe His Gly Gln  Glu Arg Thr Lys Thr  Gly Ile Ser 
    1925                 1930                 1935             


Glu Glu  Ala Ala Ile Glu Glu  Asn Lys Arg Asn Asp  Asp Ser Glu 
    1940                 1945                 1950             


Ala Asp  Thr Ala Lys Leu Asn  Ala Lys Glu Val Ala  Thr Glu Glu 
    1955                 1960                 1965             


Phe Asn  Ser Asp Ile Ser Leu  Ser Asp Asn Thr Thr  Pro Val Lys 
    1970                 1975                 1980             


Leu Asn  Ala Gln Thr Glu Ile  Ser Glu Gln Thr Ala  Ala Gly Glu 
    1985                 1990                 1995             


Leu Asp  Gly Gly Asn Asp Val  Ser Asp Leu His Ser  Ser Glu Glu 
    2000                 2005                 2010             


Thr Asn  Thr Lys Met Lys Asn  Asn Glu Glu Met Met  Ile Gly Glu 
    2015                 2020                 2025             


Ala Met  Ala Glu Thr Gly His  Asp Gly Glu Thr Glu  Asn Glu Gly 
    2030                 2035                 2040             


Ile Thr  Thr Lys Thr Ser Lys  Pro Asp Glu Ala Glu  Thr Asn Met 
    2045                 2050                 2055             


Leu Thr  Ala Glu Met Asp Asn  Phe Val Cys Asp Thr  Val Glu Met 
    2060                 2065                 2070             


Ser Thr  Glu Glu Gly Ile Ile  Asp Ala Asn Lys Thr  Glu Thr Asn 
    2075                 2080                 2085             


Thr Glu  Tyr Ser Lys Ser Glu  Glu Lys Leu Asp Asn  Asn Gln Met 
    2090                 2095                 2100             


Val Met  Glu Ser Asp Ile Leu  Gln Glu Asp His His  Thr Ser Gln 
    2105                 2110                 2115             


Lys Val  Glu Glu Pro Ser Gln  Cys Leu Ala Ser Gly  Thr Ala Ile 
    2120                 2125                 2130             


Ser Glu  Leu Ile Ile Glu Asp  Asn Asn Ala Ser Pro  Gln Lys Leu 
    2135                 2140                 2145             


Arg Glu  Leu Asp Pro Ser Leu  Val Ser Ala Asn Asp  Ser Pro Ser 
    2150                 2155                 2160             


Gly Met  Gln Thr Arg Cys Val  Trp Ser Pro Leu Ala  Ser Pro Ser 
    2165                 2170                 2175             


Thr Ser  Ile Leu Lys Arg Gly  Leu Lys Arg Ser Gln  Glu Asp Glu 
    2180                 2185                 2190             


Ile Ser  Ser Pro Val Asn Lys  Val Arg Arg Val Ser  Phe Ala Asp 
    2195                 2200                 2205             


Pro Ile  Tyr Gln Ala Gly Leu  Ala Asp Asp Ile Asp  Arg Arg Cys 
    2210                 2215                 2220             


Ser Ile  Val Arg Ser His Ser  Ser Asn Ser Ser Pro  Ile Gly Lys 
    2225                 2230                 2235             


Ser Val  Lys Thr Ser Pro Thr  Thr Gln Ser Lys His  Asn Thr Thr 
    2240                 2245                 2250             


Ser Ala  Lys Gly Phe Leu Ser  Pro Gly Ser Arg Ser  Pro Lys Phe 
    2255                 2260                 2265             


Lys Ser  Ser Lys Lys Cys Leu  Ile Ser Glu Met Ala  Lys Glu Ser 
    2270                 2275                 2280             


Ile Pro  Cys Pro Thr Glu Ser  Val Tyr Pro Pro Leu  Val Asn Cys 
    2285                 2290                 2295             


Val Ala  Pro Val Asp Ile Ile  Leu Pro Gln Ile Thr  Ser Asn Met 
    2300                 2305                 2310             


Trp Ala  Arg Gly Leu Gly Gln  Leu Ile Arg Ala Lys  Asn Ile Lys 
    2315                 2320                 2325             


Thr Ile  Gly Asp Leu Ser Thr  Leu Thr Ala Ser Glu  Ile Lys Thr 
    2330                 2335                 2340             


Leu Pro  Ile Arg Ser Pro Lys  Val Ser Asn Val Lys  Lys Ala Leu 
    2345                 2350                 2355             


Arg Ile  Tyr His Glu Gln Gln  Val Lys Thr Arg Gly  Leu Glu Glu 
    2360                 2365                 2370             


Ile Pro  Val Phe Asp Ile Ser  Glu Lys Thr Val Asn  Gly Ile Glu 
    2375                 2380                 2385             


Asn Lys  Ser Leu Ser Pro Asp  Glu Glu Arg Leu Val  Ser Asp Ile 
    2390                 2395                 2400             


Ile Asp  Pro Val Ala Leu Glu  Ile Pro Leu Ser Lys  Asn Leu Leu 
    2405                 2410                 2415             


Ala Gln  Ile Ser Ala Leu Ala  Leu Gln Leu Asp Ser  Glu Asp Leu 
    2420                 2425                 2430             


His Asn  Tyr Ser Gly Ser Gln  Leu Phe Glu Met His  Glu Lys Leu 
    2435                 2440                 2445             


Ser Cys  Met Ala Asn Ser Val  Ile Lys Asn Leu Gln  Ser Arg Trp 
    2450                 2455                 2460             


Arg Ser  Pro Ser His Glu Asn  Ser Ile 
    2465                 2470         


<210>  8471
<211>  4434
<212>  DNA
<213>  Homosapiens

<400>  8471
agataaggaa aatagtcatc aaaaaaagga acgacgtaag gaagaagaaa aacctcttca     60

gaagagtcca ttgcatataa aagatgatgt gttacctaaa caaaaactga ttgctgaaca    120

aactctacag gagaatttaa ttgagaaagg aagtaattta catgagaaga ctcttgggga    180

aactagtgct aatgcagaaa ctgaacaaaa taaaaaaaag gcagaccctg agaacattaa    240

gtctgagggg gatggtaccc aggacattgt agataagtcc tctgagaaac tagtcagagg    300

ccgaacacgg tatcaaacta gaagagcatc tcagggtttg ctttccagca ttgaaaactc    360

agaatctgat agttcggagg caaaagaaga aggttctagg aagaagagat ctggaaaatg    420

gaaaaacaaa agcaatgaaa gtgttgacat tcaagatcaa gaagagaaag tggtgaaaca    480

ggaatgtata aaagctgaaa atcagtcaca tgattataaa gcaacttctg aagaagatgt    540

aagcataaaa tctccgattt gcgaaaaaca agatgaaagt aatactgtaa tatgtcagga    600

ttctacagta acttcagatt tgttgcaagt tcctgatgat ttaccaaatg tgtgtgagga    660

aaaaaatgaa actagcaaat atgcagaata ttcctttaca agtctacctg tgccagaatc    720

aaatctaagg actagaaatg ccattaagag attacataag cgagactctt ttgataattg    780

tagtttggga gaatcctcaa aaatagggat atcagatatt tcttcgcttt cagaaaaaac    840

ttttcaaaca cttgaatgcc aacacaagag aagtaggagg gtgaggagat ctaaaggttg    900

tgattgctgt ggggaaaaat cacaacctca ggaaaagtca ctcattgggt taaagaatac    960

agaaaataat gacgtagaga ttagtgaaac aaaaaaggca gatgtgcaag cacctgtaag   1020

cccatcagaa acttctcaag ctaatccata ttctgaagga caatttttag atgaacatca   1080

tagtgtgaat tttcatttgg gtctcaaaga ggataatgat actattaatg attcattaat   1140

tgtttctgaa accaaatcaa aagaaaacac tatgcaagaa tctcttcctt ctggaatagt   1200

aaactttaga gaggaaattt gtgatatgga ttctagtgaa gcaatgtctc ttgaaagcca   1260

ggagtcacct aatgaaaatt ttaaaactgt tggcccgtgt ttaggagact cgaaaaatgt   1320

ttcacaggaa tctttggaga caaaagaaga aaaaccagaa gaaaccccaa aaatggaact   1380

gagtctagag aatgttactg ttgaaggaaa tgcatgtaaa gtaacagaat ccaatctaga   1440

gaaagcaaaa actatggaat tgaatgtagg aaatgaagct agctttcatg gacaagagag   1500

aaccaaaact ggtatttctg aagaagcagc aatagaagaa aataaaagaa atgatgactc   1560

tgaagcagac acagctaaac tgaatgccaa agaagtagca actgaggaat ttaattcaga   1620

tattagtctt tctgataata ctacacctgt aaaattgaat gctcaaactg agatttctga   1680

acaaacagca gctggggaac tagatggagg aaatgatgta tctgatctac actcatctga   1740

agaaacgaat accaaaatga aaaataatga agaaatgatg atcggcgagg caatggctga   1800

aactggccat gatggtgaaa cagagaatga gggcataact accaaaacct caaagcctga   1860

tgaagctgaa acaaacatgt tgactgcaga aatggacaac tttgtttgtg acacagttga   1920

aatgagcact gaagaaggaa tcattgacgc taataaaact gaaacaaata ctgagtatag   1980

taaatctgaa gaaaaattag ataacaatca aatggtaatg gaaagtgata ttttacagga   2040

agatcaccat acttcacaga aagtggagga accatcacag tgtctggcat ctggaacagc   2100

tatctctgag ctaataatag aagacaataa tgcatctcct caaaaactaa gggaacttga   2160

tccttcactt gtgtcagcaa atgacagtcc tagtggcatg cagacacgct gtgtctggtc   2220

tcctttggct tctccgtcta cgagcatttt aaagagagga ctaaaaagat cccaagaaga   2280

tgaaatctca tcacctgtta ataaggttcg ccgtgtctcc tttgcagatc caatatacca   2340

agcaggattg gcagatgaca ttgatagacg gtgctctatt gttaggtccc attcttccaa   2400

tagttctccc ataggaaaaa gtgttaaaac ttctcctact acacaatcta agcataatac   2460

cacttcagcc aaaggatttc tgtccccagg atcacgtagc cctaaattta agagctcaaa   2520

gaagtgttta atttcagaaa tggccaaaga atccatacca tgcccaacag aaagtgttta   2580

cccaccattg gtgaactgtg tggcaccagt tgacatcatt ttacctcaga ttacatcaaa   2640

catgtgggca agaggcctgg gacaactcat tagagctaag aatataaaaa ctattggtga   2700

tttgagtact cttacagcat ctgaaataaa aactcttcct atccgttctc caaaagtgtc   2760

caatgtaaaa aaggctctca gaatatatca tgagcagcag gtgaagactc gtggactaga   2820

agagattcca gtttttgata tttctgaaaa aacagtaaat ggaatagaaa ataaatcttt   2880

gtcacctgat gaagaaagac ttgtctcaga tataattgat cctgttgctt tagaaattcc   2940

attatccaaa aaccttctgg cacagattag tgctcttgct cttcagctgg attcagaaga   3000

tcttcataat tattcaggaa gccaactatt tgaaatgcac gagaaactaa gttgtatggc   3060

aaactctgta ataaaaaatc tacagtcacg ttggagatca ccatcccatg aaaattctat   3120

ttagtatttt cagagaaaat tgaaggtttt tttaaacatc actggatttc ttgattgagg   3180

aaacaagttc tgaaataata gcacaatttc aaagaagaga ctctttgcaa agttgataac   3240

atttcaaacc ctgaaggaca gtgacttatt atccttcctt tctccaaaga acagttaaaa   3300

ccaaatgtgt tatggtaagc tgtaaatacc gttggaataa aagataaccg ttcatcttac   3360

ctaaaaaatt gaagacaata ttttccattg ttgatgtcac aatttcttga agatggctct   3420

ttgcagccta cgtggtagtg gagatatata caaaggactt ccctagtatc gttggaccaa   3480

caagcacaag cagatggcag gaagattaga acattggata ttgattgcca gtttttaagt   3540

gtcattcttg gaaacgtggg agatttagga aatgacattg aagaggaaga attctgttga   3600

aatagtgatt ctcaacgtgg ggtccttgga cagcaagtga tggggattgg aatccctttt   3660

ccaacgtttt ctttatacaa cacctgtatg acacaagaaa gcatccagaa aaaacaagag   3720

cagtcaaaac agccctttca tctaccttgt ggggaacctg gtataaaact acagacgtca   3780

gacagaaaag acagattcaa caagtcaacc tctctgttca ggcacagatc tggttttaat   3840

gatgaactct acaatgctaa ttctggaaat gaaaaagtac aatggaaagc attaagttat   3900

ataacgctga ggaatcttgt taattctact tatagtattt caaatctagt caagtcactg   3960

aaaatgttca agtataatcg gaaatgtgtc tttccgatag ccgttcctgg tgagacatcc   4020

tctttatata aaacctgggc attcagaatc aggacagtgt taacacagaa gaaaagaaaa   4080

cccagcagtt cctggagaaa gactaggaca catggctttt gtgaaaacaa gacactagac   4140

gatgttccca ggggttttcg ccatgaacct tgccatgggt gaggaaaaga tactatattt   4200

tctccccaat accaccaacg aagtaacaga tgagtctttc atgctgtgat ttgggattaa   4260

gatacaaggt gagcccagag atgaattggg cacacatttc ctggggcagg atgggagttg   4320

tggagggctg cacaacagcc ccactgcaag cctgggatat ccagaggcat cttcctcagc   4380

acccctaggt gcctgtgggc tgtgccttac atttaataaa aacttacaag gctg         4434


<210>  8472
<211>  650
<212>  PRT
<213>  Homosapiens

<400>  8472

Met Gln Glu Ser Leu Pro Ser Gly Ile Val Asn Phe Arg Glu Glu Ile 
1               5                   10                  15      


Cys Asp Met Asp Ser Ser Glu Ala Met Ser Leu Glu Ser Gln Glu Ser 
            20                  25                  30          


Pro Asn Glu Asn Phe Lys Thr Val Gly Pro Cys Leu Gly Asp Ser Lys 
        35                  40                  45              


Asn Val Ser Gln Glu Ser Leu Glu Thr Lys Glu Glu Lys Pro Glu Glu 
    50                  55                  60                  


Thr Pro Lys Met Glu Leu Ser Leu Glu Asn Val Thr Val Glu Gly Asn 
65                  70                  75                  80  


Ala Cys Lys Val Thr Glu Ser Asn Leu Glu Lys Ala Lys Thr Met Glu 
                85                  90                  95      


Leu Asn Val Gly Asn Glu Ala Ser Phe His Gly Gln Glu Arg Thr Lys 
            100                 105                 110         


Thr Gly Ile Ser Glu Glu Ala Ala Ile Glu Glu Asn Lys Arg Asn Asp 
        115                 120                 125             


Asp Ser Glu Ala Asp Thr Ala Lys Leu Asn Ala Lys Glu Val Ala Thr 
    130                 135                 140                 


Glu Glu Phe Asn Ser Asp Ile Ser Leu Ser Asp Asn Thr Thr Pro Val 
145                 150                 155                 160 


Lys Leu Asn Ala Gln Thr Glu Ile Ser Glu Gln Thr Ala Ala Gly Glu 
                165                 170                 175     


Leu Asp Gly Gly Asn Asp Val Ser Asp Leu His Ser Ser Glu Glu Thr 
            180                 185                 190         


Asn Thr Lys Met Lys Asn Asn Glu Glu Met Met Ile Gly Glu Ala Met 
        195                 200                 205             


Ala Glu Thr Gly His Asp Gly Glu Thr Glu Asn Glu Gly Ile Thr Thr 
    210                 215                 220                 


Lys Thr Ser Lys Pro Asp Glu Ala Glu Thr Asn Met Leu Thr Ala Glu 
225                 230                 235                 240 


Met Asp Asn Phe Val Cys Asp Thr Val Glu Met Ser Thr Glu Glu Gly 
                245                 250                 255     


Ile Ile Asp Ala Asn Lys Thr Glu Thr Asn Thr Glu Tyr Ser Lys Ser 
            260                 265                 270         


Glu Glu Lys Leu Asp Asn Asn Gln Met Val Met Glu Ser Asp Ile Leu 
        275                 280                 285             


Gln Glu Asp His His Thr Ser Gln Lys Val Glu Glu Pro Ser Gln Cys 
    290                 295                 300                 


Leu Ala Ser Gly Thr Ala Ile Ser Glu Leu Ile Ile Glu Asp Asn Asn 
305                 310                 315                 320 


Ala Ser Pro Gln Lys Leu Arg Glu Leu Asp Pro Ser Leu Val Ser Ala 
                325                 330                 335     


Asn Asp Ser Pro Ser Gly Met Gln Thr Arg Cys Val Trp Ser Pro Leu 
            340                 345                 350         


Ala Ser Pro Ser Thr Ser Ile Leu Lys Arg Gly Leu Lys Arg Ser Gln 
        355                 360                 365             


Glu Asp Glu Ile Ser Ser Pro Val Asn Lys Val Arg Arg Val Ser Phe 
    370                 375                 380                 


Ala Asp Pro Ile Tyr Gln Ala Gly Leu Ala Asp Asp Ile Asp Arg Arg 
385                 390                 395                 400 


Cys Ser Ile Val Arg Ser His Ser Ser Asn Ser Ser Pro Ile Gly Lys 
                405                 410                 415     


Ser Val Lys Thr Ser Pro Thr Thr Gln Ser Lys His Asn Thr Thr Ser 
            420                 425                 430         


Ala Lys Gly Phe Leu Ser Pro Gly Ser Arg Ser Pro Lys Phe Lys Ser 
        435                 440                 445             


Ser Lys Lys Cys Leu Ile Ser Glu Met Ala Lys Glu Ser Ile Pro Cys 
    450                 455                 460                 


Pro Thr Glu Ser Val Tyr Pro Pro Leu Val Asn Cys Val Ala Pro Val 
465                 470                 475                 480 


Asp Ile Ile Leu Pro Gln Ile Thr Ser Asn Met Trp Ala Arg Gly Leu 
                485                 490                 495     


Gly Gln Leu Ile Arg Ala Lys Asn Ile Lys Thr Ile Gly Asp Leu Ser 
            500                 505                 510         


Thr Leu Thr Ala Ser Glu Ile Lys Thr Leu Pro Ile Arg Ser Pro Lys 
        515                 520                 525             


Val Ser Asn Val Lys Lys Ala Leu Arg Ile Tyr His Glu Gln Gln Val 
    530                 535                 540                 


Lys Thr Arg Gly Leu Glu Glu Ile Pro Val Phe Asp Ile Ser Glu Lys 
545                 550                 555                 560 


Thr Val Asn Gly Ile Glu Asn Lys Ser Leu Ser Pro Asp Glu Glu Arg 
                565                 570                 575     


Leu Val Ser Asp Ile Ile Asp Pro Val Ala Leu Glu Ile Pro Leu Ser 
            580                 585                 590         


Lys Asn Leu Leu Ala Gln Ile Ser Ala Leu Ala Leu Gln Leu Asp Ser 
        595                 600                 605             


Glu Asp Leu His Asn Tyr Ser Gly Ser Gln Leu Phe Glu Met His Glu 
    610                 615                 620                 


Lys Leu Ser Cys Met Ala Asn Ser Val Ile Lys Asn Leu Gln Ser Arg 
625                 630                 635                 640 


Trp Arg Ser Pro Ser His Glu Asn Ser Ile 
                645                 650 


<210>  8473
<211>  2100
<212>  DNA
<213>  Homosapiens

<400>  8473
ttcatggaca agagagaacc aaaactggta tttctgaaga agcagcaata gaagaaaata     60

aaagaaatga tgactctgaa gcagacacag ctaaactgaa tgccaaagaa gtagcaactg    120

aggaatttaa ttcagatatt agtctttctg ataatactac acctgtaaaa ttgaatgctc    180

aaactgagat ttctgaacaa acagcagctg gggaactaga tggaggaaat gatgtatctg    240

atctacactc atctgaagaa acgaatacca aaatgaaaaa taatgaagaa atgatgatcg    300

gcgaggcaat ggctgaaact ggccatgatg gtgaaacaga gaatgagggc ataactacca    360

aaacctcaaa gcctgatgaa gctgaaacaa acatgttgac tgcagaaatg gacaactttg    420

tttgtgacac agttgaaatg agcactgaag aaggaatcat tgacgctaat aaaactgaaa    480

caaatactga gtatagtaaa tctgaagaaa aattagataa caatcaaatg gtaatggaaa    540

gtgatatttt acaggaagat caccatactt cacagaaagt ggaggaacca tcacagtgtc    600

tggcatctgg aacagctatc tctgagctaa taatagaaga caataatgca tctcctcaaa    660

aactaaggga acttgatcct tcacttgtgt cagcaaatga cagtcctagt ggcatgcaga    720

cacgctgtgt ctggtctcct ttggcttctc cgtctacgag cattttaaag agaggactaa    780

aaagatccca agaagatgaa atctcatcac ctgttaataa ggttcgccgt gtctcctttg    840

cagatccaat ataccaagca ggattggcag atgacattga tagacggtgc tctattgtta    900

ggtcccattc ttccaatagt tctcccatag gaaaaagtgt taaaacttct cctactacac    960

aatctaagat ttcagaaatg gccaaagaat ccataccatg cccaacagaa agtgtttacc   1020

caccattggt gaactgtgtg gcaccagttg acatcatttt acctcagatt acatcaaaca   1080

tgtgggcaag aggcctggga caactcatta gagctaagaa tataaaaact attggtgatt   1140

tgagtactct tacagcatct gaaataaaaa ctcttcctat ccgttctcca aaagtgtcca   1200

atgtaaaaaa ggctctcaga atatatcatg agcagcaggt gaagactcgt ggactagaag   1260

agattccagt ttttgatatt tctgaaaaaa cagtaaatgg aatagaaaat aaatctttgt   1320

cacctgatga agaaagactt gtctcagata taattgatcc tgttgcttta gaaattccat   1380

tatccaaaaa ccttctggca cagattagtg ctcttgctct tcagctggat tcagaagatc   1440

ttcataatta ttcaggaagc caactatttg aaatgcacga gaaactaagt tgtatggcaa   1500

actctgtaat aaaaaatcta cagtcacgtt ggagatcacc atcccatgaa aattctattt   1560

agtattttca gagaaaattg aaggtttttt taaacatcac tggatttctt gattgaggaa   1620

acaagttctg aaataatagc acaatttcaa agaagagact ctttgcaaag ttgataacat   1680

ttcaaaccct gaaggacagt gacttattat gtaagttcaa ttttgtaagt tcattatgta   1740

agatcctttt ttttttcata atatgtattc ttggctgcta tgcgtggttt ttcaggaaat   1800

ttaattatct tactgagatg tgaaagcaaa actagtaaca gaacttacat tttatttcat   1860

gctttcttaa acccgtgcat attctggtga aacatgtaaa atactttaag taaaattgaa   1920

catttttatt tgaatttttg ctgaactgat aaaggtgttt atatttttgt ttgttggttt   1980

gtttaattca tgtttgttgg gactgaggtt taggaagttt gttactggtt aaaaacctca   2040

aatgaaatgc gaaagaattt gaatttttcc tgcatatgtc aactttggac agctttcaag   2100


<210>  8474
<211>  429
<212>  PRT
<213>  Homosapiens

<400>  8474

Met Lys Asn Asn Glu Glu Met Met Ile Gly Glu Ala Met Ala Glu Thr 
1               5                   10                  15      


Gly His Asp Gly Glu Thr Glu Asn Glu Gly Ile Thr Thr Lys Thr Ser 
            20                  25                  30          


Lys Pro Asp Glu Ala Glu Thr Asn Met Leu Thr Ala Glu Met Asp Asn 
        35                  40                  45              


Phe Val Cys Asp Thr Val Glu Met Ser Thr Glu Glu Gly Ile Ile Asp 
    50                  55                  60                  


Ala Asn Lys Thr Glu Thr Asn Thr Glu Tyr Ser Lys Ser Glu Glu Lys 
65                  70                  75                  80  


Leu Asp Asn Asn Gln Met Val Met Glu Ser Asp Ile Leu Gln Glu Asp 
                85                  90                  95      


His His Thr Ser Gln Lys Val Glu Glu Pro Ser Gln Cys Leu Ala Ser 
            100                 105                 110         


Gly Thr Ala Ile Ser Glu Leu Ile Ile Glu Asp Asn Asn Ala Ser Pro 
        115                 120                 125             


Gln Lys Leu Arg Glu Leu Asp Pro Ser Leu Val Ser Ala Asn Asp Ser 
    130                 135                 140                 


Pro Ser Gly Met Gln Thr Arg Cys Val Trp Ser Pro Leu Ala Ser Pro 
145                 150                 155                 160 


Ser Thr Ser Ile Leu Lys Arg Gly Leu Lys Arg Ser Gln Glu Asp Glu 
                165                 170                 175     


Ile Ser Ser Pro Val Asn Lys Val Arg Arg Val Ser Phe Ala Asp Pro 
            180                 185                 190         


Ile Tyr Gln Ala Gly Leu Ala Asp Asp Ile Asp Arg Arg Cys Ser Ile 
        195                 200                 205             


Val Arg Ser His Ser Ser Asn Ser Ser Pro Ile Gly Lys Ser Val Lys 
    210                 215                 220                 


Thr Ser Pro Thr Thr Gln Ser Lys Ile Ser Glu Met Ala Lys Glu Ser 
225                 230                 235                 240 


Ile Pro Cys Pro Thr Glu Ser Val Tyr Pro Pro Leu Val Asn Cys Val 
                245                 250                 255     


Ala Pro Val Asp Ile Ile Leu Pro Gln Ile Thr Ser Asn Met Trp Ala 
            260                 265                 270         


Arg Gly Leu Gly Gln Leu Ile Arg Ala Lys Asn Ile Lys Thr Ile Gly 
        275                 280                 285             


Asp Leu Ser Thr Leu Thr Ala Ser Glu Ile Lys Thr Leu Pro Ile Arg 
    290                 295                 300                 


Ser Pro Lys Val Ser Asn Val Lys Lys Ala Leu Arg Ile Tyr His Glu 
305                 310                 315                 320 


Gln Gln Val Lys Thr Arg Gly Leu Glu Glu Ile Pro Val Phe Asp Ile 
                325                 330                 335     


Ser Glu Lys Thr Val Asn Gly Ile Glu Asn Lys Ser Leu Ser Pro Asp 
            340                 345                 350         


Glu Glu Arg Leu Val Ser Asp Ile Ile Asp Pro Val Ala Leu Glu Ile 
        355                 360                 365             


Pro Leu Ser Lys Asn Leu Leu Ala Gln Ile Ser Ala Leu Ala Leu Gln 
    370                 375                 380                 


Leu Asp Ser Glu Asp Leu His Asn Tyr Ser Gly Ser Gln Leu Phe Glu 
385                 390                 395                 400 


Met His Glu Lys Leu Ser Cys Met Ala Asn Ser Val Ile Lys Asn Leu 
                405                 410                 415     


Gln Ser Arg Trp Arg Ser Pro Ser His Glu Asn Ser Ile 
            420                 425                 


<210>  8475
<211>  2395
<212>  DNA
<213>  Homosapiens

<400>  8475
ttcatggaca agagagaacc aaaactggta tttctgaaga agcagcaata gaagaaaata     60

aaagaaatga tgactctgaa gcagacacag ctaaactgaa tgccaaagaa gtagcaactg    120

aggaatttaa ttcagatatt agtctttctg ataatactac acctgtaaaa ttgaatgctc    180

aaactgagat ttctgaacaa acagcagctg gggaactaga tggaggaaat gatgtatctg    240

atctacactc atctgaagaa acgaatacca aaatgaaaaa taatgaagaa atgatgatcg    300

gcgaggcaat ggctgaaact ggccatgatg gtgaaacaga gaatgagggc ataactacca    360

aaacctcaaa gcctgatgaa gctgaaacaa acatgttgac tgcagaaatg gacaactttg    420

tttgtgacac agttgaaatg agcactgaag aaggaatcat tgacgctaat aaaactgaaa    480

caaatactga gtatagtaaa tctgaagaaa aattagataa caatcaaatg gtaatggaaa    540

gtgatatttt acaggaagat caccatactt cacagaaagt ggaggaacca tcacagtgtc    600

tggcatctgg aacagctatc tctgagctaa taatagaaga caataatgca tctcctcaaa    660

aactaaggga acttgatcct tcacttgtgt cagcaaatga cagtcctagt ggcatgcaga    720

cacgctgtgt ctggtctcct ttggcttctc cgtctacgag cattttaaag agaggactaa    780

aaagatccca agaagatgaa atctcatcac ctgttaataa ggttcgccgt gtctcctttg    840

cagatccaat ataccaagca ggattggcag atgacattga tagacggtgc tctattgtta    900

ggtcccattc ttccaatagt tctcccatag gaaaaagtgt taaaacttct cctactacac    960

aatctaagat ttcagaaatg gccaaagaat ccataccatg cccaacagaa agtgtttacc   1020

caccattggt gaactgtgtg gcaccagttg acatcatttt acctcagatt acatcaaaca   1080

tgtgggcaag aggcctggga caactcatta gagctaagaa tataaaaact attggtgatt   1140

tgagtactct tacagcatct gaaataaaaa ctcttcctat ccgttctcca aaagtgtcca   1200

atgtaaaaaa ggctctcaga atatatcatg agcagcaggt gaagactcgt ggactagaag   1260

agattccagt ttttgatatt tctgaaaaaa cagtaaatgg aatagaaaat aaatctttgt   1320

cacctgatga agaaagactt gtctcagata taattgatcc tgttgcttta gaaattccat   1380

tatccaaaaa ccttctggca cagattagtg ctcttgctct tcagctggat tcagaagatc   1440

ttcataatta ttcaggaagc caactatttg aaatgcacga gaaactaagt tgtatggcaa   1500

actctgtaat aaaaaatcta cagtcacgtt ggagatcacc atcccatgaa aattctattt   1560

agtattttca gagaaaattg aaggtttttt taaacatcac tggatttctt gattgaggaa   1620

acaagttctg aaataatagc acaatttcaa agaagagact ctttgcaaag ttgataacat   1680

ttcaaaccct gaaggacagt gacttattat gtaagttcaa ttttgtaagt tcattatgta   1740

agatcctttt ttttttcata atatgtattc ttggctgcta tgcgtggttt ttcaggaaat   1800

ttaattatct tactgagatg tgaaagcaaa actagtaaca gaacttacat tttatttcat   1860

gctttcttaa acccgtgcat attctggtga aacatgtaaa atactttaag taaaattgaa   1920

catttttatt tgaatttttg ctgaactgat aaaggtgttt atatttttgt ttgttggttt   1980

gtttaattca tgtttgttgg gactgaggtt taggaagttt gttactggtt aaaaacctca   2040

aatgaaatgc gaaagaattt gaatttttcc tgcatatgtc aactttggac agctttcaag   2100

aaaaatgaga aaagtttcaa cttctggcgg ttaaaatatt aatgcagaat ttactaagat   2160

tttattcatt tgcattagca aatattcatg cagcagcagt tgactgaaaa tttattctta   2220

tgagacgtat agtattcatt tttaaatgca tgattgtaca ttatgtatag acgacaatgt   2280

ttttaattta taaatttcat tctttgttaa ttgcatgggt ttttctgcag cttattgtga   2340

ataccttggt tctgttcaat agaaacattt tgtatatatt aaatactgaa atatc        2395


<210>  8476
<211>  429
<212>  PRT
<213>  Homosapiens

<400>  8476

Met Lys Asn Asn Glu Glu Met Met Ile Gly Glu Ala Met Ala Glu Thr 
1               5                   10                  15      


Gly His Asp Gly Glu Thr Glu Asn Glu Gly Ile Thr Thr Lys Thr Ser 
            20                  25                  30          


Lys Pro Asp Glu Ala Glu Thr Asn Met Leu Thr Ala Glu Met Asp Asn 
        35                  40                  45              


Phe Val Cys Asp Thr Val Glu Met Ser Thr Glu Glu Gly Ile Ile Asp 
    50                  55                  60                  


Ala Asn Lys Thr Glu Thr Asn Thr Glu Tyr Ser Lys Ser Glu Glu Lys 
65                  70                  75                  80  


Leu Asp Asn Asn Gln Met Val Met Glu Ser Asp Ile Leu Gln Glu Asp 
                85                  90                  95      


His His Thr Ser Gln Lys Val Glu Glu Pro Ser Gln Cys Leu Ala Ser 
            100                 105                 110         


Gly Thr Ala Ile Ser Glu Leu Ile Ile Glu Asp Asn Asn Ala Ser Pro 
        115                 120                 125             


Gln Lys Leu Arg Glu Leu Asp Pro Ser Leu Val Ser Ala Asn Asp Ser 
    130                 135                 140                 


Pro Ser Gly Met Gln Thr Arg Cys Val Trp Ser Pro Leu Ala Ser Pro 
145                 150                 155                 160 


Ser Thr Ser Ile Leu Lys Arg Gly Leu Lys Arg Ser Gln Glu Asp Glu 
                165                 170                 175     


Ile Ser Ser Pro Val Asn Lys Val Arg Arg Val Ser Phe Ala Asp Pro 
            180                 185                 190         


Ile Tyr Gln Ala Gly Leu Ala Asp Asp Ile Asp Arg Arg Cys Ser Ile 
        195                 200                 205             


Val Arg Ser His Ser Ser Asn Ser Ser Pro Ile Gly Lys Ser Val Lys 
    210                 215                 220                 


Thr Ser Pro Thr Thr Gln Ser Lys Ile Ser Glu Met Ala Lys Glu Ser 
225                 230                 235                 240 


Ile Pro Cys Pro Thr Glu Ser Val Tyr Pro Pro Leu Val Asn Cys Val 
                245                 250                 255     


Ala Pro Val Asp Ile Ile Leu Pro Gln Ile Thr Ser Asn Met Trp Ala 
            260                 265                 270         


Arg Gly Leu Gly Gln Leu Ile Arg Ala Lys Asn Ile Lys Thr Ile Gly 
        275                 280                 285             


Asp Leu Ser Thr Leu Thr Ala Ser Glu Ile Lys Thr Leu Pro Ile Arg 
    290                 295                 300                 


Ser Pro Lys Val Ser Asn Val Lys Lys Ala Leu Arg Ile Tyr His Glu 
305                 310                 315                 320 


Gln Gln Val Lys Thr Arg Gly Leu Glu Glu Ile Pro Val Phe Asp Ile 
                325                 330                 335     


Ser Glu Lys Thr Val Asn Gly Ile Glu Asn Lys Ser Leu Ser Pro Asp 
            340                 345                 350         


Glu Glu Arg Leu Val Ser Asp Ile Ile Asp Pro Val Ala Leu Glu Ile 
        355                 360                 365             


Pro Leu Ser Lys Asn Leu Leu Ala Gln Ile Ser Ala Leu Ala Leu Gln 
    370                 375                 380                 


Leu Asp Ser Glu Asp Leu His Asn Tyr Ser Gly Ser Gln Leu Phe Glu 
385                 390                 395                 400 


Met His Glu Lys Leu Ser Cys Met Ala Asn Ser Val Ile Lys Asn Leu 
                405                 410                 415     


Gln Ser Arg Trp Arg Ser Pro Ser His Glu Asn Ser Ile 
            420                 425                 


<210>  8477
<211>  4214
<212>  DNA
<213>  Homosapiens

<400>  8477
ttcatggaca agagagaacc aaaactggta tttctgaaga agcagcaata gaagaaaata     60

aaagaaatga tgactctgaa gcagacacag ctaaactgaa tgccaaagaa gtagcaactg    120

aggaatttaa ttcagatatt agtctttctg ataatactac acctgtaaaa ttgaatgctc    180

aaactgagat ttctgaacaa acagcagctg gggaactaga tggaggaaat gatgtatctg    240

atctacactc atctgaagaa acgaatacca aaatgaaaaa taatgaagaa atgatgatcg    300

gcgaggcaat ggctgaaact ggccatgatg gtgaaacaga gaatgagggc ataactacca    360

aaacctcaaa gcctgatgaa gctgaaacaa acatgttgac tgcagaaatg gacaactttg    420

tttgtgacac agttgaaatg agcactgaag aaggaatcat tgacgctaat aaaactgaaa    480

caaatactga gtatagtaaa tctgaagaaa aattagataa caatcaaatg gtaatggaaa    540

gtgatatttt acaggaagat caccatactt cacagaaagt ggaggaacca tcacagtgtc    600

tggcatctgg aacagctatc tctgagctaa taatagaaga caataatgca tctcctcaaa    660

aactaaggga acttgatcct tcacttgtgt cagcaaatga cagtcctagt ggcatgcaga    720

cacgctgtgt ctggtctcct ttggcttctc cgtctacgag cattttaaag agaggactaa    780

aaagatccca agaagatgaa atctcatcac ctgttaataa ggttcgccgt gtctcctttg    840

cagatccaat ataccaagca ggattggcag atgacattga tagacggtgc tctattgtta    900

ggtcccattc ttccaatagt tctcccatag gaaaaagtgt taaaacttct cctactacac    960

aatctaagat ttcagaaatg gccaaagaat ccataccatg cccaacagaa agtgtttacc   1020

caccattggt gaactgtgtg gcaccagttg acatcatttt acctcagatt acatcaaaca   1080

tgtgggcaag aggcctggga caactcatta gagctaagaa tataaaaact attggtgatt   1140

tgagtactct tacagcatct gaaataaaaa ctcttcctat ccgttctcca aaagtgtcca   1200

atgtaaaaaa ggctctcaga atatatcatg agcagcaggt gaagactcgt ggactagaag   1260

agattccagt ttttgatatt tctgaaaaaa cagtaaatgg aatagaaaat aaatctttgt   1320

cacctgatga agaaagactt gtctcagata taattgatcc tgttgcttta gaaattccat   1380

tatccaaaaa ccttctggca cagattagtg ctcttgctct tcagctggat tcagaagatc   1440

ttcataatta ttcaggaagc caactatttg aaatgcacga gaaactaagt tgtatggcaa   1500

actctgtaat aaaaaatcta cagtcacgtt ggagatcacc atcccatgaa aattctattt   1560

agtattttca gagaaaattg aaggtttttt taaacatcac tggatttctt gattgaggaa   1620

acaagttctg aaataatagc acaatttcaa agaagagact ctttgcaaag ttgataacat   1680

ttcaaaccct gaaggacagt gacttattat gtaagttcaa ttttgtaagt tcattatgta   1740

agatcctttt ttttttcata atatgtattc ttggctgcta tgcgtggttt ttcaggaaat   1800

ttaattatct tactgagatg tgaaagcaaa actagtaaca gaacttacat tttatttcat   1860

gctttcttaa acccgtgcat attctggtga aacatgtaaa atactttaag taaaattgaa   1920

catttttatt tgaatttttg ctgaactgat aaaggtgttt atatttttgt ttgttggttt   1980

gtttaattca tgtttgttgg gactgaggtt taggaagttt gttactggtt aaaaacctca   2040

aatgaaatgc gaaagaattt gaatttttcc tgcatatgtc aactttggac agctttcaag   2100

aaaaatgaga aaagtttcaa cttctggcgg ttaaaatatt aatgcagaat ttactaagat   2160

tttattcatt tgcattagca aatattcatg cagcagcagt tgactgaaaa tttattctta   2220

tgagacgtat agtattcatt tttaaatgca tgattgtaca ttatgtatag acgacaatgt   2280

ttttaattta taaatttcat tctttgttaa ttgcatgggt ttttctgcag cttattgtga   2340

ataccttggt tctgttcaat agaaacattt tgtatatatt aaatactgaa atatcagtat   2400

cgacggtgga agtgcttcat gggcttgctg cacatatttg taggatactg tatctgcaaa   2460

tgcaacaaca aatagttttg tacttggtta acagtcttag ttaaaacatg agtttatttt   2520

ctaaaagtat ccagaataag taaaattata gaaataagaa aatgttacac aactttgctg   2580

ttcataccct taccttctta ctacttttgg tttggaggag ggtatcacca ctagaaagtg   2640

tgcctcctta agatttctta aaggaaagtt agtttcagta tttcacagca agttggacta   2700

caaaatctag agttgatctg ctttttaaac cttcatttaa aagcaaactt ggaagaaatt   2760

tgaaactgat gtttttaata tatgtctgtg ttgcctaggt tttctttttt taaagaggta   2820

tgtaattaaa acctttgtaa aatttgccaa ctaatattag tgcctgactt cccatatttg   2880

tttcatcttt ttaactgaca gtatatctca cttcttcttt gaatagaatg agtgagtgat   2940

ctcagttttc acattttatt cagaagctaa tccctactta gcaaggcaca cattctacag   3000

caagtcatag aaagtttaat ccttgtgcct ccttagctct cgtatattca gggatctcta   3060

taaaagttgg tgtctttttt catcatcata aattcatcat aatcacagat atttttgggt   3120

ctaagatatt catataccaa ggatggtttt gtaaagaatt ctgggatcat tgaattaagg   3180

attgtggctt gaagtaacta aagaaaaata ctaatttcct taaaaggaat tataattatg   3240

atttacattt tacatcatta atttcccaaa ttatatttaa ccgtaaggag gtgcacatga   3300

gtttttagca aacaggtatg aataagcagc tatgtatatg tgtttggggc agaggggagc   3360

agattacttt aacacacttc agaattaaaa tcagttcgtt tcatgactct gtgccttaac   3420

gtttgtgtga actaaacttg ctgattgaat gaaattcttg ggaagccgaa cagtaatagc   3480

agaaaatgtg accaaatgag tatcatgtac ttaaatcact gaattttata taagcacaag   3540

tattaatttt aaaaacatta tagtttaata aagctgcatt taaaaatatt tgggagcaaa   3600

gacaagcatg ctaaatcttc attttgctat ggctataagc atatattttt ggcaacttat   3660

ttgcaatatt cttgccttaa agtttcctgc aaatttcccc cttagtaatt cccgaatagc   3720

aaaacattaa tattccatga ttagctctac tgtgttgtct cactattaaa atggaattcg   3780

ttttttcaga tcttttctaa tggttaataa aacaaatgtc agatcataat aacactcaaa   3840

tgtgtcttaa ttgtcttatg catatttaag aagaaaaaac tagtggcata caggattgtc   3900

atgtagtatc tttttttttt tttgagacac agtcttgctc tgttgcctat gctggagtgc   3960

aatggtgcga tctcggttca ctgcaagctc tgcctcccag gtttacacca ttctcctgcc   4020

tcagcctccc aagtagctgg gactacaggt gcccgccacc atgcccggct aattttttat   4080

atttttagta gagaaggggt tcactgtgtt agccaggatg gtcttgatct gacctcgtga   4140

tccgcctgcc tcggcctccc aaagtgctgg gattacaggc gtgagccacc ccacctggcc   4200

attttctttt tttt                                                     4214


<210>  8478
<211>  429
<212>  PRT
<213>  Homosapiens

<400>  8478

Met Lys Asn Asn Glu Glu Met Met Ile Gly Glu Ala Met Ala Glu Thr 
1               5                   10                  15      


Gly His Asp Gly Glu Thr Glu Asn Glu Gly Ile Thr Thr Lys Thr Ser 
            20                  25                  30          


Lys Pro Asp Glu Ala Glu Thr Asn Met Leu Thr Ala Glu Met Asp Asn 
        35                  40                  45              


Phe Val Cys Asp Thr Val Glu Met Ser Thr Glu Glu Gly Ile Ile Asp 
    50                  55                  60                  


Ala Asn Lys Thr Glu Thr Asn Thr Glu Tyr Ser Lys Ser Glu Glu Lys 
65                  70                  75                  80  


Leu Asp Asn Asn Gln Met Val Met Glu Ser Asp Ile Leu Gln Glu Asp 
                85                  90                  95      


His His Thr Ser Gln Lys Val Glu Glu Pro Ser Gln Cys Leu Ala Ser 
            100                 105                 110         


Gly Thr Ala Ile Ser Glu Leu Ile Ile Glu Asp Asn Asn Ala Ser Pro 
        115                 120                 125             


Gln Lys Leu Arg Glu Leu Asp Pro Ser Leu Val Ser Ala Asn Asp Ser 
    130                 135                 140                 


Pro Ser Gly Met Gln Thr Arg Cys Val Trp Ser Pro Leu Ala Ser Pro 
145                 150                 155                 160 


Ser Thr Ser Ile Leu Lys Arg Gly Leu Lys Arg Ser Gln Glu Asp Glu 
                165                 170                 175     


Ile Ser Ser Pro Val Asn Lys Val Arg Arg Val Ser Phe Ala Asp Pro 
            180                 185                 190         


Ile Tyr Gln Ala Gly Leu Ala Asp Asp Ile Asp Arg Arg Cys Ser Ile 
        195                 200                 205             


Val Arg Ser His Ser Ser Asn Ser Ser Pro Ile Gly Lys Ser Val Lys 
    210                 215                 220                 


Thr Ser Pro Thr Thr Gln Ser Lys Ile Ser Glu Met Ala Lys Glu Ser 
225                 230                 235                 240 


Ile Pro Cys Pro Thr Glu Ser Val Tyr Pro Pro Leu Val Asn Cys Val 
                245                 250                 255     


Ala Pro Val Asp Ile Ile Leu Pro Gln Ile Thr Ser Asn Met Trp Ala 
            260                 265                 270         


Arg Gly Leu Gly Gln Leu Ile Arg Ala Lys Asn Ile Lys Thr Ile Gly 
        275                 280                 285             


Asp Leu Ser Thr Leu Thr Ala Ser Glu Ile Lys Thr Leu Pro Ile Arg 
    290                 295                 300                 


Ser Pro Lys Val Ser Asn Val Lys Lys Ala Leu Arg Ile Tyr His Glu 
305                 310                 315                 320 


Gln Gln Val Lys Thr Arg Gly Leu Glu Glu Ile Pro Val Phe Asp Ile 
                325                 330                 335     


Ser Glu Lys Thr Val Asn Gly Ile Glu Asn Lys Ser Leu Ser Pro Asp 
            340                 345                 350         


Glu Glu Arg Leu Val Ser Asp Ile Ile Asp Pro Val Ala Leu Glu Ile 
        355                 360                 365             


Pro Leu Ser Lys Asn Leu Leu Ala Gln Ile Ser Ala Leu Ala Leu Gln 
    370                 375                 380                 


Leu Asp Ser Glu Asp Leu His Asn Tyr Ser Gly Ser Gln Leu Phe Glu 
385                 390                 395                 400 


Met His Glu Lys Leu Ser Cys Met Ala Asn Ser Val Ile Lys Asn Leu 
                405                 410                 415     


Gln Ser Arg Trp Arg Ser Pro Ser His Glu Asn Ser Ile 
            420                 425                 


<210>  8479
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  8479
ggaattcaca acacaccgtt ggacatgatg tcaattgttc aagccaagaa atgccaggtc     60

ctggttagcg acattgatta tcgcaattat ctgcaccagt ggacgtgtct gccagatcag    120

aacgatgtga tccaggccaa gaaagcctac gacctgcaga gcgataactt gtacaagtca    180

gacctggaat ggctgaaggg tattggatgg ttgccagagg gttctgtgga agtgatgaga    240

gtgaagaatg cccagaatct cttgaatgaa aggctgtatc gtataaagcc tgaggccctc    300

aaattcacca gcattgttga caccccggaa gtaatccagg caaagatcaa tgctgtacag    360

atcagtgagc cattgtatcg cgatgcctgg gagaaagaga aggctaatgt gaacgtgcca    420

gctgacactc ccctgatgct gcaatccaaa atcaatgccc tgcagatcag caataaacgc    480

tatcagcaag cttgggaaga tgtcaagatg actggttatg acctgcgagc agatgccatt    540

gggatccagc atgccaaggc ttccagggat attgccagtg actatctgta caaaactgct    600

tatgagaaac agaaaggcca ttacattggc tgtcgcagcg ccaaggaaga ccctaaactg    660

gtttgggcag caaatgtgtt gaagatgcag aatgacaggc tgtacaaaaa ggcctacaac    720

gaccacaaag ccaagatctc catccctgtg gacatggtgt ccatcagcgc tgccaaagaa    780

ggtcaggcac tggcaagtga tgtggactat cgccattacc tgcaccgctg gtcttgcttt    840

cccgaccaga atgatgtgat ccaagccagg aaagcctacg acctacagag cgacgccctc    900

tacaaggctg acttggagtg gttgcgtggc attggctgga tgccccaagg gtctcctgaa    960

gtgttgagag tcaaaaacgc ccagaatatc ttttgtgaca gtgtctatcg gacgcctgtg   1020

gtgaacctta agtacacaag cattgttgac acacctgaag tggtccttgc taaatcaaat   1080

gctgaaaata ttagtattcc aaagtacaga gaggtttggg acaaggataa aacttcaata   1140

cacataatgc cagatactcc agaaattaat ctcgctagag caaatgctct taatgtgagc   1200

aataaacttt accgtgaggg ctgggatgaa atgaaggcgg gctgtgatgt ccggctggat   1260

gccatcccca tccaggctgc caaggcctcc agggagattg ccagtgacta taaatataag   1320

cttgaccatg agaagcagaa gggacactac gtgggcaccc tcacagccag ggatgacaac   1380

aagatccgct gggccctcat agctgacaag ctccagaatg aacgagagta ccggctggac   1440

tgggccaaat ggaaggccaa gatccagagc cctgtggaca tgctttccat cctgcactct   1500

aaaaattccc aggctctggt cagtgacatg gattaccgca attacctgca ccagtggacc   1560

tgcatgcccg accagaacga tgtgattcag gccaagaagg cctacgaact gcagagcgat   1620

aatgtttaca aggctgactt ggaatggttg cgtggaattg ggtggatgcc aaatgactcc   1680

gtgtccgtca atcatgccaa acatgccgcg gacatcttca gtgagaaaaa atatcgcaca   1740

aaaatagaaa ctctcaactt tacgcctgtg gatgacagag ttgattatgt gacagcgaaa   1800

caaagtggcg agatcctcga tgatattaaa taccggaaag actggaatgc caccaaatca   1860

aagtacaccc tcacagaaac ccccctgctg cacactgccc aggaggctgc taggatactg   1920

gaccagtatc tctacaagga aggctgggag agacaaaaag ccacaggtta cattttgcct   1980

ccagatgctg tgccatttgt tcatgcccat cactgcaatg acgttcagag tgagctgaaa   2040

tacaaagctg aacatgtgaa gcaaaaaggt cattatgttg gtgtcccgac gatgagagat   2100

gatcctaagc tggtttggtt tgagcatgca ggccagattc agaatgagag actatacaaa   2160

gaggactatc acaaaacaaa ggccaaaatc aatatacctg ctgatatggt gtcagtcttg   2220

gccgccaagc aggggcagac ccttgtcagt gatattgatt atcgtaatta cttgcaccaa   2280

tggatgtgtc atcctgacca gaacgatgtt attcaggcaa gaaaggccta tgacctacag   2340

agtgataatg tctacagagc tgacctggag tggctccgag gcattggctg gatcccactg   2400

gattctgtgg accatgtaag ggttactaag aaccaggaaa tgatgagtca gatcaaatat   2460

aagaaaaatg cccttgaaaa ctatcctaac tttagaagtg tggtggatcc tccagagatt   2520

gttttagcca agattaattc tgtcaatcaa agtgatgtaa aatataaaga aacatttaat   2580

aaagcaaagg gcaaatatac gttttcacca gatacaccac atatctccca ctccaaagac   2640

atgggaaaac tctacagtac tatactgtat aaaggggcgt gggagggcac caaggcctat   2700

ggctacaccc tggatgagcg ctacattccc attgttggag ccaagcatgc tgatctggtg   2760

aacagtgagc ttaaatacaa agagacatat gagaagcaga aaggtcacta cctggctgga   2820

aaagtgatcg gtgaattccc tggtgtggtt cactgtctgg atttccaaaa gatgaggagt   2880

gcgttgaact acagaaaaca ttatgaggat accaaagcaa atgttcatat ccccaatgac   2940

atgatgaatc acgtgctggc taaaaggtgc cagtacatcc tcagtgacct ggagtatcga   3000

cactatttcc accagtggac gtctcttctg gaagaaccca atgttatacg cgtccgaaac   3060

gcccaggaga tcttgagtga taatgtgtat aaagatgacc tgaattggtt gaaaggcatt   3120

ggttgctacg tttgggatac accccaaatc ctccatgcca agaaatcata cgaccttcag   3180

agtcagctac aatatacagc agcaggtaaa gaaaatctac aaaactataa tctggtcaca   3240

gacacgcccc tctatgtgac tgctgttcag agtggcatta atgccagtga ggtaaaatat   3300

aaagaaaatt atcatcagat taaggacaaa tacacaacag ttctagaaac agtggattat   3360

gacagaacca gaaacctgaa gaatctttac agcagtaacc tgtacaagga ggcctgggat   3420

agagtgaaag ccaccagcta catcctgcct tccagcacct tgtccctgac acacgccaag   3480

aaccagaagc atctggccag ccatatcaaa tatcgggaag aatatgaaaa gttcaaagct   3540

ctttatacgt taccaagaag tgttgacgat gatccgaaca cagcacggtg cctccgagtt   3600

ggcaagctta acatcgatcg cctgtacaga tcagtttatg aaaagaacaa gatgaaaatc   3660

cacatcgtgc ccgacatggt agagatggtt actgccaagg attcccagaa gaaagtcagt   3720

gagattgatt accgcctgcg cctccacgaa tggatttgcc accccgactt gcaagtcaat   3780

gatcacgtca ggaaagtcac agatcagatc agcgatattg tatacaagga tgacctcaac   3840

tggctgaaag gcattggttg ctacgtctgg gacactcctg aaatcctcca tgccaagcat   3900

gcttatgatc tacgtgatga tatcaagtat aaagctcaca tgttgaaaac aaggaatgac   3960

tacaagcttg tcacagatac accagtctac gtgcaggctg tcaaaagtgg gaaacagcta   4020

agtgacgctg tctaccacta tgactatgtg cacagtgtca gaggcaaagt ggctccaact   4080

accaaaaccg tggatctgga ccgggccctt catgcataca agctccagag ttcgaatcta   4140

tacaaaacca gcctgcgcac cctgcccact ggatatagac ttccaggtga cactcctcac   4200

ttcaaacaca tcaaggacac ccgttacatg agcagttatt tcaagtacaa agaagcctat   4260

gaacacacca aggcatatgg gtatacactt ggccccaaag atgttccatt tgtccacgtc   4320

cggagagtca acaatgttac cagcgagaga ctgtatcggg aattgtacca caaactgaaa   4380

gacaagatcc atacaactcc cgatacccct gagatccgcc aagtcaagaa gacacaagag   4440

gctgtcagtg agttgatcta caaatcagac ttcttcaaga tgcagggcca catgatctct   4500

ctgccataca caccccaagt gatccattgc cgctatgtgg gagacatcac cagtgatatt   4560

aaatacaaag aggacttgca ggtcctgaag ggatttggct gcttcctgta tgacactcct   4620

gacatggtcc gctcccggca cctgcggaag ctctggtcta attacctata cactgataag   4680

gcaaggaaga tgcgagacaa atacaaagtg gtgcttgaca ctccagaata cagaaaagtg   4740

caagaactga agacacatct gagtgagctg gtctacagag ctgcaggcaa gaagcagaag   4800

tcaatcttta cttcagttcc tgatactcct gatcttttaa gagccaagcg agggcagaag   4860

cttcagagtc agtatctgta tgttgaactt gccaccaaag agagacccca tcatcacgct   4920

ggaaaccaga ccacagcctt gaagcatgct aaagacgtga aggacatggt cagtgagaaa   4980

aagtacaaga ttcaatatga aaagatgaaa gacaagtaca ctccggttcc agatacgcca   5040

atcctcatca gagccaagag ggcttactgg aatgccagtg atctacgcta caaagaaaca   5100

tttcaaaaga ccaaagggaa ataccacacg gtgaaagatg ccctagacat tgtctatcat   5160

cgcaaagtca cagatgacat cagtaaaata aaatacaagg agaactacat gagccagttg   5220

ggtatctgga ggtccattcc tgatcgtcca gagcatttcc accaccgagc agtcactgac   5280

acagtcagtg atgtaaaata taaagaagac ttgacttggc ttaaaggcat tggttgctat   5340

gcctatgata cccctgattt cactctggct gaaaagaaca agactctcta cagcaagtat   5400

aagtataaag aagtatttga aaggacaaag tcagatttca agtatgttgc cgactctccg   5460

atcaataggc atttcaagta tgcaactcaa ttgatgaatg agaaaaaata cagagctgat   5520

tatgagcagc ggaaagataa ataccacctg gtagtcgatg agcctagaca tctgctggct   5580

aagaccgcag gcgaccagat cagtcagatc aaatacagga aaaactatga aaaatcaaag   5640

gacaaattta cctcaattgt ggatactcca gaacacctgc gtactacaaa agtcaacaaa   5700

caaatcagcg atatccttta taaattggaa tacaacaagg ccaaacccag aggctacacc   5760

acaatccacg acacacccat gttgctgcat gtccgcaagg ttaaagatga agtcagtgat   5820

ctgaaataca aagaagtata ccaaagaaat aaatccaact gcaccattga gccagatgct   5880

gttcatatca aagcagccaa ggacgcctac aaagtcaaca ccaatctgga ctataagaaa   5940

cagtacgaag ccaacaaagc ccactggaag tggactcctg accgaccgga cttcctccag   6000

gctgccaagt catccctgca gcaaagcgat tttgaatata agctggaccg ggagttcctc   6060

aagggttgca agctttctgt cactgatgac aaaaacacgg tgctcgccct caggaatact   6120

ttaatagaaa gtgatctgaa atacaaagag aaacatgtca aggaaagagg aacctgccat   6180

gccgtacctg acacgcctca gatcctgctg gcgaagactg tcagcaacct ggtgtctgag   6240

aacaagtaca aggaccatgt caagaagcac ttggcacagg gctcatacac aacactacca   6300

gagacccggg acactgttca cgtcaaggaa gtgaccaagc atgtcagtga tacaaattac   6360

aaaaagaagt ttgtcaagga gaaaggaaaa tccaactact ccatcatgct ggagccacca   6420

gaggtgaaac atgctatgga agtggccaag aagcaaagtg atgtcgctta cagaaaagat   6480

gccaaagaga acctgcatta caccacagtg gctgatcgac cagacatcaa gaaggccaca   6540

caggcagcca aacaggccag tgaggtggag tacagagcca agcaccgcaa ggaaggcagc   6600

catggcttaa gcatgctcgg tcgcccagac atagaaatgg ccaagaaggc agccaagctg   6660

agcagccagg ttaaataccg agaaaatttc gataaagaaa agggcaagac accaaaatac   6720

aatccaaaag acagccagct ctacaaagtc atgaaagatg ctaataatct tgcaagtgag   6780

gttaaataca aggctgacct gaagaaactt cacaaacccg tgactgacat gaaggagtct   6840

ctgatcatga atcatgtcct gaatacaagc caacttgcca gttcttacca gtacaagaag   6900

aagtatgaga agagtaaagg ccactaccac accatacccg ataatctgga gcagcttcac   6960

ctaaaagagg ccacagaatt acagagtata gtgaaataca aagaaaagta tgaaaaggaa   7020

cgaggaaaac ccatgctgga ctttgaaaca ccaacgtaca tcactgccaa agagtctcag   7080

cagatgcaga gtgggaaaga atataggaaa gattatgaag agtccattaa aggcagaaac   7140

ctgactggcc tggaggtcac gccagctttg ttacatgtca aatatgcaac taaaatagca   7200

agcgagaaag agtacaggaa agatctagag gaaagcatcc gtgggaaggg cctcactgaa   7260

atggaagata cacctgacat gctaagagca aagaatgcca ctcaaatcct caatgagaaa   7320

gaatataagc gagacctgga actggaagtc aaaggaagag gcctgaatgc catggccaat   7380

gaaactccgg attttatgag ggccaggaat gctactgata ttgccagtca gattaagtat   7440

aagcaatcag cagaaatgga gaaagccaat ttcacttctg tggttgatac tccagagatc   7500

attcatgccc aacaagtcaa gaatctttca agccagaaaa agtacaagga agatgctgag   7560

aagtccatgt cgtattatga gactgttttg gacaccccag agatacagag agtccgggag   7620

aaccaaaaga acttcagcct tctccaatac cagtgtgacc ttaaaaacag taaaggaaaa   7680

attacagttg ttcaagacac gccagaaata ctgcgtgtaa aagaaaatca gaagaatttc   7740

agctcggttt tatataaaga ggatgtctca ccaggaacgg ctatcggaaa gacacctgag   7800

atgatgagag tgaaacaaac acaggaccac attagctcgg tgaagtataa ggaagcaata   7860

ggacaaggaa ctccaatccc tgacctgcct gaagtgaaac gtgtgaagga gacgcagaag   7920

cacattagct cggttatgta caaagaaaac ttgggaacag gcattccaac cactgtgact   7980

ccagagattg agagagtcaa acgcaatcaa gagaacttta gctcggtgtt atacaaagaa   8040

aacatgggca agggaactcc tttagctgtc actcccgaga tggagcgagt caaacacaat   8100

caagaaaata ttagctcggt tttgtacaaa gaaaatgtgg ggaaagccac cgcaacccct   8160

gtcactcctg agatgcagag agtcaaacgc aa                                 8192


<210>  8480
<211>  2999
<212>  PRT
<213>  Homosapiens

<400>  8480

Met Met Ser Ile Val Gln Ala Lys Lys Cys Gln Val Leu Val Ser Asp 
1               5                   10                  15      


Ile Asp Tyr Arg Asn Tyr Leu His Gln Trp Thr Cys Leu Pro Asp Gln 
            20                  25                  30          


Asn Asp Val Ile Gln Ala Lys Lys Ala Tyr Asp Leu Gln Ser Asp Asn 
        35                  40                  45              


Leu Tyr Lys Ser Asp Leu Glu Trp Leu Lys Gly Ile Gly Trp Leu Pro 
    50                  55                  60                  


Glu Gly Ser Val Glu Val Met Arg Val Lys Asn Ala Gln Asn Leu Leu 
65                  70                  75                  80  


Asn Glu Arg Leu Tyr Arg Ile Lys Pro Glu Ala Leu Lys Phe Thr Ser 
                85                  90                  95      


Ile Val Asp Thr Pro Glu Val Ile Gln Ala Lys Ile Asn Ala Val Gln 
            100                 105                 110         


Ile Ser Glu Pro Leu Tyr Arg Asp Ala Trp Glu Lys Glu Lys Ala Asn 
        115                 120                 125             


Val Asn Val Pro Ala Asp Thr Pro Leu Met Leu Gln Ser Lys Ile Asn 
    130                 135                 140                 


Ala Leu Gln Ile Ser Asn Lys Arg Tyr Gln Gln Ala Trp Glu Asp Val 
145                 150                 155                 160 


Lys Met Thr Gly Tyr Asp Leu Arg Ala Asp Ala Ile Gly Ile Gln His 
                165                 170                 175     


Ala Lys Ala Ser Arg Asp Ile Ala Ser Asp Tyr Leu Tyr Lys Thr Ala 
            180                 185                 190         


Tyr Glu Lys Gln Lys Gly His Tyr Ile Gly Cys Arg Ser Ala Lys Glu 
        195                 200                 205             


Asp Pro Lys Leu Val Trp Ala Ala Asn Val Leu Lys Met Gln Asn Asp 
    210                 215                 220                 


Arg Leu Tyr Lys Lys Ala Tyr Asn Asp His Lys Ala Lys Ile Ser Ile 
225                 230                 235                 240 


Pro Val Asp Met Val Ser Ile Ser Ala Ala Lys Glu Gly Gln Ala Leu 
                245                 250                 255     


Ala Ser Asp Val Asp Tyr Arg His Tyr Leu His Arg Trp Ser Cys Phe 
            260                 265                 270         


Pro Asp Gln Asn Asp Val Ile Gln Ala Arg Lys Ala Tyr Asp Leu Gln 
        275                 280                 285             


Ser Asp Ala Leu Tyr Lys Ala Asp Leu Glu Trp Leu Arg Gly Ile Gly 
    290                 295                 300                 


Trp Met Pro Gln Gly Ser Pro Glu Val Leu Arg Val Lys Asn Ala Gln 
305                 310                 315                 320 


Asn Ile Phe Cys Asp Ser Val Tyr Arg Thr Pro Val Val Asn Leu Lys 
                325                 330                 335     


Tyr Thr Ser Ile Val Asp Thr Pro Glu Val Val Leu Ala Lys Ser Asn 
            340                 345                 350         


Ala Glu Asn Ile Ser Ile Pro Lys Tyr Arg Glu Val Trp Asp Lys Asp 
        355                 360                 365             


Lys Thr Ser Ile His Ile Met Pro Asp Thr Pro Glu Ile Asn Leu Ala 
    370                 375                 380                 


Arg Ala Asn Ala Leu Asn Val Ser Asn Lys Leu Tyr Arg Glu Gly Trp 
385                 390                 395                 400 


Asp Glu Met Lys Ala Gly Cys Asp Val Arg Leu Asp Ala Ile Pro Ile 
                405                 410                 415     


Gln Ala Ala Lys Ala Ser Arg Glu Ile Ala Ser Asp Tyr Lys Tyr Lys 
            420                 425                 430         


Leu Asp His Glu Lys Gln Lys Gly His Tyr Val Gly Thr Leu Thr Ala 
        435                 440                 445             


Arg Asp Asp Asn Lys Ile Arg Trp Ala Leu Ile Ala Asp Lys Leu Gln 
    450                 455                 460                 


Asn Glu Arg Glu Tyr Arg Leu Asp Trp Ala Lys Trp Lys Ala Lys Ile 
465                 470                 475                 480 


Gln Ser Pro Val Asp Met Leu Ser Ile Leu His Ser Lys Asn Ser Gln 
                485                 490                 495     


Ala Leu Val Ser Asp Met Asp Tyr Arg Asn Tyr Leu His Gln Trp Thr 
            500                 505                 510         


Cys Met Pro Asp Gln Asn Asp Val Ile Gln Ala Lys Lys Ala Tyr Glu 
        515                 520                 525             


Leu Gln Ser Asp Asn Val Tyr Lys Ala Asp Leu Glu Trp Leu Arg Gly 
    530                 535                 540                 


Ile Gly Trp Met Pro Asn Asp Ser Val Ser Val Asn His Ala Lys His 
545                 550                 555                 560 


Ala Ala Asp Ile Phe Ser Glu Lys Lys Tyr Arg Thr Lys Ile Glu Thr 
                565                 570                 575     


Leu Asn Phe Thr Pro Val Asp Asp Arg Val Asp Tyr Val Thr Ala Lys 
            580                 585                 590         


Gln Ser Gly Glu Ile Leu Asp Asp Ile Lys Tyr Arg Lys Asp Trp Asn 
        595                 600                 605             


Ala Thr Lys Ser Lys Tyr Thr Leu Thr Glu Thr Pro Leu Leu His Thr 
    610                 615                 620                 


Ala Gln Glu Ala Ala Arg Ile Leu Asp Gln Tyr Leu Tyr Lys Glu Gly 
625                 630                 635                 640 


Trp Glu Arg Gln Lys Ala Thr Gly Tyr Ile Leu Pro Pro Asp Ala Val 
                645                 650                 655     


Pro Phe Val His Ala His His Cys Asn Asp Val Gln Ser Glu Leu Lys 
            660                 665                 670         


Tyr Lys Ala Glu His Val Lys Gln Lys Gly His Tyr Val Gly Val Pro 
        675                 680                 685             


Thr Met Arg Asp Asp Pro Lys Leu Val Trp Phe Glu His Ala Gly Gln 
    690                 695                 700                 


Ile Gln Asn Glu Arg Leu Tyr Lys Glu Asp Tyr His Lys Thr Lys Ala 
705                 710                 715                 720 


Lys Ile Asn Ile Pro Ala Asp Met Val Ser Val Leu Ala Ala Lys Gln 
                725                 730                 735     


Gly Gln Thr Leu Val Ser Asp Ile Asp Tyr Arg Asn Tyr Leu His Gln 
            740                 745                 750         


Trp Met Cys His Pro Asp Gln Asn Asp Val Ile Gln Ala Arg Lys Ala 
        755                 760                 765             


Tyr Asp Leu Gln Ser Asp Asn Val Tyr Arg Ala Asp Leu Glu Trp Leu 
    770                 775                 780                 


Arg Gly Ile Gly Trp Ile Pro Leu Asp Ser Val Asp His Val Arg Val 
785                 790                 795                 800 


Thr Lys Asn Gln Glu Met Met Ser Gln Ile Lys Tyr Lys Lys Asn Ala 
                805                 810                 815     


Leu Glu Asn Tyr Pro Asn Phe Arg Ser Val Val Asp Pro Pro Glu Ile 
            820                 825                 830         


Val Leu Ala Lys Ile Asn Ser Val Asn Gln Ser Asp Val Lys Tyr Lys 
        835                 840                 845             


Glu Thr Phe Asn Lys Ala Lys Gly Lys Tyr Thr Phe Ser Pro Asp Thr 
    850                 855                 860                 


Pro His Ile Ser His Ser Lys Asp Met Gly Lys Leu Tyr Ser Thr Ile 
865                 870                 875                 880 


Leu Tyr Lys Gly Ala Trp Glu Gly Thr Lys Ala Tyr Gly Tyr Thr Leu 
                885                 890                 895     


Asp Glu Arg Tyr Ile Pro Ile Val Gly Ala Lys His Ala Asp Leu Val 
            900                 905                 910         


Asn Ser Glu Leu Lys Tyr Lys Glu Thr Tyr Glu Lys Gln Lys Gly His 
        915                 920                 925             


Tyr Leu Ala Gly Lys Val Ile Gly Glu Phe Pro Gly Val Val His Cys 
    930                 935                 940                 


Leu Asp Phe Gln Lys Met Arg Ser Ala Leu Asn Tyr Arg Lys His Tyr 
945                 950                 955                 960 


Glu Asp Thr Lys Ala Asn Val His Ile Pro Asn Asp Met Met Asn His 
                965                 970                 975     


Val Leu Ala Lys Arg Cys Gln Tyr Ile Leu Ser Asp Leu Glu Tyr Arg 
            980                 985                 990         


His Tyr Phe His Gln Trp Thr Ser  Leu Leu Glu Glu Pro  Asn Val Ile 
        995                 1000                 1005             


Arg Val  Arg Asn Ala Gln Glu  Ile Leu Ser Asp Asn  Val Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Leu Asn Trp Leu Lys  Gly Ile Gly Cys Tyr  Val Trp Asp 
    1025                 1030                 1035             


Thr Pro  Gln Ile Leu His Ala  Lys Lys Ser Tyr Asp  Leu Gln Ser 
    1040                 1045                 1050             


Gln Leu  Gln Tyr Thr Ala Ala  Gly Lys Glu Asn Leu  Gln Asn Tyr 
    1055                 1060                 1065             


Asn Leu  Val Thr Asp Thr Pro  Leu Tyr Val Thr Ala  Val Gln Ser 
    1070                 1075                 1080             


Gly Ile  Asn Ala Ser Glu Val  Lys Tyr Lys Glu Asn  Tyr His Gln 
    1085                 1090                 1095             


Ile Lys  Asp Lys Tyr Thr Thr  Val Leu Glu Thr Val  Asp Tyr Asp 
    1100                 1105                 1110             


Arg Thr  Arg Asn Leu Lys Asn  Leu Tyr Ser Ser Asn  Leu Tyr Lys 
    1115                 1120                 1125             


Glu Ala  Trp Asp Arg Val Lys  Ala Thr Ser Tyr Ile  Leu Pro Ser 
    1130                 1135                 1140             


Ser Thr  Leu Ser Leu Thr His  Ala Lys Asn Gln Lys  His Leu Ala 
    1145                 1150                 1155             


Ser His  Ile Lys Tyr Arg Glu  Glu Tyr Glu Lys Phe  Lys Ala Leu 
    1160                 1165                 1170             


Tyr Thr  Leu Pro Arg Ser Val  Asp Asp Asp Pro Asn  Thr Ala Arg 
    1175                 1180                 1185             


Cys Leu  Arg Val Gly Lys Leu  Asn Ile Asp Arg Leu  Tyr Arg Ser 
    1190                 1195                 1200             


Val Tyr  Glu Lys Asn Lys Met  Lys Ile His Ile Val  Pro Asp Met 
    1205                 1210                 1215             


Val Glu  Met Val Thr Ala Lys  Asp Ser Gln Lys Lys  Val Ser Glu 
    1220                 1225                 1230             


Ile Asp  Tyr Arg Leu Arg Leu  His Glu Trp Ile Cys  His Pro Asp 
    1235                 1240                 1245             


Leu Gln  Val Asn Asp His Val  Arg Lys Val Thr Asp  Gln Ile Ser 
    1250                 1255                 1260             


Asp Ile  Val Tyr Lys Asp Asp  Leu Asn Trp Leu Lys  Gly Ile Gly 
    1265                 1270                 1275             


Cys Tyr  Val Trp Asp Thr Pro  Glu Ile Leu His Ala  Lys His Ala 
    1280                 1285                 1290             


Tyr Asp  Leu Arg Asp Asp Ile  Lys Tyr Lys Ala His  Met Leu Lys 
    1295                 1300                 1305             


Thr Arg  Asn Asp Tyr Lys Leu  Val Thr Asp Thr Pro  Val Tyr Val 
    1310                 1315                 1320             


Gln Ala  Val Lys Ser Gly Lys  Gln Leu Ser Asp Ala  Val Tyr His 
    1325                 1330                 1335             


Tyr Asp  Tyr Val His Ser Val  Arg Gly Lys Val Ala  Pro Thr Thr 
    1340                 1345                 1350             


Lys Thr  Val Asp Leu Asp Arg  Ala Leu His Ala Tyr  Lys Leu Gln 
    1355                 1360                 1365             


Ser Ser  Asn Leu Tyr Lys Thr  Ser Leu Arg Thr Leu  Pro Thr Gly 
    1370                 1375                 1380             


Tyr Arg  Leu Pro Gly Asp Thr  Pro His Phe Lys His  Ile Lys Asp 
    1385                 1390                 1395             


Thr Arg  Tyr Met Ser Ser Tyr  Phe Lys Tyr Lys Glu  Ala Tyr Glu 
    1400                 1405                 1410             


His Thr  Lys Ala Tyr Gly Tyr  Thr Leu Gly Pro Lys  Asp Val Pro 
    1415                 1420                 1425             


Phe Val  His Val Arg Arg Val  Asn Asn Val Thr Ser  Glu Arg Leu 
    1430                 1435                 1440             


Tyr Arg  Glu Leu Tyr His Lys  Leu Lys Asp Lys Ile  His Thr Thr 
    1445                 1450                 1455             


Pro Asp  Thr Pro Glu Ile Arg  Gln Val Lys Lys Thr  Gln Glu Ala 
    1460                 1465                 1470             


Val Ser  Glu Leu Ile Tyr Lys  Ser Asp Phe Phe Lys  Met Gln Gly 
    1475                 1480                 1485             


His Met  Ile Ser Leu Pro Tyr  Thr Pro Gln Val Ile  His Cys Arg 
    1490                 1495                 1500             


Tyr Val  Gly Asp Ile Thr Ser  Asp Ile Lys Tyr Lys  Glu Asp Leu 
    1505                 1510                 1515             


Gln Val  Leu Lys Gly Phe Gly  Cys Phe Leu Tyr Asp  Thr Pro Asp 
    1520                 1525                 1530             


Met Val  Arg Ser Arg His Leu  Arg Lys Leu Trp Ser  Asn Tyr Leu 
    1535                 1540                 1545             


Tyr Thr  Asp Lys Ala Arg Lys  Met Arg Asp Lys Tyr  Lys Val Val 
    1550                 1555                 1560             


Leu Asp  Thr Pro Glu Tyr Arg  Lys Val Gln Glu Leu  Lys Thr His 
    1565                 1570                 1575             


Leu Ser  Glu Leu Val Tyr Arg  Ala Ala Gly Lys Lys  Gln Lys Ser 
    1580                 1585                 1590             


Ile Phe  Thr Ser Val Pro Asp  Thr Pro Asp Leu Leu  Arg Ala Lys 
    1595                 1600                 1605             


Arg Gly  Gln Lys Leu Gln Ser  Gln Tyr Leu Tyr Val  Glu Leu Ala 
    1610                 1615                 1620             


Thr Lys  Glu Arg Pro His His  His Ala Gly Asn Gln  Thr Thr Ala 
    1625                 1630                 1635             


Leu Lys  His Ala Lys Asp Val  Lys Asp Met Val Ser  Glu Lys Lys 
    1640                 1645                 1650             


Tyr Lys  Ile Gln Tyr Glu Lys  Met Lys Asp Lys Tyr  Thr Pro Val 
    1655                 1660                 1665             


Pro Asp  Thr Pro Ile Leu Ile  Arg Ala Lys Arg Ala  Tyr Trp Asn 
    1670                 1675                 1680             


Ala Ser  Asp Leu Arg Tyr Lys  Glu Thr Phe Gln Lys  Thr Lys Gly 
    1685                 1690                 1695             


Lys Tyr  His Thr Val Lys Asp  Ala Leu Asp Ile Val  Tyr His Arg 
    1700                 1705                 1710             


Lys Val  Thr Asp Asp Ile Ser  Lys Ile Lys Tyr Lys  Glu Asn Tyr 
    1715                 1720                 1725             


Met Ser  Gln Leu Gly Ile Trp  Arg Ser Ile Pro Asp  Arg Pro Glu 
    1730                 1735                 1740             


His Phe  His His Arg Ala Val  Thr Asp Thr Val Ser  Asp Val Lys 
    1745                 1750                 1755             


Tyr Lys  Glu Asp Leu Thr Trp  Leu Lys Gly Ile Gly  Cys Tyr Ala 
    1760                 1765                 1770             


Tyr Asp  Thr Pro Asp Phe Thr  Leu Ala Glu Lys Asn  Lys Thr Leu 
    1775                 1780                 1785             


Tyr Ser  Lys Tyr Lys Tyr Lys  Glu Val Phe Glu Arg  Thr Lys Ser 
    1790                 1795                 1800             


Asp Phe  Lys Tyr Val Ala Asp  Ser Pro Ile Asn Arg  His Phe Lys 
    1805                 1810                 1815             


Tyr Ala  Thr Gln Leu Met Asn  Glu Lys Lys Tyr Arg  Ala Asp Tyr 
    1820                 1825                 1830             


Glu Gln  Arg Lys Asp Lys Tyr  His Leu Val Val Asp  Glu Pro Arg 
    1835                 1840                 1845             


His Leu  Leu Ala Lys Thr Ala  Gly Asp Gln Ile Ser  Gln Ile Lys 
    1850                 1855                 1860             


Tyr Arg  Lys Asn Tyr Glu Lys  Ser Lys Asp Lys Phe  Thr Ser Ile 
    1865                 1870                 1875             


Val Asp  Thr Pro Glu His Leu  Arg Thr Thr Lys Val  Asn Lys Gln 
    1880                 1885                 1890             


Ile Ser  Asp Ile Leu Tyr Lys  Leu Glu Tyr Asn Lys  Ala Lys Pro 
    1895                 1900                 1905             


Arg Gly  Tyr Thr Thr Ile His  Asp Thr Pro Met Leu  Leu His Val 
    1910                 1915                 1920             


Arg Lys  Val Lys Asp Glu Val  Ser Asp Leu Lys Tyr  Lys Glu Val 
    1925                 1930                 1935             


Tyr Gln  Arg Asn Lys Ser Asn  Cys Thr Ile Glu Pro  Asp Ala Val 
    1940                 1945                 1950             


His Ile  Lys Ala Ala Lys Asp  Ala Tyr Lys Val Asn  Thr Asn Leu 
    1955                 1960                 1965             


Asp Tyr  Lys Lys Gln Tyr Glu  Ala Asn Lys Ala His  Trp Lys Trp 
    1970                 1975                 1980             


Thr Pro  Asp Arg Pro Asp Phe  Leu Gln Ala Ala Lys  Ser Ser Leu 
    1985                 1990                 1995             


Gln Gln  Ser Asp Phe Glu Tyr  Lys Leu Asp Arg Glu  Phe Leu Lys 
    2000                 2005                 2010             


Gly Cys  Lys Leu Ser Val Thr  Asp Asp Lys Asn Thr  Val Leu Ala 
    2015                 2020                 2025             


Leu Arg  Asn Thr Leu Ile Glu  Ser Asp Leu Lys Tyr  Lys Glu Lys 
    2030                 2035                 2040             


His Val  Lys Glu Arg Gly Thr  Cys His Ala Val Pro  Asp Thr Pro 
    2045                 2050                 2055             


Gln Ile  Leu Leu Ala Lys Thr  Val Ser Asn Leu Val  Ser Glu Asn 
    2060                 2065                 2070             


Lys Tyr  Lys Asp His Val Lys  Lys His Leu Ala Gln  Gly Ser Tyr 
    2075                 2080                 2085             


Thr Thr  Leu Pro Glu Thr Arg  Asp Thr Val His Val  Lys Glu Val 
    2090                 2095                 2100             


Thr Lys  His Val Ser Asp Thr  Asn Tyr Lys Lys Lys  Phe Val Lys 
    2105                 2110                 2115             


Glu Lys  Gly Lys Ser Asn Tyr  Ser Ile Met Leu Glu  Pro Pro Glu 
    2120                 2125                 2130             


Val Lys  His Ala Met Glu Val  Ala Lys Lys Gln Ser  Asp Val Ala 
    2135                 2140                 2145             


Tyr Arg  Lys Asp Ala Lys Glu  Asn Leu His Tyr Thr  Thr Val Ala 
    2150                 2155                 2160             


Asp Arg  Pro Asp Ile Lys Lys  Ala Thr Gln Ala Ala  Lys Gln Ala 
    2165                 2170                 2175             


Ser Glu  Val Glu Tyr Arg Ala  Lys His Arg Lys Glu  Gly Ser His 
    2180                 2185                 2190             


Gly Leu  Ser Met Leu Gly Arg  Pro Asp Ile Glu Met  Ala Lys Lys 
    2195                 2200                 2205             


Ala Ala  Lys Leu Ser Ser Gln  Val Lys Tyr Arg Glu  Asn Phe Asp 
    2210                 2215                 2220             


Lys Glu  Lys Gly Lys Thr Pro  Lys Tyr Asn Pro Lys  Asp Ser Gln 
    2225                 2230                 2235             


Leu Tyr  Lys Val Met Lys Asp  Ala Asn Asn Leu Ala  Ser Glu Val 
    2240                 2245                 2250             


Lys Tyr  Lys Ala Asp Leu Lys  Lys Leu His Lys Pro  Val Thr Asp 
    2255                 2260                 2265             


Met Lys  Glu Ser Leu Ile Met  Asn His Val Leu Asn  Thr Ser Gln 
    2270                 2275                 2280             


Leu Ala  Ser Ser Tyr Gln Tyr  Lys Lys Lys Tyr Glu  Lys Ser Lys 
    2285                 2290                 2295             


Gly His  Tyr His Thr Ile Pro  Asp Asn Leu Glu Gln  Leu His Leu 
    2300                 2305                 2310             


Lys Glu  Ala Thr Glu Leu Gln  Ser Ile Val Lys Tyr  Lys Glu Lys 
    2315                 2320                 2325             


Tyr Glu  Lys Glu Arg Gly Lys  Pro Met Leu Asp Phe  Glu Thr Pro 
    2330                 2335                 2340             


Thr Tyr  Ile Thr Ala Lys Glu  Ser Gln Gln Met Gln  Ser Gly Lys 
    2345                 2350                 2355             


Glu Tyr  Arg Lys Asp Tyr Glu  Glu Ser Ile Lys Gly  Arg Asn Leu 
    2360                 2365                 2370             


Thr Gly  Leu Glu Val Thr Pro  Ala Leu Leu His Val  Lys Tyr Ala 
    2375                 2380                 2385             


Thr Lys  Ile Ala Ser Glu Lys  Glu Tyr Arg Lys Asp  Leu Glu Glu 
    2390                 2395                 2400             


Ser Ile  Arg Gly Lys Gly Leu  Thr Glu Met Glu Asp  Thr Pro Asp 
    2405                 2410                 2415             


Met Leu  Arg Ala Lys Asn Ala  Thr Gln Ile Leu Asn  Glu Lys Glu 
    2420                 2425                 2430             


Tyr Lys  Arg Asp Leu Glu Leu  Glu Val Lys Gly Arg  Gly Leu Asn 
    2435                 2440                 2445             


Ala Met  Ala Asn Glu Thr Pro  Asp Phe Met Arg Ala  Arg Asn Ala 
    2450                 2455                 2460             


Thr Asp  Ile Ala Ser Gln Ile  Lys Tyr Lys Gln Ser  Ala Glu Met 
    2465                 2470                 2475             


Glu Lys  Ala Asn Phe Thr Ser  Val Val Asp Thr Pro  Glu Ile Ile 
    2480                 2485                 2490             


His Ala  Gln Gln Val Lys Asn  Leu Ser Ser Gln Lys  Lys Tyr Lys 
    2495                 2500                 2505             


Glu Asp  Ala Glu Lys Ser Met  Ser Tyr Tyr Glu Thr  Val Leu Asp 
    2510                 2515                 2520             


Thr Pro  Glu Ile Gln Arg Val  Arg Glu Asn Gln Lys  Asn Phe Ser 
    2525                 2530                 2535             


Leu Leu  Gln Tyr Gln Cys Asp  Leu Lys Asn Ser Lys  Gly Lys Ile 
    2540                 2545                 2550             


Thr Val  Val Gln Asp Thr Pro  Glu Ile Leu Arg Val  Lys Glu Asn 
    2555                 2560                 2565             


Gln Lys  Asn Phe Ser Ser Val  Leu Tyr Lys Glu Asp  Val Ser Pro 
    2570                 2575                 2580             


Gly Thr  Ala Ile Gly Lys Thr  Pro Glu Met Met Arg  Val Lys Gln 
    2585                 2590                 2595             


Thr Gln  Asp His Ile Ser Ser  Val Lys Tyr Lys Glu  Ala Ile Gly 
    2600                 2605                 2610             


Gln Gly  Thr Pro Ile Pro Asp  Leu Pro Glu Val Lys  Arg Val Lys 
    2615                 2620                 2625             


Glu Thr  Gln Lys His Ile Ser  Ser Val Met Tyr Lys  Glu Asn Leu 
    2630                 2635                 2640             


Gly Thr  Gly Ile Pro Thr Thr  Val Thr Pro Glu Ile  Glu Arg Val 
    2645                 2650                 2655             


Lys Arg  Asn Gln Glu Asn Phe  Ser Ser Val Leu Tyr  Lys Glu Asn 
    2660                 2665                 2670             


Met Gly  Lys Gly Thr Pro Leu  Ala Val Thr Pro Glu  Met Glu Arg 
    2675                 2680                 2685             


Val Lys  His Asn Gln Glu Asn  Ile Ser Ser Val Leu  Tyr Lys Glu 
    2690                 2695                 2700             


Asn Val  Gly Lys Ala Thr Ala  Thr Pro Val Thr Pro  Glu Met Gln 
    2705                 2710                 2715             


Arg Val  Lys Arg Asn Gln Glu  Asn Ile Ser Ser Val  Leu Tyr Ser 
    2720                 2725                 2730             


Asp Ser  Phe Arg Lys Gln Ile  Gln Gly Lys Ala Ala  Tyr Val Leu 
    2735                 2740                 2745             


Asp Thr  Pro Glu Met Arg Arg  Val Arg Glu Thr Gln  Arg His Ile 
    2750                 2755                 2760             


Ser Thr  Val Lys Tyr His Glu  Asp Phe Glu Lys His  Lys Gly Cys 
    2765                 2770                 2775             


Phe Thr  Pro Val Val Thr Asp  Pro Ile Thr Glu Arg  Val Lys Lys 
    2780                 2785                 2790             


Asn Met  Gln Asp Phe Ser Asp  Ile Asn Tyr Arg Gly  Ile Gln Arg 
    2795                 2800                 2805             


Lys Val  Val Glu Met Glu Gln  Lys Arg Asn Asp Gln  Asp Gln Glu 
    2810                 2815                 2820             


Thr Ile  Thr Gly Leu Arg Val  Trp Arg Thr Asn Pro  Gly Ser Val 
    2825                 2830                 2835             


Phe Asp  Tyr Asp Pro Ala Glu  Asp Asn Ile Gln Ser  Arg Ser Leu 
    2840                 2845                 2850             


His Met  Ile Asn Val Gln Ala  Gln Arg Arg Ser Arg  Glu Gln Ser 
    2855                 2860                 2865             


Arg Ser  Ala Ser Ala Leu Ser  Ile Ser Gly Gly Glu  Glu Lys Ser 
    2870                 2875                 2880             


Glu His  Ser Glu Ala Pro Asp  His His Leu Ser Thr  Tyr Ser Asp 
    2885                 2890                 2895             


Gly Gly  Val Phe Ala Val Ser  Thr Ala Tyr Lys His  Ala Lys Thr 
    2900                 2905                 2910             


Thr Glu  Leu Pro Gln Gln Arg  Ser Ser Ser Val Ala  Thr Gln Gln 
    2915                 2920                 2925             


Thr Thr  Val Ser Ser Ile Pro  Ser His Pro Ser Thr  Ala Gly Lys 
    2930                 2935                 2940             


Ile Phe  Arg Ala Met Tyr Asp  Tyr Met Ala Ala Asp  Ala Asp Glu 
    2945                 2950                 2955             


Val Ser  Phe Lys Asp Gly Asp  Ala Ile Ile Asn Val  Gln Ala Ile 
    2960                 2965                 2970             


Asp Glu  Gly Trp Met Tyr Gly  Thr Val Gln Arg Thr  Gly Arg Thr 
    2975                 2980                 2985             


Gly Met  Leu Pro Ala Asn Tyr  Val Glu Ala Ile 
    2990                 2995                 


<210>  8481
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  8481
aggcatcacg ctggcttttg cctggggttc tcaggagggg agagttggga gaggctttgc     60

tgctgaggaa atttatttgg tagattgaag gtttgaacga gagctacaga aacgaaagaa    120

aaagtctgta taagccaatg gtgttcggga agaaaataac cccattgcct tgagtttgta    180

ggtgccacta ctactctgga aaaatggcag atgacgaaga ctatgaggag gtggtggagt    240

actacacaga agaagtggtt tacgaagagg tgccgggaga gacaataaca aaaatttatg    300

agactacgac aacaaggaca tctgactatg agcaatcaga aacttccaaa ccagctctgg    360

cacagccagc actggcacag ccagcatcag caaagccggt ggagaggagg aaggtcatcc    420

ggaagaaagt ggatccttca aagttcatga ccccctacat tgcacacagt cagaaaatgc    480

aggatctttt tagcccaaat aaatacaagg agaagtttga gaaaacaaaa ggacagccat    540

acgccagcac aacagatact ccagaacttc gcagaatcaa aaaagtacaa gatcaactca    600

gtgaggttaa gtatcgaatg gatggtgatg ttgctaagac tatatgtcac gtagatgaaa    660

aagcaaagga tattgaacat gcaaagaaag tgtcgcagca agtcagtaag gttttataca    720

agcagaactg ggaagacacc aaggataagt acctgcttcc tcctgatgcc cctgaacttg    780

tccaggccgt taagaacacc gccatgttca gcaagaaact gtacactgaa gactgggaag    840

cagacaaaag tttgttttac ccctataatg atagcccgga actgaggaga gttgcccagg    900

cccagaaagc tctcagtgat gttgcctaca aaaaaggtct cgctgaacag caagctcaat    960

tcacgcctct ggctgatcct ccagatatag aatttgccaa gaaagtaacc aatcaagtga   1020

gcaagcaaaa atacaaagaa gactatgaaa ataaaatcaa aggcaaatgg agtgagacac   1080

cttgctttga agttgcaaat gccagaatga atgctgataa cattagcaca aggaaatacc   1140

aggaagattt tgaaaacatg aaagaccaga tctacttcat gcagaccgaa acaccagagt   1200

ataaaatgaa taaaaaagct ggtgtggcag ctagcaaggt aaaatacaaa gaagactatg   1260

aaaagaataa aggaaaagca gattataatg tgcttcctgc ttcagagaac ccacagctta   1320

ggcagctgaa ggcagcagga gatgccctaa gtgacaaact atacaaggaa aactatgaaa   1380

agacaaaagc aaagagcata aattactgcg agacccccaa attcaagctc gatactgttc   1440

tgcagaactt cagtagtgat aaaaaatata aagattccta cttaaaagat attttgggac   1500

attatgtagg cagcttcgag gatccatacc attcacactg catgaaagtc acagctcaaa   1560

acagtgataa aaactacaaa gcagaatacg aagaagacag aggcaaaggc ttcttccctc   1620

agaccataac tcaagaatat gaagcaatta agaaactaga tcagtgtaaa gaccacacct   1680

acaaagtcca tccagataag acaaaattca cccaagttac agactctcct gttctgctac   1740

aagcccaagt caattccaaa caactgagtg acttaaatta caaagcaaaa catgaaagtg   1800

aaaagttcaa gtgccatatc ccccctgata ctcctgcttt tatccagcac aaagtcaatg   1860

cctataactt gagtgataat ctttataagc aagactggga gaagagcaaa gccaaaaagt   1920

ttgacattaa agtggatgcc attcccctgc tggcagccaa agccaacacc aagaacacca   1980

gcgatgtgat gtacaagaaa gactatgaaa aaaacaaagg gaaaatgatt ggagtcctca   2040

gcattaatga cgatcccaag atgctgcact ccttgaaggt ggccaaaaac cagagtgata   2100

gattatacaa ggaaaactat gagaagacaa aggcaaagag tatgaattac tgtgagaccc   2160

caaaatatca acttgatact cagctgaaga acttcagtga ggctagatat aaagacttat   2220

atgtaaagga tgttttggga cattatgtag gcagcatgga ggacccatat cacacacact   2280

gcatgaaagt tgcagctcaa aacagtgata aaagttacaa agcagaatat gaagaagata   2340

aaggaaaatg ctatttccct cagacaataa cacaagaata tgaagcaatc aagaagctgg   2400

accagtgtaa agatcatacc tacaaagttc atccagataa gaccaaattc acggcagtca   2460

ctgattctcc tgtactgttg caagcccagc tcaacacgaa acagcttagt gatctgaatt   2520

acaaagcaaa acatgaaggt gagaagttca agtgccatat accagcagat gctccacagt   2580

ttatccaaca cagagtcaat gcctataatc tgagtgataa tgtttataag caagactggg   2640

agaagagcaa agccaagaag tttgacatta aagtggacgc cattcccctg ttggcagcca   2700

aagccaacac caagaacacc agcgatgtga tgtacaagaa agactatgaa aagagcaaag   2760

ggaaaatgat tggagccctc agcattaatg acgatccaaa gatgctgcac tccttgaaga   2820

cagccaaaaa ccagagtgat cgcgaatatc gaaaagatta tgaaaagtca aaaactatct   2880

acacggcacc tcttgatatg ctccaagtca ctcaagctaa gaaatctcag gcaattgcca   2940

gcgacgttga ttataagcac atcttacaca gttacagcta cccccctgat agcatcaatg   3000

tggaccttgc caagaaggca tatgcgctgc agagcgatgt tgaatacaaa gctgactaca   3060

atagctggat gaaaggttgt ggctgggtgc cttttgggtc cttagaaatg gaaaaggcaa   3120

agcgagcttc agacatcctc aatgagaaaa aatatcgcca acatccagac accctcaagt   3180

ttacctcgat tgaagatgct ccaattacag tacagtctaa aattaaccag gcccagagga   3240

gtgatatcgc ttacaaagcc aaaggagagg aaattattca caaatacaac ctgccaccag   3300

acctgcccca gttcatccag gctaaagtta atgcctacaa tatcagtgag aatatgtaca   3360

aagcagactt gaaagacttg agcaagaagg gatatgacct gagaactgat gcgattccca   3420

tcagagctgc caaagctgcc aggcaggcgg cgagtgacgt tcagtacaaa aaagactatg   3480

aaaaggctaa agggaaaatg gttggcttcc aaagtcttca agatgaccct aaactggttc   3540

attatatgaa cgtggccaag atacaatcag atcgggagta taaaaaagac tatgagaaga   3600

caaagtccaa atacaacacg ccccatgata tgttcaatgt cgtggcggct aagaaagccc   3660

aggatgtggt cagcaatgtc aactataagc attctctcca tcattacacc tacttgcctg   3720

acgccatgga cctggagctg tctaagaaca tgatgcagat acagagtgat aacgtctaca   3780

aggaagacta caacaactgg atgaaaggca ttggctggat tcctattggc agtctcgacg   3840

tcgaaaaagt taaaaaggcc ggtgatgctc tgaatgaaaa gaagtacagg caacatccag   3900

acaccctcaa atttaccagc attgtggact ccccagttat ggtccaggca aaacagaaca   3960

cgaagcaagt cagtgatatc ttatacaagg ctaaaggaga agatgtgaaa cataaataca   4020

ccatgagtcc tgatcttcct cagtttctcc aggccaagtg caatgcttac aatataagtg   4080

acgtctgtta taaacgggat tggtatgact taatagccaa gggcaacaat gtgctgggcg   4140

atgctattcc catcactgca gccaaggcat cgagaaacat tgccagtgat tataaataca   4200

aggaagctta tgagaagtca aagggaaagc atgtgggttt cagaagcctc caggatgatc   4260

ccaagctggt ccactatatg aatgtggcaa agctgcagtc tgatcgtgaa tacaagaaga   4320

actatgagaa caccaaaacc agctaccata cccctgggga catggttagc atcacagctg   4380

caaagatggc ccaggatgtc gctaccaatg tcaactacaa acagccattg catcattaca   4440

catacctacc tgacgccatg agtcttgagc atacgaggaa tgtcaatcaa attcagagtg   4500

ataatgtgta taaagacgag tataacagct tcttgaaggg catcggatgg atccctattg   4560

gttccctgga ggtggagaag gtcaagaaag caggcgatgc attaaatgag aggaagtatc   4620

gacagcaccc agataccgtc aagttcacaa gtgtgcctga ttccatgggc atggtgttgg   4680

ctcagcataa cacaaagcag ctaagtgatt tgaactacaa ggtagaggga gagaaactga   4740

agcacaagta tactattgac cctgaattgc ctcagtttat tcaagccaaa gtcaacgccc   4800

tcaacatgag tgatgctcat tataaagcag attggaagaa aaccattgcc aagggctatg   4860

atttgagacc agatgccatc ccaattgttg ctgcaaaaag ttcaaggaat attgctagtg   4920

attgcaaata taaggaggcc tacgagaaag ccaaaggcaa gcaagttgga tttctcagtc   4980

ttcaggatga tcctaaactg gttcactaca tgaatgtggc caaaatccag tctgatcgtg   5040

agtacaaaaa gggctatgaa gccagcaaga ccaagtacca cacacctctg gatatggtca   5100

gtgtgacagc tgcaaagaaa tctcaggagg ttgccaccaa cgccaactac agacagtcat   5160

accaccacta cactctcctg cccgatgcct tgaatgtgga gcactccagg aatgccatgc   5220

agattcagag tgataatctg tacaaatctg acttcaccaa ttggatgaaa gggatcggct   5280

gggtgcccat agagtccctg gaggtggaga aggcaaagaa agcaggagag attcttagtg   5340

agaagaagta tcgccagcac cccgagaagc tgaagttcac ttacgccatg gacacaatgg   5400

aacaggcact taacaagagt aacaaactga acatggacaa gaggctctac actgaaaaat   5460

ggaacaagga caagaccacc attcatgtca tgcctgacac accggatatt ttactctcca   5520

gagtaaacca aatcaccatg agtgataaac tgtacaaagc tggctgggaa gaggaaaaga   5580

agaaaggata tgacctgagg cctgatgcca ttgcaataaa ggctgcaaga gcctctagag   5640

acattgccag tgattacaaa tacaagaaag cctatgaaca agccaaaggg aaacacattg   5700

gcttccggag cctggaagat gaccccaagc tggtgcactt catgcaagtg gccaagatgc   5760

agtcagaccg ggaatacaag aagggatatg agaaatccaa gacctccttc cacaccccgg   5820

tggacatgct cagtgtggtg gcagccaaga agtctcagga agtggccacc aatgccaact   5880

acaggaacgt gatccatacc tacaacatgc ttcctgatgc catgagcttt gaattggcca   5940

aaaatatgat gcagattcaa agtgataatc agtacaaggc tgactatgct gacttcatga   6000

agggcattgg atggctccct ctgggctccc tggaagcaga gaaaaacaag aaagccatgg   6060

agattattag tgaaaagaag taccgccagc acccagacac tttgaagtat tccacactca   6120

tggactcgat gaacatggtt ttggcccaga ataatgcaaa aattatgaac gaacatctct   6180

acaaacaagc atgggaggct gacaaaacca aagtccacat catgcctgat atcccccaga   6240

ttattttggc aaaggcaaat gcaattaata tgagtgataa actctacaaa ctttccttgg   6300

aagagtctaa aaagaaaggc tatgatctca gacctgatgc aattcctatc aaagctgcca   6360

aggcttccag agatattgca agtgattata aatacaagta caattatgaa aaagggaagg   6420

ggaaaatggt tggtttccgc agtctcgagg atgatcccaa attagtccat tccatgcaag   6480

tggctaagat gcaatctgat cgggagtaca agaaaaacta tgagaacaca aagaccagct   6540

accacacccc tgccgacatg ctcagtgtca cggctgcaaa ggatgcccaa gccaacatca   6600

ccaacactaa ctacaagcac ctgattcaca agtacatcct ccttccagat gcaatgaaca   6660

ttgagctgac caggaatatg aatcgcatac agagtgataa tgaatataag caagattaca   6720

atgaatggta caaagggctt ggctggagtc cagcaggttc tctggaagtg gagaaggcca   6780

agaaagcaac tgaatatgcc agtgatcaga aataccgcca gcacccgagc aacttccagt   6840

ttaagaagct gactgattcc atggacatgg tgcttgccaa gcagaatgca cataccatga   6900

acaagcattt atacaccatt gattggaata aagataagac caagattcat gtgatgcctg   6960

atacaccaga tattttacaa gccaagcaga atcaaacact gtatagtcag aaactctata   7020

aacttggatg ggaagaagct ttgaagaaag gctatgatct cccagttgat gcaatttctg   7080

tacagctagc taaagcttca agagacattg ctagtgatta taaatacaaa caaggctacc   7140

gaaagcaact tggccaccat gttggattcc ggagtctgca agatgaccca aaacttgtgt   7200

tgtccatgaa tgtagccaaa atgcagagtg aaagagaata caagaaggac tttgagaagt   7260

ggaaaactaa gttctccagc ccagtggaca tgttgggagt ggtactggcc aagaagtgtc   7320

aggagttggt tagtgacgtg gactacaaga actacctgca tcagtggaca tgtctgcctg   7380

atcagaacga tgttgtgcaa gctaagaaag tttatgaact gcaaagtgag aatctatata   7440

aatctgacct tgagtggctg agaggcatag gatggagtcc cttgggttct ttagaggcag   7500

aaaagaacaa gcgggcttcg gaaatcatca gtgagaagaa atatcgtcag cctccagaca   7560

gaaacaagtt caccagcatt cctgatgcca tggatatagt tctggcaaag acaaatgcca   7620

aaaataggag tgatagactt tatagagaag cttgggacaa agacaagact cagatccaca   7680

tcatgcctga tacacctgac attgttctgg ctaaagcaaa cttaatcaac acaagtgata   7740

aactctaccg aatgggttat gaggagctga agagaaaagg ttacgatctt cctgttgatg   7800

ccataccaat caaagcagca aaagcctccc gggaaattgc cagtgaatac aagtacaagg   7860

aaggctttcg caagcagctc ggccaccaca ttggtgcccg gaacattgaa gatgacccca   7920

agatgatgtg gtccatgcat gtggccaaga tccagagtga cagggagtac aagaaggact   7980

ttgagaagtg gaagaccaag ttcagcagcc cagtggacat gctgggggtg gtgttggcca   8040

agaagtgcca gaccttagtc agcgacgtgg actacaagaa ctacctgcac cagtggacat   8100

gcctgcccga ccagagcgat gtcatccatg ctcggcaggc ctatgacctc cagagcgata   8160

atttgtacaa gtcagacctt cagtggctaa aa                                 8192


<210>  8482
<211>  4000
<212>  PRT
<213>  Homosapiens

<400>  8482

Met Ala Asp Asp Glu Asp Tyr Glu Glu Val Val Glu Tyr Tyr Thr Glu 
1               5                   10                  15      


Glu Val Val Tyr Glu Glu Val Pro Gly Glu Thr Ile Thr Lys Ile Tyr 
            20                  25                  30          


Glu Thr Thr Thr Thr Arg Thr Ser Asp Tyr Glu Gln Ser Glu Thr Ser 
        35                  40                  45              


Lys Pro Ala Leu Ala Gln Pro Ala Leu Ala Gln Pro Ala Ser Ala Lys 
    50                  55                  60                  


Pro Val Glu Arg Arg Lys Val Ile Arg Lys Lys Val Asp Pro Ser Lys 
65                  70                  75                  80  


Phe Met Thr Pro Tyr Ile Ala His Ser Gln Lys Met Gln Asp Leu Phe 
                85                  90                  95      


Ser Pro Asn Lys Tyr Lys Glu Lys Phe Glu Lys Thr Lys Gly Gln Pro 
            100                 105                 110         


Tyr Ala Ser Thr Thr Asp Thr Pro Glu Leu Arg Arg Ile Lys Lys Val 
        115                 120                 125             


Gln Asp Gln Leu Ser Glu Val Lys Tyr Arg Met Asp Gly Asp Val Ala 
    130                 135                 140                 


Lys Thr Ile Cys His Val Asp Glu Lys Ala Lys Asp Ile Glu His Ala 
145                 150                 155                 160 


Lys Lys Val Ser Gln Gln Val Ser Lys Val Leu Tyr Lys Gln Asn Trp 
                165                 170                 175     


Glu Asp Thr Lys Asp Lys Tyr Leu Leu Pro Pro Asp Ala Pro Glu Leu 
            180                 185                 190         


Val Gln Ala Val Lys Asn Thr Ala Met Phe Ser Lys Lys Leu Tyr Thr 
        195                 200                 205             


Glu Asp Trp Glu Ala Asp Lys Ser Leu Phe Tyr Pro Tyr Asn Asp Ser 
    210                 215                 220                 


Pro Glu Leu Arg Arg Val Ala Gln Ala Gln Lys Ala Leu Ser Asp Val 
225                 230                 235                 240 


Ala Tyr Lys Lys Gly Leu Ala Glu Gln Gln Ala Gln Phe Thr Pro Leu 
                245                 250                 255     


Ala Asp Pro Pro Asp Ile Glu Phe Ala Lys Lys Val Thr Asn Gln Val 
            260                 265                 270         


Ser Lys Gln Lys Tyr Lys Glu Asp Tyr Glu Asn Lys Ile Lys Gly Lys 
        275                 280                 285             


Trp Ser Glu Thr Pro Cys Phe Glu Val Ala Asn Ala Arg Met Asn Ala 
    290                 295                 300                 


Asp Asn Ile Ser Thr Arg Lys Tyr Gln Glu Asp Phe Glu Asn Met Lys 
305                 310                 315                 320 


Asp Gln Ile Tyr Phe Met Gln Thr Glu Thr Pro Glu Tyr Lys Met Asn 
                325                 330                 335     


Lys Lys Ala Gly Val Ala Ala Ser Lys Val Lys Tyr Lys Glu Asp Tyr 
            340                 345                 350         


Glu Lys Asn Lys Gly Lys Ala Asp Tyr Asn Val Leu Pro Ala Ser Glu 
        355                 360                 365             


Asn Pro Gln Leu Arg Gln Leu Lys Ala Ala Gly Asp Ala Leu Ser Asp 
    370                 375                 380                 


Lys Leu Tyr Lys Glu Asn Tyr Glu Lys Thr Lys Ala Lys Ser Ile Asn 
385                 390                 395                 400 


Tyr Cys Glu Thr Pro Lys Phe Lys Leu Asp Thr Val Leu Gln Asn Phe 
                405                 410                 415     


Ser Ser Asp Lys Lys Tyr Lys Asp Ser Tyr Leu Lys Asp Ile Leu Gly 
            420                 425                 430         


His Tyr Val Gly Ser Phe Glu Asp Pro Tyr His Ser His Cys Met Lys 
        435                 440                 445             


Val Thr Ala Gln Asn Ser Asp Lys Asn Tyr Lys Ala Glu Tyr Glu Glu 
    450                 455                 460                 


Asp Arg Gly Lys Gly Phe Phe Pro Gln Thr Ile Thr Gln Glu Tyr Glu 
465                 470                 475                 480 


Ala Ile Lys Lys Leu Asp Gln Cys Lys Asp His Thr Tyr Lys Val His 
                485                 490                 495     


Pro Asp Lys Thr Lys Phe Thr Gln Val Thr Asp Ser Pro Val Leu Leu 
            500                 505                 510         


Gln Ala Gln Val Asn Ser Lys Gln Leu Ser Asp Leu Asn Tyr Lys Ala 
        515                 520                 525             


Lys His Glu Ser Glu Lys Phe Lys Cys His Ile Pro Pro Asp Thr Pro 
    530                 535                 540                 


Ala Phe Ile Gln His Lys Val Asn Ala Tyr Asn Leu Ser Asp Asn Leu 
545                 550                 555                 560 


Tyr Lys Gln Asp Trp Glu Lys Ser Lys Ala Lys Lys Phe Asp Ile Lys 
                565                 570                 575     


Val Asp Ala Ile Pro Leu Leu Ala Ala Lys Ala Asn Thr Lys Asn Thr 
            580                 585                 590         


Ser Asp Val Met Tyr Lys Lys Asp Tyr Glu Lys Asn Lys Gly Lys Met 
        595                 600                 605             


Ile Gly Val Leu Ser Ile Asn Asp Asp Pro Lys Met Leu His Ser Leu 
    610                 615                 620                 


Lys Val Ala Lys Asn Gln Ser Asp Arg Leu Tyr Lys Glu Asn Tyr Glu 
625                 630                 635                 640 


Lys Thr Lys Ala Lys Ser Met Asn Tyr Cys Glu Thr Pro Lys Tyr Gln 
                645                 650                 655     


Leu Asp Thr Gln Leu Lys Asn Phe Ser Glu Ala Arg Tyr Lys Asp Leu 
            660                 665                 670         


Tyr Val Lys Asp Val Leu Gly His Tyr Val Gly Ser Met Glu Asp Pro 
        675                 680                 685             


Tyr His Thr His Cys Met Lys Val Ala Ala Gln Asn Ser Asp Lys Ser 
    690                 695                 700                 


Tyr Lys Ala Glu Tyr Glu Glu Asp Lys Gly Lys Cys Tyr Phe Pro Gln 
705                 710                 715                 720 


Thr Ile Thr Gln Glu Tyr Glu Ala Ile Lys Lys Leu Asp Gln Cys Lys 
                725                 730                 735     


Asp His Thr Tyr Lys Val His Pro Asp Lys Thr Lys Phe Thr Ala Val 
            740                 745                 750         


Thr Asp Ser Pro Val Leu Leu Gln Ala Gln Leu Asn Thr Lys Gln Leu 
        755                 760                 765             


Ser Asp Leu Asn Tyr Lys Ala Lys His Glu Gly Glu Lys Phe Lys Cys 
    770                 775                 780                 


His Ile Pro Ala Asp Ala Pro Gln Phe Ile Gln His Arg Val Asn Ala 
785                 790                 795                 800 


Tyr Asn Leu Ser Asp Asn Val Tyr Lys Gln Asp Trp Glu Lys Ser Lys 
                805                 810                 815     


Ala Lys Lys Phe Asp Ile Lys Val Asp Ala Ile Pro Leu Leu Ala Ala 
            820                 825                 830         


Lys Ala Asn Thr Lys Asn Thr Ser Asp Val Met Tyr Lys Lys Asp Tyr 
        835                 840                 845             


Glu Lys Ser Lys Gly Lys Met Ile Gly Ala Leu Ser Ile Asn Asp Asp 
    850                 855                 860                 


Pro Lys Met Leu His Ser Leu Lys Thr Ala Lys Asn Gln Ser Asp Arg 
865                 870                 875                 880 


Glu Tyr Arg Lys Asp Tyr Glu Lys Ser Lys Thr Ile Tyr Thr Ala Pro 
                885                 890                 895     


Leu Asp Met Leu Gln Val Thr Gln Ala Lys Lys Ser Gln Ala Ile Ala 
            900                 905                 910         


Ser Asp Val Asp Tyr Lys His Ile Leu His Ser Tyr Ser Tyr Pro Pro 
        915                 920                 925             


Asp Ser Ile Asn Val Asp Leu Ala Lys Lys Ala Tyr Ala Leu Gln Ser 
    930                 935                 940                 


Asp Val Glu Tyr Lys Ala Asp Tyr Asn Ser Trp Met Lys Gly Cys Gly 
945                 950                 955                 960 


Trp Val Pro Phe Gly Ser Leu Glu Met Glu Lys Ala Lys Arg Ala Ser 
                965                 970                 975     


Asp Ile Leu Asn Glu Lys Lys Tyr Arg Gln His Pro Asp Thr Leu Lys 
            980                 985                 990         


Phe Thr Ser Ile Glu Asp Ala Pro  Ile Thr Val Gln Ser  Lys Ile Asn 
        995                 1000                 1005             


Gln Ala  Gln Arg Ser Asp Ile  Ala Tyr Lys Ala Lys  Gly Glu Glu 
    1010                 1015                 1020             


Ile Ile  His Lys Tyr Asn Leu  Pro Pro Asp Leu Pro  Gln Phe Ile 
    1025                 1030                 1035             


Gln Ala  Lys Val Asn Ala Tyr  Asn Ile Ser Glu Asn  Met Tyr Lys 
    1040                 1045                 1050             


Ala Asp  Leu Lys Asp Leu Ser  Lys Lys Gly Tyr Asp  Leu Arg Thr 
    1055                 1060                 1065             


Asp Ala  Ile Pro Ile Arg Ala  Ala Lys Ala Ala Arg  Gln Ala Ala 
    1070                 1075                 1080             


Ser Asp  Val Gln Tyr Lys Lys  Asp Tyr Glu Lys Ala  Lys Gly Lys 
    1085                 1090                 1095             


Met Val  Gly Phe Gln Ser Leu  Gln Asp Asp Pro Lys  Leu Val His 
    1100                 1105                 1110             


Tyr Met  Asn Val Ala Lys Ile  Gln Ser Asp Arg Glu  Tyr Lys Lys 
    1115                 1120                 1125             


Asp Tyr  Glu Lys Thr Lys Ser  Lys Tyr Asn Thr Pro  His Asp Met 
    1130                 1135                 1140             


Phe Asn  Val Val Ala Ala Lys  Lys Ala Gln Asp Val  Val Ser Asn 
    1145                 1150                 1155             


Val Asn  Tyr Lys His Ser Leu  His His Tyr Thr Tyr  Leu Pro Asp 
    1160                 1165                 1170             


Ala Met  Asp Leu Glu Leu Ser  Lys Asn Met Met Gln  Ile Gln Ser 
    1175                 1180                 1185             


Asp Asn  Val Tyr Lys Glu Asp  Tyr Asn Asn Trp Met  Lys Gly Ile 
    1190                 1195                 1200             


Gly Trp  Ile Pro Ile Gly Ser  Leu Asp Val Glu Lys  Val Lys Lys 
    1205                 1210                 1215             


Ala Gly  Asp Ala Leu Asn Glu  Lys Lys Tyr Arg Gln  His Pro Asp 
    1220                 1225                 1230             


Thr Leu  Lys Phe Thr Ser Ile  Val Asp Ser Pro Val  Met Val Gln 
    1235                 1240                 1245             


Ala Lys  Gln Asn Thr Lys Gln  Val Ser Asp Ile Leu  Tyr Lys Ala 
    1250                 1255                 1260             


Lys Gly  Glu Asp Val Lys His  Lys Tyr Thr Met Ser  Pro Asp Leu 
    1265                 1270                 1275             


Pro Gln  Phe Leu Gln Ala Lys  Cys Asn Ala Tyr Asn  Ile Ser Asp 
    1280                 1285                 1290             


Val Cys  Tyr Lys Arg Asp Trp  Tyr Asp Leu Ile Ala  Lys Gly Asn 
    1295                 1300                 1305             


Asn Val  Leu Gly Asp Ala Ile  Pro Ile Thr Ala Ala  Lys Ala Ser 
    1310                 1315                 1320             


Arg Asn  Ile Ala Ser Asp Tyr  Lys Tyr Lys Glu Ala  Tyr Glu Lys 
    1325                 1330                 1335             


Ser Lys  Gly Lys His Val Gly  Phe Arg Ser Leu Gln  Asp Asp Pro 
    1340                 1345                 1350             


Lys Leu  Val His Tyr Met Asn  Val Ala Lys Leu Gln  Ser Asp Arg 
    1355                 1360                 1365             


Glu Tyr  Lys Lys Asn Tyr Glu  Asn Thr Lys Thr Ser  Tyr His Thr 
    1370                 1375                 1380             


Pro Gly  Asp Met Val Ser Ile  Thr Ala Ala Lys Met  Ala Gln Asp 
    1385                 1390                 1395             


Val Ala  Thr Asn Val Asn Tyr  Lys Gln Pro Leu His  His Tyr Thr 
    1400                 1405                 1410             


Tyr Leu  Pro Asp Ala Met Ser  Leu Glu His Thr Arg  Asn Val Asn 
    1415                 1420                 1425             


Gln Ile  Gln Ser Asp Asn Val  Tyr Lys Asp Glu Tyr  Asn Ser Phe 
    1430                 1435                 1440             


Leu Lys  Gly Ile Gly Trp Ile  Pro Ile Gly Ser Leu  Glu Val Glu 
    1445                 1450                 1455             


Lys Val  Lys Lys Ala Gly Asp  Ala Leu Asn Glu Arg  Lys Tyr Arg 
    1460                 1465                 1470             


Gln His  Pro Asp Thr Val Lys  Phe Thr Ser Val Pro  Asp Ser Met 
    1475                 1480                 1485             


Gly Met  Val Leu Ala Gln His  Asn Thr Lys Gln Leu  Ser Asp Leu 
    1490                 1495                 1500             


Asn Tyr  Lys Val Glu Gly Glu  Lys Leu Lys His Lys  Tyr Thr Ile 
    1505                 1510                 1515             


Asp Pro  Glu Leu Pro Gln Phe  Ile Gln Ala Lys Val  Asn Ala Leu 
    1520                 1525                 1530             


Asn Met  Ser Asp Ala His Tyr  Lys Ala Asp Trp Lys  Lys Thr Ile 
    1535                 1540                 1545             


Ala Lys  Gly Tyr Asp Leu Arg  Pro Asp Ala Ile Pro  Ile Val Ala 
    1550                 1555                 1560             


Ala Lys  Ser Ser Arg Asn Ile  Ala Ser Asp Cys Lys  Tyr Lys Glu 
    1565                 1570                 1575             


Ala Tyr  Glu Lys Ala Lys Gly  Lys Gln Val Gly Phe  Leu Ser Leu 
    1580                 1585                 1590             


Gln Asp  Asp Pro Lys Leu Val  His Tyr Met Asn Val  Ala Lys Ile 
    1595                 1600                 1605             


Gln Ser  Asp Arg Glu Tyr Lys  Lys Gly Tyr Glu Ala  Ser Lys Thr 
    1610                 1615                 1620             


Lys Tyr  His Thr Pro Leu Asp  Met Val Ser Val Thr  Ala Ala Lys 
    1625                 1630                 1635             


Lys Ser  Gln Glu Val Ala Thr  Asn Ala Asn Tyr Arg  Gln Ser Tyr 
    1640                 1645                 1650             


His His  Tyr Thr Leu Leu Pro  Asp Ala Leu Asn Val  Glu His Ser 
    1655                 1660                 1665             


Arg Asn  Ala Met Gln Ile Gln  Ser Asp Asn Leu Tyr  Lys Ser Asp 
    1670                 1675                 1680             


Phe Thr  Asn Trp Met Lys Gly  Ile Gly Trp Val Pro  Ile Glu Ser 
    1685                 1690                 1695             


Leu Glu  Val Glu Lys Ala Lys  Lys Ala Gly Glu Ile  Leu Ser Glu 
    1700                 1705                 1710             


Lys Lys  Tyr Arg Gln His Pro  Glu Lys Leu Lys Phe  Thr Tyr Ala 
    1715                 1720                 1725             


Met Asp  Thr Met Glu Gln Ala  Leu Asn Lys Ser Asn  Lys Leu Asn 
    1730                 1735                 1740             


Met Asp  Lys Arg Leu Tyr Thr  Glu Lys Trp Asn Lys  Asp Lys Thr 
    1745                 1750                 1755             


Thr Ile  His Val Met Pro Asp  Thr Pro Asp Ile Leu  Leu Ser Arg 
    1760                 1765                 1770             


Val Asn  Gln Ile Thr Met Ser  Asp Lys Leu Tyr Lys  Ala Gly Trp 
    1775                 1780                 1785             


Glu Glu  Glu Lys Lys Lys Gly  Tyr Asp Leu Arg Pro  Asp Ala Ile 
    1790                 1795                 1800             


Ala Ile  Lys Ala Ala Arg Ala  Ser Arg Asp Ile Ala  Ser Asp Tyr 
    1805                 1810                 1815             


Lys Tyr  Lys Lys Ala Tyr Glu  Gln Ala Lys Gly Lys  His Ile Gly 
    1820                 1825                 1830             


Phe Arg  Ser Leu Glu Asp Asp  Pro Lys Leu Val His  Phe Met Gln 
    1835                 1840                 1845             


Val Ala  Lys Met Gln Ser Asp  Arg Glu Tyr Lys Lys  Gly Tyr Glu 
    1850                 1855                 1860             


Lys Ser  Lys Thr Ser Phe His  Thr Pro Val Asp Met  Leu Ser Val 
    1865                 1870                 1875             


Val Ala  Ala Lys Lys Ser Gln  Glu Val Ala Thr Asn  Ala Asn Tyr 
    1880                 1885                 1890             


Arg Asn  Val Ile His Thr Tyr  Asn Met Leu Pro Asp  Ala Met Ser 
    1895                 1900                 1905             


Phe Glu  Leu Ala Lys Asn Met  Met Gln Ile Gln Ser  Asp Asn Gln 
    1910                 1915                 1920             


Tyr Lys  Ala Asp Tyr Ala Asp  Phe Met Lys Gly Ile  Gly Trp Leu 
    1925                 1930                 1935             


Pro Leu  Gly Ser Leu Glu Ala  Glu Lys Asn Lys Lys  Ala Met Glu 
    1940                 1945                 1950             


Ile Ile  Ser Glu Lys Lys Tyr  Arg Gln His Pro Asp  Thr Leu Lys 
    1955                 1960                 1965             


Tyr Ser  Thr Leu Met Asp Ser  Met Asn Met Val Leu  Ala Gln Asn 
    1970                 1975                 1980             


Asn Ala  Lys Ile Met Asn Glu  His Leu Tyr Lys Gln  Ala Trp Glu 
    1985                 1990                 1995             


Ala Asp  Lys Thr Lys Val His  Ile Met Pro Asp Ile  Pro Gln Ile 
    2000                 2005                 2010             


Ile Leu  Ala Lys Ala Asn Ala  Ile Asn Met Ser Asp  Lys Leu Tyr 
    2015                 2020                 2025             


Lys Leu  Ser Leu Glu Glu Ser  Lys Lys Lys Gly Tyr  Asp Leu Arg 
    2030                 2035                 2040             


Pro Asp  Ala Ile Pro Ile Lys  Ala Ala Lys Ala Ser  Arg Asp Ile 
    2045                 2050                 2055             


Ala Ser  Asp Tyr Lys Tyr Lys  Tyr Asn Tyr Glu Lys  Gly Lys Gly 
    2060                 2065                 2070             


Lys Met  Val Gly Phe Arg Ser  Leu Glu Asp Asp Pro  Lys Leu Val 
    2075                 2080                 2085             


His Ser  Met Gln Val Ala Lys  Met Gln Ser Asp Arg  Glu Tyr Lys 
    2090                 2095                 2100             


Lys Asn  Tyr Glu Asn Thr Lys  Thr Ser Tyr His Thr  Pro Ala Asp 
    2105                 2110                 2115             


Met Leu  Ser Val Thr Ala Ala  Lys Asp Ala Gln Ala  Asn Ile Thr 
    2120                 2125                 2130             


Asn Thr  Asn Tyr Lys His Leu  Ile His Lys Tyr Ile  Leu Leu Pro 
    2135                 2140                 2145             


Asp Ala  Met Asn Ile Glu Leu  Thr Arg Asn Met Asn  Arg Ile Gln 
    2150                 2155                 2160             


Ser Asp  Asn Glu Tyr Lys Gln  Asp Tyr Asn Glu Trp  Tyr Lys Gly 
    2165                 2170                 2175             


Leu Gly  Trp Ser Pro Ala Gly  Ser Leu Glu Val Glu  Lys Ala Lys 
    2180                 2185                 2190             


Lys Ala  Thr Glu Tyr Ala Ser  Asp Gln Lys Tyr Arg  Gln His Pro 
    2195                 2200                 2205             


Ser Asn  Phe Gln Phe Lys Lys  Leu Thr Asp Ser Met  Asp Met Val 
    2210                 2215                 2220             


Leu Ala  Lys Gln Asn Ala His  Thr Met Asn Lys His  Leu Tyr Thr 
    2225                 2230                 2235             


Ile Asp  Trp Asn Lys Asp Lys  Thr Lys Ile His Val  Met Pro Asp 
    2240                 2245                 2250             


Thr Pro  Asp Ile Leu Gln Ala  Lys Gln Asn Gln Thr  Leu Tyr Ser 
    2255                 2260                 2265             


Gln Lys  Leu Tyr Lys Leu Gly  Trp Glu Glu Ala Leu  Lys Lys Gly 
    2270                 2275                 2280             


Tyr Asp  Leu Pro Val Asp Ala  Ile Ser Val Gln Leu  Ala Lys Ala 
    2285                 2290                 2295             


Ser Arg  Asp Ile Ala Ser Asp  Tyr Lys Tyr Lys Gln  Gly Tyr Arg 
    2300                 2305                 2310             


Lys Gln  Leu Gly His His Val  Gly Phe Arg Ser Leu  Gln Asp Asp 
    2315                 2320                 2325             


Pro Lys  Leu Val Leu Ser Met  Asn Val Ala Lys Met  Gln Ser Glu 
    2330                 2335                 2340             


Arg Glu  Tyr Lys Lys Asp Phe  Glu Lys Trp Lys Thr  Lys Phe Ser 
    2345                 2350                 2355             


Ser Pro  Val Asp Met Leu Gly  Val Val Leu Ala Lys  Lys Cys Gln 
    2360                 2365                 2370             


Glu Leu  Val Ser Asp Val Asp  Tyr Lys Asn Tyr Leu  His Gln Trp 
    2375                 2380                 2385             


Thr Cys  Leu Pro Asp Gln Asn  Asp Val Val Gln Ala  Lys Lys Val 
    2390                 2395                 2400             


Tyr Glu  Leu Gln Ser Glu Asn  Leu Tyr Lys Ser Asp  Leu Glu Trp 
    2405                 2410                 2415             


Leu Arg  Gly Ile Gly Trp Ser  Pro Leu Gly Ser Leu  Glu Ala Glu 
    2420                 2425                 2430             


Lys Asn  Lys Arg Ala Ser Glu  Ile Ile Ser Glu Lys  Lys Tyr Arg 
    2435                 2440                 2445             


Gln Pro  Pro Asp Arg Asn Lys  Phe Thr Ser Ile Pro  Asp Ala Met 
    2450                 2455                 2460             


Asp Ile  Val Leu Ala Lys Thr  Asn Ala Lys Asn Arg  Ser Asp Arg 
    2465                 2470                 2475             


Leu Tyr  Arg Glu Ala Trp Asp  Lys Asp Lys Thr Gln  Ile His Ile 
    2480                 2485                 2490             


Met Pro  Asp Thr Pro Asp Ile  Val Leu Ala Lys Ala  Asn Leu Ile 
    2495                 2500                 2505             


Asn Thr  Ser Asp Lys Leu Tyr  Arg Met Gly Tyr Glu  Glu Leu Lys 
    2510                 2515                 2520             


Arg Lys  Gly Tyr Asp Leu Pro  Val Asp Ala Ile Pro  Ile Lys Ala 
    2525                 2530                 2535             


Ala Lys  Ala Ser Arg Glu Ile  Ala Ser Glu Tyr Lys  Tyr Lys Glu 
    2540                 2545                 2550             


Gly Phe  Arg Lys Gln Leu Gly  His His Ile Gly Ala  Arg Asn Ile 
    2555                 2560                 2565             


Glu Asp  Asp Pro Lys Met Met  Trp Ser Met His Val  Ala Lys Ile 
    2570                 2575                 2580             


Gln Ser  Asp Arg Glu Tyr Lys  Lys Asp Phe Glu Lys  Trp Lys Thr 
    2585                 2590                 2595             


Lys Phe  Ser Ser Pro Val Asp  Met Leu Gly Val Val  Leu Ala Lys 
    2600                 2605                 2610             


Lys Cys  Gln Thr Leu Val Ser  Asp Val Asp Tyr Lys  Asn Tyr Leu 
    2615                 2620                 2625             


His Gln  Trp Thr Cys Leu Pro  Asp Gln Ser Asp Val  Ile His Ala 
    2630                 2635                 2640             


Arg Gln  Ala Tyr Asp Leu Gln  Ser Asp Asn Leu Tyr  Lys Ser Asp 
    2645                 2650                 2655             


Leu Gln  Trp Leu Lys Gly Ile  Gly Trp Met Thr Ser  Gly Ser Leu 
    2660                 2665                 2670             


Glu Asp  Glu Lys Asn Lys Arg  Ala Thr Gln Ile Leu  Ser Asp His 
    2675                 2680                 2685             


Val Tyr  Arg Gln His Pro Asp  Gln Phe Lys Phe Ser  Ser Leu Met 
    2690                 2695                 2700             


Asp Ser  Ile Pro Met Val Leu  Ala Lys Asn Asn Ala  Ile Thr Met 
    2705                 2710                 2715             


Asn His  Arg Leu Tyr Thr Glu  Ala Trp Asp Lys Asp  Lys Thr Thr 
    2720                 2725                 2730             


Val His  Ile Met Pro Asp Thr  Pro Glu Val Leu Leu  Ala Lys Gln 
    2735                 2740                 2745             


Asn Lys  Val Asn Tyr Ser Glu  Lys Leu Tyr Lys Leu  Gly Leu Glu 
    2750                 2755                 2760             


Glu Ala  Lys Arg Lys Gly Tyr  Asp Met Arg Val Asp  Ala Ile Pro 
    2765                 2770                 2775             


Ile Lys  Ala Ala Lys Ala Ser  Arg Asp Ile Ala Ser  Glu Phe Lys 
    2780                 2785                 2790             


Tyr Lys  Glu Gly Tyr Arg Lys  Gln Leu Gly His His  Ile Gly Ala 
    2795                 2800                 2805             


Arg Ala  Ile Arg Asp Asp Pro  Lys Met Met Trp Ser  Met His Val 
    2810                 2815                 2820             


Ala Lys  Ile Gln Ser Asp Arg  Glu Tyr Lys Lys Asp  Phe Glu Lys 
    2825                 2830                 2835             


Trp Lys  Thr Lys Phe Ser Ser  Pro Val Asp Met Leu  Gly Val Val 
    2840                 2845                 2850             


Leu Ala  Lys Lys Cys Gln Thr  Leu Val Ser Asp Val  Asp Tyr Lys 
    2855                 2860                 2865             


Asn Tyr  Leu His Gln Trp Thr  Cys Leu Pro Asp Gln  Ser Asp Val 
    2870                 2875                 2880             


Ile His  Ala Arg Gln Ala Tyr  Asp Leu Gln Ser Asp  Asn Met Tyr 
    2885                 2890                 2895             


Lys Ser  Asp Leu Gln Trp Met  Arg Gly Ile Gly Trp  Val Ser Ile 
    2900                 2905                 2910             


Gly Ser  Leu Asp Val Glu Lys  Cys Lys Arg Ala Thr  Glu Ile Leu 
    2915                 2920                 2925             


Ser Asp  Lys Ile Tyr Arg Gln  Pro Pro Asp Arg Phe  Lys Phe Thr 
    2930                 2935                 2940             


Ser Val  Thr Asp Ser Leu Glu  Gln Val Leu Ala Lys  Asn Asn Ala 
    2945                 2950                 2955             


Ile Thr  Met Asn Lys Arg Leu  Tyr Thr Glu Ala Trp  Asp Lys Asp 
    2960                 2965                 2970             


Lys Thr  Gln Ile His Ile Met  Pro Asp Thr Pro Glu  Ile Met Leu 
    2975                 2980                 2985             


Ala Arg  Gln Asn Lys Ile Asn  Tyr Ser Glu Thr Leu  Tyr Lys Leu 
    2990                 2995                 3000             


Ala Asn  Glu Glu Ala Lys Lys  Lys Gly Tyr Asp Leu  Arg Ser Asp 
    3005                 3010                 3015             


Ala Ile  Pro Ile Val Ala Ala  Lys Ala Ser Arg Asp  Val Ile Ser 
    3020                 3025                 3030             


Asp Tyr  Lys Tyr Lys Asp Gly  Tyr Arg Lys Gln Leu  Gly His His 
    3035                 3040                 3045             


Ile Gly  Ala Arg Asn Ile Glu  Asp Asp Pro Lys Met  Met Trp Ser 
    3050                 3055                 3060             


Met His  Val Ala Lys Ile Gln  Ser Asp Arg Glu Tyr  Lys Lys Asp 
    3065                 3070                 3075             


Phe Glu  Lys Trp Lys Thr Lys  Phe Ser Ser Pro Val  Asp Met Leu 
    3080                 3085                 3090             


Gly Val  Val Leu Ala Lys Lys  Cys Gln Thr Leu Val  Ser Asp Val 
    3095                 3100                 3105             


Asp Tyr  Lys Asn Tyr Leu His  Glu Trp Thr Cys Leu  Pro Asp Gln 
    3110                 3115                 3120             


Asn Asp  Val Ile His Ala Arg  Gln Ala Tyr Asp Leu  Gln Ser Asp 
    3125                 3130                 3135             


Asn Ile  Tyr Lys Ser Asp Leu  Gln Trp Leu Arg Gly  Ile Gly Trp 
    3140                 3145                 3150             


Val Pro  Ile Gly Ser Met Asp  Val Val Lys Cys Lys  Arg Ala Ala 
    3155                 3160                 3165             


Glu Ile  Leu Ser Asp Asn Ile  Tyr Arg Gln Pro Pro  Asp Lys Leu 
    3170                 3175                 3180             


Lys Phe  Thr Ser Val Thr Asp  Ser Leu Glu Gln Val  Leu Ala Lys 
    3185                 3190                 3195             


Asn Asn  Ala Leu Asn Met Asn  Lys Arg Leu Tyr Thr  Glu Ala Trp 
    3200                 3205                 3210             


Asp Lys  Asp Lys Thr Gln Val  His Ile Met Pro Asp  Thr Pro Glu 
    3215                 3220                 3225             


Ile Met  Leu Ala Arg Gln Asn  Lys Ile Asn Tyr Ser  Glu Ser Leu 
    3230                 3235                 3240             


Tyr Arg  Gln Ala Met Glu Glu  Ala Lys Lys Glu Gly  Tyr Asp Leu 
    3245                 3250                 3255             


Arg Ser  Asp Ala Ile Pro Ile  Val Ala Ala Lys Ala  Ser Arg Asp 
    3260                 3265                 3270             


Ile Ala  Ser Asp Tyr Lys Tyr  Lys Glu Ala Tyr Arg  Lys Gln Leu 
    3275                 3280                 3285             


Gly His  His Ile Gly Ala Arg  Ala Val His Asp Asp  Pro Lys Ile 
    3290                 3295                 3300             


Met Trp  Ser Leu His Ile Ala  Lys Val Gln Ser Asp  Arg Glu Tyr 
    3305                 3310                 3315             


Lys Lys  Asp Phe Glu Lys Tyr  Lys Thr Arg Tyr Ser  Ser Pro Val 
    3320                 3325                 3330             


Asp Met  Leu Gly Ile Val Leu  Ala Lys Lys Cys Gln  Thr Leu Val 
    3335                 3340                 3345             


Ser Asp  Val Asp Tyr Lys His  Pro Leu His Glu Trp  Ile Cys Leu 
    3350                 3355                 3360             


Pro Asp  Gln Asn Asp Ile Ile  His Ala Arg Lys Ala  Tyr Asp Leu 
    3365                 3370                 3375             


Gln Ser  Asp Asn Leu Tyr Lys  Ser Asp Leu Glu Trp  Met Lys Gly 
    3380                 3385                 3390             


Ile Gly  Trp Val Pro Ile Asp  Ser Leu Glu Val Val  Arg Ala Lys 
    3395                 3400                 3405             


Arg Ala  Gly Glu Leu Leu Ser  Asp Thr Ile Tyr Arg  Gln Arg Pro 
    3410                 3415                 3420             


Glu Thr  Leu Lys Phe Thr Ser  Ile Thr Asp Thr Pro  Glu Gln Val 
    3425                 3430                 3435             


Leu Ala  Lys Asn Asn Ala Leu  Asn Met Asn Lys Arg  Leu Tyr Thr 
    3440                 3445                 3450             


Glu Ala  Trp Asp Asn Asp Lys  Lys Thr Ile His Val  Met Pro Asp 
    3455                 3460                 3465             


Thr Pro  Glu Ile Met Leu Ala  Lys Leu Asn Arg Ile  Asn Tyr Ser 
    3470                 3475                 3480             


Asp Lys  Leu Tyr Lys Leu Ala  Leu Glu Glu Ser Lys  Lys Glu Gly 
    3485                 3490                 3495             


Tyr Asp  Leu Arg Leu Asp Ala  Ile Pro Ile Gln Ala  Ala Lys Ala 
    3500                 3505                 3510             


Ser Arg  Asp Ile Ala Ser Asp  Tyr Lys Tyr Lys Glu  Gly Tyr Arg 
    3515                 3520                 3525             


Lys Gln  Leu Gly His His Ile  Gly Ala Arg Asn Ile  Lys Asp Asp 
    3530                 3535                 3540             


Pro Lys  Met Met Trp Ser Ile  His Val Ala Lys Ile  Gln Ser Asp 
    3545                 3550                 3555             


Arg Glu  Tyr Lys Lys Glu Phe  Glu Lys Trp Lys Thr  Lys Phe Ser 
    3560                 3565                 3570             


Ser Pro  Val Asp Met Leu Gly  Val Val Leu Ala Lys  Lys Cys Gln 
    3575                 3580                 3585             


Ile Leu  Val Ser Asp Ile Asp  Tyr Lys His Pro Leu  His Glu Trp 
    3590                 3595                 3600             


Thr Cys  Leu Pro Asp Gln Asn  Asp Val Ile Gln Ala  Arg Lys Ala 
    3605                 3610                 3615             


Tyr Asp  Leu Gln Ser Asp Ala  Ile Tyr Lys Ser Asp  Leu Glu Trp 
    3620                 3625                 3630             


Leu Arg  Gly Ile Gly Trp Val  Pro Ile Gly Ser Val  Glu Val Glu 
    3635                 3640                 3645             


Lys Val  Lys Arg Ala Gly Glu  Ile Leu Ser Asp Arg  Lys Tyr Arg 
    3650                 3655                 3660             


Gln Pro  Ala Asp Gln Leu Lys  Phe Thr Cys Ile Thr  Asp Thr Pro 
    3665                 3670                 3675             


Glu Ile  Val Leu Ala Lys Asn  Asn Ala Leu Thr Met  Ser Lys His 
    3680                 3685                 3690             


Leu Tyr  Thr Glu Ala Trp Asp  Ala Asp Lys Thr Ser  Ile His Val 
    3695                 3700                 3705             


Met Pro  Asp Thr Pro Asp Ile  Leu Leu Ala Lys Ser  Asn Ser Ala 
    3710                 3715                 3720             


Asn Ile  Ser Gln Lys Leu Tyr  Thr Lys Gly Trp Asp  Glu Ser Lys 
    3725                 3730                 3735             


Met Lys  Asp Tyr Asp Leu Arg  Ala Asp Ala Ile Ser  Ile Lys Ser 
    3740                 3745                 3750             


Ala Lys  Ala Ser Arg Asp Ile  Ala Ser Asp Tyr Lys  Tyr Lys Glu 
    3755                 3760                 3765             


Ala Tyr  Glu Lys Gln Lys Gly  His His Ile Gly Ala  Gln Ser Ile 
    3770                 3775                 3780             


Glu Asp  Asp Pro Lys Ile Met  Cys Ala Ile His Ala  Gly Lys Ile 
    3785                 3790                 3795             


Gln Ser  Glu Arg Glu Tyr Lys  Lys Glu Phe Gln Lys  Trp Lys Thr 
    3800                 3805                 3810             


Lys Phe  Ser Ser Pro Val Asp  Met Leu Ser Ile Leu  Leu Ala Lys 
    3815                 3820                 3825             


Lys Cys  Gln Thr Leu Val Thr  Asp Ile Asp Tyr Arg  Asn Tyr Leu 
    3830                 3835                 3840             


His Glu  Trp Thr Cys Met Pro  Asp Gln Asn Asp Ile  Ile Gln Ala 
    3845                 3850                 3855             


Lys Lys  Ala Tyr Asp Leu Gln  Ser Asp Ala Leu Tyr  Lys Ala Asp 
    3860                 3865                 3870             


Leu Glu  Trp Leu Arg Gly Ile  Gly Trp Met Pro Gln  Gly Ser Pro 
    3875                 3880                 3885             


Glu Val  Leu Arg Val Lys Asn  Ala Gln Asn Ile Phe  Cys Asp Ser 
    3890                 3895                 3900             


Val Tyr  Arg Thr Pro Val Val  Asn Leu Lys Tyr Thr  Ser Ile Val 
    3905                 3910                 3915             


Asp Thr  Pro Glu Val Val Leu  Ala Lys Ser Asn Ala  Glu Asn Ile 
    3920                 3925                 3930             


Ser Ile  Pro Lys Tyr Arg Glu  Val Trp Asp Lys Asp  Lys Thr Ser 
    3935                 3940                 3945             


Ile His  Ile Met Pro Asp Thr  Pro Glu Ile Asn Leu  Ala Arg Ala 
    3950                 3955                 3960             


Asn Ala  Leu Asn Val Ser Asn  Lys Leu Tyr Arg Glu  Gly Trp Asp 
    3965                 3970                 3975             


Glu Met  Lys Ala Gly Cys Asp  Val Arg Leu Asp Ala  Ile Pro Ile 
    3980                 3985                 3990             


Gln Ala  Ala Lys Ala Ser Arg  
    3995                 4000 


<210>  8483
<211>  1006
<212>  DNA
<213>  Homosapiens

<400>  8483
caaattatta aaaccacaat gagatacccc ttcacacatg ccagaatggt gatgataaaa     60

aagacagaca ataacagaca ttagaaagga tgtggagaaa ttgggtcctt cataaaccac    120

tggtggaagt ggaaaagagt gcagccacct tggaaaagaa tttggcagtt atcacatgtt    180

aaatacagca ttaccctatg gcccagcaaa ttccactcct aggtgtatac ccaagaagaa    240

tgaagacata ggtctgcaca ataatttgta catccatgtc cgtagcagca ttactcataa    300

tagccaaaaa gtggaaacaa cttaaatgcc caccaactga tgaatgcata agcaagatct    360

ggtatatcca tacagatcta ttattgggta gtaacaagaa tggggtagta acaagaatga    420

agtactgaca catgatacaa catggatgaa cttcaaaagt aaaggacgcc atgcaccaag    480

tgtcattctt ggaaacgtgg gagatttagg aaatgacatt gaagaggaag aattctgttg    540

aaatagtgat tctcaacgtg gggtccttgg acagcaagga tgaggaaaaa acacagtcat    600

ccaaggagcc agaagttata tgctgacaaa atgccaccga ctactttagt ggaagctgtt    660

gttgggatag ggaatctgca ccctctagag aagcagggac ttcagctgct gaggaagggc    720

tgtcagagtt atccatgtta ttttttttca tttttgtgag tacggtgcct cctaaacaat    780

cacatgagga tttgagactg ttagaactcg gtgttgttat ccacacaaat ggaaacattc    840

attattttta aaacatgttt gtttgtaaat atcagatgaa gtaaaaaatt gacattaact    900

gtattataga aatgggaaag tatatccttt tgtaatataa gatgtattag aagcaaagaa    960

gggaaatggg cttcaaacaa aaataaataa atgtaaagat cagttt                  1006


<210>  8484
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  8484

Met Thr Leu Lys Arg Lys Asn Ser Val Glu Ile Val Ile Leu Asn Val 
1               5                   10                  15      


Gly Ser Leu Asp Ser Lys Asp Glu Glu Lys Thr Gln Ser Ser Lys Glu 
            20                  25                  30          


Pro Glu Val Ile Cys 
        35          


<210>  8485
<211>  2103
<212>  DNA
<213>  Homosapiens

<400>  8485
atcataaaaa cacgcctttc tcattcaact gaaaaacaca ctaaaatttt aaaagagaaa     60

aatgcaacat cttggaaagt aacgttttaa caccataaaa atttgcactt attcaactga    120

aaatttacac taaaatagac attaactgtg cttttacatt ccaaaccatc atactaaaca    180

taacaagtta attgccaatg ttttccttcc cctatacttt gaggtagttc tacgtaacca    240

actataacaa atttacttcc taacatcctc aatcttctgc tctcctttag ttttaagata    300

ctttatgaca tgggtaatac tctgaaatgg atgccttctt tggatatatt ttggggtttt    360

agtgtctgga ggactttgat ttctatatta gcatattggt ttatgaagtc tggacacaac    420

ctaaggaaaa taatcacttg ttttaaagga cagttctttc aaattcccta caatgtcaga    480

tttagagcca aataccatcg aatatgttga tgctgtaatt cctagcaaat ttcaagaggt    540

cactctcttt tcaaaattat accgtgcccc ttctttgaaa atgagtttca ttttcgaagt    600

caaaacaagt cctttctctt ccactggcgg gcccttctgg tccccagatt agcctgttcc    660

aaaattggtc atgtgtctca ctgggcccct tcagttgacc caagcgtccc tcaccagctc    720

ctatccatct ctatctgctg gaaaggcttt gaggtttcag atttaggaca gcaccactca    780

ttcacggtct ctcctgcatc aggttcttta ttctgatagt ttccggaaac aaatacaagg    840

caaagctgcc tatgtattgg atacccccga gatgagacgg gtgagggaga cccaacggca    900

catctcaacg gtgaaatatc atgaagactt tgagaaacac aagggttgct tcacaccagt    960

ggtgacagat cctatcactg aacgagtaaa gaagaacatg caggacttca gtgacattaa   1020

ctaccgaggt attcagagga aagtggtaga aatggaacaa aaacggaatg accaagatca   1080

ggagactatt acaggtaact gagcctgggt tgggggaggg gattaacttt aagtgagggg   1140

gtagaagaac aaaagtagca ttacctacat caagtcaaaa cataaaggac ttcaatctgt   1200

ttttctagag gtgcaagaaa gctcctatta tctcatagtt tacaaagctg atttctacct   1260

tatctttgtt ctcctctgag gaaaagacat gacccagaac ctaagctgga ataagtgtga   1320

ttcaatcctt tggtggttgt taaaattcat gccttggttt tcaagttatt ggaaaactcc   1380

aagaacactt gttctgatca ctggtttccc tttcaggttt acgtgtctgg cgtactaatc   1440

ctggttcggt ttttgactat gatccagcag aagacaacat ccagtcccga agcttacaca   1500

tgattaatgg tgtgttagct gaaaaaggct tacaacataa acatcaccat ttagtatgct   1560

agagtcaatg actttcattt gggctctgaa gttccttccc tccagagttt tccattttct   1620

gagctgccca tttggcataa aaataccttg ttaactagtg agcaaaactt actttctaga   1680

taagttcaag ttagaaaaaa ttttgtttca ctgcctcagt gcatgtctcc cattattatc   1740

atttctaatt tttcttccaa agaaaaaaca gtagtaattc tattggagaa ataatgaaaa   1800

tacataaaat acataggcaa agggaagaga aaggatttga cctgtaggaa cttcctgagc   1860

tctattgcat caaggaagtt tattcattac acaaagcagg ctgcacaact tcattccttc   1920

ttttcatgtt aaaaagcaga atactagcct ggaaaagaga atgagacccc ttttctacaa   1980

acagtaaaaa aaaattagcc gcgagtggtg ttgtacacct gtagtaccag ctgttcaggg   2040

ggctgaagtg ggaggatagc ttgagcctag aaagttgaag ctgcagtgag ccgtgattgt   2100

acc                                                                 2103


<210>  8486
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  8486

Met Arg Arg Val Arg Glu Thr Gln Arg His Ile Ser Thr Val Lys Tyr 
1               5                   10                  15      


His Glu Asp Phe Glu Lys His Lys Gly Cys Phe Thr Pro Val Val Thr 
            20                  25                  30          


Asp Pro Ile Thr Glu Arg Val Lys Lys Asn Met Gln Asp Phe Ser Asp 
        35                  40                  45              


Ile Asn Tyr Arg Gly Ile Gln Arg Lys Val Val Glu Met Glu Gln Lys 
    50                  55                  60                  


Arg Asn Asp Gln Asp Gln Glu Thr Ile Thr Gly Asn 
65                  70                  75      


<210>  8487
<211>  806
<212>  DNA
<213>  Homosapiens

<400>  8487
acagcagctg tttttttact ggactgtttt gcagcactta aactctcata gacatatcag     60

taaaactgta ggccctcaga caaagcaaag ggtttcccct accctctttt tctttgctat    120

cctctatgct ctgcctcttg ctttagtttc atacaacatt cagcttatca ttaaggaata    180

aggtttttgg ctcttatatc actatcatgg cgaatcagtg gaaaatgaga aacatagtaa    240

cacatcatga taaatcctca acctcggtat ctcccctcag tgtcattctt ggaaacgtgg    300

gagatttagg aaatgacatt gaagaggaag aattctgttg aaatagtgat tctcaacgtg    360

gggtccttgg acagcaagga tgaggaaaaa acacagtcat ccaaggagcc agaagttata    420

tgctgacaaa atgccaccga ctactttagt ggaagctgtt gttgggatag ggaatctgca    480

ccctctagag aagcagggac ttcagctgct gaggaagggc tgtcagagtt atccatgtta    540

ttttttttca tttttgtgag tacggtgcct cctaaacaat cacatgagga tttgagactg    600

ttagaactcg gtgttgttat ccacacaaat ggaaacattc attattttta aaacatgttt    660

gtttgtaaat atcagatgaa gtaaaaaatt gacattaact gtattataga aatgggaaag    720

tatatccttt tgtaatataa gatgtattag aagcaaagaa gggaaatggg cttcaaacaa    780

aaataaataa atgtaaagat cagttt                                         806


<210>  8488
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  8488

Met Thr Leu Lys Arg Lys Asn Ser Val Glu Ile Val Ile Leu Asn Val 
1               5                   10                  15      


Gly Ser Leu Asp Ser Lys Asp Glu Glu Lys Thr Gln Ser Ser Lys Glu 
            20                  25                  30          


Pro Glu Val Ile Cys 
        35          


<210>  8489
<211>  6062
<212>  DNA
<213>  Homosapiens

<400>  8489
gattgaagat agtaagtaga ttcaacagca tgtaaaaggt ctgaatattt aatgttttca     60

tctaatgtgt ctcttgttca attatcacta caactgttgc agggagatga ggattaccgt    120

gcagctctat gaatattgta tatattcatg gcgcctcttg actttgatgc tgaattgcta    180

ggttatttcc agcacatctg atcccacaca cacaggttaa cagtgtctct gataataatg    240

cctttttaga aggccaactg aagcatgcac tttccagcac atgctgaaag gtaaatttga    300

tgcagcaata aacagtgata attggtaact accagacaca atgttagtaa taataccatt    360

tttcccagac caaaaaaaaa aagttaattg agctttcctc atttctcctc ctataaatat    420

cctgtttgcc tgaacttcct cctttgtcct tatatgatcc tcaaatagtt gtgcatgaaa    480

ttttatggtg ctctctgtat ctgtcctgct taaaacagct tctgtgcatg aaaataatta    540

tgacttgaaa attgcaaaaa caaatgaatt ttttaaaatg ataaatactt catatatact    600

cattctttat tttacatccc tgtttcatct ttgacatgga aaaatgcctt tggagattgt    660

acatgttcaa tacaatatgt tatgagtaaa acaatatttg tcagactcca gagaacaggt    720

tctagtcctg ctctgagatt tggtctaaat gtgcccttgg gtcagtctcg taacctctgg    780

gggcctccga gtacatgtgt ataaaacata ttggaacttg ggaggctgag gcagaagaat    840

tgcttgaatc tgggaggtgg aggttgcagt gagccgagat cgcaccactg cactccagcc    900

tgggtgacag agtaagactc cgtctcggag ggaaacaaaa aaaggaaatt attagtagta    960

gtatcatctg ctcactccat ttcacttttg ctatcagaca caaatttata gtaaacattt   1020

ccagttagga attaaagaga aagctagata ccatctccca ctctggtgtt tcaagaggac   1080

aattagatac cttaaagccc actctacaac ttcttagagc tctttcttct cttccacaat   1140

ttagatcaaa tacaggaaaa actatgaaaa atcaaaggac aaatttacct caattgtgga   1200

tactccagaa cacctgcgta ctacaaaagt caacaaacaa atcagcgata tcctttataa   1260

attggaatac aacaaggcca aacccagagg ctacaccaca atccacgaca cacccatgtt   1320

gctgcatgtc cgcaaggtta aagatgaagt cagtgatctg aaatacaaag aagtatacca   1380

aagaaataaa tccaactgca ccattgagcc agatgctgtt catatcaaag cagccaagga   1440

cgcctacaaa gtcaacacca atctggacta taagaaacag tacgaagcca acaaagccca   1500

ctggaagtgg actcctgacc gaccggactt cctccaggct gccaagtcat ccctgcagca   1560

aagcgatttt gaatataagc tggaccggga gttcctcaag ggttgcaagc tttctgtcac   1620

tgatgacaaa aacacggtgc tcgccctcag gaatacttta atagaaagtg atctgaaata   1680

caaagagaaa catgtcaagg aaagaggaac ctgccatgcc gtacctgaca cgcctcagat   1740

cctgctggcg aagactgtca gcaacctggt gtctgagaac aagtacaagg accatgtcaa   1800

gaagcacttg gcacagggct catacacaac actaccagag acccgggaca ctgttcacgt   1860

caaggaagtg accaagcatg tcagtgatac aaattacaaa aagaagtttg tcaaggagaa   1920

aggaaaatcc aactactcca tcatgctgga gccaccagag gtgaaacatg ctatggaagt   1980

ggccaagaag caaagtgatg tcgcttacag aaaagatgcc aaagagaacc tgcattacac   2040

cacagtggct gatcgaccag acatcaagaa ggccacacag gcagccaaac aggccagtga   2100

ggtggagtac agagccaagc accgcaagga aggcagccat ggcttaagca tgctcggtcg   2160

cccagacata gaaatggcca agaaggcagc caagctgagc agccaggtta aataccgaga   2220

aaatttcgat aaagaaaagg gcaagacacc aaaatacaat ccaaaagaca gccagctcta   2280

caaagtcatg aaagatgcta ataatcttgc aagtgaggtt aaatacaagg ctgacctgaa   2340

gaaacttcac aaacccgtga ctgacatgaa ggagtctctg atcatgaatc atgtcctgaa   2400

tacaagccaa cttgccagtt cttaccagta caagaagaag tatgagaaga gtaaaggcca   2460

ctaccacacc atacccgata atctggagca gcttcaccta aaagaggcca cagaattaca   2520

gagtatagtg aaatacaaag aaaagtatga aaaggaacga ggaaaaccca tgctggactt   2580

tgaaacacca acgtacatca ctgccaaaga gtctcagcag atgcagagtg ggaaagaata   2640

taggaaagat tatgaagagt ccattaaagg cagaaacctg actggcctgg aggtcacgcc   2700

agctttgtta catgtcaaat atgcaactaa aatagcaagc gagaaagagt acaggaaaga   2760

tctagaggaa agcatccgtg ggaagggcct cactgaaatg gaagatacac ctgacatgct   2820

aagagcaaag aatgccactc aaatcctcaa tgagaaagaa tataagcgag acctggaact   2880

ggaagtcaaa ggaagaggcc tgaatgccat ggccaatgaa actccggatt ttatgagggc   2940

caggaatgct actgatattg ccagtcagat taagtataag caatcagcag aaatggagaa   3000

agccaatttc acttctgtgg ttgatactcc agagatcatt catgcccaac aagtcaagaa   3060

tctttcaagc cagaaaaagt acaaggaaga tgctgagaag tccatgtcgt attatgagac   3120

tgttttggac accccagaga tacagagagt ccgggagaac caaaagaact tcagccttct   3180

ccaataccag tgtgacctta aaaacagtaa aggaaaaatt acagttgttc aagacacgcc   3240

agaaatactg cgtgtaaaag aaaatcagaa gaatttcagc tcggttttat ataaagagga   3300

tgtctcacca ggaacggcta tcggaaagac acctgagatg atgagagtga aacaaacaca   3360

ggaccacatt agctcggtga agtataagga agcaatagga caaggaactc caatccctga   3420

cctgcctgaa gtgaaacgtg tgaaggagac gcagaagcac attagctcgg ttatgtacaa   3480

agaaaacttg ggaacaggca ttccaaccac tgtgactcca gagattgaga gagtcaaacg   3540

caatcaagag aactttagct cgatattgta caaagagaac ttgagcaagg ggactcccct   3600

acctgtcact cctgagatgg agcgagtcaa actcaatcaa gaaaacttta gctcggtgct   3660

atacaaagaa aacctgggga caggaattcc aatccccatc actcctgaga tgcagagagt   3720

caaacacaat caagaaaacc ttagctcggt attttggaaa gaaaggggaa aaaatgccac   3780

ttaacttcag aattaaactg atctttacat ttatttattt ttgtttgaag cccatttccc   3840

ttctttgctt ctaatacatc ttatattaca aaaggatata ctttcccatt tctataatac   3900

agttaatgtc aattttttac ttcatctgat atttacaaac aaacatgttt taaaaataat   3960

gaatgtttcc atttgtgtgg ataacaacac cgagttctaa cagtctcaaa tcctcatgtg   4020

attgtttagg aggcaccgta ctcacaaaaa tgaaaaaaaa taacatggat aactctgaca   4080

gcccttcctc agcagctgaa gtccctgctt ctctagaggg tgcagattcc ctatcccaac   4140

aacagcttcc actaaagtag tcggtggcat tttgtcagca tataacttct ggctccttgg   4200

atgactgtgt tttttcctca tccttaaaaa gtcccaagaa atgaaatgtt actcatggtt   4260

gtttttctgg atgctttctt atcgcacagg tgttatacaa agaaaacatg ggcaagggaa   4320

cccctttacc tgtcactccc gagatggaaa gagtcaaaca caatcaagaa aatattagct   4380

cggtactttg gcaagaaaag aaaaaaacta cttatttaat gattttgaaa actttcatga   4440

tttaaaataa tacgtattaa tcctactttt taaagacaac ttaaattttg tgaatttctt   4500

tagcaaattt atcctttttt cctttgggct acttctagcc taacaccatt cccatttcta   4560

taatacagtt aatttcaatt ttttatttca tctggtattt tcaatctttt ttttaaaata   4620

atgagttttt cagtttgtgt ggataacacc actgagttct aactgtctca aatcctcata   4680

taattgttta ggaggcatgg tactcacaaa aaaggaaaaa aaaaaataac atggataact   4740

ctgacagcct ttccccagca gctgaggtcc ctgcttctct agagggtgca gattccccat   4800

cccaacaact tccactaaag taaagtagtc ggtggcattt tgtcagcata taacttctgg   4860

ctccttggac aactgtgttt tgtcttaaca aggaagctga ccttaccctt aaaacctttc   4920

aacaaatgaa atgttactca tggttgtttt tctggttgct ttcttatcgc acaggtgtta   4980

tacaaagaaa acatgggcaa gggaacccct ctacctgtca ctcctgagat ggagagagtc   5040

aaacacaatc aagaaaatat tagctcggta cttgggcaag aaaagaaaaa aactacttac   5100

tgattttaaa aactatttca tgatttaaaa taatacatat taatcctatt ttctaaagac   5160

aaattttgtg aacttctttc tttagcaaat ttatcctttt ttcctttggg ctacttctag   5220

cctaacacca tttccataat acagttaatt ttgatttttt atttcatctg atattttcaa   5280

tcatttttta aaaatgagtt tttccgtttg tgtggataac aacactgagt tctaacagtc   5340

tcaaatcctc atgtgattgt ttaggaggca ccgtactcac aaaaatgaaa aaaaataaca   5400

tggataactc tgacagcctt tccccagcag ctgaggtccc tgcttctcta gagggtgcag   5460

attccccatc ccaacaacag cttccactaa agtagctggt ggcattttgt cagcatataa   5520

cttctggctc cttggacgac tgtgttttct taacaaggaa gttgacctta cccttaaaac   5580

ctctcaacaa atgaaatgtt actcatggtt gtttttctgg atgctttctc atcgcacagg   5640

tgttatacaa agaaaacatg ggcaagggaa ctcctttagc tgtcactccc gagatggagc   5700

gagtcaaaca caatcaagaa aatattagct cggtacttgg cgagaaaaga aaaaaactac   5760

ttactgattt taaaaactac ttttatgatt taaaataata catattaatc ctacttttta   5820

aagacaactt aaattttgtg aaatttcttt agcaaattta cccttttttc ctttgggcta   5880

cttctagcct aaccccataa taacaaggtt gctttaatcc ataaagttct aatatcaaga   5940

agtaacagat tttcctataa aacatccttt tgcttctctc tctccaaact tactctctat   6000

ccactacccc caaggtctct ttgttttaga tatgcttgaa atttaggacg ggtacgtgtg   6060

gg                                                                  6062


<210>  8490
<211>  822
<212>  PRT
<213>  Homosapiens

<400>  8490

Met Leu Leu His Val Arg Lys Val Lys Asp Glu Val Ser Asp Leu Lys 
1               5                   10                  15      


Tyr Lys Glu Val Tyr Gln Arg Asn Lys Ser Asn Cys Thr Ile Glu Pro 
            20                  25                  30          


Asp Ala Val His Ile Lys Ala Ala Lys Asp Ala Tyr Lys Val Asn Thr 
        35                  40                  45              


Asn Leu Asp Tyr Lys Lys Gln Tyr Glu Ala Asn Lys Ala His Trp Lys 
    50                  55                  60                  


Trp Thr Pro Asp Arg Pro Asp Phe Leu Gln Ala Ala Lys Ser Ser Leu 
65                  70                  75                  80  


Gln Gln Ser Asp Phe Glu Tyr Lys Leu Asp Arg Glu Phe Leu Lys Gly 
                85                  90                  95      


Cys Lys Leu Ser Val Thr Asp Asp Lys Asn Thr Val Leu Ala Leu Arg 
            100                 105                 110         


Asn Thr Leu Ile Glu Ser Asp Leu Lys Tyr Lys Glu Lys His Val Lys 
        115                 120                 125             


Glu Arg Gly Thr Cys His Ala Val Pro Asp Thr Pro Gln Ile Leu Leu 
    130                 135                 140                 


Ala Lys Thr Val Ser Asn Leu Val Ser Glu Asn Lys Tyr Lys Asp His 
145                 150                 155                 160 


Val Lys Lys His Leu Ala Gln Gly Ser Tyr Thr Thr Leu Pro Glu Thr 
                165                 170                 175     


Arg Asp Thr Val His Val Lys Glu Val Thr Lys His Val Ser Asp Thr 
            180                 185                 190         


Asn Tyr Lys Lys Lys Phe Val Lys Glu Lys Gly Lys Ser Asn Tyr Ser 
        195                 200                 205             


Ile Met Leu Glu Pro Pro Glu Val Lys His Ala Met Glu Val Ala Lys 
    210                 215                 220                 


Lys Gln Ser Asp Val Ala Tyr Arg Lys Asp Ala Lys Glu Asn Leu His 
225                 230                 235                 240 


Tyr Thr Thr Val Ala Asp Arg Pro Asp Ile Lys Lys Ala Thr Gln Ala 
                245                 250                 255     


Ala Lys Gln Ala Ser Glu Val Glu Tyr Arg Ala Lys His Arg Lys Glu 
            260                 265                 270         


Gly Ser His Gly Leu Ser Met Leu Gly Arg Pro Asp Ile Glu Met Ala 
        275                 280                 285             


Lys Lys Ala Ala Lys Leu Ser Ser Gln Val Lys Tyr Arg Glu Asn Phe 
    290                 295                 300                 


Asp Lys Glu Lys Gly Lys Thr Pro Lys Tyr Asn Pro Lys Asp Ser Gln 
305                 310                 315                 320 


Leu Tyr Lys Val Met Lys Asp Ala Asn Asn Leu Ala Ser Glu Val Lys 
                325                 330                 335     


Tyr Lys Ala Asp Leu Lys Lys Leu His Lys Pro Val Thr Asp Met Lys 
            340                 345                 350         


Glu Ser Leu Ile Met Asn His Val Leu Asn Thr Ser Gln Leu Ala Ser 
        355                 360                 365             


Ser Tyr Gln Tyr Lys Lys Lys Tyr Glu Lys Ser Lys Gly His Tyr His 
    370                 375                 380                 


Thr Ile Pro Asp Asn Leu Glu Gln Leu His Leu Lys Glu Ala Thr Glu 
385                 390                 395                 400 


Leu Gln Ser Ile Val Lys Tyr Lys Glu Lys Tyr Glu Lys Glu Arg Gly 
                405                 410                 415     


Lys Pro Met Leu Asp Phe Glu Thr Pro Thr Tyr Ile Thr Ala Lys Glu 
            420                 425                 430         


Ser Gln Gln Met Gln Ser Gly Lys Glu Tyr Arg Lys Asp Tyr Glu Glu 
        435                 440                 445             


Ser Ile Lys Gly Arg Asn Leu Thr Gly Leu Glu Val Thr Pro Ala Leu 
    450                 455                 460                 


Leu His Val Lys Tyr Ala Thr Lys Ile Ala Ser Glu Lys Glu Tyr Arg 
465                 470                 475                 480 


Lys Asp Leu Glu Glu Ser Ile Arg Gly Lys Gly Leu Thr Glu Met Glu 
                485                 490                 495     


Asp Thr Pro Asp Met Leu Arg Ala Lys Asn Ala Thr Gln Ile Leu Asn 
            500                 505                 510         


Glu Lys Glu Tyr Lys Arg Asp Leu Glu Leu Glu Val Lys Gly Arg Gly 
        515                 520                 525             


Leu Asn Ala Met Ala Asn Glu Thr Pro Asp Phe Met Arg Ala Arg Asn 
    530                 535                 540                 


Ala Thr Asp Ile Ala Ser Gln Ile Lys Tyr Lys Gln Ser Ala Glu Met 
545                 550                 555                 560 


Glu Lys Ala Asn Phe Thr Ser Val Val Asp Thr Pro Glu Ile Ile His 
                565                 570                 575     


Ala Gln Gln Val Lys Asn Leu Ser Ser Gln Lys Lys Tyr Lys Glu Asp 
            580                 585                 590         


Ala Glu Lys Ser Met Ser Tyr Tyr Glu Thr Val Leu Asp Thr Pro Glu 
        595                 600                 605             


Ile Gln Arg Val Arg Glu Asn Gln Lys Asn Phe Ser Leu Leu Gln Tyr 
    610                 615                 620                 


Gln Cys Asp Leu Lys Asn Ser Lys Gly Lys Ile Thr Val Val Gln Asp 
625                 630                 635                 640 


Thr Pro Glu Ile Leu Arg Val Lys Glu Asn Gln Lys Asn Phe Ser Ser 
                645                 650                 655     


Val Leu Tyr Lys Glu Asp Val Ser Pro Gly Thr Ala Ile Gly Lys Thr 
            660                 665                 670         


Pro Glu Met Met Arg Val Lys Gln Thr Gln Asp His Ile Ser Ser Val 
        675                 680                 685             


Lys Tyr Lys Glu Ala Ile Gly Gln Gly Thr Pro Ile Pro Asp Leu Pro 
    690                 695                 700                 


Glu Val Lys Arg Val Lys Glu Thr Gln Lys His Ile Ser Ser Val Met 
705                 710                 715                 720 


Tyr Lys Glu Asn Leu Gly Thr Gly Ile Pro Thr Thr Val Thr Pro Glu 
                725                 730                 735     


Ile Glu Arg Val Lys Arg Asn Gln Glu Asn Phe Ser Ser Ile Leu Tyr 
            740                 745                 750         


Lys Glu Asn Leu Ser Lys Gly Thr Pro Leu Pro Val Thr Pro Glu Met 
        755                 760                 765             


Glu Arg Val Lys Leu Asn Gln Glu Asn Phe Ser Ser Val Leu Tyr Lys 
    770                 775                 780                 


Glu Asn Leu Gly Thr Gly Ile Pro Ile Pro Ile Thr Pro Glu Met Gln 
785                 790                 795                 800 


Arg Val Lys His Asn Gln Glu Asn Leu Ser Ser Val Phe Trp Lys Glu 
                805                 810                 815     


Arg Gly Lys Asn Ala Thr 
            820         


<210>  8491
<211>  650
<212>  DNA
<213>  Homosapiens

<400>  8491
ctctctccat ctctggagtg ataggtgttg ggattccttt ccccaaattt tctttgtaca     60

aaacctgtga gatacaagaa agtacccaga ggacatttaa aacaggcaca gagagtaagg    120

aaggaaggaa atgggggaag gggttatatg tgaggaggca gttttttagt aagtaatatt    180

tagtaaggat aatgttttta cttttttcac agttttaatg atgaactcta caatgctaat    240

tctggaaatg aaaaagtaca atggaaagca ttaagttata taacgctgag gaatcttgtt    300

aattctactt atagtatttc aaatctagtc aagtcactga aaatgttcaa gtataatcgg    360

aaatgtgtct ttccgatagc cgttcctggt gagacatcct ctttatataa aacctgggca    420

ttcagaatca ggacagtgtt aacacagaag aaaagaaaac ccagcagttc ctggagaaag    480

actaggacac atggcttttg tgaaaacaag acactagacg atgttcccag gtcacactgg    540

tattggagct atgaagaaag agtaaacatc ttgttaagat ttcaacattg ctttgttttc    600

tttatttgtc ctatattatg tgaagaaaat taaaatcctg tatctttaaa               650


<210>  8492
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  8492

Met Phe Lys Tyr Asn Arg Lys Cys Val Phe Pro Ile Ala Val Pro Gly 
1               5                   10                  15      


Glu Thr Ser Ser Leu Tyr Lys Thr Trp Ala Phe Arg Ile Arg Thr Val 
            20                  25                  30          


Leu Thr Gln Lys Lys Arg Lys Pro Ser Ser Ser Trp Arg Lys Thr Arg 
        35                  40                  45              


Thr His Gly Phe Cys Glu Asn Lys Thr Leu Asp Asp Val Pro Arg Ser 
    50                  55                  60                  


His Trp Tyr Trp Ser Tyr Glu Glu Arg Val Asn Ile Leu Leu Arg Phe 
65                  70                  75                  80  


Gln His Cys Phe Val Phe Phe Ile Cys Pro Ile Leu Cys Glu Glu Asn 
                85                  90                  95      


<210>  8493
<211>  352
<212>  DNA
<213>  Homosapiens

<400>  8493
caacaatgct ggtgaatttg agggcctcag gctttatacg atacagcctt tcattcaaga     60

gattctgggc attcttcact ctcatcactt ccacagaacc ctctggcagc catccaatac    120

ccttcagcca ttccaggtct gacttgtaca agttatcgct ctgcaggtcg taggctttct    180

tggcctggat cacatcgttc tgatctggca gacacgtcca ctggtgcaga taattgcgat    240

aatcaatgtc gctaaccagg acctggcatt tcttggcttg aacaattgac atcatgtcca    300

acggtgtgtt gtgaattcct ttagacttct cataagcttt cttatattct ct            352


<210>  8494
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  8494

Met Leu Val Asn Leu Arg Ala Ser Gly Phe Ile Arg Tyr Ser Leu Ser 
1               5                   10                  15      


Phe Lys Arg Phe Trp Ala Phe Phe Thr Leu Ile Thr Ser Thr Glu Pro 
            20                  25                  30          


Ser Gly Ser His Pro Ile Pro Phe Ser His Ser Arg Ser Asp Leu Tyr 
        35                  40                  45              


Lys Leu Ser Leu Cys Arg Ser 
    50                  55  


<210>  8495
<211>  353
<212>  DNA
<213>  Homosapiens

<400>  8495
tttttttttt tttgtagcgc ttatatactg aagcctggga caatgacaag aaaactattc     60

atgtcatgcc tgatacacca gaaatcatgt tagccaaact caaccgaata aactacagtg    120

ataaactcta taaacttgct ttggaagagt ccaagaagga aggctatgac ttgcgtctgg    180

atgccattcc aatccaagca gccaaggctt caagagatat tgctagtgat gtaagtggat    240

gttttggaaa agccatttct tattcaaaga tgttgacaaa tagaagcttt tagagttttt    300

cttgctagaa atttagttac ccctataagt ctcaattccc tttagtgatt ttc           353


<210>  8496
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  8496

Met Pro Asp Thr Pro Glu Ile Met Leu Ala Lys Leu Asn Arg Ile Asn 
1               5                   10                  15      


Tyr Ser Asp Lys Leu Tyr Lys Leu Ala Leu Glu Glu Ser Lys Lys Glu 
            20                  25                  30          


Gly Tyr Asp Leu Arg Leu Asp Ala Ile Pro Ile Gln Ala Ala Lys Ala 
        35                  40                  45              


Ser Arg Asp Ile Ala Ser Asp Val Ser Gly Cys Phe Gly Lys Ala Ile 
    50                  55                  60                  


Ser Tyr Ser Lys Met Leu Thr Asn Arg Ser Phe 
65                  70                  75  


<210>  8497
<211>  392
<212>  DNA
<213>  Homosapiens

<400>  8497
caggcaaagc ctttcttttt ggaaagaatt gcaaaacaca gggttctgta tgtcagaagc     60

tacagaacag acgtgggagt tttctcaggg agcccagagg gagccatcca atgcccttca    120

tgaagtcagc atagtcagcc ttgtactgat tctgcaaaag aggaaaaatt aaattatgag    180

aagaaactgg aacttcccaa gaatcctaag tgtgtgttta acattctgta acttccattt    240

catttgtaaa ttttctgtaa cttttccact tcaatatttg cttgaatatt ggtatttaac    300

caatagcatg ttgaacttca accatttctt ccctaaactt ttatcctttt tatatttcct    360

tgcatgataa attaaaaata agcagaaatg tc                                  392


<210>  8498
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  8498

Met Ser Glu Ala Thr Glu Gln Thr Trp Glu Phe Ser Gln Gly Ala Gln 
1               5                   10                  15      


Arg Glu Pro Ser Asn Ala Leu His Glu Val Ser Ile Val Ser Leu Val 
            20                  25                  30          


Leu Ile Leu Gln Lys Arg Lys Asn 
        35                  40  


<210>  8499
<211>  428
<212>  DNA
<213>  Homosapiens

<400>  8499
atgaagctct cagttcagag atcaagatga ttgggggata agaagaagaa aaacattcct     60

gcaggactgg tctgggcaga agaggagttg tggtaactag atatgaggag aaagagagga    120

aggaggcaca gagcagttgg agcttgctgc ctggaagaat gacgttttag agacaaggtc    180

tgactgtgtt gcccaggctg gacttcaact cctcagtaca agtgatcctc ctgcctgagc    240

ctcctgaata gctgggacta caggcctgca ccaccatacc ctgctctagt tacacaaatc    300

ttaaaatgat gctgttatgt taattcaatt aagaaagtaa actagttcta tgatccaagc    360

acatagttgt gactcaattc atgttgttgt ttttaatcct gaaatgatat tgtaaaataa    420

gagctttg                                                             428


<210>  8500
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  8500

Gly Glu Arg Glu Glu Gly Gly Thr Glu Gln Leu Glu Leu Ala Ala Trp 
1               5                   10                  15      


Lys Asn Asp Val Leu Glu Thr Arg Ser Asp Cys Val Ala Gln Ala Gly 
            20                  25                  30          


Leu Gln Leu Leu Ser Thr Ser Asp Pro Pro Ala 
        35                  40              


<210>  8501
<211>  577
<212>  DNA
<213>  Homosapiens

<400>  8501
cttgagccca ggagttcaag gctgcggcga gctgtgtttg cactccagcc taggtgtcag     60

agtgagacta tgtctttaaa aaaaaaaaaa agaagaaaga aatgtattat aacattagga    120

gttgtaggcg gcaacattac aaccagtatt tttctgatta cgattttgta tgttacagat    180

attctatatt gagcgcatta taccaataat cagaaaacat tgctgaatca ttttgtcttt    240

aaagaatcat ctaataggga tgggaaggaa tacaaaagtt gtattaagta aatgggatga    300

agctctcagt tcagagatca agatgattgg gggataagaa gaagaaaaac attcctgcag    360

gactggtctg ggcagaagag gagttgtggt aactagatat gaggagaaag agaggaagga    420

ggcacagagc agttggagct tgctgcctgg aagaatgacg gtatgataaa gagatgggat    480

gatgtgaaat aattcacatt gttaattatg aagtgtgttt tgaatcacct cagtgttacc    540

cagaaacgac actcggttat catgttcaga tagggga                             577


<210>  8502
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  8502

Met Ser Leu Lys Lys Lys Lys Arg Arg Lys Lys Cys Ile Ile Thr Leu 
1               5                   10                  15      


Gly Val Val Gly Gly Asn Ile Thr Thr Ser Ile Phe Leu Ile Thr Ile 
            20                  25                  30          


Leu Tyr Val Thr Asp Ile Leu Tyr 
        35                  40  


<210>  8503
<211>  2729
<212>  DNA
<213>  Homosapiens

<400>  8503
ggagctgggg gaggacggtg gcccgcgagg ctcgtcgcag acaacgcggc ggcgatgtcc     60

gcgagccaga gcacaaagtt atcattgttg ggctggataa tgcagggaaa actaccattc    120

tttaccaatt ttctatgaat gaagttgtac atacatctcc tacaatagga agtaatgtag    180

aagagatagt gattaataat acacgtttcc taatgtggga tattggtggc caagaatctc    240

ttcgttcttc ctggaacact tactatacta acacagagtt tgtaatagtt gttgtggaca    300

gtacagacag agagaggatt tctgtaacta gagaagaact ctataaaatg ttagcgcatg    360

aggacctaag aaaagctgga ttgctgattt ttgctaataa acaagatgtt aaagaatgca    420

tgactgtagc agaaatctcc cagtttttga agaccactta tttgaaaaca aagatgaagt    480

ctcaccttcc agtttgcttt ctcattagtt ttttccaaag taagttattg aagctgtgat    540

tgacattttt ctcataatga atcctctcag gacattgtgt agcctatggt aagtacaaag    600

ggagaggaag acattttgaa ttttaagagc tttattatca gtttaaccct ccctagttga    660

atgttatttt cttcttgttc cattaagtca gaatacaaat cagcacagat attcgaatgt    720

ttccaatatt ttaaaatgta atgttactta tgaaaagtat tttgcttaag gttgtgtgtg    780

tattgtgtat atacctcaag ttcaagttaa tggcattgat ttatgttcca gacaaaaata    840

acacaaataa taatatcctt cgttataacc acaatgagat aagtattggc attagtgttc    900

agtgccattt tatactttct ctctgtgttc tctgtattgt actaaccaac ctcccaaatc    960

gctgagctgc ttgtttaaaa aaaaaaaaaa ggaaaaggaa aaagcatgac attgtgtatc   1020

gattttttgt tgttgaccaa aatcacacac atggaaacat gtaattcaac agagtgggaa   1080

agctagcaga ttcttggctt agtattacta ataggcagga ttgtacaatg agcaactatc   1140

agattattcc tttcagtggt tcttatggca tctaaattac tgaataaatt attaatccat   1200

taatcagtga atcaaattat gattacaatt atcaaatgaa tgctcagcat taattgaaaa   1260

ctgttttgtg aaacatgtct acccagaaaa gtagcattct ataaatacta ttaaacaact   1320

tagctatatt atttttaagt attaaattat atgtcaagca gttaaagtga atttcagagt   1380

aaaagtaagg catgtttctg agcaacattg ataatttctt aatttgcaaa tttcttctta   1440

ttttggtact tggaatatag tgtgagattt tttatttcta aattttgttg tatcttctat   1500

tacataaatg cattgacaat tataaaatgc aagtgttttt tgaatgattt taagaatttg   1560

gcttaaaaat tgattgatac aacgtattat ttgtactaag aagtaacttg acccaaaaca   1620

ccttttatgt ttgcttaggg tatatttttt cagtgtctga aagtcaaagg tattcctgtc   1680

acaactgtaa acaaacttat cctaaatgtg ttaaaacata ttcttgggta ctctatttat   1740

gtatctttca tgccttgaaa atctgaaggt taatccaaac tcacatgttt tagcatattt   1800

gagaaaaaaa aactaccttc aatatcagcc ttttaaattt catgaagatt ttggtgagga   1860

ataatagtat atagtttaag tattgacaaa actttgaaag tttctttctt taaaatggga   1920

aatactcaat atctaaatcc aggtcaggca tgggatatca gtatttaaca ttggatgttt   1980

tatgttttat atttataatg ttcaaaatgc aagcataaca tttaatattt gtccacatgg   2040

ttttacaaaa gtaaatctta aattactaag cttttcccat atgttctcgt actttctcaa   2100

atccctataa agaattactt gttatctatt aaaaatctcc tttacccaaa tctgtattat   2160

ggtttcgcca gacaaatatt atgtgatgta gcccagaaaa tccacacctt ttgtcctttt   2220

tatgttttaa tttgaataat catgtgctta gtcccttgga ttactgccac atcagtttaa   2280

cacgatatca gcacattccc ttgtcatcat caaggtgttg gctcagattt attcttaatt   2340

ggatgtttaa agcatgtact accttgttac agttggttta gtgtagtgga ttattgacat   2400

gacatcatga gaagatgtgt aattttatac cacatttata aaacatgatt ttgttttcta   2460

cccttcaagg taaacattaa aaataaggtg gtacttgtgt acttgtacat aaaaccaaaa   2520

ttatagttgg gaaaaaaata aatttatata tgaaaatgtc aaaatcattt taaaagtatt   2580

attttcaaat aaaatggaga agctggtgaa aagtcatatt ggcaattttt atgtagttta   2640

agtggaatta agcagaggga gatgcttttg ggtttttaat atgccacttc tgagtgaaaa   2700

catctcgtgg agtcattgtg ttcagctct                                     2729


<210>  8504
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  8504

Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Thr Asn Thr Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Thr Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp Val Lys Glu Cys Met 
                85                  90                  95      


Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Thr Thr Tyr Leu Lys Thr 
            100                 105                 110         


Lys Met Lys Ser His Leu Pro Val Cys Phe Leu Ile Ser Phe Phe Gln 
        115                 120                 125             


Ser Lys Leu Leu Lys Leu 
    130                 


<210>  8505
<211>  2989
<212>  DNA
<213>  Homosapiens

<400>  8505
ccgcagccgc ccgagaggag ctgggggagg acggtggccc gcgaggctcg tcgcagacaa     60

cgcggcggcg atgtccgcga gccagagcac aaagttatca ttgttgggct ggataatgca    120

gggaaaacta ccattcttta ccaattttct atgaatgaag ttgtacatac atctcctaca    180

ataggaagta atgtagaaga gatagtgatt aataatacac gtttcctaat gtgggatatt    240

ggtggccaag aatctcttcg ttcttcctgg aacacttact atactaacac agagtttgta    300

atagttgttg tggacagtac agacagagag aggatttctg taactagaga agaactctat    360

aaaatgttag cgcatgagga cctaagaaaa gctggattgc tgatttttgc taataaacaa    420

gatgttaaag aatgcatgac tgtagcagaa atctcccagt ttttgaagct aacttctatt    480

aaagatcacc agtggcatat ccaggcatgc tgtgctctaa ctggcgaggg attgtgccaa    540

ggacttgaat ggatgatgtc acgacttaag attagatgat ctctactgac ctcttctcat    600

agattttgta taaatgaagt gctggacttt acctgaaagc tgcaaaaatt aatggtttag    660

atatatttat aataaactga tttaaacttt ttctataaga agaaaaatta agaccactta    720

tttgaaaaca aagatgaagt ctcaccttcc agtttgcttt ctcattagtt ttttccaaag    780

taagttattg aagctgtgat tgacattttt ctcataatga atcctctcag gacattgtgt    840

agcctatggt aagtacaaag ggagaggaag acattttgaa ttttaagagc tttattatca    900

gtttaaccct ccctagttga atgttatttt cttcttgttc cattaagtca gaatacaaat    960

cagcacagat attcgaatgt ttccaatatt ttaaaatgta atgttactta tgaaaagtat   1020

tttgcttaag gttgtgtgtg tattgtgtat atacctcaag ttcaagttaa tggcattgat   1080

ttatgttcca gacaaaaata acacaaataa taatatcctt cgttataacc acaatgagat   1140

aagtattggc attagtgttc agtgccattt tatactttct ctctgtgttc tctgtattgt   1200

actaaccaac ctcccaaatc gctgagctgc ttgtttaaaa aaaaaaaaaa ggaaaaggaa   1260

aaagcatgac attgtgtatc gattttttgt tgttgaccaa aatcacacac atggaaacat   1320

gtaattcaac agagtgggaa agctagcaga ttcttggctt agtattacta ataggcagga   1380

ttgtacaatg agcaactatc agattattcc tttcagtggt tcttatggca tctaaattac   1440

tgaataaatt attaatccat taatcagtga atcaaattat gattacaatt atcaaatgaa   1500

tgctcagcat taattgaaaa ctgttttgtg aaacatgtct acccagaaaa gtagcattct   1560

ataaatacta ttaaacaact tagctatatt atttttaagt attaaattat atgtcaagca   1620

gttaaagtga atttcagagt aaaagtaagg catgtttctg agcaacattg ataatttctt   1680

aatttgcaaa tttcttctta ttttggtact tggaatatag tgtgagattt tttatttcta   1740

aattttgttg tatcttctat tacataaatg cattgacaat tataaaatgc aagtgttttt   1800

tgaatgattt taagaatttg gcttaaaaat tgattgatac aacgtattat ttgtactaag   1860

aagtaacttg acccaaaaca ccttttatgt ttgcttaggg tatatttttt cagtgtctga   1920

aagtcaaagg tattcctgtc acaactgtaa acaaacttat cctaaatgtg ttaaaacata   1980

ttcttgggta ctctatttat gtatctttca tgccttgaaa atctgaaggt taatccaaac   2040

tcacatgttt tagcatattt gagaaaaaaa aactaccttc aatatcagcc ttttaaattt   2100

catgaagatt ttggtgagga ataatagtat atagtttaag tattgacaaa actttgaaag   2160

tttctttctt taaaatggga aatactcaat atctaaatcc aggtcaggca tgggatatca   2220

gtatttaaca ttggatgttt tatgttttat atttataatg ttcaaaatgc aagcataaca   2280

tttaatattt gtccacatgg ttttacaaaa gtaaatctta aattactaag cttttcccat   2340

atgttctcgt actttctcaa atccctataa agaattactt gttatctatt aaaaatctcc   2400

tttacccaaa tctgtattat ggtttcgcca gacaaatatt atgtgatgta gcccagaaaa   2460

tccacacctt ttgtcctttt tatgttttaa tttgaataat catgtgctta gtcccttgga   2520

ttactgccac atcagtttaa cacgatatca gcacattccc ttgtcatcat caaggtgttg   2580

gctcagattt attcttaatt ggatgtttaa agcatgtact accttgttac agttggttta   2640

gtgtagtgga ttattgacat gacatcatga gaagatgtgt aattttatac cacatttata   2700

aaacatgatt ttgttttcta cccttcaagg taaacattaa aaataaggtg gtacttgtgt   2760

acttgtacat aaaaccaaaa ttatagttgg gaaaaaaata aatttatata tgaaaatgtc   2820

aaaatcattt taaaagtatt attttcaaat aaaatggaga agctggtgaa aagtcatatt   2880

ggcaattttt atgtagttta agtggaatta agcagaggga gatgcttttg ggtttttaat   2940

atgccacttc tgagtgaaaa catctcgtgg agtcattgtg ttcagctct               2989


<210>  8506
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  8506

Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Thr Asn Thr Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Thr Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp Val Lys Glu Cys Met 
                85                  90                  95      


Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu Thr Ser Ile Lys Asp 
            100                 105                 110         


His Gln Trp His Ile Gln Ala Cys Cys Ala Leu Thr Gly Glu Gly Leu 
        115                 120                 125             


Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu Lys Ile Arg 
    130                 135                 140         


<210>  8507
<211>  3269
<212>  DNA
<213>  Homosapiens

<400>  8507
cccgcccgcg tggtcgtcgc caccgcagcc gcccgagagg agctggggga ggacggtggc     60

ccgcgaggct cgtcgcagac aacgcggcgg cgatgtccgc gagccaggcg agtgccgcgg    120

cggcagcggc ggggccttgc gcgcggcagg gcggcctggg cttcggcctc cctccggttc    180

cctggaagcg ggcccgcgac cagcgcggga gcagcagcag aggcggaggc tccagcgcgt    240

ctctctcctc cccctcagcc tgagccgggg gaagccaggc ggcccgggtg tctggagggg    300

gggggtccgc tgcccgagaa tgggaattct cttcactaga atatggagac tgttcaatca    360

ccaggagcac aaagttatca ttgttgggct ggataatgca gggaaaacta ccattcttta    420

ccaattttct atgaatgaag ttgtacatac atctcctaca ataggaagta atgtagaaga    480

gatagtgatt aataatacac gtttcctaat gtgggatatt ggtggccaag aatctcttcg    540

ttcttcctgg aacacttact atactaacac agagtttgta atagttgttg tggacagtac    600

agacagagag aggatttctg taactagaga agaactctat aaaatgttag cgcatgagga    660

cctaagaaaa gctggattgc tgatttttgc taataaacaa gatgttaaag aatgcatgac    720

tgtagcagaa atctcccagt ttttgaagct aacttctatt aaagatcacc agtggcatat    780

ccaggcatgc tgtgctctaa ctggcgaggg attgtgccaa ggacttgaat ggatgatgtc    840

acgacttaag attagatgat ctctactgac ctcttctcat agattttgta taaatgaagt    900

gctggacttt acctgaaagc tgcaaaaatt aatggtttag atatatttat aataaactga    960

tttaaacttt ttctataaga agaaaaatta agaccactta tttgaaaaca aagatgaagt   1020

ctcaccttcc agtttgcttt ctcattagtt ttttccaaag taagttattg aagctgtgat   1080

tgacattttt ctcataatga atcctctcag gacattgtgt agcctatggt aagtacaaag   1140

ggagaggaag acattttgaa ttttaagagc tttattatca gtttaaccct ccctagttga   1200

atgttatttt cttcttgttc cattaagtca gaatacaaat cagcacagat attcgaatgt   1260

ttccaatatt ttaaaatgta atgttactta tgaaaagtat tttgcttaag gttgtgtgtg   1320

tattgtgtat atacctcaag ttcaagttaa tggcattgat ttatgttcca gacaaaaata   1380

acacaaataa taatatcctt cgttataacc acaatgagat aagtattggc attagtgttc   1440

agtgccattt tatactttct ctctgtgttc tctgtattgt actaaccaac ctcccaaatc   1500

gctgagctgc ttgtttaaaa aaaaaaaaaa ggaaaaggaa aaagcatgac attgtgtatc   1560

gattttttgt tgttgaccaa aatcacacac atggaaacat gtaattcaac agagtgggaa   1620

agctagcaga ttcttggctt agtattacta ataggcagga ttgtacaatg agcaactatc   1680

agattattcc tttcagtggt tcttatggca tctaaattac tgaataaatt attaatccat   1740

taatcagtga atcaaattat gattacaatt atcaaatgaa tgctcagcat taattgaaaa   1800

ctgttttgtg aaacatgtct acccagaaaa gtagcattct ataaatacta ttaaacaact   1860

tagctatatt atttttaagt attaaattat atgtcaagca gttaaagtga atttcagagt   1920

aaaagtaagg catgtttctg agcaacattg ataatttctt aatttgcaaa tttcttctta   1980

ttttggtact tggaatatag tgtgagattt tttatttcta aattttgttg tatcttctat   2040

tacataaatg cattgacaat tataaaatgc aagtgttttt tgaatgattt taagaatttg   2100

gcttaaaaat tgattgatac aacgtattat ttgtactaag aagtaacttg acccaaaaca   2160

ccttttatgt ttgcttaggg tatatttttt cagtgtctga aagtcaaagg tattcctgtc   2220

acaactgtaa acaaacttat cctaaatgtg ttaaaacata ttcttgggta ctctatttat   2280

gtatctttca tgccttgaaa atctgaaggt taatccaaac tcacatgttt tagcatattt   2340

gagaaaaaaa aactaccttc aatatcagcc ttttaaattt catgaagatt ttggtgagga   2400

ataatagtat atagtttaag tattgacaaa actttgaaag tttctttctt taaaatggga   2460

aatactcaat atctaaatcc aggtcaggca tgggatatca gtatttaaca ttggatgttt   2520

tatgttttat atttataatg ttcaaaatgc aagcataaca tttaatattt gtccacatgg   2580

ttttacaaaa gtaaatctta aattactaag cttttcccat atgttctcgt actttctcaa   2640

atccctataa agaattactt gttatctatt aaaaatctcc tttacccaaa tctgtattat   2700

ggtttcgcca gacaaatatt atgtgatgta gcccagaaaa tccacacctt ttgtcctttt   2760

tatgttttaa tttgaataat catgtgctta gtcccttgga ttactgccac atcagtttaa   2820

cacgatatca gcacattccc ttgtcatcat caaggtgttg gctcagattt attcttaatt   2880

ggatgtttaa agcatgtact accttgttac agttggttta gtgtagtgga ttattgacat   2940

gacatcatga gaagatgtgt aattttatac cacatttata aaacatgatt ttgttttcta   3000

cccttcaagg taaacattaa aaataaggtg gtacttgtgt acttgtacat aaaaccaaaa   3060

ttatagttgg gaaaaaaata aatttatata tgaaaatgtc aaaatcattt taaaagtatt   3120

attttcaaat aaaatggaga agctggtgaa aagtcatatt ggcaattttt atgtagttta   3180

agtggaatta agcagaggga gatgcttttg ggtttttaat atgccacttc tgagtgaaaa   3240

catctcgtgg agtcattgtg ttcagctct                                     3269


<210>  8508
<211>  179
<212>  PRT
<213>  Homosapiens

<400>  8508

Met Gly Ile Leu Phe Thr Arg Ile Trp Arg Leu Phe Asn His Gln Glu 
1               5                   10                  15      


His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile 
            20                  25                  30          


Leu Tyr Gln Phe Ser Met Asn Glu Val Val His Thr Ser Pro Thr Ile 
        35                  40                  45              


Gly Ser Asn Val Glu Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met 
    50                  55                  60                  


Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr 
65                  70                  75                  80  


Tyr Thr Asn Thr Glu Phe Val Ile Val Val Val Asp Ser Thr Asp Arg 
                85                  90                  95      


Glu Arg Ile Ser Val Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His 
            100                 105                 110         


Glu Asp Leu Arg Lys Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Val Lys Glu Cys Met Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu 
    130                 135                 140                 


Thr Ser Ile Lys Asp His Gln Trp His Ile Gln Ala Cys Cys Ala Leu 
145                 150                 155                 160 


Thr Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu 
                165                 170                 175     


Lys Ile Arg 
            


<210>  8509
<211>  2629
<212>  DNA
<213>  Homosapiens

<400>  8509
ggagctgggg gaggacggtg gcccgcgagg ctcgtcgcag acaacgcggc ggcgatgtcc     60

gcgagccaga gcacaaagtt atcattgttg ggctggataa tgcagggaaa actaccattc    120

tttaccaatt ttctatgaat gaagttgtac atacatctcc tacaatagga agtaatgtag    180

aagagatagt gattaataat acacgtttcc taatgtggga tattggtggc caagaatctc    240

ttcgttcttc ctggaacact tactatacta acacagagtt tgtaatagtt gttgtggaca    300

gtacagacag agagaggatt tctgtaacta gagaagaact ctataaaatg ttagcgcatg    360

aggacctaag aaaagctgga ttgctgattt ttgctaataa acaagatgtt aaagaatgca    420

tgactgtagc agaaatctcc cagtttttga agaccactta tttgaaaaca aagatgaagt    480

ctcaccttcc agtttgcttt ctcattagtt ttttccaaag taagttattg aagctgtgat    540

tgacattttt ctcataatga atcctctcag gacattgtgt agcctatggt aagtacaaag    600

ggagaggaag acattttgaa ttttaagagc tttattatca gtttaaccct ccctagttga    660

atgttatttt cttcttgttc cattaagtca gaatacaaat cagcacagat attcgaatgt    720

ttccaatatt ttaaaatgta atgttactta tgaaaagtat tttgcttaag gttgtgtgtg    780

tattgtgtat atacctcaag ttcaagttaa tggcattgat ttatgttcca gacaaaaata    840

acacaaataa taatatcctt cgttataacc acaatgagat aagtattggc attagtgttc    900

agtgccattt tatactttct ctctgtgttc tctgtattgt actaaccaac ctcccaaatc    960

gctgagctgc ttgtttaaaa aaaaaaaaaa ggaaaaggaa aaagcatgac attgtgtatc   1020

gattttttgt tgttgaccaa aatcacacac atggaaacat gtaattcaac agagtgggaa   1080

agctagcaga ttcttggctt agtattacta ataggcagga ttgtacaatg agcaactatc   1140

agattattcc tttcagtggt tcttatggca tctaaattac tgaataaatt attaatccat   1200

taatcagtga atcaaattat gattacaatt atcaaatgaa tgctcagcat taattgaaaa   1260

ctgttttgtg aaacatgtct acccagaaaa gtagcattct ataaatacta ttaaacaact   1320

tagctatatt atttttaagt attaaattat atgtcaagca gttaaagtga atttcagagt   1380

aaaagtaagg catgtttctg agcaacattg ataatttctt aatttgcaaa tttcttctta   1440

ttttggtact tggaatatag tgtgagattt tttatttcta aattttgttg tatcttctat   1500

tacataaatg cattgacaat tataaaatgc aagtgttttt tgaatgattt taagaatttg   1560

gcttaaaaat tgattgatac aacgtattat ttgtactaag aagtaacttg acccaaaaca   1620

ccttttatgt ttgcttaggg tatatttttt cagtgtctga aagtcaaagg tattcctgtc   1680

acaactgtaa acaaacttat cctaaatgtg ttaaaacata ttcttgggta ctctatttat   1740

gtatctttca tgccttgaaa atctgaaggt taatccaaac tcacatgttt tagcatattt   1800

gagaaaaaaa aactaccttc aatatcagcc ttttaaattt catgaagatt ttggtgagga   1860

ataatagtat atagtttaag tattgacaaa actttgaaag tttctttctt taaaatggga   1920

aatactcaat atctaaatcc aggtcaggca tgggatatca gtatttaaca ttggatgttt   1980

tatgttttat atttataatg ttcaaaatgc aagcataaca tttaatattt gtccacatgg   2040

ttttacaaaa gtaaatctta aattactaag cttttcccat atgttctcgt actttctcaa   2100

atccctataa agaattactt gttatctatt aaaaatctcc tttacccaaa tctgtattat   2160

ggtttcgcca gacaaatatt atgtgatgta gcccagaaaa tccacacctt ttgtcctttt   2220

tatgttttaa tttgaataat catgtgctta gtcccttgga ttactgccac atcagtttaa   2280

cacgatatca gcacattccc ttgtcatcat caaggtgttg gctcagattt attcttaatt   2340

ggatgtttaa agcatgtact accttgttac agttggttta gtgtagtgga ttattgacat   2400

gacatcatga gaagatgtgt aattttatac cacatttata aaacatgatt ttgttttcta   2460

cccttcaagg taaacattaa aaataaggtg gtacttgtgt acttgtacat aaaaccaaaa   2520

ttatagttgg gaaaaaaata aatttatata tgaaaatgtc aaaatcattt taaaagtatt   2580

attttcaaat aaaatggaga agctggtgaa aagtcatatt ggcaatttt               2629


<210>  8510
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  8510

Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Thr Asn Thr Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Thr Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp Val Lys Glu Cys Met 
                85                  90                  95      


Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Thr Thr Tyr Leu Lys Thr 
            100                 105                 110         


Lys Met Lys Ser His Leu Pro Val Cys Phe Leu Ile Ser Phe Phe Gln 
        115                 120                 125             


Ser Lys Leu Leu Lys Leu 
    130                 


<210>  8511
<211>  2889
<212>  DNA
<213>  Homosapiens

<400>  8511
ccgcagccgc ccgagaggag ctgggggagg acggtggccc gcgaggctcg tcgcagacaa     60

cgcggcggcg atgtccgcga gccagagcac aaagttatca ttgttgggct ggataatgca    120

gggaaaacta ccattcttta ccaattttct atgaatgaag ttgtacatac atctcctaca    180

ataggaagta atgtagaaga gatagtgatt aataatacac gtttcctaat gtgggatatt    240

ggtggccaag aatctcttcg ttcttcctgg aacacttact atactaacac agagtttgta    300

atagttgttg tggacagtac agacagagag aggatttctg taactagaga agaactctat    360

aaaatgttag cgcatgagga cctaagaaaa gctggattgc tgatttttgc taataaacaa    420

gatgttaaag aatgcatgac tgtagcagaa atctcccagt ttttgaagct aacttctatt    480

aaagatcacc agtggcatat ccaggcatgc tgtgctctaa ctggcgaggg attgtgccaa    540

ggacttgaat ggatgatgtc acgacttaag attagatgat ctctactgac ctcttctcat    600

agattttgta taaatgaagt gctggacttt acctgaaagc tgcaaaaatt aatggtttag    660

atatatttat aataaactga tttaaacttt ttctataaga agaaaaatta agaccactta    720

tttgaaaaca aagatgaagt ctcaccttcc agtttgcttt ctcattagtt ttttccaaag    780

taagttattg aagctgtgat tgacattttt ctcataatga atcctctcag gacattgtgt    840

agcctatggt aagtacaaag ggagaggaag acattttgaa ttttaagagc tttattatca    900

gtttaaccct ccctagttga atgttatttt cttcttgttc cattaagtca gaatacaaat    960

cagcacagat attcgaatgt ttccaatatt ttaaaatgta atgttactta tgaaaagtat   1020

tttgcttaag gttgtgtgtg tattgtgtat atacctcaag ttcaagttaa tggcattgat   1080

ttatgttcca gacaaaaata acacaaataa taatatcctt cgttataacc acaatgagat   1140

aagtattggc attagtgttc agtgccattt tatactttct ctctgtgttc tctgtattgt   1200

actaaccaac ctcccaaatc gctgagctgc ttgtttaaaa aaaaaaaaaa ggaaaaggaa   1260

aaagcatgac attgtgtatc gattttttgt tgttgaccaa aatcacacac atggaaacat   1320

gtaattcaac agagtgggaa agctagcaga ttcttggctt agtattacta ataggcagga   1380

ttgtacaatg agcaactatc agattattcc tttcagtggt tcttatggca tctaaattac   1440

tgaataaatt attaatccat taatcagtga atcaaattat gattacaatt atcaaatgaa   1500

tgctcagcat taattgaaaa ctgttttgtg aaacatgtct acccagaaaa gtagcattct   1560

ataaatacta ttaaacaact tagctatatt atttttaagt attaaattat atgtcaagca   1620

gttaaagtga atttcagagt aaaagtaagg catgtttctg agcaacattg ataatttctt   1680

aatttgcaaa tttcttctta ttttggtact tggaatatag tgtgagattt tttatttcta   1740

aattttgttg tatcttctat tacataaatg cattgacaat tataaaatgc aagtgttttt   1800

tgaatgattt taagaatttg gcttaaaaat tgattgatac aacgtattat ttgtactaag   1860

aagtaacttg acccaaaaca ccttttatgt ttgcttaggg tatatttttt cagtgtctga   1920

aagtcaaagg tattcctgtc acaactgtaa acaaacttat cctaaatgtg ttaaaacata   1980

ttcttgggta ctctatttat gtatctttca tgccttgaaa atctgaaggt taatccaaac   2040

tcacatgttt tagcatattt gagaaaaaaa aactaccttc aatatcagcc ttttaaattt   2100

catgaagatt ttggtgagga ataatagtat atagtttaag tattgacaaa actttgaaag   2160

tttctttctt taaaatggga aatactcaat atctaaatcc aggtcaggca tgggatatca   2220

gtatttaaca ttggatgttt tatgttttat atttataatg ttcaaaatgc aagcataaca   2280

tttaatattt gtccacatgg ttttacaaaa gtaaatctta aattactaag cttttcccat   2340

atgttctcgt actttctcaa atccctataa agaattactt gttatctatt aaaaatctcc   2400

tttacccaaa tctgtattat ggtttcgcca gacaaatatt atgtgatgta gcccagaaaa   2460

tccacacctt ttgtcctttt tatgttttaa tttgaataat catgtgctta gtcccttgga   2520

ttactgccac atcagtttaa cacgatatca gcacattccc ttgtcatcat caaggtgttg   2580

gctcagattt attcttaatt ggatgtttaa agcatgtact accttgttac agttggttta   2640

gtgtagtgga ttattgacat gacatcatga gaagatgtgt aattttatac cacatttata   2700

aaacatgatt ttgttttcta cccttcaagg taaacattaa aaataaggtg gtacttgtgt   2760

acttgtacat aaaaccaaaa ttatagttgg gaaaaaaata aatttatata tgaaaatgtc   2820

aaaatcattt taaaagtatt attttcaaat aaaatggaga agctggtgaa aagtcatatt   2880

ggcaatttt                                                           2889


<210>  8512
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  8512

Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Thr Asn Thr Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Thr Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp Val Lys Glu Cys Met 
                85                  90                  95      


Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu Thr Ser Ile Lys Asp 
            100                 105                 110         


His Gln Trp His Ile Gln Ala Cys Cys Ala Leu Thr Gly Glu Gly Leu 
        115                 120                 125             


Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu Lys Ile Arg 
    130                 135                 140         


<210>  8513
<211>  3169
<212>  DNA
<213>  Homosapiens

<400>  8513
cccgcccgcg tggtcgtcgc caccgcagcc gcccgagagg agctggggga ggacggtggc     60

ccgcgaggct cgtcgcagac aacgcggcgg cgatgtccgc gagccaggcg agtgccgcgg    120

cggcagcggc ggggccttgc gcgcggcagg gcggcctggg cttcggcctc cctccggttc    180

cctggaagcg ggcccgcgac cagcgcggga gcagcagcag aggcggaggc tccagcgcgt    240

ctctctcctc cccctcagcc tgagccgggg gaagccaggc ggcccgggtg tctggagggg    300

gggggtccgc tgcccgagaa tgggaattct cttcactaga atatggagac tgttcaatca    360

ccaggagcac aaagttatca ttgttgggct ggataatgca gggaaaacta ccattcttta    420

ccaattttct atgaatgaag ttgtacatac atctcctaca ataggaagta atgtagaaga    480

gatagtgatt aataatacac gtttcctaat gtgggatatt ggtggccaag aatctcttcg    540

ttcttcctgg aacacttact atactaacac agagtttgta atagttgttg tggacagtac    600

agacagagag aggatttctg taactagaga agaactctat aaaatgttag cgcatgagga    660

cctaagaaaa gctggattgc tgatttttgc taataaacaa gatgttaaag aatgcatgac    720

tgtagcagaa atctcccagt ttttgaagct aacttctatt aaagatcacc agtggcatat    780

ccaggcatgc tgtgctctaa ctggcgaggg attgtgccaa ggacttgaat ggatgatgtc    840

acgacttaag attagatgat ctctactgac ctcttctcat agattttgta taaatgaagt    900

gctggacttt acctgaaagc tgcaaaaatt aatggtttag atatatttat aataaactga    960

tttaaacttt ttctataaga agaaaaatta agaccactta tttgaaaaca aagatgaagt   1020

ctcaccttcc agtttgcttt ctcattagtt ttttccaaag taagttattg aagctgtgat   1080

tgacattttt ctcataatga atcctctcag gacattgtgt agcctatggt aagtacaaag   1140

ggagaggaag acattttgaa ttttaagagc tttattatca gtttaaccct ccctagttga   1200

atgttatttt cttcttgttc cattaagtca gaatacaaat cagcacagat attcgaatgt   1260

ttccaatatt ttaaaatgta atgttactta tgaaaagtat tttgcttaag gttgtgtgtg   1320

tattgtgtat atacctcaag ttcaagttaa tggcattgat ttatgttcca gacaaaaata   1380

acacaaataa taatatcctt cgttataacc acaatgagat aagtattggc attagtgttc   1440

agtgccattt tatactttct ctctgtgttc tctgtattgt actaaccaac ctcccaaatc   1500

gctgagctgc ttgtttaaaa aaaaaaaaaa ggaaaaggaa aaagcatgac attgtgtatc   1560

gattttttgt tgttgaccaa aatcacacac atggaaacat gtaattcaac agagtgggaa   1620

agctagcaga ttcttggctt agtattacta ataggcagga ttgtacaatg agcaactatc   1680

agattattcc tttcagtggt tcttatggca tctaaattac tgaataaatt attaatccat   1740

taatcagtga atcaaattat gattacaatt atcaaatgaa tgctcagcat taattgaaaa   1800

ctgttttgtg aaacatgtct acccagaaaa gtagcattct ataaatacta ttaaacaact   1860

tagctatatt atttttaagt attaaattat atgtcaagca gttaaagtga atttcagagt   1920

aaaagtaagg catgtttctg agcaacattg ataatttctt aatttgcaaa tttcttctta   1980

ttttggtact tggaatatag tgtgagattt tttatttcta aattttgttg tatcttctat   2040

tacataaatg cattgacaat tataaaatgc aagtgttttt tgaatgattt taagaatttg   2100

gcttaaaaat tgattgatac aacgtattat ttgtactaag aagtaacttg acccaaaaca   2160

ccttttatgt ttgcttaggg tatatttttt cagtgtctga aagtcaaagg tattcctgtc   2220

acaactgtaa acaaacttat cctaaatgtg ttaaaacata ttcttgggta ctctatttat   2280

gtatctttca tgccttgaaa atctgaaggt taatccaaac tcacatgttt tagcatattt   2340

gagaaaaaaa aactaccttc aatatcagcc ttttaaattt catgaagatt ttggtgagga   2400

ataatagtat atagtttaag tattgacaaa actttgaaag tttctttctt taaaatggga   2460

aatactcaat atctaaatcc aggtcaggca tgggatatca gtatttaaca ttggatgttt   2520

tatgttttat atttataatg ttcaaaatgc aagcataaca tttaatattt gtccacatgg   2580

ttttacaaaa gtaaatctta aattactaag cttttcccat atgttctcgt actttctcaa   2640

atccctataa agaattactt gttatctatt aaaaatctcc tttacccaaa tctgtattat   2700

ggtttcgcca gacaaatatt atgtgatgta gcccagaaaa tccacacctt ttgtcctttt   2760

tatgttttaa tttgaataat catgtgctta gtcccttgga ttactgccac atcagtttaa   2820

cacgatatca gcacattccc ttgtcatcat caaggtgttg gctcagattt attcttaatt   2880

ggatgtttaa agcatgtact accttgttac agttggttta gtgtagtgga ttattgacat   2940

gacatcatga gaagatgtgt aattttatac cacatttata aaacatgatt ttgttttcta   3000

cccttcaagg taaacattaa aaataaggtg gtacttgtgt acttgtacat aaaaccaaaa   3060

ttatagttgg gaaaaaaata aatttatata tgaaaatgtc aaaatcattt taaaagtatt   3120

attttcaaat aaaatggaga agctggtgaa aagtcatatt ggcaatttt               3169


<210>  8514
<211>  179
<212>  PRT
<213>  Homosapiens

<400>  8514

Met Gly Ile Leu Phe Thr Arg Ile Trp Arg Leu Phe Asn His Gln Glu 
1               5                   10                  15      


His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile 
            20                  25                  30          


Leu Tyr Gln Phe Ser Met Asn Glu Val Val His Thr Ser Pro Thr Ile 
        35                  40                  45              


Gly Ser Asn Val Glu Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met 
    50                  55                  60                  


Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr 
65                  70                  75                  80  


Tyr Thr Asn Thr Glu Phe Val Ile Val Val Val Asp Ser Thr Asp Arg 
                85                  90                  95      


Glu Arg Ile Ser Val Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His 
            100                 105                 110         


Glu Asp Leu Arg Lys Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Val Lys Glu Cys Met Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu 
    130                 135                 140                 


Thr Ser Ile Lys Asp His Gln Trp His Ile Gln Ala Cys Cys Ala Leu 
145                 150                 155                 160 


Thr Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu 
                165                 170                 175     


Lys Ile Arg 
            


<210>  8515
<211>  1008
<212>  DNA
<213>  Homosapiens

<400>  8515
ggagctgggg gaggacggtg gcccgcgagg ctcgtcgcag acaacgcggc ggcgatgtcc     60

gcgagccaga gcacaaagtt atcattgttg ggctggataa tgcagggaaa actaccattc    120

tttaccaatt ttctatgaat gaagttgtac atacatctcc tacaatagga agtaatgtag    180

aagagatagt gattaataat acacgtttcc taatgtggga tattggtggc caagaatctc    240

ttcgttcttc ctggaacact tactatacta acacagagtt tgtaatagtt gttgtggaca    300

gtacagacag agagaggatt tctgtaacta gagaagaact ctataaaatg ttagcgcatg    360

aggacctaag aaaagctgga ttgctgattt ttgctaataa acaagatgtt aaagaatgca    420

tgactgtagc agaaatctcc cagtttttga agaccactta tttgaaaaca aagatgaagt    480

ctcaccttcc agtttgcttt ctcattagtt ttttccaaag taagttattg aagctgtgat    540

tgacattttt ctcataatga atcctctcag gacattgtgt agcctatggt aagtacaaag    600

ggagaggaag acattttgaa ttttaagagc tttattatca gtttaaccct ccctagttga    660

atgttatttt cttcttgttc cattaagtca gaatacaaat cagcacagat attcgaatgt    720

ttccaatatt ttaaaatgta atgttactta tgaaaagtat tttgcttaag gttgtgtgtg    780

tattgtgtat atacctcaag ttcaagttaa tggcattgat ttatgttcca gacaaaaata    840

acacaaataa taatatcctt cgttataacc acaatgagat aagtattggc attagtgttc    900

agtgccattt tatactttct ctctgtgttc tctgtattgt actaaccaac ctcccaaatc    960

gctgagctgc ttgtttaaaa aaaaaaaaaa ggaaaaggaa aaagcatg                1008


<210>  8516
<211>  134
<212>  PRT
<213>  Homosapiens

<400>  8516

Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Thr Asn Thr Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Thr Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp Val Lys Glu Cys Met 
                85                  90                  95      


Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Thr Thr Tyr Leu Lys Thr 
            100                 105                 110         


Lys Met Lys Ser His Leu Pro Val Cys Phe Leu Ile Ser Phe Phe Gln 
        115                 120                 125             


Ser Lys Leu Leu Lys Leu 
    130                 


<210>  8517
<211>  1276
<212>  DNA
<213>  Homosapiens

<400>  8517
cgtcgccacc gcagccgccc gagaggagct gggggaggac ggtggcccgc gaggctcgtc     60

gcagacaacg cggcggcgat gtccgcgagc cagagcacaa agttatcatt gttgggctgg    120

ataatgcagg gaaaactacc attctttacc aattttctat gaatgaagtt gtacatacat    180

ctcctacaat aggaagtaat gtagaagaga tagtgattaa taatacacgt ttcctaatgt    240

gggatattgg tggccaagaa tctcttcgtt cttcctggaa cacttactat actaacacag    300

agtttgtaat agttgttgtg gacagtacag acagagagag gatttctgta actagagaag    360

aactctataa aatgttagcg catgaggacc taagaaaagc tggattgctg atttttgcta    420

ataaacaaga tgttaaagaa tgcatgactg tagcagaaat ctcccagttt ttgaagctaa    480

cttctattaa agatcaccag tggcatatcc aggcatgctg tgctctaact ggcgagggat    540

tgtgccaagg acttgaatgg atgatgtcac gacttaagat tagatgatct ctactgacct    600

cttctcatag attttgtata aatgaagtgc tggactttac ctgaaagctg caaaaattaa    660

tggtttagat atatttataa taaactgatt taaacttttt ctataagaag aaaaattaag    720

accacttatt tgaaaacaaa gatgaagtct caccttccag tttgctttct cattagtttt    780

ttccaaagta agttattgaa gctgtgattg acatttttct cataatgaat cctctcagga    840

cattgtgtag cctatggtaa gtacaaaggg agaggaagac attttgaatt ttaagagctt    900

tattatcagt ttaaccctcc ctagttgaat gttattttct tcttgttcca ttaagtcaga    960

atacaaatca gcacagatat tcgaatgttt ccaatatttt aaaatgtaat gttacttatg   1020

aaaagtattt tgcttaaggt tgtgtgtgta ttgtgtatat acctcaagtt caagttaatg   1080

gcattgattt atgttccaga caaaaataac acaaataata atatccttcg ttataaccac   1140

aatgagataa gtattggcat tagtgttcag tgccatttta tactttctct ctgtgttctc   1200

tgtattgtac taaccaacct cccaaatcgc tgagctgctt gtttaaaaaa aaaaaaaagg   1260

aaaaggaaaa agcatg                                                   1276


<210>  8518
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  8518

Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Thr Asn Thr Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Thr Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp Val Lys Glu Cys Met 
                85                  90                  95      


Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu Thr Ser Ile Lys Asp 
            100                 105                 110         


His Gln Trp His Ile Gln Ala Cys Cys Ala Leu Thr Gly Glu Gly Leu 
        115                 120                 125             


Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu Lys Ile Arg 
    130                 135                 140         


<210>  8519
<211>  1548
<212>  DNA
<213>  Homosapiens

<400>  8519
cccgcccgcg tggtcgtcgc caccgcagcc gcccgagagg agctggggga ggacggtggc     60

ccgcgaggct cgtcgcagac aacgcggcgg cgatgtccgc gagccaggcg agtgccgcgg    120

cggcagcggc ggggccttgc gcgcggcagg gcggcctggg cttcggcctc cctccggttc    180

cctggaagcg ggcccgcgac cagcgcggga gcagcagcag aggcggaggc tccagcgcgt    240

ctctctcctc cccctcagcc tgagccgggg gaagccaggc ggcccgggtg tctggagggg    300

gggggtccgc tgcccgagaa tgggaattct cttcactaga atatggagac tgttcaatca    360

ccaggagcac aaagttatca ttgttgggct ggataatgca gggaaaacta ccattcttta    420

ccaattttct atgaatgaag ttgtacatac atctcctaca ataggaagta atgtagaaga    480

gatagtgatt aataatacac gtttcctaat gtgggatatt ggtggccaag aatctcttcg    540

ttcttcctgg aacacttact atactaacac agagtttgta atagttgttg tggacagtac    600

agacagagag aggatttctg taactagaga agaactctat aaaatgttag cgcatgagga    660

cctaagaaaa gctggattgc tgatttttgc taataaacaa gatgttaaag aatgcatgac    720

tgtagcagaa atctcccagt ttttgaagct aacttctatt aaagatcacc agtggcatat    780

ccaggcatgc tgtgctctaa ctggcgaggg attgtgccaa ggacttgaat ggatgatgtc    840

acgacttaag attagatgat ctctactgac ctcttctcat agattttgta taaatgaagt    900

gctggacttt acctgaaagc tgcaaaaatt aatggtttag atatatttat aataaactga    960

tttaaacttt ttctataaga agaaaaatta agaccactta tttgaaaaca aagatgaagt   1020

ctcaccttcc agtttgcttt ctcattagtt ttttccaaag taagttattg aagctgtgat   1080

tgacattttt ctcataatga atcctctcag gacattgtgt agcctatggt aagtacaaag   1140

ggagaggaag acattttgaa ttttaagagc tttattatca gtttaaccct ccctagttga   1200

atgttatttt cttcttgttc cattaagtca gaatacaaat cagcacagat attcgaatgt   1260

ttccaatatt ttaaaatgta atgttactta tgaaaagtat tttgcttaag gttgtgtgtg   1320

tattgtgtat atacctcaag ttcaagttaa tggcattgat ttatgttcca gacaaaaata   1380

acacaaataa taatatcctt cgttataacc acaatgagat aagtattggc attagtgttc   1440

agtgccattt tatactttct ctctgtgttc tctgtattgt actaaccaac ctcccaaatc   1500

gctgagctgc ttgtttaaaa aaaaaaaaaa ggaaaaggaa aaagcatg                1548


<210>  8520
<211>  179
<212>  PRT
<213>  Homosapiens

<400>  8520

Met Gly Ile Leu Phe Thr Arg Ile Trp Arg Leu Phe Asn His Gln Glu 
1               5                   10                  15      


His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile 
            20                  25                  30          


Leu Tyr Gln Phe Ser Met Asn Glu Val Val His Thr Ser Pro Thr Ile 
        35                  40                  45              


Gly Ser Asn Val Glu Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met 
    50                  55                  60                  


Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr 
65                  70                  75                  80  


Tyr Thr Asn Thr Glu Phe Val Ile Val Val Val Asp Ser Thr Asp Arg 
                85                  90                  95      


Glu Arg Ile Ser Val Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His 
            100                 105                 110         


Glu Asp Leu Arg Lys Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Val Lys Glu Cys Met Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu 
    130                 135                 140                 


Thr Ser Ile Lys Asp His Gln Trp His Ile Gln Ala Cys Cys Ala Leu 
145                 150                 155                 160 


Thr Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu 
                165                 170                 175     


Lys Ile Arg 
            


<210>  8521
<211>  738
<212>  DNA
<213>  Homosapiens

<400>  8521
cccgcccgcg tggtcgtcgc caccgcagcc gcccgagagg agctggggga ggacggtggc     60

ccgcgaggct cgtcgcagac aacgcggcgg cgatgtccgc gagccaggcg agtgccgcgg    120

cggcagcggc ggggccttgc gcgcggcagg gcggcctggg cttcggcctc cctccggttc    180

cctggaagcg ggcccgcgac cagcgcggga gcagcagcag aggcggaggc tccagcgcgt    240

ctctctcctc cccctcagcc tgagccgggg gaagccaggc ggcccgggtg tctggagggg    300

gggggtccgc tgcccgagaa tgggaattct cttcactaga atatggagac tgttcaatca    360

ccaggagcac aaagttatca ttgttgggct ggataatgca gggaaaacta ccattcttta    420

ccaattttct atgaatgaag ttgtacatac atctcctaca ataggaagta atgtagaaga    480

gatagtgatt aataatacac gtttcctaat gtgggatatt ggtggccaag aatctcttcg    540

ttcttcctgg aacacttact atactaacac agagtttgta atagttgttg tggacagtac    600

agacagagag aggatttctg taactagaga agaactctat aaaatgttag cgcatgagga    660

cctaagaaaa gctggattgc tgatttttgc taataaacaa gatgttaaag aatgcatgac    720

tgtagcagaa atctccca                                                  738


<210>  8522
<211>  138
<212>  PRT
<213>  Homosapiens

<400>  8522

Met Gly Ile Leu Phe Thr Arg Ile Trp Arg Leu Phe Asn His Gln Glu 
1               5                   10                  15      


His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile 
            20                  25                  30          


Leu Tyr Gln Phe Ser Met Asn Glu Val Val His Thr Ser Pro Thr Ile 
        35                  40                  45              


Gly Ser Asn Val Glu Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met 
    50                  55                  60                  


Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr 
65                  70                  75                  80  


Tyr Thr Asn Thr Glu Phe Val Ile Val Val Val Asp Ser Thr Asp Arg 
                85                  90                  95      


Glu Arg Ile Ser Val Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His 
            100                 105                 110         


Glu Asp Leu Arg Lys Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Val Lys Glu Cys Met Thr Val Ala Glu Ile 
    130                 135             


<210>  8523
<211>  582
<212>  DNA
<213>  Homosapiens

<400>  8523
gcccgcgtgg tcgtcgccac cgcagccgcc cgagaggagc tgggggagga cggtggcccg     60

cgaggctcgt cgcagacaac gcggcggcga tgtccgcgag ccagagcaca aagttatcat    120

tgttgggctg gataatgcag ggaaaactac cattctttac caattttcta tgaatgaagt    180

tgtacataca tctcctacaa taggaagtaa tgtagaagag atagtgatta ataatacacg    240

tttcctaatg tgggatattg gtggccaaga atctcttcgt tcttcctgga acacttacta    300

tactaacaca gagtttgtaa tagttgttgt ggacagtaca gacagagaga ggatttctgt    360

aactagagaa gaactctata aaatgttagc gcatgagaag taaaaagaag acctaagtag    420

ggcctagttg gaaagtgaaa ggagactgaa tgaggagatg accagagaag aaaggaatta    480

cagatgaagt tgggagtttg agcaaggtac tcagtagggt caagaagagc caaacaggca    540

aaattctgca gagagacaaa tggatcaaag agtgagaatg tg                       582


<210>  8524
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  8524

Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Thr Asn Thr Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Thr Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Lys 
65                  70                  75          


<210>  8525
<211>  620
<212>  DNA
<213>  Homosapiens

<400>  8525
aggctcgtcg cagacaacgc ggcggcgatg tccgcgagcc aggcgagtgc cgcggcggca     60

gcggcggggc cttgcgcgcg gcagggcggc ctgggcttcg gcctccctcc ggttccctgg    120

aagcgggccc gcgaccagcg cgggagcagc agcagaggcg gaggctccag cgcgtctctc    180

tcctccccct cagcctgagc cgggggaagc caggcggccc gggtgtctgg aggggggggg    240

tccgctgccc gagaatggga attctcttca ctagaatatg gagactgttc aatcaccagg    300

ccctttcttt gctcaccagt tgtgtttgga caccacatag aagtgctggg gtcttctgga    360

atgaaggtta tagattgctg ccctaaccgc accactgagc gaccgagggt tgcagaatgc    420

ggaaaacggg aggaatcgct cgacttgtcc attacacctc tggtttatga gcctgccctc    480

cactgccacc cgtctttgtg tgtgttgggg gcaggggggg ttcttctgcc tcctgaatag    540

agatggactt ctctccattt gttttactta ttatatctgt gtttaaggtt aagcttaagg    600

tcatttttct actcgtgtgg                                                620


<210>  8526
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  8526

Met Gly Ile Leu Phe Thr Arg Ile Trp Arg Leu Phe Asn His Gln Ala 
1               5                   10                  15      


Leu Ser Leu Leu Thr Ser Cys Val Trp Thr Pro His Arg Ser Ala Gly 
            20                  25                  30          


Val Phe Trp Asn Glu Gly Tyr Arg Leu Leu Pro 
        35                  40              


<210>  8527
<211>  582
<212>  DNA
<213>  Homosapiens

<400>  8527
gcccgagagg agctggggga ggacggtggc ccgcgaggct cgtcgcagac aacgcggcgg     60

cgatgtccgc gagccaggcg agtgccgcgg cggcagcggc ggggccttgc gcgcggcagg    120

gcggcctggg cttcggcctc cctccggttc cctggaagcg ggcccgcgac cagcgcggga    180

gcagcagcag aggcggaggc tccagcgcgt ctctctcctc cccctcagcc tgagccgggg    240

gaagccaggc ggcccgggtg tctggagggg gggggtccgc tgcccgagaa tgggaattct    300

cttcactaga atatggagac tgttcaatca ccagggtccg acgtccctga gtagcacggc    360

ctggcctgtc tttcagccct ttctttgctc accagttgtg tttggacacc acatagaagt    420

gctggggtct tctggaatga aggttataga ttgctgccct aaccgcacca ctgagcgacc    480

gagggttgca gaatgcggaa aacgggagga atcgctcgac ttgtccatta cacctctggt    540

ttatgagcct gccctccact gccacccgtc tttgtgtgtg tt                       582


<210>  8528
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  8528

Met Gly Ile Leu Phe Thr Arg Ile Trp Arg Leu Phe Asn His Gln Gly 
1               5                   10                  15      


Pro Thr Ser Leu Ser Ser Thr Ala Trp Pro Val Phe Gln Pro Phe Leu 
            20                  25                  30          


Cys Ser Pro Val Val Phe Gly His His Ile Glu Val Leu Gly Ser Ser 
        35                  40                  45              


Gly Met Lys Val Ile Asp Cys Cys Pro Asn Arg Thr Thr Glu Arg Pro 
    50                  55                  60                  


Arg Val Ala Glu Cys Gly Lys Arg Glu Glu Ser Leu Asp Leu Ser Ile 
65                  70                  75                  80  


Thr Pro Leu Val Tyr Glu Pro Ala Leu His Cys His Pro Ser Leu Cys 
                85                  90                  95      


<210>  8529
<211>  3121
<212>  DNA
<213>  Homosapiens

<400>  8529
agcccagcct cgggggccag ccccctccgc ccaccgcaca cgggctggcc atgcggcggc     60

tctgaacgat gtcctcctcc tcctacgcca agaacgggac cgcggacggg ccgcactccc    120

ccacctcgca ggtggcccga ggcaccacaa cccggaggag caggttgaaa agatccgatg    180

gcagcaccac ttcgaccagc ttcatcctca gacagggttc agcggattcc tacacaagca    240

ggccgtctga ctccgatgtc tctttggaag aggaccggga agcaattcga caggagagag    300

aacagcaagc agctatccag cttgagagag caaagtccaa acctgtagca tttgccgtga    360

agacaaatgt gagctactgc ggcgccctgg acgaggatgt gcctgttcca agcacagcta    420

tctcctttga tgctaaagac tttctacata ttaaagagaa atataacaat gattggtgga    480

taggaaggct ggtgaaagag ggctgtgaaa ttggcttcat tccaagtcca ctcagattgg    540

agaacatacg gatccagcaa gaacaaaaaa gaggacgttt tcacggaggg aaatcaagtg    600

gaaattcttc ttcaagtctt ggagaaatgg tatctgggac attccgagca actcccacat    660

caacagcaaa acagaagcaa aaagtgacgg agcacattcc tccttacgat gttgtaccgt    720

caatgcgtcc ggtggtgtta gtggggccgt cactgaaagg ttacgaggta acagacatga    780

tgcagaaagc cctctttgat ttcctgaagc acaggtttga tgggaggatt tcaataacga    840

gagtgacagc tgacatttct cttgctaaga ggtctgtcct aaataatccc agcaagagag    900

caataattga acgttcgaac acccggtcca gcttagcgga agtacaaagt gaaattgaaa    960

gaatctttga gttggcaaga tctttgcaac tggttgttct tgatgcagac accatcaatc   1020

acccagcaca acttataaag acttccttag caccaattat tgttcatgta aaagtctcat   1080

ctccaaaggt tttacagcgg ttgattaaat ctagaggaaa gtcacaaagt aaacacttga   1140

atgttcaact ggtggcagct gataaacttg cacaatgccc cccagaaatg tttgatgtta   1200

tattggatga aaatcagctt gaggatgcat gtgaacatct aggggagtac ctggaggcgt   1260

actggcgtgc cacccacaca accagtagca cacccatgac cccgctgctg ggaaggaatt   1320

tgggctccac ggcactctca ccatatccca cagcaatttc tgggttacag agtcagcgaa   1380

tgaggcacag caaccactcc acagagaact ctccaattga aagacgaagt ctaatgacct   1440

ctgatgaaaa ttatcacaat gaaagggctc ggaagagtag gaaccgcttg tcttccagtt   1500

ctcagcatag ccgagatcat taccctcttg tggaagaaga ttaccctgac tcataccagg   1560

acacttacaa accccatagg aaccgaggat cacctggggg atatagccat gactcccgac   1620

ataggctttg agtctaatga aacaaaaaat attcatctgt tgacaatttg ccatagcagt   1680

gctaggataa accaatcatc ttaacttggc taacatagca cagtatttac tgtgctaatg   1740

ggctgctgtc attttatgct aagtaagggg caaaaaaaaa aattacatta tgcccttgag   1800

tctagatgga tattagatgc ccgatcatat agatattttt aagtgcaaca tttacatgat   1860

aacagtacat tttgttttct tcatagattt agacacatca atttgtaatt tagggtactt   1920

acaaggcaca tataaaataa tttcccatgc tggaaattcc aaatgaccag ttccagttgg   1980

aaccaattta taaaccaatt cctgttggaa tttgggtgaa ttgactagaa agtctacttg   2040

agcatgttgt aatcaactga aaaatctggg gggaaaaaaa aaaaactaat aagaaaatcg   2100

aaataccaat agaagccaaa tccagctttg gtatttattt gctggaagct aaatttacac   2160

ttaaagttgg agtgtataaa cattttaata tatgttaatg ttgccagaat gacttttcag   2220

acttaccaaa tgtattgata gtgccaaaaa aaaaatctca gaaatcttaa tgcagaaatt   2280

atatagtctc ctcagatttt aatattttta tttctttcct ggcacagctg ttgtattcaa   2340

agtgttttgc tttttgtttg gtcagtactg ttagctcatt tgaagttggc aaaaacaaat   2400

acaaacaagc aaaaaacctc aaattttttt cagcagtgag agagaatagt aaagagaggc   2460

ccaagcatag ctggttatgt gaaatataaa atggggtgtt gttctccctt taatcaatct   2520

gagcacaact acatacatcc aggaatctga agtcagatag taaggatgtg gtaccaatcc   2580

tcccgagtgc aatgctaaac acttccaggt gggaattcat ctatttcact taacacaaac   2640

gcagggtctg tatttcctgc caacaagatt gagtatcttt ccattgcttc tctcagtctc   2700

tgtctttgaa tatctgaatg ttctggccct tcaacaaatt ctttaaatca tgctaaggaa   2760

tttcgtttta tgtggacaca ctcaactttg atattcagga gatgttttta caaaatgact   2820

aattgaaaaa agttgaaaca aatgatttta aaagcttgca gtaaaaaata aactcataga   2880

ttcagcaaat atttgttgac taaaattata gcatttttaa tgcagaaaat tataaagaat   2940

ttggagattg agctgcctta tttctaatga acactcctct tcatcttatt aagtcttcac   3000

agtttttcca gtggctataa ttatggaatt ggtgacctat gttttatatt atcaaggaag   3060

ccttagattc actctgatct aagaaattat tgaaattgac cctttttaca caaatgtctt   3120

t                                                                   3121


<210>  8530
<211>  520
<212>  PRT
<213>  Homosapiens

<400>  8530

Met Ser Ser Ser Ser Tyr Ala Lys Asn Gly Thr Ala Asp Gly Pro His 
1               5                   10                  15      


Ser Pro Thr Ser Gln Val Ala Arg Gly Thr Thr Thr Arg Arg Ser Arg 
            20                  25                  30          


Leu Lys Arg Ser Asp Gly Ser Thr Thr Ser Thr Ser Phe Ile Leu Arg 
        35                  40                  45              


Gln Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val 
    50                  55                  60                  


Ser Leu Glu Glu Asp Arg Glu Ala Ile Arg Gln Glu Arg Glu Gln Gln 
65                  70                  75                  80  


Ala Ala Ile Gln Leu Glu Arg Ala Lys Ser Lys Pro Val Ala Phe Ala 
                85                  90                  95      


Val Lys Thr Asn Val Ser Tyr Cys Gly Ala Leu Asp Glu Asp Val Pro 
            100                 105                 110         


Val Pro Ser Thr Ala Ile Ser Phe Asp Ala Lys Asp Phe Leu His Ile 
        115                 120                 125             


Lys Glu Lys Tyr Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu 
    130                 135                 140                 


Gly Cys Glu Ile Gly Phe Ile Pro Ser Pro Leu Arg Leu Glu Asn Ile 
145                 150                 155                 160 


Arg Ile Gln Gln Glu Gln Lys Arg Gly Arg Phe His Gly Gly Lys Ser 
                165                 170                 175     


Ser Gly Asn Ser Ser Ser Ser Leu Gly Glu Met Val Ser Gly Thr Phe 
            180                 185                 190         


Arg Ala Thr Pro Thr Ser Thr Ala Lys Gln Lys Gln Lys Val Thr Glu 
        195                 200                 205             


His Ile Pro Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu 
    210                 215                 220                 


Val Gly Pro Ser Leu Lys Gly Tyr Glu Val Thr Asp Met Met Gln Lys 
225                 230                 235                 240 


Ala Leu Phe Asp Phe Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile 
                245                 250                 255     


Thr Arg Val Thr Ala Asp Ile Ser Leu Ala Lys Arg Ser Val Leu Asn 
            260                 265                 270         


Asn Pro Ser Lys Arg Ala Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser 
        275                 280                 285             


Leu Ala Glu Val Gln Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg 
    290                 295                 300                 


Ser Leu Gln Leu Val Val Leu Asp Ala Asp Thr Ile Asn His Pro Ala 
305                 310                 315                 320 


Gln Leu Ile Lys Thr Ser Leu Ala Pro Ile Ile Val His Val Lys Val 
                325                 330                 335     


Ser Ser Pro Lys Val Leu Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser 
            340                 345                 350         


Gln Ser Lys His Leu Asn Val Gln Leu Val Ala Ala Asp Lys Leu Ala 
        355                 360                 365             


Gln Cys Pro Pro Glu Met Phe Asp Val Ile Leu Asp Glu Asn Gln Leu 
    370                 375                 380                 


Glu Asp Ala Cys Glu His Leu Gly Glu Tyr Leu Glu Ala Tyr Trp Arg 
385                 390                 395                 400 


Ala Thr His Thr Thr Ser Ser Thr Pro Met Thr Pro Leu Leu Gly Arg 
                405                 410                 415     


Asn Leu Gly Ser Thr Ala Leu Ser Pro Tyr Pro Thr Ala Ile Ser Gly 
            420                 425                 430         


Leu Gln Ser Gln Arg Met Arg His Ser Asn His Ser Thr Glu Asn Ser 
        435                 440                 445             


Pro Ile Glu Arg Arg Ser Leu Met Thr Ser Asp Glu Asn Tyr His Asn 
    450                 455                 460                 


Glu Arg Ala Arg Lys Ser Arg Asn Arg Leu Ser Ser Ser Ser Gln His 
465                 470                 475                 480 


Ser Arg Asp His Tyr Pro Leu Val Glu Glu Asp Tyr Pro Asp Ser Tyr 
                485                 490                 495     


Gln Asp Thr Tyr Lys Pro His Arg Asn Arg Gly Ser Pro Gly Gly Tyr 
            500                 505                 510         


Ser His Asp Ser Arg His Arg Leu 
        515                 520 


<210>  8531
<211>  2032
<212>  DNA
<213>  Homosapiens

<400>  8531
ctgtattggg aaggcagata aaatgccagg tctggactgc ctctggggat aacctcaccc     60

tgtgggatgt gaatgaatag catcttgcct ggtaaatcca caggaattga taaggcaggc    120

gcagttctcc caaacaggcc ttttctcttt aagctgtagc tgtggtttct gcagcaattt    180

tgtttttgcc ttgaaagagg tgctctggat tatcacacct ccatgtatga caatttgtac    240

ctgcatggaa ttgaagactc ggaggctggt tcagcggatt cctacacaag caggccgtct    300

gactccgatg tctctttgga agaggaccgg gaagcaattc gacaggagag agaacagcaa    360

gcagctatcc agcttgagag agcaaagtcc aaacctgtag catttgccgt gaagacaaat    420

gtgagctact gcggcgccct ggacgaggat gtgcctgttc caagcacagc tatctccttt    480

gatgctaaag actttctaca tattaaagag aaatataaca atgattggtg gataggaagg    540

ctggtgaaag agggctgtga aattggcttc attccaagtc cactcagatt ggagaacata    600

cggatccagc aagaacaaaa aagaggacgt tttcacggag ggaaatcaag tggaaattct    660

tcttcaagtc ttggagaaat ggtatctggg acattccgag caactcccac atcaacagca    720

aaacagaagc aaaaagtgac ggagcacatt cctccttacg atgttgtacc gtcaatgcgt    780

ccggtggtgt tagtggggcc gtcactgaaa ggttacgagg taacagacat gatgcagaaa    840

gccctctttg atttcctgaa gcacaggttt gatgggagga tttcaataac gagagtgaca    900

gctgacattt ctcttgctaa gaggtctgtc ctaaataatc ccagcaagag agcaataatt    960

gaacgttcga acacccggtc cagcttagcg gaagtacaaa gtgaaattga aagaatcttt   1020

gagttggcaa gatctttgca actggttgtt cttgatgcag acaccatcaa tcacccagca   1080

caacttataa agacttcctt agcaccaatt attgttcatg taaaagtctc atctccaaag   1140

gttttacagc ggttgattaa atctagagga aagtcacaaa gtaaacactt gaatgttcaa   1200

ctggtggcag ctgataaact tgcacaatgc cccccagaaa tgtttgatgt tatattggat   1260

gaaaatcagc ttgaggatgc atgtgaacat ctaggggagt acctggaggc gtactggcgt   1320

gccacccaca caaccagtag cacacccatg accccgctgc tgggaaggaa tttgggctcc   1380

acggcactct caccatatcc cacagcaatt tctgggttac agagtcagcg aatgaggcac   1440

agcaaccact ccacagagaa ctctccaatt gaaagacgaa gtctaatgac ctctgatgaa   1500

aattatcaca atgaaagggc tcggaagagt aggaaccgct tgtcttccag ttctcagcat   1560

agccgagatc attaccctct tgtggaagaa gattaccctg actcatacca ggacacttac   1620

aaaccccata ggaaccgagg atcacctggg ggatatagcc atgactcccg acataggctt   1680

tgagtctaat gaaacaaaaa atattcatct gttgacaatt tgccatagca gtgctaggat   1740

aaaccaatca tcttaacttg gctaacatag cacagtattt actgtgctaa tgggctgctg   1800

tcattttatg ctaagtaagg ggcaaaaaaa aaaattacat tatgcccttg agtctagatg   1860

gatattagat gcccgatcat atagatattt ttaagtgcaa catttacatg ataacagtac   1920

attttgtttt cttcatagat ttagacacat caatttgtaa tttagggtac ttacaaggca   1980

catataaaat aatttcccat gctggaaatt ccaaatgacc agttccagtt gg           2032


<210>  8532
<211>  486
<212>  PRT
<213>  Homosapiens

<400>  8532

Met Tyr Asp Asn Leu Tyr Leu His Gly Ile Glu Asp Ser Glu Ala Gly 
1               5                   10                  15      


Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val Ser Leu 
            20                  25                  30          


Glu Glu Asp Arg Glu Ala Ile Arg Gln Glu Arg Glu Gln Gln Ala Ala 
        35                  40                  45              


Ile Gln Leu Glu Arg Ala Lys Ser Lys Pro Val Ala Phe Ala Val Lys 
    50                  55                  60                  


Thr Asn Val Ser Tyr Cys Gly Ala Leu Asp Glu Asp Val Pro Val Pro 
65                  70                  75                  80  


Ser Thr Ala Ile Ser Phe Asp Ala Lys Asp Phe Leu His Ile Lys Glu 
                85                  90                  95      


Lys Tyr Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly Cys 
            100                 105                 110         


Glu Ile Gly Phe Ile Pro Ser Pro Leu Arg Leu Glu Asn Ile Arg Ile 
        115                 120                 125             


Gln Gln Glu Gln Lys Arg Gly Arg Phe His Gly Gly Lys Ser Ser Gly 
    130                 135                 140                 


Asn Ser Ser Ser Ser Leu Gly Glu Met Val Ser Gly Thr Phe Arg Ala 
145                 150                 155                 160 


Thr Pro Thr Ser Thr Ala Lys Gln Lys Gln Lys Val Thr Glu His Ile 
                165                 170                 175     


Pro Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu Val Gly 
            180                 185                 190         


Pro Ser Leu Lys Gly Tyr Glu Val Thr Asp Met Met Gln Lys Ala Leu 
        195                 200                 205             


Phe Asp Phe Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile Thr Arg 
    210                 215                 220                 


Val Thr Ala Asp Ile Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro 
225                 230                 235                 240 


Ser Lys Arg Ala Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser Leu Ala 
                245                 250                 255     


Glu Val Gln Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg Ser Leu 
            260                 265                 270         


Gln Leu Val Val Leu Asp Ala Asp Thr Ile Asn His Pro Ala Gln Leu 
        275                 280                 285             


Ile Lys Thr Ser Leu Ala Pro Ile Ile Val His Val Lys Val Ser Ser 
    290                 295                 300                 


Pro Lys Val Leu Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser Gln Ser 
305                 310                 315                 320 


Lys His Leu Asn Val Gln Leu Val Ala Ala Asp Lys Leu Ala Gln Cys 
                325                 330                 335     


Pro Pro Glu Met Phe Asp Val Ile Leu Asp Glu Asn Gln Leu Glu Asp 
            340                 345                 350         


Ala Cys Glu His Leu Gly Glu Tyr Leu Glu Ala Tyr Trp Arg Ala Thr 
        355                 360                 365             


His Thr Thr Ser Ser Thr Pro Met Thr Pro Leu Leu Gly Arg Asn Leu 
    370                 375                 380                 


Gly Ser Thr Ala Leu Ser Pro Tyr Pro Thr Ala Ile Ser Gly Leu Gln 
385                 390                 395                 400 


Ser Gln Arg Met Arg His Ser Asn His Ser Thr Glu Asn Ser Pro Ile 
                405                 410                 415     


Glu Arg Arg Ser Leu Met Thr Ser Asp Glu Asn Tyr His Asn Glu Arg 
            420                 425                 430         


Ala Arg Lys Ser Arg Asn Arg Leu Ser Ser Ser Ser Gln His Ser Arg 
        435                 440                 445             


Asp His Tyr Pro Leu Val Glu Glu Asp Tyr Pro Asp Ser Tyr Gln Asp 
    450                 455                 460                 


Thr Tyr Lys Pro His Arg Asn Arg Gly Ser Pro Gly Gly Tyr Ser His 
465                 470                 475                 480 


Asp Ser Arg His Arg Leu 
                485     


<210>  8533
<211>  5335
<212>  DNA
<213>  Homosapiens

<400>  8533
cacctccatg tatgacaatt tgtacctgca tggaattgaa gactcggagg ctggttcagc     60

ggattcctac acaagcaggc cgtctgactc cgatgtctct ttggaagagg accgggaagc    120

aattcgacag gagagagaac agcaagcagc tatccagctt gagagagcaa agtccaaacc    180

tgtagcattt gccgtgaaga caaatgtgag ctactgcggc gccctggacg aggatgtgcc    240

tgttccaagc acagctatct cctttgatgc taaagacttt ctacatatta aagagaaata    300

taacaatgat tggtggatag gaaggctggt gaaagagggc tgtgaaattg gcttcattcc    360

aagtccactc agattggaga acatacggat ccagcaagaa caaaaaagag gacgttttca    420

cggagggaaa tcaagtggaa attcttcttc aagtcttgga gaaatggtat ctgggacatt    480

ccgagcaact cccacatcaa cagcaaaaca gaagcaaaaa gtgacggagc acattcctcc    540

ttacgatgtt gtaccgtcaa tgcgtccggt ggtgttagtg gggccgtcac tgaaaggtta    600

cgaggtacaa atatcatctg ttactcttca gttcttgatc gagcacccag gagacagtca    660

tgttgacgct tgctcctcaa gggtctgttt ccacgtgggt cctgatggaa gccagtgctc    720

agcatgggaa ggcagggggt accgtgtggg gctcatgagg ccctctgccc tttctttcct    780

ctcttgcaca cttctcatct tttatgtatt acattgttta gaaatacctc cctcaaaata    840

ttcacaatgg gaagatctgg tcaaagattt gctgtacatt aaatgcaaag aaaaggactt    900

tatctgtctt gaccattctc attattatta gaagtaatag agaatgaaca gcacaagagg    960

acaaacaatc aatcttccag caaacccaaa cctttaaagc ccaaacagag ttcaccctgc   1020

tgggttttta agatgatggc atatgccacc aaatccttct ctgcttattt attttaaagg   1080

gcacatgttt taaaagacca ctaaaaacat tagtgaactt tggagattaa acaaaaccat   1140

gtgacaagga aaagagtaga gacttcgttt cagatgtttg ttttgacttt gtgctagctt   1200

ggattaaaaa ataggtagaa cgtgacatta aactctgaag gtgagcagcc tccagggcac   1260

cattcccatc gagctaggac aatgtgtggc acatagtagg cactcagtac acatttgctg   1320

aatgaattaa tgaatcgctt tcaggcagat ctaagaatcc tggctctatc cccctctctt   1380

tctctcttgt ctttctcaga gttggaaatg tcagagggat gagcaggaga gtggtctaca   1440

aaaatccagc catgggcatg gagaatttcc gccaacatac acaaactagc aggaaggctg   1500

agtccagtgc tggcctcagt tctctagctg ctcctcactg gaggcaggca caactcaggc   1560

gtgccaagga tacccggcac ctgtgtacaa agccagcctg ttgtctcctg gcagcagttc   1620

tatcccctaa cgagggaaga gggaagaggg aagagggtct ggtgaacact gctggtttat   1680

tcctcaacac cctggaggag aaccaagggg ggtggaaatt agcaattgca catggttaag   1740

catgaaaaac accttccatg gtaacctccc cctaggagac gaatggctac aataaggtct   1800

tggctcatag tacccttccc tccctcctct ctcccttttg acttctctct ctctctctgc   1860

atgtgtttgc ctcattcttt ttttctcacc tctgcaaagg taacagacat gatgcagaaa   1920

gccctctttg atttcctgaa gcacaggttt gatgggaggt gagaaatata gatgtttttg   1980

tatttttatt ttcctttaac caaacttgtg tgataaattg aattgtagat ctatgtttcc   2040

agagatttca gaagttctct agttaaaagt taactcagta ttcttgggaa gaatataata   2100

aaagaactct gaaaatatga agtataacat tgagtcccca gtgaagaaag gaccatgaga   2160

agaaaaataa gccatttgtt ttatttaaat gtatatatct ttattttctc agttattaat   2220

aatttcatac caaaatgttt tttatgaaaa aatattaatt aaaatatata atatttctca   2280

tgagtatagt ggcttgctgg tcaaactagg cagtatttgg gaattgtgta tgtgtgtgtg   2340

tgtgtgtgtg tgtgtgtgtg tgtcatatga aagcataaat gtcaagtact gaatttcctc   2400

aaaagaagag agtgagaatt attttaatca taagcctccc aaagtgatca ttttgtaggg   2460

aatagtactt atttggatat ttattatagt tgtgggttgt ttttattaga aatgtccttg   2520

ttattttatt gatctttttt taatgtattt tactatgatc catcaacaat atggctcagg   2580

cattagccat taaataattt tatcatttaa gttttgtgaa aaattctaaa gaaagtttct   2640

ctgttttgca gagaaatggt aaaaagcctg tattgactca attctaaata ttaagctctt   2700

tcacagtgct gaatgcagtc catgtaaaaa taaccacatg aaaaaacctg agatttatca   2760

gaaatgtagg aaatttaaat ggggtgcatc aaaaagtatg ggcaaatgca tccagtttat   2820

tactgtagga ttgaagaaaa acatcacatt ctttattttt gaaggcagta attaagccat   2880

tcactttctc tttgctaaat tatgagaatc cactaaatgc acaaaataat tttaaaatgt   2940

aaaaaaactt cagatagatt ttaataaatt ggtatattaa gaataaaaac aagcatggta   3000

ttgctttaaa tataaattgt atgcatttgt taaaataaaa gctttctgga taattgggta   3060

aaatattcat tagtttctgg aacaatatag aaagttagta aacagatttt agtttaagaa   3120

ataagaatgc ttctaggtac attagtatat aggtcaggct gccttaataa atagacccca   3180

aaatgtgtag tgattcaaac acaatggaag cttattattg ctcacttaac agtctgaagc   3240

aggtgttcct tggctgggag ggaggataga gttgggggag gggagaattg ggcagaaagt   3300

ttgttccctc tgtcatttgg ggcccttagc ccaggtacga tgtctctagt cagcttgccc   3360

ggcctggagg tagcgcaact gacatttcac tggttagaac ttggttatgt ggtcatactt   3420

aattgcagcg gaggcactct tgcagtccag gaggaagagg agatagaatt tgttgaatca   3480

ataatagcct tcgtcacatt catctactgg acaaaggctt aataagaaag atgtatttgt   3540

tccatttcac tctctttaaa aaagaaatag gcagataatg aagtagcttc aaagaaaata   3600

agttaaaagc cctgaatcct agagcattgg agttggaagg atacataaaa tgtcttttag   3660

actcatcatt tctccaataa ccacaatcag atagacaacc tgcttctgtt tgaaactttt   3720

ggttattggg attacacttt ctaaaaaagc attgcaaaaa aatagctgaa ctctgacttt   3780

gtaacttaat agggctggtc ttggtcttgc tgtctgatgc tctggcctta accctaaccc   3840

tcatgcaggt ccctgtggat tgaaggcagc cagcatgcct tggtcgcacg tgcatagttc   3900

cttcagatat gtatggagtc acatggtttc aacctgtgga gctgttacct aaggcagttc   3960

tgagcagtgc cgaatccact ggccccataa cagccctatc tgaacaaatc ccatcccata   4020

agacagtgtt agattatttt ggtctataac atacttatac gcaacagtgc tgttaaaggt   4080

ttgccctcaa gaatgaagaa tctgatgttc ttcctcaatc ctgaggccca gaaaaaggga   4140

atttatttaa ttgtaacagc agagatttgt ctcgaatcaa gtagaattgt cgcatccatt   4200

actgtacaca tactactgaa gttggtttta atagaaattg aatgcaaatt tcaatctcaa   4260

gtattcatgg ggtctgatga catggcagag ggtctggagg aagagcccag cagtagcaaa   4320

agtaatagct gaagagagag acttagccct ggagaaatct gatatatttc tccagcagga   4380

gaaagatagg tagatattaa aggggtgagg ggtgagagaa tggacttgat ttcaaatatt   4440

aagaggccag gcagcagaat gaacaataag gagttccttg gttgagtgta tgtggagact   4500

ttgataagaa agaaattcgc tggtagcgtc acactgactc tgacatgtct tcttcgtggg   4560

gaatatcgtt aggttttgag ctataacatc atgctgcatt atgttttacc aattgataca   4620

aggagagaaa aaaacaaata gtctttaatt gaaaccagcc aagagaacaa tgacaaggaa   4680

ggctttagca cagtgacacg gcataaacaa tatgttctaa tggaaaccta ctctgtgttt   4740

catgggctat gaatgcagta cgttagacaa aataggagaa agtcctatta tttttcagaa   4800

agtacaaaga agggatctgt tggctacgag gctttcttct ttaatctgct tttcagatct   4860

tagtagaaaa taattcaaca aattggatga aagtccaaca gtttgactat tgcagaatca   4920

taaacttggg atttttttga taccttagaa attatttgag tcagtttaga gctacttatt   4980

atacaatttt attgctgtag ctgctattgt ggggcctaac tgtaatacat gtaagaaaaa   5040

cagaatacta ggctgggcgc agtggctcat gcctataatc ccagcacttt gggaggccca   5100

ggtgggcaga tcacctgagg tcgggagttc gagaccagcc tgaccaacat ggagaaacct   5160

catctctaat aaaaatacaa aattagccag gcgtggtggc gcgtgcctgt aattccagcc   5220

actcgggagg ctgaggcagg aaaatcactt gaacctggga ggcagaggtt gcggtgagcc   5280

aagatcatgc cattgcactc cagcctgggc aataggagca aaactctgtc tcaat        5335


<210>  8534
<211>  307
<212>  PRT
<213>  Homosapiens

<400>  8534

Met Tyr Asp Asn Leu Tyr Leu His Gly Ile Glu Asp Ser Glu Ala Gly 
1               5                   10                  15      


Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val Ser Leu 
            20                  25                  30          


Glu Glu Asp Arg Glu Ala Ile Arg Gln Glu Arg Glu Gln Gln Ala Ala 
        35                  40                  45              


Ile Gln Leu Glu Arg Ala Lys Ser Lys Pro Val Ala Phe Ala Val Lys 
    50                  55                  60                  


Thr Asn Val Ser Tyr Cys Gly Ala Leu Asp Glu Asp Val Pro Val Pro 
65                  70                  75                  80  


Ser Thr Ala Ile Ser Phe Asp Ala Lys Asp Phe Leu His Ile Lys Glu 
                85                  90                  95      


Lys Tyr Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly Cys 
            100                 105                 110         


Glu Ile Gly Phe Ile Pro Ser Pro Leu Arg Leu Glu Asn Ile Arg Ile 
        115                 120                 125             


Gln Gln Glu Gln Lys Arg Gly Arg Phe His Gly Gly Lys Ser Ser Gly 
    130                 135                 140                 


Asn Ser Ser Ser Ser Leu Gly Glu Met Val Ser Gly Thr Phe Arg Ala 
145                 150                 155                 160 


Thr Pro Thr Ser Thr Ala Lys Gln Lys Gln Lys Val Thr Glu His Ile 
                165                 170                 175     


Pro Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu Val Gly 
            180                 185                 190         


Pro Ser Leu Lys Gly Tyr Glu Val Gln Ile Ser Ser Val Thr Leu Gln 
        195                 200                 205             


Phe Leu Ile Glu His Pro Gly Asp Ser His Val Asp Ala Cys Ser Ser 
    210                 215                 220                 


Arg Val Cys Phe His Val Gly Pro Asp Gly Ser Gln Cys Ser Ala Trp 
225                 230                 235                 240 


Glu Gly Arg Gly Tyr Arg Val Gly Leu Met Arg Pro Ser Ala Leu Ser 
                245                 250                 255     


Phe Leu Ser Cys Thr Leu Leu Ile Phe Tyr Val Leu His Cys Leu Glu 
            260                 265                 270         


Ile Pro Pro Ser Lys Tyr Ser Gln Trp Glu Asp Leu Val Lys Asp Leu 
        275                 280                 285             


Leu Tyr Ile Lys Cys Lys Glu Lys Asp Phe Ile Cys Leu Asp His Ser 
    290                 295                 300                 


His Tyr Tyr 
305         


<210>  8535
<211>  4168
<212>  DNA
<213>  Homosapiens

<400>  8535
agcggaggct ttgctgtggc agctgctgga gcggcggccg cctcgggagc cggaggagag     60

gcagccgcgg agcgccgagc tggcctcgcc ccgaggcccg gccctgggtg tggggaaccg    120

cgctgaggag ctggaaactt tcccggcagg agctgactgc tgggcaggaa cgtctctcag    180

gagaaagagt ggaagagaaa attgtgaact aaggccccct gccccctttt cctggtgcat    240

gtgaagttat caaaaacaga aacaagtgtt gaaaatgtta aaggctgtgc tgaagaagag    300

ccgagaggga ggaaagggag gcaagaagga agcaggaagt gactttggtc cagagacttc    360

tccagtcctg caccttgacc acagtgctga ctctcctgtg agcagtcttc ccacagcaga    420

ggacacctat agggtgagct tggccaaagg tgtctcgatg tctctgcctt cctcaccttt    480

gctgcctcga cagtctcact tggtgcaatc aagagtgaac aaaaaatccc caggtcccgt    540

caggaagccc aagtatgtgg aaagccccag agtgcctgga gatgcagtta taatgccatt    600

cagagaagta gccaagccaa cagagcctga tgagcatgcc acaattacaa gttcatccga    660

aaatgatgac cggagtggct ccagtttgga atggaataaa gatggaaacc taagattagg    720

ggttcagaag ggagtgcttc atgaccgcag ggcagataac tgctccccag tggcagaaga    780

ggagaccacc gggtcagcag agagcacgct gcccaaagca gaatcctcag ctggagatgg    840

tccagtccct tattctcagg gctccagctc actaataatg ccacggccca actcagttgc    900

agcaacaagc tcaaccaaat tggaagatct gagttattta gacgggcaga gaaatgctcc    960

tctacggacg tcaattagat taccatggca caatacggcc ggaggtaggg cacaggaagt   1020

taaagcacga tttgctccct acaagccaca agacattttg ttgaaaccct tgttgtttga   1080

agtaccaagc ataacaacag actctgtgtt tgtgggaagg gattggctct ttcaccagat   1140

agaagaaaac ttgaggaaca cagaactggc agaaaacaga ggcgcggtgg tggttggcaa   1200

tgtgggattt gggaagacgg caatcatttc caagttggtg gccctgagct gccacggaag   1260

ccgcatgagg cagattgctt ccaacagccc gggttcatca cctaaaacct ctgaccccac   1320

tcaggatctt catttcactc cgttgctttc accgagttct tccacaagtg cttccagcac   1380

agctaaaaca cctcttgggt ctatcagtgc tgaaaaccag agaccaagag aggatgcagt   1440

gaaatatctt gcttctaagg tggtggccta ccactactgc caggctgaca acacgtacac   1500

ttgcctggtg cccgagtttg tgcacagcat cgcagctttg ctctgccggt cccatcagct   1560

ggccgcctac agagaccttc tgataaagga gccccaacta cagagcatgc tgagcctccg   1620

atcctgtgtg caggacccgg tggcagcttt caagagggga gtgctggagc cactcacaaa   1680

cctgagaaat gagcagaaaa ttcctgaaga agaatacatt attttgatag atggcttaaa   1740

tgaagctgag tttcataaac ctgattatgg agatacgctt tcttcattta ttaccaaaat   1800

tatttctaaa tttcctgcct ggttgaagtt gattgtgact gtaagagcaa attttcagga   1860

aatcataagt gcgctgccat ttgtcaagct ttccttagat gacttcccag acaacaaaga   1920

catccacagt gacctgcacg cctacccagc agcataaaga tgtcaagttc aaccagtagt   1980

ttgacttcga gcagcagttt ttcagatggc ttcaaggtcc aaggaccaga tactagaatt   2040

aaagacaagg ttgtaaccca cgttcagagc ggtacagctg agcacagacc ccgcaacacg   2100

ccgttcatgg gcatcatgga taagactgcg aggttccaac agcagagcaa tcctccaagc   2160

cgcagctggc actgtccggc accagagggg ctgctgacaa acacgtcttc tgcagctggc   2220

ctgcagtctg ctaacactga gaagccctct ctcatgcaag tgggaggata taataaccaa   2280

gccaaaacct gttctgtttc taccctgagt gcaagtgtcc acaatggggc acaagtgaag   2340

gagctagaag aaagcaagtg ccaaattcca gtccactctc aagagaacag gataactaag   2400

actgtttctc atctgtacca ggaaagtatc tccaaacagc agcctcatat tagtaatgaa   2460

gcccacagga gccacctcac tgcagccaaa ccaaagcgat catttataga gtcaaatgtg   2520

tgaaccttaa gaaatcccca tttgtggaat ttggaaacgt gtgttgactc ctggtggtaa   2580

attaaatagt ttttttcatc agaaaaatta ttttttagcc attttttttc tttggggtgg   2640

atctgatgcc attgatatat ctaaaatgtg ggataaaact tctttaatag ctagaaatca   2700

ccataaataa gaatgctaaa cagaattgaa aattatatca acttaaaatt ttaagacagc   2760

ccagaagaca ttaatgactc tcacttatga aattgtttgg cttttgccac tttcttcctt   2820

gcctttgcta tatggtagaa tcacagaact tacttagaga ataaatatgt ctattgttca   2880

agagtaacag gtttaactca tgaccaagtg atgtacatcc aagtgatgta ttctggaaac   2940

gatggaattt tacagttaca gttccattga gtcaaatccc attttatata tacataaaaa   3000

ttaagttctg agtgagttct agctaaatat aagtgcgact gtaaacgcag ccaatttttt   3060

taagcagaat atgagaacac ctaagtattc tcttcatagc agttcctata aagggattaa   3120

acacttattt ctgtgttatg gttcttattc atatattttt atagcacttt tggaacctat   3180

atttgtgctt gaaggtgttt ttgatatttg gaaacagtat aagccatttg gagtcatgat   3240

tggtggtcaa gtggattcaa gctaaaatac taagaccagc attcttagtg gcgcttataa   3300

attagctctc acctggtttc caaactgctt ttaacaatgg tagtgctcct ggaacaatcc   3360

ttccaagctc ctctaaggac aatatttaat tcagatacta aaggtaagac tggttgttac   3420

ttttgttttg ttgtacaatt agtactttat agtcacatgt tgtatatatt aaatagccca   3480

gttttattca gacttgtaaa tagaactatt tcaatgtagt taatctaaaa acaaaaaaga   3540

aaaccccagt cacgatttgc atgttctctg taagcttcat ccatgctggt tattgcactg   3600

aatgatatat tattagggca tgttaacagt ataccagtaa cagcacttta tctcatttat   3660

atgaacacct ttgaggtgct acttaagtcc aagctctgat gtattattca tttgtaaaga   3720

taaggtacag gaatgaacct tggtttaaag gtatttttat atgaaaatgg tgtgttattg   3780

gaagatgtta aaatgctaat ttgagagaag taggagtgta tctgttttat atgttgggat   3840

gtgaaattta ttttctaaaa ttgaggagaa ggaagttata tatttgcaga atgttttaaa   3900

gtgaattgtt gtaatgaagt tcctgtgaac atcattatgg ttttgtacaa ataggaacct   3960

ctgatgtcat tcttcaacgt ttgttcctgt gtgtacaatt gtactttgta tgaacagctt   4020

tatcattttt ataggctttc catgagtttt gctgtaacta ctatggctta tttattttct   4080

ttaatatttg tgaaagtctt actcctttgt tagttttgtt tctgcacaac tactgtactt   4140

ttccatatgg aataaagact attaatag                                      4168


<210>  8536
<211>  560
<212>  PRT
<213>  Homosapiens

<400>  8536

Met Leu Lys Ala Val Leu Lys Lys Ser Arg Glu Gly Gly Lys Gly Gly 
1               5                   10                  15      


Lys Lys Glu Ala Gly Ser Asp Phe Gly Pro Glu Thr Ser Pro Val Leu 
            20                  25                  30          


His Leu Asp His Ser Ala Asp Ser Pro Val Ser Ser Leu Pro Thr Ala 
        35                  40                  45              


Glu Asp Thr Tyr Arg Val Ser Leu Ala Lys Gly Val Ser Met Ser Leu 
    50                  55                  60                  


Pro Ser Ser Pro Leu Leu Pro Arg Gln Ser His Leu Val Gln Ser Arg 
65                  70                  75                  80  


Val Asn Lys Lys Ser Pro Gly Pro Val Arg Lys Pro Lys Tyr Val Glu 
                85                  90                  95      


Ser Pro Arg Val Pro Gly Asp Ala Val Ile Met Pro Phe Arg Glu Val 
            100                 105                 110         


Ala Lys Pro Thr Glu Pro Asp Glu His Ala Thr Ile Thr Ser Ser Ser 
        115                 120                 125             


Glu Asn Asp Asp Arg Ser Gly Ser Ser Leu Glu Trp Asn Lys Asp Gly 
    130                 135                 140                 


Asn Leu Arg Leu Gly Val Gln Lys Gly Val Leu His Asp Arg Arg Ala 
145                 150                 155                 160 


Asp Asn Cys Ser Pro Val Ala Glu Glu Glu Thr Thr Gly Ser Ala Glu 
                165                 170                 175     


Ser Thr Leu Pro Lys Ala Glu Ser Ser Ala Gly Asp Gly Pro Val Pro 
            180                 185                 190         


Tyr Ser Gln Gly Ser Ser Ser Leu Ile Met Pro Arg Pro Asn Ser Val 
        195                 200                 205             


Ala Ala Thr Ser Ser Thr Lys Leu Glu Asp Leu Ser Tyr Leu Asp Gly 
    210                 215                 220                 


Gln Arg Asn Ala Pro Leu Arg Thr Ser Ile Arg Leu Pro Trp His Asn 
225                 230                 235                 240 


Thr Ala Gly Gly Arg Ala Gln Glu Val Lys Ala Arg Phe Ala Pro Tyr 
                245                 250                 255     


Lys Pro Gln Asp Ile Leu Leu Lys Pro Leu Leu Phe Glu Val Pro Ser 
            260                 265                 270         


Ile Thr Thr Asp Ser Val Phe Val Gly Arg Asp Trp Leu Phe His Gln 
        275                 280                 285             


Ile Glu Glu Asn Leu Arg Asn Thr Glu Leu Ala Glu Asn Arg Gly Ala 
    290                 295                 300                 


Val Val Val Gly Asn Val Gly Phe Gly Lys Thr Ala Ile Ile Ser Lys 
305                 310                 315                 320 


Leu Val Ala Leu Ser Cys His Gly Ser Arg Met Arg Gln Ile Ala Ser 
                325                 330                 335     


Asn Ser Pro Gly Ser Ser Pro Lys Thr Ser Asp Pro Thr Gln Asp Leu 
            340                 345                 350         


His Phe Thr Pro Leu Leu Ser Pro Ser Ser Ser Thr Ser Ala Ser Ser 
        355                 360                 365             


Thr Ala Lys Thr Pro Leu Gly Ser Ile Ser Ala Glu Asn Gln Arg Pro 
    370                 375                 380                 


Arg Glu Asp Ala Val Lys Tyr Leu Ala Ser Lys Val Val Ala Tyr His 
385                 390                 395                 400 


Tyr Cys Gln Ala Asp Asn Thr Tyr Thr Cys Leu Val Pro Glu Phe Val 
                405                 410                 415     


His Ser Ile Ala Ala Leu Leu Cys Arg Ser His Gln Leu Ala Ala Tyr 
            420                 425                 430         


Arg Asp Leu Leu Ile Lys Glu Pro Gln Leu Gln Ser Met Leu Ser Leu 
        435                 440                 445             


Arg Ser Cys Val Gln Asp Pro Val Ala Ala Phe Lys Arg Gly Val Leu 
    450                 455                 460                 


Glu Pro Leu Thr Asn Leu Arg Asn Glu Gln Lys Ile Pro Glu Glu Glu 
465                 470                 475                 480 


Tyr Ile Ile Leu Ile Asp Gly Leu Asn Glu Ala Glu Phe His Lys Pro 
                485                 490                 495     


Asp Tyr Gly Asp Thr Leu Ser Ser Phe Ile Thr Lys Ile Ile Ser Lys 
            500                 505                 510         


Phe Pro Ala Trp Leu Lys Leu Ile Val Thr Val Arg Ala Asn Phe Gln 
        515                 520                 525             


Glu Ile Ile Ser Ala Leu Pro Phe Val Lys Leu Ser Leu Asp Asp Phe 
    530                 535                 540                 


Pro Asp Asn Lys Asp Ile His Ser Asp Leu His Ala Tyr Pro Ala Ala 
545                 550                 555                 560 


<210>  8537
<211>  5382
<212>  DNA
<213>  Homosapiens

<400>  8537
gctgtggcag ctgctggagc ggcggccgcc tcgggagccg gaggagaggc agccgcggag     60

cgccgagctg gcctcgcccc gaggcccggc cctgggtgtg gggaaccgcg ctgaggagct    120

ggaaactttc ccggcaggag ctgactgctg ggcaggaacg tctctcagga gaaagagtgg    180

aagagaaaat tgtgaactaa ggccccctgc ccccttttcc tggtgcatgt gaagttatca    240

aaaacagaaa caagtgttga aaatgttaaa ggctgtgctg aagaagagcc gagagggagg    300

aaagggaggc aagaaggaag caggaagtga ctttggtcca gagacttctc cagtcctgca    360

ccttgaccac agtgctgact ctcctgtgag cagtcttccc acagcagagg acacctatag    420

ggtgagcttg gccaaaggtg tctcgatgtc tctgccttcc tcacctttgc tgcctcgaca    480

gtctcacttg gtgcaatcaa gagtgaacaa aaaatcccca ggtcccgtca ggaagcccaa    540

gtatgtggaa agccccagag tgcctggaga tgcagttata atgccattca gagaagtagc    600

caagccaaca gagcctgatg agcatgaagc aaaggccgat aatgaaccga gctgttcgcc    660

ggcagctcaa gaactgttga caaggctggg atttttactg ggagaaggga tcccaagtgc    720

cacacacata accattgaag acaaaaatga aaccatgtgc acagctctga gtcaaggcat    780

cagtccttgc tccacactaa caagcagcac cgcatctcct agcaccgata gcccctgctc    840

aaccttgaat agctgtgtca gcaagacggc agccaacaaa agtccctgtg agaccattag    900

cagccctagt tccaccctgg aaagcaagga cagtggaatt atagccacaa ttacaagttc    960

atccgaaaat gatgaccgga gtggctccag tttggaatgg aataaagatg gagaaggaac   1020

atgaagtaga agtcaatggc accgacacat tgtggggaga aacagccctg actgccgccg   1080

caggaagagg gaagctggag gtctgtgagc tgctgctggg gcatggagct gctgtgtcgc   1140

ggacaaacag gagaggggtt ccacctttgt tttgtgcagc acgccagggg cattggcaga   1200

ttgttagact gctgttggaa cgcggctgtg atgtgaacct aagtgacaag caaggccgga   1260

cgcccctcat ggtggctgct tgtgaagggc acttgagcac cgtggaattc ctcctttcaa   1320

aaggtagcag cgtgatgccc tcaaaggttt cttttggacg gacacagaga gaacttcagc   1380

agacccattc agtgctttct gattcaaatt ctaagttttc tgttaatgga aattttctaa   1440

taaacagtag agagaatagg caacacagcc acatgcctgg tattcctctt cagcagcgat   1500

gaccattctg ccagcccatc cggccagtgt cacccttcac agtgcttgac tgacacttgg   1560

ttcaggccgg gtgttccgca ggtgtgaaac aatttgcttt ctggctttgt catctcataa   1620

tgttcatgtt ctgtgaatgg gctttccttt caggtgcagc cctttcttct ctagacaaag   1680

agggtctgtc agcattaagc tgggcttgtc tgaaaggtca cagggcagtg gtccagtatc   1740

tggttgaaga aggagctgca atagaccaga cagacaagaa tggccgcaca cccttggacc   1800

tggctgcctt ctatggcgat gccgagactg tgctgtacct ggtggagaag ggagccgtga   1860

tcgagcatgt ggaccacagc gggatgcggc ccttggacag agccatcggc tgccggaaca   1920

catctgtagt ggtggcgcta ctcagaaagg gagccaagtt aggaaatgct gcttgggcga   1980

tggccacttc caaacctgat atcttgatta tacttttaca gaaattaatg gaggaaggaa   2040

atgtgatgta caaaaaaggg aaaatgaaag aggcagccca gaggtaccag tatgccttaa   2100

gaaagtttcc tcgagaagga ttcggagagg acatgagacc cttcaatgaa ttaagggttt   2160

ccctctatct caatttgtcg cgatgccgaa gaaaaacaaa tgactttggc atggcagagg   2220

aatttgcttc caaggctctc gaattgaagc ccaagtccta tgaagccttt tatgccagag   2280

caagagcgaa gagaaatagc aggcaattcg tggcagctct ggctgacctg caagaggctg   2340

tgaaactctg tcccaccaat caggaagtca agaggcttct ggcccgcgta gaagaggagt   2400

gcaaacaact ccagaggagt caacagcaaa aacagcaggg cccgctacca gctccactca   2460

acgactccga gaacgaagag gacaccccaa cccctggctt aagtgaccac tttcactctg   2520

aggagactga agaggaagaa acttctcccc aggaagaatc tgtttcccca actcccaggt   2580

cccagccatc ctcatctgtc ccttcctcat acatccgaaa ccttcaagaa gggttacagt   2640

ccaaaggaag gccggtatcg ccacagagca gggcaggaat cggcaagtcc ctgagagagc   2700

ctgtggccca gccagggctg ctcctgcagc cctccaagca ggcccagatc gtgaaaacca   2760

gccagcacct gggctctggc cagtcggcag tgagaaatgg cagtatgaaa gttcagatct   2820

cttctcagaa ccctcctcca agtcccatgc cagggagaat cgctgccact cctgctggga   2880

gcagaaccca gcatttagag ggaacaggta ctttcactac aagagctggt tgtggccact   2940

ttggggatcg gctgggcccc agccagaatg tccgcctgca gtgtggtgag aatggccctg   3000

cacacccttt accaagtaag acgaaaacca cagagaggct tctgtctcat tcctccgtgg   3060

ctgtggacgc agcccctcca aaccaaggtg ggctggcgac ctgcagcgac gtgcgacacc   3120

cagcttccct caccagctca ggctcttctg gttctccatc cagcagcata aagatgtcaa   3180

gttcaaccag tagtttgact tcgagcagca gtttttcaga tggcttcaag gtccaaggac   3240

cagatactag aattaaagac aaggttgtaa cccacgttca gagcggtaca gctgagcaca   3300

gaccccgcaa cacgccgttc atgggcatca tggataagac tgcgaggttc caacagcaga   3360

gcaatcctcc aagccgcagc tggcactgtc cggcaccaga ggggctgctg acaaacacgt   3420

cttctgcagc tggcctgcag tctgctaaca ctgagaagcc ctctctcatg caagtgggag   3480

gatataataa ccaagccaaa acctgttctg tttctaccct gagtgcaagt gtccacaatg   3540

gggcacaagt gaaggagcta gaagaaagca agtgccaaat tccagtccac tctcaagaga   3600

acaggataac taagactgtt tctcatctgt accaggaaag tatctccaaa cagcagcctc   3660

atattagtaa tgaagcccac aggagccacc tcactgcagc caaaccaaag cgatcattta   3720

tagagtcaaa tgtgtgaacc ttaagaaatc cccatttgtg gaatttggaa acgtgtgttg   3780

actcctggtg gtaaattaaa tagttttttt catcagaaaa attatttttt agccattttt   3840

tttctttggg gtggatctga tgccattgat atatctaaaa tgtgggataa aacttcttta   3900

atagctagaa atcaccataa ataagaatgc taaacagaat tgaaaattat atcaacttaa   3960

aattttaaga cagcccagaa gacattaatg actctcactt atgaaattgt ttggcttttg   4020

ccactttctt ccttgccttt gctatatggt agaatcacag aacttactta gagaataaat   4080

atgtctattg ttcaagagta acaggtttaa ctcatgacca agtgatgtac atccaagtga   4140

tgtattctgg aaacgatgga attttacagt tacagttcca ttgagtcaaa tcccatttta   4200

tatatacata aaaattaagt tctgagtgag ttctagctaa atataagtgc gactgtaaac   4260

gcagccaatt tttttaagca gaatatgaga acacctaagt attctcttca tagcagttcc   4320

tataaaggga ttaaacactt atttctgtgt tatggttctt attcatatat ttttatagca   4380

cttttggaac ctatatttgt gcttgaaggt gtttttgata tttggaaaca gtataagcca   4440

tttggagtca tgattggtgg tcaagtggat tcaagctaaa atactaagac cagcattctt   4500

agtggcgctt ataaattagc tctcacctgg tttccaaact gcttttaaca atggtagtgc   4560

tcctggaaca atccttccaa gctcctctaa ggacaatatt taattcagat actaaaggta   4620

agactggttg ttacttttgt tttgttgtac aattagtact ttatagtcac atgttgtata   4680

tattaaatag cccagtttta ttcagacttg taaatagaac tatttcaatg tagttaatct   4740

aaaaacaaaa aagaaaaccc cagtcacgat ttgcatgttc tctgtaagct tcatccatgc   4800

tggttattgc actgaatgat atattattag ggcatgttaa cagtatacca gtaacagcac   4860

tttatctcat ttatatgaac acctttgagg tgctacttaa gtccaagctc tgatgtatta   4920

ttcatttgta aagataaggt acaggaatga accttggttt aaaggtattt ttatatgaaa   4980

atggtgtgtt attggaagat gttaaaatgc taatttgaga gaagtaggag tgtatctgtt   5040

ttatatgttg ggatgtgaaa tttattttct aaaattgagg agaaggaagt tatatatttg   5100

cagaatgttt taaagtgaat tgttgtaatg aagttcctgt gaacatcatt atggttttgt   5160

acaaatagga acctctgatg tcattcttca acgtttgttc ctgtgtgtac aattgtactt   5220

tgtatgaaca gctttatcat ttttataggc tttccatgag ttttgctgta actactatgg   5280

cttatttatt ttctttaata tttgtgaaag tcttactcct ttgttagttt tgtttctgca   5340

caactactgt acttttccat atggaataaa gactattaat ag                      5382


<210>  8538
<211>  705
<212>  PRT
<213>  Homosapiens

<400>  8538

Met Phe Met Phe Cys Glu Trp Ala Phe Leu Ser Gly Ala Ala Leu Ser 
1               5                   10                  15      


Ser Leu Asp Lys Glu Gly Leu Ser Ala Leu Ser Trp Ala Cys Leu Lys 
            20                  25                  30          


Gly His Arg Ala Val Val Gln Tyr Leu Val Glu Glu Gly Ala Ala Ile 
        35                  40                  45              


Asp Gln Thr Asp Lys Asn Gly Arg Thr Pro Leu Asp Leu Ala Ala Phe 
    50                  55                  60                  


Tyr Gly Asp Ala Glu Thr Val Leu Tyr Leu Val Glu Lys Gly Ala Val 
65                  70                  75                  80  


Ile Glu His Val Asp His Ser Gly Met Arg Pro Leu Asp Arg Ala Ile 
                85                  90                  95      


Gly Cys Arg Asn Thr Ser Val Val Val Ala Leu Leu Arg Lys Gly Ala 
            100                 105                 110         


Lys Leu Gly Asn Ala Ala Trp Ala Met Ala Thr Ser Lys Pro Asp Ile 
        115                 120                 125             


Leu Ile Ile Leu Leu Gln Lys Leu Met Glu Glu Gly Asn Val Met Tyr 
    130                 135                 140                 


Lys Lys Gly Lys Met Lys Glu Ala Ala Gln Arg Tyr Gln Tyr Ala Leu 
145                 150                 155                 160 


Arg Lys Phe Pro Arg Glu Gly Phe Gly Glu Asp Met Arg Pro Phe Asn 
                165                 170                 175     


Glu Leu Arg Val Ser Leu Tyr Leu Asn Leu Ser Arg Cys Arg Arg Lys 
            180                 185                 190         


Thr Asn Asp Phe Gly Met Ala Glu Glu Phe Ala Ser Lys Ala Leu Glu 
        195                 200                 205             


Leu Lys Pro Lys Ser Tyr Glu Ala Phe Tyr Ala Arg Ala Arg Ala Lys 
    210                 215                 220                 


Arg Asn Ser Arg Gln Phe Val Ala Ala Leu Ala Asp Leu Gln Glu Ala 
225                 230                 235                 240 


Val Lys Leu Cys Pro Thr Asn Gln Glu Val Lys Arg Leu Leu Ala Arg 
                245                 250                 255     


Val Glu Glu Glu Cys Lys Gln Leu Gln Arg Ser Gln Gln Gln Lys Gln 
            260                 265                 270         


Gln Gly Pro Leu Pro Ala Pro Leu Asn Asp Ser Glu Asn Glu Glu Asp 
        275                 280                 285             


Thr Pro Thr Pro Gly Leu Ser Asp His Phe His Ser Glu Glu Thr Glu 
    290                 295                 300                 


Glu Glu Glu Thr Ser Pro Gln Glu Glu Ser Val Ser Pro Thr Pro Arg 
305                 310                 315                 320 


Ser Gln Pro Ser Ser Ser Val Pro Ser Ser Tyr Ile Arg Asn Leu Gln 
                325                 330                 335     


Glu Gly Leu Gln Ser Lys Gly Arg Pro Val Ser Pro Gln Ser Arg Ala 
            340                 345                 350         


Gly Ile Gly Lys Ser Leu Arg Glu Pro Val Ala Gln Pro Gly Leu Leu 
        355                 360                 365             


Leu Gln Pro Ser Lys Gln Ala Gln Ile Val Lys Thr Ser Gln His Leu 
    370                 375                 380                 


Gly Ser Gly Gln Ser Ala Val Arg Asn Gly Ser Met Lys Val Gln Ile 
385                 390                 395                 400 


Ser Ser Gln Asn Pro Pro Pro Ser Pro Met Pro Gly Arg Ile Ala Ala 
                405                 410                 415     


Thr Pro Ala Gly Ser Arg Thr Gln His Leu Glu Gly Thr Gly Thr Phe 
            420                 425                 430         


Thr Thr Arg Ala Gly Cys Gly His Phe Gly Asp Arg Leu Gly Pro Ser 
        435                 440                 445             


Gln Asn Val Arg Leu Gln Cys Gly Glu Asn Gly Pro Ala His Pro Leu 
    450                 455                 460                 


Pro Ser Lys Thr Lys Thr Thr Glu Arg Leu Leu Ser His Ser Ser Val 
465                 470                 475                 480 


Ala Val Asp Ala Ala Pro Pro Asn Gln Gly Gly Leu Ala Thr Cys Ser 
                485                 490                 495     


Asp Val Arg His Pro Ala Ser Leu Thr Ser Ser Gly Ser Ser Gly Ser 
            500                 505                 510         


Pro Ser Ser Ser Ile Lys Met Ser Ser Ser Thr Ser Ser Leu Thr Ser 
        515                 520                 525             


Ser Ser Ser Phe Ser Asp Gly Phe Lys Val Gln Gly Pro Asp Thr Arg 
    530                 535                 540                 


Ile Lys Asp Lys Val Val Thr His Val Gln Ser Gly Thr Ala Glu His 
545                 550                 555                 560 


Arg Pro Arg Asn Thr Pro Phe Met Gly Ile Met Asp Lys Thr Ala Arg 
                565                 570                 575     


Phe Gln Gln Gln Ser Asn Pro Pro Ser Arg Ser Trp His Cys Pro Ala 
            580                 585                 590         


Pro Glu Gly Leu Leu Thr Asn Thr Ser Ser Ala Ala Gly Leu Gln Ser 
        595                 600                 605             


Ala Asn Thr Glu Lys Pro Ser Leu Met Gln Val Gly Gly Tyr Asn Asn 
    610                 615                 620                 


Gln Ala Lys Thr Cys Ser Val Ser Thr Leu Ser Ala Ser Val His Asn 
625                 630                 635                 640 


Gly Ala Gln Val Lys Glu Leu Glu Glu Ser Lys Cys Gln Ile Pro Val 
                645                 650                 655     


His Ser Gln Glu Asn Arg Ile Thr Lys Thr Val Ser His Leu Tyr Gln 
            660                 665                 670         


Glu Ser Ile Ser Lys Gln Gln Pro His Ile Ser Asn Glu Ala His Arg 
        675                 680                 685             


Ser His Leu Thr Ala Ala Lys Pro Lys Arg Ser Phe Ile Glu Ser Asn 
    690                 695                 700                 


Val 
705 


<210>  8539
<211>  5575
<212>  DNA
<213>  Homosapiens

<400>  8539
gctgtggcag ctgctggagc ggcggccgcc tcgggagccg gaggagaggc agccgcggag     60

cgccgagctg gcctcgcccc gaggcccggc cctgggtgtg gggaaccgcg ctgaggagct    120

ggaaactttc ccggcaggag ctgactgctg ggcaggaacg tctctcagga gaaagagtgg    180

aagagaaaat tgtgaactaa ggccccctgc ccccttttcc tggtgcatgt gaagttatca    240

aaaacagaaa caagtgttga aaatgttaaa ggctgtgctg aagaagagcc gagagggagg    300

aaagggaggc aagaaggaag caggaagtga ctttggtcca gagacttctc cagtcctgca    360

ccttgaccac agtgctgact ctcctgtgag cagtcttccc acagcagagg acacctatag    420

ggtgagcttg gccaaaggtg tctcgatgtc tctgccttcc tcacctttgc tgcctcgaca    480

gtctcacttg gtgcaatcaa gagtgaacaa aaaatcccca ggtcccgtca ggaagcccaa    540

gtatgtggaa agccccagag tgcctggaga tgcagttata atgccattca gagaagtagc    600

caagccaaca gagcctgatg agcatgaagc aaaggccgat aatgaaccga gctgttcgcc    660

ggcagctcaa gaactgttga caaggctggg atttttactg ggagaaggga tcccaagtgc    720

cacacacata accattgaag acaaaaatga aaccatgtgc acagctctga gtcaaggcat    780

cagtccttgc tccacactaa caagcagcac cgcatctcct agcaccgata gcccctgctc    840

aaccttgaat agctgtgtca gcaagacggc agccaacaaa agtccctgtg agaccattag    900

cagccctagt tccaccctgg aaagcaagga cagtggaatt atagccacaa ttacaagttc    960

atccgaaaat gatgaccgga gtggctccag tttggaatgg aataaagatg gagaaggaac   1020

atgaagtaga agtcaatggc accgacacat tgtggggaga aacagccctg actgccgccg   1080

caggaagagg gaagctggag gtctgtgagc tgctgctggg gcatggagct gctgtgtcgc   1140

ggacaaacag gagaggggtt ccacctttgt tttgtgcagc acgccagggg cattggcaga   1200

ttgttagact gctgttggaa cgcggctgtg atgtgaacct aagtgacaag caaggccgga   1260

cgcccctcat ggtggctgct tgtgaagggc acttgagcac cgtggaattc ctcctttcaa   1320

aaggtagcag cgtgatgccc tcaaaggttt cttttggacg gacacagaga gaacttcagc   1380

agacccattc agtgctttct gattcaaatt ctaagttttc tgttaatgga aattttctaa   1440

taaacagtag agagaatagg caacacagcc acatgcctgg tattcctctt cagcagcgat   1500

gaccattctg ccagcccatc cggccagtgt cacccttcac agtgcttgac tgacacttgg   1560

ttcaggccgg gtgttccgca ggtgtgaaac aatttgcttt ctggctttgt catctcataa   1620

tgttcatgtt ctgtgaatgg gctttccttt caggtgcagc cctttcttct ctagacaaag   1680

agggtctgtc agcattaagc tgggcttgtc tgaaaggtca cagggcagtg gtccagtatc   1740

tggttgaaga aggagctgca atagaccaga cagacaagaa tggccgcaca cccttggacc   1800

tggctgcctt ctatggcgat gccgagactg tgctgtacct ggtggagaag ggagccgtga   1860

tcgagcatgt ggaccacagc gggatgcggc ccttggacag agccatcggc tgccggaaca   1920

catctgtagt ggtggcgcta ctcagaaagg gagccaagtt aggaaatgct gcttgggcga   1980

tggccacttc caaacctgat atcttgatta tacttttaca gaaattaatg gaggaaggaa   2040

atgtgatgta caaaaaaggg aaaatgaaag aggcagccca gaggtaccag tatgccttaa   2100

gaaagtttcc tcgagaagga ttcggagagg acatgagacc cttcaatgaa ttaagggttt   2160

ccctctatct caatttgtcg cgatgccgaa gaaaaacaaa tgactttggc atggcagagg   2220

aatttgcttc caaggctctc gaattgaagc ccaagtccta tgaagccttt tatgccagag   2280

caagagcgaa gagaaatagc aggcaattcg tggcagctct ggctgacctg caagaggctg   2340

tgaaactctg tcccaccaat caggaagtca agaggcttct ggcccgcgta gaagaggagt   2400

gcaaacaact ccagaggagt caacagcaaa aacagcaggg cccgctacca gctccactca   2460

acgactccga gaacgaagag gacaccccaa cccctggctt aagtgaccac tttcactctg   2520

aggagactga agaggaagaa acttctcccc aggaagaatc tgtttcccca actcccaggt   2580

cccagccatc ctcatctgtc ccttcctcat acatccgaaa ccttcaagaa gggttacagt   2640

ccaaaggaag gccggtatcg ccacagagca gggcaggaat cggcaagtcc ctgagagagc   2700

ctgtggccca gccagggctg ctcctgcagc cctccaagca ggcccagatc gtgaaaacca   2760

gccagcacct gggctctggc cagtcggcag tgagaaatgg cagtatgaaa gttcagatct   2820

cttctcagaa ccctcctcca agtcccatgc cagggagaat cgctgccact cctgctggga   2880

gcagaaccca gcatttagag ggaacaggta ctttcactac aagagctggt tgtggccact   2940

ttggggatcg gctgggcccc agccagaatg tccgcctgca gtgtggtgag aatggccctg   3000

cacacccttt accaagtaag acgaaaacca cagagaggct tctgtctcat tcctccgtgg   3060

ctgtggacgc agcccctcca aaccaaggtg ggctggcgac ctgcagcgac gtgcgacacc   3120

cagcttccct caccagctca ggctcttctg gttctccatc cagcagcata aagatgtcaa   3180

gttcaaccag tagtttgact tcgagcagca gtttttcaga tggcttcaag gtccaaggac   3240

cagatactag aattaaagac aaggttgtaa cccacgttca gagcggtaca gctgagcaca   3300

gaccccgcaa cacgccgttc atgggcatca tggataagac tgcgaggttc caacagcaga   3360

gcaatcctcc aagccgcagc tggcactgtc cggcaccaga ggggctgctg acaaacacgt   3420

cttctgcagc tggcctgcag tctgctaaca ctgagaagcc ctctctcatg caagtgggag   3480

gatataataa ccaagccaaa acctgttctg tttctaccct gagtgcaagt gtccacaatg   3540

gggcacaagt gaaggagcta gaagaaagca agtgccaaat tccagtccac tctcaagaga   3600

acaggataac taagactgtt tctcatctgt accaggaaag tatctccaaa cagcagcctc   3660

atattagtaa tgaagcccac aggagccacc tcactgcagc caaaccaaag cgatcattta   3720

tagagtcaaa tgtgtgaacc ttaagaaatc cccatttgtg gaatttggaa acgtgtgttg   3780

actcctggtg gtaaattaaa tagttttttt catcagaaaa attatttttt agccattttt   3840

tttctttggg gtggatctga tgccattgat atatctaaaa tgtgggataa aacttcttta   3900

atagctagaa atcaccataa ataagaatgc taaacagaat tgaaaattat atcaacttaa   3960

aattttaaga cagcccagaa gacattaatg actctcactt atgaaattgt ttggcttttg   4020

ccactttctt ccttgccttt gctatatggt agaatcacag aacttactta gagaataaat   4080

atgtctattg ttcaagagta acaggtttaa ctcatgacca agtgatgtac atccaagtga   4140

tgtattctgg aaacgatgga attttacagt tacagttcca ttgagtcaaa tcccatttta   4200

tatatacata aaaattaagt tctgagtgag ttctagctaa atataagtgc gactgtaaac   4260

gcagccaatt tttttaagca gaatatgaga acacctaagt attctcttca tagcagttcc   4320

tataaaggga ttaaacactt atttctgtgt tatggttctt attcatatat ttttatagca   4380

cttttggaac ctatatttgt gcttgaaggt gtttttgata tttggaaaca gtataagcca   4440

tttggagtca tgattggtgg tcaagtggat tcaagctaaa atactaagac cagcattctt   4500

agtggcgctt ataaattagc tctcacctgg tttccaaact gcttttaaca atggtagtgc   4560

tcctggaaca atccttccaa gctcctctaa ggacaatatt taattcagat actaaaggta   4620

agactggttg ttacttttgt tttgttgtac aattagtact ttatagtcac atgttgtata   4680

tattaaatag cccagtttta ttcagacttg taaatagaac tatttcaatg tagttaatct   4740

aaaaacaaaa aagaaaaccc cagtcacgat ttgcatgttc tctgtaagct tcatccatgc   4800

tggttattgc actgaatgat atattattag ggcatgttaa cagtatacca gtaacagcac   4860

tttatctcat ttatatgaac acctttgagg tgctacttaa gtccaagctc tgatgtatta   4920

ttcatttgta aagataaggt acaggaatga accttggttt aaaggtattt ttatatgaaa   4980

atggtgtgtt attggaagat gttaaaatgc taatttgaga gaagtaggag tgtatctgtt   5040

ttatatgttg ggatgtgaaa tttattttct aaaattgagg agaaggaagt tatatatttg   5100

cagaatgttt taaagtgaat tgttgtaatg aagttcctgt gaacatcatt atggttttgt   5160

acaaatagga acctctgatg tcattcttca acgtttgttc ctgtgtgtac aattgtactt   5220

tgtatgaaca gctttatcat ttttataggc tttccatgag ttttgctgta actactatgg   5280

cttatttatt ttctttaata tttgtgaaag tcttactcct ttgttagttt tgtttctgca   5340

caactactgt acttttccat atggaataaa gactattaat agaatgtgtt ttgcactaaa   5400

tgagtcaatg gataagtaga gaacagcctg atgacagcta tctctgttgc ttttaatctt   5460

tgttacccta gagggaatag tgaaaagcat attttatatt aacactacaa aatgcttatt   5520

taatttcgtt ttataatttc agaataaggg tgacagctgc tagaaattcc acaat        5575


<210>  8540
<211>  705
<212>  PRT
<213>  Homosapiens

<400>  8540

Met Phe Met Phe Cys Glu Trp Ala Phe Leu Ser Gly Ala Ala Leu Ser 
1               5                   10                  15      


Ser Leu Asp Lys Glu Gly Leu Ser Ala Leu Ser Trp Ala Cys Leu Lys 
            20                  25                  30          


Gly His Arg Ala Val Val Gln Tyr Leu Val Glu Glu Gly Ala Ala Ile 
        35                  40                  45              


Asp Gln Thr Asp Lys Asn Gly Arg Thr Pro Leu Asp Leu Ala Ala Phe 
    50                  55                  60                  


Tyr Gly Asp Ala Glu Thr Val Leu Tyr Leu Val Glu Lys Gly Ala Val 
65                  70                  75                  80  


Ile Glu His Val Asp His Ser Gly Met Arg Pro Leu Asp Arg Ala Ile 
                85                  90                  95      


Gly Cys Arg Asn Thr Ser Val Val Val Ala Leu Leu Arg Lys Gly Ala 
            100                 105                 110         


Lys Leu Gly Asn Ala Ala Trp Ala Met Ala Thr Ser Lys Pro Asp Ile 
        115                 120                 125             


Leu Ile Ile Leu Leu Gln Lys Leu Met Glu Glu Gly Asn Val Met Tyr 
    130                 135                 140                 


Lys Lys Gly Lys Met Lys Glu Ala Ala Gln Arg Tyr Gln Tyr Ala Leu 
145                 150                 155                 160 


Arg Lys Phe Pro Arg Glu Gly Phe Gly Glu Asp Met Arg Pro Phe Asn 
                165                 170                 175     


Glu Leu Arg Val Ser Leu Tyr Leu Asn Leu Ser Arg Cys Arg Arg Lys 
            180                 185                 190         


Thr Asn Asp Phe Gly Met Ala Glu Glu Phe Ala Ser Lys Ala Leu Glu 
        195                 200                 205             


Leu Lys Pro Lys Ser Tyr Glu Ala Phe Tyr Ala Arg Ala Arg Ala Lys 
    210                 215                 220                 


Arg Asn Ser Arg Gln Phe Val Ala Ala Leu Ala Asp Leu Gln Glu Ala 
225                 230                 235                 240 


Val Lys Leu Cys Pro Thr Asn Gln Glu Val Lys Arg Leu Leu Ala Arg 
                245                 250                 255     


Val Glu Glu Glu Cys Lys Gln Leu Gln Arg Ser Gln Gln Gln Lys Gln 
            260                 265                 270         


Gln Gly Pro Leu Pro Ala Pro Leu Asn Asp Ser Glu Asn Glu Glu Asp 
        275                 280                 285             


Thr Pro Thr Pro Gly Leu Ser Asp His Phe His Ser Glu Glu Thr Glu 
    290                 295                 300                 


Glu Glu Glu Thr Ser Pro Gln Glu Glu Ser Val Ser Pro Thr Pro Arg 
305                 310                 315                 320 


Ser Gln Pro Ser Ser Ser Val Pro Ser Ser Tyr Ile Arg Asn Leu Gln 
                325                 330                 335     


Glu Gly Leu Gln Ser Lys Gly Arg Pro Val Ser Pro Gln Ser Arg Ala 
            340                 345                 350         


Gly Ile Gly Lys Ser Leu Arg Glu Pro Val Ala Gln Pro Gly Leu Leu 
        355                 360                 365             


Leu Gln Pro Ser Lys Gln Ala Gln Ile Val Lys Thr Ser Gln His Leu 
    370                 375                 380                 


Gly Ser Gly Gln Ser Ala Val Arg Asn Gly Ser Met Lys Val Gln Ile 
385                 390                 395                 400 


Ser Ser Gln Asn Pro Pro Pro Ser Pro Met Pro Gly Arg Ile Ala Ala 
                405                 410                 415     


Thr Pro Ala Gly Ser Arg Thr Gln His Leu Glu Gly Thr Gly Thr Phe 
            420                 425                 430         


Thr Thr Arg Ala Gly Cys Gly His Phe Gly Asp Arg Leu Gly Pro Ser 
        435                 440                 445             


Gln Asn Val Arg Leu Gln Cys Gly Glu Asn Gly Pro Ala His Pro Leu 
    450                 455                 460                 


Pro Ser Lys Thr Lys Thr Thr Glu Arg Leu Leu Ser His Ser Ser Val 
465                 470                 475                 480 


Ala Val Asp Ala Ala Pro Pro Asn Gln Gly Gly Leu Ala Thr Cys Ser 
                485                 490                 495     


Asp Val Arg His Pro Ala Ser Leu Thr Ser Ser Gly Ser Ser Gly Ser 
            500                 505                 510         


Pro Ser Ser Ser Ile Lys Met Ser Ser Ser Thr Ser Ser Leu Thr Ser 
        515                 520                 525             


Ser Ser Ser Phe Ser Asp Gly Phe Lys Val Gln Gly Pro Asp Thr Arg 
    530                 535                 540                 


Ile Lys Asp Lys Val Val Thr His Val Gln Ser Gly Thr Ala Glu His 
545                 550                 555                 560 


Arg Pro Arg Asn Thr Pro Phe Met Gly Ile Met Asp Lys Thr Ala Arg 
                565                 570                 575     


Phe Gln Gln Gln Ser Asn Pro Pro Ser Arg Ser Trp His Cys Pro Ala 
            580                 585                 590         


Pro Glu Gly Leu Leu Thr Asn Thr Ser Ser Ala Ala Gly Leu Gln Ser 
        595                 600                 605             


Ala Asn Thr Glu Lys Pro Ser Leu Met Gln Val Gly Gly Tyr Asn Asn 
    610                 615                 620                 


Gln Ala Lys Thr Cys Ser Val Ser Thr Leu Ser Ala Ser Val His Asn 
625                 630                 635                 640 


Gly Ala Gln Val Lys Glu Leu Glu Glu Ser Lys Cys Gln Ile Pro Val 
                645                 650                 655     


His Ser Gln Glu Asn Arg Ile Thr Lys Thr Val Ser His Leu Tyr Gln 
            660                 665                 670         


Glu Ser Ile Ser Lys Gln Gln Pro His Ile Ser Asn Glu Ala His Arg 
        675                 680                 685             


Ser His Leu Thr Ala Ala Lys Pro Lys Arg Ser Phe Ile Glu Ser Asn 
    690                 695                 700                 


Val 
705 


<210>  8541
<211>  7462
<212>  DNA
<213>  Homosapiens

<400>  8541
gacagaaaca gggaaaatac ttgtaagtag gagtcatgga aggcaagagg ataagtgaga     60

agcaggtcat ggatagatag aggcagagga ttaatgtcaa accaagggcc tgtctcattt    120

agcagactag attcacaagt gctatcttgg acacttggta ttaagtcaac ttcgaggtca    180

catggtgata ggtcacatga tagtgaactg acgaatgtcg tcagcaatac tcagtgttct    240

ttagagtctg aggaggacga gaatggagga aagacttctc tatggagtga taatacttgg    300

tgatcactag ggacctgcgc tcctcccctg gctttaaaca agagagaatg attggaatgg    360

aaaatgaaag cagtaaggtg caggccaaat tgggatggtt tgaagcaaag gccgataatg    420

aaccgagctg ttcgccggca gctcaagaac tgttgacaag gctgggattt ttactgggag    480

aagggatccc aagtgccaca cacataacca ttgaagacaa aaatgaaacc atgtgcacag    540

ctctgagtca aggcatcagt ccttgctcca cactaacaag cagcaccgca tctcctagca    600

ccgatagccc ctgctcaacc ttgaatagct gtgtcagcaa gacggcagcc aacaaaagtc    660

cctgtgagac cattagcagc cctagttcca ccctggaaag caaggacagt ggaattatag    720

ccacaattac aagttcatcc gaaaatgatg accggagtgg ctccagtttg gaatggaata    780

aagatggaaa cctaagatta ggggttcaga agggagtgct tcatgaccgc agggcagata    840

actgctcccc agtggcagaa gaggagacca ccgggtcagc agagagcacg ctgcccaaag    900

cagaatcctc agctggagat ggtccagtcc cttattctca gggctccagc tcactaataa    960

tgccacggcc caactcagtt gcagcaacaa gctcaaccaa attggaagat ctgagttatt   1020

tagacgggca gagaaatgct cctctacgga cgtcaattag attaccatgg cacaatacgg   1080

ccggaggtag ggcacaggaa gttaaagcac gatttgctcc ctacaagcca caagacattt   1140

tgttgaaacc cttgttgttt gaagtaccaa gcataacaac agactctgtg tttgtgggaa   1200

gggattggct ctttcaccag atagaagaaa acttgaggaa cacagaactg gcagaaaaca   1260

gaggcgcggt ggtggttggc aatgtgggat ttgggaagac ggcaatcatt tccaagttgg   1320

tggccctgag ctgccacgga agccgcatga ggcagattgc ttccaacagc ccgggttcat   1380

cacctaaaac ctctgacccc actcaggatc ttcatttcac tccgttgctt tcaccgagtt   1440

cttccacaag tgcttccagc acagctaaaa cacctcttgg gtctatcagt gctgaaaacc   1500

agagaccaag agaggatgca gtgaaatatc ttgcttctaa ggtggtggcc taccactact   1560

gccaggctga caacacgtac acttgcctgg tgcccgagtt tgtgcacagc atcgcagctt   1620

tgctctgccg gtcccatcag ctggccgcct acagagacct tctgataaag gagccccaac   1680

tacagagcat gctgagcctc cgatcctgtg tgcaggaccc ggtggcagct ttcaagaggg   1740

gagtgctgga gccactcaca aacctgagaa atgagcagaa aattcctgaa gaagaataca   1800

ttattttgat agatggctta aatgaagctg agtttcataa acctgattat ggagatacgc   1860

tttcttcatt tattaccaaa attatttcta aatttcctgc ctggttgaag ttgattgtga   1920

ctgtaagagc aaattttcag gaaatcataa gtgcgctgcc atttgtcaag ctttccttag   1980

atgacttccc agacaacaaa gacatccaca gtgacctgca cgcctacgtc cagcacaggg   2040

tgcacagcag ccaggacatc ctcagcaaca tctccctgaa tggcaaggcc gatgccacac   2100

tcattggaaa agtgagcagc cacctggtgc tgcggagcct cggctcctac ctgtacctca   2160

agctcaccct ggaccttttc cagaggggcc acttggtcat taagagtgcc agctacaagg   2220

tggtgcccgt gtctctctct gagctctatt tgcttcagtg caacatgaag ttcatgaccc   2280

agtccgcctt tgagagggca cttccgattc tcaacgtggc cctcgcatcc ctccacccca   2340

tgacagacga gcagatcttt caggctatta atgctggcca catccagggg gagcagggat   2400

gggaagactt tcagcagagg atggacgccc tctcctgctt cctcattaag aggcgagaca   2460

aaacccgcat gttctgccac ccgtccttca gggagtggct tgtatggaga gcagacgggg   2520

aaaacacggc cttcctgtgt gagcccagga acgggcacgc gctcttggca ttcatgttct   2580

cgcgtcagga gggcaagttg aaccgccagc agaccatgga gcttggccac cacatcctga   2640

aggcgcacat tttcaagggc ctcagtaaga agacgggaat ttcttcaagc catctccaag   2700

ccctgtggat cggctacagc accgaggggc tgtccgccgc cctggcctct ctcaggaatc   2760

tctatactcc caacgtgaag gtgagccgtc tcctgatttt gggaggggcc aacgtgaact   2820

acaggacaga agtgttaaat aatgccccaa tcctgtgcgt ccagtctcac cttggccacg   2880

aggaagttgt cactctgctc ctggaatttg gtgcctgcct ggacggaacg tcagagaacg   2940

gcatgactgc cctctgttac gcagcagctg ctggccacat gaagctggtg tgtctgctga   3000

ccaagaaggg agtgagagtg gaccacttgg ataagaaggg ccagtgtgcg cttgtccaca   3060

gtgccctacg gggccacggt gacattctcc agtacctgct gacttgtgag tggtcgccgg   3120

gtcctcccca gccaggcacc ctgaggaaga gccacgccct gcagcaggcg ctgaccgcgg   3180

cggccagcat gggccacagc tcggtggtcc agtgcttgct ggggatggag aaggaacatg   3240

aagtagaagt caatggcacc gacacattgt ggggagaaac agccctgact gccgccgcag   3300

gaagagggaa gctggaggtc tgtgagctgc tgctggggca tggagctgct gtgtcgcgga   3360

caaacaggag aggggttcca cctttgtttt gtgcagcacg ccaggggcat tggcagattg   3420

ttagactgct gttggaacgc ggctgtgatg tgaacctaag tgacaagcaa ggccggacgc   3480

ccctcatggt ggctgcttgt gaagggcact tgagcaccgt ggaattcctc ctttcaaaag   3540

gtgcagccct ttcttctcta gacaaagagg gtctgtcagc attaagctgg gcttgtctga   3600

aaggtcacag ggcagtggtc cagtatctgg ttgaagaagg agctgcaata gaccagacag   3660

acaagaatgg ccgcacaccc ttggacctgg ctgccttcta tggcgatgcc gagactgtgc   3720

tgtacctggt ggagaaggga gccgtgatcg agcatgtgga ccacagcggg atgcggccct   3780

tggacagagc catcggctgc cggaacacat ctgtagtggt ggcgctactc agaaagggag   3840

ccaagttagg aaatgctgct tgggcgatgg ccacttccaa acctgatatc ttgattatac   3900

ttttacagaa attaatggag gaaggaaatg tgatgtacaa aaaagggaaa atgaaagagg   3960

cagcccagag gtaccagtat gccttaagaa agtttcctcg agaaggattc ggagaggaca   4020

tgagaccctt caatgaatta agggtttccc tctatctcaa tttgtcgcga tgccgaagaa   4080

aaacaaatga ctttggcatg gcagaggaat ttgcttccaa ggctctcgaa ttgaagccca   4140

agtcctatga agccttttat gccagagcaa gagcgaagag aaatagcagg caattcgtgg   4200

cagctctggc tgacctgcaa gaggctgtga aactctgtcc caccaatcag gaagtcaaga   4260

ggcttctggc ccgcgtagaa gaggagtgca aacaactcca gaggagtcaa cagcaaaaac   4320

agcagggccc gctaccagct ccactcaacg actccgagaa cgaagaggac accccaaccc   4380

ctggcttaag tgaccacttt cactctgagg agactgaaga ggaagaaact tctccccagg   4440

aagaatctgt ttccccaact cccaggtccc agccatcctc atctgtccct tcctcataca   4500

tccgaaacct tcaagaaggg ttacagtcca aaggaaggcc ggtatcgcca cagagcaggg   4560

caggaatcgg caagtccctg agagagcctg tggcccagcc agggctgctc ctgcagccct   4620

ccaagcaggc ccagatcgtg aaaaccagcc agcacctggg ctctggccag tcggcagtga   4680

gaaatggcag tatgaaagtt cagatctctt ctcagaaccc tcctccaagt cccatgccag   4740

ggagaatcgc tgccactcct gctgggagca gaacccagca tttagaggga acaggtactt   4800

tcactacaag agctggttgt ggccactttg gggatcggct gggccccagc cagaatgtcc   4860

gcctgcagtg tggtgagaat ggccctgcac accctttacc aagtaagacg aaaaccacag   4920

agaggcttct gtctcattcc tccgtggctg tggacgcagc ccctccaaac caaggtgggc   4980

tggcgacctg cagcgacgtg cgacacccag cttccctcac cagctcaggc tcttctggtt   5040

ctccatccag cagcataaag atgtcaagtt caaccagtag tttgacttcg agcagcagtt   5100

tttcagatgg cttcaaggtc caaggaccag atactagaat taaagacaag gttgtaaccc   5160

acgttcagag cggtacagct gagcacagac cccgcaacac gccgttcatg ggcatcatgg   5220

ataagactgc gaggttccaa cagcagagca atcctccaag ccgcagctgg cactgtccgg   5280

caccagaggg gctgctgaca aacacgtctt ctgcagctgg cctgcagtct gctaacactg   5340

agaagccctc tctcatgcaa gtgggaggat ataataacca agccaaaacc tgttctgttt   5400

ctaccctgag tgcaagtgtc cacaatgggg cacaagtgaa ggagctagaa gaaagcaagt   5460

gccaaattcc agtccactct caagagaaca ggataactaa gactgtttct catctgtacc   5520

aggaaagtat ctccaaacag cagcctcata ttagtaatga agcccacagg agccacctca   5580

ctgcagccaa accaaagcga tcatttatag agtcaaatgt gtgaacctta agaaatcccc   5640

atttgtggaa tttggaaacg tgtgttgact cctggtggta aattaaatag tttttttcat   5700

cagaaaaatt attttttagc catttttttt ctttggggtg gatctgatgc cattgatata   5760

tctaaaatgt gggataaaac ttctttaata gctagaaatc accataaata agaatgctaa   5820

acagaattga aaattatatc aacttaaaat tttaagacag cccagaagac attaatgact   5880

ctcacttatg aaattgtttg gcttttgcca ctttcttcct tgcctttgct atatggtaga   5940

atcacagaac ttacttagag aataaatatg tctattgttc aagagtaaca ggtttaactc   6000

atgaccaagt gatgtacatc caagtgatgt attctggaaa cgatggaatt ttacagttac   6060

agttccattg agtcaaatcc cattttatat atacataaaa attaagttct gagtgagttc   6120

tagctaaata taagtgcgac tgtaaacgca gccaattttt ttaagcagaa tatgagaaca   6180

cctaagtatt ctcttcatag cagttcctat aaagggatta aacacttatt tctgtgttat   6240

ggttcttatt catatatttt tatagcactt ttggaaccta tatttgtgct tgaaggtgtt   6300

tttgatattt ggaaacagta taagccattt ggagtcatga ttggtggtca agtggattca   6360

agctaaaata ctaagaccag cattcttagt ggcgcttata aattagctct cacctggttt   6420

ccaaactgct tttaacaatg gtagtgctcc tggaacaatc cttccaagct cctctaagga   6480

caatatttaa ttcagatact aaaggtaaga ctggttgtta cttttgtttt gttgtacaat   6540

tagtacttta tagtcacatg ttgtatatat taaatagccc agttttattc agacttgtaa   6600

atagaactat ttcaatgtag ttaatctaaa aacaaaaaag aaaaccccag tcacgatttg   6660

catgttctct gtaagcttca tccatgctgg ttattgcact gaatgatata ttattagggc   6720

atgttaacag tataccagta acagcacttt atctcattta tatgaacacc tttgaggtgc   6780

tacttaagtc caagctctga tgtattattc atttgtaaag ataaggtaca ggaatgaacc   6840

ttggtttaaa ggtattttta tatgaaaatg gtgtgttatt ggaagatgtt aaaatgctaa   6900

tttgagagaa gtaggagtgt atctgtttta tatgttggga tgtgaaattt attttctaaa   6960

attgaggaga aggaagttat atatttgcag aatgttttaa agtgaattgt tgtaatgaag   7020

ttcctgtgaa catcattatg gttttgtaca aataggaacc tctgatgtca ttcttcaacg   7080

tttgttcctg tgtgtacaat tgtactttgt atgaacagct ttatcatttt tataggcttt   7140

ccatgagttt tgctgtaact actatggctt atttattttc tttaatattt gtgaaagtct   7200

tactcctttg ttagttttgt ttctgcacaa ctactgtact tttccatatg gaataaagac   7260

tattaataga atgtgttttg cactaaatga gtcaatggat aagtagagaa cagcctgatg   7320

acagctatct ctgttgcttt taatctttgt taccctagag ggaatagtga aaagcatatt   7380

ttatattaac actacaaaat gcttatttaa tttcgtttta taatttcaga ataagggtga   7440

cagctgctag aaattccaca at                                            7462


<210>  8542
<211>  1758
<212>  PRT
<213>  Homosapiens

<400>  8542

Met Ile Gly Met Glu Asn Glu Ser Ser Lys Val Gln Ala Lys Leu Gly 
1               5                   10                  15      


Trp Phe Glu Ala Lys Ala Asp Asn Glu Pro Ser Cys Ser Pro Ala Ala 
            20                  25                  30          


Gln Glu Leu Leu Thr Arg Leu Gly Phe Leu Leu Gly Glu Gly Ile Pro 
        35                  40                  45              


Ser Ala Thr His Ile Thr Ile Glu Asp Lys Asn Glu Thr Met Cys Thr 
    50                  55                  60                  


Ala Leu Ser Gln Gly Ile Ser Pro Cys Ser Thr Leu Thr Ser Ser Thr 
65                  70                  75                  80  


Ala Ser Pro Ser Thr Asp Ser Pro Cys Ser Thr Leu Asn Ser Cys Val 
                85                  90                  95      


Ser Lys Thr Ala Ala Asn Lys Ser Pro Cys Glu Thr Ile Ser Ser Pro 
            100                 105                 110         


Ser Ser Thr Leu Glu Ser Lys Asp Ser Gly Ile Ile Ala Thr Ile Thr 
        115                 120                 125             


Ser Ser Ser Glu Asn Asp Asp Arg Ser Gly Ser Ser Leu Glu Trp Asn 
    130                 135                 140                 


Lys Asp Gly Asn Leu Arg Leu Gly Val Gln Lys Gly Val Leu His Asp 
145                 150                 155                 160 


Arg Arg Ala Asp Asn Cys Ser Pro Val Ala Glu Glu Glu Thr Thr Gly 
                165                 170                 175     


Ser Ala Glu Ser Thr Leu Pro Lys Ala Glu Ser Ser Ala Gly Asp Gly 
            180                 185                 190         


Pro Val Pro Tyr Ser Gln Gly Ser Ser Ser Leu Ile Met Pro Arg Pro 
        195                 200                 205             


Asn Ser Val Ala Ala Thr Ser Ser Thr Lys Leu Glu Asp Leu Ser Tyr 
    210                 215                 220                 


Leu Asp Gly Gln Arg Asn Ala Pro Leu Arg Thr Ser Ile Arg Leu Pro 
225                 230                 235                 240 


Trp His Asn Thr Ala Gly Gly Arg Ala Gln Glu Val Lys Ala Arg Phe 
                245                 250                 255     


Ala Pro Tyr Lys Pro Gln Asp Ile Leu Leu Lys Pro Leu Leu Phe Glu 
            260                 265                 270         


Val Pro Ser Ile Thr Thr Asp Ser Val Phe Val Gly Arg Asp Trp Leu 
        275                 280                 285             


Phe His Gln Ile Glu Glu Asn Leu Arg Asn Thr Glu Leu Ala Glu Asn 
    290                 295                 300                 


Arg Gly Ala Val Val Val Gly Asn Val Gly Phe Gly Lys Thr Ala Ile 
305                 310                 315                 320 


Ile Ser Lys Leu Val Ala Leu Ser Cys His Gly Ser Arg Met Arg Gln 
                325                 330                 335     


Ile Ala Ser Asn Ser Pro Gly Ser Ser Pro Lys Thr Ser Asp Pro Thr 
            340                 345                 350         


Gln Asp Leu His Phe Thr Pro Leu Leu Ser Pro Ser Ser Ser Thr Ser 
        355                 360                 365             


Ala Ser Ser Thr Ala Lys Thr Pro Leu Gly Ser Ile Ser Ala Glu Asn 
    370                 375                 380                 


Gln Arg Pro Arg Glu Asp Ala Val Lys Tyr Leu Ala Ser Lys Val Val 
385                 390                 395                 400 


Ala Tyr His Tyr Cys Gln Ala Asp Asn Thr Tyr Thr Cys Leu Val Pro 
                405                 410                 415     


Glu Phe Val His Ser Ile Ala Ala Leu Leu Cys Arg Ser His Gln Leu 
            420                 425                 430         


Ala Ala Tyr Arg Asp Leu Leu Ile Lys Glu Pro Gln Leu Gln Ser Met 
        435                 440                 445             


Leu Ser Leu Arg Ser Cys Val Gln Asp Pro Val Ala Ala Phe Lys Arg 
    450                 455                 460                 


Gly Val Leu Glu Pro Leu Thr Asn Leu Arg Asn Glu Gln Lys Ile Pro 
465                 470                 475                 480 


Glu Glu Glu Tyr Ile Ile Leu Ile Asp Gly Leu Asn Glu Ala Glu Phe 
                485                 490                 495     


His Lys Pro Asp Tyr Gly Asp Thr Leu Ser Ser Phe Ile Thr Lys Ile 
            500                 505                 510         


Ile Ser Lys Phe Pro Ala Trp Leu Lys Leu Ile Val Thr Val Arg Ala 
        515                 520                 525             


Asn Phe Gln Glu Ile Ile Ser Ala Leu Pro Phe Val Lys Leu Ser Leu 
    530                 535                 540                 


Asp Asp Phe Pro Asp Asn Lys Asp Ile His Ser Asp Leu His Ala Tyr 
545                 550                 555                 560 


Val Gln His Arg Val His Ser Ser Gln Asp Ile Leu Ser Asn Ile Ser 
                565                 570                 575     


Leu Asn Gly Lys Ala Asp Ala Thr Leu Ile Gly Lys Val Ser Ser His 
            580                 585                 590         


Leu Val Leu Arg Ser Leu Gly Ser Tyr Leu Tyr Leu Lys Leu Thr Leu 
        595                 600                 605             


Asp Leu Phe Gln Arg Gly His Leu Val Ile Lys Ser Ala Ser Tyr Lys 
    610                 615                 620                 


Val Val Pro Val Ser Leu Ser Glu Leu Tyr Leu Leu Gln Cys Asn Met 
625                 630                 635                 640 


Lys Phe Met Thr Gln Ser Ala Phe Glu Arg Ala Leu Pro Ile Leu Asn 
                645                 650                 655     


Val Ala Leu Ala Ser Leu His Pro Met Thr Asp Glu Gln Ile Phe Gln 
            660                 665                 670         


Ala Ile Asn Ala Gly His Ile Gln Gly Glu Gln Gly Trp Glu Asp Phe 
        675                 680                 685             


Gln Gln Arg Met Asp Ala Leu Ser Cys Phe Leu Ile Lys Arg Arg Asp 
    690                 695                 700                 


Lys Thr Arg Met Phe Cys His Pro Ser Phe Arg Glu Trp Leu Val Trp 
705                 710                 715                 720 


Arg Ala Asp Gly Glu Asn Thr Ala Phe Leu Cys Glu Pro Arg Asn Gly 
                725                 730                 735     


His Ala Leu Leu Ala Phe Met Phe Ser Arg Gln Glu Gly Lys Leu Asn 
            740                 745                 750         


Arg Gln Gln Thr Met Glu Leu Gly His His Ile Leu Lys Ala His Ile 
        755                 760                 765             


Phe Lys Gly Leu Ser Lys Lys Thr Gly Ile Ser Ser Ser His Leu Gln 
    770                 775                 780                 


Ala Leu Trp Ile Gly Tyr Ser Thr Glu Gly Leu Ser Ala Ala Leu Ala 
785                 790                 795                 800 


Ser Leu Arg Asn Leu Tyr Thr Pro Asn Val Lys Val Ser Arg Leu Leu 
                805                 810                 815     


Ile Leu Gly Gly Ala Asn Val Asn Tyr Arg Thr Glu Val Leu Asn Asn 
            820                 825                 830         


Ala Pro Ile Leu Cys Val Gln Ser His Leu Gly His Glu Glu Val Val 
        835                 840                 845             


Thr Leu Leu Leu Glu Phe Gly Ala Cys Leu Asp Gly Thr Ser Glu Asn 
    850                 855                 860                 


Gly Met Thr Ala Leu Cys Tyr Ala Ala Ala Ala Gly His Met Lys Leu 
865                 870                 875                 880 


Val Cys Leu Leu Thr Lys Lys Gly Val Arg Val Asp His Leu Asp Lys 
                885                 890                 895     


Lys Gly Gln Cys Ala Leu Val His Ser Ala Leu Arg Gly His Gly Asp 
            900                 905                 910         


Ile Leu Gln Tyr Leu Leu Thr Cys Glu Trp Ser Pro Gly Pro Pro Gln 
        915                 920                 925             


Pro Gly Thr Leu Arg Lys Ser His Ala Leu Gln Gln Ala Leu Thr Ala 
    930                 935                 940                 


Ala Ala Ser Met Gly His Ser Ser Val Val Gln Cys Leu Leu Gly Met 
945                 950                 955                 960 


Glu Lys Glu His Glu Val Glu Val Asn Gly Thr Asp Thr Leu Trp Gly 
                965                 970                 975     


Glu Thr Ala Leu Thr Ala Ala Ala Gly Arg Gly Lys Leu Glu Val Cys 
            980                 985                 990         


Glu Leu Leu Leu Gly His Gly Ala  Ala Val Ser Arg Thr  Asn Arg Arg 
        995                 1000                 1005             


Gly Val  Pro Pro Leu Phe Cys  Ala Ala Arg Gln Gly  His Trp Gln 
    1010                 1015                 1020             


Ile Val  Arg Leu Leu Leu Glu  Arg Gly Cys Asp Val  Asn Leu Ser 
    1025                 1030                 1035             


Asp Lys  Gln Gly Arg Thr Pro  Leu Met Val Ala Ala  Cys Glu Gly 
    1040                 1045                 1050             


His Leu  Ser Thr Val Glu Phe  Leu Leu Ser Lys Gly  Ala Ala Leu 
    1055                 1060                 1065             


Ser Ser  Leu Asp Lys Glu Gly  Leu Ser Ala Leu Ser  Trp Ala Cys 
    1070                 1075                 1080             


Leu Lys  Gly His Arg Ala Val  Val Gln Tyr Leu Val  Glu Glu Gly 
    1085                 1090                 1095             


Ala Ala  Ile Asp Gln Thr Asp  Lys Asn Gly Arg Thr  Pro Leu Asp 
    1100                 1105                 1110             


Leu Ala  Ala Phe Tyr Gly Asp  Ala Glu Thr Val Leu  Tyr Leu Val 
    1115                 1120                 1125             


Glu Lys  Gly Ala Val Ile Glu  His Val Asp His Ser  Gly Met Arg 
    1130                 1135                 1140             


Pro Leu  Asp Arg Ala Ile Gly  Cys Arg Asn Thr Ser  Val Val Val 
    1145                 1150                 1155             


Ala Leu  Leu Arg Lys Gly Ala  Lys Leu Gly Asn Ala  Ala Trp Ala 
    1160                 1165                 1170             


Met Ala  Thr Ser Lys Pro Asp  Ile Leu Ile Ile Leu  Leu Gln Lys 
    1175                 1180                 1185             


Leu Met  Glu Glu Gly Asn Val  Met Tyr Lys Lys Gly  Lys Met Lys 
    1190                 1195                 1200             


Glu Ala  Ala Gln Arg Tyr Gln  Tyr Ala Leu Arg Lys  Phe Pro Arg 
    1205                 1210                 1215             


Glu Gly  Phe Gly Glu Asp Met  Arg Pro Phe Asn Glu  Leu Arg Val 
    1220                 1225                 1230             


Ser Leu  Tyr Leu Asn Leu Ser  Arg Cys Arg Arg Lys  Thr Asn Asp 
    1235                 1240                 1245             


Phe Gly  Met Ala Glu Glu Phe  Ala Ser Lys Ala Leu  Glu Leu Lys 
    1250                 1255                 1260             


Pro Lys  Ser Tyr Glu Ala Phe  Tyr Ala Arg Ala Arg  Ala Lys Arg 
    1265                 1270                 1275             


Asn Ser  Arg Gln Phe Val Ala  Ala Leu Ala Asp Leu  Gln Glu Ala 
    1280                 1285                 1290             


Val Lys  Leu Cys Pro Thr Asn  Gln Glu Val Lys Arg  Leu Leu Ala 
    1295                 1300                 1305             


Arg Val  Glu Glu Glu Cys Lys  Gln Leu Gln Arg Ser  Gln Gln Gln 
    1310                 1315                 1320             


Lys Gln  Gln Gly Pro Leu Pro  Ala Pro Leu Asn Asp  Ser Glu Asn 
    1325                 1330                 1335             


Glu Glu  Asp Thr Pro Thr Pro  Gly Leu Ser Asp His  Phe His Ser 
    1340                 1345                 1350             


Glu Glu  Thr Glu Glu Glu Glu  Thr Ser Pro Gln Glu  Glu Ser Val 
    1355                 1360                 1365             


Ser Pro  Thr Pro Arg Ser Gln  Pro Ser Ser Ser Val  Pro Ser Ser 
    1370                 1375                 1380             


Tyr Ile  Arg Asn Leu Gln Glu  Gly Leu Gln Ser Lys  Gly Arg Pro 
    1385                 1390                 1395             


Val Ser  Pro Gln Ser Arg Ala  Gly Ile Gly Lys Ser  Leu Arg Glu 
    1400                 1405                 1410             


Pro Val  Ala Gln Pro Gly Leu  Leu Leu Gln Pro Ser  Lys Gln Ala 
    1415                 1420                 1425             


Gln Ile  Val Lys Thr Ser Gln  His Leu Gly Ser Gly  Gln Ser Ala 
    1430                 1435                 1440             


Val Arg  Asn Gly Ser Met Lys  Val Gln Ile Ser Ser  Gln Asn Pro 
    1445                 1450                 1455             


Pro Pro  Ser Pro Met Pro Gly  Arg Ile Ala Ala Thr  Pro Ala Gly 
    1460                 1465                 1470             


Ser Arg  Thr Gln His Leu Glu  Gly Thr Gly Thr Phe  Thr Thr Arg 
    1475                 1480                 1485             


Ala Gly  Cys Gly His Phe Gly  Asp Arg Leu Gly Pro  Ser Gln Asn 
    1490                 1495                 1500             


Val Arg  Leu Gln Cys Gly Glu  Asn Gly Pro Ala His  Pro Leu Pro 
    1505                 1510                 1515             


Ser Lys  Thr Lys Thr Thr Glu  Arg Leu Leu Ser His  Ser Ser Val 
    1520                 1525                 1530             


Ala Val  Asp Ala Ala Pro Pro  Asn Gln Gly Gly Leu  Ala Thr Cys 
    1535                 1540                 1545             


Ser Asp  Val Arg His Pro Ala  Ser Leu Thr Ser Ser  Gly Ser Ser 
    1550                 1555                 1560             


Gly Ser  Pro Ser Ser Ser Ile  Lys Met Ser Ser Ser  Thr Ser Ser 
    1565                 1570                 1575             


Leu Thr  Ser Ser Ser Ser Phe  Ser Asp Gly Phe Lys  Val Gln Gly 
    1580                 1585                 1590             


Pro Asp  Thr Arg Ile Lys Asp  Lys Val Val Thr His  Val Gln Ser 
    1595                 1600                 1605             


Gly Thr  Ala Glu His Arg Pro  Arg Asn Thr Pro Phe  Met Gly Ile 
    1610                 1615                 1620             


Met Asp  Lys Thr Ala Arg Phe  Gln Gln Gln Ser Asn  Pro Pro Ser 
    1625                 1630                 1635             


Arg Ser  Trp His Cys Pro Ala  Pro Glu Gly Leu Leu  Thr Asn Thr 
    1640                 1645                 1650             


Ser Ser  Ala Ala Gly Leu Gln  Ser Ala Asn Thr Glu  Lys Pro Ser 
    1655                 1660                 1665             


Leu Met  Gln Val Gly Gly Tyr  Asn Asn Gln Ala Lys  Thr Cys Ser 
    1670                 1675                 1680             


Val Ser  Thr Leu Ser Ala Ser  Val His Asn Gly Ala  Gln Val Lys 
    1685                 1690                 1695             


Glu Leu  Glu Glu Ser Lys Cys  Gln Ile Pro Val His  Ser Gln Glu 
    1700                 1705                 1710             


Asn Arg  Ile Thr Lys Thr Val  Ser His Leu Tyr Gln  Glu Ser Ile 
    1715                 1720                 1725             


Ser Lys  Gln Gln Pro His Ile  Ser Asn Glu Ala His  Arg Ser His 
    1730                 1735                 1740             


Leu Thr  Ala Ala Lys Pro Lys  Arg Ser Phe Ile Glu  Ser Asn Val 
    1745                 1750                 1755             


<210>  8543
<211>  2141
<212>  DNA
<213>  Homosapiens

<400>  8543
caaaatgtgc tttgaggtag gaagggacct cctgtagagc ggctttggca tgaggtcgac     60

ccgccctggg gtggctcctt ttccctgtgt tggcttgggg ccactgcccc ttcatgtttg    120

gctcacatgg tccagaagca tcagggctct tttaacccag aatagtcaag ccttggtttc    180

cttacccctg cagttttcca gagcagctaa aaaacatcca agctggcaaa ccattcttcc    240

tactccaaac attaggagct tttaccagta agcaaggggt gggaagcttt tcctttcttg    300

aagatgctgc cagcgtagtt tcccttgtag ctgccatcct gggtgcatga cttgcaaaac    360

tgatatgtga gtgacaataa gccagatggc ctttgcaaaa gctctgctta ttttgatttt    420

tgtggttcct tacaaaaggc gaagtgagca ttgatctttg ttggtgctgt tgtagctcaa    480

cggcaacatc actgtgttgt ttcctcattt tatttttcct aaaaccttta cccattatct    540

gcagattttc acatctaagc aaaataggtt catatgagtc cagttaccta gacaattaat    600

aaaaaagagc aaaatgttga gtgactatgt cataggttac ttattgttaa gttacagctt    660

tgtaagcagc ttgctttgta aatttttcat cccctgatgg atgctgattt tagaaggtga    720

gagacgtgtt agaaggatgt gaatatcgtt ttatttattg gccataatta agtgcctttg    780

ggctttttgg gtacagggtt aaactacagc tcaacattta aatcaaatcc aaccataaaa    840

ttctcttaag tacaaaaaaa ccagatgacc aacctcaggg agaacccaag aaaaggtggg    900

ctttcccagc attgctgtgc agcattctga gaatacagct tgatttttct acatctttgc    960

atgggcaaca gtggtactgg gtcctgtctc ttgggacaag tttcactgtg attttaaatt   1020

tttgtttcaa cttggattct tcacgattga ccgtcaagtt gaaatcctgg ttttgacttt   1080

cactactgtg ggatgtgcac aggaagtttt ccaccaaatt ttccacgtcg ttcccctggc   1140

ttgtttaatg agagcttgga tttcagtttt actccaacac ctaaatagcc tgggtctcta   1200

ccagcatgcc actagggttt tacttcattt cagcctcctg tgggcattgg acacccggca   1260

ctctgtgagg gtaacatgaa agataggccc ttttcttacc caagctgatg tctgaagtac   1320

ccgttttcac atgactcgga attaggaatt gccgtcagat aacactgggc tcttctcact   1380

caccctttgc acttggagtt tttgttttac tgtttcctta acctgtcaca gtcccttaat   1440

tagaatgtat tgctagagga cagggtgcgt tgtccaactt tgtgcgcatt ttatagaaac   1500

acacaaaatc accagacaaa gcagctgtag tgtgaactca tccagatgcg atactgaaat   1560

tccccagagg ggcatcttca ttgttttctt tctttgttcc agaagcaaag gccgataatg   1620

aaccgagctg ttcgccggca gctcaagaac tgttgacaag gctgggattt ttactgggag   1680

aagggatccc aagtgccaca cacataacca ttgaagacaa aaatgaaacc atgtgcacag   1740

ctctgagtca aggcatcagt ccttgctcca cactaacaag cagcaccgca tctcctagca   1800

ccgatagccc ctgctcaacc ttgaatagct gtgtcagcaa gacggcagcc aacaaaagtc   1860

cctgtgagac cattagcagc cctagttcca ccctggaaag caaggacagt ggaattatag   1920

gtaagaagca cactgctcgg taacataatg gctcgaatct catcaaccag agcattcacc   1980

aggcacttcc tcagagggtt ttagcatggt ctgtgaaggt cagtctgcca gcgcctgctc   2040

tgttctttgc aggcagcact gactccatgt gtagctgaga gagtggagca ttggctttta   2100

cattccttga tgtttacttt ataacagtca gctcatttgt t                       2141


<210>  8544
<211>  70
<212>  PRT
<213>  Homosapiens

<400>  8544

Met Cys Thr Ala Leu Ser Gln Gly Ile Ser Pro Cys Ser Thr Leu Thr 
1               5                   10                  15      


Ser Ser Thr Ala Ser Pro Ser Thr Asp Ser Pro Cys Ser Thr Leu Asn 
            20                  25                  30          


Ser Cys Val Ser Lys Thr Ala Ala Asn Lys Ser Pro Cys Glu Thr Ile 
        35                  40                  45              


Ser Ser Pro Ser Ser Thr Leu Glu Ser Lys Asp Ser Gly Ile Ile Gly 
    50                  55                  60                  


Lys Lys His Thr Ala Arg 
65                  70  


<210>  8545
<211>  411
<212>  DNA
<213>  Homosapiens

<400>  8545
tgtttggaat tcccaactta ttaattaaat gggcagattc tatgtgtaca attccacagc     60

accgagaaca ctaaaagttg gctcagtagt aatagtataa tcatattcct aagcttcaaa    120

tatatgtgta gacttatata cacattctat atcataccgc attttttggt gttttttatt    180

ataaaaataa gttatgttta cctctgacca agtcagtaag actcatatca cctaagtatt    240

tgttataaag cattaaagag cagggtgcag tggctcacgc ctgtaatcac aggactttgg    300

gaggctgggg cgggtggatc gcttgaggtc aggagttcaa gaccagccca ccttggcctc    360

ctaaagtgct aggatccaac tttacccctt gccttctgaa ggttctatgt t             411


<210>  8546
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  8546

Asp Ser Tyr His Leu Ser Ile Cys Tyr Lys Ala Leu Lys Ser Arg Val 
1               5                   10                  15      


Gln Trp Leu Thr Pro Val Ile Thr Gly Leu Trp Glu Ala Gly Ala Gly 
            20                  25                  30          


Gly Ser Leu Glu Val Arg Ser Ser Arg Pro Ala His Leu Gly Leu Leu 
        35                  40                  45              


Lys Cys 
    50  


<210>  8547
<211>  7584
<212>  DNA
<213>  Homosapiens

<400>  8547
gaggagcggt gagctcccga ttgtagaagc ctagacagca cagagagtga cctgctccca     60

ggttaggaag taagatgtca gatgtttgca gatctctgtc tcagtctcac ttaatcacca    120

ttatacacaa tgtgtaagta gctcacggtg tttctgcggg gagggtgtgg aaagcagagg    180

ctggtgttga aggacagtct ggagtggtat cagtggccag gaaccacgcc agagaggaac    240

cacagcctct tgctgtgggg tggggccggg tagtgctgct gaaagctccc ccaggtgact    300

ctgagcagca gcggaggctg agccactgtt ctagagccac cagtcagctg tgtggggaaa    360

tggccaccac agcaagtttc tgtgaagaag tagtagtatg atttcatgga gacaaactag    420

gacgatactt gaggattgtg tgggggaccc tgagtaggga aagccctttc cacgtggctg    480

gctttgacac aaacacacca ttccagatgt ggggagggtc actattttgg tttgatgtat    540

ggagcccttg gtcaggagca gctctgggta gggcactgtg atgaaaatgc tattcactaa    600

tactgtcaag cagtgaatag tgccaggaac tatccaagca gtttcgccct ctgccttaat    660

ccctaccaca gccctgaaag tctcagtgac aatcccatga ttttacagat gaggaaacca    720

aggcaccgag cagctaaatg gcttccccca ggactgcctt gtggtactcg ccgtggggac    780

ctagcagctg gctccagggc tgtgctcttc agcactcctc ccacagtgtc ccgagagctc    840

aggcaggggt tagagaggtt gtggccgagc tgtagggtag gagagagaag ccatgacatc    900

tcggagtaca gcagatgaca cagcacaggg actgcgtgct gagaacacat gcctgcacgg    960

tggccgctgc aggaactgag gaggttatgc taaggcctca tttaattaat tttccccaca   1020

tcccacccgg aagggaggaa tgagttttcg ctgctcggat gccttcgttt ctcattactt   1080

ttttcagtaa aataacaagg acagatttga gtgcccaggt cagtgggaaa ggattagcaa   1140

cagcctcgcc ggcgtcctgc tccctccctc atcgtgctgt ggtccttgca gctgggctcc   1200

tgctggtgct gacctccagc cgtggggcca cggaggaatt gggatccttt ccgcagggcc   1260

tctgaagtgc ctctgaatgc gtgtttgttt tgcaggaaat gctgcttggg cgatggccac   1320

ttccaaacct gatatcttga ttatactttt acagaaatta atggaggaag gaaatgtgat   1380

gtacaaagta agtggttccg cccttttctt tgccattgaa actgcctggg agcaccctct   1440

taattgggta cataatggct acagctgtgc tactgcacag tctccatgta atagaagtgc   1500

aaaaagtggc tgggtggggt ggctcacgcc tgtaactcca gcacttttgg aggccgaggt   1560

gggcagatca cttgaggcca ggaattccag accaacctgg ccaatatggc aaaaccccat   1620

ctttactaaa aatacaaaaa tcagccaggt gcctgtaatc ccagctactc gggaggctga   1680

ggcaggagaa ttgtttcaat ctgggaggca gaggttgcag tgagctgaga ttgcaccact   1740

gcactccagc ctcagcaaca gagtgagact cagtctcaga agaaaaaaaa aaaaagtgcc   1800

aagaggtgct gacctggcct catgcccgtt gttggcttaa tatctttccg gcagaatctt   1860

aaaggtagaa agcacctctc tttgtgtctg agagccatta tttctgagct aatccttgag   1920

gttgtagtgg tgacttcctg tctgaagcca tggcgtgaag ctgagtcacc tctaggtcaa   1980

ctgaacatca tagagaaggt tcctcagccc ttcacattct gagttcagaa caccatgctg   2040

aggcacagtc atgagacgtg ggagaggaac acccagcaga catttctaga agaaaagggt   2100

tattctgtct cctaagcctt tcctaatttt taatatctat taatttctag aatttgaaag   2160

tgttgttaga gatttttact taatacagtc aagtaatacc tcagttactc agaagactga   2220

attaattttt tccattttcc cttggaaatg gaaatatgat ttacagatca ataaacttca   2280

ctttaaattt ttccaaataa gacatcagtt taggtcagag gtcagcaaac tttttttgta   2340

aagggccaga cagtaaatgt tttaggcttt gcagactgtg tggcctctgt cacaactccc   2400

cagttctgat gtgggggcac agatagcaca gagtgaatga acacagctgt gtcccaataa   2460

aactttattt gtaaacacag gtggctggcc agacttagta tccaagctat agtttgccaa   2520

cccctggttt agatagatat gcaggccatt tgcataggtc actattcttt gcagctctgt   2580

gattagacag aattaaaaga ttatagggga aaaactagat tatgaccatg ttaatccttt   2640

ttactgttag gcagctgtat ttggtatgtt gtagattttt tccttctcat tttttaaaat   2700

agtaacaaat aaataggcaa tatagcatga cccagcaggg ttcctggctt ggaatcagct   2760

tgaaattgag ttgagtgtat tgttgtggct ttgaagtgct tttaatatgg attggtaggc   2820

aattatgtca gaaataggaa gccattttca acaggcttca tacctgctgt gcaatgggac   2880

tgactgagca aatggatttt tttagctttg aaaatgatgt gtggtgctgt tctgattttt   2940

aaagcccatg ttttaattcc tcttagaaga aaaattatta ttctgcagca agctctctag   3000

gtttatctac aagatgctac ttgtcctagg aataggatca gtttttcatc tgatttctat   3060

tacacttagc attcaaatag atttgagatc attcttgaaa taattttcaa aaatacatac   3120

cagaaggtaa tctgattcat taagtttggt aattatcaat ctagcagttt acagacacct   3180

tattgtaaaa ccagcttctt tctcactgtg taaccacagg atgcgggtgc atgtgaggac   3240

agtgaagccc tcatgtgcca gcccagttag tgaactagct cccaccttga cacttgtttg   3300

gatgctttca atgttctgtc gtgggtttgc aggggggagt aaactcccca cggtgttcca   3360

ggtgtgggag ttattcattt tagaacctct gaaaaaggac aaatgtttgt gatttttgaa   3420

tcctagaaag ggaaaatgaa agaggcagcc cagaggtacc agtatgcctt aagaaagttt   3480

cctcgagaag gattcggaga ggacatgaga cccttcaatg aattaagggt ttccctctat   3540

ctcaatttgt cgcgatgccg aagaaaaaca aatgtaagct gtgccccttt attccaaccc   3600

agtcttccag caacagagcc cttctccagc agtgaaggcc agcccttctc cagaccagat   3660

cctgggccct cctgtccaat ttgcttgcac atttacatga acctggcatg tgggaaacag   3720

ctcctatccg tgactatcgt ttggtcacgg ctgctacgct cctcgcatga tgttgaagga   3780

atgcacttgg gtttcgtttc cttggcctca gtaatgagaa gcaaatgcag tctgctcctc   3840

tgcagcttcc caacactgtt gctgctggca ctgccgtccc cggattcagg agagtccaac   3900

ccaagcctat tgtggtgggc ctgccttctg tgttaggttt gctcagaggg tctgccagta   3960

actaatttgt aaccggtcgt ggggaactca tagtcgattt gtaactagta gatctgtttc   4020

agtagtactt cctacctttt ttttaactgt gtcctcctgc cccagtctgt tgagctgctt   4080

gcttctgtgc cctgctgccg gaatagatgc agtgtctgcg ctcctctctg aggctgcccc   4140

tccaccgggc tgtgaggttc caccatctgg ccttcttggg gcactgttac taccactgtt   4200

ttcatagtgg attcttctcc taatgatatt aatcaaccat cattatctcc tcactttaaa   4260

acaagataga aaacggaact ttcccttcct ccctctctgg ctgtgcctca gagcgctgct   4320

accctttaga acaaaactag acgggcttcc cacaatcgtg tgtccaggct gcttctgact   4380

cctgtatttc ttgtcgacac caggactttg gcatggcaga ggaatttgct tccaaggctc   4440

tcgaattgaa gcccaagtcc tatgaagcct tttatgccag agcaagagcg aagagaaata   4500

gcaggcaatt cgtggcagct ctggctgacc tgcaagaggc tgtgaaactc tgtcccacca   4560

atcaggaagt caagaggctt ctggcccgcg tagaagagga gtgcaaacaa ctccagagga   4620

gtcaacagca aaaacagcag ggcccgctac cagctccact caacgactcc gagaacgaag   4680

aggacacccc aacccctggc ttaagtgacc actttcactc tgaggagact gaagaggaag   4740

aaacttctcc ccaggaagaa tctgtttccc caactcccag gtcccagcca tcctcatctg   4800

tcccttcctc atacatccga aaccttcaag aagggttaca gtccaaagga aggccggtat   4860

cgccacagag cagggcagga atcggcaagt ccctgagaga gcctgtggcc cagccagggc   4920

tgctcctgca gccctccaag caggcccaga tcgtgaaaac cagccagcac ctgggctctg   4980

gccagtcggc agtgagaaat ggcagtatga aagttcagat ctcttctcag aaccctcctc   5040

caagtcccat gccagggaga atcgctgcca ctcctgctgg gagcagaacc cagcatttag   5100

agggaacagg tactttcact acaagagctg gttgtggcca ctttggggat cggctgggcc   5160

ccagccagaa tgtccgcctg cagtgtggtg agaatggccc tgcacaccct ttaccaagta   5220

agacgaaaac cacagagagg cttctgtctc attcctccgt ggctgtggac gcagcccctc   5280

caaaccaagg tgggctggcg acctgcagcg acgtgcgaca cccagcttcc ctcaccagct   5340

caggctcttc tggttctcca tccagcagca taaagatgtc aagttcaacc agtagtttga   5400

cttcgagcag cagtttttca gatggcttca aggtccaagg accagatact agaattaaag   5460

acaaggttgt aacccacgtt cagagcggta cagctgagca cagaccccgc aacacgccgt   5520

tcatgggcat catggataag actgcgaggt tccaacagca gagcaatcct ccaagccgca   5580

gctggcactg tccggcacca gaggggctgc tgacaaacac gtcttctgca gctggcctgc   5640

agtctgctaa cactgagaag ccctctctca tgcaagtggg aggatataat aaccaagcca   5700

aaacctgttc tgtttctacc ctgagtgcaa gtgtccacaa tggggcacaa gtgaaggagc   5760

tagaagaaag caagtgccaa attccagtcc actctcaaga gaacaggata actaagactg   5820

tttctcatct gtaccaggaa agtatctcca aacagcagcc tcatattagt aatgaagccc   5880

acaggagcca cctcactgca gccaaaccaa agcgatcatt tatagagtca aatgtgtgaa   5940

ccttaagaaa tccccatttg tggaatttgg aaacgtgtgt tgactcctgg tggtaaatta   6000

aatagttttt ttcatcagaa aaattatttt ttagccattt tttttctttg gggtggatct   6060

gatgccattg atatatctaa aatgtgggat aaaacttctt taatagctag aaatcaccat   6120

aaataagaat gctaaacaga attgaaaatt atatcaactt aaaattttaa gacagcccag   6180

aagacattaa tgactctcac ttatgaaatt gtttggcttt tgccactttc ttccttgcct   6240

ttgctatatg gtagaatcac agaacttact tagagaataa atatgtctat tgttcaagag   6300

taacaggttt aactcatgac caagtgatgt acatccaagt gatgtattct ggaaacgatg   6360

gaattttaca gttacagttc cattgagtca aatcccattt tatatataca taaaaattaa   6420

gttctgagtg agttctagct aaatataagt gcgactgtaa acgcagccaa tttttttaag   6480

cagaatatga gaacacctaa gtattctctt catagcagtt cctataaagg gattaaacac   6540

ttatttctgt gttatggttc ttattcatat atttttatag cacttttgga acctatattt   6600

gtgcttgaag gtgtttttga tatttggaaa cagtataagc catttggagt catgattggt   6660

ggtcaagtgg attcaagcta aaatactaag accagcattc ttagtggcgc ttataaatta   6720

gctctcacct ggtttccaaa ctgcttttaa caatggtagt gctcctggaa caatccttcc   6780

aagctcctct aaggacaata tttaattcag atactaaagg taagactggt tgttactttt   6840

gttttgttgt acaattagta ctttatagtc acatgttgta tatattaaat agcccagttt   6900

tattcagact tgtaaataga actatttcaa tgtagttaat ctaaaaacaa aaaagaaaac   6960

cccagtcacg atttgcatgt tctctgtaag cttcatccat gctggttatt gcactgaatg   7020

atatattatt agggcatgtt aacagtatac cagtaacagc actttatctc atttatatga   7080

acacctttga ggtgctactt aagtccaagc tctgatgtat tattcatttg taaagataag   7140

gtacaggaat gaaccttggt ttaaaggtat ttttatatga aaatggtgtg ttattggaag   7200

atgttaaaat gctaatttga gagaagtagg agtgtatctg ttttatatgt tgggatgtga   7260

aatttatttt ctaaaattga ggagaaggaa gttatatatt tgcagaatgt tttaaagtga   7320

attgttgtaa tgaagttcct gtgaacatca ttatggtttt gtacaaatag gaacctctga   7380

tgtcattctt caacgtttgt tcctgtgtgt acaattgtac tttgtatgaa cagctttatc   7440

atttttatag gctttccatg agttttgctg taactactat ggcttattta ttttctttaa   7500

tatttgtgaa agtcttactc ctttgttagt tttgtttctg cacaactact gtacttttcc   7560

atatggaata aagactatta atag                                          7584


<210>  8548
<211>  508
<212>  PRT
<213>  Homosapiens

<400>  8548

Met Ala Glu Glu Phe Ala Ser Lys Ala Leu Glu Leu Lys Pro Lys Ser 
1               5                   10                  15      


Tyr Glu Ala Phe Tyr Ala Arg Ala Arg Ala Lys Arg Asn Ser Arg Gln 
            20                  25                  30          


Phe Val Ala Ala Leu Ala Asp Leu Gln Glu Ala Val Lys Leu Cys Pro 
        35                  40                  45              


Thr Asn Gln Glu Val Lys Arg Leu Leu Ala Arg Val Glu Glu Glu Cys 
    50                  55                  60                  


Lys Gln Leu Gln Arg Ser Gln Gln Gln Lys Gln Gln Gly Pro Leu Pro 
65                  70                  75                  80  


Ala Pro Leu Asn Asp Ser Glu Asn Glu Glu Asp Thr Pro Thr Pro Gly 
                85                  90                  95      


Leu Ser Asp His Phe His Ser Glu Glu Thr Glu Glu Glu Glu Thr Ser 
            100                 105                 110         


Pro Gln Glu Glu Ser Val Ser Pro Thr Pro Arg Ser Gln Pro Ser Ser 
        115                 120                 125             


Ser Val Pro Ser Ser Tyr Ile Arg Asn Leu Gln Glu Gly Leu Gln Ser 
    130                 135                 140                 


Lys Gly Arg Pro Val Ser Pro Gln Ser Arg Ala Gly Ile Gly Lys Ser 
145                 150                 155                 160 


Leu Arg Glu Pro Val Ala Gln Pro Gly Leu Leu Leu Gln Pro Ser Lys 
                165                 170                 175     


Gln Ala Gln Ile Val Lys Thr Ser Gln His Leu Gly Ser Gly Gln Ser 
            180                 185                 190         


Ala Val Arg Asn Gly Ser Met Lys Val Gln Ile Ser Ser Gln Asn Pro 
        195                 200                 205             


Pro Pro Ser Pro Met Pro Gly Arg Ile Ala Ala Thr Pro Ala Gly Ser 
    210                 215                 220                 


Arg Thr Gln His Leu Glu Gly Thr Gly Thr Phe Thr Thr Arg Ala Gly 
225                 230                 235                 240 


Cys Gly His Phe Gly Asp Arg Leu Gly Pro Ser Gln Asn Val Arg Leu 
                245                 250                 255     


Gln Cys Gly Glu Asn Gly Pro Ala His Pro Leu Pro Ser Lys Thr Lys 
            260                 265                 270         


Thr Thr Glu Arg Leu Leu Ser His Ser Ser Val Ala Val Asp Ala Ala 
        275                 280                 285             


Pro Pro Asn Gln Gly Gly Leu Ala Thr Cys Ser Asp Val Arg His Pro 
    290                 295                 300                 


Ala Ser Leu Thr Ser Ser Gly Ser Ser Gly Ser Pro Ser Ser Ser Ile 
305                 310                 315                 320 


Lys Met Ser Ser Ser Thr Ser Ser Leu Thr Ser Ser Ser Ser Phe Ser 
                325                 330                 335     


Asp Gly Phe Lys Val Gln Gly Pro Asp Thr Arg Ile Lys Asp Lys Val 
            340                 345                 350         


Val Thr His Val Gln Ser Gly Thr Ala Glu His Arg Pro Arg Asn Thr 
        355                 360                 365             


Pro Phe Met Gly Ile Met Asp Lys Thr Ala Arg Phe Gln Gln Gln Ser 
    370                 375                 380                 


Asn Pro Pro Ser Arg Ser Trp His Cys Pro Ala Pro Glu Gly Leu Leu 
385                 390                 395                 400 


Thr Asn Thr Ser Ser Ala Ala Gly Leu Gln Ser Ala Asn Thr Glu Lys 
                405                 410                 415     


Pro Ser Leu Met Gln Val Gly Gly Tyr Asn Asn Gln Ala Lys Thr Cys 
            420                 425                 430         


Ser Val Ser Thr Leu Ser Ala Ser Val His Asn Gly Ala Gln Val Lys 
        435                 440                 445             


Glu Leu Glu Glu Ser Lys Cys Gln Ile Pro Val His Ser Gln Glu Asn 
    450                 455                 460                 


Arg Ile Thr Lys Thr Val Ser His Leu Tyr Gln Glu Ser Ile Ser Lys 
465                 470                 475                 480 


Gln Gln Pro His Ile Ser Asn Glu Ala His Arg Ser His Leu Thr Ala 
                485                 490                 495     


Ala Lys Pro Lys Arg Ser Phe Ile Glu Ser Asn Val 
            500                 505             


<210>  8549
<211>  3525
<212>  DNA
<213>  Homosapiens

<400>  8549
actttaaaac aagatagaaa acggaacttt cccttcctcc ctctctggct gtgcctcaga     60

gcgctgctac cctttagaac aaaactagac gggcttccca caatcgtgtg tccaggctgc    120

ttctgactcc tgtatttctt gtcgacacca ggactttggc atggcagagg aatttgcttc    180

caaggctctc gaattgaagc ccaagtccta tgaagccttt tatgccagag caagagcgaa    240

gagaaatagc aggcaattcg tggcagctct ggctgacctg caagaggctg tgaaactctg    300

tcccaccaat caggaagtca agaggcttct ggcccgcgta gaagaggagt gcaaacaact    360

ccagaggagt caacagcaaa aacagcaggg cccgctacca gctccactca acgactccga    420

gaacgaagag gacaccccaa cccctggctt aagtgaccac tttcactctg aggagactga    480

agaggaagaa acttctcccc aggaagaatc tgtttcccca actcccaggt cccagccatc    540

ctcatctgtc ccttcctcat acatccgaaa ccttcaagaa gggttacagt ccaaaggaag    600

gccggtatcg ccacagagca gggcaggaat cggcaagtcc ctgagagagc ctgtggccca    660

gccagggctg ctcctgcagc cctccaagca ggcccagatc gtgaaaacca gccagcacct    720

gggctctggc cagtcggcag tgagaaatgg cagtatgaaa gttcagatct cttctcagaa    780

ccctcctcca agtcccatgc cagggagaat cgctgccact cctgctggga gcagaaccca    840

gcatttagag ggaacaggta ctttcactac aagagctggt tgtggccact ttggggatcg    900

gctgggcccc agccagaatg tccgcctgca gtgtggtgag aatggccctg cacacccttt    960

accaagtaag acgaaaacca cagagaggct tctgtctcat tcctccgtgg ctgtggacgc   1020

agcccctcca aaccaaggtg ggctggcgac ctgcagcgac gtgcgacacc cagcttccct   1080

caccagctca ggctcttctg gttctccatc cagcagcata aagatgtcaa gttcaaccag   1140

tagtttgact tcgagcagca gtttttcaga tggcttcaag gtccaaggac cagatactag   1200

aattaaagac aaggttgtaa cccacgttca gagcggtaca gctgagcaca gaccccgcaa   1260

cacgccgttc atgggcatca tggataagac tgcgaggttc caacagcaga gcaatcctcc   1320

aagccgcagc tggcactgtc cggcaccaga ggggctgctg acaaacacgt cttctgcagc   1380

tggcctgcag tctgctaaca ctgagaagcc ctctctcatg caagtgggag gatataataa   1440

ccaagccaaa acctgttctg tttctaccct gagtgcaagt gtccacaatg gggcacaagt   1500

gaaggagcta gaagaaagca agtgccaaat tccagtccac tctcaagaga acaggataac   1560

taagactgtt tctcatctgt accaggaaag tatctccaaa cagcagcctc atattagtaa   1620

tgaagcccac aggagccacc tcactgcagc caaaccaaag cgatcattta tagagtcaaa   1680

tgtgtgaacc ttaagaaatc cccatttgtg gaatttggaa acgtgtgttg actcctggtg   1740

gtaaattaaa tagttttttt catcagaaaa attatttttt agccattttt tttctttggg   1800

gtggatctga tgccattgat atatctaaaa tgtgggataa aacttcttta atagctagaa   1860

atcaccataa ataagaatgc taaacagaat tgaaaattat atcaacttaa aattttaaga   1920

cagcccagaa gacattaatg actctcactt atgaaattgt ttggcttttg ccactttctt   1980

ccttgccttt gctatatggt agaatcacag aacttactta gagaataaat atgtctattg   2040

ttcaagagta acaggtttaa ctcatgacca agtgatgtac atccaagtga tgtattctgg   2100

aaacgatgga attttacagt tacagttcca ttgagtcaaa tcccatttta tatatacata   2160

aaaattaagt tctgagtgag ttctagctaa atataagtgc gactgtaaac gcagccaatt   2220

tttttaagca gaatatgaga acacctaagt attctcttca tagcagttcc tataaaggga   2280

ttaaacactt atttctgtgt tatggttctt attcatatat ttttatagca cttttggaac   2340

ctatatttgt gcttgaaggt gtttttgata tttggaaaca gtataagcca tttggagtca   2400

tgattggtgg tcaagtggat tcaagctaaa atactaagac cagcattctt agtggcgctt   2460

ataaattagc tctcacctgg tttccaaact gcttttaaca atggtagtgc tcctggaaca   2520

atccttccaa gctcctctaa ggacaatatt taattcagat actaaaggta agactggttg   2580

ttacttttgt tttgttgtac aattagtact ttatagtcac atgttgtata tattaaatag   2640

cccagtttta ttcagacttg taaatagaac tatttcaatg tagttaatct aaaaacaaaa   2700

aagaaaaccc cagtcacgat ttgcatgttc tctgtaagct tcatccatgc tggttattgc   2760

actgaatgat atattattag ggcatgttaa cagtatacca gtaacagcac tttatctcat   2820

ttatatgaac acctttgagg tgctacttaa gtccaagctc tgatgtatta ttcatttgta   2880

aagataaggt acaggaatga accttggttt aaaggtattt ttatatgaaa atggtgtgtt   2940

attggaagat gttaaaatgc taatttgaga gaagtaggag tgtatctgtt ttatatgttg   3000

ggatgtgaaa tttattttct aaaattgagg agaaggaagt tatatatttg cagaatgttt   3060

taaagtgaat tgttgtaatg aagttcctgt gaacatcatt atggttttgt acaaatagga   3120

acctctgatg tcattcttca acgtttgttc ctgtgtgtac aattgtactt tgtatgaaca   3180

gctttatcat ttttataggc tttccatgag ttttgctgta actactatgg cttatttatt   3240

ttctttaata tttgtgaaag tcttactcct ttgttagttt tgtttctgca caactactgt   3300

acttttccat atggaataaa gactattaat agaatgtgtt ttgcactaaa tgagtcaatg   3360

gataagtaga gaacagcctg atgacagcta tctctgttgc ttttaatctt tgttacccta   3420

gagggaatag tgaaaagcat attttatatt aacactacaa aatgcttatt taatttcgtt   3480

ttataatttc agaataaggg tgacagctgc tagaaattcc acaat                   3525


<210>  8550
<211>  508
<212>  PRT
<213>  Homosapiens

<400>  8550

Met Ala Glu Glu Phe Ala Ser Lys Ala Leu Glu Leu Lys Pro Lys Ser 
1               5                   10                  15      


Tyr Glu Ala Phe Tyr Ala Arg Ala Arg Ala Lys Arg Asn Ser Arg Gln 
            20                  25                  30          


Phe Val Ala Ala Leu Ala Asp Leu Gln Glu Ala Val Lys Leu Cys Pro 
        35                  40                  45              


Thr Asn Gln Glu Val Lys Arg Leu Leu Ala Arg Val Glu Glu Glu Cys 
    50                  55                  60                  


Lys Gln Leu Gln Arg Ser Gln Gln Gln Lys Gln Gln Gly Pro Leu Pro 
65                  70                  75                  80  


Ala Pro Leu Asn Asp Ser Glu Asn Glu Glu Asp Thr Pro Thr Pro Gly 
                85                  90                  95      


Leu Ser Asp His Phe His Ser Glu Glu Thr Glu Glu Glu Glu Thr Ser 
            100                 105                 110         


Pro Gln Glu Glu Ser Val Ser Pro Thr Pro Arg Ser Gln Pro Ser Ser 
        115                 120                 125             


Ser Val Pro Ser Ser Tyr Ile Arg Asn Leu Gln Glu Gly Leu Gln Ser 
    130                 135                 140                 


Lys Gly Arg Pro Val Ser Pro Gln Ser Arg Ala Gly Ile Gly Lys Ser 
145                 150                 155                 160 


Leu Arg Glu Pro Val Ala Gln Pro Gly Leu Leu Leu Gln Pro Ser Lys 
                165                 170                 175     


Gln Ala Gln Ile Val Lys Thr Ser Gln His Leu Gly Ser Gly Gln Ser 
            180                 185                 190         


Ala Val Arg Asn Gly Ser Met Lys Val Gln Ile Ser Ser Gln Asn Pro 
        195                 200                 205             


Pro Pro Ser Pro Met Pro Gly Arg Ile Ala Ala Thr Pro Ala Gly Ser 
    210                 215                 220                 


Arg Thr Gln His Leu Glu Gly Thr Gly Thr Phe Thr Thr Arg Ala Gly 
225                 230                 235                 240 


Cys Gly His Phe Gly Asp Arg Leu Gly Pro Ser Gln Asn Val Arg Leu 
                245                 250                 255     


Gln Cys Gly Glu Asn Gly Pro Ala His Pro Leu Pro Ser Lys Thr Lys 
            260                 265                 270         


Thr Thr Glu Arg Leu Leu Ser His Ser Ser Val Ala Val Asp Ala Ala 
        275                 280                 285             


Pro Pro Asn Gln Gly Gly Leu Ala Thr Cys Ser Asp Val Arg His Pro 
    290                 295                 300                 


Ala Ser Leu Thr Ser Ser Gly Ser Ser Gly Ser Pro Ser Ser Ser Ile 
305                 310                 315                 320 


Lys Met Ser Ser Ser Thr Ser Ser Leu Thr Ser Ser Ser Ser Phe Ser 
                325                 330                 335     


Asp Gly Phe Lys Val Gln Gly Pro Asp Thr Arg Ile Lys Asp Lys Val 
            340                 345                 350         


Val Thr His Val Gln Ser Gly Thr Ala Glu His Arg Pro Arg Asn Thr 
        355                 360                 365             


Pro Phe Met Gly Ile Met Asp Lys Thr Ala Arg Phe Gln Gln Gln Ser 
    370                 375                 380                 


Asn Pro Pro Ser Arg Ser Trp His Cys Pro Ala Pro Glu Gly Leu Leu 
385                 390                 395                 400 


Thr Asn Thr Ser Ser Ala Ala Gly Leu Gln Ser Ala Asn Thr Glu Lys 
                405                 410                 415     


Pro Ser Leu Met Gln Val Gly Gly Tyr Asn Asn Gln Ala Lys Thr Cys 
            420                 425                 430         


Ser Val Ser Thr Leu Ser Ala Ser Val His Asn Gly Ala Gln Val Lys 
        435                 440                 445             


Glu Leu Glu Glu Ser Lys Cys Gln Ile Pro Val His Ser Gln Glu Asn 
    450                 455                 460                 


Arg Ile Thr Lys Thr Val Ser His Leu Tyr Gln Glu Ser Ile Ser Lys 
465                 470                 475                 480 


Gln Gln Pro His Ile Ser Asn Glu Ala His Arg Ser His Leu Thr Ala 
                485                 490                 495     


Ala Lys Pro Lys Arg Ser Phe Ile Glu Ser Asn Val 
            500                 505             


<210>  8551
<211>  1819
<212>  DNA
<213>  Homosapiens

<400>  8551
agcggcggtg gcggcaggtg gggaagcgcg gctgggcctg ctcgcgcggg gcgtctgagc     60

cctccatttc ccggttctaa ccgcgcagca gggcccaacc gggaccttga gtgcggcgag    120

gcgtggctgt ttttcttcaa ataaagaaca tggtgaaact gattcacaca ttagctgatc    180

atggtgacga tgtcaactgc tgtgccttct ccttttccct cttggctact tgctccttgg    240

acaaaacaat tcgcctgtac tcgttacgtg actttactga actgccacat tctccattga    300

agtttcatac ctatgctgtc cactgctgct gtttctcccc ttcaggacat attttggcat    360

cgtgttcaac agatggtacc actgtcctat ggaatactga aaatggacag atgctggcag    420

tgatggaaca gcctagtggc agccctgtga gggtttgcca gttttcccca gactccacgt    480

gtttggcatc aggggcagct gatggaactg tggttttgtg gaatgcacag tcatacaaat    540

tatatagatg tggtagtgtt aaagatggct ccttggcggc atgtgcattt tctcctaatg    600

gaagcttctt tgtcactggc tcctcatgtg gtgatttaac agtgtgggat gataaaatga    660

ggtgtccgca tagtgaaaaa gcacatgatc ttggaattac ctgctgcgat ttttcttcac    720

agccagtttc tgatggagaa caaggtcttc agttttttcg actggcatca tgtggtcagg    780

attgccaagt caaaatttgg attgtttctt ttacccatat cttaggtttt gaattaaaat    840

ataaaagtac actgagtggg cactgtgctc ctgttctggc ttgtgctttt tcccatgatg    900

ggcagatgct agtctcaggg tcagtggata agtctgtcat agtatatgat actaatactg    960

agaatatact tcacacattg actcagcaca ccaggtatgt cacaacttgt gcttttgcac   1020

ctaataccct tttacttgct actggttcaa tggacaaaac agtgaacatc tggcaatttg   1080

acctggaaac actttgccaa gcaaggcgca cagaacatca gctgaagcaa tttaccgaag   1140

attggtcaga ggaggatgtc tcaacatggc tttgtgcaca agatttaaaa gatcttgttg   1200

gtattttcaa gatgaataac attgatggaa aagaactgtt gaatcttaca aaagaaagtc   1260

tggctgatga tttgaaaatt gaatctctag gactgcgtag taaagtgctg aggaaaattg   1320

aagagctcag gaccaaggtt aaatcccttt cttcaggaat tcctgatgaa tttatatgtc   1380

caataactag agaacttatg aaagatccgg tcatcgcatc agatggctat tcatatgaaa   1440

aggaagcaat ggaaaattgg atcagcaaaa agaaacgtac aagtcccatg acaaatcttg   1500

ttcttccttc agcggtactt acaccaaata ggactctgaa aatggccatc aatagatggc   1560

tggagacaca ccaaaagtaa aattgttgat attgtattat ttatattttc agtgatctca   1620

tttgaatgat ttataggtaa atactaatca gacattatta aaagcaaaac aggaaaaagg   1680

taaacttctt aaatttagtt acctataaaa attgtcaatt ttcattcttt aaaaaacaca   1740

tggacttact ataaaagcct ttttgtacta gtgaaaagaa tcttcagcta tatagaaata   1800

aagttatact ttaaattgc                                                1819


<210>  8552
<211>  476
<212>  PRT
<213>  Homosapiens

<400>  8552

Met Val Lys Leu Ile His Thr Leu Ala Asp His Gly Asp Asp Val Asn 
1               5                   10                  15      


Cys Cys Ala Phe Ser Phe Ser Leu Leu Ala Thr Cys Ser Leu Asp Lys 
            20                  25                  30          


Thr Ile Arg Leu Tyr Ser Leu Arg Asp Phe Thr Glu Leu Pro His Ser 
        35                  40                  45              


Pro Leu Lys Phe His Thr Tyr Ala Val His Cys Cys Cys Phe Ser Pro 
    50                  55                  60                  


Ser Gly His Ile Leu Ala Ser Cys Ser Thr Asp Gly Thr Thr Val Leu 
65                  70                  75                  80  


Trp Asn Thr Glu Asn Gly Gln Met Leu Ala Val Met Glu Gln Pro Ser 
                85                  90                  95      


Gly Ser Pro Val Arg Val Cys Gln Phe Ser Pro Asp Ser Thr Cys Leu 
            100                 105                 110         


Ala Ser Gly Ala Ala Asp Gly Thr Val Val Leu Trp Asn Ala Gln Ser 
        115                 120                 125             


Tyr Lys Leu Tyr Arg Cys Gly Ser Val Lys Asp Gly Ser Leu Ala Ala 
    130                 135                 140                 


Cys Ala Phe Ser Pro Asn Gly Ser Phe Phe Val Thr Gly Ser Ser Cys 
145                 150                 155                 160 


Gly Asp Leu Thr Val Trp Asp Asp Lys Met Arg Cys Pro His Ser Glu 
                165                 170                 175     


Lys Ala His Asp Leu Gly Ile Thr Cys Cys Asp Phe Ser Ser Gln Pro 
            180                 185                 190         


Val Ser Asp Gly Glu Gln Gly Leu Gln Phe Phe Arg Leu Ala Ser Cys 
        195                 200                 205             


Gly Gln Asp Cys Gln Val Lys Ile Trp Ile Val Ser Phe Thr His Ile 
    210                 215                 220                 


Leu Gly Phe Glu Leu Lys Tyr Lys Ser Thr Leu Ser Gly His Cys Ala 
225                 230                 235                 240 


Pro Val Leu Ala Cys Ala Phe Ser His Asp Gly Gln Met Leu Val Ser 
                245                 250                 255     


Gly Ser Val Asp Lys Ser Val Ile Val Tyr Asp Thr Asn Thr Glu Asn 
            260                 265                 270         


Ile Leu His Thr Leu Thr Gln His Thr Arg Tyr Val Thr Thr Cys Ala 
        275                 280                 285             


Phe Ala Pro Asn Thr Leu Leu Leu Ala Thr Gly Ser Met Asp Lys Thr 
    290                 295                 300                 


Val Asn Ile Trp Gln Phe Asp Leu Glu Thr Leu Cys Gln Ala Arg Arg 
305                 310                 315                 320 


Thr Glu His Gln Leu Lys Gln Phe Thr Glu Asp Trp Ser Glu Glu Asp 
                325                 330                 335     


Val Ser Thr Trp Leu Cys Ala Gln Asp Leu Lys Asp Leu Val Gly Ile 
            340                 345                 350         


Phe Lys Met Asn Asn Ile Asp Gly Lys Glu Leu Leu Asn Leu Thr Lys 
        355                 360                 365             


Glu Ser Leu Ala Asp Asp Leu Lys Ile Glu Ser Leu Gly Leu Arg Ser 
    370                 375                 380                 


Lys Val Leu Arg Lys Ile Glu Glu Leu Arg Thr Lys Val Lys Ser Leu 
385                 390                 395                 400 


Ser Ser Gly Ile Pro Asp Glu Phe Ile Cys Pro Ile Thr Arg Glu Leu 
                405                 410                 415     


Met Lys Asp Pro Val Ile Ala Ser Asp Gly Tyr Ser Tyr Glu Lys Glu 
            420                 425                 430         


Ala Met Glu Asn Trp Ile Ser Lys Lys Lys Arg Thr Ser Pro Met Thr 
        435                 440                 445             


Asn Leu Val Leu Pro Ser Ala Val Leu Thr Pro Asn Arg Thr Leu Lys 
    450                 455                 460                 


Met Ala Ile Asn Arg Trp Leu Glu Thr His Gln Lys 
465                 470                 475     


<210>  8553
<211>  1927
<212>  DNA
<213>  Homosapiens

<400>  8553
gctcctgcag gtgagagcgg ccgcgcccac gggccggctc agcggcggtg gcggcaggtg     60

gggaagcgcg gctgggcctg ctcgcgcggg gcgtctgagc cctccatttc ccggttctaa    120

ccgcgcagca gggcccaacc gggaccttga gtgcggcgag gcgtggttcg tgcacccttg    180

gcccggggct agggcgggcg tgtcggcgtc gggtggaagg aagccccttg cgggctgttt    240

ttcttcaaat aaagaacatg gtgaaactga ttcacacatt agctgatcat ggtgacgatg    300

tcaactgctg tgccttctcc ttttccctct tggctacttg ctccttggac aaaacaattc    360

gcctgtactc gttacgtgac tttactgaac tgccacattc tccattgaag tttcatacct    420

atgctgtcca ctgctgctgt ttctcccctt caggacatat tttggcatcg tgttcaacag    480

atggtaccac tgtcctatgg aatactgaaa atggacagat gctggcagtg atggaacagc    540

ctagtggcag ccctgtgagg gtttgccagt tttccccaga ctccacgtgt ttggcatcag    600

gggcagctga tggaactgtg gttttgtgga atgcacagtc atacaaatta tatagatgtg    660

gtagtgttaa agatggctcc ttggcggcat gtgcattttc tcctaatgga agcttctttg    720

tcactggctc ctcatgtggt gatttaacag tgtgggatga taaaatgagg tgtccgcata    780

gtgaaaaagc acatgatctt ggaattacct gctgcgattt ttcttcacag ccagtttctg    840

atggagaaca aggtcttcag ttttttcgac tggcatcatg tggtcaggat tgccaagtca    900

aaatttggat tgtttctttt acccatatct taggttttga attaaaatat aaaagtacac    960

tgagtgggca ctgtgctcct gttctggctt gtgctttttc ccatgatggg cagatgctag   1020

tctcagggtc agtggataag tctgtcatag tatatgatac taatactgag aatatacttc   1080

acacattgac tcagcacacc aggtatgtca caacttgtgc ttttgcacct aatacccttt   1140

tacttgctac tggttcaatg gacaaaacag tgaacatctg gcaatttgac ctggaaacac   1200

tttgccaagc aaggcgcaca gaacatcagc tgaagcaatt taccgaagat tggtcagagg   1260

aggatgtctc aacatggctt tgtgcacaag atttaaaaga tcttgttggt attttcaaga   1320

tgaataacat tgatggaaaa gaactgttga atcttacaaa agaaagtctg gctgatgatt   1380

tgaaaattga atctctagga ctgcgtagta aagtgctgag gaaaattgaa gagctcagga   1440

ccaaggttaa atccctttct tcaggaattc ctgatgaatt tatatgtcca ataactagag   1500

aacttatgaa agatccggtc atcgcatcag atggctattc atatgaaaag gaagcaatgg   1560

aaaattggat cagcaaaaag aaacgtacaa gtcccatgac aaatcttgtt cttccttcag   1620

cggtacttac accaaatagg actctgaaaa tggccatcaa tagatggctg gagacacacc   1680

aaaagtaaaa ttgttgatat tgtattattt atattttcag tgatctcatt tgaatgattt   1740

ataggtaaat actaatcaga cattattaaa agcaaaacag gaaaaaggta aacttcttaa   1800

atttagttac ctataaaaat tgtcaatttt cattctttaa aaaacacatg gacttactat   1860

aaaagccttt ttgtactagt gaaaagaatc ttcagctata tagaaataaa gttatacttt   1920

aaattgc                                                             1927


<210>  8554
<211>  476
<212>  PRT
<213>  Homosapiens

<400>  8554

Met Val Lys Leu Ile His Thr Leu Ala Asp His Gly Asp Asp Val Asn 
1               5                   10                  15      


Cys Cys Ala Phe Ser Phe Ser Leu Leu Ala Thr Cys Ser Leu Asp Lys 
            20                  25                  30          


Thr Ile Arg Leu Tyr Ser Leu Arg Asp Phe Thr Glu Leu Pro His Ser 
        35                  40                  45              


Pro Leu Lys Phe His Thr Tyr Ala Val His Cys Cys Cys Phe Ser Pro 
    50                  55                  60                  


Ser Gly His Ile Leu Ala Ser Cys Ser Thr Asp Gly Thr Thr Val Leu 
65                  70                  75                  80  


Trp Asn Thr Glu Asn Gly Gln Met Leu Ala Val Met Glu Gln Pro Ser 
                85                  90                  95      


Gly Ser Pro Val Arg Val Cys Gln Phe Ser Pro Asp Ser Thr Cys Leu 
            100                 105                 110         


Ala Ser Gly Ala Ala Asp Gly Thr Val Val Leu Trp Asn Ala Gln Ser 
        115                 120                 125             


Tyr Lys Leu Tyr Arg Cys Gly Ser Val Lys Asp Gly Ser Leu Ala Ala 
    130                 135                 140                 


Cys Ala Phe Ser Pro Asn Gly Ser Phe Phe Val Thr Gly Ser Ser Cys 
145                 150                 155                 160 


Gly Asp Leu Thr Val Trp Asp Asp Lys Met Arg Cys Pro His Ser Glu 
                165                 170                 175     


Lys Ala His Asp Leu Gly Ile Thr Cys Cys Asp Phe Ser Ser Gln Pro 
            180                 185                 190         


Val Ser Asp Gly Glu Gln Gly Leu Gln Phe Phe Arg Leu Ala Ser Cys 
        195                 200                 205             


Gly Gln Asp Cys Gln Val Lys Ile Trp Ile Val Ser Phe Thr His Ile 
    210                 215                 220                 


Leu Gly Phe Glu Leu Lys Tyr Lys Ser Thr Leu Ser Gly His Cys Ala 
225                 230                 235                 240 


Pro Val Leu Ala Cys Ala Phe Ser His Asp Gly Gln Met Leu Val Ser 
                245                 250                 255     


Gly Ser Val Asp Lys Ser Val Ile Val Tyr Asp Thr Asn Thr Glu Asn 
            260                 265                 270         


Ile Leu His Thr Leu Thr Gln His Thr Arg Tyr Val Thr Thr Cys Ala 
        275                 280                 285             


Phe Ala Pro Asn Thr Leu Leu Leu Ala Thr Gly Ser Met Asp Lys Thr 
    290                 295                 300                 


Val Asn Ile Trp Gln Phe Asp Leu Glu Thr Leu Cys Gln Ala Arg Arg 
305                 310                 315                 320 


Thr Glu His Gln Leu Lys Gln Phe Thr Glu Asp Trp Ser Glu Glu Asp 
                325                 330                 335     


Val Ser Thr Trp Leu Cys Ala Gln Asp Leu Lys Asp Leu Val Gly Ile 
            340                 345                 350         


Phe Lys Met Asn Asn Ile Asp Gly Lys Glu Leu Leu Asn Leu Thr Lys 
        355                 360                 365             


Glu Ser Leu Ala Asp Asp Leu Lys Ile Glu Ser Leu Gly Leu Arg Ser 
    370                 375                 380                 


Lys Val Leu Arg Lys Ile Glu Glu Leu Arg Thr Lys Val Lys Ser Leu 
385                 390                 395                 400 


Ser Ser Gly Ile Pro Asp Glu Phe Ile Cys Pro Ile Thr Arg Glu Leu 
                405                 410                 415     


Met Lys Asp Pro Val Ile Ala Ser Asp Gly Tyr Ser Tyr Glu Lys Glu 
            420                 425                 430         


Ala Met Glu Asn Trp Ile Ser Lys Lys Lys Arg Thr Ser Pro Met Thr 
        435                 440                 445             


Asn Leu Val Leu Pro Ser Ala Val Leu Thr Pro Asn Arg Thr Leu Lys 
    450                 455                 460                 


Met Ala Ile Asn Arg Trp Leu Glu Thr His Gln Lys 
465                 470                 475     


<210>  8555
<211>  1560
<212>  DNA
<213>  Homosapiens

<400>  8555
gcgggcgttc gggggcgggg cctgttccct ctgctctggg tctccgccgg cgcccgcccc     60

gccagcctca cctgcgcggc acgtgacccg caccgcccgt gggcaccttg aaggcggatc    120

ccgcgcgccc ccgctcctgc aggctgtttt tcttcaaata aagaacatgg tgaaactgat    180

tcacacatta gctgatcatg gtgacgatgt caactgctgt gccttctcct tttccctctt    240

ggctacttgc tccttggaca aaacaattcg cctgtactcg ttacgtgact ttactgaact    300

gccacattct ccattgaagt ttcataccta tgctgtccac tgctgctgtt tctccccttc    360

aggacatatt ttggcatcgt gttcaacaga tggtaccact gtcctatgga atactgaaaa    420

tggacagatg ctggcagtga tggaacagcc tagtggcagc cctgtgaggg tttgccagtt    480

ttccccagac tccacgtgtt tggcatcagg ggcagctgat ggaactgtgg ttttgtggaa    540

tgcacagtca tacaaattat atagatgtgg tagtgttaaa gatggctcct tggcggcatg    600

tgcattttct cctaatggaa gcttctttgt cactggctcc tcatgtggtg atttaacagt    660

gtgggatgat aaaatgaggt gtccgcatag tgaaaaagca catgatcttg gaattacctg    720

ctgcgatttt tcttcacagc cagtttctga tggagaacaa ggtcttcagt tttttcgact    780

ggcatcatgt ggtcaggatt gccaagtcaa aatttggatt gtttctttta cccatatctt    840

agcaaggcgc acagaacatc agctgaagca atttaccgaa gattggtcag aggaggatgt    900

ctcaacatgg ctttgtgcac aagatttaaa agatcttgtt ggtattttca agatgaataa    960

cattgatgga aaagaactgt tgaatcttac aaaagaaagt ctggctgatg atttgaaaat   1020

tgaatctcta ggactgcgta gtaaagtgct gaggaaaatt gaagagctca ggaccaaggt   1080

taaatccctt tcttcaggaa ttcctgatga atttatatgt ccaataacta gagaacttat   1140

gaaagatccg gtcatcgcat cagatggcta ttcatatgaa aaggaagcaa tggaaaattg   1200

gatcagcaaa aagaaacgta caagtcccat gacaaatctt gttcttcctt cagcggtact   1260

tacaccaaat aggactctga aaatggccat caatagatgg ctggagacac accaaaagta   1320

aaattgttga tattgtatta tttatatttt cagtgatctc atttgaatga tttataggta   1380

aatactaatc agacattatt aaaagcaaaa caggaaaaag gtaaacttct taaatttagt   1440

tacctataaa aattgtcaat tttcattctt taaaaaacac atggacttac tataaaagcc   1500

tttttgtact agtgaaaaga atcttcagct atatagaaat aaagttatac tttaaattgc   1560


<210>  8556
<211>  384
<212>  PRT
<213>  Homosapiens

<400>  8556

Met Val Lys Leu Ile His Thr Leu Ala Asp His Gly Asp Asp Val Asn 
1               5                   10                  15      


Cys Cys Ala Phe Ser Phe Ser Leu Leu Ala Thr Cys Ser Leu Asp Lys 
            20                  25                  30          


Thr Ile Arg Leu Tyr Ser Leu Arg Asp Phe Thr Glu Leu Pro His Ser 
        35                  40                  45              


Pro Leu Lys Phe His Thr Tyr Ala Val His Cys Cys Cys Phe Ser Pro 
    50                  55                  60                  


Ser Gly His Ile Leu Ala Ser Cys Ser Thr Asp Gly Thr Thr Val Leu 
65                  70                  75                  80  


Trp Asn Thr Glu Asn Gly Gln Met Leu Ala Val Met Glu Gln Pro Ser 
                85                  90                  95      


Gly Ser Pro Val Arg Val Cys Gln Phe Ser Pro Asp Ser Thr Cys Leu 
            100                 105                 110         


Ala Ser Gly Ala Ala Asp Gly Thr Val Val Leu Trp Asn Ala Gln Ser 
        115                 120                 125             


Tyr Lys Leu Tyr Arg Cys Gly Ser Val Lys Asp Gly Ser Leu Ala Ala 
    130                 135                 140                 


Cys Ala Phe Ser Pro Asn Gly Ser Phe Phe Val Thr Gly Ser Ser Cys 
145                 150                 155                 160 


Gly Asp Leu Thr Val Trp Asp Asp Lys Met Arg Cys Pro His Ser Glu 
                165                 170                 175     


Lys Ala His Asp Leu Gly Ile Thr Cys Cys Asp Phe Ser Ser Gln Pro 
            180                 185                 190         


Val Ser Asp Gly Glu Gln Gly Leu Gln Phe Phe Arg Leu Ala Ser Cys 
        195                 200                 205             


Gly Gln Asp Cys Gln Val Lys Ile Trp Ile Val Ser Phe Thr His Ile 
    210                 215                 220                 


Leu Ala Arg Arg Thr Glu His Gln Leu Lys Gln Phe Thr Glu Asp Trp 
225                 230                 235                 240 


Ser Glu Glu Asp Val Ser Thr Trp Leu Cys Ala Gln Asp Leu Lys Asp 
                245                 250                 255     


Leu Val Gly Ile Phe Lys Met Asn Asn Ile Asp Gly Lys Glu Leu Leu 
            260                 265                 270         


Asn Leu Thr Lys Glu Ser Leu Ala Asp Asp Leu Lys Ile Glu Ser Leu 
        275                 280                 285             


Gly Leu Arg Ser Lys Val Leu Arg Lys Ile Glu Glu Leu Arg Thr Lys 
    290                 295                 300                 


Val Lys Ser Leu Ser Ser Gly Ile Pro Asp Glu Phe Ile Cys Pro Ile 
305                 310                 315                 320 


Thr Arg Glu Leu Met Lys Asp Pro Val Ile Ala Ser Asp Gly Tyr Ser 
                325                 330                 335     


Tyr Glu Lys Glu Ala Met Glu Asn Trp Ile Ser Lys Lys Lys Arg Thr 
            340                 345                 350         


Ser Pro Met Thr Asn Leu Val Leu Pro Ser Ala Val Leu Thr Pro Asn 
        355                 360                 365             


Arg Thr Leu Lys Met Ala Ile Asn Arg Trp Leu Glu Thr His Gln Lys 
    370                 375                 380                 


<210>  8557
<211>  682
<212>  DNA
<213>  Homosapiens

<400>  8557
tgaatgttta ccctagggtt tttggtgaat atggttgaaa gtgacctacc attcttagag     60

tcctggctgg atttagggag aggcataaga aaggataggt tatcatggac ttggaaaatg    120

ggagtttttt atgcacccgg ccaagggact aatttctact cactggtcct gcaatgtata    180

caagtcaaat gccatagtca aaaatatgaa ttatttcagg taatagatgt ttaggttact    240

attagtaggt tcaaacagat gagcaaatgc caagggtcta ctgtactaaa aatttctaag    300

gaggtggcta gcagacaata atgccgataa ttgacaaaaa gtgaagtaag tacctgagaa    360

tgctgttaca gatgctgttt ctgctattca ttgagtaaag tttcaactta tgttagttac    420

taataaatat taatatatcc acttagtata caacccattt atgtcaaatg agtcttcatc    480

agtaacttta ctcttacttg agtaaattta aagctgtttt tattgttttt cagaatactg    540

agaatatact tcacacattg actcagcaca ccaggtatgt cacaacttgt gcttttgcac    600

ctaataccct tttacttgct actggttcaa tggacaaaac agtgaacatc tggcaatttg    660

acctggaaac actttgccaa gg                                             682


<210>  8558
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  8558

Met Phe Thr Leu Gly Phe Leu Val Asn Met Val Glu Ser Asp Leu Pro 
1               5                   10                  15      


Phe Leu Glu Ser Trp Leu Asp Leu Gly Arg Gly Ile Arg Lys Asp Arg 
            20                  25                  30          


Leu Ser Trp Thr Trp Lys Met Gly Val Phe Tyr Ala Pro Gly Gln Gly 
        35                  40                  45              


Thr Asn Phe Tyr Ser Leu Val Leu Gln Cys Ile Gln Val Lys Cys His 
    50                  55                  60                  


Ser Gln Lys Tyr Glu Leu Phe Gln Val Ile Asp Val 
65                  70                  75      


<210>  8559
<211>  8058
<212>  DNA
<213>  Homosapiens

<400>  8559
gaagccttgt tggttgacgt cacttggttc atgaagcctt cgcctagaag tgaagctgct     60

gaacaaacct tgagaagaat catctcctgc ttcaatctgc tgctggatag gaactaatca    120

gagagagaga ggcggaagac ggagaaggag ggagtcgaag gctttcccga tcacaaatct    180

cacctccact acaactctct ttatactttt cttgcagaaa taataataga aataaggagg    240

tggtggggtt tccaaaaatc ttaaccttca accatctggg gaaaaggcaa aaatcccatc    300

taccgcaact ctcagttcga gagtaaaggt ttcccaacag tgatgtcaca agattgacca    360

cattgatcac aatatggagt ctggagaacg gttaccatcc tcagcagcct cctctactac    420

accaacttca tcttcgacac cttctgtggc ttcagtagtt tcaaaaggtg gcctttccac    480

tggagttgct tcacttagct ctacaatcaa cccatgtgga catttattca gaacagctgg    540

ggatcaaccg tttaacctgt ccacagtgtc gagtgccttc ccaatggtca gccacccagt    600

ctttggtcta cattcagcca gctcagggca ttcagaattt ggtggtttgg ggacacttgg    660

tacacccaca gccttagccg cacatcccca actagcatct tttccagaat ggtggcgaac    720

aactgatgct catactcgta caggagcaac cttctttcca ccattactgg gaattccacc    780

actatttgct cccccagccc agaatcatga ttcttcttca ttccattcaa ggacttcggg    840

aaaaagtaat cgaaatggtc ccgaaaaagg tgtaaatggg tcaataaatg gaagtaatac    900

atcatctgta attggtatca acacatctgt actatccact actgcttcaa gttccatggg    960

acaaactaaa agtacaagct caggtggagg aaatcgaaaa tgtaatcagg aacaaagcaa   1020

aaaccagcct ttggatgcta gagttgacaa aatcaaagat aagaaaccaa ggaagaaagc   1080

aatggaaagt tctagcaaca gtgatagtga ttcaggcaca tcatcagaca cctcaagtga   1140

aggcattagt agcagtgatt cagatgatct agaagaagat gaagaagaag aagatcaaag   1200

tattgaagaa agtgaagatg atgattctga ttcagagagt gaagcacaac ataaaagtaa   1260

caaccaggtg ctattacatg gtatttcaga cccaaaagca gatggacaga aagcaactga   1320

aaaagcccag gaaaaaagaa tacaccagcc attacctctt gcgtctgaat cccagactca   1380

ctcattccaa tcccagcaga agcagcctca ggttttgtca cagcagcttc catttatttt   1440

ccaaagctct caggcaaagg aggaatctgt gaacaaacac accagtgtaa tacagtctac   1500

gggattggtg tccaatgtga aacctttatc tttggtaaat caagccaaaa aggaaactta   1560

catgaaactc atagttcctt ctcctgatgt tcttaaagca gggaataaaa atacctctga   1620

agaatctagt ttattgacca gtgaattgag atccaaacgg gaacaatata aacaggcatt   1680

cccatcacag ttaaagaaac aagagtcatc gaagagcctg aagaaggtta ttgcagcttt   1740

gtcaaatcca aaagcaacct ctagttcacc agcacatcca aaacaaacat tagaaaacaa   1800

ccacccaaat ccattcttga caaatgcact tttaggtaat caccaaccaa atggagttat   1860

tcaaagtgtc attcaagaag ctcctctagc acttactacc aaaactaaaa tgcagagcaa   1920

gattaatgaa aacattgctg ctgcaagtag cacccctttt tcctcacctg taaatctgag   1980

tacaagtggg agaagaaccc ctggcaatca gacacctgta atgccctctg cctctcccat   2040

cctgcatagt caagggaagg aaaaagcagt tagcaataat gtaaacccag taaaaacaca   2100

gcatcactcc catcctgcaa aatctttagt ggaacaattc agaggaacag attcagacat   2160

tcccagtagt aaagattctg aagattcaaa tgaggatgaa gaggaagatg atgaagaaga   2220

agatgaggaa gatgatgaag atgatgaatc tgatgacagc caatcagaat cagatagtaa   2280

ttcagaatca gatacagaag gatcagaaga agaagatgat gatgataaag accaagatga   2340

atcagatagt gatactgaag gagagaaaac ttcaatgaaa ctgaataaaa caacttcctc   2400

tgtcaaaagc ccttccatga gtctcacagg tcactcaaca cctcgtaacc tccacatagc   2460

aaaagcccca ggctctgctc ctgctgcctt atgttctgaa tcccagtcac ctgcttttct   2520

tggtacatct tcttccacac ttacttcaag cccacactct ggcacttcca aaagaagaag   2580

agtaacagat gaacgtgaac tgcgtattcc attggaatat ggctggcaga gagagacaag   2640

aataagaaac tttggagggc gccttcaagg agaagtagca tattatgctc catgtggaaa   2700

gaaacttagg cagtaccctg aagtaataaa gggaatgcag tggtgtcttt tgaaagaaga   2760

ggatgtcatt cctcgtatca gggcaatgga aggtcgtaga ggaagaccac caaatccaga   2820

tagacaacga gcaagagagg aatccaggat gagacgtcgg aaaggtcgac ctccaaatgt   2880

tggcaatgct gaattcctag ataacgcaga tgcaaagttg ctaagaaaac tgcaagctca   2940

agaaatagcc aggcaagcag cacaaataaa gcttttgaga aaacttcaaa agcaggaaca   3000

ggctcgggtt gctaaagaag ccaaaaaaca acaagcaata atggctgctg aggagaagcg   3060

gaagcaaaaa gaacagataa agattatgaa acagcaggaa aaaattaaga gaatacagca   3120

aatcagaatg gaaaaagaac ttcgagctca gcaaattcta gaggctaaaa agaaaaagaa   3180

ggaagaagcg gcaaatgcca aattattgga ggccgagaaa cgaataaagg aaaaagaaat   3240

gagaagacaa caagctgttc ttctgaaaca tcaggaacga gagcgaaggc gacaacacat   3300

gatgcttatg aaagctatgg aagctcgtaa aaaagcagaa gaaaaagagc ggttgaaaca   3360

agaaaaacgt gatgagaaaa gattaaataa agagcgtaaa ctagagcagc gaagattaga   3420

attagaaatg gcaaaggaac taaagaagcc taatgaagac atgtgcttag cagaccaaaa   3480

gcctttgcca gagttgcctc gtattccagg acttgttctc tctggaagta cattttcaga   3540

ctgtctcatg gtggtgcagt tcttacgaaa ctttggtaaa gttttgggct ttgatgtgaa   3600

tattgatgtt ccaaacctga gtgttcttca agagggattg ctaaatatag gggacagcat   3660

gggtgaagta caagacttgc ttgtgaggct cctctcagct gctgtatgtg atccaggtct   3720

aataacagga tacaaggcta aaacagctct tggagaacat ttgctgaatg ttggtgtgaa   3780

tcgagacaat gtttccgaga ttttacagat atttatggaa gcccactgtg gacaaactga   3840

gcttactgaa agtctgaaga ccaaagcttt tcaggctcac actccagcac agaaagcttc   3900

agtcctggct ttcctgatca atgaactggc atgcagcaag agtgtggtca gtgaaatcga   3960

caagaacatt gattatatgt caaacttgag gagagataaa tgggtggtag aaggtaaact   4020

ccgcaagctc agaatcattc atgctaagaa aacaggcaaa agagacactt caggtggcat   4080

tgatctggga gaagagcagc atcccttggg cacacccact ccaggacgca agcgaagaag   4140

gaagggagga gacagtgatt atgacgatga tgatgacgat gacagtgatg accaagggga   4200

tgaagatgat gaggatgaag aagataaaga agacaaaaaa ggaaaaaaga ctgatatctg   4260

tgaagatgag gatgaaggtg accaagcagc aagtgttgaa gagctggaaa aacagattga   4320

aaaactgagt aaacaacaga gtcagtacag aaggaagctc tttgatgcgt ctcactcatt   4380

gcgttcagtg atgtttggcc aagatcgtta cagacgccgg tactggattc ttccccaatg   4440

tggggggatt tttgtagaag gcatggagag tggtgaagga ctagaagaaa ttgcaaaaga   4500

aagagaaaaa ctgaaaaagg cagaaagtgt ccagatcaaa gaagaaatgt ttgagacttc   4560

tggggacagt ttaaattgtt caaatacaga tcactgtgaa caaaaggaag atcttaaaga   4620

aaaagataac acaaatctat tccttcagaa acctggctct ttttccaaat taagcaagct   4680

tttggaagta gctaagatgc ctcctgagtc agaggttatg acccccaaac caaatgctgg   4740

tgcaaatggg tgcacgttgt cttatcagaa cagtggaaaa cattcactgg gcagcgttca   4800

gtcaacagca acgcaaagca atgtggaaaa ggcagactct aataatctgt ttaatactgg   4860

ttcaagtggt ccagggaagt tctacagtcc tctccccaat gaccagttac taaaaacgct   4920

gactgaaaag aatagacaat ggtttagtct tttgccacga acaccctgtg atgacacttc   4980

acttactcat gccgatatgt caactgcttc tttggtgact cctcagtctc agccaccatc   5040

taagtcacct tcacctaccc cagctcctct tggatcttct gctcagaatc ctgttggctt   5100

aaatccattt gctttatcac ctcttcaggt gaaaggtgga gtatctatga tgggacttca   5160

gttttgtgga tggcccactg gtgtggttac ttctaatatt ccatttacat catctgtacc   5220

tagtctagga tcggggttag ggttatcaga aggaaatggt aattcattct tgacttccaa   5280

tgttgcttca agtaaaagtg aatctccagt accacagaat gaaaaggcca cttcagctca   5340

acctgcagct gttgaagtag caaaaccagt agattttcct agtccaaaac ctattccaga   5400

agaaatgcag tttggttggt ggagaattat tgacccagag gacctaaaag ctttgctcaa   5460

agtgctgcat ctcagaggaa taagagaaaa ggcattacaa aaacaaattc agaaacattt   5520

ggattatatt actcaagcct gcctcaagaa taaggatgtt gctattattg aactgaatga   5580

aaatgaagaa aaccaagtaa ctcgagatat tgtggagaac tggtcagtag aagaacaagc   5640

aatggaaatg gatttgagtg tccttcaaca ggtagaagat ctagaaagga gagttgcatc   5700

agcaagtttg caagtgaagg gttggatgtg tccagagcct gcatcagaaa gggaggactt   5760

ggtatatttt gaacataaat catttactaa attgtgcaag gagcatgatg gagaatttac   5820

tggcgaagac gaaagcagtg cacatgcact agaacggaag agtgacaacc ccctagatat   5880

agctgtaacc aggctggctg atttggagcg gaacattgaa agaagaattg aagaggatat   5940

tgctccaggg ctcagggtat ggagaagggc attatcagaa gctcgcagtg ctgcacaggt   6000

agctctgtgc attcagcaat tacagaaatc aatagcatgg gaaaaatcaa ttatgaaagt   6060

ttactgccaa atctgtcgaa agggagataa tgaagaactg cttcttcttt gtgatggctg   6120

tgacaaaggc tgtcatacct actgccatag acccaagatt acaacaatcc cagatggaga   6180

ctggttttgt ccagcttgca ttgctaaggc aagtggtcaa actctaaaaa tcaaaaaact   6240

tcatgtcaaa ggaaaaaaga ctaatgagtc aaagaaaggc aagaaggtaa ctttaacagg   6300

agatactgaa gatgaagact ctgcatctac aagtagttca ctaaaaagag gaaacaaaga   6360

cctcaagaaa agaaaaatgg aggaaaacac ttctattaac ttgtcaaaac aagaaagttt   6420

tacttcagtt aagaaaccta aaagagatga ctccaaggac ctagctcttt gcagtatgat   6480

tctgactgaa atggaaactc atgaggatgc atggcctttt ctacttcctg taaacttgaa   6540

acttgttcct ggttataaga aagttattaa gaagcctatg gatttttcca caattagaga   6600

gaaactaagt agtggacagt atccaaacct tgaaaccttt gctctagatg tcaggcttgt   6660

ttttgacaac tgtgaaacat ttaatgaaga tgattctgat ataggcagag ctggccacaa   6720

tatgaggaag tattttgaaa aaaagtggac agatactttc aaagtgagct gaagttataa   6780

taatctcttt atttttttcc ttctaaacaa ggacaaatga gaccagcaat gtgaactgta   6840

tttacataaa cgtgcaaggc acatacataa tgactttctt tttccttaag tataaaaaaa   6900

aagtatcaga agaatgatac catttttaaa ggcttcattc ctacaacaac caaggccctc   6960

ggttattggt ttgtgtgatt tatcagctaa tttaggtaga acagggaagc acacccaaag   7020

aattttcaaa ggaaagggtg ttatagtgca atagcaatta aaatatatca aatcgcactg   7080

aatactcaac accagagctc taatgtggga aatggttctc ctttccctct caataaatat   7140

ctatttttca tttttttact ttgtagttta ttttttagtg aatgtattta attttatgaa   7200

ttatttatga ttaaaccaca tccagaatct tcgttttctg tgaaaaggaa gaactagaaa   7260

attgctttaa atcttgaaaa tacaaggaat gttttaaaat ataaaacaaa gccaagttaa   7320

actgtttaca ctgatgtgct ataaaagcac caaaaagaaa ctttactgta gagttacaag   7380

tacatttata tatatatgtt gctgcatcac ttgtgtagtt aaattgtatt tcaaaacagt   7440

gaaaaaattg acatgtatat actgttcatt cttgtttata ttaagtcttg ttttaaatat   7500

gtattatgtg tatatattgt ttgcagacat tattgttcat gccttagagg attgtagcat   7560

tttattttcg tctgaaggta atgatagcta tacagtctgt acagtaatta tcctctacca   7620

acactgtggc gtctccttaa tcttggtagt gcctgccttt gaaacagggt gtaggggata   7680

ttagttttcc atttttctat tttgttatat aattttaagc caccagggcc taaattaaag   7740

tataatcatt tgtatccatg tggaataaaa ttgtgacaat ttcctacgca cacagtattt   7800

tttcatagaa acatttccct cccatttgcc ttgcctcaga aataaattta aaagacgttt   7860

gtaaccactg tgttttatct actgtgtgtt gtggtggcct gttggaggca aatagatcag   7920

attttttttg tacctacgta agagtacttg aagttttatt taaaataaaa tgttgtggaa   7980

aaggtagcat tcttttttta ggagtgttat ttttcactat gtgtggcacg gatacaataa   8040

aagactttta caaactaa                                                 8058


<210>  8560
<211>  2132
<212>  PRT
<213>  Homosapiens

<400>  8560

Met Glu Ser Gly Glu Arg Leu Pro Ser Ser Ala Ala Ser Ser Thr Thr 
1               5                   10                  15      


Pro Thr Ser Ser Ser Thr Pro Ser Val Ala Ser Val Val Ser Lys Gly 
            20                  25                  30          


Gly Leu Ser Thr Gly Val Ala Ser Leu Ser Ser Thr Ile Asn Pro Cys 
        35                  40                  45              


Gly His Leu Phe Arg Thr Ala Gly Asp Gln Pro Phe Asn Leu Ser Thr 
    50                  55                  60                  


Val Ser Ser Ala Phe Pro Met Val Ser His Pro Val Phe Gly Leu His 
65                  70                  75                  80  


Ser Ala Ser Ser Gly His Ser Glu Phe Gly Gly Leu Gly Thr Leu Gly 
                85                  90                  95      


Thr Pro Thr Ala Leu Ala Ala His Pro Gln Leu Ala Ser Phe Pro Glu 
            100                 105                 110         


Trp Trp Arg Thr Thr Asp Ala His Thr Arg Thr Gly Ala Thr Phe Phe 
        115                 120                 125             


Pro Pro Leu Leu Gly Ile Pro Pro Leu Phe Ala Pro Pro Ala Gln Asn 
    130                 135                 140                 


His Asp Ser Ser Ser Phe His Ser Arg Thr Ser Gly Lys Ser Asn Arg 
145                 150                 155                 160 


Asn Gly Pro Glu Lys Gly Val Asn Gly Ser Ile Asn Gly Ser Asn Thr 
                165                 170                 175     


Ser Ser Val Ile Gly Ile Asn Thr Ser Val Leu Ser Thr Thr Ala Ser 
            180                 185                 190         


Ser Ser Met Gly Gln Thr Lys Ser Thr Ser Ser Gly Gly Gly Asn Arg 
        195                 200                 205             


Lys Cys Asn Gln Glu Gln Ser Lys Asn Gln Pro Leu Asp Ala Arg Val 
    210                 215                 220                 


Asp Lys Ile Lys Asp Lys Lys Pro Arg Lys Lys Ala Met Glu Ser Ser 
225                 230                 235                 240 


Ser Asn Ser Asp Ser Asp Ser Gly Thr Ser Ser Asp Thr Ser Ser Glu 
                245                 250                 255     


Gly Ile Ser Ser Ser Asp Ser Asp Asp Leu Glu Glu Asp Glu Glu Glu 
            260                 265                 270         


Glu Asp Gln Ser Ile Glu Glu Ser Glu Asp Asp Asp Ser Asp Ser Glu 
        275                 280                 285             


Ser Glu Ala Gln His Lys Ser Asn Asn Gln Val Leu Leu His Gly Ile 
    290                 295                 300                 


Ser Asp Pro Lys Ala Asp Gly Gln Lys Ala Thr Glu Lys Ala Gln Glu 
305                 310                 315                 320 


Lys Arg Ile His Gln Pro Leu Pro Leu Ala Ser Glu Ser Gln Thr His 
                325                 330                 335     


Ser Phe Gln Ser Gln Gln Lys Gln Pro Gln Val Leu Ser Gln Gln Leu 
            340                 345                 350         


Pro Phe Ile Phe Gln Ser Ser Gln Ala Lys Glu Glu Ser Val Asn Lys 
        355                 360                 365             


His Thr Ser Val Ile Gln Ser Thr Gly Leu Val Ser Asn Val Lys Pro 
    370                 375                 380                 


Leu Ser Leu Val Asn Gln Ala Lys Lys Glu Thr Tyr Met Lys Leu Ile 
385                 390                 395                 400 


Val Pro Ser Pro Asp Val Leu Lys Ala Gly Asn Lys Asn Thr Ser Glu 
                405                 410                 415     


Glu Ser Ser Leu Leu Thr Ser Glu Leu Arg Ser Lys Arg Glu Gln Tyr 
            420                 425                 430         


Lys Gln Ala Phe Pro Ser Gln Leu Lys Lys Gln Glu Ser Ser Lys Ser 
        435                 440                 445             


Leu Lys Lys Val Ile Ala Ala Leu Ser Asn Pro Lys Ala Thr Ser Ser 
    450                 455                 460                 


Ser Pro Ala His Pro Lys Gln Thr Leu Glu Asn Asn His Pro Asn Pro 
465                 470                 475                 480 


Phe Leu Thr Asn Ala Leu Leu Gly Asn His Gln Pro Asn Gly Val Ile 
                485                 490                 495     


Gln Ser Val Ile Gln Glu Ala Pro Leu Ala Leu Thr Thr Lys Thr Lys 
            500                 505                 510         


Met Gln Ser Lys Ile Asn Glu Asn Ile Ala Ala Ala Ser Ser Thr Pro 
        515                 520                 525             


Phe Ser Ser Pro Val Asn Leu Ser Thr Ser Gly Arg Arg Thr Pro Gly 
    530                 535                 540                 


Asn Gln Thr Pro Val Met Pro Ser Ala Ser Pro Ile Leu His Ser Gln 
545                 550                 555                 560 


Gly Lys Glu Lys Ala Val Ser Asn Asn Val Asn Pro Val Lys Thr Gln 
                565                 570                 575     


His His Ser His Pro Ala Lys Ser Leu Val Glu Gln Phe Arg Gly Thr 
            580                 585                 590         


Asp Ser Asp Ile Pro Ser Ser Lys Asp Ser Glu Asp Ser Asn Glu Asp 
        595                 600                 605             


Glu Glu Glu Asp Asp Glu Glu Glu Asp Glu Glu Asp Asp Glu Asp Asp 
    610                 615                 620                 


Glu Ser Asp Asp Ser Gln Ser Glu Ser Asp Ser Asn Ser Glu Ser Asp 
625                 630                 635                 640 


Thr Glu Gly Ser Glu Glu Glu Asp Asp Asp Asp Lys Asp Gln Asp Glu 
                645                 650                 655     


Ser Asp Ser Asp Thr Glu Gly Glu Lys Thr Ser Met Lys Leu Asn Lys 
            660                 665                 670         


Thr Thr Ser Ser Val Lys Ser Pro Ser Met Ser Leu Thr Gly His Ser 
        675                 680                 685             


Thr Pro Arg Asn Leu His Ile Ala Lys Ala Pro Gly Ser Ala Pro Ala 
    690                 695                 700                 


Ala Leu Cys Ser Glu Ser Gln Ser Pro Ala Phe Leu Gly Thr Ser Ser 
705                 710                 715                 720 


Ser Thr Leu Thr Ser Ser Pro His Ser Gly Thr Ser Lys Arg Arg Arg 
                725                 730                 735     


Val Thr Asp Glu Arg Glu Leu Arg Ile Pro Leu Glu Tyr Gly Trp Gln 
            740                 745                 750         


Arg Glu Thr Arg Ile Arg Asn Phe Gly Gly Arg Leu Gln Gly Glu Val 
        755                 760                 765             


Ala Tyr Tyr Ala Pro Cys Gly Lys Lys Leu Arg Gln Tyr Pro Glu Val 
    770                 775                 780                 


Ile Lys Gly Met Gln Trp Cys Leu Leu Lys Glu Glu Asp Val Ile Pro 
785                 790                 795                 800 


Arg Ile Arg Ala Met Glu Gly Arg Arg Gly Arg Pro Pro Asn Pro Asp 
                805                 810                 815     


Arg Gln Arg Ala Arg Glu Glu Ser Arg Met Arg Arg Arg Lys Gly Arg 
            820                 825                 830         


Pro Pro Asn Val Gly Asn Ala Glu Phe Leu Asp Asn Ala Asp Ala Lys 
        835                 840                 845             


Leu Leu Arg Lys Leu Gln Ala Gln Glu Ile Ala Arg Gln Ala Ala Gln 
    850                 855                 860                 


Ile Lys Leu Leu Arg Lys Leu Gln Lys Gln Glu Gln Ala Arg Val Ala 
865                 870                 875                 880 


Lys Glu Ala Lys Lys Gln Gln Ala Ile Met Ala Ala Glu Glu Lys Arg 
                885                 890                 895     


Lys Gln Lys Glu Gln Ile Lys Ile Met Lys Gln Gln Glu Lys Ile Lys 
            900                 905                 910         


Arg Ile Gln Gln Ile Arg Met Glu Lys Glu Leu Arg Ala Gln Gln Ile 
        915                 920                 925             


Leu Glu Ala Lys Lys Lys Lys Lys Glu Glu Ala Ala Asn Ala Lys Leu 
    930                 935                 940                 


Leu Glu Ala Glu Lys Arg Ile Lys Glu Lys Glu Met Arg Arg Gln Gln 
945                 950                 955                 960 


Ala Val Leu Leu Lys His Gln Glu Arg Glu Arg Arg Arg Gln His Met 
                965                 970                 975     


Met Leu Met Lys Ala Met Glu Ala Arg Lys Lys Ala Glu Glu Lys Glu 
            980                 985                 990         


Arg Leu Lys Gln Glu Lys Arg Asp  Glu Lys Arg Leu Asn  Lys Glu Arg 
        995                 1000                 1005             


Lys Leu  Glu Gln Arg Arg Leu  Glu Leu Glu Met Ala  Lys Glu Leu 
    1010                 1015                 1020             


Lys Lys  Pro Asn Glu Asp Met  Cys Leu Ala Asp Gln  Lys Pro Leu 
    1025                 1030                 1035             


Pro Glu  Leu Pro Arg Ile Pro  Gly Leu Val Leu Ser  Gly Ser Thr 
    1040                 1045                 1050             


Phe Ser  Asp Cys Leu Met Val  Val Gln Phe Leu Arg  Asn Phe Gly 
    1055                 1060                 1065             


Lys Val  Leu Gly Phe Asp Val  Asn Ile Asp Val Pro  Asn Leu Ser 
    1070                 1075                 1080             


Val Leu  Gln Glu Gly Leu Leu  Asn Ile Gly Asp Ser  Met Gly Glu 
    1085                 1090                 1095             


Val Gln  Asp Leu Leu Val Arg  Leu Leu Ser Ala Ala  Val Cys Asp 
    1100                 1105                 1110             


Pro Gly  Leu Ile Thr Gly Tyr  Lys Ala Lys Thr Ala  Leu Gly Glu 
    1115                 1120                 1125             


His Leu  Leu Asn Val Gly Val  Asn Arg Asp Asn Val  Ser Glu Ile 
    1130                 1135                 1140             


Leu Gln  Ile Phe Met Glu Ala  His Cys Gly Gln Thr  Glu Leu Thr 
    1145                 1150                 1155             


Glu Ser  Leu Lys Thr Lys Ala  Phe Gln Ala His Thr  Pro Ala Gln 
    1160                 1165                 1170             


Lys Ala  Ser Val Leu Ala Phe  Leu Ile Asn Glu Leu  Ala Cys Ser 
    1175                 1180                 1185             


Lys Ser  Val Val Ser Glu Ile  Asp Lys Asn Ile Asp  Tyr Met Ser 
    1190                 1195                 1200             


Asn Leu  Arg Arg Asp Lys Trp  Val Val Glu Gly Lys  Leu Arg Lys 
    1205                 1210                 1215             


Leu Arg  Ile Ile His Ala Lys  Lys Thr Gly Lys Arg  Asp Thr Ser 
    1220                 1225                 1230             


Gly Gly  Ile Asp Leu Gly Glu  Glu Gln His Pro Leu  Gly Thr Pro 
    1235                 1240                 1245             


Thr Pro  Gly Arg Lys Arg Arg  Arg Lys Gly Gly Asp  Ser Asp Tyr 
    1250                 1255                 1260             


Asp Asp  Asp Asp Asp Asp Asp  Ser Asp Asp Gln Gly  Asp Glu Asp 
    1265                 1270                 1275             


Asp Glu  Asp Glu Glu Asp Lys  Glu Asp Lys Lys Gly  Lys Lys Thr 
    1280                 1285                 1290             


Asp Ile  Cys Glu Asp Glu Asp  Glu Gly Asp Gln Ala  Ala Ser Val 
    1295                 1300                 1305             


Glu Glu  Leu Glu Lys Gln Ile  Glu Lys Leu Ser Lys  Gln Gln Ser 
    1310                 1315                 1320             


Gln Tyr  Arg Arg Lys Leu Phe  Asp Ala Ser His Ser  Leu Arg Ser 
    1325                 1330                 1335             


Val Met  Phe Gly Gln Asp Arg  Tyr Arg Arg Arg Tyr  Trp Ile Leu 
    1340                 1345                 1350             


Pro Gln  Cys Gly Gly Ile Phe  Val Glu Gly Met Glu  Ser Gly Glu 
    1355                 1360                 1365             


Gly Leu  Glu Glu Ile Ala Lys  Glu Arg Glu Lys Leu  Lys Lys Ala 
    1370                 1375                 1380             


Glu Ser  Val Gln Ile Lys Glu  Glu Met Phe Glu Thr  Ser Gly Asp 
    1385                 1390                 1395             


Ser Leu  Asn Cys Ser Asn Thr  Asp His Cys Glu Gln  Lys Glu Asp 
    1400                 1405                 1410             


Leu Lys  Glu Lys Asp Asn Thr  Asn Leu Phe Leu Gln  Lys Pro Gly 
    1415                 1420                 1425             


Ser Phe  Ser Lys Leu Ser Lys  Leu Leu Glu Val Ala  Lys Met Pro 
    1430                 1435                 1440             


Pro Glu  Ser Glu Val Met Thr  Pro Lys Pro Asn Ala  Gly Ala Asn 
    1445                 1450                 1455             


Gly Cys  Thr Leu Ser Tyr Gln  Asn Ser Gly Lys His  Ser Leu Gly 
    1460                 1465                 1470             


Ser Val  Gln Ser Thr Ala Thr  Gln Ser Asn Val Glu  Lys Ala Asp 
    1475                 1480                 1485             


Ser Asn  Asn Leu Phe Asn Thr  Gly Ser Ser Gly Pro  Gly Lys Phe 
    1490                 1495                 1500             


Tyr Ser  Pro Leu Pro Asn Asp  Gln Leu Leu Lys Thr  Leu Thr Glu 
    1505                 1510                 1515             


Lys Asn  Arg Gln Trp Phe Ser  Leu Leu Pro Arg Thr  Pro Cys Asp 
    1520                 1525                 1530             


Asp Thr  Ser Leu Thr His Ala  Asp Met Ser Thr Ala  Ser Leu Val 
    1535                 1540                 1545             


Thr Pro  Gln Ser Gln Pro Pro  Ser Lys Ser Pro Ser  Pro Thr Pro 
    1550                 1555                 1560             


Ala Pro  Leu Gly Ser Ser Ala  Gln Asn Pro Val Gly  Leu Asn Pro 
    1565                 1570                 1575             


Phe Ala  Leu Ser Pro Leu Gln  Val Lys Gly Gly Val  Ser Met Met 
    1580                 1585                 1590             


Gly Leu  Gln Phe Cys Gly Trp  Pro Thr Gly Val Val  Thr Ser Asn 
    1595                 1600                 1605             


Ile Pro  Phe Thr Ser Ser Val  Pro Ser Leu Gly Ser  Gly Leu Gly 
    1610                 1615                 1620             


Leu Ser  Glu Gly Asn Gly Asn  Ser Phe Leu Thr Ser  Asn Val Ala 
    1625                 1630                 1635             


Ser Ser  Lys Ser Glu Ser Pro  Val Pro Gln Asn Glu  Lys Ala Thr 
    1640                 1645                 1650             


Ser Ala  Gln Pro Ala Ala Val  Glu Val Ala Lys Pro  Val Asp Phe 
    1655                 1660                 1665             


Pro Ser  Pro Lys Pro Ile Pro  Glu Glu Met Gln Phe  Gly Trp Trp 
    1670                 1675                 1680             


Arg Ile  Ile Asp Pro Glu Asp  Leu Lys Ala Leu Leu  Lys Val Leu 
    1685                 1690                 1695             


His Leu  Arg Gly Ile Arg Glu  Lys Ala Leu Gln Lys  Gln Ile Gln 
    1700                 1705                 1710             


Lys His  Leu Asp Tyr Ile Thr  Gln Ala Cys Leu Lys  Asn Lys Asp 
    1715                 1720                 1725             


Val Ala  Ile Ile Glu Leu Asn  Glu Asn Glu Glu Asn  Gln Val Thr 
    1730                 1735                 1740             


Arg Asp  Ile Val Glu Asn Trp  Ser Val Glu Glu Gln  Ala Met Glu 
    1745                 1750                 1755             


Met Asp  Leu Ser Val Leu Gln  Gln Val Glu Asp Leu  Glu Arg Arg 
    1760                 1765                 1770             


Val Ala  Ser Ala Ser Leu Gln  Val Lys Gly Trp Met  Cys Pro Glu 
    1775                 1780                 1785             


Pro Ala  Ser Glu Arg Glu Asp  Leu Val Tyr Phe Glu  His Lys Ser 
    1790                 1795                 1800             


Phe Thr  Lys Leu Cys Lys Glu  His Asp Gly Glu Phe  Thr Gly Glu 
    1805                 1810                 1815             


Asp Glu  Ser Ser Ala His Ala  Leu Glu Arg Lys Ser  Asp Asn Pro 
    1820                 1825                 1830             


Leu Asp  Ile Ala Val Thr Arg  Leu Ala Asp Leu Glu  Arg Asn Ile 
    1835                 1840                 1845             


Glu Arg  Arg Ile Glu Glu Asp  Ile Ala Pro Gly Leu  Arg Val Trp 
    1850                 1855                 1860             


Arg Arg  Ala Leu Ser Glu Ala  Arg Ser Ala Ala Gln  Val Ala Leu 
    1865                 1870                 1875             


Cys Ile  Gln Gln Leu Gln Lys  Ser Ile Ala Trp Glu  Lys Ser Ile 
    1880                 1885                 1890             


Met Lys  Val Tyr Cys Gln Ile  Cys Arg Lys Gly Asp  Asn Glu Glu 
    1895                 1900                 1905             


Leu Leu  Leu Leu Cys Asp Gly  Cys Asp Lys Gly Cys  His Thr Tyr 
    1910                 1915                 1920             


Cys His  Arg Pro Lys Ile Thr  Thr Ile Pro Asp Gly  Asp Trp Phe 
    1925                 1930                 1935             


Cys Pro  Ala Cys Ile Ala Lys  Ala Ser Gly Gln Thr  Leu Lys Ile 
    1940                 1945                 1950             


Lys Lys  Leu His Val Lys Gly  Lys Lys Thr Asn Glu  Ser Lys Lys 
    1955                 1960                 1965             


Gly Lys  Lys Val Thr Leu Thr  Gly Asp Thr Glu Asp  Glu Asp Ser 
    1970                 1975                 1980             


Ala Ser  Thr Ser Ser Ser Leu  Lys Arg Gly Asn Lys  Asp Leu Lys 
    1985                 1990                 1995             


Lys Arg  Lys Met Glu Glu Asn  Thr Ser Ile Asn Leu  Ser Lys Gln 
    2000                 2005                 2010             


Glu Ser  Phe Thr Ser Val Lys  Lys Pro Lys Arg Asp  Asp Ser Lys 
    2015                 2020                 2025             


Asp Leu  Ala Leu Cys Ser Met  Ile Leu Thr Glu Met  Glu Thr His 
    2030                 2035                 2040             


Glu Asp  Ala Trp Pro Phe Leu  Leu Pro Val Asn Leu  Lys Leu Val 
    2045                 2050                 2055             


Pro Gly  Tyr Lys Lys Val Ile  Lys Lys Pro Met Asp  Phe Ser Thr 
    2060                 2065                 2070             


Ile Arg  Glu Lys Leu Ser Ser  Gly Gln Tyr Pro Asn  Leu Glu Thr 
    2075                 2080                 2085             


Phe Ala  Leu Asp Val Arg Leu  Val Phe Asp Asn Cys  Glu Thr Phe 
    2090                 2095                 2100             


Asn Glu  Asp Asp Ser Asp Ile  Gly Arg Ala Gly His  Asn Met Arg 
    2105                 2110                 2115             


Lys Tyr  Phe Glu Lys Lys Trp  Thr Asp Thr Phe Lys  Val Ser 
    2120                 2125                 2130         


<210>  8561
<211>  2015
<212>  DNA
<213>  Homosapiens

<400>  8561
ctatgattta tattcaattt agaagagtta aatagaactt ataatgatca gcatccctca     60

catatatcaa ctgatttact agattgacca aatgacaaat ttatttcttt ggaggatgaa    120

ataacagccg tccaaaggtt tatgtctgtt ttgttttatt attttttaat tacagaaggg    180

acctgcctaa gttaaggaag cgtttaaatg attgattggt actgattggt tccaatatgc    240

aaacactgtt acctagatat ggactagttc ttttgtttgt tctttttttt tttttttgag    300

agagtttcac ttttgttgcc caagctggag tgcagtggtg catctcggct cactgcaatc    360

tctgcctccc gggttcaagt gattctcctg cctcagctac tcagggatga ggcacaagaa    420

tcacttgaaa ctggaggtgc aggttgcagt gagttacctc gccactgcac tccagcctgg    480

gcaacagagt gagattgtct caaaaaaaaa aaaaaaagct acaaaatcag agctcctttg    540

aaaaatgagt cccagtgaat ggaggaagtc acaggggaag agaaagagag aaggaaacag    600

tctgtgtatt cctgtttgtg atgccaggtg tgtgggaagc aaaatttcag tggattcaag    660

ctcctcgaac tctccacttt gagttgtttg attaaaccca aattaatgag ttggaaccaa    720

aactcacaaa ccatatttca aatttttaaa ctagaaattt ttagaataga gggaggggcc    780

tacttacatg aatttttctg agttccatta gctgccccat cccataaagg aaggacacac    840

atatgagttg tatacttttt tcacctagaa tctcacctag aattctctcc tggactccac    900

tctccctaat gttaatcatt aaccttttct tagggtaagg aacaaaggca gaagtagttc    960

tcaaatcaac tttaaaatat tttgtaaaaa tcattcccac acagattgta tgattccatt   1020

tagatgaagt atctggaata gataaatcca tagagacaga tagaagattg gtggttgcca   1080

ggtactggga agagggagga atggggaata actgtttaat gagtatgatg tttcctttca   1140

gggtgatgac agtgttttag aagtgacgat aatacagtgt tgtgacttaa atgccactga   1200

actgtccacc ttaatatggt taattttatg tgaatttctt aacctcagta aaaataagca   1260

agtaattcct aggaaaatgg atgaggttac ataagggctg acttaactct gtgagcacat   1320

tacgcataga gaaatatttc tttcattatc gcacagaaga agcgagtgaa aggtcataca   1380

agatatttca ccaaagaaat agaattccac tttgacaaga tctcacagcg tcagtgcctc   1440

atagggtatt tctctttttt taatttttat tttaattttt gcaggtacac agtaggtgta   1500

tatatttatg gactacatga gatacaggca tgcaatgcat aataatcaca tcatggaaaa   1560

ttgggtattc atcacctcaa gcatttatcc tttgtgttac agataatcca cttctactct   1620

tttacttatt ttaaagtgta caattaaact atgattgact atagtctcct tgttgtgctg   1680

tcacatacta ggtcttattc attccttcta tttttttgta cccattaact atccccacct   1740

ccccactgca gttcccagcc tctggtaacc atccttctac tctgtttcca tgagctcaat   1800

tgttttgatt tttagatccc acaaataagt gagaacacgt gatgtttgtg tttctgtgcc   1860

tggcttattt cacttaatat aatgacctcc agtttgatcc acgttgtttc aaatgacaaa   1920

atctcattct ttttttatgg ctgaatggtg cgccattgtg tttaagtacc atgttttctt   1980

tatccattcg tctgttgatg gacacttaga ttgct                              2015


<210>  8562
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  8562

Met Ser Pro Ser Glu Trp Arg Lys Ser Gln Gly Lys Arg Lys Arg Glu 
1               5                   10                  15      


Gly Asn Ser Leu Cys Ile Pro Val Cys Asp Ala Arg Cys Val Gly Ser 
            20                  25                  30          


Lys Ile Ser Val Asp Ser Ser Ser Ser Asn Ser Pro Leu 
        35                  40                  45  


<210>  8563
<211>  1045
<212>  DNA
<213>  Homosapiens

<400>  8563
ctaatgtcat gttaattatt tcatatgtta atgtgtacat gcttctgaag tgtgtgcaag     60

gcattctgcc tctagctttg ttctttgcag tgtacttgaa atgtgcattt accccaatag    120

aactgctcac ccgtcatgtg gtccatatct gtgtaacgaa agatacatag atgtgtatgg    180

ctactgtata tttgtaagca agcggaatgt tcattactaa tataaattag gaattatggt    240

gtgtttaaca tcccaataac tattattcat ggcagagcgt taattttaaa tgatttttca    300

tgtattatag tactgccaaa tctgtcgaaa gggagataat gaagaactgc ttcttctttg    360

tgatggctgt gacaaaggct gtcataccta ctgccataga cccaagatta caacaatccc    420

agatggagac tggttttgtc cagcttgcat tgctaaggca agtggtcaaa ctctaaaaat    480

caaaaaactt catgtcaaag gaaaaaagac taatgagtca aagaaaggca agaaggtaac    540

tttaacagga gatactgaag atgaagactc tgcatctaca agtagttcac taaaaagagg    600

aaacaaagac ctcaagaaaa gaaaaatgga ggaaaacact tctattaact tgtcaaaaca    660

agaaagtttt acttcagtta agaaacctaa aagagatgac tccaaggacc tagctctttg    720

cagtatgatt ctgactgaaa tggaaactca tgaggatgca tggccttttc tacttcctgt    780

aaacttgaaa cttgttcctg gttataagaa agttattaag aagcctatgg atttttccac    840

aattagagag aaactaagta gtggacagta cacagtaggt gtatatattt atggactaca    900

tgagatacag gcatgcaatg cataataatc acatcatgga aaattgggta ttcatcacct    960

caagcattta tcctttgtgt tacagataat ccacttctac tcttttactt attttaaagt   1020

gtacaattaa actatgattg actat                                         1045


<210>  8564
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  8564

Met Glu Glu Asn Thr Ser Ile Asn Leu Ser Lys Gln Glu Ser Phe Thr 
1               5                   10                  15      


Ser Val Lys Lys Pro Lys Arg Asp Asp Ser Lys Asp Leu Ala Leu Cys 
            20                  25                  30          


Ser Met Ile Leu Thr Glu Met Glu Thr His Glu Asp Ala Trp Pro Phe 
        35                  40                  45              


Leu Leu Pro Val Asn Leu Lys Leu Val Pro Gly Tyr Lys Lys Val Ile 
    50                  55                  60                  


Lys Lys Pro Met Asp Phe Ser Thr Ile Arg Glu Lys Leu Ser Ser Gly 
65                  70                  75                  80  


Gln Tyr Thr Val Gly Val Tyr Ile Tyr Gly Leu His Glu Ile Gln Ala 
                85                  90                  95      


Cys Asn Ala 
            


<210>  8565
<211>  470
<212>  DNA
<213>  Homosapiens

<400>  8565
tgtttccctg aagaaaagaa ttgattctta aataacttag agttctttct ttcgtcttta     60

cctttatgct tagactactc aaggccttat taattccaca caaataaatt acgtttcttc    120

tatggttttt cactgcttcc taaaacatct atgaatctgc agtttcataa tgtgctggaa    180

tacagggtct ttctcaattc agattggaat ttactataat tttttttttt tttttttttg    240

agacagagtc tctgttgccc aggctggagt gcagtagcag aatctcagct cactacaacc    300

tcaatctcct gggttcaagc agttctcctg ccctcagcta ctccagaggc caaggcagga    360

tcatttgagc ccaagagttc gaggctgtag tgtgctgtga ttacacttga gaacagccac    420

tgcactatag cctgggcaac ataatgagac cttgtctgta aataaaactg               470


<210>  8566
<211>  65
<212>  PRT
<213>  Homosapiens

<400>  8566

Cys Ala Gly Ile Gln Gly Leu Ser Gln Phe Arg Leu Glu Phe Thr Ile 
1               5                   10                  15      


Ile Phe Phe Phe Phe Phe Phe Glu Thr Glu Ser Leu Leu Pro Arg Leu 
            20                  25                  30          


Glu Cys Ser Ser Arg Ile Ser Ala His Tyr Asn Leu Asn Leu Leu Gly 
        35                  40                  45              


Ser Ser Ser Ser Pro Ala Leu Ser Tyr Ser Arg Gly Gln Gly Arg Ile 
    50                  55                  60                  


Ile 
65  


<210>  8567
<211>  528
<212>  DNA
<213>  Homosapiens

<400>  8567
ggtgtgatta gggcttactg caacctcgac ctaccaagct caagtgattc tcccaactca     60

gcctccaaat tagttgggag gctgaggtgg aaggatcgct tgagcccagg agtttgagtc    120

cagcatgggc aacatagtga gatcctgtct ctaaagaaaa taaaagaagg tgctcaataa    180

atattccttg ataacgaaat aaaaggatga atttaattct ttcactaaca gtattcctta    240

gagaactttc caaaacatgt aactgtagct catctgtagt tcatttttgt gatcagctgc    300

acaattttgt tatataggta tatcataatt tatccaacca gtcctttatt aatgtttgac    360

atagccctca tatccttctc ttcaaattag tttctagttg aaattaaatc cctatacatc    420

agatttatac ttctgaccaa tatagagtaa cagggactag attaccttct tgtatgaaac    480

aaccagaaac agataaaata catgaaacaa cagtttgcag gaaactga                 528


<210>  8568
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  8568

Met Asn Leu Ile Leu Ser Leu Thr Val Phe Leu Arg Glu Leu Ser Lys 
1               5                   10                  15      


Thr Cys Asn Cys Ser Ser Ser Val Val His Phe Cys Asp Gln Leu His 
            20                  25                  30          


Asn Phe Val Ile 
        35      


<210>  8569
<211>  556
<212>  DNA
<213>  Homosapiens

<400>  8569
gacctggatc acatacagca gctgagagga gcctcacaag caagtcttgt acttcaccca     60

tgctgtcccc tatatttagc aatccctctt gaagaacact cagcctcact gtatgacaca    120

cctgtgtgga gaagacagca tagccccttt gaagttactg cttggatgat taatgacgat    180

gaagcaacaa caaagccaag acgggcatgt acactagcct gtgcatgcaa aacaggtctc    240

aaagtcatgc aacagcacca ctacaacttg caaataatgt cagacttgaa atgaagctac    300

atgtctcaca agtggcaact tttaagtaat cctgaaagca ttaagaagca atgaaggcaa    360

atcttatttt gtataacttg aatttaattt tctactaata ttttacatgt ttaagaaaaa    420

caagctttta ttaaaatttg aacattcgag caatatactt cattgactga tacattaatt    480

taaaaattct gaaaattgtt caagatatca acttatacaa agtctaccag gatattaaag    540

tacttacaca aattta                                                    556


<210>  8570
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  8570

Met Ile Asn Asp Asp Glu Ala Thr Thr Lys Pro Arg Arg Ala Cys Thr 
1               5                   10                  15      


Leu Ala Cys Ala Cys Lys Thr Gly Leu Lys Val Met Gln Gln His His 
            20                  25                  30          


Tyr Asn Leu Gln Ile Met Ser Asp Leu Lys 
        35                  40          


<210>  8571
<211>  283
<212>  DNA
<213>  Homosapiens

<400>  8571
tgggctcaca ggtggaatct taaaggcaca gtatgaaaat aagcagtggc aacttttaag     60

taatcctgaa agcattaaga agcaatgaag gcaaatctta ttttgtataa cttgaattta    120

attttctact aatattttac atgtttaaga aaaacaagct tttattaaaa tttgaacatt    180

cgagcaatat acttcattga ctgatacatt aatttaaaaa ttctgaaaat tgttcaagat    240

atcaacttat acaaagtcta ccaggatatt aaagtactta cac                      283


<210>  8572
<211>  6500
<212>  DNA
<213>  Homosapiens

<400>  8572
cggcggggac cgagagctgc gggcgggctg gaggtacccc accgcggggt ggtgctctga     60

ctgcgggaac cgttgaagag ctgcccccgg ggagtcagcg aggcgccact ggtctcttag    120

acatcttctc aagattatgc taagagaaat gactgcaccc ttttcctgag ctatggcagt    180

cagacctggc agtggtaact actctacaga actcccaaac ctggcaagga tggtgcagat    240

tttggcagat tatggctttg tccccaccca gcactgatga tattataaaa cctatactac    300

aagaaatgat aatggaagtt cttcaactga gcaagaaatg atattaacag aaaacttgga    360

tcttcagaag caaatgaaga acatcagaaa tgcaactttc attgttagag agaggagaga    420

gagagaagcc ttgttggttg acgtcacttg gttcatgaag ccttcgccta gaagtgaagc    480

tgctgaacaa accttgagaa gaatcatctc ctgcttcaat ctgctgctgg ataggaacta    540

atcagagaga gagaggcgga agacggagaa ggagggagtc gaaggctttc ccgatcacaa    600

atctcacctc cactacaact ctctttatac ttttcttgca gaaataataa tagaaataag    660

gaggtggtgg ggtttccaaa aatcttaacc ttcaaccatc tggggaaaag gcaaaaatcc    720

catctaccgc aactctcagt tcgagagtaa aggtttccca acagtgatgt cacaagattg    780

accacattga tcacaatatg gagtctggag aacggttacc atcctcagca gcctcctcta    840

ctacaccaac ttcatcttcg acaccttctg tggcttcagt agtttcaaaa ggtggccttt    900

ccactggagt tgcttcactt agctctacaa tcaacccatg tggacattta ttcagaacag    960

ctggggatca accgtttaac ctgtccacag tgtcgagtgc cttcccaatg gtcagccacc   1020

cagtctttgg tctacattca gccagctcag ggcattcaga atttggtggt ttggggacac   1080

ttggtacacc cacagcctta gccgcacatc cccaactagc atcttttcca gaatggtggc   1140

gaacaactga tgctcatact cgtacaggag caaccttctt tccaccatta ctgggaattc   1200

caccactatt tgctccccca gcccagaatc atgattcttc ttcattccat tcaaggactt   1260

cgggaaaaag taatcgaaat ggtcccgaaa aaggtgtaaa tgggtcaata aatggaagta   1320

atacatcatc tgtaattggt atcaacacat ctgtactatc cactactgct tcaagttcca   1380

tgggacaaac taaaagtaca agctcaggtg gaggaaatcg aaaatgtaat caggaacaaa   1440

gcaaaaacca gcctttggat gctagagttg acaaaatcaa agataagaaa ccaaggaaga   1500

aagcaatgga aagttctagc aacagtgata gtgattcagg cacatcatca gacacctcaa   1560

gtgaaggcat tagtagcagt gattcagatg atctagaaga agatgaagaa gaagaagatc   1620

aaagtattga agaaagtgaa gatgatgatt ctgattcaga gagtgaagca caacataaaa   1680

gtaacaacca ggtgctatta catggtattt cagacccaaa agcagatgga cagaaagcaa   1740

ctgaaaaagc ccaggaaaaa agaatacacc agccattacc tcttgcgtct gaatcccaga   1800

ctcactcatt ccaatcccag cagaagcagc ctcaggtttt gtcacagcag cttccattta   1860

ttttccaaag ctctcaggca aaggaggaat ctgtgaacaa acacaccagt gtaatacagt   1920

ctacgggatt ggtgtccaat gtgaaacctt tatctttggt aaatcaagcc aaaaaggaaa   1980

cttacatgaa actcatagtt ccttctcctg atgttcttaa agcagggaat aaaaatacct   2040

ctgaagaatc tagtttattg accagtgaat tgagatccaa acgggtgagt tacaaattat   2100

ttatacaaga attttactat tagagaaaga tagagcttct atattgtctt acaatacaca   2160

agtttaagtt aaattctacc ttcattttta tactttctta gtctccagga atagaatatg   2220

tacagcagaa aactaaattt ctctgatttt atattcatat atgtatctgt ttaatgtatt   2280

tttggcaatg caatcatgtc attccagctc cctgaaaccc catctttact aaaaatataa   2340

atattagctg ggcgtggtgg ggtgtgcctg tagttgcagc tactcaggag gctgaggcag   2400

gagaatcgtt tgagcccagg aggtggaggt tgcagtgagc caagatcgcg ccactgcact   2460

ccagcctggc aacagagtga gactctgtct caaaaaaaaa actaaaaaaa acaaaaacat   2520

tagccaggta tggtggcacg tgcccatagt ctcagctact caggaatctg aggcaggctt   2580

gaacccggga ggtgggggtt gctgcgagcc aagatcgtgc cactgcactc cagcctgggt   2640

gacagagtcc aaaaaaataa taataataaa atatttataa gtattttata taacattcca   2700

tcagcattta cacttgtgaa atctccatca caaatctttg ctgattttag tgttaggagc   2760

ccaggtctga tgctgacaac actactgatt ttaatttcaa ggcaatcatt ttcaatgcag   2820

aattttacct tagattaaga aattcagctc cttctgttaa ctcaaaggat tttaataatt   2880

ctgctgctgt taatttttat gtaatatttt aattatagta gcttaataaa attcatgatt   2940

gtgttgtttt caaggggatt ctaatagtta aataagtttt tgtttataga cataaatttt   3000

atggcttaat agtttataat cttttccaag aaaattgtat ttttctaaat tgtttactcg   3060

ggaatattac tgtgcaaagg cacactaaag tagatcccac agaatgttga atgtccattt   3120

ccaccagctt agtatcttaa atctttgctt caaagaagtt cttgctcagg aagttattca   3180

ttcagcaacc taaaattgtt ttttgagtac atatcaagca cagggttctg agcaatgtct   3240

taggaagacc ataaaggtga ataaatgagt gtttctaccc tgaggaattt atcaaagatg   3300

ttaagttatc tccttagagg tataagtcat ataggcatat tctatgtata ctaaaggtgg   3360

tatggcataa gagtacatat agtcaccaac ttagaattgt ttgacttggc cgggcgcagt   3420

ggctcacgcc tgtaatccca gcactttggg aggccaaggc aggtggatca cgaggtcaag   3480

agatcgagac tatcctggcc aacatggtgc aaccccatct ccactaaaaa tacaaaaatt   3540

acctaggcat ggtggtgcat gcctgtagtc ccagctactt gggaggctga ggcaggagaa   3600

tcacttgaac ccaggaggca gaggttgcag tgagccgaga tcgcgccact gcactccagc   3660

ctggtgacag agcaagactc catctcaaaa aataataata ataataataa taattctttg   3720

acttatgatc tttcaacttc acaatggagc gaatgctata cacattcagt agaaattggt   3780

acaataatcc cttgatgctg agcagcagca gtgagccaca gctcctggtc agccgcatga   3840

taacaagggc agacaactga tactctacag tttactgtgt tgataggtta ttttgctcaa   3900

ctttaggcta atgtaagtgt tttcagtaca tttaaggtag tttagactaa gctatgatgt   3960

ttggtaggtt aggtgtattg tatctatttt tgacttaatg atattttcaa ctttcgatga   4020

gtttatgggg aagtcacccc atggcaagct gaggagcatc tatataaaga ggtaaaagag   4080

ctcaaaggaa agaggcaaag aatgcttctg gctgggaaat ttggaaagct tcttggtttg   4140

gatcttgaag aataaacagt attttgtcag cttgaaattt ctaagaggag gctatttcat   4200

gcaaagaaaa tggttttaag tttggattat tgtgaaaatg gaagcaacag taaagagggg   4260

aggctagtca aaaggcatat aatttttaat ggggaaaaac taaataaatt ttaataaatt   4320

agagccaaaa tgtagcaacc aactagtcat agctgttgct acttttacag catttgtata   4380

tcatgattta aatttatata tgatataata gctataattt gttttcagat attgaaagca   4440

aataaaagca atctttgttt tgtggtacat tttgttgtgt tttttaactt atgtttcaac   4500

aggaacaata taaacaggca ttcccatcac agttaaagaa acaagagtca tcgaagagcc   4560

tgaagaaggt tattgcagct ttgtcaaatc caaaagcaac ctctagttca ccagcacatc   4620

caaaacaaac attagaaaac aaccacccaa atccattctt gacaaatgca cttttaggta   4680

atcaccaacc aaatggagtt attcaaagtg tcattcaaga agctcctcta gcacttacta   4740

ccaaaactaa aatgcagagc aagattaatg aaaacattgc tgctgcaagt agcacccctt   4800

tttcctcacc tgtaaatctg agtacaagtg ggagaagaac ccctggcaat cagacacctg   4860

taatgccctc tgcctctccc atcctgcata gtcaagggaa ggaaaaagca gttagcaata   4920

atgtaaaccc agtaaaaaca cagcatcact cccatcctgc aaaatcttta gtggaacaat   4980

tcagaggaac agattcagac attcccagta gtaaagattc tgaagattca aatgaggatg   5040

aagaggaaga tgatgaagaa gaagatgagg aagatgatga agatgatgaa tctgatgaca   5100

gccaatcaga atcagatagt aattcagaat cagatacaga aggatcagaa gaagaagatg   5160

atgatgataa agaccaagat gaatcagata gtgatactga aggagagaaa acttcaatga   5220

aactgaataa aacaacttcc tctgtcaaaa gcccttccat gagtctcaca ggtcactcaa   5280

cacctcgtaa cctccacata gcaaaagccc caggctctgc tcctgctgcc ttatgttctg   5340

aatcccagtc acctgctttt cttggtacat cttcttccac acttacttca agcccacact   5400

ctggcacttc caaaagaaga agagtaacag atgaacgtga actgcgtatt ccattggaat   5460

atggctggca gagagagaca agaataagaa actttggagg gcgccttcaa ggagaagtag   5520

catattatgc tccatgtgga aagaaactta ggcagtaccc tgaagtaata aagtatctca   5580

gcagaaatgg aataatggat atctcaaggg acaatttcag cttcagtgca aaaataagag   5640

tgggtgactt ctatgaagcc agagatggac cgcagggaat gcagtggtgt cttttgaaag   5700

aagaggatgt cattcctcgt atcagggcaa tggaaggtcg tagaggaaga ccaccaaatc   5760

cagatagaca acgagcaaga gaggaatcca ggatgagacg tcggaaaggt cgacctccaa   5820

atgttggcaa tgctgaattc ctagataacg cagatgcaaa gttgctaaga aaactgcaag   5880

ctcaagaaat agccaggcaa gcagcacaaa taaagctttt gagaaaactt caaaagcagg   5940

aacaggctcg ggttgctaaa gaagccaaaa aacaacaagc aataatggct gctgaggaga   6000

agcggaagca aaaagaacag ataaagatta tgaaacagca ggtatgtgta tacattggaa   6060

gtgactttta aaatatggga cttattttga ggatttgtta gtaatgtaca ttatttttga   6120

tttcttaaat aactatattt cacattaata tttgtgtctt atttagaaag ttgctatctt   6180

ctattaatta aaattttacc tttttaataa agtcttctac ttccaagtgt ttaaagaaat   6240

gattaccaaa cagtaaattt gtgtaagtac tttaatatcc tggtagactt tgtataagtt   6300

gatatcttga acaattttca gaatttttaa attaatgtat cagtcaatga agtatattgc   6360

tcgaatgttc aaattttaat aaaagcttgt ttttcttaaa catgtaaaat attagtagaa   6420

aattaaattc aagttataca aaataagatt tgccttcatt gcttcttaat gctttcagga   6480

ttacttaaaa gttgccactg                                               6500


<210>  8573
<211>  526
<212>  PRT
<213>  Homosapiens

<400>  8573

Met Phe Gln Gln Glu Gln Tyr Lys Gln Ala Phe Pro Ser Gln Leu Lys 
1               5                   10                  15      


Lys Gln Glu Ser Ser Lys Ser Leu Lys Lys Val Ile Ala Ala Leu Ser 
            20                  25                  30          


Asn Pro Lys Ala Thr Ser Ser Ser Pro Ala His Pro Lys Gln Thr Leu 
        35                  40                  45              


Glu Asn Asn His Pro Asn Pro Phe Leu Thr Asn Ala Leu Leu Gly Asn 
    50                  55                  60                  


His Gln Pro Asn Gly Val Ile Gln Ser Val Ile Gln Glu Ala Pro Leu 
65                  70                  75                  80  


Ala Leu Thr Thr Lys Thr Lys Met Gln Ser Lys Ile Asn Glu Asn Ile 
                85                  90                  95      


Ala Ala Ala Ser Ser Thr Pro Phe Ser Ser Pro Val Asn Leu Ser Thr 
            100                 105                 110         


Ser Gly Arg Arg Thr Pro Gly Asn Gln Thr Pro Val Met Pro Ser Ala 
        115                 120                 125             


Ser Pro Ile Leu His Ser Gln Gly Lys Glu Lys Ala Val Ser Asn Asn 
    130                 135                 140                 


Val Asn Pro Val Lys Thr Gln His His Ser His Pro Ala Lys Ser Leu 
145                 150                 155                 160 


Val Glu Gln Phe Arg Gly Thr Asp Ser Asp Ile Pro Ser Ser Lys Asp 
                165                 170                 175     


Ser Glu Asp Ser Asn Glu Asp Glu Glu Glu Asp Asp Glu Glu Glu Asp 
            180                 185                 190         


Glu Glu Asp Asp Glu Asp Asp Glu Ser Asp Asp Ser Gln Ser Glu Ser 
        195                 200                 205             


Asp Ser Asn Ser Glu Ser Asp Thr Glu Gly Ser Glu Glu Glu Asp Asp 
    210                 215                 220                 


Asp Asp Lys Asp Gln Asp Glu Ser Asp Ser Asp Thr Glu Gly Glu Lys 
225                 230                 235                 240 


Thr Ser Met Lys Leu Asn Lys Thr Thr Ser Ser Val Lys Ser Pro Ser 
                245                 250                 255     


Met Ser Leu Thr Gly His Ser Thr Pro Arg Asn Leu His Ile Ala Lys 
            260                 265                 270         


Ala Pro Gly Ser Ala Pro Ala Ala Leu Cys Ser Glu Ser Gln Ser Pro 
        275                 280                 285             


Ala Phe Leu Gly Thr Ser Ser Ser Thr Leu Thr Ser Ser Pro His Ser 
    290                 295                 300                 


Gly Thr Ser Lys Arg Arg Arg Val Thr Asp Glu Arg Glu Leu Arg Ile 
305                 310                 315                 320 


Pro Leu Glu Tyr Gly Trp Gln Arg Glu Thr Arg Ile Arg Asn Phe Gly 
                325                 330                 335     


Gly Arg Leu Gln Gly Glu Val Ala Tyr Tyr Ala Pro Cys Gly Lys Lys 
            340                 345                 350         


Leu Arg Gln Tyr Pro Glu Val Ile Lys Tyr Leu Ser Arg Asn Gly Ile 
        355                 360                 365             


Met Asp Ile Ser Arg Asp Asn Phe Ser Phe Ser Ala Lys Ile Arg Val 
    370                 375                 380                 


Gly Asp Phe Tyr Glu Ala Arg Asp Gly Pro Gln Gly Met Gln Trp Cys 
385                 390                 395                 400 


Leu Leu Lys Glu Glu Asp Val Ile Pro Arg Ile Arg Ala Met Glu Gly 
                405                 410                 415     


Arg Arg Gly Arg Pro Pro Asn Pro Asp Arg Gln Arg Ala Arg Glu Glu 
            420                 425                 430         


Ser Arg Met Arg Arg Arg Lys Gly Arg Pro Pro Asn Val Gly Asn Ala 
        435                 440                 445             


Glu Phe Leu Asp Asn Ala Asp Ala Lys Leu Leu Arg Lys Leu Gln Ala 
    450                 455                 460                 


Gln Glu Ile Ala Arg Gln Ala Ala Gln Ile Lys Leu Leu Arg Lys Leu 
465                 470                 475                 480 


Gln Lys Gln Glu Gln Ala Arg Val Ala Lys Glu Ala Lys Lys Gln Gln 
                485                 490                 495     


Ala Ile Met Ala Ala Glu Glu Lys Arg Lys Gln Lys Glu Gln Ile Lys 
            500                 505                 510         


Ile Met Lys Gln Gln Val Cys Val Tyr Ile Gly Ser Asp Phe 
        515                 520                 525     


<210>  8574
<211>  598
<212>  DNA
<213>  Homosapiens

<400>  8574
gatctcactg gaatcaagat taaagttaga ttttaggttg gctaaggaag gtgagcctgt     60

attttcaaag gatatgactc attacctggt cttttttttc cccccgagtt tccagtttaa    120

ggatctgatt gatgatagtt cctttggttt tgaacctttc tgcttttgtg ttcagtttgt    180

gcttctagaa tatagaattt aattgacagt tggatgtact ttataaaaaa gctcacttgg    240

ttacttaaga tgctatctgc ccaatatata gccagtgtct tttctattag agagtagcat    300

tcttattcca ttaacgtgcc atgtcctttt ttttcccatt tgacttttta taaattccta    360

gaggtcttca ttaaacattt atacacttaa tattccacaa ctactctcag ttctcattca    420

atgtctaaga aaatatagat gtatatagta aaatattttg ttgttttact tatttcactc    480

tcctcttgtc agtttctagc tttactttca tttaccacat accaatatga tagcctacta    540

attttagatg aacttatttg tgtttgtgaa acttgatctc ggtcttagaa aattttta      598


<210>  8575
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  8575

Met Tyr Ile Val Lys Tyr Phe Val Val Leu Leu Ile Ser Leu Ser Ser 
1               5                   10                  15      


Cys Gln Phe Leu Ala Leu Leu Ser Phe Thr Thr Tyr Gln Tyr Asp Ser 
            20                  25                  30          


Leu Leu Ile Leu Asp Glu Leu Ile Cys Val Cys Glu Thr 
        35                  40                  45  


<210>  8576
<211>  467
<212>  DNA
<213>  Homosapiens

<400>  8576
gagtaactga gagagagaga ggttgtgtta ggtagatttt aggtgtttca acaaatagag     60

cattgtaaat gcttacttgg attatgtttt catgatagct tttgataaaa gacatatgct    120

gacccttggg gtcagcaaag ctaggacaca atagtaggta ttctttcatg ccttttaact    180

gaaaaatatc acggcttgtt gttttggagt gctgtcactg ctctgaatcg aaaggataat    240

ggctacttcc tgattaaacc cactctccac aatatggagt ctggagaacg gttaccatcc    300

tcagcagcct cctctactac accaacttca tcttcgacac cttctgtggc ttcagtagtt    360

tcaaaaggtg gcctttccac tggagttgct tcacttagct ctacaatcaa cccatgtggt    420

gcagaatggt ggcgaacaac tgatgctcat actcgtacag gagcaac                  467


<210>  8577
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  8577

Met Glu Ser Gly Glu Arg Leu Pro Ser Ser Ala Ala Ser Ser Thr Thr 
1               5                   10                  15      


Pro Thr Ser Ser Ser Thr Pro Ser Val Ala Ser Val Val Ser Lys Gly 
            20                  25                  30          


Gly Leu Ser Thr Gly Val Ala Ser Leu Ser Ser Thr Ile Asn Pro Cys 
        35                  40                  45              


Gly Ala Glu Trp Trp Arg Thr Thr Asp Ala His Thr Arg Thr Gly 
    50                  55                  60              


<210>  8578
<211>  6818
<212>  DNA
<213>  Homosapiens

<400>  8578
agagagagag aggcggaaga cggagaagga gggagtcgaa ggctttcccg atcacaaatc     60

tcacctccac tacaactctc tttatacttt tcttgcagaa ataataatag aaataaggag    120

gtggtggggt ttccaaaaat cttaaccttc aaccatctgg ggaaaaggca aaaatcccat    180

ctaccgcaac tctcagttcg agagtaaagg tttcccaaca gtgatgtcac aagattgacc    240

acattgatca caatatggag tctggagaac ggttaccatc ctcagcagcc tcctctacta    300

caccaacttc atcttcgaca ccttctgtgg cttcagtagt ttcaaaaggt ggcctttcca    360

ctggagttgc ttcacttagc tctacaatca acccatgtga tccaacaaaa attatcacag    420

aagaggaact gtccttatct tttaagaata gtcatttgcc tgagtattgg tgcatcattt    480

cttgaacaaa gcttattcgg catgtttgat gttattaaat ggcagctttt cttcccaaag    540

ctaccgcggc tcccagtgac ttgttttcta ataaaaatgc cttttgaaga gaaaatggta    600

gttttacagt ggcgagtcct ggcagatacc agcttaacca agtgatcgaa gttaatgtca    660

ccagaactac atagcaacat tatgggccct agataaattg ctctgagaag ggcacattga    720

ccatcttttc taataatgca tcacctcttc taatcatgag aacacatcag acaaactcaa    780

ccagagggac attttacaga atacctctga ccagtacact tcagtgtatt aaagtcataa    840

caaacaagac tgaggaaata acacgactgt acaaaactag ggagacacaa cacctaaatg    900

taatatgaga tcctggattg gatcttggga cagagaagtg acattggtgg gaaaactaat    960

taaatctgaa taaattcttt attttaatta gttaatcaag gttaatttct tagtttggaa   1020

agttgttctt tagtcatgta agatgataac ataaggagaa gtaaggttgg gtagacagta   1080

tataggaact ctgtgtacta tttttgcaac tcttgtgagt caaaataatc tcaaaataac   1140

tacttaaaaa taaaaatagg ctgggcgcag tggctcacac ttgtaatccc agcactttgg   1200

gaggctgagg tgggcagatc acaaagtcag gagtttgaga ccgaactggc caacatggtg   1260

aaaccccatc tctactaaaa aatacaaaaa ttagctgggt gtggtgatgg gcgcctgtaa   1320

tcccaactac tcaggaggct gaggcaggag aattgtttga aactgggagg tggaggttgc   1380

agtgagcgga gatcgcacca ttacactcca gcctgggcaa cagggcaaga ctctgtctca   1440

aaaaataata ataataaaac ccaatctgaa tagacttttc tcaagaaaca tataagtggc   1500

cagcagatat atgaaaaaat gctcaacatc actaatcatt agggagatgc aaattaaaat   1560

cacaatgagc tatcatctca cacctgtcag attggctttt ctcaactaga caaaagacaa   1620

gtattggcaa ggatgtggag aaaagggaac gcttgtacac tgttaatggg gatgtaaatt   1680

agtacagcct ttatagaaaa tagtatggag gttcctcaaa aaactaaaaa tagaattacc   1740

atataatcca gccatcctgt ttgtgggatt tacccaaagg acttgtaaac agtttgtcta   1800

agagatgtct gcactcccat gttcattgca gaacgattaa caatagacac gttaaggaat   1860

cgtctttttt aagtgtcaaa atataaatgt tgagaacagc ccaagatggc caacttcaat   1920

gattgtgtgt tggataagga gaaggtatgc atagctgcta aattcatcac tcatgcaccc   1980

gcaggagaat ttaatgaagt attcagtgat attcggctac tatgtaataa tgacagtctc   2040

ctcagggaaa gggcagcacg tgcatttgcc cattataaca tggatcagtt cacacccgtg   2100

aagatggaag gatgtgaaga tcaggtcata attacagagc atgggggacc tgggtaatag   2160

cagagtttta gatccaagaa acaaaatttc ctttacattt gatcacttat agaaaaaagc   2220

aagtgacccc cagccaaaac aagtagatgg aggtctgaag tcttggagag aatcctgtga   2280

cagtgcttta agagcctatg tgaaagacca ttattccaac ggcttctgta ctgtttatgc   2340

taaaaactat cgatgggcaa cagactatta ttgcatgtat tgaaagccat gagtgtcagc   2400

ctaaaaactt ctggaatggt cgttggagat cagagtggaa gtttaccatc acaccaccta   2460

cagcccaggt ggttggagtg cttaagattc aggttcacta ttacgaagat ggcagtgttc   2520

agttggttag tcataaagat gtacaggatt cgctaactgt ttcgaatgac gcacaaactg   2580

ccaaggagtt tattaaaatc atagagaatg cagaaaatga atatcagaca gcaattagtg   2640

aaaactgtca aacaatgtca gataccacat tcaaggtctt gcgccggcag cttccggtta   2700

cccgcaccaa aattgactgg aacaagatta ctcagctaca acattagcaa agaaatgcag   2760

aatgcctaaa ggctgaatgt aggattcttc agtatgtgga aagacaagga ttcaacatgt   2820

ggtcatatga taaataagtg atttataaac aagagtgata ttttgctaga gctttcaaag   2880

ttaaccagtt ttctaacctc atggaatact gttgaaccta tagcattgtc tgattctttt   2940

gtgttctctg ctttgtaatt ttctgttatt gctatatcca agtgtaagtc tttttttttt   3000

aattctgcca catttaatgt tggagagaga gatctatcct agagacattt tactgtttaa   3060

aaaagtttcc tagccatgaa gcgctgctac tgatttagac aaggtatatg gtcattactt   3120

tctaccccta tccttccaag cacttctgat actgcagtgg tttttactga tccaccagca   3180

cctaaagagg ctgtactaca gtctatagct aagtggaagg cacattcatc cttctccctc   3240

tgactgcttt gatcatcatt tattgcatcg cagaactgta attttccaaa gtttggattg   3300

ggacttttca ggtccttttt ggagggcaaa ggaagtgtca gcttctctgg ggaacttgtt   3360

tttaaatcca aagacttgaa ccacattccc tgcacttgaa cacgtttgct ttcatccctt   3420

ctctcattgt ctccttccca tcttagtacc attgtagtta tagacatctg catttttaga   3480

agagttttag ccatttattt ttttaaacag tcaagaactg ctgacatact gtggatatag   3540

agtataaaac ttgaaaaatg cagatgttga aggaataaca ggtatcttgt gctttaatac   3600

tttatggcag gattgtacta taagcaaatg aattaaacag ctatgtaaat cataaacaaa   3660

aactgaaaat gaaccaaaat gaaaaggata acttccaggc agtatctttc tattgtaacc   3720

tgttatttaa ggaaatacta acgatttctt ctaaatagga tgtaaaactt atttcagatt   3780

actcttcctc agtcctgcct gccaagaact caagtgtaac tgtgataaaa taacctgtcc   3840

caggtatatt ggcaggtatg tgtgtaatct cagaatacac aggtgacata gatataatat   3900

aacaactggt aatggtggat tcatttacat tgcttacagt tctatgacca ggccttaagg   3960

gaaggtcagt ttaaaaaaaa aacaagtaat gtcttcctgc ctatctccac atacatgtaa   4020

aaaaaaaacg tgtttgtgct tcagttctgt ttttgctcag taatatagtc aaggaacagt   4080

ttgtttccaa gtacccattg agctgtgtat gcatttttgt ttatttcaaa taaaatatat   4140

ttgtattatt tgtcatccat actatccatc cataccacac tatcttctgt atgagatagt   4200

ctaatagaaa tatacctgtt ttgttctaaa attatatata aaggttaact ggctcaaagc   4260

atttttagaa tgcaagagtg aaatgagaat tacttggaga gaaatgtttt gtcaccagta   4320

actgtagact tctttctgtt cttaatcaaa gttcaagttt acagaatttg gacattttga   4380

gttcagaaat atttaaacat taatatactt aagaatttta atatgtgagc cagtaatttg   4440

aatattgctt tgatttacag taattttgat gatgttcttt ttgctattac actaagttat   4500

tactgatatt aattaaagtc ctcataacaa ctttatttga atataccacc atttttaatg   4560

aatagccata ctttgcaaga tgtacattag atcctgattt ttaatgttgc aaatttatgc   4620

ttaccatttt gaacaactgg agacaaaatt tgaagacatg atataacaat tttgtgtagc   4680

attgaaagat taaaagacac ttttagcaca cagaaaaacg tgaagttatg tcatggtaag   4740

caattttctt gacttttaaa aagattgagt gctttaacat acttagttct tacaattatt   4800

ttgttttatt tgctttctgg acttttcctt agtgatggga gattttgttc actggtagtt   4860

tagagtcaag gcattagttc agtacaattt cattctgata gggggaaaac cttgttgaat   4920

tattctttaa tattaataaa ggcatttgta gttaccatgc cttgttactg acacacacca   4980

gcatttgtgt actgatttta atcactttta tatgtagtga tttgatttgg ctagtagaat   5040

ttgaaaagct ttgctgaaaa atattcagct cattgtaatt tgagaacata ggcattgcag   5100

atgtgtatta atttttatta tgtaaaatgt atacagttac ctatcttaaa atagaaacta   5160

aaataatatt tacattaata atattgaaac tatgtttgaa tgttaatatc tgcaaaaaat   5220

tgtggtcttc taaaaatatt attttatggt ataattcatc agcttgcaaa tgttttctct   5280

gagcagaact caaaagtttt catcaagaca ggttttgtga gcaatacatc tgttgatatt   5340

aagtatatta atgtaagaaa cattttcttt tctaaaagtg aaacattcta ctatccaggt   5400

aattttgttt tgtacttata aggttaatag agcctatttg acttgagctg tatttcattt   5460

tgtgaaagta tctttctgct tttttattaa tactgaatat gctttgtttt aaatgtaatt   5520

ataggattga ctgagccatc atcagtctat gatcaaaatt ttcctagtga acagtagttt   5580

gaaatgttaa gatagttgaa gactaaaggc attgtcctgg caatggagcc aagggtgtaa   5640

acaaaacagc aatccctgct gtataaaaag attaaagcca caaagtgaca tcattctaaa   5700

tacctagtga gcttttacta accttgtgag tgacttttgc aattggagca aagtgacatg   5760

ttatatttta atcatttaaa gaataatttc cggttattct agccttttaa aagaagagtg   5820

aaacaaagaa ttgaaaagta ctgttttgaa gatgcctata gcaggtatta tgaagtgttg   5880

cctctgccaa ctgataacag tttgctttgt gcaatgtttt gtaaagagta aaaatggctg   5940

tttccttcat aacttttata ccctagtaat ggtctgataa aggacaaatt gccaataatc   6000

tatcatgaac aatgaaaaga ggccccaaat ataactgtct ggagattcag gaatacttct   6060

tgagcaatag gttcttgaaa tagttagtaa agaatataat tataaagggc agaaatcaaa   6120

gagcatgtta tataggcttt ggaggttctc aagtggaaga aataatgtga ccaaaaatac   6180

agcagtgaga aacaatttat taaattctta ttgtgtttca gattattgga aatcctgagc   6240

taaataagat gcagtttttg cctcaaagat ctaaaatcct ggcttataat tcatttgcat   6300

agaggtgata gtttaaacag tataagcatg tgaaatactg aaggagaaag cataagagaa   6360

ggaaagagat agctggacaa aatctttagg aatcttttac atttaggggg aaaaaagcaa   6420

aagaaaatcc aataaaggag atagtattat tgaaagatgt atagttaaga agaggatcaa   6480

gagggttcca cgacctagat cttaaggatg ataatgggtt ttgaaaagaa aggaccaggc   6540

caggcgcggt ggctcacacc tgtaatccca gcactttggg aggctgaggc gggcagatca   6600

tgaggttagg agatcaagac catcctggct aacacggtga aaccccgtct ctactaaaaa   6660

tacaaaaaat tagccgggca tggtggtggg tgcctgtagt cccagctact tgggaggctg   6720

aggcaggaga atggcgtgaa cccgggaggc ggaggttgca gtgagccgag atcgcaccac   6780

tgccctccag cctgagcaat agagcgagac tccgtctc                           6818


<210>  8579
<211>  76
<212>  PRT
<213>  Homosapiens

<400>  8579

Met Glu Ser Gly Glu Arg Leu Pro Ser Ser Ala Ala Ser Ser Thr Thr 
1               5                   10                  15      


Pro Thr Ser Ser Ser Thr Pro Ser Val Ala Ser Val Val Ser Lys Gly 
            20                  25                  30          


Gly Leu Ser Thr Gly Val Ala Ser Leu Ser Ser Thr Ile Asn Pro Cys 
        35                  40                  45              


Asp Pro Thr Lys Ile Ile Thr Glu Glu Glu Leu Ser Leu Ser Phe Lys 
    50                  55                  60                  


Asn Ser His Leu Pro Glu Tyr Trp Cys Ile Ile Ser 
65                  70                  75      


<210>  8580
<211>  666
<212>  DNA
<213>  Homosapiens

<400>  8580
gcagagagca gaccaaccca gtagtaagga agatatgatt tgctacaacc tatttacctg     60

acatgaaaac cagaatgcat cattgttaca ttttattagt gttcaggctg gatattatac    120

catggtagca tgtcgtttga catcactggt agatcttgtt ttttcttgta taataaaata    180

agagatagga catttccttt gtatcagttt tgctgtcttt cctctgcacc agtaacaaaa    240

agtaaatgtt ctaaaagtat gcaaatatga atctaaattg atgcaaactg aatgtgaaga    300

cagagtcaca tttatctact acggttagaa ataccaaact ggggaggatt aaacatcatc    360

atagattgga ctcccagctg ttgtaatggg caggatcata gaaggaagat caccaacgaa    420

aagaggaact catttcagtt aaaaagaaag gtcccttggc cagtctcagc tactgtagtt    480

gggattacag tcatgcctca ccatgcccgg ctaattttgt gtttttagta gagatggggt    540

ttctccatgt tggtcaggct ggtctcgaac tcccgacctc aggtgatccg cccaccttgg    600

cctccaaagt gctgggatta aggcatgagc caccgtggct ggcttttttt tttttttttt    660

cctgca                                                               666


<210>  8581
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  8581

Met Ser Phe Asp Ile Thr Gly Arg Ser Cys Phe Phe Leu Tyr Asn Lys 
1               5                   10                  15      


Ile Arg Asp Arg Thr Phe Pro Leu Tyr Gln Phe Cys Cys Leu Ser Ser 
            20                  25                  30          


Ala Pro Val Thr Lys Ser Lys Cys Ser Lys Ser Met Gln Ile 
        35                  40                  45      


<210>  8582
<211>  741
<212>  DNA
<213>  Homosapiens

<400>  8582
tttccactca cagtccaatt atgctcacaa ttcagccagc aaggaggaag ggggcgaaaa     60

agaggatgtg cacccattcc tttaaggata catcctgaaa gttgcacaca ctacttctgc    120

ctatatatct cttgccaaaa tttagccaga ttactatacc tagctgcaag ggagactggg    180

gaaatgatgt ttttattcta ggtagtgata taccggaaaa aaaattagaa gagggggaaa    240

accagtatta gggacaacta tcaatcatgc catacttggt tatatcttct ctgtggtagg    300

tacctgacat tttaaattta ctagctaaca ccagtatttc tgacagtatg tacactataa    360

agttatacag caattccttc tacatctcaa ttattaagta ttactattgg gagaggtgta    420

tctctacaaa atttaagtaa tattcataat aaaattacca aagagaaaaa tagaaaaaaa    480

aatttttttg aggcaaggtc ttcctctgta gcctaggctg gagtacaatg gtacaatctt    540

ggcttactgc agccttgaac tcctggactc aagcaatcct tccacctcag cttcccgagt    600

agctgggatc aggaggctga ggcaggagaa tggtgtgaac ccgggaggtg aacctggcag    660

tgggccaaga ctacaccact gcactccagc ctgggtgaca gtgagactca gactcaaaaa    720

aaaaaaaaaa aaaaaaaaag t                                              741


<210>  8583
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  8583

Met Tyr Thr Ile Lys Leu Tyr Ser Asn Ser Phe Tyr Ile Ser Ile Ile 
1               5                   10                  15      


Lys Tyr Tyr Tyr Trp Glu Arg Cys Ile Ser Thr Lys Phe Lys 
            20                  25                  30  


<210>  8584
<211>  935
<212>  DNA
<213>  Homosapiens

<400>  8584
gggagtcgaa ggctttcccg atcacaaatc tcacctccac tacaactctc tttatacttt     60

tcttgcagaa ataataatag aaataaggag gtggtggggt ttccaaaaat cttaaccttc    120

aaccatctgg ggaaaaggca aaaatcccat ctaccgcaac tctcagttcg agagtaaagg    180

tttcccaaca gtgatgtcac aagattgacc acattgatca cagtaagacc aaaatgatag    240

ttaagctttt aaggaagttt ggttttctct gagaatgaga attgacttag aaaacatata    300

taatttgaaa ttattatttc ttttgctagc cagttgaatg ttaacatttt aaatgaatca    360

tatcttatac ttctagctag ttatttaaat acttttaaaa tattacttta aaggatttaa    420

aaaacattta aaatgaaaat tacttttaat ttacaactga aattacaggc ctaaatatac    480

taaattattt cagtgtgact taaattctga acgtcatctt ttttgagttt ttatttttac    540

cagaaaatga cagaaaggtt aaggtgattc cacattagga aatatatata aaagtaaatt    600

acttgagatt gtaatgaatt attaaggaaa gattatgaaa atgtagcctt ggtaggctgg    660

gcgcggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggtggg tggatcagct    720

gaggtcagga gttcgagact agcctggcca acatggtaaa accccgactc tactaaaaat    780

acaaaaatag ctgggcatgg tggcacacac ctgtaatccc agctactcgg gaggctgaag    840

caggagaatc acttgaaccc gggaggtgga ggttgcagtg agctgagatt gtgccactgc    900

cctccaacct gggcaataga gagactccat ctcta                               935


<210>  8585
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  8585

Gly Gly Gly Gly Val Ser Lys Asn Leu Asn Leu Gln Pro Ser Gly Glu 
1               5                   10                  15      


Lys Ala Lys Ile Pro Ser Thr Ala Thr Leu Ser Ser Arg Val Lys Val 
            20                  25                  30          


Ser Gln Gln 
        35  


<210>  8586
<211>  599
<212>  DNA
<213>  Homosapiens

<400>  8586
agggaccctt tccttttaaa taggttgtac attactgact aaagctaaga tttatattca     60

gacattatgc tttctcaacc ctttttacat agtagccata caactcctta aaaagaaaat    120

cattctgtta cctttgacta tgactcaata tttaagaaat gtatttactc ataacatatt    180

tttgttgagg tagatattca tataaatcaa attaaggaac attgaattgt gtatgaaatg    240

tgaacttttt tttaaaggac tcctgatgct tagtttatct ttagagataa tatagtctta    300

attgtactac acataaacat cctgtagttt aagtaggaat tttcaggcat cagatttcta    360

gaaggaaggt aattctcaat agaaaggtca ttttaaaagt tcaaactttg atttacagtt    420

ttttctgttg accgtattaa gtatgaaatt atgggtaata aatatattta attcattttc    480

aactgcatat tgagttataa aatattggcc acatttttct cctcttaaca cttttccaca    540

aacatgcact cattaatcaa agacggtgca ctcctgctga gggcagagag gttcatcaa     599


<210>  8587
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  8587

Asn Ile Gly His Ile Phe Leu Leu Leu Thr Leu Phe His Lys His Ala 
1               5                   10                  15      


Leu Ile Asn Gln Arg Arg Cys Thr Pro Ala Glu Gly Arg Glu Val His 
            20                  25                  30          


<210>  8588
<211>  1489
<212>  DNA
<213>  Homosapiens

<400>  8588
aagaagatta aaagagggaa gcagaggagt tgggagctgg cggtcgttcc cggggaagaa     60

ctgctaaaac atgagaccaa ggcacagacc ttactgtatg agaagcaatg ctcctcaaac    120

cttctgcgtg ctgacataga ccttcccaga agcaaaactg ttggcggcga cctgagcgct    180

ggaagccgaa ggggaagagg aaggagacgc gaagccaggg cggccggcac aaaggcggcg    240

gactcgcggc ggcagcgcct gcccggccgg gagcacaacc cacggcccta ctccagcgaa    300

gtcccgcacc ggcttctagg aataaagttt acgttctcct gaggccgcac cccccacctc    360

ccacccagga cggcacatct ccgtgtcctc ctcccccaaa ctccactcgg gaccccgaga    420

accaccccag ccttccggcc accacaacaa agagccgcac cgaccggcga ggataaacag    480

cggcggaggg cgagagggcg gcggggcgag cgcctccacg cagcaactcc ggagtccccc    540

gcttgcccga gcgcagtttc tccgctgctg tttccaccgg ctttgtaaca ctgggaattt    600

acatcctcac ccgcacccct cacgcccgag gattttaaac tcacctttac tctcgaactg    660

agagttgcgg tagatgggat ttttgccttt tccccagatg gttgaaggtt aagatttttg    720

gaaaccccac cacctcctta tttctattat tatttctgca agaaaagtat aaagagagtt    780

gtagtggagg tgagatttgt gatcgggaaa gccttcgact ccctccttct ccgtcttccg    840

cctctctctc tctgattagt tcctatccag cagcagattg aagcaggaga tgattcttct    900

caaggtttgt tcagcagctt cacttctagg cgaaggcttc atgaaccaag tgacgtcaac    960

caacaaggct tctctctctc tcctctctct aacaatgaaa gttgctgtta acaagggaaa   1020

aaaagagaga gaattgttta taccatttca gttccaataa taaatgacct atcagctcct   1080

aaaggagcca agggaggggg ttgcttcttc tttccaagaa tactgtagct ttgagtttgc   1140

accgttcctt gtcccaggaa aaagttaaga aacttaaaat gttttgtttt gcttttaaag   1200

aagacaggac agaaaacggg atttaaaact tagtttttaa aaaaacaaaa gctacagagt   1260

agggagcata ggtcaaccat ctccacctaa attttttttg ttcctaaact cagaattcta   1320

caacccaact aaattaatat gccaagattt tgcggatgtt aaaactcaaa aaaagcagta   1380

tgcaagacgg tcccggggta aaattctact gcctttccac ggacaagtta aactggctgt   1440

aatgtttatg cactaagtta aaataaaatt taaataaaag acgttaaaa               1489


<210>  8589
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  8589

Met Ile Leu Leu Lys Val Cys Ser Ala Ala Ser Leu Leu Gly Glu Gly 
1               5                   10                  15      


Phe Met Asn Gln Val Thr Ser Thr Asn Lys Ala Ser Leu Ser Leu Leu 
            20                  25                  30          


Ser Leu Thr Met Lys Val Ala Val Asn Lys Gly Lys Lys Glu Arg Glu 
        35                  40                  45              


Leu Phe Ile Pro Phe Gln Phe Gln 
    50                  55      


<210>  8590
<211>  521
<212>  DNA
<213>  Homosapiens

<400>  8590
cccgcttgct tccctgcccg ccctgtgtga tctaactgca agccctttcc cttaagagtt     60

ggagcctgtt tgtccaacct tgtgatcatt tccttgtggt ctcttagaca tcttctcaag    120

attatgctaa gagaaatgac tgcacccttt tcctgagcta tggcagtcag acctggcagt    180

ggtaactact ctacagaact cccaaacctg gcaaggatgg tgcagatttt ggcagattat    240

ggctttgtcc ccacccagca ctgatgatat tataaaacct atactacaag aaatgataat    300

ggaagttctt caactgagca agaaatgata ttaacagaaa acttggatct tcagaagcaa    360

atgaagaaca tcagaaatgt agcaacagct gctgagaaga gatgactaaa agctgaaaag    420

tgaagaatta acactgattt cttggcagaa gcagaagctt caggactcct gaattgaggg    480

aatgatctaa attccaagga ttatctctca gtgagaacaa g                        521


<210>  8591
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  8591

Met Ala Val Arg Pro Gly Ser Gly Asn Tyr Ser Thr Glu Leu Pro Asn 
1               5                   10                  15      


Leu Ala Arg Met Val Gln Ile Leu Ala Asp Tyr Gly Phe Val Pro Thr 
            20                  25                  30          


Gln His 
        


<210>  8592
<211>  456
<212>  DNA
<213>  Homosapiens

<400>  8592
ggacttcctg gcttctcgcg agagtggcgg cgcggcgggg accgagagct gcgggcgggc     60

tggaggtacc ccaccgcggg gtggtgctct gactgcggga accgttgaag agctgccccc    120

ggggagtcag cgaggcgcca ctggtctctt agacatcttc tcaagattat gctaagagaa    180

atgactgcac ccttttcctg agctatggca gtcagacctg gcagtggtaa ctactctaca    240

gaactcccaa acctggcaag gatggtgcag attttggcag attatggctt tgtccccacc    300

cagcactgat gatattataa aacctatact acaagaaatg ataatggaag ttcttcaact    360

gagcaagaaa tgatattaac agaaaacttg gatcttcaga agcaaatgaa gaacatcaga    420

aatgacggag tctcttgctg tgttgcccag actgga                              456


<210>  8593
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  8593

Met Ala Val Arg Pro Gly Ser Gly Asn Tyr Ser Thr Glu Leu Pro Asn 
1               5                   10                  15      


Leu Ala Arg Met Val Gln Ile Leu Ala Asp Tyr Gly Phe Val Pro Thr 
            20                  25                  30          


Gln His 
        


<210>  8594
<211>  532
<212>  DNA
<213>  Homosapiens

<400>  8594
atggatctta cttgtaacaa aatgtgttct atggtcaaaa aatggcagac aatgatcgaa     60

gctcctgttg atgtcaagac tactgatagt tacttgcttc atctgttctg tgttgacttt    120

actaaaatac acaacaatca gatatggatg acctcttatg ctcagtacca gcaattctgc    180

caaatctgga agaagatgat ggaaatcatg acccaagagg tgcagacaaa tgacttgaaa    240

gaagtggtca ataaattgat tccagacaac attggaaaag acatagaaaa gtcttgccaa    300

tctatttatc gtctccatga tttctttgtt agaaaataaa aatgctgaag aagcccaagt    360

ttgaattggg aaaactcatg gagcttcatg gtgaaggtag tagtactgga aaagccactg    420

gggatgagac aggtgttaaa gttgaatgag ttgatggata tgaaccacca gtccaagaat    480

ctgtttaaag ttcagactta taatagtggc aaataaaaag tcctatttgt ga            532


<210>  8595
<211>  112
<212>  PRT
<213>  Homosapiens

<400>  8595

Met Asp Leu Thr Cys Asn Lys Met Cys Ser Met Val Lys Lys Trp Gln 
1               5                   10                  15      


Thr Met Ile Glu Ala Pro Val Asp Val Lys Thr Thr Asp Ser Tyr Leu 
            20                  25                  30          


Leu His Leu Phe Cys Val Asp Phe Thr Lys Ile His Asn Asn Gln Ile 
        35                  40                  45              


Trp Met Thr Ser Tyr Ala Gln Tyr Gln Gln Phe Cys Gln Ile Trp Lys 
    50                  55                  60                  


Lys Met Met Glu Ile Met Thr Gln Glu Val Gln Thr Asn Asp Leu Lys 
65                  70                  75                  80  


Glu Val Val Asn Lys Leu Ile Pro Asp Asn Ile Gly Lys Asp Ile Glu 
                85                  90                  95      


Lys Ser Cys Gln Ser Ile Tyr Arg Leu His Asp Phe Phe Val Arg Lys 
            100                 105                 110         


<210>  8596
<211>  2522
<212>  DNA
<213>  Homosapiens

<400>  8596
gagtggcggc gcggcgggga ccgagagctg cgggcgggct ggaggtaccc caccgcgggg     60

tggtgctctg actgcgggaa ccgttgaaga gctgcccccg gggagtcagc gaggcgccac    120

tggtctctta gacatcttct caagattatg ctaagagaaa tgactgcacc cttttcctga    180

gctatggcag tcagacctgg cagtggtaac tactctacag aactcccaaa cctggcaagg    240

atggtgcaga ttttggcaga ttatggcttt gtccccaccc agcactgatg atattataaa    300

atatgacacc ttcaagtata agcaaccaaa gaaaactaga taaattggac ctcataaagt    360

aaaacaaaca aaaacctttt gcttcaaagg ataccactaa gcaagcgaaa agacaacaca    420

tagaatgtga gaaaaaggtt gtaaatccta tatatgacaa ggcacctgta tccagaataa    480

agaacctctt aaaactcaac aataaaaaca caaataatct aattgtaaaa tagcttacaa    540

tcattattgt aaaattggca aaggatttaa atagatattt ttctaaagaa gatataaaaa    600

tagtcaataa atgcataaaa aatagacaat aaatatatgc tcagcctcag cagtcattag    660

ggaaatgtaa atcaaaacca caagggaagt atttattcac acacactaat atggctacaa    720

taaaaaacct agacagtaaa aaatgttgat gaggatgtag aaagttggta cctgcatata    780

ttgctgttag gaatgtaaaa tggtacagct gtttgggaaa gcagtttagc agtcctcaaa    840

agtttaatta tagttaccat atgactcagc aatatcgtta ctaagtatat actcaggagg    900

actgaaaaca catgtcacac aaaaccctat acacaaatgt tcatgtcata gtagtcaaaa    960

tgtggaaaca actgaaatgt gcaacaatgg atgaatggat aaacaaaatg tggtatatcc   1020

atccagtgga atattattta gccttaaaaa ggaatgaagt tctgctgcat gctgcaacat   1080

ggatgaacct tgaaaacatt atcattagag atggaaacca aacataaaag gtcacattgt   1140

attattccat ttatatcact gtccagaata ggcaaatcca tagagataca aaacagataa   1200

gtggttccca ggtactggga aaagcaagag gtaggagtga ctgctaatga gtatagggtt   1260

tctttttgag gtgatgaaaa tgttctgcaa ctagatagtg gtgtttgttt tatgaacttg   1320

tgaatatact aaaagccact ggattatata ttttatgtat ttgtttgtta ggactgtcat   1380

aacaaataat actacaggct ggtggcaaca gaaatgtatt ttctcaccgt gtggagtcta   1440

gaagtccaca gtcaaaatgt ctcaagggtt gttttcattc tcaggcctct tttttggctt   1500

gtagatggct aacttccctg tggcctcaca tggtcacccc ttggtctgtg tgttgtctgt   1560

gtcctaacct cctcttataa ggacaccagt catattgaat tagggcccac atatatgaca   1620

ttttacctta cttgtctctt taaaggtccc atctccaaat tcaatcacat tctaaggtac   1680

tagaggtgtt aggacttcca cacgtgaatt tagttgggga gggagacaca acacttgaaa   1740

acctaggggt gaattttatg atatgtaaat tatacctcaa ttttgaaaaa tataagaacc   1800

tacttttctt tccaaataag tttgaaaact taaatgaaaa aagtaatttt cagctgggca   1860

cagtagtaca cacctgtcag tcccagttac tcaagaggct gaggaaggag gattgcttga   1920

gaccaggagt ttaaggctgc atctgtgaat agtcacggta ctccagcctg ggcaacataa   1980

tgagacccca tctcttaaaa aaaaaaaaaa gatggtcagg tgcaatgact cacactttga   2040

gaggtcaagg tgtgaggatc ccttgaatct aggagtttaa gaccagcctg gacaacatag   2100

tgagaccctg actctacaaa aaataaaaac ttagccaggt atggtggcac atgcctatgg   2160

tcgcagctac ttgggagact cagatgggag gatcgcttga gccttggagg tggagactgc   2220

agtgagccat gatctcacca ttgcgcttag cctgggaggc agggtgagac cctgtctcaa   2280

aaaaaaaaaa aaaaaagttt atttttaagg caaatatatt tcatcaaaat tggccacatt   2340

tgagaaagtt taatttctgt agaagaaata gaaaagaata tcaaggatcc acctcataaa   2400

aaagcaccag tcccagatgg ttttatagag ataatctgtg aaacactcaa agatattctc   2460

aatgctccgt aaactggtgc tgagcattga acatggataa taccaattcc taaagacagc   2520

ac                                                                  2522


<210>  8597
<211>  71
<212>  PRT
<213>  Homosapiens

<400>  8597

Met Ser His Lys Thr Leu Tyr Thr Asn Val His Val Ile Val Val Lys 
1               5                   10                  15      


Met Trp Lys Gln Leu Lys Cys Ala Thr Met Asp Glu Trp Ile Asn Lys 
            20                  25                  30          


Met Trp Tyr Ile His Pro Val Glu Tyr Tyr Leu Ala Leu Lys Arg Asn 
        35                  40                  45              


Glu Val Leu Leu His Ala Ala Thr Trp Met Asn Leu Glu Asn Ile Ile 
    50                  55                  60                  


Ile Arg Asp Gly Asn Gln Thr 
65                  70      


<210>  8598
<211>  446
<212>  DNA
<213>  Homosapiens

<400>  8598
ggttggcttt tttttttttt ttttttcttt ttctggctct tggtctctta gacatcttct     60

caagattatg ctaagagaaa tgactgcacc cttttcctga gctatggcag tcagacctgg    120

cagtggtaac tactctacag aactcccaaa cctggcaagg atggtgcaga ttttggcaga    180

ttatggcttt gtccccaccc agcactgatg atattataaa atatgacacc ttcaagtata    240

agcaaccaaa gaaaactaga taaattggac ctcataaagt aaaacaaaca aaaacctttt    300

gcttcaaagg ataccactaa gcaagcgaaa agacaacaca tagaatgtga gaaaaaggtt    360

gtaaatccta tatatgacaa ggcacctgta tccagaataa agaacctctt aaaactcaac    420

aataaaaaca caaataatct aattgt                                         446


<210>  8599
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  8599

Met Ala Val Arg Pro Gly Ser Gly Asn Tyr Ser Thr Glu Leu Pro Asn 
1               5                   10                  15      


Leu Ala Arg Met Val Gln Ile Leu Ala Asp Tyr Gly Phe Val Pro Thr 
            20                  25                  30          


Gln His 
        


<210>  8600
<211>  2696
<212>  DNA
<213>  Homosapiens

<400>  8600
gaagtggggg gaggaggagc agggaggggc acttaacggt ggtggctggt tctgcgccgg     60

atccgggaga ggggcgggcg ccattgtgct tcgctgccga ctgcatttcc tcagtcacgg    120

gcctagaact ccaaggagaa aggcggcgaa aaatctttaa gaatggagtc taaaccttca    180

aggattccaa gaagaatttc tgttcaacct tccagctcct taagtgctag gatgatgtct    240

ggaagcagag gaagtagttt aaatgatacc tatcactcaa gagactcttc atttagattg    300

gattctgaat atcagtctac atcagcatca gcatctgcgt caccatttca atctgcatgg    360

tatagtgaat ctgagataac tcagggagca cgctcaagat cgcagaacca gcaacgggat    420

catgattcaa aaagacctaa actttcctgt acaaactgta ctacctcagc tgggagaaat    480

gttggaaatg gtttaaacac attatcagat tcatcttgga ggcatagtca agttcctaga    540

tcttcatcaa tggtacttgg atcatttgga acagacttaa tgagagagag gagagatttg    600

gagagaagaa cagattcctc tattagtaat cttatggatt atagtcaccg aagtggtgat    660

ttcacaactt catcatatgt tcaagacaga gttccttcat attcacaagg agcaagacca    720

aaagaaaact caatgagcac tttacagttg aatacatcat ccacaaacca ccaattgcct    780

tctgaacatc agaccatact aagttctagg gactccagaa attctttaag atcaaatttt    840

tcttcaagag aatcagaatc ttcccgaagc aatacgcagc ctggattttc ttacagttca    900

agtagagatg aagccccaat cataagcaat tcagaaaggg ttgtttcatc tcaaagacca    960

tttcaagaat cttctgacaa tgaaggtagg cggacaacga ggagattgct gtcacgcata   1020

gcttctagca tgtcatctac ttttttttca cgaagatcta gtcaggattc cttgaataca   1080

agatcattga attctgaaaa ttcttacgtt tctccaagaa tcttgacagc ttcacagtcc   1140

cgtagtaatg taccatcagc ttctgaagtt cccgataata gggcatctga agcttctcag   1200

ggatttcgat ttcttaggcg aagatggggt ttgtcatctc ttagccacaa tcatagctct   1260

gagtcagatt cagaaaattt taaccaagaa tctgaaggta gaaatacagg accatggtta   1320

tcttcctcac ttagaaatag atgcacacct ttgttctcta gaaggaggcg agagggaaga   1380

gatgaatctt caaggatacc tacctctgat acatcatcta gatctcatat ttttagaaga   1440

gaatcaaatg aagtggttca ccttgaagca cagaatgatc ctcttggagc tgctgccaac   1500

agaccacaag catctgcagc atcaagcagt gccacaacag gtggctctac atcagattcg   1560

gctcaaggtg gaagaaatac aggaatatca gggattcttc ctggttcctt attccggttt   1620

gcagtccctc cagcacttgg gagtaatttg accgacaatg tcatgatcac agtagatatt   1680

attccttcag gttggaattc agctgatggt aaaagtgata aaactaaaag tgcgccttca   1740

agagatccag aaagattgca gaaaataaaa gagagcctcc ttttagagga ctcagaagaa   1800

gaagaaggtg acttatgtag aatttgtcaa atggcagctg catcatcatc taatttgctg   1860

atagagccat gcaagtgcac aggaagtttg cagtatgtcc accaagactg tatgaaaaag   1920

tggttacagg ccaaaattaa ctctggttct tcattagaag ctgtaaccac ctgtgaacta   1980

tgtaaagaga agttggagct taacctggag gattttgata ttcatgaact acatagagct   2040

catgcaaatg aacaagctga gtatgagttt atcagctctg gtctctacct agtggtgtta   2100

ttgcacttgt gcgaacaaag cttttctgat atgatgggaa atacaaatga accaagcaca   2160

cgtgtccgat ttattaacct tgcaagaact cttcaggcac atatggaaga tctcgaaact   2220

tcagaggatg attccgaaga agacggagac cataacagga catttgatat tgcctaactt   2280

catataagac agatggatga tctgtgaaca taagtgttta ttaaaaatgg caattaaata   2340

taaattactt ttgtggggga atgcctaata aatacattga ctatatataa aatgaatata   2400

tacatacaca tgtatgcctg tatatatata ttcattctcc agtgttgctg aattaaaatt   2460

ctgctggact ttttaacata gcaaatccga tgtttataaa ctggtaatca aaaaggtttt   2520

ttcttttagg tgagtgggaa agtattaccc ttgttttaaa tatctaagca atgcctatca   2580

accctttttt gtgttatgat tactgtagtc atatttatga aaaaaggttt gtgttttact   2640

cttgctagtg agaaaagtgg gacaaaatat acttttgaaa taaaatgcta tatggc       2696


<210>  8601
<211>  704
<212>  PRT
<213>  Homosapiens

<400>  8601

Met Glu Ser Lys Pro Ser Arg Ile Pro Arg Arg Ile Ser Val Gln Pro 
1               5                   10                  15      


Ser Ser Ser Leu Ser Ala Arg Met Met Ser Gly Ser Arg Gly Ser Ser 
            20                  25                  30          


Leu Asn Asp Thr Tyr His Ser Arg Asp Ser Ser Phe Arg Leu Asp Ser 
        35                  40                  45              


Glu Tyr Gln Ser Thr Ser Ala Ser Ala Ser Ala Ser Pro Phe Gln Ser 
    50                  55                  60                  


Ala Trp Tyr Ser Glu Ser Glu Ile Thr Gln Gly Ala Arg Ser Arg Ser 
65                  70                  75                  80  


Gln Asn Gln Gln Arg Asp His Asp Ser Lys Arg Pro Lys Leu Ser Cys 
                85                  90                  95      


Thr Asn Cys Thr Thr Ser Ala Gly Arg Asn Val Gly Asn Gly Leu Asn 
            100                 105                 110         


Thr Leu Ser Asp Ser Ser Trp Arg His Ser Gln Val Pro Arg Ser Ser 
        115                 120                 125             


Ser Met Val Leu Gly Ser Phe Gly Thr Asp Leu Met Arg Glu Arg Arg 
    130                 135                 140                 


Asp Leu Glu Arg Arg Thr Asp Ser Ser Ile Ser Asn Leu Met Asp Tyr 
145                 150                 155                 160 


Ser His Arg Ser Gly Asp Phe Thr Thr Ser Ser Tyr Val Gln Asp Arg 
                165                 170                 175     


Val Pro Ser Tyr Ser Gln Gly Ala Arg Pro Lys Glu Asn Ser Met Ser 
            180                 185                 190         


Thr Leu Gln Leu Asn Thr Ser Ser Thr Asn His Gln Leu Pro Ser Glu 
        195                 200                 205             


His Gln Thr Ile Leu Ser Ser Arg Asp Ser Arg Asn Ser Leu Arg Ser 
    210                 215                 220                 


Asn Phe Ser Ser Arg Glu Ser Glu Ser Ser Arg Ser Asn Thr Gln Pro 
225                 230                 235                 240 


Gly Phe Ser Tyr Ser Ser Ser Arg Asp Glu Ala Pro Ile Ile Ser Asn 
                245                 250                 255     


Ser Glu Arg Val Val Ser Ser Gln Arg Pro Phe Gln Glu Ser Ser Asp 
            260                 265                 270         


Asn Glu Gly Arg Arg Thr Thr Arg Arg Leu Leu Ser Arg Ile Ala Ser 
        275                 280                 285             


Ser Met Ser Ser Thr Phe Phe Ser Arg Arg Ser Ser Gln Asp Ser Leu 
    290                 295                 300                 


Asn Thr Arg Ser Leu Asn Ser Glu Asn Ser Tyr Val Ser Pro Arg Ile 
305                 310                 315                 320 


Leu Thr Ala Ser Gln Ser Arg Ser Asn Val Pro Ser Ala Ser Glu Val 
                325                 330                 335     


Pro Asp Asn Arg Ala Ser Glu Ala Ser Gln Gly Phe Arg Phe Leu Arg 
            340                 345                 350         


Arg Arg Trp Gly Leu Ser Ser Leu Ser His Asn His Ser Ser Glu Ser 
        355                 360                 365             


Asp Ser Glu Asn Phe Asn Gln Glu Ser Glu Gly Arg Asn Thr Gly Pro 
    370                 375                 380                 


Trp Leu Ser Ser Ser Leu Arg Asn Arg Cys Thr Pro Leu Phe Ser Arg 
385                 390                 395                 400 


Arg Arg Arg Glu Gly Arg Asp Glu Ser Ser Arg Ile Pro Thr Ser Asp 
                405                 410                 415     


Thr Ser Ser Arg Ser His Ile Phe Arg Arg Glu Ser Asn Glu Val Val 
            420                 425                 430         


His Leu Glu Ala Gln Asn Asp Pro Leu Gly Ala Ala Ala Asn Arg Pro 
        435                 440                 445             


Gln Ala Ser Ala Ala Ser Ser Ser Ala Thr Thr Gly Gly Ser Thr Ser 
    450                 455                 460                 


Asp Ser Ala Gln Gly Gly Arg Asn Thr Gly Ile Ser Gly Ile Leu Pro 
465                 470                 475                 480 


Gly Ser Leu Phe Arg Phe Ala Val Pro Pro Ala Leu Gly Ser Asn Leu 
                485                 490                 495     


Thr Asp Asn Val Met Ile Thr Val Asp Ile Ile Pro Ser Gly Trp Asn 
            500                 505                 510         


Ser Ala Asp Gly Lys Ser Asp Lys Thr Lys Ser Ala Pro Ser Arg Asp 
        515                 520                 525             


Pro Glu Arg Leu Gln Lys Ile Lys Glu Ser Leu Leu Leu Glu Asp Ser 
    530                 535                 540                 


Glu Glu Glu Glu Gly Asp Leu Cys Arg Ile Cys Gln Met Ala Ala Ala 
545                 550                 555                 560 


Ser Ser Ser Asn Leu Leu Ile Glu Pro Cys Lys Cys Thr Gly Ser Leu 
                565                 570                 575     


Gln Tyr Val His Gln Asp Cys Met Lys Lys Trp Leu Gln Ala Lys Ile 
            580                 585                 590         


Asn Ser Gly Ser Ser Leu Glu Ala Val Thr Thr Cys Glu Leu Cys Lys 
        595                 600                 605             


Glu Lys Leu Glu Leu Asn Leu Glu Asp Phe Asp Ile His Glu Leu His 
    610                 615                 620                 


Arg Ala His Ala Asn Glu Gln Ala Glu Tyr Glu Phe Ile Ser Ser Gly 
625                 630                 635                 640 


Leu Tyr Leu Val Val Leu Leu His Leu Cys Glu Gln Ser Phe Ser Asp 
                645                 650                 655     


Met Met Gly Asn Thr Asn Glu Pro Ser Thr Arg Val Arg Phe Ile Asn 
            660                 665                 670         


Leu Ala Arg Thr Leu Gln Ala His Met Glu Asp Leu Glu Thr Ser Glu 
        675                 680                 685             


Asp Asp Ser Glu Glu Asp Gly Asp His Asn Arg Thr Phe Asp Ile Ala 
    690                 695                 700                 


<210>  8602
<211>  3518
<212>  DNA
<213>  Homosapiens

<400>  8602
gaagtggggg gaggaggagc agggaggggc acttaacggt ggtggctggt tctgcgccgg     60

atccgggaga ggggcgggcg ccattgtgct tcgctgccga ctgcatttcc tcagtcacgg    120

gcctagaact ccaaggagaa aggcggcgaa aaatctttaa gaatggagtc taaaccttca    180

aggattccaa gaagaatttc tgttcaacct tccagctcct taagtgctag gatgatgtct    240

ggaagcagag gaagtagttt aaatgatacc tatcactcaa gagactcttc atttagattg    300

gattctgaat atcagtctac atcagcatca gcatctgcgt caccatttca atctgcatgg    360

tatagtgaat ctgagataac tcagggagca cgctcaagat cgcagaacca gcaacgggat    420

catgattcaa aaagacctaa actttcctgt acaaactgta ctacctcagc tgggagaaat    480

gttggaaatg gtttaaacac attatcagat tcatcttgga ggcatagtca agttcctaga    540

tcttcatcaa tggtacttgg atcatttgga acagacttaa tgagagagag gagagatttg    600

gagagaagaa cagattcctc tattagtaat cttatggatt atagtcaccg aagtggtgat    660

ttcacaactt catcatatgt tcaagacaga gttccttcat attcacaagg agcaagacca    720

aaagaaaact caatgagcac tttacagttg aatacatcat ccacaaacca ccaattgcct    780

tctgaacatc agaccatact aagttctagg gactccagaa attctttaag atcaaatttt    840

tcttcaagag aatcagaatc ttcccgaagc aatacgcagc ctggattttc ttacagttca    900

agtagagatg aagccccaat cataagcaat tcagaaaggg ttgtttcatc tcaaagacca    960

tttcaagaat cttctgacaa tgaaggtagg cggacaacga ggagattgct gtcacgcata   1020

gcttctagca tgtcatctac ttttttttca cgaagatcta gtcaggattc cttgaataca   1080

agatcattga attctgaaaa ttcttacgtt tctccaagaa tcttgacagc ttcacagtcc   1140

cgtagtaatg taccatcagc ttctgaagtt cccgataata gggcatctga agcttctcag   1200

ggatttcgat ttcttaggcg aagatggggt ttgtcatctc ttagccacaa tcatagctct   1260

gagtcagatt cagaaaattt taaccaagaa tctgaaggta gaaatacagg accatggtta   1320

tcttcctcac ttagaaatag atgcacacct ttgttctcta gaaggaggcg agagggaaga   1380

gatgaatctt caaggatacc tacctctgat acatcatcta gatctcatat ttttagaaga   1440

gaatcaaatg aagtggttca ccttgaagca cagaatgatc ctcttggagc tgctgccaac   1500

agaccacaag catctgcagc atcaagcagt gccacaacag gtggctctac atcagattcg   1560

gctcaaggtg gaagaaatac aggaatatca gggattcttc ctggttcctt attccggttt   1620

gcagtccctc cagcacttgg gagtaatttg accgacaatg tcatgatcac agtagatatt   1680

attccttcag gttggaattc agctgatggt aaaagtgata aaactaaaag tgcgccttca   1740

agagatccag aaagattgca gaaaataaaa gagagcctcc ttttagagga ctcagaagaa   1800

gaagaaggtg acttatgtag aatttgtcaa atggcagctg catcatcatc taatttgctg   1860

atagagccat gcaagtgcac aggaagtttg cagtatgtcc accaagactg tatgaaaaag   1920

tggttacagg ccaaaattaa ctctggttct tcattagaag ctgtaaccac ctgtgaacta   1980

tgtaaagaga agttggagct taacctggag gattttgata ttcatgaact acatagagct   2040

catgcaaatg aacaagctga gtatgagttt atcagctctg gtctctacct agtggtgtta   2100

ttgcacttgt gcgaacaaag cttttctgat atgatgggaa atacaaatga accaagcaca   2160

cgtgtccgat ttattaacct tgcaagaact cttcaggcac atatggaaga tctcgaaact   2220

tcagaggatg attccgaaga agacggagac cataacagga catttgatat tgcctaactt   2280

catataagac agatggatga tctgtgaaca taagtgttta ttaaaaatgg caattaaata   2340

taaattactt ttgtggggga atgcctaata aatacattga ctatatataa aatgaatata   2400

tacatacaca tgtatgcctg tatatatata ttcattctcc agtgttgctg aattaaaatt   2460

ctgctggact ttttaacata gcaaatccga tgtttataaa ctggtaatca aaaaggtttt   2520

ttcttttagg tgagtgggaa agtattaccc ttgttttaaa tatctaagca atgcctatca   2580

accctttttt gtgttatgat tactgtagtc atatttatga aaaaaggttt gtgttttact   2640

cttgctagtg agaaaagtgg gacaaaatat acttttgaaa taaaatgcta tatggcacct   2700

aattattttt tcttttaaaa tgccttaagt tgcagtctca ttttgataat catttgcttc   2760

cagtgtttaa aaattaaaaa aagaatgggg agaaggttat gagaagagca ttattaagtt   2820

tccaaattta atttgaattc caaattcacc tagcaataaa atctaatttt taaaaagtat   2880

ataaatataa aatgtataaa tgatggatag atttttgtat tgatttgcaa aatgcagatt   2940

atatttgata ggctatagta tgtagatatt ccttttagga atattacagc tgtaaattat   3000

atgagacttg ccagtcaaat gctatttggt ttaaaaaaat tattgcaatc tcaagttaat   3060

ggaatatttt taaatcccac attcagagtt taaaacactg gttttcaatg tgttttttag   3120

tgttgtcact tgtttataga taaatatata aataacctgt ttggatcctg gtccttttta   3180

actgttcctt ggtaattctg agcatttatt tgatgactta atatttttca ctacctttgg   3240

agaacagatg aacattattc accatgaatg gatctatact gtgtggtcat gagttgtgta   3300

tacttccata acactgtatt tttcttctgt cagtaccctt aggatacact ttaaaacacc   3360

ttaaggtctg atgttatggc aacaaactac tttttcaaac ctaaatagga accatgtaat   3420

ttctcaaaag tgattgaaca gtttgcccac acttagtttg ttggtcttat gtaaaacatt   3480

ggctcaaaat aaagtacaca ctgatttatt ttactgtt                           3518


<210>  8603
<211>  704
<212>  PRT
<213>  Homosapiens

<400>  8603

Met Glu Ser Lys Pro Ser Arg Ile Pro Arg Arg Ile Ser Val Gln Pro 
1               5                   10                  15      


Ser Ser Ser Leu Ser Ala Arg Met Met Ser Gly Ser Arg Gly Ser Ser 
            20                  25                  30          


Leu Asn Asp Thr Tyr His Ser Arg Asp Ser Ser Phe Arg Leu Asp Ser 
        35                  40                  45              


Glu Tyr Gln Ser Thr Ser Ala Ser Ala Ser Ala Ser Pro Phe Gln Ser 
    50                  55                  60                  


Ala Trp Tyr Ser Glu Ser Glu Ile Thr Gln Gly Ala Arg Ser Arg Ser 
65                  70                  75                  80  


Gln Asn Gln Gln Arg Asp His Asp Ser Lys Arg Pro Lys Leu Ser Cys 
                85                  90                  95      


Thr Asn Cys Thr Thr Ser Ala Gly Arg Asn Val Gly Asn Gly Leu Asn 
            100                 105                 110         


Thr Leu Ser Asp Ser Ser Trp Arg His Ser Gln Val Pro Arg Ser Ser 
        115                 120                 125             


Ser Met Val Leu Gly Ser Phe Gly Thr Asp Leu Met Arg Glu Arg Arg 
    130                 135                 140                 


Asp Leu Glu Arg Arg Thr Asp Ser Ser Ile Ser Asn Leu Met Asp Tyr 
145                 150                 155                 160 


Ser His Arg Ser Gly Asp Phe Thr Thr Ser Ser Tyr Val Gln Asp Arg 
                165                 170                 175     


Val Pro Ser Tyr Ser Gln Gly Ala Arg Pro Lys Glu Asn Ser Met Ser 
            180                 185                 190         


Thr Leu Gln Leu Asn Thr Ser Ser Thr Asn His Gln Leu Pro Ser Glu 
        195                 200                 205             


His Gln Thr Ile Leu Ser Ser Arg Asp Ser Arg Asn Ser Leu Arg Ser 
    210                 215                 220                 


Asn Phe Ser Ser Arg Glu Ser Glu Ser Ser Arg Ser Asn Thr Gln Pro 
225                 230                 235                 240 


Gly Phe Ser Tyr Ser Ser Ser Arg Asp Glu Ala Pro Ile Ile Ser Asn 
                245                 250                 255     


Ser Glu Arg Val Val Ser Ser Gln Arg Pro Phe Gln Glu Ser Ser Asp 
            260                 265                 270         


Asn Glu Gly Arg Arg Thr Thr Arg Arg Leu Leu Ser Arg Ile Ala Ser 
        275                 280                 285             


Ser Met Ser Ser Thr Phe Phe Ser Arg Arg Ser Ser Gln Asp Ser Leu 
    290                 295                 300                 


Asn Thr Arg Ser Leu Asn Ser Glu Asn Ser Tyr Val Ser Pro Arg Ile 
305                 310                 315                 320 


Leu Thr Ala Ser Gln Ser Arg Ser Asn Val Pro Ser Ala Ser Glu Val 
                325                 330                 335     


Pro Asp Asn Arg Ala Ser Glu Ala Ser Gln Gly Phe Arg Phe Leu Arg 
            340                 345                 350         


Arg Arg Trp Gly Leu Ser Ser Leu Ser His Asn His Ser Ser Glu Ser 
        355                 360                 365             


Asp Ser Glu Asn Phe Asn Gln Glu Ser Glu Gly Arg Asn Thr Gly Pro 
    370                 375                 380                 


Trp Leu Ser Ser Ser Leu Arg Asn Arg Cys Thr Pro Leu Phe Ser Arg 
385                 390                 395                 400 


Arg Arg Arg Glu Gly Arg Asp Glu Ser Ser Arg Ile Pro Thr Ser Asp 
                405                 410                 415     


Thr Ser Ser Arg Ser His Ile Phe Arg Arg Glu Ser Asn Glu Val Val 
            420                 425                 430         


His Leu Glu Ala Gln Asn Asp Pro Leu Gly Ala Ala Ala Asn Arg Pro 
        435                 440                 445             


Gln Ala Ser Ala Ala Ser Ser Ser Ala Thr Thr Gly Gly Ser Thr Ser 
    450                 455                 460                 


Asp Ser Ala Gln Gly Gly Arg Asn Thr Gly Ile Ser Gly Ile Leu Pro 
465                 470                 475                 480 


Gly Ser Leu Phe Arg Phe Ala Val Pro Pro Ala Leu Gly Ser Asn Leu 
                485                 490                 495     


Thr Asp Asn Val Met Ile Thr Val Asp Ile Ile Pro Ser Gly Trp Asn 
            500                 505                 510         


Ser Ala Asp Gly Lys Ser Asp Lys Thr Lys Ser Ala Pro Ser Arg Asp 
        515                 520                 525             


Pro Glu Arg Leu Gln Lys Ile Lys Glu Ser Leu Leu Leu Glu Asp Ser 
    530                 535                 540                 


Glu Glu Glu Glu Gly Asp Leu Cys Arg Ile Cys Gln Met Ala Ala Ala 
545                 550                 555                 560 


Ser Ser Ser Asn Leu Leu Ile Glu Pro Cys Lys Cys Thr Gly Ser Leu 
                565                 570                 575     


Gln Tyr Val His Gln Asp Cys Met Lys Lys Trp Leu Gln Ala Lys Ile 
            580                 585                 590         


Asn Ser Gly Ser Ser Leu Glu Ala Val Thr Thr Cys Glu Leu Cys Lys 
        595                 600                 605             


Glu Lys Leu Glu Leu Asn Leu Glu Asp Phe Asp Ile His Glu Leu His 
    610                 615                 620                 


Arg Ala His Ala Asn Glu Gln Ala Glu Tyr Glu Phe Ile Ser Ser Gly 
625                 630                 635                 640 


Leu Tyr Leu Val Val Leu Leu His Leu Cys Glu Gln Ser Phe Ser Asp 
                645                 650                 655     


Met Met Gly Asn Thr Asn Glu Pro Ser Thr Arg Val Arg Phe Ile Asn 
            660                 665                 670         


Leu Ala Arg Thr Leu Gln Ala His Met Glu Asp Leu Glu Thr Ser Glu 
        675                 680                 685             


Asp Asp Ser Glu Glu Asp Gly Asp His Asn Arg Thr Phe Asp Ile Ala 
    690                 695                 700                 


<210>  8604
<211>  6700
<212>  DNA
<213>  Homosapiens

<400>  8604
gaagtggggg gaggaggagc agggaggggc acttaacggt ggtggctggt tctgcgccgg     60

atccgggaga ggggcgggcg ccattgtgct tcgctgccga ctgcatttcc tcagtcacgg    120

gcctagaact ccaaggagaa aggcggcgaa aaatctttaa gaatggagtc taaaccttca    180

aggattccaa gaagaatttc tgttcaacct tccagctcct taagtgctag gatgatgtct    240

ggaagcagag gaagtagttt aaatgatacc tatcactcaa gagactcttc atttagattg    300

gattctgaat atcagtctac atcagcatca gcatctgcgt caccatttca atctgcatgg    360

tatagtgaat ctgagataac tcagggagca cgctcaagat cgcagaacca gcaacgggat    420

catgattcaa aaagacctaa actttcctgt acaaactgta ctacctcagc tgggagaaat    480

gttggaaatg gtttaaacac attatcagat tcatcttgga ggcatagtca agttcctaga    540

tcttcatcaa tggtacttgg atcatttgga acagacttaa tgagagagag gagagatttg    600

gagagaagaa cagattcctc tattagtaat cttatggatt atagtcaccg aagtggtgat    660

ttcacaactt catcatatgt tcaagacaga gttccttcat attcacaagg agcaagacca    720

aaagaaaact caatgagcac tttacagttg aatacatcat ccacaaacca ccaattgcct    780

tctgaacatc agaccatact aagttctagg gactccagaa attctttaag atcaaatttt    840

tcttcaagag aatcagaatc ttcccgaagc aatacgcagc ctggattttc ttacagttca    900

agtagagatg aagccccaat cataagcaat tcagaaaggg ttgtttcatc tcaaagacca    960

tttcaagaat cttctgacaa tgaaggtagg cggacaacga ggagattgct gtcacgcata   1020

gcttctagca tgtcatctac ttttttttca cgaagatcta gtcaggattc cttgaataca   1080

agatcattga attctgaaaa ttcttacgtt tctccaagaa tcttgacagc ttcacagtcc   1140

cgtagtaatg taccatcagc ttctgaagtt cccgataata gggcatctga agcttctcag   1200

ggatttcgat ttcttaggcg aagatggggt ttgtcatctc ttagccacaa tcatagctct   1260

gagtcagatt cagaaaattt taaccaagaa tctgaaggta gaaatacagg accatggtta   1320

tcttcctcac ttagaaatag atgcacacct ttgttctcta gaaggaggcg agagggaaga   1380

gatgaatctt caaggatacc tacctctgat acatcatcta gatctcatat ttttagaaga   1440

gaatcaaatg aagtggttca ccttgaagca cagaatgatc ctcttggagc tgctgccaac   1500

agaccacaag catctgcagc atcaagcagt gccacaacag gtggctctac atcagattcg   1560

gctcaaggtg gaagaaatac aggaatatca gggattcttc ctggttcctt attccggttt   1620

gcagtccctc cagcacttgg gagtaatttg accgacaatg tcatgatcac agtagatatt   1680

attccttcag gttggaattc agctgatggt aaaagtgata aaactaaaag tgcgccttca   1740

agagatccag aaagattgca gaaaataaaa gagagcctcc ttttagagga ctcagaagaa   1800

gaagaaggtg acttatgtag aatttgtcaa atggcagctg catcatcatc taatttgctg   1860

atagagccat gcaagtgcac aggaagtttg cagtatgtcc accaagactg tatgaaaaag   1920

tggttacagg ccaaaattaa ctctggttct tcattagaag ctgtaaccac ctgtgaacta   1980

tgtaaagaga agttggagct taacctggag gattttgata ttcatgaact acatagagct   2040

catgcaaatg aacaagctga gtatgagttt atcagctctg gtctctacct agtggtgtta   2100

ttgcacttgt gcgaacaaag cttttctgat atgatgggaa atacaaatga accaagcaca   2160

cgtgtccgat ttattaacct tgcaagaact cttcaggcac atatggaaga tctcgaaact   2220

tcagaggatg attccgaaga agacggagac cataacagga catttgatat tgcctaactt   2280

catataagac agatggatga tctgtgaaca taagtgttta ttaaaaatgg caattaaata   2340

taaattactt ttgtggggga atgcctaata aatacattga ctatatataa aatgaatata   2400

tacatacaca tgtatgcctg tatatatata ttcattctcc agtgttgctg aattaaaatt   2460

ctgctggact ttttaacata gcaaatccga tgtttataaa ctggtaatca aaaaggtttt   2520

ttcttttagg tgagtgggaa agtattaccc ttgttttaaa tatctaagca atgcctatca   2580

accctttttt gtgttatgat tactgtagtc atatttatga aaaaaggttt gtgttttact   2640

cttgctagtg agaaaagtgg gacaaaatat acttttgaaa taaaatgcta tatggcacct   2700

aattattttt tcttttaaaa tgccttaagt tgcagtctca ttttgataat catttgcttc   2760

cagtgtttaa aaattaaaaa aagaatgggg agaaggttat gagaagagca ttattaagtt   2820

tccaaattta atttgaattc caaattcacc tagcaataaa atctaatttt taaaaagtat   2880

ataaatataa aatgtataaa tgatggatag atttttgtat tgatttgcaa aatgcagatt   2940

atatttgata ggctatagta tgtagatatt ccttttagga atattacagc tgtaaattat   3000

atgagacttg ccagtcaaat gctatttggt ttaaaaaaat tattgcaatc tcaagttaat   3060

ggaatatttt taaatcccac attcagagtt taaaacactg gttttcaatg tgttttttag   3120

tgttgtcact tgtttataga taaatatata aataacctgt ttggatcctg gtccttttta   3180

actgttcctt ggtaattctg agcatttatt tgatgactta atatttttca ctacctttgg   3240

agaacagatg aacattattc accatgaatg gatctatact gtgtggtcat gagttgtgta   3300

tacttccata acactgtatt tttcttctgt cagtaccctt aggatacact ttaaaacacc   3360

ttaaggtctg atgttatggc aacaaactac tttttcaaac ctaaatagga accatgtaat   3420

ttctcaaaag tgattgaaca gtttgcccac acttagtttg ttggtcttat gtaaaacatt   3480

ggctcaaaat aaagtacaca ctgatttatt ttactgtttg aaatgtttcc ttttaaactg   3540

gtgctcaaag aagacatcag acttcataac caagaatttt attacaattt caaatctcat   3600

tttaagcaat aatataaatg ttctaaaaca tttgctcacc tcttgccagt tacctttgca   3660

ttgtctgtct taaagcaaaa atataaaatt taagggtggt agttttaata tattctgtgg   3720

gtcctaaggg atgctttgaa tttgaagtat atatactttt aataaaattc agtatgacag   3780

ttgtcttctg cttaacccat aaaactttat ttaaaaaatt taactagatg gtacaaaaca   3840

ttcattggta tgcacataat tctgtatagt tttgttatta aatgctaaat gacagtgata   3900

acaatggctt aagctttaca gtattcttgt agttccctag taccacttag tatttaaata   3960

ttgtcatatt agcttcagat tatcatgtaa atgacggtag aggaataaga gaaaaggctt   4020

tcattggtta tcagttttaa attctgaaca aaagagacca tacactgctc actacaagaa   4080

tgcaattttc taagaaaatg tagtttaaaa tgttattctg aatatctgcc aaagaattat   4140

attgttatta ctagctagaa ccaagatgtt gaagaaagca gtttctacat tctggatgta   4200

gtaaacaagc ctgcctgtgt aatccaatta tctcttcact aatgagtaga taaggtgcct   4260

gttatagatg ttctggtata taaagaaaaa atgtaggcca agtgtggtgg ctcacgcatg   4320

taatcccagc actttgggag accaaggtgg gtggatcact tgaggtcagg agtttgagac   4380

cagcccagtc aatatggcga aaccccgtct ctaccaaaaa tacaaaaagt tagctgggtg   4440

tggtgacaga tgtctgtggt cccagctact aaggaggctg aggcaggaga attgcttgaa   4500

aacctgcaag gcggagattg gagagagcca agatcgagcc actgcactgt agcctgggca   4560

gcacagtgag actccatcat atatatatat atagcacttc attaccagag gcctcttggc   4620

ctgttgaaaa atgaaaccaa atattgaaaa ttaaatcaga gtttaaagca gctattttgg   4680

aagagctgcc attaggtaga aagtatcaaa atgtacaaaa gaaagttgta tgggagttga   4740

gtggaaggta ggatttaaga gcagcactgc ccaataaaac ttcctataat gaaaatgttc   4800

tataatgtat gttgcccagt acagtagcca ctaaccacct gtgatttgaa cacttgacaa   4860

tgtggctaat gtaattcgaa aactggattt taaactaaat ttacttaaat agcctcatgt   4920

ggctagtggc tcattggaca ttgtagttgt agacgtttga gactgttggt tttaagttgg   4980

acttaatcac tttcctaccc aaattctacc actcctttaa gaactccttt agaactcttt   5040

tagttcacat aatacgccat atttttttta ctgtgcctgt agttcttcaa ggagtggtac   5100

aatttgggta ggaaaaccag gcaggaattc cagggtagtg ttcaatattg acattagtaa   5160

tagtctatca ataataaaat agacatctca atcactatac aaaatctcag aaatgtaaag   5220

ctcttacaga gcatgcttgt gcttgtgtaa cagctggtgt aatgcctgca ttttcagtac   5280

catgtagccg cactgttaat agttttctat cactttttag ttactcatgt ctcattaatg   5340

atagtgccat taattgtgat gagtgttttc gattcatgtg gtcaataaaa agagactaca   5400

caagctggaa ctttgttgcc attagtcaag ctagtgagat agtatatcta tctatctccc   5460

cagaagaaag taagataatt gatggggtgt ggattcagaa gagggattac ttttctttga   5520

gcctcagact tctagacagt atacttcagt cagtaatgga ccacatatag aacagtgttt   5580

ccttagtaga ccatattttt actgtacctt ttctatattt agatacacaa atattgtgtt   5640

acaattgtct gcagtattca gcacagtaac atgctgtgta ggtttgggac aaaataggct   5700

ctaccatctg ggtttgtgta aatacaagct gattttcaca caagattccc taactatgca   5760

tttcttagaa cgtatcccca ttgataagtg atacgtgact aatttacgtg aaatttatac   5820

attctttatc tttcctgttt ttggtttatt gatggtgagg aaaattactc gtttcagctt   5880

tttcattttt ttactcccca aatgattttc acctttttct taaaatgtac aataaatgca   5940

ctgaaaactt tgatcactgt cactacagtt gtacttaagt gtttttcttc ggtttttgct   6000

tgcacagttt tcatgtcatt gaaggaaaaa tttataaatg cttgaggaga atgagataca   6060

tcttgtatag gggaaagtac aaaaggtatg gtggcaagag agaaatcctt aaaggggcac   6120

tataatatgt aagtgttaac ctaattgcca gctttctcta tgccatcctg gacacagcga   6180

tcatattttg tttcaaataa tttataaaca ttcattaaaa cttgagtcat ttgtgataaa   6240

atggtgtgtg taaaagtaat gaaactaaaa ttggtgtggg gtgttaaaag ttgtaaaatt   6300

ttcttcatct aaatcataaa aagatacaca ttctagagga attatctgcc aaaaaaataa   6360

caattatcaa agatatttaa atgtatggga tgtacttaaa atcacttatt ccccatttca   6420

tgtttactaa taaacatata aactaaagtg ggtcaactaa atagggaaga tacagcaggc   6480

aagacaaata ggctgggctt ttatttttat ctgcttgggc tttaagcttt ccttcattca   6540

agtgacagat tctgcctttg acgggatgct taaaatcact atattagatc taagatcatt   6600

tctaaaacct gtttttttaa tgaacctaaa gacttttcac agcagatgag tacataaaaa   6660

tgttactgga ataaggaata ccattaaagc tctaatatcc                         6700


<210>  8605
<211>  704
<212>  PRT
<213>  Homosapiens

<400>  8605

Met Glu Ser Lys Pro Ser Arg Ile Pro Arg Arg Ile Ser Val Gln Pro 
1               5                   10                  15      


Ser Ser Ser Leu Ser Ala Arg Met Met Ser Gly Ser Arg Gly Ser Ser 
            20                  25                  30          


Leu Asn Asp Thr Tyr His Ser Arg Asp Ser Ser Phe Arg Leu Asp Ser 
        35                  40                  45              


Glu Tyr Gln Ser Thr Ser Ala Ser Ala Ser Ala Ser Pro Phe Gln Ser 
    50                  55                  60                  


Ala Trp Tyr Ser Glu Ser Glu Ile Thr Gln Gly Ala Arg Ser Arg Ser 
65                  70                  75                  80  


Gln Asn Gln Gln Arg Asp His Asp Ser Lys Arg Pro Lys Leu Ser Cys 
                85                  90                  95      


Thr Asn Cys Thr Thr Ser Ala Gly Arg Asn Val Gly Asn Gly Leu Asn 
            100                 105                 110         


Thr Leu Ser Asp Ser Ser Trp Arg His Ser Gln Val Pro Arg Ser Ser 
        115                 120                 125             


Ser Met Val Leu Gly Ser Phe Gly Thr Asp Leu Met Arg Glu Arg Arg 
    130                 135                 140                 


Asp Leu Glu Arg Arg Thr Asp Ser Ser Ile Ser Asn Leu Met Asp Tyr 
145                 150                 155                 160 


Ser His Arg Ser Gly Asp Phe Thr Thr Ser Ser Tyr Val Gln Asp Arg 
                165                 170                 175     


Val Pro Ser Tyr Ser Gln Gly Ala Arg Pro Lys Glu Asn Ser Met Ser 
            180                 185                 190         


Thr Leu Gln Leu Asn Thr Ser Ser Thr Asn His Gln Leu Pro Ser Glu 
        195                 200                 205             


His Gln Thr Ile Leu Ser Ser Arg Asp Ser Arg Asn Ser Leu Arg Ser 
    210                 215                 220                 


Asn Phe Ser Ser Arg Glu Ser Glu Ser Ser Arg Ser Asn Thr Gln Pro 
225                 230                 235                 240 


Gly Phe Ser Tyr Ser Ser Ser Arg Asp Glu Ala Pro Ile Ile Ser Asn 
                245                 250                 255     


Ser Glu Arg Val Val Ser Ser Gln Arg Pro Phe Gln Glu Ser Ser Asp 
            260                 265                 270         


Asn Glu Gly Arg Arg Thr Thr Arg Arg Leu Leu Ser Arg Ile Ala Ser 
        275                 280                 285             


Ser Met Ser Ser Thr Phe Phe Ser Arg Arg Ser Ser Gln Asp Ser Leu 
    290                 295                 300                 


Asn Thr Arg Ser Leu Asn Ser Glu Asn Ser Tyr Val Ser Pro Arg Ile 
305                 310                 315                 320 


Leu Thr Ala Ser Gln Ser Arg Ser Asn Val Pro Ser Ala Ser Glu Val 
                325                 330                 335     


Pro Asp Asn Arg Ala Ser Glu Ala Ser Gln Gly Phe Arg Phe Leu Arg 
            340                 345                 350         


Arg Arg Trp Gly Leu Ser Ser Leu Ser His Asn His Ser Ser Glu Ser 
        355                 360                 365             


Asp Ser Glu Asn Phe Asn Gln Glu Ser Glu Gly Arg Asn Thr Gly Pro 
    370                 375                 380                 


Trp Leu Ser Ser Ser Leu Arg Asn Arg Cys Thr Pro Leu Phe Ser Arg 
385                 390                 395                 400 


Arg Arg Arg Glu Gly Arg Asp Glu Ser Ser Arg Ile Pro Thr Ser Asp 
                405                 410                 415     


Thr Ser Ser Arg Ser His Ile Phe Arg Arg Glu Ser Asn Glu Val Val 
            420                 425                 430         


His Leu Glu Ala Gln Asn Asp Pro Leu Gly Ala Ala Ala Asn Arg Pro 
        435                 440                 445             


Gln Ala Ser Ala Ala Ser Ser Ser Ala Thr Thr Gly Gly Ser Thr Ser 
    450                 455                 460                 


Asp Ser Ala Gln Gly Gly Arg Asn Thr Gly Ile Ser Gly Ile Leu Pro 
465                 470                 475                 480 


Gly Ser Leu Phe Arg Phe Ala Val Pro Pro Ala Leu Gly Ser Asn Leu 
                485                 490                 495     


Thr Asp Asn Val Met Ile Thr Val Asp Ile Ile Pro Ser Gly Trp Asn 
            500                 505                 510         


Ser Ala Asp Gly Lys Ser Asp Lys Thr Lys Ser Ala Pro Ser Arg Asp 
        515                 520                 525             


Pro Glu Arg Leu Gln Lys Ile Lys Glu Ser Leu Leu Leu Glu Asp Ser 
    530                 535                 540                 


Glu Glu Glu Glu Gly Asp Leu Cys Arg Ile Cys Gln Met Ala Ala Ala 
545                 550                 555                 560 


Ser Ser Ser Asn Leu Leu Ile Glu Pro Cys Lys Cys Thr Gly Ser Leu 
                565                 570                 575     


Gln Tyr Val His Gln Asp Cys Met Lys Lys Trp Leu Gln Ala Lys Ile 
            580                 585                 590         


Asn Ser Gly Ser Ser Leu Glu Ala Val Thr Thr Cys Glu Leu Cys Lys 
        595                 600                 605             


Glu Lys Leu Glu Leu Asn Leu Glu Asp Phe Asp Ile His Glu Leu His 
    610                 615                 620                 


Arg Ala His Ala Asn Glu Gln Ala Glu Tyr Glu Phe Ile Ser Ser Gly 
625                 630                 635                 640 


Leu Tyr Leu Val Val Leu Leu His Leu Cys Glu Gln Ser Phe Ser Asp 
                645                 650                 655     


Met Met Gly Asn Thr Asn Glu Pro Ser Thr Arg Val Arg Phe Ile Asn 
            660                 665                 670         


Leu Ala Arg Thr Leu Gln Ala His Met Glu Asp Leu Glu Thr Ser Glu 
        675                 680                 685             


Asp Asp Ser Glu Glu Asp Gly Asp His Asn Arg Thr Phe Asp Ile Ala 
    690                 695                 700                 


<210>  8606
<211>  740
<212>  DNA
<213>  Homosapiens

<400>  8606
caagaatcgt ctacattttg acattttatt gtaggaaaat aattttataa tgcaaaatct     60

gtcaaatatc ttaaaacttt tttagataat ttgtaatttg ttgtagtcaa attacaaatt    120

atggagagct tcacattaca agaatgagct tgacatggca tctgccctcc acaactcact    180

gtttagtcat cagactaatg tataaacaac tattattatc ttaatatgac tgtacagtgg    240

ttctgtggga gcatagggga ggggtgctta atcttggaaa ttttacagga tttatttatt    300

tattgcctga actaagatgt gaaggctcac taggactttg ataaagaaac tgcaaagtca    360

tgatattatg gtttgtttta ggaattcatg atttgttcct gtagctgaaa catacattga    420

atggtaagtt agagcccgac ataaaagact ttctgtactg tactagaaaa ttagtgtctg    480

ggtgtggtgg ctcactcctg taatcccgtc actttgggag gccaaggtgg gaggatcgct    540

taaggctggg agttcagcca ggccacaaag accccatctc tacgggcatg gtggtgcggg    600

tgtagtggtg cgcactgcta ctactagcta cttgggctgc tgaggcagga gaatggcatg    660

aaccctggag gcagagcttg cagtgaatca agatcacgcc actgcactct agcctgggcg    720

acagagcgag actctgtctc                                                740


<210>  8607
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  8607

Lys Ile Ser Val Trp Val Trp Trp Leu Thr Pro Val Ile Pro Ser Leu 
1               5                   10                  15      


Trp Glu Ala Lys Val Gly Gly Ser Leu Lys Ala Gly Ser Ser Ala Arg 
            20                  25                  30          


Pro Gln Arg Pro His Leu Tyr Gly His Gly Gly Ala Gly Val Val Val 
        35                  40                  45              


Arg Thr Ala Thr Thr Ser Tyr Leu Gly Cys 
    50                  55              


<210>  8608
<211>  5296
<212>  DNA
<213>  Homosapiens

<400>  8608
ctctccggcc gcgcagccgc tgccgcccac ccgcacccgc cgtcatgctc cgggccgcgc     60

tgcccgcgct cctgctgccg ttgctgggcc tcgccgctgc tgccgtcgcg gactgtcctt    120

catctacttg gattcagttc caagacagtt gttacatttt tctccaagaa gccatcaaag    180

tagaaagcat agaggatgtc agaaatcagt gtactgacca tggagcggac atgataagca    240

tacataatga agaagaaaat gcttttatac tggatacttt gaaaaagcaa tggaaaggcc    300

cagatgatat cctactaggc atgttttatg acacagatga tgcgagtttc aagtggtttg    360

ataattcaaa tatgacattt gataagtgga cagaccaaga tgatgatgag gatttagttg    420

acacctgtgc ttttctgcac atcaagacag gtgaatggaa aaaaggaaat tgtgaagttt    480

cttctgtgga aggaacacta tgcaaaacag ctatcccata caaaaggaaa tatttatcag    540

ataaccacat tttaatatca gcattggtga ttgctagcac ggtaattttg acagttttgg    600

gagcaatcat ttggttcctg tacaaaaaac attctgattc tcgtttcacc acagtttttt    660

caaccgcacc ccaatcacct tataatgaag actgtgtttt ggtagttgga gaagaaaatg    720

aatatcctgt tcaatttgac taagtttttg gtaatcttgc actaagacat caacaaaatg    780

ccctggcaga gataacttgg gaaagatttt aatataaaac ttgacattgg atattagagc    840

tttaatggta ttccttattc cagtaacatt tttatgtact catctgctgt gaaaagtctt    900

taggttcatt aaaaaaacag gttttagaaa tgatcttaga tctaatatag tgattttaag    960

catcccgtca aaggcagaat ctgtcacttg aatgaaggaa agcttaaagc ccaagcagat   1020

aaaaataaaa gcccagccta tttgtcttgc ctgctgtatc ttccctattt agttgaccca   1080

ctttagttta tatgtttatt agtaaacatg aaatggggaa taagtgattt taagtacatc   1140

ccatacattt aaatatcttt gataattgtt atttttttgg cagataattc ctctagaatg   1200

tgtatctttt tatgatttag atgaagaaaa ttttacaact tttaacaccc cacaccaatt   1260

ttagtttcat tacttttaca cacaccattt tatcacaaat gactcaagtt ttaatgaatg   1320

tttataaatt atttgaaaca aaatatgatc gctgtgtcca ggatggcata gagaaagctg   1380

gcaattaggt taacacttac atattatagt gcccctttaa ggatttctct cttgccacca   1440

taccttttgt actttcccct atacaagatg tatctcattc tcctcaagca tttataaatt   1500

tttccttcaa tgacatgaaa actgtgcaag caaaaaccga agaaaaacac ttaagtacaa   1560

ctgtagtgac agtgatcaaa gttttcagtg catttattgt acattttaag aaaaaggtga   1620

aaatcatttg gggagtaaaa aaatgaaaaa gctgaaacga gtaattttcc tcaccatcaa   1680

taaaccaaaa acaggaaaga taaagaatgt ataaatttca cgtaaattag tcacgtatca   1740

cttatcaatg gggatacgtt ctaagaaatg catagttagg gaatcttgtg tgaaaatcag   1800

cttgtattta cacaaaccca gatggtagag cctattttgt cccaaaccta cacagcatgt   1860

tactgtgctg aatactgcag acaattgtaa cacaatattt gtgtatctaa atatagaaaa   1920

ggtacagtaa aaatatggtc tactaaggaa acactgttct atatgtggtc cattactgac   1980

tgaagtatac tgtctagaag tctgaggctc aaagaaaagt aatccctctt ctgaatccac   2040

accccatcaa ttatcttact ttcttctggg gagatagata gatatactat ctcactagct   2100

tgactaatgg caacaaagtt ccagcttgtg tagtctcttt ttattgacca catgaatcga   2160

aaacactcat cacaattaat ggcactatca ttaatgagac atgagtaact aaaaagtgat   2220

agaaaactat taacagtgcg gctacatggt actgaaaatg caggcattac accagctgtt   2280

acacaagcac aagcatgctc tgtaagagct ttacatttct gagattttgt atagtgattg   2340

agatgtctat tttattattg atagactatt actaatgtca atattgaaca ctaccctgga   2400

attcctgcct ggttttccta cccaaattgt accactcctt gaagaactac aggcacagta   2460

aaaaaaatat ggcgtattat gtgaactaaa agagttctaa aggagttctt aaaggagtgg   2520

tagaatttgg gtaggaaagt gattaagtcc aacttaaaac caacagtctc aaacgtctac   2580

aactacaatg tccaatgagc cactagccac atgaggctat ttaagtaaat ttagtttaaa   2640

atccagtttt cgaattacat tagccacatt gtcaagtgtt caaatcacag gtggttagtg   2700

gctactgtac tgggcaacat acattataga acattttcat tataggaagt tttattgggc   2760

agtgctgctc ttaaatccta ccttccactc aactcccata caactttctt ttgtacattt   2820

tgatactttc tacctaatgg cagctcttcc aaaatagctg ctttaaactc tgatttaatt   2880

ttcaatattt ggtttcattt ttcaacaggc caagaggcct ctggtaatga agtgctatat   2940

atatatatat gatggagtct cactgtgctg cccaggctac agtgcagtgg ctcgatcttg   3000

gctctctcca atctccgcct tgcaggtttt caagcaattc tcctgcctca gcctccttag   3060

tagctgggac cacagacatc tgtcaccaca cccagctaac tttttgtatt tttggtagag   3120

acggggtttc gccatattga ctgggctggt ctcaaactcc tgacctcaag tgatccaccc   3180

accttggtct cccaaagtgc tgggattaca tgcgtgagcc accacacttg gcctacattt   3240

tttctttata taccagaaca tctataacag gcaccttatc tactcattag tgaagagata   3300

attggattac acaggcaggc ttgtttacta catccagaat gtagaaactg ctttcttcaa   3360

catcttggtt ctagctagta ataacaatat aattctttgg cagatattca gaataacatt   3420

ttaaactaca ttttcttaga aaattgcatt cttgtagtga gcagtgtatg gtctcttttg   3480

ttcagaattt aaaactgata accaatgaaa gccttttctc ttattcctct accgtcattt   3540

acatgataat ctgaagctaa tatgacaata tttaaatact aagtggtact agggaactac   3600

aagaatactg taaagcttaa gccattgtta tcactgtcat ttagcattta ataacaaaac   3660

tatacagaat tatgtgcata ccaatgaatg ttttgtacca tctagttaaa ttttttaaat   3720

aaagttttat gggttaagca gaagacaact gtcatactga attttattaa aagtatatat   3780

acttcaaatt caaagcatcc cttaggaccc acagaatata ttaaaactac cacccttaaa   3840

ttttatattt ttgctttaag acagacaatg caaaggtaac tggcaagagg tgagcaaatg   3900

ttttagaaca tttatattat tgcttaaaat gagatttgaa attgtaataa aattcttggt   3960

tatgaagtct gatgtcttct ttgagcacca gtttaaaagg aaacatttca aacagtaaaa   4020

taaatcagtg tgtactttat tttgagccaa tgttttacat aagaccaaca aactaagtgt   4080

gggcaaactg ttcaatcact tttgagaaat tacatggttc ctatttaggt ttgaaaaagt   4140

agtttgttgc cataacatca gaccttaagg tgttttaaag tgtatcctaa gggtactgac   4200

agaagaaaaa tacagtgtta tggaagtata cacaactcat gaccacacag tatagatcca   4260

ttcatggtga ataatgttca tctgttctcc aaaggtagtg aaaaatatta agtcatcaaa   4320

taaatgctca gaattaccaa ggaacagtta aaaaggacca ggatccaaac aggttattta   4380

tatatttatc tataaacaag tgacaacact aaaaaacaca ttgaaaacca gtgttttaaa   4440

ctctgaatgt gggatttaaa aatattccat taacttgaga ttgcaataat ttttttaaac   4500

caaatagcat ttgactggca agtctcatat aatttacagc tgtaatattc ctaaaaggaa   4560

tatctacata ctatagccta tcaaatataa tctgcatttt gcaaatcaat acaaaaatct   4620

atccatcatt tatacatttt atatttatat actttttaaa aattagattt tattgctagg   4680

tgaatttgga attcaaatta aatttggaaa cttaataatg ctcttctcat aaccttctcc   4740

ccattctttt tttaattttt aaacactgga agcaaatgat tatcaaaatg agactgcaac   4800

ttaaggcatt ttaaaagaaa aaataattag gtgccatata gcattttatt tcaaaagtat   4860

attttgtccc acttttctca ctagcaagag taaaacacaa accttttttc ataaatatga   4920

ctacagtaat cataacacaa aaaagggttg ataggcattg cttagatatt taaaacaagg   4980

gtaatacttt cccactcacc taaaagaaaa aacctttttg attaccagtt tataaacatc   5040

ggatttgcta tgttaaaaag tccagcagaa ttttaattca gcaacactgg agaatgaata   5100

tatatataca ggcatacatg tgtatgtata tattcatttt atatatagtc aatgtattta   5160

ttaggcattc ccccacaaaa gtaatttata tttaattgcc atttttaata aacacttatg   5220

ttcacagatc atccatctgt cttatatgaa gttaggcaat atcaaatgtc ctgttatggt   5280

ctccgtcttc ttcgga                                                   5296


<210>  8609
<211>  232
<212>  PRT
<213>  Homosapiens

<400>  8609

Met Leu Arg Ala Ala Leu Pro Ala Leu Leu Leu Pro Leu Leu Gly Leu 
1               5                   10                  15      


Ala Ala Ala Ala Val Ala Asp Cys Pro Ser Ser Thr Trp Ile Gln Phe 
            20                  25                  30          


Gln Asp Ser Cys Tyr Ile Phe Leu Gln Glu Ala Ile Lys Val Glu Ser 
        35                  40                  45              


Ile Glu Asp Val Arg Asn Gln Cys Thr Asp His Gly Ala Asp Met Ile 
    50                  55                  60                  


Ser Ile His Asn Glu Glu Glu Asn Ala Phe Ile Leu Asp Thr Leu Lys 
65                  70                  75                  80  


Lys Gln Trp Lys Gly Pro Asp Asp Ile Leu Leu Gly Met Phe Tyr Asp 
                85                  90                  95      


Thr Asp Asp Ala Ser Phe Lys Trp Phe Asp Asn Ser Asn Met Thr Phe 
            100                 105                 110         


Asp Lys Trp Thr Asp Gln Asp Asp Asp Glu Asp Leu Val Asp Thr Cys 
        115                 120                 125             


Ala Phe Leu His Ile Lys Thr Gly Glu Trp Lys Lys Gly Asn Cys Glu 
    130                 135                 140                 


Val Ser Ser Val Glu Gly Thr Leu Cys Lys Thr Ala Ile Pro Tyr Lys 
145                 150                 155                 160 


Arg Lys Tyr Leu Ser Asp Asn His Ile Leu Ile Ser Ala Leu Val Ile 
                165                 170                 175     


Ala Ser Thr Val Ile Leu Thr Val Leu Gly Ala Ile Ile Trp Phe Leu 
            180                 185                 190         


Tyr Lys Lys His Ser Asp Ser Arg Phe Thr Thr Val Phe Ser Thr Ala 
        195                 200                 205             


Pro Gln Ser Pro Tyr Asn Glu Asp Cys Val Leu Val Val Gly Glu Glu 
    210                 215                 220                 


Asn Glu Tyr Pro Val Gln Phe Asp 
225                 230         


<210>  8610
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  8610
aggatgagga caggctgggc gacccctcgc cgcccggcgg ggctcctcat gctgctcttc     60

tggttcttcg atctcgcgga gccctctggc cgcgcagcta atgacccctt caccatcgtc    120

catggaaata cgggcaagtg catcaagcca gtgtatggct ggatagtagc agacgactgt    180

gatgaaactg aggacaagtt atggaagtgg gtgtcccagc atcggctctt tcatttgcac    240

tcccaaaagt gccttggcct cgatattacc aaatcggtaa atgagctgag aatgttcagc    300

tgtgactcca gtgccatgct gtggtggaaa tgtgagcacc actctctgta cggagctgcc    360

cggtaccggc tggctctgaa ggatggacat ggcacagcaa tctcaaatgc atctgatgtc    420

tggaagaaag gaggctcaga ggaaagcctt tgtgaccagc cttatcatga gatctatacc    480

agagatggga actcttatgg gagaccttgt gaatttccat tcttaattga tgggacctgg    540

catcatgatt gcattcttga tgaagatcat agtgggccat ggtgtgccac caccttaaat    600

tatgaatatg accgaaagtg gggcatctgc ttaaagcctg aaaacggttg tgaagataat    660

tgggaaaaga acgagcagtt tggaagttgc taccaattta atactcagac ggctctttct    720

tggaaagaag cttatgtttc atgtcagaat caaggagctg atttactgag catcaacagt    780

gctgctgaat taacttacct taaagaaaaa gaaggcattg ctaagatttt ctggattggt    840

ttaaatcagc tatactctgc tagaggctgg gaatggtcag accacaaacc attaaacttt    900

ctcaactggg atccagacag gcccagtgca cctactatag gtggctccag ctgtgcaaga    960

atggatgctg agtctggtct gtggcagagc ttttcctgtg aagctcaact gccctatgtc   1020

tgcaggaaac cattaaataa tacagtggag ttaacagatg tctggacata ctcagatacc   1080

cgctgtgatg caggctggct gccaaataat ggattttgct atctgctggt aaatgaaagt   1140

aattcctggg ataaggcaca tgcgaaatgc aaagccttca gtagtgacct aatcagcatt   1200

cattctctag cagatgtgga ggtggttgtc acaaaactcc ataatgagga tatcaaagaa   1260

gaagtgtgga taggccttaa gaacataaac ataccaactt tatttcagtg gtcagatggt   1320

actgaagtta ctctaacata ttgggatgag aatgagccaa atgttcccta caataagacg   1380

cccaactgtg tttcctactt aggagagcta ggtcagtgga aagtccaatc atgtgaggag   1440

aaactaaaat atgtatgcaa gagaaaggga gaaaaactga atgacgcaag ttctgataag   1500

atgtgtcctc cagatgaggg ctggaagaga catggagaaa cctgttacaa gatttatgag   1560

gatgaggtcc cttttggaac aaactgcaat ctgactatca ctagcagatt tgagcaagaa   1620

tacctaaatg atttgatgaa aaagtatgat aaatctctaa gaaaatactt ctggactggc   1680

ctgagagatg tagattcttg tggagagtat aactgggcaa ctgttggtgg aagaaggcgg   1740

gctgtaacct tttccaactg gaattttctt gagccagctt ccccgggcgg ctgcgtggct   1800

atgtctactg gaaagtctgt tggaaagtgg gaggtgaagg actgcagaag cttcaaagca   1860

ctttcaattt gcaagaaaat gagtggaccc cttgggcctg aagaagcatc ccctaagcct   1920

gatgacccct gtcctgaagg ctggcagagt ttccccgcaa gtctttcttg ttataaggta   1980

ttccatgcag aaagaattgt aagaaagagg aactgggaag aagctgaacg attctgccaa   2040

gcccttggag cacacctttc tagcttcagc catgtggatg aaataaagga atttcttcac   2100

tttttaacgg accagttcag tggccagcat tggctgtgga ttggtttgaa taaaaggagc   2160

ccagatttac aaggatcctg gcaatggagt gatcgtacac cagtgtctac tattatcatg   2220

ccaaatgagt ttcagcagga ttatgacatc agagactgtg ctgctgtcaa ggtatttcat   2280

aggccatggc gaagaggctg gcatttctat gatgatagag aatttattta tttgaggcct   2340

tttgcttgtg atacaaaact tgaatgggtg tgccaaattc caaaaggccg tactccaaaa   2400

acaccagact ggtacaatcc agaccgtgct ggaattcatg gacctccact tataattgaa   2460

ggaagtgaat attggtttgt tgctgatctt cacctaaact atgaagaagc cgtcctgtac   2520

tgtgccagca atcacagctt tcttgcaact ataacatctt ttgtgggact aaaagccatc   2580

aaaaacaaaa tagcaaatat atctggtgat ggacagaagt ggtggataag aattagcgag   2640

tggccaatag atgatcattt tacatactca cgatatccat ggcaccgctt tcctgtgaca   2700

tttggagagg aatgcttgta catgtctgcc aagacttggc ttatcgactt aggtaaacca   2760

acagactgta gtaccaagtt gcccttcatc tgtgaaaaat ataatgtttc ttcgttagag   2820

aaatacagcc cagattctgc agctaaagtg caatgttctg agcaatggat tccttttcag   2880

aataagtgtt ttctaaagat caaacccgtg tctctcacat tttctcaagc aagcgatacc   2940

tgtcactcct atggtggcac ccttccttca gtgttgagcc agattgaaca agactttatt   3000

acatccttgc ttccggatat ggaagctact ttatggattg gtttgcgctg gactgcctat   3060

gaaaagataa acaaatggac agataacaga gagctgacgt acagtaactt tcacccatta   3120

ttggttagtg ggaggctgag aataccagaa aatttttttg aggaagagtc tcgctaccac   3180

tgtgccctaa tactcaacct ccaaaaatca ccgtttactg ggacgtggaa ttttacatcc   3240

tgcagtgaac gccactttgt gtctctctgt cagaaatatt cagaagttaa aagcagacag   3300

acgttgcaga atgcttcaga aactgtaaag tatctaaata atctgtacaa aataatccca   3360

aagactctga cttggcacag tgctaaaagg gagtgtctga aaagtaacat gcagctggtg   3420

agcatcacgg acccttacca gcaggcattc ctcagtgtgc aggcgctcct tcacaactct   3480

tccttatgga tcggactctt cagtcaagat gatgaactca actttggttg gtcagatggg   3540

aaacgtcttc attttagtcg ctgggctgaa actaatgggc aactcgaaga ctgtgtagta   3600

ttagacactg atggattctg gaaaacagtt gattgcaatg acaatcaacc aggtgctatt   3660

tgctactatt caggaaatga gactgaaaaa gaggtcaaac cagttgacag tgttaaatgt   3720

ccatctcctg ttctaaatac tccgtggata ccatttcaga actgttgcta caatttcata   3780

ataacaaaga ataggcatat ggcaacaaca caggatgaag ttcatactaa atgccagaaa   3840

ctgaatccaa aatcacatat tctgagtatt cgagatgaaa aggagaataa ctttgttctt   3900

gagcaactgc tgtacttcaa ttatatggct tcatgggtca tgttaggaat aacttataga   3960

aataagtctc ttatgtggtt tgataagacc ccactgtcat atacacattg gagagcagga   4020

agaccaacta taaaaaatga gaagtttttg gctggtttaa gtactgacgg cttctgggat   4080

attcaaacct ttaaagttat tgaagaagca gtttattttc accagcacag cattcttgct   4140

tgtaaaattg aaatggttga ctacaaagaa gaatataata ctacactgcc acagtttatg   4200

ccatatgaag atggtattta cagtgttatt caaaaaaagg taacatggta tgaagcatta   4260

aacatgtgtt ctcaaagtgg aggtcacttg gcaagcgttc acaaccaaaa tggccagctc   4320

tttctggaag atattgtaaa acgtgatgga tttccactat gggttgggct ctcaagtcat   4380

gatggaagtg aatcaagttt tgaatggtct gatggtagta catttgacta tatcccatgg   4440

aaaggccaaa catctcctgg aaattgtgtt ctcttggatc caaaaggaac ttggaaacat   4500

gaaaaatgca actctgttaa ggatggtgct atttgttata aacctacaaa atctaaaaag   4560

ctgtcccgtc ttacatattc atcaagatgt ccagcagcaa aagagaatgg gtcacggtgg   4620

atccagtaca agggtcactg ttacaagtct gatcaggcat tgcacagttt ttcagaggcc   4680

aaaaaattgt gttcaaaaca tgatcactct gcaactatcg tttccataaa agatgaagat   4740

gagaataaat ttgtgagcag actgatgagg gaaaataata acattaccat gagagtttgg   4800

cttggattat ctcaacattc tgttgactgt ccttcatcta cttggattca gttccaagac   4860

agttgttaca tttttctcca agaagccatc aaagtagaaa gcatagagga tgtcagaaat   4920

cagtgtactg accatggagc ggacatgata agcatacata atgaagaaga aaatgctttt   4980

atactggata ctttgaaaaa gcaatggaaa ggcccagatg atatcctact aggcatgttt   5040

tatgacacag atgatgcgag tttcaagtgg tttgataatt caaatatgac atttgataag   5100

tggacagacc aagatgatga tgaggattta gttgacacct gtgcttttct gcacatcaag   5160

acaggtgaat ggaaaaaagg aaattgtgaa gtttcttctg tggaaggaac actatgcaaa   5220

acagctatcc catacaaaag gaaatattta tcagataacc acattttaat atcagcattg   5280

gtgattgcta gcacggtaat tttgacagtt ttgggagcaa tcatttggtt cctgtacaaa   5340

aaacattctg attctcgttt caccacagtt ttttcaaccg caccccaatc accttataat   5400

gaagactgtg ttttggtagt tggagaagaa aatgaatatc ctgttcaatt tgactaagtt   5460

tttggtaatc ttgcactaag acatcaacaa aatgccctgg cagagataac ttgggaaaga   5520

ttttaatata aaacttgaca ttggatatta gagctttaat ggtattcctt attccagtaa   5580

catttttatg tactcatctg ctgtgaaaag tctttaggtt cattaaaaaa acaggtttta   5640

gaaatgatct tagatctaat atagtgattt taagcatccc gtcaaaggca gaatctgtca   5700

cttgaatgaa ggaaagctta aagcccaagc agataaaaat aaaagcccag cctatttgtc   5760

ttgcctgctg tatcttccct atttagttga cccactttag tttatatgtt tattagtaaa   5820

catgaaatgg ggaataagtg attttaagta catcccatac atttaaatat ctttgataat   5880

tgttattttt ttggcagata attcctctag aatgtgtatc tttttatgat ttagatgaag   5940

aaaattttac aacttttaac accccacacc aattttagtt tcattacttt tacacacacc   6000

attttatcac aaatgactca agttttaatg aatgtttata aattatttga aacaaaatat   6060

gatcgctgtg tccaggatgg catagagaaa gctggcaatt aggttaacac ttacatatta   6120

tagtgcccct ttaaggattt ctctcttgcc accatacctt ttgtactttc ccctatacaa   6180

gatgtatctc attctcctca agcatttata aatttttcct tcaatgacat gaaaactgtg   6240

caagcaaaaa ccgaagaaaa acacttaagt acaactgtag tgacagtgat caaagttttc   6300

agtgcattta ttgtacattt taagaaaaag gtgaaaatca tttggggagt aaaaaaatga   6360

aaaagctgaa acgagtaatt ttcctcacca tcaataaacc aaaaacagga aagataaaga   6420

atgtataaat ttcacgtaaa ttagtcacgt atcacttatc aatggggata cgttctaaga   6480

aatgcatagt tagggaatct tgtgtgaaaa tcagcttgta tttacacaaa cccagatggt   6540

agagcctatt ttgtcccaaa cctacacagc atgttactgt gctgaatact gcagacaatt   6600

gtaacacaat atttgtgtat ctaaatatag aaaaggtaca gtaaaaatat ggtctactaa   6660

ggaaacactg ttctatatgt ggtccattac tgactgaagt atactgtcta gaagtctgag   6720

gctcaaagaa aagtaatccc tcttctgaat ccacacccca tcaattatct tactttcttc   6780

tggggagata gatagatata ctatctcact agcttgacta atggcaacaa agttccagct   6840

tgtgtagtct ctttttattg accacatgaa tcgaaaacac tcatcacaat taatggcact   6900

atcattaatg agacatgagt aactaaaaag tgatagaaaa ctattaacag tgcggctaca   6960

tggtactgaa aatgcaggca ttacaccagc tgttacacaa gcacaagcat gctctgtaag   7020

agctttacat ttctgagatt ttgtatagtg attgagatgt ctattttatt attgatagac   7080

tattactaat gtcaatattg aacactaccc tggaattcct gcctggtttt cctacccaaa   7140

ttgtaccact ccttgaagaa ctacaggcac agtaaaaaaa atatggcgta ttatgtgaac   7200

taaaagagtt ctaaaggagt tcttaaagga gtggtagaat ttgggtagga aagtgattaa   7260

gtccaactta aaaccaacag tctcaaacgt ctacaactac aatgtccaat gagccactag   7320

ccacatgagg ctatttaagt aaatttagtt taaaatccag ttttcgaatt acattagcca   7380

cattgtcaag tgttcaaatc acaggtggtt agtggctact gtactgggca acatacatta   7440

tagaacattt tcattatagg aagttttatt gggcagtgct gctcttaaat cctaccttcc   7500

actcaactcc catacaactt tcttttgtac attttgatac tttctaccta atggcagctc   7560

ttccaaaata gctgctttaa actctgattt aattttcaat atttggtttc atttttcaac   7620

aggccaagag gcctctggta atgaagtgct atatatatat atatgatgga gtctcactgt   7680

gctgcccagg ctacagtgca gtggctcgat cttggctctc tccaatctcc gccttgcagg   7740

ttttcaagca attctcctgc ctcagcctcc ttagtagctg ggaccacaga catctgtcac   7800

cacacccagc taactttttg tatttttggt agagacgggg tttcgccata ttgactgggc   7860

tggtctcaaa ctcctgacct caagtgatcc acccaccttg gtctcccaaa gtgctgggat   7920

tacatgcgtg agccaccaca cttggcctac attttttctt tatataccag aacatctata   7980

acaggcacct tatctactca ttagtgaaga gataattgga ttacacaggc aggcttgttt   8040

actacatcca gaatgtagaa actgctttct tcaacatctt ggttctagct agtaataaca   8100

atataattct ttggcagata ttcagaataa cattttaaac tacattttct tagaaaattg   8160

cattcttgta gtgagcagtg tatggtctct tt                                 8192


<210>  8611
<211>  1817
<212>  PRT
<213>  Homosapiens

<400>  8611

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Cys Pro  Ser Ser Thr Trp Ile  Gln Phe Gln Asp Ser  Cys Tyr Ile 
    1610                 1615                 1620             


Phe Leu  Gln Glu Ala Ile Lys  Val Glu Ser Ile Glu  Asp Val Arg 
    1625                 1630                 1635             


Asn Gln  Cys Thr Asp His Gly  Ala Asp Met Ile Ser  Ile His Asn 
    1640                 1645                 1650             


Glu Glu  Glu Asn Ala Phe Ile  Leu Asp Thr Leu Lys  Lys Gln Trp 
    1655                 1660                 1665             


Lys Gly  Pro Asp Asp Ile Leu  Leu Gly Met Phe Tyr  Asp Thr Asp 
    1670                 1675                 1680             


Asp Ala  Ser Phe Lys Trp Phe  Asp Asn Ser Asn Met  Thr Phe Asp 
    1685                 1690                 1695             


Lys Trp  Thr Asp Gln Asp Asp  Asp Glu Asp Leu Val  Asp Thr Cys 
    1700                 1705                 1710             


Ala Phe  Leu His Ile Lys Thr  Gly Glu Trp Lys Lys  Gly Asn Cys 
    1715                 1720                 1725             


Glu Val  Ser Ser Val Glu Gly  Thr Leu Cys Lys Thr  Ala Ile Pro 
    1730                 1735                 1740             


Tyr Lys  Arg Lys Tyr Leu Ser  Asp Asn His Ile Leu  Ile Ser Ala 
    1745                 1750                 1755             


Leu Val  Ile Ala Ser Thr Val  Ile Leu Thr Val Leu  Gly Ala Ile 
    1760                 1765                 1770             


Ile Trp  Phe Leu Tyr Lys Lys  His Ser Asp Ser Arg  Phe Thr Thr 
    1775                 1780                 1785             


Val Phe  Ser Thr Ala Pro Gln  Ser Pro Tyr Asn Glu  Asp Cys Val 
    1790                 1795                 1800             


Leu Val  Val Gly Glu Glu Asn  Glu Tyr Pro Val Gln  Phe Asp 
    1805                 1810                 1815         


<210>  8612
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  8612
aggatgagga caggctgggc gacccctcgc cgcccggcgg ggctcctcat gctgctcttc     60

tggttcttcg atctcgcgga gccctctggc cgcgcagcta atgacccctt caccatcgtc    120

catggaaata cgggcaagtg catcaagcca gtgtatggct ggatagtagc agacgactgt    180

gatgaaactg aggacaagtt atggaagtgg gtgtcccagc atcggctctt tcatttgcac    240

tcccaaaagt gccttggcct cgatattacc aaatcggtaa atgagctgag aatgttcagc    300

tgtgactcca gtgccatgct gtggtggaaa tgtgagcacc actctctgta cggagctgcc    360

cggtaccggc tggctctgaa ggatggacat ggcacagcaa tctcaaatgc atctgatgtc    420

tggaagaaag gaggctcaga ggaaagcctt tgtgaccagc cttatcatga gatctatacc    480

agagatggga actcttatgg gagaccttgt gaatttccat tcttaattga tgggacctgg    540

catcatgatt gcattcttga tgaagatcat agtgggccat ggtgtgccac caccttaaat    600

tatgaatatg accgaaagtg gggcatctgc ttaaagcctg aaaacggttg tgaagataat    660

tgggaaaaga acgagcagtt tggaagttgc taccaattta atactcagac ggctctttct    720

tggaaagaag cttatgtttc atgtcagaat caaggagctg atttactgag catcaacagt    780

gctgctgaat taacttacct taaagaaaaa gaaggcattg ctaagatttt ctggattggt    840

ttaaatcagc tatactctgc tagaggctgg gaatggtcag accacaaacc attaaacttt    900

ctcaactggg atccagacag gcccagtgca cctactatag gtggctccag ctgtgcaaga    960

atggatgctg agtctggtct gtggcagagc ttttcctgtg aagctcaact gccctatgtc   1020

tgcaggaaac cattaaataa tacagtggag ttaacagatg tctggacata ctcagatacc   1080

cgctgtgatg caggctggct gccaaataat ggattttgct atctgctggt aaatgaaagt   1140

aattcctggg ataaggcaca tgcgaaatgc aaagccttca gtagtgacct aatcagcatt   1200

cattctctag cagatgtgga ggtggttgtc acaaaactcc ataatgagga tatcaaagaa   1260

gaagtgtgga taggccttaa gaacataaac ataccaactt tatttcagtg gtcagatggt   1320

actgaagtta ctctaacata ttgggatgag aatgagccaa atgttcccta caataagacg   1380

cccaactgtg tttcctactt aggagagcta ggtcagtgga aagtccaatc atgtgaggag   1440

aaactaaaat atgtatgcaa gagaaaggga gaaaaactga atgacgcaag ttctgataag   1500

atgtgtcctc cagatgaggg ctggaagaga catggagaaa cctgttacaa gatttatgag   1560

gatgaggtcc cttttggaac aaactgcaat ctgactatca ctagcagatt tgagcaagaa   1620

tacctaaatg atttgatgaa aaagtatgat aaatctctaa gaaaatactt ctggactggc   1680

ctgagagatg tagattcttg tggagagtat aactgggcaa ctgttggtgg aagaaggcgg   1740

gctgtaacct tttccaactg gaattttctt gagccagctt ccccgggcgg ctgcgtggct   1800

atgtctactg gaaagtctgt tggaaagtgg gaggtgaagg actgcagaag cttcaaagca   1860

ctttcaattt gcaagaaaat gagtggaccc cttgggcctg aagaagcatc ccctaagcct   1920

gatgacccct gtcctgaagg ctggcagagt ttccccgcaa gtctttcttg ttataaggta   1980

ttccatgcag aaagaattgt aagaaagagg aactgggaag aagctgaacg attctgccaa   2040

gcccttggag cacacctttc tagcttcagc catgtggatg aaataaagga atttcttcac   2100

tttttaacgg accagttcag tggccagcat tggctgtgga ttggtttgaa taaaaggagc   2160

ccagatttac aaggatcctg gcaatggagt gatcgtacac cagtgtctac tattatcatg   2220

ccaaatgagt ttcagcagga ttatgacatc agagactgtg ctgctgtcaa ggtatttcat   2280

aggccatggc gaagaggctg gcatttctat gatgatagag aatttattta tttgaggcct   2340

tttgcttgtg atacaaaact tgaatgggtg tgccaaattc caaaaggccg tactccaaaa   2400

acaccagact ggtacaatcc agaccgtgct ggaattcatg gacctccact tataattgaa   2460

ggaagtgaat attggtttgt tgctgatctt cacctaaact atgaagaagc cgtcctgtac   2520

tgtgccagca atcacagctt tcttgcaact ataacatctt ttgtgggact aaaagccatc   2580

aaaaacaaaa tagcaaatat atctggtgat ggacagaagt ggtggataag aattagcgag   2640

tggccaatag atgatcattt tacatactca cgatatccat ggcaccgctt tcctgtgaca   2700

tttggagagg aatgcttgta catgtctgcc aagacttggc ttatcgactt aggtaaacca   2760

acagactgta gtaccaagtt gcccttcatc tgtgaaaaat ataatgtttc ttcgttagag   2820

aaatacagcc cagattctgc agctaaagtg caatgttctg agcaatggat tccttttcag   2880

aataagtgtt ttctaaagat caaacccgtg tctctcacat tttctcaagc aagcgatacc   2940

tgtcactcct atggtggcac ccttccttca gtgttgagcc agattgaaca agactttatt   3000

acatccttgc ttccggatat ggaagctact ttatggattg gtttgcgctg gactgcctat   3060

gaaaagataa acaaatggac agataacaga gagctgacgt acagtaactt tcacccatta   3120

ttggttagtg ggaggctgag aataccagaa aatttttttg aggaagagtc tcgctaccac   3180

tgtgccctaa tactcaacct ccaaaaatca ccgtttactg ggacgtggaa ttttacatcc   3240

tgcagtgaac gccactttgt gtctctctgt cagaaatatt cagaagttaa aagcagacag   3300

acgttgcaga atgcttcaga aactgtaaag tatctaaata atctgtacaa aataatccca   3360

aagactctga cttggcacag tgctaaaagg gagtgtctga aaagtaacat gcagctggtg   3420

agcatcacgg acccttacca gcaggcattc ctcagtgtgc aggcgctcct tcacaactct   3480

tccttatgga tcggactctt cagtcaagat gatgaactca actttggttg gtcagatggg   3540

aaacgtcttc attttagtcg ctgggctgaa actaatgggc aactcgaaga ctgtgtagta   3600

ttagacactg atggattctg gaaaacagtt gattgcaatg acaatcaacc aggtgctatt   3660

tgctactatt caggaaatga gactgaaaaa gaggtcaaac cagttgacag tgttaaatgt   3720

ccatctcctg ttctaaatac tccgtggata ccatttcaga actgttgcta caatttcata   3780

ataacaaaga ataggcatat ggcaacaaca caggatgaag ttcatactaa atgccagaaa   3840

ctgaatccaa aatcacatat tctgagtatt cgagatgaaa aggagaataa ctttgttctt   3900

gagcaactgc tgtacttcaa ttatatggct tcatgggtca tgttaggaat aacttataga   3960

aataagtctc ttatgtggtt tgataagacc ccactgtcat atacacattg gagagcagga   4020

agaccaacta taaaaaatga gaagtttttg gctggtttaa gtactgacgg cttctgggat   4080

attcaaacct ttaaagttat tgaagaagca gtttattttc accagcacag cattcttgct   4140

tgtaaaattg aaatggttga ctacaaagaa gaatataata ctacactgcc acagtttatg   4200

ccatatgaag atggtattta cagtgttatt caaaaaaagg taacatggta tgaagcatta   4260

aacatgtgtt ctcaaagtgg aggtcacttg gcaagcgttc acaaccaaaa tggccagctc   4320

tttctggaag atattgtaaa acgtgatgga tttccactat gggttgggct ctcaagtcat   4380

gatggaagtg aatcaagttt tgaatggtct gatggtagta catttgacta tatcccatgg   4440

aaaggccaaa catctcctgg aaattgtgtt ctcttggatc caaaaggaac ttggaaacat   4500

gaaaaatgca actctgttaa ggatggtgct atttgttata aacctacaaa atctaaaaag   4560

ctgtcccgtc ttacatattc atcaagatgt ccagcagcaa aagagaatgg gtcacggtgg   4620

atccagtaca agggtcactg ttacaagtct gatcaggcat tgcacagttt ttcagaggcc   4680

aaaaaattgt gttcaaaaca tgatcactct gcaactatcg tttccataaa agatgaagat   4740

gagaataaat ttgtgagcag actgatgagg gaaaataata acattaccat gagagtttgg   4800

cttggattat ctcaacattc tgttgaccag tcttggagtt ggttagatgg atcagaagtg   4860

acatttgtca aatgggaaaa taaaagtaag agtggtgttg gaagatgtag catgttgata   4920

gcttcaaatg aaacttggaa aaaagttgaa tgtgaacatg gttttggaag agttgtctgc   4980

aaagtgcctc tggactgtcc ttcatctact tggattcagt tccaagacag ttgttacatt   5040

tttctccaag aagccatcaa agtagaaagc atagaggatg tcagaaatca gtgtactgac   5100

catggagcgg acatgataag catacataat gaagaagaaa atgcttttat actggatact   5160

ttgaaaaagc aatggaaagg cccagatgat atcctactag gcatgtttta tgacacagat   5220

gatgcgagtt tcaagtggtt tgataattca aatatgacat ttgataagtg gacagaccaa   5280

gatgatgatg aggatttagt tgacacctgt gcttttctgc acatcaagac aggtgaatgg   5340

aaaaaaggaa attgtgaagt ttcttctgtg gaaggaacac tatgcaaaac agctatccca   5400

tacaaaagga aatatttatc agataaccac attttaatat cagcattggt gattgctagc   5460

acggtaattt tgacagtttt gggagcaatc atttggttcc tgtacaaaaa acattctgat   5520

tctcgtttca ccacagtttt ttcaaccgca ccccaatcac cttataatga agactgtgtt   5580

ttggtagttg gagaagaaaa tgaatatcct gttcaatttg actaagtttt tggtaatctt   5640

gcactaagac atcaacaaaa tgccctggca gagataactt gggaaagatt ttaatataaa   5700

acttgacatt ggatattaga gctttaatgg tattccttat tccagtaaca tttttatgta   5760

ctcatctgct gtgaaaagtc tttaggttca ttaaaaaaac aggttttaga aatgatctta   5820

gatctaatat agtgatttta agcatcccgt caaaggcaga atctgtcact tgaatgaagg   5880

aaagcttaaa gcccaagcag ataaaaataa aagcccagcc tatttgtctt gcctgctgta   5940

tcttccctat ttagttgacc cactttagtt tatatgttta ttagtaaaca tgaaatgggg   6000

aataagtgat tttaagtaca tcccatacat ttaaatatct ttgataattg ttattttttt   6060

ggcagataat tcctctagaa tgtgtatctt tttatgattt agatgaagaa aattttacaa   6120

cttttaacac cccacaccaa ttttagtttc attactttta cacacaccat tttatcacaa   6180

atgactcaag ttttaatgaa tgtttataaa ttatttgaaa caaaatatga tcgctgtgtc   6240

caggatggca tagagaaagc tggcaattag gttaacactt acatattata gtgccccttt   6300

aaggatttct ctcttgccac catacctttt gtactttccc ctatacaaga tgtatctcat   6360

tctcctcaag catttataaa tttttccttc aatgacatga aaactgtgca agcaaaaacc   6420

gaagaaaaac acttaagtac aactgtagtg acagtgatca aagttttcag tgcatttatt   6480

gtacatttta agaaaaaggt gaaaatcatt tggggagtaa aaaaatgaaa aagctgaaac   6540

gagtaatttt cctcaccatc aataaaccaa aaacaggaaa gataaagaat gtataaattt   6600

cacgtaaatt agtcacgtat cacttatcaa tggggatacg ttctaagaaa tgcatagtta   6660

gggaatcttg tgtgaaaatc agcttgtatt tacacaaacc cagatggtag agcctatttt   6720

gtcccaaacc tacacagcat gttactgtgc tgaatactgc agacaattgt aacacaatat   6780

ttgtgtatct aaatatagaa aaggtacagt aaaaatatgg tctactaagg aaacactgtt   6840

ctatatgtgg tccattactg actgaagtat actgtctaga agtctgaggc tcaaagaaaa   6900

gtaatccctc ttctgaatcc acaccccatc aattatctta ctttcttctg gggagataga   6960

tagatatact atctcactag cttgactaat ggcaacaaag ttccagcttg tgtagtctct   7020

ttttattgac cacatgaatc gaaaacactc atcacaatta atggcactat cattaatgag   7080

acatgagtaa ctaaaaagtg atagaaaact attaacagtg cggctacatg gtactgaaaa   7140

tgcaggcatt acaccagctg ttacacaagc acaagcatgc tctgtaagag ctttacattt   7200

ctgagatttt gtatagtgat tgagatgtct attttattat tgatagacta ttactaatgt   7260

caatattgaa cactaccctg gaattcctgc ctggttttcc tacccaaatt gtaccactcc   7320

ttgaagaact acaggcacag taaaaaaaat atggcgtatt atgtgaacta aaagagttct   7380

aaaggagttc ttaaaggagt ggtagaattt gggtaggaaa gtgattaagt ccaacttaaa   7440

accaacagtc tcaaacgtct acaactacaa tgtccaatga gccactagcc acatgaggct   7500

atttaagtaa atttagttta aaatccagtt ttcgaattac attagccaca ttgtcaagtg   7560

ttcaaatcac aggtggttag tggctactgt actgggcaac atacattata gaacattttc   7620

attataggaa gttttattgg gcagtgctgc tcttaaatcc taccttccac tcaactccca   7680

tacaactttc ttttgtacat tttgatactt tctacctaat ggcagctctt ccaaaatagc   7740

tgctttaaac tctgatttaa ttttcaatat ttggtttcat ttttcaacag gccaagaggc   7800

ctctggtaat gaagtgctat atatatatat atgatggagt ctcactgtgc tgcccaggct   7860

acagtgcagt ggctcgatct tggctctctc caatctccgc cttgcaggtt ttcaagcaat   7920

tctcctgcct cagcctcctt agtagctggg accacagaca tctgtcacca cacccagcta   7980

actttttgta tttttggtag agacggggtt tcgccatatt gactgggctg gtctcaaact   8040

cctgacctca agtgatccac ccaccttggt ctcccaaagt gctgggatta catgcgtgag   8100

ccaccacact tggcctacat tttttcttta tataccagaa catctataac aggcacctta   8160

tctactcatt agtgaagaga taattggatt ac                                 8192


<210>  8613
<211>  1873
<212>  PRT
<213>  Homosapiens

<400>  8613

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Gln Ser  Trp Ser Trp Leu Asp  Gly Ser Glu Val Thr  Phe Val Lys 
    1610                 1615                 1620             


Trp Glu  Asn Lys Ser Lys Ser  Gly Val Gly Arg Cys  Ser Met Leu 
    1625                 1630                 1635             


Ile Ala  Ser Asn Glu Thr Trp  Lys Lys Val Glu Cys  Glu His Gly 
    1640                 1645                 1650             


Phe Gly  Arg Val Val Cys Lys  Val Pro Leu Asp Cys  Pro Ser Ser 
    1655                 1660                 1665             


Thr Trp  Ile Gln Phe Gln Asp  Ser Cys Tyr Ile Phe  Leu Gln Glu 
    1670                 1675                 1680             


Ala Ile  Lys Val Glu Ser Ile  Glu Asp Val Arg Asn  Gln Cys Thr 
    1685                 1690                 1695             


Asp His  Gly Ala Asp Met Ile  Ser Ile His Asn Glu  Glu Glu Asn 
    1700                 1705                 1710             


Ala Phe  Ile Leu Asp Thr Leu  Lys Lys Gln Trp Lys  Gly Pro Asp 
    1715                 1720                 1725             


Asp Ile  Leu Leu Gly Met Phe  Tyr Asp Thr Asp Asp  Ala Ser Phe 
    1730                 1735                 1740             


Lys Trp  Phe Asp Asn Ser Asn  Met Thr Phe Asp Lys  Trp Thr Asp 
    1745                 1750                 1755             


Gln Asp  Asp Asp Glu Asp Leu  Val Asp Thr Cys Ala  Phe Leu His 
    1760                 1765                 1770             


Ile Lys  Thr Gly Glu Trp Lys  Lys Gly Asn Cys Glu  Val Ser Ser 
    1775                 1780                 1785             


Val Glu  Gly Thr Leu Cys Lys  Thr Ala Ile Pro Tyr  Lys Arg Lys 
    1790                 1795                 1800             


Tyr Leu  Ser Asp Asn His Ile  Leu Ile Ser Ala Leu  Val Ile Ala 
    1805                 1810                 1815             


Ser Thr  Val Ile Leu Thr Val  Leu Gly Ala Ile Ile  Trp Phe Leu 
    1820                 1825                 1830             


Tyr Lys  Lys His Ser Asp Ser  Arg Phe Thr Thr Val  Phe Ser Thr 
    1835                 1840                 1845             


Ala Pro  Gln Ser Pro Tyr Asn  Glu Asp Cys Val Leu  Val Val Gly 
    1850                 1855                 1860             


Glu Glu  Asn Glu Tyr Pro Val  Gln Phe Asp 
    1865                 1870             


<210>  8614
<211>  3741
<212>  DNA
<213>  Homosapiens

<400>  8614
ctctccggcc gcgcagccgc tgccgcccac ccgcacccgc cgtcatgctc cgggccgcgc     60

tgcccgcgct cctgctgccg ttgctgggcc tcgccgctgc tgccgtcgcg gactgtcctt    120

catctacttg gattcagttc caagacagtt gttacatttt tctccaagaa gccatcaaag    180

tagaaagcat agaggatgtc agaaatcagt gtactgacca tggagcggac atgataagca    240

tacataatga agaagaaaat gcttttatac tggatacttt gaaaaagcaa tggaaaggcc    300

cagatgatat cctactaggc atgttttatg acacagatga tgcgagtttc aagtggtttg    360

ataattcaaa tatgacattt gataagtgga cagaccaaga tgatgatgag gatttagttg    420

acacctgtgc ttttctgcac atcaagacag gtgaatggaa aaaaggaaat tgtgaagttt    480

cttctgtgga aggaacacta tgcaaaacag ctatcccata caaaaggaaa tatttatcag    540

ataaccacat tttaatatca gcattggtga ttgctagcac ggtaattttg acagttttgg    600

gagcaatcat ttggttcctg tacaaaaaac attctgattc tcgtttcacc acagtttttt    660

caaccgcacc ccaatcacct tataatgaag actgtgtttt ggtagttgga gaagaaaatg    720

aatatcctgt tcaatttgac taagtttttg gtaatcttgc actaagacat caacaaaatg    780

ccctggcaga gataacttgg gaaagatttt aatataaaac ttgacattgg atattagagc    840

tttaatggta ttccttattc cagtaacatt tttatgtact catctgctgt gaaaagtctt    900

taggttcatt aaaaaaacag gttttagaaa tgatcttaga tctaatatag tgattttaag    960

catcccgtca aaggcagaat ctgtcacttg aatgaaggaa agcttaaagc ccaagcagat   1020

aaaaataaaa gcccagccta tttgtcttgc ctgctgtatc ttccctattt agttgaccca   1080

ctttagttta tatgtttatt agtaaacatg aaatggggaa taagtgattt taagtacatc   1140

ccatacattt aaatatcttt gataattgtt atttttttgg cagataattc ctctagaatg   1200

tgtatctttt tatgatttag atgaagaaaa ttttacaact tttaacaccc cacaccaatt   1260

ttagtttcat tacttttaca cacaccattt tatcacaaat gactcaagtt ttaatgaatg   1320

tttataaatt atttgaaaca aaatatgatc gctgtgtcca ggatggcata gagaaagctg   1380

gcaattaggt taacacttac atattatagt gcccctttaa ggatttctct cttgccacca   1440

taccttttgt actttcccct atacaagatg tatctcattc tcctcaagca tttataaatt   1500

tttccttcaa tgacatgaaa actgtgcaag caaaaaccga agaaaaacac ttaagtacaa   1560

ctgtagtgac agtgatcaaa gttttcagtg catttattgt acattttaag aaaaaggtga   1620

aaatcatttg gggagtaaaa aaatgaaaaa gctgaaacga gtaattttcc tcaccatcaa   1680

taaaccaaaa acaggaaaga taaagaatgt ataaatttca cgtaaattag tcacgtatca   1740

cttatcaatg gggatacgtt ctaagaaatg catagttagg gaatcttgtg tgaaaatcag   1800

cttgtattta cacaaaccca gatggtagag cctattttgt cccaaaccta cacagcatgt   1860

tactgtgctg aatactgcag acaattgtaa cacaatattt gtgtatctaa atatagaaaa   1920

ggtacagtaa aaatatggtc tactaaggaa acactgttct atatgtggtc cattactgac   1980

tgaagtatac tgtctagaag tctgaggctc aaagaaaagt aatccctctt ctgaatccac   2040

accccatcaa ttatcttact ttcttctggg gagatagata gatatactat ctcactagct   2100

tgactaatgg caacaaagtt ccagcttgtg tagtctcttt ttattgacca catgaatcga   2160

aaacactcat cacaattaat ggcactatca ttaatgagac atgagtaact aaaaagtgat   2220

agaaaactat taacagtgcg gctacatggt actgaaaatg caggcattac accagctgtt   2280

acacaagcac aagcatgctc tgtaagagct ttacatttct gagattttgt atagtgattg   2340

agatgtctat tttattattg atagactatt actaatgtca atattgaaca ctaccctgga   2400

attcctgcct ggttttccta cccaaattgt accactcctt gaagaactac aggcacagta   2460

aaaaaaatat ggcgtattat gtgaactaaa agagttctaa aggagttctt aaaggagtgg   2520

tagaatttgg gtaggaaagt gattaagtcc aacttaaaac caacagtctc aaacgtctac   2580

aactacaatg tccaatgagc cactagccac atgaggctat ttaagtaaat ttagtttaaa   2640

atccagtttt cgaattacat tagccacatt gtcaagtgtt caaatcacag gtggttagtg   2700

gctactgtac tgggcaacat acattataga acattttcat tataggaagt tttattgggc   2760

agtgctgctc ttaaatccta ccttccactc aactcccata caactttctt ttgtacattt   2820

tgatactttc tacctaatgg cagctcttcc aaaatagctg ctttaaactc tgatttaatt   2880

ttcaatattt ggtttcattt ttcaacaggc caagaggcct ctggtaatga agtgctatat   2940

atatatatat gatggagtct cactgtgctg cccaggctac agtgcagtgg ctcgatcttg   3000

gctctctcca atctccgcct tgcaggtttt caagcaattc tcctgcctca gcctccttag   3060

tagctgggac cacagacatc tgtcaccaca cccagctaac tttttgtatt tttggtagag   3120

acggggtttc gccatattga ctgggctggt ctcaaactcc tgacctcaag tgatccaccc   3180

accttggtct cccaaagtgc tgggattaca tgcgtgagcc accacacttg gcctacattt   3240

tttctttata taccagaaca tctataacag gcaccttatc tactcattag tgaagagata   3300

attggattac acaggcaggc ttgtttacta catccagaat gtagaaactg ctttcttcaa   3360

catcttggtt ctagctagta ataacaatat aattctttgg cagatattca gaataacatt   3420

ttaaactaca ttttcttaga aaattgcatt cttgtagtga gcagtgtatg gtctcttttg   3480

ttcagaattt aaaactgata accaatgaaa gccttttctc ttattcctct accgtcattt   3540

acatgataat ctgaagctaa tatgacaata tttaaatact aagtggtact agggaactac   3600

aagaatactg taaagcttaa gccattgtta tcactgtcat ttagcattta ataacaaaac   3660

tatacagaat tatgtgcata ccaatgaatg ttttgtacca tctagttaaa ttttttaaat   3720

aaagttttat gggttaagca g                                             3741


<210>  8615
<211>  232
<212>  PRT
<213>  Homosapiens

<400>  8615

Met Leu Arg Ala Ala Leu Pro Ala Leu Leu Leu Pro Leu Leu Gly Leu 
1               5                   10                  15      


Ala Ala Ala Ala Val Ala Asp Cys Pro Ser Ser Thr Trp Ile Gln Phe 
            20                  25                  30          


Gln Asp Ser Cys Tyr Ile Phe Leu Gln Glu Ala Ile Lys Val Glu Ser 
        35                  40                  45              


Ile Glu Asp Val Arg Asn Gln Cys Thr Asp His Gly Ala Asp Met Ile 
    50                  55                  60                  


Ser Ile His Asn Glu Glu Glu Asn Ala Phe Ile Leu Asp Thr Leu Lys 
65                  70                  75                  80  


Lys Gln Trp Lys Gly Pro Asp Asp Ile Leu Leu Gly Met Phe Tyr Asp 
                85                  90                  95      


Thr Asp Asp Ala Ser Phe Lys Trp Phe Asp Asn Ser Asn Met Thr Phe 
            100                 105                 110         


Asp Lys Trp Thr Asp Gln Asp Asp Asp Glu Asp Leu Val Asp Thr Cys 
        115                 120                 125             


Ala Phe Leu His Ile Lys Thr Gly Glu Trp Lys Lys Gly Asn Cys Glu 
    130                 135                 140                 


Val Ser Ser Val Glu Gly Thr Leu Cys Lys Thr Ala Ile Pro Tyr Lys 
145                 150                 155                 160 


Arg Lys Tyr Leu Ser Asp Asn His Ile Leu Ile Ser Ala Leu Val Ile 
                165                 170                 175     


Ala Ser Thr Val Ile Leu Thr Val Leu Gly Ala Ile Ile Trp Phe Leu 
            180                 185                 190         


Tyr Lys Lys His Ser Asp Ser Arg Phe Thr Thr Val Phe Ser Thr Ala 
        195                 200                 205             


Pro Gln Ser Pro Tyr Asn Glu Asp Cys Val Leu Val Val Gly Glu Glu 
    210                 215                 220                 


Asn Glu Tyr Pro Val Gln Phe Asp 
225                 230         


<210>  8616
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  8616
aggatgagga caggctgggc gacccctcgc cgcccggcgg ggctcctcat gctgctcttc     60

tggttcttcg atctcgcgga gccctctggc cgcgcagcta atgacccctt caccatcgtc    120

catggaaata cgggcaagtg catcaagcca gtgtatggct ggatagtagc agacgactgt    180

gatgaaactg aggacaagtt atggaagtgg gtgtcccagc atcggctctt tcatttgcac    240

tcccaaaagt gccttggcct cgatattacc aaatcggtaa atgagctgag aatgttcagc    300

tgtgactcca gtgccatgct gtggtggaaa tgtgagcacc actctctgta cggagctgcc    360

cggtaccggc tggctctgaa ggatggacat ggcacagcaa tctcaaatgc atctgatgtc    420

tggaagaaag gaggctcaga ggaaagcctt tgtgaccagc cttatcatga gatctatacc    480

agagatggga actcttatgg gagaccttgt gaatttccat tcttaattga tgggacctgg    540

catcatgatt gcattcttga tgaagatcat agtgggccat ggtgtgccac caccttaaat    600

tatgaatatg accgaaagtg gggcatctgc ttaaagcctg aaaacggttg tgaagataat    660

tgggaaaaga acgagcagtt tggaagttgc taccaattta atactcagac ggctctttct    720

tggaaagaag cttatgtttc atgtcagaat caaggagctg atttactgag catcaacagt    780

gctgctgaat taacttacct taaagaaaaa gaaggcattg ctaagatttt ctggattggt    840

ttaaatcagc tatactctgc tagaggctgg gaatggtcag accacaaacc attaaacttt    900

ctcaactggg atccagacag gcccagtgca cctactatag gtggctccag ctgtgcaaga    960

atggatgctg agtctggtct gtggcagagc ttttcctgtg aagctcaact gccctatgtc   1020

tgcaggaaac cattaaataa tacagtggag ttaacagatg tctggacata ctcagatacc   1080

cgctgtgatg caggctggct gccaaataat ggattttgct atctgctggt aaatgaaagt   1140

aattcctggg ataaggcaca tgcgaaatgc aaagccttca gtagtgacct aatcagcatt   1200

cattctctag cagatgtgga ggtggttgtc acaaaactcc ataatgagga tatcaaagaa   1260

gaagtgtgga taggccttaa gaacataaac ataccaactt tatttcagtg gtcagatggt   1320

actgaagtta ctctaacata ttgggatgag aatgagccaa atgttcccta caataagacg   1380

cccaactgtg tttcctactt aggagagcta ggtcagtgga aagtccaatc atgtgaggag   1440

aaactaaaat atgtatgcaa gagaaaggga gaaaaactga atgacgcaag ttctgataag   1500

atgtgtcctc cagatgaggg ctggaagaga catggagaaa cctgttacaa gatttatgag   1560

gatgaggtcc cttttggaac aaactgcaat ctgactatca ctagcagatt tgagcaagaa   1620

tacctaaatg atttgatgaa aaagtatgat aaatctctaa gaaaatactt ctggactggc   1680

ctgagagatg tagattcttg tggagagtat aactgggcaa ctgttggtgg aagaaggcgg   1740

gctgtaacct tttccaactg gaattttctt gagccagctt ccccgggcgg ctgcgtggct   1800

atgtctactg gaaagtctgt tggaaagtgg gaggtgaagg actgcagaag cttcaaagca   1860

ctttcaattt gcaagaaaat gagtggaccc cttgggcctg aagaagcatc ccctaagcct   1920

gatgacccct gtcctgaagg ctggcagagt ttccccgcaa gtctttcttg ttataaggta   1980

ttccatgcag aaagaattgt aagaaagagg aactgggaag aagctgaacg attctgccaa   2040

gcccttggag cacacctttc tagcttcagc catgtggatg aaataaagga atttcttcac   2100

tttttaacgg accagttcag tggccagcat tggctgtgga ttggtttgaa taaaaggagc   2160

ccagatttac aaggatcctg gcaatggagt gatcgtacac cagtgtctac tattatcatg   2220

ccaaatgagt ttcagcagga ttatgacatc agagactgtg ctgctgtcaa ggtatttcat   2280

aggccatggc gaagaggctg gcatttctat gatgatagag aatttattta tttgaggcct   2340

tttgcttgtg atacaaaact tgaatgggtg tgccaaattc caaaaggccg tactccaaaa   2400

acaccagact ggtacaatcc agaccgtgct ggaattcatg gacctccact tataattgaa   2460

ggaagtgaat attggtttgt tgctgatctt cacctaaact atgaagaagc cgtcctgtac   2520

tgtgccagca atcacagctt tcttgcaact ataacatctt ttgtgggact aaaagccatc   2580

aaaaacaaaa tagcaaatat atctggtgat ggacagaagt ggtggataag aattagcgag   2640

tggccaatag atgatcattt tacatactca cgatatccat ggcaccgctt tcctgtgaca   2700

tttggagagg aatgcttgta catgtctgcc aagacttggc ttatcgactt aggtaaacca   2760

acagactgta gtaccaagtt gcccttcatc tgtgaaaaat ataatgtttc ttcgttagag   2820

aaatacagcc cagattctgc agctaaagtg caatgttctg agcaatggat tccttttcag   2880

aataagtgtt ttctaaagat caaacccgtg tctctcacat tttctcaagc aagcgatacc   2940

tgtcactcct atggtggcac ccttccttca gtgttgagcc agattgaaca agactttatt   3000

acatccttgc ttccggatat ggaagctact ttatggattg gtttgcgctg gactgcctat   3060

gaaaagataa acaaatggac agataacaga gagctgacgt acagtaactt tcacccatta   3120

ttggttagtg ggaggctgag aataccagaa aatttttttg aggaagagtc tcgctaccac   3180

tgtgccctaa tactcaacct ccaaaaatca ccgtttactg ggacgtggaa ttttacatcc   3240

tgcagtgaac gccactttgt gtctctctgt cagaaatatt cagaagttaa aagcagacag   3300

acgttgcaga atgcttcaga aactgtaaag tatctaaata atctgtacaa aataatccca   3360

aagactctga cttggcacag tgctaaaagg gagtgtctga aaagtaacat gcagctggtg   3420

agcatcacgg acccttacca gcaggcattc ctcagtgtgc aggcgctcct tcacaactct   3480

tccttatgga tcggactctt cagtcaagat gatgaactca actttggttg gtcagatggg   3540

aaacgtcttc attttagtcg ctgggctgaa actaatgggc aactcgaaga ctgtgtagta   3600

ttagacactg atggattctg gaaaacagtt gattgcaatg acaatcaacc aggtgctatt   3660

tgctactatt caggaaatga gactgaaaaa gaggtcaaac cagttgacag tgttaaatgt   3720

ccatctcctg ttctaaatac tccgtggata ccatttcaga actgttgcta caatttcata   3780

ataacaaaga ataggcatat ggcaacaaca caggatgaag ttcatactaa atgccagaaa   3840

ctgaatccaa aatcacatat tctgagtatt cgagatgaaa aggagaataa ctttgttctt   3900

gagcaactgc tgtacttcaa ttatatggct tcatgggtca tgttaggaat aacttataga   3960

aataagtctc ttatgtggtt tgataagacc ccactgtcat atacacattg gagagcagga   4020

agaccaacta taaaaaatga gaagtttttg gctggtttaa gtactgacgg cttctgggat   4080

attcaaacct ttaaagttat tgaagaagca gtttattttc accagcacag cattcttgct   4140

tgtaaaattg aaatggttga ctacaaagaa gaatataata ctacactgcc acagtttatg   4200

ccatatgaag atggtattta cagtgttatt caaaaaaagg taacatggta tgaagcatta   4260

aacatgtgtt ctcaaagtgg aggtcacttg gcaagcgttc acaaccaaaa tggccagctc   4320

tttctggaag atattgtaaa acgtgatgga tttccactat gggttgggct ctcaagtcat   4380

gatggaagtg aatcaagttt tgaatggtct gatggtagta catttgacta tatcccatgg   4440

aaaggccaaa catctcctgg aaattgtgtt ctcttggatc caaaaggaac ttggaaacat   4500

gaaaaatgca actctgttaa ggatggtgct atttgttata aacctacaaa atctaaaaag   4560

ctgtcccgtc ttacatattc atcaagatgt ccagcagcaa aagagaatgg gtcacggtgg   4620

atccagtaca agggtcactg ttacaagtct gatcaggcat tgcacagttt ttcagaggcc   4680

aaaaaattgt gttcaaaaca tgatcactct gcaactatcg tttccataaa agatgaagat   4740

gagaataaat ttgtgagcag actgatgagg gaaaataata acattaccat gagagtttgg   4800

cttggattat ctcaacattc tgttgactgt ccttcatcta cttggattca gttccaagac   4860

agttgttaca tttttctcca agaagccatc aaagtagaaa gcatagagga tgtcagaaat   4920

cagtgtactg accatggagc ggacatgata agcatacata atgaagaaga aaatgctttt   4980

atactggata ctttgaaaaa gcaatggaaa ggcccagatg atatcctact aggcatgttt   5040

tatgacacag atgatgcgag tttcaagtgg tttgataatt caaatatgac atttgataag   5100

tggacagacc aagatgatga tgaggattta gttgacacct gtgcttttct gcacatcaag   5160

acaggtgaat ggaaaaaagg aaattgtgaa gtttcttctg tggaaggaac actatgcaaa   5220

acagctatcc catacaaaag gaaatattta tcagataacc acattttaat atcagcattg   5280

gtgattgcta gcacggtaat tttgacagtt ttgggagcaa tcatttggtt cctgtacaaa   5340

aaacattctg attctcgttt caccacagtt ttttcaaccg caccccaatc accttataat   5400

gaagactgtg ttttggtagt tggagaagaa aatgaatatc ctgttcaatt tgactaagtt   5460

tttggtaatc ttgcactaag acatcaacaa aatgccctgg cagagataac ttgggaaaga   5520

ttttaatata aaacttgaca ttggatatta gagctttaat ggtattcctt attccagtaa   5580

catttttatg tactcatctg ctgtgaaaag tctttaggtt cattaaaaaa acaggtttta   5640

gaaatgatct tagatctaat atagtgattt taagcatccc gtcaaaggca gaatctgtca   5700

cttgaatgaa ggaaagctta aagcccaagc agataaaaat aaaagcccag cctatttgtc   5760

ttgcctgctg tatcttccct atttagttga cccactttag tttatatgtt tattagtaaa   5820

catgaaatgg ggaataagtg attttaagta catcccatac atttaaatat ctttgataat   5880

tgttattttt ttggcagata attcctctag aatgtgtatc tttttatgat ttagatgaag   5940

aaaattttac aacttttaac accccacacc aattttagtt tcattacttt tacacacacc   6000

attttatcac aaatgactca agttttaatg aatgtttata aattatttga aacaaaatat   6060

gatcgctgtg tccaggatgg catagagaaa gctggcaatt aggttaacac ttacatatta   6120

tagtgcccct ttaaggattt ctctcttgcc accatacctt ttgtactttc ccctatacaa   6180

gatgtatctc attctcctca agcatttata aatttttcct tcaatgacat gaaaactgtg   6240

caagcaaaaa ccgaagaaaa acacttaagt acaactgtag tgacagtgat caaagttttc   6300

agtgcattta ttgtacattt taagaaaaag gtgaaaatca tttggggagt aaaaaaatga   6360

aaaagctgaa acgagtaatt ttcctcacca tcaataaacc aaaaacagga aagataaaga   6420

atgtataaat ttcacgtaaa ttagtcacgt atcacttatc aatggggata cgttctaaga   6480

aatgcatagt tagggaatct tgtgtgaaaa tcagcttgta tttacacaaa cccagatggt   6540

agagcctatt ttgtcccaaa cctacacagc atgttactgt gctgaatact gcagacaatt   6600

gtaacacaat atttgtgtat ctaaatatag aaaaggtaca gtaaaaatat ggtctactaa   6660

ggaaacactg ttctatatgt ggtccattac tgactgaagt atactgtcta gaagtctgag   6720

gctcaaagaa aagtaatccc tcttctgaat ccacacccca tcaattatct tactttcttc   6780

tggggagata gatagatata ctatctcact agcttgacta atggcaacaa agttccagct   6840

tgtgtagtct ctttttattg accacatgaa tcgaaaacac tcatcacaat taatggcact   6900

atcattaatg agacatgagt aactaaaaag tgatagaaaa ctattaacag tgcggctaca   6960

tggtactgaa aatgcaggca ttacaccagc tgttacacaa gcacaagcat gctctgtaag   7020

agctttacat ttctgagatt ttgtatagtg attgagatgt ctattttatt attgatagac   7080

tattactaat gtcaatattg aacactaccc tggaattcct gcctggtttt cctacccaaa   7140

ttgtaccact ccttgaagaa ctacaggcac agtaaaaaaa atatggcgta ttatgtgaac   7200

taaaagagtt ctaaaggagt tcttaaagga gtggtagaat ttgggtagga aagtgattaa   7260

gtccaactta aaaccaacag tctcaaacgt ctacaactac aatgtccaat gagccactag   7320

ccacatgagg ctatttaagt aaatttagtt taaaatccag ttttcgaatt acattagcca   7380

cattgtcaag tgttcaaatc acaggtggtt agtggctact gtactgggca acatacatta   7440

tagaacattt tcattatagg aagttttatt gggcagtgct gctcttaaat cctaccttcc   7500

actcaactcc catacaactt tcttttgtac attttgatac tttctaccta atggcagctc   7560

ttccaaaata gctgctttaa actctgattt aattttcaat atttggtttc atttttcaac   7620

aggccaagag gcctctggta atgaagtgct atatatatat atatgatgga gtctcactgt   7680

gctgcccagg ctacagtgca gtggctcgat cttggctctc tccaatctcc gccttgcagg   7740

ttttcaagca attctcctgc ctcagcctcc ttagtagctg ggaccacaga catctgtcac   7800

cacacccagc taactttttg tatttttggt agagacgggg tttcgccata ttgactgggc   7860

tggtctcaaa ctcctgacct caagtgatcc acccaccttg gtctcccaaa gtgctgggat   7920

tacatgcgtg agccaccaca cttggcctac attttttctt tatataccag aacatctata   7980

acaggcacct tatctactca ttagtgaaga gataattgga ttacacaggc aggcttgttt   8040

actacatcca gaatgtagaa actgctttct tcaacatctt ggttctagct agtaataaca   8100

atataattct ttggcagata ttcagaataa cattttaaac tacattttct tagaaaattg   8160

cattcttgta gtgagcagtg tatggtctct tt                                 8192


<210>  8617
<211>  1817
<212>  PRT
<213>  Homosapiens

<400>  8617

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Cys Pro  Ser Ser Thr Trp Ile  Gln Phe Gln Asp Ser  Cys Tyr Ile 
    1610                 1615                 1620             


Phe Leu  Gln Glu Ala Ile Lys  Val Glu Ser Ile Glu  Asp Val Arg 
    1625                 1630                 1635             


Asn Gln  Cys Thr Asp His Gly  Ala Asp Met Ile Ser  Ile His Asn 
    1640                 1645                 1650             


Glu Glu  Glu Asn Ala Phe Ile  Leu Asp Thr Leu Lys  Lys Gln Trp 
    1655                 1660                 1665             


Lys Gly  Pro Asp Asp Ile Leu  Leu Gly Met Phe Tyr  Asp Thr Asp 
    1670                 1675                 1680             


Asp Ala  Ser Phe Lys Trp Phe  Asp Asn Ser Asn Met  Thr Phe Asp 
    1685                 1690                 1695             


Lys Trp  Thr Asp Gln Asp Asp  Asp Glu Asp Leu Val  Asp Thr Cys 
    1700                 1705                 1710             


Ala Phe  Leu His Ile Lys Thr  Gly Glu Trp Lys Lys  Gly Asn Cys 
    1715                 1720                 1725             


Glu Val  Ser Ser Val Glu Gly  Thr Leu Cys Lys Thr  Ala Ile Pro 
    1730                 1735                 1740             


Tyr Lys  Arg Lys Tyr Leu Ser  Asp Asn His Ile Leu  Ile Ser Ala 
    1745                 1750                 1755             


Leu Val  Ile Ala Ser Thr Val  Ile Leu Thr Val Leu  Gly Ala Ile 
    1760                 1765                 1770             


Ile Trp  Phe Leu Tyr Lys Lys  His Ser Asp Ser Arg  Phe Thr Thr 
    1775                 1780                 1785             


Val Phe  Ser Thr Ala Pro Gln  Ser Pro Tyr Asn Glu  Asp Cys Val 
    1790                 1795                 1800             


Leu Val  Val Gly Glu Glu Asn  Glu Tyr Pro Val Gln  Phe Asp 
    1805                 1810                 1815         


<210>  8618
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  8618
aggatgagga caggctgggc gacccctcgc cgcccggcgg ggctcctcat gctgctcttc     60

tggttcttcg atctcgcgga gccctctggc cgcgcagcta atgacccctt caccatcgtc    120

catggaaata cgggcaagtg catcaagcca gtgtatggct ggatagtagc agacgactgt    180

gatgaaactg aggacaagtt atggaagtgg gtgtcccagc atcggctctt tcatttgcac    240

tcccaaaagt gccttggcct cgatattacc aaatcggtaa atgagctgag aatgttcagc    300

tgtgactcca gtgccatgct gtggtggaaa tgtgagcacc actctctgta cggagctgcc    360

cggtaccggc tggctctgaa ggatggacat ggcacagcaa tctcaaatgc atctgatgtc    420

tggaagaaag gaggctcaga ggaaagcctt tgtgaccagc cttatcatga gatctatacc    480

agagatggga actcttatgg gagaccttgt gaatttccat tcttaattga tgggacctgg    540

catcatgatt gcattcttga tgaagatcat agtgggccat ggtgtgccac caccttaaat    600

tatgaatatg accgaaagtg gggcatctgc ttaaagcctg aaaacggttg tgaagataat    660

tgggaaaaga acgagcagtt tggaagttgc taccaattta atactcagac ggctctttct    720

tggaaagaag cttatgtttc atgtcagaat caaggagctg atttactgag catcaacagt    780

gctgctgaat taacttacct taaagaaaaa gaaggcattg ctaagatttt ctggattggt    840

ttaaatcagc tatactctgc tagaggctgg gaatggtcag accacaaacc attaaacttt    900

ctcaactggg atccagacag gcccagtgca cctactatag gtggctccag ctgtgcaaga    960

atggatgctg agtctggtct gtggcagagc ttttcctgtg aagctcaact gccctatgtc   1020

tgcaggaaac cattaaataa tacagtggag ttaacagatg tctggacata ctcagatacc   1080

cgctgtgatg caggctggct gccaaataat ggattttgct atctgctggt aaatgaaagt   1140

aattcctggg ataaggcaca tgcgaaatgc aaagccttca gtagtgacct aatcagcatt   1200

cattctctag cagatgtgga ggtggttgtc acaaaactcc ataatgagga tatcaaagaa   1260

gaagtgtgga taggccttaa gaacataaac ataccaactt tatttcagtg gtcagatggt   1320

actgaagtta ctctaacata ttgggatgag aatgagccaa atgttcccta caataagacg   1380

cccaactgtg tttcctactt aggagagcta ggtcagtgga aagtccaatc atgtgaggag   1440

aaactaaaat atgtatgcaa gagaaaggga gaaaaactga atgacgcaag ttctgataag   1500

atgtgtcctc cagatgaggg ctggaagaga catggagaaa cctgttacaa gatttatgag   1560

gatgaggtcc cttttggaac aaactgcaat ctgactatca ctagcagatt tgagcaagaa   1620

tacctaaatg atttgatgaa aaagtatgat aaatctctaa gaaaatactt ctggactggc   1680

ctgagagatg tagattcttg tggagagtat aactgggcaa ctgttggtgg aagaaggcgg   1740

gctgtaacct tttccaactg gaattttctt gagccagctt ccccgggcgg ctgcgtggct   1800

atgtctactg gaaagtctgt tggaaagtgg gaggtgaagg actgcagaag cttcaaagca   1860

ctttcaattt gcaagaaaat gagtggaccc cttgggcctg aagaagcatc ccctaagcct   1920

gatgacccct gtcctgaagg ctggcagagt ttccccgcaa gtctttcttg ttataaggta   1980

ttccatgcag aaagaattgt aagaaagagg aactgggaag aagctgaacg attctgccaa   2040

gcccttggag cacacctttc tagcttcagc catgtggatg aaataaagga atttcttcac   2100

tttttaacgg accagttcag tggccagcat tggctgtgga ttggtttgaa taaaaggagc   2160

ccagatttac aaggatcctg gcaatggagt gatcgtacac cagtgtctac tattatcatg   2220

ccaaatgagt ttcagcagga ttatgacatc agagactgtg ctgctgtcaa ggtatttcat   2280

aggccatggc gaagaggctg gcatttctat gatgatagag aatttattta tttgaggcct   2340

tttgcttgtg atacaaaact tgaatgggtg tgccaaattc caaaaggccg tactccaaaa   2400

acaccagact ggtacaatcc agaccgtgct ggaattcatg gacctccact tataattgaa   2460

ggaagtgaat attggtttgt tgctgatctt cacctaaact atgaagaagc cgtcctgtac   2520

tgtgccagca atcacagctt tcttgcaact ataacatctt ttgtgggact aaaagccatc   2580

aaaaacaaaa tagcaaatat atctggtgat ggacagaagt ggtggataag aattagcgag   2640

tggccaatag atgatcattt tacatactca cgatatccat ggcaccgctt tcctgtgaca   2700

tttggagagg aatgcttgta catgtctgcc aagacttggc ttatcgactt aggtaaacca   2760

acagactgta gtaccaagtt gcccttcatc tgtgaaaaat ataatgtttc ttcgttagag   2820

aaatacagcc cagattctgc agctaaagtg caatgttctg agcaatggat tccttttcag   2880

aataagtgtt ttctaaagat caaacccgtg tctctcacat tttctcaagc aagcgatacc   2940

tgtcactcct atggtggcac ccttccttca gtgttgagcc agattgaaca agactttatt   3000

acatccttgc ttccggatat ggaagctact ttatggattg gtttgcgctg gactgcctat   3060

gaaaagataa acaaatggac agataacaga gagctgacgt acagtaactt tcacccatta   3120

ttggttagtg ggaggctgag aataccagaa aatttttttg aggaagagtc tcgctaccac   3180

tgtgccctaa tactcaacct ccaaaaatca ccgtttactg ggacgtggaa ttttacatcc   3240

tgcagtgaac gccactttgt gtctctctgt cagaaatatt cagaagttaa aagcagacag   3300

acgttgcaga atgcttcaga aactgtaaag tatctaaata atctgtacaa aataatccca   3360

aagactctga cttggcacag tgctaaaagg gagtgtctga aaagtaacat gcagctggtg   3420

agcatcacgg acccttacca gcaggcattc ctcagtgtgc aggcgctcct tcacaactct   3480

tccttatgga tcggactctt cagtcaagat gatgaactca actttggttg gtcagatggg   3540

aaacgtcttc attttagtcg ctgggctgaa actaatgggc aactcgaaga ctgtgtagta   3600

ttagacactg atggattctg gaaaacagtt gattgcaatg acaatcaacc aggtgctatt   3660

tgctactatt caggaaatga gactgaaaaa gaggtcaaac cagttgacag tgttaaatgt   3720

ccatctcctg ttctaaatac tccgtggata ccatttcaga actgttgcta caatttcata   3780

ataacaaaga ataggcatat ggcaacaaca caggatgaag ttcatactaa atgccagaaa   3840

ctgaatccaa aatcacatat tctgagtatt cgagatgaaa aggagaataa ctttgttctt   3900

gagcaactgc tgtacttcaa ttatatggct tcatgggtca tgttaggaat aacttataga   3960

aataagtctc ttatgtggtt tgataagacc ccactgtcat atacacattg gagagcagga   4020

agaccaacta taaaaaatga gaagtttttg gctggtttaa gtactgacgg cttctgggat   4080

attcaaacct ttaaagttat tgaagaagca gtttattttc accagcacag cattcttgct   4140

tgtaaaattg aaatggttga ctacaaagaa gaatataata ctacactgcc acagtttatg   4200

ccatatgaag atggtattta cagtgttatt caaaaaaagg taacatggta tgaagcatta   4260

aacatgtgtt ctcaaagtgg aggtcacttg gcaagcgttc acaaccaaaa tggccagctc   4320

tttctggaag atattgtaaa acgtgatgga tttccactat gggttgggct ctcaagtcat   4380

gatggaagtg aatcaagttt tgaatggtct gatggtagta catttgacta tatcccatgg   4440

aaaggccaaa catctcctgg aaattgtgtt ctcttggatc caaaaggaac ttggaaacat   4500

gaaaaatgca actctgttaa ggatggtgct atttgttata aacctacaaa atctaaaaag   4560

ctgtcccgtc ttacatattc atcaagatgt ccagcagcaa aagagaatgg gtcacggtgg   4620

atccagtaca agggtcactg ttacaagtct gatcaggcat tgcacagttt ttcagaggcc   4680

aaaaaattgt gttcaaaaca tgatcactct gcaactatcg tttccataaa agatgaagat   4740

gagaataaat ttgtgagcag actgatgagg gaaaataata acattaccat gagagtttgg   4800

cttggattat ctcaacattc tgttgaccag tcttggagtt ggttagatgg atcagaagtg   4860

acatttgtca aatgggaaaa taaaagtaag agtggtgttg gaagatgtag catgttgata   4920

gcttcaaatg aaacttggaa aaaagttgaa tgtgaacatg gttttggaag agttgtctgc   4980

aaagtgcctc tggactgtcc ttcatctact tggattcagt tccaagacag ttgttacatt   5040

tttctccaag aagccatcaa agtagaaagc atagaggatg tcagaaatca gtgtactgac   5100

catggagcgg acatgataag catacataat gaagaagaaa atgcttttat actggatact   5160

ttgaaaaagc aatggaaagg cccagatgat atcctactag gcatgtttta tgacacagat   5220

gatgcgagtt tcaagtggtt tgataattca aatatgacat ttgataagtg gacagaccaa   5280

gatgatgatg aggatttagt tgacacctgt gcttttctgc acatcaagac aggtgaatgg   5340

aaaaaaggaa attgtgaagt ttcttctgtg gaaggaacac tatgcaaaac agctatccca   5400

tacaaaagga aatatttatc agataaccac attttaatat cagcattggt gattgctagc   5460

acggtaattt tgacagtttt gggagcaatc atttggttcc tgtacaaaaa acattctgat   5520

tctcgtttca ccacagtttt ttcaaccgca ccccaatcac cttataatga agactgtgtt   5580

ttggtagttg gagaagaaaa tgaatatcct gttcaatttg actaagtttt tggtaatctt   5640

gcactaagac atcaacaaaa tgccctggca gagataactt gggaaagatt ttaatataaa   5700

acttgacatt ggatattaga gctttaatgg tattccttat tccagtaaca tttttatgta   5760

ctcatctgct gtgaaaagtc tttaggttca ttaaaaaaac aggttttaga aatgatctta   5820

gatctaatat agtgatttta agcatcccgt caaaggcaga atctgtcact tgaatgaagg   5880

aaagcttaaa gcccaagcag ataaaaataa aagcccagcc tatttgtctt gcctgctgta   5940

tcttccctat ttagttgacc cactttagtt tatatgttta ttagtaaaca tgaaatgggg   6000

aataagtgat tttaagtaca tcccatacat ttaaatatct ttgataattg ttattttttt   6060

ggcagataat tcctctagaa tgtgtatctt tttatgattt agatgaagaa aattttacaa   6120

cttttaacac cccacaccaa ttttagtttc attactttta cacacaccat tttatcacaa   6180

atgactcaag ttttaatgaa tgtttataaa ttatttgaaa caaaatatga tcgctgtgtc   6240

caggatggca tagagaaagc tggcaattag gttaacactt acatattata gtgccccttt   6300

aaggatttct ctcttgccac catacctttt gtactttccc ctatacaaga tgtatctcat   6360

tctcctcaag catttataaa tttttccttc aatgacatga aaactgtgca agcaaaaacc   6420

gaagaaaaac acttaagtac aactgtagtg acagtgatca aagttttcag tgcatttatt   6480

gtacatttta agaaaaaggt gaaaatcatt tggggagtaa aaaaatgaaa aagctgaaac   6540

gagtaatttt cctcaccatc aataaaccaa aaacaggaaa gataaagaat gtataaattt   6600

cacgtaaatt agtcacgtat cacttatcaa tggggatacg ttctaagaaa tgcatagtta   6660

gggaatcttg tgtgaaaatc agcttgtatt tacacaaacc cagatggtag agcctatttt   6720

gtcccaaacc tacacagcat gttactgtgc tgaatactgc agacaattgt aacacaatat   6780

ttgtgtatct aaatatagaa aaggtacagt aaaaatatgg tctactaagg aaacactgtt   6840

ctatatgtgg tccattactg actgaagtat actgtctaga agtctgaggc tcaaagaaaa   6900

gtaatccctc ttctgaatcc acaccccatc aattatctta ctttcttctg gggagataga   6960

tagatatact atctcactag cttgactaat ggcaacaaag ttccagcttg tgtagtctct   7020

ttttattgac cacatgaatc gaaaacactc atcacaatta atggcactat cattaatgag   7080

acatgagtaa ctaaaaagtg atagaaaact attaacagtg cggctacatg gtactgaaaa   7140

tgcaggcatt acaccagctg ttacacaagc acaagcatgc tctgtaagag ctttacattt   7200

ctgagatttt gtatagtgat tgagatgtct attttattat tgatagacta ttactaatgt   7260

caatattgaa cactaccctg gaattcctgc ctggttttcc tacccaaatt gtaccactcc   7320

ttgaagaact acaggcacag taaaaaaaat atggcgtatt atgtgaacta aaagagttct   7380

aaaggagttc ttaaaggagt ggtagaattt gggtaggaaa gtgattaagt ccaacttaaa   7440

accaacagtc tcaaacgtct acaactacaa tgtccaatga gccactagcc acatgaggct   7500

atttaagtaa atttagttta aaatccagtt ttcgaattac attagccaca ttgtcaagtg   7560

ttcaaatcac aggtggttag tggctactgt actgggcaac atacattata gaacattttc   7620

attataggaa gttttattgg gcagtgctgc tcttaaatcc taccttccac tcaactccca   7680

tacaactttc ttttgtacat tttgatactt tctacctaat ggcagctctt ccaaaatagc   7740

tgctttaaac tctgatttaa ttttcaatat ttggtttcat ttttcaacag gccaagaggc   7800

ctctggtaat gaagtgctat atatatatat atgatggagt ctcactgtgc tgcccaggct   7860

acagtgcagt ggctcgatct tggctctctc caatctccgc cttgcaggtt ttcaagcaat   7920

tctcctgcct cagcctcctt agtagctggg accacagaca tctgtcacca cacccagcta   7980

actttttgta tttttggtag agacggggtt tcgccatatt gactgggctg gtctcaaact   8040

cctgacctca agtgatccac ccaccttggt ctcccaaagt gctgggatta catgcgtgag   8100

ccaccacact tggcctacat tttttcttta tataccagaa catctataac aggcacctta   8160

tctactcatt agtgaagaga taattggatt ac                                 8192


<210>  8619
<211>  1873
<212>  PRT
<213>  Homosapiens

<400>  8619

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Gln Ser  Trp Ser Trp Leu Asp  Gly Ser Glu Val Thr  Phe Val Lys 
    1610                 1615                 1620             


Trp Glu  Asn Lys Ser Lys Ser  Gly Val Gly Arg Cys  Ser Met Leu 
    1625                 1630                 1635             


Ile Ala  Ser Asn Glu Thr Trp  Lys Lys Val Glu Cys  Glu His Gly 
    1640                 1645                 1650             


Phe Gly  Arg Val Val Cys Lys  Val Pro Leu Asp Cys  Pro Ser Ser 
    1655                 1660                 1665             


Thr Trp  Ile Gln Phe Gln Asp  Ser Cys Tyr Ile Phe  Leu Gln Glu 
    1670                 1675                 1680             


Ala Ile  Lys Val Glu Ser Ile  Glu Asp Val Arg Asn  Gln Cys Thr 
    1685                 1690                 1695             


Asp His  Gly Ala Asp Met Ile  Ser Ile His Asn Glu  Glu Glu Asn 
    1700                 1705                 1710             


Ala Phe  Ile Leu Asp Thr Leu  Lys Lys Gln Trp Lys  Gly Pro Asp 
    1715                 1720                 1725             


Asp Ile  Leu Leu Gly Met Phe  Tyr Asp Thr Asp Asp  Ala Ser Phe 
    1730                 1735                 1740             


Lys Trp  Phe Asp Asn Ser Asn  Met Thr Phe Asp Lys  Trp Thr Asp 
    1745                 1750                 1755             


Gln Asp  Asp Asp Glu Asp Leu  Val Asp Thr Cys Ala  Phe Leu His 
    1760                 1765                 1770             


Ile Lys  Thr Gly Glu Trp Lys  Lys Gly Asn Cys Glu  Val Ser Ser 
    1775                 1780                 1785             


Val Glu  Gly Thr Leu Cys Lys  Thr Ala Ile Pro Tyr  Lys Arg Lys 
    1790                 1795                 1800             


Tyr Leu  Ser Asp Asn His Ile  Leu Ile Ser Ala Leu  Val Ile Ala 
    1805                 1810                 1815             


Ser Thr  Val Ile Leu Thr Val  Leu Gly Ala Ile Ile  Trp Phe Leu 
    1820                 1825                 1830             


Tyr Lys  Lys His Ser Asp Ser  Arg Phe Thr Thr Val  Phe Ser Thr 
    1835                 1840                 1845             


Ala Pro  Gln Ser Pro Tyr Asn  Glu Asp Cys Val Leu  Val Val Gly 
    1850                 1855                 1860             


Glu Glu  Asn Glu Tyr Pro Val  Gln Phe Asp 
    1865                 1870             


<210>  8620
<211>  5551
<212>  DNA
<213>  Homosapiens

<400>  8620
aggatgagga caggctgggc gacccctcgc cgcccggcgg ggctcctcat gctgctcttc     60

tggttcttcg atctcgcgga gccctctggc cgcgcagcta atgacccctt caccatcgtc    120

catggaaata cgggcaagtg catcaagcca gtgtatggct ggatagtagc agacgactgt    180

gatgaaactg aggacaagtt atggaagtgg gtgtcccagc atcggctctt tcatttgcac    240

tcccaaaagt gccttggcct cgatattacc aaatcggtaa atgagctgag aatgttcagc    300

tgtgactcca gtgccatgct gtggtggaaa tgtgagcacc actctctgta cggagctgcc    360

cggtaccggc tggctctgaa ggatggacat ggcacagcaa tctcaaatgc atctgatgtc    420

tggaagaaag gaggctcaga ggaaagcctt tgtgaccagc cttatcatga gatctatacc    480

agagatggga actcttatgg gagaccttgt gaatttccat tcttaattga tgggacctgg    540

catcatgatt gcattcttga tgaagatcat agtgggccat ggtgtgccac caccttaaat    600

tatgaatatg accgaaagtg gggcatctgc ttaaagcctg aaaacggttg tgaagataat    660

tgggaaaaga acgagcagtt tggaagttgc taccaattta atactcagac ggctctttct    720

tggaaagaag cttatgtttc atgtcagaat caaggagctg atttactgag catcaacagt    780

gctgctgaat taacttacct taaagaaaaa gaaggcattg ctaagatttt ctggattggt    840

ttaaatcagc tatactctgc tagaggctgg gaatggtcag accacaaacc attaaacttt    900

ctcaactggg atccagacag gcccagtgca cctactatag gtggctccag ctgtgcaaga    960

atggatgctg agtctggtct gtggcagagc ttttcctgtg aagctcaact gccctatgtc   1020

tgcaggaaac cattaaataa tacagtggag ttaacagatg tctggacata ctcagatacc   1080

cgctgtgatg caggctggct gccaaataat ggattttgct atctgctggt aaatgaaagt   1140

aattcctggg ataaggcaca tgcgaaatgc aaagccttca gtagtgacct aatcagcatt   1200

cattctctag cagatgtgga ggtggttgtc acaaaactcc ataatgagga tatcaaagaa   1260

gaagtgtgga taggccttaa gaacataaac ataccaactt tatttcagtg gtcagatggt   1320

actgaagtta ctctaacata ttgggatgag aatgagccaa atgttcccta caataagacg   1380

cccaactgtg tttcctactt aggagagcta ggtcagtgga aagtccaatc atgtgaggag   1440

aaactaaaat atgtatgcaa gagaaaggga gaaaaactga atgacgcaag ttctgataag   1500

atgtgtcctc cagatgaggg ctggaagaga catggagaaa cctgttacaa gatttatgag   1560

gatgaggtcc cttttggaac aaactgcaat ctgactatca ctagcagatt tgagcaagaa   1620

tacctaaatg atttgatgaa aaagtatgat aaatctctaa gaaaatactt ctggactggc   1680

ctgagagatg tagattcttg tggagagtat aactgggcaa ctgttggtgg aagaaggcgg   1740

gctgtaacct tttccaactg gaattttctt gagccagctt ccccgggcgg ctgcgtggct   1800

atgtctactg gaaagtctgt tggaaagtgg gaggtgaagg actgcagaag cttcaaagca   1860

ctttcaattt gcaagaaaat gagtggaccc cttgggcctg aagaagcatc ccctaagcct   1920

gatgacccct gtcctgaagg ctggcagagt ttccccgcaa gtctttcttg ttataaggta   1980

ttccatgcag aaagaattgt aagaaagagg aactgggaag aagctgaacg attctgccaa   2040

gcccttggag cacacctttc tagcttcagc catgtggatg aaataaagga atttcttcac   2100

tttttaacgg accagttcag tggccagcat tggctgtgga ttggtttgaa taaaaggagc   2160

ccagatttac aaggatcctg gcaatggagt gatcgtacac cagtgtctac tattatcatg   2220

ccaaatgagt ttcagcagga ttatgacatc agagactgtg ctgctgtcaa ggtatttcat   2280

aggccatggc gaagaggctg gcatttctat gatgatagag aatttattta tttgaggcct   2340

tttgcttgtg atacaaaact tgaatgggtg tgccaaattc caaaaggccg tactccaaaa   2400

acaccagact ggtacaatcc agaccgtgct ggaattcatg gacctccact tataattgaa   2460

ggaagtgaat attggtttgt tgctgatctt cacctaaact atgaagaagc cgtcctgtac   2520

tgtgccagca atcacagctt tcttgcaact ataacatctt ttgtgggact aaaagccatc   2580

aaaaacaaaa tagcaaatat atctggtgat ggacagaagt ggtggataag aattagcgag   2640

tggccaatag atgatcattt tacatactca cgatatccat ggcaccgctt tcctgtgaca   2700

tttggagagg aatgcttgta catgtctgcc aagacttggc ttatcgactt aggtaaacca   2760

acagactgta gtaccaagtt gcccttcatc tgtgaaaaat ataatgtttc ttcgttagag   2820

aaatacagcc cagattctgc agctaaagtg caatgttctg agcaatggat tccttttcag   2880

aataagtgtt ttctaaagat caaacccgtg tctctcacat tttctcaagc aagcgatacc   2940

tgtcactcct atggtggcac ccttccttca gtgttgagcc agattgaaca agactttatt   3000

acatccttgc ttccggatat ggaagctact ttatggattg gtttgcgctg gactgcctat   3060

gaaaagataa acaaatggac agataacaga gagctgacgt acagtaactt tcacccatta   3120

ttggttagtg ggaggctgag aataccagaa aatttttttg aggaagagtc tcgctaccac   3180

tgtgccctaa tactcaacct ccaaaaatca ccgtttactg ggacgtggaa ttttacatcc   3240

tgcagtgaac gccactttgt gtctctctgt cagaaatatt cagaagttaa aagcagacag   3300

acgttgcaga atgcttcaga aactgtaaag tatctaaata atctgtacaa aataatccca   3360

aagactctga cttggcacag tgctaaaagg gagtgtctga aaagtaacat gcagctggtg   3420

agcatcacgg acccttacca gcaggcattc ctcagtgtgc aggcgctcct tcacaactct   3480

tccttatgga tcggactctt cagtcaagat gatgaactca actttggttg gtcagatggg   3540

aaacgtcttc attttagtcg ctgggctgaa actaatgggc aactcgaaga ctgtgtagta   3600

ttagacactg atggattctg gaaaacagtt gattgcaatg acaatcaacc aggtgctatt   3660

tgctactatt caggaaatga gactgaaaaa gaggtcaaac cagttgacag tgttaaatgt   3720

ccatctcctg ttctaaatac tccgtggata ccatttcaga actgttgcta caatttcata   3780

ataacaaaga ataggcatat ggcaacaaca caggatgaag ttcatactaa atgccagaaa   3840

ctgaatccaa aatcacatat tctgagtatt cgagatgaaa aggagaataa ctttgttctt   3900

gagcaactgc tgtacttcaa ttatatggct tcatgggtca tgttaggaat aacttataga   3960

aataagtctc ttatgtggtt tgataagacc ccactgtcat atacacattg gagagcagga   4020

agaccaacta taaaaaatga gaagtttttg gctggtttaa gtactgacgg cttctgggat   4080

attcaaacct ttaaagttat tgaagaagca gtttattttc accagcacag cattcttgct   4140

tgtaaaattg aaatggttga ctacaaagaa gaatataata ctacactgcc acagtttatg   4200

ccatatgaag atggtattta cagtgttatt caaaaaaagg taacatggta tgaagcatta   4260

aacatgtgtt ctcaaagtgg aggtcacttg gcaagcgttc acaaccaaaa tggccagctc   4320

tttctggaag atattgtaaa acgtgatgga tttccactat gggttgggct ctcaagtcat   4380

gatggaagtg aatcaagttt tgaatggtct gatggtagta catttgacta tatcccatgg   4440

aaaggccaaa catctcctgg aaattgtgtt ctcttggatc caaaaggaac ttggaaacat   4500

gaaaaatgca actctgttaa ggatggtgct atttgttata aacctacaaa atctaaaaag   4560

ctgtcccgtc ttacatattc atcaagatgt ccagcagcaa aagagaatgg gtcacggtgg   4620

atccagtaca agggtcactg ttacaagtct gatcaggcat tgcacagttt ttcagaggcc   4680

aaaaaattgt gttcaaaaca tgatcactct gcaactatcg tttccataaa agatgaagat   4740

gagaataaat ttgtgagcag actgatgagg gaaaataata acattaccat gagagtttgg   4800

cttggattat ctcaacattc tgttgactgt ccttcatcta cttggattca gttccaagac   4860

agttgttaca tttttctcca agaagccatc aaagtagaaa gcatagagga tgtcagaaat   4920

cagtgtactg accatggagc ggacatgata agcatacata atgaagaaga aaatgctttt   4980

atactggata ctttgaaaaa gcaatggaaa ggcccagatg atatcctact aggcatgttt   5040

tatgacacag atgatgcgag tttcaagtgg tttgataatt caaatatgac atttgataag   5100

tggacagacc aagatgatga tgaggattta gttgacacct gtgcttttct gcacatcaag   5160

acaggtgaat ggaaaaaagg aaattgtgaa gtttcttctg tggaaggaac actatgcaaa   5220

acagctatcc catacaaaag gaaatattta tcagataacc acattttaat atcagcattg   5280

gtgattgcta gcacggtaat tttgacagtt ttgggagcaa tcatttggtt cctgtacaaa   5340

aaacattctg attctcgttt caccacagtt ttttcaaccg caccccaatc accttataat   5400

gaagactgtg ttttggtagt tggagaagaa aatgaatatc ctgttcaatt tgactaagtt   5460

tttggtaatc ttgcactaag acatcaacaa aatgccctgg cagagataac ttgggaaaga   5520

ttttaatata aaacttgaca ttggatatta g                                  5551


<210>  8621
<211>  1817
<212>  PRT
<213>  Homosapiens

<400>  8621

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Cys Pro  Ser Ser Thr Trp Ile  Gln Phe Gln Asp Ser  Cys Tyr Ile 
    1610                 1615                 1620             


Phe Leu  Gln Glu Ala Ile Lys  Val Glu Ser Ile Glu  Asp Val Arg 
    1625                 1630                 1635             


Asn Gln  Cys Thr Asp His Gly  Ala Asp Met Ile Ser  Ile His Asn 
    1640                 1645                 1650             


Glu Glu  Glu Asn Ala Phe Ile  Leu Asp Thr Leu Lys  Lys Gln Trp 
    1655                 1660                 1665             


Lys Gly  Pro Asp Asp Ile Leu  Leu Gly Met Phe Tyr  Asp Thr Asp 
    1670                 1675                 1680             


Asp Ala  Ser Phe Lys Trp Phe  Asp Asn Ser Asn Met  Thr Phe Asp 
    1685                 1690                 1695             


Lys Trp  Thr Asp Gln Asp Asp  Asp Glu Asp Leu Val  Asp Thr Cys 
    1700                 1705                 1710             


Ala Phe  Leu His Ile Lys Thr  Gly Glu Trp Lys Lys  Gly Asn Cys 
    1715                 1720                 1725             


Glu Val  Ser Ser Val Glu Gly  Thr Leu Cys Lys Thr  Ala Ile Pro 
    1730                 1735                 1740             


Tyr Lys  Arg Lys Tyr Leu Ser  Asp Asn His Ile Leu  Ile Ser Ala 
    1745                 1750                 1755             


Leu Val  Ile Ala Ser Thr Val  Ile Leu Thr Val Leu  Gly Ala Ile 
    1760                 1765                 1770             


Ile Trp  Phe Leu Tyr Lys Lys  His Ser Asp Ser Arg  Phe Thr Thr 
    1775                 1780                 1785             


Val Phe  Ser Thr Ala Pro Gln  Ser Pro Tyr Asn Glu  Asp Cys Val 
    1790                 1795                 1800             


Leu Val  Val Gly Glu Glu Asn  Glu Tyr Pro Val Gln  Phe Asp 
    1805                 1810                 1815         


<210>  8622
<211>  5719
<212>  DNA
<213>  Homosapiens

<400>  8622
aggatgagga caggctgggc gacccctcgc cgcccggcgg ggctcctcat gctgctcttc     60

tggttcttcg atctcgcgga gccctctggc cgcgcagcta atgacccctt caccatcgtc    120

catggaaata cgggcaagtg catcaagcca gtgtatggct ggatagtagc agacgactgt    180

gatgaaactg aggacaagtt atggaagtgg gtgtcccagc atcggctctt tcatttgcac    240

tcccaaaagt gccttggcct cgatattacc aaatcggtaa atgagctgag aatgttcagc    300

tgtgactcca gtgccatgct gtggtggaaa tgtgagcacc actctctgta cggagctgcc    360

cggtaccggc tggctctgaa ggatggacat ggcacagcaa tctcaaatgc atctgatgtc    420

tggaagaaag gaggctcaga ggaaagcctt tgtgaccagc cttatcatga gatctatacc    480

agagatggga actcttatgg gagaccttgt gaatttccat tcttaattga tgggacctgg    540

catcatgatt gcattcttga tgaagatcat agtgggccat ggtgtgccac caccttaaat    600

tatgaatatg accgaaagtg gggcatctgc ttaaagcctg aaaacggttg tgaagataat    660

tgggaaaaga acgagcagtt tggaagttgc taccaattta atactcagac ggctctttct    720

tggaaagaag cttatgtttc atgtcagaat caaggagctg atttactgag catcaacagt    780

gctgctgaat taacttacct taaagaaaaa gaaggcattg ctaagatttt ctggattggt    840

ttaaatcagc tatactctgc tagaggctgg gaatggtcag accacaaacc attaaacttt    900

ctcaactggg atccagacag gcccagtgca cctactatag gtggctccag ctgtgcaaga    960

atggatgctg agtctggtct gtggcagagc ttttcctgtg aagctcaact gccctatgtc   1020

tgcaggaaac cattaaataa tacagtggag ttaacagatg tctggacata ctcagatacc   1080

cgctgtgatg caggctggct gccaaataat ggattttgct atctgctggt aaatgaaagt   1140

aattcctggg ataaggcaca tgcgaaatgc aaagccttca gtagtgacct aatcagcatt   1200

cattctctag cagatgtgga ggtggttgtc acaaaactcc ataatgagga tatcaaagaa   1260

gaagtgtgga taggccttaa gaacataaac ataccaactt tatttcagtg gtcagatggt   1320

actgaagtta ctctaacata ttgggatgag aatgagccaa atgttcccta caataagacg   1380

cccaactgtg tttcctactt aggagagcta ggtcagtgga aagtccaatc atgtgaggag   1440

aaactaaaat atgtatgcaa gagaaaggga gaaaaactga atgacgcaag ttctgataag   1500

atgtgtcctc cagatgaggg ctggaagaga catggagaaa cctgttacaa gatttatgag   1560

gatgaggtcc cttttggaac aaactgcaat ctgactatca ctagcagatt tgagcaagaa   1620

tacctaaatg atttgatgaa aaagtatgat aaatctctaa gaaaatactt ctggactggc   1680

ctgagagatg tagattcttg tggagagtat aactgggcaa ctgttggtgg aagaaggcgg   1740

gctgtaacct tttccaactg gaattttctt gagccagctt ccccgggcgg ctgcgtggct   1800

atgtctactg gaaagtctgt tggaaagtgg gaggtgaagg actgcagaag cttcaaagca   1860

ctttcaattt gcaagaaaat gagtggaccc cttgggcctg aagaagcatc ccctaagcct   1920

gatgacccct gtcctgaagg ctggcagagt ttccccgcaa gtctttcttg ttataaggta   1980

ttccatgcag aaagaattgt aagaaagagg aactgggaag aagctgaacg attctgccaa   2040

gcccttggag cacacctttc tagcttcagc catgtggatg aaataaagga atttcttcac   2100

tttttaacgg accagttcag tggccagcat tggctgtgga ttggtttgaa taaaaggagc   2160

ccagatttac aaggatcctg gcaatggagt gatcgtacac cagtgtctac tattatcatg   2220

ccaaatgagt ttcagcagga ttatgacatc agagactgtg ctgctgtcaa ggtatttcat   2280

aggccatggc gaagaggctg gcatttctat gatgatagag aatttattta tttgaggcct   2340

tttgcttgtg atacaaaact tgaatgggtg tgccaaattc caaaaggccg tactccaaaa   2400

acaccagact ggtacaatcc agaccgtgct ggaattcatg gacctccact tataattgaa   2460

ggaagtgaat attggtttgt tgctgatctt cacctaaact atgaagaagc cgtcctgtac   2520

tgtgccagca atcacagctt tcttgcaact ataacatctt ttgtgggact aaaagccatc   2580

aaaaacaaaa tagcaaatat atctggtgat ggacagaagt ggtggataag aattagcgag   2640

tggccaatag atgatcattt tacatactca cgatatccat ggcaccgctt tcctgtgaca   2700

tttggagagg aatgcttgta catgtctgcc aagacttggc ttatcgactt aggtaaacca   2760

acagactgta gtaccaagtt gcccttcatc tgtgaaaaat ataatgtttc ttcgttagag   2820

aaatacagcc cagattctgc agctaaagtg caatgttctg agcaatggat tccttttcag   2880

aataagtgtt ttctaaagat caaacccgtg tctctcacat tttctcaagc aagcgatacc   2940

tgtcactcct atggtggcac ccttccttca gtgttgagcc agattgaaca agactttatt   3000

acatccttgc ttccggatat ggaagctact ttatggattg gtttgcgctg gactgcctat   3060

gaaaagataa acaaatggac agataacaga gagctgacgt acagtaactt tcacccatta   3120

ttggttagtg ggaggctgag aataccagaa aatttttttg aggaagagtc tcgctaccac   3180

tgtgccctaa tactcaacct ccaaaaatca ccgtttactg ggacgtggaa ttttacatcc   3240

tgcagtgaac gccactttgt gtctctctgt cagaaatatt cagaagttaa aagcagacag   3300

acgttgcaga atgcttcaga aactgtaaag tatctaaata atctgtacaa aataatccca   3360

aagactctga cttggcacag tgctaaaagg gagtgtctga aaagtaacat gcagctggtg   3420

agcatcacgg acccttacca gcaggcattc ctcagtgtgc aggcgctcct tcacaactct   3480

tccttatgga tcggactctt cagtcaagat gatgaactca actttggttg gtcagatggg   3540

aaacgtcttc attttagtcg ctgggctgaa actaatgggc aactcgaaga ctgtgtagta   3600

ttagacactg atggattctg gaaaacagtt gattgcaatg acaatcaacc aggtgctatt   3660

tgctactatt caggaaatga gactgaaaaa gaggtcaaac cagttgacag tgttaaatgt   3720

ccatctcctg ttctaaatac tccgtggata ccatttcaga actgttgcta caatttcata   3780

ataacaaaga ataggcatat ggcaacaaca caggatgaag ttcatactaa atgccagaaa   3840

ctgaatccaa aatcacatat tctgagtatt cgagatgaaa aggagaataa ctttgttctt   3900

gagcaactgc tgtacttcaa ttatatggct tcatgggtca tgttaggaat aacttataga   3960

aataagtctc ttatgtggtt tgataagacc ccactgtcat atacacattg gagagcagga   4020

agaccaacta taaaaaatga gaagtttttg gctggtttaa gtactgacgg cttctgggat   4080

attcaaacct ttaaagttat tgaagaagca gtttattttc accagcacag cattcttgct   4140

tgtaaaattg aaatggttga ctacaaagaa gaatataata ctacactgcc acagtttatg   4200

ccatatgaag atggtattta cagtgttatt caaaaaaagg taacatggta tgaagcatta   4260

aacatgtgtt ctcaaagtgg aggtcacttg gcaagcgttc acaaccaaaa tggccagctc   4320

tttctggaag atattgtaaa acgtgatgga tttccactat gggttgggct ctcaagtcat   4380

gatggaagtg aatcaagttt tgaatggtct gatggtagta catttgacta tatcccatgg   4440

aaaggccaaa catctcctgg aaattgtgtt ctcttggatc caaaaggaac ttggaaacat   4500

gaaaaatgca actctgttaa ggatggtgct atttgttata aacctacaaa atctaaaaag   4560

ctgtcccgtc ttacatattc atcaagatgt ccagcagcaa aagagaatgg gtcacggtgg   4620

atccagtaca agggtcactg ttacaagtct gatcaggcat tgcacagttt ttcagaggcc   4680

aaaaaattgt gttcaaaaca tgatcactct gcaactatcg tttccataaa agatgaagat   4740

gagaataaat ttgtgagcag actgatgagg gaaaataata acattaccat gagagtttgg   4800

cttggattat ctcaacattc tgttgaccag tcttggagtt ggttagatgg atcagaagtg   4860

acatttgtca aatgggaaaa taaaagtaag agtggtgttg gaagatgtag catgttgata   4920

gcttcaaatg aaacttggaa aaaagttgaa tgtgaacatg gttttggaag agttgtctgc   4980

aaagtgcctc tggactgtcc ttcatctact tggattcagt tccaagacag ttgttacatt   5040

tttctccaag aagccatcaa agtagaaagc atagaggatg tcagaaatca gtgtactgac   5100

catggagcgg acatgataag catacataat gaagaagaaa atgcttttat actggatact   5160

ttgaaaaagc aatggaaagg cccagatgat atcctactag gcatgtttta tgacacagat   5220

gatgcgagtt tcaagtggtt tgataattca aatatgacat ttgataagtg gacagaccaa   5280

gatgatgatg aggatttagt tgacacctgt gcttttctgc acatcaagac aggtgaatgg   5340

aaaaaaggaa attgtgaagt ttcttctgtg gaaggaacac tatgcaaaac agctatccca   5400

tacaaaagga aatatttatc agataaccac attttaatat cagcattggt gattgctagc   5460

acggtaattt tgacagtttt gggagcaatc atttggttcc tgtacaaaaa acattctgat   5520

tctcgtttca ccacagtttt ttcaaccgca ccccaatcac cttataatga agactgtgtt   5580

ttggtagttg gagaagaaaa tgaatatcct gttcaatttg actaagtttt tggtaatctt   5640

gcactaagac atcaacaaaa tgccctggca gagataactt gggaaagatt ttaatataaa   5700

acttgacatt ggatattag                                                5719


<210>  8623
<211>  1873
<212>  PRT
<213>  Homosapiens

<400>  8623

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Gln Ser  Trp Ser Trp Leu Asp  Gly Ser Glu Val Thr  Phe Val Lys 
    1610                 1615                 1620             


Trp Glu  Asn Lys Ser Lys Ser  Gly Val Gly Arg Cys  Ser Met Leu 
    1625                 1630                 1635             


Ile Ala  Ser Asn Glu Thr Trp  Lys Lys Val Glu Cys  Glu His Gly 
    1640                 1645                 1650             


Phe Gly  Arg Val Val Cys Lys  Val Pro Leu Asp Cys  Pro Ser Ser 
    1655                 1660                 1665             


Thr Trp  Ile Gln Phe Gln Asp  Ser Cys Tyr Ile Phe  Leu Gln Glu 
    1670                 1675                 1680             


Ala Ile  Lys Val Glu Ser Ile  Glu Asp Val Arg Asn  Gln Cys Thr 
    1685                 1690                 1695             


Asp His  Gly Ala Asp Met Ile  Ser Ile His Asn Glu  Glu Glu Asn 
    1700                 1705                 1710             


Ala Phe  Ile Leu Asp Thr Leu  Lys Lys Gln Trp Lys  Gly Pro Asp 
    1715                 1720                 1725             


Asp Ile  Leu Leu Gly Met Phe  Tyr Asp Thr Asp Asp  Ala Ser Phe 
    1730                 1735                 1740             


Lys Trp  Phe Asp Asn Ser Asn  Met Thr Phe Asp Lys  Trp Thr Asp 
    1745                 1750                 1755             


Gln Asp  Asp Asp Glu Asp Leu  Val Asp Thr Cys Ala  Phe Leu His 
    1760                 1765                 1770             


Ile Lys  Thr Gly Glu Trp Lys  Lys Gly Asn Cys Glu  Val Ser Ser 
    1775                 1780                 1785             


Val Glu  Gly Thr Leu Cys Lys  Thr Ala Ile Pro Tyr  Lys Arg Lys 
    1790                 1795                 1800             


Tyr Leu  Ser Asp Asn His Ile  Leu Ile Ser Ala Leu  Val Ile Ala 
    1805                 1810                 1815             


Ser Thr  Val Ile Leu Thr Val  Leu Gly Ala Ile Ile  Trp Phe Leu 
    1820                 1825                 1830             


Tyr Lys  Lys His Ser Asp Ser  Arg Phe Thr Thr Val  Phe Ser Thr 
    1835                 1840                 1845             


Ala Pro  Gln Ser Pro Tyr Asn  Glu Asp Cys Val Leu  Val Val Gly 
    1850                 1855                 1860             


Glu Glu  Asn Glu Tyr Pro Val  Gln Phe Asp 
    1865                 1870             


<210>  8624
<211>  597
<212>  DNA
<213>  Homosapiens

<400>  8624
acccgccgtc atgctccggg ccgcgctgcc cgcgctcctg ctgccgttgc tgggcctcgc     60

cgctgctgcc gtcgcggact gtccttcatc tacttggatt cagttccaag acagttgtta    120

catttttctc caagaagcca tcaaagtaga aagcatagag gatgtcagaa atcagtgtac    180

tgaccatgga gcggacatga taagcataca taatgaagaa gaaaatgctt ttatactgga    240

tactttgaaa aagcaatgga aaggcccaga tgatatccta ctaggcatgt tttatgacac    300

agatgatgcg agtttcaagt ggtttgataa ttcaaatatg acatttgata agtggacaga    360

ccaagatgat gatgaggatt tagttgacac ctgtgctttt ctgcacatca agacaggtga    420

atggaaaaaa ggaaattgtg aagtttcttc tgtggaagga acactatgca aaacagctat    480

cagataacca cattttaata tcagcattgg tgattgctag cacggtaatt ttgacagttt    540

tgggagcaat catttggttc ctgtacaaaa aacattctga ttctcgtttc accacag       597


<210>  8625
<211>  158
<212>  PRT
<213>  Homosapiens

<400>  8625

Met Leu Arg Ala Ala Leu Pro Ala Leu Leu Leu Pro Leu Leu Gly Leu 
1               5                   10                  15      


Ala Ala Ala Ala Val Ala Asp Cys Pro Ser Ser Thr Trp Ile Gln Phe 
            20                  25                  30          


Gln Asp Ser Cys Tyr Ile Phe Leu Gln Glu Ala Ile Lys Val Glu Ser 
        35                  40                  45              


Ile Glu Asp Val Arg Asn Gln Cys Thr Asp His Gly Ala Asp Met Ile 
    50                  55                  60                  


Ser Ile His Asn Glu Glu Glu Asn Ala Phe Ile Leu Asp Thr Leu Lys 
65                  70                  75                  80  


Lys Gln Trp Lys Gly Pro Asp Asp Ile Leu Leu Gly Met Phe Tyr Asp 
                85                  90                  95      


Thr Asp Asp Ala Ser Phe Lys Trp Phe Asp Asn Ser Asn Met Thr Phe 
            100                 105                 110         


Asp Lys Trp Thr Asp Gln Asp Asp Asp Glu Asp Leu Val Asp Thr Cys 
        115                 120                 125             


Ala Phe Leu His Ile Lys Thr Gly Glu Trp Lys Lys Gly Asn Cys Glu 
    130                 135                 140                 


Val Ser Ser Val Glu Gly Thr Leu Cys Lys Thr Ala Ile Arg 
145                 150                 155             


<210>  8626
<211>  368
<212>  DNA
<213>  Homosapiens

<400>  8626
tatgtgagat ggtgacacat cctataggga aaacaggcag ataaggatga attccagtgc     60

aagaagggag gtgttgcact ttatttttat ttttagtaca gtggccaggg aaggcctcat    120

ttaataaggc catgattttg cataatgaag acctaaagtc aaagtgaaag cctgtcatgt    180

agatagggat taggcttagt ctgactttaa ggagtaaaac agtagagaac atggagttga    240

agcagcaagg aaacaaccca acagttaagt gtagctgcca tcttggcaaa cagggagttc    300

cccttcatac caagggtaag ctggaattca ggttagaaga aatttggaag tagggctaca    360

cacacata                                                             368


<210>  8627
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  8627

Met Glu Leu Lys Gln Gln Gly Asn Asn Pro Thr Val Lys Cys Ser Cys 
1               5                   10                  15      


His Leu Gly Lys Gln Gly Val Pro Leu His Thr Lys Gly Lys Leu Glu 
            20                  25                  30          


Phe Arg Leu Glu Glu Ile Trp Lys 
        35                  40  


<210>  8628
<211>  1514
<212>  DNA
<213>  Homosapiens

<400>  8628
actttttcag ttgtttagat cttaggcatg tgctggtatc cacagttaat tccctgctaa     60

atgccatgtt tatcacccta attaatagaa tggaggggac tccaaagctg gaactgaagt    120

ccaaattgtt tgtacagtaa tatgtttaat gttcattttc tctgtatgaa tgtgattggt    180

aactaggata tgtatatttt aatagaattt ttaacaaaac ttcttagaaa attaaaatag    240

gcatattact aggtgacatg tctacttttt aatttttaag agcatccggc caaatgcaaa    300

attagtacct caaagtaaaa attgaactgt aaactctatc agcattgttt caaaatagtc    360

atttttagca ctggggaaaa ataaacaata agacatgctt actttttaat ttttattttt    420

ttgagactga gtctctctct gttgcccagg ctggagtaca atggcgtgat ctcggctcac    480

tgcaaatctc cgcctcccag gttcaagcga ttctcctgcc tcagcctcct gagtagctgg    540

gattacaggc aactgccacc atgcccggct aatttttgta tttttagtag agatggggtt    600

tcaccatgtt ggccaggctg gtctcgaact cgtgaccgca ggtgatcctc ccgcctcggc    660

ctcccaaagt gctgggatta caggcatgag ccaccgcgcc tggcctctgc ttacttttta    720

tatagcaaaa tgattcctct tggcaagatg tttcttatat tattccaaag ttatttcata    780

ccattattat gtaaatatga agagtttttt tctgtttata attgtttata aaacaatgac    840

ttttaaagat ttagtgctta acattttccc aagtgtggga acattatttt tagattgagt    900

aggtaccttg tagcagtgtg ctttgcattt tctgatgtat tacatgactg tttcttttgt    960

aaagagaatc aactaggtat ttaagatttt ttaacatgtg ttaaacagag aaagggtcca   1020

tgaaggaaag tgtatgagtt gcatttgtaa aaatgagact ttttcagtgg aactctaaac   1080

cttgtgatga ctactaacaa atgtaaaatt atgagtgatt aagaaaacat tgctttgtgg   1140

ttatcacttt aagttttgac acctagatta tagtcttagt aatagcatcc actggaaaag   1200

gtgaaaatgt tttattcggc atttaactta catttgtact ttatttttgt ataaaatcca   1260

tagatttatt ttacatttag agtatttaca ctatgataaa gttgtaaata attttctaag   1320

acagttttta tatagtctac agttgtcctg atttcttatt gaatttgtta gactagttct   1380

cttgtcctgt gatctgtgta caattttagt cactaagact ttcctccaag aactaagcca   1440

acttgatgtg aaaagcacag ctgtatataa tggtgatgtc ataataaagt tgttttatct   1500

tttaagtaaa agta                                                     1514


<210>  8629
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  8629

Met Gly Phe His His Val Gly Gln Ala Gly Leu Glu Leu Val Thr Ala 
1               5                   10                  15      


Gly Asp Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Met 
            20                  25                  30          


Ser His Arg Ala Trp Pro Leu Leu Thr Phe Tyr Ile Ala Lys 
        35                  40                  45      


<210>  8630
<211>  6909
<212>  DNA
<213>  Homosapiens

<400>  8630
ggcgggagcc gcgtgcgccc gaggacccgg ccggaaggct tgcgccagct caggatgagg     60

acaggctggg cgacccctcg ccgcccggcg gggctcctca tgctgctctt ctggttcttc    120

gatctcgcgg agccctctgg ccgcgcagct aatgacccct tcaccatcgt ccatggaaat    180

acgggcaagt gcatcaagcc agtgtatggc tggatagtag cagacgactg tgatgaaact    240

gaggacaagt tatggaagtg ggtgtcccag catcggctct ttcatttgca ctcccaaaag    300

tgccttggcc tcgatattac caaatcggta aatgagctga gaatgttcag ctgtgactcc    360

agtgccatgc tgtggtggaa atgtgagcac cactctctgt acggagctgc ccggtaccgg    420

ctggctctga aggatggaca tggcacagca atctcaaatg catctgatgt ctggaagaaa    480

ggaggctcag aggaaagcct ttgtgaccag ccttatcatg agatctatac cagagatggg    540

aactcttatg ggagaccttg tgaatttcca ttcttaattg atgggacctg gcatcatgat    600

tgcattcttg atgaagatca tagtgggcca tggtgtgcca ccaccttaaa ttatgaatat    660

gaccgaaagt ggggcatctg cttaaagcct gaaaacggtt gtgaagataa ttgggaaaag    720

aacgagcagt ttggaagttg ctaccaattt aatactcaga cggctctttc ttggaaagaa    780

gcttatgttt catgtcagaa tcaaggagct gatttactga gcatcaacag tgctgctgaa    840

ttaacttacc ttaaagaaaa agaaggcatt gctaagattt tctggattgg tttaaatcag    900

ctatactctg ctagaggctg ggaatggtca gaccacaaac cattaaactt tctcaactgg    960

gatccagaca ggcccagtgc acctactata ggtggctcca gctgtgcaag aatggatgct   1020

gagtctggtc tgtggcagag cttttcctgt gaagctcaac tgccctatgt ctgcaggaaa   1080

ccattaaata atacagtgga gttaacagat gtctggacat actcagatac ccgctgtgat   1140

gcaggctggc tgccaaataa tggattttgc tatctgctgg taaatgaaag taattcctgg   1200

gataaggcac atgcgaaatg caaagccttc agtagtgacc taatcagcat tcattctcta   1260

gcagatgtgg aggtggttgt cacaaaactc cataatgagg atatcaaaga agaagtgtgg   1320

ataggcctta agaacataaa cataccaact ttatttcagt ggtcagatgg tactgaagtt   1380

actctaacat attgggatga gaatgagcca aatgttccct acaataagac gcccaactgt   1440

gtttcctact taggagagct aggtcagtgg aaagtccaat catgtgagga gaaactaaaa   1500

tatgtatgca agagaaaggg agaaaaactg aatgacgcaa gttctgataa gatgtgtcct   1560

ccagatgagg gctggaagag acatggagaa acctgttaca agatttatga ggatgaggtc   1620

ccttttggaa caaactgcaa tctgactatc actagcagat ttgagcaaga atacctaaat   1680

gatttgatga aaaagtatga taaatctcta agaaaatact tctggactgg cctgagagat   1740

gtagattctt gtggagagta taactgggca actgttggtg gaagaaggcg ggctgtaacc   1800

ttttccaact ggaattttct tgagccagct tccccgggcg gctgcgtggc tatgtctact   1860

ggaaagtctg ttggaaagtg ggaggtgaag gactgcagaa gcttcaaagc actttcaatt   1920

tgcaagaaaa tgagtggacc ccttgggcct gaagaagcat cccctaagcc tgatgacccc   1980

tgtcctgaag gctggcagag tttccccgca agtctttctt gttataaggt attccatgca   2040

gaaagaattg taagaaagag gaactgggaa gaagctgaac gattctgcca agcccttgga   2100

gcacaccttt ctagcttcag ccatgtggat gaaataaagg aatttcttca ctttttaacg   2160

gaccagttca gtggccagca ttggctgtgg attggtttga ataaaaggag cccagattta   2220

caaggatcct ggcaatggag tgatcgtaca ccagtgtcta ctattatcat gccaaatgag   2280

tttcagcagg attatgacat cagagactgt gctgctgtca aggtatttca taggccatgg   2340

cgaagaggct ggcatttcta tgatgataga gaatttattt atttgaggcc ttttgcttgt   2400

gatacaaaac ttgaatgggt gtgccaaatt ccaaaaggcc gtactccaaa aacaccagac   2460

tggtacaatc cagaccgtgc tggaattcat ggacctccac ttataattga aggaagtgaa   2520

tattggtttg ttgctgatct tcacctaaac tatgaagaag ccgtcctgta ctgtgccagc   2580

aatcacagct ttcttgcaac tataacatct tttgtgggac taaaagccat caaaaacaaa   2640

atagcaaata tatctggtga tggacagaag tggtggataa gaattagcga gtggccaata   2700

gatgatcatt ttacatactc acgatatcca tggcaccgct ttcctgtgac atttggagag   2760

gaatgcttgt acatgtctgc caagacttgg cttatcgact taggtaaacc aacagactgt   2820

agtaccaagt tgcccttcat ctgtgaaaaa tataatgttt cttcgttaga gaaatacagc   2880

ccagattctg cagctaaagt gcaatgttct gagcaatgga ttccttttca gaataagtgt   2940

tttctaaaga tcaaacccgt gtctctcaca ttttctcaag caagcgatac ctgtcactcc   3000

tatggtggca cccttccttc agtgttgagc cagattgaac aagactttat tacatccttg   3060

cttccggata tggaagctac tttatggatt ggtttgcgct ggactgccta tgaaaagata   3120

aacaaatgga cagataacag agagctgacg tacagtaact ttcacccatt attggttagt   3180

gggaggctga gaataccaga aaattttttt gaggaagagt ctcgctacca ctgtgcccta   3240

atactcaacc tccaaaaatc accgtttact gggacgtgga attttacatc ctgcagtgaa   3300

cgccactttg tgtctctctg tcagaaatat tcagaagtta aaagcagaca gacgttgcag   3360

aatgcttcag aaactgtaaa gtatctaaat aatctgtaca aaataatccc aaagactctg   3420

acttggcaca gtgctaaaag ggagtgtctg aaaagtaaca tgcagctggt gagcatcacg   3480

gacccttacc agcaggcatt cctcagtgtg caggcgctcc ttcacaactc ttccttatgg   3540

atcggactct tcagtcaaga tgatgaactc aactttggtt ggtcagatgg gaaacgtctt   3600

cattttagtc gctgggctga aactaatggg caactcgaag actgtgtagt attagacact   3660

gatggattct ggaaaacagt tgattgcaat gacaatcaac caggtgctat ttgctactat   3720

tcaggaaatg agactgaaaa agaggtcaaa ccagttgaca gtgttaaatg tccatctcct   3780

gttctaaata ctccgtggat accatttcag aactgttgct acaatttcat aataacaaag   3840

aataggcata tggcaacaac acaggatgaa gttcatacta aatgccagaa actgaatcca   3900

aaatcacata ttctgagtat tcgagatgaa aaggagaata actttgttct tgagcaactg   3960

ctgtacttca attatatggc ttcatgggtc atgttaggaa taacttatag aaataagtct   4020

cttatgtggt ttgataagac cccactgtca tatacacatt ggagagcagg aagaccaact   4080

ataaaaaatg agaagttttt ggctggttta agtactgacg gcttctggga tattcaaacc   4140

tttaaagtta ttgaagaagc agtttatttt caccagcaca gcattcttgc ttgtaaaatt   4200

gaaatggttg actacaaaga agaatataat actacactgc cacagtttat gccatatgaa   4260

gatggtattt acagtgttat tcaaaaaaag gtaacatggt atgaagcatt aaacatgtgt   4320

tctcaaagtg gaggtcactt ggcaagcgtt cacaaccaaa atggccagct ctttctggaa   4380

gatattgtaa aacgtgatgg atttccacta tgggttgggc tctcaagtca tgatggaagt   4440

gaatcaagtt ttgaatggtc tgatggtagt acatttgact atatcccatg gaaaggccaa   4500

acatctcctg gaaattgtgt tctcttggat ccaaaaggaa cttggaaaca tgaaaaatgc   4560

aactctgtta aggatggtgc tatttgttat aaacctacaa aatctaaaaa gctgtcccgt   4620

cttacatatt catcaagatg tccagcagca aaagagaatg ggtcacggtg gatccagtac   4680

aagggtcact gttacaagtc tgatcaggca ttgcacagtt tttcagaggc caaaaaattg   4740

tgttcaaaac atgatcactc tgcaactatc gtttccataa aagatgaaga tgagaataaa   4800

tttgtgagca gactgatgag ggaaaataat aacattacca tgagagtttg gcttggatta   4860

tctcaacatt ctgttgacca gtcttggagt tggttagatg gatcagaagt gacatttgtc   4920

aaatgggaaa ataaaagtaa gagtggtgtt ggaagatgta gcatgttgat agcttcaaat   4980

gaaacttgga aaaaagttga atgtgaacat ggttttggaa gagttgtctg caaagtgcct   5040

ctgggccctg attacacagc aatagctatc atagttgcca cactaagtat cttagttctc   5100

atgggcggac tgatttggtt cctcttccaa aggcaccgtt tgcacctggc gggtttctca   5160

tcagttcgat atgcacaagg agtgaatgaa gatgagatta tgcttccttc tttccatgac   5220

taaattcttc taaaagtttt ctaatttgca ctaatgtgtt atgagaaatt agtcacttaa   5280

aatgtcccag tgtcagtatt tactctgctc caaagtagaa ctcttaaata ctttttcagt   5340

tgtttagatc ttaggcatgt gctggtatcc acagttaatt ccctgctaaa tgccatgttt   5400

atcaccctaa ttaatagaat ggaggggact ccaaagctgg aactgaagtc caaattgttt   5460

gtacagtaat atgtttaatg ttcattttct ctgtatgaat gtgattggta actaggatat   5520

gtatatttta atagaatttt taacaaaact tcttagaaaa ttaaaatagg catattacta   5580

ggtgacatgt ctacttttta atttttaaga gcatccggcc aaatgcaaaa ttagtacctc   5640

aaagtaaaaa ttgaactgta aactctatca gcattgtttc aaaatagtca tttttagcac   5700

tggggaaaaa taaacaataa gacatgctta ctttttaatt tttatttttt tgagactgag   5760

tctctctctg ttgcccaggc tggagtacaa tggcgtgatc tcggctcact gcaaatctcc   5820

gcctcccagg ttcaagcgat tctcctgcct cagcctcctg agtagctggg attacaggca   5880

actgccacca tgcccggcta atttttgtat ttttagtaga gatggggttt caccatgttg   5940

gccaggctgg tctcgaactc gtgaccgcag gtgatcctcc cgcctcggcc tcccaaagtg   6000

ctgggattac aggcatgagc caccgcgcct ggcctctgct tactttttat atagcaaaat   6060

gattcctctt ggcaagatgt ttcttatatt attccaaagt tatttcatac cattattatg   6120

taaatatgaa gagttttttt ctgtttataa ttgtttataa aacaatgact tttaaagatt   6180

tagtgcttaa cattttccca agtgtgggaa cattattttt agattgagta ggtaccttgt   6240

agcagtgtgc tttgcatttt ctgatgtatt acatgactgt ttcttttgta aagagaatca   6300

actaggtatt taagactgat aattttacaa tttatatgct tcacatagca tgtcaacttt   6360

tgactaagaa ttttgtttta cttttttaac atgtgttaaa cagagaaagg gtccatgaag   6420

gaaagtgtat gagttgcatt tgtaaaaatg agactttttc agtggaactc taaaccttgt   6480

gatgactact aacaaatgta aaattatgag tgattaagaa aacattgctt tgtggttatc   6540

actttaagtt ttgacaccta gattatagtc ttagtaatag catccactgg aaaaggtgaa   6600

aatgttttat tcggcattta acttacattt gtactttatt tttgtataaa atccatagat   6660

ttattttaca tttagagtat ttacactatg ataaagttgt aaataatttt ctaagacagt   6720

ttttatatag tctacagttg tcctgatttc ttattgaatt tgttagacta gttctcttgt   6780

cctgtgatct gtgtacaatt ttagtcacta agactttcct ccaagaacta agccaacttg   6840

atgtgaaaag cacagctgta tataatggtg atgtcataat aaagttgttt tatcttttaa   6900

gtaaaagta                                                           6909


<210>  8631
<211>  1722
<212>  PRT
<213>  Homosapiens

<400>  8631

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Gln Ser  Trp Ser Trp Leu Asp  Gly Ser Glu Val Thr  Phe Val Lys 
    1610                 1615                 1620             


Trp Glu  Asn Lys Ser Lys Ser  Gly Val Gly Arg Cys  Ser Met Leu 
    1625                 1630                 1635             


Ile Ala  Ser Asn Glu Thr Trp  Lys Lys Val Glu Cys  Glu His Gly 
    1640                 1645                 1650             


Phe Gly  Arg Val Val Cys Lys  Val Pro Leu Gly Pro  Asp Tyr Thr 
    1655                 1660                 1665             


Ala Ile  Ala Ile Ile Val Ala  Thr Leu Ser Ile Leu  Val Leu Met 
    1670                 1675                 1680             


Gly Gly  Leu Ile Trp Phe Leu  Phe Gln Arg His Arg  Leu His Leu 
    1685                 1690                 1695             


Ala Gly  Phe Ser Ser Val Arg  Tyr Ala Gln Gly Val  Asn Glu Asp 
    1700                 1705                 1710             


Glu Ile  Met Leu Pro Ser Phe  His Asp 
    1715                 1720         


<210>  8632
<211>  1040
<212>  DNA
<213>  Homosapiens

<400>  8632
gcggggctcc tcatgctgct cttctggttc ttcgatctcg cggagccctc tggccgcgca     60

gagcagactt gtggccttgt ttggggaagc actggaattt tgaaccccca gccatttggg    120

tcaattgttt ggcaagagtg tccgcttcat gatgctggtg atggcatgca cctcgtcaca    180

tgtgcacggc taggcttgtg caggtggcct ctattaccca aacactgaag gagcccctct    240

gtgtccttgg agagatgcca ggtgcttagt ttacattttt gcctgcttgg agagctaaca    300

gcttgaagta aaccaatcca tcagggactc ctgaggtttt caccagccaa caccacccaa    360

tcgtgcgtga agactttctg actccctgga cattgccatg gactcaactg tcacttcagg    420

acctgttttt gaactaacaa acctagactt ctgattctct cttgctgcac ctacctgtac    480

attccgaaca catggtagag actctacaaa atgcttaata tgtgatctat ggacggttcc    540

cctgaaatta taaatgctgc catcttcatc cttcttgttt tcccaagcta tttccctatc    600

catttgtctg tggttataaa tgtcaatatc cagcttctct ttggaatgtg tgaagctctt    660

tggtctaggg accaaaggca ggaattattt agtgatcaga caataagaaa acactgaaag    720

agatgatttg cctttgatgg atgtaaaaat actaaaaatt tattttcaat ttatggtaat    780

gctacttagc cattttctct caaacaccac tggagaattt atataacatg aagcatatac    840

aaaatgcatc tagggggtaa tgaggcttct cttcatcaac ttctgccttt tagatttgcc    900

ccaatattgt acttggaggt aaatattaaa actccattga ggactggtat aaagttgtaa    960

agtgaacaaa acccagtaga aagctattga taaagaatct attttataaa ataagtttta   1020

tacaataaaa tctactctgt                                               1040


<210>  8633
<211>  71
<212>  PRT
<213>  Homosapiens

<400>  8633

Met Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala 
1               5                   10                  15      


Glu Gln Thr Cys Gly Leu Val Trp Gly Ser Thr Gly Ile Leu Asn Pro 
            20                  25                  30          


Gln Pro Phe Gly Ser Ile Val Trp Gln Glu Cys Pro Leu His Asp Ala 
        35                  40                  45              


Gly Asp Gly Met His Leu Val Thr Cys Ala Arg Leu Gly Leu Cys Arg 
    50                  55                  60                  


Trp Pro Leu Leu Pro Lys His 
65                  70      


<210>  8634
<211>  1672
<212>  DNA
<213>  Homosapiens

<400>  8634
aggccgcgct cagcaggcgg ggcgggagcc gcgtgcgccc gaggacccgg ccggaaggct     60

tgcgccagct caggatgagg acaggctggg cgacccctcg ccgcccggcg gggctcctca    120

tgctgctctt ctggttcttc gatctcgcgg agccctctgg ccgcgcagct aagctaagtt    180

accatctggt ttagacttcc ttcggagagc gatgggaaga gatttctcag agtgtgaatg    240

gcatcatcct atctacagca aggacctgga aatgaaccct gctctgagtc acacttctct    300

attctccttt gaccctgtgt gctaggaact accaaaagaa tcctttaaaa taagatcctt    360

tattgccttg ataatttatt ctgcctgccc cacaatccaa ggtggaaaag ttcactgcag    420

caactaacta cagtgaaaat gcactaactt ttcaatcact aacctcttgg ttcccatcga    480

catctgcttc agtcctgttt ttatctcctt cacaaatttc aggatttccc taattcttgc    540

aatctctgca atcactgccc tttatcactg acccaaagca aaaagcacca ggtttaactc    600

tgttccccct gtgctaggtc cccacaggtt ttgttatcct gtatccttcc ttactcctag    660

cagctactct gatcgatttt ctctcaccct cagagcagac ttgtggcctt gtttggggaa    720

gcactggaat tttgaacccc cagccatttg ggtcaattgt ttggcaagag tgtccgcttc    780

atgatgctgg tgatggcatg cacctcgtca catgtgcacg gctaggcttg tgcaggtggc    840

ctctattacc caaacactga aggagcccct ctgtgtcctt ggagagatgc caggtgctta    900

gtttacattt ttgcctgctt ggagagctaa cagcttgaag taaaccaatc catcagggac    960

tcctgaggtt ttcaccagcc aacaccaccc aatcgtgcgt gaagactttc tgactccctg   1020

gacattgcca tggactcaac tgtcacttca ggacctgttt ttgaactaac aaacctagac   1080

ttctgattct ctcttgctgc acctacctgt acattccgaa cacatggtag agactctaca   1140

aaatgcttaa tatgtgatct atggacggtt cccctgaaat tataaatgct gccatcttca   1200

tccttcttgt tttcccaagc tatttcccta tccatttgtc tgtggttata aatgtcaata   1260

tccagcttct ctttggaatg tgtgaagctc tttggtctag ggaccaaagg caggaattat   1320

ttagtgatca gacaataaga aaacactgaa agagatgatt tgcctttgat ggatgtaaaa   1380

atactaaaaa tttattttca atttatggta atgctactta gccattttct ctcaaacacc   1440

actggagaat ttatataaca tgaagcatat acaaaatgca tctagggggt aatgaggctt   1500

ctcttcatca acttctgcct tttagatttg ccccaatatt gtacttggag gtaaatatta   1560

aaactccatt gaggactggt ataaagttgt aaagtgaaca aaacccagta gaaagctatt   1620

gataaagaat ctattttata aaataagttt tatacaataa aatctactct gt           1672


<210>  8635
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  8635

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Lys Leu Ser Tyr His Leu Val 
        35                  


<210>  8636
<211>  390
<212>  DNA
<213>  Homosapiens

<400>  8636
agttgaaggc tgcagtgagc tatggttgca ccactgcact cctgcctggg caactgaatg     60

agaccccacc tcaaaaaagt gctgttctag aaacagaggt actaagatga cacctaaagg    120

tgcaaaagaa aaccatctct gcacactacc aaacagacag tgcgtgaacg aagcagaccc    180

tcctgaccac agccaaggac tggagagctt ggtgaaactg gtgctcaagg tagaaattcc    240

ctgcgattgc tactgcaact tatactaaac gtcccaagtg aagtgaaggg agaaaaaaga    300

gatattaagc aagaaggccc acttgtttat gcattgcttt agaagataat ctgtaattgc    360

atattaataa gtaaagttaa cgttacactt                                     390


<210>  8637
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  8637

Met Thr Pro Lys Gly Ala Lys Glu Asn His Leu Cys Thr Leu Pro Asn 
1               5                   10                  15      


Arg Gln Cys Val Asn Glu Ala Asp Pro Pro Asp His Ser Gln Gly Leu 
            20                  25                  30          


Glu Ser Leu Val Lys Leu Val Leu Lys Val Glu Ile Pro Cys Asp Cys 
        35                  40                  45              


Tyr Cys Asn Leu Tyr 
    50              


<210>  8638
<211>  5628
<212>  DNA
<213>  Homosapiens

<400>  8638
cccgagtgtc ggttcactgt ggagacagcg gtggcggagt gggtctccag ggctctgggc     60

tggcaaggcc cccggagggg gtggggcgcg gaggaggcta cggatccgct tccgcgcggc    120

ggggccgggt gcttgggacg cggctctggg ctcccgggat aaggggctcc cgggacaagg    180

ggctcccgga gagcccagtg gttagcgatg ctgctgtcgc cgtcgctgct gctgctgctg    240

ctgctggggg cgccgcgggg ctgcgccgag ggtgtggcgg cggcgcttac ccccgagcgg    300

ctcctggagt ggcaggataa aggaatattt gttatccaaa gtgagagtct caagaaatgc    360

attcaagcag gtaaatcggt tctgaccctg gagaactgca agcaagcaaa caagcacatg    420

ctgtggaaat gggtttcaaa ccatggcctc tttaacatag gaggcagtgg ttgcctgggc    480

ctgaatttct ccgccccaga gcagccatta agcttatatg aatgtgactc caccctcgtt    540

tccttacggt ggcgctgtaa caggaagatg atcacaggcc cgctgcagta ctctgtccag    600

gtggcgcatg acaacacagt ggtggcctca cggaagtata ttcataagtg gatttcttat    660

gggtcaggtg gtggagacat ttgtgaatat ctacacaaag atttgcatac aatcaaaggg    720

aacacccacg ggatgccgtg tatgtttccc ttccagtata accatcagtg gcatcatgaa    780

tgtacccgtg aaggtcggga agatgactta ctgtggtgtg ccacgacaag ccgttatgaa    840

agagatgaaa agtggggatt ttgccctgat cccacctctg cagaagtagg ttgtgatact    900

atttgggaga aggacctcaa ttcacacatt tgctaccagt tcaacctgct ttcatctctc    960

tcttggagtg aggcacattc ttcatgccag atgcaaggag gtacgctgtt aagtattaca   1020

gatgaaactg aagaaaattt cataagggag cacatgagca gtaaaacagt ggaggtgtgg   1080

atgggcctca atcagctgga tgaacacgct ggctggcagt ggtctgatgg aacgccgctc   1140

aactatctga attggagccc agaggtaaat tttgagccat ttgttgaaga tcactgtgga   1200

acatttagtt catttatgcc aagtgcctgg aggagtcggg attgtgagtc caccttgcca   1260

tatatatgta aaaaatatct aaaccacatt gatcatgaaa tagttgaaaa agatgcgtgg   1320

aaatattatg ctacccactg tgagcctggc tggaatccct acaatcgtaa ttgctacaaa   1380

cttcagaaag aagaaaagac ctggcatgag gctctgcgtt cttgtcaggc tgataacagt   1440

gcattaatag acataacctc attagcagag gtggagtttc ttgtaaccct ccttggagat   1500

gaaaatgcat cagaaacatg gattggtttg agcagcaata aaattccagt ttcctttgaa   1560

tggtctaatg actcttcagt catctttact aattggcaca cacttgagcc ccacattttt   1620

ccaaatagaa gccagctgtg tgtctcagca gagcagtctg agggacactg gaaagtcaaa   1680

aattgtgaag aaagactttt ttacatttgt aaaaaagcag gccatgtcct ctctgatgct   1740

gaatcaggat gtcaagaggg atgggagaga catggtggat tctgttacaa aattgacaca   1800

gtccttcgaa gctttgacca agcttccagc ggttattact gtcctcctgc acttgtaacc   1860

attacaaaca ggtttgaaca ggcttttatt accagtttga tcagtagtgt ggtaaaaatg   1920

aaggacagtt atttttggat agctcttcag gaccaaaatg atacgggaga atacacttgg   1980

aagccagtag ggcagaaacc cgagccggtg cagtacacac actggaacac acaccagccg   2040

cgctacagtg gtggctgtgt tgccatgcga ggaaggcatc cacttggtcg ctgggaagtg   2100

aagcactgtc ggcactttaa ggcaatgtcc ttgtgcaagc agccagttga aaatcaggaa   2160

aaagcagagt atgaagagag atggcccttt cacccctgct atttggactg ggagtcagag   2220

cctggtctgg ccagttgctt caaggtattt catagtgaaa aagttctgat gaaaagaaca   2280

tggagagaag ctgaagcatt ttgcgaagaa tttggagctc atcttgcaag ctttgcccat   2340

attgaggaag agaattttgt gaatgagctc ttacattcaa aatttaattg gacagaagaa   2400

aggcagttct ggattggatt taataaaaga aacccactga atgccggctc atgggagtgg   2460

tctgatagaa ctcctgttgt ctcttcgttt ttagacaaca cttattttgg agaagatgca   2520

agaaactgtg ctgtttataa ggcaaacaaa acattgctgc ccttacactg tggttccaaa   2580

cgtgaatgga tatgcaaaat cccaagagat gtgaaaccca agattccgtt ctggtaccag   2640

tacgatgtac cctggctctt ttatcaggat gcagaatacc tttttcatac ctttgcctca   2700

gaatggttga actttgagtt tgtctgtagc tggctgcaca gtgatcttct cacaattcat   2760

tctgcacatg agcaagaatt catccacagc aaaataaaag cgctatcaaa gtatggtgca   2820

agttggtgga ttggacttca agaagaaaga gccaatgatg aatttcgctg gagagatgga   2880

acaccagtga tataccagaa ctgggacaca ggaagagaaa gaactgtgaa taatcagagc   2940

cagagatgtg gctttatttc ttctataaca ggactctggg gtagtgaaga gtgttcagtt   3000

tctatgccta gtatctgtaa gcgaaaaaag gtttggctca tagagaaaaa gaaagataca   3060

ccaaaacaac atggaacgtg tcccaaagga tggctatatt ttaactataa gtgccttctg   3120

ctgaatatcc ccaaagaccc aagcagttgg aagaactgga cgcatgctca acatttctgt   3180

gctgaagaag gggggaccct ggtcgccatt gaaagtgagg tggagcaagc tttcattact   3240

atgaatcttt ttggccagac caccagtgtg tggataggtt tacaaaatga tgattatgaa   3300

acatggctaa atggaaagcc tgtggtatat tctaactggt ctccatttga tataataaat   3360

attccaagtc acaataccac tgaagttcag aaacacattc ctctctgtgc cttactctca   3420

agtaatccta attttcattt cactggaaaa tggtattttg aagactgtgg aaaggaaggc   3480

tatgggtttg tttgtgaaaa aatgcaagat acttctggac acggtgtaaa tacatctgat   3540

atgtatccaa tgcccaatac cttagaatat ggaaacagaa cttacaaaat aattaatgca   3600

aatatgactt ggtatgcagc aataaaaacc tgcctgatgc acaaagcaca actggtcagc   3660

atcacagacc agtatcacca gtccttcctc actgttgtcc tcaaccggct aggatatgcc   3720

cactggattg gactgttcac cacagataat ggtcttaatt ttgactggtc tgatggcacc   3780

aaatcttctt tcactttttg gaaagatgag gagtcctccc tccttggtga ctgcgttttt   3840

gccgacagca acggacgctg gcatagcaca gcctgcgagt catttctgca aggtgccatt   3900

tgtcatgtgc cacctgaaac aagacaatct gaacacccag agttgtgctc agaaacatct   3960

attccctgga taaaatttaa aagtaattgc tacagttttt ctacagtcct agacagtatg   4020

agttttgagg ctgctcatga attttgcaaa aaggaaggtt ctaatctttt aacaatcaag   4080

gatgaggctg aaaatgcatt tctcctagaa gagctgtttg cttttggttc ttctgtccag   4140

atggtttggt tgaatgctca atttgatggt aacaatgaaa ccataaagtg gtttgatgga   4200

actcccacag accagtcaaa ctggggcatt cggaagccag acacagacta cttcaagccc   4260

catcattgtg ttgccttgag gatccctgaa ggattatggc agctatcccc gtgtcaagaa   4320

aaaaaaggct ttatatgtaa aatggaggca gatattcaca ctgcagaggc gctgccagaa   4380

aaaggaccaa gtcacagcat cattcctctt gcggttgtac tgacactgat agtcattgtg   4440

gccatttgca cactttcctt ctgcatatac aagcataacg gtggcttctt caggagactt   4500

gcagggtttc ggaatcctta ctatcctgca accaacttta gtacagtata tttagaagaa   4560

aatattctca tttctgatct tgagaagagt gaccaataat aatgaggtca gagaatgcca   4620

cagacaccag ggtaagtaaa gaagactaaa caggagtctc atctgtcttt ccctttacag   4680

cacagatgcc attagaatgt gaattgggtc actattttaa ttattcttga agtgattact   4740

ggttttgaat cttaaccaaa tcagatgggt tttgatttat tcatttccct aaactgtgat   4800

ccattcttaa aaggggtaaa ttatgcattg gttatttttc agaaagacaa gaactattaa   4860

aagaaactcc ctattgaaaa ctctgaaatc aatgcgaata atagtttttg cattaatgta   4920

tctctactaa aatttggggg aattttaaaa ctaatctggt atctattcag acatttacct   4980

gcactcgtac cattaagaaa gacagaaaga agcaaaaaaa aattaatctt gtatatgaga   5040

ggaaaaggaa agggcttctg agaggattct tagttgtttc ttttgaattc acttttaata   5100

gcaggatttg gaaaatacta atttctgtgc ttaagggtca caggttctgg gctctcaact   5160

gatatttaag gtgacattca tttttattag gtctaacatc tcaagctaaa ggagaaagaa   5220

aaataccttc ttttaaatgg caaagacctt cattagcagc acacttttat aaacaaccat   5280

atagttaaaa tgtggcctta aactttcaat tactaaatga tgattaagtt ggatatttta   5340

aaatgtctta tacataagct taaagtaata tattgaaact ttaacagttg tactgttaaa   5400

actcatggac tttctgaaaa actaaatata taaaataata tgtaacactc ttaataactg   5460

gaagatataa aatgtaactt ggatttaaag gagaagagct aaagatctga attatagtct   5520

cattagaacc agacagatgt tgttgagaag tactaaataa attagtaatc tagatatctt   5580

tattatgtaa atgagtttag gtgttctatt taataaacta ttttctgg                5628


<210>  8639
<211>  1463
<212>  PRT
<213>  Homosapiens

<400>  8639

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Asn 
    1310                 1315                 1320             


Glu Thr  Ile Lys Trp Phe Asp  Gly Thr Pro Thr Asp  Gln Ser Asn 
    1325                 1330                 1335             


Trp Gly  Ile Arg Lys Pro Asp  Thr Asp Tyr Phe Lys  Pro His His 
    1340                 1345                 1350             


Cys Val  Ala Leu Arg Ile Pro  Glu Gly Leu Trp Gln  Leu Ser Pro 
    1355                 1360                 1365             


Cys Gln  Glu Lys Lys Gly Phe  Ile Cys Lys Met Glu  Ala Asp Ile 
    1370                 1375                 1380             


His Thr  Ala Glu Ala Leu Pro  Glu Lys Gly Pro Ser  His Ser Ile 
    1385                 1390                 1395             


Ile Pro  Leu Ala Val Val Leu  Thr Leu Ile Val Ile  Val Ala Ile 
    1400                 1405                 1410             


Cys Thr  Leu Ser Phe Cys Ile  Tyr Lys His Asn Gly  Gly Phe Phe 
    1415                 1420                 1425             


Arg Arg  Leu Ala Gly Phe Arg  Asn Pro Tyr Tyr Pro  Ala Thr Asn 
    1430                 1435                 1440             


Phe Ser  Thr Val Tyr Leu Glu  Glu Asn Ile Leu Ile  Ser Asp Leu 
    1445                 1450                 1455             


Glu Lys  Ser Asp Gln 
    1460             


<210>  8640
<211>  5349
<212>  DNA
<213>  Homosapiens

<400>  8640
cccgagtgtc ggttcactgt ggagacagcg gtggcggagt gggtctccag ggctctgggc     60

tggcaaggcc cccggagggg gtggggcgcg gaggaggcta cggatccgct tccgcgcggc    120

ggggccgggt gcttgggacg cggctctggg ctcccgggat aaggggctcc cgggacaagg    180

ggctcccgga gagcccagtg gttagcgatg ctgctgtcgc cgtcgctgct gctgctgctg    240

ctgctggggg cgccgcgggg ctgcgccgag ggtgtggcgg cggcgcttac ccccgagcgg    300

ctcctggagt ggcaggataa aggaatattt gttatccaaa gtgagagtct caagaaatgc    360

attcaagcag gtaaatcggt tctgaccctg gagaactgca agcaagcaaa caagcacatg    420

ctgtggaaat gggtttcaaa ccatggcctc tttaacatag gaggcagtgg ttgcctgggc    480

ctgaatttct ccgccccaga gcagccatta agcttatatg aatgtgactc caccctcgtt    540

tccttacggt ggcgctgtaa caggaagatg atcacaggcc cgctgcagta ctctgtccag    600

gtggcgcatg acaacacagt ggtggcctca cggaagtata ttcataagtg gatttcttat    660

gggtcaggtg gtggagacat ttgtgaatat ctacacaaag atttgcatac aatcaaaggg    720

aacacccacg ggatgccgtg tatgtttccc ttccagtata accatcagtg gcatcatgaa    780

tgtacccgtg aaggtcggga agatgactta ctgtggtgtg ccacgacaag ccgttatgaa    840

agagatgaaa agtggggatt ttgccctgat cccacctctg cagaagtagg ttgtgatact    900

atttgggaga aggacctcaa ttcacacatt tgctaccagt tcaacctgct ttcatctctc    960

tcttggagtg aggcacattc ttcatgccag atgcaaggag gtacgctgtt aagtattaca   1020

gatgaaactg aagaaaattt cataagggag cacatgagca gtaaaacagt ggaggtgtgg   1080

atgggcctca atcagctgga tgaacacgct ggctggcagt ggtctgatgg aacgccgctc   1140

aactatctga attggagccc agaggtaaat tttgagccat ttgttgaaga tcactgtgga   1200

acatttagtt catttatgcc aagtgcctgg aggagtcggg attgtgagtc caccttgcca   1260

tatatatgta aaaaatatct aaaccacatt gatcatgaaa tagttgaaaa agatgcgtgg   1320

aaatattatg ctacccactg tgagcctggc tggaatccct acaatcgtaa ttgctacaaa   1380

cttcagaaag aagaaaagac ctggcatgag gctctgcgtt cttgtcaggc tgataacagt   1440

gcattaatag acataacctc attagcagag gtggagtttc ttgtaaccct ccttggagat   1500

gaaaatgcat cagaaacatg gattggtttg agcagcaata aaattccagt ttcctttgaa   1560

tggtctaatg actcttcagt catctttact aattggcaca cacttgagcc ccacattttt   1620

ccaaatagaa gccagctgtg tgtctcagca gagcagtctg agggacactg gaaagtcaaa   1680

aattgtgaag aaagactttt ttacatttgt aaaaaagcag gccatgtcct ctctgatgct   1740

gaatcaggat gtcaagaggg atgggagaga catggtggat tctgttacaa aattgacaca   1800

gtccttcgaa gctttgacca agcttccagc ggttattact gtcctcctgc acttgtaacc   1860

attacaaaca ggtttgaaca ggcttttatt accagtttga tcagtagtgt ggtaaaaatg   1920

aaggacagtt atttttggat agctcttcag gaccaaaatg atacgggaga atacacttgg   1980

aagccagtag ggcagaaacc cgagccggtg cagtacacac actggaacac acaccagccg   2040

cgctacagtg gtggctgtgt tgccatgcga ggaaggcatc cacttggtcg ctgggaagtg   2100

aagcactgtc ggcactttaa ggcaatgtcc ttgtgcaagc agccagttga aaatcaggaa   2160

aaagcagagt atgaagagag atggcccttt cacccctgct atttggactg ggagtcagag   2220

cctggtctgg ccagttgctt caaggtattt catagtgaaa aagttctgat gaaaagaaca   2280

tggagagaag ctgaagcatt ttgcgaagaa tttggagctc atcttgcaag ctttgcccat   2340

attgaggaag agaattttgt gaatgagctc ttacattcaa aatttaattg gacagaagaa   2400

aggcagttct ggattggatt taataaaaga aacccactga atgccggctc atgggagtgg   2460

tctgatagaa ctcctgttgt ctcttcgttt ttagacaaca cttattttgg agaagatgca   2520

agaaactgtg ctgtttataa ggcaaacaaa acattgctgc ccttacactg tggttccaaa   2580

cgtgaatgga tatgcaaaat cccaagagat gtgaaaccca agattccgtt ctggtaccag   2640

tacgatgtac cctggctctt ttatcaggat gcagaatacc tttttcatac ctttgcctca   2700

gaatggttga actttgagtt tgtctgtagc tggctgcaca gtgatcttct cacaattcat   2760

tctgcacatg agcaagaatt catccacagc aaaataaaag cgctatcaaa gtatggtgca   2820

agttggtgga ttggacttca agaagaaaga gccaatgatg aatttcgctg gagagatgga   2880

acaccagtga tataccagaa ctgggacaca ggaagagaaa gaactgtgaa taatcagagc   2940

cagagatgtg gctttatttc ttctataaca ggactctggg gtagtgaaga gtgttcagtt   3000

tctatgccta gtatctgtaa gcgaaaaaag gtttggctca tagagaaaaa gaaagataca   3060

ccaaaacaac atggaacgtg tcccaaagga tggctatatt ttaactataa gtgccttctg   3120

ctgaatatcc ccaaagaccc aagcagttgg aagaactgga cgcatgctca acatttctgt   3180

gctgaagaag gggggaccct ggtcgccatt gaaagtgagg tggagcaagc tttcattact   3240

atgaatcttt ttggccagac caccagtgtg tggataggtt tacaaaatga tgattatgaa   3300

acatggctaa atggaaagcc tgtggtatat tctaactggt ctccatttga tataataaat   3360

attccaagtc acaataccac tgaagttcag aaacacattc ctctctgtgc cttactctca   3420

agtaatccta attttcattt cactggaaaa tggtattttg aagactgtgg aaaggaaggc   3480

tatgggtttg tttgtgaaaa aatgcaagat acttctggac acggtgtaaa tacatctgat   3540

atgtatccaa tgcccaatac cttagaatat ggaaacagaa cttacaaaat aattaatgca   3600

aatatgactt ggtatgcagc aataaaaacc tgcctgatgc acaaagcaca actggtcagc   3660

atcacagacc agtatcacca gtccttcctc actgttgtcc tcaaccggct aggatatgcc   3720

cactggattg gactgttcac cacagataat ggtcttaatt ttgactggtc tgatggcacc   3780

aaatcttctt tcactttttg gaaagatgag gagtcctccc tccttggtga ctgcgttttt   3840

gccgacagca acggacgctg gcatagcaca gcctgcgagt catttctgca aggtgccatt   3900

tgtcatgtgc cacctgaaac aagacaatct gaacacccag agttgtgctc agaaacatct   3960

attccctgga taaaatttaa aagtaattgc tacagttttt ctacagtcct agacagtatg   4020

agttttgagg ctgctcatga attttgcaaa aaggaaggtt ctaatctttt aacaatcaag   4080

gatgaggctg aaaatgcatt tctcctagaa gagctgtttg cttttggttc ttctgtccag   4140

atggtttggt tgaatgctca atttgatggt aacagtaagt gatttgggta gaggagagga   4200

cataaataaa tacatggttg ttaaagctga tgataatggc atctgtgagc cagaaaactc   4260

tccttggata cgttttctga gaaaaaatag catgaagcct aaagccattt cttccaaaaa   4320

caacattgca acccttttct ttaccctttt gtcttttaaa ataatcccag aacaccaaaa   4380

ataaaaacaa acaataacat gtttatcttt acccttagca ggaagatgct tggctggaac   4440

tttgtgttca cagacttagt cattgcatac caaaaccata tttactggaa aatatcccag   4500

gtttctaaat gttataaaag cacaatagag ttatggaaat gtttccatga tgaactgtgc   4560

tgttaggatt cttatttgct actcataaaa accagagttt gtaataaaat ggaagcatgg   4620

tattcttttc tttatgtaat tgatggttat tgaaaggtac ttgtgaagaa aattatttta   4680

attggtatgg agagcttgtt acagtggtgt accaaggttg ggggtgagcc taccctttcg   4740

aggaggagta ttttaatcac caacattgtt tagaatttca agcagatggt gataataaaa   4800

agcagaccaa cttttagtta gctgtattgt tagttttaaa ttattttcag acaatacact   4860

attgcccaca catgggatgg actctcctac cgcccctacc cccttggtac atggctggct   4920

tggtattaaa gaaattcact gtaaaatctt tttagaaagt gagccatttt gtaatgatga   4980

agatgttagg acttcaaagg atttttcttt actcgattag ttttgtttat caaatgattt   5040

ctttaaatcg attatatata tatatggaat atttcaaaat tcaaactgtc acattaagaa   5100

acatgataac ctaaatgacc taaataagaa cactgtacct aaaataaaga ggcaacttta   5160

ttaatgccta ccttttgatg ttgagtacat cactgtattt actgagttga atgtattagt   5220

tcaagagtct cattaaattc aggggctgcc atcccattac tgggtatata cccaaaggac   5280

tataaatcat gctgctataa agacacatac acacgtatgt ttattgcggc actattcaca   5340

atagcaaag                                                           5349


<210>  8641
<211>  1324
<212>  PRT
<213>  Homosapiens

<400>  8641

Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Ala Pro 
1               5                   10                  15      


Arg Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu 
            20                  25                  30          


Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu 
        35                  40                  45              


Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys 
    50                  55                  60                  


Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn His Gly 
65                  70                  75                  80  


Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe Ser Ala 
                85                  90                  95      


Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu Val Ser 
            100                 105                 110         


Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu Gln Tyr 
        115                 120                 125             


Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg Lys Tyr 
    130                 135                 140                 


Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile Cys Glu 
145                 150                 155                 160 


Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His Gly Met 
                165                 170                 175     


Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His Glu Cys 
            180                 185                 190         


Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr Thr Ser 
        195                 200                 205             


Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro Thr Ser 
    210                 215                 220                 


Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn Ser His 
225                 230                 235                 240 


Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser Glu Ala 
                245                 250                 255     


His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile Thr Asp 
            260                 265                 270         


Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys Thr Val 
        275                 280                 285             


Glu Val Trp Met Gly Leu Asn Gln Leu Asp Glu His Ala Gly Trp Gln 
    290                 295                 300                 


Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro Glu Val 
305                 310                 315                 320 


Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser Ser Phe 
                325                 330                 335     


Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu Pro Tyr 
            340                 345                 350         


Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val Glu Lys 
        355                 360                 365             


Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp Asn Pro 
    370                 375                 380                 


Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr Trp His 
385                 390                 395                 400 


Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile Asp Ile 
                405                 410                 415     


Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly Asp Glu 
            420                 425                 430         


Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile Pro Val 
        435                 440                 445             


Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn Trp His 
    450                 455                 460                 


Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys Val Ser 
465                 470                 475                 480 


Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu Glu Arg 
                485                 490                 495     


Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp Ala Glu 
            500                 505                 510         


Ser Gly Cys Gln Glu Gly Trp Glu Arg His Gly Gly Phe Cys Tyr Lys 
        515                 520                 525             


Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly Tyr Tyr 
    530                 535                 540                 


Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln Ala Phe 
545                 550                 555                 560 


Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser Tyr Phe 
                565                 570                 575     


Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr Trp Lys 
            580                 585                 590         


Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp Asn Thr 
        595                 600                 605             


His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly Arg His 
    610                 615                 620                 


Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys Ala Met 
625                 630                 635                 640 


Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu Tyr Glu 
                645                 650                 655     


Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser Glu Pro 
            660                 665                 670         


Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val Leu Met 
        675                 680                 685             


Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe Gly Ala 
    690                 695                 700                 


His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val Asn Glu 
705                 710                 715                 720 


Leu Leu His Ser Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe Trp Ile 
                725                 730                 735     


Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu Trp Ser 
            740                 745                 750         


Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr Phe Gly 
        755                 760                 765             


Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Ala Asn Lys Thr Leu Leu 
    770                 775                 780                 


Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile Pro Arg 
785                 790                 795                 800 


Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val Pro Trp 
                805                 810                 815     


Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala Ser Glu 
            820                 825                 830         


Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp Leu Leu 
        835                 840                 845             


Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys Ile Lys 
    850                 855                 860                 


Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln Glu Glu 
865                 870                 875                 880 


Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val Ile Tyr 
                885                 890                 895     


Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln Ser Gln 
            900                 905                 910         


Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser Glu Glu 
        915                 920                 925             


Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val Trp Leu 
    930                 935                 940                 


Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys Pro Lys 
945                 950                 955                 960 


Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile Pro Lys 
                965                 970                 975     


Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe Cys Ala 
            980                 985                 990         


Glu Glu Gly Gly Thr Leu Val Ala  Ile Glu Ser Glu Val  Glu Gln Ala 
        995                 1000                 1005             


Phe Ile  Thr Met Asn Leu Phe  Gly Gln Thr Thr Ser  Val Trp Ile 
    1010                 1015                 1020             


Gly Leu  Gln Asn Asp Asp Tyr  Glu Thr Trp Leu Asn  Gly Lys Pro 
    1025                 1030                 1035             


Val Val  Tyr Ser Asn Trp Ser  Pro Phe Asp Ile Ile  Asn Ile Pro 
    1040                 1045                 1050             


Ser His  Asn Thr Thr Glu Val  Gln Lys His Ile Pro  Leu Cys Ala 
    1055                 1060                 1065             


Leu Leu  Ser Ser Asn Pro Asn  Phe His Phe Thr Gly  Lys Trp Tyr 
    1070                 1075                 1080             


Phe Glu  Asp Cys Gly Lys Glu  Gly Tyr Gly Phe Val  Cys Glu Lys 
    1085                 1090                 1095             


Met Gln  Asp Thr Ser Gly His  Gly Val Asn Thr Ser  Asp Met Tyr 
    1100                 1105                 1110             


Pro Met  Pro Asn Thr Leu Glu  Tyr Gly Asn Arg Thr  Tyr Lys Ile 
    1115                 1120                 1125             


Ile Asn  Ala Asn Met Thr Trp  Tyr Ala Ala Ile Lys  Thr Cys Leu 
    1130                 1135                 1140             


Met His  Lys Ala Gln Leu Val  Ser Ile Thr Asp Gln  Tyr His Gln 
    1145                 1150                 1155             


Ser Phe  Leu Thr Val Val Leu  Asn Arg Leu Gly Tyr  Ala His Trp 
    1160                 1165                 1170             


Ile Gly  Leu Phe Thr Thr Asp  Asn Gly Leu Asn Phe  Asp Trp Ser 
    1175                 1180                 1185             


Asp Gly  Thr Lys Ser Ser Phe  Thr Phe Trp Lys Asp  Glu Glu Ser 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Cys Val  Phe Ala Asp Ser Asn  Gly Arg Trp 
    1205                 1210                 1215             


His Ser  Thr Ala Cys Glu Ser  Phe Leu Gln Gly Ala  Ile Cys His 
    1220                 1225                 1230             


Val Pro  Pro Glu Thr Arg Gln  Ser Glu His Pro Glu  Leu Cys Ser 
    1235                 1240                 1245             


Glu Thr  Ser Ile Pro Trp Ile  Lys Phe Lys Ser Asn  Cys Tyr Ser 
    1250                 1255                 1260             


Phe Ser  Thr Val Leu Asp Ser  Met Ser Phe Glu Ala  Ala His Glu 
    1265                 1270                 1275             


Phe Cys  Lys Lys Glu Gly Ser  Asn Leu Leu Thr Ile  Lys Asp Glu 
    1280                 1285                 1290             


Ala Glu  Asn Ala Phe Leu Leu  Glu Glu Leu Phe Ala  Phe Gly Ser 
    1295                 1300                 1305             


Ser Val  Gln Met Val Trp Leu  Asn Ala Gln Phe Asp  Gly Asn Ser 
    1310                 1315                 1320             


Lys 
    


<210>  8642
<211>  671
<212>  DNA
<213>  Homosapiens

<400>  8642
aggtttgaac aggcttttat taccagtttg atcagtagtg tggtaaaaat gaaggacagt     60

tatttttgga tagctcttca ggaccaaaat gatacgggag aatacacttg gaagccagta    120

gggcagaaac ccgagccggt gcagtacaca cactggaaca cacaccagcc gcgctacagt    180

ggtggctgtg ttgccatgcg aggaaggcat ccacttggtc gctgggaagt gaagcactgt    240

cggcacttta aggcaatgtc cttgtgcaag cagccagttg aaaatcagga aaaagcagag    300

tatgaagaga gatggccctt tcacccctgc tatttggact gggagtcaga gcctggtctg    360

gccagttgct tcaaggtatt tcatagtgaa aaagttctga tgaaaagaac atggagagaa    420

gctgaagcat tttgcgaaga atttggagct catcttgcaa gctttgccca tattgaggaa    480

gagaattttg tgaatgagct cttacattca aaatttaatt ggtaaatact tgttaattat    540

gaaaaattac agtcaaatat tctatctccc agtaatggct tctgaggggt gagtatccca    600

agtagttgtt taaaattccc atatttgtat tatgcccaaa gccaagaaaa ataaatatac    660

atatagtttt a                                                         671


<210>  8643
<211>  158
<212>  PRT
<213>  Homosapiens

<400>  8643

Met Lys Asp Ser Tyr Phe Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr 
1               5                   10                  15      


Gly Glu Tyr Thr Trp Lys Pro Val Gly Gln Lys Pro Glu Pro Val Gln 
            20                  25                  30          


Tyr Thr His Trp Asn Thr His Gln Pro Arg Tyr Ser Gly Gly Cys Val 
        35                  40                  45              


Ala Met Arg Gly Arg His Pro Leu Gly Arg Trp Glu Val Lys His Cys 
    50                  55                  60                  


Arg His Phe Lys Ala Met Ser Leu Cys Lys Gln Pro Val Glu Asn Gln 
65                  70                  75                  80  


Glu Lys Ala Glu Tyr Glu Glu Arg Trp Pro Phe His Pro Cys Tyr Leu 
                85                  90                  95      


Asp Trp Glu Ser Glu Pro Gly Leu Ala Ser Cys Phe Lys Val Phe His 
            100                 105                 110         


Ser Glu Lys Val Leu Met Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe 
        115                 120                 125             


Cys Glu Glu Phe Gly Ala His Leu Ala Ser Phe Ala His Ile Glu Glu 
    130                 135                 140                 


Glu Asn Phe Val Asn Glu Leu Leu His Ser Lys Phe Asn Trp 
145                 150                 155             


<210>  8644
<211>  2532
<212>  DNA
<213>  Homosapiens

<400>  8644
gcgcatgcag cccttcccaa gcactggtag ggcactgggc atgcagacag cccaccagaa     60

gggaagaatc aggagaaaag ggatgcaaga tcccagagat aaactgaagc acaagagggt    120

aaaaactttg tccttggtct tacagccaga aagtggtgat gcaaagaact tagtccaagc    180

tttgatctgt tctgcactgc ctgccaaagc agaaccttga gaaataccca tgtttggggg    240

atgagaagaa gaagataaat cagcaaagaa aatagtgata agaaagatgc agaacccagg    300

gatatggaga gccaattgta tttgtaaaac acttagaatg gtgcctgaca cgtgagttgc    360

tttgtctaat tctagccctg tggtagctac ccaagattgt tgtaacctcc agtgatcaag    420

ttctttggat aagcaaagag ggagggcatt aagtgtgtgg aaaagacccc tcctctccac    480

tcttgttgca aggactcagg atcctgccct ctgagggttt acagaagtca ttctcactat    540

ctcacactgg ccgtcttgac ccagagcagt tctttacttt ctcgggacac aaacgggatg    600

aaagtccagg gctgggactt cctccttgga atgtttgaca aggactgacg tactctaggc    660

cctttgaatc ccggaagtcc aggacacacc caaccttgat tacagtgtcc agaatgctgg    720

agcgtaggtg aaaggacaaa agccagacac atttcaacat gagggaccca ctgacagatt    780

gtccgtataa taaagtatac aagaacctaa aggagttttc tcaaaatgga gagaatttct    840

gcaaacaggt cacatctgtt cttcagcaaa gggcaaacct ggaaattagc tatgccaaag    900

gacttcagaa actggcaagc aagctgagca aagcattaca gaacacgaga aaaagttgtg    960

ttagcagtgc ctgggcctgg gcctcagagg gaatgaaatc cacagcggac ctgcatcaaa   1020

aacttggcaa agcaattgaa ttggaagcaa taaaaccgac ttatcaagtc ctaaatgtac   1080

aagagaagaa gagaaaatca cttgacaatg aagttgaaaa gacagcaaat cttgtcatta   1140

gcaactggaa tcagcaaatt aaggcaaaag aaattaatgg ttagtaccaa gaaacatgaa   1200

gcacttttcc agcttgtaga aagctccaag caatctatga ctgagaagga gaagcggaag   1260

ctcctcaata aactgacaaa atcaactgaa aagttggaaa aggaagatga aaattactac   1320

caaaaaaaca tggcgggtta ttctaccaga ctgaaatggg aaaacacact agagaactgc   1380

taccaggtaa cccacagcat ctgcctatat gccttttggg tcaaaagagc ctggggaaag   1440

tgtgtgagtg atttaagata ccaagacaca ttccttcctg gaaatctccc tccactatgg   1500

tttggatatg acatagtcaa gaggctaatc atgagacttt gttcagtctg tcttcagagc   1560

attctggagc tggagaagga aagaattcaa cttttatgca ataacttaaa ccagtacagc   1620

caacatattt ctctttttgg ccaaaccctg accacatgcc acacgcagat tcactgtgcc   1680

atcagcaaga ttgacattga aaaagatatc caggctgtaa tggaagaaac tgcaatttta   1740

tctacagaaa acaaatctga gttcctgtta acggattact ttgaagaaga tcctaacagt   1800

gcaatggata aagagagacg aaagtcttta ctaaaaccaa aattattgag actgcagaga   1860

gacattgaaa aagcctcaaa agacaaggaa ggcctggaac gaatgcttaa aacgtactcc   1920

agcacctcct ccttctctga tgcaaagagc cagaaagaca cagcagcgtt aatggatgag   1980

aacaatttga aactagacct tttggaagcg aactcctaca aactgtcatc aatgttagca   2040

gaacttgagc aaagacctca acccagccat ccttgtagta attccatctt caggtggagg   2100

gaaaaggagc atactcatag ctatgtgaaa atatctcggc cttttttaat gaagagatta   2160

gagaatattg tgagcaaggc atcttctggt gggcagagca atccaggttc ttcaactcca   2220

gcccctggtg cagcccagct cagcagcaga ctttgcaagg ccttgtattc ttttcaagcc   2280

aggcaagatg atgagttgaa tttggaaaag ggtgacattg tgattataca cgagaaaaaa   2340

gaaggaggat ggtggtttgg atctttgaat gggaaaaaag gccattttcc tgccgcttat   2400

gtggaggagt taccttcaaa tgctggcaac acagctacaa aggcataaaa caagactctg   2460

aacatactac cttcacactc ggtaatcaac aatacagtgt ggttcaaata agaataaagt   2520

gctcttacct tt                                                       2532


<210>  8645
<211>  457
<212>  PRT
<213>  Homosapiens

<400>  8645

Met Tyr Lys Arg Arg Arg Glu Asn His Leu Thr Met Lys Leu Lys Arg 
1               5                   10                  15      


Gln Gln Ile Leu Ser Leu Ala Thr Gly Ile Ser Lys Leu Arg Gln Lys 
            20                  25                  30          


Lys Leu Met Val Ser Thr Lys Lys His Glu Ala Leu Phe Gln Leu Val 
        35                  40                  45              


Glu Ser Ser Lys Gln Ser Met Thr Glu Lys Glu Lys Arg Lys Leu Leu 
    50                  55                  60                  


Asn Lys Leu Thr Lys Ser Thr Glu Lys Leu Glu Lys Glu Asp Glu Asn 
65                  70                  75                  80  


Tyr Tyr Gln Lys Asn Met Ala Gly Tyr Ser Thr Arg Leu Lys Trp Glu 
                85                  90                  95      


Asn Thr Leu Glu Asn Cys Tyr Gln Val Thr His Ser Ile Cys Leu Tyr 
            100                 105                 110         


Ala Phe Trp Val Lys Arg Ala Trp Gly Lys Cys Val Ser Asp Leu Arg 
        115                 120                 125             


Tyr Gln Asp Thr Phe Leu Pro Gly Asn Leu Pro Pro Leu Trp Phe Gly 
    130                 135                 140                 


Tyr Asp Ile Val Lys Arg Leu Ile Met Arg Leu Cys Ser Val Cys Leu 
145                 150                 155                 160 


Gln Ser Ile Leu Glu Leu Glu Lys Glu Arg Ile Gln Leu Leu Cys Asn 
                165                 170                 175     


Asn Leu Asn Gln Tyr Ser Gln His Ile Ser Leu Phe Gly Gln Thr Leu 
            180                 185                 190         


Thr Thr Cys His Thr Gln Ile His Cys Ala Ile Ser Lys Ile Asp Ile 
        195                 200                 205             


Glu Lys Asp Ile Gln Ala Val Met Glu Glu Thr Ala Ile Leu Ser Thr 
    210                 215                 220                 


Glu Asn Lys Ser Glu Phe Leu Leu Thr Asp Tyr Phe Glu Glu Asp Pro 
225                 230                 235                 240 


Asn Ser Ala Met Asp Lys Glu Arg Arg Lys Ser Leu Leu Lys Pro Lys 
                245                 250                 255     


Leu Leu Arg Leu Gln Arg Asp Ile Glu Lys Ala Ser Lys Asp Lys Glu 
            260                 265                 270         


Gly Leu Glu Arg Met Leu Lys Thr Tyr Ser Ser Thr Ser Ser Phe Ser 
        275                 280                 285             


Asp Ala Lys Ser Gln Lys Asp Thr Ala Ala Leu Met Asp Glu Asn Asn 
    290                 295                 300                 


Leu Lys Leu Asp Leu Leu Glu Ala Asn Ser Tyr Lys Leu Ser Ser Met 
305                 310                 315                 320 


Leu Ala Glu Leu Glu Gln Arg Pro Gln Pro Ser His Pro Cys Ser Asn 
                325                 330                 335     


Ser Ile Phe Arg Trp Arg Glu Lys Glu His Thr His Ser Tyr Val Lys 
            340                 345                 350         


Ile Ser Arg Pro Phe Leu Met Lys Arg Leu Glu Asn Ile Val Ser Lys 
        355                 360                 365             


Ala Ser Ser Gly Gly Gln Ser Asn Pro Gly Ser Ser Thr Pro Ala Pro 
    370                 375                 380                 


Gly Ala Ala Gln Leu Ser Ser Arg Leu Cys Lys Ala Leu Tyr Ser Phe 
385                 390                 395                 400 


Gln Ala Arg Gln Asp Asp Glu Leu Asn Leu Glu Lys Gly Asp Ile Val 
                405                 410                 415     


Ile Ile His Glu Lys Lys Glu Gly Gly Trp Trp Phe Gly Ser Leu Asn 
            420                 425                 430         


Gly Lys Lys Gly His Phe Pro Ala Ala Tyr Val Glu Glu Leu Pro Ser 
        435                 440                 445             


Asn Ala Gly Asn Thr Ala Thr Lys Ala 
    450                 455         


<210>  8646
<211>  2977
<212>  DNA
<213>  Homosapiens

<400>  8646
gcgcatgcag cccttcccaa gcactggtag ggcactgggc atgcagacag cccaccagaa     60

gggaagaatc aggagaaaag ggatgcaaga tcccagagat aaactgaagc acaagagggt    120

aaaaactttg tccttggtct tacagccaga aagtggtgat gcaaagaact tagtccaagc    180

tttgatctgt tctgcactgc ctgccaaagc agaaccttga gaaataccca tgtttggggg    240

atgagaagaa gaagataaat cagcaaagaa aatagtgata agaaagatgc agaacccagg    300

gatatggaga gccaattgta tttgtaaaac acttagaatg gtgcctgaca cgtgagttgc    360

tttgtctaat tctagccctg tggtagctac ccaagattgt tgtaacctcc agtgatcaag    420

ttctttggat aagcaaagag ggagggcatt aagtgtgtgg aaaagacccc tcctctccac    480

tcttgttgca aggactcagg atcctgccct ctgagggttt acagaagtca ttctcactat    540

ctcacactgg ccgtcttgac ccagagcagt tctttacttt ctcgggacac aaacgggatg    600

aaagtccagg gctgggactt cctccttgga atgtttgaca aggactgacg tactctaggc    660

cctttgaatc ccggaagtcc aggacacacc caaccttgat tacagtgtcc agaatgctgg    720

agcgtaggtg aaaggacaaa agccagacac atttcaacat gagggaccca ctgacagatt    780

gtccgtataa taaagtatac aagaacctaa aggagttttc tcaaaatgga gagaatttct    840

gcaaacaggt cacatctgtt cttcagcaaa gggcaaacct ggaaattagc tatgccaaag    900

gacttcagaa actggcaagc aagctgagca aagcattaca gaacacgaga aaaagttgtg    960

ttagcagtgc ctgggcctgg gcctcagagg gaatgaaatc cacagcggac ctgcatcaaa   1020

aacttggcaa agcaattgaa ttggaagcaa taaaaccgac ttatcaagtc ctaaatgtac   1080

aagagaagaa gagaaaatca cttgacaatg aagttgaaaa gacagcaaat cttgtcatta   1140

gcaactggaa tcagcaaatt aaggcaaaag aaattaatgg ttagtaccaa gaaacatgaa   1200

gcacttttcc agcttgtaga aagctccaag caatctatga ctgagaagga gaagcggaag   1260

ctcctcaata aactgacaaa atcaactgaa aagttggaaa aggaagatga aaattactac   1320

caaaaaaaca tggcgggtta ttctaccaga ctgaaatggg aaaacacact agagaactgc   1380

taccaggtaa cccacagcat ctgcctatat gccttttggg tcaaaagagc ctggggaaag   1440

tgtgtgagtg atttaagata ccaagacaca ttccttcctg gaaatctccc tccactatgg   1500

tttggatatg acatagtcaa gaggctaatc atgagacttt gttcagtctg tcttcagagc   1560

attctggagc tggagaagga aagaattcaa cttttatgca ataacttaaa ccagtacagc   1620

caacatattt ctctttttgg ccaaaccctg accacatgcc acacgcagat tcactgtgcc   1680

atcagcaaga ttgacattga aaaagatatc caggctgtaa tggaagaaac tgcaatttta   1740

tctacagaaa acaaatctga gttcctgtta acggattact ttgaagaaga tcctaacagt   1800

gcaatggata aagagagacg aaagtcttta ctaaaaccaa aattattgag actgcagaga   1860

gacattgaaa aagcctcaaa agacaaggaa ggcctggaac gaatgcttaa aacgtactcc   1920

agcacctcct ccttctctga tgcaaagagc cagaaagaca cagcagcgtt aatggatgag   1980

aacaatttga aactagacct tttggaagcg aactcctaca aactgtcatc aatgttagca   2040

gaacttgagc aaagacctca acccagccat ccttgtagta attccatctt caggtggagg   2100

gaaaaggagc atactcatag ctatgtgaaa atatctcggc cttttttaat gaagagatta   2160

gagaatattg tgagcaaggc atcttctggt gggcagagca atccaggttc ttcaactcca   2220

gcccctggtg cagcccagct cagcagcaga ctttgcaagg ccttgtattc ttttcaagcc   2280

aggcaagatg atgagttgaa tttggaaaag ggtgacattg tgattataca cgagaaaaaa   2340

gaaggaggat ggtggtttgg atctttgaat gggaaaaaag gccattttcc tgccgcttat   2400

gtggaggagt taccttcaaa tgctggcaac acagctacaa aggcataaaa caagactctg   2460

aacatactac cttcacactc ggtaatcaac aatacagtgt ggttcaaata agaataaagt   2520

gctcttacct ttacatgttt ttcttttgaa atggatggag ttctacctgc atgtcacagc   2580

actttgcatt catgattatt agcttgaaac agtcagaaaa aagatggatg ggtggagaca   2640

gacaaggaag aggctccttg gttcctagag gagtttccaa attctaggag accctagaga   2700

tgatccagta taacccctgg tgtcacagaa acagacggag tccaaggtgg gttcagctgc   2760

ttgcctgaag tcagagttat ctggtagaca acagcagtgg gacttagatg tctttttcct   2820

ctggatttgg gtggcaacag aacacagcag gcctatgagg gggtcaagca gagcctggga   2880

gatgaggaac acagatcaat tccaagaaga gagacaggca atcaagacac caatgagatc   2940

aacccaaatt aggggatggt aggatatctc tgacaaa                            2977


<210>  8647
<211>  457
<212>  PRT
<213>  Homosapiens

<400>  8647

Met Tyr Lys Arg Arg Arg Glu Asn His Leu Thr Met Lys Leu Lys Arg 
1               5                   10                  15      


Gln Gln Ile Leu Ser Leu Ala Thr Gly Ile Ser Lys Leu Arg Gln Lys 
            20                  25                  30          


Lys Leu Met Val Ser Thr Lys Lys His Glu Ala Leu Phe Gln Leu Val 
        35                  40                  45              


Glu Ser Ser Lys Gln Ser Met Thr Glu Lys Glu Lys Arg Lys Leu Leu 
    50                  55                  60                  


Asn Lys Leu Thr Lys Ser Thr Glu Lys Leu Glu Lys Glu Asp Glu Asn 
65                  70                  75                  80  


Tyr Tyr Gln Lys Asn Met Ala Gly Tyr Ser Thr Arg Leu Lys Trp Glu 
                85                  90                  95      


Asn Thr Leu Glu Asn Cys Tyr Gln Val Thr His Ser Ile Cys Leu Tyr 
            100                 105                 110         


Ala Phe Trp Val Lys Arg Ala Trp Gly Lys Cys Val Ser Asp Leu Arg 
        115                 120                 125             


Tyr Gln Asp Thr Phe Leu Pro Gly Asn Leu Pro Pro Leu Trp Phe Gly 
    130                 135                 140                 


Tyr Asp Ile Val Lys Arg Leu Ile Met Arg Leu Cys Ser Val Cys Leu 
145                 150                 155                 160 


Gln Ser Ile Leu Glu Leu Glu Lys Glu Arg Ile Gln Leu Leu Cys Asn 
                165                 170                 175     


Asn Leu Asn Gln Tyr Ser Gln His Ile Ser Leu Phe Gly Gln Thr Leu 
            180                 185                 190         


Thr Thr Cys His Thr Gln Ile His Cys Ala Ile Ser Lys Ile Asp Ile 
        195                 200                 205             


Glu Lys Asp Ile Gln Ala Val Met Glu Glu Thr Ala Ile Leu Ser Thr 
    210                 215                 220                 


Glu Asn Lys Ser Glu Phe Leu Leu Thr Asp Tyr Phe Glu Glu Asp Pro 
225                 230                 235                 240 


Asn Ser Ala Met Asp Lys Glu Arg Arg Lys Ser Leu Leu Lys Pro Lys 
                245                 250                 255     


Leu Leu Arg Leu Gln Arg Asp Ile Glu Lys Ala Ser Lys Asp Lys Glu 
            260                 265                 270         


Gly Leu Glu Arg Met Leu Lys Thr Tyr Ser Ser Thr Ser Ser Phe Ser 
        275                 280                 285             


Asp Ala Lys Ser Gln Lys Asp Thr Ala Ala Leu Met Asp Glu Asn Asn 
    290                 295                 300                 


Leu Lys Leu Asp Leu Leu Glu Ala Asn Ser Tyr Lys Leu Ser Ser Met 
305                 310                 315                 320 


Leu Ala Glu Leu Glu Gln Arg Pro Gln Pro Ser His Pro Cys Ser Asn 
                325                 330                 335     


Ser Ile Phe Arg Trp Arg Glu Lys Glu His Thr His Ser Tyr Val Lys 
            340                 345                 350         


Ile Ser Arg Pro Phe Leu Met Lys Arg Leu Glu Asn Ile Val Ser Lys 
        355                 360                 365             


Ala Ser Ser Gly Gly Gln Ser Asn Pro Gly Ser Ser Thr Pro Ala Pro 
    370                 375                 380                 


Gly Ala Ala Gln Leu Ser Ser Arg Leu Cys Lys Ala Leu Tyr Ser Phe 
385                 390                 395                 400 


Gln Ala Arg Gln Asp Asp Glu Leu Asn Leu Glu Lys Gly Asp Ile Val 
                405                 410                 415     


Ile Ile His Glu Lys Lys Glu Gly Gly Trp Trp Phe Gly Ser Leu Asn 
            420                 425                 430         


Gly Lys Lys Gly His Phe Pro Ala Ala Tyr Val Glu Glu Leu Pro Ser 
        435                 440                 445             


Asn Ala Gly Asn Thr Ala Thr Lys Ala 
    450                 455         


<210>  8648
<211>  1567
<212>  DNA
<213>  Homosapiens

<400>  8648
ccagaatgct ggagcgtagg tgaaaggaca aaagccagac acatttcaac atgagggacc     60

cactgacaga ttgtccgggc aaacctggaa attagctatg ccaaaggact tcagaaactg    120

gcaagcaagc tgagcaaagc attacagaac acgagaaaaa gttgtgttag cagtgcctgg    180

gcctgggcct cagagggaat gaaatccaca gcggacctgc atcaaaaact tggcaaagca    240

attgaattgg aagcaataaa accgacttat caagtcctaa atgtacaaga gaagaagaga    300

aaatcacttg acaatgaagt tgaaaagaca gcaaatcttg tcattagcaa ctggaatcag    360

caaattaagg caaaagaaat taatggttag taccaagaaa catgaagcac ttttccagct    420

tgtagaaagc tccaagcaat ctatgactga gaaggagaag cggaagctcc tcaataaact    480

gacaaaatca actgaaaagt tggaaaagga agatgaaaat tactaccaaa aaaacatggc    540

gggttattct accagactga aatgggaaaa cacactagag aactgctacc agagcattct    600

ggagctggag aaggaaagaa ttcaactttt atgcaataac ttaaaccagt acagccaaca    660

tatttctctt tttggccaaa ccctgaccac atgccacacg cagattcact gtgccatcag    720

caagattgac attgaaaaag atatccaggc tgtaatggaa gaaactgcaa ttttatctac    780

agaaaacaaa tctgagttcc tgttaacgga ttactttgaa gaagatccta acagtgcaat    840

ggataaagag agacgaaagt ctttactaaa accaaaatta ttgagactgc agagagacat    900

tgaaaaagcc tcaaaagaca aggaaggcct ggaacgaatg cttaaaacgt actccagcac    960

ctcctccttc tctgatgcaa agagccagaa agacacagca gcgttaatgg atgagaacaa   1020

tttgaaacta gaccttttgg aagcgaactc ctacaaactg tcatcaatgt tagcagaact   1080

tgagcaaaga cctcaaccca gccatccttg tagtaattcc atcttcaggt ggagggaaaa   1140

ggagcatact catagctatg tgaaaatatc tcggcctttt ttaatgaaga gattagagaa   1200

tattgtgagc aaggcatctt ctggtgggca gagcaatcca ggttcttcaa ctccagcccc   1260

tggtgcagcc cagctcagca gcagactttg caaggccttg tattcttttc aagccaggca   1320

agatgatgag ttgaatttgg aaaagggtga cattgtgatt atacacgaga aaaaagaagg   1380

aggatggtgg tttggatctt tgaatgggaa aaaaggccat tttcctgccg cttatgtgga   1440

ggagttacct tcaaatgctg gcaacacagc tacaaaggca taaaacaaga ctctgaacat   1500

actaccttca cactcggtaa tcaacaatac agtgtggttc aaataagaat aaagtgctct   1560

taccttt                                                             1567


<210>  8649
<211>  400
<212>  PRT
<213>  Homosapiens

<400>  8649

Met Tyr Lys Arg Arg Arg Glu Asn His Leu Thr Met Lys Leu Lys Arg 
1               5                   10                  15      


Gln Gln Ile Leu Ser Leu Ala Thr Gly Ile Ser Lys Leu Arg Gln Lys 
            20                  25                  30          


Lys Leu Met Val Ser Thr Lys Lys His Glu Ala Leu Phe Gln Leu Val 
        35                  40                  45              


Glu Ser Ser Lys Gln Ser Met Thr Glu Lys Glu Lys Arg Lys Leu Leu 
    50                  55                  60                  


Asn Lys Leu Thr Lys Ser Thr Glu Lys Leu Glu Lys Glu Asp Glu Asn 
65                  70                  75                  80  


Tyr Tyr Gln Lys Asn Met Ala Gly Tyr Ser Thr Arg Leu Lys Trp Glu 
                85                  90                  95      


Asn Thr Leu Glu Asn Cys Tyr Gln Ser Ile Leu Glu Leu Glu Lys Glu 
            100                 105                 110         


Arg Ile Gln Leu Leu Cys Asn Asn Leu Asn Gln Tyr Ser Gln His Ile 
        115                 120                 125             


Ser Leu Phe Gly Gln Thr Leu Thr Thr Cys His Thr Gln Ile His Cys 
    130                 135                 140                 


Ala Ile Ser Lys Ile Asp Ile Glu Lys Asp Ile Gln Ala Val Met Glu 
145                 150                 155                 160 


Glu Thr Ala Ile Leu Ser Thr Glu Asn Lys Ser Glu Phe Leu Leu Thr 
                165                 170                 175     


Asp Tyr Phe Glu Glu Asp Pro Asn Ser Ala Met Asp Lys Glu Arg Arg 
            180                 185                 190         


Lys Ser Leu Leu Lys Pro Lys Leu Leu Arg Leu Gln Arg Asp Ile Glu 
        195                 200                 205             


Lys Ala Ser Lys Asp Lys Glu Gly Leu Glu Arg Met Leu Lys Thr Tyr 
    210                 215                 220                 


Ser Ser Thr Ser Ser Phe Ser Asp Ala Lys Ser Gln Lys Asp Thr Ala 
225                 230                 235                 240 


Ala Leu Met Asp Glu Asn Asn Leu Lys Leu Asp Leu Leu Glu Ala Asn 
                245                 250                 255     


Ser Tyr Lys Leu Ser Ser Met Leu Ala Glu Leu Glu Gln Arg Pro Gln 
            260                 265                 270         


Pro Ser His Pro Cys Ser Asn Ser Ile Phe Arg Trp Arg Glu Lys Glu 
        275                 280                 285             


His Thr His Ser Tyr Val Lys Ile Ser Arg Pro Phe Leu Met Lys Arg 
    290                 295                 300                 


Leu Glu Asn Ile Val Ser Lys Ala Ser Ser Gly Gly Gln Ser Asn Pro 
305                 310                 315                 320 


Gly Ser Ser Thr Pro Ala Pro Gly Ala Ala Gln Leu Ser Ser Arg Leu 
                325                 330                 335     


Cys Lys Ala Leu Tyr Ser Phe Gln Ala Arg Gln Asp Asp Glu Leu Asn 
            340                 345                 350         


Leu Glu Lys Gly Asp Ile Val Ile Ile His Glu Lys Lys Glu Gly Gly 
        355                 360                 365             


Trp Trp Phe Gly Ser Leu Asn Gly Lys Lys Gly His Phe Pro Ala Ala 
    370                 375                 380                 


Tyr Val Glu Glu Leu Pro Ser Asn Ala Gly Asn Thr Ala Thr Lys Ala 
385                 390                 395                 400 


<210>  8650
<211>  1645
<212>  DNA
<213>  Homosapiens

<400>  8650
ctatataagt attatactac tattttcaga aatgtagcat tttaactgtg tttctgaaat     60

tggctagaat gagagataat gtgtttggtt taaaacatgg tcaaccaact gtgcatgaga    120

gttttggatg agttttttgg tttgtttctt ttgacttttg aaacaatgta aaaacctttc    180

aaattaaatt ctgtacgtag aagttaggca tgtcagactg tgaagcagct ctaaagcaac    240

aaggatgaca aaaacgactc cacatttgtg actctgatgt ctacctagta acttgtttta    300

tatggaccac gataactcat tgcaatggaa tactagagag caaattcaag atagaaaaca    360

tttagtgatg tgaataccat aacgaggaag aagccaacgt tgggtaactg ttagcaattg    420

ctagaatggg tcgactgaaa gaatttcaaa atctcatctg gaaaaataac aatcaagatg    480

ctttaagcac cagcacttct caaatttcat taagtgaaga gaaaggtaaa cagttcattt    540

atcattcagt caaatttatt aagaactacc tgcagagact ccctcagcca tttaagaaac    600

cctactggtg gctgggtgct gtggctcacg cctataatcc taacactttg ggaagccaag    660

gcgggtggat cacaaggtca ggcgctggag accagtttgg ccaacatgat gaaactgtgt    720

ctctactaaa aatacgaaaa ttagccggac atggtggcat acacctgtaa tcccagctac    780

tcaagaggct gagggaggag aattgtttga acttgggagg cagaggttgc agtgagccga    840

gatcgcgcca ctgcactcca gcctgggtga cagagcaaga ctccgtctta aaaaaaaaaa    900

tctcactggt atcacttcta ggctcccttt gagagcgacc gactcctggc tgtgtcccac    960

tgagacagtg tgaaaggtga ctgagaacat gatttcattt tcaggcctgg aacgaatgct   1020

taaaacgtac tccagcacct cctccttctc tgatgcaaag agccagaaag acacagcagc   1080

gttaatggat gagaacaatt tgaaactaga ccttttggaa gcgaactcct acaaactgtc   1140

atcaatgtta gcagaacttg agcaaagacc tcaacccagc catccttgta gtaattccat   1200

cttcaggtgg agggaaaagg agcatactca tagctatgtg aaaatatctc ggcctttttt   1260

aatgaagaga ttagagaata ttgtgagcaa ggcatcttct ggtgggcaga gcaatccagg   1320

ttcttcaact ccagcccctg gtgcagccca gctcagcagc agactttgca aggccttgta   1380

ttcttttcaa gccaggcaag atgatgagtt gaatttggaa aagggtgaca ttgtgattat   1440

acacgagaaa aaagaaggag gatggtggtt tggatctttg aatgggaaaa aaggccattt   1500

tcctgccgct tatgtggagg agttaccttc aaatgctggc aacacagcta caaaggcata   1560

aaacaagact ctgaacatac taccttcaca ctcggtaatc aacaatacag tgtggttcaa   1620

ataagaataa agtgctctta ccttt                                         1645


<210>  8651
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  8651

Met Ile Ser Phe Ser Gly Leu Glu Arg Met Leu Lys Thr Tyr Ser Ser 
1               5                   10                  15      


Thr Ser Ser Phe Ser Asp Ala Lys Ser Gln Lys Asp Thr Ala Ala Leu 
            20                  25                  30          


Met Asp Glu Asn Asn Leu Lys Leu Asp Leu Leu Glu Ala Asn Ser Tyr 
        35                  40                  45              


Lys Leu Ser Ser Met Leu Ala Glu Leu Glu Gln Arg Pro Gln Pro Ser 
    50                  55                  60                  


His Pro Cys Ser Asn Ser Ile Phe Arg Trp Arg Glu Lys Glu His Thr 
65                  70                  75                  80  


His Ser Tyr Val Lys Ile Ser Arg Pro Phe Leu Met Lys Arg Leu Glu 
                85                  90                  95      


Asn Ile Val Ser Lys Ala Ser Ser Gly Gly Gln Ser Asn Pro Gly Ser 
            100                 105                 110         


Ser Thr Pro Ala Pro Gly Ala Ala Gln Leu Ser Ser Arg Leu Cys Lys 
        115                 120                 125             


Ala Leu Tyr Ser Phe Gln Ala Arg Gln Asp Asp Glu Leu Asn Leu Glu 
    130                 135                 140                 


Lys Gly Asp Ile Val Ile Ile His Glu Lys Lys Glu Gly Gly Trp Trp 
145                 150                 155                 160 


Phe Gly Ser Leu Asn Gly Lys Lys Gly His Phe Pro Ala Ala Tyr Val 
                165                 170                 175     


Glu Glu Leu Pro Ser Asn Ala Gly Asn Thr Ala Thr Lys Ala 
            180                 185                 190 


<210>  8652
<211>  2090
<212>  DNA
<213>  Homosapiens

<400>  8652
ctatataagt attatactac tattttcaga aatgtagcat tttaactgtg tttctgaaat     60

tggctagaat gagagataat gtgtttggtt taaaacatgg tcaaccaact gtgcatgaga    120

gttttggatg agttttttgg tttgtttctt ttgacttttg aaacaatgta aaaacctttc    180

aaattaaatt ctgtacgtag aagttaggca tgtcagactg tgaagcagct ctaaagcaac    240

aaggatgaca aaaacgactc cacatttgtg actctgatgt ctacctagta acttgtttta    300

tatggaccac gataactcat tgcaatggaa tactagagag caaattcaag atagaaaaca    360

tttagtgatg tgaataccat aacgaggaag aagccaacgt tgggtaactg ttagcaattg    420

ctagaatggg tcgactgaaa gaatttcaaa atctcatctg gaaaaataac aatcaagatg    480

ctttaagcac cagcacttct caaatttcat taagtgaaga gaaaggtaaa cagttcattt    540

atcattcagt caaatttatt aagaactacc tgcagagact ccctcagcca tttaagaaac    600

cctactggtg gctgggtgct gtggctcacg cctataatcc taacactttg ggaagccaag    660

gcgggtggat cacaaggtca ggcgctggag accagtttgg ccaacatgat gaaactgtgt    720

ctctactaaa aatacgaaaa ttagccggac atggtggcat acacctgtaa tcccagctac    780

tcaagaggct gagggaggag aattgtttga acttgggagg cagaggttgc agtgagccga    840

gatcgcgcca ctgcactcca gcctgggtga cagagcaaga ctccgtctta aaaaaaaaaa    900

tctcactggt atcacttcta ggctcccttt gagagcgacc gactcctggc tgtgtcccac    960

tgagacagtg tgaaaggtga ctgagaacat gatttcattt tcaggcctgg aacgaatgct   1020

taaaacgtac tccagcacct cctccttctc tgatgcaaag agccagaaag acacagcagc   1080

gttaatggat gagaacaatt tgaaactaga ccttttggaa gcgaactcct acaaactgtc   1140

atcaatgtta gcagaacttg agcaaagacc tcaacccagc catccttgta gtaattccat   1200

cttcaggtgg agggaaaagg agcatactca tagctatgtg aaaatatctc ggcctttttt   1260

aatgaagaga ttagagaata ttgtgagcaa ggcatcttct ggtgggcaga gcaatccagg   1320

ttcttcaact ccagcccctg gtgcagccca gctcagcagc agactttgca aggccttgta   1380

ttcttttcaa gccaggcaag atgatgagtt gaatttggaa aagggtgaca ttgtgattat   1440

acacgagaaa aaagaaggag gatggtggtt tggatctttg aatgggaaaa aaggccattt   1500

tcctgccgct tatgtggagg agttaccttc aaatgctggc aacacagcta caaaggcata   1560

aaacaagact ctgaacatac taccttcaca ctcggtaatc aacaatacag tgtggttcaa   1620

ataagaataa agtgctctta cctttacatg tttttctttt gaaatggatg gagttctacc   1680

tgcatgtcac agcactttgc attcatgatt attagcttga aacagtcaga aaaaagatgg   1740

atgggtggag acagacaagg aagaggctcc ttggttccta gaggagtttc caaattctag   1800

gagaccctag agatgatcca gtataacccc tggtgtcaca gaaacagacg gagtccaagg   1860

tgggttcagc tgcttgcctg aagtcagagt tatctggtag acaacagcag tgggacttag   1920

atgtcttttt cctctggatt tgggtggcaa cagaacacag caggcctatg agggggtcaa   1980

gcagagcctg ggagatgagg aacacagatc aattccaaga agagagacag gcaatcaaga   2040

caccaatgag atcaacccaa attaggggat ggtaggatat ctctgacaaa              2090


<210>  8653
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  8653

Met Ile Ser Phe Ser Gly Leu Glu Arg Met Leu Lys Thr Tyr Ser Ser 
1               5                   10                  15      


Thr Ser Ser Phe Ser Asp Ala Lys Ser Gln Lys Asp Thr Ala Ala Leu 
            20                  25                  30          


Met Asp Glu Asn Asn Leu Lys Leu Asp Leu Leu Glu Ala Asn Ser Tyr 
        35                  40                  45              


Lys Leu Ser Ser Met Leu Ala Glu Leu Glu Gln Arg Pro Gln Pro Ser 
    50                  55                  60                  


His Pro Cys Ser Asn Ser Ile Phe Arg Trp Arg Glu Lys Glu His Thr 
65                  70                  75                  80  


His Ser Tyr Val Lys Ile Ser Arg Pro Phe Leu Met Lys Arg Leu Glu 
                85                  90                  95      


Asn Ile Val Ser Lys Ala Ser Ser Gly Gly Gln Ser Asn Pro Gly Ser 
            100                 105                 110         


Ser Thr Pro Ala Pro Gly Ala Ala Gln Leu Ser Ser Arg Leu Cys Lys 
        115                 120                 125             


Ala Leu Tyr Ser Phe Gln Ala Arg Gln Asp Asp Glu Leu Asn Leu Glu 
    130                 135                 140                 


Lys Gly Asp Ile Val Ile Ile His Glu Lys Lys Glu Gly Gly Trp Trp 
145                 150                 155                 160 


Phe Gly Ser Leu Asn Gly Lys Lys Gly His Phe Pro Ala Ala Tyr Val 
                165                 170                 175     


Glu Glu Leu Pro Ser Asn Ala Gly Asn Thr Ala Thr Lys Ala 
            180                 185                 190 


<210>  8654
<211>  910
<212>  DNA
<213>  Homosapiens

<400>  8654
ggcgggtggc gggaagtgca ctaggtttga aatcggaaag ttggcggggc tgcgggagct     60

gagcctagag tccggctgtt ggctagagtg ggcgcggatc tggtgtgggg aaggcggcgg    120

gactcaggcc tgcctgcgaa gcattgtcct acataatggt agaggacgaa ctggcacttt    180

tcgataaaag cataaatgaa ttttggaata aattcaaaag tacggacacc tcctgtcaga    240

tggcgggact aagagatacc tacaaggatt ccatcaaagc atttgcagaa aagctgtctg    300

tgaaattaaa ggaagaagaa cgaatggttg agatgtttct ggaatatcaa aatcagatca    360

gcaggcaaaa taagctcatt caagaaaaaa aggataactt gttaaaattg attgctgaag    420

taaaaggcaa aaagcaggaa ttggaagtac tgactgcaaa tatccaggat cttaaggaag    480

aatattctag gaagaaggaa actatttcta ctgctaataa agcgaatgca gagaggttga    540

aaaggctgca gaaatctgca gacttgtata aagatcgact tggactagaa attcgaaaaa    600

tttatggtga gaaattgcag tttattttca ctaatattga ccctaagaat cctgagagcc    660

catttatgtt ttccttacat ctcaatgaag caagggacta tgaaggctct gcttgacccc    720

ctcataggcc tgctgtgttc tgttgccacc caaatccaga ggaaaaagac atctaagtcc    780

cactgctgtt gtctaccaga taactctgac ttcaggcaag cagctgaacc caccttggac    840

tccgtctgtt tctgtgacac caggggttat actggatcat ctctagggtc tcctagaatt    900

tggaaactcc                                                           910


<210>  8655
<211>  186
<212>  PRT
<213>  Homosapiens

<400>  8655

Met Val Glu Asp Glu Leu Ala Leu Phe Asp Lys Ser Ile Asn Glu Phe 
1               5                   10                  15      


Trp Asn Lys Phe Lys Ser Thr Asp Thr Ser Cys Gln Met Ala Gly Leu 
            20                  25                  30          


Arg Asp Thr Tyr Lys Asp Ser Ile Lys Ala Phe Ala Glu Lys Leu Ser 
        35                  40                  45              


Val Lys Leu Lys Glu Glu Glu Arg Met Val Glu Met Phe Leu Glu Tyr 
    50                  55                  60                  


Gln Asn Gln Ile Ser Arg Gln Asn Lys Leu Ile Gln Glu Lys Lys Asp 
65                  70                  75                  80  


Asn Leu Leu Lys Leu Ile Ala Glu Val Lys Gly Lys Lys Gln Glu Leu 
                85                  90                  95      


Glu Val Leu Thr Ala Asn Ile Gln Asp Leu Lys Glu Glu Tyr Ser Arg 
            100                 105                 110         


Lys Lys Glu Thr Ile Ser Thr Ala Asn Lys Ala Asn Ala Glu Arg Leu 
        115                 120                 125             


Lys Arg Leu Gln Lys Ser Ala Asp Leu Tyr Lys Asp Arg Leu Gly Leu 
    130                 135                 140                 


Glu Ile Arg Lys Ile Tyr Gly Glu Lys Leu Gln Phe Ile Phe Thr Asn 
145                 150                 155                 160 


Ile Asp Pro Lys Asn Pro Glu Ser Pro Phe Met Phe Ser Leu His Leu 
                165                 170                 175     


Asn Glu Ala Arg Asp Tyr Glu Gly Ser Ala 
            180                 185     


<210>  8656
<211>  1369
<212>  DNA
<213>  Homosapiens

<400>  8656
ggcgggtggc gggaagtgca ctaggtttga aatcggaaag ttggcggggc tgcgggagct     60

gagcctagag tccggctgtt ggctagagtg ggcgcggatc tggtgtgggg aaggcggcgg    120

gactcaggcc tgcctgcgaa gcattgtcct acataatggt agaggacgaa ctggcacttt    180

tcgataaaag cataaatgaa ttttggaata aattcaaaag tacggacacc tcctgtcaga    240

tggcgggact aagagatacc tacaaggatt ccatcaaagc atttgcagaa aagctgtctg    300

tgaaattaaa ggaagaagaa cgaatggttg agatgtttct ggaatatcaa aatcagatca    360

gcaggcaaaa taagctcatt caagaaaaaa aggataactt gttaaaattg attgctgaag    420

taaaaggcaa aaagcaggaa ttggaagtac tgactgcaaa tatccaggat cttaaggaag    480

aatattctag gaagaaggaa actatttcta ctgctaataa agcgaatgca gagaggttga    540

aaaggctgca gaaatctgca gacttgtata aagatcgact tggactagaa attcgaaaaa    600

tttatggtga gaaattgcag tttattttca ctaatattga ccctaagaat cctgagagcc    660

catttatgtt ttccttacat ctcaatgaag caagggacta tgaagtgtca gatagtgccc    720

ctcatcttga gggcctagca gaatttcaag agaatgtaag gaagaccaac aatttttcag    780

cttttcttgc caatgttcgg aaagctttta ctgccacggt ttataattaa catacaaata    840

gtgtatataa aaacggttta tttttcttct ctattacata tctctttttt tcttgttttt    900

attattatta tactttaagt tttagggtac atgtgcacaa tgtgcaggtt tgttacatat    960

gtatacatgt gccatattgg tgtgctgcac ccattaactc gtcatttcat taggtatatc   1020

tcctaatgct atccctcccc cctcccccaa cccacaacag tccccgttgt gtgatgttcc   1080

ccttcctgtg tccatgtgtt ctcattgttc aattcccacc taggagtgag aatatgtggt   1140

gtttggtttt ttgtcctttc gatagtttgc tgagaatgat ggtttccagc ttcatccatg   1200

ttcctacaaa ggacatgaac tcatcctttt ttatggctgc atagtattcc atggtgtata   1260

tgtgccacat tttcttaatc cagtctatca ttgttggaca tttgggttgg ttccaagtct   1320

ttgctattgt gaatagtgcc gaaataaaca tacgtgtgca tgtgtcttt               1369


<210>  8657
<211>  224
<212>  PRT
<213>  Homosapiens

<400>  8657

Met Val Glu Asp Glu Leu Ala Leu Phe Asp Lys Ser Ile Asn Glu Phe 
1               5                   10                  15      


Trp Asn Lys Phe Lys Ser Thr Asp Thr Ser Cys Gln Met Ala Gly Leu 
            20                  25                  30          


Arg Asp Thr Tyr Lys Asp Ser Ile Lys Ala Phe Ala Glu Lys Leu Ser 
        35                  40                  45              


Val Lys Leu Lys Glu Glu Glu Arg Met Val Glu Met Phe Leu Glu Tyr 
    50                  55                  60                  


Gln Asn Gln Ile Ser Arg Gln Asn Lys Leu Ile Gln Glu Lys Lys Asp 
65                  70                  75                  80  


Asn Leu Leu Lys Leu Ile Ala Glu Val Lys Gly Lys Lys Gln Glu Leu 
                85                  90                  95      


Glu Val Leu Thr Ala Asn Ile Gln Asp Leu Lys Glu Glu Tyr Ser Arg 
            100                 105                 110         


Lys Lys Glu Thr Ile Ser Thr Ala Asn Lys Ala Asn Ala Glu Arg Leu 
        115                 120                 125             


Lys Arg Leu Gln Lys Ser Ala Asp Leu Tyr Lys Asp Arg Leu Gly Leu 
    130                 135                 140                 


Glu Ile Arg Lys Ile Tyr Gly Glu Lys Leu Gln Phe Ile Phe Thr Asn 
145                 150                 155                 160 


Ile Asp Pro Lys Asn Pro Glu Ser Pro Phe Met Phe Ser Leu His Leu 
                165                 170                 175     


Asn Glu Ala Arg Asp Tyr Glu Val Ser Asp Ser Ala Pro His Leu Glu 
            180                 185                 190         


Gly Leu Ala Glu Phe Gln Glu Asn Val Arg Lys Thr Asn Asn Phe Ser 
        195                 200                 205             


Ala Phe Leu Ala Asn Val Arg Lys Ala Phe Thr Ala Thr Val Tyr Asn 
    210                 215                 220                 


<210>  8658
<211>  1311
<212>  DNA
<213>  Homosapiens

<400>  8658
ggcgggtggc gggaagtgca ctaggtttga aatcggaaag ttggcggggc tgcgggagct     60

gagcctagag tccggctgtt ggctagagtg ggcgcggatc tggtgtgggg aaggcggcgg    120

gactcaggcc tgcctgcgaa gcattgtcct acataatggt agaggacgaa ctggcacttt    180

tcgataaaag cataaatgaa ttttggaata aattcaaaag tacggacacc tcctgtcaga    240

tggcgggact aagagatacc tacaaggatt ccatcaaagc atttgcagaa aagctgtctg    300

tgaaattaaa ggaagaagaa cgaatggttg agatgtttct ggaatatcaa aatcagatca    360

gcaggcaaaa taagctcatt caagaaaaaa aggataactt gttaaaattg attgctgaag    420

taaaaggcaa aaagcaggaa ttggaagtac tgactgcaaa tatccaggat cttaaggaag    480

aatattctag gaagaaggaa actatttcta ctgctaataa agcgaatgca gagaggttga    540

aaaggctgca gaaatctgca gacttgtata aagatcgact tggactagaa attcaatcct    600

gagagcccat ttatgttttc cttacatctc aatgaagcaa gggactatga agtgtcagat    660

agtgcccctc atcttgaggg cctagcagaa tttcaagaga atgtaaggaa gaccaacaat    720

ttttcagctt ttcttgccaa tgttcggaaa gcttttactg ccacggttta taattaacat    780

acaaatagtg tatataaaaa cggtttattt ttcttctcta ttacatatct ctttttttct    840

tgtttttatt attattatac tttaagtttt agggtacatg tgcacaatgt gcaggtttgt    900

tacatatgta tacatgtgcc atattggtgt gctgcaccca ttaactcgtc atttcattag    960

gtatatctcc taatgctatc cctcccccct cccccaaccc acaacagtcc ccgttgtgtg   1020

atgttcccct tcctgtgtcc atgtgttctc attgttcaat tcccacctag gagtgagaat   1080

atgtggtgtt tggttttttg tcctttcgat agtttgctga gaatgatggt ttccagcttc   1140

atccatgttc ctacaaagga catgaactca tcctttttta tggctgcata gtattccatg   1200

gtgtatatgt gccacatttt cttaatccag tctatcattg ttggacattt gggttggttc   1260

caagtctttg ctattgtgaa tagtgccgaa ataaacatac gtgtgcatgt g            1311


<210>  8659
<211>  148
<212>  PRT
<213>  Homosapiens

<400>  8659

Met Val Glu Asp Glu Leu Ala Leu Phe Asp Lys Ser Ile Asn Glu Phe 
1               5                   10                  15      


Trp Asn Lys Phe Lys Ser Thr Asp Thr Ser Cys Gln Met Ala Gly Leu 
            20                  25                  30          


Arg Asp Thr Tyr Lys Asp Ser Ile Lys Ala Phe Ala Glu Lys Leu Ser 
        35                  40                  45              


Val Lys Leu Lys Glu Glu Glu Arg Met Val Glu Met Phe Leu Glu Tyr 
    50                  55                  60                  


Gln Asn Gln Ile Ser Arg Gln Asn Lys Leu Ile Gln Glu Lys Lys Asp 
65                  70                  75                  80  


Asn Leu Leu Lys Leu Ile Ala Glu Val Lys Gly Lys Lys Gln Glu Leu 
                85                  90                  95      


Glu Val Leu Thr Ala Asn Ile Gln Asp Leu Lys Glu Glu Tyr Ser Arg 
            100                 105                 110         


Lys Lys Glu Thr Ile Ser Thr Ala Asn Lys Ala Asn Ala Glu Arg Leu 
        115                 120                 125             


Lys Arg Leu Gln Lys Ser Ala Asp Leu Tyr Lys Asp Arg Leu Gly Leu 
    130                 135                 140                 


Glu Ile Gln Ser 
145             


<210>  8660
<211>  875
<212>  DNA
<213>  Homosapiens

<400>  8660
ggcgggtggc gggaagtgca ctaggtttga aatcggaaag ttggcggggc tgcgggagct     60

gagcctagag tccggctgtt ggctagagtg ggcgcggatc tggtgtgggg aaggcggcgg    120

gactcaggcc tgcctgcgaa gcattgtcct acataatggt agaggacgaa ctggcacttt    180

tcgataaaag cataaatgaa ttttggaata aattcaaaag tacggacacc tcctgtcaga    240

tggcgggact aagagatacc tacaaggatt ccatcaaagc atttgcagaa aagctgtctg    300

tgaaattaaa ggaagaagaa cgaatggttg agatgtttct ggaatatcaa aatcagatca    360

gcaggcaaaa taagctcatt caagaaaaaa aggataactt gttaaaattg attgctgaag    420

taaaaggcaa aaagcaggaa ttggaagtac tgactgcaaa tatccaggat cttaaggaag    480

aatattctag gaagaaggaa actatttcta ctgctaataa agcgaatgca gagaggttga    540

aaaggctgca gaaatctgca gacttgtata aagatcgact tggactagaa attcgaaaaa    600

tttatggtga gaaattgcag tttattttca ctaatattga ccctaagaat cctgagagcc    660

catttatgtt ttccttacat ctcaatgaag caagggacta tgaagtgtca gatagtgccc    720

ctcatcttga gggcctagca gaatttcaag agaatgtaag gaagaccaac aatttttcag    780

cttttcttgc caatgttcgg aaagctttta ctgccacggt ttataattaa catacaaata    840

gtgtatataa aaacggttta tttttcttct ctatt                               875


<210>  8661
<211>  224
<212>  PRT
<213>  Homosapiens

<400>  8661

Met Val Glu Asp Glu Leu Ala Leu Phe Asp Lys Ser Ile Asn Glu Phe 
1               5                   10                  15      


Trp Asn Lys Phe Lys Ser Thr Asp Thr Ser Cys Gln Met Ala Gly Leu 
            20                  25                  30          


Arg Asp Thr Tyr Lys Asp Ser Ile Lys Ala Phe Ala Glu Lys Leu Ser 
        35                  40                  45              


Val Lys Leu Lys Glu Glu Glu Arg Met Val Glu Met Phe Leu Glu Tyr 
    50                  55                  60                  


Gln Asn Gln Ile Ser Arg Gln Asn Lys Leu Ile Gln Glu Lys Lys Asp 
65                  70                  75                  80  


Asn Leu Leu Lys Leu Ile Ala Glu Val Lys Gly Lys Lys Gln Glu Leu 
                85                  90                  95      


Glu Val Leu Thr Ala Asn Ile Gln Asp Leu Lys Glu Glu Tyr Ser Arg 
            100                 105                 110         


Lys Lys Glu Thr Ile Ser Thr Ala Asn Lys Ala Asn Ala Glu Arg Leu 
        115                 120                 125             


Lys Arg Leu Gln Lys Ser Ala Asp Leu Tyr Lys Asp Arg Leu Gly Leu 
    130                 135                 140                 


Glu Ile Arg Lys Ile Tyr Gly Glu Lys Leu Gln Phe Ile Phe Thr Asn 
145                 150                 155                 160 


Ile Asp Pro Lys Asn Pro Glu Ser Pro Phe Met Phe Ser Leu His Leu 
                165                 170                 175     


Asn Glu Ala Arg Asp Tyr Glu Val Ser Asp Ser Ala Pro His Leu Glu 
            180                 185                 190         


Gly Leu Ala Glu Phe Gln Glu Asn Val Arg Lys Thr Asn Asn Phe Ser 
        195                 200                 205             


Ala Phe Leu Ala Asn Val Arg Lys Ala Phe Thr Ala Thr Val Tyr Asn 
    210                 215                 220                 


<210>  8662
<211>  819
<212>  DNA
<213>  Homosapiens

<400>  8662
ggcgggtggc gggaagtgca ctaggtttga aatcggaaag ttggcggggc tgcgggagct     60

gagcctagag tccggctgtt ggctagagtg ggcgcggatc tggtgtgggg aaggcggcgg    120

gactcaggcc tgcctgcgaa gcattgtcct acataatggt agaggacgaa ctggcacttt    180

tcgataaaag cataaatgaa ttttggaata aattcaaaag tacggacacc tcctgtcaga    240

tggcgggact aagagatacc tacaaggatt ccatcaaagc atttgcagaa aagctgtctg    300

tgaaattaaa ggaagaagaa cgaatggttg agatgtttct ggaatatcaa aatcagatca    360

gcaggcaaaa taagctcatt caagaaaaaa aggataactt gttaaaattg attgctgaag    420

taaaaggcaa aaagcaggaa ttggaagtac tgactgcaaa tatccaggat cttaaggaag    480

aatattctag gaagaaggaa actatttcta ctgctaataa agcgaatgca gagaggttga    540

aaaggctgca gaaatctgca gacttgtata aagatcgact tggactagaa attcaatcct    600

gagagcccat ttatgttttc cttacatctc aatgaagcaa gggactatga agtgtcagat    660

agtgcccctc atcttgaggg cctagcagaa tttcaagaga atgtaaggaa gaccaacaat    720

ttttcagctt ttcttgccaa tgttcggaaa gcttttactg ccacggttta taattaacat    780

acaaatagtg tatataaaaa cggtttattt ttcttctct                           819


<210>  8663
<211>  148
<212>  PRT
<213>  Homosapiens

<400>  8663

Met Val Glu Asp Glu Leu Ala Leu Phe Asp Lys Ser Ile Asn Glu Phe 
1               5                   10                  15      


Trp Asn Lys Phe Lys Ser Thr Asp Thr Ser Cys Gln Met Ala Gly Leu 
            20                  25                  30          


Arg Asp Thr Tyr Lys Asp Ser Ile Lys Ala Phe Ala Glu Lys Leu Ser 
        35                  40                  45              


Val Lys Leu Lys Glu Glu Glu Arg Met Val Glu Met Phe Leu Glu Tyr 
    50                  55                  60                  


Gln Asn Gln Ile Ser Arg Gln Asn Lys Leu Ile Gln Glu Lys Lys Asp 
65                  70                  75                  80  


Asn Leu Leu Lys Leu Ile Ala Glu Val Lys Gly Lys Lys Gln Glu Leu 
                85                  90                  95      


Glu Val Leu Thr Ala Asn Ile Gln Asp Leu Lys Glu Glu Tyr Ser Arg 
            100                 105                 110         


Lys Lys Glu Thr Ile Ser Thr Ala Asn Lys Ala Asn Ala Glu Arg Leu 
        115                 120                 125             


Lys Arg Leu Gln Lys Ser Ala Asp Leu Tyr Lys Asp Arg Leu Gly Leu 
    130                 135                 140                 


Glu Ile Gln Ser 
145             


<210>  8664
<211>  492
<212>  DNA
<213>  Homosapiens

<400>  8664
ggcgggtggc gggaagtgca ctaggtttga aatcggaaag ttggcggggc tgcgggagct     60

gagcctagag tccggctgtt ggctagagtg ggcgcggatc tggtgtgggg aaggcggcgg    120

gactcaggcc tgcctgcgaa gcattgtcct acataatggt agaggacgaa ctggcacttt    180

tcgataaaag cataaatgaa ttttggaata aattcaaaag tacggacacc tcctgtcaga    240

tggcgggact aagagatacc tacaaggatt ccatcaaagc atttgcagaa aagctgtctg    300

tgaaattaaa ggaagaagaa cgaatggttg agatgtttct ggaatatcaa aatcagatca    360

gcaggcaaaa taagctcatt caagaaaaaa aggataactt gttaaaattg attgctgaag    420

taaaaggcaa aaagcaggaa ttggaactat ttctactgct aataaagcga atgcagagag    480

gttgaaaagg ct                                                        492


<210>  8665
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  8665

Met Val Glu Asp Glu Leu Ala Leu Phe Asp Lys Ser Ile Asn Glu Phe 
1               5                   10                  15      


Trp Asn Lys Phe Lys Ser Thr Asp Thr Ser Cys Gln Met Ala Gly Leu 
            20                  25                  30          


Arg Asp Thr Tyr Lys Asp Ser Ile Lys Ala Phe Ala Glu Lys Leu Ser 
        35                  40                  45              


Val Lys Leu Lys Glu Glu Glu Arg Met Val Glu Met Phe Leu Glu Tyr 
    50                  55                  60                  


Gln Asn Gln Ile Ser Arg Gln Asn Lys Leu Ile Gln Glu Lys Lys Asp 
65                  70                  75                  80  


Asn Leu Leu Lys Leu Ile Ala Glu Val Lys Gly Lys Lys Gln Glu Leu 
                85                  90                  95      


Glu Leu Phe Leu Leu Leu Ile Lys Arg Met Gln Arg Gly 
            100                 105                 


<210>  8666
<211>  1393
<212>  DNA
<213>  Homosapiens

<400>  8666
agctccaatt gctctatgtt tagaattgcc tctttttcaa gatggatttc cttcacagga     60

atggagtgct cataattcag catttgcaga aggactaccg agcttactac acttttctaa    120

attttatgtc caatgttgga gaccccagga atatcttttt catttatttt ccactttgtt    180

ttcaatttaa tcagacagtt ggaaccaaga tgatatgggt agcagtcatt ggggattggt    240

taaatcttat atttaaatgg atattatttg gtcatcgacc ttactggtgg gtccaagaaa    300

ctcagattta cccaaatcac tcaagtccat gccttgaaca gttccctact acatgtgaaa    360

caggtccagg aagtccatct ggccatgcaa tgggcgcatc ctgtgtctgg tatgtcatgg    420

taaccgctgc cctgagccac actgtctgtg ggatggataa gttctctatc actctgcaca    480

ggcatgctgg tggcagaggc ctttgaacac actccaggca tccaaacggc cagtctgggc    540

acatacctga agaccaacct ctttctcttc ctgtttgcag ttggctttta cctgcttctt    600

agggtgctca acattgacct gctgtggtcc gtgcccatag ccaaaaagtg gtgtgctaac    660

cccgactgga tccacattga caccacgcct tttgctggac tcgtgagaaa ccttggggtc    720

ctctttggct tgggctttgc aatcaactca gagatgttcc tcctgagctg ccgaggggga    780

aataactaca cactgagctt ccggttgctc tgtgccttga cctcattgac aatactgcag    840

ctctaccatt tcctccagat cccgactcac gaagagcatt tattttatgt gctgtctttt    900

tgtaaaagtg catccattcc cctaactgtg gttgctttca ttccctactc tgttcatatg    960

ttaatgaaac aaagcggaaa gaagagtcag tagagtggtg cctagagtta gtgctctgtg   1020

tcacagatca cccttctcca tccaccagta gagccacaga gtaggcacag accagaggct   1080

tctaatccga cttcacagaa tagcggcaca ggccccattc cccatagaga tgtttagttt   1140

ggccttcgca ctggtctttt tttttaatcc ttcagttacc aatatttaga tacaagaata   1200

tttgacataa aaatcggaag ttctgtattt cttgaaaaat ctgatagtat gacaacacag   1260

agcctgcatc cccagctgga gacaactgac cagagctgca tactaacagt ccccagtagg   1320

aggcaaggac tccattttct cacagtcttc agcatcccag caggagcccc actatgattc   1380

ctttatcttc tta                                                      1393


<210>  8667
<211>  154
<212>  PRT
<213>  Homosapiens

<400>  8667

Met Asp Phe Leu His Arg Asn Gly Val Leu Ile Ile Gln His Leu Gln 
1               5                   10                  15      


Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val 
            20                  25                  30          


Gly Asp Pro Arg Asn Ile Phe Phe Ile Tyr Phe Pro Leu Cys Phe Gln 
        35                  40                  45              


Phe Asn Gln Thr Val Gly Thr Lys Met Ile Trp Val Ala Val Ile Gly 
    50                  55                  60                  


Asp Trp Leu Asn Leu Ile Phe Lys Trp Ile Leu Phe Gly His Arg Pro 
65                  70                  75                  80  


Tyr Trp Trp Val Gln Glu Thr Gln Ile Tyr Pro Asn His Ser Ser Pro 
                85                  90                  95      


Cys Leu Glu Gln Phe Pro Thr Thr Cys Glu Thr Gly Pro Gly Ser Pro 
            100                 105                 110         


Ser Gly His Ala Met Gly Ala Ser Cys Val Trp Tyr Val Met Val Thr 
        115                 120                 125             


Ala Ala Leu Ser His Thr Val Cys Gly Met Asp Lys Phe Ser Ile Thr 
    130                 135                 140                 


Leu His Arg His Ala Gly Gly Arg Gly Leu 
145                 150                 


<210>  8668
<211>  1478
<212>  DNA
<213>  Homosapiens

<400>  8668
ctttttcaag atggatttcc ttcacaggaa tggagtgctc ataattcagc atttgcagaa     60

ggactaccga gcttactaca cttttctaaa ttttatgtcc aatgttggag accccaggaa    120

tatctttttc atttattttc cactttgttt tcaatttaat cagacagttg gaaccaagat    180

gatatgggta gcagtcattg gggattggtt aaatcttata tttaaatgga tattatttgg    240

tcatcgacct tactggtggg tccaagaaac tcagatttac ccaaatcact caagtccatg    300

ccttgaacag ttccctacta catgtgaaac aggtccagga agtccatctg gccatgcaat    360

gggcgcatcc tgtgtctggt atgtcatggt aaccgctgcc ctgagccaca ctgtctgtgg    420

gatggataag ttctctatca ctctgcacag actgacctgg tcatttcttt ggagtgtttt    480

ttggttgatt caaatcagtg tctgcatctc cagagtattc atagcaacac attttcctca    540

tcaagttatt cttggagtaa ttggtggcat gctggtggca gaggcctttg aacacactcc    600

aggcatccaa acggccagtc tgggcacata cctgaagacc aacctctttc tcttcctgtt    660

tgcagttggc ttttacctgc ttcttagggt gctcaacatt gacctgctgt ggtccgtgcc    720

catagccaaa aagtggtgtg ctaaccccga ctggatccac attgacacca cgccttttgc    780

tggactcgtg agaaaccttg gggtcctctt tggcttgggc tttgcaatca actcagagat    840

gttcctcctg agctgccgag ggggaaataa ctacacactg agcttccggt tgctctgtgc    900

cttgacctca ttgacaatac tgcagctcta ccatttcctc cagatcccga ctcacgaaga    960

gcatttattt tatgtgctgt ctttttgtaa aagtgcatcc attcccctaa ctgtggttgc   1020

tttcattccc tactctgttc atatgttaat gaaacaaagc ggaaagaaga gtcagtagag   1080

tggtgcctag agttagtgct ctgtgtcaca gatcaccctt ctccatccac cagtagagcc   1140

acagagtagg cacagaccag aggcttctaa tccgacttca cagaatagcg gcacaggccc   1200

cattccccat agagatgttt agtttggcct tcgcactggt cttttttttt aatccttcag   1260

ttaccaatat ttagatacaa gaatatttga cataaaaatc ggaagttctg tatttcttga   1320

aaaatctgat agtatgacaa cacagagcct gcatccccag ctggagacaa ctgaccagag   1380

ctgcatacta acagtcccca gtaggaggca aggactccat tttctcacag tcttcagcat   1440

cccagcagga gccccactat gattccttta tcttctta                           1478


<210>  8669
<211>  355
<212>  PRT
<213>  Homosapiens

<400>  8669

Met Asp Phe Leu His Arg Asn Gly Val Leu Ile Ile Gln His Leu Gln 
1               5                   10                  15      


Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val 
            20                  25                  30          


Gly Asp Pro Arg Asn Ile Phe Phe Ile Tyr Phe Pro Leu Cys Phe Gln 
        35                  40                  45              


Phe Asn Gln Thr Val Gly Thr Lys Met Ile Trp Val Ala Val Ile Gly 
    50                  55                  60                  


Asp Trp Leu Asn Leu Ile Phe Lys Trp Ile Leu Phe Gly His Arg Pro 
65                  70                  75                  80  


Tyr Trp Trp Val Gln Glu Thr Gln Ile Tyr Pro Asn His Ser Ser Pro 
                85                  90                  95      


Cys Leu Glu Gln Phe Pro Thr Thr Cys Glu Thr Gly Pro Gly Ser Pro 
            100                 105                 110         


Ser Gly His Ala Met Gly Ala Ser Cys Val Trp Tyr Val Met Val Thr 
        115                 120                 125             


Ala Ala Leu Ser His Thr Val Cys Gly Met Asp Lys Phe Ser Ile Thr 
    130                 135                 140                 


Leu His Arg Leu Thr Trp Ser Phe Leu Trp Ser Val Phe Trp Leu Ile 
145                 150                 155                 160 


Gln Ile Ser Val Cys Ile Ser Arg Val Phe Ile Ala Thr His Phe Pro 
                165                 170                 175     


His Gln Val Ile Leu Gly Val Ile Gly Gly Met Leu Val Ala Glu Ala 
            180                 185                 190         


Phe Glu His Thr Pro Gly Ile Gln Thr Ala Ser Leu Gly Thr Tyr Leu 
        195                 200                 205             


Lys Thr Asn Leu Phe Leu Phe Leu Phe Ala Val Gly Phe Tyr Leu Leu 
    210                 215                 220                 


Leu Arg Val Leu Asn Ile Asp Leu Leu Trp Ser Val Pro Ile Ala Lys 
225                 230                 235                 240 


Lys Trp Cys Ala Asn Pro Asp Trp Ile His Ile Asp Thr Thr Pro Phe 
                245                 250                 255     


Ala Gly Leu Val Arg Asn Leu Gly Val Leu Phe Gly Leu Gly Phe Ala 
            260                 265                 270         


Ile Asn Ser Glu Met Phe Leu Leu Ser Cys Arg Gly Gly Asn Asn Tyr 
        275                 280                 285             


Thr Leu Ser Phe Arg Leu Leu Cys Ala Leu Thr Ser Leu Thr Ile Leu 
    290                 295                 300                 


Gln Leu Tyr His Phe Leu Gln Ile Pro Thr His Glu Glu His Leu Phe 
305                 310                 315                 320 


Tyr Val Leu Ser Phe Cys Lys Ser Ala Ser Ile Pro Leu Thr Val Val 
                325                 330                 335     


Ala Phe Ile Pro Tyr Ser Val His Met Leu Met Lys Gln Ser Gly Lys 
            340                 345                 350         


Lys Ser Gln 
        355 


<210>  8670
<211>  1137
<212>  DNA
<213>  Homosapiens

<400>  8670
tttcaagatg gatttccttc acaggaatgg agtgctcata attcagcatt tgcagaagga     60

ctaccgagct tactacactt ttctaaattt tatgtccaat gttggagacc ccaggaatat    120

ctttttcatt tattttccac tttgttttca atttaatcag acagttggaa ccaagatgat    180

atgggtagca gtcattgggg attggttaaa tcttatattt aaatggcatg ctggtggcag    240

aggcctttga acacactcca ggcatccaaa cggccagtct gggcacatac ctgaagacca    300

acctctttct cttcctgttt gcagttggct tttacctgct tcttagggtg ctcaacattg    360

acctgctgtg gtccgtgccc atagccaaaa agtggtgtgc taaccccgac tggatccaca    420

ttgacaccac gccttttgct ggactcgtga gaaaccttgg ggtcctcttt ggcttgggct    480

ttgcaatcaa ctcagagatg ttcctcctga gctgccgagg gggaaataac tacacactga    540

gcttccggtt gctctgtgcc ttgacctcat tgacaatact gcagctctac catttcctcc    600

agatcccgac tcacgaagag catttatttt atgtgctgtc tttttgtaaa agtgcatcca    660

ttcccctaac tgtggttgct ttcattccct actctgttca tatgttaatg aaacaaagcg    720

gaaagaagag tcagtagagt ggtgcctaga gttagtgctc tgtgtcacag atcacccttc    780

tccatccacc agtagagcca cagagtaggc acagaccaga ggcttctaat ccgacttcac    840

agaatagcgg cacaggcccc attccccata gagatgttta gtttggcctt cgcactggtc    900

ttttttttta atccttcagt taccaatatt tagatacaag aatatttgac ataaaaatcg    960

gaagttctgt atttcttgaa aaatctgata gtatgacaac acagagcctg catccccagc   1020

tggagacaac tgaccagagc tgcatactaa cagtccccag taggaggcaa ggactccatt   1080

ttctcacagt cttcagcatc ccagcaggag ccccactatg attcctttat cttctta      1137


<210>  8671
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  8671

Met Asp Phe Leu His Arg Asn Gly Val Leu Ile Ile Gln His Leu Gln 
1               5                   10                  15      


Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val 
            20                  25                  30          


Gly Asp Pro Arg Asn Ile Phe Phe Ile Tyr Phe Pro Leu Cys Phe Gln 
        35                  40                  45              


Phe Asn Gln Thr Val Gly Thr Lys Met Ile Trp Val Ala Val Ile Gly 
    50                  55                  60                  


Asp Trp Leu Asn Leu Ile Phe Lys Trp His Ala Gly Gly Arg Gly Leu 
65                  70                  75                  80  


<210>  8672
<211>  5326
<212>  DNA
<213>  Homosapiens

<400>  8672
gaatgatgaa aaccgaggtt ggaaaaggtt gtgaaacctt ttaactctcc acagtggagt     60

ccattatttc ctctggcttc ctcaaattca tattcacagg gtcgttggct gtgggttgca    120

attaccatgt ctgactcagt aattcttcga agtataaaga aatttggaga ggagaatgat    180

ggttttgagt cagataaatc atataataat gataagaaat caaggttaca agatgagaag    240

aaaggtgatg gcgttagagt tggcttcttt caattgtttc ggttttcttc atcaactgac    300

atttggctga tgtttgtggg aagtttgtgt gcatttctcc atggaatagc ccagccaggc    360

gtgctactca tttttggcac aatgacagat gtttttattg actacgacgt tgagttacaa    420

gaactccaga ttccaggaaa agcatgtgtg aataacacca ttgtatggac taacagttcc    480

ctcaaccaga acatgacaaa tggaacacgt tgtgggttgc tgaacatcga gagcgaaatg    540

atcaaatttg ccagttacta tgctggaatt gctgtcgcag tacttatcac aggatatatt    600

caaatatgct tttgggtcat tgccgcagct cgtcagatac agaaaatgag aaaattttac    660

tttaggagaa taatgagaat ggaaataggg tggtttgact gcaattcagt gggggagctg    720

aatacaagat tctctgatga tattaataaa atcaatgatg ccatagctga ccaaatggcc    780

cttttcattc agcgcatgac ctcgaccatc tgtggtttcc tgttgggatt tttcaggggt    840

tggaaactga ccttggttat tatttctgtc agccctctca ttgggattgg agcagccacc    900

attggtctga gtgtgtccaa gtttacggac tatgagctga aggcctatgc caaagcaggg    960

gtggtggctg atgaagtcat ttcatcaatg agaacagtgg ctgcttttgg tggtgagaaa   1020

agagaggttg aaaggtatga gaaaaatctt gtgttcgccc agcgttgggg aattagaaaa   1080

ggaatagtga tgggattctt tactggattc gtgtggtgtc tcatcttttt gtgttatgca   1140

ctggccttct ggtacggctc cacacttgtc ctggatgaag gagaatatac accaggaacc   1200

cttgtccaga ttttcctcag tgtcatagta ggagctttaa atcttggcaa tgcctctcct   1260

tgtttggaag cctttgcaac tggacgtgca gcagccacca gcatttttga gacaatagac   1320

aggaaaccca tcattgactg catgtcagaa gatggttaca agttggatcg aatcaagggt   1380

gaaattgaat tccataatgt gaccttccat tatccttcca gaccagaggt gaagattcta   1440

aatgacctca acatggtcat taaaccaggg gaaatgacag ctctggtagg acccagtgga   1500

gctggaaaaa gtacagcact gcaactcatt cagcgattct atgacccctg tgaaggaatg   1560

gtgaccgtgg atggccatga cattcgctct cttaacattc agtggcttag agatcagatt   1620

gggatagtgg agcaagagcc agttctgttc tctaccacca ttgcagaaaa tattcgctat   1680

ggcagagaag atgcaacaat ggaagacata gtccaagctg ccaaggaggc caatgcctac   1740

aacttcatca tggacctgcc acagcaattt gacacccttg ttggagaagg aggaggccag   1800

atgagtggtg gccagaaaca aagggtagct atcgccagag ccctcatccg aaatcccaag   1860

attctgcttt tggacatggc cacctcagct ctggacaatg agagtgaagc catggtgcaa   1920

gaagtgctga gtaagattca gcatgggcac acaatcattt cagttgctca tcgcttgtct   1980

acggtcagag ctgcagatac catcattggt tttgaacatg gcactgcagt ggaaagaggg   2040

acccatgaag aattactgga aaggaaaggt gtttacttca ctctagtgac tttgcaaagc   2100

cagggaaatc aagctcttaa tgaagaggac ataaaggatg caactgaaga tgacatgctt   2160

gcgaggacct ttagcagagg gagctaccag gatagtttaa gggcttccat ccggcaacgc   2220

tccaagtctc agctttctta cctggtgcac gaacctccat tagctgttgt agatcataag   2280

tctacctatg aagaagatag aaaggacaag gacattcctg tgcaggaaga agttgaacct   2340

gccccagtta ggaggattct gaaattcagt gctccagaat ggccctacat gctggtaggg   2400

tctgtgggtg cagctgtgaa cgggacagtc acacccttgt atgccttttt attcagccag   2460

attcttggga ctttttcaat tcctgataaa gaggaacaaa ggtcacagat caatggtgtg   2520

tgcctacttt ttgtagcaat gggctgtgta tctcttttca cccaatttct acagggatat   2580

gcctttgcta aatctgggga gctcctaaca aaaaggctac gtaaatttgg tttcagggca   2640

atgctggggc aagatattgc ctggtttgat gacctcagaa atagccctgg agcattgaca   2700

acaagacttg ctacagatgc ttcccaagtt caaggggctg ccggctctca gatcgggatg   2760

atagtcaatt ccttcactaa cgtcactgtg gccatgatca ttgccttctc ctttagctgg   2820

aagctgagcc tggtcatctt gtgcttcttc cccttcttgg ctttatcagg agccacacag   2880

accaggatgt tgacaggatt tgcctctcga gataagcagg ccctggagat ggtgggacag   2940

attacaaatg aagccctcag taacatccgc actgttgctg gaattggaaa ggagaggcgg   3000

ttcattgaag cacttgagac tgagctggag aagcccttca agacagccat tcagaaagcc   3060

aatatttacg gattctgctt tgcctttgcc cagtgcatca tgtttattgc gaattctgct   3120

tcctacagat atggaggtta cttaatctcc aatgaggggc tccatttcag ctatgtgttc   3180

agggtgatct ctgcagttgt actgagtgca acagctcttg gaagagcctt ctcttacacc   3240

ccaagttatg caaaagctaa aatatcagct gcacgctttt ttcaactgct ggaccgacaa   3300

cccccaatca gtgtatacaa tactgcaggt gaaaaatggg acaacttcca ggggaagatt   3360

gattttgttg attgtaaatt tacatatcct tctcgacctg actcgcaagt tctgaatggt   3420

ctctcagtgt cgattagtcc agggcagaca ctggcgtttg ttgggagcag tggatgtggc   3480

aaaagcacta gcattcagct gttggaacgt ttctatgatc ctgatcaagg gaaggtgatg   3540

atagatggtc atgacagcaa aaaagtaaat gtccagttcc tccgctcaaa cattggaatt   3600

gtttcccagg aaccagtgtt gtttgcctgt agcataatgg acaatatcaa gtatggagac   3660

aacaccaaag aaattcccat ggaaagagtc atagcagctg caaaacaggc tcagctgcat   3720

gattttgtca tgtcactccc agagaaatat gaaactaacg ttgggtccca ggggtctcaa   3780

ctctctagag gggagaaaca acgcattgct attgctcggg ccattgtacg agatcctaaa   3840

atcttgctac tagatgaagc cacttctgcc ttagacacag aaagtgaaaa gacggtgcag   3900

gttgctctag acaaagccag agagggtcgg acctgcattg tcattgccca tcgcttgtcc   3960

accatccaga acgcggatat cattgctgtc atggcacagg gggtggtgat tgaaaagggg   4020

acccatgaag aactgatggc ccaaaaagga gcctactaca aactagtcac cactggatcc   4080

cccatcagtt gacccaatgc aagaatctca gacacacatg acgcaccagt tacaggggtt   4140

gtttttaaag aaaaaaacaa tcccagcagg agggattgct gggattgttt tttctttaaa   4200

gaagaatgtt aatattttac ttttacagtc attttcctac atcggaatcc aagctaattt   4260

ctaatggcct tccataataa ttctgcttta gatgtgtata cagaaaatga aagaaactag   4320

ggtccatatg agggaaaacc caatgtcaag tggcagctca gccaccactc agtgcttctc   4380

tgtgcaggag ccagtcctga ttaatatgtg ggaattagtg agacatcagg gagtaagtga   4440

cactttgaac tcctcaaggg cagagaactg tctttcattt ttgaaccctc ggtgtacaca   4500

gaggcgggtc tataacaggc aatcaacaaa cgtttcttga gctagaccaa ggtcagattt   4560

gaaaagaaca gaaggactga agaccagctg tgtttcttaa ctaaatttgt ctttcaagtg   4620

aaaccagctt ccttcatctc taaggctaag gatagggaaa gggtggatgc tctcaggctg   4680

agggaggcag aaagggaaag tattagcatg agctttccag ttagggctgt tgatttatgc   4740

tttaacttca gagtgagtgt aggggtggtg atgctaccat tactgtgagg acctaccagt   4800

gtggctggag cagggactct ctcccaggcc ttttactcct cagcacctcc ctgcatactg   4860

attgttgttt ttagtttctg tgaaattata ttcatgaaat gaaaatagcg cattttactt   4920

tgctgtagtt tcataaggtt ttatacaaaa aagcaagtaa atatggcaga aaagcactca   4980

tttgcccctg ctccctcaaa acaccacaga atgacataga actaaaggcg gcaggaatct   5040

acaagaatga agaaaacaca gtgatgccac ctgcaaaatc ttgggagcca gaaagcaaat   5100

ggacaattga taatagagtt acaagatgag agaaaacaaa aatgtaacct gttagttggg   5160

ggagcctaga aacatcctgt tttgtaccac agacccctag aaagtttcaa gatgtaaaaa   5220

cactggatcc ttctggaagg aggagacaag gggacagagg gactgaagac agaagaatgg   5280

accaaaagcc tgtatggaaa cagaattgca gagccccgcc tgcagc                  5326


<210>  8673
<211>  1321
<212>  PRT
<213>  Homosapiens

<400>  8673

Met Ser Asp Ser Val Ile Leu Arg Ser Ile Lys Lys Phe Gly Glu Glu 
1               5                   10                  15      


Asn Asp Gly Phe Glu Ser Asp Lys Ser Tyr Asn Asn Asp Lys Lys Ser 
            20                  25                  30          


Arg Leu Gln Asp Glu Lys Lys Gly Asp Gly Val Arg Val Gly Phe Phe 
        35                  40                  45              


Gln Leu Phe Arg Phe Ser Ser Ser Thr Asp Ile Trp Leu Met Phe Val 
    50                  55                  60                  


Gly Ser Leu Cys Ala Phe Leu His Gly Ile Ala Gln Pro Gly Val Leu 
65                  70                  75                  80  


Leu Ile Phe Gly Thr Met Thr Asp Val Phe Ile Asp Tyr Asp Val Glu 
                85                  90                  95      


Leu Gln Glu Leu Gln Ile Pro Gly Lys Ala Cys Val Asn Asn Thr Ile 
            100                 105                 110         


Val Trp Thr Asn Ser Ser Leu Asn Gln Asn Met Thr Asn Gly Thr Arg 
        115                 120                 125             


Cys Gly Leu Leu Asn Ile Glu Ser Glu Met Ile Lys Phe Ala Ser Tyr 
    130                 135                 140                 


Tyr Ala Gly Ile Ala Val Ala Val Leu Ile Thr Gly Tyr Ile Gln Ile 
145                 150                 155                 160 


Cys Phe Trp Val Ile Ala Ala Ala Arg Gln Ile Gln Lys Met Arg Lys 
                165                 170                 175     


Phe Tyr Phe Arg Arg Ile Met Arg Met Glu Ile Gly Trp Phe Asp Cys 
            180                 185                 190         


Asn Ser Val Gly Glu Leu Asn Thr Arg Phe Ser Asp Asp Ile Asn Lys 
        195                 200                 205             


Ile Asn Asp Ala Ile Ala Asp Gln Met Ala Leu Phe Ile Gln Arg Met 
    210                 215                 220                 


Thr Ser Thr Ile Cys Gly Phe Leu Leu Gly Phe Phe Arg Gly Trp Lys 
225                 230                 235                 240 


Leu Thr Leu Val Ile Ile Ser Val Ser Pro Leu Ile Gly Ile Gly Ala 
                245                 250                 255     


Ala Thr Ile Gly Leu Ser Val Ser Lys Phe Thr Asp Tyr Glu Leu Lys 
            260                 265                 270         


Ala Tyr Ala Lys Ala Gly Val Val Ala Asp Glu Val Ile Ser Ser Met 
        275                 280                 285             


Arg Thr Val Ala Ala Phe Gly Gly Glu Lys Arg Glu Val Glu Arg Tyr 
    290                 295                 300                 


Glu Lys Asn Leu Val Phe Ala Gln Arg Trp Gly Ile Arg Lys Gly Ile 
305                 310                 315                 320 


Val Met Gly Phe Phe Thr Gly Phe Val Trp Cys Leu Ile Phe Leu Cys 
                325                 330                 335     


Tyr Ala Leu Ala Phe Trp Tyr Gly Ser Thr Leu Val Leu Asp Glu Gly 
            340                 345                 350         


Glu Tyr Thr Pro Gly Thr Leu Val Gln Ile Phe Leu Ser Val Ile Val 
        355                 360                 365             


Gly Ala Leu Asn Leu Gly Asn Ala Ser Pro Cys Leu Glu Ala Phe Ala 
    370                 375                 380                 


Thr Gly Arg Ala Ala Ala Thr Ser Ile Phe Glu Thr Ile Asp Arg Lys 
385                 390                 395                 400 


Pro Ile Ile Asp Cys Met Ser Glu Asp Gly Tyr Lys Leu Asp Arg Ile 
                405                 410                 415     


Lys Gly Glu Ile Glu Phe His Asn Val Thr Phe His Tyr Pro Ser Arg 
            420                 425                 430         


Pro Glu Val Lys Ile Leu Asn Asp Leu Asn Met Val Ile Lys Pro Gly 
        435                 440                 445             


Glu Met Thr Ala Leu Val Gly Pro Ser Gly Ala Gly Lys Ser Thr Ala 
    450                 455                 460                 


Leu Gln Leu Ile Gln Arg Phe Tyr Asp Pro Cys Glu Gly Met Val Thr 
465                 470                 475                 480 


Val Asp Gly His Asp Ile Arg Ser Leu Asn Ile Gln Trp Leu Arg Asp 
                485                 490                 495     


Gln Ile Gly Ile Val Glu Gln Glu Pro Val Leu Phe Ser Thr Thr Ile 
            500                 505                 510         


Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asp Ala Thr Met Glu Asp Ile 
        515                 520                 525             


Val Gln Ala Ala Lys Glu Ala Asn Ala Tyr Asn Phe Ile Met Asp Leu 
    530                 535                 540                 


Pro Gln Gln Phe Asp Thr Leu Val Gly Glu Gly Gly Gly Gln Met Ser 
545                 550                 555                 560 


Gly Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ile Arg Asn 
                565                 570                 575     


Pro Lys Ile Leu Leu Leu Asp Met Ala Thr Ser Ala Leu Asp Asn Glu 
            580                 585                 590         


Ser Glu Ala Met Val Gln Glu Val Leu Ser Lys Ile Gln His Gly His 
        595                 600                 605             


Thr Ile Ile Ser Val Ala His Arg Leu Ser Thr Val Arg Ala Ala Asp 
    610                 615                 620                 


Thr Ile Ile Gly Phe Glu His Gly Thr Ala Val Glu Arg Gly Thr His 
625                 630                 635                 640 


Glu Glu Leu Leu Glu Arg Lys Gly Val Tyr Phe Thr Leu Val Thr Leu 
                645                 650                 655     


Gln Ser Gln Gly Asn Gln Ala Leu Asn Glu Glu Asp Ile Lys Asp Ala 
            660                 665                 670         


Thr Glu Asp Asp Met Leu Ala Arg Thr Phe Ser Arg Gly Ser Tyr Gln 
        675                 680                 685             


Asp Ser Leu Arg Ala Ser Ile Arg Gln Arg Ser Lys Ser Gln Leu Ser 
    690                 695                 700                 


Tyr Leu Val His Glu Pro Pro Leu Ala Val Val Asp His Lys Ser Thr 
705                 710                 715                 720 


Tyr Glu Glu Asp Arg Lys Asp Lys Asp Ile Pro Val Gln Glu Glu Val 
                725                 730                 735     


Glu Pro Ala Pro Val Arg Arg Ile Leu Lys Phe Ser Ala Pro Glu Trp 
            740                 745                 750         


Pro Tyr Met Leu Val Gly Ser Val Gly Ala Ala Val Asn Gly Thr Val 
        755                 760                 765             


Thr Pro Leu Tyr Ala Phe Leu Phe Ser Gln Ile Leu Gly Thr Phe Ser 
    770                 775                 780                 


Ile Pro Asp Lys Glu Glu Gln Arg Ser Gln Ile Asn Gly Val Cys Leu 
785                 790                 795                 800 


Leu Phe Val Ala Met Gly Cys Val Ser Leu Phe Thr Gln Phe Leu Gln 
                805                 810                 815     


Gly Tyr Ala Phe Ala Lys Ser Gly Glu Leu Leu Thr Lys Arg Leu Arg 
            820                 825                 830         


Lys Phe Gly Phe Arg Ala Met Leu Gly Gln Asp Ile Ala Trp Phe Asp 
        835                 840                 845             


Asp Leu Arg Asn Ser Pro Gly Ala Leu Thr Thr Arg Leu Ala Thr Asp 
    850                 855                 860                 


Ala Ser Gln Val Gln Gly Ala Ala Gly Ser Gln Ile Gly Met Ile Val 
865                 870                 875                 880 


Asn Ser Phe Thr Asn Val Thr Val Ala Met Ile Ile Ala Phe Ser Phe 
                885                 890                 895     


Ser Trp Lys Leu Ser Leu Val Ile Leu Cys Phe Phe Pro Phe Leu Ala 
            900                 905                 910         


Leu Ser Gly Ala Thr Gln Thr Arg Met Leu Thr Gly Phe Ala Ser Arg 
        915                 920                 925             


Asp Lys Gln Ala Leu Glu Met Val Gly Gln Ile Thr Asn Glu Ala Leu 
    930                 935                 940                 


Ser Asn Ile Arg Thr Val Ala Gly Ile Gly Lys Glu Arg Arg Phe Ile 
945                 950                 955                 960 


Glu Ala Leu Glu Thr Glu Leu Glu Lys Pro Phe Lys Thr Ala Ile Gln 
                965                 970                 975     


Lys Ala Asn Ile Tyr Gly Phe Cys Phe Ala Phe Ala Gln Cys Ile Met 
            980                 985                 990         


Phe Ile Ala Asn Ser Ala Ser Tyr  Arg Tyr Gly Gly Tyr  Leu Ile Ser 
        995                 1000                 1005             


Asn Glu  Gly Leu His Phe Ser  Tyr Val Phe Arg Val  Ile Ser Ala 
    1010                 1015                 1020             


Val Val  Leu Ser Ala Thr Ala  Leu Gly Arg Ala Phe  Ser Tyr Thr 
    1025                 1030                 1035             


Pro Ser  Tyr Ala Lys Ala Lys  Ile Ser Ala Ala Arg  Phe Phe Gln 
    1040                 1045                 1050             


Leu Leu  Asp Arg Gln Pro Pro  Ile Ser Val Tyr Asn  Thr Ala Gly 
    1055                 1060                 1065             


Glu Lys  Trp Asp Asn Phe Gln  Gly Lys Ile Asp Phe  Val Asp Cys 
    1070                 1075                 1080             


Lys Phe  Thr Tyr Pro Ser Arg  Pro Asp Ser Gln Val  Leu Asn Gly 
    1085                 1090                 1095             


Leu Ser  Val Ser Ile Ser Pro  Gly Gln Thr Leu Ala  Phe Val Gly 
    1100                 1105                 1110             


Ser Ser  Gly Cys Gly Lys Ser  Thr Ser Ile Gln Leu  Leu Glu Arg 
    1115                 1120                 1125             


Phe Tyr  Asp Pro Asp Gln Gly  Lys Val Met Ile Asp  Gly His Asp 
    1130                 1135                 1140             


Ser Lys  Lys Val Asn Val Gln  Phe Leu Arg Ser Asn  Ile Gly Ile 
    1145                 1150                 1155             


Val Ser  Gln Glu Pro Val Leu  Phe Ala Cys Ser Ile  Met Asp Asn 
    1160                 1165                 1170             


Ile Lys  Tyr Gly Asp Asn Thr  Lys Glu Ile Pro Met  Glu Arg Val 
    1175                 1180                 1185             


Ile Ala  Ala Ala Lys Gln Ala  Gln Leu His Asp Phe  Val Met Ser 
    1190                 1195                 1200             


Leu Pro  Glu Lys Tyr Glu Thr  Asn Val Gly Ser Gln  Gly Ser Gln 
    1205                 1210                 1215             


Leu Ser  Arg Gly Glu Lys Gln  Arg Ile Ala Ile Ala  Arg Ala Ile 
    1220                 1225                 1230             


Val Arg  Asp Pro Lys Ile Leu  Leu Leu Asp Glu Ala  Thr Ser Ala 
    1235                 1240                 1245             


Leu Asp  Thr Glu Ser Glu Lys  Thr Val Gln Val Ala  Leu Asp Lys 
    1250                 1255                 1260             


Ala Arg  Glu Gly Arg Thr Cys  Ile Val Ile Ala His  Arg Leu Ser 
    1265                 1270                 1275             


Thr Ile  Gln Asn Ala Asp Ile  Ile Ala Val Met Ala  Gln Gly Val 
    1280                 1285                 1290             


Val Ile  Glu Lys Gly Thr His  Glu Glu Leu Met Ala  Gln Lys Gly 
    1295                 1300                 1305             


Ala Tyr  Tyr Lys Leu Val Thr  Thr Gly Ser Pro Ile  Ser 
    1310                 1315                 1320     


<210>  8674
<211>  698
<212>  DNA
<213>  Homosapiens

<400>  8674
ggttgaagcc tccatttccc tgtctaggag cttctgttta cactccaccc cactctagat     60

tgcaagcccc ttgaataatt tttgtttcct agtaccaaga ataatggtga caaatattag    120

gggatgactc ctaaaaatgg attaagaagc tatttagggg gaaaatgccc attttgtggt    180

tttaaaagat gctacaattg ccataaaatg cccaagtttc attgcagaaa tcaaatactg    240

gagttgtgtt ttgcttggtc aagaggaaag aatgtacatt tagagacaaa gaatcgctgt    300

ggcagttaac tttggtgtta cattctgttt tcttcctaag caattcttta gtcctctacc    360

tcaacggtgc ctctgaagaa aggacttacg tggccaatgg gatcaccgtg tatttatttc    420

ccttccctat cagccatagc cctcagggct ggaagggcct cattttagtc tattcccaga    480

ctgggtcacc cacagtgttg acacacagca tcaaccgaca gtgagcttat ctggaaaata    540

atgcctttct attttctttg tttcttagca tatattaaat gtttctttcc ttctctaata    600

atcttttaga taaagaaatc atttgctgag ctgataataa caaaagtatc ctacctacat    660

ttttaaatgt cagcagtgaa agacgtttta agggcttt                            698


<210>  8675
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  8675

Met Thr Pro Lys Asn Gly Leu Arg Ser Tyr Leu Gly Gly Lys Cys Pro 
1               5                   10                  15      


Phe Cys Gly Phe Lys Arg Cys Tyr Asn Cys His Lys Met Pro Lys Phe 
            20                  25                  30          


His Cys Arg Asn Gln Ile Leu Glu Leu Cys Phe Ala Trp Ser Arg Gly 
        35                  40                  45              


Lys Asn Val His Leu Glu Thr Lys Asn Arg Cys Gly Ser 
    50                  55                  60      


<210>  8676
<211>  2865
<212>  DNA
<213>  Homosapiens

<400>  8676
atctgaaaaa ttaataattc cttaattatc aaatatccat tatttaaatt tataattgtg     60

tcataaatat tgtcataaat agatttgctg ttttaaagct tgttccttca ttttctctgt    120

tttgttttag ataaacattg tcataaatag atttgttgtt ttaaagcttg ttccttcatt    180

ttctctgatt gttttgtttt agattcagag gttacttatg cttgtttgtt acatggatgt    240

tacatgtgta atgggggata ttggacttct agtgtactca tcacccatat actgaacact    300

gtactcaaaa gggattgaaa gaaactagga aacttggcag gaagatcatt cttaagccag    360

gaaaaaaatt tttaatgctc acatgtgaac atgtgatggt cataccagaa ggagcaccca    420

cctccctccc tctgtgacag acacattttc ttagccttca cctttccttc tttcaagttg    480

ctgaaaatcc acagtgtttc tgttcatttg ttactttcat tctcacctat cttctctctt    540

gctccatcta ccagaacaat aattccccat ataatacttc tcacttcact tttcaacgca    600

ggacctcttg ttgggtctga tctgtttgtc tgtccgcttt atcaatatta tcagatgtaa    660

gtttacatga atacacacac atattcacta aactgagggg aaaaaatgcc ttgtaggtca    720

taaaaaagca gggaaattcc caacaattca tatttgatcc ctggatccag gggtggcagc    780

aataagcctg ctttagatat ttactcccca ttttatgatc cggtggtttg gtttttcaaa    840

tgatgatatg gctcctttcg caatgacttg atgtttagga ggtgtgcttc aataaataca    900

ttttaaaatc aacaatcaag ttagagttgt acaaatggct ctgaaatgtc ccactacact    960

gttagaccaa gggcacagat tgtgcttctg tactatttat cctagtatcc ctcggcatat   1020

attaactgct ctaaaaatct ccttggctac acgctgcatc aaatcaaagt taaatgttat   1080

accacctttc tattctattt ttaatattca aagagggtgc tcagatttta gaacaaattt   1140

caatgtttaa gtacacacaa aaaaatcatt aactcatata tttcaagagt aggaaatggg   1200

aactggtgtt aaaactctta taacaaatgt cactgtctta agggacagtg tttaaaaacg   1260

catacctggc cgggcgcggt ggctcatgcc tgtaatccca gcactttggg aggccgaggc   1320

cggcggatca caaggaaaac aaactcagga agaaaaagaa aagcagaagt gatcaaggag   1380

agcgctcgag ttgcaatatt ttcctttggc tgctgacagg cagttactat aaagcattgt   1440

gcatggacac catcttcttg tattatacaa gaaaggagtg tacctatcac acacaggggg   1500

aaaaatgctc ttttgggtgc taggcctcct aatcctctgt ggttttctgt ggactcgtaa   1560

aggaaaacta aagattgaag acatcactga taagtacatt tttatcactg gatgtgactc   1620

gggctttgga aacttggcag ccagaacttt tgataaaaag ggatttcatg taatcgctgc   1680

ctgtctgact gaatcaggat caacagcttt aaaggcagaa acctcagaga gacttcgtac   1740

tgtgcttctg gatgtgaccg acccagagaa tgtcaagagg actgcccagt gggtgaagaa   1800

ccaagttggg gagaaaggtc tctggggtct gatcaataat gctggtgttc ccggcgtgct   1860

ggctcccact gactggctga cactagagga ctacagagaa cctattgaag tgaacctgtt   1920

tggactcatc agtgtgacac taaatatgct tcctttggtc aagaaagctc aagggagagt   1980

tattaatgtc tccagtgttg gaggtcgcct tgcaatcgtt ggagggggct atactccatc   2040

caaatatgca gtggaaggtt tcaatgacag cttaagacgg gacatgaaag cttttggtgt   2100

gcacgtctca tgcattgaac caggattgtt caaaacaaac ttggcagatc cagtaaaggt   2160

aattgaaaaa aaactcgcca tttgggagca gctgtctcca gacatcaaac aacaatatgg   2220

agaaggttac attgaaaaaa gtctagacaa actgaaaggc aataaatcct atgtgaacat   2280

ggacctctct ccggtggtag agtgcatgga ccacgctcta acaagtctct tccctaagac   2340

tcattatgcc gctggaaaag atgccaaaat tttctggata cctctgtctc acatgccagc   2400

agctttgcaa gactttttat tgttgaaaca gaaagcagag ctggctaatc ccaaggcagt   2460

gtgactcagc taaccacaaa tgtctcctcc aggctatgaa attggccgat ttcaagaaca   2520

catctccttt tcaaccccat tccttatctg ctccaacctg gactcattta gatcgtgctt   2580

atttggattg caaaagggag tcccaccatc gctggtggta tcccagggtc cctgctcaag   2640

ttttctttga aaaggagggc tggaatggta catcacatag gcaagtcctg ccctgtattt   2700

aggctttgcc tgcttggtgt gatgtaaggg aaattgaaag acttgcccat tcaaaatgat   2760

ctttaccgtg gcctgcccca tgcttatggt ccccagcatt tacagtaact tgtgaatgtt   2820

aagtatcatc tcttatctaa atattaaaag ataagtcaaa cattt                   2865


<210>  8677
<211>  319
<212>  PRT
<213>  Homosapiens

<400>  8677

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  8678
<211>  1918
<212>  DNA
<213>  Homosapiens

<400>  8678
aggaagaaaa tataaagtac acttttaaaa catgaagtct tcatagcagc ttatagtcgt     60

tcagagaaac atgttccact gagaatgact tgagagagag gattacatca ttatgccaga    120

aggaagaagc cactgtgcat gctctatcac cagcctcacc ctcctggtca gccttacaag    180

agtgacactg gatatactcc agaagttgga cccaccacag cctgcacact ggacttcttg    240

gcttttatga gctattcaag agatatttag tcatcacgtt gtgtcacaat gggagtgact    300

cacagagcaa ggagagaacc tgaggattcc tcacacatgt agtactcaga gctctacgga    360

aacccaggca cctcgacctc aagaggatca gcctggccag ggtggcacaa ctcttccttc    420

cccgtgcaca gcaggaaagc tgccatcagc tgagcaagtc caccaacagt ttctgtgtcc    480

cacttcatct ttaataagga caccatcttc ttgtattata caagaaagga gtgtacctat    540

cacacacagg gggaaaaatg ctcttttggg tgctaggcct cctaatcctc tgtggttttc    600

tgtggactcg taaaggaaaa ctaaagattg aagacatcac tgataagtac atttttatca    660

ctggatgtga ctcgggcttt ggaaacttgg cagccagaac ttttgataaa aagggatttc    720

atgtaatcgc tgcctgtctg actgaatcag gatcaacagc tttaaaggca gaaacctcag    780

agagacttcg tactgtgctt ctggatgtga ccgacccaga gaatgtcaag aggactgccc    840

agtgggtgaa gaaccaagtt ggggagaaag gtctctgggg tctgatcaat aatgctggtg    900

ttcccggcgt gctggctccc actgactggc tgacactaga ggactacaga gaacctattg    960

aagtgaacct gtttggactc atcagtgtga cactaaatat gcttcctttg gtcaagaaag   1020

ctcaagggag agttattaat gtctccagtg ttggaggtcg ccttgcaatc gttggagggg   1080

gctatactcc atccaaatat gcagtggaag gtttcaatga cagcttaaga cgggacatga   1140

aagcttttgg tgtgcacgtc tcatgcattg aaccaggatt gttcaaaaca aacttggcag   1200

atccagtaaa ggtaattgaa aaaaaactcg ccatttggga gcagctgtct ccagacatca   1260

aacaacaata tggagaaggt tacattgaaa aaagtctaga caaactgaaa ggcaataaat   1320

cctatgtgaa catggacctc tctccggtgg tagagtgcat ggaccacgct ctaacaagtc   1380

tcttccctaa gactcattat gccgctggaa aagatgccaa aattttctgg atacctctgt   1440

ctcacatgcc agcagctttg caagactttt tattgttgaa acagaaagca gagctggcta   1500

atcccaaggc agtgtgactc agctaaccac aaatgtctcc tccaggctat gaaattggcc   1560

gatttcaaga acacatctcc ttttcaaccc cattccttat ctgctccaac ctggactcat   1620

ttagatcgtg cttatttgga ttgcaaaagg gagtcccacc atcgctggtg gtatcccagg   1680

gtccctgctc aagttttctt tgaaaaggag ggctggaatg gtacatcaca taggcaagtc   1740

ctgccctgta tttaggcttt gcctgcttgg tgtgatgtaa gggaaattga aagacttgcc   1800

cattcaaaat gatctttacc gtggcctgcc ccatgcttat ggtccccagc atttacagta   1860

acttgtgaat gttaagtatc atctcttatc taaatattaa aagataagtc aaacattt     1918


<210>  8679
<211>  319
<212>  PRT
<213>  Homosapiens

<400>  8679

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  8680
<211>  581
<212>  DNA
<213>  Homosapiens

<400>  8680
atagcagctt atagtcgttc agagaaacat gttccactga gaatgacttg agagagagga     60

ttacatcatt atgccagaag gaagaagcca ctgtgcatgc tctatcacca gcctcaccct    120

cctggtcagc cttacaagag tgacactgga tatactccag aagttggacc caccacagcc    180

tgcacactgg acttcttggc ttttatgagc tattcaagag atatttagtc atcacgttgt    240

gtcacaatgg gagtgactca cagagcaagg agagaacctg aggattcctc acacatgtag    300

tactcagagc tctacggaaa cccaggcacc tcgacctcaa gaggatcagc ctggccaggg    360

tggcacaact cttccttccc cgtgcacagc aggaaagctg ccatcagctg agcaagtcca    420

ccaacagttt ctgtgtccca cttcatcttt aataaggaca ccatcttctt gtattataca    480

agaaaggagt gtacctatca cacacagggg gaaaaatgct cttttgggtg ctaggcctcc    540

taatcctctg tggttttctg tggactcgta aaggaaaact a                        581


<210>  8681
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  8681

Met Pro Glu Gly Arg Ser His Cys Ala Cys Ser Ile Thr Ser Leu Thr 
1               5                   10                  15      


Leu Leu Val Ser Leu Thr Arg Val Thr Leu Asp Ile Leu Gln Lys Leu 
            20                  25                  30          


Asp Pro Pro Gln Pro Ala His Trp Thr Ser Trp Leu Leu 
        35                  40                  45  


<210>  8682
<211>  1808
<212>  DNA
<213>  Homosapiens

<400>  8682
aagaaacaga ggaaggtgaa taagagaagt gaaattaaat aatcctattt taactttttt     60

actaggaaaa caaactcagg aagaaaaaga aaagcagaag tgatcaagga gagcgctcga    120

gttgcaatat tttcctttgg ctgctgacag gcagttacta taaagcattg tgcatggtag    180

gaaaatggag gctaagaaaa gttaatttgt ccgagggccc tctgatgata gtgaaactgg    240

gatggaacct ctgcctgctt gcttctgagg tctgggctcc taactactgc tctactgcct    300

cgagccaaga gatttacgcc ctattaagca atttgttgtg cgataaattg gaagacacag    360

cagataagca aacaactcaa gcaaccagga caccatcttc ttgtattata caagaaagga    420

gtgtacctat cacacacagg gggaaaaatg ctcttttggg tgctaggcct cctaatcctc    480

tgtggttttc tgtggactcg taaaggaaaa ctaaagattg aagacatcac tgataagtac    540

atttttatca ctggatgtga ctcgggcttt ggaaacttgg cagccagaac ttttgataaa    600

aagggatttc atgtaatcgc tgcctgtctg actgaatcag gatcaacagc tttaaaggca    660

gaaacctcag agagacttcg tactgtgctt ctggatgtga ccgacccaga gaatgtcaag    720

aggactgccc agtgggtgaa gaaccaagtt ggggagaaag gtctctgggg tctgatcaat    780

aatgctggtg ttcccggcgt gctggctccc actgactggc tgacactaga ggactacaga    840

gaacctattg aagtgaacct gtttggactc atcagtgtga cactaaatat gcttcctttg    900

gtcaagaaag ctcaagggag agttattaat gtctccagtg ttggaggtcg ccttgcaatc    960

gttggagggg gctatactcc atccaaatat gcagtggaag gtttcaatga cagcttaaga   1020

cgggacatga aagcttttgg tgtgcacgtc tcatgcattg aaccaggatt gttcaaaaca   1080

aacttggcag atccagtaaa ggtaattgaa aaaaaactcg ccatttggga gcagctgtct   1140

ccagacatca aacaacaata tggagaaggt tacattgaaa aaagtctaga caaactgaaa   1200

ggcaataaat cctatgtgaa catggacctc tctccggtgg tagagtgcat ggaccacgct   1260

ctaacaagtc tcttccctaa gactcattat gccgctggaa aagatgccaa aattttctgg   1320

atacctctgt ctcacatgcc agcagctttg caagactttt tattgttgaa acagaaagca   1380

gagctggcta atcccaaggc agtgtgactc agctaaccac aaatgtctcc tccaggctat   1440

gaaattggcc gatttcaaga acacatctcc ttttcaaccc cattccttat ctgctccaac   1500

ctggactcat ttagatcgtg cttatttgga ttgcaaaagg gagtcccacc atcgctggtg   1560

gtatcccagg gtccctgctc aagttttctt tgaaaaggag ggctggaatg gtacatcaca   1620

taggcaagtc ctgccctgta tttaggcttt gcctgcttgg tgtgatgtaa gggaaattga   1680

aagacttgcc cattcaaaat gatctttacc gtggcctgcc ccatgcttat ggtccccagc   1740

atttacagta acttgtgaat gttaagtatc atctcttatc taaatattaa aagataagtc   1800

aaacattt                                                            1808


<210>  8683
<211>  319
<212>  PRT
<213>  Homosapiens

<400>  8683

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  8684
<211>  1105
<212>  DNA
<213>  Homosapiens

<400>  8684
aaaggtggca aataagtact gtcttaccac acctcttttc cttcctctct gttctaggtc     60

tctggggtct gatcaataat gctggtgttc ccggcgtgct ggctcccact gactggctga    120

cactagagga ctacagagaa cctattgaag tgaacctgtt tggactcatc agtgtgacac    180

taaatatgct tcctttggtc aagaaagctc aagggagagt tattaatgtc tccagtgttg    240

gaggtcgcct tgcaatcgtt ggagggggct atactccatc caaatatgca gtggaaggtt    300

tcaatgacag cttaagacgg gacatgaaag cttttggtgt gcacgtctca tgcattgaac    360

caggattgtt caaaacaaac ttggcagatc cagtaaaggt aattgaaaaa aaactcgcca    420

tttgggagca gctgtctcca gacatcaaac aacaatatgg agaaggttac attgaaaaaa    480

gtctagacaa actgaaaggc aataaatcct atgtgaacat ggacctctct ccggtggtag    540

agtgcatgga ccacgctcta acaagtctct tccctaagac tcattatgcc gctggaaaag    600

atgccaaaat tttctggata cctctgtctc acatgccagc agctttgcaa gactttttat    660

tgttgaaaca gaaagcagag ctggctaatc ccaaggcagt gtgactcagc taaccacaaa    720

tgtctcctcc aggctatgaa attggccgat ttcaagaaca catctccttt tcaaccccat    780

tccttatctg ctccaacctg gactcattta gatcgtgctt atttggattg caaaagggag    840

tcccaccatc gctggtggta tcccagggtc cctgctcaag ttttctttga aaaggagggc    900

tggaatggta catcacatag gcaagtcctg ccctgtattt aggctttgcc tgcttggtgt    960

gatgtaaggg aaattgaaag acttgcccat tcaaaatgat ctttaccgtg gcctgcccca   1020

tgcttatggt ccccagcatt tacagtaact tgtgaatgtt aagtatcatc tcttatctaa   1080

atattaaaag ataagtcaaa cattt                                         1105


<210>  8685
<211>  172
<212>  PRT
<213>  Homosapiens

<400>  8685

Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile Asn Val Ser 
1               5                   10                  15      


Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr Thr Pro Ser 
            20                  25                  30          


Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg Asp Met Lys 
        35                  40                  45              


Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu Phe Lys Thr 
    50                  55                  60                  


Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu Ala Ile Trp 
65                  70                  75                  80  


Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu Gly Tyr Ile 
                85                  90                  95      


Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr Val Asn Met 
            100                 105                 110         


Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu Thr Ser Leu 
        115                 120                 125             


Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys Ile Phe Trp 
    130                 135                 140                 


Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe Leu Leu Leu 
145                 150                 155                 160 


Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
                165                 170         


<210>  8686
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  8686
cggtgcggtg tgctacgcgc gcccacctcc cggggaagga acggcgaggc cggggaccgt     60

cgcggagatg gatcgcgggc cggcagcagt ggcgtgcacg ctgctcctgg ctctcgtcgc    120

ctgcctagcg ccggccagtg gccaagaatg tgacagtgcg cattttcgct gtggaagtgg    180

gcattgcatc cctgcagact ggaggtgtga tgggaccaaa gactgttcag atgacgcgga    240

tgaaattggc tgcgctgttg tgacctgcca gcagggctat ttcaagtgcc agagtgaggg    300

acaatgcatc cccaactcct gggtgtgtga ccaagatcaa gactgtgatg atggctcaga    360

tgaacgtcaa gattgctcac aaagtacatg ctcaagtcat cagataacat gctccaatgg    420

tcagtgtatc ccaagtgaat acaggtgcga ccacgtcaga gactgccccg atggagctga    480

tgagaatgac tgccagtacc caacatgtga gcagcttact tgtgacaatg gggcctgcta    540

taacaccagt cagaagtgtg attggaaagt tgattgcagg gactcctcag atgaaatcaa    600

ctgcactgag atatgcttgc acaatgagtt ttcatgtggc aatggagagt gtatccctcg    660

tgcttatgtc tgtgaccatg acaatgattg ccaagacggc agtgacgaac atgcttgcaa    720

ctatccgacc tgcggtggtt accagttcac ttgccccagt ggccgatgca tttatcaaaa    780

ctgggtttgt gatggagaag atgactgtaa agataatgga gatgaagatg gatgtgaaag    840

cggtcctcat gatgttcata aatgttcccc aagagaatgg tcttgcccag agtcgggacg    900

atgcatctcc atttataaag tttgtgatgg gattttagat tgcccaggaa gagaagatga    960

aaacaacact agtaccggaa aatactgtag tatgactctg tgctctgcct tgaactgcca   1020

gtaccagtgc catgagacgc cgtatggagg agcgtgtttt tgtcccccag gttatatcat   1080

caaccacaat gacagccgta cctgtgttga gtttgatgat tgccagatat ggggaatttg   1140

tgaccagaag tgtgaaagcc gacctggccg tcacctgtgc cactgtgaag aagggtatat   1200

cttggagcgt ggacagtatt gcaaagctaa tgattccttt ggcgaggcct ccattatctt   1260

ctccaatggt cgggatttgt taattggtga tattcatgga aggagcttcc ggatcctagt   1320

ggagtctcag aatcgtggag tggccgtggg tgtggctttc cactatcacc tgcaaagagt   1380

tttttggaca gacaccgtgc aaaataaggt tttttcagtt gacattaatg gtttaaatat   1440

ccaagaggtt ctcaatgttt ctgttgaaac cccagagaac ctggctgtgg actgggttaa   1500

taataaaatc tatctagtgg aaaccaaggt caaccgcata gatatggtaa atttggatgg   1560

aagctatcgg gttaccctta taactgaaaa cttggggcat cctagaggaa ttgccgtgga   1620

cccaactgtt ggttatttat ttttctcaga ttgggagagc ctttctgggg aacctaagct   1680

ggaaagggca ttcatggatg gcagcaaccg taaagacttg gtgaaaacaa agctgggatg   1740

gcctgctggg gtaactctgg atatgatatc gaagcgtgtt tactgggttg actctcggtt   1800

tgattacatt gaaactgtaa cttatgatgg aattcaaagg aagactgtag ttcatggagg   1860

ctccctcatt cctcatccct ttggagtaag cttatttgaa ggtcaggtgt tctttacaga   1920

ttggacaaag atggccgtgc tgaaggcaaa caagttcaca gagaccaacc cacaagtgta   1980

ctaccaggct tccctgaggc cctatggagt gactgtttac cattccctca gacagcccta   2040

tgctaccaat ccgtgtaaag ataacaatgg gggctgtgag caggtctgtg tcctcagcca   2100

cagaacagat aatgatggtt tgggtttccg ttgcaagtgc acattcggct tccaactgga   2160

tacagatgag cgccactgca ttgctgttca gaatttcctc attttttcat cccaagttgc   2220

tattcgtggg atcccgttca ccttgtctac ccaggaagat gtcatggttc cagtttcggg   2280

gaatccttct ttctttgtcg ggattgattt tgacgcccag gacagcacta tctttttttc   2340

agatatgtca aaacacatga tttttaagca aaagattgat ggcacaggaa gagaaattct   2400

cgcagctaac agggtggaaa atgttgaaag tttggctttt gattggattt caaagaatct   2460

ctattggaca gactctcatt acaagagtat cagtgtcatg aggctagctg ataaaacgag   2520

acgcacagta gttcagtatt taaataaccc acggtcggtg gtagttcatc cttttgccgg   2580

gtatctattc ttcactgatt ggttccgtcc tgctaaaatt atgagagcat ggagtgacgg   2640

atctcacctc ttgcctgtaa taaacactac tcttggatgg cccaatggct tggccatcga   2700

ttgggctgct tcacgattgt actgggtaga tgcctatttt gataaaattg agcacagcac   2760

ctttgatggt ttagacagaa gaagactggg ccatatagag cagatgacac atccgtttgg   2820

acttgccatc tttggagagc atttattttt tactgactgg agactgggtg ccattattcg   2880

agtcaggaaa gcagatggtg gagaaatgac agttatccga agtggcattg cttacatact   2940

gcatttgaaa tcgtatgatg tcaacatcca gactggttct aacgcctgta atcaacccac   3000

gcatcctaac ggtgactgca gccacttctg cttcccggtg ccaaatttcc agcgagtgtg   3060

tgggtgccct tatggaatga ggctggcttc caatcacttg acatgcgagg gggacccaac   3120

caatgaacca cccacagagc agtgtggctt attttccttc ccctgtaaaa atggcagatg   3180

tgtgcccaat tactatctct gtgatggagt cgatgattgt catgataaca gtgatgagca   3240

actatgtggc acacttaata atacctgttc atcttcggcg ttcacctgtg gccatgggga   3300

gtgcattcct gcacactggc gctgtgacaa acgcaacgac tgtgtggatg gcagtgatga   3360

gcacaactgc cccacccacg cacctgcttc ctgccttgac acccaataca cctgtgataa   3420

tcaccagtgt atctcaaaga actgggtctg tgacacagac aatgattgtg gggatggatc   3480

tgatgaaaag aactgcaatt cgacagagac atgccaacct agtcagttta attgccccaa   3540

tcatcgatgt attgacctat cgtttgtctg tgatggtgac aaggattgtg ttgatggatc   3600

tgatgaggtt ggttgtgtat taaactgtac tgcttctcaa ttcaagtgtg ccagtgggga   3660

taaatgtatt ggcgtcacaa atcgttgtga tggtgttttt gattgcagtg acaactcgga   3720

tgaagcaggc tgtccaacca ggcctcctgg tatgtgccac tcagatgaat ttcagtgcca   3780

agaagatggt atctgcatcc cgaacttctg ggaatgtgat gggcatccag actgcctcta   3840

tggatctgat gagcacaatg cctgtgtccc caagacttgc ccttcatcat atttccactg   3900

tgacaacgga aactgcatcc acagggcatg gctctgtgat cgggacaatg actgcgggga   3960

tatgagtgat gagaaggact gccctactca gccctttcgc tgtcctagtt ggcaatggca   4020

gtgtcttggc cataacatct gtgtgaatct gagtgtagtg tgtgatggca tctttgactg   4080

ccccaatggg acagatgagt ccccactttg caatgggaac agctgctcag atttcaatgg   4140

tggttgtact cacgagtgtg ttcaagagcc ctttggggct aaatgcctat gtccattggg   4200

attcttactt gccaatgatt ctaagacctg tgaagacata gatgaatgtg atattctagg   4260

ctcttgtagc cagcactgtt acaatatgag aggttctttc cggtgctcgt gtgatacagg   4320

ctacatgtta gaaagtgatg ggaggacttg caaagttaca gcatctgaga gtctgctgtt   4380

acttgtggca agtcagaaca aaattattgc cgacagtgtc acctcccagg tccacaatat   4440

ctattcattg gtcgagaatg gttcttacat tgtagctgtt gattttgatt caattagtgg   4500

tcgtatcttt tggtctgatg caactcaggg taaaacctgg agtgcgtttc aaaatggaac   4560

ggacagaaga gtggtatttg acagtagcat catcttgact gaaactattg caatagattg   4620

ggtaggtcgt aatctttact ggacagacta tgctctggaa acaattgaag tctccaaaat   4680

tgatgggagc cacaggactg tgctgattag taaaaaccta acaaatccaa gaggactagc   4740

attagatccc agaatgaatg agcatctact gttctggtct gactggggcc accaccctcg   4800

catcgagcga gccagcatgg acggcagcat gcgcactgtc attgtccagg acaagatctt   4860

ctggccctgc ggcttaacta ttgactaccc caacagactg ctctacttca tggactccta   4920

tcttgattac atggactttt gtgattataa tggacaccat cggagacagg tgatagccag   4980

tgatttgatt atacggcacc cctatgccct aactctcttt gaagactctg tgtactggac   5040

tgaccgtgct actcgtcggg ttatgcgagc caacaagtgg catggaggga accagtcagt   5100

tgtaatgtat aatattcaat ggccccttgg gattgttgcg gttcatcctt cgaaacaacc   5160

aaattccgtg aatccatgtg ccttttcccg ctgcagccat ctctgcctgc tttcctcaca   5220

ggggcctcat ttttactcct gtgtttgtcc ttcaggatgg agtctgtctc ctgatctcct   5280

gaattgcttg agagatgatc aacctttctt aataactgta aggcaacata taatttttgg   5340

aatctccctt aatcctgagg tgaagagcaa tgatgctatg gtccccatag cagggataca   5400

gaatggttta gatgttgaat ttgatgatgc tgagcaatac atctattggg ttgaaaatcc   5460

aggtgaaatt cacagagtga agacagatgg caccaacagg acagtatttg cttctatatc   5520

tatggtgggg ccttctatga acctggcctt agattggatt tcaagaaacc tttattctac   5580

caatcctaga actcagtcaa tcgaggtttt gacactccac ggagatatca gatacagaaa   5640

aacattgatt gccaatgatg ggacagctct tggagttggc tttccaattg gcataactgt   5700

tgatcctgct cgtgggaagc tgtactggtc agaccaagga actgacagtg gggttcctgc   5760

caagatcgcc agtgctaaca tggatggcac atctgtgaaa actctcttta ctgggaacct   5820

cgaacacctg gagtgtgtca ctcttgacat cgaagagcag aaactctact gggcagtcac   5880

tggaagagga gtgattgaaa gaggaaacgt ggatggaaca gatcgaatga tcctggtaca   5940

ccagctttcc cacccctggg gaattgcagt ccatgattct ttcctttatt atactgatga   6000

acagtatgag gtcattgaaa gagttgataa ggccactggg gccaacaaaa tagtcttgag   6060

agataatgtt ccaaatctga ggggtcttca agtttatcac agacgcaatg ccgccgaatc   6120

ctcaaatggc tgtagcaaca acatgaatgc ctgtcagcag atttgcctgc ctgtaccagg   6180

aggattgttt tcctgcgcct gtgccactgg atttaaactc aatcctgata atcggtcctg   6240

ctctccatat aactctttca ttgttgtttc aatgctgtct gcaatcagag gctttagctt   6300

ggaattgtca gatcattcag aaaccatggt gccggtggca ggccaaggac gaaacgcact   6360

gcatgtggat gtggatgtgt cctctggctt tatttattgg tgtgatttta gcagctcagt   6420

ggcatctgat aatgcgatcc gtagaattaa accagatgga tcttctctga tgaacattgt   6480

gacacatgga ataggagaaa atggagtccg gggtattgca gtggattggg tagcaggaaa   6540

tctttatttc accaatgcct ttgtttctga aacactgata gaagttctgc ggatcaatac   6600

tacttaccgc cgtgttcttc ttaaagtcac agtggacatg cctaggcata ttgttgtaga   6660

tcccaagaac agatacctct tctgggctga ctatgggcag agaccaaaga ttgagcgttc   6720

tttccttgac tgtaccaatc gaacagtgct tgtgtcagag ggcattgtca caccacgggg   6780

cttggcagtg gaccgaagtg atggctacgt ttattgggtt gatgattctt tagatataat   6840

tgcaaggatt cgtatcaatg gagagaactc tgaagtgatt cgttatggca gtcgttaccc   6900

aactccttat ggcatcactg tttttgaaaa ttctatcata tgggtagata ggaatttgaa   6960

aaagatcttc caagccagca aggaaccaga gaacacagag ccacccacag tgataagaga   7020

caatatcaac tggctaagag atgtgaccat ctttgacaag caagtccagc cccggtcacc   7080

agcagaggtc aacaacaacc cttgcttgga aaacaatggt gggtgctctc atctctgctt   7140

tgctctgcct ggattgcaca ccccaaaatg tgactgtgcc tttgggaccc tgcaaagtga   7200

tggcaagaat tgtgccattt caacagaaaa tttcctcatc tttgccttgt ctaattcctt   7260

gagaagctta cacttggacc ctgaaaacca tagcccacct ttccaaacaa taaatgtgga   7320

aagaactgtc atgtctctag actatgacag tgtaagtgat agaatctact tcacacaaaa   7380

tttagcctct ggagttggac agatttccta tgccaccctg tcttcaggga tccatactcc   7440

aactgtcatt gcttcaggta tagggactgc tgatggcatt gcctttgact ggattactag   7500

aagaatttat tacagtgact acctcaacca gatgattaat tccatggctg aagatgggtc   7560

taaccgcact gtgatagccc gcgttccaaa accaagagca attgtgttag atccctgcca   7620

agggtacctg tactgggctg actgggatac acatgccaaa atcgagagag ccacattggg   7680

aggaaacttc cgcgtaccca ttgtgaacag cagtctggtc atgcccagtg ggctgactct   7740

ggactatgaa gaggaccttc tctactgggt ggatgctagt ctgcagagga ttgaacgcag   7800

cactctgacg ggcgtggatc gtgaagtcat tgtcaatgca gccgttcatg cttttggctt   7860

gactctctat ggccagtata tttactggac tgacttgtac acacaaagaa tttaccgagc   7920

taacaaatat gacgggtcag gtcagattgc aatgaccaca aatttgctct cccagcccag   7980

gggaatcaac actgttgtga agaaccagaa acaacagtgt aacaatcctt gtgaacagtt   8040

taatgggggc tgcagccata tctgtgcacc aggtccaaat ggtgccgagt gccagtgtcc   8100

acatgagggc aactggtatt tggccaacaa caggaagcac tgcattgtgg acaatggtga   8160

acgatgtggt gcatcttcct tcacctgctc ca                                 8192


<210>  8687
<211>  4000
<212>  PRT
<213>  Homosapiens

<400>  8687

Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His 
            20                  25                  30          


Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp 
        35                  40                  45              


Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val 
    50                  55                  60                  


Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys 
65                  70                  75                  80  


Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly 
                85                  90                  95      


Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln 
            100                 105                 110         


Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp 
        115                 120                 125             


His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr 
    130                 135                 140                 


Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr 
145                 150                 155                 160 


Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu 
                165                 170                 175     


Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn 
            180                 185                 190         


Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys 
        195                 200                 205             


Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly 
    210                 215                 220                 


Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val 
225                 230                 235                 240 


Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys 
                245                 250                 255     


Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser 
            260                 265                 270         


Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly 
        275                 280                 285             


Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly 
    290                 295                 300                 


Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln 
305                 310                 315                 320 


Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr 
                325                 330                 335     


Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys 
            340                 345                 350         


Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg 
        355                 360                 365             


His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr 
    370                 375                 380                 


Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile 
                405                 410                 415     


Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His 
            420                 425                 430         


Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val 
        435                 440                 445             


Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val 
    450                 455                 460                 


Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys 
465                 470                 475                 480 


Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu 
                485                 490                 495     


Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro 
            500                 505                 510         


Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp 
        515                 520                 525             


Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp 
    530                 535                 540                 


Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala 
545                 550                 555                 560 


Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser 
                565                 570                 575     


Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys 
            580                 585                 590         


Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser 
        595                 600                 605             


Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val 
    610                 615                 620                 


Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln 
625                 630                 635                 640 


Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln 
                645                 650                 655     


Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln 
            660                 665                 670         


Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg 
        675                 680                 685             


Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys 
    690                 695                 700                 


Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg 
705                 710                 715                 720 


Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val 
                725                 730                 735     


Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp 
            740                 745                 750         


Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln 
        755                 760                 765             


Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu 
    770                 775                 780                 


Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp 
785                 790                 795                 800 


Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys 
                805                 810                 815     


Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val 
            820                 825                 830         


Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro 
        835                 840                 845             


Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val 
    850                 855                 860                 


Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala 
865                 870                 875                 880 


Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His 
                885                 890                 895     


Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln 
            900                 905                 910         


Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe 
        915                 920                 925             


Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly 
    930                 935                 940                 


Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu 
945                 950                 955                 960 


Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln 
                965                 970                 975     


Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro 
            980                 985                 990         


Asn Phe Gln Arg Val Cys Gly Cys  Pro Tyr Gly Met Arg  Leu Ala Ser 
        995                 1000                 1005             


Asn His  Leu Thr Cys Glu Gly  Asp Pro Thr Asn Glu  Pro Pro Thr 
    1010                 1015                 1020             


Glu Gln  Cys Gly Leu Phe Ser  Phe Pro Cys Lys Asn  Gly Arg Cys 
    1025                 1030                 1035             


Val Pro  Asn Tyr Tyr Leu Cys  Asp Gly Val Asp Asp  Cys His Asp 
    1040                 1045                 1050             


Asn Ser  Asp Glu Gln Leu Cys  Gly Thr Leu Asn Asn  Thr Cys Ser 
    1055                 1060                 1065             


Ser Ser  Ala Phe Thr Cys Gly  His Gly Glu Cys Ile  Pro Ala His 
    1070                 1075                 1080             


Trp Arg  Cys Asp Lys Arg Asn  Asp Cys Val Asp Gly  Ser Asp Glu 
    1085                 1090                 1095             


His Asn  Cys Pro Thr His Ala  Pro Ala Ser Cys Leu  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Thr  Cys Asp Asn His Gln  Cys Ile Ser Lys Asn  Trp Val Cys 
    1115                 1120                 1125             


Asp Thr  Asp Asn Asp Cys Gly  Asp Gly Ser Asp Glu  Lys Asn Cys 
    1130                 1135                 1140             


Asn Ser  Thr Glu Thr Cys Gln  Pro Ser Gln Phe Asn  Cys Pro Asn 
    1145                 1150                 1155             


His Arg  Cys Ile Asp Leu Ser  Phe Val Cys Asp Gly  Asp Lys Asp 
    1160                 1165                 1170             


Cys Val  Asp Gly Ser Asp Glu  Val Gly Cys Val Leu  Asn Cys Thr 
    1175                 1180                 1185             


Ala Ser  Gln Phe Lys Cys Ala  Ser Gly Asp Lys Cys  Ile Gly Val 
    1190                 1195                 1200             


Thr Asn  Arg Cys Asp Gly Val  Phe Asp Cys Ser Asp  Asn Ser Asp 
    1205                 1210                 1215             


Glu Ala  Gly Cys Pro Thr Arg  Pro Pro Gly Met Cys  His Ser Asp 
    1220                 1225                 1230             


Glu Phe  Gln Cys Gln Glu Asp  Gly Ile Cys Ile Pro  Asn Phe Trp 
    1235                 1240                 1245             


Glu Cys  Asp Gly His Pro Asp  Cys Leu Tyr Gly Ser  Asp Glu His 
    1250                 1255                 1260             


Asn Ala  Cys Val Pro Lys Thr  Cys Pro Ser Ser Tyr  Phe His Cys 
    1265                 1270                 1275             


Asp Asn  Gly Asn Cys Ile His  Arg Ala Trp Leu Cys  Asp Arg Asp 
    1280                 1285                 1290             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Lys Asp Cys  Pro Thr Gln 
    1295                 1300                 1305             


Pro Phe  Arg Cys Pro Ser Trp  Gln Trp Gln Cys Leu  Gly His Asn 
    1310                 1315                 1320             


Ile Cys  Val Asn Leu Ser Val  Val Cys Asp Gly Ile  Phe Asp Cys 
    1325                 1330                 1335             


Pro Asn  Gly Thr Asp Glu Ser  Pro Leu Cys Asn Gly  Asn Ser Cys 
    1340                 1345                 1350             


Ser Asp  Phe Asn Gly Gly Cys  Thr His Glu Cys Val  Gln Glu Pro 
    1355                 1360                 1365             


Phe Gly  Ala Lys Cys Leu Cys  Pro Leu Gly Phe Leu  Leu Ala Asn 
    1370                 1375                 1380             


Asp Ser  Lys Thr Cys Glu Asp  Ile Asp Glu Cys Asp  Ile Leu Gly 
    1385                 1390                 1395             


Ser Cys  Ser Gln His Cys Tyr  Asn Met Arg Gly Ser  Phe Arg Cys 
    1400                 1405                 1410             


Ser Cys  Asp Thr Gly Tyr Met  Leu Glu Ser Asp Gly  Arg Thr Cys 
    1415                 1420                 1425             


Lys Val  Thr Ala Ser Glu Ser  Leu Leu Leu Leu Val  Ala Ser Gln 
    1430                 1435                 1440             


Asn Lys  Ile Ile Ala Asp Ser  Val Thr Ser Gln Val  His Asn Ile 
    1445                 1450                 1455             


Tyr Ser  Leu Val Glu Asn Gly  Ser Tyr Ile Val Ala  Val Asp Phe 
    1460                 1465                 1470             


Asp Ser  Ile Ser Gly Arg Ile  Phe Trp Ser Asp Ala  Thr Gln Gly 
    1475                 1480                 1485             


Lys Thr  Trp Ser Ala Phe Gln  Asn Gly Thr Asp Arg  Arg Val Val 
    1490                 1495                 1500             


Phe Asp  Ser Ser Ile Ile Leu  Thr Glu Thr Ile Ala  Ile Asp Trp 
    1505                 1510                 1515             


Val Gly  Arg Asn Leu Tyr Trp  Thr Asp Tyr Ala Leu  Glu Thr Ile 
    1520                 1525                 1530             


Glu Val  Ser Lys Ile Asp Gly  Ser His Arg Thr Val  Leu Ile Ser 
    1535                 1540                 1545             


Lys Asn  Leu Thr Asn Pro Arg  Gly Leu Ala Leu Asp  Pro Arg Met 
    1550                 1555                 1560             


Asn Glu  His Leu Leu Phe Trp  Ser Asp Trp Gly His  His Pro Arg 
    1565                 1570                 1575             


Ile Glu  Arg Ala Ser Met Asp  Gly Ser Met Arg Thr  Val Ile Val 
    1580                 1585                 1590             


Gln Asp  Lys Ile Phe Trp Pro  Cys Gly Leu Thr Ile  Asp Tyr Pro 
    1595                 1600                 1605             


Asn Arg  Leu Leu Tyr Phe Met  Asp Ser Tyr Leu Asp  Tyr Met Asp 
    1610                 1615                 1620             


Phe Cys  Asp Tyr Asn Gly His  His Arg Arg Gln Val  Ile Ala Ser 
    1625                 1630                 1635             


Asp Leu  Ile Ile Arg His Pro  Tyr Ala Leu Thr Leu  Phe Glu Asp 
    1640                 1645                 1650             


Ser Val  Tyr Trp Thr Asp Arg  Ala Thr Arg Arg Val  Met Arg Ala 
    1655                 1660                 1665             


Asn Lys  Trp His Gly Gly Asn  Gln Ser Val Val Met  Tyr Asn Ile 
    1670                 1675                 1680             


Gln Trp  Pro Leu Gly Ile Val  Ala Val His Pro Ser  Lys Gln Pro 
    1685                 1690                 1695             


Asn Ser  Val Asn Pro Cys Ala  Phe Ser Arg Cys Ser  His Leu Cys 
    1700                 1705                 1710             


Leu Leu  Ser Ser Gln Gly Pro  His Phe Tyr Ser Cys  Val Cys Pro 
    1715                 1720                 1725             


Ser Gly  Trp Ser Leu Ser Pro  Asp Leu Leu Asn Cys  Leu Arg Asp 
    1730                 1735                 1740             


Asp Gln  Pro Phe Leu Ile Thr  Val Arg Gln His Ile  Ile Phe Gly 
    1745                 1750                 1755             


Ile Ser  Leu Asn Pro Glu Val  Lys Ser Asn Asp Ala  Met Val Pro 
    1760                 1765                 1770             


Ile Ala  Gly Ile Gln Asn Gly  Leu Asp Val Glu Phe  Asp Asp Ala 
    1775                 1780                 1785             


Glu Gln  Tyr Ile Tyr Trp Val  Glu Asn Pro Gly Glu  Ile His Arg 
    1790                 1795                 1800             


Val Lys  Thr Asp Gly Thr Asn  Arg Thr Val Phe Ala  Ser Ile Ser 
    1805                 1810                 1815             


Met Val  Gly Pro Ser Met Asn  Leu Ala Leu Asp Trp  Ile Ser Arg 
    1820                 1825                 1830             


Asn Leu  Tyr Ser Thr Asn Pro  Arg Thr Gln Ser Ile  Glu Val Leu 
    1835                 1840                 1845             


Thr Leu  His Gly Asp Ile Arg  Tyr Arg Lys Thr Leu  Ile Ala Asn 
    1850                 1855                 1860             


Asp Gly  Thr Ala Leu Gly Val  Gly Phe Pro Ile Gly  Ile Thr Val 
    1865                 1870                 1875             


Asp Pro  Ala Arg Gly Lys Leu  Tyr Trp Ser Asp Gln  Gly Thr Asp 
    1880                 1885                 1890             


Ser Gly  Val Pro Ala Lys Ile  Ala Ser Ala Asn Met  Asp Gly Thr 
    1895                 1900                 1905             


Ser Val  Lys Thr Leu Phe Thr  Gly Asn Leu Glu His  Leu Glu Cys 
    1910                 1915                 1920             


Val Thr  Leu Asp Ile Glu Glu  Gln Lys Leu Tyr Trp  Ala Val Thr 
    1925                 1930                 1935             


Gly Arg  Gly Val Ile Glu Arg  Gly Asn Val Asp Gly  Thr Asp Arg 
    1940                 1945                 1950             


Met Ile  Leu Val His Gln Leu  Ser His Pro Trp Gly  Ile Ala Val 
    1955                 1960                 1965             


His Asp  Ser Phe Leu Tyr Tyr  Thr Asp Glu Gln Tyr  Glu Val Ile 
    1970                 1975                 1980             


Glu Arg  Val Asp Lys Ala Thr  Gly Ala Asn Lys Ile  Val Leu Arg 
    1985                 1990                 1995             


Asp Asn  Val Pro Asn Leu Arg  Gly Leu Gln Val Tyr  His Arg Arg 
    2000                 2005                 2010             


Asn Ala  Ala Glu Ser Ser Asn  Gly Cys Ser Asn Asn  Met Asn Ala 
    2015                 2020                 2025             


Cys Gln  Gln Ile Cys Leu Pro  Val Pro Gly Gly Leu  Phe Ser Cys 
    2030                 2035                 2040             


Ala Cys  Ala Thr Gly Phe Lys  Leu Asn Pro Asp Asn  Arg Ser Cys 
    2045                 2050                 2055             


Ser Pro  Tyr Asn Ser Phe Ile  Val Val Ser Met Leu  Ser Ala Ile 
    2060                 2065                 2070             


Arg Gly  Phe Ser Leu Glu Leu  Ser Asp His Ser Glu  Thr Met Val 
    2075                 2080                 2085             


Pro Val  Ala Gly Gln Gly Arg  Asn Ala Leu His Val  Asp Val Asp 
    2090                 2095                 2100             


Val Ser  Ser Gly Phe Ile Tyr  Trp Cys Asp Phe Ser  Ser Ser Val 
    2105                 2110                 2115             


Ala Ser  Asp Asn Ala Ile Arg  Arg Ile Lys Pro Asp  Gly Ser Ser 
    2120                 2125                 2130             


Leu Met  Asn Ile Val Thr His  Gly Ile Gly Glu Asn  Gly Val Arg 
    2135                 2140                 2145             


Gly Ile  Ala Val Asp Trp Val  Ala Gly Asn Leu Tyr  Phe Thr Asn 
    2150                 2155                 2160             


Ala Phe  Val Ser Glu Thr Leu  Ile Glu Val Leu Arg  Ile Asn Thr 
    2165                 2170                 2175             


Thr Tyr  Arg Arg Val Leu Leu  Lys Val Thr Val Asp  Met Pro Arg 
    2180                 2185                 2190             


His Ile  Val Val Asp Pro Lys  Asn Arg Tyr Leu Phe  Trp Ala Asp 
    2195                 2200                 2205             


Tyr Gly  Gln Arg Pro Lys Ile  Glu Arg Ser Phe Leu  Asp Cys Thr 
    2210                 2215                 2220             


Asn Arg  Thr Val Leu Val Ser  Glu Gly Ile Val Thr  Pro Arg Gly 
    2225                 2230                 2235             


Leu Ala  Val Asp Arg Ser Asp  Gly Tyr Val Tyr Trp  Val Asp Asp 
    2240                 2245                 2250             


Ser Leu  Asp Ile Ile Ala Arg  Ile Arg Ile Asn Gly  Glu Asn Ser 
    2255                 2260                 2265             


Glu Val  Ile Arg Tyr Gly Ser  Arg Tyr Pro Thr Pro  Tyr Gly Ile 
    2270                 2275                 2280             


Thr Val  Phe Glu Asn Ser Ile  Ile Trp Val Asp Arg  Asn Leu Lys 
    2285                 2290                 2295             


Lys Ile  Phe Gln Ala Ser Lys  Glu Pro Glu Asn Thr  Glu Pro Pro 
    2300                 2305                 2310             


Thr Val  Ile Arg Asp Asn Ile  Asn Trp Leu Arg Asp  Val Thr Ile 
    2315                 2320                 2325             


Phe Asp  Lys Gln Val Gln Pro  Arg Ser Pro Ala Glu  Val Asn Asn 
    2330                 2335                 2340             


Asn Pro  Cys Leu Glu Asn Asn  Gly Gly Cys Ser His  Leu Cys Phe 
    2345                 2350                 2355             


Ala Leu  Pro Gly Leu His Thr  Pro Lys Cys Asp Cys  Ala Phe Gly 
    2360                 2365                 2370             


Thr Leu  Gln Ser Asp Gly Lys  Asn Cys Ala Ile Ser  Thr Glu Asn 
    2375                 2380                 2385             


Phe Leu  Ile Phe Ala Leu Ser  Asn Ser Leu Arg Ser  Leu His Leu 
    2390                 2395                 2400             


Asp Pro  Glu Asn His Ser Pro  Pro Phe Gln Thr Ile  Asn Val Glu 
    2405                 2410                 2415             


Arg Thr  Val Met Ser Leu Asp  Tyr Asp Ser Val Ser  Asp Arg Ile 
    2420                 2425                 2430             


Tyr Phe  Thr Gln Asn Leu Ala  Ser Gly Val Gly Gln  Ile Ser Tyr 
    2435                 2440                 2445             


Ala Thr  Leu Ser Ser Gly Ile  His Thr Pro Thr Val  Ile Ala Ser 
    2450                 2455                 2460             


Gly Ile  Gly Thr Ala Asp Gly  Ile Ala Phe Asp Trp  Ile Thr Arg 
    2465                 2470                 2475             


Arg Ile  Tyr Tyr Ser Asp Tyr  Leu Asn Gln Met Ile  Asn Ser Met 
    2480                 2485                 2490             


Ala Glu  Asp Gly Ser Asn Arg  Thr Val Ile Ala Arg  Val Pro Lys 
    2495                 2500                 2505             


Pro Arg  Ala Ile Val Leu Asp  Pro Cys Gln Gly Tyr  Leu Tyr Trp 
    2510                 2515                 2520             


Ala Asp  Trp Asp Thr His Ala  Lys Ile Glu Arg Ala  Thr Leu Gly 
    2525                 2530                 2535             


Gly Asn  Phe Arg Val Pro Ile  Val Asn Ser Ser Leu  Val Met Pro 
    2540                 2545                 2550             


Ser Gly  Leu Thr Leu Asp Tyr  Glu Glu Asp Leu Leu  Tyr Trp Val 
    2555                 2560                 2565             


Asp Ala  Ser Leu Gln Arg Ile  Glu Arg Ser Thr Leu  Thr Gly Val 
    2570                 2575                 2580             


Asp Arg  Glu Val Ile Val Asn  Ala Ala Val His Ala  Phe Gly Leu 
    2585                 2590                 2595             


Thr Leu  Tyr Gly Gln Tyr Ile  Tyr Trp Thr Asp Leu  Tyr Thr Gln 
    2600                 2605                 2610             


Arg Ile  Tyr Arg Ala Asn Lys  Tyr Asp Gly Ser Gly  Gln Ile Ala 
    2615                 2620                 2625             


Met Thr  Thr Asn Leu Leu Ser  Gln Pro Arg Gly Ile  Asn Thr Val 
    2630                 2635                 2640             


Val Lys  Asn Gln Lys Gln Gln  Cys Asn Asn Pro Cys  Glu Gln Phe 
    2645                 2650                 2655             


Asn Gly  Gly Cys Ser His Ile  Cys Ala Pro Gly Pro  Asn Gly Ala 
    2660                 2665                 2670             


Glu Cys  Gln Cys Pro His Glu  Gly Asn Trp Tyr Leu  Ala Asn Asn 
    2675                 2680                 2685             


Arg Lys  His Cys Ile Val Asp  Asn Gly Glu Arg Cys  Gly Ala Ser 
    2690                 2695                 2700             


Ser Phe  Thr Cys Ser Asn Gly  Arg Cys Ile Ser Glu  Glu Trp Lys 
    2705                 2710                 2715             


Cys Asp  Asn Asp Asn Asp Cys  Gly Asp Gly Ser Asp  Glu Met Glu 
    2720                 2725                 2730             


Ser Val  Cys Ala Leu His Thr  Cys Ser Pro Thr Ala  Phe Thr Cys 
    2735                 2740                 2745             


Ala Asn  Gly Arg Cys Val Gln  Tyr Ser Tyr Arg Cys  Asp Tyr Tyr 
    2750                 2755                 2760             


Asn Asp  Cys Gly Asp Gly Ser  Asp Glu Ala Gly Cys  Leu Phe Arg 
    2765                 2770                 2775             


Asp Cys  Asn Ala Thr Thr Glu  Phe Met Cys Asn Asn  Arg Arg Cys 
    2780                 2785                 2790             


Ile Pro  Arg Glu Phe Ile Cys  Asn Gly Val Asp Asn  Cys His Asp 
    2795                 2800                 2805             


Asn Asn  Thr Ser Asp Glu Lys  Asn Cys Pro Asp Arg  Thr Cys Gln 
    2810                 2815                 2820             


Ser Gly  Tyr Thr Lys Cys His  Asn Ser Asn Ile Cys  Ile Pro Arg 
    2825                 2830                 2835             


Val Tyr  Leu Cys Asp Gly Asp  Asn Asp Cys Gly Asp  Asn Ser Asp 
    2840                 2845                 2850             


Glu Asn  Pro Thr Tyr Cys Thr  Thr His Thr Cys Ser  Ser Ser Glu 
    2855                 2860                 2865             


Phe Gln  Cys Ala Ser Gly Arg  Cys Ile Pro Gln His  Trp Tyr Cys 
    2870                 2875                 2880             


Asp Gln  Glu Thr Asp Cys Phe  Asp Ala Ser Asp Glu  Pro Ala Ser 
    2885                 2890                 2895             


Cys Gly  His Ser Glu Arg Thr  Cys Leu Ala Asp Glu  Phe Lys Cys 
    2900                 2905                 2910             


Asp Gly  Gly Arg Cys Ile Pro  Ser Glu Trp Ile Cys  Asp Gly Asp 
    2915                 2920                 2925             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Asp Lys Arg  His Gln Cys 
    2930                 2935                 2940             


Gln Asn  Gln Asn Cys Ser Asp  Ser Glu Phe Leu Cys  Val Asn Asp 
    2945                 2950                 2955             


Arg Pro  Pro Asp Arg Arg Cys  Ile Pro Gln Ser Trp  Val Cys Asp 
    2960                 2965                 2970             


Gly Asp  Val Asp Cys Thr Asp  Gly Tyr Asp Glu Asn  Gln Asn Cys 
    2975                 2980                 2985             


Thr Arg  Arg Thr Cys Ser Glu  Asn Glu Phe Thr Cys  Gly Tyr Gly 
    2990                 2995                 3000             


Leu Cys  Ile Pro Lys Ile Phe  Arg Cys Asp Arg His  Asn Asp Cys 
    3005                 3010                 3015             


Gly Asp  Tyr Ser Asp Glu Arg  Gly Cys Leu Tyr Gln  Thr Cys Gln 
    3020                 3025                 3030             


Gln Asn  Gln Phe Thr Cys Gln  Asn Gly Arg Cys Ile  Ser Lys Thr 
    3035                 3040                 3045             


Phe Val  Cys Asp Glu Asp Asn  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3050                 3055                 3060             


Leu Met  His Leu Cys His Thr  Pro Glu Pro Thr Cys  Pro Pro His 
    3065                 3070                 3075             


Glu Phe  Lys Cys Asp Asn Gly  Arg Cys Ile Glu Met  Met Lys Leu 
    3080                 3085                 3090             


Cys Asn  His Leu Asp Asp Cys  Leu Asp Asn Ser Asp  Glu Lys Gly 
    3095                 3100                 3105             


Cys Gly  Ile Asn Glu Cys His  Asp Pro Ser Ile Ser  Gly Cys Asp 
    3110                 3115                 3120             


His Asn  Cys Thr Asp Thr Leu  Thr Ser Phe Tyr Cys  Ser Cys Arg 
    3125                 3130                 3135             


Pro Gly  Tyr Lys Leu Met Ser  Asp Lys Arg Thr Cys  Val Asp Ile 
    3140                 3145                 3150             


Asp Glu  Cys Thr Glu Met Pro  Phe Val Cys Ser Gln  Lys Cys Glu 
    3155                 3160                 3165             


Asn Val  Ile Gly Ser Tyr Ile  Cys Lys Cys Ala Pro  Gly Tyr Leu 
    3170                 3175                 3180             


Arg Glu  Pro Asp Gly Lys Thr  Cys Arg Gln Asn Ser  Asn Ile Glu 
    3185                 3190                 3195             


Pro Tyr  Leu Ile Phe Ser Asn  Arg Tyr Tyr Leu Arg  Asn Leu Thr 
    3200                 3205                 3210             


Ile Asp  Gly Tyr Phe Tyr Ser  Leu Ile Leu Glu Gly  Leu Asp Asn 
    3215                 3220                 3225             


Val Val  Ala Leu Asp Phe Asp  Arg Val Glu Lys Arg  Leu Tyr Trp 
    3230                 3235                 3240             


Ile Asp  Thr Gln Arg Gln Val  Ile Glu Arg Met Phe  Leu Asn Lys 
    3245                 3250                 3255             


Thr Asn  Lys Glu Thr Ile Ile  Asn His Arg Leu Pro  Ala Ala Glu 
    3260                 3265                 3270             


Ser Leu  Ala Val Asp Trp Val  Ser Arg Lys Leu Tyr  Trp Leu Asp 
    3275                 3280                 3285             


Ala Arg  Leu Asp Gly Leu Phe  Val Ser Asp Leu Asn  Gly Gly His 
    3290                 3295                 3300             


Arg Arg  Met Leu Ala Gln His  Cys Val Asp Ala Asn  Asn Thr Phe 
    3305                 3310                 3315             


Cys Phe  Asp Asn Pro Arg Gly  Leu Ala Leu His Pro  Gln Tyr Gly 
    3320                 3325                 3330             


Tyr Leu  Tyr Trp Ala Asp Trp  Gly His Arg Ala Tyr  Ile Gly Arg 
    3335                 3340                 3345             


Val Gly  Met Asp Gly Thr Asn  Lys Ser Val Ile Ile  Ser Thr Lys 
    3350                 3355                 3360             


Leu Glu  Trp Pro Asn Gly Ile  Thr Ile Asp Tyr Thr  Asn Asp Leu 
    3365                 3370                 3375             


Leu Tyr  Trp Ala Asp Ala His  Leu Gly Tyr Ile Glu  Tyr Ser Asp 
    3380                 3385                 3390             


Leu Glu  Gly His His Arg His  Thr Val Tyr Asp Gly  Ala Leu Pro 
    3395                 3400                 3405             


His Pro  Phe Ala Ile Thr Ile  Phe Glu Asp Thr Ile  Tyr Trp Thr 
    3410                 3415                 3420             


Asp Trp  Asn Thr Arg Thr Val  Glu Lys Gly Asn Lys  Tyr Asp Gly 
    3425                 3430                 3435             


Ser Asn  Arg Gln Thr Leu Val  Asn Thr Thr His Arg  Pro Phe Asp 
    3440                 3445                 3450             


Ile His  Val Tyr His Pro Tyr  Arg Gln Pro Ile Val  Ser Asn Pro 
    3455                 3460                 3465             


Cys Gly  Thr Asn Asn Gly Gly  Cys Ser His Leu Cys  Leu Ile Lys 
    3470                 3475                 3480             


Pro Gly  Gly Lys Gly Phe Thr  Cys Glu Cys Pro Asp  Asp Phe Arg 
    3485                 3490                 3495             


Thr Leu  Gln Leu Ser Gly Ser  Thr Tyr Cys Met Pro  Met Cys Ser 
    3500                 3505                 3510             


Ser Thr  Gln Phe Leu Cys Ala  Asn Asn Glu Lys Cys  Ile Pro Ile 
    3515                 3520                 3525             


Trp Trp  Lys Cys Asp Gly Gln  Lys Asp Cys Ser Asp  Gly Ser Asp 
    3530                 3535                 3540             


Glu Leu  Ala Leu Cys Pro Gln  Arg Phe Cys Arg Leu  Gly Gln Phe 
    3545                 3550                 3555             


Gln Cys  Ser Asp Gly Asn Cys  Thr Ser Pro Gln Thr  Leu Cys Asn 
    3560                 3565                 3570             


Ala His  Gln Asn Cys Pro Asp  Gly Ser Asp Glu Asp  Arg Leu Leu 
    3575                 3580                 3585             


Cys Glu  Asn His His Cys Asp  Ser Asn Glu Trp Gln  Cys Ala Asn 
    3590                 3595                 3600             


Lys Arg  Cys Ile Pro Glu Ser  Trp Gln Cys Asp Thr  Phe Asn Asp 
    3605                 3610                 3615             


Cys Glu  Asp Asn Ser Asp Glu  Asp Ser Ser His Cys  Ala Ser Arg 
    3620                 3625                 3630             


Thr Cys  Arg Pro Gly Gln Phe  Arg Cys Ala Asn Gly  Arg Cys Ile 
    3635                 3640                 3645             


Pro Gln  Ala Trp Lys Cys Asp  Val Asp Asn Asp Cys  Gly Asp His 
    3650                 3655                 3660             


Ser Asp  Glu Pro Ile Glu Glu  Cys Met Ser Ser Ala  His Leu Cys 
    3665                 3670                 3675             


Asp Asn  Phe Thr Glu Phe Ser  Cys Lys Thr Asn Tyr  Arg Cys Ile 
    3680                 3685                 3690             


Pro Lys  Trp Ala Val Cys Asn  Gly Val Asp Asp Cys  Arg Asp Asn 
    3695                 3700                 3705             


Ser Asp  Glu Gln Gly Cys Glu  Glu Arg Thr Cys His  Pro Val Gly 
    3710                 3715                 3720             


Asp Phe  Arg Cys Lys Asn His  His Cys Ile Pro Leu  Arg Trp Gln 
    3725                 3730                 3735             


Cys Asp  Gly Gln Asn Asp Cys  Gly Asp Asn Ser Asp  Glu Glu Asn 
    3740                 3745                 3750             


Cys Ala  Pro Arg Glu Cys Thr  Glu Ser Glu Phe Arg  Cys Val Asn 
    3755                 3760                 3765             


Gln Gln  Cys Ile Pro Ser Arg  Trp Ile Cys Asp His  Tyr Asn Asp 
    3770                 3775                 3780             


Cys Gly  Asp Asn Ser Asp Glu  Arg Asp Cys Glu Met  Arg Thr Cys 
    3785                 3790                 3795             


His Pro  Glu Tyr Phe Gln Cys  Thr Ser Gly His Cys  Val His Ser 
    3800                 3805                 3810             


Glu Leu  Lys Cys Asp Gly Ser  Ala Asp Cys Leu Asp  Ala Ser Asp 
    3815                 3820                 3825             


Glu Ala  Asp Cys Pro Thr Arg  Phe Pro Asp Gly Ala  Tyr Cys Gln 
    3830                 3835                 3840             


Ala Thr  Met Phe Glu Cys Lys  Asn His Val Cys Ile  Pro Pro Tyr 
    3845                 3850                 3855             


Trp Lys  Cys Asp Gly Asp Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3860                 3865                 3870             


Glu Leu  His Leu Cys Leu Asp  Val Pro Cys Asn Ser  Pro Asn Arg 
    3875                 3880                 3885             


Phe Arg  Cys Asp Asn Asn Arg  Cys Ile Tyr Ser His  Glu Val Cys 
    3890                 3895                 3900             


Asn Gly  Val Asp Asp Cys Gly  Asp Gly Thr Asp Glu  Thr Glu Glu 
    3905                 3910                 3915             


His Cys  Arg Lys Pro Thr Pro  Lys Pro Cys Thr Glu  Tyr Glu Tyr 
    3920                 3925                 3930             


Lys Cys  Gly Asn Gly His Cys  Ile Pro His Asp Asn  Val Cys Asp 
    3935                 3940                 3945             


Asp Ala  Asp Asp Cys Gly Asp  Trp Ser Asp Glu Leu  Gly Cys Asn 
    3950                 3955                 3960             


Lys Gly  Lys Glu Arg Thr Cys  Ala Glu Asn Ile Cys  Glu Gln Asn 
    3965                 3970                 3975             


Cys Thr  Gln Leu Asn Glu Gly  Gly Phe Ile Cys Ser  Cys Thr Ala 
    3980                 3985                 3990             


Gly Phe  Glu Thr Asn Val Phe  
    3995                 4000 


<210>  8688
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  8688
gcagacctaa aggagcgttc gctagcagag gcgctgccgg tgcggtgtgc tacgcgcgcc     60

cacctcccgg ggaaggaacg gcgaggccgg ggaccgtcgc ggagatggat cgcgggccgg    120

cagcagtggc gtgcacgctg ctcctggctc tcgtcgcctg cctagcgccg gccagtggcc    180

aagaatgtga cagtgcgcat tttcgctgtg gaagtgggca ttgcatccct gcagactgga    240

ggtgtgatgg gaccaaagac tgttcagatg acgcggatga aattggctgc gctgttgtga    300

cctgccagca gggctatttc aagtgccaga gtgagggaca atgcatcccc aactcctggg    360

tgtgtgacca agatcaagac tgtgatgatg gctcagatga acgtcaagat tgctcacaaa    420

gtacatgctc aagtcatcag ataacatgct ccaatggtca gtgtatccca agtgaataca    480

ggtgcgacca cgtcagagac tgccccgatg gagctgatga gaatgactgc cagtacccaa    540

catgtgagca gcttacttgt gacaatgggg cctgctataa caccagtcag aagtgtgatt    600

ggaaagttga ttgcagggac tcctcagatg aaatcaactg cactgagata tgcttgcaca    660

atgagttttc atgtggcaat ggagagtgta tccctcgtgc ttatgtctgt gaccatgaca    720

atgattgcca agacggcagt gacgaacatg cttgcaacta tccgacctgc ggtggttacc    780

agttcacttg ccccagtggc cgatgcattt atcaaaactg ggtttgtgat ggagaagatg    840

actgtaaaga taatggagat gaagatggat gtgaaagcgg tcctcatgat gttcataaat    900

gttccccaag agaatggtct tgcccagagt cgggacgatg catctccatt tataaagttt    960

gtgatgggat tttagattgc ccaggaagag aagatgaaaa caacactagt accggaaaat   1020

actgtagtat gactctgtgc tctgccttga actgccagta ccagtgccat gagacgccgt   1080

atggaggagc gtgtttttgt cccccaggtt atatcatcaa ccacaatgac agccgtacct   1140

gtgttgagtt tgatgattgc cagatatggg gaatttgtga ccagaagtgt gaaagccgac   1200

ctggccgtca cctgtgccac tgtgaagaag ggtatatctt ggagcgtgga cagtattgca   1260

aagctaatga ttcctttggc gaggcctcca ttatcttctc caatggtcgg gatttgttaa   1320

ttggtgatat tcatggaagg agcttccgga tcctagtgga gtctcagaat cgtggagtgg   1380

ccgtgggtgt ggctttccac tatcacctgc aaagagtttt ttggacagac accgtgcaaa   1440

ataaggtttt ttcagttgac attaatggtt taaatatcca agaggttctc aatgtttctg   1500

ttgaaacccc agagaacctg gctgtggact gggttaataa taaaatctat ctagtggaaa   1560

ccaaggtcaa ccgcatagat atggtaaatt tggatggaag ctatcgggtt acccttataa   1620

ctgaaaactt ggggcatcct agaggaattg ccgtggaccc aactgttggt tatttatttt   1680

tctcagattg ggagagcctt tctggggaac ctaagctgga aagggcattc atggatggca   1740

gcaaccgtaa agacttggtg aaaacaaagc tgggatggcc tgctggggta actctggata   1800

tgatatcgaa gcgtgtttac tgggttgact ctcggtttga ttacattgaa actgtaactt   1860

atgatggaat tcaaaggaag actgtagttc atggaggctc cctcattcct catccctttg   1920

gagtaagctt atttgaaggt caggtgttct ttacagattg gacaaagatg gccgtgctga   1980

aggcaaacaa gttcacagag accaacccac aagtgtacta ccaggcttcc ctgaggccct   2040

atggagtgac tgtttaccat tccctcagac agccctatgc taccaatccg tgtaaagata   2100

acaatggggg ctgtgagcag gtctgtgtcc tcagccacag aacagataat gatggtttgg   2160

gtttccgttg caagtgcaca ttcggcttcc aactggatac agatgagcgc cactgcattg   2220

ctgttcagaa tttcctcatt ttttcatccc aagttgctat tcgtgggatc ccgttcacct   2280

tgtctaccca ggaagatgtc atggttccag tttcggggaa tccttctttc tttgtcggga   2340

ttgattttga cgcccaggac agcactatct ttttttcaga tatgtcaaaa cacatgattt   2400

ttaagcaaaa gattgatggc acaggaagag aaattctcgc agctaacagg gtggaaaatg   2460

ttgaaagttt ggcttttgat tggatttcaa agaatctcta ttggacagac tctcattaca   2520

agagtatcag tgtcatgagg ctagctgata aaacgagacg cacagtagtt cagtatttaa   2580

ataacccacg gtcggtggta gttcatcctt ttgccgggta tctattcttc actgattggt   2640

tccgtcctgc taaaattatg agagcatgga gtgacggatc tcacctcttg cctgtaataa   2700

acactactct tggatggccc aatggcttgg ccatcgattg ggctgcttca cgattgtact   2760

gggtagatgc ctattttgat aaaattgagc acagcacctt tgatggttta gacagaagaa   2820

gactgggcca tatagagcag atgacacatc cgtttggact tgccatcttt ggagagcatt   2880

tattttttac tgactggaga ctgggtgcca ttattcgagt caggaaagca gatggtggag   2940

aaatgacagt tatccgaagt ggcattgctt acatactgca tttgaaatcg tatgatgtca   3000

acatccagac tggttctaac gcctgtaatc aacccacgca tcctaacggt gactgcagcc   3060

acttctgctt cccggtgcca aatttccagc gagtgtgtgg gtgcccttat ggaatgaggc   3120

tggcttccaa tcacttgaca tgcgaggggg acccaaccaa tgaaccaccc acagagcagt   3180

gtggcttatt ttccttcccc tgtaaaaatg gcagatgtgt gcccaattac tatctctgtg   3240

atggagtcga tgattgtcat gataacagtg atgagcaact atgtggcaca cttaataata   3300

cctgttcatc ttcggcgttc acctgtggcc atggggagtg cattcctgca cactggcgct   3360

gtgacaaacg caacgactgt gtggatggca gtgatgagca caactgcccc acccacgcac   3420

ctgcttcctg ccttgacacc caatacacct gtgataatca ccagtgtatc tcaaagaact   3480

gggtctgtga cacagacaat gattgtgggg atggatctga tgaaaagaac tgcaattcga   3540

cagagacatg ccaacctagt cagtttaatt gccccaatca tcgatgtatt gacctatcgt   3600

ttgtctgtga tggtgacaag gattgtgttg atggatctga tgaggttggt tgtgtattaa   3660

actgtactgc ttctcaattc aagtgtgcca gtggggataa atgtattggc gtcacaaatc   3720

gttgtgatgg tgtttttgat tgcagtgaca actcggatga agcaggctgt ccaaccaggc   3780

ctcctggtat gtgccactca gatgaatttc agtgccaaga agatggtatc tgcatcccga   3840

acttctggga atgtgatggg catccagact gcctctatgg atctgatgag cacaatgcct   3900

gtgtccccaa gacttgccct tcatcatatt tccactgtga caacggaaac tgcatccaca   3960

gggcatggct ctgtgatcgg gacaatgact gcggggatat gagtgatgag aaggactgcc   4020

ctactcagcc ctttcgctgt cctagttggc aatggcagtg tcttggccat aacatctgtg   4080

tgaatctgag tgtagtgtgt gatggcatct ttgactgccc caatgggaca gatgagtccc   4140

cactttgcaa tgggaacagc tgctcagatt tcaatggtgg ttgtactcac gagtgtgttc   4200

aagagccctt tggggctaaa tgcctatgtc cattgggatt cttacttgcc aatgattcta   4260

agacctgtga agacatagat gaatgtgata ttctaggctc ttgtagccag cactgttaca   4320

atatgagagg ttctttccgg tgctcgtgtg atacaggcta catgttagaa agtgatggga   4380

ggacttgcaa agttacagca tctgagagtc tgctgttact tgtggcaagt cagaacaaaa   4440

ttattgccga cagtgtcacc tcccaggtcc acaatatcta ttcattggtc gagaatggtt   4500

cttacattgt agctgttgat tttgattcaa ttagtggtcg tatcttttgg tctgatgcaa   4560

ctcagggtaa aacctggagt gcgtttcaaa atggaacgga cagaagagtg gtatttgaca   4620

gtagcatcat cttgactgaa actattgcaa tagattgggt aggtcgtaat ctttactgga   4680

cagactatgc tctggaaaca attgaagtct ccaaaattga tgggagccac aggactgtgc   4740

tgattagtaa aaacctaaca aatccaagag gactagcatt agatcccaga atgaatgagc   4800

atctactgtt ctggtctgac tggggccacc accctcgcat cgagcgagcc agcatggacg   4860

gcagcatgcg cactgtcatt gtccaggaca agatcttctg gccctgcggc ttaactattg   4920

actaccccaa cagactgctc tacttcatgg actcctatct tgattacatg gacttttgtg   4980

attataatgg acaccatcgg agacaggtga tagccagtga tttgattata cggcacccct   5040

atgccctaac tctctttgaa gactctgtgt actggactga ccgtgctact cgtcgggtta   5100

tgcgagccaa caagtggcat ggagggaacc agtcagttgt aatgtataat attcaatggc   5160

cccttgggat tgttgcggtt catccttcga aacaaccaaa ttccgtgaat ccatgtgcct   5220

tttcccgctg cagccatctc tgcctgcttt cctcacaggg gcctcatttt tactcctgtg   5280

tttgtccttc aggatggagt ctgtctcctg atctcctgaa ttgcttgaga gatgatcaac   5340

ctttcttaat aactgtaagg caacatataa tttttggaat ctcccttaat cctgaggtga   5400

agagcaatga tgctatggtc cccatagcag ggatacagaa tggtttagat gttgaatttg   5460

atgatgctga gcaatacatc tattgggttg aaaatccagg tgaaattcac agagtgaaga   5520

cagatggcac caacaggaca gtatttgctt ctatatctat ggtggggcct tctatgaacc   5580

tggccttaga ttggatttca agaaaccttt attctaccaa tcctagaact cagtcaatcg   5640

aggttttgac actccacgga gatatcagat acagaaaaac attgattgcc aatgatggga   5700

cagctcttgg agttggcttt ccaattggca taactgttga tcctgctcgt gggaagctgt   5760

actggtcaga ccaaggaact gacagtgggg ttcctgccaa gatcgccagt gctaacatgg   5820

atggcacatc tgtgaaaact ctctttactg ggaacctcga acacctggag tgtgtcactc   5880

ttgacatcga agagcagaaa ctctactggg cagtcactgg aagaggagtg attgaaagag   5940

gaaacgtgga tggaacagat cgaatgatcc tggtacacca gctttcccac ccctggggaa   6000

ttgcagtcca tgattctttc ctttattata ctgatgaaca gtatgaggtc attgaaagag   6060

ttgataaggc cactggggcc aacaaaatag tcttgagaga taatgttcca aatctgaggg   6120

gtcttcaagt ttatcacaga cgcaatgccg ccgaatcctc aaatggctgt agcaacaaca   6180

tgaatgcctg tcagcagatt tgcctgcctg taccaggagg attgttttcc tgcgcctgtg   6240

ccactggatt taaactcaat cctgataatc ggtcctgctc tccatataac tctttcattg   6300

ttgtttcaat gctgtctgca atcagaggct ttagcttgga attgtcagat cattcagaaa   6360

ccatggtgcc ggtggcaggc caaggacgaa acgcactgca tgtggatgtg gatgtgtcct   6420

ctggctttat ttattggtgt gattttagca gctcagtggc atctgataat gcgatccgta   6480

gaattaaacc agatggatct tctctgatga acattgtgac acatggaata ggagaaaatg   6540

gagtccgggg tattgcagtg gattgggtag caggaaatct ttatttcacc aatgcctttg   6600

tttctgaaac actgatagaa gttctgcgga tcaatactac ttaccgccgt gttcttctta   6660

aagtcacagt ggacatgcct aggcatattg ttgtagatcc caagaacaga tacctcttct   6720

gggctgacta tgggcagaga ccaaagattg agcgttcttt ccttgactgt accaatcgaa   6780

cagtgcttgt gtcagagggc attgtcacac cacggggctt ggcagtggac cgaagtgatg   6840

gctacgttta ttgggttgat gattctttag atataattgc aaggattcgt atcaatggag   6900

agaactctga agtgattcgt tatggcagtc gttacccaac tccttatggc atcactgttt   6960

ttgaaaattc tatcatatgg gtagatagga atttgaaaaa gatcttccaa gccagcaagg   7020

aaccagagaa cacagagcca cccacagtga taagagacaa tatcaactgg ctaagagatg   7080

tgaccatctt tgacaagcaa gtccagcccc ggtcaccagc agaggtcaac aacaaccctt   7140

gcttggaaaa caatggtggg tgctctcatc tctgctttgc tctgcctgga ttgcacaccc   7200

caaaatgtga ctgtgccttt gggaccctgc aaagtgatgg caagaattgt gccatttcaa   7260

cagaaaattt cctcatcttt gccttgtcta attccttgag aagcttacac ttggaccctg   7320

aaaaccatag cccacctttc caaacaataa atgtggaaag aactgtcatg tctctagact   7380

atgacagtgt aagtgataga atctacttca cacaaaattt agcctctgga gttggacaga   7440

tttcctatgc caccctgtct tcagggatcc atactccaac tgtcattgct tcaggtatag   7500

ggactgctga tggcattgcc tttgactgga ttactagaag aatttattac agtgactacc   7560

tcaaccagat gattaattcc atggctgaag atgggtctaa ccgcactgtg atagcccgcg   7620

ttccaaaacc aagagcaatt gtgttagatc cctgccaagg gtacctgtac tgggctgact   7680

gggatacaca tgccaaaatc gagagagcca cattgggagg aaacttccgc gtacccattg   7740

tgaacagcag tctggtcatg cccagtgggc tgactctgga ctatgaagag gaccttctct   7800

actgggtgga tgctagtctg cagaggattg aacgcagcac tctgacgggc gtggatcgtg   7860

aagtcattgt caatgcagcc gttcatgctt ttggcttgac tctctatggc cagtatattt   7920

actggactga cttgtacaca caaagaattt accgagctaa caaatatgac gggtcaggtc   7980

agattgcaat gaccacaaat ttgctctccc agcccagggg aatcaacact gttgtgaaga   8040

accagaaaca acagtgtaac aatccttgtg aacagtttaa tgggggctgc agccatatct   8100

gtgcaccagg tccaaatggt gccgagtgcc agtgtccaca tgagggcaac tggtatttgg   8160

ccaacaacag gaagcactgc attgtggaca at                                 8192


<210>  8689
<211>  4000
<212>  PRT
<213>  Homosapiens

<400>  8689

Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His 
            20                  25                  30          


Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp 
        35                  40                  45              


Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val 
    50                  55                  60                  


Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys 
65                  70                  75                  80  


Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly 
                85                  90                  95      


Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln 
            100                 105                 110         


Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp 
        115                 120                 125             


His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr 
    130                 135                 140                 


Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr 
145                 150                 155                 160 


Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu 
                165                 170                 175     


Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn 
            180                 185                 190         


Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys 
        195                 200                 205             


Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly 
    210                 215                 220                 


Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val 
225                 230                 235                 240 


Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys 
                245                 250                 255     


Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser 
            260                 265                 270         


Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly 
        275                 280                 285             


Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly 
    290                 295                 300                 


Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln 
305                 310                 315                 320 


Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr 
                325                 330                 335     


Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys 
            340                 345                 350         


Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg 
        355                 360                 365             


His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr 
    370                 375                 380                 


Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile 
                405                 410                 415     


Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His 
            420                 425                 430         


Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val 
        435                 440                 445             


Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val 
    450                 455                 460                 


Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys 
465                 470                 475                 480 


Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu 
                485                 490                 495     


Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro 
            500                 505                 510         


Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp 
        515                 520                 525             


Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp 
    530                 535                 540                 


Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala 
545                 550                 555                 560 


Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser 
                565                 570                 575     


Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys 
            580                 585                 590         


Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser 
        595                 600                 605             


Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val 
    610                 615                 620                 


Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln 
625                 630                 635                 640 


Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln 
                645                 650                 655     


Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln 
            660                 665                 670         


Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg 
        675                 680                 685             


Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys 
    690                 695                 700                 


Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg 
705                 710                 715                 720 


Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val 
                725                 730                 735     


Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp 
            740                 745                 750         


Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln 
        755                 760                 765             


Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu 
    770                 775                 780                 


Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp 
785                 790                 795                 800 


Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys 
                805                 810                 815     


Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val 
            820                 825                 830         


Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro 
        835                 840                 845             


Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val 
    850                 855                 860                 


Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala 
865                 870                 875                 880 


Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His 
                885                 890                 895     


Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln 
            900                 905                 910         


Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe 
        915                 920                 925             


Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly 
    930                 935                 940                 


Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu 
945                 950                 955                 960 


Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln 
                965                 970                 975     


Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro 
            980                 985                 990         


Asn Phe Gln Arg Val Cys Gly Cys  Pro Tyr Gly Met Arg  Leu Ala Ser 
        995                 1000                 1005             


Asn His  Leu Thr Cys Glu Gly  Asp Pro Thr Asn Glu  Pro Pro Thr 
    1010                 1015                 1020             


Glu Gln  Cys Gly Leu Phe Ser  Phe Pro Cys Lys Asn  Gly Arg Cys 
    1025                 1030                 1035             


Val Pro  Asn Tyr Tyr Leu Cys  Asp Gly Val Asp Asp  Cys His Asp 
    1040                 1045                 1050             


Asn Ser  Asp Glu Gln Leu Cys  Gly Thr Leu Asn Asn  Thr Cys Ser 
    1055                 1060                 1065             


Ser Ser  Ala Phe Thr Cys Gly  His Gly Glu Cys Ile  Pro Ala His 
    1070                 1075                 1080             


Trp Arg  Cys Asp Lys Arg Asn  Asp Cys Val Asp Gly  Ser Asp Glu 
    1085                 1090                 1095             


His Asn  Cys Pro Thr His Ala  Pro Ala Ser Cys Leu  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Thr  Cys Asp Asn His Gln  Cys Ile Ser Lys Asn  Trp Val Cys 
    1115                 1120                 1125             


Asp Thr  Asp Asn Asp Cys Gly  Asp Gly Ser Asp Glu  Lys Asn Cys 
    1130                 1135                 1140             


Asn Ser  Thr Glu Thr Cys Gln  Pro Ser Gln Phe Asn  Cys Pro Asn 
    1145                 1150                 1155             


His Arg  Cys Ile Asp Leu Ser  Phe Val Cys Asp Gly  Asp Lys Asp 
    1160                 1165                 1170             


Cys Val  Asp Gly Ser Asp Glu  Val Gly Cys Val Leu  Asn Cys Thr 
    1175                 1180                 1185             


Ala Ser  Gln Phe Lys Cys Ala  Ser Gly Asp Lys Cys  Ile Gly Val 
    1190                 1195                 1200             


Thr Asn  Arg Cys Asp Gly Val  Phe Asp Cys Ser Asp  Asn Ser Asp 
    1205                 1210                 1215             


Glu Ala  Gly Cys Pro Thr Arg  Pro Pro Gly Met Cys  His Ser Asp 
    1220                 1225                 1230             


Glu Phe  Gln Cys Gln Glu Asp  Gly Ile Cys Ile Pro  Asn Phe Trp 
    1235                 1240                 1245             


Glu Cys  Asp Gly His Pro Asp  Cys Leu Tyr Gly Ser  Asp Glu His 
    1250                 1255                 1260             


Asn Ala  Cys Val Pro Lys Thr  Cys Pro Ser Ser Tyr  Phe His Cys 
    1265                 1270                 1275             


Asp Asn  Gly Asn Cys Ile His  Arg Ala Trp Leu Cys  Asp Arg Asp 
    1280                 1285                 1290             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Lys Asp Cys  Pro Thr Gln 
    1295                 1300                 1305             


Pro Phe  Arg Cys Pro Ser Trp  Gln Trp Gln Cys Leu  Gly His Asn 
    1310                 1315                 1320             


Ile Cys  Val Asn Leu Ser Val  Val Cys Asp Gly Ile  Phe Asp Cys 
    1325                 1330                 1335             


Pro Asn  Gly Thr Asp Glu Ser  Pro Leu Cys Asn Gly  Asn Ser Cys 
    1340                 1345                 1350             


Ser Asp  Phe Asn Gly Gly Cys  Thr His Glu Cys Val  Gln Glu Pro 
    1355                 1360                 1365             


Phe Gly  Ala Lys Cys Leu Cys  Pro Leu Gly Phe Leu  Leu Ala Asn 
    1370                 1375                 1380             


Asp Ser  Lys Thr Cys Glu Asp  Ile Asp Glu Cys Asp  Ile Leu Gly 
    1385                 1390                 1395             


Ser Cys  Ser Gln His Cys Tyr  Asn Met Arg Gly Ser  Phe Arg Cys 
    1400                 1405                 1410             


Ser Cys  Asp Thr Gly Tyr Met  Leu Glu Ser Asp Gly  Arg Thr Cys 
    1415                 1420                 1425             


Lys Val  Thr Ala Ser Glu Ser  Leu Leu Leu Leu Val  Ala Ser Gln 
    1430                 1435                 1440             


Asn Lys  Ile Ile Ala Asp Ser  Val Thr Ser Gln Val  His Asn Ile 
    1445                 1450                 1455             


Tyr Ser  Leu Val Glu Asn Gly  Ser Tyr Ile Val Ala  Val Asp Phe 
    1460                 1465                 1470             


Asp Ser  Ile Ser Gly Arg Ile  Phe Trp Ser Asp Ala  Thr Gln Gly 
    1475                 1480                 1485             


Lys Thr  Trp Ser Ala Phe Gln  Asn Gly Thr Asp Arg  Arg Val Val 
    1490                 1495                 1500             


Phe Asp  Ser Ser Ile Ile Leu  Thr Glu Thr Ile Ala  Ile Asp Trp 
    1505                 1510                 1515             


Val Gly  Arg Asn Leu Tyr Trp  Thr Asp Tyr Ala Leu  Glu Thr Ile 
    1520                 1525                 1530             


Glu Val  Ser Lys Ile Asp Gly  Ser His Arg Thr Val  Leu Ile Ser 
    1535                 1540                 1545             


Lys Asn  Leu Thr Asn Pro Arg  Gly Leu Ala Leu Asp  Pro Arg Met 
    1550                 1555                 1560             


Asn Glu  His Leu Leu Phe Trp  Ser Asp Trp Gly His  His Pro Arg 
    1565                 1570                 1575             


Ile Glu  Arg Ala Ser Met Asp  Gly Ser Met Arg Thr  Val Ile Val 
    1580                 1585                 1590             


Gln Asp  Lys Ile Phe Trp Pro  Cys Gly Leu Thr Ile  Asp Tyr Pro 
    1595                 1600                 1605             


Asn Arg  Leu Leu Tyr Phe Met  Asp Ser Tyr Leu Asp  Tyr Met Asp 
    1610                 1615                 1620             


Phe Cys  Asp Tyr Asn Gly His  His Arg Arg Gln Val  Ile Ala Ser 
    1625                 1630                 1635             


Asp Leu  Ile Ile Arg His Pro  Tyr Ala Leu Thr Leu  Phe Glu Asp 
    1640                 1645                 1650             


Ser Val  Tyr Trp Thr Asp Arg  Ala Thr Arg Arg Val  Met Arg Ala 
    1655                 1660                 1665             


Asn Lys  Trp His Gly Gly Asn  Gln Ser Val Val Met  Tyr Asn Ile 
    1670                 1675                 1680             


Gln Trp  Pro Leu Gly Ile Val  Ala Val His Pro Ser  Lys Gln Pro 
    1685                 1690                 1695             


Asn Ser  Val Asn Pro Cys Ala  Phe Ser Arg Cys Ser  His Leu Cys 
    1700                 1705                 1710             


Leu Leu  Ser Ser Gln Gly Pro  His Phe Tyr Ser Cys  Val Cys Pro 
    1715                 1720                 1725             


Ser Gly  Trp Ser Leu Ser Pro  Asp Leu Leu Asn Cys  Leu Arg Asp 
    1730                 1735                 1740             


Asp Gln  Pro Phe Leu Ile Thr  Val Arg Gln His Ile  Ile Phe Gly 
    1745                 1750                 1755             


Ile Ser  Leu Asn Pro Glu Val  Lys Ser Asn Asp Ala  Met Val Pro 
    1760                 1765                 1770             


Ile Ala  Gly Ile Gln Asn Gly  Leu Asp Val Glu Phe  Asp Asp Ala 
    1775                 1780                 1785             


Glu Gln  Tyr Ile Tyr Trp Val  Glu Asn Pro Gly Glu  Ile His Arg 
    1790                 1795                 1800             


Val Lys  Thr Asp Gly Thr Asn  Arg Thr Val Phe Ala  Ser Ile Ser 
    1805                 1810                 1815             


Met Val  Gly Pro Ser Met Asn  Leu Ala Leu Asp Trp  Ile Ser Arg 
    1820                 1825                 1830             


Asn Leu  Tyr Ser Thr Asn Pro  Arg Thr Gln Ser Ile  Glu Val Leu 
    1835                 1840                 1845             


Thr Leu  His Gly Asp Ile Arg  Tyr Arg Lys Thr Leu  Ile Ala Asn 
    1850                 1855                 1860             


Asp Gly  Thr Ala Leu Gly Val  Gly Phe Pro Ile Gly  Ile Thr Val 
    1865                 1870                 1875             


Asp Pro  Ala Arg Gly Lys Leu  Tyr Trp Ser Asp Gln  Gly Thr Asp 
    1880                 1885                 1890             


Ser Gly  Val Pro Ala Lys Ile  Ala Ser Ala Asn Met  Asp Gly Thr 
    1895                 1900                 1905             


Ser Val  Lys Thr Leu Phe Thr  Gly Asn Leu Glu His  Leu Glu Cys 
    1910                 1915                 1920             


Val Thr  Leu Asp Ile Glu Glu  Gln Lys Leu Tyr Trp  Ala Val Thr 
    1925                 1930                 1935             


Gly Arg  Gly Val Ile Glu Arg  Gly Asn Val Asp Gly  Thr Asp Arg 
    1940                 1945                 1950             


Met Ile  Leu Val His Gln Leu  Ser His Pro Trp Gly  Ile Ala Val 
    1955                 1960                 1965             


His Asp  Ser Phe Leu Tyr Tyr  Thr Asp Glu Gln Tyr  Glu Val Ile 
    1970                 1975                 1980             


Glu Arg  Val Asp Lys Ala Thr  Gly Ala Asn Lys Ile  Val Leu Arg 
    1985                 1990                 1995             


Asp Asn  Val Pro Asn Leu Arg  Gly Leu Gln Val Tyr  His Arg Arg 
    2000                 2005                 2010             


Asn Ala  Ala Glu Ser Ser Asn  Gly Cys Ser Asn Asn  Met Asn Ala 
    2015                 2020                 2025             


Cys Gln  Gln Ile Cys Leu Pro  Val Pro Gly Gly Leu  Phe Ser Cys 
    2030                 2035                 2040             


Ala Cys  Ala Thr Gly Phe Lys  Leu Asn Pro Asp Asn  Arg Ser Cys 
    2045                 2050                 2055             


Ser Pro  Tyr Asn Ser Phe Ile  Val Val Ser Met Leu  Ser Ala Ile 
    2060                 2065                 2070             


Arg Gly  Phe Ser Leu Glu Leu  Ser Asp His Ser Glu  Thr Met Val 
    2075                 2080                 2085             


Pro Val  Ala Gly Gln Gly Arg  Asn Ala Leu His Val  Asp Val Asp 
    2090                 2095                 2100             


Val Ser  Ser Gly Phe Ile Tyr  Trp Cys Asp Phe Ser  Ser Ser Val 
    2105                 2110                 2115             


Ala Ser  Asp Asn Ala Ile Arg  Arg Ile Lys Pro Asp  Gly Ser Ser 
    2120                 2125                 2130             


Leu Met  Asn Ile Val Thr His  Gly Ile Gly Glu Asn  Gly Val Arg 
    2135                 2140                 2145             


Gly Ile  Ala Val Asp Trp Val  Ala Gly Asn Leu Tyr  Phe Thr Asn 
    2150                 2155                 2160             


Ala Phe  Val Ser Glu Thr Leu  Ile Glu Val Leu Arg  Ile Asn Thr 
    2165                 2170                 2175             


Thr Tyr  Arg Arg Val Leu Leu  Lys Val Thr Val Asp  Met Pro Arg 
    2180                 2185                 2190             


His Ile  Val Val Asp Pro Lys  Asn Arg Tyr Leu Phe  Trp Ala Asp 
    2195                 2200                 2205             


Tyr Gly  Gln Arg Pro Lys Ile  Glu Arg Ser Phe Leu  Asp Cys Thr 
    2210                 2215                 2220             


Asn Arg  Thr Val Leu Val Ser  Glu Gly Ile Val Thr  Pro Arg Gly 
    2225                 2230                 2235             


Leu Ala  Val Asp Arg Ser Asp  Gly Tyr Val Tyr Trp  Val Asp Asp 
    2240                 2245                 2250             


Ser Leu  Asp Ile Ile Ala Arg  Ile Arg Ile Asn Gly  Glu Asn Ser 
    2255                 2260                 2265             


Glu Val  Ile Arg Tyr Gly Ser  Arg Tyr Pro Thr Pro  Tyr Gly Ile 
    2270                 2275                 2280             


Thr Val  Phe Glu Asn Ser Ile  Ile Trp Val Asp Arg  Asn Leu Lys 
    2285                 2290                 2295             


Lys Ile  Phe Gln Ala Ser Lys  Glu Pro Glu Asn Thr  Glu Pro Pro 
    2300                 2305                 2310             


Thr Val  Ile Arg Asp Asn Ile  Asn Trp Leu Arg Asp  Val Thr Ile 
    2315                 2320                 2325             


Phe Asp  Lys Gln Val Gln Pro  Arg Ser Pro Ala Glu  Val Asn Asn 
    2330                 2335                 2340             


Asn Pro  Cys Leu Glu Asn Asn  Gly Gly Cys Ser His  Leu Cys Phe 
    2345                 2350                 2355             


Ala Leu  Pro Gly Leu His Thr  Pro Lys Cys Asp Cys  Ala Phe Gly 
    2360                 2365                 2370             


Thr Leu  Gln Ser Asp Gly Lys  Asn Cys Ala Ile Ser  Thr Glu Asn 
    2375                 2380                 2385             


Phe Leu  Ile Phe Ala Leu Ser  Asn Ser Leu Arg Ser  Leu His Leu 
    2390                 2395                 2400             


Asp Pro  Glu Asn His Ser Pro  Pro Phe Gln Thr Ile  Asn Val Glu 
    2405                 2410                 2415             


Arg Thr  Val Met Ser Leu Asp  Tyr Asp Ser Val Ser  Asp Arg Ile 
    2420                 2425                 2430             


Tyr Phe  Thr Gln Asn Leu Ala  Ser Gly Val Gly Gln  Ile Ser Tyr 
    2435                 2440                 2445             


Ala Thr  Leu Ser Ser Gly Ile  His Thr Pro Thr Val  Ile Ala Ser 
    2450                 2455                 2460             


Gly Ile  Gly Thr Ala Asp Gly  Ile Ala Phe Asp Trp  Ile Thr Arg 
    2465                 2470                 2475             


Arg Ile  Tyr Tyr Ser Asp Tyr  Leu Asn Gln Met Ile  Asn Ser Met 
    2480                 2485                 2490             


Ala Glu  Asp Gly Ser Asn Arg  Thr Val Ile Ala Arg  Val Pro Lys 
    2495                 2500                 2505             


Pro Arg  Ala Ile Val Leu Asp  Pro Cys Gln Gly Tyr  Leu Tyr Trp 
    2510                 2515                 2520             


Ala Asp  Trp Asp Thr His Ala  Lys Ile Glu Arg Ala  Thr Leu Gly 
    2525                 2530                 2535             


Gly Asn  Phe Arg Val Pro Ile  Val Asn Ser Ser Leu  Val Met Pro 
    2540                 2545                 2550             


Ser Gly  Leu Thr Leu Asp Tyr  Glu Glu Asp Leu Leu  Tyr Trp Val 
    2555                 2560                 2565             


Asp Ala  Ser Leu Gln Arg Ile  Glu Arg Ser Thr Leu  Thr Gly Val 
    2570                 2575                 2580             


Asp Arg  Glu Val Ile Val Asn  Ala Ala Val His Ala  Phe Gly Leu 
    2585                 2590                 2595             


Thr Leu  Tyr Gly Gln Tyr Ile  Tyr Trp Thr Asp Leu  Tyr Thr Gln 
    2600                 2605                 2610             


Arg Ile  Tyr Arg Ala Asn Lys  Tyr Asp Gly Ser Gly  Gln Ile Ala 
    2615                 2620                 2625             


Met Thr  Thr Asn Leu Leu Ser  Gln Pro Arg Gly Ile  Asn Thr Val 
    2630                 2635                 2640             


Val Lys  Asn Gln Lys Gln Gln  Cys Asn Asn Pro Cys  Glu Gln Phe 
    2645                 2650                 2655             


Asn Gly  Gly Cys Ser His Ile  Cys Ala Pro Gly Pro  Asn Gly Ala 
    2660                 2665                 2670             


Glu Cys  Gln Cys Pro His Glu  Gly Asn Trp Tyr Leu  Ala Asn Asn 
    2675                 2680                 2685             


Arg Lys  His Cys Ile Val Asp  Asn Gly Glu Arg Cys  Gly Ala Ser 
    2690                 2695                 2700             


Ser Phe  Thr Cys Ser Asn Gly  Arg Cys Ile Ser Glu  Glu Trp Lys 
    2705                 2710                 2715             


Cys Asp  Asn Asp Asn Asp Cys  Gly Asp Gly Ser Asp  Glu Met Glu 
    2720                 2725                 2730             


Ser Val  Cys Ala Leu His Thr  Cys Ser Pro Thr Ala  Phe Thr Cys 
    2735                 2740                 2745             


Ala Asn  Gly Arg Cys Val Gln  Tyr Ser Tyr Arg Cys  Asp Tyr Tyr 
    2750                 2755                 2760             


Asn Asp  Cys Gly Asp Gly Ser  Asp Glu Ala Gly Cys  Leu Phe Arg 
    2765                 2770                 2775             


Asp Cys  Asn Ala Thr Thr Glu  Phe Met Cys Asn Asn  Arg Arg Cys 
    2780                 2785                 2790             


Ile Pro  Arg Glu Phe Ile Cys  Asn Gly Val Asp Asn  Cys His Asp 
    2795                 2800                 2805             


Asn Asn  Thr Ser Asp Glu Lys  Asn Cys Pro Asp Arg  Thr Cys Gln 
    2810                 2815                 2820             


Ser Gly  Tyr Thr Lys Cys His  Asn Ser Asn Ile Cys  Ile Pro Arg 
    2825                 2830                 2835             


Val Tyr  Leu Cys Asp Gly Asp  Asn Asp Cys Gly Asp  Asn Ser Asp 
    2840                 2845                 2850             


Glu Asn  Pro Thr Tyr Cys Thr  Thr His Thr Cys Ser  Ser Ser Glu 
    2855                 2860                 2865             


Phe Gln  Cys Ala Ser Gly Arg  Cys Ile Pro Gln His  Trp Tyr Cys 
    2870                 2875                 2880             


Asp Gln  Glu Thr Asp Cys Phe  Asp Ala Ser Asp Glu  Pro Ala Ser 
    2885                 2890                 2895             


Cys Gly  His Ser Glu Arg Thr  Cys Leu Ala Asp Glu  Phe Lys Cys 
    2900                 2905                 2910             


Asp Gly  Gly Arg Cys Ile Pro  Ser Glu Trp Ile Cys  Asp Gly Asp 
    2915                 2920                 2925             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Asp Lys Arg  His Gln Cys 
    2930                 2935                 2940             


Gln Asn  Gln Asn Cys Ser Asp  Ser Glu Phe Leu Cys  Val Asn Asp 
    2945                 2950                 2955             


Arg Pro  Pro Asp Arg Arg Cys  Ile Pro Gln Ser Trp  Val Cys Asp 
    2960                 2965                 2970             


Gly Asp  Val Asp Cys Thr Asp  Gly Tyr Asp Glu Asn  Gln Asn Cys 
    2975                 2980                 2985             


Thr Arg  Arg Thr Cys Ser Glu  Asn Glu Phe Thr Cys  Gly Tyr Gly 
    2990                 2995                 3000             


Leu Cys  Ile Pro Lys Ile Phe  Arg Cys Asp Arg His  Asn Asp Cys 
    3005                 3010                 3015             


Gly Asp  Tyr Ser Asp Glu Arg  Gly Cys Leu Tyr Gln  Thr Cys Gln 
    3020                 3025                 3030             


Gln Asn  Gln Phe Thr Cys Gln  Asn Gly Arg Cys Ile  Ser Lys Thr 
    3035                 3040                 3045             


Phe Val  Cys Asp Glu Asp Asn  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3050                 3055                 3060             


Leu Met  His Leu Cys His Thr  Pro Glu Pro Thr Cys  Pro Pro His 
    3065                 3070                 3075             


Glu Phe  Lys Cys Asp Asn Gly  Arg Cys Ile Glu Met  Met Lys Leu 
    3080                 3085                 3090             


Cys Asn  His Leu Asp Asp Cys  Leu Asp Asn Ser Asp  Glu Lys Gly 
    3095                 3100                 3105             


Cys Gly  Ile Asn Glu Cys His  Asp Pro Ser Ile Ser  Gly Cys Asp 
    3110                 3115                 3120             


His Asn  Cys Thr Asp Thr Leu  Thr Ser Phe Tyr Cys  Ser Cys Arg 
    3125                 3130                 3135             


Pro Gly  Tyr Lys Leu Met Ser  Asp Lys Arg Thr Cys  Val Asp Ile 
    3140                 3145                 3150             


Asp Glu  Cys Thr Glu Met Pro  Phe Val Cys Ser Gln  Lys Cys Glu 
    3155                 3160                 3165             


Asn Val  Ile Gly Ser Tyr Ile  Cys Lys Cys Ala Pro  Gly Tyr Leu 
    3170                 3175                 3180             


Arg Glu  Pro Asp Gly Lys Thr  Cys Arg Gln Asn Ser  Asn Ile Glu 
    3185                 3190                 3195             


Pro Tyr  Leu Ile Phe Ser Asn  Arg Tyr Tyr Leu Arg  Asn Leu Thr 
    3200                 3205                 3210             


Ile Asp  Gly Tyr Phe Tyr Ser  Leu Ile Leu Glu Gly  Leu Asp Asn 
    3215                 3220                 3225             


Val Val  Ala Leu Asp Phe Asp  Arg Val Glu Lys Arg  Leu Tyr Trp 
    3230                 3235                 3240             


Ile Asp  Thr Gln Arg Gln Val  Ile Glu Arg Met Phe  Leu Asn Lys 
    3245                 3250                 3255             


Thr Asn  Lys Glu Thr Ile Ile  Asn His Arg Leu Pro  Ala Ala Glu 
    3260                 3265                 3270             


Ser Leu  Ala Val Asp Trp Val  Ser Arg Lys Leu Tyr  Trp Leu Asp 
    3275                 3280                 3285             


Ala Arg  Leu Asp Gly Leu Phe  Val Ser Asp Leu Asn  Gly Gly His 
    3290                 3295                 3300             


Arg Arg  Met Leu Ala Gln His  Cys Val Asp Ala Asn  Asn Thr Phe 
    3305                 3310                 3315             


Cys Phe  Asp Asn Pro Arg Gly  Leu Ala Leu His Pro  Gln Tyr Gly 
    3320                 3325                 3330             


Tyr Leu  Tyr Trp Ala Asp Trp  Gly His Arg Ala Tyr  Ile Gly Arg 
    3335                 3340                 3345             


Val Gly  Met Asp Gly Thr Asn  Lys Ser Val Ile Ile  Ser Thr Lys 
    3350                 3355                 3360             


Leu Glu  Trp Pro Asn Gly Ile  Thr Ile Asp Tyr Thr  Asn Asp Leu 
    3365                 3370                 3375             


Leu Tyr  Trp Ala Asp Ala His  Leu Gly Tyr Ile Glu  Tyr Ser Asp 
    3380                 3385                 3390             


Leu Glu  Gly His His Arg His  Thr Val Tyr Asp Gly  Ala Leu Pro 
    3395                 3400                 3405             


His Pro  Phe Ala Ile Thr Ile  Phe Glu Asp Thr Ile  Tyr Trp Thr 
    3410                 3415                 3420             


Asp Trp  Asn Thr Arg Thr Val  Glu Lys Gly Asn Lys  Tyr Asp Gly 
    3425                 3430                 3435             


Ser Asn  Arg Gln Thr Leu Val  Asn Thr Thr His Arg  Pro Phe Asp 
    3440                 3445                 3450             


Ile His  Val Tyr His Pro Tyr  Arg Gln Pro Ile Val  Ser Asn Pro 
    3455                 3460                 3465             


Cys Gly  Thr Asn Asn Gly Gly  Cys Ser His Leu Cys  Leu Ile Lys 
    3470                 3475                 3480             


Pro Gly  Gly Lys Gly Phe Thr  Cys Glu Cys Pro Asp  Asp Phe Arg 
    3485                 3490                 3495             


Thr Leu  Gln Leu Ser Gly Ser  Thr Tyr Cys Met Pro  Met Cys Ser 
    3500                 3505                 3510             


Ser Thr  Gln Phe Leu Cys Ala  Asn Asn Glu Lys Cys  Ile Pro Ile 
    3515                 3520                 3525             


Trp Trp  Lys Cys Asp Gly Gln  Lys Asp Cys Ser Asp  Gly Ser Asp 
    3530                 3535                 3540             


Glu Leu  Ala Leu Cys Pro Gln  Arg Phe Cys Arg Leu  Gly Gln Phe 
    3545                 3550                 3555             


Gln Cys  Ser Asp Gly Asn Cys  Thr Ser Pro Gln Thr  Leu Cys Asn 
    3560                 3565                 3570             


Ala His  Gln Asn Cys Pro Asp  Gly Ser Asp Glu Asp  Arg Leu Leu 
    3575                 3580                 3585             


Cys Glu  Asn His His Cys Asp  Ser Asn Glu Trp Gln  Cys Ala Asn 
    3590                 3595                 3600             


Lys Arg  Cys Ile Pro Glu Ser  Trp Gln Cys Asp Thr  Phe Asn Asp 
    3605                 3610                 3615             


Cys Glu  Asp Asn Ser Asp Glu  Asp Ser Ser His Cys  Ala Ser Arg 
    3620                 3625                 3630             


Thr Cys  Arg Pro Gly Gln Phe  Arg Cys Ala Asn Gly  Arg Cys Ile 
    3635                 3640                 3645             


Pro Gln  Ala Trp Lys Cys Asp  Val Asp Asn Asp Cys  Gly Asp His 
    3650                 3655                 3660             


Ser Asp  Glu Pro Ile Glu Glu  Cys Met Ser Ser Ala  His Leu Cys 
    3665                 3670                 3675             


Asp Asn  Phe Thr Glu Phe Ser  Cys Lys Thr Asn Tyr  Arg Cys Ile 
    3680                 3685                 3690             


Pro Lys  Trp Ala Val Cys Asn  Gly Val Asp Asp Cys  Arg Asp Asn 
    3695                 3700                 3705             


Ser Asp  Glu Gln Gly Cys Glu  Glu Arg Thr Cys His  Pro Val Gly 
    3710                 3715                 3720             


Asp Phe  Arg Cys Lys Asn His  His Cys Ile Pro Leu  Arg Trp Gln 
    3725                 3730                 3735             


Cys Asp  Gly Gln Asn Asp Cys  Gly Asp Asn Ser Asp  Glu Glu Asn 
    3740                 3745                 3750             


Cys Ala  Pro Arg Glu Cys Thr  Glu Ser Glu Phe Arg  Cys Val Asn 
    3755                 3760                 3765             


Gln Gln  Cys Ile Pro Ser Arg  Trp Ile Cys Asp His  Tyr Asn Asp 
    3770                 3775                 3780             


Cys Gly  Asp Asn Ser Asp Glu  Arg Asp Cys Glu Met  Arg Thr Cys 
    3785                 3790                 3795             


His Pro  Glu Tyr Phe Gln Cys  Thr Ser Gly His Cys  Val His Ser 
    3800                 3805                 3810             


Glu Leu  Lys Cys Asp Gly Ser  Ala Asp Cys Leu Asp  Ala Ser Asp 
    3815                 3820                 3825             


Glu Ala  Asp Cys Pro Thr Arg  Phe Pro Asp Gly Ala  Tyr Cys Gln 
    3830                 3835                 3840             


Ala Thr  Met Phe Glu Cys Lys  Asn His Val Cys Ile  Pro Pro Tyr 
    3845                 3850                 3855             


Trp Lys  Cys Asp Gly Asp Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3860                 3865                 3870             


Glu Leu  His Leu Cys Leu Asp  Val Pro Cys Asn Ser  Pro Asn Arg 
    3875                 3880                 3885             


Phe Arg  Cys Asp Asn Asn Arg  Cys Ile Tyr Ser His  Glu Val Cys 
    3890                 3895                 3900             


Asn Gly  Val Asp Asp Cys Gly  Asp Gly Thr Asp Glu  Thr Glu Glu 
    3905                 3910                 3915             


His Cys  Arg Lys Pro Thr Pro  Lys Pro Cys Thr Glu  Tyr Glu Tyr 
    3920                 3925                 3930             


Lys Cys  Gly Asn Gly His Cys  Ile Pro His Asp Asn  Val Cys Asp 
    3935                 3940                 3945             


Asp Ala  Asp Asp Cys Gly Asp  Trp Ser Asp Glu Leu  Gly Cys Asn 
    3950                 3955                 3960             


Lys Gly  Lys Glu Arg Thr Cys  Ala Glu Asn Ile Cys  Glu Gln Asn 
    3965                 3970                 3975             


Cys Thr  Gln Leu Asn Glu Gly  Gly Phe Ile Cys Ser  Cys Thr Ala 
    3980                 3985                 3990             


Gly Phe  Glu Thr Asn Val Phe  
    3995                 4000 


<210>  8690
<211>  4150
<212>  DNA
<213>  Homosapiens

<400>  8690
ctagatcgaa agtcctttgg taatgatgtg tcatacattc tagtcatcaa agacaccatt     60

ttctgggcct gaagtgttct gctggttttt ggaggaatga gaatccaatc tctcataagc    120

cggattcaga aaataggtca tcgatgaaac atctgtatgg attatttcac tataatccta    180

tgatgcttgg acttgaatca cttccagatc ccacagacac ctgggaaatt atagagacca    240

ttggtaaagg cacctatggc aaagtctaca aggtaactaa caagagagat gggagcctgg    300

ctgcagtgaa aattctggat ccagtcagtg atatggatga agaaattgag gcagaataca    360

acattttgca gttccttcct aatcatccca atgttgtaaa gttttatggg atgttttaca    420

aagcggatca ctgtgtaggg ggacagctgt ggctggtcct ggagctgtgt aatgggggct    480

cagtcactga gcttgtcaaa ggtctactca gatgtggcca gcggttggat gaagcaatga    540

tctcatacat cttgtacggg gccctcttgg gccttcagca tttgcacaac aaccgaatca    600

tccaccgtga tgtgaagggg aataacattc ttctgacaac agaaggagga gttaagctcg    660

ttgactttgg tgtttcagct caactcacca gtacacgtct gcggagaaac acatctgttg    720

gcaccccgtt ctggatggcc cctgaggtca ttgcctgtga gcagcagtat gactcttcct    780

atgacgctcg ctgtgacgtc tggtccttgg ggatcacagc tattgaactg ggggatggag    840

accctcccct ctttgacatg catcctgtga aaacactctt taagattcca agaaatcctc    900

cacctacttt acttcatcca gaaaaatggt gtgaagaatt caaccacttt atttcacagt    960

gtcttattaa ggattttgaa aggcgacctt ccgtcacaca tctccttgac cacccattta   1020

ttaaaggagt acatggaaaa gttctgtttc tgcaaaaaca gctggccaag gttctccaag   1080

accagaagca tcaaaatcct gttgctaaaa ccaggcatga gaggatgcat accagaagac   1140

cttatcatgt ggaagatgct gaaaaatact gccttgagga tgatttggtc aacctagagg   1200

ttctggatga ggatacaatt atccatcagt tgcagaaacg ttatgcagac ttgctaattt   1260

acacatatgt tggagacatc ttaattgcct taaacccctt ccagaatcta agcatatact   1320

ctccacagtt ttccagactt tatcatgggg tgaaacgcgc ctccaatccc ccccacatat   1380

ttgcatcagc agatgctgct taccagtgca tggttactct cagcaaagac cagtgcattg   1440

tcatcagcgg agagagtggc tctgggaaga cagaaagcgc ccacctgatt gttcagcatt   1500

tgactttctt gggaaaggcc aataatcaga ccttgagaga gaaaattcta caagtcaact   1560

ccctggtgga agcctttggg aactcatgca ctgccatcaa tgacaactcg agccgttttg   1620

gaaaatatct ggaaatgatg tttacaccaa ctggagttgt gatgggggca agaatctctg   1680

aatatctcct ggaaaaatcc agagttataa aacaggcagc gagagagaaa aattttcata   1740

tattttacta tatttatgct ggtcttcatc accaaaagaa gctttctgat ttcagacttc   1800

ctgaggaaaa acctcctagg tacatagctg atgaaactgg aagggtgatg cacgacataa   1860

cttccaagga gtcttacaga agacaattcg aagcaattca gcattgcttc aggattatag   1920

ggttcacgga caaagaggtg cactcagtgt acagaatttt ggctgggatt ttgaatattg   1980

ggaacattga gttcgcagct atttcctctc aacatcagac tgataaaagt gaggtgccca   2040

atgctgaagc tttgcaaaat gctgcctctg ttctgtgcat tagccctgaa gagctccagg   2100

aggccctcac ctcccactgt gtggtcaccc ggggcgagac catcatccgt gccaacactg   2160

tagacagggc tgcggacgtt cgagacgcca tgtccaaagc cctgtatggg aggctcttca   2220

gctggattgt gaatcgcatt aatacactcc tgcagccaga cgaaaacata tgtagtgcag   2280

gaggtggaat gaatgtgggg atcttggata tctttggatt cgagaatttt cagagaaatt   2340

catttgagca gctctgcata aacatcgcca atgagcaaat ccagtactat ttcaatcagc   2400

atgtttttgc tcttgagcag atggaatatc agaatgaagg cattgatgct gtacccgtgg   2460

aatatgagga caaccgcccg ctcttggaca tgttcctcca gaaacccctg ggactgcttg   2520

cacttttgga tgaggaaagt cggtttcccc aagcaactga ccagaccctg gttgataaat   2580

ttgaagataa tctacgatgc aaatacttct ggaggcccaa aggagtggaa ctgtgctttg   2640

gcattcagca ttatgctgga aaggtattat atgatgcttc tggggttctt gagaaaaata   2700

gagacactct ccctgccgat gtggttgtgg tcctgagaac gtcagaaaac aagcttcttc   2760

agcagctctt ctcaatccct ctgaccaaaa caggtaattt ggcccagaca agagctagga   2820

taacagtggc ctcaagttct ttgcctccac atttcagtgc tgggaaagcc aaggtggaca   2880

ctctggaggt gatacggcat ccggaagaaa ccaccaacat gaagaggcaa actgtggctt   2940

cttacttccg gtattctctg atggacctgc tctccaaaat ggtggttgga cagccccact   3000

ttgtgcgctg cattaaaccc aatgatgacc gagaggccct gcagttctct cgagagaggg   3060

tgctggccca gctccgctcc acagggattc tggagacagt cagcatccgc cgccagggct   3120

attcccaccg catccttttt gaagaatttg tgaaaaggta ttattacttg gcattcacag   3180

cacatcaaac acctcttgct agcaaagaga gctgtgtggc tatcttggaa aagtccagat   3240

tagatcactg ggtactggga aaaacaaagg tttttctcaa atattaccat gttgagcaat   3300

taaatttgct gcttcgagaa gtcataggca gagtggttgt gctgcaggca tataccaagg   3360

ggtggcttgg agccaggaga tacaaaaggg tcagagagaa gagagagaag ggagccattg   3420

ccatccagtc agcctggaga ggatatgatg ctcggaggaa atttaagaaa ataagcaaca   3480

gaaggaatga gtctgctgct cataatcaag caggggacac ttcaaaccaa agcagtgggc   3540

cacattcccc cgtcgcagca ggtacgaggg gaagtgccga ggttcaagac tgcagcgagc   3600

ctggtgacca taaagttctc aggggctctg tacatcgtag gagccattca caagcagaat   3660

ccaacaatgg ccgtacacag acttcaagca actctcctgc tgtcacagag aaaaatgggt   3720

gagcattatc tgctaagagt tccctgttgt aaactcaggt gctccattct aatggataat   3780

gaaatggtaa tggataatgc aacaagtatt tctaccacta tggtattttg gtgaactgga   3840

gagagtggaa ccaaaaagcg tttccagggc tgggcgtggt ggctcatgcc tgtaatccca   3900

gcactttgtg ggggccgagg tgggtggatc acctgaggtc aggagtttga gactagcctg   3960

gcccacatgg caaaaccccg cctctactaa aaatacaaaa atgagctggc catggtggca   4020

tgtgcctgta atcccagcta ctcaggaggc tgaggcagga gaatcacttg aaccatggag   4080

gtggaggttg cagtgagcca agattgtgcc actgcacttc agcctgggca acacagcaag   4140

actctgtctc                                                          4150


<210>  8691
<211>  1192
<212>  PRT
<213>  Homosapiens

<400>  8691

Met Lys His Leu Tyr Gly Leu Phe His Tyr Asn Pro Met Met Leu Gly 
1               5                   10                  15      


Leu Glu Ser Leu Pro Asp Pro Thr Asp Thr Trp Glu Ile Ile Glu Thr 
            20                  25                  30          


Ile Gly Lys Gly Thr Tyr Gly Lys Val Tyr Lys Val Thr Asn Lys Arg 
        35                  40                  45              


Asp Gly Ser Leu Ala Ala Val Lys Ile Leu Asp Pro Val Ser Asp Met 
    50                  55                  60                  


Asp Glu Glu Ile Glu Ala Glu Tyr Asn Ile Leu Gln Phe Leu Pro Asn 
65                  70                  75                  80  


His Pro Asn Val Val Lys Phe Tyr Gly Met Phe Tyr Lys Ala Asp His 
                85                  90                  95      


Cys Val Gly Gly Gln Leu Trp Leu Val Leu Glu Leu Cys Asn Gly Gly 
            100                 105                 110         


Ser Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys Gly Gln Arg Leu 
        115                 120                 125             


Asp Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala Leu Leu Gly Leu 
    130                 135                 140                 


Gln His Leu His Asn Asn Arg Ile Ile His Arg Asp Val Lys Gly Asn 
145                 150                 155                 160 


Asn Ile Leu Leu Thr Thr Glu Gly Gly Val Lys Leu Val Asp Phe Gly 
                165                 170                 175     


Val Ser Ala Gln Leu Thr Ser Thr Arg Leu Arg Arg Asn Thr Ser Val 
            180                 185                 190         


Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Ala Cys Glu Gln Gln 
        195                 200                 205             


Tyr Asp Ser Ser Tyr Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile 
    210                 215                 220                 


Thr Ala Ile Glu Leu Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His 
225                 230                 235                 240 


Pro Val Lys Thr Leu Phe Lys Ile Pro Arg Asn Pro Pro Pro Thr Leu 
                245                 250                 255     


Leu His Pro Glu Lys Trp Cys Glu Glu Phe Asn His Phe Ile Ser Gln 
            260                 265                 270         


Cys Leu Ile Lys Asp Phe Glu Arg Arg Pro Ser Val Thr His Leu Leu 
        275                 280                 285             


Asp His Pro Phe Ile Lys Gly Val His Gly Lys Val Leu Phe Leu Gln 
    290                 295                 300                 


Lys Gln Leu Ala Lys Val Leu Gln Asp Gln Lys His Gln Asn Pro Val 
305                 310                 315                 320 


Ala Lys Thr Arg His Glu Arg Met His Thr Arg Arg Pro Tyr His Val 
                325                 330                 335     


Glu Asp Ala Glu Lys Tyr Cys Leu Glu Asp Asp Leu Val Asn Leu Glu 
            340                 345                 350         


Val Leu Asp Glu Asp Thr Ile Ile His Gln Leu Gln Lys Arg Tyr Ala 
        355                 360                 365             


Asp Leu Leu Ile Tyr Thr Tyr Val Gly Asp Ile Leu Ile Ala Leu Asn 
    370                 375                 380                 


Pro Phe Gln Asn Leu Ser Ile Tyr Ser Pro Gln Phe Ser Arg Leu Tyr 
385                 390                 395                 400 


His Gly Val Lys Arg Ala Ser Asn Pro Pro His Ile Phe Ala Ser Ala 
                405                 410                 415     


Asp Ala Ala Tyr Gln Cys Met Val Thr Leu Ser Lys Asp Gln Cys Ile 
            420                 425                 430         


Val Ile Ser Gly Glu Ser Gly Ser Gly Lys Thr Glu Ser Ala His Leu 
        435                 440                 445             


Ile Val Gln His Leu Thr Phe Leu Gly Lys Ala Asn Asn Gln Thr Leu 
    450                 455                 460                 


Arg Glu Lys Ile Leu Gln Val Asn Ser Leu Val Glu Ala Phe Gly Asn 
465                 470                 475                 480 


Ser Cys Thr Ala Ile Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Leu 
                485                 490                 495     


Glu Met Met Phe Thr Pro Thr Gly Val Val Met Gly Ala Arg Ile Ser 
            500                 505                 510         


Glu Tyr Leu Leu Glu Lys Ser Arg Val Ile Lys Gln Ala Ala Arg Glu 
        515                 520                 525             


Lys Asn Phe His Ile Phe Tyr Tyr Ile Tyr Ala Gly Leu His His Gln 
    530                 535                 540                 


Lys Lys Leu Ser Asp Phe Arg Leu Pro Glu Glu Lys Pro Pro Arg Tyr 
545                 550                 555                 560 


Ile Ala Asp Glu Thr Gly Arg Val Met His Asp Ile Thr Ser Lys Glu 
                565                 570                 575     


Ser Tyr Arg Arg Gln Phe Glu Ala Ile Gln His Cys Phe Arg Ile Ile 
            580                 585                 590         


Gly Phe Thr Asp Lys Glu Val His Ser Val Tyr Arg Ile Leu Ala Gly 
        595                 600                 605             


Ile Leu Asn Ile Gly Asn Ile Glu Phe Ala Ala Ile Ser Ser Gln His 
    610                 615                 620                 


Gln Thr Asp Lys Ser Glu Val Pro Asn Ala Glu Ala Leu Gln Asn Ala 
625                 630                 635                 640 


Ala Ser Val Leu Cys Ile Ser Pro Glu Glu Leu Gln Glu Ala Leu Thr 
                645                 650                 655     


Ser His Cys Val Val Thr Arg Gly Glu Thr Ile Ile Arg Ala Asn Thr 
            660                 665                 670         


Val Asp Arg Ala Ala Asp Val Arg Asp Ala Met Ser Lys Ala Leu Tyr 
        675                 680                 685             


Gly Arg Leu Phe Ser Trp Ile Val Asn Arg Ile Asn Thr Leu Leu Gln 
    690                 695                 700                 


Pro Asp Glu Asn Ile Cys Ser Ala Gly Gly Gly Met Asn Val Gly Ile 
705                 710                 715                 720 


Leu Asp Ile Phe Gly Phe Glu Asn Phe Gln Arg Asn Ser Phe Glu Gln 
                725                 730                 735     


Leu Cys Ile Asn Ile Ala Asn Glu Gln Ile Gln Tyr Tyr Phe Asn Gln 
            740                 745                 750         


His Val Phe Ala Leu Glu Gln Met Glu Tyr Gln Asn Glu Gly Ile Asp 
        755                 760                 765             


Ala Val Pro Val Glu Tyr Glu Asp Asn Arg Pro Leu Leu Asp Met Phe 
    770                 775                 780                 


Leu Gln Lys Pro Leu Gly Leu Leu Ala Leu Leu Asp Glu Glu Ser Arg 
785                 790                 795                 800 


Phe Pro Gln Ala Thr Asp Gln Thr Leu Val Asp Lys Phe Glu Asp Asn 
                805                 810                 815     


Leu Arg Cys Lys Tyr Phe Trp Arg Pro Lys Gly Val Glu Leu Cys Phe 
            820                 825                 830         


Gly Ile Gln His Tyr Ala Gly Lys Val Leu Tyr Asp Ala Ser Gly Val 
        835                 840                 845             


Leu Glu Lys Asn Arg Asp Thr Leu Pro Ala Asp Val Val Val Val Leu 
    850                 855                 860                 


Arg Thr Ser Glu Asn Lys Leu Leu Gln Gln Leu Phe Ser Ile Pro Leu 
865                 870                 875                 880 


Thr Lys Thr Gly Asn Leu Ala Gln Thr Arg Ala Arg Ile Thr Val Ala 
                885                 890                 895     


Ser Ser Ser Leu Pro Pro His Phe Ser Ala Gly Lys Ala Lys Val Asp 
            900                 905                 910         


Thr Leu Glu Val Ile Arg His Pro Glu Glu Thr Thr Asn Met Lys Arg 
        915                 920                 925             


Gln Thr Val Ala Ser Tyr Phe Arg Tyr Ser Leu Met Asp Leu Leu Ser 
    930                 935                 940                 


Lys Met Val Val Gly Gln Pro His Phe Val Arg Cys Ile Lys Pro Asn 
945                 950                 955                 960 


Asp Asp Arg Glu Ala Leu Gln Phe Ser Arg Glu Arg Val Leu Ala Gln 
                965                 970                 975     


Leu Arg Ser Thr Gly Ile Leu Glu Thr Val Ser Ile Arg Arg Gln Gly 
            980                 985                 990         


Tyr Ser His Arg Ile Leu Phe Glu  Glu Phe Val Lys Arg  Tyr Tyr Tyr 
        995                 1000                 1005             


Leu Ala  Phe Thr Ala His Gln  Thr Pro Leu Ala Ser  Lys Glu Ser 
    1010                 1015                 1020             


Cys Val  Ala Ile Leu Glu Lys  Ser Arg Leu Asp His  Trp Val Leu 
    1025                 1030                 1035             


Gly Lys  Thr Lys Val Phe Leu  Lys Tyr Tyr His Val  Glu Gln Leu 
    1040                 1045                 1050             


Asn Leu  Leu Leu Arg Glu Val  Ile Gly Arg Val Val  Val Leu Gln 
    1055                 1060                 1065             


Ala Tyr  Thr Lys Gly Trp Leu  Gly Ala Arg Arg Tyr  Lys Arg Val 
    1070                 1075                 1080             


Arg Glu  Lys Arg Glu Lys Gly  Ala Ile Ala Ile Gln  Ser Ala Trp 
    1085                 1090                 1095             


Arg Gly  Tyr Asp Ala Arg Arg  Lys Phe Lys Lys Ile  Ser Asn Arg 
    1100                 1105                 1110             


Arg Asn  Glu Ser Ala Ala His  Asn Gln Ala Gly Asp  Thr Ser Asn 
    1115                 1120                 1125             


Gln Ser  Ser Gly Pro His Ser  Pro Val Ala Ala Gly  Thr Arg Gly 
    1130                 1135                 1140             


Ser Ala  Glu Val Gln Asp Cys  Ser Glu Pro Gly Asp  His Lys Val 
    1145                 1150                 1155             


Leu Arg  Gly Ser Val His Arg  Arg Ser His Ser Gln  Ala Glu Ser 
    1160                 1165                 1170             


Asn Asn  Gly Arg Thr Gln Thr  Ser Ser Asn Ser Pro  Ala Val Thr 
    1175                 1180                 1185             


Glu Lys  Asn Gly 
    1190         


<210>  8692
<211>  4000
<212>  DNA
<213>  Homosapiens

<400>  8692
ctagatcgaa agtcctttgg taatgatgtg tcatacattc tagtcatcaa agacaccatt     60

ttctgggcct gaagtgttct gctggttttt ggaggaatga gaatccaatc tctcataagc    120

cggattcaga aaataggtca tcgatgaaac atctgtatgg attatttcac tataatccta    180

tgatgcttgg acttgaatca cttccagatc ccacagacac ctgggaaatt atagagacca    240

ttggtaaagg cacctatggc aaagtctaca aggtaactaa caagagagat gggagcctgg    300

ctgcagtgaa aattctggat ccagtcagtg atatggatga agaaattgag gcagaataca    360

acattttgca gttccttcct aatcatccca atgttgtaaa gttttatggg atgttttaca    420

aagcggatca ctgtgtaggg ggacagctgt ggctggtcct ggagctgtgt aatgggggct    480

cagtcactga gcttgtcaaa ggtctactca gatgtggcca gcggttggat gaagcaatga    540

tctcatacat cttgtacggg gccctcttgg gccttcagca tttgcacaac aaccgaatca    600

tccaccgtga tgtgaagggg aataacattc ttctgacaac agaaggagga gttaagctcg    660

ttgactttgg tgtttcagct caactcacca gtacacgtct gcggagaaac acatctgttg    720

gcaccccgtt ctggatggcc cctgaggtca ttgcctgtga gcagcagtat gactcttcct    780

atgacgctcg ctgtgacgtc tggtccttgg ggatcacagc tattgaactg ggggatggag    840

accctcccct ctttgacatg catcctgtga aaacactctt taagattcca agaaatcctc    900

cacctacttt acttcatcca gaaaaatggt gtgaagaatt caaccacttt atttcacagt    960

gtcttattaa ggattttgaa aggcgacctt ccgtcacaca tctccttgac cacccattta   1020

ttaaaggagt acatggaaaa gttctgtttc tgcaaaaaca gctggccaag gttctccaag   1080

accagaagca tcaaaatcct gttgctaaaa ccaggcatga gaggatgcat accagaagac   1140

cttatcatgt ggaagatgct gaaaaatact gccttgagga tgatttggtc aacctagagg   1200

ttctggatga ggatacaatt atccatcagt tgcagaaacg ttatgcagac ttgctaattt   1260

acacatatgt tggagacatc ttaattgcct taaacccctt ccagaatcta agcatatact   1320

ctccacagtt ttccagactt tatcatgggg tgaaacgcgc ctccaatccc ccccacatat   1380

ttgcatcagc agatgctgct taccagtgca tggttactct cagcaaagac cagtgcattg   1440

tcatcagcgg agagagtggc tctgggaaga cagaaagcgc ccacctgatt gttcagcatt   1500

tgactttctt gggaaaggcc aataatcaga ccttgagaga gaaaattcta caagtcaact   1560

ccctggtgga agcctttggg aactcatgca ctgccatcaa tgacaactcg agccgttttg   1620

gaaaatatct ggaaatgatg tttacaccaa ctggagttgt gatgggggca agaatctctg   1680

aatatctcct ggaaaaatcc agagttataa aacaggcagc gagagagaaa aattttcata   1740

tattttacta tatttatgct ggtcttcatc accaaaagaa gctttctgat ttcagacttc   1800

ctgaggaaaa acctcctagg tacatagctg atgaaactgg aagggtgatg cacgacataa   1860

cttccaagga gtcttacaga agacaattcg aagcaattca gcattgcttc aggattatag   1920

ggttcacgga caaagaggtg cactcagtgt acagaatttt ggctgggatt ttgaatattg   1980

ggaacattga gttcgcagct atttcctctc aacatcagac tgataaaagt gaggtgccca   2040

atgctgaagc tttgcaaaat gctgcctctg ttctgtgcat tagccctgaa gagctccagg   2100

aggccctcac ctcccactgt gtggtcaccc ggggcgagac catcatccgt gccaacactg   2160

tagacagggc tgcggacgtt cgagacgcca tgtccaaagc cctgtatggg aggctcttca   2220

gctggattgt gaatcgcatt aatacactcc tgcagccaga cgaaaacata tgtagtgcag   2280

gaggtggaat gaatgtgggg atcttggata tctttggatt cgagaatttt cagagaaatt   2340

catttgagca gctctgcata aacatcgcca atgagcaaat ccagtactat ttcaatcagc   2400

atgtttttgc tcttgagcag atggaatatc agaatgaagg cattgatgct gtacccgtgg   2460

aatatgagga caaccgcccg ctcttggaca tgttcctcca gaaacccctg ggactgcttg   2520

cacttttgga tgaggaaagt cggtttcccc aagcaactga ccagaccctg gttgataaat   2580

ttgaagataa tctacgatgc aaatacttct ggaggcccaa aggagtggaa ctgtgctttg   2640

gcattcagca ttatgctgga aaggtattat atgatgcttc tggggttctt gagaaaaata   2700

gagacactct ccctgccgat gtggttgtgg tcctgagaac gtcagaaaac aagcttcttc   2760

agcagctctt ctcaatccct ctgaccaaaa caggtaattt ggcccagaca agagctagga   2820

taacagtggc ctcaagttct ttgcctccac atttcagtgc tgggaaagcc aaggtggaca   2880

ctctggaggt gatacggcat ccggaagaaa ccaccaacat gaagaggcaa actgtggctt   2940

cttacttccg gtattctctg atggacctgc tctccaaaat ggtggttgga cagccccact   3000

ttgtgcgctg cattaaaccc aatgatgacc gagaggccct gcagttctct cgagagaggg   3060

tgctggccca gctccgctcc acagggattc tggagacagt cagcatccgc cgccagggct   3120

attcccaccg catccttttt gaagaatttg tgaaaaggta ttattacttg gcattcacag   3180

cacatcaaac acctcttgct agcaaagaga gctgtgtggc tatcttggaa aagtccagat   3240

tagatcactg ggtactggga aaaacaaagg tttttctcaa atattaccat gttgagcaat   3300

taaatttgct gcttcgagaa gtcataggca gagtggttgt gctgcaggca tataccaagg   3360

ggtggcttgg agccaggaga tacaaaaggg tcagagagaa gagagagaag ggagccattg   3420

ccatccagtc agcctggaga ggatatgatg ctcggaggaa atttaagaaa ataagcaaca   3480

gaaggaatga gtctgctgct cataatcaag caggggacac ttcaaaccaa agcagtgggc   3540

cacattcccc cgtcgcagca ggtacgaggg gaagtgccga ggttcaagac tgcagcgagc   3600

ctggtgacca taaagttctc aggggctctg tacatcgtag gagccattca caagcagaat   3660

ccaacaatgg ccgtacacag acttcaagca actctcctgc tgtcacagag aaaaatggat   3720

ggagtttcac tctgttgctc aggctggagt gcaatagcat gatctcagct gactgcaacc   3780

tccgccctct gggttcaagt gattctcctg cctcagcctc ccgagtagct gggattacag   3840

gcattcacaa gcccagagtt ctccaaaagg gtgcgatatc ttcgcaggac atgcaaacaa   3900

gcactcggtt tctgggactg atttgctgtc ttctcggata tgccatcctg ctccagatca   3960

gcaaggattg agtctctggg gagcccctca aaagcctggt                         4000


<210>  8693
<211>  1275
<212>  PRT
<213>  Homosapiens

<400>  8693

Met Lys His Leu Tyr Gly Leu Phe His Tyr Asn Pro Met Met Leu Gly 
1               5                   10                  15      


Leu Glu Ser Leu Pro Asp Pro Thr Asp Thr Trp Glu Ile Ile Glu Thr 
            20                  25                  30          


Ile Gly Lys Gly Thr Tyr Gly Lys Val Tyr Lys Val Thr Asn Lys Arg 
        35                  40                  45              


Asp Gly Ser Leu Ala Ala Val Lys Ile Leu Asp Pro Val Ser Asp Met 
    50                  55                  60                  


Asp Glu Glu Ile Glu Ala Glu Tyr Asn Ile Leu Gln Phe Leu Pro Asn 
65                  70                  75                  80  


His Pro Asn Val Val Lys Phe Tyr Gly Met Phe Tyr Lys Ala Asp His 
                85                  90                  95      


Cys Val Gly Gly Gln Leu Trp Leu Val Leu Glu Leu Cys Asn Gly Gly 
            100                 105                 110         


Ser Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys Gly Gln Arg Leu 
        115                 120                 125             


Asp Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala Leu Leu Gly Leu 
    130                 135                 140                 


Gln His Leu His Asn Asn Arg Ile Ile His Arg Asp Val Lys Gly Asn 
145                 150                 155                 160 


Asn Ile Leu Leu Thr Thr Glu Gly Gly Val Lys Leu Val Asp Phe Gly 
                165                 170                 175     


Val Ser Ala Gln Leu Thr Ser Thr Arg Leu Arg Arg Asn Thr Ser Val 
            180                 185                 190         


Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Ala Cys Glu Gln Gln 
        195                 200                 205             


Tyr Asp Ser Ser Tyr Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile 
    210                 215                 220                 


Thr Ala Ile Glu Leu Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His 
225                 230                 235                 240 


Pro Val Lys Thr Leu Phe Lys Ile Pro Arg Asn Pro Pro Pro Thr Leu 
                245                 250                 255     


Leu His Pro Glu Lys Trp Cys Glu Glu Phe Asn His Phe Ile Ser Gln 
            260                 265                 270         


Cys Leu Ile Lys Asp Phe Glu Arg Arg Pro Ser Val Thr His Leu Leu 
        275                 280                 285             


Asp His Pro Phe Ile Lys Gly Val His Gly Lys Val Leu Phe Leu Gln 
    290                 295                 300                 


Lys Gln Leu Ala Lys Val Leu Gln Asp Gln Lys His Gln Asn Pro Val 
305                 310                 315                 320 


Ala Lys Thr Arg His Glu Arg Met His Thr Arg Arg Pro Tyr His Val 
                325                 330                 335     


Glu Asp Ala Glu Lys Tyr Cys Leu Glu Asp Asp Leu Val Asn Leu Glu 
            340                 345                 350         


Val Leu Asp Glu Asp Thr Ile Ile His Gln Leu Gln Lys Arg Tyr Ala 
        355                 360                 365             


Asp Leu Leu Ile Tyr Thr Tyr Val Gly Asp Ile Leu Ile Ala Leu Asn 
    370                 375                 380                 


Pro Phe Gln Asn Leu Ser Ile Tyr Ser Pro Gln Phe Ser Arg Leu Tyr 
385                 390                 395                 400 


His Gly Val Lys Arg Ala Ser Asn Pro Pro His Ile Phe Ala Ser Ala 
                405                 410                 415     


Asp Ala Ala Tyr Gln Cys Met Val Thr Leu Ser Lys Asp Gln Cys Ile 
            420                 425                 430         


Val Ile Ser Gly Glu Ser Gly Ser Gly Lys Thr Glu Ser Ala His Leu 
        435                 440                 445             


Ile Val Gln His Leu Thr Phe Leu Gly Lys Ala Asn Asn Gln Thr Leu 
    450                 455                 460                 


Arg Glu Lys Ile Leu Gln Val Asn Ser Leu Val Glu Ala Phe Gly Asn 
465                 470                 475                 480 


Ser Cys Thr Ala Ile Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Leu 
                485                 490                 495     


Glu Met Met Phe Thr Pro Thr Gly Val Val Met Gly Ala Arg Ile Ser 
            500                 505                 510         


Glu Tyr Leu Leu Glu Lys Ser Arg Val Ile Lys Gln Ala Ala Arg Glu 
        515                 520                 525             


Lys Asn Phe His Ile Phe Tyr Tyr Ile Tyr Ala Gly Leu His His Gln 
    530                 535                 540                 


Lys Lys Leu Ser Asp Phe Arg Leu Pro Glu Glu Lys Pro Pro Arg Tyr 
545                 550                 555                 560 


Ile Ala Asp Glu Thr Gly Arg Val Met His Asp Ile Thr Ser Lys Glu 
                565                 570                 575     


Ser Tyr Arg Arg Gln Phe Glu Ala Ile Gln His Cys Phe Arg Ile Ile 
            580                 585                 590         


Gly Phe Thr Asp Lys Glu Val His Ser Val Tyr Arg Ile Leu Ala Gly 
        595                 600                 605             


Ile Leu Asn Ile Gly Asn Ile Glu Phe Ala Ala Ile Ser Ser Gln His 
    610                 615                 620                 


Gln Thr Asp Lys Ser Glu Val Pro Asn Ala Glu Ala Leu Gln Asn Ala 
625                 630                 635                 640 


Ala Ser Val Leu Cys Ile Ser Pro Glu Glu Leu Gln Glu Ala Leu Thr 
                645                 650                 655     


Ser His Cys Val Val Thr Arg Gly Glu Thr Ile Ile Arg Ala Asn Thr 
            660                 665                 670         


Val Asp Arg Ala Ala Asp Val Arg Asp Ala Met Ser Lys Ala Leu Tyr 
        675                 680                 685             


Gly Arg Leu Phe Ser Trp Ile Val Asn Arg Ile Asn Thr Leu Leu Gln 
    690                 695                 700                 


Pro Asp Glu Asn Ile Cys Ser Ala Gly Gly Gly Met Asn Val Gly Ile 
705                 710                 715                 720 


Leu Asp Ile Phe Gly Phe Glu Asn Phe Gln Arg Asn Ser Phe Glu Gln 
                725                 730                 735     


Leu Cys Ile Asn Ile Ala Asn Glu Gln Ile Gln Tyr Tyr Phe Asn Gln 
            740                 745                 750         


His Val Phe Ala Leu Glu Gln Met Glu Tyr Gln Asn Glu Gly Ile Asp 
        755                 760                 765             


Ala Val Pro Val Glu Tyr Glu Asp Asn Arg Pro Leu Leu Asp Met Phe 
    770                 775                 780                 


Leu Gln Lys Pro Leu Gly Leu Leu Ala Leu Leu Asp Glu Glu Ser Arg 
785                 790                 795                 800 


Phe Pro Gln Ala Thr Asp Gln Thr Leu Val Asp Lys Phe Glu Asp Asn 
                805                 810                 815     


Leu Arg Cys Lys Tyr Phe Trp Arg Pro Lys Gly Val Glu Leu Cys Phe 
            820                 825                 830         


Gly Ile Gln His Tyr Ala Gly Lys Val Leu Tyr Asp Ala Ser Gly Val 
        835                 840                 845             


Leu Glu Lys Asn Arg Asp Thr Leu Pro Ala Asp Val Val Val Val Leu 
    850                 855                 860                 


Arg Thr Ser Glu Asn Lys Leu Leu Gln Gln Leu Phe Ser Ile Pro Leu 
865                 870                 875                 880 


Thr Lys Thr Gly Asn Leu Ala Gln Thr Arg Ala Arg Ile Thr Val Ala 
                885                 890                 895     


Ser Ser Ser Leu Pro Pro His Phe Ser Ala Gly Lys Ala Lys Val Asp 
            900                 905                 910         


Thr Leu Glu Val Ile Arg His Pro Glu Glu Thr Thr Asn Met Lys Arg 
        915                 920                 925             


Gln Thr Val Ala Ser Tyr Phe Arg Tyr Ser Leu Met Asp Leu Leu Ser 
    930                 935                 940                 


Lys Met Val Val Gly Gln Pro His Phe Val Arg Cys Ile Lys Pro Asn 
945                 950                 955                 960 


Asp Asp Arg Glu Ala Leu Gln Phe Ser Arg Glu Arg Val Leu Ala Gln 
                965                 970                 975     


Leu Arg Ser Thr Gly Ile Leu Glu Thr Val Ser Ile Arg Arg Gln Gly 
            980                 985                 990         


Tyr Ser His Arg Ile Leu Phe Glu  Glu Phe Val Lys Arg  Tyr Tyr Tyr 
        995                 1000                 1005             


Leu Ala  Phe Thr Ala His Gln  Thr Pro Leu Ala Ser  Lys Glu Ser 
    1010                 1015                 1020             


Cys Val  Ala Ile Leu Glu Lys  Ser Arg Leu Asp His  Trp Val Leu 
    1025                 1030                 1035             


Gly Lys  Thr Lys Val Phe Leu  Lys Tyr Tyr His Val  Glu Gln Leu 
    1040                 1045                 1050             


Asn Leu  Leu Leu Arg Glu Val  Ile Gly Arg Val Val  Val Leu Gln 
    1055                 1060                 1065             


Ala Tyr  Thr Lys Gly Trp Leu  Gly Ala Arg Arg Tyr  Lys Arg Val 
    1070                 1075                 1080             


Arg Glu  Lys Arg Glu Lys Gly  Ala Ile Ala Ile Gln  Ser Ala Trp 
    1085                 1090                 1095             


Arg Gly  Tyr Asp Ala Arg Arg  Lys Phe Lys Lys Ile  Ser Asn Arg 
    1100                 1105                 1110             


Arg Asn  Glu Ser Ala Ala His  Asn Gln Ala Gly Asp  Thr Ser Asn 
    1115                 1120                 1125             


Gln Ser  Ser Gly Pro His Ser  Pro Val Ala Ala Gly  Thr Arg Gly 
    1130                 1135                 1140             


Ser Ala  Glu Val Gln Asp Cys  Ser Glu Pro Gly Asp  His Lys Val 
    1145                 1150                 1155             


Leu Arg  Gly Ser Val His Arg  Arg Ser His Ser Gln  Ala Glu Ser 
    1160                 1165                 1170             


Asn Asn  Gly Arg Thr Gln Thr  Ser Ser Asn Ser Pro  Ala Val Thr 
    1175                 1180                 1185             


Glu Lys  Asn Gly Trp Ser Phe  Thr Leu Leu Leu Arg  Leu Glu Cys 
    1190                 1195                 1200             


Asn Ser  Met Ile Ser Ala Asp  Cys Asn Leu Arg Pro  Leu Gly Ser 
    1205                 1210                 1215             


Ser Asp  Ser Pro Ala Ser Ala  Ser Arg Val Ala Gly  Ile Thr Gly 
    1220                 1225                 1230             


Ile His  Lys Pro Arg Val Leu  Gln Lys Gly Ala Ile  Ser Ser Gln 
    1235                 1240                 1245             


Asp Met  Gln Thr Ser Thr Arg  Phe Leu Gly Leu Ile  Cys Cys Leu 
    1250                 1255                 1260             


Leu Gly  Tyr Ala Ile Leu Leu  Gln Ile Ser Lys Asp  
    1265                 1270                 1275 


<210>  8694
<211>  5440
<212>  DNA
<213>  Homosapiens

<400>  8694
ctagatcgaa agtcctttgg taatgatgtg tcatacattc tagtcatcaa agacaccatt     60

ttctgggcct gaagtgttct gctggttttt ggaggaatga gaatccaatc tctcataagc    120

cggattcaga aaataggtca tcgatgaaac atctgtatgg attatttcac tataatccta    180

tgatgcttgg acttgaatca cttccagatc ccacagacac ctgggaaatt atagagacca    240

ttggtaaagg cacctatggc aaagtctaca aggtaactaa caagagagat gggagcctgg    300

ctgcagtgaa aattctggat ccagtcagtg atatggatga agaaattgag gcagaataca    360

acattttgca gttccttcct aatcatccca atgttgtaaa gttttatggg atgttttaca    420

aagcggatca ctgtgtaggg ggacagctgt ggctggtcct ggagctgtgt aatgggggct    480

cagtcactga gcttgtcaaa ggtctactca gatgtggcca gcggttggat gaagcaatga    540

tctcatacat cttgtacggg gccctcttgg gccttcagca tttgcacaac aaccgaatca    600

tccaccgtga tgtgaagggg aataacattc ttctgacaac agaaggagga gttaagctcg    660

ttgactttgg tgtttcagct caactcacca gtacacgtct gcggagaaac acatctgttg    720

gcaccccgtt ctggatggcc cctgaggtca ttgcctgtga gcagcagtat gactcttcct    780

atgacgctcg ctgtgacgtc tggtccttgg ggatcacagc tattgaactg ggggatggag    840

accctcccct ctttgacatg catcctgtga aaacactctt taagattcca agaaatcctc    900

cacctacttt acttcatcca gaaaaatggt gtgaagaatt caaccacttt atttcacagt    960

gtcttattaa ggattttgaa aggcgacctt ccgtcacaca tctccttgac cacccattta   1020

ttaaaggagt acatggaaaa gttctgtttc tgcaaaaaca gctggccaag gttctccaag   1080

accagaagca tcaaaatcct gttgctaaaa ccaggcatga gaggatgcat accagaagac   1140

cttatcatgt ggaagatgct gaaaaatact gccttgagga tgatttggtc aacctagagg   1200

ttctggatga ggatacaatt atccatcagt tgcagaaacg ttatgcagac ttgctaattt   1260

acacatatgt tggagacatc ttaattgcct taaacccctt ccagaatcta agcatatact   1320

ctccacagtt ttccagactt tatcatgggg tgaaacgcgc ctccaatccc ccccacatat   1380

ttgcatcagc agatgctgct taccagtgca tggttactct cagcaaagac cagtgcattg   1440

tcatcagcgg agagagtggc tctgggaaga cagaaagcgc ccacctgatt gttcagcatt   1500

tgactttctt gggaaaggcc aataatcaga ccttgagaga gaaaattcta caagtcaact   1560

ccctggtgga agcctttggg aactcatgca ctgccatcaa tgacaactcg agccgttttg   1620

gaaaatatct ggaaatgatg tttacaccaa ctggagttgt gatgggggca agaatctctg   1680

aatatctcct ggaaaaatcc agagttataa aacaggcagc gagagagaaa aattttcata   1740

tattttacta tatttatgct ggtcttcatc accaaaagaa gctttctgat ttcagacttc   1800

ctgaggaaaa acctcctagg tacatagctg atgaaactgg aagggtgatg cacgacataa   1860

cttccaagga gtcttacaga agacaattcg aagcaattca gcattgcttc aggattatag   1920

ggttcacgga caaagaggtg cactcagtgt acagaatttt ggctgggatt ttgaatattg   1980

ggaacattga gttcgcagct atttcctctc aacatcagac tgataaaagt gaggtgccca   2040

atgctgaagc tttgcaaaat gctgcctctg ttctgtgcat tagccctgaa gagctccagg   2100

aggccctcac ctcccactgt gtggtcaccc ggggcgagac catcatccgt gccaacactg   2160

tagacagggc tgcggacgtt cgagacgcca tgtccaaagc cctgtatggg aggctcttca   2220

gctggattgt gaatcgcatt aatacactcc tgcagccaga cgaaaacata tgtagtgcag   2280

gaggtggaat gaatgtgggg atcttggata tctttggatt cgagaatttt cagagaaatt   2340

catttgagca gctctgcata aacatcgcca atgagcaaat ccagtactat ttcaatcagc   2400

atgtttttgc tcttgagcag atggaatatc agaatgaagg cattgatgct gtacccgtgg   2460

aatatgagga caaccgcccg ctcttggaca tgttcctcca gaaacccctg ggactgcttg   2520

cacttttgga tgaggaaagt cggtttcccc aagcaactga ccagaccctg gttgataaat   2580

ttgaagataa tctacgatgc aaatacttct ggaggcccaa aggagtggaa ctgtgctttg   2640

gcattcagca ttatgctgga aaggtattat atgatgcttc tggggttctt gagaaaaata   2700

gagacactct ccctgccgat gtggttgtgg tcctgagaac gtcagaaaac aagcttcttc   2760

agcagctctt ctcaatccct ctgaccaaaa caggtaattt ggcccagaca agagctagga   2820

taacagtggc ctcaagttct ttgcctccac atttcagtgc tgggaaagcc aaggtggaca   2880

ctctggaggt gatacggcat ccggaagaaa ccaccaacat gaagaggcaa actgtggctt   2940

cttacttccg gtattctctg atggacctgc tctccaaaat ggtggttgga cagccccact   3000

ttgtgcgctg cattaaaccc aatgatgacc gagaggccct gcagttctct cgagagaggg   3060

tgctggccca gctccgctcc acagggattc tggagacagt cagcatccgc cgccagggct   3120

attcccaccg catccttttt gaagaatttg tgaaaaggta ttattacttg gcattcacag   3180

cacatcaaac acctcttgct agcaaagaga gctgtgtggc tatcttggaa aagtccagat   3240

tagatcactg ggtactggga aaaacaaagg tttttctcaa atattaccat gttgagcaat   3300

taaatttgct gcttcgagaa gtcataggca gagtggttgt gctgcaggca tataccaagg   3360

ggtggcttgg agccaggaga tacaaaaggg tcagagagaa gagagagaag ggagccattg   3420

ccatccagtc aggggacact tcaaaccaaa gcagtgggcc acattccccc gtcgcagcag   3480

gtacgagggg aagtgccgag gttcaagact gcagcgagcc tggtgaccat aaagttctca   3540

ggggctctgt acatcgtagg agccattcac aagcagaatc caacaatggc cgtacacaga   3600

cttcaagcaa ctctcctgct gtcacagaga aaaatgggca ttcacaagcc cagagttctc   3660

caaaagggtg cgatatcttc gcaggacatg caaacaagca ctcggtttct gggactgatt   3720

tgctgtcttc tcggatatgc catcctgctc cagatcagca aggattgagt ctctggggag   3780

cccctcaaaa gcctggttca gaaaatggtc ttgcacagaa gcatcgaaca cctcgccgac   3840

gatgtcagca gcccaaaatg ctgagtagcc ctgaggacac catgtactat aaccagttaa   3900

atggaactct agaatatcaa gggagcaaga ggaagccaag aaaacttggc caaatcaaag   3960

tacttgatgg ggaagatgaa tattacaaat ctctgtcacc agtggactgt atccctgagg   4020

agaacaactc agcccaccct tccttttttt cttcatcctc aaaaggagac tcttttgctc   4080

aacattaaat tgtgcttcct aaccctaaat ctgtccagag taggaacatt catggtaatc   4140

gactgtctgt cattgcgtaa gaaagcactg atatggggtc agcttctttg gacatatggt   4200

ccatgcctga accttactga accacttgca gattccaaaa catcttatcc tatcctctac   4260

cactctccca catgtgttgt gcagcctgag ctgggcgctg ccttcctttc tcatcccatg   4320

gggccctgtg ggacactgag aacaccttta caatagttta aacagtcatt catgccccca   4380

gtgtctagga agataacagc cagtctcacc ccagtctaat catggaccct gataatattg   4440

cttgattttt cctatcaagt tacttttcaa tccattcaga atctgcccca gtggagaccc   4500

aggagttcct ttcctgcact cttctccatc ctcccacctt tgctgggctt ttctatcact   4560

cccacctccc ccagagtcag ggctccattg ctgagtgccc catcctggag gattggcccc   4620

aagatctcct agaacaggat aattgcctgt gtttaggcag ataggcctaa atctttcaga   4680

ttctttctac aaggcaaata acccctctct tgttaattat gatgctgaga aagcctctgt   4740

ctctttattt caccttgcca agacacccac actactttgg tgatgaaaag aaaggaatga   4800

gagggaaagt ttggacctgt cactttggtg acagggaaag tccaggtcac tttattctgt   4860

aactctccat tcactggtca aataactcca tgaggctatc agtggctaca gtggaaggac   4920

ctgatcttgt ccatctttgt gtgcacagag cctagcacag ggcttggtag agggtatatc   4980

tagtgaatgg agaatacatg gagaaactta actaagttac acaagcatat ctgacaggaa   5040

tgttaccttc aattgtatgt tacatatgat tagtcacttt tcatacacta taacctctga   5100

tttttcactc aagtttgggc tgattatatt gtaatgatgt tagataatac tcaacatgat   5160

tcagtatgac aaactttttt gagcacctac tttatataaa acatgacaaa ttgcagtgtg   5220

atgtaatcaa aaacaaagaa gccctataag accatttctc tagaacagat gttcttaata   5280

tttttcttac tctaaaatat gtggtagata gtatgcaaga aaagccgggt gcggtggctc   5340

aggcctgtaa tcccagcact ttgggaggcc aagatgggcg gatcatgaag tcaggagttc   5400

gagaccagcc tgaccaacat ggtgaaaccc cgtctctact                         5440


<210>  8695
<211>  1314
<212>  PRT
<213>  Homosapiens

<400>  8695

Met Lys His Leu Tyr Gly Leu Phe His Tyr Asn Pro Met Met Leu Gly 
1               5                   10                  15      


Leu Glu Ser Leu Pro Asp Pro Thr Asp Thr Trp Glu Ile Ile Glu Thr 
            20                  25                  30          


Ile Gly Lys Gly Thr Tyr Gly Lys Val Tyr Lys Val Thr Asn Lys Arg 
        35                  40                  45              


Asp Gly Ser Leu Ala Ala Val Lys Ile Leu Asp Pro Val Ser Asp Met 
    50                  55                  60                  


Asp Glu Glu Ile Glu Ala Glu Tyr Asn Ile Leu Gln Phe Leu Pro Asn 
65                  70                  75                  80  


His Pro Asn Val Val Lys Phe Tyr Gly Met Phe Tyr Lys Ala Asp His 
                85                  90                  95      


Cys Val Gly Gly Gln Leu Trp Leu Val Leu Glu Leu Cys Asn Gly Gly 
            100                 105                 110         


Ser Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys Gly Gln Arg Leu 
        115                 120                 125             


Asp Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala Leu Leu Gly Leu 
    130                 135                 140                 


Gln His Leu His Asn Asn Arg Ile Ile His Arg Asp Val Lys Gly Asn 
145                 150                 155                 160 


Asn Ile Leu Leu Thr Thr Glu Gly Gly Val Lys Leu Val Asp Phe Gly 
                165                 170                 175     


Val Ser Ala Gln Leu Thr Ser Thr Arg Leu Arg Arg Asn Thr Ser Val 
            180                 185                 190         


Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Ala Cys Glu Gln Gln 
        195                 200                 205             


Tyr Asp Ser Ser Tyr Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile 
    210                 215                 220                 


Thr Ala Ile Glu Leu Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His 
225                 230                 235                 240 


Pro Val Lys Thr Leu Phe Lys Ile Pro Arg Asn Pro Pro Pro Thr Leu 
                245                 250                 255     


Leu His Pro Glu Lys Trp Cys Glu Glu Phe Asn His Phe Ile Ser Gln 
            260                 265                 270         


Cys Leu Ile Lys Asp Phe Glu Arg Arg Pro Ser Val Thr His Leu Leu 
        275                 280                 285             


Asp His Pro Phe Ile Lys Gly Val His Gly Lys Val Leu Phe Leu Gln 
    290                 295                 300                 


Lys Gln Leu Ala Lys Val Leu Gln Asp Gln Lys His Gln Asn Pro Val 
305                 310                 315                 320 


Ala Lys Thr Arg His Glu Arg Met His Thr Arg Arg Pro Tyr His Val 
                325                 330                 335     


Glu Asp Ala Glu Lys Tyr Cys Leu Glu Asp Asp Leu Val Asn Leu Glu 
            340                 345                 350         


Val Leu Asp Glu Asp Thr Ile Ile His Gln Leu Gln Lys Arg Tyr Ala 
        355                 360                 365             


Asp Leu Leu Ile Tyr Thr Tyr Val Gly Asp Ile Leu Ile Ala Leu Asn 
    370                 375                 380                 


Pro Phe Gln Asn Leu Ser Ile Tyr Ser Pro Gln Phe Ser Arg Leu Tyr 
385                 390                 395                 400 


His Gly Val Lys Arg Ala Ser Asn Pro Pro His Ile Phe Ala Ser Ala 
                405                 410                 415     


Asp Ala Ala Tyr Gln Cys Met Val Thr Leu Ser Lys Asp Gln Cys Ile 
            420                 425                 430         


Val Ile Ser Gly Glu Ser Gly Ser Gly Lys Thr Glu Ser Ala His Leu 
        435                 440                 445             


Ile Val Gln His Leu Thr Phe Leu Gly Lys Ala Asn Asn Gln Thr Leu 
    450                 455                 460                 


Arg Glu Lys Ile Leu Gln Val Asn Ser Leu Val Glu Ala Phe Gly Asn 
465                 470                 475                 480 


Ser Cys Thr Ala Ile Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Leu 
                485                 490                 495     


Glu Met Met Phe Thr Pro Thr Gly Val Val Met Gly Ala Arg Ile Ser 
            500                 505                 510         


Glu Tyr Leu Leu Glu Lys Ser Arg Val Ile Lys Gln Ala Ala Arg Glu 
        515                 520                 525             


Lys Asn Phe His Ile Phe Tyr Tyr Ile Tyr Ala Gly Leu His His Gln 
    530                 535                 540                 


Lys Lys Leu Ser Asp Phe Arg Leu Pro Glu Glu Lys Pro Pro Arg Tyr 
545                 550                 555                 560 


Ile Ala Asp Glu Thr Gly Arg Val Met His Asp Ile Thr Ser Lys Glu 
                565                 570                 575     


Ser Tyr Arg Arg Gln Phe Glu Ala Ile Gln His Cys Phe Arg Ile Ile 
            580                 585                 590         


Gly Phe Thr Asp Lys Glu Val His Ser Val Tyr Arg Ile Leu Ala Gly 
        595                 600                 605             


Ile Leu Asn Ile Gly Asn Ile Glu Phe Ala Ala Ile Ser Ser Gln His 
    610                 615                 620                 


Gln Thr Asp Lys Ser Glu Val Pro Asn Ala Glu Ala Leu Gln Asn Ala 
625                 630                 635                 640 


Ala Ser Val Leu Cys Ile Ser Pro Glu Glu Leu Gln Glu Ala Leu Thr 
                645                 650                 655     


Ser His Cys Val Val Thr Arg Gly Glu Thr Ile Ile Arg Ala Asn Thr 
            660                 665                 670         


Val Asp Arg Ala Ala Asp Val Arg Asp Ala Met Ser Lys Ala Leu Tyr 
        675                 680                 685             


Gly Arg Leu Phe Ser Trp Ile Val Asn Arg Ile Asn Thr Leu Leu Gln 
    690                 695                 700                 


Pro Asp Glu Asn Ile Cys Ser Ala Gly Gly Gly Met Asn Val Gly Ile 
705                 710                 715                 720 


Leu Asp Ile Phe Gly Phe Glu Asn Phe Gln Arg Asn Ser Phe Glu Gln 
                725                 730                 735     


Leu Cys Ile Asn Ile Ala Asn Glu Gln Ile Gln Tyr Tyr Phe Asn Gln 
            740                 745                 750         


His Val Phe Ala Leu Glu Gln Met Glu Tyr Gln Asn Glu Gly Ile Asp 
        755                 760                 765             


Ala Val Pro Val Glu Tyr Glu Asp Asn Arg Pro Leu Leu Asp Met Phe 
    770                 775                 780                 


Leu Gln Lys Pro Leu Gly Leu Leu Ala Leu Leu Asp Glu Glu Ser Arg 
785                 790                 795                 800 


Phe Pro Gln Ala Thr Asp Gln Thr Leu Val Asp Lys Phe Glu Asp Asn 
                805                 810                 815     


Leu Arg Cys Lys Tyr Phe Trp Arg Pro Lys Gly Val Glu Leu Cys Phe 
            820                 825                 830         


Gly Ile Gln His Tyr Ala Gly Lys Val Leu Tyr Asp Ala Ser Gly Val 
        835                 840                 845             


Leu Glu Lys Asn Arg Asp Thr Leu Pro Ala Asp Val Val Val Val Leu 
    850                 855                 860                 


Arg Thr Ser Glu Asn Lys Leu Leu Gln Gln Leu Phe Ser Ile Pro Leu 
865                 870                 875                 880 


Thr Lys Thr Gly Asn Leu Ala Gln Thr Arg Ala Arg Ile Thr Val Ala 
                885                 890                 895     


Ser Ser Ser Leu Pro Pro His Phe Ser Ala Gly Lys Ala Lys Val Asp 
            900                 905                 910         


Thr Leu Glu Val Ile Arg His Pro Glu Glu Thr Thr Asn Met Lys Arg 
        915                 920                 925             


Gln Thr Val Ala Ser Tyr Phe Arg Tyr Ser Leu Met Asp Leu Leu Ser 
    930                 935                 940                 


Lys Met Val Val Gly Gln Pro His Phe Val Arg Cys Ile Lys Pro Asn 
945                 950                 955                 960 


Asp Asp Arg Glu Ala Leu Gln Phe Ser Arg Glu Arg Val Leu Ala Gln 
                965                 970                 975     


Leu Arg Ser Thr Gly Ile Leu Glu Thr Val Ser Ile Arg Arg Gln Gly 
            980                 985                 990         


Tyr Ser His Arg Ile Leu Phe Glu  Glu Phe Val Lys Arg  Tyr Tyr Tyr 
        995                 1000                 1005             


Leu Ala  Phe Thr Ala His Gln  Thr Pro Leu Ala Ser  Lys Glu Ser 
    1010                 1015                 1020             


Cys Val  Ala Ile Leu Glu Lys  Ser Arg Leu Asp His  Trp Val Leu 
    1025                 1030                 1035             


Gly Lys  Thr Lys Val Phe Leu  Lys Tyr Tyr His Val  Glu Gln Leu 
    1040                 1045                 1050             


Asn Leu  Leu Leu Arg Glu Val  Ile Gly Arg Val Val  Val Leu Gln 
    1055                 1060                 1065             


Ala Tyr  Thr Lys Gly Trp Leu  Gly Ala Arg Arg Tyr  Lys Arg Val 
    1070                 1075                 1080             


Arg Glu  Lys Arg Glu Lys Gly  Ala Ile Ala Ile Gln  Ser Gly Asp 
    1085                 1090                 1095             


Thr Ser  Asn Gln Ser Ser Gly  Pro His Ser Pro Val  Ala Ala Gly 
    1100                 1105                 1110             


Thr Arg  Gly Ser Ala Glu Val  Gln Asp Cys Ser Glu  Pro Gly Asp 
    1115                 1120                 1125             


His Lys  Val Leu Arg Gly Ser  Val His Arg Arg Ser  His Ser Gln 
    1130                 1135                 1140             


Ala Glu  Ser Asn Asn Gly Arg  Thr Gln Thr Ser Ser  Asn Ser Pro 
    1145                 1150                 1155             


Ala Val  Thr Glu Lys Asn Gly  His Ser Gln Ala Gln  Ser Ser Pro 
    1160                 1165                 1170             


Lys Gly  Cys Asp Ile Phe Ala  Gly His Ala Asn Lys  His Ser Val 
    1175                 1180                 1185             


Ser Gly  Thr Asp Leu Leu Ser  Ser Arg Ile Cys His  Pro Ala Pro 
    1190                 1195                 1200             


Asp Gln  Gln Gly Leu Ser Leu  Trp Gly Ala Pro Gln  Lys Pro Gly 
    1205                 1210                 1215             


Ser Glu  Asn Gly Leu Ala Gln  Lys His Arg Thr Pro  Arg Arg Arg 
    1220                 1225                 1230             


Cys Gln  Gln Pro Lys Met Leu  Ser Ser Pro Glu Asp  Thr Met Tyr 
    1235                 1240                 1245             


Tyr Asn  Gln Leu Asn Gly Thr  Leu Glu Tyr Gln Gly  Ser Lys Arg 
    1250                 1255                 1260             


Lys Pro  Arg Lys Leu Gly Gln  Ile Lys Val Leu Asp  Gly Glu Asp 
    1265                 1270                 1275             


Glu Tyr  Tyr Lys Ser Leu Ser  Pro Val Asp Cys Ile  Pro Glu Glu 
    1280                 1285                 1290             


Asn Asn  Ser Ala His Pro Ser  Phe Phe Ser Ser Ser  Ser Lys Gly 
    1295                 1300                 1305             


Asp Ser  Phe Ala Gln His 
    1310                 


<210>  8696
<211>  5552
<212>  DNA
<213>  Homosapiens

<400>  8696
ctagatcgaa agtcctttgg taatgatgtg tcatacattc tagtcatcaa agacaccatt     60

ttctgggcct gaagtgttct gctggttttt ggaggaatga gaatccaatc tctcataagc    120

cggattcaga aaataggtca tcgatgaaac atctgtatgg attatttcac tataatccta    180

tgatgcttgg acttgaatca cttccagatc ccacagacac ctgggaaatt atagagacca    240

ttggtaaagg cacctatggc aaagtctaca aggtaactaa caagagagat gggagcctgg    300

ctgcagtgaa aattctggat ccagtcagtg atatggatga agaaattgag gcagaataca    360

acattttgca gttccttcct aatcatccca atgttgtaaa gttttatggg atgttttaca    420

aagcggatca ctgtgtaggg ggacagctgt ggctggtcct ggagctgtgt aatgggggct    480

cagtcactga gcttgtcaaa ggtctactca gatgtggcca gcggttggat gaagcaatga    540

tctcatacat cttgtacggg gccctcttgg gccttcagca tttgcacaac aaccgaatca    600

tccaccgtga tgtgaagggg aataacattc ttctgacaac agaaggagga gttaagctcg    660

ttgactttgg tgtttcagct caactcacca gtacacgtct gcggagaaac acatctgttg    720

gcaccccgtt ctggatggcc cctgaggtca ttgcctgtga gcagcagtat gactcttcct    780

atgacgctcg ctgtgacgtc tggtccttgg ggatcacagc tattgaactg ggggatggag    840

accctcccct ctttgacatg catcctgtga aaacactctt taagattcca agaaatcctc    900

cacctacttt acttcatcca gaaaaatggt gtgaagaatt caaccacttt atttcacagt    960

gtcttattaa ggattttgaa aggcgacctt ccgtcacaca tctccttgac cacccattta   1020

ttaaaggagt acatggaaaa gttctgtttc tgcaaaaaca gctggccaag gttctccaag   1080

accagaagca tcaaaatcct gttgctaaaa ccaggcatga gaggatgcat accagaagac   1140

cttatcatgt ggaagatgct gaaaaatact gccttgagga tgatttggtc aacctagagg   1200

ttctggatga ggatacaatt atccatcagt tgcagaaacg ttatgcagac ttgctaattt   1260

acacatatgt tggagacatc ttaattgcct taaacccctt ccagaatcta agcatatact   1320

ctccacagtt ttccagactt tatcatgggg tgaaacgcgc ctccaatccc ccccacatat   1380

ttgcatcagc agatgctgct taccagtgca tggttactct cagcaaagac cagtgcattg   1440

tcatcagcgg agagagtggc tctgggaaga cagaaagcgc ccacctgatt gttcagcatt   1500

tgactttctt gggaaaggcc aataatcaga ccttgagaga gaaaattcta caagtcaact   1560

ccctggtgga agcctttggg aactcatgca ctgccatcaa tgacaactcg agccgttttg   1620

gaaaatatct ggaaatgatg tttacaccaa ctggagttgt gatgggggca agaatctctg   1680

aatatctcct ggaaaaatcc agagttataa aacaggcagc gagagagaaa aattttcata   1740

tattttacta tatttatgct ggtcttcatc accaaaagaa gctttctgat ttcagacttc   1800

ctgaggaaaa acctcctagg tacatagctg atgaaactgg aagggtgatg cacgacataa   1860

cttccaagga gtcttacaga agacaattcg aagcaattca gcattgcttc aggattatag   1920

ggttcacgga caaagaggtg cactcagtgt acagaatttt ggctgggatt ttgaatattg   1980

ggaacattga gttcgcagct atttcctctc aacatcagac tgataaaagt gaggtgccca   2040

atgctgaagc tttgcaaaat gctgcctctg ttctgtgcat tagccctgaa gagctccagg   2100

aggccctcac ctcccactgt gtggtcaccc ggggcgagac catcatccgt gccaacactg   2160

tagacagggc tgcggacgtt cgagacgcca tgtccaaagc cctgtatggg aggctcttca   2220

gctggattgt gaatcgcatt aatacactcc tgcagccaga cgaaaacata tgtagtgcag   2280

gaggtggaat gaatgtgggg atcttggata tctttggatt cgagaatttt cagagaaatt   2340

catttgagca gctctgcata aacatcgcca atgagcaaat ccagtactat ttcaatcagc   2400

atgtttttgc tcttgagcag atggaatatc agaatgaagg cattgatgct gtacccgtgg   2460

aatatgagga caaccgcccg ctcttggaca tgttcctcca gaaacccctg ggactgcttg   2520

cacttttgga tgaggaaagt cggtttcccc aagcaactga ccagaccctg gttgataaat   2580

ttgaagataa tctacgatgc aaatacttct ggaggcccaa aggagtggaa ctgtgctttg   2640

gcattcagca ttatgctgga aaggtattat atgatgcttc tggggttctt gagaaaaata   2700

gagacactct ccctgccgat gtggttgtgg tcctgagaac gtcagaaaac aagcttcttc   2760

agcagctctt ctcaatccct ctgaccaaaa caggtaattt ggcccagaca agagctagga   2820

taacagtggc ctcaagttct ttgcctccac atttcagtgc tgggaaagcc aaggtggaca   2880

ctctggaggt gatacggcat ccggaagaaa ccaccaacat gaagaggcaa actgtggctt   2940

cttacttccg gtattctctg atggacctgc tctccaaaat ggtggttgga cagccccact   3000

ttgtgcgctg cattaaaccc aatgatgacc gagaggccct gcagttctct cgagagaggg   3060

tgctggccca gctccgctcc acagggattc tggagacagt cagcatccgc cgccagggct   3120

attcccaccg catccttttt gaagaatttg tgaaaaggta ttattacttg gcattcacag   3180

cacatcaaac acctcttgct agcaaagaga gctgtgtggc tatcttggaa aagtccagat   3240

tagatcactg ggtactggga aaaacaaagg tttttctcaa atattaccat gttgagcaat   3300

taaatttgct gcttcgagaa gtcataggca gagtggttgt gctgcaggca tataccaagg   3360

ggtggcttgg agccaggaga tacaaaaggg tcagagagaa gagagagaag ggagccattg   3420

ccatccagtc agcctggaga ggatatgatg ctcggaggaa atttaagaaa ataagcaaca   3480

gaaggaatga gtctgctgct cataatcaag caggggacac ttcaaaccaa agcagtgggc   3540

cacattcccc cgtcgcagca ggtacgaggg gaagtgccga ggttcaagac tgcagcgagc   3600

ctggtgacca taaagttctc aggggctctg tacatcgtag gagccattca caagcagaat   3660

ccaacaatgg ccgtacacag acttcaagca actctcctgc tgtcacagag aaaaatgggc   3720

attcacaagc ccagagttct ccaaaagggt gcgatatctt cgcaggacat gcaaacaagc   3780

actcggtttc tgggactgat ttgctgtctt ctcggatatg ccatcctgct ccagatcagc   3840

aaggattgag tctctgggga gcccctcaaa agcctgcctt tccacattac ggatgtaact   3900

tttatgggtt cagaaaatgg tcttgcacag aagcatcgaa cacctcgccg acgatgtcag   3960

cagcccaaaa tgctgagtag ccctgaggac accatgtact ataaccagtt aaatggaact   4020

ctagaatatc aagggagcaa gaggaagcca agaaaacttg gccaaatcaa agtacttgat   4080

ggggaagatg aatattacaa atctctgtca ccagtggact gtatccctga ggagaacaac   4140

tcagcccacc cttccttttt ttcttcatcc tcaaaaggag actcttttgc tcaacattaa   4200

attgtgcttc ctaaccctaa atctgtccag agtaggaaca ttcatggtaa tcgactgtct   4260

gtcattgcgt aagaaagcac tgatatgggg tcagcttctt tggacatatg gtccatgcct   4320

gaaccttact gaaccacttg cagattccaa aacatcttat cctatcctct accactctcc   4380

cacatgtgtt gtgcagcctg agctgggcgc tgccttcctt tctcatccca tggggccctg   4440

tgggacactg agaacacctt tacaatagtt taaacagtca ttcatgcccc cagtgtctag   4500

gaagataaca gccagtctca ccccagtcta atcatggacc ctgataatat tgcttgattt   4560

ttcctatcaa gttacttttc aatccattca gaatctgccc cagtggagac ccaggagttc   4620

ctttcctgca ctcttctcca tcctcccacc tttgctgggc ttttctatca ctcccacctc   4680

ccccagagtc agggctccat tgctgagtgc cccatcctgg aggattggcc ccaagatctc   4740

ctagaacagg ataattgcct gtgtttaggc agataggcct aaatctttca gattctttct   4800

acaaggcaaa taacccctct cttgttaatt atgatgctga gaaagcctct gtctctttat   4860

ttcaccttgc caagacaccc acactacttt ggtgatgaaa agaaaggaat gagagggaaa   4920

gtttggacct gtcactttgg tgacagggaa agtccaggtc actttattct gtaactctcc   4980

attcactggt caaataactc catgaggcta tcagtggcta cagtggaagg acctgatctt   5040

gtccatcttt gtgtgcacag agcctagcac agggcttggt agagggtata tctagtgaat   5100

ggagaataca tggagaaact taactaagtt acacaagcat atctgacagg aatgttacct   5160

tcaattgtat gttacatatg attagtcact tttcatacac tataacctct gatttttcac   5220

tcaagtttgg gctgattata ttgtaatgat gttagataat actcaacatg attcagtatg   5280

acaaactttt ttgagcacct actttatata aaacatgaca aattgcagtg tgatgtaatc   5340

aaaaacaaag aagccctata agaccatttc tctagaacag atgttcttaa tatttttctt   5400

actctaaaat atgtggtaga tagtatgcaa gaaaagccgg gtgcggtggc tcaggcctgt   5460

aatcccagca ctttgggagg ccaagatggg cggatcatga agtcaggagt tcgagaccag   5520

cctgaccaac atggtgaaac cccgtctcta ct                                 5552


<210>  8697
<211>  1278
<212>  PRT
<213>  Homosapiens

<400>  8697

Met Lys His Leu Tyr Gly Leu Phe His Tyr Asn Pro Met Met Leu Gly 
1               5                   10                  15      


Leu Glu Ser Leu Pro Asp Pro Thr Asp Thr Trp Glu Ile Ile Glu Thr 
            20                  25                  30          


Ile Gly Lys Gly Thr Tyr Gly Lys Val Tyr Lys Val Thr Asn Lys Arg 
        35                  40                  45              


Asp Gly Ser Leu Ala Ala Val Lys Ile Leu Asp Pro Val Ser Asp Met 
    50                  55                  60                  


Asp Glu Glu Ile Glu Ala Glu Tyr Asn Ile Leu Gln Phe Leu Pro Asn 
65                  70                  75                  80  


His Pro Asn Val Val Lys Phe Tyr Gly Met Phe Tyr Lys Ala Asp His 
                85                  90                  95      


Cys Val Gly Gly Gln Leu Trp Leu Val Leu Glu Leu Cys Asn Gly Gly 
            100                 105                 110         


Ser Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys Gly Gln Arg Leu 
        115                 120                 125             


Asp Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala Leu Leu Gly Leu 
    130                 135                 140                 


Gln His Leu His Asn Asn Arg Ile Ile His Arg Asp Val Lys Gly Asn 
145                 150                 155                 160 


Asn Ile Leu Leu Thr Thr Glu Gly Gly Val Lys Leu Val Asp Phe Gly 
                165                 170                 175     


Val Ser Ala Gln Leu Thr Ser Thr Arg Leu Arg Arg Asn Thr Ser Val 
            180                 185                 190         


Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Ala Cys Glu Gln Gln 
        195                 200                 205             


Tyr Asp Ser Ser Tyr Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile 
    210                 215                 220                 


Thr Ala Ile Glu Leu Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His 
225                 230                 235                 240 


Pro Val Lys Thr Leu Phe Lys Ile Pro Arg Asn Pro Pro Pro Thr Leu 
                245                 250                 255     


Leu His Pro Glu Lys Trp Cys Glu Glu Phe Asn His Phe Ile Ser Gln 
            260                 265                 270         


Cys Leu Ile Lys Asp Phe Glu Arg Arg Pro Ser Val Thr His Leu Leu 
        275                 280                 285             


Asp His Pro Phe Ile Lys Gly Val His Gly Lys Val Leu Phe Leu Gln 
    290                 295                 300                 


Lys Gln Leu Ala Lys Val Leu Gln Asp Gln Lys His Gln Asn Pro Val 
305                 310                 315                 320 


Ala Lys Thr Arg His Glu Arg Met His Thr Arg Arg Pro Tyr His Val 
                325                 330                 335     


Glu Asp Ala Glu Lys Tyr Cys Leu Glu Asp Asp Leu Val Asn Leu Glu 
            340                 345                 350         


Val Leu Asp Glu Asp Thr Ile Ile His Gln Leu Gln Lys Arg Tyr Ala 
        355                 360                 365             


Asp Leu Leu Ile Tyr Thr Tyr Val Gly Asp Ile Leu Ile Ala Leu Asn 
    370                 375                 380                 


Pro Phe Gln Asn Leu Ser Ile Tyr Ser Pro Gln Phe Ser Arg Leu Tyr 
385                 390                 395                 400 


His Gly Val Lys Arg Ala Ser Asn Pro Pro His Ile Phe Ala Ser Ala 
                405                 410                 415     


Asp Ala Ala Tyr Gln Cys Met Val Thr Leu Ser Lys Asp Gln Cys Ile 
            420                 425                 430         


Val Ile Ser Gly Glu Ser Gly Ser Gly Lys Thr Glu Ser Ala His Leu 
        435                 440                 445             


Ile Val Gln His Leu Thr Phe Leu Gly Lys Ala Asn Asn Gln Thr Leu 
    450                 455                 460                 


Arg Glu Lys Ile Leu Gln Val Asn Ser Leu Val Glu Ala Phe Gly Asn 
465                 470                 475                 480 


Ser Cys Thr Ala Ile Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Leu 
                485                 490                 495     


Glu Met Met Phe Thr Pro Thr Gly Val Val Met Gly Ala Arg Ile Ser 
            500                 505                 510         


Glu Tyr Leu Leu Glu Lys Ser Arg Val Ile Lys Gln Ala Ala Arg Glu 
        515                 520                 525             


Lys Asn Phe His Ile Phe Tyr Tyr Ile Tyr Ala Gly Leu His His Gln 
    530                 535                 540                 


Lys Lys Leu Ser Asp Phe Arg Leu Pro Glu Glu Lys Pro Pro Arg Tyr 
545                 550                 555                 560 


Ile Ala Asp Glu Thr Gly Arg Val Met His Asp Ile Thr Ser Lys Glu 
                565                 570                 575     


Ser Tyr Arg Arg Gln Phe Glu Ala Ile Gln His Cys Phe Arg Ile Ile 
            580                 585                 590         


Gly Phe Thr Asp Lys Glu Val His Ser Val Tyr Arg Ile Leu Ala Gly 
        595                 600                 605             


Ile Leu Asn Ile Gly Asn Ile Glu Phe Ala Ala Ile Ser Ser Gln His 
    610                 615                 620                 


Gln Thr Asp Lys Ser Glu Val Pro Asn Ala Glu Ala Leu Gln Asn Ala 
625                 630                 635                 640 


Ala Ser Val Leu Cys Ile Ser Pro Glu Glu Leu Gln Glu Ala Leu Thr 
                645                 650                 655     


Ser His Cys Val Val Thr Arg Gly Glu Thr Ile Ile Arg Ala Asn Thr 
            660                 665                 670         


Val Asp Arg Ala Ala Asp Val Arg Asp Ala Met Ser Lys Ala Leu Tyr 
        675                 680                 685             


Gly Arg Leu Phe Ser Trp Ile Val Asn Arg Ile Asn Thr Leu Leu Gln 
    690                 695                 700                 


Pro Asp Glu Asn Ile Cys Ser Ala Gly Gly Gly Met Asn Val Gly Ile 
705                 710                 715                 720 


Leu Asp Ile Phe Gly Phe Glu Asn Phe Gln Arg Asn Ser Phe Glu Gln 
                725                 730                 735     


Leu Cys Ile Asn Ile Ala Asn Glu Gln Ile Gln Tyr Tyr Phe Asn Gln 
            740                 745                 750         


His Val Phe Ala Leu Glu Gln Met Glu Tyr Gln Asn Glu Gly Ile Asp 
        755                 760                 765             


Ala Val Pro Val Glu Tyr Glu Asp Asn Arg Pro Leu Leu Asp Met Phe 
    770                 775                 780                 


Leu Gln Lys Pro Leu Gly Leu Leu Ala Leu Leu Asp Glu Glu Ser Arg 
785                 790                 795                 800 


Phe Pro Gln Ala Thr Asp Gln Thr Leu Val Asp Lys Phe Glu Asp Asn 
                805                 810                 815     


Leu Arg Cys Lys Tyr Phe Trp Arg Pro Lys Gly Val Glu Leu Cys Phe 
            820                 825                 830         


Gly Ile Gln His Tyr Ala Gly Lys Val Leu Tyr Asp Ala Ser Gly Val 
        835                 840                 845             


Leu Glu Lys Asn Arg Asp Thr Leu Pro Ala Asp Val Val Val Val Leu 
    850                 855                 860                 


Arg Thr Ser Glu Asn Lys Leu Leu Gln Gln Leu Phe Ser Ile Pro Leu 
865                 870                 875                 880 


Thr Lys Thr Gly Asn Leu Ala Gln Thr Arg Ala Arg Ile Thr Val Ala 
                885                 890                 895     


Ser Ser Ser Leu Pro Pro His Phe Ser Ala Gly Lys Ala Lys Val Asp 
            900                 905                 910         


Thr Leu Glu Val Ile Arg His Pro Glu Glu Thr Thr Asn Met Lys Arg 
        915                 920                 925             


Gln Thr Val Ala Ser Tyr Phe Arg Tyr Ser Leu Met Asp Leu Leu Ser 
    930                 935                 940                 


Lys Met Val Val Gly Gln Pro His Phe Val Arg Cys Ile Lys Pro Asn 
945                 950                 955                 960 


Asp Asp Arg Glu Ala Leu Gln Phe Ser Arg Glu Arg Val Leu Ala Gln 
                965                 970                 975     


Leu Arg Ser Thr Gly Ile Leu Glu Thr Val Ser Ile Arg Arg Gln Gly 
            980                 985                 990         


Tyr Ser His Arg Ile Leu Phe Glu  Glu Phe Val Lys Arg  Tyr Tyr Tyr 
        995                 1000                 1005             


Leu Ala  Phe Thr Ala His Gln  Thr Pro Leu Ala Ser  Lys Glu Ser 
    1010                 1015                 1020             


Cys Val  Ala Ile Leu Glu Lys  Ser Arg Leu Asp His  Trp Val Leu 
    1025                 1030                 1035             


Gly Lys  Thr Lys Val Phe Leu  Lys Tyr Tyr His Val  Glu Gln Leu 
    1040                 1045                 1050             


Asn Leu  Leu Leu Arg Glu Val  Ile Gly Arg Val Val  Val Leu Gln 
    1055                 1060                 1065             


Ala Tyr  Thr Lys Gly Trp Leu  Gly Ala Arg Arg Tyr  Lys Arg Val 
    1070                 1075                 1080             


Arg Glu  Lys Arg Glu Lys Gly  Ala Ile Ala Ile Gln  Ser Ala Trp 
    1085                 1090                 1095             


Arg Gly  Tyr Asp Ala Arg Arg  Lys Phe Lys Lys Ile  Ser Asn Arg 
    1100                 1105                 1110             


Arg Asn  Glu Ser Ala Ala His  Asn Gln Ala Gly Asp  Thr Ser Asn 
    1115                 1120                 1125             


Gln Ser  Ser Gly Pro His Ser  Pro Val Ala Ala Gly  Thr Arg Gly 
    1130                 1135                 1140             


Ser Ala  Glu Val Gln Asp Cys  Ser Glu Pro Gly Asp  His Lys Val 
    1145                 1150                 1155             


Leu Arg  Gly Ser Val His Arg  Arg Ser His Ser Gln  Ala Glu Ser 
    1160                 1165                 1170             


Asn Asn  Gly Arg Thr Gln Thr  Ser Ser Asn Ser Pro  Ala Val Thr 
    1175                 1180                 1185             


Glu Lys  Asn Gly His Ser Gln  Ala Gln Ser Ser Pro  Lys Gly Cys 
    1190                 1195                 1200             


Asp Ile  Phe Ala Gly His Ala  Asn Lys His Ser Val  Ser Gly Thr 
    1205                 1210                 1215             


Asp Leu  Leu Ser Ser Arg Ile  Cys His Pro Ala Pro  Asp Gln Gln 
    1220                 1225                 1230             


Gly Leu  Ser Leu Trp Gly Ala  Pro Gln Lys Pro Ala  Phe Pro His 
    1235                 1240                 1245             


Tyr Gly  Cys Asn Phe Tyr Gly  Phe Arg Lys Trp Ser  Cys Thr Glu 
    1250                 1255                 1260             


Ala Ser  Asn Thr Ser Pro Thr  Met Ser Ala Ala Gln  Asn Ala Glu 
    1265                 1270                 1275             


<210>  8698
<211>  5471
<212>  DNA
<213>  Homosapiens

<400>  8698
ctagatcgaa agtcctttgg taatgatgtg tcatacattc tagtcatcaa agacaccatt     60

ttctgggcct gaagtgttct gctggttttt ggaggaatga gaatccaatc tctcataagc    120

cggattcaga aaataggtca tcgatgaaac atctgtatgg attatttcac tataatccta    180

tgatgcttgg acttgaatca cttccagatc ccacagacac ctgggaaatt atagagacca    240

ttggtaaagg cacctatggc aaagtctaca aggtaactaa caagagagat gggagcctgg    300

ctgcagtgaa aattctggat ccagtcagtg atatggatga agaaattgag gcagaataca    360

acattttgca gttccttcct aatcatccca atgttgtaaa gttttatggg atgttttaca    420

aagcggatca ctgtgtaggg ggacagctgt ggctggtcct ggagctgtgt aatgggggct    480

cagtcactga gcttgtcaaa ggtctactca gatgtggcca gcggttggat gaagcaatga    540

tctcatacat cttgtacggg gccctcttgg gccttcagca tttgcacaac aaccgaatca    600

tccaccgtga tgtgaagggg aataacattc ttctgacaac agaaggagga gttaagctcg    660

ttgactttgg tgtttcagct caactcacca gtacacgtct gcggagaaac acatctgttg    720

gcaccccgtt ctggatggcc cctgaggtca ttgcctgtga gcagcagtat gactcttcct    780

atgacgctcg ctgtgacgtc tggtccttgg ggatcacagc tattgaactg ggggatggag    840

accctcccct ctttgacatg catcctgtga aaacactctt taagattcca agaaatcctc    900

cacctacttt acttcatcca gaaaaatggt gtgaagaatt caaccacttt atttcacagt    960

gtcttattaa ggattttgaa aggcgacctt ccgtcacaca tctccttgac cacccattta   1020

ttaaaggagt acatggaaaa gttctgtttc tgcaaaaaca gctggccaag gttctccaag   1080

accagaagca tcaaaatcct gttgctaaaa ccaggcatga gaggatgcat accagaagac   1140

cttatcatgt ggaagatgct gaaaaatact gccttgagga tgatttggtc aacctagagg   1200

ttctggatga ggatacaatt atccatcagt tgcagaaacg ttatgcagac ttgctaattt   1260

acacatatgt tggagacatc ttaattgcct taaacccctt ccagaatcta agcatatact   1320

ctccacagtt ttccagactt tatcatgggg tgaaacgcgc ctccaatccc ccccacatat   1380

ttgcatcagc agatgctgct taccagtgca tggttactct cagcaaagac cagtgcattg   1440

tcatcagcgg agagagtggc tctgggaaga cagaaagcgc ccacctgatt gttcagcatt   1500

tgactttctt gggaaaggcc aataatcaga ccttgagaga gaaaattcta caagtcaact   1560

ccctggtgga agcctttggg aactcatgca ctgccatcaa tgacaactcg agccgttttg   1620

gaaaatatct ggaaatgatg tttacaccaa ctggagttgt gatgggggca agaatctctg   1680

aatatctcct ggaaaaatcc agagttataa aacaggcagc gagagagaaa aattttcata   1740

tattttacta tatttatgct ggtcttcatc accaaaagaa gctttctgat ttcagacttc   1800

ctgaggaaaa acctcctagg tacatagctg atgaaactgg aagggtgatg cacgacataa   1860

cttccaagga gtcttacaga agacaattcg aagcaattca gcattgcttc aggattatag   1920

ggttcacgga caaagaggtg cactcagtgt acagaatttt ggctgggatt ttgaatattg   1980

ggaacattga gttcgcagct atttcctctc aacatcagac tgataaaagt gaggtgccca   2040

atgctgaagc tttgcaaaat gctgcctctg ttctgtgcat tagccctgaa gagctccagg   2100

aggccctcac ctcccactgt gtggtcaccc ggggcgagac catcatccgt gccaacactg   2160

tagacagggc tgcggacgtt cgagacgcca tgtccaaagc cctgtatggg aggctcttca   2220

gctggattgt gaatcgcatt aatacactcc tgcagccaga cgaaaacata tgtagtgcag   2280

gaggtggaat gaatgtgggg atcttggata tctttggatt cgagaatttt cagagaaatt   2340

catttgagca gctctgcata aacatcgcca atgagcaaat ccagtactat ttcaatcagc   2400

atgtttttgc tcttgagcag atggaatatc agaatgaagg cattgatgct gtacccgtgg   2460

aatatgagga caaccgcccg ctcttggaca tgttcctcca gaaacccctg ggactgcttg   2520

cacttttgga tgaggaaagt cggtttcccc aagcaactga ccagaccctg gttgataaat   2580

ttgaagataa tctacgatgc aaatacttct ggaggcccaa aggagtggaa ctgtgctttg   2640

gcattcagca ttatgctgga aaggtattat atgatgcttc tggggttctt gagaaaaata   2700

gagacactct ccctgccgat gtggttgtgg tcctgagaac gtcagaaaac aagcttcttc   2760

agcagctctt ctcaatccct ctgaccaaaa caggtaattt ggcccagaca agagctagga   2820

taacagtggc ctcaagttct ttgcctccac atttcagtgc tgggaaagcc aaggtggaca   2880

ctctggaggt gatacggcat ccggaagaaa ccaccaacat gaagaggcaa actgtggctt   2940

cttacttccg gtattctctg atggacctgc tctccaaaat ggtggttgga cagccccact   3000

ttgtgcgctg cattaaaccc aatgatgacc gagaggccct gcagttctct cgagagaggg   3060

tgctggccca gctccgctcc acagggattc tggagacagt cagcatccgc cgccagggct   3120

attcccaccg catccttttt gaagaatttg tgaaaaggta ttattacttg gcattcacag   3180

cacatcaaac acctcttgct agcaaagaga gctgtgtggc tatcttggaa aagtccagat   3240

tagatcactg ggtactggga aaaacaaagg tttttctcaa atattaccat gttgagcaat   3300

taaatttgct gcttcgagaa gtcataggca gagtggttgt gctgcaggca tataccaagg   3360

ggtggcttgg agccaggaga tacaaaaggg tcagagagaa gagagagaag ggagccattg   3420

ccatccagtc aggggacact tcaaaccaaa gcagtgggcc acattccccc gtcgcagcag   3480

gtacgagggg aagtgccgag gttcaagact gcagcgagcc tggtgaccat aaagttctca   3540

ggggctctgt acatcgtagg agccattcac aagcagaatc caacaatggc cgtacacaga   3600

cttcaagcaa ctctcctgct gtcacagaga aaaatgggca ttcacaagcc cagagttctc   3660

caaaagggtg cgatatcttc gcaggacatg caaacaagca ctcggtttct gggactgatt   3720

tgctgtcttc tcggatatgc catcctgctc cagatcagca aggattgagt ctctggggag   3780

cccctcaaaa gcctgccttt ccacattacg gatgtaactt ttatgggttc agaaaatggt   3840

cttgcacaga agcatcgaac acctcgccga cgatgtcagc agcccaaaat gctgagtagc   3900

cctgaggaca ccatgtacta taaccagtta aatggaactc tagaatatca agggagcaag   3960

aggaagccaa gaaaacttgg ccaaatcaaa gtacttgatg gggaagatga atattacaaa   4020

tctctgtcac cagtggactg tatccctgag gagaacaact cagcccaccc ttcctttttt   4080

tcttcatcct caaaaggaga ctcttttgct caacattaaa ttgtgcttcc taaccctaaa   4140

tctgtccaga gtaggaacat tcatggtaat cgactgtctg tcattgcgta agaaagcact   4200

gatatggggt cagcttcttt ggacatatgg tccatgcctg aaccttactg aaccacttgc   4260

agattccaaa acatcttatc ctatcctcta ccactctccc acatgtgttg tgcagcctga   4320

gctgggcgct gccttccttt ctcatcccat ggggccctgt gggacactga gaacaccttt   4380

acaatagttt aaacagtcat tcatgccccc agtgtctagg aagataacag ccagtctcac   4440

cccagtctaa tcatggaccc tgataatatt gcttgatttt tcctatcaag ttacttttca   4500

atccattcag aatctgcccc agtggagacc caggagttcc tttcctgcac tcttctccat   4560

cctcccacct ttgctgggct tttctatcac tcccacctcc cccagagtca gggctccatt   4620

gctgagtgcc ccatcctgga ggattggccc caagatctcc tagaacagga taattgcctg   4680

tgtttaggca gataggccta aatctttcag attctttcta caaggcaaat aacccctctc   4740

ttgttaatta tgatgctgag aaagcctctg tctctttatt tcaccttgcc aagacaccca   4800

cactactttg gtgatgaaaa gaaaggaatg agagggaaag tttggacctg tcactttggt   4860

gacagggaaa gtccaggtca ctttattctg taactctcca ttcactggtc aaataactcc   4920

atgaggctat cagtggctac agtggaagga cctgatcttg tccatctttg tgtgcacaga   4980

gcctagcaca gggcttggta gagggtatat ctagtgaatg gagaatacat ggagaaactt   5040

aactaagtta cacaagcata tctgacagga atgttacctt caattgtatg ttacatatga   5100

ttagtcactt ttcatacact ataacctctg atttttcact caagtttggg ctgattatat   5160

tgtaatgatg ttagataata ctcaacatga ttcagtatga caaacttttt tgagcaccta   5220

ctttatataa aacatgacaa attgcagtgt gatgtaatca aaaacaaaga agccctataa   5280

gaccatttct ctagaacaga tgttcttaat atttttctta ctctaaaata tgtggtagat   5340

agtatgcaag aaaagccggg tgcggtggct caggcctgta atcccagcac tttgggaggc   5400

caagatgggc ggatcatgaa gtcaggagtt cgagaccagc ctgaccaaca tggtgaaacc   5460

ccgtctctac t                                                        5471


<210>  8699
<211>  1251
<212>  PRT
<213>  Homosapiens

<400>  8699

Met Lys His Leu Tyr Gly Leu Phe His Tyr Asn Pro Met Met Leu Gly 
1               5                   10                  15      


Leu Glu Ser Leu Pro Asp Pro Thr Asp Thr Trp Glu Ile Ile Glu Thr 
            20                  25                  30          


Ile Gly Lys Gly Thr Tyr Gly Lys Val Tyr Lys Val Thr Asn Lys Arg 
        35                  40                  45              


Asp Gly Ser Leu Ala Ala Val Lys Ile Leu Asp Pro Val Ser Asp Met 
    50                  55                  60                  


Asp Glu Glu Ile Glu Ala Glu Tyr Asn Ile Leu Gln Phe Leu Pro Asn 
65                  70                  75                  80  


His Pro Asn Val Val Lys Phe Tyr Gly Met Phe Tyr Lys Ala Asp His 
                85                  90                  95      


Cys Val Gly Gly Gln Leu Trp Leu Val Leu Glu Leu Cys Asn Gly Gly 
            100                 105                 110         


Ser Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys Gly Gln Arg Leu 
        115                 120                 125             


Asp Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala Leu Leu Gly Leu 
    130                 135                 140                 


Gln His Leu His Asn Asn Arg Ile Ile His Arg Asp Val Lys Gly Asn 
145                 150                 155                 160 


Asn Ile Leu Leu Thr Thr Glu Gly Gly Val Lys Leu Val Asp Phe Gly 
                165                 170                 175     


Val Ser Ala Gln Leu Thr Ser Thr Arg Leu Arg Arg Asn Thr Ser Val 
            180                 185                 190         


Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Ala Cys Glu Gln Gln 
        195                 200                 205             


Tyr Asp Ser Ser Tyr Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile 
    210                 215                 220                 


Thr Ala Ile Glu Leu Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His 
225                 230                 235                 240 


Pro Val Lys Thr Leu Phe Lys Ile Pro Arg Asn Pro Pro Pro Thr Leu 
                245                 250                 255     


Leu His Pro Glu Lys Trp Cys Glu Glu Phe Asn His Phe Ile Ser Gln 
            260                 265                 270         


Cys Leu Ile Lys Asp Phe Glu Arg Arg Pro Ser Val Thr His Leu Leu 
        275                 280                 285             


Asp His Pro Phe Ile Lys Gly Val His Gly Lys Val Leu Phe Leu Gln 
    290                 295                 300                 


Lys Gln Leu Ala Lys Val Leu Gln Asp Gln Lys His Gln Asn Pro Val 
305                 310                 315                 320 


Ala Lys Thr Arg His Glu Arg Met His Thr Arg Arg Pro Tyr His Val 
                325                 330                 335     


Glu Asp Ala Glu Lys Tyr Cys Leu Glu Asp Asp Leu Val Asn Leu Glu 
            340                 345                 350         


Val Leu Asp Glu Asp Thr Ile Ile His Gln Leu Gln Lys Arg Tyr Ala 
        355                 360                 365             


Asp Leu Leu Ile Tyr Thr Tyr Val Gly Asp Ile Leu Ile Ala Leu Asn 
    370                 375                 380                 


Pro Phe Gln Asn Leu Ser Ile Tyr Ser Pro Gln Phe Ser Arg Leu Tyr 
385                 390                 395                 400 


His Gly Val Lys Arg Ala Ser Asn Pro Pro His Ile Phe Ala Ser Ala 
                405                 410                 415     


Asp Ala Ala Tyr Gln Cys Met Val Thr Leu Ser Lys Asp Gln Cys Ile 
            420                 425                 430         


Val Ile Ser Gly Glu Ser Gly Ser Gly Lys Thr Glu Ser Ala His Leu 
        435                 440                 445             


Ile Val Gln His Leu Thr Phe Leu Gly Lys Ala Asn Asn Gln Thr Leu 
    450                 455                 460                 


Arg Glu Lys Ile Leu Gln Val Asn Ser Leu Val Glu Ala Phe Gly Asn 
465                 470                 475                 480 


Ser Cys Thr Ala Ile Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Leu 
                485                 490                 495     


Glu Met Met Phe Thr Pro Thr Gly Val Val Met Gly Ala Arg Ile Ser 
            500                 505                 510         


Glu Tyr Leu Leu Glu Lys Ser Arg Val Ile Lys Gln Ala Ala Arg Glu 
        515                 520                 525             


Lys Asn Phe His Ile Phe Tyr Tyr Ile Tyr Ala Gly Leu His His Gln 
    530                 535                 540                 


Lys Lys Leu Ser Asp Phe Arg Leu Pro Glu Glu Lys Pro Pro Arg Tyr 
545                 550                 555                 560 


Ile Ala Asp Glu Thr Gly Arg Val Met His Asp Ile Thr Ser Lys Glu 
                565                 570                 575     


Ser Tyr Arg Arg Gln Phe Glu Ala Ile Gln His Cys Phe Arg Ile Ile 
            580                 585                 590         


Gly Phe Thr Asp Lys Glu Val His Ser Val Tyr Arg Ile Leu Ala Gly 
        595                 600                 605             


Ile Leu Asn Ile Gly Asn Ile Glu Phe Ala Ala Ile Ser Ser Gln His 
    610                 615                 620                 


Gln Thr Asp Lys Ser Glu Val Pro Asn Ala Glu Ala Leu Gln Asn Ala 
625                 630                 635                 640 


Ala Ser Val Leu Cys Ile Ser Pro Glu Glu Leu Gln Glu Ala Leu Thr 
                645                 650                 655     


Ser His Cys Val Val Thr Arg Gly Glu Thr Ile Ile Arg Ala Asn Thr 
            660                 665                 670         


Val Asp Arg Ala Ala Asp Val Arg Asp Ala Met Ser Lys Ala Leu Tyr 
        675                 680                 685             


Gly Arg Leu Phe Ser Trp Ile Val Asn Arg Ile Asn Thr Leu Leu Gln 
    690                 695                 700                 


Pro Asp Glu Asn Ile Cys Ser Ala Gly Gly Gly Met Asn Val Gly Ile 
705                 710                 715                 720 


Leu Asp Ile Phe Gly Phe Glu Asn Phe Gln Arg Asn Ser Phe Glu Gln 
                725                 730                 735     


Leu Cys Ile Asn Ile Ala Asn Glu Gln Ile Gln Tyr Tyr Phe Asn Gln 
            740                 745                 750         


His Val Phe Ala Leu Glu Gln Met Glu Tyr Gln Asn Glu Gly Ile Asp 
        755                 760                 765             


Ala Val Pro Val Glu Tyr Glu Asp Asn Arg Pro Leu Leu Asp Met Phe 
    770                 775                 780                 


Leu Gln Lys Pro Leu Gly Leu Leu Ala Leu Leu Asp Glu Glu Ser Arg 
785                 790                 795                 800 


Phe Pro Gln Ala Thr Asp Gln Thr Leu Val Asp Lys Phe Glu Asp Asn 
                805                 810                 815     


Leu Arg Cys Lys Tyr Phe Trp Arg Pro Lys Gly Val Glu Leu Cys Phe 
            820                 825                 830         


Gly Ile Gln His Tyr Ala Gly Lys Val Leu Tyr Asp Ala Ser Gly Val 
        835                 840                 845             


Leu Glu Lys Asn Arg Asp Thr Leu Pro Ala Asp Val Val Val Val Leu 
    850                 855                 860                 


Arg Thr Ser Glu Asn Lys Leu Leu Gln Gln Leu Phe Ser Ile Pro Leu 
865                 870                 875                 880 


Thr Lys Thr Gly Asn Leu Ala Gln Thr Arg Ala Arg Ile Thr Val Ala 
                885                 890                 895     


Ser Ser Ser Leu Pro Pro His Phe Ser Ala Gly Lys Ala Lys Val Asp 
            900                 905                 910         


Thr Leu Glu Val Ile Arg His Pro Glu Glu Thr Thr Asn Met Lys Arg 
        915                 920                 925             


Gln Thr Val Ala Ser Tyr Phe Arg Tyr Ser Leu Met Asp Leu Leu Ser 
    930                 935                 940                 


Lys Met Val Val Gly Gln Pro His Phe Val Arg Cys Ile Lys Pro Asn 
945                 950                 955                 960 


Asp Asp Arg Glu Ala Leu Gln Phe Ser Arg Glu Arg Val Leu Ala Gln 
                965                 970                 975     


Leu Arg Ser Thr Gly Ile Leu Glu Thr Val Ser Ile Arg Arg Gln Gly 
            980                 985                 990         


Tyr Ser His Arg Ile Leu Phe Glu  Glu Phe Val Lys Arg  Tyr Tyr Tyr 
        995                 1000                 1005             


Leu Ala  Phe Thr Ala His Gln  Thr Pro Leu Ala Ser  Lys Glu Ser 
    1010                 1015                 1020             


Cys Val  Ala Ile Leu Glu Lys  Ser Arg Leu Asp His  Trp Val Leu 
    1025                 1030                 1035             


Gly Lys  Thr Lys Val Phe Leu  Lys Tyr Tyr His Val  Glu Gln Leu 
    1040                 1045                 1050             


Asn Leu  Leu Leu Arg Glu Val  Ile Gly Arg Val Val  Val Leu Gln 
    1055                 1060                 1065             


Ala Tyr  Thr Lys Gly Trp Leu  Gly Ala Arg Arg Tyr  Lys Arg Val 
    1070                 1075                 1080             


Arg Glu  Lys Arg Glu Lys Gly  Ala Ile Ala Ile Gln  Ser Gly Asp 
    1085                 1090                 1095             


Thr Ser  Asn Gln Ser Ser Gly  Pro His Ser Pro Val  Ala Ala Gly 
    1100                 1105                 1110             


Thr Arg  Gly Ser Ala Glu Val  Gln Asp Cys Ser Glu  Pro Gly Asp 
    1115                 1120                 1125             


His Lys  Val Leu Arg Gly Ser  Val His Arg Arg Ser  His Ser Gln 
    1130                 1135                 1140             


Ala Glu  Ser Asn Asn Gly Arg  Thr Gln Thr Ser Ser  Asn Ser Pro 
    1145                 1150                 1155             


Ala Val  Thr Glu Lys Asn Gly  His Ser Gln Ala Gln  Ser Ser Pro 
    1160                 1165                 1170             


Lys Gly  Cys Asp Ile Phe Ala  Gly His Ala Asn Lys  His Ser Val 
    1175                 1180                 1185             


Ser Gly  Thr Asp Leu Leu Ser  Ser Arg Ile Cys His  Pro Ala Pro 
    1190                 1195                 1200             


Asp Gln  Gln Gly Leu Ser Leu  Trp Gly Ala Pro Gln  Lys Pro Ala 
    1205                 1210                 1215             


Phe Pro  His Tyr Gly Cys Asn  Phe Tyr Gly Phe Arg  Lys Trp Ser 
    1220                 1225                 1230             


Cys Thr  Glu Ala Ser Asn Thr  Ser Pro Thr Met Ser  Ala Ala Gln 
    1235                 1240                 1245             


Asn Ala  Glu 
    1250     


<210>  8700
<211>  5521
<212>  DNA
<213>  Homosapiens

<400>  8700
ctagatcgaa agtcctttgg taatgatgtg tcatacattc tagtcatcaa agacaccatt     60

ttctgggcct gaagtgttct gctggttttt ggaggaatga gaatccaatc tctcataagc    120

cggattcaga aaataggtca tcgatgaaac atctgtatgg attatttcac tataatccta    180

tgatgcttgg acttgaatca cttccagatc ccacagacac ctgggaaatt atagagacca    240

ttggtaaagg cacctatggc aaagtctaca aggtaactaa caagagagat gggagcctgg    300

ctgcagtgaa aattctggat ccagtcagtg atatggatga agaaattgag gcagaataca    360

acattttgca gttccttcct aatcatccca atgttgtaaa gttttatggg atgttttaca    420

aagcggatca ctgtgtaggg ggacagctgt ggctggtcct ggagctgtgt aatgggggct    480

cagtcactga gcttgtcaaa ggtctactca gatgtggcca gcggttggat gaagcaatga    540

tctcatacat cttgtacggg gccctcttgg gccttcagca tttgcacaac aaccgaatca    600

tccaccgtga tgtgaagggg aataacattc ttctgacaac agaaggagga gttaagctcg    660

ttgactttgg tgtttcagct caactcacca gtacacgtct gcggagaaac acatctgttg    720

gcaccccgtt ctggatggcc cctgaggtca ttgcctgtga gcagcagtat gactcttcct    780

atgacgctcg ctgtgacgtc tggtccttgg ggatcacagc tattgaactg ggggatggag    840

accctcccct ctttgacatg catcctgtga aaacactctt taagattcca agaaatcctc    900

cacctacttt acttcatcca gaaaaatggt gtgaagaatt caaccacttt atttcacagt    960

gtcttattaa ggattttgaa aggcgacctt ccgtcacaca tctccttgac cacccattta   1020

ttaaaggagt acatggaaaa gttctgtttc tgcaaaaaca gctggccaag gttctccaag   1080

accagaagca tcaaaatcct gttgctaaaa ccaggcatga gaggatgcat accagaagac   1140

cttatcatgt ggaagatgct gaaaaatact gccttgagga tgatttggtc aacctagagg   1200

ttctggatga ggatacaatt atccatcagt tgcagaaacg ttatgcagac ttgctaattt   1260

acacatatgt tggagacatc ttaattgcct taaacccctt ccagaatcta agcatatact   1320

ctccacagtt ttccagactt tatcatgggg tgaaacgcgc ctccaatccc ccccacatat   1380

ttgcatcagc agatgctgct taccagtgca tggttactct cagcaaagac cagtgcattg   1440

tcatcagcgg agagagtggc tctgggaaga cagaaagcgc ccacctgatt gttcagcatt   1500

tgactttctt gggaaaggcc aataatcaga ccttgagaga gaaaattcta caagtcaact   1560

ccctggtgga agcctttggg aactcatgca ctgccatcaa tgacaactcg agccgttttg   1620

gaaaatatct ggaaatgatg tttacaccaa ctggagttgt gatgggggca agaatctctg   1680

aatatctcct ggaaaaatcc agagttataa aacaggcagc gagagagaaa aattttcata   1740

tattttacta tatttatgct ggtcttcatc accaaaagaa gctttctgat ttcagacttc   1800

ctgaggaaaa acctcctagg tacatagctg atgaaactgg aagggtgatg cacgacataa   1860

cttccaagga gtcttacaga agacaattcg aagcaattca gcattgcttc aggattatag   1920

ggttcacgga caaagaggtg cactcagtgt acagaatttt ggctgggatt ttgaatattg   1980

ggaacattga gttcgcagct atttcctctc aacatcagac tgataaaagt gaggtgccca   2040

atgctgaagc tttgcaaaat gctgcctctg ttctgtgcat tagccctgaa gagctccagg   2100

aggccctcac ctcccactgt gtggtcaccc ggggcgagac catcatccgt gccaacactg   2160

tagacagggc tgcggacgtt cgagacgcca tgtccaaagc cctgtatggg aggctcttca   2220

gctggattgt gaatcgcatt aatacactcc tgcagccaga cgaaaacata tgtagtgcag   2280

gaggtggaat gaatgtgggg atcttggata tctttggatt cgagaatttt cagagaaatt   2340

catttgagca gctctgcata aacatcgcca atgagcaaat ccagtactat ttcaatcagc   2400

atgtttttgc tcttgagcag atggaatatc agaatgaagg cattgatgct gtacccgtgg   2460

aatatgagga caaccgcccg ctcttggaca tgttcctcca gaaacccctg ggactgcttg   2520

cacttttgga tgaggaaagt cggtttcccc aagcaactga ccagaccctg gttgataaat   2580

ttgaagataa tctacgatgc aaatacttct ggaggcccaa aggagtggaa ctgtgctttg   2640

gcattcagca ttatgctgga aaggtattat atgatgcttc tggggttctt gagaaaaata   2700

gagacactct ccctgccgat gtggttgtgg tcctgagaac gtcagaaaac aagcttcttc   2760

agcagctctt ctcaatccct ctgaccaaaa caggtaattt ggcccagaca agagctagga   2820

taacagtggc ctcaagttct ttgcctccac atttcagtgc tgggaaagcc aaggtggaca   2880

ctctggaggt gatacggcat ccggaagaaa ccaccaacat gaagaggcaa actgtggctt   2940

cttacttccg gtattctctg atggacctgc tctccaaaat ggtggttgga cagccccact   3000

ttgtgcgctg cattaaaccc aatgatgacc gagaggccct gcagttctct cgagagaggg   3060

tgctggccca gctccgctcc acagggattc tggagacagt cagcatccgc cgccagggct   3120

attcccaccg catccttttt gaagaatttg tgaaaaggta ttattacttg gcattcacag   3180

cacatcaaac acctcttgct agcaaagaga gctgtgtggc tatcttggaa aagtccagat   3240

tagatcactg ggtactggga aaaacaaagg tttttctcaa atattaccat gttgagcaat   3300

taaatttgct gcttcgagaa gtcataggca gagtggttgt gctgcaggca tataccaagg   3360

ggtggcttgg agccaggaga tacaaaaggg tcagagagaa gagagagaag ggagccattg   3420

ccatccagtc agcctggaga ggatatgatg ctcggaggaa atttaagaaa ataagcaaca   3480

gaaggaatga gtctgctgct cataatcaag caggggacac ttcaaaccaa agcagtgggc   3540

cacattcccc cgtcgcagca ggtacgaggg gaagtgccga ggttcaagac tgcagcgagc   3600

ctggtgacca taaagttctc aggggctctg tacatcgtag gagccattca caagcagaat   3660

ccaacaatgg ccgtacacag acttcaagca actctcctgc tgtcacagag aaaaatgggc   3720

attcacaagc ccagagttct ccaaaagggt gcgatatctt cgcaggacat gcaaacaagc   3780

actcggtttc tgggactgat ttgctgtctt ctcggatatg ccatcctgct ccagatcagc   3840

aaggattgag tctctgggga gcccctcaaa agcctggttc agaaaatggt cttgcacaga   3900

agcatcgaac acctcgccga cgatgtcagc agcccaaaat gctgagtagc cctgaggaca   3960

ccatgtacta taaccagtta aatggaactc tagaatatca agggagcaag aggaagccaa   4020

gaaaacttgg ccaaatcaaa gtacttgatg gggaagatga atattacaaa tctctgtcac   4080

cagtggactg tatccctgag gagaacaact cagcccaccc ttcctttttt tcttcatcct   4140

caaaaggaga ctcttttgct caacattaaa ttgtgcttcc taaccctaaa tctgtccaga   4200

gtaggaacat tcatggtaat cgactgtctg tcattgcgta agaaagcact gatatggggt   4260

cagcttcttt ggacatatgg tccatgcctg aaccttactg aaccacttgc agattccaaa   4320

acatcttatc ctatcctcta ccactctccc acatgtgttg tgcagcctga gctgggcgct   4380

gccttccttt ctcatcccat ggggccctgt gggacactga gaacaccttt acaatagttt   4440

aaacagtcat tcatgccccc agtgtctagg aagataacag ccagtctcac cccagtctaa   4500

tcatggaccc tgataatatt gcttgatttt tcctatcaag ttacttttca atccattcag   4560

aatctgcccc agtggagacc caggagttcc tttcctgcac tcttctccat cctcccacct   4620

ttgctgggct tttctatcac tcccacctcc cccagagtca gggctccatt gctgagtgcc   4680

ccatcctgga ggattggccc caagatctcc tagaacagga taattgcctg tgtttaggca   4740

gataggccta aatctttcag attctttcta caaggcaaat aacccctctc ttgttaatta   4800

tgatgctgag aaagcctctg tctctttatt tcaccttgcc aagacaccca cactactttg   4860

gtgatgaaaa gaaaggaatg agagggaaag tttggacctg tcactttggt gacagggaaa   4920

gtccaggtca ctttattctg taactctcca ttcactggtc aaataactcc atgaggctat   4980

cagtggctac agtggaagga cctgatcttg tccatctttg tgtgcacaga gcctagcaca   5040

gggcttggta gagggtatat ctagtgaatg gagaatacat ggagaaactt aactaagtta   5100

cacaagcata tctgacagga atgttacctt caattgtatg ttacatatga ttagtcactt   5160

ttcatacact ataacctctg atttttcact caagtttggg ctgattatat tgtaatgatg   5220

ttagataata ctcaacatga ttcagtatga caaacttttt tgagcaccta ctttatataa   5280

aacatgacaa attgcagtgt gatgtaatca aaaacaaaga agccctataa gaccatttct   5340

ctagaacaga tgttcttaat atttttctta ctctaaaata tgtggtagat agtatgcaag   5400

aaaagccggg tgcggtggct caggcctgta atcccagcac tttgggaggc caagatgggc   5460

ggatcatgaa gtcaggagtt cgagaccagc ctgaccaaca tggtgaaacc ccgtctctac   5520

t                                                                   5521


<210>  8701
<211>  1341
<212>  PRT
<213>  Homosapiens

<400>  8701

Met Lys His Leu Tyr Gly Leu Phe His Tyr Asn Pro Met Met Leu Gly 
1               5                   10                  15      


Leu Glu Ser Leu Pro Asp Pro Thr Asp Thr Trp Glu Ile Ile Glu Thr 
            20                  25                  30          


Ile Gly Lys Gly Thr Tyr Gly Lys Val Tyr Lys Val Thr Asn Lys Arg 
        35                  40                  45              


Asp Gly Ser Leu Ala Ala Val Lys Ile Leu Asp Pro Val Ser Asp Met 
    50                  55                  60                  


Asp Glu Glu Ile Glu Ala Glu Tyr Asn Ile Leu Gln Phe Leu Pro Asn 
65                  70                  75                  80  


His Pro Asn Val Val Lys Phe Tyr Gly Met Phe Tyr Lys Ala Asp His 
                85                  90                  95      


Cys Val Gly Gly Gln Leu Trp Leu Val Leu Glu Leu Cys Asn Gly Gly 
            100                 105                 110         


Ser Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys Gly Gln Arg Leu 
        115                 120                 125             


Asp Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala Leu Leu Gly Leu 
    130                 135                 140                 


Gln His Leu His Asn Asn Arg Ile Ile His Arg Asp Val Lys Gly Asn 
145                 150                 155                 160 


Asn Ile Leu Leu Thr Thr Glu Gly Gly Val Lys Leu Val Asp Phe Gly 
                165                 170                 175     


Val Ser Ala Gln Leu Thr Ser Thr Arg Leu Arg Arg Asn Thr Ser Val 
            180                 185                 190         


Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Ala Cys Glu Gln Gln 
        195                 200                 205             


Tyr Asp Ser Ser Tyr Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile 
    210                 215                 220                 


Thr Ala Ile Glu Leu Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His 
225                 230                 235                 240 


Pro Val Lys Thr Leu Phe Lys Ile Pro Arg Asn Pro Pro Pro Thr Leu 
                245                 250                 255     


Leu His Pro Glu Lys Trp Cys Glu Glu Phe Asn His Phe Ile Ser Gln 
            260                 265                 270         


Cys Leu Ile Lys Asp Phe Glu Arg Arg Pro Ser Val Thr His Leu Leu 
        275                 280                 285             


Asp His Pro Phe Ile Lys Gly Val His Gly Lys Val Leu Phe Leu Gln 
    290                 295                 300                 


Lys Gln Leu Ala Lys Val Leu Gln Asp Gln Lys His Gln Asn Pro Val 
305                 310                 315                 320 


Ala Lys Thr Arg His Glu Arg Met His Thr Arg Arg Pro Tyr His Val 
                325                 330                 335     


Glu Asp Ala Glu Lys Tyr Cys Leu Glu Asp Asp Leu Val Asn Leu Glu 
            340                 345                 350         


Val Leu Asp Glu Asp Thr Ile Ile His Gln Leu Gln Lys Arg Tyr Ala 
        355                 360                 365             


Asp Leu Leu Ile Tyr Thr Tyr Val Gly Asp Ile Leu Ile Ala Leu Asn 
    370                 375                 380                 


Pro Phe Gln Asn Leu Ser Ile Tyr Ser Pro Gln Phe Ser Arg Leu Tyr 
385                 390                 395                 400 


His Gly Val Lys Arg Ala Ser Asn Pro Pro His Ile Phe Ala Ser Ala 
                405                 410                 415     


Asp Ala Ala Tyr Gln Cys Met Val Thr Leu Ser Lys Asp Gln Cys Ile 
            420                 425                 430         


Val Ile Ser Gly Glu Ser Gly Ser Gly Lys Thr Glu Ser Ala His Leu 
        435                 440                 445             


Ile Val Gln His Leu Thr Phe Leu Gly Lys Ala Asn Asn Gln Thr Leu 
    450                 455                 460                 


Arg Glu Lys Ile Leu Gln Val Asn Ser Leu Val Glu Ala Phe Gly Asn 
465                 470                 475                 480 


Ser Cys Thr Ala Ile Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Leu 
                485                 490                 495     


Glu Met Met Phe Thr Pro Thr Gly Val Val Met Gly Ala Arg Ile Ser 
            500                 505                 510         


Glu Tyr Leu Leu Glu Lys Ser Arg Val Ile Lys Gln Ala Ala Arg Glu 
        515                 520                 525             


Lys Asn Phe His Ile Phe Tyr Tyr Ile Tyr Ala Gly Leu His His Gln 
    530                 535                 540                 


Lys Lys Leu Ser Asp Phe Arg Leu Pro Glu Glu Lys Pro Pro Arg Tyr 
545                 550                 555                 560 


Ile Ala Asp Glu Thr Gly Arg Val Met His Asp Ile Thr Ser Lys Glu 
                565                 570                 575     


Ser Tyr Arg Arg Gln Phe Glu Ala Ile Gln His Cys Phe Arg Ile Ile 
            580                 585                 590         


Gly Phe Thr Asp Lys Glu Val His Ser Val Tyr Arg Ile Leu Ala Gly 
        595                 600                 605             


Ile Leu Asn Ile Gly Asn Ile Glu Phe Ala Ala Ile Ser Ser Gln His 
    610                 615                 620                 


Gln Thr Asp Lys Ser Glu Val Pro Asn Ala Glu Ala Leu Gln Asn Ala 
625                 630                 635                 640 


Ala Ser Val Leu Cys Ile Ser Pro Glu Glu Leu Gln Glu Ala Leu Thr 
                645                 650                 655     


Ser His Cys Val Val Thr Arg Gly Glu Thr Ile Ile Arg Ala Asn Thr 
            660                 665                 670         


Val Asp Arg Ala Ala Asp Val Arg Asp Ala Met Ser Lys Ala Leu Tyr 
        675                 680                 685             


Gly Arg Leu Phe Ser Trp Ile Val Asn Arg Ile Asn Thr Leu Leu Gln 
    690                 695                 700                 


Pro Asp Glu Asn Ile Cys Ser Ala Gly Gly Gly Met Asn Val Gly Ile 
705                 710                 715                 720 


Leu Asp Ile Phe Gly Phe Glu Asn Phe Gln Arg Asn Ser Phe Glu Gln 
                725                 730                 735     


Leu Cys Ile Asn Ile Ala Asn Glu Gln Ile Gln Tyr Tyr Phe Asn Gln 
            740                 745                 750         


His Val Phe Ala Leu Glu Gln Met Glu Tyr Gln Asn Glu Gly Ile Asp 
        755                 760                 765             


Ala Val Pro Val Glu Tyr Glu Asp Asn Arg Pro Leu Leu Asp Met Phe 
    770                 775                 780                 


Leu Gln Lys Pro Leu Gly Leu Leu Ala Leu Leu Asp Glu Glu Ser Arg 
785                 790                 795                 800 


Phe Pro Gln Ala Thr Asp Gln Thr Leu Val Asp Lys Phe Glu Asp Asn 
                805                 810                 815     


Leu Arg Cys Lys Tyr Phe Trp Arg Pro Lys Gly Val Glu Leu Cys Phe 
            820                 825                 830         


Gly Ile Gln His Tyr Ala Gly Lys Val Leu Tyr Asp Ala Ser Gly Val 
        835                 840                 845             


Leu Glu Lys Asn Arg Asp Thr Leu Pro Ala Asp Val Val Val Val Leu 
    850                 855                 860                 


Arg Thr Ser Glu Asn Lys Leu Leu Gln Gln Leu Phe Ser Ile Pro Leu 
865                 870                 875                 880 


Thr Lys Thr Gly Asn Leu Ala Gln Thr Arg Ala Arg Ile Thr Val Ala 
                885                 890                 895     


Ser Ser Ser Leu Pro Pro His Phe Ser Ala Gly Lys Ala Lys Val Asp 
            900                 905                 910         


Thr Leu Glu Val Ile Arg His Pro Glu Glu Thr Thr Asn Met Lys Arg 
        915                 920                 925             


Gln Thr Val Ala Ser Tyr Phe Arg Tyr Ser Leu Met Asp Leu Leu Ser 
    930                 935                 940                 


Lys Met Val Val Gly Gln Pro His Phe Val Arg Cys Ile Lys Pro Asn 
945                 950                 955                 960 


Asp Asp Arg Glu Ala Leu Gln Phe Ser Arg Glu Arg Val Leu Ala Gln 
                965                 970                 975     


Leu Arg Ser Thr Gly Ile Leu Glu Thr Val Ser Ile Arg Arg Gln Gly 
            980                 985                 990         


Tyr Ser His Arg Ile Leu Phe Glu  Glu Phe Val Lys Arg  Tyr Tyr Tyr 
        995                 1000                 1005             


Leu Ala  Phe Thr Ala His Gln  Thr Pro Leu Ala Ser  Lys Glu Ser 
    1010                 1015                 1020             


Cys Val  Ala Ile Leu Glu Lys  Ser Arg Leu Asp His  Trp Val Leu 
    1025                 1030                 1035             


Gly Lys  Thr Lys Val Phe Leu  Lys Tyr Tyr His Val  Glu Gln Leu 
    1040                 1045                 1050             


Asn Leu  Leu Leu Arg Glu Val  Ile Gly Arg Val Val  Val Leu Gln 
    1055                 1060                 1065             


Ala Tyr  Thr Lys Gly Trp Leu  Gly Ala Arg Arg Tyr  Lys Arg Val 
    1070                 1075                 1080             


Arg Glu  Lys Arg Glu Lys Gly  Ala Ile Ala Ile Gln  Ser Ala Trp 
    1085                 1090                 1095             


Arg Gly  Tyr Asp Ala Arg Arg  Lys Phe Lys Lys Ile  Ser Asn Arg 
    1100                 1105                 1110             


Arg Asn  Glu Ser Ala Ala His  Asn Gln Ala Gly Asp  Thr Ser Asn 
    1115                 1120                 1125             


Gln Ser  Ser Gly Pro His Ser  Pro Val Ala Ala Gly  Thr Arg Gly 
    1130                 1135                 1140             


Ser Ala  Glu Val Gln Asp Cys  Ser Glu Pro Gly Asp  His Lys Val 
    1145                 1150                 1155             


Leu Arg  Gly Ser Val His Arg  Arg Ser His Ser Gln  Ala Glu Ser 
    1160                 1165                 1170             


Asn Asn  Gly Arg Thr Gln Thr  Ser Ser Asn Ser Pro  Ala Val Thr 
    1175                 1180                 1185             


Glu Lys  Asn Gly His Ser Gln  Ala Gln Ser Ser Pro  Lys Gly Cys 
    1190                 1195                 1200             


Asp Ile  Phe Ala Gly His Ala  Asn Lys His Ser Val  Ser Gly Thr 
    1205                 1210                 1215             


Asp Leu  Leu Ser Ser Arg Ile  Cys His Pro Ala Pro  Asp Gln Gln 
    1220                 1225                 1230             


Gly Leu  Ser Leu Trp Gly Ala  Pro Gln Lys Pro Gly  Ser Glu Asn 
    1235                 1240                 1245             


Gly Leu  Ala Gln Lys His Arg  Thr Pro Arg Arg Arg  Cys Gln Gln 
    1250                 1255                 1260             


Pro Lys  Met Leu Ser Ser Pro  Glu Asp Thr Met Tyr  Tyr Asn Gln 
    1265                 1270                 1275             


Leu Asn  Gly Thr Leu Glu Tyr  Gln Gly Ser Lys Arg  Lys Pro Arg 
    1280                 1285                 1290             


Lys Leu  Gly Gln Ile Lys Val  Leu Asp Gly Glu Asp  Glu Tyr Tyr 
    1295                 1300                 1305             


Lys Ser  Leu Ser Pro Val Asp  Cys Ile Pro Glu Glu  Asn Asn Ser 
    1310                 1315                 1320             


Ala His  Pro Ser Phe Phe Ser  Ser Ser Ser Lys Gly  Asp Ser Phe 
    1325                 1330                 1335             


Ala Gln  His 
    1340     


<210>  8702
<211>  3320
<212>  DNA
<213>  Homosapiens

<400>  8702
gtgcatgctg cagagtgctt tactttcaac aaggaaacat ctgtatggat tatttcacta     60

taatcctatg atgcttggac ttgaatcact tccagatccc acagacacct gggaaattat    120

agagaccatt ggtaaaggca cctatggcaa agtctacaag gtaactaaca agagagatgg    180

gagcctggct gcagtgaaaa ttctggatcc agtcagtgat atggatgaag aaattgaggc    240

agaatacaac attttgcagt tccttcctaa tcatcccaat gttgtaaagt tttatgggat    300

gttttacaaa gcggatcact gtgtaggggg acagctgtgg ctggtcctgg agctgtgtaa    360

tgggggctca gtcactgagc ttgtcaaagg tctactcaga tgtggccagc ggttggatga    420

agcaatgatc tcatacatct tgtacggggc cctcttgggc cttcagcatt tgcacaacaa    480

ccgaatcatc caccgtgatg tgaaggggaa taacattctt ctgacaacag aaggaggagt    540

taagctcgtt gactttggtg tttcagctca actcaccagt acacgtctgc ggagaaacac    600

atctgttggc accccgttct ggatggcccc tgaggtcatt gcctgtgagc agcagtatga    660

ctcttcctat gacgctcgct gtgacgtctg gtccttgggg atcacagcta ttgaactggg    720

ggatggagac cctcccctct ttgacatgca tcctgtgaaa acactcttta agattccaag    780

aaatcctcca cctactttac ttcatccaga aaaatggtgt gaagaattca accactttat    840

ttcacagtgt cttattaagg attttgaaag gcgaccttcc gtcacacatc tccttgacca    900

cccatttatt aaaggagtac atggaaaagt tctgtttctg caaaaacagc tggccaaggt    960

tctccaagac cagaagcatc aaaatcctgt tgctaaaacc aggcatgaga ggatgcatac   1020

cagaagacct tatcatgtgg aagatgctga aaaatactgc cttgaggatg atttggtcaa   1080

cctagaggtt ctggatgagg atacaattat ccatcagttg cagaaacgtt atgcagactt   1140

gctaatttac acatatgttg gagacatctt aattgcctta aaccccttcc agaatctaag   1200

catatactct ccacagtttt ccagacttta tcatggggtg aaacgcgcct ccaatccccc   1260

ccacatattt gcatcagcag atgctgctta ccagtgcatg gttactctca gcaaagacca   1320

gtgcattgtc atcagcggag agagtggctc tgggaagaca gaaagcgccc acctgattgt   1380

tcagcatttg actttcttgg gaaaggccaa taatcagacc ttgagagaga aaattctaca   1440

agtcaactcc ctggtggaag cctttgggaa ctcatgcact gccatcaatg acaactcgag   1500

ccgttttgga aaatatctgg aaatgatgtt tacaccaact ggagttgtga tgggggcaag   1560

aatctctgaa tatctcctgg aaaaatccag agttataaaa caggcagcga gagagaaaaa   1620

ttttcatata ttttactata tttatgctgg tcttcatcac caaaagaagc tttctgattt   1680

cagacttcct gaggaaaaac ctcctaggta catagctgat gaaactggaa gggtgatgca   1740

cgacataact tccaaggagt cttacagaag acaattcgaa gcaattcagc attgcttcag   1800

gattataggg ttcacggaca aagaggtgca ctcagtgtac agaattttgg ctgggatttt   1860

gaatattggg aacattgagt tcgcagctat ttcctctcaa catcagactg ataaaagtga   1920

ggtgcccaat gctgaagctt tgcaaaatgc tgcctctgtt ctgtgcatta gccctgaaga   1980

gctccaggag gccctcacct cccactgtgt ggtcacccgg ggcgagacca tcatccgtgc   2040

caacactgta gacagggctg cggacgttcg agacgccatg tccaaagccc tgtatgggag   2100

gctcttcagc tggattgtga atcgcattaa tacactcctg cagccagacg aaaacatatg   2160

tagtgcagga ggtggaatga atgtggggat cttggatatc tttggattcg agaattttca   2220

gagaaattca tttgagcagc tctgcataaa catcgccaat gagcaaatcc agtactattt   2280

caatcagcat gtttttgctc ttgagcagat ggaatatcag aatgaaggca ttgatgctgt   2340

acccgtggaa tatgaggaca accgcccgct cttggacatg ttcctccaga aacccctggg   2400

actgcttgca cttttggatg aggaaagtcg gtttccccaa gcaactgacc agaccctggt   2460

tgataaattt gaagataatc tacgatgcaa atacttctgg aggcccaaag gagtggaact   2520

gtgctttggc attcagcatt atgctggaaa ggtattatat gatgcttctg gggttcttga   2580

gaaaaataga gacactctcc ctgccgatgt ggttgtggtc ctgagaacgt cagaaaacaa   2640

gcttcttcag cagctcttct caatccctct gaccaaaaca ggtaatttgg cccagacaag   2700

agctaggata acagtggcct caagttcttt gcctccacat ttcagtgctg ggaaagccaa   2760

ggtggacact ctggaggtga tacggcatcc ggaagaaacc accaacatga agaggcaaac   2820

tgtggcttct tacttccggt attctctgat ggacctgctc tccaaaatgg tggttggaca   2880

gccccacttt gtgcgctgca ttaaacccaa tgatgaccga gaggccctgc agttctctcg   2940

agagagggtg ctggcccagc tccgctccac agggattctg gagacagtca gcatccgccg   3000

ccagggctat tcccaccgca tcctttttga agaatttgtg aaaaggtatt attacttggc   3060

attcacagca catcaaacac ctcttgctag caaagagagc tgtgtggcta tcttggaaaa   3120

gtccagatta gatcactggg tactgggaaa aacaaaggtt tttctcaaat attaccatgt   3180

tgagcaatta aatttgctgc ttcgagaagt cataggcaga gtggttgtgc tgcaggcata   3240

taccaagggg tggcttggag ccaggagata caaaagggtc agagagaaga gagagaaggg   3300

agccattgcc atccagtcag                                               3320


<210>  8703
<211>  1104
<212>  PRT
<213>  Homosapiens

<400>  8703

Met Leu Gln Ser Ala Leu Leu Ser Thr Arg Lys His Leu Tyr Gly Leu 
1               5                   10                  15      


Phe His Tyr Asn Pro Met Met Leu Gly Leu Glu Ser Leu Pro Asp Pro 
            20                  25                  30          


Thr Asp Thr Trp Glu Ile Ile Glu Thr Ile Gly Lys Gly Thr Tyr Gly 
        35                  40                  45              


Lys Val Tyr Lys Val Thr Asn Lys Arg Asp Gly Ser Leu Ala Ala Val 
    50                  55                  60                  


Lys Ile Leu Asp Pro Val Ser Asp Met Asp Glu Glu Ile Glu Ala Glu 
65                  70                  75                  80  


Tyr Asn Ile Leu Gln Phe Leu Pro Asn His Pro Asn Val Val Lys Phe 
                85                  90                  95      


Tyr Gly Met Phe Tyr Lys Ala Asp His Cys Val Gly Gly Gln Leu Trp 
            100                 105                 110         


Leu Val Leu Glu Leu Cys Asn Gly Gly Ser Val Thr Glu Leu Val Lys 
        115                 120                 125             


Gly Leu Leu Arg Cys Gly Gln Arg Leu Asp Glu Ala Met Ile Ser Tyr 
    130                 135                 140                 


Ile Leu Tyr Gly Ala Leu Leu Gly Leu Gln His Leu His Asn Asn Arg 
145                 150                 155                 160 


Ile Ile His Arg Asp Val Lys Gly Asn Asn Ile Leu Leu Thr Thr Glu 
                165                 170                 175     


Gly Gly Val Lys Leu Val Asp Phe Gly Val Ser Ala Gln Leu Thr Ser 
            180                 185                 190         


Thr Arg Leu Arg Arg Asn Thr Ser Val Gly Thr Pro Phe Trp Met Ala 
        195                 200                 205             


Pro Glu Val Ile Ala Cys Glu Gln Gln Tyr Asp Ser Ser Tyr Asp Ala 
    210                 215                 220                 


Arg Cys Asp Val Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu Gly Asp 
225                 230                 235                 240 


Gly Asp Pro Pro Leu Phe Asp Met His Pro Val Lys Thr Leu Phe Lys 
                245                 250                 255     


Ile Pro Arg Asn Pro Pro Pro Thr Leu Leu His Pro Glu Lys Trp Cys 
            260                 265                 270         


Glu Glu Phe Asn His Phe Ile Ser Gln Cys Leu Ile Lys Asp Phe Glu 
        275                 280                 285             


Arg Arg Pro Ser Val Thr His Leu Leu Asp His Pro Phe Ile Lys Gly 
    290                 295                 300                 


Val His Gly Lys Val Leu Phe Leu Gln Lys Gln Leu Ala Lys Val Leu 
305                 310                 315                 320 


Gln Asp Gln Lys His Gln Asn Pro Val Ala Lys Thr Arg His Glu Arg 
                325                 330                 335     


Met His Thr Arg Arg Pro Tyr His Val Glu Asp Ala Glu Lys Tyr Cys 
            340                 345                 350         


Leu Glu Asp Asp Leu Val Asn Leu Glu Val Leu Asp Glu Asp Thr Ile 
        355                 360                 365             


Ile His Gln Leu Gln Lys Arg Tyr Ala Asp Leu Leu Ile Tyr Thr Tyr 
    370                 375                 380                 


Val Gly Asp Ile Leu Ile Ala Leu Asn Pro Phe Gln Asn Leu Ser Ile 
385                 390                 395                 400 


Tyr Ser Pro Gln Phe Ser Arg Leu Tyr His Gly Val Lys Arg Ala Ser 
                405                 410                 415     


Asn Pro Pro His Ile Phe Ala Ser Ala Asp Ala Ala Tyr Gln Cys Met 
            420                 425                 430         


Val Thr Leu Ser Lys Asp Gln Cys Ile Val Ile Ser Gly Glu Ser Gly 
        435                 440                 445             


Ser Gly Lys Thr Glu Ser Ala His Leu Ile Val Gln His Leu Thr Phe 
    450                 455                 460                 


Leu Gly Lys Ala Asn Asn Gln Thr Leu Arg Glu Lys Ile Leu Gln Val 
465                 470                 475                 480 


Asn Ser Leu Val Glu Ala Phe Gly Asn Ser Cys Thr Ala Ile Asn Asp 
                485                 490                 495     


Asn Ser Ser Arg Phe Gly Lys Tyr Leu Glu Met Met Phe Thr Pro Thr 
            500                 505                 510         


Gly Val Val Met Gly Ala Arg Ile Ser Glu Tyr Leu Leu Glu Lys Ser 
        515                 520                 525             


Arg Val Ile Lys Gln Ala Ala Arg Glu Lys Asn Phe His Ile Phe Tyr 
    530                 535                 540                 


Tyr Ile Tyr Ala Gly Leu His His Gln Lys Lys Leu Ser Asp Phe Arg 
545                 550                 555                 560 


Leu Pro Glu Glu Lys Pro Pro Arg Tyr Ile Ala Asp Glu Thr Gly Arg 
                565                 570                 575     


Val Met His Asp Ile Thr Ser Lys Glu Ser Tyr Arg Arg Gln Phe Glu 
            580                 585                 590         


Ala Ile Gln His Cys Phe Arg Ile Ile Gly Phe Thr Asp Lys Glu Val 
        595                 600                 605             


His Ser Val Tyr Arg Ile Leu Ala Gly Ile Leu Asn Ile Gly Asn Ile 
    610                 615                 620                 


Glu Phe Ala Ala Ile Ser Ser Gln His Gln Thr Asp Lys Ser Glu Val 
625                 630                 635                 640 


Pro Asn Ala Glu Ala Leu Gln Asn Ala Ala Ser Val Leu Cys Ile Ser 
                645                 650                 655     


Pro Glu Glu Leu Gln Glu Ala Leu Thr Ser His Cys Val Val Thr Arg 
            660                 665                 670         


Gly Glu Thr Ile Ile Arg Ala Asn Thr Val Asp Arg Ala Ala Asp Val 
        675                 680                 685             


Arg Asp Ala Met Ser Lys Ala Leu Tyr Gly Arg Leu Phe Ser Trp Ile 
    690                 695                 700                 


Val Asn Arg Ile Asn Thr Leu Leu Gln Pro Asp Glu Asn Ile Cys Ser 
705                 710                 715                 720 


Ala Gly Gly Gly Met Asn Val Gly Ile Leu Asp Ile Phe Gly Phe Glu 
                725                 730                 735     


Asn Phe Gln Arg Asn Ser Phe Glu Gln Leu Cys Ile Asn Ile Ala Asn 
            740                 745                 750         


Glu Gln Ile Gln Tyr Tyr Phe Asn Gln His Val Phe Ala Leu Glu Gln 
        755                 760                 765             


Met Glu Tyr Gln Asn Glu Gly Ile Asp Ala Val Pro Val Glu Tyr Glu 
    770                 775                 780                 


Asp Asn Arg Pro Leu Leu Asp Met Phe Leu Gln Lys Pro Leu Gly Leu 
785                 790                 795                 800 


Leu Ala Leu Leu Asp Glu Glu Ser Arg Phe Pro Gln Ala Thr Asp Gln 
                805                 810                 815     


Thr Leu Val Asp Lys Phe Glu Asp Asn Leu Arg Cys Lys Tyr Phe Trp 
            820                 825                 830         


Arg Pro Lys Gly Val Glu Leu Cys Phe Gly Ile Gln His Tyr Ala Gly 
        835                 840                 845             


Lys Val Leu Tyr Asp Ala Ser Gly Val Leu Glu Lys Asn Arg Asp Thr 
    850                 855                 860                 


Leu Pro Ala Asp Val Val Val Val Leu Arg Thr Ser Glu Asn Lys Leu 
865                 870                 875                 880 


Leu Gln Gln Leu Phe Ser Ile Pro Leu Thr Lys Thr Gly Asn Leu Ala 
                885                 890                 895     


Gln Thr Arg Ala Arg Ile Thr Val Ala Ser Ser Ser Leu Pro Pro His 
            900                 905                 910         


Phe Ser Ala Gly Lys Ala Lys Val Asp Thr Leu Glu Val Ile Arg His 
        915                 920                 925             


Pro Glu Glu Thr Thr Asn Met Lys Arg Gln Thr Val Ala Ser Tyr Phe 
    930                 935                 940                 


Arg Tyr Ser Leu Met Asp Leu Leu Ser Lys Met Val Val Gly Gln Pro 
945                 950                 955                 960 


His Phe Val Arg Cys Ile Lys Pro Asn Asp Asp Arg Glu Ala Leu Gln 
                965                 970                 975     


Phe Ser Arg Glu Arg Val Leu Ala Gln Leu Arg Ser Thr Gly Ile Leu 
            980                 985                 990         


Glu Thr Val Ser Ile Arg Arg Gln  Gly Tyr Ser His Arg  Ile Leu Phe 
        995                 1000                 1005             


Glu Glu  Phe Val Lys Arg Tyr  Tyr Tyr Leu Ala Phe  Thr Ala His 
    1010                 1015                 1020             


Gln Thr  Pro Leu Ala Ser Lys  Glu Ser Cys Val Ala  Ile Leu Glu 
    1025                 1030                 1035             


Lys Ser  Arg Leu Asp His Trp  Val Leu Gly Lys Thr  Lys Val Phe 
    1040                 1045                 1050             


Leu Lys  Tyr Tyr His Val Glu  Gln Leu Asn Leu Leu  Leu Arg Glu 
    1055                 1060                 1065             


Val Ile  Gly Arg Val Val Val  Leu Gln Ala Tyr Thr  Lys Gly Trp 
    1070                 1075                 1080             


Leu Gly  Ala Arg Arg Tyr Lys  Arg Val Arg Glu Lys  Arg Glu Lys 
    1085                 1090                 1095             


Gly Ala  Ile Ala Ile Gln 
    1100                 


<210>  8704
<211>  1726
<212>  DNA
<213>  Homosapiens

<400>  8704
caaccaggaa acatctgtat ggattatttc actataatcc tatgatgctt ggacttgaat     60

cacttccaga tcccacagac acctgggaaa ttatagagac cattggtaaa ggcacctatg    120

gcaaagtcta caaggtaact aacaagagag atgggagcct ggctgcagtg aaaattctgg    180

atccagtcag tgatatggat gaagaaattg aggcagaata caacattttg cagttccttc    240

ctaatcatcc caatgttgta aagttttatg ggatgtttta caaagcggat cactgtgtag    300

ggggacagct gtggctggtc ctggagctgt gtaatggggg ctcagtcact gagcttgtca    360

aaggtctact cagatgtggc cagcggttgg atgaagcaat gatctcatac atcttgtacg    420

gggccctctt gggccttcag catttgcaca acaaccgaat catccaccgt gatgtgaagg    480

ggaataacat tcttctgaca acagaaggag gagttaagct cgttgacttt ggtgtttcag    540

ctcaactcac cagtacacgt ctgcggagaa acacatctgt tggcaccccg ttctggatgg    600

cccctgaggt cattgcctgt gagcagcagt atgactcttc ctatgacgct cgctgtgacg    660

tctggtcctt ggggatcaca gctattgaac tgggggatgg agaccctccc ctctttgaca    720

tgcatcctgt gaaaacactc tttaagattc caagaaatcc tccacctact ttacttcatc    780

cagaaaaatg gtgtgaagaa ttcaaccact ttatttcaca gtgtcttatt aaggattttg    840

aaaggcgacc ttccgtcaca catctccttg accacccatt tattaaagga gtacatggaa    900

aagttctgtt tctgcaaaaa cagctggcca aggttctcca agaccagaag catcaaaatc    960

ctgttgctaa aaccaggcat gagaggatgc ataccagaag accttatcat gtggaagatg   1020

ctgaaaaata ctgccttgag gatgatttgg tcaacctaga ggttctggat gaggtactaa   1080

atatttagta gacaattctc attgaagaca tttgtttcat gtgaatggtc tgaactttct   1140

gttgtagacc atgtcctcct aaggtcattt gaaaatttaa ttgtttgtgt agctatggga   1200

tgaagttcag ggagcattca gttgctgtga ctatgatcct gtgctgtgtt tatttagata   1260

gcccctagaa tgatgaagag aaaaggattt ggatttttgc aataaagctc tttatattgt   1320

agccttaatg atggattata tcagctgaaa atattttgtt tgataaaatt tgataaaata   1380

tttcaattaa cccttaagaa gttgtttgtt cttcataaga aagagcttca tttagggaaa   1440

tagtgaagtt aatatagctt gaattctaaa tttgaagtct gtgataatcc ccatttaaaa   1500

tatgcatgtt taatagagct gttaattgca ctggacctgt ttatgctgag tctaactctg   1560

gggattgtta ccttcaatgt ctaaatcact aaagtgtaat acaaagtggt taattctgta   1620

tttatgccac ctaggtttta agtgcagtgc tttgagaaat taacttacca ttctgtcggt   1680

gctctatcag taggaacagc ctattaaata aaattttaaa tacaac                  1726


<210>  8705
<211>  348
<212>  PRT
<213>  Homosapiens

<400>  8705

Met Met Leu Gly Leu Glu Ser Leu Pro Asp Pro Thr Asp Thr Trp Glu 
1               5                   10                  15      


Ile Ile Glu Thr Ile Gly Lys Gly Thr Tyr Gly Lys Val Tyr Lys Val 
            20                  25                  30          


Thr Asn Lys Arg Asp Gly Ser Leu Ala Ala Val Lys Ile Leu Asp Pro 
        35                  40                  45              


Val Ser Asp Met Asp Glu Glu Ile Glu Ala Glu Tyr Asn Ile Leu Gln 
    50                  55                  60                  


Phe Leu Pro Asn His Pro Asn Val Val Lys Phe Tyr Gly Met Phe Tyr 
65                  70                  75                  80  


Lys Ala Asp His Cys Val Gly Gly Gln Leu Trp Leu Val Leu Glu Leu 
                85                  90                  95      


Cys Asn Gly Gly Ser Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys 
            100                 105                 110         


Gly Gln Arg Leu Asp Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala 
        115                 120                 125             


Leu Leu Gly Leu Gln His Leu His Asn Asn Arg Ile Ile His Arg Asp 
    130                 135                 140                 


Val Lys Gly Asn Asn Ile Leu Leu Thr Thr Glu Gly Gly Val Lys Leu 
145                 150                 155                 160 


Val Asp Phe Gly Val Ser Ala Gln Leu Thr Ser Thr Arg Leu Arg Arg 
                165                 170                 175     


Asn Thr Ser Val Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Ala 
            180                 185                 190         


Cys Glu Gln Gln Tyr Asp Ser Ser Tyr Asp Ala Arg Cys Asp Val Trp 
        195                 200                 205             


Ser Leu Gly Ile Thr Ala Ile Glu Leu Gly Asp Gly Asp Pro Pro Leu 
    210                 215                 220                 


Phe Asp Met His Pro Val Lys Thr Leu Phe Lys Ile Pro Arg Asn Pro 
225                 230                 235                 240 


Pro Pro Thr Leu Leu His Pro Glu Lys Trp Cys Glu Glu Phe Asn His 
                245                 250                 255     


Phe Ile Ser Gln Cys Leu Ile Lys Asp Phe Glu Arg Arg Pro Ser Val 
            260                 265                 270         


Thr His Leu Leu Asp His Pro Phe Ile Lys Gly Val His Gly Lys Val 
        275                 280                 285             


Leu Phe Leu Gln Lys Gln Leu Ala Lys Val Leu Gln Asp Gln Lys His 
    290                 295                 300                 


Gln Asn Pro Val Ala Lys Thr Arg His Glu Arg Met His Thr Arg Arg 
305                 310                 315                 320 


Pro Tyr His Val Glu Asp Ala Glu Lys Tyr Cys Leu Glu Asp Asp Leu 
                325                 330                 335     


Val Asn Leu Glu Val Leu Asp Glu Val Leu Asn Ile 
            340                 345             


<210>  8706
<211>  5271
<212>  DNA
<213>  Homosapiens

<400>  8706
gacttgaatc acttccagat cccacagaca cctgggaaat tatagagacc attggtaaag     60

gcacctatgg caaagtctac aaggtaacta acaagagaga tgggagcctg gctgcagtga    120

aaattctgga tccagtcagt gatatggatg aagaaattga ggcagaatac aacattttgc    180

agttccttcc taatcatccc aatgttgtaa agttttatgg gatgttttac aaagcggatc    240

actgtgtagg gggacagctg tggctggtcc tggagctgtg taatgggggc tcagtcactg    300

agcttgtcaa aggtctactc agatgtggcc agcggttgga tgaagcaatg atctcataca    360

tcttgtacgg ggccctcttg gtgtttcagc tcaactcacc agtacacgtc tgcggagaaa    420

cacatctgtt ggcaccccgt tctggatggc ccctgaggtc attgcctgtg agcagcagta    480

tgactcttcc tatgacgctc gctgtgacgt ctggtccttg gggatcacag ctattgaact    540

gggggatgga gaccctcccc tctttgacat gcatcctgtg aaaacactct ttaagattcc    600

aagaaatcct ccacctactt tacttcatcc agaaaaatgg tgtgaagaat tcaaccactt    660

tatttcacag tgtcttatta aggattttga aaggcgacct tccgtcacac atctccttga    720

ccacccattt attaaaggag tacatggaaa agttctgttt ctgcaaaaac agctggccaa    780

ggttctccaa gaccagaagc atcaaaatcc tgttgctaaa accaggcatg agaggatgca    840

taccagaaga ccttatcatg tggaagatgc tgaaaaatac tgccttgagg atgatttggt    900

caacctagag gttctggatg aggatacaat tatccatcag ttgcagaaac gttatgcaga    960

cttgctaatt tacacatatg ttggagacat cttaattgcc ttaaacccct tccagaatct   1020

aagcatatac tctccacagt tttccagact ttatcatggg gtgaaacgcg cctccaatcc   1080

cccccacata tttgcatcag cagatgctgc ttaccagtgc atggttactc tcagcaaaga   1140

ccagtgcatt gtcatcagcg gagagagtgg ctctgggaag acagaaagcg cccacctgat   1200

tgttcagcat ttgactttct tgggaaaggc caataatcag accttgagag agaaaattct   1260

acaagtcaac tccctggtgg aagcctttgg gaactcatgc actgccatca atgacaactc   1320

gagccgtttt ggaaaatatc tggaaatgat gtttacacca actggagttg tgatgggggc   1380

aagaatctct gaatatctcc tggaaaaatc cagagttata aaacaggcag cgagagagaa   1440

aaattttcat atattttact atatttatgc tggtcttcat caccaaaaga agctttctga   1500

tttcagactt cctgaggaaa aacctcctag gtacatagct gatgaaactg gaagggtgat   1560

gcacgacata acttccaagg agtcttacag aagacaattc gaagcaattc agcattgctt   1620

caggattata gggttcacgg acaaagaggt gcactcagtg tacagaattt tggctgggat   1680

tttgaatatt gggaacattg agttcgcagc tatttcctct caacatcaga ctgataaaag   1740

tgaggtgccc aatgctgaag ctttgcaaaa tgctgcctct gttctgtgca ttagccctga   1800

agagctccag gaggccctca cctcccactg tgtggtcacc cggggcgaga ccatcatccg   1860

tgccaacact gtagacaggg ctgcggacgt tcgagacgcc atgtccaaag ccctgtatgg   1920

gaggctcttc agctggattg tgaatcgcat taatacactc ctgcagccag acgaaaacat   1980

atgtagtgca ggaggtggaa tgaatgtggg gatcttggat atctttggat tcgagaattt   2040

tcagagaaat tcatttgagc agctctgcat aaacatcgcc aatgagcaaa tccagtacta   2100

tttcaatcag catgtttttg ctcttgagca gatggaatat cagaatgaag gcattgatgc   2160

tgtacccgtg gaatatgagg acaaccgccc gctcttggac atgttcctcc agaaacccct   2220

gggactgctt gcacttttgg atgaggaaag tcggtttccc caagcaactg accagaccct   2280

ggttgataaa tttgaagata atctacgatg caaatacttc tggaggccca aaggagtgga   2340

actgtgcttt ggcattcagc attatgctgg aaaggtatta tatgatgctt ctggggttct   2400

tgagaaaaat agagacactc tccctgccga tgtggttgtg gtcctgagaa cgtcagaaaa   2460

caagcttctt cagcagctct tctcaatccc tctgaccaaa acaggtaatt tggcccagac   2520

aagagctagg ataacagtgg cctcaagttc tttgcctcca catttcagtg ctgggaaagc   2580

caaggggaca cttcaaacca aagcagtggg ccacattccc ccgtcgcagc aggtacgagg   2640

ggaagtgccg aggttcaaga ctgcagcgag cctggtgacc ataaagttct caggggctct   2700

gtacatcgta ggagccattc acaagcagaa tccaacaatg gccgtacaca gacttcaagc   2760

aactctcctg ctgtcacaga gaaaaatggg cattcacaag cccagagttc tccaaaaggg   2820

tgcgatatct tcgcaggaca tgcaaacaag cactcggttt ctgggactga tttgctgtct   2880

tctcggatat gccatcctgc tccagatcag caaggattga gtctctgggg agcccctcaa   2940

aagcctggtt cagaaaatgg tcttgcacag aagcatcgaa cacctcgccg acgatgtcag   3000

cagcccaaaa tgctgagtag ccctgaggac accatgtact ataaccagtt aaatggaact   3060

ctagaatatc aagggagcaa gaggaagcca agaaaacttg gccaaatcaa agtacttgat   3120

ggggaagatg aatattacaa atctctgtca ccagtggact gtatccctga ggagaacaac   3180

tcagcccacc cttccttttt ttcttcatcc tcaaaaggag actcttttgc tcaacattaa   3240

attgtgcttc ctaaccctaa atctgtccag agtaggaaca ttcatggtaa tcgactgtct   3300

gtcattgcgt aagaaagcac tgatatgggg tcagcttctt tggacatatg gtccatgcct   3360

gaaccttact gaaccacttg cagattccaa aacatcttat cctatcctct accactctcc   3420

cacatgtgtt gtgcagcctg agctgggcgc tgccttcctt tctcatccca tggggccctg   3480

tgggacactg agaacacctt tacaatagtt taaacagtca ttcatgcccc cagtgtctag   3540

gaagataaca gccagtctca ccccagtcta atcatggacc ctgataatat tgcttgattt   3600

ttcctatcaa gttacttttc aatccattca gaatctgccc cagtggagac ccaggagttc   3660

ctttcctgca ctcttctcca tcctcccacc tttgctgggc ttttctatca ctcccacctc   3720

ccccagagtc agggctccat tgctgagtgc cccatcctgg aggattggcc ccaagatctc   3780

ctagaacagg ataattgcct gtgtttaggc agataggcct aaatctttca gattctttct   3840

acaaggcaaa taacccctct cttgttaatt atgatgctga gaaagcctct gtctctttat   3900

ttcaccttgc caagacaccc acactacttt ggtgatgaaa agaaaggaat gagagggaaa   3960

gtttggacct gtcactttgg tgacagggaa agtccaggtc actttattct gtaactctcc   4020

attcactggt caaataactc catgaggcta tcagtggcta cagtggaagg acctgatctt   4080

gtccatcttt gtgtgcacag agcctagcac agggcttggt agagggtata tctagtgaat   4140

ggagaataca tggagaaact taactaagtt acacaagcat atctgacagg aatgttacct   4200

tcaattgtat gttacatatg attagtcact tttcatacac tataacctct gatttttcac   4260

tcaagtttgg gctgattata ttgtaatgat gttagataat actcaacatg attcagtatg   4320

acaaactttt ttgagcacct actttatata aaacatgaca aattgcagtg tgatgtaatc   4380

aaaaacaaag aagccctata agaccatttc tctagaacag atgttcttaa tatttttctt   4440

actctaaaat atgtggtaga tagtatgcaa gaaaagccgg gtgcggtggc tcaggcctgt   4500

aatcccagca ctttgggagg ccaagatggg cggatcatga agtcaggagt tcgagaccag   4560

cctgaccaac atggtgaaac cccgtctcta ctaaaaaaaa taatgataat acaaaaatta   4620

gcccagcatg gtggtgcata cctgtaatcc cagctactca ggaggctgac gcaggagaat   4680

cacttgaacc cgggaagcaa aggttgcagt cagctgagag cgcaccactg cactccagcc   4740

tgggcgacag ggcaagactc tgtctcaaaa aaaaaaaaaa aaaaaaaaaa aagagatagt   4800

atgcaagaag acacctaaat tttgagagaa ataaccttga agaaaatctt gttatcagag   4860

ttttgaaagg gagcacatta ataggccttt tatgaagata aataatgaaa tgaggtattt   4920

aaagatctca gaaattgtaa ttttacaagt aaaataaata tagccaattt ttcaatagct   4980

gaacttcacc caaaaggtaa tgtttataag tagagcagaa aaaatgcaga taaattttat   5040

tttattgttt aaaaaataat gtgtagaata tataaatttt ttatgttact gttaatatac   5100

gagtgctttt ggaagtttca cttttgtcac tgattgtcta cttttggttt gataatatga   5160

gctgcttttc aaattgttga atggaaatgt tcataactcc ctgcttgtcc gtgcacaatg   5220

taattctaaa cctggcttgt ttctcattta aatatatcta taaataaact t            5271


<210>  8707
<211>  824
<212>  PRT
<213>  Homosapiens

<400>  8707

Met Ala Pro Glu Val Ile Ala Cys Glu Gln Gln Tyr Asp Ser Ser Tyr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu 
            20                  25                  30          


Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His Pro Val Lys Thr Leu 
        35                  40                  45              


Phe Lys Ile Pro Arg Asn Pro Pro Pro Thr Leu Leu His Pro Glu Lys 
    50                  55                  60                  


Trp Cys Glu Glu Phe Asn His Phe Ile Ser Gln Cys Leu Ile Lys Asp 
65                  70                  75                  80  


Phe Glu Arg Arg Pro Ser Val Thr His Leu Leu Asp His Pro Phe Ile 
                85                  90                  95      


Lys Gly Val His Gly Lys Val Leu Phe Leu Gln Lys Gln Leu Ala Lys 
            100                 105                 110         


Val Leu Gln Asp Gln Lys His Gln Asn Pro Val Ala Lys Thr Arg His 
        115                 120                 125             


Glu Arg Met His Thr Arg Arg Pro Tyr His Val Glu Asp Ala Glu Lys 
    130                 135                 140                 


Tyr Cys Leu Glu Asp Asp Leu Val Asn Leu Glu Val Leu Asp Glu Asp 
145                 150                 155                 160 


Thr Ile Ile His Gln Leu Gln Lys Arg Tyr Ala Asp Leu Leu Ile Tyr 
                165                 170                 175     


Thr Tyr Val Gly Asp Ile Leu Ile Ala Leu Asn Pro Phe Gln Asn Leu 
            180                 185                 190         


Ser Ile Tyr Ser Pro Gln Phe Ser Arg Leu Tyr His Gly Val Lys Arg 
        195                 200                 205             


Ala Ser Asn Pro Pro His Ile Phe Ala Ser Ala Asp Ala Ala Tyr Gln 
    210                 215                 220                 


Cys Met Val Thr Leu Ser Lys Asp Gln Cys Ile Val Ile Ser Gly Glu 
225                 230                 235                 240 


Ser Gly Ser Gly Lys Thr Glu Ser Ala His Leu Ile Val Gln His Leu 
                245                 250                 255     


Thr Phe Leu Gly Lys Ala Asn Asn Gln Thr Leu Arg Glu Lys Ile Leu 
            260                 265                 270         


Gln Val Asn Ser Leu Val Glu Ala Phe Gly Asn Ser Cys Thr Ala Ile 
        275                 280                 285             


Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Leu Glu Met Met Phe Thr 
    290                 295                 300                 


Pro Thr Gly Val Val Met Gly Ala Arg Ile Ser Glu Tyr Leu Leu Glu 
305                 310                 315                 320 


Lys Ser Arg Val Ile Lys Gln Ala Ala Arg Glu Lys Asn Phe His Ile 
                325                 330                 335     


Phe Tyr Tyr Ile Tyr Ala Gly Leu His His Gln Lys Lys Leu Ser Asp 
            340                 345                 350         


Phe Arg Leu Pro Glu Glu Lys Pro Pro Arg Tyr Ile Ala Asp Glu Thr 
        355                 360                 365             


Gly Arg Val Met His Asp Ile Thr Ser Lys Glu Ser Tyr Arg Arg Gln 
    370                 375                 380                 


Phe Glu Ala Ile Gln His Cys Phe Arg Ile Ile Gly Phe Thr Asp Lys 
385                 390                 395                 400 


Glu Val His Ser Val Tyr Arg Ile Leu Ala Gly Ile Leu Asn Ile Gly 
                405                 410                 415     


Asn Ile Glu Phe Ala Ala Ile Ser Ser Gln His Gln Thr Asp Lys Ser 
            420                 425                 430         


Glu Val Pro Asn Ala Glu Ala Leu Gln Asn Ala Ala Ser Val Leu Cys 
        435                 440                 445             


Ile Ser Pro Glu Glu Leu Gln Glu Ala Leu Thr Ser His Cys Val Val 
    450                 455                 460                 


Thr Arg Gly Glu Thr Ile Ile Arg Ala Asn Thr Val Asp Arg Ala Ala 
465                 470                 475                 480 


Asp Val Arg Asp Ala Met Ser Lys Ala Leu Tyr Gly Arg Leu Phe Ser 
                485                 490                 495     


Trp Ile Val Asn Arg Ile Asn Thr Leu Leu Gln Pro Asp Glu Asn Ile 
            500                 505                 510         


Cys Ser Ala Gly Gly Gly Met Asn Val Gly Ile Leu Asp Ile Phe Gly 
        515                 520                 525             


Phe Glu Asn Phe Gln Arg Asn Ser Phe Glu Gln Leu Cys Ile Asn Ile 
    530                 535                 540                 


Ala Asn Glu Gln Ile Gln Tyr Tyr Phe Asn Gln His Val Phe Ala Leu 
545                 550                 555                 560 


Glu Gln Met Glu Tyr Gln Asn Glu Gly Ile Asp Ala Val Pro Val Glu 
                565                 570                 575     


Tyr Glu Asp Asn Arg Pro Leu Leu Asp Met Phe Leu Gln Lys Pro Leu 
            580                 585                 590         


Gly Leu Leu Ala Leu Leu Asp Glu Glu Ser Arg Phe Pro Gln Ala Thr 
        595                 600                 605             


Asp Gln Thr Leu Val Asp Lys Phe Glu Asp Asn Leu Arg Cys Lys Tyr 
    610                 615                 620                 


Phe Trp Arg Pro Lys Gly Val Glu Leu Cys Phe Gly Ile Gln His Tyr 
625                 630                 635                 640 


Ala Gly Lys Val Leu Tyr Asp Ala Ser Gly Val Leu Glu Lys Asn Arg 
                645                 650                 655     


Asp Thr Leu Pro Ala Asp Val Val Val Val Leu Arg Thr Ser Glu Asn 
            660                 665                 670         


Lys Leu Leu Gln Gln Leu Phe Ser Ile Pro Leu Thr Lys Thr Gly Asn 
        675                 680                 685             


Leu Ala Gln Thr Arg Ala Arg Ile Thr Val Ala Ser Ser Ser Leu Pro 
    690                 695                 700                 


Pro His Phe Ser Ala Gly Lys Ala Lys Gly Thr Leu Gln Thr Lys Ala 
705                 710                 715                 720 


Val Gly His Ile Pro Pro Ser Gln Gln Val Arg Gly Glu Val Pro Arg 
                725                 730                 735     


Phe Lys Thr Ala Ala Ser Leu Val Thr Ile Lys Phe Ser Gly Ala Leu 
            740                 745                 750         


Tyr Ile Val Gly Ala Ile His Lys Gln Asn Pro Thr Met Ala Val His 
        755                 760                 765             


Arg Leu Gln Ala Thr Leu Leu Leu Ser Gln Arg Lys Met Gly Ile His 
    770                 775                 780                 


Lys Pro Arg Val Leu Gln Lys Gly Ala Ile Ser Ser Gln Asp Met Gln 
785                 790                 795                 800 


Thr Ser Thr Arg Phe Leu Gly Leu Ile Cys Cys Leu Leu Gly Tyr Ala 
                805                 810                 815     


Ile Leu Leu Gln Ile Ser Lys Asp 
            820                 


<210>  8708
<211>  965
<212>  DNA
<213>  Homosapiens

<400>  8708
ggtgttacct gggccaggtg gggaaggttt gtttgcagag caaagaagtg aaggaagtat     60

taaccctttg catggcctcc tgagaatccg acaagacgta aatagccaag aatatctgtg    120

aaacttcatc actgagttac aatatttatc actgcaagtg tgttgttcat tgacactata    180

aagccatgtg gaattaagca gccttgaaac acaaaatgga gaaaggctaa gagctgagaa    240

ttgttgcctt cagggaaata caatcaatgt caagcaaaca accaccccaa aatggttagc    300

tttatcagca ttcaggccta cagtgaacgc aaatgttcca gatctgagtt tcaattttta    360

aagaataaac atatgcaaat gaccattagt cttagtagtt ttagggctca gaatgatctt    420

atcttgttaa cattcagggc aactgcttat acccatttga atgtcattta gagggctagg    480

aaagactgct tcaacatttg atgactaaat ggcagggctc agccacaatg ctcactccga    540

gaaatgagaa atagacacac cagtatgcta gatgctgatg cagttcagga aatgctaccc    600

caaaatatgg cccctcagca tactgagtat tttaagcaga aggcaattaa gaaaaccaca    660

aaaacagaaa ggtccctctg accttctccc accctctctc tcttgaagat cctcatgtga    720

caggtgacct gccatataat cagaaggaag aaatgttaca cagagaggct gagaagaatc    780

tgaggacttg ctaagttttc cccagtttat taccattaga tcatatgcct tttttgttca    840

atcatacttc tatacaactg tccatcattc attaaaccta accacaaaag tagttttcac    900

tcggtttttg agtgaaggct cctgtgtcac ataaaactta cattaaataa atttgttcca    960

ctttt                                                                965


<210>  8709
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  8709

Met Val Ser Phe Ile Ser Ile Gln Ala Tyr Ser Glu Arg Lys Cys Ser 
1               5                   10                  15      


Arg Ser Glu Phe Gln Phe Leu Lys Asn Lys His Met Gln Met Thr Ile 
            20                  25                  30          


Ser Leu Ser Ser Phe Arg Ala Gln Asn Asp Leu Ile Leu Leu Thr Phe 
        35                  40                  45              


Arg Ala Thr Ala Tyr Thr His Leu Asn Val Ile 
    50                  55                  


<210>  8710
<211>  208
<212>  DNA
<213>  Homosapiens

<400>  8710
aagcactgtg gattctgcct ctcagtgtcc agacacccat tttccttccc actgttcctt     60

ccccatggag aagcctgtgg ctggctgaca gcagagagag atgctcaact tggagaaggt    120

gttacctggg ccaggtgggg aaggtttgtt tgcagagcaa agaagtgaag atcctcatgt    180

gacaggtgac ctgccatata atcagaag                                       208


<210>  8711
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  8711

Met Leu Asn Leu Glu Lys Val Leu Pro Gly Pro Gly Gly Glu Gly Leu 
1               5                   10                  15      


Phe Ala Glu Gln Arg Ser Glu Asp Pro His Val Thr Gly Asp Leu Pro 
            20                  25                  30          


Tyr Asn Gln 
        35  


<210>  8712
<211>  385
<212>  DNA
<213>  Homosapiens

<400>  8712
tttggaaaag tataaaccta aggcatcacc tttacagaaa atatcttcca cggaaacatc     60

taaaggccac agatcagccc tggggttcag agggatcctg acagctactc ctcaagatcc    120

tctctgttgt gattcatccc cccggggccc tacagtttct ccttcctgac tcttacattt    180

ctttggatgg catcattatt tacctgtctc ctcccatagt taggtgccaa gcactgtgga    240

ttctgcctct cagtgtccag acacccattt tccttcccac tgttccttcc ccatggagaa    300

gcctgtggct ggctgacagc agagagagat gctcaacttg gagaaggtgt tacctgggcc    360

aggtggggaa ggtttgtttg cagag                                          385


<210>  8713
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  8713

Gln Leu Leu Leu Lys Ile Leu Ser Val Val Ile His Pro Pro Gly Ala 
1               5                   10                  15      


Leu Gln Phe Leu Leu Pro Asp Ser Tyr Ile Ser Leu Asp Gly Ile Ile 
            20                  25                  30          


Ile Tyr Leu Ser Pro Pro Ile Val Arg Cys Gln Ala Leu Trp Ile Leu 
        35                  40                  45              


Pro Leu Ser Val Gln Thr Pro Ile Phe Leu Pro Thr Val Pro Ser Pro 
    50                  55                  60                  


Trp Arg Ser Leu Trp Leu Ala Asp Ser Arg Glu Arg Cys Ser Thr Trp 
65                  70                  75                  80  


Arg Arg Cys Tyr Leu Gly Gln Val Gly Lys Val Cys Leu 
                85                  90              


<210>  8714
<211>  786
<212>  DNA
<213>  Homosapiens

<400>  8714
ccttccttcc tgccttcctt cttccttcct cccttttttc ttttctccct tccttccttc     60

ttaatatgtt tttggccttt tctttatata tgtggcctag caatatcctg tgtttggaaa    120

agtataaacc taaggcatca cctttacaga aaatatcttc cacggaaaca tctaaaggca    180

aaaatccttc aaattcaaat ttatccaatc atttcttctg cttactacca tcctaaatca    240

tttttcttta gtaagatcta ttagtgtgaa gctattaagc tattaatgta tgtatcatat    300

taatgtatta agacattaag tgaggaagta aagttgcatt cacaggcctt gaacttttcc    360

acatctcgat ttttacccat catctctgca tagttcccta aggcagcctt caaatggtga    420

tgtttcttat aatccagagt tcagaagtgg cttctcttca atctttctgt ggaattctaa    480

accacgtgat aaaggagctg gtggctggtc tcaaactcag gctcaaatga tccacccatc    540

ttggcctccc aaagtgttac gtgtgaacca ctgcacctgg ccaaaaatat tttactaaga    600

aaaaggagtc acctattgta tgattccatt tatatgaaat atccaaaata ggccacagat    660

cagccctggg gttcagaggg atcctgacag ctactcctca agatcctctc tgttgtgatt    720

catccccccg gggccctaca gtttctcctt cctgactctt acatttcttt ggatggcatc    780

attatt                                                               786


<210>  8715
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  8715

Met Val Met Phe Leu Ile Ile Gln Ser Ser Glu Val Ala Ser Leu Gln 
1               5                   10                  15      


Ser Phe Cys Gly Ile Leu Asn His Val Ile Lys Glu Leu Val Ala Gly 
            20                  25                  30          


Leu Lys Leu Arg Leu Lys 
        35              


<210>  8716
<211>  840
<212>  DNA
<213>  Homosapiens

<400>  8716
tctggggttc ttgagaaaaa tagagacact ctccctgccg atgtggttgt ggtcctgaga     60

acgtcagaaa acaagcttct tcagcagctc ttctcaatcc ctctgaccaa aacagctccc    120

actttccaga ctattgaaga gattaaaaag catgaggagt agaataagga ggcccaaggt    180

caccaggaga cagggctcct cccaggtttc tgcagccccc ttctgcttac acctggctgc    240

atctggctgt ggagctgcct gtgcctgaga ggcacactct cactgcaagg ttctcagtga    300

ccttgtggta aaaggaggca gccacagtca atatgaattc tctctgttct cttctcatgc    360

ttatgcagcc agccttttgc ctgcagatgg gccacttcag acatgatgaa atgttctttg    420

taatacttcc tattgatagg aaatcctctg aagattttag gtgtgaaaat ttgaagtagc    480

agcaacactg ctttctaacc cttcggctga gacttttcaa actgaatgat ctagatagaa    540

aaacattaaa aggaaggatg ttataacatg gtttcaaggc atattttcct gtttgggtaa    600

tgttccactt gcaactagta aactgagaga aaagcttaaa aggctcaggg gaagaaagaa    660

acagagtttc aaaaagaact tgaaaattca tttttgtctt tgaatcatga attctgactt    720

ccaaatagta gtttggggtg ttaaagaagt tatgaacttg ggagaaacta ggaaaaataa    780

gaatagcacc agagggaaca ttctctgaac ctcaaagttt gatttttgct tcagaaccta    840


<210>  8717
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  8717

Met Asn Ser Leu Cys Ser Leu Leu Met Leu Met Gln Pro Ala Phe Cys 
1               5                   10                  15      


Leu Gln Met Gly His Phe Arg His Asp Glu Met Phe Phe Val Ile Leu 
            20                  25                  30          


Pro Ile Asp Arg Lys Ser Ser Glu Asp Phe Arg Cys Glu Asn Leu Lys 
        35                  40                  45              


<210>  8718
<211>  453
<212>  DNA
<213>  Homosapiens

<400>  8718
caggtggtgg gccttttgat gacagctatg gaaaagtctt tccagaaaaa tgcacgtgca     60

cataaaatta gaatgtttcc aagatacgca tggaccctgt gaaacccact gaagattcca    120

tggccccagt ctttctcagg ctaacctctc aagctcttga aggttataag agggattgat    180

agtccatgat tcaggtcttg agataaaagg cacgaacgtc cctcccaagg ggaaaccatg    240

ttgtgagaga cccatgtatg gctgaactaa acctgtgtgc atgtgagtga agcagagcct    300

caagctccag atggatcttg agatggctgc agcctggctt gactgaaacc tcatggatga    360

cctcgagcca gaacaaccgg gctaaactgc ttccagattc ctgaccctca gaaacagtga    420

aataataaac gcttgttgtt ttaaactgct aaa                                 453


<210>  8719
<211>  630
<212>  DNA
<213>  Homosapiens

<400>  8719
agcttgtcca gagcatgctc atgtcttcat ccagccctgg aggtaccatt gtcttaaaga     60

aatctctgcg acagagtcaa catcatacac tctaagctct agagctatat tttgtaaaaa    120

caaaaaaggt ttccctgctt cactttgcct gcggaccccc ttctgatgaa ctccactcag    180

gccttgttcc tggagccctc ttcctctggc tgcaatccag agcaagttgc tgtctggact    240

tgttgaaaag ctgttgtcct gagacttctc ttcaaattct aaggaaaaat ttactttttc    300

tcaggattct aaacccaatc aaataatcaa gtgtaaaggc aaaatagata caaaatgtac    360

cttgcaaata ctctaggaag ctactggaag aaaggcttca gcaaataaag gaagtgtatg    420

aagaaagaaa gaagcatggc acattgctac cttaactaat aaaaatctct gaactttccg    480

gtcccatctg aggaagcaaa aatgctactt gctgcaaaaa cgacaccatt tatcacactg    540

caacaaaagc aatgtatagg catgccttgg ggatatgtga gtttgattcc agactacttc    600

aataaaatga atactgcaat gaagtcacac                                     630


<210>  8720
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  8720

Met Leu Leu Ala Ala Lys Thr Thr Pro Phe Ile Thr Leu Gln Gln Lys 
1               5                   10                  15      


Gln Cys Ile Gly Met Pro Trp Gly Tyr Val Ser Leu Ile Pro Asp Tyr 
            20                  25                  30          


Phe Asn Lys Met Asn Thr Ala Met Lys Ser 
        35                  40          


<210>  8721
<211>  653
<212>  DNA
<213>  Homosapiens

<400>  8721
cctgagaatg tttcaaggtc accaaaagct ttctgaaaat gcctttctgc aaagaaggtt     60

tccaggtacc attgtcttaa agaaatctct gcgacagagt caacatcata cactctaagc    120

tctagagcta tattttgtaa aaacaaaaaa ggtttccctg cttcactttg cctgcggacc    180

cccttctgat gaactccact caggccttgt tcctggagcc ctcttcctct ggctgcaatc    240

cagagcaagt tgctgtctgg acttgttgaa aagctgttgt cctgagactt ctcttcaaat    300

tctaaggaaa aatttacttt ttctcaggat tctaaaccca atcaaataat caagtgtaaa    360

ggcaaaatag atacaaaatg taccttgcaa atactctagg aagctactgg aagaaaggct    420

tcagcaaata aaggaagtgt atgaagaaag aaagaagcat ggcacattgc taccttaact    480

aataaaaatc tctgaacttt ccggtcccat ctgaggaagc aaaaatgcta cttgctgcaa    540

aaacgacacc atttatcaca ctgcaacaaa agcaatgtat aggcatgcct tggggatatg    600

tgagtttgat tccagactac ttcaataaaa tgaatactgc aatgaagtca cac           653


<210>  8722
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  8722

Met Phe Gln Gly His Gln Lys Leu Ser Glu Asn Ala Phe Leu Gln Arg 
1               5                   10                  15      


Arg Phe Pro Gly Thr Ile Val Leu Lys Lys Ser Leu Arg Gln Ser Gln 
            20                  25                  30          


His His Thr Leu 
        35      


<210>  8723
<211>  4619
<212>  DNA
<213>  Homosapiens

<400>  8723
cctgtctccc ggacgaggac ctcaacccct tcccccgctc ggggaccccg gccacccgca     60

gcccggccgc gctgcgccca gaaacccatg agtcttcctc agcagctgtc gaaacttgcc    120

ggcggttgct tgctcacctt tgctgtctcc ccttcagaaa aggctggagg ggagggcgag    180

gaaggcttgg cgtggggacg cccgtcgagt ctctcagtga ggaatgagag gccagcttct    240

cctgcggggt atgaaggagg aactgtatct cctatatata ttaagtttca tttataaaga    300

catcagagag cacctgagaa tgtttcaagg tcaccaaaag ctttctgaaa atgcctttct    360

gcaaagaagg tttccagaga tagaagataa ctcaggaagc ttagaagagg tcaacctggg    420

aagacaggat tctttctccc cacccgtggc tctgcaggaa gcaataccct cccctctggg    480

caaggtcgac cctccaagtc cagatgagaa gagttccctc tgtctgctct ttcctctgcc    540

tgatgaccca gaggctttgc agctgtgatc ctggcagccc ctggccacct cagggagctg    600

cagaattcaa accctggaaa tggagctctg cttgcagctg cacctggggc ctgacctgct    660

taggacaggc ctgtctggac ctaagagaac cccactgcca cccactcagc tactccctaa    720

cagactgcag agaccaagtc tttttcattt ctttatatcc attgatttct cgagttattg    780

aaactcaata tttactgagc acctacaatg tgccaggcac tgtgataggc actgaagaaa    840

gggcaaagga cgagcagata aatttcctac ttgcagggaa caccgtggta gtgagtaaaa    900

tgagacattg caaataaaca cataaatata taatatgtca actggcaata attgatgcga    960

agaatgatta agcaaaacaa ggaaatgcag agacagggaa ggagcatcta tctggtatga   1020

agtagtcaga gaaggcctct ctggtcagat gacatttggg cagaacctgg ggcctgtctc   1080

agcaccacct gttccttcct cggccacttg ctccctgcag ccaccaaagg cccctgtggt   1140

tttcccgcct gaggctcacc agccacaggc ctagaatatc tggcttctct ccccacgtcc   1200

aaactcagct gaaatgccaa actgcaggac cttgtttcct gagcaactgc caatggggct   1260

gaatgatgca actcggaaag gaagaggatt tcattccccc tgaatggact ttgcaccagt   1320

gggagacagg aaacaggaga ttggaggata ctgggcagct gaactgcctc accctttccc   1380

cctgccccgt ctggtgcaca atttctccac acagcctgct gtgtgtggcc aagcctgtgc   1440

gccgactgag tgttatgggt tgaactatgt tcctcagaaa gatatgtcga agtcctaacc   1500

cccagtaact gtgaatgtgg ctttatagta tttggaaaca gggtctttgc tgatgcaatc   1560

aagttaagat gaagtcatta agggggtagg ggcctaatcc aatctcttgt ccttagaagg   1620

agaaagacag agacacatca ggggaagatg gtgaggtgac aatggaggca gagattggag   1680

caatttatct aaatgctagg caacgccaca gagagctgca aacaccaagg ctagaagagg   1740

cagggaagga gcctccccta caggtttcag agggagcatg gcctcaccat acctttactt   1800

cagacttcta gcatccagaa ctgtgacaca acacatttct gttgttctga gtgacaacag   1860

tgtgtggtgt gttattacag ctgctctaga aactaacata tcgagcagcc agctgtgtgg   1920

gattgtacct cccaagtaac cctctaagac ttaacctttg cccagggctc tgtctctaga   1980

gaactgtgac aatgataggt agacctgaat aaagcgaagg atgatatctg cagggatatt   2040

tgaggacagg gagtgctgac aagggaggag ccagtgcaaa ggccccgagg tggcagtatg   2100

cttggtgtgt tggaggagca ggaaggtgac cagggtgttt ggggagtgaa taaggggaag   2160

agtgctcaga ggagaagtca gaggaggggc caaagacatg ttctctaggg ccagaaaggc   2220

ctttggatct tttcgacatt atcttcttga catgtaattt atatagtagt aaaatgaaca   2280

aaatgggtga ctattttgtg aattttttag atacataaaa ccacgtgatc actatccaga   2340

tcaaatgttg aacatttcca tcaccccaga gagttcactc ctgctacctt ccagtcaata   2400

caacttacca atcctgaggc aaccagtact ctctctttta tcatcataaa tttgttttaa   2460

cctgttcctt aatggcatat aaatgaaact acatagcatg cttttgctca aaatagtgct   2520

tgtgaggttc atccaggttg ctgtatgtat acttcaatta ttattattgc tgagtagtat   2580

tccattgcct ggatatatca caaattattt atccattctt ctgctgaata tttgagttat   2640

ttgcagttta ggcctataat aaatgaagcc gctaggaaca tttatgtgtt cctcttattt   2700

tggttgcatg caatcatttc tcttggtata aacctagcag tgtattttct gggtcaactg   2760

gcttaggttt aggttaactg tattcgttta caccatttta tactcccgtc agcaatatat   2820

gagttccagg tattctgcat cctcaccaac acttggagcc tttctggtag gtgtgtagtg   2880

gcattgcatt gtgctttcaa tatgcatttt tctgctgact aatgcactcc tttttatatg   2940

cctattattc acatatctcc ttttatgaag taggtattca agtcttttat tcacatttta   3000

tgttttgtta tggccacatc tcacttccag aatctgtatt ggttatctat cgcgcattaa   3060

aaaagtactc taaagcttga cagctaaaaa caacaaacat tcattctctc acacagtctc   3120

tgcaggtcag gaacctgggt gcagcttcat ggggtggttc tggctcaggg tctcaggttg   3180

catttgagct gctgtctgag gttacagccc tacctatcaa agctgaacca gagccagact   3240

ccatgtctaa actcacttat gtgagcttca gtgtgagaaa tgtatgaatt ttgtttgatg   3300

aaatattgaa aagcttaaca acttcctcct actctcattg gcctcttggt gcccagtatc   3360

tgagtctgaa aaatctcatc tataggaatc aatggcagca aagacagaac caaggtccca   3420

cggctattgg ggaggttggc agatgagtga ggaaaaaggg gtgtcagcaa tctaaaaata   3480

ttcaggctca cagaaatata actgtttgaa atgactcact tttattaaga tcctgccatc   3540

tcacttacca gcttaaaaaa aaatagatca cagcagaatg tttcaaattc tccataaatg   3600

gccatttgat ccagcaacct acctgtggaa atttatgcca agattagaat ctacaaaata   3660

catacagaga tgcacattga agtattattt attaggaatc taaattgtgg aatcattaaa   3720

gagaatacat attccctcaa aagaatacca tggtgttatt aaaagtagtc attatgagtg   3780

gttaggatat aatataatat tacaggaaat tcttaggata taccatcaag tagaaaaact   3840

tttcttccca gcttttcaat gtgaaaatgt ttaaacctac aggaaagttg taaggccaga   3900

acaataaatg cttgtatagc cttcatctag attctccaac agtgaccaca gttgccacat   3960

ctctttaagt gtaatgctca tcctttgaga gtaagtgcag acattttgat accatgctct   4020

aagtactaca acacctatct aaaattgtag aaggaaactc ttctatgatt ttcacactca   4080

agacatttaa cactgatata aagtttatat tcaaatttct ccaaaagatt taaaactatc   4140

tctttggctt gtgttatcca ggactcaatg gaggattgag cattgcattt agttgttgtg   4200

cctctttagt tttttttgat ctaaaacaat ccctcaacca tttttaaaaa ttctttcatg   4260

acattgacat ttttaaaaga ctctggaaca gtcattttac agaatatcct tcaatttgga   4320

tgtgtctgtt tcctcaagat tagaaattac atgaacttct tggctaactt ctccatttta   4380

ttttgtgttc aaaatatatt actctttccc atgtcctgtg aaaataaaaa atctctaatg   4440

tgtttgtgaa aaagattaag ctaagatttt gtttggatgc agtgtgattt ggacttaggt   4500

gtgtgtatct gaacttcatc ctttgtcatc aaaagaatag tataataact aagaacatgt   4560

agcttaagaa atccaggcac ttgagagcca ctgtaagtaa actctaattc ccacagcag    4619


<210>  8724
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  8724

Met Arg Gly Gln Leu Leu Leu Arg Gly Met Lys Glu Glu Leu Tyr Leu 
1               5                   10                  15      


Leu Tyr Ile Leu Ser Phe Ile Tyr Lys Asp Ile Arg Glu His Leu Arg 
            20                  25                  30          


Met Phe Gln Gly His Gln Lys Leu Ser Glu Asn Ala Phe Leu Gln Arg 
        35                  40                  45              


Arg Phe Pro Glu Ile Glu Asp Asn Ser Gly Ser Leu Glu Glu Val Asn 
    50                  55                  60                  


Leu Gly Arg Gln Asp Ser Phe Ser Pro Pro Val Ala Leu Gln Glu Ala 
65                  70                  75                  80  


Ile Pro Ser Pro Leu Gly Lys Val Asp Pro Pro Ser Pro Asp Glu Lys 
                85                  90                  95      


Ser Ser Leu Cys Leu Leu Phe Pro Leu Pro Asp Asp Pro Glu Ala Leu 
            100                 105                 110         


Gln Leu 
        


<210>  8725
<211>  449
<212>  DNA
<213>  Homosapiens

<400>  8725
aatgctacta aaatggctgc tgcctctctg tttccttaga aacccatgag tcttcctcag     60

cagctgtcga aacttgccgg cggttgcttg ctcacctttg ctgtctcccc ttcagaaaag    120

gctggagggg agggcgagga aggcttggcg tggggacgcc cgtcgagtct ctcagtgagg    180

aatgagaggc cagcttctcc tgcggggtat gaaggaggaa ctgtatctcc tatatatatt    240

aagtttcatt tataaagaca tcagagagca cctgagaatg tttcaaggtc accaaaagct    300

ttctgaaaat gcctttctgc aaagaaggtt tccagtactt tcagggagag tgttaattgg    360

attggaagga agacactgat gagctgctgg gagtgagagt gagaccctcg aggagtccac    420

agtgcatttt aaggagtgta gctctgatg                                      449


<210>  8726
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  8726

Met Ser Leu Pro Gln Gln Leu Ser Lys Leu Ala Gly Gly Cys Leu Leu 
1               5                   10                  15      


Thr Phe Ala Val Ser Pro Ser Glu Lys Ala Gly Gly Glu Gly Glu Glu 
            20                  25                  30          


Gly Leu Ala Trp Gly Arg Pro Ser Ser Leu Ser Val Arg Asn Glu Arg 
        35                  40                  45              


Pro Ala Ser Pro Ala Gly Tyr Glu Gly Gly Thr Val Ser Pro Ile Tyr 
    50                  55                  60                  


Ile Lys Phe His Leu 
65                  


<210>  8727
<211>  4311
<212>  DNA
<213>  Homosapiens

<400>  8727
gcggggaggg cgggcctgtc gcagccgcgc tggtcgccag gcgtccggga ggagcggggt     60

ccgcgcggcg gacgaggcgg gggcggaggc gcaggcagag cgagcgcggg aggtcgccgc    120

agccagggac accgcgcgcc gccgctcaac atggtcgctg cgcacgctgc ccattcttcc    180

tcctctgccg agtggatcgc ctgcctggat aaaagaccac tggagcgatc cagcgaagat    240

gtggatataa tcttcactcg actgaaagaa gttaaagctt ttgagaaatt tcacccaaat    300

ctccttcatc agatttgctt atgtggttat tatgagaatc tggaaaaggg aataacatta    360

tttcgccagg gtgatattgg aacaaactgg tatgctgtcc tggcagggtc tttggatgtt    420

aaagtatctg agaccagcag tcaccaggat gctgtgacca tctgtaccct gggaattggg    480

acggcctttg gagagtccat tctggacaac acaccccgcc atgcaaccat cgttaccagg    540

gagagcagtg aactgctccg catcgagcag aaggacttca aggcactatg ggagaaatat    600

cgacagtata tggcaggact tctggctcct ccttatggtg ttatggaaac gggctctaac    660

aatgacagga ttcctgacaa ggagaacaca cctctcattg aacctcacgt tcctcttcgt    720

cctgctaaca ccattaccaa ggtcccttca gagaagatcc tcagagctgg aaaaatttta    780

cgaaatgcca ttctctctcg agcacctcac atgataagag atagaaaata ccacctaaag    840

acatacagac aatgctgtgt gggaactgaa ctggtggact ggatgatgca gcagacacca    900

tgtgttcact cccggactca agctgttggc atgtggcaag tcctgttaga agatggtgtt    960

ctcaaccacg tggaccagga gcaccatttc caagacaaat atttattcta tcgatttctg   1020

gatgatgagc acgaggatgc ccctttgcct actgaggagg agaagaagga gtgtgatgag   1080

gagctccagg acaccatgct gctgctgtca cagatgggcc ccgacgccca catgaggatg   1140

atccttcgca aaccacctgg ccagaggact gtggatgacc tagagattat ctatgaggag   1200

cttcttcata ttaaagcctt atcccatctt tctaccacag tgaaacgaga gttagcaggt   1260

gttctcattt ttgagtctca cgccaaagga gggactgtgt tgtttaacca gggggaagaa   1320

ggtacctcct ggtacattat tctaaaagga tcagtgaatg tagtcattta cggcaagggt   1380

gtggtctgca ccctgcatga aggagatgac ttcggcaagt tagcactagt gaatgatgcc   1440

ccacgagctg cctctatcgt cttacgagaa gataactgcc atttcttaag agtagacaag   1500

gaggatttca accggatcct aagggacgtg gaggcgaata cagtcagact taaagaacat   1560

gaccaagatg tcttggtgct ggagaaggtc ccagcaggga acagagcttc taatcaagga   1620

aactcacagc ctcagcaaaa gtatactgtg atgtcaggaa cacctgaaaa aattttagag   1680

cattttctag aaacaatacg ccttgaggca actttaaatg aagcaacaga ttctgtttta   1740

aatgacttta ttatgatgca ctgtgttttt atgccaaata cccagctttg cccggcactg   1800

gtggcaccta ccacgcacag ccttcacaag gtacagaaca ggagaaaatg gattatgccc   1860

tcaacaataa gaggcgagtc atccgcctgg ttctacagtg ggctgccatg tatggagacc   1920

tcctgcaaga ggatgacgtg tctatggcct tcctggagga gttttatgta tctgtatcag   1980

atgatgcccg gatgattgct gccctcaagg agcaactgcc agagttggag aagattgtca   2040

agcaaatctc agaagatgca aaggcaccac aaaagaagca caaggttctt ttgcaacagt   2100

tcaatacggg cgatgagaga gcccagaagc gccagcctat ccgcggctct gatgaagttc   2160

tgtttaaggt ctattgcatg gaccacacct acacaaccat tcgggtgcca gtggccactt   2220

cggtgaagga agtcatcagt gcagttgccg acaagctggg ctccggggag ggcctgatca   2280

tagtcaagat gagttccgga ggagaaaagg tggtgctcaa acctaatgat gtttcagtat   2340

ttacgacgct caccattaat ggacgcctgt ttgcttgccc gcgagagcaa ttcgattcac   2400

tgactccctt accagaacag gaaggcccaa ctgttggaac agtgggaact tttgaactga   2460

tgagctccaa agatttagca taccagatga caatttatga ttgggaactc ttcaactgcg   2520

tgcatgagct ggagctaatc tatcacacat ttggaaggca taattttaaa aagaccacag   2580

caaacttgga tttgttcctg aggagattta atgaaattca gttttgggtc gtcactgaga   2640

tctgcctttg ttctcagctc agcaagcgtg ttcagctatt aaaaaaattt attaagatag   2700

cagcccactg taaggagtat aaaaatctga attccttttt tgccatcgtc atgggactaa   2760

gtaacgttgc tgtgagccgc ttggcactaa cgtgggagaa actgccaagc aagttcaaga   2820

agttctatgc ggagtttgaa agtttaatgg acccttcaag gaaccacagg gcctacaggc   2880

tgacagtagc taagctggaa cctcctctca tccccttcat gcctttgctc attaaagata   2940

tgacatttac tcatgagggg aacaagacgt tcattgacaa tctagtaaac tttgaaaaaa   3000

tgcgcatgat tgcaaatacg gccagaacag tgagatacta caggagccaa cccttcaatc   3060

ctgatgcagc tcaagctaat aagaaccatc aggatgtccg gagttatgta cggcaattaa   3120

atgtgattga caaccagaga actttatcac agatgtcaca cagattagag cctcgtcgac   3180

catagacatt tcaaatgccc aaagcaacag tttgtctcca gtccacaatc tttcaaaaat   3240

gccatttatg ctactactga ctgtattgcc actagagaat tctacaaaac aagcaaaaac   3300

acatcctgag acacctcagg gctgcattca gcttaccagc tacctagcaa gagaaggaat   3360

tatttgacat gcctaaagct tacacactct agcttaggaa tccccagttt gtggctaccc   3420

tgtttcattt ccacttgtgc catcttcttt gctgaagtgt tgaataaggc ccacgtgaag   3480

agtttggtag aaatagcctt gtcaagagaa ctagcaagcc cctgacattt ttttctaaga   3540

gtgtttatgg gatgagatgt gctacaaatg ggatagattt ggataaaatt ttaactcaac   3600

atcttgattt ggagcctggg gtttcgggaa ggtgttgagg aatctataga agtccaaatt   3660

ataggttgta ttcttccatc ttcattgtct tacctctgaa ggaatagaac ctgaccacat   3720

tattatgaaa cattatggct gtttatgtaa tttagggagg actggtctgt aatttctgaa   3780

tgtatataga ataatattta tgtttacaat gtaacttttc aaaatttaca aatcaggatt   3840

atatacataa gaattccact aagaaatgcc aagattctta aatttgccag cgttaaagta   3900

gaaaataaca tttcagaaga gcacaatatg cataaaacat ttttcaaaat tgaaatattt   3960

tcctgggcat taaaaacctt tactattggc tacaaattta ttgtacctga tgaaaacata   4020

ttttctggac ttaaatgtta ttacaaatat cttaattttc agtaattgtt ttgcactttc   4080

aaagattgta aatagttcat tcaatcaatg gtatggagtt atttatttgc tacataatag   4140

atactgtgcc aaataattac tttttattta ttttatttag tacgtaattt tgaagtacat   4200

tttttcctgt tttcacaatt agactacatt taatgtgtag gaattgtatg tatgtatatc   4260

ttctgtaaat aacatctagt atcttcacta aatataattg tcgacaagaa a            4311


<210>  8728
<211>  614
<212>  PRT
<213>  Homosapiens

<400>  8728

Met Val Ala Ala His Ala Ala His Ser Ser Ser Ser Ala Glu Trp Ile 
1               5                   10                  15      


Ala Cys Leu Asp Lys Arg Pro Leu Glu Arg Ser Ser Glu Asp Val Asp 
            20                  25                  30          


Ile Ile Phe Thr Arg Leu Lys Glu Val Lys Ala Phe Glu Lys Phe His 
        35                  40                  45              


Pro Asn Leu Leu His Gln Ile Cys Leu Cys Gly Tyr Tyr Glu Asn Leu 
    50                  55                  60                  


Glu Lys Gly Ile Thr Leu Phe Arg Gln Gly Asp Ile Gly Thr Asn Trp 
65                  70                  75                  80  


Tyr Ala Val Leu Ala Gly Ser Leu Asp Val Lys Val Ser Glu Thr Ser 
                85                  90                  95      


Ser His Gln Asp Ala Val Thr Ile Cys Thr Leu Gly Ile Gly Thr Ala 
            100                 105                 110         


Phe Gly Glu Ser Ile Leu Asp Asn Thr Pro Arg His Ala Thr Ile Val 
        115                 120                 125             


Thr Arg Glu Ser Ser Glu Leu Leu Arg Ile Glu Gln Lys Asp Phe Lys 
    130                 135                 140                 


Ala Leu Trp Glu Lys Tyr Arg Gln Tyr Met Ala Gly Leu Leu Ala Pro 
145                 150                 155                 160 


Pro Tyr Gly Val Met Glu Thr Gly Ser Asn Asn Asp Arg Ile Pro Asp 
                165                 170                 175     


Lys Glu Asn Thr Pro Leu Ile Glu Pro His Val Pro Leu Arg Pro Ala 
            180                 185                 190         


Asn Thr Ile Thr Lys Val Pro Ser Glu Lys Ile Leu Arg Ala Gly Lys 
        195                 200                 205             


Ile Leu Arg Asn Ala Ile Leu Ser Arg Ala Pro His Met Ile Arg Asp 
    210                 215                 220                 


Arg Lys Tyr His Leu Lys Thr Tyr Arg Gln Cys Cys Val Gly Thr Glu 
225                 230                 235                 240 


Leu Val Asp Trp Met Met Gln Gln Thr Pro Cys Val His Ser Arg Thr 
                245                 250                 255     


Gln Ala Val Gly Met Trp Gln Val Leu Leu Glu Asp Gly Val Leu Asn 
            260                 265                 270         


His Val Asp Gln Glu His His Phe Gln Asp Lys Tyr Leu Phe Tyr Arg 
        275                 280                 285             


Phe Leu Asp Asp Glu His Glu Asp Ala Pro Leu Pro Thr Glu Glu Glu 
    290                 295                 300                 


Lys Lys Glu Cys Asp Glu Glu Leu Gln Asp Thr Met Leu Leu Leu Ser 
305                 310                 315                 320 


Gln Met Gly Pro Asp Ala His Met Arg Met Ile Leu Arg Lys Pro Pro 
                325                 330                 335     


Gly Gln Arg Thr Val Asp Asp Leu Glu Ile Ile Tyr Glu Glu Leu Leu 
            340                 345                 350         


His Ile Lys Ala Leu Ser His Leu Ser Thr Thr Val Lys Arg Glu Leu 
        355                 360                 365             


Ala Gly Val Leu Ile Phe Glu Ser His Ala Lys Gly Gly Thr Val Leu 
    370                 375                 380                 


Phe Asn Gln Gly Glu Glu Gly Thr Ser Trp Tyr Ile Ile Leu Lys Gly 
385                 390                 395                 400 


Ser Val Asn Val Val Ile Tyr Gly Lys Gly Val Val Cys Thr Leu His 
                405                 410                 415     


Glu Gly Asp Asp Phe Gly Lys Leu Ala Leu Val Asn Asp Ala Pro Arg 
            420                 425                 430         


Ala Ala Ser Ile Val Leu Arg Glu Asp Asn Cys His Phe Leu Arg Val 
        435                 440                 445             


Asp Lys Glu Asp Phe Asn Arg Ile Leu Arg Asp Val Glu Ala Asn Thr 
    450                 455                 460                 


Val Arg Leu Lys Glu His Asp Gln Asp Val Leu Val Leu Glu Lys Val 
465                 470                 475                 480 


Pro Ala Gly Asn Arg Ala Ser Asn Gln Gly Asn Ser Gln Pro Gln Gln 
                485                 490                 495     


Lys Tyr Thr Val Met Ser Gly Thr Pro Glu Lys Ile Leu Glu His Phe 
            500                 505                 510         


Leu Glu Thr Ile Arg Leu Glu Ala Thr Leu Asn Glu Ala Thr Asp Ser 
        515                 520                 525             


Val Leu Asn Asp Phe Ile Met Met His Cys Val Phe Met Pro Asn Thr 
    530                 535                 540                 


Gln Leu Cys Pro Ala Leu Val Ala Pro Thr Thr His Ser Leu His Lys 
545                 550                 555                 560 


Val Gln Asn Arg Arg Lys Trp Ile Met Pro Ser Thr Ile Arg Gly Glu 
                565                 570                 575     


Ser Ser Ala Trp Phe Tyr Ser Gly Leu Pro Cys Met Glu Thr Ser Cys 
            580                 585                 590         


Lys Arg Met Thr Cys Leu Trp Pro Ser Trp Arg Ser Phe Met Tyr Leu 
        595                 600                 605             


Tyr Gln Met Met Pro Gly 
    610                 


<210>  8729
<211>  4107
<212>  DNA
<213>  Homosapiens

<400>  8729
cttttaaacc aagcggaagc ctgcttcgat gacttggact tatgtctgca ccagggtctc     60

attcctgtgt cttcaagctt ttccatggag tggcaaaatg attcaaatcc agaaaggaag    120

ggagtgaagt tattaggagc taactaaagt taaaaaaaaa aaaaaaaaaa aaaaaggaag    180

tgttttctta ttgccttaga ctgcctgagc tttcctggag aaccatcagc accagtttcc    240

tttctgtgga ctgagagcca ctcagtagta gacacgaaca gggaatgaac ggcaatgaag    300

gtacattttg ctgatcaaat aaaggataga tgctcactgg atgtctgaga actttgagag    360

accgaaaaag aaggacgtat gctctacaag aaatatcgac agtatatggc aggacttctg    420

gctcctcctt atggtgttat ggaaacgggc tctaacaatg acaggattcc tgacaaggag    480

aacacacctc tcattgaacc tcacgttcct cttcgtcctg ctaacaccat taccaaggtc    540

ccttcagaga agatcctcag agctggaaaa attttacgaa atgccattct ctctcgagca    600

cctcacatga taagagatag aaaataccac ctaaagacat acagacaatg ctgtgtggga    660

actgaactgg tggactggat gatgcagcag acaccatgtg ttcactcccg gactcaagct    720

gttggcatgt ggcaagtcct gttagaagat ggtgttctca accacgtgga ccaggagcac    780

catttccaag acaaatattt attctatcga tttctggatg atgagcacga ggatgcccct    840

ttgcctactg aggaggagaa gaaggagtgt gatgaggagc tccaggacac catgctgctg    900

ctgtcacaga tgggccccga cgcccacatg aggatgatcc ttcgcaaacc acctggccag    960

aggactgtgg atgacctaga gattatctat gaggagcttc ttcatattaa agccttatcc   1020

catctttcta ccacagtgaa acgagagtta gcaggtgttc tcatttttga gtctcacgcc   1080

aaaggaggga ctgtgttgtt taaccagggg gaagaaggta cctcctggta cattattcta   1140

aaaggatcag tgaatgtagt catttacggc aagggtgtgg tctgcaccct gcatgaagga   1200

gatgacttcg gcaagttagc actagtgaat gatgccccac gagctgcctc tatcgtctta   1260

cgagaagata actgccattt cttaagagta gacaaggagg atttcaaccg gatcctaagg   1320

gacgtggagg cgaatacagt cagacttaaa gaacatgacc aagatgtctt ggtgctggag   1380

aaggtcccag cagggaacag agcttctaat caaggaaact cacagcctca gcaaaagtat   1440

actgtgatgt caggaacacc tgaaaaaatt ttagagcatt ttctagaaac aatacgcctt   1500

gaggcaactt taaatgaagc aacagattct gttttaaatg actttattat gatgcactgt   1560

gtttttatgc caaataccca gctttgcccg gcactggtgg cacctaccac gcacagcctt   1620

cacaaggtac agaacaggag aaaatggatt atgccctcaa caataagagg cgagtcatcc   1680

gcctggttct acagtgggct gccatgtatg gagacctcct gcaagaggat gacgtgtcta   1740

tggccttcct ggaggagttt tatgtatctg tatcagatga tgcccggatg attgctgccc   1800

tcaaggagca actgccagag ttggagaaga ttgtcaagca aatctcagaa gatgcaaagg   1860

caccacaaaa gaagcacaag gttcttttgc aacagttcaa tacgggcgat gagagagccc   1920

agaagcgcca gcctatccgc ggctctgatg aagttctgtt taaggtctat tgcatggacc   1980

acacctacac aaccattcgg gtgccagtgg ccacttcggt gaaggaagtc atcagtgcag   2040

ttgccgacaa gctgggctcc ggggagggcc tgatcatagt caagatgagt tccggaggag   2100

aaaaggtggt gctcaaacct aatgatgttt cagtatttac gacgctcacc attaatggac   2160

gcctgtttgc ttgcccgcga gagcaattcg attcactgac tcccttacca gaacaggaag   2220

gcccaactgt tggaacagtg ggaacttttg aactgatgag ctccaaagat ttagcatacc   2280

agatgacaat ttatgattgg gaactcttca actgcgtgca tgagctggag ctaatctatc   2340

acacatttgg aaggcataat tttaaaaaga ccacagcaaa cttggatttg ttcctgagga   2400

gatttaatga aattcagttt tgggtcgtca ctgagatctg cctttgttct cagctcagca   2460

agcgtgttca gctattaaaa aaatttatta agatagcagc ccactgtaag gagtataaaa   2520

atctgaattc cttttttgcc atcgtcatgg gactaagtaa cgttgctgtg agccgcttgg   2580

cactaacgtg ggagaaactg ccaagcaagt tcaagaagtt ctatgcggag tttgaaagtt   2640

taatggaccc ttcaaggaac cacagggcct acaggctgac agtagctaag ctggaacctc   2700

ctctcatccc cttcatgcct ttgctcatta aagatatgac atttactcat gaggggaaca   2760

agacgttcat tgacaatcta gtaaactttg aaaaaatgcg catgattgca aatacggcca   2820

gaacagtgag atactacagg agccaaccct tcaatcctga tgcagctcaa gctaataaga   2880

accatcagga tgtccggagt tatgtacggc aattaaatgt gattgacaac cagagaactt   2940

tatcacagat gtcacacaga ttagagcctc gtcgaccata gacatttcaa atgcccaaag   3000

caacagtttg tctccagtcc acaatctttc aaaaatgcca tttatgctac tactgactgt   3060

attgccacta gagaattcta caaaacaagc aaaaacacat cctgagacac ctcagggctg   3120

cattcagctt accagctacc tagcaagaga aggaattatt tgacatgcct aaagcttaca   3180

cactctagct taggaatccc cagtttgtgg ctaccctgtt tcatttccac ttgtgccatc   3240

ttctttgctg aagtgttgaa taaggcccac gtgaagagtt tggtagaaat agccttgtca   3300

agagaactag caagcccctg acattttttt ctaagagtgt ttatgggatg agatgtgcta   3360

caaatgggat agatttggat aaaattttaa ctcaacatct tgatttggag cctggggttt   3420

cgggaaggtg ttgaggaatc tatagaagtc caaattatag gttgtattct tccatcttca   3480

ttgtcttacc tctgaaggaa tagaacctga ccacattatt atgaaacatt atggctgttt   3540

atgtaattta gggaggactg gtctgtaatt tctgaatgta tatagaataa tatttatgtt   3600

tacaatgtaa cttttcaaaa tttacaaatc aggattatat acataagaat tccactaaga   3660

aatgccaaga ttcttaaatt tgccagcgtt aaagtagaaa ataacatttc agaagagcac   3720

aatatgcata aaacattttt caaaattgaa atattttcct gggcattaaa aacctttact   3780

attggctaca aatttattgt acctgatgaa aacatatttt ctggacttaa atgttattac   3840

aaatatctta attttcagta attgttttgc actttcaaag attgtaaata gttcattcaa   3900

tcaatggtat ggagttattt atttgctaca taatagatac tgtgccaaat aattactttt   3960

tatttatttt atttagtacg taattttgaa gtacattttt tcctgttttc acaattagac   4020

tacatttaat gtgtaggaat tgtatgtatg tatatcttct gtaaataaca tctagtatct   4080

tcactaaata taattgtcga caagaaa                                       4107


<210>  8730
<211>  470
<212>  PRT
<213>  Homosapiens

<400>  8730

Met Leu Tyr Lys Lys Tyr Arg Gln Tyr Met Ala Gly Leu Leu Ala Pro 
1               5                   10                  15      


Pro Tyr Gly Val Met Glu Thr Gly Ser Asn Asn Asp Arg Ile Pro Asp 
            20                  25                  30          


Lys Glu Asn Thr Pro Leu Ile Glu Pro His Val Pro Leu Arg Pro Ala 
        35                  40                  45              


Asn Thr Ile Thr Lys Val Pro Ser Glu Lys Ile Leu Arg Ala Gly Lys 
    50                  55                  60                  


Ile Leu Arg Asn Ala Ile Leu Ser Arg Ala Pro His Met Ile Arg Asp 
65                  70                  75                  80  


Arg Lys Tyr His Leu Lys Thr Tyr Arg Gln Cys Cys Val Gly Thr Glu 
                85                  90                  95      


Leu Val Asp Trp Met Met Gln Gln Thr Pro Cys Val His Ser Arg Thr 
            100                 105                 110         


Gln Ala Val Gly Met Trp Gln Val Leu Leu Glu Asp Gly Val Leu Asn 
        115                 120                 125             


His Val Asp Gln Glu His His Phe Gln Asp Lys Tyr Leu Phe Tyr Arg 
    130                 135                 140                 


Phe Leu Asp Asp Glu His Glu Asp Ala Pro Leu Pro Thr Glu Glu Glu 
145                 150                 155                 160 


Lys Lys Glu Cys Asp Glu Glu Leu Gln Asp Thr Met Leu Leu Leu Ser 
                165                 170                 175     


Gln Met Gly Pro Asp Ala His Met Arg Met Ile Leu Arg Lys Pro Pro 
            180                 185                 190         


Gly Gln Arg Thr Val Asp Asp Leu Glu Ile Ile Tyr Glu Glu Leu Leu 
        195                 200                 205             


His Ile Lys Ala Leu Ser His Leu Ser Thr Thr Val Lys Arg Glu Leu 
    210                 215                 220                 


Ala Gly Val Leu Ile Phe Glu Ser His Ala Lys Gly Gly Thr Val Leu 
225                 230                 235                 240 


Phe Asn Gln Gly Glu Glu Gly Thr Ser Trp Tyr Ile Ile Leu Lys Gly 
                245                 250                 255     


Ser Val Asn Val Val Ile Tyr Gly Lys Gly Val Val Cys Thr Leu His 
            260                 265                 270         


Glu Gly Asp Asp Phe Gly Lys Leu Ala Leu Val Asn Asp Ala Pro Arg 
        275                 280                 285             


Ala Ala Ser Ile Val Leu Arg Glu Asp Asn Cys His Phe Leu Arg Val 
    290                 295                 300                 


Asp Lys Glu Asp Phe Asn Arg Ile Leu Arg Asp Val Glu Ala Asn Thr 
305                 310                 315                 320 


Val Arg Leu Lys Glu His Asp Gln Asp Val Leu Val Leu Glu Lys Val 
                325                 330                 335     


Pro Ala Gly Asn Arg Ala Ser Asn Gln Gly Asn Ser Gln Pro Gln Gln 
            340                 345                 350         


Lys Tyr Thr Val Met Ser Gly Thr Pro Glu Lys Ile Leu Glu His Phe 
        355                 360                 365             


Leu Glu Thr Ile Arg Leu Glu Ala Thr Leu Asn Glu Ala Thr Asp Ser 
    370                 375                 380                 


Val Leu Asn Asp Phe Ile Met Met His Cys Val Phe Met Pro Asn Thr 
385                 390                 395                 400 


Gln Leu Cys Pro Ala Leu Val Ala Pro Thr Thr His Ser Leu His Lys 
                405                 410                 415     


Val Gln Asn Arg Arg Lys Trp Ile Met Pro Ser Thr Ile Arg Gly Glu 
            420                 425                 430         


Ser Ser Ala Trp Phe Tyr Ser Gly Leu Pro Cys Met Glu Thr Ser Cys 
        435                 440                 445             


Lys Arg Met Thr Cys Leu Trp Pro Ser Trp Arg Ser Phe Met Tyr Leu 
    450                 455                 460                 


Tyr Gln Met Met Pro Gly 
465                 470 


<210>  8731
<211>  1781
<212>  DNA
<213>  Homosapiens

<400>  8731
caaaaatgtg aaggtagaat attttgactt gctgttcagc caataaaatc tcatacctca     60

ttagtgagtc ttatttactg tgaggaactt gataagctaa cccttctcca catctaggat    120

agttacagat tctcttacaa attcatggca acctcaagaa aggatggtga aaaagcacta    180

atgtacagtc tcaggcatga tagatgtttt ttacatcatg gggaatatgc caacaattat    240

gagagttatg ccattaatat tccttacctg aaaatgcctt gtatgtatgt gggtacccct    300

ttgaaataat taaacaagtt atacatcagc tagttgcctt cagatagtca acatctcaga    360

acatgtcact tctcatggta ccaagtattg cagaaatggt ttgttttcct ttttggattg    420

tactctacgc ttacttgaat ttctatcttt cttttttcta tattcctttt agcgcatgat    480

tgcaaatacg gccagaacag tgagatacta caggagccaa cccttcaatc ctgatgcagc    540

tcaagctaat aagaaccatc aggatgtccg gagttatgta cggcaattaa atgtgattga    600

caaccagaga actttatcac agatgtcaca cagattagag cctcgtcgac catagacatt    660

tcaaatgccc aaagcaacag tttgtctcca gtccacaatc tttcaaaaat gccatttatg    720

ctactactga ctgtattgcc actagagaat tctacaaaac aagcaaaaac acatcctgag    780

acacctcagg gctgcattca gcttaccagc tacctagcaa gagaaggaat tatttgacat    840

gcctaaagct tacacactct agcttaggaa tccccagttt gtggctaccc tgtttcattt    900

ccacttgtgc catcttcttt gctgaagtgt tgaataaggc ccacgtgaag agtttggtag    960

aaatagcctt gtcaagagaa ctagcaagcc cctgacattt ttttctaaga gtgtttatgg   1020

gatgagatgt gctacaaatg ggatagattt ggataaaatt ttaactcaac atcttgattt   1080

ggagcctggg gtttcgggaa ggtgttgagg aatctataga agtccaaatt ataggttgta   1140

ttcttccatc ttcattgtct tacctctgaa ggaatagaac ctgaccacat tattatgaaa   1200

cattatggct gtttatgtaa tttagggagg actggtctgt aatttctgaa tgtatataga   1260

ataatattta tgtttacaat gtaacttttc aaaatttaca aatcaggatt atatacataa   1320

gaattccact aagaaatgcc aagattctta aatttgccag cgttaaagta gaaaataaca   1380

tttcagaaga gcacaatatg cataaaacat ttttcaaaat tgaaatattt tcctgggcat   1440

taaaaacctt tactattggc tacaaattta ttgtacctga tgaaaacata ttttctggac   1500

ttaaatgtta ttacaaatat cttaattttc agtaattgtt ttgcactttc aaagattgta   1560

aatagttcat tcaatcaatg gtatggagtt atttatttgc tacataatag atactgtgcc   1620

aaataattac tttttattta ttttatttag tacgtaattt tgaagtacat tttttcctgt   1680

tttcacaatt agactacatt taatgtgtag gaattgtatg tatgtatatc ttctgtaaat   1740

aacatctagt atcttcacta aatataattg tcgacaagaa a                       1781


<210>  8732
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  8732

Met Ile Ala Asn Thr Ala Arg Thr Val Arg Tyr Tyr Arg Ser Gln Pro 
1               5                   10                  15      


Phe Asn Pro Asp Ala Ala Gln Ala Asn Lys Asn His Gln Asp Val Arg 
            20                  25                  30          


Ser Tyr Val Arg Gln Leu Asn Val Ile Asp Asn Gln Arg Thr Leu Ser 
        35                  40                  45              


Gln Met Ser His Arg Leu Glu Pro Arg Arg Pro 
    50                  55                  


<210>  8733
<211>  7182
<212>  DNA
<213>  Homosapiens

<400>  8733
gactgtcttc ctcattggcg ccgtgcagag aggcggaatg ttcaactcct aactgcagcg     60

gaaacgtggg agccgcgcgg gccgctgtcg tcccaacccc cgccgccctc gtcgcgcgcg    120

gggcctccgc gcccccggct gctgctcacg ccccgcccgg gagccagatt ttgtggaagt    180

ataatacttt gtcattatga gatgtcgtct ctcggtgcct cctttgtgca aattaaattt    240

gatgacttgc agttttttga aaactgcggt ggaggaagtt ttgggagtgt ttatcgagcc    300

aaatggatat cacaggacaa ggaggtggct gtaaagaagc tcctcaaaat agagaaagag    360

gcagaaatac tcagtgtcct cagtcacaga aacatcatcc agttttatgg agtaattctt    420

gaacctccca actatggcat tgtcacagaa tatgcttctc tgggatcact ctatgattac    480

attaacagta acagaagtga ggagatggat atggatcaca ttatgacctg ggccactgat    540

gtagccaaag gaatgcatta tttacatatg gaggctcctg tcaaggtgat tcacagagac    600

ctcaagtcaa gaaacgttgt tatagctgct gatggagtat tgaagatctg tgactttggt    660

gcctctcggt tccataacca tacaacacac atgtccttgg ttggaacttt cccatggatg    720

gctccagaag ttatccagag tctccctgtg tcagaaactt gtgacacata ttcctatggt    780

gtggttctct gggagatgct aacaagggag gtccccttta aaggtttgga aggattacaa    840

gtagcttggc ttgtagtgga aaaaaacgag agattaacca ttccaagcag ttgccccaga    900

agttttgctg aactgttaca tcagtgttgg gaagctgatg ccaagaaacg gccatcattc    960

aagcaaatca tttcaatcct ggagtccatg tcaaatgaca cgagccttcc tgacaagtgt   1020

aactcattcc tacacaacaa ggcggagtgg aggtgcgaaa ttgaggcaac tcttgagagg   1080

ctaaagaaac tagagcgtga tctcagcttt aaggagcagg agcttaaaga acgagaaaga   1140

cgtttaaaga tgtgggagca aaagctgaca gagcagtcca acaccccgct tctcttgcct   1200

cttgctgcaa gaatgtctga ggagtcttac tttgaatcta aaacagagga gtcaaacagt   1260

gcagagatgt catgtcagat cacagcaaca agtaacgggg agggccatgg catgaaccca   1320

agtctgcagg ccatgatgct gatgggcttt ggggatatct tctcaatgaa caaagcagga   1380

gctgtgatgc attctgggat gcagataaac atgcaagcca agcagaattc ttccaaaacc   1440

acatctaaga gaagggggaa gaaagtcaac atggctctgg ggttcagtga ttttgacttg   1500

tcagaaggtg acgatgatga tgatgatgac ggtgaggagg aggataatga catggataat   1560

agtgaatgaa agcagaaagc aaagtaataa aatcacaaat gtttggaaaa cacaaaagta   1620

acttgtttat ctcagtctgt acaaaaacag taaggaggca gaaagccaag cactgcattt   1680

ttaggccaat cacatttaca tgaccgtaat ttcttatcaa ttctactttt atttttgctt   1740

acagaaaaac ggggggagaa ttaagccaaa gaagtatatt tatgaatcag caaatgtggt   1800

gcctgattat agaaatttgt gatcctatat acaatatagg acttttaaag ttgtgacatt   1860

ctggcttttt cttttaatga atacttttta gtttgtattt gactttattt cctttattca   1920

aatcattttt aaaaacttac attttgaaca aacactctta actcctaatt gttctttgac   1980

acgtagtaat tctgtgacat actttttttt tcttatagca atacactgta atatcagaaa   2040

tggttggcct gagcaaccta gtaagacctc gtctctacta ataattaaaa aactagctgg   2100

catggtagca cacacctgta gtcccagata cttgggaggc caaggcagga ggattgcttg   2160

agacctagca atcagtcagg gctgcagtga gccatgatgg caccactgca ctctagcctg   2220

ggcaagagaa caagatcctg tctcaaaaaa caaaaaaaag aaagaattga tagtacaaaa   2280

tccaacaaca atactgagat gatctaagaa ggttataaca aaatgctctt cagaaatacc   2340

taagtgctga gaatttttag tactaaagag cacagctgct caaagtaaag cctgagcagt   2400

gttctcagta atgtatttga aggaaaaata ccctgatttg aaaccaacag cagatgttgc   2460

aaactttcat accactgctg gccatggaag cctcttaaca acacactgtc atttaaggct   2520

gtgcttgtgc tttatacaaa gagaaagagg tggtcttaag gggatgcttc caggggggtg   2580

agttcatgcc tctcctgtat tttccagcaa gtggggtatg tgtggtggtt tgttttttag   2640

aggggcataa taatccagga ttctaagcat atgctcagct attttaaaga ggaaattaaa   2700

tattataaaa gaaatagtaa agataagtta tcctcactta ggcaaaagca caggtccttt   2760

ccatatcaag tttagcctac cagggttgtt ttttgtttta accctgctta ataatgttgg   2820

tgttttagaa gtagatacag gcactgctct gaaaacctgg ctagccaagg atattctcag   2880

aatgttatca cctgtttgtc aaagcttgtt taaattataa aacactttta attatatata   2940

tgaggcaaaa gaactaagac ttttttcaaa ctaaattaga aaggagtgtc attatttgac   3000

tgttaaacca aaatattttt ggtgggtctt tttatggaag tttaaagaaa ggacatcatc   3060

atagatatga tctaacagta tttctaacta tatttgatca ttaaaagcct cttggaattt   3120

gaagcgtgac gtgtttctaa tgccccttga gaggtgaaaa ataccacata atgatcagta   3180

tgctgtgcca gcttcatttg gggagaaata actagtagaa agttctgggt gtgaggtgta   3240

cagcagtcta ggtggcatag tgatgaagaa agggatcaga gtctgactgt cactcagaat   3300

cctgggctca gttgcttgac aaccttggga aaattgtttt atctttgtgc gtctgtttgc   3360

tgatcttcag cgtgggaata ataacagtac ctacttgaaa ggatcattgt gcggattaaa   3420

agaaataata tatgtaaagc actttaacac agcaccaggc ccacggaaag tggctaatgt   3480

tagctactat gaatggtgcc agtgaagaca ctgaaaaata agtgatttca gtaaccttct   3540

ggaaagctat cagtttcaaa taatattttc tctgtagtat gagatgaaat taaaagtgga   3600

tagctttcag gaaagataaa gagaacatgc ttagaatgta agctaaacag attttttctg   3660

ttgctctttg aaaactatga gccctggcca gcttaacctg gtctgaggtg agactaaaca   3720

caaaaacagt agataaatct ctccctaaaa gatggattcc cccacatacc catgctacta   3780

gtttctctgt ctattcacac atatgtacaa atacatgaac acagcctgtc tgtgctcaga   3840

catagagaag tactacctga cttgagtcaa tgcacccaag aagaaaagct tggagtagag   3900

cagaagggag ggcttgggac tcctgtcttt ccagcatgcc ctggggtgca gtggtcagcc   3960

acctgaagag agagccaata gcatggggtt tacaaggcaa agatagtcat tcattcaaca   4020

catattcata gagctccttc tctgtgccag acactgttct ggaagatagc tagatgaaaa   4080

tctttgcact cacagagctt acatgccagt gagtgaagat cgatgataaa taaagcaaat   4140

gcatcatatg ttcacatttg ataagtatat gccaaaaaat gaagccggga aggaggacaa   4200

ggcccatggg tgggtgttga ggtttttaaa gtgtggtcag gaaaggcccc actgataagg   4260

taacatttga gcaagtctga aaaaggcaag gggatctttg gggctaactt cgggatccct   4320

gcactttatg taagaatgta aacctggagt ctcatttaag aatgatcagc aatacgttta   4380

gaacatatga actgaatgaa atggacattt tttcttaatt tatgtataaa tccatatgat   4440

tatacataaa gttctgatgc attaataaaa gcagccaaat agggccaaag agaaaaataa   4500

caggactctg tactggacct aactttatca ttaattaggt aatattttcc tcatttcttt   4560

actgctgcca ttttcctcac cagtattcca gagatggtca tagctcatta ctctaccacc   4620

aagaacctaa aaggaattag aatacagcag aattggcctc agtgaagagc ttaaaattgt   4680

tctcctcgta gaactggact attgatcatt accacgtgac gttggctcta ttactttctg   4740

ttcccaatgt ccttctagtg gtttgaaaat gttaaaacat ccctaaaatc taaatcatat   4800

aatcagaatt ctatagtgtc ccactctatc tgtaaagatc atttggaaga ctttagactc   4860

tattaatttt aaaaggaata tttattagcc atatgcagaa tttctaatga tgatattgta   4920

cagcttctaa ttcacttttc agatcagtgt ttgaaatggc aattatcagt gttggattta   4980

gttccaacta cttgatttac aaaaatgtac atttagaggt taaaagaaac agtgagaaat   5040

gtaaacattc aaaatgataa ttgaatctct cagttgtggg aataattatc agagacatgc   5100

aactgaaaat gtctcacctt tcatcttttt ttcttaattc ataaagttat cttgtagaat   5160

ttgatgagac cctccctagt cattctcaac tggggcggtg ctgtcaccga atggtgtttg   5220

agagtgttgg ggctagggca catttttggt tgtcacagca actggggtgg catttgctgc   5280

ccagtgccag gaatagtaac attatgaatg ccagggacag tgtgctcagt aaagtcttcc   5340

atccaaaagg ggcagggcac ggtggctcac gcctgtaatc ccagcacttt gggaggccaa   5400

ggtgggcgga tcacctgatg tcaggggttc gagaccagcc tggccaacat ggtgaaaccc   5460

tgttgctact aaaaatacaa aaattggctg ggtgtggtgt cacatgccag taaccccagc   5520

tactagggag gctgaggcag gagaatcact tgaacccggg aggcagaggt tgcagtgagc   5580

tgagattgca ccactacact ccagcctgga tgacagagtg agacttcatc tcaaaaaaaa   5640

aaaaaaacaa aaaaaaacaa cccggtagca ttgtcccttc cccactgaca aacttatcaa   5700

atccagaagc tttagagttt cgtctctaat tatttttctc ctgaacaaaa ttacccaagt   5760

caaaacaaaa tgtattttta gaattacggc agcatacgac ctgaattttg tgagtttcgt   5820

ggctttatct taaatcacca tttccctaaa aatggtttct ttctccttag aaatgctggt   5880

ggcaacttga tgaaacagcc aaatgcacca gggcaggtca ctttcccatt acactgattc   5940

cacaattaaa aaaaaaaaag aaaaaaaact cattgagata gctacagttc tataggttaa   6000

tttaaagcct cctttttcta ctcatttttg aaagcaaaat tacattttac tattttacat   6060

aaccagtgaa aagacgttga aagcctacag ctcactgttt ttggtgctct ggaaatgttg   6120

agggtgggtt tttaaccagt gatttttaac gtgcagtgaa tttgttagac ttttaaacac   6180

cagctaaggt agtcaaactt gatccccatt aaaaatcaag gaattagggg tcgggggagg   6240

gtttaggagt gatccagaat gacctcccag aattactgtg cgtacaactt tatttttcag   6300

agttttcatt ggaatggtaa gagttttatg aaagacagtt ttaaaactta ttctgagtta   6360

aatattaata ctttaaaaaa ttattgtact agacttattg cagccttttg aaagtagcag   6420

agtttcatca taccacatat ataacagagc ataaattttc tataatcagg caccttttgc   6480

tgcttttgag taagactgtt ttcctgttta agtgttaagc atcgccagac ataaaaatct   6540

attctctcct ctcgattgta gcatagcctg acagctctag atacagcatt tctatgatga   6600

aaaatgagta tccatcagga aatctagaag actagccgtg ttttctcaga ctccaccttt   6660

gtttgcactc tgttgcctgt gaggagcttt ctggcatgtg attatttact tcaaaactag   6720

agttccaagc acctacatta attattttat attgtgtgca gaatagtata tcttttaatg   6780

tcagatatga tacactgcac atattgcttt tgcactctta aaatttttgt actaaataat   6840

agaaaatatt tatattcttt gagtgtgagc tttgaataga tggcattatc actttattgt   6900

ttttttaaca aaaacttttt ctcaattatt ctattgcaat gttattctga gcaagtccta   6960

tgccaaatat cttgtataat gtttgtatgg aagattaaat tttactcttg tgtggtaaga   7020

ctatttcagt tactgatttt atagttggaa tttgatattc cagcacaaag tccacagtgt   7080

attcagaaat ccaagttggt gtcatacatt tcattttgat gtgaactttt ctttgctttc   7140

ctttgttcta agactccatt ttgcaataaa cgttttgaca gt                      7182


<210>  8734
<211>  455
<212>  PRT
<213>  Homosapiens

<400>  8734

Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu 
        275                 280                 285             


Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys 
    290                 295                 300                 


Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln 
305                 310                 315                 320 


Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Leu Pro Leu Ala Ala 
                325                 330                 335     


Arg Met Ser Glu Glu Ser Tyr Phe Glu Ser Lys Thr Glu Glu Ser Asn 
            340                 345                 350         


Ser Ala Glu Met Ser Cys Gln Ile Thr Ala Thr Ser Asn Gly Glu Gly 
        355                 360                 365             


His Gly Met Asn Pro Ser Leu Gln Ala Met Met Leu Met Gly Phe Gly 
    370                 375                 380                 


Asp Ile Phe Ser Met Asn Lys Ala Gly Ala Val Met His Ser Gly Met 
385                 390                 395                 400 


Gln Ile Asn Met Gln Ala Lys Gln Asn Ser Ser Lys Thr Thr Ser Lys 
                405                 410                 415     


Arg Arg Gly Lys Lys Val Asn Met Ala Leu Gly Phe Ser Asp Phe Asp 
            420                 425                 430         


Leu Ser Glu Gly Asp Asp Asp Asp Asp Asp Asp Gly Glu Glu Glu Asp 
        435                 440                 445             


Asn Asp Met Asp Asn Ser Glu 
    450                 455 


<210>  8735
<211>  7197
<212>  DNA
<213>  Homosapiens

<400>  8735
gactgtcttc ctcattggcg ccgtgcagag aggcggaatg ttcaactcct aactgcagcg     60

gaaacgtggg agccgcgcgg gccgctgtcg tcccaacccc cgccgccctc gtcgcgcgcg    120

gggcctccgc gcccccggct gctgctcacg ccccgcccgg gagccagatt ttgtggaagt    180

ataatacttt gtcattatga gatgtcgtct ctcggtgcct cctttgtgca aattaaattt    240

gatgacttgc agttttttga aaactgcggt ggaggaagtt ttgggagtgt ttatcgagcc    300

aaatggatat cacaggacaa ggaggtggct gtaaagaagc tcctcaaaat agagaaagag    360

gcagaaatac tcagtgtcct cagtcacaga aacatcatcc agttttatgg agtaattctt    420

gaacctccca actatggcat tgtcacagaa tatgcttctc tgggatcact ctatgattac    480

attaacagta acagaagtga ggagatggat atggatcaca ttatgacctg ggccactgat    540

gtagccaaag gaatgcatta tttacatatg gaggctcctg tcaaggtgat tcacagagac    600

ctcaagtcaa gaaacgttgt tatagctgct gatggagtat tgaagatctg tgactttggt    660

gcctctcggt tccataacca tacaacacac atgtccttgg ttggaacttt cccatggatg    720

gctccagaag ttatccagag tctccctgtg tcagaaactt gtgacacata ttcctatggt    780

gtggttctct gggagatgct aacaagggag gtccccttta aaggtttgga aggattacaa    840

gtagcttggc ttgtagtgga aaaaaacgag agattaacca ttccaagcag ttgccccaga    900

agttttgctg aactgttaca tcagtgttgg gaagctgatg ccaagaaacg gccatcattc    960

aagcaaatca tttcaatcct ggagtccatg tcaaatgaca cgagccttcc tgacaagtgt   1020

aactcattcc tacacaacaa ggcggagtgg aggtgcgaaa ttgaggcaac tcttgagagg   1080

ctaaagaaac tagagcgtga tctcagcttt aaggagcagg agcttaaaga acgagaaaga   1140

cgtttaaaga tgtgggagca aaagctgaca gagcagtcca acaccccgct tctcttgcct   1200

cttgctgcaa gaatgtctga ggagtcttac tttgaatcta aaacagagga gtcaaacagt   1260

gcagagatgt catgtcagat cacagcaaca agtaacgggg agggccatgg catgaaccca   1320

agtctgcagg ccatgatgct gatgggcttt ggggatatct tctcaatgaa caaagcagga   1380

gctgtgatgc attctgggat gcagataaac atgcaagcca agcagaattc ttccaaaacc   1440

acatctaaga gaagggggaa gaaagtcaac atggctctgg ggttcagtga ttttgacttg   1500

tcagaaggtg acgatgatga tgatgatgac ggtgaggagg aggataatga catggataat   1560

agtgaatgaa agcagaaagc aaagtaataa aatcacaaat gtttggaaaa cacaaaagta   1620

acttgtttat ctcagtctgt acaaaaacag taaggaggca gaaagccaag cactgcattt   1680

ttaggccaat cacatttaca tgaccgtaat ttcttatcaa ttctactttt atttttgctt   1740

acagaaaaac ggggggagaa ttaagccaaa gaagtatatt tatgaatcag caaatgtggt   1800

gcctgattat agaaatttgt gatcctatat acaatatagg acttttaaag ttgtgacatt   1860

ctggcttttt cttttaatga atacttttta gtttgtattt gactttattt cctttattca   1920

aatcattttt aaaaacttac attttgaaca aacactctta actcctaatt gttctttgac   1980

acgtagtaat tctgtgacat actttttttt tcttatagca atacactgta atatcagaaa   2040

tggttggcct gagcaaccta gtaagacctc gtctctacta ataattaaaa aactagctgg   2100

catggtagca cacacctgta gtcccagata cttgggaggc caaggcagga ggattgcttg   2160

agacctagca atcagtcagg gctgcagtga gccatgatgg caccactgca ctctagcctg   2220

ggcaagagaa caagatcctg tctcaaaaaa caaaaaaaag aaagaattga tagtacaaaa   2280

tccaacaaca atactgagat gatctaagaa ggttataaca aaatgctctt cagaaatacc   2340

taagtgctga gaatttttag tactaaagag cacagctgct caaagtaaag cctgagcagt   2400

gttctcagta atgtatttga aggaaaaata ccctgatttg aaaccaacag cagatgttgc   2460

aaactttcat accactgctg gccatggaag cctcttaaca acacactgtc atttaaggct   2520

gtgcttgtgc tttatacaaa gagaaagagg tggtcttaag gggatgcttc caggggggtg   2580

agttcatgcc tctcctgtat tttccagcaa gtggggtatg tgtggtggtt tgttttttag   2640

aggggcataa taatccagga ttctaagcat atgctcagct attttaaaga ggaaattaaa   2700

tattataaaa gaaatagtaa agataagtta tcctcactta ggcaaaagca caggtccttt   2760

ccatatcaag tttagcctac cagggttgtt ttttgtttta accctgctta ataatgttgg   2820

tgttttagaa gtagatacag gcactgctct gaaaacctgg ctagccaagg atattctcag   2880

aatgttatca cctgtttgtc aaagcttgtt taaattataa aacactttta attatatata   2940

tgaggcaaaa gaactaagac ttttttcaaa ctaaattaga aaggagtgtc attatttgac   3000

tgttaaacca aaatattttt ggtgggtctt tttatggaag tttaaagaaa ggacatcatc   3060

atagatatga tctaacagta tttctaacta tatttgatca ttaaaagcct cttggaattt   3120

gaagcgtgac gtgtttctaa tgccccttga gaggtgaaaa ataccacata atgatcagta   3180

tgctgtgcca gcttcatttg gggagaaata actagtagaa agttctgggt gtgaggtgta   3240

cagcagtcta ggtggcatag tgatgaagaa agggatcaga gtctgactgt cactcagaat   3300

cctgggctca gttgcttgac aaccttggga aaattgtttt atctttgtgc gtctgtttgc   3360

tgatcttcag cgtgggaata ataacagtac ctacttgaaa ggatcattgt gcggattaaa   3420

agaaataata tatgtaaagc actttaacac agcaccaggc ccacggaaag tggctaatgt   3480

tagctactat gaatggtgcc agtgaagaca ctgaaaaata agtgatttca gtaaccttct   3540

ggaaagctat cagtttcaaa taatattttc tctgtagtat gagatgaaat taaaagtgga   3600

tagctttcag gaaagataaa gagaacatgc ttagaatgta agctaaacag attttttctg   3660

ttgctctttg aaaactatga gccctggcca gcttaacctg gtctgaggtg agactaaaca   3720

caaaaacagt agataaatct ctccctaaaa gatggattcc cccacatacc catgctacta   3780

gtttctctgt ctattcacac atatgtacaa atacatgaac acagcctgtc tgtgctcaga   3840

catagagaag tactacctga cttgagtcaa tgcacccaag aagaaaagct tggagtagag   3900

cagaagggag ggcttgggac tcctgtcttt ccagcatgcc ctggggtgca gtggtcagcc   3960

acctgaagag agagccaata gcatggggtt tacaaggcaa agatagtcat tcattcaaca   4020

catattcata gagctccttc tctgtgccag acactgttct ggaagatagc tagatgaaaa   4080

tctttgcact cacagagctt acatgccagt gagtgaagat cgatgataaa taaagcaaat   4140

gcatcatatg ttcacatttg ataagtatat gccaaaaaat gaagccggga aggaggacaa   4200

ggcccatggg tgggtgttga ggtttttaaa gtgtggtcag gaaaggcccc actgataagg   4260

taacatttga gcaagtctga aaaaggcaag gggatctttg gggctaactt cgggatccct   4320

gcactttatg taagaatgta aacctggagt ctcatttaag aatgatcagc aatacgttta   4380

gaacatatga actgaatgaa atggacattt tttcttaatt tatgtataaa tccatatgat   4440

tatacataaa gttctgatgc attaataaaa gcagccaaat agggccaaag agaaaaataa   4500

caggactctg tactggacct aactttatca ttaattaggt aatattttcc tcatttcttt   4560

actgctgcca ttttcctcac cagtattcca gagatggtca tagctcatta ctctaccacc   4620

aagaacctaa aaggaattag aatacagcag aattggcctc agtgaagagc ttaaaattgt   4680

tctcctcgta gaactggact attgatcatt accacgtgac gttggctcta ttactttctg   4740

ttcccaatgt ccttctagtg gtttgaaaat gttaaaacat ccctaaaatc taaatcatat   4800

aatcagaatt ctatagtgtc ccactctatc tgtaaagatc atttggaaga ctttagactc   4860

tattaatttt aaaaggaata tttattagcc atatgcagaa tttctaatga tgatattgta   4920

cagcttctaa ttcacttttc agatcagtgt ttgaaatggc aattatcagt gttggattta   4980

gttccaacta cttgatttac aaaaatgtac atttagaggt taaaagaaac agtgagaaat   5040

gtaaacattc aaaatgataa ttgaatctct cagttgtggg aataattatc agagacatgc   5100

aactgaaaat gtctcacctt tcatcttttt ttcttaattc ataaagttat cttgtagaat   5160

ttgatgagac cctccctagt cattctcaac tggggcggtg ctgtcaccga atggtgtttg   5220

agagtgttgg ggctagggca catttttggt tgtcacagca actggggtgg catttgctgc   5280

ccagtgccag gaatagtaac attatgaatg ccagggacag tgtgctcagt aaagtcttcc   5340

atccaaaagg ggcagggcac ggtggctcac gcctgtaatc ccagcacttt gggaggccaa   5400

ggtgggcgga tcacctgatg tcaggggttc gagaccagcc tggccaacat ggtgaaaccc   5460

tgttgctact aaaaatacaa aaattggctg ggtgtggtgt cacatgccag taaccccagc   5520

tactagggag gctgaggcag gagaatcact tgaacccggg aggcagaggt tgcagtgagc   5580

tgagattgca ccactacact ccagcctgga tgacagagtg agacttcatc tcaaaaaaaa   5640

aaaaaaacaa aaaaaaacaa cccggtagca ttgtcccttc cccactgaca aacttatcaa   5700

atccagaagc tttagagttt cgtctctaat tatttttctc ctgaacaaaa ttacccaagt   5760

caaaacaaaa tgtattttta gaattacggc agcatacgac ctgaattttg tgagtttcgt   5820

ggctttatct taaatcacca tttccctaaa aatggtttct ttctccttag aaatgctggt   5880

ggcaacttga tgaaacagcc aaatgcacca gggcaggtca ctttcccatt acactgattc   5940

cacaattaaa aaaaaaaaag aaaaaaaact cattgagata gctacagttc tataggttaa   6000

tttaaagcct cctttttcta ctcatttttg aaagcaaaat tacattttac tattttacat   6060

aaccagtgaa aagacgttga aagcctacag ctcactgttt ttggtgctct ggaaatgttg   6120

agggtgggtt tttaaccagt gatttttaac gtgcagtgaa tttgttagac ttttaaacac   6180

cagctaaggt agtcaaactt gatccccatt aaaaatcaag gaattagggg tcgggggagg   6240

gtttaggagt gatccagaat gacctcccag aattactgtg cgtacaactt tatttttcag   6300

agttttcatt ggaatggtaa gagttttatg aaagacagtt ttaaaactta ttctgagtta   6360

aatattaata ctttaaaaaa ttattgtact agacttattg cagccttttg aaagtagcag   6420

agtttcatca taccacatat ataacagagc ataaattttc tataatcagg caccttttgc   6480

tgcttttgag taagactgtt ttcctgttta agtgttaagc atcgccagac ataaaaatct   6540

attctctcct ctcgattgta gcatagcctg acagctctag atacagcatt tctatgatga   6600

aaaatgagta tccatcagga aatctagaag actagccgtg ttttctcaga ctccaccttt   6660

gtttgcactc tgttgcctgt gaggagcttt ctggcatgtg attatttact tcaaaactag   6720

agttccaagc acctacatta attattttat attgtgtgca gaatagtata tcttttaatg   6780

tcagatatga tacactgcac atattgcttt tgcactctta aaatttttgt actaaataat   6840

agaaaatatt tatattcttt gagtgtgagc tttgaataga tggcattatc actttattgt   6900

ttttttaaca aaaacttttt ctcaattatt ctattgcaat gttattctga gcaagtccta   6960

tgccaaatat cttgtataat gtttgtatgg aagattaaat tttactcttg tgtggtaaga   7020

ctatttcagt tactgatttt atagttggaa tttgatattc cagcacaaag tccacagtgt   7080

attcagaaat ccaagttggt gtcatacatt tcattttgat gtgaactttt ctttgctttc   7140

ctttgttcta agactccatt ttgcaataaa cgttttgaca gtaaatccct ttgttac      7197


<210>  8736
<211>  455
<212>  PRT
<213>  Homosapiens

<400>  8736

Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu 
        275                 280                 285             


Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys 
    290                 295                 300                 


Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln 
305                 310                 315                 320 


Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Leu Pro Leu Ala Ala 
                325                 330                 335     


Arg Met Ser Glu Glu Ser Tyr Phe Glu Ser Lys Thr Glu Glu Ser Asn 
            340                 345                 350         


Ser Ala Glu Met Ser Cys Gln Ile Thr Ala Thr Ser Asn Gly Glu Gly 
        355                 360                 365             


His Gly Met Asn Pro Ser Leu Gln Ala Met Met Leu Met Gly Phe Gly 
    370                 375                 380                 


Asp Ile Phe Ser Met Asn Lys Ala Gly Ala Val Met His Ser Gly Met 
385                 390                 395                 400 


Gln Ile Asn Met Gln Ala Lys Gln Asn Ser Ser Lys Thr Thr Ser Lys 
                405                 410                 415     


Arg Arg Gly Lys Lys Val Asn Met Ala Leu Gly Phe Ser Asp Phe Asp 
            420                 425                 430         


Leu Ser Glu Gly Asp Asp Asp Asp Asp Asp Asp Gly Glu Glu Glu Asp 
        435                 440                 445             


Asn Asp Met Asp Asn Ser Glu 
    450                 455 


<210>  8737
<211>  4009
<212>  DNA
<213>  Homosapiens

<400>  8737
tcttcctcat tggcgccgtg cagagaggcg gaatgttcaa ctcctaactg cagcggaaac     60

gtgggagccg cgcgggccgc tgtcgtccca acccccgccg ccctcgtcgc gcgcggggcc    120

tccgcgcccc cggctgctgc tcacgccccg cccgggagcc agattttgtg gaagtataat    180

actttgtcat tatgagatgt cgtctctcgg tgcctccttt gtgcaaatta aatttgatga    240

cttgcagttt tttgaaaact gcggtggagg aagttttggg agtgtttatc gagccaaatg    300

gatatcacag gacaaggagg tggctgtaaa gaagctcctc aaaatagaga aagaggcaga    360

aatactcagt gtcctcagtc acagaaacat catccagttt tatggagtaa ttcttgaacc    420

tcccaactat ggcattgtca cagaatatgc ttctctggga tcactctatg attacattaa    480

cagtaacaga agtgaggaga tggatatgga tcacattatg acctgggcca ctgatgtagc    540

caaaggaatg cattatttac atatggaggc tcctgtcaag gtgattcaca gagacctcaa    600

gtcaagaaac gttgttatag ctgctgatgg agtattgaag atctgtgact ttggtgcctc    660

tcggttccat aaccatacaa cacacatgtc cttggttgga actttcccat ggatggctcc    720

agaagttatc cagagtctcc ctgtgtcaga aacttgtgac acatattcct atggtgtggt    780

tctctgggag atgctaacaa gggaggtccc ctttaaaggt ttggaaggat tacaagtagc    840

ttggcttgta gtggaaaaaa acgagagatt aaccattcca agcagttgcc ccagaagttt    900

tgctgaactg ttacatcagt gttgggaagc tgatgccaag aaacggccat cattcaagca    960

aatcatttca atcctggagt ccatgtcaaa tgacacgagc cttcctgaca agtgtaactc   1020

attcctacac aacaaggcgg agtggaggtg ggtagccccg acagcaggcc acagcgtctg   1080

gctttcaaag accatcactc gtctcaatga agaagtgaac cagagatctg aatgacagtc   1140

ctgatttctg accatagctt agggaaaaag aaaaggtttt ttttatgatt ttggaactct   1200

tataagtcct gcatttcata agcaagaaat agtgtttctc caagcttgtt gccttgtgta   1260

agtatttgaa aagaatattg aggccggtcg cggtggctca cgcctgtaat cccagctctt   1320

tgggaggcca aggcaggcag atcacctgag gtcaggagtt tgagaccacc ttgaccaaca   1380

tggagaaacc ctgtctctac taaaaataca aaaaattagc caggtgtggt ggcacatgcc   1440

tgtaatccca gctactcagg aggctgaggc aggagaatca cttgaacctg gaggcagagg   1500

ttgcagtgag ccgagatcat gccattgcac tccagcctga gcaacaagag tgaaaaactc   1560

catctcaaaa aaaaaaaaat tgaaatcctg tcttctgaga caaaagatgg ttaccagaca   1620

tttctctgtg tttactttgt taggaagctt tgtcctctgt tgtgtaagaa acaagaatac   1680

tgtttacctt gaaattcgct gagcactgtg tctgctagtg aagggggata gggagacatc   1740

aaaaatactc ttaaaagaaa acttgatatc ataaatccta ttaaagcttg ttaaataaat   1800

ttagtaatga gaaaattgta ttgcatgagt ggaagagtaa acccaggatg aaacatttga   1860

gccaggtcac atgatgcatg actataaata gcatgtttgg aagctgacat tattcccccc   1920

ctgactcagc ggagatttag gtaacttcat ctctgctccc gatagccgtg ggcagtaaca   1980

tgacgcctta cgccatctgc tgatgccaaa tgaatactgc atgcactttg aaaattactg   2040

cgttgtttac tcctgttact agatacttct ttgggctttc tgtttgttgt tttacaataa   2100

ccttatttat ttttattcct ttgaaatatc ttatctaggg ctagtgaggt aaatgaattt   2160

ttatttaggg atacaaaaat tatacagtga gctcaagtct aggtataagg gacttttttc   2220

tgggctgaga taattaacaa aacagaacat ttaagtaata tttgtttttt gcagtaagag   2280

atcagtatac atgtcatcag atcattctcc tttaaaatcc atatatgagt tcccattact   2340

cttaagacaa agaccagaat acttggcaca gtggctcatg cctgtaatcc cagcacttca   2400

ggaggccaag gctggtggat tacttgagcc caggagttca agcccagcct ggtgacagag   2460

caagaatcat tctcaagaaa tgaaaaggac cagaatactt aagaagactc accagaccct   2520

cattactgtg gcctcaccag tgtcagctta agaagatcat tctcccctta atttctggct   2580

ttcagtccct caacagatgc gtatttctcc ccttttcagg atctttacaa gcagtttcct   2640

ctctttgaag cttatcccat ttcagctgtg taccacgcct gccgtcacac cccaccttaa   2700

ctcctgttca tcattcacat ggcagttgaa taacacgtct gcagggaaac acttcctgac   2760

cccaggccag atcaggttcc actttatgtg ctctgagagc atctccttca taggctttgc   2820

tgctattgga attaagaagt aattcgggcc aggcacagtg gctcacgcct gtaatcccag   2880

cactttggga ggccaagtca ggtggatcaa cgtcaggaga tcgagaccat actggctaac   2940

acggtgaaac cccatctcta ctaaaaatac aaaaaattag ccaggcatgg tggcgggtgc   3000

ctgtagtccc agctacttgg gaggctgagg caggagaatg gcgtgaaccc gggaggcaga   3060

ggttgcagtg agctgagatc gcgccactgc actccagcct gggcgacaca gcaagactcc   3120

gtctcaaaaa aaaagaagta attcggcagt tagttgttta atgtgtgtct cacgggctga   3180

aatataagag aggcagacaa tcacgtttgt tcatcactca cagcatcaaa atgtgccttg   3240

aacacagcat ttgctccgta aatatttggg gaagcaagag agaaaattac catggtggta   3300

ataatataaa aagagattgt gatattatac aagagaatat aaatatgtat gtttgccatg   3360

acaaaagtac ttcttatgtt cattcattca ttatccattc attgaacttc tgctggtgtg   3420

agaacgactg ttgccattcg ggtactgggc tgtagcgatg agcacaagag tcccagggca   3480

tgtggagctc tccagcccga gtgtccaatg ttaaactatt aaatatattc aaaactatcg   3540

catttctatt ttgacaagta ttatgacaga gaaatatact agatgtctga gagcatatgg   3600

ccatgaaatc tgatctagtc caaggacata gtaaaaggat tttggagaaa atgctatttg   3660

atctattacc gaagggatta gtaagatttt aataccaaga tagggagtct tttaaagtat   3720

gtcaacaagg ccaggcgtgg tagctcacac ctgtaatccc aacactttgg gaggccgaag   3780

tgaaagactg cttgagccca gaagttcaag actagcctga gcaacgtaga cctcatctct   3840

actcacaatt taaaaattag ctgggcattg tgactctaac ctgtggtccc agttactcaa   3900

ctcgggaggc tgaggtggga ggatcacttg agctggggag gtcaaagctg cattgagccg   3960

agatctggcc acgacactcc agcctgggct acagagtgag atcctattc               4009


<210>  8738
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  8738

Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Trp Val Ala Pro 
        275                 280                 285             


Thr Ala Gly His Ser Val Trp Leu Ser Lys Thr Ile Thr Arg Leu Asn 
    290                 295                 300                 


Glu Glu Val Asn Gln Arg Ser Glu 
305                 310         


<210>  8739
<211>  1601
<212>  DNA
<213>  Homosapiens

<400>  8739
tcttcctcat tggcgccgtg cagagaggcg gaatgttcaa ctcctaactg cagcggaaac     60

gtgggagccg cgcgggccgc tgtcgtccca acccccgccg ccctcgtcgc gcgcggggcc    120

tccgcgcccc cggctgctgc tcacgccccg cccgggagcc agattttgtg gaagtataat    180

actttgtcat tatgagatgt cgtctctcgg tgcctccttt gtgcaaatta aatttgatga    240

cttgcagttt tttgaaaact gcggtggagg aagttttggg agtgtttatc gagccaaatg    300

gatatcacag gacaaggagg tggctgtaaa gaagctcctc aaaatagaga aagaggcaga    360

aatactcagt gtcctcagtc acagaaacat catccagttt tatggagtaa ttcttgaacc    420

tcccaactat ggcattgtca cagaatatgc ttctctggga tcactctatg attacattaa    480

cagtaacaga agtgaggaga tggatatgga tcacattatg acctgggcca ctgatgtagc    540

caaaggaatg cattatttac atatggaggc tcctgtcaag gtgattcaca gagacctcaa    600

gtcaagaaac gttgttatag ctgctgatgg agtattgaag atctgtgact ttggtgcctc    660

tcggttccat aaccatacaa cacacatgtc cttggttgga actttcccat ggatggctcc    720

agaagttatc cagagtctcc ctgtgtcaga aacttgtgac acatattcct atggtgtggt    780

tctctgggag atgctaacaa gggaggtccc ctttaaaggt ttggaaggat tacaagtagc    840

ttggcttgta gtggaaaaaa acgagagatt aaccattcca agcagttgcc ccagaagttt    900

tgctgaactg ttacatcagt gttgggaagc tgatgccaag aaacggccat cattcaagca    960

aatcatttca atcctggagt ccatgtcaaa tgacacgagc cttcctgaca agtgtaactc   1020

attcctacac aacaaggcgg agtggaggtg cgaaattgag gcaactcttg agaggctaaa   1080

gaaactagag cgtgatctca gctttaagga gcaggagctt aaagaacgag aaagacgttt   1140

aaagatgtgg gagcaaaagc tgacagagca gtccaacacc ccgcttctct tgcctcttgc   1200

tgcaagaatg tctgaggagt cttactttga atctaaaaca gaggagtcaa acagtgcaga   1260

gatgtcatgt cagatcacag caacaagtaa cggggagggc catggcatga acccaagtct   1320

gcaggccatg atgctgatgg gctttgggga tatcttctca atgaacaaag caggagctgt   1380

gatgcattct gggatgcaga taaacatgca agccaagcag aattcttcca aaaccacatc   1440

taagagaagg gggaagaaag tcaacatggc tctggggttc agtgattttg acttgtcaga   1500

aggtgacgat gatgatgatg atgacggtga ggaggaggat aatgacatgg ataatagtga   1560

atgaaagcag aaagcaaagt aataaaatca caaatgtttg g                       1601


<210>  8740
<211>  455
<212>  PRT
<213>  Homosapiens

<400>  8740

Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu 
        275                 280                 285             


Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys 
    290                 295                 300                 


Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln 
305                 310                 315                 320 


Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Leu Pro Leu Ala Ala 
                325                 330                 335     


Arg Met Ser Glu Glu Ser Tyr Phe Glu Ser Lys Thr Glu Glu Ser Asn 
            340                 345                 350         


Ser Ala Glu Met Ser Cys Gln Ile Thr Ala Thr Ser Asn Gly Glu Gly 
        355                 360                 365             


His Gly Met Asn Pro Ser Leu Gln Ala Met Met Leu Met Gly Phe Gly 
    370                 375                 380                 


Asp Ile Phe Ser Met Asn Lys Ala Gly Ala Val Met His Ser Gly Met 
385                 390                 395                 400 


Gln Ile Asn Met Gln Ala Lys Gln Asn Ser Ser Lys Thr Thr Ser Lys 
                405                 410                 415     


Arg Arg Gly Lys Lys Val Asn Met Ala Leu Gly Phe Ser Asp Phe Asp 
            420                 425                 430         


Leu Ser Glu Gly Asp Asp Asp Asp Asp Asp Asp Gly Glu Glu Glu Asp 
        435                 440                 445             


Asn Asp Met Asp Asn Ser Glu 
    450                 455 


<210>  8741
<211>  3374
<212>  DNA
<213>  Homosapiens

<400>  8741
tcttcctcat tggcgccgtg cagagaggcg gaatgttcaa ctcctaactg cagcggaaac     60

gtgggagccg cgcgggccgc tgtcgtccca acccccgccg ccctcgtcgc gcgcggggcc    120

tccgcgcccc cggctgctgc tcacgccccg cccgggagcc agattttgtg gaagtataat    180

actttgtcat tatgagatgt cgtctctcgg tgcctccttt gtgcaaatta aatttgatga    240

cttgcagttt tttgaaaact gcggtggagg aagttttggg agtgtttatc gagccaaatg    300

gatatcacag gacaaggagg tggctgtaaa gaagctcctc aaaatagaga aagaggcaga    360

aatactcagt gtcctcagtc acagaaacat catccagttt tatggagtaa ttcttgaacc    420

tcccaactat ggcattgtca cagaatatgc ttctctggga tcactctatg attacattaa    480

cagtaacaga agtgaggaga tggatatgga tcacattatg acctgggcca ctgatgtagc    540

caaaggaatg cattatttac atatggaggc tcctgtcaag gtgattcaca gagacctcaa    600

gtcaagaaac gttgttatag ctgctgatgg agtattgaag atctgtgact ttggtgcctc    660

tcggttccat aaccatacaa cacacatgtc cttggttgga actttcccat ggatggctcc    720

agaagttatc cagagtctcc ctgtgtcaga aacttgtgac acatattcct atggtgtggt    780

tctctgggag atgctaacaa gggaggtccc ctttaaaggt ttggaaggat tacaagtagc    840

ttggcttgta gtggaaaaaa acgagagatt aaccattcca agcagttgcc ccagaagttt    900

tgctgaactg ttacatcagt gttgggaagc tgatgccaag aaacggccat cattcaagca    960

aatcatttca atcctggagt ccatgtcaaa tgacacgagc cttcctgaca agtgtaactc   1020

attcctacac aacaaggcgg agtggaggtg cgaaattgag gcaactcttg agaggctaaa   1080

gaaactagag cgtgatctca gctttaagga gcaggagctt aaagaacgag aaagacgttt   1140

aaagatgtgg gagcaaaagc tgacagagca gtccaacacc ccgctgctgc cttcctttga   1200

gattggtgca tggacggaag acgatgtgta ttgttgggtt cagcagctcg tcagaaaagg   1260

tgactcttca gcagagatga gtgtatatgc aagcttgttt aaagaaaaca acattacagg   1320

gaagcggctg ctgctgctgg aggaagaaga cctgaaagac atgggcattg tctccaaggg   1380

gcatatcatt cacttcaagt cagccattga gaaattaacc catgattaca taaatttgtt   1440

tcacttccca ccactaatta aggactcagg aggtgaacct gaagaaaatg aggaaaaaat   1500

agtgaacctg gaactggttt ttggttttca cttgaaacca ggaactggcc cacaggattg   1560

taagtggaaa atgtatatgg agatggatgg ggatgaaatt gcaataacct acataaaaga   1620

tgtgacattc aacactaacc tacctgatgc ggagatttta aagatgacaa agccaccatt   1680

tgtaatggag aagtggattg taggaatagc aaaaagtcag actgtggagt gcactgtcac   1740

atatgagagt gatgttagaa ctccaaaaag cactaaacat gtccattcga ttcagtggag   1800

tagaacaaaa cctcaggatg aagtgaaagc agtccaactt gccattcaga cattattcac   1860

caattcagat ggcaaccctg gaagcaggtc cgactcaagt gctgattgcc agtggttaga   1920

tactctgagg atgcggcaga ttgcatccaa cacttcttta cagcgttccc agagcaatcc   1980

tattctgggg tcaccgttct tctcacactt tgatggccag gattcctacg ctgctgctgt   2040

gagacggccc caggtgccca ttaagtatca acagattaca cctgtgaacc agtccagaag   2100

ctcgtctcct actcagtatg gactgaccaa aaacttctct tccctacatc tcaactctag   2160

ggacagtggc ttttccagtg gcaatactga cacctcttca gagaggggtc gatactcaga   2220

cagaagcagg aacaaatatg gacgtggtag tatatcactc aattcttctc ctagaggaag   2280

atacagtgga aagagtcagc attccactcc ttcaagagga agataccctg gaaagttcta   2340

cagggtttct cagtcagcac tcaatcctca ccagtcgcct gacttcaaga gaagccccag   2400

ggacctccac caacccaaca ccataccagg gatgcctttg caccctgaga ctgactcaag   2460

agccagtgaa gaggacagca aagtcagcga agggggctgg acaaaagtgg aataccggaa   2520

aaagccccac aggccatctc ccgccaaaac caataaagag agagccagag gggaccaccg   2580

tggatggaga aacttttgat gaattgaact acatagcttt tctaagcagg ttaaaaaaaa   2640

aaaaaaaaag aaatgtaatg gtttttgata atatgatccc ttcagattga attaacgaaa   2700

agacaacact tccagttttt ggattgggaa ataccttcta attgagacta tagccaaacc   2760

agggccaaaa ttatggatat tggtcaccca gtgatcataa ctaggcttga aaatcactac   2820

acatattttc tgccttgagt gaacattttt agaggaaagg ttatgccatc tttttaccct   2880

aaccactgat attctggtta gcagggccag gacaagggga aggaaaatga ggtcaacaaa   2940

aaaatcaaat ttttaggaaa agataagatg aatgttactg atttttcctt ttggctgagg   3000

ctgcaatatg gcctggcaag gcactgttac tgatcttgtc tttaacattt tgatattttg   3060

ttcatcataa tttttgcatt tattttttta aatattgcat taaaatatca tttagcttga   3120

ttatcgagtt ttttggtttg aggttttttg ttgcttcttt tttcttttct ttctttcccc   3180

ctcttttttt tggatgtccc cttaaatttt gtgcccaagg caggtacctc actcatctca   3240

tccttggctc agccctgctg gttagtattt agtatttatt ttagtaagat atttgtgtct   3300

gtatgatggt cagagttgaa ctgatctggc ttgtcatttt tcagtaataa aaaaagttac   3360

tgaatttaat gttg                                                     3374


<210>  8742
<211>  800
<212>  PRT
<213>  Homosapiens

<400>  8742

Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu 
        275                 280                 285             


Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys 
    290                 295                 300                 


Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln 
305                 310                 315                 320 


Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Pro Ser Phe Glu Ile 
                325                 330                 335     


Gly Ala Trp Thr Glu Asp Asp Val Tyr Cys Trp Val Gln Gln Leu Val 
            340                 345                 350         


Arg Lys Gly Asp Ser Ser Ala Glu Met Ser Val Tyr Ala Ser Leu Phe 
        355                 360                 365             


Lys Glu Asn Asn Ile Thr Gly Lys Arg Leu Leu Leu Leu Glu Glu Glu 
    370                 375                 380                 


Asp Leu Lys Asp Met Gly Ile Val Ser Lys Gly His Ile Ile His Phe 
385                 390                 395                 400 


Lys Ser Ala Ile Glu Lys Leu Thr His Asp Tyr Ile Asn Leu Phe His 
                405                 410                 415     


Phe Pro Pro Leu Ile Lys Asp Ser Gly Gly Glu Pro Glu Glu Asn Glu 
            420                 425                 430         


Glu Lys Ile Val Asn Leu Glu Leu Val Phe Gly Phe His Leu Lys Pro 
        435                 440                 445             


Gly Thr Gly Pro Gln Asp Cys Lys Trp Lys Met Tyr Met Glu Met Asp 
    450                 455                 460                 


Gly Asp Glu Ile Ala Ile Thr Tyr Ile Lys Asp Val Thr Phe Asn Thr 
465                 470                 475                 480 


Asn Leu Pro Asp Ala Glu Ile Leu Lys Met Thr Lys Pro Pro Phe Val 
                485                 490                 495     


Met Glu Lys Trp Ile Val Gly Ile Ala Lys Ser Gln Thr Val Glu Cys 
            500                 505                 510         


Thr Val Thr Tyr Glu Ser Asp Val Arg Thr Pro Lys Ser Thr Lys His 
        515                 520                 525             


Val His Ser Ile Gln Trp Ser Arg Thr Lys Pro Gln Asp Glu Val Lys 
    530                 535                 540                 


Ala Val Gln Leu Ala Ile Gln Thr Leu Phe Thr Asn Ser Asp Gly Asn 
545                 550                 555                 560 


Pro Gly Ser Arg Ser Asp Ser Ser Ala Asp Cys Gln Trp Leu Asp Thr 
                565                 570                 575     


Leu Arg Met Arg Gln Ile Ala Ser Asn Thr Ser Leu Gln Arg Ser Gln 
            580                 585                 590         


Ser Asn Pro Ile Leu Gly Ser Pro Phe Phe Ser His Phe Asp Gly Gln 
        595                 600                 605             


Asp Ser Tyr Ala Ala Ala Val Arg Arg Pro Gln Val Pro Ile Lys Tyr 
    610                 615                 620                 


Gln Gln Ile Thr Pro Val Asn Gln Ser Arg Ser Ser Ser Pro Thr Gln 
625                 630                 635                 640 


Tyr Gly Leu Thr Lys Asn Phe Ser Ser Leu His Leu Asn Ser Arg Asp 
                645                 650                 655     


Ser Gly Phe Ser Ser Gly Asn Thr Asp Thr Ser Ser Glu Arg Gly Arg 
            660                 665                 670         


Tyr Ser Asp Arg Ser Arg Asn Lys Tyr Gly Arg Gly Ser Ile Ser Leu 
        675                 680                 685             


Asn Ser Ser Pro Arg Gly Arg Tyr Ser Gly Lys Ser Gln His Ser Thr 
    690                 695                 700                 


Pro Ser Arg Gly Arg Tyr Pro Gly Lys Phe Tyr Arg Val Ser Gln Ser 
705                 710                 715                 720 


Ala Leu Asn Pro His Gln Ser Pro Asp Phe Lys Arg Ser Pro Arg Asp 
                725                 730                 735     


Leu His Gln Pro Asn Thr Ile Pro Gly Met Pro Leu His Pro Glu Thr 
            740                 745                 750         


Asp Ser Arg Ala Ser Glu Glu Asp Ser Lys Val Ser Glu Gly Gly Trp 
        755                 760                 765             


Thr Lys Val Glu Tyr Arg Lys Lys Pro His Arg Pro Ser Pro Ala Lys 
    770                 775                 780                 


Thr Asn Lys Glu Arg Ala Arg Gly Asp His Arg Gly Trp Arg Asn Phe 
785                 790                 795                 800 


<210>  8743
<211>  3861
<212>  DNA
<213>  Homosapiens

<400>  8743
tcttcctcat tggcgccgtg cagagaggcg gaatgttcaa ctcctaactg cagcggaaac     60

gtgggagccg cgcgggccgc tgtcgtccca acccccgccg ccctcgtcgc gcgcggggcc    120

tccgcgcccc cggctgctgc tcacgccccg cccgggagcc agattttgtg gaagtataat    180

actttgtcat tatgagatgt cgtctctcgg tgcctccttt gtgcaaatta aatttgatga    240

cttgcagttt tttgaaaact gcggtggagg aagttttggg agtgtttatc gagccaaatg    300

gatatcacag gacaaggagg tggctgtaaa gaagctcctc aaaatagaga aagaggcaga    360

aatactcagt gtcctcagtc acagaaacat catccagttt tatggagtaa ttcttgaacc    420

tcccaactat ggcattgtca cagaatatgc ttctctggga tcactctatg attacattaa    480

cagtaacaga agtgaggaga tggatatgga tcacattatg acctgggcca ctgatgtagc    540

caaaggaatg cattatttac atatggaggc tcctgtcaag gtgattcaca gagacctcaa    600

gtcaagaaac gttgttatag ctgctgatgg agtattgaag atctgtgact ttggtgcctc    660

tcggttccat aaccatacaa cacacatgtc cttggttgga actttcccat ggatggctcc    720

agaagttatc cagagtctcc ctgtgtcaga aacttgtgac acatattcct atggtgtggt    780

tctctgggag atgctaacaa gggaggtccc ctttaaaggt ttggaaggat tacaagtagc    840

ttggcttgta gtggaaaaaa acgagagatt aaccattcca agcagttgcc ccagaagttt    900

tgctgaactg ttacatcagt gttgggaagc tgatgccaag aaacggccat cattcaagca    960

aatcatttca atcctggagt ccatgtcaaa tgacacgagc cttcctgaca agtgtaactc   1020

attcctacac aacaaggcgg agtggaggtg cgaaattgag gcaactcttg agaggctaaa   1080

gaaactagag cgtgatctca gctttaagga gcaggagctt aaagaacgag aaagacgttt   1140

aaagatgtgg gagcaaaagc tgacagagca gtccaacacc ccgctgctgc cttcctttga   1200

gattggtgca tggacggaag acgatgtgta ttgttgggtt cagcagctcg tcagaaaagg   1260

tgactcttca gcagagatga gtgtatatgc aagcttgttt aaagaaaaca acattacagg   1320

gaagcggctg ctgctgctgg aggaagaaga cctgaaagac atgggcattg tctccaaggg   1380

gcatatcatt cacttcaagt cagccattga gaaattaacc catgattaca taaatttgtt   1440

tcacttccca ccactaatta aggactcagg aggtgaacct gaagaaaatg aggaaaaaat   1500

agtgaacctg gaactggttt ttggttttca cttgaaacca ggaactggcc cacaggattg   1560

taagtggaaa atgtatatgg agatggatgg ggatgaaatt gcaataacct acataaaaga   1620

tgtgacattc aacactaacc tacctgatgc ggagatttta aagatgacaa agccaccatt   1680

tgtaatggag aagtggattg taggaatagc aaaaagtcag actgtggagt gcactgtcac   1740

atatgagagt gatgttagaa ctccaaaaag cactaaacat gtccattcga ttcagtggag   1800

tagaacaaaa cctcaggatg aagtgaaagc agtccaactt gccattcaga cattattcac   1860

caattcagat ggcaaccctg gaagcaggtc cgactcaagt gctgattgcc agtggttaga   1920

tactctgagg atgcggcaga ttgcatccaa cacttcttta cagcgttccc agagcaatcc   1980

tattctgggg tcaccgttct tctcacactt tgatggccag gattcctacg ctgctgctgt   2040

gagacggccc caggtgccca ttaagtatca acagattaca cctgtgaacc agtccagaag   2100

ctcgtctcct actcagtatg gactgaccaa aaacttctct tccctacatc tcaactctag   2160

ggacagtggc ttttccagtg gcaatactga cacctcttca gagaggggtc gatactcaga   2220

cagaagcagg aacaaatatg gacgtggtag tatatcactc aattcttctc ctagaggaag   2280

atacagtgga aagagtcagc attccactcc ttcaagagga agataccctg gaaagttcta   2340

cagggtttct cagtcagcac tcaatcctca ccagtcgcct gacttcaaga gaagccccag   2400

ggacctccac caacccaaca ccataccagg gatgcctttg caccctgaga ctgactcaag   2460

agccagtgaa gaggacagca aagtcagcga agggggctgg acaaaagtgg aataccggaa   2520

aaagccccac aggccatctc ccgccaaaac caataaagag agagccagag gggaccaccg   2580

tggatggaga aacttttgat gaattgaact acatagcttt tctaagcagg ttaaaaaaaa   2640

aaaaaaaaag aaatgtaatg gtttttgata atatgatccc ttcagattga attaacgaaa   2700

agacaacact tccagttttt ggattgggaa ataccttcta attgagacta tagccaaacc   2760

agggccaaaa ttatggatat tggtcaccca gtgatcataa ctaggcttga aaatcactac   2820

acatattttc tgccttgagt gaacattttt agaggaaagg ttatgccatc tttttaccct   2880

aaccactgat attctggtta gcagggccag gacaagggga aggaaaatga ggtcaacaaa   2940

aaaatcaaat ttttaggaaa agataagatg aatgttactg atttttcctt ttggctgagg   3000

ctgcaatatg gcctggcaag gcactgttac tgatcttgtc tttaacattt tgatattttg   3060

ttcatcataa tttttgcatt tattttttta aatattgcat taaaatatca tttagcttga   3120

ttatcgagtt ttttggtttg aggttttttg ttgcttcttt tttcttttct ttctttcccc   3180

ctcttttttt tggatgtccc cttaaatttt gtgcccaagg caggtacctc actcatctca   3240

tccttggctc agccctgctg gttagtattt agtatttatt ttagtaagat atttgtgtct   3300

gtatgatggt cagagttgaa ctgatctggc ttgtcatttt tcagtaataa aaaaagttac   3360

tgaatttaat gttgaatatg atgcatatct cattcattac gatttatcag aaaccaaaga   3420

tttaaattgc ctagatttgt ggttctttct cttcctaagt tcccagcgac tgctttcaaa   3480

tactattttc taaatttcac caaaggagca aagaggataa aacaacactc cataaaggcc   3540

tcttgggatg tcagaaatct aaaatctaaa agaaaacaga cacagagcaa gacaataaca   3600

tcacaagcta aaagccagag aaatttaaaa ttaccaacat ccttgttgga gtaagacagt   3660

aaatatcagc cttgcagcaa gacagctctg agcagctgtg ggcaaagagg taaaccagtg   3720

ggggtgcaag gagactgtct gcagcttagg gcagaaatgg tgggatccaa cttgtgaaat   3780

gcttcatgtt ttacaaacca aaaagtcagg tagcaacaaa cttattgtat gtcaaatcaa   3840

taaatgttac tttcaatatt c                                             3861


<210>  8744
<211>  800
<212>  PRT
<213>  Homosapiens

<400>  8744

Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn 
    50                  55                  60                  


Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile 
65                  70                  75                  80  


Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser 
                85                  90                  95      


Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr 
            100                 105                 110         


Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys 
        115                 120                 125             


Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp 
    130                 135                 140                 


Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His 
145                 150                 155                 160 


Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu 
                165                 170                 175     


Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr 
            180                 185                 190         


Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly 
        195                 200                 205             


Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg 
    210                 215                 220                 


Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His 
225                 230                 235                 240 


Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile 
                245                 250                 255     


Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys 
            260                 265                 270         


Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu 
        275                 280                 285             


Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys 
    290                 295                 300                 


Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln 
305                 310                 315                 320 


Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Pro Ser Phe Glu Ile 
                325                 330                 335     


Gly Ala Trp Thr Glu Asp Asp Val Tyr Cys Trp Val Gln Gln Leu Val 
            340                 345                 350         


Arg Lys Gly Asp Ser Ser Ala Glu Met Ser Val Tyr Ala Ser Leu Phe 
        355                 360                 365             


Lys Glu Asn Asn Ile Thr Gly Lys Arg Leu Leu Leu Leu Glu Glu Glu 
    370                 375                 380                 


Asp Leu Lys Asp Met Gly Ile Val Ser Lys Gly His Ile Ile His Phe 
385                 390                 395                 400 


Lys Ser Ala Ile Glu Lys Leu Thr His Asp Tyr Ile Asn Leu Phe His 
                405                 410                 415     


Phe Pro Pro Leu Ile Lys Asp Ser Gly Gly Glu Pro Glu Glu Asn Glu 
            420                 425                 430         


Glu Lys Ile Val Asn Leu Glu Leu Val Phe Gly Phe His Leu Lys Pro 
        435                 440                 445             


Gly Thr Gly Pro Gln Asp Cys Lys Trp Lys Met Tyr Met Glu Met Asp 
    450                 455                 460                 


Gly Asp Glu Ile Ala Ile Thr Tyr Ile Lys Asp Val Thr Phe Asn Thr 
465                 470                 475                 480 


Asn Leu Pro Asp Ala Glu Ile Leu Lys Met Thr Lys Pro Pro Phe Val 
                485                 490                 495     


Met Glu Lys Trp Ile Val Gly Ile Ala Lys Ser Gln Thr Val Glu Cys 
            500                 505                 510         


Thr Val Thr Tyr Glu Ser Asp Val Arg Thr Pro Lys Ser Thr Lys His 
        515                 520                 525             


Val His Ser Ile Gln Trp Ser Arg Thr Lys Pro Gln Asp Glu Val Lys 
    530                 535                 540                 


Ala Val Gln Leu Ala Ile Gln Thr Leu Phe Thr Asn Ser Asp Gly Asn 
545                 550                 555                 560 


Pro Gly Ser Arg Ser Asp Ser Ser Ala Asp Cys Gln Trp Leu Asp Thr 
                565                 570                 575     


Leu Arg Met Arg Gln Ile Ala Ser Asn Thr Ser Leu Gln Arg Ser Gln 
            580                 585                 590         


Ser Asn Pro Ile Leu Gly Ser Pro Phe Phe Ser His Phe Asp Gly Gln 
        595                 600                 605             


Asp Ser Tyr Ala Ala Ala Val Arg Arg Pro Gln Val Pro Ile Lys Tyr 
    610                 615                 620                 


Gln Gln Ile Thr Pro Val Asn Gln Ser Arg Ser Ser Ser Pro Thr Gln 
625                 630                 635                 640 


Tyr Gly Leu Thr Lys Asn Phe Ser Ser Leu His Leu Asn Ser Arg Asp 
                645                 650                 655     


Ser Gly Phe Ser Ser Gly Asn Thr Asp Thr Ser Ser Glu Arg Gly Arg 
            660                 665                 670         


Tyr Ser Asp Arg Ser Arg Asn Lys Tyr Gly Arg Gly Ser Ile Ser Leu 
        675                 680                 685             


Asn Ser Ser Pro Arg Gly Arg Tyr Ser Gly Lys Ser Gln His Ser Thr 
    690                 695                 700                 


Pro Ser Arg Gly Arg Tyr Pro Gly Lys Phe Tyr Arg Val Ser Gln Ser 
705                 710                 715                 720 


Ala Leu Asn Pro His Gln Ser Pro Asp Phe Lys Arg Ser Pro Arg Asp 
                725                 730                 735     


Leu His Gln Pro Asn Thr Ile Pro Gly Met Pro Leu His Pro Glu Thr 
            740                 745                 750         


Asp Ser Arg Ala Ser Glu Glu Asp Ser Lys Val Ser Glu Gly Gly Trp 
        755                 760                 765             


Thr Lys Val Glu Tyr Arg Lys Lys Pro His Arg Pro Ser Pro Ala Lys 
    770                 775                 780                 


Thr Asn Lys Glu Arg Ala Arg Gly Asp His Arg Gly Trp Arg Asn Phe 
785                 790                 795                 800 


<210>  8745
<211>  6087
<212>  DNA
<213>  Homosapiens

<400>  8745
gcggaatgtt caactcctaa ctgcagcgga aacgtgggag ccgcgcgggc cgctgtcgtc     60

ccaacccccg ccgccctcgt cgcgcgcggg gcctccgcgc ccccggctgc tgctcacgcc    120

ccgcccggga gccagatttt gtggaagtat aatactttgt cattatgaga tgtcgtctct    180

cggtgcctcc tttgtgcaaa ttaaatttga tgacttgcag ttttttgaaa actgcggtgg    240

aggaagtttt gggagtgttt atcgagccaa atggatatca caggacaagg aggtggctgt    300

aaagaagctc ctcaaaatag agaaagaggt aattcttcca aaaccacatc taagagaagg    360

gggaagaaag tcaacatggc tctggggttc agtgattttg acttgtcaga aggtgacgat    420

gatgatgatg atgacggtga ggaggaggat aatgacatgg ataatagtga atgaaagcag    480

aaagcaaagt aataaaatca caaatgtttg gaaaacacaa aagtaacttg tttatctcag    540

tctgtacaaa aacagtaagg aggcagaaag ccaagcactg catttttagg ccaatcacat    600

ttacatgacc gtaatttctt atcaattcta cttttatttt tgcttacaga aaaacggggg    660

gagaattaag ccaaagaagt atatttatga atcagcaaat gtggtgcctg attatagaaa    720

tttgtgatcc tatatacaat ataggacttt taaagttgtg acattctggc tttttctttt    780

aatgaatact ttttagtttg tatttgactt tatttccttt attcaaatca tttttaaaaa    840

cttacatttt gaacaaacac tcttaactcc taattgttct ttgacacgta gtaattctgt    900

gacatacttt ttttttctta tagcaataca ctgtaatatc agaaatggtt ggcctgagca    960

acctagtaag acctcgtctc tactaataat taaaaaacta gctggcatgg tagcacacac   1020

ctgtagtccc agatacttgg gaggccaagg caggaggatt gcttgagacc tagcaatcag   1080

tcagggctgc agtgagccat gatggcacca ctgcactcta gcctgggcaa gagaacaaga   1140

tcctgtctca aaaaacaaaa aaaagaaaga attgatagta caaaatccaa caacaatact   1200

gagatgatct aagaaggtta taacaaaatg ctcttcagaa atacctaagt gctgagaatt   1260

tttagtacta aagagcacag ctgctcaaag taaagcctga gcagtgttct cagtaatgta   1320

tttgaaggaa aaataccctg atttgaaacc aacagcagat gttgcaaact ttcataccac   1380

tgctggccat ggaagcctct taacaacaca ctgtcattta aggctgtgct tgtgctttat   1440

acaaagagaa agaggtggtc ttaaggggat gcttccaggg gggtgagttc atgcctctcc   1500

tgtattttcc agcaagtggg gtatgtgtgg tggtttgttt tttagagggg cataataatc   1560

caggattcta agcatatgct cagctatttt aaagaggaaa ttaaatatta taaaagaaat   1620

agtaaagata agttatcctc acttaggcaa aagcacaggt cctttccata tcaagtttag   1680

cctaccaggg ttgttttttg ttttaaccct gcttaataat gttggtgttt tagaagtaga   1740

tacaggcact gctctgaaaa cctggctagc caaggatatt ctcagaatgt tatcacctgt   1800

ttgtcaaagc ttgtttaaat tataaaacac ttttaattat atatatgagg caaaagaact   1860

aagacttttt tcaaactaaa ttagaaagga gtgtcattat ttgactgtta aaccaaaata   1920

tttttggtgg gtctttttat ggaagtttaa agaaaggaca tcatcataga tatgatctaa   1980

cagtatttct aactatattt gatcattaaa agcctcttgg aatttgaagc gtgacgtgtt   2040

tctaatgccc cttgagaggt gaaaaatacc acataatgat cagtatgctg tgccagcttc   2100

atttggggag aaataactag tagaaagttc tgggtgtgag gtgtacagca gtctaggtgg   2160

catagtgatg aagaaaggga tcagagtctg actgtcactc agaatcctgg gctcagttgc   2220

ttgacaacct tgggaaaatt gttttatctt tgtgcgtctg tttgctgatc ttcagcgtgg   2280

gaataataac agtacctact tgaaaggatc attgtgcgga ttaaaagaaa taatatatgt   2340

aaagcacttt aacacagcac caggcccacg gaaagtggct aatgttagct actatgaatg   2400

gtgccagtga agacactgaa aaataagtga tttcagtaac cttctggaaa gctatcagtt   2460

tcaaataata ttttctctgt agtatgagat gaaattaaaa gtggatagct ttcaggaaag   2520

ataaagagaa catgcttaga atgtaagcta aacagatttt ttctgttgct ctttgaaaac   2580

tatgagccct ggccagctta acctggtctg aggtgagact aaacacaaaa acagtagata   2640

aatctctccc taaaagatgg attcccccac atacccatgc tactagtttc tctgtctatt   2700

cacacatatg tacaaataca tgaacacagc ctgtctgtgc tcagacatag agaagtacta   2760

cctgacttga gtcaatgcac ccaagaagaa aagcttggag tagagcagaa gggagggctt   2820

gggactcctg tctttccagc atgccctggg gtgcagtggt cagccacctg aagagagagc   2880

caatagcatg gggtttacaa ggcaaagata gtcattcatt caacacatat tcatagagct   2940

ccttctctgt gccagacact gttctggaag atagctagat gaaaatcttt gcactcacag   3000

agcttacatg ccagtgagtg aagatcgatg ataaataaag caaatgcatc atatgttcac   3060

atttgataag tatatgccaa aaaatgaagc cgggaaggag gacaaggccc atgggtgggt   3120

gttgaggttt ttaaagtgtg gtcaggaaag gccccactga taaggtaaca tttgagcaag   3180

tctgaaaaag gcaaggggat ctttggggct aacttcggga tccctgcact ttatgtaaga   3240

atgtaaacct ggagtctcat ttaagaatga tcagcaatac gtttagaaca tatgaactga   3300

atgaaatgga cattttttct taatttatgt ataaatccat atgattatac ataaagttct   3360

gatgcattaa taaaagcagc caaatagggc caaagagaaa aataacagga ctctgtactg   3420

gacctaactt tatcattaat taggtaatat tttcctcatt tctttactgc tgccattttc   3480

ctcaccagta ttccagagat ggtcatagct cattactcta ccaccaagaa cctaaaagga   3540

attagaatac agcagaattg gcctcagtga agagcttaaa attgttctcc tcgtagaact   3600

ggactattga tcattaccac gtgacgttgg ctctattact ttctgttccc aatgtccttc   3660

tagtggtttg aaaatgttaa aacatcccta aaatctaaat catataatca gaattctata   3720

gtgtcccact ctatctgtaa agatcatttg gaagacttta gactctatta attttaaaag   3780

gaatatttat tagccatatg cagaatttct aatgatgata ttgtacagct tctaattcac   3840

ttttcagatc agtgtttgaa atggcaatta tcagtgttgg atttagttcc aactacttga   3900

tttacaaaaa tgtacattta gaggttaaaa gaaacagtga gaaatgtaaa cattcaaaat   3960

gataattgaa tctctcagtt gtgggaataa ttatcagaga catgcaactg aaaatgtctc   4020

acctttcatc tttttttctt aattcataaa gttatcttgt agaatttgat gagaccctcc   4080

ctagtcattc tcaactgggg cggtgctgtc accgaatggt gtttgagagt gttggggcta   4140

gggcacattt ttggttgtca cagcaactgg ggtggcattt gctgcccagt gccaggaata   4200

gtaacattat gaatgccagg gacagtgtgc tcagtaaagt cttccatcca aaaggggcag   4260

ggcacggtgg ctcacgcctg taatcccagc actttgggag gccaaggtgg gcggatcacc   4320

tgatgtcagg ggttcgagac cagcctggcc aacatggtga aaccctgttg ctactaaaaa   4380

tacaaaaatt ggctgggtgt ggtgtcacat gccagtaacc ccagctacta gggaggctga   4440

ggcaggagaa tcacttgaac ccgggaggca gaggttgcag tgagctgaga ttgcaccact   4500

acactccagc ctggatgaca gagtgagact tcatctcaaa aaaaaaaaaa aacaaaaaaa   4560

aacaacccgg tagcattgtc ccttccccac tgacaaactt atcaaatcca gaagctttag   4620

agtttcgtct ctaattattt ttctcctgaa caaaattacc caagtcaaaa caaaatgtat   4680

ttttagaatt acggcagcat acgacctgaa ttttgtgagt ttcgtggctt tatcttaaat   4740

caccatttcc ctaaaaatgg tttctttctc cttagaaatg ctggtggcaa cttgatgaaa   4800

cagccaaatg caccagggca ggtcactttc ccattacact gattccacaa ttaaaaaaaa   4860

aaaagaaaaa aaactcattg agatagctac agttctatag gttaatttaa agcctccttt   4920

ttctactcat ttttgaaagc aaaattacat tttactattt tacataacca gtgaaaagac   4980

gttgaaagcc tacagctcac tgtttttggt gctctggaaa tgttgagggt gggtttttaa   5040

ccagtgattt ttaacgtgca gtgaatttgt tagactttta aacaccagct aaggtagtca   5100

aacttgatcc ccattaaaaa tcaaggaatt aggggtcggg ggagggttta ggagtgatcc   5160

agaatgacct cccagaatta ctgtgcgtac aactttattt ttcagagttt tcattggaat   5220

ggtaagagtt ttatgaaaga cagttttaaa acttattctg agttaaatat taatacttta   5280

aaaaattatt gtactagact tattgcagcc ttttgaaagt agcagagttt catcatacca   5340

catatataac agagcataaa ttttctataa tcaggcacct tttgctgctt ttgagtaaga   5400

ctgttttcct gtttaagtgt taagcatcgc cagacataaa aatctattct ctcctctcga   5460

ttgtagcata gcctgacagc tctagataca gcatttctat gatgaaaaat gagtatccat   5520

caggaaatct agaagactag ccgtgttttc tcagactcca cctttgtttg cactctgttg   5580

cctgtgagga gctttctggc atgtgattat ttacttcaaa actagagttc caagcaccta   5640

cattaattat tttatattgt gtgcagaata gtatatcttt taatgtcaga tatgatacac   5700

tgcacatatt gcttttgcac tcttaaaatt tttgtactaa ataatagaaa atatttatat   5760

tctttgagtg tgagctttga atagatggca ttatcacttt attgtttttt taacaaaaac   5820

tttttctcaa ttattctatt gcaatgttat tctgagcaag tcctatgcca aatatcttgt   5880

ataatgtttg tatggaagat taaattttac tcttgtgtgg taagactatt tcagttactg   5940

attttatagt tggaatttga tattccagca caaagtccac agtgtattca gaaatccaag   6000

ttggtgtcat acatttcatt ttgatgtgaa cttttctttg ctttcctttg ttctaagact   6060

ccattttgca ataaacgttt tgacagt                                       6087


<210>  8746
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  8746

Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Val Ile Leu Pro Lys Pro His Leu Arg Glu Gly 
    50                  55                  60                  


Gly Arg Lys Ser Thr Trp Leu Trp Gly Ser Val Ile Leu Thr Cys Gln 
65                  70                  75                  80  


Lys Val Thr Met Met Met Met Met Thr Val Arg Arg Arg Ile Met Thr 
                85                  90                  95      


Trp Ile Ile Val Asn Glu Ser Arg Lys Gln Ser Asn Lys Ile Thr Asn 
            100                 105                 110         


Val Trp Lys Thr Gln Lys 
        115             


<210>  8747
<211>  6102
<212>  DNA
<213>  Homosapiens

<400>  8747
gcggaatgtt caactcctaa ctgcagcgga aacgtgggag ccgcgcgggc cgctgtcgtc     60

ccaacccccg ccgccctcgt cgcgcgcggg gcctccgcgc ccccggctgc tgctcacgcc    120

ccgcccggga gccagatttt gtggaagtat aatactttgt cattatgaga tgtcgtctct    180

cggtgcctcc tttgtgcaaa ttaaatttga tgacttgcag ttttttgaaa actgcggtgg    240

aggaagtttt gggagtgttt atcgagccaa atggatatca caggacaagg aggtggctgt    300

aaagaagctc ctcaaaatag agaaagaggt aattcttcca aaaccacatc taagagaagg    360

gggaagaaag tcaacatggc tctggggttc agtgattttg acttgtcaga aggtgacgat    420

gatgatgatg atgacggtga ggaggaggat aatgacatgg ataatagtga atgaaagcag    480

aaagcaaagt aataaaatca caaatgtttg gaaaacacaa aagtaacttg tttatctcag    540

tctgtacaaa aacagtaagg aggcagaaag ccaagcactg catttttagg ccaatcacat    600

ttacatgacc gtaatttctt atcaattcta cttttatttt tgcttacaga aaaacggggg    660

gagaattaag ccaaagaagt atatttatga atcagcaaat gtggtgcctg attatagaaa    720

tttgtgatcc tatatacaat ataggacttt taaagttgtg acattctggc tttttctttt    780

aatgaatact ttttagtttg tatttgactt tatttccttt attcaaatca tttttaaaaa    840

cttacatttt gaacaaacac tcttaactcc taattgttct ttgacacgta gtaattctgt    900

gacatacttt ttttttctta tagcaataca ctgtaatatc agaaatggtt ggcctgagca    960

acctagtaag acctcgtctc tactaataat taaaaaacta gctggcatgg tagcacacac   1020

ctgtagtccc agatacttgg gaggccaagg caggaggatt gcttgagacc tagcaatcag   1080

tcagggctgc agtgagccat gatggcacca ctgcactcta gcctgggcaa gagaacaaga   1140

tcctgtctca aaaaacaaaa aaaagaaaga attgatagta caaaatccaa caacaatact   1200

gagatgatct aagaaggtta taacaaaatg ctcttcagaa atacctaagt gctgagaatt   1260

tttagtacta aagagcacag ctgctcaaag taaagcctga gcagtgttct cagtaatgta   1320

tttgaaggaa aaataccctg atttgaaacc aacagcagat gttgcaaact ttcataccac   1380

tgctggccat ggaagcctct taacaacaca ctgtcattta aggctgtgct tgtgctttat   1440

acaaagagaa agaggtggtc ttaaggggat gcttccaggg gggtgagttc atgcctctcc   1500

tgtattttcc agcaagtggg gtatgtgtgg tggtttgttt tttagagggg cataataatc   1560

caggattcta agcatatgct cagctatttt aaagaggaaa ttaaatatta taaaagaaat   1620

agtaaagata agttatcctc acttaggcaa aagcacaggt cctttccata tcaagtttag   1680

cctaccaggg ttgttttttg ttttaaccct gcttaataat gttggtgttt tagaagtaga   1740

tacaggcact gctctgaaaa cctggctagc caaggatatt ctcagaatgt tatcacctgt   1800

ttgtcaaagc ttgtttaaat tataaaacac ttttaattat atatatgagg caaaagaact   1860

aagacttttt tcaaactaaa ttagaaagga gtgtcattat ttgactgtta aaccaaaata   1920

tttttggtgg gtctttttat ggaagtttaa agaaaggaca tcatcataga tatgatctaa   1980

cagtatttct aactatattt gatcattaaa agcctcttgg aatttgaagc gtgacgtgtt   2040

tctaatgccc cttgagaggt gaaaaatacc acataatgat cagtatgctg tgccagcttc   2100

atttggggag aaataactag tagaaagttc tgggtgtgag gtgtacagca gtctaggtgg   2160

catagtgatg aagaaaggga tcagagtctg actgtcactc agaatcctgg gctcagttgc   2220

ttgacaacct tgggaaaatt gttttatctt tgtgcgtctg tttgctgatc ttcagcgtgg   2280

gaataataac agtacctact tgaaaggatc attgtgcgga ttaaaagaaa taatatatgt   2340

aaagcacttt aacacagcac caggcccacg gaaagtggct aatgttagct actatgaatg   2400

gtgccagtga agacactgaa aaataagtga tttcagtaac cttctggaaa gctatcagtt   2460

tcaaataata ttttctctgt agtatgagat gaaattaaaa gtggatagct ttcaggaaag   2520

ataaagagaa catgcttaga atgtaagcta aacagatttt ttctgttgct ctttgaaaac   2580

tatgagccct ggccagctta acctggtctg aggtgagact aaacacaaaa acagtagata   2640

aatctctccc taaaagatgg attcccccac atacccatgc tactagtttc tctgtctatt   2700

cacacatatg tacaaataca tgaacacagc ctgtctgtgc tcagacatag agaagtacta   2760

cctgacttga gtcaatgcac ccaagaagaa aagcttggag tagagcagaa gggagggctt   2820

gggactcctg tctttccagc atgccctggg gtgcagtggt cagccacctg aagagagagc   2880

caatagcatg gggtttacaa ggcaaagata gtcattcatt caacacatat tcatagagct   2940

ccttctctgt gccagacact gttctggaag atagctagat gaaaatcttt gcactcacag   3000

agcttacatg ccagtgagtg aagatcgatg ataaataaag caaatgcatc atatgttcac   3060

atttgataag tatatgccaa aaaatgaagc cgggaaggag gacaaggccc atgggtgggt   3120

gttgaggttt ttaaagtgtg gtcaggaaag gccccactga taaggtaaca tttgagcaag   3180

tctgaaaaag gcaaggggat ctttggggct aacttcggga tccctgcact ttatgtaaga   3240

atgtaaacct ggagtctcat ttaagaatga tcagcaatac gtttagaaca tatgaactga   3300

atgaaatgga cattttttct taatttatgt ataaatccat atgattatac ataaagttct   3360

gatgcattaa taaaagcagc caaatagggc caaagagaaa aataacagga ctctgtactg   3420

gacctaactt tatcattaat taggtaatat tttcctcatt tctttactgc tgccattttc   3480

ctcaccagta ttccagagat ggtcatagct cattactcta ccaccaagaa cctaaaagga   3540

attagaatac agcagaattg gcctcagtga agagcttaaa attgttctcc tcgtagaact   3600

ggactattga tcattaccac gtgacgttgg ctctattact ttctgttccc aatgtccttc   3660

tagtggtttg aaaatgttaa aacatcccta aaatctaaat catataatca gaattctata   3720

gtgtcccact ctatctgtaa agatcatttg gaagacttta gactctatta attttaaaag   3780

gaatatttat tagccatatg cagaatttct aatgatgata ttgtacagct tctaattcac   3840

ttttcagatc agtgtttgaa atggcaatta tcagtgttgg atttagttcc aactacttga   3900

tttacaaaaa tgtacattta gaggttaaaa gaaacagtga gaaatgtaaa cattcaaaat   3960

gataattgaa tctctcagtt gtgggaataa ttatcagaga catgcaactg aaaatgtctc   4020

acctttcatc tttttttctt aattcataaa gttatcttgt agaatttgat gagaccctcc   4080

ctagtcattc tcaactgggg cggtgctgtc accgaatggt gtttgagagt gttggggcta   4140

gggcacattt ttggttgtca cagcaactgg ggtggcattt gctgcccagt gccaggaata   4200

gtaacattat gaatgccagg gacagtgtgc tcagtaaagt cttccatcca aaaggggcag   4260

ggcacggtgg ctcacgcctg taatcccagc actttgggag gccaaggtgg gcggatcacc   4320

tgatgtcagg ggttcgagac cagcctggcc aacatggtga aaccctgttg ctactaaaaa   4380

tacaaaaatt ggctgggtgt ggtgtcacat gccagtaacc ccagctacta gggaggctga   4440

ggcaggagaa tcacttgaac ccgggaggca gaggttgcag tgagctgaga ttgcaccact   4500

acactccagc ctggatgaca gagtgagact tcatctcaaa aaaaaaaaaa aacaaaaaaa   4560

aacaacccgg tagcattgtc ccttccccac tgacaaactt atcaaatcca gaagctttag   4620

agtttcgtct ctaattattt ttctcctgaa caaaattacc caagtcaaaa caaaatgtat   4680

ttttagaatt acggcagcat acgacctgaa ttttgtgagt ttcgtggctt tatcttaaat   4740

caccatttcc ctaaaaatgg tttctttctc cttagaaatg ctggtggcaa cttgatgaaa   4800

cagccaaatg caccagggca ggtcactttc ccattacact gattccacaa ttaaaaaaaa   4860

aaaagaaaaa aaactcattg agatagctac agttctatag gttaatttaa agcctccttt   4920

ttctactcat ttttgaaagc aaaattacat tttactattt tacataacca gtgaaaagac   4980

gttgaaagcc tacagctcac tgtttttggt gctctggaaa tgttgagggt gggtttttaa   5040

ccagtgattt ttaacgtgca gtgaatttgt tagactttta aacaccagct aaggtagtca   5100

aacttgatcc ccattaaaaa tcaaggaatt aggggtcggg ggagggttta ggagtgatcc   5160

agaatgacct cccagaatta ctgtgcgtac aactttattt ttcagagttt tcattggaat   5220

ggtaagagtt ttatgaaaga cagttttaaa acttattctg agttaaatat taatacttta   5280

aaaaattatt gtactagact tattgcagcc ttttgaaagt agcagagttt catcatacca   5340

catatataac agagcataaa ttttctataa tcaggcacct tttgctgctt ttgagtaaga   5400

ctgttttcct gtttaagtgt taagcatcgc cagacataaa aatctattct ctcctctcga   5460

ttgtagcata gcctgacagc tctagataca gcatttctat gatgaaaaat gagtatccat   5520

caggaaatct agaagactag ccgtgttttc tcagactcca cctttgtttg cactctgttg   5580

cctgtgagga gctttctggc atgtgattat ttacttcaaa actagagttc caagcaccta   5640

cattaattat tttatattgt gtgcagaata gtatatcttt taatgtcaga tatgatacac   5700

tgcacatatt gcttttgcac tcttaaaatt tttgtactaa ataatagaaa atatttatat   5760

tctttgagtg tgagctttga atagatggca ttatcacttt attgtttttt taacaaaaac   5820

tttttctcaa ttattctatt gcaatgttat tctgagcaag tcctatgcca aatatcttgt   5880

ataatgtttg tatggaagat taaattttac tcttgtgtgg taagactatt tcagttactg   5940

attttatagt tggaatttga tattccagca caaagtccac agtgtattca gaaatccaag   6000

ttggtgtcat acatttcatt ttgatgtgaa cttttctttg ctttcctttg ttctaagact   6060

ccattttgca ataaacgttt tgacagtaaa tccctttgtt ac                      6102


<210>  8748
<211>  118
<212>  PRT
<213>  Homosapiens

<400>  8748

Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu 
1               5                   10                  15      


Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg 
            20                  25                  30          


Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu 
        35                  40                  45              


Lys Ile Glu Lys Glu Val Ile Leu Pro Lys Pro His Leu Arg Glu Gly 
    50                  55                  60                  


Gly Arg Lys Ser Thr Trp Leu Trp Gly Ser Val Ile Leu Thr Cys Gln 
65                  70                  75                  80  


Lys Val Thr Met Met Met Met Met Thr Val Arg Arg Arg Ile Met Thr 
                85                  90                  95      


Trp Ile Ile Val Asn Glu Ser Arg Lys Gln Ser Asn Lys Ile Thr Asn 
            100                 105                 110         


Val Trp Lys Thr Gln Lys 
        115             


<210>  8749
<211>  731
<212>  DNA
<213>  Homosapiens

<400>  8749
aggcttccat tgacgaccag ctttggctgt tccaactcac cacagcctct gaaagaccca     60

tgctctcttt ggattgcttg gtacctgcag cacgtttcca tgcctgggag gtaaggacca    120

caagtctcag aagagtagga agtgcccagc atcacacagg aagcaagtta cagaaccaag    180

ggctctgttc ataaactgtt caacatcttt tatcacataa ggggaggtgc ccgcaacgat    240

ggcctgctgc agaatacaga gtggcttttt catgtttgat gggttgtaag aaacaaaaag    300

ccaactatgg catctatgaa gactatgcaa cagagactat ttatattctg ggataatcta    360

gcaaatgagc tgcgcatcaa aataatggat tagtggttta aaaacgtgtt cactgttaaa    420

aggaaaacat gaaaatgatg aaagctaaaa taatggtcca tcatacaaaa gtatatcttt    480

ttacactatt aaaaccaaca taagccattt attttcagta aatataattg gataacaatc    540

gttaatttaa actgtattga ttttattttt gtttaattga aaaattggtt ttgaatttac    600

ctgtatatga gagttataag gagttaattc ttagttttat gtttatgtat atttaagtta    660

cacagaaata atttcagtca acatgtgaaa tctggaagac taaaattttc tatataaaag    720

atctacacat t                                                         731


<210>  8750
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  8750

Met Leu Ser Leu Asp Cys Leu Val Pro Ala Ala Arg Phe His Ala Trp 
1               5                   10                  15      


Glu Val Arg Thr Thr Ser Leu Arg Arg Val Gly Ser Ala Gln His His 
            20                  25                  30          


Thr Gly Ser Lys Leu Gln Asn Gln Gly Leu Cys Ser 
        35                  40                  


<210>  8751
<211>  2535
<212>  DNA
<213>  Homosapiens

<400>  8751
gtggcaactt ggtcgggtct gcttccgcgc tgtggaggtt ttgtttttta ctctttgcag     60

taaatcttgc tgctgctcac tctttgggtc cgcactgctt ttgtgagctg taacactcac    120

ggagaaggtc tgcaggttca tttctgagcc agcgagacca ccagcccgcc aggaggaaga    180

cgctgccgaa catcagaagg aacaaactcc aaacacgccg cctttaagaa ctgtaacacc    240

tggagggtcc gcggcttcat gaagtcgcag agaccaagaa cccaccaatt ccggacacaa    300

atgcatcatt gcactccagc ctgggtgaca gagtgaaacc ctgtctcaaa aataagcttc    360

cattgacgac cagctttggc tgttccaact caccacagcc tctgaaagac ccatgctctc    420

tttggattgc ttggtacctg cagcacgttt ccatgcctgg gagggagaat aagagtaagt    480

gaacagttta ctcttactgg aacattccaa tgctcttaca gataataact aagtgaatga    540

aaacaaaaag ttcaggcatt cactggcaaa atccaactct gaacaggtat ggaggtgggt    600

ctggatttgg ctcaacattt cacttcgcta ctcgtctgaa atgcacctca gagcaaggga    660

ggcagcaatc aggtaacgca cgtcatggtg agagtacttt ggtcaccacg ggaaacacaa    720

ccaaccaagt gttttgccaa gagacacaga tcggaacgct catcacaaca ctgcatggct    780

cattcagtgc aggttgccac aggtctacag tcacatggtt aatgaaaatc caaaacagga    840

ccaacaggat gacacatttt ctgttcttaa tgctcattgc cattattgct agatctcact    900

ctgtagccca ggctggagtg tcgtggccag atctcggctc aatgcagctt tgacctcccc    960

agctcaagtg atcctcccac ctcagcctcc cgagttgagt aactgggacc acagctatgg   1020

tcagaaatca ggactgtcat tcagatctct ggttcacttc ttcattgaga cgagtgatgg   1080

tctttgaaag ccagacgctg tggcctgctg tcggggctac ccacctccac tccgccttgt   1140

tgtgtaggaa tgagttacac ttgtcaggaa ggctcgtgtc atttgacatg gactccagga   1200

ttgaaatgat ttgcttgaat gatggccgtt tctgaagaag agaaaataag taatcattcg   1260

ctgggactta agaaaggaga tatttaagag aaaacgtaga tactacaagc atagtaagga   1320

ccacaagtct cagaagagta ggaagtgccc agcatcacac aggaagcaag ttacagaacc   1380

aagggctctg ttcataaact gttcaacatc ttttatcaca taagggctca taggtccaac   1440

taactgaaag cctcaatttg tgggaagaag agaagcgagg ctggggacac agcacaaacg   1500

gtgtttacgc cactgaagtt cttttgaaat ggaaaggctc tgcatgaaga agcgaacagt   1560

tatgccactg cctcgccaat tccagtgagg agctcatctt caatgtagtg ttcaacgtag   1620

gtggcaaaac tgtaattttt cccttttttg aaactatttt ttcttctttt atttttgaaa   1680

ttctcatcta agcgacagtt tcttgtacta tagtgactcc tgctgggaga ggtaagttga   1740

agtagctgaa ggtctcttac agatatatca actcccggcc agtaaaaaag atgtcctaaa   1800

cgcaggagat ggagttaaac tgttccccta ccttggacgc aatggcttct ttcatcacta   1860

agaacaaacc cctaggtttt acaattgaga ctgagaaact agtacagtac ttgtacaatt   1920

tttgatctac agcatcacga cgtgaagctg caacaattag atgtaaaggg tccattcatg   1980

aggaataaca tcactttgac cctttgtgtt agctcctact gctaatcttt ccataagcgt   2040

gaacttactt tcaatttgaa gaagatgaaa aagtcttttg caaaacccca atactgtttt   2100

ctgatctatg tacctgaatg gagaaacgta gtcttacctc gtttttttcc actacaagcc   2160

aagctacttg taatccttcc aaacctttaa aggggacctc ccttgttagc atctcccaga   2220

gaacctggaa caaaaagaaa atggaatttt tatttttgta ctttatattt tttggtacat   2280

attactgaga ccttatctaa catgtaattg tatctaatta ccagacacaa ccaaccccaa   2340

ctgtagaaac ttgggcaaaa caattaagca cacaacttct tctatatatt aaatactttt   2400

tacgttcttt tttataaaga aaaaacctgg tttagaaatt aggacatcta gagccagact   2460

taaaatttta tgaaaccaat gggcctgact gatttaatgt catctcataa attatcagaa   2520

tttttatgtt ctcac                                                    2535


<210>  8752
<211>  138
<212>  PRT
<213>  Homosapiens

<400>  8752

Met Lys Thr Lys Ser Ser Gly Ile His Trp Gln Asn Pro Thr Leu Asn 
1               5                   10                  15      


Arg Tyr Gly Gly Gly Ser Gly Phe Gly Ser Thr Phe His Phe Ala Thr 
            20                  25                  30          


Arg Leu Lys Cys Thr Ser Glu Gln Gly Arg Gln Gln Ser Gly Asn Ala 
        35                  40                  45              


Arg His Gly Glu Ser Thr Leu Val Thr Thr Gly Asn Thr Thr Asn Gln 
    50                  55                  60                  


Val Phe Cys Gln Glu Thr Gln Ile Gly Thr Leu Ile Thr Thr Leu His 
65                  70                  75                  80  


Gly Ser Phe Ser Ala Gly Cys His Arg Ser Thr Val Thr Trp Leu Met 
                85                  90                  95      


Lys Ile Gln Asn Arg Thr Asn Arg Met Thr His Phe Leu Phe Leu Met 
            100                 105                 110         


Leu Ile Ala Ile Ile Ala Arg Ser His Ser Val Ala Gln Ala Gly Val 
        115                 120                 125             


Ser Trp Pro Asp Leu Gly Ser Met Gln Leu 
    130                 135             


<210>  8753
<211>  1198
<212>  DNA
<213>  Homosapiens

<400>  8753
gaaattgagg caactcttga gaggctaaag aaactagagc gtgatctcag ctttaaggag     60

caggagctta aagaacgaga aagacgttta aagatgtggg agcaaaagag tggaaagagt    120

cagcattcca ctccttcaag aggaagatac cctggaaagt tctacagggt ttctcagtca    180

gcactcaatc ctcaccagtc gcctgacttc aagagaagcc ccagggacct ccaccaaccc    240

aacaccatac cagggatgcc tttgcaccct gagactgact caagagccag tgaagaggac    300

agcaaagtca gcgaaggggg ctggacaaaa gtggaatacc ggaaaaagcc ccacaggcca    360

tctcccgcca aaaccaataa agagagagcc agaggggacc accgtggatg gagaaacttt    420

tgatgaattg aactacatag cttttctaag caggttaaaa aaaaaaaaaa aaagaaatgt    480

aatggttttt gataatatga tcccttcaga ttgaattaac gaaaagacaa cacttccagt    540

ttttggattg ggaaatacct tctaattgag actatagcca aaccagggcc aaaattatgg    600

atattggtca cccagtgatc ataactaggc ttgaaaatca ctacacatat tttctgcctt    660

gagtgaacat ttttagagga aaggttatgc catcttttta ccctaaccac tgatattctg    720

gttagcaggg ccaggacaag gggaaggaaa atgaggtcaa caaaaaaatc aaatttttag    780

gaaaagataa gatgaatgtt actgattttt ccttttggct gaggctgcaa tatggcctgg    840

caaggcactg ttactgatct tgtctttaac attttgatat tttgttcatc ataatttttg    900

catttatttt tttaaatatt gcattaaaat atcatttagc ttgattatcg agttttttgg    960

tttgaggttt tttgttgctt cttttttctt ttctttcttt ccccctcttt tttttggatg   1020

tccccttaaa ttttgtgccc aaggcaggta cctcactcat ctcatccttg gctcagccct   1080

gctggttagt atttagtatt tattttagta agatatttgt gtctgtatga tggtcagagt   1140

tgaactgatc tggcttgtca tttttcagta ataaaaaaag ttactgaatt taatgttg     1198


<210>  8754
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  8754

Met Trp Glu Gln Lys Ser Gly Lys Ser Gln His Ser Thr Pro Ser Arg 
1               5                   10                  15      


Gly Arg Tyr Pro Gly Lys Phe Tyr Arg Val Ser Gln Ser Ala Leu Asn 
            20                  25                  30          


Pro His Gln Ser Pro Asp Phe Lys Arg Ser Pro Arg Asp Leu His Gln 
        35                  40                  45              


Pro Asn Thr Ile Pro Gly Met Pro Leu His Pro Glu Thr Asp Ser Arg 
    50                  55                  60                  


Ala Ser Glu Glu Asp Ser Lys Val Ser Glu Gly Gly Trp Thr Lys Val 
65                  70                  75                  80  


Glu Tyr Arg Lys Lys Pro His Arg Pro Ser Pro Ala Lys Thr Asn Lys 
                85                  90                  95      


Glu Arg Ala Arg Gly Asp His Arg Gly Trp Arg Asn Phe 
            100                 105                 


<210>  8755
<211>  1685
<212>  DNA
<213>  Homosapiens

<400>  8755
gaaattgagg caactcttga gaggctaaag aaactagagc gtgatctcag ctttaaggag     60

caggagctta aagaacgaga aagacgttta aagatgtggg agcaaaagag tggaaagagt    120

cagcattcca ctccttcaag aggaagatac cctggaaagt tctacagggt ttctcagtca    180

gcactcaatc ctcaccagtc gcctgacttc aagagaagcc ccagggacct ccaccaaccc    240

aacaccatac cagggatgcc tttgcaccct gagactgact caagagccag tgaagaggac    300

agcaaagtca gcgaaggggg ctggacaaaa gtggaatacc ggaaaaagcc ccacaggcca    360

tctcccgcca aaaccaataa agagagagcc agaggggacc accgtggatg gagaaacttt    420

tgatgaattg aactacatag cttttctaag caggttaaaa aaaaaaaaaa aaagaaatgt    480

aatggttttt gataatatga tcccttcaga ttgaattaac gaaaagacaa cacttccagt    540

ttttggattg ggaaatacct tctaattgag actatagcca aaccagggcc aaaattatgg    600

atattggtca cccagtgatc ataactaggc ttgaaaatca ctacacatat tttctgcctt    660

gagtgaacat ttttagagga aaggttatgc catcttttta ccctaaccac tgatattctg    720

gttagcaggg ccaggacaag gggaaggaaa atgaggtcaa caaaaaaatc aaatttttag    780

gaaaagataa gatgaatgtt actgattttt ccttttggct gaggctgcaa tatggcctgg    840

caaggcactg ttactgatct tgtctttaac attttgatat tttgttcatc ataatttttg    900

catttatttt tttaaatatt gcattaaaat atcatttagc ttgattatcg agttttttgg    960

tttgaggttt tttgttgctt cttttttctt ttctttcttt ccccctcttt tttttggatg   1020

tccccttaaa ttttgtgccc aaggcaggta cctcactcat ctcatccttg gctcagccct   1080

gctggttagt atttagtatt tattttagta agatatttgt gtctgtatga tggtcagagt   1140

tgaactgatc tggcttgtca tttttcagta ataaaaaaag ttactgaatt taatgttgaa   1200

tatgatgcat atctcattca ttacgattta tcagaaacca aagatttaaa ttgcctagat   1260

ttgtggttct ttctcttcct aagttcccag cgactgcttt caaatactat tttctaaatt   1320

tcaccaaagg agcaaagagg ataaaacaac actccataaa ggcctcttgg gatgtcagaa   1380

atctaaaatc taaaagaaaa cagacacaga gcaagacaat aacatcacaa gctaaaagcc   1440

agagaaattt aaaattacca acatccttgt tggagtaaga cagtaaatat cagccttgca   1500

gcaagacagc tctgagcagc tgtgggcaaa gaggtaaacc agtgggggtg caaggagact   1560

gtctgcagct tagggcagaa atggtgggat ccaacttgtg aaatgcttca tgttttacaa   1620

accaaaaagt caggtagcaa caaacttatt gtatgtcaaa tcaataaatg ttactttcaa   1680

tattc                                                               1685


<210>  8756
<211>  109
<212>  PRT
<213>  Homosapiens

<400>  8756

Met Trp Glu Gln Lys Ser Gly Lys Ser Gln His Ser Thr Pro Ser Arg 
1               5                   10                  15      


Gly Arg Tyr Pro Gly Lys Phe Tyr Arg Val Ser Gln Ser Ala Leu Asn 
            20                  25                  30          


Pro His Gln Ser Pro Asp Phe Lys Arg Ser Pro Arg Asp Leu His Gln 
        35                  40                  45              


Pro Asn Thr Ile Pro Gly Met Pro Leu His Pro Glu Thr Asp Ser Arg 
    50                  55                  60                  


Ala Ser Glu Glu Asp Ser Lys Val Ser Glu Gly Gly Trp Thr Lys Val 
65                  70                  75                  80  


Glu Tyr Arg Lys Lys Pro His Arg Pro Ser Pro Ala Lys Thr Asn Lys 
                85                  90                  95      


Glu Arg Ala Arg Gly Asp His Arg Gly Trp Arg Asn Phe 
            100                 105                 


<210>  8757
<211>  3748
<212>  DNA
<213>  Homosapiens

<400>  8757
tgctgatctt cagcgtggga ataataacag tacctacttg aaaggatcat tgtgcggatt     60

aaaagaaata atatatgtaa agcactttaa cacagcacca ggcccacgga aagtggctaa    120

tgttagctac tatgaatggt gccagtgaag acactgaaaa ataagtgatt tcagtaacct    180

tctggaaagc tatcagtttc aaataatatt ttctctgtag tatgagatga aattaaaagt    240

ggatagcttt caggaaagat aaagagaaca tgcttagaat gtaagctaaa cagatttttt    300

ctgttgctct ttgaaaacta tgagccctgg ccagcttaac ctggtctgag gtgagactaa    360

acacaaaaac agtagataaa tctctcccta aaagatggat tcccccacat acccatgcta    420

ctagtttctc tgtctattca cacatatgta caaatacatg aacacagcct gtctgtgctc    480

agacatagag aagtactacc tgacttgagt caatgcaccc aagaagaaaa gcttggagta    540

gagcagaagg gagggcttgg gactcctgtc tttccagcat gccctggggt gcagtggtca    600

gccacctgaa gagagagcca atagcatggg gtttacaagg caaagatagt cattcattca    660

acacatattc atagagctcc ttctctgtgc cagacactgt tctggaagat agctagatga    720

aaatctttgc actcacagag cttacatgcc agtgagtgaa gatcgatgat aaataaagca    780

aatgcatcat atgttcacat ttgataagta tatgccaaaa aatgaagccg ggaaggagga    840

caaggcccat gggtgggtgt tgaggttttt aaagtgtggt caggaaaggc cccactgata    900

aggtaacatt tgagcaagtc tgaaaaaggc aaggggatct ttggggctaa cttcgggatc    960

cctgcacttt atgtaagaat gtaaacctgg agtctcattt aagaatgatc agcaatacgt   1020

ttagaacata tgaactgaat gaaatggaca ttttttctta atttatgtat aaatccatat   1080

gattatacat aaagttctga tgcattaata aaagcagcca aatagggcca aagagaaaaa   1140

taacaggact ctgtactgga cctaactttc tcattactct accaccaaga acctaaaagg   1200

aattagaata cagcagaatt ggcctcagtg aagagcttaa aattgttctc ctcgtagaac   1260

tggactattg atcattacca cgtgacgttg gctctattac tttctgttcc caatgtcctt   1320

ctagtggttt gaaaatgtta aaacatccct aaaatctaaa tcatataatc agaattctat   1380

agtgtcccac tctatctgta aagatcattt ggaagacttt agactctatt aattttaaaa   1440

ggaatattta ttagccatat gcagaatttc taatgatgat attgtacagc ttctaattca   1500

cttttcagat cagtgtttga aatggcaatt atcagtgttg gatttagttc caactacttg   1560

atttacaaaa atgtacattt agaggttaaa agaaacagtg agaaatgtaa acattcaaaa   1620

tgataattga atctctcagt tgtgggaata attatcagag acatgcaact gaaaatgtct   1680

cacctttcat ctttttttct taattcataa agttatcttg tagaatttga tgagaccctc   1740

cctagtcatt ctcaactggg gcggtgctgt caccgaatgg tgtttgagag tgttggggct   1800

agggcacatt tttggttgtc acagcaactg gggtggcatt tgctgcccag tgccaggaat   1860

agtaacatta tgaatgccag ggacagtgtg ctcagtaaag tcttccatcc aaaaggggca   1920

gggcacggtg gctcacgcct gtaatcccag cactttggga ggccaaggtg ggcggatcac   1980

ctgatgtcag gggttcgaga ccagcctggc caacatggtg aaaccctgtt gctactaaaa   2040

atacaaaaat tggctgggtg tggtgtcaca tgccagtaac cccagctact agggaggctg   2100

aggcaggaga atcacttgaa cccgggaggc agaggttgca gtgagctgag attgcaccac   2160

tacactccag cctggatgac agagtgagac ttcatctcaa aaaaaaaaaa aaacaaaaaa   2220

aaacaacccg gtagcattgt cccttcccca ctgacaaact tatcaaatcc agaagcttta   2280

gagtttcgtc tctaattatt tttctcctga acaaaattac ccaagtcaaa acaaaatgta   2340

tttttagaat tacggcagca tacgacctga attttgtgag tttcgtggct ttatcttaaa   2400

tcaccatttc cctaaaaatg gtttctttct ccttagaaat gctggtggca acttgatgaa   2460

acagccaaat gcaccagggc aggtcacttt cccattacac tgattccaca attaaaaaaa   2520

aaaaagaaaa aaaactcatt gagatagcta cagttctata ggttaattta aagcctcctt   2580

tttctactca tttttgaaag caaaattaca ttttactatt ttacataacc agtgaaaaga   2640

cgttgaaagc ctacagctca ctgtttttgg tgctctggaa atgttgaggg tgggttttta   2700

accagtgatt tttaacgtgc agtgaatttg ttagactttt aaacaccagc taaggtagtc   2760

aaacttgatc cccattaaaa atcaaggaat taggggtcgg gggagggttt aggagtgatc   2820

cagaatgacc tcccagaatt actgtgcgta caactttatt tttcagagtt ttcattggaa   2880

tggtaagagt tttatgaaag acagttttaa aacttattct gagttaaata ttaatacttt   2940

aaaaaattat tgtactagac ttattgcagc cttttgaaag tagcagagtt tcatcatacc   3000

acatatataa cagagcataa attttctata atcaggcacc ttttgctgct tttgagtaag   3060

actgttttcc tgtttaagtg ttaagcatcg ccagacataa aaatctattc tctcctctcg   3120

attgtagcat agcctgacag ctctagatac agcatttcta tgatgaaaaa tgagtatcca   3180

tcaggaaatc tagaagacta gccgtgtttt ctcagactcc acctttgttt gcactctgtt   3240

gcctgtgagg agctttctgg catgtgatta tttacttcaa aactagagtt ccaagcacct   3300

acattaatta ttttatattg tgtgcagaat agtatatctt ttaatgtcag atatgataca   3360

ctgcacatat tgcttttgca ctcttaaaat ttttgtacta aataatagaa aatatttata   3420

ttctttgagt gtgagctttg aatagatggc attatcactt tattgttttt ttaacaaaaa   3480

ctttttctca attattctat tgcaatgtta ttctgagcaa gtcctatgcc aaatatcttg   3540

tataatgttt gtatggaaga ttaaatttta ctcttgtgtg gtaagactat ttcagttact   3600

gattttatag ttggaatttg atattccagc acaaagtcca cagtgtattc agaaatccaa   3660

gttggtgtca tacatttcat tttgatgtga acttttcttt gctttccttt gttctaagac   3720

tccattttgc aataaacgtt ttgacagt                                      3748


<210>  8758
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  8758

Met Leu Leu Val Ser Leu Ser Ile His Thr Tyr Val Gln Ile His Glu 
1               5                   10                  15      


His Ser Leu Ser Val Leu Arg His Arg Glu Val Leu Pro Asp Leu Ser 
            20                  25                  30          


Gln Cys Thr Gln Glu Glu Lys Leu Gly Val Glu Gln Lys Gly Gly Leu 
        35                  40                  45              


Gly Thr Pro Val Phe Pro Ala Cys Pro Gly Val Gln Trp Ser Ala Thr 
    50                  55                  60                  


<210>  8759
<211>  3763
<212>  DNA
<213>  Homosapiens

<400>  8759
tgctgatctt cagcgtggga ataataacag tacctacttg aaaggatcat tgtgcggatt     60

aaaagaaata atatatgtaa agcactttaa cacagcacca ggcccacgga aagtggctaa    120

tgttagctac tatgaatggt gccagtgaag acactgaaaa ataagtgatt tcagtaacct    180

tctggaaagc tatcagtttc aaataatatt ttctctgtag tatgagatga aattaaaagt    240

ggatagcttt caggaaagat aaagagaaca tgcttagaat gtaagctaaa cagatttttt    300

ctgttgctct ttgaaaacta tgagccctgg ccagcttaac ctggtctgag gtgagactaa    360

acacaaaaac agtagataaa tctctcccta aaagatggat tcccccacat acccatgcta    420

ctagtttctc tgtctattca cacatatgta caaatacatg aacacagcct gtctgtgctc    480

agacatagag aagtactacc tgacttgagt caatgcaccc aagaagaaaa gcttggagta    540

gagcagaagg gagggcttgg gactcctgtc tttccagcat gccctggggt gcagtggtca    600

gccacctgaa gagagagcca atagcatggg gtttacaagg caaagatagt cattcattca    660

acacatattc atagagctcc ttctctgtgc cagacactgt tctggaagat agctagatga    720

aaatctttgc actcacagag cttacatgcc agtgagtgaa gatcgatgat aaataaagca    780

aatgcatcat atgttcacat ttgataagta tatgccaaaa aatgaagccg ggaaggagga    840

caaggcccat gggtgggtgt tgaggttttt aaagtgtggt caggaaaggc cccactgata    900

aggtaacatt tgagcaagtc tgaaaaaggc aaggggatct ttggggctaa cttcgggatc    960

cctgcacttt atgtaagaat gtaaacctgg agtctcattt aagaatgatc agcaatacgt   1020

ttagaacata tgaactgaat gaaatggaca ttttttctta atttatgtat aaatccatat   1080

gattatacat aaagttctga tgcattaata aaagcagcca aatagggcca aagagaaaaa   1140

taacaggact ctgtactgga cctaactttc tcattactct accaccaaga acctaaaagg   1200

aattagaata cagcagaatt ggcctcagtg aagagcttaa aattgttctc ctcgtagaac   1260

tggactattg atcattacca cgtgacgttg gctctattac tttctgttcc caatgtcctt   1320

ctagtggttt gaaaatgtta aaacatccct aaaatctaaa tcatataatc agaattctat   1380

agtgtcccac tctatctgta aagatcattt ggaagacttt agactctatt aattttaaaa   1440

ggaatattta ttagccatat gcagaatttc taatgatgat attgtacagc ttctaattca   1500

cttttcagat cagtgtttga aatggcaatt atcagtgttg gatttagttc caactacttg   1560

atttacaaaa atgtacattt agaggttaaa agaaacagtg agaaatgtaa acattcaaaa   1620

tgataattga atctctcagt tgtgggaata attatcagag acatgcaact gaaaatgtct   1680

cacctttcat ctttttttct taattcataa agttatcttg tagaatttga tgagaccctc   1740

cctagtcatt ctcaactggg gcggtgctgt caccgaatgg tgtttgagag tgttggggct   1800

agggcacatt tttggttgtc acagcaactg gggtggcatt tgctgcccag tgccaggaat   1860

agtaacatta tgaatgccag ggacagtgtg ctcagtaaag tcttccatcc aaaaggggca   1920

gggcacggtg gctcacgcct gtaatcccag cactttggga ggccaaggtg ggcggatcac   1980

ctgatgtcag gggttcgaga ccagcctggc caacatggtg aaaccctgtt gctactaaaa   2040

atacaaaaat tggctgggtg tggtgtcaca tgccagtaac cccagctact agggaggctg   2100

aggcaggaga atcacttgaa cccgggaggc agaggttgca gtgagctgag attgcaccac   2160

tacactccag cctggatgac agagtgagac ttcatctcaa aaaaaaaaaa aaacaaaaaa   2220

aaacaacccg gtagcattgt cccttcccca ctgacaaact tatcaaatcc agaagcttta   2280

gagtttcgtc tctaattatt tttctcctga acaaaattac ccaagtcaaa acaaaatgta   2340

tttttagaat tacggcagca tacgacctga attttgtgag tttcgtggct ttatcttaaa   2400

tcaccatttc cctaaaaatg gtttctttct ccttagaaat gctggtggca acttgatgaa   2460

acagccaaat gcaccagggc aggtcacttt cccattacac tgattccaca attaaaaaaa   2520

aaaaagaaaa aaaactcatt gagatagcta cagttctata ggttaattta aagcctcctt   2580

tttctactca tttttgaaag caaaattaca ttttactatt ttacataacc agtgaaaaga   2640

cgttgaaagc ctacagctca ctgtttttgg tgctctggaa atgttgaggg tgggttttta   2700

accagtgatt tttaacgtgc agtgaatttg ttagactttt aaacaccagc taaggtagtc   2760

aaacttgatc cccattaaaa atcaaggaat taggggtcgg gggagggttt aggagtgatc   2820

cagaatgacc tcccagaatt actgtgcgta caactttatt tttcagagtt ttcattggaa   2880

tggtaagagt tttatgaaag acagttttaa aacttattct gagttaaata ttaatacttt   2940

aaaaaattat tgtactagac ttattgcagc cttttgaaag tagcagagtt tcatcatacc   3000

acatatataa cagagcataa attttctata atcaggcacc ttttgctgct tttgagtaag   3060

actgttttcc tgtttaagtg ttaagcatcg ccagacataa aaatctattc tctcctctcg   3120

attgtagcat agcctgacag ctctagatac agcatttcta tgatgaaaaa tgagtatcca   3180

tcaggaaatc tagaagacta gccgtgtttt ctcagactcc acctttgttt gcactctgtt   3240

gcctgtgagg agctttctgg catgtgatta tttacttcaa aactagagtt ccaagcacct   3300

acattaatta ttttatattg tgtgcagaat agtatatctt ttaatgtcag atatgataca   3360

ctgcacatat tgcttttgca ctcttaaaat ttttgtacta aataatagaa aatatttata   3420

ttctttgagt gtgagctttg aatagatggc attatcactt tattgttttt ttaacaaaaa   3480

ctttttctca attattctat tgcaatgtta ttctgagcaa gtcctatgcc aaatatcttg   3540

tataatgttt gtatggaaga ttaaatttta ctcttgtgtg gtaagactat ttcagttact   3600

gattttatag ttggaatttg atattccagc acaaagtcca cagtgtattc agaaatccaa   3660

gttggtgtca tacatttcat tttgatgtga acttttcttt gctttccttt gttctaagac   3720

tccattttgc aataaacgtt ttgacagtaa atccctttgt tac                     3763


<210>  8760
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  8760

Met Leu Leu Val Ser Leu Ser Ile His Thr Tyr Val Gln Ile His Glu 
1               5                   10                  15      


His Ser Leu Ser Val Leu Arg His Arg Glu Val Leu Pro Asp Leu Ser 
            20                  25                  30          


Gln Cys Thr Gln Glu Glu Lys Leu Gly Val Glu Gln Lys Gly Gly Leu 
        35                  40                  45              


Gly Thr Pro Val Phe Pro Ala Cys Pro Gly Val Gln Trp Ser Ala Thr 
    50                  55                  60                  


<210>  8761
<211>  692
<212>  DNA
<213>  Homosapiens

<400>  8761
tgaaatggac attttttctt aatttatgta taaatccata tgattataca taaagttctg     60

atgcattaat aaaagcagcc aaatagggcc aaagagaaaa ataacaggac tctgtactgg    120

acctaacttt atcattaatt aggtaatatt ttcctcattt ctttactgct gccattttcc    180

tcaccagtat tccagagatg gtcatagctc attactctac caccaagaac ctaaaaggaa    240

ttagaataca gcagaattgg cctcagtgaa gagcttaaaa ttgttctcct cgtagaactg    300

gactattgat cattaccacg tgacgttggc tctattactt tctgttccca atgtccttct    360

agtggtttga aaatgttaaa acatccctaa aatctaaatc atataatcag aattctatag    420

tgtcccactc tatctgtaaa gatcatttgg aagactttag actctattaa ttttaaaagg    480

aatatttatt agccatatgc agaatttcta atgatgatat tgtacagctt ctaattcact    540

tttcagatca gtgtttgaaa tggcaattat cagtgttgga tttagttcca actacttgat    600

ttacaaaaat gtacatttag aggttaaaag aaacatgagc tgagattgca ccactacact    660

ccagcctgga tgacagagtg agacttcatc tc                                  692


<210>  8762
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  8762

Lys Glu Tyr Leu Leu Ala Ile Cys Arg Ile Ser Asn Asp Asp Ile Val 
1               5                   10                  15      


Gln Leu Leu Ile His Phe Ser Asp Gln Cys Leu Lys Trp Gln Leu Ser 
            20                  25                  30          


Val Leu Asp Leu Val Pro Thr Thr 
        35                  40  


<210>  8763
<211>  498
<212>  DNA
<213>  Homosapiens

<400>  8763
atggtcaacc ccaccgtgtt cttccacatc tctgtcgacg gtgagtcctt gggccgcatc     60

tcttttgagc tgtttgcaga caagtttcca aagacagcag aaaacttttg tgctctgaat    120

actggagaga aaggatttgg ttacaagggt tgctgctttc acagaattat tccagggttt    180

atgtgtcatg gtggtgactt cacacaccat aatggcactg gtggcaagtc aatctacggg    240

gagaaagttg atgatgacaa cttcatcctg aagcatacag gtcctggcat attgtccatg    300

gcaaatgctg gacccaacac aaatggttcc cagtttttca tctgcactgc caagtctgag    360

tggttggata gcaagcatgt ggtcattggc aaggtgaaag aaggcatgaa tattgtggag    420

gccatggagc actttgggtc caggaatggc aagaccagca agaaggtcac cattcctgac    480

tttggacaac tcgaataa                                                  498


<210>  8764
<211>  165
<212>  PRT
<213>  Homosapiens

<400>  8764

Met Val Asn Pro Thr Val Phe Phe His Ile Ser Val Asp Gly Glu Ser 
1               5                   10                  15      


Leu Gly Arg Ile Ser Phe Glu Leu Phe Ala Asp Lys Phe Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Cys Ala Leu Asn Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Cys Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys His Gly 
    50                  55                  60                  


Gly Asp Phe Thr His His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Val Asp Asp Asp Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Ser Glu Trp Leu Asp Ser Lys His Val Val 
        115                 120                 125             


Ile Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu His 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Val Thr Ile Pro Asp 
145                 150                 155                 160 


Phe Gly Gln Leu Glu 
                165 


<210>  8765
<211>  518
<212>  DNA
<213>  Homosapiens

<400>  8765
gagctgttcc tattcggcca tcttggctcc tccgctctat ttgcagttct taaagggccc     60

caggatcctc tattaaatgt gtggtccatg aaccagcagc ttcagcatga cctgagagct    120

cataacctcg tctctacaaa aaatacaaaa aaagttagcc aggcatggtg gtacacgcct    180

atggtctcag caacttggga ggctgaggcc aagtctcgcc acatggcatc atttcctcct    240

cacctgcaga atcgctgtga cttatggctc ctctgattgc acctgctttc accagcagcc    300

ctggaagaga gctcttctgt gtggataaga gttgagagat cttggtttca ttacttgttt    360

aaattggacc ctctcaaatg aatgtaagca cataatgggg ggactacact atgagattaa    420

aaggaatcca gctgttacca gaaatgggtg cctgccaggt ttatccacca aattctttcc    480

acttcatgtc attaaaataa aatttgagtt ttaaaatg                            518


<210>  8766
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  8766

Met Asn Gln Gln Leu Gln His Asp Leu Arg Ala His Asn Leu Val Ser 
1               5                   10                  15      


Thr Lys Asn Thr Lys Lys Val Ser Gln Ala Trp Trp Tyr Thr Pro Met 
            20                  25                  30          


Val Ser Ala Thr Trp Glu Ala Glu Ala Lys Ser Arg His Met Ala Ser 
        35                  40                  45              


Phe Pro Pro His Leu Gln Asn Arg Cys Asp Leu Trp Leu Leu 
    50                  55                  60          


<210>  8767
<211>  1877
<212>  DNA
<213>  Homosapiens

<400>  8767
ctctggtctc ctgactctgg cagggggaac atttgcactg ttcttgttcc ttaccccagg     60

agctggccta ttgcacaacc tcaggaaaca gcccctatgc aatcctggcc cacagagcgg    120

acatgttctg gtttttattc agcagctttt ttatgaagtg tgttttcctt tcccatcatg    180

tcatctggaa gcaattcctc ccaacagctg gatttgcttt cacaattggt aaacaccgcg    240

aatggaaggc cggggacgat gcggagctcc ccggaggagc cttgtcccca cccgcttggc    300

tcgcgttctg aagcttatcg cgggtgcctg cacaagcctc atcaaaatcg agggcgtcct    360

ccagcaggcg acccacattg cattccccgc ttaagagggt caacgtgttc ttcgggggag    420

aaattttctg aatgctttgc agataaaatt gatcagatgc aggccagatt gccagctgcc    480

ggggccgcgt gcgcctgtgg aggccccacc agcgcggggc accagcgcct cggggtccgg    540

gggaggcctc tctctgcacc gccgccacca aagccagtaa gagagggcaa aaccccaaag    600

agcactgact gggccgtcaa ggaagatgaa tgtctcccca aaagtgctcc tcggggacaa    660

gtttccacgc agatgcaacc gggaacgccg gccaggctcc ggaaggcgag gccccagagc    720

gcagcggcct ccaagcgcgg gctcagcctg tcgcctccgc agccagggcc caggaggccg    780

ctcttccggg gtcaccaaca cggctcgttc tgagcctaga ggcccagggc acagtgtgag    840

ccggaatacg gtgtagggga cacagctcag gccccaggca ctccctcctg tcgcagaaga    900

aatgctgttc tttgatcaat gtttctaatg tggggaaacc agccgagcac gtggctgaac    960

tctcggaggg agcacggggt gctggtgagc ccccgctctg atgcacagag acgctgctgg   1020

ccaggctggg gtgggttgca aaggcttcct tccatgcacc accaaccctg tgggcagcca   1080

gggcctagct ctcatgaagg ggccttccca gggcaaagtg ggcctctgac tgcaacgttc   1140

tctgggcaga gataggcatc cttcccactg cacaaacaaa aggagaccgt caaggggaga   1200

ggctcaccag aggaccctgg tgagggcgac gcccaactcc tcagcacaag gctgtgcttc   1260

ttccatggag cccgtttgcc tgggcccagc gcgtgcggag tgcgttcctt ctcgctccct   1320

ctgtcctgtg ggccctcctc tctctccctc cagcctggtg gaagctttat tctcgtcggg   1380

ggccagagga cagaaactac atcatacatt ttcccgtgcg tcatgttatc ttgcctggaa   1440

ttttgaaaat ctgtgagttt ctggtttttc catggcaagg ctcattcctc cagaccttag   1500

tcactctgct ctggctgcct ggactgctag agaggggcct cagggcgcac ctggagaaat   1560

tcactggggc ccaggtcaga gggatgggtg ggtgagagca accccttcct taatagttca   1620

aaatggccct ctggcttaaa gagaccgaag ccacgtaaca accaaatgca atgtgtgggc   1680

cgtgtttgga tcctgattca aacaaaccaa ctggaagagg agatttgggg ataatcagga   1740

agatttgaat tgggactgcg tagcagaaaa tagcaaagaa ttattgttaa ttttgatatg   1800

tgcgataatg gtgtggtagt tatagaagaa aacatgctta tcttttaaat ggtgtatatt   1860

aaagtattta agggtga                                                  1877


<210>  8768
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  8768

Met Ser Ser Gly Ser Asn Ser Ser Gln Gln Leu Asp Leu Leu Ser Gln 
1               5                   10                  15      


Leu Val Asn Thr Ala Asn Gly Arg Pro Gly Thr Met Arg Ser Ser Pro 
            20                  25                  30          


Glu Glu Pro Cys Pro His Pro Leu Gly Ser Arg Ser Glu Ala Tyr Arg 
        35                  40                  45              


Gly Cys Leu His Lys Pro His Gln Asn Arg Gly Arg Pro Pro Ala Gly 
    50                  55                  60                  


Asp Pro His Cys Ile Pro Arg Leu Arg Gly Ser Thr Cys Ser Ser Gly 
65                  70                  75                  80  


Glu Lys Phe Ser Glu Cys Phe Ala Asp Lys Ile Asp Gln Met Gln Ala 
                85                  90                  95      


Arg Leu Pro Ala Ala Gly Ala Ala Cys Ala Cys Gly Gly Pro Thr Ser 
            100                 105                 110         


Ala Gly His Gln Arg Leu Gly Val Arg Gly Arg Pro Leu Ser Ala Pro 
        115                 120                 125             


Pro Pro Pro Lys Pro Val Arg Glu Gly Lys Thr Pro Lys Ser Thr Asp 
    130                 135                 140                 


Trp Ala Val Lys Glu Asp Glu Cys Leu Pro Lys Ser Ala Pro Arg Gly 
145                 150                 155                 160 


Gln Val Ser Thr Gln Met Gln Pro Gly Thr Pro Ala Arg Leu Arg Lys 
                165                 170                 175     


Ala Arg Pro Gln Ser Ala Ala Ala Ser Lys Arg Gly Leu Ser Leu Ser 
            180                 185                 190         


Pro Pro Gln Pro Gly Pro Arg Arg Pro Leu Phe Arg Gly His Gln His 
        195                 200                 205             


Gly Ser Phe 
    210     


<210>  8769
<211>  531
<212>  DNA
<213>  Homosapiens

<400>  8769
atgtccagag cccttgatgt cctgccaatg aaggaggagg atgtcctcaa gttccttgca     60

gcaggaaccc acttaggtga cactaatttt gacttccaaa tggaacagta catctataaa    120

atgaaaagtg atggcatcta catcctaaat cagaagaaga cctgggagaa gttgctgctg    180

gcagcttgtg ccattgttgc cattgaaaac cctgctgatg tcagtgtcat atcctccagg    240

aaaactggcc agaaagccac gccgttgttt gctgctgtca ctggagccac tcttgttgct    300

ggctgcttta ctcctagaac attctctaac cagatctcag cagccttccg ggagccacag    360

cttctgcctc tcctcctcct ctcctctgta cgtcagccag cacctcagct tcgtcctcac    420

aggggactct cacggctgga aagacttggt tctatggaaa cagaacgcac tgattcactg    480

atgagctcca tggagcttca aacacaggcc acatacacgg gcaccttatg a             531


<210>  8770
<211>  176
<212>  PRT
<213>  Homosapiens

<400>  8770

Met Ser Arg Ala Leu Asp Val Leu Pro Met Lys Glu Glu Asp Val Leu 
1               5                   10                  15      


Lys Phe Leu Ala Ala Gly Thr His Leu Gly Asp Thr Asn Phe Asp Phe 
            20                  25                  30          


Gln Met Glu Gln Tyr Ile Tyr Lys Met Lys Ser Asp Gly Ile Tyr Ile 
        35                  40                  45              


Leu Asn Gln Lys Lys Thr Trp Glu Lys Leu Leu Leu Ala Ala Cys Ala 
    50                  55                  60                  


Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg 
65                  70                  75                  80  


Lys Thr Gly Gln Lys Ala Thr Pro Leu Phe Ala Ala Val Thr Gly Ala 
                85                  90                  95      


Thr Leu Val Ala Gly Cys Phe Thr Pro Arg Thr Phe Ser Asn Gln Ile 
            100                 105                 110         


Ser Ala Ala Phe Arg Glu Pro Gln Leu Leu Pro Leu Leu Leu Leu Ser 
        115                 120                 125             


Ser Val Arg Gln Pro Ala Pro Gln Leu Arg Pro His Arg Gly Leu Ser 
    130                 135                 140                 


Arg Leu Glu Arg Leu Gly Ser Met Glu Thr Glu Arg Thr Asp Ser Leu 
145                 150                 155                 160 


Met Ser Ser Met Glu Leu Gln Thr Gln Ala Thr Tyr Thr Gly Thr Leu 
                165                 170                 175     


<210>  8771
<211>  4348
<212>  DNA
<213>  Homosapiens

<400>  8771
gcgcaggtgc cgctcggcgc ccggcccgcc cgttccgccg ctgtcgccgc cgtcgtgcgt     60

gccgctcggc ggaggggacg ggcctgcgtt ctctcctcct tcctccccgc ctccagctgc    120

cggcaggacc tttctctcgc tgccgctggg accccgtgtc atcgcccagg ccgagcacga    180

tgccccctaa aaagggaggt gatggaatta aaccaccccc aatcattgga agatttggaa    240

cctcactgaa aattggtatt gttggattgc caaatgttgg gaaatctact ttcttcaatg    300

tgttaaccaa tagtcaggct tcagcagaaa acttcccgtt ctgcactatt gatcctaatg    360

agagcagagt acctgtgcca gatgaaaggt ttgactttct ttgtcaatac cacaaaccag    420

caagcaaaat tcctgccttt ctaaatgtgg tggatattgc tggccttgtg aaaggagctc    480

acaatgggca gggcctgggg aatgcttttt tatctcatat tagtgcctgt gatggcatct    540

ttcatctaac acgtgctttt gaagatgatg atatcacgca cgttgaagga agtgtagatc    600

ctattcgaga tatagaaata atacatgaag agcttcagct taaagatgag gaaatgattg    660

ggcccattat agataaacta gaaaaggtgg ctgtgagagg aggagataaa aaactaaaac    720

ctgaatatga tataatgtgc aaagtaaaat cctgggttat agatcaaaag aaacctgttc    780

gcttctatca tgattggaat gacaaagaga ttgaagtgtt gaataaacac ttatttttga    840

cttcaaaacc aatggtctac ttggttaatc tttctgaaaa agactacatt agaaagaaaa    900

acaaatggtt gataaaaatt aaagagtggg tggacaagta tgacccaggt gctttggtca    960

ttccttttag tggggccttg gaactcaagt tgcaagaatt gagtgctgag gagagacaga   1020

agtatctgga agcgaacatg acacaaagtg ctttgccaaa gatcattaag gctgggtttg   1080

cagcactcca actagaatac tttttcactg caggcccaga tgaagtgcgt gcatggacca   1140

tcaggaaagg gactaaggct cctcaggctg caggaaagat tcacacagat tttgaaaagg   1200

gattcattat ggctgaagta atgaaatacg aagattttaa agaggaaggt tctgaaaatg   1260

cagtcaaggc tgctggaaag tacagacaac aaggcagaaa ttatattgtt gaagatggag   1320

atattatctt cttcaaattt aacacacctc aacaaccgaa gaagaaataa aatttagtta   1380

ttgctcagat aaacatacaa cttccaaaag gcatctgatt tttaaaaaat taaaatttct   1440

gaaaaccaat gcgacaaata aagttgggga gatgggaatc tttgacaaac aaattatttt   1500

tatttgtttt aaaattaaaa tactgtgtac cccccccccc ccatgaaatg caggttcact   1560

aaatgtgaac agctttgctt ttcacgtgat taagacccta ctccaaattg tagaagcttt   1620

tcaggaacca tattactctc atgatacttc attaatctcc atcatgtatg ccaagcctga   1680

cacatttgac agtgaggaca atgtggcttg ctcctttttg aatctacaga taatgcatgt   1740

tttacagtac tccagatgtc tacactcaat aaaacatttg acaaaaccag ccttggtgtg   1800

tttggggatg tctgtattga ctgactgtgg tgtgctgaat gcgatacggc acctggtggt   1860

tgctgattac agaattttaa ggcgtgtgta tgacacagta actggcagtg tggggcagct   1920

gcaattgtat cttaaaagtg agtctttcat gggaatcaga agaatagtat accagggatt   1980

tgtctcaaaa aagttaatta atttatagat caacatttat tgaaagatga tagcaatgat   2040

attatgaggg atatgagata ggtgactgac cacaaagaag aaaattctgt ctcaaaaatt   2100

aaagaatttt gtttgttatt gttgttctga ccatattgaa aagaggttca cttttaatct   2160

ttcctttgaa attattaaat tgtaaaaact gacccattga tgtctggtgg gttatgtttt   2220

gcttcaattc agcaatgtgt ataaaagttc ctacactgat tttgaaatac taagatcaga   2280

ctttgaaaat tttaaaaatt ctttcattct tacttttcag atatttgaga gcagtcgaag   2340

tggtagtatg ggtaagttaa gcacttctta acattgtagc agaaaattcc aaaagaaaga   2400

ctagaacaaa ttggtaattt ggagaccctt tgccacttag ccttctcttg tgatgatggc   2460

ctgaaagctc tctcggccct gagcctccct ttctctccca tgtttccatt cctgtgagac   2520

ctcccttcct tgtccttgtc ctctgccctt ttgtgctctt ctgtgatcac aggaccattt   2580

ccatggaatg cagattcata cccagccagc ctttgcctct actgtatcgc tttgggactt   2640

taaagatgca gaagtattag aacacacaca aacttaaaat ggaaagttac caaatgtagc   2700

actagaggca agaaaagggg tgatttttta aagatttggc tatacttaag atatttaaag   2760

aggatgaggt tgagtcgtga gtataattta gaagctctcc agtgagtatt tttttagtat   2820

caaatagtga tcttcttttg ctaacataaa aatgagtaaa ctacagcaga gaaataagaa   2880

taaaactaat gaagggtttt ttaaaagaac taaataaaac aaataaaact aggctacagg   2940

tatagctgac caagtttgct gtgaaaaatc cttgttatat ctatttctgt attggagtaa   3000

tgtgtagatt agtggattgt tagggatttc agcagtataa gaaagaatca aatatcttgc   3060

ttttgggtct tctccaaagt aaattgcatg gacttcttaa agaagtttga aatcagtaaa   3120

aagacattag gatcatgcaa ttttactttg tctagcttct aatgtggtaa attgcacatt   3180

gtgcaacaga accattaata aaagaaagga gttagttttg aggtaactgc attcattagg   3240

ggctgaaaat aaatgttaaa aatgtttaat ttggttagaa gttctacaac attgtatgta   3300

catatacaaa atttcatttt ctctgaaagt cgagaattcc aagaactgtt acatataatc   3360

atatatatgc ctatatctaa acgttttccc tcctttaata ttgataaagt taatatattt   3420

taggatgtta tgtaaatatt tttgcatgta tctgtagctc catcttaatc aaatttatgg   3480

ttaaaagaga tttgaggcca ggcgtggagg ctcacaccta taatcccaac actttgggag   3540

gccgaggtgg gaggatcact tgagcacagg agtttgagac cagcctgtgc aacatcatga   3600

aacatcatct ctacataaaa aaatacatat atacaaaaat tagctgggca tcatggcaca   3660

cacctgtagt cccagctact taggaggctg agatgggagg attgatcgat cgcttgagcc   3720

tgggaggtgg aggctactgt gagccatgat catgccactg cactccagcc tgggcaacag   3780

agtgagaccc tgtctccaaa gagaaagaga aacttgagaa ggcttgtgcc caaagcttga   3840

agaaagattg taatagcatt tagttgtgtt ttatcatgtt atcttcataa catgcatttt   3900

gcatatggct cagagcagag ccggatctcc caaggaagca caaatagttt ttgtcgctaa   3960

cttagttatg agtgaagcct ctgttcactt ataacttgcc agtttcattg gtggaataag   4020

tccccttact catgattcat caatattcct atattaaaat tccagtttga tgtttgtctc   4080

tagttgtctg tgtataatat ttccaaagct cctttgtaaa ccccgtctcc tttcattcag   4140

agagtcagag acggtatctc ctcctcctgc ctcttctatt gttctgatta gtctacttaa   4200

attcacttga tgctcttttt attttacaag agacttgaga aatgtcggtt gttcctaatg   4260

gcaaactact ttagctggga aaattcattt caacttattt taagcttgta aaatacactg   4320

tggtgataaa ataaaagagc tgggtttg                                      4348


<210>  8772
<211>  396
<212>  PRT
<213>  Homosapiens

<400>  8772

Met Pro Pro Lys Lys Gly Gly Asp Gly Ile Lys Pro Pro Pro Ile Ile 
1               5                   10                  15      


Gly Arg Phe Gly Thr Ser Leu Lys Ile Gly Ile Val Gly Leu Pro Asn 
            20                  25                  30          


Val Gly Lys Ser Thr Phe Phe Asn Val Leu Thr Asn Ser Gln Ala Ser 
        35                  40                  45              


Ala Glu Asn Phe Pro Phe Cys Thr Ile Asp Pro Asn Glu Ser Arg Val 
    50                  55                  60                  


Pro Val Pro Asp Glu Arg Phe Asp Phe Leu Cys Gln Tyr His Lys Pro 
65                  70                  75                  80  


Ala Ser Lys Ile Pro Ala Phe Leu Asn Val Val Asp Ile Ala Gly Leu 
                85                  90                  95      


Val Lys Gly Ala His Asn Gly Gln Gly Leu Gly Asn Ala Phe Leu Ser 
            100                 105                 110         


His Ile Ser Ala Cys Asp Gly Ile Phe His Leu Thr Arg Ala Phe Glu 
        115                 120                 125             


Asp Asp Asp Ile Thr His Val Glu Gly Ser Val Asp Pro Ile Arg Asp 
    130                 135                 140                 


Ile Glu Ile Ile His Glu Glu Leu Gln Leu Lys Asp Glu Glu Met Ile 
145                 150                 155                 160 


Gly Pro Ile Ile Asp Lys Leu Glu Lys Val Ala Val Arg Gly Gly Asp 
                165                 170                 175     


Lys Lys Leu Lys Pro Glu Tyr Asp Ile Met Cys Lys Val Lys Ser Trp 
            180                 185                 190         


Val Ile Asp Gln Lys Lys Pro Val Arg Phe Tyr His Asp Trp Asn Asp 
        195                 200                 205             


Lys Glu Ile Glu Val Leu Asn Lys His Leu Phe Leu Thr Ser Lys Pro 
    210                 215                 220                 


Met Val Tyr Leu Val Asn Leu Ser Glu Lys Asp Tyr Ile Arg Lys Lys 
225                 230                 235                 240 


Asn Lys Trp Leu Ile Lys Ile Lys Glu Trp Val Asp Lys Tyr Asp Pro 
                245                 250                 255     


Gly Ala Leu Val Ile Pro Phe Ser Gly Ala Leu Glu Leu Lys Leu Gln 
            260                 265                 270         


Glu Leu Ser Ala Glu Glu Arg Gln Lys Tyr Leu Glu Ala Asn Met Thr 
        275                 280                 285             


Gln Ser Ala Leu Pro Lys Ile Ile Lys Ala Gly Phe Ala Ala Leu Gln 
    290                 295                 300                 


Leu Glu Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Arg Ala Trp Thr 
305                 310                 315                 320 


Ile Arg Lys Gly Thr Lys Ala Pro Gln Ala Ala Gly Lys Ile His Thr 
                325                 330                 335     


Asp Phe Glu Lys Gly Phe Ile Met Ala Glu Val Met Lys Tyr Glu Asp 
            340                 345                 350         


Phe Lys Glu Glu Gly Ser Glu Asn Ala Val Lys Ala Ala Gly Lys Tyr 
        355                 360                 365             


Arg Gln Gln Gly Arg Asn Tyr Ile Val Glu Asp Gly Asp Ile Ile Phe 
    370                 375                 380                 


Phe Lys Phe Asn Thr Pro Gln Gln Pro Lys Lys Lys 
385                 390                 395     


<210>  8773
<211>  1757
<212>  DNA
<213>  Homosapiens

<400>  8773
gttccgccgc tgtcgccgcc gtcgtgcgtg ccgctcggcg gaggggacgg gcctgcgttc     60

tctcctcctt cctccccgcc tccagctgcc ggcaggacct ttctctcgct gccgctggga    120

ccccgtgtca tcgcccaggc cgagcacgga aatctacttt cttcaatgtg ttaaccaata    180

gtcaggcttc agcagaaaac ttcccgttct gcactattga tcctaatgag agcagagtac    240

ctgtgccaga tgaaaggttt gactttcttt gtcaatacca caaaccagca agcaaaattc    300

ctgcctttct aaatgtggtg gatattgctg gccttgtgaa aggagctcac aatgggcagg    360

gcctggggaa tgctttttta tctcatatta gtgcctgtga tggcatcttt catctaacac    420

gtgcttttga agatgatgat atcacgcacg ttgaaggaag tgtagatcct attcgagata    480

tagaaataat acatgaagag cttcagctta aagatgagga aatgattggg cccattatag    540

ataaactaga aaaggtggct gtgagaggag gagataaaaa actaaaacct gaatatgata    600

taatgtgcaa agtaaaatcc tgggttatag atcaaaagaa acctgttcgc ttctatcatg    660

attggaatga caaagagatt gaagtgttga ataaacactt atttttgact tcaaaaccaa    720

tggtctactt ggttaatctt tctgaaaaag actacattag aaagaaaaac aaatggttga    780

taaaaattaa agagtgggtg gacaagtatg acccaggtgc tttggtcatt ccttttagtg    840

gggccttgga actcaagttg caagaattga gtgctgagga gagacagaag tatctggaag    900

cgaacatgac acaaagtgct ttgccaaaga tcattaaggc tgggtttgca gcactccaac    960

tagaatactt tttcactgca ggcccagatg aagtgcgtgc atggaccatc aggaaaggga   1020

ctaaggctcc tcaggctgca ggaaagattc acacagattt tgaaaaggga ttcattatgg   1080

ctgaagtaat gaaatacgaa gattttaaag aggaaggttc tgaaaatgca gtcaaggctg   1140

ctggaaagta cagacaacaa ggcagaaatt atattgttga agatggagat attatcttct   1200

tcaaatttaa cacacctcaa caaccgaaga agaaataaaa tttagttatt gctcagataa   1260

acatacaact tccaaaaggc atctgatttt taaaaaatta aaatttctga aaaccaatgc   1320

gacaaataaa gttggggaga tgggaatctt tgacaaacaa attattttta tttgttttaa   1380

aattaaaata ctgtgtaccc cccccccccc atgaaatgca ggttcactaa atgtgaacag   1440

ctttgctttt cacgtgatta agaccctact ccaaattgta gaagcttttc aggaaccata   1500

ttactctcat gatacttcat taatctccat catgtatgcc aagcctgaca catttgacag   1560

tgaggacaat gtggcttgct cctttttgaa tctacagata atgcatgttt tacagtactc   1620

cagatgtcta cactcaataa aacatttgac aaaaccagcc ttggtgtgtt tggggatgtc   1680

tgtattgact gactgtggtg tgctgaatgc gatacggcac ctggtggttg ctgattacag   1740

aattttaagg cgtgtgt                                                  1757


<210>  8774
<211>  238
<212>  PRT
<213>  Homosapiens

<400>  8774

Met Ile Gly Pro Ile Ile Asp Lys Leu Glu Lys Val Ala Val Arg Gly 
1               5                   10                  15      


Gly Asp Lys Lys Leu Lys Pro Glu Tyr Asp Ile Met Cys Lys Val Lys 
            20                  25                  30          


Ser Trp Val Ile Asp Gln Lys Lys Pro Val Arg Phe Tyr His Asp Trp 
        35                  40                  45              


Asn Asp Lys Glu Ile Glu Val Leu Asn Lys His Leu Phe Leu Thr Ser 
    50                  55                  60                  


Lys Pro Met Val Tyr Leu Val Asn Leu Ser Glu Lys Asp Tyr Ile Arg 
65                  70                  75                  80  


Lys Lys Asn Lys Trp Leu Ile Lys Ile Lys Glu Trp Val Asp Lys Tyr 
                85                  90                  95      


Asp Pro Gly Ala Leu Val Ile Pro Phe Ser Gly Ala Leu Glu Leu Lys 
            100                 105                 110         


Leu Gln Glu Leu Ser Ala Glu Glu Arg Gln Lys Tyr Leu Glu Ala Asn 
        115                 120                 125             


Met Thr Gln Ser Ala Leu Pro Lys Ile Ile Lys Ala Gly Phe Ala Ala 
    130                 135                 140                 


Leu Gln Leu Glu Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Arg Ala 
145                 150                 155                 160 


Trp Thr Ile Arg Lys Gly Thr Lys Ala Pro Gln Ala Ala Gly Lys Ile 
                165                 170                 175     


His Thr Asp Phe Glu Lys Gly Phe Ile Met Ala Glu Val Met Lys Tyr 
            180                 185                 190         


Glu Asp Phe Lys Glu Glu Gly Ser Glu Asn Ala Val Lys Ala Ala Gly 
        195                 200                 205             


Lys Tyr Arg Gln Gln Gly Arg Asn Tyr Ile Val Glu Asp Gly Asp Ile 
    210                 215                 220                 


Ile Phe Phe Lys Phe Asn Thr Pro Gln Gln Pro Lys Lys Lys 
225                 230                 235             


<210>  8775
<211>  1429
<212>  DNA
<213>  Homosapiens

<400>  8775
gcgcaggtgc cgctcggcgc ccggcccgcc cgttccgccg ctgtcgccgc cgtcgtgcgt     60

gccgctcggc ggaggggacg ggcctgcgtt ctctcctcct tcctccccgc ctccagctgc    120

cggcaggacc tttctctcgc tgccgctggg accccgtgtc atcgcccagg ccgagcacga    180

tgccccctaa aaagggaggt gatggaatta aaccaccccc aatcattgga agatttggaa    240

cctcactgaa aattggtatt gttggattgc caaatgttgg gaaatctact ttcttcaatg    300

tgttaaccaa tagtcaggct tcagcagaaa acttcccgtt ctgcactatt gatcctaatg    360

agagcagagt acctgtgcca gatgaaaggt ttgactttct ttgtcaatac cacaaaccag    420

caagcaaaat tcctgccttt ctaaatgtgg tggatattgc tggccttgtg aaaggagctc    480

acaatgggca gggcctgggg aatgcttttt tatctcatat tagtgcctgt gatggcatct    540

ttcatctaac acgtgctttt gaagatgatg atatcacgca cgttgaagga agtgtagatc    600

ctattcgaga tatagaaata atacatgaag agcttcagct taaagatgag gaaatgattg    660

ggcccattat agataaacta gaaaaggtgg ctgtgagagg aggagataaa aaactaaaac    720

ctgaatatga tataatgtgc aaagtaaaat cctgggttat agatcaaaag aaacctgttc    780

gcttctatca tgattggaat gacaaagaga ttgaagtgtt gaataaacac ttatttttga    840

cttcaaaacc aatggtctac ttggttaatc tttctgaaaa agactacatt agaaagaaaa    900

acaaatggct gctggaaagt acagacaaca aggcagaaat tatattgttg aagatggaga    960

tattatcttc ttcaaattta acacacctca acaaccgaag aagaaataaa atttagttat   1020

tgctcagata aacatacaac ttccaaaagg catctgattt ttaaaaaatt aaaatttctg   1080

aaaaccaatg cgacaaataa agttggggag atgggaatct ttgacaaaca aattattttt   1140

atttgtttta aaattaaaat actgtgtacc cccccccccc catgaaatgc aggttcacta   1200

aatgtgaaca gctttgcttt tcacgtgatt aagaccctac tccaaattgt agaagctttt   1260

caggaaccat attactctca tgatacttca ttaatctcca tcatgtatgc caagcctgac   1320

acatttgaca gtgaggacaa tgtggcttgc tcctttttga atctacagat aatgcatgtt   1380

ttacagtact ccagatgtct acactcaata aaacatttga caaaaccag               1429


<210>  8776
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  8776

Met Pro Pro Lys Lys Gly Gly Asp Gly Ile Lys Pro Pro Pro Ile Ile 
1               5                   10                  15      


Gly Arg Phe Gly Thr Ser Leu Lys Ile Gly Ile Val Gly Leu Pro Asn 
            20                  25                  30          


Val Gly Lys Ser Thr Phe Phe Asn Val Leu Thr Asn Ser Gln Ala Ser 
        35                  40                  45              


Ala Glu Asn Phe Pro Phe Cys Thr Ile Asp Pro Asn Glu Ser Arg Val 
    50                  55                  60                  


Pro Val Pro Asp Glu Arg Phe Asp Phe Leu Cys Gln Tyr His Lys Pro 
65                  70                  75                  80  


Ala Ser Lys Ile Pro Ala Phe Leu Asn Val Val Asp Ile Ala Gly Leu 
                85                  90                  95      


Val Lys Gly Ala His Asn Gly Gln Gly Leu Gly Asn Ala Phe Leu Ser 
            100                 105                 110         


His Ile Ser Ala Cys Asp Gly Ile Phe His Leu Thr Arg Ala Phe Glu 
        115                 120                 125             


Asp Asp Asp Ile Thr His Val Glu Gly Ser Val Asp Pro Ile Arg Asp 
    130                 135                 140                 


Ile Glu Ile Ile His Glu Glu Leu Gln Leu Lys Asp Glu Glu Met Ile 
145                 150                 155                 160 


Gly Pro Ile Ile Asp Lys Leu Glu Lys Val Ala Val Arg Gly Gly Asp 
                165                 170                 175     


Lys Lys Leu Lys Pro Glu Tyr Asp Ile Met Cys Lys Val Lys Ser Trp 
            180                 185                 190         


Val Ile Asp Gln Lys Lys Pro Val Arg Phe Tyr His Asp Trp Asn Asp 
        195                 200                 205             


Lys Glu Ile Glu Val Leu Asn Lys His Leu Phe Leu Thr Ser Lys Pro 
    210                 215                 220                 


Met Val Tyr Leu Val Asn Leu Ser Glu Lys Asp Tyr Ile Arg Lys Lys 
225                 230                 235                 240 


Asn Lys Trp Leu Leu Glu Ser Thr Asp Asn Lys Ala Glu Ile Ile Leu 
                245                 250                 255     


Leu Lys Met Glu Ile Leu Ser Ser Ser Asn Leu Thr His Leu Asn Asn 
            260                 265                 270         


Arg Arg Arg Asn Lys Ile 
        275             


<210>  8777
<211>  1656
<212>  DNA
<213>  Homosapiens

<400>  8777
gttccgccgc tgtcgccgcc gtcgtgcgtg ccgctcggcg gaggggacgg gcctgcgttc     60

tctcctcctt cctccccgcc tccagctgcc ggcaggacct ttctctcgct gccgctggga    120

ccccgtgtca tcgcccaggc cgagcacgga aatctacttt cttcaatgtg ttaaccaata    180

gtcaggcttc agcagaaaac ttcccgttct gcactattga tcctaatgag agcagagtac    240

ctgtgccaga tgaaaggttt gactttcttt gtcaatacca caaaccagca agcaaaattc    300

ctgcctttct aaatgtggtg gatattgctg gccttgtgaa aggagctcac aatgggcagg    360

gcctggggaa tgctttttta tctcatatta gtgcctgtga tggcatcttt catctaacac    420

gtgcttttga agatgatgat atcacgcacg ttgaaggaag tgtagatcct attcgagata    480

tagaaataat acatgaagag cttcagctta aagatgagga aatgattggg cccattatag    540

ataaactaga aaaggtggct gtgagaggag gagataaaaa actaaaacct gaatatgata    600

taatgtgcaa agtaaaatcc tgggttatag atcaaaagaa acctgttcgc ttctatcatg    660

attggaatga caaagagatt gaagtgttga ataaacactt atttttgact tcaaaaccaa    720

tggtctactt ggttaatctt tctgaaaaag actacattag aaagaaaaac aaatggttga    780

taaaaattaa agagtgggtg gacaagtatg acccaggtgc tttggtcatt ccttttagtg    840

gggccttgga actcaagttg caagaattga gtgctgagga gagacagaag tatctggaag    900

cgaacatgac acaaagtgct ttgccaaaga tcattaaggc tgggtttgca gcactccaac    960

tagaatactt tttcactgca ggcccagatg aagtgcgtgc atggaccatc aggaaaggga   1020

ctaaggctcc tcaggctgca ggaaagattc acacagattt tgaaaaggga ttcattatgg   1080

ctgaagtaat gaaatacgaa gattttaaag aggaaggttc tgaaaatgca gtcaaggctg   1140

ctggaaagta cagacaacaa ggcagaaatt atattgttga agatggagat attatcttct   1200

tcaaatttaa cacacctcaa caaccgaaga agaaataaaa tttagttatt gctcagataa   1260

acatacaact tccaaaaggc atctgatttt taaaaaatta aaatttctga aaaccaatgc   1320

gacaaataaa gttggggaga tgggaatctt tgacaaacaa attattttta tttgttttaa   1380

aattaaaata ctgtgtaccc cccccccccc atgaaatgca ggttcactaa atgtgaacag   1440

ctttgctttt cacgtgatta agaccctact ccaaattgta gaagcttttc aggaaccata   1500

ttactctcat gatacttcat taatctccat catgtatgcc aagcctgaca catttgacag   1560

tgaggacaat gtggcttgct cctttttgaa tctacagata atgcatgttt tacagtactc   1620

cagatgtcta cactcaataa aacatttgac aaaacc                             1656


<210>  8778
<211>  238
<212>  PRT
<213>  Homosapiens

<400>  8778

Met Ile Gly Pro Ile Ile Asp Lys Leu Glu Lys Val Ala Val Arg Gly 
1               5                   10                  15      


Gly Asp Lys Lys Leu Lys Pro Glu Tyr Asp Ile Met Cys Lys Val Lys 
            20                  25                  30          


Ser Trp Val Ile Asp Gln Lys Lys Pro Val Arg Phe Tyr His Asp Trp 
        35                  40                  45              


Asn Asp Lys Glu Ile Glu Val Leu Asn Lys His Leu Phe Leu Thr Ser 
    50                  55                  60                  


Lys Pro Met Val Tyr Leu Val Asn Leu Ser Glu Lys Asp Tyr Ile Arg 
65                  70                  75                  80  


Lys Lys Asn Lys Trp Leu Ile Lys Ile Lys Glu Trp Val Asp Lys Tyr 
                85                  90                  95      


Asp Pro Gly Ala Leu Val Ile Pro Phe Ser Gly Ala Leu Glu Leu Lys 
            100                 105                 110         


Leu Gln Glu Leu Ser Ala Glu Glu Arg Gln Lys Tyr Leu Glu Ala Asn 
        115                 120                 125             


Met Thr Gln Ser Ala Leu Pro Lys Ile Ile Lys Ala Gly Phe Ala Ala 
    130                 135                 140                 


Leu Gln Leu Glu Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Arg Ala 
145                 150                 155                 160 


Trp Thr Ile Arg Lys Gly Thr Lys Ala Pro Gln Ala Ala Gly Lys Ile 
                165                 170                 175     


His Thr Asp Phe Glu Lys Gly Phe Ile Met Ala Glu Val Met Lys Tyr 
            180                 185                 190         


Glu Asp Phe Lys Glu Glu Gly Ser Glu Asn Ala Val Lys Ala Ala Gly 
        195                 200                 205             


Lys Tyr Arg Gln Gln Gly Arg Asn Tyr Ile Val Glu Asp Gly Asp Ile 
    210                 215                 220                 


Ile Phe Phe Lys Phe Asn Thr Pro Gln Gln Pro Lys Lys Lys 
225                 230                 235             


<210>  8779
<211>  1795
<212>  DNA
<213>  Homosapiens

<400>  8779
ggtctgcgcg caggtgccgc tcggcgcccg gcccgcccgt tccgccgctg tcgccgccgt     60

cgtgcgtgcc gctcggcgga ggggacgggc ctgcgttctc tcctccttcc tccccgcctc    120

cagctgccgg caggaccttt ctctcgctgc cgctgggacc ccgtgtcatc gcccaggccg    180

agcacgatgc cccctaaaaa gggaggtgat ggaattaaac cacccccaat cattggaaga    240

tttggaacct cactgaaaat tggtattgtt ggattgccaa atgttgggaa atctactttc    300

ttcaatgtgt taaccaatag tcaggcttca gcagaaaact tcccgttctg cactattgat    360

cctaatgaga gcagagtacc tgtgccagat gaaaggtttg actttctttg tcaataccac    420

aaaccagcaa gcaaaattcc tgcctttcta aatgtggtgg atattgctgg ccttgtgaaa    480

ggagctcaca atgggcaggg cctggggaat gcttttttat ctcatattag tgcctgtgat    540

ggcatctttc atctaacacg tgcttttgaa gatgatgata tcacgcacgt tgaaggaagt    600

gtagatccta ttcgagatat agaaataata catgaagagc ttcagcttaa agatgaggaa    660

atgattgggc ccattataga taaactagaa aaggtggctg tgagaggagg agataaaaaa    720

ctaaaacctg aatatgatat aatgtgcaaa gtaaaatcct gggttataga tcaaaagaaa    780

cctgttcgct tctatcatga ttggaatgac aaagagattg aagtgttgaa taaacactta    840

tttttgactt caaaaccaat ggtctacttg gttaatcttt ctgaaaaaga ctacattaga    900

aagaaaaaca aatggttgat aaaaattaaa gagtgggtgg acaagtatga cccaggtgct    960

ttggtcattc cttttagtgg ggccttggaa ctcaagttgc aagaattgag tgctgaggag   1020

agacagaagt atctggaagc gaacatgaca caaagtgctt tgccaaagat cattaaggct   1080

gggtttgcag cactccaact agaatacttt ttcactgcag gcccagatga agtgcgtgca   1140

tggaccatca ggaaagggac taaggctcct caggctgcag gaaagattca cacagatttt   1200

gaaaagggat tcattatggc tgaagtaatg aaatacgaag attttaaaga ggaaggttct   1260

gaaaatgcag tcaaggctgc tggaaagtac agacaacaag gcagaaatta tattgttgaa   1320

gatggagata ttatcttctt caaatttaac acacctcaac aaccgaagaa gaaataaaat   1380

ttagttattg ctcagataaa catacaactt ccaaaaggca tctgattttt aaaaaattaa   1440

aatttctgaa aaccaatgcg acaaataaag ttggggagat gggaatcttt gacaaacaaa   1500

ttatttttat ttgttttaaa attaaaatac tgtgtacccc ccccccccca tgaaatgcag   1560

gttcactaaa tgtgaacagc tttgcttttc acgtgattaa gaccctactc caaattgtag   1620

aagcttttca ggaaccatat tactctcatg atacttcatt aatctccatc atgtatgcca   1680

agcctgacac atttgacagt gaggacaatg tggcttgctc ctttttgaat ctacagataa   1740

tgcatgtttt acagtactcc agatgtctac actcaataaa acatttgaca aaacc        1795


<210>  8780
<211>  396
<212>  PRT
<213>  Homosapiens

<400>  8780

Met Pro Pro Lys Lys Gly Gly Asp Gly Ile Lys Pro Pro Pro Ile Ile 
1               5                   10                  15      


Gly Arg Phe Gly Thr Ser Leu Lys Ile Gly Ile Val Gly Leu Pro Asn 
            20                  25                  30          


Val Gly Lys Ser Thr Phe Phe Asn Val Leu Thr Asn Ser Gln Ala Ser 
        35                  40                  45              


Ala Glu Asn Phe Pro Phe Cys Thr Ile Asp Pro Asn Glu Ser Arg Val 
    50                  55                  60                  


Pro Val Pro Asp Glu Arg Phe Asp Phe Leu Cys Gln Tyr His Lys Pro 
65                  70                  75                  80  


Ala Ser Lys Ile Pro Ala Phe Leu Asn Val Val Asp Ile Ala Gly Leu 
                85                  90                  95      


Val Lys Gly Ala His Asn Gly Gln Gly Leu Gly Asn Ala Phe Leu Ser 
            100                 105                 110         


His Ile Ser Ala Cys Asp Gly Ile Phe His Leu Thr Arg Ala Phe Glu 
        115                 120                 125             


Asp Asp Asp Ile Thr His Val Glu Gly Ser Val Asp Pro Ile Arg Asp 
    130                 135                 140                 


Ile Glu Ile Ile His Glu Glu Leu Gln Leu Lys Asp Glu Glu Met Ile 
145                 150                 155                 160 


Gly Pro Ile Ile Asp Lys Leu Glu Lys Val Ala Val Arg Gly Gly Asp 
                165                 170                 175     


Lys Lys Leu Lys Pro Glu Tyr Asp Ile Met Cys Lys Val Lys Ser Trp 
            180                 185                 190         


Val Ile Asp Gln Lys Lys Pro Val Arg Phe Tyr His Asp Trp Asn Asp 
        195                 200                 205             


Lys Glu Ile Glu Val Leu Asn Lys His Leu Phe Leu Thr Ser Lys Pro 
    210                 215                 220                 


Met Val Tyr Leu Val Asn Leu Ser Glu Lys Asp Tyr Ile Arg Lys Lys 
225                 230                 235                 240 


Asn Lys Trp Leu Ile Lys Ile Lys Glu Trp Val Asp Lys Tyr Asp Pro 
                245                 250                 255     


Gly Ala Leu Val Ile Pro Phe Ser Gly Ala Leu Glu Leu Lys Leu Gln 
            260                 265                 270         


Glu Leu Ser Ala Glu Glu Arg Gln Lys Tyr Leu Glu Ala Asn Met Thr 
        275                 280                 285             


Gln Ser Ala Leu Pro Lys Ile Ile Lys Ala Gly Phe Ala Ala Leu Gln 
    290                 295                 300                 


Leu Glu Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Arg Ala Trp Thr 
305                 310                 315                 320 


Ile Arg Lys Gly Thr Lys Ala Pro Gln Ala Ala Gly Lys Ile His Thr 
                325                 330                 335     


Asp Phe Glu Lys Gly Phe Ile Met Ala Glu Val Met Lys Tyr Glu Asp 
            340                 345                 350         


Phe Lys Glu Glu Gly Ser Glu Asn Ala Val Lys Ala Ala Gly Lys Tyr 
        355                 360                 365             


Arg Gln Gln Gly Arg Asn Tyr Ile Val Glu Asp Gly Asp Ile Ile Phe 
    370                 375                 380                 


Phe Lys Phe Asn Thr Pro Gln Gln Pro Lys Lys Lys 
385                 390                 395     


<210>  8781
<211>  1490
<212>  DNA
<213>  Homosapiens

<400>  8781
gcgcaggtgc cgctcggcgc ccggcccgcc cgttccgccg ctgtcgccgc cgtcgtgcgt     60

gccgctcggc ggaggggacg ggcctgcgtt ctctcctcct tcctccccgc ctccagctgc    120

cggcaggacc tttctctcgc tgccgctggg accccgtgtc atcgcccagg ccgagcacga    180

tgccccctaa aaagggaggt gatggaatta aaccaccccc aatcattgga agatttggaa    240

cctcactgaa aattggtatt gttggattgc caaatgttgg gaaatctact ttcttcaatg    300

tgttaaccaa tagtcaggct tcagcagaaa acttcccgtt ctgcactatt gatcctaatg    360

agagcagagt acctgtgcca gatgaaaggt ttgactttct ttgtcaatac cacaaaccag    420

caagcaaaat tcctgccttt ctaaatgtgg tggatattgc tggccttgtg aaaggagctc    480

acaatgggca gggcctgggg aatgcttttt tatctcatat tagtgcctgt gatggcatct    540

ttcatctaac acgtgctttt gaagatgatg atatcacgca cgttgaagga agtgtagatc    600

ctattcgaga tatagaaata atacatgaag agcttcagct taaagatgag gaaatgattg    660

ggcccattat agataaacta gaaaaggtgg ctgtgagagg aggagataaa aaactaaaac    720

ctgaatatga tataatgtgc aaagtaaaat cctgggttat agatcaaaag aaacctgttc    780

gcttctatca tgattggaat gacaaagaga ttgaagtgtt gaataaacac ttatttttga    840

cttcaaaacc aatggtctac ttggttaatc tttctgaaaa agactacatt agaaagaaaa    900

acaaatggtt gataaaaatt aaagagtggg tggacaagta tgacccaggt gctttggtca    960

ttccttttag tggggccttg gaactcaagt tgcaagaatt gagtgctgag gagagacaga   1020

agtatctgga agcgaacatg acacaaagtg ctttgccaaa gatcattaag gctgggtttg   1080

cagcactcca actagaatac tttttcactg caggcccaga tgaagtgcgt gcatggacca   1140

tcaggaaagg gactaaggct cctcaggctg caggaaagat tcacacagat tttgaaaagg   1200

gattcattat ggctgaagta atgaaatacg aagattttaa agaggaaggt tctgaaaatg   1260

cagtcaaggc tgctggaaag tacagacaac aaggcagaaa ttatattgtt gaagatggag   1320

atattatctt cttcaaattt aacacacctc aacaaccgaa gaagaaataa aatttagtta   1380

ttgctcagat aaacatacaa cttccaaaag gcatctgatt tttaaaaaat taaaatttct   1440

gaaaaccaat gcgacaaata aagttgggga gatgggaatc tttgacaaac              1490


<210>  8782
<211>  396
<212>  PRT
<213>  Homosapiens

<400>  8782

Met Pro Pro Lys Lys Gly Gly Asp Gly Ile Lys Pro Pro Pro Ile Ile 
1               5                   10                  15      


Gly Arg Phe Gly Thr Ser Leu Lys Ile Gly Ile Val Gly Leu Pro Asn 
            20                  25                  30          


Val Gly Lys Ser Thr Phe Phe Asn Val Leu Thr Asn Ser Gln Ala Ser 
        35                  40                  45              


Ala Glu Asn Phe Pro Phe Cys Thr Ile Asp Pro Asn Glu Ser Arg Val 
    50                  55                  60                  


Pro Val Pro Asp Glu Arg Phe Asp Phe Leu Cys Gln Tyr His Lys Pro 
65                  70                  75                  80  


Ala Ser Lys Ile Pro Ala Phe Leu Asn Val Val Asp Ile Ala Gly Leu 
                85                  90                  95      


Val Lys Gly Ala His Asn Gly Gln Gly Leu Gly Asn Ala Phe Leu Ser 
            100                 105                 110         


His Ile Ser Ala Cys Asp Gly Ile Phe His Leu Thr Arg Ala Phe Glu 
        115                 120                 125             


Asp Asp Asp Ile Thr His Val Glu Gly Ser Val Asp Pro Ile Arg Asp 
    130                 135                 140                 


Ile Glu Ile Ile His Glu Glu Leu Gln Leu Lys Asp Glu Glu Met Ile 
145                 150                 155                 160 


Gly Pro Ile Ile Asp Lys Leu Glu Lys Val Ala Val Arg Gly Gly Asp 
                165                 170                 175     


Lys Lys Leu Lys Pro Glu Tyr Asp Ile Met Cys Lys Val Lys Ser Trp 
            180                 185                 190         


Val Ile Asp Gln Lys Lys Pro Val Arg Phe Tyr His Asp Trp Asn Asp 
        195                 200                 205             


Lys Glu Ile Glu Val Leu Asn Lys His Leu Phe Leu Thr Ser Lys Pro 
    210                 215                 220                 


Met Val Tyr Leu Val Asn Leu Ser Glu Lys Asp Tyr Ile Arg Lys Lys 
225                 230                 235                 240 


Asn Lys Trp Leu Ile Lys Ile Lys Glu Trp Val Asp Lys Tyr Asp Pro 
                245                 250                 255     


Gly Ala Leu Val Ile Pro Phe Ser Gly Ala Leu Glu Leu Lys Leu Gln 
            260                 265                 270         


Glu Leu Ser Ala Glu Glu Arg Gln Lys Tyr Leu Glu Ala Asn Met Thr 
        275                 280                 285             


Gln Ser Ala Leu Pro Lys Ile Ile Lys Ala Gly Phe Ala Ala Leu Gln 
    290                 295                 300                 


Leu Glu Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Arg Ala Trp Thr 
305                 310                 315                 320 


Ile Arg Lys Gly Thr Lys Ala Pro Gln Ala Ala Gly Lys Ile His Thr 
                325                 330                 335     


Asp Phe Glu Lys Gly Phe Ile Met Ala Glu Val Met Lys Tyr Glu Asp 
            340                 345                 350         


Phe Lys Glu Glu Gly Ser Glu Asn Ala Val Lys Ala Ala Gly Lys Tyr 
        355                 360                 365             


Arg Gln Gln Gly Arg Asn Tyr Ile Val Glu Asp Gly Asp Ile Ile Phe 
    370                 375                 380                 


Phe Lys Phe Asn Thr Pro Gln Gln Pro Lys Lys Lys 
385                 390                 395     


<210>  8783
<211>  3120
<212>  DNA
<213>  Homosapiens

<400>  8783
cagagaaaga ggaaccagaa gaaagagaaa ctcgcgacaa cagagttgcc gaaagagaag     60

tgttggcgcc tcaaacttga ggatcagctt cttgggcccc actccagggt gtcgcggggg    120

tcgggttctt tccgccgccc cccgaaagat tctcagctaa ccctttcccc gccgagacca    180

agaggccctc actctgacac cactccggga gccaagctac tgtaaggagc tgataccacc    240

cctcgccggc gcgaaccgcc catctcccca gacccgccca ccccctgctg cgaatccctg    300

acgttctagc ccggcgaagg tcctcttaaa ttaggaaaca atagctattt aagaagaagc    360

gcaaataacc cgcgctctgc gcgcccaatc gtgggattct tgggagttcc ccgcgggcaa    420

ggaagtctgc tgctccccgc agctgcggag gagaggaggg agcctgcgtg ctggggcagg    480

gtgtcgcgaa cttggggcaa cccacctcca gagccccgcc cccgctttcc cgcctgccgg    540

ggacctgccg aacgcggaac caccctcctt cctgaggcaa atttgggagg ggagaggtcc    600

agaagctgta gagtcggggc gccaagcgcc agattctgcc gctcggaagt tgggggcagt    660

ccccagtccc gcctcaggcc cccgcgctca cagggcgctc cgccgagggc gcgggccagg    720

cgcgcggtgt cacctccacg aagtcattta cttgccctga aggagctggc cctcgacccc    780

ttggaggatg gagattcctc ccattccctc ctccgcctcc cccaggtcgg cgaagagacg    840

tggaattgag ctggaccgat gattccgcga gctctgtaat tatgcacaca ctgaaatctt    900

caccgttgac ttaagttact tggcgctgcg agggctgggg ccctgcatat tgattaaatg    960

cagcctctat ttacctaaac aataaatgta gagattagca acgttcactt gatcacaata   1020

atgggattga caattaaggg gcaatgcatc ccagatgtag cggaacctat gggctgcgtg   1080

cagcaggcag agggcttctc agagaggggc gctgggcagt tgcggcggcg gaggtagtgc   1140

agagcaggaa gcagcgcgga agcacagcgg gaggcggagg gggacgccca gcctcgtcaa   1200

ggtcttcggc caccccgccc gggaggctcg aaactggctt tggggtacct gaatgcctcg   1260

actcccaggg agacatcggg agctcggagc cactctccct gtggcgatgg cacctgcctc   1320

aaggccgtct cgcttgctga tgcctggccg ggaaggagga tggacgccgc tggcatgtgc   1380

cctggctctg gaaaaactgg caggaatttc cttgtcgtga gaagatggac gagtgtgtct   1440

gcagccgagg agacaactac aaacagactt tgggcaggga aggcgggcgg gcgggggtgg   1500

gggtgggggc gggggcctgc tttgatcgct ccagctctgt tgtaattttg tcttcgccag   1560

atagattagc tggaaccgcc agccctagct tggagttccg ttccacggag taccctccct   1620

ccccaccccc agcgtcatct cgcgcctgga gccgggtcgc cgctccttcc gaagtctcgc   1680

tggaaacttc aagggctgat ggttctgtgt tcttgacgta attaggaggc cacgcagctc   1740

tccaacactc cgttaaacaa atatactcct gcaggctcag atttgaagag ggaaggttcc   1800

agccaagtcc accttaagcc tgagtttggg cgactacaga atccaggaag aaaatctaga   1860

tggcatggtc gctccggtct cagttctaca ggggagggaa gaaagggggt gttagtgggg   1920

atatttgctg ttcatttttc ccgcaatctc ccttccaaat cagtcactga ttaatgagca   1980

aagcccatgc cacaagttat agattactgt ggactgagga tcattttgtt aatatcaggc   2040

aagaaacttg ccttacttgc atccctgtgt ctgtatttac agtaacaact tccttagtca   2100

caaactgata tgcttttagc catacctttt cttcttactt acttattttt agcatcatca   2160

ggagttggga taggaaataa catgggggag gggtgtgtta aagggaagga aggaaaagcc   2220

atcctttatc ccagagtgtc ctggaggtat gcctacactc ctgtttaaca tcttgtggtt   2280

gtagtgcctt ctccaagccc tggatggagg aggaaagagt tggaagcctc ctcaaatctg   2340

cctatgaaag ggtaaaactg aggaaactgg taccctagct atgagaagct gagtaatgat   2400

cagaatcctc tggcctctgg cttttcttga tattagttca ggtctatgca aaaaaattgc   2460

tttagtgtct ccaaaggtgg ttccattaga gttggctgag acaatacatg tgcatcattt   2520

tggaagagat gctcttaaaa agaagaaagc cactacagaa tgccacattt gcttaggtct   2580

aagacccttc tgtggtagtc ggtgagggag ggaggaaagt aaaaccccaa gctgaatagg   2640

ccccccatag tttccgagtg atgcagtaaa caaatctatg atgcttgttg aataatcttc   2700

caataattgc agtcattaaa atcatcacac agtctacagt caccttcctt cctttgacac   2760

accagtcttt cccttaattg ttaatgcatt tttggctcag ataaacacat agaggccagc   2820

ttaaaatata tggcccagat acatctaaca gcagaaaatt agttgtgtaa caaacgtttg   2880

gactgtgctt aatagactag gggttttcaa tttcttcagc agaccctaca gaggcaagaa   2940

agatttgcat cttctaccac tgctaaatag cagtgacgcc tctgagatac aaaaaaaaaa   3000

aaaaaagaaa aaaaagatga aagtcccatt ggcctattga atcttccttg ctctttcatt   3060

tgcaagggtt gggctggaat taggacatta tagaacaaat attaaaggaa agcttaacag   3120


<210>  8784
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  8784

Met Asp Ala Ala Gly Met Cys Pro Gly Ser Gly Lys Thr Gly Arg Asn 
1               5                   10                  15      


Phe Leu Val Val Arg Arg Trp Thr Ser Val Ser Ala Ala Glu Glu Thr 
            20                  25                  30          


Thr Thr Asn Arg Leu Trp Ala Gly Lys Ala Gly Gly Arg Gly Trp Gly 
        35                  40                  45              


Trp Gly Arg Gly Pro Ala Leu Ile Ala Pro Ala Leu Leu 
    50                  55                  60      


<210>  8785
<211>  1603
<212>  DNA
<213>  Homosapiens

<400>  8785
tggttctgtg ttcttgacgt aattaggagg ccacgcagct ctccaacact ccgttaaaca     60

aatatctctt tcttaggaag cggagagagg ggcagaaaac gtgcacctcg ccacccaccg    120

gacaagccga gaggaccttg tctttgcttg aaaagttttc tagataaatc gctcgggtgg    180

ttctaagcta tgacgaacta gaggctgggc ccggttcttc tccagaacag cgtgtggatg    240

taaaggagat gaaatcgtcc tcccccactg ctttcttttt cttccccata taaatcagtc    300

atataattca ttcgcattgt ttaaggtaca ttgatcaatc taatggcttg taatagtctc    360

ctaattgcca cttgcagact cctgcaggct cagatttgaa gagggaaggt tccagccaag    420

tccaccttaa gcctgagttt gggcgactac agaatccagg aagaaaatct agatggcatg    480

gtcgctccgg tctcagttct acaggggagg gaagaaaggg ggtgttagtg gggatatttg    540

ctgttcattt ttcccgcaat ctcccttcca aatcagtcac tgattaatga gcaaagccca    600

tgccacaagt tatagattac tgtggactga ggatcatttt gttaatatca ggcaagaaac    660

ttgccttact tgcatccctg tgtctgtatt tacagtaaca acttccttag tcacaaactg    720

atatgctttt agccatacct tttcttctta cttacttatt tttagcatca tcaggagttg    780

ggataggaaa taacatgggg gaggggtgtg ttaaagggaa ggaaggaaaa gccatccttt    840

atcccagagt gtcctggagg tatgcctaca ctcctgttta acatcttgtg gttgtagtgc    900

cttctccaag ccctggatgg aggaggaaag agttggaagc ctcctcaaat ctgcctatga    960

aagggtaaaa ctgaggaaac tggtacccta gctatgagaa gctgagtaat gatcagaatc   1020

ctctggcctc tggcttttct tgatattagt tcaggtctat gcaaaaaaat tgctttagtg   1080

tctccaaagg tggttccatt agagttggct gagacaatac atgtgcatca ttttggaaga   1140

gatgctctta aaaagaagaa agccactaca gaatgccaca tttgcttagg tctaagaccc   1200

ttctgtggta gtcggtgagg gagggaggaa agtaaaaccc caagctgaat aggcccccca   1260

tagtttccga gtgatgcagt aaacaaatct atgatgcttg ttgaataatc ttccaataat   1320

tgcagtcatt aaaatcatca cacagtctac agtcaccttc cttcctttga cacaccagtc   1380

tttcccttaa ttgttaatgc atttttggct cagataaaca catagaggcc agcttaaaat   1440

atatggccca gatacatcta acagcagaaa attagttgtg taacaaacgt ttggactgtg   1500

cttaatagac taggggtttt caatttcttc agcagaccct acagaggcaa gaaagatttg   1560

catcttctac cactgctaaa tagcagtgac gcctctgaga tac                     1603


<210>  8786
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  8786

Met Ile Arg Ile Leu Trp Pro Leu Ala Phe Leu Asp Ile Ser Ser Gly 
1               5                   10                  15      


Leu Cys Lys Lys Ile Ala Leu Val Ser Pro Lys Val Val Pro Leu Glu 
            20                  25                  30          


Leu Ala Glu Thr Ile His Val His His Phe Gly Arg Asp Ala Leu Lys 
        35                  40                  45              


Lys Lys Lys Ala Thr Thr Glu Cys His Ile Cys Leu Gly Leu Arg Pro 
    50                  55                  60                  


Phe Cys Gly Ser Arg 
65                  


<210>  8787
<211>  3129
<212>  DNA
<213>  Homosapiens

<400>  8787
gtgtgctcgc gcctctcgcc cggcctctaa gagtcgttgg ggccagacgc tgcttccttg     60

cctcccgcgg aggccgccgc cgccgccgcc gccgctgccg ccgccgccgc tgccgccgcc    120

cgggcggcac tgacgccgga gtcatgcagg atgaggtcgg gggattcgga acggggcgtc    180

tccaggttgc tggcgtccgt gtcactgtcg ctgccctttt tgcccccgcc gcccccgttg    240

tgcgtcttaa tgtgtttgct caggtggtcg ctgcgcatga agcgcttgtt gcacaccgga    300

caggcgaagc gcttctcgcc cgtgtgagtc cgcagatgcc gctgcagctc gtccgagcgc    360

gtgaagcgct tgccgcagaa gagccagttg cacacgaagg gccgctcgcc cgtgtgccag    420

cgcaggtgcg ccttcaggtg cgacgtcttc ccgtacacct tgccgcagcc cggaatgtgg    480

cagctgtgca ggcccttgcg ccgcaggctc gccccggccg ggcccagccg ctccgcctcc    540

tggcagttgg ggcagtcgca ggtggcgcgg cccgagtagc ggcgggcaga gcgtgccgag    600

ctccccccgg cggcggcagc cgcggcgccc gatatcatgg cgctggcggc ggcggctgcc    660

acggcggcgc tggagtccga ataggagggc aacaccggct tgaagccgtc ctgggccagc    720

aggtgctggc tggtggagag caggtgggag gcggcggcgg cggaggagcc gaggcccgtg    780

gagctgaagg cggagtgcgt gagcgagctg aagtcggggt tgtaggtgcc cagctgcgag    840

tgcagcgagg cctggggggc gcccgagtgc agcgagctct ggagcccccc agcggggttc    900

tgcacttcca gccacgagcc cgggctgctg tgcacgtccc accacgacga cgccgcgccg    960

ttggtcacct cgccggccgc cagcgtcgaa tggaagcccg acttgtacca ggactcgtac   1020

gggtgcgcca tgcccacgcg cgggtacagc ccgtcggctg ccgtcgtgtg caccttggaa   1080

atgaaggccg actggccacc cgcctcctgc ggggacaccc cggccgctgc cgccgcggca   1140

gccgccgagt tggagaagag gccgccgtag tcgctgctga aggcggacga cgtgggcgac   1200

gtggaggcca ggcagaaggc gctgttggcg gcgcccgagc cgcccgccag gccgcccgag   1260

ccacggcccc cggtggccac cgcgaagccc gagaggctgg agccgaggtt gcagctggac   1320

gaggagcgct tccaggggtg aaagccgcct ttggcgaagg cgctcgactc tggcagcgtc   1380

gtcagcgggc tcgtgttgcc gatcttgttg caggtcgccg ccagcatggc caacggggtc   1440

gttccgaagc gcggctcttc ctagagtggg tgggatgggg gagggagcaa gaaggaggag   1500

ggcaagagga agtgggggaa gaaacaaagt gcacccgtga gcagcctcgt cccctgcggc   1560

tgctcccggg gggtcctggc tccccgcctc gcgcctcctc cccacgcgcc cgcggaggag   1620

tcgccgcacc gggcgcggag caggggcgat cacccgggcg aaggtccagg cgccggaaag   1680

ttgcacttcg ctgaggctat aaatcaaaga tgcctccgtg ttccccgctg caaccctgcc   1740

tacaaccgga cttgggttgt cgccgtaaac cggctcatct cccagaagac cccaagtcgc   1800

ccttcggggt gaagcgcgaa ggtaaacaca gagaccagag acaacaaaca ccgggtgagg   1860

gcggaggcgg ccgaaacagc tgccagggac gggcgaaact tgcagctctc ccagggtggc   1920

tacgacttga cttttctttt ttaatagaaa acgtttggtt ttaaagttta catacacaca   1980

aaaacagcga ttatgaaaac aataatccga ggataagcgg ccagagacag atttcaaagt   2040

catgggcgaa ttggggagcc gcggaaatgt aaatgtttat tagcgtgact agatggactg   2100

caaaacgatt aagactgttt tctggaaaca ccattgtcgc ataattgcaa caaaatcccc   2160

aaagcaatgc gggggatggg gtataaatca cgaggggaag aaaagaaacc tctagctttt   2220

ttttgaaacc aaatgaaaaa ggacttgatt aagaaggcct tttcttgcaa aggcatcttt   2280

ctgggttcca aaaacttggg gaaaaatcag tcccagaaat gtggaaagtg ctaatagaag   2340

ctgaagctgc agtctagcag caacagtttc tccggagccg cagaccccag aagccataac   2400

gaaaaattac tccggttaaa acaagcaaat gcgttgccgc gcttgcgact taccccgagt   2460

atagacgtgg ccatagcagg tctctggctg cgcagcgagg ctgggagcgg ggctgagcct   2520

ggcggctgct cggaaaaact gcttgggtcc cgcgcggctc ccgcgtcccc gcgctcgtgc   2580

cgagcggact ccaggctccc gccggctaaa ctcagcctaa gtgcgaggag cacccgcttt   2640

gaagtgccgc tggctgcgcc tctcgcccaa tgagggcgca ggcagagcag accggagctg   2700

ccccgcagcc aatcagacgc tccgaggggc ccgagcccgg gctcccggcg cgtgccagtc   2760

aagtcagcta gctagggccg cgggggtggg ggggagtagt gggggatact tgcggggggg   2820

gggcgagggc gggctgggga ctgaagaaat tacagtgcaa ttaaaaattt acactcacgc   2880

accaagccag gtttaagtac caatgaaacc gagccacaag caccccccca cacacaaacc   2940

accccgagat gttgcaagtt agggctgaca gtcctactcg actccccact tgtaggaaag   3000

gaggcaggag gggaggagac acccagacac agcccgcacc agcagggccc aagtggagac   3060

ggaaatgtga gccctcactt tgtgtgtcca ggcttttgcc tacagaacac aacttcagct   3120

tgtatctat                                                           3129


<210>  8788
<211>  516
<212>  PRT
<213>  Homosapiens

<400>  8788

Met Gln Asp Glu Val Gly Gly Phe Gly Thr Gly Arg Leu Gln Val Ala 
1               5                   10                  15      


Gly Val Arg Val Thr Val Ala Ala Leu Phe Ala Pro Ala Ala Pro Val 
            20                  25                  30          


Val Arg Leu Asn Val Phe Ala Gln Val Val Ala Ala His Glu Ala Leu 
        35                  40                  45              


Val Ala His Arg Thr Gly Glu Ala Leu Leu Ala Arg Val Ser Pro Gln 
    50                  55                  60                  


Met Pro Leu Gln Leu Val Arg Ala Arg Glu Ala Leu Ala Ala Glu Glu 
65                  70                  75                  80  


Pro Val Ala His Glu Gly Pro Leu Ala Arg Val Pro Ala Gln Val Arg 
                85                  90                  95      


Leu Gln Val Arg Arg Leu Pro Val His Leu Ala Ala Ala Arg Asn Val 
            100                 105                 110         


Ala Ala Val Gln Ala Leu Ala Pro Gln Ala Arg Pro Gly Arg Ala Gln 
        115                 120                 125             


Pro Leu Arg Leu Leu Ala Val Gly Ala Val Ala Gly Gly Ala Ala Arg 
    130                 135                 140                 


Val Ala Ala Gly Arg Ala Cys Arg Ala Pro Pro Gly Gly Gly Ser Arg 
145                 150                 155                 160 


Gly Ala Arg Tyr His Gly Ala Gly Gly Gly Gly Cys His Gly Gly Ala 
                165                 170                 175     


Gly Val Arg Ile Gly Gly Gln His Arg Leu Glu Ala Val Leu Gly Gln 
            180                 185                 190         


Gln Val Leu Ala Gly Gly Glu Gln Val Gly Gly Gly Gly Gly Gly Gly 
        195                 200                 205             


Ala Glu Ala Arg Gly Ala Glu Gly Gly Val Arg Glu Arg Ala Glu Val 
    210                 215                 220                 


Gly Val Val Gly Ala Gln Leu Arg Val Gln Arg Gly Leu Gly Gly Ala 
225                 230                 235                 240 


Arg Val Gln Arg Ala Leu Glu Pro Pro Ser Gly Val Leu His Phe Gln 
                245                 250                 255     


Pro Arg Ala Arg Ala Ala Val His Val Pro Pro Arg Arg Arg Arg Ala 
            260                 265                 270         


Val Gly His Leu Ala Gly Arg Gln Arg Arg Met Glu Ala Arg Leu Val 
        275                 280                 285             


Pro Gly Leu Val Arg Val Arg His Ala His Ala Arg Val Gln Pro Val 
    290                 295                 300                 


Gly Cys Arg Arg Val His Leu Gly Asn Glu Gly Arg Leu Ala Thr Arg 
305                 310                 315                 320 


Leu Leu Arg Gly His Pro Gly Arg Cys Arg Arg Gly Ser Arg Arg Val 
                325                 330                 335     


Gly Glu Glu Ala Ala Val Val Ala Ala Glu Gly Gly Arg Arg Gly Arg 
            340                 345                 350         


Arg Gly Gly Gln Ala Glu Gly Ala Val Gly Gly Ala Arg Ala Ala Arg 
        355                 360                 365             


Gln Ala Ala Arg Ala Thr Ala Pro Gly Gly His Arg Glu Ala Arg Glu 
    370                 375                 380                 


Ala Gly Ala Glu Val Ala Ala Gly Arg Gly Ala Leu Pro Gly Val Lys 
385                 390                 395                 400 


Ala Ala Phe Gly Glu Gly Ala Arg Leu Trp Gln Arg Arg Gln Arg Ala 
                405                 410                 415     


Arg Val Ala Asp Leu Val Ala Gly Arg Arg Gln His Gly Gln Arg Gly 
            420                 425                 430         


Arg Ser Glu Ala Arg Leu Phe Leu Glu Trp Val Gly Trp Gly Arg Glu 
        435                 440                 445             


Gln Glu Gly Gly Gly Gln Glu Glu Val Gly Glu Glu Thr Lys Cys Thr 
    450                 455                 460                 


Arg Glu Gln Pro Arg Pro Leu Arg Leu Leu Pro Gly Gly Pro Gly Ser 
465                 470                 475                 480 


Pro Pro Arg Ala Ser Ser Pro Arg Ala Arg Gly Gly Val Ala Ala Pro 
                485                 490                 495     


Gly Ala Glu Gln Gly Arg Ser Pro Gly Arg Arg Ser Arg Arg Arg Lys 
            500                 505                 510         


Val Ala Leu Arg 
        515     


<210>  8789
<211>  1015
<212>  DNA
<213>  Homosapiens

<400>  8789
aaaaaagaaa aaagatagaa aaaagaaaaa gtttcagaag agcagaaaaa aatacaaagg     60

aagaaaagaa agaaaaacaa gtgttcaggg cataacaaca gtgattctga agagaaggac    120

aagtctaaga agagaaagct tcatgaagaa ctttctagca gtcaccataa ccgggaaaaa    180

gccaaggaaa agcccaggtt cttaaaacac gagagttcta gggaggacag caaatggagc    240

cattctgatt ctgacaaaaa gtccagaacc cataaacata gcccagagaa gagaggctct    300

gaaagaaagg aggggagcag cagaagccac ggcagggagg aaaggagccg gagaagccgg    360

agcagaagtc ctggtagtta caagcaaagg gagacaagga aacgggcaca gcgaaatcct    420

ggtgaagagc aaagcagaag aaatgacagc agaagccatg gcacagactt gtatagagga    480

gaaaaaatgt acagagagca cccaggaggt acacatacta aagtgacaca aagagaatga    540

agcagaagta gagaagaaag actgtatgtg acaattacct gggaataaaa atatctccac    600

ttttttattg aataccttta gcaaggggta aattatgtac tgttgtcttt ctaataaaaa    660

agctcaattt taatttttca tctctagact gtcaattcaa gtacaaaact acatgagtac    720

tataagaatg aattttgcaa atatttgtaa gtaagctatt ttggggctgt ggaaatattt    780

tctgttggta actgtttctt gttccccata ccagataaaa accgcatata actctgtgac    840

attttctttg ttctgaaaca tcattaaaag aatgacagta cattgaatgg gtataattta    900

cttttttcaa ttcaaatttg ttattctagg atttgaattt gcttgaagtg aattgtaata    960

attattcaaa ttcattagta taaattaagg attaataaat ctttaagact tttaa        1015


<210>  8790
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  8790

Lys Arg Lys Lys Ile Glu Lys Arg Lys Ser Phe Arg Arg Ala Glu Lys 
1               5                   10                  15      


Asn Thr Lys Glu Glu Lys Lys Glu Lys Gln Val Phe Arg Ala 
            20                  25                  30  


<210>  8791
<211>  1919
<212>  DNA
<213>  Homosapiens

<400>  8791
cttgctgctg gaaacgcagt tccggttagg cggctgagtt tgtttacgtt gctaacagat     60

ctagcccctg ctttccctag ttccagttcc aagatgggga aatccttcgc caacttcatg    120

tgcaagaaag actttcatcc tgcctccaaa tccaatatca aaaaagtatg gatggcagaa    180

cagaaaatat catatgataa gaagaaacaa gaagaattga tgcagcaata tcttaaagaa    240

caagaatcat atgataatag attgcttatg ggagatgaac gtgtaaagaa tggccttaat    300

ttcatgtatg aagccccacc aggagctaaa aaaggtactt atcaaagaag aaacagaagg    360

agagaccgaa tacaaatttg aatggcagaa aggagcccca cgagaaaaat atgccaaaga    420

tgacatgaac atcagagatc agccctttgg tattcaggtt cgaaatgtga ggtgcattaa    480

atgtcacaaa tggggtcatg tcaacacaga tcgagaatgt cctttgtttg gtctttctgg    540

aatcaatgca agttcggttc ccactgatgg ctcagggcca tcgatgcacc cctcggagct    600

aatagcggag atgagaaaca gtgggtttgc actgaaacga aatgtactgg ggagaaactt    660

gaccgcaaat gatccatcac aggagtatgt tgcaagtgag ggtgaagaag atccagaagt    720

tgaattttta aagtcactaa caaccaaaca aaaacagaaa cttctcagga aattagatcg    780

actggagaag aaaaaaaaga aaaaagatag aaaaaagaaa aagtttcaga agagcagaag    840

taaacacaaa aaacataagt cctcttcttc ctcatcttcc tcctcctcct cctcttcctc    900

tactgagact tcagaaagca gtagtgagag tgagagtaac aataaagaaa aaaaaataca    960

aaggaagaaa agaaagaaaa acaagtgttc agggcataac aacagtgatt ctgaagagaa   1020

ggacaagtct aagaagagaa agcttcatga agaactttct agcagtcacc ataaccggga   1080

aaaagccaag gaaaagccca ggttcttaaa acacgagagt tctagggagg acagcaaatg   1140

gagccattct gattctgaca aaaagtccag aacccataaa catagcccag agaagagagg   1200

ctctgaaaga aaggagggga gcagcagaag ccacggcagg gaggaaagga gccggagaag   1260

ccggagcaga agtcctggta gttacaagca aagggagaca aggaaacggg cacagcgaaa   1320

tcctggtgaa gagcaaagca gaagaaatga cagcagaagc catggcacag acttgtatag   1380

aggagaaaaa atgtacagag agcacccagg aggtacacat actaaagtga cacaaagaga   1440

atgaagcaga agtagagaag aaagactgta tgtgacaatt acctgggaat aaaaatatct   1500

ccactttttt attgaatacc tttagcaagg ggtaaattat gtactgttgt ctttctaata   1560

aaaaagctca attttaattt ttcatctcta gactgtcaat tcaagtacaa aactacatga   1620

gtactataag aatgaatttt gcaaatattt gtaagtaagc tattttgggg ctgtggaaat   1680

attttctgtt ggtaactgtt tcttgttccc cataccagat aaaaaccgca tataactctg   1740

tgacattttc tttgttctga aacatcatta aaagaatgac agtacattga atgggtataa   1800

tttacttttt tcaattcaaa tttgttattc taggatttga atttgcttga agtgaattgt   1860

aataattatt caaattcatt agtataaatt aaggattaat aaatctttaa gacttttaa    1919


<210>  8792
<211>  384
<212>  PRT
<213>  Homosapiens

<400>  8792

Met Ala Leu Ile Ser Cys Met Lys Pro His Gln Glu Leu Lys Lys Val 
1               5                   10                  15      


Leu Ile Lys Glu Glu Thr Glu Gly Glu Thr Glu Tyr Lys Phe Glu Trp 
            20                  25                  30          


Gln Lys Gly Ala Pro Arg Glu Lys Tyr Ala Lys Asp Asp Met Asn Ile 
        35                  40                  45              


Arg Asp Gln Pro Phe Gly Ile Gln Val Arg Asn Val Arg Cys Ile Lys 
    50                  55                  60                  


Cys His Lys Trp Gly His Val Asn Thr Asp Arg Glu Cys Pro Leu Phe 
65                  70                  75                  80  


Gly Leu Ser Gly Ile Asn Ala Ser Ser Val Pro Thr Asp Gly Ser Gly 
                85                  90                  95      


Pro Ser Met His Pro Ser Glu Leu Ile Ala Glu Met Arg Asn Ser Gly 
            100                 105                 110         


Phe Ala Leu Lys Arg Asn Val Leu Gly Arg Asn Leu Thr Ala Asn Asp 
        115                 120                 125             


Pro Ser Gln Glu Tyr Val Ala Ser Glu Gly Glu Glu Asp Pro Glu Val 
    130                 135                 140                 


Glu Phe Leu Lys Ser Leu Thr Thr Lys Gln Lys Gln Lys Leu Leu Arg 
145                 150                 155                 160 


Lys Leu Asp Arg Leu Glu Lys Lys Lys Lys Lys Lys Asp Arg Lys Lys 
                165                 170                 175     


Lys Lys Phe Gln Lys Ser Arg Ser Lys His Lys Lys His Lys Ser Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Glu Thr Ser 
        195                 200                 205             


Glu Ser Ser Ser Glu Ser Glu Ser Asn Asn Lys Glu Lys Lys Ile Gln 
    210                 215                 220                 


Arg Lys Lys Arg Lys Lys Asn Lys Cys Ser Gly His Asn Asn Ser Asp 
225                 230                 235                 240 


Ser Glu Glu Lys Asp Lys Ser Lys Lys Arg Lys Leu His Glu Glu Leu 
                245                 250                 255     


Ser Ser Ser His His Asn Arg Glu Lys Ala Lys Glu Lys Pro Arg Phe 
            260                 265                 270         


Leu Lys His Glu Ser Ser Arg Glu Asp Ser Lys Trp Ser His Ser Asp 
        275                 280                 285             


Ser Asp Lys Lys Ser Arg Thr His Lys His Ser Pro Glu Lys Arg Gly 
    290                 295                 300                 


Ser Glu Arg Lys Glu Gly Ser Ser Arg Ser His Gly Arg Glu Glu Arg 
305                 310                 315                 320 


Ser Arg Arg Ser Arg Ser Arg Ser Pro Gly Ser Tyr Lys Gln Arg Glu 
                325                 330                 335     


Thr Arg Lys Arg Ala Gln Arg Asn Pro Gly Glu Glu Gln Ser Arg Arg 
            340                 345                 350         


Asn Asp Ser Arg Ser His Gly Thr Asp Leu Tyr Arg Gly Glu Lys Met 
        355                 360                 365             


Tyr Arg Glu His Pro Gly Gly Thr His Thr Lys Val Thr Gln Arg Glu 
    370                 375                 380                 


<210>  8793
<211>  885
<212>  DNA
<213>  Homosapiens

<400>  8793
aaaaaagaaa aaagatagaa aaaagaaaaa gtttcagaag agcagaaaaa aatacaaagg     60

aagaaaagaa agaaaaacaa gtgttcaggg cataacaaca gtgattctga agagaaggac    120

aagtctaaga agagaaagct tcatgaagaa ctttctagca gtcaccataa ccgggaaaaa    180

gccaaggaaa agcccaggtt cttaaaacac gagagttcta gggaggacag caaatggagc    240

cattctgatt ctgacaaaaa gtccagaacc cataaacata gcccagagaa gagaggctct    300

gaaagaaagg aggggagcag cagaagccac ggcagggagg aaaggagccg gagaagccgg    360

agcagaagtc ctggtagtta caagcaaagg gagacaagga aacgggcaca gcgaaatcct    420

ggtgaagagc aaagcagaag aaatgacagc agaagccatg gcacagactt gtatagagga    480

gaaaaaatgt acagagagca cccaggaggt acacatacta aagtgacaca aagagaatga    540

agcagaagta gagaagaaag actgtatgtg acaattacct gggaataaaa atatctccac    600

ttttttattg aataccttta gcaaggggta aattatgtac tgttgtcttt ctaataaaaa    660

agctcaattt taatttttca tctctagact gtcaattcaa gtacaaaact acatgagtac    720

tataagaatg aattttgcaa atatttgtaa gtaagctatt ttggggctgt ggaaatattt    780

tctgttggta actgtttctt gttccccata ccagataaaa accgcatata actctgtgac    840

attttctttg ttctgaaaca tcattaaaag aatgacagta cattg                    885


<210>  8794
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  8794

Lys Arg Lys Lys Ile Glu Lys Arg Lys Ser Phe Arg Arg Ala Glu Lys 
1               5                   10                  15      


Asn Thr Lys Glu Glu Lys Lys Glu Lys Gln Val Phe Arg Ala 
            20                  25                  30  


<210>  8795
<211>  1817
<212>  DNA
<213>  Homosapiens

<400>  8795
cttgctgctg gaaacgcagt tccggttagg cggctgagtt tgtttacgtt gctaacagat     60

ctagcccctg ctttccctag ttccagttcc aagatgggga aatccttcgc caacttcatg    120

tgcaagaaag actttcatcc tgcctccaaa tccaatatca aaaaagtatg gatggcagaa    180

cagaaaatat catatgataa gaagaaacaa gaagaattga tgcagcaata tcttaaagaa    240

caagaatcat atgataatag attgcttatg ggagatgaac gtgtaaagaa tggccttaat    300

ttcatgtatg aagccccacc aggagctaaa aaaggtactt atcaaagaag aaacagaagg    360

agagaccgaa tacaaatttg aatggcagaa aggagcccca cgagaaaaat atgccaaaga    420

tgacatgaac atcagagatc agccctttgg tattcaggtt cgaaatgtga ggtgcattaa    480

atgtcacaaa tggggtcatg tcaacacaga tcgagaatgt cctttgtttg gtctttctgg    540

aatcaatgca agttcggttc ccactgatgg ctcagatgct gtgttacaaa ttgaaggttt    600

ctgggccatc gatgcacccc tcggagctaa tagcggagat gagaaacagt gggtttgcac    660

tgaaacgaaa tgtactgggg agaaacttga ccgcaaatga tccatcacag gagtatgttg    720

caagtgaggg tgaagaagat ccagaagttg aatttttaaa gtcactaaca accaaacaaa    780

aacagaaact tctcaggaaa ttagatcgac tggagaagaa aaaaaagaaa aaagatagaa    840

aaaagaaaaa gtttcagaag agcagaagta aacacaaaaa acataagtcc tcttcttcct    900

catcttcctc ctcctcctcc tcttcctcta ctgagacttc agaaagcagt agtgagagtg    960

agagtaacaa taaagaaaaa aaaatacaaa ggaagaaaag aaagaaaaac aagtgttcag   1020

ggcataacaa cagtgattct gaagagaagg acaagtctaa gaagagaaag cttcatgaag   1080

aactttctag cagtcaccat aaccgggaaa aagccaagga aaagcccagg ttcttaaaac   1140

acgagagttc tagggaggac agcaaatgga gccattctga ttctgacaaa aagtccagaa   1200

cccataaaca tagcccagag aagagaggct ctgaaagaaa ggaggggagc agcagaagcc   1260

acggcaggga ggaaaggagc cggagaagcc ggagcagaag tcctggtagt tacaagcaaa   1320

gggagacaag gaaacgggca cagcgaaatc ctggtgaaga gcaaagcaga agaaatgaca   1380

gcagaagcca tggcacagac ttgtatagag gagaaaaaat gtacagagag cacccaggag   1440

gtacacatac taaagtgaca caaagagaat gaagcagaag tagagaagaa agactgtatg   1500

tgacaattac ctgggaataa aaatatctcc acttttttat tgaatacctt tagcaagggg   1560

taaattatgt actgttgtct ttctaataaa aaagctcaat tttaattttt catctctaga   1620

ctgtcaattc aagtacaaaa ctacatgagt actataagaa tgaattttgc aaatatttgt   1680

aagtaagcta ttttggggct gtggaaatat tttctgttgg taactgtttc ttgttcccca   1740

taccagataa aaaccgcata taactctgtg acattttctt tgttctgaaa catcattaaa   1800

agaatgacag tacattg                                                  1817


<210>  8796
<211>  324
<212>  PRT
<213>  Homosapiens

<400>  8796

Met Ser Thr Gln Ile Glu Asn Val Leu Cys Leu Val Phe Leu Glu Ser 
1               5                   10                  15      


Met Gln Val Arg Phe Pro Leu Met Ala Gln Met Leu Cys Tyr Lys Leu 
            20                  25                  30          


Lys Val Ser Gly Pro Ser Met His Pro Ser Glu Leu Ile Ala Glu Met 
        35                  40                  45              


Arg Asn Ser Gly Phe Ala Leu Lys Arg Asn Val Leu Gly Arg Asn Leu 
    50                  55                  60                  


Thr Ala Asn Asp Pro Ser Gln Glu Tyr Val Ala Ser Glu Gly Glu Glu 
65                  70                  75                  80  


Asp Pro Glu Val Glu Phe Leu Lys Ser Leu Thr Thr Lys Gln Lys Gln 
                85                  90                  95      


Lys Leu Leu Arg Lys Leu Asp Arg Leu Glu Lys Lys Lys Lys Lys Lys 
            100                 105                 110         


Asp Arg Lys Lys Lys Lys Phe Gln Lys Ser Arg Ser Lys His Lys Lys 
        115                 120                 125             


His Lys Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
    130                 135                 140                 


Thr Glu Thr Ser Glu Ser Ser Ser Glu Ser Glu Ser Asn Asn Lys Glu 
145                 150                 155                 160 


Lys Lys Ile Gln Arg Lys Lys Arg Lys Lys Asn Lys Cys Ser Gly His 
                165                 170                 175     


Asn Asn Ser Asp Ser Glu Glu Lys Asp Lys Ser Lys Lys Arg Lys Leu 
            180                 185                 190         


His Glu Glu Leu Ser Ser Ser His His Asn Arg Glu Lys Ala Lys Glu 
        195                 200                 205             


Lys Pro Arg Phe Leu Lys His Glu Ser Ser Arg Glu Asp Ser Lys Trp 
    210                 215                 220                 


Ser His Ser Asp Ser Asp Lys Lys Ser Arg Thr His Lys His Ser Pro 
225                 230                 235                 240 


Glu Lys Arg Gly Ser Glu Arg Lys Glu Gly Ser Ser Arg Ser His Gly 
                245                 250                 255     


Arg Glu Glu Arg Ser Arg Arg Ser Arg Ser Arg Ser Pro Gly Ser Tyr 
            260                 265                 270         


Lys Gln Arg Glu Thr Arg Lys Arg Ala Gln Arg Asn Pro Gly Glu Glu 
        275                 280                 285             


Gln Ser Arg Arg Asn Asp Ser Arg Ser His Gly Thr Asp Leu Tyr Arg 
    290                 295                 300                 


Gly Glu Lys Met Tyr Arg Glu His Pro Gly Gly Thr His Thr Lys Val 
305                 310                 315                 320 


Thr Gln Arg Glu 
                


<210>  8797
<211>  1789
<212>  DNA
<213>  Homosapiens

<400>  8797
cttgctgctg gaaacgcagt tccggttagg cggctgagtt tgtttacgtt gctaacagat     60

ctagcccctg ctttccctag ttccagttcc aagatgggga aatccttcgc caacttcatg    120

tgcaagaaag actttcatcc tgcctccaaa tccaatatca aaaaagtatg gatggcagaa    180

cagaaaatat catatgataa gaagaaacaa gaagaattga tgcagcaata tcttaaagaa    240

caagaatcat atgataatag attgcttatg ggagatgaac gtgtaaagaa tggccttaat    300

ttcatgtatg aagccccacc aggagctaaa aaaggtactt atcaaagaag aaacagaagg    360

agagaccgaa tacaaatttg aatggcagaa aggagcccca cgagaaaaat atgccaaaga    420

tgacatgaac atcagagatc agccctttgg tattcaggtt cgaaatgtga ggtgcattaa    480

atgtcacaaa tggggtcatg tcaacacaga tcgagaatgt cctttgtttg gtctttctgg    540

aatcaatgca agttcggttc ccactgatgg ctcagggcca tcgatgcacc cctcggagct    600

aatagcggag atgagaaaca gtgggtttgc actgaaacga aatgtactgg ggagaaactt    660

gaccgcaaat gatccatcac aggagtatgt tgcaagtgag ggtgaagaag atccagaagt    720

tgaattttta aagtcactaa caaccaaaca aaaacagaaa cttctcagga aattagatcg    780

actggagaag aaaaaaaaga aaaaagatag aaaaaagaaa aagtttcaga agagcagaag    840

taaacacaaa aaacataagt cctcttcttc ctcatcttcc tcctcctcct cctcttcctc    900

tactgagact tcagaaagca gtagtgagag tgagagtaac aataaagaaa aaaaaataca    960

aaggaagaaa agaaagaaaa acaagtgttc agggcataac aacagtgatt ctgaagagaa   1020

ggacaagtct aagaagagaa agcttcatga agaactttct agcagtcacc ataaccggga   1080

aaaagccaag gaaaagccca ggttcttaaa acacgagagt tctagggagg acagcaaatg   1140

gagccattct gattctgaca aaaagtccag aacccataaa catagcccag agaagagagg   1200

ctctgaaaga aaggagggga gcagcagaag ccacggcagg gaggaaagga gccggagaag   1260

ccggagcaga agtcctggta gttacaagca aagggagaca aggaaacggg cacagcgaaa   1320

tcctggtgaa gagcaaagca gaagaaatga cagcagaagc catggcacag acttgtatag   1380

aggagaaaaa atgtacagag agcacccagg aggtacacat actaaagtga cacaaagaga   1440

atgaagcaga agtagagaag aaagactgta tgtgacaatt acctgggaat aaaaatatct   1500

ccactttttt attgaatacc tttagcaagg ggtaaattat gtactgttgt ctttctaata   1560

aaaaagctca attttaattt ttcatctcta gactgtcaat tcaagtacaa aactacatga   1620

gtactataag aatgaatttt gcaaatattt gtaagtaagc tattttgggg ctgtggaaat   1680

attttctgtt ggtaactgtt tcttgttccc cataccagat aaaaaccgca tataactctg   1740

tgacattttc tttgttctga aacatcatta aaagaatgac agtacattg               1789


<210>  8798
<211>  384
<212>  PRT
<213>  Homosapiens

<400>  8798

Met Ala Leu Ile Ser Cys Met Lys Pro His Gln Glu Leu Lys Lys Val 
1               5                   10                  15      


Leu Ile Lys Glu Glu Thr Glu Gly Glu Thr Glu Tyr Lys Phe Glu Trp 
            20                  25                  30          


Gln Lys Gly Ala Pro Arg Glu Lys Tyr Ala Lys Asp Asp Met Asn Ile 
        35                  40                  45              


Arg Asp Gln Pro Phe Gly Ile Gln Val Arg Asn Val Arg Cys Ile Lys 
    50                  55                  60                  


Cys His Lys Trp Gly His Val Asn Thr Asp Arg Glu Cys Pro Leu Phe 
65                  70                  75                  80  


Gly Leu Ser Gly Ile Asn Ala Ser Ser Val Pro Thr Asp Gly Ser Gly 
                85                  90                  95      


Pro Ser Met His Pro Ser Glu Leu Ile Ala Glu Met Arg Asn Ser Gly 
            100                 105                 110         


Phe Ala Leu Lys Arg Asn Val Leu Gly Arg Asn Leu Thr Ala Asn Asp 
        115                 120                 125             


Pro Ser Gln Glu Tyr Val Ala Ser Glu Gly Glu Glu Asp Pro Glu Val 
    130                 135                 140                 


Glu Phe Leu Lys Ser Leu Thr Thr Lys Gln Lys Gln Lys Leu Leu Arg 
145                 150                 155                 160 


Lys Leu Asp Arg Leu Glu Lys Lys Lys Lys Lys Lys Asp Arg Lys Lys 
                165                 170                 175     


Lys Lys Phe Gln Lys Ser Arg Ser Lys His Lys Lys His Lys Ser Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Glu Thr Ser 
        195                 200                 205             


Glu Ser Ser Ser Glu Ser Glu Ser Asn Asn Lys Glu Lys Lys Ile Gln 
    210                 215                 220                 


Arg Lys Lys Arg Lys Lys Asn Lys Cys Ser Gly His Asn Asn Ser Asp 
225                 230                 235                 240 


Ser Glu Glu Lys Asp Lys Ser Lys Lys Arg Lys Leu His Glu Glu Leu 
                245                 250                 255     


Ser Ser Ser His His Asn Arg Glu Lys Ala Lys Glu Lys Pro Arg Phe 
            260                 265                 270         


Leu Lys His Glu Ser Ser Arg Glu Asp Ser Lys Trp Ser His Ser Asp 
        275                 280                 285             


Ser Asp Lys Lys Ser Arg Thr His Lys His Ser Pro Glu Lys Arg Gly 
    290                 295                 300                 


Ser Glu Arg Lys Glu Gly Ser Ser Arg Ser His Gly Arg Glu Glu Arg 
305                 310                 315                 320 


Ser Arg Arg Ser Arg Ser Arg Ser Pro Gly Ser Tyr Lys Gln Arg Glu 
                325                 330                 335     


Thr Arg Lys Arg Ala Gln Arg Asn Pro Gly Glu Glu Gln Ser Arg Arg 
            340                 345                 350         


Asn Asp Ser Arg Ser His Gly Thr Asp Leu Tyr Arg Gly Glu Lys Met 
        355                 360                 365             


Tyr Arg Glu His Pro Gly Gly Thr His Thr Lys Val Thr Gln Arg Glu 
    370                 375                 380                 


<210>  8799
<211>  1583
<212>  DNA
<213>  Homosapiens

<400>  8799
cttgctgctg gaaacgcagt tccggttagg cggctgagtt tgtttacgtt gctaacagat     60

ctagcccctg ctttccctag ttccagttcc aagatgggga aatccttcgc caacttcatg    120

tgcaagaaag actttcatcc tgcctccaaa tccaatatca aaaaagtatg gatggcagaa    180

cagaaaatat catatgataa gaagaaacaa gaagaattga tgcagcaata tcttaaagaa    240

caagaatcat atgataatag attgcttatg ggagatgaac gtgtaaagaa tggccttaat    300

ttcatgtatg aagccccacc aggagctaaa aaaggtactt atcaaagaag aaacagaagg    360

agagaccgaa tacaaatttg aatggcagaa aggagcccca cgagaaaaat atgccaaaga    420

tgacatgaac atcagagatc agccctttgg tattcaggtt cgaaatgtga ggtgcattaa    480

atgtcacaaa tggggtcatg tcaacacaga tcgagaatgt cctttgtttg gtctttctgg    540

aatcaatgca agttcggttc ccactgatgg ctcagggcca tcgatgcacc cctcggagct    600

aatagcggag atgagaaaca gtgggtttgc actgaaacga aatgtactgg ggagaaactt    660

gaccgcaaat gatccatcac aggagtatgt tgcaagtgag ggtgaagaag atccagaagt    720

tgaattttta aagtcactaa caaccaaaca aaaacagaaa cttctcagga aattagatcg    780

actggagaag aaaaaaaaga aaaaagatag aaaaaagaaa aagtttcaga agagcagaag    840

taaacacaaa aaacataagt cctcttcttc ctcatcttcc tcctcctcct cctcttcctc    900

tactgagact tcagaaagca gtagtgagag tgagagtaac aataaagaaa aaaaaataca    960

aaggaagaaa agaaagaaaa acaagtgttc agggcataac aacagtgatt ctgaagagaa   1020

ggacaagtct aagaagagaa agcttcatga agaactttct agcagtcacc ataaccggga   1080

aaaagccaag gaaaagccca ggttcttaaa acacgagagt tctagggagg acagcaaatg   1140

gagccattct gattctgaca aaaagtccag aacccataaa catagcccag agaagagagg   1200

ctctgaaaga aaggagggga gcagcagaag ccacggcagg gaggaaagga gccggagaag   1260

ccggagcaga agtcctggta gttacaagca aagggagaca aggaaacggg cacagcgaaa   1320

tcctggtgaa gagcaaagca gaagaaatga cagcagaagc catggcacag acttgtatag   1380

aggagaaaaa atgtacagag agcacccagg aggtacacat actaaagtga cacaaagaga   1440

atgaagcaga agtagagaag aaagactgta tgtgacaatt acctgggaat aaaaatatct   1500

ccactttttt attgaatacc tttagcaagg ggtaaattat gtactgttgt ctttctaata   1560

aaaaagctca attttaattt ttc                                           1583


<210>  8800
<211>  384
<212>  PRT
<213>  Homosapiens

<400>  8800

Met Ala Leu Ile Ser Cys Met Lys Pro His Gln Glu Leu Lys Lys Val 
1               5                   10                  15      


Leu Ile Lys Glu Glu Thr Glu Gly Glu Thr Glu Tyr Lys Phe Glu Trp 
            20                  25                  30          


Gln Lys Gly Ala Pro Arg Glu Lys Tyr Ala Lys Asp Asp Met Asn Ile 
        35                  40                  45              


Arg Asp Gln Pro Phe Gly Ile Gln Val Arg Asn Val Arg Cys Ile Lys 
    50                  55                  60                  


Cys His Lys Trp Gly His Val Asn Thr Asp Arg Glu Cys Pro Leu Phe 
65                  70                  75                  80  


Gly Leu Ser Gly Ile Asn Ala Ser Ser Val Pro Thr Asp Gly Ser Gly 
                85                  90                  95      


Pro Ser Met His Pro Ser Glu Leu Ile Ala Glu Met Arg Asn Ser Gly 
            100                 105                 110         


Phe Ala Leu Lys Arg Asn Val Leu Gly Arg Asn Leu Thr Ala Asn Asp 
        115                 120                 125             


Pro Ser Gln Glu Tyr Val Ala Ser Glu Gly Glu Glu Asp Pro Glu Val 
    130                 135                 140                 


Glu Phe Leu Lys Ser Leu Thr Thr Lys Gln Lys Gln Lys Leu Leu Arg 
145                 150                 155                 160 


Lys Leu Asp Arg Leu Glu Lys Lys Lys Lys Lys Lys Asp Arg Lys Lys 
                165                 170                 175     


Lys Lys Phe Gln Lys Ser Arg Ser Lys His Lys Lys His Lys Ser Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Glu Thr Ser 
        195                 200                 205             


Glu Ser Ser Ser Glu Ser Glu Ser Asn Asn Lys Glu Lys Lys Ile Gln 
    210                 215                 220                 


Arg Lys Lys Arg Lys Lys Asn Lys Cys Ser Gly His Asn Asn Ser Asp 
225                 230                 235                 240 


Ser Glu Glu Lys Asp Lys Ser Lys Lys Arg Lys Leu His Glu Glu Leu 
                245                 250                 255     


Ser Ser Ser His His Asn Arg Glu Lys Ala Lys Glu Lys Pro Arg Phe 
            260                 265                 270         


Leu Lys His Glu Ser Ser Arg Glu Asp Ser Lys Trp Ser His Ser Asp 
        275                 280                 285             


Ser Asp Lys Lys Ser Arg Thr His Lys His Ser Pro Glu Lys Arg Gly 
    290                 295                 300                 


Ser Glu Arg Lys Glu Gly Ser Ser Arg Ser His Gly Arg Glu Glu Arg 
305                 310                 315                 320 


Ser Arg Arg Ser Arg Ser Arg Ser Pro Gly Ser Tyr Lys Gln Arg Glu 
                325                 330                 335     


Thr Arg Lys Arg Ala Gln Arg Asn Pro Gly Glu Glu Gln Ser Arg Arg 
            340                 345                 350         


Asn Asp Ser Arg Ser His Gly Thr Asp Leu Tyr Arg Gly Glu Lys Met 
        355                 360                 365             


Tyr Arg Glu His Pro Gly Gly Thr His Thr Lys Val Thr Gln Arg Glu 
    370                 375                 380                 


<210>  8801
<211>  671
<212>  DNA
<213>  Homosapiens

<400>  8801
aaaaaagaaa aaagatagaa aaaagaaaaa gtttcagaag agcagaaaaa aatacaaagg     60

aagaaaagaa agaaaaacaa gtgttcaggg cataacaaca gtgattctga agagaaggac    120

aagtctaaga agagaaagct tcatgaagaa ctttctagca gtcaccataa ccgggaaaaa    180

gccaaggaaa agcccaggtt cttaaaacac gagagttcta gggaggacag caaatggagc    240

cattctgatt ctgacaaaaa gtccagaacc cataaacata gcccagagaa gagaggctct    300

gaaagaaagg aggggagcag cagaagccac ggcagggagg aaaggagccg gagaagccgg    360

agcagaagtc ctggtagtta caagcaaagg gagacaagga aacgggcaca gcgaaatcct    420

ggtgaagagc aaagcagaag aaatgacagc agaagccatg gcacagactt gtatagagga    480

gaaaaaatgt acagagagca cccaggaggt acacatacta aagtgacaca aagagaatga    540

agcagaagta gagaagaaag actgtatgtg acaattacct gggaataaaa atatctccac    600

ttttttattg aataccttta gcaaggggta aattatgtac tgttgtcttt ctaataaaaa    660

agctcaattt t                                                         671


<210>  8802
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  8802

Lys Arg Lys Lys Ile Glu Lys Arg Lys Ser Phe Arg Arg Ala Glu Lys 
1               5                   10                  15      


Asn Thr Lys Glu Glu Lys Lys Glu Lys Gln Val Phe Arg Ala 
            20                  25                  30  


<210>  8803
<211>  1341
<212>  DNA
<213>  Homosapiens

<400>  8803
cttgctgctg gaaacgcagt tccggttagg cggctgagtt tgtttacgtt gctaacagat     60

ctagcccctg ctttccctag ttccagttcc aagatgggga aatccttcgc caacttcatg    120

tgcaagaaag actttcatcc tgcctccaaa tccaatatca aaaaagtatg gatggcagaa    180

cagaaaatat catatgataa gaagaaacaa gaagaattga tgcagcaata tcttaaagaa    240

caagaatcat atgataatag attgcttatg ggagatgaac gtgtaaagaa tggccttaat    300

ttcatgtatg aagccccacc aggagctaaa aaaggtactt atcaaagaag aaacagaagg    360

agagaccgaa tacaaatttg aatggcagaa aggagcccca cgagaaaaat atgccaaaga    420

tgacatgaac atcagagatc agccctttgg tattcaggtt cgaaatgtga ggtgcattaa    480

atgtcacaaa tggggtcatg tcaacacaga tcgagaatgt cctttgtttg gtctttctgg    540

aatcaatgca agttcggttc ccactgatgg ctcagggcca tcgatgcacc cctcggagct    600

aatagcggag atgagaaaca gtgggtttgc actgaaacga aatgtactgg ggagaaactt    660

gaccgcaaat gatccatcac aggagtatgt tgcaagtgag ggtgaagaag atccagaagt    720

tgaattttta aagtcactaa caaccaaaca aaaacagaaa cttctcagga aattagatcg    780

actggagaag aaaaaaaaga aaaaagatag aaaaaagaaa aagtttcaga agagcagaag    840

taaacacaaa aaacataagt cctcttcttc ctcatcttcc tcctcctcct cctcttcctc    900

tactgagact tcagaaagca gtagtgagag tgagagtaac aataaagaaa aaaaaataca    960

aaggaagaaa agaaagaaaa acaagtgttc agggcataac aacagtgatt ctgaagagaa   1020

ggacaagtct aagaagagaa agcttcatga agaactttct agcagtcacc ataaccggga   1080

aaaagccaag gaaaagccca ggttcttaaa acacgagagt tctagggagg acagcaaatg   1140

gagccattct gattctgaca aaaagtccag aacccataaa catagcccag agaagagagg   1200

ctctgaaaga aaggagggga gcagcagaag ccacggcagg gaggaaagga gccggagaag   1260

ccggagcaga agtcctggta gttacaagca aagggagaca aggaaacggg cacagcgaaa   1320

tcctggtgaa gagcaaagca g                                             1341


<210>  8804
<211>  349
<212>  PRT
<213>  Homosapiens

<400>  8804

Met Ala Leu Ile Ser Cys Met Lys Pro His Gln Glu Leu Lys Lys Val 
1               5                   10                  15      


Leu Ile Lys Glu Glu Thr Glu Gly Glu Thr Glu Tyr Lys Phe Glu Trp 
            20                  25                  30          


Gln Lys Gly Ala Pro Arg Glu Lys Tyr Ala Lys Asp Asp Met Asn Ile 
        35                  40                  45              


Arg Asp Gln Pro Phe Gly Ile Gln Val Arg Asn Val Arg Cys Ile Lys 
    50                  55                  60                  


Cys His Lys Trp Gly His Val Asn Thr Asp Arg Glu Cys Pro Leu Phe 
65                  70                  75                  80  


Gly Leu Ser Gly Ile Asn Ala Ser Ser Val Pro Thr Asp Gly Ser Gly 
                85                  90                  95      


Pro Ser Met His Pro Ser Glu Leu Ile Ala Glu Met Arg Asn Ser Gly 
            100                 105                 110         


Phe Ala Leu Lys Arg Asn Val Leu Gly Arg Asn Leu Thr Ala Asn Asp 
        115                 120                 125             


Pro Ser Gln Glu Tyr Val Ala Ser Glu Gly Glu Glu Asp Pro Glu Val 
    130                 135                 140                 


Glu Phe Leu Lys Ser Leu Thr Thr Lys Gln Lys Gln Lys Leu Leu Arg 
145                 150                 155                 160 


Lys Leu Asp Arg Leu Glu Lys Lys Lys Lys Lys Lys Asp Arg Lys Lys 
                165                 170                 175     


Lys Lys Phe Gln Lys Ser Arg Ser Lys His Lys Lys His Lys Ser Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Glu Thr Ser 
        195                 200                 205             


Glu Ser Ser Ser Glu Ser Glu Ser Asn Asn Lys Glu Lys Lys Ile Gln 
    210                 215                 220                 


Arg Lys Lys Arg Lys Lys Asn Lys Cys Ser Gly His Asn Asn Ser Asp 
225                 230                 235                 240 


Ser Glu Glu Lys Asp Lys Ser Lys Lys Arg Lys Leu His Glu Glu Leu 
                245                 250                 255     


Ser Ser Ser His His Asn Arg Glu Lys Ala Lys Glu Lys Pro Arg Phe 
            260                 265                 270         


Leu Lys His Glu Ser Ser Arg Glu Asp Ser Lys Trp Ser His Ser Asp 
        275                 280                 285             


Ser Asp Lys Lys Ser Arg Thr His Lys His Ser Pro Glu Lys Arg Gly 
    290                 295                 300                 


Ser Glu Arg Lys Glu Gly Ser Ser Arg Ser His Gly Arg Glu Glu Arg 
305                 310                 315                 320 


Ser Arg Arg Ser Arg Ser Arg Ser Pro Gly Ser Tyr Lys Gln Arg Glu 
                325                 330                 335     


Thr Arg Lys Arg Ala Gln Arg Asn Pro Gly Glu Glu Gln 
            340                 345                 


<210>  8805
<211>  749
<212>  DNA
<213>  Homosapiens

<400>  8805
cttgctgctg gaaacgcagt tccggttagg cggctgagtt tgtttacgtt gctaacagat     60

ctagcccctg ctttccctag ttccagttcc aagatgggga aatccttcgc caacttcatg    120

tgcaagaaag actttcatcc tgcctccaaa tccaatatca aaaaagtatg gatggcagaa    180

cagaaaatat catatgataa gaagaaacaa gaagaattga tgcagcaata tcttaaagaa    240

caagaatcat atgataatag attgcttatg ggagatgaac gtgtaaagaa tggccttaat    300

ttcatgtatg aagccccacc aggagctaaa aaaggtactt atcaaagaag aaacagaagg    360

agagaccgaa tacaaatttg aatggcagaa aggagcccca cgagaaaaat atgccaaaga    420

tgacatgaac atcagagatc agccctttgg tattcaggtt cgaaatgtga ggtgcattaa    480

atgtcacaaa tggggtcatg tcaacacaga tcgagaatgt cctttgtttg gtctttctgg    540

aatcaatgca agttcggttc ccactgatgg ctcagggcca tcgatgcacc cctcggagct    600

aatagcggag atgagaaaca gtgggtttgc actgaaacga aatgtactgg ggagaaactt    660

gaccgcaaat gatccatcac aggagtatgt tgcaagtgag ggtgaagaag atccagaagt    720

tgaattttta aagtcactaa caaccaaac                                      749


<210>  8806
<211>  152
<212>  PRT
<213>  Homosapiens

<400>  8806

Met Ala Leu Ile Ser Cys Met Lys Pro His Gln Glu Leu Lys Lys Val 
1               5                   10                  15      


Leu Ile Lys Glu Glu Thr Glu Gly Glu Thr Glu Tyr Lys Phe Glu Trp 
            20                  25                  30          


Gln Lys Gly Ala Pro Arg Glu Lys Tyr Ala Lys Asp Asp Met Asn Ile 
        35                  40                  45              


Arg Asp Gln Pro Phe Gly Ile Gln Val Arg Asn Val Arg Cys Ile Lys 
    50                  55                  60                  


Cys His Lys Trp Gly His Val Asn Thr Asp Arg Glu Cys Pro Leu Phe 
65                  70                  75                  80  


Gly Leu Ser Gly Ile Asn Ala Ser Ser Val Pro Thr Asp Gly Ser Gly 
                85                  90                  95      


Pro Ser Met His Pro Ser Glu Leu Ile Ala Glu Met Arg Asn Ser Gly 
            100                 105                 110         


Phe Ala Leu Lys Arg Asn Val Leu Gly Arg Asn Leu Thr Ala Asn Asp 
        115                 120                 125             


Pro Ser Gln Glu Tyr Val Ala Ser Glu Gly Glu Glu Asp Pro Glu Val 
    130                 135                 140                 


Glu Phe Leu Lys Ser Leu Thr Thr 
145                 150         


<210>  8807
<211>  808
<212>  DNA
<213>  Homosapiens

<400>  8807
gctgctggaa acgcagttcc ggttaggcgg ctgagtttgt ttacgttgct aacagatcta     60

gcccctgctt tccctagttc cagttccaag atggggaaat ccttcgccaa cttcatgtgc    120

aagaaagact ttcatcctgc ctccaaatcc aatatcaaaa aagtatggat ggcagaacag    180

aaaatatcat atgataagaa gaaacaagaa gaattgatgc agcaatatct taaagaacaa    240

gaatcatatg ataatagatt gcttatggga gatgaacgtg taaagaatgg ccttaatttc    300

atgtatgaag ccccaccagg agctaaaaaa ggtacttatc aaagaagaaa cagaaggaga    360

gaccgaatac aaatttgaat ggcagaaagg agccccacga gaaaaatatg ccaaagatga    420

catgaacatc agagatcagc cctttggtat tcaggttcga aatgtgaggt gcattaaatg    480

tcacaaatgg ggtcatgtca acacagatcg agaatgtcct ttgtttggtc tttctggaat    540

caatgcaagt tcggttccca ctgatggctc aggtaggcac tagacatgat ttgtttcggg    600

agaggacaaa caaggaaaga taaaacaaca tttttcttta ctctttctgg gtattgtttt    660

atttgggttt gtgtgtgggg cttgtttgtt tgtttttgac taagaccatt cccaaaatat    720

gattaatggg aaactctgat catatatgtt gaattaaaat gctgtgtaat aggattaagt    780

ttaatttttc cagccaaagg ccctatga                                       808


<210>  8808
<211>  98
<212>  PRT
<213>  Homosapiens

<400>  8808

Met Ala Leu Ile Ser Cys Met Lys Pro His Gln Glu Leu Lys Lys Val 
1               5                   10                  15      


Leu Ile Lys Glu Glu Thr Glu Gly Glu Thr Glu Tyr Lys Phe Glu Trp 
            20                  25                  30          


Gln Lys Gly Ala Pro Arg Glu Lys Tyr Ala Lys Asp Asp Met Asn Ile 
        35                  40                  45              


Arg Asp Gln Pro Phe Gly Ile Gln Val Arg Asn Val Arg Cys Ile Lys 
    50                  55                  60                  


Cys His Lys Trp Gly His Val Asn Thr Asp Arg Glu Cys Pro Leu Phe 
65                  70                  75                  80  


Gly Leu Ser Gly Ile Asn Ala Ser Ser Val Pro Thr Asp Gly Ser Gly 
                85                  90                  95      


Arg His 
        


<210>  8809
<211>  1167
<212>  DNA
<213>  Homosapiens

<400>  8809
gacagcttcc ggcaactgat gcctccactg gccactcctc cctccgtcca cctgtcactt     60

cgggtagctg ggaggccagt taaaaaaaat ggaacctttt tcctgtgaca ctttcgtggc    120

attacctcca gcaacagtcg ataacaggat tatttttgga aaaaattcag atagactcta    180

tgatgaagta caagaggtgg tttattttcc tgctgtagtt catgataacc tgggagaacg    240

tcttaagtgt acatatatag aaattgatca agttcctgaa acatatgctg ttgtcctgag    300

tcgcccagcg tggttgtggg gggcagaaat gggagccaat gagcatggag tttgcattgg    360

gaatgaagct gtatggggaa gagaagaagt ttgtgatgaa gaagcactat taggaatgga    420

ccttgtcaga cttggccttg aaagagctga tacagctgaa aaagccctca atgtcattgt    480

tgacttacta gaaaaatatg gccagggtgg aaattgcaca gagggtagaa tggtatttag    540

ctatcacaac agtttcctga tagctgatag gaatgaagcc tggattctgg agactgcagg    600

gaagtactgg gcagcagaaa aagtacaaga gggagttcgt aatatttcta atcaactttc    660

cataacaacc aagattgccc gggaacaccc agacatgaga aactatgcta agcggaaagg    720

ttggtgggat ggtaaaaagg agtttgattt tgctgcagca tattcctatc ttgacacagc    780

caagatgatg acttcatcag gcagatactg tgagggctac aagcttctaa ataagcacaa    840

aggaaatata acttttgaaa caatgatgga aattcttcga gataaaccaa gtggcattaa    900

tatggaggga gaattcctga ccactgcaag catggtttct attttacctc aagactccag    960

ccttccttgc attcacttct ttacagggac tcctgatcct gagagatctg tttttaagcc   1020

tttcatattt gtgccacata tttcacaact attggatacc agttcaccaa catttgaact   1080

tgaagatcta gttaaaaaga aatcacattt taagcctgac agaagacacc cactctacca   1140

aaaacatcaa caggcattgg aagtagt                                       1167


<210>  8810
<211>  358
<212>  PRT
<213>  Homosapiens

<400>  8810

Met Glu Pro Phe Ser Cys Asp Thr Phe Val Ala Leu Pro Pro Ala Thr 
1               5                   10                  15      


Val Asp Asn Arg Ile Ile Phe Gly Lys Asn Ser Asp Arg Leu Tyr Asp 
            20                  25                  30          


Glu Val Gln Glu Val Val Tyr Phe Pro Ala Val Val His Asp Asn Leu 
        35                  40                  45              


Gly Glu Arg Leu Lys Cys Thr Tyr Ile Glu Ile Asp Gln Val Pro Glu 
    50                  55                  60                  


Thr Tyr Ala Val Val Leu Ser Arg Pro Ala Trp Leu Trp Gly Ala Glu 
65                  70                  75                  80  


Met Gly Ala Asn Glu His Gly Val Cys Ile Gly Asn Glu Ala Val Trp 
                85                  90                  95      


Gly Arg Glu Glu Val Cys Asp Glu Glu Ala Leu Leu Gly Met Asp Leu 
            100                 105                 110         


Val Arg Leu Gly Leu Glu Arg Ala Asp Thr Ala Glu Lys Ala Leu Asn 
        115                 120                 125             


Val Ile Val Asp Leu Leu Glu Lys Tyr Gly Gln Gly Gly Asn Cys Thr 
    130                 135                 140                 


Glu Gly Arg Met Val Phe Ser Tyr His Asn Ser Phe Leu Ile Ala Asp 
145                 150                 155                 160 


Arg Asn Glu Ala Trp Ile Leu Glu Thr Ala Gly Lys Tyr Trp Ala Ala 
                165                 170                 175     


Glu Lys Val Gln Glu Gly Val Arg Asn Ile Ser Asn Gln Leu Ser Ile 
            180                 185                 190         


Thr Thr Lys Ile Ala Arg Glu His Pro Asp Met Arg Asn Tyr Ala Lys 
        195                 200                 205             


Arg Lys Gly Trp Trp Asp Gly Lys Lys Glu Phe Asp Phe Ala Ala Ala 
    210                 215                 220                 


Tyr Ser Tyr Leu Asp Thr Ala Lys Met Met Thr Ser Ser Gly Arg Tyr 
225                 230                 235                 240 


Cys Glu Gly Tyr Lys Leu Leu Asn Lys His Lys Gly Asn Ile Thr Phe 
                245                 250                 255     


Glu Thr Met Met Glu Ile Leu Arg Asp Lys Pro Ser Gly Ile Asn Met 
            260                 265                 270         


Glu Gly Glu Phe Leu Thr Thr Ala Ser Met Val Ser Ile Leu Pro Gln 
        275                 280                 285             


Asp Ser Ser Leu Pro Cys Ile His Phe Phe Thr Gly Thr Pro Asp Pro 
    290                 295                 300                 


Glu Arg Ser Val Phe Lys Pro Phe Ile Phe Val Pro His Ile Ser Gln 
305                 310                 315                 320 


Leu Leu Asp Thr Ser Ser Pro Thr Phe Glu Leu Glu Asp Leu Val Lys 
                325                 330                 335     


Lys Lys Ser His Phe Lys Pro Asp Arg Arg His Pro Leu Tyr Gln Lys 
            340                 345                 350         


His Gln Gln Ala Leu Glu 
        355             


<210>  8811
<211>  2467
<212>  DNA
<213>  Homosapiens

<400>  8811
gacagcttcc ggcaactgat gcctccactg gccactcctc cctccgtcca cctgtcactt     60

cgggtagctg ggaggccagt taaaaaaaat ggaacctttt tcctgtgaca ctttcgtggc    120

attacctcca gcaacagtcg ataacaggat tatttttgga aaaaattcag atagactcta    180

tgatgaagta caagaggtgg tttattttcc tgctgtagtt catgataacc tgggagaacg    240

tcttaagtgt acatatatag aaattgatca agttcctgaa acatatgctg ttgtcctgag    300

tcgcccagcg tggttgtggg gggcagaaat gggagccaat gagcatggag tttgcattgg    360

gaatgaagct gtatggggaa gagaagaagt ttgtgatgaa gaagcactat taggaatgga    420

ccttgtcaga cttggccttg aaagagctga tacagctgaa aaagccctca atgtcattgt    480

tgacttacta gaaaaatatg gccagggtgg aaattgcaca gagggtagaa tggtatttag    540

ctatcacaac agtttcctga tagctgatag gaatgaagcc tggattctgg agactgcagg    600

gaagtactgg gcagcagaaa aagtacaaga gggagttcgt aatatttcta atcaactttc    660

cataacaacc aagattgccc gggaacaccc agacatgaga aactatgcta agcggaaagg    720

ttggtgggat ggtaaaaagg agtttgattt tgctgcagca tattcctatc ttgacacagc    780

caagatgatg acttcatcag gcagatactg tgagggctac aagcttctaa ataagcacaa    840

aggaaatata acttttgaaa caatgatgga aattcttcga gataaaccaa gtggcattaa    900

tatggaggga gaattcctga ccactgcaag catggtttct attttacctc aagactccag    960

ccttccttgc attcacttct ttacagggac tcctgatcct gagagatctg tttttaagcc   1020

tttcatattt gtgccacata tttcacaact attggatacc agttcaccaa catttgaact   1080

tgaagatcta gttaaaaaga aatcacattt taagcctgac agaagacacc cactctacca   1140

aaaacatcaa caggcattgg aagtagtaaa taataatgag gaaaaagcca aaataatgtt   1200

ggacaacatg aggaaactgg agaaagaact attcagagag atggaatcaa tccttcaaaa   1260

caagcatctt gatgtggaga aaattgttaa tctctttcct cagtgtacaa aagatgaaat   1320

tcaaatttat cagtcaaatt tatcagtcaa agttagttct tagtgatcat atggtcagct   1380

aatattagtt cttagtgatc agtggtcagt aatcttcaaa gtcagaatct atcaccttgg   1440

taaattatat aaacctaact tgagcagatc tgattattct tggatagtat tcaagtggta   1500

tcttgactat taaactacgt atagtgttgc tgaaatagaa agaaaacagc attggaattg   1560

gattcatgta tcgtgggata caggtgttat ttcaggtgat gtacttgcat tattttcttt   1620

agccatagta actttttgtc acaataacta agtattcaat tatatataaa gagtgaaaca   1680

ttaaaatgac gcatggattt atatttatta taattatgta gtaccctcaa atcattttgt   1740

cagttacatc aagaaagcag atttttcttt agtcatgaaa aatatctcaa gtggtaagtt   1800

gtttgtgctt taggcaaaca ttaaccagct ctaacaagaa aaatgtctag atttacacat   1860

tgtcaataca gtatattagt tctgcaaatg cacttttgtt aaactcaaac atgctctttg   1920

tcaagacttg gctaaccagt gagcttgtag ctctgattat ctagcatttt tagggtcatt   1980

ctccttaata ggcttttatg ttaataagat atatttttag aagagcttgt ttgggagatt   2040

agagaataag ataaaagaac caaaacctta ggatatactg tttctgggtc tgaaatctct   2100

ctcattgttt acttctgttc actcagtgaa aacagaaaca agaatgaggt agtggcaatg   2160

aaatagaatt attagtatat tatgaacatt ataacatttt gaacactata atgcattata   2220

tattatgaac ttttatgaac tttatacatg agtaatagct tcctaaagtt tataaaacat   2280

tgtttaggtt acataaagat taccaagtaa gactcaaaat tgcaaatata aacaaaagaa   2340

aaatccaact gaaaataaca ctaagtattt ttgagttcct agaatgtcca ttttggtatt   2400

tggttacatt atcatattta ctagtcacta tcagcacaat taggttaata aagaagtggg   2460

tcattat                                                             2467


<210>  8812
<211>  424
<212>  PRT
<213>  Homosapiens

<400>  8812

Met Glu Pro Phe Ser Cys Asp Thr Phe Val Ala Leu Pro Pro Ala Thr 
1               5                   10                  15      


Val Asp Asn Arg Ile Ile Phe Gly Lys Asn Ser Asp Arg Leu Tyr Asp 
            20                  25                  30          


Glu Val Gln Glu Val Val Tyr Phe Pro Ala Val Val His Asp Asn Leu 
        35                  40                  45              


Gly Glu Arg Leu Lys Cys Thr Tyr Ile Glu Ile Asp Gln Val Pro Glu 
    50                  55                  60                  


Thr Tyr Ala Val Val Leu Ser Arg Pro Ala Trp Leu Trp Gly Ala Glu 
65                  70                  75                  80  


Met Gly Ala Asn Glu His Gly Val Cys Ile Gly Asn Glu Ala Val Trp 
                85                  90                  95      


Gly Arg Glu Glu Val Cys Asp Glu Glu Ala Leu Leu Gly Met Asp Leu 
            100                 105                 110         


Val Arg Leu Gly Leu Glu Arg Ala Asp Thr Ala Glu Lys Ala Leu Asn 
        115                 120                 125             


Val Ile Val Asp Leu Leu Glu Lys Tyr Gly Gln Gly Gly Asn Cys Thr 
    130                 135                 140                 


Glu Gly Arg Met Val Phe Ser Tyr His Asn Ser Phe Leu Ile Ala Asp 
145                 150                 155                 160 


Arg Asn Glu Ala Trp Ile Leu Glu Thr Ala Gly Lys Tyr Trp Ala Ala 
                165                 170                 175     


Glu Lys Val Gln Glu Gly Val Arg Asn Ile Ser Asn Gln Leu Ser Ile 
            180                 185                 190         


Thr Thr Lys Ile Ala Arg Glu His Pro Asp Met Arg Asn Tyr Ala Lys 
        195                 200                 205             


Arg Lys Gly Trp Trp Asp Gly Lys Lys Glu Phe Asp Phe Ala Ala Ala 
    210                 215                 220                 


Tyr Ser Tyr Leu Asp Thr Ala Lys Met Met Thr Ser Ser Gly Arg Tyr 
225                 230                 235                 240 


Cys Glu Gly Tyr Lys Leu Leu Asn Lys His Lys Gly Asn Ile Thr Phe 
                245                 250                 255     


Glu Thr Met Met Glu Ile Leu Arg Asp Lys Pro Ser Gly Ile Asn Met 
            260                 265                 270         


Glu Gly Glu Phe Leu Thr Thr Ala Ser Met Val Ser Ile Leu Pro Gln 
        275                 280                 285             


Asp Ser Ser Leu Pro Cys Ile His Phe Phe Thr Gly Thr Pro Asp Pro 
    290                 295                 300                 


Glu Arg Ser Val Phe Lys Pro Phe Ile Phe Val Pro His Ile Ser Gln 
305                 310                 315                 320 


Leu Leu Asp Thr Ser Ser Pro Thr Phe Glu Leu Glu Asp Leu Val Lys 
                325                 330                 335     


Lys Lys Ser His Phe Lys Pro Asp Arg Arg His Pro Leu Tyr Gln Lys 
            340                 345                 350         


His Gln Gln Ala Leu Glu Val Val Asn Asn Asn Glu Glu Lys Ala Lys 
        355                 360                 365             


Ile Met Leu Asp Asn Met Arg Lys Leu Glu Lys Glu Leu Phe Arg Glu 
    370                 375                 380                 


Met Glu Ser Ile Leu Gln Asn Lys His Leu Asp Val Glu Lys Ile Val 
385                 390                 395                 400 


Asn Leu Phe Pro Gln Cys Thr Lys Asp Glu Ile Gln Ile Tyr Gln Ser 
                405                 410                 415     


Asn Leu Ser Val Lys Val Ser Ser 
            420                 


<210>  8813
<211>  3505
<212>  DNA
<213>  Homosapiens

<400>  8813
gacagcttcc ggcaactgat gcctccactg gccactcctc cctccgtcca cctgtcactt     60

cgggtagctg ggaggccagt taaaaaaaat ggaacctttt tcctgtgaca ctttcgtggc    120

attacctcca gcaacagtcg ataacaggat tatttttgga aaaaattcag atagactcta    180

tgatgaagta caagaggtgg tttattttcc tgctgtagtt catgataacc tgggagaacg    240

tcttaagtgt acatatatag aaattgatca agttcctgaa acatatgctg ttgtcctgag    300

tcgcccagcg tggttgtggg gggcagaaat gggagccaat gagcatggag tttgcattgg    360

gaatgaagct gtatggggaa gagaagaagt ttgtgatgaa gaagcactat taggaatgga    420

ccttgtcaga cttggccttg aaagagctga tacagctgaa aaagccctca atgtcattgt    480

tgacttacta gaaaaatatg gccagggtgg aaattgcaca gagggtagaa tggtatttag    540

ctatcacaac agtttcctga tagctgatag gaatgaagcc tggattctgg agactgcagg    600

gaagtactgg gcagcagaaa aagtacaaga gggagttcgt aatatttcta atcaactttc    660

cataacaacc aagattgccc gggaacaccc agacatgaga aactatgcta agcggaaagg    720

ttggtgggat ggtaaaaagg agtttgattt tgctgcagca tattcctatc ttgacacagc    780

caagatgatg acttcatcag gcagatactg tgagggctac aagcttctaa ataagcacaa    840

aggaaatata acttttgaaa caatgatgga aattcttcga gataaaccaa gtggcattaa    900

tatggaggga gaattcctga ccactgcaag catggtttct attttacctc aagactccag    960

ccttccttgc attcacttct ttacagggac tcctgatcct gagagatctg tttttaagcc   1020

tttcatattt gtgccacata tttcacaact attggatacc agttcaccaa catttgaact   1080

tgaagatcta gttaaaaaga aatcacattt taagcctgac agaagacacc cactctacca   1140

aaaacatcaa caggcattgg aagtagtaaa taataatgag gaaaaagcca aaataatgtt   1200

ggacaacatg aggaaactgg agaaagaact attcagagag atggaatcaa tccttcaaaa   1260

caagcatctt gatgtggaga aaattgttaa tctctttcct cagtgtacaa aagatgaaat   1320

tcaaatttat cagtcaaatt tatcagtcaa agttagttct tagtgatcat atggtcagct   1380

aatattagtt cttagtgatc agtggtcagt aatcttcaaa gtcagaatct atcaccttgg   1440

taaattatat aaacctaact tgagcagatc tgattattct tggatagtat tcaagtggta   1500

tcttgactat taaactacgt atagtgttgc tgaaatagaa agaaaacagc attggaattg   1560

gattcatgta tcgtgggata caggtgttat ttcaggtgat gtacttgcat tattttcttt   1620

agccatagta actttttgtc acaataacta agtattcaat tatatataaa gagtgaaaca   1680

ttaaaatgac gcatggattt atatttatta taattatgta gtaccctcaa atcattttgt   1740

cagttacatc aagaaagcag atttttcttt agtcatgaaa aatatctcaa gtggtaagtt   1800

gtttgtgctt taggcaaaca ttaaccagct ctaacaagaa aaatgtctag atttacacat   1860

tgtcaataca gtatattagt tctgcaaatg cacttttgtt aaactcaaac atgctctttg   1920

tcaagacttg gctaaccagt gagcttgtag ctctgattat ctagcatttt tagggtcatt   1980

ctccttaata ggcttttatg ttaataagat atatttttag aagagcttgt ttgggagatt   2040

agagaataag ataaaagaac caaaacctta ggatatactg tttctgggtc tgaaatctct   2100

ctcattgttt acttctgttc actcagtgaa aacagaaaca agaatgaggt agtggcaatg   2160

aaatagaatt attagtatat tatgaacatt ataacatttt gaacactata atgcattata   2220

tattatgaac ttttatgaac tttatacatg agtaatagct tcctaaagtt tataaaacat   2280

tgtttaggtt acataaagat taccaagtaa gactcaaaat tgcaaatata aacaaaagaa   2340

aaatccaact gaaaataaca ctaagtattt ttgagttcct agaatgtcca ttttggtatt   2400

tggttacatt atcatattta ctagtcacta tcagcacaat taggttaata aagaagtggg   2460

tcattatatt caaagagtgc tcaggaagtt atgtgttcaa agttctctca taaataccat   2520

cgtctgcctg atactgctct tgtctaatag agggttgaca ttacaaaaga aaagatgtct   2580

gactcaagaa ctcagttgat tctgtttgcc ttaagtttgg ttcagtgata ggctgtcttc   2640

taacccctat actcctcttc tctcctttaa tagatgagga aactaagggc aaacagttcg   2700

ttacacttac gggaatctta tttccctctc taggggcagc atgttttcac cttctccttt   2760

gctgccacct tggcctaaac tagcaccgtc ttttagctag accattgcgt taactgttct   2820

cctacaccca tttttgttct ttatttccac ccacatgagt cactgcagcc aatctattac   2880

aaatttaaat ctgattatga attcccctcc taaaactctt ttttaaaaga gactttattt   2940

tttggagcag ttttaggttc acagcaaaat tgaacagaaa gtacagagtt ccaatacagc   3000

ccctatcagc atacatgcat agcctccccc actatcaaca tcccagcacc agaatggtac   3060

atttgttaga atcaatggcc ctacattgac acattatcac ccaaaggcca tggttcaagt   3120

tagagatcac tcttgatgta gtacatccta tgggctttga taattataaa atgacatgta   3180

tccaccatta tagtattata cagagtagtt tcactgccct aaaaatcttc tgtgttctgc   3240

ctatttatcc caccctccct ccaacccctg gcaaccactg atctttttac tgtctccata   3300

gttttgcctt ttccatatgt catatcattg gaatcataca gtatgtgacc tcttaagatt   3360

gtcttcttta acttacttag taatatccat ttaaggttcc tgcatgtctt ttcatgactt   3420

gatagctcat ttcttttagt gctaagtaat attcgattgt ctgaatatac tactactgaa   3480

ggacatcttg gttgcttcca agttt                                         3505


<210>  8814
<211>  424
<212>  PRT
<213>  Homosapiens

<400>  8814

Met Glu Pro Phe Ser Cys Asp Thr Phe Val Ala Leu Pro Pro Ala Thr 
1               5                   10                  15      


Val Asp Asn Arg Ile Ile Phe Gly Lys Asn Ser Asp Arg Leu Tyr Asp 
            20                  25                  30          


Glu Val Gln Glu Val Val Tyr Phe Pro Ala Val Val His Asp Asn Leu 
        35                  40                  45              


Gly Glu Arg Leu Lys Cys Thr Tyr Ile Glu Ile Asp Gln Val Pro Glu 
    50                  55                  60                  


Thr Tyr Ala Val Val Leu Ser Arg Pro Ala Trp Leu Trp Gly Ala Glu 
65                  70                  75                  80  


Met Gly Ala Asn Glu His Gly Val Cys Ile Gly Asn Glu Ala Val Trp 
                85                  90                  95      


Gly Arg Glu Glu Val Cys Asp Glu Glu Ala Leu Leu Gly Met Asp Leu 
            100                 105                 110         


Val Arg Leu Gly Leu Glu Arg Ala Asp Thr Ala Glu Lys Ala Leu Asn 
        115                 120                 125             


Val Ile Val Asp Leu Leu Glu Lys Tyr Gly Gln Gly Gly Asn Cys Thr 
    130                 135                 140                 


Glu Gly Arg Met Val Phe Ser Tyr His Asn Ser Phe Leu Ile Ala Asp 
145                 150                 155                 160 


Arg Asn Glu Ala Trp Ile Leu Glu Thr Ala Gly Lys Tyr Trp Ala Ala 
                165                 170                 175     


Glu Lys Val Gln Glu Gly Val Arg Asn Ile Ser Asn Gln Leu Ser Ile 
            180                 185                 190         


Thr Thr Lys Ile Ala Arg Glu His Pro Asp Met Arg Asn Tyr Ala Lys 
        195                 200                 205             


Arg Lys Gly Trp Trp Asp Gly Lys Lys Glu Phe Asp Phe Ala Ala Ala 
    210                 215                 220                 


Tyr Ser Tyr Leu Asp Thr Ala Lys Met Met Thr Ser Ser Gly Arg Tyr 
225                 230                 235                 240 


Cys Glu Gly Tyr Lys Leu Leu Asn Lys His Lys Gly Asn Ile Thr Phe 
                245                 250                 255     


Glu Thr Met Met Glu Ile Leu Arg Asp Lys Pro Ser Gly Ile Asn Met 
            260                 265                 270         


Glu Gly Glu Phe Leu Thr Thr Ala Ser Met Val Ser Ile Leu Pro Gln 
        275                 280                 285             


Asp Ser Ser Leu Pro Cys Ile His Phe Phe Thr Gly Thr Pro Asp Pro 
    290                 295                 300                 


Glu Arg Ser Val Phe Lys Pro Phe Ile Phe Val Pro His Ile Ser Gln 
305                 310                 315                 320 


Leu Leu Asp Thr Ser Ser Pro Thr Phe Glu Leu Glu Asp Leu Val Lys 
                325                 330                 335     


Lys Lys Ser His Phe Lys Pro Asp Arg Arg His Pro Leu Tyr Gln Lys 
            340                 345                 350         


His Gln Gln Ala Leu Glu Val Val Asn Asn Asn Glu Glu Lys Ala Lys 
        355                 360                 365             


Ile Met Leu Asp Asn Met Arg Lys Leu Glu Lys Glu Leu Phe Arg Glu 
    370                 375                 380                 


Met Glu Ser Ile Leu Gln Asn Lys His Leu Asp Val Glu Lys Ile Val 
385                 390                 395                 400 


Asn Leu Phe Pro Gln Cys Thr Lys Asp Glu Ile Gln Ile Tyr Gln Ser 
                405                 410                 415     


Asn Leu Ser Val Lys Val Ser Ser 
            420                 


<210>  8815
<211>  995
<212>  DNA
<213>  Homosapiens

<400>  8815
gcttccggca actgatgcct ccactggcca ctcctccctc cgtccacctg tcacttcggg     60

tagctgggag gccagtgtac atatatagaa attgatcaag ttcctgaaac atatgctgtt    120

gtcctgagtc gcccagcgtg gttgtggggg gcagaaatgg gagccaatga gcatggagtt    180

tgcattggga atgaagctgt atggggaaga gaagaagttt gtgatgaaga agcactatta    240

ggaatggacc ttgtcagact tggccttgaa agagctgata cagctgaaaa agccctcaat    300

gtcattgttg acttactaga aaaatatggc cagggtggaa attgcacaga gggtagaatg    360

gtatttagct atcacaacag tttcctgata gctgatagga atgaagcctg gattctggag    420

actgcaggga agtactgggc agcagaaaaa gtacaagagg gagttcgtaa tatttctaat    480

caactttcca taacaaccaa gattgcccgg gaacacccag acatgagaaa ctatgctaag    540

cggaaaggtt ggtgggatgg taaaaaggag tttgattttg ctgcagcata ttcctatctt    600

gacacagcca agatgatgac ttcatcaggc agatactgtg agggctacaa gcttctaaat    660

aagcacaaag gaaatataac ttttgaaaca atgatggaaa ttcttcgaga taaaccaagt    720

ggcattaata tggagggaga attcctgacc actgcaagca tggtttctat tttacctcaa    780

gactccagcc ttccttgcat tcacttcttt acagggactc ctgatcctga gagatctgtt    840

tttaagcctt tcatatttgt gccacatatt tcacaactat tggataccag ttcaccaaca    900

tttgaacttg aagatctagt taaaaagaaa tcacatttta agcctgacag aagacaccca    960

ctctaccaaa aacatcaaca ggcattggaa gtagt                               995


<210>  8816
<211>  278
<212>  PRT
<213>  Homosapiens

<400>  8816

Met Gly Ala Asn Glu His Gly Val Cys Ile Gly Asn Glu Ala Val Trp 
1               5                   10                  15      


Gly Arg Glu Glu Val Cys Asp Glu Glu Ala Leu Leu Gly Met Asp Leu 
            20                  25                  30          


Val Arg Leu Gly Leu Glu Arg Ala Asp Thr Ala Glu Lys Ala Leu Asn 
        35                  40                  45              


Val Ile Val Asp Leu Leu Glu Lys Tyr Gly Gln Gly Gly Asn Cys Thr 
    50                  55                  60                  


Glu Gly Arg Met Val Phe Ser Tyr His Asn Ser Phe Leu Ile Ala Asp 
65                  70                  75                  80  


Arg Asn Glu Ala Trp Ile Leu Glu Thr Ala Gly Lys Tyr Trp Ala Ala 
                85                  90                  95      


Glu Lys Val Gln Glu Gly Val Arg Asn Ile Ser Asn Gln Leu Ser Ile 
            100                 105                 110         


Thr Thr Lys Ile Ala Arg Glu His Pro Asp Met Arg Asn Tyr Ala Lys 
        115                 120                 125             


Arg Lys Gly Trp Trp Asp Gly Lys Lys Glu Phe Asp Phe Ala Ala Ala 
    130                 135                 140                 


Tyr Ser Tyr Leu Asp Thr Ala Lys Met Met Thr Ser Ser Gly Arg Tyr 
145                 150                 155                 160 


Cys Glu Gly Tyr Lys Leu Leu Asn Lys His Lys Gly Asn Ile Thr Phe 
                165                 170                 175     


Glu Thr Met Met Glu Ile Leu Arg Asp Lys Pro Ser Gly Ile Asn Met 
            180                 185                 190         


Glu Gly Glu Phe Leu Thr Thr Ala Ser Met Val Ser Ile Leu Pro Gln 
        195                 200                 205             


Asp Ser Ser Leu Pro Cys Ile His Phe Phe Thr Gly Thr Pro Asp Pro 
    210                 215                 220                 


Glu Arg Ser Val Phe Lys Pro Phe Ile Phe Val Pro His Ile Ser Gln 
225                 230                 235                 240 


Leu Leu Asp Thr Ser Ser Pro Thr Phe Glu Leu Glu Asp Leu Val Lys 
                245                 250                 255     


Lys Lys Ser His Phe Lys Pro Asp Arg Arg His Pro Leu Tyr Gln Lys 
            260                 265                 270         


His Gln Gln Ala Leu Glu 
        275             


<210>  8817
<211>  954
<212>  DNA
<213>  Homosapiens

<400>  8817
gaaatgcaga aatcacccct cttctgcgtc gctcacgctg ggagctgtag accagagctg     60

ttcctattcg gccatcttgg ctcctccaga ataaacctat tttttgagga aatataactt    120

ttgaaacaat gatggaaatt cttcgagata aaccaagtgg cattaatatg gagggagaat    180

tcctgaccac tgcaagcatg gtttctattt tacctcaaga ctccagcctt ccttgcattc    240

acttctttac agggactcct gatcctgaga gatctgtttt taagcctttc atatttgtgc    300

cacatatttc acaactattg gataccagtt caccaacatt tgaacttgaa gatctagtta    360

aaaagaaatc acattttaag cctgacagaa gacacccact ctaccaaaaa catcaacagg    420

cattggaagt agtaaataat aatgaggaaa aagccaaaat aatgttggac aacatgagga    480

aactggagaa agaactattc agagagatgg aatcaatcct tcaaaacaag catcttgatg    540

tggagaaaat tgttaatctc tttcctcagt gtacaaaaga tgaaattcaa atttatcagt    600

caaatttatc agtcaaagtt agttcttagt gatcatatgg tcagctaata ttagttctta    660

gtgatcagtg gtcagtaatc ttcaaagtca gaatctatca ccttggtaaa ttatataaac    720

ctaacttgag cagatctgat tattcttgga tagtattcaa gtggtatctt gactattaaa    780

ctacgtatag tgttgctgaa atagaaagaa aacagcattg gaattggatt catgtatcgt    840

gggatacagg tgttatttca ggtgatgtac ttgcattatt ttctttagcc atagtaactt    900

tttgtcacaa taactaagta ttcaattata tataaagagt gaaacattaa aatg          954


<210>  8818
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  8818

Met Met Glu Ile Leu Arg Asp Lys Pro Ser Gly Ile Asn Met Glu Gly 
1               5                   10                  15      


Glu Phe Leu Thr Thr Ala Ser Met Val Ser Ile Leu Pro Gln Asp Ser 
            20                  25                  30          


Ser Leu Pro Cys Ile His Phe Phe Thr Gly Thr Pro Asp Pro Glu Arg 
        35                  40                  45              


Ser Val Phe Lys Pro Phe Ile Phe Val Pro His Ile Ser Gln Leu Leu 
    50                  55                  60                  


Asp Thr Ser Ser Pro Thr Phe Glu Leu Glu Asp Leu Val Lys Lys Lys 
65                  70                  75                  80  


Ser His Phe Lys Pro Asp Arg Arg His Pro Leu Tyr Gln Lys His Gln 
                85                  90                  95      


Gln Ala Leu Glu Val Val Asn Asn Asn Glu Glu Lys Ala Lys Ile Met 
            100                 105                 110         


Leu Asp Asn Met Arg Lys Leu Glu Lys Glu Leu Phe Arg Glu Met Glu 
        115                 120                 125             


Ser Ile Leu Gln Asn Lys His Leu Asp Val Glu Lys Ile Val Asn Leu 
    130                 135                 140                 


Phe Pro Gln Cys Thr Lys Asp Glu Ile Gln Ile Tyr Gln Ser Asn Leu 
145                 150                 155                 160 


Ser Val Lys Val Ser Ser 
                165     


<210>  8819
<211>  2771
<212>  DNA
<213>  Homosapiens

<400>  8819
gaaatgcaga aatcacccct cttctgcgtc gctcacgctg ggagctgtag accagagctg     60

ttcctattcg gccatcttgg ctcctccaga ataaacctat tttttgagga aatataactt    120

ttgaaacaat gatggaaatt cttcgagata aaccaagtgg cattaatatg gagggagaat    180

tcctgaccac tgcaagcatg gtttctattt tacctcaaga ctccagcctt ccttgcattc    240

acttctttac agggactcct gatcctgaga gatctgtttt taagcctttc atatttgtgc    300

cacatatttc acaactattg gataccagtt caccaacatt tgaacttgaa gatctagtta    360

aaaagaaatc acattttaag cctgacagaa gacacccact ctaccaaaaa catcaacagg    420

cattggaagt agtaaataat aatgaggaaa aagccaaaat aatgttggac aacatgagga    480

aactggagaa agaactattc agagagatgg aatcaatcct tcaaaacaag catcttgatg    540

tggagaaaat tgttaatctc tttcctcagt gtacaaaaga tgaaattcaa atttatcagt    600

caaatttatc agtcaaagtt agttcttagt gatcatatgg tcagctaata ttagttctta    660

gtgatcagtg gtcagtaatc ttcaaagtca gaatctatca ccttggtaaa ttatataaac    720

ctaacttgag cagatctgat tattcttgga tagtattcaa gtggtatctt gactattaaa    780

ctacgtatag tgttgctgaa atagaaagaa aacagcattg gaattggatt catgtatcgt    840

gggatacagg tgttatttca ggtgatgtac ttgcattatt ttctttagcc atagtaactt    900

tttgtcacaa taactaagta ttcaattata tataaagagt gaaacattaa aatgacgcat    960

ggatttatat ttattataat tatgtagtac cctcaaatca ttttgtcagt tacatcaaga   1020

aagcagattt ttctttagtc atgaaaaata tctcaagtgg taagttgttt gtgctttagg   1080

caaacattaa ccagctctaa caagaaaaat gtctagattt acacattgtc aatacagtat   1140

attagttctg caaatgcact tttgttaaac tcaaacatgc tctttgtcaa gacttggcta   1200

accagtgagc ttgtagctct gattatctag catttttagg gtcattctcc ttaataggct   1260

tttatgttaa taagatatat ttttagaaga gcttgtttgg gagattagag aataagataa   1320

aagaaccaaa accttaggat atactgtttc tgggtctgaa atctctctca ttgtttactt   1380

ctgttcactc agtgaaaaca gaaacaagaa tgaggtagtg gcaatgaaat agaattatta   1440

gtatattatg aacattataa cattttgaac actataatgc attatatatt atgaactttt   1500

atgaacttta tacatgagta atagcttcct aaagtttata aaacattgtt taggttacat   1560

aaagattacc aagtaagact caaaattgca aatataaaca aaagaaaaat ccaactgaaa   1620

ataacactaa gtatttttga gttcctagaa tgtccatttt ggtatttggt tacattatca   1680

tatttactag tcactatcag cacaattagg ttaataaaga agtgggtcat tatattcaaa   1740

gagtgctcag gaagttatgt gttcaaagtt ctctcataaa taccatcgtc tgcctgatac   1800

tgctcttgtc taatagaggg ttgacattac aaaagaaaag atgtctgact caagaactca   1860

gttgattctg tttgccttaa gtttggttca gtgataggct gtcttctaac ccctatactc   1920

ctcttctctc ctttaataga tgaggaaact aagggcaaac agttcgttac acttacggga   1980

atcttatttc cctctctagg ggcagcatgt tttcaccttc tcctttgctg ccaccttggc   2040

ctaaactagc accgtctttt agctagacca ttgcgttaac tgttctccta cacccatttt   2100

tgttctttat ttccacccac atgagtcact gcagccaatc tattacaaat ttaaatctga   2160

ttatgaattc ccctcctaaa actctttttt aaaagagact ttattttttg gagcagtttt   2220

aggttcacag caaaattgaa cagaaagtac agagttccaa tacagcccct atcagcatac   2280

atgcatagcc tcccccacta tcaacatccc agcaccagaa tggtacattt gttagaatca   2340

atggccctac attgacacat tatcacccaa aggccatggt tcaagttaga gatcactctt   2400

gatgtagtac atcctatggg ctttgataat tataaaatga catgtatcca ccattatagt   2460

attatacaga gtagtttcac tgccctaaaa atcttctgtg ttctgcctat ttatcccacc   2520

ctccctccaa cccctggcaa ccactgatct ttttactgtc tccatagttt tgccttttcc   2580

atatgtcata tcattggaat catacagtat gtgacctctt aagattgtct tctttaactt   2640

acttagtaat atccatttaa ggttcctgca tgtcttttca tgacttgata gctcatttct   2700

tttagtgcta agtaatattc gattgtctga atatactact actgaaggac atcttggttg   2760

cttccaagtt t                                                        2771


<210>  8820
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  8820

Met Met Glu Ile Leu Arg Asp Lys Pro Ser Gly Ile Asn Met Glu Gly 
1               5                   10                  15      


Glu Phe Leu Thr Thr Ala Ser Met Val Ser Ile Leu Pro Gln Asp Ser 
            20                  25                  30          


Ser Leu Pro Cys Ile His Phe Phe Thr Gly Thr Pro Asp Pro Glu Arg 
        35                  40                  45              


Ser Val Phe Lys Pro Phe Ile Phe Val Pro His Ile Ser Gln Leu Leu 
    50                  55                  60                  


Asp Thr Ser Ser Pro Thr Phe Glu Leu Glu Asp Leu Val Lys Lys Lys 
65                  70                  75                  80  


Ser His Phe Lys Pro Asp Arg Arg His Pro Leu Tyr Gln Lys His Gln 
                85                  90                  95      


Gln Ala Leu Glu Val Val Asn Asn Asn Glu Glu Lys Ala Lys Ile Met 
            100                 105                 110         


Leu Asp Asn Met Arg Lys Leu Glu Lys Glu Leu Phe Arg Glu Met Glu 
        115                 120                 125             


Ser Ile Leu Gln Asn Lys His Leu Asp Val Glu Lys Ile Val Asn Leu 
    130                 135                 140                 


Phe Pro Gln Cys Thr Lys Asp Glu Ile Gln Ile Tyr Gln Ser Asn Leu 
145                 150                 155                 160 


Ser Val Lys Val Ser Ser 
                165     


<210>  8821
<211>  7456
<212>  DNA
<213>  Homosapiens

<400>  8821
gcggccggcg aggggctgag ctgacagggc cgcatcggct taccccacct tactttatcg     60

gaacgtgcct aagctgctgc agctggcacc cggttgcgct cggcgaagag ggctgggggc    120

gggagatgac ggtggtcttc tccctgcttg gcaccctgcg agcaccagct cccttctcct    180

cgccactcca aggttgcaga cgaagcagag atctggttgg agttggaggg tgagagaaaa    240

tgaattctaa tttacctgca gagaacttaa ccattgcagt caatatgacc aagactttgc    300

ctacagcagt aacgcatgga tttaattcca ctaatgaccc accttcaatg tcaattacaa    360

ggctttttcc agccttactg gaatgctttg gcattgtcct ttgtggctac atagcaggaa    420

gggccaatgt cataacatca acccaggcca aaggactagg aaattttgtc tccagatttg    480

cacttccagc tttattattc aaaaacatgg ttgtacttaa tttttccaat gtggactggt    540

ccttcctata tagtatctta attgccaaag cttctgtatt tttcattgta tgtgtattaa    600

ccttattggt tgccagtcct gatagtcgat ttagcaaagc tggactattc cctatttttg    660

ctacacaaag taatgacttt gcattgggat accctatagt tgaagcttta tatcaaacta    720

catacccaga atatctccag tacatttatt tggtggcacc aatatctctt atgatgttaa    780

accctatagg gtttattttc tgtgaaatcc aaaagtggaa agacactcaa aatgcttctc    840

aaaataaaat aaaaattgtg ggactcggac tcctgcgtgt attacagaac ccaatagtat    900

ttatggtctt cattggcatc gccttcaatt ttattcttga tcgaaaggta cctgtatatg    960

tcgaaaattt tcttgatgga cttggaaatt ctttttctgg atcagcccta ttttatcttg   1020

gtctcacgat ggtgggaaaa ataaagagac tgaagaagtc ggcatttgta gtactaattc   1080

ttctcatcac agctaaactt ctggtgctgc cacttctgtg cagagaaatg gtggaactct   1140

tggacaaggg cgacagtgtg gtgaaccata caagtttatc aaattatgca tttctgtatg   1200

gtgtatttcc tgtagcacca ggagtggcta tctttgcaac acaattcaac atggaagtag   1260

aaattataac ctcagggatg gtgataagca catttgtgtc tgctcccatc atgtacgttt   1320

ctgcctggtt actgaccttt cccactatgg accctaagcc attggcatat gccatccaga   1380

atgttagttt tgatataagt attgtcagcc tgatctcctt gtctattgtc tgtgctggaa   1440

tgatgatatg gaattttgtt aaagaaaaaa attttgttgg acaaattttg gtgtttgttc   1500

tattgtacag ctccctctat agcacctacc tgtggacagg ccttctagca atttctttgt   1560

ttcttttgaa aaagcgagag agggtacaaa ttcctgttgg aataatcata atatctggct   1620

ggggaattcc tgctctcctt gttggtgttc ttttgataac tggaaaacac aatggagata   1680

gcattgactc agccttcttt tatggaaaag aacagatgat caccacagca gtcaccctgt   1740

tctgcagcat cctgatagct ggcatatccc tcatgtgcat gaaccagact gcccaagcag   1800

gaagctatga aggtttcgat cagtctcaga gccacaaagt ggtggagcct ggaaatactg   1860

cttttgagga gagtccagca ccagtaaatg aaccagaact ttttacaagc tctattccag   1920

aaacaagttg ctgctcctgc tccatgggaa atggtgaatt acactgccca tcaatagagc   1980

caatagcaaa cacaagcacc agtgagcctg tgattccttc gtttgagaaa aacaatcatt   2040

gtgtgagtcg ctgtaactcc cagagctgca tattagccca ggaagaagaa cagtatctac   2100

agagtggaga ccagcaactg acccgacatg tgttgctgtg tttacttctc atcattggcc   2160

tgttcgctaa tctttccagt tgtttatggt ggctattcaa ccaagagcct ggaagacttt   2220

atgttgagtt acagtttttc tgtgccgtgt ttaactttgg tcagggattt atttcctttg   2280

gaatctttgg attagataaa catttaatca tcctgccttt caaaagaaga cttgaattcc   2340

tatggaacaa taaagacaca gcagaaaaca gggattctcc tgtttcagag gaaataaaaa   2400

tgacctgtca acaatttatc cattatcacc gtgacctctg tatccgaaac attgtcaaag   2460

aaagaaggtg tggtgcaaag acttctgctg gaactttctg tggctgtgac ctggtgagct   2520

ggctaattga agtcggcctt gcctccgacc gtggtgaagc tgtgatatac ggagacaggc   2580

tggtacaagg gggagtcatc caacatatta ccaacgagta tgaattccgg gatgagtact   2640

tgttttacag atttcttcaa aagagtcctg aacagagtcc tcctgctatt aatgcaaaca   2700

ctctccaaca ggaaagatat aaagaaattg agcattcatc cccaccctca cattccccta   2760

agacctaaat tatgcagggg agaaccctac atggaatcat attctagccg cgtattcatt   2820

agtttttagc tgggtgacct tgggcaagtt aacagaggca acctctctga gcctcagttg   2880

tctcttctgt aaaatgtgaa aagatgtgct cccaccacat gcgcagggtc tgtgatttta   2940

catgtatgta aaacacatag gaagctgact taggaaaaag agaaaaccaa attaaagttc   3000

tgataatgaa tataatatag tcatccttta gtatccaagg ggattggttc caggactcct   3060

gaagatccca aaatctgagg atactcaagt cccttatata aaatggtgta ggccgggcat   3120

ggtggctcac gcctgtaatc ccagtacttt gggaggccga gtcaggtgga tcacctgagg   3180

tcaggagttc aagaccagcc tggccaacat ggcgaaaccc cgtctctact ataaaataca   3240

aaaaattagt tgggtgtggt ggcgggtgcc tgtaatccca gctactcagg aggctgaggc   3300

aggagaatcg cttgaatctg ggaggcagag gttgctgtga gccgagatcg tgccactgca   3360

ctccagcctg agcaacagag caagactcta tctcaaaaat aaaataaaat aaaataaaat   3420

aattaataaa atggtgtagt atttgcatat aacctatgca cattctccca tatagtttaa   3480

tcatctttag atacttataa tgcctaatac aatgtaaatg ctatgtaaat agttgttgtt   3540

atactgtatt gtttagggaa taacaataag aaaaacagtc tgtacatgtt cactacagat   3600

gcaaccattg ttaagcctga ctacatcttt ttatctgcgg ttgattgaat ctatggatgt   3660

ggaacctgtg catatggagg gtcaactgta ctataaataa tacgaatatg ccaacattat   3720

ataatcattg ctttctgcaa ctgtttacta taatttcaaa attaatatcc tattaactgt   3780

tcctataaat tatcaaattt ggcaagtgta ttactagcag gagatggacc ttaaattatg   3840

acaactttat attttttgat agcatctctt gaaaaagaat tttaatgatt ctaataagag   3900

gttctttttc ttttttccat ttccttgaca aatagtactc atttaaaaac tagagggcta   3960

ggcttagtgg ctcacgcctg taatctcagc actttgggag gctgaggcgg gcagatcgct   4020

tgaggtcagg agttcaagac cagcccgggc aacgtggtga aacccggtct gtactaaaaa   4080

aaaaaaaaaa gaaaaagaaa aagaaaaaag aatacccagg tgtggtagtg catgcctgta   4140

gtcccagcta ctttggagac tgaggtggga gtaccccttg agcctgggag gcgcaggttg   4200

cagtgaacca agatcacatc actgcacttc aacctgggtg acagagcaag accctgtctc   4260

aaaaacaaaa aacaagcaaa aaaaacctag aggcactatt tttttttaaa gtttgtcttt   4320

tcttttctac ccaaattact aatctatgcc attaaggaaa ggaataagaa cctccatatg   4380

tattattatc tccacagtcc tgcagaagta caatctgatc tttaactttc atgctacaaa   4440

taataatttg agtagattaa tttgaatttt atcaacaaaa ttattgccat atgatgtatc   4500

atttctgtgt ttgaacaaag catcgtaatg caggataact tctactttat tccctgtagt   4560

taaaaaaaaa aaaactatat agttcaagcc aatatttaaa aattctaaac ctaggctggg   4620

catggtgact catacctgta atcccagcac tttgggaggc cgaggcaggt gaattgcttc   4680

agcccaggag ttcgagacca gcctggccaa tgtggtgaaa ccccatctct actaaaaaaa   4740

aaaaaaaaaa aaaaaattag ccaggtgtgg tggtgtgcac ctgtaatccc agctacccag   4800

gaggctgagg caggaaaatt gcttgaaacc aggaggcaga ggttgcagtg agctgagatc   4860

gtgccactgc actccagcct gagtgtcaga gtgagactct gtctcagaaa aaaaaaaaaa   4920

aattctaaag attacattta gaatttagtc tttttaaagt gtccatgtat aaaaatatat   4980

aatttttaaa attactaaat gttgcctttt ctcttagtct aatattttag ctactaaaac   5040

aaaatataaa ctggatagct tataaacaac ataaacttat ttctcacagt tttggaggct   5100

gtgaagtcca agattaaggc actaacagat ctagtgtctg gtaaggcaaa tttctggctc   5160

atagatggta ccttcttgct gtgtccccac atggtagatg ggaagaactg gtctcattgg   5220

ccccttataa ggacattaat tccactcaat aggctccacc ctcatgatct aataacctct   5280

caaaggccct acctcctaat actaacacat tgaggatgtg acttcaactt tacatttcta   5340

caggcagaga agtggggctg tgtaaattct tcccatcagt acttgaatgt tcatttaaca   5400

aataacttat cgagcatcta gcatgttcca gacacaatct gaacactgag cacacaacag   5460

ttggaacaaa tatgattcct atcctcatgg agcttctatt ctcctgtgaa aaacagatgt   5520

taaacatgat tgaggattag gtttcaacat aagaattcta ggaggacaca gacatttaga   5580

ccatagcatc ttcaggtaaa ctttatcttc agtaaattaa agagatctat ttagatgacc   5640

tttgagcatc ttaattatta gatgtcagtg ctagtttaac ttattttaaa cgtttcagat   5700

atttatttaa ttatacttta agtgtctcat gtaaaaaagt tatttataaa ataatttata   5760

gggttagagt cattgccctt ttaatgcaac aaataaacag ttttttaaaa acctgcatgg   5820

gggccaggcg cggtggttca tacctgcaat cccagcactt tgggaggtcg aggctggcgg   5880

atcacgaggt caggagatcg agaccaccct gattaatgcg gtgaaatccc gtctctacta   5940

aaaatacaaa aaattagcca gacgtggtgg tgggcaccta tagtcccagc tactcgggag   6000

gctgaggcag gagaatggca tgaacccgga aggcggagct tgcagtgaac caagatcgcg   6060

ccactgcact ccagcctggg cgacagagtg agactccatc gcaaaaaaaa aaaaaaaaaa   6120

acctgcatgg aagcctagta tatttattaa taacaaataa attatacttt agtgtactat   6180

taacctatac caattttaag ttgtgattag ggaatgggga tgtttttaag ctgaattgtc   6240

ttgctgcgga actttccttt tttaataaga ccatattatg actctgaatg ctcaagggta   6300

agtctaaggc ctcattgctg ttaccaggag atttttctag ttacagtaat aaagatgtta   6360

attcacatgc atgcagacaa ctgaaactca agtggagaat ttgtttgtga acaagtcata   6420

ctacttctgt tatttgcatg aatggaatct gcaatatctt tttccatggg agaccctaaa   6480

agaaaaccct ggatcagaat gatctgcagt ttcagataat aaaggctttt aagagacatt   6540

tttagaatta aaaatatgct aattttatta aatgaaaata tttgtaactg ttaactttct   6600

cactgacaaa gcaagtttct caataaaata cctattttaa cttgcattac tgacatcttt   6660

tctttgagta atctgaataa tgcagaagcc atcatagagg tcttttctat acattctcaa   6720

tgttttctta aatgggtttc ctgagttctg ttcttcatga ctctgggctc tgcaaacagg   6780

gtttcccaat tacgcattct ataaacactt ttatgaatga gtcaatatga cattgagtcc   6840

ttttcataca tttcatcatt tccaatatgt agagtgacag ctagaaaaat gataaaattt   6900

tgattaaaac ctatctcttt ttcttcagca tagtcaattg ttttcttaac tctcaatgag   6960

taactccatg cctagcttgt gcttagcttt caatattttt agactaagac aaagtgtatt   7020

tggcattttg agaacaacaa ttaatggtca gtaaatttct aaagcaagaa aaatgtgaaa   7080

ctagtgtttt atatgtttgt tacgcagcag aatgcggctc ttagtgtttg ccccttcata   7140

tctcatcatg taaaatatta aattacttta ggccactgca cataggtagt cctgtcatga   7200

gtgatggctg gagaaaagtt caggatcata aatgttatca tcattcttca agaaaagatg   7260

agattataaa tttctgcaat tggtatgata aaaggttgaa ataattaatg aaaaagaaaa   7320

cattagctct gtagacctgt tttgggcaca ctttacaaga agaaactaac tctccaaaat   7380

tctaggctat gtagttattt ctaaagcaaa acttttgatt catgattaac atatataagc   7440

tggtgttttc atcaaa                                                   7456


<210>  8822
<211>  842
<212>  PRT
<213>  Homosapiens

<400>  8822

Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met 
1               5                   10                  15      


Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn 
            20                  25                  30          


Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu 
        35                  40                  45              


Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val 
    50                  55                  60                  


Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser 
                85                  90                  95      


Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser 
            100                 105                 110         


Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp 
        115                 120                 125             


Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser 
    130                 135                 140                 


Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr 
145                 150                 155                 160 


Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser 
                165                 170                 175     


Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys 
            180                 185                 190         


Trp Lys Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly 
        195                 200                 205             


Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe 
    210                 215                 220                 


Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr 
225                 230                 235                 240 


Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala 
                245                 250                 255     


Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys 
            260                 265                 270         


Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu 
        275                 280                 285             


Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly 
    290                 295                 300                 


Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr 
305                 310                 315                 320 


Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe 
                325                 330                 335     


Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe 
            340                 345                 350         


Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro 
        355                 360                 365             


Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe 
    370                 375                 380                 


Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ser Ile Val Cys Ala Gly 
385                 390                 395                 400 


Met Met Ile Trp Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile 
                405                 410                 415     


Leu Val Phe Val Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Trp 
            420                 425                 430         


Thr Gly Leu Leu Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg 
        435                 440                 445             


Val Gln Ile Pro Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro 
    450                 455                 460                 


Ala Leu Leu Val Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp 
465                 470                 475                 480 


Ser Ile Asp Ser Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr 
                485                 490                 495     


Ala Val Thr Leu Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met 
            500                 505                 510         


Cys Met Asn Gln Thr Ala Gln Ala Gly Ser Tyr Glu Gly Phe Asp Gln 
        515                 520                 525             


Ser Gln Ser His Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu 
    530                 535                 540                 


Ser Pro Ala Pro Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro 
545                 550                 555                 560 


Glu Thr Ser Cys Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys 
                565                 570                 575     


Pro Ser Ile Glu Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile 
            580                 585                 590         


Pro Ser Phe Glu Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln 
        595                 600                 605             


Ser Cys Ile Leu Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp 
    610                 615                 620                 


Gln Gln Leu Thr Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly 
625                 630                 635                 640 


Leu Phe Ala Asn Leu Ser Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu 
                645                 650                 655     


Pro Gly Arg Leu Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn 
            660                 665                 670         


Phe Gly Gln Gly Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His 
        675                 680                 685             


Leu Ile Ile Leu Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn 
    690                 695                 700                 


Lys Asp Thr Ala Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys 
705                 710                 715                 720 


Met Thr Cys Gln Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg 
                725                 730                 735     


Asn Ile Val Lys Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr 
            740                 745                 750         


Phe Cys Gly Cys Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala 
        755                 760                 765             


Ser Asp Arg Gly Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly 
    770                 775                 780                 


Gly Val Ile Gln His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr 
785                 790                 795                 800 


Leu Phe Tyr Arg Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala 
                805                 810                 815     


Ile Asn Ala Asn Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His 
            820                 825                 830         


Ser Ser Pro Pro Ser His Ser Pro Lys Thr 
        835                 840         


<210>  8823
<211>  6645
<212>  DNA
<213>  Homosapiens

<400>  8823
gcggccggcg aggggctgag ctgacagggc cgcatcggct taccccacct tactttatcg     60

gaacgtgcct aagctgctgc agctggcacc cggttgcgct cggcgaagag ggctgggggc    120

gggagatgac ggtggtcttc tccctgcttg gcaccctgcg agcaccagct cccttctcct    180

cgccactcca aggttgcaga cgaagcagag atctggttgg agttggaggg tgagagaaaa    240

tgaattctaa tttacctgca gagaacttaa ccattgcagt caatatgacc aagactttgc    300

ctacagcagt aacgcatgga tttaattcca ctaatgaccc accttcaatg tcaattacaa    360

ggctttttcc agccttactg gaatgctttg gcattgtcct ttgtggctac atagcaggaa    420

gggccaatgt cataacatca acccaggcca aaggactagg aaattttgtc tccagatttg    480

cacttccagc tttattattc aaaaacatgg ttgtacttaa tttttccaat gtggactggt    540

ccttcctata tagtatctta attgccaaag cttctgtatt tttcattgta tgtgtattaa    600

ccttattggt tgccagtcct gatagtcgat ttagcaaagc tggactattc cctatttttg    660

ctacacaaag taatgacttt gcattgggat accctatagt tgaagcttta tatcaaacta    720

catacccaga atatctccag tacatttatt tggtggcacc aatatctctt atgatgttaa    780

accctatagg gtttattttc tgtgaaatcc aaaagtggaa agacactcaa aatgcttctc    840

aaaataaaat aaaaattgtg ggactcggac tcctgcgtgt attacagaac ccaatagtat    900

ttatggtctt cattggcatc gccttcaatt ttattcttga tcgaaaggta cctgtatatg    960

tcgaaaattt tcttgatgga cttggaaatt ctttttctgg atcagcccta ttttatcttg   1020

gtctcacgat ggtgggaaaa ataaagagac tgaagaagtc ggcatttgta gtactaattc   1080

ttctcatcac agctaaactt ctggtgctgc cacttctgtg cagagaaatg gtggaactct   1140

tggacaaggg cgacagtgtg gtgaaccata caagtttatc aaattatgca tttctgtatg   1200

gtgtatttcc tgtagcacca ggagtggcta tctttgcaac acaattcaac atggaagtag   1260

aaattataac ctcagggatg gtgataagca catttgtgtc tgctcccatc atgtacgttt   1320

ctgcctggtt actgaccttt cccactatgg accctaagcc attggcatat gccatccaga   1380

atgttagttt tgatataagt attgtcagcc tgatctcctt gtctattgtc tgtgctggaa   1440

tgatgatatg gaattttgtt aaagaaaaaa attttgttgg acaaattttg gtgtttgttc   1500

tattgtacag ctccctctat agcacctacc tgtggacagg ccttctagca atttctttgt   1560

ttcttttgaa aaagcgagag agggtacaaa ttcctgttgg aataatcata atatctggct   1620

ggggaattcc tgctctcctt gttggtgttc ttttgataac tggaaaacac aatggagata   1680

gcattgactc agccttcttt tatggaaaag aacagatgat caccacagca gtcaccctgt   1740

tctgcagcat cctgatagct ggcatatccc tcatgtgcat gaaccagact gcccaagcag   1800

gaagctatga aggtttcgat cagtctcaga gccacaaagt ggtggagcct ggaaatactg   1860

cttttgagga gagtccagca ccagtaaatg aaccagaact ttttacaagc tctattccag   1920

aaacaagttg ctgctcctgc tccatgggaa atggtgaatt acactgccca tcaatagagc   1980

caatagcaaa cacaagcacc agtgagcctg tgattccttc gtttgagaaa aacaatcatt   2040

gtgtgagtcg ctgtaactcc cagagctgca tattagccca ggaagaagaa cagtatctac   2100

agagtggaga ccagcaactg acccgacatg tgttgctgtg tttacttctc atcattggcc   2160

tgttcgctaa tctttccagt tgtttatggt ggctattcaa ccaagagcct ggaagacttt   2220

atgttgagtt acagtttttc tgtgccgtgt ttaactttgg tcagggattt atttcctttg   2280

gaatctttgg attagataaa catttaatca tcctgccttt caaaagaaga cttgaattcc   2340

tatggaacaa taaagacaca gcagaaaaca gggattctcc tgtttcagag gaaataaaaa   2400

tgacctgtca acaatttatc cattatcacc gtgacctctg tatccgaaac attgtcaaag   2460

aaagaaggtg tggtgcaaag acttctgctg gaactttctg tggctgtgac ctggtgagct   2520

ggctaattga agtcggcctt gcctccgacc gtggtgaagc tgtgatatac ggagacaggc   2580

tggtacaagg gggagtcatc caacatatta ccaacgagta tgaattccgg gatgagtact   2640

tgttttacag atttcttcaa aagagtcctg aacagagtcc tcctgctatt aatgcaaaca   2700

ctctccaaca ggaaagatat aaagaaattg agcattcatc cccaccctca cattccccta   2760

agacctaaat tatgcagggg agaaccctac atggaatcat attctagccg cgtattcatt   2820

agtttttagc tgggtgacct tgggcaagtt aacagaggca acctctctga gcctcagttg   2880

tctcttctgt aaaatgtgaa aagatgtgct cccaccacat gcgcagggtc tgtgatttta   2940

catgtatgta aaacacatag gaagctgact taggaaaaag agaaaaccaa attaaagttc   3000

tgataatgaa tataatatag tcatccttta gtatccaagg ggattggttc caggactcct   3060

gaagatccca aaatctgagg atactcaagt cccttatata aaatggtgta ggccgggcat   3120

ggtggctcac gcctgtaatc ccagtacttt gggaggccga gtcaggtgga tcacctgagg   3180

tcaggagttc aagaccagcc tggccaacat ggcgaaaccc cgtctctact ataaaataca   3240

aaaaattagt tgggtgtggt ggcgggtgcc tgtaatccca gctactcagg aggctgaggc   3300

aggagaatcg cttgaatctg ggaggcagag gttgctgtga gccgagatcg tgccactgca   3360

ctccagcctg agcaacagag caagactcta tctcaaaaat aaaataaaat aaaataaaat   3420

aattaataaa atggtgtagt atttgcatat aacctatgca cattctccca tatagtttaa   3480

tcatctttag atacttataa tgcctaatac aatgtaaatg ctatgtaaat agttgttgtt   3540

atactgtatt gtttagggaa taacaataag aaaaacagtc tgtacatgtt cactacagat   3600

gcaaccattg ttaagcctga ctacatcttt ttatctgcgg ttgattgaat ctatggatgt   3660

ggaacctgtg catatggagg gtcaactgta ctataaataa tacgaatatg ccaacattat   3720

ataatcattg ctttctgcaa ctgtttacta taatttcaaa attaatatcc tattaactgt   3780

tcctataaat tatcaaattt ggcaagtgta ttactagcag gagatggacc ttaaattatg   3840

acaactttat attttttgat agcatctctt gaaaaagaat tttaatgatt ctaataagag   3900

gttctttttc ttttttccat ttccttgaca aatagtactc atttaaaaac tagagggcta   3960

ggcttagtgg ctcacgcctg taatctcagc actttgggag gctgaggcgg gcagatcgct   4020

tgaggtcagg agttcaagac cagcccgggc aacgtggtga aacccggtct gtactaaaaa   4080

aaaaaaaaaa gaaaaagaaa aagaaaaaag aatacccagg tgtggtagtg catgcctgta   4140

gtcccagcta ctttggagac tgaggtggga gtaccccttg agcctgggag gcgcaggttg   4200

cagtgaacca agatcacatc actgcacttc aacctgggtg acagagcaag accctgtctc   4260

aaaaacaaaa aacaagcaaa aaaaacctag aggcactatt tttttttaaa gtttgtcttt   4320

tcttttctac ccaaattact aatctatgcc attaaggaaa ggaataagaa cctccatatg   4380

tattattatc tccacagtcc tgcagaagta caatctgatc tttaactttc atgctacaaa   4440

taataatttg agtagattaa tttgaatttt atcaacaaaa ttattgccat atgatgtatc   4500

atttctgtgt ttgaacaaag catcgtaatg caggataact tctactttat tccctgtagt   4560

taaaaaaaaa aaaactatat agttcaagcc aatatttaaa aattctaaac ctaggctggg   4620

catggtgact catacctgta atcccagcac tttgggaggc cgaggcaggt gaattgcttc   4680

agcccaggag ttcgagacca gcctggccaa tgtggtgaaa ccccatctct actaaaaaaa   4740

aaaaaaaaaa aaaaaattag ccaggtgtgg tggtgtgcac ctgtaatccc agctacccag   4800

gaggctgagg caggaaaatt gcttgaaacc aggaggcaga ggttgcagtg agctgagatc   4860

gtgccactgc actccagcct gagtgtcaga gtgagactct gtctcagaaa aaaaaaaaaa   4920

aattctaaag attacattta gaatttagtc tttttaaagt gtccatgtat aaaaatatat   4980

aatttttaaa attactaaat gttgcctttt ctcttagtct aatattttag ctactaaaac   5040

aaaatataaa ctggatagct tataaacaac ataaacttat ttctcacagt tttggaggct   5100

gtgaagtcca agattaaggc actaacagat ctagtgtctg gtaaggcaaa tttctggctc   5160

atagatggta ccttcttgct gtgtccccac atggtagatg ggaagaactg gtctcattgg   5220

ccccttataa ggacattaat tccactcaat aggctccacc ctcatgatct aataacctct   5280

caaaggccct acctcctaat actaacacat tgaggatgtg acttcaactt tacatttcta   5340

caggcagaga agtggggctg tgtaaattct tcccatcagt acttgaatgt tcatttaaca   5400

aataacttat cgagcatcta gcatgttcca gacacaatct gaacactgag cacacaacag   5460

ttggaacaaa tatgattcct atcctcatgg agcttctatt ctcctgtgaa aaacagatgt   5520

taaacatgat tgaggattag gtttcaacat aagaattcta ggaggacaca gacatttaga   5580

ccatagcatc ttcaggtaaa ctttatcttc agtaaattaa agagatctat ttagatgacc   5640

tttgagcatc ttaattatta gatgtcagtg ctagtttaac ttattttaaa cgtttcagat   5700

atttatttaa ttatacttta agtgtctcat gtaaaaaagt tatttataaa ataatttata   5760

gggttagagt cattgccctt ttaatgcaac aaataaacag ttttttaaaa acctgcatgg   5820

gggccaggcg cggtggttca tacctgcaat cccagcactt tgggaggtcg aggctggcgg   5880

atcacgaggt caggagatcg agaccaccct gattaatgcg gtgaaatccc gtctctacta   5940

aaaatacaaa aaattagcca gacgtggtgg tgggcaccta tagtcccagc tactcgggag   6000

gctgaggcag gagaatggca tgaacccgga aggcggagct tgcagtgaac caagatcgcg   6060

ccactgcact ccagcctggg cgacagagtg agactccatc gcaaaaaaaa aaaaaaaaaa   6120

acctgcatgg aagcctagta tatttattaa taacaaataa attatacttt agtgtactat   6180

taacctatac caattttaag ttgtgattag ggaatgggga tgtttttaag ctgaattgtc   6240

ttgctgcgga actttccttt tttaataaga ccatattatg actctgaatg ctcaagggta   6300

agtctaaggc ctcattgctg ttaccaggag atttttctag ttacagtaat aaagatgtta   6360

attcacatgc atgcagacaa ctgaaactca agtggagaat ttgtttgtga acaagtcata   6420

ctacttctgt tatttgcatg aatggaatct gcaatatctt tttccatggg agaccctaaa   6480

agaaaaccct ggatcagaat gatctgcagt ttcagataat aaaggctttt aagagacatt   6540

tttagaatta aaaatatgct aattttatta aatgaaaata tttgtaactg ttaactttct   6600

cactgacaaa gcaagtttct caataaaata cctattttaa cttgc                   6645


<210>  8824
<211>  842
<212>  PRT
<213>  Homosapiens

<400>  8824

Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met 
1               5                   10                  15      


Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn 
            20                  25                  30          


Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu 
        35                  40                  45              


Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val 
    50                  55                  60                  


Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser 
                85                  90                  95      


Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser 
            100                 105                 110         


Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp 
        115                 120                 125             


Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser 
    130                 135                 140                 


Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr 
145                 150                 155                 160 


Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser 
                165                 170                 175     


Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys 
            180                 185                 190         


Trp Lys Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly 
        195                 200                 205             


Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe 
    210                 215                 220                 


Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr 
225                 230                 235                 240 


Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala 
                245                 250                 255     


Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys 
            260                 265                 270         


Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu 
        275                 280                 285             


Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly 
    290                 295                 300                 


Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr 
305                 310                 315                 320 


Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe 
                325                 330                 335     


Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe 
            340                 345                 350         


Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro 
        355                 360                 365             


Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe 
    370                 375                 380                 


Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ser Ile Val Cys Ala Gly 
385                 390                 395                 400 


Met Met Ile Trp Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile 
                405                 410                 415     


Leu Val Phe Val Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Trp 
            420                 425                 430         


Thr Gly Leu Leu Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg 
        435                 440                 445             


Val Gln Ile Pro Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro 
    450                 455                 460                 


Ala Leu Leu Val Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp 
465                 470                 475                 480 


Ser Ile Asp Ser Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr 
                485                 490                 495     


Ala Val Thr Leu Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met 
            500                 505                 510         


Cys Met Asn Gln Thr Ala Gln Ala Gly Ser Tyr Glu Gly Phe Asp Gln 
        515                 520                 525             


Ser Gln Ser His Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu 
    530                 535                 540                 


Ser Pro Ala Pro Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro 
545                 550                 555                 560 


Glu Thr Ser Cys Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys 
                565                 570                 575     


Pro Ser Ile Glu Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile 
            580                 585                 590         


Pro Ser Phe Glu Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln 
        595                 600                 605             


Ser Cys Ile Leu Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp 
    610                 615                 620                 


Gln Gln Leu Thr Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly 
625                 630                 635                 640 


Leu Phe Ala Asn Leu Ser Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu 
                645                 650                 655     


Pro Gly Arg Leu Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn 
            660                 665                 670         


Phe Gly Gln Gly Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His 
        675                 680                 685             


Leu Ile Ile Leu Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn 
    690                 695                 700                 


Lys Asp Thr Ala Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys 
705                 710                 715                 720 


Met Thr Cys Gln Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg 
                725                 730                 735     


Asn Ile Val Lys Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr 
            740                 745                 750         


Phe Cys Gly Cys Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala 
        755                 760                 765             


Ser Asp Arg Gly Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly 
    770                 775                 780                 


Gly Val Ile Gln His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr 
785                 790                 795                 800 


Leu Phe Tyr Arg Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala 
                805                 810                 815     


Ile Asn Ala Asn Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His 
            820                 825                 830         


Ser Ser Pro Pro Ser His Ser Pro Lys Thr 
        835                 840         


<210>  8825
<211>  4923
<212>  DNA
<213>  Homosapiens

<400>  8825
cccaccttac tttatcggaa cgtgcctaag ctgctgcagc tggcacccgg ttgcgctcgg     60

cgaagagggc tgggggcggg agatgacggt ggtcttctcc ctgcttggca ccctgcgagc    120

accagctccc ttctcctcgc cactccaagg ttgcagacga agcaggtact gtcctagatg    180

ttaaggacac aacattgagc aaaaacatgc atagtccctg cttccgtgac acttgagtga    240

actgaatgtg caaagtccct gtggcacaaa gtccctgggg ccagtgtgtg tggcgggtgt    300

agaaggagct aaagagatct ggttggagtt ggagggtgag agaaaatgaa ttctaattta    360

cctgcagaga acttaaccat tgcagtcaat atgaccaaga ctttgcctac agcagtaacg    420

catggattta attccactaa tgacccacct tcaatgtcaa ttacaaggct ttttccagcc    480

ttactggaat gctttggcat tgtcctttgt ggctacatag caggaagggc caatgtcata    540

acatcaaccc aggccaaagg actaggaaat tttgtctcca gatttgcact tccagcttta    600

ttattcaaaa acatggttgt acttaatttt tccaatgtgg actggtcctt cctatatagt    660

atcttaattg ccaaagcttc tgtatttttc attgtatgtg tattaacctt attggttgcc    720

agtcctgata gtcgatttag caaagctgga ctattcccta tttttgctac acaaagtaat    780

gactttgcat tgggataccc tatagttgaa gctttatatc aaactacata cccagaatat    840

ctccagtaca tttatttggt ggcaccaata tctcttatga tgttaaaccc tatagggttt    900

attttctgtg aaatccaaaa gtggaaagac actcaaaatg cttctcaaaa taaaataaaa    960

attgtgggac tcggactcct gcgtgtatta cagaacccaa tagtatttat ggtcttcatt   1020

ggcatcgcct tcaattttat tcttgatcga aaggtacctg tatatgtcga aaattttctt   1080

gatggacttg gaaattcttt ttctggatca gccctatttt atcttggtct cacgatggtg   1140

ggaaaaataa agagactgaa gaagtcggca tttgtagtac taattcttct catcacagct   1200

aaacttctgg tgctgccact tctgtgcaga gaaatggtgg aactcttgga caagggcgac   1260

agtgtggtga accatacaag tttatcaaat tatgcatttc tgtatggtgt atttcctgta   1320

gcaccaggag tggctatctt tgcaacacaa ttcaacatgg aagtagaaat tataacctca   1380

gggatggtga taagcacatt tgtgtctgct cccatcatgt acgtttctgc ctggttactg   1440

acctttccca ctatggaccc taagccattg gcatatgcca tccagaatgt tagttttgat   1500

ataagtattg tcagcctgat ctccttgatc tggtctctgg ctattcttct tttgagtaag   1560

aaatataaac agcttcctca tatgcttaca actaatttac tcattgctca gtctattgtc   1620

tgtgctggaa tgatgatatg gaattttgtt aaagaaaaaa attttgttgg acaaattttg   1680

gtgtttgttc tattgtacag ctccctctat agcacctacc tgtggacagg ccttctagca   1740

atttctttgt ttcttttgaa aaagcgagag agggtacaaa ttcctgttgg aataatcata   1800

atatctggct ggggaattcc tgctctcctt gttggtgttc ttttgataac tggaaaacac   1860

aatggagata gcattgactc agccttcttt tatggaaaag aacagatgat caccacagca   1920

gtcaccctgt tctgcagcat cctgatagct ggcatatccc tcatgtgcat gaaccagact   1980

gcccaagcag gaagctatga aggtttcgat cagtctcaga gccacaaagt ggtggagcct   2040

ggaaatactg cttttgagga gagtccagca ccagtaaatg aaccagaact ttttacaagc   2100

tctattccag aaacaagttg ctgctcctgc tccatgggaa atggtgaatt acactgccca   2160

tcaatagagc caatagcaaa cacaagcacc agtgagcctg tgattccttc gtttgagaaa   2220

aacaatcatt gtgtgagtcg ctgtaactcc cagagctgca tattagccca ggaagaagaa   2280

cagtatctac agagtggaga ccagcaactg acccgacatg tgttgctgtg tttacttctc   2340

atcattggcc tgttcgctaa tctttccagt tgtttatggt ggctattcaa ccaagagcct   2400

ggaagacttt atgttgagtt acagtttttc tgtgccgtgt ttaactttgg tcagggattt   2460

atttcctttg gaatctttgg attagataaa catttaatca tcctgccttt caaaagaaga   2520

cttgaattcc tatggaacaa taaagacaca gcagaaaaca gggattctcc tgtttcagag   2580

gaaataaaaa tgacctgtca acaatttatc cattatcacc gtgacctctg tatccgaaac   2640

attgtcaaag aaagaaggtg tggtgcaaag acttctgctg gaactttctg tggctgtgac   2700

ctggtgagct ggctaattga agtcggcctt gcctccgacc gtggtgaagc tgtgatatac   2760

ggagacaggc tggtacaagg gggagtcatc caacatatta ccaacgagta tgaattccgg   2820

gatgagtact tgttttacag atttcttcaa aagagtcctg aacagagtcc tcctgctatt   2880

aatgcaaaca ctctccaaca ggaaagatat aaagaaattg agcattcatc cccaccctca   2940

cattccccta agacctaaat tatgcagggg agaaccctac atggaatcat attctagccg   3000

cgtattcatt agtttttagc tgggtgacct tgggcaagtt aacagaggca acctctctga   3060

gcctcagttg tctcttctgt aaaatgtgaa aagatgtgct cccaccacat gcgcagggtc   3120

tgtgatttta catgtatgta aaacacatag gaagctgact taggaaaaag agaaaaccaa   3180

attaaagttc tgataatgaa tataatatag tcatccttta gtatccaagg ggattggttc   3240

caggactcct gaagatccca aaatctgagg atactcaagt cccttatata aaatggtgta   3300

ggccgggcat ggtggctcac gcctgtaatc ccagtacttt gggaggccga gtcaggtgga   3360

tcacctgagg tcaggagttc aagaccagcc tggccaacat ggcgaaaccc cgtctctact   3420

ataaaataca aaaaattagt tgggtgtggt ggcgggtgcc tgtaatccca gctactcagg   3480

aggctgaggc aggagaatcg cttgaatctg ggaggcagag gttgctgtga gccgagatcg   3540

tgccactgca ctccagcctg agcaacagag caagactcta tctcaaaaat aaaataaaat   3600

aaaataaaat aattaataaa atggtgtagt atttgcatat aacctatgca cattctccca   3660

tatagtttaa tcatctttag atacttataa tgcctaatac aatgtaaatg ctatgtaaat   3720

agttgttgtt atactgtatt gtttagggaa taacaataag aaaaacagtc tgtacatgtt   3780

cactacagat gcaaccattg ttaagcctga ctacatcttt ttatctgcgg ttgattgaat   3840

ctatggatgt ggaacctgtg catatggagg gtcaactgta ctataaataa tacgaatatg   3900

ccaacattat ataatcattg ctttctgcaa ctgtttacta taatttcaaa attaatatcc   3960

tattaactgt tcctataaat tatcaaattt ggcaagtgta ttactagcag gagatggacc   4020

ttaaattatg acaactttat attttttgat agcatctctt gaaaaagaat tttaatgatt   4080

ctaataagag gttctttttc ttttttccat ttccttgaca aatagtactc atttaaaaac   4140

tagagggcta ggcttagtgg ctcacgcctg taatctcagc actttgggag gctgaggcgg   4200

gcagatcgct tgaggtcagg agttcaagac cagcccgggc aacgtggtga aacccggtct   4260

gtactaaaaa aaaaaaaaaa gaaaaagaaa aagaaaaaag aatacccagg tgtggtagtg   4320

catgcctgta gtcccagcta ctttggagac tgaggtggga gtaccccttg agcctgggag   4380

gcgcaggttg cagtgaacca agatcacatc actgcacttc aacctgggtg acagagcaag   4440

accctgtctc aaaaacaaaa aacaagcaaa aaaaacctag aggcactatt tttttttaaa   4500

gtttgtcttt tcttttctac ccaaattact aatctatgcc attaaggaaa ggaataagaa   4560

cctccatatg tattattatc tccacagtcc tgcagaagta caatctgatc tttaactttc   4620

atgctacaaa taataatttg agtagattaa tttgaatttt atcaacaaaa ttattgccat   4680

atgatgtatc atttctgtgt ttgaacaaag catcgtaatg caggataact tctactttat   4740

tccctgtagt taaaaaaaaa aaaactatat agttcaagcc aatatttaaa aattctaaac   4800

ctaggctggg catggtgact catacctgta atcccagcac tttgggaggc cgaggcaggt   4860

gaattgcttc agcccaggag ttcgagacca gcctggccaa tgtggtgaaa ccccatctct   4920

act                                                                 4923


<210>  8826
<211>  870
<212>  PRT
<213>  Homosapiens

<400>  8826

Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met 
1               5                   10                  15      


Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn 
            20                  25                  30          


Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu 
        35                  40                  45              


Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val 
    50                  55                  60                  


Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser 
                85                  90                  95      


Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser 
            100                 105                 110         


Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp 
        115                 120                 125             


Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser 
    130                 135                 140                 


Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr 
145                 150                 155                 160 


Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser 
                165                 170                 175     


Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys 
            180                 185                 190         


Trp Lys Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly 
        195                 200                 205             


Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe 
    210                 215                 220                 


Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr 
225                 230                 235                 240 


Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala 
                245                 250                 255     


Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys 
            260                 265                 270         


Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu 
        275                 280                 285             


Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly 
    290                 295                 300                 


Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr 
305                 310                 315                 320 


Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe 
                325                 330                 335     


Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe 
            340                 345                 350         


Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro 
        355                 360                 365             


Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe 
    370                 375                 380                 


Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ile Trp Ser Leu Ala Ile 
385                 390                 395                 400 


Leu Leu Leu Ser Lys Lys Tyr Lys Gln Leu Pro His Met Leu Thr Thr 
                405                 410                 415     


Asn Leu Leu Ile Ala Gln Ser Ile Val Cys Ala Gly Met Met Ile Trp 
            420                 425                 430         


Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile Leu Val Phe Val 
        435                 440                 445             


Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Trp Thr Gly Leu Leu 
    450                 455                 460                 


Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg Val Gln Ile Pro 
465                 470                 475                 480 


Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro Ala Leu Leu Val 
                485                 490                 495     


Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp Ser Ile Asp Ser 
            500                 505                 510         


Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr Ala Val Thr Leu 
        515                 520                 525             


Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met Cys Met Asn Gln 
    530                 535                 540                 


Thr Ala Gln Ala Gly Ser Tyr Glu Gly Phe Asp Gln Ser Gln Ser His 
545                 550                 555                 560 


Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu Ser Pro Ala Pro 
                565                 570                 575     


Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro Glu Thr Ser Cys 
            580                 585                 590         


Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys Pro Ser Ile Glu 
        595                 600                 605             


Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile Pro Ser Phe Glu 
    610                 615                 620                 


Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln Ser Cys Ile Leu 
625                 630                 635                 640 


Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp Gln Gln Leu Thr 
                645                 650                 655     


Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly Leu Phe Ala Asn 
            660                 665                 670         


Leu Ser Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu Pro Gly Arg Leu 
        675                 680                 685             


Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn Phe Gly Gln Gly 
    690                 695                 700                 


Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His Leu Ile Ile Leu 
705                 710                 715                 720 


Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn Lys Asp Thr Ala 
                725                 730                 735     


Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys Met Thr Cys Gln 
            740                 745                 750         


Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg Asn Ile Val Lys 
        755                 760                 765             


Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr Phe Cys Gly Cys 
    770                 775                 780                 


Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala Ser Asp Arg Gly 
785                 790                 795                 800 


Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly Gly Val Ile Gln 
                805                 810                 815     


His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr Leu Phe Tyr Arg 
            820                 825                 830         


Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala Ile Asn Ala Asn 
        835                 840                 845             


Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His Ser Ser Pro Pro 
    850                 855                 860                 


Ser His Ser Pro Lys Thr 
865                 870 


<210>  8827
<211>  4817
<212>  DNA
<213>  Homosapiens

<400>  8827
gcggccggcg aggggctgag ctgacagggc cgcatcggct taccccacct tactttatcg     60

gaacgtgcct aagctgctgc agctggcacc cggttgcgct cggcgaagag ggctgggggc    120

gggagatgac ggtggtcttc tccctgcttg gcaccctgcg agcaccagct cccttctcct    180

cgccactcca aggttgcaga cgaagcagag atctggttgg agttggaggg tgagagaaaa    240

tgaattctaa tttacctgca gagaacttaa ccattgcagt caatatgacc aagactttgc    300

ctacagcagt aacgcatgga tttaattcca ctaatgaccc accttcaatg tcaattacaa    360

ggctttttcc agccttactg gaatgctttg gcattgtcct ttgtggctac atagcaggaa    420

gggccaatgt cataacatca acccaggcca aaggactagg aaattttgtc tccagatttg    480

cacttccagc tttattattc aaaaacatgg ttgtacttaa tttttccaat gtggactggt    540

ccttcctata tagtatctta attgccaaag cttctgtatt tttcattgta tgtgtattaa    600

ccttattggt tgccagtcct gatagtcgat ttagcaaagc tggactattc cctatttttg    660

ctacacaaag taatgacttt gcattgggat accctatagt tgaagcttta tatcaaacta    720

catacccaga atatctccag tacatttatt tggtggcacc aatatctctt atgatgttaa    780

accctatagg gtttattttc tgtgaaatcc aaaagtggaa agacactcaa aatgcttctc    840

aaaataaaat aaaaattgtg ggactcggac tcctgcgtgt attacagaac ccaatagtat    900

ttatggtctt cattggcatc gccttcaatt ttattcttga tcgaaaggta cctgtatatg    960

tcgaaaattt tcttgatgga cttggaaatt ctttttctgg atcagcccta ttttatcttg   1020

gtctcacgat ggtgggaaaa ataaagagac tgaagaagtc ggcatttgta gtactaattc   1080

ttctcatcac agctaaactt ctggtgctgc cacttctgtg cagagaaatg gtggaactct   1140

tggacaaggg cgacagtgtg gtgaaccata caagtttatc aaattatgca tttctgtatg   1200

gtgtatttcc tgtagcacca ggagtggcta tctttgcaac acaattcaac atggaagtag   1260

aaattataac ctcagggatg gtgataagca catttgtgtc tgctcccatc atgtacgttt   1320

ctgcctggtt actgaccttt cccactatgg accctaagcc attggcatat gccatccaga   1380

atgttagttt tgatataagt attgtcagcc tgatctcctt gatctggtct ctggctattc   1440

ttcttttgag taagaaatat aaacagcttc ctcatatgct tacaactaat ttactcattg   1500

ctcagtctat tgtctgtgct ggaatgatga tatggaattt tgttaaagaa aaaaattttg   1560

ttggacaaat tttggtgttt gttctattgt acagctccct ctatagcacc tacctgtgga   1620

caggccttct agcaatttct ttgtttcttt tgaaaaagcg agagagggta caaattcctg   1680

ttggaataat cataatatct ggctggggaa ttcctgctct ccttgttggt gttcttttga   1740

taactggaaa acacaatgga gatagcattg actcagcctt cttttatgga aaagaacaga   1800

tgatcaccac agcagtcacc ctgttctgca gcatcctgat agctggcata tccctcatgt   1860

gcatgaacca gactgcccaa gcaggaagct atgaaggttt cgatcagtct cagagccaca   1920

aagtggtgga gcctggaaat actgcttttg aggagagtcc agcaccagta aatgaaccag   1980

aactttttac aagctctatt ccagaaacaa gttgctgctc ctgctccatg ggaaatggtg   2040

aattacactg cccatcaata gagccaatag caaacacaag caccagtgag cctgtgattc   2100

cttcgtttga gaaaaacaat cattgtgtga gtcgctgtaa ctcccagagc tgcatattag   2160

cccaggaaga agaacagtat ctacagagtg gagaccagca actgacccga catgtgttgc   2220

tgtgtttact tctcatcatt ggcctgttcg ctaatctttc cagttgttta tggtggctat   2280

tcaaccaaga gcctggaaga ctttatgttg agttacagtt tttctgtgcc gtgtttaact   2340

ttggtcaggg atttatttcc tttggaatct ttggattaga taaacattta atcatcctgc   2400

ctttcaaaag aagacttgaa ttcctatgga acaataaaga cacagcagaa aacagggatt   2460

ctcctgtttc agaggaaata aaaatgacct gtcaacaatt tatccattat caccgtgacc   2520

tctgtatccg aaacattgtc aaagaaagaa ggtgtggtgc aaagacttct gctggaactt   2580

tctgtggctg tgacctggtg agctggctaa ttgaagtcgg ccttgcctcc gaccgtggtg   2640

aagctgtgat atacggagac aggctggtac aagggggagt catccaacat attaccaacg   2700

agtatgaatt ccgggatgag tacttgtttt acagatttct tcaaaagagt cctgaacaga   2760

gtcctcctgc tattaatgca aacactctcc aacaggaaag atataaagaa attgagcatt   2820

catccccacc ctcacattcc cctaagacct aaattatgca ggggagaacc ctacatggaa   2880

tcatattcta gccgcgtatt cattagtttt tagctgggtg accttgggca agttaacaga   2940

ggcaacctct ctgagcctca gttgtctctt ctgtaaaatg tgaaaagatg tgctcccacc   3000

acatgcgcag ggtctgtgat tttacatgta tgtaaaacac ataggaagct gacttaggaa   3060

aaagagaaaa ccaaattaaa gttctgataa tgaatataat atagtcatcc tttagtatcc   3120

aaggggattg gttccaggac tcctgaagat cccaaaatct gaggatactc aagtccctta   3180

tataaaatgg tgtaggccgg gcatggtggc tcacgcctgt aatcccagta ctttgggagg   3240

ccgagtcagg tggatcacct gaggtcagga gttcaagacc agcctggcca acatggcgaa   3300

accccgtctc tactataaaa tacaaaaaat tagttgggtg tggtggcggg tgcctgtaat   3360

cccagctact caggaggctg aggcaggaga atcgcttgaa tctgggaggc agaggttgct   3420

gtgagccgag atcgtgccac tgcactccag cctgagcaac agagcaagac tctatctcaa   3480

aaataaaata aaataaaata aaataattaa taaaatggtg tagtatttgc atataaccta   3540

tgcacattct cccatatagt ttaatcatct ttagatactt ataatgccta atacaatgta   3600

aatgctatgt aaatagttgt tgttatactg tattgtttag ggaataacaa taagaaaaac   3660

agtctgtaca tgttcactac agatgcaacc attgttaagc ctgactacat ctttttatct   3720

gcggttgatt gaatctatgg atgtggaacc tgtgcatatg gagggtcaac tgtactataa   3780

ataatacgaa tatgccaaca ttatataatc attgctttct gcaactgttt actataattt   3840

caaaattaat atcctattaa ctgttcctat aaattatcaa atttggcaag tgtattacta   3900

gcaggagatg gaccttaaat tatgacaact ttatattttt tgatagcatc tcttgaaaaa   3960

gaattttaat gattctaata agaggttctt tttctttttt ccatttcctt gacaaatagt   4020

actcatttaa aaactagagg gctaggctta gtggctcacg cctgtaatct cagcactttg   4080

ggaggctgag gcgggcagat cgcttgaggt caggagttca agaccagccc gggcaacgtg   4140

gtgaaacccg gtctgtacta aaaaaaaaaa aaaagaaaaa gaaaaagaaa aaagaatacc   4200

caggtgtggt agtgcatgcc tgtagtccca gctactttgg agactgaggt gggagtaccc   4260

cttgagcctg ggaggcgcag gttgcagtga accaagatca catcactgca cttcaacctg   4320

ggtgacagag caagaccctg tctcaaaaac aaaaaacaag caaaaaaaac ctagaggcac   4380

tatttttttt taaagtttgt cttttctttt ctacccaaat tactaatcta tgccattaag   4440

gaaaggaata agaacctcca tatgtattat tatctccaca gtcctgcaga agtacaatct   4500

gatctttaac tttcatgcta caaataataa tttgagtaga ttaatttgaa ttttatcaac   4560

aaaattattg ccatatgatg tatcatttct gtgtttgaac aaagcatcgt aatgcaggat   4620

aacttctact ttattccctg tagttaaaaa aaaaaaaact atatagttca agccaatatt   4680

taaaaattct aaacctaggc tgggcatggt gactcatacc tgtaatccca gcactttggg   4740

aggccgaggc aggtgaattg cttcagccca ggagttcgag accagcctgg ccaatgtggt   4800

gaaaccccat ctctact                                                  4817


<210>  8828
<211>  870
<212>  PRT
<213>  Homosapiens

<400>  8828

Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met 
1               5                   10                  15      


Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn 
            20                  25                  30          


Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu 
        35                  40                  45              


Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val 
    50                  55                  60                  


Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser 
                85                  90                  95      


Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser 
            100                 105                 110         


Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp 
        115                 120                 125             


Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser 
    130                 135                 140                 


Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr 
145                 150                 155                 160 


Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser 
                165                 170                 175     


Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys 
            180                 185                 190         


Trp Lys Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly 
        195                 200                 205             


Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe 
    210                 215                 220                 


Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr 
225                 230                 235                 240 


Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala 
                245                 250                 255     


Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys 
            260                 265                 270         


Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu 
        275                 280                 285             


Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly 
    290                 295                 300                 


Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr 
305                 310                 315                 320 


Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe 
                325                 330                 335     


Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe 
            340                 345                 350         


Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro 
        355                 360                 365             


Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe 
    370                 375                 380                 


Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ile Trp Ser Leu Ala Ile 
385                 390                 395                 400 


Leu Leu Leu Ser Lys Lys Tyr Lys Gln Leu Pro His Met Leu Thr Thr 
                405                 410                 415     


Asn Leu Leu Ile Ala Gln Ser Ile Val Cys Ala Gly Met Met Ile Trp 
            420                 425                 430         


Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile Leu Val Phe Val 
        435                 440                 445             


Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Trp Thr Gly Leu Leu 
    450                 455                 460                 


Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg Val Gln Ile Pro 
465                 470                 475                 480 


Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro Ala Leu Leu Val 
                485                 490                 495     


Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp Ser Ile Asp Ser 
            500                 505                 510         


Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr Ala Val Thr Leu 
        515                 520                 525             


Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met Cys Met Asn Gln 
    530                 535                 540                 


Thr Ala Gln Ala Gly Ser Tyr Glu Gly Phe Asp Gln Ser Gln Ser His 
545                 550                 555                 560 


Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu Ser Pro Ala Pro 
                565                 570                 575     


Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro Glu Thr Ser Cys 
            580                 585                 590         


Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys Pro Ser Ile Glu 
        595                 600                 605             


Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile Pro Ser Phe Glu 
    610                 615                 620                 


Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln Ser Cys Ile Leu 
625                 630                 635                 640 


Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp Gln Gln Leu Thr 
                645                 650                 655     


Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly Leu Phe Ala Asn 
            660                 665                 670         


Leu Ser Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu Pro Gly Arg Leu 
        675                 680                 685             


Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn Phe Gly Gln Gly 
    690                 695                 700                 


Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His Leu Ile Ile Leu 
705                 710                 715                 720 


Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn Lys Asp Thr Ala 
                725                 730                 735     


Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys Met Thr Cys Gln 
            740                 745                 750         


Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg Asn Ile Val Lys 
        755                 760                 765             


Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr Phe Cys Gly Cys 
    770                 775                 780                 


Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala Ser Asp Arg Gly 
785                 790                 795                 800 


Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly Gly Val Ile Gln 
                805                 810                 815     


His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr Leu Phe Tyr Arg 
            820                 825                 830         


Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala Ile Asn Ala Asn 
        835                 840                 845             


Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His Ser Ser Pro Pro 
    850                 855                 860                 


Ser His Ser Pro Lys Thr 
865                 870 


<210>  8829
<211>  4898
<212>  DNA
<213>  Homosapiens

<400>  8829
agcggggcct gaaggcgggg cgggggcggg gcctcgcggc cggcgagggg ctgagctgac     60

agggccgcat cggcttaccc caccttactt tatcggaacg tgcctaagct gctgcagctg    120

gcacccggtt gcgctcggcg aagagggctg ggggcgggag atgacggtgg tcttctccct    180

gcttggcacc ctgcgagcac cagctccctt ctcctcgcca ctccaaggtt gcagacgaag    240

cagatgtgat tataaagact tcagtggaat aatcgcaagt tcccatgtga gatctggttg    300

gagttggagg gtgagagaaa atgaattcta atttacctgc agagaactta accattgcag    360

tcaatatgac caagactttg cctacagcag taacgcatgg atttaattcc actaatgacc    420

caccttcaat gtcaattaca aggctttttc cagccttact ggaatgcttt ggcattgtcc    480

tttgtggcta catagcagga agggccaatg tcataacatc aacccaggcc aaaggactag    540

gaaattttgt ctccagattt gcacttccag ctttattatt caaaaacatg gttgtactta    600

atttttccaa tgtggactgg tccttcctat atagtatctt aattgccaaa gcttctgtat    660

ttttcattgt atgtgtatta accttattgg ttgccagtcc tgatagtcga tttagcaaag    720

ctggactatt ccctattttt gctacacaaa gtaatgactt tgcattggga taccctatag    780

ttgaagcttt atatcaaact acatacccag aatatctcca gtacatttat ttggtggcac    840

caatatctct tatgatgtta aaccctatag ggtttatttt ctgtgaaatc caaaagtgga    900

aagacactca aaatgcttct caaaataaaa taaaaattgt gggactcgga ctcctgcgtg    960

tattacagaa cccaatagta tttatggtct tcattggcat cgccttcaat tttattcttg   1020

atcgaaaggt acctgtatat gtcgaaaatt ttcttgatgg acttggaaat tctttttctg   1080

gatcagccct attttatctt ggtctcacga tggtgggaaa aataaagaga ctgaagaagt   1140

cggcatttgt agtactaatt cttctcatca cagctaaact tctggtgctg ccacttctgt   1200

gcagagaaat ggtggaactc ttggacaagg gcgacagtgt ggtgaaccat acaagtttat   1260

caaattatgc atttctgtat ggtgtatttc ctgtagcacc aggagtggct atctttgcaa   1320

cacaattcaa catggaagta gaaattataa cctcagggat ggtgataagc acatttgtgt   1380

ctgctcccat catgtacgtt tctgcctggt tactgacctt tcccactatg gaccctaagc   1440

cattggcata tgccatccag aatgttagtt ttgatataag tattgtcagc ctgatctcct   1500

tgatctggtc tctggctatt cttcttttga gtaagaaata taaacagctt cctcatatgc   1560

ttacaactaa tttactcatt gctcagtcta ttgtctgtgc tggaatgatg atatggaatt   1620

ttgttaaaga aaaaaatttt gttggacaaa ttttggtgtt tgttctattg tacagctccc   1680

tctatagcac ctacctgtgg acaggccttc tagcaatttc tttgtttctt ttgaaaaagc   1740

gagagagggt acaaattcct gttggaataa tcataatatc tggctgggga attcctgctc   1800

tccttgttgg tgttcttttg ataactggaa aacacaatgg agatagcatt gactcagcct   1860

tcttttatgg aaaagaacag atgatcacca cagcagtcac cctgttctgc agcatcctga   1920

tagctggcat atccctcatg tgcatgaacc agactgccca agcaggaagc tatgaaggtt   1980

tcgatcagtc tcagagccac aaagtggtgg agcctggaaa tactgctttt gaggagagtc   2040

cagcaccagt aaatgaacca gaacttttta caagctctat tccagaaaca agttgctgct   2100

cctgctccat gggaaatggt gaattacact gcccatcaat agagccaata gcaaacacaa   2160

gcaccagtga gcctgtgatt ccttcgtttg agaaaaacaa tcattgtgtg agtcgctgta   2220

actcccagag ctgcatatta gcccaggaag aagaacagta tctacagagt ggagaccagc   2280

aactgacccg acatgtgttg ctgtgtttac ttctcatcat tggcctgttc gctaatcttt   2340

ccagttgttt atggtggcta ttcaaccaag agcctggaag actttatgtt gagttacagt   2400

ttttctgtgc cgtgtttaac tttggtcagg gatttatttc ctttggaatc tttggattag   2460

ataaacattt aatcatcctg cctttcaaaa gaagacttga attcctatgg aacaataaag   2520

acacagcaga aaacagggat tctcctgttt cagaggaaat aaaaatgacc tgtcaacaat   2580

ttatccatta tcaccgtgac ctctgtatcc gaaacattgt caaagaaaga aggtgtggtg   2640

caaagacttc tgctggaact ttctgtggct gtgacctggt gagctggcta attgaagtcg   2700

gccttgcctc cgaccgtggt gaagctgtga tatacggaga caggctggta caagggggag   2760

tcatccaaca tattaccaac gagtatgaat tccgggatga gtacttgttt tacagatttc   2820

ttcaaaagag tcctgaacag agtcctcctg ctattaatgc aaacactctc caacaggaaa   2880

gatataaaga aattgagcat tcatccccac cctcacattc ccctaagacc taaattatgc   2940

aggggagaac cctacatgga atcatattct agccgcgtat tcattagttt ttagctgggt   3000

gaccttgggc aagttaacag aggcaacctc tctgagcctc agttgtctct tctgtaaaat   3060

gtgaaaagat gtgctcccac cacatgcgca gggtctgtga ttttacatgt atgtaaaaca   3120

cataggaagc tgacttagga aaaagagaaa accaaattaa agttctgata atgaatataa   3180

tatagtcatc ctttagtatc caaggggatt ggttccagga ctcctgaaga tcccaaaatc   3240

tgaggatact caagtccctt atataaaatg gtgtaggccg ggcatggtgg ctcacgcctg   3300

taatcccagt actttgggag gccgagtcag gtggatcacc tgaggtcagg agttcaagac   3360

cagcctggcc aacatggcga aaccccgtct ctactataaa atacaaaaaa ttagttgggt   3420

gtggtggcgg gtgcctgtaa tcccagctac tcaggaggct gaggcaggag aatcgcttga   3480

atctgggagg cagaggttgc tgtgagccga gatcgtgcca ctgcactcca gcctgagcaa   3540

cagagcaaga ctctatctca aaaataaaat aaaataaaat aaaataatta ataaaatggt   3600

gtagtatttg catataacct atgcacattc tcccatatag tttaatcatc tttagatact   3660

tataatgcct aatacaatgt aaatgctatg taaatagttg ttgttatact gtattgttta   3720

gggaataaca ataagaaaaa cagtctgtac atgttcacta cagatgcaac cattgttaag   3780

cctgactaca tctttttatc tgcggttgat tgaatctatg gatgtggaac ctgtgcatat   3840

ggagggtcaa ctgtactata aataatacga atatgccaac attatataat cattgctttc   3900

tgcaactgtt tactataatt tcaaaattaa tatcctatta actgttccta taaattatca   3960

aatttggcaa gtgtattact agcaggagat ggaccttaaa ttatgacaac tttatatttt   4020

ttgatagcat ctcttgaaaa agaattttaa tgattctaat aagaggttct ttttcttttt   4080

tccatttcct tgacaaatag tactcattta aaaactagag ggctaggctt agtggctcac   4140

gcctgtaatc tcagcacttt gggaggctga ggcgggcaga tcgcttgagg tcaggagttc   4200

aagaccagcc cgggcaacgt ggtgaaaccc ggtctgtact aaaaaaaaaa aaaaagaaaa   4260

agaaaaagaa aaaagaatac ccaggtgtgg tagtgcatgc ctgtagtccc agctactttg   4320

gagactgagg tgggagtacc ccttgagcct gggaggcgca ggttgcagtg aaccaagatc   4380

acatcactgc acttcaacct gggtgacaga gcaagaccct gtctcaaaaa caaaaaacaa   4440

gcaaaaaaaa cctagaggca ctattttttt ttaaagtttg tcttttcttt tctacccaaa   4500

ttactaatct atgccattaa ggaaaggaat aagaacctcc atatgtatta ttatctccac   4560

agtcctgcag aagtacaatc tgatctttaa ctttcatgct acaaataata atttgagtag   4620

attaatttga attttatcaa caaaattatt gccatatgat gtatcatttc tgtgtttgaa   4680

caaagcatcg taatgcagga taacttctac tttattccct gtagttaaaa aaaaaaaaac   4740

tatatagttc aagccaatat ttaaaaattc taaacctagg ctgggcatgg tgactcatac   4800

ctgtaatccc agcactttgg gaggccgagg caggtgaatt gcttcagccc aggagttcga   4860

gaccagcctg gccaatgtgg tgaaacccca tctctact                           4898


<210>  8830
<211>  870
<212>  PRT
<213>  Homosapiens

<400>  8830

Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met 
1               5                   10                  15      


Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn 
            20                  25                  30          


Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu 
        35                  40                  45              


Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val 
    50                  55                  60                  


Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser 
                85                  90                  95      


Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser 
            100                 105                 110         


Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp 
        115                 120                 125             


Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser 
    130                 135                 140                 


Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr 
145                 150                 155                 160 


Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser 
                165                 170                 175     


Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys 
            180                 185                 190         


Trp Lys Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly 
        195                 200                 205             


Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe 
    210                 215                 220                 


Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr 
225                 230                 235                 240 


Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala 
                245                 250                 255     


Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys 
            260                 265                 270         


Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu 
        275                 280                 285             


Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly 
    290                 295                 300                 


Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr 
305                 310                 315                 320 


Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe 
                325                 330                 335     


Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe 
            340                 345                 350         


Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro 
        355                 360                 365             


Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe 
    370                 375                 380                 


Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ile Trp Ser Leu Ala Ile 
385                 390                 395                 400 


Leu Leu Leu Ser Lys Lys Tyr Lys Gln Leu Pro His Met Leu Thr Thr 
                405                 410                 415     


Asn Leu Leu Ile Ala Gln Ser Ile Val Cys Ala Gly Met Met Ile Trp 
            420                 425                 430         


Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile Leu Val Phe Val 
        435                 440                 445             


Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Trp Thr Gly Leu Leu 
    450                 455                 460                 


Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg Val Gln Ile Pro 
465                 470                 475                 480 


Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro Ala Leu Leu Val 
                485                 490                 495     


Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp Ser Ile Asp Ser 
            500                 505                 510         


Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr Ala Val Thr Leu 
        515                 520                 525             


Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met Cys Met Asn Gln 
    530                 535                 540                 


Thr Ala Gln Ala Gly Ser Tyr Glu Gly Phe Asp Gln Ser Gln Ser His 
545                 550                 555                 560 


Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu Ser Pro Ala Pro 
                565                 570                 575     


Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro Glu Thr Ser Cys 
            580                 585                 590         


Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys Pro Ser Ile Glu 
        595                 600                 605             


Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile Pro Ser Phe Glu 
    610                 615                 620                 


Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln Ser Cys Ile Leu 
625                 630                 635                 640 


Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp Gln Gln Leu Thr 
                645                 650                 655     


Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly Leu Phe Ala Asn 
            660                 665                 670         


Leu Ser Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu Pro Gly Arg Leu 
        675                 680                 685             


Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn Phe Gly Gln Gly 
    690                 695                 700                 


Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His Leu Ile Ile Leu 
705                 710                 715                 720 


Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn Lys Asp Thr Ala 
                725                 730                 735     


Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys Met Thr Cys Gln 
            740                 745                 750         


Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg Asn Ile Val Lys 
        755                 760                 765             


Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr Phe Cys Gly Cys 
    770                 775                 780                 


Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala Ser Asp Arg Gly 
785                 790                 795                 800 


Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly Gly Val Ile Gln 
                805                 810                 815     


His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr Leu Phe Tyr Arg 
            820                 825                 830         


Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala Ile Asn Ala Asn 
        835                 840                 845             


Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His Ser Ser Pro Pro 
    850                 855                 860                 


Ser His Ser Pro Lys Thr 
865                 870 


<210>  8831
<211>  3928
<212>  DNA
<213>  Homosapiens

<400>  8831
cccaccttac tttatcggaa cgtgcctaag ctgctgcagc tggcacccgg ttgcgctcgg     60

cgaagagggc tgggggcggg agatgacggt ggtcttctcc ctgcttggca ccctgcgagc    120

accagctccc ttctcctcgc cactccaagg ttgcagacga agcaggtact gtcctagatg    180

ttaaggacac aacattgagc aaaaacatgc atagtccctg cttccgtgac acttgagtga    240

actgaatgtg caaagtccct gtggcacaaa gtccctgggg ccagtgtgtg tggcgggtgt    300

agaaggagct aaagagatct ggttggagtt ggagggtgag agaaaatgaa ttctaattta    360

cctgcagaga acttaaccat tgcagtcaat atgaccaaga ctttgcctac agcagtaacg    420

catggattta attccactaa tgacccacct tcaatgtcaa ttacaaggct ttttccagcc    480

ttactggaat gctttggcat tgtcctttgt ggctacatag caggaagggc caatgtcata    540

acatcaaccc aggccaaagg actaggaaat tttgtctcca gatttgcact tccagcttta    600

ttattcaaaa acatggttgt acttaatttt tccaatgtgg actggtcctt cctatatagt    660

atcttaattg ccaaagcttc tgtatttttc attgtatgtg tattaacctt attggttgcc    720

agtcctgata gtcgatttag caaagctgga ctattcccta tttttgctac acaaagtaat    780

gactttgcat tgggataccc tatagttgaa gctttatatc aaactacata cccagaatat    840

ctccagtaca tttatttggt ggcaccaata tctcttatga tgttaaaccc tatagggttt    900

attttctgtg aaatccaaaa gtggaaagac actcaaaatg cttctcaaaa taaaataaaa    960

attgtgggac tcggactcct gcgtgtatta cagaacccaa tagtatttat ggtcttcatt   1020

ggcatcgcct tcaattttat tcttgatcga aaggtacctg tatatgtcga aaattttctt   1080

gatggacttg gaaattcttt ttctggatca gccctatttt atcttggtct cacgatggtg   1140

ggaaaaataa agagactgaa gaagtcggca tttgtagtac taattcttct catcacagct   1200

aaacttctgg tgctgccact tctgtgcaga gaaatggtgg aactcttgga caagggcgac   1260

agtgtggtga accatacaag tttatcaaat tatgcatttc tgtatggtgt atttcctgta   1320

gcaccaggag tggctatctt tgcaacacaa ttcaacatgg aagtagaaat tataacctca   1380

gggatggtga taagcacatt tgtgtctgct cccatcatgt acgtttctgc ctggttactg   1440

acctttccca ctatggaccc taagccattg gcatatgcca tccagaatgt tagttttgat   1500

ataagtattg tcagcctgat ctccttgatc tggtctctgg ctattcttct tttgagtaag   1560

aaatataaac agcttcctca tatgcttaca actaatttac tcattgctca gtctattgtc   1620

tgtgctggaa tgatgatatg gaattttgtt aaagaaaaaa attttgttgg acaaattttg   1680

gtgtttgttc tattgtacag ctccctctat agcacctacc tgtggacagg ccttctagca   1740

atttctttgt ttcttttgaa aaagcgagag agggtacaaa ttcctgttgg aataatcata   1800

atatctggct ggggaattcc tgctctcctt gttggtgttc ttttgataac tggaaaacac   1860

aatggagata gcattgactc agccttcttt tatggaaaag aacagatgat caccacagca   1920

gtcaccctgt tctgcagcat cctgatagct ggcatatccc tcatgtgcat gaaccagact   1980

gcccaagcag gaagctatga aggtttcgat cagtctcaga gccacaaagt ggtggagcct   2040

ggaaatactg cttttgagga gagtccagca ccagtaaatg aaccagaact ttttacaagc   2100

tctattccag aaacaagttg ctgctcctgc tccatgggaa atggtgaatt acactgccca   2160

tcaatagagc caatagcaaa cacaagcacc agtgagcctg tgattccttc gtttgagaaa   2220

aacaatcatt gtgtgagtcg ctgtaactcc cagagctgca tattagccca ggaagaagaa   2280

cagtatctac agagtggaga ccagcaactg acccgacatg tgttgctgtg tttacttctc   2340

atcattggcc tgttcgctaa tctttccagt tgtttatggt ggctattcaa ccaagagcct   2400

ggaagacttt atgttgagtt acagtttttc tgtgccgtgt ttaactttgg tcagggattt   2460

atttcctttg gaatctttgg attagataaa catttaatca tcctgccttt caaaagaaga   2520

cttgaattcc tatggaacaa taaagacaca gcagaaaaca gggattctcc tgtttcagag   2580

gaaataaaaa tgacctgtca acaatttatc cattatcacc gtgacctctg tatccgaaac   2640

attgtcaaag aaagaaggtg tggtgcaaag acttctgctg gaactttctg tggctgtgac   2700

ctggtgagct ggctaattga agtcggcctt gcctccgacc gtggtgaagc tgtgatatac   2760

ggagacaggc tggtacaagg gggagtcatc caacatatta ccaacgagta tgaattccgg   2820

gatgagtact tgttttacag atttcttcaa aagagtcctg aacagagtcc tcctgctatt   2880

aatgcaaaca ctctccaaca ggaaagatat aaagaaattg agcattcatc cccaccctca   2940

cattccccta agacctaaat tatgcagggg agaaccctac atggaatcat attctagccg   3000

cgtattcatt agtttttagc tgggtgacct tgggcaagtt aacagaggca acctctctga   3060

gcctcagttg tctcttctgt aaaatgtgaa aagatgtgct cccaccacat gcgcagggtc   3120

tgtgatttta catgtatgta aaacacatag gaagctgact taggaaaaag agaaaaccaa   3180

attaaagttc tgataatgaa tataatatag tcatccttta gtatccaagg ggattggttc   3240

caggactcct gaagatccca aaatctgagg atactcaagt cccttatata aaatggtgta   3300

ggccgggcat ggtggctcac gcctgtaatc ccagtacttt gggaggccga gtcaggtgga   3360

tcacctgagg tcaggagttc aagaccagcc tggccaacat ggcgaaaccc cgtctctact   3420

ataaaataca aaaaattagt tgggtgtggt ggcgggtgcc tgtaatccca gctactcagg   3480

aggctgaggc aggagaatcg cttgaatctg ggaggcagag gttgctgtga gccgagatcg   3540

tgccactgca ctccagcctg agcaacagag caagactcta tctcaaaaat aaaataaaat   3600

aaaataaaat aattaataaa atggtgtagt atttgcatat aacctatgca cattctccca   3660

tatagtttaa tcatctttag atacttataa tgcctaatac aatgtaaatg ctatgtaaat   3720

agttgttgtt atactgtatt gtttagggaa taacaataag aaaaacagtc tgtacatgtt   3780

cactacagat gcaaccattg ttaagcctga ctacatcttt ttatctgcgg ttgattgaat   3840

ctatggatgt ggaacctgtg catatggagg gtcaactgta ctataaataa tacgaatatg   3900

ccaacattat ataatcattg ctttctgc                                      3928


<210>  8832
<211>  870
<212>  PRT
<213>  Homosapiens

<400>  8832

Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met 
1               5                   10                  15      


Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn 
            20                  25                  30          


Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu 
        35                  40                  45              


Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val 
    50                  55                  60                  


Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser 
                85                  90                  95      


Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser 
            100                 105                 110         


Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp 
        115                 120                 125             


Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser 
    130                 135                 140                 


Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr 
145                 150                 155                 160 


Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser 
                165                 170                 175     


Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys 
            180                 185                 190         


Trp Lys Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly 
        195                 200                 205             


Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe 
    210                 215                 220                 


Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr 
225                 230                 235                 240 


Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala 
                245                 250                 255     


Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys 
            260                 265                 270         


Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu 
        275                 280                 285             


Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly 
    290                 295                 300                 


Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr 
305                 310                 315                 320 


Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe 
                325                 330                 335     


Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe 
            340                 345                 350         


Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro 
        355                 360                 365             


Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe 
    370                 375                 380                 


Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ile Trp Ser Leu Ala Ile 
385                 390                 395                 400 


Leu Leu Leu Ser Lys Lys Tyr Lys Gln Leu Pro His Met Leu Thr Thr 
                405                 410                 415     


Asn Leu Leu Ile Ala Gln Ser Ile Val Cys Ala Gly Met Met Ile Trp 
            420                 425                 430         


Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile Leu Val Phe Val 
        435                 440                 445             


Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Trp Thr Gly Leu Leu 
    450                 455                 460                 


Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg Val Gln Ile Pro 
465                 470                 475                 480 


Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro Ala Leu Leu Val 
                485                 490                 495     


Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp Ser Ile Asp Ser 
            500                 505                 510         


Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr Ala Val Thr Leu 
        515                 520                 525             


Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met Cys Met Asn Gln 
    530                 535                 540                 


Thr Ala Gln Ala Gly Ser Tyr Glu Gly Phe Asp Gln Ser Gln Ser His 
545                 550                 555                 560 


Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu Ser Pro Ala Pro 
                565                 570                 575     


Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro Glu Thr Ser Cys 
            580                 585                 590         


Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys Pro Ser Ile Glu 
        595                 600                 605             


Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile Pro Ser Phe Glu 
    610                 615                 620                 


Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln Ser Cys Ile Leu 
625                 630                 635                 640 


Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp Gln Gln Leu Thr 
                645                 650                 655     


Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly Leu Phe Ala Asn 
            660                 665                 670         


Leu Ser Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu Pro Gly Arg Leu 
        675                 680                 685             


Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn Phe Gly Gln Gly 
    690                 695                 700                 


Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His Leu Ile Ile Leu 
705                 710                 715                 720 


Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn Lys Asp Thr Ala 
                725                 730                 735     


Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys Met Thr Cys Gln 
            740                 745                 750         


Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg Asn Ile Val Lys 
        755                 760                 765             


Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr Phe Cys Gly Cys 
    770                 775                 780                 


Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala Ser Asp Arg Gly 
785                 790                 795                 800 


Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly Gly Val Ile Gln 
                805                 810                 815     


His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr Leu Phe Tyr Arg 
            820                 825                 830         


Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala Ile Asn Ala Asn 
        835                 840                 845             


Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His Ser Ser Pro Pro 
    850                 855                 860                 


Ser His Ser Pro Lys Thr 
865                 870 


<210>  8833
<211>  1030
<212>  DNA
<213>  Homosapiens

<400>  8833
cttccggctt ccctgctccc acaaaatggt agccgccgtg ggggatgtcc agtttttttt     60

cctcttccca agtacagacg cagagcagac ttgtctttcc gcttaacctc aacctcgtgt    120

gatctgccag tttcgctccc ggttagccca ggacttttta tagcatagag ttttaaagca    180

agggcttaga atcagacctg ggtcaaaatc ctgccttcca ccttcaccaa ggcagtgtga    240

ccttgacgtt cctacataag agattaaaat gtaaaccctt agccctgagc ttgttttaga    300

atctgggccc cgtccatgac tgcttctatt ctattgcggt acgggggtgg ggtgggggtg    360

gggaactaca tgcatgtcca ctcagtatac tgaaactggt tacattgatg gaaaacttcc    420

aaagcttctt gaaataaaga cgccaaattc cagcgaaaca gctgatgcca gccagcttga    480

agacccctgc cacagaagaa gggaatcagc atgagaatac agcttcttca tctcgctgtc    540

ccatgacttc gccctgtact cttcagccaa ttaatgatct ccacacttgg gaccactcta    600

aaacccttaa gaacctgaga ctcaaagtcc tcctggagac gaatttgagg tttcctccta    660

tctgtgtttg gtggccctat gattaaacct ctttctcttc tgcaacctgg tgtcccagtg    720

tattaacttg ccatgggcat cagacaacaa acctatatat agtatcccaa atatggtgct    780

ccactttgaa acctgaagaa atcctgcaat tgagttagcc ttttgaaata aaaattattt    840

caaattttaa aatatttata tatgtttcca cttaagatat ctacaagcat ttgtttacaa    900

ccttttatct tgctttgcat cttaaacatt tctgtatggc aatttccgtg tcttcctatc    960

atctcggcca tcttagtgca aagatacaaa attgtgtggc ttattaagaa aaattacagt   1020

aagctaaggg                                                          1030


<210>  8834
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  8834

Met Ser Thr Gln Tyr Thr Glu Thr Gly Tyr Ile Asp Gly Lys Leu Pro 
1               5                   10                  15      


Lys Leu Leu Glu Ile Lys Thr Pro Asn Ser Ser Glu Thr Ala Asp Ala 
            20                  25                  30          


Ser Gln Leu Glu Asp Pro Cys His Arg Arg Arg Glu Ser Ala 
        35                  40                  45      


<210>  8835
<211>  391
<212>  DNA
<213>  Homosapiens

<400>  8835
gctcccacaa aatggtagcc gccgtggggg atgtccagtt ttttttcctc ttcccaagta     60

cagacgcaga gcagacttgt ctttccgctt aacctcaacc tcgtgtgatc tgccagtttc    120

gctcccgacg ccaaattcca gcgaaacagc tgatgccagc cagcttgaag acccctgcca    180

cagaagaagg gaatcagcat gagaatacag cttcttcatc tcgctgtccc atgacttcgc    240

cctgtactct tcagccaatt aatgatctcc acacttggga ccactctaaa acccttaaga    300

acctgagact caaagtcctc ctggagacga atttgaggtt tcctcctatc tgtgtttggt    360

ggccctatga ttaaacctct ttctcttctg c                                   391


<210>  8836
<211>  73
<212>  PRT
<213>  Homosapiens

<400>  8836

Met Pro Ala Ser Leu Lys Thr Pro Ala Thr Glu Glu Gly Asn Gln His 
1               5                   10                  15      


Glu Asn Thr Ala Ser Ser Ser Arg Cys Pro Met Thr Ser Pro Cys Thr 
            20                  25                  30          


Leu Gln Pro Ile Asn Asp Leu His Thr Trp Asp His Ser Lys Thr Leu 
        35                  40                  45              


Lys Asn Leu Arg Leu Lys Val Leu Leu Glu Thr Asn Leu Arg Phe Pro 
    50                  55                  60                  


Pro Ile Cys Val Trp Trp Pro Tyr Asp 
65                  70              


<210>  8837
<211>  718
<212>  DNA
<213>  Homosapiens

<400>  8837
gctcccacaa aatggtagcc gccgtggggg atgtccagtt ttttttcctc ttcccaagta     60

cagacgcaga gcagacttgt ctttccgctt aacctcaacc tcgtgtgatc tgccagtttc    120

gctcccgacg ccaaattcca gcgaaacagc tgatgccagc cagcttgaag acccctgcca    180

cagaagaagg gaatcagcat gagaatacag cttcttcatc tcgctgtccc atgacttcgc    240

cctgtactct tcagccaatt aatgatctcc acacttggga ccactctaaa acccttaaga    300

acctgagact caaagtcctc ctggagacga atttgaggtt tcctcctatc tgtgtttggt    360

ggccctatga ttaaacctct ttctcttctg caacctggtg tcccagtgta ttaacttgcc    420

atgggcatca gacaacaaac ctatatatag tatcccaaat atggtgctcc actttgaaac    480

ctgaagaaat cctgcaattg agttagcctt ttgaaataaa aattatttca aattttaaaa    540

tatttatata tgtttccact taagatatct acaagcattt gtttacaacc ttttatcttg    600

ctttgcatct taaacatttc tgtatggcaa tttccgtgtc ttcctatcat ctcggccatc    660

ttagtgcaaa gatacaaaat tgtgtggctt attaagaaaa attacagtaa gctaaggg      718


<210>  8838
<211>  73
<212>  PRT
<213>  Homosapiens

<400>  8838

Met Pro Ala Ser Leu Lys Thr Pro Ala Thr Glu Glu Gly Asn Gln His 
1               5                   10                  15      


Glu Asn Thr Ala Ser Ser Ser Arg Cys Pro Met Thr Ser Pro Cys Thr 
            20                  25                  30          


Leu Gln Pro Ile Asn Asp Leu His Thr Trp Asp His Ser Lys Thr Leu 
        35                  40                  45              


Lys Asn Leu Arg Leu Lys Val Leu Leu Glu Thr Asn Leu Arg Phe Pro 
    50                  55                  60                  


Pro Ile Cys Val Trp Trp Pro Tyr Asp 
65                  70              


<210>  8839
<211>  2397
<212>  DNA
<213>  Homosapiens

<400>  8839
gcagagtttt gaggcagagc tgatcaaggg aacctcaaca aacaacccca gccatggagg     60

cggcggtgtc tttgaagacc ccatgagagc atcaaacaag ggagagagcc tggaacaaat    120

catggtagta aaatggcggc agagagctag taatgtgtct gcaattggtg ggttcttggt    180

cgcactgact tcaagaatga agccgcggac cctcacggtg gtgtctttgg tggctgttca    240

cccttccaca gtaaacatgc ttgggaagca actttgccaa aagccttcgg acagtccagc    300

gtcaacaccg caagccaagt ggaggagaaa aatctgcgcc tctttctctc aagggatact    360

ttgtctctgg ggtactttct gacccagtgg acccctggca gaagtaagcg tggactgtgg    420

ctgcaggacc acgcagagtc aacacgaacc gaagccaggc cttggccacg gcagctctgg    480

ggtccaacca cttgatcaat gcaggaaatg ctttgatggc agaattcttc catggccagc    540

ttctcatatt ctctgggaca gacacaaacc aagaaaaatg agtgtggcgc agaatctgat    600

gtgtccttcc ttaccccgtg ctggtagcaa aaagtatgtc ttgaactttt ctttgttaca    660

cacagtctgg gtaataacag actgaaggaa aactaaagaa gcttgggagg ctaagttcaa    720

tgacaaatga agaactaagg cagagaaaaa agagaattga gaaagtgtct gggtgtctgg    780

agaggttggg ggaatagaga gggaggagat ataattggcc agataacttg agagtgggag    840

aggagtgcaa acattatttt tgaggcgctt tgttggatat ttaaaatgca ctcctacctt    900

tggcattttc tcaaaaggca agaaagattt gttttcaatt ctatttttct gctggactga    960

accagtgcca agactggacc atgtaggatc ctgggtttat ttcagttaca taagcaaacg   1020

ttgctgtgat ttggaatagt caaagtcatg aatgtttctc aacttccatt ttgtcagctg   1080

cttgagtttc tattctgaga ggtgctaact gtgaacattg ttattcactt gtgttcccta   1140

aatcactttt aattagtttt aatttgaacc aagaatgttc tactgttgaa actatgtcaa   1200

gaatgatcaa aaatgaaatt aataaagaat tcgcgtcaaa aaaaatttgc actaatatta   1260

cagtatttta taatgtctat ctcagcagag tcacagataa tttagaattt ttaattttgt   1320

ttttaagtga ttttcctcaa agctataata gccttggtaa agagtttagt taaacattat   1380

ttttcacctc tcacgcattt tgtgtaatga aatttttcta tcatcttcca gtggaattaa   1440

ttgcattggt gcaaaaaatg caatcaaatc gatgactgaa tttagccttt gaaacctcac   1500

gtctagctgg gatagttact atattcatta catactgaaa aatgataagc agtaagcttt   1560

tctgctaaaa aactgccaaa gataagtttt tcaaggctct caaaatatcc taaagctgac   1620

aatacaagaa atgttaaaat attgttggaa tttttaacgg aatcttcctt ctcttctttt   1680

cctgtttaag acaatagtag ttagttgtcc actaatcgtt aatacacgat tttctaacaa   1740

agacttgcat atccttttgg ctaaaaagtg gccaaatatc agagagctag aagtttggga   1800

gacagccttt agtcttttcc aaagcatgta agcccttttg aatcattttg ggtaaatggc   1860

gaagattaaa cagaattcat aaagggtttc tgatacataa gtggaatgtg cctgtgagga   1920

cactacacat gacaataatc taagcatgct ctcttttagt cccaaaacgt gtagagtaat   1980

gtcacatgaa atttacagga ggccattgac ttggactgag ctcctgcacc aggcctaaca   2040

gaccaaacca aaatggagtc actcatgctg aagttcacac caccaagcca aaactgagtt   2100

gtttatccga tcttccaaga aatcaagaaa gacagggaga taacagccca atccccaaac   2160

aggccagttt ttgctggcat gataggaagg cccctctgct tcaaactttc caaagaaagt   2220

aacttggaaa caaccaatct gctttttgtt ctccgtttct gctttcctca accattttct   2280

gaccataaaa ccaacatcct ttgctcggct catgggaaca ttcattctat tttgtagaat   2340

gaggtgttgc ccgatattct agatttgcaa ataaaagcca attaagatct ttaaatt      2397


<210>  8840
<211>  99
<212>  PRT
<213>  Homosapiens

<400>  8840

Met Arg Ala Ser Asn Lys Gly Glu Ser Leu Glu Gln Ile Met Val Val 
1               5                   10                  15      


Lys Trp Arg Gln Arg Ala Ser Asn Val Ser Ala Ile Gly Gly Phe Leu 
            20                  25                  30          


Val Ala Leu Thr Ser Arg Met Lys Pro Arg Thr Leu Thr Val Val Ser 
        35                  40                  45              


Leu Val Ala Val His Pro Ser Thr Val Asn Met Leu Gly Lys Gln Leu 
    50                  55                  60                  


Cys Gln Lys Pro Ser Asp Ser Pro Ala Ser Thr Pro Gln Ala Lys Trp 
65                  70                  75                  80  


Arg Arg Lys Ile Cys Ala Ser Phe Ser Gln Gly Ile Leu Cys Leu Trp 
                85                  90                  95      


Gly Thr Phe 
            


<210>  8841
<211>  1405
<212>  DNA
<213>  Homosapiens

<400>  8841
aacaaatcat ggtagtaaaa tggcggcaga gagctagtaa tgtgtctgca attggtgggt     60

tcttggtcgc actgacttca agaatgaagc cgcggaccct cacggtatga cagctcctct    120

cccaacagct ctactttcta catctactct ctaccaccac aaaacttctt tcagttccat    180

gaaagggcca tgtttttctg gtctcttggc ctaggagcat gttgttcttc tgccagcaac    240

cttcttcaac catctccaca ggatgactcc tctattggat acttccatga aaagtccagg    300

cctgggttat gtacccttcc caaagtgcac cccagacacc caacagtttt tccagcccag    360

actcaccaca ctgtgtggta atttcctgat cactcagttg tgctccccac agactataag    420

ctctatgagg gcaggggcca cagtttgctt gttcactact atatgctcag tacctggtaa    480

atattagttg actgaagaat gactatgtgg taatctattc cattggtggc ctccagtgaa    540

ccatgtcttc tggtatttac atcttgtgtg gtcccctcca ttaaatttgg gctttaacca    600

acagaatgct gcagaagcga caccctgcca cttgtgcttt tgtgatccta gccaccagta    660

agaagccctg tgaccttgct gagaccctga agagaccaca tagagaggcc acttgaaggg    720

caaggggtcc tgactctaca tggagagaga agcccagcca tccctgtttc ccagctgagt    780

cctgaccaga taactcacta caagactgac cacaggcaag aacagcagaa gagctgccca    840

gctgagccca tccaagagtg cagaatttca agcaagtaaa atgactaatg ttagaactca    900

gaatgaaggg gcctcaggtt acctgcatca ttctggtttt ttgctcctgt tttactacga    960

agcaaacacc tcgactataa gccgccatag accagggtct gtgtctcatt cgtgtctgga   1020

caatgcatca cagacactca actgttttct gcctgagcag aattaagact tggcctccta   1080

actcctccat caccatcttc tccactctct tccttggcct tcatcaccaa caccacctca   1140

tcaaccgtga aagattcaaa gagtaaggaa aaccatttct aggaccatga aatgtgtcac   1200

tggatctcct gcagaaatct gccagagcta caatgtgact ggtttctaca tgtctgacaa   1260

atttctattt aaataagtat ttttcaaaat gcaaattgct acctattctt tggccatcaa   1320

atcactttag tgggttgcaa ccggcttttt cttcttaata gaaaaggaaa tgtgttgcat   1380

ttggtaaaca tggaaattgt tttat                                         1405


<210>  8842
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  8842

Met Thr Asn Val Arg Thr Gln Asn Glu Gly Ala Ser Gly Tyr Leu His 
1               5                   10                  15      


His Ser Gly Phe Leu Leu Leu Phe Tyr Tyr Glu Ala Asn Thr Ser Thr 
            20                  25                  30          


Ile Ser Arg His Arg Pro Gly Ser Val Ser His Ser Cys Leu Asp Asn 
        35                  40                  45              


Ala Ser Gln Thr Leu Asn Cys Phe Leu Pro Glu Gln Asn 
    50                  55                  60      


<210>  8843
<211>  2914
<212>  DNA
<213>  Homosapiens

<400>  8843
gtgctccacc actccctccc atcccgaggt gatctttgcc tgctcttctc tacccaagct     60

caagagctgc ttctgttgct atctaagaac tgcataccct cctccctgct tcttcccttg    120

tgcctcatgc tattgcttgc ttcagctgca gcctgcctgt gctggctgct ggggtcgata    180

ggcttttgtc gtaataggca gagatgactt gcatcccagc tttccaccaa ccaaattcaa    240

acattcactg cttatttgtt acagactgta attattaaag tccctgagag ctgttttctc    300

ccgttccttt ttcgcatgct tggcctcctc tctgtttcta tgaaccacag accacctaag    360

caagctgctg agtaagggct cactggaaac ttgcagtcac aggatgtcca atctttggca    420

gtccgagctt ggctctagga cagagctgtc caatagaaat ataatgtgag ccccatatac    480

aatttttaca tttctaatat attttaaaca agtgaagtta atatgcatcc aaaatatttc    540

aacctgtaat caacataaaa ttttaatgag atattttata ttattttttg gtactgaatc    600

ttcaaaatcc agagtgtatt ttacacttac cgcacatctc cattcagact agtcacattt    660

ttaagtgctc agtagccaca tgtggctggt ggctactgga ttagacagca cgagtctgga    720

agatggaagc tagtgcagaa acctcttgtt taaaaaacaa aaaaggcaag atgggcttga    780

gcgattcaag aggcaactaa aaataaaatt aggacccagc accttgtttg acacacagtt    840

tgaccttcga ttttcctccc ttaacttccc tcttccctta atatctgtat acaagtgttg    900

cttcaaagta ccaaggtcag aaattgattg agtacggttt actaaagtca tgtggaataa    960

agccattgga aacaaatgga aagcctgtcg ggacttctgg gctcagaacc agctggctca   1020

cgcactccac ttgtcagctg gacttctgcc ttgtgaaatg gaagcagcct ttgttccttt   1080

ctggctgagc aagctcctga ggctgggaga gactaggaag gcttggtagg aggggaaaaa   1140

agtcaggaaa atatatcaaa tcagaaacat ggaagaagaa gggaaccgat ttgagttggt   1200

gggcaaaact ctaaaaatct aaatctgatg cttatgtaag ggttgagcga attagggaga   1260

ttgctagtgg aaattggagg gaatttgttt tgcatcattt gtctaggatc tatgcaaata   1320

tagctccact aaaggaccat agggaagagc cagccttgcc ttttcttata tgattttgtt   1380

tacaaaattt tactgggact tttaaatcta gctatagagt tgggaaaaaa tatttccact   1440

tagatatttt acatggtttt gtttaaaatt accattactt gttttttaaa aacacatgac   1500

cacatatgta tatgtatatc tacctaaaca ttgtatcatg gtttcagtat gttattcatg   1560

tattactggg agatgctacc aagaaaccaa cccaaagaaa attctgaaaa atacatttct   1620

atttatagaa taaatgtttc atttatataa aagcaaaaga acttagagtt ctaataaatg   1680

ggatgtctaa taaattatga agttactgat ttgaatatat tatatttcta taacttcctt   1740

gccaaagtcc tgatttagta cattagagaa cctgtgtttc ctctctcctc taccattcat   1800

ctctcttcca tacagtcatt tgggcttttt actcaaagag aatcaagaaa taataaggta   1860

taacaagctt ggcaaagtgt tggcttttta aaaaaaaatt tttttaatct ctagcagttt   1920

ggtaatttag cagcatcatt tatttgggat tcttttatct gatttcaaca gtgaaaaaca   1980

tccctatgat aaagcctaat gacccatttc acaaaagatg gaatttgccc ttcctagaaa   2040

atatgacgga gaaaagtctg actcagagaa agtgggtctg aattttataa ggggtagtaa   2100

gaattggaca attcctttgc atatctgaac ttggcaggta ccgttctaaa tctgaaacag   2160

ggtgatagct caaagttgcc attcatccag aatagattgt tttagaatgt agtgtttaag   2220

tgactgtttc attaatacac ctacaccctt tctttgaaag tttgcaacct aattgcatct   2280

aaaactatga ataagttctg tggtaaaatc ttaaactatg gaaaattaca aaaatgaatt   2340

tttcttccct gaaatcagag cttacatgtg tgttttttta taacattttc agataaatgt   2400

attcaacatg taatacagta ttttaacatt cacctcttat tttatattga aatgtattac   2460

agtattaaaa ctcagtgttc agtatttatt tcactatgca ttttatttag taaaagccag   2520

gagaaatgtt taatccaatg gtgccttact ttgtgattta aaagaaatca actttttttt   2580

atgtctaagt agtagattat ttgcatattt gtaaaaactg ttaggtcttt atattttaaa   2640

gtgtaatacc agttttgtta ttttagtagc agaaatggga tgattgttaa agttccccaa   2700

aaatgttggc atgaaattaa tttttccctc cttatagtca aggaccgtag aggaagaaaa   2760

actttttttt cataccatgc actatgtaaa cagacacatt ttgctatctg tgtcatcagg   2820

atagtgtaag tggtagggta gagactaccc tagacatctg catctttgta agttagccag   2880

acaataaaga aaagcagaat gatatggtgt caac                               2914


<210>  8844
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  8844

Met Trp Asn Lys Ala Ile Gly Asn Lys Trp Lys Ala Cys Arg Asp Phe 
1               5                   10                  15      


Trp Ala Gln Asn Gln Leu Ala His Ala Leu His Leu Ser Ala Gly Leu 
            20                  25                  30          


Leu Pro Cys Glu Met Glu Ala Ala Phe Val Pro Phe Trp Leu Ser Lys 
        35                  40                  45              


Leu Leu Arg Leu Gly Glu Thr Arg Lys Ala Trp 
    50                  55                  


<210>  8845
<211>  4594
<212>  DNA
<213>  Homosapiens

<400>  8845
tagaagacag caggggaact cgagaagttg gttgttttca gcagattaaa acaatacaga     60

tttatcagca agactgttga acgcataact gcccaagatg cctgtccctc cccctccagc    120

acccccgccg cccccgacgt ttgcactggc caatacagag aagcctacct tgaataagac    180

agagcaggct gggagaaatg ctctcctttc tgatatcagc aaagggaaga aactaaagaa    240

gacggtcacc aatgacagaa gtgcaccaat actggacaaa cctaaaggag ctggtgctgg    300

aggcggtggt ggtggctttg gtggaggcgg cggatttggc ggaggaggtg gtggcggagg    360

cggtggaagt tttggagggg gcggacctcc aggtctggga ggattgttcc aggctggaat    420

gccgaagctg agatccacgg ccaacaggga taatgattct ggaggaagcc gaccaccatt    480

gttgccaccg ggaggaagat ccacatctgc gaaacccttt tcacccccaa gtggcccagg    540

gaggtttcct gtgccttctc caggccacag aagtggtccc ccagagcctc agaggaaccg    600

aatgccgccc ccaaggcccg acgtgggctc aaagcctgat agcattcctc ctccagtacc    660

tagtactcca agacccattc aatcaagtcc gcacaaccgg gggtccccac cagtgcccgg    720

aggccccagg cagcccagcc ccgggcccac tcctccccct ttccctggaa accgcggcac    780

tgctttggga ggaggctcaa tacgtcagtc ccccttgagc tcctcctcgc ccttctccaa    840

ccggcctccc ctgccgccta cccccagcag ggccttggat gacaaacccc ctccaccacc    900

tcctccagtg ggcaacaggc cctccatcca cagggaagcg gttccccctc ctcctcctca    960

gaacaacaag cctccagtgc cttccactcc gcggccttcg gcctcctcac aggccccacc   1020

tccgccgcca cctcccagca ggcccgggcc gcctcctctg cctccaagtt ccagcggcaa   1080

tgacgaaacc ccaagactcc cacagcggaa tctgtccctc agttcgtcca cgcccccgtt   1140

accttcgcca ggacgttcag gtcctcttcc tcccccgccc agtgagagac ccccacctcc   1200

agtgagggac ccgccaggcc gatcaggccc cctcccacca cctcctccag taagcagaaa   1260

cggcagcaca tctcgggccc tgcctgctac ccctcagttg ccatccagga gtggagtaga   1320

cagtcccagg agtggaccca ggcctcccct tcctcctgat aggcccagtg ctggggcacc   1380

tcccccacct ccaccatcaa catctattag aaatggcttc caagactctc catgtgaaga   1440

tgagtgggaa agcagattct acttccatcc gatttccgat ttgccacctc cagagccata   1500

tgtacaaacg accaaaagtt atcccagcaa actggcaaga aacgaaagcc ggagtggatc   1560

caaccgaaga gaaaggggtg ctccaccact ccctcccatc ccgaggtgat ctttgcctgc   1620

tcttctctac ccaagctcaa gagctgcttc tgttgctatc taagaactgc ataccctcct   1680

ccctgcttct tcccttgtgc ctcatgtatg ggcaggagga aaggtgggag ggggagtggg   1740

aatatgcgtg tgtgggtggg aatcggtaag aaatgcacct agcttttcat attgtgttta   1800

ttctccaggc tattgcttgc ttcagctgca gcctgcctgt gctggctgct ggggtcgata   1860

ggcttttgtc gtaataggca gagatgactt gcatcccagc tttccaccaa ccaaattcaa   1920

acattcactg cttatttgtt acagactgta attattaaag tccctgagag ctgttttctc   1980

ccgttccttt ttcgcatgct tggcctcctc tctgtttcta tgaaccacag accacctaag   2040

caagctgctg agtaagggct cactggaaac ttgcagtcac aggatgtcca atctttggca   2100

gtccgagctt ggctctagga cagagctgtc caatagaaat ataatgtgag ccccatatac   2160

aatttttaca tttctaatat attttaaaca agtgaagtta atatgcatcc aaaatatttc   2220

aacctgtaat caacataaaa ttttaatgag atattttata ttattttttg gtactgaatc   2280

ttcaaaatcc agagtgtatt ttacacttac cgcacatctc cattcagact agtcacattt   2340

ttaagtgctc agtagccaca tgtggctggt ggctactgga ttagacagca cgagtctgga   2400

agatggaagc tagtgcagaa acctcttgtt taaaaaacaa aaaaggcaag atgggcttga   2460

gcgattcaag aggcaactaa aaataaaatt aggacccagc accttgtttg acacacagtt   2520

tgaccttcga ttttcctccc ttaacttccc tcttccctta atatctgtat acaagtgttg   2580

cttcaaagta ccaaggtcag aaattgattg agtacggttt actaaagtca tgtggaataa   2640

agccattgga aacaaatgga aagcctgtcg ggacttctgg gctcagaacc agctggctca   2700

cgcactccac ttgtcagctg gacttctgcc ttgtgaaatg gaagcagcct ttgttccttt   2760

ctggctgagc aagctcctga ggctgggaga gactaggaag gcttggtagg aggggaaaaa   2820

agtcaggaaa atatatcaaa tcagaaacat ggaagaagaa gggaaccgat ttgagttggt   2880

gggcaaaact ctaaaaatct aaatctgatg cttatgtaag ggttgagcga attagggaga   2940

ttgctagtgg aaattggagg gaatttgttt tgcatcattt gtctaggatc tatgcaaata   3000

tagctccact aaaggaccat agggaagagc cagccttgcc ttttcttata tgattttgtt   3060

tacaaaattt tactgggact tttaaatcta gctatagagt tgggaaaaaa tatttccact   3120

tagatatttt acatggtttt gtttaaaatt accattactt gttttttaaa aacacatgac   3180

cacatatgta tatgtatatc tacctaaaca ttgtatcatg gtttcagtat gttattcatg   3240

tattactggg agatgctacc aagaaaccaa cccaaagaaa attctgaaaa atacatttct   3300

atttatagaa taaatgtttc atttatataa aagcaaaaga acttagagtt ctaataaatg   3360

ggatgtctaa taaattatga agttactgat ttgaatatat tatatttcta taacttcctt   3420

gccaaagtcc tgatttagta cattagagaa cctgtgtttc ctctctcctc taccattcat   3480

ctctcttcca tacagtcatt tgggcttttt actcaaagag aatcaagaaa taataaggta   3540

taacaagctt ggcaaagtgt tggcttttta aaaaaaaatt tttttaatct ctagcagttt   3600

ggtaatttag cagcatcatt tatttgggat tcttttatct gatttcaaca gtgaaaaaca   3660

tccctatgat aaagcctaat gacccatttc acaaaagatg gaatttgccc ttcctagaaa   3720

atatgacgga gaaaagtctg actcagagaa agtgggtctg aattttataa ggggtagtaa   3780

gaattggaca attcctttgc atatctgaac ttggcaggta ccgttctaaa tctgaaacag   3840

ggtgatagct caaagttgcc attcatccag aatagattgt tttagaatgt agtgtttaag   3900

tgactgtttc attaatacac ctacaccctt tctttgaaag tttgcaacct aattgcatct   3960

aaaactatga ataagttctg tggtaaaatc ttaaactatg gaaaattaca aaaatgaatt   4020

tttcttccct gaaatcagag cttacatgtg tgttttttta taacattttc agataaatgt   4080

attcaacatg taatacagta ttttaacatt cacctcttat tttatattga aatgtattac   4140

agtattaaaa ctcagtgttc agtatttatt tcactatgca ttttatttag taaaagccag   4200

gagaaatgtt taatccaatg gtgccttact ttgtgattta aaagaaatca actttttttt   4260

atgtctaagt agtagattat ttgcatattt gtaaaaactg ttaggtcttt atattttaaa   4320

gtgtaatacc agttttgtta ttttagtagc agaaatggga tgattgttaa agttccccaa   4380

aaatgttggc atgaaattaa tttttccctc cttatagtca aggaccgtag aggaagaaaa   4440

actttttttt cataccatgc actatgtaaa cagacacatt ttgctatctg tgtcatcagg   4500

atagtgtaag tggtagggta gagactaccc tagacatctg catctttgta agttagccag   4560

acaataaaga aaagcagaat gatatggtgt caac                               4594


<210>  8846
<211>  503
<212>  PRT
<213>  Homosapiens

<400>  8846

Met Pro Val Pro Pro Pro Pro Ala Pro Pro Pro Pro Pro Thr Phe Ala 
1               5                   10                  15      


Leu Ala Asn Thr Glu Lys Pro Thr Leu Asn Lys Thr Glu Gln Ala Gly 
            20                  25                  30          


Arg Asn Ala Leu Leu Ser Asp Ile Ser Lys Gly Lys Lys Leu Lys Lys 
        35                  40                  45              


Thr Val Thr Asn Asp Arg Ser Ala Pro Ile Leu Asp Lys Pro Lys Gly 
    50                  55                  60                  


Ala Gly Ala Gly Gly Gly Gly Gly Gly Phe Gly Gly Gly Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Phe Gly Gly Gly Gly 
                85                  90                  95      


Pro Pro Gly Leu Gly Gly Leu Phe Gln Ala Gly Met Pro Lys Leu Arg 
            100                 105                 110         


Ser Thr Ala Asn Arg Asp Asn Asp Ser Gly Gly Ser Arg Pro Pro Leu 
        115                 120                 125             


Leu Pro Pro Gly Gly Arg Ser Thr Ser Ala Lys Pro Phe Ser Pro Pro 
    130                 135                 140                 


Ser Gly Pro Gly Arg Phe Pro Val Pro Ser Pro Gly His Arg Ser Gly 
145                 150                 155                 160 


Pro Pro Glu Pro Gln Arg Asn Arg Met Pro Pro Pro Arg Pro Asp Val 
                165                 170                 175     


Gly Ser Lys Pro Asp Ser Ile Pro Pro Pro Val Pro Ser Thr Pro Arg 
            180                 185                 190         


Pro Ile Gln Ser Ser Pro His Asn Arg Gly Ser Pro Pro Val Pro Gly 
        195                 200                 205             


Gly Pro Arg Gln Pro Ser Pro Gly Pro Thr Pro Pro Pro Phe Pro Gly 
    210                 215                 220                 


Asn Arg Gly Thr Ala Leu Gly Gly Gly Ser Ile Arg Gln Ser Pro Leu 
225                 230                 235                 240 


Ser Ser Ser Ser Pro Phe Ser Asn Arg Pro Pro Leu Pro Pro Thr Pro 
                245                 250                 255     


Ser Arg Ala Leu Asp Asp Lys Pro Pro Pro Pro Pro Pro Pro Val Gly 
            260                 265                 270         


Asn Arg Pro Ser Ile His Arg Glu Ala Val Pro Pro Pro Pro Pro Gln 
        275                 280                 285             


Asn Asn Lys Pro Pro Val Pro Ser Thr Pro Arg Pro Ser Ala Ser Ser 
    290                 295                 300                 


Gln Ala Pro Pro Pro Pro Pro Pro Pro Ser Arg Pro Gly Pro Pro Pro 
305                 310                 315                 320 


Leu Pro Pro Ser Ser Ser Gly Asn Asp Glu Thr Pro Arg Leu Pro Gln 
                325                 330                 335     


Arg Asn Leu Ser Leu Ser Ser Ser Thr Pro Pro Leu Pro Ser Pro Gly 
            340                 345                 350         


Arg Ser Gly Pro Leu Pro Pro Pro Pro Ser Glu Arg Pro Pro Pro Pro 
        355                 360                 365             


Val Arg Asp Pro Pro Gly Arg Ser Gly Pro Leu Pro Pro Pro Pro Pro 
    370                 375                 380                 


Val Ser Arg Asn Gly Ser Thr Ser Arg Ala Leu Pro Ala Thr Pro Gln 
385                 390                 395                 400 


Leu Pro Ser Arg Ser Gly Val Asp Ser Pro Arg Ser Gly Pro Arg Pro 
                405                 410                 415     


Pro Leu Pro Pro Asp Arg Pro Ser Ala Gly Ala Pro Pro Pro Pro Pro 
            420                 425                 430         


Pro Ser Thr Ser Ile Arg Asn Gly Phe Gln Asp Ser Pro Cys Glu Asp 
        435                 440                 445             


Glu Trp Glu Ser Arg Phe Tyr Phe His Pro Ile Ser Asp Leu Pro Pro 
    450                 455                 460                 


Pro Glu Pro Tyr Val Gln Thr Thr Lys Ser Tyr Pro Ser Lys Leu Ala 
465                 470                 475                 480 


Arg Asn Glu Ser Arg Ser Gly Ser Asn Arg Arg Glu Arg Gly Ala Pro 
                485                 490                 495     


Pro Leu Pro Pro Ile Pro Arg 
            500             


<210>  8847
<211>  4236
<212>  DNA
<213>  Homosapiens

<400>  8847
gcagcctccc ggcgctgagc gcttttcctg cccgcccggc tcagccctgc ggaccccggg     60

agaagtttcc cagaaaaaat gcccagcgcg gcgcggggct gcggagtcgt ccggagccgc    120

tgcgcgattt atcagcaaga ctgttgaacg cataactgcc caagatgcct gtccctcccc    180

ctccagcacc cccgccgccc ccgacgtttg cactggccaa tacagagaag cctaccttga    240

ataagacaga gcaggctggg agaaatgctc tcctttctga tatcagcaaa gggaagaaac    300

taaagaagac ggtcaccaat gacagaagtg caccaatact ggacaaacct aaaggagctg    360

gtgctggagg cggtggtggt ggctttggtg gaggcggcgg atttggcgga ggaggtggtg    420

gcggaggcgg tggaagtttt ggagggggcg gacctccagg tctgggagga ttgttccagg    480

ctggaatgcc gaagctgaga tccacggcca acagggataa tgattctgga ggaagccgac    540

caccattgtt gccaccggga ggaagatcca catctgcgaa acccttttca cccccaagtg    600

gcccagggag gtttcctgtg ccttctccag gccacagaag tggtccccca gagcctcaga    660

ggaaccgaat gccgccccca aggcccgacg tgggctcaaa gcctgatagc attcctcctc    720

cagtacctag tactccaaga cccattcaat caagtccgca caaccggggg tccccaccag    780

tgcccggagg ccccaggcag cccagccccg ggcccactcc tccccctttc cctggaaacc    840

gcggcactgc tttgggagga ggctcaatac gtcagtcccc cttgagctcc tcctcgccct    900

tctccaaccg gcctcccctg ccgcctaccc ccagcagggc cttggatgac aaaccccctc    960

caccacctcc tccagtgggc aacaggccct ccatccacag ggaagcggtt ccccctcctc   1020

ctcctcagaa caacaagcct ccagtgcctt ccactccgcg gccttcggcc tcctcacagg   1080

ccccacctcc gccgccacct cccagcaggc ccgggccgcc tcctctgcct ccaagttcca   1140

gcggcaatga cgaaacccca agactcccac agcggaatct gtccctcagt tcgtccacgc   1200

ccccgttacc ttcgccagga cgttcaggtc ctcttcctcc cccgcccagt gagagacccc   1260

cacctccagt gagggacccg ccaggccgat caggccccct cccaccacct cctccagtaa   1320

gcagaaacgg cagcacatct cgggccctgc ctgctacccc tcagttgcca tccaggagtg   1380

gagtagacag tcccaggagt ggacccaggc ctccccttcc tcctgatagg cccagtgctg   1440

gggcacctcc cccacctcca ccatcaacat ctattagaaa tggcttccaa gactctccat   1500

gtgaagatga gtgggaaagc agattctact tccatccgat ttccgatttg ccacctccag   1560

agccatatgt acaaacgacc aaaagttatc ccagcaaact ggcaagaaac gaaagccgga   1620

gtggatccaa ccgaagagaa aggggtgctc caccactccc tcccatcccg agaccaccta   1680

agcaagctgc tgagtaaggg ctcactggaa acttgcagtc acaggatgtc caatctttgg   1740

cagtccgagc ttggctctag gacagagctg tccaatagaa atataatgtg agccccatat   1800

acaattttta catttctaat atattttaaa caagtgaagt taatatgcat ccaaaatatt   1860

tcaacctgta atcaacataa aattttaatg agatatttta tattattttt tggtactgaa   1920

tcttcaaaat ccagagtgta ttttacactt accgcacatc tccattcaga ctagtcacat   1980

ttttaagtgc tcagtagcca catgtggctg gtggctactg gattagacag cacgagtctg   2040

gaagatggaa gctagtgcag aaacctcttg tttaaaaaac aaaaaaggca agatgggctt   2100

gagcgattca agaggcaact aaaaataaaa ttaggaccca gcaccttgtt tgacacacag   2160

tttgaccttc gattttcctc ccttaacttc cctcttccct taatatctgt atacaagtgt   2220

tgcttcaaag taccaaggtc agaaattgat tgagtacggt ttactaaagt catgtggaat   2280

aaagccattg gaaacaaatg gaaagcctgt cgggacttct gggctcagaa ccagctggct   2340

cacgcactcc acttgtcagc tggacttctg ccttgtgaaa tggaagcagc ctttgttcct   2400

ttctggctga gcaagctcct gaggctggga gagactagga aggcttggta ggaggggaaa   2460

aaagtcagga aaatatatca aatcagaaac atggaagaag aagggaaccg atttgagttg   2520

gtgggcaaaa ctctaaaaat ctaaatctga tgcttatgta agggttgagc gaattaggga   2580

gattgctagt ggaaattgga gggaatttgt tttgcatcat ttgtctagga tctatgcaaa   2640

tatagctcca ctaaaggacc atagggaaga gccagccttg ccttttctta tatgattttg   2700

tttacaaaat tttactggga cttttaaatc tagctataga gttgggaaaa aatatttcca   2760

cttagatatt ttacatggtt ttgtttaaaa ttaccattac ttgtttttta aaaacacatg   2820

accacatatg tatatgtata tctacctaaa cattgtatca tggtttcagt atgttattca   2880

tgtattactg ggagatgcta ccaagaaacc aacccaaaga aaattctgaa aaatacattt   2940

ctatttatag aataaatgtt tcatttatat aaaagcaaaa gaacttagag ttctaataaa   3000

tgggatgtct aataaattat gaagttactg atttgaatat attatatttc tataacttcc   3060

ttgccaaagt cctgatttag tacattagag aacctgtgtt tcctctctcc tctaccattc   3120

atctctcttc catacagtca tttgggcttt ttactcaaag agaatcaaga aataataagg   3180

tataacaagc ttggcaaagt gttggctttt taaaaaaaaa tttttttaat ctctagcagt   3240

ttggtaattt agcagcatca tttatttggg attcttttat ctgatttcaa cagtgaaaaa   3300

catccctatg ataaagccta atgacccatt tcacaaaaga tggaatttgc ccttcctaga   3360

aaatatgacg gagaaaagtc tgactcagag aaagtgggtc tgaattttat aaggggtagt   3420

aagaattgga caattccttt gcatatctga acttggcagg taccgttcta aatctgaaac   3480

agggtgatag ctcaaagttg ccattcatcc agaatagatt gttttagaat gtagtgttta   3540

agtgactgtt tcattaatac acctacaccc tttctttgaa agtttgcaac ctaattgcat   3600

ctaaaactat gaataagttc tgtggtaaaa tcttaaacta tggaaaatta caaaaatgaa   3660

tttttcttcc ctgaaatcag agcttacatg tgtgtttttt tataacattt tcagataaat   3720

gtattcaaca tgtaatacag tattttaaca ttcacctctt attttatatt gaaatgtatt   3780

acagtattaa aactcagtgt tcagtattta tttcactatg cattttattt agtaaaagcc   3840

aggagaaatg tttaatccaa tggtgcctta ctttgtgatt taaaagaaat caactttttt   3900

ttatgtctaa gtagtagatt atttgcatat ttgtaaaaac tgttaggtct ttatatttta   3960

aagtgtaata ccagttttgt tattttagta gcagaaatgg gatgattgtt aaagttcccc   4020

aaaaatgttg gcatgaaatt aatttttccc tccttatagt caaggaccgt agaggaagaa   4080

aaactttttt ttcataccat gcactatgta aacagacaca ttttgctatc tgtgtcatca   4140

ggatagtgta agtggtaggg tagagactac cctagacatc tgcatctttg taagttagcc   4200

agacaataaa gaaaagcaga atgatatggt gtcaac                             4236


<210>  8848
<211>  510
<212>  PRT
<213>  Homosapiens

<400>  8848

Met Pro Val Pro Pro Pro Pro Ala Pro Pro Pro Pro Pro Thr Phe Ala 
1               5                   10                  15      


Leu Ala Asn Thr Glu Lys Pro Thr Leu Asn Lys Thr Glu Gln Ala Gly 
            20                  25                  30          


Arg Asn Ala Leu Leu Ser Asp Ile Ser Lys Gly Lys Lys Leu Lys Lys 
        35                  40                  45              


Thr Val Thr Asn Asp Arg Ser Ala Pro Ile Leu Asp Lys Pro Lys Gly 
    50                  55                  60                  


Ala Gly Ala Gly Gly Gly Gly Gly Gly Phe Gly Gly Gly Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Phe Gly Gly Gly Gly 
                85                  90                  95      


Pro Pro Gly Leu Gly Gly Leu Phe Gln Ala Gly Met Pro Lys Leu Arg 
            100                 105                 110         


Ser Thr Ala Asn Arg Asp Asn Asp Ser Gly Gly Ser Arg Pro Pro Leu 
        115                 120                 125             


Leu Pro Pro Gly Gly Arg Ser Thr Ser Ala Lys Pro Phe Ser Pro Pro 
    130                 135                 140                 


Ser Gly Pro Gly Arg Phe Pro Val Pro Ser Pro Gly His Arg Ser Gly 
145                 150                 155                 160 


Pro Pro Glu Pro Gln Arg Asn Arg Met Pro Pro Pro Arg Pro Asp Val 
                165                 170                 175     


Gly Ser Lys Pro Asp Ser Ile Pro Pro Pro Val Pro Ser Thr Pro Arg 
            180                 185                 190         


Pro Ile Gln Ser Ser Pro His Asn Arg Gly Ser Pro Pro Val Pro Gly 
        195                 200                 205             


Gly Pro Arg Gln Pro Ser Pro Gly Pro Thr Pro Pro Pro Phe Pro Gly 
    210                 215                 220                 


Asn Arg Gly Thr Ala Leu Gly Gly Gly Ser Ile Arg Gln Ser Pro Leu 
225                 230                 235                 240 


Ser Ser Ser Ser Pro Phe Ser Asn Arg Pro Pro Leu Pro Pro Thr Pro 
                245                 250                 255     


Ser Arg Ala Leu Asp Asp Lys Pro Pro Pro Pro Pro Pro Pro Val Gly 
            260                 265                 270         


Asn Arg Pro Ser Ile His Arg Glu Ala Val Pro Pro Pro Pro Pro Gln 
        275                 280                 285             


Asn Asn Lys Pro Pro Val Pro Ser Thr Pro Arg Pro Ser Ala Ser Ser 
    290                 295                 300                 


Gln Ala Pro Pro Pro Pro Pro Pro Pro Ser Arg Pro Gly Pro Pro Pro 
305                 310                 315                 320 


Leu Pro Pro Ser Ser Ser Gly Asn Asp Glu Thr Pro Arg Leu Pro Gln 
                325                 330                 335     


Arg Asn Leu Ser Leu Ser Ser Ser Thr Pro Pro Leu Pro Ser Pro Gly 
            340                 345                 350         


Arg Ser Gly Pro Leu Pro Pro Pro Pro Ser Glu Arg Pro Pro Pro Pro 
        355                 360                 365             


Val Arg Asp Pro Pro Gly Arg Ser Gly Pro Leu Pro Pro Pro Pro Pro 
    370                 375                 380                 


Val Ser Arg Asn Gly Ser Thr Ser Arg Ala Leu Pro Ala Thr Pro Gln 
385                 390                 395                 400 


Leu Pro Ser Arg Ser Gly Val Asp Ser Pro Arg Ser Gly Pro Arg Pro 
                405                 410                 415     


Pro Leu Pro Pro Asp Arg Pro Ser Ala Gly Ala Pro Pro Pro Pro Pro 
            420                 425                 430         


Pro Ser Thr Ser Ile Arg Asn Gly Phe Gln Asp Ser Pro Cys Glu Asp 
        435                 440                 445             


Glu Trp Glu Ser Arg Phe Tyr Phe His Pro Ile Ser Asp Leu Pro Pro 
    450                 455                 460                 


Pro Glu Pro Tyr Val Gln Thr Thr Lys Ser Tyr Pro Ser Lys Leu Ala 
465                 470                 475                 480 


Arg Asn Glu Ser Arg Ser Gly Ser Asn Arg Arg Glu Arg Gly Ala Pro 
                485                 490                 495     


Pro Leu Pro Pro Ile Pro Arg Pro Pro Lys Gln Ala Ala Glu 
            500                 505                 510 


<210>  8849
<211>  1692
<212>  DNA
<213>  Homosapiens

<400>  8849
agaaggacgt ctgcctctga ctcagtatgt cacatttaac aagaggccag agcttgtcca     60

aaatggctgt ccaaaaacga ccccacactt gcgttagaag atgatacctt tttcagggac    120

agttttctct cttggctcct gtcccgctgg ccctctgtct gcctgtgtcc ctgaccatgg    180

ctccctgcag taccctttaa cgatttatca gcaagactgt tgaacgcata actgcccaag    240

atgcctgtcc ctccccctcc agcacccccg ccgcccccga cgtttgcact ggccaataca    300

gagaagccta ccttgaataa gacagagcag gctgggagaa atgctctcct ttctgatatc    360

agcaaaggga agaaactaaa gaagacggtc accaatgaca gaagtgcacc aatactggac    420

aaacctaaag gagctggtgc tggaggcggt ggtggtggct ttggtggagg cggcggattt    480

ggcggaggag gtggtggcgg aggcggtgga agttttggag ggggcggacc tccaggtctg    540

ggaggattgt tccaggctgg aatgccgaag ctgagatcca cggccaacag ggataatgat    600

tctggaggaa gccgaccacc attgttgcca ccgggaggaa gatccacatc tgcgaaaccc    660

ttttcacccc caagtggccc agggaggttt cctgtgcctt ctccaggcca cagaagtggt    720

cccccagagc ctcagaggaa ccgaatgccg cccccaaggc ccgacgtggg ctcaaagcct    780

gatagcattc ctcctccagt acctagtact ccaagaccca ttcaatcaag tccgcacaac    840

cgggggtccc caccagtgcc cggaggcccc aggcagccca gccccgggcc cactcacccc    900

cacctccagt gagggacccg ccaggccgat caggccccct cccaccacct cctccagtaa    960

gcagaaacgg cagcacatct cgggccctgc ctgctacccc tcagttgcca tccaggagtg   1020

gagtagacag tcccaggagt ggacccaggc ctccccttcc tcctgatagg cccagtgctg   1080

gggcacctcc cccacctcca ccatcaacat ctattagaaa tggcttccaa gactctccat   1140

gtgaagatga gtgggaaagc agattctact tccatccgat ttccgatttg ccacctccag   1200

agccatatgt acaaacgacc aaaagttatc ccagcaaact ggcaagaaac gaaagccgga   1260

gtggatccaa ccgaagagaa aggggtgctc caccactccc tcccatcccg aggtgatctt   1320

tgcctgctct tctctaccca agctcaagag ctgcttctgt tgctatctaa gaactgcata   1380

ccctcctccc tgcttcttcc cttgtgcctc atgtatgggc aggaggaaag gtgggagggg   1440

gagtgggaat atgcgtgtgt gggtgggaat cggtaagaaa tgcacctagc ttttcatatt   1500

gtgtttattc tccaggctat tgcttgcttc agctgcagcc tgcctgtgct ggctgctggg   1560

gtcgataggc ttttgtcgta ataggcagag atgacttgca tcccagcttt ccaccaacca   1620

aattcaaaca ttcactgctt atttgttaca gactgtaatt attaaagtcc ctgagagctg   1680

ttttctcccg tt                                                       1692


<210>  8850
<211>  223
<212>  PRT
<213>  Homosapiens

<400>  8850

Met Pro Val Pro Pro Pro Pro Ala Pro Pro Pro Pro Pro Thr Phe Ala 
1               5                   10                  15      


Leu Ala Asn Thr Glu Lys Pro Thr Leu Asn Lys Thr Glu Gln Ala Gly 
            20                  25                  30          


Arg Asn Ala Leu Leu Ser Asp Ile Ser Lys Gly Lys Lys Leu Lys Lys 
        35                  40                  45              


Thr Val Thr Asn Asp Arg Ser Ala Pro Ile Leu Asp Lys Pro Lys Gly 
    50                  55                  60                  


Ala Gly Ala Gly Gly Gly Gly Gly Gly Phe Gly Gly Gly Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Phe Gly Gly Gly Gly 
                85                  90                  95      


Pro Pro Gly Leu Gly Gly Leu Phe Gln Ala Gly Met Pro Lys Leu Arg 
            100                 105                 110         


Ser Thr Ala Asn Arg Asp Asn Asp Ser Gly Gly Ser Arg Pro Pro Leu 
        115                 120                 125             


Leu Pro Pro Gly Gly Arg Ser Thr Ser Ala Lys Pro Phe Ser Pro Pro 
    130                 135                 140                 


Ser Gly Pro Gly Arg Phe Pro Val Pro Ser Pro Gly His Arg Ser Gly 
145                 150                 155                 160 


Pro Pro Glu Pro Gln Arg Asn Arg Met Pro Pro Pro Arg Pro Asp Val 
                165                 170                 175     


Gly Ser Lys Pro Asp Ser Ile Pro Pro Pro Val Pro Ser Thr Pro Arg 
            180                 185                 190         


Pro Ile Gln Ser Ser Pro His Asn Arg Gly Ser Pro Pro Val Pro Gly 
        195                 200                 205             


Gly Pro Arg Gln Pro Ser Pro Gly Pro Thr His Pro His Leu Gln 
    210                 215                 220             


<210>  8851
<211>  1985
<212>  DNA
<213>  Homosapiens

<400>  8851
tagaagacag caggggaact cgagaagttg gttgttttca gcagattaaa acaatacaga     60

tttatcagca agactgttga acgcataact gcccaagatg cctgtccctc cccctccagc    120

acccccgccg cccccgacgt ttgcactggc caatacagag aagcctacct tgaataagac    180

agagcaggct gggagaaatg ctctcctttc tgatatcagc aaagggaaga aactaaagaa    240

gacggtcacc aatgacagaa gtgcaccaat actggacaaa cctaaaggag ctggtgctgg    300

aggcggtggt ggtggctttg gtggaggcgg cggatttggc ggaggaggtg gtggcggagg    360

cggtggaagt tttggagggg gcggacctcc aggtctggga ggattgttcc aggctggaat    420

gccgaagctg agatccacgg ccaacaggga taatgattct ggaggaagcc gaccaccatt    480

gttgccaccg ggaggaagat ccacatctgc gaaacccttt tcacccccaa gtggcccagg    540

gaggtttcct gtgccttctc caggccacag aagtggtccc ccagagcctc agaggaaccg    600

aatgccgccc ccaaggcccg acgtgggctc aaagcctgat agcattcctc ctccagtacc    660

tagtactcca agacccattc aatcaagtcc gcacaaccgg gggtccccac cagtgcccgg    720

aggccccagg cagcccagcc ccgggcccac tcctccccct ttccctggaa accgcggcac    780

tgctttggga ggaggctcaa tacgtcagtc ccccttgagc tcctcctcgc ccttctccaa    840

ccggcctccc ctgccgccta cccccagcag ggccttggat gacaaacccc ctccaccacc    900

tcctccagtg ggcaacaggc cctccatcca cagggaagcg gttccccctc ctcctcctca    960

gaacaacaag cctccagtgc cttccactcc gcggccttcg gcctcctcac aggccccacc   1020

tccgccgcca cctcccagca ggcccgggcc gcctcctctg cctccaagtt ccagcggcaa   1080

tgacgaaacc ccaagactcc cacagcggaa tctgtccctc agttcgtcca cgcccccgtt   1140

accttcgcca ggacgttcag gtcctcttcc tcccccgccc agtgagagac ccccacctcc   1200

agtgagggac ccgccaggcc gatcaggccc cctcccacca cctcctccag taagcagaaa   1260

cggcagcaca tctcgggccc tgcctgctac ccctcagttg ccatccagga gtggagtaga   1320

cagtcccagg agtggaccca ggcctcccct tcctcctgat aggcccagtg ctggggcacc   1380

tcccccacct ccaccatcaa catctattag aaatggcttc caagactctc catgtgaaga   1440

tgagtgggaa agcagattct acttccatcc gatttccgat ttgccacctc cagagccata   1500

tgtacaaacg accaaaagtt atcccagcaa actggcaaga aacgaaagcc ggagtggatc   1560

caaccgaaga gaaaggggtg ctccaccact ccctcccatc ccgaggtgat ctttgcctgc   1620

tcttctctac ccaagctcaa gagctgcttc tgttgctatc taagaactgc ataccctcct   1680

ccctgcttct tcccttgtgc ctcatgtatg ggcaggagga aaggtgggag ggggagtggg   1740

aatatgcgtg tgtgggtggg aatcggtaag aaatgcacct agcttttcat attgtgttta   1800

ttctccaggc tattgcttgc ttcagctgca gcctgcctgt gctggctgct ggggtcgata   1860

ggcttttgtc gtaataggca gagatgactt gcatcccagc tttccaccaa ccaaattcaa   1920

acattcactg cttatttgtt acagactgta attattaaag tccctgagag ctgttttctc   1980

ccgtt                                                               1985


<210>  8852
<211>  503
<212>  PRT
<213>  Homosapiens

<400>  8852

Met Pro Val Pro Pro Pro Pro Ala Pro Pro Pro Pro Pro Thr Phe Ala 
1               5                   10                  15      


Leu Ala Asn Thr Glu Lys Pro Thr Leu Asn Lys Thr Glu Gln Ala Gly 
            20                  25                  30          


Arg Asn Ala Leu Leu Ser Asp Ile Ser Lys Gly Lys Lys Leu Lys Lys 
        35                  40                  45              


Thr Val Thr Asn Asp Arg Ser Ala Pro Ile Leu Asp Lys Pro Lys Gly 
    50                  55                  60                  


Ala Gly Ala Gly Gly Gly Gly Gly Gly Phe Gly Gly Gly Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Phe Gly Gly Gly Gly 
                85                  90                  95      


Pro Pro Gly Leu Gly Gly Leu Phe Gln Ala Gly Met Pro Lys Leu Arg 
            100                 105                 110         


Ser Thr Ala Asn Arg Asp Asn Asp Ser Gly Gly Ser Arg Pro Pro Leu 
        115                 120                 125             


Leu Pro Pro Gly Gly Arg Ser Thr Ser Ala Lys Pro Phe Ser Pro Pro 
    130                 135                 140                 


Ser Gly Pro Gly Arg Phe Pro Val Pro Ser Pro Gly His Arg Ser Gly 
145                 150                 155                 160 


Pro Pro Glu Pro Gln Arg Asn Arg Met Pro Pro Pro Arg Pro Asp Val 
                165                 170                 175     


Gly Ser Lys Pro Asp Ser Ile Pro Pro Pro Val Pro Ser Thr Pro Arg 
            180                 185                 190         


Pro Ile Gln Ser Ser Pro His Asn Arg Gly Ser Pro Pro Val Pro Gly 
        195                 200                 205             


Gly Pro Arg Gln Pro Ser Pro Gly Pro Thr Pro Pro Pro Phe Pro Gly 
    210                 215                 220                 


Asn Arg Gly Thr Ala Leu Gly Gly Gly Ser Ile Arg Gln Ser Pro Leu 
225                 230                 235                 240 


Ser Ser Ser Ser Pro Phe Ser Asn Arg Pro Pro Leu Pro Pro Thr Pro 
                245                 250                 255     


Ser Arg Ala Leu Asp Asp Lys Pro Pro Pro Pro Pro Pro Pro Val Gly 
            260                 265                 270         


Asn Arg Pro Ser Ile His Arg Glu Ala Val Pro Pro Pro Pro Pro Gln 
        275                 280                 285             


Asn Asn Lys Pro Pro Val Pro Ser Thr Pro Arg Pro Ser Ala Ser Ser 
    290                 295                 300                 


Gln Ala Pro Pro Pro Pro Pro Pro Pro Ser Arg Pro Gly Pro Pro Pro 
305                 310                 315                 320 


Leu Pro Pro Ser Ser Ser Gly Asn Asp Glu Thr Pro Arg Leu Pro Gln 
                325                 330                 335     


Arg Asn Leu Ser Leu Ser Ser Ser Thr Pro Pro Leu Pro Ser Pro Gly 
            340                 345                 350         


Arg Ser Gly Pro Leu Pro Pro Pro Pro Ser Glu Arg Pro Pro Pro Pro 
        355                 360                 365             


Val Arg Asp Pro Pro Gly Arg Ser Gly Pro Leu Pro Pro Pro Pro Pro 
    370                 375                 380                 


Val Ser Arg Asn Gly Ser Thr Ser Arg Ala Leu Pro Ala Thr Pro Gln 
385                 390                 395                 400 


Leu Pro Ser Arg Ser Gly Val Asp Ser Pro Arg Ser Gly Pro Arg Pro 
                405                 410                 415     


Pro Leu Pro Pro Asp Arg Pro Ser Ala Gly Ala Pro Pro Pro Pro Pro 
            420                 425                 430         


Pro Ser Thr Ser Ile Arg Asn Gly Phe Gln Asp Ser Pro Cys Glu Asp 
        435                 440                 445             


Glu Trp Glu Ser Arg Phe Tyr Phe His Pro Ile Ser Asp Leu Pro Pro 
    450                 455                 460                 


Pro Glu Pro Tyr Val Gln Thr Thr Lys Ser Tyr Pro Ser Lys Leu Ala 
465                 470                 475                 480 


Arg Asn Glu Ser Arg Ser Gly Ser Asn Arg Arg Glu Arg Gly Ala Pro 
                485                 490                 495     


Pro Leu Pro Pro Ile Pro Arg 
            500             


<210>  8853
<211>  1710
<212>  DNA
<213>  Homosapiens

<400>  8853
aatgagaaga agcccttagc ctaatgaagc gataagattt atcagcaaga ctgttgaacg     60

cataactgcc caagatgcct gtccctcccc ctccagcacc cccgccgccc ccgacgtttg    120

cactggccaa tacagagaag cctaccttga ataagacaga gcaggctggg agaaatgctc    180

tcctttctga tatcagcaaa gggaagaaac taaagaagac ggtcaccaat gacagaagtg    240

caccaatact ggacaaacct aaaggagctg gtgctggagg cggtggtggt ggctttggtg    300

gaggcggcgg atttggcgga ggaggtggtg gcggaggcgg tggaagtttt ggagggggcg    360

gacctccagg tctgggagga ttgttccagg ctggaatgcc gaagctgaga tccacggcca    420

acagggataa tgattctgga ggaagccgac caccattgtt gccaccggga ggaagatcca    480

catctgcgaa acccttttca cccccaagtg gcccagggag gtttcctgtg ccttctccag    540

gccacagaag tggtccccca gagcctcaga ggaaccgaat gccgccccca aggcccgacg    600

tgggctcaaa gcctgatagc attcctcctc cagtacctag tactccaaga cccattcaat    660

caagtccgca caaccggggg tccccaccag tgcccggagg ccccaggcag cccagccccg    720

ggcccactcc tccccctttc cctggaaacc gcggcactgc tttgggagga ggctcaatac    780

gtcagtcccc cttgagctcc tcctcgccct tctccaaccg gcctcccctg ccgcctaccc    840

ccagcagggc cttggatgac aaaccccctc caccacctcc tccagtgggc aacaggccct    900

ccatccacag ggaagcggtt ccccctcctc ctcctcagaa caacaagcct ccagtgcctt    960

ccactccgcg gccttcggcc tcctcacagg ccccacctcc gccgccacct cccagcaggc   1020

ccgggccgcc tcctctgcct ccaagttcca gcggcaatga cgaaacccca agactcccac   1080

agcggaatct gtccctcagt tcgtccacgc ccccgttacc ttcgccagga cgttcaggtc   1140

ctcttcctcc cccgcccagt gagagacccc cacctccagt gagggacccg ccaggccgat   1200

caggtatgac aagacgtgga gtgagttgct tccaaaaccc agcctgccca aatgtaccaa   1260

taatcctgtc agtcaagata gtctaacaaa agcaggcata agtaaactca gactgctttg   1320

tgcttttaag tggcacacga cacgtgtgat cgtgacctcg tgtaaacccc gggggaaagt   1380

gggaccaata tttctgttgg tgttttagag atgaggacac tgagtagcta ataaagttaa   1440

atggtcacga gctagttaat aaagaagagg caagaacttt catcttccat ctctgaagtg   1500

tacttgccag tccactaccc tgcctcccta gagagaattt cggcggtctt aattgggaaa   1560

ataagtcccc acctcccgca ggagggctct gttattccaa caagagggga agttcttcaa   1620

gagctaatga acttctcctg tacttctctc ttcattcgcc aggctttgag gccatttccc   1680

tattcattaa agactaatgt ttaaaaagtc                                    1710


<210>  8854
<211>  403
<212>  PRT
<213>  Homosapiens

<400>  8854

Met Pro Val Pro Pro Pro Pro Ala Pro Pro Pro Pro Pro Thr Phe Ala 
1               5                   10                  15      


Leu Ala Asn Thr Glu Lys Pro Thr Leu Asn Lys Thr Glu Gln Ala Gly 
            20                  25                  30          


Arg Asn Ala Leu Leu Ser Asp Ile Ser Lys Gly Lys Lys Leu Lys Lys 
        35                  40                  45              


Thr Val Thr Asn Asp Arg Ser Ala Pro Ile Leu Asp Lys Pro Lys Gly 
    50                  55                  60                  


Ala Gly Ala Gly Gly Gly Gly Gly Gly Phe Gly Gly Gly Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Phe Gly Gly Gly Gly 
                85                  90                  95      


Pro Pro Gly Leu Gly Gly Leu Phe Gln Ala Gly Met Pro Lys Leu Arg 
            100                 105                 110         


Ser Thr Ala Asn Arg Asp Asn Asp Ser Gly Gly Ser Arg Pro Pro Leu 
        115                 120                 125             


Leu Pro Pro Gly Gly Arg Ser Thr Ser Ala Lys Pro Phe Ser Pro Pro 
    130                 135                 140                 


Ser Gly Pro Gly Arg Phe Pro Val Pro Ser Pro Gly His Arg Ser Gly 
145                 150                 155                 160 


Pro Pro Glu Pro Gln Arg Asn Arg Met Pro Pro Pro Arg Pro Asp Val 
                165                 170                 175     


Gly Ser Lys Pro Asp Ser Ile Pro Pro Pro Val Pro Ser Thr Pro Arg 
            180                 185                 190         


Pro Ile Gln Ser Ser Pro His Asn Arg Gly Ser Pro Pro Val Pro Gly 
        195                 200                 205             


Gly Pro Arg Gln Pro Ser Pro Gly Pro Thr Pro Pro Pro Phe Pro Gly 
    210                 215                 220                 


Asn Arg Gly Thr Ala Leu Gly Gly Gly Ser Ile Arg Gln Ser Pro Leu 
225                 230                 235                 240 


Ser Ser Ser Ser Pro Phe Ser Asn Arg Pro Pro Leu Pro Pro Thr Pro 
                245                 250                 255     


Ser Arg Ala Leu Asp Asp Lys Pro Pro Pro Pro Pro Pro Pro Val Gly 
            260                 265                 270         


Asn Arg Pro Ser Ile His Arg Glu Ala Val Pro Pro Pro Pro Pro Gln 
        275                 280                 285             


Asn Asn Lys Pro Pro Val Pro Ser Thr Pro Arg Pro Ser Ala Ser Ser 
    290                 295                 300                 


Gln Ala Pro Pro Pro Pro Pro Pro Pro Ser Arg Pro Gly Pro Pro Pro 
305                 310                 315                 320 


Leu Pro Pro Ser Ser Ser Gly Asn Asp Glu Thr Pro Arg Leu Pro Gln 
                325                 330                 335     


Arg Asn Leu Ser Leu Ser Ser Ser Thr Pro Pro Leu Pro Ser Pro Gly 
            340                 345                 350         


Arg Ser Gly Pro Leu Pro Pro Pro Pro Ser Glu Arg Pro Pro Pro Pro 
        355                 360                 365             


Val Arg Asp Pro Pro Gly Arg Ser Gly Met Thr Arg Arg Gly Val Ser 
    370                 375                 380                 


Cys Phe Gln Asn Pro Ala Cys Pro Asn Val Pro Ile Ile Leu Ser Val 
385                 390                 395                 400 


Lys Ile Val 
            


<210>  8855
<211>  1722
<212>  DNA
<213>  Homosapiens

<400>  8855
aggggaactc gagaagttgg ttgttttcag cagattaaaa caatacagat ttatcagcaa     60

gactgttgaa cgcataactg cccaagatgc ctgtccctcc ccctccagca cccccgccgc    120

ccccgacgtt tgcactggcc aatacagaga agcctacctt gaataagaca gagcaggctg    180

ggagaaatgc tctcctttct gatatcagca aagggaagaa actaaagaag acggtcacca    240

atgacagaag tgcaccaata ctggacaaac ctaaaggagc tggtgctgga ggcggtggtg    300

gtggctttgg tggaggcggc ggatttggcg gaggaggtgg tggcggaggc ggtggaagtt    360

ttggaggggg cggacctcca ggtctgggag gattgttcca ggctggaatg ccgaagctga    420

gatccacggc caacagggat aatgattctg gaggaagccg accaccattg ttgccaccgg    480

gaggaagatc cacatctgcg aaaccctttt cacccccaag tggcccaggg aggtttcctg    540

tgccttctcc aggccacaga agtggtcccc cagagcctca gaggaaccga atgccgcccc    600

caaggcccga cgtgggctca aagcctgata gcattcctcc tccagtacct agtactccaa    660

gacccattca atcaagtccg cacaaccggg ggtccccacc agtgcccgga ggccccaggc    720

agcccagccc cgggcccact cctccccctt tccctggaaa ccgcggcact gctttgggag    780

gaggctcaat acgtcagtcc cccttgagct cctcctcgcc cttctccaac cggcctcccc    840

tgccgcctac ccccagcagg gccttggatg acaaaccccc tccaccacct cctccagtgg    900

gcaacaggcc ctccatccac agggaagcgg ttccccctcc tcctcctcag aacaacaagc    960

ctccagtgcc ttccactccg cggccttcgg cctcctcaca ggccccacct ccgccgccac   1020

ctcccagcag gcccgggccg cctcctctgc ctccaagttc cagcggcaat gacgaaaccc   1080

caagactccc acagcggaat ctgtccctca gttcgtccac gcccccgtta ccttcgccag   1140

gacgttcagg tcctcttcct cccccgccca gtgagagacc cccacctcca gtgagggacc   1200

cgccaggccg atcaggtatg acaagacgtg gagtgagttg cttccaaaac ccagcctgcc   1260

caaatgtacc aataatcctg tcagtcaaga tagtctaaca aaagcaggca taagtaaact   1320

cagactgctt tgtgctttta agtggcacac gacacgtgtg atcgtgacct cgtgtaaacc   1380

ccgggggaaa gtgggaccaa tatttctgtt ggtgttttag agatgaggac actgagtagc   1440

taataaagtt aaatggtcac gagctagtta ataaagaaga ggcaagaact ttcatcttcc   1500

atctctgaag tgtacttgcc agtccactac cctgcctccc tagagagaat ttcggcggtc   1560

ttaattggga aaataagtcc ccacctcccg caggagggct ctgttattcc aacaagaggg   1620

gaagttcttc aagagctaat gaacttctcc tgtacttctc tcttcattcg ccaggctttg   1680

aggccatttc cctattcatt aaagactaat gtttaaaaag tc                      1722


<210>  8856
<211>  403
<212>  PRT
<213>  Homosapiens

<400>  8856

Met Pro Val Pro Pro Pro Pro Ala Pro Pro Pro Pro Pro Thr Phe Ala 
1               5                   10                  15      


Leu Ala Asn Thr Glu Lys Pro Thr Leu Asn Lys Thr Glu Gln Ala Gly 
            20                  25                  30          


Arg Asn Ala Leu Leu Ser Asp Ile Ser Lys Gly Lys Lys Leu Lys Lys 
        35                  40                  45              


Thr Val Thr Asn Asp Arg Ser Ala Pro Ile Leu Asp Lys Pro Lys Gly 
    50                  55                  60                  


Ala Gly Ala Gly Gly Gly Gly Gly Gly Phe Gly Gly Gly Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Phe Gly Gly Gly Gly 
                85                  90                  95      


Pro Pro Gly Leu Gly Gly Leu Phe Gln Ala Gly Met Pro Lys Leu Arg 
            100                 105                 110         


Ser Thr Ala Asn Arg Asp Asn Asp Ser Gly Gly Ser Arg Pro Pro Leu 
        115                 120                 125             


Leu Pro Pro Gly Gly Arg Ser Thr Ser Ala Lys Pro Phe Ser Pro Pro 
    130                 135                 140                 


Ser Gly Pro Gly Arg Phe Pro Val Pro Ser Pro Gly His Arg Ser Gly 
145                 150                 155                 160 


Pro Pro Glu Pro Gln Arg Asn Arg Met Pro Pro Pro Arg Pro Asp Val 
                165                 170                 175     


Gly Ser Lys Pro Asp Ser Ile Pro Pro Pro Val Pro Ser Thr Pro Arg 
            180                 185                 190         


Pro Ile Gln Ser Ser Pro His Asn Arg Gly Ser Pro Pro Val Pro Gly 
        195                 200                 205             


Gly Pro Arg Gln Pro Ser Pro Gly Pro Thr Pro Pro Pro Phe Pro Gly 
    210                 215                 220                 


Asn Arg Gly Thr Ala Leu Gly Gly Gly Ser Ile Arg Gln Ser Pro Leu 
225                 230                 235                 240 


Ser Ser Ser Ser Pro Phe Ser Asn Arg Pro Pro Leu Pro Pro Thr Pro 
                245                 250                 255     


Ser Arg Ala Leu Asp Asp Lys Pro Pro Pro Pro Pro Pro Pro Val Gly 
            260                 265                 270         


Asn Arg Pro Ser Ile His Arg Glu Ala Val Pro Pro Pro Pro Pro Gln 
        275                 280                 285             


Asn Asn Lys Pro Pro Val Pro Ser Thr Pro Arg Pro Ser Ala Ser Ser 
    290                 295                 300                 


Gln Ala Pro Pro Pro Pro Pro Pro Pro Ser Arg Pro Gly Pro Pro Pro 
305                 310                 315                 320 


Leu Pro Pro Ser Ser Ser Gly Asn Asp Glu Thr Pro Arg Leu Pro Gln 
                325                 330                 335     


Arg Asn Leu Ser Leu Ser Ser Ser Thr Pro Pro Leu Pro Ser Pro Gly 
            340                 345                 350         


Arg Ser Gly Pro Leu Pro Pro Pro Pro Ser Glu Arg Pro Pro Pro Pro 
        355                 360                 365             


Val Arg Asp Pro Pro Gly Arg Ser Gly Met Thr Arg Arg Gly Val Ser 
    370                 375                 380                 


Cys Phe Gln Asn Pro Ala Cys Pro Asn Val Pro Ile Ile Leu Ser Val 
385                 390                 395                 400 


Lys Ile Val 
            


<210>  8857
<211>  810
<212>  DNA
<213>  Homosapiens

<400>  8857
agaaggacgt ctgcctctga ctcagtatgt cacatttaac aagaggccag agcttgtcca     60

aaatggctgt ccaaaaacga ccccacactt gcgttagaag atgatacctt tttcagggac    120

agttttctct cttggctcct gtcccgctgg ccctctgtct gcctgtgtcc ctgaccatgg    180

ctccctgcag taccctttaa cgatttatca gcaagactgt tgaacgcata actgcccaag    240

atgcctgtcc ctccccctcc agcacccccg ccgcccccga cgtttgcact ggccaataca    300

gagaagccta ccttgaataa gacagagcag gctgggagaa atgctctcct ttctgatatc    360

agcaaaggga agaaactaaa gaagacggtc accaatgaca gaagtgcacc aatactggac    420

aaacctaaag gagctggtgc tggaggcggt ggtggtggct ttggtggagg cggcggattt    480

ggcggaggag gtggtggcgg aggcggtgga agttttggag ggggcggacc tccaggtctg    540

ggaggattgt tccaggctgg aatgccgaag ctgagatcca cggccaacag ggataatggg    600

ttagctggag tgggaagaaa agggaggagc aaatagaact tgctggccct ggaaatctgc    660

ctggtgacct gacagattca gctttctttg tgaggtagcc cagctgtcta gtagagtaaa    720

tacttgtgag ccgcttttca aacacgatgg agcacatctt gtggaatatg attacaaatc    780

tcactaaatc tgaaaaagtg ttttgcatga                                     810


<210>  8858
<211>  131
<212>  PRT
<213>  Homosapiens

<400>  8858

Met Pro Val Pro Pro Pro Pro Ala Pro Pro Pro Pro Pro Thr Phe Ala 
1               5                   10                  15      


Leu Ala Asn Thr Glu Lys Pro Thr Leu Asn Lys Thr Glu Gln Ala Gly 
            20                  25                  30          


Arg Asn Ala Leu Leu Ser Asp Ile Ser Lys Gly Lys Lys Leu Lys Lys 
        35                  40                  45              


Thr Val Thr Asn Asp Arg Ser Ala Pro Ile Leu Asp Lys Pro Lys Gly 
    50                  55                  60                  


Ala Gly Ala Gly Gly Gly Gly Gly Gly Phe Gly Gly Gly Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Phe Gly Gly Gly Gly 
                85                  90                  95      


Pro Pro Gly Leu Gly Gly Leu Phe Gln Ala Gly Met Pro Lys Leu Arg 
            100                 105                 110         


Ser Thr Ala Asn Arg Asp Asn Gly Leu Ala Gly Val Gly Arg Lys Gly 
        115                 120                 125             


Arg Ser Lys 
    130     


<210>  8859
<211>  482
<212>  DNA
<213>  Homosapiens

<400>  8859
ctcagcttcg gcattccagc ctggaacaat cctcccagac ctggaggtcc gccccctcca     60

aaacttccac cgcctccgcc accacctcct ccgccaaatc cgccgcctcc accaaagcca    120

ccaccaccgc ctccagcacc agctccttta ggttctgtag aagaagagac acccgacaga    180

ctatgccccc tggtctggcc cagaaatgga ctggagaagc taaaaaagac actgctggac    240

ttgtcacagc cgccgggaaa caagaattaa gacagttcgg aagagtccca ttcaaagtgg    300

gcggtctaga aaatgaaaat tttaaattcc acagcagcaa cagcagctct catgtatgga    360

gaatctgctg gatccagggc tctatccttg cgtggtctct gactcctaag acagcggaag    420

ccagcatcgc tgtgctcatt tgatagactc agagaaatta aatcactccc taaaacaccc    480

tg                                                                   482


<210>  8860
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  8860

Met Pro Pro Gly Leu Ala Gln Lys Trp Thr Gly Glu Ala Lys Lys Asp 
1               5                   10                  15      


Thr Ala Gly Leu Val Thr Ala Ala Gly Lys Gln Glu Leu Arg Gln Phe 
            20                  25                  30          


Gly Arg Val Pro Phe Lys Val Gly Gly Leu Glu Asn Glu Asn Phe Lys 
        35                  40                  45              


Phe His Ser Ser Asn Ser Ser Ser His Val Trp Arg Ile Cys Trp Ile 
    50                  55                  60                  


Gln Gly Ser Ile Leu Ala Trp Ser Leu Thr Pro Lys Thr Ala Glu Ala 
65                  70                  75                  80  


Ser Ile Ala Val Leu Ile 
                85      


<210>  8861
<211>  593
<212>  DNA
<213>  Homosapiens

<400>  8861
acagaaggac gtctgcctct gactcagtat gtcacattta acaagaggcc agagcttgtc     60

caaaatggct gtccaaaaac gaccccacac ttgcgttaga agatgatacc tttttcaggg    120

acagttttct ctcttggctc ctgtcccgct ggccctctgt ctgcctgtgt ccctgaccat    180

ggctccctgc agtacccttt aacgatttat cagcaagact gttgaacgca taactgccca    240

agatgcctgt ccctccccct ccagcacccc cgccgccccc gacgtttgca ctggccaata    300

cagagaagcc taccttgaat aagacagagc aggctgggag aaatgctctc ctttctgata    360

tcagcaaagg gaagaaacta aagaagacgg tcaccaatga cagaagtgca ccaatactgg    420

acagtaagta aaaaaaggct atctaccatg gagaggaaca gtttatggcc taataatcaa    480

ccctaccctc accactcaat ttttatttta ttttattttt tggttaacaa cagctgcaaa    540

gctagcaaaa taagggactg tatcactccc tgtaggccgc agctttggct tgg           593


<210>  8862
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  8862

Met Pro Val Pro Pro Pro Pro Ala Pro Pro Pro Pro Pro Thr Phe Ala 
1               5                   10                  15      


Leu Ala Asn Thr Glu Lys Pro Thr Leu Asn Lys Thr Glu Gln Ala Gly 
            20                  25                  30          


Arg Asn Ala Leu Leu Ser Asp Ile Ser Lys Gly Lys Lys Leu Lys Lys 
        35                  40                  45              


Thr Val Thr Asn Asp Arg Ser Ala Pro Ile Leu Asp Ser Lys 
    50                  55                  60          


<210>  8863
<211>  611
<212>  DNA
<213>  Homosapiens

<400>  8863
ggctagaaga cagcagggga actcgagaag ttggttgttt tcagcagatt aaaacaatac     60

aggaaccaga aaatgacaag aagagttgca tttgtctatg aaagtgcata gaaagctttt    120

cctggaaaag aataaactgg gaaaagatga gtccttgaag tagaaccctg tcatagtgca    180

acaaactgaa tttaagaggc atctgttccc agcttataca acatccagta ccagttccac    240

agccaacaat ggatagattt ggtcgtcctt gaagcattta gagacctgta gaatgaactt    300

aacttctgaa aactgggtgc ggggccaata gaggggctgc tcaatacctc accagcctgc    360

tacgcggaag gctagatgga gggctgctaa aggaagagaa ctgctgttcc acctccgcct    420

cctccctgca gtgtggcttc ttaggcaaga gataccgctg gccctccata ttcacaagct    480

ctgcatctgt gggttcagcc aactatggat cgaaatatgc aacttcaaat tatcttcatt    540

caggaaggag aaccctgagt tcttctgggt tggatctaag catggaagcc agctaccgtg    600

ttaagagctg c                                                         611


<210>  8864
<211>  90
<212>  PRT
<213>  Homosapiens

<400>  8864

Arg Gly Cys Ser Ile Pro His Gln Pro Ala Thr Arg Lys Ala Arg Trp 
1               5                   10                  15      


Arg Ala Ala Lys Gly Arg Glu Leu Leu Phe His Leu Arg Leu Leu Pro 
            20                  25                  30          


Ala Val Trp Leu Leu Arg Gln Glu Ile Pro Leu Ala Leu His Ile His 
        35                  40                  45              


Lys Leu Cys Ile Cys Gly Phe Ser Gln Leu Trp Ile Glu Ile Cys Asn 
    50                  55                  60                  


Phe Lys Leu Ser Ser Phe Arg Lys Glu Asn Pro Glu Phe Phe Trp Val 
65                  70                  75                  80  


Gly Ser Lys His Gly Ser Gln Leu Pro Cys 
                85                  90  


<210>  8865
<211>  771
<212>  DNA
<213>  Homosapiens

<400>  8865
cagggaaggg attgcctatg tgcctgattg attttttact ctgccatttc aatttccctc     60

tatttcgtca tcagtcagaa ggttggtgct gtttaaaggg gaaaaaaaag ctctaagtgt    120

ccccttctcc caaaaaaagg aaccagaaaa tgacaagaag agttgcattt gtctatgaaa    180

gtgcatagaa agcttttcct ggaaaagaat aaactgggaa aagatgagtc cttgaagtag    240

aaccctgtca tagtgcaaca aactgaattt aagaggcatc tgttcccagc ttatacaaca    300

tccagtacca gttccacagc caacaatgga tagatttggt cgtccttgaa gcatttagag    360

acctgtagaa tgaacttaac ttctgaaaac tgggtgcggg gccaatagag gggctgctca    420

atacctcacc agcctgctac gcggaaggct agatggaggg ctgctaaagg aagagaactg    480

ctgttccacc tccgcctcct ccctgcagtg tggcttctta ggcaagagat accgctggcc    540

ctccatattc acaagctctg catctgtggg ttcagccaac tatggatcga aatatgcaac    600

ttcaaattat cttcattcag gaaggagaac cctgagttct tctgggttgg atctaagcat    660

gtaagactat tgagttacat ttgacttctg aagtcacttt ttgtctttac tttttagtca    720

gcttgtgaaa gcaaaaagca tcttattttt aaaataccta tgttagtacc c             771


<210>  8866
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  8866

Met Cys Leu Ile Asp Phe Leu Leu Cys His Phe Asn Phe Pro Leu Phe 
1               5                   10                  15      


Arg His Gln Ser Glu Gly Trp Cys Cys Leu Lys Gly Lys Lys Lys Leu 
            20                  25                  30          


<210>  8867
<211>  4683
<212>  DNA
<213>  Homosapiens

<400>  8867
ggccgcgggt cccggcggcg gggtgggcgg gggaggcagc gggtgacaga tgtactcctc     60

tgacagctct cagtatcagc ccagtggctc cctgccattg gctcagtgca atggaccggc    120

aacgccgctc actataataa cactcatgcc tgccagcagc agcaactccg agtgcaggcg    180

ccgagcgcgg gggatgctgc cgccgccgcc gcttctgctg ccgcgcgggc ggctcccgca    240

gccccgctcc gcccggccac cgcgcgggca ctgactcccg ctcggttccg tttcgccggc    300

ccggccccct cctaggctgg aatcctcccg cggggctcgt cgtcccgacg cgaatctgag    360

gagaaacagg agcgagagac tgaggggaga gcgcggcgag catgcggagg cgggggagcc    420

tcggcgctca ccacagaggg gtgcagtgag ccagtctcca gaggacgtgc cgggggtggc    480

tgcgtgccct cgtggcgggt tcccagccca ccgtcgccgg ccccggcgcg ctgcggctgt    540

gggcgcgggg tgcgtggaag cggcggctgc ggcggaggag gcggcggctg ccccatggag    600

tgttactaca ttgtcatcag ctccacgcat ctcagcaacg gacactttcg caacatcaag    660

ggagttttcc ggggccctct cagcaagaac gggaacaaaa ctctggacta tgctgagaag    720

gaaaatacca tagcaaaagc tctggaagat ctgaaggcaa atttttactg tgaactctgt    780

gacaagcagt actataagca ccaggagttt gacaatcaca ttaattcata tgaccatgct    840

cacaagcaga ggctcaagga actgaaacaa agggaatttg ctcgaaatgt agcatctaaa    900

tccaggaaag atgaaagaaa acaggaaaag gcactccaac gcctgcacaa gctggctgag    960

ctaagaaagg aaactgtatg tgctcctgga agtggcccca tgttcaaatc aacaactgtt   1020

actgtgagag aaaactgtaa tgaaatttcc caacgagttg ttgtggattc agttaataac   1080

cagcaagatt tcaaatatac tttgattcat agtgaagaga atactaaaga tgctaccact   1140

gttgctgaag atccagaaag tgcaaataat tatacagcaa aaaataacca agttggggat   1200

caagcccagg ggattcacag acacaaaatc ggcttttctt ttgcatttcc aaagaaagcg   1260

tccgtgaagc tagagtcctc agctgcagcc ttctctgaat acagtgatga tgcctcagtg   1320

ggaaaaggat ttagcagaaa aagtagattt gtccccagtg cttgtcatct tcaacaatct   1380

tcaccaacag atgtgctttt gagttctgag gagaaaacta actcttttca tccaccagag   1440

gcaatgtgca gagacaaaga aactgttcaa actcaagaga taaaagaagt ctctagtgaa   1500

aaagatgcat tattattacc ttcattttgc aagtttcaac ttcagttatc ttctgatgca   1560

gataattgtc aaaattcagt cccattagca gatcaaatac cactagagag tgttgttatt   1620

aatgaagaca tacctgttag tggtaacagt tttgagttgt taggaaataa atccacagtt   1680

cttgacatgt ctaatgattg catatctgtg caagctacca cagaggaaaa tgttaagcat   1740

aacgaggcat ccacaactga ggttgaaaat aaaaatggtc ccgagacatt ggccccttca   1800

aatactgaag aggttaacat aactatacat aagaaaacaa atttctgcaa aagacaatgt   1860

gagccatttg tacctgtcct taacaaacac agatctacag ttcttcagtg gccatcagaa   1920

atgctggttt atacaactac gaaaccatca atttcctata gctgtaatcc tctatgtttt   1980

gacttcaagt ctactaaagt aaataataat ctagataaaa ataagccaga cttaaaagat   2040

ctttgttctc agcagaagca ggaagacatt tgcatgggac cactttcaga ttacaaggat   2100

gtatctacag aaggactcac tgattatgaa attggaagta gcaaaaataa atgcagccaa   2160

gtcactcctc ttttggctga tgatattctc tccagtagtt gtgattctgg aaaaaatgag   2220

aacacaggtc agaggtataa aaacatttcc tgtaagatca gagaaacaga aaagtataat   2280

tttactaaaa gtcaaataaa acaggacact ctagatgaaa aatacaacaa aataaggttg   2340

aaagagaccc atgaatactg gttccataaa agtagaagaa agaaaaaaag aaaaaagtta   2400

tgtcagcatc atcatatgga gaaaaccaaa gaatcagaaa ctcgctgcaa aatggaagca   2460

gagaatagtt acactgaaaa tgctgggaaa tatctattgg aaccaatttc agaaaagcag   2520

tatttagctg cagagcaatt attagactca catcagttac ttgataaaag gcccaaatca   2580

gaatccatat ccttaagtga caatgaagaa atgtgtaaaa catggaatac tgaatacaac   2640

acttatgata ctatcagttc taaaaaccac tgtaaaaaga acacaatact tttaaatgga   2700

caatcaaatg caacaatgat acattctggg aaacataatt taacatattc tagaacttac   2760

tgttgttgga aaaccaaaat gtcaagctgt agtcaggatc acagaagctt agttcttcaa   2820

aatgatatga aacacatgag tcagaatcag gctgttaaaa gaggttacaa ttctgtcatg   2880

aatgaatcag aaagattcta tcgaaaacgt agacaacatt cacattctta ttcttcagat   2940

gaaagtttaa atcgacagaa tcatttacca gaagaatttt tgaggccacc aagtacttca   3000

gttgctccct gcaagcctaa aaagaaacgg aggcgaaaaa gaggcagatt ccaccccgga   3060

tttgaaactt tagaactcaa agaaaataca gattatcccg tgaaagacaa ttcttcctta   3120

aatcctctgg ataggttaat aagtgaagac aaaaaagaga aaatgaaacc acaagaagtt   3180

gcaaaaatcg aaaggaactc agaacaaaca aaccaattaa gaaacaaact gtctttccac   3240

cctaacaatc tccttccttc tgaaaccaat ggtgaaactg agcatttaga aatggagacc   3300

acttctggtg aattgtcaga tgtttccaat gatcccacca catctgtctg tgtagctagt   3360

gccccaacaa aagaagcaat tgacaatacc ctgcttgaac acaaagaaag aagtgagaat   3420

ataaatctta atgaaaagca aattcctttt caggtgccta atattgaaag gaactttaga   3480

cagtcacagc ctaaatccta tctttgccat tatgaactgg ctgaggccct tccacaagga   3540

aagatgaatg agacaccaac tgagtggctg cgttataatt caggaatcct taacacacaa   3600

ccaccattac cattcaaaga agcacatgtc agtggtcata cttttgtaac agctgagcaa   3660

atcctggctc cattagcttt accagagcaa gcattattga tcccactaga aaaccatgac   3720

aaattcaaaa atgtaccatg tgaggtctac cagcacattc tgcagccaaa catgctggcc   3780

aacaaggtta aatttacctt tcctccagct gccctcccac cccctagcac acctctgcag   3840

cctttgcctt tgcagcagtc cttatgttct acctctgtaa ccactatcca tcacactgtt   3900

ttgcagcagc acgctgcagc tgctgcagct gcagctgcag ccgcagctgc aggaaccttt   3960

aaagtgcttc agccacacca acagtttctt tcccaaatcc cagctctcac cagaacctca   4020

ttacctcagc tctcagtagg accagtagga ccgaggcttt gtcctgggaa ccagccaact   4080

tttgttgctc ctcctcagat gccaatcatt ccagcttccg ttcttcatcc tagccatctg   4140

gctttcccat ctttacccca tgcactcttt ccttcactgc tttccccaca ccctactgtc   4200

atccctttgc aacctctctt ctagtcatca ccataatggg aaaaaaatac tcttgtgaaa   4260

actattgcta tatgcgttaa gtgttcatct atgtgggtac atggctattt aactggtgga   4320

aataaactgg ccgatacatg gcgtcattgg tttgaaatca tttactgtaa gtgcaatgat   4380

gcaaataaat ccctaagttt ctgatatata atattattaa agcactgaat agtttgaaaa   4440

tcaatacaat atatgctata tattaaaatg atgtcttaag agtatgtata atgtacataa   4500

aatatattta tagtactcta atttatgttg taaagtatgc tcccttggtt tttcttaatc   4560

tttgtgtatt tgcacctatt taatgtttag acaaagctga tggcactatg ttttgtatca   4620

tgttccttga aactgtaaat tcagtgaaaa atatctcttg caataaattt ttgttaacta   4680

ttt                                                                 4683


<210>  8868
<211>  1209
<212>  PRT
<213>  Homosapiens

<400>  8868

Met Glu Cys Tyr Tyr Ile Val Ile Ser Ser Thr His Leu Ser Asn Gly 
1               5                   10                  15      


His Phe Arg Asn Ile Lys Gly Val Phe Arg Gly Pro Leu Ser Lys Asn 
            20                  25                  30          


Gly Asn Lys Thr Leu Asp Tyr Ala Glu Lys Glu Asn Thr Ile Ala Lys 
        35                  40                  45              


Ala Leu Glu Asp Leu Lys Ala Asn Phe Tyr Cys Glu Leu Cys Asp Lys 
    50                  55                  60                  


Gln Tyr Tyr Lys His Gln Glu Phe Asp Asn His Ile Asn Ser Tyr Asp 
65                  70                  75                  80  


His Ala His Lys Gln Arg Leu Lys Glu Leu Lys Gln Arg Glu Phe Ala 
                85                  90                  95      


Arg Asn Val Ala Ser Lys Ser Arg Lys Asp Glu Arg Lys Gln Glu Lys 
            100                 105                 110         


Ala Leu Gln Arg Leu His Lys Leu Ala Glu Leu Arg Lys Glu Thr Val 
        115                 120                 125             


Cys Ala Pro Gly Ser Gly Pro Met Phe Lys Ser Thr Thr Val Thr Val 
    130                 135                 140                 


Arg Glu Asn Cys Asn Glu Ile Ser Gln Arg Val Val Val Asp Ser Val 
145                 150                 155                 160 


Asn Asn Gln Gln Asp Phe Lys Tyr Thr Leu Ile His Ser Glu Glu Asn 
                165                 170                 175     


Thr Lys Asp Ala Thr Thr Val Ala Glu Asp Pro Glu Ser Ala Asn Asn 
            180                 185                 190         


Tyr Thr Ala Lys Asn Asn Gln Val Gly Asp Gln Ala Gln Gly Ile His 
        195                 200                 205             


Arg His Lys Ile Gly Phe Ser Phe Ala Phe Pro Lys Lys Ala Ser Val 
    210                 215                 220                 


Lys Leu Glu Ser Ser Ala Ala Ala Phe Ser Glu Tyr Ser Asp Asp Ala 
225                 230                 235                 240 


Ser Val Gly Lys Gly Phe Ser Arg Lys Ser Arg Phe Val Pro Ser Ala 
                245                 250                 255     


Cys His Leu Gln Gln Ser Ser Pro Thr Asp Val Leu Leu Ser Ser Glu 
            260                 265                 270         


Glu Lys Thr Asn Ser Phe His Pro Pro Glu Ala Met Cys Arg Asp Lys 
        275                 280                 285             


Glu Thr Val Gln Thr Gln Glu Ile Lys Glu Val Ser Ser Glu Lys Asp 
    290                 295                 300                 


Ala Leu Leu Leu Pro Ser Phe Cys Lys Phe Gln Leu Gln Leu Ser Ser 
305                 310                 315                 320 


Asp Ala Asp Asn Cys Gln Asn Ser Val Pro Leu Ala Asp Gln Ile Pro 
                325                 330                 335     


Leu Glu Ser Val Val Ile Asn Glu Asp Ile Pro Val Ser Gly Asn Ser 
            340                 345                 350         


Phe Glu Leu Leu Gly Asn Lys Ser Thr Val Leu Asp Met Ser Asn Asp 
        355                 360                 365             


Cys Ile Ser Val Gln Ala Thr Thr Glu Glu Asn Val Lys His Asn Glu 
    370                 375                 380                 


Ala Ser Thr Thr Glu Val Glu Asn Lys Asn Gly Pro Glu Thr Leu Ala 
385                 390                 395                 400 


Pro Ser Asn Thr Glu Glu Val Asn Ile Thr Ile His Lys Lys Thr Asn 
                405                 410                 415     


Phe Cys Lys Arg Gln Cys Glu Pro Phe Val Pro Val Leu Asn Lys His 
            420                 425                 430         


Arg Ser Thr Val Leu Gln Trp Pro Ser Glu Met Leu Val Tyr Thr Thr 
        435                 440                 445             


Thr Lys Pro Ser Ile Ser Tyr Ser Cys Asn Pro Leu Cys Phe Asp Phe 
    450                 455                 460                 


Lys Ser Thr Lys Val Asn Asn Asn Leu Asp Lys Asn Lys Pro Asp Leu 
465                 470                 475                 480 


Lys Asp Leu Cys Ser Gln Gln Lys Gln Glu Asp Ile Cys Met Gly Pro 
                485                 490                 495     


Leu Ser Asp Tyr Lys Asp Val Ser Thr Glu Gly Leu Thr Asp Tyr Glu 
            500                 505                 510         


Ile Gly Ser Ser Lys Asn Lys Cys Ser Gln Val Thr Pro Leu Leu Ala 
        515                 520                 525             


Asp Asp Ile Leu Ser Ser Ser Cys Asp Ser Gly Lys Asn Glu Asn Thr 
    530                 535                 540                 


Gly Gln Arg Tyr Lys Asn Ile Ser Cys Lys Ile Arg Glu Thr Glu Lys 
545                 550                 555                 560 


Tyr Asn Phe Thr Lys Ser Gln Ile Lys Gln Asp Thr Leu Asp Glu Lys 
                565                 570                 575     


Tyr Asn Lys Ile Arg Leu Lys Glu Thr His Glu Tyr Trp Phe His Lys 
            580                 585                 590         


Ser Arg Arg Lys Lys Lys Arg Lys Lys Leu Cys Gln His His His Met 
        595                 600                 605             


Glu Lys Thr Lys Glu Ser Glu Thr Arg Cys Lys Met Glu Ala Glu Asn 
    610                 615                 620                 


Ser Tyr Thr Glu Asn Ala Gly Lys Tyr Leu Leu Glu Pro Ile Ser Glu 
625                 630                 635                 640 


Lys Gln Tyr Leu Ala Ala Glu Gln Leu Leu Asp Ser His Gln Leu Leu 
                645                 650                 655     


Asp Lys Arg Pro Lys Ser Glu Ser Ile Ser Leu Ser Asp Asn Glu Glu 
            660                 665                 670         


Met Cys Lys Thr Trp Asn Thr Glu Tyr Asn Thr Tyr Asp Thr Ile Ser 
        675                 680                 685             


Ser Lys Asn His Cys Lys Lys Asn Thr Ile Leu Leu Asn Gly Gln Ser 
    690                 695                 700                 


Asn Ala Thr Met Ile His Ser Gly Lys His Asn Leu Thr Tyr Ser Arg 
705                 710                 715                 720 


Thr Tyr Cys Cys Trp Lys Thr Lys Met Ser Ser Cys Ser Gln Asp His 
                725                 730                 735     


Arg Ser Leu Val Leu Gln Asn Asp Met Lys His Met Ser Gln Asn Gln 
            740                 745                 750         


Ala Val Lys Arg Gly Tyr Asn Ser Val Met Asn Glu Ser Glu Arg Phe 
        755                 760                 765             


Tyr Arg Lys Arg Arg Gln His Ser His Ser Tyr Ser Ser Asp Glu Ser 
    770                 775                 780                 


Leu Asn Arg Gln Asn His Leu Pro Glu Glu Phe Leu Arg Pro Pro Ser 
785                 790                 795                 800 


Thr Ser Val Ala Pro Cys Lys Pro Lys Lys Lys Arg Arg Arg Lys Arg 
                805                 810                 815     


Gly Arg Phe His Pro Gly Phe Glu Thr Leu Glu Leu Lys Glu Asn Thr 
            820                 825                 830         


Asp Tyr Pro Val Lys Asp Asn Ser Ser Leu Asn Pro Leu Asp Arg Leu 
        835                 840                 845             


Ile Ser Glu Asp Lys Lys Glu Lys Met Lys Pro Gln Glu Val Ala Lys 
    850                 855                 860                 


Ile Glu Arg Asn Ser Glu Gln Thr Asn Gln Leu Arg Asn Lys Leu Ser 
865                 870                 875                 880 


Phe His Pro Asn Asn Leu Leu Pro Ser Glu Thr Asn Gly Glu Thr Glu 
                885                 890                 895     


His Leu Glu Met Glu Thr Thr Ser Gly Glu Leu Ser Asp Val Ser Asn 
            900                 905                 910         


Asp Pro Thr Thr Ser Val Cys Val Ala Ser Ala Pro Thr Lys Glu Ala 
        915                 920                 925             


Ile Asp Asn Thr Leu Leu Glu His Lys Glu Arg Ser Glu Asn Ile Asn 
    930                 935                 940                 


Leu Asn Glu Lys Gln Ile Pro Phe Gln Val Pro Asn Ile Glu Arg Asn 
945                 950                 955                 960 


Phe Arg Gln Ser Gln Pro Lys Ser Tyr Leu Cys His Tyr Glu Leu Ala 
                965                 970                 975     


Glu Ala Leu Pro Gln Gly Lys Met Asn Glu Thr Pro Thr Glu Trp Leu 
            980                 985                 990         


Arg Tyr Asn Ser Gly Ile Leu Asn  Thr Gln Pro Pro Leu  Pro Phe Lys 
        995                 1000                 1005             


Glu Ala  His Val Ser Gly His  Thr Phe Val Thr Ala  Glu Gln Ile 
    1010                 1015                 1020             


Leu Ala  Pro Leu Ala Leu Pro  Glu Gln Ala Leu Leu  Ile Pro Leu 
    1025                 1030                 1035             


Glu Asn  His Asp Lys Phe Lys  Asn Val Pro Cys Glu  Val Tyr Gln 
    1040                 1045                 1050             


His Ile  Leu Gln Pro Asn Met  Leu Ala Asn Lys Val  Lys Phe Thr 
    1055                 1060                 1065             


Phe Pro  Pro Ala Ala Leu Pro  Pro Pro Ser Thr Pro  Leu Gln Pro 
    1070                 1075                 1080             


Leu Pro  Leu Gln Gln Ser Leu  Cys Ser Thr Ser Val  Thr Thr Ile 
    1085                 1090                 1095             


His His  Thr Val Leu Gln Gln  His Ala Ala Ala Ala  Ala Ala Ala 
    1100                 1105                 1110             


Ala Ala  Ala Ala Ala Ala Gly  Thr Phe Lys Val Leu  Gln Pro His 
    1115                 1120                 1125             


Gln Gln  Phe Leu Ser Gln Ile  Pro Ala Leu Thr Arg  Thr Ser Leu 
    1130                 1135                 1140             


Pro Gln  Leu Ser Val Gly Pro  Val Gly Pro Arg Leu  Cys Pro Gly 
    1145                 1150                 1155             


Asn Gln  Pro Thr Phe Val Ala  Pro Pro Gln Met Pro  Ile Ile Pro 
    1160                 1165                 1170             


Ala Ser  Val Leu His Pro Ser  His Leu Ala Phe Pro  Ser Leu Pro 
    1175                 1180                 1185             


His Ala  Leu Phe Pro Ser Leu  Leu Ser Pro His Pro  Thr Val Ile 
    1190                 1195                 1200             


Pro Leu  Gln Pro Leu Phe 
    1205                 


<210>  8869
<211>  817
<212>  DNA
<213>  Homosapiens

<400>  8869
ggactatgct gagaaggaaa ataccatagc aaaagctctg gaagatctga aggcaaattt     60

ttactgtgaa ctctgtgaca agcagtacta taagcaccag gagtttgaca atcacattaa    120

ttcatatgac catgctcaca agcaggtggg attctaagat ggccatcaag attaccagta    180

cccctaatgt atacacctca tcaatcagac attaatttat tttctactgt gaagtaattt    240

tgcgatacaa ttaagatctc aaatcagcta agtttaacat tgtcccattg gggctaatct    300

aattccctga gctctttaaa aatgtggagt tttctgtggc tgctctaaaa agaggaagcc    360

agagatttga agcatgagaa gaatttgaca catgagaaat tccccagtgc tggctttgaa    420

gatggaagga gcaacataac aaagaatgag gcagcatgca gtagataagg gagatctctg    480

actgacagcc aacaagaaaa caggtatctc agacctccag ccatgaagaa ctgaatcctg    540

ccaacaacat gagtaagctc agaaacagat atttctccag agcttccaga tgagaaccca    600

gtctttgatc ccagtcatat ataccctgag gagagaacac agccactgtg cctcactttt    660

catctatgaa actgtgacaa tctatgaaac atggattatt ttaagccatt tagtttctgt    720

taatttttta cacagcagta gaaaactagc acattctctc accatcctgt atttgttatg    780

ttaaactcta aaaattactt ctacattctc atgtcat                             817


<210>  8870
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  8870

Met Arg Thr Gln Ser Leu Ile Pro Val Ile Tyr Thr Leu Arg Arg Glu 
1               5                   10                  15      


His Ser His Cys Ala Ser Leu Phe Ile Tyr Glu Thr Val Thr Ile Tyr 
            20                  25                  30          


Glu Thr Trp Ile Ile Leu Ser His Leu Val Ser Val Asn Phe Leu His 
        35                  40                  45              


Ser Ser Arg Lys Leu Ala His Ser Leu Thr Ile Leu Tyr Leu Leu Cys 
    50                  55                  60                  


<210>  8871
<211>  615
<212>  DNA
<213>  Homosapiens

<400>  8871
tgcagggttg cctagaagcc gatgatcact gtaaagttcc ccaatgaatt aagtttgggc     60

caggagatac taaaggatac aaaaatggca gactcactgc tgttctggag gttgtgaaaa    120

atctttttaa aaattatcat gaagaaaatt caggtctcca aatgtacctc tactcgatta    180

actaaggaaa agctgtttgt aatctaggga ccgcaatagc tgtcacaatt aatactgagt    240

atgtgctgtt ctatcatttt tggcaaggat tggtgtttca tcatttagac acatcaggta    300

cttacattgc agtgtcatat aatttaaatt ggcattgttt aaaatgatga aaaaataaca    360

aagtaccaat cagaaactaa attttagtac agtgggaagg attcatccat tgaattggat    420

tgatagaaga tgagacagca atttaataga gttttgttca tcttttcctt tcttggttga    480

ctaacactga catttttgag gtcttttatt tctacagaac gttctctgca gtctcctctt    540

caaatacggc tcttggctat gcttgtgaat tttgtgaata tacaattatt tcaaattaaa    600

tactaactga atgtg                                                     615


<210>  8872
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  8872

Met Ile Thr Val Lys Phe Pro Asn Glu Leu Ser Leu Gly Gln Glu Ile 
1               5                   10                  15      


Leu Lys Asp Thr Lys Met Ala Asp Ser Leu Leu Phe Trp Arg Leu 
            20                  25                  30      


<210>  8873
<211>  446
<212>  DNA
<213>  Homosapiens

<400>  8873
aatgtagaca gaaacaaaca ggcaaccctg cagtggtagt agtggtgaca gcagcagcgg     60

caatgatgga agcctgcagg agccaagagt gtaagaaatg gaaaccgctt tctctatttt    120

ctctggagct atagattcag acggttatct taacagtctg caacaatata ctgagagaag    180

cactaacgaa actgcatttc tctgtcatgc tgtgccagct gtagtatgtg ggaaaccttg    240

tctctcccaa gtaccttctg tctctggcag ctccatgtaa acttcaggaa tggtcagtgc    300

tgagctttta gttgctgtat ccaccatctc cacagaccaa gacccagtga cttgcatttc    360

ttgcctccat gtccatggct tattttctcc ctactcagtt atgttatcct acttcattca    420

ccgatgttgt agacactgtt ctgaat                                         446


<210>  8874
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  8874

Met Glu Thr Ala Phe Ser Ile Phe Ser Gly Ala Ile Asp Ser Asp Gly 
1               5                   10                  15      


Tyr Leu Asn Ser Leu Gln Gln Tyr Thr Glu Arg Ser Thr Asn Glu Thr 
            20                  25                  30          


Ala Phe Leu Cys His Ala Val Pro Ala Val Val Cys Gly Lys Pro Cys 
        35                  40                  45              


Leu Ser Gln Val Pro Ser Val Ser Gly Ser Ser Met 
    50                  55                  60  


<210>  8875
<211>  421
<212>  DNA
<213>  Homosapiens

<400>  8875
tagaaagaag ttggaagagg aaacattagg aatttccttt caaactccaa tcaaaacagc     60

ccatttgaat atttttttaa aaaaattcca aaaattcttc ctgtgaggat gcattggcta    120

aagcaggtca aagttgctga agaggactaa gcgagcctct tggggaagat gatatcatct    180

gatctgtaca catgtcacat tcagaacatt ctgcatggct gctgctgagc tcccatctgt    240

cagatctcaa cagagagaac aaagactaga gatgtgagta attcaagaaa catccattta    300

ctagctgaaa aaacaaataa aattaggagg agccactttc ttcttgttac atgttactga    360

tacgtgttct acctggccat accacacatt acataaaatg tattcaacta ctttactgtc    420

a                                                                    421


<210>  8876
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  8876

Arg Lys Lys Leu Glu Glu Glu Thr Leu Gly Ile Ser Phe Gln Thr Pro 
1               5                   10                  15      


Ile Lys Thr Ala His Leu Asn Ile Phe Leu Lys Lys Phe Gln Lys Phe 
            20                  25                  30          


Phe Leu 
        


<210>  8877
<211>  2528
<212>  DNA
<213>  Homosapiens

<400>  8877
aatgcaagca gatgaagagg aaagaactga gcagcagtat ttcaggattc tcaataaggc     60

atcaatgaaa aaaggtcaaa actgtgatcc ctgctacttg ggaggctgag acacaagaat    120

tgcttgaatc caggaggcgg aggttgcagt gaaccaagat catgccactg aactccagcc    180

tgggtgacag agcaagagtc tgtctcaaaa aaaaaaaaaa gaaaagaaaa agatattgct    240

tagaaaagta acttgagtcc tgttgagcct aagtaaagga caataatgga agtttctagt    300

ctgcaaaata tgaagatgcc cctcagagac acagctgtgg gtgcctctca caagacagat    360

gttcaggaaa actgggctgt tgctctggaa ttttcaatga gttattttac ttgtttttgc    420

ctcagtttac agaaaataaa ctggcaacaa tatctccttg ttattgtgag gataaaataa    480

aaggtgtgac atttctattt taaatgtata aaatgccgaa aaattggagg caactggaag    540

gtacagtagt ggatgtgagg tagtaagggg gaaaaaagga tatgtaaatc acctaagatg    600

aaatagacat tcagaaggcc gtaacgtgaa gtgtgagtga cactgattcg ctaaaaatcc    660

tatatagtgt cttaaaacag cagcagtaac aacaacaaag tttatttgag aggaggaatt    720

ctggaaaaaa gcttctttca aaaaaaaaaa aagagtcttc tagtgctcag acagttcgtt    780

cctctgcaaa ggcgggttac tctgttgggg tccattatag ttctgaggat gaataggaca    840

ggacaaggag atggttcctg gcccctgttc tcctgccaca gatctgtccc acctcccagg    900

ctccatgcat acagtgacag agatggaaag cccagaacca gtccctttaa tgcacttatt    960

tgcaaaacaa gatgtcacta tgcagcagag tgacagtcct ttcccctgga actgtcccag   1020

agttctccaa gctgaagcca gggctacatt caccatctca gactcctgct gagctaagta   1080

accaccctct cctaccttct cttcaggagc cctggcaccc ttgctctggg gagagtttga   1140

agagcaacct gaaagttccc acagtttttc ctcaaatctg ggtttccatg agcatgggcc   1200

accagtcggg agagccacat gcctgccctt gcctggctca agactgtcac tctgtcagat   1260

tcatatcgct ctctgaccct tagccttcca gtctggatct tgaccttgaa ctggactctg   1320

taggaagttc ttaacattaa aggaagttat ttatctcttt tcaactaacc caagcacttt   1380

ctagcacctt ttagcagttt aagctctatg actccattgg ataaaatgct ggggagcagg   1440

acattgacac agtcacagaa tatcacacac ggaatcctca ttcattcccc cagggaaaca   1500

gcacctgtag aagacaaatc tggtagacac tactgtgaca ggtgatttta tatgtcagct   1560

tgactaggcc acaggatgtg tagacatttg tcaaattttt ttttatatgt ctgtgaggat   1620

gtttctggat gagattaaca ttgaatcagt agactgagta aagaagaccg ccctccccag   1680

tgggggtgtc cctcatccaa cctgtggaag ccctacatag aacaaaaagg ctgaacctcc   1740

cccaaaatac ggtgatctca agctgcctga cttctggtgc tggaacattg ttctttttct   1800

gccttccgac tcaaactgaa aatcagctca tcttgtatcc tgagtctgct ggcttccaga   1860

ctgaactata cattgactct cccaggtttc cagcttgcaa ctgctggtct tgggacttct   1920

cagcctccat aatcatgcat tagccaattt ctatatagat ctagaaattc atatatatat   1980

atgtgtgtgt gtgtgtgtat gtgtgtgtgt gtgtgtacgc atatatatac agtcatgaat   2040

cactgagcag tgggcatacc ttctgagaaa tgtgtcatta ggcactgtta tcattgtgtg   2100

aacatcatag tgtacttaca cacacctaga cggtatagcc tacaacacac ctaggctata   2160

tagtataact tgttgctggt agattacaaa cctgtacaac ctgttactgt actgaatact   2220

gtaggcaatt gtaaaacaat ggtaagtatt tgtgtatcta aacatagcta accatagaaa   2280

aggtacagta aaaatactgt ataagagata aaacatggtg tgcctgtata ggttgcttac   2340

cataaataaa gcttgcaggt tggaagttac tctgggtgag tcagtgagta aatgatgagt   2400

gaatgtgagg cccttggaca tcactgtacc ctactgtaga ctttataaac actgtacact   2460

taggttaccc taaatctatt ttaaaattgt tttctttctt caataataaa ttacccttag   2520

cttactgt                                                            2528


<210>  8878
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  8878

Met Gln Ala Asp Glu Glu Glu Arg Thr Glu Gln Gln Tyr Phe Arg Ile 
1               5                   10                  15      


Leu Asn Lys Ala Ser Met Lys Lys Gly Gln Asn Cys Asp Pro Cys Tyr 
            20                  25                  30          


Leu Gly Gly 
        35  


<210>  8879
<211>  1206
<212>  DNA
<213>  Homosapiens

<400>  8879
gtgaaggaga ctgagaagga acagtcaaag atattgcagg aagaccagta gtacatggaa     60

gtcaaaggag agagcatcaa gaaagagatg cgatgagtca acaagaagtt tacagcactg    120

agaaagacga gtcaacaaca gaaggaaaaa aatccagaga aaatggcact tgctgcattg    180

gaatgaaaga taatctgcag aaggacctgc tcagtggcaa taaacattgg cattcttgga    240

aacagtgttt gcctaagaat cttctgtctg cctttgttgc tttggccata ttatgataag    300

ggcatgactg gatttaccaa aatgggcatg attggatcta cttattctct tatcagacac    360

cttttcctag acaacatcct gaaacataag aataagcaca aaaatgaaca tattacatca    420

aacgtaccac tgagaagaat ggtaagttta acagtttccc acgtgggagg catattgacg    480

attacaattt taagttagca gaacaccagc tcacatggaa acagtctcct ccgtgaattc    540

tttctttggc tgacagacat gagatgttag ctgtctaaga agaccttcac accaacacct    600

tcttagaaga tattgtaaga taacaatcct tgagtggaac ctgaattctt tctaaacact    660

gcatgtagga aaacaagagg cagttcacac aatcacttaa cacctcttct taaaagtgaa    720

tccttgaagg agtggtgttc aaatatttaa gtacattaga tactttatac acgccacatc    780

caaaatgctc agtattccta atacatttca ttttctccca agttttaatg gttgatgcac    840

aatcacatta atttcctatt aatttctagg aatatgtaca cagtagcctt aggagaaaga    900

agataactat tactttacat ttttaactgt tttgttttca tgtccatgag agaaaaatta    960

aagtaagtta aaaaattaac tcagacactc tatttatttt taggaagaca tacacccccc   1020

acagggagac ttttacatgt tgtaataatg ttcacaaaca gctactcttt aagtgtaaca   1080

ctattctaag cctcttttcc tccattttat ttcatataca tttatgcatc tgcatgcata   1140

tataaccaca tgtatttata tttagtaggt atagtttatt acacataaat ctaaatatct   1200

atcata                                                              1206


<210>  8880
<211>  67
<212>  PRT
<213>  Homosapiens

<400>  8880

Met Ser Gln Gln Glu Val Tyr Ser Thr Glu Lys Asp Glu Ser Thr Thr 
1               5                   10                  15      


Glu Gly Lys Lys Ser Arg Glu Asn Gly Thr Cys Cys Ile Gly Met Lys 
            20                  25                  30          


Asp Asn Leu Gln Lys Asp Leu Leu Ser Gly Asn Lys His Trp His Ser 
        35                  40                  45              


Trp Lys Gln Cys Leu Pro Lys Asn Leu Leu Ser Ala Phe Val Ala Leu 
    50                  55                  60                  


Ala Ile Leu 
65          


<210>  8881
<211>  358
<212>  DNA
<213>  Homosapiens

<400>  8881
gggaggagaa agggaggaaa gggagtagag aaggccacac acaatcttaa attcaatatt     60

tcactcccgt taaagataag ctgtttataa gctccagtgt agggcatgta attctatgta    120

aaaactctgt ggttcctctt cccacatgta aatcatgatc actctacatt ctgctctctg    180

ggagccctca aggcaaagag acaacaagac tcgagaccac agaaaggact tatcacaagt    240

ctttgtggta gctgaggagt gccccctaca gactgatatg cacaatgcaa gcagatgaag    300

aggaaagaac tgagcagcag tatttcagga ttctcaataa ggcatcaatg aaaaaagg      358


<210>  8882
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  8882

Met Ile Thr Leu His Ser Ala Leu Trp Glu Pro Ser Arg Gln Arg Asp 
1               5                   10                  15      


Asn Lys Thr Arg Asp His Arg Lys Asp Leu Ser Gln Val Phe Val Val 
            20                  25                  30          


Ala Glu Glu Cys Pro Leu Gln Thr Asp Met His Asn Ala Ser Arg 
        35                  40                  45          


<210>  8883
<211>  3618
<212>  DNA
<213>  Homosapiens

<400>  8883
gcggccgccc ctccccgatt cccgccacct gccgcctggc caggtggaag gggcgctgcc     60

gcgagcctcc gggcctcagg gtgttccggg gagcggcgcc ccgggtctct gggcccaccc    120

gccccgggcg tcctccgaga gtgggggctg cgcccgcggg gtcagacacc tgttcggccc    180

ggcccggcgt ggtcgccggg ggccaggatg aaagtgaccg tgtgcttcgg caggacgggc    240

atcgtggtgc cctgcaagga gggccagctg cgcgtcggcg agctcaccca gcaggcgctg    300

cagcggtacc tgaagacccg ggagaagggt cctggttact gggtgaagat tcatcactta    360

gaatatacag atggaggaat cctggatcca gatgatgtct tggcagatgt tgttgaagat    420

aaagacaagc tgattgctgt gtttgaagaa caagaaccac tccacaagat tgagagcccc    480

agtggaaacc ctgcagatcg gcagagccca gatgcttttg agacagaagt ggccgcccaa    540

ctggccgcat ttaagccaat tggtggggag attgaagtaa ccccttctgc tctaaaacta    600

ggcactccac tgctggtgag gagaagcagt gacccagtgc caggcccacc tgctgatacc    660

cagccaagcg cttcacaccc tggtggccag agtctgaaac tggttgttcc agattccacg    720

cagaacttgg aagacagaga agttttgaat ggtgtacaga cagaactact aacttcgcca    780

agaactaagg acacattgag tgatatgaca agaacagtgg agatttctgg ggaaggaggc    840

ccattgggaa tacatgtagt gcccttcttt tcatctctga gtggaaggat tctaggactc    900

ttcatccgag gcattgaaga caacagcagg tccaagcggg agggactatt tcacgaaaat    960

gaatgtattg taaaaatcaa caatgtggat ctcgtagaca aaacctttgc tcaggctcaa   1020

gatgtcttcc gccaggcaat gaaatctcca agtgtgctcc tccacgtgct tcctccacaa   1080

aaccgtgaac agtatgaaaa gtcagtcatt ggctctctta acatttttgg taataatgat   1140

ggcgttttga aaaccaaagt gccgcctcct gtccatggaa aatcgggact aaagacagca   1200

aatctcacag gaaccgatag tcctgaaaca gatgcatcag cttccctgca acaaaacaag   1260

agtccccgag taccaaggct gggaggaaaa ccatcctctc cctcactctc gcctctcatg   1320

ggatttggca gcaataaaaa tgcaaagaaa attaagattg acctaaagaa aggccctgaa   1380

ggacttggtt tcactgtggt taccagagac tcttccatac atggtcccgg tcccattttt   1440

gtaaaaaaca ttttaccaaa gggagcagca ataaaagatg gccgcctaca atcaggggac   1500

agaattttgg aggtaaatgg gagagatgtc accggacgaa cccaggaaga gcttgtggcc   1560

atgctcagga gcaccaagca gggggagaca gcatcgctgg tcattgcccg ccaagaagga   1620

cattttctgc cccgagagtt gaaaggagaa cctgactgct gtgcactctc tctggagaca   1680

agcgagcagc tcacctttga gatccccctg aatgattcag gttctgctgg cctcggggtg   1740

agcttaaaag ggaacaaatc cagagaaact ggaacagact tggggatttt tatcaaatcc   1800

atcattcatg gaggcgctgc ttttaaggat ggtcgtctgc gaatgaatga ccagctgatt   1860

gcagttaatg gggaatctct tttgggaaag tccaaccacg aagctatgga aacacttagg   1920

cggtcaatgt ccatggaggg aaacatccga gggatgatcc agttggtgat tctgaggagg   1980

ccagagagac caatggagga tcctgcagag tgtggggcat tttccaagcc atgctttgag   2040

aactgtcaaa atgctgtaac cacctctagg cgaaatgata atagtatcct gcatccactt   2100

ggcacttgca gtccacaaga caaacagaaa ggtctattgc tgcccaatga cggatgggcc   2160

gagagtgaag ttccaccttc tccaacacca cattctgctc tgggattggg cctcgaagat   2220

tacagccaca gctctggggt ggattcagca gtatattttc cagatcagca catcaacttc   2280

agatctgtga caccggccag gcagcctgaa tcaattaatt tgaaagcctc gaagagcatg   2340

gaccttgtgc cagatgaaag caaggttcac tcattggctg gacaaaaatc ggacggtctg   2400

tctgataaga gctctcactc tggccaagga gctctgaatt gtgagtctgc ccctcagggg   2460

aattcggagc tagaggacat ggaaaataaa gccaggaaag tcaaaaaaac gaaagagaag   2520

gagaagaaaa aggaaaaggg caaattgaaa gtcaaggaga aaaagcgcaa agaggagaat   2580

gaagatccag aaaggaaaat aaagaagaag ggcttcggcg ccatgctgag atttggaaag   2640

aagaaagagg ataagggtgg aaaggctgag cagaaaggta ctctgaaaca tggtggcctg   2700

agagaagaag agctggagaa aatgaaagaa gagcgtgaaa ggattggagc aaaacatcag   2760

gagctaaggg aaaagcaggc aagaggtctt cttgattatg ctactggtgc aattggatca   2820

gtgtatgata tggatgatga tgaaatggac cccaattatg ccagagtgaa ccactttcgg   2880

gaaccatgca catcagcaaa tgtctttaga tctccatctc cccctcgagc tggaccattt   2940

ggttaccctc gggatggcca tccactgtct ccagaaagag accacttaga gggtctctat   3000

gccaaggtca acaagccata ccatccactg gttccagctg acagtggccg tcctacgggt   3060

ggaagcactg accgtatcca gaagttgcgg aaagagtatt atcaggctcg gagggaaggt   3120

ttccctttat atgaagacga cgaaggaaga gcaaggccat ctgagtatga cctactctgg   3180

gtgcctggaa ggggtccaga tgggaatgca cacaacctcc gctttgaagg gatggagagg   3240

cagtacgcat ccttacccag gggaggaccc gcagatcctg tagactatct gccagcagca   3300

cctcgggggc tctacaagga aagggagctt ccctattatc caggggctca tcctatgcac   3360

cctcccaaag ggagctatcc ccgccccaca gagctcaggg tggcagatct ccggtatcct   3420

cagcactacc cacccccgcc agctccccag cacaaaggac cctttcgaca agacgttccg   3480

ccttcccctc cccagcacca aagaatgcca gcctatcagg aaacaggcag accagggccc   3540

cgtgggggca gcccagacca gtacccttac cgaacccagg attcccggca gaagaacccc   3600

atgactgcag ccgtatag                                                 3618


<210>  8884
<211>  1136
<212>  PRT
<213>  Homosapiens

<400>  8884

Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Gly Pro Gly Tyr Trp Val Lys Ile 
        35                  40                  45              


His His Leu Glu Tyr Thr Asp Gly Gly Ile Leu Asp Pro Asp Asp Val 
    50                  55                  60                  


Leu Ala Asp Val Val Glu Asp Lys Asp Lys Leu Ile Ala Val Phe Glu 
65                  70                  75                  80  


Glu Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro Ala 
                85                  90                  95      


Asp Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln Leu 
            100                 105                 110         


Ala Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser Ala 
        115                 120                 125             


Leu Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro Val 
    130                 135                 140                 


Pro Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly Gly 
145                 150                 155                 160 


Gln Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu Asp 
                165                 170                 175     


Arg Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro Arg 
            180                 185                 190         


Thr Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser Gly 
        195                 200                 205             


Glu Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser Leu 
    210                 215                 220                 


Ser Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn Ser 
225                 230                 235                 240 


Arg Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val Lys 
                245                 250                 255     


Ile Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln Asp 
            260                 265                 270         


Val Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val Leu 
        275                 280                 285             


Pro Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser Leu 
    290                 295                 300                 


Asn Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro Pro 
305                 310                 315                 320 


Pro Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly Thr 
                325                 330                 335     


Asp Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys Ser 
            340                 345                 350         


Pro Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu Ser 
        355                 360                 365             


Pro Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys Ile 
    370                 375                 380                 


Asp Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr Arg 
385                 390                 395                 400 


Asp Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile Leu 
                405                 410                 415     


Pro Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp Arg 
            420                 425                 430         


Ile Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu Glu 
        435                 440                 445             


Leu Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser Leu 
    450                 455                 460                 


Val Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Lys Gly 
465                 470                 475                 480 


Glu Pro Asp Cys Cys Ala Leu Ser Leu Glu Thr Ser Glu Gln Leu Thr 
                485                 490                 495     


Phe Glu Ile Pro Leu Asn Asp Ser Gly Ser Ala Gly Leu Gly Val Ser 
            500                 505                 510         


Leu Lys Gly Asn Lys Ser Arg Glu Thr Gly Thr Asp Leu Gly Ile Phe 
        515                 520                 525             


Ile Lys Ser Ile Ile His Gly Gly Ala Ala Phe Lys Asp Gly Arg Leu 
    530                 535                 540                 


Arg Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu Leu Gly 
545                 550                 555                 560 


Lys Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met Ser Met 
                565                 570                 575     


Glu Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg Arg Pro 
            580                 585                 590         


Glu Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser Lys Pro 
        595                 600                 605             


Cys Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg Asn Asp 
    610                 615                 620                 


Asn Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp Lys Gln 
625                 630                 635                 640 


Lys Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu Val Pro 
                645                 650                 655     


Pro Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu Asp Tyr 
            660                 665                 670         


Ser His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp Gln His 
        675                 680                 685             


Ile Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser Ile Asn 
    690                 695                 700                 


Leu Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser Lys Val 
705                 710                 715                 720 


His Ser Leu Ala Gly Gln Lys Ser Asp Gly Leu Ser Asp Lys Ser Ser 
                725                 730                 735     


His Ser Gly Gln Gly Ala Leu Asn Cys Glu Ser Ala Pro Gln Gly Asn 
            740                 745                 750         


Ser Glu Leu Glu Asp Met Glu Asn Lys Ala Arg Lys Val Lys Lys Thr 
        755                 760                 765             


Lys Glu Lys Glu Lys Lys Lys Glu Lys Gly Lys Leu Lys Val Lys Glu 
    770                 775                 780                 


Lys Lys Arg Lys Glu Glu Asn Glu Asp Pro Glu Arg Lys Ile Lys Lys 
785                 790                 795                 800 


Lys Gly Phe Gly Ala Met Leu Arg Phe Gly Lys Lys Lys Glu Asp Lys 
                805                 810                 815     


Gly Gly Lys Ala Glu Gln Lys Gly Thr Leu Lys His Gly Gly Leu Arg 
            820                 825                 830         


Glu Glu Glu Leu Glu Lys Met Lys Glu Glu Arg Glu Arg Ile Gly Ala 
        835                 840                 845             


Lys His Gln Glu Leu Arg Glu Lys Gln Ala Arg Gly Leu Leu Asp Tyr 
    850                 855                 860                 


Ala Thr Gly Ala Ile Gly Ser Val Tyr Asp Met Asp Asp Asp Glu Met 
865                 870                 875                 880 


Asp Pro Asn Tyr Ala Arg Val Asn His Phe Arg Glu Pro Cys Thr Ser 
                885                 890                 895     


Ala Asn Val Phe Arg Ser Pro Ser Pro Pro Arg Ala Gly Pro Phe Gly 
            900                 905                 910         


Tyr Pro Arg Asp Gly His Pro Leu Ser Pro Glu Arg Asp His Leu Glu 
        915                 920                 925             


Gly Leu Tyr Ala Lys Val Asn Lys Pro Tyr His Pro Leu Val Pro Ala 
    930                 935                 940                 


Asp Ser Gly Arg Pro Thr Gly Gly Ser Thr Asp Arg Ile Gln Lys Leu 
945                 950                 955                 960 


Arg Lys Glu Tyr Tyr Gln Ala Arg Arg Glu Gly Phe Pro Leu Tyr Glu 
                965                 970                 975     


Asp Asp Glu Gly Arg Ala Arg Pro Ser Glu Tyr Asp Leu Leu Trp Val 
            980                 985                 990         


Pro Gly Arg Gly Pro Asp Gly Asn  Ala His Asn Leu Arg  Phe Glu Gly 
        995                 1000                 1005             


Met Glu  Arg Gln Tyr Ala Ser  Leu Pro Arg Gly Gly  Pro Ala Asp 
    1010                 1015                 1020             


Pro Val  Asp Tyr Leu Pro Ala  Ala Pro Arg Gly Leu  Tyr Lys Glu 
    1025                 1030                 1035             


Arg Glu  Leu Pro Tyr Tyr Pro  Gly Ala His Pro Met  His Pro Pro 
    1040                 1045                 1050             


Lys Gly  Ser Tyr Pro Arg Pro  Thr Glu Leu Arg Val  Ala Asp Leu 
    1055                 1060                 1065             


Arg Tyr  Pro Gln His Tyr Pro  Pro Pro Pro Ala Pro  Gln His Lys 
    1070                 1075                 1080             


Gly Pro  Phe Arg Gln Asp Val  Pro Pro Ser Pro Pro  Gln His Gln 
    1085                 1090                 1095             


Arg Met  Pro Ala Tyr Gln Glu  Thr Gly Arg Pro Gly  Pro Arg Gly 
    1100                 1105                 1110             


Gly Ser  Pro Asp Gln Tyr Pro  Tyr Arg Thr Gln Asp  Ser Arg Gln 
    1115                 1120                 1125             


Lys Asn  Pro Met Thr Ala Ala  Val 
    1130                 1135     


<210>  8885
<211>  3339
<212>  DNA
<213>  Homosapiens

<400>  8885
gcggccgccc ctccccgatt cccgccacct gccgcctggc caggtggaag gggcgctgcc     60

gcgagcctcc gggcctcagg gtgttccggg gagcggcgcc ccgggtctct gggcccaccc    120

gccccgggcg tcctccgaga gtgggggctg cgcccgcggg gtcagacacc tgttcggccc    180

ggcccggcgt ggtcgccggg ggccaggatg aaagtgaccg tgtgcttcgg caggacgggc    240

atcgtggtgc cctgcaagga gggccagctg cgcgtcggcg agctcaccca gcaggcgctg    300

cagcggtacc tgaagacccg ggagaagggt cctggttact gggtgaagat tcatcactta    360

gaatatacag atggaggaat cctggatcca gatgatgtct tggcagatgt tgttgaagat    420

aaagacaagc tgattgctgt gtttgaagaa caagaaccac tccacaagat tgagagcccc    480

agtggaaacc ctgcagatcg gcagagccca gatgcttttg agacagaagt ggccgcccaa    540

ctggccgcat ttaagccaat tggtggggag attgaagtaa ccccttctgc tctaaaacta    600

ggcactccac tgctggtgag gagaagcagt gacccagtgc caggcccacc tgctgatacc    660

cagccaagcg cttcacaccc tggtggccag agtctgaaac tggttgttcc agattccacg    720

cagaacttgg aagacagaga agttttgaat ggtgtacaga cagaactact aacttcgcca    780

agaactaagg acacattgag tgatatgaca agaacagtgg agatttctgg ggaaggaggc    840

ccattgggaa tacatgtagt gcccttcttt tcatctctga gtggaaggat tctaggactc    900

ttcatccgag gcattgaaga caacagcagg tccaagcggg agggactatt tcacgaaaat    960

gaatgtattg taaaaatcaa caatgtggat ctcgtagaca aaacctttgc tcaggctcaa   1020

gatgtcttcc gccaggcaat gaaatctcca agtgtgctcc tccacgtgct tcctccacaa   1080

aaccgtgaac agtatgaaaa gtcagtcatt ggctctctta acatttttgg taataatgat   1140

ggcgttttga aaaccaaagt gccgcctcct gtccatggaa aatcgggact aaagacagca   1200

aatctcacag gaaccgatag tcctgaaaca gatgcatcag cttccctgca acaaaacaag   1260

agtccccgag taccaaggct gggaggaaaa ccatcctctc cctcactctc gcctctcatg   1320

ggatttggca gcaataaaaa tgcaaagaaa attaagattg acctaaagaa aggccctgaa   1380

ggacttggtt tcactgtggt taccagagac tcttccatac atggtcccgg tcccattttt   1440

gtaaaaaaca ttttaccaaa gggagcagca ataaaagatg gccgcctaca atcaggggac   1500

agaattttgg aggtaaatgg gagagatgtc accggacgaa cccaggaaga gcttgtggcc   1560

atgctcagga gcaccaagca gggggagaca gcatcgctgg tcattgcccg ccaagaagga   1620

cattttctgc cccgagagtt gaaaggagaa cctgactgct gtgcactctc tctggagaca   1680

agcgagcagc tcacctttga gatccccctg aatgattcag gttctgctgg cctcggggtg   1740

agcttaaaag ggaacaaatc cagagaaact ggaacagact tggggatttt tatcaaatcc   1800

atcattcatg gaggcgctgc ttttaaggat ggtcgtctgc gaatgaatga ccagctgatt   1860

gcagttaatg gggaatctct tttgggaaag tccaaccacg aagctatgga aacacttagg   1920

cggtcaatgt ccatggaggg aaacatccga gggatgatcc agttggtgat tctgaggagg   1980

ccagagagac caatggagga tcctgcagag tgtggggcat tttccaagcc atgctttgag   2040

aactgtcaaa atgctgtaac cacctctagg cgaaatgata atagtatcct gcatccactt   2100

ggcacttgca gtccacaaga caaacagaaa ggtctattgc tgcccaatga cggatgggcc   2160

gagagtgaag ttccaccttc tccaacacca cattctgctc tgggattggg cctcgaagat   2220

tacagccaca gctctggggt ggattcagca gtatattttc cagatcagca catcaacttc   2280

agatctgtga caccggccag gcagcctgaa tcaattaatt tgaaagcctc gaagagcatg   2340

gaccttgtgc cagatgaaag caaggttcac tcattggctg gacaaaaatc ggaatctcca   2400

agcaaagatt ttggtccaac tctgggtttg aaaaagtcca gctccttgga gagtctgcag   2460

actgcagtgg ccgaggtcag gaagaatgac cttccctttc acaggccccg gccgcacatg   2520

gttcgaggcc gaggctgcaa tgagagcttt agagcagcca ttgacaaatc ctacgatgga   2580

cctgaagaaa tagaagctga cggtctgtct gataagagct ctcactctgg ccaaggagct   2640

ctgaattgtg agtctgcccc tcaggggaat tcggagctag aggacatgga aaataaagcc   2700

aggaaagtca aaaaaacgaa agagaaggag aagaaaaagg aaaagggcaa attgaaagtc   2760

aaggagaaaa agcgcaaaga ggagaatgaa gatccagaaa ggaaaataaa gaagaagggc   2820

ttcggcgcca tgctgagagt ggccgtccta cgggtggaag cactgaccgt atccagaagt   2880

tgcggaaaga gtattatcag gctcggaggg aaggtttccc tttatatgaa gacgacgaag   2940

gaagagcaag gccatctgag tatgacctac tctgggtcca ggggaggacc cgcagatcct   3000

gtagactatc tgccagcagc acctcggggg ctctacaagg aaagggagct tccctattat   3060

ccaggggctc atcctatgca ccctcccaaa gggagctatc cccgccccac agagctcagg   3120

gtggcagatc tccggtatcc tcagcactac ccacccccgc cagctcccca gcacaaagga   3180

ccctttcgac aagacgttcc gccttcccct ccccagcacc aaagaatgcc agcctatcag   3240

gaaacaggca gaccagggcc ccgtgggggc agcccagacc agtaccctta ccgaacccag   3300

gattcccggc agaagaaccc catgactgca gccgtatag                          3339


<210>  8886
<211>  1043
<212>  PRT
<213>  Homosapiens

<400>  8886

Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Gly Pro Gly Tyr Trp Val Lys Ile 
        35                  40                  45              


His His Leu Glu Tyr Thr Asp Gly Gly Ile Leu Asp Pro Asp Asp Val 
    50                  55                  60                  


Leu Ala Asp Val Val Glu Asp Lys Asp Lys Leu Ile Ala Val Phe Glu 
65                  70                  75                  80  


Glu Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro Ala 
                85                  90                  95      


Asp Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln Leu 
            100                 105                 110         


Ala Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser Ala 
        115                 120                 125             


Leu Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro Val 
    130                 135                 140                 


Pro Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly Gly 
145                 150                 155                 160 


Gln Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu Asp 
                165                 170                 175     


Arg Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro Arg 
            180                 185                 190         


Thr Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser Gly 
        195                 200                 205             


Glu Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser Leu 
    210                 215                 220                 


Ser Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn Ser 
225                 230                 235                 240 


Arg Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val Lys 
                245                 250                 255     


Ile Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln Asp 
            260                 265                 270         


Val Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val Leu 
        275                 280                 285             


Pro Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser Leu 
    290                 295                 300                 


Asn Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro Pro 
305                 310                 315                 320 


Pro Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly Thr 
                325                 330                 335     


Asp Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys Ser 
            340                 345                 350         


Pro Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu Ser 
        355                 360                 365             


Pro Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys Ile 
    370                 375                 380                 


Asp Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr Arg 
385                 390                 395                 400 


Asp Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile Leu 
                405                 410                 415     


Pro Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp Arg 
            420                 425                 430         


Ile Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu Glu 
        435                 440                 445             


Leu Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser Leu 
    450                 455                 460                 


Val Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Lys Gly 
465                 470                 475                 480 


Glu Pro Asp Cys Cys Ala Leu Ser Leu Glu Thr Ser Glu Gln Leu Thr 
                485                 490                 495     


Phe Glu Ile Pro Leu Asn Asp Ser Gly Ser Ala Gly Leu Gly Val Ser 
            500                 505                 510         


Leu Lys Gly Asn Lys Ser Arg Glu Thr Gly Thr Asp Leu Gly Ile Phe 
        515                 520                 525             


Ile Lys Ser Ile Ile His Gly Gly Ala Ala Phe Lys Asp Gly Arg Leu 
    530                 535                 540                 


Arg Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu Leu Gly 
545                 550                 555                 560 


Lys Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met Ser Met 
                565                 570                 575     


Glu Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg Arg Pro 
            580                 585                 590         


Glu Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser Lys Pro 
        595                 600                 605             


Cys Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg Asn Asp 
    610                 615                 620                 


Asn Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp Lys Gln 
625                 630                 635                 640 


Lys Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu Val Pro 
                645                 650                 655     


Pro Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu Asp Tyr 
            660                 665                 670         


Ser His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp Gln His 
        675                 680                 685             


Ile Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser Ile Asn 
    690                 695                 700                 


Leu Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser Lys Val 
705                 710                 715                 720 


His Ser Leu Ala Gly Gln Lys Ser Glu Ser Pro Ser Lys Asp Phe Gly 
                725                 730                 735     


Pro Thr Leu Gly Leu Lys Lys Ser Ser Ser Leu Glu Ser Leu Gln Thr 
            740                 745                 750         


Ala Val Ala Glu Val Arg Lys Asn Asp Leu Pro Phe His Arg Pro Arg 
        755                 760                 765             


Pro His Met Val Arg Gly Arg Gly Cys Asn Glu Ser Phe Arg Ala Ala 
    770                 775                 780                 


Ile Asp Lys Ser Tyr Asp Gly Pro Glu Glu Ile Glu Ala Asp Gly Leu 
785                 790                 795                 800 


Ser Asp Lys Ser Ser His Ser Gly Gln Gly Ala Leu Asn Cys Glu Ser 
                805                 810                 815     


Ala Pro Gln Gly Asn Ser Glu Leu Glu Asp Met Glu Asn Lys Ala Arg 
            820                 825                 830         


Lys Val Lys Lys Thr Lys Glu Lys Glu Lys Lys Lys Glu Lys Gly Lys 
        835                 840                 845             


Leu Lys Val Lys Glu Lys Lys Arg Lys Glu Glu Asn Glu Asp Pro Glu 
    850                 855                 860                 


Arg Lys Ile Lys Lys Lys Gly Phe Gly Ala Met Leu Arg Val Ala Val 
865                 870                 875                 880 


Leu Arg Val Glu Ala Leu Thr Val Ser Arg Ser Cys Gly Lys Ser Ile 
                885                 890                 895     


Ile Arg Leu Gly Gly Lys Val Ser Leu Tyr Met Lys Thr Thr Lys Glu 
            900                 905                 910         


Glu Gln Gly His Leu Ser Met Thr Tyr Ser Gly Ser Arg Gly Gly Pro 
        915                 920                 925             


Ala Asp Pro Val Asp Tyr Leu Pro Ala Ala Pro Arg Gly Leu Tyr Lys 
    930                 935                 940                 


Glu Arg Glu Leu Pro Tyr Tyr Pro Gly Ala His Pro Met His Pro Pro 
945                 950                 955                 960 


Lys Gly Ser Tyr Pro Arg Pro Thr Glu Leu Arg Val Ala Asp Leu Arg 
                965                 970                 975     


Tyr Pro Gln His Tyr Pro Pro Pro Pro Ala Pro Gln His Lys Gly Pro 
            980                 985                 990         


Phe Arg Gln Asp Val Pro Pro Ser  Pro Pro Gln His Gln  Arg Met Pro 
        995                 1000                 1005             


Ala Tyr  Gln Glu Thr Gly Arg  Pro Gly Pro Arg Gly  Gly Ser Pro 
    1010                 1015                 1020             


Asp Gln  Tyr Pro Tyr Arg Thr  Gln Asp Ser Arg Gln  Lys Asn Pro 
    1025                 1030                 1035             


Met Thr  Ala Ala Val 
    1040             


<210>  8887
<211>  3639
<212>  DNA
<213>  Homosapiens

<400>  8887
gcggccgccc ctccccgatt cccgccacct gccgcctggc caggtggaag gggcgctgcc     60

gcgagcctcc gggcctcagg gtgttccggg gagcggcgcc ccgggtctct gggcccaccc    120

gccccgggcg tcctccgaga gtgggggctg cgcccgcggg gtcagacacc tgttcggccc    180

ggcccggcgt ggtcgccggg ggccaggatg aaagtgaccg tgtgcttcgg caggacgggc    240

atcgtggtgc cctgcaagga gggccagctg cgcgtcggcg agctcaccca gcaggcgctg    300

cagcggtacc tgaagacccg ggagaagggt cctggttact gggtgaagat tcatcactta    360

gaatatacag atggaggaat cctggatcca gatgatgtct tggcagatgt tgttgaagat    420

aaagacaagc tgattgctgt gtttgaagaa caagaaccac tccacaagat tgagagcccc    480

agtggaaacc ctgcagatcg gcagagccca gatgcttttg agacagaagt ggccgcccaa    540

ctggccgcat ttaagccaat tggtggggag attgaagtaa ccccttctgc tctaaaacta    600

ggcactccac tgctggtgag gagaagcagt gacccagtgc caggcccacc tgctgatacc    660

cagccaagcg cttcacaccc tggtggccag agtctgaaac tggttgttcc agattccacg    720

cagaacttgg aagacagaga agttttgaat ggtgtacaga cagaactact aacttcgcca    780

agaactaagg acacattgag tgatatgaca agaacagtgg agatttctgg ggaaggaggc    840

ccattgggaa tacatgtagt gcccttcttt tcatctctga gtggaaggat tctaggactc    900

ttcatccgag gcattgaaga caacagcagg tccaagcggg agggactatt tcacgaaaat    960

gaatgtattg taaaaatcaa caatgtggat ctcgtagaca aaacctttgc tcaggctcaa   1020

gatgtcttcc gccaggcaat gaaatctcca agtgtgctcc tccacgtgct tcctccacaa   1080

aaccgtgaac agtatgaaaa gtcagtcatt ggctctctta acatttttgg taataatgat   1140

ggcgttttga aaaccaaagt gccgcctcct gtccatggaa aatcgggact aaagacagca   1200

aatctcacag gaaccgatag tcctgaaaca gatgcatcag cttccctgca acaaaacaag   1260

agtccccgag taccaaggct gggaggaaaa ccatcctctc cctcactctc gcctctcatg   1320

ggatttggca gcaataaaaa tgcaaagaaa attaagattg acctaaagaa aggccctgaa   1380

ggacttggtt tcactgtggt taccagagac tcttccatac atggtcccgg tcccattttt   1440

gtaaaaaaca ttttaccaaa gggagcagca ataaaagatg gccgcctaca atcaggggac   1500

agaattttgg aggtaaatgg gagagatgtc accggacgaa cccaggaaga gcttgtggcc   1560

atgctcagga gcaccaagca gggggagaca gcatcgctgg tcattgcccg ccaagaagga   1620

cattttctgc cccgagagtt ggatggtcgt ctgcgaatga atgaccagct gattgcagtt   1680

aatggggaat ctcttttggg aaagtccaac cacgaagcta tggaaacact taggcggtca   1740

atgtccatgg agggaaacat ccgagggatg atccagttgg tgattctgag gaggccagag   1800

agaccaatgg aggatcctgc agagtgtggg gcattttcca agccatgctt tgagaactgt   1860

caaaatgctg taaccacctc taggcgaaat gataatagta tcctgcatcc acttggcact   1920

tgcagtccac aagacaaaca gaaaggtcta ttgctgccca atgacggatg ggccgagagt   1980

gaagttccac cttctccaac accacattct gctctgggat tgggcctcga agattacagc   2040

cacagctctg gggtggattc agcagtatat tttccagatc agcacatcaa cttcagatct   2100

gtgacaccgg ccaggcagcc tgaatcaatt aatttgaaag cctcgaagag catggacctt   2160

gtgccagatg aaagcaaggt tcactcattg gctggacaaa aatcggaatc tccaagcaaa   2220

gattttggtc caactctggg tttgaaaaag tccagctcct tggagagtct gcagactgca   2280

gtggccgagg tcaggaagaa tgaccttccc tttcacaggc cccggccgca catggttcga   2340

ggccgaggct gcaatgagag ctttagagca gccattgaca aatcctacga tggacctgaa   2400

gaaatagaag ctgacggtct gtctgataag agctctcact ctggccaagg agctctgaat   2460

tgtgagtctg cccctcaggg gaattcggag ctagaggaca tggaaaataa agccaggaaa   2520

gtcaaaaaaa cgaaagagaa ggagaagaaa aaggaaaagg gcaaattgaa agtcaaggag   2580

aaaaagcgca aagaggagaa tgaagatcca gaaaggaaaa taaagaagaa gggcttcggc   2640

gccatgctga gatttggaaa gaagaaagag gataagggtg gaaaggctga gcagaaaggt   2700

actctgaaac atggtggcct gagagaagaa gagctggaga aaatgaaaga agagcgtgaa   2760

aggattggag caaaacatca ggagctaagg gaaaagcagg caagaggtct tcttgattat   2820

gctactggtg caattggatc agtgtatgat atggatgatg atgaaatgga ccccaattat   2880

gccagagtga accactttcg ggaaccatgc acatcagcaa atgtctttag atctccatct   2940

ccccctcgag ctggaccatt tggttaccct cgggatggcc atccactgtc tccagaaaga   3000

gaccacttag agggtctcta tgccaaggtc aacaagccat accatccact ggttccagct   3060

gacagtggcc gtcctacggg tggaagcact gaccgtatcc agaagttgcg gaaagagtat   3120

tatcaggctc ggagggaagg tttcccttta tatgaagacg acgaaggaag agcaaggcca   3180

tctgagtatg acctactctg ggtgcctgga aggggtccag atgggaatgc acacaacctc   3240

cgctttgaag ggatggagag gcagtacgca tccttaccca ggggaggacc cgcagatcct   3300

gtagactatc tgccagcagc acctcggggg ctctacaagg aaagggagct tccctattat   3360

ccaggggctc atcctatgca ccctcccaaa gggagctatc cccgccccac agagctcagg   3420

gtggcagatc tccggtatcc tcagcactac ccacccccgc cagctcccca gcacaaagga   3480

ccctttcgac aagacgttcc gccttcccct ccccagcacc aaagaatgcc agcctatcag   3540

gaaacaggca gaccagggcc ccgtgggggc agcccagacc agtaccctta ccgaacccag   3600

gattcccggc agaagaaccc catgactgca gccgtatag                          3639


<210>  8888
<211>  1143
<212>  PRT
<213>  Homosapiens

<400>  8888

Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Gly Pro Gly Tyr Trp Val Lys Ile 
        35                  40                  45              


His His Leu Glu Tyr Thr Asp Gly Gly Ile Leu Asp Pro Asp Asp Val 
    50                  55                  60                  


Leu Ala Asp Val Val Glu Asp Lys Asp Lys Leu Ile Ala Val Phe Glu 
65                  70                  75                  80  


Glu Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro Ala 
                85                  90                  95      


Asp Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln Leu 
            100                 105                 110         


Ala Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser Ala 
        115                 120                 125             


Leu Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro Val 
    130                 135                 140                 


Pro Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly Gly 
145                 150                 155                 160 


Gln Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu Asp 
                165                 170                 175     


Arg Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro Arg 
            180                 185                 190         


Thr Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser Gly 
        195                 200                 205             


Glu Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser Leu 
    210                 215                 220                 


Ser Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn Ser 
225                 230                 235                 240 


Arg Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val Lys 
                245                 250                 255     


Ile Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln Asp 
            260                 265                 270         


Val Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val Leu 
        275                 280                 285             


Pro Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser Leu 
    290                 295                 300                 


Asn Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro Pro 
305                 310                 315                 320 


Pro Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly Thr 
                325                 330                 335     


Asp Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys Ser 
            340                 345                 350         


Pro Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu Ser 
        355                 360                 365             


Pro Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys Ile 
    370                 375                 380                 


Asp Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr Arg 
385                 390                 395                 400 


Asp Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile Leu 
                405                 410                 415     


Pro Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp Arg 
            420                 425                 430         


Ile Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu Glu 
        435                 440                 445             


Leu Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser Leu 
    450                 455                 460                 


Val Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Asp Gly 
465                 470                 475                 480 


Arg Leu Arg Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu 
                485                 490                 495     


Leu Gly Lys Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met 
            500                 505                 510         


Ser Met Glu Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg 
        515                 520                 525             


Arg Pro Glu Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser 
    530                 535                 540                 


Lys Pro Cys Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg 
545                 550                 555                 560 


Asn Asp Asn Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp 
                565                 570                 575     


Lys Gln Lys Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu 
            580                 585                 590         


Val Pro Pro Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu 
        595                 600                 605             


Asp Tyr Ser His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp 
    610                 615                 620                 


Gln His Ile Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser 
625                 630                 635                 640 


Ile Asn Leu Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser 
                645                 650                 655     


Lys Val His Ser Leu Ala Gly Gln Lys Ser Glu Ser Pro Ser Lys Asp 
            660                 665                 670         


Phe Gly Pro Thr Leu Gly Leu Lys Lys Ser Ser Ser Leu Glu Ser Leu 
        675                 680                 685             


Gln Thr Ala Val Ala Glu Val Arg Lys Asn Asp Leu Pro Phe His Arg 
    690                 695                 700                 


Pro Arg Pro His Met Val Arg Gly Arg Gly Cys Asn Glu Ser Phe Arg 
705                 710                 715                 720 


Ala Ala Ile Asp Lys Ser Tyr Asp Gly Pro Glu Glu Ile Glu Ala Asp 
                725                 730                 735     


Gly Leu Ser Asp Lys Ser Ser His Ser Gly Gln Gly Ala Leu Asn Cys 
            740                 745                 750         


Glu Ser Ala Pro Gln Gly Asn Ser Glu Leu Glu Asp Met Glu Asn Lys 
        755                 760                 765             


Ala Arg Lys Val Lys Lys Thr Lys Glu Lys Glu Lys Lys Lys Glu Lys 
    770                 775                 780                 


Gly Lys Leu Lys Val Lys Glu Lys Lys Arg Lys Glu Glu Asn Glu Asp 
785                 790                 795                 800 


Pro Glu Arg Lys Ile Lys Lys Lys Gly Phe Gly Ala Met Leu Arg Phe 
                805                 810                 815     


Gly Lys Lys Lys Glu Asp Lys Gly Gly Lys Ala Glu Gln Lys Gly Thr 
            820                 825                 830         


Leu Lys His Gly Gly Leu Arg Glu Glu Glu Leu Glu Lys Met Lys Glu 
        835                 840                 845             


Glu Arg Glu Arg Ile Gly Ala Lys His Gln Glu Leu Arg Glu Lys Gln 
    850                 855                 860                 


Ala Arg Gly Leu Leu Asp Tyr Ala Thr Gly Ala Ile Gly Ser Val Tyr 
865                 870                 875                 880 


Asp Met Asp Asp Asp Glu Met Asp Pro Asn Tyr Ala Arg Val Asn His 
                885                 890                 895     


Phe Arg Glu Pro Cys Thr Ser Ala Asn Val Phe Arg Ser Pro Ser Pro 
            900                 905                 910         


Pro Arg Ala Gly Pro Phe Gly Tyr Pro Arg Asp Gly His Pro Leu Ser 
        915                 920                 925             


Pro Glu Arg Asp His Leu Glu Gly Leu Tyr Ala Lys Val Asn Lys Pro 
    930                 935                 940                 


Tyr His Pro Leu Val Pro Ala Asp Ser Gly Arg Pro Thr Gly Gly Ser 
945                 950                 955                 960 


Thr Asp Arg Ile Gln Lys Leu Arg Lys Glu Tyr Tyr Gln Ala Arg Arg 
                965                 970                 975     


Glu Gly Phe Pro Leu Tyr Glu Asp Asp Glu Gly Arg Ala Arg Pro Ser 
            980                 985                 990         


Glu Tyr Asp Leu Leu Trp Val Pro  Gly Arg Gly Pro Asp  Gly Asn Ala 
        995                 1000                 1005             


His Asn  Leu Arg Phe Glu Gly  Met Glu Arg Gln Tyr  Ala Ser Leu 
    1010                 1015                 1020             


Pro Arg  Gly Gly Pro Ala Asp  Pro Val Asp Tyr Leu  Pro Ala Ala 
    1025                 1030                 1035             


Pro Arg  Gly Leu Tyr Lys Glu  Arg Glu Leu Pro Tyr  Tyr Pro Gly 
    1040                 1045                 1050             


Ala His  Pro Met His Pro Pro  Lys Gly Ser Tyr Pro  Arg Pro Thr 
    1055                 1060                 1065             


Glu Leu  Arg Val Ala Asp Leu  Arg Tyr Pro Gln His  Tyr Pro Pro 
    1070                 1075                 1080             


Pro Pro  Ala Pro Gln His Lys  Gly Pro Phe Arg Gln  Asp Val Pro 
    1085                 1090                 1095             


Pro Ser  Pro Pro Gln His Gln  Arg Met Pro Ala Tyr  Gln Glu Thr 
    1100                 1105                 1110             


Gly Arg  Pro Gly Pro Arg Gly  Gly Ser Pro Asp Gln  Tyr Pro Tyr 
    1115                 1120                 1125             


Arg Thr  Gln Asp Ser Arg Gln  Lys Asn Pro Met Thr  Ala Ala Val 
    1130                 1135                 1140             


<210>  8889
<211>  3312
<212>  DNA
<213>  Homosapiens

<400>  8889
atgaaagtga ccgtgtgctt cggcaggacg ggcatcgtgg tgccctgcaa ggagggccag     60

ctgcgcgtcg gcgagctcac ccagcaggcg ctgcagcggt acctgaagac ccgggagaag    120

gagctgattg ctgtgtttga agaacaagaa ccactccaca agattgagag ccccagtgga    180

aaccctgcag atcggcagag cccagatgct tttgagacag aagtggccgc ccaactggcc    240

gcatttaagc caattggtgg ggagattgaa gtaacccctt ctgctctaaa actaggcact    300

ccactgctgg tgaggagaag cagtgaccca gtgccaggcc cacctgctga tacccagcca    360

agcgcttcac accctggtgg ccagagtctg aaactggttg ttccagattc cacgcagaac    420

ttggaagaca gagaagtttt gaatggtgta cagacagaac tactaacttc gccaagaact    480

aaggacacat tgagtgatat gacaagaaca gtggagattt ctggggaagg aggcccattg    540

ggaatacatg tagtgccctt cttttcatct ctgagtggaa ggattctagg actcttcatc    600

cgaggcattg aagacaacag caggtccaag cgggagggac tatttcacga aaatgaatgt    660

attgtaaaaa tcaacaatgt ggatctcgta gacaaaacct ttgctcaggc tcaagatgtc    720

ttccgccagg caatgaaatc tccaagtgtg ctcctccacg tgcttcctcc acaaaaccgt    780

gaacagtatg aaaagtcagt cattggctct cttaacattt ttggtaataa tgatggcgtt    840

ttgaaaacca aagtgccgcc tcctgtccat ggaaaatcgg gactaaagac agcaaatctc    900

acaggaaccg atagtcctga aacagatgca tcagcttccc tgcaacaaaa caagagtccc    960

cgagtaccaa ggctgggagg aaaaccatcc tctccctcac tctcgcctct catgggattt   1020

ggcagcaata aaaatgcaaa gaaaattaag attgacctaa agaaaggccc tgaaggactt   1080

ggtttcactg tggttaccag agactcttcc atacatggtc ccggtcccat ttttgtaaaa   1140

aacattttac caaagggagc agcaataaaa gatggccgcc tacaatcagg ggacagaatt   1200

ttggaggtaa atgggagaga tgtcaccgga cgaacccagg aagagcttgt ggccatgctc   1260

aggagcacca agcaggggga gacagcatcg ctggtcattg cccgccaaga aggacatttt   1320

ctgccccgag agttgaaagg agaacctgac tgctgtgcac tctctctgga gacaagcgag   1380

cagctcacct ttgagatccc cctgaatgat tcaggttctg ctggcctcgg ggtgagctta   1440

aaagggaaca aatccagaga aactggaaca gacttgggga tttttatcaa atccatcatt   1500

catggaggcg ctgcttttaa ggatggtcgt ctgcgaatga atgaccagct gattgcagtt   1560

aatggggaat ctcttttggg aaagtccaac cacgaagcta tggaaacact taggcggtca   1620

atgtccatgg agggaaacat ccgagggatg atccagttgg tgattctgag gaggccagag   1680

agaccaatgg aggatcctgc agagtgtggg gcattttcca agccatgctt tgagaactgt   1740

caaaatgctg taaccacctc taggcgaaat gataatagta tcctgcatcc acttggcact   1800

tgcagtccac aagacaaaca gaaaggtcta ttgctgccca atgacggatg ggccgagagt   1860

gaagttccac cttctccaac accacattct gctctgggat tgggcctcga agattacagc   1920

cacagctctg gggtggattc agcagtatat tttccagatc agcacatcaa cttcagatct   1980

gtgacaccgg ccaggcagcc tgaatcaatt aatttgaaag cctcgaagag catggacctt   2040

gtgccagatg aaagcaaggt tcactcattg gctggacaaa aatcggacgg tctgtctgat   2100

aagagctctc actctggcca aggagctctg aattgtgagt ctgcccctca ggggaattcg   2160

gagctagagg acatggaaaa taaagccagg aaagtcaaaa aaacgaaaga gaaggagaag   2220

aaaaaggaaa agggcaaatt gaaagtcaag gagaaaaagc gcaaagagga gaatgaagat   2280

ccagaaagga aaataaagaa gaagggcttc ggcgccatgc tgagatttgg aaagaagaaa   2340

gaggataagg gtggaaaggc tgagcagaaa ggtactctga aacatggtgg cctgagagaa   2400

gaagagctgg agaaaatgaa agaagagcgt gaaaggattg gagcaaaaca tcaggagcta   2460

agggaaaagc aggcaagagg tcttcttgat tatgctactg gtgcaattgg atcagtgtat   2520

gatatggatg atgatgaaat ggaccccaat tatgccagag tgaaccactt tcgggaacca   2580

tgcacatcag caaatgtctt tagatctcca tctccccctc gagctggacc atttggttac   2640

cctcgggatg gccatccact gtctccagaa agagaccact tagagggtct ctatgccaag   2700

gtcaacaagc cataccatcc actggttcca gctgacagtg gccgtcctac gggtggaagc   2760

actgaccgta tccagaagtt gcggaaagag tattatcagg ctcggaggga aggtttccct   2820

ttatatgaag acgacgaagg aagagcaagg ccatctgagt atgacctact ctgggtgcct   2880

ggaaggggtc cagatgggaa tgcacacaac ctccgctttg aagggatgga gaggcagtac   2940

gcatccttac ccaggggagg acccgcagat cctgtagact atctgccagc agcacctcgg   3000

gggctctaca aggaaaggga gcttccctat tatccagggg ctcatcctat gcaccctccc   3060

aaagggagct atccccgccc cacagagctc agggtggcag atctccggta tcctcagcac   3120

tacccacccc cgccagctcc ccagcacaaa ggaccctttc gacaagacgt tccgccttcc   3180

cctccccagc accaaagaat gccagcctat caggaaacag gcagaccagg gccccgtggg   3240

ggcagcccag accagtaccc ttaccgaacc caggattccc ggcagaagaa ccccatgact   3300

gcagccgtat ag                                                       3312


<210>  8890
<211>  1103
<212>  PRT
<213>  Homosapiens

<400>  8890

Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Glu Leu Ile Ala Val Phe Glu Glu 
        35                  40                  45              


Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro Ala Asp 
    50                  55                  60                  


Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln Leu Ala 
65                  70                  75                  80  


Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser Ala Leu 
                85                  90                  95      


Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro Val Pro 
            100                 105                 110         


Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly Gly Gln 
        115                 120                 125             


Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu Asp Arg 
    130                 135                 140                 


Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro Arg Thr 
145                 150                 155                 160 


Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser Gly Glu 
                165                 170                 175     


Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser Leu Ser 
            180                 185                 190         


Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn Ser Arg 
        195                 200                 205             


Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val Lys Ile 
    210                 215                 220                 


Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln Asp Val 
225                 230                 235                 240 


Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val Leu Pro 
                245                 250                 255     


Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser Leu Asn 
            260                 265                 270         


Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro Pro Pro 
        275                 280                 285             


Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly Thr Asp 
    290                 295                 300                 


Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys Ser Pro 
305                 310                 315                 320 


Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu Ser Pro 
                325                 330                 335     


Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys Ile Asp 
            340                 345                 350         


Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr Arg Asp 
        355                 360                 365             


Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile Leu Pro 
    370                 375                 380                 


Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp Arg Ile 
385                 390                 395                 400 


Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu Glu Leu 
                405                 410                 415     


Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser Leu Val 
            420                 425                 430         


Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Lys Gly Glu 
        435                 440                 445             


Pro Asp Cys Cys Ala Leu Ser Leu Glu Thr Ser Glu Gln Leu Thr Phe 
    450                 455                 460                 


Glu Ile Pro Leu Asn Asp Ser Gly Ser Ala Gly Leu Gly Val Ser Leu 
465                 470                 475                 480 


Lys Gly Asn Lys Ser Arg Glu Thr Gly Thr Asp Leu Gly Ile Phe Ile 
                485                 490                 495     


Lys Ser Ile Ile His Gly Gly Ala Ala Phe Lys Asp Gly Arg Leu Arg 
            500                 505                 510         


Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu Leu Gly Lys 
        515                 520                 525             


Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met Ser Met Glu 
    530                 535                 540                 


Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg Arg Pro Glu 
545                 550                 555                 560 


Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser Lys Pro Cys 
                565                 570                 575     


Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg Asn Asp Asn 
            580                 585                 590         


Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp Lys Gln Lys 
        595                 600                 605             


Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu Val Pro Pro 
    610                 615                 620                 


Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu Asp Tyr Ser 
625                 630                 635                 640 


His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp Gln His Ile 
                645                 650                 655     


Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser Ile Asn Leu 
            660                 665                 670         


Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser Lys Val His 
        675                 680                 685             


Ser Leu Ala Gly Gln Lys Ser Asp Gly Leu Ser Asp Lys Ser Ser His 
    690                 695                 700                 


Ser Gly Gln Gly Ala Leu Asn Cys Glu Ser Ala Pro Gln Gly Asn Ser 
705                 710                 715                 720 


Glu Leu Glu Asp Met Glu Asn Lys Ala Arg Lys Val Lys Lys Thr Lys 
                725                 730                 735     


Glu Lys Glu Lys Lys Lys Glu Lys Gly Lys Leu Lys Val Lys Glu Lys 
            740                 745                 750         


Lys Arg Lys Glu Glu Asn Glu Asp Pro Glu Arg Lys Ile Lys Lys Lys 
        755                 760                 765             


Gly Phe Gly Ala Met Leu Arg Phe Gly Lys Lys Lys Glu Asp Lys Gly 
    770                 775                 780                 


Gly Lys Ala Glu Gln Lys Gly Thr Leu Lys His Gly Gly Leu Arg Glu 
785                 790                 795                 800 


Glu Glu Leu Glu Lys Met Lys Glu Glu Arg Glu Arg Ile Gly Ala Lys 
                805                 810                 815     


His Gln Glu Leu Arg Glu Lys Gln Ala Arg Gly Leu Leu Asp Tyr Ala 
            820                 825                 830         


Thr Gly Ala Ile Gly Ser Val Tyr Asp Met Asp Asp Asp Glu Met Asp 
        835                 840                 845             


Pro Asn Tyr Ala Arg Val Asn His Phe Arg Glu Pro Cys Thr Ser Ala 
    850                 855                 860                 


Asn Val Phe Arg Ser Pro Ser Pro Pro Arg Ala Gly Pro Phe Gly Tyr 
865                 870                 875                 880 


Pro Arg Asp Gly His Pro Leu Ser Pro Glu Arg Asp His Leu Glu Gly 
                885                 890                 895     


Leu Tyr Ala Lys Val Asn Lys Pro Tyr His Pro Leu Val Pro Ala Asp 
            900                 905                 910         


Ser Gly Arg Pro Thr Gly Gly Ser Thr Asp Arg Ile Gln Lys Leu Arg 
        915                 920                 925             


Lys Glu Tyr Tyr Gln Ala Arg Arg Glu Gly Phe Pro Leu Tyr Glu Asp 
    930                 935                 940                 


Asp Glu Gly Arg Ala Arg Pro Ser Glu Tyr Asp Leu Leu Trp Val Pro 
945                 950                 955                 960 


Gly Arg Gly Pro Asp Gly Asn Ala His Asn Leu Arg Phe Glu Gly Met 
                965                 970                 975     


Glu Arg Gln Tyr Ala Ser Leu Pro Arg Gly Gly Pro Ala Asp Pro Val 
            980                 985                 990         


Asp Tyr Leu Pro Ala Ala Pro Arg  Gly Leu Tyr Lys Glu  Arg Glu Leu 
        995                 1000                 1005             


Pro Tyr  Tyr Pro Gly Ala His  Pro Met His Pro Pro  Lys Gly Ser 
    1010                 1015                 1020             


Tyr Pro  Arg Pro Thr Glu Leu  Arg Val Ala Asp Leu  Arg Tyr Pro 
    1025                 1030                 1035             


Gln His  Tyr Pro Pro Pro Pro  Ala Pro Gln His Lys  Gly Pro Phe 
    1040                 1045                 1050             


Arg Gln  Asp Val Pro Pro Ser  Pro Pro Gln His Gln  Arg Met Pro 
    1055                 1060                 1065             


Ala Tyr  Gln Glu Thr Gly Arg  Pro Gly Pro Arg Gly  Gly Ser Pro 
    1070                 1075                 1080             


Asp Gln  Tyr Pro Tyr Arg Thr  Gln Asp Ser Arg Gln  Lys Asn Pro 
    1085                 1090                 1095             


Met Thr  Ala Ala Val 
    1100             


<210>  8891
<211>  261
<212>  DNA
<213>  Homosapiens

<400>  8891
tccccaaaac gccacatgtc atcaccatac ttttctctgt tgaatattgt tttcctttct     60

tctgccttag gatggtcgtc tgcgaatgaa tgaccagctg attgcagtta atggggaatc    120

tcttttggga aagtccaacc acgaagctat ggaaacactt aggcggtcaa tgtccatgga    180

gggaaacatc cgagggatga tccagttggt gattctgagg aggccagaga gaccaatgga    240

ggatcctgca gagtgtgggg c                                              261


<210>  8892
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  8892

Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu Leu Gly Lys 
1               5                   10                  15      


Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met Ser Met Glu 
            20                  25                  30          


Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg Arg Pro Glu 
        35                  40                  45              


Arg Pro Met Glu Asp Pro Ala Glu Cys 
    50                  55          


<210>  8893
<211>  3796
<212>  DNA
<213>  Homosapiens

<400>  8893
gggcttggct tggagggggc aagggaggga aagagagaag ggggaaacac aaaaaacttc     60

tttctttctc cctccgttta tcttcagccc gacattgtca cctcctcttt gaggggttag    120

aagaagctga gatctcccga cagagctgga aatgcattgc actttgacta tggaaacaga    180

ggctattgat ggctatataa cgtgtgacaa tgagctttca cccgaaaggg agcactccaa    240

tatggcaatt gacctcacct caagcacacc caatggacag catgcctcac caagtcacat    300

gacaagcaca aattcagtaa agctagaaat gcagagtgat gaagagtgtg acaggaaacc    360

cctgagccgt gaagatgaga tcaggggcca tgatgagggt agcagcctag aagaacccct    420

aattgagagc agcgaggtgg ctgacaacag gaaagtccag gagcttcaag gcgagggagg    480

aatccggctt ccgaatggta aactgaaatg tgacgtctgt ggcatggttt gcattgggcc    540

caatgtgctt atggtacata aaaggagtca cactggtgaa cgccccttcc actgtaacca    600

gtgtggagct tcttttactc agaagggcaa ccttctgaga cacataaagt tacactctgg    660

agagaagccg ttcaaatgtc ctttctgtag ctacgcctgt agaagaaggg acgccctcac    720

aggacacctc aggacccatt ctgtgggtaa acctcacaag tgcaactact gtggacgaag    780

ctacaagcag cgcagttcac tggaggagca caaggaacgc tgccacaact atctccagaa    840

tgtcagcatg gaggctgctg ggcaggtcat gagtcaccat gtacctccta tggaagattg    900

taaggaacaa gagcctatta tggacaacaa tatttctctg gtgccttttg agagacctgc    960

tgtcatagag aagctcacgg ggaatatggg aaaacgtaaa agctccactc cacaaaagtt   1020

tgtgggggaa aagctcatgc gattcagcta cccagatatt cactttgata tgaacttaac   1080

atatgagaag gaggctgagc tgatgcagtc tcatatgatg gaccaagcca tcaacaatgc   1140

aatcacctac cttggagctg aggcccttca ccctctgatg cagcacccgc caagcacaat   1200

cgctgaagtg gccccagtta taagctcagc ttattctcag gtctatcatc caaataggat   1260

agaaagaccc attagcaggg aaactgctga tagtcatgaa aacaacatgg atggccccat   1320

ctctctcatc agaccaaaga gtcgacccca ggaaagagag gcctctccca gcaatagctg   1380

cctggattcc actgactcag aaagcagcca tgatgaccac cagtcctacc aaggacaccc   1440

tgccttaaat cccaagagga aacaaagccc agcttacatg aaggaggatg tcaaagcttt   1500

ggatactacc aaggctccta agggctctct gaaggacatc tacaaggtct tcaatggaga   1560

aggagaacag attagggcct tcaagtgtga gcactgccga gtccttttcc tagaccatgt   1620

catgtacacc attcacatgg gttgccatgg ctaccgggac ccactggaat gcaacatctg   1680

tggctacaga agccaggacc gttatgagtt ttcatcacac attgttcgag gggagcacac   1740

attccactag gccttttcat tccaaagggg acccctatga agtaaagaac tgcacatgaa   1800

gaaatactgc acttacaatc ccacctttcc tcaaatgttg acataccttt tatttttttt   1860

aatattatta ctgttgataa ttcttatttt gtggaggcag tgtcatttgc tctgcctaat   1920

tacgataagg aagaaacaga agagagaagg ggcgggaata ttgtttcttt atcacctggc   1980

ttgtttattt tgtgggaatt taagagcagt ccatttctac caaggcatat catgctttga   2040

aaaatcactt gattcataaa gattcaccta agagattctg atttgccact gatattcaga   2100

attatgatgg aagacaggaa agttcagagt tttctgggta ggactttggt ggtttaaaaa   2160

tggtataagt aactttattc ttgaaagaag aatgtgtttc aaactgtaaa ccaatttttt   2220

gttcttcaga gatcatggaa cacaaacaca ttgttatttt cagtgataac tcctaagagg   2280

agctgagttg ttgtgggttc tatgtttact tcccctatgg aatttataat tcagtatgtt   2340

ttacactgta ccatatagca aaacttttaa actacaggta gttaagggcc acctacaata   2400

catctgaggt cctgtgatct tatttttcta aacgtaagca ctgtttttcc atagttttga   2460

tgactggcat tttatagaca ccctggcagc cttactttta acacctttaa ggaatagtat   2520

ttttatgtag ttttcagaat aacatatggt ctaagagtgg ataaaaggca gtcaataatt   2580

tctgggaggg acttctactt tcataaattt gtttgagagg ttttctttta aagttgtaat   2640

gtgatggcag catagtatat gtatttgttt ctaaaagtat gcttacgatt gtcactttat   2700

cagcatttaa tcagtgttaa ccagtcagca gaaaaatata attatgctaa cagtaggggg   2760

agaaaaccca cttagaaatc ccttttctgg tatttctctt ttcactagtt tttttcaaga   2820

tgtgacctcc cggtgttctg tccatagttc attcatcctt tactcttcga gtagaaggtc   2880

ttaaaagtct tcctgtcggc tgtttctttc aaaatctcct cagagcaatt gctaatttgg   2940

cctgaatctg gtaacttgaa ccctgtaagg ttacagaact agggctattt attttagcat   3000

ttcttcagta gtatttacta ctcttgttgc aaagaaaagg gaatgggact tctttgtaac   3060

ctgtaccttg gacaacagat aaaagaaaca aaaaaataag aaagtttact tttacccttc   3120

ttggagtcta gaatgtgaca gaacccccaa aggaaagtcc tgcacatttt tctgtttcca   3180

aaacatttaa ttgtgtaagt ccttgtcaga aatgaatctc aatcccttag tatagaattc   3240

cccttacatg gtataggttg ccatatttca tgtgcagatt ttaatttcat ttatgtgggc   3300

gctctgtttt ttctttgcag tccagccaca ttagagggga ggaaccgagt gatattgatt   3360

caagtcattt tagggggaca tacttggaag gcagaacttg ctgcttctgt ttggggagga   3420

cagacctgac tgtgactgga ttatctgata accatttgtg aatactgaaa ttctgttagg   3480

cagtaactga taactgctct aaaggatcat taaataggat gctgaaatta tgtatcttaa   3540

tacagtgtgg tatgagaatt accaagtcaa gagaattgtg gacataagca agtttggccc   3600

caatactgct cttaactcat tttccagctt actatttgct atttaaatgg taggcaccag   3660

ctaagcactt ctaagcacta acacagctag aactaggcaa aaatggttag aactcagctc   3720

tcttctacta gtccctgtca taattatttt tgggaaaatg tccaaactgc cccctttaaa   3780

tctaagggaa tgcacc                                                   3796


<210>  8894
<211>  532
<212>  PRT
<213>  Homosapiens

<400>  8894

Met His Cys Thr Leu Thr Met Glu Thr Glu Ala Ile Asp Gly Tyr Ile 
1               5                   10                  15      


Thr Cys Asp Asn Glu Leu Ser Pro Glu Arg Glu His Ser Asn Met Ala 
            20                  25                  30          


Ile Asp Leu Thr Ser Ser Thr Pro Asn Gly Gln His Ala Ser Pro Ser 
        35                  40                  45              


His Met Thr Ser Thr Asn Ser Val Lys Leu Glu Met Gln Ser Asp Glu 
    50                  55                  60                  


Glu Cys Asp Arg Lys Pro Leu Ser Arg Glu Asp Glu Ile Arg Gly His 
65                  70                  75                  80  


Asp Glu Gly Ser Ser Leu Glu Glu Pro Leu Ile Glu Ser Ser Glu Val 
                85                  90                  95      


Ala Asp Asn Arg Lys Val Gln Glu Leu Gln Gly Glu Gly Gly Ile Arg 
            100                 105                 110         


Leu Pro Asn Gly Lys Leu Lys Cys Asp Val Cys Gly Met Val Cys Ile 
        115                 120                 125             


Gly Pro Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg 
    130                 135                 140                 


Pro Phe His Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
145                 150                 155                 160 


Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys 
                165                 170                 175     


Pro Phe Cys Ser Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His 
            180                 185                 190         


Leu Arg Thr His Ser Val Gly Lys Pro His Lys Cys Asn Tyr Cys Gly 
        195                 200                 205             


Arg Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys 
    210                 215                 220                 


His Asn Tyr Leu Gln Asn Val Ser Met Glu Ala Ala Gly Gln Val Met 
225                 230                 235                 240 


Ser His His Val Pro Pro Met Glu Asp Cys Lys Glu Gln Glu Pro Ile 
                245                 250                 255     


Met Asp Asn Asn Ile Ser Leu Val Pro Phe Glu Arg Pro Ala Val Ile 
            260                 265                 270         


Glu Lys Leu Thr Gly Asn Met Gly Lys Arg Lys Ser Ser Thr Pro Gln 
        275                 280                 285             


Lys Phe Val Gly Glu Lys Leu Met Arg Phe Ser Tyr Pro Asp Ile His 
    290                 295                 300                 


Phe Asp Met Asn Leu Thr Tyr Glu Lys Glu Ala Glu Leu Met Gln Ser 
305                 310                 315                 320 


His Met Met Asp Gln Ala Ile Asn Asn Ala Ile Thr Tyr Leu Gly Ala 
                325                 330                 335     


Glu Ala Leu His Pro Leu Met Gln His Pro Pro Ser Thr Ile Ala Glu 
            340                 345                 350         


Val Ala Pro Val Ile Ser Ser Ala Tyr Ser Gln Val Tyr His Pro Asn 
        355                 360                 365             


Arg Ile Glu Arg Pro Ile Ser Arg Glu Thr Ala Asp Ser His Glu Asn 
    370                 375                 380                 


Asn Met Asp Gly Pro Ile Ser Leu Ile Arg Pro Lys Ser Arg Pro Gln 
385                 390                 395                 400 


Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys Leu Asp Ser Thr Asp Ser 
                405                 410                 415     


Glu Ser Ser His Asp Asp His Gln Ser Tyr Gln Gly His Pro Ala Leu 
            420                 425                 430         


Asn Pro Lys Arg Lys Gln Ser Pro Ala Tyr Met Lys Glu Asp Val Lys 
        435                 440                 445             


Ala Leu Asp Thr Thr Lys Ala Pro Lys Gly Ser Leu Lys Asp Ile Tyr 
    450                 455                 460                 


Lys Val Phe Asn Gly Glu Gly Glu Gln Ile Arg Ala Phe Lys Cys Glu 
465                 470                 475                 480 


His Cys Arg Val Leu Phe Leu Asp His Val Met Tyr Thr Ile His Met 
                485                 490                 495     


Gly Cys His Gly Tyr Arg Asp Pro Leu Glu Cys Asn Ile Cys Gly Tyr 
            500                 505                 510         


Arg Ser Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Val Arg Gly Glu 
        515                 520                 525             


His Thr Phe His 
    530         


<210>  8895
<211>  2006
<212>  DNA
<213>  Homosapiens

<400>  8895
aaccctgctc ctcgctgaag atggaggaag taaaaacagg attaccctta gctacagatc     60

cactgcctta gtttccacca ccaactgcag tgcacaaaca cacgttaggc acaggaaaga    120

aagaaagaca gaggacacat taacagtaaa cacaaacaaa agggtgatgg gattatttta    180

ctgcatgcac tgctgagccc gacattgtca cctcctcttt gaggggttag aagaagctga    240

gatctcccga cagagctgga aatggtgatg aatctttttt aatcaaagga caatttcttt    300

tcattgcact ttgactatgg aaacagaggc tattgatggc tatataacgt gtgacaatga    360

gctttcaccc gaaagggagc actccaatat ggcaattgac ctcacctcaa gcacacccaa    420

tggacagcat gcctcaccaa gtcacatgac aagcacaaat tcagtaaagc tagaaatgca    480

gagtgatgaa gagtgtgaca ggaaacccct gagccgtgaa gatgagatca ggggccatga    540

tgagggtagc agcctagaag aacccctaat tgagagcagc gaggtggctg acaacaggaa    600

agtccaggag cttcaaggcg agggaggaat ccggcttccg aatggtgaac gccccttcca    660

ctgtaaccag tgtggagctt cttttactca gaagggcaac cttctgagac acataaagtt    720

acactctgga gagaagccgt tcaaatgtcc tttctgtagc tacgcctgta gaagaaggga    780

cgccctcaca ggacacctca ggacccattc tgtgggtaaa cctcacaagt gcaactactg    840

tggacgaagc tacaagcagc gcagttcact ggaggagcac aaggaacgct gccacaacta    900

tctccagaat gtcagcatgg aggctgctgg gcaggtcatg agtcaccatg tacctcctat    960

ggaagattgt aaggaacaag agcctattat ggacaacaat atttctctgg tgccttttga   1020

gagacctgct gtcatagaga agctcacggg gaatatggga aaacgtaaaa gctccactcc   1080

acaaaagttt gtgggggaaa agctcatgcg attcagctac ccagatattc actttgatat   1140

gaacttaaca tatgagaagg aggctgagct gatgcagtct catatgatgg accaagccat   1200

caacaatgca atcacctacc ttggagctga ggcccttcac cctctgatgc agcacccgcc   1260

aagcacaatc gctgaagtgg ccccagttat aagctcagct tattctcagg tctatcatcc   1320

aaataggata gaaagaccca ttagcaggga aactgctgat agtcatgaaa acaacatgga   1380

tggccccatc tctctcatca gaccaaagag tcgaccccag gaaagagagg cctctcccag   1440

caatagctgc ctggattcca ctgactcaga aagcagccat gatgaccacc agtcctacca   1500

aggacaccct gccttaaatc ccaagaggaa acaaagccca gcttacatga aggaggatgt   1560

caaagctttg gatactacca aggctcctaa gggctctctg aaggacatct acaaggtctt   1620

caatggagaa ggagaacaga ttagggcctt caagtgtgag cactgccgag tccttttcct   1680

agaccatgtc atgtacacca ttcacatggg ttgccatggc taccgggacc cactggaatg   1740

caacatctgt ggctacagaa gccaggaccg ttatgagttt tcatcacaca ttgttcgagg   1800

ggagcacaca ttccactagg ccttttcatt ccaaagggga cccctatgaa gtaaagaact   1860

gcacatgaag aaatactgca cttacaatcc cacctttcct caaatgttga catacctttt   1920

atttttttta atattattac tgttgataat tcttattttg tggaggcagt gtcatttgct   1980

ctgcctaatt acgataagga agaaac                                        2006


<210>  8896
<211>  500
<212>  PRT
<213>  Homosapiens

<400>  8896

Met Glu Thr Glu Ala Ile Asp Gly Tyr Ile Thr Cys Asp Asn Glu Leu 
1               5                   10                  15      


Ser Pro Glu Arg Glu His Ser Asn Met Ala Ile Asp Leu Thr Ser Ser 
            20                  25                  30          


Thr Pro Asn Gly Gln His Ala Ser Pro Ser His Met Thr Ser Thr Asn 
        35                  40                  45              


Ser Val Lys Leu Glu Met Gln Ser Asp Glu Glu Cys Asp Arg Lys Pro 
    50                  55                  60                  


Leu Ser Arg Glu Asp Glu Ile Arg Gly His Asp Glu Gly Ser Ser Leu 
65                  70                  75                  80  


Glu Glu Pro Leu Ile Glu Ser Ser Glu Val Ala Asp Asn Arg Lys Val 
                85                  90                  95      


Gln Glu Leu Gln Gly Glu Gly Gly Ile Arg Leu Pro Asn Gly Glu Arg 
            100                 105                 110         


Pro Phe His Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
        115                 120                 125             


Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys 
    130                 135                 140                 


Pro Phe Cys Ser Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His 
145                 150                 155                 160 


Leu Arg Thr His Ser Val Gly Lys Pro His Lys Cys Asn Tyr Cys Gly 
                165                 170                 175     


Arg Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys 
            180                 185                 190         


His Asn Tyr Leu Gln Asn Val Ser Met Glu Ala Ala Gly Gln Val Met 
        195                 200                 205             


Ser His His Val Pro Pro Met Glu Asp Cys Lys Glu Gln Glu Pro Ile 
    210                 215                 220                 


Met Asp Asn Asn Ile Ser Leu Val Pro Phe Glu Arg Pro Ala Val Ile 
225                 230                 235                 240 


Glu Lys Leu Thr Gly Asn Met Gly Lys Arg Lys Ser Ser Thr Pro Gln 
                245                 250                 255     


Lys Phe Val Gly Glu Lys Leu Met Arg Phe Ser Tyr Pro Asp Ile His 
            260                 265                 270         


Phe Asp Met Asn Leu Thr Tyr Glu Lys Glu Ala Glu Leu Met Gln Ser 
        275                 280                 285             


His Met Met Asp Gln Ala Ile Asn Asn Ala Ile Thr Tyr Leu Gly Ala 
    290                 295                 300                 


Glu Ala Leu His Pro Leu Met Gln His Pro Pro Ser Thr Ile Ala Glu 
305                 310                 315                 320 


Val Ala Pro Val Ile Ser Ser Ala Tyr Ser Gln Val Tyr His Pro Asn 
                325                 330                 335     


Arg Ile Glu Arg Pro Ile Ser Arg Glu Thr Ala Asp Ser His Glu Asn 
            340                 345                 350         


Asn Met Asp Gly Pro Ile Ser Leu Ile Arg Pro Lys Ser Arg Pro Gln 
        355                 360                 365             


Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys Leu Asp Ser Thr Asp Ser 
    370                 375                 380                 


Glu Ser Ser His Asp Asp His Gln Ser Tyr Gln Gly His Pro Ala Leu 
385                 390                 395                 400 


Asn Pro Lys Arg Lys Gln Ser Pro Ala Tyr Met Lys Glu Asp Val Lys 
                405                 410                 415     


Ala Leu Asp Thr Thr Lys Ala Pro Lys Gly Ser Leu Lys Asp Ile Tyr 
            420                 425                 430         


Lys Val Phe Asn Gly Glu Gly Glu Gln Ile Arg Ala Phe Lys Cys Glu 
        435                 440                 445             


His Cys Arg Val Leu Phe Leu Asp His Val Met Tyr Thr Ile His Met 
    450                 455                 460                 


Gly Cys His Gly Tyr Arg Asp Pro Leu Glu Cys Asn Ile Cys Gly Tyr 
465                 470                 475                 480 


Arg Ser Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Val Arg Gly Glu 
                485                 490                 495     


His Thr Phe His 
            500 


<210>  8897
<211>  442
<212>  DNA
<213>  Homosapiens

<400>  8897
gcactttgac tatggaaaca gaggctattg atggctatat aacgtgtgac aatgagcttt     60

cacccgaaag ggagcactcc aatatggcaa ttgacctcac ctcaagcaca cccaatggac    120

agcatgcctc accaagtcac atgacaagca gtaagtcttc attttatgat ttttttttgt    180

gtgtgtgtgt ctctccagca acagacttta atttgttagg tctgtggggt cctctcacat    240

tgtggtatag ctactgttat agattttgct aaagaaagaa caacacagat ttattcctgt    300

tcattctagt attataaaac atgagcctgc ttactagtct gaactatccc aaggtggcat    360

ttgggagctg gtgcttacct gtatcaggta agaaaggtta gaatttgctg gttgttgttt    420

tgacttgcca ggtttatgac tg                                             442


<210>  8898
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  8898

Met Glu Thr Glu Ala Ile Asp Gly Tyr Ile Thr Cys Asp Asn Glu Leu 
1               5                   10                  15      


Ser Pro Glu Arg Glu His Ser Asn Met Ala Ile Asp Leu Thr Ser Ser 
            20                  25                  30          


Thr Pro Asn Gly Gln His Ala Ser Pro Ser His Met Thr Ser Ser Lys 
        35                  40                  45              


Ser Ser Phe Tyr Asp Phe Phe Leu Cys Val Cys Val Ser Pro Ala Thr 
    50                  55                  60                  


Asp Phe Asn Leu Leu Gly Leu Trp Gly Pro Leu Thr Leu Trp Tyr Ser 
65                  70                  75                  80  


Tyr Cys Tyr Arg Phe Cys 
                85      


<210>  8899
<211>  460
<212>  DNA
<213>  Homosapiens

<400>  8899
aaaaccgata acttctttta tttttgtcag gtgatgttgt tcttgtcttt gaagtagtgt     60

tctcttttta agcgggatat ggaacaatgg tctcacttac tcctgttgac ctagattggc    120

accagtgttt gtgagaagct tcaactcttt ataaaccaaa attctttcac agtaaagcaa    180

agtctaatca cttgcttaac aatcctgtta agccgcaagt ctttggaaat attgccttca    240

gaggtcattc ttgatgtgag ggggacactg caggctgtca ggcctggtac cattaggcag    300

tctatcgtac acaaaactct ttgatcagtt ctaagcccaa cattagcgac tttctgatat    360

tttcactctc catgtgattt tcctgcttct gtaattgtgc atgcataaag tatgcctgaa    420

ggctttggaa agagagattc tgcaaactga atactaattt                          460


<210>  8900
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  8900

Ile Gly Thr Ser Val Cys Glu Lys Leu Gln Leu Phe Ile Asn Gln Asn 
1               5                   10                  15      


Ser Phe Thr Val Lys Gln Ser Leu Ile Thr Cys Leu Thr Ile Leu Leu 
            20                  25                  30          


Ser Arg Lys Ser Leu Glu Ile Leu Pro Ser Glu Val Ile Leu Asp Val 
        35                  40                  45              


Arg Gly Thr Leu Gln Ala Val Arg Pro Gly Thr Ile Arg Gln Ser Ile 
    50                  55                  60                  


Val His Lys Thr Leu 
65                  


<210>  8901
<211>  576
<212>  DNA
<213>  Homosapiens

<400>  8901
ggaaatattg ccttcagagg tcattcttga tgtgaggggg acactgcagg ctgtcaggcc     60

tggtaccatt aggcagtcta tcgtacacaa aactctttga tcagttctaa gcccaacatt    120

agcgactttc tgatattttc actctccatg tgattttcct gactgtttta ctctgattgg    180

gtgacttcat tgctcttgtc cttgtttctt cctatgtgaa atgaagggat aataccagag    240

aatgatcaaa gagtcaggct gcttctgtaa ttgtgcatgc ataaagtatg cctgaaggct    300

ttggaaagag agattctgca aactgaatac taattttgtg aatactgtaa tttcatgtct    360

gccatccatg ttcaagccgg ttgtggcttg aggagcagct gaggctttat ggaaaacttt    420

gtaaaacatt ctatttagaa gcaattcttg ttctttgcat tatgtgctct gggtattttt    480

cttcctttgt gttttatttt gagcgcattt gtatgaaaac aagatctttg tttcttacaa    540

gcacatctgc tcttgctgct tatagattag gagaag                              576


<210>  8902
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  8902

Met Cys Ser Gly Tyr Phe Ser Ser Phe Val Phe Tyr Phe Glu Arg Ile 
1               5                   10                  15      


Cys Met Lys Thr Arg Ser Leu Phe Leu Thr Ser Thr Ser Ala Leu Ala 
            20                  25                  30          


Ala Tyr Arg Leu Gly 
        35          


<210>  8903
<211>  1727
<212>  DNA
<213>  Homosapiens

<400>  8903
attgcacctt cctacccaag cagcttggtt ttctttcgct ttgaccctgt aatttctttc     60

ccacttcgtt gtcgtctctg aattaccttt ctcttgattc ttgcccatta gcatcctcca    120

atttcagatg tttgtagatc cccaagtgtt cccagggaaa actactagaa aaggtcaagc    180

tgatgcaaga gatggtttcc catggtcttg ggcagctcca cccctgtggc tttgcagggt    240

acaatctccc tcctggctgc tttcatgggc tggcattgag tgtctgcagc ttttccaggt    300

gcacagtgca agctatcggt ggatctacct ttctggggcc tgtgatgaga agggctgccg    360

tgaagacctc tcacatgccc tggaggcatt tttcctattg tcttggggat taacattcgg    420

ttacttgtta cttacgcaaa tttctgcaac tggcttgaat ttctcgtcag aaaatgggat    480

ttttcttttc tatcacattg tcaggctgca aattttccga acatttatgc tctgcttccc    540

ttataaaact gaatgccttt aacagcaccc aagtcacctc ttgaatgctt tgctgcttag    600

aaatttcttc tgccagatac cctaaattat ctctctcaag ttcaaagttc gacaaatctc    660

tagggcaggg gcaaaatgcc actaatctct ttattaaaac ataacaagag ccacctttgc    720

tccagttccc aacaaggtcc tcatctccat ctgagattac ctcagcctgg atttcattgt    780

ccatattgct atcagcattt tgggcaaagc cattcaacaa gtctctagga agttccaaac    840

tctccgacat tttcctgtct tctgagccct ccaagctgtt ccaacctctg cctattacaa    900

agttccaaag ttgctttcac atttttggct gtcttttcag caacacccca ctcctggaac    960

caatttactg tattagtctg ttttcatgct gctaataaaa acatacctga gactgggcaa   1020

tttacaaaat aaagaggttt aattggactc acagttccac gtggctgagg aggcctcaga   1080

atcatggtgg aaggcaagga ggagcaagtc acatcttata tcaatgtcag caggcaaaga   1140

gagcttgtgc agggaactcc tgttttgaaa accatcagat cttgtgtgac ttattcacta   1200

ccacaagaac agtatggggg aaaccacccc catgatttaa ttttctccca cagaattttt   1260

ccctcaacat gtgagaatta tgggagtaca attcaagatg atatttgggt gggacacagc   1320

caaaccatat caatcatcaa acaagaaaag agggaaactt tcacaaccaa gagatcccta   1380

aagaggtatg ctgactgaat gtaatgtggg atcctagggc aaaaagaata ttatgtaaaa   1440

acgaaggata tctgaataaa gtatggactt tatttagtta ataataatgt gtcaataatg   1500

gttcattaga tgtaacaaat gcaccatatt gatgtaagat gttcaaagta gggaaaactg   1560

aatatgagta tatgggaact ttctttatct ttgcaacttc ttggtacatc taaaactatt   1620

ctgaaataaa aaaattttta aagagttgct tgaaccttta ttctaacatt tccttaaaca   1680

agcctcacca ttgacctttc ttttaaaaca ataaattcct tttgctt                 1727


<210>  8904
<211>  144
<212>  PRT
<213>  Homosapiens

<400>  8904

Met Phe Val Asp Pro Gln Val Phe Pro Gly Lys Thr Thr Arg Lys Gly 
1               5                   10                  15      


Gln Ala Asp Ala Arg Asp Gly Phe Pro Trp Ser Trp Ala Ala Pro Pro 
            20                  25                  30          


Leu Trp Leu Cys Arg Val Gln Ser Pro Ser Trp Leu Leu Ser Trp Ala 
        35                  40                  45              


Gly Ile Glu Cys Leu Gln Leu Phe Gln Val His Ser Ala Ser Tyr Arg 
    50                  55                  60                  


Trp Ile Tyr Leu Ser Gly Ala Cys Asp Glu Lys Gly Cys Arg Glu Asp 
65                  70                  75                  80  


Leu Ser His Ala Leu Glu Ala Phe Phe Leu Leu Ser Trp Gly Leu Thr 
                85                  90                  95      


Phe Gly Tyr Leu Leu Leu Thr Gln Ile Ser Ala Thr Gly Leu Asn Phe 
            100                 105                 110         


Ser Ser Glu Asn Gly Ile Phe Leu Phe Tyr His Ile Val Arg Leu Gln 
        115                 120                 125             


Ile Phe Arg Thr Phe Met Leu Cys Phe Pro Tyr Lys Thr Glu Cys Leu 
    130                 135                 140                 


<210>  8905
<211>  2362
<212>  DNA
<213>  Homosapiens

<400>  8905
gccggaatct cgcgagagct cccgggggcc gttgggtagc gtcttcgctg ttgcccttag     60

ggacggctgt gggcctgctg ggggtggggg cccgaagcgc cagagatggc tgctcagcga    120

gggatgccca gctccgccgt gagggtcctg gaagaggcgt tgggcatggg tttgacggca    180

gccggggacg cgagggacac ggcggacgcg gtggcggctg agggcgccta ctacctggaa    240

ccttatctat atccagtgcc cttgctactg aatgattaaa acttgacaag atattcagag    300

gtcaccataa ctgaagcatc tgaagatgac tatgaatatg aagagataaa agcagttgcc    360

cacaaactaa tcctgaattt attagaagtg acgtttattg acatttacaa ggaagtcaga    420

agaaagcagt tattcatttt tcatggatct tcagaatgac atgataccag atgacaattt    480

tagcatccca gaaggtgaag aagatctggc aaaagcaatt cagatggccc aagaacaggc    540

tacagatact gaaattttgg aacggaaaac agttcttcct tcaaagcatg cagtacctga    600

agtaatagaa gactttctct gcaatttctt gatcaaaatg ggaatgacca gaactcttga    660

ttgctttcag tctgaatggt atgagttaat acagaaagga gtgactgaac ttagaactgt    720

tgggaatgtt ccagatgtct acacccagat tatgcttttg gaaaatgaga acaaaaattt    780

aaagaaagat ttgaagcact acaaacaagc agctgacaaa gctagagaag atttgctgaa    840

aattcagaaa gaacgtgatt ttcatcgaat gcatcataag cgaatagtcc aggaaaaaaa    900

caaattaatt aatgacctca aagggttgaa gttacattat gcatcttatg aaccgactat    960

aagggtgtta catgagaaac accacacttt actgaaggag aaaatgctga cctccttgga   1020

aagagacaaa gtagttgggc agatttctgg acttcaagaa acattgaaga aactgcaaag   1080

aggacatagt taccatggtc ctcaaattaa agttgatcat agtcgtgaaa aagaaaatgc   1140

accagaaggt cctactcaga aaggtcttcg tgaagccagg gaacaaaaca aatgtaaaac   1200

aaagatgaaa ggcaatacaa aggattcaga atttcccata gatatgcaac caaatccaaa   1260

cctgaatgtt tctaaagaaa gtctttctcc agcaaaattt gactacaagc tgaaaaacat   1320

ttttagactc catgaacttc cagtgagctg tgtctccatg caaccccaca aagacatcct   1380

agtctcctgt ggcgaggacc gactctggaa ggtgttgggc cttccaaaat gcaatgtgct   1440

tctcacggga tttggccaca ctgactggct ttcagactgc tgcttccatc ccagtggcga   1500

caaattggct acttcaagtg gtgacactac agttaaatta tgggatctat gtaaaggcga   1560

ttgcattttg acctttgaag gacacagccg cgcagtgtgg tcctgcacat ggcactcctg   1620

cggcaatttt gtggcttcct cctcactgga taaaactagc aaaatttggg atgttaatag   1680

tgaaagatgc agatgtactt tgtatggaca tacagattct gtgaacagca ttgagttttt   1740

tcctttctcc aatactcttc tcacaagctc tgcagacaag accctgtcta tatgggatgc   1800

aagaacaggt atatgtgagc agtcacttta tggtcacatg cattctatca atgatgccat   1860

ttttgatccc aggggtcaca tgatagcatc ctgtgatgcc tgtggggtta caaagctgtg   1920

ggactttcgg aagctgttac caattgtgtc catcgatata ggtccaagtc ctggcaatga   1980

ggtgaatttt gattcatcag gtcgagtttt agctcaggca agtggcaatg gtgttatcca   2040

tttgctagat cttaaatctg gggagattca caaattgatg ggccacgaaa acgaggcaca   2100

cacggttgtg ttttctcacg acggggagat tctcttttct ggaggctctg acggcacagt   2160

tcgaacgtgg tcttgaccgt cagcacatcc cgctgcagag ggcattccct ttaaggcttg   2220

aaaatgcctc ctgtagtccc aaaccagcaa agaactggtt aaatgtgcca gcaggtaaca   2280

tttacagtct gctttaaaac atgctttgga catatatttt agtgctcata ctgttactaa   2340

taaaaaaata actttatgct ca                                            2362


<210>  8906
<211>  577
<212>  PRT
<213>  Homosapiens

<400>  8906

Met Asp Leu Gln Asn Asp Met Ile Pro Asp Asp Asn Phe Ser Ile Pro 
1               5                   10                  15      


Glu Gly Glu Glu Asp Leu Ala Lys Ala Ile Gln Met Ala Gln Glu Gln 
            20                  25                  30          


Ala Thr Asp Thr Glu Ile Leu Glu Arg Lys Thr Val Leu Pro Ser Lys 
        35                  40                  45              


His Ala Val Pro Glu Val Ile Glu Asp Phe Leu Cys Asn Phe Leu Ile 
    50                  55                  60                  


Lys Met Gly Met Thr Arg Thr Leu Asp Cys Phe Gln Ser Glu Trp Tyr 
65                  70                  75                  80  


Glu Leu Ile Gln Lys Gly Val Thr Glu Leu Arg Thr Val Gly Asn Val 
                85                  90                  95      


Pro Asp Val Tyr Thr Gln Ile Met Leu Leu Glu Asn Glu Asn Lys Asn 
            100                 105                 110         


Leu Lys Lys Asp Leu Lys His Tyr Lys Gln Ala Ala Asp Lys Ala Arg 
        115                 120                 125             


Glu Asp Leu Leu Lys Ile Gln Lys Glu Arg Asp Phe His Arg Met His 
    130                 135                 140                 


His Lys Arg Ile Val Gln Glu Lys Asn Lys Leu Ile Asn Asp Leu Lys 
145                 150                 155                 160 


Gly Leu Lys Leu His Tyr Ala Ser Tyr Glu Pro Thr Ile Arg Val Leu 
                165                 170                 175     


His Glu Lys His His Thr Leu Leu Lys Glu Lys Met Leu Thr Ser Leu 
            180                 185                 190         


Glu Arg Asp Lys Val Val Gly Gln Ile Ser Gly Leu Gln Glu Thr Leu 
        195                 200                 205             


Lys Lys Leu Gln Arg Gly His Ser Tyr His Gly Pro Gln Ile Lys Val 
    210                 215                 220                 


Asp His Ser Arg Glu Lys Glu Asn Ala Pro Glu Gly Pro Thr Gln Lys 
225                 230                 235                 240 


Gly Leu Arg Glu Ala Arg Glu Gln Asn Lys Cys Lys Thr Lys Met Lys 
                245                 250                 255     


Gly Asn Thr Lys Asp Ser Glu Phe Pro Ile Asp Met Gln Pro Asn Pro 
            260                 265                 270         


Asn Leu Asn Val Ser Lys Glu Ser Leu Ser Pro Ala Lys Phe Asp Tyr 
        275                 280                 285             


Lys Leu Lys Asn Ile Phe Arg Leu His Glu Leu Pro Val Ser Cys Val 
    290                 295                 300                 


Ser Met Gln Pro His Lys Asp Ile Leu Val Ser Cys Gly Glu Asp Arg 
305                 310                 315                 320 


Leu Trp Lys Val Leu Gly Leu Pro Lys Cys Asn Val Leu Leu Thr Gly 
                325                 330                 335     


Phe Gly His Thr Asp Trp Leu Ser Asp Cys Cys Phe His Pro Ser Gly 
            340                 345                 350         


Asp Lys Leu Ala Thr Ser Ser Gly Asp Thr Thr Val Lys Leu Trp Asp 
        355                 360                 365             


Leu Cys Lys Gly Asp Cys Ile Leu Thr Phe Glu Gly His Ser Arg Ala 
    370                 375                 380                 


Val Trp Ser Cys Thr Trp His Ser Cys Gly Asn Phe Val Ala Ser Ser 
385                 390                 395                 400 


Ser Leu Asp Lys Thr Ser Lys Ile Trp Asp Val Asn Ser Glu Arg Cys 
                405                 410                 415     


Arg Cys Thr Leu Tyr Gly His Thr Asp Ser Val Asn Ser Ile Glu Phe 
            420                 425                 430         


Phe Pro Phe Ser Asn Thr Leu Leu Thr Ser Ser Ala Asp Lys Thr Leu 
        435                 440                 445             


Ser Ile Trp Asp Ala Arg Thr Gly Ile Cys Glu Gln Ser Leu Tyr Gly 
    450                 455                 460                 


His Met His Ser Ile Asn Asp Ala Ile Phe Asp Pro Arg Gly His Met 
465                 470                 475                 480 


Ile Ala Ser Cys Asp Ala Cys Gly Val Thr Lys Leu Trp Asp Phe Arg 
                485                 490                 495     


Lys Leu Leu Pro Ile Val Ser Ile Asp Ile Gly Pro Ser Pro Gly Asn 
            500                 505                 510         


Glu Val Asn Phe Asp Ser Ser Gly Arg Val Leu Ala Gln Ala Ser Gly 
        515                 520                 525             


Asn Gly Val Ile His Leu Leu Asp Leu Lys Ser Gly Glu Ile His Lys 
    530                 535                 540                 


Leu Met Gly His Glu Asn Glu Ala His Thr Val Val Phe Ser His Asp 
545                 550                 555                 560 


Gly Glu Ile Leu Phe Ser Gly Gly Ser Asp Gly Thr Val Arg Thr Trp 
                565                 570                 575     


Ser 
    


<210>  8907
<211>  1256
<212>  DNA
<213>  Homosapiens

<400>  8907
gagagctccc gggggccgtt gggtagcgtc ttcgctgttg cccttaggga cggctgtggg     60

cctgctgggg gtgggggccc gaagcgccag agatggctgc tcagcgaggg atgcccagct    120

ccgccgtgag ggtcctggaa gaggcgttgg gcatgggttt gacggcagcc ggggacgcga    180

gggacacggc ggacgcggtg gcggctgagg gcgcctacta cctggaacag gtcaccataa    240

ctgaagcatc tgaagatgac tatgaatatg aagagatacc agatgacaat tttagcatcc    300

cagaaggtga agaagatctg gcaaaagcaa ttcagatggc ccaagaacag gctacagata    360

ctgaaatttt ggaacggaaa acagttcttc cttcaaagca tgcagtacct gaagtaatag    420

aagactttct ctgcaatttc ttgatcaaaa tgggaatgac cagaactctt gattgctttc    480

agtctgaatg gtatgagtta atacagaaag gagtgactga acttagaact gttgggaatg    540

ttccagatgt ctacacccag attatgcttt tggaaaatga gaacaaaaat ttaaagaaag    600

atttgaagca ctacaaacaa gcagctgagt atgttatttt ttaaatgaca ttttcttctt    660

tttcttttgg actaaataaa agagttgagt gaagctgata tatgtaatat accagagcct    720

taatttttga aaactgaatt tttctagttg taaagaatgt gagaggcttc attagcaaat    780

taattaaaca gatgatcaga actatcacaa ttataactta ccaacaagaa gggaatgcag    840

gtagttgttt aggagatggt acatttttta tataacattc acttccttgt gtatttgata    900

gtcttttcat ggtttataac attttctcct gtaaagatag gctaatttct gaaataataa    960

ttaaatttat agaaagccga gaggaaattg ctagtttatt cctggtagag gaatttctgt   1020

atttgaaaat tctccagaag gaataatata aactgtggac tttgggtgat aatgatatgt   1080

aggttcgtca gttgttaaca aatgtatccc tctgttgggg gctattgata atggggaagg   1140

ctgtgcatgt gtgggagtag gaggtgtatg ggacatctct gtaccttcta atcaattttg   1200

ctatgaactt aaaactgctc taaaaataaa gtttattaaa aaaaagttaa ttctct       1256


<210>  8908
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  8908

Met Ala Ala Gln Arg Gly Met Pro Ser Ser Ala Val Arg Val Leu Glu 
1               5                   10                  15      


Glu Ala Leu Gly Met Gly Leu Thr Ala Ala Gly Asp Ala Arg Asp Thr 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Glu Gly Ala Tyr Tyr Leu Glu Gln Val Thr 
        35                  40                  45              


Ile Thr Glu Ala Ser Glu Asp Asp Tyr Glu Tyr Glu Glu Ile Pro Asp 
    50                  55                  60                  


Asp Asn Phe Ser Ile Pro Glu Gly Glu Glu Asp Leu Ala Lys Ala Ile 
65                  70                  75                  80  


Gln Met Ala Gln Glu Gln Ala Thr Asp Thr Glu Ile Leu Glu Arg Lys 
                85                  90                  95      


Thr Val Leu Pro Ser Lys His Ala Val Pro Glu Val Ile Glu Asp Phe 
            100                 105                 110         


Leu Cys Asn Phe Leu Ile Lys Met Gly Met Thr Arg Thr Leu Asp Cys 
        115                 120                 125             


Phe Gln Ser Glu Trp Tyr Glu Leu Ile Gln Lys Gly Val Thr Glu Leu 
    130                 135                 140                 


Arg Thr Val Gly Asn Val Pro Asp Val Tyr Thr Gln Ile Met Leu Leu 
145                 150                 155                 160 


Glu Asn Glu Asn Lys Asn Leu Lys Lys Asp Leu Lys His Tyr Lys Gln 
                165                 170                 175     


Ala Ala Glu Tyr Val Ile Phe 
            180             


<210>  8909
<211>  689
<212>  DNA
<213>  Homosapiens

<400>  8909
ccgggggccg ttgggtagcg tcttcgctgt tgcccttagg gacggctgtg ggcctgctgg     60

gggtgggggc ccgaagcgcc agagatggct gctcagcgag ggatgcccag ctccgccgtg    120

agggtcctgg aagaggcgtt gggcatgggt ttgacggcag ccggggacgc gagggacacg    180

gcggacgcgg tggcggctga gggcgcctac tacctggaac aggtcaccat aactgaagca    240

tctgaagatg actatgaata tgaagagata ccagatgaca attttagcat cccagaaggt    300

gaagaagatc tggcaaaagc aattcagatg gcccaagaac aggctacaga tactgaaatt    360

ttggaacgga aaacagttct tccttcaaag catgcagtac ctgaagtaat agaagacttt    420

ctctgcaatt tcttgatcaa aatgggaatg accagaactc ttgattgctt tcagtctgaa    480

tggtatgagt taatacagaa aggagtgact gaacttagaa ctgttgggaa tgttccagat    540

gtctacaccc agattatgct tttggaaaat gagaacaaaa atttaaagaa agatttgaag    600

cactacaaac aagcagctga gtatgttatt ttttaaatga cattttcttc tttttctttt    660

ggactaaata aaagagttga gtgaagctg                                      689


<210>  8910
<211>  183
<212>  PRT
<213>  Homosapiens

<400>  8910

Met Ala Ala Gln Arg Gly Met Pro Ser Ser Ala Val Arg Val Leu Glu 
1               5                   10                  15      


Glu Ala Leu Gly Met Gly Leu Thr Ala Ala Gly Asp Ala Arg Asp Thr 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Glu Gly Ala Tyr Tyr Leu Glu Gln Val Thr 
        35                  40                  45              


Ile Thr Glu Ala Ser Glu Asp Asp Tyr Glu Tyr Glu Glu Ile Pro Asp 
    50                  55                  60                  


Asp Asn Phe Ser Ile Pro Glu Gly Glu Glu Asp Leu Ala Lys Ala Ile 
65                  70                  75                  80  


Gln Met Ala Gln Glu Gln Ala Thr Asp Thr Glu Ile Leu Glu Arg Lys 
                85                  90                  95      


Thr Val Leu Pro Ser Lys His Ala Val Pro Glu Val Ile Glu Asp Phe 
            100                 105                 110         


Leu Cys Asn Phe Leu Ile Lys Met Gly Met Thr Arg Thr Leu Asp Cys 
        115                 120                 125             


Phe Gln Ser Glu Trp Tyr Glu Leu Ile Gln Lys Gly Val Thr Glu Leu 
    130                 135                 140                 


Arg Thr Val Gly Asn Val Pro Asp Val Tyr Thr Gln Ile Met Leu Leu 
145                 150                 155                 160 


Glu Asn Glu Asn Lys Asn Leu Lys Lys Asp Leu Lys His Tyr Lys Gln 
                165                 170                 175     


Ala Ala Glu Tyr Val Ile Phe 
            180             


<210>  8911
<211>  4059
<212>  DNA
<213>  Homosapiens

<400>  8911
ccgggggccg ttgggtagcg tcttcgctgt tgcccttagg gacggctgtg ggcctgctgg     60

gggtgggggc ccgaagcgcc agagatggct gctcagcgag ggatgcccag ctccgccgtg    120

agggtcctgg aagaggcgtt gggcatgggt ttgacggcag ccggggacgc gagggacacg    180

gcggacgcgg tggcggctga gggcgcctac tacctggaac aggtcaccat aactgaagca    240

tctgaagatg actatgaata tgaagagata ccagatgaca attttagcat cccagaaggt    300

gaagaagatc tggcaaaagc aattcagatg gcccaagaac aggctacaga tactgaaatt    360

ttggaacgga aaacagttct tccttcaaag catgcagtac ctgaagtaat agaagacttt    420

ctctgcaatt tcttgatcaa aatgggaatg accagaactc ttgattgctt tcagtctgaa    480

tggtatgagt taatacagaa aggagtgact gaacttagaa ctgttgggaa tgttccagat    540

gtctacaccc agattatgct tttggaaaat gagaacaaaa atttaaagaa agatttgaag    600

cactacaaac aagcagctga caaagctaga gaagatttgc tgaaaattca gaaagaacgt    660

gattttcatc gaatgcatca taagcgaata gtccaggaaa aaaacaaatt aattaatgac    720

ctcaaagggt tgaagttaca ttatgcatct tatgaaccga ctataagggt gttacatgag    780

aaacaccaca ctttactgaa ggagaaaatg ctgacctcct tggaaagaga caaagtagtt    840

gggcagattt ctggacttca agaaacattg aagaaactgc aaagaggaca tagttaccat    900

ggtcctcaaa ttaaagttga tcatagtcgt gaaaaagaaa atgcaccaga aggtcctact    960

cagaaaggtc ttcgtgaagc cagggaacaa aacaaatgta aaacaaagat gaaaggcaat   1020

acaaagcagt ggacagggaa ctctcaaact tggaataaga ccgtacctct gcaggacact   1080

attggcagga gacaagagaa caacagtgca caccagcaca tcgactaaga ctgcccatct   1140

tcaggacatt tgtcagcagg agccaaatgg gaaattctga gcaacaggtg ttcctggctt   1200

gttctcctcc aatcctccct ttcgtcaaca cccataccct ttatctgtgt tctttacagt   1260

cttcataaaa ggagtccagg acttccagtt aatcatttat cccagaactc taatcctccg   1320

taaggatcct ttttttttga cccaatattt ccctcttctg actccccaaa ccctttcttt   1380

gtactctatt gaattcaagg tcagtcaaca aaaaagtcct ttatatttta atattttact   1440

atgagtgttc ccttcacctt ctgtgctaat gaaaatctag attttccttc atgatagttt   1500

cccctgcatc cattgaggtt ctggtaaatg ttttaacaat caactctttg gaagaagaaa   1560

acaaaagcct tgatttgtat agtgttttcc agtttctgtg ctgttaaaca ctcacaccat   1620

agccatttaa gctatcttct cacttcactg aataaggagc ctgggacttg atgtccacac   1680

tcagctctcc taagccagta tgagagagca acaacacatc acatcttaca gtacctttaa   1740

gggtaactgt tctctctact ccactcaaat gtagcatagg tcctgaaagt cagataagtg   1800

tcccctttgc ttctcattgc tgctttcagt ttgttctccc tccttcatga acataccctt   1860

ccgtgaatct catgtcatca gatttgccca ctcattgtac ctttttgtta tgggcacctc   1920

ttctcacctc atctttttgt caattaaaaa aattaatccc cgtgatattg tcactttctt   1980

aaaagtgatt cctccataat gcttcatgat tgaaatgttg atatggatga tccttctaac   2040

tctctgaagt ttcagttcct tgacagcctc tcctccagtg atccacttaa ctcactttca   2100

tagtcatttc ctaggccttg ttattgcaag taactgctat aatttttcat tgcctctatt   2160

gtttgctccc taccccccga atctctgcat actgaggtgt ttcaaggctc agttcttgac   2220

cctctgttgg ttgtcttcac tccctaggtg atctcatcca gtcttatggc tttaaattct   2280

gcctatatat taattatccc ttaatttaca tcttcaactg agatctcttc tctgaactct   2340

agtttcatat atccaactgc ttactgaaca cctccagtta aatgtcattt cttcatttca   2400

attatctccc cttccatgtt ctccttctta attaatggaa actccacact ttagttactt   2460

agccaaaaaa ctctagagtc atccctgaga cgtctctctc tctcacatct cacatctgat   2520

aagaaaaaga aattattttg gctctatctt tgaaaaaata tctacatttt cattttttct   2580

taccactagc acttttgctc tctgtttttt tttttttgcc accgtctgta gtttgtatta   2640

ttgcaaaagc ctcctaactg atctctgctt ttgtctttac ttttcttcag tctcttttga   2700

acacagcagc cacagtcatc ttcttaaaac ataagtctgt ccatgacatt tctctgctga   2760

aaattttcca gtaacctccc atcttactga gttacaggta aggtcattat aacctctgag   2820

gccctacatt acctagatcc cttttacctc tctgacatta tctcctgcta ccctcccatc   2880

ttttgctcaa ttgcaggcac actagcctcc tacaaattct acttatttat agaacactgt   2940

aggtatgccc caccttgagg ctcttgcact tgagttttta tcttctgtct gtgttatttt   3000

ccttcagata attcagatgg ctcatctctc actttattta aagctttact caaatgttcc   3060

cttttcagag agacttttca tagccatcca atctaaattt taatgctgcc tctaattcac   3120

tggcacttct ttggcctcta tcctacttta atttttcttt ttgcctatct tacatatctc   3180

tcatatgcta tgttgtactt attaactcat tgtatcactt cccactagaa tgtaagtccc   3240

atgaaagcag gaatatttat taattgtatt cactgctata ttctcagtgc cagaaaaatg   3300

cctggcaaat agtaattatc ccataaatat gtaaatttga aggaatgcat aaattaaaaa   3360

atgtgttttg ttagttgcta ttgtatagat atgcattgat tactacaagt tgatcagaaa   3420

tagagtgttt ctgctaaacc ccctgtttct ataatttgtc tataggcttt ttgggaattt   3480

tctttgtaag tagtatcatc tgtgaaaaat aatagttgtg actttcattt ttcaattcta   3540

aaaattttta tttgtatttc ttatatttgt gctttgtcta ggtcctccag aaagttaaat   3600

agaagtggtt aaatagtggt ggttatacta tttgtgattt taaaggtgat gcatctgatg   3660

tttcaacaca aggaatgata tttattgtct ttggtggtta ttctttatca agttgaaaaa   3720

atttgttttc ctttgatatt taaagtttgt gttttaccat gagtatatta atttttttga   3780

ccataagtga ttggtaattt tatcatgttt aagttttaag attttatttt atcatgaata   3840

agtattgtat tttctgcttc tgagactgtt ttctccatta atattttaat gtggtaaatg   3900

ttgccatgga ttttaaaatg taaacattct ctttcattcc tggaataaaa ctaatgtatt   3960

catcatgtgt tatttgagtt acataacact ggacctagtt aatcattttt tcataggatg   4020

cttacttcta gtttatgaat aaaattgatc tttaatttt                          4059


<210>  8912
<211>  347
<212>  PRT
<213>  Homosapiens

<400>  8912

Met Ala Ala Gln Arg Gly Met Pro Ser Ser Ala Val Arg Val Leu Glu 
1               5                   10                  15      


Glu Ala Leu Gly Met Gly Leu Thr Ala Ala Gly Asp Ala Arg Asp Thr 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Glu Gly Ala Tyr Tyr Leu Glu Gln Val Thr 
        35                  40                  45              


Ile Thr Glu Ala Ser Glu Asp Asp Tyr Glu Tyr Glu Glu Ile Pro Asp 
    50                  55                  60                  


Asp Asn Phe Ser Ile Pro Glu Gly Glu Glu Asp Leu Ala Lys Ala Ile 
65                  70                  75                  80  


Gln Met Ala Gln Glu Gln Ala Thr Asp Thr Glu Ile Leu Glu Arg Lys 
                85                  90                  95      


Thr Val Leu Pro Ser Lys His Ala Val Pro Glu Val Ile Glu Asp Phe 
            100                 105                 110         


Leu Cys Asn Phe Leu Ile Lys Met Gly Met Thr Arg Thr Leu Asp Cys 
        115                 120                 125             


Phe Gln Ser Glu Trp Tyr Glu Leu Ile Gln Lys Gly Val Thr Glu Leu 
    130                 135                 140                 


Arg Thr Val Gly Asn Val Pro Asp Val Tyr Thr Gln Ile Met Leu Leu 
145                 150                 155                 160 


Glu Asn Glu Asn Lys Asn Leu Lys Lys Asp Leu Lys His Tyr Lys Gln 
                165                 170                 175     


Ala Ala Asp Lys Ala Arg Glu Asp Leu Leu Lys Ile Gln Lys Glu Arg 
            180                 185                 190         


Asp Phe His Arg Met His His Lys Arg Ile Val Gln Glu Lys Asn Lys 
        195                 200                 205             


Leu Ile Asn Asp Leu Lys Gly Leu Lys Leu His Tyr Ala Ser Tyr Glu 
    210                 215                 220                 


Pro Thr Ile Arg Val Leu His Glu Lys His His Thr Leu Leu Lys Glu 
225                 230                 235                 240 


Lys Met Leu Thr Ser Leu Glu Arg Asp Lys Val Val Gly Gln Ile Ser 
                245                 250                 255     


Gly Leu Gln Glu Thr Leu Lys Lys Leu Gln Arg Gly His Ser Tyr His 
            260                 265                 270         


Gly Pro Gln Ile Lys Val Asp His Ser Arg Glu Lys Glu Asn Ala Pro 
        275                 280                 285             


Glu Gly Pro Thr Gln Lys Gly Leu Arg Glu Ala Arg Glu Gln Asn Lys 
    290                 295                 300                 


Cys Lys Thr Lys Met Lys Gly Asn Thr Lys Gln Trp Thr Gly Asn Ser 
305                 310                 315                 320 


Gln Thr Trp Asn Lys Thr Val Pro Leu Gln Asp Thr Ile Gly Arg Arg 
                325                 330                 335     


Gln Glu Asn Asn Ser Ala His Gln His Ile Asp 
            340                 345         


<210>  8913
<211>  2166
<212>  DNA
<213>  Homosapiens

<400>  8913
ccgggggccg ttgggtagcg tcttcgctgt tgcccttagg gacggctgtg ggcctgctgg     60

gggtgggggc ccgaagcgcc agagatggct gctcagcgag ggatgcccag ctccgccgtg    120

agggtcctgg aagaggcgtt gggcatgggt ttgacggcag ccggggacgc gagggacacg    180

gcggacgcgg tggcggctga gggcgcctac tacctggaac aggtcaccat aactgaagca    240

tctgaagatg actatgaata tgaagagata ccagatgaca attttagcat cccagaaggt    300

gaagaagatc tggcaaaagc aattcagatg gcccaagaac aggctacaga tactgaaatt    360

ttggaacgga aaacagttct tccttcaaag catgcagtac ctgaagtaat agaagacttt    420

ctctgcaatt tcttgatcaa aatgggaatg accagaactc ttgattgctt tcagtctgaa    480

tggtatgagt taatacagaa aggagtgact gaacttagaa ctgttgggaa tgttccagat    540

gtctacaccc agattatgct tttggaaaat gagaacaaaa atttaaagaa agatttgaag    600

cactacaaac aagcagctga caaagctaga gaagatttgc tgaaaattca gaaagaacgt    660

gattttcatc gaatgcatca taagcgaata gtccaggaaa aaaacaaatt aattaatgac    720

ctcaaagggt tgaagttaca ttatgcatct tatgaaccga ctataagggt gttacatgag    780

aaacaccaca ctttactgaa ggagaaaatg ctgacctcct tggaaagaga caaagtagtt    840

gggcagattt ctggacttca agaaacattg aagaaactgc aaagaggaca tagttaccat    900

ggtcctcaaa ttaaagttga tcatagtcgt gaaaaagaaa atgcaccaga aggtcctact    960

cagaaaggtc ttcgtgaagc cagggaacaa aacaaatgta aaacaaagat gaaaggcaat   1020

acaaaggatt cagaatttcc catagatatg caaccaaatc caaacctgaa tgtttctaaa   1080

gaaagtcttt ctccagcaaa atttgactac aagctgaaaa acatttttag actccatgaa   1140

cttccagtga gctgtgtctc catgcaaccc cacaaagaca tcctagtctc ctgtggcgag   1200

gaccgactct ggaaggtgtt gggccttcca aaatgcaatg tgcttctcac gggatttggc   1260

cacactgact ggctttcaga ctgctgcttc catcccagtg gcgacaaatt ggctacttca   1320

agtggtgaca ctacagttaa attatgggat ctatgtaaag gcgattgcat tttgaccttt   1380

gaaggacaca gccgcgcagt gtggtcctgc acatggcact cctgcggcaa ttttgtggct   1440

tcctcctcac tggataaaac tagcaaaatt tgggatgtta atagtgaaag atgcagatgt   1500

actttgtatg gacatacaga ttctgtgaac agcattgagt tttttccttt ctccaatact   1560

cttctcacaa gctctgcaga caagaccctg tctatatggg atgcaagaac aggtatatgt   1620

gagcagtcac tttatggtca catgcattct atcaatgatg ccatttttga tcccaggggt   1680

cacatgatag catcctgtga tgcctgtggg gttacaaagc tgtgggactt tcggaagctg   1740

ttaccaattg tgtccatcga tataggtcca agtcctggca atgaggtgaa ttttgattca   1800

tcaggtcgag ttttagctca ggcaagtggc aatggtgtta tccatttgct agatcttaaa   1860

tctggggaga ttcacaaatt gatgggccac gaaaacgagg cacacacggt tgtgttttct   1920

cacgacgggg agattctctt ttctggaggc tctgacggca cagttcgaac gtggtcttga   1980

ccgtcagcac atcccgctgc agagggcatt ccctttaagg cttgaaaatg cctcctgtag   2040

tcccaaacca gcaaagaact ggttaaatgt gccagcaggt aacatttaca gtctgcttta   2100

aaacatgctt tggacatata ttttagtgct catactgtta ctaataaaaa aataacttta   2160

tgctca                                                              2166


<210>  8914
<211>  631
<212>  PRT
<213>  Homosapiens

<400>  8914

Met Ala Ala Gln Arg Gly Met Pro Ser Ser Ala Val Arg Val Leu Glu 
1               5                   10                  15      


Glu Ala Leu Gly Met Gly Leu Thr Ala Ala Gly Asp Ala Arg Asp Thr 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Glu Gly Ala Tyr Tyr Leu Glu Gln Val Thr 
        35                  40                  45              


Ile Thr Glu Ala Ser Glu Asp Asp Tyr Glu Tyr Glu Glu Ile Pro Asp 
    50                  55                  60                  


Asp Asn Phe Ser Ile Pro Glu Gly Glu Glu Asp Leu Ala Lys Ala Ile 
65                  70                  75                  80  


Gln Met Ala Gln Glu Gln Ala Thr Asp Thr Glu Ile Leu Glu Arg Lys 
                85                  90                  95      


Thr Val Leu Pro Ser Lys His Ala Val Pro Glu Val Ile Glu Asp Phe 
            100                 105                 110         


Leu Cys Asn Phe Leu Ile Lys Met Gly Met Thr Arg Thr Leu Asp Cys 
        115                 120                 125             


Phe Gln Ser Glu Trp Tyr Glu Leu Ile Gln Lys Gly Val Thr Glu Leu 
    130                 135                 140                 


Arg Thr Val Gly Asn Val Pro Asp Val Tyr Thr Gln Ile Met Leu Leu 
145                 150                 155                 160 


Glu Asn Glu Asn Lys Asn Leu Lys Lys Asp Leu Lys His Tyr Lys Gln 
                165                 170                 175     


Ala Ala Asp Lys Ala Arg Glu Asp Leu Leu Lys Ile Gln Lys Glu Arg 
            180                 185                 190         


Asp Phe His Arg Met His His Lys Arg Ile Val Gln Glu Lys Asn Lys 
        195                 200                 205             


Leu Ile Asn Asp Leu Lys Gly Leu Lys Leu His Tyr Ala Ser Tyr Glu 
    210                 215                 220                 


Pro Thr Ile Arg Val Leu His Glu Lys His His Thr Leu Leu Lys Glu 
225                 230                 235                 240 


Lys Met Leu Thr Ser Leu Glu Arg Asp Lys Val Val Gly Gln Ile Ser 
                245                 250                 255     


Gly Leu Gln Glu Thr Leu Lys Lys Leu Gln Arg Gly His Ser Tyr His 
            260                 265                 270         


Gly Pro Gln Ile Lys Val Asp His Ser Arg Glu Lys Glu Asn Ala Pro 
        275                 280                 285             


Glu Gly Pro Thr Gln Lys Gly Leu Arg Glu Ala Arg Glu Gln Asn Lys 
    290                 295                 300                 


Cys Lys Thr Lys Met Lys Gly Asn Thr Lys Asp Ser Glu Phe Pro Ile 
305                 310                 315                 320 


Asp Met Gln Pro Asn Pro Asn Leu Asn Val Ser Lys Glu Ser Leu Ser 
                325                 330                 335     


Pro Ala Lys Phe Asp Tyr Lys Leu Lys Asn Ile Phe Arg Leu His Glu 
            340                 345                 350         


Leu Pro Val Ser Cys Val Ser Met Gln Pro His Lys Asp Ile Leu Val 
        355                 360                 365             


Ser Cys Gly Glu Asp Arg Leu Trp Lys Val Leu Gly Leu Pro Lys Cys 
    370                 375                 380                 


Asn Val Leu Leu Thr Gly Phe Gly His Thr Asp Trp Leu Ser Asp Cys 
385                 390                 395                 400 


Cys Phe His Pro Ser Gly Asp Lys Leu Ala Thr Ser Ser Gly Asp Thr 
                405                 410                 415     


Thr Val Lys Leu Trp Asp Leu Cys Lys Gly Asp Cys Ile Leu Thr Phe 
            420                 425                 430         


Glu Gly His Ser Arg Ala Val Trp Ser Cys Thr Trp His Ser Cys Gly 
        435                 440                 445             


Asn Phe Val Ala Ser Ser Ser Leu Asp Lys Thr Ser Lys Ile Trp Asp 
    450                 455                 460                 


Val Asn Ser Glu Arg Cys Arg Cys Thr Leu Tyr Gly His Thr Asp Ser 
465                 470                 475                 480 


Val Asn Ser Ile Glu Phe Phe Pro Phe Ser Asn Thr Leu Leu Thr Ser 
                485                 490                 495     


Ser Ala Asp Lys Thr Leu Ser Ile Trp Asp Ala Arg Thr Gly Ile Cys 
            500                 505                 510         


Glu Gln Ser Leu Tyr Gly His Met His Ser Ile Asn Asp Ala Ile Phe 
        515                 520                 525             


Asp Pro Arg Gly His Met Ile Ala Ser Cys Asp Ala Cys Gly Val Thr 
    530                 535                 540                 


Lys Leu Trp Asp Phe Arg Lys Leu Leu Pro Ile Val Ser Ile Asp Ile 
545                 550                 555                 560 


Gly Pro Ser Pro Gly Asn Glu Val Asn Phe Asp Ser Ser Gly Arg Val 
                565                 570                 575     


Leu Ala Gln Ala Ser Gly Asn Gly Val Ile His Leu Leu Asp Leu Lys 
            580                 585                 590         


Ser Gly Glu Ile His Lys Leu Met Gly His Glu Asn Glu Ala His Thr 
        595                 600                 605             


Val Val Phe Ser His Asp Gly Glu Ile Leu Phe Ser Gly Gly Ser Asp 
    610                 615                 620                 


Gly Thr Val Arg Thr Trp Ser 
625                 630     


<210>  8915
<211>  2363
<212>  DNA
<213>  Homosapiens

<400>  8915
agcgtcttcg ctgttgccct tagggacggc tgtgggcctg ctgggggtgg gggcccgaag     60

cgccagagat ggctgctcag cgagggatgc ccagctccgc cgtgagggtc ctggaagagg    120

cgttgggcat gggtttgacg gcagccgggg acgcgaggga cacggcggac gcggtggcgg    180

ctgagggcgc ctactacctg gaacgtatcc ttcccgtgga ggcgcggccc gctgcgctgg    240

cgggtaatgg gtgttgggac gaaggcgagg gcctcccact ggcggcgcct tttgagcctt    300

ggggccactc cggaggagcc tctgttggac ttcaagatac cagatgacaa ttttagcatc    360

ccagaaggtg aagaagatct ggcaaaagca attcagatgg cccaagaaca ggctacagat    420

actgaaattt tggaacggaa aacagttctt ccttcaaagc atgcagtacc tgaagtaata    480

gaagactttc tctgcaattt cttgatcaaa atgggaatga ccagaactct tgattgcttt    540

cagtctgaat ggtatgagtt aatacagaaa ggagtgactg aacttagaac tgttgggaat    600

gttccagatg tctacaccca gattatgctt ttggaaaatg agaacaaaaa tttaaagaaa    660

gatttgaagc actacaaaca agcagctgac aaagctagag aagatttgct gaaaattcag    720

aaagaacgtg attttcatcg aatgcatcat aagcgaatag tccaggaaaa aaacaaatta    780

attaatgacc tcaaagggtt gaagttacat tatgcatctt atgaaccgac tataagggtg    840

ttacatgaga aacaccacac tttactgaag gagaaaatgc tgacctcctt ggaaagagac    900

aaagtagttg ggcagatttc tggacttcaa gaaacattga agaaactgca aagaggacat    960

agttaccatg gtcctcaaat taaaggtaaa tgtaaaatgt gatgaagctc tcatttaata   1020

tagtttggtg atttctcaac cttatcagtg attaatattc tagagatatt taaaggtgag   1080

taagtggtgg ctatttcaca aattaaaatt ttaataaaaa gattaagaag aaatatagat   1140

atcatactgt atggattaat tatagagaaa aacaagtcaa ctataatgga aggacttctg   1200

cttctggtca ttatacctgg taccagacta gccttctctg tgtaaataac tctaaagcta   1260

agctgtaaga tcagacaact acttttaggc agtagaaaac agacagctca agtaacagaa   1320

ggcaattgac agaaggaaaa tttataaggt gagctctgcc atcaccatgg ctttgggtct   1380

gtggaaagtt ccaaactgag ctttgtggag atggaagcca ataagagcat gacaatcctg   1440

ataattggaa atgtcagaga ccctagttca cagcttttga agccactgga atctgtaggg   1500

aaagacacca gagaagagag ctgcaatgag gagtggctca gtttgtgagg gagtttacta   1560

tgagtcctta gctgaggctg caatactata cataacaaca ctacctgaca cttacaagag   1620

agatacaatt atataggatc aagaggaggc cagagattgt agaagttaag tagtgatgcg   1680

aaacattgca aatctggcca tgcctgggtg gaaagacctc tttcacacct tgttaacaac   1740

acagtaacat tcagcatccc atatccgcct tataaaacca ggaacaaagc ttacacagca   1800

ttcttagaga ggacacagaa tttggagttt gagtcttgcc aagttatagg gccttgagaa   1860

acatttaggg ctttccatgg atccacccta acgaagcata aaattaagcc taggatttta   1920

gggtcatcag ccaaaaatgg aactgccttc tagaacaaaa aatgacatcc ttttgaggaa   1980

gacagtcatc cagagtcttt acaatctttt acccacattg cctagtacat aattaaacat   2040

ttctagatat gaataggaac aggaaaatgt gacccataat caagacaaca agcaataaat   2100

ggaaacctac ccttaagtag ctaaactgtt gcatttagca gatagaaagt gctaaagtag   2160

atactttgat tatgttcaag gacttaatgg aaaatactaa taagtgaaca gatggggaat   2220

ttaagcaaag aaatgagaac aagcatacat tccaaagcaa aaaaaaaaaa aaaaaaagaa   2280

gaaagataaa agattaaagg aaaacttgcc tatttaacat atataaaatt aaagtcccaa   2340

agaagagaat gaaaatggag cat                                           2363


<210>  8916
<211>  251
<212>  PRT
<213>  Homosapiens

<400>  8916

Met Gly Val Gly Thr Lys Ala Arg Ala Ser His Trp Arg Arg Leu Leu 
1               5                   10                  15      


Ser Leu Gly Ala Thr Pro Glu Glu Pro Leu Leu Asp Phe Lys Ile Pro 
            20                  25                  30          


Asp Asp Asn Phe Ser Ile Pro Glu Gly Glu Glu Asp Leu Ala Lys Ala 
        35                  40                  45              


Ile Gln Met Ala Gln Glu Gln Ala Thr Asp Thr Glu Ile Leu Glu Arg 
    50                  55                  60                  


Lys Thr Val Leu Pro Ser Lys His Ala Val Pro Glu Val Ile Glu Asp 
65                  70                  75                  80  


Phe Leu Cys Asn Phe Leu Ile Lys Met Gly Met Thr Arg Thr Leu Asp 
                85                  90                  95      


Cys Phe Gln Ser Glu Trp Tyr Glu Leu Ile Gln Lys Gly Val Thr Glu 
            100                 105                 110         


Leu Arg Thr Val Gly Asn Val Pro Asp Val Tyr Thr Gln Ile Met Leu 
        115                 120                 125             


Leu Glu Asn Glu Asn Lys Asn Leu Lys Lys Asp Leu Lys His Tyr Lys 
    130                 135                 140                 


Gln Ala Ala Asp Lys Ala Arg Glu Asp Leu Leu Lys Ile Gln Lys Glu 
145                 150                 155                 160 


Arg Asp Phe His Arg Met His His Lys Arg Ile Val Gln Glu Lys Asn 
                165                 170                 175     


Lys Leu Ile Asn Asp Leu Lys Gly Leu Lys Leu His Tyr Ala Ser Tyr 
            180                 185                 190         


Glu Pro Thr Ile Arg Val Leu His Glu Lys His His Thr Leu Leu Lys 
        195                 200                 205             


Glu Lys Met Leu Thr Ser Leu Glu Arg Asp Lys Val Val Gly Gln Ile 
    210                 215                 220                 


Ser Gly Leu Gln Glu Thr Leu Lys Lys Leu Gln Arg Gly His Ser Tyr 
225                 230                 235                 240 


His Gly Pro Gln Ile Lys Gly Lys Cys Lys Met 
                245                 250     


<210>  8917
<211>  249
<212>  DNA
<213>  Homosapiens

<400>  8917
gttaatcttc agtaatttga attgtgctat gggctttctt ccgtaagacc ctgagcctta     60

atggattgaa ttgtcactcc ttgtttttgc ctcagatgtt ttcttgcctt gaatattggt    120

ttatctttct ttatctgttg tatttcctca tcgtctgtaa cgttcaacct aatagtctcc    180

ttaacatagc cttcattcac atatctaagg caagggaaat attcttctcc attgtgtatc    240

acttcacct                                                            249


<210>  8918
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  8918

Met Phe Ser Cys Leu Glu Tyr Trp Phe Ile Phe Leu Tyr Leu Leu Tyr 
1               5                   10                  15      


Phe Leu Ile Val Cys Asn Val Gln Pro Asn Ser Leu Leu Asn Ile Ala 
            20                  25                  30          


Phe Ile His Ile Ser Lys Ala Arg Glu Ile Phe Phe Ser Ile Val Tyr 
        35                  40                  45              


His Phe 
    50  


<210>  8919
<211>  759
<212>  DNA
<213>  Homosapiens

<400>  8919
ctttatgaac ttcctcacaa tgcccctgcc ttctactcta tcctcactgc ctgatcactc     60

cctagtctat tatgatattt ttccttcata gcagtcattt atctgctttc ctcaacaggt    120

tatgaataag attgccattt atttaaagta ggacttgaat agatatttgt tacttaaatc    180

caaagctatc ataatgccaa tctctttaac aggggcacag aaggcccttc ctttccattc    240

tatctttaaa cacattatca tttatcctat gccttaaaca gaatcgtgtt tatagtttgc    300

tgaatatgct atatgctctt tcatttttca tgaggatttc tgtttttttt ttttctttgc    360

atgcacagaa tttaaaaaaa atttaaaaaa aggaaaagtc acaaggtgga ttaggttgct    420

agaccttaaa acactccatg atttctttgt cttagtcatt tccttttttt aattgctaaa    480

ttttctttcc agattccctg cttttctttt agtaagagtt taactgtacc ttatacaaat    540

cagtaattat tctcttaata actagttata ctacagggtt agatagttgg ctcattcatt    600

aacaaagtta aacattttat tttaaaacaa gttttatttt gtaaatataa ccatttagca    660

ataacttaaa tttaagttta agccataaat ggaaaaatta ctacaacggt aaagcaacat    720

gtaagtcagt ctcaagagtg tttaaatttt atgcaatga                           759


<210>  8920
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  8920

Phe Ala Glu Tyr Ala Ile Cys Ser Phe Ile Phe His Glu Asp Phe Cys 
1               5                   10                  15      


Phe Phe Phe Phe Phe Ala Cys Thr Glu Phe Lys Lys Asn Leu Lys Lys 
            20                  25                  30          


Gly Lys Val Thr Arg Trp Ile Arg Leu Leu Asp Leu Lys Thr Leu His 
        35                  40                  45              


Asp Phe Phe Val Leu Val Ile Ser Phe Phe 
    50                  55              


<210>  8921
<211>  2181
<212>  DNA
<213>  Homosapiens

<400>  8921
ccgggcaggc ggcgggcggc gctcggagcg ggctccgcgg cttgcaaggc gcctgcgact     60

cggtcccagg tcggcgggcg gcgcacggcg ggctcgcgcg ggggccccgg cgcgccgggc    120

ggcgcagtac gcagcgcgcg gacccacgcc acggccagga gcccagagca gcgcggccac    180

actgcccagg ggtcggccct cggccccggc gctcggagcg cggcggctgc ctgggcttta    240

atggctgctc cgcggagcag cgcctagggc tggaaggcgg ctgcggctca ggaagtcacc    300

cgagcaagcc tccttcgggg ccggccgcac ccgccgcggc gcgctccatg ggggcgcgct    360

ccccccgggc ggcccgctga cccgggacgc cggggcccgc tcgctcgccg gccgcgcgtc    420

ccggccatga actgagcccg cgggccagcc ccgcgcctgc tccgcccgcg cctttcttct    480

cgcgcctcct ccgcccgccg ccggcgggcc cggctccccg ggggctgcgg cgccccgggc    540

tcggcggccc gcgggccccg gggcgcgggg cggcggcggc ggggggcgcg cggctccggg    600

cgcggcgcct gcaccatgaa ctaccagcag cagctggcca actcggctgc catccgggcc    660

gagatccagc gcttcgagtc ggtccacccc aacatctact ccatctacga gctgctggag    720

cgcgtggagg agccggtgct gcagaaccag atccgggagc acgtcatcgc catcgaagat    780

gccttcgtga acagccagga atggacgctg agtcgatctg tcccggagct caaagtggga    840

attgtgggta acttggccag cggcaagtct gccctggtgc accggtacct gacgggcaca    900

tatgtccagg aggagtctcc ggaaggtggc aggttcaaga aagagattgt cgttgatgga    960

cagagctatc tgctgctgat cagagatgaa gggggccccc cggaggcgca gtttgccatg   1020

tgggtggacg ctgttatatt tgtcttcagc ttggaggatg aaataagttt ccagaccgtt   1080

taccactact acagtcgaat ggccaactat cggaacacga gcgagattcc tctggttctg   1140

gtgggaaccc aggatgccat aagttctgct aacccgaggg tcatcgatga cgccagggcg   1200

aggaagctct ccaacgacct gaaacggtgc acgtactacg agacgtgtgc tacatacggg   1260

ctgaatgtgg agagggtctt ccaggacgtt gcccagaaga ttgttgccac aaggaagaag   1320

cagcagctgt ccataggacc ctgcaagtcg ctacctaatt ctcccagcca ttcctccgtc   1380

tgttccgcgc aggtgtctgc cgtgcacatc agccagacaa gtaatggagg tgggagttta   1440

agcgactatt cctcctccgt tccatcgact cccagcacca gccagaagga acttcggatc   1500

gatgttcctc ccactgccaa cacgcccacg cccgttcgca agcagtctaa gcgccggtcc   1560

aacctgttca cctctcggaa agggagcgac ccagacaaag agaagaaagg cctggagagt   1620

cgtgcggaca gcattgggag cggccgagcc atcccaatta aacagggcct gcccttcttt   1680

gtccttgcac tgacagccag cacttatctc aggcctgctg gagcccgtgc ccgtcagtcc   1740

tccccctggc cagggccgag gggtggtcag accagcccgc attgtgctga aggcccacaa   1800

tcagcccagc tgtccggggc catgatgaat tagcggtggg agttaacata gaggtgaact   1860

ccagatcggc cgatagcttg caggccgctg ctgtttgtcc tgacttcagc gcatctctga   1920

tagacctttg acaccttcca acaaagaggt tacaggaggg agagctggag aaatggagcg   1980

ctcctccaga aagttcggca actcacaaaa gaccccttaa tttctatagc gggcaattca   2040

gtccacaaag gaaggaaatc aatgagcgtt tacgctcttt ctttgaggaa ccttttttta   2100

aagaaaaaaa catttactgg cgctttgcat gttttgggta caagcagtgg tagaaacata   2160

aaacattaaa atccaagatt g                                             2181


<210>  8922
<211>  405
<212>  PRT
<213>  Homosapiens

<400>  8922

Met Asn Tyr Gln Gln Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu 
1               5                   10                  15      


Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu 
            20                  25                  30          


Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu 
        35                  40                  45              


His Val Ile Ala Ile Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Thr 
    50                  55                  60                  


Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Thr Gly Thr Tyr 
                85                  90                  95      


Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val 
            100                 105                 110         


Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Gln Phe Ala Met Trp Val Asp Ala Val Ile Phe Val Phe 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ile Ser Phe Gln Thr Val Tyr His Tyr Tyr Ser 
145                 150                 155                 160 


Arg Met Ala Asn Tyr Arg Asn Thr Ser Glu Ile Pro Leu Val Leu Val 
                165                 170                 175     


Gly Thr Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp 
            180                 185                 190         


Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Thr Tyr Tyr 
        195                 200                 205             


Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp 
    210                 215                 220                 


Val Ala Gln Lys Ile Val Ala Thr Arg Lys Lys Gln Gln Leu Ser Ile 
225                 230                 235                 240 


Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 
                245                 250                 255     


Ser Ala Gln Val Ser Ala Val His Ile Ser Gln Thr Ser Asn Gly Gly 
            260                 265                 270         


Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Thr Pro Ser Thr 
        275                 280                 285             


Ser Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Thr Ala Asn Thr Pro 
    290                 295                 300                 


Thr Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Thr Ser 
305                 310                 315                 320 


Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg 
                325                 330                 335     


Ala Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Leu 
            340                 345                 350         


Pro Phe Phe Val Leu Ala Leu Thr Ala Ser Thr Tyr Leu Arg Pro Ala 
        355                 360                 365             


Gly Ala Arg Ala Arg Gln Ser Ser Pro Trp Pro Gly Pro Arg Gly Gly 
    370                 375                 380                 


Gln Thr Ser Pro His Cys Ala Glu Gly Pro Gln Ser Ala Gln Leu Ser 
385                 390                 395                 400 


Gly Ala Met Met Asn 
                405 


<210>  8923
<211>  4163
<212>  DNA
<213>  Homosapiens

<400>  8923
ccgggcaggc ggcgggcggc gctcggagcg ggctccgcgg cttgcaaggc gcctgcgact     60

cggtcccagg tcggcgggcg gcgcacggcg ggctcgcgcg ggggccccgg cgcgccgggc    120

ggcgcagtac gcagcgcgcg gacccacgcc acggccagga gcccagagca gcgcggccac    180

actgcccagg ggtcggccct cggccccggc gctcggagcg cggcggctgc ctgggcttta    240

atggctgctc cgcggagcag cgcctagggc tggaaggcgg ctgcggctca ggaagtcacc    300

cgagcaagcc tccttcgggg ccggccgcac ccgccgcggc gcgctccatg ggggcgcgct    360

ccccccgggc ggcccgctga cccgggacgc cggggcccgc tcgctcgccg gccgcgcgtc    420

ccggccatga actgagcccg cgggccagcc ccgcgcctgc tccgcccgcg cctttcttct    480

cgcgcctcct ccgcccgccg ccggcgggcc cggctccccg ggggctgcgg cgccccgggc    540

tcggcggccc gcgggccccg gggcgcgggg cggcggcggc ggggggcgcg cggctccggg    600

cgcggcgcct gcaccatgaa ctaccagcag cagctggcca actcggctgc catccgggcc    660

gagatccagc gcttcgagtc ggtccacccc aacatctact ccatctacga gctgctggag    720

cgcgtggagg agccggtgct gcagaaccag atccgggagc acgtcatcgc catcgaagat    780

gccttcgtga acagccagga atggacgctg agtcgatctg tcccggagct caaagtggga    840

attgtgggta acttggccag cggcaagtct gccctggtgc accggtacct gacgggcaca    900

tatgtccagg aggagtctcc ggaaggtggc aggttcaaga aagagattgt cgttgatgga    960

cagagctatc tgctgctgat cagagatgaa gggggccccc cggaggcgca gtttgccatg   1020

tgggtggacg ctgttatatt tgtcttcagc ttggaggatg aaataagttt ccagaccgtt   1080

taccactact acagtcgaat ggccaactat cggaacacga gcgagattcc tctggttctg   1140

gtgggaaccc aggatgccat aagttctgct aacccgaggg tcatcgatga cgccagggcg   1200

aggaagctct ccaacgacct gaaacggtgc acgtactacg agacgtgtgc tacatacggg   1260

ctgaatgtgg agagggtctt ccaggacgtt gcccagaaga ttgttgccac aaggaagaag   1320

cagcagctgt ccataggacc ctgcaagtcg ctacctaatt ctcccagcca ttcctccgtc   1380

tgttccgcgc aggtgtctgc cgtgcacatc agccagacaa gtaatggagg tgggagttta   1440

agcgactatt cctcctccgt tccatcgact cccagcacca gccagaagga acttcggatc   1500

gatgttcctc ccactgccaa cacgcccacg cccgttcgca agcagtctaa gcgccggtcc   1560

aacctgttca cctctcggaa agggagcgac ccagacaaag agaagaaagg cctggagagt   1620

cgtgcggaca gcattgggag cggccgagcc atcccaatta aacagggcat gctgttgaag   1680

cgaagtggca aatcgttgaa taaagagtgg aaaaagaaat atgtcaccct gtgtgacaat   1740

ggcgtgctga cctatcatcc cagtttacat gattacatgc agaatgttca tggtaaggag   1800

attgaccttc tgagaaccac tgtgaaagtc ccagggaaga ggccaccccg agccacgtca   1860

gcctgcgcac ccatctccag ccctaaaacc aatggcctat ccaaggacat gagcagttta   1920

cacatctcac ccaattcaga cacagggctg ggtgactccg tatgctccag ccccagtatc   1980

tccagcacca ccagccccaa gctcgacccg cccccctccc ctcacgccaa cagaaagaag   2040

caccgaagga agaaaagcac tagcaacttc aaagccgacg gcctgtccgg cactgctgaa   2100

gaacaagaag aaaattttga gtttatcatt gtgtccctca ctggccaaac atggcacttt   2160

gaagccacga cgtatgagga gcgggacgcc tgggtccaag ccatcgagag ccagatcctg   2220

gccagcctgc agtcgtgcga gagcagcaag aacaagtccc ggctgacgag ccagagcgag   2280

gccatggccc tgcagtcgat ccggaacatg cgcgggaact cccactgtgt ggactgcgag   2340

acccagaatc ccaactgggc cagtttgaac ttgggagccc tcatgtgcat cgaatgctca   2400

gggatccacc ggaatcttgg cacccacctt tcccgagtcc gatctctgga cctggatgac   2460

tggccagtcg agctcatcaa ggtgatgtca tccatcggga acgagctagc caacagcgtc   2520

tgggaagaga gcagccaggg gcggacgaaa ccatcggtag actccacaag ggaagagaag   2580

gaacggtgga tccgtgccaa gtacgagcag aagctcttcc tggccccgct gccctgcacg   2640

gagctgtccc tgggccagca cctgctgcgg gccaccgccg acgaggacct gcggacggcc   2700

atcctgctgc tggcacacgg ctcccgggac gaggtgaacg agacctgcgg ggagggagac   2760

ggccgcacgg cgctgcatct ggcctgccgc aaggggaatg tggtcctggc gcagctcctg   2820

atctggtacg gagtggacgt cacggcccga gatgcccacg ggaacacagc tctggcctac   2880

gcccggcagg cctccagcca ggagtgcatc gacgtgctgc tgcagtacgg ctgccccgac   2940

gagcgcttcg tgctcatggc cacccctaac ctgtccagga gaaacaataa ccggaacaac   3000

agcagtggga gggtgcccac catcatctga ggaacagccg tgcccgcctg ctcgccgcac   3060

ctgggacgcg gcagcctcgc cgcattctcg ctcagaagtc gcagcacgtg agtcccgtcg   3120

catcccctcc ctcttcctgg tggccacctc cctcccgccc acccactctc accccaaaca   3180

aaatcacaaa acctggacat ccctcaaggg gcgaagaggc ggccgggaga ctgcagaagt   3240

ggctcctttt cataaactcc cctaaaccac acacaggaga gagcgacggg cctcggccct   3300

ttgatgatag cacatggcgc aggacccttg tcctggtggc acaagggatg gggacgcgag   3360

ggggagggga ggcgaggaac aaggagaagg ggcaactttc cttaactggc agttgagcac   3420

atagtacatt tcccctctac caaacggaac acttggattc catctcttct ctgaggagct   3480

cgacggcata aatcagaagc aagcacagag tttgtcaggt ttgaagcccc tatgatggtg   3540

tgtgtcaaat cagttgtagc taatctgtcc agggagaata ctggcttcat tacacttgta   3600

cagccgagtt cttcccgcat tactgctgtt taatagaacg tgattagtca tcgccgagaa   3660

gaaagcatat tagccgagga ggtagtcacg cggcacgcgc cggtgattgc cacgatgtga   3720

ttgcaatact cttagaagca ccatattatc ccagacatgt tctttcaagc ccttggagcc   3780

ctctctaaat tcactgtcat catttagtat ctgtttaatt tttcagtcca aagagaggaa   3840

atcagtcgct gagtattatt tgactccggt ctccttggtg caaaaacaaa atgggaaaaa   3900

taaataagaa taactcagaa actcaaaagg aaaccacaaa ttcagctaat aatagcattt   3960

cgagtatatt tcgtaaacta aggaaataca caaaaggctg ttttttccga ctgtaagaga   4020

tatttgatgt ccttttgccg aggtggatgt gttagtctca ggccctcctg gaccacgttg   4080

cccaagtcac acaggcttct gtgttatgta tttagataag atgtgtgaaa atatatttga   4140

ataaaagaag ttcataaata tgc                                           4163


<210>  8924
<211>  804
<212>  PRT
<213>  Homosapiens

<400>  8924

Met Asn Tyr Gln Gln Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu 
1               5                   10                  15      


Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu 
            20                  25                  30          


Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu 
        35                  40                  45              


His Val Ile Ala Ile Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Thr 
    50                  55                  60                  


Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Thr Gly Thr Tyr 
                85                  90                  95      


Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val 
            100                 105                 110         


Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Gln Phe Ala Met Trp Val Asp Ala Val Ile Phe Val Phe 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ile Ser Phe Gln Thr Val Tyr His Tyr Tyr Ser 
145                 150                 155                 160 


Arg Met Ala Asn Tyr Arg Asn Thr Ser Glu Ile Pro Leu Val Leu Val 
                165                 170                 175     


Gly Thr Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp 
            180                 185                 190         


Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Thr Tyr Tyr 
        195                 200                 205             


Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp 
    210                 215                 220                 


Val Ala Gln Lys Ile Val Ala Thr Arg Lys Lys Gln Gln Leu Ser Ile 
225                 230                 235                 240 


Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 
                245                 250                 255     


Ser Ala Gln Val Ser Ala Val His Ile Ser Gln Thr Ser Asn Gly Gly 
            260                 265                 270         


Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Thr Pro Ser Thr 
        275                 280                 285             


Ser Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Thr Ala Asn Thr Pro 
    290                 295                 300                 


Thr Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Thr Ser 
305                 310                 315                 320 


Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg 
                325                 330                 335     


Ala Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Met 
            340                 345                 350         


Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys 
        355                 360                 365             


Tyr Val Thr Leu Cys Asp Asn Gly Val Leu Thr Tyr His Pro Ser Leu 
    370                 375                 380                 


His Asp Tyr Met Gln Asn Val His Gly Lys Glu Ile Asp Leu Leu Arg 
385                 390                 395                 400 


Thr Thr Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Thr Ser Ala 
                405                 410                 415     


Cys Ala Pro Ile Ser Ser Pro Lys Thr Asn Gly Leu Ser Lys Asp Met 
            420                 425                 430         


Ser Ser Leu His Ile Ser Pro Asn Ser Asp Thr Gly Leu Gly Asp Ser 
        435                 440                 445             


Val Cys Ser Ser Pro Ser Ile Ser Ser Thr Thr Ser Pro Lys Leu Asp 
    450                 455                 460                 


Pro Pro Pro Ser Pro His Ala Asn Arg Lys Lys His Arg Arg Lys Lys 
465                 470                 475                 480 


Ser Thr Ser Asn Phe Lys Ala Asp Gly Leu Ser Gly Thr Ala Glu Glu 
                485                 490                 495     


Gln Glu Glu Asn Phe Glu Phe Ile Ile Val Ser Leu Thr Gly Gln Thr 
            500                 505                 510         


Trp His Phe Glu Ala Thr Thr Tyr Glu Glu Arg Asp Ala Trp Val Gln 
        515                 520                 525             


Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser 
    530                 535                 540                 


Lys Asn Lys Ser Arg Leu Thr Ser Gln Ser Glu Ala Met Ala Leu Gln 
545                 550                 555                 560 


Ser Ile Arg Asn Met Arg Gly Asn Ser His Cys Val Asp Cys Glu Thr 
                565                 570                 575     


Gln Asn Pro Asn Trp Ala Ser Leu Asn Leu Gly Ala Leu Met Cys Ile 
            580                 585                 590         


Glu Cys Ser Gly Ile His Arg Asn Leu Gly Thr His Leu Ser Arg Val 
        595                 600                 605             


Arg Ser Leu Asp Leu Asp Asp Trp Pro Val Glu Leu Ile Lys Val Met 
    610                 615                 620                 


Ser Ser Ile Gly Asn Glu Leu Ala Asn Ser Val Trp Glu Glu Ser Ser 
625                 630                 635                 640 


Gln Gly Arg Thr Lys Pro Ser Val Asp Ser Thr Arg Glu Glu Lys Glu 
                645                 650                 655     


Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu Phe Leu Ala Pro Leu 
            660                 665                 670         


Pro Cys Thr Glu Leu Ser Leu Gly Gln His Leu Leu Arg Ala Thr Ala 
        675                 680                 685             


Asp Glu Asp Leu Arg Thr Ala Ile Leu Leu Leu Ala His Gly Ser Arg 
    690                 695                 700                 


Asp Glu Val Asn Glu Thr Cys Gly Glu Gly Asp Gly Arg Thr Ala Leu 
705                 710                 715                 720 


His Leu Ala Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu Ile 
                725                 730                 735     


Trp Tyr Gly Val Asp Val Thr Ala Arg Asp Ala His Gly Asn Thr Ala 
            740                 745                 750         


Leu Ala Tyr Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asp Val Leu 
        755                 760                 765             


Leu Gln Tyr Gly Cys Pro Asp Glu Arg Phe Val Leu Met Ala Thr Pro 
    770                 775                 780                 


Asn Leu Ser Arg Arg Asn Asn Asn Arg Asn Asn Ser Ser Gly Arg Val 
785                 790                 795                 800 


Pro Thr Ile Ile 
                


<210>  8925
<211>  5674
<212>  DNA
<213>  Homosapiens

<400>  8925
ccgggcaggc ggcgggcggc gctcggagcg ggctccgcgg cttgcaaggc gcctgcgact     60

cggtcccagg tcggcgggcg gcgcacggcg ggctcgcgcg ggggccccgg cgcgccgggc    120

ggcgcagtac gcagcgcgcg gacccacgcc acggccagga gcccagagca gcgcggccac    180

actgcccagg ggtcggccct cggccccggc gctcggagcg cggcggctgc ctgggcttta    240

atggctgctc cgcggagcag cgcctagggc tggaaggcgg ctgcggctca ggaagtcacc    300

cgagcaagcc tccttcgggg ccggccgcac ccgccgcggc gcgctccatg ggggcgcgct    360

ccccccgggc ggcccgctga cccgggacgc cggggcccgc tcgctcgccg gccgcgcgtc    420

ccggccatga actgagcccg cgggccagcc ccgcgcctgc tccgcccgcg cctttcttct    480

cgcgcctcct ccgcccgccg ccggcgggcc cggctccccg ggggctgcgg cgccccgggc    540

tcggcggccc gcgggccccg gggcgcgggg cggcggcggc ggggggcgcg cggctccggg    600

cgcggcgcct gcaccatgaa ctaccagcag cagctggcca actcggctgc catccgggcc    660

gagatccagc gcttcgagtc ggtccacccc aacatctact ccatctacga gctgctggag    720

cgcgtggagg agccggtgct gcagaaccag atccgggagc acgtcatcgc catcgaagat    780

gccttcgtga acagccagga atggacgctg agtcgatctg tcccggagct caaagtggga    840

attgtgggta acttggccag cggcaagtct gccctggtgc accggtacct gacgggcaca    900

tatgtccagg aggagtctcc ggaaggtggc aggttcaaga aagagattgt cgttgatgga    960

cagagctatc tgctgctgat cagagatgaa gggggccccc cggaggcgca gtttgccatg   1020

tgggtggacg ctgttatatt tgtcttcagc ttggaggatg aaataagttt ccagaccgtt   1080

taccactact acagtcgaat ggccaactat cggaacacga gcgagattcc tctggttctg   1140

gtgggaaccc aggatgccat aagttctgct aacccgaggg tcatcgatga cgccagggcg   1200

aggaagctct ccaacgacct gaaacggtgc acgtactacg agacgtgtgc tacatacggg   1260

ctgaatgtgg agagggtctt ccaggacgtt gcccagaaga ttgttgccac aaggaagaag   1320

cagcagctgt ccataggacc ctgcaagtcg ctacctaatt ctcccagcca ttcctccgtc   1380

tgttccgcgc aggtgtctgc cgtgcacatc agccagacaa gtaatggagg tgggagttta   1440

agcgactatt cctcctccgt tccatcgact cccagcacca gccagaagga acttcggatc   1500

gatgttcctc ccactgccaa cacgcccacg cccgttcgca agcagtctaa gcgccggtcc   1560

aacctgttca cctctcggaa agggagcgac ccagacaaag agaagaaagg cctggagagt   1620

cgtgcggaca gcattgggag cggccgagcc atcccaatta aacagggcat gctgttgaag   1680

cgaagtggca aatcgttgaa taaagagtgg aaaaagaaat atgtcaccct gtgtgacaat   1740

ggcgtgctga cctatcatcc cagtttacat gattacatgc agaatgttca tggtaaggag   1800

attgaccttc tgagaaccac tgtgaaagtc ccagggaaga ggccaccccg agccacgtca   1860

gcctgcgcac ccatctccag ccctaaaacc aatggcctat ccaaggacat gagcagttta   1920

cacatctcac ccaattcaga cacagggctg ggtgactccg tatgctccag ccccagtatc   1980

tccagcacca ccagccccaa gctcgacccg cccccctccc ctcacgccaa cagaaagaag   2040

caccgaagga agaaaagcac tagcaacttc aaagccgacg gcctgtccgg cactgctgaa   2100

gaacaagaag aaaattttga gtttatcatt gtgtccctca ctggccaaac atggcacttt   2160

gaagccacga cgtatgagga gcgggacgcc tgggtccaag ccatcgagag ccagatcctg   2220

gccagcctgc agtcgtgcga gagcagcaag aacaagtccc ggctgacgag ccagagcgag   2280

gccatggccc tgcagtcgat ccggaacatg cgcgggaact cccactgtgt ggactgcgag   2340

acccagaatc ccaactgggc cagtttgaac ttgggagccc tcatgtgcat cgaatgctca   2400

gggatccacc ggaatcttgg cacccacctt tcccgagtcc gatctctgga cctggatgac   2460

tggccagtcg agctcatcaa ggtgatgtca tccatcggga acgagctagc caacagcgtc   2520

tgggaagaga gcagccaggg gcggacgaaa ccatcggtag actccacaag ggaagagaag   2580

gaacggtgga tccgtgccaa gtacgagcag aagctcttcc tggccccgct gccctgcacg   2640

gagctgtccc tgggccagca cctgctgcgg gccaccgccg acgaggacct gcggacggcc   2700

atcctgctgc tggcacacgg ctcccgggac gaggtgaacg agacctgcgg ggagggagac   2760

ggccgcacgg cgctgcatct ggcctgccgc aaggggaatg tggtcctggc gcagctcctg   2820

atctggtacg gagtggacgt cacggcccga gatgcccacg ggaacacagc tctggcctac   2880

gcccggcagg cctccagcca ggagtgcatc gacgtgctgc tgcagtacgg ctgccccgac   2940

gagcgcttcg tgctcatggc cacccctaac ctgtccagga gaaacaataa ccggaacaac   3000

agcagtggga gggtgcccac catcatctga ggaacagccg tgcccgcctg ctcgccgcac   3060

ctgggacgcg gcagcctcgc cgcattctcg ctcagaagtc gcagcacgtg agtcccgtcg   3120

catcccctcc ctcttcctgg tggccacctc cctcccgccc acccactctc accccaaaca   3180

aaatcacaaa acctggacat ccctcaaggg gcgaagaggc ggccgggaga ctgcagaagt   3240

ggctcctttt cataaactcc cctaaaccac acacaggaga gagcgacggg cctcggccct   3300

ttgatgatag cacatggcgc aggacccttg tcctggtggc acaagggatg gggacgcgag   3360

ggggagggga ggcgaggaac aaggagaagg ggcaactttc cttaactggc agttgagcac   3420

atagtacatt tcccctctac caaacggaac acttggattc catctcttct ctgaggagct   3480

cgacggcata aatcagaagc aagcacagag tttgtcaggt ttgaagcccc tatgatggtg   3540

tgtgtcaaat cagttgtagc taatctgtcc agggagaata ctggcttcat tacacttgta   3600

cagccgagtt cttcccgcat tactgctgtt taatagaacg tgattagtca tcgccgagaa   3660

gaaagcatat tagccgagga ggtagtcacg cggcacgcgc cggtgattgc cacgatgtga   3720

ttgcaatact cttagaagca ccatattatc ccagacatgt tctttcaagc ccttggagcc   3780

ctctctaaat tcactgtcat catttagtat ctgtttaatt tttcagtcca aagagaggaa   3840

atcagtcgct gagtattatt tgactccggt ctccttggtg caaaaacaaa atgggaaaaa   3900

taaataagaa taactcagaa actcaaaagg aaaccacaaa ttcagctaat aatagcattt   3960

cgagtatatt tcgtaaacta aggaaataca caaaaggctg ttttttccga ctgtaagaga   4020

tatttgatgt ccttttgccg aggtggatgt gttagtctca ggccctcctg gaccacgttg   4080

cccaagtcac acaggcttct gtgttatgta tttagataag atgtgtgaaa atatatttga   4140

ataaaagaag ttcataaata tgcattgatt tttgtacaga caaatggcac ctctcttaat   4200

ttataaattg aactggatgt gaactaataa tgtgcaacta gttgagataa gagggttaca   4260

gatcattgta catggaaaat attcccagca gtaaacactt ccattaatgt gatctacggc   4320

ttttgaaaag gagcatctca gaataagatg gtggtacaat ttgcttatta aaattgagaa   4380

agaaaaaaaa agacacactg gagtatatta gaaaggaaaa agaaggaatg tggtctctca   4440

tgattgaaag catgatttag atcggatacg gcttttgcta accaaggacc aagggactct   4500

ggcaagatgg ggtggttttc cgaatgccag accgaggtgc cttacgaagg cagctgccaa   4560

tggttctgtg gcacagactg gctcctgaga acccagacga ccttgacctg gcagcccggc   4620

cctccacgct agtacctcgc ctgattttcc atcgttgcgg tatccagccg cttcagacgt   4680

ccgccgcctt cagtggtggt agtcaaatgt agtcaaccaa accacagcat cccttaggtt   4740

aaaagcaaac ggggcagctt tgcctagagc tcattgacag tgtgatgggg ggagaagggt   4800

tgtcacaatg gaagatgagg acactagact catgtagcac agaaacatga agccacacgc   4860

accggcagcc tccggggtgt tcctcgctct ctcgtatgtt aaaccttata ttttataaga   4920

gtttttcctc ttatttcact ttttaaaaaa aattaaagta ggtggggaaa aaaataaagc   4980

tttacacaga atttatatgt gggtaagtgt ttcatggaaa tttctaatct taacgaagct   5040

aagtggagct cactcgtatc caaaagtata acaggtgcag aagccacaag tctgagaacc   5100

ttgacgacag ttccatcgtc ctgccatttg atttttcagt ctgcgtttca tcactgtgta   5160

gctattgtaa atgtgaatag aaaaaaacag gtcattgcct atttttgaag aacgcgttgg   5220

tgttcgagtc cactagacac actcgctcca cacagccttc accgtagact ctgtagtgga   5280

cacagatata gcataaatga aattgttaaa ttatttcatt gtagttaatt cccactatag   5340

gaatgcttta tcatagtgaa gtttcttttg agaagaaacg gaactccttg aggcttctct   5400

ttgggatgta tatgagcgtg tacatattat tctatgtgtt tataatataa tattttccca   5460

aatgacttct tgtttcactt tgccttccac aacctgaatg ccagattggt tttttccctt   5520

cctggccccc agcacaagct gccatgactc cccctcagaa aacacagccc ctcctctacc   5580

attctcagtg atgtccatct gctccactcc gcagccactt tctagggccc aagttttggt   5640

agcagaagga aaggcagttt ttgagggtct ttcg                               5674


<210>  8926
<211>  804
<212>  PRT
<213>  Homosapiens

<400>  8926

Met Asn Tyr Gln Gln Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu 
1               5                   10                  15      


Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu 
            20                  25                  30          


Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu 
        35                  40                  45              


His Val Ile Ala Ile Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Thr 
    50                  55                  60                  


Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Thr Gly Thr Tyr 
                85                  90                  95      


Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val 
            100                 105                 110         


Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Gln Phe Ala Met Trp Val Asp Ala Val Ile Phe Val Phe 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ile Ser Phe Gln Thr Val Tyr His Tyr Tyr Ser 
145                 150                 155                 160 


Arg Met Ala Asn Tyr Arg Asn Thr Ser Glu Ile Pro Leu Val Leu Val 
                165                 170                 175     


Gly Thr Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp 
            180                 185                 190         


Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Thr Tyr Tyr 
        195                 200                 205             


Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp 
    210                 215                 220                 


Val Ala Gln Lys Ile Val Ala Thr Arg Lys Lys Gln Gln Leu Ser Ile 
225                 230                 235                 240 


Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 
                245                 250                 255     


Ser Ala Gln Val Ser Ala Val His Ile Ser Gln Thr Ser Asn Gly Gly 
            260                 265                 270         


Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Thr Pro Ser Thr 
        275                 280                 285             


Ser Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Thr Ala Asn Thr Pro 
    290                 295                 300                 


Thr Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Thr Ser 
305                 310                 315                 320 


Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg 
                325                 330                 335     


Ala Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Met 
            340                 345                 350         


Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys 
        355                 360                 365             


Tyr Val Thr Leu Cys Asp Asn Gly Val Leu Thr Tyr His Pro Ser Leu 
    370                 375                 380                 


His Asp Tyr Met Gln Asn Val His Gly Lys Glu Ile Asp Leu Leu Arg 
385                 390                 395                 400 


Thr Thr Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Thr Ser Ala 
                405                 410                 415     


Cys Ala Pro Ile Ser Ser Pro Lys Thr Asn Gly Leu Ser Lys Asp Met 
            420                 425                 430         


Ser Ser Leu His Ile Ser Pro Asn Ser Asp Thr Gly Leu Gly Asp Ser 
        435                 440                 445             


Val Cys Ser Ser Pro Ser Ile Ser Ser Thr Thr Ser Pro Lys Leu Asp 
    450                 455                 460                 


Pro Pro Pro Ser Pro His Ala Asn Arg Lys Lys His Arg Arg Lys Lys 
465                 470                 475                 480 


Ser Thr Ser Asn Phe Lys Ala Asp Gly Leu Ser Gly Thr Ala Glu Glu 
                485                 490                 495     


Gln Glu Glu Asn Phe Glu Phe Ile Ile Val Ser Leu Thr Gly Gln Thr 
            500                 505                 510         


Trp His Phe Glu Ala Thr Thr Tyr Glu Glu Arg Asp Ala Trp Val Gln 
        515                 520                 525             


Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser 
    530                 535                 540                 


Lys Asn Lys Ser Arg Leu Thr Ser Gln Ser Glu Ala Met Ala Leu Gln 
545                 550                 555                 560 


Ser Ile Arg Asn Met Arg Gly Asn Ser His Cys Val Asp Cys Glu Thr 
                565                 570                 575     


Gln Asn Pro Asn Trp Ala Ser Leu Asn Leu Gly Ala Leu Met Cys Ile 
            580                 585                 590         


Glu Cys Ser Gly Ile His Arg Asn Leu Gly Thr His Leu Ser Arg Val 
        595                 600                 605             


Arg Ser Leu Asp Leu Asp Asp Trp Pro Val Glu Leu Ile Lys Val Met 
    610                 615                 620                 


Ser Ser Ile Gly Asn Glu Leu Ala Asn Ser Val Trp Glu Glu Ser Ser 
625                 630                 635                 640 


Gln Gly Arg Thr Lys Pro Ser Val Asp Ser Thr Arg Glu Glu Lys Glu 
                645                 650                 655     


Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu Phe Leu Ala Pro Leu 
            660                 665                 670         


Pro Cys Thr Glu Leu Ser Leu Gly Gln His Leu Leu Arg Ala Thr Ala 
        675                 680                 685             


Asp Glu Asp Leu Arg Thr Ala Ile Leu Leu Leu Ala His Gly Ser Arg 
    690                 695                 700                 


Asp Glu Val Asn Glu Thr Cys Gly Glu Gly Asp Gly Arg Thr Ala Leu 
705                 710                 715                 720 


His Leu Ala Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu Ile 
                725                 730                 735     


Trp Tyr Gly Val Asp Val Thr Ala Arg Asp Ala His Gly Asn Thr Ala 
            740                 745                 750         


Leu Ala Tyr Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asp Val Leu 
        755                 760                 765             


Leu Gln Tyr Gly Cys Pro Asp Glu Arg Phe Val Leu Met Ala Thr Pro 
    770                 775                 780                 


Asn Leu Ser Arg Arg Asn Asn Asn Arg Asn Asn Ser Ser Gly Arg Val 
785                 790                 795                 800 


Pro Thr Ile Ile 
                


<210>  8927
<211>  663
<212>  DNA
<213>  Homosapiens

<400>  8927
ctaggattgg agcatccaga acagagtcac ttcagcctgg gaagagcggg gacttgagct     60

tggagggagc tggagtggcc gcttgctgag tctttctccc tggagctcgt gggcagctgg    120

ttacctcgcg ctggggcgac cctgacttag gacctcctgc cgtttctctg ggtgactgct    180

ctgtagtcgt gagtcgtctc tttaatgctg agcatcagta cctgcacagc cctgaatgga    240

gcagctgccc agaatctgtc ttgtcatcga tagatggaca gttgccgagt gtcctgcgtg    300

ccgactgact aaggagtttt tgtctctgtc accctgtccc ctgtggtttt atgaagacgt    360

tagttatgaa tccgtgttta ggatgagaag atgtaaacag tgaggaggat aagtgagaag    420

ctagcaagag tctggatggt gatggcgggg gagcgctggt ggaggagtcg ggggcgtccc    480

gctggactgg ggcacagctc tgcagcagca gccggtgcgg ttttgccttg taagtgacac    540

cgttgcctgc aggcatctct gacagctgct cctgctccag attccagaaa tttctatgga    600

acatttcctg aaccatcctc ctggtttctt cccttcccct cactgaataa aatccgtaat    660

agc                                                                  663


<210>  8928
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  8928

Met Glu Gln Leu Pro Arg Ile Cys Leu Val Ile Asp Arg Trp Thr Val 
1               5                   10                  15      


Ala Glu Cys Pro Ala Cys Arg Leu Thr Lys Glu Phe Leu Ser Leu Ser 
            20                  25                  30          


Pro Cys Pro Leu Trp Phe Tyr Glu Asp Val Ser Tyr Glu Ser Val Phe 
        35                  40                  45              


Arg Met Arg Arg Cys Lys Gln 
    50                  55  


<210>  8929
<211>  1025
<212>  DNA
<213>  Homosapiens

<400>  8929
ctaggattgg agcatccaga acagagtcac ttcagcctgg gaagagcggg gacttgagct     60

tggagggagc tggagtggcc gcttgctgag tctttctccc tggagctcgt gggcagctgg    120

ttacctcgcg ctggggcgac cctgacttag gacctcctgc cgtttctctg ggtgactgct    180

ctgtagtcgt gagtcgtctc tttaatgctg agcatcagta cctgcacagc cctgaatgga    240

gcagctgccc agaatctgtc ttgtcatcga tagatggaca gttgccgagt gtcctgcgtg    300

ccgactgact aaggagtttt tgtctctgtc accctgtccc ctgtggtttt atgaagacgt    360

tagttatgaa tccgtgttta ggatgagaag atgtaaacag tgaggaggat aagtgagaag    420

ctagcaagag tctggatggt gatggcgggg gagcgctggt ggaggagtcg ggggcgtccc    480

gctggactgg ggcacagctc tgcagcagca gccggtgcgg ttttgccttg taagtgacac    540

cgttgcctgc aggcatctct gacagctgct cctgctccag attccagaaa tttctatgga    600

acatttcctg aaccatcctc ctggtttctt cccttcccct cactgaataa aatccgtaat    660

agcacctgcc gcttgagtgt ttgtctctgc aggacgccgt gttcagggct gggtgccctt    720

tgtgtcattt tgttatcctg gtcactgcca gacagaggtg gtaggaccct catttgtcag    780

gtcaggagcc tgcagcctgg agagtttaaa gccttgcctg aatccaccca cttctgaagg    840

tggcagagtc aggattcgaa ctcgggaccc gtggacacca gccacctatg ggcctttatt    900

tttatatttt taaaaacttt tagtttcagg ggtacacatg caggtgtgtt atataggtaa    960

gttgggtgtc atggtggtct ggtgtacaga ttattacaac gcatagtaag tacagtacct   1020

gatag                                                               1025


<210>  8930
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  8930

Met Glu Gln Leu Pro Arg Ile Cys Leu Val Ile Asp Arg Trp Thr Val 
1               5                   10                  15      


Ala Glu Cys Pro Ala Cys Arg Leu Thr Lys Glu Phe Leu Ser Leu Ser 
            20                  25                  30          


Pro Cys Pro Leu Trp Phe Tyr Glu Asp Val Ser Tyr Glu Ser Val Phe 
        35                  40                  45              


Arg Met Arg Arg Cys Lys Gln 
    50                  55  


<210>  8931
<211>  2745
<212>  DNA
<213>  Homosapiens

<400>  8931
aatgctgaaa gcttagtctt tggaatgtta tacattgttt ggatcttaaa aatgtcagct     60

cacaaaataa tgtttttaca tccttcctcc aacatcatca accgcattag ctcaccacca    120

ctcctcctct ccgcttctcc cccaacctgt tttatcggtg tcaggaaagg ggagcgatca    180

gtctctcagg aggtacccat attgatcata atatagcctt tcttaggcgt agcagtccag    240

caatcagggt tcaatggttt cctctggaag gtagcatact gaaaaagacg aagtgcagag    300

aaaagacagg gtgggggtgc agcatgtcta gtttgggggc ctggctgtgg gtcagaatgg    360

agagattgac acttcagaga aggccaggac gatggagaca agggaagtag aagttgaaag    420

aaactcccaa cggcaaatta ggtcgagtgc cagaaagaat tacatcagga gaatctgaga    480

tgtagtgaaa gtgcccccaa gctccccgct ccatttcatg tgctactggc tggctgtgag    540

atctgaaaag gactgggccc agactctgtg tgtgtgtgtg tgtgtgtgtg tgcgtgctct    600

taaatcaatg taaattaggc tatatacagc tgccaataat ctgcaaaaga tgacagtttc    660

atatgattcc aatggcttaa actaacaaat tcatgaatga ttgacccaga ccagaaatgg    720

aaacctgatt caactcacag tgtagtcctt tatccatgct tgttggcttc tggaacgcac    780

agtgttcagg aggattctga ggcagggtct gtgtgcagga ggagtgctag tgtgagagct    840

gctggtgcct gccctgggtc cgaaagctgg tggtggtctg ttcttgttgt atgagggcag    900

cccatgtcgc cagcatttat tttctgagcc ccatttctta atgttgtata tttttttaaa    960

aattaacacc accataagca agaaggaaaa aatcaacact tgctctttga aggccaaata   1020

cattgaaatg aaagcgtgcc tagtggagca agagcggggc ggggaggagg ggaagccagc   1080

ctgcagcatt gccctctaga cactaagaag aagggagtag gtttaggttg gatgaagaag   1140

ggaggtttgg agcctggacg agagcagggg ttgtggagga atggtcaaaa cccaggcgtg   1200

atgtgaccac accatctggc aggggaccag gccagctgct gtgtgggtct tccatgtccc   1260

agggacggag agaggagaag tggggttggc caggcagagg catgataaga gtcagagtgg   1320

ctgggctcca gggctccagc caggctatta gcaggagcac tggctttgga gggggaccta   1380

agaggacaga taggggaatc cccaggccac ctctggacct tgacattgac taatgggatg   1440

agctgctgga acccatcacc atgaagcccc ctgcactaac tagggcgtgt gccccttgag   1500

gagccgcatc cgcttattgg gcctaagaaa aactgattcc caggtgtgtt tgggccgtct   1560

agaaccatgt gacctggcag ccacttcaac ttgggcagca tctcggctgg gagccccagg   1620

gagcctggca gtacctcagt ggcagatgca gctcgttcca agatgttcca gaggcaggag   1680

gttcctggaa gaaccactgg gccttgcagg gtcagctcag cctgagagcc agtgaccccc   1740

tcccccagga ggatgctgta ggggcagtct cacggcggtc tcacctctgc cacctgtgga   1800

tgagaggctg gaccgggtct tggtgctttc cagctcaggg cgttggtcca cttggttatt   1860

cttggggacc aaaatccaag ctaggatggg gacagaggcc tggagacaac ctgctggcct   1920

ccttccatta aagccattac agtgtcacca caggattgta agaattacaa atgcgttttc   1980

cagagtcccc agagaaaaag gagtctggca gttagaagag taaagtgcat ctgtcaacaa   2040

aagaaatacc aaagatgaga ctacagcagc gacttgtcac ctcttccgtg ttgctactgc   2100

ctgagaacag aggtttttag tttctttaaa gggttgtaaa cataaaaaca aagaaggata   2160

caacatgcaa ggcctaaaat gtttactttc tggcctttta cacaggcagt tcgccagccc   2220

cctaccctac agtatggaaa aaaggcatag aacagtcaaa tcacgtagga tttcttagtt   2280

tctccatgca ggctcatcga atagcaacca tcctttctta gtttcttgaa acaagtacct   2340

tatttacatt cagagaatta tatgtggaca aacagctcat aagcccgtac ttttacatac   2400

tcacttcctg aattgcatat tgaaaaagag agttcatgta aagccgatta ttatttaatc   2460

taaagttatg ttcacatagg aagcactagt gtagagaaat agggtctgag ggacaaggag   2520

cctgtgtgcc cgtgtcggca gccgagtaac tgccaagggt cccctgcttg gcactctgct   2580

gtcccacttg cttcctgccc tctctggatt ctaacacttg tgccattgtg catccgtctc   2640

aggtcatggt gctgttactt ggtgagaaag cattatttaa ataccccaga tgaggagtta   2700

ggcactttct ccagttttgc aatgctcttt tgtttacctt ttaaa                   2745


<210>  8932
<211>  65
<212>  PRT
<213>  Homosapiens

<400>  8932

Met Ile Asp Pro Asp Gln Lys Trp Lys Pro Asp Ser Thr His Ser Val 
1               5                   10                  15      


Val Leu Tyr Pro Cys Leu Leu Ala Ser Gly Thr His Ser Val Gln Glu 
            20                  25                  30          


Asp Ser Glu Ala Gly Ser Val Cys Arg Arg Ser Ala Ser Val Arg Ala 
        35                  40                  45              


Ala Gly Ala Cys Pro Gly Ser Glu Ser Trp Trp Trp Ser Val Leu Val 
    50                  55                  60                  


Val 
65  


<210>  8933
<211>  443
<212>  DNA
<213>  Homosapiens

<400>  8933
aggggtatta atcaatgttt tgattaatta cacgtacata gaatttaaga caaagtaaag     60

gctcttccat ccccgcaagt ccccagagaa aatttataac agcaaagtat catcattact    120

aaattagagc gtgaccagcc tactggtctt gcccaagtcc acgctgactt gggaaaagtg    180

actgcctgcc gtgatggaag ggaagtactc aacccgacag actcagccct ttttaaaaac    240

tggaagcagg ggtgagtcat ggaactccct ctgcagcagc acctctatct tcccagccct    300

gggctggcga cagaggggga aaaaaagttg gctgaatgga ccagcaggtg agatgaagag    360

ttgattgtct tcaaacgtaa aatatctcaa gcaagaaaag aagaaaaaag tctcttcaat    420

aaatgttggc aatattttcg aga                                            443


<210>  8934
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  8934

Met Glu Gly Lys Tyr Ser Thr Arg Gln Thr Gln Pro Phe Leu Lys Thr 
1               5                   10                  15      


Gly Ser Arg Gly Glu Ser Trp Asn Ser Leu Cys Ser Ser Thr Ser Ile 
            20                  25                  30          


Phe Pro Ala Leu Gly Trp Arg Gln Arg Gly Lys Lys Ser Trp Leu Asn 
        35                  40                  45              


Gly Pro Ala Gly Glu Met Lys Ser 
    50                  55      


<210>  8935
<211>  289
<212>  DNA
<213>  Homosapiens

<400>  8935
gtccggccaa ggatgagcaa ggaacaaaga gcttttagaa cattaagcat acatctaaat     60

ttatttgacc tgaggatcca gcctggcctc tcaagagcag acgctcacat gataaaacgt    120

gctgggaact caccatgtac tcagcaaagg gaagcaaaga gggggaaaaa aagttggctg    180

aatggaccag caggtgagat gaagagttga ttgtcttcaa acgtaaaata tctcaagcaa    240

gaaaagaaga aaaaagtctc ttcaataaat gttggcaata ttttcgaga                289


<210>  8936
<211>  65
<212>  PRT
<213>  Homosapiens

<400>  8936

Met Ser Lys Glu Gln Arg Ala Phe Arg Thr Leu Ser Ile His Leu Asn 
1               5                   10                  15      


Leu Phe Asp Leu Arg Ile Gln Pro Gly Leu Ser Arg Ala Asp Ala His 
            20                  25                  30          


Met Ile Lys Arg Ala Gly Asn Ser Pro Cys Thr Gln Gln Arg Glu Ala 
        35                  40                  45              


Lys Arg Gly Lys Lys Ser Trp Leu Asn Gly Pro Ala Gly Glu Met Lys 
    50                  55                  60                  


Ser 
65  


<210>  8937
<211>  3700
<212>  DNA
<213>  Homosapiens

<400>  8937
gtcactgtct tgggctgtgt gctgacggga gccagggcct tgtaaggccc agaccctcct     60

ccttctctcc cgtattagtc aaggttctcc agagaaatgg agttagagat gcattgctat    120

aagaaatgga atgggctcgc atgattacag aggctgaggg gtcctacacc ctgtcgtctg    180

caagctggaa aggcaggaga gtctgtgctg cagccctagc cagagcctgg aggcccgaga    240

accaggcacg ccgacgacag cacacttcca gcctgagagc aagagaaggt cagtgttcca    300

gctccagcag gcaggcagag ggagggttct ctctccacct ttgtgttcta ctcaggtctt    360

caatgggttg gatgaggccc atccacattg cgagggcgtc tgcttcactg aatccaccat    420

cgtacctgct tctcttggat gccgtccgat tgcagagacg ctgttccctt gagggttcct    480

gccccaccgt gtgtgctggt gctaggatgt ctgccctggt ccagccctgc acccctgagt    540

cagaggctct tactctgggt tcaattaaga aggttatttg gcccccacac aaagctaaga    600

ctttcacctt ggcatttgtt aggaattctt tcctgaagtt ggacagtttg gccatgttca    660

agcctctgaa ttcttccata gaattgtctt ctggaaatca tgccacagta atttaagtct    720

ccccggctgt atgtgtgagg acttcttacc ctcttgggca tggaggggtt agcatgtttg    780

gtagccattc tagtcatagt aggttgacag ttgagtgttt cctagatctt tccaagtaga    840

ccagcatgac tatggaagag gccctgaagg tcccaccccg acacgccagt ccgaagggcc    900

cttgcctggg caccctgcac cttcccctgg acctgctgat gcgcctggct gggggaatgc    960

gggccttcgc gttggttcca cctccagctt ccatgactgt ggagttctgc agtgggttca   1020

ttgagaaagt ggtggtgaga ccagggtatc tgagaggagt ggtcggcagg gagatgagac   1080

aagtgtggag accaggcaga tggaaggcgc atgtctggag ggtgtgagag ctgccaggtg   1140

ggtgtctgca gggtcttgca gagtcgctca gccgcaggtg gggcggctct ggagacccta   1200

tcagcacatt ccagagagtg gcagacccca cggccaggca tggactgatg agcaggactg   1260

tcctccactg tccagacaac agcacagatg aaacccagga gcgcctggga cggtgctgtg   1320

agccctgcac atccacggag tctctcagat gaaaccacac gggtgtcaca gtgacgctct   1380

ctcccctcag aggctgccga cccctcgctg ggctgctgga ctgctcaggg ccggcccttg   1440

aagcctggag ggagccatgg gtctgtgtgt acacatgtgt gtgcccgtga gtgagtctat   1500

gtgtgatctc tgaaaatgaa gcttccacat taccaatgcc tggagaatcc agaactggga   1560

ctcccaggta actgagggcc tgggtcccaa agctggtggc tgaagctggc tgctccgagg   1620

catgcgtggc aggaaggggt catcaggagg gccacccaag gccccgggca cctctgatgg   1680

gtttccagag tccctgccct cacgagaggg aagtcagttg gagaatgggg tgctgaagtc   1740

tcgagagaaa ggtgtccttg actcggggtc cagagtaagc agcttctgcc ccccatatca   1800

cgtggctagt ggcttgtcct gactgtgccc cacgtgtcat ggcaaagttt cgacacccac   1860

tttggagatg tcttgacaga ggccagcgtc aggctcccgt tcttccacac gctggaagct   1920

gctgcacagc gggctcagag cctgggctca ggaggcatcc cggttactgt tgctgtatcc   1980

tggagggtgg catctcctgg gagctgtggt ccgagcccct tgcaacagcg gggccaggag   2040

aaggctggtt gctgggtgca tcctgttctt ggggttccac ctgctgtatc catctcccgg   2100

gggattttcc gtcgccgtcc ttggttccag cacatgccct gagtggtaat gccgattcct   2160

gcctgtgctg ccgacttggt gcggggagcc tgtggctgct ctgtcaggtg gttggccccg   2220

atggctccat gggtggcccc cgcccaggca tctcatggag ggactctgcc tacgtcactg   2280

gccgccagtc ctgggggaca ccgtgtgcat ttgcacatga accatgatgg gaacctgggg   2340

gacgggtctc aggctgagaa aggttcccct gggcttcaag gtaaatcata aagcgaggta   2400

atttcctata agtgtcagag gacactgtaa ctgtcccttc tgagcaggac attgttgtgg   2460

ttgtctgtct tcccttttgt cttctgcctg tgggattatc tagattctga gcaggtaaat   2520

tgtttcaggc tctggccttc tcagagcctt tctgtggctg taggttgtgg ggagggcacc   2580

atggtagttg cccctgcttc attcactcag agccactgac aggggccccc caacctgctc   2640

ggagccctcc aggggcaggc actgtccctg ctgcccccct gctgccctga acatctcccc   2700

agccccacag ctgacccacc ctttcagggt aacagtgcag ctgcgggggc agccccctcc   2760

agcccttcct tggtcagcct ccctgctgct ggcccttcct ggagacgtga tttgccctag   2820

aagtggcagg tgtgtgtggc tcatgccctc actgtaaggc tgtgccaagg cagtgccacc   2880

ttgggaaaaa tcaaaacccc ataccagctc ctcccagtcc atgccagcac acaccctggc   2940

tcctcagaac cccccacaga agcaggcaag gaatcaaaaa ctcaagtctg caggaagcca   3000

ggcagggatg gaggaggggt atactgtcac aggtgagagg gtcccagaag cctttctgga   3060

ggaggtgact tcaggctgga tttggagggg caacttaaca agcagacagg tgggtggaga   3120

cgctccagca gaggaaatgg catggagtgt ccaggagccc acgaatcagc tggcattgtt   3180

gaatcatgga gaacgcagag acggtctcag aagtcggccg gagcctgagt cattgggcca   3240

cgcggcttca gtccttcctt gcagcctgtg gggagtctca ggggaattct gaggaggaaa   3300

gggggatgct catgataggt atttattgtt tttgtttgtt tgtttttaat cacttatttt   3360

cacaagtgta atcgaagcac ctggttgtga gtccaggaga gtaaaacatt tagccctcgc   3420

ccctcccatc catcacggat tttctgacgc ctgcagcagg gttcctgcca aaggaaaacc   3480

catttatagt catatacttc cgtgaacctt tgatataacc cagttatgta tctagaaacc   3540

tgccttttca aaaatattaa cctgtctata aatgtagtaa atgttatata aaatgcaatc   3600

atgtttaaga agttaactat tgttatatta attcgagttg aacaattcaa attctcaact   3660

tcatttataa acatagttaa ttaaattcct ttatgcatat                         3700


<210>  8938
<211>  196
<212>  PRT
<213>  Homosapiens

<400>  8938

Met Glu Trp Ala Arg Met Ile Thr Glu Ala Glu Gly Ser Tyr Thr Leu 
1               5                   10                  15      


Ser Ser Ala Ser Trp Lys Gly Arg Arg Val Cys Ala Ala Ala Leu Ala 
            20                  25                  30          


Arg Ala Trp Arg Pro Glu Asn Gln Ala Arg Arg Arg Gln His Thr Ser 
        35                  40                  45              


Ser Leu Arg Ala Arg Glu Gly Gln Cys Ser Ser Ser Ser Arg Gln Ala 
    50                  55                  60                  


Glu Gly Gly Phe Ser Leu His Leu Cys Val Leu Leu Arg Ser Ser Met 
65                  70                  75                  80  


Gly Trp Met Arg Pro Ile His Ile Ala Arg Ala Ser Ala Ser Leu Asn 
                85                  90                  95      


Pro Pro Ser Tyr Leu Leu Leu Leu Asp Ala Val Arg Leu Gln Arg Arg 
            100                 105                 110         


Cys Ser Leu Glu Gly Ser Cys Pro Thr Val Cys Ala Gly Ala Arg Met 
        115                 120                 125             


Ser Ala Leu Val Gln Pro Cys Thr Pro Glu Ser Glu Ala Leu Thr Leu 
    130                 135                 140                 


Gly Ser Ile Lys Lys Val Ile Trp Pro Pro His Lys Ala Lys Thr Phe 
145                 150                 155                 160 


Thr Leu Ala Phe Val Arg Asn Ser Phe Leu Lys Leu Asp Ser Leu Ala 
                165                 170                 175     


Met Phe Lys Pro Leu Asn Ser Ser Ile Glu Leu Ser Ser Gly Asn His 
            180                 185                 190         


Ala Thr Val Ile 
        195     


<210>  8939
<211>  323
<212>  DNA
<213>  Homosapiens

<400>  8939
gagcttcctg agaggctgaa ggacacttta gaaatgtcag caggagagac ccacttccct     60

tttaacccat ggagtcagga ggagaggaaa gaaaagaggt tcacctcagg ctgctcagaa    120

ggaaggtgtt ccaggaaggc cagaaaaggg aggctgctct ggaaaaacaa agaagagctt    180

ggcaggtcct agaacggagg agaagttaga ccctgggaat ccaagatgct gcaacgtcag    240

gcagctggtc cccagcaagg ctggcacgtg gaaacctcac ggagaaaagt gattcataac    300

caaagcaggg ctcccacagc gac                                            323


<210>  8940
<211>  52
<212>  PRT
<213>  Homosapiens

<400>  8940

Met Ser Ala Gly Glu Thr His Phe Pro Phe Asn Pro Trp Ser Gln Glu 
1               5                   10                  15      


Glu Arg Lys Glu Lys Arg Phe Thr Ser Gly Cys Ser Glu Gly Arg Cys 
            20                  25                  30          


Ser Arg Lys Ala Arg Lys Gly Arg Leu Leu Trp Lys Asn Lys Glu Glu 
        35                  40                  45              


Leu Gly Arg Ser 
    50          


<210>  8941
<211>  2487
<212>  DNA
<213>  Homosapiens

<400>  8941
agtacccacg gaaaacttgt ttaccttgtc accatgagta aaagttaatt cccactcctg     60

aagagagcaa accaactctg aaagagagtg aaaatgcaga caagacagtt atcagataat    120

ggctatctgg acgagagatt ctttcgtttg acagcagttt ggttgttggg agttccagtt    180

cagctcctgc acagttgctc tgtacaaatc ctcctccata tttgcttaga gaaaacgtgt    240

tgccatccca tcatgaagga agctgcctga gagtttttaa ccattacagc cgtgatgatg    300

aaagagtgaa gaaccgcctc taagttaaaa agtgcaccca gagataaggt tcgttctcaa    360

tgccctgccg ctgcttctca tcgcatggcc accgcatttc tcaggccagg cacattgagc    420

attggtcctg tgcctgacgc tatgctagat gctggggttg cagccacgag catagacacg    480

acagacacgg tcctcgccat cttctgttga gtactggtcg gaacaagagg atcgtctgta    540

gacaggatat gatcatcgtg gcgcatgtat tactcatcct tttgggggcc actgagatac    600

tgcaagctga cttacttcct gatgaaaaga tttcacttct cccacctgtc aatttcacca    660

ttaaagttac tggtttggct caagttcttt tacaatggaa accaaatcct gatcaagagc    720

aaaggaatgt taatctagaa tatcaagtga aaataaacgc tccaaaagaa gatgactatg    780

aaaccagaat cactgaaagc aaatgtgtaa ccatcctcca caaaggcttt tcagcaagtg    840

tgcggaccat cctgcagaac gaccactcac tactggccag cagctgggct tctgctgaac    900

ttcatgcccc accagggtct cctggaacct caattgtgaa tttaacttgc accacaaaca    960

ctacagaaga caattattca cgtttaaggt cataccaagt ttcccttcac tgcacctggc   1020

ttgttggcac agatgcccct gaggacacgc agtattttct ctactatagg tatggctctt   1080

ggactgaaga atgccaagaa tacagcaaag acacactggg gagaaatatc gcatgctggt   1140

ttcccaggac ttttatcctc agcaaagggc gtgactggct tgcggtgctt gttaacggct   1200

ccagcaagca ctctgctatc aggccctttg atcagctgtt tgcccttcac gccattgatc   1260

aaataaatcc tccactgaat gtcacagcag agattgaagg aactcgtctc tctatccaat   1320

gggagaaacc agtgtctgct tttccaatcc attgctttga ttatgaagta aaaatacaca   1380

atacaaggaa tggatatttg cagatagaaa aattgatgac caatgcattc atctcaataa   1440

ttgatgatct ttctaagtac gatgttcaag tgagagcagc agtgagctcc atgtgcagag   1500

aggcagggct ctggagtgag tggagccaac ctatttatgt gggaaatgat gaacacaagc   1560

ccttgagaga gtggtttgtc attgtgatta tggcaaccat ctgcttcatc ttgttaattc   1620

tctcgcttat ctgtaaaata tgtcatttat ggatcaagtt gtttccacca attccagcac   1680

caaaaagtaa tatcaaagat ctctttgtaa ccactaacta tgagaaagct gggtccagtg   1740

agacggaaat tgaagtcatc tgttatatag agaagcctgg agttgagacc ctggaggatt   1800

ctgtgttttg actgtcactt tggcatcctc tgatgaactc acacatgcct cagtgcctca   1860

gtgaaaagaa cagggatgct ggctcttggc taagaggtgt tcagaattta ggcaacactc   1920

aatttacctg cgaagcaata cacccagaca caccagtctt gtatctctta aaagtatgga   1980

tgcttcatcc aaatcgcctc acctacagca gggaagttga ctcatccaag cattttgcca   2040

tgttttttct ccccatgccg tacagggtag cacctcctca cctgccaatc tttgcaattt   2100

gcttgactca cctcagactt ttcattcaca acagacagct tttaaggcta acgtccagct   2160

gtatttactt ctggctgtgc ccgtttggct gtttaagctg ccaattgtag cactcagcta   2220

ccatctgagg aagaaagcat tttgcatcag cctggagtga accatgaact tggattcaag   2280

actgtctttt ctatagcaag tgagagccac aaattcctca cccccctaca ttctagaatg   2340

atctttttct aggtagattg tgtatgtgtg tgtatgagag agagagagag agagagagag   2400

agagaaatta tctcaagctc cagaggcctg atccaggata catcatttga aaccaactaa   2460

tttaaaagca taatagagct aatatat                                       2487


<210>  8942
<211>  420
<212>  PRT
<213>  Homosapiens

<400>  8942

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  8943
<211>  2368
<212>  DNA
<213>  Homosapiens

<400>  8943
agtacccacg gaaaacttgt ttaccttgtc accatgagta aaagttaatt cccactcctg     60

aagagagcaa accaactctg aaagagagtg aaaatgcaga caagacagtt atcagataat    120

ggctatctgg acgagagatt ctttcgtttg acagcagttt ggttgttggg agttccagtt    180

cagctcctgc acagttgctc tgtacaaatc ctcctccata tttgcttaga gaaaacgtgt    240

tgccatccca tcatgaagga agctgcctga gagtttttaa ccattacagc cgtgatgatg    300

aaagagtgaa gaaccgcctc taagttaaaa agtgcaccca gagataaggt tcgttctcaa    360

tgccctgccg ctgcttctca tcgcatggcc accgcatttc tcaggccagg cacattgagc    420

attggtcctg tgcctgacgc tatgctagat gctggggttg cagccacgag catagacacg    480

acagacacgg tcctcgccat cttctgttga gtactggtcg gaacaagagg atcgtctgta    540

gacaggctac agattgtttt agattgaagt ttcctgtcat gttcactcat ctttaaatcc    600

tcatagtgaa aaaggatatg atcatcgtgg cgcatgtatt actcatcctt ttgggggcca    660

ctgagatact gcaagctgac ttacttcctg atgaaaagat ttcacttctc ccacctgtca    720

atttcaccat taaagttact ggtttggctc aagttctttt acaatggaaa ccaaatcctg    780

atcaagagca aaggaatgtt aatctagaat atcaagtgaa aataaacgct ccaaaagaag    840

atgactatga aaccagaatc actgaaagca aatgtgtaac catcctccac aaaggctttt    900

cagcaagtgt gcggaccatc ctgcagaacg accactcact actggccagc agctgggctt    960

ctgctgaact tcatgcccca ccagggtctc ctggaacctc aattgtgaat ttaacttgca   1020

ccacaaacac tacagaagac aattattcac gtttaaggtc ataccaagtt tcccttcact   1080

gcacctggct tgttggcaca gatgcccctg aggacacgca gtattttctc tactataggt   1140

atggctcttg gactgaagaa tgccaagaat acagcaaaga cacactgggg agaaatatcg   1200

catgctggtt tcccaggact tttatcctca gcaaagggcg tgactggctt gcggtgcttg   1260

ttaacggctc cagcaagcac tctgctatca ggccctttga tcagctgttt gcccttcacg   1320

ccattgatca aataaatcct ccactgaatg tcacagcaga gattgaagga actcgtctct   1380

ctatccaatg ggagaaacca gtgtctgctt ttccaatcca ttgctttgat tatgaagtaa   1440

aaatacacaa tacaaggaat ggatatttgc agatagaaaa attgatgacc aatgcattca   1500

tctcaataat tgatgatctt tctaagtacg atgttcaagt gagagcagca gtgagctcca   1560

tgtgcagaga ggcagggctc tggagtgagt ggagccaacc tatttatgtg ggaaatgatg   1620

aacacaagcc cttgagagag tggtttgtca ttgtgattat ggcaaccatc tgcttcatct   1680

tgttaattct ctcgcttatc tgtaaaatat gtcatttatg gatcaagttg tttccaccaa   1740

ttccagcacc aaaaagtaat atcaaagatc tctttgtaac cactaactat gagaaagctg   1800

ggtccagtga gacggaaatt gaagtcatct gttatataga gaagcctgga gttgagaccc   1860

tggaggattc tgtgttttga ctgtcacttt ggcatcctct gatgaactca cacatgcctc   1920

agtgcctcag tgaaaagaac agggatgctg gctcttggct aagaggtgtt cagaatttag   1980

gcaacactca atttacctgc gaagcaatac acccagacac accagtcttg tatctcttaa   2040

aagtatggat gcttcatcca aatcgcctca cctacagcag ggaagttgac tcatccaagc   2100

attttgccat gttttttctc cccatgccgt acagggtagc acctcctcac ctgccaatct   2160

ttgcaatttg cttgactcac ctcagacttt tcattcacaa cagacagctt ttaaggctaa   2220

cgtccagctg tatttacttc tggctgtgcc cgtttggctg tttaagctgc caattgtagc   2280

actcagctac catctgagga agaaagcatt ttgcatcagc ctggagtgaa ccatgaactt   2340

ggattcaaga ctgtcttttc tatagcaa                                      2368


<210>  8944
<211>  420
<212>  PRT
<213>  Homosapiens

<400>  8944

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  8945
<211>  1695
<212>  DNA
<213>  Homosapiens

<400>  8945
agtacccacg gaaaacttgt ttaccttgtc accatgagta aaagttaatt cccactcctg     60

aagagagcaa accaactctg aaagagagtg aaaatgcaga caagacagtt atcagataat    120

ggctatctgg acgagagatt ctttcgtttg acagcagttt ggttgttggg agttccagtt    180

cagctcctgc acagttgctc tgtacaaatc ctcctccata tttgcttaga gaaaacgtgt    240

tgccatccca tcatgaagga agctgcctga gagtttttaa ccattacagc cgtgatgatg    300

aaagagtgaa gaaccgcctc taagttaaaa agtgcaccca gagataaggt tcgttctcaa    360

tgccctgccg ctgcttctca tcgcatggcc accgcatttc tcaggccagg cacattgagc    420

attggtcctg tgcctgacgc tatgctagat gctggggttg cagccacgag catagacacg    480

acagacacgg tcctcgccat cttctgttga gtactggtcg gaacaagagg atcgtctgta    540

gacaggctac agattgtttt agattgaagt ttcctgtcat gttcactcat ctttaaatcc    600

tcatagtgaa aaaggatatg atcatcgtgg cgcatgtatt actcatcctt ttgggggcca    660

ctgagatact gcaagctgac ttacttcctg atgaaaagat ttcacttctc ccacctgtca    720

atttcaccat taaagttact ggtttggctc aagttctttt acaatggaaa ccaaatcctg    780

atcaagagca aaggaatgtt aatctagaat atcaagtgaa aataaacgct ccaaaagaag    840

atgactatga aaccagaatc actgaaagca aatgtgtaac catcctccac aaaggctttt    900

cagcaagtgt gcggaccatc ctgcagaacg accactcact actggccagc agctgggctt    960

ctgctgaact tcatgcccca ccagggtctc ctggaacctc aattgtgaat ttaacttgca   1020

ccacaaacac tacagaagac aattattcac gtttaaggtc ataccaagtt tcccttcact   1080

gcacctggct tgttggcaca gatgcccctg aggacacgca gtattttctc tactataggt   1140

atggctcttg gactgaagaa tgccaagaat acagcaaaga cacactgggg agaaatatcg   1200

catgctggtt tcccaggact tttatcctca gcaaagggcg tgactggctt gcggtgcttg   1260

ttaacggctc cagcaagcac tctgctatca ggccctttga tcagctgttt gcccttcacg   1320

ccattgatca aataaatcct ccactgaatg tcacagcaga gattgaagga actcgtctct   1380

ctatccaatg ggagaaacca gtgtctgctt ttccaatcca ttgctttgat tatgaagtaa   1440

aaatacacaa tacaaggaat ggatatttgc agatagaaaa attgatgacc aatgcattca   1500

tctcaataat tgatgatctt tctaagtacg atgttcaagt gagagcagca gtgagctcca   1560

tgtgcagaga ggcagggctc tggagtgagt ggagccaacc tatttatgtg gggttctcaa   1620

gataaaggag ataacatcca gctttcctgc cccacaccgt atctgaaata aaaacaacag   1680

cagggatagc agatt                                                    1695


<210>  8946
<211>  335
<212>  PRT
<213>  Homosapiens

<400>  8946

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Phe Ser Arg 
                325                 330                 335 


<210>  8947
<211>  1626
<212>  DNA
<213>  Homosapiens

<400>  8947
agtacccacg gaaaacttgt ttaccttgtc accatgagta aaagttaatt cccactcctg     60

aagagagcaa accaactctg aaagagagtg aaaatgcaga caagacagtt atcagataat    120

ggctatctgg acgagagatt ctttcgtttg acagcagttt ggttgttggg agttccagtt    180

cagctcctgc acagttgctc tgtacaaatc ctcctccata tttgcttaga gaaaacgtgt    240

tgccatccca tcatgaagga agctgcctga gagtttttaa ccattacagc cgtgatgatg    300

aaagagtgaa gaaccgcctc taagttaaaa agtgcaccca gagataaggt tcgttctcaa    360

tgccctgccg ctgcttctca tcgcatggcc accgcatttc tcaggccagg cacattgagc    420

attggtcctg tgcctgacgc tatgctagat gctggggttg cagccacgag catagacacg    480

acagacacgg tcctcgccat cttctgttga gtactggtcg gaacaagagg atcgtctgta    540

gacaggatat gatcatcgtg gcgcatgtat tactcatcct tttgggggcc actgagatac    600

tgcaagctga cttacttcct gatgaaaaga tttcacttct cccacctgtc aatttcacca    660

ttaaagttac tggtttggct caagttcttt tacaatggaa accaaatcct gatcaagagc    720

aaaggaatgt taatctagaa tatcaagtga aaataaacgc tccaaaagaa gatgactatg    780

aaaccagaat cactgaaagc aaatgtgtaa ccatcctcca caaaggcttt tcagcaagtg    840

tgcggaccat cctgcagaac gaccactcac tactggccag cagctgggct tctgctgaac    900

ttcatgcccc accagggtct cctggaacct caattgtgaa tttaacttgc accacaaaca    960

ctacagaaga caattattca cgtttaaggt cataccaagt ttcccttcac tgcacctggc   1020

ttgttggcac agatgcccct gaggacacgc agtattttct ctactatagg tatggctctt   1080

ggactgaaga atgccaagaa tacagcaaag acacactggg gagaaatatc gcatgctggt   1140

ttcccaggac ttttatcctc agcaaagggc gtgactggct tgcggtgctt gttaacggct   1200

ccagcaagca ctctgctatc aggccctttg atcagctgtt tgcccttcac gccattgatc   1260

aaataaatcc tccactgaat gtcacagcag agattgaagg aactcgtctc tctatccaat   1320

gggagaaacc agtgtctgct tttccaatcc attgctttga ttatgaagta aaaatacaca   1380

atacaaggaa tggatatttg cagatagaaa aattgatgac caatgcattc atctcaataa   1440

ttgatgatct ttctaagtac gatgttcaag tgagagcagc agtgagctcc atgtgcagag   1500

aggcagggct ctggagtgag tggagccaac ctatttatgt ggggttctca agataaagga   1560

gataacatcc agctttcctg ccccacaccg tatctgaaat aaaaacaaca gcagggatag   1620

cagatt                                                              1626


<210>  8948
<211>  335
<212>  PRT
<213>  Homosapiens

<400>  8948

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Phe Ser Arg 
                325                 330                 335 


<210>  8949
<211>  2031
<212>  DNA
<213>  Homosapiens

<400>  8949
agtacccacg gaaaacttgt ttaccttgtc accatgagta aaagttaatt cccactcctg     60

aagagagcaa accaactctg aaagagagtg aaaatgcaga caagacagtt atcagataat    120

ggctatctgg acgagagatt ctttcgtttg acagcagttt ggttgttggg agttccagtt    180

cagctcctgc acagttgctc tgtacaaatc ctcctccata tttgcttaga gaaaacgtgt    240

tgccatccca tcatgaagga agctgcctga gagtttttaa ccattacagc cgtgatgatg    300

aaagagtgaa gaaccgcctc taagttaaaa agtgcaccca gagataaggt tcgttctcaa    360

tgccctgccg ctgcttctca tcgcatggcc accgcatttc tcaggccagg cacattgagc    420

attggtcctg tgcctgacgc tatgctagat gctggggttg cagccacgag catagacacg    480

acagacacgg tcctcgccat cttctgttga gtactggtcg gaacaagagg atcgtctgta    540

gacaggctac agattgtttt agattgaagt ttcctgtcat gttcactcat ctttaaatcc    600

tcatagtgaa aaaggatatg atcatcgtgg cgcatgtatt actcatcctt ttgggggcca    660

ctgagatact gcaagctgac ttacttcctg atgaaaagat ttcacttctc ccacctgtca    720

atttcaccat taaagttact ggtttggctc aagttctttt acaatggaaa ccaaatcctg    780

atcaagagca aaggaatgtt aatctagaat atcaagtgaa aataaacgct ccaaaagaag    840

atgactatga aaccagaatc actgaaagca aatgtgtaac catcctccac aaaggctttt    900

cagcaagtgt gcggaccatc ctgcagaacg accactcact actggccagc agctgggctt    960

ctgctgaact tcatgcccca ccagggtctc ctggaacctc aattgtgaat ttaacttgca   1020

ccacaaacac tacagaagac aattattcac gtttaaggtc ataccaagtt tcccttcact   1080

gcacctggct tgttggcaca gatgcccctg aggacacgca gtattttctc tactataggt   1140

atggctcttg gactgaagaa tgccaagaat acagcaaaga cacactgggg agaaatatcg   1200

catgctggtt tcccaggact tttatcctca gcaaagggcg tgactggctt gcggtgcttg   1260

ttaacggctc cagcaagcac tctgctatca ggccctttga tcagctgttt gcccttcacg   1320

ccattgatca aataaatcct ccactgaatg tcacagcaga gattgaagga actcgtctct   1380

ctatccaatg ggagaaacca gtgtctgctt ttccaatcca ttgctttgat tatgaagtaa   1440

aaatacacaa tacaaggaat ggatatttgc agatagaaaa attgatgacc aatgcattca   1500

tctcaataat tgatgatctt tctaagtacg atgttcaagt gagagcagca gtgagctcca   1560

tgtgcagaga ggcagggctc tggagtgagt ggagccaacc tatttatgtg ggtaagtagc   1620

ttatgtttat tttacattgg cagccttcct tgtgatcaaa aaaggtaatc ccagaaacgt   1680

acccgttcac tcgtgggtct taaaatggtt tcatatctct attgtgacta attttctctc   1740

ggtctactgc cttttcaatc aggaatagat ttgccatgaa gccagtgaag tttttaagtg   1800

tctaggcttc tcattagcgc caactctcct agacctggtg cctgtttttt ttccaagttt   1860

tgtttctact tctatccatt ttttaaatta aactttttat tttgaaataa ttatcacact   1920

cacaagctgt gggaagaaat aatagagatc ctgtgtctct ttcatccagt tttcctcaag   1980

ggtaacatct tacaaaacta tagtacaata gtggaataga atattggtgt t            2031


<210>  8950
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  8950

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Lys 
                325                 330             


<210>  8951
<211>  1956
<212>  DNA
<213>  Homosapiens

<400>  8951
agtacccacg gaaaacttgt ttaccttgtc accatgagta aaagttaatt cccactcctg     60

aagagagcaa accaactctg aaagagagtg aaaatgcaga caagacagtt atcagataat    120

ggctatctgg acgagagatt ctttcgtttg acagcagttt ggttgttggg agttccagtt    180

cagctcctgc acagttgctc tgtacaaatc ctcctccata tttgcttaga gaaaacgtgt    240

tgccatccca tcatgaagga agctgcctga gagtttttaa ccattacagc cgtgatgatg    300

aaagagtgaa gaaccgcctc taagttaaaa agtgcaccca gagataaggt tcgttctcaa    360

tgccctgccg ctgcttctca tcgcatggcc accgcatttc tcaggccagg cacattgagc    420

attggtcctg tgcctgacgc tatgctagat gctggggttg cagccacgag catagacacg    480

acagacacgg tcctcgccat cttctgttga gtactggtcg gaacaagagg atcgtctgta    540

gacaggatat gatcatcgtg gcgcatgtat tactcatcct tttgggggcc actgagatac    600

tgcaagctga cttacttcct gatgaaaaga tttcacttct cccacctgtc aatttcacca    660

ttaaagttac tggtttggct caagttcttt tacaatggaa accaaatcct gatcaagagc    720

aaaggaatgt taatctagaa tatcaagtga aaataaacgc tccaaaagaa gatgactatg    780

aaaccagaat cactgaaagc aaatgtgtaa ccatcctcca caaaggcttt tcagcaagtg    840

tgcggaccat cctgcagaac gaccactcac tactggccag cagctgggct tctgctgaac    900

ttcatgcccc accagggtct cctggaacct caattgtgaa tttaacttgc accacaaaca    960

ctacagaaga caattattca cgtttaaggt cataccaagt ttcccttcac tgcacctggc   1020

ttgttggcac agatgcccct gaggacacgc agtattttct ctactatagg tatggctctt   1080

ggactgaaga atgccaagaa tacagcaaag acacactggg gagaaatatc gcatgctggt   1140

ttcccaggac ttttatcctc agcaaagggc gtgactggct tgcggtgctt gttaacggct   1200

ccagcaagca ctctgctatc aggccctttg atcagctgtt tgcccttcac gccattgatc   1260

aaataaatcc tccactgaat gtcacagcag agattgaagg aactcgtctc tctatccaat   1320

gggagaaacc agtgtctgct tttccaatcc attgctttga ttatgaagta aaaatacaca   1380

atacaaggaa tggatatttg cagatagaaa aattgatgac caatgcattc atctcaataa   1440

ttgatgatct ttctaagtac gatgttcaag tgagagcagc agtgagctcc atgtgcagag   1500

aggcagggct ctggagtgag tggagccaac ctatttatgt gggtaagtag cttatgttta   1560

ttttacattg gcagccttcc ttgtgatcaa aaaaggtaat cccagaaacg tacccgttca   1620

ctcgtgggtc ttaaaatggt ttcatatctc tattgtgact aattttctct cggtctactg   1680

ccttttcaat caggaataga tttgccatga agccagtgaa gtttttaagt gtctaggctt   1740

ctcattagcg ccaactctcc tagacctggt gcctgttttt tttccaagtt ttgtttctac   1800

ttctatccat tttttaaatt aaacttttta ttttgaaata attatcacac tcacaagctg   1860

tgggaagaaa taatagagat cctgtgtctc tttcatccag ttttcctcaa gggtaacatc   1920

ttacaaaact atagtacaat agtggaatag aatatt                             1956


<210>  8952
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  8952

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Lys 
                325                 330             


<210>  8953
<211>  2194
<212>  DNA
<213>  Homosapiens

<400>  8953
accagcccgg aagtgcgcgt ggcggcggtg gcggctgcgg caacagcggg gccgatgtgt     60

agttggtgac tgcctctcca gatgctgagg tgcctgtatc attggcacag gccagtgctg    120

aaccgtaggt ggagtaggct gtgccttccg aagcagtatc tattcacaat gaagttgcag    180

tctcccgaat tccagtcact tttcacagaa ggactgaaga gtctgacaga attatttgtc    240

aaagagaatc acgaattaag aatagcagga ggagcagtga gggatttatt aaatggagta    300

aagcctcagg atatagattt tgccaccact gctaccccta ctcaaatgaa ggagatgttt    360

cagtcggctg ggattcggat gataaacaac agaggagaaa agcacggaac aattactgcc    420

aggcttcatg aagaaaattt tgagattact acactacgga ttgatgtcac cactgatgga    480

agacatgctg aggtagaatt tacaactgac tggcagaaag atgcggaacg cagagatctc    540

actataaatt ctatgttttt aggttttgat ggcactttat ttgactactt taatggttat    600

gaagatttaa aaaataagaa agttagattt gttggacatg ctaaacagag aatacaagag    660

gattatctta gaattttaag atacttcagg ttttatggga gaattgtaga caaacctggt    720

gaccatgatc ctgagacttt ggaagcaatt gcagaaaatg caaaaggctt ggctggaata    780

tcaggagaaa ggatttgggt ggaactgaaa aaaattcttg ttggtttacc tgctaatgca    840

agtttagaag aatttgacaa agtcagtaaa aatgttgatg gtttttcacc aaagccagtg    900

actcttttgg cctcattatt caaagtacaa gatgatgtca caaaattgga tttgaggttg    960

aagatcgcaa aagaggagaa aaaccttggc ttatttatag ttaaaaatag gaaagattta   1020

attaaagcaa cagatagttc agacccattg aaaccctatc aagacttcat tatagattct   1080

agggaacctg atgcaactac tcgtgtatgt gaactactga agtaccaagg agagcactgt   1140

ctcctaaagg aaatgcagca gtggtccatt cctccatttc ctgtaagtgg ccatgacatc   1200

agaaaagtgg gcatttcttc aggaaaagaa attggggctc tattacaaca gttgcgagaa   1260

cagtggaaaa aaagtggtta ccaaatggaa aaagatgaac ttctgagtta cataaagaag   1320

acctaaaact gatggctact aaaaagcaga gcatttctgg taagactaaa ttttctcccc   1380

tccctcttaa tgaggtttta gagactacac cagaataaaa gacagtttag gggacctctg   1440

tagaacaaca agggtcttat tttgtgaatt atatatttca agaactaaac agagatccac   1500

ctttctggat ctgatttata tcactgaaat gtacagttct tttggaatag tttcacctga   1560

gaaaacatag ttggctatta tctatcttaa cctgttcagg cttttaaaaa aaactgtttt   1620

tgcatagggt agtactaaga tcttaaaaag tggtaactgt cttgaagaaa aaacgtttat   1680

tgtttgtttg caattgaaat aacagggtta ccttaacaat gactgtctat gatgtgtcag   1740

ttcttatctg aattccaaaa taaacctgtg cttaaaaaag aaataattga ccaagtaagt   1800

ttgcataaaa tgtgaatact aaatgtgtcc ccagttgctg gcattcatat gtacaggatt   1860

tgttctagca agctatgctt cagtatgtgg ttgatatttt tctgtcacaa tgatttcttt   1920

atgcatgcag agcctgggga agtcatggga ttaacttgag ggtcactatt gagcctatta   1980

attaattatt gttttaataa aacaaacatt ggtattggaa gataaatatg tttatgtggt   2040

atctgacaat gtgtattagg tgtcatatac aatggtaata tgcctgtctt taaagtgtta   2100

ttttattaat taaaaggata tggctattat tatatattct ctaaagattt gagtcctaaa   2160

tgctttcatc aggtaaataa aatgtataat acaa                               2194


<210>  8954
<211>  414
<212>  PRT
<213>  Homosapiens

<400>  8954

Met Leu Arg Cys Leu Tyr His Trp His Arg Pro Val Leu Asn Arg Arg 
1               5                   10                  15      


Trp Ser Arg Leu Cys Leu Pro Lys Gln Tyr Leu Phe Thr Met Lys Leu 
            20                  25                  30          


Gln Ser Pro Glu Phe Gln Ser Leu Phe Thr Glu Gly Leu Lys Ser Leu 
        35                  40                  45              


Thr Glu Leu Phe Val Lys Glu Asn His Glu Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Val Arg Asp Leu Leu Asn Gly Val Lys Pro Gln Asp Ile Asp Phe 
65                  70                  75                  80  


Ala Thr Thr Ala Thr Pro Thr Gln Met Lys Glu Met Phe Gln Ser Ala 
                85                  90                  95      


Gly Ile Arg Met Ile Asn Asn Arg Gly Glu Lys His Gly Thr Ile Thr 
            100                 105                 110         


Ala Arg Leu His Glu Glu Asn Phe Glu Ile Thr Thr Leu Arg Ile Asp 
        115                 120                 125             


Val Thr Thr Asp Gly Arg His Ala Glu Val Glu Phe Thr Thr Asp Trp 
    130                 135                 140                 


Gln Lys Asp Ala Glu Arg Arg Asp Leu Thr Ile Asn Ser Met Phe Leu 
145                 150                 155                 160 


Gly Phe Asp Gly Thr Leu Phe Asp Tyr Phe Asn Gly Tyr Glu Asp Leu 
                165                 170                 175     


Lys Asn Lys Lys Val Arg Phe Val Gly His Ala Lys Gln Arg Ile Gln 
            180                 185                 190         


Glu Asp Tyr Leu Arg Ile Leu Arg Tyr Phe Arg Phe Tyr Gly Arg Ile 
        195                 200                 205             


Val Asp Lys Pro Gly Asp His Asp Pro Glu Thr Leu Glu Ala Ile Ala 
    210                 215                 220                 


Glu Asn Ala Lys Gly Leu Ala Gly Ile Ser Gly Glu Arg Ile Trp Val 
225                 230                 235                 240 


Glu Leu Lys Lys Ile Leu Val Gly Leu Pro Ala Asn Ala Ser Leu Glu 
                245                 250                 255     


Glu Phe Asp Lys Val Ser Lys Asn Val Asp Gly Phe Ser Pro Lys Pro 
            260                 265                 270         


Val Thr Leu Leu Ala Ser Leu Phe Lys Val Gln Asp Asp Val Thr Lys 
        275                 280                 285             


Leu Asp Leu Arg Leu Lys Ile Ala Lys Glu Glu Lys Asn Leu Gly Leu 
    290                 295                 300                 


Phe Ile Val Lys Asn Arg Lys Asp Leu Ile Lys Ala Thr Asp Ser Ser 
305                 310                 315                 320 


Asp Pro Leu Lys Pro Tyr Gln Asp Phe Ile Ile Asp Ser Arg Glu Pro 
                325                 330                 335     


Asp Ala Thr Thr Arg Val Cys Glu Leu Leu Lys Tyr Gln Gly Glu His 
            340                 345                 350         


Cys Leu Leu Lys Glu Met Gln Gln Trp Ser Ile Pro Pro Phe Pro Val 
        355                 360                 365             


Ser Gly His Asp Ile Arg Lys Val Gly Ile Ser Ser Gly Lys Glu Ile 
    370                 375                 380                 


Gly Ala Leu Leu Gln Gln Leu Arg Glu Gln Trp Lys Lys Ser Gly Tyr 
385                 390                 395                 400 


Gln Met Glu Lys Asp Glu Leu Leu Ser Tyr Ile Lys Lys Thr 
                405                 410                 


<210>  8955
<211>  1864
<212>  DNA
<213>  Homosapiens

<400>  8955
accagcccgg aagtgcgcgt ggcggcggtg gcggctgcgg caacagcggg gccgatgtgt     60

agttggtgac tgcctctcca gatgctgagg tgcctgtatc attggcacag gccagtgctg    120

aaccgtaggt ggagtaggct gtgccttccg aagcagtatc tattcacaat gaagttgcag    180

tctcccgaat tccagtcact tttcacagaa ggactgaaga gtctgacaga attatttgtc    240

aaagagaatc acgaattaag aatagcagga ggagcagtga gggatttatt aaatggagta    300

aagcctcagg atatagattt tgccaccact gctaccccta ctcaaatgaa ggagatgttt    360

cagtcggctg ggattcggat gataaacaac agaggagaaa agcacggaac aattactgcc    420

aggcttcatg aagaaaattt tgagattact acactacgga ttgatgtcac cactgatgga    480

agacatgctg aggtagaatt tacaactgac tggcagaaag atgcggaacg cagagatctc    540

actataaatt ctatgttttt aggttttgat ggcactttat ttgactactt taatggttat    600

gaagatttaa aaaataagaa agttagattt gttggacatg ctaaacagag aatacaagag    660

gattatctta gaattttaag atacttcagg ttttatggga gaattgtaga caaacctggt    720

gaccatgatc ctgagacttt ggaagcaatt gcagaaaatg caaaaggctt ggctggaata    780

tcaggagaaa ggatttgggt ggaactgaaa aaaattcttg ttggtaacca tgtaaatcat    840

ttgattcacc ttatctatga tcttgatgtg gctccttata taggtttacc tgctaatgca    900

agtttagaag aatttgacaa agtcagtaaa aatgttgatg gtttttcacc aaagccagtg    960

actcttttgg cctcattatt caaagtacaa gatgatgtca caaaattgga tttgaggttg   1020

aagatcgcaa aagaggagaa aaaccttggc ttatttatag ttaaaaatag gaaagattta   1080

attaaagcaa cagatagttc agacccattg aaaccctatc aagacttcat tatagattct   1140

agggaacctg atgcaactac tcgtgtatgt gaactactga agtaccaagg agagcactgt   1200

ctcctaaagg aaatgcagca gtggtccatt cctccatttc ctgtaagtgg ccatgacatc   1260

agaaaagtgg gcatttcttc aggaaaagaa attggggctc tattacaaca gttgcgagaa   1320

cagtggaaaa aaagtggtta ccaaatggaa aaagatgaac ttctgagtta cataaagaag   1380

acctaaaact gatggctact aaaaagcaga gcatttctgc cagtcataac atctttgtac   1440

tctatgagca aatagtaatt ttggaccttg ataaaacaat tttgtagagt gtaatatttc   1500

taagaggaaa tgtcacaggg gctatgatgc aagaaagcct cagaaatgac tgcatacagg   1560

aaataatctc atcatttcca aagatgtctt catgtcccat caatgacatg ctaccagaca   1620

tatcagattc cacaggataa tggcaccaag ctacccaagt agatgtttct ggtattctag   1680

actgccgttc atgcttgttt cctaaagtat acttaaaagt ttcaaataca gtttcactta   1740

gaaactgcaa ccctccaagt aatgttatgt ttacttaggt attaatgtta tgtttactta   1800

ggtatgtatc agaggcaata atttccaaag cagatcttag aatataacca atttgttaga   1860

taac                                                                1864


<210>  8956
<211>  434
<212>  PRT
<213>  Homosapiens

<400>  8956

Met Leu Arg Cys Leu Tyr His Trp His Arg Pro Val Leu Asn Arg Arg 
1               5                   10                  15      


Trp Ser Arg Leu Cys Leu Pro Lys Gln Tyr Leu Phe Thr Met Lys Leu 
            20                  25                  30          


Gln Ser Pro Glu Phe Gln Ser Leu Phe Thr Glu Gly Leu Lys Ser Leu 
        35                  40                  45              


Thr Glu Leu Phe Val Lys Glu Asn His Glu Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Val Arg Asp Leu Leu Asn Gly Val Lys Pro Gln Asp Ile Asp Phe 
65                  70                  75                  80  


Ala Thr Thr Ala Thr Pro Thr Gln Met Lys Glu Met Phe Gln Ser Ala 
                85                  90                  95      


Gly Ile Arg Met Ile Asn Asn Arg Gly Glu Lys His Gly Thr Ile Thr 
            100                 105                 110         


Ala Arg Leu His Glu Glu Asn Phe Glu Ile Thr Thr Leu Arg Ile Asp 
        115                 120                 125             


Val Thr Thr Asp Gly Arg His Ala Glu Val Glu Phe Thr Thr Asp Trp 
    130                 135                 140                 


Gln Lys Asp Ala Glu Arg Arg Asp Leu Thr Ile Asn Ser Met Phe Leu 
145                 150                 155                 160 


Gly Phe Asp Gly Thr Leu Phe Asp Tyr Phe Asn Gly Tyr Glu Asp Leu 
                165                 170                 175     


Lys Asn Lys Lys Val Arg Phe Val Gly His Ala Lys Gln Arg Ile Gln 
            180                 185                 190         


Glu Asp Tyr Leu Arg Ile Leu Arg Tyr Phe Arg Phe Tyr Gly Arg Ile 
        195                 200                 205             


Val Asp Lys Pro Gly Asp His Asp Pro Glu Thr Leu Glu Ala Ile Ala 
    210                 215                 220                 


Glu Asn Ala Lys Gly Leu Ala Gly Ile Ser Gly Glu Arg Ile Trp Val 
225                 230                 235                 240 


Glu Leu Lys Lys Ile Leu Val Gly Asn His Val Asn His Leu Ile His 
                245                 250                 255     


Leu Ile Tyr Asp Leu Asp Val Ala Pro Tyr Ile Gly Leu Pro Ala Asn 
            260                 265                 270         


Ala Ser Leu Glu Glu Phe Asp Lys Val Ser Lys Asn Val Asp Gly Phe 
        275                 280                 285             


Ser Pro Lys Pro Val Thr Leu Leu Ala Ser Leu Phe Lys Val Gln Asp 
    290                 295                 300                 


Asp Val Thr Lys Leu Asp Leu Arg Leu Lys Ile Ala Lys Glu Glu Lys 
305                 310                 315                 320 


Asn Leu Gly Leu Phe Ile Val Lys Asn Arg Lys Asp Leu Ile Lys Ala 
                325                 330                 335     


Thr Asp Ser Ser Asp Pro Leu Lys Pro Tyr Gln Asp Phe Ile Ile Asp 
            340                 345                 350         


Ser Arg Glu Pro Asp Ala Thr Thr Arg Val Cys Glu Leu Leu Lys Tyr 
        355                 360                 365             


Gln Gly Glu His Cys Leu Leu Lys Glu Met Gln Gln Trp Ser Ile Pro 
    370                 375                 380                 


Pro Phe Pro Val Ser Gly His Asp Ile Arg Lys Val Gly Ile Ser Ser 
385                 390                 395                 400 


Gly Lys Glu Ile Gly Ala Leu Leu Gln Gln Leu Arg Glu Gln Trp Lys 
                405                 410                 415     


Lys Ser Gly Tyr Gln Met Glu Lys Asp Glu Leu Leu Ser Tyr Ile Lys 
            420                 425                 430         


Lys Thr 
        


<210>  8957
<211>  975
<212>  DNA
<213>  Homosapiens

<400>  8957
gcgcgtggcg gcggtggcgg ctgcggcaac agcggggccg atgtgtagtt ggtgactgcc     60

tctccagatg ctgaggtgcc tgtatcattg gcacaggcca gtgctgaacc gtaggtggag    120

taggctgtgc cttccgaagc agtatctatt cacaatgaag ttgcagtctc ccgaattcca    180

gtcacttttc acagaaggac tgaagagtct gacaggtata aatgctttcc atgagaactg    240

aaggaagaag gaaataggag ttgcctccat tgtgcacgtt gcaaaacctg tctggaagga    300

gcataggaaa tggctttagc taagtgccag tagcttcttg ctgttgccac agtttcatta    360

gtgttgattc tcaatgttgt ctgctgatgt tgctaaagca gccacacagt agcattacaa    420

agcctgtggg aattttaata gcaccttcat aaatatattt agtagtatat gtagaaatat    480

gacctataca gcactggcta tctattagat tcacctgggg agcttttaaa gcacacatgc    540

tcgggttcta cctgcagcct actgaattag aatctctggg tgggatgacc atctatattt    600

ttaataaaag ctccacaagt taattctgat gcacagaaga tagacgaacc attactttaa    660

catgactcac cttgtattag cttattctca aagctacttt cccattcttg aaattggatg    720

atggcttttt aggtacgtgc cagagataaa tggcccagaa tatgttgatt cttttagatt    780

gttttaggca gactttaagt agagggctta aatgcatgtt tggttttgcc gatgcttcac    840

tatctttttt aattggagag agtgaaaatt gctaaaaatt gctgtccaat agaaatttat    900

gagcccatat gtaatataaa cttttttact aaccacatta aaaagataga aatggtgaaa    960

taaattttaa taatt                                                     975


<210>  8958
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  8958

Met Leu Arg Cys Leu Tyr His Trp His Arg Pro Val Leu Asn Arg Arg 
1               5                   10                  15      


Trp Ser Arg Leu Cys Leu Pro Lys Gln Tyr Leu Phe Thr Met Lys Leu 
            20                  25                  30          


Gln Ser Pro Glu Phe Gln Ser Leu Phe Thr Glu Gly Leu Lys Ser Leu 
        35                  40                  45              


Thr Gly Ile Asn Ala Phe His Glu Asn 
    50                  55          


<210>  8959
<211>  1374
<212>  DNA
<213>  Homosapiens

<400>  8959
gcgcgtggcg gcggtggcgg ctgcggcaac agcggggccg atgtgtagtt ggtgactgcc     60

tctccagatg ctgaggtgcc tgtatcattg gcacaggcca gtgctgaacc gtaggtggag    120

taggctgtgc cttccgaagc agtatctatt cacaatgaag ttgcagtctc ccgaattcca    180

gtcacttttc acagaaggac tgaagagtct gacaggtata aatgctttcc atgagaactg    240

aaggaagaag gaaataggag ttgcctccat tgtgcacgtt gcaaaacctg tctggaagga    300

gcataggaaa tggctttagc taagtgccag tagcttcttg ctgttgccac agtttcatta    360

gtgttgattc tcaatgttgt ctgctgatgt tgctaaagca gccacacagt agcattacaa    420

agcctgtggg aattttaata gcaccttcat aaatatattt agtagtatat gtagaaatat    480

gacctataca gcactggcta tctattagat tcacctgggg agcttttaaa gcacacatgc    540

tcgggttcta cctgcagcct actgaattag aatctctggg tgggatgacc atctatattt    600

ttaataaaag ctccacaagt taattctgat gcacagaaga tagacgaacc attactttaa    660

catgactcac cttgtattag cttattctca aagctacttt cccattcttg aaattggatg    720

atggcttttt aggtacgtgc cagagataaa tggcccagaa tatgttgatt cttttagatt    780

gttttaggca gactttaagt agagggctta aatgcatgtt tggttttgcc gatgcttcac    840

tatctttttt aattggagag agtgaaaatt gctaaaaatt gctgtccaat agaaatttat    900

gagcccatat gtaatataaa cttttttact aaccacatta aaaagataga aatggtgaaa    960

taaattttaa taattatttt tggttcatct aatttaatcc aatatatcta agatactatc   1020

agtatgaatt ttgtataaaa attgttaatg aggccgggca cagtgtctcc cacctgtaat   1080

cctagcactt tgggaggctg gacatggtgg ctcatacctg taatcccagc acttttgagt   1140

ggctgaggtg ggtggatcac ttgagcccag gagtttgaga ccagcctggg caacacggtg   1200

aaaccccatc tctactaaaa atatgaaaaa taggcaagca tactgatatg tgtctgtagt   1260

ccctgctact tgggaggctg aggtgggagg atcactgaag cctgggaggg gggcttgcgg   1320

taagccgaga ttgtgccact acactccagc ctgggcgaca cagaccgtgt cttt         1374


<210>  8960
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  8960

Met Leu Arg Cys Leu Tyr His Trp His Arg Pro Val Leu Asn Arg Arg 
1               5                   10                  15      


Trp Ser Arg Leu Cys Leu Pro Lys Gln Tyr Leu Phe Thr Met Lys Leu 
            20                  25                  30          


Gln Ser Pro Glu Phe Gln Ser Leu Phe Thr Glu Gly Leu Lys Ser Leu 
        35                  40                  45              


Thr Gly Ile Asn Ala Phe His Glu Asn 
    50                  55          


<210>  8961
<211>  1988
<212>  DNA
<213>  Homosapiens

<400>  8961
ggcggctgcg gcaacagcgg ggccggtaag cgggcgcgcg ccgctcagag gggcagagtt     60

ggtggcgtga gttgctgccc cttccttcct gctgtgggcc agaggcgcca ccgcgcccgg    120

tcctcgagga agacgggagc gggacgtggc gagaggcctc ctcagcagtg ggcaaaatag    180

ccccgacgcg gaggtcgtgt ccccgccacg tttccggcga ccgcaggcgc ggattccttg    240

gcttccctca gcactttccc ctccgcgcgg acggccccga gacgcttttt cactgggcct    300

tgtcgccagc acccggcgtg gggggtgaga cgcgcctttt cagggctggg gttccccaga    360

gcgttttcct aagtcgaggc ggaggtgcga ggaaactgag tgggtctttc cgccccacgt    420

ggcctgccgg gaagcgcggc tcctccaccc gcttccgtgg aatggaatgg tttttctctg    480

caggtttaca ccggggtcac tcgagagctg ctgcggcctc cttatgggca ggacccccgt    540

atggggagaa cgaggatgtg atatgtagaa gggaaggccg cggtgtgcca gaaatcagag    600

gagattgcaa gatggcagga aaagaatcag gaaaatgggg gcagcaaaac taaattcatg    660

ggaaaataca atgtctagga gctatcccag ggtcgtgaat cctcgagtgc aggtggggaa    720

gtagggtgat acccacctgt gaccatgaca agttttggag accagaaact cggttagagt    780

ttctagaacc ccgcatccct ctcatactgc ctgaagccct gctctgggga gagtgtcatc    840

acagtaccat gtggcatgcg agtgtcgtgg taatgctccc cgaccaaacc accaaaccga    900

gggttgggct gcttattctc gctgcccaat aatgagatgc agataaacta ggaaagaaag    960

gagtttattt ctgtaaccag gtacggggcg aaggcgtgga aaatatccca gaccgactca   1020

gaattacaga gctttccaga gcttatatac cttatgtgta gttggtgact gcctctccag   1080

atgctgaggt gcctgtatca ttggcacagg ccagtgctga accgtaggtg gagtaggctg   1140

tgccttccga agcagtatct attcacaatg aagttgcagt ctcccgaatt ccagtcactt   1200

ttcacagaag gactgaagag tctgacaggt ataaatgctt tccatgagaa ctgaaggaag   1260

aaggaaatag gagttgcctc cattgtgcac gttgcaaaac ctgtctggaa ggagcatagg   1320

aaatggcttt agctaagtgc cagtagcttc ttgctgttgc cacagtttca ttagtgttga   1380

ttctcaatgt tgtctgctga tgttgctaaa gcagccacac agtagcatta caaagcctgt   1440

gggaatttta atagcacctt cataaatata tttagtagta tatgtagaaa tatgacctat   1500

acagcactgg ctatctatta gattcacctg gggagctttt aaagcacaca tgctcgggtt   1560

ctacctgcag cctactgaat tagaatctct gggtgggatg accatctata tttttaataa   1620

aagctccaca agttaattct gatgcacaga agatagacga accattactt taacatgact   1680

caccttgtat tagcttattc tcaaagctac tttcccattc ttgaaattgg atgatggctt   1740

tttaggtacg tgccagagat aaatggccca gaatatgttg attcttttag attgttttag   1800

gcagacttta agtagagggc ttaaatgcat gtttggtttt gccgatgctt cactatcttt   1860

tttaattgga gagagtgaaa attgctaaaa attgctgtcc aatagaaatt tatgagccca   1920

tatgtaatat aaactttttt actaaccaca ttaaaaagat agaaatggtg aaataaattt   1980

taataatt                                                            1988


<210>  8962
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  8962

Met Leu Arg Cys Leu Tyr His Trp His Arg Pro Val Leu Asn Arg Arg 
1               5                   10                  15      


Trp Ser Arg Leu Cys Leu Pro Lys Gln Tyr Leu Phe Thr Met Lys Leu 
            20                  25                  30          


Gln Ser Pro Glu Phe Gln Ser Leu Phe Thr Glu Gly Leu Lys Ser Leu 
        35                  40                  45              


Thr Gly Ile Asn Ala Phe His Glu Asn 
    50                  55          


<210>  8963
<211>  2387
<212>  DNA
<213>  Homosapiens

<400>  8963
ggcggctgcg gcaacagcgg ggccggtaag cgggcgcgcg ccgctcagag gggcagagtt     60

ggtggcgtga gttgctgccc cttccttcct gctgtgggcc agaggcgcca ccgcgcccgg    120

tcctcgagga agacgggagc gggacgtggc gagaggcctc ctcagcagtg ggcaaaatag    180

ccccgacgcg gaggtcgtgt ccccgccacg tttccggcga ccgcaggcgc ggattccttg    240

gcttccctca gcactttccc ctccgcgcgg acggccccga gacgcttttt cactgggcct    300

tgtcgccagc acccggcgtg gggggtgaga cgcgcctttt cagggctggg gttccccaga    360

gcgttttcct aagtcgaggc ggaggtgcga ggaaactgag tgggtctttc cgccccacgt    420

ggcctgccgg gaagcgcggc tcctccaccc gcttccgtgg aatggaatgg tttttctctg    480

caggtttaca ccggggtcac tcgagagctg ctgcggcctc cttatgggca ggacccccgt    540

atggggagaa cgaggatgtg atatgtagaa gggaaggccg cggtgtgcca gaaatcagag    600

gagattgcaa gatggcagga aaagaatcag gaaaatgggg gcagcaaaac taaattcatg    660

ggaaaataca atgtctagga gctatcccag ggtcgtgaat cctcgagtgc aggtggggaa    720

gtagggtgat acccacctgt gaccatgaca agttttggag accagaaact cggttagagt    780

ttctagaacc ccgcatccct ctcatactgc ctgaagccct gctctgggga gagtgtcatc    840

acagtaccat gtggcatgcg agtgtcgtgg taatgctccc cgaccaaacc accaaaccga    900

gggttgggct gcttattctc gctgcccaat aatgagatgc agataaacta ggaaagaaag    960

gagtttattt ctgtaaccag gtacggggcg aaggcgtgga aaatatccca gaccgactca   1020

gaattacaga gctttccaga gcttatatac cttatgtgta gttggtgact gcctctccag   1080

atgctgaggt gcctgtatca ttggcacagg ccagtgctga accgtaggtg gagtaggctg   1140

tgccttccga agcagtatct attcacaatg aagttgcagt ctcccgaatt ccagtcactt   1200

ttcacagaag gactgaagag tctgacaggt ataaatgctt tccatgagaa ctgaaggaag   1260

aaggaaatag gagttgcctc cattgtgcac gttgcaaaac ctgtctggaa ggagcatagg   1320

aaatggcttt agctaagtgc cagtagcttc ttgctgttgc cacagtttca ttagtgttga   1380

ttctcaatgt tgtctgctga tgttgctaaa gcagccacac agtagcatta caaagcctgt   1440

gggaatttta atagcacctt cataaatata tttagtagta tatgtagaaa tatgacctat   1500

acagcactgg ctatctatta gattcacctg gggagctttt aaagcacaca tgctcgggtt   1560

ctacctgcag cctactgaat tagaatctct gggtgggatg accatctata tttttaataa   1620

aagctccaca agttaattct gatgcacaga agatagacga accattactt taacatgact   1680

caccttgtat tagcttattc tcaaagctac tttcccattc ttgaaattgg atgatggctt   1740

tttaggtacg tgccagagat aaatggccca gaatatgttg attcttttag attgttttag   1800

gcagacttta agtagagggc ttaaatgcat gtttggtttt gccgatgctt cactatcttt   1860

tttaattgga gagagtgaaa attgctaaaa attgctgtcc aatagaaatt tatgagccca   1920

tatgtaatat aaactttttt actaaccaca ttaaaaagat agaaatggtg aaataaattt   1980

taataattat ttttggttca tctaatttaa tccaatatat ctaagatact atcagtatga   2040

attttgtata aaaattgtta atgaggccgg gcacagtgtc tcccacctgt aatcctagca   2100

ctttgggagg ctggacatgg tggctcatac ctgtaatccc agcacttttg agtggctgag   2160

gtgggtggat cacttgagcc caggagtttg agaccagcct gggcaacacg gtgaaacccc   2220

atctctacta aaaatatgaa aaataggcaa gcatactgat atgtgtctgt agtccctgct   2280

acttgggagg ctgaggtggg aggatcactg aagcctggga ggggggcttg cggtaagccg   2340

agattgtgcc actacactcc agcctgggcg acacagaccg tgtcttt                 2387


<210>  8964
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  8964

Met Leu Arg Cys Leu Tyr His Trp His Arg Pro Val Leu Asn Arg Arg 
1               5                   10                  15      


Trp Ser Arg Leu Cys Leu Pro Lys Gln Tyr Leu Phe Thr Met Lys Leu 
            20                  25                  30          


Gln Ser Pro Glu Phe Gln Ser Leu Phe Thr Glu Gly Leu Lys Ser Leu 
        35                  40                  45              


Thr Gly Ile Asn Ala Phe His Glu Asn 
    50                  55          


<210>  8965
<211>  1318
<212>  DNA
<213>  Homosapiens

<400>  8965
cagcggggcc ggtaagcggg cgcgcgccgc tcagaggggc agagttggtg gcgtgagttg     60

ctgccccttc cttcctgctg tgggccagag gcgccaccgc gcccggtcct cgaggaagac    120

gggagcggga cgtggcgaga ggcctcctca gcagtgggca aaatagcccc gacgcggagg    180

tcgtgtcccc gccacgtttc cggcgaccgc aggcgcggat tccttggctt ccctcagcac    240

tttcccctcc gcgcggacgg ccccgagacg ctttttcact gggccttgtc gccagcaccc    300

ggcgtggggg gtacggggcg aaggcgtgga aaatatccca gaccgactca gaattacaga    360

gctttccaga gcttatatac cttatgtgta gttggtgact gcctctccag atgctgaggt    420

gcctgtatca ttggcacagg ccagtgctga accgtaggtg gagtaggctg tgccttccga    480

agcagtatct attcacaatg aagttgcagt ctcccgaatt ccagtcactt ttcacagaag    540

gactgaagag tctgacaggt ataaatgctt tccatgagaa ctgaaggaag aaggaaatag    600

gagttgcctc cattgtgcac gttgcaaaac ctgtctggaa ggagcatagg aaatggcttt    660

agctaagtgc cagtagcttc ttgctgttgc cacagtttca ttagtgttga ttctcaatgt    720

tgtctgctga tgttgctaaa gcagccacac agtagcatta caaagcctgt gggaatttta    780

atagcacctt cataaatata tttagtagta tatgtagaaa tatgacctat acagcactgg    840

ctatctatta gattcacctg gggagctttt aaagcacaca tgctcgggtt ctacctgcag    900

cctactgaat tagaatctct gggtgggatg accatctata tttttaataa aagctccaca    960

agttaattct gatgcacaga agatagacga accattactt taacatgact caccttgtat   1020

tagcttattc tcaaagctac tttcccattc ttgaaattgg atgatggctt tttaggtacg   1080

tgccagagat aaatggccca gaatatgttg attcttttag attgttttag gcagacttta   1140

agtagagggc ttaaatgcat gtttggtttt gccgatgctt cactatcttt tttaattgga   1200

gagagtgaaa attgctaaaa attgctgtcc aatagaaatt tatgagccca tatgtaatat   1260

aaactttttt actaaccaca ttaaaaagat agaaatggtg aaataaattt taataatt     1318


<210>  8966
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  8966

Met Leu Arg Cys Leu Tyr His Trp His Arg Pro Val Leu Asn Arg Arg 
1               5                   10                  15      


Trp Ser Arg Leu Cys Leu Pro Lys Gln Tyr Leu Phe Thr Met Lys Leu 
            20                  25                  30          


Gln Ser Pro Glu Phe Gln Ser Leu Phe Thr Glu Gly Leu Lys Ser Leu 
        35                  40                  45              


Thr Gly Ile Asn Ala Phe His Glu Asn 
    50                  55          


<210>  8967
<211>  1717
<212>  DNA
<213>  Homosapiens

<400>  8967
cagcggggcc ggtaagcggg cgcgcgccgc tcagaggggc agagttggtg gcgtgagttg     60

ctgccccttc cttcctgctg tgggccagag gcgccaccgc gcccggtcct cgaggaagac    120

gggagcggga cgtggcgaga ggcctcctca gcagtgggca aaatagcccc gacgcggagg    180

tcgtgtcccc gccacgtttc cggcgaccgc aggcgcggat tccttggctt ccctcagcac    240

tttcccctcc gcgcggacgg ccccgagacg ctttttcact gggccttgtc gccagcaccc    300

ggcgtggggg gtacggggcg aaggcgtgga aaatatccca gaccgactca gaattacaga    360

gctttccaga gcttatatac cttatgtgta gttggtgact gcctctccag atgctgaggt    420

gcctgtatca ttggcacagg ccagtgctga accgtaggtg gagtaggctg tgccttccga    480

agcagtatct attcacaatg aagttgcagt ctcccgaatt ccagtcactt ttcacagaag    540

gactgaagag tctgacaggt ataaatgctt tccatgagaa ctgaaggaag aaggaaatag    600

gagttgcctc cattgtgcac gttgcaaaac ctgtctggaa ggagcatagg aaatggcttt    660

agctaagtgc cagtagcttc ttgctgttgc cacagtttca ttagtgttga ttctcaatgt    720

tgtctgctga tgttgctaaa gcagccacac agtagcatta caaagcctgt gggaatttta    780

atagcacctt cataaatata tttagtagta tatgtagaaa tatgacctat acagcactgg    840

ctatctatta gattcacctg gggagctttt aaagcacaca tgctcgggtt ctacctgcag    900

cctactgaat tagaatctct gggtgggatg accatctata tttttaataa aagctccaca    960

agttaattct gatgcacaga agatagacga accattactt taacatgact caccttgtat   1020

tagcttattc tcaaagctac tttcccattc ttgaaattgg atgatggctt tttaggtacg   1080

tgccagagat aaatggccca gaatatgttg attcttttag attgttttag gcagacttta   1140

agtagagggc ttaaatgcat gtttggtttt gccgatgctt cactatcttt tttaattgga   1200

gagagtgaaa attgctaaaa attgctgtcc aatagaaatt tatgagccca tatgtaatat   1260

aaactttttt actaaccaca ttaaaaagat agaaatggtg aaataaattt taataattat   1320

ttttggttca tctaatttaa tccaatatat ctaagatact atcagtatga attttgtata   1380

aaaattgtta atgaggccgg gcacagtgtc tcccacctgt aatcctagca ctttgggagg   1440

ctggacatgg tggctcatac ctgtaatccc agcacttttg agtggctgag gtgggtggat   1500

cacttgagcc caggagtttg agaccagcct gggcaacacg gtgaaacccc atctctacta   1560

aaaatatgaa aaataggcaa gcatactgat atgtgtctgt agtccctgct acttgggagg   1620

ctgaggtggg aggatcactg aagcctggga ggggggcttg cggtaagccg agattgtgcc   1680

actacactcc agcctgggcg acacagaccg tgtcttt                            1717


<210>  8968
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  8968

Met Leu Arg Cys Leu Tyr His Trp His Arg Pro Val Leu Asn Arg Arg 
1               5                   10                  15      


Trp Ser Arg Leu Cys Leu Pro Lys Gln Tyr Leu Phe Thr Met Lys Leu 
            20                  25                  30          


Gln Ser Pro Glu Phe Gln Ser Leu Phe Thr Glu Gly Leu Lys Ser Leu 
        35                  40                  45              


Thr Gly Ile Asn Ala Phe His Glu Asn 
    50                  55          


<210>  8969
<211>  1614
<212>  DNA
<213>  Homosapiens

<400>  8969
ataaatgtac ttccctttgc tgtaaacaat gtcaagaaac agaaataaca accaaaaatg     60

aaatattcag tttatcctta tgtgggccga tggcagctta tgtgaatcct catggatatg    120

tgcatgagac acttactgtg tataaggctt gcaacttgaa tctgataggc cggccttcta    180

cagaacacag ctggtttcct gggtatgcct ggactgttgc ccagtgtaag atctgtgcaa    240

gccatattgg atggaagttt acggccacca aaaaagacat gtcacctcaa aaattttggg    300

gcttaacgcg atctgctctg ttgcccacga tcccagacac tgaagatgaa ataagtccag    360

acaaagtaat actttgcttg taaacagatg tgatagagat aaagttatct aacaaattgg    420

ttatattcta agatctgctt tggaaattat tgcctctgat acatacctaa gtaaacataa    480

cattaatacc taagtaaaca taacattact tggagggttg cagtttctaa gtgaaactgt    540

atttgaaact tttaagtata ctttaggaaa caagcatgaa cggcagtcta gaataccaga    600

aacatctact tgggtagctt ggtgccatta tcctgtggaa tctgatatgt ctggtagcat    660

gtcattgatg ggacatgaag acatctttgg aaatgatgag attatttcct gtgttaaaaa    720

aaaaaaaaat cttaaattcc tacaatgtga aactgaaact aataatttga tcctgatgta    780

tgggacagcg tatctgtacc agtgctctaa ataacaaaag ctagggtgac aagtacatgt    840

tccttttgga aagaagcaag gcaatgtata ttaattattc taaaagggct ttgttccttt    900

ccattttctt taacttctct gagatactga tttgtaaatt ttgaaaatta gttaaaatat    960

gcagtttttt gagcccacga atagttgtca tttcctttat gtgcctgtta gtaaaaagta   1020

gtattgtgta tttgctcagt atctgaacta taagcccatt tatactgttc catacaaaag   1080

ctatttttca aaaattaatt tgaaccaaaa ctactactat agggaaaaga tgccaaaaca   1140

tgtcccctca cccagactaa acttgatact gtattatttt gttcaatgta aattgaagaa   1200

aatctgtaag taagtaaacc ttaagtgtga aactaaacat gttctttgtt caaataatgt   1260

aaaatatcta ctcataattt taaagttcta aaaaggctgc tttgccacct acctctttgc   1320

ttatattcaa gggtttagtg ggtccttcct tccacatttg tatgataact ttcgttttat   1380

tggtagtcct ttgctacttt aaaactaatc aggttaaatg tttactcaaa tgtagtaata   1440

gtatgaggcc aaaatacatg ccttgaaggt ggagtgaaat cagttgagtg tcacactgca   1500

tatttatgta aatagagtaa atgaaaattc aagaatactt ccaatcagga tatgcccctg   1560

ccttattttt tctaaggtct acttttacta ctttaataat tttgggtttg tgtg         1614


<210>  8970
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  8970

Met Ala Ala Tyr Val Asn Pro His Gly Tyr Val His Glu Thr Leu Thr 
1               5                   10                  15      


Val Tyr Lys Ala Cys Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu 
            20                  25                  30          


His Ser Trp Phe Pro Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile 
        35                  40                  45              


Cys Ala Ser His Ile Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met 
    50                  55                  60                  


Ser Pro Gln Lys Phe Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr 
65                  70                  75                  80  


Ile Pro Asp Thr Glu Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys 
                85                  90                  95      


Leu 
    


<210>  8971
<211>  2417
<212>  DNA
<213>  Homosapiens

<400>  8971
ctcttccttc aaatccaata ggtatgaaaa gttagtttcc tgcctggagc ctgggatgtc     60

ttgctataaa aaatagcttt ttcatggatg cgatccaatc atatcttcta ggttttaaga    120

ctgattaaaa cattttaatt ctgaaaagca taatttcctt tgagcagttg aaaaaaaatg    180

agtattttaa aattaattgc aataaaatcc tcatattctg tgagcactcc aattttagac    240

aagttttcca taaaaagttc aaattgcagg aagtggctgt catccaaaaa cacttcctgt    300

gtaaggactc ctttccctgt tcttcaaggt gcctttaaaa gaagtgagtc tagttccagg    360

acttgcctta attatagata ctctctttat ctgtttataa ggtatagttt agttattttt    420

ctagtctctt ggcaaataac ttctaacatg gatttgagtt catgtttaac ataaaaggat    480

tttaccaaaa aaagtataag aaaagcaatt aaatttagag cttctgaaaa gtgtatcttt    540

gacagctggt atatttttgt attgtttata cttgtataaa atgtgtaacc ttaaagagaa    600

gggtttattt caaaaggata ttatccgatt tgtaagttct ctgatgctta tctgactcct    660

aagtttaaaa cttgaaaaac catgtcttga agatttttct tacagagtag ctgcttgtct    720

tcctattgat gatgtattga gaattcagct ccttaaaatt ggcagtgcta tccagcgact    780

tcgctgtgaa ttagacatta tgaataaatg tacttccctt tgctgtaaac aatgtcaaga    840

aacagaaata acaaccaaaa atgaaatatt cagtttatcc ttatgtgggc cgatggcagc    900

ttatgtgaat cctcatggat atgtgcatga gacacttact gtgtataagg cttgcaactt    960

gaatctgata ggccggcctt ctacagaaca cagctggttt cctgggtatg cctggactgt   1020

tgcccagtgt aagatctgtg caagccatat tggatggaag tttacggcca ccaaaaaaga   1080

catgtcacct caaaaatttt ggggcttaac gcgatctgct ctgttgccca cgatcccaga   1140

cactgaagat gaaataagtc cagacaaagt aatactttgc ttgtaaacag atgtgataga   1200

gataaagtta tctaacaaat tggttatatt ctaagatctg ctttggaaat tattgcctct   1260

gatacatacc taagtaaaca taacattaat acctaagtaa acataacatt acttggaggg   1320

ttgcagtttc taagtgaaac tgtatttgaa acttttaagt atactttagg aaacaagcat   1380

gaacggcagt ctagaatacc agaaacatct acttgggtag cttggtgcca ttatcctgtg   1440

gaatctgata tgtctggtag catgtcattg atgggacatg aagacatctt tggaaatgat   1500

gagattattt cctgtgttaa aaaaaaaaaa aatcttaaat tcctacaatg tgaaactgaa   1560

actaataatt tgatcctgat gtatgggaca gcgtatctgt accagtgctc taaataacaa   1620

aagctagggt gacaagtaca tgttcctttt ggaaagaagc aaggcaatgt atattaatta   1680

ttctaaaagg gctttgttcc tttccatttt ctttaacttc tctgagatac tgatttgtaa   1740

attttgaaaa ttagttaaaa tatgcagttt tttgagccca cgaatagttg tcatttcctt   1800

tatgtgcctg ttagtaaaaa gtagtattgt gtatttgctc agtatctgaa ctataagccc   1860

atttatactg ttccatacaa aagctatttt tcaaaaatta atttgaacca aaactactac   1920

tatagggaaa agatgccaaa acatgtcccc tcacccagac taaacttgat actgtattat   1980

tttgttcaat gtaaattgaa gaaaatctgt aagtaagtaa accttaagtg tgaaactaaa   2040

catgttcttt gttcaaataa tgtaaaatat ctactcataa ttttaaagtt ctaaaaaggc   2100

tgctttgcca cctacctctt tgcttatatt caagggttta gtgggtcctt ccttccacat   2160

ttgtatgata actttcgttt tattggtagt cctttgctac tttaaaacta atcaggttaa   2220

atgtttactc aaatgtagta atagtatgag gccaaaatac atgccttgaa ggtggagtga   2280

aatcagttga gtgtcacact gcatatttat gtaaatagag taaatgaaaa ttcaagaata   2340

cttccaatca ggatatgccc ctgccttatt ttttctaagg tctactttta ctactttaat   2400

aattttgggt ttgtgtg                                                  2417


<210>  8972
<211>  128
<212>  PRT
<213>  Homosapiens

<400>  8972

Met Asn Lys Cys Thr Ser Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu 
1               5                   10                  15      


Ile Thr Thr Lys Asn Glu Ile Phe Ser Leu Ser Leu Cys Gly Pro Met 
            20                  25                  30          


Ala Ala Tyr Val Asn Pro His Gly Tyr Val His Glu Thr Leu Thr Val 
        35                  40                  45              


Tyr Lys Ala Cys Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His 
    50                  55                  60                  


Ser Trp Phe Pro Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys 
65                  70                  75                  80  


Ala Ser His Ile Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser 
                85                  90                  95      


Pro Gln Lys Phe Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile 
            100                 105                 110         


Pro Asp Thr Glu Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        115                 120                 125             


<210>  8973
<211>  1949
<212>  DNA
<213>  Homosapiens

<400>  8973
atggaggcat ttaaactggg actgagatgg gactgagtga ttaaattgct accagtgtta     60

gttttaagag ttgaaaagct taatagtaaa ttttaataag cccatgaact tgattatggc    120

tacctttatt ttaaacaagg agaccttaat ggacagaatc aagaaacagc tacgtgaatg    180

ggatgaaaat ctaaaagatg attctcttcc ttcaaatcca atagattttt cttacagagt    240

agctgcttgt cttcctattg atgatgtatt gagaattcag ctccttaaaa ttggcagtgc    300

tatccagcga cttcgctgtg aattagacat tatgaataaa tgtacttccc tttgctgtaa    360

acaatgtcaa gaaacagaaa taacaaccaa aaatgaaata ttcagtttat ccttatgtgg    420

gccgatggca gcttatgtga atcctcatgg atatgtgcat gagacactta ctgtgtataa    480

ggcttgcaac ttgaatctga taggccggcc ttctacagaa cacagctggt ttcctgggta    540

tgcctggact gttgcccagt gtaagatctg tgcaagccat attggatgga agtttacggc    600

caccaaaaaa gacatgtcac ctcaaaaatt ttggggctta acgcgatctg ctctgttgcc    660

cacgatccca gacactgaag atgaaataag tccagacaaa gtaatacttt gcttgtaaac    720

agatgtgata gagataaagt tatctaacaa attggttata ttctaagatc tgctttggaa    780

attattgcct ctgatacata cctaagtaaa cataacatta atacctaagt aaacataaca    840

ttacttggag ggttgcagtt tctaagtgaa actgtatttg aaacttttaa gtatacttta    900

ggaaacaagc atgaacggca gtctagaata ccagaaacat ctacttgggt agcttggtgc    960

cattatcctg tggaatctga tatgtctggt agcatgtcat tgatgggaca tgaagacatc   1020

tttggaaatg atgagattat ttcctgtgtt aaaaaaaaaa aaaatcttaa attcctacaa   1080

tgtgaaactg aaactaataa tttgatcctg atgtatggga cagcgtatct gtaccagtgc   1140

tctaaataac aaaagctagg gtgacaagta catgttcctt ttggaaagaa gcaaggcaat   1200

gtatattaat tattctaaaa gggctttgtt cctttccatt ttctttaact tctctgagat   1260

actgatttgt aaattttgaa aattagttaa aatatgcagt tttttgagcc cacgaatagt   1320

tgtcatttcc tttatgtgcc tgttagtaaa aagtagtatt gtgtatttgc tcagtatctg   1380

aactataagc ccatttatac tgttccatac aaaagctatt tttcaaaaat taatttgaac   1440

caaaactact actataggga aaagatgcca aaacatgtcc cctcacccag actaaacttg   1500

atactgtatt attttgttca atgtaaattg aagaaaatct gtaagtaagt aaaccttaag   1560

tgtgaaacta aacatgttct ttgttcaaat aatgtaaaat atctactcat aattttaaag   1620

ttctaaaaag gctgctttgc cacctacctc tttgcttata ttcaagggtt tagtgggtcc   1680

ttccttccac atttgtatga taactttcgt tttattggta gtcctttgct actttaaaac   1740

taatcaggtt aaatgtttac tcaaatgtag taatagtatg aggccaaaat acatgccttg   1800

aaggtggagt gaaatcagtt gagtgtcaca ctgcatattt atgtaaatag agtaaatgaa   1860

aattcaagaa tacttccaat caggatatgc ccctgcctta ttttttctaa ggtctacttt   1920

tactacttta ataattttgg gtttgtgtg                                     1949


<210>  8974
<211>  204
<212>  PRT
<213>  Homosapiens

<400>  8974

Met Asn Leu Ile Met Ala Thr Phe Ile Leu Asn Lys Glu Thr Leu Met 
1               5                   10                  15      


Asp Arg Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp 
            20                  25                  30          


Asp Ser Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala 
        35                  40                  45              


Cys Leu Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly 
    50                  55                  60                  


Ser Ala Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys 
65                  70                  75                  80  


Thr Ser Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys 
                85                  90                  95      


Asn Glu Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val 
            100                 105                 110         


Asn Pro His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys 
        115                 120                 125             


Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro 
    130                 135                 140                 


Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile 
145                 150                 155                 160 


Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe 
                165                 170                 175     


Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu 
            180                 185                 190         


Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        195                 200                 


<210>  8975
<211>  4196
<212>  DNA
<213>  Homosapiens

<400>  8975
tcccagcact ttgggaggcc aaggcagggg gattgcttga agccaggcat tcaagaccag     60

cctgggcaac atggtgaaac cccatctcta caaatacaaa aattagccag gtttggtggc    120

atgtggctgt agtcccagct gcttgagagg ctgaggtgga aggattgatt gagcctggga    180

ggtcaaggct gccgtgagct gagattgtgt cactgtactc cagcctggac aacagagcaa    240

gactgtctca aaagggaaaa aaaaaggtat cacaagactc tttagagttt tattaagcat    300

gtgaaatttt gttgggttgg gtgatagtta catttagaac attaaagcat ccatatttta    360

ctgttttggt ttttctctaa acaagtatat taacttacgt ctcttgatca ttagtctatt    420

aattaatgca tccaggaggg tttttgctcc ttaaagttta acactaggca ttgccacatt    480

ttgcaaaact aagggacagt gctgaaatgg tttaaagaat ctggatttca gatcagagac    540

tgacttcaga gtctgatttc tgtcacttac tctgtgggcc tggagcaaat tacttctcca    600

aggacctatg aaatggatat aatggtagct attgtacctg gtgtgcatag cgggcattca    660

ataaatgcta gccatttccc ttaatgaatc actgcccaca aatctggagt cctgggaaaa    720

ctcaacaaca tgcacgacac taaaggaaac tgcagttgat ctccgctctt tagcagcttt    780

tcagcaatta caaagacaca atatatgagt ttttgcatgt tttgcatatg cttgtgaaaa    840

ttatgtagta aataggtgcc aagtaaggta tgtagatagc aagtgctagt gcaatttata    900

ggtgccataa tccctatgga ctgggtcaga aatggcctaa tagaaggcag aagagaggcc    960

agttccaagc aggggcatag aacagaacaa tctgcaaggg agttgggagc atataccgct   1020

gggttaagac agtgagtgag aaaaggctgg aaggcagaca gtgctgggca aaggagctgg   1080

agcttgatca ttgctgcata cgaaaatgga ggcatttaaa ctgggactga gatgggactg   1140

agtgattaaa ttgctaccag tgttagtttt aagagttgaa aagcttaata gtaaatttta   1200

ataagcccat gaacttgatt atggctacct ttattttaaa caaggagacc ttaatggaca   1260

gaatcaagaa acagctacgt gaatgggatg aaaatctaaa agatgattct cttccttcaa   1320

atccaatagg tatgaaaagt tagtttcctg cctggagcct gggatgtctt gctataaaaa   1380

atagcttttt catggatgcg atccaatcat atcttctagg ttttaagact gattaaaaca   1440

ttttaattct gaaaagcata atttcctttg agcagttgaa aaaaaatgag tattttaaaa   1500

ttaattgcaa taaaatcctc atattctgtg agcactccaa ttttagacaa gttttccata   1560

aaaagttcaa attgcaggaa gtggctgtca tccaaaaaca cttcctgtgt aaggactcct   1620

ttccctgttc ttcaaggtgc ctttaaaaga agtgagtcta gttccaggac ttgccttaat   1680

tatagatact ctctttatct gtttataagg tatagtttag ttatttttct agtctcttgg   1740

caaataactt ctaacatgga tttgagttca tgtttaacat aaaaggattt taccaaaaaa   1800

agtataagaa aagcaattaa atttagagct tctgaaaagt gtatctttga cagctggtat   1860

atttttgtat tgtttatact tgtataaaat gtgtaacctt aaagagaagg gtttatttca   1920

aaaggatatt atccgatttg taagttctct gatgcttatc tgactcctaa gtttaaaact   1980

tgaaaaacca tgtcttgaag atttttctta cagagtagct gcttgtcttc ctattgatga   2040

tgtattgaga attcagctcc ttaaaattgg cagtgctatc cagcgacttc gctgtgaatt   2100

agacattatg aataaagtga gtaaagtgaa tatgtttttg atgcccatgt tttattcagg   2160

ctggagaact aggatgctct gttggggcca atggagctct gtatagagtc cagtaatgta   2220

gtcatgcaat tcagatttca attgggatct tacaaacaaa ctcattgttt tgtgtttgtc   2280

aaatatgaat acatttatca acttagtgaa aaataacttg atttctgcat ggaaatatcc   2340

aaggttatat atcactattc ctttactcta gagaaggtca tttagtttta tgtaaatatg   2400

tggcagatct cagtttcagt gactttcgtg ctccatcttt aaaagtgttt ttgaatgctt   2460

ggaaggaaaa tgtgatattc agagagagca atatctttat aagtaagttt cttgatgatc   2520

tatgtgatta catgataaag tgaatgccag tttttcctac caataatttt tctctcaaat   2580

cttttagtgt acttcccttt gctgtaaaca atgtcaagaa acagaaataa caaccaaaaa   2640

tgaaatattc agtttatcct tatgtgggcc gatggcagct tatgtgaatc ctcatggata   2700

tgtgcatgag acacttactg tgtataaggc ttgcaacttg aatctgatag gccggccttc   2760

tacagaacac agctggtttc ctgggtatgc ctggactgtt gcccagtgta agatctgtgc   2820

aagccatatt ggatggaagt ttacggccac caaaaaagac atgtcacctc aaaaattttg   2880

gggcttaacg cgatctgctc tgttgcccac gatcccagac actgaagatg aaataagtcc   2940

agacaaagta atactttgct tgtaaacaga tgtgatagag ataaagttat ctaacaaatt   3000

ggttatattc taagatctgc tttggaaatt attgcctctg atacatacct aagtaaacat   3060

aacattaata cctaagtaaa cataacatta cttggagggt tgcagtttct aagtgaaact   3120

gtatttgaaa cttttaagta tactttagga aacaagcatg aacggcagtc tagaatacca   3180

gaaacatcta cttgggtagc ttggtgccat tatcctgtgg aatctgatat gtctggtagc   3240

atgtcattga tgggacatga agacatcttt ggaaatgatg agattatttc ctgtgttaaa   3300

aaaaaaaaaa atcttaaatt cctacaatgt gaaactgaaa ctaataattt gatcctgatg   3360

tatgggacag cgtatctgta ccagtgctct aaataacaaa agctagggtg acaagtacat   3420

gttccttttg gaaagaagca aggcaatgta tattaattat tctaaaaggg ctttgttcct   3480

ttccattttc tttaacttct ctgagatact gatttgtaaa ttttgaaaat tagttaaaat   3540

atgcagtttt ttgagcccac gaatagttgt catttccttt atgtgcctgt tagtaaaaag   3600

tagtattgtg tatttgctca gtatctgaac tataagccca tttatactgt tccatacaaa   3660

agctattttt caaaaattaa tttgaaccaa aactactact atagggaaaa gatgccaaaa   3720

catgtcccct cacccagact aaacttgata ctgtattatt ttgttcaatg taaattgaag   3780

aaaatctgta agtaagtaaa ccttaagtgt gaaactaaac atgttctttg ttcaaataat   3840

gtaaaatatc tactcataat tttaaagttc taaaaaggct gctttgccac ctacctcttt   3900

gcttatattc aagggtttag tgggtccttc cttccacatt tgtatgataa ctttcgtttt   3960

attggtagtc ctttgctact ttaaaactaa tcaggttaaa tgtttactca aatgtagtaa   4020

tagtatgagg ccaaaataca tgccttgaag gtggagtgaa atcagttgag tgtcacactg   4080

catatttatg taaatagagt aaatgaaaat tcaagaatac ttccaatcag gatatgcccc   4140

tgccttattt tttctaaggt ctacttttac tactttaata attttgggtt tgtgtg       4196


<210>  8976
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  8976

Met Ala Ala Tyr Val Asn Pro His Gly Tyr Val His Glu Thr Leu Thr 
1               5                   10                  15      


Val Tyr Lys Ala Cys Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu 
            20                  25                  30          


His Ser Trp Phe Pro Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile 
        35                  40                  45              


Cys Ala Ser His Ile Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met 
    50                  55                  60                  


Ser Pro Gln Lys Phe Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr 
65                  70                  75                  80  


Ile Pro Asp Thr Glu Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys 
                85                  90                  95      


Leu 
    


<210>  8977
<211>  2580
<212>  DNA
<213>  Homosapiens

<400>  8977
tcctttgcgg gtaaacagac atggccggcg aaggagatca gcaggacgct gcgcacaaca     60

tgggcaacca cctgccgctc ctgcctgcag agagtgagga agaagatgaa atggaagttg    120

aagaccagga tagtaaagaa gccaaaaaac caaacatcat aaattttgac accagtctgc    180

cgacatcaca tacataccta ggtgctgata tggaagaatt tcatggcagg actttgcacg    240

atgacgacag ctgtcaggtg attccagttc ttccacaagt gatgatgatc ctgattcccg    300

gacagacatt acctcttcag ctttttcacc ctcaagaagt cagtatggtg cggaatttaa    360

ttcagaaaga tagaaccttt gctgttcttg catacagcaa tgtacaggaa agggaagcac    420

agtttggaac aacagcagag atatatgcct atcgagaaga acaggatttt ggaattgaga    480

tagtgaaagt gaaagcaatt ggaagacaaa ggttcaaagt ccttgagcta agaacacagt    540

cagatggaat ccagcaagct aaagtgcaaa ttcttcccga atgtgtgttg ccttcaacca    600

tgtctgcagt tcaattagaa tccctcaata agtgccagat atttccttca aaacctgtct    660

caagagaaga ccaatgttca tataaatggt ggcagaaata ccagaagaga aagtttcatt    720

gtgcaaatct aacttcatgg cctcgctggc tgtattcctt atatgatgct gagaccttaa    780

tggacagaat caagaaacag ctacgtgaat gggatgaaaa tctaaaagat gattctcttc    840

cttcaaatcc aatagatttt tcttacagag tagctgcttg tcttcctatt gatgatgtat    900

tgagaattca gctccttaaa attggcagtg ctatccagcg acttcgctgt gaattagaca    960

ttatgaataa atgtacttcc ctttgctgta aacaatgtca agaaacagaa ataacaacca   1020

aaaatgaaat attcagttta tccttatgtg ggccgatggc agcttatgtg aatcctcatg   1080

gatatgtgca tgagacactt actgtgtata aggcttgcaa cttgaatctg ataggccggc   1140

cttctacaga acacagctgg tttcctgggt atgcctggac tgttgcccag tgtaagatct   1200

gtgcaagcca tattggatgg aagtttacgg ccaccaaaaa agacatgtca cctcaaaaat   1260

tttggggctt aacgcgatct gctctgttgc ccacgatccc agacactgaa gatgaaataa   1320

gtccagacaa agtaatactt tgcttgtaaa cagatgtgat agagataaag ttatctaaca   1380

aattggttat attctaagat ctgctttgga aattattgcc tctgatacat acctaagtaa   1440

acataacatt aatacctaag taaacataac attacttgga gggttgcagt ttctaagtga   1500

aactgtattt gaaactttta agtatacttt aggaaacaag catgaacggc agtctagaat   1560

accagaaaca tctacttggg tagcttggtg ccattatcct gtggaatctg atatgtctgg   1620

tagcatgtca ttgatgggac atgaagacat ctttggaaat gatgagatta tttcctgtgt   1680

taaaaaaaaa aaaaatctta aattcctaca atgtgaaact gaaactaata atttgatcct   1740

gatgtatggg acagcgtatc tgtaccagtg ctctaaataa caaaagctag ggtgacaagt   1800

acatgttcct tttggaaaga agcaaggcaa tgtatattaa ttattctaaa agggctttgt   1860

tcctttccat tttctttaac ttctctgaga tactgatttg taaattttga aaattagtta   1920

aaatatgcag ttttttgagc ccacgaatag ttgtcatttc ctttatgtgc ctgttagtaa   1980

aaagtagtat tgtgtatttg ctcagtatct gaactataag cccatttata ctgttccata   2040

caaaagctat ttttcaaaaa ttaatttgaa ccaaaactac tactataggg aaaagatgcc   2100

aaaacatgtc ccctcaccca gactaaactt gatactgtat tattttgttc aatgtaaatt   2160

gaagaaaatc tgtaagtaag taaaccttaa gtgtgaaact aaacatgttc tttgttcaaa   2220

taatgtaaaa tatctactca taattttaaa gttctaaaaa ggctgctttg ccacctacct   2280

ctttgcttat attcaagggt ttagtgggtc cttccttcca catttgtatg ataactttcg   2340

ttttattggt agtcctttgc tactttaaaa ctaatcaggt taaatgttta ctcaaatgta   2400

gtaatagtat gaggccaaaa tacatgcctt gaaggtggag tgaaatcagt tgagtgtcac   2460

actgcatatt tatgtaaata gagtaaatga aaattcaaga atacttccaa tcaggatatg   2520

cccctgcctt attttttcta aggtctactt ttactacttt aataattttg ggtttgtgtg   2580


<210>  8978
<211>  442
<212>  PRT
<213>  Homosapiens

<400>  8978

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu 
        275                 280                 285             


Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala 
    290                 295                 300                 


Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser 
305                 310                 315                 320 


Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu 
                325                 330                 335     


Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro 
            340                 345                 350         


His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu 
        355                 360                 365             


Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr 
    370                 375                 380                 


Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp 
385                 390                 395                 400 


Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly 
                405                 410                 415     


Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu 
            420                 425                 430         


Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440         


<210>  8979
<211>  1255
<212>  DNA
<213>  Homosapiens

<400>  8979
ataaatgtac ttccctttgc tgtaaacaat gtcaagaaac agaaataaca accaaaaatg     60

aaatattcag tttatcctta tgtgggccga tggcagctta tgtgaatcct catggatatg    120

tgcatgagac acttactgtg tataaggctt gcaacttgaa tctgataggc cggccttcta    180

cagaacacag ctggtttcct gggtatgcct ggactgttgc ccagtgtaag atctgtgcaa    240

gccatattgg atggaagttt acggccacca aaaaagacat gtcacctcaa aaattttggg    300

gcttaacgcg atctgctctg ttgcccacga tcccagacac tgaagatgaa ataagtccag    360

acaaagtaat actttgcttg taaacagatg tgatagagat aaagttatct aacaaattgg    420

ttatattcta agatctgctt tggaaattat tgcctctgat acatacctaa gtaaacataa    480

cattaatacc taagtaaaca taacattact tggagggttg cagtttctaa gtgaaactgt    540

atttgaaact tttaagtata ctttaggaaa caagcatgaa cggcagtcta gaataccaga    600

aacatctact tgggtagctt ggtgccatta tcctgtggaa tctgatatgt ctggtagcat    660

gtcattgatg ggacatgaag acatctttgg aaatgatgag attatttcct gtgttaaaaa    720

aaaaaaaaat cttaaattcc tacaatgtga aactgaaact aataatttga tcctgatgta    780

tgggacagcg tatctgtacc agtgctctaa ataacaaaag ctagggtgac aagtacatgt    840

tccttttgga aagaagcaag gcaatgtata ttaattattc taaaagggct ttgttccttt    900

ccattttctt taacttctct gagatactga tttgtaaatt ttgaaaatta gttaaaatat    960

gcagtttttt gagcccacga atagttgtca tttcctttat gtgcctgtta gtaaaaagta   1020

gtattgtgta tttgctcagt atctgaacta taagcccatt tatactgttc catacaaaag   1080

ctatttttca aaaattaatt tgaaccaaaa ctactactat agggaaaaga tgccaaaaca   1140

tgtcccctca cccagactaa acttgatact gtattatttt gttcaatgta aattgaagaa   1200

aatctgtaag taagtaaacc ttaagtgtga aactaaacat gttctttgtt caaat        1255


<210>  8980
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  8980

Met Ala Ala Tyr Val Asn Pro His Gly Tyr Val His Glu Thr Leu Thr 
1               5                   10                  15      


Val Tyr Lys Ala Cys Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu 
            20                  25                  30          


His Ser Trp Phe Pro Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile 
        35                  40                  45              


Cys Ala Ser His Ile Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met 
    50                  55                  60                  


Ser Pro Gln Lys Phe Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr 
65                  70                  75                  80  


Ile Pro Asp Thr Glu Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys 
                85                  90                  95      


Leu 
    


<210>  8981
<211>  2058
<212>  DNA
<213>  Homosapiens

<400>  8981
ctcttccttc aaatccaata ggtatgaaaa gttagtttcc tgcctggagc ctgggatgtc     60

ttgctataaa aaatagcttt ttcatggatg cgatccaatc atatcttcta ggttttaaga    120

ctgattaaaa cattttaatt ctgaaaagca taatttcctt tgagcagttg aaaaaaaatg    180

agtattttaa aattaattgc aataaaatcc tcatattctg tgagcactcc aattttagac    240

aagttttcca taaaaagttc aaattgcagg aagtggctgt catccaaaaa cacttcctgt    300

gtaaggactc ctttccctgt tcttcaaggt gcctttaaaa gaagtgagtc tagttccagg    360

acttgcctta attatagata ctctctttat ctgtttataa ggtatagttt agttattttt    420

ctagtctctt ggcaaataac ttctaacatg gatttgagtt catgtttaac ataaaaggat    480

tttaccaaaa aaagtataag aaaagcaatt aaatttagag cttctgaaaa gtgtatcttt    540

gacagctggt atatttttgt attgtttata cttgtataaa atgtgtaacc ttaaagagaa    600

gggtttattt caaaaggata ttatccgatt tgtaagttct ctgatgctta tctgactcct    660

aagtttaaaa cttgaaaaac catgtcttga agatttttct tacagagtag ctgcttgtct    720

tcctattgat gatgtattga gaattcagct ccttaaaatt ggcagtgcta tccagcgact    780

tcgctgtgaa ttagacatta tgaataaatg tacttccctt tgctgtaaac aatgtcaaga    840

aacagaaata acaaccaaaa atgaaatatt cagtttatcc ttatgtgggc cgatggcagc    900

ttatgtgaat cctcatggat atgtgcatga gacacttact gtgtataagg cttgcaactt    960

gaatctgata ggccggcctt ctacagaaca cagctggttt cctgggtatg cctggactgt   1020

tgcccagtgt aagatctgtg caagccatat tggatggaag tttacggcca ccaaaaaaga   1080

catgtcacct caaaaatttt ggggcttaac gcgatctgct ctgttgccca cgatcccaga   1140

cactgaagat gaaataagtc cagacaaagt aatactttgc ttgtaaacag atgtgataga   1200

gataaagtta tctaacaaat tggttatatt ctaagatctg ctttggaaat tattgcctct   1260

gatacatacc taagtaaaca taacattaat acctaagtaa acataacatt acttggaggg   1320

ttgcagtttc taagtgaaac tgtatttgaa acttttaagt atactttagg aaacaagcat   1380

gaacggcagt ctagaatacc agaaacatct acttgggtag cttggtgcca ttatcctgtg   1440

gaatctgata tgtctggtag catgtcattg atgggacatg aagacatctt tggaaatgat   1500

gagattattt cctgtgttaa aaaaaaaaaa aatcttaaat tcctacaatg tgaaactgaa   1560

actaataatt tgatcctgat gtatgggaca gcgtatctgt accagtgctc taaataacaa   1620

aagctagggt gacaagtaca tgttcctttt ggaaagaagc aaggcaatgt atattaatta   1680

ttctaaaagg gctttgttcc tttccatttt ctttaacttc tctgagatac tgatttgtaa   1740

attttgaaaa ttagttaaaa tatgcagttt tttgagccca cgaatagttg tcatttcctt   1800

tatgtgcctg ttagtaaaaa gtagtattgt gtatttgctc agtatctgaa ctataagccc   1860

atttatactg ttccatacaa aagctatttt tcaaaaatta atttgaacca aaactactac   1920

tatagggaaa agatgccaaa acatgtcccc tcacccagac taaacttgat actgtattat   1980

tttgttcaat gtaaattgaa gaaaatctgt aagtaagtaa accttaagtg tgaaactaaa   2040

catgttcttt gttcaaat                                                 2058


<210>  8982
<211>  128
<212>  PRT
<213>  Homosapiens

<400>  8982

Met Asn Lys Cys Thr Ser Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu 
1               5                   10                  15      


Ile Thr Thr Lys Asn Glu Ile Phe Ser Leu Ser Leu Cys Gly Pro Met 
            20                  25                  30          


Ala Ala Tyr Val Asn Pro His Gly Tyr Val His Glu Thr Leu Thr Val 
        35                  40                  45              


Tyr Lys Ala Cys Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His 
    50                  55                  60                  


Ser Trp Phe Pro Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys 
65                  70                  75                  80  


Ala Ser His Ile Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser 
                85                  90                  95      


Pro Gln Lys Phe Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile 
            100                 105                 110         


Pro Asp Thr Glu Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        115                 120                 125             


<210>  8983
<211>  1590
<212>  DNA
<213>  Homosapiens

<400>  8983
atggaggcat ttaaactggg actgagatgg gactgagtga ttaaattgct accagtgtta     60

gttttaagag ttgaaaagct taatagtaaa ttttaataag cccatgaact tgattatggc    120

tacctttatt ttaaacaagg agaccttaat ggacagaatc aagaaacagc tacgtgaatg    180

ggatgaaaat ctaaaagatg attctcttcc ttcaaatcca atagattttt cttacagagt    240

agctgcttgt cttcctattg atgatgtatt gagaattcag ctccttaaaa ttggcagtgc    300

tatccagcga cttcgctgtg aattagacat tatgaataaa tgtacttccc tttgctgtaa    360

acaatgtcaa gaaacagaaa taacaaccaa aaatgaaata ttcagtttat ccttatgtgg    420

gccgatggca gcttatgtga atcctcatgg atatgtgcat gagacactta ctgtgtataa    480

ggcttgcaac ttgaatctga taggccggcc ttctacagaa cacagctggt ttcctgggta    540

tgcctggact gttgcccagt gtaagatctg tgcaagccat attggatgga agtttacggc    600

caccaaaaaa gacatgtcac ctcaaaaatt ttggggctta acgcgatctg ctctgttgcc    660

cacgatccca gacactgaag atgaaataag tccagacaaa gtaatacttt gcttgtaaac    720

agatgtgata gagataaagt tatctaacaa attggttata ttctaagatc tgctttggaa    780

attattgcct ctgatacata cctaagtaaa cataacatta atacctaagt aaacataaca    840

ttacttggag ggttgcagtt tctaagtgaa actgtatttg aaacttttaa gtatacttta    900

ggaaacaagc atgaacggca gtctagaata ccagaaacat ctacttgggt agcttggtgc    960

cattatcctg tggaatctga tatgtctggt agcatgtcat tgatgggaca tgaagacatc   1020

tttggaaatg atgagattat ttcctgtgtt aaaaaaaaaa aaaatcttaa attcctacaa   1080

tgtgaaactg aaactaataa tttgatcctg atgtatggga cagcgtatct gtaccagtgc   1140

tctaaataac aaaagctagg gtgacaagta catgttcctt ttggaaagaa gcaaggcaat   1200

gtatattaat tattctaaaa gggctttgtt cctttccatt ttctttaact tctctgagat   1260

actgatttgt aaattttgaa aattagttaa aatatgcagt tttttgagcc cacgaatagt   1320

tgtcatttcc tttatgtgcc tgttagtaaa aagtagtatt gtgtatttgc tcagtatctg   1380

aactataagc ccatttatac tgttccatac aaaagctatt tttcaaaaat taatttgaac   1440

caaaactact actataggga aaagatgcca aaacatgtcc cctcacccag actaaacttg   1500

atactgtatt attttgttca atgtaaattg aagaaaatct gtaagtaagt aaaccttaag   1560

tgtgaaacta aacatgttct ttgttcaaat                                    1590


<210>  8984
<211>  204
<212>  PRT
<213>  Homosapiens

<400>  8984

Met Asn Leu Ile Met Ala Thr Phe Ile Leu Asn Lys Glu Thr Leu Met 
1               5                   10                  15      


Asp Arg Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp 
            20                  25                  30          


Asp Ser Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala 
        35                  40                  45              


Cys Leu Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly 
    50                  55                  60                  


Ser Ala Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys 
65                  70                  75                  80  


Thr Ser Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys 
                85                  90                  95      


Asn Glu Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val 
            100                 105                 110         


Asn Pro His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys 
        115                 120                 125             


Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro 
    130                 135                 140                 


Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile 
145                 150                 155                 160 


Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe 
                165                 170                 175     


Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu 
            180                 185                 190         


Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        195                 200                 


<210>  8985
<211>  4546
<212>  DNA
<213>  Homosapiens

<400>  8985
aggaacttca tcatgaagtc tcaagtaaac gaacatttta tctttcttgg gattctatca     60

cttcttaatg tttgccctta tagtgattca gctgattctc atttaaagtt tttacacaaa    120

aacagtttgg attatatctt gaggttttca cttcagatac tggacaagta attagtataa    180

aggcaactaa catggtcata atagaagtat ggtgtttact ctcaacattt atcttcccaa    240

agttgtcttc agcattgaaa ttttaatgtt tgaccttttt aaataggaat gaagattcta    300

gttacaatat atatttgaag gatataggaa gcatgatttc acacttcata gatagtcacg    360

tcatgggatt atctacaaaa ttttttatct ttttaaaatt agatgttttc ctaggccaaa    420

atcatttttc agatgttgct cattccagca ttagaatctt tattctgtgg ggttttttaa    480

gtgccttttt gttttgtttt cagagaaagt ttcattgtgc aaatctaact tcatggcctc    540

gctggctgta ttccttatat gatgctgtaa gtaacttacc ttaaatttac tttatatatg    600

gtaggccatg tcataattaa gggtcattaa aaaacaaagg tttagttttt ccagtttcta    660

gtgccttata acttaagata tcgttaagag tggtggctca cacctgtaat cccagcactt    720

tgggaggcca aggcaggggg attgcttgaa gccaggcatt caagaccagc ctgggcaaca    780

tggtgaaacc ccatctctac aaatacaaaa attagccagg tttggtggca tgtggctgta    840

gtcccagctg cttgagaggc tgaggtggaa ggattgattg agcctgggag gtcaaggctg    900

ccgtgagctg agattgtgtc actgtactcc agcctggaca acagagcaag actgtctcaa    960

aagggaaaaa aaaaggtatc acaagactct ttagagtttt attaagcatg tgaaattttg   1020

ttgggttggg tgatagttac atttagaaca ttaaagcatc catattttac tgttttggtt   1080

tttctctaaa caagtatatt aacttacgtc tcttgatcat tagtctatta attaatgcat   1140

ccaggagggt ttttgctcct taaagtttaa cactaggcat tgccacattt tgcaaaacta   1200

agggacagtg ctgaaatggt ttaaagaatc tggatttcag atcagagact gacttcagag   1260

tctgatttct gtcacttact ctgtgggcct ggagcaaatt acttctccaa ggacctatga   1320

aatggatata atggtagcta ttgtacctgg tgtgcatagc gggcattcaa taaatgctag   1380

ccatttccct taatgaatca ctgcccacaa atctggagtc ctgggaaaac tcaacaacat   1440

gcacgacact aaaggaaact gcagttgatc tccgctcttt agcagctttt cagcaattac   1500

aaagacacaa tatatgagtt tttgcatgtt ttgcatatgc ttgtgaaaat tatgtagtaa   1560

ataggtgcca agtaaggtat gtagatagca agtgctagtg caatttatag gtgccataat   1620

ccctatggac tgggtcagaa atggcctaat agaaggcaga agagaggcca gttccaagca   1680

ggggcataga acagaacaat ctgcaaggga gttgggagca tataccgctg ggttaagaca   1740

gtgagtgaga aaaggctgga aggcagacag tgctgggcaa aggagctgga gcttgatcat   1800

tgctgcatac gaaaatggag gcatttaaac tgggactgag atgggactga gtgattaaat   1860

tgctaccagt gttagtttta agagttgaaa agcttaatag taaattttaa taagcccatg   1920

aacttgatta tggctacctt tattttaaac aaggagacct taatggacag aatcaagaaa   1980

cagctacgtg aatgggatga aaatctaaaa gatgattctc ttccttcaaa tccaataggt   2040

atgaaaagtt agtttcctgc ctggagcctg ggatgtcttg ctataaaaaa tagctttttc   2100

atggatgcga tccaatcata tcttctaggt tttaagactg attaaaacat tttaattctg   2160

aaaagcataa tttcctttga gcagttgaaa aaaaatgagt attttaaaat taattgcaat   2220

aaaatcctca tattctgtga gcactccaat tttagacaag ttttccataa aaagttcaaa   2280

ttgcaggaag tggctgtcat ccaaaaacac ttcctgtgta aggactcctt tccctgttct   2340

tcaaggtgcc tttaaaagaa gtgagtctag ttccaggact tgccttaatt atagatactc   2400

tctttatctg tttataaggt atagtttagt tatttttcta gtctcttggc aaataacttc   2460

taacatggat ttgagttcat gtttaacata aaaggatttt accaaaaaaa gtataagaaa   2520

agcaattaaa tttagagctt ctgaaaagtg tatctttgac agctggtata tttttgtatt   2580

gtttatactt gtataaaatg tgtaacctta aagagaaggg tttatttcaa aaggatatta   2640

tccgatttgt aagttctctg atgcttatct gactcctaag tttaaaactt gaaaaaccat   2700

gtcttgaaga tttttcttac agagtagctg cttgtcttcc tattgatgat gtattgagaa   2760

ttcagctcct taaaattggc agtgctatcc agcgacttcg ctgtgaatta gacattatga   2820

ataaagtgag taaagtgaat atgtttttga tgcccatgtt ttattcaggc tggagaacta   2880

ggatgctctg ttggggccaa tggagctctg tatagagtcc agtaatgtag tcatgcaatt   2940

cagatttcaa ttgggatctt acaaacaaac tcattgtttt gtgtttgtca aatatgaata   3000

catttatcaa cttagtgaaa aataacttga tttctgcatg gaaatatcca aggttatata   3060

tcactattcc tttactctag agaaggtcat ttagttttat gtaaatatgt ggcagatctc   3120

agtttcagtg actttcgtgc tccatcttta aaagtgtttt tgaatgcttg gaaggaaaat   3180

gtgatattca gagagagcaa tatctttata agtaagtttc ttgatgatct atgtgattac   3240

atgataaagt gaatgccagt ttttcctacc aataattttt ctctcaaatc ttttagtgta   3300

cttccctttg ctgtaaacaa tgtcaagaaa cagaaataac aaccaaaaat gaaatattca   3360

gtttatcctt atgtgggccg atggcagctt atgtgaatcc tcatggatat gtgcatgaga   3420

cacttactgt gtataaggct tgcaacttga atctgatagg ccggccttct acagaacaca   3480

gctggtttcc tgggtatgcc tggactgttg cccagtgtaa gatctgtgca agccatattg   3540

gatggaagtt tacggccacc aaaaaagaca tgtcacctca aaaattttgg ggcttaacgc   3600

gatctgctct gttgcccacg atcccagaca ctgaagatga aataagtcca gacaaagtaa   3660

tactttgctt gtaaacagat gtgatagaga taaagttatc taacaaattg gttatattct   3720

aagatctgct ttggaaatta ttgcctctga tacataccta agtaaacata acattaatac   3780

ctaagtaaac ataacattac ttggagggtt gcagtttcta agtgaaactg tatttgaaac   3840

ttttaagtat actttaggaa acaagcatga acggcagtct agaataccag aaacatctac   3900

ttgggtagct tggtgccatt atcctgtgga atctgatatg tctggtagca tgtcattgat   3960

gggacatgaa gacatctttg gaaatgatga gattatttcc tgtgttaaaa aaaaaaaaaa   4020

tcttaaattc ctacaatgtg aaactgaaac taataatttg atcctgatgt atgggacagc   4080

gtatctgtac cagtgctcta aataacaaaa gctagggtga caagtacatg ttccttttgg   4140

aaagaagcaa ggcaatgtat attaattatt ctaaaagggc tttgttcctt tccattttct   4200

ttaacttctc tgagatactg atttgtaaat tttgaaaatt agttaaaata tgcagttttt   4260

tgagcccacg aatagttgtc atttccttta tgtgcctgtt agtaaaaagt agtattgtgt   4320

atttgctcag tatctgaact ataagcccat ttatactgtt ccatacaaaa gctatttttc   4380

aaaaattaat ttgaaccaaa actactacta tagggaaaag atgccaaaac atgtcccctc   4440

acccagacta aacttgatac tgtattattt tgttcaatgt aaattgaaga aaatctgtaa   4500

gtaagtaaac cttaagtgtg aaactaaaca tgttctttgt tcaaat                  4546


<210>  8986
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  8986

Met Ala Ala Tyr Val Asn Pro His Gly Tyr Val His Glu Thr Leu Thr 
1               5                   10                  15      


Val Tyr Lys Ala Cys Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu 
            20                  25                  30          


His Ser Trp Phe Pro Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile 
        35                  40                  45              


Cys Ala Ser His Ile Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met 
    50                  55                  60                  


Ser Pro Gln Lys Phe Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr 
65                  70                  75                  80  


Ile Pro Asp Thr Glu Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys 
                85                  90                  95      


Leu 
    


<210>  8987
<211>  2221
<212>  DNA
<213>  Homosapiens

<400>  8987
tcctttgcgg gtaaacagac atggccggcg aaggagatca gcaggacgct gcgcacaaca     60

tgggcaacca cctgccgctc ctgcctgcag agagtgagga agaagatgaa atggaagttg    120

aagaccagga tagtaaagaa gccaaaaaac caaacatcat aaattttgac accagtctgc    180

cgacatcaca tacataccta ggtgctgata tggaagaatt tcatggcagg actttgcacg    240

atgacgacag ctgtcaggtg attccagttc ttccacaagt gatgatgatc ctgattcccg    300

gacagacatt acctcttcag ctttttcacc ctcaagaagt cagtatggtg cggaatttaa    360

ttcagaaaga tagaaccttt gctgttcttg catacagcaa tgtacaggaa agggaagcac    420

agtttggaac aacagcagag atatatgcct atcgagaaga acaggatttt ggaattgaga    480

tagtgaaagt gaaagcaatt ggaagacaaa ggttcaaagt ccttgagcta agaacacagt    540

cagatggaat ccagcaagct aaagtgcaaa ttcttcccga atgtgtgttg ccttcaacca    600

tgtctgcagt tcaattagaa tccctcaata agtgccagat atttccttca aaacctgtct    660

caagagaaga ccaatgttca tataaatggt ggcagaaata ccagaagaga aagtttcatt    720

gtgcaaatct aacttcatgg cctcgctggc tgtattcctt atatgatgct gagaccttaa    780

tggacagaat caagaaacag ctacgtgaat gggatgaaaa tctaaaagat gattctcttc    840

cttcaaatcc aatagatttt tcttacagag tagctgcttg tcttcctatt gatgatgtat    900

tgagaattca gctccttaaa attggcagtg ctatccagcg acttcgctgt gaattagaca    960

ttatgaataa atgtacttcc ctttgctgta aacaatgtca agaaacagaa ataacaacca   1020

aaaatgaaat attcagttta tccttatgtg ggccgatggc agcttatgtg aatcctcatg   1080

gatatgtgca tgagacactt actgtgtata aggcttgcaa cttgaatctg ataggccggc   1140

cttctacaga acacagctgg tttcctgggt atgcctggac tgttgcccag tgtaagatct   1200

gtgcaagcca tattggatgg aagtttacgg ccaccaaaaa agacatgtca cctcaaaaat   1260

tttggggctt aacgcgatct gctctgttgc ccacgatccc agacactgaa gatgaaataa   1320

gtccagacaa agtaatactt tgcttgtaaa cagatgtgat agagataaag ttatctaaca   1380

aattggttat attctaagat ctgctttgga aattattgcc tctgatacat acctaagtaa   1440

acataacatt aatacctaag taaacataac attacttgga gggttgcagt ttctaagtga   1500

aactgtattt gaaactttta agtatacttt aggaaacaag catgaacggc agtctagaat   1560

accagaaaca tctacttggg tagcttggtg ccattatcct gtggaatctg atatgtctgg   1620

tagcatgtca ttgatgggac atgaagacat ctttggaaat gatgagatta tttcctgtgt   1680

taaaaaaaaa aaaaatctta aattcctaca atgtgaaact gaaactaata atttgatcct   1740

gatgtatggg acagcgtatc tgtaccagtg ctctaaataa caaaagctag ggtgacaagt   1800

acatgttcct tttggaaaga agcaaggcaa tgtatattaa ttattctaaa agggctttgt   1860

tcctttccat tttctttaac ttctctgaga tactgatttg taaattttga aaattagtta   1920

aaatatgcag ttttttgagc ccacgaatag ttgtcatttc ctttatgtgc ctgttagtaa   1980

aaagtagtat tgtgtatttg ctcagtatct gaactataag cccatttata ctgttccata   2040

caaaagctat ttttcaaaaa ttaatttgaa ccaaaactac tactataggg aaaagatgcc   2100

aaaacatgtc ccctcaccca gactaaactt gatactgtat tattttgttc aatgtaaatt   2160

gaagaaaatc tgtaagtaag taaaccttaa gtgtgaaact aaacatgttc tttgttcaaa   2220

t                                                                   2221


<210>  8988
<211>  442
<212>  PRT
<213>  Homosapiens

<400>  8988

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu 
        275                 280                 285             


Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala 
    290                 295                 300                 


Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser 
305                 310                 315                 320 


Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu 
                325                 330                 335     


Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro 
            340                 345                 350         


His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu 
        355                 360                 365             


Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr 
    370                 375                 380                 


Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp 
385                 390                 395                 400 


Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly 
                405                 410                 415     


Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu 
            420                 425                 430         


Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440         


<210>  8989
<211>  1681
<212>  DNA
<213>  Homosapiens

<400>  8989
tcctttgcgg gtaaacagac atggccggcg aaggagatca gcaggacgct gcgcacaaca     60

tgggcaacca cctgccgctc ctgcctgcag agagtgagga agaagatgaa atggaagttg    120

aagaccagga tagtaaagaa gccaaaaaac caaacatcat aaattttgac accagtctgc    180

cgacatcaca tacataccta ggtgctgata tggaagaatt tcatggcagg actttgcacg    240

atgacgacag ctgtcaggtg attccagttc ttccacaagt gatgatgatc ctgattcccg    300

gacagacatt acctcttcag ctttttcacc ctcaagaagt cagtatggtg cggaatttaa    360

ttcagaaaga tagaaccttt gctgttcttg catacagcaa tgtacaggaa agggaagcac    420

agtttggaac aacagcagag atatatgcct atcgagaaga acaggatttt ggaattgaga    480

tagtgaaagt gaaagcaatt ggaagacaaa ggttcaaagt ccttgagcta agaacacagt    540

cagatggaat ccagcaagct aaagtgcaaa ttcttcccga atgtgtgttg ccttcaacca    600

tgtctgcagt tcaattagaa tccctcaata agtgccagat atttccttca aaacctgtct    660

caagagaaga ccaatgttca tataaatggt ggcagaaata ccagaagaga aagtttcatt    720

gtgcaaatct aacttcatgg cctcgctggc tgtattcctt atatgatgct gagaccttaa    780

tggacagaat caagaaacag ctacgtgaat gggatgaaaa tctaaaagat gattctcttc    840

cttcaaatcc aatagatttt tcttacagag tagctgcttg tcttcctatt gatgatgtat    900

tgagaattca gctccttaaa attggcagtg ctatccagcg acttcgctgt gaattagaca    960

ttatgaataa atgtacttcc ctttgctgta aacaatgtca agaaacagaa ataacaacca   1020

aaaatgaaat attcagttta tccttatgtg ggccgatggc agcttatgtg aatcctcatg   1080

gatatgtgca tgagacactt actgtgtata aggcttgcaa cttgaatctg ataggccggc   1140

cttctacaga acacagctgg tttcctgggt atgcctggac tgttgcccag tgtaagatct   1200

gtgcaagcca tattggatgg aagtttacgg ccaccaaaaa agacatgtca cctcaaaaat   1260

tttggggctt aacgcgatct gctctgttgc ccacgatccc agacactgaa gatgaaataa   1320

gtccagacaa agtaatactt tgcttgtaaa cagatgtgat agagataaag ttatctaaca   1380

aattggttat attctaagat ctgctttgga aattattgcc tctgatacat acctaagtaa   1440

acataacatt aatacctaag taaacataac attacttgga gggttgcagt ttctaagtga   1500

aactgtattt gaaactttta agtatacttt aggaaacaag catgaacggc agtctagaat   1560

accagaaaca tctacttggg tagcttggtg ccattatcct gtggaatctg atatgtctgg   1620

tagcatgtca ttgatgggac atgaagacat ctttggaaat gatgagatta tttcctgtgt   1680

t                                                                   1681


<210>  8990
<211>  442
<212>  PRT
<213>  Homosapiens

<400>  8990

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu 
        275                 280                 285             


Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala 
    290                 295                 300                 


Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser 
305                 310                 315                 320 


Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu 
                325                 330                 335     


Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro 
            340                 345                 350         


His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu 
        355                 360                 365             


Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr 
    370                 375                 380                 


Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp 
385                 390                 395                 400 


Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly 
                405                 410                 415     


Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu 
            420                 425                 430         


Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440         


<210>  8991
<211>  429
<212>  DNA
<213>  Homosapiens

<400>  8991
ataaatgtac ttccctttgc tgtaaacaat gtcaagaaac agaaataaca accaaaaatg     60

aaatattcag tttatcctta tgtgggccga tggcagctta tgtgaatcct catggatatg    120

tgcatgagac acttactgtg tataaggctt gcaacttgaa tctgataggc cggccttcta    180

cagaacacag ctggtttcct gggtatgcct ggactgttgc ccagtgtaag atctgtgcaa    240

gccatattgg atggaagttt acggccacca aaaaagacat gtcacctcaa aaattttggg    300

gcttaacgcg atctgctctg ttgcccacga tcccagacac tgaagatgaa ataagtccag    360

acaaagtaat actttgcttg taaacagatg tgatagagat aaagttatct aacaaattgg    420

ttatattct                                                            429


<210>  8992
<211>  97
<212>  PRT
<213>  Homosapiens

<400>  8992

Met Ala Ala Tyr Val Asn Pro His Gly Tyr Val His Glu Thr Leu Thr 
1               5                   10                  15      


Val Tyr Lys Ala Cys Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu 
            20                  25                  30          


His Ser Trp Phe Pro Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile 
        35                  40                  45              


Cys Ala Ser His Ile Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met 
    50                  55                  60                  


Ser Pro Gln Lys Phe Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr 
65                  70                  75                  80  


Ile Pro Asp Thr Glu Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys 
                85                  90                  95      


Leu 
    


<210>  8993
<211>  764
<212>  DNA
<213>  Homosapiens

<400>  8993
atggaggcat ttaaactggg actgagatgg gactgagtga ttaaattgct accagtgtta     60

gttttaagag ttgaaaagct taatagtaaa ttttaataag cccatgaact tgattatggc    120

tacctttatt ttaaacaagg agaccttaat ggacagaatc aagaaacagc tacgtgaatg    180

ggatgaaaat ctaaaagatg attctcttcc ttcaaatcca atagattttt cttacagagt    240

agctgcttgt cttcctattg atgatgtatt gagaattcag ctccttaaaa ttggcagtgc    300

tatccagcga cttcgctgtg aattagacat tatgaataaa tgtacttccc tttgctgtaa    360

acaatgtcaa gaaacagaaa taacaaccaa aaatgaaata ttcagtttat ccttatgtgg    420

gccgatggca gcttatgtga atcctcatgg atatgtgcat gagacactta ctgtgtataa    480

ggcttgcaac ttgaatctga taggccggcc ttctacagaa cacagctggt ttcctgggta    540

tgcctggact gttgcccagt gtaagatctg tgcaagccat attggatgga agtttacggc    600

caccaaaaaa gacatgtcac ctcaaaaatt ttggggctta acgcgatctg ctctgttgcc    660

cacgatccca gacactgaag atgaaataag tccagacaaa gtaatacttt gcttgtaaac    720

agatgtgata gagataaagt tatctaacaa attggttata ttct                     764


<210>  8994
<211>  204
<212>  PRT
<213>  Homosapiens

<400>  8994

Met Asn Leu Ile Met Ala Thr Phe Ile Leu Asn Lys Glu Thr Leu Met 
1               5                   10                  15      


Asp Arg Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp 
            20                  25                  30          


Asp Ser Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala 
        35                  40                  45              


Cys Leu Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly 
    50                  55                  60                  


Ser Ala Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys 
65                  70                  75                  80  


Thr Ser Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys 
                85                  90                  95      


Asn Glu Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val 
            100                 105                 110         


Asn Pro His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys 
        115                 120                 125             


Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro 
    130                 135                 140                 


Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile 
145                 150                 155                 160 


Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe 
                165                 170                 175     


Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu 
            180                 185                 190         


Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        195                 200                 


<210>  8995
<211>  999
<212>  DNA
<213>  Homosapiens

<400>  8995
tcctttgcgg gtaaacagac atggccggcg aaggagatca gcaggacgct gcgcacaaca     60

tgggcaacca cctgccgctc ctgcctgcag agagtgagga agaagatgaa atggaagttg    120

aagaccagga tagtaaagaa gccaaaaaac caaacatcat aaattttgac accagtctgc    180

cgacatcaca tacataccta ggtgctgata tggaagaatt tcatggcagg actttgcacg    240

atgacgacag ctgtcaggtg attccagttc ttccacaagt gatgatgatc ctgattcccg    300

gacagacatt acctcttcag ctttttcacc ctcaagaagt cagtatggtg cggaatttaa    360

ttcagaaaga tagaaccttt gctgttcttg catacagcaa tgtacaggaa agggaagcac    420

agtttggaac aacagcagag atatatgcct atcgagaaga acaggatttt ggaattgaga    480

tagtgaaagt gaaagcaatt ggaagacaaa ggttcaaagt ccttgagcta agaacacagt    540

cagatggaat ccagcaagct aaagtgcaaa ttcttcccga atgtgtgttg ccttcaacca    600

tgtctgcagt tcaattagaa tccctcaata agtgccagat atttccttca aaacctgtct    660

caagagaaga ccaatgttca tataaatggt ggcagaaata ccagaaggtg agaaactaat    720

tttttatgca tcttcaaaaa atgaagacag gttgtttttt ttcctgtttt aagaaagaaa    780

cacaactttc atgattcatt acccagccac cttgtatggc aatattccag ctacatttga    840

tcctctaaaa attgcacagg cagctacttt atgtaaaagc agtttacaaa agcaataaaa    900

tgtcacacag ctgtaaggta tccttgttat tatgcttatc agctatatta atcgcttttg    960

atttttaatt ccatgggaaa tgcttattaa actatgatc                           999


<210>  8996
<211>  232
<212>  PRT
<213>  Homosapiens

<400>  8996

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Val Arg Asn 
225                 230         


<210>  8997
<211>  1018
<212>  DNA
<213>  Homosapiens

<400>  8997
tcctttgcgg gtaaacagac atggccggcg aaggagatca gcaggacgct gcgcacaaca     60

tgggcaacca cctgccgctc ctgcctgcag agagtgagga agaagatgaa atggaagttg    120

aagaccagga tagtaaagaa gccaaaaaac caaacatcat aaattttgac accagtctgc    180

cgacatcaca tacataccta ggtgctgata tggaagaatt tcatggcagg actttgcacg    240

atgacgacag ctgtcaggtg attccagttc ttccacaagt gatgatgatc ctgattcccg    300

gacagacatt acctcttcag ctttttcacc ctcaagaagt cagtatggtg cggaatttaa    360

ttcagaaaga tagaaccttt gctgttcttg catacagcaa tgtacaggaa agggaagcac    420

agtttggaac aacagcagag atatatgcct atcgagaaga acaggatttt ggaattgaga    480

tagtgaaagt gaaagcaatt ggaagacaaa ggttcaaagt ccttgagcta agaacacagt    540

cagatgggta tagcccagtg gtttccaacc ttgctatgca tcagaatcac ctgggaagct    600

tttaaaacta tagaagcttg agttccaacc tcatctccca tctccagaga gtgatgaggc    660

tgcagcatct tttaaaaatg attttcaggt gattctaatg tctctccagg tttgagaaca    720

atcatgtaaa tccaaaggga agtgttgttt gggatttggc ttctttagga ttgaaggcct    780

ctcggagcat aagaggatag ggagaccaga ggcttgtgag ctgttcgtgt gctcaccagg    840

acagctgtgg tttttgtagc attgctatga tgtttgaaag ccacactggt tacatctgcc    900

tactgctcca gctgagctat aaaagccatt tatatttcgt gtccctctcc agtgtgaatt    960

ttatatcacc cagaaatgct atttacataa taaatgatca ataaatactt gtagtcta     1018


<210>  8998
<211>  194
<212>  PRT
<213>  Homosapiens

<400>  8998

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Tyr Ser Pro Val Val Ser Asn Leu Ala Met His Gln Asn His Leu Gly 
            180                 185                 190         


Ser Phe 
        


<210>  8999
<211>  326
<212>  DNA
<213>  Homosapiens

<400>  8999
agacatggcc ggcgaaggag atcagcagga cgctgcgcac aacatgggca accacctgcc     60

gctcctgcct gcagagagtg aggaagaaga tgaaatggaa gttgaagacc aggatagtaa    120

agaagcctag gtgctgatat ggaagaattt catggcagga ctttgcacga tgacgacagc    180

tgtcaggtga ttccagttct tccacaagtg atgatgatcc tgattcccgg acagacatta    240

cctcttcagc tttttcaccc tcaagaagtc agtatggtgc ggaatttaat tcagaaagat    300

agaacctttg ctgttcttgc atacag                                         326


<210>  9000
<211>  41
<212>  PRT
<213>  Homosapiens

<400>  9000

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala 
        35                  40      


<210>  9001
<211>  3159
<212>  DNA
<213>  Homosapiens

<400>  9001
cgggtcacat ggcccgcggg acaacatggc tgcgcccgca ctagggctgg tgtgtggacg     60

ttgccctgag ctgggtctcg tcctcttgct gctgctgctc tcgctgctgt gtggagcggc    120

agggagccag gaggccggga ccggtgcggg cgcggggtcc cttgcgggtt cttgcggctg    180

cggcacgccc cagcggcctg gcgcccatgg cagttcggca gccgctcacc gatactcgcg    240

ggaggctaac gctccgggcc ccgtacccgg agagcggcaa ctcgcgcact caaagatggt    300

ccccatccct gctggagtat ttacaatggg cacagatgat cctcagataa agcaggatgg    360

ggaagcacct gcgaggagag ttactattga tgccttttac atggatgcct atgaagtcag    420

taatactgaa tttgagaagt ttgtgaactc aactggctat ttgacagagg ctgagaagtt    480

tggcgactcc tttgtctttg aaggcatgtt gagtgagcaa gtgaagacca atattcaaca    540

ggcagttgca gctgctccct ggtggttacc tgtgaaaggc gctaactgga gacacccaga    600

agggcctgac tctactattc tgcacaggcc ggatcatcca gttctccatg tgtcctggaa    660

tgatgcggtt gcctactgca cttgggcagg gaagcggctg cccacggaag ctgagtggga    720

atacagctgt cgaggaggcc tgcataatag acttttcccc tggggcaaca aactgcagcc    780

caaaggccag cattatgcca acatttggca gggcgagttt ccggtgacca acactggtga    840

ggatggcttc caaggaactg cgcctgttga tgccttccct cccaatggtt atggcttata    900

caacatagtg gggaacgcat gggaatggac ttcagactgg tggactgttc atcattctgt    960

tgaagaaacg cttaacccaa aaggtccccc ttctgggaaa gaccgagtga agaaaggtgg   1020

atcctacatg tgccataggt cccaagagta ctatgatccc tattttcaag atgtggcatc   1080

tgagatgttg agaagacaca cagccagcag gtggaaggcc ttctcatctc tagaaccatg   1140

ctgctcaata cgtaggcatc agcaatatgc agctattgaa cgtttgacat gtggcaagtt   1200

tgaattgaga tgtgctagtt taagaaaaat agattgcctc aacaccaaca ttgcctgtag   1260

ctactccatg aggcaagatg gacccagact ccactgtgtg gactgacctc ccagaaggat   1320

cctcctgtcc ctgaaggcca ctctgccttc agctacaggc cccagtgctg attgtgatac   1380

ttaacaaggg ctttcagatg tctgaaacaa gagtatagca taaagttaag aatgcggctt   1440

ctggagagac agacttggtt tcaaattcag ctctgtgacc ttgggtgcac agcaaagtct   1500

tcttctcccc ccgatgaaag aatgggaagg actcaggaag gctcaacttg caaactcccc   1560

agtatcaagt ggctgccttc aaaatccaac ccttctcttc ccagctcatt tccagtatgt   1620

attttcaaag gccatgtcat ttttgaagtg cctgagaaga aaacagaact gccagcagac   1680

tatgggacaa acgactaaat gccctccaga cgttccagag tcctctgcct ctcaggcttc   1740

agttcttcct gaaggaatct ggagctggaa agcaggaagc aatttgctgt ggaatttttt   1800

ccatcacaga ctccaagttc ctcagccttt ggactcttga acttacacca gtgttttggc   1860

aggagcgctc gggcctttgg ccacagactg aaggctgcat tgtcagcttc cctacttttg   1920

aggttttggg actcagactg atccaccact ggcttccttg ctcttcaact tgaagacggc   1980

ctatcgtgag actttacctc gtgattatgt gagtcaattc tcctaataaa ctccccttcg   2040

tatgtacata taccctatta cttctgtccc tttagagaac cctgactaat acagtagaga   2100

ttgcctggac ttattaataa taatgactct gtttagttaa tgtaacagac agataaagac   2160

aaatgagtga cacccatgca attaaaataa ttttggtggg gagtgagagg agttggttct   2220

ccactcacag tggaaagttt tagcgtatac tgctgcacat gacatgggag tattttgcac   2280

ttccactgga aaaaagtaag gggaataaaa acccctggat tctacttgct gacttgagag   2340

tgactaaagc gatttatctg aaggttcccc agggtggatt catagtggac tcaggccaga   2400

ttctctgctg atgctttgaa cttatgtcca gagcatcatc tccaccacaa aagagcttgc   2460

ctgctctgtg tcctggccaa agagatgcac gtgctctctc actgggttgt ggctcttgag   2520

taactcctgg aattacccag ctggaatttc tattcctttg gaccacaaat ttcatatctt   2580

cacctgctgc ctatatcatg ctaaaagatg gaaatgtctc aactaaacca tgtaggtgga   2640

ctagcctcat taacaagata agcaatgggc cattttctca ctggttatta actatgtaca   2700

ttatctatga aataacatat ctggtcatgg ttactactct attctgtagg gtggaataga   2760

aaaaggtaga ggatatatat ttcagttgca tttttaaaat tgtttatttt gttttttaat   2820

tgacaaataa tattaggttg gtgcaaaagt aattgcagtt tttgccatta aaggtagaca   2880

aggctgggca cggtggctca gcacgcttgt aatcccagca ctttgggagg cagaggcggg   2940

cagatcacaa ggtcaggaga ccgagaccat cctggctaac acggtgaaac cccatctcta   3000

ctaaaaatac aaaaaattag ccgggtgtgg tggtgggcac ctgtagtccc agctactcgg   3060

gaggctgagg caggagaatg gcgtgaacct gggaggtgga gcttgtagtg agctgcacca   3120

ctgcactcca gcctgggcaa cagagcaaga ccccatatc                          3159


<210>  9002
<211>  426
<212>  PRT
<213>  Homosapiens

<400>  9002

Met Ala Ala Pro Ala Leu Gly Leu Val Cys Gly Arg Cys Pro Glu Leu 
1               5                   10                  15      


Gly Leu Val Leu Leu Leu Leu Leu Leu Ser Leu Leu Cys Gly Ala Ala 
            20                  25                  30          


Gly Ser Gln Glu Ala Gly Thr Gly Ala Gly Ala Gly Ser Leu Ala Gly 
        35                  40                  45              


Ser Cys Gly Cys Gly Thr Pro Gln Arg Pro Gly Ala His Gly Ser Ser 
    50                  55                  60                  


Ala Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Ala Pro Gly Pro Val 
65                  70                  75                  80  


Pro Gly Glu Arg Gln Leu Ala His Ser Lys Met Val Pro Ile Pro Ala 
                85                  90                  95      


Gly Val Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys Gln Asp Gly 
            100                 105                 110         


Glu Ala Pro Ala Arg Arg Val Thr Ile Asp Ala Phe Tyr Met Asp Ala 
        115                 120                 125             


Tyr Glu Val Ser Asn Thr Glu Phe Glu Lys Phe Val Asn Ser Thr Gly 
    130                 135                 140                 


Tyr Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Glu Gly 
145                 150                 155                 160 


Met Leu Ser Glu Gln Val Lys Thr Asn Ile Gln Gln Ala Val Ala Ala 
                165                 170                 175     


Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro Glu 
            180                 185                 190         


Gly Pro Asp Ser Thr Ile Leu His Arg Pro Asp His Pro Val Leu His 
        195                 200                 205             


Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys Arg 
    210                 215                 220                 


Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu His 
225                 230                 235                 240 


Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys Gly Gln His 
                245                 250                 255     


Tyr Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Thr Asn Thr Gly Glu 
            260                 265                 270         


Asp Gly Phe Gln Gly Thr Ala Pro Val Asp Ala Phe Pro Pro Asn Gly 
        275                 280                 285             


Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser Asp 
    290                 295                 300                 


Trp Trp Thr Val His His Ser Val Glu Glu Thr Leu Asn Pro Lys Gly 
305                 310                 315                 320 


Pro Pro Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser Tyr Met Cys 
                325                 330                 335     


His Arg Ser Gln Glu Tyr Tyr Asp Pro Tyr Phe Gln Asp Val Ala Ser 
            340                 345                 350         


Glu Met Leu Arg Arg His Thr Ala Ser Arg Trp Lys Ala Phe Ser Ser 
        355                 360                 365             


Leu Glu Pro Cys Cys Ser Ile Arg Arg His Gln Gln Tyr Ala Ala Ile 
    370                 375                 380                 


Glu Arg Leu Thr Cys Gly Lys Phe Glu Leu Arg Cys Ala Ser Leu Arg 
385                 390                 395                 400 


Lys Ile Asp Cys Leu Asn Thr Asn Ile Ala Cys Ser Tyr Ser Met Arg 
                405                 410                 415     


Gln Asp Gly Pro Arg Leu His Cys Val Asp 
            420                 425     


<210>  9003
<211>  2128
<212>  DNA
<213>  Homosapiens

<400>  9003
atccaccgcg cggcccagga ctgtcagggt agtgggcgtt gcgtgaggcg ggtaaatgtt     60

cgcggaagcg gcaaagacga cacggccttg tgggatggcg gagtttaagg agaagcctga    120

ggccccgact gagcagctgg atgtcgcgtg cggccaggaa aacttgccgg tgggcgcgtg    180

gcccccgggg gccgcgccgg cgcccttcca gtacactcct gatcatgtag ttggacctgg    240

agcagacatt gatcccactc aaataacctt tcccggatgc atttgtgtca aaactccctg    300

cctccctggc acttgctcct gtctccgcca tggagagaac tatgatgata actcatgcct    360

tagagatata ggatctggag gaaagtatgc agagcctgtt tttgaatgca atgtcctgtg    420

ccgatgcagt gaccactgca gaaacagagt ggtccagaaa ggtctacagt tccacttcca    480

agtgttcaag acgcataaaa aaggctgggg acttcgtacc ttggaattta taccgaaagg    540

aaggtttgtc tgtgaatatg ctggtgaggt tttaggattc tctgaagttc agagaagaat    600

tcacttacaa acaaaatccg actccaatta cattatagcc atcagggaac atgtttataa    660

tgggcaggta atggaaacat ttgttgaccc tacttatata ggaaatattg gaagattcct    720

taatcattct tgtgagccaa accttttgat gattcctgtc cgaattgact caatggtacc    780

taagttggca ctttttgcag ccaaagatat tgtgccagaa gaagaactct cttatgatta    840

ttcaggaaga tatcttaatc taacagtcag tgaagacaaa gaaaggctag atcatgggaa    900

actaaggaaa ccttgttact gtggtgccaa atcatgtact gctttcctgc cttttgacag    960

ttctctgtac tgccccgtag aaaagtcgaa catcagttgt ggaaatgaga aggaacccag   1020

catgtgtggc tcagcccctt ctgtgttccc ctcctgcaag cgattgaccc ttgagactat   1080

gaaaatgatg ttagacaaaa agcaaattcg agcaattttc ttattcgagt tcaaaatggg   1140

tcgtaaagca gcagaaacaa ctcgcaacat caacaatgca tttggcccag gaactgctaa   1200

cgaacgtaca gtgcagtggt ggttcaagaa gttttgcaaa ggagatgaga gccttgaaga   1260

tgaggagcgt agtggccggc catcagaagt tgacaacgac cagttgagag caatcatcga   1320

agctgatccc cttacaacta cacgagaagt tgctgaagaa ctcaatgtca accattctac   1380

ggtcgttcga catttgaagc aaattggaaa ggtgaaaaag ctcgataagt gggtgcctca   1440

tgagctgact gaaaatcaaa aaaatcgtcg ttttgaagtg tcatcttctc ttattctacg   1500

caaccacaac gaaccatttc tcgatcggat tgtgacgtgt gatgaaaagt ggattttata   1560

tgacaaccgg cgacgatcag ctcagtggtt ggatcaagaa gaagctccaa agcacttccc   1620

aaagccaatc ttgcacccaa aaaaggtcat ggtcactatt tggtggtctg ctgctggtct   1680

gatccactac agctttctga atcccggtga aaccattaca tctgagaagt atgctcagga   1740

aatcgatgag atgaaccaaa aactgcaacg cctgcagctg gcattggtca acagaaaggg   1800

cccaattctt ctccacgaca atgcccgacc gcatgttgca caacccacac ttcaaaagtt   1860

gaatgaattg ggctatgaag ttttgcctca tccaccgtat tcacctgacc tcttgccaac   1920

caactaccac gtctttaagc atctcaacaa ctttttgcag ggaaaacgct tccacaacca   1980

gcaggatgca gaaaatgctt tccaagagtt cgtcgaatcc caaagcacgg atttttacgc   2040

tacaggaata aaccaactta tttctcgttg gcaaaaatgt gttgattgta atggttccta   2100

ttttgattaa taaaaatgcg ttgagcct                                      2128


<210>  9004
<211>  684
<212>  PRT
<213>  Homosapiens

<400>  9004

Met Phe Ala Glu Ala Ala Lys Thr Thr Arg Pro Cys Gly Met Ala Glu 
1               5                   10                  15      


Phe Lys Glu Lys Pro Glu Ala Pro Thr Glu Gln Leu Asp Val Ala Cys 
            20                  25                  30          


Gly Gln Glu Asn Leu Pro Val Gly Ala Trp Pro Pro Gly Ala Ala Pro 
        35                  40                  45              


Ala Pro Phe Gln Tyr Thr Pro Asp His Val Val Gly Pro Gly Ala Asp 
    50                  55                  60                  


Ile Asp Pro Thr Gln Ile Thr Phe Pro Gly Cys Ile Cys Val Lys Thr 
65                  70                  75                  80  


Pro Cys Leu Pro Gly Thr Cys Ser Cys Leu Arg His Gly Glu Asn Tyr 
                85                  90                  95      


Asp Asp Asn Ser Cys Leu Arg Asp Ile Gly Ser Gly Gly Lys Tyr Ala 
            100                 105                 110         


Glu Pro Val Phe Glu Cys Asn Val Leu Cys Arg Cys Ser Asp His Cys 
        115                 120                 125             


Arg Asn Arg Val Val Gln Lys Gly Leu Gln Phe His Phe Gln Val Phe 
    130                 135                 140                 


Lys Thr His Lys Lys Gly Trp Gly Leu Arg Thr Leu Glu Phe Ile Pro 
145                 150                 155                 160 


Lys Gly Arg Phe Val Cys Glu Tyr Ala Gly Glu Val Leu Gly Phe Ser 
                165                 170                 175     


Glu Val Gln Arg Arg Ile His Leu Gln Thr Lys Ser Asp Ser Asn Tyr 
            180                 185                 190         


Ile Ile Ala Ile Arg Glu His Val Tyr Asn Gly Gln Val Met Glu Thr 
        195                 200                 205             


Phe Val Asp Pro Thr Tyr Ile Gly Asn Ile Gly Arg Phe Leu Asn His 
    210                 215                 220                 


Ser Cys Glu Pro Asn Leu Leu Met Ile Pro Val Arg Ile Asp Ser Met 
225                 230                 235                 240 


Val Pro Lys Leu Ala Leu Phe Ala Ala Lys Asp Ile Val Pro Glu Glu 
                245                 250                 255     


Glu Leu Ser Tyr Asp Tyr Ser Gly Arg Tyr Leu Asn Leu Thr Val Ser 
            260                 265                 270         


Glu Asp Lys Glu Arg Leu Asp His Gly Lys Leu Arg Lys Pro Cys Tyr 
        275                 280                 285             


Cys Gly Ala Lys Ser Cys Thr Ala Phe Leu Pro Phe Asp Ser Ser Leu 
    290                 295                 300                 


Tyr Cys Pro Val Glu Lys Ser Asn Ile Ser Cys Gly Asn Glu Lys Glu 
305                 310                 315                 320 


Pro Ser Met Cys Gly Ser Ala Pro Ser Val Phe Pro Ser Cys Lys Arg 
                325                 330                 335     


Leu Thr Leu Glu Thr Met Lys Met Met Leu Asp Lys Lys Gln Ile Arg 
            340                 345                 350         


Ala Ile Phe Leu Phe Glu Phe Lys Met Gly Arg Lys Ala Ala Glu Thr 
        355                 360                 365             


Thr Arg Asn Ile Asn Asn Ala Phe Gly Pro Gly Thr Ala Asn Glu Arg 
    370                 375                 380                 


Thr Val Gln Trp Trp Phe Lys Lys Phe Cys Lys Gly Asp Glu Ser Leu 
385                 390                 395                 400 


Glu Asp Glu Glu Arg Ser Gly Arg Pro Ser Glu Val Asp Asn Asp Gln 
                405                 410                 415     


Leu Arg Ala Ile Ile Glu Ala Asp Pro Leu Thr Thr Thr Arg Glu Val 
            420                 425                 430         


Ala Glu Glu Leu Asn Val Asn His Ser Thr Val Val Arg His Leu Lys 
        435                 440                 445             


Gln Ile Gly Lys Val Lys Lys Leu Asp Lys Trp Val Pro His Glu Leu 
    450                 455                 460                 


Thr Glu Asn Gln Lys Asn Arg Arg Phe Glu Val Ser Ser Ser Leu Ile 
465                 470                 475                 480 


Leu Arg Asn His Asn Glu Pro Phe Leu Asp Arg Ile Val Thr Cys Asp 
                485                 490                 495     


Glu Lys Trp Ile Leu Tyr Asp Asn Arg Arg Arg Ser Ala Gln Trp Leu 
            500                 505                 510         


Asp Gln Glu Glu Ala Pro Lys His Phe Pro Lys Pro Ile Leu His Pro 
        515                 520                 525             


Lys Lys Val Met Val Thr Ile Trp Trp Ser Ala Ala Gly Leu Ile His 
    530                 535                 540                 


Tyr Ser Phe Leu Asn Pro Gly Glu Thr Ile Thr Ser Glu Lys Tyr Ala 
545                 550                 555                 560 


Gln Glu Ile Asp Glu Met Asn Gln Lys Leu Gln Arg Leu Gln Leu Ala 
                565                 570                 575     


Leu Val Asn Arg Lys Gly Pro Ile Leu Leu His Asp Asn Ala Arg Pro 
            580                 585                 590         


His Val Ala Gln Pro Thr Leu Gln Lys Leu Asn Glu Leu Gly Tyr Glu 
        595                 600                 605             


Val Leu Pro His Pro Pro Tyr Ser Pro Asp Leu Leu Pro Thr Asn Tyr 
    610                 615                 620                 


His Val Phe Lys His Leu Asn Asn Phe Leu Gln Gly Lys Arg Phe His 
625                 630                 635                 640 


Asn Gln Gln Asp Ala Glu Asn Ala Phe Gln Glu Phe Val Glu Ser Gln 
                645                 650                 655     


Ser Thr Asp Phe Tyr Ala Thr Gly Ile Asn Gln Leu Ile Ser Arg Trp 
            660                 665                 670         


Gln Lys Cys Val Asp Cys Asn Gly Ser Tyr Phe Asp 
        675                 680                 


<210>  9005
<211>  3057
<212>  DNA
<213>  Homosapiens

<400>  9005
atccaccgcg cggcccagga ctgtcagggt agtgggcgtt gcgtgaggcg ggtaaatgtt     60

cgcggaagcg gcaaagacga cacggccttg tgggatggcg gagtttaagg agaagcctga    120

ggccccgact gagcagctgg atgtcgcgtg cggccaggaa aacttgccgg tgggcgcgtg    180

gcccccgggg gccgcgccgg cgcccttcca gtacactcct gatcatgtag ttggacctgg    240

agcagacatt gatcccactc aaataacctt tcccggatgc atttgtgtca aaactccctg    300

cctccctggc acttgctcct gtctccgcca tggagagaac tatgatgata actcatgcct    360

tagagatata ggatctggag gaaagtatgc agagcctgtt tttgaatgca atgtcctgtg    420

ccgatgcagt gaccactgca gaaacagagt ggtccagaaa ggtctacagt tccacttcca    480

agtgttcaag acgcataaaa aaggctgggg acttcgtacc ttggaattta taccgaaagg    540

aaggtttgtc tgtgaatatg ctggtgaggt tttaggattc tctgaagttc agagaagaat    600

tcacttacaa acaaaatccg actccaatta cattatagcc atcagggaac atgtttataa    660

tgggcaggta atggaaacat ttgttgaccc tacttatata ggaaatattg gaagattcct    720

taatcattct tgtgagccaa accttttgat gattcctgtc cgaattgact caatggtacc    780

taagttggca ctttttgcag ccaaagatat tgtgccagaa gaagaactct cttatgatta    840

ttcaggaaga tatcttaatc taacagtcag tgaagacaaa gaaaggctag atcatgggaa    900

actaaggaaa ccttgttact gtggtgccaa atcatgtact gctttcctgc cttttgacag    960

ttctctgtac tgccccgtag aaaagtcgaa catcagttgt ggaaatgaga aggaacccag   1020

catgtgtggc tcagcccctt ctgtgttccc ctcctgcaag cgattgaccc ttgagactat   1080

gaaaatgatg ttagacaaaa agcaaattcg agcaattttc ttattcgagt tcaaaatggg   1140

tcgtaaagca gcagaaacaa ctcgcaacat caacaatgca tttggcccag gaactgctaa   1200

cgaacgtaca gtgcagtggt ggttcaagaa gttttgcaaa ggagatgaga gccttgaaga   1260

tgaggagcgt agtggccggc catcagaagt tgacaacgac cagttgagag caatcatcga   1320

agctgatccc cttacaacta cacgagaagt tgctgaagaa ctcaatgtca accattctac   1380

ggtcgttcga catttgaagc aaattggaaa ggtgaaaaag ctcgataagt gggtgcctca   1440

tgagctgact gaaaatcaaa aaaatcgtcg ttttgaagtg tcatcttctc ttattctacg   1500

caaccacaac gaaccatttc tcgatcggat tgtgacgtgt gatgaaaagt ggattttata   1560

tgacaaccgg cgacgatcag ctcagtggtt ggatcaagaa gaagctccaa agcacttccc   1620

aaagccaatc ttgcacccaa aaaaggtcat ggtcactatt tggtggtctg ctgctggtct   1680

gatccactac agctttctga atcccggtga aaccattaca tctgagaagt atgctcagga   1740

aatcgatgag atgaaccaaa aactgcaacg cctgcagctg gcattggtca acagaaaggg   1800

cccaattctt ctccacgaca atgcccgacc gcatgttgca caacccacac ttcaaaagtt   1860

gaatgaattg ggctatgaag ttttgcctca tccaccgtat tcacctgacc tcttgccaac   1920

caactaccac gtctttaagc atctcaacaa ctttttgcag ggaaaacgct tccacaacca   1980

gcaggatgca gaaaatgctt tccaagagtt cgtcgaatcc caaagcacgg atttttacgc   2040

tacaggaata aaccaactta tttctcgttg gcaaaaatgt gttgattgta atggttccta   2100

ttttgattaa taaaaatgcg ttgagcctag ttataatgat ttaaaattca cagtccaaaa   2160

ccgcagttag ttttgcacca acccaatatc ttcatagatt gaaatataaa ttaaaattgc   2220

atttgaagta gattccacgg actttattaa gaatgtagaa atgtggcctg gcatggtggc   2280

ttacaactgt aatcccagca ctttgggagg cccaggcggg cagatcactt gagtccaatt   2340

gttcaggacc agcctgggca acatagtgag accctgactc taataaaata attttttaaa   2400

aaaagattaa aacatgtacc ttgaaaagca ttttggccca agaataataa cgatcacact   2460

tgaagaacaa agcttttctt taaaaaaatt ttcctttaat tttcaaatta ctattcacaa   2520

aatagcagtg gctgttagat tttgttcttg gccaaatgga aaattttgcc ctaattaaaa   2580

tgtagtcact ctccagtgtg ttaccattga acaaatcact gaacctttcc aagtcaaagt   2640

ttccttagtt gggaagattg agttaacaca tgcaaagggg ttagagcaat gcctgagtat   2700

atagaaagta ttcaataaat gtaaattatt agtcttgaga actgtctgta ggatgtgacc   2760

caaagttctc ccttctattc aggtgtaatt aggatataat gtccttcaaa tggcagactt   2820

aaagggggaa aaagtcacta agaggtgacc agaagggtta gagctgagca agagaggttc   2880

ctgccctgag ccctgcattt tagagtgcct aaggttacat acatacacac acacacgagt   2940

taaagaagac atggatacca taaccagaca catgagttaa agaagacatg gataccataa   3000

ccaaagacat tactaggaaa gaaaactaat accaatatcc cttttgaata cagaggc      3057


<210>  9006
<211>  684
<212>  PRT
<213>  Homosapiens

<400>  9006

Met Phe Ala Glu Ala Ala Lys Thr Thr Arg Pro Cys Gly Met Ala Glu 
1               5                   10                  15      


Phe Lys Glu Lys Pro Glu Ala Pro Thr Glu Gln Leu Asp Val Ala Cys 
            20                  25                  30          


Gly Gln Glu Asn Leu Pro Val Gly Ala Trp Pro Pro Gly Ala Ala Pro 
        35                  40                  45              


Ala Pro Phe Gln Tyr Thr Pro Asp His Val Val Gly Pro Gly Ala Asp 
    50                  55                  60                  


Ile Asp Pro Thr Gln Ile Thr Phe Pro Gly Cys Ile Cys Val Lys Thr 
65                  70                  75                  80  


Pro Cys Leu Pro Gly Thr Cys Ser Cys Leu Arg His Gly Glu Asn Tyr 
                85                  90                  95      


Asp Asp Asn Ser Cys Leu Arg Asp Ile Gly Ser Gly Gly Lys Tyr Ala 
            100                 105                 110         


Glu Pro Val Phe Glu Cys Asn Val Leu Cys Arg Cys Ser Asp His Cys 
        115                 120                 125             


Arg Asn Arg Val Val Gln Lys Gly Leu Gln Phe His Phe Gln Val Phe 
    130                 135                 140                 


Lys Thr His Lys Lys Gly Trp Gly Leu Arg Thr Leu Glu Phe Ile Pro 
145                 150                 155                 160 


Lys Gly Arg Phe Val Cys Glu Tyr Ala Gly Glu Val Leu Gly Phe Ser 
                165                 170                 175     


Glu Val Gln Arg Arg Ile His Leu Gln Thr Lys Ser Asp Ser Asn Tyr 
            180                 185                 190         


Ile Ile Ala Ile Arg Glu His Val Tyr Asn Gly Gln Val Met Glu Thr 
        195                 200                 205             


Phe Val Asp Pro Thr Tyr Ile Gly Asn Ile Gly Arg Phe Leu Asn His 
    210                 215                 220                 


Ser Cys Glu Pro Asn Leu Leu Met Ile Pro Val Arg Ile Asp Ser Met 
225                 230                 235                 240 


Val Pro Lys Leu Ala Leu Phe Ala Ala Lys Asp Ile Val Pro Glu Glu 
                245                 250                 255     


Glu Leu Ser Tyr Asp Tyr Ser Gly Arg Tyr Leu Asn Leu Thr Val Ser 
            260                 265                 270         


Glu Asp Lys Glu Arg Leu Asp His Gly Lys Leu Arg Lys Pro Cys Tyr 
        275                 280                 285             


Cys Gly Ala Lys Ser Cys Thr Ala Phe Leu Pro Phe Asp Ser Ser Leu 
    290                 295                 300                 


Tyr Cys Pro Val Glu Lys Ser Asn Ile Ser Cys Gly Asn Glu Lys Glu 
305                 310                 315                 320 


Pro Ser Met Cys Gly Ser Ala Pro Ser Val Phe Pro Ser Cys Lys Arg 
                325                 330                 335     


Leu Thr Leu Glu Thr Met Lys Met Met Leu Asp Lys Lys Gln Ile Arg 
            340                 345                 350         


Ala Ile Phe Leu Phe Glu Phe Lys Met Gly Arg Lys Ala Ala Glu Thr 
        355                 360                 365             


Thr Arg Asn Ile Asn Asn Ala Phe Gly Pro Gly Thr Ala Asn Glu Arg 
    370                 375                 380                 


Thr Val Gln Trp Trp Phe Lys Lys Phe Cys Lys Gly Asp Glu Ser Leu 
385                 390                 395                 400 


Glu Asp Glu Glu Arg Ser Gly Arg Pro Ser Glu Val Asp Asn Asp Gln 
                405                 410                 415     


Leu Arg Ala Ile Ile Glu Ala Asp Pro Leu Thr Thr Thr Arg Glu Val 
            420                 425                 430         


Ala Glu Glu Leu Asn Val Asn His Ser Thr Val Val Arg His Leu Lys 
        435                 440                 445             


Gln Ile Gly Lys Val Lys Lys Leu Asp Lys Trp Val Pro His Glu Leu 
    450                 455                 460                 


Thr Glu Asn Gln Lys Asn Arg Arg Phe Glu Val Ser Ser Ser Leu Ile 
465                 470                 475                 480 


Leu Arg Asn His Asn Glu Pro Phe Leu Asp Arg Ile Val Thr Cys Asp 
                485                 490                 495     


Glu Lys Trp Ile Leu Tyr Asp Asn Arg Arg Arg Ser Ala Gln Trp Leu 
            500                 505                 510         


Asp Gln Glu Glu Ala Pro Lys His Phe Pro Lys Pro Ile Leu His Pro 
        515                 520                 525             


Lys Lys Val Met Val Thr Ile Trp Trp Ser Ala Ala Gly Leu Ile His 
    530                 535                 540                 


Tyr Ser Phe Leu Asn Pro Gly Glu Thr Ile Thr Ser Glu Lys Tyr Ala 
545                 550                 555                 560 


Gln Glu Ile Asp Glu Met Asn Gln Lys Leu Gln Arg Leu Gln Leu Ala 
                565                 570                 575     


Leu Val Asn Arg Lys Gly Pro Ile Leu Leu His Asp Asn Ala Arg Pro 
            580                 585                 590         


His Val Ala Gln Pro Thr Leu Gln Lys Leu Asn Glu Leu Gly Tyr Glu 
        595                 600                 605             


Val Leu Pro His Pro Pro Tyr Ser Pro Asp Leu Leu Pro Thr Asn Tyr 
    610                 615                 620                 


His Val Phe Lys His Leu Asn Asn Phe Leu Gln Gly Lys Arg Phe His 
625                 630                 635                 640 


Asn Gln Gln Asp Ala Glu Asn Ala Phe Gln Glu Phe Val Glu Ser Gln 
                645                 650                 655     


Ser Thr Asp Phe Tyr Ala Thr Gly Ile Asn Gln Leu Ile Ser Arg Trp 
            660                 665                 670         


Gln Lys Cys Val Asp Cys Asn Gly Ser Tyr Phe Asp 
        675                 680                 


<210>  9007
<211>  1662
<212>  DNA
<213>  Homosapiens

<400>  9007
aaatgttcgc ggaagcggca aagacgacac ggccttgtgg gatggcggag tttaaggaga     60

agcctgaggc cccgactgag cagctggatg tcgcgtgcgg ccaggaaaac ttgccggtgg    120

gcgcgtggcc cccgggggcc gcgccggcgc ccttccagta cactcctgat catgtagttg    180

gacctggagc agacattgat cccactcaaa taacctttcc cggatgcatt tgtgtcaaaa    240

ctccctgcct ccctggcact tgctcctgtc tccgccatgg agagaactat gatgataact    300

catgccttag agatatagga tctggaggaa agtatgcaga gcctgttttt gaatgcaatg    360

tcctgtgccg atgcagtgac cactgcagaa acagagtggt ccagaaaggt ctacagttcc    420

acttccaagt gttcaagacg cataaaaaag gctggggact tcgtaccttg gaatttatac    480

cgaaaggaag gtttgtctgt gaatatgctg gtgaggtttt aggattctct gaagttcaga    540

gaagaattca cttacaaaca aaatccgact ccaattacat tatagccatc agggaacatg    600

tttataatgg gcaggtaatg gaaacatttg ttgaccctac ttatatagga aatattggaa    660

gattccttaa tcattcttgt gagccaaacc ttttgatgat tcctgtccga attgactcaa    720

tggtacctaa gttggcactt tttgcagcca aagatattgt gccagaagaa gaactctctt    780

atgattattc aggaagatat cttaatctaa cagtcagtga agacaaagaa aggctagatc    840

atgggaaact aaggaaacct tgttactgtg gtgccaaatc atgtactgct ttcctgcctt    900

ttgacagttc tctgtactgc cccgtagaaa agtcgaacat cagttgtgga aatgagaagg    960

aacccagcat gtgtggctca gccccttctg tgttcccctc ctgcaagcga ttgacccttg   1020

aggtgagtct gttcagtgat aagcagcttg cccctcccta tagtggaaga cagtggttgg   1080

ctagctttac ctctgcctag ttacataagt ttaactcagg aatgtggcag agactgcaag   1140

ttgtccatca gtatcctttc ccctttctgt aatagaattc tccatttaac aaaagtacat   1200

gactacccag aatactcact ttcctagtta gatttgtctt agtgactgtt ctagttaata   1260

ggatataagc aaaaatgaca agtccttaaa tggagatatc ctgcccttca cctcctcttt   1320

cttcctgctg gctggaatgt atacatgatg actggaactg gagcagtcat cctagacccc   1380

aggatgaccc tgggaaagga agccattgca tagaaaaatc aacaaggtta aaaggagtct   1440

aggtgtctgg tactgtagaa catcctgtca gtcgtgatct gacacctttg tactttcagg   1500

tgagaaatag tctctccctt gcttaagtca ctgttattgt aagttttcta gcactaacat   1560

cgaacctaat aatgatccaa gaaacccttg tggctgcata cctaaaccct gcttgccaac   1620

caattttaac agtaataaag ctgacttttt gatttctgtc tg                      1662


<210>  9008
<211>  365
<212>  PRT
<213>  Homosapiens

<400>  9008

Met Phe Ala Glu Ala Ala Lys Thr Thr Arg Pro Cys Gly Met Ala Glu 
1               5                   10                  15      


Phe Lys Glu Lys Pro Glu Ala Pro Thr Glu Gln Leu Asp Val Ala Cys 
            20                  25                  30          


Gly Gln Glu Asn Leu Pro Val Gly Ala Trp Pro Pro Gly Ala Ala Pro 
        35                  40                  45              


Ala Pro Phe Gln Tyr Thr Pro Asp His Val Val Gly Pro Gly Ala Asp 
    50                  55                  60                  


Ile Asp Pro Thr Gln Ile Thr Phe Pro Gly Cys Ile Cys Val Lys Thr 
65                  70                  75                  80  


Pro Cys Leu Pro Gly Thr Cys Ser Cys Leu Arg His Gly Glu Asn Tyr 
                85                  90                  95      


Asp Asp Asn Ser Cys Leu Arg Asp Ile Gly Ser Gly Gly Lys Tyr Ala 
            100                 105                 110         


Glu Pro Val Phe Glu Cys Asn Val Leu Cys Arg Cys Ser Asp His Cys 
        115                 120                 125             


Arg Asn Arg Val Val Gln Lys Gly Leu Gln Phe His Phe Gln Val Phe 
    130                 135                 140                 


Lys Thr His Lys Lys Gly Trp Gly Leu Arg Thr Leu Glu Phe Ile Pro 
145                 150                 155                 160 


Lys Gly Arg Phe Val Cys Glu Tyr Ala Gly Glu Val Leu Gly Phe Ser 
                165                 170                 175     


Glu Val Gln Arg Arg Ile His Leu Gln Thr Lys Ser Asp Ser Asn Tyr 
            180                 185                 190         


Ile Ile Ala Ile Arg Glu His Val Tyr Asn Gly Gln Val Met Glu Thr 
        195                 200                 205             


Phe Val Asp Pro Thr Tyr Ile Gly Asn Ile Gly Arg Phe Leu Asn His 
    210                 215                 220                 


Ser Cys Glu Pro Asn Leu Leu Met Ile Pro Val Arg Ile Asp Ser Met 
225                 230                 235                 240 


Val Pro Lys Leu Ala Leu Phe Ala Ala Lys Asp Ile Val Pro Glu Glu 
                245                 250                 255     


Glu Leu Ser Tyr Asp Tyr Ser Gly Arg Tyr Leu Asn Leu Thr Val Ser 
            260                 265                 270         


Glu Asp Lys Glu Arg Leu Asp His Gly Lys Leu Arg Lys Pro Cys Tyr 
        275                 280                 285             


Cys Gly Ala Lys Ser Cys Thr Ala Phe Leu Pro Phe Asp Ser Ser Leu 
    290                 295                 300                 


Tyr Cys Pro Val Glu Lys Ser Asn Ile Ser Cys Gly Asn Glu Lys Glu 
305                 310                 315                 320 


Pro Ser Met Cys Gly Ser Ala Pro Ser Val Phe Pro Ser Cys Lys Arg 
                325                 330                 335     


Leu Thr Leu Glu Val Ser Leu Phe Ser Asp Lys Gln Leu Ala Pro Pro 
            340                 345                 350         


Tyr Ser Gly Arg Gln Trp Leu Ala Ser Phe Thr Ser Ala 
        355                 360                 365 


<210>  9009
<211>  802
<212>  DNA
<213>  Homosapiens

<400>  9009
aaatgttcgc ggaagcggca aagacgacac ggccttgtgg gatggcggag tttaaggaga     60

agcctgaggc cccgactgag cagctggatg tcgcgtgcgg ccaggaaaac ttgccggtgg    120

gcgcgtggcc cccgggggcc gcgccggcgc ccttccagac tatgaaaatg atgttagaca    180

aaaagcaaat tcgagcaatt ttcttattcg agttcaaaat gggtcgtaaa gcagcagaaa    240

caactcgcaa catcaacaat gcatttggcc caggaactgc taacgaacgt acagtgcagt    300

ggtggttcaa gaagttttgc aaaggagatg agagccttga agatgaggag cgtagtggcc    360

ggccatcaga agttgacaac gaccagttga gagcaatcat cgaagctgat ccccttacaa    420

ctacacgaga agttgctgaa gaactcaatg tcaaccattc tacggtcgtt cgacatttga    480

agcaaattgg aaaggtgaaa aagctcgata agtgggtgcc tcatgagctg actgaaaatc    540

aaaaaaatcg tcgttttgaa gtgtcatctt ctcttattct acgcaaccac aacgaaccat    600

ttctcgatcg gattgtgacg tgtgatgaaa agtggatttt atatgacaac cggcgacgat    660

cagctcagtg gttggatcaa gaagaagctc caaagcactt cccaaagcca atcttgcacc    720

caaaaaaggt catggtcact atttggtggt ctgctgctgg tctgatccac tacagctttc    780

tgaatcccgg tgaaaccatt ac                                             802


<210>  9010
<211>  265
<212>  PRT
<213>  Homosapiens

<400>  9010

Met Phe Ala Glu Ala Ala Lys Thr Thr Arg Pro Cys Gly Met Ala Glu 
1               5                   10                  15      


Phe Lys Glu Lys Pro Glu Ala Pro Thr Glu Gln Leu Asp Val Ala Cys 
            20                  25                  30          


Gly Gln Glu Asn Leu Pro Val Gly Ala Trp Pro Pro Gly Ala Ala Pro 
        35                  40                  45              


Ala Pro Phe Gln Thr Met Lys Met Met Leu Asp Lys Lys Gln Ile Arg 
    50                  55                  60                  


Ala Ile Phe Leu Phe Glu Phe Lys Met Gly Arg Lys Ala Ala Glu Thr 
65                  70                  75                  80  


Thr Arg Asn Ile Asn Asn Ala Phe Gly Pro Gly Thr Ala Asn Glu Arg 
                85                  90                  95      


Thr Val Gln Trp Trp Phe Lys Lys Phe Cys Lys Gly Asp Glu Ser Leu 
            100                 105                 110         


Glu Asp Glu Glu Arg Ser Gly Arg Pro Ser Glu Val Asp Asn Asp Gln 
        115                 120                 125             


Leu Arg Ala Ile Ile Glu Ala Asp Pro Leu Thr Thr Thr Arg Glu Val 
    130                 135                 140                 


Ala Glu Glu Leu Asn Val Asn His Ser Thr Val Val Arg His Leu Lys 
145                 150                 155                 160 


Gln Ile Gly Lys Val Lys Lys Leu Asp Lys Trp Val Pro His Glu Leu 
                165                 170                 175     


Thr Glu Asn Gln Lys Asn Arg Arg Phe Glu Val Ser Ser Ser Leu Ile 
            180                 185                 190         


Leu Arg Asn His Asn Glu Pro Phe Leu Asp Arg Ile Val Thr Cys Asp 
        195                 200                 205             


Glu Lys Trp Ile Leu Tyr Asp Asn Arg Arg Arg Ser Ala Gln Trp Leu 
    210                 215                 220                 


Asp Gln Glu Glu Ala Pro Lys His Phe Pro Lys Pro Ile Leu His Pro 
225                 230                 235                 240 


Lys Lys Val Met Val Thr Ile Trp Trp Ser Ala Ala Gly Leu Ile His 
                245                 250                 255     


Tyr Ser Phe Leu Asn Pro Gly Glu Thr 
            260                 265 


<210>  9011
<211>  1326
<212>  DNA
<213>  Homosapiens

<400>  9011
aaatgttcgc ggaagcggca aagacgacac ggccttgtgg gatggcggag tttaaggaga     60

agcctgaggc cccgactgag cagctggatg tcgcgtgcgg ccaggaaaac ttgccggtgg    120

gcgcgtggcc cccgggggcc gcgccggcgc ccttccagtt ctctgtactg ccccgtagaa    180

aagtcgaaca tcagttgtgg aaatgagaag gaacccagca tgtgtggctc agccccttct    240

gtgttcccct cctgcaagcg attgaccctt gagactatga aaatgatgtt agacaaaaag    300

caaattcgag caattttctt attcgagttc aaaatgggtc gtaaagcagc agaaacaact    360

cgcaacatca acaatgcatt tggcccagga actgctaacg aacgtacagt gcagtggtgg    420

ttcaagaagt tttgcaaagg agatgagagc cttgaagatg aggagcgtag tggccggcca    480

tcagaagttg acaacgacca gttgagagca atcatcgaag ctgatcccct tacaactaca    540

cgagaagttg ctgaagaact caatgtcaac cattctacgg tcgttcgaca tttgaagcaa    600

attggaaagg tgaaaaagct cgataagtgg gtgcctcatg agctgactga aaatcaaaaa    660

aatcgtcgtt ttgaagtgtc atcttctctt attctacgca accacaacga accatttctc    720

gatcggattg tgacgtgtga tgaaaagtgg attttatatg acaaccggcg acgatcagct    780

cagtggttgg atcaagaaga agctccaaag cacttcccaa agccaatctt gcacccaaaa    840

aaggtcatgg tcactatttg gtggtctgct gctggtctga tccactacag ctttctgaat    900

cccggtgaaa ccattacatc tgagaagtat gctcaggaaa tcgatgagat gaaccaaaaa    960

ctgcaacgcc tgcagctggc attggtcaac agaaagggcc caattcttct ccacgacaat   1020

gcccgaccgc atgttgcaca acccacactt caaaagttga atgaattggg ctatgaagtt   1080

ttgcctcatc caccgtattc acctgacctc ttgccaacca actaccacgt ctttaagcat   1140

ctcaacaact ttttgcaggg aaaacgcttc cacaaccagc aggatgcaga aaatgctttc   1200

caagagttcg tcgaatccca aagcacggat ttttacgcta caggaataaa ccaacttatt   1260

tctcgttggc aaaaatgtgt tgattgtaat ggttcctatt ttgattaata aaaatgcgtt   1320

gagcct                                                              1326


<210>  9012
<211>  406
<212>  PRT
<213>  Homosapiens

<400>  9012

Met Ser Arg Ala Ala Arg Lys Thr Cys Arg Trp Ala Arg Gly Pro Arg 
1               5                   10                  15      


Gly Pro Arg Arg Arg Pro Ser Ser Ser Leu Tyr Cys Pro Val Glu Lys 
            20                  25                  30          


Ser Asn Ile Ser Cys Gly Asn Glu Lys Glu Pro Ser Met Cys Gly Ser 
        35                  40                  45              


Ala Pro Ser Val Phe Pro Ser Cys Lys Arg Leu Thr Leu Glu Thr Met 
    50                  55                  60                  


Lys Met Met Leu Asp Lys Lys Gln Ile Arg Ala Ile Phe Leu Phe Glu 
65                  70                  75                  80  


Phe Lys Met Gly Arg Lys Ala Ala Glu Thr Thr Arg Asn Ile Asn Asn 
                85                  90                  95      


Ala Phe Gly Pro Gly Thr Ala Asn Glu Arg Thr Val Gln Trp Trp Phe 
            100                 105                 110         


Lys Lys Phe Cys Lys Gly Asp Glu Ser Leu Glu Asp Glu Glu Arg Ser 
        115                 120                 125             


Gly Arg Pro Ser Glu Val Asp Asn Asp Gln Leu Arg Ala Ile Ile Glu 
    130                 135                 140                 


Ala Asp Pro Leu Thr Thr Thr Arg Glu Val Ala Glu Glu Leu Asn Val 
145                 150                 155                 160 


Asn His Ser Thr Val Val Arg His Leu Lys Gln Ile Gly Lys Val Lys 
                165                 170                 175     


Lys Leu Asp Lys Trp Val Pro His Glu Leu Thr Glu Asn Gln Lys Asn 
            180                 185                 190         


Arg Arg Phe Glu Val Ser Ser Ser Leu Ile Leu Arg Asn His Asn Glu 
        195                 200                 205             


Pro Phe Leu Asp Arg Ile Val Thr Cys Asp Glu Lys Trp Ile Leu Tyr 
    210                 215                 220                 


Asp Asn Arg Arg Arg Ser Ala Gln Trp Leu Asp Gln Glu Glu Ala Pro 
225                 230                 235                 240 


Lys His Phe Pro Lys Pro Ile Leu His Pro Lys Lys Val Met Val Thr 
                245                 250                 255     


Ile Trp Trp Ser Ala Ala Gly Leu Ile His Tyr Ser Phe Leu Asn Pro 
            260                 265                 270         


Gly Glu Thr Ile Thr Ser Glu Lys Tyr Ala Gln Glu Ile Asp Glu Met 
        275                 280                 285             


Asn Gln Lys Leu Gln Arg Leu Gln Leu Ala Leu Val Asn Arg Lys Gly 
    290                 295                 300                 


Pro Ile Leu Leu His Asp Asn Ala Arg Pro His Val Ala Gln Pro Thr 
305                 310                 315                 320 


Leu Gln Lys Leu Asn Glu Leu Gly Tyr Glu Val Leu Pro His Pro Pro 
                325                 330                 335     


Tyr Ser Pro Asp Leu Leu Pro Thr Asn Tyr His Val Phe Lys His Leu 
            340                 345                 350         


Asn Asn Phe Leu Gln Gly Lys Arg Phe His Asn Gln Gln Asp Ala Glu 
        355                 360                 365             


Asn Ala Phe Gln Glu Phe Val Glu Ser Gln Ser Thr Asp Phe Tyr Ala 
    370                 375                 380                 


Thr Gly Ile Asn Gln Leu Ile Ser Arg Trp Gln Lys Cys Val Asp Cys 
385                 390                 395                 400 


Asn Gly Ser Tyr Phe Asp 
                405     


<210>  9013
<211>  785
<212>  DNA
<213>  Homosapiens

<400>  9013
aaatgttcgc ggaagcggca aagacgacac ggccttgtgg gatggcggag tttaaggaga     60

agcctgaggc cccgactgag cagctggatg tcgcgtgcgg ccaggaaaac ttgccggtgg    120

gcgcgtggcc cccgggggcc gcgccggcgc ccttccagtt ctctgtactg ccccgtagaa    180

aagtcgaaca tcagttgtgg aaatgagaag gaacccagca tgtgtggctc agccccttct    240

gtgttcccct cctgcaagcg attgaccctt gagactatga aaatgatgtt agacaaaaaa    300

aggtcatggt cactatttgg tggtctgctg ctggtctgat ccactacagc tttctgaatc    360

ccggtgaaac cattacatct gagaagtatg ctcaggaaat cgatgagatg aaccaaaaac    420

tgcaacgcct gcagctggca ttggtcaaca gaaagggccc aattcttctc cacgacaatg    480

cccgaccgca tgttgcacaa cccacacttc aaaagttgaa tgaattgggc tatgaagttt    540

tgcctcatcc accgtattca cctgacctct tgccaaccaa ctaccacgtc tttaagcatc    600

tcaacaactt tttgcaggga aaacgcttcc acaaccagca ggatgcagaa aatgctttcc    660

aagagttcgt cgaatcccaa agcacggatt tttacgctac aggaataaac caacttattt    720

ctcgttggca aaaatgtgtt gattgtaatg gttcctattt tgattaataa aaatgcgttg    780

agcct                                                                785


<210>  9014
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  9014

Met Ser Arg Ala Ala Arg Lys Thr Cys Arg Trp Ala Arg Gly Pro Arg 
1               5                   10                  15      


Gly Pro Arg Arg Arg Pro Ser Ser Ser Leu Tyr Cys Pro Val Glu Lys 
            20                  25                  30          


Ser Asn Ile Ser Cys Gly Asn Glu Lys Glu Pro Ser Met Cys Gly Ser 
        35                  40                  45              


Ala Pro Ser Val Phe Pro Ser Cys Lys Arg Leu Thr Leu Glu Thr Met 
    50                  55                  60                  


Lys Met Met Leu Asp Lys Lys Arg Ser Trp Ser Leu Phe Gly Gly Leu 
65                  70                  75                  80  


Leu Leu Val 
            


<210>  9015
<211>  701
<212>  DNA
<213>  Homosapiens

<400>  9015
ctcccagtcg cgaccttttg tcttctctta cagcgcaccc gttggtgcgc gggaataggt     60

gtgcatgccc cggcctgggc ctttttctgt tgacccacgg catcacctta gcaagggtgt    120

tgtccttttc agtccattcc ctgaagcgca gaaccggagg ccttgtgaga acctggcttt    180

ttgtccagtc ctgtcctcag aactcaagga ggcatcacgg ggggagtcat ttacctccct    240

ggtctcaggt gtctctcaca gttctctgta ctgccccgta gaaaagtcga acatcagttg    300

tggaaatgag aaggaaccca gcatgtgtgg ctcagcccct tctgtgttcc cctcctgcaa    360

gcgattgacc cttgagacta tgaaaatgat gttagacaaa aagcaaattc gagcaatttt    420

cttattcgag ttcaaaatgg gtcgtaaagc agcagaaaca actcgcaaca tcaacaatgc    480

atttggccca ggaactgcta acgaacgtac agtgcagtgg tggttcaaga agttttgcaa    540

aggagatgag agccttgaag atgaggagcg tagtggccgg ccatcagaag ttgacaacga    600

ccagttgaga gcaatcatcg aagctgatcc ccttacaact acacgagaag ttgctgaaga    660

actcaatgtc aaccattcta cggtcgttcg acatttgaag c                        701


<210>  9016
<211>  211
<212>  PRT
<213>  Homosapiens

<400>  9016

Met Pro Arg Pro Gly Pro Phe Ser Val Asp Pro Arg His His Leu Ser 
1               5                   10                  15      


Lys Gly Val Val Leu Phe Ser Pro Phe Pro Glu Ala Gln Asn Arg Arg 
            20                  25                  30          


Pro Cys Glu Asn Leu Ala Phe Cys Pro Val Leu Ser Ser Glu Leu Lys 
        35                  40                  45              


Glu Ala Ser Arg Gly Glu Ser Phe Thr Ser Leu Val Ser Gly Val Ser 
    50                  55                  60                  


His Ser Ser Leu Tyr Cys Pro Val Glu Lys Ser Asn Ile Ser Cys Gly 
65                  70                  75                  80  


Asn Glu Lys Glu Pro Ser Met Cys Gly Ser Ala Pro Ser Val Phe Pro 
                85                  90                  95      


Ser Cys Lys Arg Leu Thr Leu Glu Thr Met Lys Met Met Leu Asp Lys 
            100                 105                 110         


Lys Gln Ile Arg Ala Ile Phe Leu Phe Glu Phe Lys Met Gly Arg Lys 
        115                 120                 125             


Ala Ala Glu Thr Thr Arg Asn Ile Asn Asn Ala Phe Gly Pro Gly Thr 
    130                 135                 140                 


Ala Asn Glu Arg Thr Val Gln Trp Trp Phe Lys Lys Phe Cys Lys Gly 
145                 150                 155                 160 


Asp Glu Ser Leu Glu Asp Glu Glu Arg Ser Gly Arg Pro Ser Glu Val 
                165                 170                 175     


Asp Asn Asp Gln Leu Arg Ala Ile Ile Glu Ala Asp Pro Leu Thr Thr 
            180                 185                 190         


Thr Arg Glu Val Ala Glu Glu Leu Asn Val Asn His Ser Thr Val Val 
        195                 200                 205             


Arg His Leu 
    210     


<210>  9017
<211>  447
<212>  DNA
<213>  Homosapiens

<400>  9017
ttttgtcttc tcttacagcg cacccgttgg tgcgcgggaa taggtgtgca tgccccggcc     60

tgggcctttt tctgttgacc cacggcatca ccttagcaag ggtgttgtcc ttttcagtcc    120

attccctgaa gcgcagaacc ggaggccttg tgagaacctg gctttttgtc cagtcctgtc    180

ctcagaactc aaggaggcat cacgggggga gtcatttacc tccctggtct caggtgtctc    240

tcacagacta tgaaaatgat gttagacaaa aagcaaattc gagcaatttt cttattcgag    300

ttcaaaatgg gtcgtaaagc agcagaaaca actcgcaaca tcaacaatgc atttggccca    360

ggaactgcta acgaacgtac agtgcagtgg tggttcaaga agttttgcaa aggagatgag    420

agccttgaag atgaggagcg tagtggc                                        447


<210>  9018
<211>  67
<212>  PRT
<213>  Homosapiens

<400>  9018

Met Pro Arg Pro Gly Pro Phe Ser Val Asp Pro Arg His His Leu Ser 
1               5                   10                  15      


Lys Gly Val Val Leu Phe Ser Pro Phe Pro Glu Ala Gln Asn Arg Arg 
            20                  25                  30          


Pro Cys Glu Asn Leu Ala Phe Cys Pro Val Leu Ser Ser Glu Leu Lys 
        35                  40                  45              


Glu Ala Ser Arg Gly Glu Ser Phe Thr Ser Leu Val Ser Gly Val Ser 
    50                  55                  60                  


His Arg Leu 
65          


<210>  9019
<211>  1962
<212>  DNA
<213>  Homosapiens

<400>  9019
gtcttctctt acagcgcacc cgttggtgcg cgggaatagg tgtgcatgcc ccggcctggg     60

cctttttctg ttgacccacg gcatcacctt agcaagggtg ttgtcctttt cagtccattc    120

cctgaagcgc agaaccggag gccttgtgag aacctggctt tttgtccagt cctgtcctca    180

gaactcaagg aggcatcacg gggggagtca tttacctccc tggtctcagg tgtctctcac    240

aggtaggata agccgtgggg cctattaatg gatcgcagcc ggtgtcgtgc ataaaaacag    300

cccctcgagt cagccttagc tgtggtctcc ctcacgctgt gggctcttgg gcgagtgtaa    360

attagctgtg gctcagcctt agagtcttcc agcgtacagt ggaacagtac ctctcttccg    420

gagtgctttg aaaatggcaa ggaaaataca ctttccggtt tgcttacact cctgatcatg    480

tagttggacc tggagcagac attgatccca ctcaaataac ctttcccgga tgcatttgtg    540

tcaaaactcc ctgcctccct ggcacttgct cctgtctccg ccatggagag aactatgatg    600

ataactcatg ccttagagat ataggatctg gaggaaagta tgcagagcct gtttttgaat    660

gcaatgtcct gtgccgatgc agtgaccact gcagaaacag agtggtccag aaaggtctac    720

agttccactt ccaagtgttc aagacgcata aaaaaggctg gggacttcgt accttggaat    780

ttataccgaa aggaaggttt gtctgtgaat atgctggtga ggttttagga ttctctgaag    840

ttcagagaag aattcactta caaacaaaat ccgactccaa ttacattata gccatcaggg    900

aacatgttta taatgggcag gtaatggaaa catttgttga ccctacttat ataggaaata    960

ttggaagatt ccttaatcat tcttgtgagc caaacctttt gatgattcct gtccgaattg   1020

actcaatggt acctaagttg gcactttttg cagccaaaga tattgtgcca gaagaagaac   1080

tctcttatga ttattcagga agatatctta atctaacagt cagtgaagac aaagaaaggc   1140

tagatcatgg gaaactaagg aaaccttgtt actgtggtgc caaatcatgt actgctttcc   1200

tgccttttga cagttctctg tactgccccg tagaaaagtc gaacatcagt tgtggaaatg   1260

agaaggaacc cagcatgtgt ggctcagccc cttctgtgtt cccctcctgc aagcgattga   1320

cccttgaggt gagtctgttc agtgataagc agcttgcccc tccctatagt ggaagacagt   1380

ggttggctag ctttacctct gcctagttac ataagtttaa ctcaggaatg tggcagagac   1440

tgcaagttgt ccatcagtat cctttcccct ttctgtaata gaattctcca tttaacaaaa   1500

gtacatgact acccagaata ctcactttcc tagttagatt tgtcttagtg actgttctag   1560

ttaataggat ataagcaaaa atgacaagtc cttaaatgga gatatcctgc ccttcacctc   1620

ctctttcttc ctgctggctg gaatgtatac atgatgactg gaactggagc agtcatccta   1680

gaccccagga tgaccctggg aaaggaagcc attgcataga aaaatcaaca aggttaaaag   1740

gagtctaggt gtctggtact gtagaacatc ctgtcagtcg tgatctgaca cctttgtact   1800

ttcaggtgag aaatagtctc tcccttgctt aagtcactgt tattgtaagt tttctagcac   1860

taacatcgaa cctaataatg atccaagaaa cccttgtggc tgcataccta aaccctgctt   1920

gccaaccaat tttaacagta ataaagctga ctttttgatt tc                      1962


<210>  9020
<211>  160
<212>  PRT
<213>  Homosapiens

<400>  9020

Met Glu Thr Phe Val Asp Pro Thr Tyr Ile Gly Asn Ile Gly Arg Phe 
1               5                   10                  15      


Leu Asn His Ser Cys Glu Pro Asn Leu Leu Met Ile Pro Val Arg Ile 
            20                  25                  30          


Asp Ser Met Val Pro Lys Leu Ala Leu Phe Ala Ala Lys Asp Ile Val 
        35                  40                  45              


Pro Glu Glu Glu Leu Ser Tyr Asp Tyr Ser Gly Arg Tyr Leu Asn Leu 
    50                  55                  60                  


Thr Val Ser Glu Asp Lys Glu Arg Leu Asp His Gly Lys Leu Arg Lys 
65                  70                  75                  80  


Pro Cys Tyr Cys Gly Ala Lys Ser Cys Thr Ala Phe Leu Pro Phe Asp 
                85                  90                  95      


Ser Ser Leu Tyr Cys Pro Val Glu Lys Ser Asn Ile Ser Cys Gly Asn 
            100                 105                 110         


Glu Lys Glu Pro Ser Met Cys Gly Ser Ala Pro Ser Val Phe Pro Ser 
        115                 120                 125             


Cys Lys Arg Leu Thr Leu Glu Val Ser Leu Phe Ser Asp Lys Gln Leu 
    130                 135                 140                 


Ala Pro Pro Tyr Ser Gly Arg Gln Trp Leu Ala Ser Phe Thr Ser Ala 
145                 150                 155                 160 


<210>  9021
<211>  1740
<212>  DNA
<213>  Homosapiens

<400>  9021
gtcttctctt acagcgcacc cgttggtgcg cgggaatagg tgtgcatgcc ccggcctggg     60

cctttttctg ttgacccacg gcatcacctt agcaagggtg ttgtcctttt cagtccattc    120

cctgaagcgc agaaccggag gccttgtgag aacctggctt tttgtccagt cctgtcctca    180

gaactcaagg aggcatcacg gggggagtca tttacctccc tggtctcagg tgtctctcac    240

agtacactcc tgatcatgta gttggacctg gagcagacat tgatcccact caaataacct    300

ttcccggatg catttgtgtc aaaactccct gcctccctgg cacttgctcc tgtctccgcc    360

atggagagaa ctatgatgat aactcatgcc ttagagatat aggatctgga ggaaagtatg    420

cagagcctgt ttttgaatgc aatgtcctgt gccgatgcag tgaccactgc agaaacagag    480

tggtccagaa aggtctacag ttccacttcc aagtgttcaa gacgcataaa aaaggctggg    540

gacttcgtac cttggaattt ataccgaaag gaaggtttgt ctgtgaatat gctggtgagg    600

ttttaggatt ctctgaagtt cagagaagaa ttcacttaca aacaaaatcc gactccaatt    660

acattatagc catcagggaa catgtttata atgggcaggt aatggaaaca tttgttgacc    720

ctacttatat aggaaatatt ggaagattcc ttaatcattc ttgtgagcca aaccttttga    780

tgattcctgt ccgaattgac tcaatggtac ctaagttggc actttttgca gccaaagata    840

ttgtgccaga agaagaactc tcttatgatt attcaggaag atatcttaat ctaacagtca    900

gtgaagacaa agaaaggcta gatcatggga aactaaggaa accttgttac tgtggtgcca    960

aatcatgtac tgctttcctg ccttttgaca gttctctgta ctgccccgta gaaaagtcga   1020

acatcagttg tggaaatgag aaggaaccca gcatgtgtgg ctcagcccct tctgtgttcc   1080

cctcctgcaa gcgattgacc cttgaggtga gtctgttcag tgataagcag cttgcccctc   1140

cctatagtgg aagacagtgg ttggctagct ttacctctgc ctagttacat aagtttaact   1200

caggaatgtg gcagagactg caagttgtcc atcagtatcc tttccccttt ctgtaataga   1260

attctccatt taacaaaagt acatgactac ccagaatact cactttccta gttagatttg   1320

tcttagtgac tgttctagtt aataggatat aagcaaaaat gacaagtcct taaatggaga   1380

tatcctgccc ttcacctcct ctttcttcct gctggctgga atgtatacat gatgactgga   1440

actggagcag tcatcctaga ccccaggatg accctgggaa aggaagccat tgcatagaaa   1500

aatcaacaag gttaaaagga gtctaggtgt ctggtactgt agaacatcct gtcagtcgtg   1560

atctgacacc tttgtacttt caggtgagaa atagtctctc ccttgcttaa gtcactgtta   1620

ttgtaagttt tctagcacta acatcgaacc taataatgat ccaagaaacc cttgtggctg   1680

catacctaaa ccctgcttgc caaccaattt taacagtaat aaagctgact ttttgatttc   1740


<210>  9022
<211>  71
<212>  PRT
<213>  Homosapiens

<400>  9022

Met Pro Arg Pro Gly Pro Phe Ser Val Asp Pro Arg His His Leu Ser 
1               5                   10                  15      


Lys Gly Val Val Leu Phe Ser Pro Phe Pro Glu Ala Gln Asn Arg Arg 
            20                  25                  30          


Pro Cys Glu Asn Leu Ala Phe Cys Pro Val Leu Ser Ser Glu Leu Lys 
        35                  40                  45              


Glu Ala Ser Arg Gly Glu Ser Phe Thr Ser Leu Val Ser Gly Val Ser 
    50                  55                  60                  


His Ser Thr Leu Leu Ile Met 
65                  70      


<210>  9023
<211>  2063
<212>  DNA
<213>  Homosapiens

<400>  9023
aacatggctg cgcccgcact agggctggtg tgtggacgtt gccctgagct gggtctcgtc     60

ctcttgctgc tgctgctctc gctgctgtgt ggagcggcag ggagccagga ggccgggacc    120

ggtgcgggcg cggggtccct tgcgggttct tgcggctgcg gcacgcccca gcggcctggc    180

gcccagcggc aactcgcgca ctcaaagatg gtccccatcc ctgctggagt atttacaatg    240

ggcacagatg atcctcagat aaagcaggat ggggaagcac ctgcgaggag agttactatt    300

gatgcctttt acatggatgc ctatgaagtc agtaatactg aatttgagaa gtttgtgaac    360

tcaactggct atttgacaga ggctgagaag tttggcgact cctttgtctt tgaaggcatg    420

ttgagtgagc aagtgaagac caatattcaa caggcagttg cagctgctcc ctggtggtta    480

cctgtgaaag gcgctaactg gagacaccca gaagggcctg actctactat tctgcacagg    540

ccggatcatc cagttctcca tgtgtcctgg aatgatgcgg ttgcctactg cacttgggca    600

gggaagcggc tgcccacgga agctgagtgg gaatacagct gtcgaggagg cctgcataat    660

agacttttcc cctggggcaa caaactgcag cccaaaggcc agcattatgc caacatttgg    720

cagggcgagt ttccggtgac caacactggt gaggatggct tccaaggaac tgcgcctgtt    780

gatgccttcc ctcccaatgg ttatggctta tacaacatag tggggaacgc atgggaatgg    840

acttcagact ggtggactgt tcatcattct gttgaagaaa cgcttaaccc aaaaggtccc    900

ccttctggga aagaccgagt gaagaaaggt ggatcctaca tgtgccatag gtcttattgt    960

tacaggtatc gctgtgctgc tcggagccag aacacacctg atagctctgc ttcgaatctg   1020

ggattccgct gtgcagccga ccgcctgccc actatggact gacaaccaag gaaagtcttc   1080

cccagtccaa ggagcagtcg tgtctgacct acattgggct tttctcagaa ctttgaacga   1140

tcccatgcaa agaattccca ccctgaggtg ggttacatac ctgcccaatg gccaaaggaa   1200

ccgccttgtg agaccaaatt gctgacctgg gtcagtgcat gtgctttatg gtgtggtgca   1260

tctttggaga tcatcaccat attttacttt tgagagtctt taaagaggaa ggggagtgga   1320

gggaaccctg agctaggctt caggaggccc gcgtcctacg caggctctgc cacaggggtt   1380

agaccccagg tccgacgctt gaccttcctg ggcctcaagt gccctcccct atcaaatgaa   1440

gggatggaca gcatgacctc tgggtgtctc tccaactcac cagttctaaa aagggtatca   1500

gattctattg tgacttcata gtgagaattt attatagatt attttttagc tattttttcc   1560

atgtgtgaac cttgagtgat actaatcatg taaagtaaga gttctcttat gtattatttt   1620

cggaagaggg gtgtggtgac tcctttatat tcgtactgca ctttgttttt ccaaggaaat   1680

cagtgtcttt tacgttgtta tgatgaatcc cacatggggc cggtgatggt atgctgaagt   1740

tcagccgttg aacacatagg aatgtctgtg gggtgactct actgtgcttt atcttttaac   1800

attaagtgcc tttggttcag aggggcagtc ataagctctg tttccccctc tccccaaagc   1860

cttcagcgaa cgtgaaatgt gcgctaaacg gggaaacctg tttaattcta gatataggga   1920

aaaaggaacg aggaccttga atgagctata ttcagggtat ccggtatttt gtaataggga   1980

ataggaaacc ttgttggctg tggaatatcc gatgctttga atcatgcact gtgttgaata   2040

aacgtatctg ctaaatcagg ctt                                           2063


<210>  9024
<211>  352
<212>  PRT
<213>  Homosapiens

<400>  9024

Met Ala Ala Pro Ala Leu Gly Leu Val Cys Gly Arg Cys Pro Glu Leu 
1               5                   10                  15      


Gly Leu Val Leu Leu Leu Leu Leu Leu Ser Leu Leu Cys Gly Ala Ala 
            20                  25                  30          


Gly Ser Gln Glu Ala Gly Thr Gly Ala Gly Ala Gly Ser Leu Ala Gly 
        35                  40                  45              


Ser Cys Gly Cys Gly Thr Pro Gln Arg Pro Gly Ala Gln Arg Gln Leu 
    50                  55                  60                  


Ala His Ser Lys Met Val Pro Ile Pro Ala Gly Val Phe Thr Met Gly 
65                  70                  75                  80  


Thr Asp Asp Pro Gln Ile Lys Gln Asp Gly Glu Ala Pro Ala Arg Arg 
                85                  90                  95      


Val Thr Ile Asp Ala Phe Tyr Met Asp Ala Tyr Glu Val Ser Asn Thr 
            100                 105                 110         


Glu Phe Glu Lys Phe Val Asn Ser Thr Gly Tyr Leu Thr Glu Ala Glu 
        115                 120                 125             


Lys Phe Gly Asp Ser Phe Val Phe Glu Gly Met Leu Ser Glu Gln Val 
    130                 135                 140                 


Lys Thr Asn Ile Gln Gln Ala Val Ala Ala Ala Pro Trp Trp Leu Pro 
145                 150                 155                 160 


Val Lys Gly Ala Asn Trp Arg His Pro Glu Gly Pro Asp Ser Thr Ile 
                165                 170                 175     


Leu His Arg Pro Asp His Pro Val Leu His Val Ser Trp Asn Asp Ala 
            180                 185                 190         


Val Ala Tyr Cys Thr Trp Ala Gly Lys Arg Leu Pro Thr Glu Ala Glu 
        195                 200                 205             


Trp Glu Tyr Ser Cys Arg Gly Gly Leu His Asn Arg Leu Phe Pro Trp 
    210                 215                 220                 


Gly Asn Lys Leu Gln Pro Lys Gly Gln His Tyr Ala Asn Ile Trp Gln 
225                 230                 235                 240 


Gly Glu Phe Pro Val Thr Asn Thr Gly Glu Asp Gly Phe Gln Gly Thr 
                245                 250                 255     


Ala Pro Val Asp Ala Phe Pro Pro Asn Gly Tyr Gly Leu Tyr Asn Ile 
            260                 265                 270         


Val Gly Asn Ala Trp Glu Trp Thr Ser Asp Trp Trp Thr Val His His 
        275                 280                 285             


Ser Val Glu Glu Thr Leu Asn Pro Lys Gly Pro Pro Ser Gly Lys Asp 
    290                 295                 300                 


Arg Val Lys Lys Gly Gly Ser Tyr Met Cys His Arg Ser Tyr Cys Tyr 
305                 310                 315                 320 


Arg Tyr Arg Cys Ala Ala Arg Ser Gln Asn Thr Pro Asp Ser Ser Ala 
                325                 330                 335     


Ser Asn Leu Gly Phe Arg Cys Ala Ala Asp Arg Leu Pro Thr Met Asp 
            340                 345                 350         


<210>  9025
<211>  2151
<212>  DNA
<213>  Homosapiens

<400>  9025
cgggtcacat ggcccgcggg acaacatggc tgcgcccgca ctagggctgg tgtgtggacg     60

ttgccctgag ctgggtctcg tcctcttgct gctgctgctc tcgctgctgt gtggagcggc    120

agggagccag gaggccggga ccggtgcggg cgcggggtcc cttgcgggtt cttgcggctg    180

cggcacgccc cagcggcctg gcgcccatgg cagttcggca gccgctcacc gatactcgcg    240

ggaggctaac gctccgggcc ccgtacccgg agagcggcaa ctcgcgcact caaagatggt    300

ccccatccct gctggagtat ttacaatggg cacagatgat cctcagataa agcaggatgg    360

ggaagcacct gcgaggagag ttactattga tgccttttac atggatgcct atgaagtcag    420

taatactgaa tttgagaagt ttgtgaactc aactggctat ttgacagagg ctgagaagtt    480

tggcgactcc tttgtctttg aaggcatgtt gagtgagcaa gtgaagacca atattcaaca    540

ggcagttgca gctgctccct ggtggttacc tgtgaaaggc gctaactgga gacacccaga    600

agggcctgac tctactattc tgcacaggcc ggatcatcca gttctccatg tgtcctggaa    660

tgatgcggtt gcctactgca cttgggcagg gaagcggctg cccacggaag ctgagtggga    720

atacagctgt cgaggaggcc tgcataatag acttttcccc tggggcaaca aactgcagcc    780

caaaggccag cattatgcca acatttggca gggcgagttt ccggtgacca acactggtga    840

ggatggcttc caaggaactg cgcctgttga tgccttccct cccaatggtt atggcttata    900

caacatagtg gggaacgcat gggaatggac ttcagactgg tggactgttc atcattctgt    960

tgaagaaacg cttaacccaa aaggtccccc ttctgggaaa gaccgagtga agaaaggtgg   1020

atcctacatg tgccataggt cttattgtta caggtatcgc tgtgctgctc ggagccagaa   1080

cacacctgat agctctgctt cgaatctggg attccgctgt gcagccgacc gcctgcccac   1140

tatggactga caaccaagga aagtcttccc cagtccaagg agcagtcgtg tctgacctac   1200

attgggcttt tctcagaact ttgaacgatc ccatgcaaag aattcccacc ctgaggtggg   1260

ttacatacct gcccaatggc caaaggaacc gccttgtgag accaaattgc tgacctgggt   1320

cagtgcatgt gctttatggt gtggtgcatc tttggagatc atcaccatat tttacttttg   1380

agagtcttta aagaggaagg ggagtggagg gaaccctgag ctaggcttca ggaggcccgc   1440

gtcctacgca ggctctgcca caggggttag accccaggtc cgacgcttga ccttcctggg   1500

cctcaagtgc cctcccctat caaatgaagg gatggacagc atgacctctg ggtgtctctc   1560

caactcacca gttctaaaaa gggtatcaga ttctattgtg acttcatagt gagaatttat   1620

tatagattat tttttagcta ttttttccat gtgtgaacct tgagtgatac taatcatgta   1680

aagtaagagt tctcttatgt attattttcg gaagaggggt gtggtgactc ctttatattc   1740

gtactgcact ttgtttttcc aaggaaatca gtgtctttta cgttgttatg atgaatccca   1800

catggggccg gtgatggtat gctgaagttc agccgttgaa cacataggaa tgtctgtggg   1860

gtgactctac tgtgctttat cttttaacat taagtgcctt tggttcagag gggcagtcat   1920

aagctctgtt tccccctctc cccaaagcct tcagcgaacg tgaaatgtgc gctaaacggg   1980

gaaacctgtt taattctaga tatagggaaa aaggaacgag gaccttgaat gagctatatt   2040

cagggtatcc ggtattttgt aatagggaat aggaaacctt gttggctgtg gaatatccga   2100

tgctttgaat catgcactgt gttgaataaa cgtatctgct aaatcaggct t            2151


<210>  9026
<211>  374
<212>  PRT
<213>  Homosapiens

<400>  9026

Met Ala Ala Pro Ala Leu Gly Leu Val Cys Gly Arg Cys Pro Glu Leu 
1               5                   10                  15      


Gly Leu Val Leu Leu Leu Leu Leu Leu Ser Leu Leu Cys Gly Ala Ala 
            20                  25                  30          


Gly Ser Gln Glu Ala Gly Thr Gly Ala Gly Ala Gly Ser Leu Ala Gly 
        35                  40                  45              


Ser Cys Gly Cys Gly Thr Pro Gln Arg Pro Gly Ala His Gly Ser Ser 
    50                  55                  60                  


Ala Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Ala Pro Gly Pro Val 
65                  70                  75                  80  


Pro Gly Glu Arg Gln Leu Ala His Ser Lys Met Val Pro Ile Pro Ala 
                85                  90                  95      


Gly Val Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys Gln Asp Gly 
            100                 105                 110         


Glu Ala Pro Ala Arg Arg Val Thr Ile Asp Ala Phe Tyr Met Asp Ala 
        115                 120                 125             


Tyr Glu Val Ser Asn Thr Glu Phe Glu Lys Phe Val Asn Ser Thr Gly 
    130                 135                 140                 


Tyr Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Glu Gly 
145                 150                 155                 160 


Met Leu Ser Glu Gln Val Lys Thr Asn Ile Gln Gln Ala Val Ala Ala 
                165                 170                 175     


Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro Glu 
            180                 185                 190         


Gly Pro Asp Ser Thr Ile Leu His Arg Pro Asp His Pro Val Leu His 
        195                 200                 205             


Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys Arg 
    210                 215                 220                 


Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu His 
225                 230                 235                 240 


Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys Gly Gln His 
                245                 250                 255     


Tyr Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Thr Asn Thr Gly Glu 
            260                 265                 270         


Asp Gly Phe Gln Gly Thr Ala Pro Val Asp Ala Phe Pro Pro Asn Gly 
        275                 280                 285             


Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser Asp 
    290                 295                 300                 


Trp Trp Thr Val His His Ser Val Glu Glu Thr Leu Asn Pro Lys Gly 
305                 310                 315                 320 


Pro Pro Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser Tyr Met Cys 
                325                 330                 335     


His Arg Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser Gln Asn 
            340                 345                 350         


Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala Ala Asp 
        355                 360                 365             


Arg Leu Pro Thr Met Asp 
    370                 


<210>  9027
<211>  1820
<212>  DNA
<213>  Homosapiens

<400>  9027
atgcccgcac tgacatttgg tctcatggct tctattcttc aaggccaaag taagagaagc     60

caaccaaaag ctcaatattt ccaaggcaaa gagctgcaga tttggttggt gattagccta    120

cctttccact tcactgaaaa taaggctgca ggggaaaagt acaaaggtca gcttcagcct    180

gaacaggatg ctggagagca gaatattagt cctccttgta aatatctctt aaaacgacac    240

tggatacaac gcagggtggc gcaaccagtt agaaaagagt ctgtggacca gtttttcctt    300

gctgtacagc taattctgaa aaggggaact gggcctaatc cttggctcta tgagcaccca    360

cacagccatg ggaggggcgt cctgcgaggc tttcaggctg ctgagcctgt tccttggctg    420

gggtcggtag ggcttggagc cagccgttca aagtcacccc tgggaagcgc ccgcaaccct    480

tggggacgcc tctcctccgg ctgcccccct tccctggaat ccaggtgtca ctggggccgg    540

ggaggggcta ggagctcgga tttctgcttt gggaagtttt tacaagccca ccctccccct    600

gccttggttc cccgagccaa gaatttcaga aatccggggc acaaaaacgc cagtgtttgc    660

ggtcaaggat taaaggcgcg aggtgtcttt atttaatctg ctccgccctg ctcgggtttg    720

cacgagaaac caagcctggg agcgacggtc cacgcaagcg gagacacagc attatcccct    780

ggtcactgga cgctggggtc tagtgcctaa tacgttaagc tgcttctccc catcatcaag    840

aaactgccgc atctgccata taaaggagat gtttctcatt cgcccccact catctcttcc    900

cccatgaaaa cctcttccat tttcaaagga tcttcggctc tacttttcaa gcaaattcaa    960

caaatcagtg tatgcctgtg taactggtaa atagtgaagg gtaattattt catgtgcttc   1020

taactcagaa acaatggaat attaacagcg gttttctgaa gatccagttg gacaattttc   1080

attttcatca tataatggac atttatctcc tacctgcatt atccactgtc ttccctcgga   1140

gaccacaaat ttcactgaag gcagcatcta tgtcttattc atgcttgtgc tctctacctc   1200

ccctgaccca gaaggactta ttcttctttc tgcacatttt agtagatgtg ttaaaaaaaa   1260

aaaaaaaaag tttgttaaga agatgtttta atggaaggtg tgtcaggcat atggcaggat   1320

acatgaccat atttttggag catgcaacac ctcgtagccc atctctatca tagcctattt   1380

tctccgcctg tatgtatgga taatcctatt caacattttt aaggtctaga agctgctagg   1440

tcactagaaa gtaattttgc tatgatgtga agaggttctc tatgatgatg tatgactgat   1500

aaattatgat gattaatgtc agaatataag ggtcactgcc taactcattc tctgttatca   1560

gtagagggaa aggagctgct ttctcttcac tatttttttc tagaagaatt ttctatccct   1620

gtgttttcca gtatagtgac tactagccat ttaggcacgt aagatgtggc tagttctgag   1680

atgtgaaata gatgttaaca cattgaattt caaagactta gtacaaaaaa aagcaaaata   1740

tcttaatttg tatagtgatt acatgttgaa gtggtaatat tttggatatt tgtgttaaat   1800

aaaatagatt attagaattt                                               1820


<210>  9028
<211>  231
<212>  PRT
<213>  Homosapiens

<400>  9028

Met Pro Ala Leu Thr Phe Gly Leu Met Ala Ser Ile Leu Gln Gly Gln 
1               5                   10                  15      


Ser Lys Arg Ser Gln Pro Lys Ala Gln Tyr Phe Gln Gly Lys Glu Leu 
            20                  25                  30          


Gln Ile Trp Leu Val Ile Ser Leu Pro Phe His Phe Thr Glu Asn Lys 
        35                  40                  45              


Ala Ala Gly Glu Lys Tyr Lys Gly Gln Leu Gln Pro Glu Gln Asp Ala 
    50                  55                  60                  


Gly Glu Gln Asn Ile Ser Pro Pro Cys Lys Tyr Leu Leu Lys Arg His 
65                  70                  75                  80  


Trp Ile Gln Arg Arg Val Ala Gln Pro Val Arg Lys Glu Ser Val Asp 
                85                  90                  95      


Gln Phe Phe Leu Ala Val Gln Leu Ile Leu Lys Arg Gly Thr Gly Pro 
            100                 105                 110         


Asn Pro Trp Leu Tyr Glu His Pro His Ser His Gly Arg Gly Val Leu 
        115                 120                 125             


Arg Gly Phe Gln Ala Ala Glu Pro Val Pro Trp Leu Gly Ser Val Gly 
    130                 135                 140                 


Leu Gly Ala Ser Arg Ser Lys Ser Pro Leu Gly Ser Ala Arg Asn Pro 
145                 150                 155                 160 


Trp Gly Arg Leu Ser Ser Gly Cys Pro Pro Ser Leu Glu Ser Arg Cys 
                165                 170                 175     


His Trp Gly Arg Gly Gly Ala Arg Ser Ser Asp Phe Cys Phe Gly Lys 
            180                 185                 190         


Phe Leu Gln Ala His Pro Pro Pro Ala Leu Val Pro Arg Ala Lys Asn 
        195                 200                 205             


Phe Arg Asn Pro Gly His Lys Asn Ala Ser Val Cys Gly Gln Gly Leu 
    210                 215                 220                 


Lys Ala Arg Gly Val Phe Ile 
225                 230     


<210>  9029
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9029
gtggatgtgc tgctgaagcg tttcctcaag ctcgctgggg tgggaggaga ggaggaggag     60

gaggtggtgg tggaggagga ggcagggggt ggagagagag aaagcgcacg ccgagaggag    120

gtgtgggtgt tccgcttcca tcctaacgga acgagctccc tcttcgcgga catgggatta    180

cccagcggct gctaacccct ctcctcgccc tgctccccca aaccggcgtg gctccccggg    240

caccaaggag ctgactacag aggagcagga tttgcacccc tcgctgggct tgctttggca    300

acagagtgcc tgacccaggt caggattttc aagaaagaca tgtctgacaa aatgtctagc    360

ttcctacata ttggagacat ttgttctctg tacgcggagg gatcgacaaa tggatttatt    420

agcaccttgg gcctggttga tgatcgttgt gttgtacagc cagaaaccgg ggaccttaac    480

aatccaccta agaaattcag agactgcctc tttaagctat gtcccatgaa ccgctactct    540

gcccaaaagc agttctggaa agccgctaag cctggggcca acagcaccac agacgcagtg    600

ctactcaaca aactgcacca cgctgcagac ttggaaaaga agcagaatga gacagaaaac    660

aggaaattgc tggggaccgt aatccagtat ggcaatgtga tccagctcct gcatttgaaa    720

agtaataaat acctaacagt gaataagagg cttcctgctc tgttggagaa gaatgccatg    780

agagtcacat tggacgaggc tggaaatgaa gggtcctggt tttatattca gccattctac    840

aagctgcgat ccattggaga cagcgtggtc ataggtgaca aggtggttct gaaccccgtc    900

aatgctggtc agcccctaca tgctagcagc catcaactgg tagataaccc aggctgcaat    960

gaggtcaatt ccgtcaactg caatacaagc tggaaaatag tccttttcat gaaatggagt   1020

gataacaaag acgacatatt aaaggggggt gacgtggtga ggctgtttca tgctgagcag   1080

gagaagtttc tcacctgtga cgaacacagg aagaagcagc acgtcttcct gagaaccacg   1140

ggccggcagt cggccacatc tgccaccagt tcaaaagccc tgtgggaggt ggaggtggtc   1200

cagcatgacc catgtcgggg cggagcaggg tattggaaca gccttttccg tttcaagcat   1260

ctggccacgg ggcattactt ggcagcagag gtagaccctg actttgagga agaatgcctg   1320

gagtttcagc cctcagtgga ccctgatcag gacgcctctc gaagtaggtt gcggaatgcc   1380

caagaaaaga tggtatactc cctggtctct gtgcctgaag gcaatgacat ctcctccatt   1440

ttcgagctag atcccaccac tctgcgtgga ggtgacagcc ttgtcccaag gaactcttat   1500

gttcggctca gacacctatg tactaatacc tgggttcaca gcacaaatat tcctattgac   1560

aaggaagaag aaaagcccgt gatgctgaaa attggcacct ctcctgtgaa ggaggataag   1620

gaagcatttg ccatagttcc ggtttctcct gctgaagttc gggacctgga ctttgccaat   1680

gatgccagca aggtgctggg ctccattgct gggaagctag agaagggcac catcacccag   1740

aatgaaagga ggtctgtaac caagctgcta gaagatttgg tttacttcgt cactggtgga   1800

actaattctg gtcaagatgt tctcgaagtt gtcttctcca agcccaacag agaacggcag   1860

aaactgatga gagaacagaa tattctcaag cagatcttca agttgttaca agccccattc   1920

acagactgcg gtgatggccc aatgcttcgg ctggaagagc tcggggacca gcggcacgct   1980

cctttcagac acatctgccg gctctgctac agggtgctga gacactcgca gcaagactac   2040

aggaagaacc aggagtatat agccaagcag tttggcttca tgcagaagca gattggctat   2100

gatgtgttgg ctgaagacac tatcactgcc ctgctccaca ataatcggaa actcctggaa   2160

aaacacatta ccgcggcaga gattgacaca tttgtcagcc tggtgcgaaa gaacagggag   2220

cccagattct tagattacct ctccgacctc tgtgtctcca tgaacaaatc aattccagtg   2280

acccaggaac tgatatgtaa agctgtgctg aaccccacca acgctgacat cctgattgag   2340

accaagttgg ttctttctcg ttttgaattt gaaggtgtct cttccactgg agagaatgct   2400

ctggaggcag gagaagacga ggaagaggtg tggctgtttt ggagggacag caacaaagag   2460

attcgcagca agagtgtgag ggaattggct caggatgcta aagaagggca gaaggaggac   2520

cgagacgttc tcagctacta cagatatcag ctgaacctct ttgcgaggat gtgtctggac   2580

cgccaatacc tggccatcaa cgaaatctca ggccagctgg atgtcgatct cattctccgc   2640

tgcatgtctg acgagaacct gccctatgac ctcagggcgt ccttctgccg cctcatgctt   2700

cacatgcatg tggaccgaga tccccaggaa caagtcaccc ccgtgaaata tgcccgcctc   2760

tggtcggaga ttccctcgga gatcgccatt gacgactatg atagtagtgg agcttccaaa   2820

gatgaaatta aggagagatt tgctcagacc atggagtttg tggaggagta tttaagagat   2880

gtggtttgtc agaggttccc tttctctgat aaagagaaga ataagcttac gtttgaggtt   2940

gtaaatttag ctaggaatct catatacttt ggtttctaca acttctctga ccttctacga   3000

ttaactaaga tccttctggc catattggac tgtgtacatg tgacaacaat cttccccatt   3060

agcaagatgg cgaaaggaga agagaataaa ggcagtaacg tgatgagatc tattcatggc   3120

gtgggagagc tgatgaccca ggtggtgctc cggggaggag gctttttgcc catgactccc   3180

atggctgctg cccctgaagg caatgtgaag caggcagagc ctgagaagga ggacatcatg   3240

gtcatggaca ccaagctgaa gatcattgag atactccagt ttattttgaa tgtgaggttg   3300

gattatagga tctcctgcct cctgtgtata tttaagcgag agtttgatga aagcaattcc   3360

cagacttcag aaacatcctc cggaaacagc agccaagaag ggccaagtaa tgtaccaggt   3420

gctcttgact ttgaacacat tgaagaacaa gcagaaggca tctttggagg aaggaaagag   3480

aacaccccac tggacttgga tgaccacggc ggcagaacct ttctccgtgt cctgctccac   3540

ttgacgatgc atgactaccc acccctggtg tcaggggccc tgcagctcct cttccggcac   3600

ttcagccaga ggcaggaggt gctccaggcc ttcaaacagg ttcaactgct ggttaccagc   3660

caagatgtgg acaactacaa acagatcaaa caagacttgg atcaactgag gtccatcgtg   3720

gaaaagtcag agctttgggt gtacaaaggg cagggccccg atgagactat ggatggtgca   3780

tctggagaaa atgaacataa gaaaacggag gagggaaata acaagccaca aaagcatgaa   3840

agcaccagca gctacaacta cagagtggtc aaagagattt tgattcggct tagcaaactc   3900

tgtgttcaag agagtgcctc agtgagaaag agcaggaagc agcaacagcg tctgctccgg   3960

aacatgggcg cgcacgccgt ggtgctggag ctgctgcaga ttccctatga gaaggccgaa   4020

gataccaaga tgcaagagat aatgaggttg gctcatgaat ttttgcagaa tttctgcgca   4080

ggcaaccagc agaatcaagc tttgctacat aaacacataa acctgtttct caacccaggg   4140

atcctggagg cagtaaccat gcagcacatc ttcatgaaca atttccagct ttgcagtgag   4200

atcaacgaga gagttgttca gcacttcgtt cactgcatag agactcacgg tcggaatgtc   4260

cagtatataa agttcttaca gacaattgtc aaggcagaag ggaaatttat taaaaaatgc   4320

caagacatgg ttatggccga gctggtcaat tcgggagagg atgtcctcgt gttctacaac   4380

gacagagcct ctttccagac tctgatccag atgatgcggt cagaacggga tcggatggat   4440

gagaacagcc ctctcatgta ccacatccac ttggtcgagc tcctggctgt gtgcacggag   4500

ggtaagaatg tctacacaga gatcaagtgc aactccctgc tcccgctgga tgacatcgtt   4560

cgcgtggtga cccacgagga ctgcatccct gaggttaaaa ttgcatacat taacttcctg   4620

aatcactgct atgtggatac agaggtggaa atgaaggaga tttataccag caatcacatg   4680

tggaaattgt ttgagaattt ccttgtagac atctgcaggg cctgtaacaa cactagtgac   4740

aggaaacatg cagactcgat tttggagaag tatgtcaccg aaatcgtcat gagtattgtt   4800

actactttct tcagctctcc cttctcagac cagagtacga ctttgcagac tcgccagcct   4860

gtctttgtgc aactgctgca aggcgtgttc agggtttacc actgcaactg gttaatgcca   4920

agccaaaaag cctccgtgga gagctgtatt cgggtgctgt ctgatgtagc caagagccgg   4980

gccattgcca ttcccgtgga cctggacagc caagtcaaca acctctttct caagtcccac   5040

agcattgtgc agaaaacagc catgaactgg cggctctcag cccgcaatgc cgcacgcagg   5100

gactctgttc tggcagcttc cagagactac cggaatatca ttgagagatt gcaggacatc   5160

gtctccgcgc tggaggaccg tctcaggccc ctggtgcagg cagagttatc tgtgctcgtg   5220

gatgttctcc acagacccga gctgcttttc ccagagaaca cagacgccag aaggaaatgt   5280

gaaagtggcg gtttcatttg caagttaata aagcatacaa aacagctgct agaagaaaat   5340

gaagagaagc tctgcattaa ggtcctacag accctgaggg aaatgatgac caaagataga   5400

ggctatggag aaaagggtga ggcgctcagg caagttctgg tcaaccgtta ctatggaaac   5460

gtcagacctt cgggacgaag agagagcctt accagctttg gcaatggccc actgtcagca   5520

ggaggacccg gcaagcccgg gggaggaggg ggaggttccg gatccagctc tatgagcagg   5580

ggtgagatga gtctggccga ggttcagtgt caccttgaca aggagggggc ttccaatcta   5640

gttatcgacc tcatcatgaa cgcatccagt gaccgagtgt tccatgaaag cattctcctg   5700

gccattgccc ttctggaagg aggcaacacc accatccagc actccttttt ctgtcgcttg   5760

acagaagata agaagtcaga gaaattcttt aaggtgtttt atgaccggat gaaggtggcc   5820

cagcaagaaa tcaaagcaac agtgacagtg aacaccagtg acttgggaaa taaaaagaaa   5880

gacgatgagg tagacaggga tgccccatca cggaaaaaag ctaaagagcc cacaacacag   5940

ataacagaag aggtccggga tcagctcctg gaggcctccg ctgccaccag gaaagccttc   6000

accactttca ggagggaggc tgatcccgac gaccactacc agcctggaga gggcacccag   6060

gccactgccg acaaggccaa ggacgacctg gagatgagcg cggtcatcac catcatgcag   6120

cccatcctcc gcttccttca gctcctgtgt gaaaaccaca accgagacct gcagaacttc   6180

ctccgttgcc aaaataacaa gaccaactac aatttggtat gtgagaccct gcagtttctg   6240

gactgtattt gtggaagcac aactggaggc cttggtcttc tgggcttgta tataaatgaa   6300

aagaatgtag cgcttatcaa ccaaaccctg gaaagtctga ccgaatactg tcaaggacct   6360

tgccatgaga accagaactg catagccacc catgaatcca atggcattga catcatcaca   6420

gccctgatcc tcaatgatat caatcctttg ggaaagaaga ggatggacct tgtgttagaa   6480

ctgaagaaca atgcctcgaa gttgctcctg gccatcatgg aaagcaggca cgacagtgaa   6540

aacgcagaga ggatacttta taacatgagg cccaaggaac tggtggaagt gatcaagaaa   6600

gcctacatgc aaggtgaagt ggaatttgag gatggagaaa acggtgagga tggggcggcg   6660

tcccccagga acgtggggca caacatctac atattagccc atcagttggc tcggcataac   6720

aaagaacttc agagcatgct gaaacctggt ggccaagtgg acggagatga agccctggag   6780

ttttatgcca agcacacggc gcagatagag attgtcagat tagaccgaac aatggaacag   6840

atagtctttc ccgtgcccag catatgtgaa ttcctaacca aggagtcaaa actacgaatt   6900

tactatacta cagagagaga cgaacaaggc agcaaaatca atgatttctt tctgcggtct   6960

gaagacctct tcaatgaaat gaattggcag aagaaactga gagcccagcc cgtgttgtac   7020

tggtgtgccc gcaacatgtc tttctggagc agcatttcgt ttaacctggc cgtcctgatg   7080

aacctgctgg tggcgttttt ctacccgttt aagggagtcc gaggaggaac cctggagccc   7140

cactggtcgg gactcctgtg gacagccatg ctcatctctc tggccatcgt cattgccctc   7200

cccaagcccc atggcatccg ggccttaatt gcctccacaa ttctacgact gatattttca   7260

gtcgggttac aacccacgtt gtttcttctg ggcgctttca atgtatgcaa taaaatcatc   7320

tttctaatga gctttgtggg caactgtggg acattcacaa gaggctaccg agccatggtt   7380

ctggatgttg agttcctcta tcatttgttg tatctggtga tctgtgccat ggggctcttt   7440

gtccatgaat tcttctacag tctgctgctt tttgatttag tgtacagaga agagactttg   7500

cttaatgtca ttaaaagtgt cactcgcaat ggacggtcca tcatcctgac agcagttctg   7560

gctctgatcc tcgtttacct gttctcaata gtgggctatc ttttcttcaa ggatgacttt   7620

atcttggaag tagataggct gcccaatgaa acagctgttc cagaaaccgg cgagagtttg   7680

gcaagcgagt tcctgttctc cgatgtgtgt agggtggaga gtggggagaa ctgctcctct   7740

cctgcaccca gagaagagct ggtccctgca gaagagacgg aacaggataa agagcacaca   7800

tgtgagacgc tgctgatgtg cattgtcact gtgctgagtc acgggctgcg gagcgggggt   7860

ggagtaggag atgtactcag gaagccgtcc aaagaggaac ccctgtttgc tgctagagtt   7920

atttatgacc tcttgttctt cttcatggtc atcatcattg ttcttaacct gatttttggg   7980

gttatcattg acacttttgc tgacctgagg agtgagaagc agaagaagga agagatcttg   8040

aagaccacgt gctttatctg tggcttggaa agagacaagt ttgacaacaa gactgtcacc   8100

tttgaagagc acatcaagga agaacacaac atgtggcact atctgtgctt catcgtcctg   8160

gtgaaagtaa aggactccac cgaatatact gg                                 8192


<210>  9030
<211>  2710
<212>  PRT
<213>  Homosapiens

<400>  9030

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Phe Glu Glu Glu Cys Leu Glu Phe Gln Pro Ser Val Asp Pro Asp 
                325                 330                 335     


Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met Val 
            340                 345                 350         


Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile Phe 
        355                 360                 365             


Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro Arg 
    370                 375                 380                 


Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val His 
385                 390                 395                 400 


Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met Leu 
                405                 410                 415     


Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala Ile 
            420                 425                 430         


Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn Asp 
        435                 440                 445             


Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly Thr 
    450                 455                 460                 


Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp Leu 
465                 470                 475                 480 


Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu Glu 
                485                 490                 495     


Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu 
            500                 505                 510         


Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe Thr 
        515                 520                 525             


Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp Gln 
    530                 535                 540                 


Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys 
                565                 570                 575     


Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg Lys 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala Val 
                645                 650                 655     


Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val Leu 
            660                 665                 670         


Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala Leu 
        675                 680                 685             


Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp Ser 
    690                 695                 700                 


Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp Ala 
705                 710                 715                 720 


Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg Tyr 
                725                 730                 735     


Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala 
            740                 745                 750         


Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg Cys 
        755                 760                 765             


Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys Arg 
    770                 775                 780                 


Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val Thr 
785                 790                 795                 800 


Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile Ala 
                805                 810                 815     


Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys Glu 
            820                 825                 830         


Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp Val 
        835                 840                 845             


Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu Thr 
    850                 855                 860                 


Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr 
865                 870                 875                 880 


Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile Leu 
                885                 890                 895     


Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala Lys 
            900                 905                 910         


Gly Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly Val 
        915                 920                 925             


Gly Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu Pro 
    930                 935                 940                 


Met Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala Glu 
945                 950                 955                 960 


Pro Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile Ile 
                965                 970                 975     


Glu Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser 
            980                 985                 990         


Cys Leu Leu Cys Ile Phe Lys Arg  Glu Phe Asp Glu Ser  Asn Ser Gln 
        995                 1000                 1005             


Thr Ser  Glu Thr Ser Ser Gly  Asn Ser Ser Gln Glu  Gly Pro Ser 
    1010                 1015                 1020             


Asn Val  Pro Gly Ala Leu Asp  Phe Glu His Ile Glu  Glu Gln Ala 
    1025                 1030                 1035             


Glu Gly  Ile Phe Gly Gly Arg  Lys Glu Asn Thr Pro  Leu Asp Leu 
    1040                 1045                 1050             


Asp Asp  His Gly Gly Arg Thr  Phe Leu Arg Val Leu  Leu His Leu 
    1055                 1060                 1065             


Thr Met  His Asp Tyr Pro Pro  Leu Val Ser Gly Ala  Leu Gln Leu 
    1070                 1075                 1080             


Leu Phe  Arg His Phe Ser Gln  Arg Gln Glu Val Leu  Gln Ala Phe 
    1085                 1090                 1095             


Lys Gln  Val Gln Leu Leu Val  Thr Ser Gln Asp Val  Asp Asn Tyr 
    1100                 1105                 1110             


Lys Gln  Ile Lys Gln Asp Leu  Asp Gln Leu Arg Ser  Ile Val Glu 
    1115                 1120                 1125             


Lys Ser  Glu Leu Trp Val Tyr  Lys Gly Gln Gly Pro  Asp Glu Thr 
    1130                 1135                 1140             


Met Asp  Gly Ala Ser Gly Glu  Asn Glu His Lys Lys  Thr Glu Glu 
    1145                 1150                 1155             


Gly Asn  Asn Lys Pro Gln Lys  His Glu Ser Thr Ser  Ser Tyr Asn 
    1160                 1165                 1170             


Tyr Arg  Val Val Lys Glu Ile  Leu Ile Arg Leu Ser  Lys Leu Cys 
    1175                 1180                 1185             


Val Gln  Glu Ser Ala Ser Val  Arg Lys Ser Arg Lys  Gln Gln Gln 
    1190                 1195                 1200             


Arg Leu  Leu Arg Asn Met Gly  Ala His Ala Val Val  Leu Glu Leu 
    1205                 1210                 1215             


Leu Gln  Ile Pro Tyr Glu Lys  Ala Glu Asp Thr Lys  Met Gln Glu 
    1220                 1225                 1230             


Ile Met  Arg Leu Ala His Glu  Phe Leu Gln Asn Phe  Cys Ala Gly 
    1235                 1240                 1245             


Asn Gln  Gln Asn Gln Ala Leu  Leu His Lys His Ile  Asn Leu Phe 
    1250                 1255                 1260             


Leu Asn  Pro Gly Ile Leu Glu  Ala Val Thr Met Gln  His Ile Phe 
    1265                 1270                 1275             


Met Asn  Asn Phe Gln Leu Cys  Ser Glu Ile Asn Glu  Arg Val Val 
    1280                 1285                 1290             


Gln His  Phe Val His Cys Ile  Glu Thr His Gly Arg  Asn Val Gln 
    1295                 1300                 1305             


Tyr Ile  Lys Phe Leu Gln Thr  Ile Val Lys Ala Glu  Gly Lys Phe 
    1310                 1315                 1320             


Ile Lys  Lys Cys Gln Asp Met  Val Met Ala Glu Leu  Val Asn Ser 
    1325                 1330                 1335             


Gly Glu  Asp Val Leu Val Phe  Tyr Asn Asp Arg Ala  Ser Phe Gln 
    1340                 1345                 1350             


Thr Leu  Ile Gln Met Met Arg  Ser Glu Arg Asp Arg  Met Asp Glu 
    1355                 1360                 1365             


Asn Ser  Pro Leu Met Tyr His  Ile His Leu Val Glu  Leu Leu Ala 
    1370                 1375                 1380             


Val Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1385                 1390                 1395             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Glu 
    1400                 1405                 1410             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Ile Asn  Phe Leu Asn 
    1415                 1420                 1425             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1430                 1435                 1440             


Ser Asn  His Met Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Ile 
    1445                 1450                 1455             


Cys Arg  Ala Cys Asn Asn Thr  Ser Asp Arg Lys His  Ala Asp Ser 
    1460                 1465                 1470             


Ile Leu  Glu Lys Tyr Val Thr  Glu Ile Val Met Ser  Ile Val Thr 
    1475                 1480                 1485             


Thr Phe  Phe Ser Ser Pro Phe  Ser Asp Gln Ser Thr  Thr Leu Gln 
    1490                 1495                 1500             


Thr Arg  Gln Pro Val Phe Val  Gln Leu Leu Gln Gly  Val Phe Arg 
    1505                 1510                 1515             


Val Tyr  His Cys Asn Trp Leu  Met Pro Ser Gln Lys  Ala Ser Val 
    1520                 1525                 1530             


Glu Ser  Cys Ile Arg Val Leu  Ser Asp Val Ala Lys  Ser Arg Ala 
    1535                 1540                 1545             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Asn Leu Phe 
    1550                 1555                 1560             


Leu Lys  Ser His Ser Ile Val  Gln Lys Thr Ala Met  Asn Trp Arg 
    1565                 1570                 1575             


Leu Ser  Ala Arg Asn Ala Ala  Arg Arg Asp Ser Val  Leu Ala Ala 
    1580                 1585                 1590             


Ser Arg  Asp Tyr Arg Asn Ile  Ile Glu Arg Leu Gln  Asp Ile Val 
    1595                 1600                 1605             


Ser Ala  Leu Glu Asp Arg Leu  Arg Pro Leu Val Gln  Ala Glu Leu 
    1610                 1615                 1620             


Ser Val  Leu Val Asp Val Leu  His Arg Pro Glu Leu  Leu Phe Pro 
    1625                 1630                 1635             


Glu Asn  Thr Asp Ala Arg Arg  Lys Cys Glu Ser Gly  Gly Phe Ile 
    1640                 1645                 1650             


Cys Lys  Leu Ile Lys His Thr  Lys Gln Leu Leu Glu  Glu Asn Glu 
    1655                 1660                 1665             


Glu Lys  Leu Cys Ile Lys Val  Leu Gln Thr Leu Arg  Glu Met Met 
    1670                 1675                 1680             


Thr Lys  Asp Arg Gly Tyr Gly  Glu Lys Gly Glu Ala  Leu Arg Gln 
    1685                 1690                 1695             


Val Leu  Val Asn Arg Tyr Tyr  Gly Asn Val Arg Pro  Ser Gly Arg 
    1700                 1705                 1710             


Arg Glu  Ser Leu Thr Ser Phe  Gly Asn Gly Pro Leu  Ser Ala Gly 
    1715                 1720                 1725             


Gly Pro  Gly Lys Pro Gly Gly  Gly Gly Gly Gly Ser  Gly Ser Ser 
    1730                 1735                 1740             


Ser Met  Ser Arg Gly Glu Met  Ser Leu Ala Glu Val  Gln Cys His 
    1745                 1750                 1755             


Leu Asp  Lys Glu Gly Ala Ser  Asn Leu Val Ile Asp  Leu Ile Met 
    1760                 1765                 1770             


Asn Ala  Ser Ser Asp Arg Val  Phe His Glu Ser Ile  Leu Leu Ala 
    1775                 1780                 1785             


Ile Ala  Leu Leu Glu Gly Gly  Asn Thr Thr Ile Gln  His Ser Phe 
    1790                 1795                 1800             


Phe Cys  Arg Leu Thr Glu Asp  Lys Lys Ser Glu Lys  Phe Phe Lys 
    1805                 1810                 1815             


Val Phe  Tyr Asp Arg Met Lys  Val Ala Gln Gln Glu  Ile Lys Ala 
    1820                 1825                 1830             


Thr Val  Thr Val Asn Thr Ser  Asp Leu Gly Asn Lys  Lys Lys Asp 
    1835                 1840                 1845             


Asp Glu  Val Asp Arg Asp Ala  Pro Ser Arg Lys Lys  Ala Lys Glu 
    1850                 1855                 1860             


Pro Thr  Thr Gln Ile Thr Glu  Glu Val Arg Asp Gln  Leu Leu Glu 
    1865                 1870                 1875             


Ala Ser  Ala Ala Thr Arg Lys  Ala Phe Thr Thr Phe  Arg Arg Glu 
    1880                 1885                 1890             


Ala Asp  Pro Asp Asp His Tyr  Gln Pro Gly Glu Gly  Thr Gln Ala 
    1895                 1900                 1905             


Thr Ala  Asp Lys Ala Lys Asp  Asp Leu Glu Met Ser  Ala Val Ile 
    1910                 1915                 1920             


Thr Ile  Met Gln Pro Ile Leu  Arg Phe Leu Gln Leu  Leu Cys Glu 
    1925                 1930                 1935             


Asn His  Asn Arg Asp Leu Gln  Asn Phe Leu Arg Cys  Gln Asn Asn 
    1940                 1945                 1950             


Lys Thr  Asn Tyr Asn Leu Val  Cys Glu Thr Leu Gln  Phe Leu Asp 
    1955                 1960                 1965             


Cys Ile  Cys Gly Ser Thr Thr  Gly Gly Leu Gly Leu  Leu Gly Leu 
    1970                 1975                 1980             


Tyr Ile  Asn Glu Lys Asn Val  Ala Leu Ile Asn Gln  Thr Leu Glu 
    1985                 1990                 1995             


Ser Leu  Thr Glu Tyr Cys Gln  Gly Pro Cys His Glu  Asn Gln Asn 
    2000                 2005                 2010             


Cys Ile  Ala Thr His Glu Ser  Asn Gly Ile Asp Ile  Ile Thr Ala 
    2015                 2020                 2025             


Leu Ile  Leu Asn Asp Ile Asn  Pro Leu Gly Lys Lys  Arg Met Asp 
    2030                 2035                 2040             


Leu Val  Leu Glu Leu Lys Asn  Asn Ala Ser Lys Leu  Leu Leu Ala 
    2045                 2050                 2055             


Ile Met  Glu Ser Arg His Asp  Ser Glu Asn Ala Glu  Arg Ile Leu 
    2060                 2065                 2070             


Tyr Asn  Met Arg Pro Lys Glu  Leu Val Glu Val Ile  Lys Lys Ala 
    2075                 2080                 2085             


Tyr Met  Gln Gly Glu Val Glu  Phe Glu Asp Gly Glu  Asn Gly Glu 
    2090                 2095                 2100             


Asp Gly  Ala Ala Ser Pro Arg  Asn Val Gly His Asn  Ile Tyr Ile 
    2105                 2110                 2115             


Leu Ala  His Gln Leu Ala Arg  His Asn Lys Glu Leu  Gln Ser Met 
    2120                 2125                 2130             


Leu Lys  Pro Gly Gly Gln Val  Asp Gly Asp Glu Ala  Leu Glu Phe 
    2135                 2140                 2145             


Tyr Ala  Lys His Thr Ala Gln  Ile Glu Ile Val Arg  Leu Asp Arg 
    2150                 2155                 2160             


Thr Met  Glu Gln Ile Val Phe  Pro Val Pro Ser Ile  Cys Glu Phe 
    2165                 2170                 2175             


Leu Thr  Lys Glu Ser Lys Leu  Arg Ile Tyr Tyr Thr  Thr Glu Arg 
    2180                 2185                 2190             


Asp Glu  Gln Gly Ser Lys Ile  Asn Asp Phe Phe Leu  Arg Ser Glu 
    2195                 2200                 2205             


Asp Leu  Phe Asn Glu Met Asn  Trp Gln Lys Lys Leu  Arg Ala Gln 
    2210                 2215                 2220             


Pro Val  Leu Tyr Trp Cys Ala  Arg Asn Met Ser Phe  Trp Ser Ser 
    2225                 2230                 2235             


Ile Ser  Phe Asn Leu Ala Val  Leu Met Asn Leu Leu  Val Ala Phe 
    2240                 2245                 2250             


Phe Tyr  Pro Phe Lys Gly Val  Arg Gly Gly Thr Leu  Glu Pro His 
    2255                 2260                 2265             


Trp Ser  Gly Leu Leu Trp Thr  Ala Met Leu Ile Ser  Leu Ala Ile 
    2270                 2275                 2280             


Val Ile  Ala Leu Pro Lys Pro  His Gly Ile Arg Ala  Leu Ile Ala 
    2285                 2290                 2295             


Ser Thr  Ile Leu Arg Leu Ile  Phe Ser Val Gly Leu  Gln Pro Thr 
    2300                 2305                 2310             


Leu Phe  Leu Leu Gly Ala Phe  Asn Val Cys Asn Lys  Ile Ile Phe 
    2315                 2320                 2325             


Leu Met  Ser Phe Val Gly Asn  Cys Gly Thr Phe Thr  Arg Gly Tyr 
    2330                 2335                 2340             


Arg Ala  Met Val Leu Asp Val  Glu Phe Leu Tyr His  Leu Leu Tyr 
    2345                 2350                 2355             


Leu Val  Ile Cys Ala Met Gly  Leu Phe Val His Glu  Phe Phe Tyr 
    2360                 2365                 2370             


Ser Leu  Leu Leu Phe Asp Leu  Val Tyr Arg Glu Glu  Thr Leu Leu 
    2375                 2380                 2385             


Asn Val  Ile Lys Ser Val Thr  Arg Asn Gly Arg Ser  Ile Ile Leu 
    2390                 2395                 2400             


Thr Ala  Val Leu Ala Leu Ile  Leu Val Tyr Leu Phe  Ser Ile Val 
    2405                 2410                 2415             


Gly Tyr  Leu Phe Phe Lys Asp  Asp Phe Ile Leu Glu  Val Asp Arg 
    2420                 2425                 2430             


Leu Pro  Asn Glu Thr Ala Val  Pro Glu Thr Gly Glu  Ser Leu Ala 
    2435                 2440                 2445             


Ser Glu  Phe Leu Phe Ser Asp  Val Cys Arg Val Glu  Ser Gly Glu 
    2450                 2455                 2460             


Asn Cys  Ser Ser Pro Ala Pro  Arg Glu Glu Leu Val  Pro Ala Glu 
    2465                 2470                 2475             


Glu Thr  Glu Gln Asp Lys Glu  His Thr Cys Glu Thr  Leu Leu Met 
    2480                 2485                 2490             


Cys Ile  Val Thr Val Leu Ser  His Gly Leu Arg Ser  Gly Gly Gly 
    2495                 2500                 2505             


Val Gly  Asp Val Leu Arg Lys  Pro Ser Lys Glu Glu  Pro Leu Phe 
    2510                 2515                 2520             


Ala Ala  Arg Val Ile Tyr Asp  Leu Leu Phe Phe Phe  Met Val Ile 
    2525                 2530                 2535             


Ile Ile  Val Leu Asn Leu Ile  Phe Gly Val Ile Ile  Asp Thr Phe 
    2540                 2545                 2550             


Ala Asp  Leu Arg Ser Glu Lys  Gln Lys Lys Glu Glu  Ile Leu Lys 
    2555                 2560                 2565             


Thr Thr  Cys Phe Ile Cys Gly  Leu Glu Arg Asp Lys  Phe Asp Asn 
    2570                 2575                 2580             


Lys Thr  Val Thr Phe Glu Glu  His Ile Lys Glu Glu  His Asn Met 
    2585                 2590                 2595             


Trp His  Tyr Leu Cys Phe Ile  Val Leu Val Lys Val  Lys Asp Ser 
    2600                 2605                 2610             


Thr Glu  Tyr Thr Gly Pro Glu  Ser Tyr Val Ala Glu  Met Ile Lys 
    2615                 2620                 2625             


Glu Arg  Asn Leu Asp Trp Phe  Pro Arg Met Arg Ala  Met Ser Leu 
    2630                 2635                 2640             


Val Ser  Ser Asp Ser Glu Gly  Glu Gln Asn Glu Leu  Arg Asn Leu 
    2645                 2650                 2655             


Gln Glu  Lys Leu Glu Ser Thr  Met Lys Leu Val Thr  Asn Leu Ser 
    2660                 2665                 2670             


Gly Gln  Leu Ser Glu Leu Lys  Asp Gln Met Thr Glu  Gln Arg Lys 
    2675                 2680                 2685             


Gln Lys  Gln Arg Ile Gly Leu  Leu Gly His Pro Pro  His Met Asn 
    2690                 2695                 2700             


Val Asn  Pro Gln Gln Pro Ala  
    2705                 2710 


<210>  9031
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9031
gtggatgtgc tgctgaagcg tttcctcaag ctcgctgggg tgggaggaga ggaggaggag     60

gaggtggtgg tggaggagga ggcagggggt ggagagagag aaagcgcacg ccgagaggag    120

gtgtgggtgt tccgcttcca tcctaacgga acgagctccc tcttcgcgga catgggatta    180

cccagcggct gctaacccct ctcctcgccc tgctccccca aaccggcgtg gctccccggg    240

caccaaggag ctgactacag aggagcagga tttgcacccc tcgctgggct tgctttggca    300

acagagtgcc tgacccaggt caggattttc aagaaagaca tgtctgacaa aatgtctagc    360

ttcctacata ttggagacat ttgttctctg tacgcggagg gatcgacaaa tggatttatt    420

agcaccttgg gcctggttga tgatcgttgt gttgtacagc cagaaaccgg ggaccttaac    480

aatccaccta agaaattcag agactgcctc tttaagctat gtcccatgaa ccgctactct    540

gcccaaaagc agttctggaa agccgctaag cctggggcca acagcaccac agacgcagtg    600

ctactcaaca aactgcacca cgctgcagac ttggaaaaga agcagaatga gacagaaaac    660

aggaaattgc tggggaccgt aatccagtat ggcaatgtga tccagctcct gcatttgaaa    720

agtaataaat acctaacagt gaataagagg cttcctgctc tgttggagaa gaatgccatg    780

agagtcacat tggacgaggc tggaaatgaa gggtcctggt tttatattca gccattctac    840

aagctgcgat ccattggaga cagcgtggtc ataggtgaca aggtggttct gaaccccgtc    900

aatgctggtc agcccctaca tgctagcagc catcaactgg tagataaccc aggctgcaat    960

gaggtcaatt ccgtcaactg caatacaagc tggaaaatag tccttttcat gaaatggagt   1020

gataacaaag acgacatatt aaaggggggt gacgtggtga ggctgtttca tgctgagcag   1080

gagaagtttc tcacctgtga cgaacacagg aagaagcagc acgtcttcct gagaaccacg   1140

ggccggcagt cggccacatc tgccaccagt tcaaaagccc tgtgggaggt ggaggtggtc   1200

cagcatgacc catgtcgggg cggagcaggg tattggaaca gccttttccg tttcaagcat   1260

ctggccacgg ggcattactt ggcagcagag gtggaccctg atcaggacgc ctctcgaagt   1320

aggttgcgga atgcccaaga aaagatggta tactccctgg tctctgtgcc tgaaggcaat   1380

gacatctcct ccattttcga gctagatccc accactctgc gtggaggtga cagccttgtc   1440

ccaaggaact cttatgttcg gctcagacac ctatgtacta atacctgggt tcacagcaca   1500

aatattccta ttgacaagga agaagaaaag cccgtgatgc tgaaaattgg cacctctcct   1560

gtgaaggagg ataaggaagc atttgccata gttccggttt ctcctgctga agttcgggac   1620

ctggactttg ccaatgatgc cagcaaggtg ctgggctcca ttgctgggaa gctagagaag   1680

ggcaccatca cccagaatga aaggaggtct gtaaccaagc tgctagaaga tttggtttac   1740

ttcgtcactg gtggaactaa ttctggtcaa gatgttctcg aagttgtctt ctccaagccc   1800

aacagagaac ggcagaaact gatgagagaa cagaatattc tcaagcagat cttcaagttg   1860

ttacaagccc cattcacaga ctgcggtgat ggcccaatgc ttcggctgga agagctcggg   1920

gaccagcggc acgctccttt cagacacatc tgccggctct gctacagggt gctgagacac   1980

tcgcagcaag actacaggaa gaaccaggag tatatagcca agcagtttgg cttcatgcag   2040

aagcagattg gctatgatgt gttggctgaa gacactatca ctgccctgct ccacaataat   2100

cggaaactcc tggaaaaaca cattaccgcg gcagagattg acacatttgt cagcctggtg   2160

cgaaagaaca gggagcccag attcttagat tacctctccg acctctgtgt ctccatgaac   2220

aaatcaattc cagtgaccca ggaactgata tgtaaagctg tgctgaaccc caccaacgct   2280

gacatcctga ttgagaccaa gttggttctt tctcgttttg aatttgaagg tgtctcttcc   2340

actggagaga atgctctgga ggcaggagaa gacgaggaag aggtgtggct gttttggagg   2400

gacagcaaca aagagattcg cagcaagagt gtgagggaat tggctcagga tgctaaagaa   2460

gggcagaagg aggaccgaga cgttctcagc tactacagat atcagctgaa cctctttgcg   2520

aggatgtgtc tggaccgcca atacctggcc atcaacgaaa tctcaggcca gctggatgtc   2580

gatctcattc tccgctgcat gtctgacgag aacctgccct atgacctcag ggcgtccttc   2640

tgccgcctca tgcttcacat gcatgtggac cgagatcccc aggaacaagt cacccccgtg   2700

aaatatgccc gcctctggtc ggagattccc tcggagatcg ccattgacga ctatgatagt   2760

agtggagctt ccaaagatga aattaaggag agatttgctc agaccatgga gtttgtggag   2820

gagtatttaa gagatgtggt ttgtcagagg ttccctttct ctgataaaga gaagaataag   2880

cttacgtttg aggttgtaaa tttagctagg aatctcatat actttggttt ctacaacttc   2940

tctgaccttc tacgattaac taagatcctt ctggccatat tggactgtgt acatgtgaca   3000

acaatcttcc ccattagcaa gatggcgaaa ggagaagaga ataaaggcag taacgtgatg   3060

agatctattc atggcgtggg agagctgatg acccaggtgg tgctccgggg aggaggcttt   3120

ttgcccatga ctcccatggc tgctgcccct gaaggcaatg tgaagcaggc agagcctgag   3180

aaggaggaca tcatggtcat ggacaccaag ctgaagatca ttgagatact ccagtttatt   3240

ttgaatgtga ggttggatta taggatctcc tgcctcctgt gtatatttaa gcgagagttt   3300

gatgaaagca attcccagac ttcagaaaca tcctccggaa acagcagcca agaagggcca   3360

agtaatgtac caggtgctct tgactttgaa cacattgaag aacaagcaga aggcatcttt   3420

ggaggaagga aagagaacac cccactggac ttggatgacc acggcggcag aacctttctc   3480

cgtgtcctgc tccacttgac gatgcatgac tacccacccc tggtgtcagg ggccctgcag   3540

ctcctcttcc ggcacttcag ccagaggcag gaggtgctcc aggccttcaa acaggttcaa   3600

ctgctggtta ccagccaaga tgtggacaac tacaaacaga tcaaacaaga cttggatcaa   3660

ctgaggtcca tcgtggaaaa gtcagagctt tgggtgtaca aagggcaggg ccccgatgag   3720

actatggatg gtgcatctgg agaaaatgaa cataagaaaa cggaggaggg aaataacaag   3780

ccacaaaagc atgaaagcac cagcagctac aactacagag tggtcaaaga gattttgatt   3840

cggcttagca aactctgtgt tcaagagagt gcctcagtga gaaagagcag gaagcagcaa   3900

cagcgtctgc tccggaacat gggcgcgcac gccgtggtgc tggagctgct gcagattccc   3960

tatgagaagg ccgaagatac caagatgcaa gagataatga ggttggctca tgaatttttg   4020

cagaatttct gcgcaggcaa ccagcagaat caagctttgc tacataaaca cataaacctg   4080

tttctcaacc cagggatcct ggaggcagta accatgcagc acatcttcat gaacaatttc   4140

cagctttgca gtgagatcaa cgagagagtt gttcagcact tcgttcactg catagagact   4200

cacggtcgga atgtccagta tataaagttc ttacagacaa ttgtcaaggc agaagggaaa   4260

tttattaaaa aatgccaaga catggttatg gccgagctgg tcaattcggg agaggatgtc   4320

ctcgtgttct acaacgacag agcctctttc cagactctga tccagatgat gcggtcagaa   4380

cgggatcgga tggatgagaa cagccctctc atgtaccaca tccacttggt cgagctcctg   4440

gctgtgtgca cggagggtaa gaatgtctac acagagatca agtgcaactc cctgctcccg   4500

ctggatgaca tcgttcgcgt ggtgacccac gaggactgca tccctgaggt taaaattgca   4560

tacattaact tcctgaatca ctgctatgtg gatacagagg tggaaatgaa ggagatttat   4620

accagcaatc acatgtggaa attgtttgag aatttccttg tagacatctg cagggcctgt   4680

aacaacacta gtgacaggaa acatgcagac tcgattttgg agaagtatgt caccgaaatc   4740

gtcatgagta ttgttactac tttcttcagc tctcccttct cagaccagag tacgactttg   4800

cagactcgcc agcctgtctt tgtgcaactg ctgcaaggcg tgttcagggt ttaccactgc   4860

aactggttaa tgccaagcca aaaagcctcc gtggagagct gtattcgggt gctgtctgat   4920

gtagccaaga gccgggccat tgccattccc gtggacctgg acagccaagt caacaacctc   4980

tttctcaagt cccacagcat tgtgcagaaa acagccatga actggcggct ctcagcccgc   5040

aatgccgcac gcagggactc tgttctggca gcttccagag actaccggaa tatcattgag   5100

agattgcagg acatcgtctc cgcgctggag gaccgtctca ggcccctggt gcaggcagag   5160

ttatctgtgc tcgtggatgt tctccacaga cccgagctgc ttttcccaga gaacacagac   5220

gccagaagga aatgtgaaag tggcggtttc atttgcaagt taataaagca tacaaaacag   5280

ctgctagaag aaaatgaaga gaagctctgc attaaggtcc tacagaccct gagggaaatg   5340

atgaccaaag atagaggcta tggagaaaag ggtgaggcgc tcaggcaagt tctggtcaac   5400

cgttactatg gaaacgtcag accttcggga cgaagagaga gccttaccag ctttggcaat   5460

ggcccactgt cagcaggagg acccggcaag cccgggggag gagggggagg ttccggatcc   5520

agctctatga gcaggggtga gatgagtctg gccgaggttc agtgtcacct tgacaaggag   5580

ggggcttcca atctagttat cgacctcatc atgaacgcat ccagtgaccg agtgttccat   5640

gaaagcattc tcctggccat tgcccttctg gaaggaggca acaccaccat ccagcactcc   5700

tttttctgtc gcttgacaga agataagaag tcagagaaat tctttaaggt gttttatgac   5760

cggatgaagg tggcccagca agaaatcaaa gcaacagtga cagtgaacac cagtgacttg   5820

ggaaataaaa agaaagacga tgaggtagac agggatgccc catcacggaa aaaagctaaa   5880

gagcccacaa cacagataac agaagaggtc cgggatcagc tcctggaggc ctccgctgcc   5940

accaggaaag ccttcaccac tttcaggagg gaggctgatc ccgacgacca ctaccagcct   6000

ggagagggca cccaggccac tgccgacaag gccaaggacg acctggagat gagcgcggtc   6060

atcaccatca tgcagcccat cctccgcttc cttcagctcc tgtgtgaaaa ccacaaccga   6120

gacctgcaga acttcctccg ttgccaaaat aacaagacca actacaattt ggtatgtgag   6180

accctgcagt ttctggactg tatttgtgga agcacaactg gaggccttgg tcttctgggc   6240

ttgtatataa atgaaaagaa tgtagcgctt atcaaccaaa ccctggaaag tctgaccgaa   6300

tactgtcaag gaccttgcca tgagaaccag aactgcatag ccacccatga atccaatggc   6360

attgacatca tcacagccct gatcctcaat gatatcaatc ctttgggaaa gaagaggatg   6420

gaccttgtgt tagaactgaa gaacaatgcc tcgaagttgc tcctggccat catggaaagc   6480

aggcacgaca gtgaaaacgc agagaggata ctttataaca tgaggcccaa ggaactggtg   6540

gaagtgatca agaaagccta catgcaaggt gaagtggaat ttgaggatgg agaaaacggt   6600

gaggatgggg cggcgtcccc caggaacgtg gggcacaaca tctacatatt agcccatcag   6660

ttggctcggc ataacaaaga acttcagagc atgctgaaac ctggtggcca agtggacgga   6720

gatgaagccc tggagtttta tgccaagcac acggcgcaga tagagattgt cagattagac   6780

cgaacaatgg aacagatagt ctttcccgtg cccagcatat gtgaattcct aaccaaggag   6840

tcaaaactac gaatttacta tactacagag agagacgaac aaggcagcaa aatcaatgat   6900

ttctttctgc ggtctgaaga cctcttcaat gaaatgaatt ggcagaagaa actgagagcc   6960

cagcccgtgt tgtactggtg tgcccgcaac atgtctttct ggagcagcat ttcgtttaac   7020

ctggccgtcc tgatgaacct gctggtggcg tttttctacc cgtttaaggg agtccgagga   7080

ggaaccctgg agccccactg gtcgggactc ctgtggacag ccatgctcat ctctctggcc   7140

atcgtcattg ccctccccaa gccccatggc atccgggcct taattgcctc cacaattcta   7200

cgactgatat tttcagtcgg gttacaaccc acgttgtttc ttctgggcgc tttcaatgta   7260

tgcaataaaa tcatctttct aatgagcttt gtgggcaact gtgggacatt cacaagaggc   7320

taccgagcca tggttctgga tgttgagttc ctctatcatt tgttgtatct ggtgatctgt   7380

gccatggggc tctttgtcca tgaattcttc tacagtctgc tgctttttga tttagtgtac   7440

agagaagaga ctttgcttaa tgtcattaaa agtgtcactc gcaatggacg gtccatcatc   7500

ctgacagcag ttctggctct gatcctcgtt tacctgttct caatagtggg ctatcttttc   7560

ttcaaggatg actttatctt ggaagtagat aggctgccca atgaaacagc tgttccagaa   7620

accggcgaga gtttggcaag cgagttcctg ttctccgatg tgtgtagggt ggagagtggg   7680

gagaactgct cctctcctgc acccagagaa gagctggtcc ctgcagaaga gacggaacag   7740

gataaagagc acacatgtga gacgctgctg atgtgcattg tcactgtgct gagtcacggg   7800

ctgcggagcg ggggtggagt aggagatgta ctcaggaagc cgtccaaaga ggaacccctg   7860

tttgctgcta gagttattta tgacctcttg ttcttcttca tggtcatcat cattgttctt   7920

aacctgattt ttggggttat cattgacact tttgctgacc tgaggagtga gaagcagaag   7980

aaggaagaga tcttgaagac cacgtgcttt atctgtggct tggaaagaga caagtttgac   8040

aacaagactg tcacctttga agagcacatc aaggaagaac acaacatgtg gcactatctg   8100

tgcttcatcg tcctggtgaa agtaaaggac tccaccgaat atactgggcc tgagagttac   8160

gtggcagaaa tgatcaagga aagaaacctt ga                                 8192


<210>  9032
<211>  2695
<212>  PRT
<213>  Homosapiens

<400>  9032

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met 
                325                 330                 335     


Val Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile 
            340                 345                 350         


Phe Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro 
        355                 360                 365             


Arg Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val 
    370                 375                 380                 


His Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met 
385                 390                 395                 400 


Leu Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala 
                405                 410                 415     


Ile Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn 
            420                 425                 430         


Asp Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly 
        435                 440                 445             


Thr Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp 
    450                 455                 460                 


Leu Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu 
465                 470                 475                 480 


Glu Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg 
                485                 490                 495     


Glu Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe 
            500                 505                 510         


Thr Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp 
        515                 520                 525             


Gln Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val 
    530                 535                 540                 


Leu Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala 
545                 550                 555                 560 


Lys Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala 
                565                 570                 575     


Glu Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu 
            580                 585                 590         


Lys His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg 
        595                 600                 605             


Lys Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val 
    610                 615                 620                 


Ser Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala 
625                 630                 635                 640 


Val Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val 
                645                 650                 655     


Leu Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala 
            660                 665                 670         


Leu Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp 
        675                 680                 685             


Ser Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp 
    690                 695                 700                 


Ala Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg 
705                 710                 715                 720 


Tyr Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu 
                725                 730                 735     


Ala Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg 
            740                 745                 750         


Cys Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys 
        755                 760                 765             


Arg Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val 
    770                 775                 780                 


Thr Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile 
785                 790                 795                 800 


Ala Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys 
                805                 810                 815     


Glu Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp 
            820                 825                 830         


Val Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu 
        835                 840                 845             


Thr Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe 
    850                 855                 860                 


Tyr Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile 
865                 870                 875                 880 


Leu Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala 
                885                 890                 895     


Lys Gly Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly 
            900                 905                 910         


Val Gly Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu 
        915                 920                 925             


Pro Met Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala 
    930                 935                 940                 


Glu Pro Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile 
945                 950                 955                 960 


Ile Glu Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile 
                965                 970                 975     


Ser Cys Leu Leu Cys Ile Phe Lys Arg Glu Phe Asp Glu Ser Asn Ser 
            980                 985                 990         


Gln Thr Ser Glu Thr Ser Ser Gly  Asn Ser Ser Gln Glu  Gly Pro Ser 
        995                 1000                 1005             


Asn Val  Pro Gly Ala Leu Asp  Phe Glu His Ile Glu  Glu Gln Ala 
    1010                 1015                 1020             


Glu Gly  Ile Phe Gly Gly Arg  Lys Glu Asn Thr Pro  Leu Asp Leu 
    1025                 1030                 1035             


Asp Asp  His Gly Gly Arg Thr  Phe Leu Arg Val Leu  Leu His Leu 
    1040                 1045                 1050             


Thr Met  His Asp Tyr Pro Pro  Leu Val Ser Gly Ala  Leu Gln Leu 
    1055                 1060                 1065             


Leu Phe  Arg His Phe Ser Gln  Arg Gln Glu Val Leu  Gln Ala Phe 
    1070                 1075                 1080             


Lys Gln  Val Gln Leu Leu Val  Thr Ser Gln Asp Val  Asp Asn Tyr 
    1085                 1090                 1095             


Lys Gln  Ile Lys Gln Asp Leu  Asp Gln Leu Arg Ser  Ile Val Glu 
    1100                 1105                 1110             


Lys Ser  Glu Leu Trp Val Tyr  Lys Gly Gln Gly Pro  Asp Glu Thr 
    1115                 1120                 1125             


Met Asp  Gly Ala Ser Gly Glu  Asn Glu His Lys Lys  Thr Glu Glu 
    1130                 1135                 1140             


Gly Asn  Asn Lys Pro Gln Lys  His Glu Ser Thr Ser  Ser Tyr Asn 
    1145                 1150                 1155             


Tyr Arg  Val Val Lys Glu Ile  Leu Ile Arg Leu Ser  Lys Leu Cys 
    1160                 1165                 1170             


Val Gln  Glu Ser Ala Ser Val  Arg Lys Ser Arg Lys  Gln Gln Gln 
    1175                 1180                 1185             


Arg Leu  Leu Arg Asn Met Gly  Ala His Ala Val Val  Leu Glu Leu 
    1190                 1195                 1200             


Leu Gln  Ile Pro Tyr Glu Lys  Ala Glu Asp Thr Lys  Met Gln Glu 
    1205                 1210                 1215             


Ile Met  Arg Leu Ala His Glu  Phe Leu Gln Asn Phe  Cys Ala Gly 
    1220                 1225                 1230             


Asn Gln  Gln Asn Gln Ala Leu  Leu His Lys His Ile  Asn Leu Phe 
    1235                 1240                 1245             


Leu Asn  Pro Gly Ile Leu Glu  Ala Val Thr Met Gln  His Ile Phe 
    1250                 1255                 1260             


Met Asn  Asn Phe Gln Leu Cys  Ser Glu Ile Asn Glu  Arg Val Val 
    1265                 1270                 1275             


Gln His  Phe Val His Cys Ile  Glu Thr His Gly Arg  Asn Val Gln 
    1280                 1285                 1290             


Tyr Ile  Lys Phe Leu Gln Thr  Ile Val Lys Ala Glu  Gly Lys Phe 
    1295                 1300                 1305             


Ile Lys  Lys Cys Gln Asp Met  Val Met Ala Glu Leu  Val Asn Ser 
    1310                 1315                 1320             


Gly Glu  Asp Val Leu Val Phe  Tyr Asn Asp Arg Ala  Ser Phe Gln 
    1325                 1330                 1335             


Thr Leu  Ile Gln Met Met Arg  Ser Glu Arg Asp Arg  Met Asp Glu 
    1340                 1345                 1350             


Asn Ser  Pro Leu Met Tyr His  Ile His Leu Val Glu  Leu Leu Ala 
    1355                 1360                 1365             


Val Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1370                 1375                 1380             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Glu 
    1385                 1390                 1395             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Ile Asn  Phe Leu Asn 
    1400                 1405                 1410             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1415                 1420                 1425             


Ser Asn  His Met Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Ile 
    1430                 1435                 1440             


Cys Arg  Ala Cys Asn Asn Thr  Ser Asp Arg Lys His  Ala Asp Ser 
    1445                 1450                 1455             


Ile Leu  Glu Lys Tyr Val Thr  Glu Ile Val Met Ser  Ile Val Thr 
    1460                 1465                 1470             


Thr Phe  Phe Ser Ser Pro Phe  Ser Asp Gln Ser Thr  Thr Leu Gln 
    1475                 1480                 1485             


Thr Arg  Gln Pro Val Phe Val  Gln Leu Leu Gln Gly  Val Phe Arg 
    1490                 1495                 1500             


Val Tyr  His Cys Asn Trp Leu  Met Pro Ser Gln Lys  Ala Ser Val 
    1505                 1510                 1515             


Glu Ser  Cys Ile Arg Val Leu  Ser Asp Val Ala Lys  Ser Arg Ala 
    1520                 1525                 1530             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Asn Leu Phe 
    1535                 1540                 1545             


Leu Lys  Ser His Ser Ile Val  Gln Lys Thr Ala Met  Asn Trp Arg 
    1550                 1555                 1560             


Leu Ser  Ala Arg Asn Ala Ala  Arg Arg Asp Ser Val  Leu Ala Ala 
    1565                 1570                 1575             


Ser Arg  Asp Tyr Arg Asn Ile  Ile Glu Arg Leu Gln  Asp Ile Val 
    1580                 1585                 1590             


Ser Ala  Leu Glu Asp Arg Leu  Arg Pro Leu Val Gln  Ala Glu Leu 
    1595                 1600                 1605             


Ser Val  Leu Val Asp Val Leu  His Arg Pro Glu Leu  Leu Phe Pro 
    1610                 1615                 1620             


Glu Asn  Thr Asp Ala Arg Arg  Lys Cys Glu Ser Gly  Gly Phe Ile 
    1625                 1630                 1635             


Cys Lys  Leu Ile Lys His Thr  Lys Gln Leu Leu Glu  Glu Asn Glu 
    1640                 1645                 1650             


Glu Lys  Leu Cys Ile Lys Val  Leu Gln Thr Leu Arg  Glu Met Met 
    1655                 1660                 1665             


Thr Lys  Asp Arg Gly Tyr Gly  Glu Lys Gly Glu Ala  Leu Arg Gln 
    1670                 1675                 1680             


Val Leu  Val Asn Arg Tyr Tyr  Gly Asn Val Arg Pro  Ser Gly Arg 
    1685                 1690                 1695             


Arg Glu  Ser Leu Thr Ser Phe  Gly Asn Gly Pro Leu  Ser Ala Gly 
    1700                 1705                 1710             


Gly Pro  Gly Lys Pro Gly Gly  Gly Gly Gly Gly Ser  Gly Ser Ser 
    1715                 1720                 1725             


Ser Met  Ser Arg Gly Glu Met  Ser Leu Ala Glu Val  Gln Cys His 
    1730                 1735                 1740             


Leu Asp  Lys Glu Gly Ala Ser  Asn Leu Val Ile Asp  Leu Ile Met 
    1745                 1750                 1755             


Asn Ala  Ser Ser Asp Arg Val  Phe His Glu Ser Ile  Leu Leu Ala 
    1760                 1765                 1770             


Ile Ala  Leu Leu Glu Gly Gly  Asn Thr Thr Ile Gln  His Ser Phe 
    1775                 1780                 1785             


Phe Cys  Arg Leu Thr Glu Asp  Lys Lys Ser Glu Lys  Phe Phe Lys 
    1790                 1795                 1800             


Val Phe  Tyr Asp Arg Met Lys  Val Ala Gln Gln Glu  Ile Lys Ala 
    1805                 1810                 1815             


Thr Val  Thr Val Asn Thr Ser  Asp Leu Gly Asn Lys  Lys Lys Asp 
    1820                 1825                 1830             


Asp Glu  Val Asp Arg Asp Ala  Pro Ser Arg Lys Lys  Ala Lys Glu 
    1835                 1840                 1845             


Pro Thr  Thr Gln Ile Thr Glu  Glu Val Arg Asp Gln  Leu Leu Glu 
    1850                 1855                 1860             


Ala Ser  Ala Ala Thr Arg Lys  Ala Phe Thr Thr Phe  Arg Arg Glu 
    1865                 1870                 1875             


Ala Asp  Pro Asp Asp His Tyr  Gln Pro Gly Glu Gly  Thr Gln Ala 
    1880                 1885                 1890             


Thr Ala  Asp Lys Ala Lys Asp  Asp Leu Glu Met Ser  Ala Val Ile 
    1895                 1900                 1905             


Thr Ile  Met Gln Pro Ile Leu  Arg Phe Leu Gln Leu  Leu Cys Glu 
    1910                 1915                 1920             


Asn His  Asn Arg Asp Leu Gln  Asn Phe Leu Arg Cys  Gln Asn Asn 
    1925                 1930                 1935             


Lys Thr  Asn Tyr Asn Leu Val  Cys Glu Thr Leu Gln  Phe Leu Asp 
    1940                 1945                 1950             


Cys Ile  Cys Gly Ser Thr Thr  Gly Gly Leu Gly Leu  Leu Gly Leu 
    1955                 1960                 1965             


Tyr Ile  Asn Glu Lys Asn Val  Ala Leu Ile Asn Gln  Thr Leu Glu 
    1970                 1975                 1980             


Ser Leu  Thr Glu Tyr Cys Gln  Gly Pro Cys His Glu  Asn Gln Asn 
    1985                 1990                 1995             


Cys Ile  Ala Thr His Glu Ser  Asn Gly Ile Asp Ile  Ile Thr Ala 
    2000                 2005                 2010             


Leu Ile  Leu Asn Asp Ile Asn  Pro Leu Gly Lys Lys  Arg Met Asp 
    2015                 2020                 2025             


Leu Val  Leu Glu Leu Lys Asn  Asn Ala Ser Lys Leu  Leu Leu Ala 
    2030                 2035                 2040             


Ile Met  Glu Ser Arg His Asp  Ser Glu Asn Ala Glu  Arg Ile Leu 
    2045                 2050                 2055             


Tyr Asn  Met Arg Pro Lys Glu  Leu Val Glu Val Ile  Lys Lys Ala 
    2060                 2065                 2070             


Tyr Met  Gln Gly Glu Val Glu  Phe Glu Asp Gly Glu  Asn Gly Glu 
    2075                 2080                 2085             


Asp Gly  Ala Ala Ser Pro Arg  Asn Val Gly His Asn  Ile Tyr Ile 
    2090                 2095                 2100             


Leu Ala  His Gln Leu Ala Arg  His Asn Lys Glu Leu  Gln Ser Met 
    2105                 2110                 2115             


Leu Lys  Pro Gly Gly Gln Val  Asp Gly Asp Glu Ala  Leu Glu Phe 
    2120                 2125                 2130             


Tyr Ala  Lys His Thr Ala Gln  Ile Glu Ile Val Arg  Leu Asp Arg 
    2135                 2140                 2145             


Thr Met  Glu Gln Ile Val Phe  Pro Val Pro Ser Ile  Cys Glu Phe 
    2150                 2155                 2160             


Leu Thr  Lys Glu Ser Lys Leu  Arg Ile Tyr Tyr Thr  Thr Glu Arg 
    2165                 2170                 2175             


Asp Glu  Gln Gly Ser Lys Ile  Asn Asp Phe Phe Leu  Arg Ser Glu 
    2180                 2185                 2190             


Asp Leu  Phe Asn Glu Met Asn  Trp Gln Lys Lys Leu  Arg Ala Gln 
    2195                 2200                 2205             


Pro Val  Leu Tyr Trp Cys Ala  Arg Asn Met Ser Phe  Trp Ser Ser 
    2210                 2215                 2220             


Ile Ser  Phe Asn Leu Ala Val  Leu Met Asn Leu Leu  Val Ala Phe 
    2225                 2230                 2235             


Phe Tyr  Pro Phe Lys Gly Val  Arg Gly Gly Thr Leu  Glu Pro His 
    2240                 2245                 2250             


Trp Ser  Gly Leu Leu Trp Thr  Ala Met Leu Ile Ser  Leu Ala Ile 
    2255                 2260                 2265             


Val Ile  Ala Leu Pro Lys Pro  His Gly Ile Arg Ala  Leu Ile Ala 
    2270                 2275                 2280             


Ser Thr  Ile Leu Arg Leu Ile  Phe Ser Val Gly Leu  Gln Pro Thr 
    2285                 2290                 2295             


Leu Phe  Leu Leu Gly Ala Phe  Asn Val Cys Asn Lys  Ile Ile Phe 
    2300                 2305                 2310             


Leu Met  Ser Phe Val Gly Asn  Cys Gly Thr Phe Thr  Arg Gly Tyr 
    2315                 2320                 2325             


Arg Ala  Met Val Leu Asp Val  Glu Phe Leu Tyr His  Leu Leu Tyr 
    2330                 2335                 2340             


Leu Val  Ile Cys Ala Met Gly  Leu Phe Val His Glu  Phe Phe Tyr 
    2345                 2350                 2355             


Ser Leu  Leu Leu Phe Asp Leu  Val Tyr Arg Glu Glu  Thr Leu Leu 
    2360                 2365                 2370             


Asn Val  Ile Lys Ser Val Thr  Arg Asn Gly Arg Ser  Ile Ile Leu 
    2375                 2380                 2385             


Thr Ala  Val Leu Ala Leu Ile  Leu Val Tyr Leu Phe  Ser Ile Val 
    2390                 2395                 2400             


Gly Tyr  Leu Phe Phe Lys Asp  Asp Phe Ile Leu Glu  Val Asp Arg 
    2405                 2410                 2415             


Leu Pro  Asn Glu Thr Ala Val  Pro Glu Thr Gly Glu  Ser Leu Ala 
    2420                 2425                 2430             


Ser Glu  Phe Leu Phe Ser Asp  Val Cys Arg Val Glu  Ser Gly Glu 
    2435                 2440                 2445             


Asn Cys  Ser Ser Pro Ala Pro  Arg Glu Glu Leu Val  Pro Ala Glu 
    2450                 2455                 2460             


Glu Thr  Glu Gln Asp Lys Glu  His Thr Cys Glu Thr  Leu Leu Met 
    2465                 2470                 2475             


Cys Ile  Val Thr Val Leu Ser  His Gly Leu Arg Ser  Gly Gly Gly 
    2480                 2485                 2490             


Val Gly  Asp Val Leu Arg Lys  Pro Ser Lys Glu Glu  Pro Leu Phe 
    2495                 2500                 2505             


Ala Ala  Arg Val Ile Tyr Asp  Leu Leu Phe Phe Phe  Met Val Ile 
    2510                 2515                 2520             


Ile Ile  Val Leu Asn Leu Ile  Phe Gly Val Ile Ile  Asp Thr Phe 
    2525                 2530                 2535             


Ala Asp  Leu Arg Ser Glu Lys  Gln Lys Lys Glu Glu  Ile Leu Lys 
    2540                 2545                 2550             


Thr Thr  Cys Phe Ile Cys Gly  Leu Glu Arg Asp Lys  Phe Asp Asn 
    2555                 2560                 2565             


Lys Thr  Val Thr Phe Glu Glu  His Ile Lys Glu Glu  His Asn Met 
    2570                 2575                 2580             


Trp His  Tyr Leu Cys Phe Ile  Val Leu Val Lys Val  Lys Asp Ser 
    2585                 2590                 2595             


Thr Glu  Tyr Thr Gly Pro Glu  Ser Tyr Val Ala Glu  Met Ile Lys 
    2600                 2605                 2610             


Glu Arg  Asn Leu Asp Trp Phe  Pro Arg Met Arg Ala  Met Ser Leu 
    2615                 2620                 2625             


Val Ser  Ser Asp Ser Glu Gly  Glu Gln Asn Glu Leu  Arg Asn Leu 
    2630                 2635                 2640             


Gln Glu  Lys Leu Glu Ser Thr  Met Lys Leu Val Thr  Asn Leu Ser 
    2645                 2650                 2655             


Gly Gln  Leu Ser Glu Leu Lys  Asp Gln Met Thr Glu  Gln Arg Lys 
    2660                 2665                 2670             


Gln Lys  Gln Arg Ile Gly Leu  Leu Gly His Pro Pro  His Met Asn 
    2675                 2680                 2685             


Val Asn  Pro Gln Gln Pro Ala  
    2690                 2695 


<210>  9033
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9033
gtggatgtgc tgctgaagcg tttcctcaag ctcgctgggg tgggaggaga ggaggaggag     60

gaggtggtgg tggaggagga ggcagggggt ggagagagag aaagcgcacg ccgagaggag    120

gtgtgggtgt tccgcttcca tcctaacgga acgagctccc tcttcgcgga catgggatta    180

cccagcggct gctaacccct ctcctcgccc tgctccccca aaccggcgtg gctccccggg    240

caccaaggag ctgactacag aggagcagga tttgcacccc tcgctgggct tgctttggca    300

acagagtgcc tgacccaggt caggattttc aagaaagaca tgtctgacaa aatgtctagc    360

ttcctacata ttggagacat ttgttctctg tacgcggagg gatcgacaaa tggatttatt    420

agcaccttgg gcctggttga tgatcgttgt gttgtacagc cagaaaccgg ggaccttaac    480

aatccaccta agaaattcag agactgcctc tttaagctat gtcccatgaa ccgctactct    540

gcccaaaagc agttctggaa agccgctaag cctggggcca acagcaccac agacgcagtg    600

ctactcaaca aactgcacca cgctgcagac ttggaaaaga agcagaatga gacagaaaac    660

aggaaattgc tggggaccgt aatccagtat ggcaatgtga tccagctcct gcatttgaaa    720

agtaataaat acctaacagt gaataagagg cttcctgctc tgttggagaa gaatgccatg    780

agagtcacat tggacgaggc tggaaatgaa gggtcctggt tttatattca gccattctac    840

aagctgcgat ccattggaga cagcgtggtc ataggtgaca aggtggttct gaaccccgtc    900

aatgctggtc agcccctaca tgctagcagc catcaactgg tagataaccc aggctgcaat    960

gaggtcaatt ccgtcaactg caatacaagc tggaaaatag tccttttcat gaaatggagt   1020

gataacaaag acgacatatt aaaggggggt gacgtggtga ggctgtttca tgctgagcag   1080

gagaagtttc tcacctgtga cgaacacagg aagaagcagc acgtcttcct gagaaccacg   1140

ggccggcagt cggccacatc tgccaccagt tcaaaagccc tgtgggaggt ggaggtggtc   1200

cagcatgacc catgtcgggg cggagcaggg tattggaaca gccttttccg tttcaagcat   1260

ctggccacgg ggcattactt ggcagcagag gtagaccctg actttgagga agaatgcctg   1320

gagtttcagc cctcagtgga ccctgatcag gacgcctctc gaagtaggtt gcggaatgcc   1380

caagaaaaga tggtatactc cctggtctct gtgcctgaag gcaatgacat ctcctccatt   1440

ttcgagctag atcccaccac tctgcgtgga ggtgacagcc ttgtcccaag gaactcttat   1500

gttcggctca gacacctatg tactaatacc tgggttcaca gcacaaatat tcctattgac   1560

aaggaagaag aaaagcccgt gatgctgaaa attggcacct ctcctgtgaa ggaggataag   1620

gaagcatttg ccatagttcc ggtttctcct gctgaagttc gggacctgga ctttgccaat   1680

gatgccagca aggtgctggg ctccattgct gggaagctag agaagggcac catcacccag   1740

aatgaaagga ggtctgtaac caagctgcta gaagatttgg tttacttcgt cactggtgga   1800

actaattctg gtcaagatgt tctcgaagtt gtcttctcca agcccaacag agaacggcag   1860

aaactgatga gagaacagaa tattctcaag cagatcttca agttgttaca agccccattc   1920

acagactgcg gtgatggccc aatgcttcgg ctggaagagc tcggggacca gcggcacgct   1980

cctttcagac acatctgccg gctctgctac agggtgctga gacactcgca gcaagactac   2040

aggaagaacc aggagtatat agccaagcag tttggcttca tgcagaagca gattggctat   2100

gatgtgttgg ctgaagacac tatcactgcc ctgctccaca ataatcggaa actcctggaa   2160

aaacacatta ccgcggcaga gattgacaca tttgtcagcc tggtgcgaaa gaacagggag   2220

cccagattct tagattacct ctccgacctc tgtgtctcca tgaacaaatc aattccagtg   2280

acccaggaac tgatatgtaa agctgtgctg aaccccacca acgctgacat cctgattgag   2340

accaagttgg ttctttctcg ttttgaattt gaaggtgtct cttccactgg agagaatgct   2400

ctggaggcag gagaagacga ggaagaggtg tggctgtttt ggagggacag caacaaagag   2460

attcgcagca agagtgtgag ggaattggct caggatgcta aagaagggca gaaggaggac   2520

cgagacgttc tcagctacta cagatatcag ctgaacctct ttgcgaggat gtgtctggac   2580

cgccaatacc tggccatcaa cgaaatctca ggccagctgg atgtcgatct cattctccgc   2640

tgcatgtctg acgagaacct gccctatgac ctcagggcgt ccttctgccg cctcatgctt   2700

cacatgcatg tggaccgaga tccccaggaa caagtcaccc ccgtgaaata tgcccgcctc   2760

tggtcggaga ttccctcgga gatcgccatt gacgactatg atagtagtgg agcttccaaa   2820

gatgaaatta aggagagatt tgctcagacc atggagtttg tggaggagta tttaagagat   2880

gtggtttgtc agaggttccc tttctctgat aaagagaaga ataagcttac gtttgaggtt   2940

gtaaatttag ctaggaatct catatacttt ggtttctaca acttctctga ccttctacga   3000

ttaactaaga tccttctggc catattggac tgtgtacatg tgacaacaat cttccccatt   3060

agcaagatgg cgaaaggaga agagaataaa ggcagtaacg tgatgagatc tattcatggc   3120

gtgggagagc tgatgaccca ggtggtgctc cggggaggag gctttttgcc catgactccc   3180

atggctgctg cccctgaagg caatgtgaag caggcagagc ctgagaagga ggacatcatg   3240

gtcatggaca ccaagctgaa gatcattgag atactccagt ttattttgaa tgtgaggttg   3300

gattatagga tctcctgcct cctgtgtata tttaagcgag agtttgatga aagcaattcc   3360

cagacttcag aaacatcctc cggaaacagc agccaagaag ggccaagtaa tgtaccaggt   3420

gctcttgact ttgaacacat tgaagaacaa gcagaaggca tctttggagg aaggaaagag   3480

aacaccccac tggacttgga tgaccacggc ggcagaacct ttctccgtgt cctgctccac   3540

ttgacgatgc atgactaccc acccctggtg tcaggggccc tgcagctcct cttccggcac   3600

ttcagccaga ggcaggaggt gctccaggcc ttcaaacagg ttcaactgct ggttaccagc   3660

caagatgtgg acaactacaa acagatcaaa caagacttgg atcaactgag gtccatcgtg   3720

gaaaagtcag agctttgggt gtacaaaggg cagggccccg atgagactat ggatggtgca   3780

tctggagaaa atgaacataa gaaaacggag gagggaaata acaagccaca aaagcatgaa   3840

agcaccagca gctacaacta cagagtggtc aaagagattt tgattcggct tagcaaactc   3900

tgtgttcaag agagtgcctc agtgagaaag agcaggaagc agcaacagcg tctgctccgg   3960

aacatgggcg cgcacgccgt ggtgctggag ctgctgcaga ttccctatga gaaggccgaa   4020

gataccaaga tgcaagagat aatgaggttg gctcatgaat ttttgcagaa tttctgcgca   4080

ggcaaccagc agaatcaagc tttgctacat aaacacataa acctgtttct caacccaggg   4140

atcctggagg cagtaaccat gcagcacatc ttcatgaaca atttccagct ttgcagtgag   4200

atcaacgaga gagttgttca gcacttcgtt cactgcatag agactcacgg tcggaatgtc   4260

cagtatataa agttcttaca gacaattgtc aaggcagaag ggaaatttat taaaaaatgc   4320

caagacatgg ttatggccga gctggtcaat tcgggagagg atgtcctcgt gttctacaac   4380

gacagagcct ctttccagac tctgatccag atgatgcggt cagaacggga tcggatggat   4440

gagaacagcc ctctcatgta ccacatccac ttggtcgagc tcctggctgt gtgcacggag   4500

ggtaagaatg tctacacaga gatcaagtgc aactccctgc tcccgctgga tgacatcgtt   4560

cgcgtggtga cccacgagga ctgcatccct gaggttaaaa ttgcatacat taacttcctg   4620

aatcactgct atgtggatac agaggtggaa atgaaggaga tttataccag caatcacatg   4680

tggaaattgt ttgagaattt ccttgtagac atctgcaggg cctgtaacaa cactagtgac   4740

aggaaacatg cagactcgat tttggagaag tatgtcaccg aaatcgtcat gagtattgtt   4800

actactttct tcagctctcc cttctcagac cagagtacga ctttgcagac tcgccagcct   4860

gtctttgtgc aactgctgca aggcgtgttc agggtttacc actgcaactg gttaatgcca   4920

agccaaaaag cctccgtgga gagctgtatt cgggtgctgt ctgatgtagc caagagccgg   4980

gccattgcca ttcccgtgga cctggacagc caagtcaaca acctctttct caagtcccac   5040

agcattgtgc agaaaacagc catgaactgg cggctctcag cccgcaatgc cgcacgcagg   5100

gactctgttc tggcagcttc cagagactac cggaatatca ttgagagatt gcaggacatc   5160

gtctccgcgc tggaggaccg tctcaggccc ctggtgcagg cagagttatc tgtgctcgtg   5220

gatgttctcc acagacccga gctgcttttc ccagagaaca cagacgccag aaggaaatgt   5280

gaaagtggcg gtttcatttg caagttaata aagcatacaa aacagctgct agaagaaaat   5340

gaagagaagc tctgcattaa ggtcctacag accctgaggg aaatgatgac caaagataga   5400

ggctatggag aaaagggtga ggcgctcagg caagttctgg tcaaccgtta ctatggaaac   5460

gtcagacctt cgggacgaag agagagcctt accagctttg gcaatggccc actgtcagca   5520

ggaggacccg gcaagcccgg gggaggaggg ggaggttccg gatccagctc tatgagcagg   5580

ggtgagatga gtctggccga ggttcagtgt caccttgaca aggagggggc ttccaatcta   5640

gttatcgacc tcatcatgaa cgcatccagt gaccgagtgt tccatgaaag cattctcctg   5700

gccattgccc ttctggaagg aggcaacacc accatccagc actccttttt ctgtcgcttg   5760

acagaagata agaagtcaga gaaattcttt aaggtgtttt atgaccggat gaaggtggcc   5820

cagcaagaaa tcaaagcaac agtgacagtg aacaccagtg acttgggaaa taaaaagaaa   5880

gacgatgagg tagacaggga tgccccatca cggaaaaaag ctaaagagcc cacaacacag   5940

ataacagaag aggtccggga tcagctcctg gaggcctccg ctgccaccag gaaagccttc   6000

accactttca ggagggaggc tgatcccgac gaccactacc agcctggaga gggcacccag   6060

gccactgccg acaaggccaa ggacgacctg gagatgagcg cggtcatcac catcatgcag   6120

cccatcctcc gcttccttca gctcctgtgt gaaaaccaca accgagacct gcagaacttc   6180

ctccgttgcc aaaataacaa gaccaactac aatttggtat gtgagaccct gcagtttctg   6240

gactgtattt gtggaagcac aactggaggc cttggtcttc tgggcttgta tataaatgaa   6300

aagaatgtag cgcttatcaa ccaaaccctg gaaagtctga ccgaatactg tcaaggacct   6360

tgccatgaga accagaactg catagccacc catgaatcca atggcattga catcatcaca   6420

gccctgatcc tcaatgatat caatcctttg ggaaagaaga ggatggacct tgtgttagaa   6480

ctgaagaaca atgcctcgaa gttgctcctg gccatcatgg aaagcaggca cgacagtgaa   6540

aacgcagaga ggatacttta taacatgagg cccaaggaac tggtggaagt gatcaagaaa   6600

gcctacatgc aaggtgaagt ggaatttgag gatggagaaa acggtgagga tggggcggcg   6660

tcccccagga acgtggggca caacatctac atattagccc atcagttggc tcggcataac   6720

aaagaacttc agagcatgct gaaacctggt ggccaagtgg acggagatga agccctggag   6780

ttttatgcca agcacacggc gcagatagag attgtcagat tagaccgaac aatggaacag   6840

atagtctttc ccgtgcccag catatgtgaa ttcctaacca aggagtcaaa actacgaatt   6900

tactatacta cagagagaga cgaacaaggc agcaaaatca atgatttctt tctgcggtct   6960

gaagacctct tcaatgaaat gaattggcag aagaaactga gagcccagcc cgtgttgtac   7020

tggtgtgccc gcaacatgtc tttctggagc agcatttcgt ttaacctggc cgtcctgatg   7080

aacctgctgg tggcgttttt ctacccgttt aagggagtcc gaggaggaac cctggagccc   7140

cactggtcgg gactcctgtg gacagccatg ctcatctctc tggccatcgt cattgccctc   7200

cccaagcccc atggcatccg ggccttaatt gcctccacaa ttctacgact gatattttca   7260

gtcgggttac aacccacgtt gtttcttctg ggcgctttca atgtatgcaa taaaatcatc   7320

tttctaatga gctttgtggg caactgtggg acattcacaa gaggctaccg agccatggtt   7380

ctggatgttg agttcctcta tcatttgttg tatctggtga tctgtgccat ggggctcttt   7440

gtccatgaat tcttctacag tctgctgctt tttgatttag tgtacagaga agagactttg   7500

cttaatgtca ttaaaagtgt cactcgcaat ggacggtcca tcatcctgac agcagttctg   7560

gctctgatcc tcgtttacct gttctcaata gtgggctatc ttttcttcaa ggatgacttt   7620

atcttggaag tagataggct gcccaatgaa acagctgttc cagaaaccgg cgagagtttg   7680

gcaagcgagt tcctgttctc cgatgtgtgt agggtggaga gtggggagaa ctgctcctct   7740

cctgcaccca gagaagagct ggtccctgca gaagagacgg aacaggataa agagcacaca   7800

tgtgagacgc tgctgatgtg cattgtcact gtgctgagtc acgggctgcg gagcgggggt   7860

ggagtaggag atgtactcag gaagccgtcc aaagaggaac ccctgtttgc tgctagagtt   7920

atttatgacc tcttgttctt cttcatggtc atcatcattg ttcttaacct gatttttggg   7980

gttatcattg acacttttgc tgacctgagg agtgagaagc agaagaagga agagatcttg   8040

aagaccacgt gctttatctg tggcttggaa agagacaagt ttgacaacaa gactgtcacc   8100

tttgaagagc acatcaagga agaacacaac atgtggcact atctgtgctt catcgtcctg   8160

gtgaaagtaa aggactccac cgaatatact gg                                 8192


<210>  9034
<211>  2710
<212>  PRT
<213>  Homosapiens

<400>  9034

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Phe Glu Glu Glu Cys Leu Glu Phe Gln Pro Ser Val Asp Pro Asp 
                325                 330                 335     


Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met Val 
            340                 345                 350         


Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile Phe 
        355                 360                 365             


Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro Arg 
    370                 375                 380                 


Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val His 
385                 390                 395                 400 


Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met Leu 
                405                 410                 415     


Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala Ile 
            420                 425                 430         


Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn Asp 
        435                 440                 445             


Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly Thr 
    450                 455                 460                 


Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp Leu 
465                 470                 475                 480 


Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu Glu 
                485                 490                 495     


Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu 
            500                 505                 510         


Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe Thr 
        515                 520                 525             


Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp Gln 
    530                 535                 540                 


Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys 
                565                 570                 575     


Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg Lys 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala Val 
                645                 650                 655     


Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val Leu 
            660                 665                 670         


Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala Leu 
        675                 680                 685             


Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp Ser 
    690                 695                 700                 


Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp Ala 
705                 710                 715                 720 


Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg Tyr 
                725                 730                 735     


Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala 
            740                 745                 750         


Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg Cys 
        755                 760                 765             


Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys Arg 
    770                 775                 780                 


Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val Thr 
785                 790                 795                 800 


Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile Ala 
                805                 810                 815     


Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys Glu 
            820                 825                 830         


Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp Val 
        835                 840                 845             


Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu Thr 
    850                 855                 860                 


Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr 
865                 870                 875                 880 


Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile Leu 
                885                 890                 895     


Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala Lys 
            900                 905                 910         


Gly Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly Val 
        915                 920                 925             


Gly Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu Pro 
    930                 935                 940                 


Met Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala Glu 
945                 950                 955                 960 


Pro Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile Ile 
                965                 970                 975     


Glu Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser 
            980                 985                 990         


Cys Leu Leu Cys Ile Phe Lys Arg  Glu Phe Asp Glu Ser  Asn Ser Gln 
        995                 1000                 1005             


Thr Ser  Glu Thr Ser Ser Gly  Asn Ser Ser Gln Glu  Gly Pro Ser 
    1010                 1015                 1020             


Asn Val  Pro Gly Ala Leu Asp  Phe Glu His Ile Glu  Glu Gln Ala 
    1025                 1030                 1035             


Glu Gly  Ile Phe Gly Gly Arg  Lys Glu Asn Thr Pro  Leu Asp Leu 
    1040                 1045                 1050             


Asp Asp  His Gly Gly Arg Thr  Phe Leu Arg Val Leu  Leu His Leu 
    1055                 1060                 1065             


Thr Met  His Asp Tyr Pro Pro  Leu Val Ser Gly Ala  Leu Gln Leu 
    1070                 1075                 1080             


Leu Phe  Arg His Phe Ser Gln  Arg Gln Glu Val Leu  Gln Ala Phe 
    1085                 1090                 1095             


Lys Gln  Val Gln Leu Leu Val  Thr Ser Gln Asp Val  Asp Asn Tyr 
    1100                 1105                 1110             


Lys Gln  Ile Lys Gln Asp Leu  Asp Gln Leu Arg Ser  Ile Val Glu 
    1115                 1120                 1125             


Lys Ser  Glu Leu Trp Val Tyr  Lys Gly Gln Gly Pro  Asp Glu Thr 
    1130                 1135                 1140             


Met Asp  Gly Ala Ser Gly Glu  Asn Glu His Lys Lys  Thr Glu Glu 
    1145                 1150                 1155             


Gly Asn  Asn Lys Pro Gln Lys  His Glu Ser Thr Ser  Ser Tyr Asn 
    1160                 1165                 1170             


Tyr Arg  Val Val Lys Glu Ile  Leu Ile Arg Leu Ser  Lys Leu Cys 
    1175                 1180                 1185             


Val Gln  Glu Ser Ala Ser Val  Arg Lys Ser Arg Lys  Gln Gln Gln 
    1190                 1195                 1200             


Arg Leu  Leu Arg Asn Met Gly  Ala His Ala Val Val  Leu Glu Leu 
    1205                 1210                 1215             


Leu Gln  Ile Pro Tyr Glu Lys  Ala Glu Asp Thr Lys  Met Gln Glu 
    1220                 1225                 1230             


Ile Met  Arg Leu Ala His Glu  Phe Leu Gln Asn Phe  Cys Ala Gly 
    1235                 1240                 1245             


Asn Gln  Gln Asn Gln Ala Leu  Leu His Lys His Ile  Asn Leu Phe 
    1250                 1255                 1260             


Leu Asn  Pro Gly Ile Leu Glu  Ala Val Thr Met Gln  His Ile Phe 
    1265                 1270                 1275             


Met Asn  Asn Phe Gln Leu Cys  Ser Glu Ile Asn Glu  Arg Val Val 
    1280                 1285                 1290             


Gln His  Phe Val His Cys Ile  Glu Thr His Gly Arg  Asn Val Gln 
    1295                 1300                 1305             


Tyr Ile  Lys Phe Leu Gln Thr  Ile Val Lys Ala Glu  Gly Lys Phe 
    1310                 1315                 1320             


Ile Lys  Lys Cys Gln Asp Met  Val Met Ala Glu Leu  Val Asn Ser 
    1325                 1330                 1335             


Gly Glu  Asp Val Leu Val Phe  Tyr Asn Asp Arg Ala  Ser Phe Gln 
    1340                 1345                 1350             


Thr Leu  Ile Gln Met Met Arg  Ser Glu Arg Asp Arg  Met Asp Glu 
    1355                 1360                 1365             


Asn Ser  Pro Leu Met Tyr His  Ile His Leu Val Glu  Leu Leu Ala 
    1370                 1375                 1380             


Val Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1385                 1390                 1395             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Glu 
    1400                 1405                 1410             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Ile Asn  Phe Leu Asn 
    1415                 1420                 1425             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1430                 1435                 1440             


Ser Asn  His Met Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Ile 
    1445                 1450                 1455             


Cys Arg  Ala Cys Asn Asn Thr  Ser Asp Arg Lys His  Ala Asp Ser 
    1460                 1465                 1470             


Ile Leu  Glu Lys Tyr Val Thr  Glu Ile Val Met Ser  Ile Val Thr 
    1475                 1480                 1485             


Thr Phe  Phe Ser Ser Pro Phe  Ser Asp Gln Ser Thr  Thr Leu Gln 
    1490                 1495                 1500             


Thr Arg  Gln Pro Val Phe Val  Gln Leu Leu Gln Gly  Val Phe Arg 
    1505                 1510                 1515             


Val Tyr  His Cys Asn Trp Leu  Met Pro Ser Gln Lys  Ala Ser Val 
    1520                 1525                 1530             


Glu Ser  Cys Ile Arg Val Leu  Ser Asp Val Ala Lys  Ser Arg Ala 
    1535                 1540                 1545             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Asn Leu Phe 
    1550                 1555                 1560             


Leu Lys  Ser His Ser Ile Val  Gln Lys Thr Ala Met  Asn Trp Arg 
    1565                 1570                 1575             


Leu Ser  Ala Arg Asn Ala Ala  Arg Arg Asp Ser Val  Leu Ala Ala 
    1580                 1585                 1590             


Ser Arg  Asp Tyr Arg Asn Ile  Ile Glu Arg Leu Gln  Asp Ile Val 
    1595                 1600                 1605             


Ser Ala  Leu Glu Asp Arg Leu  Arg Pro Leu Val Gln  Ala Glu Leu 
    1610                 1615                 1620             


Ser Val  Leu Val Asp Val Leu  His Arg Pro Glu Leu  Leu Phe Pro 
    1625                 1630                 1635             


Glu Asn  Thr Asp Ala Arg Arg  Lys Cys Glu Ser Gly  Gly Phe Ile 
    1640                 1645                 1650             


Cys Lys  Leu Ile Lys His Thr  Lys Gln Leu Leu Glu  Glu Asn Glu 
    1655                 1660                 1665             


Glu Lys  Leu Cys Ile Lys Val  Leu Gln Thr Leu Arg  Glu Met Met 
    1670                 1675                 1680             


Thr Lys  Asp Arg Gly Tyr Gly  Glu Lys Gly Glu Ala  Leu Arg Gln 
    1685                 1690                 1695             


Val Leu  Val Asn Arg Tyr Tyr  Gly Asn Val Arg Pro  Ser Gly Arg 
    1700                 1705                 1710             


Arg Glu  Ser Leu Thr Ser Phe  Gly Asn Gly Pro Leu  Ser Ala Gly 
    1715                 1720                 1725             


Gly Pro  Gly Lys Pro Gly Gly  Gly Gly Gly Gly Ser  Gly Ser Ser 
    1730                 1735                 1740             


Ser Met  Ser Arg Gly Glu Met  Ser Leu Ala Glu Val  Gln Cys His 
    1745                 1750                 1755             


Leu Asp  Lys Glu Gly Ala Ser  Asn Leu Val Ile Asp  Leu Ile Met 
    1760                 1765                 1770             


Asn Ala  Ser Ser Asp Arg Val  Phe His Glu Ser Ile  Leu Leu Ala 
    1775                 1780                 1785             


Ile Ala  Leu Leu Glu Gly Gly  Asn Thr Thr Ile Gln  His Ser Phe 
    1790                 1795                 1800             


Phe Cys  Arg Leu Thr Glu Asp  Lys Lys Ser Glu Lys  Phe Phe Lys 
    1805                 1810                 1815             


Val Phe  Tyr Asp Arg Met Lys  Val Ala Gln Gln Glu  Ile Lys Ala 
    1820                 1825                 1830             


Thr Val  Thr Val Asn Thr Ser  Asp Leu Gly Asn Lys  Lys Lys Asp 
    1835                 1840                 1845             


Asp Glu  Val Asp Arg Asp Ala  Pro Ser Arg Lys Lys  Ala Lys Glu 
    1850                 1855                 1860             


Pro Thr  Thr Gln Ile Thr Glu  Glu Val Arg Asp Gln  Leu Leu Glu 
    1865                 1870                 1875             


Ala Ser  Ala Ala Thr Arg Lys  Ala Phe Thr Thr Phe  Arg Arg Glu 
    1880                 1885                 1890             


Ala Asp  Pro Asp Asp His Tyr  Gln Pro Gly Glu Gly  Thr Gln Ala 
    1895                 1900                 1905             


Thr Ala  Asp Lys Ala Lys Asp  Asp Leu Glu Met Ser  Ala Val Ile 
    1910                 1915                 1920             


Thr Ile  Met Gln Pro Ile Leu  Arg Phe Leu Gln Leu  Leu Cys Glu 
    1925                 1930                 1935             


Asn His  Asn Arg Asp Leu Gln  Asn Phe Leu Arg Cys  Gln Asn Asn 
    1940                 1945                 1950             


Lys Thr  Asn Tyr Asn Leu Val  Cys Glu Thr Leu Gln  Phe Leu Asp 
    1955                 1960                 1965             


Cys Ile  Cys Gly Ser Thr Thr  Gly Gly Leu Gly Leu  Leu Gly Leu 
    1970                 1975                 1980             


Tyr Ile  Asn Glu Lys Asn Val  Ala Leu Ile Asn Gln  Thr Leu Glu 
    1985                 1990                 1995             


Ser Leu  Thr Glu Tyr Cys Gln  Gly Pro Cys His Glu  Asn Gln Asn 
    2000                 2005                 2010             


Cys Ile  Ala Thr His Glu Ser  Asn Gly Ile Asp Ile  Ile Thr Ala 
    2015                 2020                 2025             


Leu Ile  Leu Asn Asp Ile Asn  Pro Leu Gly Lys Lys  Arg Met Asp 
    2030                 2035                 2040             


Leu Val  Leu Glu Leu Lys Asn  Asn Ala Ser Lys Leu  Leu Leu Ala 
    2045                 2050                 2055             


Ile Met  Glu Ser Arg His Asp  Ser Glu Asn Ala Glu  Arg Ile Leu 
    2060                 2065                 2070             


Tyr Asn  Met Arg Pro Lys Glu  Leu Val Glu Val Ile  Lys Lys Ala 
    2075                 2080                 2085             


Tyr Met  Gln Gly Glu Val Glu  Phe Glu Asp Gly Glu  Asn Gly Glu 
    2090                 2095                 2100             


Asp Gly  Ala Ala Ser Pro Arg  Asn Val Gly His Asn  Ile Tyr Ile 
    2105                 2110                 2115             


Leu Ala  His Gln Leu Ala Arg  His Asn Lys Glu Leu  Gln Ser Met 
    2120                 2125                 2130             


Leu Lys  Pro Gly Gly Gln Val  Asp Gly Asp Glu Ala  Leu Glu Phe 
    2135                 2140                 2145             


Tyr Ala  Lys His Thr Ala Gln  Ile Glu Ile Val Arg  Leu Asp Arg 
    2150                 2155                 2160             


Thr Met  Glu Gln Ile Val Phe  Pro Val Pro Ser Ile  Cys Glu Phe 
    2165                 2170                 2175             


Leu Thr  Lys Glu Ser Lys Leu  Arg Ile Tyr Tyr Thr  Thr Glu Arg 
    2180                 2185                 2190             


Asp Glu  Gln Gly Ser Lys Ile  Asn Asp Phe Phe Leu  Arg Ser Glu 
    2195                 2200                 2205             


Asp Leu  Phe Asn Glu Met Asn  Trp Gln Lys Lys Leu  Arg Ala Gln 
    2210                 2215                 2220             


Pro Val  Leu Tyr Trp Cys Ala  Arg Asn Met Ser Phe  Trp Ser Ser 
    2225                 2230                 2235             


Ile Ser  Phe Asn Leu Ala Val  Leu Met Asn Leu Leu  Val Ala Phe 
    2240                 2245                 2250             


Phe Tyr  Pro Phe Lys Gly Val  Arg Gly Gly Thr Leu  Glu Pro His 
    2255                 2260                 2265             


Trp Ser  Gly Leu Leu Trp Thr  Ala Met Leu Ile Ser  Leu Ala Ile 
    2270                 2275                 2280             


Val Ile  Ala Leu Pro Lys Pro  His Gly Ile Arg Ala  Leu Ile Ala 
    2285                 2290                 2295             


Ser Thr  Ile Leu Arg Leu Ile  Phe Ser Val Gly Leu  Gln Pro Thr 
    2300                 2305                 2310             


Leu Phe  Leu Leu Gly Ala Phe  Asn Val Cys Asn Lys  Ile Ile Phe 
    2315                 2320                 2325             


Leu Met  Ser Phe Val Gly Asn  Cys Gly Thr Phe Thr  Arg Gly Tyr 
    2330                 2335                 2340             


Arg Ala  Met Val Leu Asp Val  Glu Phe Leu Tyr His  Leu Leu Tyr 
    2345                 2350                 2355             


Leu Val  Ile Cys Ala Met Gly  Leu Phe Val His Glu  Phe Phe Tyr 
    2360                 2365                 2370             


Ser Leu  Leu Leu Phe Asp Leu  Val Tyr Arg Glu Glu  Thr Leu Leu 
    2375                 2380                 2385             


Asn Val  Ile Lys Ser Val Thr  Arg Asn Gly Arg Ser  Ile Ile Leu 
    2390                 2395                 2400             


Thr Ala  Val Leu Ala Leu Ile  Leu Val Tyr Leu Phe  Ser Ile Val 
    2405                 2410                 2415             


Gly Tyr  Leu Phe Phe Lys Asp  Asp Phe Ile Leu Glu  Val Asp Arg 
    2420                 2425                 2430             


Leu Pro  Asn Glu Thr Ala Val  Pro Glu Thr Gly Glu  Ser Leu Ala 
    2435                 2440                 2445             


Ser Glu  Phe Leu Phe Ser Asp  Val Cys Arg Val Glu  Ser Gly Glu 
    2450                 2455                 2460             


Asn Cys  Ser Ser Pro Ala Pro  Arg Glu Glu Leu Val  Pro Ala Glu 
    2465                 2470                 2475             


Glu Thr  Glu Gln Asp Lys Glu  His Thr Cys Glu Thr  Leu Leu Met 
    2480                 2485                 2490             


Cys Ile  Val Thr Val Leu Ser  His Gly Leu Arg Ser  Gly Gly Gly 
    2495                 2500                 2505             


Val Gly  Asp Val Leu Arg Lys  Pro Ser Lys Glu Glu  Pro Leu Phe 
    2510                 2515                 2520             


Ala Ala  Arg Val Ile Tyr Asp  Leu Leu Phe Phe Phe  Met Val Ile 
    2525                 2530                 2535             


Ile Ile  Val Leu Asn Leu Ile  Phe Gly Val Ile Ile  Asp Thr Phe 
    2540                 2545                 2550             


Ala Asp  Leu Arg Ser Glu Lys  Gln Lys Lys Glu Glu  Ile Leu Lys 
    2555                 2560                 2565             


Thr Thr  Cys Phe Ile Cys Gly  Leu Glu Arg Asp Lys  Phe Asp Asn 
    2570                 2575                 2580             


Lys Thr  Val Thr Phe Glu Glu  His Ile Lys Glu Glu  His Asn Met 
    2585                 2590                 2595             


Trp His  Tyr Leu Cys Phe Ile  Val Leu Val Lys Val  Lys Asp Ser 
    2600                 2605                 2610             


Thr Glu  Tyr Thr Gly Pro Glu  Ser Tyr Val Ala Glu  Met Ile Lys 
    2615                 2620                 2625             


Glu Arg  Asn Leu Asp Trp Phe  Pro Arg Met Arg Ala  Met Ser Leu 
    2630                 2635                 2640             


Val Ser  Ser Asp Ser Glu Gly  Glu Gln Asn Glu Leu  Arg Asn Leu 
    2645                 2650                 2655             


Gln Glu  Lys Leu Glu Ser Thr  Met Lys Leu Val Thr  Asn Leu Ser 
    2660                 2665                 2670             


Gly Gln  Leu Ser Glu Leu Lys  Asp Gln Met Thr Glu  Gln Arg Lys 
    2675                 2680                 2685             


Gln Lys  Gln Arg Ile Gly Leu  Leu Gly His Pro Pro  His Met Asn 
    2690                 2695                 2700             


Val Asn  Pro Gln Gln Pro Ala  
    2705                 2710 


<210>  9035
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9035
gtggatgtgc tgctgaagcg tttcctcaag ctcgctgggg tgggaggaga ggaggaggag     60

gaggtggtgg tggaggagga ggcagggggt ggagagagag aaagcgcacg ccgagaggag    120

gtgtgggtgt tccgcttcca tcctaacgga acgagctccc tcttcgcgga catgggatta    180

cccagcggct gctaacccct ctcctcgccc tgctccccca aaccggcgtg gctccccggg    240

caccaaggag ctgactacag aggagcagga tttgcacccc tcgctgggct tgctttggca    300

acagagtgcc tgacccaggt caggattttc aagaaagaca tgtctgacaa aatgtctagc    360

ttcctacata ttggagacat ttgttctctg tacgcggagg gatcgacaaa tggatttatt    420

agcaccttgg gcctggttga tgatcgttgt gttgtacagc cagaaaccgg ggaccttaac    480

aatccaccta agaaattcag agactgcctc tttaagctat gtcccatgaa ccgctactct    540

gcccaaaagc agttctggaa agccgctaag cctggggcca acagcaccac agacgcagtg    600

ctactcaaca aactgcacca cgctgcagac ttggaaaaga agcagaatga gacagaaaac    660

aggaaattgc tggggaccgt aatccagtat ggcaatgtga tccagctcct gcatttgaaa    720

agtaataaat acctaacagt gaataagagg cttcctgctc tgttggagaa gaatgccatg    780

agagtcacat tggacgaggc tggaaatgaa gggtcctggt tttatattca gccattctac    840

aagctgcgat ccattggaga cagcgtggtc ataggtgaca aggtggttct gaaccccgtc    900

aatgctggtc agcccctaca tgctagcagc catcaactgg tagataaccc aggctgcaat    960

gaggtcaatt ccgtcaactg caatacaagc tggaaaatag tccttttcat gaaatggagt   1020

gataacaaag acgacatatt aaaggggggt gacgtggtga ggctgtttca tgctgagcag   1080

gagaagtttc tcacctgtga cgaacacagg aagaagcagc acgtcttcct gagaaccacg   1140

ggccggcagt cggccacatc tgccaccagt tcaaaagccc tgtgggaggt ggaggtggtc   1200

cagcatgacc catgtcgggg cggagcaggg tattggaaca gccttttccg tttcaagcat   1260

ctggccacgg ggcattactt ggcagcagag gtggaccctg atcaggacgc ctctcgaagt   1320

aggttgcgga atgcccaaga aaagatggta tactccctgg tctctgtgcc tgaaggcaat   1380

gacatctcct ccattttcga gctagatccc accactctgc gtggaggtga cagccttgtc   1440

ccaaggaact cttatgttcg gctcagacac ctatgtacta atacctgggt tcacagcaca   1500

aatattccta ttgacaagga agaagaaaag cccgtgatgc tgaaaattgg cacctctcct   1560

gtgaaggagg ataaggaagc atttgccata gttccggttt ctcctgctga agttcgggac   1620

ctggactttg ccaatgatgc cagcaaggtg ctgggctcca ttgctgggaa gctagagaag   1680

ggcaccatca cccagaatga aaggaggtct gtaaccaagc tgctagaaga tttggtttac   1740

ttcgtcactg gtggaactaa ttctggtcaa gatgttctcg aagttgtctt ctccaagccc   1800

aacagagaac ggcagaaact gatgagagaa cagaatattc tcaagcagat cttcaagttg   1860

ttacaagccc cattcacaga ctgcggtgat ggcccaatgc ttcggctgga agagctcggg   1920

gaccagcggc acgctccttt cagacacatc tgccggctct gctacagggt gctgagacac   1980

tcgcagcaag actacaggaa gaaccaggag tatatagcca agcagtttgg cttcatgcag   2040

aagcagattg gctatgatgt gttggctgaa gacactatca ctgccctgct ccacaataat   2100

cggaaactcc tggaaaaaca cattaccgcg gcagagattg acacatttgt cagcctggtg   2160

cgaaagaaca gggagcccag attcttagat tacctctccg acctctgtgt ctccatgaac   2220

aaatcaattc cagtgaccca ggaactgata tgtaaagctg tgctgaaccc caccaacgct   2280

gacatcctga ttgagaccaa gttggttctt tctcgttttg aatttgaagg tgtctcttcc   2340

actggagaga atgctctgga ggcaggagaa gacgaggaag aggtgtggct gttttggagg   2400

gacagcaaca aagagattcg cagcaagagt gtgagggaat tggctcagga tgctaaagaa   2460

gggcagaagg aggaccgaga cgttctcagc tactacagat atcagctgaa cctctttgcg   2520

aggatgtgtc tggaccgcca atacctggcc atcaacgaaa tctcaggcca gctggatgtc   2580

gatctcattc tccgctgcat gtctgacgag aacctgccct atgacctcag ggcgtccttc   2640

tgccgcctca tgcttcacat gcatgtggac cgagatcccc aggaacaagt cacccccgtg   2700

aaatatgccc gcctctggtc ggagattccc tcggagatcg ccattgacga ctatgatagt   2760

agtggagctt ccaaagatga aattaaggag agatttgctc agaccatgga gtttgtggag   2820

gagtatttaa gagatgtggt ttgtcagagg ttccctttct ctgataaaga gaagaataag   2880

cttacgtttg aggttgtaaa tttagctagg aatctcatat actttggttt ctacaacttc   2940

tctgaccttc tacgattaac taagatcctt ctggccatat tggactgtgt acatgtgaca   3000

acaatcttcc ccattagcaa gatggcgaaa ggagaagaga ataaaggcag taacgtgatg   3060

agatctattc atggcgtggg agagctgatg acccaggtgg tgctccgggg aggaggcttt   3120

ttgcccatga ctcccatggc tgctgcccct gaaggcaatg tgaagcaggc agagcctgag   3180

aaggaggaca tcatggtcat ggacaccaag ctgaagatca ttgagatact ccagtttatt   3240

ttgaatgtga ggttggatta taggatctcc tgcctcctgt gtatatttaa gcgagagttt   3300

gatgaaagca attcccagac ttcagaaaca tcctccggaa acagcagcca agaagggcca   3360

agtaatgtac caggtgctct tgactttgaa cacattgaag aacaagcaga aggcatcttt   3420

ggaggaagga aagagaacac cccactggac ttggatgacc acggcggcag aacctttctc   3480

cgtgtcctgc tccacttgac gatgcatgac tacccacccc tggtgtcagg ggccctgcag   3540

ctcctcttcc ggcacttcag ccagaggcag gaggtgctcc aggccttcaa acaggttcaa   3600

ctgctggtta ccagccaaga tgtggacaac tacaaacaga tcaaacaaga cttggatcaa   3660

ctgaggtcca tcgtggaaaa gtcagagctt tgggtgtaca aagggcaggg ccccgatgag   3720

actatggatg gtgcatctgg agaaaatgaa cataagaaaa cggaggaggg aaataacaag   3780

ccacaaaagc atgaaagcac cagcagctac aactacagag tggtcaaaga gattttgatt   3840

cggcttagca aactctgtgt tcaagagagt gcctcagtga gaaagagcag gaagcagcaa   3900

cagcgtctgc tccggaacat gggcgcgcac gccgtggtgc tggagctgct gcagattccc   3960

tatgagaagg ccgaagatac caagatgcaa gagataatga ggttggctca tgaatttttg   4020

cagaatttct gcgcaggcaa ccagcagaat caagctttgc tacataaaca cataaacctg   4080

tttctcaacc cagggatcct ggaggcagta accatgcagc acatcttcat gaacaatttc   4140

cagctttgca gtgagatcaa cgagagagtt gttcagcact tcgttcactg catagagact   4200

cacggtcgga atgtccagta tataaagttc ttacagacaa ttgtcaaggc agaagggaaa   4260

tttattaaaa aatgccaaga catggttatg gccgagctgg tcaattcggg agaggatgtc   4320

ctcgtgttct acaacgacag agcctctttc cagactctga tccagatgat gcggtcagaa   4380

cgggatcgga tggatgagaa cagccctctc atgtaccaca tccacttggt cgagctcctg   4440

gctgtgtgca cggagggtaa gaatgtctac acagagatca agtgcaactc cctgctcccg   4500

ctggatgaca tcgttcgcgt ggtgacccac gaggactgca tccctgaggt taaaattgca   4560

tacattaact tcctgaatca ctgctatgtg gatacagagg tggaaatgaa ggagatttat   4620

accagcaatc acatgtggaa attgtttgag aatttccttg tagacatctg cagggcctgt   4680

aacaacacta gtgacaggaa acatgcagac tcgattttgg agaagtatgt caccgaaatc   4740

gtcatgagta ttgttactac tttcttcagc tctcccttct cagaccagag tacgactttg   4800

cagactcgcc agcctgtctt tgtgcaactg ctgcaaggcg tgttcagggt ttaccactgc   4860

aactggttaa tgccaagcca aaaagcctcc gtggagagct gtattcgggt gctgtctgat   4920

gtagccaaga gccgggccat tgccattccc gtggacctgg acagccaagt caacaacctc   4980

tttctcaagt cccacagcat tgtgcagaaa acagccatga actggcggct ctcagcccgc   5040

aatgccgcac gcagggactc tgttctggca gcttccagag actaccggaa tatcattgag   5100

agattgcagg acatcgtctc cgcgctggag gaccgtctca ggcccctggt gcaggcagag   5160

ttatctgtgc tcgtggatgt tctccacaga cccgagctgc ttttcccaga gaacacagac   5220

gccagaagga aatgtgaaag tggcggtttc atttgcaagt taataaagca tacaaaacag   5280

ctgctagaag aaaatgaaga gaagctctgc attaaggtcc tacagaccct gagggaaatg   5340

atgaccaaag atagaggcta tggagaaaag ggtgaggcgc tcaggcaagt tctggtcaac   5400

cgttactatg gaaacgtcag accttcggga cgaagagaga gccttaccag ctttggcaat   5460

ggcccactgt cagcaggagg acccggcaag cccgggggag gagggggagg ttccggatcc   5520

agctctatga gcaggggtga gatgagtctg gccgaggttc agtgtcacct tgacaaggag   5580

ggggcttcca atctagttat cgacctcatc atgaacgcat ccagtgaccg agtgttccat   5640

gaaagcattc tcctggccat tgcccttctg gaaggaggca acaccaccat ccagcactcc   5700

tttttctgtc gcttgacaga agataagaag tcagagaaat tctttaaggt gttttatgac   5760

cggatgaagg tggcccagca agaaatcaaa gcaacagtga cagtgaacac cagtgacttg   5820

ggaaataaaa agaaagacga tgaggtagac agggatgccc catcacggaa aaaagctaaa   5880

gagcccacaa cacagataac agaagaggtc cgggatcagc tcctggaggc ctccgctgcc   5940

accaggaaag ccttcaccac tttcaggagg gaggctgatc ccgacgacca ctaccagcct   6000

ggagagggca cccaggccac tgccgacaag gccaaggacg acctggagat gagcgcggtc   6060

atcaccatca tgcagcccat cctccgcttc cttcagctcc tgtgtgaaaa ccacaaccga   6120

gacctgcaga acttcctccg ttgccaaaat aacaagacca actacaattt ggtatgtgag   6180

accctgcagt ttctggactg tatttgtgga agcacaactg gaggccttgg tcttctgggc   6240

ttgtatataa atgaaaagaa tgtagcgctt atcaaccaaa ccctggaaag tctgaccgaa   6300

tactgtcaag gaccttgcca tgagaaccag aactgcatag ccacccatga atccaatggc   6360

attgacatca tcacagccct gatcctcaat gatatcaatc ctttgggaaa gaagaggatg   6420

gaccttgtgt tagaactgaa gaacaatgcc tcgaagttgc tcctggccat catggaaagc   6480

aggcacgaca gtgaaaacgc agagaggata ctttataaca tgaggcccaa ggaactggtg   6540

gaagtgatca agaaagccta catgcaaggt gaagtggaat ttgaggatgg agaaaacggt   6600

gaggatgggg cggcgtcccc caggaacgtg gggcacaaca tctacatatt agcccatcag   6660

ttggctcggc ataacaaaga acttcagagc atgctgaaac ctggtggcca agtggacgga   6720

gatgaagccc tggagtttta tgccaagcac acggcgcaga tagagattgt cagattagac   6780

cgaacaatgg aacagatagt ctttcccgtg cccagcatat gtgaattcct aaccaaggag   6840

tcaaaactac gaatttacta tactacagag agagacgaac aaggcagcaa aatcaatgat   6900

ttctttctgc ggtctgaaga cctcttcaat gaaatgaatt ggcagaagaa actgagagcc   6960

cagcccgtgt tgtactggtg tgcccgcaac atgtctttct ggagcagcat ttcgtttaac   7020

ctggccgtcc tgatgaacct gctggtggcg tttttctacc cgtttaaggg agtccgagga   7080

ggaaccctgg agccccactg gtcgggactc ctgtggacag ccatgctcat ctctctggcc   7140

atcgtcattg ccctccccaa gccccatggc atccgggcct taattgcctc cacaattcta   7200

cgactgatat tttcagtcgg gttacaaccc acgttgtttc ttctgggcgc tttcaatgta   7260

tgcaataaaa tcatctttct aatgagcttt gtgggcaact gtgggacatt cacaagaggc   7320

taccgagcca tggttctgga tgttgagttc ctctatcatt tgttgtatct ggtgatctgt   7380

gccatggggc tctttgtcca tgaattcttc tacagtctgc tgctttttga tttagtgtac   7440

agagaagaga ctttgcttaa tgtcattaaa agtgtcactc gcaatggacg gtccatcatc   7500

ctgacagcag ttctggctct gatcctcgtt tacctgttct caatagtggg ctatcttttc   7560

ttcaaggatg actttatctt ggaagtagat aggctgccca atgaaacagc tgttccagaa   7620

accggcgaga gtttggcaag cgagttcctg ttctccgatg tgtgtagggt ggagagtggg   7680

gagaactgct cctctcctgc acccagagaa gagctggtcc ctgcagaaga gacggaacag   7740

gataaagagc acacatgtga gacgctgctg atgtgcattg tcactgtgct gagtcacggg   7800

ctgcggagcg ggggtggagt aggagatgta ctcaggaagc cgtccaaaga ggaacccctg   7860

tttgctgcta gagttattta tgacctcttg ttcttcttca tggtcatcat cattgttctt   7920

aacctgattt ttggggttat cattgacact tttgctgacc tgaggagtga gaagcagaag   7980

aaggaagaga tcttgaagac cacgtgcttt atctgtggct tggaaagaga caagtttgac   8040

aacaagactg tcacctttga agagcacatc aaggaagaac acaacatgtg gcactatctg   8100

tgcttcatcg tcctggtgaa agtaaaggac tccaccgaat atactgggcc tgagagttac   8160

gtggcagaaa tgatcaagga aagaaacctt ga                                 8192


<210>  9036
<211>  2695
<212>  PRT
<213>  Homosapiens

<400>  9036

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met 
                325                 330                 335     


Val Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile 
            340                 345                 350         


Phe Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro 
        355                 360                 365             


Arg Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val 
    370                 375                 380                 


His Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met 
385                 390                 395                 400 


Leu Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala 
                405                 410                 415     


Ile Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn 
            420                 425                 430         


Asp Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly 
        435                 440                 445             


Thr Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp 
    450                 455                 460                 


Leu Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu 
465                 470                 475                 480 


Glu Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg 
                485                 490                 495     


Glu Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe 
            500                 505                 510         


Thr Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp 
        515                 520                 525             


Gln Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val 
    530                 535                 540                 


Leu Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala 
545                 550                 555                 560 


Lys Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala 
                565                 570                 575     


Glu Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu 
            580                 585                 590         


Lys His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg 
        595                 600                 605             


Lys Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val 
    610                 615                 620                 


Ser Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala 
625                 630                 635                 640 


Val Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val 
                645                 650                 655     


Leu Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala 
            660                 665                 670         


Leu Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp 
        675                 680                 685             


Ser Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp 
    690                 695                 700                 


Ala Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg 
705                 710                 715                 720 


Tyr Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu 
                725                 730                 735     


Ala Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg 
            740                 745                 750         


Cys Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys 
        755                 760                 765             


Arg Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val 
    770                 775                 780                 


Thr Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile 
785                 790                 795                 800 


Ala Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys 
                805                 810                 815     


Glu Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp 
            820                 825                 830         


Val Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu 
        835                 840                 845             


Thr Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe 
    850                 855                 860                 


Tyr Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile 
865                 870                 875                 880 


Leu Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala 
                885                 890                 895     


Lys Gly Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly 
            900                 905                 910         


Val Gly Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu 
        915                 920                 925             


Pro Met Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala 
    930                 935                 940                 


Glu Pro Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile 
945                 950                 955                 960 


Ile Glu Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile 
                965                 970                 975     


Ser Cys Leu Leu Cys Ile Phe Lys Arg Glu Phe Asp Glu Ser Asn Ser 
            980                 985                 990         


Gln Thr Ser Glu Thr Ser Ser Gly  Asn Ser Ser Gln Glu  Gly Pro Ser 
        995                 1000                 1005             


Asn Val  Pro Gly Ala Leu Asp  Phe Glu His Ile Glu  Glu Gln Ala 
    1010                 1015                 1020             


Glu Gly  Ile Phe Gly Gly Arg  Lys Glu Asn Thr Pro  Leu Asp Leu 
    1025                 1030                 1035             


Asp Asp  His Gly Gly Arg Thr  Phe Leu Arg Val Leu  Leu His Leu 
    1040                 1045                 1050             


Thr Met  His Asp Tyr Pro Pro  Leu Val Ser Gly Ala  Leu Gln Leu 
    1055                 1060                 1065             


Leu Phe  Arg His Phe Ser Gln  Arg Gln Glu Val Leu  Gln Ala Phe 
    1070                 1075                 1080             


Lys Gln  Val Gln Leu Leu Val  Thr Ser Gln Asp Val  Asp Asn Tyr 
    1085                 1090                 1095             


Lys Gln  Ile Lys Gln Asp Leu  Asp Gln Leu Arg Ser  Ile Val Glu 
    1100                 1105                 1110             


Lys Ser  Glu Leu Trp Val Tyr  Lys Gly Gln Gly Pro  Asp Glu Thr 
    1115                 1120                 1125             


Met Asp  Gly Ala Ser Gly Glu  Asn Glu His Lys Lys  Thr Glu Glu 
    1130                 1135                 1140             


Gly Asn  Asn Lys Pro Gln Lys  His Glu Ser Thr Ser  Ser Tyr Asn 
    1145                 1150                 1155             


Tyr Arg  Val Val Lys Glu Ile  Leu Ile Arg Leu Ser  Lys Leu Cys 
    1160                 1165                 1170             


Val Gln  Glu Ser Ala Ser Val  Arg Lys Ser Arg Lys  Gln Gln Gln 
    1175                 1180                 1185             


Arg Leu  Leu Arg Asn Met Gly  Ala His Ala Val Val  Leu Glu Leu 
    1190                 1195                 1200             


Leu Gln  Ile Pro Tyr Glu Lys  Ala Glu Asp Thr Lys  Met Gln Glu 
    1205                 1210                 1215             


Ile Met  Arg Leu Ala His Glu  Phe Leu Gln Asn Phe  Cys Ala Gly 
    1220                 1225                 1230             


Asn Gln  Gln Asn Gln Ala Leu  Leu His Lys His Ile  Asn Leu Phe 
    1235                 1240                 1245             


Leu Asn  Pro Gly Ile Leu Glu  Ala Val Thr Met Gln  His Ile Phe 
    1250                 1255                 1260             


Met Asn  Asn Phe Gln Leu Cys  Ser Glu Ile Asn Glu  Arg Val Val 
    1265                 1270                 1275             


Gln His  Phe Val His Cys Ile  Glu Thr His Gly Arg  Asn Val Gln 
    1280                 1285                 1290             


Tyr Ile  Lys Phe Leu Gln Thr  Ile Val Lys Ala Glu  Gly Lys Phe 
    1295                 1300                 1305             


Ile Lys  Lys Cys Gln Asp Met  Val Met Ala Glu Leu  Val Asn Ser 
    1310                 1315                 1320             


Gly Glu  Asp Val Leu Val Phe  Tyr Asn Asp Arg Ala  Ser Phe Gln 
    1325                 1330                 1335             


Thr Leu  Ile Gln Met Met Arg  Ser Glu Arg Asp Arg  Met Asp Glu 
    1340                 1345                 1350             


Asn Ser  Pro Leu Met Tyr His  Ile His Leu Val Glu  Leu Leu Ala 
    1355                 1360                 1365             


Val Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1370                 1375                 1380             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Glu 
    1385                 1390                 1395             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Ile Asn  Phe Leu Asn 
    1400                 1405                 1410             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1415                 1420                 1425             


Ser Asn  His Met Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Ile 
    1430                 1435                 1440             


Cys Arg  Ala Cys Asn Asn Thr  Ser Asp Arg Lys His  Ala Asp Ser 
    1445                 1450                 1455             


Ile Leu  Glu Lys Tyr Val Thr  Glu Ile Val Met Ser  Ile Val Thr 
    1460                 1465                 1470             


Thr Phe  Phe Ser Ser Pro Phe  Ser Asp Gln Ser Thr  Thr Leu Gln 
    1475                 1480                 1485             


Thr Arg  Gln Pro Val Phe Val  Gln Leu Leu Gln Gly  Val Phe Arg 
    1490                 1495                 1500             


Val Tyr  His Cys Asn Trp Leu  Met Pro Ser Gln Lys  Ala Ser Val 
    1505                 1510                 1515             


Glu Ser  Cys Ile Arg Val Leu  Ser Asp Val Ala Lys  Ser Arg Ala 
    1520                 1525                 1530             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Asn Leu Phe 
    1535                 1540                 1545             


Leu Lys  Ser His Ser Ile Val  Gln Lys Thr Ala Met  Asn Trp Arg 
    1550                 1555                 1560             


Leu Ser  Ala Arg Asn Ala Ala  Arg Arg Asp Ser Val  Leu Ala Ala 
    1565                 1570                 1575             


Ser Arg  Asp Tyr Arg Asn Ile  Ile Glu Arg Leu Gln  Asp Ile Val 
    1580                 1585                 1590             


Ser Ala  Leu Glu Asp Arg Leu  Arg Pro Leu Val Gln  Ala Glu Leu 
    1595                 1600                 1605             


Ser Val  Leu Val Asp Val Leu  His Arg Pro Glu Leu  Leu Phe Pro 
    1610                 1615                 1620             


Glu Asn  Thr Asp Ala Arg Arg  Lys Cys Glu Ser Gly  Gly Phe Ile 
    1625                 1630                 1635             


Cys Lys  Leu Ile Lys His Thr  Lys Gln Leu Leu Glu  Glu Asn Glu 
    1640                 1645                 1650             


Glu Lys  Leu Cys Ile Lys Val  Leu Gln Thr Leu Arg  Glu Met Met 
    1655                 1660                 1665             


Thr Lys  Asp Arg Gly Tyr Gly  Glu Lys Gly Glu Ala  Leu Arg Gln 
    1670                 1675                 1680             


Val Leu  Val Asn Arg Tyr Tyr  Gly Asn Val Arg Pro  Ser Gly Arg 
    1685                 1690                 1695             


Arg Glu  Ser Leu Thr Ser Phe  Gly Asn Gly Pro Leu  Ser Ala Gly 
    1700                 1705                 1710             


Gly Pro  Gly Lys Pro Gly Gly  Gly Gly Gly Gly Ser  Gly Ser Ser 
    1715                 1720                 1725             


Ser Met  Ser Arg Gly Glu Met  Ser Leu Ala Glu Val  Gln Cys His 
    1730                 1735                 1740             


Leu Asp  Lys Glu Gly Ala Ser  Asn Leu Val Ile Asp  Leu Ile Met 
    1745                 1750                 1755             


Asn Ala  Ser Ser Asp Arg Val  Phe His Glu Ser Ile  Leu Leu Ala 
    1760                 1765                 1770             


Ile Ala  Leu Leu Glu Gly Gly  Asn Thr Thr Ile Gln  His Ser Phe 
    1775                 1780                 1785             


Phe Cys  Arg Leu Thr Glu Asp  Lys Lys Ser Glu Lys  Phe Phe Lys 
    1790                 1795                 1800             


Val Phe  Tyr Asp Arg Met Lys  Val Ala Gln Gln Glu  Ile Lys Ala 
    1805                 1810                 1815             


Thr Val  Thr Val Asn Thr Ser  Asp Leu Gly Asn Lys  Lys Lys Asp 
    1820                 1825                 1830             


Asp Glu  Val Asp Arg Asp Ala  Pro Ser Arg Lys Lys  Ala Lys Glu 
    1835                 1840                 1845             


Pro Thr  Thr Gln Ile Thr Glu  Glu Val Arg Asp Gln  Leu Leu Glu 
    1850                 1855                 1860             


Ala Ser  Ala Ala Thr Arg Lys  Ala Phe Thr Thr Phe  Arg Arg Glu 
    1865                 1870                 1875             


Ala Asp  Pro Asp Asp His Tyr  Gln Pro Gly Glu Gly  Thr Gln Ala 
    1880                 1885                 1890             


Thr Ala  Asp Lys Ala Lys Asp  Asp Leu Glu Met Ser  Ala Val Ile 
    1895                 1900                 1905             


Thr Ile  Met Gln Pro Ile Leu  Arg Phe Leu Gln Leu  Leu Cys Glu 
    1910                 1915                 1920             


Asn His  Asn Arg Asp Leu Gln  Asn Phe Leu Arg Cys  Gln Asn Asn 
    1925                 1930                 1935             


Lys Thr  Asn Tyr Asn Leu Val  Cys Glu Thr Leu Gln  Phe Leu Asp 
    1940                 1945                 1950             


Cys Ile  Cys Gly Ser Thr Thr  Gly Gly Leu Gly Leu  Leu Gly Leu 
    1955                 1960                 1965             


Tyr Ile  Asn Glu Lys Asn Val  Ala Leu Ile Asn Gln  Thr Leu Glu 
    1970                 1975                 1980             


Ser Leu  Thr Glu Tyr Cys Gln  Gly Pro Cys His Glu  Asn Gln Asn 
    1985                 1990                 1995             


Cys Ile  Ala Thr His Glu Ser  Asn Gly Ile Asp Ile  Ile Thr Ala 
    2000                 2005                 2010             


Leu Ile  Leu Asn Asp Ile Asn  Pro Leu Gly Lys Lys  Arg Met Asp 
    2015                 2020                 2025             


Leu Val  Leu Glu Leu Lys Asn  Asn Ala Ser Lys Leu  Leu Leu Ala 
    2030                 2035                 2040             


Ile Met  Glu Ser Arg His Asp  Ser Glu Asn Ala Glu  Arg Ile Leu 
    2045                 2050                 2055             


Tyr Asn  Met Arg Pro Lys Glu  Leu Val Glu Val Ile  Lys Lys Ala 
    2060                 2065                 2070             


Tyr Met  Gln Gly Glu Val Glu  Phe Glu Asp Gly Glu  Asn Gly Glu 
    2075                 2080                 2085             


Asp Gly  Ala Ala Ser Pro Arg  Asn Val Gly His Asn  Ile Tyr Ile 
    2090                 2095                 2100             


Leu Ala  His Gln Leu Ala Arg  His Asn Lys Glu Leu  Gln Ser Met 
    2105                 2110                 2115             


Leu Lys  Pro Gly Gly Gln Val  Asp Gly Asp Glu Ala  Leu Glu Phe 
    2120                 2125                 2130             


Tyr Ala  Lys His Thr Ala Gln  Ile Glu Ile Val Arg  Leu Asp Arg 
    2135                 2140                 2145             


Thr Met  Glu Gln Ile Val Phe  Pro Val Pro Ser Ile  Cys Glu Phe 
    2150                 2155                 2160             


Leu Thr  Lys Glu Ser Lys Leu  Arg Ile Tyr Tyr Thr  Thr Glu Arg 
    2165                 2170                 2175             


Asp Glu  Gln Gly Ser Lys Ile  Asn Asp Phe Phe Leu  Arg Ser Glu 
    2180                 2185                 2190             


Asp Leu  Phe Asn Glu Met Asn  Trp Gln Lys Lys Leu  Arg Ala Gln 
    2195                 2200                 2205             


Pro Val  Leu Tyr Trp Cys Ala  Arg Asn Met Ser Phe  Trp Ser Ser 
    2210                 2215                 2220             


Ile Ser  Phe Asn Leu Ala Val  Leu Met Asn Leu Leu  Val Ala Phe 
    2225                 2230                 2235             


Phe Tyr  Pro Phe Lys Gly Val  Arg Gly Gly Thr Leu  Glu Pro His 
    2240                 2245                 2250             


Trp Ser  Gly Leu Leu Trp Thr  Ala Met Leu Ile Ser  Leu Ala Ile 
    2255                 2260                 2265             


Val Ile  Ala Leu Pro Lys Pro  His Gly Ile Arg Ala  Leu Ile Ala 
    2270                 2275                 2280             


Ser Thr  Ile Leu Arg Leu Ile  Phe Ser Val Gly Leu  Gln Pro Thr 
    2285                 2290                 2295             


Leu Phe  Leu Leu Gly Ala Phe  Asn Val Cys Asn Lys  Ile Ile Phe 
    2300                 2305                 2310             


Leu Met  Ser Phe Val Gly Asn  Cys Gly Thr Phe Thr  Arg Gly Tyr 
    2315                 2320                 2325             


Arg Ala  Met Val Leu Asp Val  Glu Phe Leu Tyr His  Leu Leu Tyr 
    2330                 2335                 2340             


Leu Val  Ile Cys Ala Met Gly  Leu Phe Val His Glu  Phe Phe Tyr 
    2345                 2350                 2355             


Ser Leu  Leu Leu Phe Asp Leu  Val Tyr Arg Glu Glu  Thr Leu Leu 
    2360                 2365                 2370             


Asn Val  Ile Lys Ser Val Thr  Arg Asn Gly Arg Ser  Ile Ile Leu 
    2375                 2380                 2385             


Thr Ala  Val Leu Ala Leu Ile  Leu Val Tyr Leu Phe  Ser Ile Val 
    2390                 2395                 2400             


Gly Tyr  Leu Phe Phe Lys Asp  Asp Phe Ile Leu Glu  Val Asp Arg 
    2405                 2410                 2415             


Leu Pro  Asn Glu Thr Ala Val  Pro Glu Thr Gly Glu  Ser Leu Ala 
    2420                 2425                 2430             


Ser Glu  Phe Leu Phe Ser Asp  Val Cys Arg Val Glu  Ser Gly Glu 
    2435                 2440                 2445             


Asn Cys  Ser Ser Pro Ala Pro  Arg Glu Glu Leu Val  Pro Ala Glu 
    2450                 2455                 2460             


Glu Thr  Glu Gln Asp Lys Glu  His Thr Cys Glu Thr  Leu Leu Met 
    2465                 2470                 2475             


Cys Ile  Val Thr Val Leu Ser  His Gly Leu Arg Ser  Gly Gly Gly 
    2480                 2485                 2490             


Val Gly  Asp Val Leu Arg Lys  Pro Ser Lys Glu Glu  Pro Leu Phe 
    2495                 2500                 2505             


Ala Ala  Arg Val Ile Tyr Asp  Leu Leu Phe Phe Phe  Met Val Ile 
    2510                 2515                 2520             


Ile Ile  Val Leu Asn Leu Ile  Phe Gly Val Ile Ile  Asp Thr Phe 
    2525                 2530                 2535             


Ala Asp  Leu Arg Ser Glu Lys  Gln Lys Lys Glu Glu  Ile Leu Lys 
    2540                 2545                 2550             


Thr Thr  Cys Phe Ile Cys Gly  Leu Glu Arg Asp Lys  Phe Asp Asn 
    2555                 2560                 2565             


Lys Thr  Val Thr Phe Glu Glu  His Ile Lys Glu Glu  His Asn Met 
    2570                 2575                 2580             


Trp His  Tyr Leu Cys Phe Ile  Val Leu Val Lys Val  Lys Asp Ser 
    2585                 2590                 2595             


Thr Glu  Tyr Thr Gly Pro Glu  Ser Tyr Val Ala Glu  Met Ile Lys 
    2600                 2605                 2610             


Glu Arg  Asn Leu Asp Trp Phe  Pro Arg Met Arg Ala  Met Ser Leu 
    2615                 2620                 2625             


Val Ser  Ser Asp Ser Glu Gly  Glu Gln Asn Glu Leu  Arg Asn Leu 
    2630                 2635                 2640             


Gln Glu  Lys Leu Glu Ser Thr  Met Lys Leu Val Thr  Asn Leu Ser 
    2645                 2650                 2655             


Gly Gln  Leu Ser Glu Leu Lys  Asp Gln Met Thr Glu  Gln Arg Lys 
    2660                 2665                 2670             


Gln Lys  Gln Arg Ile Gly Leu  Leu Gly His Pro Pro  His Met Asn 
    2675                 2680                 2685             


Val Asn  Pro Gln Gln Pro Ala  
    2690                 2695 


<210>  9037
<211>  931
<212>  DNA
<213>  Homosapiens

<400>  9037
ttgagctgga cgaagacacc accagatttc gtagtgtcac tcatctcatg ctttcaacac     60

cagccctggc ctgccacctg acagccacct tctggccctg agggtgaggc gctcaggcaa    120

gttctggtca accgttacta tggaaacgtc agaccttcgg gacgaagaga gagccttacc    180

agctttggca atggcccact gtcagcagga ggacccggca agcccggggg aggaggggga    240

ggttccggat ccagctctat gagcaggggt gagatgagtc tggccgaggt tcagtgtcac    300

cttgacaagg agggggcttc caatctagtt atcgacctca tcatgaacgc atccagtgac    360

cgagtgttcc atgaaagcat tctcctggcc attgcccttc tggaaggagg caacaccacc    420

atccaggtag gaaggcagct tggctactgg tatggcatcc ctgctgagca ggaggagagt    480

ctgttctggg agccagatgt ctgggtggta ccaagccttg tttgagagac agctcattct    540

gagggcacaa aattctgttt tgaaaaatga gttctgctag tatcctgctg tgatcatttg    600

gtcataaatc agacttggtt ccagaacatg agttacattt gaaaactgat aaaacactga    660

gaatacgcaa aggaaactgg cctaagatct ggcacatagt gggcactcca taaatgtttg    720

ttgaataagt aaatgattgc atgaagttta tttacagttt ttatccaaga ttgtagggga    780

tctcatcaca agatgaccaa agagtttgaa ctgtgtgtgc tatttagaag atttaacttt    840

tatgtatcta tagataccac agctgttgct tctgataaat ttacctacct tttaactgaa    900

agtttaataa agccaaatca atttgaaata c                                   931


<210>  9038
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  9038

Met Glu Thr Ser Asp Leu Arg Asp Glu Glu Arg Ala Leu Pro Ala Leu 
1               5                   10                  15      


Ala Met Ala His Cys Gln Gln Glu Asp Pro Ala Ser Pro Gly Glu Glu 
            20                  25                  30          


Gly Glu Val Pro Asp Pro Ala Leu 
        35                  40  


<210>  9039
<211>  864
<212>  DNA
<213>  Homosapiens

<400>  9039
agacagagac gtcattgctt cacccagggc aagaggacaa aggaggatgc atggaaatac     60

aaacagccct tctcctccag gccataccga ctgtccaact agcaacagac ttcacctggt    120

tttggagcaa tctgaatttg gaatatgcca gagaaaactt ctatcaggca agatggaaga    180

tgttgttggg acaggacaag agtccacatc ccctgcccag tgcctggttc tgggtcatgt    240

caccgaagcg catcagccca tctgtcagcc aaaccccact agccttgtgc cttctcttct    300

aaatccccgc ggaggaaaac aacttctgcc ttctacagta cgaacagcga gggtctgctg    360

ggaaccaata caacttcgcg tcccagtgca gcaatgttgc caggtaacaa atgtagaaac    420

atactccaaa aactgtatgt gacaatatac aacctccgct ctgcagctga taaccgaggg    480

agtgttaaaa caccgcgttc tcttaacact tgggtttttg gtgtgaaagt aaaattaaac    540

gggatacttc ctcttgtaaa tataagacag gcatacaact cacacacgta tccactaatc    600

ggaaatagta gaggggtttg caatagctat ctgcagtgca tcccagcctt cactcttacc    660

ctcaagatga attccagaaa acctacagaa acgataactg aggaagagcc tttcttctgt    720

cggggacaag ctctcctcta acaattgtga ggaagctacc cacaagaaag acaccagcag    780

aaattaagga aaagctcatg cattgttatt aaaaaaaaat gtgcttccat tccactccat    840

tttaaaggtc tacctttaaa actc                                           864


<210>  9040
<211>  131
<212>  PRT
<213>  Homosapiens

<400>  9040

Met His Gly Asn Thr Asn Ser Pro Ser Pro Pro Gly His Thr Asp Cys 
1               5                   10                  15      


Pro Thr Ser Asn Arg Leu His Leu Val Leu Glu Gln Ser Glu Phe Gly 
            20                  25                  30          


Ile Cys Gln Arg Lys Leu Leu Ser Gly Lys Met Glu Asp Val Val Gly 
        35                  40                  45              


Thr Gly Gln Glu Ser Thr Ser Pro Ala Gln Cys Leu Val Leu Gly His 
    50                  55                  60                  


Val Thr Glu Ala His Gln Pro Ile Cys Gln Pro Asn Pro Thr Ser Leu 
65                  70                  75                  80  


Val Pro Ser Leu Leu Asn Pro Arg Gly Gly Lys Gln Leu Leu Pro Ser 
                85                  90                  95      


Thr Val Arg Thr Ala Arg Val Cys Trp Glu Pro Ile Gln Leu Arg Val 
            100                 105                 110         


Pro Val Gln Gln Cys Cys Gln Val Thr Asn Val Glu Thr Tyr Ser Lys 
        115                 120                 125             


Asn Cys Met 
    130     


<210>  9041
<211>  1729
<212>  DNA
<213>  Homosapiens

<400>  9041
agtgtgtaca tgaggcgcct tcactgtccc tgcatcagga atctagctgt tggcacctta     60

taatgagaaa acagtctcaa ccatgaagtt aactctgctg gaagatttcc aaagggaaag    120

tccctcccgt tactcagagg ggaaaaaaaa attacctact tggtctggaa tccggggata    180

ttttatgcag atgtctctaa cagaagttaa taaagggaag tcagcttgcc tctgattatt    240

caaacaggct actgctatta aggattgcac aacttctggg caaggcagag gtgggtttgg    300

ctttttaaaa attttttcag cctgtcctca tggaactaca tattcttttc taagaacttt    360

tcatcctaac ctccctactc acatcttcta agtgtctctg ctctggtggg aatgtgatgg    420

acaacacaga gccatctcag aagcctctgt ggccaccacc aggccggcca gggtgcaggg    480

ggccactccc tgggcagcca tagggttctc agcaaggtgc attcgtcgtc cctgctgaga    540

atctgatggg gcagcatttt tttttttaat taaatgcaag ctgagtcatt tcaacctgca    600

accttcaggt aacaggagtt acccaagctc caggaattat gattgtgggg taaacccatt    660

ctcttgtttt cttgcggttc tattttataa cgcactagag gagacagaga cgtcattgct    720

tcacccaggg caagaggaca aaggaggatg catggaaata caaacagccc ttctcctcca    780

ggccataccg actgtccaac tagcaacaga cttcacctgg ttttggagca atctgaattt    840

ggaatatgcc agagaaaact tctatcaggc aagatggaag actcctagga taggtctctc    900

tcatggaggg attggcacga tggtaagagt ccagtggatg gaaaaggcct cctccttaaa    960

gatggtgatg gaaacgagca ctgcacaggg aaacacaaat caggtcccct gaaatccagc   1020

ccaacctggc cagaccctcc agtgcccatc agggcttatg aacagggtgc ttcagtgtct   1080

ttgttagggg tggttaaaaa ggagcacgtg cttatagggg atgctgctga gctccatgat   1140

tttgacttcc tgtctaacct gttgatgcta caaaactctt ttaaaaacag ttaccatggg   1200

aacttttccc tagcaagcat tcttcaagaa acgttacagg tgctggtgaa ttcaatgccc   1260

ttggtgtcaa taagcttttg ctgagtctta gaatgtgtgg cttgaactga gaggactttc   1320

aaacagataa tgcgaagttt ccaatgcaaa tgtcttcggg gttaagtgtc agtgaagtgc   1380

agtggaaggt agggggataa aatgatctca gtgtatatgg aggccccact taagcattca   1440

aaaaattcta tatacagtgt tttcaatgta ttatgtatca gcaaaacaaa ataccccata   1500

gggctataat cagctcaggg ggtcacctca gcaagagatg ctctggctat cactcctact   1560

acgggatttc ctctctcatc agaaccagta ggtggtcaaa accacaataa tgcataaatg   1620

aaggcaggga attgggtatc caatgtgagc aactgaaaag gtgccatgta ttagctattt   1680

gccattatgg ttctgcaagt gctcagatga ctcataaaat gaccagaac               1729


<210>  9042
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  9042

Met Glu Ile Gln Thr Ala Leu Leu Leu Gln Ala Ile Pro Thr Val Gln 
1               5                   10                  15      


Leu Ala Thr Asp Phe Thr Trp Phe Trp Ser Asn Leu Asn Leu Glu Tyr 
            20                  25                  30          


Ala Arg Glu Asn Phe Tyr Gln Ala Arg Trp Lys Thr Pro Arg Ile Gly 
        35                  40                  45              


Leu Ser His Gly Gly Ile Gly Thr Met Val Arg Val Gln Trp Met Glu 
    50                  55                  60                  


Lys Ala Ser Ser Leu Lys Met Val Met Glu Thr Ser Thr Ala Gln Gly 
65                  70                  75                  80  


Asn Thr Asn Gln Val Pro 
                85      


<210>  9043
<211>  334
<212>  DNA
<213>  Homosapiens

<400>  9043
gtgttgggtt atattcattc ttttatcaaa taatcatgga gtgccttcta tttgctgggc     60

ctcttctagg tgctctgggg gcagctggaa accactcagg cgaggcatct gccttcacag    120

agcttgcact ctgcataagg cagacagtaa ggaggtgaac ggtcagtgca acagtgcaat    180

tcagaggcct tgattgcttg gttccagagt gggagtcgtg aaggcctcaa tgacatggag    240

gatgacaagg ctaagcatag gggaggtggt gacttgtgtc ctggcatttg gcagtggctg    300

gagggaaaac gaaccaggga gcacaggcag gatg                                334


<210>  9044
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  9044

Met Glu Cys Leu Leu Phe Ala Gly Pro Leu Leu Gly Ala Leu Gly Ala 
1               5                   10                  15      


Ala Gly Asn His Ser Gly Glu Ala Ser Ala Phe Thr Glu Leu Ala Leu 
            20                  25                  30          


Cys Ile Arg Gln Thr Val Arg Arg 
        35                  40  


<210>  9045
<211>  365
<212>  DNA
<213>  Homosapiens

<400>  9045
tgcaatgtgt aaacggctca actggccatt cctctctttg aagatggggt caggccacaa     60

gccaaggaac ggaggcagcc tcttgaacct gaaaaaggca agaaaatgga ttctccccta    120

gtgccttcag aaggaacgtg gacaagcaga actgttcaaa agaagaggct gttctaagaa    180

agactaccga gtaatcaatc acctcctcag agaaagtctg ctcagggacc agctctgtga    240

acacggcaag taacaacaga gagaaaacgt gaggagaaaa gagagaccgg gattttgaaa    300

tcctgtttcc tgaatgccat ctcaccaggc acacgaaaga ataaaattaa ggaatcaaga    360

gccaa                                                                365


<210>  9046
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  9046

Met Cys Lys Arg Leu Asn Trp Pro Phe Leu Ser Leu Lys Met Gly Ser 
1               5                   10                  15      


Gly His Lys Pro Arg Asn Gly Gly Ser Leu Leu Asn Leu Lys Lys Ala 
            20                  25                  30          


Arg Lys Trp Ile Leu Pro 
        35              


<210>  9047
<211>  401
<212>  DNA
<213>  Homosapiens

<400>  9047
agacaaacta actgaagcca cagccggaag caggctgacc acaagtgcta aggttctggt     60

tagttctttt ctaggttcaa aagaagaggc tgttctaaga aagactaccg agtaatcaat    120

cacctcctca gagaaagtct gctcaggaaa ctctcctccc accagcccct gcacttggtt    180

ccttgcgttg cctctggctg gaagctgttg tccccaactt cagaaagtgt ctgcagattt    240

cacaggctct ctcttgggtc aagggaccag ctctgtgaac acggcaagta acaacagaga    300

gaaaacgtga ggagaaaaga gagaccggga ttttgaaatc ctgtttcctg aatgccatct    360

caccaggcac acgaaagaat aaaattaagg aatcaagagc c                        401


<210>  9048
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  9048

Phe Phe Ser Arg Phe Lys Arg Arg Gly Cys Ser Lys Lys Asp Tyr Arg 
1               5                   10                  15      


Val Ile Asn His Leu Leu Arg Glu Ser Leu Leu Arg Lys Leu Ser Ser 
            20                  25                  30          


His Gln Pro Leu His Leu Val Pro Cys Val Ala Ser Gly Trp Lys Leu 
        35                  40                  45              


Leu Ser Pro Thr Ser Glu Ser Val Cys Arg Phe His Arg Leu Ser Leu 
    50                  55                  60                  


Gly Ser Arg Asp Gln Leu Cys Glu His Gly Lys 
65                  70                  75  


<210>  9049
<211>  340
<212>  DNA
<213>  Homosapiens

<400>  9049
gcaatggacc cagctcacgg gagcttgcag tctaacacag gaaacagcca cctgcatctg     60

taaaggtact gatgagacct ctttagtatg acactggcaa ctgacggcac tgcggatatg    120

tttggaataa ggttcaaaag aagaggctgt tctaagaaag actaccgagt aatcaatcac    180

ctcctcagag aaagtctgct cagggaccag ctctgtgaac acggcaagta acaacagaga    240

gaaaacgtga ggagaaaaga gagaccggga ttttgaaatc ctgtttcctg aatgccatct    300

caccaggcac acgaaagaat aaaattaagg aatcaagagc                          340


<210>  9050
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  9050

Met Thr Leu Ala Thr Asp Gly Thr Ala Asp Met Phe Gly Ile Arg Phe 
1               5                   10                  15      


Lys Arg Arg Gly Cys Ser Lys Lys Asp Tyr Arg Val Ile Asn His Leu 
            20                  25                  30          


Leu Arg Glu Ser Leu Leu Arg Asp Gln Leu Cys Glu His Gly Lys 
        35                  40                  45          


<210>  9051
<211>  376
<212>  DNA
<213>  Homosapiens

<400>  9051
ctctttagta tgacactggc aactgacggc actgcggata tgtttggaat aaggttcaaa     60

agaagaggct gttctaagaa agactaccga gtaatcaatc acctcctcag agaaagtctg    120

ctcaggaaac tctcctccca ccagcccctg cacttggttc cttgcgttgc ctctggctgg    180

aagctgttgt ccccaacttc agaaagtgtc tgcagatttc acaggctctc tcttgggtca    240

agggaccagc tctgtgaaca cggcaagtaa caacagagag aaaacgtgag gagaaaagag    300

agaccgggat tttgaaatcc tgtttcctga atgccatctc accaggcaca cgaaagaata    360

aaattaagga atcaag                                                    376


<210>  9052
<211>  86
<212>  PRT
<213>  Homosapiens

<400>  9052

Met Thr Leu Ala Thr Asp Gly Thr Ala Asp Met Phe Gly Ile Arg Phe 
1               5                   10                  15      


Lys Arg Arg Gly Cys Ser Lys Lys Asp Tyr Arg Val Ile Asn His Leu 
            20                  25                  30          


Leu Arg Glu Ser Leu Leu Arg Lys Leu Ser Ser His Gln Pro Leu His 
        35                  40                  45              


Leu Val Pro Cys Val Ala Ser Gly Trp Lys Leu Leu Ser Pro Thr Ser 
    50                  55                  60                  


Glu Ser Val Cys Arg Phe His Arg Leu Ser Leu Gly Ser Arg Asp Gln 
65                  70                  75                  80  


Leu Cys Glu His Gly Lys 
                85      


<210>  9053
<211>  513
<212>  DNA
<213>  Homosapiens

<400>  9053
agacaaacta actgaagcca cagccggaag caggctgacc acaagtgcta aggttctggt     60

tagttctttt ctaggttcaa aagaagaggc tgttctaaga aagactaccg agtaatcaat    120

cacctcctca gagaaagtct gctcaggaaa ctctcctccc accagcccct gcacttggtt    180

ccttgcgttg cctctggctg gaagctgttg tccccaactt cagaaagtgt ctgcagattt    240

cacaggctct ctcttgggtc aaggattgat caaataaata tatcacggat aatgggagct    300

ggattcctca ctgcctgaga aaagaacaca aatagagaaa gggagaaaga ataaaccctg    360

taatgctgaa acggaattaa agggaccagc tctgtgaaca cggcaagtaa caacagagag    420

aaaacgtgag gagaaaagag agaccgggat tttgaaatcc tgtttcctga atgccatctc    480

accaggcaca cgaaagaata aaattaagga atc                                 513


<210>  9054
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  9054

Glu Arg Leu Pro Ser Asn Gln Ser Pro Pro Gln Arg Lys Ser Ala Gln 
1               5                   10                  15      


Glu Thr Leu Leu Pro Pro Ala Pro Ala Leu Gly Ser Leu Arg Cys Leu 
            20                  25                  30          


Trp Leu Glu Ala Val Val Pro Asn Phe Arg Lys Cys Leu Gln Ile Ser 
        35                  40                  45              


Gln Ala Leu Ser Trp Val Lys Asp 
    50                  55      


<210>  9055
<211>  455
<212>  DNA
<213>  Homosapiens

<400>  9055
tctcactcct caggtcagca aaagtgtcaa tgataacccc aaaaatcagg ttaagaacaa     60

tgatgatgac catgaagaag aacaagaggt cataaataac tctagcagca aacaggggtt    120

cctggaaaag agaggtgtct ggatcagtct gggtcccttg cgaccctttg gtctgcggag    180

cctggggcac agctcaagtg agacctcatc tacttgggta gaaattaaat tgggcattca    240

acttttaaac tgaaaactgc atctcttttc atgtcccctg tctcaattgc gacttctcca    300

agtgtggtgt gacacagcca ggagggatat tcactggacc agctctgtga acacggcaag    360

taacaacaga gagaaaacgt gaggagaaaa gagagaccgg gattttgaaa tcctgtttcc    420

tgaatgccat ctcaccaggc acacgaaaga ataaa                               455


<210>  9056
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  9056

Lys Leu His Leu Phe Ser Cys Pro Leu Ser Gln Leu Arg Leu Leu Gln 
1               5                   10                  15      


Val Trp Cys Asp Thr Ala Arg Arg Asp Ile His Trp Thr Ser Ser Val 
            20                  25                  30          


Asn Thr Ala Ser Asn Asn Arg Glu Lys Thr 
        35                  40          


<210>  9057
<211>  224
<212>  DNA
<213>  Homosapiens

<400>  9057
ttcaacagtg tcagcggagg ctcacgaggc atggtgactg aagccccgca ggaggtggga     60

tttgcaaagg acattattgg aatgaagggt gaaatttgaa taagggacca gctctgtgaa    120

cacggcaagt aacaacagag agaaaacgtg aggagaaaag agagaccggg attttgaaat    180

cctgtttcct gaatgccatc tcaccaggca cacgaaagaa taaa                     224


<210>  9058
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  9058

Thr Arg Gln Val Thr Thr Glu Arg Lys Arg Glu Glu Lys Arg Glu Thr 
1               5                   10                  15      


Gly Ile Leu Lys Ser Cys Phe Leu Asn Ala Ile Ser Pro Gly Thr Arg 
            20                  25                  30          


Lys Asn 
        


<210>  9059
<211>  2132
<212>  DNA
<213>  Homosapiens

<400>  9059
ctctgttcag tagacttagg gactgtttcc atcagggtta ggcctgatcc acctgaacgc     60

acagtgaata tccctcctgg ctgtgtcaca ccacacttgg agaagtcgca attgagacag    120

gggacatgaa aagagatgca gttttcagtt taaaagttga atgcccaatt taatttctac    180

ccaagtagat gaggtctcac ttgagctgtg ccccaggctc cgcagaccaa agggtcgcaa    240

gggacccaga ctgatccaga cacctctctt ttccaggaac ccctgtttgc tgctagagtt    300

atttatgacc tcttgttctt cttcatggtc atcatcattg ttcttaacct gatttttggg    360

gttatcattg acacttttgc tgacctgagg agtgagaagc agaagaagga agagatcttg    420

aagaccacgt gctttatctg tggcttggaa agagacaagt ttgacaacaa gactgtcacc    480

tttgaagagc acatcaagga agaacacaac atgtggcact atctgtgctt catcgtcctg    540

gtgaaagtaa aggactccac cgaatatact gggcctgaga gttacgtggc agaaatgatc    600

aaggaaagaa accttgactg gttccccagg atgagagcca tgtcattggt cagcagtgat    660

tctgaaggag aacagaatga gctgagaaac ctgcaggaga agctggagtc caccatgaaa    720

cttgtcacga acctttctgg ccagctgtcg gaattaaagg atcagatgac agaacaaagg    780

aagcagaaac aaagaattgg tcttctagga catcctcctc acatgaatgt caacccacaa    840

caaccagcat aagcaaatga aagaaaggaa ttgtatttac cttttataat tattattagt    900

gtgggtatgg ctaatgagtt ctgattcacc cacgaaggtt acatttatgc tgaatacatt    960

tgtaaatact cagttttata ctgtatgtat atgattgcta ctctaaaggt ttggatatat   1020

gtattgtaat tagaattgtt ggcatgatga catttcattt gtgccaaaaa tattaaaaat   1080

gccttttttg gaaggactaa cagaaagcac ctgatttgca cttgaaccag attatagatt   1140

taaaagtata tgacatgtat tttgtattta aaactagaat agccagtatt tatgtttttt   1200

ataaaactgt gcaatacgaa ttatgcaatc acaatacatt tgtagctccc gagtgtccta   1260

aagggagtgc acttctttga agctggtgtg ttaatactat gtaataaatg gttaactttc   1320

aaatgatgct gctgccaaaa ttatattaat agtgagtttc aggcccctgg gcattttgta   1380

ccatgtaatt atcctctggt gatgctgttt ctcgttagtg gcagtagtgc ctccgtctcc   1440

tagtgataat gctccaagtc tatgaactgt taaatcagca ttcattttaa gaaaagcaac   1500

tttagtttca aagatacttt taagcttcta aattgatcat ttaaactatt tctttaaata   1560

agagagccaa attagaggct catactttag cttgtgaaga agataatgaa ttttttaaag   1620

ggaactttct atgcaatgtt caggataaat gcatactgct ggccaatcag tgtcatctcc   1680

tgggtaaatt ttgatgtcgc attataaaga catgcataat tgatggtttc tagattatct   1740

agtccaaaca atagagttta ttttttcttc atctgaacca acatgctaca gtagctaaga   1800

agtattaaaa ctatatacat ccatataaag atgaaatatg aactatctca ttagaagtca   1860

tagttgacca cagacatgtt attcttctga aagagccaca ttttggtttt atttcttgtc   1920

acatgatttc ttttcttgat ggatgaaaaa tatgaaagga aacttttata tctgttgcct   1980

agttttgtac atggatctca ttttacaaga gaatctctct gcaaaaaaaa aaaaaacagt   2040

ttaaaaatgc attgaaagca gagttctgaa atgagtaaag tttgtaaatg catatataaa   2100

aatatttaat aaatgatgca gaatatacag tg                                 2132


<210>  9060
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  9060

Met Val Ile Ile Ile Val Leu Asn Leu Ile Phe Gly Val Ile Ile Asp 
1               5                   10                  15      


Thr Phe Ala Asp Leu Arg Ser Glu Lys Gln Lys Lys Glu Glu Ile Leu 
            20                  25                  30          


Lys Thr Thr Cys Phe Ile Cys Gly Leu Glu Arg Asp Lys Phe Asp Asn 
        35                  40                  45              


Lys Thr Val Thr Phe Glu Glu His Ile Lys Glu Glu His Asn Met Trp 
    50                  55                  60                  


His Tyr Leu Cys Phe Ile Val Leu Val Lys Val Lys Asp Ser Thr Glu 
65                  70                  75                  80  


Tyr Thr Gly Pro Glu Ser Tyr Val Ala Glu Met Ile Lys Glu Arg Asn 
                85                  90                  95      


Leu Asp Trp Phe Pro Arg Met Arg Ala Met Ser Leu Val Ser Ser Asp 
            100                 105                 110         


Ser Glu Gly Glu Gln Asn Glu Leu Arg Asn Leu Gln Glu Lys Leu Glu 
        115                 120                 125             


Ser Thr Met Lys Leu Val Thr Asn Leu Ser Gly Gln Leu Ser Glu Leu 
    130                 135                 140                 


Lys Asp Gln Met Thr Glu Gln Arg Lys Gln Lys Gln Arg Ile Gly Leu 
145                 150                 155                 160 


Leu Gly His Pro Pro His Met Asn Val Asn Pro Gln Gln Pro Ala 
                165                 170                 175 


<210>  9061
<211>  3435
<212>  DNA
<213>  Homosapiens

<400>  9061
ctctgttcag tagacttagg gactgtttcc atcagggtta ggcctgatcc acctgaacgc     60

acagtgaata tccctcctgg ctgtgtcaca ccacacttgg agaagtcgca attgagacag    120

gggacatgaa aagagatgca gttttcagtt taaaagttga atgcccaatt taatttctac    180

ccaagtagat gaggtctcac ttgagctgtg ccccaggctc cgcagaccaa agggtcgcaa    240

gggacccaga ctgatccaga cacctctctt ttccaggaac ccctgtttgc tgctagagtt    300

atttatgacc tcttgttctt cttcatggtc atcatcattg ttcttaacct gatttttggg    360

gttatcattg acacttttgc tgacctgagg agtgagaagc agaagaagga agagatcttg    420

aagaccacgt gctttatctg tggcttggaa agagacaagt ttgacaacaa gactgtcacc    480

tttgaagagc acatcaagga agaacacaac atgtggcact atctgtgctt catcgtcctg    540

gtgaaagtaa aggactccac cgaatatact gggcctgaga gttacgtggc agaaatgatc    600

aaggaaagaa accttgactg gttccccagg atgagagcca tgtcattggt cagcagtgat    660

tctgaaggag aacagaatga gctgagaaac ctgcaggaga agctggagtc caccatgaaa    720

cttgtcacga acctttctgg ccagctgtcg gaattaaagg atcagatgac agaacaaagg    780

aagcagaaac aaagaattgg tcttctagga catcctcctc acatgaatgt caacccacaa    840

caaccagcat aagcaaatga aagaaaggaa ttgtatttac cttttataat tattattagt    900

gtgggtatgg ctaatgagtt ctgattcacc cacgaaggtt acatttatgc tgaatacatt    960

tgtaaatact cagttttata ctgtatgtat atgattgcta ctctaaaggt ttggatatat   1020

gtattgtaat tagaattgtt ggcatgatga catttcattt gtgccaaaaa tattaaaaat   1080

gccttttttg gaaggactaa cagaaagcac ctgatttgca cttgaaccag attatagatt   1140

taaaagtata tgacatgtat tttgtattta aaactagaat agccagtatt tatgtttttt   1200

ataaaactgt gcaatacgaa ttatgcaatc acaatacatt tgtagctccc gagtgtccta   1260

aagggagtgc acttctttga agctggtgtg ttaatactat gtaataaatg gttaactttc   1320

aaatgatgct gctgccaaaa ttatattaat agtgagtttc aggcccctgg gcattttgta   1380

ccatgtaatt atcctctggt gatgctgttt ctcgttagtg gcagtagtgc ctccgtctcc   1440

tagtgataat gctccaagtc tatgaactgt taaatcagca ttcattttaa gaaaagcaac   1500

tttagtttca aagatacttt taagcttcta aattgatcat ttaaactatt tctttaaata   1560

agagagccaa attagaggct catactttag cttgtgaaga agataatgaa ttttttaaag   1620

ggaactttct atgcaatgtt caggataaat gcatactgct ggccaatcag tgtcatctcc   1680

tgggtaaatt ttgatgtcgc attataaaga catgcataat tgatggtttc tagattatct   1740

agtccaaaca atagagttta ttttttcttc atctgaacca acatgctaca gtagctaaga   1800

agtattaaaa ctatatacat ccatataaag atgaaatatg aactatctca ttagaagtca   1860

tagttgacca cagacatgtt attcttctga aagagccaca ttttggtttt atttcttgtc   1920

acatgatttc ttttcttgat ggatgaaaaa tatgaaagga aacttttata tctgttgcct   1980

agttttgtac atggatctca ttttacaaga gaatctctct gcaaaaaaaa aaaaaacagt   2040

ttaaaaatgc attgaaagca gagttctgaa atgagtaaag tttgtaaatg catatataaa   2100

aatatttaat aaatgatgca gaatatacag tgactggttg gtggctttca tttggcattt   2160

gtgacttaac tgctattcca tttatgtact ttctttagga tcagtttgaa gtacagtcgg   2220

tttgattacc aggttaattc agaaaatgtt tacctgatta tttaaaaaaa cacttgctgt   2280

tgttatgaca gctctgagga gaattattag aacaaacatt ggggagtatt tagtacaaca   2340

ttcattcatt cttctggatt agtgactgcc agccaggctg tcgggagcgc cctactaaat   2400

ctcctgtctc ttctgctttt actgggggat ctttaatttg ctgtgtgcca tgtggaagta   2460

tcgggaacag ctgaaatttg ttttagttca tgcccagtgg tcagggtcct tcagcaaagt   2520

gtaaaatgtt tttacagagc caccttgcct gtccaaacgt agtaaaacct gttccctcct   2580

caaatcagtg cttgccctgg ctgctttttt tgacactaat tttctctatg ctttggtaaa   2640

taataccacc caatgttggg aactaggtca agattaaatt ccagttaaat ggctagtttt   2700

gtaactaatg cttctacttt ataaatttga taacttaaaa acaaattaat tttttccagt   2760

cagtgcagcc tgtctccaca aaatttttcc atcgtaaggc aagcctaaga cagataccta   2820

cttttatctg taagcaaaat ggcaatctat gctaaccccc acaatgcaca cattagctag   2880

caaggacttg cttttcccct gggctttctc tttgatctct cacactgccc aacgagatgt   2940

ggcagtgtgt gtggtttgtc tcccaagtcc catccagttc attggaaagt tctgcattga   3000

catgccaagt tgcagctttt acaggtttgt catgttccat ttgaatcctg tcacttaaga   3060

tataaatctt cattcagtgt gccagcttca gcagaaaata aacgaaattg gaatgccact   3120

cctccctcca tgcagtagat cctacccttg ccgtttgggt gtgaacacta aagctagtag   3180

aattgaaaca tacaatttga agtgaaaact ccgggggcct ttgatgtgta attgtaattc   3240

tgcctgcttc cttcacattg tgcctttcca acacctctat tttaagatca aggtccaagt   3300

caccttcaaa gttacctacc cggatgaaga attagtgtta tcagggtgaa agtatggtag   3360

tactcgctaa catgagagaa agccaatgtt acttaattaa gccattttat ttaatattaa   3420

cagtttgcta cagca                                                    3435


<210>  9062
<211>  175
<212>  PRT
<213>  Homosapiens

<400>  9062

Met Val Ile Ile Ile Val Leu Asn Leu Ile Phe Gly Val Ile Ile Asp 
1               5                   10                  15      


Thr Phe Ala Asp Leu Arg Ser Glu Lys Gln Lys Lys Glu Glu Ile Leu 
            20                  25                  30          


Lys Thr Thr Cys Phe Ile Cys Gly Leu Glu Arg Asp Lys Phe Asp Asn 
        35                  40                  45              


Lys Thr Val Thr Phe Glu Glu His Ile Lys Glu Glu His Asn Met Trp 
    50                  55                  60                  


His Tyr Leu Cys Phe Ile Val Leu Val Lys Val Lys Asp Ser Thr Glu 
65                  70                  75                  80  


Tyr Thr Gly Pro Glu Ser Tyr Val Ala Glu Met Ile Lys Glu Arg Asn 
                85                  90                  95      


Leu Asp Trp Phe Pro Arg Met Arg Ala Met Ser Leu Val Ser Ser Asp 
            100                 105                 110         


Ser Glu Gly Glu Gln Asn Glu Leu Arg Asn Leu Gln Glu Lys Leu Glu 
        115                 120                 125             


Ser Thr Met Lys Leu Val Thr Asn Leu Ser Gly Gln Leu Ser Glu Leu 
    130                 135                 140                 


Lys Asp Gln Met Thr Glu Gln Arg Lys Gln Lys Gln Arg Ile Gly Leu 
145                 150                 155                 160 


Leu Gly His Pro Pro His Met Asn Val Asn Pro Gln Gln Pro Ala 
                165                 170                 175 


<210>  9063
<211>  599
<212>  DNA
<213>  Homosapiens

<400>  9063
ccttgcagac gaaagctgct gacgggaaaa ccacgcggga ggggaacgtc taggccctgg     60

ccctttcccc tcaaaggccg cgggaacata gggctgggga atcctggcag aggctctggg    120

cattattaca gatggtcgtt gagggtcgca agcaccaggc ctggaggccc tcctcggcct    180

gctaccagct gtgacctttg gaaagtgact tggctcgcgc ctcagttttc cgttttctgg    240

aggacttgcg gcctgagagt ggccaaaaag aagagagtta ctgtcgcagt cactgcctgc    300

ctagtgggta tttaggtgcc cagtcatgcc tttgctctcg gagccagtgc ctggtgcaag    360

cactgcggtg ggttcgtgcc ccagcttggg ggccacaggg ctgactcggc cgcactgcct    420

atgcgagctt ggccccagtt tcctcgtcag ggcacagaac ttccttcaaa gtgcaatact    480

tccattgtgt tcagtgcaat accttgcgtc acaccatggg acccatgcaa tgctggaagt    540

gctcccaaga agcagagaaa agtcatgaca ttagaagaaa aagttgaatt gcttgatat     599


<210>  9064
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  9064

Met Pro Leu Leu Ser Glu Pro Val Pro Gly Ala Ser Thr Ala Val Gly 
1               5                   10                  15      


Ser Cys Pro Ser Leu Gly Ala Thr Gly Leu Thr Arg Pro His Cys Leu 
            20                  25                  30          


Cys Glu Leu Gly Pro Ser Phe Leu Val Arg Ala Gln Asn Phe Leu Gln 
        35                  40                  45              


Ser Ala Ile Leu Pro Leu Cys Ser Val Gln Tyr Leu Ala Ser His His 
    50                  55                  60                  


Gly Thr His Ala Met Leu Glu Val Leu Pro Arg Ser Arg Glu Lys Ser 
65                  70                  75                  80  


<210>  9065
<211>  2350
<212>  DNA
<213>  Homosapiens

<400>  9065
ctgcaggaag agagaccagg aagggtcgtg actgcttgcg cacggctgca ggcgttctgc     60

cgggcaagaa cctcccggtg cgcccggagc tgctccaagt tgagagtggc gcataacatg    120

gggctgcagt tgaggcttga agggccaagg agtgccaact taccctgatt tctttgcaag    180

tttcattaag ctcttcagca tctgagaaag gattagaatg tttattcaca ctctccaaat    240

tccagtttat cagttcattg attcatcaac gttgattaag cacttactat gtgctgagaa    300

tacaaagggt tgcagaaaag gaagaagaat cagcagagag catttgtggc cagcaaagct    360

taaaatattt cctaaccgat cctttgcaaa aaaagttcac ccactcctgt agtcagcagc    420

tcccctactg tgcgcagtca gtgtgccatc tcagactagc aaagatttgt gcttggatca    480

tctacacttc cctgaatgtt gaagaagata tgctatccat gcaatccttg tcgactgctt    540

gattaaaaag tggataaacc tgtcttcagg cccttggagt atggtgtctg tgtgaagaag    600

ggaatgaggc agaagtagca gtcagtggtg gctgaagtag gagaaagtgc ttgctaatga    660

aatcttgatt tttctgtggc ttttctgtgc aattgggtgg ctaagtagga aagccattgg    720

agcttcactg tatcaattct gcctttcttg ttttttggaa ctccaattca ccaaggctcc    780

ctgccaccct atccatctat aacttttcat cactttttcc tcaaagtaag aagtgtgtcc    840

cagaaaatgt gcctttgtga ctcagcaaca tttcaaatcc atctgagcct tcccagcgtt    900

ccaaaagaaa tactgatttg aattcagctg cttaaaaaac cagtctctaa gcagacagct    960

tgaaacttcc ttacagcaat agtttaggct ttggagggga aattggtttg tttttaattg   1020

ttttaatttt tcattcaatt catttgccgc ctgattatat atgatctttt gagcccaata   1080

ctctgctaaa ttaaccttga ctttctttct ctctttctct ctctctcctt ctctctttct   1140

tcctttcttt ctttcttttt gacagagcct tgctctgtcg cccaggctgg aatgcagtgg   1200

cacaatctca gctcactgta aactccgcct ccaaagttca agcaattctc ctgcctcagc   1260

ctcctgtgta gctgggatta cacacgccag ccaccatgcc tggctaattt ttgtattttt   1320

agtaaagatg gagtttcacc ctcttggcca agctggtctc gaactcctga cctcaacctt   1380

ggcctctcaa agtgctggga ttacaagcat gagccaccat gcctggcctt accttgattt   1440

tttttttttg agacagagtc tcactctgtt gctcaggctg gagtgtagtg gctcgatctt   1500

ggctcactgc aacctccatc tcccgggttc aagagattct cctgcctcag cctcccaagt   1560

agctgggact acaggtgtgg gccaccacgc ctagctaatt ttttatatgt ttactagaga   1620

cagggtttca ccatgttggg caggctggtc ttgaactcct gacctcaggt gattcacctg   1680

cctcggcctc ccaaaatgct gggattacag gtgtgagcca ccacacccgg cccctacctt   1740

tgatttttaa gtcaagaggg aacaagtcga aatttctatt caggtaaact gtataccttt   1800

ggacactgaa tcacttttag aaccccagta aaaatcatgt atgaatgacc cacaatttca   1860

ctccaacagg aaggtgtgta tatgtgcaca aaaacattag attgttcaca ccggtgctat   1920

tcataatagt caaaaactgg aaacaactca aacatccatc aactgtagaa tggataaata   1980

aatcatgata tattcatacc atggaacata acagtgacaa taaatgaacc actgctacac   2040

acaacagata tgaatttcac aaacagaatg ctgagcaaca gaagccaaac acagaaggat   2100

acacatttat aaatccattt gtatgaagtt cataaacaga caaaattagt cagtggagat   2160

tattctcata gaagtctgaa gggtagttgt ctttagggag ggggatatag tgactgaggt   2220

gggtataagg ggtttctggg gtttggtgat ggtacaccag catattcact ctgaaaactc   2280

attgagctgt gcaataatga tttttcaaac ttttatatgt gtatgataat gcttcaataa   2340

agctttgctt                                                          2350


<210>  9066
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  9066

Met Phe Ile His Thr Leu Gln Ile Pro Val Tyr Gln Phe Ile Asp Ser 
1               5                   10                  15      


Ser Thr Leu Ile Lys His Leu Leu Cys Ala Glu Asn Thr Lys Gly Cys 
            20                  25                  30          


Arg Lys Gly Arg Arg Ile Ser Arg Glu His Leu Trp Pro Ala Lys Leu 
        35                  40                  45              


Lys Ile Phe Pro Asn Arg Ser Phe Ala Lys Lys Val His Pro Leu Leu 
    50                  55                  60                  


<210>  9067
<211>  544
<212>  DNA
<213>  Homosapiens

<400>  9067
catctgtcat ccatctagtg aggtcaggag agtggctgct taacttctgg gggttgcaga     60

aaaggaagaa gaatcagcag agagcatttg tggccagcaa agcttaaaat atttcctaac    120

cgatcctttg caaaaaaagt tcacccactc ctgtagtcag cagctcccct actgtgcgca    180

gtcagtgtgc catctcagac tagcaaagtt gtccagagag gaaagacagg ccaaaatagt    240

tcagtatgct gtcttactgg gaggacaaca gcttaagcca caaagccctg agtttgaccc    300

tagaactctg tggctactgg tgactcatct tgaaaattat cagattgaat cttctctacc    360

ggtttgataa caactgatga gtggaaaaag aacgccaatc aaatgtgcat gcttaataag    420

cagcctcctt attcccctct gcagatttgt gcttggatca tctacacttc cctgaatgtt    480

gaagaagata tgctatccat gcaatccttg tcgactgctt gattaaaaag tggataaacc    540

tgtc                                                                 544


<210>  9068
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  9068

Met Cys Met Leu Asn Lys Gln Pro Pro Tyr Ser Pro Leu Gln Ile Cys 
1               5                   10                  15      


Ala Trp Ile Ile Tyr Thr Ser Leu Asn Val Glu Glu Asp Met Leu Ser 
            20                  25                  30          


Met Gln Ser Leu Ser Thr Ala 
        35                  


<210>  9069
<211>  2987
<212>  DNA
<213>  Homosapiens

<400>  9069
gtgggtgccg acggcggcgc cgggacgggc gtggggggta gggcgagtca tatgatccgc     60

tcggcttcct gggtctggct gctgccgccc gccggtgtcc gcccgtgtcg cgccggggca    120

ccaaggagcc gttggagggt ccgggcggag gcccgctcgt gtggaagtcg tcgacgccgc    180

cgctcgtccg tcctcccgtc cgttctcgct cccggccgcc atcatgctgg cgctcatctc    240

ccgcctgctg gactggttcc gttcgctctt ctggaaggaa gagatggagc tgacgctcgt    300

ggggctgcag tactcgggca agaccacctt cgtcaatgtc atcgcgtcag gtcaattcag    360

tgaagatatg atacccacag tgggcttcaa catgaggaag gtaactaaag gtaacgtcac    420

aataaagatc tgggacatag gaggacaacc ccgatttcga agcatgtggg agcggtattg    480

cagaggagtc aatgctattg tttacatgat agatgctgca gatcgtgaaa agatagaagc    540

ttcccgaaat gagctacata atcttctaga taaaccacag ttacaaggaa ttccagtgct    600

agtgcttgga aacaagagag atcttcctaa tgccttggat gagaaacagc taattgaaaa    660

aatgaatctg tctgctattc aggatagaga aatttgctgc tattcaattt cttgcaaaga    720

aaaggataat atagatatca cacttcagtg gcttattcag cattcaaaat ctagaagaag    780

ctgaagcatc tcctgaagtc ttccagtcct tcttggctat aatcctagaa ttattgtccg    840

ttcctctgaa gtaattccca gaatacggtc cttcctaaac cccagaaatt gcctttttca    900

gagtttattt ctcatgtgca ctgctgaaga tgaatatccc taatccttca taaagaatca    960

gctagagttg tcatgataaa gtcagcacac acaaaaaggc ttcttacaca tacctgtctt   1020

aaaccatgtg tagagcttta aaaacagaaa aaaaacccca tatacttatg accatcttaa   1080

atcaagaaaa ttgcatattt ccattctggt ctttctgggc cagattttta tattggtttt   1140

cagtaaatgt ctatctataa tatttcatta tagagtccag tagcttaata ctgacactga   1200

cttgatacag catgaagttt ctagtgccac acacagtatt tagaaaacct ttaggcgtga   1260

atgactcatg tgggatatat gtaaacataa tgtttatttt atctcacaaa tgcatgtgaa   1320

atgtataatt acatcttagg aatccaaaat ggtctgcaga gagtgagcgg aggcaccaga   1380

tcaatgttgg ttctttgcac tggtgagatt ctgcctgatg aatattaaag atatcctgct   1440

ttctgagaac tctatcacca gatggcagtt gggatatggg aggaactaaa gcatcctgtt   1500

ttgtatctgt ccagatcatt atttctgtct cttgtttttt cttcctggtt caggatactt   1560

ttttaagggg ttgagaattg aagattttcc aaaagcgttc atgaatttag agcattccac   1620

ccaatataat aaaacctgtt aagaatgtca gtctttgttc aaacatctgt ttgttctatc   1680

tccagtcatt aaatcagtgc tgctgcatga cactcttaac tcctgacttt ttatatccag   1740

tcataaagtt gactttcagc acaaaagata cttataaaca aataaaaaat ttttattttt   1800

ctctcttact gatgtaagct ttggcactct tttgactggt gccattagac atcttgatta   1860

ttgtgacaac tctagacctg cctgctttat ctaatgtaat catgctcaat gtctacaggt   1920

tgtttaataa tcagtcacac agagaactga ggaactgatg ctgtttgttt gcttctatga   1980

tacagagatg tctaaaaact tcaaatggac atgttttgta gtttagcgac ttccgtatac   2040

ataaagggac atattaatac tggttcattt gtaaattatt attcatatag accactgtag   2100

tagataaaac tctatggtac acctgcttat gtgttgcctc acactgtgtg tgattttgtt   2160

tcttttgtta agcagcactt atgtagactg catttccaaa tgtgttgagc actcagagtg   2220

tagtcaacag taagttcttt taatgaatat cagttttaat ttatagactg ccatggcctt   2280

aaaaatattc tgtacaatat actgcactgt gttgcacaga cactacttgc ttttctccat   2340

tcatattttt atgagtagaa tctgggcttt taaatttctc ttcttattct ttgaagcatg   2400

ttgcatacta ccctggtggg atggatggtt ctgtaaatga agggatattt aaacttgcta   2460

ctgttgttca acaccattaa tggtcagtgt gaaccattac aaagaatgtg gcaacttgct   2520

tgtgcctaaa aggaggaatt ggaactagaa tgtgtgactc tgtggggact gcataggttt   2580

gttaattgac ctatagctaa accttaatgt gtttgtgtgt ctatacattg ctttccgcat   2640

ttcaagacat ccagacgcta ttaccaacat tttcctgtgc attaacctct gcatgtgaaa   2700

acttttaaca gttactgaac tatgtaaata tgtgaatttt tttatttagg tggatgcatt   2760

ttttgtctgt ttactgctct tctcagcttt attcaataaa cttgcatttt aagggttgta   2820

ttggcaattt taacttaaaa tgtgcatcat gatggaaggt gcagactttt ttggaagttt   2880

ccgagaggag ggtctataga ccatttgtca gaaatcagat cagccctcaa agaatggggt   2940

ctgtgggcta gttaaaatag aaataaactt ttaaaatatc cacagaa                 2987


<210>  9070
<211>  186
<212>  PRT
<213>  Homosapiens

<400>  9070

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Val Leu Val Leu 
        115                 120                 125             


Gly Asn Lys Arg Asp Leu Pro Asn Ala Leu Asp Glu Lys Gln Leu Ile 
    130                 135                 140                 


Glu Lys Met Asn Leu Ser Ala Ile Gln Asp Arg Glu Ile Cys Cys Tyr 
145                 150                 155                 160 


Ser Ile Ser Cys Lys Glu Lys Asp Asn Ile Asp Ile Thr Leu Gln Trp 
                165                 170                 175     


Leu Ile Gln His Ser Lys Ser Arg Arg Ser 
            180                 185     


<210>  9071
<211>  1647
<212>  DNA
<213>  Homosapiens

<400>  9071
gggtgccgac ggcggcgccg ggacgggcgt ggggggtagg gcgagtcata tgatccgctc     60

ggcttcctgg gtctggctgc tgccgcccgc cggtgtccgc ccgtgtcgcg ccggggcacc    120

aaggagccgt tggagggtcc gggcggaggc ccgctcgtgt ggaagtcgtc gacgccgccg    180

ctcgtccgtc ctcccgtccg ttctcgctcc cggccgccat catgctggcg ctcatctccc    240

gcctgctgga ctggttccgt tcgctcttct ggaaggaaga gatggagctg acgctcgtgg    300

ggctgcagta ctcgggcaag accaccttcg tcaatgtcat cgcgtcaggt caattcagtg    360

aagatatgat acccacagtg ggcttcaaca tgaggaaggt aactaaaggt aacgtcacaa    420

taaagatctg ggacatagga ggacaacccc gatttcgaag catgtgggag cggtattgca    480

gaggagtcaa tgctattgtt tacatgatag atgctgcaga tcgtgaaaag atagaagctt    540

cccgaaatga gctacataat cttctagata aaccacagtt acaaggaatt ccagtgctag    600

tgcttggaaa caagagagat cttcctaatg ccttggatga gaaacagcta attgaaaaaa    660

tgaatctgtc tgctattcag gatagagaaa tttgctgcta ttcaatttct tgcaaagaaa    720

aggataatat agatatcaca cttcagtggc ttattcagca ttcaaaatct agaagaagct    780

gaagcatctc ctgaagtctt ccagtccttc ttggctataa tcctagaatt attgtccgtt    840

cctctgaagt aattcccaga atacggtcct tcctaaaccc cagaaattgc ctttttcaga    900

gtttatttct catgtgcact gctgaagatg aatatcccta atccttcata aagaatcagc    960

tagagttgtc atgataaagt cagcacacac aaaaaggctt cttacacata cctgtcttaa   1020

accatgtgta gagctttaaa aacagaaaaa aaaccccata tacttatgac catcttaaat   1080

caagaaaatt gcatatttcc attctggtct ttctgggcca gatttttata ttggttttca   1140

gtaaatgtct atctataata tttcattata gagtccagta gcttaatact gacactgact   1200

tgatacagca tgaagtttct agtgccacac acagtattta gaaaaccttt aggcgtgaat   1260

gactcatgtg ggatatatgt aaacataatg tttattttat ctcacaaatg catgtgaaat   1320

gtataattac atcttaggaa tccaaaatgg tctgcagaga gtgagcggag gcaccagatc   1380

aatgttggtt ctttgcactg gtgagattct gcctgatgaa tattaaagat atcctgcttt   1440

ctgagaactc tatcaccaga tggcagttgg gatatgggag gaactaaagc atcctgtttt   1500

gtatctgtcc agatcattat ttctgtctct tgttttttct tcctggttca ggatactttt   1560

ttaaggggtt gagaattgaa gattttccaa aagcgttcat gaatttagag cattccaccc   1620

aatataataa aacctgttaa gaatgtc                                       1647


<210>  9072
<211>  186
<212>  PRT
<213>  Homosapiens

<400>  9072

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Val Leu Val Leu 
        115                 120                 125             


Gly Asn Lys Arg Asp Leu Pro Asn Ala Leu Asp Glu Lys Gln Leu Ile 
    130                 135                 140                 


Glu Lys Met Asn Leu Ser Ala Ile Gln Asp Arg Glu Ile Cys Cys Tyr 
145                 150                 155                 160 


Ser Ile Ser Cys Lys Glu Lys Asp Asn Ile Asp Ile Thr Leu Gln Trp 
                165                 170                 175     


Leu Ile Gln His Ser Lys Ser Arg Arg Ser 
            180                 185     


<210>  9073
<211>  2817
<212>  DNA
<213>  Homosapiens

<400>  9073
gggtgccgac ggcggcgccg ggacgggcgt ggggggtagg gcgagtcata tgatccgctc     60

ggcttcctgg gtctggctgc tgccgcccgc cggtgtccgc ccgtgtcgcg ccggggcacc    120

aaggagccgt tggagggtcc gggcggaggc ccgctcgtgt ggaagtcgtc gacgccgccg    180

ctcgtccgtc ctcccgtccg ttctcgctcc cggccgccat catgctggcg ctcatctccc    240

gcctgctgga ctggttccgt tcgctcttct ggaaggaaga gatggagctg acgctcgtgg    300

ggctgcagta ctcgggcaag accaccttcg tcaatgtcat cgcgtcaggt caattcagtg    360

aagatatgat acccacagtg ggcttcaaca tgaggaaggt aactaaaggt aacgtcacaa    420

taaagatctg ggacatagga ggacaacccc gatttcgaag catgtgggag cggtattgca    480

gaggagtcaa tgctattgtt tacatgatag atgctgcaga tcgtgaaaag atagaagctt    540

cccgaaatga gctacataat cttctagata aaccacagtt acaaggaatt ccagtgctag    600

tgcttggaaa caagagagat cttcctaatg ccttggatga gaaacagcta attgaaaaaa    660

tgaatctgtc tgctattcag gatagagaaa tttgctgcta ttcaatttct tgcaaagaaa    720

aggataatat agatatcaca cttcagtggc ttattcagca ttcaaaatct agaagaagct    780

gaagcatctc ctgaagtctt ccagtccttc ttggctataa tcctagaatt attgtccgtt    840

cctctgaagt aattcccaga atacggtcct tcctaaaccc cagaaattgc ctttttcaga    900

gtttatttct catgtgcact gctgaagatg aatatcccta atccttcata aagaatcagc    960

tagagttgtc atgataaagt cagcacacac aaaaaggctt cttacacata cctgtcttaa   1020

accatgtgta gagctttaaa aacagaaaaa aaaccccata tacttatgac catcttaaat   1080

caagaaaatt gcatatttcc attctggtct ttctgggcca gatttttata ttggttttca   1140

gtaaatgtct atctataata tttcattata gagtccagta gcttaatact gacactgact   1200

tgatacagca tgaagtttct agtgccacac acagtattta gaaaaccttt aggcgtgaat   1260

gactcatgtg ggatatatgt aaacataatg tttattttat ctcacaaatg catgtgaaat   1320

gtataattac atcttaggaa tccaaaatgg tctgcagaga gtgagcggag gcaccagatc   1380

aatgttggtt ctttgcactg gtgagattct gcctgatgaa tattaaagat atcctgcttt   1440

ctgagaactc tatcaccaga tggcagttgg gatatgggag gaactaaagc atcctgtttt   1500

gtatctgtcc agatcattat ttctgtctct tgttttttct tcctggttca ggatactttt   1560

ttaaggggtt gagaattgaa gattttccaa aagcgttcat gaatttagag cattccaccc   1620

aatataataa aacctgttaa gaatgtcagt ctttgttcaa acatctgttt gttctatctc   1680

cagtcattaa atcagtgctg ctgcatgaca ctcttaactc ctgacttttt atatccagtc   1740

ataaagttga ctttcagcac aaaagatact tataaacaaa taaaaaattt ttatttttct   1800

ctcttactga tgtaagcttt ggcactcttt tgactggtgc cattagacat cttgattatt   1860

gtgacaactc tagacctgcc tgctttatct aatgtaatca tgctcaatgt ctacaggttg   1920

tttaataatc agtcacacag agaactgagg aactgatgct gtttgtttgc ttctatgata   1980

cagagatgtc taaaaacttc aaatggacat gttttgtagt ttagcgactt ccgtatacat   2040

aaagggacat attaatactg gttcatttgt aaattattat tcatatagac cactgtagta   2100

gataaaactc tatggtacac ctgcttatgt gttgcctcac actgtgtgtg attttgtttc   2160

ttttgttaag cagcacttat gtagactgca tttccaaatg tgttgagcac tcagagtgta   2220

gtcaacagta agttctttta atgaatatca gttttaattt atagactgcc atggccttaa   2280

aaatattctg tacaatatac tgcactgtgt tgcacagaca ctacttgctt ttctccattc   2340

atatttttat gagtagaatc tgggctttta aatttctctt cttattcttt gaagcatgtt   2400

gcatactacc ctggtgggat ggatggttct gtaaatgaag ggatatttaa acttgctact   2460

gttgttcaac accattaatg gtcagtgtga accattacaa agaatgtggc aacttgcttg   2520

tgcctaaaag gaggaattgg aactagaatg tgtgactctg tggggactgc ataggtttgt   2580

taattgacct atagctaaac cttaatgtgt ttgtgtgtct atacattgct ttccgcattt   2640

caagacatcc agacgctatt accaacattt tcctgtgcat taacctctgc atgtgaaaac   2700

ttttaacagt tactgaacta tgtaaatatg tgaatttttt tatttaggtg gatgcatttt   2760

ttgtctgttt actgctcttc tcagctttat tcaataaact tgcattttaa gggttgt      2817


<210>  9074
<211>  186
<212>  PRT
<213>  Homosapiens

<400>  9074

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Val Leu Val Leu 
        115                 120                 125             


Gly Asn Lys Arg Asp Leu Pro Asn Ala Leu Asp Glu Lys Gln Leu Ile 
    130                 135                 140                 


Glu Lys Met Asn Leu Ser Ala Ile Gln Asp Arg Glu Ile Cys Cys Tyr 
145                 150                 155                 160 


Ser Ile Ser Cys Lys Glu Lys Asp Asn Ile Asp Ile Thr Leu Gln Trp 
                165                 170                 175     


Leu Ile Gln His Ser Lys Ser Arg Arg Ser 
            180                 185     


<210>  9075
<211>  698
<212>  DNA
<213>  Homosapiens

<400>  9075
atatgatccg ctcggcttcc tgggtctggc tgctgccgcc cgccggtgtc cgcccgtgtc     60

gcgccggggc accaaggagc cgttggaggg tccgggcgga ggcccgctcg tgtggaagtc    120

gtcgacgccg ccgctcgtcc gtcctcccgt ccgttctcgc tcccggccgc catcatgctg    180

gcgctcatct cccgcctgct ggactggttc cgttcgctct tctggaagga agagatggag    240

ctgacgctcg tggggctgca gtactcgggc aagaccacct tcgtcaatgt catcgcgtca    300

ggtcaattca gtgaagatat gatacccaca gtgggcttca acatgaggaa ggtaactaaa    360

ggtaacgtca caataaaggt aagttatttc ttgccgtacg caatttaaat tgttagcaca    420

gacccctaga aatttttctg ttaaatttct gtgtttttac tgaaaatttg cagtttttca    480

gtaatgaatg tgcatgtttc aaaagaatag gtttttttgt tgttgttttt ttgttttttt    540

tttggaaaca gagttttgct ctttcaccca ggctggagtg cagtgtcgcg atctccactc    600

actgcaacct ctacctcccg gttcaagtga ttctcctgcc tcagcctcca aaatagctaa    660

gatgacaggc ttgtgccacc acacccagct aatttttt                            698


<210>  9076
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  9076

Met Ile Arg Ser Ala Ser Trp Val Trp Leu Leu Pro Pro Ala Gly Val 
1               5                   10                  15      


Arg Pro Cys Arg Ala Gly Ala Pro Arg Ser Arg Trp Arg Val Arg Ala 
            20                  25                  30          


Glu Ala Arg Ser Cys Gly Ser Arg Arg Arg Arg Arg Ser Ser Val Leu 
        35                  40                  45              


Pro Ser Val Leu Ala Pro Gly Arg His His Ala Gly Ala His Leu Pro 
    50                  55                  60                  


Pro Ala Gly Leu Val Pro Phe Ala Leu Leu Glu Gly Arg Asp Gly Ala 
65                  70                  75                  80  


Asp Ala Arg Gly Ala Ala Val Leu Gly Gln Asp His Leu Arg Gln Cys 
                85                  90                  95      


His Arg Val Arg Ser Ile Gln 
            100             


<210>  9077
<211>  1448
<212>  DNA
<213>  Homosapiens

<400>  9077
ggcttcctgg gtctggctgc tgccgcccgc cggtgtccgc ccgtgtcgcg ccggggcacc     60

aaggagccgt tggagggtcc gggcggaggc ccgctcgtgt ggaagtcgtc gacgccgccg    120

ctcgtccgtc ctcccgtccg ttctcgctcc cggccgccat catgctggcg ctcatctccc    180

gcctgctgga ctggttccgt tcgctcttct ggaaggaaga gatggagctg acgctcgtgg    240

ggctgcagta ctcgggcaag accaccttcg tcaatgtcat cgcgtcaggt caattcagtg    300

aagatatgat acccacagtg ggcttcaaca tgaggaaggt aactaaaggt aacgtcacaa    360

taaagatctg ggacatagga ggacaacccc gatttcgaag catgtgggag cggtattgca    420

gaggagtcaa tgctattgtt tacatgatag atgctgcaga tcgtgaaaag atagaagctt    480

cccgaaatga gctacataat cttctagata aaccacagtt acaaggaatt ccaatatcac    540

acttcagtgg cttattcagc attcaaaatc tagaagaagc tgaagcatct cctgaagtct    600

tccagtcctt cttggctata atcctagaat tattgtccgt tcctctgaag taattcccag    660

aatacggtcc ttcctaaacc ccagaaattg cctttttcag agtttatttc tcatgtgcac    720

tgctgaagat gaatatccct aatccttcat aaagaatcag ctagagttgt catgataaag    780

tcagcacaca caaaaaggct tcttacacat acctgtctta aaccatgtgt agagctttaa    840

aaacagaaaa aaaaccccat atacttatga ccatcttaaa tcaagaaaat tgcatatttc    900

cattctggtc tttctgggcc agatttttat attggttttc agtaaatgtc tatctataat    960

atttcattat agagtccagt agcttaatac tgacactgac ttgatacagc atgaagtttc   1020

tagtgccaca cacagtattt agaaaacctt taggcgtgaa tgactcatgt gggatatatg   1080

taaacataat gtttatttta tctcacaaat gcatgtgaaa tgtataatta catcttagga   1140

atccaaaatg gtctgcagag agtgagcgga ggcaccagat caatgttggt tctttgcact   1200

ggtgagattc tgcctgatga atattaaaga tatcctgctt tctgagaact ctatcaccag   1260

atggcagttg ggatatggga ggaactaaag catcctgttt tgtatctgtc cagatcatta   1320

tttctgtctc ttgttttttc ttcctggttc aggatacttt tttaaggggt tgagaattga   1380

agattttcca aaagcgttca tgaatttaga gcattccacc caatataata aaacctgtta   1440

agaatgtc                                                            1448


<210>  9078
<211>  163
<212>  PRT
<213>  Homosapiens

<400>  9078

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Ile Ser His Phe 
        115                 120                 125             


Ser Gly Leu Phe Ser Ile Gln Asn Leu Glu Glu Ala Glu Ala Ser Pro 
    130                 135                 140                 


Glu Val Phe Gln Ser Phe Leu Ala Ile Ile Leu Glu Leu Leu Ser Val 
145                 150                 155                 160 


Pro Leu Lys 
            


<210>  9079
<211>  2618
<212>  DNA
<213>  Homosapiens

<400>  9079
ggcttcctgg gtctggctgc tgccgcccgc cggtgtccgc ccgtgtcgcg ccggggcacc     60

aaggagccgt tggagggtcc gggcggaggc ccgctcgtgt ggaagtcgtc gacgccgccg    120

ctcgtccgtc ctcccgtccg ttctcgctcc cggccgccat catgctggcg ctcatctccc    180

gcctgctgga ctggttccgt tcgctcttct ggaaggaaga gatggagctg acgctcgtgg    240

ggctgcagta ctcgggcaag accaccttcg tcaatgtcat cgcgtcaggt caattcagtg    300

aagatatgat acccacagtg ggcttcaaca tgaggaaggt aactaaaggt aacgtcacaa    360

taaagatctg ggacatagga ggacaacccc gatttcgaag catgtgggag cggtattgca    420

gaggagtcaa tgctattgtt tacatgatag atgctgcaga tcgtgaaaag atagaagctt    480

cccgaaatga gctacataat cttctagata aaccacagtt acaaggaatt ccaatatcac    540

acttcagtgg cttattcagc attcaaaatc tagaagaagc tgaagcatct cctgaagtct    600

tccagtcctt cttggctata atcctagaat tattgtccgt tcctctgaag taattcccag    660

aatacggtcc ttcctaaacc ccagaaattg cctttttcag agtttatttc tcatgtgcac    720

tgctgaagat gaatatccct aatccttcat aaagaatcag ctagagttgt catgataaag    780

tcagcacaca caaaaaggct tcttacacat acctgtctta aaccatgtgt agagctttaa    840

aaacagaaaa aaaaccccat atacttatga ccatcttaaa tcaagaaaat tgcatatttc    900

cattctggtc tttctgggcc agatttttat attggttttc agtaaatgtc tatctataat    960

atttcattat agagtccagt agcttaatac tgacactgac ttgatacagc atgaagtttc   1020

tagtgccaca cacagtattt agaaaacctt taggcgtgaa tgactcatgt gggatatatg   1080

taaacataat gtttatttta tctcacaaat gcatgtgaaa tgtataatta catcttagga   1140

atccaaaatg gtctgcagag agtgagcgga ggcaccagat caatgttggt tctttgcact   1200

ggtgagattc tgcctgatga atattaaaga tatcctgctt tctgagaact ctatcaccag   1260

atggcagttg ggatatggga ggaactaaag catcctgttt tgtatctgtc cagatcatta   1320

tttctgtctc ttgttttttc ttcctggttc aggatacttt tttaaggggt tgagaattga   1380

agattttcca aaagcgttca tgaatttaga gcattccacc caatataata aaacctgtta   1440

agaatgtcag tctttgttca aacatctgtt tgttctatct ccagtcatta aatcagtgct   1500

gctgcatgac actcttaact cctgactttt tatatccagt cataaagttg actttcagca   1560

caaaagatac ttataaacaa ataaaaaatt tttatttttc tctcttactg atgtaagctt   1620

tggcactctt ttgactggtg ccattagaca tcttgattat tgtgacaact ctagacctgc   1680

ctgctttatc taatgtaatc atgctcaatg tctacaggtt gtttaataat cagtcacaca   1740

gagaactgag gaactgatgc tgtttgtttg cttctatgat acagagatgt ctaaaaactt   1800

caaatggaca tgttttgtag tttagcgact tccgtataca taaagggaca tattaatact   1860

ggttcatttg taaattatta ttcatataga ccactgtagt agataaaact ctatggtaca   1920

cctgcttatg tgttgcctca cactgtgtgt gattttgttt cttttgttaa gcagcactta   1980

tgtagactgc atttccaaat gtgttgagca ctcagagtgt agtcaacagt aagttctttt   2040

aatgaatatc agttttaatt tatagactgc catggcctta aaaatattct gtacaatata   2100

ctgcactgtg ttgcacagac actacttgct tttctccatt catattttta tgagtagaat   2160

ctgggctttt aaatttctct tcttattctt tgaagcatgt tgcatactac cctggtggga   2220

tggatggttc tgtaaatgaa gggatattta aacttgctac tgttgttcaa caccattaat   2280

ggtcagtgtg aaccattaca aagaatgtgg caacttgctt gtgcctaaaa ggaggaattg   2340

gaactagaat gtgtgactct gtggggactg cataggtttg ttaattgacc tatagctaaa   2400

ccttaatgtg tttgtgtgtc tatacattgc tttccgcatt tcaagacatc cagacgctat   2460

taccaacatt ttcctgtgca ttaacctctg catgtgaaaa cttttaacag ttactgaact   2520

atgtaaatat gtgaattttt ttatttaggt ggatgcattt tttgtctgtt tactgctctt   2580

ctcagcttta ttcaataaac ttgcatttta agggttgt                           2618


<210>  9080
<211>  163
<212>  PRT
<213>  Homosapiens

<400>  9080

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Ile Ser His Phe 
        115                 120                 125             


Ser Gly Leu Phe Ser Ile Gln Asn Leu Glu Glu Ala Glu Ala Ser Pro 
    130                 135                 140                 


Glu Val Phe Gln Ser Phe Leu Ala Ile Ile Leu Glu Leu Leu Ser Val 
145                 150                 155                 160 


Pro Leu Lys 
            


<210>  9081
<211>  2786
<212>  DNA
<213>  Homosapiens

<400>  9081
ggcttcctgg gtctggctgc tgccgcccgc cggtgtccgc ccgtgtcgcg ccggggcacc     60

aaggagccgt tggagggtcc gggcggaggc ccgctcgtgt ggaagtcgtc gacgccgccg    120

ctcgtccgtc ctcccgtccg ttctcgctcc cggccgccat catgctggcg ctcatctccc    180

gcctgctgga ctggttccgt tcgctcttct ggaaggaaga gatggagctg acgctcgtgg    240

ggctgcagta ctcgggcaag accaccttcg tcaatgtcat cgcgtcaggt caattcagtg    300

aagatatgat acccacagtg ggcttcaaca tgaggaaggt aactaaaggt aacgtcacaa    360

taaagatctg ggacatagga ggacaacccc gatttcgaag catgtgggag cggtattgca    420

gaggagtcaa tgctattgtt tacatgatag atgctgcaga tcgtgaaaag atagaagctt    480

cccgaaatga gctacataat cttctagata aaccacagtt acaaggaatt ccaatatcac    540

acttcagtgg cttattcagc attcaaaatc tagaagaagc tgaagcatct cctgaagtct    600

tccagtcctt cttggctata atcctagaat tattgtccgt tcctctgaag taattcccag    660

aatacggtcc ttcctaaacc ccagaaattg cctttttcag agtttatttc tcatgtgcac    720

tgctgaagat gaatatccct aatccttcat aaagaatcag ctagagttgt catgataaag    780

tcagcacaca caaaaaggct tcttacacat acctgtctta aaccatgtgt agagctttaa    840

aaacagaaaa aaaaccccat atacttatga ccatcttaaa tcaagaaaat tgcatatttc    900

cattctggtc tttctgggcc agatttttat attggttttc agtaaatgtc tatctataat    960

atttcattat agagtccagt agcttaatac tgacactgac ttgatacagc atgaagtttc   1020

tagtgccaca cacagtattt agaaaacctt taggcgtgaa tgactcatgt gggatatatg   1080

taaacataat gtttatttta tctcacaaat gcatgtgaaa tgtataatta catcttagga   1140

atccaaaatg gtctgcagag agtgagcgga ggcaccagat caatgttggt tctttgcact   1200

ggtgagattc tgcctgatga atattaaaga tatcctgctt tctgagaact ctatcaccag   1260

atggcagttg ggatatggga ggaactaaag catcctgttt tgtatctgtc cagatcatta   1320

tttctgtctc ttgttttttc ttcctggttc aggatacttt tttaaggggt tgagaattga   1380

agattttcca aaagcgttca tgaatttaga gcattccacc caatataata aaacctgtta   1440

agaatgtcag tctttgttca aacatctgtt tgttctatct ccagtcatta aatcagtgct   1500

gctgcatgac actcttaact cctgactttt tatatccagt cataaagttg actttcagca   1560

caaaagatac ttataaacaa ataaaaaatt tttatttttc tctcttactg atgtaagctt   1620

tggcactctt ttgactggtg ccattagaca tcttgattat tgtgacaact ctagacctgc   1680

ctgctttatc taatgtaatc atgctcaatg tctacaggtt gtttaataat cagtcacaca   1740

gagaactgag gaactgatgc tgtttgtttg cttctatgat acagagatgt ctaaaaactt   1800

caaatggaca tgttttgtag tttagcgact tccgtataca taaagggaca tattaatact   1860

ggttcatttg taaattatta ttcatataga ccactgtagt agataaaact ctatggtaca   1920

cctgcttatg tgttgcctca cactgtgtgt gattttgttt cttttgttaa gcagcactta   1980

tgtagactgc atttccaaat gtgttgagca ctcagagtgt agtcaacagt aagttctttt   2040

aatgaatatc agttttaatt tatagactgc catggcctta aaaatattct gtacaatata   2100

ctgcactgtg ttgcacagac actacttgct tttctccatt catattttta tgagtagaat   2160

ctgggctttt aaatttctct tcttattctt tgaagcatgt tgcatactac cctggtggga   2220

tggatggttc tgtaaatgaa gggatattta aacttgctac tgttgttcaa caccattaat   2280

ggtcagtgtg aaccattaca aagaatgtgg caacttgctt gtgcctaaaa ggaggaattg   2340

gaactagaat gtgtgactct gtggggactg cataggtttg ttaattgacc tatagctaaa   2400

ccttaatgtg tttgtgtgtc tatacattgc tttccgcatt tcaagacatc cagacgctat   2460

taccaacatt ttcctgtgca ttaacctctg catgtgaaaa cttttaacag ttactgaact   2520

atgtaaatat gtgaattttt ttatttaggt ggatgcattt tttgtctgtt tactgctctt   2580

ctcagcttta ttcaataaac ttgcatttta agggttgtat tggcaatttt aacttaaaat   2640

gtgcatcatg atggaaggtg cagacttttt tggaagtttc cgagaggagg gtctatagac   2700

catttgtcag aaatcagatc agccctcaaa gaatggggtc tgtgggctag ttaaaataga   2760

aataaacttt taaaatatcc acagaa                                        2786


<210>  9082
<211>  163
<212>  PRT
<213>  Homosapiens

<400>  9082

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Trp Asp Ile Gly Gly Gln Pro Arg Phe Arg Ser 
65                  70                  75                  80  


Met Trp Glu Arg Tyr Cys Arg Gly Val Asn Ala Ile Val Tyr Met Ile 
                85                  90                  95      


Asp Ala Ala Asp Arg Glu Lys Ile Glu Ala Ser Arg Asn Glu Leu His 
            100                 105                 110         


Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Ile Ser His Phe 
        115                 120                 125             


Ser Gly Leu Phe Ser Ile Gln Asn Leu Glu Glu Ala Glu Ala Ser Pro 
    130                 135                 140                 


Glu Val Phe Gln Ser Phe Leu Ala Ile Ile Leu Glu Leu Leu Ser Val 
145                 150                 155                 160 


Pro Leu Lys 
            


<210>  9083
<211>  1374
<212>  DNA
<213>  Homosapiens

<400>  9083
tgccgcccgc cggtgtccgc ccgtgtcgcg ccggggcacc aaggagccgt tggagggtcc     60

gggcggaggc ccgctcgtgt ggaagtcgtc gacgccgccg ctcgtccgtc ctcccgtccg    120

ttctcgctcc cggccgccat catgctggcg ctcatctccc gcctgctgga ctggttccgt    180

tcgctcttct ggaaggaaga gatggagctg acgctcgtgg ggctgcagta ctcgggcaag    240

accaccttcg tcaatgtcat cgcgtcaggt caattcagtg aagatatgat acccacagtg    300

ggcttcaaca tgaggaaggt aactaaaggt aacgtcacaa taaagatctt cctaatgcct    360

tggatgagaa acagctaatt gaaaaaatga atctgtctgc tattcaggat agagaaattt    420

gctgctattc aatttcttgc aaagaaaagg ataatataga tatcacactt cagtggctta    480

ttcagcattc aaaatctaga agaagctgaa gcatctcctg aagtcttcca gtccttcttg    540

gctataatcc tagaattatt gtccgttcct ctgaagtaat tcccagaata cggtccttcc    600

taaaccccag aaattgcctt tttcagagtt tatttctcat gtgcactgct gaagatgaat    660

atccctaatc cttcataaag aatcagctag agttgtcatg ataaagtcag cacacacaaa    720

aaggcttctt acacatacct gtcttaaacc atgtgtagag ctttaaaaac agaaaaaaaa    780

ccccatatac ttatgaccat cttaaatcaa gaaaattgca tatttccatt ctggtctttc    840

tgggccagat ttttatattg gttttcagta aatgtctatc tataatattt cattatagag    900

tccagtagct taatactgac actgacttga tacagcatga agtttctagt gccacacaca    960

gtatttagaa aacctttagg cgtgaatgac tcatgtggga tatatgtaaa cataatgttt   1020

attttatctc acaaatgcat gtgaaatgta taattacatc ttaggaatcc aaaatggtct   1080

gcagagagtg agcggaggca ccagatcaat gttggttctt tgcactggtg agattctgcc   1140

tgatgaatat taaagatatc ctgctttctg agaactctat caccagatgg cagttgggat   1200

atgggaggaa ctaaagcatc ctgttttgta tctgtccaga tcattatttc tgtctcttgt   1260

tttttcttcc tggttcagga tactttttta aggggttgag aattgaagat tttccaaaag   1320

cgttcatgaa tttagagcat tccacccaat ataataaaac ctgttaagaa tgtc         1374


<210>  9084
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  9084

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Phe Leu Met Pro Trp Met Arg Asn Ser 
65                  70                  75              


<210>  9085
<211>  2544
<212>  DNA
<213>  Homosapiens

<400>  9085
tgccgcccgc cggtgtccgc ccgtgtcgcg ccggggcacc aaggagccgt tggagggtcc     60

gggcggaggc ccgctcgtgt ggaagtcgtc gacgccgccg ctcgtccgtc ctcccgtccg    120

ttctcgctcc cggccgccat catgctggcg ctcatctccc gcctgctgga ctggttccgt    180

tcgctcttct ggaaggaaga gatggagctg acgctcgtgg ggctgcagta ctcgggcaag    240

accaccttcg tcaatgtcat cgcgtcaggt caattcagtg aagatatgat acccacagtg    300

ggcttcaaca tgaggaaggt aactaaaggt aacgtcacaa taaagatctt cctaatgcct    360

tggatgagaa acagctaatt gaaaaaatga atctgtctgc tattcaggat agagaaattt    420

gctgctattc aatttcttgc aaagaaaagg ataatataga tatcacactt cagtggctta    480

ttcagcattc aaaatctaga agaagctgaa gcatctcctg aagtcttcca gtccttcttg    540

gctataatcc tagaattatt gtccgttcct ctgaagtaat tcccagaata cggtccttcc    600

taaaccccag aaattgcctt tttcagagtt tatttctcat gtgcactgct gaagatgaat    660

atccctaatc cttcataaag aatcagctag agttgtcatg ataaagtcag cacacacaaa    720

aaggcttctt acacatacct gtcttaaacc atgtgtagag ctttaaaaac agaaaaaaaa    780

ccccatatac ttatgaccat cttaaatcaa gaaaattgca tatttccatt ctggtctttc    840

tgggccagat ttttatattg gttttcagta aatgtctatc tataatattt cattatagag    900

tccagtagct taatactgac actgacttga tacagcatga agtttctagt gccacacaca    960

gtatttagaa aacctttagg cgtgaatgac tcatgtggga tatatgtaaa cataatgttt   1020

attttatctc acaaatgcat gtgaaatgta taattacatc ttaggaatcc aaaatggtct   1080

gcagagagtg agcggaggca ccagatcaat gttggttctt tgcactggtg agattctgcc   1140

tgatgaatat taaagatatc ctgctttctg agaactctat caccagatgg cagttgggat   1200

atgggaggaa ctaaagcatc ctgttttgta tctgtccaga tcattatttc tgtctcttgt   1260

tttttcttcc tggttcagga tactttttta aggggttgag aattgaagat tttccaaaag   1320

cgttcatgaa tttagagcat tccacccaat ataataaaac ctgttaagaa tgtcagtctt   1380

tgttcaaaca tctgtttgtt ctatctccag tcattaaatc agtgctgctg catgacactc   1440

ttaactcctg actttttata tccagtcata aagttgactt tcagcacaaa agatacttat   1500

aaacaaataa aaaattttta tttttctctc ttactgatgt aagctttggc actcttttga   1560

ctggtgccat tagacatctt gattattgtg acaactctag acctgcctgc tttatctaat   1620

gtaatcatgc tcaatgtcta caggttgttt aataatcagt cacacagaga actgaggaac   1680

tgatgctgtt tgtttgcttc tatgatacag agatgtctaa aaacttcaaa tggacatgtt   1740

ttgtagttta gcgacttccg tatacataaa gggacatatt aatactggtt catttgtaaa   1800

ttattattca tatagaccac tgtagtagat aaaactctat ggtacacctg cttatgtgtt   1860

gcctcacact gtgtgtgatt ttgtttcttt tgttaagcag cacttatgta gactgcattt   1920

ccaaatgtgt tgagcactca gagtgtagtc aacagtaagt tcttttaatg aatatcagtt   1980

ttaatttata gactgccatg gccttaaaaa tattctgtac aatatactgc actgtgttgc   2040

acagacacta cttgcttttc tccattcata tttttatgag tagaatctgg gcttttaaat   2100

ttctcttctt attctttgaa gcatgttgca tactaccctg gtgggatgga tggttctgta   2160

aatgaaggga tatttaaact tgctactgtt gttcaacacc attaatggtc agtgtgaacc   2220

attacaaaga atgtggcaac ttgcttgtgc ctaaaaggag gaattggaac tagaatgtgt   2280

gactctgtgg ggactgcata ggtttgttaa ttgacctata gctaaacctt aatgtgtttg   2340

tgtgtctata cattgctttc cgcatttcaa gacatccaga cgctattacc aacattttcc   2400

tgtgcattaa cctctgcatg tgaaaacttt taacagttac tgaactatgt aaatatgtga   2460

atttttttat ttaggtggat gcattttttg tctgtttact gctcttctca gctttattca   2520

ataaacttgc attttaaggg ttgt                                          2544


<210>  9086
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  9086

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Phe Leu Met Pro Trp Met Arg Asn Ser 
65                  70                  75              


<210>  9087
<211>  2712
<212>  DNA
<213>  Homosapiens

<400>  9087
tgccgcccgc cggtgtccgc ccgtgtcgcg ccggggcacc aaggagccgt tggagggtcc     60

gggcggaggc ccgctcgtgt ggaagtcgtc gacgccgccg ctcgtccgtc ctcccgtccg    120

ttctcgctcc cggccgccat catgctggcg ctcatctccc gcctgctgga ctggttccgt    180

tcgctcttct ggaaggaaga gatggagctg acgctcgtgg ggctgcagta ctcgggcaag    240

accaccttcg tcaatgtcat cgcgtcaggt caattcagtg aagatatgat acccacagtg    300

ggcttcaaca tgaggaaggt aactaaaggt aacgtcacaa taaagatctt cctaatgcct    360

tggatgagaa acagctaatt gaaaaaatga atctgtctgc tattcaggat agagaaattt    420

gctgctattc aatttcttgc aaagaaaagg ataatataga tatcacactt cagtggctta    480

ttcagcattc aaaatctaga agaagctgaa gcatctcctg aagtcttcca gtccttcttg    540

gctataatcc tagaattatt gtccgttcct ctgaagtaat tcccagaata cggtccttcc    600

taaaccccag aaattgcctt tttcagagtt tatttctcat gtgcactgct gaagatgaat    660

atccctaatc cttcataaag aatcagctag agttgtcatg ataaagtcag cacacacaaa    720

aaggcttctt acacatacct gtcttaaacc atgtgtagag ctttaaaaac agaaaaaaaa    780

ccccatatac ttatgaccat cttaaatcaa gaaaattgca tatttccatt ctggtctttc    840

tgggccagat ttttatattg gttttcagta aatgtctatc tataatattt cattatagag    900

tccagtagct taatactgac actgacttga tacagcatga agtttctagt gccacacaca    960

gtatttagaa aacctttagg cgtgaatgac tcatgtggga tatatgtaaa cataatgttt   1020

attttatctc acaaatgcat gtgaaatgta taattacatc ttaggaatcc aaaatggtct   1080

gcagagagtg agcggaggca ccagatcaat gttggttctt tgcactggtg agattctgcc   1140

tgatgaatat taaagatatc ctgctttctg agaactctat caccagatgg cagttgggat   1200

atgggaggaa ctaaagcatc ctgttttgta tctgtccaga tcattatttc tgtctcttgt   1260

tttttcttcc tggttcagga tactttttta aggggttgag aattgaagat tttccaaaag   1320

cgttcatgaa tttagagcat tccacccaat ataataaaac ctgttaagaa tgtcagtctt   1380

tgttcaaaca tctgtttgtt ctatctccag tcattaaatc agtgctgctg catgacactc   1440

ttaactcctg actttttata tccagtcata aagttgactt tcagcacaaa agatacttat   1500

aaacaaataa aaaattttta tttttctctc ttactgatgt aagctttggc actcttttga   1560

ctggtgccat tagacatctt gattattgtg acaactctag acctgcctgc tttatctaat   1620

gtaatcatgc tcaatgtcta caggttgttt aataatcagt cacacagaga actgaggaac   1680

tgatgctgtt tgtttgcttc tatgatacag agatgtctaa aaacttcaaa tggacatgtt   1740

ttgtagttta gcgacttccg tatacataaa gggacatatt aatactggtt catttgtaaa   1800

ttattattca tatagaccac tgtagtagat aaaactctat ggtacacctg cttatgtgtt   1860

gcctcacact gtgtgtgatt ttgtttcttt tgttaagcag cacttatgta gactgcattt   1920

ccaaatgtgt tgagcactca gagtgtagtc aacagtaagt tcttttaatg aatatcagtt   1980

ttaatttata gactgccatg gccttaaaaa tattctgtac aatatactgc actgtgttgc   2040

acagacacta cttgcttttc tccattcata tttttatgag tagaatctgg gcttttaaat   2100

ttctcttctt attctttgaa gcatgttgca tactaccctg gtgggatgga tggttctgta   2160

aatgaaggga tatttaaact tgctactgtt gttcaacacc attaatggtc agtgtgaacc   2220

attacaaaga atgtggcaac ttgcttgtgc ctaaaaggag gaattggaac tagaatgtgt   2280

gactctgtgg ggactgcata ggtttgttaa ttgacctata gctaaacctt aatgtgtttg   2340

tgtgtctata cattgctttc cgcatttcaa gacatccaga cgctattacc aacattttcc   2400

tgtgcattaa cctctgcatg tgaaaacttt taacagttac tgaactatgt aaatatgtga   2460

atttttttat ttaggtggat gcattttttg tctgtttact gctcttctca gctttattca   2520

ataaacttgc attttaaggg ttgtattggc aattttaact taaaatgtgc atcatgatgg   2580

aaggtgcaga cttttttgga agtttccgag aggagggtct atagaccatt tgtcagaaat   2640

cagatcagcc ctcaaagaat ggggtctgtg ggctagttaa aatagaaata aacttttaaa   2700

atatccacag aa                                                       2712


<210>  9088
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  9088

Met Leu Ala Leu Ile Ser Arg Leu Leu Asp Trp Phe Arg Ser Leu Phe 
1               5                   10                  15      


Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr Ser Gly 
            20                  25                  30          


Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Ser Glu Asp 
        35                  40                  45              


Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Val Thr Lys Gly Asn 
    50                  55                  60                  


Val Thr Ile Lys Ile Phe Leu Met Pro Trp Met Arg Asn Ser 
65                  70                  75              


<210>  9089
<211>  682
<212>  DNA
<213>  Homosapiens

<400>  9089
ggccttgggt ggatcgggtc tctgggcaga gcgtgtgtcc ggcagagcta ggaccggaaa     60

aagccactct aggtctaggt taggagtgat gacagttaaa agatatataa ggaaaagaag    120

gaaaggatcg tttctgtata aaacgagcta tttttgcata tcgagcgcat aagttttata    180

acttaggtgt ctgtttatgg agagggtggg atactacctt ttagctcaag gagtgcacaa    240

aacggtatca tgaattctgc tcttttgatt caaacaccca actttgaaga atcgctcatg    300

gtgcttgtaa aacacgtatc cccagatccc tccctagacc tatcgaacaa ctccaacggt    360

ctcgggaatg tgcgtggttt ctgaaaagct tgggaagcaa gacctgacta gacccccaaa    420

tctgatattg gctgaatggc cgaccaatgg agtgcataag aagtctggat acaaaggcag    480

cccaatttct agaaatgtat accagccatg aagagataaa gctccaagag gagatttctc    540

tttctggtat aaggatttaa acaaaaccta gaatgtcgca gtactcgaag tatccaaaac    600

aactgaaaaa tgaagaagaa taaaagaaga atccaaaagt atccaaaata actgaacata    660

tgaagaatca tggctgggca ca                                             682


<210>  9090
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  9090

Met Cys Val Val Ser Glu Lys Leu Gly Lys Gln Asp Leu Thr Arg Pro 
1               5                   10                  15      


Pro Asn Leu Ile Leu Ala Glu Trp Pro Thr Asn Gly Val His Lys Lys 
            20                  25                  30          


Ser Gly Tyr Lys Gly Ser Pro Ile Ser Arg Asn Val Tyr Gln Pro 
        35                  40                  45          


<210>  9091
<211>  1077
<212>  DNA
<213>  Homosapiens

<400>  9091
atagtaataa aactaatgag taaaattgaa caaagtgata agtatgacag ctgttctaag     60

cacagactta tccttttaat tcttctcata ggaatctgtc tgctattcag gatagagaaa    120

tttgctgcta ttcaatttct tgcaaagaaa aggataatat agatatcaca cttcagtggc    180

ttattcagca ttcaaaatct agaagaagct gaagcatctc ctgaagtctt ccagtccttc    240

ttggctataa tcctagaatt attgtccgtt cctctgaagt aattcccaga atacggtcct    300

tcctaaaccc cagaaattgc ctttttcaga gtttatttct catgtgcact gctgaagatg    360

aatatcccta atccttcata aagaatcagc tagagttgtc atgataaagt cagcacacac    420

aaaaaggctt cttacacata cctgtcttaa accatgtgta gagctttaaa aacagaaaaa    480

aaaccccata tacttatgac catcttaaat caagaaaatt gcatatttcc attctggtct    540

ttctgggcca gatttttata ttggttttca gtaaatgtct atctataata tttcattata    600

gagtccagta gcttaatact gacactgact tgatacagca tgaagtttct agtgccacac    660

acagtattta gaaaaccttt aggcgtgaat gactcatgtg ggatatatgt aaacataatg    720

tttattttat ctcacaaatg catgtgaaat gtataattac atcttaggaa tccaaaatgg    780

tctgcagaga gtgagcggag gcaccagatc aatgttggtt ctttgcactg gtgagattct    840

gcctgatgaa tattaaagat atcctgcttt ctgagaactc tatcaccaga tggcagttgg    900

gatatgggag gaactaaagc atcctgtttt gtatctgtcc agatcattat ttctgtctct    960

tgttttttct tcctggttca ggatactttt ttaaggggtt gagaattgaa gattttccaa   1020

aagcgttcat gaatttagag cattccaccc aatataataa aacctgttaa gaatgtc      1077


<210>  9092
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  9092

Met Ser Lys Ile Glu Gln Ser Asp Lys Tyr Asp Ser Cys Ser Lys His 
1               5                   10                  15      


Arg Leu Ile Leu Leu Ile Leu Leu Ile Gly Ile Cys Leu Leu Phe Arg 
            20                  25                  30          


Ile Glu Lys Phe Ala Ala Ile Gln Phe Leu Ala Lys Lys Arg Ile Ile 
        35                  40                  45              


<210>  9093
<211>  2247
<212>  DNA
<213>  Homosapiens

<400>  9093
atagtaataa aactaatgag taaaattgaa caaagtgata agtatgacag ctgttctaag     60

cacagactta tccttttaat tcttctcata ggaatctgtc tgctattcag gatagagaaa    120

tttgctgcta ttcaatttct tgcaaagaaa aggataatat agatatcaca cttcagtggc    180

ttattcagca ttcaaaatct agaagaagct gaagcatctc ctgaagtctt ccagtccttc    240

ttggctataa tcctagaatt attgtccgtt cctctgaagt aattcccaga atacggtcct    300

tcctaaaccc cagaaattgc ctttttcaga gtttatttct catgtgcact gctgaagatg    360

aatatcccta atccttcata aagaatcagc tagagttgtc atgataaagt cagcacacac    420

aaaaaggctt cttacacata cctgtcttaa accatgtgta gagctttaaa aacagaaaaa    480

aaaccccata tacttatgac catcttaaat caagaaaatt gcatatttcc attctggtct    540

ttctgggcca gatttttata ttggttttca gtaaatgtct atctataata tttcattata    600

gagtccagta gcttaatact gacactgact tgatacagca tgaagtttct agtgccacac    660

acagtattta gaaaaccttt aggcgtgaat gactcatgtg ggatatatgt aaacataatg    720

tttattttat ctcacaaatg catgtgaaat gtataattac atcttaggaa tccaaaatgg    780

tctgcagaga gtgagcggag gcaccagatc aatgttggtt ctttgcactg gtgagattct    840

gcctgatgaa tattaaagat atcctgcttt ctgagaactc tatcaccaga tggcagttgg    900

gatatgggag gaactaaagc atcctgtttt gtatctgtcc agatcattat ttctgtctct    960

tgttttttct tcctggttca ggatactttt ttaaggggtt gagaattgaa gattttccaa   1020

aagcgttcat gaatttagag cattccaccc aatataataa aacctgttaa gaatgtcagt   1080

ctttgttcaa acatctgttt gttctatctc cagtcattaa atcagtgctg ctgcatgaca   1140

ctcttaactc ctgacttttt atatccagtc ataaagttga ctttcagcac aaaagatact   1200

tataaacaaa taaaaaattt ttatttttct ctcttactga tgtaagcttt ggcactcttt   1260

tgactggtgc cattagacat cttgattatt gtgacaactc tagacctgcc tgctttatct   1320

aatgtaatca tgctcaatgt ctacaggttg tttaataatc agtcacacag agaactgagg   1380

aactgatgct gtttgtttgc ttctatgata cagagatgtc taaaaacttc aaatggacat   1440

gttttgtagt ttagcgactt ccgtatacat aaagggacat attaatactg gttcatttgt   1500

aaattattat tcatatagac cactgtagta gataaaactc tatggtacac ctgcttatgt   1560

gttgcctcac actgtgtgtg attttgtttc ttttgttaag cagcacttat gtagactgca   1620

tttccaaatg tgttgagcac tcagagtgta gtcaacagta agttctttta atgaatatca   1680

gttttaattt atagactgcc atggccttaa aaatattctg tacaatatac tgcactgtgt   1740

tgcacagaca ctacttgctt ttctccattc atatttttat gagtagaatc tgggctttta   1800

aatttctctt cttattcttt gaagcatgtt gcatactacc ctggtgggat ggatggttct   1860

gtaaatgaag ggatatttaa acttgctact gttgttcaac accattaatg gtcagtgtga   1920

accattacaa agaatgtggc aacttgcttg tgcctaaaag gaggaattgg aactagaatg   1980

tgtgactctg tggggactgc ataggtttgt taattgacct atagctaaac cttaatgtgt   2040

ttgtgtgtct atacattgct ttccgcattt caagacatcc agacgctatt accaacattt   2100

tcctgtgcat taacctctgc atgtgaaaac ttttaacagt tactgaacta tgtaaatatg   2160

tgaatttttt tatttaggtg gatgcatttt ttgtctgttt actgctcttc tcagctttat   2220

tcaataaact tgcattttaa gggttgt                                       2247


<210>  9094
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  9094

Met Ala Leu Lys Ile Phe Cys Thr Ile Tyr Cys Thr Val Leu His Arg 
1               5                   10                  15      


His Tyr Leu Leu Phe Ser Ile His Ile Phe Met Ser Arg Ile Trp Ala 
            20                  25                  30          


Phe Lys Phe Leu Phe Leu Phe Phe Glu Ala Cys Cys Ile Leu Pro Trp 
        35                  40                  45              


Trp Asp Gly Trp Phe Cys Lys 
    50                  55  


<210>  9095
<211>  2415
<212>  DNA
<213>  Homosapiens

<400>  9095
atagtaataa aactaatgag taaaattgaa caaagtgata agtatgacag ctgttctaag     60

cacagactta tccttttaat tcttctcata ggaatctgtc tgctattcag gatagagaaa    120

tttgctgcta ttcaatttct tgcaaagaaa aggataatat agatatcaca cttcagtggc    180

ttattcagca ttcaaaatct agaagaagct gaagcatctc ctgaagtctt ccagtccttc    240

ttggctataa tcctagaatt attgtccgtt cctctgaagt aattcccaga atacggtcct    300

tcctaaaccc cagaaattgc ctttttcaga gtttatttct catgtgcact gctgaagatg    360

aatatcccta atccttcata aagaatcagc tagagttgtc atgataaagt cagcacacac    420

aaaaaggctt cttacacata cctgtcttaa accatgtgta gagctttaaa aacagaaaaa    480

aaaccccata tacttatgac catcttaaat caagaaaatt gcatatttcc attctggtct    540

ttctgggcca gatttttata ttggttttca gtaaatgtct atctataata tttcattata    600

gagtccagta gcttaatact gacactgact tgatacagca tgaagtttct agtgccacac    660

acagtattta gaaaaccttt aggcgtgaat gactcatgtg ggatatatgt aaacataatg    720

tttattttat ctcacaaatg catgtgaaat gtataattac atcttaggaa tccaaaatgg    780

tctgcagaga gtgagcggag gcaccagatc aatgttggtt ctttgcactg gtgagattct    840

gcctgatgaa tattaaagat atcctgcttt ctgagaactc tatcaccaga tggcagttgg    900

gatatgggag gaactaaagc atcctgtttt gtatctgtcc agatcattat ttctgtctct    960

tgttttttct tcctggttca ggatactttt ttaaggggtt gagaattgaa gattttccaa   1020

aagcgttcat gaatttagag cattccaccc aatataataa aacctgttaa gaatgtcagt   1080

ctttgttcaa acatctgttt gttctatctc cagtcattaa atcagtgctg ctgcatgaca   1140

ctcttaactc ctgacttttt atatccagtc ataaagttga ctttcagcac aaaagatact   1200

tataaacaaa taaaaaattt ttatttttct ctcttactga tgtaagcttt ggcactcttt   1260

tgactggtgc cattagacat cttgattatt gtgacaactc tagacctgcc tgctttatct   1320

aatgtaatca tgctcaatgt ctacaggttg tttaataatc agtcacacag agaactgagg   1380

aactgatgct gtttgtttgc ttctatgata cagagatgtc taaaaacttc aaatggacat   1440

gttttgtagt ttagcgactt ccgtatacat aaagggacat attaatactg gttcatttgt   1500

aaattattat tcatatagac cactgtagta gataaaactc tatggtacac ctgcttatgt   1560

gttgcctcac actgtgtgtg attttgtttc ttttgttaag cagcacttat gtagactgca   1620

tttccaaatg tgttgagcac tcagagtgta gtcaacagta agttctttta atgaatatca   1680

gttttaattt atagactgcc atggccttaa aaatattctg tacaatatac tgcactgtgt   1740

tgcacagaca ctacttgctt ttctccattc atatttttat gagtagaatc tgggctttta   1800

aatttctctt cttattcttt gaagcatgtt gcatactacc ctggtgggat ggatggttct   1860

gtaaatgaag ggatatttaa acttgctact gttgttcaac accattaatg gtcagtgtga   1920

accattacaa agaatgtggc aacttgcttg tgcctaaaag gaggaattgg aactagaatg   1980

tgtgactctg tggggactgc ataggtttgt taattgacct atagctaaac cttaatgtgt   2040

ttgtgtgtct atacattgct ttccgcattt caagacatcc agacgctatt accaacattt   2100

tcctgtgcat taacctctgc atgtgaaaac ttttaacagt tactgaacta tgtaaatatg   2160

tgaatttttt tatttaggtg gatgcatttt ttgtctgttt actgctcttc tcagctttat   2220

tcaataaact tgcattttaa gggttgtatt ggcaatttta acttaaaatg tgcatcatga   2280

tggaaggtgc agactttttt ggaagtttcc gagaggaggg tctatagacc atttgtcaga   2340

aatcagatca gccctcaaag aatggggtct gtgggctagt taaaatagaa ataaactttt   2400

aaaatatcca cagaa                                                    2415


<210>  9096
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  9096

Met Ala Leu Lys Ile Phe Cys Thr Ile Tyr Cys Thr Val Leu His Arg 
1               5                   10                  15      


His Tyr Leu Leu Phe Ser Ile His Ile Phe Met Ser Arg Ile Trp Ala 
            20                  25                  30          


Phe Lys Phe Leu Phe Leu Phe Phe Glu Ala Cys Cys Ile Leu Pro Trp 
        35                  40                  45              


Trp Asp Gly Trp Phe Cys Lys 
    50                  55  


<210>  9097
<211>  1558
<212>  DNA
<213>  Homosapiens

<400>  9097
ttcagtggct tattcagcat tcaaaatcta gaagaagctg aagcatctcc tgaagtcttc     60

cagtccttct tggctataat cctagaatta ttgtccgttc ctctgaagta attcccagaa    120

tacggtcctt cctaaacccc agaaattgcc tttttcagag tttatttctc atgtgcactg    180

ctgaagatga atatccctaa tccttcataa agaatcagct agagttgtca tgataaagtc    240

agcacacaca aaaaggcttc ttacacatac ctgtcttaaa ccatgtgtag agctttaaaa    300

acagaaaaaa aaccccatat acttatgacc atcttaaatc aagaaaattg catatttcca    360

ttctggtctt tctgggccag atttttatat tggttttcag taaatgtcta tctataatat    420

ttcattatag agtccagtag cttaatactg acactgactt gatacagcat gaagtttcta    480

gtgccacaca cagtatttag aaaaccttta ggcgtgaatg actcatgtgg gatatatgta    540

aacataatgt ttattttatc tcacaaatgc atgtgaaatg tataattaca tcttaggaat    600

ccaaaatggt ctgcagagag tgagcggagg caccagatca atgttggttc tttgcactgg    660

tgagattctg cctgatgaat attaaagata tcctgctttc tgagaactct atcaccagat    720

ggcagttggg atatgggagg aactaaagca tcctgttttg tatctgtcca gatcattatt    780

tctgtctctt gttttttctt cctggttcag gatacttttt taaggggttg agaattgaag    840

attttccaaa agcgttcatg aatttagagc attccaccca atataataaa acctgttaag    900

aatgtcagtc tttgttcaaa catctgtttg ttctatctcc agtcattaaa tcagtgctgc    960

tgcatgacac tcttaactcc tgacttttta tatccagtca taaagttgac tttcagcaca   1020

aaagatactt ataaacaaat aaaaaatttt tatttttctc tcttactgat gtaagctttg   1080

gcactctttt gactggtgcc attagacatc ttgattattg tgacaactct agacctgcct   1140

gctttattac cctggtggga tggatggttc tgtaaatgaa gggatattta aacttgctac   1200

tgttgttcaa caccattaat ggtcagtgtg aaccattaca aagaatgtgg caacttgctt   1260

gtgcctaaaa ggaggaattg gaactagaat gtgtgactct gtggggactg cataggtttg   1320

ttaattgacc tatagctaaa ccttaatgtg tttgtgtgtc tatacattgc tttccgcatt   1380

tcaagacatc cagacgctat taccaacatt ttcctgtgca ttaacctctg catgtgaaaa   1440

cttttaacag ttactgaact atgtaaatat gtgaattttt ttatttaggt ggatgcattt   1500

tttgtctgtt tactgctctt ctcagcttta ttcaataaac ttgcatttta agggttgt     1558


<210>  9098
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  9098

Met Cys Arg Ala Leu Lys Thr Glu Lys Lys Pro His Ile Leu Met Thr 
1               5                   10                  15      


Ile Leu Asn Gln Glu Asn Cys Ile Phe Pro Phe Trp Ser Phe Trp Ala 
            20                  25                  30          


Arg Phe Leu Tyr Trp Phe Ser Val Asn Val Tyr Leu 
        35                  40                  


<210>  9099
<211>  1726
<212>  DNA
<213>  Homosapiens

<400>  9099
ttcagtggct tattcagcat tcaaaatcta gaagaagctg aagcatctcc tgaagtcttc     60

cagtccttct tggctataat cctagaatta ttgtccgttc ctctgaagta attcccagaa    120

tacggtcctt cctaaacccc agaaattgcc tttttcagag tttatttctc atgtgcactg    180

ctgaagatga atatccctaa tccttcataa agaatcagct agagttgtca tgataaagtc    240

agcacacaca aaaaggcttc ttacacatac ctgtcttaaa ccatgtgtag agctttaaaa    300

acagaaaaaa aaccccatat acttatgacc atcttaaatc aagaaaattg catatttcca    360

ttctggtctt tctgggccag atttttatat tggttttcag taaatgtcta tctataatat    420

ttcattatag agtccagtag cttaatactg acactgactt gatacagcat gaagtttcta    480

gtgccacaca cagtatttag aaaaccttta ggcgtgaatg actcatgtgg gatatatgta    540

aacataatgt ttattttatc tcacaaatgc atgtgaaatg tataattaca tcttaggaat    600

ccaaaatggt ctgcagagag tgagcggagg caccagatca atgttggttc tttgcactgg    660

tgagattctg cctgatgaat attaaagata tcctgctttc tgagaactct atcaccagat    720

ggcagttggg atatgggagg aactaaagca tcctgttttg tatctgtcca gatcattatt    780

tctgtctctt gttttttctt cctggttcag gatacttttt taaggggttg agaattgaag    840

attttccaaa agcgttcatg aatttagagc attccaccca atataataaa acctgttaag    900

aatgtcagtc tttgttcaaa catctgtttg ttctatctcc agtcattaaa tcagtgctgc    960

tgcatgacac tcttaactcc tgacttttta tatccagtca taaagttgac tttcagcaca   1020

aaagatactt ataaacaaat aaaaaatttt tatttttctc tcttactgat gtaagctttg   1080

gcactctttt gactggtgcc attagacatc ttgattattg tgacaactct agacctgcct   1140

gctttattac cctggtggga tggatggttc tgtaaatgaa gggatattta aacttgctac   1200

tgttgttcaa caccattaat ggtcagtgtg aaccattaca aagaatgtgg caacttgctt   1260

gtgcctaaaa ggaggaattg gaactagaat gtgtgactct gtggggactg cataggtttg   1320

ttaattgacc tatagctaaa ccttaatgtg tttgtgtgtc tatacattgc tttccgcatt   1380

tcaagacatc cagacgctat taccaacatt ttcctgtgca ttaacctctg catgtgaaaa   1440

cttttaacag ttactgaact atgtaaatat gtgaattttt ttatttaggt ggatgcattt   1500

tttgtctgtt tactgctctt ctcagcttta ttcaataaac ttgcatttta agggttgtat   1560

tggcaatttt aacttaaaat gtgcatcatg atggaaggtg cagacttttt tggaagtttc   1620

cgagaggagg gtctatagac catttgtcag aaatcagatc agccctcaaa gaatggggtc   1680

tgtgggctag ttaaaataga aataaacttt taaaatatcc acagaa                  1726


<210>  9100
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  9100

Met Cys Arg Ala Leu Lys Thr Glu Lys Lys Pro His Ile Leu Met Thr 
1               5                   10                  15      


Ile Leu Asn Gln Glu Asn Cys Ile Phe Pro Phe Trp Ser Phe Trp Ala 
            20                  25                  30          


Arg Phe Leu Tyr Trp Phe Ser Val Asn Val Tyr Leu 
        35                  40                  


<210>  9101
<211>  6161
<212>  DNA
<213>  Homosapiens

<400>  9101
ggacgatggg ctagttcctg gtgcgtcacg ggggagttcc ttaaagggga agcgagccgg     60

gctacggggc gagcgcgggg tgcggtggtc ggcggggagg cccccgcgct ttaaaataat    120

gcccgcggcg cccgcgcgac catgcaatgg cgagcgctcg tcctggggct ggtgctcctc    180

cggcttggcc tccatggagt attgtggctc gtcttcgggc tggggcccag catgggcttc    240

taccagcgct ttccgctcag cttcggcttc cagcgtctga ggagccccga cggccccgcg    300

tcgcccacct cggggcccgt gggccggcct gggggggtat ccgggccgtc gtggctgcag    360

ccgccgggga ccggggcagc gcagagcccg cgcaaggctc cgcggcgtcc tgggccgggg    420

atgtgcggcc cagccaactg gggctacgtg ctgggcggcc ggggccgcgg cccggacgag    480

tacgagaagc gctacagcgg cgccttccct ccgcagctgc gtgcccagat gcgcgacctg    540

gcacggggca tgttcgtctt tggctacgac aactacatgg ctcacgcctt cccccaggac    600

gagctcaacc ccatccactg ccgcggccgt gggcccgacc gcggggaccc ttcaaatctg    660

aacatcaatg atgtactagg gaactactca ttgactcttg ttgatgcatt ggatacactt    720

gcaataatgg gaaattcatc cgagttccag aaagccgtca agttagtgat caacacagtt    780

tcatttgaca aagattccac cgtccaagtc tttgaggcca cgataagggt cctgggaagc    840

ctcctttctg ctcacagaat aataactgac tccaagcagc cctttggtga catgacaatt    900

aaggactatg ataatgagtt gttatacatg gcccatgacc tggcggtgcg gctcctccct    960

gcttttgaaa acaccaagac agggattcca tatcctcggg tgaatctaaa gacaggagtt   1020

cctcctgaca ccaataatga gacatgcaca gcgggagccg gttccctcct ggtggaattt   1080

gggattctga gtcgactcct gggggactcc acatttgagt gggtggccag acgagcagtg   1140

aaagcccttt ggaacctccg gagcaatgat acaggattac taggcaatgt cgtgaacatt   1200

cagacgggcc actgggttgg aaagcagagt ggcctgggtg ccgggctgga ctccttctat   1260

gaatacctct tgaaatctta cattctcttt ggagaaaaag aagacctaga aatgtttaat   1320

gctgcatatc agagtattca gaactactta agaagagggc gggaagcctg caatgaagga   1380

gaaggagacc ctccactcta tgtcaacgtg aacatgttca gtgggcagct gatgaacacc   1440

tggattgact ctctgcaggc ctttttccct ggactgcagg tgctgatagg agatgtggaa   1500

gatgccatct gccttcatgc cttctactat gccatatgga aacgatatgg tgccctccct   1560

gagagatata actggcagct gcaggcccct gacgttctct tctacccact gagaccagag   1620

ttagtggaat ccacatatct cctctaccag gcaaccaaga atcccttcta cctccatgta   1680

ggaatggata ttctgcagag tctggaaaag tacacaaaag tcaagtgtgg gtacgccacg   1740

ctgcatcacg tcattgacaa gtccacagaa gaccggatgg agagcttctt tctcagtgag   1800

acctgtaaat atttgtatct gctgtttgat gaagacaatc cagtacacaa gtctggaacc   1860

agatacatgt tcacaacaga gggacacatt gtatctgtgg atgagcatct tcgggaattg   1920

ccatggaagg aattcttctc tgaagaggga gggcaggacc aagggggaaa gtctgtgcac   1980

aggccgaaac ctcatgagtt aaaagtcatc aactccagct ccaactgcaa tcgtgtacct   2040

gatgagagga ggtactccct gcccttaaag agcatctaca tgcgacagat tgaccagatg   2100

gttggtttga tttgatctgc tctctgtgag gcctcatctt gaaccagacc ttaacgacca   2160

aacccagacc atgccaaagt ccagtctgaa atgaaagggg acagaagtct tgctgtccat   2220

ggtggtgtag gaatttctgt gcaacacctc accacgtctg gttaatcctt gcacacttca   2280

gtgtttctct cctgttcaat aaaatgccct gttaaggata taatttgaag tgagaagata   2340

catggaaatt gccctcttat gacatgttga tgttataagc acaatagatg gggcatcttt   2400

ggattgatgt tcacagcttt atacttcaga acctaagtct cttcactttg ctggcacctg   2460

ctatactgga gtattgctat gtctttaaaa aatttttttt attatatttt atttttttga   2520

gacagggtct tgatattttt ttgggacagg gttacctggg ctcaagtgat ccttctgcct   2580

cagcctcccg agtagctggg attacaggtg agcaccactg tacctggcta gctacttctt   2640

tgttagagga ttgagaatga aatttctgca aaagggccca tggttcattt ggtatcccta   2700

tttaattgca ttgaaaatgt catcctttct gttgttagat aattggggtc ttcccctgat   2760

atccaaccgt gattttggat cacatgggag aaaaagtcat ccagtttttc atgtttgcct   2820

caagtaatct ttacagtgtt acaaattatt tgcttaagaa gaatggtctt aaccagaatt   2880

cttaacagat agtctcttag gttattatgt tatggtctaa gaggttaact gacatctttt   2940

gggtggtatt ttgcattttg aatatgaact tacctgagga actcccatag ttccagaatc   3000

aggtgccttt tagggagaga acaataccta agattgtctg agcttccatc tttctcatat   3060

ttcctaagca aggattctca cttctgacca tatttgggtt agagttctgt tttgtttctg   3120

ttttctgtgt ctagtgccaa ttagctaaat cagggagaaa gaaatgatca catgactttt   3180

agcatccttg agccatttct ctgtgtaata caggctttag attagtgcct tatattggtt   3240

ttggtttggg gcactggatg tcgcagctac tgctatggtt tcaggaggcc tgtttagcca   3300

catggtgaga ccgtggtgaa agggggatgg aaattgcttg gccagtcttt gcctttcatc   3360

ctgtaaaagt aagcatgtag aaggaggaag ttgtgctaaa atgcctttgt ttttttgtta   3420

ttattttctt agccagaaca tctctctttg aactcacact gatacacacc tgctactctt   3480

acacagtgca gcagggttga ctcttagtct ggcttccatg aagcgtcatg ggtggaaacg   3540

cattctagta aaaaaggtag gaaatcccta aaacttccag cctcacatag cacggttctc   3600

acctgtcact gttttcccac ctctaaggat ttcatgtaca tcttttcaaa gctagaaata   3660

agcactgtct aagtttatgt tgcattttta gtcaaaaggg agaaatctta ttccttcttg   3720

aaaattttaa gtgttatggt tttatatagt tcagttcttt gagatttttg aaaagagtat   3780

tttcagtaat aaacgtgcca tctctatctc ttaaacattt attacaacaa ttgttttaaa   3840

atagaaaaaa taaaatgctt ctattttacc ttttttcatt tcagaagcat tattctgttt   3900

attaacagtg tcccatctac tgaatagaaa actttgagaa taatatatat atatatttta   3960

aatgttttca ctgactcatt gaaaatgtta attacacaca catgcatgca tgcacacacg   4020

agcatacttg tacctttgtc tctgggcaaa caggtgggac tgttagtgac ccatttggga   4080

aaatagagca tctcagagaa ggaggtgagt tcttcctgcc tgtgatttct cttggcgctc   4140

ccctcctctc ccgctctggc ttctgtggcg gcagtggtgg gtaagcactc cagtgttctc   4200

ttaatgaggc actttgcctg tcactcgagc aagcctgggt gttccttcct cctcatgctc   4260

ctggaatagg gaatagggat ctcatgcttg caaactacac aatgctgcag gtgcttccca   4320

ggggccacag gctgtcagga aacgtgtttt atgttaagtc acaaacccac ttgacttctg   4380

ggtactggaa ttaataccag tgggtgagac tgagggtgag tgagttagta catattaatc   4440

ctggttgttg agcttccaga ctaccccgtc caaagtttga tgctatgtag tcagtggttt   4500

gtggggctgg atgccagaag gttctttgag ccagtttcaa aggttacttg tttttttttt   4560

ttttttttaa agtcagaatg ttaacagctg tgatatatcc tgcagggctt ttgcagtttc   4620

ttctgttctg tgttctgaaa tactgggtag agaatggctg aggaggagat taccagagaa   4680

gttgctttgc tcagtgcttt gccccaggat tgcctcaaat ctgagtggac ttcatccttt   4740

gcggcggctc tgagcctggc ccatcttcct attcccacgt gtagctagtg tctagtgtca   4800

gctttgctca gtgtggtgga aacattttgc agaactgttg tagaaagctg ccttatagtt   4860

ggcttgacaa agcataattc tctcataaca aactttcaaa tcattacagt agcttagcta   4920

ctttagttga tgtgaccgag gaatcccttc tagaatcata ggtggcaagg gagggtttgc   4980

tagctctcca tttgcactgg ccattgtgaa aaaccagctt ctgtattcaa atctttcctt   5040

cattttttta aatttttttt ttggcagcgc ttgtgctgga acttactcat tgtaactgaa   5100

tcctcagggc ttttcttgtt ttagatcatg gactgtgcac gtgacactta aataattttc   5160

tatgtattta aagaaaaatg caccaggatg gtgtctgtgc acgtgactat tagaggagcg   5220

tctgtagaag tacctggttt ggtcagtgca gttgtgcaat ctgagggcct tgtttcctcc   5280

tcccctttcc ccttctcccc accaaaggaa aatatccctc ttaatgattt cgtagttcag   5340

tttactgaat gattaccacc tgtaattcct ctttggattg tgtagactca acatgagaca   5400

ttcctttctg ctttctggag ggcaccaggg gcctttctct ttgataaatt ttttttgtct   5460

gttgacaaaa acaaaaatct tttttcaaat gtagtgctgg tgaaaaggta gggctgagtg   5520

attaccttag ccacagggtg gctgagcagg aactttagaa gaaaatcctg agctttcctg   5580

tccattccca gcatccagct cctattctag tgcctcttcc ctgcagggca gggacccctt   5640

gggaaatcga ggaggtggga cgggctgggc cctgtgtccc aggtttcaca gggctcaggg   5700

ttatgctccc gcttgaatct ggacgtgaat ctggtaaaaa tatcaagtac ctgtggaact   5760

ccctgattct ataccctctt ccttctttct gcaaggcaga ggaataatat ttttaaaggt   5820

tattttgttt tagttttaaa tagcaaaaca caagctgcat ttttatttat tttgcataag   5880

aaaggtaaat ctttttacaa aaaaaagtat agagttggaa actctgggaa aacttacgga   5940

aatacacaaa tgcttctctg taatgtgcaa tatgctttgc aactgtagat gatattttat   6000

gtttaatctg taaataagaa atgtatttaa attaaaaggg atctttttgt aaaaggacca   6060

aatgttcttt tataaatgta ataaggaata tcttgctctt taaaatttat taggattttt   6120

atgagtaatt tttattaaaa gatttctttt tttgagttgt c                       6161


<210>  9102
<211>  657
<212>  PRT
<213>  Homosapiens

<400>  9102

Met Gln Trp Arg Ala Leu Val Leu Gly Leu Val Leu Leu Arg Leu Gly 
1               5                   10                  15      


Leu His Gly Val Leu Trp Leu Val Phe Gly Leu Gly Pro Ser Met Gly 
            20                  25                  30          


Phe Tyr Gln Arg Phe Pro Leu Ser Phe Gly Phe Gln Arg Leu Arg Ser 
        35                  40                  45              


Pro Asp Gly Pro Ala Ser Pro Thr Ser Gly Pro Val Gly Arg Pro Gly 
    50                  55                  60                  


Gly Val Ser Gly Pro Ser Trp Leu Gln Pro Pro Gly Thr Gly Ala Ala 
65                  70                  75                  80  


Gln Ser Pro Arg Lys Ala Pro Arg Arg Pro Gly Pro Gly Met Cys Gly 
                85                  90                  95      


Pro Ala Asn Trp Gly Tyr Val Leu Gly Gly Arg Gly Arg Gly Pro Asp 
            100                 105                 110         


Glu Tyr Glu Lys Arg Tyr Ser Gly Ala Phe Pro Pro Gln Leu Arg Ala 
        115                 120                 125             


Gln Met Arg Asp Leu Ala Arg Gly Met Phe Val Phe Gly Tyr Asp Asn 
    130                 135                 140                 


Tyr Met Ala His Ala Phe Pro Gln Asp Glu Leu Asn Pro Ile His Cys 
145                 150                 155                 160 


Arg Gly Arg Gly Pro Asp Arg Gly Asp Pro Ser Asn Leu Asn Ile Asn 
                165                 170                 175     


Asp Val Leu Gly Asn Tyr Ser Leu Thr Leu Val Asp Ala Leu Asp Thr 
            180                 185                 190         


Leu Ala Ile Met Gly Asn Ser Ser Glu Phe Gln Lys Ala Val Lys Leu 
        195                 200                 205             


Val Ile Asn Thr Val Ser Phe Asp Lys Asp Ser Thr Val Gln Val Phe 
    210                 215                 220                 


Glu Ala Thr Ile Arg Val Leu Gly Ser Leu Leu Ser Ala His Arg Ile 
225                 230                 235                 240 


Ile Thr Asp Ser Lys Gln Pro Phe Gly Asp Met Thr Ile Lys Asp Tyr 
                245                 250                 255     


Asp Asn Glu Leu Leu Tyr Met Ala His Asp Leu Ala Val Arg Leu Leu 
            260                 265                 270         


Pro Ala Phe Glu Asn Thr Lys Thr Gly Ile Pro Tyr Pro Arg Val Asn 
        275                 280                 285             


Leu Lys Thr Gly Val Pro Pro Asp Thr Asn Asn Glu Thr Cys Thr Ala 
    290                 295                 300                 


Gly Ala Gly Ser Leu Leu Val Glu Phe Gly Ile Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Gly Asp Ser Thr Phe Glu Trp Val Ala Arg Arg Ala Val Lys Ala Leu 
                325                 330                 335     


Trp Asn Leu Arg Ser Asn Asp Thr Gly Leu Leu Gly Asn Val Val Asn 
            340                 345                 350         


Ile Gln Thr Gly His Trp Val Gly Lys Gln Ser Gly Leu Gly Ala Gly 
        355                 360                 365             


Leu Asp Ser Phe Tyr Glu Tyr Leu Leu Lys Ser Tyr Ile Leu Phe Gly 
    370                 375                 380                 


Glu Lys Glu Asp Leu Glu Met Phe Asn Ala Ala Tyr Gln Ser Ile Gln 
385                 390                 395                 400 


Asn Tyr Leu Arg Arg Gly Arg Glu Ala Cys Asn Glu Gly Glu Gly Asp 
                405                 410                 415     


Pro Pro Leu Tyr Val Asn Val Asn Met Phe Ser Gly Gln Leu Met Asn 
            420                 425                 430         


Thr Trp Ile Asp Ser Leu Gln Ala Phe Phe Pro Gly Leu Gln Val Leu 
        435                 440                 445             


Ile Gly Asp Val Glu Asp Ala Ile Cys Leu His Ala Phe Tyr Tyr Ala 
    450                 455                 460                 


Ile Trp Lys Arg Tyr Gly Ala Leu Pro Glu Arg Tyr Asn Trp Gln Leu 
465                 470                 475                 480 


Gln Ala Pro Asp Val Leu Phe Tyr Pro Leu Arg Pro Glu Leu Val Glu 
                485                 490                 495     


Ser Thr Tyr Leu Leu Tyr Gln Ala Thr Lys Asn Pro Phe Tyr Leu His 
            500                 505                 510         


Val Gly Met Asp Ile Leu Gln Ser Leu Glu Lys Tyr Thr Lys Val Lys 
        515                 520                 525             


Cys Gly Tyr Ala Thr Leu His His Val Ile Asp Lys Ser Thr Glu Asp 
    530                 535                 540                 


Arg Met Glu Ser Phe Phe Leu Ser Glu Thr Cys Lys Tyr Leu Tyr Leu 
545                 550                 555                 560 


Leu Phe Asp Glu Asp Asn Pro Val His Lys Ser Gly Thr Arg Tyr Met 
                565                 570                 575     


Phe Thr Thr Glu Gly His Ile Val Ser Val Asp Glu His Leu Arg Glu 
            580                 585                 590         


Leu Pro Trp Lys Glu Phe Phe Ser Glu Glu Gly Gly Gln Asp Gln Gly 
        595                 600                 605             


Gly Lys Ser Val His Arg Pro Lys Pro His Glu Leu Lys Val Ile Asn 
    610                 615                 620                 


Ser Ser Ser Asn Cys Asn Arg Val Pro Asp Glu Arg Arg Tyr Ser Leu 
625                 630                 635                 640 


Pro Leu Lys Ser Ile Tyr Met Arg Gln Ile Asp Gln Met Val Gly Leu 
                645                 650                 655     


Ile 
    


<210>  9103
<211>  2319
<212>  DNA
<213>  Homosapiens

<400>  9103
ggctagttcc tggtgcgtca cgggggagtt ccttaaaggg gaagcgagcc gggctacggg     60

gcgagcgcgg ggtgcggtgg tcggcgggga ggcccccgcg ctttaaaata atgcccgcgg    120

cgcccgcgcg accatgcaat ggcgagcgct cgtcctgggg ctggtgctcc tccggcttgg    180

cctccatgga gtattgtggc tcgtcttcgg gctggggccc agcatgggct tctaccagcg    240

ctttccgctc agcttcggct tccagcgtct gaggagcccc gacggccccg cgtcgcccac    300

ctcggggccc gtgggccggc ctgggggggt atccgggccg tcgtggctgc agccgccggg    360

gaccggggca gcgcagagcc cgcgcaaggc tccgcggcgt cctgggccgg ggatgtgcgg    420

cccagccaac tggggctacg tgctgggcgg ccggggccgc ggcccggacg agtacgagaa    480

gcgctacagc ggcgccttcc ctccgcagct gcgtgcccag atgcgcgacc tggcacgggg    540

catgttcgtc tttggctacg acaactacat ggctcacgcc ttcccccagg acgagctcaa    600

ccccatccac tgccgcggcc gtgggcccga ccgcggggac ccttcaaatc tgaacatcaa    660

tgatgtacta gggaactact cattgactct tgttgatgca ttggatacac ttgcaataat    720

gggaaattca tccgagttcc agaaagccgt caagttagtg atcaacacag tttcatttga    780

caaagattcc accgtccaag tctttgaggc cacgataagg gtcctgggaa gcctcctttc    840

tgctcacaga ataataactg actccaagca gccctttggt gacatgacaa ttaaggacta    900

tgataatgag ttgttataca tggcccatga cctggcggtg cggctcctcc ctgcttttga    960

aaacaccaag acagggattc catatcctcg ggtgaatcta aagacaggag ttcctcctga   1020

caccaataat gagacatgca cagcgggagc cggttccctc ctggtggaat ttgggattct   1080

gagtcgactc ctgggggact ccacatttga gtgggtggcc agacgagcag tgaaagccct   1140

ttggaacctc cggagcaatg atacaggatt actaggcaat gtcgtgaaca ttcagacggg   1200

ccactgggtt ggaaagcaga gtggcctggg tgccgggctg gactccttct atgaatacct   1260

cttgaaatct tacattctct ttggagaaaa agaagaccta gaaatgttta atgctgcata   1320

tcagagtatt cagaactact taagaagagg gcgggaagcc tgcaatgaag gagaaggaga   1380

ccctccactc tatgtcaacg tgaacatgtt cagtgggcag ctgatgaaca cctggattga   1440

ctctctgcag gcctttttcc ctggactgca ggtgctgata ggagatgtgg aagatgccat   1500

ctgccttcat gccttctact atgccatatg gaaacgatat ggtgccctcc ctgagagata   1560

taactggcag ctgcaggccc ctgacgttct cttctaccca ctgagaccag agttagtgga   1620

atccacatat ctcctctacc aggcaaccaa gaatcccttc tacctccatg taggaatgga   1680

tattctgcag agtctggaaa agtacacaaa agtcaagtgt gggtacgcca cgctgcatca   1740

cgtcattgac aagtccacag aagaccggat ggagagcttc tttctcagtg agacctgtaa   1800

atatttgtat ctgctgtttg atgaagacaa tccagtacac aagtctggaa ccagatacat   1860

gttcacaaca gagggacaca ttgtatctgt ggatgagcat cttcgggaat tgccatggaa   1920

ggaattcttc tctgaagagg gagggcagga ccaaggggga aagtctgtgc acaggccgaa   1980

acctcatgag ttaaaagtca tcaactccag ctccaactgc aatcgtgtac ctgatgagag   2040

gaggtactcc ctgcccttaa agagcatcta catgcgacag attgaccaga tggttggttt   2100

gatttgatct gctctctgtg aggcctcatc ttgaaccaga ccttaacgac caaacccaga   2160

ccatgccaaa gtccagtctg aaatgaaagg ggacagaagt cttgctgtcc atggtggtgt   2220

aggaatttct gtgcaacacc tcaccacgtc tggttaatcc ttgcacactt cagtgtttct   2280

ctcctgttca ataaaatgcc ctgttaagga tataatttg                          2319


<210>  9104
<211>  657
<212>  PRT
<213>  Homosapiens

<400>  9104

Met Gln Trp Arg Ala Leu Val Leu Gly Leu Val Leu Leu Arg Leu Gly 
1               5                   10                  15      


Leu His Gly Val Leu Trp Leu Val Phe Gly Leu Gly Pro Ser Met Gly 
            20                  25                  30          


Phe Tyr Gln Arg Phe Pro Leu Ser Phe Gly Phe Gln Arg Leu Arg Ser 
        35                  40                  45              


Pro Asp Gly Pro Ala Ser Pro Thr Ser Gly Pro Val Gly Arg Pro Gly 
    50                  55                  60                  


Gly Val Ser Gly Pro Ser Trp Leu Gln Pro Pro Gly Thr Gly Ala Ala 
65                  70                  75                  80  


Gln Ser Pro Arg Lys Ala Pro Arg Arg Pro Gly Pro Gly Met Cys Gly 
                85                  90                  95      


Pro Ala Asn Trp Gly Tyr Val Leu Gly Gly Arg Gly Arg Gly Pro Asp 
            100                 105                 110         


Glu Tyr Glu Lys Arg Tyr Ser Gly Ala Phe Pro Pro Gln Leu Arg Ala 
        115                 120                 125             


Gln Met Arg Asp Leu Ala Arg Gly Met Phe Val Phe Gly Tyr Asp Asn 
    130                 135                 140                 


Tyr Met Ala His Ala Phe Pro Gln Asp Glu Leu Asn Pro Ile His Cys 
145                 150                 155                 160 


Arg Gly Arg Gly Pro Asp Arg Gly Asp Pro Ser Asn Leu Asn Ile Asn 
                165                 170                 175     


Asp Val Leu Gly Asn Tyr Ser Leu Thr Leu Val Asp Ala Leu Asp Thr 
            180                 185                 190         


Leu Ala Ile Met Gly Asn Ser Ser Glu Phe Gln Lys Ala Val Lys Leu 
        195                 200                 205             


Val Ile Asn Thr Val Ser Phe Asp Lys Asp Ser Thr Val Gln Val Phe 
    210                 215                 220                 


Glu Ala Thr Ile Arg Val Leu Gly Ser Leu Leu Ser Ala His Arg Ile 
225                 230                 235                 240 


Ile Thr Asp Ser Lys Gln Pro Phe Gly Asp Met Thr Ile Lys Asp Tyr 
                245                 250                 255     


Asp Asn Glu Leu Leu Tyr Met Ala His Asp Leu Ala Val Arg Leu Leu 
            260                 265                 270         


Pro Ala Phe Glu Asn Thr Lys Thr Gly Ile Pro Tyr Pro Arg Val Asn 
        275                 280                 285             


Leu Lys Thr Gly Val Pro Pro Asp Thr Asn Asn Glu Thr Cys Thr Ala 
    290                 295                 300                 


Gly Ala Gly Ser Leu Leu Val Glu Phe Gly Ile Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Gly Asp Ser Thr Phe Glu Trp Val Ala Arg Arg Ala Val Lys Ala Leu 
                325                 330                 335     


Trp Asn Leu Arg Ser Asn Asp Thr Gly Leu Leu Gly Asn Val Val Asn 
            340                 345                 350         


Ile Gln Thr Gly His Trp Val Gly Lys Gln Ser Gly Leu Gly Ala Gly 
        355                 360                 365             


Leu Asp Ser Phe Tyr Glu Tyr Leu Leu Lys Ser Tyr Ile Leu Phe Gly 
    370                 375                 380                 


Glu Lys Glu Asp Leu Glu Met Phe Asn Ala Ala Tyr Gln Ser Ile Gln 
385                 390                 395                 400 


Asn Tyr Leu Arg Arg Gly Arg Glu Ala Cys Asn Glu Gly Glu Gly Asp 
                405                 410                 415     


Pro Pro Leu Tyr Val Asn Val Asn Met Phe Ser Gly Gln Leu Met Asn 
            420                 425                 430         


Thr Trp Ile Asp Ser Leu Gln Ala Phe Phe Pro Gly Leu Gln Val Leu 
        435                 440                 445             


Ile Gly Asp Val Glu Asp Ala Ile Cys Leu His Ala Phe Tyr Tyr Ala 
    450                 455                 460                 


Ile Trp Lys Arg Tyr Gly Ala Leu Pro Glu Arg Tyr Asn Trp Gln Leu 
465                 470                 475                 480 


Gln Ala Pro Asp Val Leu Phe Tyr Pro Leu Arg Pro Glu Leu Val Glu 
                485                 490                 495     


Ser Thr Tyr Leu Leu Tyr Gln Ala Thr Lys Asn Pro Phe Tyr Leu His 
            500                 505                 510         


Val Gly Met Asp Ile Leu Gln Ser Leu Glu Lys Tyr Thr Lys Val Lys 
        515                 520                 525             


Cys Gly Tyr Ala Thr Leu His His Val Ile Asp Lys Ser Thr Glu Asp 
    530                 535                 540                 


Arg Met Glu Ser Phe Phe Leu Ser Glu Thr Cys Lys Tyr Leu Tyr Leu 
545                 550                 555                 560 


Leu Phe Asp Glu Asp Asn Pro Val His Lys Ser Gly Thr Arg Tyr Met 
                565                 570                 575     


Phe Thr Thr Glu Gly His Ile Val Ser Val Asp Glu His Leu Arg Glu 
            580                 585                 590         


Leu Pro Trp Lys Glu Phe Phe Ser Glu Glu Gly Gly Gln Asp Gln Gly 
        595                 600                 605             


Gly Lys Ser Val His Arg Pro Lys Pro His Glu Leu Lys Val Ile Asn 
    610                 615                 620                 


Ser Ser Ser Asn Cys Asn Arg Val Pro Asp Glu Arg Arg Tyr Ser Leu 
625                 630                 635                 640 


Pro Leu Lys Ser Ile Tyr Met Arg Gln Ile Asp Gln Met Val Gly Leu 
                645                 650                 655     


Ile 
    


<210>  9105
<211>  766
<212>  DNA
<213>  Homosapiens

<400>  9105
gccgggctac ggggcgagcg cggggtgcgg tggtcggcgg ggaggccccc gcgctttaaa     60

ataatgcccg cggcgcccgc gcgaccatgc aatggcgagc gctcgtcctg gggctggtgc    120

tcctccggct tggcctccat ggagtattgt ggctcgtctt cgggctgggg cccagcatgg    180

gcttctacca gcgctttccg ctcagcttcg gcttccagcg tctgaggagc cccgacggcc    240

ccgcgtcgcc cacctcgggg cccgtgggcc ggcctggggg ggtatccggg ccgtcgtggc    300

tgcagccgcc ggggaccggg gcagcgcaga gcccgcgcaa ggctccgcgg cgtcctgggc    360

cggggatgtg cggcccagcc aactggggct acgtgctggg cggccggggc cgcggcccgg    420

acgagtacga gaagcgctac agcggcgcct tccctccgca gctgcgtgcc cagatgcgcg    480

acctggcacg gggcatgttc gtctttggct acgacaacta catggctcac gccttccccc    540

aggacgagct caaccccatc cactgccgcg gccgtgggcc cgaccgcggg gaccctttga    600

gagcatgatt tctaccgaag caaggggaca tcccaagcta aattcaaagg actgagcctt    660

ttcaaaattc taggaaaccg atgagttttt cttgcttaac catagcgttt atacgtataa    720

gtgtattttc tatctcaatt tttttgagaa aaaatattaa attttg                   766


<210>  9106
<211>  187
<212>  PRT
<213>  Homosapiens

<400>  9106

Met Ala Ser Ala Arg Pro Gly Ala Gly Ala Pro Pro Ala Trp Pro Pro 
1               5                   10                  15      


Trp Ser Ile Val Ala Arg Leu Arg Ala Gly Ala Gln His Gly Leu Leu 
            20                  25                  30          


Pro Ala Leu Ser Ala Gln Leu Arg Leu Pro Ala Ser Glu Glu Pro Arg 
        35                  40                  45              


Arg Pro Arg Val Ala His Leu Gly Ala Arg Gly Pro Ala Trp Gly Gly 
    50                  55                  60                  


Ile Arg Ala Val Val Ala Ala Ala Ala Gly Asp Arg Gly Ser Ala Glu 
65                  70                  75                  80  


Pro Ala Gln Gly Ser Ala Ala Ser Trp Ala Gly Asp Val Arg Pro Ser 
                85                  90                  95      


Gln Leu Gly Leu Arg Ala Gly Arg Pro Gly Pro Arg Pro Gly Arg Val 
            100                 105                 110         


Arg Glu Ala Leu Gln Arg Arg Leu Pro Ser Ala Ala Ala Cys Pro Asp 
        115                 120                 125             


Ala Arg Pro Gly Thr Gly His Val Arg Leu Trp Leu Arg Gln Leu His 
    130                 135                 140                 


Gly Ser Arg Leu Pro Pro Gly Arg Ala Gln Pro His Pro Leu Pro Arg 
145                 150                 155                 160 


Pro Trp Ala Arg Pro Arg Gly Pro Phe Glu Ser Met Ile Ser Thr Glu 
                165                 170                 175     


Ala Arg Gly His Pro Lys Leu Asn Ser Lys Asp 
            180                 185         


<210>  9107
<211>  445
<212>  DNA
<213>  Homosapiens

<400>  9107
agcatgttat agagtccaag gaatttgcca aatccgtgtg agaagatttg cctctcacat     60

gtgagagaat tttttgagaa aaaaaagatc ctgaccccgt ccctctgcca ccacccgagt    120

gaggaagact gacagagcac attggcttgc tgtggagaca agatcaggga aagcgcccct    180

gaaaagaaag cattttggaa gtcctgaagg tggagaagga gatttagagg aagagtgata    240

aatcagaagt cttcgtccaa gaattagctt tgcaccatct acagacctaa gcagctgcag    300

tcctggaact gtgtgataac ttgcccagaa aatcttcttg tggaatctgt ctttacatgg    360

aaaagacttg gcaatatttg tacagcaact ggaagaaagg tctttgctga gatatacaaa    420

gaggcagaat gtgtgtggat caccg                                          445


<210>  9108
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  9108

Leu Cys Thr Ile Tyr Arg Pro Lys Gln Leu Gln Ser Trp Asn Cys Val 
1               5                   10                  15      


Ile Thr Cys Pro Glu Asn Leu Leu Val Glu Ser Val Phe Thr Trp Lys 
            20                  25                  30          


Arg Leu Gly Asn Ile Cys Thr Ala Thr Gly Arg Lys Val Phe Ala Glu 
        35                  40                  45              


Ile Tyr Lys Glu Ala Glu Cys Val Trp Ile 
    50                  55              


<210>  9109
<211>  1334
<212>  DNA
<213>  Homosapiens

<400>  9109
gtagcaaggg acggaagctc tgcctgtgcg accgccgccc acccgagcct atctgggctg     60

cgtcttctcg ccgctgctct tcgtggccca acgccccaat ccttgcgtgt gcttgcagtc    120

ccaccccaca ctcagccttg tgtccctcga tccagtctcc gacttccatt tcccacccta    180

aaccgcctac ccggtgtctg ttccccgccc ggttgtcctc gccctgctgc gctgagtgtc    240

ccctgttagc ctcgacccca tggcgctgca gacgctgcag agctcgtggg tgaccttccg    300

caagatcctg tctcacttcc ccgaggagct gagtctggct ttcgtctacg gctccggggt    360

gtaccgccag gcagggccga gttcagacca gaagaatgct atgctggact ttgtgttcac    420

agtagatgac cctgtcgcat ggcattcaaa gaacctgaag aaaaattgga gtcactactc    480

tttcctaaaa gttttagggc ccaagattat cacgtccatc cagaataact atggcgctgg    540

agtttactac aattcattga tcatgtgtaa tggtaggctt atcaaatatg gagttattag    600

cactaacgtt ctgattgaag atctcctcaa ctggaataac ttatacattg ctggacgact    660

ccaaaaaccg gtgaaaatta tctcagtgaa cgaggatgtc actcttagat cagccctcga    720

tagaaatctg aagagtgctg tgaccgctgc tttcctcatg ctccccgaaa gcttttctga    780

agaagacctc ttcatagaga ttgccggtct ctcctattca ggtgactttc ggatggtggt    840

tggagaagat aaaacaaaag tgttgaatat tgtgaagccc aatatagccc actttcgaga    900

gctctatggc agcatactac aggaaaatcc tcaagtggtg tataaaagcc agcaaggctg    960

gctggagata gataaaagcc cagaaggaca gttcactcag ctgatgacat tgcccaaaac   1020

cttacagcaa cagataaatc atattatgga ccctcctgga aaaaacagag atgtggaaga   1080

aactttattc caagtggctc atgatcccga ctgtggagat gtggtgcgac tagggctttc   1140

agcaatcgtg agaccgtcta gtataagaca gagcacgaaa ggcattttta ctgctggcct   1200

gaagaagtca gtgatttata gttcactaaa actgcacaaa atgtggaaag ggtggctgag   1260

gaaaacatcc tgattttgct tgcttttata tatgttatgt gtagatgaat aaagtgtttg   1320

atcctttttg acag                                                     1334


<210>  9110
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  9110

Met Ala Leu Gln Thr Leu Gln Ser Ser Trp Val Thr Phe Arg Lys Ile 
1               5                   10                  15      


Leu Ser His Phe Pro Glu Glu Leu Ser Leu Ala Phe Val Tyr Gly Ser 
            20                  25                  30          


Gly Val Tyr Arg Gln Ala Gly Pro Ser Ser Asp Gln Lys Asn Ala Met 
        35                  40                  45              


Leu Asp Phe Val Phe Thr Val Asp Asp Pro Val Ala Trp His Ser Lys 
    50                  55                  60                  


Asn Leu Lys Lys Asn Trp Ser His Tyr Ser Phe Leu Lys Val Leu Gly 
65                  70                  75                  80  


Pro Lys Ile Ile Thr Ser Ile Gln Asn Asn Tyr Gly Ala Gly Val Tyr 
                85                  90                  95      


Tyr Asn Ser Leu Ile Met Cys Asn Gly Arg Leu Ile Lys Tyr Gly Val 
            100                 105                 110         


Ile Ser Thr Asn Val Leu Ile Glu Asp Leu Leu Asn Trp Asn Asn Leu 
        115                 120                 125             


Tyr Ile Ala Gly Arg Leu Gln Lys Pro Val Lys Ile Ile Ser Val Asn 
    130                 135                 140                 


Glu Asp Val Thr Leu Arg Ser Ala Leu Asp Arg Asn Leu Lys Ser Ala 
145                 150                 155                 160 


Val Thr Ala Ala Phe Leu Met Leu Pro Glu Ser Phe Ser Glu Glu Asp 
                165                 170                 175     


Leu Phe Ile Glu Ile Ala Gly Leu Ser Tyr Ser Gly Asp Phe Arg Met 
            180                 185                 190         


Val Val Gly Glu Asp Lys Thr Lys Val Leu Asn Ile Val Lys Pro Asn 
        195                 200                 205             


Ile Ala His Phe Arg Glu Leu Tyr Gly Ser Ile Leu Gln Glu Asn Pro 
    210                 215                 220                 


Gln Val Val Tyr Lys Ser Gln Gln Gly Trp Leu Glu Ile Asp Lys Ser 
225                 230                 235                 240 


Pro Glu Gly Gln Phe Thr Gln Leu Met Thr Leu Pro Lys Thr Leu Gln 
                245                 250                 255     


Gln Gln Ile Asn His Ile Met Asp Pro Pro Gly Lys Asn Arg Asp Val 
            260                 265                 270         


Glu Glu Thr Leu Phe Gln Val Ala His Asp Pro Asp Cys Gly Asp Val 
        275                 280                 285             


Val Arg Leu Gly Leu Ser Ala Ile Val Arg Pro Ser Ser Ile Arg Gln 
    290                 295                 300                 


Ser Thr Lys Gly Ile Phe Thr Ala Gly Leu Lys Lys Ser Val Ile Tyr 
305                 310                 315                 320 


Ser Ser Leu Lys Leu His Lys Met Trp Lys Gly Trp Leu Arg Lys Thr 
                325                 330                 335     


Ser 
    


<210>  9111
<211>  2931
<212>  DNA
<213>  Homosapiens

<400>  9111
acttaaatat aagtttattc taactaatcc caatatgtgg cctcaaaaca taagtccata     60

aatgtcattt ctaagattat tttacataaa tactcaaatt tgttgtcatt tttgtagcca    120

aagctaagta gaggatgggg cctgtgaatt tagaaccatc ctagtgataa atatcaaata    180

tttagataaa aacctaaata tttacccctc tagctttatg gagccattaa ataataacat    240

ttttctcctt ctcttcatag agtttataga caaaactaga aaattcaggt atttggtata    300

tacttttttg ttttttttga taccatcttg ctctgtggcc aggctggagt gcagtggcgt    360

gatctcggct cattgcaacc tccgcttccc gggctcaagc gattcccctg tcccagcctc    420

ctaagtagct gggactacag gcacatgcca ccacgcctgg ctaatttttt gtatttttag    480

tagagacggg gtttcaccat gttggccagg ttggtcttga tctcctgacc tcatggtctg    540

cccgcctcgg cctccctaag tgttgggatt atggctgtaa gccatgtcat ttcactctct    600

taatggtgtc ttttggtgaa aagaagttca taatttcatg tagtccagtt tatccatttt    660

gttttctata tgtttagcag ttttttgtgt cctgtttaga aaatttttgc ctattccaaa    720

atcatgaaat ttaagttctc cacctctgtt gaaattataa tattaaggca gaaaagactc    780

ttcattctga tctgttggtt cttagccttt tgcaagtcca ggatccctgt gaaaatctga    840

ctagaactct ggacgccctg cacagaagtg cacctacgca cacacacagt agattttcct    900

gcagtgttag ggagttcaca gacactcaga cttaatctgt ggaccccttg ttagagaacc    960

cctcatctat tccaacccag tcattttaca gataaggaaa ttgaggccca gggaaaggcc   1020

actgttagtt tgtggcccac ctggaactag agtccaggtc tcttgactcc gattctagtg   1080

ctctttctaa cagatttccc tgctgcagtc tttctgaaaa tgtctcactg gcagaaccat   1140

gaaagggaga atgttttagt caagggagat ttctgtccac tagcagcaac aaaaaaaaaa   1200

aatggctaca tggtgacact cttctacttt atgtatttac cttaaatgtt taagatccag   1260

gaactgcttt ttgaagttga gctgggaatt atcatggccc atgcatcctc ctctagctgt   1320

gactcagtgc cctggggttg ctatatgaac ctttccatgt ataactacct gtattcggct   1380

tggtcttttg gttggttctg gctggaattt taaaaaccac cttatataat aagcttctag   1440

tctcaatgct gaagtgggtg gggtttacca gagtggttgc tccagggaga aaattaaaag   1500

gggtggaggc agggaaagga actctgagtt tgttgactag gttatgttgg tttgcaagta   1560

gtcagctggt agacaaacga agccagagtg tctggaagta ttcattaatg attttactgc   1620

tcccctgcca ctgtctgcag tggtcttttc caaggctcta agtggactaa gcagtttaca   1680

ggtaacaggg ccagatattt tcaagccatc actcaaaccc cagtgctagg catgtccaga   1740

gcgaaacctg ttaccttgtc ggcatgctca ccaaagtgca ctgccagggg tgtgcacttt   1800

acactcatag cacagatcac agtttgtgtc tcacagtgaa aaagactgtt catatctttg   1860

ggccacaccc tgaaacacaa actgaatgat cccaccctca acacaaagga agttgagtcc   1920

ataatcgcat ccacagatag gatactctta gatctgacaa ataacaccca tttattttat   1980

tccctttttc ttctttcccc taagcccccg gagagccttt ctccagtttc atcacacact   2040

cctgactaag tagatggggg tgctaggggg ccagctctcc gaatgaggca catttgtctt   2100

gtcatttcaa aagctttcac agagcacctg ctgtgttctg ggtcctgtac taggtgacag   2160

ggccacctag gtgaacaggg caaggtccct gtcctcagga agctcccagt ccaggcagag   2220

gcgtgggtga atcggcccac acgtactgca cagtgtgttg agtgagcaca gatgctgtgg   2280

ggccaccctg tgggtccagg gaagcacttc ctagagaaga aatccaaaca gggattccaa   2340

gtcaacgagg cagaaagtga tgggaacagc atttgtcata gtcagacagg tgcctttcac   2400

agtgacatag agacagtgag gtggggttgg aatttaggcc tgagagaacg gggacccagt   2460

ggcatacaga gtcttatcct tgtcctacct ttttgaaaga gctaaattca gaggctgcca   2520

atatgttcat aactcaaaag gatcacttat cccaataact taggaaccgt tggcatccat   2580

agccctaaat cggaaaatgc cgaaatcaga atcatttccc cctacattga tcacagtgac   2640

ctttaatcac cttcagctcc ctggtctcct agagccacgg gtcagcccct cactgccctc   2700

ctccaaagac aagtctgctc agaatgtcac tgaaactctg agcatccact caacaagcct   2760

ccatcttctt actttctcat cttttctctt ttaggcctga agaagtcagt gatttatagt   2820

tcactaaaac tgcacaaaat gtggaaaggg tggctgagga aaacatcctg attttgcttg   2880

cttttatata tgttatgtgt agatgaataa agtgtttgat cctttttgac a            2931


<210>  9112
<211>  68
<212>  PRT
<213>  Homosapiens

<400>  9112

Met Glu Pro Leu Asn Asn Asn Ile Phe Leu Leu Leu Phe Ile Glu Phe 
1               5                   10                  15      


Ile Asp Lys Thr Arg Lys Phe Arg Tyr Leu Val Tyr Thr Phe Leu Phe 
            20                  25                  30          


Phe Leu Ile Pro Ser Cys Ser Val Ala Arg Leu Glu Cys Ser Gly Val 
        35                  40                  45              


Ile Ser Ala His Cys Asn Leu Arg Phe Pro Gly Ser Ser Asp Ser Pro 
    50                  55                  60                  


Val Pro Ala Ser 
65              


<210>  9113
<211>  1270
<212>  DNA
<213>  Homosapiens

<400>  9113
gtagcaaggg acggaagctc tgcctgtgcg accgccgccc acccgagcct atctgggctg     60

cgtcttctcg ccgctgctct tcgtggccca acgccccaat ccttgcgtgt gcttgcagtc    120

ccaccccaca ctcagccttg tgtccctcga tccagtctcc gacttccatt tcccacccta    180

aaccgcctac ccggtgtctg ttccccgccc ggttgtcctc gccctgctgc gctgagtgtc    240

ccctgttagc ctcgacccca tggcgctgca gacgctgcag agctcgtggg tgaccttccg    300

caagatcctg tctcacttcc ccgaggagct gagtctggct ttcgtctacg gctccggggt    360

gtaccgccag gcagggccga gttcagacca gaagaatgct atgctggact ttgtgttcac    420

agtagatgac cctgtcgcat ggcattcaaa gaacctgaag aaaaattgga gtcactactc    480

tttcctaaaa gttttagggc ccaagattat cacgtccatc cagaataact atggcgctgg    540

agtttactac aattcattga tcatgtgtaa tggtaggctt atcaaatatg gagttattag    600

cactaacgtt ctgattgaag atctcctcaa ctggaataac ttatacattg ctggacgact    660

ccaaaaaccg gtgaaaatta tctcagtgaa cgaggatgtc actcttagat cagccctcga    720

tagaaatctg aagagtgctg tgaccgctgc tttcctcatg ctccccgaaa gcttttctga    780

agaagacctc ttcatagaga ttgccggtct ctcctattca ggtgactttc ggatggtggt    840

tggagaagat aaaacaaaag tgttgaatat tgtgaagccc aatatagccc actttcgaga    900

gctctatggc agcatactac aggaaaatcc tcaagtggtg tataaaagcc agcaaggctg    960

gctggagata gataaaagcc cagaaggaca gttcactcag ctgatgacat tgcccaaaac   1020

cttacagcaa cagataaatc atattatgga ccctcctgga aaaaacagag atgtggaaga   1080

aactttattc caagtggctc atgatcccga ctgtggagat gtggtgcgac taggcctgaa   1140

gaagtcagtg atttatagtt cactaaaact gcacaaaatg tggaaagggt ggctgaggaa   1200

aacatcctga ttttgcttgc ttttatatat gttatgtgta gatgaataaa gtgtttgatc   1260

ctttttgaca                                                          1270


<210>  9114
<211>  316
<212>  PRT
<213>  Homosapiens

<400>  9114

Met Ala Leu Gln Thr Leu Gln Ser Ser Trp Val Thr Phe Arg Lys Ile 
1               5                   10                  15      


Leu Ser His Phe Pro Glu Glu Leu Ser Leu Ala Phe Val Tyr Gly Ser 
            20                  25                  30          


Gly Val Tyr Arg Gln Ala Gly Pro Ser Ser Asp Gln Lys Asn Ala Met 
        35                  40                  45              


Leu Asp Phe Val Phe Thr Val Asp Asp Pro Val Ala Trp His Ser Lys 
    50                  55                  60                  


Asn Leu Lys Lys Asn Trp Ser His Tyr Ser Phe Leu Lys Val Leu Gly 
65                  70                  75                  80  


Pro Lys Ile Ile Thr Ser Ile Gln Asn Asn Tyr Gly Ala Gly Val Tyr 
                85                  90                  95      


Tyr Asn Ser Leu Ile Met Cys Asn Gly Arg Leu Ile Lys Tyr Gly Val 
            100                 105                 110         


Ile Ser Thr Asn Val Leu Ile Glu Asp Leu Leu Asn Trp Asn Asn Leu 
        115                 120                 125             


Tyr Ile Ala Gly Arg Leu Gln Lys Pro Val Lys Ile Ile Ser Val Asn 
    130                 135                 140                 


Glu Asp Val Thr Leu Arg Ser Ala Leu Asp Arg Asn Leu Lys Ser Ala 
145                 150                 155                 160 


Val Thr Ala Ala Phe Leu Met Leu Pro Glu Ser Phe Ser Glu Glu Asp 
                165                 170                 175     


Leu Phe Ile Glu Ile Ala Gly Leu Ser Tyr Ser Gly Asp Phe Arg Met 
            180                 185                 190         


Val Val Gly Glu Asp Lys Thr Lys Val Leu Asn Ile Val Lys Pro Asn 
        195                 200                 205             


Ile Ala His Phe Arg Glu Leu Tyr Gly Ser Ile Leu Gln Glu Asn Pro 
    210                 215                 220                 


Gln Val Val Tyr Lys Ser Gln Gln Gly Trp Leu Glu Ile Asp Lys Ser 
225                 230                 235                 240 


Pro Glu Gly Gln Phe Thr Gln Leu Met Thr Leu Pro Lys Thr Leu Gln 
                245                 250                 255     


Gln Gln Ile Asn His Ile Met Asp Pro Pro Gly Lys Asn Arg Asp Val 
            260                 265                 270         


Glu Glu Thr Leu Phe Gln Val Ala His Asp Pro Asp Cys Gly Asp Val 
        275                 280                 285             


Val Arg Leu Gly Leu Lys Lys Ser Val Ile Tyr Ser Ser Leu Lys Leu 
    290                 295                 300                 


His Lys Met Trp Lys Gly Trp Leu Arg Lys Thr Ser 
305                 310                 315     


<210>  9115
<211>  742
<212>  DNA
<213>  Homosapiens

<400>  9115
ggtcatctca gtgcctggat ttgacgcggc ctccacgagt gtcaactgca gcaccacttc     60

ctttgactgc tggatttaag acaaatataa attttaaaac caaaagtcag aaattgatcc    120

ttgagagtgg cttctattct tttctcaggt agaaatggaa tattatagga caagaattgt    180

cctttttgaa gggacttaga ctcctgaaca cttacccatt cagtttcaga aaaagagagt    240

ttccttagct tgctgcctcg ccaggggtgt gggtgcatat atgtttgtgt gatttttaaa    300

gagaagccct gagttttgga gtatttgtag gatttaaagc acttccatag acgtcgtctt    360

ttttttcctc ccttcagata gataaaagcc cagaaggaca gttcactcag ctgatgacat    420

tgcccaaaac cttacagcaa cagataaatc atattatgga ccctcctgga aaaaacagag    480

atgtggaaga aactttattc caagtggctc atgatcccga ctgtggagat gtggtgcgac    540

tagggctttc agcaatcgtg agaccgtcta gtataagaca gagcacgaaa ggcattttta    600

ctgctggcct gaagaagtca gtgatttata gttcactaaa actgcacaaa atgtggaaag    660

ggtggctgag gaaaacatcc tgattttgct tgcttttata tatgttatgt gtagatgaat    720

aaagtgtttg atcctttttg ac                                             742


<210>  9116
<211>  89
<212>  PRT
<213>  Homosapiens

<400>  9116

Met Thr Leu Pro Lys Thr Leu Gln Gln Gln Ile Asn His Ile Met Asp 
1               5                   10                  15      


Pro Pro Gly Lys Asn Arg Asp Val Glu Glu Thr Leu Phe Gln Val Ala 
            20                  25                  30          


His Asp Pro Asp Cys Gly Asp Val Val Arg Leu Gly Leu Ser Ala Ile 
        35                  40                  45              


Val Arg Pro Ser Ser Ile Arg Gln Ser Thr Lys Gly Ile Phe Thr Ala 
    50                  55                  60                  


Gly Leu Lys Lys Ser Val Ile Tyr Ser Ser Leu Lys Leu His Lys Met 
65                  70                  75                  80  


Trp Lys Gly Trp Leu Arg Lys Thr Ser 
                85                  


<210>  9117
<211>  2780
<212>  DNA
<213>  Homosapiens

<400>  9117
gaaaatgaga atttaccaaa tttttaaatc atgtcacctg gtattttatc tttacactca     60

tgctttcaag tgaaaattcc agtgcattat tttcctcaag agaaagcagt ggcagataag    120

tactttctaa tttttttata tgtcactcaa gccgttggaa gcttcatagg taaagcataa    180

cttaaatata agtttattct aactaatccc aatatgtggc ctcaaaacat aagtccataa    240

atgtcatttc taagattatt ttacataaat actcaaattt gttgtcattt ttgtagccaa    300

agctaagtag aggatggggc ctgtgaattt agaaccatcc tagtgataaa tatcaaatat    360

ttagataaaa acctaaatat ttacccctct agctttatgg agccattaaa taataacatt    420

tttctccttc tcttcataga gtttatagac aaaactagaa aattcaggta tttggtatat    480

acttttttgt tttttttgat accatcttgg tcttgtcacc caggctgtag tgcagtggca    540

caatcaccac tcatcgtagc ctcaacttcc caggctcaag tgatcctccc acctcagcct    600

cccaagtaga cagaactgta ggcttgcacc accatgtctg gctttttttt gttttctttt    660

tttttttcgt agagccggat atctcactct tttgctaggg ctgatgttga atttttgtgc    720

tcaagcaatt ctcctgcctc agcctcccaa actgttggga ttacaggtgt gaacctgtgc    780

tcctggccca tttgatagat aaaagcccag aaggacagtt cactcagctg atgacattgc    840

ccaaaacctt acagcaacag ataaatcata ttatggaccc tcctggaaaa aacagagatg    900

tggaagaaac tttattccaa gtggctcatg atcccgactg tggagatgtg gtgcgactag    960

gtacgtttat gaatttgatg ttgaggaaat gccagccatg gggaaaagca gactttgttt   1020

gtgattggaa tgtattattt cttccttttt gtttagcgag atagagagat tgcctctcag   1080

aagaagaaag cactaaaaat ttgagggttt tctaaatctg catttttatt tgtttgaagt   1140

aagatggtga aaatacttct gtttttaaat tcctggatcc taaatcactg tcaaagggag   1200

aaacaatgtt tcttttggtt cctagagcac aacttctaga atttatttaa aagatgtgtc   1260

tgtgttttgt ggtggtctga gaaaagagat tggtggcatt tttttgtgct tttataacat   1320

cgagaacaca gctttcctca atcaactcca tttgatgtgt ctcatacatt gttgagtaca   1380

ttccctcaga catggcccac gttccacagc attttcccca gcactgccct gatgtttatc   1440

caaaactctg aacccaggcc aggtgcagtg gctcacgcct gtactcccaa cactttagga   1500

agtccaggag ggagaatcac ttgaggccag gagtttgaga ccagcttggg caacagagca   1560

agaccctgtc tctgcaaaaa ttacaaaagt agctgggcat ggtggcacat gcctataatc   1620

tcagctaact tgggagtctg aggtgggagg atcgcttgag cagttggagg ctgcaatgag   1680

ctaggatcgc accactacac tccaggcttg gtgatagagc agcccgtatc tcttaaaaaa   1740

caaacaaaaa aaagagcctg aaccttatct tcagagacta acttcccttt aaggtgctaa   1800

aggtaattta tgagatcagt caatcaagaa atatttatga aattgagaat gagtccctct   1860

gtcaattgag tgcattctcc tgttttcatt cagtaaatat ttactgagct cctccgcgtg   1920

ccagatagaa tttccagtaa tgctttgcaa agaccatcgc actgcagtgg atgagctgca   1980

gcaggcgctc cacgcccact ctcctcctgg gcctgcacta ggtttgcaga gtgtgtgttt   2040

aggtcaccag ctccccatcc tgaagatagc tctgtacgag gcacactgtt gtttgtttga   2100

acatgatcct ggcaacagtg tgatctgggc cgtctctttg aggtgagtga aacttgttcc   2160

tcactgtgga atccgtatgt gtgttttcag aatgaaagtt tttctcgtag atgtaatcat   2220

ttggttttta tcttttcatg ttatggaatt gagaaccaga aatctcaagc agatttaagt   2280

cataaaatgc cctttgaggg tcagctaacc catccccttg ttttaagggg aagaggcaca   2340

gagctgttcg gtcatcggct tggactcaca cagccgggtg gcgccacggc tggctgctct   2400

ggtctcctgg ccctcaatcc cactgccctt ttcattgtca ctgtgacagc aggacagaga   2460

tagatttggt ggtttgattg gctgactaga aagaatattt agtttcaagt tttaaaactg   2520

ttaagatgac taacatctgt tttgggtttt tttggtctcc tttttggttt ttttctcgca   2580

gggctttcag caatcgtgag accgtctagt ataagacaga gcacgaaagg catttttact   2640

gctggcctga agaagtcagt gatttatagt tcactaaaac tgcacaaaat gtggaaaggg   2700

tggctgagga aaacatcctg attttgcttg cttttatata tgttatgtgt agatgaataa   2760

agtgtttgat cctttttgac                                               2780


<210>  9118
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  9118

Met Thr Leu Pro Lys Thr Leu Gln Gln Gln Ile Asn His Ile Met Asp 
1               5                   10                  15      


Pro Pro Gly Lys Asn Arg Asp Val Glu Glu Thr Leu Phe Gln Val Ala 
            20                  25                  30          


His Asp Pro Asp Cys Gly Asp Val Val Arg Leu Gly Thr Phe Met Asn 
        35                  40                  45              


Leu Met Leu Arg Lys Cys Gln Pro Trp Gly Lys Ala Asp Phe Val Cys 
    50                  55                  60                  


Asp Trp Asn Val Leu Phe Leu Pro Phe Cys Leu Ala Arg 
65                  70                  75          


<210>  9119
<211>  2572
<212>  DNA
<213>  Homosapiens

<400>  9119
gtagcaaggg acggaagctc tgcctgtgcg accgccgccc acccgagcct atctgggctg     60

cgtcttctcg ccgctgctct tcgtggccca acgccccaat ccttgcgtgt gcttgcagtc    120

ccaccccaca ctcagccttg tgtccctcga tccagtctcc gacttccatt tcccacccta    180

aaccgcctac ccggtgtctg ttccccgccc ggttgtcctc gccctgctgc gctgagtgtc    240

ccctgttagc ctcgacccca tggcgctgca gacgctgcag agctcgtggg tgaccttccg    300

caagatcctg tctcacttcc ccgaggagct gagtctggct ttcgtctacg gctccggggt    360

gtaccgccag gcagggccga gttcagacca gaagaatgct atgctggact ttgtgttcac    420

agtagatgac cctgtcgcat ggcattcaaa gaacctgaag aaaaattgga gtcactactc    480

tttcctaaaa gttttagggc ccaagattat cacgtccatc cagaataact atggcgctgg    540

agtttactac aattcattga tcatgtgtaa tggtaggctt atcaaatatg gagttattag    600

cactaacgtt ctgattgaag atctcctcaa ctggaataac ttatacattg ctggacgact    660

ccaaaaaccg gcctctctgg cagtgtccca agagttcact ggcttttcac tctgaacaac    720

aaataacagt gctgctgaga caagttccta gttcaccttt cattgaagaa ccagatcagc    780

acagtagcag aatcttccga actgacattt ttcctttgag tgaaaattat ctcagtgaac    840

gaggatgtca ctcttagatc agccctcgat agaaatctga agagtgctgt gaccgctgct    900

ttcctcatgc tccccgaaag cttttctgaa gaagacctct tcatagagat tgccggtctc    960

tcctattcag gtgactttcg gatggtggtt ggagaagata aaacaaaagt gttgaatatt   1020

gtgaagccca atatagccca ctttcgagag ctctatggca gcatactaca ggaaaatcct   1080

caagtggtgt ataaaagcca gcaaggctgg ctggagatag ataaaagccc agaaggacag   1140

ttcactcagc tgatgacatt gcccaaaacc ttacagcaac agataaatca tattatggac   1200

cctcctggaa aaaacagaga tgtggaagaa actttattcc aagtggctca tgatcccgac   1260

tgtggagatg tggtgcgact aggtacgttt atgaatttga tgttgaggaa atgccagcca   1320

tggggaaaag cagactttgt ttgtgattgg aatgtattat ttcttccttt ttgtttagcg   1380

agatagagag attgcctctc agaagaagaa agcactaaaa atttgagggt tttctaaatc   1440

tgcattttta tttgtttgaa gtaagatggt gaaaatactt ctgtttttaa attcctggat   1500

cctaaatcac tgtcaaaggg agaaacaatg tttcttttgg ttcctagagc acaacttcta   1560

gaatttattt aaaagatgtg tctgtgtttt gtggtggtct gagaaaagag attggtggca   1620

tttttttgtg cttttataac atcgagaaca cagctttcct caatcaactc catttgatgt   1680

gtctcataca ttgttgagta cattccctca gacatggccc acgttccaca gcattttccc   1740

cagcactgcc ctgatgttta tccaaaactc tgaacccagg ccaggtgcag tggctcacgc   1800

ctgtactccc aacactttag gaagtccagg agggagaatc acttgaggcc aggagtttga   1860

gaccagcttg ggcaacagag caagaccctg tctctgcaaa aattacaaaa gtagctgggc   1920

atggtggcac atgcctataa tctcagctaa cttgggagtc tgaggtggga ggatcgcttg   1980

agcagttgga ggctgcaatg agctaggatc gcaccactac actccaggct tggtgataga   2040

gcagcccgta tctcttaaaa aacaaacaaa aaaaagagcc tgaaccttat cttcagagac   2100

taacttccct ttaaggtgct aaagtaaata tttactgagc tcctccgcgt gccagataga   2160

atttccagta atgctttgca aagaccatcg cactgcagtg gatgagctgc agcaggcgct   2220

ccacgcccac tctcctcctg ggcctgcact aggtttgcag agtgtgtgtt taggtcacca   2280

gctccccatc ctgaagatag ctctgtacga ggcacactgt tgtttgtttg aacatgatcc   2340

tggcaacagt gtgatctggg ccgtctcttt gagggctttc agcaatcgtg agaccgtcta   2400

gtataagaca gagcacgaaa ggcattttta ctgctggcct gaagaagtca gtgatttata   2460

gttcactaaa actgcacaaa atgtggaaag ggtggctgag gaaaacatcc tgattttgct   2520

tgcttttata tatgttatgt gtagatgaat aaagtgtttg atcctttttg ac           2572


<210>  9120
<211>  159
<212>  PRT
<213>  Homosapiens

<400>  9120

Met Leu Pro Glu Ser Phe Ser Glu Glu Asp Leu Phe Ile Glu Ile Ala 
1               5                   10                  15      


Gly Leu Ser Tyr Ser Gly Asp Phe Arg Met Val Val Gly Glu Asp Lys 
            20                  25                  30          


Thr Lys Val Leu Asn Ile Val Lys Pro Asn Ile Ala His Phe Arg Glu 
        35                  40                  45              


Leu Tyr Gly Ser Ile Leu Gln Glu Asn Pro Gln Val Val Tyr Lys Ser 
    50                  55                  60                  


Gln Gln Gly Trp Leu Glu Ile Asp Lys Ser Pro Glu Gly Gln Phe Thr 
65                  70                  75                  80  


Gln Leu Met Thr Leu Pro Lys Thr Leu Gln Gln Gln Ile Asn His Ile 
                85                  90                  95      


Met Asp Pro Pro Gly Lys Asn Arg Asp Val Glu Glu Thr Leu Phe Gln 
            100                 105                 110         


Val Ala His Asp Pro Asp Cys Gly Asp Val Val Arg Leu Gly Thr Phe 
        115                 120                 125             


Met Asn Leu Met Leu Arg Lys Cys Gln Pro Trp Gly Lys Ala Asp Phe 
    130                 135                 140                 


Val Cys Asp Trp Asn Val Leu Phe Leu Pro Phe Cys Leu Ala Arg 
145                 150                 155                 


<210>  9121
<211>  535
<212>  DNA
<213>  Homosapiens

<400>  9121
tactccactt ctggaatttt tcttcccaat gttctgcttc tttcaggtga aaattatctc     60

agtgaacgag gatgtcactc ttagatcagc cctcgataga aatctgaaga gtgctgtgac    120

cgctgctttc ctcatgctcc ccgaaagctt ttctgaagaa gacctcttca tagagattgc    180

cggtctctcc tattcagatg agaaaactga ggcccagaat ggttccctgt ctaaggtcac    240

tcatctggta catggtggac tagtttgaat accagctttc taaaggtgac tttcggatgg    300

tggttggaga agataaaaca aaagtgttga atattgtgaa gcccaatata gcccactttc    360

gagagctcta tggcagcata ctacaggaaa atcctcaagt ggtgtataaa agccagcaag    420

gctggctgga ggtaactgta tgtggaaaat agcttgtatt gtttctaaga caaaggctat    480

ttgcaggaag aaagtcaggg gtagaacagc atgactggtg tgagaacatt tatag         535


<210>  9122
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  9122

Met Phe Cys Phe Phe Gln Val Lys Ile Ile Ser Val Asn Glu Asp Val 
1               5                   10                  15      


Thr Leu Arg Ser Ala Leu Asp Arg Asn Leu Lys Ser Ala Val Thr Ala 
            20                  25                  30          


Ala Phe Leu Met Leu Pro Glu Ser Phe Ser Glu Glu Asp Leu Phe Ile 
        35                  40                  45              


Glu Ile Ala Gly Leu Ser Tyr Ser Asp Glu Lys Thr Glu Ala Gln Asn 
    50                  55                  60                  


Gly Ser Leu Ser Lys Val Thr His Leu Val His Gly Gly Leu Val 
65                  70                  75                  


<210>  9123
<211>  881
<212>  DNA
<213>  Homosapiens

<400>  9123
gtagcaaggg acggaagctc tgcctgtgcg accgccgccc acccgagcct atctgggctg     60

cgtcttctcg ccgctgctct tcgtggccca acgccccaat ccttgcgtgt gcttgcagtc    120

ccaccccaca ctcagccttg tgtccctcga tccagtctcc gacttccatt tcccacccta    180

aaccgcctac ccggtgtctg ttccccgccc ggttgtcctc gccctgctgc gctgagtgtc    240

ccctgttagc ctcgacccca tggcgctgca gacgctgcag agctcgtggg tgaccttccg    300

caagatcctg tctcacttcc ccgaggagct gagtctggct ttcgtctacg gctccggggt    360

gtaccgccag gcagggccga gttcagacca gaagaatgct atgctggact ttgtgttcac    420

agtagatgac cctgtcgcat ggcattcaaa gaacctgaag aaaaattgga gtcactactc    480

tttcctaaaa gttttagggc ccaagattat cacgtccatc cagaataact atggcgctgg    540

agtttactac aattcattga tcatgtgtaa tggtaggctt atcaaatatg gagttattag    600

cactaacgtt ctgattgaag atctcctcaa ctggaataac ttatacattg ctggacgact    660

ccaaaaaccg gcctctctgg cagtgtccca agagttcact ggcttttcac tctgaacaac    720

aaataacagt gctgctgaga caagttccta gttcaccttt cattgaagaa ccagatcagc    780

acagtagcag aatcttccga actgacattt ttcctttgag gtctcaactg tgtctttcag    840

gctggagtgt agtgtcatga tcatggctca ctgcaaccca c                        881


<210>  9124
<211>  151
<212>  PRT
<213>  Homosapiens

<400>  9124

Met Ala Leu Gln Thr Leu Gln Ser Ser Trp Val Thr Phe Arg Lys Ile 
1               5                   10                  15      


Leu Ser His Phe Pro Glu Glu Leu Ser Leu Ala Phe Val Tyr Gly Ser 
            20                  25                  30          


Gly Val Tyr Arg Gln Ala Gly Pro Ser Ser Asp Gln Lys Asn Ala Met 
        35                  40                  45              


Leu Asp Phe Val Phe Thr Val Asp Asp Pro Val Ala Trp His Ser Lys 
    50                  55                  60                  


Asn Leu Lys Lys Asn Trp Ser His Tyr Ser Phe Leu Lys Val Leu Gly 
65                  70                  75                  80  


Pro Lys Ile Ile Thr Ser Ile Gln Asn Asn Tyr Gly Ala Gly Val Tyr 
                85                  90                  95      


Tyr Asn Ser Leu Ile Met Cys Asn Gly Arg Leu Ile Lys Tyr Gly Val 
            100                 105                 110         


Ile Ser Thr Asn Val Leu Ile Glu Asp Leu Leu Asn Trp Asn Asn Leu 
        115                 120                 125             


Tyr Ile Ala Gly Arg Leu Gln Lys Pro Ala Ser Leu Ala Val Ser Gln 
    130                 135                 140                 


Glu Phe Thr Gly Phe Ser Leu 
145                 150     


<210>  9125
<211>  978
<212>  DNA
<213>  Homosapiens

<400>  9125
ccgcccaccc gagcctatct gggctgcgtc ttctcgccgc tgctcttcgt ggcccaacgc     60

cccaatcctt gcgtgtgctt gcagtcccac cccacactca gccttgtgtc cctcgatcca    120

gtctccgact tccatttccc accctaaacc gcctacccgg tgtctgttcc ccgcccggtt    180

gtcctcgccc tgctgcgctg agtgtcccct gttagcctcg accccatggc gctgcagacg    240

ctgcagagct cgtgggtgac cttccgcaag atcctgtctc acttccccga ggagctgagt    300

ctggctttcg tctacggctc cggggtgtac cgccaggcag ggccgagttc agaccagaag    360

aatgctatgc tggactttgt gttcacagta gatgaccctg tcgcatggca ttcaaagaac    420

ctgaagaaaa attggagtca ctactctttc ctaaaagttt tagggcccaa gattatcacg    480

tccatccaga ataactatgg cgctggagtt tactacaatt cattgatcat gtgtaatggt    540

agggtaagtg actgctggcc tttgtcttaa cttggctggt tatttacctg ggttattaga    600

gtgccagcta aatatgtatg ttcttgtggt caggaaacat tcacactcct gctggacgtt    660

gttatagtcg ggaaatatgt atgtttttat agtatgtata ttcttatagt caggaaacat    720

tcacactcct gccagacgtc ttgaacttgg ggacagagca gggactggag tccttcctca    780

tgtcccatta actgtcattg cagtgtgagg aggtggttgg gtgtgactga cttattttat    840

tttttttatt tttttgagac ggagttttgc tcttgttgcc caggctggag tgcagtggtg    900

tgatcgcagc tcactgcaac ctccgcctca cgggttcaag tgattctccc gcctcagcct    960

cccagttagc tgggatta                                                  978


<210>  9126
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  9126

Met Ala Leu Gln Thr Leu Gln Ser Ser Trp Val Thr Phe Arg Lys Ile 
1               5                   10                  15      


Leu Ser His Phe Pro Glu Glu Leu Ser Leu Ala Phe Val Tyr Gly Ser 
            20                  25                  30          


Gly Val Tyr Arg Gln Ala Gly Pro Ser Ser Asp Gln Lys Asn Ala Met 
        35                  40                  45              


Leu Asp Phe Val Phe Thr Val Asp Asp Pro Val Ala Trp His Ser Lys 
    50                  55                  60                  


Asn Leu Lys Lys Asn Trp Ser His Tyr Ser Phe Leu Lys Val Leu Gly 
65                  70                  75                  80  


Pro Lys Ile Ile Thr Ser Ile Gln Asn Asn Tyr Gly Ala Gly Val Tyr 
                85                  90                  95      


Tyr Asn Ser Leu Ile Met Cys Asn Gly Arg Val Ser Asp Cys Trp Pro 
            100                 105                 110         


Leu Ser 
        


<210>  9127
<211>  2490
<212>  DNA
<213>  Homosapiens

<400>  9127
agaccgccgc tgctgtctgc ggggtctggt gccggggcct gagtctctgc tggctaagcc     60

gacgcctcag ccgcctcagt cgcctcaatc tcgccttccg ccctcgctct ccctccgcgc    120

caccggaccc cgtagccccg cgcgccccca gacctttaag ccagatgatg aacttcctgc    180

ggcgccggct gtcggacaca gcttattcag ctcgctgtcc caagcggtaa agcagacggc    240

cgcctcggct ggcctggtgg acgcgcccgg tgccgcgccg gcagccgcca ggaaggccaa    300

ggtgctgctg gtggtcgacg agccgcacgc cgactgggcc aagtgctttc ggggcaaaaa    360

agtccttgga gattatgata tcaaggtgga acaggcagaa ttttcagagc tcaacctggt    420

ggcccatgca gatggcacct atgctgtgga tatgcaggtt ctccggaatg gcacaaaggt    480

tgtccggtcc ttccggccag acttcgtgct catccggcag catgcatttg gcatggcgga    540

gaatgaggac ttccgccacc tgatcattgg tatgcagtat gcaggcctcc ccagcatcaa    600

ctcactggaa tccatataca acttctgtga caagccatgg gtgtttgccc agctggtcgc    660

tatctataag acactgggag gagaaaagtt ccctctcatt gaacagacat actaccccaa    720

ccacaaagag atgctgacac tgcccacgtt ccctgtggtg gtgaagattg gccacgctca    780

ctcaggcatg ggcaaggtca aagtggaaaa ccactacgac ttccaggaca ttgccagcgt    840

ggtggctctc acccagacct atgccactgc agagcctttc attgactcca agtatgacat    900

ccgggtccag aagattggca acaactacaa ggcttacatg aggacatcga tctcagggaa    960

ctggaagacg aacactggct ctgcgatgct ggagcagatt gccatgtcag acaggtacaa   1020

actgtgggtg gacacctgct ctgagatgtt tggcggcctg gacatctgtg ctgtcaaagc   1080

tgtacatggc aaagatggga aagactacat ttttgaggtc atggactgta gcatgccact   1140

gattggggaa catcaggtgg aggacaggca actcatcacc gaactagtca tcagcaagat   1200

gaaccagctg ctgtccagga ctcctgccct gtctcctcag agacccctaa caacccagca   1260

gccacagagc ggaacactta aggatccgga ctcaagcaag accccacctc agcggccacc   1320

ccctcaaggg ggccctgggc aaccccaagg aatgcagccc ccaggcaagg tgctgcctcc   1380

acgccggctc ccccctggac catcactgcc accttcctcc tcttcctcct cttcttcctc   1440

ctcctcggct cctcagcggc cgggcggccc caccacccac ggagatgcac cctccagcag   1500

cagctccctg gcagaggccc agccacccct ggctgctcca ccacagaagc cccagcctca   1560

cccacagctc aacaagtcgc agtccctgac aaatgccttc agcttctctg agtcctcctt   1620

cttccggtct tcagccaatg aggatgaagc caaagcagag accatccgga gcttgaggaa   1680

gtcctttgcc agcctctttt cagattagct cttcagacac acggggcacc cagcccaacc   1740

gggaaaggca tctaagacat tcaccaacaa cagtcagcca gcttggtggt tatgtcccat   1800

gaccttgacg tgtgtggtcc cttcctctgc tctgttgtac taagtgatgt tgtgcagccc   1860

agaaaggacc atttgacagt ctcagggcag gtgcctaccc agcaaggggt acctggcatc   1920

agagaggaaa gagctgcttc cctgtagtca tgagagcttc cttctgaagt catcgttcgc   1980

tgtgagttta gtggccttat tgtgacagtg ccatcatgtc ttattcttcc ctgtgaaacc   2040

aggattaatc gtggactcct ggcagcttaa cctagctcag ttgcagtgct aagcatgccc   2100

cgcccccatt cagtgatacc tgtttgggaa gtatatactt ccccaaaagt actcttggcc   2160

ctaagtttta ggaactttcc ccgacctgga tcccttgtca tacctgtgtt actgtttaaa   2220

gcacacccac ccaacttaca agatcttagg ctgctgtggt ggtgaagcac cttgagtctg   2280

ctgatattcg ggagaacaag gatctgcagt ttcccctttt ctcccctctg aagagtggtt   2340

cttatgtgca atctgcagta accttgaact ccagagctgc actatagagg agaatgcatg   2400

ccactatgac agcagtatgc caagctttgt gttcatctcc taataaacgt taagaccttt   2460

ggtgtaataa aagcagcagc attcaccaac                                    2490


<210>  9128
<211>  418
<212>  PRT
<213>  Homosapiens

<400>  9128

Met Gln Val Leu Arg Asn Gly Thr Lys Val Val Arg Ser Phe Arg Pro 
1               5                   10                  15      


Asp Phe Val Leu Ile Arg Gln His Ala Phe Gly Met Ala Glu Asn Glu 
            20                  25                  30          


Asp Phe Arg His Leu Ile Ile Gly Met Gln Tyr Ala Gly Leu Pro Ser 
        35                  40                  45              


Ile Asn Ser Leu Glu Ser Ile Tyr Asn Phe Cys Asp Lys Pro Trp Val 
    50                  55                  60                  


Phe Ala Gln Leu Val Ala Ile Tyr Lys Thr Leu Gly Gly Glu Lys Phe 
65                  70                  75                  80  


Pro Leu Ile Glu Gln Thr Tyr Tyr Pro Asn His Lys Glu Met Leu Thr 
                85                  90                  95      


Leu Pro Thr Phe Pro Val Val Val Lys Ile Gly His Ala His Ser Gly 
            100                 105                 110         


Met Gly Lys Val Lys Val Glu Asn His Tyr Asp Phe Gln Asp Ile Ala 
        115                 120                 125             


Ser Val Val Ala Leu Thr Gln Thr Tyr Ala Thr Ala Glu Pro Phe Ile 
    130                 135                 140                 


Asp Ser Lys Tyr Asp Ile Arg Val Gln Lys Ile Gly Asn Asn Tyr Lys 
145                 150                 155                 160 


Ala Tyr Met Arg Thr Ser Ile Ser Gly Asn Trp Lys Thr Asn Thr Gly 
                165                 170                 175     


Ser Ala Met Leu Glu Gln Ile Ala Met Ser Asp Arg Tyr Lys Leu Trp 
            180                 185                 190         


Val Asp Thr Cys Ser Glu Met Phe Gly Gly Leu Asp Ile Cys Ala Val 
        195                 200                 205             


Lys Ala Val His Gly Lys Asp Gly Lys Asp Tyr Ile Phe Glu Val Met 
    210                 215                 220                 


Asp Cys Ser Met Pro Leu Ile Gly Glu His Gln Val Glu Asp Arg Gln 
225                 230                 235                 240 


Leu Ile Thr Glu Leu Val Ile Ser Lys Met Asn Gln Leu Leu Ser Arg 
                245                 250                 255     


Thr Pro Ala Leu Ser Pro Gln Arg Pro Leu Thr Thr Gln Gln Pro Gln 
            260                 265                 270         


Ser Gly Thr Leu Lys Asp Pro Asp Ser Ser Lys Thr Pro Pro Gln Arg 
        275                 280                 285             


Pro Pro Pro Gln Gly Gly Pro Gly Gln Pro Gln Gly Met Gln Pro Pro 
    290                 295                 300                 


Gly Lys Val Leu Pro Pro Arg Arg Leu Pro Pro Gly Pro Ser Leu Pro 
305                 310                 315                 320 


Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Pro Gln Arg 
                325                 330                 335     


Pro Gly Gly Pro Thr Thr His Gly Asp Ala Pro Ser Ser Ser Ser Ser 
            340                 345                 350         


Leu Ala Glu Ala Gln Pro Pro Leu Ala Ala Pro Pro Gln Lys Pro Gln 
        355                 360                 365             


Pro His Pro Gln Leu Asn Lys Ser Gln Ser Leu Thr Asn Ala Phe Ser 
    370                 375                 380                 


Phe Ser Glu Ser Ser Phe Phe Arg Ser Ser Ala Asn Glu Asp Glu Ala 
385                 390                 395                 400 


Lys Ala Glu Thr Ile Arg Ser Leu Arg Lys Ser Phe Ala Ser Leu Phe 
                405                 410                 415     


Ser Asp 
        


<210>  9129
<211>  3912
<212>  DNA
<213>  Homosapiens

<400>  9129
ccgccgctgc tgtctgcggg gtctggtgcc ggggcctgag tctctgctgg ctaagccgac     60

gcctcagccg cctcagtcgc ctcaatctcg ccttccgccc tcgctctccc tccgcgccac    120

cggaccccgt agccccgcgc gcccccagac ctttaagcca gatgatgaac ttcctgcggc    180

gccggctgtc ggacagcagc ttcatcgcca atctgcccaa cggctacatg accgacctgc    240

agcggcccga gccccagcaa gcgccgacgc cgccgccccc cggcccgggc gccgcctcgg    300

cctaggcggc gcccccgacc gcctcgccgg gaccggagcg gacgccgccg gccgcctagg    360

cgcccgcgcc gtaagacgcg ccgaagaccg cgcccccccc cccgcgcgaa caccgtcggt    420

gggcagcagc ttattcagct cgctgtccca agcggtaaag cagacggccg cctcggctgg    480

cctggtggac gcgcccggtg ccgcgccggc agccgccagg aaggccaagg tgctgctggt    540

ggtcgacgag ccgcacgccg actgggccaa gtgctttcgg ggcaaaaaag tccttggaga    600

ttatgatatc aaggtggaac aggcagaatt ttcagagctc aacctggtgg cccatgcaga    660

tggcacctat gctgtggata tgcaggttct ccggaatggc acaaaggttg tccggtcctt    720

ccggccagac ttcgtgctca tccggcagca tgcatttggc atggcggaga atgaggactt    780

ccgccacctg atcattggta tgcagtatgc aggcctcccc agcatcaact cactggaatc    840

catatacaac ttctgtgaca agccatgggt gtttgcccag ctggtcgcta tctataagac    900

actgggagga gaaaagttcc ctctcattga acagacatac taccccaacc acaaagagat    960

gctgacactg cccacgttcc ctgtggtggt gaagattggc cacgctcact caggcatggg   1020

caaggtcaaa gtggaaaacc actacgactt ccaggacatt gccagcgtgg tggctctcac   1080

ccagacctat gccactgcag agcctttcat tgactccaag tatgacatcc gggtccagaa   1140

gattggcaac aactacaagg cttacatgag gacatcgatc tcagggaact ggaagacgaa   1200

cactggctct gcgatgctgg agcagattgc catgtcagac aggtacaaac tgtgggtgga   1260

cacctgctct gagatgtttg gcggcctgga catctgtgct gtcaaagctg tacatggcaa   1320

agatgggaaa gactacattt ttgaggtcat ggactgtagc atgccactga ttggggaaca   1380

tcaggtggag gacaggcaac tcatcaccga actagtcatc agcaagatga accagctgct   1440

gtccaggact cctgccctgt ctcctcagag acccctaaca acccagcagc cacagagcgg   1500

aacacttaag gatccggact caagcaagac cccacctcag cggccacccc ctcaaggttg   1560

tttacagtat attctcgact gtaatggcat tgcagtaggg ccaaaacaag tccaagcttc   1620

ttaaaatgat tggtggttaa tttttcaaag cagaaatttt aagccaaaaa caaacgaaag   1680

gaaagcgggg aggggaaaac agaccctccc actggtgccg ttgctgcgtt ctttcaatgc   1740

tgactggact gtgtttttcc tatgcagtgt cagctcctct gtctggttgt ttacctgttc   1800

ctgttcgtgc ttgtaatgct cacttatgtt ttctctgtat aacttgtgat tccagggctg   1860

tttgtcaaca gtatacaaaa gaattgtgcc tctcccaagt ccagtgtgac tttatcttct   1920

gggtggtttg atagtgtttt taaaagtaat atataatgtg gggtgaaatg ggagtagggg   1980

ggtggacagg ggagaaacga aaaccacaaa aagaaaaccc aactcctctc ctccccccaa   2040

gctcagttaa atcccccacc tccaactttc cctccaccag tgtgcttggg atcttcaatg   2100

aactgtgctt ttcgctttct ttctgcatga ctattgtaac tagatagaac attaagagat   2160

tttcaagatc aaacttccat agcttcatcc actgaatttg aaggcatcca cctttttctc   2220

catttgctaa aatttggtgc agtttgagtt tatgtgaata ggctggctgt gcctgtagag   2280

ctcttgtgtt tttagtgatg acatgaaata caaagaacaa gctatttcca ggaatgtgtt   2340

ctgtatttta catcccagtg taccctttat tttattatta actaattaac tatgagattt   2400

ttaaaaaatg gggccgctga tgtgcaatat caaagtgaac ttgtgagtat tttgtgtgtg   2460

ttgatctcag ttgtttcttc attgttgctg tttctggatc cagccatgtg tgcgcttgtg   2520

tggacctgag gctgctttct gttcccaaag cttgacctgt gtacagagat aattccttgg   2580

caatgttgga catagaatgc agggagctac tgaaggtctg tcagggattt gtccattctg   2640

ctcttggcct ctcctgaggc ctcataatgg gagaccaaat caaaaatgtc ccatgtcact   2700

tgagtgggta cactgcctac agaaccttga ggttgactcc tgcttcagtt ctcagctgtt   2760

taccacagcc ctccagggtc caaagattga ggagctttct ctttcctggg aggaactgtc   2820

tcagatttag cttgtgtgtg ttttggacag aggctccaca gcggtggctc ttgaggaatc   2880

ctcaccagtt tgttctcttc cctctgacaa gcagcacctg agcagatgct gaggcagttc   2940

attaaaccag gcctcagctt cagtgcctca tcttgccatc tcccggccag gctgggaacg   3000

ggcaccaagc agccgcctct aacaaacacc atggtccgtg gaagttcatg ccagcagctt   3060

gcctttgaga agaaatgctg ctggctctat ttttacattc ccttccacct ctatactgtc   3120

atgtcaccgt tctgaactcc cagatctgag aaggaactag tgttggtggt atgtaacaag   3180

agttacgtat ccaggggctt gtgccttggt ttctcctttg attgctggta aattctgagg   3240

ccacagagaa atgcattgag tgtgaatgtt gtcatctgta atccctccct cagctgataa   3300

tggtagttga tctgttgtaa atatatacat atatgcatat ttgcacttcc agatgggttg   3360

cataagaatc aggtccttaa atacctccca atctgatgaa acgatagaat aaagtaacat   3420

ttcccagaat ggaggaatac attattttat cgtatatttt tgtccaagcg atgagctgac   3480

ggtggtattg cttctctgca tgttatcagt gtgtacatct ggtgcttttc atgtgtcatt   3540

tgtgagccac aaatgcaaag ttgccatttg aattcagtca ggctacaggg tggtgtcagt   3600

caaggtcttt caggtggggg agaaattggt tagggctccc actgccaaat gcaagcagat   3660

agcataacct gactgttatg tgccctcagg cagcatgctt agggacaact ctgtggcctg   3720

ggggacatct gtgtcacagt ataggattgc cattcaggtg ttttgtacct atttctttcc   3780

tgacgttgtc cccttttttt gtactgatcc aactgggaga acctcagcca atgctggaag   3840

tatgattgaa gtacctctct tttgtgactc ttgtacagct taatgtgcaa taaaggaaaa   3900

gttatatctg tc                                                       3912


<210>  9130
<211>  314
<212>  PRT
<213>  Homosapiens

<400>  9130

Met Gln Val Leu Arg Asn Gly Thr Lys Val Val Arg Ser Phe Arg Pro 
1               5                   10                  15      


Asp Phe Val Leu Ile Arg Gln His Ala Phe Gly Met Ala Glu Asn Glu 
            20                  25                  30          


Asp Phe Arg His Leu Ile Ile Gly Met Gln Tyr Ala Gly Leu Pro Ser 
        35                  40                  45              


Ile Asn Ser Leu Glu Ser Ile Tyr Asn Phe Cys Asp Lys Pro Trp Val 
    50                  55                  60                  


Phe Ala Gln Leu Val Ala Ile Tyr Lys Thr Leu Gly Gly Glu Lys Phe 
65                  70                  75                  80  


Pro Leu Ile Glu Gln Thr Tyr Tyr Pro Asn His Lys Glu Met Leu Thr 
                85                  90                  95      


Leu Pro Thr Phe Pro Val Val Val Lys Ile Gly His Ala His Ser Gly 
            100                 105                 110         


Met Gly Lys Val Lys Val Glu Asn His Tyr Asp Phe Gln Asp Ile Ala 
        115                 120                 125             


Ser Val Val Ala Leu Thr Gln Thr Tyr Ala Thr Ala Glu Pro Phe Ile 
    130                 135                 140                 


Asp Ser Lys Tyr Asp Ile Arg Val Gln Lys Ile Gly Asn Asn Tyr Lys 
145                 150                 155                 160 


Ala Tyr Met Arg Thr Ser Ile Ser Gly Asn Trp Lys Thr Asn Thr Gly 
                165                 170                 175     


Ser Ala Met Leu Glu Gln Ile Ala Met Ser Asp Arg Tyr Lys Leu Trp 
            180                 185                 190         


Val Asp Thr Cys Ser Glu Met Phe Gly Gly Leu Asp Ile Cys Ala Val 
        195                 200                 205             


Lys Ala Val His Gly Lys Asp Gly Lys Asp Tyr Ile Phe Glu Val Met 
    210                 215                 220                 


Asp Cys Ser Met Pro Leu Ile Gly Glu His Gln Val Glu Asp Arg Gln 
225                 230                 235                 240 


Leu Ile Thr Glu Leu Val Ile Ser Lys Met Asn Gln Leu Leu Ser Arg 
                245                 250                 255     


Thr Pro Ala Leu Ser Pro Gln Arg Pro Leu Thr Thr Gln Gln Pro Gln 
            260                 265                 270         


Ser Gly Thr Leu Lys Asp Pro Asp Ser Ser Lys Thr Pro Pro Gln Arg 
        275                 280                 285             


Pro Pro Pro Gln Gly Cys Leu Gln Tyr Ile Leu Asp Cys Asn Gly Ile 
    290                 295                 300                 


Ala Val Gly Pro Lys Gln Val Gln Ala Ser 
305                 310                 


<210>  9131
<211>  2696
<212>  DNA
<213>  Homosapiens

<400>  9131
ccgccgctgc tgtctgcggg gtctggtgcc ggggcctgag tctctgctgg ctaagccgac     60

gcctcagccg cctcagtcgc ctcaatctcg ccttccgccc tcgctctccc tccgcgccac    120

cggaccccgt agccccgcgc gcccccagac ctttaagcca gatgatgaac ttcctgcggc    180

gccggctgtc ggacagcagc ttcatcgcca atctgcccaa cggctacatg accgacctgc    240

agcggcccga gccccagcaa gcgccgacgc cgccgccccc cggcccgggc gccgcctcgg    300

cctaggcggc gcccccgacc gcctcgccgg gaccggagcg gacgccgccg gccgcctagg    360

cgcccgcgcc gtaagacgcg ccgaagaccg cgcccccccc cccgcgcgaa caccgtcggt    420

gggcagcagc ttattcagct cgctgtccca agcggtaaag cagacggccg cctcggctgg    480

cctggtggac gcgcccggtg ccgcgccggc agccgccagg aaggccaagg tgctgctggt    540

ggtcgacgag ccgcacgccg actgggccaa gtgctttcgg ggcaaaaaag tccttggaga    600

ttatgatatc aaggtggaac aggcagaatt ttcagagctc aacctggtgg cccatgcaga    660

tggcacctat gctgtggata tgcaggttct ccggaatggc acaaaggttg tccggtcctt    720

ccggccagac ttcgtgctca tccggcagca tgcatttggc atggcggaga atgaggactt    780

ccgccacctg atcattggta tgcagtatgc aggcctcccc agcatcaact cactggaatc    840

catatacaac ttctgtgaca agccatgggt gtttgcccag ctggtcgcta tctataagac    900

actgggagga gaaaagttcc ctctcattga acagacatac taccccaacc acaaagagat    960

gctgacactg cccacgttcc ctgtggtggt gaagattggc cacgctcact caggcatggg   1020

caaggtcaaa gtggaaaacc actacgactt ccaggacatt gccagcgtgg tggctctcac   1080

ccagacctat gccactgcag agcctttcat tgactccaag tatgacatcc gggtccagaa   1140

gattggcaac aactacaagg cttacatgag gacatcgatc tcagggaact ggaagacgaa   1200

cactggctct gcgatgctgg agcagattgc catgtcagac aggtacaaac tgtgggtgga   1260

cacctgctct gagatgtttg gcggcctgga catctgtgct gtcaaagctg tacatggcaa   1320

agatgggaaa gactacattt ttgaggtcat ggactgtagc atgccactga ttggggaaca   1380

tcaggtggag gacaggcaac tcatcaccga actagtcatc agcaagatga accagctgct   1440

gtccaggact cctgccctgt ctcctcagag acccctaaca acccagcagc cacagagcgg   1500

aacacttaag gatccggact caagcaagac cccacctcag cggccacccc ctcaaggggg   1560

ccctgggcaa ccccaaggaa tgcagccccc aggcaaggtg ctgcctccac gccggctccc   1620

ccctggacca tcactgccac cttcctcctc ttcctcctct tcttcctcct cctcggctcc   1680

tcagcggccg ggcggcccca ccacccacgg agatgcaccc tccagcagca gctccctggc   1740

agaggcccag ccacccctgg ctgctccacc acagaagccc cagcctcacc cacagctcaa   1800

caagtcgcag tccctgacaa atgccttcag cttctctgag tcctccttct tccggtcttc   1860

agccaatgag gatgaagcca aagcagagac catccggagc ttgaggaagt cctttgccag   1920

cctcttttca gattagctct tcagacacac ggggcaccca gcccaaccgg gaaaggcatc   1980

taagacattc accaacaaca gtcagccagc ttggtggtta tgtcccatga ccttgacgtg   2040

tgtggtccct tcctctgctc tgttgtacta agtgatgttg tgcagcccag aaaggaccat   2100

ttgacagtct cagggcaggt gcctacccag caaggggtac ctggcatcag agaggaaaga   2160

gctgcttccc tgtagtcatg agagcttcct tctgaagtca tcgttcgctg tgagtttagt   2220

ggccttattg tgacagtgcc atcatgtctt attcttccct gtgaaaccag gattaatcgt   2280

ggactcctgg cagcttaacc tagctcagtt gcagtgctaa gcatgccccg cccccattca   2340

gtgatacctg tttgggaagt atatacttcc ccaaaagtac tcttggccct aagttttagg   2400

aactttcccc gacctggatc ccttgtcata cctgtgttac tgtttaaagc acacccaccc   2460

aacttacaag atcttaggct gctgtggtgg tgaagcacct tgagtctgct gatattcggg   2520

agaacaagga tctgcagttt ccccttttct cccctctgaa gagtggttct tatgtgcaat   2580

ctgcagtaac cttgaactcc agagctgcac tatagaggag aatgcatgcc actatgacag   2640

cagtatgcca agctttgtgt tcatctccta ataaacgtta agacctttgg tgtaat       2696


<210>  9132
<211>  418
<212>  PRT
<213>  Homosapiens

<400>  9132

Met Gln Val Leu Arg Asn Gly Thr Lys Val Val Arg Ser Phe Arg Pro 
1               5                   10                  15      


Asp Phe Val Leu Ile Arg Gln His Ala Phe Gly Met Ala Glu Asn Glu 
            20                  25                  30          


Asp Phe Arg His Leu Ile Ile Gly Met Gln Tyr Ala Gly Leu Pro Ser 
        35                  40                  45              


Ile Asn Ser Leu Glu Ser Ile Tyr Asn Phe Cys Asp Lys Pro Trp Val 
    50                  55                  60                  


Phe Ala Gln Leu Val Ala Ile Tyr Lys Thr Leu Gly Gly Glu Lys Phe 
65                  70                  75                  80  


Pro Leu Ile Glu Gln Thr Tyr Tyr Pro Asn His Lys Glu Met Leu Thr 
                85                  90                  95      


Leu Pro Thr Phe Pro Val Val Val Lys Ile Gly His Ala His Ser Gly 
            100                 105                 110         


Met Gly Lys Val Lys Val Glu Asn His Tyr Asp Phe Gln Asp Ile Ala 
        115                 120                 125             


Ser Val Val Ala Leu Thr Gln Thr Tyr Ala Thr Ala Glu Pro Phe Ile 
    130                 135                 140                 


Asp Ser Lys Tyr Asp Ile Arg Val Gln Lys Ile Gly Asn Asn Tyr Lys 
145                 150                 155                 160 


Ala Tyr Met Arg Thr Ser Ile Ser Gly Asn Trp Lys Thr Asn Thr Gly 
                165                 170                 175     


Ser Ala Met Leu Glu Gln Ile Ala Met Ser Asp Arg Tyr Lys Leu Trp 
            180                 185                 190         


Val Asp Thr Cys Ser Glu Met Phe Gly Gly Leu Asp Ile Cys Ala Val 
        195                 200                 205             


Lys Ala Val His Gly Lys Asp Gly Lys Asp Tyr Ile Phe Glu Val Met 
    210                 215                 220                 


Asp Cys Ser Met Pro Leu Ile Gly Glu His Gln Val Glu Asp Arg Gln 
225                 230                 235                 240 


Leu Ile Thr Glu Leu Val Ile Ser Lys Met Asn Gln Leu Leu Ser Arg 
                245                 250                 255     


Thr Pro Ala Leu Ser Pro Gln Arg Pro Leu Thr Thr Gln Gln Pro Gln 
            260                 265                 270         


Ser Gly Thr Leu Lys Asp Pro Asp Ser Ser Lys Thr Pro Pro Gln Arg 
        275                 280                 285             


Pro Pro Pro Gln Gly Gly Pro Gly Gln Pro Gln Gly Met Gln Pro Pro 
    290                 295                 300                 


Gly Lys Val Leu Pro Pro Arg Arg Leu Pro Pro Gly Pro Ser Leu Pro 
305                 310                 315                 320 


Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Pro Gln Arg 
                325                 330                 335     


Pro Gly Gly Pro Thr Thr His Gly Asp Ala Pro Ser Ser Ser Ser Ser 
            340                 345                 350         


Leu Ala Glu Ala Gln Pro Pro Leu Ala Ala Pro Pro Gln Lys Pro Gln 
        355                 360                 365             


Pro His Pro Gln Leu Asn Lys Ser Gln Ser Leu Thr Asn Ala Phe Ser 
    370                 375                 380                 


Phe Ser Glu Ser Ser Phe Phe Arg Ser Ser Ala Asn Glu Asp Glu Ala 
385                 390                 395                 400 


Lys Ala Glu Thr Ile Arg Ser Leu Arg Lys Ser Phe Ala Ser Leu Phe 
                405                 410                 415     


Ser Asp 
        


<210>  9133
<211>  2701
<212>  DNA
<213>  Homosapiens

<400>  9133
tgcggggtct ggtgccgggg cctgagtctc tgctggctaa gccgacgcct cagccgcctc     60

agtcgcctca atctcgcctt ccgccctcgc tctccctccg cgccaccgga ccccgtagcc    120

ccgcgcgccc ccagaccttt aagccagatg atgaacttcc tgcggcgccg gctgtcggac    180

agcagcttca tcgccaatct gcccaacggc tacatgaccg acctgcagcg gcccgagccc    240

cagcaagcgc cgacgccgcc gccccccggc ccgggcgccg cctcggccta ggcggcgccc    300

ccgaccgcct cgccgggacc ggagcggacg ccgccggccg cctaggcgcc cgcgccgtaa    360

gacgcgccga agaccgcgcc cccccccccg cgcgaacacc gtcggtgggc agcagcttat    420

tcagctcgct gtcccaagcg gtaaagcaga cggccgcctc ggctggcctg gtggacgcgc    480

ccggtgccgc gccggcagcc gccaggaagg ccaaggtgct gctggtggtc gacgagccgc    540

acgccgactg ggccaagtgc tttcggggca aaaaagtcct tggagattat gatatcaagg    600

tggaacaggc agaattttca gagctcaacc tggtggccca tgcagatggc acctatgctg    660

tggatatgca ggttctccgg aatggcacaa aggttgtccg gtccttccgg ccagacttcg    720

tgctcatccg gcagcatgca tttggcatgg cggagaatga ggacttccgc cacctgatca    780

ttggtatgca gtatgcaggc ctccccagca tcaactcact ggaatccata tacaacttct    840

gtgacaagcc atgggtgttt gcccagctgg tcgctatcta taagacactg ggaggagaaa    900

agttccctct cattgaacag acatactacc ccaaccacaa agagatgctg acactgccca    960

cgttccctgt ggtggtgaag attggccacg ctcactcagg catgggcaag gtcaaagtgg   1020

aaaaccacta cgacttccag gacattgcca gcgtggtggc tctcacccag acctatgcca   1080

ctgcagagcc tttcattgac tccaagtatg acatccgggt ccagaagatt ggcaacaact   1140

acaaggctta catgaggaca tcgatctcag ggaactggaa gacgaacact ggctctgcga   1200

tgctggagca gattgccatg tcagacaggt acaaactgtg ggtggacacc tgctctgaga   1260

tgtttggcgg cctggacatc tgtgctgtca aagctgtaca tggcaaagat gggaaagact   1320

acatttttga ggtcatggac tgtagcatgc cactgattgg ggaacatcag gtggaggaca   1380

ggcaactcat caccgaacta gtcatcagca agatgaacca gctgctgtcc aggactcctg   1440

ccctgtctcc tcagagaccc ctaacaaccc agcagccaca gagcggaaca cttaaggatc   1500

cggactcaag caagacccca cctcagcggc caccccctca agggggccct gggcaacccc   1560

aaggaatgca gcccccaggc aaggtgctgc ctccacgccg gctcccccct ggaccatcac   1620

tgccaccttc ctcctcttcc tcctcttctt cctcctcctc ggctcctcag cggccgggcg   1680

gccccaccac ccacggagat gcaccctcca gcagcagctc cctggcagag gcccagccac   1740

ccctggctgc tccaccacag aagccccagc ctcacccaca gctcaacaag tcgcagtccc   1800

tgacaaatgc cttcagcttc tctgagtcct ccttcttccg gtcttcagcc aatgaggatg   1860

aagccaaagc agagaccatc cggagcttga ggaagtcctt tgccagcctc ttttcagatt   1920

agctcttcag acacacgggg cacccagccc aaccgggaaa ggcatctaag acattcacca   1980

acaacagtca gccagcttgg tggttatgtc ccatgacctt gacgtgtgtg gtcccttcct   2040

ctgctctgtt gtactaagtg atgttgtgca gcccagaaag gaccatttga cagtctcagg   2100

gcaggtgcct acccagcaag gggtacctgg catcagagag gaaagagctg cttccctgta   2160

gtcatgagag cttccttctg aagtcatcgt tcgctgtgag tttagtggcc ttattgtgac   2220

agtgccatca tgtcttattc ttccctgtga aaccaggatt aatcgtggac tcctggcagc   2280

ttaacctagc tcagttgcag tgctaagcat gccccgcccc cattcagtga tacctgtttg   2340

ggaagtatat acttccccaa aagtactctt ggccctaagt tttaggaact ttccccgacc   2400

tggatccctt gtcatacctg tgttactgtt taaagcacac ccacccaact tacaagatct   2460

taggctgctg tggtggtgaa gcaccttgag tctgctgata ttcgggagaa caaggatctg   2520

cagtttcccc ttttctcccc tctgaagagt ggttcttatg tgcaatctgc agtaaccttg   2580

aactccagag ctgcactata gaggagaatg catgccacta tgacagcagt atgccaagct   2640

ttgtgttcat ctcctaataa acgttaagac ctttggtgta ataaaagcag cagcattcac   2700

c                                                                   2701


<210>  9134
<211>  418
<212>  PRT
<213>  Homosapiens

<400>  9134

Met Gln Val Leu Arg Asn Gly Thr Lys Val Val Arg Ser Phe Arg Pro 
1               5                   10                  15      


Asp Phe Val Leu Ile Arg Gln His Ala Phe Gly Met Ala Glu Asn Glu 
            20                  25                  30          


Asp Phe Arg His Leu Ile Ile Gly Met Gln Tyr Ala Gly Leu Pro Ser 
        35                  40                  45              


Ile Asn Ser Leu Glu Ser Ile Tyr Asn Phe Cys Asp Lys Pro Trp Val 
    50                  55                  60                  


Phe Ala Gln Leu Val Ala Ile Tyr Lys Thr Leu Gly Gly Glu Lys Phe 
65                  70                  75                  80  


Pro Leu Ile Glu Gln Thr Tyr Tyr Pro Asn His Lys Glu Met Leu Thr 
                85                  90                  95      


Leu Pro Thr Phe Pro Val Val Val Lys Ile Gly His Ala His Ser Gly 
            100                 105                 110         


Met Gly Lys Val Lys Val Glu Asn His Tyr Asp Phe Gln Asp Ile Ala 
        115                 120                 125             


Ser Val Val Ala Leu Thr Gln Thr Tyr Ala Thr Ala Glu Pro Phe Ile 
    130                 135                 140                 


Asp Ser Lys Tyr Asp Ile Arg Val Gln Lys Ile Gly Asn Asn Tyr Lys 
145                 150                 155                 160 


Ala Tyr Met Arg Thr Ser Ile Ser Gly Asn Trp Lys Thr Asn Thr Gly 
                165                 170                 175     


Ser Ala Met Leu Glu Gln Ile Ala Met Ser Asp Arg Tyr Lys Leu Trp 
            180                 185                 190         


Val Asp Thr Cys Ser Glu Met Phe Gly Gly Leu Asp Ile Cys Ala Val 
        195                 200                 205             


Lys Ala Val His Gly Lys Asp Gly Lys Asp Tyr Ile Phe Glu Val Met 
    210                 215                 220                 


Asp Cys Ser Met Pro Leu Ile Gly Glu His Gln Val Glu Asp Arg Gln 
225                 230                 235                 240 


Leu Ile Thr Glu Leu Val Ile Ser Lys Met Asn Gln Leu Leu Ser Arg 
                245                 250                 255     


Thr Pro Ala Leu Ser Pro Gln Arg Pro Leu Thr Thr Gln Gln Pro Gln 
            260                 265                 270         


Ser Gly Thr Leu Lys Asp Pro Asp Ser Ser Lys Thr Pro Pro Gln Arg 
        275                 280                 285             


Pro Pro Pro Gln Gly Gly Pro Gly Gln Pro Gln Gly Met Gln Pro Pro 
    290                 295                 300                 


Gly Lys Val Leu Pro Pro Arg Arg Leu Pro Pro Gly Pro Ser Leu Pro 
305                 310                 315                 320 


Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Pro Gln Arg 
                325                 330                 335     


Pro Gly Gly Pro Thr Thr His Gly Asp Ala Pro Ser Ser Ser Ser Ser 
            340                 345                 350         


Leu Ala Glu Ala Gln Pro Pro Leu Ala Ala Pro Pro Gln Lys Pro Gln 
        355                 360                 365             


Pro His Pro Gln Leu Asn Lys Ser Gln Ser Leu Thr Asn Ala Phe Ser 
    370                 375                 380                 


Phe Ser Glu Ser Ser Phe Phe Arg Ser Ser Ala Asn Glu Asp Glu Ala 
385                 390                 395                 400 


Lys Ala Glu Thr Ile Arg Ser Leu Arg Lys Ser Phe Ala Ser Leu Phe 
                405                 410                 415     


Ser Asp 
        


<210>  9135
<211>  1101
<212>  DNA
<213>  Homosapiens

<400>  9135
ctgagtctct gctggctaag ccgacgcctc agccgcctca gtcgcctcaa tctcgccttc     60

cgccttcttc ctcctcctcg gctcctcagc ggccgggcgg ccccaccacc cacggagatg    120

caccctccag cagcagctcc ctggcagagg cccagccacc cctggctgct ccaccacaga    180

agccccagcc tcacccacag ctcaacaagt cgcagtccct gacaaatgcc ttcagcttct    240

ctgagtcctc cttcttccgg tcttcagcca atgaggatga agccaaagca gagaccatcc    300

ggagcttgag gaagtccttt gccagcctct tttcagatta gctcttcaga cacacggggc    360

acccagccca accgggaaag gcatctaaga cattcaccaa caacagtcag ccagcttggt    420

ggttatgtcc catgaccttg acgtgtgtgg tcccttcctc tgctctgttg tactaagtga    480

tgttgtgcag cccagaaagg accatttgac agtctcaggg caggtgccta cccagcaagg    540

ggtacctggc atcagagagg aaagagctgc ttccctgtag tcatgagagc ttccttctga    600

agtcatcgtt cgctgtgagt ttagtggcct tattgtgaca gtgccatcat gtcttattct    660

tccctgtgaa accaggatta atcgtggact cctggcagct taacctagct cagttgcagt    720

gctaagcatg ccccgccccc attcagtgat acctgtttgg gaagtatata cttccccaaa    780

agtactcttg gccctaagtt ttaggaactt tccccgacct ggatcccttg tcatacctgt    840

gttactgttt aaagcacacc cacccaactt acaagatctt aggctgctgt ggtggtgaag    900

caccttgagt ctgctgatat tcgggagaac aaggatctgc agtttcccct tttctcccct    960

ctgaagagtg gttcttatgt gcaatctgca gtaaccttga actccagagc tgcactatag   1020

aggagaatgc atgccactat gacagcagta tgccaagctt tgtgttcatc tcctaataaa   1080

cgttaagacc tttggtgtaa t                                             1101


<210>  9136
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  9136

Met His Pro Pro Ala Ala Ala Pro Trp Gln Arg Pro Ser His Pro Trp 
1               5                   10                  15      


Leu Leu His His Arg Ser Pro Ser Leu Thr His Ser Ser Thr Ser Arg 
            20                  25                  30          


Ser Pro 
        


<210>  9137
<211>  1120
<212>  DNA
<213>  Homosapiens

<400>  9137
ctgagtctct gctggctaag ccgacgcctc agccgcctca gtcgcctcaa tctcgccttc     60

cgccttcttc ctcctcctcg gctcctcagc ggccgggcgg ccccaccacc cacggagatg    120

caccctccag cagcagctcc ctggcagagg cccagccacc cctggctgct ccaccacaga    180

agccccagcc tcacccacag ctcaacaagt cgcagtccct gacaaatgcc ttcagcttct    240

ctgagtcctc cttcttccgg tcttcagcca atgaggatga agccaaagca gagaccatcc    300

ggagcttgag gaagtccttt gccagcctct tttcagatta gctcttcaga cacacggggc    360

acccagccca accgggaaag gcatctaaga cattcaccaa caacagtcag ccagcttggt    420

ggttatgtcc catgaccttg acgtgtgtgg tcccttcctc tgctctgttg tactaagtga    480

tgttgtgcag cccagaaagg accatttgac agtctcaggg caggtgccta cccagcaagg    540

ggtacctggc atcagagagg aaagagctgc ttccctgtag tcatgagagc ttccttctga    600

agtcatcgtt cgctgtgagt ttagtggcct tattgtgaca gtgccatcat gtcttattct    660

tccctgtgaa accaggatta atcgtggact cctggcagct taacctagct cagttgcagt    720

gctaagcatg ccccgccccc attcagtgat acctgtttgg gaagtatata cttccccaaa    780

agtactcttg gccctaagtt ttaggaactt tccccgacct ggatcccttg tcatacctgt    840

gttactgttt aaagcacacc cacccaactt acaagatctt aggctgctgt ggtggtgaag    900

caccttgagt ctgctgatat tcgggagaac aaggatctgc agtttcccct tttctcccct    960

ctgaagagtg gttcttatgt gcaatctgca gtaaccttga actccagagc tgcactatag   1020

aggagaatgc atgccactat gacagcagta tgccaagctt tgtgttcatc tcctaataaa   1080

cgttaagacc tttggtgtaa taaaagcagc agcattcacc                         1120


<210>  9138
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  9138

Met His Pro Pro Ala Ala Ala Pro Trp Gln Arg Pro Ser His Pro Trp 
1               5                   10                  15      


Leu Leu His His Arg Ser Pro Ser Leu Thr His Ser Ser Thr Ser Arg 
            20                  25                  30          


Ser Pro 
        


<210>  9139
<211>  2069
<212>  DNA
<213>  Homosapiens

<400>  9139
aggagattgc tgcctatgca aagcaggtaa gaagccgaac tctgaggcct ctcgccattg     60

tctccgagtc ggccagctgg agcgttttcg gggctgtaaa gggagaatgg cgcatgcgca    120

tattcagggc ggaaggcgcg ctaagagcag atttgtggtc tgcattatgt ctggagccag    180

aagtaagctt gctcttttcc tctgcggctg ttacgtggtt gccctgggag cccacaccgg    240

ggaggagagc gtggctgacc atcacgaggc tgaatattat gtggctgccg tgtatgagca    300

tccatccatc ctgagtctga accctctggc tctcatcagc cgccaagagg ccttggagct    360

catgaaccag aaccttgaca tctatgaaca gcaagtgatg actgcagccc aaaaggatgt    420

acagattata gtgtttccag aagatggcat tcatggattc aactttacaa gaacatccat    480

ttatccattt ttggacttca tgccgtctcc ccaggtggtc aggtggaacc catgcctgga    540

gcctcaccgc ttcaatgaca cagaggtgct ccagcgcctg agttgtatgg ccatcagggg    600

agatatgttc ttggtggcca atcttgggac aaaggagcct tgtcatagca gtgacccaag    660

gtgcccaaaa gatgggagat accagttcaa cacaaatgtc gtgttcagca ataatggaac    720

ccttgttgac cgctaccgta aacacaacct ctactttgag gcagcattcg atgttcctct    780

taaagtggat ctcatcacct ttgatacccc ctttgctggc aggtttggca tcttcacatg    840

ctttgatata ttgttctttg accctgccat cagagtcctc agagactaca aggtgaagca    900

tgttgtgtac ccaactgcct ggatgaacca gctcccactc ttggcagcaa ttgagattca    960

gaaagctttt gctgttgcct ttggcatcaa cgttctggca gctaatgtcc accacccagt   1020

tctggggatg acaggaagtg gcatacacac ccctctggag tccttttggt accatgacat   1080

ggaaaatccc aaaagtcacc ttataattgc ccaggtggcc aaaaatccag tgggtctcat   1140

tggtgcagag aatgcaacag gtgaaacgga cccatcccat agtaagtttt taaaaatttt   1200

gtcaggcgat ccgtactgtg agaaggatgc tcaggaagtc cactgtgatg aggccaccaa   1260

gtggaacgtg aatgctcctc ccacatttca ctctgagatg atgtatgaca atttcaccct   1320

ggtccctgtc tggggaaagg aaggctatct ccacgtctgt tccaatggcc tctgctgtta   1380

tttactttac gagaggccca ccttatccaa agagctgtat gccctggggg tctttgatgg   1440

gcttcacaca gtacatggca cttactacat ccaagtgtgt gccctggtca ggtgtggggg   1500

tcttggcttc gacacctgtg gacaggaaat cacagaggcc acggggatat ttgagtttca   1560

cctgtggggc aacttcagta cttcctatat ctttcctttg tttctgacct cagggatgac   1620

cctagaagtc cctgaccagc ttggctggga gaatgaccac tatttcctga ggaaaagtag   1680

gctgtcctct gggctggtga cggcggctct ctatgggcgc ttgtatgaga gggactagga   1740

aaagtgtgtg gtctgtgggg cggactctgg ccatcatgtt gacagccttg cacttccaca   1800

ggctacaagc cctgggacca tctttctgcc ttaagggcag gagcccactt ctgtggcacc   1860

agattccacc ctgggaactg tggaaaaagt aggagaggca gattccctca gtgtcttcct   1920

cttaaacctc aatcatcgag acattagggg gtattttctg ttcacattta tctttttcaa   1980

gccacatctt cctctaacaa atctctcagt atgcgattgg tctcaagcta aaacaaaaat   2040

aaatgtcagt ttatatttta cacatccac                                     2069


<210>  9140
<211>  543
<212>  PRT
<213>  Homosapiens

<400>  9140

Met Ala His Ala His Ile Gln Gly Gly Arg Arg Ala Lys Ser Arg Phe 
1               5                   10                  15      


Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu 
            20                  25                  30          


Cys Gly Cys Tyr Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser 
        35                  40                  45              


Val Ala Asp His His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu 
    50                  55                  60                  


His Pro Ser Ile Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln 
65                  70                  75                  80  


Glu Ala Leu Glu Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln 
                85                  90                  95      


Val Met Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu 
            100                 105                 110         


Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe 
        115                 120                 125             


Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu 
    130                 135                 140                 


Glu Pro His Arg Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys 
145                 150                 155                 160 


Met Ala Ile Arg Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys 
                165                 170                 175     


Glu Pro Cys His Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr 
            180                 185                 190         


Gln Phe Asn Thr Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp 
        195                 200                 205             


Arg Tyr Arg Lys His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro 
    210                 215                 220                 


Leu Lys Val Asp Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe 
225                 230                 235                 240 


Gly Ile Phe Thr Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg 
                245                 250                 255     


Val Leu Arg Asp Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp 
            260                 265                 270         


Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe 
        275                 280                 285             


Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro 
    290                 295                 300                 


Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe 
305                 310                 315                 320 


Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln 
                325                 330                 335     


Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly 
            340                 345                 350         


Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp 
        355                 360                 365             


Pro Tyr Cys Glu Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr 
    370                 375                 380                 


Lys Trp Asn Val Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr 
385                 390                 395                 400 


Asp Asn Phe Thr Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His 
                405                 410                 415     


Val Cys Ser Asn Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr 
            420                 425                 430         


Leu Ser Lys Glu Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr 
        435                 440                 445             


Val His Gly Thr Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly 
    450                 455                 460                 


Gly Leu Gly Phe Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly 
465                 470                 475                 480 


Ile Phe Glu Phe His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe 
                485                 490                 495     


Pro Leu Phe Leu Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu 
            500                 505                 510         


Gly Trp Glu Asn Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser 
        515                 520                 525             


Gly Leu Val Thr Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 
    530                 535                 540             


<210>  9141
<211>  2280
<212>  DNA
<213>  Homosapiens

<400>  9141
aggagattgc tgcctatgca aagcaggtaa gaagccgaac tctgaggcct ctcgccattg     60

tctccgagtc ggccagctgg agcgttttcg gggctgtaaa gggagaatgg cgcatgcgca    120

tattcagggc ggaaggcgcg ctaagagcag atttgtggtc tgcattatgt ctggagccag    180

aagtaagctt gctcttttcc tctgcggctg ttacgtggtt gccctgggag cccacaccgg    240

ggaggagagc gtggctgacc atcacgaggc tgaatattat gtggctgccg tgtatgagca    300

tccatccatc ctgagtctga accctctggc tctcatcagc cgccaagagg ccttggagct    360

catgaaccag aaccttgaca tctatgaaca gcaagtgatg actgcagccc aaaaggatgt    420

acagattata gtgtttccag aagatggcat tcatggattc aactttacaa gaacatccat    480

ttatccattt ttggacttca tgccgtctcc ccaggtggtc aggtggaacc catgcctgga    540

gcctcaccgc ttcaatgaca cagaggtgct ccagcgcctg agttgtatgg ccatcagggg    600

agatatgttc ttggtggcca atcttgggac aaaggagcct tgtcatagca gtgacccaag    660

gtgcccaaaa gatgggagat accagttcaa cacaaatgtc gtgttcagca ataatggaac    720

ccttgttgac cgctaccgta aacacaacct ctactttgag gcagcattcg atgttcctct    780

taaagtggat ctcatcacct ttgatacccc ctttgctggc aggtttggca tcttcacatg    840

ctttgatata ttgttctttg accctgccat cagagtcctc agagactaca aggtgaagca    900

tgttgtgtac ccaactgcct ggatgaacca gctcccactc ttggcagcaa ttgagattca    960

gaaagctttt gctgttgcct ttggcatcaa cgttctggca gctaatgtcc accacccagt   1020

tctggggatg acaggaagtg gcatacacac ccctctggag tccttttggt accatgacat   1080

ggaaaatccc aaaagtcacc ttataattgc ccaggtggcc aaaaatccag tgggtctcat   1140

tggtgcagag aatgcaacag gtgaaacgga cccatcccat agtaagtttt taaaaatttt   1200

gtcaggcgat ccgtactgtg agaaggatgc tcaggaagtc cactgtgatg aggccaccaa   1260

gtggaacgtg aatgctcctc ccacatttca ctctgagatg atgtatgaca atttcaccct   1320

ggtccctgtc tggggaaagg aaggctatct ccacgtctgt tccaatggcc tctgctgtta   1380

tttactttac gagaggccca ccttatccaa agagctgtat gccctggggg tctttgatgg   1440

gcttcacaca gtacatggca cttactacat ccaagtgtgt gccctggtca ggtgtggggg   1500

tcttggcttc gacacctgtg gacaggaaat cacagaggcc acggggatat ttgagtttca   1560

cctgtggggc aacttcagta cttcctatat ctttcctttg tttctgacct cagggatgac   1620

cctagaagtc cctgaccagc ttggctggga gaatgaccac tatttcctga ggaaaagtag   1680

gctgtcctct gggctggtga cggcggctct ctatgggcgc ttgtatgaga gggactagga   1740

aaagtgtgtg gtctgtgggg cggactctgg ccatcatgtt gacagccttg cacttccaca   1800

ggctacaagc cctgggacca tctttctgcc ttaagggcag gagcccactt ctgtggcacc   1860

agattccacc ctgggaactg tggaaaaagt aggagaggca gattccctca gtgtcttcct   1920

cttaaacctc aatcatcgag acattagggg gtattttctg ttcacattta tctttttcaa   1980

gccacatctt cctctaacaa atctctcagt atgcgattgg tctcaagcta aaacaaaaat   2040

aaatgtcagt ttatatttta cacatccaca aagcagtggc ttggggtttt tttttttttt   2100

tttatcttgt tgatcaagtg acacccagga catgtaaata tttcataagc cttaaacatt   2160

tcctgaggta agaaacaagc tctcaaagca aaagctcaat tagaaatggc ccttgtgggg   2220

aaccttccca ttctggtcga ccagaactct agccagatga aatggcaatg ctagcgccac   2280


<210>  9142
<211>  543
<212>  PRT
<213>  Homosapiens

<400>  9142

Met Ala His Ala His Ile Gln Gly Gly Arg Arg Ala Lys Ser Arg Phe 
1               5                   10                  15      


Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu 
            20                  25                  30          


Cys Gly Cys Tyr Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser 
        35                  40                  45              


Val Ala Asp His His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu 
    50                  55                  60                  


His Pro Ser Ile Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln 
65                  70                  75                  80  


Glu Ala Leu Glu Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln 
                85                  90                  95      


Val Met Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu 
            100                 105                 110         


Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe 
        115                 120                 125             


Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu 
    130                 135                 140                 


Glu Pro His Arg Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys 
145                 150                 155                 160 


Met Ala Ile Arg Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys 
                165                 170                 175     


Glu Pro Cys His Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr 
            180                 185                 190         


Gln Phe Asn Thr Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp 
        195                 200                 205             


Arg Tyr Arg Lys His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro 
    210                 215                 220                 


Leu Lys Val Asp Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe 
225                 230                 235                 240 


Gly Ile Phe Thr Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg 
                245                 250                 255     


Val Leu Arg Asp Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp 
            260                 265                 270         


Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe 
        275                 280                 285             


Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro 
    290                 295                 300                 


Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe 
305                 310                 315                 320 


Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln 
                325                 330                 335     


Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly 
            340                 345                 350         


Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp 
        355                 360                 365             


Pro Tyr Cys Glu Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr 
    370                 375                 380                 


Lys Trp Asn Val Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr 
385                 390                 395                 400 


Asp Asn Phe Thr Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His 
                405                 410                 415     


Val Cys Ser Asn Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr 
            420                 425                 430         


Leu Ser Lys Glu Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr 
        435                 440                 445             


Val His Gly Thr Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly 
    450                 455                 460                 


Gly Leu Gly Phe Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly 
465                 470                 475                 480 


Ile Phe Glu Phe His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe 
                485                 490                 495     


Pro Leu Phe Leu Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu 
            500                 505                 510         


Gly Trp Glu Asn Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser 
        515                 520                 525             


Gly Leu Val Thr Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 
    530                 535                 540             


<210>  9143
<211>  756
<212>  DNA
<213>  Homosapiens

<400>  9143
agattgctgc ctatgcaaag caggtaagaa gccgaactct gaggcctctc gccattgtct     60

ccgagtcggc cagctggagc gttttcgggg ctgtaaaggg agaatggcgc atgcgcatat    120

tcagggcgga aggcgcgcta agagcagatt tgtggtctgc attatgtctg gagccagaag    180

taagcttgct cttttcctct gcggctgtta cgtggttgcc ctgggagccc acaccgggga    240

ggagagcgtg gctgaccatc acgaggctga atattatgtg gctgccgtgt atgagcatcc    300

atccatcctg agtctgaacc ctctggctct catcagccgc caagaggcct tggagctcat    360

gaaccagaac cttgacatct atgaacagca agtgatgact gcagcccaaa aggatgtaca    420

gattatagtg tttccagaag atggcattca tggattcaac tttacaagaa catccattta    480

tccatttttg gacttcatgc cgtctcccca ggtggtcagg tggaacccat gcctggagcc    540

tcaccgcttc aatgacacag aggtgattcc tgcctttttc ctcagtaggc tgagggtaca    600

cagaggtgat ctaagtcagg gaccagaagc tgtgacatgt taactaagat tgataggaga    660

ccttaacatc cccaaaatcc aacccaaact cccaaagatc catgtgccac atgttcattc    720

cattaaagaa tgtctgacgt tacaaggcag ttattc                              756


<210>  9144
<211>  179
<212>  PRT
<213>  Homosapiens

<400>  9144

Met Ala His Ala His Ile Gln Gly Gly Arg Arg Ala Lys Ser Arg Phe 
1               5                   10                  15      


Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu 
            20                  25                  30          


Cys Gly Cys Tyr Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser 
        35                  40                  45              


Val Ala Asp His His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu 
    50                  55                  60                  


His Pro Ser Ile Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln 
65                  70                  75                  80  


Glu Ala Leu Glu Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln 
                85                  90                  95      


Val Met Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu 
            100                 105                 110         


Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe 
        115                 120                 125             


Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu 
    130                 135                 140                 


Glu Pro His Arg Phe Asn Asp Thr Glu Val Ile Pro Ala Phe Phe Leu 
145                 150                 155                 160 


Ser Arg Leu Arg Val His Arg Gly Asp Leu Ser Gln Gly Pro Glu Ala 
                165                 170                 175     


Val Thr Cys 
            


<210>  9145
<211>  1306
<212>  DNA
<213>  Homosapiens

<400>  9145
agattgctgc ctatgcaaag caggtaagaa gccgaactct gaggcctctc gccattgtct     60

ccgagtcggc cagctggagc gttttcgggg ctgtaaaggg agaatggcgc atgcgcatat    120

tcagggcgga aggcgcgcta agagcagatt tgtggtctgc attatgtctg gagccagaag    180

taagcttgct cttttcctct gcggctgtta cgtggttgcc ctgggagccc acaccgggga    240

ggagagcgtg gctgaccatc acgaggctga atattatgtg gctgccgtgt atgagcatcc    300

atccatcctg agtctgaacc ctctggctct catcagccgc caagaggcct tggagctcat    360

gaaccagaac cttgacatct atgaacagca agtgatgact gcagcccaaa aggatgtaca    420

gattatagtg tttccagaag atggcattca tggattcaac tttacaagaa catccattta    480

tccatttttg gacttcatgc cgtctcccca ggtggtcagg tggaacccat gcctggagcc    540

tcaccgcttc aatgacacag aggtgattcc tgcctttttc ctcagtaggc tgagggtaca    600

cagaggtgat ctaagtcagg gaccagaagc tgtgacatgt taactaagat tgataggaga    660

ccttaacatc cccaaaatcc aacccaaact cccaaagatc catgtgccac atgttcattc    720

cattaaagaa tgtctgacgt tacaaggcag ttattcatct atggatcttt ccatttatta    780

attacacaat aaatacagga atgtatactt aaaccaaacc aaaagtaaaa aaagaaaagt    840

tcatcttcac cacagcctgc acctcatccc atgcccttgc ttagagaaac tgccatcaac    900

aatttgatgt gcattcagtt gtattctttt ctatgcattt catagttatt gacatcctct    960

tttttttttt tttttttgag atggagtctt actctgccac ccaggctgga gcgcagtggc   1020

gcgatctcag ctcactgcaa gctctgcctt ccgggttcat gccattctcc tgcctcagcc   1080

tcccgagtag ctgggactac aggcacccac caccacgccc ggctaatttt ttttgtgtgt   1140

gtatttttag tagagatggg gtttcaccat gttagccagg atggtctcga tctcctgacc   1200

ttgtgatctg tctacctcgg cctgccaaag tgctgggatt acaggcatga gccactgtgc   1260

ctggccttga catcctcttt ttaagcatac tatatgctta ttcatt                  1306


<210>  9146
<211>  179
<212>  PRT
<213>  Homosapiens

<400>  9146

Met Ala His Ala His Ile Gln Gly Gly Arg Arg Ala Lys Ser Arg Phe 
1               5                   10                  15      


Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu 
            20                  25                  30          


Cys Gly Cys Tyr Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser 
        35                  40                  45              


Val Ala Asp His His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu 
    50                  55                  60                  


His Pro Ser Ile Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln 
65                  70                  75                  80  


Glu Ala Leu Glu Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln 
                85                  90                  95      


Val Met Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu 
            100                 105                 110         


Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe 
        115                 120                 125             


Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu 
    130                 135                 140                 


Glu Pro His Arg Phe Asn Asp Thr Glu Val Ile Pro Ala Phe Phe Leu 
145                 150                 155                 160 


Ser Arg Leu Arg Val His Arg Gly Asp Leu Ser Gln Gly Pro Glu Ala 
                165                 170                 175     


Val Thr Cys 
            


<210>  9147
<211>  2227
<212>  DNA
<213>  Homosapiens

<400>  9147
gggagctggg aagcccggcg cgcgtcgttt gctggggctg tttgtgcgtt gctgctgtgc     60

taccgcgttg cgttttctag gcatttactt acacgctttg tggtttacgc tctcataacc    120

ttgtggtttt atagtcctta aattattgta gcgcacgtta cttaaatcca gaagcagatg    180

tgtaccccag caagagataa aatgacgctc agagtcagta gatccagacc gtgcctgaga    240

tcctgaatcc tgtttcctac ccactattca gccattgggt cacaagcgat gaaaagagca    300

ccttgaagat ttgtggtctg cattatgtct ggagccagaa gtaagcttgc tcttttcctc    360

tgcggctgtt acgtggttgc cctgggagcc cacaccgggg aggagagcgt ggctgaccat    420

cacgaggctg aatattatgt ggctgccgtg tatgagcatc catccatcct gagtctgaac    480

cctctggctc tcatcagccg ccaagaggcc ttggagctca tgaaccagaa ccttgacatc    540

tatgaacagc aagtgatgac tgcagcccaa aaggatgtac agattatagt gtttccagaa    600

gatggcattc atggattcaa ctttacaaga acatccattt atccattttt ggacttcatg    660

ccgtctcccc aggtggtcag gtggaaccca tgcctggagc ctcaccgctt caatgacaca    720

gaggtgctcc agcgcctgag ttgtatggcc atcaggggag atatgttctt ggtggccaat    780

cttgggacaa aggagccttg tcatagcagt gacccaaggt gcccaaaaga tgggagatac    840

cagttcaaca caaatgtcgt gttcagcaat aatggaaccc ttgttgaccg ctaccgtaaa    900

cacaacctct actttgaggc agcattcgat gttcctctta aagtggatct catcaccttt    960

gataccccct ttgctggcag gtttggcatc ttcacatgct ttgatatatt gttctttgac   1020

cctgccatca gagtcctcag agactacaag gtgaagcatg ttgtgtaccc aactgcctgg   1080

atgaaccagc tcccactctt ggcagcaatt gagattcaga aagcttttgc tgttgccttt   1140

ggcatcaacg ttctggcagc taatgtccac cacccagttc tggggatgac aggaagtggc   1200

atacacaccc ctctggagtc cttttggtac catgacatgg aaaatcccaa aagtcacctt   1260

ataattgccc aggtggccaa aaatccagtg ggtctcattg gtgcagagaa tgcaacaggt   1320

gaaacggacc catcccatag taagttttta aaaattttgt caggcgatcc gtactgtgag   1380

aaggatgctc aggaagtcca ctgtgatgag gccaccaagt ggaacgtgaa tgctcctccc   1440

acatttcact ctgagatgat gtatgacaat ttcaccctgg tccctgtctg gggaaaggaa   1500

ggctatctcc acgtctgttc caatggcctc tgctgttatt tactttacga gaggcccacc   1560

ttatccaaag agctgtatgc cctgggggtc tttgatgggc ttcacacagt acatggcact   1620

tactacatcc aagtgtgtgc cctggtcagg tgtgggggtc ttggcttcga cacctgtgga   1680

caggaaatca cagaggccac ggggatattt gagtttcacc tgtggggcaa cttcagtact   1740

tcctatatct ttcctttgtt tctgacctca gggatgaccc tagaagtccc tgaccagctt   1800

ggctgggaga atgaccacta tttcctgagg aaaagtaggc tgtcctctgg gctggtgacg   1860

gcggctctct atgggcgctt gtatgagagg gactaggaaa agtgtgtggt ctgtggggcg   1920

gactctggcc atcatgttga cagccttgca cttccacagg ctacaagccc tgggaccatc   1980

tttctgcctt aagggcagga gcccacttct gtggcaccag attccaccct gggaactgtg   2040

gaaaaagtag gagaggcaga ttccctcagt gtcttcctct taaacctcaa tcatcgagac   2100

attagggggt attttctgtt cacatttatc tttttcaagc cacatcttcc tctaacaaat   2160

ctctcagtat gcgattggtc tcaagctaaa acaaaaataa atgtcagttt atattttaca   2220

catccac                                                             2227


<210>  9148
<211>  523
<212>  PRT
<213>  Homosapiens

<400>  9148

Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu Cys Gly Cys Tyr 
1               5                   10                  15      


Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser Val Ala Asp His 
            20                  25                  30          


His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu His Pro Ser Ile 
        35                  40                  45              


Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln Glu Ala Leu Glu 
    50                  55                  60                  


Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln Val Met Thr Ala 
65                  70                  75                  80  


Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu Asp Gly Ile His 
                85                  90                  95      


Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe Leu Asp Phe Met 
            100                 105                 110         


Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu Glu Pro His Arg 
        115                 120                 125             


Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys Met Ala Ile Arg 
    130                 135                 140                 


Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys Glu Pro Cys His 
145                 150                 155                 160 


Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr Gln Phe Asn Thr 
                165                 170                 175     


Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp Arg Tyr Arg Lys 
            180                 185                 190         


His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro Leu Lys Val Asp 
        195                 200                 205             


Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe Gly Ile Phe Thr 
    210                 215                 220                 


Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg Val Leu Arg Asp 
225                 230                 235                 240 


Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp Met Asn Gln Leu 
                245                 250                 255     


Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe Ala Val Ala Phe 
            260                 265                 270         


Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro Val Leu Gly Met 
        275                 280                 285             


Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe Trp Tyr His Asp 
    290                 295                 300                 


Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln Val Ala Lys Asn 
305                 310                 315                 320 


Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly Glu Thr Asp Pro 
                325                 330                 335     


Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp Pro Tyr Cys Glu 
            340                 345                 350         


Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr Lys Trp Asn Val 
        355                 360                 365             


Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr Asp Asn Phe Thr 
    370                 375                 380                 


Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His Val Cys Ser Asn 
385                 390                 395                 400 


Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr Leu Ser Lys Glu 
                405                 410                 415     


Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr Val His Gly Thr 
            420                 425                 430         


Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly Gly Leu Gly Phe 
        435                 440                 445             


Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly Ile Phe Glu Phe 
    450                 455                 460                 


His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe Pro Leu Phe Leu 
465                 470                 475                 480 


Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu Gly Trp Glu Asn 
                485                 490                 495     


Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser Gly Leu Val Thr 
            500                 505                 510         


Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 
        515                 520             


<210>  9149
<211>  2438
<212>  DNA
<213>  Homosapiens

<400>  9149
gggagctggg aagcccggcg cgcgtcgttt gctggggctg tttgtgcgtt gctgctgtgc     60

taccgcgttg cgttttctag gcatttactt acacgctttg tggtttacgc tctcataacc    120

ttgtggtttt atagtcctta aattattgta gcgcacgtta cttaaatcca gaagcagatg    180

tgtaccccag caagagataa aatgacgctc agagtcagta gatccagacc gtgcctgaga    240

tcctgaatcc tgtttcctac ccactattca gccattgggt cacaagcgat gaaaagagca    300

ccttgaagat ttgtggtctg cattatgtct ggagccagaa gtaagcttgc tcttttcctc    360

tgcggctgtt acgtggttgc cctgggagcc cacaccgggg aggagagcgt ggctgaccat    420

cacgaggctg aatattatgt ggctgccgtg tatgagcatc catccatcct gagtctgaac    480

cctctggctc tcatcagccg ccaagaggcc ttggagctca tgaaccagaa ccttgacatc    540

tatgaacagc aagtgatgac tgcagcccaa aaggatgtac agattatagt gtttccagaa    600

gatggcattc atggattcaa ctttacaaga acatccattt atccattttt ggacttcatg    660

ccgtctcccc aggtggtcag gtggaaccca tgcctggagc ctcaccgctt caatgacaca    720

gaggtgctcc agcgcctgag ttgtatggcc atcaggggag atatgttctt ggtggccaat    780

cttgggacaa aggagccttg tcatagcagt gacccaaggt gcccaaaaga tgggagatac    840

cagttcaaca caaatgtcgt gttcagcaat aatggaaccc ttgttgaccg ctaccgtaaa    900

cacaacctct actttgaggc agcattcgat gttcctctta aagtggatct catcaccttt    960

gataccccct ttgctggcag gtttggcatc ttcacatgct ttgatatatt gttctttgac   1020

cctgccatca gagtcctcag agactacaag gtgaagcatg ttgtgtaccc aactgcctgg   1080

atgaaccagc tcccactctt ggcagcaatt gagattcaga aagcttttgc tgttgccttt   1140

ggcatcaacg ttctggcagc taatgtccac cacccagttc tggggatgac aggaagtggc   1200

atacacaccc ctctggagtc cttttggtac catgacatgg aaaatcccaa aagtcacctt   1260

ataattgccc aggtggccaa aaatccagtg ggtctcattg gtgcagagaa tgcaacaggt   1320

gaaacggacc catcccatag taagttttta aaaattttgt caggcgatcc gtactgtgag   1380

aaggatgctc aggaagtcca ctgtgatgag gccaccaagt ggaacgtgaa tgctcctccc   1440

acatttcact ctgagatgat gtatgacaat ttcaccctgg tccctgtctg gggaaaggaa   1500

ggctatctcc acgtctgttc caatggcctc tgctgttatt tactttacga gaggcccacc   1560

ttatccaaag agctgtatgc cctgggggtc tttgatgggc ttcacacagt acatggcact   1620

tactacatcc aagtgtgtgc cctggtcagg tgtgggggtc ttggcttcga cacctgtgga   1680

caggaaatca cagaggccac ggggatattt gagtttcacc tgtggggcaa cttcagtact   1740

tcctatatct ttcctttgtt tctgacctca gggatgaccc tagaagtccc tgaccagctt   1800

ggctgggaga atgaccacta tttcctgagg aaaagtaggc tgtcctctgg gctggtgacg   1860

gcggctctct atgggcgctt gtatgagagg gactaggaaa agtgtgtggt ctgtggggcg   1920

gactctggcc atcatgttga cagccttgca cttccacagg ctacaagccc tgggaccatc   1980

tttctgcctt aagggcagga gcccacttct gtggcaccag attccaccct gggaactgtg   2040

gaaaaagtag gagaggcaga ttccctcagt gtcttcctct taaacctcaa tcatcgagac   2100

attagggggt attttctgtt cacatttatc tttttcaagc cacatcttcc tctaacaaat   2160

ctctcagtat gcgattggtc tcaagctaaa acaaaaataa atgtcagttt atattttaca   2220

catccacaaa gcagtggctt ggggtttttt tttttttttt tatcttgttg atcaagtgac   2280

acccaggaca tgtaaatatt tcataagcct taaacatttc ctgaggtaag aaacaagctc   2340

tcaaagcaaa agctcaatta gaaatggccc ttgtggggaa ccttcccatt ctggtcgacc   2400

agaactctag ccagatgaaa tggcaatgct agcgccac                           2438


<210>  9150
<211>  523
<212>  PRT
<213>  Homosapiens

<400>  9150

Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu Cys Gly Cys Tyr 
1               5                   10                  15      


Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser Val Ala Asp His 
            20                  25                  30          


His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu His Pro Ser Ile 
        35                  40                  45              


Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln Glu Ala Leu Glu 
    50                  55                  60                  


Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln Val Met Thr Ala 
65                  70                  75                  80  


Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu Asp Gly Ile His 
                85                  90                  95      


Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe Leu Asp Phe Met 
            100                 105                 110         


Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu Glu Pro His Arg 
        115                 120                 125             


Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys Met Ala Ile Arg 
    130                 135                 140                 


Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys Glu Pro Cys His 
145                 150                 155                 160 


Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr Gln Phe Asn Thr 
                165                 170                 175     


Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp Arg Tyr Arg Lys 
            180                 185                 190         


His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro Leu Lys Val Asp 
        195                 200                 205             


Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe Gly Ile Phe Thr 
    210                 215                 220                 


Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg Val Leu Arg Asp 
225                 230                 235                 240 


Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp Met Asn Gln Leu 
                245                 250                 255     


Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe Ala Val Ala Phe 
            260                 265                 270         


Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro Val Leu Gly Met 
        275                 280                 285             


Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe Trp Tyr His Asp 
    290                 295                 300                 


Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln Val Ala Lys Asn 
305                 310                 315                 320 


Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly Glu Thr Asp Pro 
                325                 330                 335     


Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp Pro Tyr Cys Glu 
            340                 345                 350         


Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr Lys Trp Asn Val 
        355                 360                 365             


Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr Asp Asn Phe Thr 
    370                 375                 380                 


Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His Val Cys Ser Asn 
385                 390                 395                 400 


Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr Leu Ser Lys Glu 
                405                 410                 415     


Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr Val His Gly Thr 
            420                 425                 430         


Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly Gly Leu Gly Phe 
        435                 440                 445             


Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly Ile Phe Glu Phe 
    450                 455                 460                 


His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe Pro Leu Phe Leu 
465                 470                 475                 480 


Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu Gly Trp Glu Asn 
                485                 490                 495     


Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser Gly Leu Val Thr 
            500                 505                 510         


Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 
        515                 520             


<210>  9151
<211>  731
<212>  DNA
<213>  Homosapiens

<400>  9151
cagacagatt tccccacgca gacgctgtgt gtcacagggg gaatgggcag cgtcactttt     60

tacatccagt catattgtat gaaattgcaa caaattcaaa aagatgccat cgtgggagtg    120

tgatttgtgg tctgcattat gtctggagcc agaagtaagc ttgctctttt cctctgcggc    180

tgttacgtgg ttgccctggg agcccacacc ggggaggaga gcgtggctga ccatcacgag    240

gctgaatatt atgtggctgc cgtgtatgag catccatcca tcctgagtct gaaccctctg    300

gctctcatca gccgccaaga ggccttggag ctcatgaacc agaaccttga catctatgaa    360

cagcaagtga tgactgcagc ccaaaaggat gtacagatta tagtgtttcc agaagatggc    420

attcatggat tcaactttac aagaacatcc atttatccat ttttggactt catgccgtct    480

ccccaggtgg tcaggtggaa cccatgcctg gagcctcacc gcttcaatga cacagaggtg    540

attcctgcct ttttcctcag taggctgagg gtacacagag gtgatctaag tcagggacca    600

gaagctgtga catgttaact aagattgata ggagacctta acatccccaa aatccaaccc    660

aaactcccaa agatccatgt gccacatgtt cattccatta aagaatgtct gacgttacaa    720

ggcagttatt c                                                         731


<210>  9152
<211>  159
<212>  PRT
<213>  Homosapiens

<400>  9152

Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu Cys Gly Cys Tyr 
1               5                   10                  15      


Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser Val Ala Asp His 
            20                  25                  30          


His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu His Pro Ser Ile 
        35                  40                  45              


Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln Glu Ala Leu Glu 
    50                  55                  60                  


Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln Val Met Thr Ala 
65                  70                  75                  80  


Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu Asp Gly Ile His 
                85                  90                  95      


Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe Leu Asp Phe Met 
            100                 105                 110         


Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu Glu Pro His Arg 
        115                 120                 125             


Phe Asn Asp Thr Glu Val Ile Pro Ala Phe Phe Leu Ser Arg Leu Arg 
    130                 135                 140                 


Val His Arg Gly Asp Leu Ser Gln Gly Pro Glu Ala Val Thr Cys 
145                 150                 155                 


<210>  9153
<211>  1281
<212>  DNA
<213>  Homosapiens

<400>  9153
cagacagatt tccccacgca gacgctgtgt gtcacagggg gaatgggcag cgtcactttt     60

tacatccagt catattgtat gaaattgcaa caaattcaaa aagatgccat cgtgggagtg    120

tgatttgtgg tctgcattat gtctggagcc agaagtaagc ttgctctttt cctctgcggc    180

tgttacgtgg ttgccctggg agcccacacc ggggaggaga gcgtggctga ccatcacgag    240

gctgaatatt atgtggctgc cgtgtatgag catccatcca tcctgagtct gaaccctctg    300

gctctcatca gccgccaaga ggccttggag ctcatgaacc agaaccttga catctatgaa    360

cagcaagtga tgactgcagc ccaaaaggat gtacagatta tagtgtttcc agaagatggc    420

attcatggat tcaactttac aagaacatcc atttatccat ttttggactt catgccgtct    480

ccccaggtgg tcaggtggaa cccatgcctg gagcctcacc gcttcaatga cacagaggtg    540

attcctgcct ttttcctcag taggctgagg gtacacagag gtgatctaag tcagggacca    600

gaagctgtga catgttaact aagattgata ggagacctta acatccccaa aatccaaccc    660

aaactcccaa agatccatgt gccacatgtt cattccatta aagaatgtct gacgttacaa    720

ggcagttatt catctatgga tctttccatt tattaattac acaataaata caggaatgta    780

tacttaaacc aaaccaaaag taaaaaaaga aaagttcatc ttcaccacag cctgcacctc    840

atcccatgcc cttgcttaga gaaactgcca tcaacaattt gatgtgcatt cagttgtatt    900

cttttctatg catttcatag ttattgacat cctctttttt tttttttttt ttgagatgga    960

gtcttactct gccacccagg ctggagcgca gtggcgcgat ctcagctcac tgcaagctct   1020

gccttccggg ttcatgccat tctcctgcct cagcctcccg agtagctggg actacaggca   1080

cccaccacca cgcccggcta attttttttg tgtgtgtatt tttagtagag atggggtttc   1140

accatgttag ccaggatggt ctcgatctcc tgaccttgtg atctgtctac ctcggcctgc   1200

caaagtgctg ggattacagg catgagccac tgtgcctggc cttgacatcc tctttttaag   1260

catactatat gcttattcat t                                             1281


<210>  9154
<211>  159
<212>  PRT
<213>  Homosapiens

<400>  9154

Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu Cys Gly Cys Tyr 
1               5                   10                  15      


Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser Val Ala Asp His 
            20                  25                  30          


His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu His Pro Ser Ile 
        35                  40                  45              


Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln Glu Ala Leu Glu 
    50                  55                  60                  


Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln Val Met Thr Ala 
65                  70                  75                  80  


Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu Asp Gly Ile His 
                85                  90                  95      


Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe Leu Asp Phe Met 
            100                 105                 110         


Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu Glu Pro His Arg 
        115                 120                 125             


Phe Asn Asp Thr Glu Val Ile Pro Ala Phe Phe Leu Ser Arg Leu Arg 
    130                 135                 140                 


Val His Arg Gly Asp Leu Ser Gln Gly Pro Glu Ala Val Thr Cys 
145                 150                 155                 


<210>  9155
<211>  1079
<212>  DNA
<213>  Homosapiens

<400>  9155
caatcttggg acaaaggagc cttgtcatag cagtgaccca aggtgcccaa aagatgggag     60

ataccagttc aacacaaatg tcgtgttcag caataatgga acccttgttg accgctaccg    120

taaacacaac ctctactttg aggcagcatt cgatgttcct cttaaagtgg atctcatcac    180

ctttgatacc ccctttgctg gcaggtttgg catcttcaca tgctttgata tattgttctt    240

tgaccctgcc atcagagtcc tcagagacta caaggtgaag catgttgtgt acccaactgc    300

ctggatgaac cagctcccac tcttggcagc aattgagatt cagaaagctt ttgctgttgc    360

ctttggcatc aacgttctgg cagctaatgt ccaccaccca gttctgggga tgacaggaag    420

tggcatacac acccctctgg agtccttttg gtaccatgac atggaaaatc ccaaaagtca    480

ccttataatt gcccaggtgg ccaaaaatcc agtgggtctc attggtgcag agaatgcaac    540

aggtgaaacg gaggggatat ttgagtttca cctgtggggc aacttcagta cttcctatat    600

ctttcctttg tttctgacct cagggatgac cctagaagtc cctgaccagc ttggctggga    660

gaatgaccac tatttcctga ggaaaagtag gctgtcctct gggctggtga cggcggctct    720

ctatgggcgc ttgtatgaga gggactagga aaagtgtgtg gtctgtgggg cggactctgg    780

ccatcatgtt gacagccttg cacttccaca ggctacaagc cctgggacca tctttctgcc    840

ttaagggcag gagcccactt ctgtggcacc agattccacc ctgggaactg tggaaaaagt    900

aggagaggca gattccctca gtgtcttcct cttaaacctc aatcatcgag acattagggg    960

gtattttctg ttcacattta tctttttcaa gccacatctt cctctaacaa atctctcagt   1020

atgcgattgg tctcaagcta aaacaaaaat aaatgtcagt ttatatttta cacatccac    1079


<210>  9156
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  9156

Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe 
1               5                   10                  15      


Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro 
            20                  25                  30          


Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe 
        35                  40                  45              


Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln 
    50                  55                  60                  


Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly 
65                  70                  75                  80  


Glu Thr Glu Gly Ile Phe Glu Phe His Leu Trp Gly Asn Phe Ser Thr 
                85                  90                  95      


Ser Tyr Ile Phe Pro Leu Phe Leu Thr Ser Gly Met Thr Leu Glu Val 
            100                 105                 110         


Pro Asp Gln Leu Gly Trp Glu Asn Asp His Tyr Phe Leu Arg Lys Ser 
        115                 120                 125             


Arg Leu Ser Ser Gly Leu Val Thr Ala Ala Leu Tyr Gly Arg Leu Tyr 
    130                 135                 140                 


Glu Arg Asp 
145         


<210>  9157
<211>  1290
<212>  DNA
<213>  Homosapiens

<400>  9157
caatcttggg acaaaggagc cttgtcatag cagtgaccca aggtgcccaa aagatgggag     60

ataccagttc aacacaaatg tcgtgttcag caataatgga acccttgttg accgctaccg    120

taaacacaac ctctactttg aggcagcatt cgatgttcct cttaaagtgg atctcatcac    180

ctttgatacc ccctttgctg gcaggtttgg catcttcaca tgctttgata tattgttctt    240

tgaccctgcc atcagagtcc tcagagacta caaggtgaag catgttgtgt acccaactgc    300

ctggatgaac cagctcccac tcttggcagc aattgagatt cagaaagctt ttgctgttgc    360

ctttggcatc aacgttctgg cagctaatgt ccaccaccca gttctgggga tgacaggaag    420

tggcatacac acccctctgg agtccttttg gtaccatgac atggaaaatc ccaaaagtca    480

ccttataatt gcccaggtgg ccaaaaatcc agtgggtctc attggtgcag agaatgcaac    540

aggtgaaacg gaggggatat ttgagtttca cctgtggggc aacttcagta cttcctatat    600

ctttcctttg tttctgacct cagggatgac cctagaagtc cctgaccagc ttggctggga    660

gaatgaccac tatttcctga ggaaaagtag gctgtcctct gggctggtga cggcggctct    720

ctatgggcgc ttgtatgaga gggactagga aaagtgtgtg gtctgtgggg cggactctgg    780

ccatcatgtt gacagccttg cacttccaca ggctacaagc cctgggacca tctttctgcc    840

ttaagggcag gagcccactt ctgtggcacc agattccacc ctgggaactg tggaaaaagt    900

aggagaggca gattccctca gtgtcttcct cttaaacctc aatcatcgag acattagggg    960

gtattttctg ttcacattta tctttttcaa gccacatctt cctctaacaa atctctcagt   1020

atgcgattgg tctcaagcta aaacaaaaat aaatgtcagt ttatatttta cacatccaca   1080

aagcagtggc ttggggtttt tttttttttt tttatcttgt tgatcaagtg acacccagga   1140

catgtaaata tttcataagc cttaaacatt tcctgaggta agaaacaagc tctcaaagca   1200

aaagctcaat tagaaatggc ccttgtgggg aaccttccca ttctggtcga ccagaactct   1260

agccagatga aatggcaatg ctagcgccac                                    1290


<210>  9158
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  9158

Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe 
1               5                   10                  15      


Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro 
            20                  25                  30          


Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe 
        35                  40                  45              


Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln 
    50                  55                  60                  


Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly 
65                  70                  75                  80  


Glu Thr Glu Gly Ile Phe Glu Phe His Leu Trp Gly Asn Phe Ser Thr 
                85                  90                  95      


Ser Tyr Ile Phe Pro Leu Phe Leu Thr Ser Gly Met Thr Leu Glu Val 
            100                 105                 110         


Pro Asp Gln Leu Gly Trp Glu Asn Asp His Tyr Phe Leu Arg Lys Ser 
        115                 120                 125             


Arg Leu Ser Ser Gly Leu Val Thr Ala Ala Leu Tyr Gly Arg Leu Tyr 
    130                 135                 140                 


Glu Arg Asp 
145         


<210>  9159
<211>  1018
<212>  DNA
<213>  Homosapiens

<400>  9159
ataccagttc aacacaaatg tcgtgttcag caataatgga acccttgttg accgctaccg     60

taaacacaac ctctactttg aggcagcatt cgatgttcct cttaaagtgg atctcatcac    120

ctttgatacc ccctttgctg gcaggtttgg catcttcaca tgctttgata tattgttctt    180

tgaccctgcc atcagagtcc tcagagacta caaggtgaag catgttgtgt acccaactgc    240

ctggatgaac cagctcccac tcttggcagc aattgagatt cagaaagctt ttgctgttgc    300

ctttggcatc aacgttctgg cagctaatgt ccaccaccca gttctgggga tgacaggaag    360

tggcatacac acccctctgg agtccttttg gtaccatgac atggaaaatc ccaaaagtca    420

ccttataatt gcccaggtgg ccaaaaatcc agtgggtctc attggtgcag agaatgcaac    480

aggtgaaacg gacccatccc atagtaagtt tttaaaaatt ttgtcagtac ttcctatatc    540

tttcctttgt ttctgacctc agggatgacc ctagaagtcc ctgaccagct tggctgggag    600

aatgaccact atttcctgag gaaaagtagg ctgtcctctg ggctggtgac ggcggctctc    660

tatgggcgct tgtatgagag ggactaggaa aagtgtgtgg tctgtggggc ggactctggc    720

catcatgttg acagccttgc acttccacag gctacaagcc ctgggaccat ctttctgcct    780

taagggcagg agcccacttc tgtggcacca gattccaccc tgggaactgt ggaaaaagta    840

ggagaggcag attccctcag tgtcttcctc ttaaacctca atcatcgaga cattaggggg    900

tattttctgt tcacatttat ctttttcaag ccacatcttc ctctaacaaa tctctcagta    960

tgcgattggt ctcaagctaa aacaaaaata aatgtcagtt tatattttac acatccac     1018


<210>  9160
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  9160

Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe 
1               5                   10                  15      


Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro 
            20                  25                  30          


Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe 
        35                  40                  45              


Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln 
    50                  55                  60                  


Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly 
65                  70                  75                  80  


Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser Val Leu 
                85                  90                  95      


Pro Ile Ser Phe Leu Cys Phe 
            100             


<210>  9161
<211>  1229
<212>  DNA
<213>  Homosapiens

<400>  9161
ataccagttc aacacaaatg tcgtgttcag caataatgga acccttgttg accgctaccg     60

taaacacaac ctctactttg aggcagcatt cgatgttcct cttaaagtgg atctcatcac    120

ctttgatacc ccctttgctg gcaggtttgg catcttcaca tgctttgata tattgttctt    180

tgaccctgcc atcagagtcc tcagagacta caaggtgaag catgttgtgt acccaactgc    240

ctggatgaac cagctcccac tcttggcagc aattgagatt cagaaagctt ttgctgttgc    300

ctttggcatc aacgttctgg cagctaatgt ccaccaccca gttctgggga tgacaggaag    360

tggcatacac acccctctgg agtccttttg gtaccatgac atggaaaatc ccaaaagtca    420

ccttataatt gcccaggtgg ccaaaaatcc agtgggtctc attggtgcag agaatgcaac    480

aggtgaaacg gacccatccc atagtaagtt tttaaaaatt ttgtcagtac ttcctatatc    540

tttcctttgt ttctgacctc agggatgacc ctagaagtcc ctgaccagct tggctgggag    600

aatgaccact atttcctgag gaaaagtagg ctgtcctctg ggctggtgac ggcggctctc    660

tatgggcgct tgtatgagag ggactaggaa aagtgtgtgg tctgtggggc ggactctggc    720

catcatgttg acagccttgc acttccacag gctacaagcc ctgggaccat ctttctgcct    780

taagggcagg agcccacttc tgtggcacca gattccaccc tgggaactgt ggaaaaagta    840

ggagaggcag attccctcag tgtcttcctc ttaaacctca atcatcgaga cattaggggg    900

tattttctgt tcacatttat ctttttcaag ccacatcttc ctctaacaaa tctctcagta    960

tgcgattggt ctcaagctaa aacaaaaata aatgtcagtt tatattttac acatccacaa   1020

agcagtggct tggggttttt tttttttttt ttatcttgtt gatcaagtga cacccaggac   1080

atgtaaatat ttcataagcc ttaaacattt cctgaggtaa gaaacaagct ctcaaagcaa   1140

aagctcaatt agaaatggcc cttgtgggga accttcccat tctggtcgac cagaactcta   1200

gccagatgaa atggcaatgc tagcgccac                                     1229


<210>  9162
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  9162

Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe 
1               5                   10                  15      


Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro 
            20                  25                  30          


Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe 
        35                  40                  45              


Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln 
    50                  55                  60                  


Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly 
65                  70                  75                  80  


Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser Val Leu 
                85                  90                  95      


Pro Ile Ser Phe Leu Cys Phe 
            100             


<210>  9163
<211>  993
<212>  DNA
<213>  Homosapiens

<400>  9163
gttcctctta aagtggatct catcaccttt gataccccct ttgctggcag gtttggcatc     60

ttcacatgct ttgatatatt gttctttgac cctgccatca gagtcctcag agactacaag    120

gtgaagcatg ttgtgtaccc aactgcctgg atgaaccagc tcccactctt ggcagcaatt    180

gagattcaga aagcttttgc tgttgccttt ggcatcaacg ttctggcagc taatgtccac    240

cacccagttc tggggatgac aggaagtggc atacacaccc ctctggagtc cttttggtac    300

catgacatgg aaaatcccaa aagtcacctt ataattgccc aggtggccaa aaatccagtg    360

ggtctcattg gtgcagagaa tgcaacaggt gaaacggacc catcccatag taagttttta    420

aaaattttgt caggcgatcc gtactgtgag aaggatgctc aggaagtcca ctgtgatgag    480

gccaccaagt ggaacgtgaa tgctcctccc acatttcact ctgagatgat gtatgacaat    540

ttcaccctga agtccctgac cagcttggct gggagaatga ccactatttc ctgaggaaaa    600

gtaggctgtc ctctgggctg gtgacggcgg ctctctatgg gcgcttgtat gagagggact    660

aggaaaagtg tgtggtctgt ggggcggact ctggccatca tgttgacagc cttgcacttc    720

cacaggctac aagccctggg accatctttc tgccttaagg gcaggagccc acttctgtgg    780

caccagattc caccctggga actgtggaaa aagtaggaga ggcagattcc ctcagtgtct    840

tcctcttaaa cctcaatcat cgagacatta gggggtattt tctgttcaca tttatctttt    900

tcaagccaca tcttcctcta acaaatctct cagtatgcga ttggtctcaa gctaaaacaa    960

aaataaatgt cagtttatat tttacacatc cac                                 993


<210>  9164
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  9164

Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe 
1               5                   10                  15      


Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro 
            20                  25                  30          


Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe 
        35                  40                  45              


Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln 
    50                  55                  60                  


Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly 
65                  70                  75                  80  


Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp 
                85                  90                  95      


Pro Tyr Cys Glu Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr 
            100                 105                 110         


Lys Trp Asn Val Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr 
        115                 120                 125             


Asp Asn Phe Thr Leu Lys Ser Leu Thr Ser Leu Ala Gly Arg Met Thr 
    130                 135                 140                 


Thr Ile Ser 
145         


<210>  9165
<211>  1204
<212>  DNA
<213>  Homosapiens

<400>  9165
gttcctctta aagtggatct catcaccttt gataccccct ttgctggcag gtttggcatc     60

ttcacatgct ttgatatatt gttctttgac cctgccatca gagtcctcag agactacaag    120

gtgaagcatg ttgtgtaccc aactgcctgg atgaaccagc tcccactctt ggcagcaatt    180

gagattcaga aagcttttgc tgttgccttt ggcatcaacg ttctggcagc taatgtccac    240

cacccagttc tggggatgac aggaagtggc atacacaccc ctctggagtc cttttggtac    300

catgacatgg aaaatcccaa aagtcacctt ataattgccc aggtggccaa aaatccagtg    360

ggtctcattg gtgcagagaa tgcaacaggt gaaacggacc catcccatag taagttttta    420

aaaattttgt caggcgatcc gtactgtgag aaggatgctc aggaagtcca ctgtgatgag    480

gccaccaagt ggaacgtgaa tgctcctccc acatttcact ctgagatgat gtatgacaat    540

ttcaccctga agtccctgac cagcttggct gggagaatga ccactatttc ctgaggaaaa    600

gtaggctgtc ctctgggctg gtgacggcgg ctctctatgg gcgcttgtat gagagggact    660

aggaaaagtg tgtggtctgt ggggcggact ctggccatca tgttgacagc cttgcacttc    720

cacaggctac aagccctggg accatctttc tgccttaagg gcaggagccc acttctgtgg    780

caccagattc caccctggga actgtggaaa aagtaggaga ggcagattcc ctcagtgtct    840

tcctcttaaa cctcaatcat cgagacatta gggggtattt tctgttcaca tttatctttt    900

tcaagccaca tcttcctcta acaaatctct cagtatgcga ttggtctcaa gctaaaacaa    960

aaataaatgt cagtttatat tttacacatc cacaaagcag tggcttgggg tttttttttt   1020

tttttttatc ttgttgatca agtgacaccc aggacatgta aatatttcat aagccttaaa   1080

catttcctga ggtaagaaac aagctctcaa agcaaaagct caattagaaa tggcccttgt   1140

ggggaacctt cccattctgg tcgaccagaa ctctagccag atgaaatggc aatgctagcg   1200

ccac                                                                1204


<210>  9166
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  9166

Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe 
1               5                   10                  15      


Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro 
            20                  25                  30          


Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe 
        35                  40                  45              


Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln 
    50                  55                  60                  


Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly 
65                  70                  75                  80  


Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp 
                85                  90                  95      


Pro Tyr Cys Glu Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr 
            100                 105                 110         


Lys Trp Asn Val Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr 
        115                 120                 125             


Asp Asn Phe Thr Leu Lys Ser Leu Thr Ser Leu Ala Gly Arg Met Thr 
    130                 135                 140                 


Thr Ile Ser 
145         


<210>  9167
<211>  1337
<212>  DNA
<213>  Homosapiens

<400>  9167
gctcccaata aggatgtggc tgattgcctg gctctcattt tggccaccat gatgcctgtc     60

tcatcaagta gtcctttatc atccttaaca ttcaatgcca ttaaccgtta taccaacacc    120

tcaaaaacag tcagctttga agctttgccc atcatgagga atgaacctag ctcctattgc    180

agtttcaata acattggagg ggaacaggag tacttataca ctgacgtgga tgagctcaac    240

gactccgatt ctgagaccta ctgagaggct gaggaggagg gagttctcac agtaaagctt    300

caaactgtgc tttttcagga aaaaggcact ttgatattca cgtagaaatt caacctaaga    360

ggaaagatcc cacagtgagc caatgttaag agatctgatg gcattaggag gaagagtttt    420

aaaggcaagt tttacaaaag gaacttctag aatcttgaaa tagacctgac tgaggaaaac    480

acattgatgt cagaattctt tgtggaattg tttaatttgg ttttgcagtg ccaggaacaa    540

ttggggacac tgtgcactct aacctgctta cacaagcaac actattgtaa cagaagaaat    600

aaagacacta gatttaaatt ttatcaataa aattacaact aaatttaaag gcaataaaag    660

tttggtacag taggcattat gtgcacagca aattgcaaaa ggaccaaata actgaaaggt    720

ttttttaata aaatgccatt ttgtggaaac tggagtagat taaatgaaac attacctaaa    780

ccaaactgca atatttctgg aaatgaagct gagatttggt tttaaatgtt gagttttttt    840

gggttttgtt ttttttttaa gaaaacatct gaaagccttc caatgctgta ttaaaccatg    900

agagaaagca gatgtatttt tacatttttt tcttttacag aactatttca aatttccaat    960

ttttatacta ttagaattaa aaaccagctg actgggtgca atacgggtga aaatacttgt   1020

gacatagaca ttcaaatgac ctcctttaac aagacactca tctcaaacaa tgccatttag   1080

ttcaggagat ctctaagtgt agctgtaaat tttggggtta atttggctta tattggacct   1140

tttaaaagaa ataaagtttt ttaatgcaat aaatcaagtg tctgtctctt ttacatgcaa   1200

acttcttttc ccttaaactg tctagcattg aattgacaag ttttttttcc ttttctaata   1260

aaaaaatgac tttttagcaa agttgtttta gacttaaatg aacctatcta tatgggattt   1320

tcaaatatat ttattca                                                  1337


<210>  9168
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  9168

Met Arg Glu Ser Arg Cys Ile Phe Thr Phe Phe Ser Phe Thr Glu Leu 
1               5                   10                  15      


Phe Gln Ile Ser Asn Phe Tyr Thr Ile Arg Ile Lys Asn Gln Leu Thr 
            20                  25                  30          


Gly Cys Asn Thr Gly Glu Asn Thr Cys Asp Ile Asp Ile Gln Met Thr 
        35                  40                  45              


Ser Phe Asn Lys Thr Leu Ile Ser Asn Asn Ala Ile 
    50                  55                  60  


<210>  9169
<211>  4530
<212>  DNA
<213>  Homosapiens

<400>  9169
gtgacctata attataaaaa tgataaatgg atttttttaa acatgtgact attggaatag     60

gtttcattag tcatagaagc aattttaata gttttacaac tgtcaaaact catttctaaa    120

atgatcacaa ctaaaagcca tattatttaa aatgcttttg aactgaaatt ttattataac    180

attgacaata atgtattttt ttccttaatc cacctaccta attttctgaa ggaaagtagt    240

actattttgt gtattctgtg gaaatcaact gtaataatat gttacttgaa actaacaata    300

aatgaggtaa gaagctttat gtgtgtctgt aagccaataa ggtttcttaa agaatcaaaa    360

tttttaataa tgtgagcagc caacctccag atagactgac agagatctta catcagtgtc    420

tctcattgtc ccttgctatt ccattttgag gtttagtaaa gataaaaatc ttagaatatt    480

gttgcccgtt ctgggattag tcagatccct tgaaggtcca aaaattagtc atgatgcttg    540

taagctgttt tcaaagccta ttagaattta tgctactgca gtttacagtt tttaatgtat    600

agtctgtatc tttaccagcc tcattcctta acaacggagg aatgcaattt caatggtaaa    660

atgtttttaa acattgaaaa gaaaagtaac aaaaggattg ggtgaaggta gggacctgtc    720

gatgggacct atggctgagc ttgatgccga gctacacgtt gacaaggtgt gacagtgcac    780

tgcacagagg ttctgctctc cctgccccca tctttgttat taggactagg tttctcgagt    840

ttgtacctct tggtcttcac aagttgacaa aaatgctctt tgacagccag gtgtgtatgt    900

gtatgtgcat gcacatgcac atatgtgtac atgtatcatg ttttttcccc tagacctctg    960

catgttgctg cccgaaatgg gctaacaatg gtggttcagg aacttttggg aaaaggagca   1020

agtgtgcttg cagtagatga aaatggctat accccagctt tggcctgtgc tcccaataag   1080

gatgtggctg attgcctggc tctcattttg gccaccatga tgcctgtctc atcaagtagt   1140

cctttatcat ccttaacatt caatgccatt aaccgttata ccaacacctc aaaaacagtc   1200

agctttgaag ctttgcccat catgaggaat gaacctagct cctattgcag tttcaataac   1260

attggagggg aacaggagta cttatacact gacgtggatg agctcaacga ctccgattct   1320

gagacctact gagaggctga ggaggaggga gttctcacag taaagcttca aactgtgctt   1380

tttcaggaaa aaggcacttt gatattcacg tagaaattca acctaagagg aaagatccca   1440

cagtgagcca atgttaagag atctgatggc attaggagga agagttttaa aggcaagttt   1500

tacaaaagga acttctagaa tcttgaaata gacctgactg aggaaaacac attgatgtca   1560

gaattctttg tggaattgtt taatttggtt ttgcagtgcc aggaacaatt ggggacactg   1620

tgcactctaa cctgcttaca caagcaacac tattgtaaca gaagaaataa agacactaga   1680

tttaaatttt atcaataaaa ttacaactaa atttaaaggc aataaaagtt tggtacagta   1740

ggcattatgt gcacagcaaa ttgcaaaagg accaaataac tgaaaggttt ttttaataaa   1800

atgccatttt gtggaaactg gagtagatta aatgaaacat tacctaaacc aaactgcaat   1860

atttctggaa atgaagctga gatttggttt taaatgttga gtttttttgg gttttgtttt   1920

ttttttaaga aaacatctga aagccttcca atgctgtatt aaaccatgag agaaagcaga   1980

tgtattttta catttttttc ttttacagaa ctatttcaaa tttccaattt ttatactatt   2040

agaattaaaa accagctgac tgggtgcaat acgggtgaaa atacttgtga catagacatt   2100

gagatggatt ggggtcaggc tgttgccctg ttttgaatgg tttgggttta aaatagtact   2160

atttttgttt gaaaatgtaa agaatttcct agaaaaaaat tcatgaaatc aaaaagtaga   2220

ctatttcacc ctattgcagc taagtggtcc tggggcatgg agtcttcaac ctctctatga   2280

atggcacacc ttagtcactt atgttacttt tgtgtcccca ccatgggttg ggggattttt   2340

tgtttattct gatctatgag ttttgaaaaa gtgaataatc aaaaggaaaa taattccttg   2400

ttgttcataa attaagcatc actaaagtct cttgaaaggc atttctgtat tgggcaagat   2460

ttaaaatact aaagccttag gtcctattca tatttaaagt agcatgtttg taacctgtta   2520

ctatttggag agagaagcag ttgcctgcca aattgaagac tacctttcaa atagcaaaag   2580

agagagagaa ggctgatatt tcggctttta aataaagatt tgtgtggttc tgcttttact   2640

gtaactgtca ctttcccagt gaaaatgatt tcatatacat tgagggtctt acaggtatgg   2700

gtaaagttct ataaattgca acaaaatgat acccaatttc attttatcct ttttgtattg   2760

tgaaactgga aactttatga cattgtaaat tatcagctgg tttttctgaa tataaagtgt   2820

gaaaacacag aacagtattt tgatctattt gataattttg tgggtttttt gaagaattaa   2880

tgagcatgta catagaaata gtgactgctt gaatactgta tttacttgca ctctttcagt   2940

acatcaagat tcctgtatat tttagagtat aataaaacac agatgtgagt tgtatttaat   3000

gaataatgta tttgtatctg tgcatattat ctacaaatct ataaagtttc tagggcattg   3060

actactagat tttaagcatt ttttctaaaa tatttacaga aattataaat ctaatccccc   3120

atcttttctt tataatataa agaagtcata atgaaccctt cctaattatt agtagtagga   3180

aggtgaatat gcattttaat gacagtggac tacattttct attgtacctt ttgaaaaaaa   3240

aaaaaatcaa gcagattcta aaagtataca tatgtgtgct ttctctttcc ttttaggaat   3300

tctcttctga attccctgag ggaattttct agaatctcag aattgaaaga gacctgaggt   3360

tcatccagtc tctaacctct taacaaatgc aggagtccct tctacaaggg tgatctttcc   3420

accttgaaca cttccaagtg actctacctc accaagcagt ccattcagtt gttgagcagc   3480

tctaactgtt agaaaggtct tccttagatg gagttgaagc ctccctcccg gtaacttctg   3540

tctttgggcc tgggtctgtc ctccaagaga accctgagaa tgttggaagg atgaatctcg   3600

cacattctgc catgtcttct cttttacagg ctgtttgact tctctgctga agtgatttcc   3660

agaaggactc atttgacaca ctattagatt taccacatct aatgaaatcc aaggtgtagc   3720

tataaagtga caagctgttt ttaatttatc acatacacca gaacttctat cctgcatcac   3780

ttatatgtaa atgatgctgt taccaaaaac attaaggtag ttcttgcgaa tgccacccca   3840

ctaagaaaac tatttcatta cttttgtaat ccatctgtga gagtctgccc cccagcttaa   3900

ccacttcctt tggtctgcac ccaatgaagg gaaaccccaa agtactgtct caaatggtat   3960

ttgaactacg ccagtattgt tggaataagt acattaatta cttgaatgaa tgaacacagc   4020

accgtagaaa tttcctttat ggttacacct tgtatgtcta aagcattcag gccctgttct   4080

gtagtgtttc ttatcctcac acagagtaga aaagcctgtt tgctttattt aacttataca   4140

taaaagatga catctgaaat atctgatgtg tattataata ccagcttctg ctctagaact   4200

actttgggtg aaatggtggt aatagcaaat gacctccttt aacaagacac tcatctcaaa   4260

caatgccatt tagttcagga gatctctaag tgtagctgta aattttgggg ttaatttggc   4320

ttatattgga ccttttaaaa gaaataaagt tttttaatgc aataaatcaa gtgtctgtct   4380

cttttacatg caaacttctt ttcccttaaa ctgtctagca ttgaattgac aagttttttt   4440

tccttttcta ataaaaaaat gactttttag caaagttgtt ttagacttaa atgaacctat   4500

ctatatggga ttttcaaata tatttattca                                    4530


<210>  9170
<211>  133
<212>  PRT
<213>  Homosapiens

<400>  9170

Met Tyr His Val Phe Ser Pro Arg Pro Leu His Val Ala Ala Arg Asn 
1               5                   10                  15      


Gly Leu Thr Met Val Val Gln Glu Leu Leu Gly Lys Gly Ala Ser Val 
            20                  25                  30          


Leu Ala Val Asp Glu Asn Gly Tyr Thr Pro Ala Leu Ala Cys Ala Pro 
        35                  40                  45              


Asn Lys Asp Val Ala Asp Cys Leu Ala Leu Ile Leu Ala Thr Met Met 
    50                  55                  60                  


Pro Val Ser Ser Ser Ser Pro Leu Ser Ser Leu Thr Phe Asn Ala Ile 
65                  70                  75                  80  


Asn Arg Tyr Thr Asn Thr Ser Lys Thr Val Ser Phe Glu Ala Leu Pro 
                85                  90                  95      


Ile Met Arg Asn Glu Pro Ser Ser Tyr Cys Ser Phe Asn Asn Ile Gly 
            100                 105                 110         


Gly Glu Gln Glu Tyr Leu Tyr Thr Asp Val Asp Glu Leu Asn Asp Ser 
        115                 120                 125             


Asp Ser Glu Thr Tyr 
    130             


<210>  9171
<211>  6242
<212>  DNA
<213>  Homosapiens

<400>  9171
gactgtgtct tcacaacgtt agacctctct tcagctgcat tgctggctgc ctagagccct     60

agactaatgt aagagctaga gttaatgcca aagacagcaa atggttgaca cctttacaca    120

gagcagttgc atcttgtagt gaggaagcag ttcaggtact tttgaagcat tctgcagatg    180

ttaatgctcg agacaaaaat tggcaaaccc ctttacatat agctgctgct aataaagctg    240

taaagtgtgc tgaagctttg gtacctcttc tgagtaatgt aaacgtatct gatcgagcag    300

ggaggactgc attacatcat gcagctttca gtggacatgg tgagatggtc aaactactct    360

tgtctagagg tgccaatatt aatgcttttg acaagaaaga taggcgtgct atccattggg    420

cagcatatat gggtcacatt gaagtagtga aattgcttgt gtcgcatgga gctgaagtga    480

catgcaagga taaaaagtct tatacacctc ttcatgcagc agcctctagt ggaatgatca    540

gcgtagtcaa gtaccttcta gatcttggag ttgatatgaa tgaaccaaat gcctatggaa    600

atacacctct tcatgtagcc tgctataatg gacaagatgt tgtagtgaat gaacttatag    660

actgtggtgc tattgtgaat caaaagaatg aaaaaggatt tactcctttg cactttgctg    720

ctgcatcaac acatggagca ttgtgtttag agcttctagt tggcaatggg gccgatgtca    780

atatgaagag taaagatggg aaaaccccac tacacatgac tgctctccac ggtagattct    840

cccgatcaca aaccattatc cagagtggag ctgtaatcga ctgtgaggat aagaatggaa    900

ataccccttt gcacatagca gcacggtatg gccatgagct gctgatcaac actcttatta    960

caagtggtgc tgacactgca aagcgtggca tacatggaat gttccccctc catttggcag   1020

ccttaagcgg cttttcagat tgctgcagaa aacttctttc ttcaggattt gatatagata   1080

ccccagatga ttttggcagg acttgtctac atgcagctgc agctggaggg aatttggagt   1140

gcctaaacct tctgctgaat actggtgcag actttaataa aaaggacaaa tttgggagat   1200

ctccactgca ctacgctgct gccaactgca attaccagtg cctgtttgct cttgtgggat   1260

caggagcaag tgtgaatgac cttgatgaaa gaggctgcac acccctgcac tatgcagcta   1320

catcagacac agatggcaag tgcctggaat acttattaag aaacgatgca aatccaggga   1380

tccgtgataa gcaaggatac aacgcagttc attattcagc tgcttatggt caccgtctat   1440

gtcttcagct gattgcaagt gaaactcctc tagatgtttt aatggaaacc tcaggaacag   1500

acatgctgag tgattcagat aatagagcaa caataagccc tttacacttg gctgcctatc   1560

atggtcacca tcaagcactg gaagtgttgg tacagtcttt gttagatctt gatgtcagaa   1620

atagtagtgg aagaacaccc ctagatcttg cagcttttaa gggccatgtt gaatgtgtgg   1680

atgtactcat taatcaggga gcctcaatct tagtaaaaga ttacattttg aagaggacac   1740

ctattcatgc agcagcaaca aatggtcatt cagaatgctt acggctatta ataggaaatg   1800

cagaaccaca gaatgcagtg gatattcaag atggaaatgg acagacgcct ctgatgctat   1860

ctgttctcaa cgggcacaca gactgtgttt actcattgct gaacaaagga gcaaatgtag   1920

atgccaaaga taagtgggga aggacagcgt tgcatagagg ggcagttaca ggccatgaag   1980

aatgtgtaga tgcattactt caacatggtg ctaagtgctt acttcgggat agcaggggcc   2040

ggacgcctat acacctgtct gctgcctgtg gacacattgg tgttcttgga gcccttttgc   2100

agtcagcagc atctatggat gcaaatccag ccacagcaga caatcatgga tatacggcac   2160

ttcactgggc ttgctacaat ggtcacgaga catgtgtaga actgctttta gaacaggaag   2220

ttttccagaa aacggaagga aatgctttta gtccattgca ttgtgccgtg ataaatgaca   2280

acgaaggtgc tgctgagatg ttaattgata cattaggtgc cagcattgtg aacgccacag   2340

attcaaaagg aagaactcct ctccatgcag ccgccttcac agaccatgta gagtgtttac   2400

agctgctgct cagccataat gctcaagtca attctgtgga ctctacaggg aaaacacctc   2460

ttatgatggc tgcagaaaat ggacaaacaa atacagttga gatgctggtt agcagtgcta   2520

gtgcagaact gactttacaa gataacagta aaaatactgc cctccatttg gcttgtagca   2580

agggtcatga aactagtgcc ttgttaatac tggaaaagat aacagataga aacctcatca   2640

atgcaaccaa cgcagccttg caaacacctc tgcatgttgc tgcccgaaat gggctaacaa   2700

tggtggttca ggaacttttg ggaaaaggag caagtgtgct tgcagtagat gaaaatggct   2760

ataccccagc tttggcctgt gctcccaata aggatgtggc tgattgcctg gctctcattt   2820

tggccaccat gatgcctgtc tcatcaagta gtcctttatc atccttaaca ttcaatgcca   2880

ttaaccgtta taccaacacc tcaaaaacag tcagctttga agctttgccc atcatgagga   2940

atgaacctag ctcctattgc agtttcaata acattggagg ggaacaggag tacttataca   3000

ctgacgtgga tgagctcaac gactccgatt ctgagaccta ctgagaggct gaggaggagg   3060

gagttctcac agtaaagctt caaactgtgc tttttcagga aaaaggcact ttgatattca   3120

cgtagaaatt caacctaaga ggaaagatcc cacagtgagc caatgttaag agatctgatg   3180

gcattaggag gaagagtttt aaaggcaagt tttacaaaag gaacttctag aatcttgaaa   3240

tagacctgac tgaggaaaac acattgatgt cagaattctt tgtggaattg tttaatttgg   3300

ttttgcagtg ccaggaacaa ttggggacac tgtgcactct aacctgctta cacaagcaac   3360

actattgtaa cagaagaaat aaagacacta gatttaaatt ttatcaataa aattacaact   3420

aaatttaaag gcaataaaag tttggtacag taggcattat gtgcacagca aattgcaaaa   3480

ggaccaaata actgaaaggt ttttttaata aaatgccatt ttgtggaaac tggagtagat   3540

taaatgaaac attacctaaa ccaaactgca atatttctgg aaatgaagct gagatttggt   3600

tttaaatgtt gagttttttt gggttttgtt ttttttttaa gaaaacatct gaaagccttc   3660

caatgctgta ttaaaccatg agagaaagca gatgtatttt tacatttttt tcttttacag   3720

aactatttca aatttccaat ttttatacta ttagaattaa aaaccagctg actgggtgca   3780

atacgggtga aaatacttgt gacatagaca ttgagatgga ttggggtcag gctgttgccc   3840

tgttttgaat ggtttgggtt taaaatagta ctatttttgt ttgaaaatgt aaagaatttc   3900

ctagaaaaaa attcatgaaa tcaaaaagta gactatttca ccctattgca gctaagtggt   3960

cctggggcat ggagtcttca acctctctat gaatggcaca ccttagtcac ttatgttact   4020

tttgtgtccc caccatgggt tgggggattt tttgtttatt ctgatctatg agttttgaaa   4080

aagtgaataa tcaaaaggaa aataattcct tgttgttcat aaattaagca tcactaaagt   4140

ctcttgaaag gcatttctgt attgggcaag atttaaaata ctaaagcctt aggtcctatt   4200

catatttaaa gtagcatgtt tgtaacctgt tactatttgg agagagaagc agttgcctgc   4260

caaattgaag actacctttc aaatagcaaa agagagagag aaggctgata tttcggcttt   4320

taaataaaga tttgtgtggt tctgctttta ctgtaactgt cactttccca gtgaaaatga   4380

tttcatatac attgagggtc ttacaggtat gggtaaagtt ctataaattg caacaaaatg   4440

atacccaatt tcattttatc ctttttgtat tgtgaaactg gaaactttat gacattgtaa   4500

attatcagct ggtttttctg aatataaagt gtgaaaacac agaacagtat tttgatctat   4560

ttgataattt tgtgggtttt ttgaagaatt aatgagcatg tacatagaaa tagtgactgc   4620

ttgaatactg tatttacttg cactctttca gtacatcaag attcctgtat attttagagt   4680

ataataaaac acagatgtga gttgtattta atgaataatg tatttgtatc tgtgcatatt   4740

atctacaaat ctataaagtt tctagggcat tgactactag attttaagca ttttttctaa   4800

aatatttaca gaaattataa atctaatccc ccatcttttc tttataatat aaagaagtca   4860

taatgaaccc ttcctaatta ttagtagtag gaaggtgaat atgcatttta atgacagtgg   4920

actacatttt ctattgtacc ttttgaaaaa aaaaaaaatc aagcagattc taaaagtata   4980

catatgtgtg ctttctcttt ccttttagga attctcttct gaattccctg agggaatttt   5040

ctagaatctc agaattgaaa gagacctgag gttcatccag tctctaacct cttaacaaat   5100

gcaggagtcc cttctacaag ggtgatcttt ccaccttgaa cacttccaag tgactctacc   5160

tcaccaagca gtccattcag ttgttgagca gctctaactg ttagaaaggt cttccttaga   5220

tggagttgaa gcctccctcc cggtaacttc tgtctttggg cctgggtctg tcctccaaga   5280

gaaccctgag aatgttggaa ggatgaatct cgcacattct gccatgtctt ctcttttaca   5340

ggctgtttga cttctctgct gaagtgattt ccagaaggac tcatttgaca cactattaga   5400

tttaccacat ctaatgaaat ccaaggtgta gctataaagt gacaagctgt ttttaattta   5460

tcacatacac cagaacttct atcctgcatc acttatatgt aaatgatgct gttaccaaaa   5520

acattaaggt agttcttgcg aatgccaccc cactaagaaa actatttcat tacttttgta   5580

atccatctgt gagagtctgc cccccagctt aaccacttcc tttggtctgc acccaatgaa   5640

gggaaacccc aaagtactgt ctcaaatggt atttgaacta cgccagtatt gttggaataa   5700

gtacattaat tacttgaatg aatgaacaca gcaccgtaga aatttccttt atggttacac   5760

cttgtatgtc taaagcattc aggccctgtt ctgtagtgtt tcttatcctc acacagagta   5820

gaaaagcctg tttgctttat ttaacttata cataaaagat gacatctgaa atatctgatg   5880

tgtattataa taccagcttc tgctctagaa ctactttggg tgaaatggtg gtaatagcaa   5940

atgacctcct ttaacaagac actcatctca aacaatgcca tttagttcag gagatctcta   6000

agtgtagctg taaattttgg ggttaatttg gcttatattg gaccttttaa aagaaataaa   6060

gttttttaat gcaataaatc aagtgtctgt ctcttttaca tgcaaacttc ttttccctta   6120

aactgtctag cattgaattg acaagttttt tttccttttc taataaaaaa atgacttttt   6180

agcaaagttg ttttagactt aaatgaacct atctatatgg gattttcaaa tatatttatt   6240

ca                                                                  6242


<210>  9172
<211>  899
<212>  PRT
<213>  Homosapiens

<400>  9172

Met Val Lys Leu Leu Leu Ser Arg Gly Ala Asn Ile Asn Ala Phe Asp 
1               5                   10                  15      


Lys Lys Asp Arg Arg Ala Ile His Trp Ala Ala Tyr Met Gly His Ile 
            20                  25                  30          


Glu Val Val Lys Leu Leu Val Ser His Gly Ala Glu Val Thr Cys Lys 
        35                  40                  45              


Asp Lys Lys Ser Tyr Thr Pro Leu His Ala Ala Ala Ser Ser Gly Met 
    50                  55                  60                  


Ile Ser Val Val Lys Tyr Leu Leu Asp Leu Gly Val Asp Met Asn Glu 
65                  70                  75                  80  


Pro Asn Ala Tyr Gly Asn Thr Pro Leu His Val Ala Cys Tyr Asn Gly 
                85                  90                  95      


Gln Asp Val Val Val Asn Glu Leu Ile Asp Cys Gly Ala Ile Val Asn 
            100                 105                 110         


Gln Lys Asn Glu Lys Gly Phe Thr Pro Leu His Phe Ala Ala Ala Ser 
        115                 120                 125             


Thr His Gly Ala Leu Cys Leu Glu Leu Leu Val Gly Asn Gly Ala Asp 
    130                 135                 140                 


Val Asn Met Lys Ser Lys Asp Gly Lys Thr Pro Leu His Met Thr Ala 
145                 150                 155                 160 


Leu His Gly Arg Phe Ser Arg Ser Gln Thr Ile Ile Gln Ser Gly Ala 
                165                 170                 175     


Val Ile Asp Cys Glu Asp Lys Asn Gly Asn Thr Pro Leu His Ile Ala 
            180                 185                 190         


Ala Arg Tyr Gly His Glu Leu Leu Ile Asn Thr Leu Ile Thr Ser Gly 
        195                 200                 205             


Ala Asp Thr Ala Lys Arg Gly Ile His Gly Met Phe Pro Leu His Leu 
    210                 215                 220                 


Ala Ala Leu Ser Gly Phe Ser Asp Cys Cys Arg Lys Leu Leu Ser Ser 
225                 230                 235                 240 


Gly Phe Asp Ile Asp Thr Pro Asp Asp Phe Gly Arg Thr Cys Leu His 
                245                 250                 255     


Ala Ala Ala Ala Gly Gly Asn Leu Glu Cys Leu Asn Leu Leu Leu Asn 
            260                 265                 270         


Thr Gly Ala Asp Phe Asn Lys Lys Asp Lys Phe Gly Arg Ser Pro Leu 
        275                 280                 285             


His Tyr Ala Ala Ala Asn Cys Asn Tyr Gln Cys Leu Phe Ala Leu Val 
    290                 295                 300                 


Gly Ser Gly Ala Ser Val Asn Asp Leu Asp Glu Arg Gly Cys Thr Pro 
305                 310                 315                 320 


Leu His Tyr Ala Ala Thr Ser Asp Thr Asp Gly Lys Cys Leu Glu Tyr 
                325                 330                 335     


Leu Leu Arg Asn Asp Ala Asn Pro Gly Ile Arg Asp Lys Gln Gly Tyr 
            340                 345                 350         


Asn Ala Val His Tyr Ser Ala Ala Tyr Gly His Arg Leu Cys Leu Gln 
        355                 360                 365             


Leu Ile Ala Ser Glu Thr Pro Leu Asp Val Leu Met Glu Thr Ser Gly 
    370                 375                 380                 


Thr Asp Met Leu Ser Asp Ser Asp Asn Arg Ala Thr Ile Ser Pro Leu 
385                 390                 395                 400 


His Leu Ala Ala Tyr His Gly His His Gln Ala Leu Glu Val Leu Val 
                405                 410                 415     


Gln Ser Leu Leu Asp Leu Asp Val Arg Asn Ser Ser Gly Arg Thr Pro 
            420                 425                 430         


Leu Asp Leu Ala Ala Phe Lys Gly His Val Glu Cys Val Asp Val Leu 
        435                 440                 445             


Ile Asn Gln Gly Ala Ser Ile Leu Val Lys Asp Tyr Ile Leu Lys Arg 
    450                 455                 460                 


Thr Pro Ile His Ala Ala Ala Thr Asn Gly His Ser Glu Cys Leu Arg 
465                 470                 475                 480 


Leu Leu Ile Gly Asn Ala Glu Pro Gln Asn Ala Val Asp Ile Gln Asp 
                485                 490                 495     


Gly Asn Gly Gln Thr Pro Leu Met Leu Ser Val Leu Asn Gly His Thr 
            500                 505                 510         


Asp Cys Val Tyr Ser Leu Leu Asn Lys Gly Ala Asn Val Asp Ala Lys 
        515                 520                 525             


Asp Lys Trp Gly Arg Thr Ala Leu His Arg Gly Ala Val Thr Gly His 
    530                 535                 540                 


Glu Glu Cys Val Asp Ala Leu Leu Gln His Gly Ala Lys Cys Leu Leu 
545                 550                 555                 560 


Arg Asp Ser Arg Gly Arg Thr Pro Ile His Leu Ser Ala Ala Cys Gly 
                565                 570                 575     


His Ile Gly Val Leu Gly Ala Leu Leu Gln Ser Ala Ala Ser Met Asp 
            580                 585                 590         


Ala Asn Pro Ala Thr Ala Asp Asn His Gly Tyr Thr Ala Leu His Trp 
        595                 600                 605             


Ala Cys Tyr Asn Gly His Glu Thr Cys Val Glu Leu Leu Leu Glu Gln 
    610                 615                 620                 


Glu Val Phe Gln Lys Thr Glu Gly Asn Ala Phe Ser Pro Leu His Cys 
625                 630                 635                 640 


Ala Val Ile Asn Asp Asn Glu Gly Ala Ala Glu Met Leu Ile Asp Thr 
                645                 650                 655     


Leu Gly Ala Ser Ile Val Asn Ala Thr Asp Ser Lys Gly Arg Thr Pro 
            660                 665                 670         


Leu His Ala Ala Ala Phe Thr Asp His Val Glu Cys Leu Gln Leu Leu 
        675                 680                 685             


Leu Ser His Asn Ala Gln Val Asn Ser Val Asp Ser Thr Gly Lys Thr 
    690                 695                 700                 


Pro Leu Met Met Ala Ala Glu Asn Gly Gln Thr Asn Thr Val Glu Met 
705                 710                 715                 720 


Leu Val Ser Ser Ala Ser Ala Glu Leu Thr Leu Gln Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Ala Leu His Leu Ala Cys Ser Lys Gly His Glu Thr Ser Ala 
            740                 745                 750         


Leu Leu Ile Leu Glu Lys Ile Thr Asp Arg Asn Leu Ile Asn Ala Thr 
        755                 760                 765             


Asn Ala Ala Leu Gln Thr Pro Leu His Val Ala Ala Arg Asn Gly Leu 
    770                 775                 780                 


Thr Met Val Val Gln Glu Leu Leu Gly Lys Gly Ala Ser Val Leu Ala 
785                 790                 795                 800 


Val Asp Glu Asn Gly Tyr Thr Pro Ala Leu Ala Cys Ala Pro Asn Lys 
                805                 810                 815     


Asp Val Ala Asp Cys Leu Ala Leu Ile Leu Ala Thr Met Met Pro Val 
            820                 825                 830         


Ser Ser Ser Ser Pro Leu Ser Ser Leu Thr Phe Asn Ala Ile Asn Arg 
        835                 840                 845             


Tyr Thr Asn Thr Ser Lys Thr Val Ser Phe Glu Ala Leu Pro Ile Met 
    850                 855                 860                 


Arg Asn Glu Pro Ser Ser Tyr Cys Ser Phe Asn Asn Ile Gly Gly Glu 
865                 870                 875                 880 


Gln Glu Tyr Leu Tyr Thr Asp Val Asp Glu Leu Asn Asp Ser Asp Ser 
                885                 890                 895     


Glu Thr Tyr 
            


<210>  9173
<211>  4920
<212>  DNA
<213>  Homosapiens

<400>  9173
ccgcgggggc tgccagggta tttcgggaag ggggcgtgag gaggcggcgg cggcagcggc     60

gggtagggca ggcagcagag ggaaggagaa agaaaggaag gaagagggcg gggagtcctc    120

agaggaggag gcgggaccgg ccgggcacct cacctctcgg cggcggcggc ggcggcggcg    180

gcggcgggcg gccggggagg cggcgccgcc ccctgcccgc aggtcttctc agcgcagtcg    240

gccgcggacc cgctggtccc gggcagcggc caaggctact ggggcgggag cagtgggccg    300

gtcggcggcg gcagcggcag cggcggagga ggaggaggct ggagtgggcg cggaggcgac    360

cgccatggcg ttcctcaaac tccgtgacca gccatcactg gtgcaagcta tatttaacgg    420

agatcctgat gaagttcgag cactaatatt taagaaagaa gatgttaact ttcaggacaa    480

tgaaaagcga accccattgc acgccgcagc ttaccttgga gatgcagaaa tcattgaact    540

tcttatttta tctggagcta gagttaatgc caaagacagc aaatggttga cacctttaca    600

cagagcagtt gcatcttgta gtgaggaagc agttcaggta cttttgaagc attctgcaga    660

tgttaatgct cgagacaaaa attggcaaac ccctttacat atagctgctg ctaataaagc    720

tgtaaagtgt gctgaagctt tggtacctct tctgagtaat gtaaacgtat ctgatcgagc    780

agggaggact gcattacatc atgcagcttt cagtggacat ggtgagatgg tcaaactact    840

cttgtctaga ggtgccaata ttaatgcttt tgacaagaaa gataggcgtg ctatccattg    900

ggcagcatat atgggtcaca ttgaagtagt gaaattgctt gtgtcgcatg gagctgaagt    960

gacatgcaag gataaaaagt cttatacacc tcttcatgca gcagcctcta gtggaatgat   1020

cagcgtagtc aagtaccttc tagatcttgg agttgatatg aatgaaccaa atgcctatgg   1080

aaatacacct cttcatgtag cctgctataa tggacaagat gttgtagtga atgaacttat   1140

agactgtggt gctattgtga atcaaaagaa tgaaaaagga tttactcctt tgcactttgc   1200

tgctgcatca acacatggag cattgtgttt agagcttcta gttggcaatg gggccgatgt   1260

caatatgaag agtaaagatg ggaaaacccc actacacatg actgctctcc acggtagatt   1320

ctcccgatca caaaccatta tccagagtgg agctgtaatc gactgtgagg ataagaatgg   1380

aaatacccct ttgcacatag cagcacggta tggccatgag ctgctgatca acactcttat   1440

tacaagtggt gctgacactg caaagcgtgg catacatgga atgttccccc tccatttggc   1500

agccttaagc ggcttttcag attgctgcag aaaacttctt tcttcaggat ttgatataga   1560

taccccagat gattttggca ggacttgtct acatgcagct gcagctggag ggaatttgga   1620

gtgcctaaac cttctgctga atactggtgc agactttaat aaaaaggaca aatttgggag   1680

atctccactg cactacgctg ctgccaactg caattaccag tgcctgtttg ctcttgtggg   1740

atcaggagca agtgtgaatg accttgatga aagaggctgc acacccctgc actatgcagc   1800

tacatcagac acagatggca agtgcctgga atacttatta agaaacgatg caaatccagg   1860

gatccgtgat aagcaaggat acaacgcagt tcattattca gctgcttatg gtcaccgtct   1920

atgtcttcag ctgattgcaa gtgaaactcc tctagatgtt ttaatggaaa cctcaggaac   1980

agacatgctg agtgattcag ataatagagc aacaataagc cctttacact tggctgccta   2040

tcatggtcac catcaagcac tggaagtgtt ggtacagtct ttgttagatc ttgatgtcag   2100

aaatagtagt ggaagaacac ccctagatct tgcagctttt aagggccatg ttgaatgtgt   2160

ggatgtactc attaatcagg gagcctcaat cttagtaaaa gattacattt tgaagaggac   2220

acctattcat gcagcagcaa caaatggtca ttcagaatgc ttacggctat taataggaaa   2280

tgcagaacca cagaatgcag tggatattca agatggaaat ggacagacgc ctctgatgct   2340

atctgttctc aacgggcaca cagactgtgt ttactcattg ctgaacaaag gagcaaatgt   2400

agatgccaaa gataagtggg gaaggacagc gttgcataga ggggcagtta caggccatga   2460

agaatgtgta gatgcattac ttcaacatgg tgctaagtgc ttacttcggg atagcagggg   2520

ccggacgcct atacacctgt ctgctgcctg tggacacatt ggtgttcttg gagccctttt   2580

gcagtcagca gcatctatgg atgcaaatcc agccacagca gacaatcatg gatatacggc   2640

acttcactgg gcttgctaca atggtcacga gacatgtgta gaactgcttt tagaacagga   2700

agttttccag aaaacggaag gaaatgcttt tagtccattg cattgtgccg tgataaatga   2760

caacgaaggt gctgctgaga tgttaattga tacattaggt gccagcattg tgaacgccac   2820

agattcaaaa ggaagaactc ctctccatgc agccgccttc acagaccatg tagagtgttt   2880

acagctgctg ctcagccata atgctcaagt caattctgtg gactctacag ggaaaacacc   2940

tcttatgatg gctgcagaaa atggacaaac aaatacagtt gagatgctgg ttagcagtgc   3000

tagtgcagaa ctgactttac aagataacag taaaaatact gccctccatt tggcttgtag   3060

caagggtcat gaaactagtg ccttgttaat actggaaaag ataacagata gaaacctcat   3120

caatgcaacc aacgcagcct tgcaaacacc tctgcatgtt gctgcccgaa atgggctaac   3180

aatggtggtt caggaacttt tgggaaaagg agcaagtgtg cttgcagtag atgaaaatgg   3240

ctatacccca gctttggcct gtgctcccaa taaggatgtg gctgattgcc tggctctcat   3300

tttggccacc atgatgcctg tctcatcaag tagtccttta tcatccttaa cattcaatgc   3360

cattaaccgt tataccaaca cctcaaaaac agtcagcttt gaagctttgc ccatcatgag   3420

gaatgaacct agctcctatt gcagtttcaa taacattgga ggggaacagg agtacttata   3480

cactgacgtg gatgagctca acgactccga ttctgagacc tactgagagg ctgaggagga   3540

gggagttctc acagtaaagc ttcaaactgt gctttttcag gaaaaaggca ctttgatatt   3600

cacgtagaaa ttcaacctaa gaggaaagat cccacagtga gccaatgtta agagatctga   3660

tggcattagg aggaagagtt ttaaaggaat tctcttctga attccctgag ggaattttct   3720

agaatctcag aattgaaaga gacctgaggt tcatccagtc tctaacctct taacaaatgc   3780

aggagtccct tctacaaggg tgatctttcc accttgaaca cttccaagtg actctacctc   3840

accaagcagt ccattcagtt gttgagcagc tctaactgtt agaaaggtct tccttagatg   3900

gagttgaagc ctccctcccg gtaacttctg tctttgggcc tgggtctgtc ctccaagaga   3960

accctgagaa tgttggaagg atgaatctcg cacattctgc catgtcttct cttttacagg   4020

ctgtttgact tctctgctga agtgatttcc agaaggactc atttgacaca ctattagatt   4080

taccacatct aatgaaatcc aaggtgtagc tataaagtga caagctgttt ttaatttatc   4140

acatacacca gaacttctat cctgcatcac ttatatgtaa atgatgctgt taccaaaaac   4200

attaaggtag ttcttgcgaa tgccacccca ctaagaaaac tatttcatta cttttgtaat   4260

ccatctgtga gagtctgccc cccagcttaa ccacttcctt tggtctgcac ccaatgaagg   4320

gaaaccccaa agtactgtct caaatggtat ttgaactacg ccagtattgt tggaataagt   4380

acattaatta cttgaatgaa tgaacacagc accgtagaaa tttcctttat ggttacacct   4440

tgtatgtcta aagcattcag gccctgttct gtagtgtttc ttatcctcac acagagtaga   4500

aaagcctgtt tgctttattt aacttataca taaaagatga catctgaaat atctgatgtg   4560

tattataata ccagcttctg ctctagaact actttgggtg aaatggtggt aatagcaaat   4620

gacctccttt aacaagacac tcatctcaaa caatgccatt tagttcagga gatctctaag   4680

tgtagctgta aattttgggg ttaatttggc ttatattgga ccttttaaaa gaaataaagt   4740

tttttaatgc aataaatcaa gtgtctgtct cttttacatg caaacttctt ttcccttaaa   4800

ctgtctagca ttgaattgac aagttttttt tccttttcta ataaaaaaat gactttttag   4860

caaagttgtt ttagacttaa atgaacctat ctatatggga ttttcaaata tatttattca   4920


<210>  9174
<211>  1053
<212>  PRT
<213>  Homosapiens

<400>  9174

Met Ala Phe Leu Lys Leu Arg Asp Gln Pro Ser Leu Val Gln Ala Ile 
1               5                   10                  15      


Phe Asn Gly Asp Pro Asp Glu Val Arg Ala Leu Ile Phe Lys Lys Glu 
            20                  25                  30          


Asp Val Asn Phe Gln Asp Asn Glu Lys Arg Thr Pro Leu His Ala Ala 
        35                  40                  45              


Ala Tyr Leu Gly Asp Ala Glu Ile Ile Glu Leu Leu Ile Leu Ser Gly 
    50                  55                  60                  


Ala Arg Val Asn Ala Lys Asp Ser Lys Trp Leu Thr Pro Leu His Arg 
65                  70                  75                  80  


Ala Val Ala Ser Cys Ser Glu Glu Ala Val Gln Val Leu Leu Lys His 
                85                  90                  95      


Ser Ala Asp Val Asn Ala Arg Asp Lys Asn Trp Gln Thr Pro Leu His 
            100                 105                 110         


Ile Ala Ala Ala Asn Lys Ala Val Lys Cys Ala Glu Ala Leu Val Pro 
        115                 120                 125             


Leu Leu Ser Asn Val Asn Val Ser Asp Arg Ala Gly Arg Thr Ala Leu 
    130                 135                 140                 


His His Ala Ala Phe Ser Gly His Gly Glu Met Val Lys Leu Leu Leu 
145                 150                 155                 160 


Ser Arg Gly Ala Asn Ile Asn Ala Phe Asp Lys Lys Asp Arg Arg Ala 
                165                 170                 175     


Ile His Trp Ala Ala Tyr Met Gly His Ile Glu Val Val Lys Leu Leu 
            180                 185                 190         


Val Ser His Gly Ala Glu Val Thr Cys Lys Asp Lys Lys Ser Tyr Thr 
        195                 200                 205             


Pro Leu His Ala Ala Ala Ser Ser Gly Met Ile Ser Val Val Lys Tyr 
    210                 215                 220                 


Leu Leu Asp Leu Gly Val Asp Met Asn Glu Pro Asn Ala Tyr Gly Asn 
225                 230                 235                 240 


Thr Pro Leu His Val Ala Cys Tyr Asn Gly Gln Asp Val Val Val Asn 
                245                 250                 255     


Glu Leu Ile Asp Cys Gly Ala Ile Val Asn Gln Lys Asn Glu Lys Gly 
            260                 265                 270         


Phe Thr Pro Leu His Phe Ala Ala Ala Ser Thr His Gly Ala Leu Cys 
        275                 280                 285             


Leu Glu Leu Leu Val Gly Asn Gly Ala Asp Val Asn Met Lys Ser Lys 
    290                 295                 300                 


Asp Gly Lys Thr Pro Leu His Met Thr Ala Leu His Gly Arg Phe Ser 
305                 310                 315                 320 


Arg Ser Gln Thr Ile Ile Gln Ser Gly Ala Val Ile Asp Cys Glu Asp 
                325                 330                 335     


Lys Asn Gly Asn Thr Pro Leu His Ile Ala Ala Arg Tyr Gly His Glu 
            340                 345                 350         


Leu Leu Ile Asn Thr Leu Ile Thr Ser Gly Ala Asp Thr Ala Lys Arg 
        355                 360                 365             


Gly Ile His Gly Met Phe Pro Leu His Leu Ala Ala Leu Ser Gly Phe 
    370                 375                 380                 


Ser Asp Cys Cys Arg Lys Leu Leu Ser Ser Gly Phe Asp Ile Asp Thr 
385                 390                 395                 400 


Pro Asp Asp Phe Gly Arg Thr Cys Leu His Ala Ala Ala Ala Gly Gly 
                405                 410                 415     


Asn Leu Glu Cys Leu Asn Leu Leu Leu Asn Thr Gly Ala Asp Phe Asn 
            420                 425                 430         


Lys Lys Asp Lys Phe Gly Arg Ser Pro Leu His Tyr Ala Ala Ala Asn 
        435                 440                 445             


Cys Asn Tyr Gln Cys Leu Phe Ala Leu Val Gly Ser Gly Ala Ser Val 
    450                 455                 460                 


Asn Asp Leu Asp Glu Arg Gly Cys Thr Pro Leu His Tyr Ala Ala Thr 
465                 470                 475                 480 


Ser Asp Thr Asp Gly Lys Cys Leu Glu Tyr Leu Leu Arg Asn Asp Ala 
                485                 490                 495     


Asn Pro Gly Ile Arg Asp Lys Gln Gly Tyr Asn Ala Val His Tyr Ser 
            500                 505                 510         


Ala Ala Tyr Gly His Arg Leu Cys Leu Gln Leu Ile Ala Ser Glu Thr 
        515                 520                 525             


Pro Leu Asp Val Leu Met Glu Thr Ser Gly Thr Asp Met Leu Ser Asp 
    530                 535                 540                 


Ser Asp Asn Arg Ala Thr Ile Ser Pro Leu His Leu Ala Ala Tyr His 
545                 550                 555                 560 


Gly His His Gln Ala Leu Glu Val Leu Val Gln Ser Leu Leu Asp Leu 
                565                 570                 575     


Asp Val Arg Asn Ser Ser Gly Arg Thr Pro Leu Asp Leu Ala Ala Phe 
            580                 585                 590         


Lys Gly His Val Glu Cys Val Asp Val Leu Ile Asn Gln Gly Ala Ser 
        595                 600                 605             


Ile Leu Val Lys Asp Tyr Ile Leu Lys Arg Thr Pro Ile His Ala Ala 
    610                 615                 620                 


Ala Thr Asn Gly His Ser Glu Cys Leu Arg Leu Leu Ile Gly Asn Ala 
625                 630                 635                 640 


Glu Pro Gln Asn Ala Val Asp Ile Gln Asp Gly Asn Gly Gln Thr Pro 
                645                 650                 655     


Leu Met Leu Ser Val Leu Asn Gly His Thr Asp Cys Val Tyr Ser Leu 
            660                 665                 670         


Leu Asn Lys Gly Ala Asn Val Asp Ala Lys Asp Lys Trp Gly Arg Thr 
        675                 680                 685             


Ala Leu His Arg Gly Ala Val Thr Gly His Glu Glu Cys Val Asp Ala 
    690                 695                 700                 


Leu Leu Gln His Gly Ala Lys Cys Leu Leu Arg Asp Ser Arg Gly Arg 
705                 710                 715                 720 


Thr Pro Ile His Leu Ser Ala Ala Cys Gly His Ile Gly Val Leu Gly 
                725                 730                 735     


Ala Leu Leu Gln Ser Ala Ala Ser Met Asp Ala Asn Pro Ala Thr Ala 
            740                 745                 750         


Asp Asn His Gly Tyr Thr Ala Leu His Trp Ala Cys Tyr Asn Gly His 
        755                 760                 765             


Glu Thr Cys Val Glu Leu Leu Leu Glu Gln Glu Val Phe Gln Lys Thr 
    770                 775                 780                 


Glu Gly Asn Ala Phe Ser Pro Leu His Cys Ala Val Ile Asn Asp Asn 
785                 790                 795                 800 


Glu Gly Ala Ala Glu Met Leu Ile Asp Thr Leu Gly Ala Ser Ile Val 
                805                 810                 815     


Asn Ala Thr Asp Ser Lys Gly Arg Thr Pro Leu His Ala Ala Ala Phe 
            820                 825                 830         


Thr Asp His Val Glu Cys Leu Gln Leu Leu Leu Ser His Asn Ala Gln 
        835                 840                 845             


Val Asn Ser Val Asp Ser Thr Gly Lys Thr Pro Leu Met Met Ala Ala 
    850                 855                 860                 


Glu Asn Gly Gln Thr Asn Thr Val Glu Met Leu Val Ser Ser Ala Ser 
865                 870                 875                 880 


Ala Glu Leu Thr Leu Gln Asp Asn Ser Lys Asn Thr Ala Leu His Leu 
                885                 890                 895     


Ala Cys Ser Lys Gly His Glu Thr Ser Ala Leu Leu Ile Leu Glu Lys 
            900                 905                 910         


Ile Thr Asp Arg Asn Leu Ile Asn Ala Thr Asn Ala Ala Leu Gln Thr 
        915                 920                 925             


Pro Leu His Val Ala Ala Arg Asn Gly Leu Thr Met Val Val Gln Glu 
    930                 935                 940                 


Leu Leu Gly Lys Gly Ala Ser Val Leu Ala Val Asp Glu Asn Gly Tyr 
945                 950                 955                 960 


Thr Pro Ala Leu Ala Cys Ala Pro Asn Lys Asp Val Ala Asp Cys Leu 
                965                 970                 975     


Ala Leu Ile Leu Ala Thr Met Met Pro Val Ser Ser Ser Ser Pro Leu 
            980                 985                 990         


Ser Ser Leu Thr Phe Asn Ala Ile  Asn Arg Tyr Thr Asn  Thr Ser Lys 
        995                 1000                 1005             


Thr Val  Ser Phe Glu Ala Leu  Pro Ile Met Arg Asn  Glu Pro Ser 
    1010                 1015                 1020             


Ser Tyr  Cys Ser Phe Asn Asn  Ile Gly Gly Glu Gln  Glu Tyr Leu 
    1025                 1030                 1035             


Tyr Thr  Asp Val Asp Glu Leu  Asn Asp Ser Asp Ser  Glu Thr Tyr 
    1040                 1045                 1050             


<210>  9175
<211>  4363
<212>  DNA
<213>  Homosapiens

<400>  9175
gtgacctata attataaaaa tgataaatgg atttttttaa acatgtgact attggaatag     60

gtttcattag tcatagaagc aattttaata gttttacaac tgtcaaaact catttctaaa    120

atgatcacaa ctaaaagcca tattatttaa aatgcttttg aactgaaatt ttattataac    180

attgacaata atgtattttt ttccttaatc cacctaccta attttctgaa ggaaagtagt    240

actattttgt gtattctgtg gaaatcaact gtaataatat gttacttgaa actaacaata    300

aatgaggtaa gaagctttat gtgtgtctgt aagccaataa ggtttcttaa agaatcaaaa    360

tttttaataa tgtgagcagc caacctccag atagactgac agagatctta catcagtgtc    420

tctcattgtc ccttgctatt ccattttgag gtttagtaaa gataaaaatc ttagaatatt    480

gttgcccgtt ctgggattag tcagatccct tgaaggtcca aaaattagtc atgatgcttg    540

taagctgttt tcaaagccta ttagaattta tgctactgca gtttacagtt tttaatgtat    600

agtctgtatc tttaccagcc tcattcctta acaacggagg aatgcaattt caatggtaaa    660

atgtttttaa acattgaaaa gaaaagtaac aaaaggattg ggtgaaggta gggacctgtc    720

gatgggacct atggctgagc ttgatgccga gctacacgtt gacaaggtgt gacagtgcac    780

tgcacagagg ttctgctctc cctgccccca tctttgttat taggactagg tttctcgagt    840

ttgtacctct tggtcttcac aagttgacaa aaatgctctt tgacagccag gtgtgtatgt    900

gtatgtgcat gcacatgcac atatgtgtac atgtatcatg ttttttcccc tagacctctg    960

catgttgctg cccgaaatgg gctaacaatg gtggttcagg aacttttggg aaaaggagca   1020

agtgtgcttg cagtagatga aaatggctat accccagctt tggcctgtgc tcccaataag   1080

gatgtggctg attgcctggc tctcattttg gccaccatga tgcctgtctc atcaagtagt   1140

cctttatcat ccttaacatt caatgccatt aaccgttata ccaacacctc aaaaacagtc   1200

agctttgaag ctttgcccat catgaggaat gaacctagct cctattgcag tttcaataac   1260

attggagggg aacaggagta cttatacact gacgtggatg agctcaacga ctccgattct   1320

gagacctact gagaggctga ggaggaggga gttctcacag taaagcttca aactgtgctt   1380

tttcaggaaa aaggcacttt gatattcacg tagaaattca acctaagagg aaagatccca   1440

cagtgagcca atgttaagag atctgatggc attaggagga agagttttaa aggcaagttt   1500

tacaaaagga acttctagaa tcttgaaata gacctgactg aggaaaacac attgatgtca   1560

gaattctttg tggaattgtt taatttggtt ttgcagtgcc aggaacaatt ggggacactg   1620

tgcactctaa cctgcttaca caagcaacac tattgtaaca gaagaaataa agacactaga   1680

tttaaatttt atcaataaaa ttacaactaa atttaaaggc aataaaagtt tggtacagta   1740

ggcattatgt gcacagcaaa ttgcaaaagg accaaataac tgaaaggttt ttttaataaa   1800

atgccatttt gtggaaactg gagtagatta aatgaaacat tacctaaacc aaactgcaat   1860

atttctggaa atgaagctga gatttggttt taaatgttga gtttttttgg gttttgtttt   1920

ttttttaaga aaacatctga aagccttcca atgctgtatt aaaccatgag agaaagcaga   1980

tgtattttta catttttttc ttttacagaa ctatttcaaa tttccaattt ttatactatt   2040

agaattaaaa accagctgac tgggtgcaat acgggtgaaa atacttgtga catagacatt   2100

gagatggatt ggggtcaggc tgttgccctg ttttgaatgg tttgggttta aaatagtact   2160

atttttgttt gaaaatgtaa agaatttcct agaaaaaaat tcatgaaatc aaaaagtaga   2220

ctatttcacc ctattgcagc taagtggtcc tggggcatgg agtcttcaac ctctctatga   2280

atggcacacc ttagtcactt atgttacttt tgtgtcccca ccatgggttg ggggattttt   2340

tgtttattct gatctatgag ttttgaaaaa gtgaataatc aaaaggaaaa taattccttg   2400

ttgttcataa attaagcatc actaaagtct cttgaaaggc atttctgtat tgggcaagat   2460

ttaaaatact aaagccttag gtcctattca tatttaaagt agcatgtttg taacctgtta   2520

ctatttggag agagaagcag ttgcctgcca aattgaagac tacctttcaa atagcaaaag   2580

agagagagaa ggctgatatt tcggctttta aataaagatt tgtgtggttc tgcttttact   2640

gtaactgtca ctttcccagt gaaaatgatt tcatatacat tgagggtctt acaggtatgg   2700

gtaaagttct ataaattgca acaaaatgat acccaatttc attttatcct ttttgtattg   2760

tgaaactgga aactttatga cattgtaaat tatcagctgg tttttctgaa tataaagtgt   2820

gaaaacacag aacagtattt tgatctattt gataattttg tgggtttttt gaagaattaa   2880

tgagcatgta catagaaata gtgactgctt gaatactgta tttacttgca ctctttcagt   2940

acatcaagat tcctgtatat tttagagtat aataaaacac agatgtgagt tgtatttaat   3000

gaataatgta tttgtatctg tgcatattat ctacaaatct ataaagtttc tagggcattg   3060

actactagat tttaagcatt ttttctaaaa tatttacaga aattataaat ctaatccccc   3120

atcttttctt tataatataa agaagtcata atgaaccctt cctaattatt agtagtagga   3180

aggtgaatat gcattttaat gacagtggac tacattttct attgtacctt ttgaaaaaaa   3240

aaaaaatcaa gcagattcta aaagtataca tatgtgtgct ttctctttcc ttttaggaat   3300

tctcttctga attccctgag ggaattttct agaatctcag aattgaaaga gacctgaggt   3360

tcatccagtc tctaacctct taacaaatgc aggagtccct tctacaaggg tgatctttcc   3420

accttgaaca cttccaagtg actctacctc accaagcagt ccattcagtt gttgagcagc   3480

tctaactgtt agaaaggtct tccttagatg gagttgaagc ctccctcccg gtaacttctg   3540

tctttgggcc tgggtctgtc ctccaagaga accctgagaa tgttggaagg atgaatctcg   3600

cacattctgc catgtcttct cttttacagg ctgtttgact tctctgctga agtgatttcc   3660

agaaggactc atttgacaca ctattagatt taccacatct aatgaaatcc aaggtgtagc   3720

tataaagtga caagctgttt ttaatttatc acatacacca gaacttctat cctgcatcac   3780

ttatatgtaa atgatgctgt taccaaaaac attaaggtag ttcttgcgaa tgccacccca   3840

ctaagaaaac tatttcatta cttttgtaat ccatctgtga gagtctgccc cccagcttaa   3900

ccacttcctt tggtctgcac ccaatgaagg gaaaccccaa agtactgtct caaatggtat   3960

ttgaactacg ccagtattgt tggaataagt acattaatta cttgaatgaa tgaacacagc   4020

accgtagaaa tttcctttat ggttacacct tgtatgtcta aagcattcag gccctgttct   4080

gtagtgtttc ttatcctcac acagagtaga aaagcctgtt tgctttattt aacttataca   4140

taaaagatga catctgaaat atctgatgtg tattataata ccagcttctg ctctagaact   4200

actttgggtg aaatggtggt aatagcaaat gacctccttt aacaagacac tcatctcaaa   4260

caatgccatt tagttcagga gatctctaag tgtagctgta aattttgggg ttaatttggc   4320

ttatattgga ccttttaaaa gaaataaagt tttttaatgc aat                     4363


<210>  9176
<211>  133
<212>  PRT
<213>  Homosapiens

<400>  9176

Met Tyr His Val Phe Ser Pro Arg Pro Leu His Val Ala Ala Arg Asn 
1               5                   10                  15      


Gly Leu Thr Met Val Val Gln Glu Leu Leu Gly Lys Gly Ala Ser Val 
            20                  25                  30          


Leu Ala Val Asp Glu Asn Gly Tyr Thr Pro Ala Leu Ala Cys Ala Pro 
        35                  40                  45              


Asn Lys Asp Val Ala Asp Cys Leu Ala Leu Ile Leu Ala Thr Met Met 
    50                  55                  60                  


Pro Val Ser Ser Ser Ser Pro Leu Ser Ser Leu Thr Phe Asn Ala Ile 
65                  70                  75                  80  


Asn Arg Tyr Thr Asn Thr Ser Lys Thr Val Ser Phe Glu Ala Leu Pro 
                85                  90                  95      


Ile Met Arg Asn Glu Pro Ser Ser Tyr Cys Ser Phe Asn Asn Ile Gly 
            100                 105                 110         


Gly Glu Gln Glu Tyr Leu Tyr Thr Asp Val Asp Glu Leu Asn Asp Ser 
        115                 120                 125             


Asp Ser Glu Thr Tyr 
    130             


<210>  9177
<211>  6075
<212>  DNA
<213>  Homosapiens

<400>  9177
gactgtgtct tcacaacgtt agacctctct tcagctgcat tgctggctgc ctagagccct     60

agactaatgt aagagctaga gttaatgcca aagacagcaa atggttgaca cctttacaca    120

gagcagttgc atcttgtagt gaggaagcag ttcaggtact tttgaagcat tctgcagatg    180

ttaatgctcg agacaaaaat tggcaaaccc ctttacatat agctgctgct aataaagctg    240

taaagtgtgc tgaagctttg gtacctcttc tgagtaatgt aaacgtatct gatcgagcag    300

ggaggactgc attacatcat gcagctttca gtggacatgg tgagatggtc aaactactct    360

tgtctagagg tgccaatatt aatgcttttg acaagaaaga taggcgtgct atccattggg    420

cagcatatat gggtcacatt gaagtagtga aattgcttgt gtcgcatgga gctgaagtga    480

catgcaagga taaaaagtct tatacacctc ttcatgcagc agcctctagt ggaatgatca    540

gcgtagtcaa gtaccttcta gatcttggag ttgatatgaa tgaaccaaat gcctatggaa    600

atacacctct tcatgtagcc tgctataatg gacaagatgt tgtagtgaat gaacttatag    660

actgtggtgc tattgtgaat caaaagaatg aaaaaggatt tactcctttg cactttgctg    720

ctgcatcaac acatggagca ttgtgtttag agcttctagt tggcaatggg gccgatgtca    780

atatgaagag taaagatggg aaaaccccac tacacatgac tgctctccac ggtagattct    840

cccgatcaca aaccattatc cagagtggag ctgtaatcga ctgtgaggat aagaatggaa    900

ataccccttt gcacatagca gcacggtatg gccatgagct gctgatcaac actcttatta    960

caagtggtgc tgacactgca aagcgtggca tacatggaat gttccccctc catttggcag   1020

ccttaagcgg cttttcagat tgctgcagaa aacttctttc ttcaggattt gatatagata   1080

ccccagatga ttttggcagg acttgtctac atgcagctgc agctggaggg aatttggagt   1140

gcctaaacct tctgctgaat actggtgcag actttaataa aaaggacaaa tttgggagat   1200

ctccactgca ctacgctgct gccaactgca attaccagtg cctgtttgct cttgtgggat   1260

caggagcaag tgtgaatgac cttgatgaaa gaggctgcac acccctgcac tatgcagcta   1320

catcagacac agatggcaag tgcctggaat acttattaag aaacgatgca aatccaggga   1380

tccgtgataa gcaaggatac aacgcagttc attattcagc tgcttatggt caccgtctat   1440

gtcttcagct gattgcaagt gaaactcctc tagatgtttt aatggaaacc tcaggaacag   1500

acatgctgag tgattcagat aatagagcaa caataagccc tttacacttg gctgcctatc   1560

atggtcacca tcaagcactg gaagtgttgg tacagtcttt gttagatctt gatgtcagaa   1620

atagtagtgg aagaacaccc ctagatcttg cagcttttaa gggccatgtt gaatgtgtgg   1680

atgtactcat taatcaggga gcctcaatct tagtaaaaga ttacattttg aagaggacac   1740

ctattcatgc agcagcaaca aatggtcatt cagaatgctt acggctatta ataggaaatg   1800

cagaaccaca gaatgcagtg gatattcaag atggaaatgg acagacgcct ctgatgctat   1860

ctgttctcaa cgggcacaca gactgtgttt actcattgct gaacaaagga gcaaatgtag   1920

atgccaaaga taagtgggga aggacagcgt tgcatagagg ggcagttaca ggccatgaag   1980

aatgtgtaga tgcattactt caacatggtg ctaagtgctt acttcgggat agcaggggcc   2040

ggacgcctat acacctgtct gctgcctgtg gacacattgg tgttcttgga gcccttttgc   2100

agtcagcagc atctatggat gcaaatccag ccacagcaga caatcatgga tatacggcac   2160

ttcactgggc ttgctacaat ggtcacgaga catgtgtaga actgctttta gaacaggaag   2220

ttttccagaa aacggaagga aatgctttta gtccattgca ttgtgccgtg ataaatgaca   2280

acgaaggtgc tgctgagatg ttaattgata cattaggtgc cagcattgtg aacgccacag   2340

attcaaaagg aagaactcct ctccatgcag ccgccttcac agaccatgta gagtgtttac   2400

agctgctgct cagccataat gctcaagtca attctgtgga ctctacaggg aaaacacctc   2460

ttatgatggc tgcagaaaat ggacaaacaa atacagttga gatgctggtt agcagtgcta   2520

gtgcagaact gactttacaa gataacagta aaaatactgc cctccatttg gcttgtagca   2580

agggtcatga aactagtgcc ttgttaatac tggaaaagat aacagataga aacctcatca   2640

atgcaaccaa cgcagccttg caaacacctc tgcatgttgc tgcccgaaat gggctaacaa   2700

tggtggttca ggaacttttg ggaaaaggag caagtgtgct tgcagtagat gaaaatggct   2760

ataccccagc tttggcctgt gctcccaata aggatgtggc tgattgcctg gctctcattt   2820

tggccaccat gatgcctgtc tcatcaagta gtcctttatc atccttaaca ttcaatgcca   2880

ttaaccgtta taccaacacc tcaaaaacag tcagctttga agctttgccc atcatgagga   2940

atgaacctag ctcctattgc agtttcaata acattggagg ggaacaggag tacttataca   3000

ctgacgtgga tgagctcaac gactccgatt ctgagaccta ctgagaggct gaggaggagg   3060

gagttctcac agtaaagctt caaactgtgc tttttcagga aaaaggcact ttgatattca   3120

cgtagaaatt caacctaaga ggaaagatcc cacagtgagc caatgttaag agatctgatg   3180

gcattaggag gaagagtttt aaaggcaagt tttacaaaag gaacttctag aatcttgaaa   3240

tagacctgac tgaggaaaac acattgatgt cagaattctt tgtggaattg tttaatttgg   3300

ttttgcagtg ccaggaacaa ttggggacac tgtgcactct aacctgctta cacaagcaac   3360

actattgtaa cagaagaaat aaagacacta gatttaaatt ttatcaataa aattacaact   3420

aaatttaaag gcaataaaag tttggtacag taggcattat gtgcacagca aattgcaaaa   3480

ggaccaaata actgaaaggt ttttttaata aaatgccatt ttgtggaaac tggagtagat   3540

taaatgaaac attacctaaa ccaaactgca atatttctgg aaatgaagct gagatttggt   3600

tttaaatgtt gagttttttt gggttttgtt ttttttttaa gaaaacatct gaaagccttc   3660

caatgctgta ttaaaccatg agagaaagca gatgtatttt tacatttttt tcttttacag   3720

aactatttca aatttccaat ttttatacta ttagaattaa aaaccagctg actgggtgca   3780

atacgggtga aaatacttgt gacatagaca ttgagatgga ttggggtcag gctgttgccc   3840

tgttttgaat ggtttgggtt taaaatagta ctatttttgt ttgaaaatgt aaagaatttc   3900

ctagaaaaaa attcatgaaa tcaaaaagta gactatttca ccctattgca gctaagtggt   3960

cctggggcat ggagtcttca acctctctat gaatggcaca ccttagtcac ttatgttact   4020

tttgtgtccc caccatgggt tgggggattt tttgtttatt ctgatctatg agttttgaaa   4080

aagtgaataa tcaaaaggaa aataattcct tgttgttcat aaattaagca tcactaaagt   4140

ctcttgaaag gcatttctgt attgggcaag atttaaaata ctaaagcctt aggtcctatt   4200

catatttaaa gtagcatgtt tgtaacctgt tactatttgg agagagaagc agttgcctgc   4260

caaattgaag actacctttc aaatagcaaa agagagagag aaggctgata tttcggcttt   4320

taaataaaga tttgtgtggt tctgctttta ctgtaactgt cactttccca gtgaaaatga   4380

tttcatatac attgagggtc ttacaggtat gggtaaagtt ctataaattg caacaaaatg   4440

atacccaatt tcattttatc ctttttgtat tgtgaaactg gaaactttat gacattgtaa   4500

attatcagct ggtttttctg aatataaagt gtgaaaacac agaacagtat tttgatctat   4560

ttgataattt tgtgggtttt ttgaagaatt aatgagcatg tacatagaaa tagtgactgc   4620

ttgaatactg tatttacttg cactctttca gtacatcaag attcctgtat attttagagt   4680

ataataaaac acagatgtga gttgtattta atgaataatg tatttgtatc tgtgcatatt   4740

atctacaaat ctataaagtt tctagggcat tgactactag attttaagca ttttttctaa   4800

aatatttaca gaaattataa atctaatccc ccatcttttc tttataatat aaagaagtca   4860

taatgaaccc ttcctaatta ttagtagtag gaaggtgaat atgcatttta atgacagtgg   4920

actacatttt ctattgtacc ttttgaaaaa aaaaaaaatc aagcagattc taaaagtata   4980

catatgtgtg ctttctcttt ccttttagga attctcttct gaattccctg agggaatttt   5040

ctagaatctc agaattgaaa gagacctgag gttcatccag tctctaacct cttaacaaat   5100

gcaggagtcc cttctacaag ggtgatcttt ccaccttgaa cacttccaag tgactctacc   5160

tcaccaagca gtccattcag ttgttgagca gctctaactg ttagaaaggt cttccttaga   5220

tggagttgaa gcctccctcc cggtaacttc tgtctttggg cctgggtctg tcctccaaga   5280

gaaccctgag aatgttggaa ggatgaatct cgcacattct gccatgtctt ctcttttaca   5340

ggctgtttga cttctctgct gaagtgattt ccagaaggac tcatttgaca cactattaga   5400

tttaccacat ctaatgaaat ccaaggtgta gctataaagt gacaagctgt ttttaattta   5460

tcacatacac cagaacttct atcctgcatc acttatatgt aaatgatgct gttaccaaaa   5520

acattaaggt agttcttgcg aatgccaccc cactaagaaa actatttcat tacttttgta   5580

atccatctgt gagagtctgc cccccagctt aaccacttcc tttggtctgc acccaatgaa   5640

gggaaacccc aaagtactgt ctcaaatggt atttgaacta cgccagtatt gttggaataa   5700

gtacattaat tacttgaatg aatgaacaca gcaccgtaga aatttccttt atggttacac   5760

cttgtatgtc taaagcattc aggccctgtt ctgtagtgtt tcttatcctc acacagagta   5820

gaaaagcctg tttgctttat ttaacttata cataaaagat gacatctgaa atatctgatg   5880

tgtattataa taccagcttc tgctctagaa ctactttggg tgaaatggtg gtaatagcaa   5940

atgacctcct ttaacaagac actcatctca aacaatgcca tttagttcag gagatctcta   6000

agtgtagctg taaattttgg ggttaatttg gcttatattg gaccttttaa aagaaataaa   6060

gttttttaat gcaat                                                    6075


<210>  9178
<211>  899
<212>  PRT
<213>  Homosapiens

<400>  9178

Met Val Lys Leu Leu Leu Ser Arg Gly Ala Asn Ile Asn Ala Phe Asp 
1               5                   10                  15      


Lys Lys Asp Arg Arg Ala Ile His Trp Ala Ala Tyr Met Gly His Ile 
            20                  25                  30          


Glu Val Val Lys Leu Leu Val Ser His Gly Ala Glu Val Thr Cys Lys 
        35                  40                  45              


Asp Lys Lys Ser Tyr Thr Pro Leu His Ala Ala Ala Ser Ser Gly Met 
    50                  55                  60                  


Ile Ser Val Val Lys Tyr Leu Leu Asp Leu Gly Val Asp Met Asn Glu 
65                  70                  75                  80  


Pro Asn Ala Tyr Gly Asn Thr Pro Leu His Val Ala Cys Tyr Asn Gly 
                85                  90                  95      


Gln Asp Val Val Val Asn Glu Leu Ile Asp Cys Gly Ala Ile Val Asn 
            100                 105                 110         


Gln Lys Asn Glu Lys Gly Phe Thr Pro Leu His Phe Ala Ala Ala Ser 
        115                 120                 125             


Thr His Gly Ala Leu Cys Leu Glu Leu Leu Val Gly Asn Gly Ala Asp 
    130                 135                 140                 


Val Asn Met Lys Ser Lys Asp Gly Lys Thr Pro Leu His Met Thr Ala 
145                 150                 155                 160 


Leu His Gly Arg Phe Ser Arg Ser Gln Thr Ile Ile Gln Ser Gly Ala 
                165                 170                 175     


Val Ile Asp Cys Glu Asp Lys Asn Gly Asn Thr Pro Leu His Ile Ala 
            180                 185                 190         


Ala Arg Tyr Gly His Glu Leu Leu Ile Asn Thr Leu Ile Thr Ser Gly 
        195                 200                 205             


Ala Asp Thr Ala Lys Arg Gly Ile His Gly Met Phe Pro Leu His Leu 
    210                 215                 220                 


Ala Ala Leu Ser Gly Phe Ser Asp Cys Cys Arg Lys Leu Leu Ser Ser 
225                 230                 235                 240 


Gly Phe Asp Ile Asp Thr Pro Asp Asp Phe Gly Arg Thr Cys Leu His 
                245                 250                 255     


Ala Ala Ala Ala Gly Gly Asn Leu Glu Cys Leu Asn Leu Leu Leu Asn 
            260                 265                 270         


Thr Gly Ala Asp Phe Asn Lys Lys Asp Lys Phe Gly Arg Ser Pro Leu 
        275                 280                 285             


His Tyr Ala Ala Ala Asn Cys Asn Tyr Gln Cys Leu Phe Ala Leu Val 
    290                 295                 300                 


Gly Ser Gly Ala Ser Val Asn Asp Leu Asp Glu Arg Gly Cys Thr Pro 
305                 310                 315                 320 


Leu His Tyr Ala Ala Thr Ser Asp Thr Asp Gly Lys Cys Leu Glu Tyr 
                325                 330                 335     


Leu Leu Arg Asn Asp Ala Asn Pro Gly Ile Arg Asp Lys Gln Gly Tyr 
            340                 345                 350         


Asn Ala Val His Tyr Ser Ala Ala Tyr Gly His Arg Leu Cys Leu Gln 
        355                 360                 365             


Leu Ile Ala Ser Glu Thr Pro Leu Asp Val Leu Met Glu Thr Ser Gly 
    370                 375                 380                 


Thr Asp Met Leu Ser Asp Ser Asp Asn Arg Ala Thr Ile Ser Pro Leu 
385                 390                 395                 400 


His Leu Ala Ala Tyr His Gly His His Gln Ala Leu Glu Val Leu Val 
                405                 410                 415     


Gln Ser Leu Leu Asp Leu Asp Val Arg Asn Ser Ser Gly Arg Thr Pro 
            420                 425                 430         


Leu Asp Leu Ala Ala Phe Lys Gly His Val Glu Cys Val Asp Val Leu 
        435                 440                 445             


Ile Asn Gln Gly Ala Ser Ile Leu Val Lys Asp Tyr Ile Leu Lys Arg 
    450                 455                 460                 


Thr Pro Ile His Ala Ala Ala Thr Asn Gly His Ser Glu Cys Leu Arg 
465                 470                 475                 480 


Leu Leu Ile Gly Asn Ala Glu Pro Gln Asn Ala Val Asp Ile Gln Asp 
                485                 490                 495     


Gly Asn Gly Gln Thr Pro Leu Met Leu Ser Val Leu Asn Gly His Thr 
            500                 505                 510         


Asp Cys Val Tyr Ser Leu Leu Asn Lys Gly Ala Asn Val Asp Ala Lys 
        515                 520                 525             


Asp Lys Trp Gly Arg Thr Ala Leu His Arg Gly Ala Val Thr Gly His 
    530                 535                 540                 


Glu Glu Cys Val Asp Ala Leu Leu Gln His Gly Ala Lys Cys Leu Leu 
545                 550                 555                 560 


Arg Asp Ser Arg Gly Arg Thr Pro Ile His Leu Ser Ala Ala Cys Gly 
                565                 570                 575     


His Ile Gly Val Leu Gly Ala Leu Leu Gln Ser Ala Ala Ser Met Asp 
            580                 585                 590         


Ala Asn Pro Ala Thr Ala Asp Asn His Gly Tyr Thr Ala Leu His Trp 
        595                 600                 605             


Ala Cys Tyr Asn Gly His Glu Thr Cys Val Glu Leu Leu Leu Glu Gln 
    610                 615                 620                 


Glu Val Phe Gln Lys Thr Glu Gly Asn Ala Phe Ser Pro Leu His Cys 
625                 630                 635                 640 


Ala Val Ile Asn Asp Asn Glu Gly Ala Ala Glu Met Leu Ile Asp Thr 
                645                 650                 655     


Leu Gly Ala Ser Ile Val Asn Ala Thr Asp Ser Lys Gly Arg Thr Pro 
            660                 665                 670         


Leu His Ala Ala Ala Phe Thr Asp His Val Glu Cys Leu Gln Leu Leu 
        675                 680                 685             


Leu Ser His Asn Ala Gln Val Asn Ser Val Asp Ser Thr Gly Lys Thr 
    690                 695                 700                 


Pro Leu Met Met Ala Ala Glu Asn Gly Gln Thr Asn Thr Val Glu Met 
705                 710                 715                 720 


Leu Val Ser Ser Ala Ser Ala Glu Leu Thr Leu Gln Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Ala Leu His Leu Ala Cys Ser Lys Gly His Glu Thr Ser Ala 
            740                 745                 750         


Leu Leu Ile Leu Glu Lys Ile Thr Asp Arg Asn Leu Ile Asn Ala Thr 
        755                 760                 765             


Asn Ala Ala Leu Gln Thr Pro Leu His Val Ala Ala Arg Asn Gly Leu 
    770                 775                 780                 


Thr Met Val Val Gln Glu Leu Leu Gly Lys Gly Ala Ser Val Leu Ala 
785                 790                 795                 800 


Val Asp Glu Asn Gly Tyr Thr Pro Ala Leu Ala Cys Ala Pro Asn Lys 
                805                 810                 815     


Asp Val Ala Asp Cys Leu Ala Leu Ile Leu Ala Thr Met Met Pro Val 
            820                 825                 830         


Ser Ser Ser Ser Pro Leu Ser Ser Leu Thr Phe Asn Ala Ile Asn Arg 
        835                 840                 845             


Tyr Thr Asn Thr Ser Lys Thr Val Ser Phe Glu Ala Leu Pro Ile Met 
    850                 855                 860                 


Arg Asn Glu Pro Ser Ser Tyr Cys Ser Phe Asn Asn Ile Gly Gly Glu 
865                 870                 875                 880 


Gln Glu Tyr Leu Tyr Thr Asp Val Asp Glu Leu Asn Asp Ser Asp Ser 
                885                 890                 895     


Glu Thr Tyr 
            


<210>  9179
<211>  4753
<212>  DNA
<213>  Homosapiens

<400>  9179
ccgcgggggc tgccagggta tttcgggaag ggggcgtgag gaggcggcgg cggcagcggc     60

gggtagggca ggcagcagag ggaaggagaa agaaaggaag gaagagggcg gggagtcctc    120

agaggaggag gcgggaccgg ccgggcacct cacctctcgg cggcggcggc ggcggcggcg    180

gcggcgggcg gccggggagg cggcgccgcc ccctgcccgc aggtcttctc agcgcagtcg    240

gccgcggacc cgctggtccc gggcagcggc caaggctact ggggcgggag cagtgggccg    300

gtcggcggcg gcagcggcag cggcggagga ggaggaggct ggagtgggcg cggaggcgac    360

cgccatggcg ttcctcaaac tccgtgacca gccatcactg gtgcaagcta tatttaacgg    420

agatcctgat gaagttcgag cactaatatt taagaaagaa gatgttaact ttcaggacaa    480

tgaaaagcga accccattgc acgccgcagc ttaccttgga gatgcagaaa tcattgaact    540

tcttatttta tctggagcta gagttaatgc caaagacagc aaatggttga cacctttaca    600

cagagcagtt gcatcttgta gtgaggaagc agttcaggta cttttgaagc attctgcaga    660

tgttaatgct cgagacaaaa attggcaaac ccctttacat atagctgctg ctaataaagc    720

tgtaaagtgt gctgaagctt tggtacctct tctgagtaat gtaaacgtat ctgatcgagc    780

agggaggact gcattacatc atgcagcttt cagtggacat ggtgagatgg tcaaactact    840

cttgtctaga ggtgccaata ttaatgcttt tgacaagaaa gataggcgtg ctatccattg    900

ggcagcatat atgggtcaca ttgaagtagt gaaattgctt gtgtcgcatg gagctgaagt    960

gacatgcaag gataaaaagt cttatacacc tcttcatgca gcagcctcta gtggaatgat   1020

cagcgtagtc aagtaccttc tagatcttgg agttgatatg aatgaaccaa atgcctatgg   1080

aaatacacct cttcatgtag cctgctataa tggacaagat gttgtagtga atgaacttat   1140

agactgtggt gctattgtga atcaaaagaa tgaaaaagga tttactcctt tgcactttgc   1200

tgctgcatca acacatggag cattgtgttt agagcttcta gttggcaatg gggccgatgt   1260

caatatgaag agtaaagatg ggaaaacccc actacacatg actgctctcc acggtagatt   1320

ctcccgatca caaaccatta tccagagtgg agctgtaatc gactgtgagg ataagaatgg   1380

aaatacccct ttgcacatag cagcacggta tggccatgag ctgctgatca acactcttat   1440

tacaagtggt gctgacactg caaagcgtgg catacatgga atgttccccc tccatttggc   1500

agccttaagc ggcttttcag attgctgcag aaaacttctt tcttcaggat ttgatataga   1560

taccccagat gattttggca ggacttgtct acatgcagct gcagctggag ggaatttgga   1620

gtgcctaaac cttctgctga atactggtgc agactttaat aaaaaggaca aatttgggag   1680

atctccactg cactacgctg ctgccaactg caattaccag tgcctgtttg ctcttgtggg   1740

atcaggagca agtgtgaatg accttgatga aagaggctgc acacccctgc actatgcagc   1800

tacatcagac acagatggca agtgcctgga atacttatta agaaacgatg caaatccagg   1860

gatccgtgat aagcaaggat acaacgcagt tcattattca gctgcttatg gtcaccgtct   1920

atgtcttcag ctgattgcaa gtgaaactcc tctagatgtt ttaatggaaa cctcaggaac   1980

agacatgctg agtgattcag ataatagagc aacaataagc cctttacact tggctgccta   2040

tcatggtcac catcaagcac tggaagtgtt ggtacagtct ttgttagatc ttgatgtcag   2100

aaatagtagt ggaagaacac ccctagatct tgcagctttt aagggccatg ttgaatgtgt   2160

ggatgtactc attaatcagg gagcctcaat cttagtaaaa gattacattt tgaagaggac   2220

acctattcat gcagcagcaa caaatggtca ttcagaatgc ttacggctat taataggaaa   2280

tgcagaacca cagaatgcag tggatattca agatggaaat ggacagacgc ctctgatgct   2340

atctgttctc aacgggcaca cagactgtgt ttactcattg ctgaacaaag gagcaaatgt   2400

agatgccaaa gataagtggg gaaggacagc gttgcataga ggggcagtta caggccatga   2460

agaatgtgta gatgcattac ttcaacatgg tgctaagtgc ttacttcggg atagcagggg   2520

ccggacgcct atacacctgt ctgctgcctg tggacacatt ggtgttcttg gagccctttt   2580

gcagtcagca gcatctatgg atgcaaatcc agccacagca gacaatcatg gatatacggc   2640

acttcactgg gcttgctaca atggtcacga gacatgtgta gaactgcttt tagaacagga   2700

agttttccag aaaacggaag gaaatgcttt tagtccattg cattgtgccg tgataaatga   2760

caacgaaggt gctgctgaga tgttaattga tacattaggt gccagcattg tgaacgccac   2820

agattcaaaa ggaagaactc ctctccatgc agccgccttc acagaccatg tagagtgttt   2880

acagctgctg ctcagccata atgctcaagt caattctgtg gactctacag ggaaaacacc   2940

tcttatgatg gctgcagaaa atggacaaac aaatacagtt gagatgctgg ttagcagtgc   3000

tagtgcagaa ctgactttac aagataacag taaaaatact gccctccatt tggcttgtag   3060

caagggtcat gaaactagtg ccttgttaat actggaaaag ataacagata gaaacctcat   3120

caatgcaacc aacgcagcct tgcaaacacc tctgcatgtt gctgcccgaa atgggctaac   3180

aatggtggtt caggaacttt tgggaaaagg agcaagtgtg cttgcagtag atgaaaatgg   3240

ctatacccca gctttggcct gtgctcccaa taaggatgtg gctgattgcc tggctctcat   3300

tttggccacc atgatgcctg tctcatcaag tagtccttta tcatccttaa cattcaatgc   3360

cattaaccgt tataccaaca cctcaaaaac agtcagcttt gaagctttgc ccatcatgag   3420

gaatgaacct agctcctatt gcagtttcaa taacattgga ggggaacagg agtacttata   3480

cactgacgtg gatgagctca acgactccga ttctgagacc tactgagagg ctgaggagga   3540

gggagttctc acagtaaagc ttcaaactgt gctttttcag gaaaaaggca ctttgatatt   3600

cacgtagaaa ttcaacctaa gaggaaagat cccacagtga gccaatgtta agagatctga   3660

tggcattagg aggaagagtt ttaaaggaat tctcttctga attccctgag ggaattttct   3720

agaatctcag aattgaaaga gacctgaggt tcatccagtc tctaacctct taacaaatgc   3780

aggagtccct tctacaaggg tgatctttcc accttgaaca cttccaagtg actctacctc   3840

accaagcagt ccattcagtt gttgagcagc tctaactgtt agaaaggtct tccttagatg   3900

gagttgaagc ctccctcccg gtaacttctg tctttgggcc tgggtctgtc ctccaagaga   3960

accctgagaa tgttggaagg atgaatctcg cacattctgc catgtcttct cttttacagg   4020

ctgtttgact tctctgctga agtgatttcc agaaggactc atttgacaca ctattagatt   4080

taccacatct aatgaaatcc aaggtgtagc tataaagtga caagctgttt ttaatttatc   4140

acatacacca gaacttctat cctgcatcac ttatatgtaa atgatgctgt taccaaaaac   4200

attaaggtag ttcttgcgaa tgccacccca ctaagaaaac tatttcatta cttttgtaat   4260

ccatctgtga gagtctgccc cccagcttaa ccacttcctt tggtctgcac ccaatgaagg   4320

gaaaccccaa agtactgtct caaatggtat ttgaactacg ccagtattgt tggaataagt   4380

acattaatta cttgaatgaa tgaacacagc accgtagaaa tttcctttat ggttacacct   4440

tgtatgtcta aagcattcag gccctgttct gtagtgtttc ttatcctcac acagagtaga   4500

aaagcctgtt tgctttattt aacttataca taaaagatga catctgaaat atctgatgtg   4560

tattataata ccagcttctg ctctagaact actttgggtg aaatggtggt aatagcaaat   4620

gacctccttt aacaagacac tcatctcaaa caatgccatt tagttcagga gatctctaag   4680

tgtagctgta aattttgggg ttaatttggc ttatattgga ccttttaaaa gaaataaagt   4740

tttttaatgc aat                                                      4753


<210>  9180
<211>  1053
<212>  PRT
<213>  Homosapiens

<400>  9180

Met Ala Phe Leu Lys Leu Arg Asp Gln Pro Ser Leu Val Gln Ala Ile 
1               5                   10                  15      


Phe Asn Gly Asp Pro Asp Glu Val Arg Ala Leu Ile Phe Lys Lys Glu 
            20                  25                  30          


Asp Val Asn Phe Gln Asp Asn Glu Lys Arg Thr Pro Leu His Ala Ala 
        35                  40                  45              


Ala Tyr Leu Gly Asp Ala Glu Ile Ile Glu Leu Leu Ile Leu Ser Gly 
    50                  55                  60                  


Ala Arg Val Asn Ala Lys Asp Ser Lys Trp Leu Thr Pro Leu His Arg 
65                  70                  75                  80  


Ala Val Ala Ser Cys Ser Glu Glu Ala Val Gln Val Leu Leu Lys His 
                85                  90                  95      


Ser Ala Asp Val Asn Ala Arg Asp Lys Asn Trp Gln Thr Pro Leu His 
            100                 105                 110         


Ile Ala Ala Ala Asn Lys Ala Val Lys Cys Ala Glu Ala Leu Val Pro 
        115                 120                 125             


Leu Leu Ser Asn Val Asn Val Ser Asp Arg Ala Gly Arg Thr Ala Leu 
    130                 135                 140                 


His His Ala Ala Phe Ser Gly His Gly Glu Met Val Lys Leu Leu Leu 
145                 150                 155                 160 


Ser Arg Gly Ala Asn Ile Asn Ala Phe Asp Lys Lys Asp Arg Arg Ala 
                165                 170                 175     


Ile His Trp Ala Ala Tyr Met Gly His Ile Glu Val Val Lys Leu Leu 
            180                 185                 190         


Val Ser His Gly Ala Glu Val Thr Cys Lys Asp Lys Lys Ser Tyr Thr 
        195                 200                 205             


Pro Leu His Ala Ala Ala Ser Ser Gly Met Ile Ser Val Val Lys Tyr 
    210                 215                 220                 


Leu Leu Asp Leu Gly Val Asp Met Asn Glu Pro Asn Ala Tyr Gly Asn 
225                 230                 235                 240 


Thr Pro Leu His Val Ala Cys Tyr Asn Gly Gln Asp Val Val Val Asn 
                245                 250                 255     


Glu Leu Ile Asp Cys Gly Ala Ile Val Asn Gln Lys Asn Glu Lys Gly 
            260                 265                 270         


Phe Thr Pro Leu His Phe Ala Ala Ala Ser Thr His Gly Ala Leu Cys 
        275                 280                 285             


Leu Glu Leu Leu Val Gly Asn Gly Ala Asp Val Asn Met Lys Ser Lys 
    290                 295                 300                 


Asp Gly Lys Thr Pro Leu His Met Thr Ala Leu His Gly Arg Phe Ser 
305                 310                 315                 320 


Arg Ser Gln Thr Ile Ile Gln Ser Gly Ala Val Ile Asp Cys Glu Asp 
                325                 330                 335     


Lys Asn Gly Asn Thr Pro Leu His Ile Ala Ala Arg Tyr Gly His Glu 
            340                 345                 350         


Leu Leu Ile Asn Thr Leu Ile Thr Ser Gly Ala Asp Thr Ala Lys Arg 
        355                 360                 365             


Gly Ile His Gly Met Phe Pro Leu His Leu Ala Ala Leu Ser Gly Phe 
    370                 375                 380                 


Ser Asp Cys Cys Arg Lys Leu Leu Ser Ser Gly Phe Asp Ile Asp Thr 
385                 390                 395                 400 


Pro Asp Asp Phe Gly Arg Thr Cys Leu His Ala Ala Ala Ala Gly Gly 
                405                 410                 415     


Asn Leu Glu Cys Leu Asn Leu Leu Leu Asn Thr Gly Ala Asp Phe Asn 
            420                 425                 430         


Lys Lys Asp Lys Phe Gly Arg Ser Pro Leu His Tyr Ala Ala Ala Asn 
        435                 440                 445             


Cys Asn Tyr Gln Cys Leu Phe Ala Leu Val Gly Ser Gly Ala Ser Val 
    450                 455                 460                 


Asn Asp Leu Asp Glu Arg Gly Cys Thr Pro Leu His Tyr Ala Ala Thr 
465                 470                 475                 480 


Ser Asp Thr Asp Gly Lys Cys Leu Glu Tyr Leu Leu Arg Asn Asp Ala 
                485                 490                 495     


Asn Pro Gly Ile Arg Asp Lys Gln Gly Tyr Asn Ala Val His Tyr Ser 
            500                 505                 510         


Ala Ala Tyr Gly His Arg Leu Cys Leu Gln Leu Ile Ala Ser Glu Thr 
        515                 520                 525             


Pro Leu Asp Val Leu Met Glu Thr Ser Gly Thr Asp Met Leu Ser Asp 
    530                 535                 540                 


Ser Asp Asn Arg Ala Thr Ile Ser Pro Leu His Leu Ala Ala Tyr His 
545                 550                 555                 560 


Gly His His Gln Ala Leu Glu Val Leu Val Gln Ser Leu Leu Asp Leu 
                565                 570                 575     


Asp Val Arg Asn Ser Ser Gly Arg Thr Pro Leu Asp Leu Ala Ala Phe 
            580                 585                 590         


Lys Gly His Val Glu Cys Val Asp Val Leu Ile Asn Gln Gly Ala Ser 
        595                 600                 605             


Ile Leu Val Lys Asp Tyr Ile Leu Lys Arg Thr Pro Ile His Ala Ala 
    610                 615                 620                 


Ala Thr Asn Gly His Ser Glu Cys Leu Arg Leu Leu Ile Gly Asn Ala 
625                 630                 635                 640 


Glu Pro Gln Asn Ala Val Asp Ile Gln Asp Gly Asn Gly Gln Thr Pro 
                645                 650                 655     


Leu Met Leu Ser Val Leu Asn Gly His Thr Asp Cys Val Tyr Ser Leu 
            660                 665                 670         


Leu Asn Lys Gly Ala Asn Val Asp Ala Lys Asp Lys Trp Gly Arg Thr 
        675                 680                 685             


Ala Leu His Arg Gly Ala Val Thr Gly His Glu Glu Cys Val Asp Ala 
    690                 695                 700                 


Leu Leu Gln His Gly Ala Lys Cys Leu Leu Arg Asp Ser Arg Gly Arg 
705                 710                 715                 720 


Thr Pro Ile His Leu Ser Ala Ala Cys Gly His Ile Gly Val Leu Gly 
                725                 730                 735     


Ala Leu Leu Gln Ser Ala Ala Ser Met Asp Ala Asn Pro Ala Thr Ala 
            740                 745                 750         


Asp Asn His Gly Tyr Thr Ala Leu His Trp Ala Cys Tyr Asn Gly His 
        755                 760                 765             


Glu Thr Cys Val Glu Leu Leu Leu Glu Gln Glu Val Phe Gln Lys Thr 
    770                 775                 780                 


Glu Gly Asn Ala Phe Ser Pro Leu His Cys Ala Val Ile Asn Asp Asn 
785                 790                 795                 800 


Glu Gly Ala Ala Glu Met Leu Ile Asp Thr Leu Gly Ala Ser Ile Val 
                805                 810                 815     


Asn Ala Thr Asp Ser Lys Gly Arg Thr Pro Leu His Ala Ala Ala Phe 
            820                 825                 830         


Thr Asp His Val Glu Cys Leu Gln Leu Leu Leu Ser His Asn Ala Gln 
        835                 840                 845             


Val Asn Ser Val Asp Ser Thr Gly Lys Thr Pro Leu Met Met Ala Ala 
    850                 855                 860                 


Glu Asn Gly Gln Thr Asn Thr Val Glu Met Leu Val Ser Ser Ala Ser 
865                 870                 875                 880 


Ala Glu Leu Thr Leu Gln Asp Asn Ser Lys Asn Thr Ala Leu His Leu 
                885                 890                 895     


Ala Cys Ser Lys Gly His Glu Thr Ser Ala Leu Leu Ile Leu Glu Lys 
            900                 905                 910         


Ile Thr Asp Arg Asn Leu Ile Asn Ala Thr Asn Ala Ala Leu Gln Thr 
        915                 920                 925             


Pro Leu His Val Ala Ala Arg Asn Gly Leu Thr Met Val Val Gln Glu 
    930                 935                 940                 


Leu Leu Gly Lys Gly Ala Ser Val Leu Ala Val Asp Glu Asn Gly Tyr 
945                 950                 955                 960 


Thr Pro Ala Leu Ala Cys Ala Pro Asn Lys Asp Val Ala Asp Cys Leu 
                965                 970                 975     


Ala Leu Ile Leu Ala Thr Met Met Pro Val Ser Ser Ser Ser Pro Leu 
            980                 985                 990         


Ser Ser Leu Thr Phe Asn Ala Ile  Asn Arg Tyr Thr Asn  Thr Ser Lys 
        995                 1000                 1005             


Thr Val  Ser Phe Glu Ala Leu  Pro Ile Met Arg Asn  Glu Pro Ser 
    1010                 1015                 1020             


Ser Tyr  Cys Ser Phe Asn Asn  Ile Gly Gly Glu Gln  Glu Tyr Leu 
    1025                 1030                 1035             


Tyr Thr  Asp Val Asp Glu Leu  Asn Asp Ser Asp Ser  Glu Thr Tyr 
    1040                 1045                 1050             


<210>  9181
<211>  3001
<212>  DNA
<213>  Homosapiens

<400>  9181
gtgacctata attataaaaa tgataaatgg atttttttaa acatgtgact attggaatag     60

gtttcattag tcatagaagc aattttaata gttttacaac tgtcaaaact catttctaaa    120

atgatcacaa ctaaaagcca tattatttaa aatgcttttg aactgaaatt ttattataac    180

attgacaata atgtattttt ttccttaatc cacctaccta attttctgaa ggaaagtagt    240

actattttgt gtattctgtg gaaatcaact gtaataatat gttacttgaa actaacaata    300

aatgaggtaa gaagctttat gtgtgtctgt aagccaataa ggtttcttaa agaatcaaaa    360

tttttaataa tgtgagcagc caacctccag atagactgac agagatctta catcagtgtc    420

tctcattgtc ccttgctatt ccattttgag gtttagtaaa gataaaaatc ttagaatatt    480

gttgcccgtt ctgggattag tcagatccct tgaaggtcca aaaattagtc atgatgcttg    540

taagctgttt tcaaagccta ttagaattta tgctactgca gtttacagtt tttaatgtat    600

agtctgtatc tttaccagcc tcattcctta acaacggagg aatgcaattt caatggtaaa    660

atgtttttaa acattgaaaa gaaaagtaac aaaaggattg ggtgaaggta gggacctgtc    720

gatgggacct atggctgagc ttgatgccga gctacacgtt gacaaggtgt gacagtgcac    780

tgcacagagg ttctgctctc cctgccccca tctttgttat taggactagg tttctcgagt    840

ttgtacctct tggtcttcac aagttgacaa aaatgctctt tgacagccag gtgtgtatgt    900

gtatgtgcat gcacatgcac atatgtgtac atgtatcatg ttttttcccc tagacctctg    960

catgttgctg cccgaaatgg gctaacaatg gtggttcagg aacttttggg aaaaggagca   1020

agtgtgcttg cagtagatga aaatggctat accccagctt tggcctgtgc tcccaataag   1080

gatgtggctg attgcctggc tctcattttg gccaccatga tgcctgtctc atcaagtagt   1140

cctttatcat ccttaacatt caatgccatt aaccgttata ccaacacctc aaaaacagtc   1200

agctttgaag ctttgcccat catgaggaat gaacctagct cctattgcag tttcaataac   1260

attggagggg aacaggagta cttatacact gacgtggatg agctcaacga ctccgattct   1320

gagacctact gagaggctga ggaggaggga gttctcacag taaagcttca aactgtgctt   1380

tttcaggaaa aaggcacttt gatattcacg tagaaattca acctaagagg aaagatccca   1440

cagtgagcca atgttaagag atctgatggc attaggagga agagttttaa aggcaagttt   1500

tacaaaagga acttctagaa tcttgaaata gacctgactg aggaaaacac attgatgtca   1560

gaattctttg tggaattgtt taatttggtt ttgcagtgcc aggaacaatt ggggacactg   1620

tgcactctaa cctgcttaca caagcaacac tattgtaaca gaagaaataa agacactaga   1680

tttaaatttt atcaataaaa ttacaactaa atttaaaggc aataaaagtt tggtacagta   1740

ggcattatgt gcacagcaaa ttgcaaaagg accaaataac tgaaaggttt ttttaataaa   1800

atgccatttt gtggaaactg gagtagatta aatgaaacat tacctaaacc aaactgcaat   1860

atttctggaa atgaagctga gatttggttt taaatgttga gtttttttgg gttttgtttt   1920

ttttttaaga aaacatctga aagccttcca atgctgtatt aaaccatgag agaaagcaga   1980

tgtattttta catttttttc ttttacagaa ctatttcaaa tttccaattt ttatactatt   2040

agaattaaaa accagctgac tgggtgcaat acgggtgaaa atacttgtga catagacatt   2100

gagatggatt ggggtcaggc tgttgccctg ttttgaatgg tttgggttta aaatagtact   2160

atttttgttt gaaaatgtaa agaatttcct agaaaaaaat tcatgaaatc aaaaagtaga   2220

ctatttcacc ctattgcagc taagtggtcc tggggcatgg agtcttcaac ctctctatga   2280

atggcacacc ttagtcactt atgttacttt tgtgtcccca ccatgggttg ggggattttt   2340

tgtttattct gatctatgag ttttgaaaaa gtgaataatc aaaaggaaaa taattccttg   2400

ttgttcataa attaagcatc actaaagtct cttgaaaggc atttctgtat tgggcaagat   2460

ttaaaatact aaagccttag gtcctattca tatttaaagt agcatgtttg taacctgtta   2520

ctatttggag agagaagcag ttgcctgcca aattgaagac tacctttcaa atagcaaaag   2580

agagagagaa ggctgatatt tcggctttta aataaagatt tgtgtggttc tgcttttact   2640

gtaactgtca ctttcccagt gaaaatgatt tcatatacat tgagggtctt acaggtatgg   2700

gtaaagttct ataaattgca acaaaatgat acccaatttc attttatcct ttttgtattg   2760

tgaaactgga aactttatga cattgtaaat tatcagctgg tttttctgaa tataaagtgt   2820

gaaaacacag aacagtattt tgatctattt gataattttg tgggtttttt gaagaattaa   2880

tgagcatgta catagaaata gtgactgctt gaatactgta tttacttgca ctctttcagt   2940

acatcaagat tcctgtatat tttagagtat aataaaacac agatgtgagt tgtatttaat   3000

g                                                                   3001


<210>  9182
<211>  133
<212>  PRT
<213>  Homosapiens

<400>  9182

Met Tyr His Val Phe Ser Pro Arg Pro Leu His Val Ala Ala Arg Asn 
1               5                   10                  15      


Gly Leu Thr Met Val Val Gln Glu Leu Leu Gly Lys Gly Ala Ser Val 
            20                  25                  30          


Leu Ala Val Asp Glu Asn Gly Tyr Thr Pro Ala Leu Ala Cys Ala Pro 
        35                  40                  45              


Asn Lys Asp Val Ala Asp Cys Leu Ala Leu Ile Leu Ala Thr Met Met 
    50                  55                  60                  


Pro Val Ser Ser Ser Ser Pro Leu Ser Ser Leu Thr Phe Asn Ala Ile 
65                  70                  75                  80  


Asn Arg Tyr Thr Asn Thr Ser Lys Thr Val Ser Phe Glu Ala Leu Pro 
                85                  90                  95      


Ile Met Arg Asn Glu Pro Ser Ser Tyr Cys Ser Phe Asn Asn Ile Gly 
            100                 105                 110         


Gly Glu Gln Glu Tyr Leu Tyr Thr Asp Val Asp Glu Leu Asn Asp Ser 
        115                 120                 125             


Asp Ser Glu Thr Tyr 
    130             


<210>  9183
<211>  4713
<212>  DNA
<213>  Homosapiens

<400>  9183
gactgtgtct tcacaacgtt agacctctct tcagctgcat tgctggctgc ctagagccct     60

agactaatgt aagagctaga gttaatgcca aagacagcaa atggttgaca cctttacaca    120

gagcagttgc atcttgtagt gaggaagcag ttcaggtact tttgaagcat tctgcagatg    180

ttaatgctcg agacaaaaat tggcaaaccc ctttacatat agctgctgct aataaagctg    240

taaagtgtgc tgaagctttg gtacctcttc tgagtaatgt aaacgtatct gatcgagcag    300

ggaggactgc attacatcat gcagctttca gtggacatgg tgagatggtc aaactactct    360

tgtctagagg tgccaatatt aatgcttttg acaagaaaga taggcgtgct atccattggg    420

cagcatatat gggtcacatt gaagtagtga aattgcttgt gtcgcatgga gctgaagtga    480

catgcaagga taaaaagtct tatacacctc ttcatgcagc agcctctagt ggaatgatca    540

gcgtagtcaa gtaccttcta gatcttggag ttgatatgaa tgaaccaaat gcctatggaa    600

atacacctct tcatgtagcc tgctataatg gacaagatgt tgtagtgaat gaacttatag    660

actgtggtgc tattgtgaat caaaagaatg aaaaaggatt tactcctttg cactttgctg    720

ctgcatcaac acatggagca ttgtgtttag agcttctagt tggcaatggg gccgatgtca    780

atatgaagag taaagatggg aaaaccccac tacacatgac tgctctccac ggtagattct    840

cccgatcaca aaccattatc cagagtggag ctgtaatcga ctgtgaggat aagaatggaa    900

ataccccttt gcacatagca gcacggtatg gccatgagct gctgatcaac actcttatta    960

caagtggtgc tgacactgca aagcgtggca tacatggaat gttccccctc catttggcag   1020

ccttaagcgg cttttcagat tgctgcagaa aacttctttc ttcaggattt gatatagata   1080

ccccagatga ttttggcagg acttgtctac atgcagctgc agctggaggg aatttggagt   1140

gcctaaacct tctgctgaat actggtgcag actttaataa aaaggacaaa tttgggagat   1200

ctccactgca ctacgctgct gccaactgca attaccagtg cctgtttgct cttgtgggat   1260

caggagcaag tgtgaatgac cttgatgaaa gaggctgcac acccctgcac tatgcagcta   1320

catcagacac agatggcaag tgcctggaat acttattaag aaacgatgca aatccaggga   1380

tccgtgataa gcaaggatac aacgcagttc attattcagc tgcttatggt caccgtctat   1440

gtcttcagct gattgcaagt gaaactcctc tagatgtttt aatggaaacc tcaggaacag   1500

acatgctgag tgattcagat aatagagcaa caataagccc tttacacttg gctgcctatc   1560

atggtcacca tcaagcactg gaagtgttgg tacagtcttt gttagatctt gatgtcagaa   1620

atagtagtgg aagaacaccc ctagatcttg cagcttttaa gggccatgtt gaatgtgtgg   1680

atgtactcat taatcaggga gcctcaatct tagtaaaaga ttacattttg aagaggacac   1740

ctattcatgc agcagcaaca aatggtcatt cagaatgctt acggctatta ataggaaatg   1800

cagaaccaca gaatgcagtg gatattcaag atggaaatgg acagacgcct ctgatgctat   1860

ctgttctcaa cgggcacaca gactgtgttt actcattgct gaacaaagga gcaaatgtag   1920

atgccaaaga taagtgggga aggacagcgt tgcatagagg ggcagttaca ggccatgaag   1980

aatgtgtaga tgcattactt caacatggtg ctaagtgctt acttcgggat agcaggggcc   2040

ggacgcctat acacctgtct gctgcctgtg gacacattgg tgttcttgga gcccttttgc   2100

agtcagcagc atctatggat gcaaatccag ccacagcaga caatcatgga tatacggcac   2160

ttcactgggc ttgctacaat ggtcacgaga catgtgtaga actgctttta gaacaggaag   2220

ttttccagaa aacggaagga aatgctttta gtccattgca ttgtgccgtg ataaatgaca   2280

acgaaggtgc tgctgagatg ttaattgata cattaggtgc cagcattgtg aacgccacag   2340

attcaaaagg aagaactcct ctccatgcag ccgccttcac agaccatgta gagtgtttac   2400

agctgctgct cagccataat gctcaagtca attctgtgga ctctacaggg aaaacacctc   2460

ttatgatggc tgcagaaaat ggacaaacaa atacagttga gatgctggtt agcagtgcta   2520

gtgcagaact gactttacaa gataacagta aaaatactgc cctccatttg gcttgtagca   2580

agggtcatga aactagtgcc ttgttaatac tggaaaagat aacagataga aacctcatca   2640

atgcaaccaa cgcagccttg caaacacctc tgcatgttgc tgcccgaaat gggctaacaa   2700

tggtggttca ggaacttttg ggaaaaggag caagtgtgct tgcagtagat gaaaatggct   2760

ataccccagc tttggcctgt gctcccaata aggatgtggc tgattgcctg gctctcattt   2820

tggccaccat gatgcctgtc tcatcaagta gtcctttatc atccttaaca ttcaatgcca   2880

ttaaccgtta taccaacacc tcaaaaacag tcagctttga agctttgccc atcatgagga   2940

atgaacctag ctcctattgc agtttcaata acattggagg ggaacaggag tacttataca   3000

ctgacgtgga tgagctcaac gactccgatt ctgagaccta ctgagaggct gaggaggagg   3060

gagttctcac agtaaagctt caaactgtgc tttttcagga aaaaggcact ttgatattca   3120

cgtagaaatt caacctaaga ggaaagatcc cacagtgagc caatgttaag agatctgatg   3180

gcattaggag gaagagtttt aaaggcaagt tttacaaaag gaacttctag aatcttgaaa   3240

tagacctgac tgaggaaaac acattgatgt cagaattctt tgtggaattg tttaatttgg   3300

ttttgcagtg ccaggaacaa ttggggacac tgtgcactct aacctgctta cacaagcaac   3360

actattgtaa cagaagaaat aaagacacta gatttaaatt ttatcaataa aattacaact   3420

aaatttaaag gcaataaaag tttggtacag taggcattat gtgcacagca aattgcaaaa   3480

ggaccaaata actgaaaggt ttttttaata aaatgccatt ttgtggaaac tggagtagat   3540

taaatgaaac attacctaaa ccaaactgca atatttctgg aaatgaagct gagatttggt   3600

tttaaatgtt gagttttttt gggttttgtt ttttttttaa gaaaacatct gaaagccttc   3660

caatgctgta ttaaaccatg agagaaagca gatgtatttt tacatttttt tcttttacag   3720

aactatttca aatttccaat ttttatacta ttagaattaa aaaccagctg actgggtgca   3780

atacgggtga aaatacttgt gacatagaca ttgagatgga ttggggtcag gctgttgccc   3840

tgttttgaat ggtttgggtt taaaatagta ctatttttgt ttgaaaatgt aaagaatttc   3900

ctagaaaaaa attcatgaaa tcaaaaagta gactatttca ccctattgca gctaagtggt   3960

cctggggcat ggagtcttca acctctctat gaatggcaca ccttagtcac ttatgttact   4020

tttgtgtccc caccatgggt tgggggattt tttgtttatt ctgatctatg agttttgaaa   4080

aagtgaataa tcaaaaggaa aataattcct tgttgttcat aaattaagca tcactaaagt   4140

ctcttgaaag gcatttctgt attgggcaag atttaaaata ctaaagcctt aggtcctatt   4200

catatttaaa gtagcatgtt tgtaacctgt tactatttgg agagagaagc agttgcctgc   4260

caaattgaag actacctttc aaatagcaaa agagagagag aaggctgata tttcggcttt   4320

taaataaaga tttgtgtggt tctgctttta ctgtaactgt cactttccca gtgaaaatga   4380

tttcatatac attgagggtc ttacaggtat gggtaaagtt ctataaattg caacaaaatg   4440

atacccaatt tcattttatc ctttttgtat tgtgaaactg gaaactttat gacattgtaa   4500

attatcagct ggtttttctg aatataaagt gtgaaaacac agaacagtat tttgatctat   4560

ttgataattt tgtgggtttt ttgaagaatt aatgagcatg tacatagaaa tagtgactgc   4620

ttgaatactg tatttacttg cactctttca gtacatcaag attcctgtat attttagagt   4680

ataataaaac acagatgtga gttgtattta atg                                4713


<210>  9184
<211>  899
<212>  PRT
<213>  Homosapiens

<400>  9184

Met Val Lys Leu Leu Leu Ser Arg Gly Ala Asn Ile Asn Ala Phe Asp 
1               5                   10                  15      


Lys Lys Asp Arg Arg Ala Ile His Trp Ala Ala Tyr Met Gly His Ile 
            20                  25                  30          


Glu Val Val Lys Leu Leu Val Ser His Gly Ala Glu Val Thr Cys Lys 
        35                  40                  45              


Asp Lys Lys Ser Tyr Thr Pro Leu His Ala Ala Ala Ser Ser Gly Met 
    50                  55                  60                  


Ile Ser Val Val Lys Tyr Leu Leu Asp Leu Gly Val Asp Met Asn Glu 
65                  70                  75                  80  


Pro Asn Ala Tyr Gly Asn Thr Pro Leu His Val Ala Cys Tyr Asn Gly 
                85                  90                  95      


Gln Asp Val Val Val Asn Glu Leu Ile Asp Cys Gly Ala Ile Val Asn 
            100                 105                 110         


Gln Lys Asn Glu Lys Gly Phe Thr Pro Leu His Phe Ala Ala Ala Ser 
        115                 120                 125             


Thr His Gly Ala Leu Cys Leu Glu Leu Leu Val Gly Asn Gly Ala Asp 
    130                 135                 140                 


Val Asn Met Lys Ser Lys Asp Gly Lys Thr Pro Leu His Met Thr Ala 
145                 150                 155                 160 


Leu His Gly Arg Phe Ser Arg Ser Gln Thr Ile Ile Gln Ser Gly Ala 
                165                 170                 175     


Val Ile Asp Cys Glu Asp Lys Asn Gly Asn Thr Pro Leu His Ile Ala 
            180                 185                 190         


Ala Arg Tyr Gly His Glu Leu Leu Ile Asn Thr Leu Ile Thr Ser Gly 
        195                 200                 205             


Ala Asp Thr Ala Lys Arg Gly Ile His Gly Met Phe Pro Leu His Leu 
    210                 215                 220                 


Ala Ala Leu Ser Gly Phe Ser Asp Cys Cys Arg Lys Leu Leu Ser Ser 
225                 230                 235                 240 


Gly Phe Asp Ile Asp Thr Pro Asp Asp Phe Gly Arg Thr Cys Leu His 
                245                 250                 255     


Ala Ala Ala Ala Gly Gly Asn Leu Glu Cys Leu Asn Leu Leu Leu Asn 
            260                 265                 270         


Thr Gly Ala Asp Phe Asn Lys Lys Asp Lys Phe Gly Arg Ser Pro Leu 
        275                 280                 285             


His Tyr Ala Ala Ala Asn Cys Asn Tyr Gln Cys Leu Phe Ala Leu Val 
    290                 295                 300                 


Gly Ser Gly Ala Ser Val Asn Asp Leu Asp Glu Arg Gly Cys Thr Pro 
305                 310                 315                 320 


Leu His Tyr Ala Ala Thr Ser Asp Thr Asp Gly Lys Cys Leu Glu Tyr 
                325                 330                 335     


Leu Leu Arg Asn Asp Ala Asn Pro Gly Ile Arg Asp Lys Gln Gly Tyr 
            340                 345                 350         


Asn Ala Val His Tyr Ser Ala Ala Tyr Gly His Arg Leu Cys Leu Gln 
        355                 360                 365             


Leu Ile Ala Ser Glu Thr Pro Leu Asp Val Leu Met Glu Thr Ser Gly 
    370                 375                 380                 


Thr Asp Met Leu Ser Asp Ser Asp Asn Arg Ala Thr Ile Ser Pro Leu 
385                 390                 395                 400 


His Leu Ala Ala Tyr His Gly His His Gln Ala Leu Glu Val Leu Val 
                405                 410                 415     


Gln Ser Leu Leu Asp Leu Asp Val Arg Asn Ser Ser Gly Arg Thr Pro 
            420                 425                 430         


Leu Asp Leu Ala Ala Phe Lys Gly His Val Glu Cys Val Asp Val Leu 
        435                 440                 445             


Ile Asn Gln Gly Ala Ser Ile Leu Val Lys Asp Tyr Ile Leu Lys Arg 
    450                 455                 460                 


Thr Pro Ile His Ala Ala Ala Thr Asn Gly His Ser Glu Cys Leu Arg 
465                 470                 475                 480 


Leu Leu Ile Gly Asn Ala Glu Pro Gln Asn Ala Val Asp Ile Gln Asp 
                485                 490                 495     


Gly Asn Gly Gln Thr Pro Leu Met Leu Ser Val Leu Asn Gly His Thr 
            500                 505                 510         


Asp Cys Val Tyr Ser Leu Leu Asn Lys Gly Ala Asn Val Asp Ala Lys 
        515                 520                 525             


Asp Lys Trp Gly Arg Thr Ala Leu His Arg Gly Ala Val Thr Gly His 
    530                 535                 540                 


Glu Glu Cys Val Asp Ala Leu Leu Gln His Gly Ala Lys Cys Leu Leu 
545                 550                 555                 560 


Arg Asp Ser Arg Gly Arg Thr Pro Ile His Leu Ser Ala Ala Cys Gly 
                565                 570                 575     


His Ile Gly Val Leu Gly Ala Leu Leu Gln Ser Ala Ala Ser Met Asp 
            580                 585                 590         


Ala Asn Pro Ala Thr Ala Asp Asn His Gly Tyr Thr Ala Leu His Trp 
        595                 600                 605             


Ala Cys Tyr Asn Gly His Glu Thr Cys Val Glu Leu Leu Leu Glu Gln 
    610                 615                 620                 


Glu Val Phe Gln Lys Thr Glu Gly Asn Ala Phe Ser Pro Leu His Cys 
625                 630                 635                 640 


Ala Val Ile Asn Asp Asn Glu Gly Ala Ala Glu Met Leu Ile Asp Thr 
                645                 650                 655     


Leu Gly Ala Ser Ile Val Asn Ala Thr Asp Ser Lys Gly Arg Thr Pro 
            660                 665                 670         


Leu His Ala Ala Ala Phe Thr Asp His Val Glu Cys Leu Gln Leu Leu 
        675                 680                 685             


Leu Ser His Asn Ala Gln Val Asn Ser Val Asp Ser Thr Gly Lys Thr 
    690                 695                 700                 


Pro Leu Met Met Ala Ala Glu Asn Gly Gln Thr Asn Thr Val Glu Met 
705                 710                 715                 720 


Leu Val Ser Ser Ala Ser Ala Glu Leu Thr Leu Gln Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Ala Leu His Leu Ala Cys Ser Lys Gly His Glu Thr Ser Ala 
            740                 745                 750         


Leu Leu Ile Leu Glu Lys Ile Thr Asp Arg Asn Leu Ile Asn Ala Thr 
        755                 760                 765             


Asn Ala Ala Leu Gln Thr Pro Leu His Val Ala Ala Arg Asn Gly Leu 
    770                 775                 780                 


Thr Met Val Val Gln Glu Leu Leu Gly Lys Gly Ala Ser Val Leu Ala 
785                 790                 795                 800 


Val Asp Glu Asn Gly Tyr Thr Pro Ala Leu Ala Cys Ala Pro Asn Lys 
                805                 810                 815     


Asp Val Ala Asp Cys Leu Ala Leu Ile Leu Ala Thr Met Met Pro Val 
            820                 825                 830         


Ser Ser Ser Ser Pro Leu Ser Ser Leu Thr Phe Asn Ala Ile Asn Arg 
        835                 840                 845             


Tyr Thr Asn Thr Ser Lys Thr Val Ser Phe Glu Ala Leu Pro Ile Met 
    850                 855                 860                 


Arg Asn Glu Pro Ser Ser Tyr Cys Ser Phe Asn Asn Ile Gly Gly Glu 
865                 870                 875                 880 


Gln Glu Tyr Leu Tyr Thr Asp Val Asp Glu Leu Asn Asp Ser Asp Ser 
                885                 890                 895     


Glu Thr Tyr 
            


<210>  9185
<211>  646
<212>  DNA
<213>  Homosapiens

<400>  9185
gaaaataaaa cctttttggg gggtagggcc cagacgggat ctcactctgt cacccaggct     60

ggaatgcagt ggtgcaatca tagctcactg ttgcctcaaa ctcctgggct caagtgatcc    120

tcctgcctca gcctcctgaa cagctgggat cacaggcatg catcatcatg cacttttttt    180

ttttttggta gagatgcagg tcttgctatg ttgaccaggc tggtcttaaa ctcctggctt    240

caagtcatcc tcccacttca gcctcccaga ttgttaggat tataggcatg agccactgtg    300

cctggctaaa actatttaat acatagttga attcctacct tccttttgaa tctgtggcgt    360

tcacaatgct ggcacctaat gtatcaatta acatctcagc agcaccttcg ttgtcattta    420

tcctgtgtaa ggtaacaagg tgatcattct cacagcaatg gtgtatttct taaaacactc    480

aaaccaaatc tgattcattc tggctttact tacacggcac aatgcaatgg actaaaagca    540

tttccttccg ttttctggaa aattacaact taattcaatg taaatgctat ataaatagtt    600

gttgtattgt ttagggaata atgacaaaaa aaaagtctgt acatgt                   646


<210>  9186
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  9186

Met Gln Trp Thr Lys Ser Ile Ser Phe Arg Phe Leu Glu Asn Tyr Asn 
1               5                   10                  15      


Leu Ile Gln Cys Lys Cys Tyr Ile Asn Ser Cys Cys Ile Val 
            20                  25                  30  


<210>  9187
<211>  4928
<212>  DNA
<213>  Homosapiens

<400>  9187
ccatttctgc ctggtgcctg tgcccttttg ctggagcagc cacagacaac tgcctgatgg     60

agaaagaatg aacgctctgc cttgcttatg ctatcgatgg gaataaagct aactgtgttt    120

cttctattat atgggaaacc tggattaatc aagctgtatt ctagtaccaa gagtcgtatt    180

gtctcttgtg gtctgactca tcacatgtaa acgtactgca gctttgctat taatgcagag    240

tggttttttt ttttttgttt ttgttttttg cccctttccc aaacactgaa agaattgtta    300

acctctgagc ttcattttca ggatttgtgc tgagctctag atcttttttc tgtgaatagt    360

atctgcatta aaccagtgat gaagaaatga agacaaatta gaagtggaaa cagaatagtg    420

agattttatt ttttattttc aattataagc aaaacagcta ctggtaacta tatgaccttg    480

caggcaagag tgggtatcgc tgtgatcatc tctgtcacag cagttgtttc tcatttcatt    540

ctatattgtg tggtgttgtg tcaccaaaaa caatgattgt tttgtgcaag taaatttcag    600

agatagagca ataagactat tttggtagag gaaaaatatt tttaaatgag cttggactca    660

gttttagtta ttgacatgtt ggtgtgaaat ttcttcttaa gtattgcagt aatccaacag    720

aaataataga atttcgttat atttaggaag ttacaaatta tgtagtcata attttaaact    780

tgtttttcca gtagtactta ttaactttaa aaaaaaaaaa aacccagctg tgctgttcag    840

agaatgtttg taagtgttgt acagaagagg aggaaaaact acttgtgctc ttccaactgt    900

gacttttatc acatagcttg gaatttagtg ttttaaaaga tcgaatgagt cgagtgtgta    960

ttgttgtttt ggaggaggta gaagatgaat ctcctgcatt catttctaaa ttgccacagg   1020

aaaataaatc cctacattct ccaccttctg gaaatgtatt ggtaagatat ccatcactgg   1080

tgcaagctat atttaacgga gatcctgatg aagttcgagc actaatattt aagaaagaag   1140

atgttaactt tcaggacaat gaaaagcgaa ccccattgca cgccgcagct taccttggag   1200

atgcagaaat cattgaactt cttattttat ctggagctag agttaatgcc aaagacagca   1260

aatggttgac acctttacac agagcagttg catcttgtag tgaggaagca gttcaggtac   1320

ttttgaagca ttctgcagat gttaatgctc gagacaaaaa ttggcaaacc cctttacata   1380

tagctgctgc taataaagct gtaaagtgtg ctgaagcttt ggtacctctt ctgagtaatg   1440

taaacgtatc tgatcgagca gggaggactg cattacatca tgcagctttc agtggacatg   1500

gtgagatggt caaactactc ttgtctagag gtgccaatat taatgctttt gacaagaaag   1560

ataggcgtgc tatccattgg gcagcatata tgggtcacat tgaagtagtg aaattgcttg   1620

tgtcgcatgg agctgaagtg acatgcaagg ataaaaagtc ttatacacct cttcatgcag   1680

cagcctctag tggaatgatc agcgtagtca agtaccttct agatcttgga gttgatatga   1740

atgaaccaaa tgcctatgga aatacacctc ttcatgtagc ctgctataat ggacaagatg   1800

ttgtagtgaa tgaacttata gactgtggtg ctattgtgaa tcaaaagaat gaaaaaggat   1860

ttactccttt gcactttgct gctgcatcaa cacatggagc attgtgttta gagcttctag   1920

ttggcaatgg ggccgatgtc aatatgaaga gtaaagatgg gaaaacccca ctacacatga   1980

ctgctctcca cggtagattc tcccgatcac aaaccattat ccagagtgga gctgtaatcg   2040

actgtgagga taagaatgga aatacccctt tgcacatagc agcacggtat ggccatgagc   2100

tgctgatcaa cactcttatt acaagtggtg ctgacactgc aaagcgtggc atacatggaa   2160

tgttccccct ccatttggca gccttaagcg gcttttcaga ttgctgcaga aaacttcttt   2220

cttcaggatt tgatatagat accccagatg attttggcag gacttgtcta catgcagctg   2280

cagctggagg gaatttggag tgcctaaacc ttctgctgaa tactggtgca gactttaata   2340

aaaaggacaa atttgggaga tctccactgc actacgctgc tgccaactgc aattaccagt   2400

gcctgtttgc tcttgtggga tcaggagcaa gtgtgaatga ccttgatgaa agaggctgca   2460

cacccctgca ctatgcagct acatcagaca cagatggcaa gtgcctggaa tacttattaa   2520

gaaacgatgc aaatccaggg atccgtgata agcaaggata caacgcagtt cattattcag   2580

ctgcttatgg tcaccgtcta tgtcttcagc tgattgcaag tgaaactcct ctagatgttt   2640

taatggaaac ctcaggaaca gacatgctga gtgattcaga taatagagca acaataagcc   2700

ctttacactt ggctgcctat catggtcacc atcaagcact ggaagtgttg gtacagtctt   2760

tgttagatct tgatgtcaga aatagtagtg gaagaacacc cctagatctt gcagctttta   2820

agggccatgt tgaatgtgtg gatgtactca ttaatcaggg agcctcaatc ttagtaaaag   2880

attacatttt gaagaggaca cctattcatg cagcagcaac aaatggtcat tcagaatgct   2940

tacggctatt aataggaaat gcagaaccac agaatgcagt ggatattcaa gatggaaatg   3000

gacagtaagt ttcgataaat aattgttgca tcacagaagg gcgtatttcg aaaaccagag   3060

tacagtctta agtgacagca ctgaacctat tcctgttgtt gctcaggacg cctctgatgc   3120

tatctgttct caacgggcac acagactgtg tttactcatt gctgaacaaa ggagcaaatg   3180

tagatgccaa agataagtgg ggaaggacag cgttgcatag aggggcagtt acaggccatg   3240

aagaatgtgt agatgcatta cttcaacatg gtgctaagtg cttacttcgg gatagcaggg   3300

gccggacgcc tatacacctg tctgctgcct gtggacacat tggtgttctt ggagcccttt   3360

tgcagtcagc agcatctatg gatgcaaatc cagccacagc agacaatcat ggatatacgg   3420

cacttcactg ggcttgctac aatggttaag tatacaaaca caaatgcata tcattgtgta   3480

gtgaacagag ataaaagaat gacatattta taaggcaaat tttaagttta aaattagcaa   3540

aaaccttggg aataatctac tgtataggct cacgtactaa taatacttag tacgtaggct   3600

cactcctgtc ctttgtcatg ctaaagccaa gacactagtt gtcaaaggtg ttctgagata   3660

agccatgaag tatttttgag gtttttcttt tcttttcttt tcttttttag ttttggtagg   3720

atcttgctat gttgcccagg ctggtcttga actcctggca tcaagtgatc ctcccacctc   3780

agcctcccaa agtgttggga ttacaggcat gagccaccat gtagcctgaa gtttttctta   3840

gatccttatt tccacaaata ttttgcattt ttaggaggtt tttagaatgt ttccattgct   3900

tttatatagt gtgcttgtat tttgattgtg ttcttttact attttttttt ttttaagagt   3960

cccactatgt tgcccaggct ggtcttgaac aactgggctt aagcaatcct cccacatcag   4020

actccccaag tgctaggatt acaggcatga gccattgcac ccagccatgt tcttttactt   4080

tctaaataca atcatattag gggaaaaata accaaaagta ggagaaacag tgagatgtat   4140

cacattctaa actgaaatct atgtatgttt tctgagcaca ttgcaagata acattcttat   4200

attaccagta atatccatgt tcaatgtttt aaaggaataa atccctagca ggtcttagaa   4260

ttagaaactt tgatgggtta actctgctac atggttaaaa gagattttct ttggcctcct   4320

acaggctcac agtcacagtc atcgctttta taggtagact cataaaaggt cacgtaggga   4380

agcataaagc tactttgaag ttatagatgt taaaaatgca gtttggctta tgaaatgcca   4440

ctaattaaaa taatttatgc aatgaagcat gttgagatat ttttagattt gatcatctta   4500

gaaaactcaa gtacattata tacagtgcaa gcatcagtgt tgtcaaagtt caagcttcag   4560

gctttagtag agaaattaga ggtttttaaa atttgttttc aatttcagtg tagcttcaag   4620

attaatgtta attatgacag cagatctaca aagctgtagt tcacaattct aataaccttc   4680

cctcaaaatg cagagaaaat ataagttgtc tctttatata aatacccatt tgctaaaaat   4740

aaataagtat aatatctgtt gtaaaatcag actgccttac caggaagttg agatttccta   4800

tctttctata atatgctgtt tcatagttct ttcactggga gctgttctga caaagttatc   4860

aagttaaagc aaaagaggaa aaagctgaat cttgtaaaat tataacttca ttaaatgttt   4920

ccacaagt                                                            4928


<210>  9188
<211>  687
<212>  PRT
<213>  Homosapiens

<400>  9188

Met Ser Arg Val Cys Ile Val Val Leu Glu Glu Val Glu Asp Glu Ser 
1               5                   10                  15      


Pro Ala Phe Ile Ser Lys Leu Pro Gln Glu Asn Lys Ser Leu His Ser 
            20                  25                  30          


Pro Pro Ser Gly Asn Val Leu Val Arg Tyr Pro Ser Leu Val Gln Ala 
        35                  40                  45              


Ile Phe Asn Gly Asp Pro Asp Glu Val Arg Ala Leu Ile Phe Lys Lys 
    50                  55                  60                  


Glu Asp Val Asn Phe Gln Asp Asn Glu Lys Arg Thr Pro Leu His Ala 
65                  70                  75                  80  


Ala Ala Tyr Leu Gly Asp Ala Glu Ile Ile Glu Leu Leu Ile Leu Ser 
                85                  90                  95      


Gly Ala Arg Val Asn Ala Lys Asp Ser Lys Trp Leu Thr Pro Leu His 
            100                 105                 110         


Arg Ala Val Ala Ser Cys Ser Glu Glu Ala Val Gln Val Leu Leu Lys 
        115                 120                 125             


His Ser Ala Asp Val Asn Ala Arg Asp Lys Asn Trp Gln Thr Pro Leu 
    130                 135                 140                 


His Ile Ala Ala Ala Asn Lys Ala Val Lys Cys Ala Glu Ala Leu Val 
145                 150                 155                 160 


Pro Leu Leu Ser Asn Val Asn Val Ser Asp Arg Ala Gly Arg Thr Ala 
                165                 170                 175     


Leu His His Ala Ala Phe Ser Gly His Gly Glu Met Val Lys Leu Leu 
            180                 185                 190         


Leu Ser Arg Gly Ala Asn Ile Asn Ala Phe Asp Lys Lys Asp Arg Arg 
        195                 200                 205             


Ala Ile His Trp Ala Ala Tyr Met Gly His Ile Glu Val Val Lys Leu 
    210                 215                 220                 


Leu Val Ser His Gly Ala Glu Val Thr Cys Lys Asp Lys Lys Ser Tyr 
225                 230                 235                 240 


Thr Pro Leu His Ala Ala Ala Ser Ser Gly Met Ile Ser Val Val Lys 
                245                 250                 255     


Tyr Leu Leu Asp Leu Gly Val Asp Met Asn Glu Pro Asn Ala Tyr Gly 
            260                 265                 270         


Asn Thr Pro Leu His Val Ala Cys Tyr Asn Gly Gln Asp Val Val Val 
        275                 280                 285             


Asn Glu Leu Ile Asp Cys Gly Ala Ile Val Asn Gln Lys Asn Glu Lys 
    290                 295                 300                 


Gly Phe Thr Pro Leu His Phe Ala Ala Ala Ser Thr His Gly Ala Leu 
305                 310                 315                 320 


Cys Leu Glu Leu Leu Val Gly Asn Gly Ala Asp Val Asn Met Lys Ser 
                325                 330                 335     


Lys Asp Gly Lys Thr Pro Leu His Met Thr Ala Leu His Gly Arg Phe 
            340                 345                 350         


Ser Arg Ser Gln Thr Ile Ile Gln Ser Gly Ala Val Ile Asp Cys Glu 
        355                 360                 365             


Asp Lys Asn Gly Asn Thr Pro Leu His Ile Ala Ala Arg Tyr Gly His 
    370                 375                 380                 


Glu Leu Leu Ile Asn Thr Leu Ile Thr Ser Gly Ala Asp Thr Ala Lys 
385                 390                 395                 400 


Arg Gly Ile His Gly Met Phe Pro Leu His Leu Ala Ala Leu Ser Gly 
                405                 410                 415     


Phe Ser Asp Cys Cys Arg Lys Leu Leu Ser Ser Gly Phe Asp Ile Asp 
            420                 425                 430         


Thr Pro Asp Asp Phe Gly Arg Thr Cys Leu His Ala Ala Ala Ala Gly 
        435                 440                 445             


Gly Asn Leu Glu Cys Leu Asn Leu Leu Leu Asn Thr Gly Ala Asp Phe 
    450                 455                 460                 


Asn Lys Lys Asp Lys Phe Gly Arg Ser Pro Leu His Tyr Ala Ala Ala 
465                 470                 475                 480 


Asn Cys Asn Tyr Gln Cys Leu Phe Ala Leu Val Gly Ser Gly Ala Ser 
                485                 490                 495     


Val Asn Asp Leu Asp Glu Arg Gly Cys Thr Pro Leu His Tyr Ala Ala 
            500                 505                 510         


Thr Ser Asp Thr Asp Gly Lys Cys Leu Glu Tyr Leu Leu Arg Asn Asp 
        515                 520                 525             


Ala Asn Pro Gly Ile Arg Asp Lys Gln Gly Tyr Asn Ala Val His Tyr 
    530                 535                 540                 


Ser Ala Ala Tyr Gly His Arg Leu Cys Leu Gln Leu Ile Ala Ser Glu 
545                 550                 555                 560 


Thr Pro Leu Asp Val Leu Met Glu Thr Ser Gly Thr Asp Met Leu Ser 
                565                 570                 575     


Asp Ser Asp Asn Arg Ala Thr Ile Ser Pro Leu His Leu Ala Ala Tyr 
            580                 585                 590         


His Gly His His Gln Ala Leu Glu Val Leu Val Gln Ser Leu Leu Asp 
        595                 600                 605             


Leu Asp Val Arg Asn Ser Ser Gly Arg Thr Pro Leu Asp Leu Ala Ala 
    610                 615                 620                 


Phe Lys Gly His Val Glu Cys Val Asp Val Leu Ile Asn Gln Gly Ala 
625                 630                 635                 640 


Ser Ile Leu Val Lys Asp Tyr Ile Leu Lys Arg Thr Pro Ile His Ala 
                645                 650                 655     


Ala Ala Thr Asn Gly His Ser Glu Cys Leu Arg Leu Leu Ile Gly Asn 
            660                 665                 670         


Ala Glu Pro Gln Asn Ala Val Asp Ile Gln Asp Gly Asn Gly Gln 
        675                 680                 685         


<210>  9189
<211>  4078
<212>  DNA
<213>  Homosapiens

<400>  9189
ggggacaggg aagactgaaa acggacatga gggaacttgc tgggagaatt gttttcttcc     60

ttgctcctaa atcacagagg agatagtcca taaccagtga gctgggccag aagctaagta    120

cttttatccc tcttcccaaa ctggaaataa tgcttttctt tggctaccta acagtgcagt    180

ggcaaaaggt tcagattcgg ttttcaggct cagagtagaa tgagcaaaaa ccaatgacat    240

ttccactttt ccaactataa tgctgaaaaa aatagctgct gcactgtatc ttttaagagt    300

gttgtggata ccagctattg tgggtttgtt caactcccaa cccctggcaa ctcagaatat    360

gactttaact ggagatagac tctttacaga ggtaattaaa atgaggtcat tagggtgggc    420

cctaatacag tatgactggt gtccttacaa gaagaaattt gcaaaaagac atggacagag    480

ggaaaataaa gggagaagac agcgattttg caagccagag agagataccc tgaacagatc    540

cttccctctc agccttccaa aggaatcaat cctgacggca ccttgatctc agacttacag    600

cctccagaac tttgagtaaa taaatttcta ttgtttaagc cgcccagttt gtagtacttt    660

gttacagcag ccccaccaaa ctaatgtacc agcactgaag taaaaagaag agacacatac    720

tttaggtttc attcttaatg ccagaaacat cagaacggtg ttttctagta aggagagtat    780

tttttataaa aggccaatcg aatgaatttt tgacaaatgc cttccacaat gcagtcattt    840

aaggacttaa tacttactgg aggcagtcta aggtctgagg tactgctaac catatagttt    900

tgaatgcaag cattaagtga ataagctccc aaacaaaata tctatacctc agtggccagc    960

aaatagtctt taaaagttct tcaataaaag tgacttcaca tgtaaatttt actaaaagct   1020

aaataggtgg ttgggggagg agggtggaaa ttatggtggg aagaaaaaag gaagattctg   1080

attacggcag gattaagaac acggattctg tagtcaaact gcctggatct gaattctgcc   1140

tctagctttt actagcagta taaaaacttt gaaagtttaa aagctaaatg tcttagtttc   1200

cttatataat accttcacaa atttaggcta aaatgagatt agtgaaatgg ctaaatttaa   1260

cagtatttaa aatgtaataa gctcactgtt tgctattatt tcaccccatt ccataataat   1320

tattaacatt aattccagtg gactctagta ttactataga ttctatggat gtattcactt   1380

gtttgattac aggtgccacg ccaaaaatta tacctctcat ccacaaatct tagagttgca   1440

tcatgtacaa atacttggtt tctgaagaat tctggactgc aagttaaaga aagtgagtag   1500

ttttactcta aaacaagtca ccaaaatata aaagagaatg agaagagata ccatcttcaa   1560

tacaataagg aaacagttac aaccacaaac caaactatga attatttcta tcaataacag   1620

tgaaatgtgt accaaactga aggacactga gtcaagcgaa gcttcttcag atcttgggaa   1680

ggttaccgag tcctctaaaa agtcatgttt gcatgtgtgt cccatttgct cctttctctc   1740

tgctgtgtcc taaaatccct aaaaatcttt cagacgatct agagctgtct gggtaattca   1800

caggaaaagc acctacagaa ctcttaacct cacactgcat aagaataaag tggggcagtg   1860

ctaaaaaaga gaccaagaag gcatctttat taatttttta cccagctgga gatgagggag   1920

agtaacagcc aatcaccagc agattactat ctaagaactc attgatctaa gaagctgctg   1980

agccagccca actacctgtg gtatatcaac aaaaaaagga aactaaatga tgagaacata   2040

tggacacaca gagggacaca acacacactg gggcctatca gagggtggac gataagagga   2100

gagagaggtt caggaaaaat aatgggaact aggcttaata tatggatgat gaaataatct   2160

gtacaacaaa cccacatgac ttaactttac ctatataaca cacctgcgca tgtactcctg   2220

aacttaaaat ttggttactt aagtttacct atataacaca cctgtgcatg tactcctgaa   2280

cttaaaattt ggtttgagag ttatttgaag aaacaaacct aacagatgtt cactttttgc   2340

cccttccttt ctgttctgca aagaggcata ttcctcgaag atacgtaaga atctgaaagc   2400

atccagcaca ggactaggat aaaaatatac agagtagagt aaactaggag aaatgcagtt   2460

ggaaaaaacc atcccagaaa ataagatgaa ttcatgagct actctatata ctcaacttca   2520

ctgaatttaa gttctgaaga ggagacctca aagaaaagtt acaagaaaga gataagacaa   2580

tgtagagaga ctatgagagc tagctgagtt tggggaaaaa aggaaaacta ttaaagataa   2640

aaacctagaa ataacaaaaa gtaggataaa catgacttaa aatggtcaag aatttgaagc   2700

caaagccaga gaatcaatct ttaaaaacat aagtcagagc atgttattcc actccaaaca   2760

gaactctcca ttggttttcc acatcactta aagggccaag gcaacacaaa agagtgaaac   2820

caattggaga aaatataaat atccttattt cctaattttt aatcacaagt cagacataat   2880

aaaaacctga aatatgaaca cagaaggaaa tgactctaaa ataatctcaa tctttctatt   2940

tttttatgtt agagaaatat atttagagaa tatagaactc ttgctatgga tatcgcagta   3000

gtttttaaaa tacaaaatta cagtaactga ctattgtatg ttcttatgaa aacatatgac   3060

tttaatgcaa tcttacacga cttttataca aataagcatt atttcatatt gcttaattta   3120

cttaagatta tacctacctg ctactaaaat gtggtgttgg taattaacat gaagtgtaaa   3180

cacctacact aaattttcat tactaactat aaacaaatta gcctaatttt gttgcctata   3240

tttctcttca tgtatttttt tctcatcttt acctagagaa ttgatcagat caaatatcta   3300

gtttcaattc taatttataa ctcaacttac cataattcat taaaaggctg ttttgatgga   3360

tccagaattt aaaattaggg ttatagaaat cagtcagttt aacttgggcc tcagcaacca   3420

tggcattcaa accaaattta agcagaactc ctggagcatc tatacagaac cttatgagtc   3480

tatatactat atattgtctg aagactattc ttctgatatt tattctgaac taaaatttgg   3540

atacgattag tcttttacta ccctgctatt ctggaaatct atttccaata taaaagtaag   3600

aattcactgg ttagcttata cttgacttct aaaatgtgta gtatatcttc tgtaaaactg   3660

tcctaatcaa ctttcaattt aaagagttaa taggaattta aaatggatat aacatgaatg   3720

aactgaagaa atatccacca atcaaaattc cttcctgatc aggtttctgg ttcagatttc   3780

aaaatctctc ctgggctggg catggtggct cacagctgta atcccagcac tttgggaggc   3840

cgtggtgggt ggatcacctg gggtcaggag ttcgagacca gcctggccaa catggtgaaa   3900

ccccatctct actaaaaata caaaaattag ttgggcctgg tgatgcatgc ctgtaatccc   3960

agctactcag gaggctgagg caggagaatc atttgaacct ggtaggtgga ggttgcagta   4020

aaccgagaga tggtgccact gccctccagc ctgggtaaca gagcaagact atgtcttt     4078


<210>  9190
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  9190

Met Leu Lys Lys Ile Ala Ala Ala Leu Tyr Leu Leu Arg Val Leu Trp 
1               5                   10                  15      


Ile Pro Ala Ile Val Gly Leu Phe Asn Ser Gln Pro Leu Ala Thr Gln 
            20                  25                  30          


Asn Met Thr Leu Thr Gly Asp Arg Leu Phe Thr Glu Val Ile Lys Met 
        35                  40                  45              


Arg Ser Leu Gly Trp Ala Leu Ile Gln Tyr Asp Trp Cys Pro Tyr Lys 
    50                  55                  60                  


Lys Lys Phe Ala Lys Arg His Gly Gln Arg Glu Asn Lys Gly Arg Arg 
65                  70                  75                  80  


Gln Arg Phe Cys Lys Pro Glu Arg Asp Thr Leu Asn Arg Ser Phe Pro 
                85                  90                  95      


Leu Ser Leu Pro Lys Glu Ser Ile Leu Thr Ala Pro 
            100                 105             


<210>  9191
<211>  684
<212>  DNA
<213>  Homosapiens

<400>  9191
acgtatctct cctgctccag tgttccttcc actaacccat gactgtgtct tcacaacgtt     60

agacctctct tcagctgcat tgctggctgc ctagagccct agactaatgt aagagctaga    120

gttaatgcca aagacagcaa atggttgaca cctttacaca gagcagttgc atcttgtagt    180

gagtctaaaa attacaaggc agatgactaa acagaaacac aaccaagaac cctcagagtc    240

cgcttcactc ccctgctacc tccactggag caggtgctag tatccacagc tgaaggacct    300

gaagacagat cacatcacag gactctttac agacattccc cagtaccatc ccggagccta    360

gtagctccac tgggttacta gacccagaag agcaaaaaca atcactacag tttggctctc    420

aggaataccc attcctaggg gaagtgggag aacaccacat caagggaaca cccagtggga    480

caaaataatt taaacagtag tccttgaatc ccagatcttc cctctgacat agcctaccca    540

aatgagaaag aaccagaaaa acaattctgg taatatgaca aaacaaggtt atttaacacc    600

cccaaaatat accagctcac cagcaatgga tgcaaaccaa gatgaagtct atgaattgcc    660

aggaaaagaa gtcagaagat tgat                                           684


<210>  9192
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  9192

Met Arg Lys Asn Gln Lys Asn Asn Ser Gly Asn Met Thr Lys Gln Gly 
1               5                   10                  15      


Tyr Leu Thr Pro Pro Lys Tyr Thr Ser Ser Pro Ala Met Asp Ala Asn 
            20                  25                  30          


Gln Asp Glu Val Tyr Glu Leu Pro Gly Lys Glu Val Arg Arg 
        35                  40                  45      


<210>  9193
<211>  693
<212>  DNA
<213>  Homosapiens

<400>  9193
caggtgccac gccaaaaatt atacctctca tccacaaatc ttagagttgc atcatgtaca     60

aatacttggt ttctgaagaa ttctggactg caagttaaag aaaatgagga agttgaggct    120

cagagagcaa ataaacttca aaagatcatg gaggtgctaa gagaggttac cataccagat    180

aaaataagaa gttcaatgat ttctgcatct ccaaggaaaa gaagctacct ctaatgcatg    240

cttcatggac ctcctaccag aaaacaacag tgctctccag ttcaagatgc aagattttag    300

agtaatgtca cattcaggga tttttaattc atagataccc tatctaaagt tacaacagag    360

tattactgac ttggctgcat ttgaaaaaaa ctattcagaa atactcacat tgaaacttac    420

atccctcatt tttgataaag gcttttgtga cagatagtta gttgttttcc actatgttct    480

tccttttgtc cacaggaata aaattttagc tggtcactta gccacccagt gagagaatac    540

attcctggcc tcccttgaag ttgttgcttg gtgtggacca atggtatgtg agtggaaatt    600

aataatgggc acaacttcca ggtcatcttc aacttaaaag acaactactc taggctgggc    660

acagtggctc acgcctgtaa tcccagcact ttg                                 693


<210>  9194
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  9194

Ile Pro Tyr Leu Lys Leu Gln Gln Ser Ile Thr Asp Leu Ala Ala Phe 
1               5                   10                  15      


Glu Lys Asn Tyr Ser Glu Ile Leu Thr Leu Lys Leu Thr Ser Leu Ile 
            20                  25                  30          


Phe Asp Lys Gly Phe Cys Asp Arg 
        35                  40  


<210>  9195
<211>  452
<212>  DNA
<213>  Homosapiens

<400>  9195
cacgccaaaa attatacctc tcatccacaa atcttagagt tgcatcatgt acaaatactt     60

ggtttctgaa gaattctgga ctgcaagtta aagaaaaggt taccatacca gataaaataa    120

gaagttcaat gatttctgca tctccaagga aaagaagcta cctctaatgc atgcttcatg    180

gacctcctac cagaaaacaa cagtgctctc cagttcaaga tgcaagattt tagagtaatg    240

tcacattcag ggatttttaa ttcatagata ccctatctaa agttacaaca gagtattact    300

gacttggctg catttgaaaa aaactattca gaaatactca cattgaaact tacatccctc    360

atttttgata aaggcttttg tgacagatag ttagttgttt tccactatgt tcttcctttt    420

gtccacagga ataaaatttt agctggtcac tt                                  452


<210>  9196
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  9196

Ile Pro Tyr Leu Lys Leu Gln Gln Ser Ile Thr Asp Leu Ala Ala Phe 
1               5                   10                  15      


Glu Lys Asn Tyr Ser Glu Ile Leu Thr Leu Lys Leu Thr Ser Leu Ile 
            20                  25                  30          


Phe Asp Lys Gly Phe Cys Asp Arg 
        35                  40  


<210>  9197
<211>  1375
<212>  DNA
<213>  Homosapiens

<400>  9197
ccatttctgc ctggtgcctg tgcccttttg ctggagcagc cacagacaac tgcctgatgg     60

agaaagaatg aacgctctgc cttgcttatg ctatcgatgg gaataaagct aactgtgttt    120

cttctattat atgggaaacc tggattaatc aagctgtatt ctagtaccaa gagtcgtatt    180

gtctcttgtg gtctgactca tcacatgtaa acgtactgca gctttgctat taatgcagag    240

tggttttttt ttttttgttt ttgttttttg cccctttccc aaacactgaa agaattgtta    300

acctctgagc ttcattttca ggatttgtgc tgagctctag atcttttttc tgtgaatagt    360

atctgcatta aaccagtgat gaagaaatga agacaaatta gaagtggaaa cagaatagtg    420

agattttatt ttttattttc aattataagc aaaacagcta ctggtaacta tatgaccttg    480

caggcaagag tgggtatcgc tgtgatcatc tctgtcacag cagttgtttc tcatttcatt    540

ctatattgtg tggtgttgtg tcaccaaaaa caatgattgt tttgtgcaag taaatttcag    600

agatagagca ataagactat tttggtagag gaaaaatatt tttaaatgag cttggactca    660

gttttagtta ttgacatgtt ggtgtgaaat ttcttcttaa gtattgcagt aatccaacag    720

aaataataga atttcgttat atttaggaag ttacaaatta tgtagtcata attttaaact    780

tgtttttcca gtagtactta ttaactttaa aaaaaaaaaa aacccagctg tgctgttcag    840

agaatgtttg taagtgttgt acagaagagg aggaaaaact acttgtgctc ttccaactgt    900

gacttttatc acatagcttg gaatttagtg ttttaaaaga tcgaatgagt cgagtgtgta    960

ttgttgtttt ggaggaggta gaagatgaat ctcctgcatt catttctaaa ttgccacagg   1020

aaaataaatc cctacattct ccaccttctg gaaatgtatt ggtaagatat ccatcactgg   1080

tgcaagctat atttaacgga gatcctgatg aagttcgagc actaatattt aagaaagaag   1140

atgttaactt tcagcagtac ttctggaata gaaattctaa acattagcct gccgaacaac   1200

tggattgcat ttgatgatta caattgtcca gtcacagatg gcatcacctc tactttttat   1260

tattaatatt agttttaatt gccaaatcat aattgtatat atttgtagag tacaatgtaa   1320

tattttggta tatgtataca atgtgggatg attaaatcaa gctaatatat ccatc        1375


<210>  9198
<211>  80
<212>  PRT
<213>  Homosapiens

<400>  9198

Met Ser Arg Val Cys Ile Val Val Leu Glu Glu Val Glu Asp Glu Ser 
1               5                   10                  15      


Pro Ala Phe Ile Ser Lys Leu Pro Gln Glu Asn Lys Ser Leu His Ser 
            20                  25                  30          


Pro Pro Ser Gly Asn Val Leu Val Arg Tyr Pro Ser Leu Val Gln Ala 
        35                  40                  45              


Ile Phe Asn Gly Asp Pro Asp Glu Val Arg Ala Leu Ile Phe Lys Lys 
    50                  55                  60                  


Glu Asp Val Asn Phe Gln Gln Tyr Phe Trp Asn Arg Asn Ser Lys His 
65                  70                  75                  80  


<210>  9199
<211>  390
<212>  DNA
<213>  Homosapiens

<400>  9199
gaatttttta gtttgatttg gattagtcac agaactggca tgaaccttct aattgtgaag     60

gctgtccaaa tgcactattt ttttctcctg ctagaggaag ttacatcccg agaagtagct    120

cagatctctg gtaagtccct acattctcca ccttctggaa atgtattggt aagatatcca    180

tcactggtgc aagctatatt taacggagat cctgatgaag ttcgagcact aatatttaag    240

aaagaagatg ttaactttca gcagtacttc tggaatagaa attctaaaca ttagcctgcc    300

gaacaactgg attgcatttg atgattacaa ttgtccagtc acagatggca tcacctctac    360

tttttattat taatattagt tttaattgcc                                     390


<210>  9200
<211>  84
<212>  PRT
<213>  Homosapiens

<400>  9200

Met Asn Leu Leu Ile Val Lys Ala Val Gln Met His Tyr Phe Phe Leu 
1               5                   10                  15      


Leu Leu Glu Glu Val Thr Ser Arg Glu Val Ala Gln Ile Ser Gly Lys 
            20                  25                  30          


Ser Leu His Ser Pro Pro Ser Gly Asn Val Leu Val Arg Tyr Pro Ser 
        35                  40                  45              


Leu Val Gln Ala Ile Phe Asn Gly Asp Pro Asp Glu Val Arg Ala Leu 
    50                  55                  60                  


Ile Phe Lys Lys Glu Asp Val Asn Phe Gln Gln Tyr Phe Trp Asn Arg 
65                  70                  75                  80  


Asn Ser Lys His 
                


<210>  9201
<211>  167
<212>  DNA
<213>  Homosapiens

<400>  9201
tacagagttc tgtcctcaga tgtgaggaaa ggacttttca aagatgagtt ctaaatgttt     60

gtttagagat ggcagcaaca agccacaggc tgtaagagga acgtgaatct accttttttt    120

gttgttgttt tttttgatac agagtcttgc tcttttgccc aggctgg                  167


<210>  9202
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  9202

Arg Trp Gln Gln Gln Ala Thr Gly Cys Lys Arg Asn Val Asn Leu Pro 
1               5                   10                  15      


Phe Phe Val Val Val Phe Phe Asp Thr Glu Ser Cys Ser Phe Ala Gln 
            20                  25                  30          


<210>  9203
<211>  378
<212>  DNA
<213>  Homosapiens

<400>  9203
tagtattttt ggtaacagga aataaatgta attctcatct ataacaactc ttattctaag     60

tttctgaatt tctctactca attgcctttt taaagtattt taactgtctt gtgctagatg    120

ttttaatatt atctttggac ttaaatcctg aggaatagaa aatacatatc tttaaattta    180

taaatagata aatctagacg agtaaaccct taccaataag aatgtcaact tacgccgggc    240

atggtggctc acgcctgtag tcccagctac tagggaggct gaggcaggag aattgcttga    300

actagggagg cagaggttgc aatgcgccaa gatcgtgccg ctgcactcca gcctggtgac    360

agagcaagac tccgtctc                                                  378


<210>  9204
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  9204

Thr Leu Thr Asn Lys Asn Val Asn Leu Arg Arg Ala Trp Trp Leu Thr 
1               5                   10                  15      


Pro Val Val Pro Ala Thr Arg Glu Ala Glu Ala Gly Glu Leu Leu Glu 
            20                  25                  30          


Leu Gly Arg Gln Arg Leu Gln Cys Ala Lys Ile Val Pro Leu His Ser 
        35                  40                  45              


Ser Leu Val Thr Glu Gln Asp Ser 
    50                  55      


<210>  9205
<211>  4208
<212>  DNA
<213>  Homosapiens

<400>  9205
aaattctaag ttgctacaag ctgcagcaag tgtgtgtcag tgggaggtga gaaaggcaaa     60

cagagggctg aaaactgagc caggaacctg cctagtggat aatcaaaact cgactataaa    120

taactaatgg aacgacgaac gtgtttagtg aagttatttt ctaaagcagc gtacaggcaa    180

aatgagtgct ttcctggagc aaatcctcaa gctgttccag aaggatattg ccaaatatca    240

gatcataaag gacaggaatt ctgaagagga taaaatcgta gacagaccat taccaaagga    300

gttggacttg gagggagtgc tgctggcaga tggcccttac ttgcaactct cttctggaat    360

ctctttttta tgcatgcagc tgtctatccc aagctcatac cagcttcctg gggcaaccaa    420

tgagtggtct acacagaagt atactctgtc atttcactcc aattcagaag aactctgaag    480

ggccatccca acttcagagc ttcccaggag gcgaacagtc agcttcaaca agcagcaggt    540

ttgatcaacc attcttctca gagcaagaaa cctaccatac tggtgtctgc agcagcaccc    600

tcaggacagc ctgcccacag ccagcgtcat cctctgtttc catgatgagg cctggtccac    660

tctcctgcgg actgtacaca gcatcctcga cacagtgccc agggccttcc tgaaggagat    720

catcctcgtg gacgacctca gccagcaagg acaactcaag tctgctctca gcgaatatgt    780

ggccaggctg gagggggtga agttactcag gagcaacaag aggctgggtg ccatcagggc    840

ccggatgctg ggggccacca gagccaccgg ggatgtgctc gtcttcatgg atgcccactg    900

cgagtgccac ccaggctggc tggagcccct cctcagcaga atagctggtg acaggagccg    960

agtggtatct ccggtgatag atgtgattga ctggaagact ttccagtatt acccctcaaa   1020

ggacctgcag cgtggggtgt tggactggaa gctggatttc cactgggaac ctttgccaga   1080

gcatgtgagg aaggccctcc agtcccccat aagccccatc aggagccctg tggtgcccgg   1140

agaggtggtg gccatggaca gacattactt ccaaaacact ggagcgtatg actctcttat   1200

gtcgctgcga ggtggtgaaa acctcgaact gtctttcaag gcctggctct gtggtggctc   1260

tgttgaaatc cttccctgct ctcgggtagg acacatctac caaaatcagg attcccattc   1320

ccccctcgac caggaggcca ccctgaggaa cagggttcgc attgctgaga cctggctggg   1380

gtcattcaaa gaaaccttct acaagcatag cccagaggcc ttctccttga gcaaggctga   1440

gaagccagac tgcatggaac gcttgcagct gcaaaggaga ctgggttgtc ggacattcca   1500

ctggtttctg gctaatgtct accctgagct gtacccatct gaacccaggc ccagtttctc   1560

tggaaagctc cacaacactg gacttgggct ctgtgcagac tgccaggcag aaggggacat   1620

cctgggctgt cccatggtgt tggctccttg cagtgacagc cggcagcaac agtacctgca   1680

gcacaccagc aggaaggaga ttcactttgg cagcccacag cacctgtgct ttgctgtcag   1740

gcaggagcag gtgattcttc agaactgcac ggaggaaggc ctggccatcc accagcagca   1800

ctgggacttc caggagaatg ggatgattgt ccacattctt tctgggaaat gcatggaagc   1860

tgtggtgcaa gaaaacaata aagatttgta cctgcgtccg tgtgatggaa aagcccgcca   1920

gcagtggcgt tttgaccaga tcaatgctgt ggatgaacga tgaatgtcaa tgtcagaagg   1980

aaaagagaat tttggccatc aaaatccagc tccaagtgaa cttaaagagc ttatatattt   2040

catgaagctg atccttttgt gtgtgtgctc ctggtgttag gagagaaaaa agctctatga   2100

aagaatatag gaagtttctc cttttcacac cttatttcat tgactgctgg ctgctttaaa   2160

aaaaaaaaaa aaggatccat tgtaccgttg tcttcatcac tgggaaatga ttattacata   2220

gtacagaaga ttctttgttt ttctccactg agcacttaac aattgctttc tctctggcct   2280

ggacattctc tggcagcacc tccaggatac ataaattcaa tggatcaatt tatttgtctt   2340

caaatggcct taacttggat tgtctgtttg gccaaccatg aaaattaaag agtgaagcag   2400

atgtaatggc ctgacattcc aaaaactctg aattgggttt attagcacaa atgttgtgtt   2460

catttgttga gccatatctc agaagaagga aagggagcta cagaaaggag gtttaggatt   2520

gcagagaaga tgcaagagca ctttggccca attctccagc tcaacccagc agctgaaaag   2580

cttcaagaga tctaggaaaa gacattttca tgttaatgag aatttccacc attgtagaga   2640

atttccttcc tactgagaat ctacctctat tccccctgcc ctagctcttc tctaacttgg   2700

ttaaccataa ccataaccag attcccttgc aatcgatttc tctttagtcg ttggtgttag   2760

aagtaccagc acaatttgag cattcccatt aacaaaggtg ttcacagttg agaaactctc   2820

ctgccgggcg cggtggctca tgcctgtaat tccagcactt tgggaggcag agttgggagg   2880

atcacctgat gtcaggggtt tgagaccagc ctggtcaaca ttgcaaaacc ttgtctctac   2940

taaaaataca aaaattagct gggcatggtg gcgcatacct gtaatcccag ctacttggga   3000

ggctgaggca agagaatcgc ttgaacccag gaggcagagg ttgcagtgag ctgagatcat   3060

gccattgcac tccaacctgg gtgacagagt gagactccat ctcaaaaaaa aaaaaaaaga   3120

gagaaactct cctgatgccc tgttacaggg tttgcactga ctggagcaga aacagcaacc   3180

tttctaaaaa agcaaacctt tttcctggga ggaaaatgcc agagcctgag ccaaaattct   3240

tatgacaggt aacatttggg tgttaatgtc catgagagct gacagggcca tctctgagcc   3300

catataactg tctggaaccc ccaaatgtgt ccacaggttg aatgtccatg agtgtgggaa   3360

gaacacggct catctggagc acagctgagg ctagtaagag ctaaatgact ttccttgcta   3420

tgacttggct tacctgaatt agctgtaaga gttgccgaat gggatgggtt ctgctattta   3480

ataaacagca ttcatattca tttttcccca gatggagtta cctacctttc cacatggtca   3540

gcttagaaat cttcccctaa agatgctaat ctcctttggg ctgtctcaga acacagtatc   3600

cttcaaataa gaaaaactga gtgggaagtg cagtgtttcc aaacaatacc tatcataact   3660

acgtattcat tgtctacctg ctaagtcaag ggttcactgc atttctcctt cctcagaata   3720

cactctggac ctgtgctgtc taatatggta gccactaaca aaatgtggcc attttgatgg   3780

aaatccatta aaatcaaaga aaatttaaaa ctcaattcct caattgggct ggccacattt   3840

caaatgctca ctacccacct gtggctaggg tctacttcta ctgtattggc gagcatggat   3900

atagaacatt tcatcacagt tctgttggac caatctagat agattcatta tcccatctag   3960

agaagagact ttagtcactg tcttcttgct tcagacccat ctatatttaa aacaaatttc   4020

cctaaatcct gagactgaga cggagctaca aattctcaga tggcgaccgt gtaaatggta   4080

ttagcggctg aagaaaaaaa atttttcaag acctctgttt tttaactgaa ctttatcatt   4140

ggcattgtgg gtctttgaag ttgctgggat aaattaatat aattaaataa aagactgaat   4200

ttaattgc                                                            4208


<210>  9206
<211>  372
<212>  PRT
<213>  Homosapiens

<400>  9206

Met Leu Gly Ala Thr Arg Ala Thr Gly Asp Val Leu Val Phe Met Asp 
1               5                   10                  15      


Ala His Cys Glu Cys His Pro Gly Trp Leu Glu Pro Leu Leu Ser Arg 
            20                  25                  30          


Ile Ala Gly Asp Arg Ser Arg Val Val Ser Pro Val Ile Asp Val Ile 
        35                  40                  45              


Asp Trp Lys Thr Phe Gln Tyr Tyr Pro Ser Lys Asp Leu Gln Arg Gly 
    50                  55                  60                  


Val Leu Asp Trp Lys Leu Asp Phe His Trp Glu Pro Leu Pro Glu His 
65                  70                  75                  80  


Val Arg Lys Ala Leu Gln Ser Pro Ile Ser Pro Ile Arg Ser Pro Val 
                85                  90                  95      


Val Pro Gly Glu Val Val Ala Met Asp Arg His Tyr Phe Gln Asn Thr 
            100                 105                 110         


Gly Ala Tyr Asp Ser Leu Met Ser Leu Arg Gly Gly Glu Asn Leu Glu 
        115                 120                 125             


Leu Ser Phe Lys Ala Trp Leu Cys Gly Gly Ser Val Glu Ile Leu Pro 
    130                 135                 140                 


Cys Ser Arg Val Gly His Ile Tyr Gln Asn Gln Asp Ser His Ser Pro 
145                 150                 155                 160 


Leu Asp Gln Glu Ala Thr Leu Arg Asn Arg Val Arg Ile Ala Glu Thr 
                165                 170                 175     


Trp Leu Gly Ser Phe Lys Glu Thr Phe Tyr Lys His Ser Pro Glu Ala 
            180                 185                 190         


Phe Ser Leu Ser Lys Ala Glu Lys Pro Asp Cys Met Glu Arg Leu Gln 
        195                 200                 205             


Leu Gln Arg Arg Leu Gly Cys Arg Thr Phe His Trp Phe Leu Ala Asn 
    210                 215                 220                 


Val Tyr Pro Glu Leu Tyr Pro Ser Glu Pro Arg Pro Ser Phe Ser Gly 
225                 230                 235                 240 


Lys Leu His Asn Thr Gly Leu Gly Leu Cys Ala Asp Cys Gln Ala Glu 
                245                 250                 255     


Gly Asp Ile Leu Gly Cys Pro Met Val Leu Ala Pro Cys Ser Asp Ser 
            260                 265                 270         


Arg Gln Gln Gln Tyr Leu Gln His Thr Ser Arg Lys Glu Ile His Phe 
        275                 280                 285             


Gly Ser Pro Gln His Leu Cys Phe Ala Val Arg Gln Glu Gln Val Ile 
    290                 295                 300                 


Leu Gln Asn Cys Thr Glu Glu Gly Leu Ala Ile His Gln Gln His Trp 
305                 310                 315                 320 


Asp Phe Gln Glu Asn Gly Met Ile Val His Ile Leu Ser Gly Lys Cys 
                325                 330                 335     


Met Glu Ala Val Val Gln Glu Asn Asn Lys Asp Leu Tyr Leu Arg Pro 
            340                 345                 350         


Cys Asp Gly Lys Ala Arg Gln Gln Trp Arg Phe Asp Gln Ile Asn Ala 
        355                 360                 365             


Val Asp Glu Arg 
    370         


<210>  9207
<211>  5043
<212>  DNA
<213>  Homosapiens

<400>  9207
aaattctaag ttgctacaag ctgcagcaag tgtgtgtcag tgggaggtga gaaaggcaaa     60

cagagggctg aaaactgagc caggaacctg cctagtggat aatcaaaact cgactataaa    120

taactaatgg aacgacgaac gtgtttagtg aagttatttt ctaaagcagc gtacaggcaa    180

aatgagtgct ttcctggagc aaatcctcaa gctgttccag aaggatattg ccaaatatca    240

gatcataaag gacaggaatt ctgaagagga taaaatcgta gacagaccat taccaaagga    300

gttggacttg gagggagtgc tgctggcaga tggcccttac ttgcaactct cttctggaat    360

ctctttttta tgcatgcagc tgtctatccc aagctcatac cagcttcctg gggcaaccaa    420

tgagtggtct acacagaagt atactctgtc atttcactcc aattcagaag aactctgaag    480

ggccatccca acttcagagc ttcccaggag gcgaacagtc agcttcaaca agcagcaggt    540

ttgatcaacc attcttctca gagcaagaaa cctaccatac tggtgtctgc agcagcaccc    600

tcaggacagc ctgcccacag ccagcgtcat cctctgtttc catgatgagg cctggtccac    660

tctcctgcgg actgtacaca gcatcctcga cacagtgccc agggccttcc tgaaggagat    720

catcctcgtg gacgacctca gccagcaagg acaactcaag tctgctctca gcgaatatgt    780

ggccaggctg gagggggtga agttactcag gagcaacaag aggctgggtg ccatcagggc    840

ccggatgctg ggggccacca gagccaccgg ggatgtgctc gtcttcatgg atgcccactg    900

cgagtgccac ccaggctggc tggagcccct cctcagcaga atagctggtg acaggagccg    960

agtggtatct ccggtgatag atgtgattga ctggaagact ttccagtatt acccctcaaa   1020

ggacctgcag cgtggggtgt tggactggaa gctggatttc cactgggaac ctttgccaga   1080

gcatgtgagg aaggccctcc agtcccccat aagccccatc aggagccctg tggtgcccgg   1140

agaggtggtg gccatggaca gacattactt ccaaaacact ggagcgtatg actctcttat   1200

gtcgctgcga ggtggtgaaa acctcgaact gtctttcaag gcctggctct gtggtggctc   1260

tgttgaaatc cttccctgct ctcgggtagg acacatctac caaaatcagg attcccattc   1320

ccccctcgac caggaggcca ccctgaggaa cagggttcgc attgctgaga cctggctggg   1380

gtcattcaaa gaaaccttct acaagcatag cccagaggcc ttctccttga gcaaggctga   1440

gaagccagac tgcatggaac gcttgcagct gcaaaggaga ctgggttgtc ggacattcca   1500

ctggtttctg gctaatgtct accctgagct gtacccatct gaacccaggc ccagtttctc   1560

tggaaagctc cacaacactg gacttgggct ctgtgcagac tgccaggcag aaggggacat   1620

cctgggctgt cccatggtgt tggctccttg cagtgacagc cggcagcaac agtacctgca   1680

gcacaccagc aggaaggaga ttcactttgg cagcccacag cacctgtgct ttgctgtcag   1740

gcaggagcag gtgattcttc agaactgcac ggaggaaggc ctggccatcc accagcagca   1800

ctgggacttc caggagaatg ggatgattgt ccacattctt tctgggaaat gcatggaagc   1860

tgtggtgcaa gaaaacaata aagatttgta cctgcgtccg tgtgatggaa aagcccgcca   1920

gcagtggcgt tttgaccaga tcaatgctgt ggatgaacga tgaatgtcaa tgtcagaagg   1980

aaaagagaat tttggccatc aaaatccagc tccaagtgaa cttaaagagc ttatatattt   2040

catgaagctg atccttttgt gtgtgtgctc ctggtgttag gagagaaaaa agctctatga   2100

aagaatatag gaagtttctc cttttcacac cttatttcat tgactgctgg ctgctttaaa   2160

aaaaaaaaaa aaggatccat tgtaccgttg tcttcatcac tgggaaatga ttattacata   2220

gtacagaaga ttctttgttt ttctccactg agcacttaac aattgctttc tctctggcct   2280

ggacattctc tggcagcacc tccaggatac ataaattcaa tggatcaatt tatttgtctt   2340

caaatggcct taacttggat tgtctgtttg gccaaccatg aaaattaaag agtgaagcag   2400

atgtaatggc ctgacattcc aaaaactctg aattgggttt attagcacaa atgttgtgtt   2460

catttgttga gccatatctc agaagaagga aagggagcta cagaaaggag gtttaggatt   2520

gcagagaaga tgcaagagca ctttggccca attctccagc tcaacccagc agctgaaaag   2580

cttcaagaga tctaggaaaa gacattttca tgttaatgag aatttccacc attgtagaga   2640

atttccttcc tactgagaat ctacctctat tccccctgcc ctagctcttc tctaacttgg   2700

ttaaccataa ccataaccag attcccttgc aatcgatttc tctttagtcg ttggtgttag   2760

aagtaccagc acaatttgag cattcccatt aacaaaggtg ttcacagttg agaaactctc   2820

ctgccgggcg cggtggctca tgcctgtaat tccagcactt tgggaggcag agttgggagg   2880

atcacctgat gtcaggggtt tgagaccagc ctggtcaaca ttgcaaaacc ttgtctctac   2940

taaaaataca aaaattagct gggcatggtg gcgcatacct gtaatcccag ctacttggga   3000

ggctgaggca agagaatcgc ttgaacccag gaggcagagg ttgcagtgag ctgagatcat   3060

gccattgcac tccaacctgg gtgacagagt gagactccat ctcaaaaaaa aaaaaaaaga   3120

gagaaactct cctgatgccc tgttacaggg tttgcactga ctggagcaga aacagcaacc   3180

tttctaaaaa agcaaacctt tttcctggga ggaaaatgcc agagcctgag ccaaaattct   3240

tatgacaggt aacatttggg tgttaatgtc catgagagct gacagggcca tctctgagcc   3300

catataactg tctggaaccc ccaaatgtgt ccacaggttg aatgtccatg agtgtgggaa   3360

gaacacggct catctggagc acagctgagg ctagtaagag ctaaatgact ttccttgcta   3420

tgacttggct tacctgaatt agctgtaaga gttgccgaat gggatgggtt ctgctattta   3480

ataaacagca ttcatattca tttttcccca gatggagtta cctacctttc cacatggtca   3540

gcttagaaat cttcccctaa agatgctaat ctcctttggg ctgtctcaga acacagtatc   3600

cttcaaataa gaaaaactga gtgggaagtg cagtgtttcc aaacaatacc tatcataact   3660

acgtattcat tgtctacctg ctaagtcaag ggttcactgc atttctcctt cctcagaata   3720

cactctggac ctgtgctgtc taatatggta gccactaaca aaatgtggcc attttgatgg   3780

aaatccatta aaatcaaaga aaatttaaaa ctcaattcct caattgggct ggccacattt   3840

caaatgctca ctacccacct gtggctaggg tctacttcta ctgtattggc gagcatggat   3900

atagaacatt tcatcacagt tctgttggac caatctagat agattcatta tcccatctag   3960

agaagagact ttagtcactg tcttcttgct tcagacccat ctatatttaa aacaaatttc   4020

cctaaatcct gagactgaga cggagctaca aattctcaga tggcgaccgt gtaaatggta   4080

ttagcggctg aagaaaaaaa atttttcaag acctctgttt tttaactgaa ctttatcatt   4140

ggcattgtgg gtctttgaag ttgctgggat aaattaatat aattaaataa aagactgaat   4200

ttaattgcat aaattgtatt aggtggcaat taacaaaagg acccagatgg cttattgcct   4260

aattgggtga acaaagcaag aatatggtgt ttcttgcttc cttaaccagc tccatgattt   4320

attactttat tgcagaagtg gctgtcaact cagtccctgg ctggtattta cagaccctta   4380

atttaagtaa aacagatgcc tccatttagt tctagaagga ccttctcctt tagtgtaacc   4440

aagtgttcaa attcccttct tctctatgaa ctcagcattc attttatcca taatgatcaa   4500

tttaaaagta gagaaacttg tcagttgaga gatctgattc ccaagagatt ggtttcactt   4560

gtctacctga attttgtgat tggattttgt tgttcgtttt ttaagattga attttgttac   4620

cacccccacc aagttcatca tcattattaa ctataccact ggggagaaca gagagaagtg   4680

tccggccagc agtctagagt cccacactct tcatgctgta ttacaacagt aagagcagat   4740

atccttcctg gagagtgcct gacctgtttc ctctttggtt ttaatgccat agatcccact   4800

ggaaaattca gaattccaac taacaaagac atggtggttg aaaagtcctc agtgacaata   4860

atgatggcac cactgcagca gaacttgaca ttttagaggt catgttattg tgcttaatgt   4920

gagggggttc tattctctac tgaaaggcta tgaaaaagcc agttggacac caagtgatct   4980

gtgaccagtc accaaatttg gacaaacaaa atgcaaacaa gttgcatttt taaaaagcat   5040

tca                                                                 5043


<210>  9208
<211>  372
<212>  PRT
<213>  Homosapiens

<400>  9208

Met Leu Gly Ala Thr Arg Ala Thr Gly Asp Val Leu Val Phe Met Asp 
1               5                   10                  15      


Ala His Cys Glu Cys His Pro Gly Trp Leu Glu Pro Leu Leu Ser Arg 
            20                  25                  30          


Ile Ala Gly Asp Arg Ser Arg Val Val Ser Pro Val Ile Asp Val Ile 
        35                  40                  45              


Asp Trp Lys Thr Phe Gln Tyr Tyr Pro Ser Lys Asp Leu Gln Arg Gly 
    50                  55                  60                  


Val Leu Asp Trp Lys Leu Asp Phe His Trp Glu Pro Leu Pro Glu His 
65                  70                  75                  80  


Val Arg Lys Ala Leu Gln Ser Pro Ile Ser Pro Ile Arg Ser Pro Val 
                85                  90                  95      


Val Pro Gly Glu Val Val Ala Met Asp Arg His Tyr Phe Gln Asn Thr 
            100                 105                 110         


Gly Ala Tyr Asp Ser Leu Met Ser Leu Arg Gly Gly Glu Asn Leu Glu 
        115                 120                 125             


Leu Ser Phe Lys Ala Trp Leu Cys Gly Gly Ser Val Glu Ile Leu Pro 
    130                 135                 140                 


Cys Ser Arg Val Gly His Ile Tyr Gln Asn Gln Asp Ser His Ser Pro 
145                 150                 155                 160 


Leu Asp Gln Glu Ala Thr Leu Arg Asn Arg Val Arg Ile Ala Glu Thr 
                165                 170                 175     


Trp Leu Gly Ser Phe Lys Glu Thr Phe Tyr Lys His Ser Pro Glu Ala 
            180                 185                 190         


Phe Ser Leu Ser Lys Ala Glu Lys Pro Asp Cys Met Glu Arg Leu Gln 
        195                 200                 205             


Leu Gln Arg Arg Leu Gly Cys Arg Thr Phe His Trp Phe Leu Ala Asn 
    210                 215                 220                 


Val Tyr Pro Glu Leu Tyr Pro Ser Glu Pro Arg Pro Ser Phe Ser Gly 
225                 230                 235                 240 


Lys Leu His Asn Thr Gly Leu Gly Leu Cys Ala Asp Cys Gln Ala Glu 
                245                 250                 255     


Gly Asp Ile Leu Gly Cys Pro Met Val Leu Ala Pro Cys Ser Asp Ser 
            260                 265                 270         


Arg Gln Gln Gln Tyr Leu Gln His Thr Ser Arg Lys Glu Ile His Phe 
        275                 280                 285             


Gly Ser Pro Gln His Leu Cys Phe Ala Val Arg Gln Glu Gln Val Ile 
    290                 295                 300                 


Leu Gln Asn Cys Thr Glu Glu Gly Leu Ala Ile His Gln Gln His Trp 
305                 310                 315                 320 


Asp Phe Gln Glu Asn Gly Met Ile Val His Ile Leu Ser Gly Lys Cys 
                325                 330                 335     


Met Glu Ala Val Val Gln Glu Asn Asn Lys Asp Leu Tyr Leu Arg Pro 
            340                 345                 350         


Cys Asp Gly Lys Ala Arg Gln Gln Trp Arg Phe Asp Gln Ile Asn Ala 
        355                 360                 365             


Val Asp Glu Arg 
    370         


<210>  9209
<211>  4615
<212>  DNA
<213>  Homosapiens

<400>  9209
atgcgcagcc aggccccagc ctgttggcca gggcgggatc aaccacagga aggaaccagc     60

tgcagctggg cgtgggtgcc ttccccgtgg aaagccgctg gcagggagtc tacagcccct    120

tccgggactt tgtgtgtgct ggctgcccca gggacctgca ggaggccctg ctgggcttcg    180

acgtgcagag ctccagggag ctgcgtaggt ctcaggatta cctgtcctgc gagaggtgag    240

gccggctgtg tgagcatgca caggttaggg tgggctgggg agggcttcct ggggggaggg    300

ggctgggccg aggtgtgggt gagggatgct gtgtgtggtg cccaggaccc accctgagga    360

cagtgtgggc agtatggaag acatcctgga ggagctgctg cagcaccggg agcccaaggc    420

cctgcagctg tacctcagga aggctctgag caactcactg caccccctgg gaaagctgct    480

ccggacactg atgctgacct tccaggctac ctacgcaggt gtcggggcca acaagcacct    540

gcaggagctg gcccaggagg aggtgaagca gcatgcccag gaactctggg ctgcctacag    600

gctgagcttg gccctggact cggaacacac ctgcagtccc aggctgggct gtgaccccat    660

gaaacactgc aaatagaagc cttagatgct atagttcctt ctgctgctgg attctcaggc    720

taacatcctg gagctccaac cttctaactt ctgtggtttg agaggatgaa ccctgcaggc    780

catgtccaca gttctgagag gccacctgct tttgcctttg ttgactggtg gtagaactcc    840

agttctgtgg caaggggcag ccacaccatt tctctctcat tgactcacag gggtctgctg    900

cgagttgcct tagagcgcaa gggccaggcc ctggaggagg atgaagacac agagacaagg    960

tgactggcgc aggtctcctt ggggcctgcc gtgtccaggg aggcctcatg cgtctgctcc   1020

taggacctcc cttggggaaa gaggtgcttc tggggaagtg ctgggcattc actctattga   1080

ccaaacattg tgcattgatc gtttgtggat tagaatgacc catgacctct gttctgtgag   1140

gaaccaggga gggggcactg ctacaatgca ttgaatgcat ctttgttcta aatgtatgat   1200

cccaatctca tctttcgcat gcagaaggtg agtagctccc cgaggcaccc tcctctccct   1260

gcacacagat ggggaaaccg agggctggta gggatgagcc tgaggttata caggagttag   1320

gtgggcatga aatttgtttc ccccagtccc tggagcaaac cttacaattt gcctttagat   1380

tctagacctg aaagtgttcc tgatcagaga ggccttcctg tcactgcctt gcaggaggca   1440

agggaaatgg ggttagacat tagggaggat tccccgcccg gagtcctagc acagcaaacc   1500

aggaggtgga actgaatcag cctggaatgg ctgctgagag ctcagctgca agttgctggt   1560

ccatctgggg ccctggtttt gctttcagtc aaatggggat ccaactcctg ccccacctgc   1620

catcttggtt gtcaaagtca aaggagggaa tgaagttatg aattgaattg ggcaaatgat   1680

gactgagaac aggcttggaa aaggttttct ggggaggagg aggctggagg ccaggacact   1740

gtttgttgtg gaactaggag ctctttgaga cgagactcca agtagtaatc ccagacccca   1800

ccttgctcat cccaacctgt tccggtctcc ccatcaggga cctccaggtg catggattgg   1860

tgctgcccct catgctgccc agcttctact cagagctctt cacgctctac ctgctgcttc   1920

atgagcggga ggacagcttc tacagccagg gcattgccaa cttgagcctc tttcctgata   1980

cccaactgct cgagttcctg gatgtgcaga agcacttgtg gcccctcaag gacctcacgc   2040

tgacgagcaa tcagaggtac tccctggtca gggacaagtg tttcctgtca gccaccgagt   2100

gcctgcagaa gatcatgacc acggtggacc cacgggagaa gctggaggtg ctggagagga   2160

catacgggga aattgagggc acggtgtcga gggtattggg ccgggagtac aagctgccca   2220

tggacgacct gctgccactt ctcatctacg tggtgtcgcg cgcccgatgg ggaagccaag   2280

gcccagaaaa gggagggtcc cagccagggt gctggggtgc tagaggtaga gtgaggacca   2340

caccccaggt gtccagccat ccaggccagc gctccttccc cagctgcctg tccgcgacag   2400

gcctcttctc cttgtctccc tcgctctctt ggtggggcgg tgttctccag aattcagcac   2460

ctgggagccg agatccacct gatccgtgac atgatggacc ccaaccacac aggaggcctg   2520

tatgacttcc tgctcacagc cctggagtcc tgttacgagc acatccagaa agaagacatg   2580

aggctgcacc gcttacctgg ccactggcac tccagggagc tctggtagcc tggcctttcc   2640

tggacagact gaagagctga gcagggcact gccagcctgt ccctcattac ccaaggcaag   2700

gggcaggaca ggccctcaga agcagctctt ggaggagatg agcattttgt tttgcacagg   2760

aagatgctgc tgctgccctg actgggatga gggtgagggg tgacgggtgt ggccctggat   2820

gtggtggttt tcccttggcc actagcccat cttcaatgac cccttaatct gcagcagctc   2880

acaggctggg ggtgaggagt ccctggcttc tcttagcctg agcctttctc ccaagttcca   2940

gagcctctcc gggcctcagt gctgccatct gtacaatggt ggagtgagta cgctgtaaag   3000

gaccttccat tcattttgct gaattccaga gtccttttgg aaaactgact ttagtctgct   3060

gggctgtatt gacctctggc aggctcgaag cctcactggg tatgcagtca acaggatggg   3120

cctggagatc cgtgaactgc aggccacgta cccatgacgt aaacggcggc actggagcaa   3180

gctggggcgg ggggtgggta aaccctcact gccagcaggc cccaagtggc ttgtaaatca   3240

ttctcctgtg atgtctgtgg gcctgcgtgg ggacaacagg ggcacatgac atctgcctgg   3300

gccctgacca ataaaccctc agacccagga cccaggaccc tgctgtagtt ggggagcagg   3360

agtacctttg ggaggggagg actttattta aacagtggtt ctagtgtggg accaagagag   3420

gcaggagctg ggtcttgggg cagctttatt cctgttgggc ctcagtttct cttccccaca   3480

cagtttatct tccgtcacat tgtgccgggt gacgtgcacg gtctccctct gccctagccg   3540

gagatgcatg atgacaggca gtgtgatgtg ttctgaaagt gtccagggca aagcgtaggg   3600

agagggtgga tttgtgcagg gtgcagctct ggagaagaag ctggatcact cttggtccca   3660

ttccctaggc cctgagcaag tcaggctcct ggctctgggt gtggctcccc caaacgaagt   3720

actgacttca gcctgtgagg ggagggttga gggaggctct ggaaagccca gccacacctg   3780

agtccctggc agtagccttg gggcagaggg cacccgcaga gtcccagaga tgatgtgggc   3840

agtgggcaga gagagccttg gcgcctctgt ttgccaccac ttccccagga aggagggaca   3900

gcatttctct ggctggttcc actaaatgtg ccagcccaaa tgcagggcat gggctctggt   3960

tctgccagga gcctgtgaca cccccaggaa gggggtggaa ctgaggaaga gcgaggatat   4020

gcaggcactc atgcttaccg ggactggggc agctcactag gattctatcc tttccaatcg   4080

gcatcagcca gctcttgtcc cctgataagt gaggacagcc tgaccctggc ctcaaatgca   4140

gccatccctg agttcatgcg atgctgacgg gaccccagca cacttccctg cctcctttga   4200

gatctgcgag cccttgctgc agttcagatt caacaaggcc ctctgcccac cctctcacta   4260

ggcctcaccc aacaccagtg gaactggagc ctctggctgg gcacagtggc tcactttggg   4320

aggctgaggc aggaaggctg ctggaaactg agagttcaag accagcctgg gcaacatagt   4380

gagaccctgt ctctacaaat acaaaataaa ataattagct gggtgtgttg gtgtgtgcct   4440

gtggtcccag ctactcggga ggctgaggtg ggaagatccc tgagcctgga gggtcgaggt   4500

tgcagtgagc ggagatcgca cctctgcact caatcctggg tgacaaaatg aaaccctgcc   4560

tcaaaaataa aaataaaaat aaaaataaaa taaataaaaa agagcatctg gacag        4615


<210>  9210
<211>  205
<212>  PRT
<213>  Homosapiens

<400>  9210

Met Leu Pro Ser Phe Tyr Ser Glu Leu Phe Thr Leu Tyr Leu Leu Leu 
1               5                   10                  15      


His Glu Arg Glu Asp Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser 
            20                  25                  30          


Leu Phe Pro Asp Thr Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His 
        35                  40                  45              


Leu Trp Pro Leu Lys Asp Leu Thr Leu Thr Ser Asn Gln Arg Tyr Ser 
    50                  55                  60                  


Leu Val Arg Asp Lys Cys Phe Leu Ser Ala Thr Glu Cys Leu Gln Lys 
65                  70                  75                  80  


Ile Met Thr Thr Val Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg 
                85                  90                  95      


Thr Tyr Gly Glu Ile Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu 
            100                 105                 110         


Tyr Lys Leu Pro Met Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val 
        115                 120                 125             


Ser Arg Ala Arg Trp Gly Ser Gln Gly Pro Glu Lys Gly Gly Ser Gln 
    130                 135                 140                 


Pro Gly Cys Trp Gly Ala Arg Gly Arg Val Arg Thr Thr Pro Gln Val 
145                 150                 155                 160 


Ser Ser His Pro Gly Gln Arg Ser Phe Pro Ser Cys Leu Ser Ala Thr 
                165                 170                 175     


Gly Leu Phe Ser Leu Ser Pro Ser Leu Ser Trp Trp Gly Gly Val Leu 
            180                 185                 190         


Gln Asn Ser Ala Pro Gly Ser Arg Asp Pro Pro Asp Pro 
        195                 200                 205 


<210>  9211
<211>  2640
<212>  DNA
<213>  Homosapiens

<400>  9211
atcccagacc ccaccttgct catcccaacc tgttccggtc tccccatcag ggacctccag     60

gtgcatggat tggtgctgcc cctcatgctg cccagcttct actcagagct cttcacgctc    120

tacctgctgc ttcatgagcg ggaggacagc ttctacagcc agggcattgc caacttgagc    180

ctctttcctg atacccaact gctcgagttc ctggatgtgc agaagcactt gtggcccctc    240

aaggacctca cgctgacgag caatcagagg tactccctgg tcagggacaa gtgtttcctg    300

tcagccaccg agtgcctgca gaagatcatg accacggtgg acccacggga gaagctggag    360

gtgctggaga ggacatacgg ggaaattgag ggcacggtgt cgagggtatt gggccgggag    420

tacaagctgc ccatggacga cctgctgcca cttctcatct acgtggtgtc gcgcgcccga    480

attcagcacc tgggagccga gatccacctg atccgtgaca tgatggaccc caaccacaca    540

ggaggcctgt atgacttcct gctcacagcc ctggagtcct gttacgagca catccagaaa    600

gaagacatga ggctgcaccg cttacctggc cactggcact ccagggagct ctggtagcct    660

ggcctttcct ggacagactg aagagctgag cagggcactg ccagcctgtc cctcattacc    720

caaggcaagg ggcaggacag gccctcagaa gcagctcttg gaggagatga gcattttgtt    780

ttgcacagga agatgctgct gctgccctga ctgggatgag ggtgaggggt gacgggtgtg    840

gccctggatg tggtggtttt cccttggcca ctagcccatc ttcaatgacc ccttaatctg    900

cagcagctca caggctgggg gtgaggagtc cctggcttct cttagcctga gcctttctcc    960

caagttccag agcctctccg ggcctcagtg ctgccatctg tacaatggtg gagtgagtac   1020

gctgtaaagg accttccatt cattttgctg aattccagag tccttttgga aaactgactt   1080

tagtctgctg ggctgtattg acctctggca ggctcgaagc ctcactgggt atgcagtcaa   1140

caggatgggc ctggagatcc gtgaactgca ggccacgtac ccatgacgta aacggcggca   1200

ctggagcaag ctggggcggg gggtgggtaa accctcactg ccagcaggcc ccaagtggct   1260

tgtaaatcat tctcctgtga tgtctgtggg cctgcgtggg gacaacaggg gcacatgaca   1320

tctgcctggg ccctgaccaa taaaccctca gacccaggac ccaggaccct gctgtagttg   1380

gggagcagga gtacctttgg gaggggagga ctttatttaa acagtggttc tagtgtggga   1440

ccaagagagg caggagctgg gtcttggggc agctttattc ctgttgggcc tcagtttctc   1500

ttccccacac agtttatctt ccgtcacatt gtgccgggtg acgtgcacgg tctccctctg   1560

ccctagccgg agatgcatga tgacaggcag tgtgatgtgt tctgaaagtg tccagggcaa   1620

agcgtaggga gagggtggat ttgtgcaggg tgcagctctg gagaagaagc tggatcactc   1680

ttggtcccat tccctaggcc ctgagcaagt caggctcctg gctctgggtg tggctccccc   1740

aaacgaagta ctgacttcag cctgtgaggg gagggttgag ggaggctctg gaaagcccag   1800

ccacacctga gtccctggca gtagccttgg ggcagagggc acccgcagag tcccagagat   1860

gatgtgggca gtgggcagag agagccttgg cgcctctgtt tgccaccact tccccaggaa   1920

ggagggacag catttctctg gctggttcca ctaaatgtgc cagcccaaat gcagggcatg   1980

ggctctggtt ctgccaggag cctgtgacac ccccaggaag ggggtggaac tgaggaagag   2040

cgaggatatg caggcactca tgcttaccgg gactggggca gctcactagg attctatcct   2100

ttccaatcgg catcagccag ctcttgtccc ctgataagtg aggacagcct gaccctggcc   2160

tcaaatgcag ccatccctga gttcatgcga tgctgacggg accccagcac acttccctgc   2220

ctcctttgag atctgcgagc ccttgctgca gttcagattc aacaaggccc tctgcccacc   2280

ctctcactag gcctcaccca acaccagtgg aactggagcc tctggctggg cacagtggct   2340

cactttggga ggctgaggca ggaaggctgc tggaaactga gagttcaaga ccagcctggg   2400

caacatagtg agaccctgtc tctacaaata caaaataaaa taattagctg ggtgtgttgg   2460

tgtgtgcctg tggtcccagc tactcgggag gctgaggtgg gaagatccct gagcctggag   2520

ggtcgaggtt gcagtgagcg gagatcgcac ctctgcactc aatcctgggt gacaaaatga   2580

aaccctgcct caaaaataaa aataaaaata aaaataaaat aaataaaaaa gagcatctgg   2640


<210>  9212
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  9212

Met Leu Pro Ser Phe Tyr Ser Glu Leu Phe Thr Leu Tyr Leu Leu Leu 
1               5                   10                  15      


His Glu Arg Glu Asp Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser 
            20                  25                  30          


Leu Phe Pro Asp Thr Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His 
        35                  40                  45              


Leu Trp Pro Leu Lys Asp Leu Thr Leu Thr Ser Asn Gln Arg Tyr Ser 
    50                  55                  60                  


Leu Val Arg Asp Lys Cys Phe Leu Ser Ala Thr Glu Cys Leu Gln Lys 
65                  70                  75                  80  


Ile Met Thr Thr Val Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg 
                85                  90                  95      


Thr Tyr Gly Glu Ile Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu 
            100                 105                 110         


Tyr Lys Leu Pro Met Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val 
        115                 120                 125             


Ser Arg Ala Arg Ile Gln His Leu Gly Ala Glu Ile His Leu Ile Arg 
    130                 135                 140                 


Asp Met Met Asp Pro Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu 
145                 150                 155                 160 


Thr Ala Leu Glu Ser Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg 
                165                 170                 175     


Leu His Arg Leu Pro Gly His Trp His Ser Arg Glu Leu Trp 
            180                 185                 190 


<210>  9213
<211>  3318
<212>  DNA
<213>  Homosapiens

<400>  9213
aggaaggaac cagctgtaag ggagggcaga gggggatgtc ttggagggga atcccagact     60

ttggacactg gtctctcttg gaccaagacc ccctctctgg cttggcctcc agatctgccc    120

acctttctgt ctccgtcttt ccaggattcc atatgcttct gtctgtcttc tcgtcgcagg    180

gtagattctc tgtccctttc tctgctgctc ttcctcctgg agccgtggag gcagctgggc    240

gtgggtgcct tccccgtgga aagccgctgg cagggagtct acagcccctt ccgggacttt    300

gtgtgtgctg gctgccccag ggacctgcag gaggccctgc tgggcttcga cgtgcagagc    360

tccagggagc tgcgtaggtc tcaggattac ctgtcctgcg agaggaccca ccctgaggac    420

agtgtgggca gtatggaaga catcctggag gagctgctgc agcaccggga gcccaaggcc    480

ctgcagctgt acctcaggaa ggctctgagc aactcactgc accccctggg aaagctgctc    540

cggacactga tgctgacctt ccaggctacc tacgcaggtg tcggggccaa caagcacctg    600

caggagctgg cccaggagga ggtgaagcag catgcccagg aactctgggc tgcctacagg    660

ggtctgctgc gagttgcctt agagcgcaag ggccaggccc tggaggagga tgaagacaca    720

gagacaaggg acctccaggt gcatggattg gtgctgcccc tcatgctgcc cagcttctac    780

tcagagctct tcacgctcta cctgctgctt catgagcggg aggacagctt ctacagccag    840

ggcattgcca acttgagcct ctttcctgat acccaactgc tcgagttcct ggatgtgcag    900

aagcacttgt ggcccctcaa ggacctcacg ctgacgagca atcagaggta ctccctggtc    960

agggacaagt gtttcctgtc agccaccgag tgcctgcaga agatcatgac cacggtggac   1020

ccacgggaga agctggaggt gctggagagg acatacgggg aaattgaggg cacggtgtcg   1080

agggtattgg gccgggagta caagctgccc atggacgacc tgctgccact tctcatctac   1140

gtggtgtcgc gcgcccgaat tcagcacctg ggagccgaga tccacctgat ccgtgacatg   1200

atggacccca accacacagg aggcctgtat gacttcctgc tcacagccct ggagtcctgt   1260

tacgagcaca tccagaaaga agacatgagg ctgcaccgct tacctggcca ctggcactcc   1320

agggagctct ggtagcctgg cctttcctgg acagactgaa gagctgagca gggcactgcc   1380

agcctgtccc tcattaccca aggcaagggg caggacaggc cctcagaagc agctcttgga   1440

ggagatgagc attttgtttt gcacaggaag atgctgctgc tgccctgact gggatgaggg   1500

tgaggggtga cgggtgtggc cctggatgtg gtggttttcc cttggccact agcccatctt   1560

caatgacccc ttaatctgca gcagctcaca ggctgggggt gaggagtccc tggcttctct   1620

tagcctgagc ctttctccca agttccagag cctctccggg cctcagtgct gccatctgta   1680

caatggtgga gtgagtacgc tgtaaaggac cttccattca ttttgctgaa ttccagagtc   1740

cttttggaaa actgacttta gtctgctggg ctgtattgac ctctggcagg ctcgaagcct   1800

cactgggtat gcagtcaaca ggatgggcct ggagatccgt gaactgcagg ccacgtaccc   1860

atgacgtaaa cggcggcact ggagcaagct ggggcggggg gtgggtaaac cctcactgcc   1920

agcaggcccc aagtggcttg taaatcattc tcctgtgatg tctgtgggcc tgcgtgggga   1980

caacaggggc acatgacatc tgcctgggcc ctgaccaata aaccctcaga cccaggaccc   2040

aggaccctgc tgtagttggg gagcaggagt acctttggga ggggaggact ttatttaaac   2100

agtggttcta gtgtgggacc aagagaggca ggagctgggt cttggggcag ctttattcct   2160

gttgggcctc agtttctctt ccccacacag tttatcttcc gtcacattgt gccgggtgac   2220

gtgcacggtc tccctctgcc ctagccggag atgcatgatg acaggcagtg tgatgtgttc   2280

tgaaagtgtc cagggcaaag cgtagggaga gggtggattt gtgcagggtg cagctctgga   2340

gaagaagctg gatcactctt ggtcccattc cctaggccct gagcaagtca ggctcctggc   2400

tctgggtgtg gctcccccaa acgaagtact gacttcagcc tgtgagggga gggttgaggg   2460

aggctctgga aagcccagcc acacctgagt ccctggcagt agccttgggg cagagggcac   2520

ccgcagagtc ccagagatga tgtgggcagt gggcagagag agccttggcg cctctgtttg   2580

ccaccacttc cccaggaagg agggacagca tttctctggc tggttccact aaatgtgcca   2640

gcccaaatgc agggcatggg ctctggttct gccaggagcc tgtgacaccc ccaggaaggg   2700

ggtggaactg aggaagagcg aggatatgca ggcactcatg cttaccggga ctggggcagc   2760

tcactaggat tctatccttt ccaatcggca tcagccagct cttgtcccct gataagtgag   2820

gacagcctga ccctggcctc aaatgcagcc atccctgagt tcatgcgatg ctgacgggac   2880

cccagcacac ttccctgcct cctttgagat ctgcgagccc ttgctgcagt tcagattcaa   2940

caaggccctc tgcccaccct ctcactaggc ctcacccaac accagtggaa ctggagcctc   3000

tggctgggca cagtggctca ctttgggagg ctgaggcagg aaggctgctg gaaactgaga   3060

gttcaagacc agcctgggca acatagtgag accctgtctc tacaaataca aaataaaata   3120

attagctggg tgtgttggtg tgtgcctgtg gtcccagcta ctcgggaggc tgaggtggga   3180

agatccctga gcctggaggg tcgaggttgc agtgagcgga gatcgcacct ctgcactcaa   3240

tcctgggtga caaaatgaaa ccctgcctca aaaataaaaa taaaaataaa aataaaataa   3300

ataaaaaaga gcatctgg                                                 3318


<210>  9214
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  9214

Met Glu Asp Ile Leu Glu Glu Leu Leu Gln His Arg Glu Pro Lys Ala 
1               5                   10                  15      


Leu Gln Leu Tyr Leu Arg Lys Ala Leu Ser Asn Ser Leu His Pro Leu 
            20                  25                  30          


Gly Lys Leu Leu Arg Thr Leu Met Leu Thr Phe Gln Ala Thr Tyr Ala 
        35                  40                  45              


Gly Val Gly Ala Asn Lys His Leu Gln Glu Leu Ala Gln Glu Glu Val 
    50                  55                  60                  


Lys Gln His Ala Gln Glu Leu Trp Ala Ala Tyr Arg Gly Leu Leu Arg 
65                  70                  75                  80  


Val Ala Leu Glu Arg Lys Gly Gln Ala Leu Glu Glu Asp Glu Asp Thr 
                85                  90                  95      


Glu Thr Arg Asp Leu Gln Val His Gly Leu Val Leu Pro Leu Met Leu 
            100                 105                 110         


Pro Ser Phe Tyr Ser Glu Leu Phe Thr Leu Tyr Leu Leu Leu His Glu 
        115                 120                 125             


Arg Glu Asp Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser Leu Phe 
    130                 135                 140                 


Pro Asp Thr Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His Leu Trp 
145                 150                 155                 160 


Pro Leu Lys Asp Leu Thr Leu Thr Ser Asn Gln Arg Tyr Ser Leu Val 
                165                 170                 175     


Arg Asp Lys Cys Phe Leu Ser Ala Thr Glu Cys Leu Gln Lys Ile Met 
            180                 185                 190         


Thr Thr Val Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg Thr Tyr 
        195                 200                 205             


Gly Glu Ile Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu Tyr Lys 
    210                 215                 220                 


Leu Pro Met Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val Ser Arg 
225                 230                 235                 240 


Ala Arg Ile Gln His Leu Gly Ala Glu Ile His Leu Ile Arg Asp Met 
                245                 250                 255     


Met Asp Pro Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu Thr Ala 
            260                 265                 270         


Leu Glu Ser Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg Leu His 
        275                 280                 285             


Arg Leu Pro Gly His Trp His Ser Arg Glu Leu Trp 
    290                 295                 300 


<210>  9215
<211>  617
<212>  DNA
<213>  Homosapiens

<400>  9215
atttgtgcag ggtgcagctc tggagaagaa gctggatcat catgcttacc gggactgggg     60

cagctcacta ggattctatc ctttccaatc ggcatcagcc agctcttgtc ccctgataag    120

tgaggacagc ctgaccctgg cctcaaatgc agccatccct gagttcatgc gatgctgacg    180

ggaccccagc acacttccct gcctcctttg agatctgcga gcccttgctg cagttcagat    240

tcaacaaggc cctctgccca ccctctcact aggcctcacc caacaccagt ggaactggag    300

cctctggctg ggcacagtgg ctcactttgg gaggctgagg caggaaggct gctggaaact    360

gagagttcaa gaccagcctg ggcaacatag tgagaccctg tctctacaaa tacaaaataa    420

aataattagc tgggtgtgtt ggtgtgtgcc tgtggtccca gctactcggg aggctgaggt    480

gggaagatcc ctgagcctgg agggtcgagg ttgcagtgag cggagatcgc acctctgcac    540

tcaatcctgg gtgacaaaat gaaaccctgc ctcaaaaata aaaataaaaa taaaaataaa    600

ataaataaaa aagagca                                                   617


<210>  9216
<211>  72
<212>  PRT
<213>  Homosapiens

<400>  9216

Met Leu Thr Gly Pro Gln His Thr Ser Leu Pro Pro Leu Arg Ser Ala 
1               5                   10                  15      


Ser Pro Cys Cys Ser Ser Asp Ser Thr Arg Pro Ser Ala His Pro Leu 
            20                  25                  30          


Thr Arg Pro His Pro Thr Pro Val Glu Leu Glu Pro Leu Ala Gly His 
        35                  40                  45              


Ser Gly Ser Leu Trp Glu Ala Glu Ala Gly Arg Leu Leu Glu Thr Glu 
    50                  55                  60                  


Ser Ser Arg Pro Ala Trp Ala Thr 
65                  70          


<210>  9217
<211>  2130
<212>  DNA
<213>  Homosapiens

<400>  9217
ggtcccagcc agggtgctgg ggtgctagag gtagagtgag gaccacaccc caggtgtcca     60

gccatccagg ccagcgctcc ttccccagct gcctgtccgc gacaggcctc ttctccttgt    120

ctccctcgct ctcttggtgg ggcggtgttc tccagaattc agcacctggg agccgagatc    180

cacctgatcc gtgacatgat ggaccccaac cacacaggag gcctgtatga cttcctgctc    240

acagccctgg agtcctgtta cgagcacatc cagaaagaag acatgaggct gcaccgctta    300

cctggccact ggcactccag ggagctctgg tagcctggcc tttcctggac agactgaaga    360

gctgagcagg gcactgccag cctgtccctc attacccaag gcaaggggca ggacaggccc    420

tcagaagcag ctcttggagg agatgagcat tttgttttgc acaggaagat gctgctgctg    480

ccctgactgg gatgagggtg aggggtgacg ggtgtggccc tggatgtggt ggttttccct    540

tggccactag cccatcttca atgacccctt aatctgcagc agctcacagg ctgggggtga    600

ggagtccctg gcttctctta gcctgagcct ttctcccaag ttccagagcc tctccgggcc    660

tcagtgctgc catctgtaca atggtggagt gagtacgctg taaaggacct tccattcatt    720

ttgctgaatt ccagagtcct tttggaaaac tgactttagt ctgctgggct gtattgacct    780

ctggcaggct cgaagcctca ctgggtatgc agtcaacagg atgggcctgg agatccgtga    840

actgcaggcc acgtacccat gacgtaaacg gcggcactgg agcaagctgg ggcggggggt    900

gggtaaaccc tcactgccag caggccccaa gtggcttgta aatcattctc ctgtgatgtc    960

tgtgggcctg cgtggggaca acaggggcac atgacatctg cctgggccct gaccaataaa   1020

ccctcagacc caggacccag gaccctgctg tagttgggga gcaggagtac ctttgggagg   1080

ggaggacttt atttaaacag tggttctagt gtgggaccaa gagaggcagg agctgggtct   1140

tggggcagct ttattcctgt tgggcctcag tttctcttcc ccacacagtt tatcttccgt   1200

cacattgtgc cgggtgacgt gcacggtctc cctctgccct agccggagat gcatgatgac   1260

aggcagtgtg atgtgttctg aaagtgtcca gggcaaagcg tagggagagg gtggatttgt   1320

gcagggtgca gctctggaga agaagctgga tcactcttgg tcccattccc taggccctga   1380

gcaagtcagg ctcctggctc tgggtgtggc tcccccaaac gaagtactga cttcagcctg   1440

tgaggggagg gttgagggag gctctggaaa gcccagccac acctgagtcc ctggcagtag   1500

ccttggggca gagggcaccc gcagagtccc agagatgatg tgggcagtgg gcagagagag   1560

ccttggcgcc tctgtttgcc accacttccc caggaaggag ggacagcatt tctctggctg   1620

gttccactaa atgtgccagc ccaaatgcag ggcatgggct ctggttctgc caggagcctg   1680

tgacaccccc aggaaggggg tggaactgag gaagagcgag gatatgcagg cactcatgct   1740

taccgggact ggggcagctc actaggattc tatcctttcc aatcggcatc agccagctct   1800

tgtcccctga taagtgagga cagcctgacc ctggcctcaa atgcagccat ccctgagttc   1860

atgcgatgct gacgggaccc cagcacactt ccctgcctcc tttgagatct gcgagccctt   1920

gctgcagttc agattcaaca aggccctctg cccaccctct cactaggcct cacccaacac   1980

cagtggaact ggagcctctg gctgggcaca gtggctcact ttgggaggct gaggcaggaa   2040

ggctgctgga aactgagagt tcaagaccag cctgggcaac atagtgagac cctgtctcta   2100

caaatacaaa ataaaataat tagctgggtg                                    2130


<210>  9218
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  9218

Met Met Asp Pro Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu Thr 
1               5                   10                  15      


Ala Leu Glu Ser Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg Leu 
            20                  25                  30          


His Arg Leu Pro Gly His Trp His Ser Arg Glu Leu Trp 
        35                  40                  45  


<210>  9219
<211>  2454
<212>  DNA
<213>  Homosapiens

<400>  9219
atcccagacc ccaccttgct catcccaacc tgttccggtc tccccatcag ggacctccag     60

gtgcatggat tggtgctgcc cctcatgctg cccagcttct actcagagct cttcacgctc    120

tacctgctgc ttcatgagcg ggaggacagc ttctacagcc agggcattgc caacttgagc    180

ctctttcctg atacccaact gctcgagttc ctggatgtgc agaagcactt gtggcccctc    240

aaggacctca cgctgacgag caatcagagg tactccctgg tcagggacaa gtgtttcctg    300

tcagccaccg agtgcctgca gaagatcatg accacggtgg acccacggga gaagctggag    360

gtgctggaga ggacatacgg ggaaattgag ggcacggtgt cgagggtatt gggccgggag    420

tacaagctgc ccatggacga cctgctgcca cttctcatct acgtggtgtc gcgcgcccga    480

attcagcacc tgggagccga gatccacctg atccgtgaca tgatggaccc caaccacaca    540

ggaggcctgt atgacttcct gctcacagcc ctggagtcct gttacgagca catccagaaa    600

gaagacatga ggctgcaccg cttacctggc cactggcact ccagggagct ctggtagcct    660

ggcctttcct ggacagactg aagagctgag cagggcactg ccagcctgtc cctcattacc    720

caaggcaagg ggcaggacag gccctcagaa gcagctcttg gaggagatga gcattttgtt    780

ttgcacagga agatgctgct gctgccctga ctgggatgag ggtgaggggt gacgggtgtg    840

gccctggatg tggtggtttt cccttggcca ctagcccatc ttcaatgacc ccttaatctg    900

cagcagctca caggctgggg gtgaggagtc cctggcttct cttagcctga gcctttctcc    960

caagttccag agcctctccg ggcctcagtg ctgccatctg tacaatggtg gagtgagtac   1020

gctgtaaagg accttccatt cattttgctg aattccagag tccttttgga aaactgactt   1080

tagtctgctg ggctgtattg acctctggca ggctcgaagc ctcactgggt atgcagtcaa   1140

caggatgggc ctggagatcc gtgaactgca ggccacgtac ccatgacgta aacggcggca   1200

ctggagcaag ctggggcggg gggtgggtaa accctcactg ccagcaggcc ccaagtggct   1260

tgtaaatcat tctcctgtga tgtctgtggg cctgcgtggg gacaacaggg gcacatgaca   1320

tctgcctggg ccctgaccaa taaaccctca gacccaggac ccaggaccct gctgtagttg   1380

gggagcagga gtacctttgg gaggggagga ctttatttaa acagtggttc tagtgtggga   1440

ccaagagagg caggagctgg gtcttggggc agctttattc ctgttgggcc tcagtttctc   1500

ttccccacac agtttatctt ccgtcacatt gtgccgggtg acgtgcacgg tctccctctg   1560

ccctagccgg agatgcatga tgacaggcag tgtgatgtgt tctgaaagtg tccagggcaa   1620

agcgtaggga gagggtggat ttgtgcaggg tgcagctctg gagaagaagc tggatcactc   1680

ttggtcccat tccctaggcc ctgagcaagt caggctcctg gctctgggtg tggctccccc   1740

aaacgaagta ctgacttcag cctgtgaggg gagggttgag ggaggctctg gaaagcccag   1800

ccacacctga gtccctggca gtagccttgg ggcagagggc acccgcagag tcccagagat   1860

gatgtgggca gtgggcagag agagccttgg cgcctctgtt tgccaccact tccccaggaa   1920

ggagggacag catttctctg gctggttcca ctaaatgtgc cagcccaaat gcagggcatg   1980

ggctctggtt ctgccaggag cctgtgacac ccccaggaag ggggtggaac tgaggaagag   2040

cgaggatatg caggcactca tgcttaccgg gactggggca gctcactagg attctatcct   2100

ttccaatcgg catcagccag ctcttgtccc ctgataagtg aggacagcct gaccctggcc   2160

tcaaatgcag ccatccctga gttcatgcga tgctgacggg accccagcac acttccctgc   2220

ctcctttgag atctgcgagc ccttgctgca gttcagattc aacaaggccc tctgcccacc   2280

ctctcactag gcctcaccca acaccagtgg aactggagcc tctggctggg cacagtggct   2340

cactttggga ggctgaggca ggaaggctgc tggaaactga gagttcaaga ccagcctggg   2400

caacatagtg agaccctgtc tctacaaata caaaataaaa taattagctg ggtg         2454


<210>  9220
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  9220

Met Leu Pro Ser Phe Tyr Ser Glu Leu Phe Thr Leu Tyr Leu Leu Leu 
1               5                   10                  15      


His Glu Arg Glu Asp Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser 
            20                  25                  30          


Leu Phe Pro Asp Thr Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His 
        35                  40                  45              


Leu Trp Pro Leu Lys Asp Leu Thr Leu Thr Ser Asn Gln Arg Tyr Ser 
    50                  55                  60                  


Leu Val Arg Asp Lys Cys Phe Leu Ser Ala Thr Glu Cys Leu Gln Lys 
65                  70                  75                  80  


Ile Met Thr Thr Val Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg 
                85                  90                  95      


Thr Tyr Gly Glu Ile Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu 
            100                 105                 110         


Tyr Lys Leu Pro Met Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val 
        115                 120                 125             


Ser Arg Ala Arg Ile Gln His Leu Gly Ala Glu Ile His Leu Ile Arg 
    130                 135                 140                 


Asp Met Met Asp Pro Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu 
145                 150                 155                 160 


Thr Ala Leu Glu Ser Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg 
                165                 170                 175     


Leu His Arg Leu Pro Gly His Trp His Ser Arg Glu Leu Trp 
            180                 185                 190 


<210>  9221
<211>  3132
<212>  DNA
<213>  Homosapiens

<400>  9221
aggaaggaac cagctgtaag ggagggcaga gggggatgtc ttggagggga atcccagact     60

ttggacactg gtctctcttg gaccaagacc ccctctctgg cttggcctcc agatctgccc    120

acctttctgt ctccgtcttt ccaggattcc atatgcttct gtctgtcttc tcgtcgcagg    180

gtagattctc tgtccctttc tctgctgctc ttcctcctgg agccgtggag gcagctgggc    240

gtgggtgcct tccccgtgga aagccgctgg cagggagtct acagcccctt ccgggacttt    300

gtgtgtgctg gctgccccag ggacctgcag gaggccctgc tgggcttcga cgtgcagagc    360

tccagggagc tgcgtaggtc tcaggattac ctgtcctgcg agaggaccca ccctgaggac    420

agtgtgggca gtatggaaga catcctggag gagctgctgc agcaccggga gcccaaggcc    480

ctgcagctgt acctcaggaa ggctctgagc aactcactgc accccctggg aaagctgctc    540

cggacactga tgctgacctt ccaggctacc tacgcaggtg tcggggccaa caagcacctg    600

caggagctgg cccaggagga ggtgaagcag catgcccagg aactctgggc tgcctacagg    660

ggtctgctgc gagttgcctt agagcgcaag ggccaggccc tggaggagga tgaagacaca    720

gagacaaggg acctccaggt gcatggattg gtgctgcccc tcatgctgcc cagcttctac    780

tcagagctct tcacgctcta cctgctgctt catgagcggg aggacagctt ctacagccag    840

ggcattgcca acttgagcct ctttcctgat acccaactgc tcgagttcct ggatgtgcag    900

aagcacttgt ggcccctcaa ggacctcacg ctgacgagca atcagaggta ctccctggtc    960

agggacaagt gtttcctgtc agccaccgag tgcctgcaga agatcatgac cacggtggac   1020

ccacgggaga agctggaggt gctggagagg acatacgggg aaattgaggg cacggtgtcg   1080

agggtattgg gccgggagta caagctgccc atggacgacc tgctgccact tctcatctac   1140

gtggtgtcgc gcgcccgaat tcagcacctg ggagccgaga tccacctgat ccgtgacatg   1200

atggacccca accacacagg aggcctgtat gacttcctgc tcacagccct ggagtcctgt   1260

tacgagcaca tccagaaaga agacatgagg ctgcaccgct tacctggcca ctggcactcc   1320

agggagctct ggtagcctgg cctttcctgg acagactgaa gagctgagca gggcactgcc   1380

agcctgtccc tcattaccca aggcaagggg caggacaggc cctcagaagc agctcttgga   1440

ggagatgagc attttgtttt gcacaggaag atgctgctgc tgccctgact gggatgaggg   1500

tgaggggtga cgggtgtggc cctggatgtg gtggttttcc cttggccact agcccatctt   1560

caatgacccc ttaatctgca gcagctcaca ggctgggggt gaggagtccc tggcttctct   1620

tagcctgagc ctttctccca agttccagag cctctccggg cctcagtgct gccatctgta   1680

caatggtgga gtgagtacgc tgtaaaggac cttccattca ttttgctgaa ttccagagtc   1740

cttttggaaa actgacttta gtctgctggg ctgtattgac ctctggcagg ctcgaagcct   1800

cactgggtat gcagtcaaca ggatgggcct ggagatccgt gaactgcagg ccacgtaccc   1860

atgacgtaaa cggcggcact ggagcaagct ggggcggggg gtgggtaaac cctcactgcc   1920

agcaggcccc aagtggcttg taaatcattc tcctgtgatg tctgtgggcc tgcgtgggga   1980

caacaggggc acatgacatc tgcctgggcc ctgaccaata aaccctcaga cccaggaccc   2040

aggaccctgc tgtagttggg gagcaggagt acctttggga ggggaggact ttatttaaac   2100

agtggttcta gtgtgggacc aagagaggca ggagctgggt cttggggcag ctttattcct   2160

gttgggcctc agtttctctt ccccacacag tttatcttcc gtcacattgt gccgggtgac   2220

gtgcacggtc tccctctgcc ctagccggag atgcatgatg acaggcagtg tgatgtgttc   2280

tgaaagtgtc cagggcaaag cgtagggaga gggtggattt gtgcagggtg cagctctgga   2340

gaagaagctg gatcactctt ggtcccattc cctaggccct gagcaagtca ggctcctggc   2400

tctgggtgtg gctcccccaa acgaagtact gacttcagcc tgtgagggga gggttgaggg   2460

aggctctgga aagcccagcc acacctgagt ccctggcagt agccttgggg cagagggcac   2520

ccgcagagtc ccagagatga tgtgggcagt gggcagagag agccttggcg cctctgtttg   2580

ccaccacttc cccaggaagg agggacagca tttctctggc tggttccact aaatgtgcca   2640

gcccaaatgc agggcatggg ctctggttct gccaggagcc tgtgacaccc ccaggaaggg   2700

ggtggaactg aggaagagcg aggatatgca ggcactcatg cttaccggga ctggggcagc   2760

tcactaggat tctatccttt ccaatcggca tcagccagct cttgtcccct gataagtgag   2820

gacagcctga ccctggcctc aaatgcagcc atccctgagt tcatgcgatg ctgacgggac   2880

cccagcacac ttccctgcct cctttgagat ctgcgagccc ttgctgcagt tcagattcaa   2940

caaggccctc tgcccaccct ctcactaggc ctcacccaac accagtggaa ctggagcctc   3000

tggctgggca cagtggctca ctttgggagg ctgaggcagg aaggctgctg gaaactgaga   3060

gttcaagacc agcctgggca acatagtgag accctgtctc tacaaataca aaataaaata   3120

attagctggg tg                                                       3132


<210>  9222
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  9222

Met Glu Asp Ile Leu Glu Glu Leu Leu Gln His Arg Glu Pro Lys Ala 
1               5                   10                  15      


Leu Gln Leu Tyr Leu Arg Lys Ala Leu Ser Asn Ser Leu His Pro Leu 
            20                  25                  30          


Gly Lys Leu Leu Arg Thr Leu Met Leu Thr Phe Gln Ala Thr Tyr Ala 
        35                  40                  45              


Gly Val Gly Ala Asn Lys His Leu Gln Glu Leu Ala Gln Glu Glu Val 
    50                  55                  60                  


Lys Gln His Ala Gln Glu Leu Trp Ala Ala Tyr Arg Gly Leu Leu Arg 
65                  70                  75                  80  


Val Ala Leu Glu Arg Lys Gly Gln Ala Leu Glu Glu Asp Glu Asp Thr 
                85                  90                  95      


Glu Thr Arg Asp Leu Gln Val His Gly Leu Val Leu Pro Leu Met Leu 
            100                 105                 110         


Pro Ser Phe Tyr Ser Glu Leu Phe Thr Leu Tyr Leu Leu Leu His Glu 
        115                 120                 125             


Arg Glu Asp Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser Leu Phe 
    130                 135                 140                 


Pro Asp Thr Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His Leu Trp 
145                 150                 155                 160 


Pro Leu Lys Asp Leu Thr Leu Thr Ser Asn Gln Arg Tyr Ser Leu Val 
                165                 170                 175     


Arg Asp Lys Cys Phe Leu Ser Ala Thr Glu Cys Leu Gln Lys Ile Met 
            180                 185                 190         


Thr Thr Val Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg Thr Tyr 
        195                 200                 205             


Gly Glu Ile Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu Tyr Lys 
    210                 215                 220                 


Leu Pro Met Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val Ser Arg 
225                 230                 235                 240 


Ala Arg Ile Gln His Leu Gly Ala Glu Ile His Leu Ile Arg Asp Met 
                245                 250                 255     


Met Asp Pro Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu Thr Ala 
            260                 265                 270         


Leu Glu Ser Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg Leu His 
        275                 280                 285             


Arg Leu Pro Gly His Trp His Ser Arg Glu Leu Trp 
    290                 295                 300 


<210>  9223
<211>  4728
<212>  DNA
<213>  Homosapiens

<400>  9223
gagccgcaca ggcagtcccg gcgcggggca accacagcgc tcaggaggcc ctgagtccgg     60

cacctggcca tgtgcaaccc tgaggaggca gctctgctgc ggctggagga ggtcttctca    120

gccaccctcg cccatgtcaa cagccttgtc ctccagcccc tgctcccagc cgccccagat    180

ccctcggatc cctggggcag agagtgcctg cggctcttgc aacagctgca caagagctcc    240

cagcaactct gggaggtgac ggaggaaagc ctgcactcac tgcaggagag gctgcgttac    300

ccggactcca ccggtctgga gtccctgctg ctgctgcgag gtgctgaccg tgtactgcag    360

gcccacatag agtacattga gtcctacaca agctgcatgg tggtgcaggc cttccagaag    420

gcagcaaaga ggagaagcga gtactggcgg ggccagcgga aggcgctgcg gcagctgctt    480

tcaggtgtga gctcagaggg ctcggtgggc gcatcgctgg gccaggccct ccaccagcca    540

ctcgcccatc acgtgcaaca gtacgtgctc ctcctgctga gcctcgggga caccattggg    600

gagcatcacc caacccggga gctggtggtg aacgcagtca ccctctttgg gaacctgcag    660

tccttcatga agcaggagtt ggaccaggct gtggccacac aggctctctg gcacaccctg    720

agaggccggc tgagggatgt gctctgcacc cctgctcaca gactccttca ggacagccag    780

gacgtacccg tgacggtcgc accgttgcgg gctgagcgtg tgctgctctt tgatgatgcc    840

ctcgtcctgc tgcagggcca caatgtccac acctttgatc tgaagctggt gtgggtggat    900

cctgggcagg acgggtgcac gtttcacctc ctcacgcccg aagaagagtt ctccttttgt    960

gccaaggact cccagggcca ggcagtctgg cagtggaagg tgacctgggc tgttcaccag   1020

gccctgcatg ggaagaagga cttccccgtg ctgggggctg gcctggagcc ctcccagcct   1080

cccgactgcc gctgcgcaga atataccttc caggcagagg gccggctctg ccaggccacc   1140

tacgagggcg agtggtgcag gggccggccc cacggcaagg gaaccctgaa atggccggat   1200

gggcggaatc acgtggggaa tttctgccag ggcctggagc atggcttcgg catccgcctg   1260

ctgccccagg cctctgagga caagttcgac tgttacaagt gtcactggcg agaaggcagc   1320

atgtgtggct acggcatctg tgagtacagc accgacgagg tgtacaaggg ctacttccag   1380

gagggcctgc ggcacggatt tggggtcctt gagagtggtc cgcaggcccc ccagcccttc   1440

aggtacacgg gccactggga gaggggccag aggagcggct atggcattga ggaggatggt   1500

gacagaggtg agcgctacat tggcatgtgg caggctggtc agcgccacgg cccaggggtc   1560

atggtcaccc aggcaggtgt ctgctaccag ggcaccttcc aggcggacaa gacggtgggc   1620

ccgggcatcc tcctctctga agacgactcc ctgtatgagg gcaccttcac cagggacctg   1680

accctcatgg ggaagggcaa ggtcaccttc cccaatggct tcaccctgga gggctcgttc   1740

ggcagtgggg cagggagagg actgcacaca cagggtgtgc tggacacggc tgccctccca   1800

ccagacccga gcagtacctg caagaggcag ctgggcgtgg gtgccttccc cgtggaaagc   1860

cgctggcagg gagtctacag ccccttccgg gactttgtgt gtgctggctg ccccagggac   1920

ctgcaggagg ccctgctggg cttcgacgtg cagagctcca gggagctgcg taggtctcag   1980

gattacctgt cctgcgagag gacccaccct gaggacagtg tgggcagtat ggaagacatc   2040

ctggaggagc tgctgcagca ccgggagccc aaggccctgc agctgtacct caggaaggct   2100

ctgagcaact cactgcaccc cctgggaaag ctgctccgga cactgatgct gaccttccag   2160

gctacctacg caggtgtcgg ggccaacaag cacctgcagg agctggccca ggaggaggtg   2220

aagcagcatg cccaggaact ctgggctgcc tacaggggtc tgctgcgagt tgccttagag   2280

cgcaagggcc aggccctgga ggaggatgaa gacacagaga caagggacct ccaggtgcat   2340

ggattggtgc tgcccctcat gctgcccagc ttctactcag agctcttcac gctctacctg   2400

ctgcttcatg agcgggagga cagcttctac agccagggca ttgccaactt gagcctcttt   2460

cctgataccc aactgctcga gttcctggat gtgcagaagc acttgtggcc cctcaaggac   2520

ctcacgctga cgagcaatca gaggtactcc ctggtcaggg acaagtgttt cctgtcagcc   2580

accgagtgcc tgcagaagat catgaccacg gtggacccac gggagaagct ggaggtgctg   2640

gagaggacat acggggaaat tgagggcacg gtgtcgaggg tattgggccg ggagtacaag   2700

ctgcccatgg acgacctgct gccacttctc atctacgtgg tgtcgcgcgc ccgaattcag   2760

cacctgggag ccgagatcca cctgatccgt gacatgatgg accccaacca cacaggaggc   2820

ctgtatgact tcctgctcac agccctggag tcctgttacg agcacatcca gaaagaagac   2880

atgaggctgc accgcttacc tggccactgg cactccaggg agctctggta gcctggcctt   2940

tcctggacag actgaagagc tgagcagggc actgccagcc tgtccctcat tacccaaggc   3000

aaggggcagg acaggccctc agaagcagct cttggaggag atgagcattt tgttttgcac   3060

aggaagatgc tgctgctgcc ctgactggga tgagggtgag gggtgacggg tgtggccctg   3120

gatgtggtgg ttttcccttg gccactagcc catcttcaat gaccccttaa tctgcagcag   3180

ctcacaggct gggggtgagg agtccctggc ttctcttagc ctgagccttt ctcccaagtt   3240

ccagagcctc tccgggcctc agtgctgcca tctgtacaat ggtggagtga gtacgctgta   3300

aaggaccttc cattcatttt gctgaattcc agagtccttt tggaaaactg actttagtct   3360

gctgggctgt attgacctct ggcaggctcg aagcctcact gggtatgcag tcaacaggat   3420

gggcctggag atccgtgaac tgcaggccac gtacccatga cgtaaacggc ggcactggag   3480

caagctgggg cggggggtgg gtaaaccctc actgccagca ggccccaagt ggcttgtaaa   3540

tcattctcct gtgatgtctg tgggcctgcg tggggacaac aggggcacat gacatctgcc   3600

tgggccctga ccaataaacc ctcagaccca ggacccagga ccctgctgta gttggggagc   3660

aggagtacct ttgggagggg aggactttat ttaaacagtg gttctagtgt gggaccaaga   3720

gaggcaggag ctgggtcttg gggcagcttt attcctgttg ggcctcagtt tctcttcccc   3780

acacagttta tcttccgtca cattgtgccg ggtgacgtgc acggtctccc tctgccctag   3840

ccggagatgc atgatgacag gcagtgtgat gtgttctgaa agtgtccagg gcaaagcgta   3900

gggagagggt ggatttgtgc agggtgcagc tctggagaag aagctggatc actcttggtc   3960

ccattcccta ggccctgagc aagtcaggct cctggctctg ggtgtggctc ccccaaacga   4020

agtactgact tcagcctgtg aggggagggt tgagggaggc tctggaaagc ccagccacac   4080

ctgagtccct ggcagtagcc ttggggcaga gggcacccgc agagtcccag agatgatgtg   4140

ggcagtgggc agagagagcc ttggcgcctc tgtttgccac cacttcccca ggaaggaggg   4200

acagcatttc tctggctggt tccactaaat gtgccagccc aaatgcaggg catgggctct   4260

ggttctgcca ggagcctgtg acacccccag gaagggggtg gaactgagga agagcgagga   4320

tatgcaggca ctcatgctta ccgggactgg ggcagctcac taggattcta tcctttccaa   4380

tcggcatcag ccagctcttg tcccctgata agtgaggaca gcctgaccct ggcctcaaat   4440

gcagccatcc ctgagttcat gcgatgctga cgggacccca gcacacttcc ctgcctcctt   4500

tgagatctgc gagcccttgc tgcagttcag attcaacaag gccctctgcc caccctctca   4560

ctaggcctca cccaacacca gtggaactgg agcctctggc tgggcacagt ggctcacttt   4620

gggaggctga ggcaggaagg ctgctggaaa ctgagagttc aagaccagcc tgggcaacat   4680

agtgagaccc tgtctctaca aatacaaaat aaaataatta gctgggtg                4728


<210>  9224
<211>  953
<212>  PRT
<213>  Homosapiens

<400>  9224

Met Cys Asn Pro Glu Glu Ala Ala Leu Leu Arg Leu Glu Glu Val Phe 
1               5                   10                  15      


Ser Ala Thr Leu Ala His Val Asn Ser Leu Val Leu Gln Pro Leu Leu 
            20                  25                  30          


Pro Ala Ala Pro Asp Pro Ser Asp Pro Trp Gly Arg Glu Cys Leu Arg 
        35                  40                  45              


Leu Leu Gln Gln Leu His Lys Ser Ser Gln Gln Leu Trp Glu Val Thr 
    50                  55                  60                  


Glu Glu Ser Leu His Ser Leu Gln Glu Arg Leu Arg Tyr Pro Asp Ser 
65                  70                  75                  80  


Thr Gly Leu Glu Ser Leu Leu Leu Leu Arg Gly Ala Asp Arg Val Leu 
                85                  90                  95      


Gln Ala His Ile Glu Tyr Ile Glu Ser Tyr Thr Ser Cys Met Val Val 
            100                 105                 110         


Gln Ala Phe Gln Lys Ala Ala Lys Arg Arg Ser Glu Tyr Trp Arg Gly 
        115                 120                 125             


Gln Arg Lys Ala Leu Arg Gln Leu Leu Ser Gly Val Ser Ser Glu Gly 
    130                 135                 140                 


Ser Val Gly Ala Ser Leu Gly Gln Ala Leu His Gln Pro Leu Ala His 
145                 150                 155                 160 


His Val Gln Gln Tyr Val Leu Leu Leu Leu Ser Leu Gly Asp Thr Ile 
                165                 170                 175     


Gly Glu His His Pro Thr Arg Glu Leu Val Val Asn Ala Val Thr Leu 
            180                 185                 190         


Phe Gly Asn Leu Gln Ser Phe Met Lys Gln Glu Leu Asp Gln Ala Val 
        195                 200                 205             


Ala Thr Gln Ala Leu Trp His Thr Leu Arg Gly Arg Leu Arg Asp Val 
    210                 215                 220                 


Leu Cys Thr Pro Ala His Arg Leu Leu Gln Asp Ser Gln Asp Val Pro 
225                 230                 235                 240 


Val Thr Val Ala Pro Leu Arg Ala Glu Arg Val Leu Leu Phe Asp Asp 
                245                 250                 255     


Ala Leu Val Leu Leu Gln Gly His Asn Val His Thr Phe Asp Leu Lys 
            260                 265                 270         


Leu Val Trp Val Asp Pro Gly Gln Asp Gly Cys Thr Phe His Leu Leu 
        275                 280                 285             


Thr Pro Glu Glu Glu Phe Ser Phe Cys Ala Lys Asp Ser Gln Gly Gln 
    290                 295                 300                 


Ala Val Trp Gln Trp Lys Val Thr Trp Ala Val His Gln Ala Leu His 
305                 310                 315                 320 


Gly Lys Lys Asp Phe Pro Val Leu Gly Ala Gly Leu Glu Pro Ser Gln 
                325                 330                 335     


Pro Pro Asp Cys Arg Cys Ala Glu Tyr Thr Phe Gln Ala Glu Gly Arg 
            340                 345                 350         


Leu Cys Gln Ala Thr Tyr Glu Gly Glu Trp Cys Arg Gly Arg Pro His 
        355                 360                 365             


Gly Lys Gly Thr Leu Lys Trp Pro Asp Gly Arg Asn His Val Gly Asn 
    370                 375                 380                 


Phe Cys Gln Gly Leu Glu His Gly Phe Gly Ile Arg Leu Leu Pro Gln 
385                 390                 395                 400 


Ala Ser Glu Asp Lys Phe Asp Cys Tyr Lys Cys His Trp Arg Glu Gly 
                405                 410                 415     


Ser Met Cys Gly Tyr Gly Ile Cys Glu Tyr Ser Thr Asp Glu Val Tyr 
            420                 425                 430         


Lys Gly Tyr Phe Gln Glu Gly Leu Arg His Gly Phe Gly Val Leu Glu 
        435                 440                 445             


Ser Gly Pro Gln Ala Pro Gln Pro Phe Arg Tyr Thr Gly His Trp Glu 
    450                 455                 460                 


Arg Gly Gln Arg Ser Gly Tyr Gly Ile Glu Glu Asp Gly Asp Arg Gly 
465                 470                 475                 480 


Glu Arg Tyr Ile Gly Met Trp Gln Ala Gly Gln Arg His Gly Pro Gly 
                485                 490                 495     


Val Met Val Thr Gln Ala Gly Val Cys Tyr Gln Gly Thr Phe Gln Ala 
            500                 505                 510         


Asp Lys Thr Val Gly Pro Gly Ile Leu Leu Ser Glu Asp Asp Ser Leu 
        515                 520                 525             


Tyr Glu Gly Thr Phe Thr Arg Asp Leu Thr Leu Met Gly Lys Gly Lys 
    530                 535                 540                 


Val Thr Phe Pro Asn Gly Phe Thr Leu Glu Gly Ser Phe Gly Ser Gly 
545                 550                 555                 560 


Ala Gly Arg Gly Leu His Thr Gln Gly Val Leu Asp Thr Ala Ala Leu 
                565                 570                 575     


Pro Pro Asp Pro Ser Ser Thr Cys Lys Arg Gln Leu Gly Val Gly Ala 
            580                 585                 590         


Phe Pro Val Glu Ser Arg Trp Gln Gly Val Tyr Ser Pro Phe Arg Asp 
        595                 600                 605             


Phe Val Cys Ala Gly Cys Pro Arg Asp Leu Gln Glu Ala Leu Leu Gly 
    610                 615                 620                 


Phe Asp Val Gln Ser Ser Arg Glu Leu Arg Arg Ser Gln Asp Tyr Leu 
625                 630                 635                 640 


Ser Cys Glu Arg Thr His Pro Glu Asp Ser Val Gly Ser Met Glu Asp 
                645                 650                 655     


Ile Leu Glu Glu Leu Leu Gln His Arg Glu Pro Lys Ala Leu Gln Leu 
            660                 665                 670         


Tyr Leu Arg Lys Ala Leu Ser Asn Ser Leu His Pro Leu Gly Lys Leu 
        675                 680                 685             


Leu Arg Thr Leu Met Leu Thr Phe Gln Ala Thr Tyr Ala Gly Val Gly 
    690                 695                 700                 


Ala Asn Lys His Leu Gln Glu Leu Ala Gln Glu Glu Val Lys Gln His 
705                 710                 715                 720 


Ala Gln Glu Leu Trp Ala Ala Tyr Arg Gly Leu Leu Arg Val Ala Leu 
                725                 730                 735     


Glu Arg Lys Gly Gln Ala Leu Glu Glu Asp Glu Asp Thr Glu Thr Arg 
            740                 745                 750         


Asp Leu Gln Val His Gly Leu Val Leu Pro Leu Met Leu Pro Ser Phe 
        755                 760                 765             


Tyr Ser Glu Leu Phe Thr Leu Tyr Leu Leu Leu His Glu Arg Glu Asp 
    770                 775                 780                 


Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser Leu Phe Pro Asp Thr 
785                 790                 795                 800 


Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His Leu Trp Pro Leu Lys 
                805                 810                 815     


Asp Leu Thr Leu Thr Ser Asn Gln Arg Tyr Ser Leu Val Arg Asp Lys 
            820                 825                 830         


Cys Phe Leu Ser Ala Thr Glu Cys Leu Gln Lys Ile Met Thr Thr Val 
        835                 840                 845             


Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg Thr Tyr Gly Glu Ile 
    850                 855                 860                 


Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu Tyr Lys Leu Pro Met 
865                 870                 875                 880 


Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val Ser Arg Ala Arg Ile 
                885                 890                 895     


Gln His Leu Gly Ala Glu Ile His Leu Ile Arg Asp Met Met Asp Pro 
            900                 905                 910         


Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu Thr Ala Leu Glu Ser 
        915                 920                 925             


Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg Leu His Arg Leu Pro 
    930                 935                 940                 


Gly His Trp His Ser Arg Glu Leu Trp 
945                 950             


<210>  9225
<211>  6164
<212>  DNA
<213>  Homosapiens

<400>  9225
gagccgcaca ggcagtcccg gcgcggggca accacagcgc tcaggaggcc ctgagtccgg     60

cacctggcca tgtgcaaccc tgaggaggca gctctgctgc ggctggagga ggtcttctca    120

gccaccctcg cccatgtcaa cagccttgtc ctccagcccc tgctcccagc cgccccagat    180

ccctcggatc cctggggcag agagtgcctg cggctcttgc aacagctgca caagagctcc    240

cagcaactct gggaggtgac ggaggaaagc ctgcactcac tgcaggagag gctgcgttac    300

ccggactcca ccggtctgga gtccctgctg ctgctgcgag gtgctgaccg tgtactgcag    360

gcccacatag agtacattga gtcctacaca agctgcatgg tggtgcaggc cttccagaag    420

gcagcaaaga ggagaagcga gtactggcgg ggccagcgga aggcgctgcg gcagctgctt    480

tcaggtgtga gctcagaggg ctcggtgggc gcatcgctgg gccaggccct ccaccagcca    540

ctcgcccatc acgtgcaaca gtacgtgctc ctcctgctga gcctcgggga caccattggg    600

gagcatcacc caacccggga gctggtggtg aacgcagtca ccctctttgg gaacctgcag    660

tccttcatga agcaggagtt ggaccaggct gtggccacac aggctctctg gcacaccctg    720

agaggccggc tgagggatgt gctctgcacc cctgctcaca gactccttca ggacagccag    780

gacgtacccg tgacggtcgc accgttgcgg gctgagcgtg tgctgctctt tgatgatgcc    840

ctcgtcctgc tgcagggcca caatgtccac acctttgatc tgaagctggt gtgggtggat    900

cctgggcagg acgggtgcac gtttcacctc ctcacgcccg aagaagagtt ctccttttgt    960

gccaaggact cccagggcca ggcagtctgg cagtggaagg tgacctgggc tgttcaccag   1020

gccctgcatg ggaagaagga cttccccgtg ctgggggctg gcctggagcc ctcccagcct   1080

cccgactgcc gctgcgcaga atataccttc caggcagagg gccggctctg ccaggccacc   1140

tacgagggcg agtggtgcag gggccggccc cacggcaagg gaaccctgaa atggccggat   1200

gggcggaatc acgtggggaa tttctgccag ggcctggagc atggcttcgg catccgcctg   1260

ctgccccagg cctctgagga caagttcgac tgttacaagt gtcactggcg agaaggcagc   1320

atgtgtggct acggcatctg tgagtacagc accgacgagg tgtacaaggg ctacttccag   1380

gagggcctgc ggcacggatt tggggtcctt gagagtggtc cgcaggcccc ccagcccttc   1440

aggtacacgg gccactggga gaggggccag aggagcggct atggcattga ggaggatggt   1500

gacagaggtg agcgctacat tggcatgtgg caggctggtc agcgccacgg cccaggggtc   1560

atggtcaccc aggcaggtgt ctgctaccag ggcaccttcc aggcggacaa gacggtgggc   1620

ccgggcatcc tcctctctga agacgactcc ctgtatgagg gcaccttcac cagggacctg   1680

accctcatgg ggaagggcaa ggtcaccttc cccaatggct tcaccctgga gggctcgttc   1740

ggcagtgggg cagggagagg actgcacaca cagggtgtgc tggacacggc tgccctccca   1800

ccagacccga gcagtacctg caagaggcag ctgggcgtgg gtgccttccc cgtggaaagc   1860

cgctggcagg gagtctacag ccccttccgg gactttgtgt gtgctggctg ccccagggac   1920

ctgcaggagg ccctgctggg cttcgacgtg cagagctcca gggagctgcg taggtctcag   1980

gattacctgt cctgcgagag gacccaccct gaggacagtg tgggcagtat ggaagacatc   2040

ctggaggagc tgctgcagca ccgggagccc aaggccctgc agctgtacct caggaaggct   2100

ctgagcaact cactgcaccc cctgggaaag ctgctccgga cactgatgct gaccttccag   2160

gctacctacg caggtgtcgg ggccaacaag cacctgcagg agctggccca ggaggaggtg   2220

aagcagcatg cccaggaact ctgggctgcc tacaggtggg ctcggtggca aacgggacag   2280

ctactgccct gtgacactag tgtgcccttt ccaggcatca gttctgcctt gcatttggga   2340

ggaatgccaa gtgtctgatt caacaatgaa ccagaggctt ggtcagtgtg cagctgctga   2400

gcaaaagggt tagagggtgg ggaggtgaga gcaaaggccc agctgcagcc ctcagctaga   2460

gtccaagacc caaccaggcg ctgggctgac tctgaccgca ggtgcactct caccccactg   2520

taggctgagc ttggccctgg actcggaaca cacctgcagt cccaggctgg gctgtgaccc   2580

catgaaacac tgcaaataga agccttagat gctatagttc cttctgctgc tggattctca   2640

ggctaacatc ctggagctcc aaccttctaa cttctgtggt ttgagaggat gaaccctgca   2700

ggccatgtcc acagttctga gaggccacct gcttttgcct ttgttgactg gtggtagaac   2760

tccagttctg tggcaagggg cagccacacc atttctctct cattgactca caggggtctg   2820

ctgcgagttg ccttagagcg caagggccag gccctggagg aggatgaaga cacagagaca   2880

aggtgactgg cgcaggtctc cttggggcct gccgtgtcca gggaggcctc atgcgtctgc   2940

tcctaggacc tcccttgggg aaagaggtgc ttctggggaa gtgctgggca ttcactctat   3000

tgaccaaaca ttgtgcattg atcgtttgtg gattagaatg acccatgacc tctgttctgt   3060

gaggaaccag ggagggggca ctgctacaat gcattgaatg catctttgtt ctaaatgtat   3120

gatcccaatc tcatctttcg catgcagaag gtgagtagct ccccgaggca ccctcctctc   3180

cctgcacaca gatggggaaa ccgagggctg gtagggatga gcctgaggtt atacaggagt   3240

taggtgggca tgaaatttgt ttcccccagt ccctggagca aaccttacaa tttgccttta   3300

gattctagac ctgaaagtgt tcctgatcag agaggccttc ctgtcactgc cttgcaggag   3360

gcaagggaaa tggggttaga cattagggag gattccccgc ccggagtcct agcacagcaa   3420

accaggaggt ggaactgaat cagcctggaa tggctgctga gagctcagct gcaagttgct   3480

ggtccatctg gggccctggt tttgctttca gtcaaatggg gatccaactc ctgccccacc   3540

tgccatcttg gttgtcaaag tcaaaggagg gaatgaagtt atgaattgaa ttgggcaaat   3600

gatgactgag aacaggcttg gaaaaggttt tctggggagg aggaggctgg aggccaggac   3660

actgtttgtt gtggaactag gagctctttg agacgagact ccaagtagta atcccagacc   3720

ccaccttgct catcccaacc tgttccggtc tccccatcag ggacctccag gtgcatggat   3780

tggtgctgcc cctcatgctg cccagcttct actcagagct cttcacgctc tacctgctgc   3840

ttcatgagcg ggaggacagc ttctacagcc agggcattgc caacttgagc ctctttcctg   3900

atacccaact gctcgagttc ctggatgtgc agaagcactt gtggcccctc aaggacctca   3960

cgctgacgag caatcagagg tactccctgg tcagggacaa gtgtttcctg tcagccaccg   4020

agtgcctgca gaagatcatg accacggtgg acccacggga gaagctggag gtgctggaga   4080

ggacatacgg ggaaattgag ggcacggtgt cgagggtatt gggccgggag tacaagctgc   4140

ccatggacga cctgctgcca cttctcatct acgtggtgtc gcgcgcccga attcagcacc   4200

tgggagccga gatccacctg atccgtgaca tgatggaccc caaccacaca ggaggcctgt   4260

atgacttcct gctcacagcc ctggagtcct gttacgagca catccagaaa gaagacatga   4320

ggctgcaccg cttacctggc cactggcact ccagggagct ctggtagcct ggcctttcct   4380

ggacagactg aagagctgag cagggcactg ccagcctgtc cctcattacc caaggcaagg   4440

ggcaggacag gccctcagaa gcagctcttg gaggagatga gcattttgtt ttgcacagga   4500

agatgctgct gctgccctga ctgggatgag ggtgaggggt gacgggtgtg gccctggatg   4560

tggtggtttt cccttggcca ctagcccatc ttcaatgacc ccttaatctg cagcagctca   4620

caggctgggg gtgaggagtc cctggcttct cttagcctga gcctttctcc caagttccag   4680

agcctctccg ggcctcagtg ctgccatctg tacaatggtg gagtgagtac gctgtaaagg   4740

accttccatt cattttgctg aattccagag tccttttgga aaactgactt tagtctgctg   4800

ggctgtattg acctctggca ggctcgaagc ctcactgggt atgcagtcaa caggatgggc   4860

ctggagatcc gtgaactgca ggccacgtac ccatgacgta aacggcggca ctggagcaag   4920

ctggggcggg gggtgggtaa accctcactg ccagcaggcc ccaagtggct tgtaaatcat   4980

tctcctgtga tgtctgtggg cctgcgtggg gacaacaggg gcacatgaca tctgcctggg   5040

ccctgaccaa taaaccctca gacccaggac ccaggaccct gctgtagttg gggagcagga   5100

gtacctttgg gaggggagga ctttatttaa acagtggttc tagtgtggga ccaagagagg   5160

caggagctgg gtcttggggc agctttattc ctgttgggcc tcagtttctc ttccccacac   5220

agtttatctt ccgtcacatt gtgccgggtg acgtgcacgg tctccctctg ccctagccgg   5280

agatgcatga tgacaggcag tgtgatgtgt tctgaaagtg tccagggcaa agcgtaggga   5340

gagggtggat ttgtgcaggg tgcagctctg gagaagaagc tggatcactc ttggtcccat   5400

tccctaggcc ctgagcaagt caggctcctg gctctgggtg tggctccccc aaacgaagta   5460

ctgacttcag cctgtgaggg gagggttgag ggaggctctg gaaagcccag ccacacctga   5520

gtccctggca gtagccttgg ggcagagggc acccgcagag tcccagagat gatgtgggca   5580

gtgggcagag agagccttgg cgcctctgtt tgccaccact tccccaggaa ggagggacag   5640

catttctctg gctggttcca ctaaatgtgc cagcccaaat gcagggcatg ggctctggtt   5700

ctgccaggag cctgtgacac ccccaggaag ggggtggaac tgaggaagag cgaggatatg   5760

caggcactca tgcttaccgg gactggggca gctcactagg attctatcct ttccaatcgg   5820

catcagccag ctcttgtccc ctgataagtg aggacagcct gaccctggcc tcaaatgcag   5880

ccatccctga gttcatgcga tgctgacggg accccagcac acttccctgc ctcctttgag   5940

atctgcgagc ccttgctgca gttcagattc aacaaggccc tctgcccacc ctctcactag   6000

gcctcaccca acaccagtgg aactggagcc tctggctggg cacagtggct cactttggga   6060

ggctgaggca ggaaggctgc tggaaactga gagttcaaga ccagcctggg caacatagtg   6120

agaccctgtc tctacaaata caaaataaaa taattagctg ggtg                    6164


<210>  9226
<211>  762
<212>  PRT
<213>  Homosapiens

<400>  9226

Met Cys Asn Pro Glu Glu Ala Ala Leu Leu Arg Leu Glu Glu Val Phe 
1               5                   10                  15      


Ser Ala Thr Leu Ala His Val Asn Ser Leu Val Leu Gln Pro Leu Leu 
            20                  25                  30          


Pro Ala Ala Pro Asp Pro Ser Asp Pro Trp Gly Arg Glu Cys Leu Arg 
        35                  40                  45              


Leu Leu Gln Gln Leu His Lys Ser Ser Gln Gln Leu Trp Glu Val Thr 
    50                  55                  60                  


Glu Glu Ser Leu His Ser Leu Gln Glu Arg Leu Arg Tyr Pro Asp Ser 
65                  70                  75                  80  


Thr Gly Leu Glu Ser Leu Leu Leu Leu Arg Gly Ala Asp Arg Val Leu 
                85                  90                  95      


Gln Ala His Ile Glu Tyr Ile Glu Ser Tyr Thr Ser Cys Met Val Val 
            100                 105                 110         


Gln Ala Phe Gln Lys Ala Ala Lys Arg Arg Ser Glu Tyr Trp Arg Gly 
        115                 120                 125             


Gln Arg Lys Ala Leu Arg Gln Leu Leu Ser Gly Val Ser Ser Glu Gly 
    130                 135                 140                 


Ser Val Gly Ala Ser Leu Gly Gln Ala Leu His Gln Pro Leu Ala His 
145                 150                 155                 160 


His Val Gln Gln Tyr Val Leu Leu Leu Leu Ser Leu Gly Asp Thr Ile 
                165                 170                 175     


Gly Glu His His Pro Thr Arg Glu Leu Val Val Asn Ala Val Thr Leu 
            180                 185                 190         


Phe Gly Asn Leu Gln Ser Phe Met Lys Gln Glu Leu Asp Gln Ala Val 
        195                 200                 205             


Ala Thr Gln Ala Leu Trp His Thr Leu Arg Gly Arg Leu Arg Asp Val 
    210                 215                 220                 


Leu Cys Thr Pro Ala His Arg Leu Leu Gln Asp Ser Gln Asp Val Pro 
225                 230                 235                 240 


Val Thr Val Ala Pro Leu Arg Ala Glu Arg Val Leu Leu Phe Asp Asp 
                245                 250                 255     


Ala Leu Val Leu Leu Gln Gly His Asn Val His Thr Phe Asp Leu Lys 
            260                 265                 270         


Leu Val Trp Val Asp Pro Gly Gln Asp Gly Cys Thr Phe His Leu Leu 
        275                 280                 285             


Thr Pro Glu Glu Glu Phe Ser Phe Cys Ala Lys Asp Ser Gln Gly Gln 
    290                 295                 300                 


Ala Val Trp Gln Trp Lys Val Thr Trp Ala Val His Gln Ala Leu His 
305                 310                 315                 320 


Gly Lys Lys Asp Phe Pro Val Leu Gly Ala Gly Leu Glu Pro Ser Gln 
                325                 330                 335     


Pro Pro Asp Cys Arg Cys Ala Glu Tyr Thr Phe Gln Ala Glu Gly Arg 
            340                 345                 350         


Leu Cys Gln Ala Thr Tyr Glu Gly Glu Trp Cys Arg Gly Arg Pro His 
        355                 360                 365             


Gly Lys Gly Thr Leu Lys Trp Pro Asp Gly Arg Asn His Val Gly Asn 
    370                 375                 380                 


Phe Cys Gln Gly Leu Glu His Gly Phe Gly Ile Arg Leu Leu Pro Gln 
385                 390                 395                 400 


Ala Ser Glu Asp Lys Phe Asp Cys Tyr Lys Cys His Trp Arg Glu Gly 
                405                 410                 415     


Ser Met Cys Gly Tyr Gly Ile Cys Glu Tyr Ser Thr Asp Glu Val Tyr 
            420                 425                 430         


Lys Gly Tyr Phe Gln Glu Gly Leu Arg His Gly Phe Gly Val Leu Glu 
        435                 440                 445             


Ser Gly Pro Gln Ala Pro Gln Pro Phe Arg Tyr Thr Gly His Trp Glu 
    450                 455                 460                 


Arg Gly Gln Arg Ser Gly Tyr Gly Ile Glu Glu Asp Gly Asp Arg Gly 
465                 470                 475                 480 


Glu Arg Tyr Ile Gly Met Trp Gln Ala Gly Gln Arg His Gly Pro Gly 
                485                 490                 495     


Val Met Val Thr Gln Ala Gly Val Cys Tyr Gln Gly Thr Phe Gln Ala 
            500                 505                 510         


Asp Lys Thr Val Gly Pro Gly Ile Leu Leu Ser Glu Asp Asp Ser Leu 
        515                 520                 525             


Tyr Glu Gly Thr Phe Thr Arg Asp Leu Thr Leu Met Gly Lys Gly Lys 
    530                 535                 540                 


Val Thr Phe Pro Asn Gly Phe Thr Leu Glu Gly Ser Phe Gly Ser Gly 
545                 550                 555                 560 


Ala Gly Arg Gly Leu His Thr Gln Gly Val Leu Asp Thr Ala Ala Leu 
                565                 570                 575     


Pro Pro Asp Pro Ser Ser Thr Cys Lys Arg Gln Leu Gly Val Gly Ala 
            580                 585                 590         


Phe Pro Val Glu Ser Arg Trp Gln Gly Val Tyr Ser Pro Phe Arg Asp 
        595                 600                 605             


Phe Val Cys Ala Gly Cys Pro Arg Asp Leu Gln Glu Ala Leu Leu Gly 
    610                 615                 620                 


Phe Asp Val Gln Ser Ser Arg Glu Leu Arg Arg Ser Gln Asp Tyr Leu 
625                 630                 635                 640 


Ser Cys Glu Arg Thr His Pro Glu Asp Ser Val Gly Ser Met Glu Asp 
                645                 650                 655     


Ile Leu Glu Glu Leu Leu Gln His Arg Glu Pro Lys Ala Leu Gln Leu 
            660                 665                 670         


Tyr Leu Arg Lys Ala Leu Ser Asn Ser Leu His Pro Leu Gly Lys Leu 
        675                 680                 685             


Leu Arg Thr Leu Met Leu Thr Phe Gln Ala Thr Tyr Ala Gly Val Gly 
    690                 695                 700                 


Ala Asn Lys His Leu Gln Glu Leu Ala Gln Glu Glu Val Lys Gln His 
705                 710                 715                 720 


Ala Gln Glu Leu Trp Ala Ala Tyr Arg Trp Ala Arg Trp Gln Thr Gly 
                725                 730                 735     


Gln Leu Leu Pro Cys Asp Thr Ser Val Pro Phe Pro Gly Ile Ser Ser 
            740                 745                 750         


Ala Leu His Leu Gly Gly Met Pro Ser Val 
        755                 760         


<210>  9227
<211>  2676
<212>  DNA
<213>  Homosapiens

<400>  9227
ggacctccag gtgcatggat tggtgctgcc cctcatgctg cccagcttct actcagagct     60

cttcacgctc tacctgctgc ttcatgagcg ggaggacagc ttctacagcc agggcattgc    120

caacttgagc ctctttcctg atacccaact gctcgagttc ctggatgtgc agaagtaagc    180

cttcccttcc cccgtgccgt gttagccagg actcaaactc gactcagact gtcttcagcc    240

aaaaggtggg gctggggttg ataggttcat gtacccacca agttctaagc ttatgcattc    300

aggtgtggct ggatctaggt gttcaactga atgacagagg gaagcacctt ccatttctgt    360

tggtctttct cagcctcccc cttgtggtga caaacaccat aagcaccaac cgctcaaggt    420

tcataccctc ccagctcctc tcccagagtc cccacaggag ctggcattgc cttccaacag    480

ctccctcaga gcccctgaag tccctcactg gctcggcttg gggcttgggt cttgagccca    540

cccctgagtg ccagccgtga ttgaccaggc ctgcctgaat atccactgct gaggctgggg    600

caagatcacc tgctctgagc acttgggctg agagtagggg agaggaggtc cctcagggga    660

gactgaggac tgctctgggt gcatgtcggg aggtgtttac cacaccccag ggcctccctt    720

ccaccctcag tctccaaaat gtcctttctc ttcagtgtcc catctatcca ttgatgccac    780

aagtgacccc actgtccaca gtagagggca cgggcactgt ctctgctccc acatccaggt    840

ctcctttgtt acacagggat ggtgcttccc acccaccctg caaatccctg tttcttcctc    900

tatcttggtg actgtgtcct gcatctgacc agccaccagc ctaaagacct ggctgccagt    960

gcttcccaag catgccccgc ctccctcacc acctcagtgt cgcttcccca caccagcctc   1020

cacctctgct gcatgagggc tgcatccccc tgctcacagc cctgtgctgg ctcagcagag   1080

cctcctggat ggagtgcagt ctcctcaccc ctccctctct actggtcacc acgacctggc   1140

tcatacaagc ccctgggccg cccttacctc cctggagctt ctggagctct gccttctcca   1200

ggaatccttc catcctcccc atgacctagg ctgatctcct tccccttttc aggacccaga   1260

tctgccgggg gaaacagtgg catagggaat ttgccctctg acctcagact ctgccccttg   1320

tcgaggcaga gcctcctgtc tcactttttc aatttcaggc acttgtggcc cctcaaggac   1380

ctcacgctga cgagcaatca gaggtactcc ctggtcaggg acaagtgttt cctgtcagcc   1440

accgagtgcc tgcagaagat catgaccacg gtggacccac gggagaagct ggaggtgctg   1500

gagaggacat acggggaaat tgagggcacg gtgtcgaggg tattgggccg ggagtacaag   1560

ctgcccatgg acgacctgct gccacttctc atctacgtgg tgtcgcgcgc ccgatgggga   1620

agccaaggcc cagaaaaggg agggtcccag ccagggtgct ggggtgctag aggtagagtg   1680

aggaccacac cccaggtgtc cagccatcca ggccagcgct ccttccccag ctgcctgtcc   1740

gcgacaggcc tcttctcctt gtctccctcg ctctcttggt ggggcggtgt tctccagaat   1800

tcagcacctg ggagccgaga tccacctgat ccgtgacatg atggacccca accacacagg   1860

aggcctgtat gacttcctgc tcacagccct ggagtcctgt tacgagcaca tccagaaaga   1920

agacatgagg ctgcaccgct tacctggcca ctggcactcc agggagctct ggtagcctgg   1980

cctttcctgg acagactgaa gagctgagca gggcactgcc agcctgtccc tcattaccca   2040

aggcaagggg caggacaggc cctcagaagc agctcttgga ggagatgagc attttgtttt   2100

gcacaggaag atgctgctgc tgccctgact gggatgaggg tgaggggtga cgggtgtggc   2160

cctggatgtg gtggttttcc cttggccact agcccatctt caatgacccc ttaatctgca   2220

gcagctcaca ggctgggggt gaggagtccc tggcttctct tagcctgagc ctttctccca   2280

agttccagag cctctccggg cctcagtgct gccatctgta caatggtgga gtgagtacgc   2340

tgtaaaggac cttccattca ttttgctgaa ttccagagtc cttttggaaa actgacttta   2400

gtctgctggg ctgtattgac ctctggcagg ctcgaagcct cactgggtat gcagtcaaca   2460

ggatgggcct ggagatccgt gaactgcagg ccacgtaccc atgacgtaaa cggcggcact   2520

ggagcaagct ggggcggggg gtgggtaaac cctcactgcc agcaggcccc aagtggcttg   2580

taaatcattc tcctgtgatg tctgtgggcc tgcgtgggga caacaggggc acatgacatc   2640

tgcctgggcc ctgaccaata aaccctcaga cccagg                             2676


<210>  9228
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  9228

Met Thr Thr Val Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg Thr 
1               5                   10                  15      


Tyr Gly Glu Ile Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu Tyr 
            20                  25                  30          


Lys Leu Pro Met Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val Ser 
        35                  40                  45              


Arg Ala Arg Trp Gly Ser Gln Gly Pro Glu Lys Gly Gly Ser Gln Pro 
    50                  55                  60                  


Gly Cys Trp Gly Ala Arg Gly Arg Val Arg Thr Thr Pro Gln Val Ser 
65                  70                  75                  80  


Ser His Pro Gly Gln Arg Ser Phe Pro Ser Cys Leu Ser Ala Thr Gly 
                85                  90                  95      


Leu Phe Ser Leu Ser Pro Ser Leu Ser Trp Trp Gly Gly Val Leu Gln 
            100                 105                 110         


Asn Ser Ala Pro Gly Ser Arg Asp Pro Pro Asp Pro 
        115                 120                 


<210>  9229
<211>  1358
<212>  DNA
<213>  Homosapiens

<400>  9229
atcccagacc ccaccttgct catcccaacc tgttccggtc tccccatcag ggacctccag     60

gtgcatggat tggtgctgcc cctcatgctg cccagcttct actcagagct cttcacgctc    120

tacctgctgc ttcatgagcg ggaggacagc ttctacagcc agggcattgc caacttgagc    180

ctctttcctg atacccaact gctcgagttc ctggatgtgc agaagcactt gtggcccctc    240

aaggacctca cgctgacgag caatcagagg tactccctgg tcagggacaa gtgtttcctg    300

tcagccaccg agtgcctgca gaagatcatg accacggtgg acccacggga gaagctggag    360

gtgctggaga ggacatacgg ggaaattgag ggcacggtgt cgagggtatt gggccgggag    420

tacaagctgc ccatggacga cctgctgcca cttctcatct acgtggtgtc gcgcgcccga    480

attcagcacc tgggagccga gatccacctg atccgtgaca tgatggaccc caaccacaca    540

ggaggcctgt atgacttcct gctcacagcc ctggagtcct gttacgagca catccagaaa    600

gaagacatga ggctgcaccg cttacctggc cactggcact ccagggagct ctggtagcct    660

ggcctttcct ggacagactg aagagctgag cagggcactg ccagcctgtc cctcattacc    720

caaggcaagg ggcaggacag gccctcagaa gcagctcttg gaggagatga gcattttgtt    780

ttgcacagga agatgctgct gctgccctga ctgggatgag ggtgaggggt gacgggtgtg    840

gccctggatg tggtggtttt cccttggcca ctagcccatc ttcaatgacc ccttaatctg    900

cagcagctca caggctgggg gtgaggagtc cctggcttct cttagcctga gcctttctcc    960

caagttccag agcctctccg ggcctcagtg ctgccatctg tacaatggtg gagtgagtac   1020

gctgtaaagg accttccatt cattttgctg aattccagag tccttttgga aaactgactt   1080

tagtctgctg ggctgtattg acctctggca ggctcgaagc ctcactgggt atgcagtcaa   1140

caggatgggc ctggagatcc gtgaactgca ggccacgtac ccatgacgta aacggcggca   1200

ctggagcaag ctggggcggg gggtgggtaa accctcactg ccagcaggcc ccaagtggct   1260

tgtaaatcat tctcctgtga tgtctgtggg cctgcgtggg gacaacaggg gcacatgaca   1320

tctgcctggg ccctgaccaa taaaccctca gacccagg                           1358


<210>  9230
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  9230

Met Leu Pro Ser Phe Tyr Ser Glu Leu Phe Thr Leu Tyr Leu Leu Leu 
1               5                   10                  15      


His Glu Arg Glu Asp Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser 
            20                  25                  30          


Leu Phe Pro Asp Thr Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His 
        35                  40                  45              


Leu Trp Pro Leu Lys Asp Leu Thr Leu Thr Ser Asn Gln Arg Tyr Ser 
    50                  55                  60                  


Leu Val Arg Asp Lys Cys Phe Leu Ser Ala Thr Glu Cys Leu Gln Lys 
65                  70                  75                  80  


Ile Met Thr Thr Val Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg 
                85                  90                  95      


Thr Tyr Gly Glu Ile Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu 
            100                 105                 110         


Tyr Lys Leu Pro Met Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val 
        115                 120                 125             


Ser Arg Ala Arg Ile Gln His Leu Gly Ala Glu Ile His Leu Ile Arg 
    130                 135                 140                 


Asp Met Met Asp Pro Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu 
145                 150                 155                 160 


Thr Ala Leu Glu Ser Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg 
                165                 170                 175     


Leu His Arg Leu Pro Gly His Trp His Ser Arg Glu Leu Trp 
            180                 185                 190 


<210>  9231
<211>  2036
<212>  DNA
<213>  Homosapiens

<400>  9231
aggaaggaac cagctgtaag ggagggcaga gggggatgtc ttggagggga atcccagact     60

ttggacactg gtctctcttg gaccaagacc ccctctctgg cttggcctcc agatctgccc    120

acctttctgt ctccgtcttt ccaggattcc atatgcttct gtctgtcttc tcgtcgcagg    180

gtagattctc tgtccctttc tctgctgctc ttcctcctgg agccgtggag gcagctgggc    240

gtgggtgcct tccccgtgga aagccgctgg cagggagtct acagcccctt ccgggacttt    300

gtgtgtgctg gctgccccag ggacctgcag gaggccctgc tgggcttcga cgtgcagagc    360

tccagggagc tgcgtaggtc tcaggattac ctgtcctgcg agaggaccca ccctgaggac    420

agtgtgggca gtatggaaga catcctggag gagctgctgc agcaccggga gcccaaggcc    480

ctgcagctgt acctcaggaa ggctctgagc aactcactgc accccctggg aaagctgctc    540

cggacactga tgctgacctt ccaggctacc tacgcaggtg tcggggccaa caagcacctg    600

caggagctgg cccaggagga ggtgaagcag catgcccagg aactctgggc tgcctacagg    660

ggtctgctgc gagttgcctt agagcgcaag ggccaggccc tggaggagga tgaagacaca    720

gagacaaggg acctccaggt gcatggattg gtgctgcccc tcatgctgcc cagcttctac    780

tcagagctct tcacgctcta cctgctgctt catgagcggg aggacagctt ctacagccag    840

ggcattgcca acttgagcct ctttcctgat acccaactgc tcgagttcct ggatgtgcag    900

aagcacttgt ggcccctcaa ggacctcacg ctgacgagca atcagaggta ctccctggtc    960

agggacaagt gtttcctgtc agccaccgag tgcctgcaga agatcatgac cacggtggac   1020

ccacgggaga agctggaggt gctggagagg acatacgggg aaattgaggg cacggtgtcg   1080

agggtattgg gccgggagta caagctgccc atggacgacc tgctgccact tctcatctac   1140

gtggtgtcgc gcgcccgaat tcagcacctg ggagccgaga tccacctgat ccgtgacatg   1200

atggacccca accacacagg aggcctgtat gacttcctgc tcacagccct ggagtcctgt   1260

tacgagcaca tccagaaaga agacatgagg ctgcaccgct tacctggcca ctggcactcc   1320

agggagctct ggtagcctgg cctttcctgg acagactgaa gagctgagca gggcactgcc   1380

agcctgtccc tcattaccca aggcaagggg caggacaggc cctcagaagc agctcttgga   1440

ggagatgagc attttgtttt gcacaggaag atgctgctgc tgccctgact gggatgaggg   1500

tgaggggtga cgggtgtggc cctggatgtg gtggttttcc cttggccact agcccatctt   1560

caatgacccc ttaatctgca gcagctcaca ggctgggggt gaggagtccc tggcttctct   1620

tagcctgagc ctttctccca agttccagag cctctccggg cctcagtgct gccatctgta   1680

caatggtgga gtgagtacgc tgtaaaggac cttccattca ttttgctgaa ttccagagtc   1740

cttttggaaa actgacttta gtctgctggg ctgtattgac ctctggcagg ctcgaagcct   1800

cactgggtat gcagtcaaca ggatgggcct ggagatccgt gaactgcagg ccacgtaccc   1860

atgacgtaaa cggcggcact ggagcaagct ggggcggggg gtgggtaaac cctcactgcc   1920

agcaggcccc aagtggcttg taaatcattc tcctgtgatg tctgtgggcc tgcgtgggga   1980

caacaggggc acatgacatc tgcctgggcc ctgaccaata aaccctcaga cccagg       2036


<210>  9232
<211>  300
<212>  PRT
<213>  Homosapiens

<400>  9232

Met Glu Asp Ile Leu Glu Glu Leu Leu Gln His Arg Glu Pro Lys Ala 
1               5                   10                  15      


Leu Gln Leu Tyr Leu Arg Lys Ala Leu Ser Asn Ser Leu His Pro Leu 
            20                  25                  30          


Gly Lys Leu Leu Arg Thr Leu Met Leu Thr Phe Gln Ala Thr Tyr Ala 
        35                  40                  45              


Gly Val Gly Ala Asn Lys His Leu Gln Glu Leu Ala Gln Glu Glu Val 
    50                  55                  60                  


Lys Gln His Ala Gln Glu Leu Trp Ala Ala Tyr Arg Gly Leu Leu Arg 
65                  70                  75                  80  


Val Ala Leu Glu Arg Lys Gly Gln Ala Leu Glu Glu Asp Glu Asp Thr 
                85                  90                  95      


Glu Thr Arg Asp Leu Gln Val His Gly Leu Val Leu Pro Leu Met Leu 
            100                 105                 110         


Pro Ser Phe Tyr Ser Glu Leu Phe Thr Leu Tyr Leu Leu Leu His Glu 
        115                 120                 125             


Arg Glu Asp Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser Leu Phe 
    130                 135                 140                 


Pro Asp Thr Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His Leu Trp 
145                 150                 155                 160 


Pro Leu Lys Asp Leu Thr Leu Thr Ser Asn Gln Arg Tyr Ser Leu Val 
                165                 170                 175     


Arg Asp Lys Cys Phe Leu Ser Ala Thr Glu Cys Leu Gln Lys Ile Met 
            180                 185                 190         


Thr Thr Val Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg Thr Tyr 
        195                 200                 205             


Gly Glu Ile Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu Tyr Lys 
    210                 215                 220                 


Leu Pro Met Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val Ser Arg 
225                 230                 235                 240 


Ala Arg Ile Gln His Leu Gly Ala Glu Ile His Leu Ile Arg Asp Met 
                245                 250                 255     


Met Asp Pro Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu Thr Ala 
            260                 265                 270         


Leu Glu Ser Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg Leu His 
        275                 280                 285             


Arg Leu Pro Gly His Trp His Ser Arg Glu Leu Trp 
    290                 295                 300 


<210>  9233
<211>  3940
<212>  DNA
<213>  Homosapiens

<400>  9233
ggtgggggtg cgagcgagga gccgcacagg cagtcccggc gcggggcaac cacagcgctc     60

aggaggccct gagtccggca cctggccatg tgcaaccctg aggaggcagc tctgctgcgg    120

ctggaggagg tcttctcagc caccctcgcc catgtcaaca gccttgtcct ccagcccctg    180

ctcccagccg ccccagatcc ctcggatccc tggggcagag agtgcctgcg gctcttgcaa    240

cagctgcaca agagctccca gcaactctgg gaggtgacgg aggaaagcct gcactcactg    300

caggagaggc tgcgttaccc ggactccacc ggtctggagt ccctgctgct gctgcgaggt    360

gctgaccgtg tactgcaggc ccacatagag tacattgagt cctacacaag ctgcatggtg    420

gtgcaggcct tccagaaggc agcaaagagg agaagcgagt actggcgggg ccagcggaag    480

gcgctgcggc agctgctttc aggtgtgagc tcagagggct cggtgggcgc atcgctgggc    540

caggccctcc accagccact cgcccatcac gtgcaacagt acgtgctcct cctgctgagc    600

ctcggggaca ccattgggga gcatcaccca acccgggagc tggtggtgaa cgcagtcacc    660

ctctttggga acctgcagtc cttcatgaag caggagttgg accaggctgt ggccacacag    720

gctctctggc acaccctgag aggccggctg agggatgtgc tctgcacccc tgctcacaga    780

ctccttcagg acagccagga cgtacccgtg acggtcgcac cgttgcgggc tgagcgtgtg    840

ctgctctttg atgatgccct cgtcctgctg cagggccaca atgtccacac ctttgatctg    900

aagctggtgt gggtggatcc tgggcaggac gggtgcacgt ttcacctcct cacgcccgaa    960

gaagagttct ccttttgtgc caaggactcc cagggccagg cagtctggca gtggaaggtg   1020

acctgggctg ttcaccaggc cctgcatggg aagaaggact tccccgtgct gggggctggc   1080

ctggagccct cccagcctcc cgactgccgc tgcgcagaat ataccttcca ggcagagggc   1140

cggctctgcc aggccaccta cgagggcgag tggtgcaggg gccggcccca cggcaaggga   1200

accctgaaat ggccggatgg gcggaatcac gtggggaatt tctgccaggg cctggagcat   1260

ggcttcggca tccgcctgct gccccaggcc tctgaggaca agttcgactg ttacaagtgt   1320

cactggcgag aaggcagcat gtgtggctac ggcatctgtg agtacagcac cgacgaggtg   1380

tacaagggct acttccagga gggcctgcgg cacggatttg gggtccttga gagtggtccg   1440

caggcccccc agcccttcag gtacacgggc cactgggaga ggggccagag gagcggctat   1500

ggcattgagg aggatggtga cagaggtgag cgctacattg gcatgtggca ggctggtcag   1560

cgccacggcc caggggtcat ggtcacccag gcaggtgtct gctaccaggg caccttccag   1620

gcggacaaga cggtgggccc gggcatcctc ctctctgaag acgactccct gtatgagggc   1680

accttcacca gggacctgac cctcatgggg aagggcaagg tcaccttccc caatggcttc   1740

accctggagg gctcgttcgg cagtggggca gggagaggac tgcacacaca gggtgtgctg   1800

gacacggctg ccctcccacc agacccgagc agtacctgca agaggcagct gggcgtgggt   1860

gccttccccg tggaaagccg ctggcaggga gtctacagcc ccttccggga ctttgtgtgt   1920

gctggctgcc ccagggacct gcaggaggcc ctgctgggct tcgacgtgca gagctccagg   1980

gagctgcgta ggtctcagga ttacctgtcc tgcgagagga cccaccctga ggacagtgtg   2040

ggcagtatgg aagacatcct ggaggagctg ctgcagcacc gggagcccaa ggccctgcag   2100

ctgtacctca ggaaggctct gagcaactca ctgcaccccc tgggaaagct gctccggaca   2160

ctgatgctga ccttccaggc tacctacgca ggtgtcgggg ccaacaagca cctgcaggag   2220

ctggcccagg aggaggtgaa gcagcatgcc caggaactct gggctgccta caggctgagc   2280

ttggccctgg actcggaaca cacctgcagt cccaggctgg gctgtgaccc catgaaacac   2340

tgcaaataga agccttagat gctatagttc cttctgctgc tggattctca ggctaacatc   2400

ctggagctcc aaccttctaa cttctgtggt ttgagaggat gaaccctgca ggccatgtcc   2460

acagttctga gaggccacct gcttttgcct ttgttgactg gtggtagaac tccagttctg   2520

tggcaagggg cagccacacc atttctctct cattgactca caggggtctg ctgcgagttg   2580

ccttagagcg caagggccag gccctggagg aggatgaaga cacagagaca agggacctcc   2640

aggtgcatgg attggtgctg cccctcatgc tgcccagctt ctactcagag ctcttcacgc   2700

tctacctgct gcttcatgag cgggaggaca gcttctacag ccagggcatt gccaacttga   2760

gcctctttcc tgatacccaa ctgctcgagt tcctggatgt gcagaagcac ttgtggcccc   2820

tcaaggacct cacgctgacg agcaatcaga ggtactccct ggtcagggac aagtgtttcc   2880

tgtcagccac cgagtgcctg cagaagatca tgaccacggt ggacccacgg gagaagctgg   2940

aggtgctgga gaggacatac ggggaaattg agggcacggt gtcgagggta ttgggccggg   3000

agtacaagct gcccatggac gacctgctgc cacttctcat ctacgtggtg tcgcgcgccc   3060

gaattcagca cctgggagcc gagatccacc tgatccgtga catgatggac cccaaccaca   3120

caggaggcct gtatgacttc ctgctcacag ccctggagtc ctgttacgag cacatccaga   3180

aagaagacat gaggctgcac cgcttacctg gccactggca ctccagggag ctctggtagc   3240

ctggcctttc ctggacagac tgaagagctg agcagggcac tgccagcctg tccctcatta   3300

cccaaggcaa ggggcaggac aggccctcag aagcagctct tggaggagat gagcattttg   3360

ttttgcacag gaagatgctg ctgctgccct gactgggatg agggtgaggg gtgacgggtg   3420

tggccctgga tgtggtggtt ttcccttggc cactagccca tcttcaatga ccccttaatc   3480

tgcagcagct cacaggctgg gggtgaggag tccctggctt ctcttagcct gagcctttct   3540

cccaagttcc agagcctctc cgggcctcag tgctgccatc tgtacaatgg tggagtgagt   3600

acgctgtaaa ggaccttcca ttcattttgc tgaattccag agtccttttg gaaaactgac   3660

tttagtctgc tgggctgtat tgacctctgg caggctcgaa gcctcactgg gtatgcagtc   3720

aacaggatgg gcctggagat ccgtgaactg caggccacgt acccatgacg taaacggcgg   3780

cactggagca agctggggcg gggggtgggt aaaccctcac tgccagcagg ccccaagtgg   3840

cttgtaaatc attctcctgt gatgtctgtg ggcctgcgtg gggacaacag gggcacatga   3900

catctgcctg ggccctgacc aataaaccct cagacccagg                         3940


<210>  9234
<211>  753
<212>  PRT
<213>  Homosapiens

<400>  9234

Met Cys Asn Pro Glu Glu Ala Ala Leu Leu Arg Leu Glu Glu Val Phe 
1               5                   10                  15      


Ser Ala Thr Leu Ala His Val Asn Ser Leu Val Leu Gln Pro Leu Leu 
            20                  25                  30          


Pro Ala Ala Pro Asp Pro Ser Asp Pro Trp Gly Arg Glu Cys Leu Arg 
        35                  40                  45              


Leu Leu Gln Gln Leu His Lys Ser Ser Gln Gln Leu Trp Glu Val Thr 
    50                  55                  60                  


Glu Glu Ser Leu His Ser Leu Gln Glu Arg Leu Arg Tyr Pro Asp Ser 
65                  70                  75                  80  


Thr Gly Leu Glu Ser Leu Leu Leu Leu Arg Gly Ala Asp Arg Val Leu 
                85                  90                  95      


Gln Ala His Ile Glu Tyr Ile Glu Ser Tyr Thr Ser Cys Met Val Val 
            100                 105                 110         


Gln Ala Phe Gln Lys Ala Ala Lys Arg Arg Ser Glu Tyr Trp Arg Gly 
        115                 120                 125             


Gln Arg Lys Ala Leu Arg Gln Leu Leu Ser Gly Val Ser Ser Glu Gly 
    130                 135                 140                 


Ser Val Gly Ala Ser Leu Gly Gln Ala Leu His Gln Pro Leu Ala His 
145                 150                 155                 160 


His Val Gln Gln Tyr Val Leu Leu Leu Leu Ser Leu Gly Asp Thr Ile 
                165                 170                 175     


Gly Glu His His Pro Thr Arg Glu Leu Val Val Asn Ala Val Thr Leu 
            180                 185                 190         


Phe Gly Asn Leu Gln Ser Phe Met Lys Gln Glu Leu Asp Gln Ala Val 
        195                 200                 205             


Ala Thr Gln Ala Leu Trp His Thr Leu Arg Gly Arg Leu Arg Asp Val 
    210                 215                 220                 


Leu Cys Thr Pro Ala His Arg Leu Leu Gln Asp Ser Gln Asp Val Pro 
225                 230                 235                 240 


Val Thr Val Ala Pro Leu Arg Ala Glu Arg Val Leu Leu Phe Asp Asp 
                245                 250                 255     


Ala Leu Val Leu Leu Gln Gly His Asn Val His Thr Phe Asp Leu Lys 
            260                 265                 270         


Leu Val Trp Val Asp Pro Gly Gln Asp Gly Cys Thr Phe His Leu Leu 
        275                 280                 285             


Thr Pro Glu Glu Glu Phe Ser Phe Cys Ala Lys Asp Ser Gln Gly Gln 
    290                 295                 300                 


Ala Val Trp Gln Trp Lys Val Thr Trp Ala Val His Gln Ala Leu His 
305                 310                 315                 320 


Gly Lys Lys Asp Phe Pro Val Leu Gly Ala Gly Leu Glu Pro Ser Gln 
                325                 330                 335     


Pro Pro Asp Cys Arg Cys Ala Glu Tyr Thr Phe Gln Ala Glu Gly Arg 
            340                 345                 350         


Leu Cys Gln Ala Thr Tyr Glu Gly Glu Trp Cys Arg Gly Arg Pro His 
        355                 360                 365             


Gly Lys Gly Thr Leu Lys Trp Pro Asp Gly Arg Asn His Val Gly Asn 
    370                 375                 380                 


Phe Cys Gln Gly Leu Glu His Gly Phe Gly Ile Arg Leu Leu Pro Gln 
385                 390                 395                 400 


Ala Ser Glu Asp Lys Phe Asp Cys Tyr Lys Cys His Trp Arg Glu Gly 
                405                 410                 415     


Ser Met Cys Gly Tyr Gly Ile Cys Glu Tyr Ser Thr Asp Glu Val Tyr 
            420                 425                 430         


Lys Gly Tyr Phe Gln Glu Gly Leu Arg His Gly Phe Gly Val Leu Glu 
        435                 440                 445             


Ser Gly Pro Gln Ala Pro Gln Pro Phe Arg Tyr Thr Gly His Trp Glu 
    450                 455                 460                 


Arg Gly Gln Arg Ser Gly Tyr Gly Ile Glu Glu Asp Gly Asp Arg Gly 
465                 470                 475                 480 


Glu Arg Tyr Ile Gly Met Trp Gln Ala Gly Gln Arg His Gly Pro Gly 
                485                 490                 495     


Val Met Val Thr Gln Ala Gly Val Cys Tyr Gln Gly Thr Phe Gln Ala 
            500                 505                 510         


Asp Lys Thr Val Gly Pro Gly Ile Leu Leu Ser Glu Asp Asp Ser Leu 
        515                 520                 525             


Tyr Glu Gly Thr Phe Thr Arg Asp Leu Thr Leu Met Gly Lys Gly Lys 
    530                 535                 540                 


Val Thr Phe Pro Asn Gly Phe Thr Leu Glu Gly Ser Phe Gly Ser Gly 
545                 550                 555                 560 


Ala Gly Arg Gly Leu His Thr Gln Gly Val Leu Asp Thr Ala Ala Leu 
                565                 570                 575     


Pro Pro Asp Pro Ser Ser Thr Cys Lys Arg Gln Leu Gly Val Gly Ala 
            580                 585                 590         


Phe Pro Val Glu Ser Arg Trp Gln Gly Val Tyr Ser Pro Phe Arg Asp 
        595                 600                 605             


Phe Val Cys Ala Gly Cys Pro Arg Asp Leu Gln Glu Ala Leu Leu Gly 
    610                 615                 620                 


Phe Asp Val Gln Ser Ser Arg Glu Leu Arg Arg Ser Gln Asp Tyr Leu 
625                 630                 635                 640 


Ser Cys Glu Arg Thr His Pro Glu Asp Ser Val Gly Ser Met Glu Asp 
                645                 650                 655     


Ile Leu Glu Glu Leu Leu Gln His Arg Glu Pro Lys Ala Leu Gln Leu 
            660                 665                 670         


Tyr Leu Arg Lys Ala Leu Ser Asn Ser Leu His Pro Leu Gly Lys Leu 
        675                 680                 685             


Leu Arg Thr Leu Met Leu Thr Phe Gln Ala Thr Tyr Ala Gly Val Gly 
    690                 695                 700                 


Ala Asn Lys His Leu Gln Glu Leu Ala Gln Glu Glu Val Lys Gln His 
705                 710                 715                 720 


Ala Gln Glu Leu Trp Ala Ala Tyr Arg Leu Ser Leu Ala Leu Asp Ser 
                725                 730                 735     


Glu His Thr Cys Ser Pro Arg Leu Gly Cys Asp Pro Met Lys His Cys 
            740                 745                 750         


Lys 
    


<210>  9235
<211>  717
<212>  DNA
<213>  Homosapiens

<400>  9235
ggtcccagcc agggtgctgg ggtgctagag gtagagtgag gaccacaccc caggtgtcca     60

gccatccagg ccagcgctcc ttccccagct gcctgtccgc gacaggcctc ttctccttgt    120

ctccctcgct ctcttggtgg ggcggtgttc tccagaattc agcacctggg agccgagatc    180

cacctgatcc gtgacatgat ggaccccaac cacacaggag gcctgtatga cttcctgctc    240

acagccctgg agtcctgtta cgagcacatc cagaaagaag acatgaggct gcaccgctta    300

cctggccact ggcactccag ggagctctgg tagcctggcc tttcctggac agactgaaga    360

gctgagcagg gcactgccag cctgtccctc attacccaag gcaaggggca ggacaggccc    420

tcagaagcag ctcttggagg agatgagcat tttgttttgc acaggaagat gctgctgctg    480

ccctgactgg gatgagggtg aggggtgacg ggtgtggccc tggatgtggt ggttttccct    540

tggccactag cccatcttca atgacccctt aatctgcagc agctcacagg ctgggggtga    600

ggagtccctg gcttctctta gcctgagcct ttctcccaag ttccagagcc tctccgggcc    660

tcagtgctgc catctgtaca atggtggagt gagtacgctg taaaggacct tccattc       717


<210>  9236
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  9236

Met Met Asp Pro Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu Thr 
1               5                   10                  15      


Ala Leu Glu Ser Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg Leu 
            20                  25                  30          


His Arg Leu Pro Gly His Trp His Ser Arg Glu Leu Trp 
        35                  40                  45  


<210>  9237
<211>  1025
<212>  DNA
<213>  Homosapiens

<400>  9237
tgctcatccc aacctgttcc ggtctcccca tcagggacct ccaggtgcat ggattggtgc     60

tgcccctcat gctgcccagc ttctactcag agctcttcac gctctacctg ctgcttcatg    120

agcgggagga cagcttctac agccagggca ttgccaactt gagcctcttt cctgataccc    180

aactgctcga gttcctggat gtgcagaagc acttgtggcc cctcaaggac ctcacgctga    240

cgagcaatca gaggtactcc ctggtcaggg acaagtgttt cctgtcagcc accgagtgcc    300

tgcagaagat catgaccacg gtggacccac gggagaagct ggaggtgctg gagaggacat    360

acggggaaat tgagggcacg gtgtcgaggg tattgggccg ggagtacaag ctgcccatgg    420

acgacctgct gccacttctc atctacgtgg tgtcgcgcgc ccgaattcag cacctgggag    480

ccgagatcca cctgatccgt gacatgatgg accccaacca cacaggaggc ctgtatgact    540

tcctgctcac agccctggag tcctgttacg agcacatcca gaaagaagac atgaggctgc    600

accgcttacc tggccactgg cactccaggg agctctggta gcctggcctt tcctggacag    660

actgaagagc tgagcagggc actgccagcc tgtccctcat tacccaaggc aaggggcagg    720

acaggccctc agaagcagct cttggaggag atgagcattt tgttttgcac aggaagatgc    780

tgctgctgcc ctgactggga tgagggtgag gggtgacggg tgtggccctg gatgtggtgg    840

ttttcccttg gccactagcc catcttcaat gaccccttaa tctgcagcag ctcacaggct    900

gggggtgagg agtccctggc ttctcttagc ctgagccttt ctcccaagtt ccagagcctc    960

tccgggcctc agtgctgcca tctgtacaat ggtggagtga gtacgctgta aaggaccttc   1020

cattc                                                               1025


<210>  9238
<211>  190
<212>  PRT
<213>  Homosapiens

<400>  9238

Met Leu Pro Ser Phe Tyr Ser Glu Leu Phe Thr Leu Tyr Leu Leu Leu 
1               5                   10                  15      


His Glu Arg Glu Asp Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser 
            20                  25                  30          


Leu Phe Pro Asp Thr Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His 
        35                  40                  45              


Leu Trp Pro Leu Lys Asp Leu Thr Leu Thr Ser Asn Gln Arg Tyr Ser 
    50                  55                  60                  


Leu Val Arg Asp Lys Cys Phe Leu Ser Ala Thr Glu Cys Leu Gln Lys 
65                  70                  75                  80  


Ile Met Thr Thr Val Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg 
                85                  90                  95      


Thr Tyr Gly Glu Ile Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu 
            100                 105                 110         


Tyr Lys Leu Pro Met Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val 
        115                 120                 125             


Ser Arg Ala Arg Ile Gln His Leu Gly Ala Glu Ile His Leu Ile Arg 
    130                 135                 140                 


Asp Met Met Asp Pro Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu 
145                 150                 155                 160 


Thr Ala Leu Glu Ser Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg 
                165                 170                 175     


Leu His Arg Leu Pro Gly His Trp His Ser Arg Glu Leu Trp 
            180                 185                 190 


<210>  9239
<211>  6597
<212>  DNA
<213>  Homosapiens

<400>  9239
gagccgcaca ggcagtcccg gcgcggggca accacagcgc tcaggaggcc ctgagtccgg     60

cacctggcca tgtgcaaccc tgaggaggca gctctgctgc ggctggagga ggtcttctca    120

gccaccctcg cccatgtcaa cagccttgtc ctccagcccc tgctcccagc cgccccagat    180

ccctcggatc cctggggcag agagtgcctg cggctcttgc aacagctgca caagagctcc    240

cagcaactct gggaggtgac ggaggaaagc ctgcactcac tgcaggagag gctgcgttac    300

ccggactcca ccggtctgga gtccctgctg ctgctgcgag gtgctgaccg tgtactgcag    360

gcccacatag agtacattga gtcctacaca agctgcatgg tggtgcaggc cttccagaag    420

gcagcaaaga ggagaagcga gtactggcgg ggccagcgga aggcgctgcg gcagctgctt    480

tcaggtgtga gctcagaggg ctcggtgggc gcatcgctgg gccaggccct ccaccagcca    540

ctcgcccatc acgtgcaaca gtacgtgctc ctcctgctga gcctcgggga caccattggg    600

gagcatcacc caacccggga gctggtggtg aacgcagtca ccctctttgg gaacctgcag    660

tccttcatga agcaggagtt ggaccaggct gtggccacac aggctctctg gcacaccctg    720

agaggccggc tgagggatgt gctctgcacc cctgctcaca gactccttca ggacagccag    780

gacgtacccg tgacggtcgc accgttgcgg gctgagcgtg tgctgctctt tgatgatgcc    840

ctcgtcctgc tgcagggcca caatgtccac acctttgatc tgaagctggt gtgggtggat    900

cctgggcagg acgggtgcac gtttcacctc ctcacgcccg aagaagagtt ctccttttgt    960

gccaaggact cccagggcca ggcagtctgg cagtggaagg tgacctgggc tgttcaccag   1020

gccctgcatg ggaagaagga cttccccgtg ctgggggctg gcctggagcc ctcccagcct   1080

cccgactgcc gctgcgcaga atataccttc caggcagagg gccggctctg ccaggccacc   1140

tacgagggcg agtggtgcag gggccggccc cacggcaagg gaaccctgaa atggccggat   1200

gggcggaatc acgtggggaa tttctgccag ggcctggagc atggcttcgg catccgcctg   1260

ctgccccagg cctctgagga caagttcgac tgttacaagt gtcactggcg agaaggcagc   1320

atgtgtggct acggcatctg tgagtacagc accgacgagg tgtacaaggg ctacttccag   1380

gagggcctgc ggcacggatt tggggtcctt gagagtggtc cgcaggcccc ccagcccttc   1440

aggtacacgg gccactggga gaggggccag aggagcggct atggcattga ggaggatggt   1500

gacaggtgag cgccctgcag ccaccactcc caggacggag gggtggaccg ggccctcaca   1560

gaccagattg ttgcaggaca caggctcctg tttgtccccc actgtgtctc tcttaagccc   1620

ctcacttccc ctccagtccc tcggttgctg cggaggctca ggctgagcga atcttggtca   1680

cgctgactgc agggtcgccc ccgcccctca cccctcctca tggtgttgga gaggcatttc   1740

tgaccccctg ctctgtcacg tctaaaaact gcagcccttg ctggctctct gggctgtgtg   1800

ataaagccct ggatccttgg cctggcaatc acagcctcgc ctgcttctct gacctcaccc   1860

cagctgcgtc tcctgggcac ccctccagcc tttctggacc actgaagtcc ccacgtatcc   1920

atcacatgct cctacctcca tggctttgca cacactccta ttccccctgt ccttcctgcc   1980

acctccacgg agaagcctcc cagatgccct tcccaggctg cctccctccc tcctccattc   2040

tctattcctc ttgggggtcc tgacctctct ggcactgtgt ctgttgagtg gattcaggtg   2100

atgtcactgc cccttatctg cactccctgc cgccccgtgc cagcagagtg cccaggaggt   2160

acatgggaat gagtctgatc caactctggc cacattcctc tccttccaga ggtgagcgct   2220

acattggcat gtggcaggct ggtcagcgcc acggcccagg ggtcatggtc acccaggcag   2280

gtgtctgcta ccagggcacc ttccaggcgg acaagacggt ggtgagtgga gtgtatcctg   2340

ggctatccct ctctttgcac cccactcccg ctgggggcac tgaggctgag ctgaggcctt   2400

tcagggaggg atgggaaagg gggctgtgtt cctgggtgct ggagggagcc agaacctggg   2460

caggaagcca gctctaccac ccacctcccc tggccctggc caatccctgc tctgcctgac   2520

cttggtttcc ccatcagcaa ctcaggttaa gaatacttac catagactca atgaactaac   2580

aagaatggag cacttgctca tgatgatgca ttagctgaca ttcacagagt cctaacttga   2640

cacctggctc tgggctaagc tcccaccctg atcttgtggg atcttcccaa gagccctgca   2700

ggttgatgtc attattatcc ctagtgtgtc cctagtgaat gacaaatgag aggttcagag   2760

ggatcagagg acctgctcca tgtcaccttc actgagtggc agagctgaca ctcacaccct   2820

ggtctgctga gcctggccgc cgagcctggg actcccatgt ttgcctcacc catacccttc   2880

caggtgcctg gggaatgtgg ggctctggcc tgatggctgt tcctgttatt atggtctgtt   2940

ggtttgttta tgctctactt cattctcgaa aggattgaag gaggccttca aggaaagagg   3000

aagacaaggg gaagaataag tacacaaaat agatttggaa ataagccgaa cactaattgt   3060

aaccctttcg gctctgagct tcccggcagc ccatggggca agggagcctg gtcagctctg   3120

ccgttcccag ggccagtgac aagcagggaa gcagggatgt ttcagagaaa gccccacatt   3180

tcttgagctc ccaagggctt cctgaagaag ccgctggggt gaggagccag ggcggagggt   3240

gtcatttggg gaaatccagg gatggggtcc tcggggctgg tgcttagcag gccaaaggct   3300

agagtcccaa ttaggtacag tcctgtgggg cgtgatgagg ctcagggccc ctctcgccat   3360

gtgtcagggc acatctccct tctttggcca tctctctcca ccctgagttt cctggccctt   3420

cctcacccac cctttctacc ctccctggct tcctctcccc aagggcccgg gcatcctcct   3480

ctctgaagac gactccctgt atgagggcac cttcaccagg gacctgaccc tcatggggaa   3540

gggcaaggtc accttcccca atggcttcac cctggagggc tcgttcggca gtggggcagg   3600

gagaggactg cacacacagg gtgtgctgga cacggctgcc ctcccaccag acccgagcag   3660

tacctgcaag aggcagctgg gcgtgggtgc cttccccgtg gaaagccgct ggcagggagt   3720

ctacagcccc ttccgggact ttgtgtgtgc tggctgcccc agggacctgc aggaggccct   3780

gctgggcttc gacgtgcaga gctccaggga gctgcgtagg tctcaggatt acctgtcctg   3840

cgagaggacc caccctgagg acagtgtggg cagtatggaa gacatcctgg aggagctgct   3900

gcagcaccgg gagcccaagg ccctgcagct gtacctcagg aaggctctga gcaactcact   3960

gcaccccctg ggaaagctgc tccggacact gatgctgacc ttccaggcta cctacgcagg   4020

tgtcggggcc aacaagcacc tgcaggagct ggcccaggag gaggtgaagc agcatgccca   4080

ggaactctgg gctgcctaca ggtgggctcg gtggcaaacg ggacagctac tgccctgtga   4140

cactagtgtg ccctttccag gcatcagttc tgccttgcat ttgggaggaa tgccaagtgt   4200

ctgattcaac aatgaaccag aggcttggtc agtgtgcagc tgctgagcaa aagggttaga   4260

gggtggggag gtgagagcaa aggcccagct gcagccctca gctagagtcc aagacccaac   4320

caggcgctgg gctgactctg accgcaggtg cactctcacc ccactgtagg ctgagcttgg   4380

ccctggactc ggaacacacc tgcagtccca ggctgggctg tgaccccatg aaacactgca   4440

aatagaagcc ttagatgcta tagttccttc tgctgctgga ttctcaggct aacatcctgg   4500

agctccaacc ttctaacttc tgtggtttga gaggatgaac cctgcaggcc atgtccacag   4560

ttctgagagg ccacctgctt ttgcctttgt tgactggtgg tagaactcca gttctgtggc   4620

aaggggcagc cacaccattt ctctctcatt gactcacagg ggtctgctgc gagttgcctt   4680

agagcgcaag ggccaggccc tggaggagga tgaagacaca gagacaaggt gactggcgca   4740

ggtctccttg gggcctgccg tgtccaggga ggcctcatgc gtctgctcct aggacctccc   4800

ttggggaaag aggtgcttct ggggaagtgc tgggcattca ctctattgac caaacattgt   4860

gcattgatcg tttgtggatt agaatgaccc atgacctctg ttctgtgagg aaccagggag   4920

ggggcactgc tacaatgcat tgaatgcatc tttgttctaa atgtatgatc ccaatctcat   4980

ctttcgcatg cagaaggtga gtagctcccc gaggcaccct cctctccctg cacacagatg   5040

gggaaaccga gggctggtag ggatgagcct gaggttatac aggagttagg tgggcatgaa   5100

atttgtttcc cccagtccct ggagcaaacc ttacaatttg cctttagatt ctagacctga   5160

aagtgttcct gatcagagag gccttcctgt cactgccttg caggaggcaa gggaaatggg   5220

gttagacatt agggaggatt ccccgcccgg agtcctagca cagcaaacca ggaggtggaa   5280

ctgaatcagc ctggaatggc tgctgagagc tcagctgcaa gttgctggtc catctggggc   5340

cctggttttg ctttcagtca aatggggatc caactcctgc cccacctgcc atcttggttg   5400

tcaaagtcaa aggagggaat gaagttatga attgaattgg gcaaatgatg actgagaaca   5460

ggcttggaaa aggttttctg gggaggagga ggctggaggc caggacactg tttgttgtgg   5520

aactaggagc tctttgagac gagactccaa gtagtaatcc cagaccccac cttgctcatc   5580

ccaacctgtt ccggtctccc catcagggac ctccaggtgc atggattggt gctgcccctc   5640

atgctgccca gcttctactc agagctcttc acgctctacc tgctgcttca tgagcgggag   5700

gacagcttct acagccaggg cattgccaac ttgagcctct ttcctgatac ccaactgctc   5760

gagttcctgg atgtgcagaa gcacttgtgg cccctcaagg acctcacgct gacgagcaat   5820

cagaggtact ccctggtcag ggacaagtgt ttcctgtcag ccaccgagtg cctgcagaag   5880

atcatgacca cggtggaccc acgggagaag ctggaggtgc tggagaggac atacggggaa   5940

attgagggca cggtgtcgag ggtattgggc cgggagtaca agctgcccat ggacgacctg   6000

ctgccacttc tcatctacgt ggtgtcgcgc gcccgaattc agcacctggg agccgagatc   6060

cacctgatcc gtgacatgat ggaccccaac cacacaggag gcctgtatga cttcctgctc   6120

acagccctgg agtcctgtta cgagcacatc cagaaagaag acatgaggct gcaccgctta   6180

cctggccact ggcactccag ggagctctgg tagcctggcc tttcctggac agactgaaga   6240

gctgagcagg gcactgccag cctgtccctc attacccaag gcaaggggca ggacaggccc   6300

tcagaagcag ctcttggagg agatgagcat tttgttttgc acaggaagat gctgctgctg   6360

ccctgactgg gatgagggtg aggggtgacg ggtgtggccc tggatgtggt ggttttccct   6420

tggccactag cccatcttca atgacccctt aatctgcagc agctcacagg ctgggggtga   6480

ggagtccctg gcttctctta gcctgagcct ttctcccaag ttccagagcc tctccgggcc   6540

tcagtgctgc catctgtaca atggtggagt gagtacgctg taaaggacct tccattc      6597


<210>  9240
<211>  479
<212>  PRT
<213>  Homosapiens

<400>  9240

Met Cys Asn Pro Glu Glu Ala Ala Leu Leu Arg Leu Glu Glu Val Phe 
1               5                   10                  15      


Ser Ala Thr Leu Ala His Val Asn Ser Leu Val Leu Gln Pro Leu Leu 
            20                  25                  30          


Pro Ala Ala Pro Asp Pro Ser Asp Pro Trp Gly Arg Glu Cys Leu Arg 
        35                  40                  45              


Leu Leu Gln Gln Leu His Lys Ser Ser Gln Gln Leu Trp Glu Val Thr 
    50                  55                  60                  


Glu Glu Ser Leu His Ser Leu Gln Glu Arg Leu Arg Tyr Pro Asp Ser 
65                  70                  75                  80  


Thr Gly Leu Glu Ser Leu Leu Leu Leu Arg Gly Ala Asp Arg Val Leu 
                85                  90                  95      


Gln Ala His Ile Glu Tyr Ile Glu Ser Tyr Thr Ser Cys Met Val Val 
            100                 105                 110         


Gln Ala Phe Gln Lys Ala Ala Lys Arg Arg Ser Glu Tyr Trp Arg Gly 
        115                 120                 125             


Gln Arg Lys Ala Leu Arg Gln Leu Leu Ser Gly Val Ser Ser Glu Gly 
    130                 135                 140                 


Ser Val Gly Ala Ser Leu Gly Gln Ala Leu His Gln Pro Leu Ala His 
145                 150                 155                 160 


His Val Gln Gln Tyr Val Leu Leu Leu Leu Ser Leu Gly Asp Thr Ile 
                165                 170                 175     


Gly Glu His His Pro Thr Arg Glu Leu Val Val Asn Ala Val Thr Leu 
            180                 185                 190         


Phe Gly Asn Leu Gln Ser Phe Met Lys Gln Glu Leu Asp Gln Ala Val 
        195                 200                 205             


Ala Thr Gln Ala Leu Trp His Thr Leu Arg Gly Arg Leu Arg Asp Val 
    210                 215                 220                 


Leu Cys Thr Pro Ala His Arg Leu Leu Gln Asp Ser Gln Asp Val Pro 
225                 230                 235                 240 


Val Thr Val Ala Pro Leu Arg Ala Glu Arg Val Leu Leu Phe Asp Asp 
                245                 250                 255     


Ala Leu Val Leu Leu Gln Gly His Asn Val His Thr Phe Asp Leu Lys 
            260                 265                 270         


Leu Val Trp Val Asp Pro Gly Gln Asp Gly Cys Thr Phe His Leu Leu 
        275                 280                 285             


Thr Pro Glu Glu Glu Phe Ser Phe Cys Ala Lys Asp Ser Gln Gly Gln 
    290                 295                 300                 


Ala Val Trp Gln Trp Lys Val Thr Trp Ala Val His Gln Ala Leu His 
305                 310                 315                 320 


Gly Lys Lys Asp Phe Pro Val Leu Gly Ala Gly Leu Glu Pro Ser Gln 
                325                 330                 335     


Pro Pro Asp Cys Arg Cys Ala Glu Tyr Thr Phe Gln Ala Glu Gly Arg 
            340                 345                 350         


Leu Cys Gln Ala Thr Tyr Glu Gly Glu Trp Cys Arg Gly Arg Pro His 
        355                 360                 365             


Gly Lys Gly Thr Leu Lys Trp Pro Asp Gly Arg Asn His Val Gly Asn 
    370                 375                 380                 


Phe Cys Gln Gly Leu Glu His Gly Phe Gly Ile Arg Leu Leu Pro Gln 
385                 390                 395                 400 


Ala Ser Glu Asp Lys Phe Asp Cys Tyr Lys Cys His Trp Arg Glu Gly 
                405                 410                 415     


Ser Met Cys Gly Tyr Gly Ile Cys Glu Tyr Ser Thr Asp Glu Val Tyr 
            420                 425                 430         


Lys Gly Tyr Phe Gln Glu Gly Leu Arg His Gly Phe Gly Val Leu Glu 
        435                 440                 445             


Ser Gly Pro Gln Ala Pro Gln Pro Phe Arg Tyr Thr Gly His Trp Glu 
    450                 455                 460                 


Arg Gly Gln Arg Ser Gly Tyr Gly Ile Glu Glu Asp Gly Asp Arg 
465                 470                 475                 


<210>  9241
<211>  1823
<212>  DNA
<213>  Homosapiens

<400>  9241
ggcggcgcgg gaacctgaca ccgaggatga ataaatgatg ctcgctgact acccgtggcc     60

aaagcccgtg gccaccgagc gccggctggc aggggcagtg accggcggcc ggcccgttcg    120

tccctgggct ccgcaagcgg cgcggtggca cgaagatggc ggggtggccg ggcgcgggtc    180

ccctctgcgt gctgggcggc gccgcactcg gggtgtgcct cgcgggggtt gccgggcagc    240

tggtggagcc cagcacggcc ccacccaagc ccaagccgcc tccgctgacc aaggagacag    300

tggtgttctg ggacatgcgc ctgtggcacg tggtgggcat cttttcgctc ttcgtgttgt    360

ccatcatcat cacgctgtgc tgtgtcttca actgtcgtgt gccacggacc cggaaggaga    420

tcgaagcccg gtacctgcag cgaaaggcag ccaagatgta cacagacaag ctggagactg    480

tgccacccct caatgagctc acagaagtcc caggagagga taagaagaag aagaagaaga    540

agaagaagga cagtgtggac acagtggcca tcaaagtaga ggaggatgag aagaatgagg    600

ccaagaagaa gaaaggagag aaatgaagac atcctgggca gcttgggctg gcgggccctg    660

gagctcaagc cgtggccggg gtccaggcat gttggactct gagctcattt ggggaccaca    720

gaggctgtgg tcagagaggg aagctgaggc ccatggccac atcctcatgg cccatcaggg    780

gcaggaacca gacaatctcg taggtgtcct gccccccagc ctaggcttgg ctcctttcac    840

cccatccaca tgggtactgt ctcggcagag gtggtctggt gccaccgtcc ctctgcagat    900

acactgctct ccccacccag acctgcctgt ctcccaccct ttctgccagg gatggcagtg    960

gctgtgaagg agtaatggga tatggggtta cttcagccac cctttctggc acgaaatggc   1020

tgaagtgcat gggtcagggt gtgaggccac acccagagta gccatgagga ggcagagagg   1080

gtcactgggg gacactgtgg cagcaggagg gactctgtct ggccagggag gagccccagt   1140

ggtgagaaga cttccccaag cctggcaggg gatccagctc aagggagtaa gtagaggtgg   1200

cttcagaaat ggaaccccca gcccagcaga catcaagctc aaggcaatgg gctaccctca   1260

tttcacacgt tgtgatgaag ctgaggctgc tgccaggccc ggcatgaggc cccgaggctc   1320

gagctcgggg ctgggggctg cagggctggg tcaggggtac acagagctaa ggccaatggg   1380

ctagagggtg ccggaaagag agctggagtc tgggctcctc ttgggaatca gagtatattt   1440

aagaagccaa gggggacctc gggctgttct ggtggcccct tctatgccca gctgtgctgg   1500

gaggtcccag ggccctagaa gatcacagca gggccttctg cctgctgacc ataacagtgc   1560

cagcttcttt gcagcttcct cttctaccat ttcccactac gggcacctaa aagaagcatc   1620

tctgaccaga agacaaaggc ccaaatagca cctgggggag ggaagatgca cagaggcact   1680

tccagatggc atcgaacaga ctaaggctct gaaacctagg cctgaacact aaggtctcga   1740

gacaccagag gtttctgagc caggagagcc tgctggaaaa gcagcctgca gagatttgtg   1800

aataaagctg attgccttct cag                                           1823


<210>  9242
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  9242

Met Ala Gly Trp Pro Gly Ala Gly Pro Leu Cys Val Leu Gly Gly Ala 
1               5                   10                  15      


Ala Leu Gly Val Cys Leu Ala Gly Val Ala Gly Gln Leu Val Glu Pro 
            20                  25                  30          


Ser Thr Ala Pro Pro Lys Pro Lys Pro Pro Pro Leu Thr Lys Glu Thr 
        35                  40                  45              


Val Val Phe Trp Asp Met Arg Leu Trp His Val Val Gly Ile Phe Ser 
    50                  55                  60                  


Leu Phe Val Leu Ser Ile Ile Ile Thr Leu Cys Cys Val Phe Asn Cys 
65                  70                  75                  80  


Arg Val Pro Arg Thr Arg Lys Glu Ile Glu Ala Arg Tyr Leu Gln Arg 
                85                  90                  95      


Lys Ala Ala Lys Met Tyr Thr Asp Lys Leu Glu Thr Val Pro Pro Leu 
            100                 105                 110         


Asn Glu Leu Thr Glu Val Pro Gly Glu Asp Lys Lys Lys Lys Lys Lys 
        115                 120                 125             


Lys Lys Lys Asp Ser Val Asp Thr Val Ala Ile Lys Val Glu Glu Asp 
    130                 135                 140                 


Glu Lys Asn Glu Ala Lys Lys Lys Lys Gly Glu Lys 
145                 150                 155     


<210>  9243
<211>  1861
<212>  DNA
<213>  Homosapiens

<400>  9243
ggcggcgcgg gaacctgaca ccgaggatga ataaatgatg ctcgctgact acccgtggcc     60

aaagcccgtg gccaccgagc gccggctggc aggggcagtg accggcggcc ggcccgttcg    120

tccctgggct ccgcaagcgg cgcggtggca cgaagatggc ggggtggccg ggcgcgggtc    180

ccctctgcgt gctgggcggc gccgcactcg gggtgtgcct cgcgggggtt gccgggcagc    240

tggtggagcc cagcacggcc ccacccaagc ccaagccgcc tccgctgacc aaggagacag    300

tggtgttctg ggacatgcgc ctgtggcacg tggtgggcat cttttcgctc ttcgtgttgt    360

ccatcatcat cacgctgtgc tgtgtcttca actgtcgtgt gccacggacc cggaaggaga    420

tcgaagcccg gtacctgcag cgaaaggcag ccaagatgta cacagacaag ctggagactg    480

tgccacccct caatgagctc acagaagtcc caggagagga taagaagaag aagaagaaga    540

agaagaagga cagtgtggac acagtggcca tcaaagtaga ggaggatgag aagaatgagg    600

ccaagaagaa gaaaggagag aaatgaagac atcctgggca gcttgggctg gcgggccctg    660

gagctcaagc cgtggccggg gtccaggcat gttggactct gagctcattt ggggaccaca    720

gaggctgtgg tcagagaggg aagctgaggc ccatggccac atcctcatgg cccatcaggg    780

gcaggaacca gacaatctcg taggtgtcct gccccccagc ctaggcttgg ctcctttcac    840

cccatccaca tgggtactgt ctcggcagag gtggtctggt gccaccgtcc ctctgcagat    900

acactgctct ccccacccag acctgcctgt ctcccaccct ttctgccagg gatggcagtg    960

gctgtgaagg agtaatggga tatggggtta cttcagccac cctttctggc acgaaatggc   1020

tgaagtgcat gggtcagggt gtgaggccac acccagagta gccatgagga ggcagagagg   1080

gtcactgggg gacactgtgg cagcaggagg gactctgtct ggccagggag gagccccagt   1140

ggtgagaaga cttccccaag cctggcaggg gatccagctc aagggagtaa gtagaggtgg   1200

cttcagaaat ggaaccccca gcccagcaga catcaagctc aaggcaatgg gctaccctca   1260

tttcacacgt tgtgatgaag ctgaggctgc tgccaggccc ggcatgaggc cccgaggctc   1320

gagctcgggg ctgggggctg cagggctggg tcaggggtac acagagctaa ggccaatggg   1380

ctagagggtg ccggaaagag agctggagtc tgggctcctc ttgggaatca gagtatattt   1440

aagaagccaa gggggacctc gggctgttct ggtggcccct tctatgccca gctgtgctgg   1500

gaggtcccag ggccctagaa gatcacagca gggccttctg cctgctgacc ataacagtgc   1560

cagcttcttt gcagcttcct cttctaccat ttcccactac gggcacctaa aagaagcatc   1620

tctgaccaga agacaaaggc ccaaatagca cctgggggag ggaagatgca cagaggcact   1680

tccagatggc atcgaacaga ctaaggctct gaaacctagg cctgaacact aaggtctcga   1740

gacaccagag gtttctgagc caggagagcc tgctggaaaa gcagcctgca gagatttgtg   1800

aataaagctg attgccttct cagagccagg cctagaaaat ggcctcctga gatgacccct   1860

c                                                                   1861


<210>  9244
<211>  156
<212>  PRT
<213>  Homosapiens

<400>  9244

Met Ala Gly Trp Pro Gly Ala Gly Pro Leu Cys Val Leu Gly Gly Ala 
1               5                   10                  15      


Ala Leu Gly Val Cys Leu Ala Gly Val Ala Gly Gln Leu Val Glu Pro 
            20                  25                  30          


Ser Thr Ala Pro Pro Lys Pro Lys Pro Pro Pro Leu Thr Lys Glu Thr 
        35                  40                  45              


Val Val Phe Trp Asp Met Arg Leu Trp His Val Val Gly Ile Phe Ser 
    50                  55                  60                  


Leu Phe Val Leu Ser Ile Ile Ile Thr Leu Cys Cys Val Phe Asn Cys 
65                  70                  75                  80  


Arg Val Pro Arg Thr Arg Lys Glu Ile Glu Ala Arg Tyr Leu Gln Arg 
                85                  90                  95      


Lys Ala Ala Lys Met Tyr Thr Asp Lys Leu Glu Thr Val Pro Pro Leu 
            100                 105                 110         


Asn Glu Leu Thr Glu Val Pro Gly Glu Asp Lys Lys Lys Lys Lys Lys 
        115                 120                 125             


Lys Lys Lys Asp Ser Val Asp Thr Val Ala Ile Lys Val Glu Glu Asp 
    130                 135                 140                 


Glu Lys Asn Glu Ala Lys Lys Lys Lys Gly Glu Lys 
145                 150                 155     


<210>  9245
<211>  820
<212>  DNA
<213>  Homosapiens

<400>  9245
ggcgtgatgt tatctactca gtgagggtgg ggagtccgtg gattgaccag atgacgcaga     60

ccgcctccga tgtcccggtg ctccaggtca tcatgcatag caggtaccgg gcccagcggt    120

tctggtcctg ggtgggccag gccaacgaca tcggcctcct caagctcaag caggaactca    180

agtacagcaa ttacgtgcgg cccatctgcc tgcctggcac ggactatgtg ttgaaggacc    240

attcccgctg cactgtgacg ggctggggac tttccaaggc tgacggcatg tggcctcagt    300

tccggaccat tcaggagaag gaagtcatca tcctgaacaa caaagagtgt gacaatttct    360

accacaactt caccaaaatc cccactctgg ttcagatcat caagtcccag atgatgtgtg    420

cggaggacac ccacagggag aagttctgct atgagctaac tggagagccc ttggtctgct    480

ccatggaggg cacgtggtac ctggtgggat tggtgagctg gggtgcaggc tgccagaaga    540

gcgaggcccc acccatctac ctacaggtct cctcctacca acactggatc tgggactgcc    600

tcaacgggca ggccctggcc ctgccagccc catccaggac cctgctcctg gcactcccac    660

tgcccctcag cctccttgct gccctctgac tctgtgtgcc ctccctcact tgtgggcccc    720

ccttgcctcc gtgcccaggt tgctgtgggt gcagctgtca cagccctgag agtcagggtg    780

gagatgaggt gctcaattaa acattactgt tttccatgcc                          820


<210>  9246
<211>  212
<212>  PRT
<213>  Homosapiens

<400>  9246

Met Thr Gln Thr Ala Ser Asp Val Pro Val Leu Gln Val Ile Met His 
1               5                   10                  15      


Ser Arg Tyr Arg Ala Gln Arg Phe Trp Ser Trp Val Gly Gln Ala Asn 
            20                  25                  30          


Asp Ile Gly Leu Leu Lys Leu Lys Gln Glu Leu Lys Tyr Ser Asn Tyr 
        35                  40                  45              


Val Arg Pro Ile Cys Leu Pro Gly Thr Asp Tyr Val Leu Lys Asp His 
    50                  55                  60                  


Ser Arg Cys Thr Val Thr Gly Trp Gly Leu Ser Lys Ala Asp Gly Met 
65                  70                  75                  80  


Trp Pro Gln Phe Arg Thr Ile Gln Glu Lys Glu Val Ile Ile Leu Asn 
                85                  90                  95      


Asn Lys Glu Cys Asp Asn Phe Tyr His Asn Phe Thr Lys Ile Pro Thr 
            100                 105                 110         


Leu Val Gln Ile Ile Lys Ser Gln Met Met Cys Ala Glu Asp Thr His 
        115                 120                 125             


Arg Glu Lys Phe Cys Tyr Glu Leu Thr Gly Glu Pro Leu Val Cys Ser 
    130                 135                 140                 


Met Glu Gly Thr Trp Tyr Leu Val Gly Leu Val Ser Trp Gly Ala Gly 
145                 150                 155                 160 


Cys Gln Lys Ser Glu Ala Pro Pro Ile Tyr Leu Gln Val Ser Ser Tyr 
                165                 170                 175     


Gln His Trp Ile Trp Asp Cys Leu Asn Gly Gln Ala Leu Ala Leu Pro 
            180                 185                 190         


Ala Pro Ser Arg Thr Leu Leu Leu Ala Leu Pro Leu Pro Leu Ser Leu 
        195                 200                 205             


Leu Ala Ala Leu 
    210         


<210>  9247
<211>  1802
<212>  DNA
<213>  Homosapiens

<400>  9247
atccgttaga aggagcattg aggagtagat acccacttgc catggcctgt gggccggggg     60

atcttcaaag ccttacatct ccgctttcct ctgccagatt agattatcag ccgtctattg    120

aagggccctg gctccgggcc tgcggtcaga ccaacgtgtc ctgcagggtg gtgaagggga    180

agctggtaga ggtaggcaag tggccatggc agattcaagg acctcagcct gtactccgtg    240

atggtgggag tccaccagcg cccagaaaat agcactcagc tcccgctcac tcgcatggtg    300

attcataagg atttcagcaa tctcatgtct caggacattg ccctcctaaa gctcagggac    360

tccatctcgt ggtccccctt cgtccagcct gtctgcctcc ctaacatcaa attcaagcca    420

tccattggaa gcatgtgctg ggtaatcggc tggggaacta cagggaaaaa aggttgactc    480

tggaagctcc cttgtctgcc aaatggacaa gacctggatt cagataggag tggtaagctg    540

gagctttagt tgtggccagc gccacttccc agttccttgg gcaaagcccc actggagggg    600

ctggagggaa agtagggtca cttggagatc ctggatgcca gcccctgagg tttggtcttc    660

atctcactgc gggaggggtg acaccatgag ccagtccagg gcaatgggct gcgaggccgg    720

cctcgccttc tctggcagac cccgaccacc cagacactgc cctcgaccac catggagacc    780

caattcccag tttctgaagg caaagtcgac ccataccgct cctgtggctt ttcctacgag    840

caggacccca ccctcaggga cccagaagcc gtggctcggc ggtggccctg gatggtcagc    900

gtgcgggcca atggcacaca catctgtgcc ggcaccatca ttgcctccca gtgggtgctg    960

actgtggccc actgcctgat ctggcgtgat gttatctact cagtgagggt ggggagtccg   1020

tggattgacc agatgacgca gaccgcctcc gatgtcccgg tgctccaggt catcatgcat   1080

agcaggtacc gggcccagcg gttctggtcc tgggtgggcc aggccaacga catcggcctc   1140

ctcaagctca agcaggaact caagtacagc aattacgtgc ggcccatctg cctgcctggc   1200

acggactatg tgttgaagga ccattcccgc tgcactgtga cgggctgggg actttccaag   1260

gctgacggca tgtggcctca gttccggacc attcaggaga aggaagtcat catcctgaac   1320

aacaaagagt gtgacaattt ctaccacaac ttcaccaaaa tccccactct ggttcagatc   1380

atcaagtccc agatgatgtg tgcggaggac acccacaggg agaagttctg ctatgagcta   1440

actggagagc ccttggtctg ctccatggag ggcacgtggt acctggtggg attggtgagc   1500

tggggtgcag gctgccagaa gagcgaggcc ccacccatct acctacaggt ctcctcctac   1560

caacactgga tctgggactg cctcaacggg caggccctgg ccctgccagc cccatccagg   1620

accctgctcc tggcactccc actgcccctc agcctccttg ctgccctctg actctgtgtg   1680

ccctccctca cttgtgggcc ccccttgcct ccgtgcccag gttgctgtgg gtgcagctgt   1740

cacagccctg agagtcaggg tggagatgag gtgctcaatt aaacattact gttttccatg   1800

cc                                                                  1802


<210>  9248
<211>  299
<212>  PRT
<213>  Homosapiens

<400>  9248

Met Glu Thr Gln Phe Pro Val Ser Glu Gly Lys Val Asp Pro Tyr Arg 
1               5                   10                  15      


Ser Cys Gly Phe Ser Tyr Glu Gln Asp Pro Thr Leu Arg Asp Pro Glu 
            20                  25                  30          


Ala Val Ala Arg Arg Trp Pro Trp Met Val Ser Val Arg Ala Asn Gly 
        35                  40                  45              


Thr His Ile Cys Ala Gly Thr Ile Ile Ala Ser Gln Trp Val Leu Thr 
    50                  55                  60                  


Val Ala His Cys Leu Ile Trp Arg Asp Val Ile Tyr Ser Val Arg Val 
65                  70                  75                  80  


Gly Ser Pro Trp Ile Asp Gln Met Thr Gln Thr Ala Ser Asp Val Pro 
                85                  90                  95      


Val Leu Gln Val Ile Met His Ser Arg Tyr Arg Ala Gln Arg Phe Trp 
            100                 105                 110         


Ser Trp Val Gly Gln Ala Asn Asp Ile Gly Leu Leu Lys Leu Lys Gln 
        115                 120                 125             


Glu Leu Lys Tyr Ser Asn Tyr Val Arg Pro Ile Cys Leu Pro Gly Thr 
    130                 135                 140                 


Asp Tyr Val Leu Lys Asp His Ser Arg Cys Thr Val Thr Gly Trp Gly 
145                 150                 155                 160 


Leu Ser Lys Ala Asp Gly Met Trp Pro Gln Phe Arg Thr Ile Gln Glu 
                165                 170                 175     


Lys Glu Val Ile Ile Leu Asn Asn Lys Glu Cys Asp Asn Phe Tyr His 
            180                 185                 190         


Asn Phe Thr Lys Ile Pro Thr Leu Val Gln Ile Ile Lys Ser Gln Met 
        195                 200                 205             


Met Cys Ala Glu Asp Thr His Arg Glu Lys Phe Cys Tyr Glu Leu Thr 
    210                 215                 220                 


Gly Glu Pro Leu Val Cys Ser Met Glu Gly Thr Trp Tyr Leu Val Gly 
225                 230                 235                 240 


Leu Val Ser Trp Gly Ala Gly Cys Gln Lys Ser Glu Ala Pro Pro Ile 
                245                 250                 255     


Tyr Leu Gln Val Ser Ser Tyr Gln His Trp Ile Trp Asp Cys Leu Asn 
            260                 265                 270         


Gly Gln Ala Leu Ala Leu Pro Ala Pro Ser Arg Thr Leu Leu Leu Ala 
        275                 280                 285             


Leu Pro Leu Pro Leu Ser Leu Leu Ala Ala Leu 
    290                 295                 


<210>  9249
<211>  2960
<212>  DNA
<213>  Homosapiens

<400>  9249
gctccaagtt gccgccagaa cccatggccg gcgtggaaac cgctgcgagg cggcgccacg     60

acggaggctg aggtcgccgg cagtatccat ggcgtcccag agcggcagct ccctggggct    120

cctggcctgg ttcttgcttc ttcagccatg gctcgaagag gcccgggcag gcagggtggg    180

tgcgcaggga ggcgtagcac tgctcttccc ctccgcgctc ccctcagggc caggcggcca    240

ggaccccgga gcgagcggat gggagccgcc acctgtaggg gctccaggat ccccagcggc    300

cccccagtcc agggggaacg cagtgcgccc cgcttcggtg ttacttccct caggtgagcc    360

ataccgaccc gaggaggatt ccagaatgac cccggcaagc ccagaagccc ggacgtctcc    420

tgtgcacccg aaattcccca aaattccaga aacttctgta gctccagggt ctccagcgac    480

cgcagggcct ccaggatcct gggttacttc agcatctaca gtgggagaag ccttggaatc    540

cgacggaatc tctgaccttg gaaggcagtt ttctcagggt attgtttctg gtgctagatc    600

tgtcctggcc tgcggggtag gtcaaagggg acacagcctg gctcagggag gttgagggtc    660

agaccctgac ctagatgatt tgagagagag gatagataac ccgcctccgc cctgggcagc    720

ctggtggggt ggtgggaagg tagtggcttc acttccagtc ccctctcttt actgagccca    780

ccagcctgtg gccaccgtgt ttcaaggatg attggaggat tgccagcccc aaacaagaag    840

tggccctggc aggtgagcct gcagaccagc aacatacacc actgcggagg ctccctcatc    900

gacaggcgct gggtgctcac tgccgcccac tgtgtcttta gtttcaggac caatgccact    960

tgttcttcag gagactgagc taaacattat gcgtcatgag aaatgttgtg agatgctcaa   1020

gaacaagaat atatccaaga gtaaaatggt cacgaggggg accgtctgtg gctataatga   1080

ccaagggaag gatgcctgtc aggttataaa gaggacacaa ccaatccagg ttgactctgg   1140

aagctccctt gtctgccaaa tggacaagac ctggattcag ataggagtgt tccttgggca   1200

aagccccact ggaggggctg gagggaaagt agggtcactt ggagatcctg gatgccagcc   1260

cctgaggttt ggtcttcatc tcactgcggg aggggtgaca ccatgagcca gtccagggca   1320

atgggctgcg agggtgagga ggtctgagaa tcggccgaga ttaagttgag ggactccagg   1380

agactgcttg gaccagcgga gtgaggagag ggaggggcca aggagggaag tcagccgggg   1440

cgtacccagc ccgggaggta taagggaggg ctgtcactag gggcgccctt gcgggtcaga   1500

caccacgagc gccgtggcgg gtggcccctg gggggcgcca cgcaggcggg gcactaggag   1560

catccccacc cagctcacca gaggccgcgg catgcggcca acagggggcg ccgtcgtggg   1620

ggcggcactg ggagcgcctt ccggagagac gcagtcggct gccaccccgg gatgggtcgc   1680

tggtgccaga ccgtcgcgcg cgggcagcgc ccccggacgt ctgccccctc ccgcgccggt   1740

gccctgctgc tgctgcttct gttgctgagg tctgcaggtt gctggggcgc aggggaagcc   1800

ccgggggcgc tgtccactgc tgatcccgcc gaccagagcg tccagtgtgt ccccaaggcc   1860

acctgtcctt ccagccggcc tcgccttctc tggcagaccc cgaccaccca gacactgccc   1920

tcgaccacca tggagaccca attcccagtt tctgaaggca aagtcgaccc ataccgctcc   1980

tgtggctttt cctacgagca ggaccccacc ctcagggacc cagaagccgt ggctcggcgg   2040

tggccctgga tggtcagcgt gcgggccaat ggcacacaca tctgtgccgg caccatcatt   2100

gcctcccagt gggtgctgac tgtggcccac tgcctgatct ggcgtgatgt tatctactca   2160

gtgagggtgg ggagtccgtg gattgaccag atgacgcaga ccgcctccga tgtcccggtg   2220

ctccaggtca tcatgcatag caggtaccgg gcccagcggt tctggtcctg ggtgggccag   2280

gccaacgaca tcggcctcct caagctcaag caggaactca agtacagcaa ttacgtgcgg   2340

cccatctgcc tgcctggcac ggactatgtg ttgaaggacc attcccgctg cactgtgacg   2400

ggctggggac tttccaaggc tgacggcatg tggcctcagt tccggaccat tcaggagaag   2460

gaagtcatca tcctgaacaa caaagagtgt gacaatttct accacaactt caccaaaatc   2520

cccactctgg ttcagatcat caagtcccag atgatgtgtg cggaggacac ccacagggag   2580

aagttctgct atgagctaac tggagagccc ttggtctgct ccatggaggg cacgtggtac   2640

ctggtgggat tggtgagctg gggtgcaggc tgccagaaga gcgaggcccc acccatctac   2700

ctacaggtct cctcctacca acactggatc tgggactgcc tcaacgggca ggccctggcc   2760

ctgccagccc catccaggac cctgctcctg gcactcccac tgcccctcag cctccttgct   2820

gccctctgac tctgtgtgcc ctccctcact tgtgggcccc ccttgcctcc gtgcccaggt   2880

tgctgtgggt gcagctgtca cagccctgag agtcagggtg gagatgaggt gctcaattaa   2940

acattactgt tttccatgcc                                               2960


<210>  9250
<211>  385
<212>  PRT
<213>  Homosapiens

<400>  9250

Met Gly Arg Trp Cys Gln Thr Val Ala Arg Gly Gln Arg Pro Arg Thr 
1               5                   10                  15      


Ser Ala Pro Ser Arg Ala Gly Ala Leu Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Arg Ser Ala Gly Cys Trp Gly Ala Gly Glu Ala Pro Gly Ala Leu Ser 
        35                  40                  45              


Thr Ala Asp Pro Ala Asp Gln Ser Val Gln Cys Val Pro Lys Ala Thr 
    50                  55                  60                  


Cys Pro Ser Ser Arg Pro Arg Leu Leu Trp Gln Thr Pro Thr Thr Gln 
65                  70                  75                  80  


Thr Leu Pro Ser Thr Thr Met Glu Thr Gln Phe Pro Val Ser Glu Gly 
                85                  90                  95      


Lys Val Asp Pro Tyr Arg Ser Cys Gly Phe Ser Tyr Glu Gln Asp Pro 
            100                 105                 110         


Thr Leu Arg Asp Pro Glu Ala Val Ala Arg Arg Trp Pro Trp Met Val 
        115                 120                 125             


Ser Val Arg Ala Asn Gly Thr His Ile Cys Ala Gly Thr Ile Ile Ala 
    130                 135                 140                 


Ser Gln Trp Val Leu Thr Val Ala His Cys Leu Ile Trp Arg Asp Val 
145                 150                 155                 160 


Ile Tyr Ser Val Arg Val Gly Ser Pro Trp Ile Asp Gln Met Thr Gln 
                165                 170                 175     


Thr Ala Ser Asp Val Pro Val Leu Gln Val Ile Met His Ser Arg Tyr 
            180                 185                 190         


Arg Ala Gln Arg Phe Trp Ser Trp Val Gly Gln Ala Asn Asp Ile Gly 
        195                 200                 205             


Leu Leu Lys Leu Lys Gln Glu Leu Lys Tyr Ser Asn Tyr Val Arg Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Thr Asp Tyr Val Leu Lys Asp His Ser Arg Cys 
225                 230                 235                 240 


Thr Val Thr Gly Trp Gly Leu Ser Lys Ala Asp Gly Met Trp Pro Gln 
                245                 250                 255     


Phe Arg Thr Ile Gln Glu Lys Glu Val Ile Ile Leu Asn Asn Lys Glu 
            260                 265                 270         


Cys Asp Asn Phe Tyr His Asn Phe Thr Lys Ile Pro Thr Leu Val Gln 
        275                 280                 285             


Ile Ile Lys Ser Gln Met Met Cys Ala Glu Asp Thr His Arg Glu Lys 
    290                 295                 300                 


Phe Cys Tyr Glu Leu Thr Gly Glu Pro Leu Val Cys Ser Met Glu Gly 
305                 310                 315                 320 


Thr Trp Tyr Leu Val Gly Leu Val Ser Trp Gly Ala Gly Cys Gln Lys 
                325                 330                 335     


Ser Glu Ala Pro Pro Ile Tyr Leu Gln Val Ser Ser Tyr Gln His Trp 
            340                 345                 350         


Ile Trp Asp Cys Leu Asn Gly Gln Ala Leu Ala Leu Pro Ala Pro Ser 
        355                 360                 365             


Arg Thr Leu Leu Leu Ala Leu Pro Leu Pro Leu Ser Leu Leu Ala Ala 
    370                 375                 380                 


Leu 
385 


<210>  9251
<211>  464
<212>  DNA
<213>  Homosapiens

<400>  9251
agcatgtgct gggtaatcgg ctggggaact acagggaaaa aaggttgact ctggaagctc     60

ccttgtctgc caaatggaca agacctggat tcagatagga gtggtaagct ggagctttag    120

ttgtggccag cgccacttcc caggtatcta caccagcact gcccacttca accagtggat    180

caggactgag gttgctaaca taaggttcat cagtagggct ggccctgcct tcctgagccc    240

agttttcctc actggctaca ttctactggg ctccttgagc tccctgtggc tcctgtgagc    300

ggtgtttcaa ggacagtccc tcccagaggc tgcttctccc tcccctctgt tctaccctca    360

gaagtggaga cgagaggttg cccaggatgg cagggcagag tgagggggag ggtccgagag    420

ccactgttac tttctgttgt tcaatgaaga tgcttttgaa cttt                     464


<210>  9252
<211>  74
<212>  PRT
<213>  Homosapiens

<400>  9252

Met Asp Lys Thr Trp Ile Gln Ile Gly Val Val Ser Trp Ser Phe Ser 
1               5                   10                  15      


Cys Gly Gln Arg His Phe Pro Gly Ile Tyr Thr Ser Thr Ala His Phe 
            20                  25                  30          


Asn Gln Trp Ile Arg Thr Glu Val Ala Asn Ile Arg Phe Ile Ser Arg 
        35                  40                  45              


Ala Gly Pro Ala Phe Leu Ser Pro Val Phe Leu Thr Gly Tyr Ile Leu 
    50                  55                  60                  


Leu Gly Ser Leu Ser Ser Leu Trp Leu Leu 
65                  70                  


<210>  9253
<211>  960
<212>  DNA
<213>  Homosapiens

<400>  9253
atggcctgtg ggccggggga tcttcaaagc cttacatctc cgctttcctc tgccagatta     60

gattatcagc cgtctattga agggccctgg ctccgggcct gcggtcagac caacgtgtcc    120

tgcagggtgg tgaaggggaa gctggtagag gtaggcaagt ggccatggca ggtgagcatc    180

cttttcctgg gcacgtacat ctgcagtggc tccctcatcc accaccagtg ggtcctcacg    240

gctgcgcact gcttgcagag attcaaggac ctcagcctgt actccgtgat ggtgggagtc    300

caccagcgcc cagaaaatag cactcagctc ccgctcactc gcatggtgat tcataaggat    360

ttcagcaatc tcatgtctca ggacattgcc ctcctaaagc tcagggactc catctcgtgg    420

tcccccttcg tccagcctgt ctgcctccct aacatcaaat tcaagccatc cattggaagc    480

atgtgctggg taatcggctg gggaactaca gggaaaaaag tgaaggtagt gatggcagtc    540

cttctcagac accgtatgct gggctctggg ccagacatgg ataacactgg gcttaagaaa    600

ggtctgggcc cggggaacaa atggtaccac gtggcacagt ccacacagca caatgcacac    660

aaccttttta ctttttcctc cagggacgct gggctccact ttaaggttga ctctggaagc    720

tcccttgtct gccaaatgga caagacctgg attcagatag gagtggtaag ctggagcttt    780

agttgtggcc agcgccactt cccaggtatc tacaccagca ctgcccactt caaccagtgg    840

atcaggactg aggttgctaa cataaggttc atcagtaggg ctggccctgc cttcctgagc    900

ccagttttcc tcactggcta cattctactg ggctccttga gctccctgtg gctcctgtga    960


<210>  9254
<211>  319
<212>  PRT
<213>  Homosapiens

<400>  9254

Met Ala Cys Gly Pro Gly Asp Leu Gln Ser Leu Thr Ser Pro Leu Ser 
1               5                   10                  15      


Ser Ala Arg Leu Asp Tyr Gln Pro Ser Ile Glu Gly Pro Trp Leu Arg 
            20                  25                  30          


Ala Cys Gly Gln Thr Asn Val Ser Cys Arg Val Val Lys Gly Lys Leu 
        35                  40                  45              


Val Glu Val Gly Lys Trp Pro Trp Gln Val Ser Ile Leu Phe Leu Gly 
    50                  55                  60                  


Thr Tyr Ile Cys Ser Gly Ser Leu Ile His His Gln Trp Val Leu Thr 
65                  70                  75                  80  


Ala Ala His Cys Leu Gln Arg Phe Lys Asp Leu Ser Leu Tyr Ser Val 
                85                  90                  95      


Met Val Gly Val His Gln Arg Pro Glu Asn Ser Thr Gln Leu Pro Leu 
            100                 105                 110         


Thr Arg Met Val Ile His Lys Asp Phe Ser Asn Leu Met Ser Gln Asp 
        115                 120                 125             


Ile Ala Leu Leu Lys Leu Arg Asp Ser Ile Ser Trp Ser Pro Phe Val 
    130                 135                 140                 


Gln Pro Val Cys Leu Pro Asn Ile Lys Phe Lys Pro Ser Ile Gly Ser 
145                 150                 155                 160 


Met Cys Trp Val Ile Gly Trp Gly Thr Thr Gly Lys Lys Val Lys Val 
                165                 170                 175     


Val Met Ala Val Leu Leu Arg His Arg Met Leu Gly Ser Gly Pro Asp 
            180                 185                 190         


Met Asp Asn Thr Gly Leu Lys Lys Gly Leu Gly Pro Gly Asn Lys Trp 
        195                 200                 205             


Tyr His Val Ala Gln Ser Thr Gln His Asn Ala His Asn Leu Phe Thr 
    210                 215                 220                 


Phe Ser Ser Arg Asp Ala Gly Leu His Phe Lys Val Asp Ser Gly Ser 
225                 230                 235                 240 


Ser Leu Val Cys Gln Met Asp Lys Thr Trp Ile Gln Ile Gly Val Val 
                245                 250                 255     


Ser Trp Ser Phe Ser Cys Gly Gln Arg His Phe Pro Gly Ile Tyr Thr 
            260                 265                 270         


Ser Thr Ala His Phe Asn Gln Trp Ile Arg Thr Glu Val Ala Asn Ile 
        275                 280                 285             


Arg Phe Ile Ser Arg Ala Gly Pro Ala Phe Leu Ser Pro Val Phe Leu 
    290                 295                 300                 


Thr Gly Tyr Ile Leu Leu Gly Ser Leu Ser Ser Leu Trp Leu Leu 
305                 310                 315                 


<210>  9255
<211>  1041
<212>  DNA
<213>  Homosapiens

<400>  9255
atgacccgcc attggccctg ggaggtgagc ctccggatgg aaaatgagca cgtgtgtgga     60

ggggccctca ttgaccccag ctgggtggtg actgcggccc actgcatcca aggcaccaaa    120

gagtactcag tggtgcttgg cacctccaag ctgcagccca tgaacttcag cagggccctc    180

tgggtccctg tgagggacat cattatgcac cccaagtact ggggccgggc cttcatcatg    240

ggtgacgttg cccttgtcca ccttcaaaca cctgtcacct tcagtgagta cgtgcagccc    300

atctgcctcc cggagcccaa tttcaacctg aaggttggga cgcagtgttg ggtgactggc    360

tggagccagg ttaagcagcg cttttcagcc aactccatgc tgaccccaga gctgcaggag    420

gctgaggtgt ttatcatgga caacaagagg tgtgaccggc attacaagaa gtccttcttc    480

cccccagttg tcccccttgt cctgggggac atgatctgtg ccaccaatta tggggaaaac    540

ttgtgctatg gggattctgg agggccattg gcttgtgaag ttgagggcag atggattctg    600

gctggggtgt tgtcctggga aaaggcctgc gtgaaggcac agaatccagg tgtgtacacc    660

cgcatcacca aatacaccaa atggatcaag aagcaaatga gcaatggagc cttctcaggt    720

ccctgtgcct ctgcctgcct cctgttcctg tgctggctgc tgcagcccca gatgggctcc    780

tgacctccct accttttcct cctcctgcct tgcctctgct gaatggggcc agatggtttg    840

accaaggtca tgtgtccatc ttcaaaaaga gtcagggtgg ggaagagtaa cccctgggag    900

aatgggtctg gctttggcat cccggtgagg agaagtgtgg tggatgacta ggccttgggt    960

gagcaggaga agggaagtgt ggcctagaag gattctggaa tctgggacca ggagagcagg   1020

gattaaacat gtgcaaactt g                                             1041


<210>  9256
<211>  260
<212>  PRT
<213>  Homosapiens

<400>  9256

Met Thr Arg His Trp Pro Trp Glu Val Ser Leu Arg Met Glu Asn Glu 
1               5                   10                  15      


His Val Cys Gly Gly Ala Leu Ile Asp Pro Ser Trp Val Val Thr Ala 
            20                  25                  30          


Ala His Cys Ile Gln Gly Thr Lys Glu Tyr Ser Val Val Leu Gly Thr 
        35                  40                  45              


Ser Lys Leu Gln Pro Met Asn Phe Ser Arg Ala Leu Trp Val Pro Val 
    50                  55                  60                  


Arg Asp Ile Ile Met His Pro Lys Tyr Trp Gly Arg Ala Phe Ile Met 
65                  70                  75                  80  


Gly Asp Val Ala Leu Val His Leu Gln Thr Pro Val Thr Phe Ser Glu 
                85                  90                  95      


Tyr Val Gln Pro Ile Cys Leu Pro Glu Pro Asn Phe Asn Leu Lys Val 
            100                 105                 110         


Gly Thr Gln Cys Trp Val Thr Gly Trp Ser Gln Val Lys Gln Arg Phe 
        115                 120                 125             


Ser Ala Asn Ser Met Leu Thr Pro Glu Leu Gln Glu Ala Glu Val Phe 
    130                 135                 140                 


Ile Met Asp Asn Lys Arg Cys Asp Arg His Tyr Lys Lys Ser Phe Phe 
145                 150                 155                 160 


Pro Pro Val Val Pro Leu Val Leu Gly Asp Met Ile Cys Ala Thr Asn 
                165                 170                 175     


Tyr Gly Glu Asn Leu Cys Tyr Gly Asp Ser Gly Gly Pro Leu Ala Cys 
            180                 185                 190         


Glu Val Glu Gly Arg Trp Ile Leu Ala Gly Val Leu Ser Trp Glu Lys 
        195                 200                 205             


Ala Cys Val Lys Ala Gln Asn Pro Gly Val Tyr Thr Arg Ile Thr Lys 
    210                 215                 220                 


Tyr Thr Lys Trp Ile Lys Lys Gln Met Ser Asn Gly Ala Phe Ser Gly 
225                 230                 235                 240 


Pro Cys Ala Ser Ala Cys Leu Leu Phe Leu Cys Trp Leu Leu Gln Pro 
                245                 250                 255     


Gln Met Gly Ser 
            260 


<210>  9257
<211>  3128
<212>  DNA
<213>  Homosapiens

<400>  9257
agaacccatg gccggcgtgg aaaccgctgc gaggcggcgc cacgacggag gctgaggtcg     60

ccggcagtat ccatggcgtc ccagagcggc agctccctgg ggctcctggc ctggttcttg    120

cttcttcagc catggctcga agaggcccgg gcaggcaggg tgggtgcgca gggaggcgta    180

gcactgctct tcccctccgc gctcccctca gggccaggcg gccaggaccc cggagcgagc    240

ggatgggagc cgccacctgt aggggctcca ggatccccag cggcccccca gtccaggggg    300

aacgcagtgc gccccgcttc ggtgttactt ccctcagcct gtggccagcg gacttcaagg    360

ataactggag gattgccggc tccagacagg aagtggccct ggcaggtgag cctgcagacc    420

agcaacagac acatctgcgg aggctccctt atcgccagac actgggtact cactgccgct    480

cactgcatct ctgggtgagg gtttggggct cagagcttgg gccctgatca ggctgtggga    540

cctggagcca gtctgtcccc ctccctgaac ttcctcttcc tcatctgtaa aagggggtga    600

cagccccata gtttttatcc agtctgggtg agacctgagg atttgcattt ctaacaagtt    660

tctgggtgtt gcctccgccg ctgatctggg gactactggc taaagtggtc aggggtcctg    720

gagggatgtg gcttggagag agggaggtag ctgctggctg gcataggaag atggtaccag    780

gcgggaagca cctcgaaggt gtggaagcag agtgtagacc ctggaggatc ttcctgcagc    840

catctggaat acacagtgaa gctgggagac acaaatgtgc atcatcgctc caaaacagca    900

cttgtggtcc cagttcgtga cgtcgttatc caccgatatt ttacgtctcc tggaataatt    960

gaaaatgaca ttgcccttgc cctgcttgac ttccctgtga attactccac gcacatccag   1020

cttgtgtgcc tccctgaaca ggctttcatg gtgcaagctg gtacgaactg ctgggtgacc   1080

ggatggggca aagtaaatga aacaggtgag ccataccgac ccgaggagga ttccagaatg   1140

accccggcaa gcccagaagc ccggacgtct cctgtgcacc cgaaattccc caaaattcca   1200

gaaacttctg tagctccagg gtctccagcg accgcagggc ctccaggatc ctgggttact   1260

tcagcatcta cagtgggaga agccttggaa tccgacggaa tctctgacct tggaaggcag   1320

ttttctcagg gtattgtttc tggtgctaga tctgtcctgg cctgcggggt aggtcaaagg   1380

ggacacagcc tggctcaggg aggttgaggg tcagaccctg acctagatga tttgagagag   1440

aggatagata acccgcctcc gccctgggca gcctggtggg gtggtgggaa ggtagtggct   1500

tcacttccag tcccctctct ttactgagcc caccagcctg tggccaccgt gtttcaagga   1560

tgattggagg attgccagcc ccaaacaaga agtggccctg gcaggtgagc ctgcagacca   1620

gcaacataca ccactgcgga ggctccctca tcgacaggcg ctgggtgctc actgccgccc   1680

actgtgtctt tagtaatttg gaatacaagg tgaagctggg agaccctgac ttgcatgctg   1740

gttccaaaga ggcactggtg atcccagttt gagacatcat ttttcctagc aattttgatt   1800

ttgccacttt gacaagcgac attgcccttg ctctgctcgc ctactctgtg aattattcct   1860

cacatatcca gcctgcgtgc ctccccgaaa agctttttga agtggaagct gggacagagt   1920

gctgggtgac tggatggggc caagtgtcag agagtgtttc aggaccaatg ccacttgttc   1980

ttcaggagac tgagctaaac attatgcgtc atgagaaatg ttgtgagatg ctcaagaaca   2040

agaatatatc caagagtaaa atggtcacga gggggaccgt ctgtggctat aatgaccaag   2100

ggaaggatgc ctgtcaggtt ataaagagga cacaaccaat ccagtttgtg gtgagccctg   2160

gtggtcggag gatttggaaa tgacccgcca ttggccctgg gaggtgagcc tccggatgga   2220

aaatgagcac gtgtgtggag gggccctcat tgaccccagc tgggtggtga ctgcggccca   2280

ctgcatccaa ggcaccaaag agtactcagt ggtgcttggc acctccaagc tgcagcccat   2340

gaacttcagc agggccctct gggtccctgt gagggacatc attatgcacc ccaagtactg   2400

gggccgggcc ttcatcatgg gtgacgttgc ccttgtccac cttcaaacac ctgtcacctt   2460

cagtgagctc cacagccaac tccatgctga ccccagagct gcaggaggct gaggtgttta   2520

tcatggacaa caagaggtgt gaccggcatt acaagaagtc cttcttcccc ccagttgtcc   2580

cccttgtcct gggggacatg atctgtgcca ccaattatgg ggaaaacttg tgctatgggg   2640

attctggagg gccattggct tgtgaagttg agggcagatg gattctggct ggggtgttgt   2700

cctgggaaaa ggcctgcgtg aaggcacaga atccaggtgt gtacacccgc atcaccaaat   2760

acaccaaatg gatcaagaag caaatgagca atggagcctt ctcaggtccc tgtgcctctg   2820

cctgcctcct gttcctgtgc tggctgctgc agccccagat gggctcctga cctccctacc   2880

ttttcctcct cctgccttgc ctctgctgaa tggggccaga tggtttgacc aaggtcatgt   2940

gtccatcttc aaaaagagtc agggtgggga agagtaaccc ctgggagaat gggtctggct   3000

ttggcatccc ggtgaggaga agtgtggtgg atgactaggc cttgggtgag caggagaagg   3060

gaagtgtggc ctagaaggat tctggaatct gggaccagga gagcagggat taaacatgtg   3120

caaacttg                                                            3128


<210>  9258
<211>  141
<212>  PRT
<213>  Homosapiens

<400>  9258

Met Ala Ser Gln Ser Gly Ser Ser Leu Gly Leu Leu Ala Trp Phe Leu 
1               5                   10                  15      


Leu Leu Gln Pro Trp Leu Glu Glu Ala Arg Ala Gly Arg Val Gly Ala 
            20                  25                  30          


Gln Gly Gly Val Ala Leu Leu Phe Pro Ser Ala Leu Pro Ser Gly Pro 
        35                  40                  45              


Gly Gly Gln Asp Pro Gly Ala Ser Gly Trp Glu Pro Pro Pro Val Gly 
    50                  55                  60                  


Ala Pro Gly Ser Pro Ala Ala Pro Gln Ser Arg Gly Asn Ala Val Arg 
65                  70                  75                  80  


Pro Ala Ser Val Leu Leu Pro Ser Ala Cys Gly Gln Arg Thr Ser Arg 
                85                  90                  95      


Ile Thr Gly Gly Leu Pro Ala Pro Asp Arg Lys Trp Pro Trp Gln Val 
            100                 105                 110         


Ser Leu Gln Thr Ser Asn Arg His Ile Cys Gly Gly Ser Leu Ile Ala 
        115                 120                 125             


Arg His Trp Val Leu Thr Ala Ala His Cys Ile Ser Gly 
    130                 135                 140     


<210>  9259
<211>  492
<212>  DNA
<213>  Homosapiens

<400>  9259
ctccgccgct gatctgggga ctactggcta aagtggtcag gggtcctgga gggatgtggc     60

ttggagagag ggaggtagct gctggctggc ataggaagat ggtaccaggc gggaagcacc    120

tcgaaggtgt ggaagcagag tgtagaccct ggaggatctt cctgcagcca tctggaatac    180

acagtgaagc tgggagacac aaatgtgcat catcgctcca aaacagcact tgtggtccca    240

gttcgtgacg tcgttatcca ccgatatttt acgtctcctg gaataattga aaatgacatt    300

gcccttgccc tgcttgactt ccctgtgaat tactccacgc acatccagct tgtgtgcctc    360

cctgaacagg ctttcatggt gcaagctggt acgaactgct gggtgaccgg atggggcaaa    420

gtaaatgaaa cagattctca aaccaagagt aattgtgaaa ctctccagtg cgctgggacc    480

agggaaccaa gg                                                        492


<210>  9260
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  9260

Met Val Gln Ala Gly Thr Asn Cys Trp Val Thr Gly Trp Gly Lys Val 
1               5                   10                  15      


Asn Glu Thr Asp Ser Gln Thr Lys Ser Asn Cys Glu Thr Leu Gln Cys 
            20                  25                  30          


Ala Gly Thr Arg Glu Pro 
        35              


<210>  9261
<211>  1447
<212>  DNA
<213>  Homosapiens

<400>  9261
atgggagccg ccacctgtag gggctccagg atccccagcg gccccccagt ccagggggaa     60

cgcagtgcgc cccgcttcgg tgttacttcc ctcagcctgt ggccagcgga cttcaaggat    120

aactggagga ttgccggctc cagacaggaa gtggccctgg cagcacttgt ggtcccagtt    180

cgtgacgtcg ttatccaccg atattttacg tctcctggaa taattgaaaa tgacattgcc    240

cttgccctgc ttgacttccc tgtgaattac tccacgcaca tccagcttgt gtgcctccct    300

gaacaggctt tcatggtgca agctggtacg aactgctggg tgaccggatg gggcaaagta    360

aatgaaacag attcatcaga aaagatagta actgagcctc aggaggctga gctaagcatt    420

attcttcatg ataaatgtaa tgaggtgctc aaggaaaaga taagaatgag gagtgaaatg    480

gtcaagaaag ggaccatctg tggctataat gaccaaggga aggatgcctg tcagggagat    540

tctggggggc ccctggtctg tgaattaaat ggcacatggg tccaggttgc cttcgtgaag    600

gggggaaaaa acacaactgg cctggtgggg tggtgggaag gtagtggctt cacttccagt    660

cccctctctt tactgagccc accagcctgt ggccaccgtg tttcaaggat gattggagga    720

ttgccagccc caaacaagaa gtggccctgg caggtgagcc tgcagaccag caacatacac    780

cactgcggag gctccctcat cgacaggcgc tgggtgctca ctgccgccca ctgtgtcttt    840

agtaatttgg aatacaaggt gaagctggga gaccctgact tgcatgctgg ttccaaagag    900

gcactggtga tcccagtttg agacatcatt tttcctagca attttgattt tgccactttg    960

acaagcgaca ttgcccttgc tctgctcgcc tactctgtga attattcctc acatatccag   1020

cctgcgtgcc tccccgaaaa gctttttgaa gtggaagctg ggacagagtg ctgggtgact   1080

ggatggggcc aagtgtcaga gagtggtgag acaggcagga tgctgaggtg ggacagtctg   1140

gtgggctggg cttggcctgc aagctattgg gagaggcagg gaggccattt tctagcaggt   1200

gggtgaggga ggagggtgga gaagatgctg ccaggaagta atttaacaac tatgttatga   1260

atttctgtcg tcatattggg accttggggc ttgggggcca agtgtagtgg gttctcttca   1320

gggtaaattt cagctcaggg tgatgagctg tctgccaata ggagccaacc cccactagaa   1380

ggacctgcct tgatgggttg aacttcttca ccctagcagt gtaggccaag ccagagcaac   1440

cctgcca                                                             1447


<210>  9262
<211>  306
<212>  PRT
<213>  Homosapiens

<400>  9262

Met Gly Ala Ala Thr Cys Arg Gly Ser Arg Ile Pro Ser Gly Pro Pro 
1               5                   10                  15      


Val Gln Gly Glu Arg Ser Ala Pro Arg Phe Gly Val Thr Ser Leu Ser 
            20                  25                  30          


Leu Trp Pro Ala Asp Phe Lys Asp Asn Trp Arg Ile Ala Gly Ser Arg 
        35                  40                  45              


Gln Glu Val Ala Leu Ala Ala Leu Val Val Pro Val Arg Asp Val Val 
    50                  55                  60                  


Ile His Arg Tyr Phe Thr Ser Pro Gly Ile Ile Glu Asn Asp Ile Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp Phe Pro Val Asn Tyr Ser Thr His Ile Gln Leu 
                85                  90                  95      


Val Cys Leu Pro Glu Gln Ala Phe Met Val Gln Ala Gly Thr Asn Cys 
            100                 105                 110         


Trp Val Thr Gly Trp Gly Lys Val Asn Glu Thr Asp Ser Ser Glu Lys 
        115                 120                 125             


Ile Val Thr Glu Pro Gln Glu Ala Glu Leu Ser Ile Ile Leu His Asp 
    130                 135                 140                 


Lys Cys Asn Glu Val Leu Lys Glu Lys Ile Arg Met Arg Ser Glu Met 
145                 150                 155                 160 


Val Lys Lys Gly Thr Ile Cys Gly Tyr Asn Asp Gln Gly Lys Asp Ala 
                165                 170                 175     


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Leu Asn Gly Thr 
            180                 185                 190         


Trp Val Gln Val Ala Phe Val Lys Gly Gly Lys Asn Thr Thr Gly Leu 
        195                 200                 205             


Val Gly Trp Trp Glu Gly Ser Gly Phe Thr Ser Ser Pro Leu Ser Leu 
    210                 215                 220                 


Leu Ser Pro Pro Ala Cys Gly His Arg Val Ser Arg Met Ile Gly Gly 
225                 230                 235                 240 


Leu Pro Ala Pro Asn Lys Lys Trp Pro Trp Gln Val Ser Leu Gln Thr 
                245                 250                 255     


Ser Asn Ile His His Cys Gly Gly Ser Leu Ile Asp Arg Arg Trp Val 
            260                 265                 270         


Leu Thr Ala Ala His Cys Val Phe Ser Asn Leu Glu Tyr Lys Val Lys 
        275                 280                 285             


Leu Gly Asp Pro Asp Leu His Ala Gly Ser Lys Glu Ala Leu Val Ile 
    290                 295                 300                 


Pro Val 
305     


<210>  9263
<211>  302
<212>  DNA
<213>  Homosapiens

<400>  9263
gctgggcatg gcccagaagc gtcacctgac gtttaatgct actgtccctt tggtccatgt     60

tgatgatagt gtgtgtggga ttgccagagc ctgctctccg tggactcagg gccctccacc    120

tcatcgggag cctcccaggc actcagcgtc tcctggccta gggccctcgc ctcagagtgg    180

cagctgtcta gccctttgtt cacacaaaaa tgcgaccact actctacggc agagcttcct    240

ccagccaggg ctttagagtc tccttccctt acttgtttgc aataaaaatt aaaactcttt    300

aa                                                                   302


<210>  9264
<211>  82
<212>  PRT
<213>  Homosapiens

<400>  9264

Met Ala Gln Lys Arg His Leu Thr Phe Asn Ala Thr Val Pro Leu Val 
1               5                   10                  15      


His Val Asp Asp Ser Val Cys Gly Ile Ala Arg Ala Cys Ser Pro Trp 
            20                  25                  30          


Thr Gln Gly Pro Pro Pro His Arg Glu Pro Pro Arg His Ser Ala Ser 
        35                  40                  45              


Pro Gly Leu Gly Pro Ser Pro Gln Ser Gly Ser Cys Leu Ala Leu Cys 
    50                  55                  60                  


Ser His Lys Asn Ala Thr Thr Thr Leu Arg Gln Ser Phe Leu Gln Pro 
65                  70                  75                  80  


Gly Leu 
        


<210>  9265
<211>  1827
<212>  DNA
<213>  Homosapiens

<400>  9265
agcctgcggt ccgcggcccg gggaatctga agcgtggctc gggagccccg ggggacatgg     60

cctccttctt ggctgtcgtc ggggcgcccg ggggagtcaa ctcctgtgtc tttgaccgtt    120

tccattacag tgtcaagatg ggagatcgga gtgtctataa tgaaaacaca agtgtggtgg    180

tctcagtcca aagagctttt gtccacccta agttctcaac agttacaacc attcgaaatg    240

accttgccct tctccagctc caacatcctg tgaattttac ctcaaacatc cagcctatct    300

gcatccctca ggagaatttc caggtggaag ggagattctg ggggccgctt ggcctgtgaa    360

tataatgaca catgggtcca ggtagggatt gtgagctggg gcatcggctg tggtcgctga    420

gggttgcctg gagtttatac agaaattggt gtctacagta agtggctgat tgcagtggtg    480

gatcaggcta cctgtttgta tccagcagtg ttcctcatct tagtcctgca tttggtgctg    540

cccctgggca tcctggtggc ccagtgatca ccccagccca ctcccctttt gtttctgagt    600

ctcatactag gcctctcctc caacctccca ctccttctca atgccgtttc tgaaaatccc    660

agttggaatc cacgggccct ctggagatcc atacaataga gcacagcagg gagactgggg    720

cctggaaagt gcccctgcct ggtgctctgg tcacctgcct cagccatgcc tgcaccaggg    780

ctgtgctctg gctagtggga aggagggggt gaactaattc cagctagagg accagcctcc    840

ctgccaggtg ggccacagtg actcatcagt atctggggga acatctatca aagaagagac    900

atcatcaaca gtgaagcaag tgttagatgt ggttctggtt tcagggctcc cacctaagac    960

tttgtgaaac cagccagctg ggtgattgct cagcgtgaag gaggcgttac caggtccctg   1020

cagaggtgtg aggcctggga cttccactct aggctcagtt gtctggggct gggagaagtt   1080

cccctgcagc ccagtgtgga tccatctgtg agtggacagc ctctgccaca ctaactctct   1140

tggggctacc cattcttggc acccccttcc tcagtgccct agtggccact ttcagagaca   1200

ctacaagttg tattgaggca gttatggagt gcagagtttt cagaaatcaa ctaaataaat   1260

gtttggagag tctcctatgt tctccatgtc tactggcctg gttattgggg acactgaaga   1320

caacttacct cacattaagc ttaggaagat gttgatgatt ctttttaaac taaagagtga   1380

gagaggaagt ctctgcctgc ccagttgtga gttggatgga tggttttaga cagttgggtt   1440

ttgctgccta tgctctccat ggccatcagc atttccgcat ggagctttgt agctgagttt   1500

gctagtcatt gcatctggga aggaggaagc gagagaaact ggaagcaaga gagtggtcag   1560

ggcactacac cccaaactgc aacctccatt ttctgcctat ttctgcccct ccttctccaa   1620

gccttgagca ccagatcact ttaatcaggc tctatggaaa acacagggct gagggttagg   1680

gagatgacag gttggggtgc ttactgattc tggctcattt ccctcattac cctatgggtc   1740

ccagggtagt tctttgatat gatgcagagc ccattattgc ttccagtttc cttctttgtt   1800

tatgaaacat tgaagttgcc tcctttt                                       1827


<210>  9266
<211>  100
<212>  PRT
<213>  Homosapiens

<400>  9266

Met Ala Ser Phe Leu Ala Val Val Gly Ala Pro Gly Gly Val Asn Ser 
1               5                   10                  15      


Cys Val Phe Asp Arg Phe His Tyr Ser Val Lys Met Gly Asp Arg Ser 
            20                  25                  30          


Val Tyr Asn Glu Asn Thr Ser Val Val Val Ser Val Gln Arg Ala Phe 
        35                  40                  45              


Val His Pro Lys Phe Ser Thr Val Thr Thr Ile Arg Asn Asp Leu Ala 
    50                  55                  60                  


Leu Leu Gln Leu Gln His Pro Val Asn Phe Thr Ser Asn Ile Gln Pro 
65                  70                  75                  80  


Ile Cys Ile Pro Gln Glu Asn Phe Gln Val Glu Gly Arg Phe Trp Gly 
                85                  90                  95      


Pro Leu Gly Leu 
            100 


<210>  9267
<211>  882
<212>  DNA
<213>  Homosapiens

<400>  9267
atgtcctctg gcggcggctc ccggggcctc ctggcgtggc ttctgctcct tcagccctgg     60

cccgggcaga actgggcggg catggcggcg ccacgcctcc cgtcccctct cctctcagag    120

gagggcggcg agaaccccga agcgagcccg gctccaggac ctgaagcggg ccccccactc    180

aatctgttta cgtcctttcc aggtgactca ctgctgtgtg gccgaacccc tctgagaatc    240

gtgggaggag tggacgcgga ggaagggagg tggccctggc aggtgagcgt gaggaccaaa    300

ggcaggcaca tctgcggcgg caccctggtc accgccacgt gggtgctgac ggcaggccac    360

tgcatttcca gccgtttcca ttacagtgtc aagatgggag atcggagtgt ctataatgaa    420

aacacaagtg tggtggtctc agtccaaaga gcttttgtcc accctaagtt ctcaacagtt    480

acaaccattc gaaatgacct tgcccttctc cagctccaac atcctgtgaa ttttacctca    540

aacatccagc ctatctgcat ccctcaggag aatttccagg tggaaggtag gaccaggtgc    600

tgggtgaccg gatggggcaa aacaccagaa cgagagaaac ttgcatcaga aattcttcag    660

gatgtggacc aatacatcat gtgctatgag gaatgtaata agataataca gaaggccttg    720

tcatctacta aggatgtaat aataaaaggg atggtctgtg gctataaaga acaaggaaag    780

gattcttgtc aaggagattc tgggggccgc ttggcctgtg aatataatga cacatgggtc    840

caggtaggga ttgtgagctg gggcatcggc tgtggtcgct ga                       882


<210>  9268
<211>  293
<212>  PRT
<213>  Homosapiens

<400>  9268

Met Ser Ser Gly Gly Gly Ser Arg Gly Leu Leu Ala Trp Leu Leu Leu 
1               5                   10                  15      


Leu Gln Pro Trp Pro Gly Gln Asn Trp Ala Gly Met Ala Ala Pro Arg 
            20                  25                  30          


Leu Pro Ser Pro Leu Leu Ser Glu Glu Gly Gly Glu Asn Pro Glu Ala 
        35                  40                  45              


Ser Pro Ala Pro Gly Pro Glu Ala Gly Pro Pro Leu Asn Leu Phe Thr 
    50                  55                  60                  


Ser Phe Pro Gly Asp Ser Leu Leu Cys Gly Arg Thr Pro Leu Arg Ile 
65                  70                  75                  80  


Val Gly Gly Val Asp Ala Glu Glu Gly Arg Trp Pro Trp Gln Val Ser 
                85                  90                  95      


Val Arg Thr Lys Gly Arg His Ile Cys Gly Gly Thr Leu Val Thr Ala 
            100                 105                 110         


Thr Trp Val Leu Thr Ala Gly His Cys Ile Ser Ser Arg Phe His Tyr 
        115                 120                 125             


Ser Val Lys Met Gly Asp Arg Ser Val Tyr Asn Glu Asn Thr Ser Val 
    130                 135                 140                 


Val Val Ser Val Gln Arg Ala Phe Val His Pro Lys Phe Ser Thr Val 
145                 150                 155                 160 


Thr Thr Ile Arg Asn Asp Leu Ala Leu Leu Gln Leu Gln His Pro Val 
                165                 170                 175     


Asn Phe Thr Ser Asn Ile Gln Pro Ile Cys Ile Pro Gln Glu Asn Phe 
            180                 185                 190         


Gln Val Glu Gly Arg Thr Arg Cys Trp Val Thr Gly Trp Gly Lys Thr 
        195                 200                 205             


Pro Glu Arg Glu Lys Leu Ala Ser Glu Ile Leu Gln Asp Val Asp Gln 
    210                 215                 220                 


Tyr Ile Met Cys Tyr Glu Glu Cys Asn Lys Ile Ile Gln Lys Ala Leu 
225                 230                 235                 240 


Ser Ser Thr Lys Asp Val Ile Ile Lys Gly Met Val Cys Gly Tyr Lys 
                245                 250                 255     


Glu Gln Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Arg Leu Ala 
            260                 265                 270         


Cys Glu Tyr Asn Asp Thr Trp Val Gln Val Gly Ile Val Ser Trp Gly 
        275                 280                 285             


Ile Gly Cys Gly Arg 
    290             


<210>  9269
<211>  907
<212>  DNA
<213>  Homosapiens

<400>  9269
ggcggctcac ctaccctgct ttctgcattc ttctctccac atccctctct gtacttacag     60

cccccaatgg cccccaaaaa gccagagccc aagaaggatg atgccaaggc agcccccaag    120

gcagctccag ctcccgcacc tccccctgag cctgagcgcc ctaaggaggt cgagtttgat    180

gcttccaaga tcaagattga gttcacacct gagcagattg aagagttcaa ggaagccttc    240

atgctgttcg accgcacacc caagtgtgag atgaagatca cctacgggca gtgtggggat    300

gtcctgcggg cgctgggcca gaaccccaca caggcagaag tgctccgtgt cctggggaag    360

ccaagacagg aagagctcaa taccaagatg atggactttg aaactttcct gcctatgctc    420

cagcacattt ccaagaacaa ggacacaggc acctatgagg acttcgtgga ggggctgcgg    480

gtcttcgaca aggagggcaa tggcactgtc atgggtgctg agcttcgcca cgtgctggcc    540

acgctgggtg agaggctgac agaagacgaa gtggagaagt tgatggctgg gcaagaggac    600

tccaatggct gcatcaacta tgaagcattt gtgaagcaca tcatgtccag ctaaacctcg    660

tgcccaggaa gcccagggaa ggctgtgcag ggacgtctca tctcccatgt gtgatgctga    720

caccagcggc ctggagtcgt gggaaggagg ggagccttac caagactcct gcaaaaaccc    780

ttggacctct ccacgtggtt gccgtctctg gcccctctca ggctgtgctt acctgtgaca    840

gcagctctgt ccccacccca tgggcctcat gaataaatgg cttcttgccg gccttccttt    900

ctgactt                                                              907


<210>  9270
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  9270

Met Ala Pro Lys Lys Pro Glu Pro Lys Lys Asp Asp Ala Lys Ala Ala 
1               5                   10                  15      


Pro Lys Ala Ala Pro Ala Pro Ala Pro Pro Pro Glu Pro Glu Arg Pro 
            20                  25                  30          


Lys Glu Val Glu Phe Asp Ala Ser Lys Ile Lys Ile Glu Phe Thr Pro 
        35                  40                  45              


Glu Gln Ile Glu Glu Phe Lys Glu Ala Phe Met Leu Phe Asp Arg Thr 
    50                  55                  60                  


Pro Lys Cys Glu Met Lys Ile Thr Tyr Gly Gln Cys Gly Asp Val Leu 
65                  70                  75                  80  


Arg Ala Leu Gly Gln Asn Pro Thr Gln Ala Glu Val Leu Arg Val Leu 
                85                  90                  95      


Gly Lys Pro Arg Gln Glu Glu Leu Asn Thr Lys Met Met Asp Phe Glu 
            100                 105                 110         


Thr Phe Leu Pro Met Leu Gln His Ile Ser Lys Asn Lys Asp Thr Gly 
        115                 120                 125             


Thr Tyr Glu Asp Phe Val Glu Gly Leu Arg Val Phe Asp Lys Glu Gly 
    130                 135                 140                 


Asn Gly Thr Val Met Gly Ala Glu Leu Arg His Val Leu Ala Thr Leu 
145                 150                 155                 160 


Gly Glu Arg Leu Thr Glu Asp Glu Val Glu Lys Leu Met Ala Gly Gln 
                165                 170                 175     


Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe Val Lys His Ile 
            180                 185                 190         


Met Ser Ser 
        195 


<210>  9271
<211>  442
<212>  DNA
<213>  Homosapiens

<400>  9271
gacgcgggag tgtggagagg ccgagaggag ccttccgccc cccgccccgg gacattgcgc     60

tagaggccga ggcccggagt cttacggcgg cgggatgtcc tgggaaaatg tagctgtgga    120

agagcagaac attcctccct cctgtgatgg ctgacattca taggaaggcg gacacacgga    180

agacgccagg taacaagagc ccagaagaag gccggcgtgg ccgggctttc ctgccttagt    240

ccacaggctc ctcagaagtc agggcccata tcttccccgc attctccttg gctgggggaa    300

gggagagccc ccaatggccc ccaaaaagcc agagcccaag aaggatgatg ccaaggcagc    360

ccccaaggca gctccagctc ccgcacctcc ccctgagcct gagcgcccta aggaggtcga    420

gtttgatgct tccaagatca ag                                             442


<210>  9272
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  9272

Met Ala Pro Lys Lys Pro Glu Pro Lys Lys Asp Asp Ala Lys Ala Ala 
1               5                   10                  15      


Pro Lys Ala Ala Pro Ala Pro Ala Pro Pro Pro Glu Pro Glu Arg Pro 
            20                  25                  30          


Lys Glu Val Glu Phe Asp Ala Ser Lys Ile 
        35                  40          


<210>  9273
<211>  669
<212>  DNA
<213>  Homosapiens

<400>  9273
aggggcagga aaacaaggag aaaccatcat tgattgcggc tgccagaagc cgtcaccacc     60

tctcaggccc ctcctcgcct gaccttgggg tccagagaga ggacatgcca gtctccccac    120

tcccatggtc tcacagcagc agctgcaggg acagccaggc tggtctggga tgggggtcga    180

gggtgggtcc tctctgccag ctccaggttc agctgctgtc tcagggttag gctccagctc    240

aacccctggg gctgctccct ggctttctga gaagatgccg tcaggcagat tccatctcat    300

aacgtttcct ggaggaaaac gttccgacaa tgagcgttcc aacaatgaag ggatctgtct    360

ctgatcctgg ggcctgctca tgaggaaact gagcctaccc atggcaactg agagacaaag    420

agggaccacg ggacggtgct ctaactcacc caaagaaagc acagagatgg gcacaaaggt    480

aacaacacgc aacactgagg gatgcagacc tgagggcccc atccctcagc atccaatccc    540

agtgcttccc cttccggtga agacctcctg ctgaacagat gaggaacaga ccagagactt    600

gccctactcc agtgggatgc aagcccatgc ccacactgcc agggagtgga ctgtcaacaa    660

cccaaggcc                                                            669


<210>  9274
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  9274

Met Arg Lys Leu Ser Leu Pro Met Ala Thr Glu Arg Gln Arg Gly Thr 
1               5                   10                  15      


Thr Gly Arg Cys Ser Asn Ser Pro Lys Glu Ser Thr Glu Met Gly Thr 
            20                  25                  30          


Lys Val Thr Thr Arg Asn Thr Glu Gly Cys Arg Pro Glu Gly Pro Ile 
        35                  40                  45              


Pro Gln His Pro Ile Pro Val Leu Pro Leu Pro Val Lys Thr Ser Cys 
    50                  55                  60                  


<210>  9275
<211>  2135
<212>  DNA
<213>  Homosapiens

<400>  9275
ggcctgagcc acagaagctg ctcagggact atccatggcc tccccgtggc caacttgagt     60

ctgctctgca gctttaggcc cgacttggaa ggcccatggg ctgcagatga ggaaactgag    120

gtccagacag ccgaagagtg gtagtgtcca ggacacacaa ctgggccggc ggcggcggct    180

gccccgaggg acgcggccct aggcggtggc gatggggacc gcccggatcg cacccggcct    240

ggcgctcctg ctctgctgcc ccgtgctcag ctccgcgtac gcgctggtgg atgcagatga    300

cgtcatgact aaagaggaac agatcttcct gctgcaccgt gctcaggccc agtgcgaaaa    360

acggctcaag gaggtcctgc agaggccagc cagcataatg gaatcagaca agggatggac    420

atctgcgtcc acatcaggga agcccaggaa agataaggca tctgggaagc tctaccctga    480

gtctgaggag gacaaggagg cacccactgg cagcaggtac cgagggcgcc cctgtctgcc    540

ggaatgggac cacatcctgt gctggccgct gggggcacca ggtgaggtgg tggctgtgcc    600

ctgtccggac tacatttatg acttcaatca caaaggccat gcctaccgac gctgtgaccg    660

caatggcagc tgggagctgg tgcctgggca caacaggacg tgggccaact acagcgagtg    720

tgtcaaattt ctcaccaatg agactcgtga acgggaggtg tttgaccgcc tgggcatgat    780

ttacaccgtg ggctactccg tgtccctggc gtccctcacc gtagctgtgc tcatcctggc    840

ctactttagg cggctgcact gcacgcgcaa ctacatccac atgcacctgt tcctgtcctt    900

catgctgcgc gccgtgagca tcttcgtcaa ggacgctgtg ctctactctg gcgccacgct    960

tgatgaggct gagcgcctca ccgaggagga gctgcgcgcc atcgcccagg cgcccccgcc   1020

gcctgccacc gccgctgccg gctacgcggg ctgcagggtg gctgtgacct tcttccttta   1080

cttcctggcc accaactact actggattct ggtggagggg ctgtacctgc acagcctcat   1140

cttcatggcc ttcttctcag agaagaagta cctgtggggc ttcacagtct tcggctgggg   1200

tctgcccgct gtcttcgtgg ctgtgtgggt cagtgtcaga gctaccctgg ccaacaccgg   1260

gtgctgggac ttgagctccg ggaacaaaaa gtggatcatc caggtgccca tcctggcctc   1320

cattgtgctc aacttcatcc tcttcatcaa tatcgtccgg gtgctcgcca ccaagctgcg   1380

ggagaccaac gccggccggt gtgacacacg gcagcagtac cggaagctgc tcaaatccac   1440

gctggtgctc atgcccctct ttggcgtcca ctacattgtc ttcatggcca caccatacac   1500

cgaggtctca gggacgctct ggcaagtcca gatgcactat gagatgctct tcaactcctt   1560

ccagggattt tttgtcgcaa tcatatactg tttctgcaat ggcgaggtac aagctgagat   1620

caagaaatct tggagccgct ggacactggc actggacttc aagcgaaagg cacgcagcgg   1680

gagcagcagc tatagctacg gccccatggt gtcccacaca agtgtgacca atgtcggccc   1740

ccgtgtggga ctcggcctgc ccctcagccc ccgcctactg cccactgcca ccaccaacgg   1800

ccaccctcag ctgcctggcc atgccaagcc agggacccca gccctggaga ccctcgagac   1860

cacaccacct gccatggctg ctcccaagga cgatgggttc ctcaacggct cctgctcagg   1920

cctggacgag gaggcctctg ggcctgagcg gccacctgcc ctgctacagg aagagtggga   1980

gacagtcatg tgaccaggcg ctgggggctg gacctgctga catagtggat ggacagatgg   2040

accaaaagat gggtggttga atgatttccc actcagggct ggggccaaga ggaaaaacag   2100

ggaaaaaaag aaaaaaaaaa gaaaaaggaa aagga                              2135


<210>  9276
<211>  593
<212>  PRT
<213>  Homosapiens

<400>  9276

Met Gly Thr Ala Arg Ile Ala Pro Gly Leu Ala Leu Leu Leu Cys Cys 
1               5                   10                  15      


Pro Val Leu Ser Ser Ala Tyr Ala Leu Val Asp Ala Asp Asp Val Met 
            20                  25                  30          


Thr Lys Glu Glu Gln Ile Phe Leu Leu His Arg Ala Gln Ala Gln Cys 
        35                  40                  45              


Glu Lys Arg Leu Lys Glu Val Leu Gln Arg Pro Ala Ser Ile Met Glu 
    50                  55                  60                  


Ser Asp Lys Gly Trp Thr Ser Ala Ser Thr Ser Gly Lys Pro Arg Lys 
65                  70                  75                  80  


Asp Lys Ala Ser Gly Lys Leu Tyr Pro Glu Ser Glu Glu Asp Lys Glu 
                85                  90                  95      


Ala Pro Thr Gly Ser Arg Tyr Arg Gly Arg Pro Cys Leu Pro Glu Trp 
            100                 105                 110         


Asp His Ile Leu Cys Trp Pro Leu Gly Ala Pro Gly Glu Val Val Ala 
        115                 120                 125             


Val Pro Cys Pro Asp Tyr Ile Tyr Asp Phe Asn His Lys Gly His Ala 
    130                 135                 140                 


Tyr Arg Arg Cys Asp Arg Asn Gly Ser Trp Glu Leu Val Pro Gly His 
145                 150                 155                 160 


Asn Arg Thr Trp Ala Asn Tyr Ser Glu Cys Val Lys Phe Leu Thr Asn 
                165                 170                 175     


Glu Thr Arg Glu Arg Glu Val Phe Asp Arg Leu Gly Met Ile Tyr Thr 
            180                 185                 190         


Val Gly Tyr Ser Val Ser Leu Ala Ser Leu Thr Val Ala Val Leu Ile 
        195                 200                 205             


Leu Ala Tyr Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Met 
    210                 215                 220                 


His Leu Phe Leu Ser Phe Met Leu Arg Ala Val Ser Ile Phe Val Lys 
225                 230                 235                 240 


Asp Ala Val Leu Tyr Ser Gly Ala Thr Leu Asp Glu Ala Glu Arg Leu 
                245                 250                 255     


Thr Glu Glu Glu Leu Arg Ala Ile Ala Gln Ala Pro Pro Pro Pro Ala 
            260                 265                 270         


Thr Ala Ala Ala Gly Tyr Ala Gly Cys Arg Val Ala Val Thr Phe Phe 
        275                 280                 285             


Leu Tyr Phe Leu Ala Thr Asn Tyr Tyr Trp Ile Leu Val Glu Gly Leu 
    290                 295                 300                 


Tyr Leu His Ser Leu Ile Phe Met Ala Phe Phe Ser Glu Lys Lys Tyr 
305                 310                 315                 320 


Leu Trp Gly Phe Thr Val Phe Gly Trp Gly Leu Pro Ala Val Phe Val 
                325                 330                 335     


Ala Val Trp Val Ser Val Arg Ala Thr Leu Ala Asn Thr Gly Cys Trp 
            340                 345                 350         


Asp Leu Ser Ser Gly Asn Lys Lys Trp Ile Ile Gln Val Pro Ile Leu 
        355                 360                 365             


Ala Ser Ile Val Leu Asn Phe Ile Leu Phe Ile Asn Ile Val Arg Val 
    370                 375                 380                 


Leu Ala Thr Lys Leu Arg Glu Thr Asn Ala Gly Arg Cys Asp Thr Arg 
385                 390                 395                 400 


Gln Gln Tyr Arg Lys Leu Leu Lys Ser Thr Leu Val Leu Met Pro Leu 
                405                 410                 415     


Phe Gly Val His Tyr Ile Val Phe Met Ala Thr Pro Tyr Thr Glu Val 
            420                 425                 430         


Ser Gly Thr Leu Trp Gln Val Gln Met His Tyr Glu Met Leu Phe Asn 
        435                 440                 445             


Ser Phe Gln Gly Phe Phe Val Ala Ile Ile Tyr Cys Phe Cys Asn Gly 
    450                 455                 460                 


Glu Val Gln Ala Glu Ile Lys Lys Ser Trp Ser Arg Trp Thr Leu Ala 
465                 470                 475                 480 


Leu Asp Phe Lys Arg Lys Ala Arg Ser Gly Ser Ser Ser Tyr Ser Tyr 
                485                 490                 495     


Gly Pro Met Val Ser His Thr Ser Val Thr Asn Val Gly Pro Arg Val 
            500                 505                 510         


Gly Leu Gly Leu Pro Leu Ser Pro Arg Leu Leu Pro Thr Ala Thr Thr 
        515                 520                 525             


Asn Gly His Pro Gln Leu Pro Gly His Ala Lys Pro Gly Thr Pro Ala 
    530                 535                 540                 


Leu Glu Thr Leu Glu Thr Thr Pro Pro Ala Met Ala Ala Pro Lys Asp 
545                 550                 555                 560 


Asp Gly Phe Leu Asn Gly Ser Cys Ser Gly Leu Asp Glu Glu Ala Ser 
                565                 570                 575     


Gly Pro Glu Arg Pro Pro Ala Leu Leu Gln Glu Glu Trp Glu Thr Val 
            580                 585                 590         


Met 
    


<210>  9277
<211>  2033
<212>  DNA
<213>  Homosapiens

<400>  9277
cgctgctcgc tcgctcgctc gctcgctcgc cctcagcgca tgggccccgc gccgggcccc     60

ggggcctcgg gccgccggga cgccggggtc ccataggccg gggcgtgggc ggggcggcca    120

gcctgacgca gctctgcacc ccctaccacc accagggccg gcggcggcgg ctgccccgag    180

ggacgcggcc ctaggcggtg gcgatgggga ccgcccggat cgcacccggc ctggcgctcc    240

tgctctgctg ccccgtgctc agctccgcgt acgcgctggt ggatgcagat gacgtcatga    300

ctaaagagga acagatcttc ctgctgcacc gtgctcaggc ccagtgcgaa aaacggctca    360

aggaggtcct gcagaggcca gccagcataa tggaatcaga caagggatgg acatctgcgt    420

ccacatcagg gaagcccagg aaagataagg catctgggaa gctctaccct gagtctgagg    480

aggacaagga ggcacccact ggcagcaggt accgagggcg cccctgtctg ccggaatggg    540

accacatcct gtgctggccg ctgggggcac caggtgaggt ggtggctgtg ccctgtccgg    600

actacattta tgacttcaat cacaaaggcc atgcctaccg acgctgtgac cgcaatggca    660

gctgggagct ggtgcctggg cacaacagga cgtgggccaa ctacagcgag tgtgtcaaat    720

ttctcaccaa tgagactcgt gaacgggagg tgtttgaccg cctgggcatg atttacaccg    780

tgggctactc cgtgtccctg gcgtccctca ccgtagctgt gctcatcctg gcctacttta    840

ggcggctgca ctgcacgcgc aactacatcc acatgcacct gttcctgtcc ttcatgctgc    900

gcgccgtgag catcttcgtc aaggacgctg tgctctactc tggcgccacg cttgatgagg    960

ctgagcgcct caccgaggag gagctgcgcg ccatcgccca ggcgcccccg ccgcctgcca   1020

ccgccgctgc cggctacgcg ggctgcaggg tggctgtgac cttcttcctt tacttcctgg   1080

ccaccaacta ctactggatt ctggtggagg ggctgtacct gcacagcctc atcttcatgg   1140

ccttcttctc agagaagaag tacctgtggg gcttcacagt cttcggctgg ggtgctggga   1200

cttgagctcc gggaacaaaa agtggatcat ccaggtgccc atcctggcct ccattgtgct   1260

caacttcatc ctcttcatca atatcgtccg ggtgctcgcc accaagctgc gggagaccaa   1320

cgccggccgg tgtgacacac ggcagcagta ccggaagctg ctcaaatcca cgctggtgct   1380

catgcccctc tttggcgtcc actacattgt cttcatggcc acaccataca ccgaggtctc   1440

agggacgctc tggcaagtcc agatgcacta tgagatgctc ttcaactcct tccagggatt   1500

ttttgtcgca atcatatact gtttctgcaa tggcgaggta caagctgaga tcaagaaatc   1560

ttggagccgc tggacactgg cactggactt caagcgaaag gcacgcagcg ggagcagcag   1620

ctatagctac ggccccatgg tgtcccacac aagtgtgacc aatgtcggcc cccgtgtggg   1680

actcggcctg cccctcagcc cccgcctact gcccactgcc accaccaacg gccaccctca   1740

gctgcctggc catgccaagc cagggacccc agccctggag accctcgaga ccacaccacc   1800

tgccatggct gctcccaagg acgatgggtt cctcaacggc tcctgctcag gcctggacga   1860

ggaggcctct gggcctgagc ggccacctgc cctgctacag gaagagtggg agacagtcat   1920

gtgaccaggc gctgggggct ggacctgctg acatagtgga tggacagatg gaccaaaaga   1980

tgggtggttg aatgatttcc cactcagggc tggggccaag aggaaaaaca ggg          2033


<210>  9278
<211>  333
<212>  PRT
<213>  Homosapiens

<400>  9278

Met Gly Thr Ala Arg Ile Ala Pro Gly Leu Ala Leu Leu Leu Cys Cys 
1               5                   10                  15      


Pro Val Leu Ser Ser Ala Tyr Ala Leu Val Asp Ala Asp Asp Val Met 
            20                  25                  30          


Thr Lys Glu Glu Gln Ile Phe Leu Leu His Arg Ala Gln Ala Gln Cys 
        35                  40                  45              


Glu Lys Arg Leu Lys Glu Val Leu Gln Arg Pro Ala Ser Ile Met Glu 
    50                  55                  60                  


Ser Asp Lys Gly Trp Thr Ser Ala Ser Thr Ser Gly Lys Pro Arg Lys 
65                  70                  75                  80  


Asp Lys Ala Ser Gly Lys Leu Tyr Pro Glu Ser Glu Glu Asp Lys Glu 
                85                  90                  95      


Ala Pro Thr Gly Ser Arg Tyr Arg Gly Arg Pro Cys Leu Pro Glu Trp 
            100                 105                 110         


Asp His Ile Leu Cys Trp Pro Leu Gly Ala Pro Gly Glu Val Val Ala 
        115                 120                 125             


Val Pro Cys Pro Asp Tyr Ile Tyr Asp Phe Asn His Lys Gly His Ala 
    130                 135                 140                 


Tyr Arg Arg Cys Asp Arg Asn Gly Ser Trp Glu Leu Val Pro Gly His 
145                 150                 155                 160 


Asn Arg Thr Trp Ala Asn Tyr Ser Glu Cys Val Lys Phe Leu Thr Asn 
                165                 170                 175     


Glu Thr Arg Glu Arg Glu Val Phe Asp Arg Leu Gly Met Ile Tyr Thr 
            180                 185                 190         


Val Gly Tyr Ser Val Ser Leu Ala Ser Leu Thr Val Ala Val Leu Ile 
        195                 200                 205             


Leu Ala Tyr Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Met 
    210                 215                 220                 


His Leu Phe Leu Ser Phe Met Leu Arg Ala Val Ser Ile Phe Val Lys 
225                 230                 235                 240 


Asp Ala Val Leu Tyr Ser Gly Ala Thr Leu Asp Glu Ala Glu Arg Leu 
                245                 250                 255     


Thr Glu Glu Glu Leu Arg Ala Ile Ala Gln Ala Pro Pro Pro Pro Ala 
            260                 265                 270         


Thr Ala Ala Ala Gly Tyr Ala Gly Cys Arg Val Ala Val Thr Phe Phe 
        275                 280                 285             


Leu Tyr Phe Leu Ala Thr Asn Tyr Tyr Trp Ile Leu Val Glu Gly Leu 
    290                 295                 300                 


Tyr Leu His Ser Leu Ile Phe Met Ala Phe Phe Ser Glu Lys Lys Tyr 
305                 310                 315                 320 


Leu Trp Gly Phe Thr Val Phe Gly Trp Gly Ala Gly Thr 
                325                 330             


<210>  9279
<211>  744
<212>  DNA
<213>  Homosapiens

<400>  9279
tggccctgac ctacctgccc cgctggccca ggaagctgct caaatccacg ctggtgctca     60

tgcccctctt tggcgtccac tacattgtct tcatggccac accatacacc gaggtctcag    120

ggacgctctg gcaagtccag atgcactatg agatgctctt caactccttc cagggatttt    180

ttgtcgcaat catatactgt ttctgcaatg gcgaggtaca agctgagatc aagaaatctt    240

ggagccgctg gacactggca ctggacttca agcgaaaggc acgcagcggg agcagcagct    300

atagctacgg ccccatggtg tcccacacaa gtgtgaccaa tgtcggcccc cgtgtgggac    360

tcggcctgcc cctcagcccc cgcctactgc ccactgccac caccaacggc caccctcagc    420

tgcctggcca tgccaagcca gggaccccag ccctggagac cctcgagacc acaccacctg    480

ccatggctgc tcccaaggac gatgggttcc tcaacggctc ctgctcaggc ctggacgagg    540

aggcctctgg gcctgagcgg ccacctgccc tgctacagga agagtgggag acagtcatgt    600

gaccaggcgc tgggggctgg acctgctgac atagtggatg gacagatgga ccaaaagatg    660

ggtggttgaa tgatttccca ctcagggctg gggccaagag gaaaaacagg gaaaaaaaga    720

aaaaaaaaag aaaaaggaaa agga                                           744


<210>  9280
<211>  180
<212>  PRT
<213>  Homosapiens

<400>  9280

Met Pro Leu Phe Gly Val His Tyr Ile Val Phe Met Ala Thr Pro Tyr 
1               5                   10                  15      


Thr Glu Val Ser Gly Thr Leu Trp Gln Val Gln Met His Tyr Glu Met 
            20                  25                  30          


Leu Phe Asn Ser Phe Gln Gly Phe Phe Val Ala Ile Ile Tyr Cys Phe 
        35                  40                  45              


Cys Asn Gly Glu Val Gln Ala Glu Ile Lys Lys Ser Trp Ser Arg Trp 
    50                  55                  60                  


Thr Leu Ala Leu Asp Phe Lys Arg Lys Ala Arg Ser Gly Ser Ser Ser 
65                  70                  75                  80  


Tyr Ser Tyr Gly Pro Met Val Ser His Thr Ser Val Thr Asn Val Gly 
                85                  90                  95      


Pro Arg Val Gly Leu Gly Leu Pro Leu Ser Pro Arg Leu Leu Pro Thr 
            100                 105                 110         


Ala Thr Thr Asn Gly His Pro Gln Leu Pro Gly His Ala Lys Pro Gly 
        115                 120                 125             


Thr Pro Ala Leu Glu Thr Leu Glu Thr Thr Pro Pro Ala Met Ala Ala 
    130                 135                 140                 


Pro Lys Asp Asp Gly Phe Leu Asn Gly Ser Cys Ser Gly Leu Asp Glu 
145                 150                 155                 160 


Glu Ala Ser Gly Pro Glu Arg Pro Pro Ala Leu Leu Gln Glu Glu Trp 
                165                 170                 175     


Glu Thr Val Met 
            180 


<210>  9281
<211>  852
<212>  DNA
<213>  Homosapiens

<400>  9281
gtcgtctttg tggctggggg tcttgcccca ctagcccagt gtggggaaag aagagccctt     60

tctgcttttc cttctctgcc cttacccagg gcaggtgtct gccgctcctt cccctgagga    120

caaggaagat ggggagccaa agaccaagca tctcagagaa gaggaggaag aaggcgagaa    180

gcacagggaa cttaggctgc ggaactatgt cccggaggat gaggacctga agaagaggag    240

ggtgccccag gccaaaccgg ttgcagtgga ggagaaggtg aaggagcagc tggaggccgc    300

caagcccgag cccgtcatcg aggaggtgga cctggccaac ctcgctcctc ggaagcctga    360

ctgggacctc aagagagatg tggccaagaa gctggagaaa ctaaaaaagc ggactcagag    420

ggccattgcc gagctgatcc gtgaaaggct gaaaggccag gaagacagcc tagcctctgc    480

agtggatgct gccaccgaac aaaagacctg tgactccgac tgaggcatgc cctgccccac    540

cactcgccca tcaggcctgt cctgcagagg atggtcttgg gcagggatgg gggctaggct    600

tgccatcacc tccagtttgg cttctgagca gagactccct gcccatcaag tctgaaaccc    660

ccatggatga ggtcagctcc ttgtctgctg ggtggcccct gccattctga atggaggcag    720

aaccagcaac aactctgggc gtgcctgtgt ctgcacatgt ggatgtacat atgtctgtat    780

atatgtatat attttgaact ttctaaaaaa aaatctggaa atagaaacaa gtaaacccct    840

gtgtgtggca ga                                                        852


<210>  9282
<211>  33
<212>  PRT
<213>  Homosapiens

<400>  9282

Met Gly Ser Gln Arg Pro Ser Ile Ser Glu Lys Arg Arg Lys Lys Ala 
1               5                   10                  15      


Arg Ser Thr Gly Asn Leu Gly Cys Gly Thr Met Ser Arg Arg Met Arg 
            20                  25                  30          


Thr 
    


<210>  9283
<211>  779
<212>  DNA
<213>  Homosapiens

<400>  9283
gcgacccgca gtccatctga ctcctgcttc ccgggtgttg ctcgtgacaa ggaagatggg     60

gagccaaaga ccaagcatct cagagaagag gaggaagaag gcgagaagca cagggaactt    120

aggctgcgga actatgtccc ggaggatgag gacctgaaga agaggagggt gccccaggcc    180

aaaccggttg cagtggagga gaaggtgaag gagcagctgg aggccgccaa gcccgagccc    240

gtcatcgagg aggtggacct ggccaacctc gctcctcgga agcctgactg ggacctcaag    300

agagatgtgg ccaagaagct ggagaaacta aaaaagcgga ctcagagggc cattgccgag    360

ctgatccgtg aaaggctgaa aggccaggaa gacagcctag cctctgcagt ggatgctgcc    420

accgaacaaa agacctgtga ctccgactga ggcatgccct gccccaccac tcgcccatca    480

ggcctgtcct gcagaggatg gtcttgggca gggatggggg ctaggcttgc catcacctcc    540

agtttggctt ctgagcagag actccctgcc catcaagtct gaaaccccca tggatgaggt    600

cagctccttg tctgctgggt ggcccctgcc attctgaatg gaggcagaac cagcaacaac    660

tctgggcgtg cctgtgtctg cacatgtgga tgtacatatg tctgtatata tgtatatatt    720

ttgaactttc taaaaaaaaa tctggaaata gaaacaagta aacccctgtg tgtggcaga     779


<210>  9284
<211>  33
<212>  PRT
<213>  Homosapiens

<400>  9284

Met Gly Ser Gln Arg Pro Ser Ile Ser Glu Lys Arg Arg Lys Lys Ala 
1               5                   10                  15      


Arg Ser Thr Gly Asn Leu Gly Cys Gly Thr Met Ser Arg Arg Met Arg 
            20                  25                  30          


Thr 
    


<210>  9285
<211>  393
<212>  DNA
<213>  Homosapiens

<400>  9285
gggcaagatg gaggcaacta cggctggtgt gggccggcta gaggaagagg cgttgcggcg     60

aaaggaacgg ctgaaggccc tacgggagaa aaccgggcgc aaggtgagaa gatggtcttg    120

ggcagggatg ggggctaggc ttgccatcac ctccagtttg gcttctgagc agagactccc    180

tgcccatcaa gtctgaaacc cccatggatg aggtcagctc cttgtctgct gggtggcccc    240

tgccattctg aatggaggca gaaccagcaa caactctggg cgtgcctgtg tctgcacatg    300

tggatgtaca tatgtctgta tatatgtata tattttgaac tttctaaaaa aaaatctgga    360

aatagaaaca agtaaacccc tgtgtgtggc aga                                 393


<210>  9286
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  9286

Met Glu Ala Thr Thr Ala Gly Val Gly Arg Leu Glu Glu Glu Ala Leu 
1               5                   10                  15      


Arg Arg Lys Glu Arg Leu Lys Ala Leu Arg Glu Lys Thr Gly Arg Lys 
            20                  25                  30          


Val Arg Arg Trp Ser Trp Ala Gly Met Gly Ala Arg Leu Ala Ile Thr 
        35                  40                  45              


Ser Ser Leu Ala Ser Glu Gln Arg Leu Pro Ala His Gln Val 
    50                  55                  60          


<210>  9287
<211>  1097
<212>  DNA
<213>  Homosapiens

<400>  9287
aaaggagggg cgtacgcggg caagatggag gcaactacgg ctggtgtggg ccggctagag     60

gaagaggcgt tgcggcgaaa ggaacggctg aaggccctac gggagaaaac cgggcgcaag    120

gacaaggaag atggggagcc aaagaccaag catctcagag aagaggagga agaaggcgag    180

aagcacaggg aacttaggct gcggaactat gtcccggagg atgaggacct gaagaagagg    240

agggtgcccc aggccaaacc ggttgcagtg gaggagaagg tgaaggagca gctggaggcc    300

gccaagcccg agcccgtcat cgaggaggtg gtgagtgcct ggaccaccct ggcatcctcg    360

ctgcttctgt gtgtcctgtt tctcttcgcc acttgctctc cctctgcccc ccattccttc    420

tcgtcacttc tttattccct tcccaccagc ccctttgctc tcgtccctct ccttcctcct    480

cctctttctc ccatttccct ccttctcgag cctgccctcc cccttgtcct ggggtggccc    540

ctccaccctg atgtgtgtct cctcccttcc caggacctgg ccaacctcgc tcctcggaag    600

cctgactggg acctcaagag agatgtggcc aagaagctgg agaaactaaa aaagcggact    660

cagagggcca ttgccgagct gatccgtgaa aggctgaaag gccaggaaga cagcctagcc    720

tctgcagtgg atgctgccac cgaacaaaag acctgtgact ccgactgagg catgccctgc    780

cccaccactc gcccatcagg cctgtcctgc agaggatggt cttgggcagg gatgggggct    840

aggcttgcca tcacctccag tttggcttct gagcagagac tccctgccca tcaagtctga    900

aacccccatg gatgaggtca gctccttgtc tgctgggtgg cccctgccat tctgaatgga    960

ggcagaacca gcaacaactc tgggcgtgcc tgtgtctgca catgtggatg tacatatgtc   1020

tgtatatatg tatatatttt gaactttcta aaaaaaaatc tggaaataga aacaagtaaa   1080

cccctgtgtg tggcaga                                                  1097


<210>  9288
<211>  247
<212>  PRT
<213>  Homosapiens

<400>  9288

Met Glu Ala Thr Thr Ala Gly Val Gly Arg Leu Glu Glu Glu Ala Leu 
1               5                   10                  15      


Arg Arg Lys Glu Arg Leu Lys Ala Leu Arg Glu Lys Thr Gly Arg Lys 
            20                  25                  30          


Asp Lys Glu Asp Gly Glu Pro Lys Thr Lys His Leu Arg Glu Glu Glu 
        35                  40                  45              


Glu Glu Gly Glu Lys His Arg Glu Leu Arg Leu Arg Asn Tyr Val Pro 
    50                  55                  60                  


Glu Asp Glu Asp Leu Lys Lys Arg Arg Val Pro Gln Ala Lys Pro Val 
65                  70                  75                  80  


Ala Val Glu Glu Lys Val Lys Glu Gln Leu Glu Ala Ala Lys Pro Glu 
                85                  90                  95      


Pro Val Ile Glu Glu Val Val Ser Ala Trp Thr Thr Leu Ala Ser Ser 
            100                 105                 110         


Leu Leu Leu Cys Val Leu Phe Leu Phe Ala Thr Cys Ser Pro Ser Ala 
        115                 120                 125             


Pro His Ser Phe Ser Ser Leu Leu Tyr Ser Leu Pro Thr Ser Pro Phe 
    130                 135                 140                 


Ala Leu Val Pro Leu Leu Pro Pro Pro Leu Ser Pro Ile Ser Leu Leu 
145                 150                 155                 160 


Leu Glu Pro Ala Leu Pro Leu Val Leu Gly Trp Pro Leu His Pro Asp 
                165                 170                 175     


Val Cys Leu Leu Pro Ser Gln Asp Leu Ala Asn Leu Ala Pro Arg Lys 
            180                 185                 190         


Pro Asp Trp Asp Leu Lys Arg Asp Val Ala Lys Lys Leu Glu Lys Leu 
        195                 200                 205             


Lys Lys Arg Thr Gln Arg Ala Ile Ala Glu Leu Ile Arg Glu Arg Leu 
    210                 215                 220                 


Lys Gly Gln Glu Asp Ser Leu Ala Ser Ala Val Asp Ala Ala Thr Glu 
225                 230                 235                 240 


Gln Lys Thr Cys Asp Ser Asp 
                245         


<210>  9289
<211>  855
<212>  DNA
<213>  Homosapiens

<400>  9289
aaaaggaggg gcgtacgcgg gcaagatgga ggcaactacg gctggtgtgg gccggctaga     60

ggaagaggcg ttgcggcgaa aggaacggct gaaggcccta cgggagaaaa ccgggcgcaa    120

ggacaaggaa gatggggagc caaagaccaa gcatctcaga gaagaggagg aagaaggcga    180

gaagcacagg gaacttaggc tgcggaacta tgtcccggag gatgaggacc tgaagaagag    240

gagggtgccc caggccaaac cggttgcagt ggaggagaag gtgaaggagc agctggaggc    300

cgccaagccc gagcccgtca tcgaggaggt ggacctggcc aacctcgctc ctcggaagcc    360

tgactgggac ctcaagagag atgtggccaa gaagctggag aaactaaaaa agcggactca    420

gagggccatt gccgagctga tccgtgaaag gctgaaaggc caggaagaca gcctagcctc    480

tgcagtggat gctgccaccg aacaaaagac ctgtgactcc gactgaggca tgccctgccc    540

caccactcgc ccatcaggcc tgtcctgcag aggatggtct tgggcaggga tgggggctag    600

gcttgccatc acctccagtt tggcttctga gcagagactc cctgcccatc aagtctgaaa    660

cccccatgga tgaggtcagc tccttgtctg ctgggtggcc cctgccattc tgaatggagg    720

cagaaccagc aacaactctg ggcgtgcctg tgtctgcaca tgtggatgta catatgtctg    780

tatatatgta tatattttga actttctaaa aaaaaatctg gaaatagaaa caagtaaacc    840

cctgtgtgtg gcaga                                                     855


<210>  9290
<211>  166
<212>  PRT
<213>  Homosapiens

<400>  9290

Met Glu Ala Thr Thr Ala Gly Val Gly Arg Leu Glu Glu Glu Ala Leu 
1               5                   10                  15      


Arg Arg Lys Glu Arg Leu Lys Ala Leu Arg Glu Lys Thr Gly Arg Lys 
            20                  25                  30          


Asp Lys Glu Asp Gly Glu Pro Lys Thr Lys His Leu Arg Glu Glu Glu 
        35                  40                  45              


Glu Glu Gly Glu Lys His Arg Glu Leu Arg Leu Arg Asn Tyr Val Pro 
    50                  55                  60                  


Glu Asp Glu Asp Leu Lys Lys Arg Arg Val Pro Gln Ala Lys Pro Val 
65                  70                  75                  80  


Ala Val Glu Glu Lys Val Lys Glu Gln Leu Glu Ala Ala Lys Pro Glu 
                85                  90                  95      


Pro Val Ile Glu Glu Val Asp Leu Ala Asn Leu Ala Pro Arg Lys Pro 
            100                 105                 110         


Asp Trp Asp Leu Lys Arg Asp Val Ala Lys Lys Leu Glu Lys Leu Lys 
        115                 120                 125             


Lys Arg Thr Gln Arg Ala Ile Ala Glu Leu Ile Arg Glu Arg Leu Lys 
    130                 135                 140                 


Gly Gln Glu Asp Ser Leu Ala Ser Ala Val Asp Ala Ala Thr Glu Gln 
145                 150                 155                 160 


Lys Thr Cys Asp Ser Asp 
                165     


<210>  9291
<211>  399
<212>  DNA
<213>  Homosapiens

<400>  9291
ggtcgtcgcg catgcgcggg ggtgggcaag gcagtggtca gcgacccgca gtccatctga     60

ctcctgcttc ccgggtgttg ctcgtgacaa ggaagatggg gagccaaaga ccaagcatct    120

cagagaagag gaggaagaag gcgagaagca cagggaactt aggctgcgga actatgtccc    180

ggaggatgag gacctgaaga agaggagggt gccccaggcc aaaccggttg caggtaagca    240

agctgtccct ctccacctct gcttcctggc actgtcagcc accctccacc tcagcaggct    300

ttgctctctg agaataacca gcagtaccag gacaggagtt gggcctgcag gcaggaccct    360

ttgttaccat ctcatggcag atgcacacag tcggccttc                           399


<210>  9292
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  9292

Met Arg Gly Gly Gly Gln Gly Ser Gly Gln Arg Pro Ala Val His Leu 
1               5                   10                  15      


Thr Pro Ala Ser Arg Val Leu Leu Val Thr Arg Lys Met Gly Ser Gln 
            20                  25                  30          


Arg Pro Ser Ile Ser Glu Lys Arg Arg Lys Lys Ala Arg Ser Thr Gly 
        35                  40                  45              


Asn Leu Gly Cys Gly Thr Met Ser Arg Arg Met Arg Thr 
    50                  55                  60      


<210>  9293
<211>  997
<212>  DNA
<213>  Homosapiens

<400>  9293
tggccccagg ctgcccactg tctgctcagg cttccaaagc tacaacctgc cagcctatgc     60

tccatacctg ccctgcgagg cctgcgcgat gcaagacggg agaaaaggag gggcgtacgc    120

gggcaagatg gaggcaacta cggctggtgt gggccggcta gaggaagagg cgttgcggcg    180

aaaggaacgg ctgaaggccc tacgggagaa aaccgggcgc aaggtgagaa gtgtggagtg    240

agggtcgcag ttgaggcgtc cagcgttcgg ggtccgggtc gcgcttgagg agagcaaagg    300

gctaataagg aaagacagct gccgagggcg cgcatgcgcg ggcgctaacg catgcgcgag    360

aagacggcgc cctcccacga tgtctggggc tgcttggcgt gggactcctc tggcgctggt    420

gcggtcgtcg cgcatgcgcg ggggtgggca aggcagtggt cagcgacccg cagtccatct    480

gactcctgct tcccgggtgt tgctcgtgta ggtatctagg gctgcctgta ggttcagatg    540

cttgttgggt taggcgtgat ttgttccgtt cctctatggc ctagctggtc tttaaccccc    600

gccttcgatt ctgagtcaga cagactcccc agtccggcag cactccttgg acagggcagc    660

aagtgacagc agtgggtata cagccggagt cgtttcgtgc aaaaatcaaa aagaggccgg    720

gcacggtggc tcacgcctgt aatcccagtg ctttgggagg ccgaggcagg cggatcactt    780

gaggttagta gttcgagacc aggctgggta acatggtgaa accccgcctc tactaaaaat    840

acaaaaatta gccgggcgtg gtggtgcgcg cctgtaatcc cagcttctcg ggaggctatg    900

gcaggagaac cgcttgagcc tgggaggcag aggttgtagt gagccgagat ctcgccactg    960

tactccagcc tgggcaacag agcgagactc cgtctca                             997


<210>  9294
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  9294

Met Leu His Thr Cys Pro Ala Arg Pro Ala Arg Cys Lys Thr Gly Glu 
1               5                   10                  15      


Lys Glu Gly Arg Thr Arg Ala Arg Trp Arg Gln Leu Arg Leu Val Trp 
            20                  25                  30          


Ala Gly 
        


<210>  9295
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9295
gccggagccg ggccgggcca tggccgcctc ggagcggctg tacgagttgt ggctgctcta     60

ctacgcgcag aaggacctgg gttacctgca gcagtggctg aaggcctttg taggtgcctt    120

caagaagagc atctcactgt cctctctgga gccacgaagg ccagaggagg caggtgcaga    180

ggtcccgctg ctaccactgg atgagctgca tgtgctggcc gaacagctgc accaggctga    240

cctggagcaa gccctcctgc tgctcaagct cttcatcatt ctctgcagga acctggagaa    300

catagaggca ggccggggcc aagtgctagt gccccgagtg ctggcactgt tgaccaagtt    360

ggtggcggag ctgaaaggat gcccaccacc ccagggccga ggcacgcagt tggagaatgt    420

ggccctacat gctctgcttc tctgcgaggg cctctttgac ccttaccaaa cctggcggcg    480

ccagcgcagt ggggaagtca tcagctccaa ggagaagagc aaatacaagt tccctcctgc    540

tgctttgccc caggaattca gcgccttctt ccaagagagc ctacagaatg cagaccactt    600

gcctcccata ctgctgttac gtctcatcca cctcttctgc gccgtcctcg ctggaggaaa    660

ggagaacggg cagatggctg taagtgatgg ctctgtgaag ggcctgctga gtgtggtgcg    720

gggctggagc cgtgggccag ccccggaccc gtgcctagtg ccactggctc tagaggcact    780

ggtaggtgca gtccatgtct tgcatgccag ccgcgcacct cctcgtggcc cagagcttcg    840

tgccctgctt gagagctact tccatgtcct taatgctgac tggccagctg gtctgagctc    900

aggccccgaa gaggcccttg tcaccctccg ggtcagcatg ctcgacgcca tccccatgat    960

gctggcatgt gaagaccggc cagtgctgca agccaccttc ctcagcaaca attgctttga   1020

acacctcact cggctcattc agaacagcaa gctgtacctg cagtcccggg cgccccccga   1080

gggggacagt gacctggcta cccggttact gactgagccc gatgtccaaa aggtcctgga   1140

ccaagacaca gacgccattg cagtccatgt agtcagagtg ctgacctgca tcatgagtga   1200

ctccccctcg gccaaggagg tgtttaagga gcgcatcggc taccctcacc tgcaggaggt   1260

tctgcagagc catggtcccc ccacccatcg gctgttgcaa gagctgctca acatggctgt   1320

ggagggtgac cacagcatgt gcccacctcc accaatccgc aacgagcagc cggtactggt   1380

gctggcgcag tggctgccgt cattgcccac cgctgagctg cggctcttcc tagcgcaacg   1440

cctcaggtgg ctctgtgaca gctgccctgc cagccgtgcc acctgtgtgc aggcaggcct   1500

ggtgggctgc ctgttggaga cactcagcac agggctagcc ctggaggccc gctgccaaga   1560

gcagctgctg gcactgctac aagcactggg ccgtgtatca ataaggccca tggagctgcg   1620

tcacctgctg cgcccccggc caggattgga ctcggaacca ggcggagctg aggctggaaa   1680

ggcccgacac gcaggtgctg tcatccgcac attatcaggc atggccaggc accagggtcc   1740

tgcacgtgct ctgcgctact ttgacctcac gcccagcatg gcgggcatca tggtaccccc   1800

tgtacagcga tggccagggc ctggcttcac ctttcatgcc tggctctgtc tgcaccctat   1860

ggatacagca cctacccctg cccccacccg accactccag cgaaagcagc tgtacagctt   1920

ctttaccagc agcggctcag ggtttgaggc cttcttcacg gcggccggga ccctggtggt   1980

ggctgtgtgc acacggaagg agtatttgac catgagtttg cccgaagtgt cctttgccga   2040

ctctgcctgg cactgcgtgg ctatcgtcca tgtgcctggg cgccggccct tcagccagaa   2100

cctggtccat gtctacaaag acggccatct ggtcaagaca gcaccccttc gctgcccctc   2160

cctcagtgag cctttctcct cctgctgtat cggctccgct ggataccgca caacgaccac   2220

caccacaggg ctgcccacac caccagtccc cgccaccctg gcctacactc accccgccct   2280

cacccgctcc cagtcagtcc cagcctccac agggcttggc tgggggtccg ggctggtggc   2340

ccccctgcag gagggcagca tcgactctac cctcgcaggc acccaggaca ctcggtgggg   2400

cagccccaca tccctggagg gtgagctggg ggctgtggcc atctttcacg aagccctgca   2460

ggcgacggct ctgaggaccc tgtgcaccct ggggcccaat gagacggcac ccttcaagcc   2520

tgagggggag ctgcatgagc tcagcaccag gctgctcctc cattactcac ctcaggcttg   2580

taagaacaac atctgcctgg acctgtcccc cagtcatggg cttgatgggc gcctgacggg   2640

ccacagagtg gagacctggg atgtgaagga tgtggtgaac tgcgttgggg gtatgggtgc   2700

cctgctgccc ctgctggagc gagtagctgc acagcccaaa gaggctgaag caggtccagc   2760

tgaaacgcat gacctcgtgg gtcctgaact gacctctggt cacaacaccc agggcctggt   2820

tctcccattg ggtaaatctt cagaggaacg gatggagagg aacgcagtgg ctgcttttct   2880

gctgatgctg cggaacttcc ttcagggtca catggtgaac caagagagcc tggtgcagtg   2940

ccaggggcct gccatcatcg gggccctcct gcgaaaggtc ccaagctggg ccatggacat   3000

gaacgtgctc atgtccgccc agctgctgat ggagcaggtg gcagctgagg gcagcgggcc   3060

cctcctgtac ctactctacc agcatttgct cttcaacttt cacctctgga ccctcagtga   3120

cttcgccgtg cgcctcggtc acatccagta catgtccagc atagttcggg agcacagaca   3180

gaagctgcgg aagaagtacg gcgtccagtt tatcttggat gctctgcgca cccactacag   3240

cccgcagcgg gagcgccccc tggctgctga cgacctacgc accgtgcaga cctccctcct   3300

gggcctggcg agggagttcc tggtgcggag tctctcagca gatgacgtgc aggtcacgca   3360

gaccatgctg agctttttgg cggccacagg cgatgacggt caggcggtgg gtgcgctgga   3420

cctgctgctg gccctgctgc acggttccct ggtgcaggag tccttggctg tctttctgtt   3480

ggagccaggg aacctcgaag tgctactggc cctgctagtg cggccagggt cactgcccct   3540

gctgcccgat cgagtctgca agatcctgcg cagactgcag cagaatgagc ggctacctga   3600

gcggagccgc cagcgcctcc ggctgcggga gtgtggtctc cagggtctgg ttgcctgctt   3660

gcctgagggg actgtttccc cccagctctg ccagggcctc tacaagctgt tcctgggggc   3720

agattgcctg aacctctcag atctgctggc tgtggtacag ctgtccctcc aggctgacct   3780

cagcgttcgc ctagacatct gtcgccagct tttccacctc atctacggac agccagatgt   3840

agtgcggctt ctggcccgac aggctggctg gcaagatgtg ctgacccggc tatatgtcct   3900

ggaggctgcc acagccggca gcccccctcc gtcttcccca gagtcaccta cctcccccaa   3960

gccagcccca cccaagccac ccactgagtc acctgctgag ccttcagatg tcttcctgcc   4020

ctcagaggcc ccctgccctg accctgatgg cttttaccat gctctctccc cattctgcac   4080

gccctttgac ctgggcctgg aacggtctag tgtaggatca ggcaacactg ctggtggtgg   4140

cggcagcagt gggactctta ctccagccag ccagcccggc actccttcgc cactggatgg   4200

gccgcggccc tttcctgctg ctcctggccg ccacagctcc agtctctcca atgtgctgga   4260

ggacggcagc ctcccggagc ccaccattag cggggatgat acctcgaaca ccagcaaccc   4320

acagcaaacc tctgaggaag agttgtgcaa tctgctcacc aacgtgctgt tctcggtgac   4380

gtggcgtggc gtggaaggca gcgatgaggc tgcctggcgg gagcgtggcc aggttttctc   4440

agtgctcacc cagctggggg cctcagccac acttgtgcgc ccaccagact gcatcaagcg   4500

cagcctcctg gagatgatgc tggagtcagc cctgaccgac atcaaagagg cccccgtggg   4560

ggtcctggcc agcctcaccc agcaagcgct ttggctgctg cgtctgctgc aggacttcct   4620

gtgtgctgaa ggccatggta accaggaact gtggagtgag aagctctttg aaggtgtatg   4680

cagcctactt gatcgcctgg gagcctggcc ccacctggcc aacggcacag ctgatctccg   4740

tgagatggcg cagattggcc tacggcttgt acttggctac atcctgctgg aagacccaca   4800

gctgcatgcc caggcctacg tgagattgca catgctgcta cagactgcag tgccagcccg   4860

ccgcgaggag gcctgctatg tgctctccaa gctggaggct gcactggggc gggtgctgaa   4920

cacctcttcc ttggagtcag ccactgatga ggcagggtcc ccacttgcag ctgcagcagc   4980

tgcagcagct gcagagcgct gctcctggct ggtgccactg gtgcgcacgc tgctagaccg   5040

tgcctatgag ccgctggggc tgcagtgggg actgccctcc ctgccaccca ccaatggcag   5100

ccccaccttc tttgaagact tccaggcttt ttgtgccaca cccgaatggc gccacttcat   5160

cgacaaacag gtacagccaa ccatgtccca gttcgaaatg gacacgtatg ctaagagcca   5220

cgaccttatg tcaggtttct ggaatgcctg ctatgacatg cttatgagca gtgggcagcg   5280

gcgccagtgg gagcgcgccc agagtcgtcg ggccttccag gagctggtgc tggaacctgc   5340

gcagaggcgg gcgcgcctgg aggggctacg ctacacggca gtgctgaagc agcaggcaac   5400

gcagcactcc atggccctgc tgcactgggg ggcgctgtgg cgccagctcg ccagcccatg   5460

tggggcctgg gcgctgaggg acactcccat cccccgctgg aaactgtcca gcgccgagac   5520

atattcacgc atgcgtctga agctggtgcc caaccatcac ttcgaccctc acctggaagc   5580

cagcgctctc cgagacaatc tgggtgaggt tcccctgaca cccaccgagg aggcctcact   5640

gcctctggca gtgaccaaag aggccaaagt gagcacccca cccgagttgc tgcaggagga   5700

ccagctcggc gaggacgagc tggctgagct ggagaccccg atggaggcag cagaactgga   5760

tgagcagcgt gagaagctgg tgctgtcggc cgagtgccag ctggtgacgg tagtggccgt   5820

ggtcccaggg ctgctggagg tcaccacaca gaatgtatac ttctacgatg gcagcactga   5880

gcgcgtggaa accgaggagg gcatcggcta tgatttccgg cgcccactgg cccagctgcg   5940

tgaggtccac ctgcggcgtt tcaacctgcg ccgttcagca cttgagctct tctttatcga   6000

tcaggccaac tacttcctca acttcccatg caaggtgggc acgaccccag tctcatctcc   6060

tagccagact cccagacccc agcctggccc catcccaccc catacccagg tacggaacca   6120

ggtgtactcg tggctcctgc gcctacggcc cccctctcaa ggctacctaa gcagccgctc   6180

cccccaggag atgctgcgtg cctcaggcct tacccagaaa tgggtacagc gtgagatatc   6240

caacttcgag tacttgatgc aactcaacac cattgcgggg cggacctaca atgacctgtc   6300

tcagtaccct gtgttcccct gggtcctgca ggactacgtg tccccaaccc tggacctcag   6360

caacccagcc gtcttccggg acctgtctaa gcccatcggt gtggtgaacc ccaagcatgc   6420

ccagctcgtg agggagaagt atgaaagctt tgaggaccca gcagggacca ttgacaagtt   6480

ccactatggc acccactact ccaatgcagc aggcgtgatg cactacctca tccgcgtgga   6540

gcccttcacc tccctgcacg tccagctgca aagtggccgc tttgactgct ccgaccggca   6600

gttccactcg gtggcggcag cctggcaggc acgcctggag agccctgccg atgtgaagga   6660

gctcatcccg gaattcttct actttcctga cttcctggag aaccagaacg gttttgacct   6720

gggctgtctc cagctgacca acgagaaggt aggcgatgtg gtgctacccc cgtgggccag   6780

ctctcctgag gacttcatcc agcagcaccg ccaggctctg gagtcggagt atgtgtctgc   6840

acacctacac gagtggatcg acctcatctt tggctacaag cagcgggggc cagccgccga   6900

ggaggccctc aatgtcttct attactgcac ctatgagggg gctgtagacc tggaccatgt   6960

gacagatgag cgggaacgga aggctctgga gggcattatc agcaactttg ggcagactcc   7020

ctgtcagctg ctgaaggagc cacatccaac tcggctctca gctgaggaag cagcccatcg   7080

ccttgcacgc ctggacacta actcacctag catcttccag cacctggacg aactcaaggc   7140

attcttcgca gaggttgtca gtgatggtgt acccctggtg ctagccctgg tcccccaccg   7200

gcagccccac tccttcatca cccagggttc cccagacctg ttggtgactg tgagtgccag   7260

tgggctgctg ggcacccaca gctggttgcc ctatgaccgc aacataagca actacttcag   7320

cttcagcaaa gaccccacca tgggcagcca caagacgcag cgactgctga gtggcccgtg   7380

ggtgccaggc agtggtgtga gtggacaagc actggcagtg gccccggatg gaaagctgct   7440

attcagcggt ggccactggg atggcagcct gcgggtgact gcactacccc gtggcaagct   7500

gttgagccag ctcagctgcc accttgatgt agtaacctgc cttgcactgg acacctgtgg   7560

catctacctc atctcaggct cccgggacac cacgtgcatg gtgtggcggc tcctgcatca   7620

gggtggtctg tcagtaggcc tggcaccaaa gcctgtgcag gtcctgtatg ggcatggggc   7680

tgcagtgagc tgtgtggcca tcagcactga acttgacatg gctgtgtctg gatctgagga   7740

tggaactgtg atcatacaca ctgtacgccg cggacagttt gtagcggcac tacggcctct   7800

gggtgccaca ttccctggac ctattttcca cctggcattg gggtccgaag gccagattgt   7860

ggtacagagc tcagcgtggg aacgtcctgg ggcccaggtc acctactcct tgcacctgta   7920

ttcagtcaat gggaagttgc gggcttcact gcccctggca gagcagccta cagccctgac   7980

ggtgacagag gactttgtgt tgctgggcac cgcccagtgc gccctgcaca tcctccaact   8040

aaacacactg ctcccggccg cgcctccctt gcccatgaag gtggccatcc gcagcgtggc   8100

cgtgaccaag gagcgcagcc acgtgctggt gggcctggag gatggcaagc tcatcgtggt   8160

ggtcgcgggg cagccctctg aggtgcgcag ca                                 8192


<210>  9296
<211>  2754
<212>  PRT
<213>  Homosapiens

<400>  9296

Met Ala Ala Ser Glu Arg Leu Tyr Glu Leu Trp Leu Leu Tyr Tyr Ala 
1               5                   10                  15      


Gln Lys Asp Leu Gly Tyr Leu Gln Gln Trp Leu Lys Ala Phe Val Gly 
            20                  25                  30          


Ala Phe Lys Lys Ser Ile Ser Leu Ser Ser Leu Glu Pro Arg Arg Pro 
        35                  40                  45              


Glu Glu Ala Gly Ala Glu Val Pro Leu Leu Pro Leu Asp Glu Leu His 
    50                  55                  60                  


Val Leu Ala Glu Gln Leu His Gln Ala Asp Leu Glu Gln Ala Leu Leu 
65                  70                  75                  80  


Leu Leu Lys Leu Phe Ile Ile Leu Cys Arg Asn Leu Glu Asn Ile Glu 
                85                  90                  95      


Ala Gly Arg Gly Gln Val Leu Val Pro Arg Val Leu Ala Leu Leu Thr 
            100                 105                 110         


Lys Leu Val Ala Glu Leu Lys Gly Cys Pro Pro Pro Gln Gly Arg Gly 
        115                 120                 125             


Thr Gln Leu Glu Asn Val Ala Leu His Ala Leu Leu Leu Cys Glu Gly 
    130                 135                 140                 


Leu Phe Asp Pro Tyr Gln Thr Trp Arg Arg Gln Arg Ser Gly Glu Val 
145                 150                 155                 160 


Ile Ser Ser Lys Glu Lys Ser Lys Tyr Lys Phe Pro Pro Ala Ala Leu 
                165                 170                 175     


Pro Gln Glu Phe Ser Ala Phe Phe Gln Glu Ser Leu Gln Asn Ala Asp 
            180                 185                 190         


His Leu Pro Pro Ile Leu Leu Leu Arg Leu Ile His Leu Phe Cys Ala 
        195                 200                 205             


Val Leu Ala Gly Gly Lys Glu Asn Gly Gln Met Ala Val Ser Asp Gly 
    210                 215                 220                 


Ser Val Lys Gly Leu Leu Ser Val Val Arg Gly Trp Ser Arg Gly Pro 
225                 230                 235                 240 


Ala Pro Asp Pro Cys Leu Val Pro Leu Ala Leu Glu Ala Leu Val Gly 
                245                 250                 255     


Ala Val His Val Leu His Ala Ser Arg Ala Pro Pro Arg Gly Pro Glu 
            260                 265                 270         


Leu Arg Ala Leu Leu Glu Ser Tyr Phe His Val Leu Asn Ala Asp Trp 
        275                 280                 285             


Pro Ala Gly Leu Ser Ser Gly Pro Glu Glu Ala Leu Val Thr Leu Arg 
    290                 295                 300                 


Val Ser Met Leu Asp Ala Ile Pro Met Met Leu Ala Cys Glu Asp Arg 
305                 310                 315                 320 


Pro Val Leu Gln Ala Thr Phe Leu Ser Asn Asn Cys Phe Glu His Leu 
                325                 330                 335     


Thr Arg Leu Ile Gln Asn Ser Lys Leu Tyr Leu Gln Ser Arg Ala Pro 
            340                 345                 350         


Pro Glu Gly Asp Ser Asp Leu Ala Thr Arg Leu Leu Thr Glu Pro Asp 
        355                 360                 365             


Val Gln Lys Val Leu Asp Gln Asp Thr Asp Ala Ile Ala Val His Val 
    370                 375                 380                 


Val Arg Val Leu Thr Cys Ile Met Ser Asp Ser Pro Ser Ala Lys Glu 
385                 390                 395                 400 


Val Phe Lys Glu Arg Ile Gly Tyr Pro His Leu Gln Glu Val Leu Gln 
                405                 410                 415     


Ser His Gly Pro Pro Thr His Arg Leu Leu Gln Glu Leu Leu Asn Met 
            420                 425                 430         


Ala Val Glu Gly Asp His Ser Met Cys Pro Pro Pro Pro Ile Arg Asn 
        435                 440                 445             


Glu Gln Pro Val Leu Val Leu Ala Gln Trp Leu Pro Ser Leu Pro Thr 
    450                 455                 460                 


Ala Glu Leu Arg Leu Phe Leu Ala Gln Arg Leu Arg Trp Leu Cys Asp 
465                 470                 475                 480 


Ser Cys Pro Ala Ser Arg Ala Thr Cys Val Gln Ala Gly Leu Val Gly 
                485                 490                 495     


Cys Leu Leu Glu Thr Leu Ser Thr Gly Leu Ala Leu Glu Ala Arg Cys 
            500                 505                 510         


Gln Glu Gln Leu Leu Ala Leu Leu Gln Ala Leu Gly Arg Val Ser Ile 
        515                 520                 525             


Arg Pro Met Glu Leu Arg His Leu Leu Arg Pro Arg Pro Gly Leu Asp 
    530                 535                 540                 


Ser Glu Pro Gly Gly Ala Glu Ala Gly Lys Ala Arg His Ala Gly Ala 
545                 550                 555                 560 


Val Ile Arg Thr Leu Ser Gly Met Ala Arg His Gln Gly Pro Ala Arg 
                565                 570                 575     


Ala Leu Arg Tyr Phe Asp Leu Thr Pro Ser Met Ala Gly Ile Met Val 
            580                 585                 590         


Pro Pro Val Gln Arg Trp Pro Gly Pro Gly Phe Thr Phe His Ala Trp 
        595                 600                 605             


Leu Cys Leu His Pro Met Asp Thr Ala Pro Thr Pro Ala Pro Thr Arg 
    610                 615                 620                 


Pro Leu Gln Arg Lys Gln Leu Tyr Ser Phe Phe Thr Ser Ser Gly Ser 
625                 630                 635                 640 


Gly Phe Glu Ala Phe Phe Thr Ala Ala Gly Thr Leu Val Val Ala Val 
                645                 650                 655     


Cys Thr Arg Lys Glu Tyr Leu Thr Met Ser Leu Pro Glu Val Ser Phe 
            660                 665                 670         


Ala Asp Ser Ala Trp His Cys Val Ala Ile Val His Val Pro Gly Arg 
        675                 680                 685             


Arg Pro Phe Ser Gln Asn Leu Val His Val Tyr Lys Asp Gly His Leu 
    690                 695                 700                 


Val Lys Thr Ala Pro Leu Arg Cys Pro Ser Leu Ser Glu Pro Phe Ser 
705                 710                 715                 720 


Ser Cys Cys Ile Gly Ser Ala Gly Tyr Arg Thr Thr Thr Thr Thr Thr 
                725                 730                 735     


Gly Leu Pro Thr Pro Pro Val Pro Ala Thr Leu Ala Tyr Thr His Pro 
            740                 745                 750         


Ala Leu Thr Arg Ser Gln Ser Val Pro Ala Ser Thr Gly Leu Gly Trp 
        755                 760                 765             


Gly Ser Gly Leu Val Ala Pro Leu Gln Glu Gly Ser Ile Asp Ser Thr 
    770                 775                 780                 


Leu Ala Gly Thr Gln Asp Thr Arg Trp Gly Ser Pro Thr Ser Leu Glu 
785                 790                 795                 800 


Gly Glu Leu Gly Ala Val Ala Ile Phe His Glu Ala Leu Gln Ala Thr 
                805                 810                 815     


Ala Leu Arg Thr Leu Cys Thr Leu Gly Pro Asn Glu Thr Ala Pro Phe 
            820                 825                 830         


Lys Pro Glu Gly Glu Leu His Glu Leu Ser Thr Arg Leu Leu Leu His 
        835                 840                 845             


Tyr Ser Pro Gln Ala Cys Lys Asn Asn Ile Cys Leu Asp Leu Ser Pro 
    850                 855                 860                 


Ser His Gly Leu Asp Gly Arg Leu Thr Gly His Arg Val Glu Thr Trp 
865                 870                 875                 880 


Asp Val Lys Asp Val Val Asn Cys Val Gly Gly Met Gly Ala Leu Leu 
                885                 890                 895     


Pro Leu Leu Glu Arg Val Ala Ala Gln Pro Lys Glu Ala Glu Ala Gly 
            900                 905                 910         


Pro Ala Glu Thr His Asp Leu Val Gly Pro Glu Leu Thr Ser Gly His 
        915                 920                 925             


Asn Thr Gln Gly Leu Val Leu Pro Leu Gly Lys Ser Ser Glu Glu Arg 
    930                 935                 940                 


Met Glu Arg Asn Ala Val Ala Ala Phe Leu Leu Met Leu Arg Asn Phe 
945                 950                 955                 960 


Leu Gln Gly His Met Val Asn Gln Glu Ser Leu Val Gln Cys Gln Gly 
                965                 970                 975     


Pro Ala Ile Ile Gly Ala Leu Leu Arg Lys Val Pro Ser Trp Ala Met 
            980                 985                 990         


Asp Met Asn Val Leu Met Ser Ala  Gln Leu Leu Met Glu  Gln Val Ala 
        995                 1000                 1005             


Ala Glu  Gly Ser Gly Pro Leu  Leu Tyr Leu Leu Tyr  Gln His Leu 
    1010                 1015                 1020             


Leu Phe  Asn Phe His Leu Trp  Thr Leu Ser Asp Phe  Ala Val Arg 
    1025                 1030                 1035             


Leu Gly  His Ile Gln Tyr Met  Ser Ser Ile Val Arg  Glu His Arg 
    1040                 1045                 1050             


Gln Lys  Leu Arg Lys Lys Tyr  Gly Val Gln Phe Ile  Leu Asp Ala 
    1055                 1060                 1065             


Leu Arg  Thr His Tyr Ser Pro  Gln Arg Glu Arg Pro  Leu Ala Ala 
    1070                 1075                 1080             


Asp Asp  Leu Arg Thr Val Gln  Thr Ser Leu Leu Gly  Leu Ala Arg 
    1085                 1090                 1095             


Glu Phe  Leu Val Arg Ser Leu  Ser Ala Asp Asp Val  Gln Val Thr 
    1100                 1105                 1110             


Gln Thr  Met Leu Ser Phe Leu  Ala Ala Thr Gly Asp  Asp Gly Gln 
    1115                 1120                 1125             


Ala Val  Gly Ala Leu Asp Leu  Leu Leu Ala Leu Leu  His Gly Ser 
    1130                 1135                 1140             


Leu Val  Gln Glu Ser Leu Ala  Val Phe Leu Leu Glu  Pro Gly Asn 
    1145                 1150                 1155             


Leu Glu  Val Leu Leu Ala Leu  Leu Val Arg Pro Gly  Ser Leu Pro 
    1160                 1165                 1170             


Leu Leu  Pro Asp Arg Val Cys  Lys Ile Leu Arg Arg  Leu Gln Gln 
    1175                 1180                 1185             


Asn Glu  Arg Leu Pro Glu Arg  Ser Arg Gln Arg Leu  Arg Leu Arg 
    1190                 1195                 1200             


Glu Cys  Gly Leu Gln Gly Leu  Val Ala Cys Leu Pro  Glu Gly Thr 
    1205                 1210                 1215             


Val Ser  Pro Gln Leu Cys Gln  Gly Leu Tyr Lys Leu  Phe Leu Gly 
    1220                 1225                 1230             


Ala Asp  Cys Leu Asn Leu Ser  Asp Leu Leu Ala Val  Val Gln Leu 
    1235                 1240                 1245             


Ser Leu  Gln Ala Asp Leu Ser  Val Arg Leu Asp Ile  Cys Arg Gln 
    1250                 1255                 1260             


Leu Phe  His Leu Ile Tyr Gly  Gln Pro Asp Val Val  Arg Leu Leu 
    1265                 1270                 1275             


Ala Arg  Gln Ala Gly Trp Gln  Asp Val Leu Thr Arg  Leu Tyr Val 
    1280                 1285                 1290             


Leu Glu  Ala Ala Thr Ala Gly  Ser Pro Pro Pro Ser  Ser Pro Glu 
    1295                 1300                 1305             


Ser Pro  Thr Ser Pro Lys Pro  Ala Pro Pro Lys Pro  Pro Thr Glu 
    1310                 1315                 1320             


Ser Pro  Ala Glu Pro Ser Asp  Val Phe Leu Pro Ser  Glu Ala Pro 
    1325                 1330                 1335             


Cys Pro  Asp Pro Asp Gly Phe  Tyr His Ala Leu Ser  Pro Phe Cys 
    1340                 1345                 1350             


Thr Pro  Phe Asp Leu Gly Leu  Glu Arg Ser Ser Val  Gly Ser Gly 
    1355                 1360                 1365             


Asn Thr  Ala Gly Gly Gly Gly  Ser Ser Gly Thr Leu  Thr Pro Ala 
    1370                 1375                 1380             


Ser Gln  Pro Gly Thr Pro Ser  Pro Leu Asp Gly Pro  Arg Pro Phe 
    1385                 1390                 1395             


Pro Ala  Ala Pro Gly Arg His  Ser Ser Ser Leu Ser  Asn Val Leu 
    1400                 1405                 1410             


Glu Asp  Gly Ser Leu Pro Glu  Pro Thr Ile Ser Gly  Asp Asp Thr 
    1415                 1420                 1425             


Ser Asn  Thr Ser Asn Pro Gln  Gln Thr Ser Glu Glu  Glu Leu Cys 
    1430                 1435                 1440             


Asn Leu  Leu Thr Asn Val Leu  Phe Ser Val Thr Trp  Arg Gly Val 
    1445                 1450                 1455             


Glu Gly  Ser Asp Glu Ala Ala  Trp Arg Glu Arg Gly  Gln Val Phe 
    1460                 1465                 1470             


Ser Val  Leu Thr Gln Leu Gly  Ala Ser Ala Thr Leu  Val Arg Pro 
    1475                 1480                 1485             


Pro Asp  Cys Ile Lys Arg Ser  Leu Leu Glu Met Met  Leu Glu Ser 
    1490                 1495                 1500             


Ala Leu  Thr Asp Ile Lys Glu  Ala Pro Val Gly Val  Leu Ala Ser 
    1505                 1510                 1515             


Leu Thr  Gln Gln Ala Leu Trp  Leu Leu Arg Leu Leu  Gln Asp Phe 
    1520                 1525                 1530             


Leu Cys  Ala Glu Gly His Gly  Asn Gln Glu Leu Trp  Ser Glu Lys 
    1535                 1540                 1545             


Leu Phe  Glu Gly Val Cys Ser  Leu Leu Asp Arg Leu  Gly Ala Trp 
    1550                 1555                 1560             


Pro His  Leu Ala Asn Gly Thr  Ala Asp Leu Arg Glu  Met Ala Gln 
    1565                 1570                 1575             


Ile Gly  Leu Arg Leu Val Leu  Gly Tyr Ile Leu Leu  Glu Asp Pro 
    1580                 1585                 1590             


Gln Leu  His Ala Gln Ala Tyr  Val Arg Leu His Met  Leu Leu Gln 
    1595                 1600                 1605             


Thr Ala  Val Pro Ala Arg Arg  Glu Glu Ala Cys Tyr  Val Leu Ser 
    1610                 1615                 1620             


Lys Leu  Glu Ala Ala Leu Gly  Arg Val Leu Asn Thr  Ser Ser Leu 
    1625                 1630                 1635             


Glu Ser  Ala Thr Asp Glu Ala  Gly Ser Pro Leu Ala  Ala Ala Ala 
    1640                 1645                 1650             


Ala Ala  Ala Ala Ala Glu Arg  Cys Ser Trp Leu Val  Pro Leu Val 
    1655                 1660                 1665             


Arg Thr  Leu Leu Asp Arg Ala  Tyr Glu Pro Leu Gly  Leu Gln Trp 
    1670                 1675                 1680             


Gly Leu  Pro Ser Leu Pro Pro  Thr Asn Gly Ser Pro  Thr Phe Phe 
    1685                 1690                 1695             


Glu Asp  Phe Gln Ala Phe Cys  Ala Thr Pro Glu Trp  Arg His Phe 
    1700                 1705                 1710             


Ile Asp  Lys Gln Val Gln Pro  Thr Met Ser Gln Phe  Glu Met Asp 
    1715                 1720                 1725             


Thr Tyr  Ala Lys Ser His Asp  Leu Met Ser Gly Phe  Trp Asn Ala 
    1730                 1735                 1740             


Cys Tyr  Asp Met Leu Met Ser  Ser Gly Gln Arg Arg  Gln Trp Glu 
    1745                 1750                 1755             


Arg Ala  Gln Ser Arg Arg Ala  Phe Gln Glu Leu Val  Leu Glu Pro 
    1760                 1765                 1770             


Ala Gln  Arg Arg Ala Arg Leu  Glu Gly Leu Arg Tyr  Thr Ala Val 
    1775                 1780                 1785             


Leu Lys  Gln Gln Ala Thr Gln  His Ser Met Ala Leu  Leu His Trp 
    1790                 1795                 1800             


Gly Ala  Leu Trp Arg Gln Leu  Ala Ser Pro Cys Gly  Ala Trp Ala 
    1805                 1810                 1815             


Leu Arg  Asp Thr Pro Ile Pro  Arg Trp Lys Leu Ser  Ser Ala Glu 
    1820                 1825                 1830             


Thr Tyr  Ser Arg Met Arg Leu  Lys Leu Val Pro Asn  His His Phe 
    1835                 1840                 1845             


Asp Pro  His Leu Glu Ala Ser  Ala Leu Arg Asp Asn  Leu Gly Glu 
    1850                 1855                 1860             


Val Pro  Leu Thr Pro Thr Glu  Glu Ala Ser Leu Pro  Leu Ala Val 
    1865                 1870                 1875             


Thr Lys  Glu Ala Lys Val Ser  Thr Pro Pro Glu Leu  Leu Gln Glu 
    1880                 1885                 1890             


Asp Gln  Leu Gly Glu Asp Glu  Leu Ala Glu Leu Glu  Thr Pro Met 
    1895                 1900                 1905             


Glu Ala  Ala Glu Leu Asp Glu  Gln Arg Glu Lys Leu  Val Leu Ser 
    1910                 1915                 1920             


Ala Glu  Cys Gln Leu Val Thr  Val Val Ala Val Val  Pro Gly Leu 
    1925                 1930                 1935             


Leu Glu  Val Thr Thr Gln Asn  Val Tyr Phe Tyr Asp  Gly Ser Thr 
    1940                 1945                 1950             


Glu Arg  Val Glu Thr Glu Glu  Gly Ile Gly Tyr Asp  Phe Arg Arg 
    1955                 1960                 1965             


Pro Leu  Ala Gln Leu Arg Glu  Val His Leu Arg Arg  Phe Asn Leu 
    1970                 1975                 1980             


Arg Arg  Ser Ala Leu Glu Leu  Phe Phe Ile Asp Gln  Ala Asn Tyr 
    1985                 1990                 1995             


Phe Leu  Asn Phe Pro Cys Lys  Val Gly Thr Thr Pro  Val Ser Ser 
    2000                 2005                 2010             


Pro Ser  Gln Thr Pro Arg Pro  Gln Pro Gly Pro Ile  Pro Pro His 
    2015                 2020                 2025             


Thr Gln  Val Arg Asn Gln Val  Tyr Ser Trp Leu Leu  Arg Leu Arg 
    2030                 2035                 2040             


Pro Pro  Ser Gln Gly Tyr Leu  Ser Ser Arg Ser Pro  Gln Glu Met 
    2045                 2050                 2055             


Leu Arg  Ala Ser Gly Leu Thr  Gln Lys Trp Val Gln  Arg Glu Ile 
    2060                 2065                 2070             


Ser Asn  Phe Glu Tyr Leu Met  Gln Leu Asn Thr Ile  Ala Gly Arg 
    2075                 2080                 2085             


Thr Tyr  Asn Asp Leu Ser Gln  Tyr Pro Val Phe Pro  Trp Val Leu 
    2090                 2095                 2100             


Gln Asp  Tyr Val Ser Pro Thr  Leu Asp Leu Ser Asn  Pro Ala Val 
    2105                 2110                 2115             


Phe Arg  Asp Leu Ser Lys Pro  Ile Gly Val Val Asn  Pro Lys His 
    2120                 2125                 2130             


Ala Gln  Leu Val Arg Glu Lys  Tyr Glu Ser Phe Glu  Asp Pro Ala 
    2135                 2140                 2145             


Gly Thr  Ile Asp Lys Phe His  Tyr Gly Thr His Tyr  Ser Asn Ala 
    2150                 2155                 2160             


Ala Gly  Val Met His Tyr Leu  Ile Arg Val Glu Pro  Phe Thr Ser 
    2165                 2170                 2175             


Leu His  Val Gln Leu Gln Ser  Gly Arg Phe Asp Cys  Ser Asp Arg 
    2180                 2185                 2190             


Gln Phe  His Ser Val Ala Ala  Ala Trp Gln Ala Arg  Leu Glu Ser 
    2195                 2200                 2205             


Pro Ala  Asp Val Lys Glu Leu  Ile Pro Glu Phe Phe  Tyr Phe Pro 
    2210                 2215                 2220             


Asp Phe  Leu Glu Asn Gln Asn  Gly Phe Asp Leu Gly  Cys Leu Gln 
    2225                 2230                 2235             


Leu Thr  Asn Glu Lys Val Gly  Asp Val Val Leu Pro  Pro Trp Ala 
    2240                 2245                 2250             


Ser Ser  Pro Glu Asp Phe Ile  Gln Gln His Arg Gln  Ala Leu Glu 
    2255                 2260                 2265             


Ser Glu  Tyr Val Ser Ala His  Leu His Glu Trp Ile  Asp Leu Ile 
    2270                 2275                 2280             


Phe Gly  Tyr Lys Gln Arg Gly  Pro Ala Ala Glu Glu  Ala Leu Asn 
    2285                 2290                 2295             


Val Phe  Tyr Tyr Cys Thr Tyr  Glu Gly Ala Val Asp  Leu Asp His 
    2300                 2305                 2310             


Val Thr  Asp Glu Arg Glu Arg  Lys Ala Leu Glu Gly  Ile Ile Ser 
    2315                 2320                 2325             


Asn Phe  Gly Gln Thr Pro Cys  Gln Leu Leu Lys Glu  Pro His Pro 
    2330                 2335                 2340             


Thr Arg  Leu Ser Ala Glu Glu  Ala Ala His Arg Leu  Ala Arg Leu 
    2345                 2350                 2355             


Asp Thr  Asn Ser Pro Ser Ile  Phe Gln His Leu Asp  Glu Leu Lys 
    2360                 2365                 2370             


Ala Phe  Phe Ala Glu Val Val  Ser Asp Gly Val Pro  Leu Val Leu 
    2375                 2380                 2385             


Ala Leu  Val Pro His Arg Gln  Pro His Ser Phe Ile  Thr Gln Gly 
    2390                 2395                 2400             


Ser Pro  Asp Leu Leu Val Thr  Val Ser Ala Ser Gly  Leu Leu Gly 
    2405                 2410                 2415             


Thr His  Ser Trp Leu Pro Tyr  Asp Arg Asn Ile Ser  Asn Tyr Phe 
    2420                 2425                 2430             


Ser Phe  Ser Lys Asp Pro Thr  Met Gly Ser His Lys  Thr Gln Arg 
    2435                 2440                 2445             


Leu Leu  Ser Gly Pro Trp Val  Pro Gly Ser Gly Val  Ser Gly Gln 
    2450                 2455                 2460             


Ala Leu  Ala Val Ala Pro Asp  Gly Lys Leu Leu Phe  Ser Gly Gly 
    2465                 2470                 2475             


His Trp  Asp Gly Ser Leu Arg  Val Thr Ala Leu Pro  Arg Gly Lys 
    2480                 2485                 2490             


Leu Leu  Ser Gln Leu Ser Cys  His Leu Asp Val Val  Thr Cys Leu 
    2495                 2500                 2505             


Ala Leu  Asp Thr Cys Gly Ile  Tyr Leu Ile Ser Gly  Ser Arg Asp 
    2510                 2515                 2520             


Thr Thr  Cys Met Val Trp Arg  Leu Leu His Gln Gly  Gly Leu Ser 
    2525                 2530                 2535             


Val Gly  Leu Ala Pro Lys Pro  Val Gln Val Leu Tyr  Gly His Gly 
    2540                 2545                 2550             


Ala Ala  Val Ser Cys Val Ala  Ile Ser Thr Glu Leu  Asp Met Ala 
    2555                 2560                 2565             


Val Ser  Gly Ser Glu Asp Gly  Thr Val Ile Ile His  Thr Val Arg 
    2570                 2575                 2580             


Arg Gly  Gln Phe Val Ala Ala  Leu Arg Pro Leu Gly  Ala Thr Phe 
    2585                 2590                 2595             


Pro Gly  Pro Ile Phe His Leu  Ala Leu Gly Ser Glu  Gly Gln Ile 
    2600                 2605                 2610             


Val Val  Gln Ser Ser Ala Trp  Glu Arg Pro Gly Ala  Gln Val Thr 
    2615                 2620                 2625             


Tyr Ser  Leu His Leu Tyr Ser  Val Asn Gly Lys Leu  Arg Ala Ser 
    2630                 2635                 2640             


Leu Pro  Leu Ala Glu Gln Pro  Thr Ala Leu Thr Val  Thr Glu Asp 
    2645                 2650                 2655             


Phe Val  Leu Leu Gly Thr Ala  Gln Cys Ala Leu His  Ile Leu Gln 
    2660                 2665                 2670             


Leu Asn  Thr Leu Leu Pro Ala  Ala Pro Pro Leu Pro  Met Lys Val 
    2675                 2680                 2685             


Ala Ile  Arg Ser Val Ala Val  Thr Lys Glu Arg Ser  His Val Leu 
    2690                 2695                 2700             


Val Gly  Leu Glu Asp Gly Lys  Leu Ile Val Val Val  Ala Gly Gln 
    2705                 2710                 2715             


Pro Ser  Glu Val Arg Ser Ser  Gln Phe Ala Arg Lys  Leu Trp Arg 
    2720                 2725                 2730             


Ser Ser  Arg Arg Ile Ser Gln  Val Ser Ser Gly Glu  Thr Glu Tyr 
    2735                 2740                 2745             


Asn Pro  Thr Glu Ala Arg 
    2750                 


<210>  9297
<211>  2081
<212>  DNA
<213>  Homosapiens

<400>  9297
aaagttttcc tggcagcgcc tagacctggg cttagccact gcccctcttg cccatggaac     60

cagctctggg gcctggggtc cagaaggacc tgggttacct gcagcagtgg ctgaaggcct    120

ttgtaggtgc cttcaagaag agcatctcac tgtcctctct ggagccacga aggccagagg    180

aggcaggtgc agaggtcccg ctgctaccac tggatgagct gcatgtgctg gccgaacagc    240

tgcaccaggc tgacctggag caagccctcc tgctgctcaa gctcttcatc attctctgca    300

ggaacctgga gaacatagag gcaggccggg gccaagtgct agtgccccga gtgctggcac    360

tgttgaccaa gttggtggcg gagctgaaag gatgcccacc accccagggc cgaggcacgc    420

agttggagaa tgtggcccta catgctctgc ttctctgcga gggcctcttt gacccttacc    480

aaacctggcg gcgccagcgc agtggggaag tcatcagctc caaggagaag agcaaataca    540

agttccctcc tgctgctttg ccccaggaat tcagcgcctt cttccaagag agcctacaga    600

atgcagacca cttgcctccc atactgctgt tacgtctcat ccacctcttc tgcgccgtcc    660

tcgctggagg aaaggagaac gggcagatgg ctgtaagtga tggctctgtg aagggcctgc    720

tgagtgtggt gcggggctgg agccgtgggc cagccccgga cccgtgccta gtgccactgg    780

ctctagaggc actggtaggt gcagtccatg tcttgcatgc cagccgcgca cctcctcgtg    840

gcccagagct tcgtgccctg cttgagagct acttccatgt ccttaatgct gactggccag    900

ctggtctgag ctcaggcccc gaagaggccc ttgtcaccct ccgggtcagc atgctcgacg    960

ccatccccat gatgctggca tgtgaagacc ggccagtgct gcaagccacc ttcctcagca   1020

acaattgctt tgaacacctc actcggctca ttcagaacag caaggtcctg gaccaagaca   1080

cagacgccat tgcagtccat gtagtcagag tgctgacctg catcatgagt gactccccct   1140

cggccaagga ggtgtttaag gagcgcatcg gctaccctca cctgcaggag gttctgcaga   1200

gccatggtcc ccccacccat cggctgttgc aagagctgct caacatggct gtggagggtg   1260

accacagcat gtgcccacct ccaccaatcc gcaacgagca gccggtactg gtgctggcgc   1320

agtggctgcc gtcattgccc accgctgagc tgcggctctt cctagcgcaa cgcctcaggt   1380

ggctctgtga cagctgccct gccagccgtg ccacctgtgt gcaggcaggc ctggtgggct   1440

gcctgttgga gacactcagc acagggctag ccctggaggc ccgctgccaa gagcagctgc   1500

tggcactgct acaagcactg ggccgtgtat caataaggcc catggagctg cgtcacctgc   1560

tgcgcccccg gccaggattg gactcggaac caggcggagc tgaggctgga aaggcccgac   1620

acgcaggtgc tgtcatccgc acattatcag gcatggccag gcaccagggt cctgcacgtg   1680

ctctgcgcta ctttgacctc acgcccagca tggcgggcat catggtaccc cctgtacagc   1740

gatggccagg gcctggcttc acctttcatg cctggctctg tctgcaccct atggatacag   1800

cacctacccc tgcccccacc ctgcccagct cagggattgg cgggcgatgt taccccctca   1860

gggattggcg ggcggaagtc ccgcccctcg ccggctgagg ggccgccctg agggccagca   1920

ctggcgtctg cggccgcagc agcacttttt gcacagtctg gggcggggtt ccccggcttc   1980

caagtcgctg tttcgtcaaa gcacgagggc cgcctgtggc cttaattcct aacggcggcc   2040

ccggttctcc cttctcggca ataaaccagg cctagttttg t                       2081


<210>  9298
<211>  614
<212>  PRT
<213>  Homosapiens

<400>  9298

Met Glu Pro Ala Leu Gly Pro Gly Val Gln Lys Asp Leu Gly Tyr Leu 
1               5                   10                  15      


Gln Gln Trp Leu Lys Ala Phe Val Gly Ala Phe Lys Lys Ser Ile Ser 
            20                  25                  30          


Leu Ser Ser Leu Glu Pro Arg Arg Pro Glu Glu Ala Gly Ala Glu Val 
        35                  40                  45              


Pro Leu Leu Pro Leu Asp Glu Leu His Val Leu Ala Glu Gln Leu His 
    50                  55                  60                  


Gln Ala Asp Leu Glu Gln Ala Leu Leu Leu Leu Lys Leu Phe Ile Ile 
65                  70                  75                  80  


Leu Cys Arg Asn Leu Glu Asn Ile Glu Ala Gly Arg Gly Gln Val Leu 
                85                  90                  95      


Val Pro Arg Val Leu Ala Leu Leu Thr Lys Leu Val Ala Glu Leu Lys 
            100                 105                 110         


Gly Cys Pro Pro Pro Gln Gly Arg Gly Thr Gln Leu Glu Asn Val Ala 
        115                 120                 125             


Leu His Ala Leu Leu Leu Cys Glu Gly Leu Phe Asp Pro Tyr Gln Thr 
    130                 135                 140                 


Trp Arg Arg Gln Arg Ser Gly Glu Val Ile Ser Ser Lys Glu Lys Ser 
145                 150                 155                 160 


Lys Tyr Lys Phe Pro Pro Ala Ala Leu Pro Gln Glu Phe Ser Ala Phe 
                165                 170                 175     


Phe Gln Glu Ser Leu Gln Asn Ala Asp His Leu Pro Pro Ile Leu Leu 
            180                 185                 190         


Leu Arg Leu Ile His Leu Phe Cys Ala Val Leu Ala Gly Gly Lys Glu 
        195                 200                 205             


Asn Gly Gln Met Ala Val Ser Asp Gly Ser Val Lys Gly Leu Leu Ser 
    210                 215                 220                 


Val Val Arg Gly Trp Ser Arg Gly Pro Ala Pro Asp Pro Cys Leu Val 
225                 230                 235                 240 


Pro Leu Ala Leu Glu Ala Leu Val Gly Ala Val His Val Leu His Ala 
                245                 250                 255     


Ser Arg Ala Pro Pro Arg Gly Pro Glu Leu Arg Ala Leu Leu Glu Ser 
            260                 265                 270         


Tyr Phe His Val Leu Asn Ala Asp Trp Pro Ala Gly Leu Ser Ser Gly 
        275                 280                 285             


Pro Glu Glu Ala Leu Val Thr Leu Arg Val Ser Met Leu Asp Ala Ile 
    290                 295                 300                 


Pro Met Met Leu Ala Cys Glu Asp Arg Pro Val Leu Gln Ala Thr Phe 
305                 310                 315                 320 


Leu Ser Asn Asn Cys Phe Glu His Leu Thr Arg Leu Ile Gln Asn Ser 
                325                 330                 335     


Lys Val Leu Asp Gln Asp Thr Asp Ala Ile Ala Val His Val Val Arg 
            340                 345                 350         


Val Leu Thr Cys Ile Met Ser Asp Ser Pro Ser Ala Lys Glu Val Phe 
        355                 360                 365             


Lys Glu Arg Ile Gly Tyr Pro His Leu Gln Glu Val Leu Gln Ser His 
    370                 375                 380                 


Gly Pro Pro Thr His Arg Leu Leu Gln Glu Leu Leu Asn Met Ala Val 
385                 390                 395                 400 


Glu Gly Asp His Ser Met Cys Pro Pro Pro Pro Ile Arg Asn Glu Gln 
                405                 410                 415     


Pro Val Leu Val Leu Ala Gln Trp Leu Pro Ser Leu Pro Thr Ala Glu 
            420                 425                 430         


Leu Arg Leu Phe Leu Ala Gln Arg Leu Arg Trp Leu Cys Asp Ser Cys 
        435                 440                 445             


Pro Ala Ser Arg Ala Thr Cys Val Gln Ala Gly Leu Val Gly Cys Leu 
    450                 455                 460                 


Leu Glu Thr Leu Ser Thr Gly Leu Ala Leu Glu Ala Arg Cys Gln Glu 
465                 470                 475                 480 


Gln Leu Leu Ala Leu Leu Gln Ala Leu Gly Arg Val Ser Ile Arg Pro 
                485                 490                 495     


Met Glu Leu Arg His Leu Leu Arg Pro Arg Pro Gly Leu Asp Ser Glu 
            500                 505                 510         


Pro Gly Gly Ala Glu Ala Gly Lys Ala Arg His Ala Gly Ala Val Ile 
        515                 520                 525             


Arg Thr Leu Ser Gly Met Ala Arg His Gln Gly Pro Ala Arg Ala Leu 
    530                 535                 540                 


Arg Tyr Phe Asp Leu Thr Pro Ser Met Ala Gly Ile Met Val Pro Pro 
545                 550                 555                 560 


Val Gln Arg Trp Pro Gly Pro Gly Phe Thr Phe His Ala Trp Leu Cys 
                565                 570                 575     


Leu His Pro Met Asp Thr Ala Pro Thr Pro Ala Pro Thr Leu Pro Ser 
            580                 585                 590         


Ser Gly Ile Gly Gly Arg Cys Tyr Pro Leu Arg Asp Trp Arg Ala Glu 
        595                 600                 605             


Val Pro Pro Leu Ala Gly 
    610                 


<210>  9299
<211>  6513
<212>  DNA
<213>  Homosapiens

<400>  9299
ggcccatgga gctgcgtcac ctgctgcgcc cccggccagg attggactcg gaaccaggcg     60

gagctgaggc tggaaaggcc cgacacgcag gtgctgtcat ccgcacatta tcaggcatgg    120

ccaggcacca gggtcctgca cgtgctctgc gctactttga cctcacgccc agcatggcgg    180

gcatcatggt accccctgta cagcgatggc cagggcctgg cttcaccttt catgcctggc    240

tctgtctgca ccctatggat acagcaccta cccctgcccc cacccgacca ctccagcgaa    300

agcagctgta cagcttcttt accagcagcg gctcagggtt tgaggccttc ttcacggcgg    360

ccgggaccct ggtggtggct gtgtgcacac ggaaggagta tttgaccatg agtttgcccg    420

aagtgtcctt tgccgactct gcctggcact gcgtggctat cgtccatgtg cctgggcgcc    480

ggcccttcag ccagaacctg gtccatgtct acaaagacgg ccatctggtc aagacagcac    540

cccttcgctg cccctccctc agtgagcctt tctcctcctg ctgtatcggc tccgctggat    600

accgcacaac gaccaccacc acagggctgc ccacaccacc agtccccgcc accctggcct    660

acactcaccc cgccctcacc cgctcccagt cagtcccagc ctccacaggg cttggctggg    720

ggtccgggct ggtggccccc ctgcaggagg gcagcatcga ctctaccctc gcaggcaccc    780

aggacactcg gtggggcagc cccacatccc tggagggtga gctgggggct gtggccatct    840

ttcacgaagc cctgcaggcg acggctctga ggaccctgtg caccctgggg cccaatgaga    900

cggcaccctt caagcctgag ggggagctgc atgagctcag caccaggctg ctcctccatt    960

actcacctca ggcttgtaag aacaacatct gcctggacct gtcccccagt catgggcttg   1020

atgggcgcct gacgggccac agagtggaga cctgggatgt gaaggatgtg gtgaactgcg   1080

ttgggggtat gggtgccctg ctgcccctgc tggagcgagt agctgcacag cccaaagagg   1140

ctgaagcagg tccagctgaa acgcatgacc tcgtgggtcc tgaactgacc tctggtcaca   1200

acacccaggg cctggttctc ccattgggta aatcttcaga ggaacggatg gagaggaacg   1260

cagtggctgc ttttctgctg atgctgcgga acttccttca gggtcacatg gtgaaccaag   1320

agagcctggt gcagtgccag gggcctgcca tcatcggggc cctcctgcga aaggtcccaa   1380

gctgggccat ggacatgaac gtgctcatgt ccgcccagct gctgatggag caggtggcag   1440

ctgagggcag cgggcccctc ctgtacctac tctaccagca tttgctcttc aactttcacc   1500

tctggaccct cagtgacttc gccgtgcgcc tcggtcacat ccagtacatg tccagcatag   1560

ttcgggagca cagacagaag ctgcggaaga agtacggcgt ccagtttatc ttggatgctc   1620

tgcgcaccca ctacagcccg cagcgggagc gccccctggc tgctgacgac ctacgcaccg   1680

tgcagacctc cctcctgggc ctggcgaggg agttcctggt gcggagtctc tcagcagatg   1740

acgtgcaggt cacgcagacc atgctgagct ttttggcggc cacaggcgat gacggtcaga   1800

tcctgcgcag actgcagcag aatgagcggc tacctgagcg gagccgccag cgcctccggc   1860

tgcgggagtg tggtctccag ggtctggttg cctgcttgcc tgaggggact gtttcccccc   1920

agctctgcca gggcctctac aagctgttcc tgggggcagg atcaggcaac actgctggtg   1980

gtggcggcag cagtgggact cttactccag ccagccagcc cggcactcct tcgccactgg   2040

atgggccgcg gccctttcct gctgctcctg gccgccacag ctccagtctc tccaatgtgc   2100

tggaggacgg cagcctcccg gagcccacca ttagcgggga tgatacctcg aacaccagca   2160

acccacagca aacctctgag gaagagttgt gcaatctgct caccaacgtg ctgttctcgg   2220

tgacgtggcg tggcgtggaa ggcagcgatg aggctgcctg gcgggagcgt ggccaggttt   2280

tctcagtgct cacccagctg ggggcctcag ccacacttgt gcgcccacca gactgcatca   2340

agcgcagcct cctggagatg atgctggagt cagccctgac cgacatcaaa gaggcccccg   2400

tgggggtcct ggccagcctc acccagcaag cgctttggct gctgcgtctg ctgcaggact   2460

tcctgtgtgc tgaaggccat ggtaaccagg aactgtggag tgagaagctc tttgaaggtg   2520

tatgcagcct acttgatcgc ctgggagcct ggccccacct ggccaacggc acagctgatc   2580

tccgtgagat ggcgcagatt ggcctacggc ttgtacttgg ctacatcctg ctggaagacc   2640

cacagctgca tgcccaggcc tacgtgagat tgcacatgct gctacagact gcagtgccag   2700

cccgccgcga ggaggcctgc tatgtgctct ccaagctgga ggctgcactg gggcgggtgc   2760

tgaacacctc ttccttggag tcagccactg atgaggcagg gtccccactt gcagctgcag   2820

cagctgcagc agctgcagag cgctgctcct ggctggtgcc actggtgcgc acgctgctag   2880

accgtgccta tgagccgctg gggctgcagt ggggactgcc ctccctgcca cccaccaatg   2940

gcagccccac cttctttgaa gacttccagg ctttttgtgc cacacccgaa tggcgccact   3000

tcatcgacaa acaggtacag ccaaccatgt cccagttcga aatggacacg tatgctaaga   3060

gccacgacct tatgtcaggt ttctggaatg cctgctatga catgcttatg agcagtgggc   3120

agcggcgcca gtgggagcgc gcccagagtc gtcgggcctt ccaggagctg gtgctggaac   3180

ctgcgcagag gcgggcgcgc ctggaggggc tacgctacac ggcagtgctg aagcagcagg   3240

caacgcagca ctccatggcc ctgctgcact ggggggcgct gtggcgccag ctcgccagcc   3300

catgtggggc ctgggcgctg agggacactc ccatcccccg ctggaaactg tccagcgccg   3360

agacatattc acgcatgcgt ctgaagctgg tgcccaacca tcacttcgac cctcacctgg   3420

aagccagcgc tctccgagac aatctgggtg aggttcccct gacacccacc gaggaggcct   3480

cactgcctct ggcagtgacc aaagaggcca aagtgagcac cccacccgag ttgctgcagg   3540

aggaccagct cggcgaggac gagctggctg agctggagac cccgatggag gcagcagaac   3600

tggatgagca gcgtgagaag ctggtgctgt cggccgagtg ccagctggtg acggtagtgg   3660

ccgtggtccc agggctgctg gaggtcacca cacagaatgt atacttctac gatggcagca   3720

ctgagcgcgt ggaaaccgag gagggcatcg gctatgattt ccggcgccca ctggcccagc   3780

tgcgtgaggt ccacctgcgg cgtttcaacc tgcgccgttc agcacttgag ctcttcttta   3840

tcgatcaggc caactacttc ctcaacttcc catgcaaggt gggcacgacc ccagtctcat   3900

ctcctagcca gactcccaga ccccagcctg gccccatccc accccatacc caggtacgga   3960

accaggtgta ctcgtggctc ctgcgcctac ggcccccctc tcaaggctac ctaagcagcc   4020

gctcccccca ggagatgctg cgtgcctcag gccttaccca gaaatgggta cagcgtgaga   4080

tatccaactt cgagtacttg atgcaactca acaccattgc ggggcggacc tacaatgacc   4140

tgtctcagta ccctgtgttc ccctgggtcc tgcaggacta cgtgtcccca accctggacc   4200

tcagcaaccc agccgtcttc cgggacctgt ctaagcccat cggtgtggtg aaccccaagc   4260

atgcccagct cgtgagggag aagtatgaaa gctttgagga cccagcaggg accattgaca   4320

agttccacta tggcacccac tactccaatg cagcaggcgt gatgcactac ctcatccgcg   4380

tggagccctt cacctccctg cacgtccagc tgcaaagtgg ccgctttgac tgctccgacc   4440

ggcagttcca ctcggtggcg gcagcctggc aggcacgcct ggagagccct gccgatgtga   4500

aggagctcat cccggaattc ttctactttc ctgacttcct ggagaaccag aacggttttg   4560

acctgggctg tctccagctg accaacgaga aggtaggcga tgtggtgcta cccccgtggg   4620

ccagctctcc tgaggacttc atccagcagc accgccaggc tctggagtcg gagtatgtgt   4680

ctgcacacct acacgagtgg atcgacctca tctttggcta caagcagcgg gggccagccg   4740

ccgaggaggc cctcaatgtc ttctattact gcacctatga gggggctgta gacctggacc   4800

atgtgacaga tgagcgggaa cggaaggctc tggagggcat tatcagcaac tttgggcaga   4860

ctccctgtca gctgctgaag gagccacatc caactcggct ctcagctgag gaagcagccc   4920

atcgccttgc acgcctggac actaactcac ctagcatctt ccagcacctg gacgaactca   4980

aggcattctt cgcagaggtt gtcagtgatg gtgtacccct ggtgctagcc ctggtccccc   5040

accggcagcc ccactccttc atcacccagg gttccccaga cctgttggtg actgtgagtg   5100

ccagtgggct gctgggcacc cacagctggt tgccctatga ccgcaacata agcaactact   5160

tcagcttcag caaagacccc accatgggca gccacaagac gcagcgactg ctgagtggcc   5220

cgtgggtgcc aggcagtggt gtgagtggac aagcactggc agtggccccg gatggaaagc   5280

tgctattcag cggtggccac tgggatggca gcctgcgggt gactgcacta ccccgtggca   5340

agctgttgag ccagctcagc tgccaccttg atgtagtaac ctgccttgca ctggacacct   5400

gtggcatcta cctcatctca ggctcccggg acaccacgtg catggtgtgg cggctcctgc   5460

atcagggtgg tctgtcagta ggcctggcac caaagcctgt gcaggtcctg tatgggcatg   5520

gggctgcagt gagctgtgtg gccatcagca ctgaacttga catggctgtg tctggatctg   5580

aggatggaac tgtgatcata cacactgtac gccgcggaca gtttgtagcg gcactacggc   5640

ctctgggtgc cacattccct ggacctattt tccacctggc attggggtcc gaaggccaga   5700

ttgtggtaca gagctcagcg tgggaacgtc ctggggccca ggtcacctac tccttgcacc   5760

tgtattcagt caatgggaag ttgcgggctt cactgcccct ggcagagcag cctacagccc   5820

tgacggtgac agaggacttt gtgttgctgg gcaccgccca gtgcgccctg cacatcctcc   5880

aactaaacac actgctcccg gccgcgcctc ccttgcccat gaaggtggcc atccgcagcg   5940

tggccgtgac caaggagcgc agccacgtgc tggtgggcct ggaggatggc aagctcatcg   6000

tggtggtcgc ggggcagccc tctgaggtgc gcagcagcca gttcgcgcgg aagctgtggc   6060

ggtcctcgcg gcgcatctcc caggtgtcct cgggagagac ggaatacaac cctactgagg   6120

cgcgctgaac ctggccagtc cggctgctcg ggccccgccc ccggcaggcc tggcccggga   6180

ggccccgccc agaagtcggc gggaacaccc cggggtgggc agcccagggg ggtgagcggg   6240

gcccaccctg cccagctcag ggattggcgg gcgatgttac cccctcaggg attggcgggc   6300

ggaagtcccg cccctcgccg gctgaggggc cgccctgagg gccagcactg gcgtctgcgg   6360

ccgcagcagc actttttgca cagtctgggg cggggttccc cggcttccaa gtcgctgttt   6420

cgtcaaagca cgagggccgc ctgtggcctt aattcctaac ggcggccccg gttctccctt   6480

ctcggcaata aaccaggcct agttttgtag ctg                                6513


<210>  9300
<211>  2040
<212>  PRT
<213>  Homosapiens

<400>  9300

Met Glu Leu Arg His Leu Leu Arg Pro Arg Pro Gly Leu Asp Ser Glu 
1               5                   10                  15      


Pro Gly Gly Ala Glu Ala Gly Lys Ala Arg His Ala Gly Ala Val Ile 
            20                  25                  30          


Arg Thr Leu Ser Gly Met Ala Arg His Gln Gly Pro Ala Arg Ala Leu 
        35                  40                  45              


Arg Tyr Phe Asp Leu Thr Pro Ser Met Ala Gly Ile Met Val Pro Pro 
    50                  55                  60                  


Val Gln Arg Trp Pro Gly Pro Gly Phe Thr Phe His Ala Trp Leu Cys 
65                  70                  75                  80  


Leu His Pro Met Asp Thr Ala Pro Thr Pro Ala Pro Thr Arg Pro Leu 
                85                  90                  95      


Gln Arg Lys Gln Leu Tyr Ser Phe Phe Thr Ser Ser Gly Ser Gly Phe 
            100                 105                 110         


Glu Ala Phe Phe Thr Ala Ala Gly Thr Leu Val Val Ala Val Cys Thr 
        115                 120                 125             


Arg Lys Glu Tyr Leu Thr Met Ser Leu Pro Glu Val Ser Phe Ala Asp 
    130                 135                 140                 


Ser Ala Trp His Cys Val Ala Ile Val His Val Pro Gly Arg Arg Pro 
145                 150                 155                 160 


Phe Ser Gln Asn Leu Val His Val Tyr Lys Asp Gly His Leu Val Lys 
                165                 170                 175     


Thr Ala Pro Leu Arg Cys Pro Ser Leu Ser Glu Pro Phe Ser Ser Cys 
            180                 185                 190         


Cys Ile Gly Ser Ala Gly Tyr Arg Thr Thr Thr Thr Thr Thr Gly Leu 
        195                 200                 205             


Pro Thr Pro Pro Val Pro Ala Thr Leu Ala Tyr Thr His Pro Ala Leu 
    210                 215                 220                 


Thr Arg Ser Gln Ser Val Pro Ala Ser Thr Gly Leu Gly Trp Gly Ser 
225                 230                 235                 240 


Gly Leu Val Ala Pro Leu Gln Glu Gly Ser Ile Asp Ser Thr Leu Ala 
                245                 250                 255     


Gly Thr Gln Asp Thr Arg Trp Gly Ser Pro Thr Ser Leu Glu Gly Glu 
            260                 265                 270         


Leu Gly Ala Val Ala Ile Phe His Glu Ala Leu Gln Ala Thr Ala Leu 
        275                 280                 285             


Arg Thr Leu Cys Thr Leu Gly Pro Asn Glu Thr Ala Pro Phe Lys Pro 
    290                 295                 300                 


Glu Gly Glu Leu His Glu Leu Ser Thr Arg Leu Leu Leu His Tyr Ser 
305                 310                 315                 320 


Pro Gln Ala Cys Lys Asn Asn Ile Cys Leu Asp Leu Ser Pro Ser His 
                325                 330                 335     


Gly Leu Asp Gly Arg Leu Thr Gly His Arg Val Glu Thr Trp Asp Val 
            340                 345                 350         


Lys Asp Val Val Asn Cys Val Gly Gly Met Gly Ala Leu Leu Pro Leu 
        355                 360                 365             


Leu Glu Arg Val Ala Ala Gln Pro Lys Glu Ala Glu Ala Gly Pro Ala 
    370                 375                 380                 


Glu Thr His Asp Leu Val Gly Pro Glu Leu Thr Ser Gly His Asn Thr 
385                 390                 395                 400 


Gln Gly Leu Val Leu Pro Leu Gly Lys Ser Ser Glu Glu Arg Met Glu 
                405                 410                 415     


Arg Asn Ala Val Ala Ala Phe Leu Leu Met Leu Arg Asn Phe Leu Gln 
            420                 425                 430         


Gly His Met Val Asn Gln Glu Ser Leu Val Gln Cys Gln Gly Pro Ala 
        435                 440                 445             


Ile Ile Gly Ala Leu Leu Arg Lys Val Pro Ser Trp Ala Met Asp Met 
    450                 455                 460                 


Asn Val Leu Met Ser Ala Gln Leu Leu Met Glu Gln Val Ala Ala Glu 
465                 470                 475                 480 


Gly Ser Gly Pro Leu Leu Tyr Leu Leu Tyr Gln His Leu Leu Phe Asn 
                485                 490                 495     


Phe His Leu Trp Thr Leu Ser Asp Phe Ala Val Arg Leu Gly His Ile 
            500                 505                 510         


Gln Tyr Met Ser Ser Ile Val Arg Glu His Arg Gln Lys Leu Arg Lys 
        515                 520                 525             


Lys Tyr Gly Val Gln Phe Ile Leu Asp Ala Leu Arg Thr His Tyr Ser 
    530                 535                 540                 


Pro Gln Arg Glu Arg Pro Leu Ala Ala Asp Asp Leu Arg Thr Val Gln 
545                 550                 555                 560 


Thr Ser Leu Leu Gly Leu Ala Arg Glu Phe Leu Val Arg Ser Leu Ser 
                565                 570                 575     


Ala Asp Asp Val Gln Val Thr Gln Thr Met Leu Ser Phe Leu Ala Ala 
            580                 585                 590         


Thr Gly Asp Asp Gly Gln Ile Leu Arg Arg Leu Gln Gln Asn Glu Arg 
        595                 600                 605             


Leu Pro Glu Arg Ser Arg Gln Arg Leu Arg Leu Arg Glu Cys Gly Leu 
    610                 615                 620                 


Gln Gly Leu Val Ala Cys Leu Pro Glu Gly Thr Val Ser Pro Gln Leu 
625                 630                 635                 640 


Cys Gln Gly Leu Tyr Lys Leu Phe Leu Gly Ala Gly Ser Gly Asn Thr 
                645                 650                 655     


Ala Gly Gly Gly Gly Ser Ser Gly Thr Leu Thr Pro Ala Ser Gln Pro 
            660                 665                 670         


Gly Thr Pro Ser Pro Leu Asp Gly Pro Arg Pro Phe Pro Ala Ala Pro 
        675                 680                 685             


Gly Arg His Ser Ser Ser Leu Ser Asn Val Leu Glu Asp Gly Ser Leu 
    690                 695                 700                 


Pro Glu Pro Thr Ile Ser Gly Asp Asp Thr Ser Asn Thr Ser Asn Pro 
705                 710                 715                 720 


Gln Gln Thr Ser Glu Glu Glu Leu Cys Asn Leu Leu Thr Asn Val Leu 
                725                 730                 735     


Phe Ser Val Thr Trp Arg Gly Val Glu Gly Ser Asp Glu Ala Ala Trp 
            740                 745                 750         


Arg Glu Arg Gly Gln Val Phe Ser Val Leu Thr Gln Leu Gly Ala Ser 
        755                 760                 765             


Ala Thr Leu Val Arg Pro Pro Asp Cys Ile Lys Arg Ser Leu Leu Glu 
    770                 775                 780                 


Met Met Leu Glu Ser Ala Leu Thr Asp Ile Lys Glu Ala Pro Val Gly 
785                 790                 795                 800 


Val Leu Ala Ser Leu Thr Gln Gln Ala Leu Trp Leu Leu Arg Leu Leu 
                805                 810                 815     


Gln Asp Phe Leu Cys Ala Glu Gly His Gly Asn Gln Glu Leu Trp Ser 
            820                 825                 830         


Glu Lys Leu Phe Glu Gly Val Cys Ser Leu Leu Asp Arg Leu Gly Ala 
        835                 840                 845             


Trp Pro His Leu Ala Asn Gly Thr Ala Asp Leu Arg Glu Met Ala Gln 
    850                 855                 860                 


Ile Gly Leu Arg Leu Val Leu Gly Tyr Ile Leu Leu Glu Asp Pro Gln 
865                 870                 875                 880 


Leu His Ala Gln Ala Tyr Val Arg Leu His Met Leu Leu Gln Thr Ala 
                885                 890                 895     


Val Pro Ala Arg Arg Glu Glu Ala Cys Tyr Val Leu Ser Lys Leu Glu 
            900                 905                 910         


Ala Ala Leu Gly Arg Val Leu Asn Thr Ser Ser Leu Glu Ser Ala Thr 
        915                 920                 925             


Asp Glu Ala Gly Ser Pro Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    930                 935                 940                 


Glu Arg Cys Ser Trp Leu Val Pro Leu Val Arg Thr Leu Leu Asp Arg 
945                 950                 955                 960 


Ala Tyr Glu Pro Leu Gly Leu Gln Trp Gly Leu Pro Ser Leu Pro Pro 
                965                 970                 975     


Thr Asn Gly Ser Pro Thr Phe Phe Glu Asp Phe Gln Ala Phe Cys Ala 
            980                 985                 990         


Thr Pro Glu Trp Arg His Phe Ile  Asp Lys Gln Val Gln  Pro Thr Met 
        995                 1000                 1005             


Ser Gln  Phe Glu Met Asp Thr  Tyr Ala Lys Ser His  Asp Leu Met 
    1010                 1015                 1020             


Ser Gly  Phe Trp Asn Ala Cys  Tyr Asp Met Leu Met  Ser Ser Gly 
    1025                 1030                 1035             


Gln Arg  Arg Gln Trp Glu Arg  Ala Gln Ser Arg Arg  Ala Phe Gln 
    1040                 1045                 1050             


Glu Leu  Val Leu Glu Pro Ala  Gln Arg Arg Ala Arg  Leu Glu Gly 
    1055                 1060                 1065             


Leu Arg  Tyr Thr Ala Val Leu  Lys Gln Gln Ala Thr  Gln His Ser 
    1070                 1075                 1080             


Met Ala  Leu Leu His Trp Gly  Ala Leu Trp Arg Gln  Leu Ala Ser 
    1085                 1090                 1095             


Pro Cys  Gly Ala Trp Ala Leu  Arg Asp Thr Pro Ile  Pro Arg Trp 
    1100                 1105                 1110             


Lys Leu  Ser Ser Ala Glu Thr  Tyr Ser Arg Met Arg  Leu Lys Leu 
    1115                 1120                 1125             


Val Pro  Asn His His Phe Asp  Pro His Leu Glu Ala  Ser Ala Leu 
    1130                 1135                 1140             


Arg Asp  Asn Leu Gly Glu Val  Pro Leu Thr Pro Thr  Glu Glu Ala 
    1145                 1150                 1155             


Ser Leu  Pro Leu Ala Val Thr  Lys Glu Ala Lys Val  Ser Thr Pro 
    1160                 1165                 1170             


Pro Glu  Leu Leu Gln Glu Asp  Gln Leu Gly Glu Asp  Glu Leu Ala 
    1175                 1180                 1185             


Glu Leu  Glu Thr Pro Met Glu  Ala Ala Glu Leu Asp  Glu Gln Arg 
    1190                 1195                 1200             


Glu Lys  Leu Val Leu Ser Ala  Glu Cys Gln Leu Val  Thr Val Val 
    1205                 1210                 1215             


Ala Val  Val Pro Gly Leu Leu  Glu Val Thr Thr Gln  Asn Val Tyr 
    1220                 1225                 1230             


Phe Tyr  Asp Gly Ser Thr Glu  Arg Val Glu Thr Glu  Glu Gly Ile 
    1235                 1240                 1245             


Gly Tyr  Asp Phe Arg Arg Pro  Leu Ala Gln Leu Arg  Glu Val His 
    1250                 1255                 1260             


Leu Arg  Arg Phe Asn Leu Arg  Arg Ser Ala Leu Glu  Leu Phe Phe 
    1265                 1270                 1275             


Ile Asp  Gln Ala Asn Tyr Phe  Leu Asn Phe Pro Cys  Lys Val Gly 
    1280                 1285                 1290             


Thr Thr  Pro Val Ser Ser Pro  Ser Gln Thr Pro Arg  Pro Gln Pro 
    1295                 1300                 1305             


Gly Pro  Ile Pro Pro His Thr  Gln Val Arg Asn Gln  Val Tyr Ser 
    1310                 1315                 1320             


Trp Leu  Leu Arg Leu Arg Pro  Pro Ser Gln Gly Tyr  Leu Ser Ser 
    1325                 1330                 1335             


Arg Ser  Pro Gln Glu Met Leu  Arg Ala Ser Gly Leu  Thr Gln Lys 
    1340                 1345                 1350             


Trp Val  Gln Arg Glu Ile Ser  Asn Phe Glu Tyr Leu  Met Gln Leu 
    1355                 1360                 1365             


Asn Thr  Ile Ala Gly Arg Thr  Tyr Asn Asp Leu Ser  Gln Tyr Pro 
    1370                 1375                 1380             


Val Phe  Pro Trp Val Leu Gln  Asp Tyr Val Ser Pro  Thr Leu Asp 
    1385                 1390                 1395             


Leu Ser  Asn Pro Ala Val Phe  Arg Asp Leu Ser Lys  Pro Ile Gly 
    1400                 1405                 1410             


Val Val  Asn Pro Lys His Ala  Gln Leu Val Arg Glu  Lys Tyr Glu 
    1415                 1420                 1425             


Ser Phe  Glu Asp Pro Ala Gly  Thr Ile Asp Lys Phe  His Tyr Gly 
    1430                 1435                 1440             


Thr His  Tyr Ser Asn Ala Ala  Gly Val Met His Tyr  Leu Ile Arg 
    1445                 1450                 1455             


Val Glu  Pro Phe Thr Ser Leu  His Val Gln Leu Gln  Ser Gly Arg 
    1460                 1465                 1470             


Phe Asp  Cys Ser Asp Arg Gln  Phe His Ser Val Ala  Ala Ala Trp 
    1475                 1480                 1485             


Gln Ala  Arg Leu Glu Ser Pro  Ala Asp Val Lys Glu  Leu Ile Pro 
    1490                 1495                 1500             


Glu Phe  Phe Tyr Phe Pro Asp  Phe Leu Glu Asn Gln  Asn Gly Phe 
    1505                 1510                 1515             


Asp Leu  Gly Cys Leu Gln Leu  Thr Asn Glu Lys Val  Gly Asp Val 
    1520                 1525                 1530             


Val Leu  Pro Pro Trp Ala Ser  Ser Pro Glu Asp Phe  Ile Gln Gln 
    1535                 1540                 1545             


His Arg  Gln Ala Leu Glu Ser  Glu Tyr Val Ser Ala  His Leu His 
    1550                 1555                 1560             


Glu Trp  Ile Asp Leu Ile Phe  Gly Tyr Lys Gln Arg  Gly Pro Ala 
    1565                 1570                 1575             


Ala Glu  Glu Ala Leu Asn Val  Phe Tyr Tyr Cys Thr  Tyr Glu Gly 
    1580                 1585                 1590             


Ala Val  Asp Leu Asp His Val  Thr Asp Glu Arg Glu  Arg Lys Ala 
    1595                 1600                 1605             


Leu Glu  Gly Ile Ile Ser Asn  Phe Gly Gln Thr Pro  Cys Gln Leu 
    1610                 1615                 1620             


Leu Lys  Glu Pro His Pro Thr  Arg Leu Ser Ala Glu  Glu Ala Ala 
    1625                 1630                 1635             


His Arg  Leu Ala Arg Leu Asp  Thr Asn Ser Pro Ser  Ile Phe Gln 
    1640                 1645                 1650             


His Leu  Asp Glu Leu Lys Ala  Phe Phe Ala Glu Val  Val Ser Asp 
    1655                 1660                 1665             


Gly Val  Pro Leu Val Leu Ala  Leu Val Pro His Arg  Gln Pro His 
    1670                 1675                 1680             


Ser Phe  Ile Thr Gln Gly Ser  Pro Asp Leu Leu Val  Thr Val Ser 
    1685                 1690                 1695             


Ala Ser  Gly Leu Leu Gly Thr  His Ser Trp Leu Pro  Tyr Asp Arg 
    1700                 1705                 1710             


Asn Ile  Ser Asn Tyr Phe Ser  Phe Ser Lys Asp Pro  Thr Met Gly 
    1715                 1720                 1725             


Ser His  Lys Thr Gln Arg Leu  Leu Ser Gly Pro Trp  Val Pro Gly 
    1730                 1735                 1740             


Ser Gly  Val Ser Gly Gln Ala  Leu Ala Val Ala Pro  Asp Gly Lys 
    1745                 1750                 1755             


Leu Leu  Phe Ser Gly Gly His  Trp Asp Gly Ser Leu  Arg Val Thr 
    1760                 1765                 1770             


Ala Leu  Pro Arg Gly Lys Leu  Leu Ser Gln Leu Ser  Cys His Leu 
    1775                 1780                 1785             


Asp Val  Val Thr Cys Leu Ala  Leu Asp Thr Cys Gly  Ile Tyr Leu 
    1790                 1795                 1800             


Ile Ser  Gly Ser Arg Asp Thr  Thr Cys Met Val Trp  Arg Leu Leu 
    1805                 1810                 1815             


His Gln  Gly Gly Leu Ser Val  Gly Leu Ala Pro Lys  Pro Val Gln 
    1820                 1825                 1830             


Val Leu  Tyr Gly His Gly Ala  Ala Val Ser Cys Val  Ala Ile Ser 
    1835                 1840                 1845             


Thr Glu  Leu Asp Met Ala Val  Ser Gly Ser Glu Asp  Gly Thr Val 
    1850                 1855                 1860             


Ile Ile  His Thr Val Arg Arg  Gly Gln Phe Val Ala  Ala Leu Arg 
    1865                 1870                 1875             


Pro Leu  Gly Ala Thr Phe Pro  Gly Pro Ile Phe His  Leu Ala Leu 
    1880                 1885                 1890             


Gly Ser  Glu Gly Gln Ile Val  Val Gln Ser Ser Ala  Trp Glu Arg 
    1895                 1900                 1905             


Pro Gly  Ala Gln Val Thr Tyr  Ser Leu His Leu Tyr  Ser Val Asn 
    1910                 1915                 1920             


Gly Lys  Leu Arg Ala Ser Leu  Pro Leu Ala Glu Gln  Pro Thr Ala 
    1925                 1930                 1935             


Leu Thr  Val Thr Glu Asp Phe  Val Leu Leu Gly Thr  Ala Gln Cys 
    1940                 1945                 1950             


Ala Leu  His Ile Leu Gln Leu  Asn Thr Leu Leu Pro  Ala Ala Pro 
    1955                 1960                 1965             


Pro Leu  Pro Met Lys Val Ala  Ile Arg Ser Val Ala  Val Thr Lys 
    1970                 1975                 1980             


Glu Arg  Ser His Val Leu Val  Gly Leu Glu Asp Gly  Lys Leu Ile 
    1985                 1990                 1995             


Val Val  Val Ala Gly Gln Pro  Ser Glu Val Arg Ser  Ser Gln Phe 
    2000                 2005                 2010             


Ala Arg  Lys Leu Trp Arg Ser  Ser Arg Arg Ile Ser  Gln Val Ser 
    2015                 2020                 2025             


Ser Gly  Glu Thr Glu Tyr Asn  Pro Thr Glu Ala Arg  
    2030                 2035                 2040 


<210>  9301
<211>  2074
<212>  DNA
<213>  Homosapiens

<400>  9301
gcagatggga atcctaatca aggtcactga tttcaaggca ccttagaaaa tgagctaaac     60

atgggaagag tatgggggca ggaggggtgc cttcttcatc agggccagga taaagtgtcg    120

actcaacaag ctctgaaagc cttagggaga tcaggaggga gatctgtcct tggacccctt    180

ccatcgcctt cctagacagg aacattcctg aatgttgccc ccaggcctga cttttttttt    240

aggtttccct ctcttcctgc ctttgggcta gggggacaag gaataacagg gtgagaggac    300

caagttgaaa ctaagtgtga tactctggaa gcatcttcca tgtctgtccc agcttctcac    360

ccactttctg agatgccctc ctaaagtctc tgcctgtttc ttggagggaa cctctgcatc    420

tgtgacacct actctatgac ccctggggac tgacagtaaa ggaagggatg atgcttcagg    480

gagcagatag tgtaatctga tagtactcag gcatagctag gcctgccctt gcccctgcag    540

gttgtcagtg atggtgtacc cctggtgcta gccctggtcc cccaccggca gccccactcc    600

ttcatcaccc agggttcccc agacctgttg gtgactgtga gtgccagtgg gctgctgggc    660

acccacagct ggttgcccta tgaccgcaac ataagcaact acttcagctt cagcaaagac    720

cccaccatgg gcagccacaa gtaggacaga gggctgtggg tggggtgggc tacaaatgcc    780

ctgcacccgg aattattccc ctccctaatc agaatgtagg ccagctgcag gggaaaggtc    840

tggccaggct ccctgagggc ctgggtctct tccatgtggc ctggcctcac ttgctatccc    900

cctcactggg tcaggacgca gcgactgctg agtggcccgt gggtgccagg cagtggtgtg    960

agtggacaag cactggcagt ggccccggat ggaaagctgc tattcagcgg tggccactgg   1020

gatggcagcc tgcgggtgac tgcactaccc cgtggcaagc tgttgagcca gctcagctgc   1080

caccttggta tgaacagcct tggagctggg gagaatgagg cacacaggta tggggccggg   1140

ttctgaggct ggccagggcg gatgtgactc ctccgttctg cctgtaccct ccccttccca   1200

tgcagatgta gtaacctgcc ttgcactgga cacctgtggc atctacctca tctcaggctc   1260

ccgggacacc acgtgcatgg tgtggcggct cctgcatcag gtgtgcctcg tgggcagctc   1320

tgtggggccc ccgtagccca gacctgcagc ccatccgtcc ctcagtggcc ttccagtcct   1380

gtcctcctct agtcttggac aaggccttca tttcctgagc ctcaggggac agtcctaagc   1440

caaccctggt cctccacagg gtggtctgtc agtaggcctg gcaccaaagc ctgtgcaggt   1500

cctgtatggg catggggctg cagtgagctg tgtggccatc agcactgaac ttgacatggc   1560

tgtgtctgga tctgaggtgt gtgtatgcat gtgccctggg gagggtgagt ttcctgggca   1620

atccccctgg agcccagact cctgcccagg accctaagtt gccttcctgc aggatggaac   1680

tgtgatcata cacactgtac gccgcggaca gtttgtagcg gcactacggc ctctgggtgc   1740

cacattccct ggacctattt tccacctggc attggggtcc gaaggccaga ttgtggtaca   1800

gagctcagcg tgggaacgtc ctggggccca ggtatgggga aggggtgccc agcaaagatg   1860

gaggggcagt tgggatcctg tccttgctga cactccctgc ttcctccagg tcacctactc   1920

cttgcacctg tattcagtca atgggaagtt gcgggcttca ctgcccctgg cagagcagcc   1980

tacagccctg acggtgacag aggactttgt gttgctgggc accgcccagt gcgccctgca   2040

catcctccaa ctaaacacgt aagcccccca ttta                               2074


<210>  9302
<211>  90
<212>  PRT
<213>  Homosapiens

<400>  9302

Met Trp Pro Gly Leu Thr Cys Tyr Pro Pro His Trp Val Arg Thr Gln 
1               5                   10                  15      


Arg Leu Leu Ser Gly Pro Trp Val Pro Gly Ser Gly Val Ser Gly Gln 
            20                  25                  30          


Ala Leu Ala Val Ala Pro Asp Gly Lys Leu Leu Phe Ser Gly Gly His 
        35                  40                  45              


Trp Asp Gly Ser Leu Arg Val Thr Ala Leu Pro Arg Gly Lys Leu Leu 
    50                  55                  60                  


Ser Gln Leu Ser Cys His Leu Gly Met Asn Ser Leu Gly Ala Gly Glu 
65                  70                  75                  80  


Asn Glu Ala His Arg Tyr Gly Ala Gly Phe 
                85                  90  


<210>  9303
<211>  1360
<212>  DNA
<213>  Homosapiens

<400>  9303
ccagaaaccc acctctgccc cctcctgcct gcaggtgact gtgagtgcca gtgggctgct     60

gggcacccac agctggttgc cctatgaccg caacataagc aactacttca gcttcagcaa    120

agaccccacc atgggcagcc acaagtagga cagagggctg tgggtggggt gggctacaaa    180

tgccctgcac ccggaattat tcccctccct aatcagaatg taggccagct gcaggggaaa    240

ggtctggcca ggctccctga gggcctgggt ctcttccatg tggcctggcc tcacttgcta    300

tccccctcac tgggtcagga cgcagcgact gctgagtggc ccgtgggtgc caggcagtgg    360

tgtgagtgga caagcactgg cagtggcccc ggatggaaag ctgctattca gcggtggcca    420

ctgggatggc agcctgcggg tgactgcact accccgtggc aagctgttga gccagctcag    480

ctgccacctt gatgtagtaa cctgccttgc actggacacc tgtggcatct acctcatctc    540

aggctcccgg gacaccacgt gcatggtgtg gcggctcctg catcaggtgt gcctcgtggg    600

cagctctgtg gggcccccgt agcccagacc tgcagcccat ccgtccctca gtggccttcc    660

agtcctgtcc tcctctagtc ttggacaagg ccttcatttc ctgagcctca ggggacagtc    720

ctaagccaac cctggtcctc cacagggtgg tctgtcagta ggcctggcac caaagcctgt    780

gcaggtcctg tatgggcatg gggctgcagt gagctgtgtg gccatcagca ctgaacttga    840

catggctgtg tctggatctg aggtgtgtgt atgcatgtgc cctggggagg gtgagtttcc    900

tgggcaatcc ccctggagcc cagactcctg cccaggaccc taagttgcct tcctgcagga    960

tggaactgtg atcatacaca ctgtacgccg cggacagttt gtagcggcac tacggcctct   1020

gggtgccaca ttccctggac ctattttcca cctggcattg gggtccgaag gccagattgt   1080

ggtacagagc tcagcgtggg aacgtcctgg ggcccaggta tggggaaggg gtgcccagca   1140

aagatggagg ggcagttggg atcctgtcct tgctgacact ccctgcttcc tccaggtcac   1200

ctactccttg cacctgtatt cagtcaatgg gaagttgcgg gcttcactgc ccctggcaga   1260

gcagcctaca gccctgacgg tgacagagga ctttgtgttg ctgggcaccg cccagtgcgc   1320

cctgcacatc ctccaactaa acacgtaagc cccccattta                         1360


<210>  9304
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  9304

Met Trp Pro Gly Leu Thr Cys Tyr Pro Pro His Trp Val Arg Thr Gln 
1               5                   10                  15      


Arg Leu Leu Ser Gly Pro Trp Val Pro Gly Ser Gly Val Ser Gly Gln 
            20                  25                  30          


Ala Leu Ala Val Ala Pro Asp Gly Lys Leu Leu Phe Ser Gly Gly His 
        35                  40                  45              


Trp Asp Gly Ser Leu Arg Val Thr Ala Leu Pro Arg Gly Lys Leu Leu 
    50                  55                  60                  


Ser Gln Leu Ser Cys His Leu Asp Val Val Thr Cys Leu Ala Leu Asp 
65                  70                  75                  80  


Thr Cys Gly Ile Tyr Leu Ile Ser Gly Ser Arg Asp Thr Thr Cys Met 
                85                  90                  95      


Val Trp Arg Leu Leu His Gln Val Cys Leu Val Gly Ser Ser Val Gly 
            100                 105                 110         


Pro Pro 
        


<210>  9305
<211>  805
<212>  DNA
<213>  Homosapiens

<400>  9305
ccacagggtg gtctgtcagt aggcctggca ccaaagcctg tgcaggtcct gtatgggcat     60

ggggctgcag tgagctgtgt ggccatcagc actgaacttg acatggctgt gtctggatct    120

gaggtgtgtg tatgcatgtg ccctggggag ggtgagtttc ctgggcaatc cccctggagc    180

ccagactcct gcccaggacc ctaagttgcc ttcctgcagg atggaactgt gatcatacac    240

actgtacgcc gcggacagtt tgtagcggca ctacggcctc tgggtgccac attccctgga    300

cctattttcc acctggcatt ggggtccgaa ggccagattg tggtacagag ctcagcgtgg    360

gaacgtcctg gggcccaggt atggggaagg ggtgcccagc aaagatggag gggcagttgg    420

gatcctgtcc ttgctgacac tccctgcttc ctccaggtca cctactcctt gcacctgtat    480

tcagtcaatg ggaagttgcg ggcttcactg cccctggcag agcagcctac agccctgacg    540

gtgacagagg actttgtgtt gctgggcacc gcccagtgcg ccctgcacat cctccaacta    600

aacacactgc tcccggccgc gcctcccttg cccatgaagg tggccatccg cagcgtggcc    660

gtgaccaagg agcgcagcca cgtgctggtg ggcctggagg atggcaagct catcgtggtg    720

gtcgcggggc agccctctga ggtgaggatg gggcgggggt ggggaggccc ccctcgccgg    780

ctgaggggcc gccctgaggg ccagc                                          805


<210>  9306
<211>  56
<212>  PRT
<213>  Homosapiens

<400>  9306

Met Lys Val Ala Ile Arg Ser Val Ala Val Thr Lys Glu Arg Ser His 
1               5                   10                  15      


Val Leu Val Gly Leu Glu Asp Gly Lys Leu Ile Val Val Val Ala Gly 
            20                  25                  30          


Gln Pro Ser Glu Val Arg Met Gly Arg Gly Trp Gly Gly Pro Pro Arg 
        35                  40                  45              


Arg Leu Arg Gly Arg Pro Glu Gly 
    50                  55      


<210>  9307
<211>  568
<212>  DNA
<213>  Homosapiens

<400>  9307
atccaggggc aacagatttt cacagctcat ccacaaggag tggtggtaca gccagccgca     60

gcatgattac ctagttgtga gctgttggca tgtggttaga agccatcaga ggtgcaaggg    120

cttagaaaag accctggcca gacctgactc cactcttaaa cctgggtctt ctccttggcg    180

gtgctgtcag cgcacagacc catgcgcatc cccacccaca accctttacc ctgatgatct    240

gtattatatt ttaatgtata tgtgaatata ttgaaaataa tttgtttttt cctggttttt    300

gtttggtttt cgttttgctt ttagcctcta catgctagga tcacaggaag actttgtaag    360

gacagtttaa gttctcctgc aaggtttaat ttgttatcat gtaaatattc taaagcaggc    420

tgccttgtgg ttttggccag ccttgtgcta tgttgataag attgatttac tgcttaaaat    480

cactttactt tatccaattt ttactgaact ttttatgtaa aaaaataaaa tcaattaaag    540

aacttggcat gtgtgttccc taaaagtt                                       568


<210>  9308
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  9308

Met Leu Ile Arg Leu Ile Tyr Cys Leu Lys Ser Leu Tyr Phe Ile Gln 
1               5                   10                  15      


Phe Leu Leu Asn Phe Leu Cys Lys Lys Ile Lys Ser Ile Lys Glu Leu 
            20                  25                  30          


Gly Met Cys Val Pro 
        35          


<210>  9309
<211>  7856
<212>  DNA
<213>  Homosapiens

<400>  9309
caacactctc atcaccagca ccagtaacag agccagtggc cttgccacat acaccaataa     60

cagttctaat ggcagcacca gtacccttac cagtagatgt agcagttaga tctctgaaag    120

aaccaccaat tataattgta ccagaatctt tagaagcaga tactaagcag gacactatat    180

ctaatagttt agaagaacac gtaactcaaa tattgaatga gcaagcagat atttcctcaa    240

aaaaagaaga ttcccatatt gggaaggatg aagaaattcc agatagttct aagattagtc    300

tgagctgtaa aaaaacaggt tctaagaaga aatcctcaca atctgaaggc atctttcttg    360

gttcagaatc tgatgaagat tctgtacgga cttcttcaag tcaaagatca catgatttaa    420

aattttcagc aagcattgaa aaggaaagag attttaaaaa gagctcagca cctttaaaaa    480

gtgaggatct agggaaacct tcacgatcta aaacagacag agatgataaa tattttagct    540

attcaaaact tgaaagagat actcggtatg tatcttcccg atgtagatca gaaagagagc    600

gacggcggag cagatctcac tctaggtctg agagaggctc tagaactaat ttatcctatt    660

ccaggtcaga acgatctcat tattatgact ctgatcgtcg ctaccatagg agctcccctt    720

atcgagagag gacgcgctat tctcggccat acacagataa cagagcacga gagagttctg    780

actcagaaga agagtataag aagacatact caaggcgtac ctcatctcat tcctcttctt    840

acagagacct aaggacatca tcctattcta aatctgatcg ggactgtaaa actgagacct    900

cttacttaga gatggaaaga agaggcaagt attcttcaaa actagaaaga gaatctaaaa    960

ggacttcaga aaatgaagca attaaaagat gttgttctcc ccctaatgaa ctgggattcc   1020

gacgagggtc atcatattct aagcatgaca gtagtgcttc ccgttataaa tctacccttt   1080

caaaacctat acccaagtct gataaattta aaaattcttt ctgttgtaca gaattaaatg   1140

aagaaatcaa acagtctcat tcttttagtt tacagacacc ttgttcaaaa ggtagtgaat   1200

taagaatgat taataaaaat cctgaaagag aaaaggctgg gtctccagct ccatcaaatc   1260

gattaaatga ttcacctact ttaaaaaagc tagatgaatt gcctattttt aagtccgaat   1320

ttataacaca tgatagccat gatagtatta aggaattaga ctctttatct aaagtgaaga   1380

atgatcaatt aagaagtttt tgtcccatag aattaaatat aaatggatct cctggggcag   1440

aatctgattt ggcaacattt tgcacttcta aaactgatgc tgttttaatg acttctgatg   1500

atagtgtgac tggatcggaa ttatcccctt tggtcaaagc atgcatgctt tcatcaaatg   1560

gatttcagaa tattagtagg tgcaaagaaa aagacttgga tgatacctgc atgctgcata   1620

agaagtcaga aagcccattt agagaaacag aacctctggt gtcaccacac caagataaac   1680

tcatgtctat gccagttatg actgtggatt attccaaaac agtagttaaa gaaccagttg   1740

atacgagggt ttcttgctgc aaaaccaaag attcagacat atactgtact ttgaacgata   1800

gcaacccttc tttgtgtaac tctgaagctg aaaatattga gccttcagtt atgaagattt   1860

cttcaaatag ctttatgaat gtgcatttgg aatcaaaacc agttatatgt gatagtagaa   1920

atttgacaga tcactcaaaa tttgcatgtg aagaatataa gcagagcatc ggtagcacta   1980

gttcagcttc tgttaatcat tttgatgatt tatatcaacc tattgggagt tcaggtattg   2040

cttcatctct tcagagtctt ccaccaggaa taaaggtgga cagtctaact ctcttgaaat   2100

gcggagagaa cacatctcca gttctggatg cagtgctaaa gagtaaaaaa agttcagagt   2160

ttttaaagca tgcagggaaa gaaacaatag tagaagtagg tagtgacctt cctgattcag   2220

gaaagggatt tgcttccagg gagaacaggc gtaataatgg gttatctggg aaatgtttgc   2280

aagaggctca agaagaaggg aattccatat tgcctgaaag aagaggaaga ccagaaatct   2340

ctttagatga aagaggagaa ggaggacatg tgcatacttc tgatgactca gaagttgtat   2400

tttcttcttg tgatttgaat ttaaccatgg aagacagtga tggtgtaact tatgcattaa   2460

agtgtgacag tagtggtcat gccccagaaa ttgtgtctac agttcatgaa gattattctg   2520

gctcttctga aagttcaaat gatgaaagtg attcagaaga tacagattcg gatgatagca   2580

gtattccaag aaaccgtctc cagtctgttg tggttgtgcc aaagaattct actttgccca   2640

tggaagaaac aagtccttgt tcttctcgga gcagtcaaag ttatagacac tattctgacc   2700

attgggaaga tgagagattg gagtcaagga gacatttgta tgaggaaaaa tttgaaagta   2760

tagcaagtaa agcctgtcct caaactgata agtttttcct tcataaagga acagagaaga   2820

atccggaaat ttcttttaca cagtccagta gaaaacaaat agataatcgc ctgcctgaac   2880

tttctcatcc tcagagtgat ggggttgata gtacaagtca tacagatgtg aaatctgacc   2940

ctctgggtca cccaaattca gaggaaaccg tgaaagccaa aataccttct aggcagcaag   3000

aagagctgcc aatttattct tctgattttg aagatgtccc aaataagtct tggcaacaga   3060

ccactttcca aaacaggcca gatagtagac tgggaaaaac agaattgagt ttttcttcct   3120

cttgtgagat accacatgtg gatggcttgc actcatcaga agagctcaga aacttaggtt   3180

gggacttctc tcaagaaaag ccttctacca cgtatcagca acctgacagt agctatggag   3240

cttgtggtgg acacaagtat cagcaaaatg cagaacagta tggtgggaca cgtgattact   3300

ggcaaggcaa tggttactgg gatccaagat caggtagacc tcctggaact ggggttgtgt   3360

atgatcgaac tcaaggacaa gtaccagatt ccctaacaga tgatcgtgaa gaagaggaga   3420

attgggatca acaggatgga tcccattttt cagaccagtc cgataaattt cttctatccc   3480

ttcagaaaga caaggggtca gtgcaagcac ctgaaataag cagcaattcc attaaggaca   3540

ctttagctgt gaatgaaaag aaagattttt caaaaaactt agaaaaaaat gatatcaaag   3600

atagagggcc tcttaaaaaa aggaggcagg aaatagagag tgattctgaa agtgatggtg   3660

agcttcagga cagaaagaaa gttagagtgg aggtagagca gggagagaca tcagtgcccc   3720

caggttcagc actggttggg ccctcctgtg tcatggatga cttcagggac ccacagcgat   3780

ggaaggaatg tgccaagcaa gggaaaatgc catgttactt tgatcttatt gaagaaaatg   3840

tttatttaac agaaagaaag aagaataaat ctcatcgaga tattaagcga atgcagtgtg   3900

agtgtacacc tctttctaaa gatgaaagag ctcaaggtga aatagcatgt ggggaagatt   3960

gtcttaatcg tcttctcatg attgaatgtt cttctcggtg tccaaatggg gattattgtt   4020

ccaatagacg gtttcagaga aaacagcatg cagatgtgga agtcatactc acagaaaaga   4080

aaggctgggg cttgagagct gccaaagacc ttccttcgaa cacctttgtc ctagaatatt   4140

gtggagaggt actcgatcat aaagagttta aagctcgagt gaaggagtat gcacgaaaca   4200

aaaacatcca ttactatttc atggccctga agaatgatga gataatagat gccactcaaa   4260

aaggaaattg ctctcgtttc atgaatcaca gctgtgaacc aaattgtgaa acccaaaaat   4320

ggactgtgaa cggacaactg agggttgggt tttttaccac caaactggtt ccttcaggct   4380

cagagttaac gtttgactat cagttccaga gatatggaaa agaagcccag aaatgtttct   4440

gcggatcagc caattgccgg ggttacctgg gaggagaaaa cagagtcagc atcagagcag   4500

caggagggaa aatgaagaag gaacgatctc gtaagaagga ttcagtggat ggagagctag   4560

aagctctgat ggaaaatggt gagggtctct ctgataaaaa ccaggtgctc agcttatccc   4620

ggctaatggt tagaattgaa actttggagc agaaacttac ctgtctggaa ctcatacaga   4680

acacacactc acagtcctgc ctgaagtcct ttctggaacg tcatgggctg tctttgttgt   4740

ggatctggat ggcagagcta ggtgacggcc gggaaagtaa ccagaagctt caggaagaga   4800

ttataaagac tttggaacac ttgcccattc ctactaaaaa tatgttggag gaaagcaaag   4860

tacttccaat tattcaacgc tggtctcaga ctaagactgc tgtccctccg ttgagtgaag   4920

gagatgggta ttctagtgag aatacatcgc gtgctcatac accactcaac acacctgatc   4980

cttccaccaa gctgagcaca gaagctgaca cagacactcc caagaaacta atgtttcgca   5040

gactgaaaat tataagtgaa aatagcatgg acagtgcaat ctctgatgca accagtgagc   5100

tagaaggcaa ggatggcaaa gaggatcttg atcaattaga aaatgtccct gtagaggaag   5160

aggaagaatt gcagtcacaa cagctactcc cacaacagct gcctgaatgc aaagttgata   5220

gtgaaaccaa catagaagct agtaagctac ctacatctga accagaagct gacgctgaaa   5280

tagagcccaa agagagcaac ggcacaaaac tagaagaacc tattaatgaa gaaacaccat   5340

cccaagatga agaggagggt gtgtctgatg tggagagtga aaggagccaa gaacagccag   5400

ataaaacagt ggatataagt gatttggcca ccaaactcct ggacagttgg aaagacctaa   5460

aggaggtata tcgaattcca aagaaaagtc aaactgaaaa ggaaaacaca agaaatcagc   5520

ctgaataaat ggaatgactt gtctgcctca catattctaa ggtgcagagt cagaatatga   5580

actgttgcaa ctgaacgagg aagggatgct gttggcttca gagatcaaac acctgccccg   5640

aagactccta ataggtcaag agagagagac ccagacaagc aaactcaaaa taaagagaaa   5700

aggaaacgaa gaagctccct ctcaccaccc tcttctgcct atgagcgggg aacaaaaagg   5760

ccagatgaca gatatgatac accaacttct aaaaagaaag tacgaattaa agaccgcaat   5820

aaactttcta cagaggaacg ccggaagttg tttgagcaag aggtggctca acgggaggct   5880

cagaaacaac agcaacagat gcagaacctg ggaatgacat caccactgcc ctatgactct   5940

cttggttata atgccccgca tcatcccttt gctggttacc caccaggtta tcccatgcag   6000

gcctatgtgg atcccagcaa ccctaatgct ggaaaggtgc tcctgcccac acccagcatg   6060

gacccagtgt gttctcctgc tccttatgat catgctcagc ccttggtggg acattctaca   6120

gaaccccttt ctgcccctcc accagtacca gtggtgccac atgtggcagc tcctgtggaa   6180

gtttccagtt cccagtatgt ggcccagagt gatggtgtag tacaccaaga ctccagcgtt   6240

gctgtcttgc cagtgccggc ccccggccca gttcagggac agaattatag tgtttgggat   6300

tcaaaccaac agtctgtcag tgtacagcag cagtactctc ctgcacagtc tcaagcaacc   6360

atatattatc aaggacagac atgtccaaca gtctatggtg tgacatcacc ttattcacag   6420

acaactccac caattgtaca gagttatgcc cagccaagtc ttcagtatat ccaggggcaa   6480

cagattttca cagctcatcc acaaggagtg gtggtacagc cagccgcagc agtgactaca   6540

atagttgcac cagggcagcc tcagcccttg cagccatctg aaatggttgt gacaaataat   6600

ctcttggatc tgccgccccc ctctcctccc aaaccaaaaa ccattgtctt acctcccaac   6660

tggaagacag ctcgagatcc agaagggaag atttattact accatgtgat cacaaggcag   6720

actcagtggg atcctcctac ttgggaaagc ccaggagatg atgccagcct tgagcatgaa   6780

gctgagatgg acctgggaac tccaacatat gatgaaaacc ccatgaaggc ctcgaaaaag   6840

cccaagacag cagaagcaga cacctccagt gaactagcaa agaaaagcaa agaagtattc   6900

agaaaagaga tgtcccagtt catcgtccag tgcctgaacc cttaccggaa acctgactgc   6960

aaagtgggaa gaattaccac aactgaagac tttaaacatc tggctcgcaa gctgactcac   7020

ggtgttatga ataaggagct gaagtactgt aagaatcctg aggacctgga gtgcaatgag   7080

aatgtgaaac acaaaaccaa ggagtacatt aagaagtaca tgcagaagtt tggggctgtt   7140

tacaaaccca aagaggacac tgaattagag tgactgttgg gccagggtgg gaggatgggt   7200

ggtcaggtaa gacagactct agggagagga aatcctgtgg gcctttctgt cccacccctg   7260

tcagcactgt gctactgatg atacatcacc ctggggaatt caaccctgca gatgtcaact   7320

gaaggccaca aaaatgaact ccatctacaa gtgattacct agttgtgagc tgttggcatg   7380

tggttagaag ccatcagagg tgcaagggct tagaaaagac cctggccaga cctgactcca   7440

ctcttaaacc tgggtcttct ccttggcggt gctgtcagcg cacagaccca tgcgcatccc   7500

cacccacaac cctttaccct gatgatctgt attatatttt aatgtatatg tgaatatatt   7560

gaaaataatt tgttttttcc tggtttttgt ttggttttcg ttttgctttt agcctctaca   7620

tgctaggatc acaggaagac tttgtaagga cagtttaagt tctcctgcaa ggtttaattt   7680

gttatcatgt aaatattcta aagcaggctg ccttgtggtt ttggccagcc ttgtgctatg   7740

ttgataagat tgatttactg cttaaaatca ctttacttta tccaattttt actgaacttt   7800

ttatgtaaaa aaataaaatc aattaaagaa cttggcatgt gtgttcccta aaagtt       7856


<210>  9310
<211>  1819
<212>  PRT
<213>  Homosapiens

<400>  9310

Met Ala Ala Pro Val Pro Leu Pro Val Asp Val Ala Val Arg Ser Leu 
1               5                   10                  15      


Lys Glu Pro Pro Ile Ile Ile Val Pro Glu Ser Leu Glu Ala Asp Thr 
            20                  25                  30          


Lys Gln Asp Thr Ile Ser Asn Ser Leu Glu Glu His Val Thr Gln Ile 
        35                  40                  45              


Leu Asn Glu Gln Ala Asp Ile Ser Ser Lys Lys Glu Asp Ser His Ile 
    50                  55                  60                  


Gly Lys Asp Glu Glu Ile Pro Asp Ser Ser Lys Ile Ser Leu Ser Cys 
65                  70                  75                  80  


Lys Lys Thr Gly Ser Lys Lys Lys Ser Ser Gln Ser Glu Gly Ile Phe 
                85                  90                  95      


Leu Gly Ser Glu Ser Asp Glu Asp Ser Val Arg Thr Ser Ser Ser Gln 
            100                 105                 110         


Arg Ser His Asp Leu Lys Phe Ser Ala Ser Ile Glu Lys Glu Arg Asp 
        115                 120                 125             


Phe Lys Lys Ser Ser Ala Pro Leu Lys Ser Glu Asp Leu Gly Lys Pro 
    130                 135                 140                 


Ser Arg Ser Lys Thr Asp Arg Asp Asp Lys Tyr Phe Ser Tyr Ser Lys 
145                 150                 155                 160 


Leu Glu Arg Asp Thr Arg Tyr Val Ser Ser Arg Cys Arg Ser Glu Arg 
                165                 170                 175     


Glu Arg Arg Arg Ser Arg Ser His Ser Arg Ser Glu Arg Gly Ser Arg 
            180                 185                 190         


Thr Asn Leu Ser Tyr Ser Arg Ser Glu Arg Ser His Tyr Tyr Asp Ser 
        195                 200                 205             


Asp Arg Arg Tyr His Arg Ser Ser Pro Tyr Arg Glu Arg Thr Arg Tyr 
    210                 215                 220                 


Ser Arg Pro Tyr Thr Asp Asn Arg Ala Arg Glu Ser Ser Asp Ser Glu 
225                 230                 235                 240 


Glu Glu Tyr Lys Lys Thr Tyr Ser Arg Arg Thr Ser Ser His Ser Ser 
                245                 250                 255     


Ser Tyr Arg Asp Leu Arg Thr Ser Ser Tyr Ser Lys Ser Asp Arg Asp 
            260                 265                 270         


Cys Lys Thr Glu Thr Ser Tyr Leu Glu Met Glu Arg Arg Gly Lys Tyr 
        275                 280                 285             


Ser Ser Lys Leu Glu Arg Glu Ser Lys Arg Thr Ser Glu Asn Glu Ala 
    290                 295                 300                 


Ile Lys Arg Cys Cys Ser Pro Pro Asn Glu Leu Gly Phe Arg Arg Gly 
305                 310                 315                 320 


Ser Ser Tyr Ser Lys His Asp Ser Ser Ala Ser Arg Tyr Lys Ser Thr 
                325                 330                 335     


Leu Ser Lys Pro Ile Pro Lys Ser Asp Lys Phe Lys Asn Ser Phe Cys 
            340                 345                 350         


Cys Thr Glu Leu Asn Glu Glu Ile Lys Gln Ser His Ser Phe Ser Leu 
        355                 360                 365             


Gln Thr Pro Cys Ser Lys Gly Ser Glu Leu Arg Met Ile Asn Lys Asn 
    370                 375                 380                 


Pro Glu Arg Glu Lys Ala Gly Ser Pro Ala Pro Ser Asn Arg Leu Asn 
385                 390                 395                 400 


Asp Ser Pro Thr Leu Lys Lys Leu Asp Glu Leu Pro Ile Phe Lys Ser 
                405                 410                 415     


Glu Phe Ile Thr His Asp Ser His Asp Ser Ile Lys Glu Leu Asp Ser 
            420                 425                 430         


Leu Ser Lys Val Lys Asn Asp Gln Leu Arg Ser Phe Cys Pro Ile Glu 
        435                 440                 445             


Leu Asn Ile Asn Gly Ser Pro Gly Ala Glu Ser Asp Leu Ala Thr Phe 
    450                 455                 460                 


Cys Thr Ser Lys Thr Asp Ala Val Leu Met Thr Ser Asp Asp Ser Val 
465                 470                 475                 480 


Thr Gly Ser Glu Leu Ser Pro Leu Val Lys Ala Cys Met Leu Ser Ser 
                485                 490                 495     


Asn Gly Phe Gln Asn Ile Ser Arg Cys Lys Glu Lys Asp Leu Asp Asp 
            500                 505                 510         


Thr Cys Met Leu His Lys Lys Ser Glu Ser Pro Phe Arg Glu Thr Glu 
        515                 520                 525             


Pro Leu Val Ser Pro His Gln Asp Lys Leu Met Ser Met Pro Val Met 
    530                 535                 540                 


Thr Val Asp Tyr Ser Lys Thr Val Val Lys Glu Pro Val Asp Thr Arg 
545                 550                 555                 560 


Val Ser Cys Cys Lys Thr Lys Asp Ser Asp Ile Tyr Cys Thr Leu Asn 
                565                 570                 575     


Asp Ser Asn Pro Ser Leu Cys Asn Ser Glu Ala Glu Asn Ile Glu Pro 
            580                 585                 590         


Ser Val Met Lys Ile Ser Ser Asn Ser Phe Met Asn Val His Leu Glu 
        595                 600                 605             


Ser Lys Pro Val Ile Cys Asp Ser Arg Asn Leu Thr Asp His Ser Lys 
    610                 615                 620                 


Phe Ala Cys Glu Glu Tyr Lys Gln Ser Ile Gly Ser Thr Ser Ser Ala 
625                 630                 635                 640 


Ser Val Asn His Phe Asp Asp Leu Tyr Gln Pro Ile Gly Ser Ser Gly 
                645                 650                 655     


Ile Ala Ser Ser Leu Gln Ser Leu Pro Pro Gly Ile Lys Val Asp Ser 
            660                 665                 670         


Leu Thr Leu Leu Lys Cys Gly Glu Asn Thr Ser Pro Val Leu Asp Ala 
        675                 680                 685             


Val Leu Lys Ser Lys Lys Ser Ser Glu Phe Leu Lys His Ala Gly Lys 
    690                 695                 700                 


Glu Thr Ile Val Glu Val Gly Ser Asp Leu Pro Asp Ser Gly Lys Gly 
705                 710                 715                 720 


Phe Ala Ser Arg Glu Asn Arg Arg Asn Asn Gly Leu Ser Gly Lys Cys 
                725                 730                 735     


Leu Gln Glu Ala Gln Glu Glu Gly Asn Ser Ile Leu Pro Glu Arg Arg 
            740                 745                 750         


Gly Arg Pro Glu Ile Ser Leu Asp Glu Arg Gly Glu Gly Gly His Val 
        755                 760                 765             


His Thr Ser Asp Asp Ser Glu Val Val Phe Ser Ser Cys Asp Leu Asn 
    770                 775                 780                 


Leu Thr Met Glu Asp Ser Asp Gly Val Thr Tyr Ala Leu Lys Cys Asp 
785                 790                 795                 800 


Ser Ser Gly His Ala Pro Glu Ile Val Ser Thr Val His Glu Asp Tyr 
                805                 810                 815     


Ser Gly Ser Ser Glu Ser Ser Asn Asp Glu Ser Asp Ser Glu Asp Thr 
            820                 825                 830         


Asp Ser Asp Asp Ser Ser Ile Pro Arg Asn Arg Leu Gln Ser Val Val 
        835                 840                 845             


Val Val Pro Lys Asn Ser Thr Leu Pro Met Glu Glu Thr Ser Pro Cys 
    850                 855                 860                 


Ser Ser Arg Ser Ser Gln Ser Tyr Arg His Tyr Ser Asp His Trp Glu 
865                 870                 875                 880 


Asp Glu Arg Leu Glu Ser Arg Arg His Leu Tyr Glu Glu Lys Phe Glu 
                885                 890                 895     


Ser Ile Ala Ser Lys Ala Cys Pro Gln Thr Asp Lys Phe Phe Leu His 
            900                 905                 910         


Lys Gly Thr Glu Lys Asn Pro Glu Ile Ser Phe Thr Gln Ser Ser Arg 
        915                 920                 925             


Lys Gln Ile Asp Asn Arg Leu Pro Glu Leu Ser His Pro Gln Ser Asp 
    930                 935                 940                 


Gly Val Asp Ser Thr Ser His Thr Asp Val Lys Ser Asp Pro Leu Gly 
945                 950                 955                 960 


His Pro Asn Ser Glu Glu Thr Val Lys Ala Lys Ile Pro Ser Arg Gln 
                965                 970                 975     


Gln Glu Glu Leu Pro Ile Tyr Ser Ser Asp Phe Glu Asp Val Pro Asn 
            980                 985                 990         


Lys Ser Trp Gln Gln Thr Thr Phe  Gln Asn Arg Pro Asp  Ser Arg Leu 
        995                 1000                 1005             


Gly Lys  Thr Glu Leu Ser Phe  Ser Ser Ser Cys Glu  Ile Pro His 
    1010                 1015                 1020             


Val Asp  Gly Leu His Ser Ser  Glu Glu Leu Arg Asn  Leu Gly Trp 
    1025                 1030                 1035             


Asp Phe  Ser Gln Glu Lys Pro  Ser Thr Thr Tyr Gln  Gln Pro Asp 
    1040                 1045                 1050             


Ser Ser  Tyr Gly Ala Cys Gly  Gly His Lys Tyr Gln  Gln Asn Ala 
    1055                 1060                 1065             


Glu Gln  Tyr Gly Gly Thr Arg  Asp Tyr Trp Gln Gly  Asn Gly Tyr 
    1070                 1075                 1080             


Trp Asp  Pro Arg Ser Gly Arg  Pro Pro Gly Thr Gly  Val Val Tyr 
    1085                 1090                 1095             


Asp Arg  Thr Gln Gly Gln Val  Pro Asp Ser Leu Thr  Asp Asp Arg 
    1100                 1105                 1110             


Glu Glu  Glu Glu Asn Trp Asp  Gln Gln Asp Gly Ser  His Phe Ser 
    1115                 1120                 1125             


Asp Gln  Ser Asp Lys Phe Leu  Leu Ser Leu Gln Lys  Asp Lys Gly 
    1130                 1135                 1140             


Ser Val  Gln Ala Pro Glu Ile  Ser Ser Asn Ser Ile  Lys Asp Thr 
    1145                 1150                 1155             


Leu Ala  Val Asn Glu Lys Lys  Asp Phe Ser Lys Asn  Leu Glu Lys 
    1160                 1165                 1170             


Asn Asp  Ile Lys Asp Arg Gly  Pro Leu Lys Lys Arg  Arg Gln Glu 
    1175                 1180                 1185             


Ile Glu  Ser Asp Ser Glu Ser  Asp Gly Glu Leu Gln  Asp Arg Lys 
    1190                 1195                 1200             


Lys Val  Arg Val Glu Val Glu  Gln Gly Glu Thr Ser  Val Pro Pro 
    1205                 1210                 1215             


Gly Ser  Ala Leu Val Gly Pro  Ser Cys Val Met Asp  Asp Phe Arg 
    1220                 1225                 1230             


Asp Pro  Gln Arg Trp Lys Glu  Cys Ala Lys Gln Gly  Lys Met Pro 
    1235                 1240                 1245             


Cys Tyr  Phe Asp Leu Ile Glu  Glu Asn Val Tyr Leu  Thr Glu Arg 
    1250                 1255                 1260             


Lys Lys  Asn Lys Ser His Arg  Asp Ile Lys Arg Met  Gln Cys Glu 
    1265                 1270                 1275             


Cys Thr  Pro Leu Ser Lys Asp  Glu Arg Ala Gln Gly  Glu Ile Ala 
    1280                 1285                 1290             


Cys Gly  Glu Asp Cys Leu Asn  Arg Leu Leu Met Ile  Glu Cys Ser 
    1295                 1300                 1305             


Ser Arg  Cys Pro Asn Gly Asp  Tyr Cys Ser Asn Arg  Arg Phe Gln 
    1310                 1315                 1320             


Arg Lys  Gln His Ala Asp Val  Glu Val Ile Leu Thr  Glu Lys Lys 
    1325                 1330                 1335             


Gly Trp  Gly Leu Arg Ala Ala  Lys Asp Leu Pro Ser  Asn Thr Phe 
    1340                 1345                 1350             


Val Leu  Glu Tyr Cys Gly Glu  Val Leu Asp His Lys  Glu Phe Lys 
    1355                 1360                 1365             


Ala Arg  Val Lys Glu Tyr Ala  Arg Asn Lys Asn Ile  His Tyr Tyr 
    1370                 1375                 1380             


Phe Met  Ala Leu Lys Asn Asp  Glu Ile Ile Asp Ala  Thr Gln Lys 
    1385                 1390                 1395             


Gly Asn  Cys Ser Arg Phe Met  Asn His Ser Cys Glu  Pro Asn Cys 
    1400                 1405                 1410             


Glu Thr  Gln Lys Trp Thr Val  Asn Gly Gln Leu Arg  Val Gly Phe 
    1415                 1420                 1425             


Phe Thr  Thr Lys Leu Val Pro  Ser Gly Ser Glu Leu  Thr Phe Asp 
    1430                 1435                 1440             


Tyr Gln  Phe Gln Arg Tyr Gly  Lys Glu Ala Gln Lys  Cys Phe Cys 
    1445                 1450                 1455             


Gly Ser  Ala Asn Cys Arg Gly  Tyr Leu Gly Gly Glu  Asn Arg Val 
    1460                 1465                 1470             


Ser Ile  Arg Ala Ala Gly Gly  Lys Met Lys Lys Glu  Arg Ser Arg 
    1475                 1480                 1485             


Lys Lys  Asp Ser Val Asp Gly  Glu Leu Glu Ala Leu  Met Glu Asn 
    1490                 1495                 1500             


Gly Glu  Gly Leu Ser Asp Lys  Asn Gln Val Leu Ser  Leu Ser Arg 
    1505                 1510                 1515             


Leu Met  Val Arg Ile Glu Thr  Leu Glu Gln Lys Leu  Thr Cys Leu 
    1520                 1525                 1530             


Glu Leu  Ile Gln Asn Thr His  Ser Gln Ser Cys Leu  Lys Ser Phe 
    1535                 1540                 1545             


Leu Glu  Arg His Gly Leu Ser  Leu Leu Trp Ile Trp  Met Ala Glu 
    1550                 1555                 1560             


Leu Gly  Asp Gly Arg Glu Ser  Asn Gln Lys Leu Gln  Glu Glu Ile 
    1565                 1570                 1575             


Ile Lys  Thr Leu Glu His Leu  Pro Ile Pro Thr Lys  Asn Met Leu 
    1580                 1585                 1590             


Glu Glu  Ser Lys Val Leu Pro  Ile Ile Gln Arg Trp  Ser Gln Thr 
    1595                 1600                 1605             


Lys Thr  Ala Val Pro Pro Leu  Ser Glu Gly Asp Gly  Tyr Ser Ser 
    1610                 1615                 1620             


Glu Asn  Thr Ser Arg Ala His  Thr Pro Leu Asn Thr  Pro Asp Pro 
    1625                 1630                 1635             


Ser Thr  Lys Leu Ser Thr Glu  Ala Asp Thr Asp Thr  Pro Lys Lys 
    1640                 1645                 1650             


Leu Met  Phe Arg Arg Leu Lys  Ile Ile Ser Glu Asn  Ser Met Asp 
    1655                 1660                 1665             


Ser Ala  Ile Ser Asp Ala Thr  Ser Glu Leu Glu Gly  Lys Asp Gly 
    1670                 1675                 1680             


Lys Glu  Asp Leu Asp Gln Leu  Glu Asn Val Pro Val  Glu Glu Glu 
    1685                 1690                 1695             


Glu Glu  Leu Gln Ser Gln Gln  Leu Leu Pro Gln Gln  Leu Pro Glu 
    1700                 1705                 1710             


Cys Lys  Val Asp Ser Glu Thr  Asn Ile Glu Ala Ser  Lys Leu Pro 
    1715                 1720                 1725             


Thr Ser  Glu Pro Glu Ala Asp  Ala Glu Ile Glu Pro  Lys Glu Ser 
    1730                 1735                 1740             


Asn Gly  Thr Lys Leu Glu Glu  Pro Ile Asn Glu Glu  Thr Pro Ser 
    1745                 1750                 1755             


Gln Asp  Glu Glu Glu Gly Val  Ser Asp Val Glu Ser  Glu Arg Ser 
    1760                 1765                 1770             


Gln Glu  Gln Pro Asp Lys Thr  Val Asp Ile Ser Asp  Leu Ala Thr 
    1775                 1780                 1785             


Lys Leu  Leu Asp Ser Trp Lys  Asp Leu Lys Glu Val  Tyr Arg Ile 
    1790                 1795                 1800             


Pro Lys  Lys Ser Gln Thr Glu  Lys Glu Asn Thr Arg  Asn Gln Pro 
    1805                 1810                 1815             


Glu 
    


<210>  9311
<211>  7780
<212>  DNA
<213>  Homosapiens

<400>  9311
caacactctc atcaccagca ccagtaacag agccagtggc cttgccacat acaccaataa     60

cagttctaat ggcagcacca gtacccttac cagtagatgt agcagttaga tctctgaaag    120

aaccaccaat tataattgta ccagaatctt tagaagcaga tactaagcag gacactatat    180

ctaatagttt agaagaacac gtaactcaaa tattgaatga gcaagcagat atttcctcaa    240

aaaaagaaga ttcccatatt gggaaggatg aagaaattcc agatagttct aagattagtc    300

tgagctgtaa aaaaacaggt tctaagaaga aatcctcaca atctgaaggc atctttcttg    360

gttcagaatc tgatgaagat tctgtacgga cttcttcaag tcaaagatca catgatttaa    420

aattttcagc aagcattgaa aaggaaagag attttaaaaa gagctcagca cctttaaaaa    480

gtgaggatct agggaaacct tcacgatcta aaacagacag agatgataaa tattttagct    540

attcaaaact tgaaagagat actcggtatg tatcttcccg atgtagatca gaaagagagc    600

gacggcggag cagatctcac tctaggtctg agagaggctc tagaactaat ttatcctatt    660

ccaggtcaga acgatctcat tattatgact ctgatcgtcg ctaccatagg agctcccctt    720

atcgagagag gacgcgctat tctcggccat acacagataa cagagcacga gagagttctg    780

actcagaaga agagtataag aagacatact caaggcgtac ctcatctcat tcctcttctt    840

acagagacct aaggacatca tcctattcta aatctgatcg ggactgtaaa actgagacct    900

cttacttaga gatggaaaga agaggcaagt attcttcaaa actagaaaga gaatctaaaa    960

ggacttcaga aaatgaagca attaaaagat gttgttctcc ccctaatgaa ctgggattcc   1020

gacgagggtc atcatattct aagcatgaca gtagtgcttc ccgttataaa tctacccttt   1080

caaaacctat acccaagtct gataaattta aaaattcttt ctgttgtaca gaattaaatg   1140

aagaaatcaa acagtctcat tcttttagtt tacagacacc ttgttcaaaa ggtagtgaat   1200

taagaatgat taataaaaat cctgaaagag aaaaggctgg gtctccagct ccatcaaatc   1260

gattaaatga ttcacctact ttaaaaaagc tagatgaatt gcctattttt aagtccgaat   1320

ttataacaca tgatagccat gatagtatta aggaattaga ctctttatct aaagtgaaga   1380

atgatcaatt aagaagtttt tgtcccatag aattaaatat aaatggatct cctggggcag   1440

aatctgattt ggcaacattt tgcacttcta aaactgatgc tgttttaatg acttctgatg   1500

atagtgtgac tggatcggaa ttatcccctt tggtcaaagc atgcatgctt tcatcaaatg   1560

gatttcagaa tattagtagg tgcaaagaaa aagacttgga tgatacctgc atgctgcata   1620

agaagtcaga aagcccattt agagaaacag aacctctggt gtcaccacac caagataaac   1680

tcatgtctat gccagttatg actgtggatt attccaaaac agtagttaaa gaaccagttg   1740

atacgagggt ttcttgctgc aaaaccaaag attcagacat atactgtact ttgaacgata   1800

gcaacccttc tttgtgtaac tctgaagctg aaaatattga gccttcagtt atgaagattt   1860

cttcaaatag ctttatgaat gtgcatttgg aatcaaaacc agttatatgt gatagtagaa   1920

atttgacaga tcactcaaaa tttgcatgtg aagaatataa gcagagcatc ggtagcacta   1980

gttcagcttc tgttaatcat tttgatgatt tatatcaacc tattgggagt tcaggtattg   2040

cttcatctct tcagagtctt ccaccaggaa taaaggtgga cagtctaact ctcttgaaat   2100

gcggagagaa cacatctcca gttctggatg cagtgctaaa gagtaaaaaa agttcagagt   2160

ttttaaagca tgcagggaaa gaaacaatag tagaagtagg tagtgacctt cctgattcag   2220

gaaagggatt tgcttccagg gagaacaggc gtaataatgg gttatctggg aaatgtttgc   2280

aagaggctca agaagaaggg aattccatat tgcctgaaag aagaggaaga ccagaaatct   2340

ctttagatga aagaggagaa ggaggacatg tgcatacttc tgatgactca gaagttgtat   2400

tttcttcttg tgatttgaat ttaaccatgg aagacagtga tggtgtaact tatgcattaa   2460

agtgtgacag tagtggtcat gccccagaaa ttgtgtctac agttcatgaa gattattctg   2520

gctcttctga aagttcaaat gatgaaagtg attcagaaga tacagattcg gatgatagca   2580

gtattccaag aaaccgtctc cagtctgttg tggttgtgcc aaagaattct actttgccca   2640

tggaagaaac aagtccttgt tcttctcgga gcagtcaaag ttatagacac tattctgacc   2700

attgggaaga tgagagattg gagtcaagga gacatttgta tgaggaaaaa tttgaaagta   2760

tagcaagtaa agcctgtcct caaactgata agtttttcct tcataaagga acagagaaga   2820

atccggaaat ttcttttaca cagtccagta gaaaacaaat agataatcgc ctgcctgaac   2880

tttctcatcc tcagagtgat ggggttgata gtacaagtca tacagatgtg aaatctgacc   2940

ctctgggtca cccaaattca gaggaaaccg tgaaagccaa aataccttct aggcagcaag   3000

aagagctgcc aatttattct tctgattttg aagatgtccc aaataagtct tggcaacaga   3060

ccactttcca aaacaggcca gatagtagac tgggaaaaac agaattgagt ttttcttcct   3120

cttgtgagat accacatgtg gatggcttgc actcatcaga agagctcaga aacttaggtt   3180

gggacttctc tcaagaaaag ccttctacca cgtatcagca acctgacagt agctatggag   3240

cttgtggtgg acacaagtat cagcaaaatg cagaacagta tggtgggaca cgtgattact   3300

ggcaaggcaa tggttactgg gatccaagat caggtagacc tcctggaact ggggttgtgt   3360

atgatcgaac tcaaggacaa gtaccagatt ccctaacaga tgatcgtgaa gaagaggaga   3420

attgggatca acaggatgga tcccattttt cagaccagtc cgataaattt cttctatccc   3480

ttcagaaaga caaggggtca gtgcaagcac ctgaaataag cagcaattcc attaaggaca   3540

ctttagctgt gaatgaaaag aaagattttt caaaaaactt agaaaaaaat gatatcaaag   3600

atagagggcc tcttaaaaaa aggaggcagg aaatagagag tgattctgaa agtgatggtg   3660

agcttcagga cagaaagaaa gttagagtgg aggtagagca gggagagaca tcagtgcccc   3720

caggttcagc actggttggg ccctcctgtg tcatggatga cttcagggac ccacagcgat   3780

ggaaggaatg tgccaagcaa gggaaaatgc catgttactt tgatcttatt gaagaaaatg   3840

tttatttaac agaaagaaag aagaataaat ctcatcgaga tattaagcga atgcagtgtg   3900

agtgtacacc tctttctaaa gatgaaagag ctcaaggtga aatagcatgt ggggaagatt   3960

gtcttaatcg tcttctcatg attgaatgtt cttctcggtg tccaaatggg gattattgtt   4020

ccaatagacg gtttcagaga aaacagcatg cagatgtgga agtcatactc acagaaaaga   4080

aaggctgggg cttgagagct gccaaagacc ttccttcgaa cacctttgtc ctagaatatt   4140

gtggagaggt actcgatcat aaagagttta aagctcgagt gaaggagtat gcacgaaaca   4200

aaaacatcca ttactatttc atggccctga agaatgatga gataatagat gccactcaaa   4260

aaggaaattg ctctcgtttc atgaatcaca gctgtgaacc aaattgtgaa acccaaaaat   4320

ggactgtgaa cggacaactg agggttgggt tttttaccac caaactggtt ccttcaggct   4380

cagagttaac gtttgactat cagttccaga gatatggaaa agaagcccag aaatgtttct   4440

gcggatcagc caattgccgg ggttacctgg gaggagaaaa cagagtcagc atcagagcag   4500

caggagggaa aatgaagaag gaacgatctc gtaagaagga ttcagtggat ggagagctag   4560

aagctctgat ggaaaatggt gagggtctct ctgataaaaa ccaggtgctc agcttatccc   4620

ggctaatggt tagaattgaa actttggagc agaaacttac ctgtctggaa ctcatacaga   4680

acacacactc acagtcctgc ctgaagtcct ttctggaacg tcatgggctg tctttgttgt   4740

ggatctggat ggcagagcta ggtgacggcc gggaaagtaa ccagaagctt caggaagaga   4800

ttataaagac tttggaacac ttgcccattc ctactaaaaa tatgttggag gaaagcaaag   4860

tacttccaat tattcaacgc tggtctcaga ctaagactgc tgtccctccg ttgagtgaag   4920

gagatgggta ttctagtgag aatacatcgc gtgctcatac accactcaac acacctgatc   4980

cttccaccaa gctgagcaca gaagctgaca cagacactcc caagaaacta atgtttcgca   5040

gactgaaaat tataagtgaa aatagcatgg acagtgcaat ctctgatgca accagtgagc   5100

tagaaggcaa ggatggcaaa gaggatcttg atcaattaga aaatgtccct gtagaggaag   5160

aggaagaatt gcagtcacaa cagctactcc cacaacagct gcctgaatgc aaagttgata   5220

gtgaaaccaa catagaagct agtaagctac ctacatctga accagaagct gacgctgaaa   5280

tagagcccaa agagagcaac ggcacaaaac tagaagaacc tattaatgaa gaaacaccat   5340

cccaagatga agaggagggt gtgtctgatg tggagagtga aaggagccaa gaacagccag   5400

ataaaacagt ggatataagt gatttggcca ccaaactcct ggacagttgg aaagacctaa   5460

aggaggtata tcgaattcca aagaaaagtc aaactgaaaa ggaaaacaca acaactgaac   5520

gaggaaggga tgctgttggc ttcagagatc aaacacctgc cccgaagact cctaataggt   5580

caagagagag agacccagac aagcaaactc aaaataaaga gaaaaggaaa cgaagaagct   5640

ccctctcacc accctcttct gcctatgagc ggggaacaaa aaggccagat gacagatatg   5700

atacaccaac ttctaaaaag aaagtacgaa ttaaagaccg caataaactt tctacagagg   5760

aacgccggaa gttgtttgag caagaggtgg ctcaacggga ggctcagaaa caacagcaac   5820

agatgcagaa cctgggaatg acatcaccac tgccctatga ctctcttggt tataatgccc   5880

cgcatcatcc ctttgctggt tacccaccag gttatcccat gcaggcctat gtggatccca   5940

gcaaccctaa tgctggaaag gtgctcctgc ccacacccag catggaccca gtgtgttctc   6000

ctgctcctta tgatcatgct cagcccttgg tgggacattc tacagaaccc ctttctgccc   6060

ctccaccagt accagtggtg ccacatgtgg cagctcctgt ggaagtttcc agttcccagt   6120

atgtggccca gagtgatggt gtagtacacc aagactccag cgttgctgtc ttgccagtgc   6180

cggcccccgg cccagttcag ggacagaatt atagtgtttg ggattcaaac caacagtctg   6240

tcagtgtaca gcagcagtac tctcctgcac agtctcaagc aaccatatat tatcaaggac   6300

agacatgtcc aacagtctat ggtgtgacat caccttattc acagacaact ccaccaattg   6360

tacagagtta tgcccagcca agtcttcagt atatccaggg gcaacagatt ttcacagctc   6420

atccacaagg agtggtggta cagccagccg cagcagtgac tacaatagtt gcaccagggc   6480

agcctcagcc cttgcagcca tctgaaatgg ttgtgacaaa taatctcttg gatctgccgc   6540

ccccctctcc tcccaaacca aaaaccattg tcttacctcc caactggaag acagctcgag   6600

atccagaagg gaagatttat tactaccatg tgatcacaag gcagactcag tgggatcctc   6660

ctacttggga aagcccagga gatgatgcca gccttgagca tgaagctgag atggacctgg   6720

gaactccaac atatgatgaa aaccccatga aggcctcgaa aaagcccaag acagcagaag   6780

cagacacctc cagtgaacta gcaaagaaaa gcaaagaagt attcagaaaa gagatgtccc   6840

agttcatcgt ccagtgcctg aacccttacc ggaaacctga ctgcaaagtg ggaagaatta   6900

ccacaactga agactttaaa catctggctc gcaagctgac tcacggtgtt atgaataagg   6960

agctgaagta ctgtaagaat cctgaggacc tggagtgcaa tgagaatgtg aaacacaaaa   7020

ccaaggagta cattaagaag tacatgcaga agtttggggc tgtttacaaa cccaaagagg   7080

acactgaatt agagtgactg ttgggccagg gtgggaggat gggtggtcag gtaagacaga   7140

ctctagggag aggaaatcct gtgggccttt ctgtcccacc cctgtcagca ctgtgctact   7200

gatgatacat caccctgggg aattcaaccc tgcagatgtc aactgaaggc cacaaaaatg   7260

aactccatct acaagtgatt acctagttgt gagctgttgg catgtggtta gaagccatca   7320

gaggtgcaag ggcttagaaa agaccctggc cagacctgac tccactctta aacctgggtc   7380

ttctccttgg cggtgctgtc agcgcacaga cccatgcgca tccccaccca caacccttta   7440

ccctgatgat ctgtattata ttttaatgta tatgtgaata tattgaaaat aatttgtttt   7500

ttcctggttt ttgtttggtt ttcgttttgc ttttagcctc tacatgctag gatcacagga   7560

agactttgta aggacagttt aagttctcct gcaaggttta atttgttatc atgtaaatat   7620

tctaaagcag gctgccttgt ggttttggcc agccttgtgc tatgttgata agattgattt   7680

actgcttaaa atcactttac tttatccaat ttttactgaa ctttttatgt aaaaaaataa   7740

aatcaattaa agaacttggc atgtgtgttc cctaaaagtt                         7780


<210>  9312
<211>  2342
<212>  PRT
<213>  Homosapiens

<400>  9312

Met Ala Ala Pro Val Pro Leu Pro Val Asp Val Ala Val Arg Ser Leu 
1               5                   10                  15      


Lys Glu Pro Pro Ile Ile Ile Val Pro Glu Ser Leu Glu Ala Asp Thr 
            20                  25                  30          


Lys Gln Asp Thr Ile Ser Asn Ser Leu Glu Glu His Val Thr Gln Ile 
        35                  40                  45              


Leu Asn Glu Gln Ala Asp Ile Ser Ser Lys Lys Glu Asp Ser His Ile 
    50                  55                  60                  


Gly Lys Asp Glu Glu Ile Pro Asp Ser Ser Lys Ile Ser Leu Ser Cys 
65                  70                  75                  80  


Lys Lys Thr Gly Ser Lys Lys Lys Ser Ser Gln Ser Glu Gly Ile Phe 
                85                  90                  95      


Leu Gly Ser Glu Ser Asp Glu Asp Ser Val Arg Thr Ser Ser Ser Gln 
            100                 105                 110         


Arg Ser His Asp Leu Lys Phe Ser Ala Ser Ile Glu Lys Glu Arg Asp 
        115                 120                 125             


Phe Lys Lys Ser Ser Ala Pro Leu Lys Ser Glu Asp Leu Gly Lys Pro 
    130                 135                 140                 


Ser Arg Ser Lys Thr Asp Arg Asp Asp Lys Tyr Phe Ser Tyr Ser Lys 
145                 150                 155                 160 


Leu Glu Arg Asp Thr Arg Tyr Val Ser Ser Arg Cys Arg Ser Glu Arg 
                165                 170                 175     


Glu Arg Arg Arg Ser Arg Ser His Ser Arg Ser Glu Arg Gly Ser Arg 
            180                 185                 190         


Thr Asn Leu Ser Tyr Ser Arg Ser Glu Arg Ser His Tyr Tyr Asp Ser 
        195                 200                 205             


Asp Arg Arg Tyr His Arg Ser Ser Pro Tyr Arg Glu Arg Thr Arg Tyr 
    210                 215                 220                 


Ser Arg Pro Tyr Thr Asp Asn Arg Ala Arg Glu Ser Ser Asp Ser Glu 
225                 230                 235                 240 


Glu Glu Tyr Lys Lys Thr Tyr Ser Arg Arg Thr Ser Ser His Ser Ser 
                245                 250                 255     


Ser Tyr Arg Asp Leu Arg Thr Ser Ser Tyr Ser Lys Ser Asp Arg Asp 
            260                 265                 270         


Cys Lys Thr Glu Thr Ser Tyr Leu Glu Met Glu Arg Arg Gly Lys Tyr 
        275                 280                 285             


Ser Ser Lys Leu Glu Arg Glu Ser Lys Arg Thr Ser Glu Asn Glu Ala 
    290                 295                 300                 


Ile Lys Arg Cys Cys Ser Pro Pro Asn Glu Leu Gly Phe Arg Arg Gly 
305                 310                 315                 320 


Ser Ser Tyr Ser Lys His Asp Ser Ser Ala Ser Arg Tyr Lys Ser Thr 
                325                 330                 335     


Leu Ser Lys Pro Ile Pro Lys Ser Asp Lys Phe Lys Asn Ser Phe Cys 
            340                 345                 350         


Cys Thr Glu Leu Asn Glu Glu Ile Lys Gln Ser His Ser Phe Ser Leu 
        355                 360                 365             


Gln Thr Pro Cys Ser Lys Gly Ser Glu Leu Arg Met Ile Asn Lys Asn 
    370                 375                 380                 


Pro Glu Arg Glu Lys Ala Gly Ser Pro Ala Pro Ser Asn Arg Leu Asn 
385                 390                 395                 400 


Asp Ser Pro Thr Leu Lys Lys Leu Asp Glu Leu Pro Ile Phe Lys Ser 
                405                 410                 415     


Glu Phe Ile Thr His Asp Ser His Asp Ser Ile Lys Glu Leu Asp Ser 
            420                 425                 430         


Leu Ser Lys Val Lys Asn Asp Gln Leu Arg Ser Phe Cys Pro Ile Glu 
        435                 440                 445             


Leu Asn Ile Asn Gly Ser Pro Gly Ala Glu Ser Asp Leu Ala Thr Phe 
    450                 455                 460                 


Cys Thr Ser Lys Thr Asp Ala Val Leu Met Thr Ser Asp Asp Ser Val 
465                 470                 475                 480 


Thr Gly Ser Glu Leu Ser Pro Leu Val Lys Ala Cys Met Leu Ser Ser 
                485                 490                 495     


Asn Gly Phe Gln Asn Ile Ser Arg Cys Lys Glu Lys Asp Leu Asp Asp 
            500                 505                 510         


Thr Cys Met Leu His Lys Lys Ser Glu Ser Pro Phe Arg Glu Thr Glu 
        515                 520                 525             


Pro Leu Val Ser Pro His Gln Asp Lys Leu Met Ser Met Pro Val Met 
    530                 535                 540                 


Thr Val Asp Tyr Ser Lys Thr Val Val Lys Glu Pro Val Asp Thr Arg 
545                 550                 555                 560 


Val Ser Cys Cys Lys Thr Lys Asp Ser Asp Ile Tyr Cys Thr Leu Asn 
                565                 570                 575     


Asp Ser Asn Pro Ser Leu Cys Asn Ser Glu Ala Glu Asn Ile Glu Pro 
            580                 585                 590         


Ser Val Met Lys Ile Ser Ser Asn Ser Phe Met Asn Val His Leu Glu 
        595                 600                 605             


Ser Lys Pro Val Ile Cys Asp Ser Arg Asn Leu Thr Asp His Ser Lys 
    610                 615                 620                 


Phe Ala Cys Glu Glu Tyr Lys Gln Ser Ile Gly Ser Thr Ser Ser Ala 
625                 630                 635                 640 


Ser Val Asn His Phe Asp Asp Leu Tyr Gln Pro Ile Gly Ser Ser Gly 
                645                 650                 655     


Ile Ala Ser Ser Leu Gln Ser Leu Pro Pro Gly Ile Lys Val Asp Ser 
            660                 665                 670         


Leu Thr Leu Leu Lys Cys Gly Glu Asn Thr Ser Pro Val Leu Asp Ala 
        675                 680                 685             


Val Leu Lys Ser Lys Lys Ser Ser Glu Phe Leu Lys His Ala Gly Lys 
    690                 695                 700                 


Glu Thr Ile Val Glu Val Gly Ser Asp Leu Pro Asp Ser Gly Lys Gly 
705                 710                 715                 720 


Phe Ala Ser Arg Glu Asn Arg Arg Asn Asn Gly Leu Ser Gly Lys Cys 
                725                 730                 735     


Leu Gln Glu Ala Gln Glu Glu Gly Asn Ser Ile Leu Pro Glu Arg Arg 
            740                 745                 750         


Gly Arg Pro Glu Ile Ser Leu Asp Glu Arg Gly Glu Gly Gly His Val 
        755                 760                 765             


His Thr Ser Asp Asp Ser Glu Val Val Phe Ser Ser Cys Asp Leu Asn 
    770                 775                 780                 


Leu Thr Met Glu Asp Ser Asp Gly Val Thr Tyr Ala Leu Lys Cys Asp 
785                 790                 795                 800 


Ser Ser Gly His Ala Pro Glu Ile Val Ser Thr Val His Glu Asp Tyr 
                805                 810                 815     


Ser Gly Ser Ser Glu Ser Ser Asn Asp Glu Ser Asp Ser Glu Asp Thr 
            820                 825                 830         


Asp Ser Asp Asp Ser Ser Ile Pro Arg Asn Arg Leu Gln Ser Val Val 
        835                 840                 845             


Val Val Pro Lys Asn Ser Thr Leu Pro Met Glu Glu Thr Ser Pro Cys 
    850                 855                 860                 


Ser Ser Arg Ser Ser Gln Ser Tyr Arg His Tyr Ser Asp His Trp Glu 
865                 870                 875                 880 


Asp Glu Arg Leu Glu Ser Arg Arg His Leu Tyr Glu Glu Lys Phe Glu 
                885                 890                 895     


Ser Ile Ala Ser Lys Ala Cys Pro Gln Thr Asp Lys Phe Phe Leu His 
            900                 905                 910         


Lys Gly Thr Glu Lys Asn Pro Glu Ile Ser Phe Thr Gln Ser Ser Arg 
        915                 920                 925             


Lys Gln Ile Asp Asn Arg Leu Pro Glu Leu Ser His Pro Gln Ser Asp 
    930                 935                 940                 


Gly Val Asp Ser Thr Ser His Thr Asp Val Lys Ser Asp Pro Leu Gly 
945                 950                 955                 960 


His Pro Asn Ser Glu Glu Thr Val Lys Ala Lys Ile Pro Ser Arg Gln 
                965                 970                 975     


Gln Glu Glu Leu Pro Ile Tyr Ser Ser Asp Phe Glu Asp Val Pro Asn 
            980                 985                 990         


Lys Ser Trp Gln Gln Thr Thr Phe  Gln Asn Arg Pro Asp  Ser Arg Leu 
        995                 1000                 1005             


Gly Lys  Thr Glu Leu Ser Phe  Ser Ser Ser Cys Glu  Ile Pro His 
    1010                 1015                 1020             


Val Asp  Gly Leu His Ser Ser  Glu Glu Leu Arg Asn  Leu Gly Trp 
    1025                 1030                 1035             


Asp Phe  Ser Gln Glu Lys Pro  Ser Thr Thr Tyr Gln  Gln Pro Asp 
    1040                 1045                 1050             


Ser Ser  Tyr Gly Ala Cys Gly  Gly His Lys Tyr Gln  Gln Asn Ala 
    1055                 1060                 1065             


Glu Gln  Tyr Gly Gly Thr Arg  Asp Tyr Trp Gln Gly  Asn Gly Tyr 
    1070                 1075                 1080             


Trp Asp  Pro Arg Ser Gly Arg  Pro Pro Gly Thr Gly  Val Val Tyr 
    1085                 1090                 1095             


Asp Arg  Thr Gln Gly Gln Val  Pro Asp Ser Leu Thr  Asp Asp Arg 
    1100                 1105                 1110             


Glu Glu  Glu Glu Asn Trp Asp  Gln Gln Asp Gly Ser  His Phe Ser 
    1115                 1120                 1125             


Asp Gln  Ser Asp Lys Phe Leu  Leu Ser Leu Gln Lys  Asp Lys Gly 
    1130                 1135                 1140             


Ser Val  Gln Ala Pro Glu Ile  Ser Ser Asn Ser Ile  Lys Asp Thr 
    1145                 1150                 1155             


Leu Ala  Val Asn Glu Lys Lys  Asp Phe Ser Lys Asn  Leu Glu Lys 
    1160                 1165                 1170             


Asn Asp  Ile Lys Asp Arg Gly  Pro Leu Lys Lys Arg  Arg Gln Glu 
    1175                 1180                 1185             


Ile Glu  Ser Asp Ser Glu Ser  Asp Gly Glu Leu Gln  Asp Arg Lys 
    1190                 1195                 1200             


Lys Val  Arg Val Glu Val Glu  Gln Gly Glu Thr Ser  Val Pro Pro 
    1205                 1210                 1215             


Gly Ser  Ala Leu Val Gly Pro  Ser Cys Val Met Asp  Asp Phe Arg 
    1220                 1225                 1230             


Asp Pro  Gln Arg Trp Lys Glu  Cys Ala Lys Gln Gly  Lys Met Pro 
    1235                 1240                 1245             


Cys Tyr  Phe Asp Leu Ile Glu  Glu Asn Val Tyr Leu  Thr Glu Arg 
    1250                 1255                 1260             


Lys Lys  Asn Lys Ser His Arg  Asp Ile Lys Arg Met  Gln Cys Glu 
    1265                 1270                 1275             


Cys Thr  Pro Leu Ser Lys Asp  Glu Arg Ala Gln Gly  Glu Ile Ala 
    1280                 1285                 1290             


Cys Gly  Glu Asp Cys Leu Asn  Arg Leu Leu Met Ile  Glu Cys Ser 
    1295                 1300                 1305             


Ser Arg  Cys Pro Asn Gly Asp  Tyr Cys Ser Asn Arg  Arg Phe Gln 
    1310                 1315                 1320             


Arg Lys  Gln His Ala Asp Val  Glu Val Ile Leu Thr  Glu Lys Lys 
    1325                 1330                 1335             


Gly Trp  Gly Leu Arg Ala Ala  Lys Asp Leu Pro Ser  Asn Thr Phe 
    1340                 1345                 1350             


Val Leu  Glu Tyr Cys Gly Glu  Val Leu Asp His Lys  Glu Phe Lys 
    1355                 1360                 1365             


Ala Arg  Val Lys Glu Tyr Ala  Arg Asn Lys Asn Ile  His Tyr Tyr 
    1370                 1375                 1380             


Phe Met  Ala Leu Lys Asn Asp  Glu Ile Ile Asp Ala  Thr Gln Lys 
    1385                 1390                 1395             


Gly Asn  Cys Ser Arg Phe Met  Asn His Ser Cys Glu  Pro Asn Cys 
    1400                 1405                 1410             


Glu Thr  Gln Lys Trp Thr Val  Asn Gly Gln Leu Arg  Val Gly Phe 
    1415                 1420                 1425             


Phe Thr  Thr Lys Leu Val Pro  Ser Gly Ser Glu Leu  Thr Phe Asp 
    1430                 1435                 1440             


Tyr Gln  Phe Gln Arg Tyr Gly  Lys Glu Ala Gln Lys  Cys Phe Cys 
    1445                 1450                 1455             


Gly Ser  Ala Asn Cys Arg Gly  Tyr Leu Gly Gly Glu  Asn Arg Val 
    1460                 1465                 1470             


Ser Ile  Arg Ala Ala Gly Gly  Lys Met Lys Lys Glu  Arg Ser Arg 
    1475                 1480                 1485             


Lys Lys  Asp Ser Val Asp Gly  Glu Leu Glu Ala Leu  Met Glu Asn 
    1490                 1495                 1500             


Gly Glu  Gly Leu Ser Asp Lys  Asn Gln Val Leu Ser  Leu Ser Arg 
    1505                 1510                 1515             


Leu Met  Val Arg Ile Glu Thr  Leu Glu Gln Lys Leu  Thr Cys Leu 
    1520                 1525                 1530             


Glu Leu  Ile Gln Asn Thr His  Ser Gln Ser Cys Leu  Lys Ser Phe 
    1535                 1540                 1545             


Leu Glu  Arg His Gly Leu Ser  Leu Leu Trp Ile Trp  Met Ala Glu 
    1550                 1555                 1560             


Leu Gly  Asp Gly Arg Glu Ser  Asn Gln Lys Leu Gln  Glu Glu Ile 
    1565                 1570                 1575             


Ile Lys  Thr Leu Glu His Leu  Pro Ile Pro Thr Lys  Asn Met Leu 
    1580                 1585                 1590             


Glu Glu  Ser Lys Val Leu Pro  Ile Ile Gln Arg Trp  Ser Gln Thr 
    1595                 1600                 1605             


Lys Thr  Ala Val Pro Pro Leu  Ser Glu Gly Asp Gly  Tyr Ser Ser 
    1610                 1615                 1620             


Glu Asn  Thr Ser Arg Ala His  Thr Pro Leu Asn Thr  Pro Asp Pro 
    1625                 1630                 1635             


Ser Thr  Lys Leu Ser Thr Glu  Ala Asp Thr Asp Thr  Pro Lys Lys 
    1640                 1645                 1650             


Leu Met  Phe Arg Arg Leu Lys  Ile Ile Ser Glu Asn  Ser Met Asp 
    1655                 1660                 1665             


Ser Ala  Ile Ser Asp Ala Thr  Ser Glu Leu Glu Gly  Lys Asp Gly 
    1670                 1675                 1680             


Lys Glu  Asp Leu Asp Gln Leu  Glu Asn Val Pro Val  Glu Glu Glu 
    1685                 1690                 1695             


Glu Glu  Leu Gln Ser Gln Gln  Leu Leu Pro Gln Gln  Leu Pro Glu 
    1700                 1705                 1710             


Cys Lys  Val Asp Ser Glu Thr  Asn Ile Glu Ala Ser  Lys Leu Pro 
    1715                 1720                 1725             


Thr Ser  Glu Pro Glu Ala Asp  Ala Glu Ile Glu Pro  Lys Glu Ser 
    1730                 1735                 1740             


Asn Gly  Thr Lys Leu Glu Glu  Pro Ile Asn Glu Glu  Thr Pro Ser 
    1745                 1750                 1755             


Gln Asp  Glu Glu Glu Gly Val  Ser Asp Val Glu Ser  Glu Arg Ser 
    1760                 1765                 1770             


Gln Glu  Gln Pro Asp Lys Thr  Val Asp Ile Ser Asp  Leu Ala Thr 
    1775                 1780                 1785             


Lys Leu  Leu Asp Ser Trp Lys  Asp Leu Lys Glu Val  Tyr Arg Ile 
    1790                 1795                 1800             


Pro Lys  Lys Ser Gln Thr Glu  Lys Glu Asn Thr Thr  Thr Glu Arg 
    1805                 1810                 1815             


Gly Arg  Asp Ala Val Gly Phe  Arg Asp Gln Thr Pro  Ala Pro Lys 
    1820                 1825                 1830             


Thr Pro  Asn Arg Ser Arg Glu  Arg Asp Pro Asp Lys  Gln Thr Gln 
    1835                 1840                 1845             


Asn Lys  Glu Lys Arg Lys Arg  Arg Ser Ser Leu Ser  Pro Pro Ser 
    1850                 1855                 1860             


Ser Ala  Tyr Glu Arg Gly Thr  Lys Arg Pro Asp Asp  Arg Tyr Asp 
    1865                 1870                 1875             


Thr Pro  Thr Ser Lys Lys Lys  Val Arg Ile Lys Asp  Arg Asn Lys 
    1880                 1885                 1890             


Leu Ser  Thr Glu Glu Arg Arg  Lys Leu Phe Glu Gln  Glu Val Ala 
    1895                 1900                 1905             


Gln Arg  Glu Ala Gln Lys Gln  Gln Gln Gln Met Gln  Asn Leu Gly 
    1910                 1915                 1920             


Met Thr  Ser Pro Leu Pro Tyr  Asp Ser Leu Gly Tyr  Asn Ala Pro 
    1925                 1930                 1935             


His His  Pro Phe Ala Gly Tyr  Pro Pro Gly Tyr Pro  Met Gln Ala 
    1940                 1945                 1950             


Tyr Val  Asp Pro Ser Asn Pro  Asn Ala Gly Lys Val  Leu Leu Pro 
    1955                 1960                 1965             


Thr Pro  Ser Met Asp Pro Val  Cys Ser Pro Ala Pro  Tyr Asp His 
    1970                 1975                 1980             


Ala Gln  Pro Leu Val Gly His  Ser Thr Glu Pro Leu  Ser Ala Pro 
    1985                 1990                 1995             


Pro Pro  Val Pro Val Val Pro  His Val Ala Ala Pro  Val Glu Val 
    2000                 2005                 2010             


Ser Ser  Ser Gln Tyr Val Ala  Gln Ser Asp Gly Val  Val His Gln 
    2015                 2020                 2025             


Asp Ser  Ser Val Ala Val Leu  Pro Val Pro Ala Pro  Gly Pro Val 
    2030                 2035                 2040             


Gln Gly  Gln Asn Tyr Ser Val  Trp Asp Ser Asn Gln  Gln Ser Val 
    2045                 2050                 2055             


Ser Val  Gln Gln Gln Tyr Ser  Pro Ala Gln Ser Gln  Ala Thr Ile 
    2060                 2065                 2070             


Tyr Tyr  Gln Gly Gln Thr Cys  Pro Thr Val Tyr Gly  Val Thr Ser 
    2075                 2080                 2085             


Pro Tyr  Ser Gln Thr Thr Pro  Pro Ile Val Gln Ser  Tyr Ala Gln 
    2090                 2095                 2100             


Pro Ser  Leu Gln Tyr Ile Gln  Gly Gln Gln Ile Phe  Thr Ala His 
    2105                 2110                 2115             


Pro Gln  Gly Val Val Val Gln  Pro Ala Ala Ala Val  Thr Thr Ile 
    2120                 2125                 2130             


Val Ala  Pro Gly Gln Pro Gln  Pro Leu Gln Pro Ser  Glu Met Val 
    2135                 2140                 2145             


Val Thr  Asn Asn Leu Leu Asp  Leu Pro Pro Pro Ser  Pro Pro Lys 
    2150                 2155                 2160             


Pro Lys  Thr Ile Val Leu Pro  Pro Asn Trp Lys Thr  Ala Arg Asp 
    2165                 2170                 2175             


Pro Glu  Gly Lys Ile Tyr Tyr  Tyr His Val Ile Thr  Arg Gln Thr 
    2180                 2185                 2190             


Gln Trp  Asp Pro Pro Thr Trp  Glu Ser Pro Gly Asp  Asp Ala Ser 
    2195                 2200                 2205             


Leu Glu  His Glu Ala Glu Met  Asp Leu Gly Thr Pro  Thr Tyr Asp 
    2210                 2215                 2220             


Glu Asn  Pro Met Lys Ala Ser  Lys Lys Pro Lys Thr  Ala Glu Ala 
    2225                 2230                 2235             


Asp Thr  Ser Ser Glu Leu Ala  Lys Lys Ser Lys Glu  Val Phe Arg 
    2240                 2245                 2250             


Lys Glu  Met Ser Gln Phe Ile  Val Gln Cys Leu Asn  Pro Tyr Arg 
    2255                 2260                 2265             


Lys Pro  Asp Cys Lys Val Gly  Arg Ile Thr Thr Thr  Glu Asp Phe 
    2270                 2275                 2280             


Lys His  Leu Ala Arg Lys Leu  Thr His Gly Val Met  Asn Lys Glu 
    2285                 2290                 2295             


Leu Lys  Tyr Cys Lys Asn Pro  Glu Asp Leu Glu Cys  Asn Glu Asn 
    2300                 2305                 2310             


Val Lys  His Lys Thr Lys Glu  Tyr Ile Lys Lys Tyr  Met Gln Lys 
    2315                 2320                 2325             


Phe Gly  Ala Val Tyr Lys Pro  Lys Glu Asp Thr Glu  Leu Glu 
    2330                 2335                 2340         


<210>  9313
<211>  7824
<212>  DNA
<213>  Homosapiens

<400>  9313
caacactctc atcaccagca ccagtaacag agccagtggc cttgccacat acaccaataa     60

cagttctaat ggcagcacca gtacccttac cagtagatgt agcagttaga tctctgaaag    120

aaccaccaat tataattgta ccagaatctt tagaagcaga tactaagcag gacactatat    180

ctaatagttt agaagaacac gtaactcaaa tattgaatga gcaagcagat atttcctcaa    240

aaaaagaaga ttcccatatt gggaaggatg aagaaattcc agatagttct aagattagtc    300

tgagctgtaa aaaaacaggt tctaagaaga aatcctcaca atctgaaggc atctttcttg    360

gttcagaatc tgatgaagat tctgtacgga cttcttcaag tcaaagatca catgatttaa    420

aattttcagc aagcattgaa aaggaaagag attttaaaaa gagctcagca cctttaaaaa    480

gtgaggatct agggaaacct tcacgatcta aaacagacag agatgataaa tattttagct    540

attcaaaact tgaaagagat actcggtatg tatcttcccg atgtagatca gaaagagagc    600

gacggcggag cagatctcac tctaggtctg agagaggctc tagaactaat ttatcctatt    660

ccaggtcaga acgatctcat tattatgact ctgatcgtcg ctaccatagg agctcccctt    720

atcgagagag gacgcgctat tctcggccat acacagataa cagagcacga gagagttctg    780

actcagaaga agagtataag aagacatact caaggcgtac ctcatctcat tcctcttctt    840

acagagacct aaggacatca tcctattcta aatctgatcg ggactgtaaa actgagacct    900

cttacttaga gatggaaaga agaggcaagt attcttcaaa actagaaaga gaatctaaaa    960

ggacttcaga aaatgaagca attaaaagat gttgttctcc ccctaatgaa ctgggattcc   1020

gacgagggtc atcatattct aagcatgaca gtagtgcttc ccgttataaa tctacccttt   1080

caaaacctat acccaagtct gataaattta aaaattcttt ctgttgtaca gaattaaatg   1140

aagaaatcaa acagtctcat tcttttagtt tacagacacc ttgttcaaaa ggtagtgaat   1200

taagaatgat taataaaaat cctgaaagag aaaaggctgg gtctccagct ccatcaaatc   1260

gattaaatga ttcacctact ttaaaaaagc tagatgaatt gcctattttt aagtccgaat   1320

ttataacaca tgatagccat gatagtatta aggaattaga ctctttatct aaagtgaaga   1380

atgatcaatt aagaagtttt tgtcccatag aattaaatat aaatggatct cctggggcag   1440

aatctgattt ggcaacattt tgcacttcta aaactgatgc tgttttaatg acttctgatg   1500

atagtgtgac tggatcggaa ttatcccctt tggtcaaagc atgcatgctt tcatcaaatg   1560

gatttcagaa tattagtagg tgcaaagaaa aagacttgga tgatacctgc atgctgcata   1620

agaagtcaga aagcccattt agagaaacag aacctctggt gtcaccacac caagataaac   1680

tcatgtctat gccagttatg actgtggatt attccaaaac agtagttaaa gaaccagttg   1740

atacgagggt ttcttgctgc aaaaccaaag attcagacat atactgtact ttgaacgata   1800

gcaacccttc tttgtgtaac tctgaagctg aaaatattga gccttcagtt atgaagattt   1860

cttcaaatag ctttatgaat gtgcatttgg aatcaaaacc agttatatgt gatagtagaa   1920

atttgacaga tcactcaaaa tttgcatgtg aagaatataa gcagagcatc ggtagcacta   1980

gttcagcttc tgttaatcat tttgatgatt tatatcaacc tattgggagt tcaggtattg   2040

cttcatctct tcagagtctt ccaccaggaa taaaggtgga cagtctaact ctcttgaaat   2100

gcggagagaa cacatctcca gttctggatg cagtgctaaa gagtaaaaaa agttcagagt   2160

ttttaaagca tgcagggaaa gaaacaatag tagaagtagg tagtgacctt cctgattcag   2220

gaaagggatt tgcttccagg gagaacaggc gtaataatgg gttatctggg aaatgtttgc   2280

aagaggctca agaagaaggg aattccatat tgcctgaaag aagaggaaga ccagaaatct   2340

ctttagatga aagaggagaa ggaggacatg tgcatacttc tgatgactca gaagttgtat   2400

tttcttcttg tgatttgaat ttaaccatgg aagacagtga tggtgtaact tatgcattaa   2460

agtgtgacag tagtggtcat gccccagaaa ttgtgtctac agttcatgaa gattattctg   2520

gctcttctga aagttcaaat gatgaaagtg attcagaaga tacagattcg gatgatagca   2580

gtattccaag aaaccgtctc cagtctgttg tggttgtgcc aaagaattct actttgccca   2640

tggaagaaac aagtccttgt tcttctcgga gcagtcaaag ttatagacac tattctgacc   2700

attgggaaga tgagagattg gagtcaagga gacatttgta tgaggaaaaa tttgaaagta   2760

tagcaagtaa agcctgtcct caaactgata agtttttcct tcataaagga acagagaaga   2820

atccggaaat ttcttttaca cagtccagta gaaaacaaat agataatcgc ctgcctgaac   2880

tttctcatcc tcagagtgat ggggttgata gtacaagtca tacagatgtg aaatctgacc   2940

ctctgggtca cccaaattca gaggaaaccg tgaaagccaa aataccttct aggcagcaag   3000

aagagctgcc aatttattct tctgattttg aagatgtccc aaataagtct tggcaacaga   3060

ccactttcca aaacaggcca gatagtagac tgggaaaaac agaattgagt ttttcttcct   3120

cttgtgagat accacatgtg gatggcttgc actcatcaga agagctcaga aacttaggtt   3180

gggacttctc tcaagaaaag ccttctacca cgtatcagca acctgacagt agctatggag   3240

cttgtggtgg acacaagtat cagcaaaatg cagaacagta tggtgggaca cgtgattact   3300

ggcaaggcaa tggttactgg gatccaagat caggtagacc tcctggaact ggggttgtgt   3360

atgatcgaac tcaaggacaa gtaccagatt ccctaacaga tgatcgtgaa gaagaggaga   3420

attgggatca acaggatgga tcccattttt cagaccagtc cgataaattt cttctatccc   3480

ttcagaaaga caaggggtca gtgcaagcac ctgaaataag cagcaattcc attaaggaca   3540

ctttagctgt gaatgaaaag aaagattttt caaaaaactt agaaaaaaat gatatcaaag   3600

atagagggcc tcttaaaaaa aggaggcagg aaatagagag tgattctgaa agtgatggtg   3660

agcttcagga cagaaagaaa gttagagtgg aggtagagca gggagagaca tcagtgcccc   3720

caggttcagc actggttggg ccctcctgtg tcatggatga cttcagggac ccacagcgat   3780

ggaaggaatg tgccaagcaa gggaaaatgc catgttactt tgatcttatt gaagaaaatg   3840

tttatttaac agaaagaaag aagaataaat ctcatcgaga tattaagcga atgcagtgtg   3900

agtgtacacc tctttctaaa gatgaaagag ctcaaggtga aatagcatgt ggggaagatt   3960

gtcttaatcg tcttctcatg attgaatgtt cttctcggtg tccaaatggg gattattgtt   4020

ccaatagacg gtttcagaga aaacagcatg cagatgtgga agtcatactc acagaaaaga   4080

aaggctgggg cttgagagct gccaaagacc ttccttcata atagatgcca ctcaaaaagg   4140

aaattgctct cgtttcatga atcacagctg tgaaccaaat tgtgaaaccc aaaaatggac   4200

tgtgaacgga caactgaggg ttgggttttt taccaccaaa ctggttcctt caggctcaga   4260

gttaacgttt gactatcagt tccagagata tggaaaagaa gcccagaaat gtttctgcgg   4320

atcagccaat tgccggggtt acctgggagg agaaaacaga gtcagcatca gagcagcagg   4380

agggaaaatg aagaaggaac gatctcgtaa gaaggattca gtggatggag agctagaagc   4440

tctgatggaa aatggtgagg gtctctctga taaaaaccag gtgctcagct tatcccggct   4500

aatggttaga attgaaactt tggagcagaa acttacctgt ctggaactca tacagaacac   4560

acactcacag tcctgcctga agtcctttct ggaacgtcat gggctgtctt tgttgtggat   4620

ctggatggca gagctaggtg acggccggga aagtaaccag aagcttcagg aagagattat   4680

aaagactttg gaacacttgc ccattcctac taaaaatatg ttggaggaaa gcaaagtact   4740

tccaattatt caacgctggt ctcagactaa gactgctgtc cctccgttga gtgaaggaga   4800

tgggtattct agtgagaata catcgcgtgc tcatacacca ctcaacacac ctgatccttc   4860

caccaagctg agcacagaag ctgacacaga cactcccaag aaactaatgt ttcgcagact   4920

gaaaattata agtgaaaata gcatggacag tgcaatctct gatgcaacca gtgagctaga   4980

aggcaaggat ggcaaagagg atcttgatca attagaaaat gtccctgtag aggaagagga   5040

agaattgcag tcacaacagc tactcccaca acagctgcct gaatgcaaag ttgatagtga   5100

aaccaacata gaagctagta agctacctac atctgaacca gaagctgacg ctgaaataga   5160

gcccaaagag agcaacggca caaaactaga agaacctatt aatgaagaaa caccatccca   5220

agatgaagag gagggtgtgt ctgatgtgga gagtgaaagg agccaagaac agccagataa   5280

aacagtggat ataagtgatt tggccaccaa actcctggac agttggaaag acctaaagct   5340

tctcagggca gcaaggagct tgttaacatc accagctgac catgtgtctc cttttctcaa   5400

ctccatttcc aacttcgtgc tgaagaaaaa cgagaaccta gcgtgcattc tgtgaagaaa   5460

caggaagatg gttgggaagt tggatgatgc atgaaaaata taataggagg tatatcgaat   5520

tccaaagaaa agtcaaactg aaaaggaaaa cacaacaact gaacgaggaa gggatgctgt   5580

tggcttcaga gatcaaacac ctgccccgaa gactcctaat aggtcaagag agagagaccc   5640

agacaagcaa actcaaaata aagagaaaag gaaacgaaga agctccctct caccaccctc   5700

ttctgcctat gagcggggaa caaaaaggcc agatgacaga tatgatacac caacttctaa   5760

aaagaaagta cgaattaaag accgcaataa actttctaca gaggaacgcc ggaagttgtt   5820

tgagcaagag gtggctcaac gggaggctca gaaacaacag caacagatgc agaacctggg   5880

aatgacatca ccactgccct atgactctct tggttataat gccccgcatc atccctttgc   5940

tggttaccca ccaggttatc ccatgcaggc ctatgtggat cccagcaacc ctaatgctgg   6000

aaaggtgctc ctgcccacac ccagcatgga cccagtgtgt tctcctgctc cttatgatca   6060

tgctcagccc ttggtgggac attctacaga acccctttct gcccctccac cagtaccagt   6120

ggtgccacat gtggcagctc ctgtggaagt ttccagttcc cagtatgtgg cccagagtga   6180

tggtgtagta caccaagact ccagcgttgc tgtcttgcca gtgccggccc ccggcccagt   6240

tcagggacag aattatagtg tttgggattc aaaccaacag tctgtcagtg tacagcagca   6300

gtactctcct gcacagtctc aagcaaccat atattatcaa ggacagacat gtccaacagt   6360

ctatggtgtg acatcacctt attcacagac aactccacca attgtacaga gttatgccca   6420

gccaagtctt cagtatatcc aggggcaaca gattttcaca gctcatccac aaggagtggt   6480

ggtacagcca gccgcagcag tgactacaat agttgcacca gggcagcctc agcccttgca   6540

gccatctgaa atggttgtga caaataatct cttggatctg ccgcccccct ctcctcccaa   6600

accaaaaacc attgtcttac ctcccaactg gaagacagct cgagatccag aagggaagat   6660

ttattactac catgtgatca caaggcagac tcagtgggat cctcctactt gggaaagccc   6720

aggagatgat gccagccttg agcatgaagc tgagatggac ctgggaactc caacatatga   6780

tgaaaacccc atgaaggcct cgaaaaagcc caagacagca gaagcagaca cctccagtga   6840

actagcaaag aaaagcaaag aagtattcag aaaagagatg tcccagttca tcgtccagtg   6900

cctgaaccct taccggaaac ctgactgcaa agtgggaaga attaccacaa ctgaagactt   6960

taaacatctg gctcgcaagc tgactcacgg tgttatgaat aaggagctga agtactgtaa   7020

gaatcctgag gacctggagt gcaatgagaa tgtgaaacac aaaaccaagg agtacattaa   7080

gaagtacatg cagaagtttg gggctgttta caaacccaaa gaggacactg aattagagtg   7140

actgttgggc cagggtggga ggatgggtgg tcaggtaaga cagactctag ggagaggaaa   7200

tcctgtgggc ctttctgtcc cacccctgtc agcactgtgc tactgatgat acatcaccct   7260

ggggaattca accctgcaga tgtcaactga aggccacaaa aatgaactcc atctacaagt   7320

gattacctag ttgtgagctg ttggcatgtg gttagaagcc atcagaggtg caagggctta   7380

gaaaagaccc tggccagacc tgactccact cttaaacctg ggtcttctcc ttggcggtgc   7440

tgtcagcgca cagacccatg cgcatcccca cccacaaccc tttaccctga tgatctgtat   7500

tatattttaa tgtatatgtg aatatattga aaataatttg ttttttcctg gtttttgttt   7560

ggttttcgtt ttgcttttag cctctacatg ctaggatcac aggaagactt tgtaaggaca   7620

gtttaagttc tcctgcaagg tttaatttgt tatcatgtaa atattctaaa gcaggctgcc   7680

ttgtggtttt ggccagcctt gtgctatgtt gataagattg atttactgct taaaatcact   7740

ttactttatc caatttttac tgaacttttt atgtaaaaaa ataaaatcaa ttaaagaact   7800

tggcatgtgt gttccctaaa agtt                                          7824


<210>  9314
<211>  1350
<212>  PRT
<213>  Homosapiens

<400>  9314

Met Ala Ala Pro Val Pro Leu Pro Val Asp Val Ala Val Arg Ser Leu 
1               5                   10                  15      


Lys Glu Pro Pro Ile Ile Ile Val Pro Glu Ser Leu Glu Ala Asp Thr 
            20                  25                  30          


Lys Gln Asp Thr Ile Ser Asn Ser Leu Glu Glu His Val Thr Gln Ile 
        35                  40                  45              


Leu Asn Glu Gln Ala Asp Ile Ser Ser Lys Lys Glu Asp Ser His Ile 
    50                  55                  60                  


Gly Lys Asp Glu Glu Ile Pro Asp Ser Ser Lys Ile Ser Leu Ser Cys 
65                  70                  75                  80  


Lys Lys Thr Gly Ser Lys Lys Lys Ser Ser Gln Ser Glu Gly Ile Phe 
                85                  90                  95      


Leu Gly Ser Glu Ser Asp Glu Asp Ser Val Arg Thr Ser Ser Ser Gln 
            100                 105                 110         


Arg Ser His Asp Leu Lys Phe Ser Ala Ser Ile Glu Lys Glu Arg Asp 
        115                 120                 125             


Phe Lys Lys Ser Ser Ala Pro Leu Lys Ser Glu Asp Leu Gly Lys Pro 
    130                 135                 140                 


Ser Arg Ser Lys Thr Asp Arg Asp Asp Lys Tyr Phe Ser Tyr Ser Lys 
145                 150                 155                 160 


Leu Glu Arg Asp Thr Arg Tyr Val Ser Ser Arg Cys Arg Ser Glu Arg 
                165                 170                 175     


Glu Arg Arg Arg Ser Arg Ser His Ser Arg Ser Glu Arg Gly Ser Arg 
            180                 185                 190         


Thr Asn Leu Ser Tyr Ser Arg Ser Glu Arg Ser His Tyr Tyr Asp Ser 
        195                 200                 205             


Asp Arg Arg Tyr His Arg Ser Ser Pro Tyr Arg Glu Arg Thr Arg Tyr 
    210                 215                 220                 


Ser Arg Pro Tyr Thr Asp Asn Arg Ala Arg Glu Ser Ser Asp Ser Glu 
225                 230                 235                 240 


Glu Glu Tyr Lys Lys Thr Tyr Ser Arg Arg Thr Ser Ser His Ser Ser 
                245                 250                 255     


Ser Tyr Arg Asp Leu Arg Thr Ser Ser Tyr Ser Lys Ser Asp Arg Asp 
            260                 265                 270         


Cys Lys Thr Glu Thr Ser Tyr Leu Glu Met Glu Arg Arg Gly Lys Tyr 
        275                 280                 285             


Ser Ser Lys Leu Glu Arg Glu Ser Lys Arg Thr Ser Glu Asn Glu Ala 
    290                 295                 300                 


Ile Lys Arg Cys Cys Ser Pro Pro Asn Glu Leu Gly Phe Arg Arg Gly 
305                 310                 315                 320 


Ser Ser Tyr Ser Lys His Asp Ser Ser Ala Ser Arg Tyr Lys Ser Thr 
                325                 330                 335     


Leu Ser Lys Pro Ile Pro Lys Ser Asp Lys Phe Lys Asn Ser Phe Cys 
            340                 345                 350         


Cys Thr Glu Leu Asn Glu Glu Ile Lys Gln Ser His Ser Phe Ser Leu 
        355                 360                 365             


Gln Thr Pro Cys Ser Lys Gly Ser Glu Leu Arg Met Ile Asn Lys Asn 
    370                 375                 380                 


Pro Glu Arg Glu Lys Ala Gly Ser Pro Ala Pro Ser Asn Arg Leu Asn 
385                 390                 395                 400 


Asp Ser Pro Thr Leu Lys Lys Leu Asp Glu Leu Pro Ile Phe Lys Ser 
                405                 410                 415     


Glu Phe Ile Thr His Asp Ser His Asp Ser Ile Lys Glu Leu Asp Ser 
            420                 425                 430         


Leu Ser Lys Val Lys Asn Asp Gln Leu Arg Ser Phe Cys Pro Ile Glu 
        435                 440                 445             


Leu Asn Ile Asn Gly Ser Pro Gly Ala Glu Ser Asp Leu Ala Thr Phe 
    450                 455                 460                 


Cys Thr Ser Lys Thr Asp Ala Val Leu Met Thr Ser Asp Asp Ser Val 
465                 470                 475                 480 


Thr Gly Ser Glu Leu Ser Pro Leu Val Lys Ala Cys Met Leu Ser Ser 
                485                 490                 495     


Asn Gly Phe Gln Asn Ile Ser Arg Cys Lys Glu Lys Asp Leu Asp Asp 
            500                 505                 510         


Thr Cys Met Leu His Lys Lys Ser Glu Ser Pro Phe Arg Glu Thr Glu 
        515                 520                 525             


Pro Leu Val Ser Pro His Gln Asp Lys Leu Met Ser Met Pro Val Met 
    530                 535                 540                 


Thr Val Asp Tyr Ser Lys Thr Val Val Lys Glu Pro Val Asp Thr Arg 
545                 550                 555                 560 


Val Ser Cys Cys Lys Thr Lys Asp Ser Asp Ile Tyr Cys Thr Leu Asn 
                565                 570                 575     


Asp Ser Asn Pro Ser Leu Cys Asn Ser Glu Ala Glu Asn Ile Glu Pro 
            580                 585                 590         


Ser Val Met Lys Ile Ser Ser Asn Ser Phe Met Asn Val His Leu Glu 
        595                 600                 605             


Ser Lys Pro Val Ile Cys Asp Ser Arg Asn Leu Thr Asp His Ser Lys 
    610                 615                 620                 


Phe Ala Cys Glu Glu Tyr Lys Gln Ser Ile Gly Ser Thr Ser Ser Ala 
625                 630                 635                 640 


Ser Val Asn His Phe Asp Asp Leu Tyr Gln Pro Ile Gly Ser Ser Gly 
                645                 650                 655     


Ile Ala Ser Ser Leu Gln Ser Leu Pro Pro Gly Ile Lys Val Asp Ser 
            660                 665                 670         


Leu Thr Leu Leu Lys Cys Gly Glu Asn Thr Ser Pro Val Leu Asp Ala 
        675                 680                 685             


Val Leu Lys Ser Lys Lys Ser Ser Glu Phe Leu Lys His Ala Gly Lys 
    690                 695                 700                 


Glu Thr Ile Val Glu Val Gly Ser Asp Leu Pro Asp Ser Gly Lys Gly 
705                 710                 715                 720 


Phe Ala Ser Arg Glu Asn Arg Arg Asn Asn Gly Leu Ser Gly Lys Cys 
                725                 730                 735     


Leu Gln Glu Ala Gln Glu Glu Gly Asn Ser Ile Leu Pro Glu Arg Arg 
            740                 745                 750         


Gly Arg Pro Glu Ile Ser Leu Asp Glu Arg Gly Glu Gly Gly His Val 
        755                 760                 765             


His Thr Ser Asp Asp Ser Glu Val Val Phe Ser Ser Cys Asp Leu Asn 
    770                 775                 780                 


Leu Thr Met Glu Asp Ser Asp Gly Val Thr Tyr Ala Leu Lys Cys Asp 
785                 790                 795                 800 


Ser Ser Gly His Ala Pro Glu Ile Val Ser Thr Val His Glu Asp Tyr 
                805                 810                 815     


Ser Gly Ser Ser Glu Ser Ser Asn Asp Glu Ser Asp Ser Glu Asp Thr 
            820                 825                 830         


Asp Ser Asp Asp Ser Ser Ile Pro Arg Asn Arg Leu Gln Ser Val Val 
        835                 840                 845             


Val Val Pro Lys Asn Ser Thr Leu Pro Met Glu Glu Thr Ser Pro Cys 
    850                 855                 860                 


Ser Ser Arg Ser Ser Gln Ser Tyr Arg His Tyr Ser Asp His Trp Glu 
865                 870                 875                 880 


Asp Glu Arg Leu Glu Ser Arg Arg His Leu Tyr Glu Glu Lys Phe Glu 
                885                 890                 895     


Ser Ile Ala Ser Lys Ala Cys Pro Gln Thr Asp Lys Phe Phe Leu His 
            900                 905                 910         


Lys Gly Thr Glu Lys Asn Pro Glu Ile Ser Phe Thr Gln Ser Ser Arg 
        915                 920                 925             


Lys Gln Ile Asp Asn Arg Leu Pro Glu Leu Ser His Pro Gln Ser Asp 
    930                 935                 940                 


Gly Val Asp Ser Thr Ser His Thr Asp Val Lys Ser Asp Pro Leu Gly 
945                 950                 955                 960 


His Pro Asn Ser Glu Glu Thr Val Lys Ala Lys Ile Pro Ser Arg Gln 
                965                 970                 975     


Gln Glu Glu Leu Pro Ile Tyr Ser Ser Asp Phe Glu Asp Val Pro Asn 
            980                 985                 990         


Lys Ser Trp Gln Gln Thr Thr Phe  Gln Asn Arg Pro Asp  Ser Arg Leu 
        995                 1000                 1005             


Gly Lys  Thr Glu Leu Ser Phe  Ser Ser Ser Cys Glu  Ile Pro His 
    1010                 1015                 1020             


Val Asp  Gly Leu His Ser Ser  Glu Glu Leu Arg Asn  Leu Gly Trp 
    1025                 1030                 1035             


Asp Phe  Ser Gln Glu Lys Pro  Ser Thr Thr Tyr Gln  Gln Pro Asp 
    1040                 1045                 1050             


Ser Ser  Tyr Gly Ala Cys Gly  Gly His Lys Tyr Gln  Gln Asn Ala 
    1055                 1060                 1065             


Glu Gln  Tyr Gly Gly Thr Arg  Asp Tyr Trp Gln Gly  Asn Gly Tyr 
    1070                 1075                 1080             


Trp Asp  Pro Arg Ser Gly Arg  Pro Pro Gly Thr Gly  Val Val Tyr 
    1085                 1090                 1095             


Asp Arg  Thr Gln Gly Gln Val  Pro Asp Ser Leu Thr  Asp Asp Arg 
    1100                 1105                 1110             


Glu Glu  Glu Glu Asn Trp Asp  Gln Gln Asp Gly Ser  His Phe Ser 
    1115                 1120                 1125             


Asp Gln  Ser Asp Lys Phe Leu  Leu Ser Leu Gln Lys  Asp Lys Gly 
    1130                 1135                 1140             


Ser Val  Gln Ala Pro Glu Ile  Ser Ser Asn Ser Ile  Lys Asp Thr 
    1145                 1150                 1155             


Leu Ala  Val Asn Glu Lys Lys  Asp Phe Ser Lys Asn  Leu Glu Lys 
    1160                 1165                 1170             


Asn Asp  Ile Lys Asp Arg Gly  Pro Leu Lys Lys Arg  Arg Gln Glu 
    1175                 1180                 1185             


Ile Glu  Ser Asp Ser Glu Ser  Asp Gly Glu Leu Gln  Asp Arg Lys 
    1190                 1195                 1200             


Lys Val  Arg Val Glu Val Glu  Gln Gly Glu Thr Ser  Val Pro Pro 
    1205                 1210                 1215             


Gly Ser  Ala Leu Val Gly Pro  Ser Cys Val Met Asp  Asp Phe Arg 
    1220                 1225                 1230             


Asp Pro  Gln Arg Trp Lys Glu  Cys Ala Lys Gln Gly  Lys Met Pro 
    1235                 1240                 1245             


Cys Tyr  Phe Asp Leu Ile Glu  Glu Asn Val Tyr Leu  Thr Glu Arg 
    1250                 1255                 1260             


Lys Lys  Asn Lys Ser His Arg  Asp Ile Lys Arg Met  Gln Cys Glu 
    1265                 1270                 1275             


Cys Thr  Pro Leu Ser Lys Asp  Glu Arg Ala Gln Gly  Glu Ile Ala 
    1280                 1285                 1290             


Cys Gly  Glu Asp Cys Leu Asn  Arg Leu Leu Met Ile  Glu Cys Ser 
    1295                 1300                 1305             


Ser Arg  Cys Pro Asn Gly Asp  Tyr Cys Ser Asn Arg  Arg Phe Gln 
    1310                 1315                 1320             


Arg Lys  Gln His Ala Asp Val  Glu Val Ile Leu Thr  Glu Lys Lys 
    1325                 1330                 1335             


Gly Trp  Gly Leu Arg Ala Ala  Lys Asp Leu Pro Ser  
    1340                 1345                 1350 


<210>  9315
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9315
ctaaaatgaa aatggaaatt ggtgatacct tatctactgc agaagaatct tccccaccaa     60

agtcaagggt ggaattgggc aaaattcatt ttaagaaaca tctgcttcat gtaacatcca    120

ggccactgct ggctactacc acagcagtag catctccacc tactcatgca gcaccattac    180

cagcagtgat agcagaatca acaactgtag actcaccgcc ctcatctccg cctccaccgc    240

ctccacctgc ccaagccaca acactctcat caccagcacc agtaacagag ccagtggcct    300

tgccacatac accaataaca gttctaatgg cagcaccagt acccttacca gtagatgtag    360

cagttagatc tctgaaagaa ccaccaatta taattgtacc agaatcttta gaagcagata    420

ctaagcagga cactatatct aatagtttag aagaacacgt aactcaaata ttgaatgagc    480

aagcagatat ttcctcaaaa aaagaagatt cccatattgg gaaggatgaa gaaattccag    540

atagttctaa gattagtctg agctgtaaaa aaacaggttc taagaagaaa tcctcacaat    600

ctgaaggcat ctttcttggt tcagaatctg atgaagattc tgtacggact tcttcaagtc    660

aaagatcaca tgatttaaaa ttttcagcaa gcattgaaaa ggaaagagat tttaaaaaga    720

gctcagcacc tttaaaaagt gaggatctag ggaaaccttc acgatctaaa acagacagag    780

atgataaata ttttagctat tcaaaacttg aaagagatac tcggtatgta tcttcccgat    840

gtagatcaga aagagagcga cggcggagca gatctcactc taggtctgag agaggctcta    900

gaactaattt atcctattcc aggtcagaac gatctcatta ttatgactct gatcgtcgct    960

accataggag ctccccttat cgagagagga cgcgctattc tcggccatac acagataaca   1020

gagcacgaga gagttctgac tcagaagaag agtataagaa gacatactca aggcgtacct   1080

catctcattc ctcttcttac agagacctaa ggacatcatc ctattctaaa tctgatcggg   1140

actgtaaaac tgagacctct tacttagaga tggaaagaag aggcaagtat tcttcaaaac   1200

tagaaagaga atctaaaagg acttcagaaa atgaagcaat taaaagatgt tgttctcccc   1260

ctaatgaact gggattccga cgagggtcat catattctaa gcatgacagt agtgcttccc   1320

gttataaatc taccctttca aaacctatac ccaagtctga taaatttaaa aattctttct   1380

gttgtacaga attaaatgaa gaaatcaaac agtctcattc ttttagttta cagacacctt   1440

gttcaaaagg tagtgaatta agaatgatta ataaaaatcc tgaaagagaa aaggctgggt   1500

ctccagctcc atcaaatcga ttaaatgatt cacctacttt aaaaaagcta gatgaattgc   1560

ctatttttaa gtccgaattt ataacacatg atagccatga tagtattaag gaattagact   1620

ctttatctaa agtgaagaat gatcaattaa gaagtttttg tcccatagaa ttaaatataa   1680

atggatctcc tggggcagaa tctgatttgg caacattttg cacttctaaa actgatgctg   1740

ttttaatgac ttctgatgat agtgtgactg gatcggaatt atcccctttg gtcaaagcat   1800

gcatgctttc atcaaatgga tttcagaata ttagtaggtg caaagaaaaa gacttggatg   1860

atacctgcat gctgcataag aagtcagaaa gcccatttag agaaacagaa cctctggtgt   1920

caccacacca agataaactc atgtctatgc cagttatgac tgtggattat tccaaaacag   1980

tagttaaaga accagttgat acgagggttt cttgctgcaa aaccaaagat tcagacatat   2040

actgtacttt gaacgatagc aacccttctt tgtgtaactc tgaagctgaa aatattgagc   2100

cttcagttat gaagatttct tcaaatagct ttatgaatgt gcatttggaa tcaaaaccag   2160

ttatatgtga tagtagaaat ttgacagatc actcaaaatt tgcatgtgaa gaatataagc   2220

agagcatcgg tagcactagt tcagcttctg ttaatcattt tgatgattta tatcaaccta   2280

ttgggagttc aggtattgct tcatctcttc agagtcttcc accaggaata aaggtggaca   2340

gtctaactct cttgaaatgc ggagagaaca catctccagt tctggatgca gtgctaaaga   2400

gtaaaaaaag ttcagagttt ttaaagcatg cagggaaaga aacaatagta gaagtaggta   2460

gtgaccttcc tgattcagga aagggatttg cttccaggga gaacaggcgt aataatgggt   2520

tatctgggaa atgtttgcaa gaggctcaag aagaagggaa ttccatattg cctgaaagaa   2580

gaggaagacc agaaatctct ttagatgaaa gaggagaagg aggacatgtg catacttctg   2640

atgactcaga agttgtattt tcttcttgtg atttgaattt aaccatggaa gacagtgatg   2700

gtgtaactta tgcattaaag tgtgacagta gtggtcatgc cccagaaatt gtgtctacag   2760

ttcatgaaga ttattctggc tcttctgaaa gttcaaatga tgaaagtgat tcagaagata   2820

cagattcgga tgatagcagt attccaagaa accgtctcca gtctgttgtg gttgtgccaa   2880

agaattctac tttgcccatg gaagaaacaa gtccttgttc ttctcggagc agtcaaagtt   2940

atagacacta ttctgaccat tgggaagatg agagattgga gtcaaggaga catttgtatg   3000

aggaaaaatt tgaaagtata gcaagtaaag cctgtcctca aactgataag tttttccttc   3060

ataaaggaac agagaagaat ccggaaattt cttttacaca gtccagtaga aaacaaatag   3120

ataatcgcct gcctgaactt tctcatcctc agagtgatgg ggttgatagt acaagtcata   3180

cagatgtgaa atctgaccct ctgggtcacc caaattcaga ggaaaccgtg aaagccaaaa   3240

taccttctag gcagcaagaa gagctgccaa tttattcttc tgattttgaa gatgtcccaa   3300

ataagtcttg gcaacagacc actttccaaa acaggccaga tagtagactg ggaaaaacag   3360

aattgagttt ttcttcctct tgtgagatac cacatgtgga tggcttgcac tcatcagaag   3420

agctcagaaa cttaggttgg gacttctctc aagaaaagcc ttctaccacg tatcagcaac   3480

ctgacagtag ctatggagct tgtggtggac acaagtatca gcaaaatgca gaacagtatg   3540

gtgggacacg tgattactgg caaggcaatg gttactggga tccaagatca ggtagacctc   3600

ctggaactgg ggttgtgtat gatcgaactc aaggacaagt accagattcc ctaacagatg   3660

atcgtgaaga agaggagaat tgggatcaac aggatggatc ccatttttca gaccagtccg   3720

ataaatttct tctatccctt cagaaagaca aggggtcagt gcaagcacct gaaataagca   3780

gcaattccat taaggacact ttagctgtga atgaaaagaa agatttttca aaaaacttag   3840

aaaaaaatga tatcaaagat agagggcctc ttaaaaaaag gaggcaggaa atagagagtg   3900

attctgaaag tgatggtgag cttcaggaca gaaagaaagt tagagtggag gtagagcagg   3960

gagagacatc agtgccccca ggttcagcac tggttgggcc ctcctgtgtc atggatgact   4020

tcagggaccc acagcgatgg aaggaatgtg ccaagcaagg gaaaatgcca tgttactttg   4080

atcttattga agaaaatgtt tatttaacag aaagaatgaa gtatctttgg gtactgtatt   4140

agtccgtttt catgctgctg ataaagacat acccgagact gggaagaaaa agaggtttaa   4200

ttggacttgc agttccacat ggctggggag gcctcagaat tgcggcagga ggcaaaaggc   4260

acttcttaca tggtggtggc aagagaaaaa gaggaagaag caaaagtgaa aacccttgat   4320

aaacccatca gatcttgtgt gacttaatca ccatcacaag aataacacga gaaaggccgg   4380

cccccatgat tcagttacct cctcaagttg agtttgggtg gggaaacagc caaaccatat   4440

cagaaagaag aataaatctc atcgagatat taagcgaatg cagtgtgagt gtacacctct   4500

ttctaaagat gaaagagctc aaggtgaaat agcatgtggg gaagattgtc ttaatcgtct   4560

tctcatgatt gaatgttctt ctcggtgtcc aaatggggat tattgttcca atagacggtt   4620

tcagagaaaa cagcatgcag atgtggaagt catactcaca gaaaagaaag gctggggctt   4680

gagagctgcc aaagaccttc cttcataata gatgccactc aaaaaggaaa ttgctctcgt   4740

ttcatgaatc acagctgtga accaaattgt gaaacccaaa aatggactgt gaacggacaa   4800

ctgagggttg ggttttttac caccaaactg gttccttcag gctcagagtt aacgtttgac   4860

tatcagttcc agagatatgg aaaagaagcc cagaaatgtt tctgcggatc agccaattgc   4920

cggggttacc tgggaggaga aaacagagtc agcatcagag cagcaggagg gaaaatgaag   4980

aaggaacgat ctcgtaagaa ggattcagtg gatggagagc tagaagctct gatggaaaat   5040

ggtgagggtc tctctgataa aaaccaggtg ctcagcttat cccggctaat ggttagaatt   5100

gaaactttgg agcagaaact tacctgtctg gaactcatac agaacacaca ctcacagtcc   5160

tgcctgaagt cctttctgga acgtcatggg ctgtctttgt tgtggatctg gatggcagag   5220

ctaggtgacg gccgggaaag taaccagaag cttcaggaag agattataaa gactttggaa   5280

cacttgccca ttcctactaa aaatatgttg gaggaaagca aagtacttcc aattattcaa   5340

cgctggtctc agactaagac tgctgtccct ccgttgagtg aaggagatgg gtattctagt   5400

gagaatacat cgcgtgctca tacaccactc aacacacctg atccttccac caagctgagc   5460

acagaagctg acacagacac tcccaagaaa ctaatgtttc gcagactgaa aattataagt   5520

gaaaatagca tggacagtgc aatctctgat gcaaccagtg agctagaagg caaggatggc   5580

aaagaggatc ttgatcaatt agaaaatgtc cctgtagagg aagaggaaga attgcagtca   5640

caacagctac tcccacaaca gctgcctgaa tgcaaagttg atagtgaaac caacatagaa   5700

gctagtaagc tacctacatc tgaaccagaa gctgacgctg aaatagagcc caaagagagc   5760

aacggcacaa aactagaaga acctattaat gaagaaacac catcccaaga tgaagaggag   5820

ggtgtgtctg atgtggagag tgaaaggagc caagaacagc cagataaaac agtggatata   5880

agtgatttgg ccaccaaact cctggacagt tggaaagacc taaaggaggt atatcgaatt   5940

ccaaagaaaa gtcaaactga aaaggaaaac acaacaactg aacgaggaag ggatgctgtt   6000

ggcttcagag atcaaacacc tgccccgaag actcctaata ggtcaagaga gagagaccca   6060

gacaagcaaa ctcaaaataa agagaaaagg aaacgaagaa gctccctctc accaccctct   6120

tctgcctatg agcggggaac aaaaaggcca gatgacagat atgatacacc aacttctaaa   6180

aagaaagtac gaattaaaga ccgcaataaa ctttctacag aggaacgccg gaagttgttt   6240

gagcaagagg tggctcaacg ggaggctcag aaacaacagc aacagatgca gaacctggga   6300

atgacatcac cactgcccta tgactctctt ggttataatg ccccgcatca tccctttgct   6360

ggttacccac caggttatcc catgcaggcc tatgtggatc ccagcaaccc taatgctgga   6420

aaggtgctcc tgcccacacc cagcatggac ccagtgtgtt ctcctgctcc ttatgatcat   6480

gctcagccct tggtgggaca ttctacagaa cccctttctg cccctccacc agtaccagtg   6540

gtgccacatg tggcagctcc tgtggaagtt tccagttccc agtatgtggc ccagagtgat   6600

ggtgtagtac accaagactc cagcgttgct gtcttgccag tgccggcccc cggcccagtt   6660

cagggacaga attatagtgt ttgggattca aaccaacagt ctgtcagtgt acagcagcag   6720

tactctcctg cacagtctca agcaaccata tattatcaag gacagacatg tccaacagtc   6780

tatggtgtga catcacctta ttcacagaca actccaccaa ttgtacagag ttatgcccag   6840

ccaagtcttc agtatatcca ggggcaacag attttcacag ctcatccaca aggagtggtg   6900

gtacagccag ccgcagcagt gactacaata gttgcaccag ggcagcctca gcccttgcag   6960

ccatctgaaa tggttgtgac aaataatctc ttggatctgc cgcccccctc tcctcccaaa   7020

ccaaaaacca ttgtcttacc tcccaactgg aagacagctc gagatccaga agggaagatt   7080

tattactacc atgtgatcac aaggcagact cagtgggatc ctcctacttg ggaaagccca   7140

ggagatgatg ccagccttga gcatgaagct gagatggacc tgggaactcc aacatatgat   7200

gaaaacccca tgaaggcctc gaaaaagccc aagacagcag aagcagacac ctccagtgaa   7260

ctagcaaaga aaagcaaaga agtattcaga aaagagatgt cccagttcat cgtccagtgc   7320

ctgaaccctt accggaaacc tgactgcaaa gtgggaagaa ttaccacaac tgaagacttt   7380

aaacatctgg ctcgcaagct gactcacggt gttatgaata aggagctgaa gtactgtaag   7440

aatcctgagg acctggagtg caatgagaat gtgaaacaca aaaccaagga gtacattaag   7500

aagtacatgc agaagtttgg ggctgtttac aaacccaaag aggacactga attagagtga   7560

ctgttgggcc agggtgggag gatgggtggt caggtaagac agactctagg gagaggaaat   7620

cctgtgggcc tttctgtccc acccctgtca gcactgtgct actgatgata catcaccctg   7680

gggaattcaa ccctgcagat gtcaactgaa ggccacaaaa atgaactcca tctacaagtg   7740

attacctagt tgtgagctgt tggcatgtgg ttagaagcca tcagaggtgc aagggcttag   7800

aaaagaccct ggccagacct gactccactc ttaaacctgg gtcttctcct tggcggtgct   7860

gtcagcgcac agacccatgc gcatccccac ccacaaccct ttaccctgat gatctgtatt   7920

atattttaat gtatatgtga atatattgaa aataatttgt tttttcctgg tttttgtttg   7980

gttttcgttt tgcttttagc ctctacatgc taggatcaca ggaagacttt gtaaggacag   8040

tttaagttct cctgcaaggt ttaatttgtt atcatgtaaa tattctaaag caggctgcct   8100

tgtggttttg gccagccttg tgctatgttg ataagattga tttactgctt aaaatcactt   8160

tactttatcc aatttttact gaacttttta tg                                 8192


<210>  9316
<211>  1378
<212>  PRT
<213>  Homosapiens

<400>  9316

Met Lys Met Glu Ile Gly Asp Thr Leu Ser Thr Ala Glu Glu Ser Ser 
1               5                   10                  15      


Pro Pro Lys Ser Arg Val Glu Leu Gly Lys Ile His Phe Lys Lys His 
            20                  25                  30          


Leu Leu His Val Thr Ser Arg Pro Leu Leu Ala Thr Thr Thr Ala Val 
        35                  40                  45              


Ala Ser Pro Pro Thr His Ala Ala Pro Leu Pro Ala Val Ile Ala Glu 
    50                  55                  60                  


Ser Thr Thr Val Asp Ser Pro Pro Ser Ser Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Ala Gln Ala Thr Thr Leu Ser Ser Pro Ala Pro Val Thr Glu Pro 
                85                  90                  95      


Val Ala Leu Pro His Thr Pro Ile Thr Val Leu Met Ala Ala Pro Val 
            100                 105                 110         


Pro Leu Pro Val Asp Val Ala Val Arg Ser Leu Lys Glu Pro Pro Ile 
        115                 120                 125             


Ile Ile Val Pro Glu Ser Leu Glu Ala Asp Thr Lys Gln Asp Thr Ile 
    130                 135                 140                 


Ser Asn Ser Leu Glu Glu His Val Thr Gln Ile Leu Asn Glu Gln Ala 
145                 150                 155                 160 


Asp Ile Ser Ser Lys Lys Glu Asp Ser His Ile Gly Lys Asp Glu Glu 
                165                 170                 175     


Ile Pro Asp Ser Ser Lys Ile Ser Leu Ser Cys Lys Lys Thr Gly Ser 
            180                 185                 190         


Lys Lys Lys Ser Ser Gln Ser Glu Gly Ile Phe Leu Gly Ser Glu Ser 
        195                 200                 205             


Asp Glu Asp Ser Val Arg Thr Ser Ser Ser Gln Arg Ser His Asp Leu 
    210                 215                 220                 


Lys Phe Ser Ala Ser Ile Glu Lys Glu Arg Asp Phe Lys Lys Ser Ser 
225                 230                 235                 240 


Ala Pro Leu Lys Ser Glu Asp Leu Gly Lys Pro Ser Arg Ser Lys Thr 
                245                 250                 255     


Asp Arg Asp Asp Lys Tyr Phe Ser Tyr Ser Lys Leu Glu Arg Asp Thr 
            260                 265                 270         


Arg Tyr Val Ser Ser Arg Cys Arg Ser Glu Arg Glu Arg Arg Arg Ser 
        275                 280                 285             


Arg Ser His Ser Arg Ser Glu Arg Gly Ser Arg Thr Asn Leu Ser Tyr 
    290                 295                 300                 


Ser Arg Ser Glu Arg Ser His Tyr Tyr Asp Ser Asp Arg Arg Tyr His 
305                 310                 315                 320 


Arg Ser Ser Pro Tyr Arg Glu Arg Thr Arg Tyr Ser Arg Pro Tyr Thr 
                325                 330                 335     


Asp Asn Arg Ala Arg Glu Ser Ser Asp Ser Glu Glu Glu Tyr Lys Lys 
            340                 345                 350         


Thr Tyr Ser Arg Arg Thr Ser Ser His Ser Ser Ser Tyr Arg Asp Leu 
        355                 360                 365             


Arg Thr Ser Ser Tyr Ser Lys Ser Asp Arg Asp Cys Lys Thr Glu Thr 
    370                 375                 380                 


Ser Tyr Leu Glu Met Glu Arg Arg Gly Lys Tyr Ser Ser Lys Leu Glu 
385                 390                 395                 400 


Arg Glu Ser Lys Arg Thr Ser Glu Asn Glu Ala Ile Lys Arg Cys Cys 
                405                 410                 415     


Ser Pro Pro Asn Glu Leu Gly Phe Arg Arg Gly Ser Ser Tyr Ser Lys 
            420                 425                 430         


His Asp Ser Ser Ala Ser Arg Tyr Lys Ser Thr Leu Ser Lys Pro Ile 
        435                 440                 445             


Pro Lys Ser Asp Lys Phe Lys Asn Ser Phe Cys Cys Thr Glu Leu Asn 
    450                 455                 460                 


Glu Glu Ile Lys Gln Ser His Ser Phe Ser Leu Gln Thr Pro Cys Ser 
465                 470                 475                 480 


Lys Gly Ser Glu Leu Arg Met Ile Asn Lys Asn Pro Glu Arg Glu Lys 
                485                 490                 495     


Ala Gly Ser Pro Ala Pro Ser Asn Arg Leu Asn Asp Ser Pro Thr Leu 
            500                 505                 510         


Lys Lys Leu Asp Glu Leu Pro Ile Phe Lys Ser Glu Phe Ile Thr His 
        515                 520                 525             


Asp Ser His Asp Ser Ile Lys Glu Leu Asp Ser Leu Ser Lys Val Lys 
    530                 535                 540                 


Asn Asp Gln Leu Arg Ser Phe Cys Pro Ile Glu Leu Asn Ile Asn Gly 
545                 550                 555                 560 


Ser Pro Gly Ala Glu Ser Asp Leu Ala Thr Phe Cys Thr Ser Lys Thr 
                565                 570                 575     


Asp Ala Val Leu Met Thr Ser Asp Asp Ser Val Thr Gly Ser Glu Leu 
            580                 585                 590         


Ser Pro Leu Val Lys Ala Cys Met Leu Ser Ser Asn Gly Phe Gln Asn 
        595                 600                 605             


Ile Ser Arg Cys Lys Glu Lys Asp Leu Asp Asp Thr Cys Met Leu His 
    610                 615                 620                 


Lys Lys Ser Glu Ser Pro Phe Arg Glu Thr Glu Pro Leu Val Ser Pro 
625                 630                 635                 640 


His Gln Asp Lys Leu Met Ser Met Pro Val Met Thr Val Asp Tyr Ser 
                645                 650                 655     


Lys Thr Val Val Lys Glu Pro Val Asp Thr Arg Val Ser Cys Cys Lys 
            660                 665                 670         


Thr Lys Asp Ser Asp Ile Tyr Cys Thr Leu Asn Asp Ser Asn Pro Ser 
        675                 680                 685             


Leu Cys Asn Ser Glu Ala Glu Asn Ile Glu Pro Ser Val Met Lys Ile 
    690                 695                 700                 


Ser Ser Asn Ser Phe Met Asn Val His Leu Glu Ser Lys Pro Val Ile 
705                 710                 715                 720 


Cys Asp Ser Arg Asn Leu Thr Asp His Ser Lys Phe Ala Cys Glu Glu 
                725                 730                 735     


Tyr Lys Gln Ser Ile Gly Ser Thr Ser Ser Ala Ser Val Asn His Phe 
            740                 745                 750         


Asp Asp Leu Tyr Gln Pro Ile Gly Ser Ser Gly Ile Ala Ser Ser Leu 
        755                 760                 765             


Gln Ser Leu Pro Pro Gly Ile Lys Val Asp Ser Leu Thr Leu Leu Lys 
    770                 775                 780                 


Cys Gly Glu Asn Thr Ser Pro Val Leu Asp Ala Val Leu Lys Ser Lys 
785                 790                 795                 800 


Lys Ser Ser Glu Phe Leu Lys His Ala Gly Lys Glu Thr Ile Val Glu 
                805                 810                 815     


Val Gly Ser Asp Leu Pro Asp Ser Gly Lys Gly Phe Ala Ser Arg Glu 
            820                 825                 830         


Asn Arg Arg Asn Asn Gly Leu Ser Gly Lys Cys Leu Gln Glu Ala Gln 
        835                 840                 845             


Glu Glu Gly Asn Ser Ile Leu Pro Glu Arg Arg Gly Arg Pro Glu Ile 
    850                 855                 860                 


Ser Leu Asp Glu Arg Gly Glu Gly Gly His Val His Thr Ser Asp Asp 
865                 870                 875                 880 


Ser Glu Val Val Phe Ser Ser Cys Asp Leu Asn Leu Thr Met Glu Asp 
                885                 890                 895     


Ser Asp Gly Val Thr Tyr Ala Leu Lys Cys Asp Ser Ser Gly His Ala 
            900                 905                 910         


Pro Glu Ile Val Ser Thr Val His Glu Asp Tyr Ser Gly Ser Ser Glu 
        915                 920                 925             


Ser Ser Asn Asp Glu Ser Asp Ser Glu Asp Thr Asp Ser Asp Asp Ser 
    930                 935                 940                 


Ser Ile Pro Arg Asn Arg Leu Gln Ser Val Val Val Val Pro Lys Asn 
945                 950                 955                 960 


Ser Thr Leu Pro Met Glu Glu Thr Ser Pro Cys Ser Ser Arg Ser Ser 
                965                 970                 975     


Gln Ser Tyr Arg His Tyr Ser Asp His Trp Glu Asp Glu Arg Leu Glu 
            980                 985                 990         


Ser Arg Arg His Leu Tyr Glu Glu  Lys Phe Glu Ser Ile  Ala Ser Lys 
        995                 1000                 1005             


Ala Cys  Pro Gln Thr Asp Lys  Phe Phe Leu His Lys  Gly Thr Glu 
    1010                 1015                 1020             


Lys Asn  Pro Glu Ile Ser Phe  Thr Gln Ser Ser Arg  Lys Gln Ile 
    1025                 1030                 1035             


Asp Asn  Arg Leu Pro Glu Leu  Ser His Pro Gln Ser  Asp Gly Val 
    1040                 1045                 1050             


Asp Ser  Thr Ser His Thr Asp  Val Lys Ser Asp Pro  Leu Gly His 
    1055                 1060                 1065             


Pro Asn  Ser Glu Glu Thr Val  Lys Ala Lys Ile Pro  Ser Arg Gln 
    1070                 1075                 1080             


Gln Glu  Glu Leu Pro Ile Tyr  Ser Ser Asp Phe Glu  Asp Val Pro 
    1085                 1090                 1095             


Asn Lys  Ser Trp Gln Gln Thr  Thr Phe Gln Asn Arg  Pro Asp Ser 
    1100                 1105                 1110             


Arg Leu  Gly Lys Thr Glu Leu  Ser Phe Ser Ser Ser  Cys Glu Ile 
    1115                 1120                 1125             


Pro His  Val Asp Gly Leu His  Ser Ser Glu Glu Leu  Arg Asn Leu 
    1130                 1135                 1140             


Gly Trp  Asp Phe Ser Gln Glu  Lys Pro Ser Thr Thr  Tyr Gln Gln 
    1145                 1150                 1155             


Pro Asp  Ser Ser Tyr Gly Ala  Cys Gly Gly His Lys  Tyr Gln Gln 
    1160                 1165                 1170             


Asn Ala  Glu Gln Tyr Gly Gly  Thr Arg Asp Tyr Trp  Gln Gly Asn 
    1175                 1180                 1185             


Gly Tyr  Trp Asp Pro Arg Ser  Gly Arg Pro Pro Gly  Thr Gly Val 
    1190                 1195                 1200             


Val Tyr  Asp Arg Thr Gln Gly  Gln Val Pro Asp Ser  Leu Thr Asp 
    1205                 1210                 1215             


Asp Arg  Glu Glu Glu Glu Asn  Trp Asp Gln Gln Asp  Gly Ser His 
    1220                 1225                 1230             


Phe Ser  Asp Gln Ser Asp Lys  Phe Leu Leu Ser Leu  Gln Lys Asp 
    1235                 1240                 1245             


Lys Gly  Ser Val Gln Ala Pro  Glu Ile Ser Ser Asn  Ser Ile Lys 
    1250                 1255                 1260             


Asp Thr  Leu Ala Val Asn Glu  Lys Lys Asp Phe Ser  Lys Asn Leu 
    1265                 1270                 1275             


Glu Lys  Asn Asp Ile Lys Asp  Arg Gly Pro Leu Lys  Lys Arg Arg 
    1280                 1285                 1290             


Gln Glu  Ile Glu Ser Asp Ser  Glu Ser Asp Gly Glu  Leu Gln Asp 
    1295                 1300                 1305             


Arg Lys  Lys Val Arg Val Glu  Val Glu Gln Gly Glu  Thr Ser Val 
    1310                 1315                 1320             


Pro Pro  Gly Ser Ala Leu Val  Gly Pro Ser Cys Val  Met Asp Asp 
    1325                 1330                 1335             


Phe Arg  Asp Pro Gln Arg Trp  Lys Glu Cys Ala Lys  Gln Gly Lys 
    1340                 1345                 1350             


Met Pro  Cys Tyr Phe Asp Leu  Ile Glu Glu Asn Val  Tyr Leu Thr 
    1355                 1360                 1365             


Glu Arg  Met Lys Tyr Leu Trp  Val Leu Tyr 
    1370                 1375             


<210>  9317
<211>  7501
<212>  DNA
<213>  Homosapiens

<400>  9317
caacactctc atcaccagca ccagtaacag agccagtggc cttgccacat acaccaataa     60

cagttctaat ggcagcacca gtacccttac cagtagatgt agcagttaga tctctgaaag    120

aaccaccaat tataattgta ccagaatctt tagaagcaga tactaagcag gacactatat    180

ctaatagttt agaagaacac gtaactcaaa tattgaatga gcaagcagat atttcctcaa    240

aaaaagaaga ttcccatatt gggaaggatg aagaaattcc agatagttct aagattagtc    300

tgagctgtaa aaaaacaggt tctaagaaga aatcctcaca atctgaaggc atctttcttg    360

gttcagaatc tgatgaagat tctgtacgga cttcttcaag tcaaagatca catgatttaa    420

aattttcagc aagcattgaa aaggaaagag attttaaaaa gagctcagca cctttaaaaa    480

gtgaggatct agggaaacct tcacgatcta aaacagacag agatgataaa tattttagct    540

attcaaaact tgaaagagat actcggtatg tatcttcccg atgtagatca gaaagagagc    600

gacggcggag cagatctcac tctaggtctg agagaggctc tagaactaat ttatcctatt    660

ccaggtcaga acgatctcat tattatgact ctgatcgtcg ctaccatagg agctcccctt    720

atcgagagag gacgcgctat tctcggccat acacagataa cagagcacga gagagttctg    780

actcagaaga agagtataag aagacatact caaggcgtac ctcatctcat tcctcttctt    840

acagagacct aaggacatca tcctattcta aatctgatcg ggactgtaaa actgagacct    900

cttacttaga gatggaaaga agaggcaagt attcttcaaa actagaaaga gaatctaaaa    960

ggacttcaga aaatgaagca attaaaagat gttgttctcc ccctaatgaa ctgggattcc   1020

gacgagggtc atcatattct aagcatgaca gtagtgcttc ccgttataaa tctacccttt   1080

caaaacctat acccaagtct gataaattta aaaattcttt ctgttgtaca gaattaaatg   1140

aagaaatcaa acagtctcat tcttttagtt tacagacacc ttgttcaaaa ggtagtgaat   1200

taagaatgat taataaaaat cctgaaagag aaaaggctgg gtctccagct ccatcaaatc   1260

gattaaatga ttcacctact ttaaaaaagc tagatgaatt gcctattttt aagtccgaat   1320

ttataacaca tgatagccat gatagtatta aggaattaga ctctttatct aaagtgaaga   1380

atgatcaatt aagaagtttt tgtcccatag aattaaatat aaatggatct cctggggcag   1440

aatctgattt ggcaacattt tgcacttcta aaactgatgc tgttttaatg acttctgatg   1500

atagtgtgac tggatcggaa ttatcccctt tggtcaaagc atgcatgctt tcatcaaatg   1560

gatttcagaa tattagtagg tgcaaagaaa aagacttgga tgatacctgc atgctgcata   1620

agaagtcaga aagcccattt agagaaacag aacctctggt gtcaccacac caagataaac   1680

tcatgtctat gccagttatg actgtggatt attccaaaac agtagttaaa gaaccagttg   1740

atacgagggt ttcttgctgc aaaaccaaag attcagacat atactgtact ttgaacgata   1800

gcaacccttc tttgtgtaac tctgaagctg aaaatattga gccttcagtt atgaagattt   1860

cttcaaatag ctttatgaat gtgcatttgg aatcaaaacc agttatatgt gatagtagaa   1920

atttgacaga tcactcaaaa tttgcatgtg aagaatataa gcagagcatc ggtagcacta   1980

gttcagcttc tgttaatcat tttgatgatt tatatcaacc tattgggagt tcaggtattg   2040

cttcatctct tcagagtctt ccaccaggaa taaaggtgga cagtctaact ctcttgaaat   2100

gcggagagaa cacatctcca gttctggatg cagtgctaaa gagtaaaaaa agttcagagt   2160

ttttaaagca tgcagggaaa gaaacaatag tagaagtagg tagtgacctt cctgattcag   2220

gaaagggatt tgcttccagg gagaacaggc gtaataatgg gttatctggg aaatgtttgc   2280

aagaggctca agaagaaggg aattccatat tgcctgaaag aagaggaaga ccagaaatct   2340

ctttagatga aagaggagaa ggaggacatg tgcatacttc tgatgactca gaagttgtat   2400

tttcttcttg tgatttgaat ttaaccatgg aagacagtga tggtgtaact tatgcattaa   2460

agtgtgacag tagtggtcat gccccagaaa ttgtgtctac agttcatgaa gattattctg   2520

gctcttctga aagttcaaat gatgaaagtg attcagaaga tacagattcg gatgatagca   2580

gtattccaag aaaccgtctc cagtctgttg tggttgtgcc aaagaattct actttgccca   2640

tggaagaaac aagtccttgt tcttctcgga gcagtcaaag ttatagacac tattctgacc   2700

attgggaaga tgagagattg gagtcaagga gacatttgta tgaggaaaaa tttgaaagta   2760

tagcaagtaa agcctgtcct caaactgata agtttttcct tcataaagga acagagaaga   2820

atccggaaat ttcttttaca cagtccagta gaaaacaaat agataatcgc ctgcctgaac   2880

tttctcatcc tcagagtgat ggggttgata gtacaagtca tacagatgtg aaatctgacc   2940

ctctgggtca cccaaattca gaggaaaccg tgaaagccaa aataccttct aggcagcaag   3000

aagagctgcc aatttattct tctgattttg aagatgtccc aaataagtct tggcaacaga   3060

ccactttcca aaacaggcca gatagtagac tgggaaaaac agaattgagt ttttcttcct   3120

cttgtgagat accacatgtg gatggcttgc actcatcaga agagctcaga aacttaggtt   3180

gggacttctc tcaagaaaag ccttctacca cgtatcagca acctgacagt agctatggag   3240

cttgtggtgg acacaagtat cagcaaaatg cagaacagta tggtgggaca cgtgattact   3300

ggcaaggcaa tggttactgg gatccaagat caggtagacc tcctggaact ggggttgtgt   3360

atgatcgaac tcaaggacaa gtaccagatt ccctaacaga tgatcgtgaa gaagaggaga   3420

attgggatca acaggatgga tcccattttt cagaccagtc cgataaattt cttctatccc   3480

ttcagaaaga caaggggtca gtgcaagcac ctgaaataag cagcaattcc attaaggaca   3540

ctttagctgt gaatgaaaag aaagattttt caaaaaactt agaaaaaaat gatatcaaag   3600

atagagggcc tcttaaaaaa aggaggcagg aaatagagag tgattctgaa agtgatggtg   3660

agcttcagga cagaaagaaa gttagagtgg aggtagagca gggagagaca tcagtgcccc   3720

caggttcagc actggttggg ccctcctgtg tcatggatga cttcagggac ccacagcgat   3780

ggaaggaatg tgccaagcaa gggaaaatgc catgttactt tgatcttatt gaagaaaatg   3840

tttatttaac agaaagaaag aagaataaat ctcatcgaga tattaagcga atgcagtgtg   3900

agtgtacacc tctttctaaa gatgaaagag ctcaaggtga aatagcatgt ggggaagatt   3960

gtcttaatcg tcttctcatg attgaatgtt cttctcggtg tccaaatggg gattattgtt   4020

ccaatagacg gtttcagaga aaacagcatg cagatgtgga agtcatactc acagaaaaga   4080

aaggctgggg cttgagagct gccaaagacc ttccttcgaa cacctttgtc ctagaatatt   4140

gtggagaggt actcgatcat aaagagttta aagctcgagt gaaggagtat gcacgaaaca   4200

aaaacatcca ttactatttc atggccctga agaatgatga gataatagat gccactcaaa   4260

aaggaaattg ctctcgtttc atgaatcaca gctgtgaacc aaattgtgaa acccaaaaat   4320

ggactgtgaa cggacaactg agggttgggt tttttaccac caaactggtt ccttcaggct   4380

cagagttaac gtttgactat cagttccaga gatatggaaa agaagcccag aaatgtttct   4440

gcggatcagc caattgccgg ggttacctgg gaggagaaaa cagagtcagc atcagagcag   4500

caggagggaa aatgaagaag gaacgatctc gtaagaagga ttcagtggat ggagagctag   4560

aagctctgat ggaaaatggt gagggtctct ctgataaaaa ccaggtgctc agcttatccc   4620

ggctaatggt tagaattgaa actttggagc agaaacttac ctgtctggaa ctcatacaga   4680

acacacactc acagtcctgc ctgaagtcct ttctggaacg tcatgggctg tctttgttgt   4740

ggatctggat ggcagagcta ggtgacggcc gggaaagtaa ccagaagctt caggaagaga   4800

ttataaagac tttggaacac ttgcccattc ctactaaaaa tatgttggag gaaagcaaag   4860

tacttccaat tattcaacgc tggtctcaga ctaagactgc tgtccctccg ttgagtgaag   4920

gagatgggta ttctagtgag aatacatcgc gtgctcatac accactcaac acacctgatc   4980

cttccaccaa gctgagcaca gaagctgaca cagacactcc caagaaacta atgtttcgca   5040

gactgaaaat tataagtgaa aatagcatgg acagtgcaat ctctgatgca accagtgagc   5100

tagaaggcaa ggatggcaaa gaggatcttg atcaattaga aaatgtccct gtagaggaag   5160

aggaagaatt gcagtcacaa cagctactcc cacaacagct gcctgaatgc aaagttgata   5220

gtgaaaccaa catagaagct agtaagctac ctacatctga accagaagct gacgctgaaa   5280

tagagcccaa agagagcaac ggcacaaaac tagaagaacc tattaatgaa gaaacaccat   5340

cccaagatga agaggagggt gtgtctgatg tggagagtga aaggagccaa gaacagccag   5400

ataaaacagt ggatataagt gatttggcca ccaaactcct ggacagttgg aaagacctaa   5460

aggaggtata tcgaattcca aagaaaagtc aaactgaaaa ggaaaacaca acaactgaac   5520

gaggaaggga tgctgttggc ttcagagatc aaacacctgc cccgaagact cctaataggt   5580

caagagagag agacccagac aagcaaactc aaaataaaga gaaaaggaaa cgaagaagct   5640

ccctctcacc accctcttct gcctatgagc ggggaacaaa aaggccagat gacagatatg   5700

atacaccaac ttctaaaaag aaagtacgaa ttaaagaccg caataaactt tctacagagg   5760

aacgccggaa gttgtttgag caagaggtgg ctcaacggga ggctcagaaa caacagcaac   5820

agatgcagaa cctgggaatg acatcaccac tgccctatga ctctcttggt tataatgccc   5880

cgcatcatcc ctttgctggt tacccaccag gttatcccat gcaggcctat gtggatccca   5940

gcaaccctaa tgctggaaag gtgctcctgc ccacacccag catggaccca gtgtgttctc   6000

ctgctcctta tgatcatgct cagcccttgg tgggacattc tacagaaccc ctttctgccc   6060

ctccaccagt accagtggtg ccacatgtgg cagctcctgt ggaagtttcc agttcccagt   6120

atgtggccca gagtgatggt gtagtacacc aagactccag cgttgctgtc ttgccagtgc   6180

cggcccccgg cccagttcag ggacagaatt atagtgtttg ggattcaaac caacagtctg   6240

tcagtgtaca gcagcagtac tctcctgcac agtctcaagc aaccatatat tatcaaggac   6300

agacatgtcc aacagtctat ggtgtgacat caccttattc acagacaact ccaccaattg   6360

tacagagtta tgcccagcca agtcttcagt atatccaggg gcaacagatt ttcacagctc   6420

atccacaagg agtggtggta cagccagccg cagcagtgac tacaatagtt gcaccagggc   6480

agcctcagcc cttgcagcca tctgaaatgg ttgtgacaaa taatctcttg gatctgccgc   6540

ccccctctcc tcccaaacca aaaaccattg tcttacctcc caactggaag acagctcgag   6600

atccagaagg gaagatttat tactaccatg tgatcacaag gcagactcag tgggatcctc   6660

ctacttggga aagcccagga gatgatgcca gccttgagca tgaagctgag atggacctgg   6720

gaactccaac atatgatgaa aaccccatga aggcctcgaa aaagcccaag acagcagaag   6780

cagacacctc cagtgaacta gcaaagaaaa gcaaagaagt attcagaaaa gagatgtccc   6840

agttcatcgt ccagtgcctg aacccttacc ggaaacctga ctgcaaagtg ggaagaatta   6900

ccacaactga agactttaaa catctggctc gcaagctgac tcacggtgtt atgaataagg   6960

agctgaagta ctgtaagaat cctgaggacc tggagtgcaa tgagaatgtg aaacacaaaa   7020

ccaaggagta cattaagaag tacatgcaga agtttggggc tgtttacaaa cccaaagagg   7080

acactgaatt agagtgactg ttgggccagg gtgggaggat gggtggtcag gtaagacaga   7140

ctctagggag aggaaatcct gtgggccttt ctgtcccacc cctgtcagca ctgtgctact   7200

gatgatacat caccctgggg aattcaaccc tgcagatgtc aactgaaggc cacaaaaatg   7260

aactccatct acaagtgatt acctagttgt gagctgttgg catgtggtta gaagccatca   7320

gaggtgcaag ggcttagaaa agaccctggc cagacctgac tccactctta aacctgggtc   7380

ttctccttgg cggtgctgtc agcgcacaga cccatgcgca tccccaccca caacccttta   7440

ccctgatgat ctgtattata ttttaatgta tatgtgaata tattgaaaat aatttgtttt   7500

t                                                                   7501


<210>  9318
<211>  2342
<212>  PRT
<213>  Homosapiens

<400>  9318

Met Ala Ala Pro Val Pro Leu Pro Val Asp Val Ala Val Arg Ser Leu 
1               5                   10                  15      


Lys Glu Pro Pro Ile Ile Ile Val Pro Glu Ser Leu Glu Ala Asp Thr 
            20                  25                  30          


Lys Gln Asp Thr Ile Ser Asn Ser Leu Glu Glu His Val Thr Gln Ile 
        35                  40                  45              


Leu Asn Glu Gln Ala Asp Ile Ser Ser Lys Lys Glu Asp Ser His Ile 
    50                  55                  60                  


Gly Lys Asp Glu Glu Ile Pro Asp Ser Ser Lys Ile Ser Leu Ser Cys 
65                  70                  75                  80  


Lys Lys Thr Gly Ser Lys Lys Lys Ser Ser Gln Ser Glu Gly Ile Phe 
                85                  90                  95      


Leu Gly Ser Glu Ser Asp Glu Asp Ser Val Arg Thr Ser Ser Ser Gln 
            100                 105                 110         


Arg Ser His Asp Leu Lys Phe Ser Ala Ser Ile Glu Lys Glu Arg Asp 
        115                 120                 125             


Phe Lys Lys Ser Ser Ala Pro Leu Lys Ser Glu Asp Leu Gly Lys Pro 
    130                 135                 140                 


Ser Arg Ser Lys Thr Asp Arg Asp Asp Lys Tyr Phe Ser Tyr Ser Lys 
145                 150                 155                 160 


Leu Glu Arg Asp Thr Arg Tyr Val Ser Ser Arg Cys Arg Ser Glu Arg 
                165                 170                 175     


Glu Arg Arg Arg Ser Arg Ser His Ser Arg Ser Glu Arg Gly Ser Arg 
            180                 185                 190         


Thr Asn Leu Ser Tyr Ser Arg Ser Glu Arg Ser His Tyr Tyr Asp Ser 
        195                 200                 205             


Asp Arg Arg Tyr His Arg Ser Ser Pro Tyr Arg Glu Arg Thr Arg Tyr 
    210                 215                 220                 


Ser Arg Pro Tyr Thr Asp Asn Arg Ala Arg Glu Ser Ser Asp Ser Glu 
225                 230                 235                 240 


Glu Glu Tyr Lys Lys Thr Tyr Ser Arg Arg Thr Ser Ser His Ser Ser 
                245                 250                 255     


Ser Tyr Arg Asp Leu Arg Thr Ser Ser Tyr Ser Lys Ser Asp Arg Asp 
            260                 265                 270         


Cys Lys Thr Glu Thr Ser Tyr Leu Glu Met Glu Arg Arg Gly Lys Tyr 
        275                 280                 285             


Ser Ser Lys Leu Glu Arg Glu Ser Lys Arg Thr Ser Glu Asn Glu Ala 
    290                 295                 300                 


Ile Lys Arg Cys Cys Ser Pro Pro Asn Glu Leu Gly Phe Arg Arg Gly 
305                 310                 315                 320 


Ser Ser Tyr Ser Lys His Asp Ser Ser Ala Ser Arg Tyr Lys Ser Thr 
                325                 330                 335     


Leu Ser Lys Pro Ile Pro Lys Ser Asp Lys Phe Lys Asn Ser Phe Cys 
            340                 345                 350         


Cys Thr Glu Leu Asn Glu Glu Ile Lys Gln Ser His Ser Phe Ser Leu 
        355                 360                 365             


Gln Thr Pro Cys Ser Lys Gly Ser Glu Leu Arg Met Ile Asn Lys Asn 
    370                 375                 380                 


Pro Glu Arg Glu Lys Ala Gly Ser Pro Ala Pro Ser Asn Arg Leu Asn 
385                 390                 395                 400 


Asp Ser Pro Thr Leu Lys Lys Leu Asp Glu Leu Pro Ile Phe Lys Ser 
                405                 410                 415     


Glu Phe Ile Thr His Asp Ser His Asp Ser Ile Lys Glu Leu Asp Ser 
            420                 425                 430         


Leu Ser Lys Val Lys Asn Asp Gln Leu Arg Ser Phe Cys Pro Ile Glu 
        435                 440                 445             


Leu Asn Ile Asn Gly Ser Pro Gly Ala Glu Ser Asp Leu Ala Thr Phe 
    450                 455                 460                 


Cys Thr Ser Lys Thr Asp Ala Val Leu Met Thr Ser Asp Asp Ser Val 
465                 470                 475                 480 


Thr Gly Ser Glu Leu Ser Pro Leu Val Lys Ala Cys Met Leu Ser Ser 
                485                 490                 495     


Asn Gly Phe Gln Asn Ile Ser Arg Cys Lys Glu Lys Asp Leu Asp Asp 
            500                 505                 510         


Thr Cys Met Leu His Lys Lys Ser Glu Ser Pro Phe Arg Glu Thr Glu 
        515                 520                 525             


Pro Leu Val Ser Pro His Gln Asp Lys Leu Met Ser Met Pro Val Met 
    530                 535                 540                 


Thr Val Asp Tyr Ser Lys Thr Val Val Lys Glu Pro Val Asp Thr Arg 
545                 550                 555                 560 


Val Ser Cys Cys Lys Thr Lys Asp Ser Asp Ile Tyr Cys Thr Leu Asn 
                565                 570                 575     


Asp Ser Asn Pro Ser Leu Cys Asn Ser Glu Ala Glu Asn Ile Glu Pro 
            580                 585                 590         


Ser Val Met Lys Ile Ser Ser Asn Ser Phe Met Asn Val His Leu Glu 
        595                 600                 605             


Ser Lys Pro Val Ile Cys Asp Ser Arg Asn Leu Thr Asp His Ser Lys 
    610                 615                 620                 


Phe Ala Cys Glu Glu Tyr Lys Gln Ser Ile Gly Ser Thr Ser Ser Ala 
625                 630                 635                 640 


Ser Val Asn His Phe Asp Asp Leu Tyr Gln Pro Ile Gly Ser Ser Gly 
                645                 650                 655     


Ile Ala Ser Ser Leu Gln Ser Leu Pro Pro Gly Ile Lys Val Asp Ser 
            660                 665                 670         


Leu Thr Leu Leu Lys Cys Gly Glu Asn Thr Ser Pro Val Leu Asp Ala 
        675                 680                 685             


Val Leu Lys Ser Lys Lys Ser Ser Glu Phe Leu Lys His Ala Gly Lys 
    690                 695                 700                 


Glu Thr Ile Val Glu Val Gly Ser Asp Leu Pro Asp Ser Gly Lys Gly 
705                 710                 715                 720 


Phe Ala Ser Arg Glu Asn Arg Arg Asn Asn Gly Leu Ser Gly Lys Cys 
                725                 730                 735     


Leu Gln Glu Ala Gln Glu Glu Gly Asn Ser Ile Leu Pro Glu Arg Arg 
            740                 745                 750         


Gly Arg Pro Glu Ile Ser Leu Asp Glu Arg Gly Glu Gly Gly His Val 
        755                 760                 765             


His Thr Ser Asp Asp Ser Glu Val Val Phe Ser Ser Cys Asp Leu Asn 
    770                 775                 780                 


Leu Thr Met Glu Asp Ser Asp Gly Val Thr Tyr Ala Leu Lys Cys Asp 
785                 790                 795                 800 


Ser Ser Gly His Ala Pro Glu Ile Val Ser Thr Val His Glu Asp Tyr 
                805                 810                 815     


Ser Gly Ser Ser Glu Ser Ser Asn Asp Glu Ser Asp Ser Glu Asp Thr 
            820                 825                 830         


Asp Ser Asp Asp Ser Ser Ile Pro Arg Asn Arg Leu Gln Ser Val Val 
        835                 840                 845             


Val Val Pro Lys Asn Ser Thr Leu Pro Met Glu Glu Thr Ser Pro Cys 
    850                 855                 860                 


Ser Ser Arg Ser Ser Gln Ser Tyr Arg His Tyr Ser Asp His Trp Glu 
865                 870                 875                 880 


Asp Glu Arg Leu Glu Ser Arg Arg His Leu Tyr Glu Glu Lys Phe Glu 
                885                 890                 895     


Ser Ile Ala Ser Lys Ala Cys Pro Gln Thr Asp Lys Phe Phe Leu His 
            900                 905                 910         


Lys Gly Thr Glu Lys Asn Pro Glu Ile Ser Phe Thr Gln Ser Ser Arg 
        915                 920                 925             


Lys Gln Ile Asp Asn Arg Leu Pro Glu Leu Ser His Pro Gln Ser Asp 
    930                 935                 940                 


Gly Val Asp Ser Thr Ser His Thr Asp Val Lys Ser Asp Pro Leu Gly 
945                 950                 955                 960 


His Pro Asn Ser Glu Glu Thr Val Lys Ala Lys Ile Pro Ser Arg Gln 
                965                 970                 975     


Gln Glu Glu Leu Pro Ile Tyr Ser Ser Asp Phe Glu Asp Val Pro Asn 
            980                 985                 990         


Lys Ser Trp Gln Gln Thr Thr Phe  Gln Asn Arg Pro Asp  Ser Arg Leu 
        995                 1000                 1005             


Gly Lys  Thr Glu Leu Ser Phe  Ser Ser Ser Cys Glu  Ile Pro His 
    1010                 1015                 1020             


Val Asp  Gly Leu His Ser Ser  Glu Glu Leu Arg Asn  Leu Gly Trp 
    1025                 1030                 1035             


Asp Phe  Ser Gln Glu Lys Pro  Ser Thr Thr Tyr Gln  Gln Pro Asp 
    1040                 1045                 1050             


Ser Ser  Tyr Gly Ala Cys Gly  Gly His Lys Tyr Gln  Gln Asn Ala 
    1055                 1060                 1065             


Glu Gln  Tyr Gly Gly Thr Arg  Asp Tyr Trp Gln Gly  Asn Gly Tyr 
    1070                 1075                 1080             


Trp Asp  Pro Arg Ser Gly Arg  Pro Pro Gly Thr Gly  Val Val Tyr 
    1085                 1090                 1095             


Asp Arg  Thr Gln Gly Gln Val  Pro Asp Ser Leu Thr  Asp Asp Arg 
    1100                 1105                 1110             


Glu Glu  Glu Glu Asn Trp Asp  Gln Gln Asp Gly Ser  His Phe Ser 
    1115                 1120                 1125             


Asp Gln  Ser Asp Lys Phe Leu  Leu Ser Leu Gln Lys  Asp Lys Gly 
    1130                 1135                 1140             


Ser Val  Gln Ala Pro Glu Ile  Ser Ser Asn Ser Ile  Lys Asp Thr 
    1145                 1150                 1155             


Leu Ala  Val Asn Glu Lys Lys  Asp Phe Ser Lys Asn  Leu Glu Lys 
    1160                 1165                 1170             


Asn Asp  Ile Lys Asp Arg Gly  Pro Leu Lys Lys Arg  Arg Gln Glu 
    1175                 1180                 1185             


Ile Glu  Ser Asp Ser Glu Ser  Asp Gly Glu Leu Gln  Asp Arg Lys 
    1190                 1195                 1200             


Lys Val  Arg Val Glu Val Glu  Gln Gly Glu Thr Ser  Val Pro Pro 
    1205                 1210                 1215             


Gly Ser  Ala Leu Val Gly Pro  Ser Cys Val Met Asp  Asp Phe Arg 
    1220                 1225                 1230             


Asp Pro  Gln Arg Trp Lys Glu  Cys Ala Lys Gln Gly  Lys Met Pro 
    1235                 1240                 1245             


Cys Tyr  Phe Asp Leu Ile Glu  Glu Asn Val Tyr Leu  Thr Glu Arg 
    1250                 1255                 1260             


Lys Lys  Asn Lys Ser His Arg  Asp Ile Lys Arg Met  Gln Cys Glu 
    1265                 1270                 1275             


Cys Thr  Pro Leu Ser Lys Asp  Glu Arg Ala Gln Gly  Glu Ile Ala 
    1280                 1285                 1290             


Cys Gly  Glu Asp Cys Leu Asn  Arg Leu Leu Met Ile  Glu Cys Ser 
    1295                 1300                 1305             


Ser Arg  Cys Pro Asn Gly Asp  Tyr Cys Ser Asn Arg  Arg Phe Gln 
    1310                 1315                 1320             


Arg Lys  Gln His Ala Asp Val  Glu Val Ile Leu Thr  Glu Lys Lys 
    1325                 1330                 1335             


Gly Trp  Gly Leu Arg Ala Ala  Lys Asp Leu Pro Ser  Asn Thr Phe 
    1340                 1345                 1350             


Val Leu  Glu Tyr Cys Gly Glu  Val Leu Asp His Lys  Glu Phe Lys 
    1355                 1360                 1365             


Ala Arg  Val Lys Glu Tyr Ala  Arg Asn Lys Asn Ile  His Tyr Tyr 
    1370                 1375                 1380             


Phe Met  Ala Leu Lys Asn Asp  Glu Ile Ile Asp Ala  Thr Gln Lys 
    1385                 1390                 1395             


Gly Asn  Cys Ser Arg Phe Met  Asn His Ser Cys Glu  Pro Asn Cys 
    1400                 1405                 1410             


Glu Thr  Gln Lys Trp Thr Val  Asn Gly Gln Leu Arg  Val Gly Phe 
    1415                 1420                 1425             


Phe Thr  Thr Lys Leu Val Pro  Ser Gly Ser Glu Leu  Thr Phe Asp 
    1430                 1435                 1440             


Tyr Gln  Phe Gln Arg Tyr Gly  Lys Glu Ala Gln Lys  Cys Phe Cys 
    1445                 1450                 1455             


Gly Ser  Ala Asn Cys Arg Gly  Tyr Leu Gly Gly Glu  Asn Arg Val 
    1460                 1465                 1470             


Ser Ile  Arg Ala Ala Gly Gly  Lys Met Lys Lys Glu  Arg Ser Arg 
    1475                 1480                 1485             


Lys Lys  Asp Ser Val Asp Gly  Glu Leu Glu Ala Leu  Met Glu Asn 
    1490                 1495                 1500             


Gly Glu  Gly Leu Ser Asp Lys  Asn Gln Val Leu Ser  Leu Ser Arg 
    1505                 1510                 1515             


Leu Met  Val Arg Ile Glu Thr  Leu Glu Gln Lys Leu  Thr Cys Leu 
    1520                 1525                 1530             


Glu Leu  Ile Gln Asn Thr His  Ser Gln Ser Cys Leu  Lys Ser Phe 
    1535                 1540                 1545             


Leu Glu  Arg His Gly Leu Ser  Leu Leu Trp Ile Trp  Met Ala Glu 
    1550                 1555                 1560             


Leu Gly  Asp Gly Arg Glu Ser  Asn Gln Lys Leu Gln  Glu Glu Ile 
    1565                 1570                 1575             


Ile Lys  Thr Leu Glu His Leu  Pro Ile Pro Thr Lys  Asn Met Leu 
    1580                 1585                 1590             


Glu Glu  Ser Lys Val Leu Pro  Ile Ile Gln Arg Trp  Ser Gln Thr 
    1595                 1600                 1605             


Lys Thr  Ala Val Pro Pro Leu  Ser Glu Gly Asp Gly  Tyr Ser Ser 
    1610                 1615                 1620             


Glu Asn  Thr Ser Arg Ala His  Thr Pro Leu Asn Thr  Pro Asp Pro 
    1625                 1630                 1635             


Ser Thr  Lys Leu Ser Thr Glu  Ala Asp Thr Asp Thr  Pro Lys Lys 
    1640                 1645                 1650             


Leu Met  Phe Arg Arg Leu Lys  Ile Ile Ser Glu Asn  Ser Met Asp 
    1655                 1660                 1665             


Ser Ala  Ile Ser Asp Ala Thr  Ser Glu Leu Glu Gly  Lys Asp Gly 
    1670                 1675                 1680             


Lys Glu  Asp Leu Asp Gln Leu  Glu Asn Val Pro Val  Glu Glu Glu 
    1685                 1690                 1695             


Glu Glu  Leu Gln Ser Gln Gln  Leu Leu Pro Gln Gln  Leu Pro Glu 
    1700                 1705                 1710             


Cys Lys  Val Asp Ser Glu Thr  Asn Ile Glu Ala Ser  Lys Leu Pro 
    1715                 1720                 1725             


Thr Ser  Glu Pro Glu Ala Asp  Ala Glu Ile Glu Pro  Lys Glu Ser 
    1730                 1735                 1740             


Asn Gly  Thr Lys Leu Glu Glu  Pro Ile Asn Glu Glu  Thr Pro Ser 
    1745                 1750                 1755             


Gln Asp  Glu Glu Glu Gly Val  Ser Asp Val Glu Ser  Glu Arg Ser 
    1760                 1765                 1770             


Gln Glu  Gln Pro Asp Lys Thr  Val Asp Ile Ser Asp  Leu Ala Thr 
    1775                 1780                 1785             


Lys Leu  Leu Asp Ser Trp Lys  Asp Leu Lys Glu Val  Tyr Arg Ile 
    1790                 1795                 1800             


Pro Lys  Lys Ser Gln Thr Glu  Lys Glu Asn Thr Thr  Thr Glu Arg 
    1805                 1810                 1815             


Gly Arg  Asp Ala Val Gly Phe  Arg Asp Gln Thr Pro  Ala Pro Lys 
    1820                 1825                 1830             


Thr Pro  Asn Arg Ser Arg Glu  Arg Asp Pro Asp Lys  Gln Thr Gln 
    1835                 1840                 1845             


Asn Lys  Glu Lys Arg Lys Arg  Arg Ser Ser Leu Ser  Pro Pro Ser 
    1850                 1855                 1860             


Ser Ala  Tyr Glu Arg Gly Thr  Lys Arg Pro Asp Asp  Arg Tyr Asp 
    1865                 1870                 1875             


Thr Pro  Thr Ser Lys Lys Lys  Val Arg Ile Lys Asp  Arg Asn Lys 
    1880                 1885                 1890             


Leu Ser  Thr Glu Glu Arg Arg  Lys Leu Phe Glu Gln  Glu Val Ala 
    1895                 1900                 1905             


Gln Arg  Glu Ala Gln Lys Gln  Gln Gln Gln Met Gln  Asn Leu Gly 
    1910                 1915                 1920             


Met Thr  Ser Pro Leu Pro Tyr  Asp Ser Leu Gly Tyr  Asn Ala Pro 
    1925                 1930                 1935             


His His  Pro Phe Ala Gly Tyr  Pro Pro Gly Tyr Pro  Met Gln Ala 
    1940                 1945                 1950             


Tyr Val  Asp Pro Ser Asn Pro  Asn Ala Gly Lys Val  Leu Leu Pro 
    1955                 1960                 1965             


Thr Pro  Ser Met Asp Pro Val  Cys Ser Pro Ala Pro  Tyr Asp His 
    1970                 1975                 1980             


Ala Gln  Pro Leu Val Gly His  Ser Thr Glu Pro Leu  Ser Ala Pro 
    1985                 1990                 1995             


Pro Pro  Val Pro Val Val Pro  His Val Ala Ala Pro  Val Glu Val 
    2000                 2005                 2010             


Ser Ser  Ser Gln Tyr Val Ala  Gln Ser Asp Gly Val  Val His Gln 
    2015                 2020                 2025             


Asp Ser  Ser Val Ala Val Leu  Pro Val Pro Ala Pro  Gly Pro Val 
    2030                 2035                 2040             


Gln Gly  Gln Asn Tyr Ser Val  Trp Asp Ser Asn Gln  Gln Ser Val 
    2045                 2050                 2055             


Ser Val  Gln Gln Gln Tyr Ser  Pro Ala Gln Ser Gln  Ala Thr Ile 
    2060                 2065                 2070             


Tyr Tyr  Gln Gly Gln Thr Cys  Pro Thr Val Tyr Gly  Val Thr Ser 
    2075                 2080                 2085             


Pro Tyr  Ser Gln Thr Thr Pro  Pro Ile Val Gln Ser  Tyr Ala Gln 
    2090                 2095                 2100             


Pro Ser  Leu Gln Tyr Ile Gln  Gly Gln Gln Ile Phe  Thr Ala His 
    2105                 2110                 2115             


Pro Gln  Gly Val Val Val Gln  Pro Ala Ala Ala Val  Thr Thr Ile 
    2120                 2125                 2130             


Val Ala  Pro Gly Gln Pro Gln  Pro Leu Gln Pro Ser  Glu Met Val 
    2135                 2140                 2145             


Val Thr  Asn Asn Leu Leu Asp  Leu Pro Pro Pro Ser  Pro Pro Lys 
    2150                 2155                 2160             


Pro Lys  Thr Ile Val Leu Pro  Pro Asn Trp Lys Thr  Ala Arg Asp 
    2165                 2170                 2175             


Pro Glu  Gly Lys Ile Tyr Tyr  Tyr His Val Ile Thr  Arg Gln Thr 
    2180                 2185                 2190             


Gln Trp  Asp Pro Pro Thr Trp  Glu Ser Pro Gly Asp  Asp Ala Ser 
    2195                 2200                 2205             


Leu Glu  His Glu Ala Glu Met  Asp Leu Gly Thr Pro  Thr Tyr Asp 
    2210                 2215                 2220             


Glu Asn  Pro Met Lys Ala Ser  Lys Lys Pro Lys Thr  Ala Glu Ala 
    2225                 2230                 2235             


Asp Thr  Ser Ser Glu Leu Ala  Lys Lys Ser Lys Glu  Val Phe Arg 
    2240                 2245                 2250             


Lys Glu  Met Ser Gln Phe Ile  Val Gln Cys Leu Asn  Pro Tyr Arg 
    2255                 2260                 2265             


Lys Pro  Asp Cys Lys Val Gly  Arg Ile Thr Thr Thr  Glu Asp Phe 
    2270                 2275                 2280             


Lys His  Leu Ala Arg Lys Leu  Thr His Gly Val Met  Asn Lys Glu 
    2285                 2290                 2295             


Leu Lys  Tyr Cys Lys Asn Pro  Glu Asp Leu Glu Cys  Asn Glu Asn 
    2300                 2305                 2310             


Val Lys  His Lys Thr Lys Glu  Tyr Ile Lys Lys Tyr  Met Gln Lys 
    2315                 2320                 2325             


Phe Gly  Ala Val Tyr Lys Pro  Lys Glu Asp Thr Glu  Leu Glu 
    2330                 2335                 2340         


<210>  9319
<211>  8053
<212>  DNA
<213>  Homosapiens

<400>  9319
gggcgagcgc ctccgtcccc ggatgtgagc tccggctgcc cgcggtcccg agccagcggc     60

ggcgcgggcg gcggcggcgg gcaccgggca ccgcggcggg cgggcagacg ggcgggcatg    120

gggggagcgc cgagcggccc cggcggccgg gccggcatca ccgcggcgtc tctccgctag    180

aggaggggac aagccagttc tcctttgcag caaaaaatta catgtatata ttattaagat    240

aatatataca ttggatttta tttttttaaa aagtttattt tgctccattt ttgaaaaaga    300

gagagcttgg gtggcgagcg gttttttttt taaatcaatt atccttattt tctgttattt    360

gtccccgtcc ctccccaccc ccctgctgaa gcgagaataa gggcagggac cgcggctcct    420

acctcttggt gatccccttc cccattccgc ccccgcctca acgcccagca cagtgccctg    480

cacacagtag tcgctcaata aatgttcgtg gatgatgatg atgatgatga tgaaaaaaat    540

gcagcatcaa cggcagcagc aagcggacca cgcgaacgag gcaaactatg caagaggcac    600

cagacttcct ctttctggtg aaggaccaac ttctcagccg aatagctcca agcaaactgt    660

cctgtcttgg caagctgcaa tcgatgctgc tagacaggcc aaggctgccc aaactatgag    720

cacctctgca cccccacctg taggatctct ctcccaaaga aaacgtcagc aatacgccaa    780

gagcaaaaaa cagggtaact cgtccaacag ccgacctgcc cgcgcccttt tctgtttatc    840

actcaataac cccatccgaa gagcctgcat tagtatagtg gaatggaaac catttgacat    900

atttatatta ttggctattt ttgccaattg tgtggcctta gctatttaca tcccattccc    960

tgaagatgat tctaattcaa caaatcataa cttggaaaaa gtagaatatg ccttcctgat   1020

tatttttaca gtcgagacat ttttgaagat tatagcgtat ggattattgc tacatcctaa   1080

tgcttatgtt aggaatggat ggaatttact ggattttgtt atagtaatag taggattgtt   1140

tagtgtaatt ttggaacaat taaccaaaga aacagaaggc gggaaccact caagcggcaa   1200

atctggaggc tttgatgtca aagccctccg tgcctttcga gtgttgcgac cacttcgact   1260

agtgtcagga gtgcccagtt tacaagttgt cctgaactcc attataaaag ccatggttcc   1320

cctccttcac atagcccttt tggtattatt tgtaatcata atctatgcta ttataggatt   1380

ggaacttttt attggaaaaa tgcacaaaac atgttttttt gctgactcag atatcgtagc   1440

tgaagaggac ccagctccat gtgcgttctc agggaatgga cgccagtgta ctgccaatgg   1500

cacggaatgt aggagtggct gggttggccc gaacggaggc atcaccaact ttgataactt   1560

tgcctttgcc atgcttactg tgtttcagtg catcaccatg gagggctgga cagatgtgct   1620

ctactggatg aatgatgcta tgggatttga attgccctgg gtgtattttg tcagtctcgt   1680

catctttggg tcatttttcg tactaaatct tgtacttggt gtattgagcg gagaattctc   1740

aaaggaaaga gagaaggcaa aagcacgggg agatttccag aagctccggg agaagcagca   1800

gctggaggag gatctaaagg gctacttgga ttggatcacc caagctgagg acatcgatcc   1860

ggagaatgag gaagaaggag gagaggaagg caaacgaaat actagcatgc ccaccagcga   1920

gactgagtct gtgaacacag agaacgtcag cggtgaaggc gagaaccgag gctgctgtgg   1980

aagtctctgt caagccatct caaaatccaa actcagccga cgctggcgtc gctggaaccg   2040

attcaatcgc agaagatgta gggccgccgt gaagtctgtc acgttttact ggctggttat   2100

cgtcctggtg tttctgaaca ccttaaccat ttcctctgag cactacaatc agccagattg   2160

gttgacacag attcaagata ttgccaacaa agtcctcttg gctctgttca cctgcgagat   2220

gctggtaaaa atgtacagct tgggcctcca agcatatttc gtctctcttt tcaaccggtt   2280

tgattgcttc gtggtgtgtg gtggaatcac tgagacgatc ttggtggaac tggaaatcat   2340

gtctcccctg gggatctctg tgtttcggtg tgtgcgcctc ttaagaatct tcaaagtgac   2400

caggcactgg acttccctga gcaacttagt ggcatcctta ttaaactcca tgaagtccat   2460

cgcttcgctg ttgcttctgc tttttctctt cattatcatc ttttccttgc ttgggatgca   2520

gctgtttggc ggcaagttta attttgatga aacgcaaacc aagcggagca cctttgacaa   2580

tttccctcaa gcacttctca cagtgttcca gatcctgaca ggcgaagact ggaatgctgt   2640

gatgtacgat ggcatcatgg cttacggggg cccatcctct tcaggaatga tcgtctgcat   2700

ctacttcatc atcctcttca tttgtggtaa ctatattcta ctgaatgtct tcttggccat   2760

cgctgtagac aatttggctg atgctgaaag tctgaacact gctcagaaag aagaagcgga   2820

agaaaaggag aggaaaaaga ttgccagaaa agagagccta gaaaataaaa agaacaacaa   2880

accagaagtc aaccagatag ccaacagtga caacaaggtt acaattgatg actatagaga   2940

agaggatgaa gacaaggacc cctatccgcc ttgcgatgtg ccagtagggg aagaggaaga   3000

ggaagaggag gaggatgaac ctgaggttcc tgccggaccc cgtcctcgaa ggatctcgga   3060

gttgaacatg aaggaaaaaa ttgcccccat ccctgaaggg agcgctttct tcattcttag   3120

caagaccaac ccgatccgcg taggctgcca caagctcatc aaccaccaca tcttcaccaa   3180

cctcatcctt gtcttcatca tgctgagcag cgctgccctg gccgcagagg accccatccg   3240

cagccactcc ttccggaaca cgatactggg ttactttgac tatgccttca cagccatctt   3300

tactgttgag atcctgttga agatgacaac ttttggagct ttcctccaca aaggggcctt   3360

ctgcaggaac tacttcaatt tgctggatat gctggtggtt ggggtgtctc tggtgtcatt   3420

tgggattcaa tccagtgcca tctccgttgt gaagattctg agggtcttaa gggtcctgcg   3480

tcccctcagg gccatcaaca gagcaaaagg acttaagcac gtggtccagt gcgtcttcgt   3540

ggccatccgg accatcggca acatcatgat cgtcaccacc ctcctgcagt tcatgtttgc   3600

ctgtatcggg gtccagttgt tcaaggggaa gttctatcgc tgtacggatg aagccaaaag   3660

taaccctgaa gaatgcaggg gacttttcat cctctacaag gatggggatg ttgacagtcc   3720

tgtggtccgt gaacggatct ggcaaaacag tgatttcaac ttcgacaacg tcctctctgc   3780

tatgatggcg ctcttcacag tctccacgtt tgagggctgg cctgcgttgc tgtataaagc   3840

catcgactcg aatggagaga acatcggccc aatctacaac caccgcgtgg agatctccat   3900

cttcttcatc atctacatca tcattgtagc tttcttcatg atgaacatct ttgtgggctt   3960

tgtcatcgtt acatttcagg aacaaggaga aaaagagtat aagaactgtg agctggacaa   4020

aaatcagcgt cagtgtgttg aatacgcctt gaaagcacgt cccttgcgga gatacatccc   4080

caaaaacccc taccagtaca agttctggta cgtggtgaac tcttcgcctt tcgaatacat   4140

gatgtttgtc ctcatcatgc tcaacacact ctgcttggcc atgcagcact acgagcagtc   4200

caagatgttc aatgatgcca tggacattct gaacatggtc ttcaccgggg tgttcaccgt   4260

cgagatggtt ttgaaagtca tcgcatttaa gcctaagggg tattttagtg acgcctggaa   4320

cacgtttgac tccctcatcg taatcggcag cattatagac gtggccctca gcgaagcaga   4380

cccaactgaa agtgaaaatg tccctgtccc aactgctaca cctgggaact ctgaagagag   4440

caatagaatc tccatcacct ttttccgtct tttccgagtg atgcgattgg tgaagcttct   4500

cagcaggggg gaaggcatcc ggacattgct gtggactttt attaagtcct ttcaggcgct   4560

cccgtatgtg gccctcctca tagccatgct gttcttcatc tatgcggtca ttggcatgca   4620

gatgtttggg aaagttgcca tgagagataa caaccagatc aataggaaca ataacttcca   4680

gacgtttccc caggcggtgc tgctgctctt caggtgtgca acaggtgagg cctggcagga   4740

gatcatgctg gcctgtctcc cagggaagct ctgtgaccct gagtcagatt acaaccccgg   4800

ggaggagtat acatgtggga gcaactttgc cattgtctat ttcatcagtt tttacatgct   4860

ctgtgcattt ctgatcatca atctgtttgt ggctgtcatc atggataatt tcgactatct   4920

gacccgggac tggtctattt tggggcctca ccatttagat gaattcaaaa gaatatggtc   4980

agaatatgac cctgaggcaa agggaaggat aaaacacctt gatgtggtca ctctgcttcg   5040

acgcatccag cctcccctgg ggtttgggaa gttatgtcca cacagggtag cgtgcaagag   5100

attagttgcc atgaacatgc ctctcaacag tgacgggaca gtcatgttta atgcaaccct   5160

gtttgctttg gttcgaacgg ctcttaagat caagaccgaa gggaacctgg agcaagctaa   5220

tgaagaactt cgggctgtga taaagaaaat ttggaagaaa accagcatga aattacttga   5280

ccaagttgtc cctccagctg gtgatgatga ggtaaccgtg gggaagttct atgccacttt   5340

cctgatacag gactacttta ggaaattcaa gaaacggaaa gaacaaggac tggtgggaaa   5400

gtaccctgcg aagaacacca caattgccct acaggcggga ttaaggacac tgcatgacat   5460

tgggccagaa atccggcgtg ctatatcgtg tgatttgcaa gatgacgagc ctgaggaaac   5520

aaaacgagaa gaagaagatg atgtgttcaa aagaaatggt gccctgcttg gaaaccatgt   5580

caatcatgtt aatagtgata ggagagattc ccttcagcag accaatacca cccaccgtcc   5640

cctgcatgtc caaaggcctt caattccacc tgcaagtgat actgagaaac cgctgtttcc   5700

tccagcagga aattcggtgt gtcataacca tcataaccat aattccatag gaaagcaagt   5760

tcccacctca acaaatgcca atctcaataa tgccaatatg tccaaagctg cccatggaaa   5820

gcggcccagc attgggaacc ttgagcatgt gtctgaaaat gggcatcatt cttcccacaa   5880

gcatgaccgg gagcctcaga gaaggtccag tgtgaaaaga acccgctatt atgaaactta   5940

cattaggtcc gactcaggag atgaacagct cccaactatt tgccgggaag acccagagat   6000

acatggctat ttcagggacc cccactgctt gggggagcag gagtatttca gtagtgagga   6060

atgctacgag gatgacagct cgcccacctg gagcaggcaa aactatggct actacagcag   6120

atacccaggc agaaacatcg actctgagag gccccgaggc taccatcatc cccaaggatt   6180

cttggaggac gatgactcgc ccgtttgcta tgattcacgg agatctccaa ggagacgcct   6240

actacctccc accccagcat cccaccggag atcctccttc aactttgagt gcctgcgccg   6300

gcagagcagc caggaagagg tcccgtcgtc tcccatcttc ccccatcgca cggccctgcc   6360

tctgcatcta atgcagcaac agatcatggc agttgccggc ctagattcaa gtaaagccca   6420

gaagtactca ccgagtcact cgacccggtc gtgggccacc cctccagcaa cccctcccta   6480

ccgggactgg acaccgtgct acacccccct gatccaagtg gagcagtcag aggccctgga   6540

ccaggtgaac ggcagcctgc cgtccctgca ccgcagctcc tggtacacag acgagcccga   6600

catctcctac cggactttca caccagccag cctgactgtc cccagcagct tccggaacaa   6660

aaacagcgac aagcagagga gtgcggacag cttggtggag gcagtcctga tatccgaagg   6720

cttgggacgc tatgcaaggg acccaaaatt tgtgtcagca acaaaacacg aaatcgctga   6780

tgcctgtgac ctcaccatcg acgagatgga gagtgcagcc agcaccctgc ttaatgggaa   6840

cgtgcgtccc cgagccaacg gggatgtggg ccccctctca caccggcagg actatgagct   6900

acaggacttt ggtcctggct acagcgacga agagccagac cctgggaggg atgaggagga   6960

cctggcggat gaaatgatat gcatcaccac cttgtagccc ccagcgaggg gcagactggc   7020

tctggcctca ggtggggcgc aggagagcca ggggaaaagt gcctcatagt taggaaagtt   7080

taggcactag ttgggagtaa tattcaatta attagacttt tgtataagag atgtcatgcc   7140

tcaagaaagc cataaacctg gtaggaacag gtcccaagcg gttgagcctg gcagagtacc   7200

atgcgctcgg ccccagctgc aggaaacagc aggccccgcc ctctcacaga ggatgggtga   7260

ggaggccaga cctgccctgc cccattgtcc agatgggcac tgctgtggag tctgcttctc   7320

ccatgtacca gggcaccagg cccacccaac tgaaggcatg gcggcggggt gcaggggaaa   7380

gttaaaggtg atgacgatca tcacacctgt gtcgttacct cagccatcgg tctagcatat   7440

cagtcactgg gcccaacata tccattttta aaccctttcc cccaaataca ctgcgtcctg   7500

gttcctgttt agctgttctg aaatacggtg tgtaagtaag tcagaaccca gctaccagtg   7560

attattgcga gggcaatggg acctcataaa taaggttttc tgtgatgtga cgccagttta   7620

cataagagaa tatcactccg atggtcggtt tctgactgtc acgctaaggg caactgtaaa   7680

ctggaataat aatgcactcg caaccaggta aacttagata cactagtttg tttaaaatta   7740

tagatttact gtacatgact tgtaatatac tataatttgt atttgtaaag agatggtcta   7800

tattttgtaa ttactgtatt gtatttgaac tgcagcaata tccatgggtc ctaataattg   7860

tagttcccca ctaaaatcta gaaattatta gtatttttac tcgggctatc cagaagtaga   7920

agaaatagag ccaattctca tttattcagc gaaaatcctc tggggttaaa attttaagtt   7980

tgaaagaact tgacactaca gaaatttttc taaaatattt tgagtcacta taaacctatc   8040

atctttccac aag                                                      8053


<210>  9320
<211>  2161
<212>  PRT
<213>  Homosapiens

<400>  9320

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365             


Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                485                 490                 495     


Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
            500                 505                 510         


Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu 
        515                 520                 525             


Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His 
    530                 535                 540                 


Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys 
545                 550                 555                 560 


Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser 
                565                 570                 575     


Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
            580                 585                 590         


Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu 
        595                 600                 605             


Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
    610                 615                 620                 


Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu Ser Asn Leu Val 
625                 630                 635                 640 


Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu 
                645                 650                 655     


Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
            660                 665                 670         


Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe 
        675                 680                 685             


Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly 
    690                 695                 700                 


Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
705                 710                 715                 720 


Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                725                 730                 735     


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            740                 745                 750         


Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu 
        755                 760                 765             


Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
    770                 775                 780                 


Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
785                 790                 795                 800 


Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                805                 810                 815     


Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
        835                 840                 845             


Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
    850                 855                 860                 


Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His 
865                 870                 875                 880 


Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile 
                885                 890                 895     


Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
            900                 905                 910         


Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala 
        915                 920                 925             


Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe 
    930                 935                 940                 


Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
945                 950                 955                 960 


Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                965                 970                 975     


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            980                 985                 990         


Arg Ala Ile Asn Arg Ala Lys Gly  Leu Lys His Val Val  Gln Cys Val 
        995                 1000                 1005             


Phe Val  Ala Ile Arg Thr Ile  Gly Asn Ile Met Ile  Val Thr Thr 
    1010                 1015                 1020             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1025                 1030                 1035             


Gly Lys  Phe Tyr Arg Cys Thr  Asp Glu Ala Lys Ser  Asn Pro Glu 
    1040                 1045                 1050             


Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys Asp Gly  Asp Val Asp 
    1055                 1060                 1065             


Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln Asn Ser  Asp Phe Asn 
    1070                 1075                 1080             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Thr Val Ser 
    1085                 1090                 1095             


Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ser 
    1100                 1105                 1110             


Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn His Arg  Val Glu Ile 
    1115                 1120                 1125             


Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile Val Ala  Phe Phe Met 
    1130                 1135                 1140             


Met Asn  Ile Phe Val Gly Phe  Val Ile Val Thr Phe  Gln Glu Gln 
    1145                 1150                 1155             


Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1160                 1165                 1170             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg Pro Leu  Arg Arg Tyr 
    1175                 1180                 1185             


Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe Trp Tyr  Val Val Asn 
    1190                 1195                 1200             


Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val Leu Ile  Met Leu Asn 
    1205                 1210                 1215             


Thr Leu  Cys Leu Ala Met Gln  His Tyr Glu Gln Ser  Lys Met Phe 
    1220                 1225                 1230             


Asn Asp  Ala Met Asp Ile Leu  Asn Met Val Phe Thr  Gly Val Phe 
    1235                 1240                 1245             


Thr Val  Glu Met Val Leu Lys  Val Ile Ala Phe Lys  Pro Lys Gly 
    1250                 1255                 1260             


Tyr Phe  Ser Asp Ala Trp Asn  Thr Phe Asp Ser Leu  Ile Val Ile 
    1265                 1270                 1275             


Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu Ala Asp  Pro Thr Glu 
    1280                 1285                 1290             


Ser Glu  Asn Val Pro Val Pro  Thr Ala Thr Pro Gly  Asn Ser Glu 
    1295                 1300                 1305             


Glu Ser  Asn Arg Ile Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val 
    1310                 1315                 1320             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr 
    1325                 1330                 1335             


Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val 
    1340                 1345                 1350             


Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1355                 1360                 1365             


Met Gln  Met Phe Gly Lys Val  Ala Met Arg Asp Asn  Asn Gln Ile 
    1370                 1375                 1380             


Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu 
    1385                 1390                 1395             


Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp Gln Glu  Ile Met Leu 
    1400                 1405                 1410             


Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro Glu Ser  Asp Tyr Asn 
    1415                 1420                 1425             


Pro Gly  Glu Glu Tyr Thr Cys  Gly Ser Asn Phe Ala  Ile Val Tyr 
    1430                 1435                 1440             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1445                 1450                 1455             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp 
    1460                 1465                 1470             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1475                 1480                 1485             


Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1490                 1495                 1500             


Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1505                 1510                 1515             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ala 
    1520                 1525                 1530             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr Val Met  Phe Asn Ala 
    1535                 1540                 1545             


Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu Lys Ile  Lys Thr Glu 
    1550                 1555                 1560             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Val Ile Lys 
    1565                 1570                 1575             


Lys Ile  Trp Lys Lys Thr Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1580                 1585                 1590             


Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val Gly Lys  Phe Tyr Ala 
    1595                 1600                 1605             


Thr Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1610                 1615                 1620             


Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala Lys Asn  Thr Thr Ile 
    1625                 1630                 1635             


Ala Leu  Gln Ala Gly Leu Arg  Thr Leu His Asp Ile  Gly Pro Glu 
    1640                 1645                 1650             


Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln Asp Asp  Glu Pro Glu 
    1655                 1660                 1665             


Glu Thr  Lys Arg Glu Glu Glu  Asp Asp Val Phe Lys  Arg Asn Gly 
    1670                 1675                 1680             


Ala Leu  Leu Gly Asn His Val  Asn His Val Asn Ser  Asp Arg Arg 
    1685                 1690                 1695             


Asp Ser  Leu Gln Gln Thr Asn  Thr Thr His Arg Pro  Leu His Val 
    1700                 1705                 1710             


Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp Thr Glu  Lys Pro Leu 
    1715                 1720                 1725             


Phe Pro  Pro Ala Gly Asn Ser  Val Cys His Asn His  His Asn His 
    1730                 1735                 1740             


Asn Ser  Ile Gly Lys Gln Val  Pro Thr Ser Thr Asn  Ala Asn Leu 
    1745                 1750                 1755             


Asn Asn  Ala Asn Met Ser Lys  Ala Ala His Gly Lys  Arg Pro Ser 
    1760                 1765                 1770             


Ile Gly  Asn Leu Glu His Val  Ser Glu Asn Gly His  His Ser Ser 
    1775                 1780                 1785             


His Lys  His Asp Arg Glu Pro  Gln Arg Arg Ser Ser  Val Lys Arg 
    1790                 1795                 1800             


Thr Arg  Tyr Tyr Glu Thr Tyr  Ile Arg Ser Asp Ser  Gly Asp Glu 
    1805                 1810                 1815             


Gln Leu  Pro Thr Ile Cys Arg  Glu Asp Pro Glu Ile  His Gly Tyr 
    1820                 1825                 1830             


Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln Glu Tyr  Phe Ser Ser 
    1835                 1840                 1845             


Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro Thr Trp  Ser Arg Gln 
    1850                 1855                 1860             


Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly Arg Asn  Ile Asp Ser 
    1865                 1870                 1875             


Glu Arg  Pro Arg Gly Tyr His  His Pro Gln Gly Phe  Leu Glu Asp 
    1880                 1885                 1890             


Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg Arg Ser  Pro Arg Arg 
    1895                 1900                 1905             


Arg Leu  Leu Pro Pro Thr Pro  Ala Ser His Arg Arg  Ser Ser Phe 
    1910                 1915                 1920             


Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser Gln Glu  Glu Val Pro 
    1925                 1930                 1935             


Ser Ser  Pro Ile Phe Pro His  Arg Thr Ala Leu Pro  Leu His Leu 
    1940                 1945                 1950             


Met Gln  Gln Gln Ile Met Ala  Val Ala Gly Leu Asp  Ser Ser Lys 
    1955                 1960                 1965             


Ala Gln  Lys Tyr Ser Pro Ser  His Ser Thr Arg Ser  Trp Ala Thr 
    1970                 1975                 1980             


Pro Pro  Ala Thr Pro Pro Tyr  Arg Asp Trp Thr Pro  Cys Tyr Thr 
    1985                 1990                 1995             


Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala Leu Asp  Gln Val Asn 
    2000                 2005                 2010             


Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser Trp Tyr  Thr Asp Glu 
    2015                 2020                 2025             


Pro Asp  Ile Ser Tyr Arg Thr  Phe Thr Pro Ala Ser  Leu Thr Val 
    2030                 2035                 2040             


Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp Lys Gln  Arg Ser Ala 
    2045                 2050                 2055             


Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser Glu Gly  Leu Gly Arg 
    2060                 2065                 2070             


Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala Thr Lys  His Glu Ile 
    2075                 2080                 2085             


Ala Asp  Ala Cys Asp Leu Thr  Ile Asp Glu Met Glu  Ser Ala Ala 
    2090                 2095                 2100             


Ser Thr  Leu Leu Asn Gly Asn  Val Arg Pro Arg Ala  Asn Gly Asp 
    2105                 2110                 2115             


Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr Glu Leu  Gln Asp Phe 
    2120                 2125                 2130             


Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp Pro Gly  Arg Asp Glu 
    2135                 2140                 2145             


Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile Thr Thr  Leu 
    2150                 2155                 2160     


<210>  9321
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9321
gggcgagcgc ctccgtcccc ggatgtgagc tccggctgcc cgcggtcccg agccagcggc     60

ggcgcgggcg gcggcggcgg gcaccgggca ccgcggcggg cgggcagacg ggcgggcatg    120

gggggagcgc cgagcggccc cggcggccgg gccggcatca ccgcggcgtc tctccgctag    180

aggaggggac aagccagttc tcctttgcag caaaaaatta catgtatata ttattaagat    240

aatatataca ttggatttta tttttttaaa aagtttattt tgctccattt ttgaaaaaga    300

gagagcttgg gtggcgagcg gttttttttt taaatcaatt atccttattt tctgttattt    360

gtccccgtcc ctccccaccc ccctgctgaa gcgagaataa gggcagggac cgcggctcct    420

acctcttggt gatccccttc cccattccgc ccccgcctca acgcccagca cagtgccctg    480

cacacagtag tcgctcaata aatgttcgtg gatgatgatg atgatgatga tgaaaaaaat    540

gcagcatcaa cggcagcagc aagcggacca cgcgaacgag gcaaactatg caagaggcac    600

cagacttcct ctttctggtg aaggaccaac ttctcagccg aatagctcca agcaaactgt    660

cctgtcttgg caagctgcaa tcgatgctgc tagacaggcc aaggctgccc aaactatgag    720

cacctctgca cccccacctg taggatctct ctcccaaaga aaacgtcagc aatacgccaa    780

gagcaaaaaa cagggtaact cgtccaacag ccgacctgcc cgcgcccttt tctgtttatc    840

actcaataac cccatccgaa gagcctgcat tagtatagtg gaatggaaac catttgacat    900

atttatatta ttggctattt ttgccaattg tgtggcctta gctatttaca tcccattccc    960

tgaagatgat tctaattcaa caaatcataa cttggaaaaa gtagaatatg ccttcctgat   1020

tatttttaca gtcgagacat ttttgaagat tatagcgtat ggattattgc tacatcctaa   1080

tgcttatgtt aggaatggat ggaatttact ggattttgtt atagtaatag taggattgtt   1140

tagtgtaatt ttggaacaat taaccaaaga aacagaaggc gggaaccact caagcggcaa   1200

atctggaggc tttgatgtca aagccctccg tgcctttcga gtgttgcgac cacttcgact   1260

agtgtcagga gtgcccagtt tacaagttgt cctgaactcc attataaaag ccatggttcc   1320

cctccttcac atagcccttt tggtattatt tgtaatcata atctatgcta ttataggatt   1380

ggaacttttt attggaaaaa tgcacaaaac atgttttttt gctgactcag atatcgtagc   1440

tgaagaggac ccagctccat gtgcgttctc agggaatgga cgccagtgta ctgccaatgg   1500

cacggaatgt aggagtggct gggttggccc gaacggaggc atcaccaact ttgataactt   1560

tgcctttgcc atgcttactg tgtttcagtg catcaccatg gagggctgga cagatgtgct   1620

ctactggatg aatgatgcta tgggatttga attgccctgg gtgtattttg tcagtctcgt   1680

catctttggg tcatttttcg tactaaatct tgtacttggt gtattgagcg gagaattctc   1740

aaaggaaaga gagaaggcaa aagcacgggg agatttccag aagctccggg agaagcagca   1800

gctggaggag gatctaaagg gctacttgga ttggatcacc caagctgagg acatcgatcc   1860

ggagaatgag gaagaaggag gagaggaagg caaacgaaat actagcatgc ccaccagcga   1920

gactgagtct gtgaacacag agaacgtcag cggtgaaggc gagaaccgag gctgctgtgg   1980

aagtctctgt caagccatct caaaatccaa actcagccga cgctggcgtc gctggaaccg   2040

attcaatcgc agaagatgta gggccgccgt gaagtctgtc acgttttact ggctggttat   2100

cgtcctggtg tttctgaaca ccttaaccat ttcctctgag cactacaatc agccagattg   2160

gttgacacag attcaagata ttgccaacaa agtcctcttg gctctgttca cctgcgagat   2220

gctggtaaaa atgtacagct tgggcctcca agcatatttc gtctctcttt tcaaccggtt   2280

tgattgcttc gtggtgtgtg gtggaatcac tgagacgatc ttggtggaac tggaaatcat   2340

gtctcccctg gggatctctg tgtttcggtg tgtgcgcctc ttaagaatct tcaaagtgac   2400

caggcactgg acttccctga gcaacttagt ggcatcctta ttaaactcca tgaagtccat   2460

cgcttcgctg ttgcttctgc tttttctctt cattatcatc ttttccttgc ttgggatgca   2520

gctgtttggc ggcaagttta attttgatga aacgcaaacc aagcggagca cctttgacaa   2580

tttccctcaa gcacttctca cagtgttcca gatcctgaca ggcgaagact ggaatgctgt   2640

gatgtacgat ggcatcatgg cttacggggg cccatcctct tcaggaatga tcgtctgcat   2700

ctacttcatc atcctcttca tttgtggtaa ctatattcta ctgaatgtct tcttggccat   2760

cgctgtagac aatttggctg atgctgaaag tctgaacact gctcagaaag aagaagcgga   2820

agaaaaggag aggaaaaaga ttgccagaaa agagagccta gaaaataaaa agaacaacaa   2880

accagaagtc aaccagatag ccaacagtga caacaaggtt acaattgatg actatagaga   2940

agaggatgaa gacaaggacc cctatccgcc ttgcgatgtg ccagtagggg aagaggaaga   3000

ggaagaggag gaggatgaac ctgaggttcc tgccggaccc cgtcctcgaa ggatctcgga   3060

gttgaacatg aaggaaaaaa ttgcccccat ccctgaaggg agcgctttct tcattcttag   3120

caagaccaac ccgatccgcg taggctgcca caagctcatc aaccaccaca tcttcaccaa   3180

cctcatcctt gtcttcatca tgctgagcag cgctgccctg gccgcagagg accccatccg   3240

cagccactcc ttccggaaca cgatactggg ttactttgac tatgccttca cagccatctt   3300

tactgttgag atcctgttga agatgacaac ttttggagct ttcctccaca aaggggcctt   3360

ctgcaggaac tacttcaatt tgctggatat gctggtggtt ggggtgtctc tggtgtcatt   3420

tgggattcaa tccagtgcca tctccgttgt gaagattctg agggtcttaa gggtcctgcg   3480

tcccctcagg gccatcaaca gagcaaaagg acttaagcac gtggtccagt gcgtcttcgt   3540

ggccatccgg accatcggca acatcatgat cgtcaccacc ctcctgcagt tcatgtttgc   3600

ctgtatcggg gtccagttgt tcaaggggaa gttctatcgc tgtacggatg aagccaaaag   3660

taaccctgaa gaatgcaggg gacttttcat cctctacaag gatggggatg ttgacagtcc   3720

tgtggtccgt gaacggatct ggcaaaacag tgatttcaac ttcgacaacg tcctctctgc   3780

tatgatggcg ctcttcacag tctccacgtt tgagggctgg cctgcgttgc tgtataaagc   3840

catcgactcg aatggagaga acatcggccc aatctacaac caccgcgtgg agatctccat   3900

cttcttcatc atctacatca tcattgtagc tttcttcatg atgaacatct ttgtgggctt   3960

tgtcatcgtt acatttcagg aacaaggaga aaaagagtat aagaactgtg agctggacaa   4020

aaatcagcgt cagtgtgttg aatacgcctt gaaagcacgt cccttgcgga gatacatccc   4080

caaaaacccc taccagtaca agttctggta cgtggtgaac tcttcgcctt tcgaatacat   4140

gatgtttgtc ctcatcatgc tcaacacact ctgcttggcc atgcagcact acgagcagtc   4200

caagatgttc aatgatgcca tggacattct gaacatggtc ttcaccgggg tgttcaccgt   4260

cgagatggtt ttgaaagtca tcgcatttaa gcctaagggg tattttagtg acgcctggaa   4320

cacgtttgac tccctcatcg taatcggcag cattatagac gtggccctca gcgaagcaga   4380

cccaactgaa agtgaaaatg tccctgtccc aactgctaca cctgggaact ctgaagagag   4440

caatagaatc tccatcacct ttttccgtct tttccgagtg atgcgattgg tgaagcttct   4500

cagcaggggg gaaggcatcc ggacattgct gtggactttt attaagtcct ttcaggcgct   4560

cccgtatgtg gccctcctca tagccatgct gttcttcatc tatgcggtca ttggcatgca   4620

gatgtttggg aaagttgcca tgagagataa caaccagatc aataggaaca ataacttcca   4680

gacgtttccc caggcggtgc tgctgctctt caggtgtgca acaggtgagg cctggcagga   4740

gatcatgctg gcctgtctcc cagggaagct ctgtgaccct gagtcagatt acaaccccgg   4800

ggaggagtat acatgtggga gcaactttgc cattgtctat ttcatcagtt tttacatgct   4860

ctgtgcattt ctgatcatca atctgtttgt ggctgtcatc atggataatt tcgactatct   4920

gacccgggac tggtctattt tggggcctca ccatttagat gaattcaaaa gaatatggtc   4980

agaatatgac cctgaggcaa agggaaggat aaaacacctt gatgtggtca ctctgcttcg   5040

acgcatccag cctcccctgg ggtttgggaa gttatgtcca cacagggtag cgtgcaagag   5100

attagttgcc atgaacatgc ctctcaacag tgacgggaca gtcatgttta atgcaaccct   5160

gtttgctttg gttcgaacgg ctcttaagat caagaccgaa gggaacctgg agcaagctaa   5220

tgaagaactt cgggctgtga taaagaaaat ttggaagaaa accagcatga aattacttga   5280

ccaagttgtc cctccagctg gtgatgatga ggtaaccgtg gggaagttct atgccacttt   5340

cctgatacag gactacttta ggaaattcaa gaaacggaaa gaacaaggac tggtgggaaa   5400

gtaccctgcg aagaacacca caattgccct acaggcggga ttaaggacac tgcatgacat   5460

tgggccagaa atccggcgtg ctatatcgtg tgatttgcaa gatgacgagc ctgaggaaac   5520

aaaacgagaa gaagaagatg atgtgttcaa aagaaatggt gccctgcttg gaaaccatgt   5580

caatcatgtt aatagtgata ggagagattc ccttcagcag accaatacca cccaccgtcc   5640

cctgcatgtc caaaggcctt caattccacc tgcaagtgat actgagaaac cgctgtttcc   5700

tccagcagga aattcggtgt gtcataacca tcataaccat aattccatag gaaagcaagt   5760

tcccacctca acaaatgcca atctcaataa tgccaatatg tccaaagctg cccatggaaa   5820

gcggcccagc attgggaacc ttgagcatgt gtctgaaaat gggcatcatt cttcccacaa   5880

gcatgaccgg gagcctcaga gaaggtccag tgtgaaaaga acccgctatt atgaaactta   5940

cattaggtcc gactcaggag atgaacagct cccaactatt tgccgggaag acccagagat   6000

acatggctat ttcagggacc cccactgctt gggggagcag gagtatttca gtagtgagga   6060

atgctacgag gatgacagct cgcccacctg gagcaggcaa aactatggct actacagcag   6120

atacccaggc agaaacatcg actctgagag gccccgaggc taccatcatc cccaaggatt   6180

cttggaggac gatgactcgc ccgtttgcta tgattcacgg agatctccaa ggagacgcct   6240

actacctccc accccagcat cccaccggag atcctccttc aactttgagt gcctgcgccg   6300

gcagagcagc caggaagagg tcccgtcgtc tcccatcttc ccccatcgca cggccctgcc   6360

tctgcatcta atgcagcaac agatcatggc agttgccggc ctagattcaa gtaaagccca   6420

gaagtactca ccgagtcact cgacccggtc gtgggccacc cctccagcaa cccctcccta   6480

ccgggactgg acaccgtgct acacccccct gatccaagtg gagcagtcag aggccctgga   6540

ccaggtgaac ggcagcctgc cgtccctgca ccgcagctcc tggtacacag acgagcccga   6600

catctcctac cggactttca caccagccag cctgactgtc cccagcagct tccggaacaa   6660

aaacagcgac aagcagagga gtgcggacag cttggtggag gcagtcctga tatccgaagg   6720

cttgggacgc tatgcaaggg acccaaaatt tgtgtcagca acaaaacacg aaatcgctga   6780

tgcctgtgac ctcaccatcg acgagatgga gagtgcagcc agcaccctgc ttaatgggaa   6840

cgtgcgtccc cgagccaacg gggatgtggg ccccctctca caccggcagg actatgagct   6900

acaggacttt ggtcctggct acagcgacga agagccagac cctgggaggg atgaggagga   6960

cctggcggat gaaatgatat gcatcaccac cttgtagccc ccagcgaggg gcagactggc   7020

tctggcctca ggtggggcgc aggagagcca ggggaaaagt gcctcatagt taggaaagtt   7080

taggcactag ttgggagtaa tattcaatta attagacttt tgtataagag atgtcatgcc   7140

tcaagaaagc cataaacctg gtaggaacag gtcccaagcg gttgagcctg gcagagtacc   7200

atgcgctcgg ccccagctgc aggaaacagc aggccccgcc ctctcacaga ggatgggtga   7260

ggaggccaga cctgccctgc cccattgtcc agatgggcac tgctgtggag tctgcttctc   7320

ccatgtacca gggcaccagg cccacccaac tgaaggcatg gcggcggggt gcaggggaaa   7380

gttaaaggtg atgacgatca tcacacctgt gtcgttacct cagccatcgg tctagcatat   7440

cagtcactgg gcccaacata tccattttta aaccctttcc cccaaataca ctgcgtcctg   7500

gttcctgttt agctgttctg aaatacggtg tgtaagtaag tcagaaccca gctaccagtg   7560

attattgcga gggcaatggg acctcataaa taaggttttc tgtgatgtga cgccagttta   7620

cataagagaa tatcactccg atggtcggtt tctgactgtc acgctaaggg caactgtaaa   7680

ctggaataat aatgcactcg caaccaggta aacttagata cactagtttg tttaaaatta   7740

tagatttact gtacatgact tgtaatatac tataatttgt atttgtaaag agatggtcta   7800

tattttgtaa ttactgtatt gtatttgaac tgcagcaata tccatgggtc ctaataattg   7860

tagttcccca ctaaaatcta gaaattatta gtatttttac tcgggctatc cagaagtaga   7920

agaaatagag ccaattctca tttattcagc gaaaatcctc tggggttaaa attttaagtt   7980

tgaaagaact tgacactaca gaaatttttc taaaatattt tgagtcacta taaacctatc   8040

atctttccac aagatatacc agatgactat ttgcagtctt ttctttgggc aagagttcca   8100

tgattttgat actgtacctt tggatccacc atgggttgca actgtctttg gttttgtttg   8160

tttgacttga accaccctct ggtaagtaag ta                                 8192


<210>  9322
<211>  2161
<212>  PRT
<213>  Homosapiens

<400>  9322

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365             


Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                485                 490                 495     


Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
            500                 505                 510         


Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu 
        515                 520                 525             


Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His 
    530                 535                 540                 


Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys 
545                 550                 555                 560 


Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser 
                565                 570                 575     


Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
            580                 585                 590         


Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu 
        595                 600                 605             


Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
    610                 615                 620                 


Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu Ser Asn Leu Val 
625                 630                 635                 640 


Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu 
                645                 650                 655     


Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
            660                 665                 670         


Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe 
        675                 680                 685             


Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly 
    690                 695                 700                 


Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
705                 710                 715                 720 


Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                725                 730                 735     


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            740                 745                 750         


Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu 
        755                 760                 765             


Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
    770                 775                 780                 


Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
785                 790                 795                 800 


Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                805                 810                 815     


Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
        835                 840                 845             


Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
    850                 855                 860                 


Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His 
865                 870                 875                 880 


Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile 
                885                 890                 895     


Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
            900                 905                 910         


Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala 
        915                 920                 925             


Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe 
    930                 935                 940                 


Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
945                 950                 955                 960 


Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                965                 970                 975     


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            980                 985                 990         


Arg Ala Ile Asn Arg Ala Lys Gly  Leu Lys His Val Val  Gln Cys Val 
        995                 1000                 1005             


Phe Val  Ala Ile Arg Thr Ile  Gly Asn Ile Met Ile  Val Thr Thr 
    1010                 1015                 1020             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1025                 1030                 1035             


Gly Lys  Phe Tyr Arg Cys Thr  Asp Glu Ala Lys Ser  Asn Pro Glu 
    1040                 1045                 1050             


Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys Asp Gly  Asp Val Asp 
    1055                 1060                 1065             


Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln Asn Ser  Asp Phe Asn 
    1070                 1075                 1080             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Thr Val Ser 
    1085                 1090                 1095             


Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ser 
    1100                 1105                 1110             


Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn His Arg  Val Glu Ile 
    1115                 1120                 1125             


Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile Val Ala  Phe Phe Met 
    1130                 1135                 1140             


Met Asn  Ile Phe Val Gly Phe  Val Ile Val Thr Phe  Gln Glu Gln 
    1145                 1150                 1155             


Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1160                 1165                 1170             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg Pro Leu  Arg Arg Tyr 
    1175                 1180                 1185             


Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe Trp Tyr  Val Val Asn 
    1190                 1195                 1200             


Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val Leu Ile  Met Leu Asn 
    1205                 1210                 1215             


Thr Leu  Cys Leu Ala Met Gln  His Tyr Glu Gln Ser  Lys Met Phe 
    1220                 1225                 1230             


Asn Asp  Ala Met Asp Ile Leu  Asn Met Val Phe Thr  Gly Val Phe 
    1235                 1240                 1245             


Thr Val  Glu Met Val Leu Lys  Val Ile Ala Phe Lys  Pro Lys Gly 
    1250                 1255                 1260             


Tyr Phe  Ser Asp Ala Trp Asn  Thr Phe Asp Ser Leu  Ile Val Ile 
    1265                 1270                 1275             


Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu Ala Asp  Pro Thr Glu 
    1280                 1285                 1290             


Ser Glu  Asn Val Pro Val Pro  Thr Ala Thr Pro Gly  Asn Ser Glu 
    1295                 1300                 1305             


Glu Ser  Asn Arg Ile Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val 
    1310                 1315                 1320             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr 
    1325                 1330                 1335             


Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val 
    1340                 1345                 1350             


Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1355                 1360                 1365             


Met Gln  Met Phe Gly Lys Val  Ala Met Arg Asp Asn  Asn Gln Ile 
    1370                 1375                 1380             


Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu 
    1385                 1390                 1395             


Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp Gln Glu  Ile Met Leu 
    1400                 1405                 1410             


Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro Glu Ser  Asp Tyr Asn 
    1415                 1420                 1425             


Pro Gly  Glu Glu Tyr Thr Cys  Gly Ser Asn Phe Ala  Ile Val Tyr 
    1430                 1435                 1440             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1445                 1450                 1455             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp 
    1460                 1465                 1470             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1475                 1480                 1485             


Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1490                 1495                 1500             


Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1505                 1510                 1515             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ala 
    1520                 1525                 1530             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr Val Met  Phe Asn Ala 
    1535                 1540                 1545             


Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu Lys Ile  Lys Thr Glu 
    1550                 1555                 1560             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Val Ile Lys 
    1565                 1570                 1575             


Lys Ile  Trp Lys Lys Thr Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1580                 1585                 1590             


Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val Gly Lys  Phe Tyr Ala 
    1595                 1600                 1605             


Thr Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1610                 1615                 1620             


Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala Lys Asn  Thr Thr Ile 
    1625                 1630                 1635             


Ala Leu  Gln Ala Gly Leu Arg  Thr Leu His Asp Ile  Gly Pro Glu 
    1640                 1645                 1650             


Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln Asp Asp  Glu Pro Glu 
    1655                 1660                 1665             


Glu Thr  Lys Arg Glu Glu Glu  Asp Asp Val Phe Lys  Arg Asn Gly 
    1670                 1675                 1680             


Ala Leu  Leu Gly Asn His Val  Asn His Val Asn Ser  Asp Arg Arg 
    1685                 1690                 1695             


Asp Ser  Leu Gln Gln Thr Asn  Thr Thr His Arg Pro  Leu His Val 
    1700                 1705                 1710             


Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp Thr Glu  Lys Pro Leu 
    1715                 1720                 1725             


Phe Pro  Pro Ala Gly Asn Ser  Val Cys His Asn His  His Asn His 
    1730                 1735                 1740             


Asn Ser  Ile Gly Lys Gln Val  Pro Thr Ser Thr Asn  Ala Asn Leu 
    1745                 1750                 1755             


Asn Asn  Ala Asn Met Ser Lys  Ala Ala His Gly Lys  Arg Pro Ser 
    1760                 1765                 1770             


Ile Gly  Asn Leu Glu His Val  Ser Glu Asn Gly His  His Ser Ser 
    1775                 1780                 1785             


His Lys  His Asp Arg Glu Pro  Gln Arg Arg Ser Ser  Val Lys Arg 
    1790                 1795                 1800             


Thr Arg  Tyr Tyr Glu Thr Tyr  Ile Arg Ser Asp Ser  Gly Asp Glu 
    1805                 1810                 1815             


Gln Leu  Pro Thr Ile Cys Arg  Glu Asp Pro Glu Ile  His Gly Tyr 
    1820                 1825                 1830             


Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln Glu Tyr  Phe Ser Ser 
    1835                 1840                 1845             


Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro Thr Trp  Ser Arg Gln 
    1850                 1855                 1860             


Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly Arg Asn  Ile Asp Ser 
    1865                 1870                 1875             


Glu Arg  Pro Arg Gly Tyr His  His Pro Gln Gly Phe  Leu Glu Asp 
    1880                 1885                 1890             


Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg Arg Ser  Pro Arg Arg 
    1895                 1900                 1905             


Arg Leu  Leu Pro Pro Thr Pro  Ala Ser His Arg Arg  Ser Ser Phe 
    1910                 1915                 1920             


Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser Gln Glu  Glu Val Pro 
    1925                 1930                 1935             


Ser Ser  Pro Ile Phe Pro His  Arg Thr Ala Leu Pro  Leu His Leu 
    1940                 1945                 1950             


Met Gln  Gln Gln Ile Met Ala  Val Ala Gly Leu Asp  Ser Ser Lys 
    1955                 1960                 1965             


Ala Gln  Lys Tyr Ser Pro Ser  His Ser Thr Arg Ser  Trp Ala Thr 
    1970                 1975                 1980             


Pro Pro  Ala Thr Pro Pro Tyr  Arg Asp Trp Thr Pro  Cys Tyr Thr 
    1985                 1990                 1995             


Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala Leu Asp  Gln Val Asn 
    2000                 2005                 2010             


Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser Trp Tyr  Thr Asp Glu 
    2015                 2020                 2025             


Pro Asp  Ile Ser Tyr Arg Thr  Phe Thr Pro Ala Ser  Leu Thr Val 
    2030                 2035                 2040             


Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp Lys Gln  Arg Ser Ala 
    2045                 2050                 2055             


Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser Glu Gly  Leu Gly Arg 
    2060                 2065                 2070             


Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala Thr Lys  His Glu Ile 
    2075                 2080                 2085             


Ala Asp  Ala Cys Asp Leu Thr  Ile Asp Glu Met Glu  Ser Ala Ala 
    2090                 2095                 2100             


Ser Thr  Leu Leu Asn Gly Asn  Val Arg Pro Arg Ala  Asn Gly Asp 
    2105                 2110                 2115             


Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr Glu Leu  Gln Asp Phe 
    2120                 2125                 2130             


Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp Pro Gly  Arg Asp Glu 
    2135                 2140                 2145             


Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile Thr Thr  Leu 
    2150                 2155                 2160     


<210>  9323
<211>  7720
<212>  DNA
<213>  Homosapiens

<400>  9323
agaataaggg cagggaccgc ggctcctacc tcttggtgat ccccttcccc attccgcccc     60

cgcctcaacg cccagcacag tgccctgcac acagtagtcg ctcaataaat gttcgtggat    120

gatgatgatg atgatgatga aaaaaatgca gcatcaacgg cagcagcaag cggaccacgc    180

gaacgaggca aactatgcaa gaggcaccag acttcctctt tctggtgaag gaccaacttc    240

tcagccgaat agctccaagc aaactgtcct gtcttggcaa gctgcaatcg atgctgctag    300

acaggccaag gctgcccaaa ctatgagcac ctctgcaccc ccacctgtag gatctctctc    360

ccaaagaaaa cgtcagcaat acgccaagag caaaaaacag ggtaactcgt ccaacagccg    420

acctgcccgc gcccttttct gtttatcact caataacccc atccgaagag cctgcattag    480

tatagtggaa tggaaaccat ttgacatatt tatattattg gctatttttg ccaattgtgt    540

ggccttagct atttacatcc cattccctga agatgattct aattcaacaa atcataactt    600

ggaaaaagta gaatatgcct tcctgattat ttttacagtc gagacatttt tgaagattat    660

agcgtatgga ttattgctac atcctaatgc ttatgttagg aatggatgga atttactgga    720

ttttgttata gtaatagtag gattgtttag tgtaattttg gaacaattaa ccaaagaaac    780

agaaggcggg aaccactcaa gcggcaaatc tggaggcttt gatgtcaaag ccctccgtgc    840

ctttcgagtg ttgcgaccac ttcgactagt gtcaggagtg cccagtttac aagttgtcct    900

gaactccatt ataaaagcca tggttcccct ccttcacata gcccttttgg tattatttgt    960

aatcataatc tatgctatta taggattgga actttttatt ggaaaaatgc acaaaacatg   1020

tttttttgct gactcagata tcgtagctga agaggaccca gctccatgtg cgttctcagg   1080

gaatggacgc cagtgtactg ccaatggcac ggaatgtagg agtggctggg ttggcccgaa   1140

cggaggcatc accaactttg ataactttgc ctttgccatg cttactgtgt ttcagtgcat   1200

caccatggag ggctggacag atgtgctcta ctgggtaaat gatgcgatag gatgggaatg   1260

gccatgggtg tattttgtta gtctgatcat ccttggctca tttttcgtcc ttaacctggt   1320

tcttggtgtc cttagtggag aattctcaaa ggaaagagag aaggcaaaag cacggggaga   1380

tttccagaag ctccgggaga agcagcagct ggaggaggat ctaaagggct acttggattg   1440

gatcacccaa gctgaggaca tcgatccgga gaatgaggaa gaaggaggag aggaaggcaa   1500

acgaaatact agcatgccca ccagcgagac tgagtctgtg aacacagaga acgtcagcgg   1560

tgaaggcgag aaccgaggct gctgtggaag tctctggtgc tggtggagac ggagaggcgc   1620

ggccaaggcg gggccctctg ggtgtcggcg gtggggtcaa gccatctcaa aatccaaact   1680

cagccgacgc tggcgtcgct ggaaccgatt caatcgcaga agatgtaggg ccgccgtgaa   1740

gtctgtcacg ttttactggc tggttatcgt cctggtgttt ctgaacacct taaccatttc   1800

ctctgagcac tacaatcagc cagattggtt gacacagatt caagatattg ccaacaaagt   1860

cctcttggct ctgttcacct gcgagatgct ggtaaaaatg tacagcttgg gcctccaagc   1920

atatttcgtc tctcttttca accggtttga ttgcttcgtg gtgtgtggtg gaatcactga   1980

gacgatcttg gtggaactgg aaatcatgtc tcccctgggg atctctgtgt ttcggtgtgt   2040

gcgcctctta agaatcttca aagtgaccag gcactggact tccctgagca acttagtggc   2100

atccttatta aactccatga agtccatcgc ttcgctgttg cttctgcttt ttctcttcat   2160

tatcatcttt tccttgcttg ggatgcagct gtttggcggc aagtttaatt ttgatgaaac   2220

gcaaaccaag cggagcacct ttgacaattt ccctcaagca cttctcacag tgttccagat   2280

cctgacaggc gaagactgga atgctgtgat gtacgatggc atcatggctt acgggggccc   2340

atcctcttca ggaatgatcg tctgcatcta cttcatcatc ctcttcattt gtggtaacta   2400

tattctactg aatgtcttct tggccatcgc tgtagacaat ttggctgatg ctgaaagtct   2460

gaacactgct cagaaagaag aagcggaaga aaaggagagg aaaaagattg ccagaaaaga   2520

gagcctagaa aataaaaaga acaacaaacc agaagtcaac cagatagcca acagtgacaa   2580

caaggttaca attgatgact atagagaaga ggatgaagac aaggacccct atccgccttg   2640

cgatgtgcca gtaggggaag aggaagagga agaggaggag gatgaacctg aggttcctgc   2700

cggaccccgt cctcgaagga tctcggagtt gaacatgaag gaaaaaattg cccccatccc   2760

tgaagggagc gctttcttca ttcttagcaa gaccaacccg atccgcgtag gctgccacaa   2820

gctcatcaac caccacatct tcaccaacct catccttgtc ttcatcatgc tgagcagcgc   2880

tgccctggcc gcagaggacc ccatccgcag ccactccttc cggaacacga tactgggtta   2940

ctttgactat gccttcacag ccatctttac tgttgagatc ctgttgaaga tgacaacttt   3000

tggagctttc ctccacaaag gggccttctg caggaactac ttcaatttgc tggatatgct   3060

ggtggttggg gtgtctctgg tgtcatttgg gattcaatcc agtgccatct ccgttgtgaa   3120

gattctgagg gtcttaaggg tcctgcgtcc cctcagggcc atcaacagag caaaaggact   3180

taagcacgtg gtccagtgcg tcttcgtggc catccggacc atcggcaaca tcatgatcgt   3240

caccaccctc ctgcagttca tgtttgcctg tatcggggtc cagttgttca aggggaagtt   3300

ctatcgctgt acggatgaag ccaaaagtaa ccctgaagaa tgcaggggac ttttcatcct   3360

ctacaaggat ggggatgttg acagtcctgt ggtccgtgaa cggatctggc aaaacagtga   3420

tttcaacttc gacaacgtcc tctctgctat gatggcgctc ttcacagtct ccacgtttga   3480

gggctggcct gcgttgctgt ataaagccat cgactcgaat ggagagaaca tcggcccaat   3540

ctacaaccac cgcgtggaga tctccatctt cttcatcatc tacatcatca ttgtagcttt   3600

cttcatgatg aacatctttg tgggctttgt catcgttaca tttcaggaac aaggagaaaa   3660

agagtataag aactgtgagc tggacaaaaa tcagcgtcag tgtgttgaat acgccttgaa   3720

agcacgtccc ttgcggagat acatccccaa aaacccctac cagtacaagt tctggtacgt   3780

ggtgaactct tcgcctttcg aatacatgat gtttgtcctc atcatgctca acacactctg   3840

cttggccatg cagcactacg agcagtccaa gatgttcaat gatgccatgg acattctgaa   3900

catggtcttc accggggtgt tcaccgtcga gatggttttg aaagtcatcg catttaagcc   3960

taaggggtat tttagtgacg cctggaacac gtttgactcc ctcatcgtaa tcggcagcat   4020

tatagacgtg gccctcagcg aagcagaccc aactgaaagt gaaaatgtcc ctgtcccaac   4080

tgctacacct gggaactctg aagagagcaa tagaatctcc atcacctttt tccgtctttt   4140

ccgagtgatg cgattggtga agcttctcag caggggggaa ggcatccgga cattgctgtg   4200

gacttttatt aagtcctttc aggcgctccc gtatgtggcc ctcctcatag ccatgctgtt   4260

cttcatctat gcggtcattg gcatgcagat gtttgggaaa gttgccatga gagataacaa   4320

ccagatcaat aggaacaata acttccagac gtttccccag gcggtgctgc tgctcttcag   4380

gtgtgcaaca ggtgaggcct ggcaggagat catgctggcc tgtctcccag ggaagctctg   4440

tgaccctgag tcagattaca accccgggga ggagtataca tgtgggagca actttgccat   4500

tgtctatttc atcagttttt acatgctctg tgcatttctg atcatcaatc tgtttgtggc   4560

tgtcatcatg gataatttcg actatctgac ccgggactgg tctattttgg ggcctcacca   4620

tttagatgaa ttcaaaagaa tatggtcaga atatgaccct gaggcaaagg gaaggataaa   4680

acaccttgat gtggtcactc tgcttcgacg catccagcct cccctggggt ttgggaagtt   4740

atgtccacac agggtagcgt gcaagagatt agttgccatg aacatgcctc tcaacagtga   4800

cgggacagtc atgtttaatg caaccctgtt tgctttggtt cgaacggctc ttaagatcaa   4860

gaccgaaggg aacctggagc aagctaatga agaacttcgg gctgtgataa agaaaatttg   4920

gaagaaaacc agcatgaaat tacttgacca agttgtccct ccagctggtg atgatgaggt   4980

aaccgtgggg aagttctatg ccactttcct gatacaggac tactttagga aattcaagaa   5040

acggaaagaa caaggactgg tgggaaagta ccctgcgaag aacaccacaa ttgccctaca   5100

ggcgggatta aggacactgc atgacattgg gccagaaatc cggcgtgcta tatcgtgtga   5160

tttgcaagat gacgagcctg aggaaacaaa acgagaagaa gaagatgatg tgttcaaaag   5220

aaatggtgcc ctgcttggaa accatgtcaa tcatgttaat agtgatagga gagattccct   5280

tcagcagacc aataccaccc accgtcccct gcatgtccaa aggccttcaa ttccacctgc   5340

aagtgatact gagaaaccgc tgtttcctcc agcaggaaat tcggtgtgtc ataaccatca   5400

taaccataat tccataggaa agcaagttcc cacctcaaca aatgccaatc tcaataatgc   5460

caatatgtcc aaagctgccc atggaaagcg gcccagcatt gggaaccttg agcatgtgtc   5520

tgaaaatggg catcattctt cccacaagca tgaccgggag cctcagagaa ggtccagtgt   5580

gaaaagaacc cgctattatg aaacttacat taggtccgac tcaggagatg aacagctccc   5640

aactatttgc cgggaagacc cagagataca tggctatttc agggaccccc actgcttggg   5700

ggagcaggag tatttcagta gtgaggaatg ctacgaggat gacagctcgc ccacctggag   5760

caggcaaaac tatggctact acagcagata cccaggcaga aacatcgact ctgagaggcc   5820

ccgaggctac catcatcccc aaggattctt ggaggacgat gactcgcccg tttgctatga   5880

ttcacggaga tctccaagga gacgcctact acctcccacc ccagcatccc accggagatc   5940

ctccttcaac tttgagtgcc tgcgccggca gagcagccag gaagaggtcc cgtcgtctcc   6000

catcttcccc catcgcacgg ccctgcctct gcatctaatg cagcaacaga tcatggcagt   6060

tgccggccta gattcaagta aagcccagaa gtactcaccg agtcactcga cccggtcgtg   6120

ggccacccct ccagcaaccc ctccctaccg ggactggaca ccgtgctaca cccccctgat   6180

ccaagtggag cagtcagagg ccctggacca ggtgaacggc agcctgccgt ccctgcaccg   6240

cagctcctgg tacacagacg agcccgacat ctcctaccgg actttcacac cagccagcct   6300

gactgtcccc agcagcttcc ggaacaaaaa cagcgacaag cagaggagtg cggacagctt   6360

ggtggaggca gtcctgatat ccgaaggctt gggacgctat gcaagggacc caaaatttgt   6420

gtcagcaaca aaacacgaaa tcgctgatgc ctgtgacctc accatcgacg agatggagag   6480

tgcagccagc accctgctta atgggaacgt gcgtccccga gccaacgggg atgtgggccc   6540

cctctcacac cggcaggact atgagctaca ggactttggt cctggctaca gcgacgaaga   6600

gccagaccct gggagggatg aggaggacct ggcggatgaa atgatatgca tcaccacctt   6660

gtagccccca gcgaggggca gactggctct ggcctcaggt ggggcgcagg agagccaggg   6720

gaaaagtgcc tcatagttag gaaagtttag gcactagttg ggagtaatat tcaattaatt   6780

agacttttgt ataagagatg tcatgcctca agaaagccat aaacctggta ggaacaggtc   6840

ccaagcggtt gagcctggca gagtaccatg cgctcggccc cagctgcagg aaacagcagg   6900

ccccgccctc tcacagagga tgggtgagga ggccagacct gccctgcccc attgtccaga   6960

tgggcactgc tgtggagtct gcttctccca tgtaccaggg caccaggccc acccaactga   7020

aggcatggcg gcggggtgca ggggaaagtt aaaggtgatg acgatcatca cacctgtgtc   7080

gttacctcag ccatcggtct agcatatcag tcactgggcc caacatatcc atttttaaac   7140

cctttccccc aaatacactg cgtcctggtt cctgtttagc tgttctgaaa tacggtgtgt   7200

aagtaagtca gaacccagct accagtgatt attgcgaggg caatgggacc tcataaataa   7260

ggttttctgt gatgtgacgc cagtttacat aagagaatat cactccgatg gtcggtttct   7320

gactgtcacg ctaagggcaa ctgtaaactg gaataataat gcactcgcaa ccaggtaaac   7380

ttagatacac tagtttgttt aaaattatag atttactgta catgacttgt aatatactat   7440

aatttgtatt tgtaaagaga tggtctatat tttgtaatta ctgtattgta tttgaactgc   7500

agcaatatcc atgggtccta ataattgtag ttccccacta aaatctagaa attattagta   7560

tttttactcg ggctatccag aagtagaaga aatagagcca attctcattt attcagcgaa   7620

aatcctctgg ggttaaaatt ttaagtttga aagaacttga cactacagaa atttttctaa   7680

aatattttga gtcactataa acctatcatc tttccacaag                         7720


<210>  9324
<211>  2181
<212>  PRT
<213>  Homosapiens

<400>  9324

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365             


Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Trp Cys Trp Trp 
                485                 490                 495     


Arg Arg Arg Gly Ala Ala Lys Ala Gly Pro Ser Gly Cys Arg Arg Trp 
            500                 505                 510         


Gly Gln Ala Ile Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp 
        515                 520                 525             


Asn Arg Phe Asn Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr 
    530                 535                 540                 


Phe Tyr Trp Leu Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile 
545                 550                 555                 560 


Ser Ser Glu His Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp 
                565                 570                 575     


Ile Ala Asn Lys Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val 
            580                 585                 590         


Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn 
        595                 600                 605             


Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu 
    610                 615                 620                 


Val Glu Leu Glu Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys 
625                 630                 635                 640 


Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu 
                645                 650                 655     


Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser 
            660                 665                 670         


Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly 
        675                 680                 685             


Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys 
    690                 695                 700                 


Arg Ser Thr Phe Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln 
705                 710                 715                 720 


Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met 
                725                 730                 735     


Ala Tyr Gly Gly Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe 
            740                 745                 750         


Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu 
        755                 760                 765             


Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala 
    770                 775                 780                 


Gln Lys Glu Glu Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys 
785                 790                 795                 800 


Glu Ser Leu Glu Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile 
                805                 810                 815     


Ala Asn Ser Asp Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp 
            820                 825                 830         


Glu Asp Lys Asp Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg 
    850                 855                 860                 


Pro Arg Arg Ile Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile 
865                 870                 875                 880 


Pro Glu Gly Ser Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg 
                885                 890                 895     


Val Gly Cys His Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile 
            900                 905                 910         


Leu Val Phe Ile Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro 
        915                 920                 925             


Ile Arg Ser His Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr 
    930                 935                 940                 


Ala Phe Thr Ala Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr 
945                 950                 955                 960 


Phe Gly Ala Phe Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn 
                965                 970                 975     


Leu Leu Asp Met Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile 
            980                 985                 990         


Gln Ser Ser Ala Ile Ser Val Val  Lys Ile Leu Arg Val  Leu Arg Val 
        995                 1000                 1005             


Leu Arg  Pro Leu Arg Ala Ile  Asn Arg Ala Lys Gly  Leu Lys His 
    1010                 1015                 1020             


Val Val  Gln Cys Val Phe Val  Ala Ile Arg Thr Ile  Gly Asn Ile 
    1025                 1030                 1035             


Met Ile  Val Thr Thr Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly 
    1040                 1045                 1050             


Val Gln  Leu Phe Lys Gly Lys  Phe Tyr Arg Cys Thr  Asp Glu Ala 
    1055                 1060                 1065             


Lys Ser  Asn Pro Glu Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys 
    1070                 1075                 1080             


Asp Gly  Asp Val Asp Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln 
    1085                 1090                 1095             


Asn Ser  Asp Phe Asn Phe Asp  Asn Val Leu Ser Ala  Met Met Ala 
    1100                 1105                 1110             


Leu Phe  Thr Val Ser Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr 
    1115                 1120                 1125             


Lys Ala  Ile Asp Ser Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn 
    1130                 1135                 1140             


His Arg  Val Glu Ile Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile 
    1145                 1150                 1155             


Val Ala  Phe Phe Met Met Asn  Ile Phe Val Gly Phe  Val Ile Val 
    1160                 1165                 1170             


Thr Phe  Gln Glu Gln Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu 
    1175                 1180                 1185             


Asp Lys  Asn Gln Arg Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg 
    1190                 1195                 1200             


Pro Leu  Arg Arg Tyr Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe 
    1205                 1210                 1215             


Trp Tyr  Val Val Asn Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val 
    1220                 1225                 1230             


Leu Ile  Met Leu Asn Thr Leu  Cys Leu Ala Met Gln  His Tyr Glu 
    1235                 1240                 1245             


Gln Ser  Lys Met Phe Asn Asp  Ala Met Asp Ile Leu  Asn Met Val 
    1250                 1255                 1260             


Phe Thr  Gly Val Phe Thr Val  Glu Met Val Leu Lys  Val Ile Ala 
    1265                 1270                 1275             


Phe Lys  Pro Lys Gly Tyr Phe  Ser Asp Ala Trp Asn  Thr Phe Asp 
    1280                 1285                 1290             


Ser Leu  Ile Val Ile Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu 
    1295                 1300                 1305             


Ala Asp  Pro Thr Glu Ser Glu  Asn Val Pro Val Pro  Thr Ala Thr 
    1310                 1315                 1320             


Pro Gly  Asn Ser Glu Glu Ser  Asn Arg Ile Ser Ile  Thr Phe Phe 
    1325                 1330                 1335             


Arg Leu  Phe Arg Val Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly 
    1340                 1345                 1350             


Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln 
    1355                 1360                 1365             


Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile 
    1370                 1375                 1380             


Tyr Ala  Val Ile Gly Met Gln  Met Phe Gly Lys Val  Ala Met Arg 
    1385                 1390                 1395             


Asp Asn  Asn Gln Ile Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro 
    1400                 1405                 1410             


Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp 
    1415                 1420                 1425             


Gln Glu  Ile Met Leu Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro 
    1430                 1435                 1440             


Glu Ser  Asp Tyr Asn Pro Gly  Glu Glu Tyr Thr Cys  Gly Ser Asn 
    1445                 1450                 1455             


Phe Ala  Ile Val Tyr Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe 
    1460                 1465                 1470             


Leu Ile  Ile Asn Leu Phe Val  Ala Val Ile Met Asp  Asn Phe Asp 
    1475                 1480                 1485             


Tyr Leu  Thr Arg Asp Trp Ser  Ile Leu Gly Pro His  His Leu Asp 
    1490                 1495                 1500             


Glu Phe  Lys Arg Ile Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly 
    1505                 1510                 1515             


Arg Ile  Lys His Leu Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln 
    1520                 1525                 1530             


Pro Pro  Leu Gly Phe Gly Lys  Leu Cys Pro His Arg  Val Ala Cys 
    1535                 1540                 1545             


Lys Arg  Leu Val Ala Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr 
    1550                 1555                 1560             


Val Met  Phe Asn Ala Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu 
    1565                 1570                 1575             


Lys Ile  Lys Thr Glu Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu 
    1580                 1585                 1590             


Arg Ala  Val Ile Lys Lys Ile  Trp Lys Lys Thr Ser  Met Lys Leu 
    1595                 1600                 1605             


Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val 
    1610                 1615                 1620             


Gly Lys  Phe Tyr Ala Thr Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys 
    1625                 1630                 1635             


Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala 
    1640                 1645                 1650             


Lys Asn  Thr Thr Ile Ala Leu  Gln Ala Gly Leu Arg  Thr Leu His 
    1655                 1660                 1665             


Asp Ile  Gly Pro Glu Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln 
    1670                 1675                 1680             


Asp Asp  Glu Pro Glu Glu Thr  Lys Arg Glu Glu Glu  Asp Asp Val 
    1685                 1690                 1695             


Phe Lys  Arg Asn Gly Ala Leu  Leu Gly Asn His Val  Asn His Val 
    1700                 1705                 1710             


Asn Ser  Asp Arg Arg Asp Ser  Leu Gln Gln Thr Asn  Thr Thr His 
    1715                 1720                 1725             


Arg Pro  Leu His Val Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp 
    1730                 1735                 1740             


Thr Glu  Lys Pro Leu Phe Pro  Pro Ala Gly Asn Ser  Val Cys His 
    1745                 1750                 1755             


Asn His  His Asn His Asn Ser  Ile Gly Lys Gln Val  Pro Thr Ser 
    1760                 1765                 1770             


Thr Asn  Ala Asn Leu Asn Asn  Ala Asn Met Ser Lys  Ala Ala His 
    1775                 1780                 1785             


Gly Lys  Arg Pro Ser Ile Gly  Asn Leu Glu His Val  Ser Glu Asn 
    1790                 1795                 1800             


Gly His  His Ser Ser His Lys  His Asp Arg Glu Pro  Gln Arg Arg 
    1805                 1810                 1815             


Ser Ser  Val Lys Arg Thr Arg  Tyr Tyr Glu Thr Tyr  Ile Arg Ser 
    1820                 1825                 1830             


Asp Ser  Gly Asp Glu Gln Leu  Pro Thr Ile Cys Arg  Glu Asp Pro 
    1835                 1840                 1845             


Glu Ile  His Gly Tyr Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln 
    1850                 1855                 1860             


Glu Tyr  Phe Ser Ser Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro 
    1865                 1870                 1875             


Thr Trp  Ser Arg Gln Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly 
    1880                 1885                 1890             


Arg Asn  Ile Asp Ser Glu Arg  Pro Arg Gly Tyr His  His Pro Gln 
    1895                 1900                 1905             


Gly Phe  Leu Glu Asp Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg 
    1910                 1915                 1920             


Arg Ser  Pro Arg Arg Arg Leu  Leu Pro Pro Thr Pro  Ala Ser His 
    1925                 1930                 1935             


Arg Arg  Ser Ser Phe Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser 
    1940                 1945                 1950             


Gln Glu  Glu Val Pro Ser Ser  Pro Ile Phe Pro His  Arg Thr Ala 
    1955                 1960                 1965             


Leu Pro  Leu His Leu Met Gln  Gln Gln Ile Met Ala  Val Ala Gly 
    1970                 1975                 1980             


Leu Asp  Ser Ser Lys Ala Gln  Lys Tyr Ser Pro Ser  His Ser Thr 
    1985                 1990                 1995             


Arg Ser  Trp Ala Thr Pro Pro  Ala Thr Pro Pro Tyr  Arg Asp Trp 
    2000                 2005                 2010             


Thr Pro  Cys Tyr Thr Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala 
    2015                 2020                 2025             


Leu Asp  Gln Val Asn Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser 
    2030                 2035                 2040             


Trp Tyr  Thr Asp Glu Pro Asp  Ile Ser Tyr Arg Thr  Phe Thr Pro 
    2045                 2050                 2055             


Ala Ser  Leu Thr Val Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp 
    2060                 2065                 2070             


Lys Gln  Arg Ser Ala Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2075                 2080                 2085             


Glu Gly  Leu Gly Arg Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala 
    2090                 2095                 2100             


Thr Lys  His Glu Ile Ala Asp  Ala Cys Asp Leu Thr  Ile Asp Glu 
    2105                 2110                 2115             


Met Glu  Ser Ala Ala Ser Thr  Leu Leu Asn Gly Asn  Val Arg Pro 
    2120                 2125                 2130             


Arg Ala  Asn Gly Asp Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr 
    2135                 2140                 2145             


Glu Leu  Gln Asp Phe Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp 
    2150                 2155                 2160             


Pro Gly  Arg Asp Glu Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile 
    2165                 2170                 2175             


Thr Thr  Leu 
    2180     


<210>  9325
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9325
agaataaggg cagggaccgc ggctcctacc tcttggtgat ccccttcccc attccgcccc     60

cgcctcaacg cccagcacag tgccctgcac acagtagtcg ctcaataaat gttcgtggat    120

gatgatgatg atgatgatga aaaaaatgca gcatcaacgg cagcagcaag cggaccacgc    180

gaacgaggca aactatgcaa gaggcaccag acttcctctt tctggtgaag gaccaacttc    240

tcagccgaat agctccaagc aaactgtcct gtcttggcaa gctgcaatcg atgctgctag    300

acaggccaag gctgcccaaa ctatgagcac ctctgcaccc ccacctgtag gatctctctc    360

ccaaagaaaa cgtcagcaat acgccaagag caaaaaacag ggtaactcgt ccaacagccg    420

acctgcccgc gcccttttct gtttatcact caataacccc atccgaagag cctgcattag    480

tatagtggaa tggaaaccat ttgacatatt tatattattg gctatttttg ccaattgtgt    540

ggccttagct atttacatcc cattccctga agatgattct aattcaacaa atcataactt    600

ggaaaaagta gaatatgcct tcctgattat ttttacagtc gagacatttt tgaagattat    660

agcgtatgga ttattgctac atcctaatgc ttatgttagg aatggatgga atttactgga    720

ttttgttata gtaatagtag gattgtttag tgtaattttg gaacaattaa ccaaagaaac    780

agaaggcggg aaccactcaa gcggcaaatc tggaggcttt gatgtcaaag ccctccgtgc    840

ctttcgagtg ttgcgaccac ttcgactagt gtcaggagtg cccagtttac aagttgtcct    900

gaactccatt ataaaagcca tggttcccct ccttcacata gcccttttgg tattatttgt    960

aatcataatc tatgctatta taggattgga actttttatt ggaaaaatgc acaaaacatg   1020

tttttttgct gactcagata tcgtagctga agaggaccca gctccatgtg cgttctcagg   1080

gaatggacgc cagtgtactg ccaatggcac ggaatgtagg agtggctggg ttggcccgaa   1140

cggaggcatc accaactttg ataactttgc ctttgccatg cttactgtgt ttcagtgcat   1200

caccatggag ggctggacag atgtgctcta ctgggtaaat gatgcgatag gatgggaatg   1260

gccatgggtg tattttgtta gtctgatcat ccttggctca tttttcgtcc ttaacctggt   1320

tcttggtgtc cttagtggag aattctcaaa ggaaagagag aaggcaaaag cacggggaga   1380

tttccagaag ctccgggaga agcagcagct ggaggaggat ctaaagggct acttggattg   1440

gatcacccaa gctgaggaca tcgatccgga gaatgaggaa gaaggaggag aggaaggcaa   1500

acgaaatact agcatgccca ccagcgagac tgagtctgtg aacacagaga acgtcagcgg   1560

tgaaggcgag aaccgaggct gctgtggaag tctctggtgc tggtggagac ggagaggcgc   1620

ggccaaggcg gggccctctg ggtgtcggcg gtggggtcaa gccatctcaa aatccaaact   1680

cagccgacgc tggcgtcgct ggaaccgatt caatcgcaga agatgtaggg ccgccgtgaa   1740

gtctgtcacg ttttactggc tggttatcgt cctggtgttt ctgaacacct taaccatttc   1800

ctctgagcac tacaatcagc cagattggtt gacacagatt caagatattg ccaacaaagt   1860

cctcttggct ctgttcacct gcgagatgct ggtaaaaatg tacagcttgg gcctccaagc   1920

atatttcgtc tctcttttca accggtttga ttgcttcgtg gtgtgtggtg gaatcactga   1980

gacgatcttg gtggaactgg aaatcatgtc tcccctgggg atctctgtgt ttcggtgtgt   2040

gcgcctctta agaatcttca aagtgaccag gcactggact tccctgagca acttagtggc   2100

atccttatta aactccatga agtccatcgc ttcgctgttg cttctgcttt ttctcttcat   2160

tatcatcttt tccttgcttg ggatgcagct gtttggcggc aagtttaatt ttgatgaaac   2220

gcaaaccaag cggagcacct ttgacaattt ccctcaagca cttctcacag tgttccagat   2280

cctgacaggc gaagactgga atgctgtgat gtacgatggc atcatggctt acgggggccc   2340

atcctcttca ggaatgatcg tctgcatcta cttcatcatc ctcttcattt gtggtaacta   2400

tattctactg aatgtcttct tggccatcgc tgtagacaat ttggctgatg ctgaaagtct   2460

gaacactgct cagaaagaag aagcggaaga aaaggagagg aaaaagattg ccagaaaaga   2520

gagcctagaa aataaaaaga acaacaaacc agaagtcaac cagatagcca acagtgacaa   2580

caaggttaca attgatgact atagagaaga ggatgaagac aaggacccct atccgccttg   2640

cgatgtgcca gtaggggaag aggaagagga agaggaggag gatgaacctg aggttcctgc   2700

cggaccccgt cctcgaagga tctcggagtt gaacatgaag gaaaaaattg cccccatccc   2760

tgaagggagc gctttcttca ttcttagcaa gaccaacccg atccgcgtag gctgccacaa   2820

gctcatcaac caccacatct tcaccaacct catccttgtc ttcatcatgc tgagcagcgc   2880

tgccctggcc gcagaggacc ccatccgcag ccactccttc cggaacacga tactgggtta   2940

ctttgactat gccttcacag ccatctttac tgttgagatc ctgttgaaga tgacaacttt   3000

tggagctttc ctccacaaag gggccttctg caggaactac ttcaatttgc tggatatgct   3060

ggtggttggg gtgtctctgg tgtcatttgg gattcaatcc agtgccatct ccgttgtgaa   3120

gattctgagg gtcttaaggg tcctgcgtcc cctcagggcc atcaacagag caaaaggact   3180

taagcacgtg gtccagtgcg tcttcgtggc catccggacc atcggcaaca tcatgatcgt   3240

caccaccctc ctgcagttca tgtttgcctg tatcggggtc cagttgttca aggggaagtt   3300

ctatcgctgt acggatgaag ccaaaagtaa ccctgaagaa tgcaggggac ttttcatcct   3360

ctacaaggat ggggatgttg acagtcctgt ggtccgtgaa cggatctggc aaaacagtga   3420

tttcaacttc gacaacgtcc tctctgctat gatggcgctc ttcacagtct ccacgtttga   3480

gggctggcct gcgttgctgt ataaagccat cgactcgaat ggagagaaca tcggcccaat   3540

ctacaaccac cgcgtggaga tctccatctt cttcatcatc tacatcatca ttgtagcttt   3600

cttcatgatg aacatctttg tgggctttgt catcgttaca tttcaggaac aaggagaaaa   3660

agagtataag aactgtgagc tggacaaaaa tcagcgtcag tgtgttgaat acgccttgaa   3720

agcacgtccc ttgcggagat acatccccaa aaacccctac cagtacaagt tctggtacgt   3780

ggtgaactct tcgcctttcg aatacatgat gtttgtcctc atcatgctca acacactctg   3840

cttggccatg cagcactacg agcagtccaa gatgttcaat gatgccatgg acattctgaa   3900

catggtcttc accggggtgt tcaccgtcga gatggttttg aaagtcatcg catttaagcc   3960

taaggggtat tttagtgacg cctggaacac gtttgactcc ctcatcgtaa tcggcagcat   4020

tatagacgtg gccctcagcg aagcagaccc aactgaaagt gaaaatgtcc ctgtcccaac   4080

tgctacacct gggaactctg aagagagcaa tagaatctcc atcacctttt tccgtctttt   4140

ccgagtgatg cgattggtga agcttctcag caggggggaa ggcatccgga cattgctgtg   4200

gacttttatt aagtcctttc aggcgctccc gtatgtggcc ctcctcatag ccatgctgtt   4260

cttcatctat gcggtcattg gcatgcagat gtttgggaaa gttgccatga gagataacaa   4320

ccagatcaat aggaacaata acttccagac gtttccccag gcggtgctgc tgctcttcag   4380

gtgtgcaaca ggtgaggcct ggcaggagat catgctggcc tgtctcccag ggaagctctg   4440

tgaccctgag tcagattaca accccgggga ggagtataca tgtgggagca actttgccat   4500

tgtctatttc atcagttttt acatgctctg tgcatttctg atcatcaatc tgtttgtggc   4560

tgtcatcatg gataatttcg actatctgac ccgggactgg tctattttgg ggcctcacca   4620

tttagatgaa ttcaaaagaa tatggtcaga atatgaccct gaggcaaagg gaaggataaa   4680

acaccttgat gtggtcactc tgcttcgacg catccagcct cccctggggt ttgggaagtt   4740

atgtccacac agggtagcgt gcaagagatt agttgccatg aacatgcctc tcaacagtga   4800

cgggacagtc atgtttaatg caaccctgtt tgctttggtt cgaacggctc ttaagatcaa   4860

gaccgaaggg aacctggagc aagctaatga agaacttcgg gctgtgataa agaaaatttg   4920

gaagaaaacc agcatgaaat tacttgacca agttgtccct ccagctggtg atgatgaggt   4980

aaccgtgggg aagttctatg ccactttcct gatacaggac tactttagga aattcaagaa   5040

acggaaagaa caaggactgg tgggaaagta ccctgcgaag aacaccacaa ttgccctaca   5100

ggcgggatta aggacactgc atgacattgg gccagaaatc cggcgtgcta tatcgtgtga   5160

tttgcaagat gacgagcctg aggaaacaaa acgagaagaa gaagatgatg tgttcaaaag   5220

aaatggtgcc ctgcttggaa accatgtcaa tcatgttaat agtgatagga gagattccct   5280

tcagcagacc aataccaccc accgtcccct gcatgtccaa aggccttcaa ttccacctgc   5340

aagtgatact gagaaaccgc tgtttcctcc agcaggaaat tcggtgtgtc ataaccatca   5400

taaccataat tccataggaa agcaagttcc cacctcaaca aatgccaatc tcaataatgc   5460

caatatgtcc aaagctgccc atggaaagcg gcccagcatt gggaaccttg agcatgtgtc   5520

tgaaaatggg catcattctt cccacaagca tgaccgggag cctcagagaa ggtccagtgt   5580

gaaaagaacc cgctattatg aaacttacat taggtccgac tcaggagatg aacagctccc   5640

aactatttgc cgggaagacc cagagataca tggctatttc agggaccccc actgcttggg   5700

ggagcaggag tatttcagta gtgaggaatg ctacgaggat gacagctcgc ccacctggag   5760

caggcaaaac tatggctact acagcagata cccaggcaga aacatcgact ctgagaggcc   5820

ccgaggctac catcatcccc aaggattctt ggaggacgat gactcgcccg tttgctatga   5880

ttcacggaga tctccaagga gacgcctact acctcccacc ccagcatccc accggagatc   5940

ctccttcaac tttgagtgcc tgcgccggca gagcagccag gaagaggtcc cgtcgtctcc   6000

catcttcccc catcgcacgg ccctgcctct gcatctaatg cagcaacaga tcatggcagt   6060

tgccggccta gattcaagta aagcccagaa gtactcaccg agtcactcga cccggtcgtg   6120

ggccacccct ccagcaaccc ctccctaccg ggactggaca ccgtgctaca cccccctgat   6180

ccaagtggag cagtcagagg ccctggacca ggtgaacggc agcctgccgt ccctgcaccg   6240

cagctcctgg tacacagacg agcccgacat ctcctaccgg actttcacac cagccagcct   6300

gactgtcccc agcagcttcc ggaacaaaaa cagcgacaag cagaggagtg cggacagctt   6360

ggtggaggca gtcctgatat ccgaaggctt gggacgctat gcaagggacc caaaatttgt   6420

gtcagcaaca aaacacgaaa tcgctgatgc ctgtgacctc accatcgacg agatggagag   6480

tgcagccagc accctgctta atgggaacgt gcgtccccga gccaacgggg atgtgggccc   6540

cctctcacac cggcaggact atgagctaca ggactttggt cctggctaca gcgacgaaga   6600

gccagaccct gggagggatg aggaggacct ggcggatgaa atgatatgca tcaccacctt   6660

gtagccccca gcgaggggca gactggctct ggcctcaggt ggggcgcagg agagccaggg   6720

gaaaagtgcc tcatagttag gaaagtttag gcactagttg ggagtaatat tcaattaatt   6780

agacttttgt ataagagatg tcatgcctca agaaagccat aaacctggta ggaacaggtc   6840

ccaagcggtt gagcctggca gagtaccatg cgctcggccc cagctgcagg aaacagcagg   6900

ccccgccctc tcacagagga tgggtgagga ggccagacct gccctgcccc attgtccaga   6960

tgggcactgc tgtggagtct gcttctccca tgtaccaggg caccaggccc acccaactga   7020

aggcatggcg gcggggtgca ggggaaagtt aaaggtgatg acgatcatca cacctgtgtc   7080

gttacctcag ccatcggtct agcatatcag tcactgggcc caacatatcc atttttaaac   7140

cctttccccc aaatacactg cgtcctggtt cctgtttagc tgttctgaaa tacggtgtgt   7200

aagtaagtca gaacccagct accagtgatt attgcgaggg caatgggacc tcataaataa   7260

ggttttctgt gatgtgacgc cagtttacat aagagaatat cactccgatg gtcggtttct   7320

gactgtcacg ctaagggcaa ctgtaaactg gaataataat gcactcgcaa ccaggtaaac   7380

ttagatacac tagtttgttt aaaattatag atttactgta catgacttgt aatatactat   7440

aatttgtatt tgtaaagaga tggtctatat tttgtaatta ctgtattgta tttgaactgc   7500

agcaatatcc atgggtccta ataattgtag ttccccacta aaatctagaa attattagta   7560

tttttactcg ggctatccag aagtagaaga aatagagcca attctcattt attcagcgaa   7620

aatcctctgg ggttaaaatt ttaagtttga aagaacttga cactacagaa atttttctaa   7680

aatattttga gtcactataa acctatcatc tttccacaag atataccaga tgactatttg   7740

cagtcttttc tttgggcaag agttccatga ttttgatact gtacctttgg atccaccatg   7800

ggttgcaact gtctttggtt ttgtttgttt gacttgaacc accctctggt aagtaagtaa   7860

gtgaattaca gagcaggtcc agctggctgc tctgcccctt gggtatccat agttacggtt   7920

ttctctgtgg cccacccagg gtgttttttg catcgctggt gcagaaatgc ataggtggat   7980

gagatatagc tgctcttgtc ctctggggac tggtggtgct gcttaagaaa taaggggtgc   8040

tggggacaga ggagcaacgt ggtgatctat aggattggag tgtcggggtc tgtacaaatc   8100

gtattgttgc cttttacaaa actgctgtac tgtatgttct ctttgagggc ttttatatgc   8160

aattgaatga gggctgaagt tttcattaga at                                 8192


<210>  9326
<211>  2181
<212>  PRT
<213>  Homosapiens

<400>  9326

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365             


Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Trp Cys Trp Trp 
                485                 490                 495     


Arg Arg Arg Gly Ala Ala Lys Ala Gly Pro Ser Gly Cys Arg Arg Trp 
            500                 505                 510         


Gly Gln Ala Ile Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp 
        515                 520                 525             


Asn Arg Phe Asn Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr 
    530                 535                 540                 


Phe Tyr Trp Leu Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile 
545                 550                 555                 560 


Ser Ser Glu His Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp 
                565                 570                 575     


Ile Ala Asn Lys Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val 
            580                 585                 590         


Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn 
        595                 600                 605             


Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu 
    610                 615                 620                 


Val Glu Leu Glu Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys 
625                 630                 635                 640 


Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu 
                645                 650                 655     


Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser 
            660                 665                 670         


Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly 
        675                 680                 685             


Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys 
    690                 695                 700                 


Arg Ser Thr Phe Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln 
705                 710                 715                 720 


Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met 
                725                 730                 735     


Ala Tyr Gly Gly Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe 
            740                 745                 750         


Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu 
        755                 760                 765             


Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala 
    770                 775                 780                 


Gln Lys Glu Glu Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys 
785                 790                 795                 800 


Glu Ser Leu Glu Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile 
                805                 810                 815     


Ala Asn Ser Asp Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp 
            820                 825                 830         


Glu Asp Lys Asp Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg 
    850                 855                 860                 


Pro Arg Arg Ile Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile 
865                 870                 875                 880 


Pro Glu Gly Ser Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg 
                885                 890                 895     


Val Gly Cys His Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile 
            900                 905                 910         


Leu Val Phe Ile Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro 
        915                 920                 925             


Ile Arg Ser His Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr 
    930                 935                 940                 


Ala Phe Thr Ala Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr 
945                 950                 955                 960 


Phe Gly Ala Phe Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn 
                965                 970                 975     


Leu Leu Asp Met Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile 
            980                 985                 990         


Gln Ser Ser Ala Ile Ser Val Val  Lys Ile Leu Arg Val  Leu Arg Val 
        995                 1000                 1005             


Leu Arg  Pro Leu Arg Ala Ile  Asn Arg Ala Lys Gly  Leu Lys His 
    1010                 1015                 1020             


Val Val  Gln Cys Val Phe Val  Ala Ile Arg Thr Ile  Gly Asn Ile 
    1025                 1030                 1035             


Met Ile  Val Thr Thr Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly 
    1040                 1045                 1050             


Val Gln  Leu Phe Lys Gly Lys  Phe Tyr Arg Cys Thr  Asp Glu Ala 
    1055                 1060                 1065             


Lys Ser  Asn Pro Glu Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys 
    1070                 1075                 1080             


Asp Gly  Asp Val Asp Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln 
    1085                 1090                 1095             


Asn Ser  Asp Phe Asn Phe Asp  Asn Val Leu Ser Ala  Met Met Ala 
    1100                 1105                 1110             


Leu Phe  Thr Val Ser Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr 
    1115                 1120                 1125             


Lys Ala  Ile Asp Ser Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn 
    1130                 1135                 1140             


His Arg  Val Glu Ile Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile 
    1145                 1150                 1155             


Val Ala  Phe Phe Met Met Asn  Ile Phe Val Gly Phe  Val Ile Val 
    1160                 1165                 1170             


Thr Phe  Gln Glu Gln Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu 
    1175                 1180                 1185             


Asp Lys  Asn Gln Arg Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg 
    1190                 1195                 1200             


Pro Leu  Arg Arg Tyr Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe 
    1205                 1210                 1215             


Trp Tyr  Val Val Asn Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val 
    1220                 1225                 1230             


Leu Ile  Met Leu Asn Thr Leu  Cys Leu Ala Met Gln  His Tyr Glu 
    1235                 1240                 1245             


Gln Ser  Lys Met Phe Asn Asp  Ala Met Asp Ile Leu  Asn Met Val 
    1250                 1255                 1260             


Phe Thr  Gly Val Phe Thr Val  Glu Met Val Leu Lys  Val Ile Ala 
    1265                 1270                 1275             


Phe Lys  Pro Lys Gly Tyr Phe  Ser Asp Ala Trp Asn  Thr Phe Asp 
    1280                 1285                 1290             


Ser Leu  Ile Val Ile Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu 
    1295                 1300                 1305             


Ala Asp  Pro Thr Glu Ser Glu  Asn Val Pro Val Pro  Thr Ala Thr 
    1310                 1315                 1320             


Pro Gly  Asn Ser Glu Glu Ser  Asn Arg Ile Ser Ile  Thr Phe Phe 
    1325                 1330                 1335             


Arg Leu  Phe Arg Val Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly 
    1340                 1345                 1350             


Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln 
    1355                 1360                 1365             


Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile 
    1370                 1375                 1380             


Tyr Ala  Val Ile Gly Met Gln  Met Phe Gly Lys Val  Ala Met Arg 
    1385                 1390                 1395             


Asp Asn  Asn Gln Ile Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro 
    1400                 1405                 1410             


Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp 
    1415                 1420                 1425             


Gln Glu  Ile Met Leu Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro 
    1430                 1435                 1440             


Glu Ser  Asp Tyr Asn Pro Gly  Glu Glu Tyr Thr Cys  Gly Ser Asn 
    1445                 1450                 1455             


Phe Ala  Ile Val Tyr Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe 
    1460                 1465                 1470             


Leu Ile  Ile Asn Leu Phe Val  Ala Val Ile Met Asp  Asn Phe Asp 
    1475                 1480                 1485             


Tyr Leu  Thr Arg Asp Trp Ser  Ile Leu Gly Pro His  His Leu Asp 
    1490                 1495                 1500             


Glu Phe  Lys Arg Ile Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly 
    1505                 1510                 1515             


Arg Ile  Lys His Leu Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln 
    1520                 1525                 1530             


Pro Pro  Leu Gly Phe Gly Lys  Leu Cys Pro His Arg  Val Ala Cys 
    1535                 1540                 1545             


Lys Arg  Leu Val Ala Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr 
    1550                 1555                 1560             


Val Met  Phe Asn Ala Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu 
    1565                 1570                 1575             


Lys Ile  Lys Thr Glu Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu 
    1580                 1585                 1590             


Arg Ala  Val Ile Lys Lys Ile  Trp Lys Lys Thr Ser  Met Lys Leu 
    1595                 1600                 1605             


Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val 
    1610                 1615                 1620             


Gly Lys  Phe Tyr Ala Thr Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys 
    1625                 1630                 1635             


Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala 
    1640                 1645                 1650             


Lys Asn  Thr Thr Ile Ala Leu  Gln Ala Gly Leu Arg  Thr Leu His 
    1655                 1660                 1665             


Asp Ile  Gly Pro Glu Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln 
    1670                 1675                 1680             


Asp Asp  Glu Pro Glu Glu Thr  Lys Arg Glu Glu Glu  Asp Asp Val 
    1685                 1690                 1695             


Phe Lys  Arg Asn Gly Ala Leu  Leu Gly Asn His Val  Asn His Val 
    1700                 1705                 1710             


Asn Ser  Asp Arg Arg Asp Ser  Leu Gln Gln Thr Asn  Thr Thr His 
    1715                 1720                 1725             


Arg Pro  Leu His Val Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp 
    1730                 1735                 1740             


Thr Glu  Lys Pro Leu Phe Pro  Pro Ala Gly Asn Ser  Val Cys His 
    1745                 1750                 1755             


Asn His  His Asn His Asn Ser  Ile Gly Lys Gln Val  Pro Thr Ser 
    1760                 1765                 1770             


Thr Asn  Ala Asn Leu Asn Asn  Ala Asn Met Ser Lys  Ala Ala His 
    1775                 1780                 1785             


Gly Lys  Arg Pro Ser Ile Gly  Asn Leu Glu His Val  Ser Glu Asn 
    1790                 1795                 1800             


Gly His  His Ser Ser His Lys  His Asp Arg Glu Pro  Gln Arg Arg 
    1805                 1810                 1815             


Ser Ser  Val Lys Arg Thr Arg  Tyr Tyr Glu Thr Tyr  Ile Arg Ser 
    1820                 1825                 1830             


Asp Ser  Gly Asp Glu Gln Leu  Pro Thr Ile Cys Arg  Glu Asp Pro 
    1835                 1840                 1845             


Glu Ile  His Gly Tyr Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln 
    1850                 1855                 1860             


Glu Tyr  Phe Ser Ser Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro 
    1865                 1870                 1875             


Thr Trp  Ser Arg Gln Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly 
    1880                 1885                 1890             


Arg Asn  Ile Asp Ser Glu Arg  Pro Arg Gly Tyr His  His Pro Gln 
    1895                 1900                 1905             


Gly Phe  Leu Glu Asp Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg 
    1910                 1915                 1920             


Arg Ser  Pro Arg Arg Arg Leu  Leu Pro Pro Thr Pro  Ala Ser His 
    1925                 1930                 1935             


Arg Arg  Ser Ser Phe Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser 
    1940                 1945                 1950             


Gln Glu  Glu Val Pro Ser Ser  Pro Ile Phe Pro His  Arg Thr Ala 
    1955                 1960                 1965             


Leu Pro  Leu His Leu Met Gln  Gln Gln Ile Met Ala  Val Ala Gly 
    1970                 1975                 1980             


Leu Asp  Ser Ser Lys Ala Gln  Lys Tyr Ser Pro Ser  His Ser Thr 
    1985                 1990                 1995             


Arg Ser  Trp Ala Thr Pro Pro  Ala Thr Pro Pro Tyr  Arg Asp Trp 
    2000                 2005                 2010             


Thr Pro  Cys Tyr Thr Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala 
    2015                 2020                 2025             


Leu Asp  Gln Val Asn Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser 
    2030                 2035                 2040             


Trp Tyr  Thr Asp Glu Pro Asp  Ile Ser Tyr Arg Thr  Phe Thr Pro 
    2045                 2050                 2055             


Ala Ser  Leu Thr Val Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp 
    2060                 2065                 2070             


Lys Gln  Arg Ser Ala Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2075                 2080                 2085             


Glu Gly  Leu Gly Arg Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala 
    2090                 2095                 2100             


Thr Lys  His Glu Ile Ala Asp  Ala Cys Asp Leu Thr  Ile Asp Glu 
    2105                 2110                 2115             


Met Glu  Ser Ala Ala Ser Thr  Leu Leu Asn Gly Asn  Val Arg Pro 
    2120                 2125                 2130             


Arg Ala  Asn Gly Asp Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr 
    2135                 2140                 2145             


Glu Leu  Gln Asp Phe Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp 
    2150                 2155                 2160             


Pro Gly  Arg Asp Glu Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile 
    2165                 2170                 2175             


Thr Thr  Leu 
    2180     


<210>  9327
<211>  2380
<212>  DNA
<213>  Homosapiens

<400>  9327
ggcatgggca gtggcagaat tggccctggt agagagcaga gctgatgcca tccttttggc     60

aaatagctga cattttatgg tgtggtgctg ggtgagcccc ctgtgagggg tgaacagatg    120

tggacaggac ttgggtccag gcactagaga aatggtgcag cctgtaagaa tgccagtttg    180

taagtactga ctttggaaaa gatcatcgcc tctatcagac acttagggtc ctggtctggc    240

aattttggcc tgatgtgatg ccacaagacc caacagagag agacacagag tccaggataa    300

tgttgacagt ggtgtagccc tttaggagaa atggcgctcc ctgcggctgg tattaggtta    360

ccattggcac cgaaggaacc aggaggataa gaatatccat aatttcagag ctgccctggc    420

acagtacctg ccctgtcgga ggctctcact ggcaaatgac agctctgtgc aaggagcact    480

cccaagtata aaaattatta cacagtttta ttctgaagaa cattttgcat tttaataaaa    540

aaggatttat gtcaggaaag agtcatttac aaaccttgaa gtgtttttgc ctggatcaga    600

gtaagaatgt cttaagaaga ggtttgtaag gtcttcataa caaagtggtg tttgttattt    660

acaaaaaaaa aaaaaaaaaa aaaaattaac aggttgtctg tatactatta aaaattttgg    720

accaaaattg ctacctatca tctatctttt tgattgcagg gaatccctgc caaggtaacc    780

tgacagtcgg cctaattctg ttgacagaaa atgaagcctt gacggttcta attatccaaa    840

agtgggtttt catcaggacg tacagtcaga gtgtgagtgc attctaatga aaacttcagc    900

cctcattcaa ttgcatataa aagccctcaa agagaacata cagtacagca gttttgtaaa    960

aggcaacaat acgatttgta cagaccccga cactccaatc ctatagatca ccacgttgct   1020

cctctgtccc cagcacccct tatttcttaa gcagcaccac cagtccccag aggacaagag   1080

cagctatatc tcatccacct atgcatttct gcaccagcga tgcaaaaaac accctgggtg   1140

ggccacagag aaaaccgtaa ctatggatac ccaaggggca gagcagccag ctggacctgc   1200

tctgtaattc acttacttac ttaccagagg gtggttcaag tcaaacaaac aaaaccaaag   1260

acagttgcaa cccatggtgg atccaaaggt acagtatcaa aatcatggaa ctcttgccca   1320

aagaaaagac tgcaaatagt catctggtat atcttgtgga aagatgatag gtttatagtg   1380

actcaaaata ttttagaaaa atttctgtag tgtcaagttc tttcaaactt aaaattttaa   1440

ccccagagga ttttcgctga ataaatgaga attggctcta tttcttctac ttctggatag   1500

cccgagtaaa aatactaata atttctagat tttagtgggg aactacaatt attaggaccc   1560

atggatattg ctgcagttca aatacaatac agtaattaca aaatatagac catctcttta   1620

caaatacaaa ttatagtata ttacaagtca tgtacagtaa atctataatt ttaaacaaac   1680

tagtgtatct aagtttacct ggttgcgagt gcattattat tccagtttac agttgccctt   1740

agcgtgacag tcagaaaccg accatcggag tgatattctc ttatgtaaac tggcgtcaca   1800

tcacagaaaa ccttatttat gaggtcccat tgccctcgca ataatcactg gtagctgggt   1860

tctgacttac ttacacaccg tatttcagaa cagctaaaca ggaaccagga cgcagtgtat   1920

ttgggggaaa gggtttaaaa atggatatgt tgggcccagt gactgatatg ctagaccgat   1980

ggctgaggta acgacacagg tgtgatgatc gtcatcacct ttaactttcc cctgcacccc   2040

gccgccatgc cttcagttgg gtgggcctgg tgccctggta catgggagaa gcagactcca   2100

cagcagtgcc catctggaca atggggcagg gcaggtctgg cctcctcacc catcctctgt   2160

gagagggcgg ggcctgctgt ttcctgcagc tggggccgag cgcatggtac tctgccaggc   2220

tcaaccgctt gggacctgtt cctaccaggt ttatggcttt cttgaggcat gacatctctt   2280

atacaaaagt ctaattaatt gaatattact cccaactagt gcctaaactt tcctaactat   2340

gaggcacttt tcccctggct ctcctgcgcc ccacctgagg                         2380


<210>  9328
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  9328

Met Gln Lys Thr Pro Trp Val Gly His Arg Glu Asn Arg Asn Tyr Gly 
1               5                   10                  15      


Tyr Pro Arg Gly Arg Ala Ala Ser Trp Thr Cys Ser Val Ile His Leu 
            20                  25                  30          


Leu Thr Tyr Gln Arg Val Val Gln Val Lys Gln Thr Lys Pro Lys Thr 
        35                  40                  45              


Val Ala Thr His Gly Gly Ser Lys Gly Thr Val Ser Lys Ser Trp Asn 
    50                  55                  60                  


Ser Cys Pro Lys Lys Arg Leu Gln Ile Val Ile Trp Tyr Ile Leu Trp 
65                  70                  75                  80  


Lys Asp Asp Arg Phe Ile Val Thr Gln Asn Ile Leu Glu Lys Phe Leu 
                85                  90                  95      


<210>  9329
<211>  854
<212>  DNA
<213>  Homosapiens

<400>  9329
ttgctcctct gtccccagca ccccttattt cttaagcagc accaccagtc cccagaggac     60

aagagcagct atatctcatc cacctatgca tttctgcacc agcgatgcaa aaaacaccct    120

gggtgggcca cagagaaaac cgtaactatg gatacccaag gggcagagca gccagctgga    180

cctgctctgt aattcactta cttacttacc agagggtggt tcaagtcaaa caaacaaaac    240

caaagacagt tgcaacccat ggtggatcca aaggtacagt atcaaaatca tggaactctt    300

gcccaaagaa aagactgcaa atagtcatct ggtatatctt gtggaaagat gataggttta    360

tagtgactca aaatatttta gaaaaatttc tgtagtgtca agttctttca aacttaaaat    420

tttaacccca gaggattttc gctgaataaa tgagaattgg ctctatttct tctacttctg    480

gatagcccga gtaaaaatac taataatttc tagattttag tggggaacta caattattag    540

gacccatgga tattgctgca gttcaaatac aatacagtaa ttacaaaata tagaccatct    600

ctttacaaat acaaattata gtatattaca agtcatgtac agtaaatcta taattttaaa    660

caaactagtg tatctaagtt tacctggttg cgagtgcatt attattccag tttacagttg    720

cccttagcgt gacagtcaga aaccgaccat cggagtgata ttctcttatg taaactggcg    780

tcacatcaca gaaaacctta ttgtatttgg gggaaagggt ttaaaaatgg atatgttggg    840

cccagtgact gata                                                      854


<210>  9330
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  9330

Met Gln Lys Thr Pro Trp Val Gly His Arg Glu Asn Arg Asn Tyr Gly 
1               5                   10                  15      


Tyr Pro Arg Gly Arg Ala Ala Ser Trp Thr Cys Ser Val Ile His Leu 
            20                  25                  30          


Leu Thr Tyr Gln Arg Val Val Gln Val Lys Gln Thr Lys Pro Lys Thr 
        35                  40                  45              


Val Ala Thr His Gly Gly Ser Lys Gly Thr Val Ser Lys Ser Trp Asn 
    50                  55                  60                  


Ser Cys Pro Lys Lys Arg Leu Gln Ile Val Ile Trp Tyr Ile Leu Trp 
65                  70                  75                  80  


Lys Asp Asp Arg Phe Ile Val Thr Gln Asn Ile Leu Glu Lys Phe Leu 
                85                  90                  95      


<210>  9331
<211>  723
<212>  DNA
<213>  Homosapiens

<400>  9331
ggcatgggca gtggcagaat tggccctggt agagagcaga gctgatgcca tccttttggc     60

aaatagctga cattttatgg tgtggtgctg ggtgagcccc ctgtgagggg tgaacagatg    120

tggacaggac ttgggtccag gcactagaga aatggtgcag cctgtaagaa tgccagtttg    180

taagtactga ctttggaaaa gatcatcgcc tctatcagac acttagggtc ctggtctggc    240

aattttggcc tgatgtgatg ccacaagacc caacagagag agacacagag tccaggataa    300

tgttgacagt ggtgtagccc tttaggagaa atggcgctcc ctgcggctgg tattaggtta    360

ccattggcac cgaaggaacc aggaggataa gaatatccat aatttcagag ctgccctggc    420

acagtacctg ccctgtcgga ggctctcact ggcaaatgac agctctgtgc aaggagcact    480

cccaagtata aaaattatta cacagtttta ttctgaagaa cattttgcat tttaataaaa    540

aaggatttat gtcaggaaag agtcatttac aaaccttgaa gtgtttttgc ctggatcaga    600

gtaagaatgt cttaagaaga ggtttgtaag gtcttcataa caaagtggtg tttgttattt    660

acaaaaaaaa aaaaaaaaaa aaaaattaac aggttgtctg tatactatta aaaattttgg    720

acc                                                                  723


<210>  9332
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  9332

Glu Lys Trp Arg Ser Leu Arg Leu Val Leu Gly Tyr His Trp His Arg 
1               5                   10                  15      


Arg Asn Gln Glu Asp Lys Asn Ile His Asn Phe Arg Ala Ala Leu Ala 
            20                  25                  30          


Gln Tyr Leu Pro Cys Arg Arg Leu Ser Leu Ala Asn Asp Ser Ser Val 
        35                  40                  45              


Gln Gly Ala Leu Pro Ser Ile Lys Ile Ile Thr Gln Phe Tyr Ser Glu 
    50                  55                  60                  


Glu His Phe Ala Phe 
65                  


<210>  9333
<211>  1112
<212>  DNA
<213>  Homosapiens

<400>  9333
aagccctggc tccgttccga gggaaagagc tccagccagg aagccacatt cagtcagata     60

aagagataga tgcctttgtg cgggcaaaag ccgacagcgc ctaccacccc tcgtgcacct    120

gtaagatggg ccagccctcc gatcccactg ccgtggtgga tccgcagaca agggtcctcg    180

gggtggaaaa cctcagggtc gtcgatgcct ccatcatgcc tagcatggtc agcggcaacc    240

tgaacgcccc cacaatcatg atcgcagaga aggcagctga cattatcaag gggcagcctg    300

cactctggga caaagatgtc cctgtctaca agcccaggac gctggccacc cagcgctaag    360

acagttgctg ctggaggatg accagggaag ccccctgata agccaagagg gccagcacag    420

cccttgctcc caggctcctg cctgaaacta tctagcacac taggacccag gtggtaccct    480

actcagtggc tgagaattgg ataaagtctt gggaaatgag acaagtactg ggcagtgaat    540

ccagctcctt ttccccagcc tttccctgtg ggccatttgg ggaaggccag cattcagcct    600

gagatgttcc tccctgcctc ctggagggac agaaggggag gatggttaac tcctgccgca    660

tcctttttct tgtgttcacg tggcattctc taacccaggg cagtggttcc ttcccaggcc    720

atgcacagag gctgggtgcc tgccagaccc acggagggtt cgcgaaggaa ggggcatcct    780

ccttcttgag ctgcaagctt tagctgaggc agtaagtcac acagtagtta gttcagcctg    840

ggctggcaca taagtcccca gtgtccctgt tgagagggga aagttgcctg ctggttgaaa    900

aactggcttt tcctttctcg ctgcctaatt tcactctcag agtgaggcag gtaactgggg    960

ctccactggg tcactctgag agggttgtgg ctctggttct tattaaacca gggccaggtg   1020

cagggctcac acctgtaatc ccagcacttt gggaaggtca cctgatggca ccactgcact   1080

ccagcctggg tgacagggtg agaccctgtc tc                                 1112


<210>  9334
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  9334

Met Gly Gln Pro Ser Asp Pro Thr Ala Val Val Asp Pro Gln Thr Arg 
1               5                   10                  15      


Val Leu Gly Val Glu Asn Leu Arg Val Val Asp Ala Ser Ile Met Pro 
            20                  25                  30          


Ser Met Val Ser Gly Asn Leu Asn Ala Pro Thr Ile Met Ile Ala Glu 
        35                  40                  45              


Lys Ala Ala Asp Ile Ile Lys Gly Gln Pro Ala Leu Trp Asp Lys Asp 
    50                  55                  60                  


Val Pro Val Tyr Lys Pro Arg Thr Leu Ala Thr Gln Arg 
65                  70                  75          


<210>  9335
<211>  2388
<212>  DNA
<213>  Homosapiens

<400>  9335
gccgtgtccg agcgctggcg gagcacgggc cgccgcggcg cgcgcctacc cccgcgcaca     60

cgtgcatgca gtgagccagg tgcatcagct gcacccgccc tcgggcttcg cgcgcctccg    120

ctggagccca gctagcctcg cggctccggg gccgaccggg tcggaactgc tgcgtcccca    180

ttccggacgc agagagcgcg cggggcgccg gcgccgccgg ttaaagtgcc gcggggcagg    240

ggccgggccg cggccacccg ctcctcccgc tccggtcccg actgtcgggc tctcggccga    300

gtcgccccgg acaatcacaa agagtgtgta ggccagcccc ggtcacagag tgcaccgtat    360

cctgtcactt ctggatgtga gggagaagtg agtcatctca ttcccctccg tggatcagag    420

gacttggact agatagaagc atgtggtgtc tcctacgagg cctgggccgg cctggagccc    480

tggcacgggg agccctgggg cagcagcaat ccctgggtgc ccgggccctg gccagcgcag    540

gctctgagag ccgggacgag tacagctatg tggtggtggg cgcgggctcg gcgggctgcg    600

tgctggctgg gaggctcacg gaggaccccg ccgagcgcgt gctgctgctg gaggccgggc    660

ccaaggacgt gctcgcgggg agcaagcggc tctcgtggaa gatccacatg cccgcggccc    720

tggtggccaa cctgtgcgac gacaggtaca actggtgcta ccacacagag gtgcagcggg    780

gcctggacgg ccgcgtgctg tactggccac gcggccgcgt ctggggtggc tcctcatccc    840

tcaatgccat ggtctacgtc cgtgggcacg ccgaggacta cgagcgctgg cagcgccagg    900

gcgcccgcgg ctgggactac gcgcactgcc tgccctactt ccgcaaggcg cagggccacg    960

agctgggcgc cagccggtac cggggcgccg atggcccgct gcgggtgtcc cggggcaaga   1020

ccaaccaccc gctgcactgc gcattcctgg aggccacgca gcaggccggc tacccgctca   1080

ccgaggacat gaatggcttc cagcaggagg gcttcggctg gatggacatg accatccatg   1140

aaggcaaacg gtggagcgcg gcctgtgcct acctgcaccc agcactgagc cgcaccaacc   1200

tcaaggccga ggccgagacg cttgtgagca gggtgctatt tgagggcacc cgtgcagtgg   1260

gcgtggagta tgtcaagaat ggccagagcc acagggctta tgccagcaag gaggtgattc   1320

tgagtggagg tgccatcaac tctccacagc tgctcatgct ctctggcatc gggaatgctg   1380

atgacctcaa gaaactgggc atccctgtgg tgtgccacct acctggggtt ggccagaacc   1440

tgcaagacca cctggagatc tacattcagc aggcatgcac ccgccctatc accctccatt   1500

cagcacagaa gcccctgcgg aaggtctgca ttggtctgga gtggctctgg aaattcacag   1560

gggagggagc cactgcccat ctggaaacag gtgggttcat ccgcagccag cctggggtcc   1620

cccacccgga catccagttc catttcctgc catcccaagt gattgaccac gggcgggtcc   1680

ccacccagca ggaggcttac caggtacatg tggggcccat gcggggcacg agtgtgggct   1740

ggctcaaact gagaagtgcc aatccccaag accaccctgt gatccagccc aactacttgt   1800

caacagaaac tgatattgag gatttccgtc tgtgtgtgaa gctcaccaga gaaatttttg   1860

cacaggaagc cctggctccg ttccgaggga aagagctcca gccaggaagc cacattcagt   1920

cagataaaga gatagatgcc tttgtgcggg caaaagccga cagcgcctac cacccctcgt   1980

gcacctgtaa gatgggccag ccctccgatc ccactgccgt ggtggatccg cagacaaggg   2040

tcctcggggt ggaaaacctc agggtcgtcg atgcctccat catgcctagc atggtcagcg   2100

gcaacctgaa cgcccccaca atcatgatcg cagagaaggc agctgacatt atcaaggggc   2160

agcctgcact ctgggacaaa gatgtccctg tctacaagcc caggacgctg gccacccagc   2220

gctaagacag ttgctgctgg aggatgacca gggaagcccc ctgataagcc aagagggcca   2280

gcacagccct tgctcccagg ctcctgcctg aaactatcta gcacactagg acccaggtgg   2340

taccctactc agtggctgag aattggataa agtcttggga aatgagac                2388


<210>  9336
<211>  594
<212>  PRT
<213>  Homosapiens

<400>  9336

Met Trp Cys Leu Leu Arg Gly Leu Gly Arg Pro Gly Ala Leu Ala Arg 
1               5                   10                  15      


Gly Ala Leu Gly Gln Gln Gln Ser Leu Gly Ala Arg Ala Leu Ala Ser 
            20                  25                  30          


Ala Gly Ser Glu Ser Arg Asp Glu Tyr Ser Tyr Val Val Val Gly Ala 
        35                  40                  45              


Gly Ser Ala Gly Cys Val Leu Ala Gly Arg Leu Thr Glu Asp Pro Ala 
    50                  55                  60                  


Glu Arg Val Leu Leu Leu Glu Ala Gly Pro Lys Asp Val Leu Ala Gly 
65                  70                  75                  80  


Ser Lys Arg Leu Ser Trp Lys Ile His Met Pro Ala Ala Leu Val Ala 
                85                  90                  95      


Asn Leu Cys Asp Asp Arg Tyr Asn Trp Cys Tyr His Thr Glu Val Gln 
            100                 105                 110         


Arg Gly Leu Asp Gly Arg Val Leu Tyr Trp Pro Arg Gly Arg Val Trp 
        115                 120                 125             


Gly Gly Ser Ser Ser Leu Asn Ala Met Val Tyr Val Arg Gly His Ala 
    130                 135                 140                 


Glu Asp Tyr Glu Arg Trp Gln Arg Gln Gly Ala Arg Gly Trp Asp Tyr 
145                 150                 155                 160 


Ala His Cys Leu Pro Tyr Phe Arg Lys Ala Gln Gly His Glu Leu Gly 
                165                 170                 175     


Ala Ser Arg Tyr Arg Gly Ala Asp Gly Pro Leu Arg Val Ser Arg Gly 
            180                 185                 190         


Lys Thr Asn His Pro Leu His Cys Ala Phe Leu Glu Ala Thr Gln Gln 
        195                 200                 205             


Ala Gly Tyr Pro Leu Thr Glu Asp Met Asn Gly Phe Gln Gln Glu Gly 
    210                 215                 220                 


Phe Gly Trp Met Asp Met Thr Ile His Glu Gly Lys Arg Trp Ser Ala 
225                 230                 235                 240 


Ala Cys Ala Tyr Leu His Pro Ala Leu Ser Arg Thr Asn Leu Lys Ala 
                245                 250                 255     


Glu Ala Glu Thr Leu Val Ser Arg Val Leu Phe Glu Gly Thr Arg Ala 
            260                 265                 270         


Val Gly Val Glu Tyr Val Lys Asn Gly Gln Ser His Arg Ala Tyr Ala 
        275                 280                 285             


Ser Lys Glu Val Ile Leu Ser Gly Gly Ala Ile Asn Ser Pro Gln Leu 
    290                 295                 300                 


Leu Met Leu Ser Gly Ile Gly Asn Ala Asp Asp Leu Lys Lys Leu Gly 
305                 310                 315                 320 


Ile Pro Val Val Cys His Leu Pro Gly Val Gly Gln Asn Leu Gln Asp 
                325                 330                 335     


His Leu Glu Ile Tyr Ile Gln Gln Ala Cys Thr Arg Pro Ile Thr Leu 
            340                 345                 350         


His Ser Ala Gln Lys Pro Leu Arg Lys Val Cys Ile Gly Leu Glu Trp 
        355                 360                 365             


Leu Trp Lys Phe Thr Gly Glu Gly Ala Thr Ala His Leu Glu Thr Gly 
    370                 375                 380                 


Gly Phe Ile Arg Ser Gln Pro Gly Val Pro His Pro Asp Ile Gln Phe 
385                 390                 395                 400 


His Phe Leu Pro Ser Gln Val Ile Asp His Gly Arg Val Pro Thr Gln 
                405                 410                 415     


Gln Glu Ala Tyr Gln Val His Val Gly Pro Met Arg Gly Thr Ser Val 
            420                 425                 430         


Gly Trp Leu Lys Leu Arg Ser Ala Asn Pro Gln Asp His Pro Val Ile 
        435                 440                 445             


Gln Pro Asn Tyr Leu Ser Thr Glu Thr Asp Ile Glu Asp Phe Arg Leu 
    450                 455                 460                 


Cys Val Lys Leu Thr Arg Glu Ile Phe Ala Gln Glu Ala Leu Ala Pro 
465                 470                 475                 480 


Phe Arg Gly Lys Glu Leu Gln Pro Gly Ser His Ile Gln Ser Asp Lys 
                485                 490                 495     


Glu Ile Asp Ala Phe Val Arg Ala Lys Ala Asp Ser Ala Tyr His Pro 
            500                 505                 510         


Ser Cys Thr Cys Lys Met Gly Gln Pro Ser Asp Pro Thr Ala Val Val 
        515                 520                 525             


Asp Pro Gln Thr Arg Val Leu Gly Val Glu Asn Leu Arg Val Val Asp 
    530                 535                 540                 


Ala Ser Ile Met Pro Ser Met Val Ser Gly Asn Leu Asn Ala Pro Thr 
545                 550                 555                 560 


Ile Met Ile Ala Glu Lys Ala Ala Asp Ile Ile Lys Gly Gln Pro Ala 
                565                 570                 575     


Leu Trp Asp Lys Asp Val Pro Val Tyr Lys Pro Arg Thr Leu Ala Thr 
            580                 585                 590         


Gln Arg 
        


<210>  9337
<211>  518
<212>  DNA
<213>  Homosapiens

<400>  9337
gcttggctgc tttcctacag cccagcagag cctcccagga gcacaaccgt ctgaataccc     60

agccctgtgg tgggctgagg ggagtgcagt gcagtggccc agggcatgga ttgccctcct    120

caccactgac cacatccatc ctgggacttc tctgtgccac ttactgggac ctcaacaggc    180

taatagtgag atgagctgtg gaaagcccac atccctggct gagggctcca cgcccttgcc    240

tcccaccatg tgctgagctt ggcctgaggc tggcgctgcg tcatgctggc caaggggaca    300

catgcagggg atgaggctgc acgtggccta cagcaaaccc aacctgcgca gtctgagatg    360

tggatgctga gctcatacac ctgtgccagg accaacagaa ggcaccccct gggaatgttc    420

tagatccaga cctggtgatg gttacccagg catacacaca gatcaaaacc aacatgatgg    480

acacttcgta tgtctgttgc acctcaatta aaatgttt                            518


<210>  9338
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  9338

Met Leu Ala Lys Gly Thr His Ala Gly Asp Glu Ala Ala Arg Gly Leu 
1               5                   10                  15      


Gln Gln Thr Gln Pro Ala Gln Ser Glu Met Trp Met Leu Ser Ser Tyr 
            20                  25                  30          


Thr Cys Ala Arg Thr Asn Arg Arg His Pro Leu Gly Met Phe 
        35                  40                  45      


<210>  9339
<211>  2044
<212>  DNA
<213>  Homosapiens

<400>  9339
agcgcagcgt gcgggtggcc tggatcccgc gcagtggccc ggcgatgtcg ctcgtgctgc     60

taagcctggc cgcgctgtgc aggagcgccg taccccgaga gccgaccgtt caatgtggct    120

ctgaaactgg gccatctcca gagtggatgc tacaacatga tctaatcccc ggagacttga    180

gggacctccg agtagaacct gttacaacta gtgttgcaac aggggactat tcaattttga    240

tgaatgtaag ctgggtactc cgggcagatg ccagcatccg cttgttgaag gccaccaaga    300

tttgtgtgac gggcaaaagc aacttccagt cctacagctg tgtgaggtgc aattacacag    360

aggccttcca gactcagacc agaccctctg gtggtaaatg gacattttcc tacatcggct    420

tccctgtaga gctgaacaca gtctatttca ttggggccca taatattcct aatgcaaata    480

tgaatgaaga tggcccttcc atgtctgtga atttcacctc accaggctgc ctagaccaca    540

taatgaaata taaaaaaaag tgtgtcaagg ccggaagcct gtgggatccg aacatcactg    600

cttgtaagaa gaatgaggag acagtagaag tgaacttcac aaccactccc ctgggaaaca    660

gatacatggc tcttatccaa cacagcacta tcatcgggtt ttctcaggtg tttgagccac    720

accagaagaa acaaacgcga gcttcagtgg tgattccagt gactggggat agtgaaggtg    780

ctacggtgca gctgactcca tattttccta cttgtggcag cgactgcatc cgacataaag    840

gaacagttgt gctctgccca caaacaggcg tccctttccc tctggataac aacaaaagca    900

agccgggagg ctggctgcct ctcctcctgc tgtctctgct ggtggccaca tgggtgctgg    960

tggcagggat ctatctaatg tggaggcacg aaaggatcaa gaagacttcc ttttctacca   1020

ccacactact gccccccatt aaggttcttg tggtttaccc atctgaaata tgtttccatc   1080

acacaatttg ttacttcact gaatttcttc aaaaccattg cagaagtgag gtcatccttg   1140

aaaagtggca gaaaaagaaa atagcagaga tgggtccagt gcagtggctt gccactcaaa   1200

agaaggcagc agacaaagtc gtcttccttc tttccaatga cgtcaacagt gtgtgcgatg   1260

gtacctgtgg caagagcgag ggcagtccca gtgagaactc tcaagacctc ttcccccttg   1320

cctttaacct tttctgcagt gatctaagaa gccagattca tctgcacaaa tacgtggtgg   1380

tctactttag agagattgat acaaaagacg attacaatgc tctcagtgtc tgccccaagt   1440

accacctcat gaaggatgcc actgctttct gtgcagaact tctccatgtc aagcagcagg   1500

tgtcagcagg aaaaagatca caagcctgcc acgatggctg ctgctccttg tagcccaccc   1560

atgagaagca agagacctta aaggcttcct atcccaccaa ttacagggaa aaaacgtgtg   1620

atgatcctga agcttactat gcagcctaca aacagcctta gtaattaaaa cattttatac   1680

caataaaatt ttcaaatatt gctaactaat gtagcattaa ctaacgattg gaaactacat   1740

ttacaacttc aaagctgttt tatacataga aatcaattac agttttaatt gaaaactata   1800

accattttga taatgcaaca ataaagcatc ttcagccaaa catctagtct tccatagacc   1860

atgcattgca gtgtacccag aactgtttag ctaatattct atgtttaatt aatgaatact   1920

aactctaaga acccctcact gattcactca atagcatctt aagtgaaaaa ccttctatta   1980

catgcaaaaa atcattgttt ttaagataac aaaagtaggg aataaacaag ctgaacccac   2040

tttt                                                                2044


<210>  9340
<211>  502
<212>  PRT
<213>  Homosapiens

<400>  9340

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  9341
<211>  3072
<212>  DNA
<213>  Homosapiens

<400>  9341
agcgcagcgt gcgggtggcc tggatcccgc gcagtggccc ggcgatgtcg ctcgtgctgc     60

taagcctggc cgcgctgtgc aggagcgccg taccccgaga gccgaccgtt caatgtggct    120

ctgaaactgg gccatctcca gagtggatgc tacaacatga tctaatcccc ggagacttga    180

gggacctccg agtagaacct gttacaacta gtgttgcaac aggggactat tcaattttga    240

tgaatgtaag ctgggtactc cgggcagatg ccagcatccg cttgttgaag gccaccaaga    300

tttgtgtgac gggcaaaagc aacttccagt cctacagctg tgtgaggtgc aattacacag    360

aggccttcca gactcagacc agaccctctg gtggtaaatg gacattttcc tacatcggct    420

tccctgtaga gctgaacaca gtctatttca ttggggccca taatattcct aatgcaaata    480

tgaatgaaga tggcccttcc atgtctgtga atttcacctc accaggctgc ctagaccaca    540

taatgaaata taaaaaaaag tgtgtcaagg ccggaagcct gtgggatccg aacatcactg    600

cttgtaagaa gaatgaggag acagtagaag tgaacttcac aaccactccc ctgggaaaca    660

gatacatggc tcttatccaa cacagcacta tcatcgggtt ttctcaggtg tttgagccac    720

accagaagaa acaaacgcga gcttcagtgg tgattccagt gactggggat agtgaaggtg    780

ctacggtgca ggtaaagttc agtgagctgc tctggggagg gaagggacat agaagactgt    840

tccatcattc attgctttta aggatgagtt ctctcttgtc aaatgcactt ctgccagcag    900

acaccagtta agtggcgttc atgggggctc tttcgctgca gcctccaccg tgctgaggtc    960

aggaggccga cgtggcagtt gtggtccctt ttgcttgtat taatggctgc tgaccttcca   1020

aagcactttt tattttcatt ttctgtcaca gacactcagg gatagcagta ccattttact   1080

tccgcaagcc tttaactgca agatgaagct gcaaagggtt tgaaatggga aggtttgagt   1140

tccaggcagc gtatgaactc tggagagggg ctgccagtcc tctctgggcc gcagcggacc   1200

cagctggaac acaggaagtt ggagcagtag gtgctccttc acctctcagt atgtctcttt   1260

caactctagt ttttgaggtg gggacacagg aggtccagtg ggacacagcc actccccaaa   1320

gagtaaggag cttccatgct tcattccctg gcataaaaag tgctcaaaca caccagaggg   1380

ggcaggcacc agccagggta tgatggctac tacccttttc tggagaacca tagacttccc   1440

ttactacagg gacttgcatg tcctaaagca ctggctgaag gaagccaaga ggatcactgc   1500

tgctcctttt ttctagagga aatgtttgtc tacgtggtaa gatatgacct agccctttta   1560

ggtaagcgaa ctggtatgtt agtaacgtgt acaaagttta ggttcagacc ccgggagtct   1620

tgggcacgtg ggtctcgggt cactggtttt gactttaggg ctttgttaca gatgtgtgac   1680

caaggggaaa atgtgcatga caacactaga ggtatgggcg aagccagaaa gaagggaagt   1740

tttggctgaa gtaggagtct tggtgagatt ttgctctgat gcatggtgtg aactttctga   1800

gcctcttgtt tttcctcagc tgactccata ttttcctact tgtggcagcg actgcatccg   1860

acataaagga acagttgtgc tctgcccaca aacaggcgtc cctttccctc tggataacaa   1920

caaaagcaag ccgggaggct ggctgcctct cctcctgctg tctctgctgg tggccacatg   1980

ggtgctggtg gcagggatct atctaatgtg gaggcacgaa aggatcaaga agacttcctt   2040

ttctaccacc acactactgc cccccattaa ggttcttgtg gtttacccat ctgaaatatg   2100

tttccatcac acaatttgtt acttcactga atttcttcaa aaccattgca gaagtgaggt   2160

catccttgaa aagtggcaga aaaagaaaat agcagagatg ggtccagtgc agtggcttgc   2220

cactcaaaag aaggcagcag acaaagtcgt cttccttctt tccaatgacg tcaacagtgt   2280

gtgcgatggt acctgtggca agagcgaggg cagtcccagt gagaactctc aagacctctt   2340

cccccttgcc tttaaccttt tctgcagtga tctaagaagc cagattcatc tgcacaaata   2400

cgtggtggtc tactttagag agattgatac aaaagacgat tacaatgctc tcagtgtctg   2460

ccccaagtac cacctcatga aggatgccac tgctttctgt gcagaacttc tccatgtcaa   2520

gcagcaggtg tcagcaggaa aaagatcaca agcctgccac gatggctgct gctccttgta   2580

gcccacccat gagaagcaag agaccttaaa ggcttcctat cccaccaatt acagggaaaa   2640

aacgtgtgat gatcctgaag cttactatgc agcctacaaa cagccttagt aattaaaaca   2700

ttttatacca ataaaatttt caaatattgc taactaatgt agcattaact aacgattgga   2760

aactacattt acaacttcaa agctgtttta tacatagaaa tcaattacag ttttaattga   2820

aaactataac cattttgata atgcaacaat aaagcatctt cagccaaaca tctagtcttc   2880

catagaccat gcattgcagt gtacccagaa ctgtttagct aatattctat gtttaattaa   2940

tgaatactaa ctctaagaac ccctcactga ttcactcaat agcatcttaa gtgaaaaacc   3000

ttctattaca tgcaaaaaat cattgttttt aagataacaa aagtagggaa taaacaagct   3060

gaacccactt tt                                                       3072


<210>  9342
<211>  296
<212>  PRT
<213>  Homosapiens

<400>  9342

Met Cys Met Thr Thr Leu Glu Val Trp Ala Lys Pro Glu Arg Arg Glu 
1               5                   10                  15      


Val Leu Ala Glu Val Gly Val Leu Val Arg Phe Cys Ser Asp Ala Trp 
            20                  25                  30          


Cys Glu Leu Ser Glu Pro Leu Val Phe Pro Gln Leu Thr Pro Tyr Phe 
        35                  40                  45              


Pro Thr Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu 
    50                  55                  60                  


Cys Pro Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys 
65                  70                  75                  80  


Pro Gly Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr 
                85                  90                  95      


Trp Val Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile 
            100                 105                 110         


Lys Lys Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val 
        115                 120                 125             


Leu Val Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr 
    130                 135                 140                 


Phe Thr Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu 
145                 150                 155                 160 


Lys Trp Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu 
                165                 170                 175     


Ala Thr Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn 
            180                 185                 190         


Asp Val Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser 
        195                 200                 205             


Pro Ser Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe 
    210                 215                 220                 


Cys Ser Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val 
225                 230                 235                 240 


Tyr Phe Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val 
                245                 250                 255     


Cys Pro Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu 
            260                 265                 270         


Leu Leu His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala 
        275                 280                 285             


Cys His Asp Gly Cys Cys Ser Leu 
    290                 295     


<210>  9343
<211>  1567
<212>  DNA
<213>  Homosapiens

<400>  9343
agcgtgcggg tggcctggat cccgcgcagt ggcccggcga tgtcgctcgt gctgctaagc     60

ctggccgcgc tgtgcaggag cgccgtaccc cgagagccga ccgttcaatg tggctctgaa    120

actgtggaca ttttcctaca tcggcttccc tgtagagctg aacacagtct atttcattgg    180

ggcccataat attcctaatg caaatatgaa tgaagatggc ccttccatgt ctgtgaattt    240

cacctcacca ggctgcctag accacataat gaaatataaa aaaaagtgtg tcaaggccgg    300

aagcctgtgg gatccgaaca tcactgcttg taagaagaat gaggagacag tagaagtgaa    360

cttcacaacc actcccctgg gaaacagata catggctctt atccaacaca gcactatcat    420

cgggttttct caggtgtttg agccacacca gaagaaacaa acgcgagctt cagtggtgat    480

tccagtgact ggggatagtg aaggtgctac ggtgcagctg actccatatt ttcctacttg    540

tggcagcgac tgcatccgac ataaaggaac agttgtgctc tgcccacaaa caggcgtccc    600

tttccctctg gataacaaca aaagcaagcc gggaggctgg ctgcctctcc tcctgctgtc    660

tctgctggtg gccacatggg tgctggtggc agggatctat ctaatgtgga ggcacgaaag    720

gatcaagaag acttcctttt ctaccaccac actactgccc cccattaagg ttcttgtggt    780

ttacccatct gaaatatgtt tccatcacac aatttgttac ttcactgaat ttcttcaaaa    840

ccattgcaga agtgaggtca tccttgaaaa gtggcagaaa aagaaaatag cagagatggg    900

tccagtgcag tggcttgcca ctcaaaagaa ggcagcagac aaagtcgtct tccttctttc    960

caatgacgtc aacagtgtgt gcgatggtac ctgtggcaag agcgagggca gtcccagtga   1020

gaactctcaa gacctcttcc cccttgcctt taaccttttc tgcagtgatc taagaagcca   1080

gattcatctg cacaaatacg tggtggtcta ctttagagag attgatacaa aagacgatta   1140

caatgctctc agtgtctgcc ccaagtacca cctcatgaag gatgccactg ctttctgtgc   1200

agaacttctc catgtcaagc agcaggtgtc agcaggaaaa agatcacaag cctgccacga   1260

tggctgctgc tccttgtagc ccacccatga gaagcaagag accttaaagg cttcctatcc   1320

caccaattac agggaaaaaa cgtgtgatga tcctgaagct tactatgcag cctacaaaca   1380

gccttagtaa ttaaaacatt ttataccaat aaaattttca aatattgcta actaatgtag   1440

cattaactaa cgattggaaa ctacatttac aacttcaaag ctgttttata catagaaatc   1500

aattacagtt ttaattgaaa actataacca ttttgataat gcaacaataa agcatcttca   1560

gccaaac                                                             1567


<210>  9344
<211>  357
<212>  PRT
<213>  Homosapiens

<400>  9344

Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro Gly 
1               5                   10                  15      


Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala Gly 
            20                  25                  30          


Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu Thr 
        35                  40                  45              


Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met Ala 
    50                  55                  60                  


Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu Pro 
65                  70                  75                  80  


His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr Gly 
                85                  90                  95      


Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr Cys 
            100                 105                 110         


Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro Gln 
        115                 120                 125             


Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly Gly 
    130                 135                 140                 


Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val Leu 
145                 150                 155                 160 


Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys Thr 
                165                 170                 175     


Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val Val 
            180                 185                 190         


Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr Glu 
        195                 200                 205             


Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp Gln 
    210                 215                 220                 


Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr Gln 
225                 230                 235                 240 


Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val Asn 
                245                 250                 255     


Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser Glu 
            260                 265                 270         


Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser Asp 
        275                 280                 285             


Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe Arg 
    290                 295                 300                 


Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro Lys 
305                 310                 315                 320 


Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu His 
                325                 330                 335     


Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His Asp 
            340                 345                 350         


Gly Cys Cys Ser Leu 
        355         


<210>  9345
<211>  1770
<212>  DNA
<213>  Homosapiens

<400>  9345
agcgtgcggg tggcctggat cccgcgcagt ggcccggcga tgtcgctcgt gctgctaagc     60

ctggccgcgc tgtgcaggag cgccgtaccc cgagagccga ccgttcaatg tggctctgaa    120

actgtggaca ttttcctaca tcggcttccc tgtagagctg aacacagtct atttcattgg    180

ggcccataat attcctaatg caaatatgaa tgaagatggc ccttccatgt ctgtgaattt    240

cacctcacca ggctgcctag accacataat gaaatataaa aaaaagtgtg tcaaggccgg    300

aagcctgtgg gatccgaaca tcactgcttg taagaagaat gaggagacag tagaagtgaa    360

cttcacaacc actcccctgg gaaacagata catggctctt atccaacaca gcactatcat    420

cgggttttct caggtgtttg agccacacca gaagaaacaa acgcgagctt cagtggtgat    480

tccagtgact ggggatagtg aaggtgctac ggtgcagctg actccatatt ttcctacttg    540

tggcagcgac tgcatccgac ataaaggaac agttgtgctc tgcccacaaa caggcgtccc    600

tttccctctg gataacaaca aaagcaagcc gggaggctgg ctgcctctcc tcctgctgtc    660

tctgctggtg gccacatggg tgctggtggc agggatctat ctaatgtgga ggcacgaaag    720

gatcaagaag acttcctttt ctaccaccac actactgccc cccattaagg ttcttgtggt    780

ttacccatct gaaatatgtt tccatcacac aatttgttac ttcactgaat ttcttcaaaa    840

ccattgcaga agtgaggtca tccttgaaaa gtggcagaaa aagaaaatag cagagatggg    900

tccagtgcag tggcttgcca ctcaaaagaa ggcagcagac aaagtcgtct tccttctttc    960

caatgacgtc aacagtgtgt gcgatggtac ctgtggcaag agcgagggca gtcccagtga   1020

gaactctcaa gacctcttcc cccttgcctt taaccttttc tgcagtgatc taagaagcca   1080

gattcatctg cacaaatacg tggtggtcta ctttagagag attgatacaa aagacgatta   1140

caatgctctc agtgtctgcc ccaagtacca cctcatgaag gatgccactg ctttctgtgc   1200

agaacttctc catgtcaagc agcaggtgtc agcaggaaaa agatcacaag cctgccacga   1260

tggctgctgc tccttgtagc ccacccatga gaagcaagag accttaaagg cttcctatcc   1320

caccaattac agggaaaaaa cgtgtgatga tcctgaagct tactatgcag cctacaaaca   1380

gccttagtaa ttaaaacatt ttataccaat aaaattttca aatattgcta actaatgtag   1440

cattaactaa cgattggaaa ctacatttac aacttcaaag ctgttttata catagaaatc   1500

aattacagtt ttaattgaaa actataacca ttttgataat gcaacaataa agcatcttca   1560

gccaaacatc tagtcttcca tagaccatgc attgcagtgt acccagaact gtttagctaa   1620

tattctatgt ttaattaatg aatactaact ctaagaaccc ctcactgatt cactcaatag   1680

catcttaagt gaaaaacctt ctattacatg caaaaaatca ttgtttttaa gataacaaaa   1740

gtagggaata aacaagctga acccactttt                                    1770


<210>  9346
<211>  357
<212>  PRT
<213>  Homosapiens

<400>  9346

Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro Gly 
1               5                   10                  15      


Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala Gly 
            20                  25                  30          


Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu Thr 
        35                  40                  45              


Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met Ala 
    50                  55                  60                  


Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu Pro 
65                  70                  75                  80  


His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr Gly 
                85                  90                  95      


Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr Cys 
            100                 105                 110         


Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro Gln 
        115                 120                 125             


Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly Gly 
    130                 135                 140                 


Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val Leu 
145                 150                 155                 160 


Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys Thr 
                165                 170                 175     


Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val Val 
            180                 185                 190         


Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr Glu 
        195                 200                 205             


Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp Gln 
    210                 215                 220                 


Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr Gln 
225                 230                 235                 240 


Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val Asn 
                245                 250                 255     


Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser Glu 
            260                 265                 270         


Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser Asp 
        275                 280                 285             


Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe Arg 
    290                 295                 300                 


Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro Lys 
305                 310                 315                 320 


Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu His 
                325                 330                 335     


Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His Asp 
            340                 345                 350         


Gly Cys Cys Ser Leu 
        355         


<210>  9347
<211>  2188
<212>  DNA
<213>  Homosapiens

<400>  9347
agcgtgcggg tggcctggat cccgcgcagt ggcccggcga tgtcgctcgt gctgctaagc     60

ctggccgcgc tgtgcaggag cgccgtaccc cgagagccga ccgttcaatg tggctctgaa    120

actgtggaca ttttcctaca tcggcttccc tgtagagctg aacacagtct atttcattgg    180

ggcccataat attcctaatg caaatatgaa tgaagatggc ccttccatgt ctgtgaattt    240

cacctcacca ggctgcctag accacataat gaaatataaa aaaaagtgtg tcaaggccgg    300

aagcctgtgg gatccgaaca tcactgcttg taagaagaat gaggagacag tagaagtgaa    360

cttcacaacc actcccctgg gaaacagata catggctctt atccaacaca gcactatcat    420

cgggttttct caggtgtttg agccacacca gaagaaacaa acgcgagctt cagtggtgat    480

tccagtgact ggggatagtg aaggtgctac ggtgcagctg actccatatt ttcctacttg    540

tggcagcgac tgcatccgac ataaaggaac agttgtgctc tgcccacaaa caggcgtccc    600

tttccctctg gataacaaca aaagcaagcc gggaggctgg ctgcctctcc tcctgctgtc    660

tctgctggtg gccacatggg tgctggtggc agggatctat ctaatgtgga ggcacgaaag    720

gatcaagaag acttcctttt ctaccaccac actactgccc cccattaagg ttcttgtggt    780

ttacccatct gaaatatgtt tccatcacac aatttgttac ttcactgaat ttcttcaaaa    840

ccattgcaga agtgaggtca tccttgaaaa gtggcagaaa aagaaaatag cagagatggg    900

tccagtgcag tggcttgcca ctcaaaagaa ggcagcagac aaagtcgtct tccttctttc    960

caatgacgtc aacagtgtgt gcgatggtac ctgtggcaag agcgagggca gtcccagtga   1020

gaactctcaa gacctcttcc cccttgcctt taaccttttc tgcagtgatc taagaagcca   1080

gattcatctg cacaaatacg tggtggtcta ctttagagag attgatacaa aagacgatta   1140

caatgctctc agtgtctgcc ccaagtacca cctcatgaag gatgccactg ctttctgtgc   1200

agaacttctc catgtcaagc agcaggtgtc agcaggaaaa agatcacaag cctgccacga   1260

tggctgctgc tccttgtagc ccacccatga gaagcaagag accttaaagg cttcctatcc   1320

caccaattac agggaaaaaa cgtgtgatga tcctgaagct tactatgcag cctacaaaca   1380

gccttagtaa ttaaaacatt ttataccaat aaaattttca aatattgcta actaatgtag   1440

cattaactaa cgattggaaa ctacatttac aacttcaaag ctgttttata catagaaatc   1500

aattacagtt ttaattgaaa actataacca ttttgataat gcaacaataa agcatcttca   1560

gccaaacatc tagtcttcca tagaccatgc attgcagtgt acccagaact gtttagctaa   1620

tattctatgt ttaattaatg aatactaact ctaagaaccc ctcactgatt cactcaatag   1680

catcttaagt gaaaaacctt ctattacatg caaaaaatca ttgtttttaa gataacaaaa   1740

gtagggaata aacaagctga acccactttt actggaccaa atgatctatt atatgtgtaa   1800

ccacttgtat gatttggtat ttgcataaga ccttccctct acaaactaga ttcatatctt   1860

gattcttgta caggtgcctt ttaacatgaa caacaaaata cccacaaact tgtctacttt   1920

tgcctaaagt tacctattag aggtcactgt cagagttctc agtttcttag ttactattta   1980

acttttcatg ttcaaaatga aaataattct taagttgaaa gccctcttga agtaaccttt   2040

ttataaatga gttattataa tggtttactt aaataaaaaa caggggtggg tgcagtggct   2100

catgcctcca atcccagcac tttggcaagg ccaaggcaaa aggatcgctc aagaccaggc   2160

tacgtcacaa agcgagacct ccatctct                                      2188


<210>  9348
<211>  357
<212>  PRT
<213>  Homosapiens

<400>  9348

Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro Gly 
1               5                   10                  15      


Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala Gly 
            20                  25                  30          


Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu Thr 
        35                  40                  45              


Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met Ala 
    50                  55                  60                  


Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu Pro 
65                  70                  75                  80  


His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr Gly 
                85                  90                  95      


Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr Cys 
            100                 105                 110         


Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro Gln 
        115                 120                 125             


Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly Gly 
    130                 135                 140                 


Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val Leu 
145                 150                 155                 160 


Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys Thr 
                165                 170                 175     


Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val Val 
            180                 185                 190         


Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr Glu 
        195                 200                 205             


Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp Gln 
    210                 215                 220                 


Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr Gln 
225                 230                 235                 240 


Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val Asn 
                245                 250                 255     


Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser Glu 
            260                 265                 270         


Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser Asp 
        275                 280                 285             


Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe Arg 
    290                 295                 300                 


Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro Lys 
305                 310                 315                 320 


Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu His 
                325                 330                 335     


Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His Asp 
            340                 345                 350         


Gly Cys Cys Ser Leu 
        355         


<210>  9349
<211>  1819
<212>  DNA
<213>  Homosapiens

<400>  9349
gatcccgcgc agtggcccgg cgatgtcgct cgtgctgcta agcctggccg cgctgtgcag     60

gagcgccgta ccccgagagc cgaccgttca atgtggctct gaaactgggc catctccaga    120

gtggatgcta caacatgatc taatccccgg agacttgagg gacctccgag tagaacctgt    180

tacaactagt gttgcaacag gggactattc aattttgatg aatgtaagct gggtactccg    240

ggcagatgcc agcatccgct tgttgaaggc caccaagatt tgtgtgacgg gcaaaagcaa    300

cttccagtcc tacagctgtg tgaggtgcaa ttacacagag gccttccaga ctcagaccag    360

accctctggt ggtaaatgga cattttccta catcggcttc cctgtagagc tgaacacagt    420

ctatttcatt ggggcccata atattcctaa tgcaaatatg aatgaagatg gcccttccat    480

gtctgtgaat ttcacctcac caggctgcct agaccacata atgaaatata aaaaaaagtg    540

tgtcaaggcc ggaagcctgt gggatccgaa catcactgct tgtaagaaga atgaggagac    600

agtagaagtg aacttcacaa ccactcccct gggaaacaga tacatggctc ttatccaaca    660

cagcactatc atcgggtttt ctcaggtgtt tgagccacac cagaagaaac aaacgcgagc    720

ttcagtggtg attccagtga ctggggatag tgaaggtgct acggtgcagc tgactccata    780

ttttcctact tgtggcagcg actgcatccg acataaagga acagttgtgc tctgcccaca    840

aacaggcgtc cctttccctc tggataacaa caaaagcaag ccgggaggct ggctgcctct    900

cctcctgctg tctctgctgg tggccacatg ggtgctggtg gcagggatct atctaatgtg    960

gaggcacgaa aggatcaaga agacttcctt ttctaccacc acactactgc cccccattaa   1020

ggttcttgtg gtttacccat ctgaaatatg tttccatcac acaatttgtt acttcactga   1080

atttcttcaa aaccattgca gaagtgaggt catccttgaa aagtggcaga aaaagaaaat   1140

agcagagatg ggtccagtgc agtggcttgc cactcaaaag aaggcagcag acaaagtcgt   1200

cttccttctt tccaatgacg tcaacagtgt gtgcgatggt acctgtggca agagcgaggg   1260

cagtcccagt gagaactctc aagacctctt cccccttgcc tttaaccttt tctgcagtga   1320

tctaagaagc cagattcatc tgcacaaata cgtggtggtc tactttagag agattgatac   1380

aaaagacgat tacaatgctc tcagtgtctg ccccaagtac cacctcatga aggatgccac   1440

tgctttctgt gcagaacttc tccatgtcaa gcagcaggtg tcagcaggaa aaagatcaca   1500

agcctgccac gatggctgct gctccttgta gcccacccat gagaagcaag agaccttaaa   1560

ggcttcctat cccaccaatt acagggaaaa aacgtgtgat gatcctgaag cttactatgc   1620

agcctacaaa cagccttagt aattaaaaca ttttatacca ataaaatttt caaatattgc   1680

taactaatgt agcattaact aacgattgga aactacattt acaacttcaa agctgtttta   1740

tacatagaaa tcaattacag ttttaattga aaactataac cattttgata atgcaacaat   1800

aaagcatctt cagccaaac                                                1819


<210>  9350
<211>  502
<212>  PRT
<213>  Homosapiens

<400>  9350

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  9351
<211>  2847
<212>  DNA
<213>  Homosapiens

<400>  9351
gatcccgcgc agtggcccgg cgatgtcgct cgtgctgcta agcctggccg cgctgtgcag     60

gagcgccgta ccccgagagc cgaccgttca atgtggctct gaaactgggc catctccaga    120

gtggatgcta caacatgatc taatccccgg agacttgagg gacctccgag tagaacctgt    180

tacaactagt gttgcaacag gggactattc aattttgatg aatgtaagct gggtactccg    240

ggcagatgcc agcatccgct tgttgaaggc caccaagatt tgtgtgacgg gcaaaagcaa    300

cttccagtcc tacagctgtg tgaggtgcaa ttacacagag gccttccaga ctcagaccag    360

accctctggt ggtaaatgga cattttccta catcggcttc cctgtagagc tgaacacagt    420

ctatttcatt ggggcccata atattcctaa tgcaaatatg aatgaagatg gcccttccat    480

gtctgtgaat ttcacctcac caggctgcct agaccacata atgaaatata aaaaaaagtg    540

tgtcaaggcc ggaagcctgt gggatccgaa catcactgct tgtaagaaga atgaggagac    600

agtagaagtg aacttcacaa ccactcccct gggaaacaga tacatggctc ttatccaaca    660

cagcactatc atcgggtttt ctcaggtgtt tgagccacac cagaagaaac aaacgcgagc    720

ttcagtggtg attccagtga ctggggatag tgaaggtgct acggtgcagg taaagttcag    780

tgagctgctc tggggaggga agggacatag aagactgttc catcattcat tgcttttaag    840

gatgagttct ctcttgtcaa atgcacttct gccagcagac accagttaag tggcgttcat    900

gggggctctt tcgctgcagc ctccaccgtg ctgaggtcag gaggccgacg tggcagttgt    960

ggtccctttt gcttgtatta atggctgctg accttccaaa gcacttttta ttttcatttt   1020

ctgtcacaga cactcaggga tagcagtacc attttacttc cgcaagcctt taactgcaag   1080

atgaagctgc aaagggtttg aaatgggaag gtttgagttc caggcagcgt atgaactctg   1140

gagaggggct gccagtcctc tctgggccgc agcggaccca gctggaacac aggaagttgg   1200

agcagtaggt gctccttcac ctctcagtat gtctctttca actctagttt ttgaggtggg   1260

gacacaggag gtccagtggg acacagccac tccccaaaga gtaaggagct tccatgcttc   1320

attccctggc ataaaaagtg ctcaaacaca ccagaggggg caggcaccag ccagggtatg   1380

atggctacta cccttttctg gagaaccata gacttccctt actacaggga cttgcatgtc   1440

ctaaagcact ggctgaagga agccaagagg atcactgctg ctcctttttt ctagaggaaa   1500

tgtttgtcta cgtggtaaga tatgacctag cccttttagg taagcgaact ggtatgttag   1560

taacgtgtac aaagtttagg ttcagacccc gggagtcttg ggcacgtggg tctcgggtca   1620

ctggttttga ctttagggct ttgttacaga tgtgtgacca aggggaaaat gtgcatgaca   1680

acactagagg tatgggcgaa gccagaaaga agggaagttt tggctgaagt aggagtcttg   1740

gtgagatttt gctctgatgc atggtgtgaa ctttctgagc ctcttgtttt tcctcagctg   1800

actccatatt ttcctacttg tggcagcgac tgcatccgac ataaaggaac agttgtgctc   1860

tgcccacaaa caggcgtccc tttccctctg gataacaaca aaagcaagcc gggaggctgg   1920

ctgcctctcc tcctgctgtc tctgctggtg gccacatggg tgctggtggc agggatctat   1980

ctaatgtgga ggcacgaaag gatcaagaag acttcctttt ctaccaccac actactgccc   2040

cccattaagg ttcttgtggt ttacccatct gaaatatgtt tccatcacac aatttgttac   2100

ttcactgaat ttcttcaaaa ccattgcaga agtgaggtca tccttgaaaa gtggcagaaa   2160

aagaaaatag cagagatggg tccagtgcag tggcttgcca ctcaaaagaa ggcagcagac   2220

aaagtcgtct tccttctttc caatgacgtc aacagtgtgt gcgatggtac ctgtggcaag   2280

agcgagggca gtcccagtga gaactctcaa gacctcttcc cccttgcctt taaccttttc   2340

tgcagtgatc taagaagcca gattcatctg cacaaatacg tggtggtcta ctttagagag   2400

attgatacaa aagacgatta caatgctctc agtgtctgcc ccaagtacca cctcatgaag   2460

gatgccactg ctttctgtgc agaacttctc catgtcaagc agcaggtgtc agcaggaaaa   2520

agatcacaag cctgccacga tggctgctgc tccttgtagc ccacccatga gaagcaagag   2580

accttaaagg cttcctatcc caccaattac agggaaaaaa cgtgtgatga tcctgaagct   2640

tactatgcag cctacaaaca gccttagtaa ttaaaacatt ttataccaat aaaattttca   2700

aatattgcta actaatgtag cattaactaa cgattggaaa ctacatttac aacttcaaag   2760

ctgttttata catagaaatc aattacagtt ttaattgaaa actataacca ttttgataat   2820

gcaacaataa agcatcttca gccaaac                                       2847


<210>  9352
<211>  296
<212>  PRT
<213>  Homosapiens

<400>  9352

Met Cys Met Thr Thr Leu Glu Val Trp Ala Lys Pro Glu Arg Arg Glu 
1               5                   10                  15      


Val Leu Ala Glu Val Gly Val Leu Val Arg Phe Cys Ser Asp Ala Trp 
            20                  25                  30          


Cys Glu Leu Ser Glu Pro Leu Val Phe Pro Gln Leu Thr Pro Tyr Phe 
        35                  40                  45              


Pro Thr Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu 
    50                  55                  60                  


Cys Pro Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys 
65                  70                  75                  80  


Pro Gly Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr 
                85                  90                  95      


Trp Val Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile 
            100                 105                 110         


Lys Lys Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val 
        115                 120                 125             


Leu Val Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr 
    130                 135                 140                 


Phe Thr Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu 
145                 150                 155                 160 


Lys Trp Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu 
                165                 170                 175     


Ala Thr Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn 
            180                 185                 190         


Asp Val Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser 
        195                 200                 205             


Pro Ser Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe 
    210                 215                 220                 


Cys Ser Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val 
225                 230                 235                 240 


Tyr Phe Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val 
                245                 250                 255     


Cys Pro Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu 
            260                 265                 270         


Leu Leu His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala 
        275                 280                 285             


Cys His Asp Gly Cys Cys Ser Leu 
    290                 295     


<210>  9353
<211>  2440
<212>  DNA
<213>  Homosapiens

<400>  9353
gatcccgcgc agtggcccgg cgatgtcgct cgtgctgcta agcctggccg cgctgtgcag     60

gagcgccgta ccccgagagc cgaccgttca atgtggctct gaaactgggc catctccaga    120

gtggatgcta caacatgatc taatccccgg agacttgagg gacctccgag tagaacctgt    180

tacaactagt gttgcaacag gggactattc aattttgatg aatgtaagct gggtactccg    240

ggcagatgcc agcatccgct tgttgaaggc caccaagatt tgtgtgacgg gcaaaagcaa    300

cttccagtcc tacagctgtg tgaggtgcaa ttacacagag gccttccaga ctcagaccag    360

accctctggt ggtaaatgga cattttccta catcggcttc cctgtagagc tgaacacagt    420

ctatttcatt ggggcccata atattcctaa tgcaaatatg aatgaagatg gcccttccat    480

gtctgtgaat ttcacctcac caggctgcct agaccacata atgaaatata aaaaaaagtg    540

tgtcaaggcc ggaagcctgt gggatccgaa catcactgct tgtaagaaga atgaggagac    600

agtagaagtg aacttcacaa ccactcccct gggaaacaga tacatggctc ttatccaaca    660

cagcactatc atcgggtttt ctcaggtgtt tgagccacac cagaagaaac aaacgcgagc    720

ttcagtggtg attccagtga ctggggatag tgaaggtgct acggtgcagc tgactccata    780

ttttcctact tgtggcagcg actgcatccg acataaagga acagttgtgc tctgcccaca    840

aacaggcgtc cctttccctc tggataacaa caaaagcaag ccgggaggct ggctgcctct    900

cctcctgctg tctctgctgg tggccacatg ggtgctggtg gcagggatct atctaatgtg    960

gaggcacgaa aggatcaaga agacttcctt ttctaccacc acactactgc cccccattaa   1020

ggttcttgtg gtttacccat ctgaaatatg tttccatcac acaatttgtt acttcactga   1080

atttcttcaa aaccattgca gaagtgaggt catccttgaa aagtggcaga aaaagaaaat   1140

agcagagatg ggtccagtgc agtggcttgc cactcaaaag aaggcagcag acaaagtcgt   1200

cttccttctt tccaatgacg tcaacagtgt gtgcgatggt acctgtggca agagcgaggg   1260

cagtcccagt gagaactctc aagacctctt cccccttgcc tttaaccttt tctgcagtga   1320

tctaagaagc cagattcatc tgcacaaata cgtggtggtc tactttagag agattgatac   1380

aaaagacgat tacaatgctc tcagtgtctg ccccaagtac cacctcatga aggatgccac   1440

tgctttctgt gcagaacttc tccatgtcaa gcagcaggtg tcagcaggaa aaagatcaca   1500

agcctgccac gatggctgct gctccttgta gcccacccat gagaagcaag agaccttaaa   1560

ggcttcctat cccaccaatt acagggaaaa aacgtgtgat gatcctgaag cttactatgc   1620

agcctacaaa cagccttagt aattaaaaca ttttatacca ataaaatttt caaatattgc   1680

taactaatgt agcattaact aacgattgga aactacattt acaacttcaa agctgtttta   1740

tacatagaaa tcaattacag ttttaattga aaactataac cattttgata atgcaacaat   1800

aaagcatctt cagccaaaca tctagtcttc catagaccat gcattgcagt gtacccagaa   1860

ctgtttagct aatattctat gtttaattaa tgaatactaa ctctaagaac ccctcactga   1920

ttcactcaat agcatcttaa gtgaaaaacc ttctattaca tgcaaaaaat cattgttttt   1980

aagataacaa aagtagggaa taaacaagct gaacccactt ttactggacc aaatgatcta   2040

ttatatgtgt aaccacttgt atgatttggt atttgcataa gaccttccct ctacaaacta   2100

gattcatatc ttgattcttg tacaggtgcc ttttaacatg aacaacaaaa tacccacaaa   2160

cttgtctact tttgcctaaa gttacctatt agaggtcact gtcagagttc tcagtttctt   2220

agttactatt taacttttca tgttcaaaat gaaaataatt cttaagttga aagccctctt   2280

gaagtaacct ttttataaat gagttattat aatggtttac ttaaataaaa aacaggggtg   2340

ggtgcagtgg ctcatgcctc caatcccagc actttggcaa ggccaaggca aaaggatcgc   2400

tcaagaccag gctacgtcac aaagcgagac ctccatctct                         2440


<210>  9354
<211>  502
<212>  PRT
<213>  Homosapiens

<400>  9354

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  9355
<211>  3468
<212>  DNA
<213>  Homosapiens

<400>  9355
gatcccgcgc agtggcccgg cgatgtcgct cgtgctgcta agcctggccg cgctgtgcag     60

gagcgccgta ccccgagagc cgaccgttca atgtggctct gaaactgggc catctccaga    120

gtggatgcta caacatgatc taatccccgg agacttgagg gacctccgag tagaacctgt    180

tacaactagt gttgcaacag gggactattc aattttgatg aatgtaagct gggtactccg    240

ggcagatgcc agcatccgct tgttgaaggc caccaagatt tgtgtgacgg gcaaaagcaa    300

cttccagtcc tacagctgtg tgaggtgcaa ttacacagag gccttccaga ctcagaccag    360

accctctggt ggtaaatgga cattttccta catcggcttc cctgtagagc tgaacacagt    420

ctatttcatt ggggcccata atattcctaa tgcaaatatg aatgaagatg gcccttccat    480

gtctgtgaat ttcacctcac caggctgcct agaccacata atgaaatata aaaaaaagtg    540

tgtcaaggcc ggaagcctgt gggatccgaa catcactgct tgtaagaaga atgaggagac    600

agtagaagtg aacttcacaa ccactcccct gggaaacaga tacatggctc ttatccaaca    660

cagcactatc atcgggtttt ctcaggtgtt tgagccacac cagaagaaac aaacgcgagc    720

ttcagtggtg attccagtga ctggggatag tgaaggtgct acggtgcagg taaagttcag    780

tgagctgctc tggggaggga agggacatag aagactgttc catcattcat tgcttttaag    840

gatgagttct ctcttgtcaa atgcacttct gccagcagac accagttaag tggcgttcat    900

gggggctctt tcgctgcagc ctccaccgtg ctgaggtcag gaggccgacg tggcagttgt    960

ggtccctttt gcttgtatta atggctgctg accttccaaa gcacttttta ttttcatttt   1020

ctgtcacaga cactcaggga tagcagtacc attttacttc cgcaagcctt taactgcaag   1080

atgaagctgc aaagggtttg aaatgggaag gtttgagttc caggcagcgt atgaactctg   1140

gagaggggct gccagtcctc tctgggccgc agcggaccca gctggaacac aggaagttgg   1200

agcagtaggt gctccttcac ctctcagtat gtctctttca actctagttt ttgaggtggg   1260

gacacaggag gtccagtggg acacagccac tccccaaaga gtaaggagct tccatgcttc   1320

attccctggc ataaaaagtg ctcaaacaca ccagaggggg caggcaccag ccagggtatg   1380

atggctacta cccttttctg gagaaccata gacttccctt actacaggga cttgcatgtc   1440

ctaaagcact ggctgaagga agccaagagg atcactgctg ctcctttttt ctagaggaaa   1500

tgtttgtcta cgtggtaaga tatgacctag cccttttagg taagcgaact ggtatgttag   1560

taacgtgtac aaagtttagg ttcagacccc gggagtcttg ggcacgtggg tctcgggtca   1620

ctggttttga ctttagggct ttgttacaga tgtgtgacca aggggaaaat gtgcatgaca   1680

acactagagg tatgggcgaa gccagaaaga agggaagttt tggctgaagt aggagtcttg   1740

gtgagatttt gctctgatgc atggtgtgaa ctttctgagc ctcttgtttt tcctcagctg   1800

actccatatt ttcctacttg tggcagcgac tgcatccgac ataaaggaac agttgtgctc   1860

tgcccacaaa caggcgtccc tttccctctg gataacaaca aaagcaagcc gggaggctgg   1920

ctgcctctcc tcctgctgtc tctgctggtg gccacatggg tgctggtggc agggatctat   1980

ctaatgtgga ggcacgaaag gatcaagaag acttcctttt ctaccaccac actactgccc   2040

cccattaagg ttcttgtggt ttacccatct gaaatatgtt tccatcacac aatttgttac   2100

ttcactgaat ttcttcaaaa ccattgcaga agtgaggtca tccttgaaaa gtggcagaaa   2160

aagaaaatag cagagatggg tccagtgcag tggcttgcca ctcaaaagaa ggcagcagac   2220

aaagtcgtct tccttctttc caatgacgtc aacagtgtgt gcgatggtac ctgtggcaag   2280

agcgagggca gtcccagtga gaactctcaa gacctcttcc cccttgcctt taaccttttc   2340

tgcagtgatc taagaagcca gattcatctg cacaaatacg tggtggtcta ctttagagag   2400

attgatacaa aagacgatta caatgctctc agtgtctgcc ccaagtacca cctcatgaag   2460

gatgccactg ctttctgtgc agaacttctc catgtcaagc agcaggtgtc agcaggaaaa   2520

agatcacaag cctgccacga tggctgctgc tccttgtagc ccacccatga gaagcaagag   2580

accttaaagg cttcctatcc caccaattac agggaaaaaa cgtgtgatga tcctgaagct   2640

tactatgcag cctacaaaca gccttagtaa ttaaaacatt ttataccaat aaaattttca   2700

aatattgcta actaatgtag cattaactaa cgattggaaa ctacatttac aacttcaaag   2760

ctgttttata catagaaatc aattacagtt ttaattgaaa actataacca ttttgataat   2820

gcaacaataa agcatcttca gccaaacatc tagtcttcca tagaccatgc attgcagtgt   2880

acccagaact gtttagctaa tattctatgt ttaattaatg aatactaact ctaagaaccc   2940

ctcactgatt cactcaatag catcttaagt gaaaaacctt ctattacatg caaaaaatca   3000

ttgtttttaa gataacaaaa gtagggaata aacaagctga acccactttt actggaccaa   3060

atgatctatt atatgtgtaa ccacttgtat gatttggtat ttgcataaga ccttccctct   3120

acaaactaga ttcatatctt gattcttgta caggtgcctt ttaacatgaa caacaaaata   3180

cccacaaact tgtctacttt tgcctaaagt tacctattag aggtcactgt cagagttctc   3240

agtttcttag ttactattta acttttcatg ttcaaaatga aaataattct taagttgaaa   3300

gccctcttga agtaaccttt ttataaatga gttattataa tggtttactt aaataaaaaa   3360

caggggtggg tgcagtggct catgcctcca atcccagcac tttggcaagg ccaaggcaaa   3420

aggatcgctc aagaccaggc tacgtcacaa agcgagacct ccatctct                3468


<210>  9356
<211>  296
<212>  PRT
<213>  Homosapiens

<400>  9356

Met Cys Met Thr Thr Leu Glu Val Trp Ala Lys Pro Glu Arg Arg Glu 
1               5                   10                  15      


Val Leu Ala Glu Val Gly Val Leu Val Arg Phe Cys Ser Asp Ala Trp 
            20                  25                  30          


Cys Glu Leu Ser Glu Pro Leu Val Phe Pro Gln Leu Thr Pro Tyr Phe 
        35                  40                  45              


Pro Thr Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu 
    50                  55                  60                  


Cys Pro Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys 
65                  70                  75                  80  


Pro Gly Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr 
                85                  90                  95      


Trp Val Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile 
            100                 105                 110         


Lys Lys Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val 
        115                 120                 125             


Leu Val Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr 
    130                 135                 140                 


Phe Thr Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu 
145                 150                 155                 160 


Lys Trp Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu 
                165                 170                 175     


Ala Thr Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn 
            180                 185                 190         


Asp Val Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser 
        195                 200                 205             


Pro Ser Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe 
    210                 215                 220                 


Cys Ser Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val 
225                 230                 235                 240 


Tyr Phe Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val 
                245                 250                 255     


Cys Pro Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu 
            260                 265                 270         


Leu Leu His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala 
        275                 280                 285             


Cys His Asp Gly Cys Cys Ser Leu 
    290                 295     


<210>  9357
<211>  1295
<212>  DNA
<213>  Homosapiens

<400>  9357
agcactggct gaaggaagcc aagaggatca ctgctgctcc ttttttctag aggaaatgtt     60

tgtctacgtg gtaagatatg acctagccct tttaggtaag cgaactggta tgttagtaac    120

gtgtacaaag tttaggttca gaccccggga gtcttgggca cgtgggtctc gggtcactgg    180

ttttgacttt agggctttgt tacagatgtg tgaccaaggg gaaaatgtgc atgacaacac    240

tagagctgac tccatatttt cctacttgtg gcagcgactg catccgacat aaaggaacag    300

ttgtgctctg cccacaaaca ggcgtccctt tccctctgga taacaacaaa agcaagccgg    360

gaggctggct gcctctcctc ctgctgtctc tgctggtggc cacatgggtg ctggtggcag    420

ggatctatct aatgtggagg cacgaaagga tcaagaagac ttccttttct accaccacac    480

tactgccccc cattaaggtt cttgtggttt acccatctga aatatgtttc catcacacaa    540

tttgttactt cactgaattt cttcaaaacc attgcagaag tgaggtcatc cttgaaaagt    600

ggcagaaaaa gaaaatagca gagatgggtc cagtgcagtg gcttgccact caaaagaagg    660

cagcagacaa agtcgtcttc cttctttcca atgacgtcaa cagtgtgtgc gatggtacct    720

gtggcaagag cgagggcagt cccagtgaga actctcaaga cctcttcccc cttgccttta    780

accttttctg cagtgatcta agaagccaga ttcatctgca caaatacgtg gtggtctact    840

ttagagagat tgatacaaaa gacgattaca atgctctcag tgtctgcccc aagtaccacc    900

tcatgaagga tgccactgct ttctgtgcag aacttctcca tgtcaagcag caggtgtcag    960

caggaaaaag atcacaagcc tgccacgatg gctgctgctc cttgtagccc acccatgaga   1020

agcaagagac cttaaaggct tcctatccca ccaattacag ggaaaaaacg tgtgatgatc   1080

ctgaagctta ctatgcagcc tacaaacagc cttagtaatt aaaacatttt ataccaataa   1140

aattttcaaa tattgctaac taatgtagca ttaactaacg attggaaact acatttacaa   1200

cttcaaagct gttttataca tagaaatcaa ttacagtttt aattgaaaac tataaccatt   1260

ttgataatgc aacaataaag catcttcagc caaac                              1295


<210>  9358
<211>  260
<212>  PRT
<213>  Homosapiens

<400>  9358

Met Cys Met Thr Thr Leu Glu Leu Thr Pro Tyr Phe Pro Thr Cys Gly 
1               5                   10                  15      


Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro Gln Thr 
            20                  25                  30          


Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly Gly Trp 
        35                  40                  45              


Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val Leu Val 
    50                  55                  60                  


Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys Thr Ser 
65                  70                  75                  80  


Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val Val Tyr 
                85                  90                  95      


Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr Glu Phe 
            100                 105                 110         


Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp Gln Lys 
        115                 120                 125             


Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr Gln Lys 
    130                 135                 140                 


Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val Asn Ser 
145                 150                 155                 160 


Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser Glu Asn 
                165                 170                 175     


Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser Asp Leu 
            180                 185                 190         


Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe Arg Glu 
        195                 200                 205             


Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro Lys Tyr 
    210                 215                 220                 


His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu His Val 
225                 230                 235                 240 


Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His Asp Gly 
                245                 250                 255     


Cys Cys Ser Leu 
            260 


<210>  9359
<211>  1498
<212>  DNA
<213>  Homosapiens

<400>  9359
agcactggct gaaggaagcc aagaggatca ctgctgctcc ttttttctag aggaaatgtt     60

tgtctacgtg gtaagatatg acctagccct tttaggtaag cgaactggta tgttagtaac    120

gtgtacaaag tttaggttca gaccccggga gtcttgggca cgtgggtctc gggtcactgg    180

ttttgacttt agggctttgt tacagatgtg tgaccaaggg gaaaatgtgc atgacaacac    240

tagagctgac tccatatttt cctacttgtg gcagcgactg catccgacat aaaggaacag    300

ttgtgctctg cccacaaaca ggcgtccctt tccctctgga taacaacaaa agcaagccgg    360

gaggctggct gcctctcctc ctgctgtctc tgctggtggc cacatgggtg ctggtggcag    420

ggatctatct aatgtggagg cacgaaagga tcaagaagac ttccttttct accaccacac    480

tactgccccc cattaaggtt cttgtggttt acccatctga aatatgtttc catcacacaa    540

tttgttactt cactgaattt cttcaaaacc attgcagaag tgaggtcatc cttgaaaagt    600

ggcagaaaaa gaaaatagca gagatgggtc cagtgcagtg gcttgccact caaaagaagg    660

cagcagacaa agtcgtcttc cttctttcca atgacgtcaa cagtgtgtgc gatggtacct    720

gtggcaagag cgagggcagt cccagtgaga actctcaaga cctcttcccc cttgccttta    780

accttttctg cagtgatcta agaagccaga ttcatctgca caaatacgtg gtggtctact    840

ttagagagat tgatacaaaa gacgattaca atgctctcag tgtctgcccc aagtaccacc    900

tcatgaagga tgccactgct ttctgtgcag aacttctcca tgtcaagcag caggtgtcag    960

caggaaaaag atcacaagcc tgccacgatg gctgctgctc cttgtagccc acccatgaga   1020

agcaagagac cttaaaggct tcctatccca ccaattacag ggaaaaaacg tgtgatgatc   1080

ctgaagctta ctatgcagcc tacaaacagc cttagtaatt aaaacatttt ataccaataa   1140

aattttcaaa tattgctaac taatgtagca ttaactaacg attggaaact acatttacaa   1200

cttcaaagct gttttataca tagaaatcaa ttacagtttt aattgaaaac tataaccatt   1260

ttgataatgc aacaataaag catcttcagc caaacatcta gtcttccata gaccatgcat   1320

tgcagtgtac ccagaactgt ttagctaata ttctatgttt aattaatgaa tactaactct   1380

aagaacccct cactgattca ctcaatagca tcttaagtga aaaaccttct attacatgca   1440

aaaaatcatt gtttttaaga taacaaaagt agggaataaa caagctgaac ccactttt     1498


<210>  9360
<211>  260
<212>  PRT
<213>  Homosapiens

<400>  9360

Met Cys Met Thr Thr Leu Glu Leu Thr Pro Tyr Phe Pro Thr Cys Gly 
1               5                   10                  15      


Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro Gln Thr 
            20                  25                  30          


Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly Gly Trp 
        35                  40                  45              


Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val Leu Val 
    50                  55                  60                  


Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys Thr Ser 
65                  70                  75                  80  


Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val Val Tyr 
                85                  90                  95      


Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr Glu Phe 
            100                 105                 110         


Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp Gln Lys 
        115                 120                 125             


Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr Gln Lys 
    130                 135                 140                 


Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val Asn Ser 
145                 150                 155                 160 


Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser Glu Asn 
                165                 170                 175     


Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser Asp Leu 
            180                 185                 190         


Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe Arg Glu 
        195                 200                 205             


Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro Lys Tyr 
    210                 215                 220                 


His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu His Val 
225                 230                 235                 240 


Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His Asp Gly 
                245                 250                 255     


Cys Cys Ser Leu 
            260 


<210>  9361
<211>  1916
<212>  DNA
<213>  Homosapiens

<400>  9361
agcactggct gaaggaagcc aagaggatca ctgctgctcc ttttttctag aggaaatgtt     60

tgtctacgtg gtaagatatg acctagccct tttaggtaag cgaactggta tgttagtaac    120

gtgtacaaag tttaggttca gaccccggga gtcttgggca cgtgggtctc gggtcactgg    180

ttttgacttt agggctttgt tacagatgtg tgaccaaggg gaaaatgtgc atgacaacac    240

tagagctgac tccatatttt cctacttgtg gcagcgactg catccgacat aaaggaacag    300

ttgtgctctg cccacaaaca ggcgtccctt tccctctgga taacaacaaa agcaagccgg    360

gaggctggct gcctctcctc ctgctgtctc tgctggtggc cacatgggtg ctggtggcag    420

ggatctatct aatgtggagg cacgaaagga tcaagaagac ttccttttct accaccacac    480

tactgccccc cattaaggtt cttgtggttt acccatctga aatatgtttc catcacacaa    540

tttgttactt cactgaattt cttcaaaacc attgcagaag tgaggtcatc cttgaaaagt    600

ggcagaaaaa gaaaatagca gagatgggtc cagtgcagtg gcttgccact caaaagaagg    660

cagcagacaa agtcgtcttc cttctttcca atgacgtcaa cagtgtgtgc gatggtacct    720

gtggcaagag cgagggcagt cccagtgaga actctcaaga cctcttcccc cttgccttta    780

accttttctg cagtgatcta agaagccaga ttcatctgca caaatacgtg gtggtctact    840

ttagagagat tgatacaaaa gacgattaca atgctctcag tgtctgcccc aagtaccacc    900

tcatgaagga tgccactgct ttctgtgcag aacttctcca tgtcaagcag caggtgtcag    960

caggaaaaag atcacaagcc tgccacgatg gctgctgctc cttgtagccc acccatgaga   1020

agcaagagac cttaaaggct tcctatccca ccaattacag ggaaaaaacg tgtgatgatc   1080

ctgaagctta ctatgcagcc tacaaacagc cttagtaatt aaaacatttt ataccaataa   1140

aattttcaaa tattgctaac taatgtagca ttaactaacg attggaaact acatttacaa   1200

cttcaaagct gttttataca tagaaatcaa ttacagtttt aattgaaaac tataaccatt   1260

ttgataatgc aacaataaag catcttcagc caaacatcta gtcttccata gaccatgcat   1320

tgcagtgtac ccagaactgt ttagctaata ttctatgttt aattaatgaa tactaactct   1380

aagaacccct cactgattca ctcaatagca tcttaagtga aaaaccttct attacatgca   1440

aaaaatcatt gtttttaaga taacaaaagt agggaataaa caagctgaac ccacttttac   1500

tggaccaaat gatctattat atgtgtaacc acttgtatga tttggtattt gcataagacc   1560

ttccctctac aaactagatt catatcttga ttcttgtaca ggtgcctttt aacatgaaca   1620

acaaaatacc cacaaacttg tctacttttg cctaaagtta cctattagag gtcactgtca   1680

gagttctcag tttcttagtt actatttaac ttttcatgtt caaaatgaaa ataattctta   1740

agttgaaagc cctcttgaag taaccttttt ataaatgagt tattataatg gtttacttaa   1800

ataaaaaaca ggggtgggtg cagtggctca tgcctccaat cccagcactt tggcaaggcc   1860

aaggcaaaag gatcgctcaa gaccaggcta cgtcacaaag cgagacctcc atctct       1916


<210>  9362
<211>  260
<212>  PRT
<213>  Homosapiens

<400>  9362

Met Cys Met Thr Thr Leu Glu Leu Thr Pro Tyr Phe Pro Thr Cys Gly 
1               5                   10                  15      


Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro Gln Thr 
            20                  25                  30          


Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly Gly Trp 
        35                  40                  45              


Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val Leu Val 
    50                  55                  60                  


Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys Thr Ser 
65                  70                  75                  80  


Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val Val Tyr 
                85                  90                  95      


Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr Glu Phe 
            100                 105                 110         


Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp Gln Lys 
        115                 120                 125             


Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr Gln Lys 
    130                 135                 140                 


Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val Asn Ser 
145                 150                 155                 160 


Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser Glu Asn 
                165                 170                 175     


Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser Asp Leu 
            180                 185                 190         


Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe Arg Glu 
        195                 200                 205             


Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro Lys Tyr 
    210                 215                 220                 


His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu His Val 
225                 230                 235                 240 


Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His Asp Gly 
                245                 250                 255     


Cys Cys Ser Leu 
            260 


<210>  9363
<211>  1255
<212>  DNA
<213>  Homosapiens

<400>  9363
tctacgtggt aagatatgac ctagcccttt taggtaagcg aactggtatg ttagtaacgt     60

gtacaaagtt taggttcaga ccccgggagt cttgggcacg tgggtctcgg gtcactggtt    120

ttgactttag ggctttgtta cagatgtgtg accaagggga aaatgtgcat gacaacacta    180

gaggtatggg cgaagccaga aagaagggaa gttttggctg aagtaggagt cttgcgactg    240

catccgacat aaaggaacag ttgtgctctg cccacaaaca ggcgtccctt tccctctgga    300

taacaacaaa agcaagccgg gaggctggct gcctctcctc ctgctgtctc tgctggtggc    360

cacatgggtg ctggtggcag ggatctatct aatgtggagg cacgaaagga tcaagaagac    420

ttccttttct accaccacac tactgccccc cattaaggtt cttgtggttt acccatctga    480

aatatgtttc catcacacaa tttgttactt cactgaattt cttcaaaacc attgcagaag    540

tgaggtcatc cttgaaaagt ggcagaaaaa gaaaatagca gagatgggtc cagtgcagtg    600

gcttgccact caaaagaagg cagcagacaa agtcgtcttc cttctttcca atgacgtcaa    660

cagtgtgtgc gatggtacct gtggcaagag cgagggcagt cccagtgaga actctcaaga    720

cctcttcccc cttgccttta accttttctg cagtgatcta agaagccaga ttcatctgca    780

caaatacgtg gtggtctact ttagagagat tgatacaaaa gacgattaca atgctctcag    840

tgtctgcccc aagtaccacc tcatgaagga tgccactgct ttctgtgcag aacttctcca    900

tgtcaagcag caggtgtcag caggaaaaag atcacaagcc tgccacgatg gctgctgctc    960

cttgtagccc acccatgaga agcaagagac cttaaaggct tcctatccca ccaattacag   1020

ggaaaaaacg tgtgatgatc ctgaagctta ctatgcagcc tacaaacagc cttagtaatt   1080

aaaacatttt ataccaataa aattttcaaa tattgctaac taatgtagca ttaactaacg   1140

attggaaact acatttacaa cttcaaagct gttttataca tagaaatcaa ttacagtttt   1200

aattgaaaac tataaccatt ttgataatgc aacaataaag catcttcagc caaac        1255


<210>  9364
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  9364

Met Trp Arg His Glu Arg Ile Lys Lys Thr Ser Phe Ser Thr Thr Thr 
1               5                   10                  15      


Leu Leu Pro Pro Ile Lys Val Leu Val Val Tyr Pro Ser Glu Ile Cys 
            20                  25                  30          


Phe His His Thr Ile Cys Tyr Phe Thr Glu Phe Leu Gln Asn His Cys 
        35                  40                  45              


Arg Ser Glu Val Ile Leu Glu Lys Trp Gln Lys Lys Lys Ile Ala Glu 
    50                  55                  60                  


Met Gly Pro Val Gln Trp Leu Ala Thr Gln Lys Lys Ala Ala Asp Lys 
65                  70                  75                  80  


Val Val Phe Leu Leu Ser Asn Asp Val Asn Ser Val Cys Asp Gly Thr 
                85                  90                  95      


Cys Gly Lys Ser Glu Gly Ser Pro Ser Glu Asn Ser Gln Asp Leu Phe 
            100                 105                 110         


Pro Leu Ala Phe Asn Leu Phe Cys Ser Asp Leu Arg Ser Gln Ile His 
        115                 120                 125             


Leu His Lys Tyr Val Val Val Tyr Phe Arg Glu Ile Asp Thr Lys Asp 
    130                 135                 140                 


Asp Tyr Asn Ala Leu Ser Val Cys Pro Lys Tyr His Leu Met Lys Asp 
145                 150                 155                 160 


Ala Thr Ala Phe Cys Ala Glu Leu Leu His Val Lys Gln Gln Val Ser 
                165                 170                 175     


Ala Gly Lys Arg Ser Gln Ala Cys His Asp Gly Cys Cys Ser Leu 
            180                 185                 190     


<210>  9365
<211>  1458
<212>  DNA
<213>  Homosapiens

<400>  9365
tctacgtggt aagatatgac ctagcccttt taggtaagcg aactggtatg ttagtaacgt     60

gtacaaagtt taggttcaga ccccgggagt cttgggcacg tgggtctcgg gtcactggtt    120

ttgactttag ggctttgtta cagatgtgtg accaagggga aaatgtgcat gacaacacta    180

gaggtatggg cgaagccaga aagaagggaa gttttggctg aagtaggagt cttgcgactg    240

catccgacat aaaggaacag ttgtgctctg cccacaaaca ggcgtccctt tccctctgga    300

taacaacaaa agcaagccgg gaggctggct gcctctcctc ctgctgtctc tgctggtggc    360

cacatgggtg ctggtggcag ggatctatct aatgtggagg cacgaaagga tcaagaagac    420

ttccttttct accaccacac tactgccccc cattaaggtt cttgtggttt acccatctga    480

aatatgtttc catcacacaa tttgttactt cactgaattt cttcaaaacc attgcagaag    540

tgaggtcatc cttgaaaagt ggcagaaaaa gaaaatagca gagatgggtc cagtgcagtg    600

gcttgccact caaaagaagg cagcagacaa agtcgtcttc cttctttcca atgacgtcaa    660

cagtgtgtgc gatggtacct gtggcaagag cgagggcagt cccagtgaga actctcaaga    720

cctcttcccc cttgccttta accttttctg cagtgatcta agaagccaga ttcatctgca    780

caaatacgtg gtggtctact ttagagagat tgatacaaaa gacgattaca atgctctcag    840

tgtctgcccc aagtaccacc tcatgaagga tgccactgct ttctgtgcag aacttctcca    900

tgtcaagcag caggtgtcag caggaaaaag atcacaagcc tgccacgatg gctgctgctc    960

cttgtagccc acccatgaga agcaagagac cttaaaggct tcctatccca ccaattacag   1020

ggaaaaaacg tgtgatgatc ctgaagctta ctatgcagcc tacaaacagc cttagtaatt   1080

aaaacatttt ataccaataa aattttcaaa tattgctaac taatgtagca ttaactaacg   1140

attggaaact acatttacaa cttcaaagct gttttataca tagaaatcaa ttacagtttt   1200

aattgaaaac tataaccatt ttgataatgc aacaataaag catcttcagc caaacatcta   1260

gtcttccata gaccatgcat tgcagtgtac ccagaactgt ttagctaata ttctatgttt   1320

aattaatgaa tactaactct aagaacccct cactgattca ctcaatagca tcttaagtga   1380

aaaaccttct attacatgca aaaaatcatt gtttttaaga taacaaaagt agggaataaa   1440

caagctgaac ccactttt                                                 1458


<210>  9366
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  9366

Met Trp Arg His Glu Arg Ile Lys Lys Thr Ser Phe Ser Thr Thr Thr 
1               5                   10                  15      


Leu Leu Pro Pro Ile Lys Val Leu Val Val Tyr Pro Ser Glu Ile Cys 
            20                  25                  30          


Phe His His Thr Ile Cys Tyr Phe Thr Glu Phe Leu Gln Asn His Cys 
        35                  40                  45              


Arg Ser Glu Val Ile Leu Glu Lys Trp Gln Lys Lys Lys Ile Ala Glu 
    50                  55                  60                  


Met Gly Pro Val Gln Trp Leu Ala Thr Gln Lys Lys Ala Ala Asp Lys 
65                  70                  75                  80  


Val Val Phe Leu Leu Ser Asn Asp Val Asn Ser Val Cys Asp Gly Thr 
                85                  90                  95      


Cys Gly Lys Ser Glu Gly Ser Pro Ser Glu Asn Ser Gln Asp Leu Phe 
            100                 105                 110         


Pro Leu Ala Phe Asn Leu Phe Cys Ser Asp Leu Arg Ser Gln Ile His 
        115                 120                 125             


Leu His Lys Tyr Val Val Val Tyr Phe Arg Glu Ile Asp Thr Lys Asp 
    130                 135                 140                 


Asp Tyr Asn Ala Leu Ser Val Cys Pro Lys Tyr His Leu Met Lys Asp 
145                 150                 155                 160 


Ala Thr Ala Phe Cys Ala Glu Leu Leu His Val Lys Gln Gln Val Ser 
                165                 170                 175     


Ala Gly Lys Arg Ser Gln Ala Cys His Asp Gly Cys Cys Ser Leu 
            180                 185                 190     


<210>  9367
<211>  1876
<212>  DNA
<213>  Homosapiens

<400>  9367
tctacgtggt aagatatgac ctagcccttt taggtaagcg aactggtatg ttagtaacgt     60

gtacaaagtt taggttcaga ccccgggagt cttgggcacg tgggtctcgg gtcactggtt    120

ttgactttag ggctttgtta cagatgtgtg accaagggga aaatgtgcat gacaacacta    180

gaggtatggg cgaagccaga aagaagggaa gttttggctg aagtaggagt cttgcgactg    240

catccgacat aaaggaacag ttgtgctctg cccacaaaca ggcgtccctt tccctctgga    300

taacaacaaa agcaagccgg gaggctggct gcctctcctc ctgctgtctc tgctggtggc    360

cacatgggtg ctggtggcag ggatctatct aatgtggagg cacgaaagga tcaagaagac    420

ttccttttct accaccacac tactgccccc cattaaggtt cttgtggttt acccatctga    480

aatatgtttc catcacacaa tttgttactt cactgaattt cttcaaaacc attgcagaag    540

tgaggtcatc cttgaaaagt ggcagaaaaa gaaaatagca gagatgggtc cagtgcagtg    600

gcttgccact caaaagaagg cagcagacaa agtcgtcttc cttctttcca atgacgtcaa    660

cagtgtgtgc gatggtacct gtggcaagag cgagggcagt cccagtgaga actctcaaga    720

cctcttcccc cttgccttta accttttctg cagtgatcta agaagccaga ttcatctgca    780

caaatacgtg gtggtctact ttagagagat tgatacaaaa gacgattaca atgctctcag    840

tgtctgcccc aagtaccacc tcatgaagga tgccactgct ttctgtgcag aacttctcca    900

tgtcaagcag caggtgtcag caggaaaaag atcacaagcc tgccacgatg gctgctgctc    960

cttgtagccc acccatgaga agcaagagac cttaaaggct tcctatccca ccaattacag   1020

ggaaaaaacg tgtgatgatc ctgaagctta ctatgcagcc tacaaacagc cttagtaatt   1080

aaaacatttt ataccaataa aattttcaaa tattgctaac taatgtagca ttaactaacg   1140

attggaaact acatttacaa cttcaaagct gttttataca tagaaatcaa ttacagtttt   1200

aattgaaaac tataaccatt ttgataatgc aacaataaag catcttcagc caaacatcta   1260

gtcttccata gaccatgcat tgcagtgtac ccagaactgt ttagctaata ttctatgttt   1320

aattaatgaa tactaactct aagaacccct cactgattca ctcaatagca tcttaagtga   1380

aaaaccttct attacatgca aaaaatcatt gtttttaaga taacaaaagt agggaataaa   1440

caagctgaac ccacttttac tggaccaaat gatctattat atgtgtaacc acttgtatga   1500

tttggtattt gcataagacc ttccctctac aaactagatt catatcttga ttcttgtaca   1560

ggtgcctttt aacatgaaca acaaaatacc cacaaacttg tctacttttg cctaaagtta   1620

cctattagag gtcactgtca gagttctcag tttcttagtt actatttaac ttttcatgtt   1680

caaaatgaaa ataattctta agttgaaagc cctcttgaag taaccttttt ataaatgagt   1740

tattataatg gtttacttaa ataaaaaaca ggggtgggtg cagtggctca tgcctccaat   1800

cccagcactt tggcaaggcc aaggcaaaag gatcgctcaa gaccaggcta cgtcacaaag   1860

cgagacctcc atctct                                                   1876


<210>  9368
<211>  191
<212>  PRT
<213>  Homosapiens

<400>  9368

Met Trp Arg His Glu Arg Ile Lys Lys Thr Ser Phe Ser Thr Thr Thr 
1               5                   10                  15      


Leu Leu Pro Pro Ile Lys Val Leu Val Val Tyr Pro Ser Glu Ile Cys 
            20                  25                  30          


Phe His His Thr Ile Cys Tyr Phe Thr Glu Phe Leu Gln Asn His Cys 
        35                  40                  45              


Arg Ser Glu Val Ile Leu Glu Lys Trp Gln Lys Lys Lys Ile Ala Glu 
    50                  55                  60                  


Met Gly Pro Val Gln Trp Leu Ala Thr Gln Lys Lys Ala Ala Asp Lys 
65                  70                  75                  80  


Val Val Phe Leu Leu Ser Asn Asp Val Asn Ser Val Cys Asp Gly Thr 
                85                  90                  95      


Cys Gly Lys Ser Glu Gly Ser Pro Ser Glu Asn Ser Gln Asp Leu Phe 
            100                 105                 110         


Pro Leu Ala Phe Asn Leu Phe Cys Ser Asp Leu Arg Ser Gln Ile His 
        115                 120                 125             


Leu His Lys Tyr Val Val Val Tyr Phe Arg Glu Ile Asp Thr Lys Asp 
    130                 135                 140                 


Asp Tyr Asn Ala Leu Ser Val Cys Pro Lys Tyr His Leu Met Lys Asp 
145                 150                 155                 160 


Ala Thr Ala Phe Cys Ala Glu Leu Leu His Val Lys Gln Gln Val Ser 
                165                 170                 175     


Ala Gly Lys Arg Ser Gln Ala Cys His Asp Gly Cys Cys Ser Leu 
            180                 185                 190     


<210>  9369
<211>  6111
<212>  DNA
<213>  Homosapiens

<400>  9369
gcgcgccggg acgccgaggg ctgggaggtg cggagcgcca ggagccaggc ggagcccccg     60

cagggacacc gctccgatct cccgcacgcc ccaccgtctg gttgtgtgcg ctcctgcccg    120

ggctctggcc tcagcttccc cgaccataaa acgaccacgg ttcaacaact ttaaggattg    180

gtcgagccac agacactctt cctgccagca ttcctcacgt cattgcccga agacacaaac    240

aacaagggca gcccctatac aaggacagtt ggctcctaag ggagggacta aataaaccag    300

aaagtaatga acaaagacaa aatggcctta aaatggtgga tcaagcaata tggtctaaaa    360

agatgtccaa tggtacaaga cgcattcctg tgtcccctga acaggcacgc tcctacaata    420

agcagatgcg acctgcaatt ttagatcact gttcgggaaa taagtggaca aacacatctc    480

atcaccctga gtatttagta ggagaagagg ccttgtatgt taatccactg gactgttaca    540

atattcactg gcctatcaga agaggtcagt taaatattca cccaggccct gggggctctc    600

ttacagctgt tctggcagat attgaagtaa tatggtctca tgcgatacaa aaatacttgg    660

aaatcccact gaaagattta aagtattata gatgtatctt gttaattcct gatatctata    720

ataagcagca tgtgaaagaa ctagtgaata tgatactaat gaagatgggt ttttcaggga    780

ttgtggtcca tcaggagtct gtgtgtgcca cctatggaag tggcttaagc agcacgtgta    840

ttgtagacgt tggggaccag aagacaagtg tatgctgtgt ggaggatggg gtgtctcatc    900

ggaatactcg gctttgtctg gcatacggag gatctgatgt gtcaagatgt ttttactggc    960

taatgcagcg agctgggttc ccttacagag aatgccagtt aacaaataaa atggattgtc   1020

ttcttctgca acaccttaaa gaaacttttt gtcatttaga tcaggacatc tctgggcttc   1080

aggaccatga gtttcagatt cgacatcctg attctcctgc cctgctttac cagtttcgat   1140

taggagatga aaaactgcag gctccaatgg ctttgtttta ccccgcaact tttggaatcg   1200

ttggacagaa aatgacgact ttgcagcaca gatctcaggg cgatcctgag gatcctcacg   1260

atgaacatta cctgctggcc acacagagca aacaagaaca gtctgcaaaa gctactgctg   1320

accgaaagtc tgcatccaaa cctattggat ttgaagggga tcttcgtggc cagtcctctg   1380

atcttccaga aagactccat tcccaggagg tagatttggg gtctgcacag ggagatggcc   1440

tgatggccgg caacgattcc gaggaggccc tcactgcact gatgtccagg aagactgcca   1500

tctcgctgtt tgaaggaaaa gccctgggcc tggataaagc catcctccat agcatagact   1560

gctgttcatc tgacgacacc aaaaagaaga tgtacagctc catcctagtg gtgggaggtg   1620

gtttgatgtt tcataaagct caagaatttc tgcagcacag aattctcaac aaaatgccac   1680

catccttcag gcgaattatt gaaaatgtgg atgtgatcac aaggcctaag gacatggacc   1740

cccggctgat tgcatggaaa ggaggggcag tgttggcttg tttggataca acacaggaac   1800

tgtggattta tcagcgagag tggcagcgct ttggtgtccg catgttacga gagcgggctg   1860

cgtttgtgtg gtgaatgggg aggaaatgtc actgccgaag accaaaaaca agcttcttgg   1920

tataaaagac tcttacagaa tatgtgtatt gtaatttatt gatctggatg cttaagtgtc   1980

atggacagta aatgaatttg aactttatgt tgaggacatg acattggttt gaaaatataa   2040

actgcttttg agcagtttag tcagggcatt tgagaataaa taggaacttt ctcttcagtt   2100

gtaaactctc ttgccctctc tcagggtctc ataaactccc cagtgatgta aacgttgcta   2160

ttgaaggttc tcatgtggtg aagcccttca tttaagttgg cttgaatctc atcagcaggc   2220

agcctcatgc aaccatgagg gatagtatgt gacgagggag aactgtccac tcatgccatt   2280

ttctctcttg tctagtattt cattaggatc taaagttgtc tgagttaaat gcacttatgt   2340

gactcatgtg tcctcttaga atcccaaata gggggaaaaa gttttggtgg tttttgtttt   2400

ttttttcatt ttctgttgga ttacagaaaa agaatgggac ccattcaggt ctcgatttcc   2460

aaaggtaaag atggaaggct gggcagactg gcttttgtta cctgacatgc cgtagggtga   2520

gcttagagga agaaagaaaa caatttttat ttggccaaaa cagaacaaat gctgaaaagg   2580

aaatcttgtt tttttcctaa agccaaatag aaatgatttg ggtataattt aagagtcctt   2640

gtgttgtaca gatatggtga ctgatgtagt tattaatact accaacttag tcatcaagcc   2700

tcaattttcc tttacctgaa ggattaagtg aaagcttttg gagttcatga tgttcagtat   2760

gatcagttaa ccttaacctc tgagcatcct gaagcaaaat ctaaataatg cagctattac   2820

cactggtggt ccaggctctg gtgaagccct ctgagcccag gaggaagaga aagcattgtc   2880

cagaggtagg aacacagtct gggagcccag agctctggga ggagtgggaa aatgctgctt   2940

cctgctgctt gcttctaggc acctgcttcc gccatctcac ttaccatggc tagagatggg   3000

ggtgagactg gggaaggaca aaagcaggga acagataagt gatggaaatc agaagggaat   3060

atagaaagaa ctctggatgt ggagaaatgc cggtacctga gcattttgta tcaatgggag   3120

taccctctgt aactgctcag taggttacaa atgaagagtc caccagtatt agaaacaatt   3180

taaacttgcc agtaccaact gggatgtgtg ccttcaattt gaaaattgta tgttttattt   3240

tttaaatttg ttaacagcat taatttatag agtattgatg tcatttatgt ttctgaggtg   3300

tttcaacaca attttggatc agctgcctgt ttgcaaaaac ataatatatt tctgttaaac   3360

agttcttcac ctaacagcat attgctctta taactggtag agctgtttca aaggaagttg   3420

gtttctggtc caagttttga cctaaaccat gtccatcttc tattaccagc acttacaagc   3480

actgtgaaaa ctgatcatga caaataagta aaatttgcta cattaaacat attgcctcag   3540

ccattactaa gcgtccactt gtaaagctgg acacagtttt tactttatgc ttcattttga   3600

ttttttatcc gtaagacata aattagaagg catgaggtgg ccctttaagg ataatctgca   3660

aatatacaca ttttaatagt catccatctg aaatcgatcc acattccaga gaagattcag   3720

tattgtgctg tgtgaaataa gcattcccag aaaaaaaaca tttatgctaa taatacaaca   3780

taacctctgc attaaagaaa aagatgcttt taggccaggc gccgtggctc acacctgtaa   3840

tccctgcact ttgagaggct gaggtgggtg gatcatgagg tcaggagatc aagaccatcc   3900

tggctaacag ggtgaaaccc cgtctctact aaaaatataa aaagttagct gggtgtggtg   3960

gtgggtgcct gtagtcccag ctactcagga ggctgaggca ggagaatggc gtgaacccgg   4020

aaggcagagg ttgtagtgag ccgaggtcac gccactgcac tccagcctgg gtgacagagt   4080

gaaactctgt ctcaaaaaaa aaaaatttaa aaaatttaaa aaagatgctt ttagaagagt   4140

aaaaagttgg aagacaaaat gtgcatcttt tatgttctgt cattctgtgg gggttttttc   4200

gtttgtttgt tttagacagg gtctgctctc acccaggatg gagtgcagtg gcacaatcac   4260

cgtttactgc acccttgacc tccagggctc aagtgatcct cccatctcag cctccctagt   4320

agctgggacc acaggcttac accatcacac tcagctaatt ttttaaatct tttgtagaga   4380

tggaggtctc gctttgtgac gtagcctggt cttgagcgat ccttttgcct tggccttgcc   4440

aaagtgctgg gattggaggc atgagccact gcacccaccc ctgtttttta tttaagtaaa   4500

ccattataat aactcattta taaaaaggtt acttcaagag ggctttcaac ttaagaatta   4560

ttttcatttt gaacatgaaa agttaaatag taactaagaa actgagaact ctgacagtga   4620

cctctaatag gtaactttag gcaaaagtag acaagtttgt gggtattttg ttgttcatgt   4680

taaaaggcac ctgtacaaga atcaagatat gaatctagtt tgtagaggga aggtcttatg   4740

caaataccaa atcatacaag tggttacaca tataatagat catttggtcc agtaaaagtg   4800

ggttcagctt gtttattccc tacttttgtt atcttaaaaa caatgatttt ttgcatgtaa   4860

tagaaggttt ttcacttaag atgctattga gtgaatcagt gaggggttct tagagttagt   4920

attcattaat taaacataga atattagcta aacagttctg ggtacactgc aatgcatggt   4980

ctatggaaga ctagatgttt ggctgaagat gctttattgt tgcattatca aaatggttat   5040

agttttcaat taaaactgta attgatttct atgtataaaa cagctttgaa gttgtaaatg   5100

tagtttccaa tcgttagtta atgctacatt agttagcaat atttgaaaat tttattggta   5160

taaaatgttt taattactaa ggctgtttgt aggctgcata gtaagcttca ggatcatcac   5220

acgttttttc cctgtaattg gtgggatagg aagcctttaa ggtctcttgc ttctcatggg   5280

tgggctacaa ggagcagcag ccatcgtggc aggcttgtga tctttttcct gctgacacct   5340

gctgcttgac atggagaagt tctgcacaga aagcagtggc atccttcatg aggtggtact   5400

tggggcagac actgagagca ttgtaatcgt cttttgtatc aatctctcta aagtagacca   5460

ccacgtattt gtgcagatga atctggcttc ttagatcact gcagaaaagg ttaaaggcaa   5520

gggggaagag gtcttgagag ttctcactgg gactgccctc gctcttgcca caggtaccat   5580

cgcacacact gttgacgtca ttggaaagaa ggaagacgac tttgtctgct gccttctttt   5640

gagtggcaag ccactgcact ggacccatct ctgctatttt ctttttctgc cacttttcaa   5700

ggatgacctc acttctgcaa tggttttgaa gaaattcagt gaagtaacaa attgtgtgat   5760

ggaaacatat ttcagatggg taaaccacaa gaaccttaat ggggggcagt agtgtggtgg   5820

tagaaaagga agtcttcttg atcctttctg tgagaggaga aaagcatttg ttatctgtga   5880

acagcaaaca gcaggctttc actctgtaaa ccatccctga caaatgatcc cttgctagag   5940

aatgtcagct gagcaccaag ggccttgtta gtgacagcaa ggaaaaacat cctgatgttc   6000

cttttgaaca catcacctga aacacactga tgcttaaacc ttaacttttt tttttttgga   6060

gacatagtct cactctgtcg cccaggctgg agtgcagtgg cgtgacctcg g            6111


<210>  9370
<211>  513
<212>  PRT
<213>  Homosapiens

<400>  9370

Met Val Asp Gln Ala Ile Trp Ser Lys Lys Met Ser Asn Gly Thr Arg 
1               5                   10                  15      


Arg Ile Pro Val Ser Pro Glu Gln Ala Arg Ser Tyr Asn Lys Gln Met 
            20                  25                  30          


Arg Pro Ala Ile Leu Asp His Cys Ser Gly Asn Lys Trp Thr Asn Thr 
        35                  40                  45              


Ser His His Pro Glu Tyr Leu Val Gly Glu Glu Ala Leu Tyr Val Asn 
    50                  55                  60                  


Pro Leu Asp Cys Tyr Asn Ile His Trp Pro Ile Arg Arg Gly Gln Leu 
65                  70                  75                  80  


Asn Ile His Pro Gly Pro Gly Gly Ser Leu Thr Ala Val Leu Ala Asp 
                85                  90                  95      


Ile Glu Val Ile Trp Ser His Ala Ile Gln Lys Tyr Leu Glu Ile Pro 
            100                 105                 110         


Leu Lys Asp Leu Lys Tyr Tyr Arg Cys Ile Leu Leu Ile Pro Asp Ile 
        115                 120                 125             


Tyr Asn Lys Gln His Val Lys Glu Leu Val Asn Met Ile Leu Met Lys 
    130                 135                 140                 


Met Gly Phe Ser Gly Ile Val Val His Gln Glu Ser Val Cys Ala Thr 
145                 150                 155                 160 


Tyr Gly Ser Gly Leu Ser Ser Thr Cys Ile Val Asp Val Gly Asp Gln 
                165                 170                 175     


Lys Thr Ser Val Cys Cys Val Glu Asp Gly Val Ser His Arg Asn Thr 
            180                 185                 190         


Arg Leu Cys Leu Ala Tyr Gly Gly Ser Asp Val Ser Arg Cys Phe Tyr 
        195                 200                 205             


Trp Leu Met Gln Arg Ala Gly Phe Pro Tyr Arg Glu Cys Gln Leu Thr 
    210                 215                 220                 


Asn Lys Met Asp Cys Leu Leu Leu Gln His Leu Lys Glu Thr Phe Cys 
225                 230                 235                 240 


His Leu Asp Gln Asp Ile Ser Gly Leu Gln Asp His Glu Phe Gln Ile 
                245                 250                 255     


Arg His Pro Asp Ser Pro Ala Leu Leu Tyr Gln Phe Arg Leu Gly Asp 
            260                 265                 270         


Glu Lys Leu Gln Ala Pro Met Ala Leu Phe Tyr Pro Ala Thr Phe Gly 
        275                 280                 285             


Ile Val Gly Gln Lys Met Thr Thr Leu Gln His Arg Ser Gln Gly Asp 
    290                 295                 300                 


Pro Glu Asp Pro His Asp Glu His Tyr Leu Leu Ala Thr Gln Ser Lys 
305                 310                 315                 320 


Gln Glu Gln Ser Ala Lys Ala Thr Ala Asp Arg Lys Ser Ala Ser Lys 
                325                 330                 335     


Pro Ile Gly Phe Glu Gly Asp Leu Arg Gly Gln Ser Ser Asp Leu Pro 
            340                 345                 350         


Glu Arg Leu His Ser Gln Glu Val Asp Leu Gly Ser Ala Gln Gly Asp 
        355                 360                 365             


Gly Leu Met Ala Gly Asn Asp Ser Glu Glu Ala Leu Thr Ala Leu Met 
    370                 375                 380                 


Ser Arg Lys Thr Ala Ile Ser Leu Phe Glu Gly Lys Ala Leu Gly Leu 
385                 390                 395                 400 


Asp Lys Ala Ile Leu His Ser Ile Asp Cys Cys Ser Ser Asp Asp Thr 
                405                 410                 415     


Lys Lys Lys Met Tyr Ser Ser Ile Leu Val Val Gly Gly Gly Leu Met 
            420                 425                 430         


Phe His Lys Ala Gln Glu Phe Leu Gln His Arg Ile Leu Asn Lys Met 
        435                 440                 445             


Pro Pro Ser Phe Arg Arg Ile Ile Glu Asn Val Asp Val Ile Thr Arg 
    450                 455                 460                 


Pro Lys Asp Met Asp Pro Arg Leu Ile Ala Trp Lys Gly Gly Ala Val 
465                 470                 475                 480 


Leu Ala Cys Leu Asp Thr Thr Gln Glu Leu Trp Ile Tyr Gln Arg Glu 
                485                 490                 495     


Trp Gln Arg Phe Gly Val Arg Met Leu Arg Glu Arg Ala Ala Phe Val 
            500                 505                 510         


Trp 
    


<210>  9371
<211>  6187
<212>  DNA
<213>  Homosapiens

<400>  9371
gcgcggtggc ccttccatcc cggcagtcgt ggctgcagcg ctgaggcgag aggttggtgg     60

gtgtctccgg ccataatgac ccaggctgag aagggtgata cggagaacgg aaaggagaag    120

ggcggcgaga aggagaagga gcagcgcggc gtgaagcggc ccatcgtgcc cgcgctggtg    180

ccggagtcgc tgcaagagca aatccagagc aacttcatca ttgtcataca tccaggttca    240

acaactttaa ggattggtcg agccacagac actcttcctg ccagcattcc tcacgtcatt    300

gcccgaagac acaaacaaca agggcagccc ctatacaagg acagttggct cctaagggag    360

ggactaaata aaccagaaag taatgaacaa agacaaaatg gccttaaaat ggtggatcaa    420

gcaatatggt ctaaaaagat gtccaatggt acaagacgca ttcctgtgtc ccctgaacag    480

gcacgctcct acaataagca gatgcgacct gcaattttag atcactgttc gggaaataag    540

tggacaaaca catctcatca ccctgagtat ttagtaggag aagaggcctt gtatgttaat    600

ccactggact gttacaatat tcactggcct atcagaagag gtcagttaaa tattcaccca    660

ggccctgggg gctctcttac agctgttctg gcagatattg aagtaatatg gtctcatgcg    720

atacaaaaat acttggaaat cccactgaaa gatttaaagt attatagatg tatcttgtta    780

attcctgata tctataataa gcagcatgtg aaagaactag tgaatatgat actaatgaag    840

atgggttttt cagggattgt ggtccatcag gagtctgtgt gtgccaccta tggaagtggc    900

ttaagcagca cgtgtattgt agacgttggg gaccagaaga caagtgtatg ctgtgtggag    960

gatggggtgt ctcatcggaa tactcggctt tgtctggcat acggaggatc tgatgtgtca   1020

agatgttttt actggctaat gcagcgagct gggttccctt acagagaatg ccagttaaca   1080

aataaaatgg attgtcttct tctgcaacac cttaaagaaa ctttttgtca tttagatcag   1140

gacatctctg ggcttcagga ccatgagttt cagattcgac atcctgattc tcctgccctg   1200

ctttaccagt ttcgattagg agatgaaaaa ctgcaggctc caatggcttt gttttacccc   1260

gcaacttttg gaatcgttgg acagaaaatg acgactttgc agcacagatc tcagggcgat   1320

cctgaggatc ctcacgatga acattacctg ctggccacac agagcaaaca agaacagtct   1380

gcaaaagcta ctgctgaccg aaagtctgca tccaaaccta ttggatttga aggggatctt   1440

cgtggccagt cctctgatct tccagaaaga ctccattccc aggaggtaga tttggggtct   1500

gcacagggag atggcctgat ggccggcaac gattccgagg aggccctcac tgcactgatg   1560

tccaggaaga ctgccatctc gctgtttgaa ggaaaagccc tgggcctgga taaagccatc   1620

ctccatagca tagactgctg ttcatctgac gacaccaaaa agaagatgta cagctccatc   1680

ctagtggtgg gaggtggttt gatgtttcat aaagctcaag aatttctgca gcacagaatt   1740

ctcaacaaaa tgccaccatc cttcaggcga attattgaaa atgtggatgt gatcacaagg   1800

cctaaggaca tggacccccg gctgattgca tggaaaggag gggcagtgtt ggcttgtttg   1860

gatacaacac aggaactgtg gatttatcag cgagagtggc agcgctttgg tgtccgcatg   1920

ttacgagagc gggctgcgtt tgtgtggtga atggggagga aatgtcactg ccgaagacca   1980

aaaacaagct tcttggtata aaagactctt acagaatatg tgtattgtaa tttattgatc   2040

tggatgctta agtgtcatgg acagtaaatg aatttgaact ttatgttgag gacatgacat   2100

tggtttgaaa atataaactg cttttgagca gtttagtcag ggcatttgag aataaatagg   2160

aactttctct tcagttgtaa actctcttgc cctctctcag ggtctcataa actccccagt   2220

gatgtaaacg ttgctattga aggttctcat gtggtgaagc ccttcattta agttggcttg   2280

aatctcatca gcaggcagcc tcatgcaacc atgagggata gtatgtgacg agggagaact   2340

gtccactcat gccattttct ctcttgtcta gtatttcatt aggatctaaa gttgtctgag   2400

ttaaatgcac ttatgtgact catgtgtcct cttagaatcc caaatagggg gaaaaagttt   2460

tggtggtttt tgtttttttt ttcattttct gttggattac agaaaaagaa tgggacccat   2520

tcaggtctcg atttccaaag gtaaagatgg aaggctgggc agactggctt ttgttacctg   2580

acatgccgta gggtgagctt agaggaagaa agaaaacaat ttttatttgg ccaaaacaga   2640

acaaatgctg aaaaggaaat cttgtttttt tcctaaagcc aaatagaaat gatttgggta   2700

taatttaaga gtccttgtgt tgtacagata tggtgactga tgtagttatt aatactacca   2760

acttagtcat caagcctcaa ttttccttta cctgaaggat taagtgaaag cttttggagt   2820

tcatgatgtt cagtatgatc agttaacctt aacctctgag catcctgaag caaaatctaa   2880

ataatgcagc tattaccact ggtggtccag gctctggtga agccctctga gcccaggagg   2940

aagagaaagc attgtccaga ggtaggaaca cagtctggga gcccagagct ctgggaggag   3000

tgggaaaatg ctgcttcctg ctgcttgctt ctaggcacct gcttccgcca tctcacttac   3060

catggctaga gatgggggtg agactgggga aggacaaaag cagggaacag ataagtgatg   3120

gaaatcagaa gggaatatag aaagaactct ggatgtggag aaatgccggt acctgagcat   3180

tttgtatcaa tgggagtacc ctctgtaact gctcagtagg ttacaaatga agagtccacc   3240

agtattagaa acaatttaaa cttgccagta ccaactggga tgtgtgcctt caatttgaaa   3300

attgtatgtt ttatttttta aatttgttaa cagcattaat ttatagagta ttgatgtcat   3360

ttatgtttct gaggtgtttc aacacaattt tggatcagct gcctgtttgc aaaaacataa   3420

tatatttctg ttaaacagtt cttcacctaa cagcatattg ctcttataac tggtagagct   3480

gtttcaaagg aagttggttt ctggtccaag ttttgaccta aaccatgtcc atcttctatt   3540

accagcactt acaagcactg tgaaaactga tcatgacaaa taagtaaaat ttgctacatt   3600

aaacatattg cctcagccat tactaagcgt ccacttgtaa agctggacac agtttttact   3660

ttatgcttca ttttgatttt ttatccgtaa gacataaatt agaaggcatg aggtggccct   3720

ttaaggataa tctgcaaata tacacatttt aatagtcatc catctgaaat cgatccacat   3780

tccagagaag attcagtatt gtgctgtgtg aaataagcat tcccagaaaa aaaacattta   3840

tgctaataat acaacataac ctctgcatta aagaaaaaga tgcttttagg ccaggcgccg   3900

tggctcacac ctgtaatccc tgcactttga gaggctgagg tgggtggatc atgaggtcag   3960

gagatcaaga ccatcctggc taacagggtg aaaccccgtc tctactaaaa atataaaaag   4020

ttagctgggt gtggtggtgg gtgcctgtag tcccagctac tcaggaggct gaggcaggag   4080

aatggcgtga acccggaagg cagaggttgt agtgagccga ggtcacgcca ctgcactcca   4140

gcctgggtga cagagtgaaa ctctgtctca aaaaaaaaaa atttaaaaaa tttaaaaaag   4200

atgcttttag aagagtaaaa agttggaaga caaaatgtgc atcttttatg ttctgtcatt   4260

ctgtgggggt tttttcgttt gtttgtttta gacagggtct gctctcaccc aggatggagt   4320

gcagtggcac aatcaccgtt tactgcaccc ttgacctcca gggctcaagt gatcctccca   4380

tctcagcctc cctagtagct gggaccacag gcttacacca tcacactcag ctaatttttt   4440

aaatcttttg tagagatgga ggtctcgctt tgtgacgtag cctggtcttg agcgatcctt   4500

ttgccttggc cttgccaaag tgctgggatt ggaggcatga gccactgcac ccacccctgt   4560

tttttattta agtaaaccat tataataact catttataaa aaggttactt caagagggct   4620

ttcaacttaa gaattatttt cattttgaac atgaaaagtt aaatagtaac taagaaactg   4680

agaactctga cagtgacctc taataggtaa ctttaggcaa aagtagacaa gtttgtgggt   4740

attttgttgt tcatgttaaa aggcacctgt acaagaatca agatatgaat ctagtttgta   4800

gagggaaggt cttatgcaaa taccaaatca tacaagtggt tacacatata atagatcatt   4860

tggtccagta aaagtgggtt cagcttgttt attccctact tttgttatct taaaaacaat   4920

gattttttgc atgtaataga aggtttttca cttaagatgc tattgagtga atcagtgagg   4980

ggttcttaga gttagtattc attaattaaa catagaatat tagctaaaca gttctgggta   5040

cactgcaatg catggtctat ggaagactag atgtttggct gaagatgctt tattgttgca   5100

ttatcaaaat ggttatagtt ttcaattaaa actgtaattg atttctatgt ataaaacagc   5160

tttgaagttg taaatgtagt ttccaatcgt tagttaatgc tacattagtt agcaatattt   5220

gaaaatttta ttggtataaa atgttttaat tactaaggct gtttgtaggc tgcatagtaa   5280

gcttcaggat catcacacgt tttttccctg taattggtgg gataggaagc ctttaaggtc   5340

tcttgcttct catgggtggg ctacaaggag cagcagccat cgtggcaggc ttgtgatctt   5400

tttcctgctg acacctgctg cttgacatgg agaagttctg cacagaaagc agtggcatcc   5460

ttcatgaggt ggtacttggg gcagacactg agagcattgt aatcgtcttt tgtatcaatc   5520

tctctaaagt agaccaccac gtatttgtgc agatgaatct ggcttcttag atcactgcag   5580

aaaaggttaa aggcaagggg gaagaggtct tgagagttct cactgggact gccctcgctc   5640

ttgccacagg taccatcgca cacactgttg acgtcattgg aaagaaggaa gacgactttg   5700

tctgctgcct tcttttgagt ggcaagccac tgcactggac ccatctctgc tattttcttt   5760

ttctgccact tttcaaggat gacctcactt ctgcaatggt tttgaagaaa ttcagtgaag   5820

taacaaattg tgtgatggaa acatatttca gatgggtaaa ccacaagaac cttaatgggg   5880

ggcagtagtg tggtggtaga aaaggaagtc ttcttgatcc tttctgtgag aggagaaaag   5940

catttgttat ctgtgaacag caaacagcag gctttcactc tgtaaaccat ccctgacaaa   6000

tgatcccttg ctagagaatg tcagctgagc accaagggcc ttgttagtga cagcaaggaa   6060

aaacatcctg atgttccttt tgaacacatc acctgaaaca cactgatgct taaaccttaa   6120

cttttttttt tttggagaca tagtctcact ctgtcgccca ggctggagtg cagtggcgtg   6180

acctcgg                                                             6187


<210>  9372
<211>  624
<212>  PRT
<213>  Homosapiens

<400>  9372

Met Thr Gln Ala Glu Lys Gly Asp Thr Glu Asn Gly Lys Glu Lys Gly 
1               5                   10                  15      


Gly Glu Lys Glu Lys Glu Gln Arg Gly Val Lys Arg Pro Ile Val Pro 
            20                  25                  30          


Ala Leu Val Pro Glu Ser Leu Gln Glu Gln Ile Gln Ser Asn Phe Ile 
        35                  40                  45              


Ile Val Ile His Pro Gly Ser Thr Thr Leu Arg Ile Gly Arg Ala Thr 
    50                  55                  60                  


Asp Thr Leu Pro Ala Ser Ile Pro His Val Ile Ala Arg Arg His Lys 
65                  70                  75                  80  


Gln Gln Gly Gln Pro Leu Tyr Lys Asp Ser Trp Leu Leu Arg Glu Gly 
                85                  90                  95      


Leu Asn Lys Pro Glu Ser Asn Glu Gln Arg Gln Asn Gly Leu Lys Met 
            100                 105                 110         


Val Asp Gln Ala Ile Trp Ser Lys Lys Met Ser Asn Gly Thr Arg Arg 
        115                 120                 125             


Ile Pro Val Ser Pro Glu Gln Ala Arg Ser Tyr Asn Lys Gln Met Arg 
    130                 135                 140                 


Pro Ala Ile Leu Asp His Cys Ser Gly Asn Lys Trp Thr Asn Thr Ser 
145                 150                 155                 160 


His His Pro Glu Tyr Leu Val Gly Glu Glu Ala Leu Tyr Val Asn Pro 
                165                 170                 175     


Leu Asp Cys Tyr Asn Ile His Trp Pro Ile Arg Arg Gly Gln Leu Asn 
            180                 185                 190         


Ile His Pro Gly Pro Gly Gly Ser Leu Thr Ala Val Leu Ala Asp Ile 
        195                 200                 205             


Glu Val Ile Trp Ser His Ala Ile Gln Lys Tyr Leu Glu Ile Pro Leu 
    210                 215                 220                 


Lys Asp Leu Lys Tyr Tyr Arg Cys Ile Leu Leu Ile Pro Asp Ile Tyr 
225                 230                 235                 240 


Asn Lys Gln His Val Lys Glu Leu Val Asn Met Ile Leu Met Lys Met 
                245                 250                 255     


Gly Phe Ser Gly Ile Val Val His Gln Glu Ser Val Cys Ala Thr Tyr 
            260                 265                 270         


Gly Ser Gly Leu Ser Ser Thr Cys Ile Val Asp Val Gly Asp Gln Lys 
        275                 280                 285             


Thr Ser Val Cys Cys Val Glu Asp Gly Val Ser His Arg Asn Thr Arg 
    290                 295                 300                 


Leu Cys Leu Ala Tyr Gly Gly Ser Asp Val Ser Arg Cys Phe Tyr Trp 
305                 310                 315                 320 


Leu Met Gln Arg Ala Gly Phe Pro Tyr Arg Glu Cys Gln Leu Thr Asn 
                325                 330                 335     


Lys Met Asp Cys Leu Leu Leu Gln His Leu Lys Glu Thr Phe Cys His 
            340                 345                 350         


Leu Asp Gln Asp Ile Ser Gly Leu Gln Asp His Glu Phe Gln Ile Arg 
        355                 360                 365             


His Pro Asp Ser Pro Ala Leu Leu Tyr Gln Phe Arg Leu Gly Asp Glu 
    370                 375                 380                 


Lys Leu Gln Ala Pro Met Ala Leu Phe Tyr Pro Ala Thr Phe Gly Ile 
385                 390                 395                 400 


Val Gly Gln Lys Met Thr Thr Leu Gln His Arg Ser Gln Gly Asp Pro 
                405                 410                 415     


Glu Asp Pro His Asp Glu His Tyr Leu Leu Ala Thr Gln Ser Lys Gln 
            420                 425                 430         


Glu Gln Ser Ala Lys Ala Thr Ala Asp Arg Lys Ser Ala Ser Lys Pro 
        435                 440                 445             


Ile Gly Phe Glu Gly Asp Leu Arg Gly Gln Ser Ser Asp Leu Pro Glu 
    450                 455                 460                 


Arg Leu His Ser Gln Glu Val Asp Leu Gly Ser Ala Gln Gly Asp Gly 
465                 470                 475                 480 


Leu Met Ala Gly Asn Asp Ser Glu Glu Ala Leu Thr Ala Leu Met Ser 
                485                 490                 495     


Arg Lys Thr Ala Ile Ser Leu Phe Glu Gly Lys Ala Leu Gly Leu Asp 
            500                 505                 510         


Lys Ala Ile Leu His Ser Ile Asp Cys Cys Ser Ser Asp Asp Thr Lys 
        515                 520                 525             


Lys Lys Met Tyr Ser Ser Ile Leu Val Val Gly Gly Gly Leu Met Phe 
    530                 535                 540                 


His Lys Ala Gln Glu Phe Leu Gln His Arg Ile Leu Asn Lys Met Pro 
545                 550                 555                 560 


Pro Ser Phe Arg Arg Ile Ile Glu Asn Val Asp Val Ile Thr Arg Pro 
                565                 570                 575     


Lys Asp Met Asp Pro Arg Leu Ile Ala Trp Lys Gly Gly Ala Val Leu 
            580                 585                 590         


Ala Cys Leu Asp Thr Thr Gln Glu Leu Trp Ile Tyr Gln Arg Glu Trp 
        595                 600                 605             


Gln Arg Phe Gly Val Arg Met Leu Arg Glu Arg Ala Ala Phe Val Trp 
    610                 615                 620                 


<210>  9373
<211>  5095
<212>  DNA
<213>  Homosapiens

<400>  9373
gcgcgccggg acgccgaggg ctgggaggtg cggagcgcca ggagccaggc ggagcccccg     60

cagggacacc gctccgatct cccgcacgcc ccaccgtctg gttgtgtgcg ctcctgcccg    120

ggctctggcc tcagcttccc cgaccataaa acgaccacgg ttcaacaact ttaaggattg    180

gtcgagccac agacactctt cctgccagca ttcctcacgt cattgcccga agacacaaac    240

aacaagggca gcccctatac aaggacagtt ggctcctaag ggagggacta aataaaccag    300

aaagtaatga acaaagacaa aatggcctta aaatggtgga tcaagcaata tggtctaaaa    360

agatgtccaa tggtacaaga cgcattcctg tgtcccctga acaggcacgc tcctacaata    420

agcagatgcg acctgcaatt ttagatcact gttcgggaaa taagtggaca aacacatctc    480

atcaccctga gtatttagta ggagaagagg ccttgtatgt taatccactg gactgttaca    540

atattcactg gcctatcaga agaggtcagt taaatattca cccaggccct gggggctctc    600

ttacagctgt tctggcagat attgaagtaa tatggtctca tgcgatacaa aaatacttgg    660

aaatcccact gaaagattta aagtattata gatgtatctt gttaattcct gatatctata    720

ataagcagca tgtgaaagaa ctagtgaata tgatactaat gaagatgggt ttttcaggga    780

ttgtggtcca tcaggagtct gtgtgtgcca cctatggaag tggcttaagc agcacgtgta    840

ttgtagacgt tggggaccag aagacaagtg tatgctgtgt ggaggatggg gtgtctcatc    900

ggaatactcg gctttgtctg gcatacggag gatctgatgt gtcaagatgt ttttactggc    960

taatgcagcg agctgggttc ccttacagag aatgccagtt aacaaataaa atggattgtc   1020

ttcttctgca acaccttaaa gaaacttttt gtcatttaga tcaggacatc tctgggcttc   1080

aggaccatga gtttcagatt cgacatcctg attctcctgc cctgctttac cagtttcgat   1140

taggagatga aaaactgcag gctccaatgg ctttgtttta ccccgcaact tttggaatcg   1200

ttggacagaa aatgacgact ttgcagcaca gatctcaggg cgatcctgag gatcctcacg   1260

atgaacatta cctgctggcc acacagagca aacaagaaca gtctgcaaaa gctactgctg   1320

accgaaagtc tgcatccaaa cctattggat ttgaagggga tcttcgtggc cagtcctctg   1380

atcttccaga aagactccat tcccaggagg tagatttggg gtctgcacag ggagatggcc   1440

tgatggccgg caacgattcc gaggaggccc tcactgcact gatgtccagg aagactgcca   1500

tctcgctgtt tgaaggaaaa gccctgggcc tggataaagc catcctccat agcatagact   1560

gctgttcatc tgacgacacc aaaaagaaga tgtacagctc catcctagtg gtgggaggtg   1620

gtttgatgtt tcataaagct caagaatttc tgcagcacag aattctcaac aaaatgccac   1680

catccttcag gcgaattatt gaaaatgtgg atgtgatcac aaggcctaag gacatggacc   1740

cccggctgat tgcatggaaa ggaggggcag tgttggcttg tttggataca acacaggaac   1800

tgtggattta tcagcgagag tggcagcgct ttggtgtccg catgttacga gagcgggctg   1860

cgtttgtgtg gtgaatgggg aggaaatgtc actgccgaag accaaaaaca agcttcttgg   1920

tataaaagac tcttacagaa tatgtgtatt gtaatttatt gatctggatg cttaagtgtc   1980

atggacagta aatgaatttg aactttatgt tgaggacatg acattggttt gaaaatataa   2040

actgcttttg agcagtttag tcagggcatt tgagaataaa taggaacttt ctcttcagtt   2100

gtaaactctc ttgccctctc tcagggtctc ataaactccc cagtgatgta aacgttgcta   2160

ttgaaggttc tcatgtggtg aagcccttca tttaagttgg cttgaatctc atcagcaggc   2220

agcctcatgc aaccatgagg gatagtatgt gacgagggag aactgtccac tcatgccatt   2280

ttctctcttg tctagtattt cattaggatc taaagttgtc tgagttaaat gcacttatgt   2340

gactcatgtg tcctcttaga atcccaaata gggggaaaaa gttttggtgg tttttgtttt   2400

ttttttcatt ttctgttgga ttacagaaaa agaatgggac ccattcaggt ctcgatttcc   2460

aaaggtaaag atggaaggct gggcagactg gcttttgtta cctgacatgc cgtagggtga   2520

gcttagagga agaaagaaaa caatttttat ttggccaaaa cagaacaaat gctgaaaagg   2580

aaatcttgtt tttttcctaa agccaaatag aaatgatttg ggtataattt aagagtcctt   2640

gtgttgtaca gatatggtga ctgatgtagt tattaatact accaacttag tcatcaagcc   2700

tcaattttcc tttacctgaa ggattaagtg aaagcttttg gagttcatga tgttcagtat   2760

gatcagttaa ccttaacctc tgagcatcct gaagcaaaat ctaaataatg cagctattac   2820

cactggtggt ccaggctctg gtgaagccct ctgagcccag gaggaagaga aagcattgtc   2880

cagaggtagg aacacagtct gggagcccag agctctggga ggagtgggaa aatgctgctt   2940

cctgctgctt gcttctaggc acctgcttcc gccatctcac ttaccatggc tagagatggg   3000

ggtgagactg gggaaggaca aaagcaggga acagataagt gatggaaatc agaagggaat   3060

atagaaagaa ctctggatgt ggagaaatgc cggtacctga gcattttgta tcaatgggag   3120

taccctctgt aactgctcag taggttacaa atgaagagtc caccagtatt agaaacaatt   3180

taaacttgcc agtaccaact gggatgtgtg ccttcaattt gaaaattgta tgttttattt   3240

tttaaatttg ttaacagcat taatttatag agtattgatg tcatttatgt ttctgaggtg   3300

tttcaacaca attttggatc agctgcctgt ttgcaaaaac ataatatatt tctgttaaac   3360

agttcttcac ctaacagcat attgctctta taactggtag agctgtttca aaggaagttg   3420

gtttctggtc caagttttga cctaaaccat gtccatcttc tattaccagc acttacaagc   3480

actgtgaaaa ctgatcatga caaataagta aaatttgcta cattaaacat attgcctcag   3540

ccattactaa gcgtccactt gtaaagctgg acacagtttt tactttatgc ttcattttga   3600

ttttttatcc gtaagacata aattagaagg catgaggtgg ccctttaagg ataatctgca   3660

aatatacaca ttttaatagt catccatctg aaatcgatcc acattccaga gaagattcag   3720

tattgtgctg tgtgaaataa gcattcccag aaaaaaaaca tttatgctaa taatacaaca   3780

taacctctgc attaaagaaa aagatgcttt taggccaggc gccgtggctc acacctgtaa   3840

tccctgcact ttgagaggct gaggtgggtg gatcatgagg tcaggagatc aagaccatcc   3900

tggctaacag ggtgaaaccc cgtctctact aaaaatataa aaagttagct gggtgtggtg   3960

gtgggtgcct gtagtcccag ctactcagga ggctgaggca ggagaatggc gtgaacccgg   4020

aaggcagagg ttgtagtgag ccgaggtcac gccactgcac tccagcctgg gtgacagagt   4080

gaaactctgt ctcaaaaaaa aaaaatttaa aaaatttaaa aaagatgctt ttagaagagt   4140

aaaaagttgg aagacaaaat gtgcatcttt tatgttctgt cattctgtgg gggttttttc   4200

gtttgtttgt tttagacagg gtctgctctc acccaggatg gagtgcagtg gcacaatcac   4260

cgtttactgc acccttgacc tccagggctc aagtgatcct cccatctcag cctccctagt   4320

agctgggacc acaggcttac accatcacac tcagctaatt ttttaaatct tttgtagaga   4380

tggaggtctc gctttgtgac gtagcctggt cttgagcgat ccttttgcct tggccttgcc   4440

aaagtgctgg gattggaggc atgagccact gcacccaccc ctgtttttta tttaagtaaa   4500

ccattataat aactcattta taaaaaggtt acttcaagag ggctttcaac ttaagaatta   4560

ttttcatttt gaacatgaaa agttaaatag taactaagaa actgagaact ctgacagtga   4620

cctctaatag gtaactttag gcaaaagtag acaagtttgt gggtattttg ttgttcatgt   4680

taaaaggcac ctgtacaaga atcaagatat gaatctagtt tgtagaggga aggtcttatg   4740

caaataccaa atcatacaag tggttacaca tataatagat catttggtcc agtaaaagtg   4800

ggttcagctt gtttattccc tacttttgtt atcttaaaaa caatgatttt ttgcatgtaa   4860

tagaaggttt ttcacttaag atgctattga gtgaatcagt gaggggttct tagagttagt   4920

attcattaat taaacataga atattagcta aacagttctg ggtacactgc aatgcatggt   4980

ctatggaaga ctagatgttt ggctgaagat gctttattgt tgcattatca aaatggttat   5040

agttttcaat taaaactgta attgatttct atgtataaaa cagctttgaa gttgt        5095


<210>  9374
<211>  513
<212>  PRT
<213>  Homosapiens

<400>  9374

Met Val Asp Gln Ala Ile Trp Ser Lys Lys Met Ser Asn Gly Thr Arg 
1               5                   10                  15      


Arg Ile Pro Val Ser Pro Glu Gln Ala Arg Ser Tyr Asn Lys Gln Met 
            20                  25                  30          


Arg Pro Ala Ile Leu Asp His Cys Ser Gly Asn Lys Trp Thr Asn Thr 
        35                  40                  45              


Ser His His Pro Glu Tyr Leu Val Gly Glu Glu Ala Leu Tyr Val Asn 
    50                  55                  60                  


Pro Leu Asp Cys Tyr Asn Ile His Trp Pro Ile Arg Arg Gly Gln Leu 
65                  70                  75                  80  


Asn Ile His Pro Gly Pro Gly Gly Ser Leu Thr Ala Val Leu Ala Asp 
                85                  90                  95      


Ile Glu Val Ile Trp Ser His Ala Ile Gln Lys Tyr Leu Glu Ile Pro 
            100                 105                 110         


Leu Lys Asp Leu Lys Tyr Tyr Arg Cys Ile Leu Leu Ile Pro Asp Ile 
        115                 120                 125             


Tyr Asn Lys Gln His Val Lys Glu Leu Val Asn Met Ile Leu Met Lys 
    130                 135                 140                 


Met Gly Phe Ser Gly Ile Val Val His Gln Glu Ser Val Cys Ala Thr 
145                 150                 155                 160 


Tyr Gly Ser Gly Leu Ser Ser Thr Cys Ile Val Asp Val Gly Asp Gln 
                165                 170                 175     


Lys Thr Ser Val Cys Cys Val Glu Asp Gly Val Ser His Arg Asn Thr 
            180                 185                 190         


Arg Leu Cys Leu Ala Tyr Gly Gly Ser Asp Val Ser Arg Cys Phe Tyr 
        195                 200                 205             


Trp Leu Met Gln Arg Ala Gly Phe Pro Tyr Arg Glu Cys Gln Leu Thr 
    210                 215                 220                 


Asn Lys Met Asp Cys Leu Leu Leu Gln His Leu Lys Glu Thr Phe Cys 
225                 230                 235                 240 


His Leu Asp Gln Asp Ile Ser Gly Leu Gln Asp His Glu Phe Gln Ile 
                245                 250                 255     


Arg His Pro Asp Ser Pro Ala Leu Leu Tyr Gln Phe Arg Leu Gly Asp 
            260                 265                 270         


Glu Lys Leu Gln Ala Pro Met Ala Leu Phe Tyr Pro Ala Thr Phe Gly 
        275                 280                 285             


Ile Val Gly Gln Lys Met Thr Thr Leu Gln His Arg Ser Gln Gly Asp 
    290                 295                 300                 


Pro Glu Asp Pro His Asp Glu His Tyr Leu Leu Ala Thr Gln Ser Lys 
305                 310                 315                 320 


Gln Glu Gln Ser Ala Lys Ala Thr Ala Asp Arg Lys Ser Ala Ser Lys 
                325                 330                 335     


Pro Ile Gly Phe Glu Gly Asp Leu Arg Gly Gln Ser Ser Asp Leu Pro 
            340                 345                 350         


Glu Arg Leu His Ser Gln Glu Val Asp Leu Gly Ser Ala Gln Gly Asp 
        355                 360                 365             


Gly Leu Met Ala Gly Asn Asp Ser Glu Glu Ala Leu Thr Ala Leu Met 
    370                 375                 380                 


Ser Arg Lys Thr Ala Ile Ser Leu Phe Glu Gly Lys Ala Leu Gly Leu 
385                 390                 395                 400 


Asp Lys Ala Ile Leu His Ser Ile Asp Cys Cys Ser Ser Asp Asp Thr 
                405                 410                 415     


Lys Lys Lys Met Tyr Ser Ser Ile Leu Val Val Gly Gly Gly Leu Met 
            420                 425                 430         


Phe His Lys Ala Gln Glu Phe Leu Gln His Arg Ile Leu Asn Lys Met 
        435                 440                 445             


Pro Pro Ser Phe Arg Arg Ile Ile Glu Asn Val Asp Val Ile Thr Arg 
    450                 455                 460                 


Pro Lys Asp Met Asp Pro Arg Leu Ile Ala Trp Lys Gly Gly Ala Val 
465                 470                 475                 480 


Leu Ala Cys Leu Asp Thr Thr Gln Glu Leu Trp Ile Tyr Gln Arg Glu 
                485                 490                 495     


Trp Gln Arg Phe Gly Val Arg Met Leu Arg Glu Arg Ala Ala Phe Val 
            500                 505                 510         


Trp 
    


<210>  9375
<211>  5171
<212>  DNA
<213>  Homosapiens

<400>  9375
gcgcggtggc ccttccatcc cggcagtcgt ggctgcagcg ctgaggcgag aggttggtgg     60

gtgtctccgg ccataatgac ccaggctgag aagggtgata cggagaacgg aaaggagaag    120

ggcggcgaga aggagaagga gcagcgcggc gtgaagcggc ccatcgtgcc cgcgctggtg    180

ccggagtcgc tgcaagagca aatccagagc aacttcatca ttgtcataca tccaggttca    240

acaactttaa ggattggtcg agccacagac actcttcctg ccagcattcc tcacgtcatt    300

gcccgaagac acaaacaaca agggcagccc ctatacaagg acagttggct cctaagggag    360

ggactaaata aaccagaaag taatgaacaa agacaaaatg gccttaaaat ggtggatcaa    420

gcaatatggt ctaaaaagat gtccaatggt acaagacgca ttcctgtgtc ccctgaacag    480

gcacgctcct acaataagca gatgcgacct gcaattttag atcactgttc gggaaataag    540

tggacaaaca catctcatca ccctgagtat ttagtaggag aagaggcctt gtatgttaat    600

ccactggact gttacaatat tcactggcct atcagaagag gtcagttaaa tattcaccca    660

ggccctgggg gctctcttac agctgttctg gcagatattg aagtaatatg gtctcatgcg    720

atacaaaaat acttggaaat cccactgaaa gatttaaagt attatagatg tatcttgtta    780

attcctgata tctataataa gcagcatgtg aaagaactag tgaatatgat actaatgaag    840

atgggttttt cagggattgt ggtccatcag gagtctgtgt gtgccaccta tggaagtggc    900

ttaagcagca cgtgtattgt agacgttggg gaccagaaga caagtgtatg ctgtgtggag    960

gatggggtgt ctcatcggaa tactcggctt tgtctggcat acggaggatc tgatgtgtca   1020

agatgttttt actggctaat gcagcgagct gggttccctt acagagaatg ccagttaaca   1080

aataaaatgg attgtcttct tctgcaacac cttaaagaaa ctttttgtca tttagatcag   1140

gacatctctg ggcttcagga ccatgagttt cagattcgac atcctgattc tcctgccctg   1200

ctttaccagt ttcgattagg agatgaaaaa ctgcaggctc caatggcttt gttttacccc   1260

gcaacttttg gaatcgttgg acagaaaatg acgactttgc agcacagatc tcagggcgat   1320

cctgaggatc ctcacgatga acattacctg ctggccacac agagcaaaca agaacagtct   1380

gcaaaagcta ctgctgaccg aaagtctgca tccaaaccta ttggatttga aggggatctt   1440

cgtggccagt cctctgatct tccagaaaga ctccattccc aggaggtaga tttggggtct   1500

gcacagggag atggcctgat ggccggcaac gattccgagg aggccctcac tgcactgatg   1560

tccaggaaga ctgccatctc gctgtttgaa ggaaaagccc tgggcctgga taaagccatc   1620

ctccatagca tagactgctg ttcatctgac gacaccaaaa agaagatgta cagctccatc   1680

ctagtggtgg gaggtggttt gatgtttcat aaagctcaag aatttctgca gcacagaatt   1740

ctcaacaaaa tgccaccatc cttcaggcga attattgaaa atgtggatgt gatcacaagg   1800

cctaaggaca tggacccccg gctgattgca tggaaaggag gggcagtgtt ggcttgtttg   1860

gatacaacac aggaactgtg gatttatcag cgagagtggc agcgctttgg tgtccgcatg   1920

ttacgagagc gggctgcgtt tgtgtggtga atggggagga aatgtcactg ccgaagacca   1980

aaaacaagct tcttggtata aaagactctt acagaatatg tgtattgtaa tttattgatc   2040

tggatgctta agtgtcatgg acagtaaatg aatttgaact ttatgttgag gacatgacat   2100

tggtttgaaa atataaactg cttttgagca gtttagtcag ggcatttgag aataaatagg   2160

aactttctct tcagttgtaa actctcttgc cctctctcag ggtctcataa actccccagt   2220

gatgtaaacg ttgctattga aggttctcat gtggtgaagc ccttcattta agttggcttg   2280

aatctcatca gcaggcagcc tcatgcaacc atgagggata gtatgtgacg agggagaact   2340

gtccactcat gccattttct ctcttgtcta gtatttcatt aggatctaaa gttgtctgag   2400

ttaaatgcac ttatgtgact catgtgtcct cttagaatcc caaatagggg gaaaaagttt   2460

tggtggtttt tgtttttttt ttcattttct gttggattac agaaaaagaa tgggacccat   2520

tcaggtctcg atttccaaag gtaaagatgg aaggctgggc agactggctt ttgttacctg   2580

acatgccgta gggtgagctt agaggaagaa agaaaacaat ttttatttgg ccaaaacaga   2640

acaaatgctg aaaaggaaat cttgtttttt tcctaaagcc aaatagaaat gatttgggta   2700

taatttaaga gtccttgtgt tgtacagata tggtgactga tgtagttatt aatactacca   2760

acttagtcat caagcctcaa ttttccttta cctgaaggat taagtgaaag cttttggagt   2820

tcatgatgtt cagtatgatc agttaacctt aacctctgag catcctgaag caaaatctaa   2880

ataatgcagc tattaccact ggtggtccag gctctggtga agccctctga gcccaggagg   2940

aagagaaagc attgtccaga ggtaggaaca cagtctggga gcccagagct ctgggaggag   3000

tgggaaaatg ctgcttcctg ctgcttgctt ctaggcacct gcttccgcca tctcacttac   3060

catggctaga gatgggggtg agactgggga aggacaaaag cagggaacag ataagtgatg   3120

gaaatcagaa gggaatatag aaagaactct ggatgtggag aaatgccggt acctgagcat   3180

tttgtatcaa tgggagtacc ctctgtaact gctcagtagg ttacaaatga agagtccacc   3240

agtattagaa acaatttaaa cttgccagta ccaactggga tgtgtgcctt caatttgaaa   3300

attgtatgtt ttatttttta aatttgttaa cagcattaat ttatagagta ttgatgtcat   3360

ttatgtttct gaggtgtttc aacacaattt tggatcagct gcctgtttgc aaaaacataa   3420

tatatttctg ttaaacagtt cttcacctaa cagcatattg ctcttataac tggtagagct   3480

gtttcaaagg aagttggttt ctggtccaag ttttgaccta aaccatgtcc atcttctatt   3540

accagcactt acaagcactg tgaaaactga tcatgacaaa taagtaaaat ttgctacatt   3600

aaacatattg cctcagccat tactaagcgt ccacttgtaa agctggacac agtttttact   3660

ttatgcttca ttttgatttt ttatccgtaa gacataaatt agaaggcatg aggtggccct   3720

ttaaggataa tctgcaaata tacacatttt aatagtcatc catctgaaat cgatccacat   3780

tccagagaag attcagtatt gtgctgtgtg aaataagcat tcccagaaaa aaaacattta   3840

tgctaataat acaacataac ctctgcatta aagaaaaaga tgcttttagg ccaggcgccg   3900

tggctcacac ctgtaatccc tgcactttga gaggctgagg tgggtggatc atgaggtcag   3960

gagatcaaga ccatcctggc taacagggtg aaaccccgtc tctactaaaa atataaaaag   4020

ttagctgggt gtggtggtgg gtgcctgtag tcccagctac tcaggaggct gaggcaggag   4080

aatggcgtga acccggaagg cagaggttgt agtgagccga ggtcacgcca ctgcactcca   4140

gcctgggtga cagagtgaaa ctctgtctca aaaaaaaaaa atttaaaaaa tttaaaaaag   4200

atgcttttag aagagtaaaa agttggaaga caaaatgtgc atcttttatg ttctgtcatt   4260

ctgtgggggt tttttcgttt gtttgtttta gacagggtct gctctcaccc aggatggagt   4320

gcagtggcac aatcaccgtt tactgcaccc ttgacctcca gggctcaagt gatcctccca   4380

tctcagcctc cctagtagct gggaccacag gcttacacca tcacactcag ctaatttttt   4440

aaatcttttg tagagatgga ggtctcgctt tgtgacgtag cctggtcttg agcgatcctt   4500

ttgccttggc cttgccaaag tgctgggatt ggaggcatga gccactgcac ccacccctgt   4560

tttttattta agtaaaccat tataataact catttataaa aaggttactt caagagggct   4620

ttcaacttaa gaattatttt cattttgaac atgaaaagtt aaatagtaac taagaaactg   4680

agaactctga cagtgacctc taataggtaa ctttaggcaa aagtagacaa gtttgtgggt   4740

attttgttgt tcatgttaaa aggcacctgt acaagaatca agatatgaat ctagtttgta   4800

gagggaaggt cttatgcaaa taccaaatca tacaagtggt tacacatata atagatcatt   4860

tggtccagta aaagtgggtt cagcttgttt attccctact tttgttatct taaaaacaat   4920

gattttttgc atgtaataga aggtttttca cttaagatgc tattgagtga atcagtgagg   4980

ggttcttaga gttagtattc attaattaaa catagaatat tagctaaaca gttctgggta   5040

cactgcaatg catggtctat ggaagactag atgtttggct gaagatgctt tattgttgca   5100

ttatcaaaat ggttatagtt ttcaattaaa actgtaattg atttctatgt ataaaacagc   5160

tttgaagttg t                                                        5171


<210>  9376
<211>  624
<212>  PRT
<213>  Homosapiens

<400>  9376

Met Thr Gln Ala Glu Lys Gly Asp Thr Glu Asn Gly Lys Glu Lys Gly 
1               5                   10                  15      


Gly Glu Lys Glu Lys Glu Gln Arg Gly Val Lys Arg Pro Ile Val Pro 
            20                  25                  30          


Ala Leu Val Pro Glu Ser Leu Gln Glu Gln Ile Gln Ser Asn Phe Ile 
        35                  40                  45              


Ile Val Ile His Pro Gly Ser Thr Thr Leu Arg Ile Gly Arg Ala Thr 
    50                  55                  60                  


Asp Thr Leu Pro Ala Ser Ile Pro His Val Ile Ala Arg Arg His Lys 
65                  70                  75                  80  


Gln Gln Gly Gln Pro Leu Tyr Lys Asp Ser Trp Leu Leu Arg Glu Gly 
                85                  90                  95      


Leu Asn Lys Pro Glu Ser Asn Glu Gln Arg Gln Asn Gly Leu Lys Met 
            100                 105                 110         


Val Asp Gln Ala Ile Trp Ser Lys Lys Met Ser Asn Gly Thr Arg Arg 
        115                 120                 125             


Ile Pro Val Ser Pro Glu Gln Ala Arg Ser Tyr Asn Lys Gln Met Arg 
    130                 135                 140                 


Pro Ala Ile Leu Asp His Cys Ser Gly Asn Lys Trp Thr Asn Thr Ser 
145                 150                 155                 160 


His His Pro Glu Tyr Leu Val Gly Glu Glu Ala Leu Tyr Val Asn Pro 
                165                 170                 175     


Leu Asp Cys Tyr Asn Ile His Trp Pro Ile Arg Arg Gly Gln Leu Asn 
            180                 185                 190         


Ile His Pro Gly Pro Gly Gly Ser Leu Thr Ala Val Leu Ala Asp Ile 
        195                 200                 205             


Glu Val Ile Trp Ser His Ala Ile Gln Lys Tyr Leu Glu Ile Pro Leu 
    210                 215                 220                 


Lys Asp Leu Lys Tyr Tyr Arg Cys Ile Leu Leu Ile Pro Asp Ile Tyr 
225                 230                 235                 240 


Asn Lys Gln His Val Lys Glu Leu Val Asn Met Ile Leu Met Lys Met 
                245                 250                 255     


Gly Phe Ser Gly Ile Val Val His Gln Glu Ser Val Cys Ala Thr Tyr 
            260                 265                 270         


Gly Ser Gly Leu Ser Ser Thr Cys Ile Val Asp Val Gly Asp Gln Lys 
        275                 280                 285             


Thr Ser Val Cys Cys Val Glu Asp Gly Val Ser His Arg Asn Thr Arg 
    290                 295                 300                 


Leu Cys Leu Ala Tyr Gly Gly Ser Asp Val Ser Arg Cys Phe Tyr Trp 
305                 310                 315                 320 


Leu Met Gln Arg Ala Gly Phe Pro Tyr Arg Glu Cys Gln Leu Thr Asn 
                325                 330                 335     


Lys Met Asp Cys Leu Leu Leu Gln His Leu Lys Glu Thr Phe Cys His 
            340                 345                 350         


Leu Asp Gln Asp Ile Ser Gly Leu Gln Asp His Glu Phe Gln Ile Arg 
        355                 360                 365             


His Pro Asp Ser Pro Ala Leu Leu Tyr Gln Phe Arg Leu Gly Asp Glu 
    370                 375                 380                 


Lys Leu Gln Ala Pro Met Ala Leu Phe Tyr Pro Ala Thr Phe Gly Ile 
385                 390                 395                 400 


Val Gly Gln Lys Met Thr Thr Leu Gln His Arg Ser Gln Gly Asp Pro 
                405                 410                 415     


Glu Asp Pro His Asp Glu His Tyr Leu Leu Ala Thr Gln Ser Lys Gln 
            420                 425                 430         


Glu Gln Ser Ala Lys Ala Thr Ala Asp Arg Lys Ser Ala Ser Lys Pro 
        435                 440                 445             


Ile Gly Phe Glu Gly Asp Leu Arg Gly Gln Ser Ser Asp Leu Pro Glu 
    450                 455                 460                 


Arg Leu His Ser Gln Glu Val Asp Leu Gly Ser Ala Gln Gly Asp Gly 
465                 470                 475                 480 


Leu Met Ala Gly Asn Asp Ser Glu Glu Ala Leu Thr Ala Leu Met Ser 
                485                 490                 495     


Arg Lys Thr Ala Ile Ser Leu Phe Glu Gly Lys Ala Leu Gly Leu Asp 
            500                 505                 510         


Lys Ala Ile Leu His Ser Ile Asp Cys Cys Ser Ser Asp Asp Thr Lys 
        515                 520                 525             


Lys Lys Met Tyr Ser Ser Ile Leu Val Val Gly Gly Gly Leu Met Phe 
    530                 535                 540                 


His Lys Ala Gln Glu Phe Leu Gln His Arg Ile Leu Asn Lys Met Pro 
545                 550                 555                 560 


Pro Ser Phe Arg Arg Ile Ile Glu Asn Val Asp Val Ile Thr Arg Pro 
                565                 570                 575     


Lys Asp Met Asp Pro Arg Leu Ile Ala Trp Lys Gly Gly Ala Val Leu 
            580                 585                 590         


Ala Cys Leu Asp Thr Thr Gln Glu Leu Trp Ile Tyr Gln Arg Glu Trp 
        595                 600                 605             


Gln Arg Phe Gly Val Arg Met Leu Arg Glu Arg Ala Ala Phe Val Trp 
    610                 615                 620                 


<210>  9377
<211>  519
<212>  DNA
<213>  Homosapiens

<400>  9377
gctgagtgtg atggtgtaag cctgtggtcc cagctactag ggaggctgag atgggattac     60

aggtgtgagc cacggcgcct ggcctaaaag catctttttc tttaatgcag aggttatgtt    120

gtattattag cataaatgtt ttttttctgg gaatgcttat ttcacacagc acaatactga    180

atcttctctg gaatgtggat cgatttcaga tggatgacta ttaaaatgtg tatatttgca    240

gattatcctt aaagggccac ctcatgcctt ctaatttatg tcttacggat aaaaaatcaa    300

aatgaagcat aaagtaaaaa ctgtgtccag ctttacaagt ggacgcttag taatggctga    360

ggcaatatgt ttaatgtagc aaattttact tatttgtcat gatcagtttt cacagtgctt    420

gtaagtgctg gtaatagaag atggacatgg tttaggtcaa aacttggacc agaaaccaac    480

ttcctttgaa acagctctac cagttataag agcaatatg                           519


<210>  9378
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  9378

Met Gln Arg Leu Cys Cys Ile Ile Ser Ile Asn Val Phe Phe Leu Gly 
1               5                   10                  15      


Met Leu Ile Ser His Ser Thr Ile Leu Asn Leu Leu Trp Asn Val Asp 
            20                  25                  30          


Arg Phe Gln Met Asp Asp Tyr 
        35                  


<210>  9379
<211>  3524
<212>  DNA
<213>  Homosapiens

<400>  9379
gcgcgccggg acgccgaggg ctgggaggtg cggagcgcca ggagccaggc ggagcccccg     60

cagggacacc gctccgatct cccgcacgcc ccaccgtctg gttgtgtgcg ctcctgcccg    120

ggctctggcc tcagcttccc cgaccataaa acgaccacgg ttcaacaact ttaaggattg    180

gtcgagccac agacactctt cctgccagca ttcctcacgt cattgcccga agacacaaac    240

aacaagggca gcccctatac aaggacagtt ggctcctaag ggagggacta aataaaccag    300

aaagtaatga acaaagacaa aatggcctta aaatggtgga tcaagcaata tggtctaaaa    360

agatgtccaa tggtacaaga cgcattcctg tgtcccctga acaggcacgc tcctacaata    420

agcagatgcg acctgcaatt ttagatcact gttcgggaaa taagtggaca aacacatctc    480

atcaccctga gtatttagta ggagaagagg ccttgtatgt taatccactg gactgttaca    540

atattcactg gcctatcaga agaggtcagt taaatattca cccaggccct gggggctctc    600

ttacagctgt tctggcagat attgaagtaa tatggtctca tgcgatacaa aaatacttgg    660

aaatcccact gaaagattta aagtattata gatgtatctt gttaattcct gatatctata    720

ataagcagca tgtgaaagaa ctagtgaata tgatactaat gaagatgggt ttttcaggga    780

ttgtggtcca tcaggagtct gtgtgtgcca cctatggaag tggcttaagc agcacgtgta    840

ttgtagacgt tggggaccag aagacaagtg tatgctgtgt ggaggatggg gtgtctcatc    900

ggaatactcg gctttgtctg gcatacggag gatctgatgt gtcaagatgt ttttactggc    960

taatgcagcg agctgggttc ccttacagag aatgccagtt aacaaataaa atggattgtc   1020

ttcttctgca acaccttaaa gaaacttttt gtcatttaga tcaggacatc tctgggcttc   1080

aggaccatga gtttcagatt cgacatcctg attctcctgc cctgctttac cagtttcgat   1140

taggagatga aaaactgcag gctccaatgg ctttgtttta ccccgcaact tttggaatcg   1200

ttggacagaa aatgacgact ttgcagcaca gatctcaggg cgatcctgag gatcctcacg   1260

atgaacatta cctgctggcc acacagagca aacaagaaca gtctgcaaaa gctactgctg   1320

accgaaagtc tgcatccaaa cctattggat ttgaagggga tcttcgtggc cagtcctctg   1380

atcttccaga aagactccat tcccaggagg tagatttggg gtctgcacag ggagatggcc   1440

tgatggccgg caacgattcc gaggaggccc tcactgcact gatgtccagg aagactgcca   1500

tctcgctgtt tgaaggaaaa gccctgggcc tggataaagc catcctccat agcatagact   1560

gctgttcatc tgacgacacc aaaaagaaga tgtacagctc catcctagtg gtgggaggtg   1620

gtttgatgtt tcataaagct caagaatttc tgcagcacag aattctcaac aaaatgccac   1680

catccttcag gcgaattatt gaaaatgtgg atgtgatcac aaggcctaag gacatggacc   1740

cccggctgat tgcatggaaa ggaggggcag tgttggcttg tttggataca acacaggaac   1800

tgtggattta tcagcgagag tggcagcgct ttggtgtccg catgttacga gagcgggctg   1860

cgtttgtgtg gtgaatgggg aggaaatgtc actgccgaag accaaaaaca agcttcttgg   1920

tataaaagac tcttacagaa tatgtgtatt gtaatttatt gatctggatg cttaagtgtc   1980

atggacagta aatgaatttg aactttatgt tgaggacatg acattggttt gaaaatataa   2040

actgcttttg agcagtttag tcagggcatt tgagaataaa taggaacttt ctcttcagtt   2100

gtaaactctc ttgccctctc tcagggtctc ataaactccc cagtgatgta aacgttgcta   2160

ttgaaggttc tcatgtggtg aagcccttca tttaagttgg cttgaatctc atcagcaggc   2220

agcctcatgc aaccatgagg gatagtatgt gacgagggag aactgtccac tcatgccatt   2280

ttctctcttg tctagtattt cattaggatc taaagttgtc tgagttaaat gcacttatgt   2340

gactcatgtg tcctcttaga atcccaaata gggggaaaaa gttttggtgg tttttgtttt   2400

ttttttcatt ttctgttgga ttacagaaaa agaatgggac ccattcaggt ctcgatttcc   2460

aaaggtaaag atggaaggct gggcagactg gcttttgtta cctgacatgc cgtagggtga   2520

gcttagagga agaaagaaaa caatttttat ttggccaaaa cagaacaaat gctgaaaagg   2580

aaatcttgtt tttttcctaa agccaaatag aaatgatttg ggtataattt aagagtcctt   2640

gtgttgtaca gatatggtga ctgatgtagt tattaatact accaacttag tcatcaagcc   2700

tcaattttcc tttacctgaa ggattaagtg aaagcttttg gagttcatga tgttcagtat   2760

gatcagttaa ccttaacctc tgagcatcct gaagcaaaat ctaaataatg cagctattac   2820

cactggtggt ccaggctctg gtgaagccct ctgagcccag gaggaagaga aagcattgtc   2880

cagaggtagg aacacagtct gggagcccag agctctggga ggagtgggaa aatgctgctt   2940

cctgctgctt gcttctaggc acctgcttcc gccatctcac ttaccatggc tagagatggg   3000

ggtgagactg gggaaggaca aaagcaggga acagataagt gatggaaatc agaagggaat   3060

atagaaagaa ctctggatgt ggagaaatgc cggtacctga gcattttgta tcaatgggag   3120

taccctctgt aactgctcag taggttacaa atgaagagtc caccagtatt agaaacaatt   3180

taaacttgcc agtaccaact gggatgtgtg ccttcaattt gaaaattgta tgttttattt   3240

tttaaatttg ttaacagcat taatttatag agtattgatg tcatttatgt ttctgaggtg   3300

tttcaacaca attttggatc agctgcctgt ttgcaaaaac ataatatatt tctgttaaac   3360

agttcttcac ctaacagcat attgctctta taactggtag agctgtttca aaggaagttg   3420

gtttctggtc caagttttga cctaaaccat gtccatcttc tattaccagc acttacaagc   3480

actgtgaaaa ctgatcatga caaataagta aaatttgcta catt                    3524


<210>  9380
<211>  513
<212>  PRT
<213>  Homosapiens

<400>  9380

Met Val Asp Gln Ala Ile Trp Ser Lys Lys Met Ser Asn Gly Thr Arg 
1               5                   10                  15      


Arg Ile Pro Val Ser Pro Glu Gln Ala Arg Ser Tyr Asn Lys Gln Met 
            20                  25                  30          


Arg Pro Ala Ile Leu Asp His Cys Ser Gly Asn Lys Trp Thr Asn Thr 
        35                  40                  45              


Ser His His Pro Glu Tyr Leu Val Gly Glu Glu Ala Leu Tyr Val Asn 
    50                  55                  60                  


Pro Leu Asp Cys Tyr Asn Ile His Trp Pro Ile Arg Arg Gly Gln Leu 
65                  70                  75                  80  


Asn Ile His Pro Gly Pro Gly Gly Ser Leu Thr Ala Val Leu Ala Asp 
                85                  90                  95      


Ile Glu Val Ile Trp Ser His Ala Ile Gln Lys Tyr Leu Glu Ile Pro 
            100                 105                 110         


Leu Lys Asp Leu Lys Tyr Tyr Arg Cys Ile Leu Leu Ile Pro Asp Ile 
        115                 120                 125             


Tyr Asn Lys Gln His Val Lys Glu Leu Val Asn Met Ile Leu Met Lys 
    130                 135                 140                 


Met Gly Phe Ser Gly Ile Val Val His Gln Glu Ser Val Cys Ala Thr 
145                 150                 155                 160 


Tyr Gly Ser Gly Leu Ser Ser Thr Cys Ile Val Asp Val Gly Asp Gln 
                165                 170                 175     


Lys Thr Ser Val Cys Cys Val Glu Asp Gly Val Ser His Arg Asn Thr 
            180                 185                 190         


Arg Leu Cys Leu Ala Tyr Gly Gly Ser Asp Val Ser Arg Cys Phe Tyr 
        195                 200                 205             


Trp Leu Met Gln Arg Ala Gly Phe Pro Tyr Arg Glu Cys Gln Leu Thr 
    210                 215                 220                 


Asn Lys Met Asp Cys Leu Leu Leu Gln His Leu Lys Glu Thr Phe Cys 
225                 230                 235                 240 


His Leu Asp Gln Asp Ile Ser Gly Leu Gln Asp His Glu Phe Gln Ile 
                245                 250                 255     


Arg His Pro Asp Ser Pro Ala Leu Leu Tyr Gln Phe Arg Leu Gly Asp 
            260                 265                 270         


Glu Lys Leu Gln Ala Pro Met Ala Leu Phe Tyr Pro Ala Thr Phe Gly 
        275                 280                 285             


Ile Val Gly Gln Lys Met Thr Thr Leu Gln His Arg Ser Gln Gly Asp 
    290                 295                 300                 


Pro Glu Asp Pro His Asp Glu His Tyr Leu Leu Ala Thr Gln Ser Lys 
305                 310                 315                 320 


Gln Glu Gln Ser Ala Lys Ala Thr Ala Asp Arg Lys Ser Ala Ser Lys 
                325                 330                 335     


Pro Ile Gly Phe Glu Gly Asp Leu Arg Gly Gln Ser Ser Asp Leu Pro 
            340                 345                 350         


Glu Arg Leu His Ser Gln Glu Val Asp Leu Gly Ser Ala Gln Gly Asp 
        355                 360                 365             


Gly Leu Met Ala Gly Asn Asp Ser Glu Glu Ala Leu Thr Ala Leu Met 
    370                 375                 380                 


Ser Arg Lys Thr Ala Ile Ser Leu Phe Glu Gly Lys Ala Leu Gly Leu 
385                 390                 395                 400 


Asp Lys Ala Ile Leu His Ser Ile Asp Cys Cys Ser Ser Asp Asp Thr 
                405                 410                 415     


Lys Lys Lys Met Tyr Ser Ser Ile Leu Val Val Gly Gly Gly Leu Met 
            420                 425                 430         


Phe His Lys Ala Gln Glu Phe Leu Gln His Arg Ile Leu Asn Lys Met 
        435                 440                 445             


Pro Pro Ser Phe Arg Arg Ile Ile Glu Asn Val Asp Val Ile Thr Arg 
    450                 455                 460                 


Pro Lys Asp Met Asp Pro Arg Leu Ile Ala Trp Lys Gly Gly Ala Val 
465                 470                 475                 480 


Leu Ala Cys Leu Asp Thr Thr Gln Glu Leu Trp Ile Tyr Gln Arg Glu 
                485                 490                 495     


Trp Gln Arg Phe Gly Val Arg Met Leu Arg Glu Arg Ala Ala Phe Val 
            500                 505                 510         


Trp 
    


<210>  9381
<211>  3600
<212>  DNA
<213>  Homosapiens

<400>  9381
gcgcggtggc ccttccatcc cggcagtcgt ggctgcagcg ctgaggcgag aggttggtgg     60

gtgtctccgg ccataatgac ccaggctgag aagggtgata cggagaacgg aaaggagaag    120

ggcggcgaga aggagaagga gcagcgcggc gtgaagcggc ccatcgtgcc cgcgctggtg    180

ccggagtcgc tgcaagagca aatccagagc aacttcatca ttgtcataca tccaggttca    240

acaactttaa ggattggtcg agccacagac actcttcctg ccagcattcc tcacgtcatt    300

gcccgaagac acaaacaaca agggcagccc ctatacaagg acagttggct cctaagggag    360

ggactaaata aaccagaaag taatgaacaa agacaaaatg gccttaaaat ggtggatcaa    420

gcaatatggt ctaaaaagat gtccaatggt acaagacgca ttcctgtgtc ccctgaacag    480

gcacgctcct acaataagca gatgcgacct gcaattttag atcactgttc gggaaataag    540

tggacaaaca catctcatca ccctgagtat ttagtaggag aagaggcctt gtatgttaat    600

ccactggact gttacaatat tcactggcct atcagaagag gtcagttaaa tattcaccca    660

ggccctgggg gctctcttac agctgttctg gcagatattg aagtaatatg gtctcatgcg    720

atacaaaaat acttggaaat cccactgaaa gatttaaagt attatagatg tatcttgtta    780

attcctgata tctataataa gcagcatgtg aaagaactag tgaatatgat actaatgaag    840

atgggttttt cagggattgt ggtccatcag gagtctgtgt gtgccaccta tggaagtggc    900

ttaagcagca cgtgtattgt agacgttggg gaccagaaga caagtgtatg ctgtgtggag    960

gatggggtgt ctcatcggaa tactcggctt tgtctggcat acggaggatc tgatgtgtca   1020

agatgttttt actggctaat gcagcgagct gggttccctt acagagaatg ccagttaaca   1080

aataaaatgg attgtcttct tctgcaacac cttaaagaaa ctttttgtca tttagatcag   1140

gacatctctg ggcttcagga ccatgagttt cagattcgac atcctgattc tcctgccctg   1200

ctttaccagt ttcgattagg agatgaaaaa ctgcaggctc caatggcttt gttttacccc   1260

gcaacttttg gaatcgttgg acagaaaatg acgactttgc agcacagatc tcagggcgat   1320

cctgaggatc ctcacgatga acattacctg ctggccacac agagcaaaca agaacagtct   1380

gcaaaagcta ctgctgaccg aaagtctgca tccaaaccta ttggatttga aggggatctt   1440

cgtggccagt cctctgatct tccagaaaga ctccattccc aggaggtaga tttggggtct   1500

gcacagggag atggcctgat ggccggcaac gattccgagg aggccctcac tgcactgatg   1560

tccaggaaga ctgccatctc gctgtttgaa ggaaaagccc tgggcctgga taaagccatc   1620

ctccatagca tagactgctg ttcatctgac gacaccaaaa agaagatgta cagctccatc   1680

ctagtggtgg gaggtggttt gatgtttcat aaagctcaag aatttctgca gcacagaatt   1740

ctcaacaaaa tgccaccatc cttcaggcga attattgaaa atgtggatgt gatcacaagg   1800

cctaaggaca tggacccccg gctgattgca tggaaaggag gggcagtgtt ggcttgtttg   1860

gatacaacac aggaactgtg gatttatcag cgagagtggc agcgctttgg tgtccgcatg   1920

ttacgagagc gggctgcgtt tgtgtggtga atggggagga aatgtcactg ccgaagacca   1980

aaaacaagct tcttggtata aaagactctt acagaatatg tgtattgtaa tttattgatc   2040

tggatgctta agtgtcatgg acagtaaatg aatttgaact ttatgttgag gacatgacat   2100

tggtttgaaa atataaactg cttttgagca gtttagtcag ggcatttgag aataaatagg   2160

aactttctct tcagttgtaa actctcttgc cctctctcag ggtctcataa actccccagt   2220

gatgtaaacg ttgctattga aggttctcat gtggtgaagc ccttcattta agttggcttg   2280

aatctcatca gcaggcagcc tcatgcaacc atgagggata gtatgtgacg agggagaact   2340

gtccactcat gccattttct ctcttgtcta gtatttcatt aggatctaaa gttgtctgag   2400

ttaaatgcac ttatgtgact catgtgtcct cttagaatcc caaatagggg gaaaaagttt   2460

tggtggtttt tgtttttttt ttcattttct gttggattac agaaaaagaa tgggacccat   2520

tcaggtctcg atttccaaag gtaaagatgg aaggctgggc agactggctt ttgttacctg   2580

acatgccgta gggtgagctt agaggaagaa agaaaacaat ttttatttgg ccaaaacaga   2640

acaaatgctg aaaaggaaat cttgtttttt tcctaaagcc aaatagaaat gatttgggta   2700

taatttaaga gtccttgtgt tgtacagata tggtgactga tgtagttatt aatactacca   2760

acttagtcat caagcctcaa ttttccttta cctgaaggat taagtgaaag cttttggagt   2820

tcatgatgtt cagtatgatc agttaacctt aacctctgag catcctgaag caaaatctaa   2880

ataatgcagc tattaccact ggtggtccag gctctggtga agccctctga gcccaggagg   2940

aagagaaagc attgtccaga ggtaggaaca cagtctggga gcccagagct ctgggaggag   3000

tgggaaaatg ctgcttcctg ctgcttgctt ctaggcacct gcttccgcca tctcacttac   3060

catggctaga gatgggggtg agactgggga aggacaaaag cagggaacag ataagtgatg   3120

gaaatcagaa gggaatatag aaagaactct ggatgtggag aaatgccggt acctgagcat   3180

tttgtatcaa tgggagtacc ctctgtaact gctcagtagg ttacaaatga agagtccacc   3240

agtattagaa acaatttaaa cttgccagta ccaactggga tgtgtgcctt caatttgaaa   3300

attgtatgtt ttatttttta aatttgttaa cagcattaat ttatagagta ttgatgtcat   3360

ttatgtttct gaggtgtttc aacacaattt tggatcagct gcctgtttgc aaaaacataa   3420

tatatttctg ttaaacagtt cttcacctaa cagcatattg ctcttataac tggtagagct   3480

gtttcaaagg aagttggttt ctggtccaag ttttgaccta aaccatgtcc atcttctatt   3540

accagcactt acaagcactg tgaaaactga tcatgacaaa taagtaaaat ttgctacatt   3600


<210>  9382
<211>  624
<212>  PRT
<213>  Homosapiens

<400>  9382

Met Thr Gln Ala Glu Lys Gly Asp Thr Glu Asn Gly Lys Glu Lys Gly 
1               5                   10                  15      


Gly Glu Lys Glu Lys Glu Gln Arg Gly Val Lys Arg Pro Ile Val Pro 
            20                  25                  30          


Ala Leu Val Pro Glu Ser Leu Gln Glu Gln Ile Gln Ser Asn Phe Ile 
        35                  40                  45              


Ile Val Ile His Pro Gly Ser Thr Thr Leu Arg Ile Gly Arg Ala Thr 
    50                  55                  60                  


Asp Thr Leu Pro Ala Ser Ile Pro His Val Ile Ala Arg Arg His Lys 
65                  70                  75                  80  


Gln Gln Gly Gln Pro Leu Tyr Lys Asp Ser Trp Leu Leu Arg Glu Gly 
                85                  90                  95      


Leu Asn Lys Pro Glu Ser Asn Glu Gln Arg Gln Asn Gly Leu Lys Met 
            100                 105                 110         


Val Asp Gln Ala Ile Trp Ser Lys Lys Met Ser Asn Gly Thr Arg Arg 
        115                 120                 125             


Ile Pro Val Ser Pro Glu Gln Ala Arg Ser Tyr Asn Lys Gln Met Arg 
    130                 135                 140                 


Pro Ala Ile Leu Asp His Cys Ser Gly Asn Lys Trp Thr Asn Thr Ser 
145                 150                 155                 160 


His His Pro Glu Tyr Leu Val Gly Glu Glu Ala Leu Tyr Val Asn Pro 
                165                 170                 175     


Leu Asp Cys Tyr Asn Ile His Trp Pro Ile Arg Arg Gly Gln Leu Asn 
            180                 185                 190         


Ile His Pro Gly Pro Gly Gly Ser Leu Thr Ala Val Leu Ala Asp Ile 
        195                 200                 205             


Glu Val Ile Trp Ser His Ala Ile Gln Lys Tyr Leu Glu Ile Pro Leu 
    210                 215                 220                 


Lys Asp Leu Lys Tyr Tyr Arg Cys Ile Leu Leu Ile Pro Asp Ile Tyr 
225                 230                 235                 240 


Asn Lys Gln His Val Lys Glu Leu Val Asn Met Ile Leu Met Lys Met 
                245                 250                 255     


Gly Phe Ser Gly Ile Val Val His Gln Glu Ser Val Cys Ala Thr Tyr 
            260                 265                 270         


Gly Ser Gly Leu Ser Ser Thr Cys Ile Val Asp Val Gly Asp Gln Lys 
        275                 280                 285             


Thr Ser Val Cys Cys Val Glu Asp Gly Val Ser His Arg Asn Thr Arg 
    290                 295                 300                 


Leu Cys Leu Ala Tyr Gly Gly Ser Asp Val Ser Arg Cys Phe Tyr Trp 
305                 310                 315                 320 


Leu Met Gln Arg Ala Gly Phe Pro Tyr Arg Glu Cys Gln Leu Thr Asn 
                325                 330                 335     


Lys Met Asp Cys Leu Leu Leu Gln His Leu Lys Glu Thr Phe Cys His 
            340                 345                 350         


Leu Asp Gln Asp Ile Ser Gly Leu Gln Asp His Glu Phe Gln Ile Arg 
        355                 360                 365             


His Pro Asp Ser Pro Ala Leu Leu Tyr Gln Phe Arg Leu Gly Asp Glu 
    370                 375                 380                 


Lys Leu Gln Ala Pro Met Ala Leu Phe Tyr Pro Ala Thr Phe Gly Ile 
385                 390                 395                 400 


Val Gly Gln Lys Met Thr Thr Leu Gln His Arg Ser Gln Gly Asp Pro 
                405                 410                 415     


Glu Asp Pro His Asp Glu His Tyr Leu Leu Ala Thr Gln Ser Lys Gln 
            420                 425                 430         


Glu Gln Ser Ala Lys Ala Thr Ala Asp Arg Lys Ser Ala Ser Lys Pro 
        435                 440                 445             


Ile Gly Phe Glu Gly Asp Leu Arg Gly Gln Ser Ser Asp Leu Pro Glu 
    450                 455                 460                 


Arg Leu His Ser Gln Glu Val Asp Leu Gly Ser Ala Gln Gly Asp Gly 
465                 470                 475                 480 


Leu Met Ala Gly Asn Asp Ser Glu Glu Ala Leu Thr Ala Leu Met Ser 
                485                 490                 495     


Arg Lys Thr Ala Ile Ser Leu Phe Glu Gly Lys Ala Leu Gly Leu Asp 
            500                 505                 510         


Lys Ala Ile Leu His Ser Ile Asp Cys Cys Ser Ser Asp Asp Thr Lys 
        515                 520                 525             


Lys Lys Met Tyr Ser Ser Ile Leu Val Val Gly Gly Gly Leu Met Phe 
    530                 535                 540                 


His Lys Ala Gln Glu Phe Leu Gln His Arg Ile Leu Asn Lys Met Pro 
545                 550                 555                 560 


Pro Ser Phe Arg Arg Ile Ile Glu Asn Val Asp Val Ile Thr Arg Pro 
                565                 570                 575     


Lys Asp Met Asp Pro Arg Leu Ile Ala Trp Lys Gly Gly Ala Val Leu 
            580                 585                 590         


Ala Cys Leu Asp Thr Thr Gln Glu Leu Trp Ile Tyr Gln Arg Glu Trp 
        595                 600                 605             


Gln Arg Phe Gly Val Arg Met Leu Arg Glu Arg Ala Ala Phe Val Trp 
    610                 615                 620                 


<210>  9383
<211>  688
<212>  DNA
<213>  Homosapiens

<400>  9383
cgtagggttc ccctggctgc agtgtggagg gtgggctgga gggaaatctt tgagaaggct     60

attgcacttg ctcaagcaag aggtgttggt ggcttggcct agaattatgg atgtggagaa    120

aaaagcatgg aggatgtcaa ctgtcttttc agcatctgac gacaccaaaa agaagatgta    180

cagctccatc ctagtggtgg gaggtggttt gatgtttcat aaagctcaag aatttctgca    240

gcacagaatt ctcaacaaaa tgccaccatc cttcaggcga attattgaaa atgtggatgt    300

gatcacaagg cctaaggaca tggacccccg gctgattgca tggaaaggag gggcagtgtt    360

ggcttgtttg gatacaacac aggaactgtg gatttatcag cgagagtggc agcgctttgg    420

tgtccgcatg ttacgagagc gggctgcgtt tgtgtggtga atggggagga aatgtcactg    480

ccgaagacca aaaacaagct tcttggtata aaagactctt acagaatatg tgtattgtaa    540

tttattgatc tggatgctta agtgtcatgg acagtaaatg aatttgaact ttatgttgag    600

gacatgacat tggtttgaaa atataaactg cttttgagca gtttagtcag ggcatttgag    660

aataaatagg aactttctct tcagttgt                                       688


<210>  9384
<211>  117
<212>  PRT
<213>  Homosapiens

<400>  9384

Met Asp Val Glu Lys Lys Ala Trp Arg Met Ser Thr Val Phe Ser Ala 
1               5                   10                  15      


Ser Asp Asp Thr Lys Lys Lys Met Tyr Ser Ser Ile Leu Val Val Gly 
            20                  25                  30          


Gly Gly Leu Met Phe His Lys Ala Gln Glu Phe Leu Gln His Arg Ile 
        35                  40                  45              


Leu Asn Lys Met Pro Pro Ser Phe Arg Arg Ile Ile Glu Asn Val Asp 
    50                  55                  60                  


Val Ile Thr Arg Pro Lys Asp Met Asp Pro Arg Leu Ile Ala Trp Lys 
65                  70                  75                  80  


Gly Gly Ala Val Leu Ala Cys Leu Asp Thr Thr Gln Glu Leu Trp Ile 
                85                  90                  95      


Tyr Gln Arg Glu Trp Gln Arg Phe Gly Val Arg Met Leu Arg Glu Arg 
            100                 105                 110         


Ala Ala Phe Val Trp 
        115         


<210>  9385
<211>  2102
<212>  DNA
<213>  Homosapiens

<400>  9385
gcgcgccggg acgccgaggg ctgggaggtg cggagcgcca ggagccaggc ggagcccccg     60

cagggacacc gctccgatct cccgcacgcc ccaccgtctg gttgtgtgcg ctcctgcccg    120

ggctctggcc tcagcttccc cgaccataaa acgaccacgg ttcaacaact ttaaggattg    180

gtcgagccac agacactctt cctgccagca ttcctcacgt cattgcccga agacacaaac    240

aacaagggca gcccctatac aaggacagtt ggctcctaag ggagggacta aataaaccag    300

aaagtaatga acaaagacaa aatggcctta aaatggtgga tcaagcaata tggtctaaaa    360

agatgtccaa tggtacaaga cgcattcctg tgtcccctga acaggcacgc tcctacaata    420

agcagatgcg acctgcaatt ttagatcact gttcgggaaa taagtggaca aacacatctc    480

atcaccctga gtatttagta ggagaagagg ccttgtatgt taatccactg gactgttaca    540

atattcactg gcctatcaga agaggtcagt taaatattca cccaggccct gggggctctc    600

ttacagctgt tctggcagat attgaagtaa tatggtctca tgcgatacaa aaatacttgg    660

aaatcccact gaaagattta aagtattata gatgtatctt gttaattcct gatatctata    720

ataagcagca tgtgaaagaa ctagtgaata tgatactaat gaagatgggt ttttcaggga    780

ttgtggtcca tcaggagtct gtgtgtgcca cctatggaag tggcttaagc agcacgtgta    840

ttgtagacgt tggggaccag aagacaagtg tatgctgtgt ggaggatggg gtgtctcatc    900

ggaatactcg gctttgtctg gcatacggag gatctgatgt gtcaagatgt ttttactggc    960

taatgcagcg agctgggttc ccttacagag aatgccagtt aacaaataaa atggattgtc   1020

ttcttctgca acaccttaaa gaaacttttt gtcatttaga tcaggacatc tctgggcttc   1080

aggaccatga gtttcagatt cgacatcctg attctcctgc cctgctttac cagtttcgat   1140

taggagatga aaaactgcag gctccaatgg ctttgtttta ccccgcaact tttggaatcg   1200

ttggacagaa aatgacgact ttgcagcaca gatctcaggg cgatcctgag gatcctcacg   1260

atgaacatta cctgctggcc acacagagca aacaagaaca gtctgcaaaa gctactgctg   1320

accgaaagtc tgcatccaaa cctattggat ttgaagggga tcttcgtggc cagtcctctg   1380

atcttccaga aagactccat tcccaggagg tagatttggg gtctgcacag ggagatggcc   1440

tgatggccgg caacgattcc gaggaggccc tcactgcact gatgtccagg aagactgcca   1500

tctcgctgtt tgaaggaaaa gccctgggcc tggataaagc catcctccat agcatagact   1560

gctgttcatc tgacgacacc aaaaagaaga tgtacagctc catcctagtg gtgggaggtg   1620

gtttgatgtt tcataaagct caagaatttc tgcagcacag aattctcaac aaaatgccac   1680

catccttcag gcgaattatt gaaaatgtgg atgtgatcac aaggcctaag gacatggacc   1740

cccggctgat tgcatggaaa ggaggggcag tgttggcttg tttggataca acacaggaac   1800

tgtggattta tcagcgagag tggcagcgct ttggtgtccg catgttacga gagcgggctg   1860

cgtttgtgtg gtgaatgggg aggaaatgtc actgccgaag accaaaaaca agcttcttgg   1920

tataaaagac tcttacagaa tatgtgtatt gtaatttatt gatctggatg cttaagtgtc   1980

atggacagta aatgaatttg aactttatgt tgaggacatg acattggttt gaaaatataa   2040

actgcttttg agcagtttag tcagggcatt tgagaataaa taggaacttt ctcttcagtt   2100

gt                                                                  2102


<210>  9386
<211>  513
<212>  PRT
<213>  Homosapiens

<400>  9386

Met Val Asp Gln Ala Ile Trp Ser Lys Lys Met Ser Asn Gly Thr Arg 
1               5                   10                  15      


Arg Ile Pro Val Ser Pro Glu Gln Ala Arg Ser Tyr Asn Lys Gln Met 
            20                  25                  30          


Arg Pro Ala Ile Leu Asp His Cys Ser Gly Asn Lys Trp Thr Asn Thr 
        35                  40                  45              


Ser His His Pro Glu Tyr Leu Val Gly Glu Glu Ala Leu Tyr Val Asn 
    50                  55                  60                  


Pro Leu Asp Cys Tyr Asn Ile His Trp Pro Ile Arg Arg Gly Gln Leu 
65                  70                  75                  80  


Asn Ile His Pro Gly Pro Gly Gly Ser Leu Thr Ala Val Leu Ala Asp 
                85                  90                  95      


Ile Glu Val Ile Trp Ser His Ala Ile Gln Lys Tyr Leu Glu Ile Pro 
            100                 105                 110         


Leu Lys Asp Leu Lys Tyr Tyr Arg Cys Ile Leu Leu Ile Pro Asp Ile 
        115                 120                 125             


Tyr Asn Lys Gln His Val Lys Glu Leu Val Asn Met Ile Leu Met Lys 
    130                 135                 140                 


Met Gly Phe Ser Gly Ile Val Val His Gln Glu Ser Val Cys Ala Thr 
145                 150                 155                 160 


Tyr Gly Ser Gly Leu Ser Ser Thr Cys Ile Val Asp Val Gly Asp Gln 
                165                 170                 175     


Lys Thr Ser Val Cys Cys Val Glu Asp Gly Val Ser His Arg Asn Thr 
            180                 185                 190         


Arg Leu Cys Leu Ala Tyr Gly Gly Ser Asp Val Ser Arg Cys Phe Tyr 
        195                 200                 205             


Trp Leu Met Gln Arg Ala Gly Phe Pro Tyr Arg Glu Cys Gln Leu Thr 
    210                 215                 220                 


Asn Lys Met Asp Cys Leu Leu Leu Gln His Leu Lys Glu Thr Phe Cys 
225                 230                 235                 240 


His Leu Asp Gln Asp Ile Ser Gly Leu Gln Asp His Glu Phe Gln Ile 
                245                 250                 255     


Arg His Pro Asp Ser Pro Ala Leu Leu Tyr Gln Phe Arg Leu Gly Asp 
            260                 265                 270         


Glu Lys Leu Gln Ala Pro Met Ala Leu Phe Tyr Pro Ala Thr Phe Gly 
        275                 280                 285             


Ile Val Gly Gln Lys Met Thr Thr Leu Gln His Arg Ser Gln Gly Asp 
    290                 295                 300                 


Pro Glu Asp Pro His Asp Glu His Tyr Leu Leu Ala Thr Gln Ser Lys 
305                 310                 315                 320 


Gln Glu Gln Ser Ala Lys Ala Thr Ala Asp Arg Lys Ser Ala Ser Lys 
                325                 330                 335     


Pro Ile Gly Phe Glu Gly Asp Leu Arg Gly Gln Ser Ser Asp Leu Pro 
            340                 345                 350         


Glu Arg Leu His Ser Gln Glu Val Asp Leu Gly Ser Ala Gln Gly Asp 
        355                 360                 365             


Gly Leu Met Ala Gly Asn Asp Ser Glu Glu Ala Leu Thr Ala Leu Met 
    370                 375                 380                 


Ser Arg Lys Thr Ala Ile Ser Leu Phe Glu Gly Lys Ala Leu Gly Leu 
385                 390                 395                 400 


Asp Lys Ala Ile Leu His Ser Ile Asp Cys Cys Ser Ser Asp Asp Thr 
                405                 410                 415     


Lys Lys Lys Met Tyr Ser Ser Ile Leu Val Val Gly Gly Gly Leu Met 
            420                 425                 430         


Phe His Lys Ala Gln Glu Phe Leu Gln His Arg Ile Leu Asn Lys Met 
        435                 440                 445             


Pro Pro Ser Phe Arg Arg Ile Ile Glu Asn Val Asp Val Ile Thr Arg 
    450                 455                 460                 


Pro Lys Asp Met Asp Pro Arg Leu Ile Ala Trp Lys Gly Gly Ala Val 
465                 470                 475                 480 


Leu Ala Cys Leu Asp Thr Thr Gln Glu Leu Trp Ile Tyr Gln Arg Glu 
                485                 490                 495     


Trp Gln Arg Phe Gly Val Arg Met Leu Arg Glu Arg Ala Ala Phe Val 
            500                 505                 510         


Trp 
    


<210>  9387
<211>  1520
<212>  DNA
<213>  Homosapiens

<400>  9387
ctcatcttta tattcacgaa aaagcaatct gaagaaaaca aataaaagcc tgtgtattta     60

gcactgttag tgtcaccttt tcaacttctg aaacactgtt cattgttaac tttttctcat    120

ttataaatca ctgtatttat tttagtagta tgcatagcat atctgtgctc ttgaattaat    180

ttttatcttt aacatatttg tctcatcaat ctttaataca ctgtgtctaa tttgctacca    240

aatgtaatta tcagggtatt tataaaacca tagctaacaa aactgagcta caaaatgaaa    300

atttactaaa tagtttttaa aatcatggac ttcagcctgg cgcggtggct catgcctgta    360

atcccagcac tgtgggaggc tgaggcgggc agatcgccta agttcacgag tttgagacca    420

gcctgcagca tgacgaaacc taaaataaca aaaattagcc aggcgtggta gagtgcacct    480

gtaatccctg ctactcagga ggcggaggca ggagaatcgc ttcaacccgg gaggcggagg    540

ttgctgtgag catgccactg cactcctgcc taggcaacag agtgagaccc tgtctcaaaa    600

aaataaataa aaccatgggc ttccatgcta tcttgacaaa tttgcactct atagcatcac    660

tcaaaatact gcctattggc tttaaactcc atctgaatac tgataacttt cacattcttt    720

cactagagtg gaagctctga gactaggaat tttgttgtct ttaccccagt cctttgaata    780

gtgactacat gtaagatagt catgtagtat ttattggaaa taaatattta ttggaaaaac    840

gaaaacagat aattcctctt ctggtgttta acaggctttg aaaccaagtg ttcaggtgaa    900

agccttttta tattgattta tcagcattta ttcaaccccg tttgtcggga aatgggatta    960

cacgtgtgag ccacaatgcc cagcctgtaa atttttacac attttaaatt ctgacaaagt   1020

gagggatatg tataatgtat acatatatac aaagtgaggt aaatgtataa tgacatttgc   1080

attatacaga tacatgcaag ggttcagtaa agtttggcag cttcctagat tgtattgcca   1140

gtgaatggca gaggcattat taaacctcca ccttacccta tagcggggag accatggcag   1200

agtctcagta ggtggttgat tgttgttact gatggctctt cctgagcatg tgaaccatgg   1260

tcctcttctg cctcctagca ctgctgctgc aggacttgtt cctcgggtct tatcccagag   1320

ttctggctgc atttgacatt caggtattct tctttgcact tcagatagaa tgtaaaacac   1380

aggttcttga gtactttatg cttaactctt gtctttgcta ctcaatagct tatgatcttg   1440

agtgaattat gccattttat cccacttcac tcacctgtaa aacggggatt aaatttttac   1500

ctccaagagt tctttattta                                               1520


<210>  9388
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  9388

Met Pro Leu His Ser Cys Leu Gly Asn Arg Val Arg Pro Cys Leu Lys 
1               5                   10                  15      


Lys Ile Asn Lys Thr Met Gly Phe His Ala Ile Leu Thr Asn Leu His 
            20                  25                  30          


Ser Ile Ala Ser Leu Lys Ile Leu Pro Ile Gly Phe Lys Leu His Leu 
        35                  40                  45              


Asn Thr Asp Asn Phe His Ile Leu Ser Leu Glu Trp Lys Leu 
    50                  55                  60          


<210>  9389
<211>  1504
<212>  DNA
<213>  Homosapiens

<400>  9389
ctcatcttta tattcacgaa aaagcaatct gaagaaaaca aataaaagcc tgtgtattta     60

gcactgttag tgtcaccttt tcaacttctg aaacactgtt cattgttaac tttttctcat    120

ttataaatca ctgtatttat tttagtagta tgcatagcat atctgtgctc ttgaattaat    180

ttttatcttt aacatatttg tctcatcaat ctttaataca ctgtgtctaa tttgctacca    240

aatgtaatta tcagggtatt tataaaacca tagctaacaa aactgagcta caaaatgaaa    300

atttactaaa tagtttttaa aatcatggac ttcagcctgg cgcggtggct catgcctgta    360

atcccagcac tgtgggaggc tgaggcgggc agatcgccta agttcacgag tttgagacca    420

gcctgcagca tgacgaaacc taaaataaca aaaattagcc aggcgtggta gagtgcacct    480

gtaatccctg ctactcagga ggcggaggca ggagaatcgc ttcaacccgg gaggcggagg    540

ttgctgtgag catgccactg cactcctgcc taggcaacag agtgagaccc tgtctcaaaa    600

aaataaataa aaccatgggc ttccatgcta tcttgacaaa tttgcactct atagcatcac    660

tcaaaatact gcctattggc tttaaactcc atctgaatac tgataacttt cacattcttt    720

cactagagtg gaagctctga gactaggaat tttgttgtct ttaccccagt cctttgaata    780

gtgactacat gtaagatagt catgtagtat ttattggaaa taaatattta ttggaaaaac    840

gaaaacagat aattcctctt ctggtgttta acaggctttg aaaccaagtg ttcaggtgaa    900

agccttttta tattgattta tcagcattta ttcaaccccg tttgtcggga aatgggatta    960

cacgtgtgag ccacaatgcc cagcctgtaa atttttacac attttaaatt ctgacaaagt   1020

gagggatatg tataatgtat acatatatac aaagtgaggt aaatgtataa tgacatttgc   1080

attatacaga tacatgcaag ggttcagtaa agtttggcag cttcctagat tgtattgcca   1140

gtgaatggca gaggcattat taaacctcca ccttacccta tagcggggag accatggcag   1200

agtctcagta ggtggttgat tgttgttact gatggctctt cctgagcatg tgaaccatgg   1260

tcctcttctg cctcctagca ctgctgctgc aggacttgtt cctcgggtct tatcccagag   1320

ttctggctgc atttgacatt caggtattct tctttgcact tcagatagaa tgtaaaacac   1380

aggttcttga gtactttatg cttaactctt gtctttgcta ctcaatagct tatgatcttg   1440

agtgaattat gccattttat cccacttcac tcacctgtaa aacggggatt aaatttttac   1500

ctcc                                                                1504


<210>  9390
<211>  62
<212>  PRT
<213>  Homosapiens

<400>  9390

Met Pro Leu His Ser Cys Leu Gly Asn Arg Val Arg Pro Cys Leu Lys 
1               5                   10                  15      


Lys Ile Asn Lys Thr Met Gly Phe His Ala Ile Leu Thr Asn Leu His 
            20                  25                  30          


Ser Ile Ala Ser Leu Lys Ile Leu Pro Ile Gly Phe Lys Leu His Leu 
        35                  40                  45              


Asn Thr Asp Asn Phe His Ile Leu Ser Leu Glu Trp Lys Leu 
    50                  55                  60          


<210>  9391
<211>  1273
<212>  DNA
<213>  Homosapiens

<400>  9391
tccgaagcgg ggaagtggga caagatggtt tacatctcga acggccacca ggaaaccctc     60

cccgaagaat gggtagaatc aatcatctgc gtggccctag tccccctcca atggctggtg    120

gatgaggaag gtaaatgtct gctctaagaa gcagacaacc ggacatgcgc attcatagca    180

gaaggaaacc atcaagaagt ggaaggctga ccatgatgag cagtagatga atgtgtatgt    240

ctaaacaagg actgctctgt gtcctcacag atgaatgagg tcatgctggg aattccctct    300

gcagggaact ggcctgactg acatgcagtt ccataaatgc agatgtttgt ctcattacct    360

ttttgtatag tttattaaag tattaatata gttttaataa gtaaatattt ttaggttgca    420

gaatggactc ctcatcttta tattcacgaa aaagcaatct gaagaaaaca aataaaagcc    480

tgtgtattta gcactgttag tgtcaccttt tcaacttctg aaacactgtt cattgttaac    540

tttttctcat ttataaatca ctgtatttat tttagtagta tgcatagcat atctgtgctc    600

ttgaattaat ttttatcttt aacatatttg tctcatcaat ctttaataca ctgtgtctaa    660

tttgctacca aatgtaatta tcagggtatt tataaaacca tagctaacaa aactgagcta    720

caaaatgaaa atttactaaa tagtttttaa aatcatggac ttcagcctgg cgcggtggct    780

catgcctgta atcccagcac tgtgggaggc tgaggcgggc agatcgccta agttcacgag    840

tttgagacca gcctgcagca tgacgaaacc taaaataaca aaaattagcc aggcgtggta    900

gagtgcacct gtaatccctg ctactcagga ggcggaggca ggagaatcgc ttcaacccgg    960

gaggcggagg ttgctgtgag catgccactg cactcctgcc taggcaacag agtgagaccc   1020

tgtctcaaaa aaataaataa aaccatgggc ttccatgcta tcttgacaaa tttgcactct   1080

atagcatcac tcaaaatact gcctattggc tttaaactcc atctgaatac tgataacttt   1140

cacattcttt cactagagtg gaagctctga gactaggaat tttgttgtct ttaccccagt   1200

cctttgaata gtgactacat gtaagatagt catgtagtat ttattggaaa taaatattta   1260

ttggaaaaac gaa                                                      1273


<210>  9392
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  9392

Met Val Tyr Ile Ser Asn Gly His Gln Glu Thr Leu Pro Glu Glu Trp 
1               5                   10                  15      


Val Glu Ser Ile Ile Cys Val Ala Leu Val Pro Leu Gln Trp Leu Val 
            20                  25                  30          


Asp Glu Glu Gly Lys Cys Leu Leu 
        35                  40  


<210>  9393
<211>  1438
<212>  DNA
<213>  Homosapiens

<400>  9393
gggagcagag ggagatacag aaaccgacag gggccaggcg cccggtggct ccgaagcggg     60

gaagtgggac aagatggttt acatctcgaa cggacaagtg ttggacagcc ggagtcagtc    120

tccatggaga ttatctttga taacagattt cttctgggga atagctgagt ttgtggtttt    180

gtttttcaaa actctgcttc agcaagatgc caccaggaaa ccctccccga agaatgggta    240

gaatcaatca tctgcgtggc cctagtcccc ctccaatggc tggtggatga ggaaggtaaa    300

tgtctgctct aagaagcaga caaccggaca tgcgcattca tagcagaagg aaaccatcaa    360

gaagtggaag gctgaccatg atgagcagta gatgaatgtg tatgtctaaa caaggactgc    420

tctgtgtcct cacagatgaa tgaggtcatg ctgggaattc cctctgcagg gaactggcct    480

gactgacatg cagttccata aatgcagatg tttgtctcat tacctttttg tatagtttat    540

taaagtatta atatagtttt aataagtaaa tatttttagg ttgcagaatg gactcctcat    600

ctttatattc acgaaaaagc aatctgaaga aaacaaataa aagcctgtgt atttagcact    660

gttagtgtca ccttttcaac ttctgaaaca ctgttcattg ttaacttttt ctcatttata    720

aatcactgta tttattttag tagtatgcat agcatatctg tgctcttgaa ttaattttta    780

tctttaacat atttgtctca tcaatcttta atacactgtg tctaatttgc taccaaatgt    840

aattatcagg gtatttataa aaccatagct aacaaaactg agctacaaaa tgaaaattta    900

ctaaatagtt tttaaaatca tggacttcag cctggcgcgg tggctcatgc ctgtaatccc    960

agcactgtgg gaggctgagg cgggcagatc gcctaagttc acgagtttga gaccagcctg   1020

cagcatgacg aaacctaaaa taacaaaaat tagccaggcg tggtagagtg cacctgtaat   1080

ccctgctact caggaggcgg aggcaggaga atcgcttcaa cccgggaggc ggaggttgct   1140

gtgagcatgc cactgcactc ctgcctaggc aacagagtga gaccctgtct caaaaaaata   1200

aataaaacca tgggcttcca tgctatcttg acaaatttgc actctatagc atcactcaaa   1260

atactgccta ttggctttaa actccatctg aatactgata actttcacat tctttcacta   1320

gagtggaagc tctgagacta ggaattttgt tgtctttacc ccagtccttt gaatagtgac   1380

tacatgtaag atagtcatgt agtatttatt ggaaataaat atttattgga aaaacgaa     1438


<210>  9394
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  9394

Met Val Tyr Ile Ser Asn Gly Gln Val Leu Asp Ser Arg Ser Gln Ser 
1               5                   10                  15      


Pro Trp Arg Leu Ser Leu Ile Thr Asp Phe Phe Trp Gly Ile Ala Glu 
            20                  25                  30          


Phe Val Val Leu Phe Phe Lys Thr Leu Leu Gln Gln Asp Ala Thr Arg 
        35                  40                  45              


Lys Pro Ser Pro Lys Asn Gly 
    50                  55  


<210>  9395
<211>  1624
<212>  DNA
<213>  Homosapiens

<400>  9395
aagtcgcaga tgtgacgatg caaaaacgcc cgtcgggggc gcgtctcttt cagcagccaa     60

tgggctctgc ccaccttcgt cctcgtcagc attttgtcta atcgcggcct gtgacgctcg    120

aagggcgggg agcagaggga gatacagaaa ccgacagggg ccaggcgccc ggtggctccg    180

aagcggggaa gtgggacaag atggtttaca tctcgaacgg acaagtgttg gacagccgga    240

gtcagtctcc atggagatta tctttgataa cagatttctt ctggggaata gctgagtttg    300

tggttttgtt tttcaaaact ctgcttcagc aagatgtgaa aaaaagaaga agctatggaa    360

actcatctga ttccagatat gatgatggaa gagggccacc aggaaaccct ccccgaagaa    420

tgggtagaat caatcatctg cgtggcccta gtccccctcc aatggctggt ggatgaggaa    480

ggtaaatgtc tgctctaaga agcagacaac cggacatgcg cattcatagc agaaggaaac    540

catcaagaag tggaaggctg accatgatga gcagtagatg aatgtgtatg tctaaacaag    600

gactgctctg tgtcctcaca gatgaatgag gtcatgctgg gaattccctc tgcagggaac    660

tggcctgact gacatgcagt tccataaatg cagatgtttg tctcattacc tttttgtata    720

gtttattaaa gtattaatat agttttaata agtaaatatt tttaggttgc agaatggact    780

cctcatcttt atattcacga aaaagcaatc tgaagaaaac aaataaaagc ctgtgtattt    840

agcactgtta gtgtcacctt ttcaacttct gaaacactgt tcattgttaa ctttttctca    900

tttataaatc actgtattta ttttagtagt atgcatagca tatctgtgct cttgaattaa    960

tttttatctt taacatattt gtctcatcaa tctttaatac actgtgtcta atttgctacc   1020

aaatgtaatt atcagggtat ttataaaacc atagctaaca aaactgagct acaaaatgaa   1080

aatttactaa atagttttta aaatcatgga cttcagcctg gcgcggtggc tcatgcctgt   1140

aatcccagca ctgtgggagg ctgaggcggg cagatcgcct aagttcacga gtttgagacc   1200

agcctgcagc atgacgaaac ctaaaataac aaaaattagc caggcgtggt agagtgcacc   1260

tgtaatccct gctactcagg aggcggaggc aggagaatcg cttcaacccg ggaggcggag   1320

gttgctgtga gcatgccact gcactcctgc ctaggcaaca gagtgagacc ctgtctcaaa   1380

aaaataaata aaaccatggg cttccatgct atcttgacaa atttgcactc tatagcatca   1440

ctcaaaatac tgcctattgg ctttaaactc catctgaata ctgataactt tcacattctt   1500

tcactagagt ggaagctctg agactaggaa ttttgttgtc tttaccccag tcctttgaat   1560

agtgactaca tgtaagatag tcatgtagta tttattggaa ataaatattt attggaaaaa   1620

cgaa                                                                1624


<210>  9396
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  9396

Met Val Tyr Ile Ser Asn Gly Gln Val Leu Asp Ser Arg Ser Gln Ser 
1               5                   10                  15      


Pro Trp Arg Leu Ser Leu Ile Thr Asp Phe Phe Trp Gly Ile Ala Glu 
            20                  25                  30          


Phe Val Val Leu Phe Phe Lys Thr Leu Leu Gln Gln Asp Val Lys Lys 
        35                  40                  45              


Arg Arg Ser Tyr Gly Asn Ser Ser Asp Ser Arg Tyr Asp Asp Gly Arg 
    50                  55                  60                  


Gly Pro Pro Gly Asn Pro Pro Arg Arg Met Gly Arg Ile Asn His Leu 
65                  70                  75                  80  


Arg Gly Pro Ser Pro Pro Pro Met Ala Gly Gly 
                85                  90      


<210>  9397
<211>  849
<212>  DNA
<213>  Homosapiens

<400>  9397
aagtcgcaga tgtgacgatg caaaaacgcc cgtcgggggc gcgtctcttt cagcagccaa     60

tgggctctgc ccaccttcgt cctcgtcagc attttgtcta atcgcggcct gtgacgctcg    120

aagggcgggg agcagaggga gatacagaaa ccgacagggg ccaggcgccc ggtggctccg    180

aagcggggaa gtgggacaag atggtttaca tctcgaacgg acaagtgttg gacagccgga    240

gtcagtctcc atggagatta tctttgataa cagatttctt ctggggaata gctgagtttg    300

tggttttgtt tttcaaaact ctgcttcagc aagatgtgaa aaaaagaaga agctatggaa    360

actcatctga ttccagatat gatgatggaa gagggccacc aggaaaccct ccccgaagaa    420

tgggtagaat caatcatctg cgtggcccta gtccccctcc aatggctggt ggatgaggaa    480

ggtaaatgtc tgctctaaga agcagacaac cggacatgcg cattcatagc agaaggaaac    540

catcaagaag tggaaggctg accatgatga gcagtagatg aatgtgtatg tctaaacaag    600

gactgctctg tgtcctcaca gatgaatgag gtcatgctgg gaattccctc tgcagggaac    660

tggcctgact gacatgcagt tccataaatg cagatgtttg tctcattacc tttttgtata    720

gtttattaaa gtattaatat agttttaata agtaaatatt tttaggttgc agaatggact    780

cctcatcttt atattcacga aaaagcaatc tgaagaaaac aaataaaagc ctgtgtattt    840

agcactgtt                                                            849


<210>  9398
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  9398

Met Val Tyr Ile Ser Asn Gly Gln Val Leu Asp Ser Arg Ser Gln Ser 
1               5                   10                  15      


Pro Trp Arg Leu Ser Leu Ile Thr Asp Phe Phe Trp Gly Ile Ala Glu 
            20                  25                  30          


Phe Val Val Leu Phe Phe Lys Thr Leu Leu Gln Gln Asp Val Lys Lys 
        35                  40                  45              


Arg Arg Ser Tyr Gly Asn Ser Ser Asp Ser Arg Tyr Asp Asp Gly Arg 
    50                  55                  60                  


Gly Pro Pro Gly Asn Pro Pro Arg Arg Met Gly Arg Ile Asn His Leu 
65                  70                  75                  80  


Arg Gly Pro Ser Pro Pro Pro Met Ala Gly Gly 
                85                  90      


<210>  9399
<211>  496
<212>  DNA
<213>  Homosapiens

<400>  9399
tccgaagcgg ggaagtggga caagatggtt tacatctcga acggccacca ggaaaccctc     60

cccgaagaat gggtagaatc aatcatctgc gtggccctag tccccctcca atggctggtg    120

gatgaggaag gtaaatgtct gctctaagaa gcagacaacc ggacatgcgc attcatagca    180

gaaggaaacc atcaagaagt ggaaggctga ccatgatgag cagtagatga atgtgtatgt    240

ctaaacaagg actgctctgt gtcctcacag atgaatgagg tcatgctggg aattccctct    300

gcagggaact ggcctgactg acatgcagtt ccataaatgc agatgtttgt ctcattacct    360

ttttgtatag tttattaaag tattaatata gttttaataa gtaaatattt ttaggttgca    420

gaatggactc ctcatcttta tattcacgaa aaagcaatct gaagaaaaca aataaaagcc    480

tgtgtattta gcactg                                                    496


<210>  9400
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  9400

Met Val Tyr Ile Ser Asn Gly His Gln Glu Thr Leu Pro Glu Glu Trp 
1               5                   10                  15      


Val Glu Ser Ile Ile Cys Val Ala Leu Val Pro Leu Gln Trp Leu Val 
            20                  25                  30          


Asp Glu Glu Gly Lys Cys Leu Leu 
        35                  40  


<210>  9401
<211>  661
<212>  DNA
<213>  Homosapiens

<400>  9401
gggagcagag ggagatacag aaaccgacag gggccaggcg cccggtggct ccgaagcggg     60

gaagtgggac aagatggttt acatctcgaa cggacaagtg ttggacagcc ggagtcagtc    120

tccatggaga ttatctttga taacagattt cttctgggga atagctgagt ttgtggtttt    180

gtttttcaaa actctgcttc agcaagatgc caccaggaaa ccctccccga agaatgggta    240

gaatcaatca tctgcgtggc cctagtcccc ctccaatggc tggtggatga ggaaggtaaa    300

tgtctgctct aagaagcaga caaccggaca tgcgcattca tagcagaagg aaaccatcaa    360

gaagtggaag gctgaccatg atgagcagta gatgaatgtg tatgtctaaa caaggactgc    420

tctgtgtcct cacagatgaa tgaggtcatg ctgggaattc cctctgcagg gaactggcct    480

gactgacatg cagttccata aatgcagatg tttgtctcat tacctttttg tatagtttat    540

taaagtatta atatagtttt aataagtaaa tatttttagg ttgcagaatg gactcctcat    600

ctttatattc acgaaaaagc aatctgaaga aaacaaataa aagcctgtgt atttagcact    660

g                                                                    661


<210>  9402
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  9402

Met Val Tyr Ile Ser Asn Gly Gln Val Leu Asp Ser Arg Ser Gln Ser 
1               5                   10                  15      


Pro Trp Arg Leu Ser Leu Ile Thr Asp Phe Phe Trp Gly Ile Ala Glu 
            20                  25                  30          


Phe Val Val Leu Phe Phe Lys Thr Leu Leu Gln Gln Asp Ala Thr Arg 
        35                  40                  45              


Lys Pro Ser Pro Lys Asn Gly 
    50                  55  


<210>  9403
<211>  584
<212>  DNA
<213>  Homosapiens

<400>  9403
gggagcagag ggagatacag aaaccgacag gggccaggcg cccggtggct ccgaagcggg     60

gaagtgggac aagatggttt acatctcgaa cggacaagtg ttggacagcc ggagtcagtc    120

tccatggaga ttatctttga taacagattt cttctgggga atagctgagt ttgtggtttt    180

gtttttcaaa actctgcttc agcaagatgc caccaggaaa ccctccccga agaatgggta    240

gaatcaatca tctgcgtggc cctagtcccc ctccaatggc tggtggatga ggaaggtaaa    300

tgtctgctct aagaagcaga caaccggaca tgcgcattca tagcagaagg aaaccatcaa    360

gaagtggaag gctgaccatg atgagcagta gatgaatgtg tatgtctaaa caaggactgc    420

tctgtgtcct cacagatgaa tgaggtcatg ctgggaattc cctctgcagg gaactggcct    480

gactgacatg cagttccata aatgcagatg tttgtctcat tacctttttg tatagtttat    540

taaagtatta atatagtttt aataagtaaa tatttttagg ttgc                     584


<210>  9404
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  9404

Met Val Tyr Ile Ser Asn Gly Gln Val Leu Asp Ser Arg Ser Gln Ser 
1               5                   10                  15      


Pro Trp Arg Leu Ser Leu Ile Thr Asp Phe Phe Trp Gly Ile Ala Glu 
            20                  25                  30          


Phe Val Val Leu Phe Phe Lys Thr Leu Leu Gln Gln Asp Ala Thr Arg 
        35                  40                  45              


Lys Pro Ser Pro Lys Asn Gly 
    50                  55  


<210>  9405
<211>  770
<212>  DNA
<213>  Homosapiens

<400>  9405
aagtcgcaga tgtgacgatg caaaaacgcc cgtcgggggc gcgtctcttt cagcagccaa     60

tgggctctgc ccaccttcgt cctcgtcagc attttgtcta atcgcggcct gtgacgctcg    120

aagggcgggg agcagaggga gatacagaaa ccgacagggg ccaggcgccc ggtggctccg    180

aagcggggaa gtgggacaag atggtttaca tctcgaacgg acaagtgttg gacagccgga    240

gtcagtctcc atggagatta tctttgataa cagatttctt ctggggaata gctgagtttg    300

tggttttgtt tttcaaaact ctgcttcagc aagatgtgaa aaaaagaaga agctatggaa    360

actcatctga ttccagatat gatgatggaa gagggccacc aggaaaccct ccccgaagaa    420

tgggtagaat caatcatctg cgtggcccta gtccccctcc aatggctggt ggatgaggaa    480

ggtaaatgtc tgctctaaga agcagacaac cggacatgcg cattcatagc agaaggaaac    540

catcaagaag tggaaggctg accatgatga gcagtagatg aatgtgtatg tctaaacaag    600

gactgctctg tgtcctcaca gatgaatgag gtcatgctgg gaattccctc tgcagggaac    660

tggcctgact gacatgcagt tccataaatg cagatgtttg tctcattacc tttttgtata    720

gtttattaaa gtattaatat agttttaata agtaaatatt tttaggttgc               770


<210>  9406
<211>  91
<212>  PRT
<213>  Homosapiens

<400>  9406

Met Val Tyr Ile Ser Asn Gly Gln Val Leu Asp Ser Arg Ser Gln Ser 
1               5                   10                  15      


Pro Trp Arg Leu Ser Leu Ile Thr Asp Phe Phe Trp Gly Ile Ala Glu 
            20                  25                  30          


Phe Val Val Leu Phe Phe Lys Thr Leu Leu Gln Gln Asp Val Lys Lys 
        35                  40                  45              


Arg Arg Ser Tyr Gly Asn Ser Ser Asp Ser Arg Tyr Asp Asp Gly Arg 
    50                  55                  60                  


Gly Pro Pro Gly Asn Pro Pro Arg Arg Met Gly Arg Ile Asn His Leu 
65                  70                  75                  80  


Arg Gly Pro Ser Pro Pro Pro Met Ala Gly Gly 
                85                  90      


<210>  9407
<211>  594
<212>  DNA
<213>  Homosapiens

<400>  9407
agatggaaat gcagaaatca cccgtcttct ccgtcgctca cgctgggagc tgtagactgg     60

agctgttcct attcggccat cttggctcct ccctccatcg gtaaaccaac tctttaacaa    120

aggggagctg aggctctgtg gctggaacct gggacttagg cctgaattaa tcagagcaat    180

gcactccact ggccatggag gtggaagttg tattcacaag ctctaaatgt cagccttcat    240

ctttagacct agtggaaagc aaagaagaca aaacgtgatg caatgaacct tgttatggta    300

cccaaaatat ggggatctag cttctgttag catgcctgca tccctgtctt ggccccactg    360

atgaggagca ggcaagatag ggattctgag tatgaaggaa gttactgaag caattaacaa    420

tcagagtgtc tgattagtgc tataatttca aatgtaaaca acaacaaaaa accttttaga    480

tttcaggtga gaattgcact cttcaaagat ggttcctctc tgtggctgta gttagtgtag    540

tgaattggat attcttggat tgagtcaatt ttatatctca agtatatttt tctt          594


<210>  9408
<211>  33
<212>  PRT
<213>  Homosapiens

<400>  9408

Met Glu Met Gln Lys Ser Pro Val Phe Ser Val Ala His Ala Gly Ser 
1               5                   10                  15      


Cys Arg Leu Glu Leu Phe Leu Phe Gly His Leu Gly Ser Ser Leu His 
            20                  25                  30          


Arg 
    


<210>  9409
<211>  836
<212>  DNA
<213>  Homosapiens

<400>  9409
gctcttagaa gaccagccac ttttgtccct gcagcccggg gccacagagc cagacaccag     60

acccacagca gcccgggaag taacggtcgc tctgtctcgt ctgggaagat ctccgttgcc    120

agggcttgct ggacccgccc ccgcacagct tcccagcagt cccgattccg cctgaggctc    180

cagaaggcga agctgtacag gaggccactt ttcttctcag cctagaactc gagagacctg    240

aaaggaagga cgactggcca caggagatgt ttcacagagc cgctgaatga acaacacagt    300

caattctgat caactttcca gtgctatctg ggtgtaagtg agtggccctg gaggtgggtg    360

cctctccccg gcgcagtttt tccttccatc acaagcatgg ctgaagctgg gtggtggtgc    420

atacagattc cagccagcaa ggaggggaaa gagagttcag aggactcacc tccactgtcc    480

ccgacccagg cctgtagcat ctatattggc tcctctcagg ttccacagcc aaaagcctag    540

tcccaaggga gtgctacaga gaagaaaaaa tcatcacaaa acagggcatt aaaactctgg    600

ggacacgaat ctgaaaccac cacatcaccc ctccttaatt tcagagtctc cctccccagc    660

caggcttgga gggaaatgtg gaacatcact ctgggaatcc cttccggaca ccattatgtt    720

ctagttactg cctacgagga cctacttggt atttctcatc ttaccctgat tgcattcaaa    780

acttgattag attctattga tcctgtcata aaaaaataaa gctggtctgc ttttcc        836


<210>  9410
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  9410

Met Ala Glu Ala Gly Trp Trp Cys Ile Gln Ile Pro Ala Ser Lys Glu 
1               5                   10                  15      


Gly Lys Glu Ser Ser Glu Asp Ser Pro Pro Leu Ser Pro Thr Gln Ala 
            20                  25                  30          


Cys Ser Ile Tyr Ile Gly Ser Ser Gln Val Pro Gln Pro Lys Ala 
        35                  40                  45          


<210>  9411
<211>  396
<212>  DNA
<213>  Homosapiens

<400>  9411
caggagatgt ttcacagagc cgctgaatga acaacacagt caattctgat caactttcca     60

gtgctatctg gggggatttg taaactcggc gaggagagca tttgtaaaag ggttaagtac    120

cccagttttc taactgaatt actacaccat taaaatgagc tccgcacaac atggcagcaa    180

ataggcttct gtctgagaga cagagaaggg tgtatatggc ttctttacca aatcggagag    240

ctgaaaaccc aagcagagtc acgtcctagg agtaggcact gaccgccaca gtcacctgcc    300

cgtcctgtca agcaactttt cccagctaac ctgagttccc atcctaattc tttaaagcac    360

tgaaaagttt ttgaaaagaa agacacaaga aatatt                              396


<210>  9412
<211>  32
<212>  PRT
<213>  Homosapiens

<400>  9412

Met Ala Ala Asn Arg Leu Leu Ser Glu Arg Gln Arg Arg Val Tyr Met 
1               5                   10                  15      


Ala Ser Leu Pro Asn Arg Arg Ala Glu Asn Pro Ser Arg Val Thr Ser 
            20                  25                  30          


<210>  9413
<211>  3603
<212>  DNA
<213>  Homosapiens

<400>  9413
cggccgctct cgtcgccgcc gcagcgggcg cgtcggaggg agcccagcat ggccgggccg     60

ggctcgccgc gccgcgcgtc ccggggggcc tcggcgcttc tcgctgccgc gcttctctac    120

gccgcgctgg gggacgtggt gcgctcggag cagcagatac cgctctccgt ggtgaagctc    180

tgggcctcgg cttttggtgg ggagataaaa tccattgctg ctaagtactc cggttcccag    240

cttctgcaaa agaaatacaa agagtatgag aaagacgttg ccatagaaga aattgatggc    300

ctccaactgg taaagaagct ggcaaagaac atggaagaga tgtttcacaa gaagtctgag    360

gccgtcaggc agtatgaata cttcaatgct gtgctgataa atgaaaggga caaagacggg    420

aattttttgg agctgggaaa ggaattcatc ttagccccaa atgaccattt taataatttg    480

cctgtgaaca tcagtctaag tgacgtccaa gtaccaacga acatgtacaa caaagaccct    540

gcaattgtca atggggttta ttggtctgaa tctctaaaca aagtttttgt agataacttt    600

gaccgtgacc catctctcat atggcagtac tttggaagtg caaagggctt ttttaggcag    660

tatccgggga ttaaatggga accagatgag aatggagtca ttgccttcga ctgcaggaac    720

cgaaaatggt acatccaggc agcaacttct ccgaaagacg tggtcatttt agttgacgtc    780

agtggcagca tgaaaggact ccgtctgact atcgcgaagc aaacagtctc atccattttg    840

gatacacttg gggatgatga cttcttcaac ataattgctt ataatgagga gcttcactat    900

gtggaacctt gcctgaatgg aactttggtg caagccgaca ggacaaacaa agagcacttc    960

agggagcatc tggacaaact tttcgccaaa ggaattggaa tgttggatat agctctgaat   1020

gaggccttca acattctgag tgatttcaac cacacgggac aaggaagtat ctgcagtcag   1080

gccatcatgc tcataactga tggggcggtg gacacctatg atacaatctt tgcaaaatac   1140

aattggccag atcgaaaggt tcgcatcttc acatacctca ttggacgaga ggctgcgttt   1200

gcagacaatc taaagtggat ggcctgtgcc aacaaaggat tttttaccca gatctccacc   1260

ttggctgatg tgcaggagaa tgtcatggaa taccttcacg tgcttagccg gcccaaagtc   1320

atcgaccagg agcatgatgt ggtgtggacc gaagcttaca ttgacagcac tctgactgat   1380

gatcagggcc ccgtcctgat gaccactgta gccatgcctg tgtttagtaa gcagaacgaa   1440

accagatcga agggcattct tctgggagtg gttggcacag atgtcccagt gaaagaactt   1500

ctgaagacca tccccaaata caagttaggg attcacggtt atgcctttgc aatcacaaat   1560

aatggatata tcctgacgca tccggaactc aggctgctgt acgaagaagg aaaaaagcga   1620

aggaaaccta actatagtag cgttgacctc tctgaggtgg agtgggaaga ccgagatgac   1680

gtgttgagaa atgctatggt gaatcgaaag acggggaagt tttccatgga ggtgaagaag   1740

acagtggaca aagggaaacg ggttttggtg atgacaaatg actactatta tacagacatc   1800

aagggtactc ctttcagttt aggtgtggcg ctttccagag gtcatgggaa atatttcttc   1860

cgagggaatg taaccatcga agaaggcctg catgacttag aacatcccga tgtgtccttg   1920

gcagatgaat ggtcctactg caacactgac ctacaccctg agcaccgcca tctgtctcag   1980

ttagaagcga ttaagctcta cctaaaaggc aaagaacctc tgctccagtg tgataaagaa   2040

ttgatccaag aagtcctttt tgacgcggtg gtgagtgccc ccattgaagc gtattggacc   2100

agcctggccc tcaacaaatc tgaaaattct gacaagggcg tggaggttgc cttcctcggc   2160

actcgcacgg gcctctccag aatcaacctg tttgtcgggg ctgagcagct caccaatcag   2220

gacttcctga aagctggcga caaggagaac atttttaacg cagaccattt ccctctctgg   2280

taccgaagag ccgctgagca gattccaggg agcttcgtct actcgatccc attcagcact   2340

ggaccagtca ataaaagcaa tgtggtgaca gcaagtacat ccatccagct cctggatgaa   2400

cggaaatctc ctgtggtggc agctgtaggc attcagatga aacttgaatt tttccaaagg   2460

aagttctgga ctgccagcag acagtgtgct tccctggatg gcaaatgctc catcagctgt   2520

gatgatgaga ctgtgaattg ttacctcata gacaataatg gatttatttt ggtgtctgaa   2580

gactacacac agactggaga cttttttggt gagatcgagg gagctgtgat gaacaaattg   2640

ctaacaatgg gctcctttaa aagaattacc ctttatgact accaagccat gtgtagagcc   2700

aacaaggaaa gcagcgatgg cgcccatggc ctcctggatc cttataatgc cttcctctct   2760

gcagtaaaat ggatcatgac agaacttgtc ttgttcctgg tggaatttaa cctctgcagt   2820

tggtggcact ccgatatgac agctaaagcc cagaaattga aacagaccct ggagccttgt   2880

gatactgaat atccagcatt cgtctctgag cgcaccatca aggagactac agggaatatt   2940

gcttgtgaag actgctccaa gtcctttgtc atccagcaaa tcccaagcag caacctgttc   3000

atggtggtgg tggacagcag ctgcctctgt gaatctgtgg cccccatcac catggcaccc   3060

attgaaatca gtcaacataa tgaatccctt aagtgtgaac gtctaaaggc ccagaagatc   3120

agaaggcgcc cagaatcttg tcatggcttc catcctgagg agaatgcaag ggagtgtggg   3180

ggtgcgccga gtctccaagc ccagacagtc ctccttctgc tccctctgct tttgatgctc   3240

ttctcaaggt gacactgact gagatgttct cttactgact gagatgttct cttggcatgc   3300

taaatcatgg ataaactgtg aaccaaaata tggtgcaaca tacgagacat gaatatagtc   3360

caaccatcag catctcatca tgattttaaa ctgtgcgtga tataaactct taaagatatg   3420

ttgacaaaaa gttatctatc atctttttac tttgccagtc atgcaaatgt gagtttgcca   3480

catgataatc acccttcatc agaaatggga ccgcaagtgg taggcagtgt cccttctgct   3540

tgaaacctat tgaaaccaat ttaaaactgt gtacttttta aataaagtat attaaaatca   3600

taa                                                                 3603


<210>  9414
<211>  1067
<212>  PRT
<213>  Homosapiens

<400>  9414

Met Ala Gly Pro Gly Ser Pro Arg Arg Ala Ser Arg Gly Ala Ser Ala 
1               5                   10                  15      


Leu Leu Ala Ala Ala Leu Leu Tyr Ala Ala Leu Gly Asp Val Val Arg 
            20                  25                  30          


Ser Glu Gln Gln Ile Pro Leu Ser Val Val Lys Leu Trp Ala Ser Ala 
        35                  40                  45              


Phe Gly Gly Glu Ile Lys Ser Ile Ala Ala Lys Tyr Ser Gly Ser Gln 
    50                  55                  60                  


Leu Leu Gln Lys Lys Tyr Lys Glu Tyr Glu Lys Asp Val Ala Ile Glu 
65                  70                  75                  80  


Glu Ile Asp Gly Leu Gln Leu Val Lys Lys Leu Ala Lys Asn Met Glu 
                85                  90                  95      


Glu Met Phe His Lys Lys Ser Glu Ala Val Arg Gln Tyr Glu Tyr Phe 
            100                 105                 110         


Asn Ala Val Leu Ile Asn Glu Arg Asp Lys Asp Gly Asn Phe Leu Glu 
        115                 120                 125             


Leu Gly Lys Glu Phe Ile Leu Ala Pro Asn Asp His Phe Asn Asn Leu 
    130                 135                 140                 


Pro Val Asn Ile Ser Leu Ser Asp Val Gln Val Pro Thr Asn Met Tyr 
145                 150                 155                 160 


Asn Lys Asp Pro Ala Ile Val Asn Gly Val Tyr Trp Ser Glu Ser Leu 
                165                 170                 175     


Asn Lys Val Phe Val Asp Asn Phe Asp Arg Asp Pro Ser Leu Ile Trp 
            180                 185                 190         


Gln Tyr Phe Gly Ser Ala Lys Gly Phe Phe Arg Gln Tyr Pro Gly Ile 
        195                 200                 205             


Lys Trp Glu Pro Asp Glu Asn Gly Val Ile Ala Phe Asp Cys Arg Asn 
    210                 215                 220                 


Arg Lys Trp Tyr Ile Gln Ala Ala Thr Ser Pro Lys Asp Val Val Ile 
225                 230                 235                 240 


Leu Val Asp Val Ser Gly Ser Met Lys Gly Leu Arg Leu Thr Ile Ala 
                245                 250                 255     


Lys Gln Thr Val Ser Ser Ile Leu Asp Thr Leu Gly Asp Asp Asp Phe 
            260                 265                 270         


Phe Asn Ile Ile Ala Tyr Asn Glu Glu Leu His Tyr Val Glu Pro Cys 
        275                 280                 285             


Leu Asn Gly Thr Leu Val Gln Ala Asp Arg Thr Asn Lys Glu His Phe 
    290                 295                 300                 


Arg Glu His Leu Asp Lys Leu Phe Ala Lys Gly Ile Gly Met Leu Asp 
305                 310                 315                 320 


Ile Ala Leu Asn Glu Ala Phe Asn Ile Leu Ser Asp Phe Asn His Thr 
                325                 330                 335     


Gly Gln Gly Ser Ile Cys Ser Gln Ala Ile Met Leu Ile Thr Asp Gly 
            340                 345                 350         


Ala Val Asp Thr Tyr Asp Thr Ile Phe Ala Lys Tyr Asn Trp Pro Asp 
        355                 360                 365             


Arg Lys Val Arg Ile Phe Thr Tyr Leu Ile Gly Arg Glu Ala Ala Phe 
    370                 375                 380                 


Ala Asp Asn Leu Lys Trp Met Ala Cys Ala Asn Lys Gly Phe Phe Thr 
385                 390                 395                 400 


Gln Ile Ser Thr Leu Ala Asp Val Gln Glu Asn Val Met Glu Tyr Leu 
                405                 410                 415     


His Val Leu Ser Arg Pro Lys Val Ile Asp Gln Glu His Asp Val Val 
            420                 425                 430         


Trp Thr Glu Ala Tyr Ile Asp Ser Thr Leu Thr Asp Asp Gln Gly Pro 
        435                 440                 445             


Val Leu Met Thr Thr Val Ala Met Pro Val Phe Ser Lys Gln Asn Glu 
    450                 455                 460                 


Thr Arg Ser Lys Gly Ile Leu Leu Gly Val Val Gly Thr Asp Val Pro 
465                 470                 475                 480 


Val Lys Glu Leu Leu Lys Thr Ile Pro Lys Tyr Lys Leu Gly Ile His 
                485                 490                 495     


Gly Tyr Ala Phe Ala Ile Thr Asn Asn Gly Tyr Ile Leu Thr His Pro 
            500                 505                 510         


Glu Leu Arg Leu Leu Tyr Glu Glu Gly Lys Lys Arg Arg Lys Pro Asn 
        515                 520                 525             


Tyr Ser Ser Val Asp Leu Ser Glu Val Glu Trp Glu Asp Arg Asp Asp 
    530                 535                 540                 


Val Leu Arg Asn Ala Met Val Asn Arg Lys Thr Gly Lys Phe Ser Met 
545                 550                 555                 560 


Glu Val Lys Lys Thr Val Asp Lys Gly Lys Arg Val Leu Val Met Thr 
                565                 570                 575     


Asn Asp Tyr Tyr Tyr Thr Asp Ile Lys Gly Thr Pro Phe Ser Leu Gly 
            580                 585                 590         


Val Ala Leu Ser Arg Gly His Gly Lys Tyr Phe Phe Arg Gly Asn Val 
        595                 600                 605             


Thr Ile Glu Glu Gly Leu His Asp Leu Glu His Pro Asp Val Ser Leu 
    610                 615                 620                 


Ala Asp Glu Trp Ser Tyr Cys Asn Thr Asp Leu His Pro Glu His Arg 
625                 630                 635                 640 


His Leu Ser Gln Leu Glu Ala Ile Lys Leu Tyr Leu Lys Gly Lys Glu 
                645                 650                 655     


Pro Leu Leu Gln Cys Asp Lys Glu Leu Ile Gln Glu Val Leu Phe Asp 
            660                 665                 670         


Ala Val Val Ser Ala Pro Ile Glu Ala Tyr Trp Thr Ser Leu Ala Leu 
        675                 680                 685             


Asn Lys Ser Glu Asn Ser Asp Lys Gly Val Glu Val Ala Phe Leu Gly 
    690                 695                 700                 


Thr Arg Thr Gly Leu Ser Arg Ile Asn Leu Phe Val Gly Ala Glu Gln 
705                 710                 715                 720 


Leu Thr Asn Gln Asp Phe Leu Lys Ala Gly Asp Lys Glu Asn Ile Phe 
                725                 730                 735     


Asn Ala Asp His Phe Pro Leu Trp Tyr Arg Arg Ala Ala Glu Gln Ile 
            740                 745                 750         


Pro Gly Ser Phe Val Tyr Ser Ile Pro Phe Ser Thr Gly Pro Val Asn 
        755                 760                 765             


Lys Ser Asn Val Val Thr Ala Ser Thr Ser Ile Gln Leu Leu Asp Glu 
    770                 775                 780                 


Arg Lys Ser Pro Val Val Ala Ala Val Gly Ile Gln Met Lys Leu Glu 
785                 790                 795                 800 


Phe Phe Gln Arg Lys Phe Trp Thr Ala Ser Arg Gln Cys Ala Ser Leu 
                805                 810                 815     


Asp Gly Lys Cys Ser Ile Ser Cys Asp Asp Glu Thr Val Asn Cys Tyr 
            820                 825                 830         


Leu Ile Asp Asn Asn Gly Phe Ile Leu Val Ser Glu Asp Tyr Thr Gln 
        835                 840                 845             


Thr Gly Asp Phe Phe Gly Glu Ile Glu Gly Ala Val Met Asn Lys Leu 
    850                 855                 860                 


Leu Thr Met Gly Ser Phe Lys Arg Ile Thr Leu Tyr Asp Tyr Gln Ala 
865                 870                 875                 880 


Met Cys Arg Ala Asn Lys Glu Ser Ser Asp Gly Ala His Gly Leu Leu 
                885                 890                 895     


Asp Pro Tyr Asn Ala Phe Leu Ser Ala Val Lys Trp Ile Met Thr Glu 
            900                 905                 910         


Leu Val Leu Phe Leu Val Glu Phe Asn Leu Cys Ser Trp Trp His Ser 
        915                 920                 925             


Asp Met Thr Ala Lys Ala Gln Lys Leu Lys Gln Thr Leu Glu Pro Cys 
    930                 935                 940                 


Asp Thr Glu Tyr Pro Ala Phe Val Ser Glu Arg Thr Ile Lys Glu Thr 
945                 950                 955                 960 


Thr Gly Asn Ile Ala Cys Glu Asp Cys Ser Lys Ser Phe Val Ile Gln 
                965                 970                 975     


Gln Ile Pro Ser Ser Asn Leu Phe Met Val Val Val Asp Ser Ser Cys 
            980                 985                 990         


Leu Cys Glu Ser Val Ala Pro Ile  Thr Met Ala Pro Ile  Glu Ile Ser 
        995                 1000                 1005             


Gln His  Asn Glu Ser Leu Lys  Cys Glu Arg Leu Lys  Ala Gln Lys 
    1010                 1015                 1020             


Ile Arg  Arg Arg Pro Glu Ser  Cys His Gly Phe His  Pro Glu Glu 
    1025                 1030                 1035             


Asn Ala  Arg Glu Cys Gly Gly  Ala Pro Ser Leu Gln  Ala Gln Thr 
    1040                 1045                 1050             


Val Leu  Leu Leu Leu Pro Leu  Leu Leu Met Leu Phe  Ser Arg 
    1055                 1060                 1065         


<210>  9415
<211>  3368
<212>  DNA
<213>  Homosapiens

<400>  9415
gttgactgtg acacgggtgt tacatatctt cctgtgcccc ttctccctgt agggtgaagc     60

tctgggcctc ggcttttggt ggggagataa aatccattgc tgctaagtac tccggttccc    120

agcttctgca aaagcagtat gaatacttca atgctgtgct gataaatgaa agggacaaag    180

acgggaattt tttggagctg ggaaaggaat tcatcttagc cccaaatgac cattttaata    240

atttgcctgt gaacatcagt ctaagtgacg tccaagtacc aacgaacatg tacaacaaag    300

accctgcaat tgtcaatggg gtttattggt ctgaatctct aaacaaagtt tttgtagata    360

actttgaccg tgacccatct ctcatatggc agtactttgg aagtgcaaag ggctttttta    420

ggcagtatcc ggggattaaa tgggaaccag atgagaatgg agtcattgcc ttcgactgca    480

ggaaccgaaa atggtacatc caggcagcaa cttctccgaa agacgtggtc attttagttg    540

acgtcagtgg cagcatgaaa ggactccgtc tgactatcgc gaagcaaaca gtctcatcca    600

ttttggatac acttggggat gatgacttct tcaacataat tgcttataat gaggagcttc    660

actatgtgga accttgcctg aatggaactt tggtgcaagc cgacaggaca aacaaagagc    720

acttcaggga gcatctggac aaacttttcg ccaaaggaat tggaatgttg gatatagctc    780

tgaatgaggc cttcaacatt ctgagtgatt tcaaccacac gggacaagga agtatctgca    840

gtcaggccat catgctcata actgatgggg cggtggacac ctatgataca atctttgcaa    900

aatacaattg gccagatcga aaggttcgca tcttcacata cctcattgga cgagaggctg    960

cgtttgcaga caatctaaag tggatggcct gtgccaacaa aggatttttt acccagatct   1020

ccaccttggc tgatgtgcag gagaatgtca tggaatacct tcacgtgctt agccggccca   1080

aagtcatcga ccaggagcat gatgtggtgt ggaccgaagc ttacattgac agcactctga   1140

ctgatgatca gggccccgtc ctgatgacca ctgtagccat gcctgtgttt agtaagcaga   1200

acgaaaccag atcgaagggc attcttctgg gagtggttgg cacagatgtc ccagtgaaag   1260

aacttctgaa gaccatcccc aaatacaagt tagggattca cggttatgcc tttgcaatca   1320

caaataatgg atatatcctg acgcatccgg aactcaggct gctgtacgaa gaaggaaaaa   1380

agcgaaggaa acctaactat agtagcgttg acctctctga ggtggagtgg gaagaccgag   1440

atgacgtgtt gagaaatgct atggtgaatc gaaagacggg gaagttttcc atggaggtga   1500

agaagacagt ggacaaaggg aaacgggttt tggtgatgac aaatgactac tattatacag   1560

acatcaaggg tactcctttc agtttaggtg tggcgctttc cagaggtcat gggaaatatt   1620

tcttccgagg gaatgtaacc atcgaagaag gcctgcatga cttagaacat cccgatgtgt   1680

ccttggcaga tgaatggtcc tactgcaaca ctgacctaca ccctgagcac cgccatctgt   1740

ctcagttaga agcgattaag ctctacctaa aaggcaaaga acctctgctc cagtgtgata   1800

aagaattgat ccaagaagtc ctttttgacg cggtggtgag tgcccccatt gaagcgtatt   1860

ggaccagcct ggccctcaac aaatctgaaa attctgacaa gggcgtggag gttgccttcc   1920

tcggcactcg cacgggcctc tccagaatca acctgtttgt cggggctgag cagctcacca   1980

atcaggactt cctgaaagct ggcgacaagg agaacatttt taacgcagac catttccctc   2040

tctggtaccg aagagccgct gagcagattc cagggagctt cgtctactcg atcccattca   2100

gcactggacc agtcaataaa agcaatgtgg tgacagcaag tacatccatc cagctcctgg   2160

atgaacggaa atctcctgtg gtggcagctg taggcattca gatgaaactt gaatttttcc   2220

aaaggaagtt ctggactgcc agcagacagt gtgcttccct ggatggcaaa tgctccatca   2280

gctgtgatga tgagactgtg aattgttacc tcatagacaa taatggattt attttggtgt   2340

ctgaagacta cacacagact ggagactttt ttggtgagat cgagggagct gtgatgaaca   2400

aattgctaac aatgggctcc tttaaaagaa ttacccttta tgactaccaa gccatgtgta   2460

gagccaacaa ggaaagcagc gatggcgccc atggcctcct ggatccttat aatgccttcc   2520

tctctgcagt aaaatggatc atgacagaac ttgtcttgtt cctggtggaa tttaacctct   2580

gcagttggtg gcactccgat atgacagcta aagcccagaa attgaaacag accctggagc   2640

cttgtgatac tgaatatcca gcattcgtct ctgagcgcac catcaaggag actacaggga   2700

atattgcttg tgaagactgc tccaagtcct ttgtcatcca gcaaatccca agcagcaacc   2760

tgttcatggt ggtggtggac agcagctgcc tctgtgaatc tgtggccccc atcaccatgg   2820

cacccattga aatcagtcaa cataatgaat cccttaagtg tgaacgtcta aaggcccaga   2880

agatcagaag gcgcccagaa tcttgtcatg gcttccatcc tgaggagaat gcaagggagt   2940

gtgggggtgc gccgagtctc caagcccaga cagtcctcct tctgctccct ctgcttttga   3000

tgctcttctc aaggtgacac tgactgagat gttctcttac tgactgagat gttctcttgg   3060

catgctaaat catggataaa ctgtgaacca aaatatggtg caacatacga gacatgaata   3120

tagtccaacc atcagcatct catcatgatt ttaaactgtg cgtgatataa actcttaaag   3180

atatgttgac aaaaagttat ctatcatctt tttactttgc cagtcatgca aatgtgagtt   3240

tgccacatga taatcaccct tcatcagaaa tgggaccgca agtggtaggc agtgtccctt   3300

ctgcttgaaa cctattgaaa ccaatttaaa actgtgtact ttttaaataa agtatattaa   3360

aatcataa                                                            3368


<210>  9416
<211>  909
<212>  PRT
<213>  Homosapiens

<400>  9416

Met Tyr Asn Lys Asp Pro Ala Ile Val Asn Gly Val Tyr Trp Ser Glu 
1               5                   10                  15      


Ser Leu Asn Lys Val Phe Val Asp Asn Phe Asp Arg Asp Pro Ser Leu 
            20                  25                  30          


Ile Trp Gln Tyr Phe Gly Ser Ala Lys Gly Phe Phe Arg Gln Tyr Pro 
        35                  40                  45              


Gly Ile Lys Trp Glu Pro Asp Glu Asn Gly Val Ile Ala Phe Asp Cys 
    50                  55                  60                  


Arg Asn Arg Lys Trp Tyr Ile Gln Ala Ala Thr Ser Pro Lys Asp Val 
65                  70                  75                  80  


Val Ile Leu Val Asp Val Ser Gly Ser Met Lys Gly Leu Arg Leu Thr 
                85                  90                  95      


Ile Ala Lys Gln Thr Val Ser Ser Ile Leu Asp Thr Leu Gly Asp Asp 
            100                 105                 110         


Asp Phe Phe Asn Ile Ile Ala Tyr Asn Glu Glu Leu His Tyr Val Glu 
        115                 120                 125             


Pro Cys Leu Asn Gly Thr Leu Val Gln Ala Asp Arg Thr Asn Lys Glu 
    130                 135                 140                 


His Phe Arg Glu His Leu Asp Lys Leu Phe Ala Lys Gly Ile Gly Met 
145                 150                 155                 160 


Leu Asp Ile Ala Leu Asn Glu Ala Phe Asn Ile Leu Ser Asp Phe Asn 
                165                 170                 175     


His Thr Gly Gln Gly Ser Ile Cys Ser Gln Ala Ile Met Leu Ile Thr 
            180                 185                 190         


Asp Gly Ala Val Asp Thr Tyr Asp Thr Ile Phe Ala Lys Tyr Asn Trp 
        195                 200                 205             


Pro Asp Arg Lys Val Arg Ile Phe Thr Tyr Leu Ile Gly Arg Glu Ala 
    210                 215                 220                 


Ala Phe Ala Asp Asn Leu Lys Trp Met Ala Cys Ala Asn Lys Gly Phe 
225                 230                 235                 240 


Phe Thr Gln Ile Ser Thr Leu Ala Asp Val Gln Glu Asn Val Met Glu 
                245                 250                 255     


Tyr Leu His Val Leu Ser Arg Pro Lys Val Ile Asp Gln Glu His Asp 
            260                 265                 270         


Val Val Trp Thr Glu Ala Tyr Ile Asp Ser Thr Leu Thr Asp Asp Gln 
        275                 280                 285             


Gly Pro Val Leu Met Thr Thr Val Ala Met Pro Val Phe Ser Lys Gln 
    290                 295                 300                 


Asn Glu Thr Arg Ser Lys Gly Ile Leu Leu Gly Val Val Gly Thr Asp 
305                 310                 315                 320 


Val Pro Val Lys Glu Leu Leu Lys Thr Ile Pro Lys Tyr Lys Leu Gly 
                325                 330                 335     


Ile His Gly Tyr Ala Phe Ala Ile Thr Asn Asn Gly Tyr Ile Leu Thr 
            340                 345                 350         


His Pro Glu Leu Arg Leu Leu Tyr Glu Glu Gly Lys Lys Arg Arg Lys 
        355                 360                 365             


Pro Asn Tyr Ser Ser Val Asp Leu Ser Glu Val Glu Trp Glu Asp Arg 
    370                 375                 380                 


Asp Asp Val Leu Arg Asn Ala Met Val Asn Arg Lys Thr Gly Lys Phe 
385                 390                 395                 400 


Ser Met Glu Val Lys Lys Thr Val Asp Lys Gly Lys Arg Val Leu Val 
                405                 410                 415     


Met Thr Asn Asp Tyr Tyr Tyr Thr Asp Ile Lys Gly Thr Pro Phe Ser 
            420                 425                 430         


Leu Gly Val Ala Leu Ser Arg Gly His Gly Lys Tyr Phe Phe Arg Gly 
        435                 440                 445             


Asn Val Thr Ile Glu Glu Gly Leu His Asp Leu Glu His Pro Asp Val 
    450                 455                 460                 


Ser Leu Ala Asp Glu Trp Ser Tyr Cys Asn Thr Asp Leu His Pro Glu 
465                 470                 475                 480 


His Arg His Leu Ser Gln Leu Glu Ala Ile Lys Leu Tyr Leu Lys Gly 
                485                 490                 495     


Lys Glu Pro Leu Leu Gln Cys Asp Lys Glu Leu Ile Gln Glu Val Leu 
            500                 505                 510         


Phe Asp Ala Val Val Ser Ala Pro Ile Glu Ala Tyr Trp Thr Ser Leu 
        515                 520                 525             


Ala Leu Asn Lys Ser Glu Asn Ser Asp Lys Gly Val Glu Val Ala Phe 
    530                 535                 540                 


Leu Gly Thr Arg Thr Gly Leu Ser Arg Ile Asn Leu Phe Val Gly Ala 
545                 550                 555                 560 


Glu Gln Leu Thr Asn Gln Asp Phe Leu Lys Ala Gly Asp Lys Glu Asn 
                565                 570                 575     


Ile Phe Asn Ala Asp His Phe Pro Leu Trp Tyr Arg Arg Ala Ala Glu 
            580                 585                 590         


Gln Ile Pro Gly Ser Phe Val Tyr Ser Ile Pro Phe Ser Thr Gly Pro 
        595                 600                 605             


Val Asn Lys Ser Asn Val Val Thr Ala Ser Thr Ser Ile Gln Leu Leu 
    610                 615                 620                 


Asp Glu Arg Lys Ser Pro Val Val Ala Ala Val Gly Ile Gln Met Lys 
625                 630                 635                 640 


Leu Glu Phe Phe Gln Arg Lys Phe Trp Thr Ala Ser Arg Gln Cys Ala 
                645                 650                 655     


Ser Leu Asp Gly Lys Cys Ser Ile Ser Cys Asp Asp Glu Thr Val Asn 
            660                 665                 670         


Cys Tyr Leu Ile Asp Asn Asn Gly Phe Ile Leu Val Ser Glu Asp Tyr 
        675                 680                 685             


Thr Gln Thr Gly Asp Phe Phe Gly Glu Ile Glu Gly Ala Val Met Asn 
    690                 695                 700                 


Lys Leu Leu Thr Met Gly Ser Phe Lys Arg Ile Thr Leu Tyr Asp Tyr 
705                 710                 715                 720 


Gln Ala Met Cys Arg Ala Asn Lys Glu Ser Ser Asp Gly Ala His Gly 
                725                 730                 735     


Leu Leu Asp Pro Tyr Asn Ala Phe Leu Ser Ala Val Lys Trp Ile Met 
            740                 745                 750         


Thr Glu Leu Val Leu Phe Leu Val Glu Phe Asn Leu Cys Ser Trp Trp 
        755                 760                 765             


His Ser Asp Met Thr Ala Lys Ala Gln Lys Leu Lys Gln Thr Leu Glu 
    770                 775                 780                 


Pro Cys Asp Thr Glu Tyr Pro Ala Phe Val Ser Glu Arg Thr Ile Lys 
785                 790                 795                 800 


Glu Thr Thr Gly Asn Ile Ala Cys Glu Asp Cys Ser Lys Ser Phe Val 
                805                 810                 815     


Ile Gln Gln Ile Pro Ser Ser Asn Leu Phe Met Val Val Val Asp Ser 
            820                 825                 830         


Ser Cys Leu Cys Glu Ser Val Ala Pro Ile Thr Met Ala Pro Ile Glu 
        835                 840                 845             


Ile Ser Gln His Asn Glu Ser Leu Lys Cys Glu Arg Leu Lys Ala Gln 
    850                 855                 860                 


Lys Ile Arg Arg Arg Pro Glu Ser Cys His Gly Phe His Pro Glu Glu 
865                 870                 875                 880 


Asn Ala Arg Glu Cys Gly Gly Ala Pro Ser Leu Gln Ala Gln Thr Val 
                885                 890                 895     


Leu Leu Leu Leu Pro Leu Leu Leu Met Leu Phe Ser Arg 
            900                 905                 


<210>  9417
<211>  3306
<212>  DNA
<213>  Homosapiens

<400>  9417
gttgactgtg acacgggtgt tacatatctt cctgtgcccc ttctccctgt agggtgaagc     60

tctgggcctc ggcttttggt ggggagataa aatccattgc tgctaagtac tccggttccc    120

agcttctgca aaagcagtat gaatacttca atgctgtgct gataaatgaa agggacaaag    180

acgggaattt tttggagctg ggaaaggaat tcatcttagc cccaaatgac cattttaata    240

atttgcctgt gaacatcagt ctaagtgacg tccaagtacc aacgaacatg tacaacaaag    300

accctgcaat tgtcaatggg gtttattggt ctgaatctct aaacaaagtt tttgtagata    360

actttgaccg tgacccatct ctcatatggc agtactttgg aagtgcaaag ggctttttta    420

ggcagtatcc ggggattaaa tgggaaccag atgagaatgg agtcattgcc ttcgactgca    480

ggaaccgaaa atggtacatc caggcagcaa cttctccgaa agacgtggtc attttagttg    540

acgtcagtgg cagcatgaaa ggactccgtc tgactatcgc gaagcaaaca gtctcatcca    600

ttttggatac acttggggat gatgacttct tcaacataat tgcttataat gaggagcttc    660

actatgtgga accttgcctg aatggaactt tggtgcaagc cgacaggaca aacaaagagc    720

acttcaggga gcatctggac aaacttttcg ccaaaggaat tggaatgttg gatatagctc    780

tgaatgaggc cttcaacatt ctgagtgatt tcaaccacac gggacaagga agtatctgca    840

gtcaggccat catgctcata actgatgggg cggtggacac ctatgataca atctttgcaa    900

aatacaattg gccagatcga aaggttcgca tcttcacata cctcattgga cgagaggctg    960

cgtttgcaga caatctaaag tggatggcct gtgccaacaa aggatttttt acccagatct   1020

ccaccttggc tgatgtgcag gagaatgtca tggaatacct tcacgtgctt agccggccca   1080

aagtcatcga ccaggagcat gatgtggtgt ggaccgaagc ttacattgac agcactctga   1140

ctgatgatca gggccccgtc ctgatgacca ctgtagccat gcctgtgttt agtaagcaga   1200

acgaaaccag atcgaagggc attcttctgg gagtggttgg cacagatgtc ccagtgaaag   1260

aacttctgaa gaccatcccc aaatacaagt tagggattca cggttatgcc tttgcaatca   1320

caaataatgg atatatcctg acgcatccgg aactcaggct gctgtacgaa gaaggaaaaa   1380

agcgaaggaa acctaactat agtagcgttg acctctctga ggtggagtgg gaagaccgag   1440

atgacgtgtt gagaaatgct atggtgaatc gaaagacggg gaagttttcc atggaggtga   1500

agaagacagt ggacaaaggg tttaggtgtg gcgctttcca gaggtcatgg gaaatatttc   1560

ttccgaggga atgtaaccat cgaagaaggc ctgcatgact tagaacatcc cgatgtgtcc   1620

ttggcagatg aatggtccta ctgcaacact gacctacacc ctgagcaccg ccatctgtct   1680

cagttagaag cgattaagct ctacctaaaa ggcaaagaac ctctgctcca gtgtgataaa   1740

gaattgatcc aagaagtcct ttttgacgcg gtggtgagtg cccccattga agcgtattgg   1800

accagcctgg ccctcaacaa atctgaaaat tctgacaagg gcgtggaggt tgccttcctc   1860

ggcactcgca cgggcctctc cagaatcaac ctgtttgtcg gggctgagca gctcaccaat   1920

caggacttcc tgaaagctgg cgacaaggag aacattttta acgcagacca tttccctctc   1980

tggtaccgaa gagccgctga gcagattcca gggagcttcg tctactcgat cccattcagc   2040

actggaccag tcaataaaag caatgtggtg acagcaagta catccatcca gctcctggat   2100

gaacggaaat ctcctgtggt ggcagctgta ggcattcaga tgaaacttga atttttccaa   2160

aggaagttct ggactgccag cagacagtgt gcttccctgg atggcaaatg ctccatcagc   2220

tgtgatgatg agactgtgaa ttgttacctc atagacaata atggatttat tttggtgtct   2280

gaagactaca cacagactgg agactttttt ggtgagatcg agggagctgt gatgaacaaa   2340

ttgctaacaa tgggctcctt taaaagaatt accctttatg actaccaagc catgtgtaga   2400

gccaacaagg aaagcagcga tggcgcccat ggcctcctgg atccttataa tgccttcctc   2460

tctgcagtaa aatggatcat gacagaactt gtcttgttcc tggtggaatt taacctctgc   2520

agttggtggc actccgatat gacagctaaa gcccagaaat tgaaacagac cctggagcct   2580

tgtgatactg aatatccagc attcgtctct gagcgcacca tcaaggagac tacagggaat   2640

attgcttgtg aagactgctc caagtccttt gtcatccagc aaatcccaag cagcaacctg   2700

ttcatggtgg tggtggacag cagctgcctc tgtgaatctg tggcccccat caccatggca   2760

cccattgaaa tcagtcaaca taatgaatcc cttaagtgtg aacgtctaaa ggcccagaag   2820

atcagaaggc gcccagaatc ttgtcatggc ttccatcctg aggagaatgc aagggagtgt   2880

gggggtgcgc cgagtctcca agcccagaca gtcctccttc tgctccctct gcttttgatg   2940

ctcttctcaa ggtgacactg actgagatgt tctcttactg actgagatgt tctcttggca   3000

tgctaaatca tggataaact gtgaaccaaa atatggtgca acatacgaga catgaatata   3060

gtccaaccat cagcatctca tcatgatttt aaactgtgcg tgatataaac tcttaaagat   3120

atgttgacaa aaagttatct atcatctttt tactttgcca gtcatgcaaa tgtgagtttg   3180

ccacatgata atcacccttc atcagaaatg ggaccgcaag tggtaggcag tgtcccttct   3240

gcttgaaacc tattgaaacc aatttaaaac tgtgtacttt ttaaataaag tatattaaaa   3300

tcataa                                                              3306


<210>  9418
<211>  436
<212>  PRT
<213>  Homosapiens

<400>  9418

Met Tyr Asn Lys Asp Pro Ala Ile Val Asn Gly Val Tyr Trp Ser Glu 
1               5                   10                  15      


Ser Leu Asn Lys Val Phe Val Asp Asn Phe Asp Arg Asp Pro Ser Leu 
            20                  25                  30          


Ile Trp Gln Tyr Phe Gly Ser Ala Lys Gly Phe Phe Arg Gln Tyr Pro 
        35                  40                  45              


Gly Ile Lys Trp Glu Pro Asp Glu Asn Gly Val Ile Ala Phe Asp Cys 
    50                  55                  60                  


Arg Asn Arg Lys Trp Tyr Ile Gln Ala Ala Thr Ser Pro Lys Asp Val 
65                  70                  75                  80  


Val Ile Leu Val Asp Val Ser Gly Ser Met Lys Gly Leu Arg Leu Thr 
                85                  90                  95      


Ile Ala Lys Gln Thr Val Ser Ser Ile Leu Asp Thr Leu Gly Asp Asp 
            100                 105                 110         


Asp Phe Phe Asn Ile Ile Ala Tyr Asn Glu Glu Leu His Tyr Val Glu 
        115                 120                 125             


Pro Cys Leu Asn Gly Thr Leu Val Gln Ala Asp Arg Thr Asn Lys Glu 
    130                 135                 140                 


His Phe Arg Glu His Leu Asp Lys Leu Phe Ala Lys Gly Ile Gly Met 
145                 150                 155                 160 


Leu Asp Ile Ala Leu Asn Glu Ala Phe Asn Ile Leu Ser Asp Phe Asn 
                165                 170                 175     


His Thr Gly Gln Gly Ser Ile Cys Ser Gln Ala Ile Met Leu Ile Thr 
            180                 185                 190         


Asp Gly Ala Val Asp Thr Tyr Asp Thr Ile Phe Ala Lys Tyr Asn Trp 
        195                 200                 205             


Pro Asp Arg Lys Val Arg Ile Phe Thr Tyr Leu Ile Gly Arg Glu Ala 
    210                 215                 220                 


Ala Phe Ala Asp Asn Leu Lys Trp Met Ala Cys Ala Asn Lys Gly Phe 
225                 230                 235                 240 


Phe Thr Gln Ile Ser Thr Leu Ala Asp Val Gln Glu Asn Val Met Glu 
                245                 250                 255     


Tyr Leu His Val Leu Ser Arg Pro Lys Val Ile Asp Gln Glu His Asp 
            260                 265                 270         


Val Val Trp Thr Glu Ala Tyr Ile Asp Ser Thr Leu Thr Asp Asp Gln 
        275                 280                 285             


Gly Pro Val Leu Met Thr Thr Val Ala Met Pro Val Phe Ser Lys Gln 
    290                 295                 300                 


Asn Glu Thr Arg Ser Lys Gly Ile Leu Leu Gly Val Val Gly Thr Asp 
305                 310                 315                 320 


Val Pro Val Lys Glu Leu Leu Lys Thr Ile Pro Lys Tyr Lys Leu Gly 
                325                 330                 335     


Ile His Gly Tyr Ala Phe Ala Ile Thr Asn Asn Gly Tyr Ile Leu Thr 
            340                 345                 350         


His Pro Glu Leu Arg Leu Leu Tyr Glu Glu Gly Lys Lys Arg Arg Lys 
        355                 360                 365             


Pro Asn Tyr Ser Ser Val Asp Leu Ser Glu Val Glu Trp Glu Asp Arg 
    370                 375                 380                 


Asp Asp Val Leu Arg Asn Ala Met Val Asn Arg Lys Thr Gly Lys Phe 
385                 390                 395                 400 


Ser Met Glu Val Lys Lys Thr Val Asp Lys Gly Phe Arg Cys Gly Ala 
                405                 410                 415     


Phe Gln Arg Ser Trp Glu Ile Phe Leu Pro Arg Glu Cys Asn His Arg 
            420                 425                 430         


Arg Arg Pro Ala 
        435     


<210>  9419
<211>  1147
<212>  DNA
<213>  Homosapiens

<400>  9419
cggctccgag gaccgggcag cgcatttggg gtgcccgcta cagggccccc caagaggctg     60

ccaggtcggg agcgcagcct gaggccacgg ggggaagggg gtgggtgggc tgagagcagc    120

tcggcggcga gactggcccg ccgccccttc cccccacacc cgtcgacctt gtgggcagaa    180

gcttcccaga gctccttagg ccggcgcgat ggcgactgct gtggagacgg aggcctgtca    240

gccgacggat gcgagttggg aaagtggcgg cggcggagac gacgagatga agcaggcgct    300

tccggagctt gagtcctccc aacaaaatgg cggcggcggc ggcctcaaca tcgctgagcc    360

cagcggcggc gctgggcgtg aggagaacgc gggggccgag gccgcccaga gcctcagcca    420

cgagcagcct caggactcct ctgaggcggg cgcggccgcc ctgcccagag gccccgaaga    480

gcccgaaagg cctgttagga ggagttttca gatccccagg aagagcagag aaaagaaagc    540

acttttccag ccattaactc caggctctcg agaatttgaa gatgttgtaa atattctcca    600

ttcttcttac cttgaaccaa cctcagtaac aaattttaac tacagacgtg cttgcttggt    660

acacaatgag cttttggaaa aggagtttac agaaaagcga agagaactga agtttgatgg    720

tcgtttagat aaggaacttt cagaatccta tgcatttctg atggttgatc gataccaggt    780

tcaaaccata tgtgaaaaag gattacatgt gggtcagtcc aaaataacaa ttcttggcag    840

tccttccatg ggtgtctatc tttctaggta tgctgattta ttacaagcga atcctttgga    900

cacgggggca atgggtgatg ttgttatttt taaaataatg aagggtaaaa taaagagtat    960

atatgacccc atgggtgtaa aaagtttgga atctatgtta aataagagtg ctttggaccc   1020

cacaccaaag catgaatgtc acgtgtcaaa gaatgccaat cgaattacat cacttttggc   1080

ttacagagcc tatgagctta ctcagtagat aaatataact ataccttgtg gaaaggacag   1140

cttttaa                                                             1147


<210>  9420
<211>  299
<212>  PRT
<213>  Homosapiens

<400>  9420

Met Ala Thr Ala Val Glu Thr Glu Ala Cys Gln Pro Thr Asp Ala Ser 
1               5                   10                  15      


Trp Glu Ser Gly Gly Gly Gly Asp Asp Glu Met Lys Gln Ala Leu Pro 
            20                  25                  30          


Glu Leu Glu Ser Ser Gln Gln Asn Gly Gly Gly Gly Gly Leu Asn Ile 
        35                  40                  45              


Ala Glu Pro Ser Gly Gly Ala Gly Arg Glu Glu Asn Ala Gly Ala Glu 
    50                  55                  60                  


Ala Ala Gln Ser Leu Ser His Glu Gln Pro Gln Asp Ser Ser Glu Ala 
65                  70                  75                  80  


Gly Ala Ala Ala Leu Pro Arg Gly Pro Glu Glu Pro Glu Arg Pro Val 
                85                  90                  95      


Arg Arg Ser Phe Gln Ile Pro Arg Lys Ser Arg Glu Lys Lys Ala Leu 
            100                 105                 110         


Phe Gln Pro Leu Thr Pro Gly Ser Arg Glu Phe Glu Asp Val Val Asn 
        115                 120                 125             


Ile Leu His Ser Ser Tyr Leu Glu Pro Thr Ser Val Thr Asn Phe Asn 
    130                 135                 140                 


Tyr Arg Arg Ala Cys Leu Val His Asn Glu Leu Leu Glu Lys Glu Phe 
145                 150                 155                 160 


Thr Glu Lys Arg Arg Glu Leu Lys Phe Asp Gly Arg Leu Asp Lys Glu 
                165                 170                 175     


Leu Ser Glu Ser Tyr Ala Phe Leu Met Val Asp Arg Tyr Gln Val Gln 
            180                 185                 190         


Thr Ile Cys Glu Lys Gly Leu His Val Gly Gln Ser Lys Ile Thr Ile 
        195                 200                 205             


Leu Gly Ser Pro Ser Met Gly Val Tyr Leu Ser Arg Tyr Ala Asp Leu 
    210                 215                 220                 


Leu Gln Ala Asn Pro Leu Asp Thr Gly Ala Met Gly Asp Val Val Ile 
225                 230                 235                 240 


Phe Lys Ile Met Lys Gly Lys Ile Lys Ser Ile Tyr Asp Pro Met Gly 
                245                 250                 255     


Val Lys Ser Leu Glu Ser Met Leu Asn Lys Ser Ala Leu Asp Pro Thr 
            260                 265                 270         


Pro Lys His Glu Cys His Val Ser Lys Asn Ala Asn Arg Ile Thr Ser 
        275                 280                 285             


Leu Leu Ala Tyr Arg Ala Tyr Glu Leu Thr Gln 
    290                 295                 


<210>  9421
<211>  226
<212>  DNA
<213>  Homosapiens

<400>  9421
agacactatt taataagggt caagaatgta acagtcaaaa caggtcacta ctgaaaacat     60

aatgttccac ttgtacatac tcctaaaggt aacagatgca gcgaaccgtt atctttttta    120

tacatgatta ttagacttta aaagacatgt caaatgacag agccattcat ccattcattt    180

gttcttcaca gtaagatctt tttttaaaat cacttttctt cattct                   226


<210>  9422
<211>  3587
<212>  DNA
<213>  Homosapiens

<400>  9422
agtcgagtcc tgcccggcta gaagccggct gtcggtctcc gtgtcgccgc cgccgcccgg     60

catcgtggag ctggggcccc cttttgcctg ggagttttgt agtcgcctag ggtcagcggt    120

gacatcccaa agggcaggcc cggcagccgc catggtggcc aaggattacc ccttctacct    180

cacggtcaag agagcgaact gcagcctgga gctacccccg gccagcggtc cggccaagga    240

cgctgaggag cctagtaata aacgggtcaa acccctttcc cgagtcacgt cgctagcaaa    300

cctcatcccg cccgtgaagg ccacgccatt aaagcgcttc agtcaaaccc tgcagcgctc    360

cattagcttc cgcagtgaga gccgccctga catcctcgcc ccccgaccct ggtccagaaa    420

tgccgccccc tcgagcacga aacggagaga tagcaagctg tggagtgaga ccttcgatgt    480

gtgcgtcaat cagatgctta catccaagga aatcaaacgt caggaggcga tctttgagct    540

ttcccaagga gaagaagact tgatagaaga cttgaaatta gcaaaaaagg cctatcatga    600

ccccatgctg aaactctcca taatgacaga acaagagttg aatcaaattt ttggaacact    660

ggactctcta attcctctac atgaagagct ccttagtcag cttcgagatg ttaggaagcc    720

tgatggctcg actgaacatg ttggtcccat cctcgtgggc tggctccctt gcctcagctc    780

ctatgatagc tactgcagca atcaagtagc cgccaaagct ctgctggacc acaaaaagca    840

agatcaccga gtccaggatt tcctacagcg atgtttagaa tcccccttta gccgcaaact    900

agatctctgg aatttcctcg atattccaag aagccgcctg gtaaaatacc ctctgcttct    960

ccgagaaatc ttgaggcaca caccaaatga taatccagat cagcagcact tggaagaagc   1020

tataaatatc attcagggaa ttgtggcaga aatcaacacc aagactggtg aatctgaatg   1080

ccgctattat aaagagcggc ttctttactt ggaagaaggc cagaaagact ccctgatcga   1140

cagctctcga gtcttgtgtt gtcatggtga actgaagaac aatcggggcg tgaaactgca   1200

tgttttcctg ttccaagaag tgcttgtgat cactcgagcc gtcacccaca atgagcagct   1260

ttgctaccag ctgtaccgtc agccaatccc cgtgaaagac ctcctgctgg aagacctcca   1320

ggatggagaa gtgaggctgg gtggctccct gcgaggggca ttcagcaaca atgagagaat   1380

taaaaacttc ttcagagtca gtttcaaaaa tggatcccaa agtcagaccc actcgctaca   1440

agccaatgac actttcaaca aacagcagtg gcttaactgt attcgtcaag ccaaagaaac   1500

agttttgtgt gctgccgggc aagctggggt gcttgactcc gagggatcgt tcctaaatcc   1560

caccaccggg agcagagagc tacagggaga aacaaaactt gagcagatgg accaatcgga   1620

cagtgagtca gactgtagta tggacacgag tgaggtcagc ctcgactgtg agcgcatgga   1680

acagacagac tcttcctgtg gaaacagcag gcacggtgaa agtaacgtct gacagaagca   1740

tgtgcacttc gggaagcagg cctgcatctt acctgtacag tatttgcatt ccacagatgg   1800

aacggtttgg agaagcactt tttcatactt ttgtgaaagt atacatgttg gcccagtctc   1860

tcgtatctgt acctttgtcc ctagtactgt aactgccaat ctgtctgtgt aagctggaat   1920

ctgtggcaac tattaccctg tgttgtattt cccaagtgtc tggatggatg gagaggtact   1980

caaacaagtt actttcagtt gtcctgctgg attttaaaaa aatagaaaaa gaatctcaaa   2040

actactgttt tacatagatt gtttgaagag tccttcctct tgtgcttctg taccactttc   2100

ccagctctta gatgtggtag ctaaaggcac ggaatttaga cggccttgta aatagggcat   2160

gaggaactca tctgtgtatt gggatggtat tagagagaga atcaggaaag accaactcat   2220

gaagtgaact tggtttgatc ttactcaact agaaagcttg aaaacatccc tggggattct   2280

gaaggcttaa ttttgcaaag gaggatgcat tgtctgaact ttgcaacttc atccagtgca   2340

agtttgatgc aagaatgtat taggacataa aatagaggct gaccttaaaa gggccaggac   2400

agaagcggct gccagctctg aatctttaac tgaaatgcac atggcaccag gaggtgtctc   2460

tcatagttgg ttgctagcct aaaacatcag aatagaaccc aaagggctta ggaaggcctg   2520

ccaggataac aagaaggccc tgtattcatt gtgtttcatc tgcctaggcc tactcattat   2580

tttagagaat gaatgaagca acaaggaaga gagaccatga ctctatcgat gacactgttt   2640

atagaaacac aggagaggaa gaatttggaa tgaaaagcac ttcgtcagaa ccttctgtgg   2700

gagccattga gagaaaagca tggtccagtg ccttctgaga aaggccagag ctttgggctt   2760

tcctgctctg cttttgggtc gtcaatttgc catctctggt tctgtgctat aatcagaatt   2820

gtaattatgt tctccagagg ccaatttcat taactctgat taattagaat cagctagcca   2880

gattagtaac ctctttgtcc agccttgatt tacagtgcag ggtaaagtgc agaccttaaa   2940

aacagctaag tacctagaag agctccctgc aagtgtaaat attaaggatg acctgtgcaa   3000

aattataccc acaccagcac tagtggtaat tattctaaat tattgccaaa aagttttttt   3060

taatctgtct ttcaagttta cagaaaagaa agcagtaaat gcattgatgt cattttatta   3120

tgtacatata tcatgtgcat tcaagctgtg tgacaagata tatcaatata aaaacaaggt   3180

atatacttta ttattttttg aaaacaagga tattgtgatc aattttaccc tgtaaaacat   3240

atttctgtat ttataggtct taaacatgat gaattttttc tattacaagt ttatttaaaa   3300

ctgctttctc aagtcgttat tgatacagca agtgaacctg ctgcagacag aagcagagga   3360

aagccaagaa cagcctttat tggtgaagaa aagaatgaat gattctttgt aggcgccatc   3420

agccactttt agaagccatc agccagtgtg ttgggaaaag aggtttgtca agtgttggcc   3480

tatgggaagg tggtcaatga atgttttgat gaaatgaatg tttttgtata atggccttaa   3540

acttttctgg aagtatttca aataaattac attattaagt catcctc                 3587


<210>  9423
<211>  526
<212>  PRT
<213>  Homosapiens

<400>  9423

Met Val Ala Lys Asp Tyr Pro Phe Tyr Leu Thr Val Lys Arg Ala Asn 
1               5                   10                  15      


Cys Ser Leu Glu Leu Pro Pro Ala Ser Gly Pro Ala Lys Asp Ala Glu 
            20                  25                  30          


Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Thr Ser Leu 
        35                  40                  45              


Ala Asn Leu Ile Pro Pro Val Lys Ala Thr Pro Leu Lys Arg Phe Ser 
    50                  55                  60                  


Gln Thr Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser Arg Pro Asp 
65                  70                  75                  80  


Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro Ser Ser Thr 
                85                  90                  95      


Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Thr Phe Asp Val Cys Val 
            100                 105                 110         


Asn Gln Met Leu Thr Ser Lys Glu Ile Lys Arg Gln Glu Ala Ile Phe 
        115                 120                 125             


Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu Lys Leu Ala 
    130                 135                 140                 


Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Thr Glu 
145                 150                 155                 160 


Gln Glu Leu Asn Gln Ile Phe Gly Thr Leu Asp Ser Leu Ile Pro Leu 
                165                 170                 175     


His Glu Glu Leu Leu Ser Gln Leu Arg Asp Val Arg Lys Pro Asp Gly 
            180                 185                 190         


Ser Thr Glu His Val Gly Pro Ile Leu Val Gly Trp Leu Pro Cys Leu 
        195                 200                 205             


Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln Val Ala Ala Lys Ala Leu 
    210                 215                 220                 


Leu Asp His Lys Lys Gln Asp His Arg Val Gln Asp Phe Leu Gln Arg 
225                 230                 235                 240 


Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp Asn Phe Leu 
                245                 250                 255     


Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu Leu Arg Glu 
            260                 265                 270         


Ile Leu Arg His Thr Pro Asn Asp Asn Pro Asp Gln Gln His Leu Glu 
        275                 280                 285             


Glu Ala Ile Asn Ile Ile Gln Gly Ile Val Ala Glu Ile Asn Thr Lys 
    290                 295                 300                 


Thr Gly Glu Ser Glu Cys Arg Tyr Tyr Lys Glu Arg Leu Leu Tyr Leu 
305                 310                 315                 320 


Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp Ser Ser Arg Val Leu Cys 
                325                 330                 335     


Cys His Gly Glu Leu Lys Asn Asn Arg Gly Val Lys Leu His Val Phe 
            340                 345                 350         


Leu Phe Gln Glu Val Leu Val Ile Thr Arg Ala Val Thr His Asn Glu 
        355                 360                 365             


Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro Ile Pro Val Lys Asp Leu 
    370                 375                 380                 


Leu Leu Glu Asp Leu Gln Asp Gly Glu Val Arg Leu Gly Gly Ser Leu 
385                 390                 395                 400 


Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile Lys Asn Phe Phe Arg Val 
                405                 410                 415     


Ser Phe Lys Asn Gly Ser Gln Ser Gln Thr His Ser Leu Gln Ala Asn 
            420                 425                 430         


Asp Thr Phe Asn Lys Gln Gln Trp Leu Asn Cys Ile Arg Gln Ala Lys 
        435                 440                 445             


Glu Thr Val Leu Cys Ala Ala Gly Gln Ala Gly Val Leu Asp Ser Glu 
    450                 455                 460                 


Gly Ser Phe Leu Asn Pro Thr Thr Gly Ser Arg Glu Leu Gln Gly Glu 
465                 470                 475                 480 


Thr Lys Leu Glu Gln Met Asp Gln Ser Asp Ser Glu Ser Asp Cys Ser 
                485                 490                 495     


Met Asp Thr Ser Glu Val Ser Leu Asp Cys Glu Arg Met Glu Gln Thr 
            500                 505                 510         


Asp Ser Ser Cys Gly Asn Ser Arg His Gly Glu Ser Asn Val 
        515                 520                 525     


<210>  9424
<211>  3628
<212>  DNA
<213>  Homosapiens

<400>  9424
gccgccgcag ccgccgccgc cgcggtgagt tttccagcct ggagaggccg aaccagcgcg     60

ggggtcgagg agacctgagc ctgccatact gagtctatgg acagttccac agcaatgaat    120

caatgcagct gtagaggaat ggaagaaaac aaggaaaggc ctaaacggca gcggcaaaac    180

aactttccca tgtttccctc tcctaaagcc tggaatttca gagggcgaaa acggaaacag    240

agcacccaag atgaagatgc tgttagcctt tgcagtctcg acataagtga gcctagtaat    300

aaacgggtca aacccctttc ccgagtcacg tcgctagcaa acctcatccc gcccgtgaag    360

gccacgccat taaagcgctt cagtcaaacc ctgcagcgct ccattagctt ccgcagtgag    420

agccgccctg acatcctcgc cccccgaccc tggtccagaa atgccgcccc ctcgagcacg    480

aaacggagag atagcaagct gtggagtgag accttcgatg tgtgcgtcaa tcagatgctt    540

acatccaagg aaatcaaacg tcaggaggcg atctttgagc tttcccaagg agaagaagac    600

ttgatagaag acttgaaatt agcaaaaaag gcctatcatg accccatgct gaaactctcc    660

ataatgacag aacaagagtt gaatcaaatt tttggaacac tggactctct aattcctcta    720

catgaagagc tccttagtca gcttcgagat gttaggaagc ctgatggctc gactgaacat    780

gttggtccca tcctcgtggg ctggctccct tgcctcagct cctatgatag ctactgcagc    840

aatcaagtag ccgccaaagc tctgctggac cacaaaaagc aagatcaccg agtccaggat    900

ttcctacagc gatgtttaga atcccccttt agccgcaaac tagatctctg gaatttcctc    960

gatattccaa gaagccgcct ggtaaaatac cctctgcttc tccgagaaat cttgaggcac   1020

acaccaaatg ataatccaga tcagcagcac ttggaagaag ctataaatat cattcaggga   1080

attgtggcag aaatcaacac caagactggt gaatctgaat gccgctatta taaagagcgg   1140

cttctttact tggaagaagg ccagaaagac tccctgatcg acagctctcg agtcttgtgt   1200

tgtcatggtg aactgaagaa caatcggggc gtgaaactgc atgttttcct gttccaagaa   1260

gtgcttgtga tcactcgagc cgtcacccac aatgagcagc tttgctacca gctgtaccgt   1320

cagccaatcc ccgtgaaaga cctcctgctg gaagacctcc aggatggaga agtgaggctg   1380

ggtggctccc tgcgaggggc attcagcaac aatgagagaa ttaaaaactt cttcagagtc   1440

agtttcaaaa atggatccca aagtcagacc cactcgctac aagccaatga cactttcaac   1500

aaacagcagt ggcttaactg tattcgtcaa gccaaagaaa cagttttgtg tgctgccggg   1560

caagctgggg tgcttgactc cgagggatcg ttcctaaatc ccaccaccgg gagcagagag   1620

ctacagggag aaacaaaact tgagcagatg gaccaatcgg acagtgagtc agactgtagt   1680

atggacacga gtgaggtcag cctcgactgt gagcgcatgg aacagacaga ctcttcctgt   1740

ggaaacagca ggcacggtga aagtaacgtc tgacagaagc atgtgcactt cgggaagcag   1800

gcctgcatct tacctgtaca gtatttgcat tccacagatg gaacggtttg gagaagcact   1860

ttttcatact tttgtgaaag tatacatgtt ggcccagtct ctcgtatctg tacctttgtc   1920

cctagtactg taactgccaa tctgtctgtg taagctggaa tctgtggcaa ctattaccct   1980

gtgttgtatt tcccaagtgt ctggatggat ggagaggtac tcaaacaagt tactttcagt   2040

tgtcctgctg gattttaaaa aaatagaaaa agaatctcaa aactactgtt ttacatagat   2100

tgtttgaaga gtccttcctc ttgtgcttct gtaccacttt cccagctctt agatgtggta   2160

gctaaaggca cggaatttag acggccttgt aaatagggca tgaggaactc atctgtgtat   2220

tgggatggta ttagagagag aatcaggaaa gaccaactca tgaagtgaac ttggtttgat   2280

cttactcaac tagaaagctt gaaaacatcc ctggggattc tgaaggctta attttgcaaa   2340

ggaggatgca ttgtctgaac tttgcaactt catccagtgc aagtttgatg caagaatgta   2400

ttaggacata aaatagaggc tgaccttaaa agggccagga cagaagcggc tgccagctct   2460

gaatctttaa ctgaaatgca catggcacca ggaggtgtct ctcatagttg gttgctagcc   2520

taaaacatca gaatagaacc caaagggctt aggaaggcct gccaggataa caagaaggcc   2580

ctgtattcat tgtgtttcat ctgcctaggc ctactcatta ttttagagaa tgaatgaagc   2640

aacaaggaag agagaccatg actctatcga tgacactgtt tatagaaaca caggagagga   2700

agaatttgga atgaaaagca cttcgtcaga accttctgtg ggagccattg agagaaaagc   2760

atggtccagt gccttctgag aaaggccaga gctttgggct ttcctgctct gcttttgggt   2820

cgtcaatttg ccatctctgg ttctgtgcta taatcagaat tgtaattatg ttctccagag   2880

gccaatttca ttaactctga ttaattagaa tcagctagcc agattagtaa cctctttgtc   2940

cagccttgat ttacagtgca gggtaaagtg cagaccttaa aaacagctaa gtacctagaa   3000

gagctccctg caagtgtaaa tattaaggat gacctgtgca aaattatacc cacaccagca   3060

ctagtggtaa ttattctaaa ttattgccaa aaagtttttt ttaatctgtc tttcaagttt   3120

acagaaaaga aagcagtaaa tgcattgatg tcattttatt atgtacatat atcatgtgca   3180

ttcaagctgt gtgacaagat atatcaatat aaaaacaagg tatatacttt attatttttt   3240

gaaaacaagg atattgtgat caattttacc ctgtaaaaca tatttctgta tttataggtc   3300

ttaaacatga tgaatttttt ctattacaag tttatttaaa actgctttct caagtcgtta   3360

ttgatacagc aagtgaacct gctgcagaca gaagcagagg aaagccaaga acagccttta   3420

ttggtgaaga aaagaatgaa tgattctttg taggcgccat cagccacttt tagaagccat   3480

cagccagtgt gttgggaaaa gaggtttgtc aagtgttggc ctatgggaag gtggtcaatg   3540

aatgttttga tgaaatgaat gtttttgtat aatggcctta aacttttctg gaagtatttc   3600

aaataaatta cattattaag tcatcctc                                      3628


<210>  9425
<211>  558
<212>  PRT
<213>  Homosapiens

<400>  9425

Met Asp Ser Ser Thr Ala Met Asn Gln Cys Ser Cys Arg Gly Met Glu 
1               5                   10                  15      


Glu Asn Lys Glu Arg Pro Lys Arg Gln Arg Gln Asn Asn Phe Pro Met 
            20                  25                  30          


Phe Pro Ser Pro Lys Ala Trp Asn Phe Arg Gly Arg Lys Arg Lys Gln 
        35                  40                  45              


Ser Thr Gln Asp Glu Asp Ala Val Ser Leu Cys Ser Leu Asp Ile Ser 
    50                  55                  60                  


Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Thr Ser Leu 
65                  70                  75                  80  


Ala Asn Leu Ile Pro Pro Val Lys Ala Thr Pro Leu Lys Arg Phe Ser 
                85                  90                  95      


Gln Thr Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser Arg Pro Asp 
            100                 105                 110         


Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro Ser Ser Thr 
        115                 120                 125             


Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Thr Phe Asp Val Cys Val 
    130                 135                 140                 


Asn Gln Met Leu Thr Ser Lys Glu Ile Lys Arg Gln Glu Ala Ile Phe 
145                 150                 155                 160 


Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu Lys Leu Ala 
                165                 170                 175     


Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Thr Glu 
            180                 185                 190         


Gln Glu Leu Asn Gln Ile Phe Gly Thr Leu Asp Ser Leu Ile Pro Leu 
        195                 200                 205             


His Glu Glu Leu Leu Ser Gln Leu Arg Asp Val Arg Lys Pro Asp Gly 
    210                 215                 220                 


Ser Thr Glu His Val Gly Pro Ile Leu Val Gly Trp Leu Pro Cys Leu 
225                 230                 235                 240 


Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln Val Ala Ala Lys Ala Leu 
                245                 250                 255     


Leu Asp His Lys Lys Gln Asp His Arg Val Gln Asp Phe Leu Gln Arg 
            260                 265                 270         


Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp Asn Phe Leu 
        275                 280                 285             


Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu Leu Arg Glu 
    290                 295                 300                 


Ile Leu Arg His Thr Pro Asn Asp Asn Pro Asp Gln Gln His Leu Glu 
305                 310                 315                 320 


Glu Ala Ile Asn Ile Ile Gln Gly Ile Val Ala Glu Ile Asn Thr Lys 
                325                 330                 335     


Thr Gly Glu Ser Glu Cys Arg Tyr Tyr Lys Glu Arg Leu Leu Tyr Leu 
            340                 345                 350         


Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp Ser Ser Arg Val Leu Cys 
        355                 360                 365             


Cys His Gly Glu Leu Lys Asn Asn Arg Gly Val Lys Leu His Val Phe 
    370                 375                 380                 


Leu Phe Gln Glu Val Leu Val Ile Thr Arg Ala Val Thr His Asn Glu 
385                 390                 395                 400 


Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro Ile Pro Val Lys Asp Leu 
                405                 410                 415     


Leu Leu Glu Asp Leu Gln Asp Gly Glu Val Arg Leu Gly Gly Ser Leu 
            420                 425                 430         


Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile Lys Asn Phe Phe Arg Val 
        435                 440                 445             


Ser Phe Lys Asn Gly Ser Gln Ser Gln Thr His Ser Leu Gln Ala Asn 
    450                 455                 460                 


Asp Thr Phe Asn Lys Gln Gln Trp Leu Asn Cys Ile Arg Gln Ala Lys 
465                 470                 475                 480 


Glu Thr Val Leu Cys Ala Ala Gly Gln Ala Gly Val Leu Asp Ser Glu 
                485                 490                 495     


Gly Ser Phe Leu Asn Pro Thr Thr Gly Ser Arg Glu Leu Gln Gly Glu 
            500                 505                 510         


Thr Lys Leu Glu Gln Met Asp Gln Ser Asp Ser Glu Ser Asp Cys Ser 
        515                 520                 525             


Met Asp Thr Ser Glu Val Ser Leu Asp Cys Glu Arg Met Glu Gln Thr 
    530                 535                 540                 


Asp Ser Ser Cys Gly Asn Ser Arg His Gly Glu Ser Asn Val 
545                 550                 555             


<210>  9426
<211>  529
<212>  DNA
<213>  Homosapiens

<400>  9426
gcacagggct ccactgcagt taggagccgg tgagtccggg tggatgaggt cagagcgccc     60

catggtgtgg tgctgcctct ttgtccccag ttcttccagg gatcacccca gaagaaaaca    120

gctgatactt acatctttgc tccaggatct gctttagggg aactccaaac taacagcagg    180

taaacataaa agaaagaaga cttactaaag aaagaagact ggccaggcgc tgtggctcat    240

gcctgtaatc tcagcacttt aggaggccaa ggcgagtgga tcacctgagg tcaggagttc    300

gagaccagcc tggccaacat ggtgaaaccc cctctccact aaaaatacaa aaatcagcca    360

gtgtggtggc acatgcctgt aatcccagct actcaggagg ccgaggcagg ctaattgctt    420

gaacctgggc agtggaggtt tcagtgagct gagattatgc cgctgcactc cagcctgggc    480

aacacagcgg gactccatct cataaataaa taaataagac atacctaaa                529


<210>  9427
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  9427

Met Arg Ser Glu Arg Pro Met Val Trp Cys Cys Leu Phe Val Pro Ser 
1               5                   10                  15      


Ser Ser Arg Asp His Pro Arg Arg Lys Gln Leu Ile Leu Thr Ser Leu 
            20                  25                  30          


Leu Gln Asp Leu Leu 
        35          


<210>  9428
<211>  357
<212>  DNA
<213>  Homosapiens

<400>  9428
accagaccca catgagacct ctatcagcag aactgctggt gaaaatgtga ggaatgtctc     60

tgtccttccc tgactcatca gacctcagga tgaccttcct tcctgacaca gccctcctgc    120

gcaagtaact caccatcttc ctgtgcccag ctaccaccag acacctgcag gtgagctcac    180

tgcaagcttg gcgtcgtggt gctgcgcaca gccctcttca gcacacagtg tcagcaccgt    240

cctataaaat ctccagccag cctttgtttc tttgcagtcg gcatctctca tgcaggctgc    300

cctgtctcct tgcaacctat ttttctactt tctccaataa atcagccttt ttctgcc       357


<210>  9429
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  9429

Leu Thr Ile Phe Leu Cys Pro Ala Thr Thr Arg His Leu Gln Val Ser 
1               5                   10                  15      


Ser Leu Gln Ala Trp Arg Arg Gly Ala Ala His Ser Pro Leu Gln His 
            20                  25                  30          


Thr Val Ser Ala Pro Ser Tyr Lys Ile Ser Ser Gln Pro Leu Phe Leu 
        35                  40                  45              


Cys Ser Arg His Leu Ser Cys Arg Leu Pro Cys Leu Leu Ala Thr Tyr 
    50                  55                  60                  


Phe Ser Thr Phe Ser Asn Lys Ser Ala Phe Phe 
65                  70                  75  


<210>  9430
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9430
gcggccaggg gcgggcggcc gcagagcagc accggccgtg gctccggtag cagcaagttc     60

gaaccccgct cccgctccgc ttcggttctc gctccttcgg cccttgggcc tccaaacacc    120

agtccccggc agctcgttgc gcattgcgct ctccccgcca ccaggatgcc ggtaaccgag    180

aaggatctag ctgaggacgc gccttggaag aagatccagc agaacacgtt cacacgctgg    240

tgcaacgagc acctcaagtg cgtgaacaaa cgcatcggca acctgcagac cgacctgagc    300

gacgggctgc ggctcatcgc gctgctcgag gtgctcagcc agaagcgcat gtaccgcaag    360

taccatcagc ggcccacctt tcgccagatg cagctcgaga atgtgtccgt ggcgctcgag    420

ttcctggacc gtgagagcat caagctcgtg tccatcgata gcaaagccat tgtggatggg    480

aacctgaagc tcatcttggg tctggtgtgg acgctgatcc tccactactc catctccatg    540

cccgtgtggg aggatgaagg ggatgatgat gccaagaagc agacgccaaa gcagaggctg    600

ctggggtgga ttcagaacaa gatcccctac ttgcccatca ccaactttaa ccagaactgg    660

caagacggca aagccctggg agccctggta gacagctgtg ctccaggtct gtgcccagac    720

tgggaatcct gggacccgca gaagcctgtg gataatgcac gagaagccat gcagcaggca    780

gatgactggc tgggtgtccc acaggtcatc actcctgaag aaatcattca cccggatgtg    840

gacgagcact cagttatgac ttacctgtcc cagttcccca aagccaagct caagccgggg    900

gctcctctca aacccaaact caacccgaag aaagccaggg cctatggcag aggaatcgag    960

cccactggaa acatggtgaa gcagccagcc aagttcactg tggacaccat cagcgccggg   1020

caaggagacg tgatggtgtt tgttgaggac ccagaaggga acaaagagga ggcacaagtg   1080

acccctgaca gtgacaagaa caagacatac tctgtggagt atctgcccaa ggtcaccggg   1140

ctacacaaag tcacagtcct ctttgcagga cagcacatct ccaagagccc atttgaagtg   1200

agtgttgaca aggcccaggg agatgccagt aaagtcactg caaaaggtcc agggttggaa   1260

gctgtaggga acatcgccaa taagcccacc tactttgaca tctatacggc aggagctggt   1320

gtgggtgaca ttggtgtgga ggtggaagat ccccagggga agaacaccgt ggagttgctc   1380

gtggaagaca aaggaaacca ggtgtatcga tgtgtgtaca aacccatgca gcctggccct   1440

cacgtggtca agatcttctt tgctggggac actattccta agagtccctt cgttgtgcag   1500

gttggggaag cctgcaatcc aaatgcctgc cgggccagtg gccgaggcct acaacccaaa   1560

ggcgtccgta tccgggagac cacagatttc aaggttgaca ccaaagctgc aggaagtggg   1620

gagctcggtg taaccatgaa gggtcctaag ggtctggagg agctggtgaa gcagaaagac   1680

tttctggatg gggtctacgc attcgagtat taccccagca ccccggggag atacagcatt   1740

gccatcacat gggggggaca ccacattcca aagagcccct ttgaagttca agttggccct   1800

gaagcgggta tgcagaaagt ccgtgcttgg ggccctgggc tccatggtgg gattgtcggg   1860

cggtcagcgg acttcgtggt agaatccatt ggctctgaag tggggtctct ggggtttgcc   1920

attgaaggcc cctctcaggc aaagattgag tacaacgacc agaatgatgg atcgtgtgat   1980

gtcaaatact ggcccaagga gcctggcgaa tatgctgttc acatcatgtg tgacgacgaa   2040

gacatcaagg acagcccgta catggccttc atccacccag ccacgggagg ctacaaccct   2100

gatctggttc gagcatacgg gccaggtttg gagaaatctg gatgcattgt caacaacctg   2160

gccgagttca ctgtggatcc taaggatgct ggaaaagctc ccttaaagat atttgctcag   2220

gatggggaag gccaacgcat tgacatccag atgaagaacc ggatggacgg cacatatgca   2280

tgctcataca ccccggtgaa ggccatcaag cacaccattg ctgtggtctg gggaggcgtg   2340

aacatcccgc acagccccta cagggtcaac atcgggcaag gtagccatcc tcagaaggtc   2400

aaagtgtttg ggccaggtgt ggagagaagt ggtctgaagg caaatgaacc tacacacttc   2460

acggtggact gtactgaggc tggggaaggt gatgtcagtg ttggcattaa gtgtgatgcc   2520

cgggtgttaa gtgaagatga ggaagacgtg gattttgaca ttattcacaa tgccaatgat   2580

acgttcacag tcaaatatgt gcctcctgct gctgggcgat acactatcaa agttctcttt   2640

gcatctcagg aaatccccgc cagccctttc agagtcaaag ttgacccttc ccacgatgcc   2700

agcaaagtga aggcagaagg cccagggctc agcaaagcag gtgtggaaaa tgggaaaccg   2760

acccacttca ctgtctacac caagggggct gggaaagccc cgctcaacgt gcagttcaac   2820

agccctcttc ctggcgatgc agtgaaggat ttggatatca tcgataatta tgactactct   2880

cacacggtta aatatacacc cacccaacag ggcaacatgc aggttctggt gacttacggt   2940

ggcgatccca tccctaaaag ccctttcact gtgggtgttg ctgcaccgct ggatctgagc   3000

aagataaaac tcaatgggct ggaaaacagg gtggaagttg ggaaggatca ggagttcacc   3060

gttgatacca ggggggcagg aggccagggg aagctggacg tgacaatcct cagcccctct   3120

cggaaggtcg tgccatgcct agtgacacct gtgacaggcc gggagaacag cacggccaag   3180

ttcatccctc gggaggaggg gctgtatgct gtagacgtga cctacgatgg acaccctgtg   3240

cccgggagcc cctacacagt ggaggcctcg ctgccaccag atcccagcaa ggtgaaggcc   3300

cacggtcccg gcctcgaagg tggtctcgtg ggcaagcctg ccgagttcac catcgatacc   3360

aaaggagctg gtactggagg tctgggctta acggtggaag gtccgtgcga ggccaaaatc   3420

gagtgctccg acaatggtga tgggacctgc tccgtctctt accttcccac aaaacccggg   3480

gagtacttcg tcaacatcct ctttgaagaa gtccacatac ctgggtctcc cttcaaagct   3540

gacattgaaa tgccctttga cccctctaaa gtcgtggcat cggggccagg tctcgagcac   3600

gggaaggtgg gtgaagctgg cctccttagc gtcgactgct cggaagcggg accgggggcc   3660

ctgggcctgg aagctgtctc ggactcggga acaaaagccg aagtcagtat tcagaacaac   3720

aaagatggca cctacgcggt gacctacgtg cccctgacgg ccggcatgta cacgttgacc   3780

atgaagtatg gtggcgaact cgtgccacac ttccccgccc gggtcaaggt ggagcccgcc   3840

gtggacacca gcaggatcaa agtctttgga ccaggaatag aagggaaaga tgtgttccgg   3900

gaagctacca ccgactttac agttgactct cggccgctga cccaggttgg gggtgaccac   3960

atcaaggccc acattgccaa cccctcaggg gcctccaccg agtgctttgt cacagacaat   4020

gcggatggga cctaccaggt ggaatacaca ccctttgaga aaggtctcca tgtagtggag   4080

gtgacatatg atgacgtgcc tatcccaaac agtcccttca aggtggctgt cactgaaggc   4140

tgccagccat ctagggtgca agcccaagga cctggattga aagaggcctt taccaacaag   4200

cccaatgtct tcaccgtggt taccagaggc gcaggaattg gtgggcttgg cataactgtt   4260

gagggaccat cagagtcgaa gataaattgc agagacaaca aggatggcag ctgcagtgct   4320

gagtacattc ctttcgcacc gggggattac gatgttaata tcacatatgg aggagcccac   4380

atccccggca gccccttcag ggttcctgtg aaggatgttg tggaccccag caaggtcaag   4440

attgccggcc ccgggctggg ctcaggcgtc cgagcccgtg tcctgcagtc cttcacggtg   4500

gacagcagca aggctggcct ggctccgctg gaagtgaggg ttctgggccc acgaggcttg   4560

gtggagccag tgaacgtggt ggacaatgga gatggcacac acacagtaac ctacacccca   4620

tctcaggagg gaccttacat ggtctcagtt aaatatgctg atgaagagat tcctcgcagt   4680

cccttcaagg tcaaggtcct tcccacatat gatgccagca aagtgactgc cagtggcccc   4740

ggccttagtt cctatggtgt gcctgccagt ctacctgtgg actttgcaat tgatgcccga   4800

gatgccgggg aaggcctgct tgctgttcaa ataacggacc aagaaggaaa acccaaaaga   4860

gccattgtcc atgacaataa agatggcacg tatgctgtca cctacatccc cgacaagact   4920

gggcgctata tgattggagt cacctacggg ggtgacgaca tcccactttc tccttatcgc   4980

atccgagcca cacagacggg tgatgccagc aagtgcctgg ccacgggtcc tggaatcgcc   5040

tccactgtga aaactggcga agaagtaggc tttgtggttg atgccaagac tgccgggaag   5100

ggtaaagtga cctgcacggt tctgacccca gatggcactg aggccgaggc cgatgtcatt   5160

gagaatgaag atggaaccta tgacatcttc tacacagctg ccaagccggg cacatatgtg   5220

atctatgtgc gcttcggtgg tgttgatatt cctaacagcc ccttcactgt catggccaca   5280

gatggggaag tcacagccgt ggaggaggca ccggtaaatg catgtccccc tggattcagg   5340

ccctgggtga ccgaagaggc ctatgtccca gtgagtgaca tgaacggcct gggatttaag   5400

ccttttgacc tggtcattcc gtttgctgtc aggaaaggag aaatcactgg agaggtccac   5460

atgccttctg ggaagacagc cacacctgag attgtggaca acaaggacgg cacggtcact   5520

gttagatatg cccccactga ggtcgggctc catgagatgc acatcaaata catgggcagc   5580

cacatccctg agagcccact ccagttctac gtgaactacc ccaacagtgg aagtgtttct   5640

gcatacggtc caggcctcgt gtatggagtg gccaacaaaa ctgccacctt caccatcgtc   5700

acagaggatg caggagaagg tggtctggac ttggctattg agggcccctc aaaagcagaa   5760

atcagctgca ttgacaataa agatgggaca tgcacagtga cctacctgcc gactctgcca   5820

ggcgactaca gcattctggt caagtacaat gacaagcaca tccctggcag ccccttcaca   5880

gccaagatca cagatgacag caggcggtgc tcccaggtga agttgggctc agccgctgac   5940

ttcctgctcg acatcagtga gactgacctc agcagcctga cggccagcat taaggcccca   6000

tctggccgag acgagccctg tctcctgaag aggctgccca acaaccacat tggcatctcc   6060

ttcatccccc gggaagtggg cgaacatctg gtcagcatca agaaaaatgg caaccatgtg   6120

gccaacagcc ccgtgtctat catggtggtc cagtcggaga ttggtgacgc ccgccgagcc   6180

aaagtctatg gccgcggcct gtcagaaggc cggactttcg agatgtctga cttcatcgtg   6240

gacacaaggg atgcaggtta tggtggcata tccttggcgg tggaaggccc cagcaaagtg   6300

gacatccaga cggaggacct ggaagatggc acctgcaaag tctcctactt ccctaccgtg   6360

cctggggttt atatcgtctc caccaaattc gctgacgagc acgtgcctgg gagcccattt   6420

accgtgaaga tcagtgggga gggaagagtc aaagagagca tcacccgcac cagtcgggcc   6480

ccgtccgtgg ccactgtcgg gagcatttgt gacctgaacc tgaaaatccc agaaatcaac   6540

agcagtgata tgtcggccca cgtcaccagc ccctctggcc gtgtgactga ggcagagatt   6600

gtgcccatgg ggaagaactc acactgcgtc cggtttgtgc cccaggagat gggcgtgcac   6660

acggtcagcg tcaagtaccg tgggcagcac gtcaccggca gccccttcca gttcaccgtg   6720

gggccacttg gtgaaggagg cgcccacaag gtgcgggcag gaggccctgg cctggagaga   6780

ggagaagcgg gagtcccagc tgagttcagc atttggaccc gggaagcagg cgctggaggc   6840

ctctccatcg ctgttgaggg ccccagtaag gccgagatta cattcgatga ccataaaaat   6900

gggtcgtgcg gtgtatctta tattgcccaa gagcctggta actacgaggt gtccatcaag   6960

ttcaatgatg agcacatccc ggaaagcccc tacctggtgc cggtcatcgc accctccgac   7020

gacgcccgcc gcctcactgt tatgagcctt caggaatcgg gattaaaagt taaccagcca   7080

gcatcctttg ctataaggtt gaatggcgca aaaggcaaga ttgatgcaaa ggtgcacagc   7140

ccctctggag ccgtggagga gtgccacgtg tctgagctgg agccagataa gtatgctgtt   7200

cgcttcatcc ctcatgagaa tggtgtccac accatcgatg tcaagttcaa tgggagccac   7260

gtggttggaa gccccttcaa agtgcgcgtt ggggagcctg gacaagcggg gaaccctgcc   7320

ctggtgtccg cctatggcac gggactcgaa gggggcacca caggtatcca gtcggaattc   7380

tttattaaca ccacccgagc aggtccaggg acattatccg tcaccatcga aggcccatcc   7440

aaggttaaaa tggattgcca ggaaacacct gaagggtaca aagtcatgta cacccccatg   7500

gctcctggta actacctgat cagcgtcaaa tacggtgggc ccaaccacat cgtgggcagt   7560

cccttcaagg ccaaggtgac aggccagcgt ctagttagcc ctggctcagc caacgagacc   7620

tcatccatcc tggtggagtc agtgaccagg tcgtctacag agacctgcta tagcgccatt   7680

cccaaggcat cctcggacgc cagcaaggtg acctctaagg gggcagggct ctcaaaggcc   7740

tttgtgggcc agaagagttc cttcctggtg gactgcagca aagctggctc caacatgctg   7800

ctgatcgggg tccatgggcc caccaccccc tgcgaggagg tctccatgaa gcatgtaggc   7860

aaccagcaat acaacgtcac atacgtcgtc aaggagaggg gcgattatgt gctggctgtg   7920

aagtgggggg aggaacacat ccctggcagc ccttttcatg tcacagtgcc ttaaaacagt   7980

tttctcaaat cctggagaga gttcttgtgg ttgcttttgt tgcttgtttg taattcattt   8040

tatacaaagc cctccagcct gtttgtgggg ctgaaacccc atccctaaaa tattgctgtt   8100

gtaaaatgcc ttcagaaata agtcctagac tggactcttg agggacatat tggagaatct   8160

taagaaatgc aagcttgttc agggggctga ga                                 8192


<210>  9431
<211>  2602
<212>  PRT
<213>  Homosapiens

<400>  9431

Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys 
1               5                   10                  15      


Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys 
            20                  25                  30          


Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu 
        35                  40                  45              


Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg 
    50                  55                  60                  


Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val 
65                  70                  75                  80  


Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser 
                85                  90                  95      


Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly 
            100                 105                 110         


Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp 
        115                 120                 125             


Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg 
    130                 135                 140                 


Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn 
145                 150                 155                 160 


Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp 
                165                 170                 175     


Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln 
            180                 185                 190         


Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp 
        195                 200                 205             


Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp 
    210                 215                 220                 


Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala 
225                 230                 235                 240 


Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys 
                245                 250                 255     


Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys 
            260                 265                 270         


Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp 
        275                 280                 285             


Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln 
    290                 295                 300                 


Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu 
305                 310                 315                 320 


Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln 
                325                 330                 335     


His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly 
            340                 345                 350         


Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly 
        355                 360                 365             


Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala 
    370                 375                 380                 


Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn 
385                 390                 395                 400 


Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys 
                405                 410                 415     


Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe 
            420                 425                 430         


Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu 
        435                 440                 445             


Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro 
    450                 455                 460                 


Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys 
465                 470                 475                 480 


Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly 
                485                 490                 495     


Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala 
            500                 505                 510         


Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr 
        515                 520                 525             


Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly 
    530                 535                 540                 


Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His 
545                 550                 555                 560 


Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly 
                565                 570                 575     


Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala 
            580                 585                 590         


Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr 
        595                 600                 605             


Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp 
    610                 615                 620                 


Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr 
625                 630                 635                 640 


Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu 
                645                 650                 655     


Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro 
            660                 665                 670         


Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu 
        675                 680                 685             


Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr 
    690                 695                 700                 


Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val 
705                 710                 715                 720 


Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile 
                725                 730                 735     


Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val 
            740                 745                 750         


Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp 
        755                 760                 765             


Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp 
    770                 775                 780                 


Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile 
785                 790                 795                 800 


His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala 
                805                 810                 815     


Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala 
            820                 825                 830         


Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val 
        835                 840                 845             


Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys 
    850                 855                 860                 


Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu 
865                 870                 875                 880 


Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu 
                885                 890                 895     


Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro 
            900                 905                 910         


Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro 
        915                 920                 925             


Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu 
    930                 935                 940                 


Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys 
945                 950                 955                 960 


Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys 
                965                 970                 975     


Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu 
            980                 985                 990         


Val Thr Pro Val Thr Gly Arg Glu  Asn Ser Thr Ala Lys  Phe Ile Pro 
        995                 1000                 1005             


Arg Glu  Glu Gly Leu Tyr Ala  Val Asp Val Thr Tyr  Asp Gly His 
    1010                 1015                 1020             


Pro Val  Pro Gly Ser Pro Tyr  Thr Val Glu Ala Ser  Leu Pro Pro 
    1025                 1030                 1035             


Asp Pro  Ser Lys Val Lys Ala  His Gly Pro Gly Leu  Glu Gly Gly 
    1040                 1045                 1050             


Leu Val  Gly Lys Pro Ala Glu  Phe Thr Ile Asp Thr  Lys Gly Ala 
    1055                 1060                 1065             


Gly Thr  Gly Gly Leu Gly Leu  Thr Val Glu Gly Pro  Cys Glu Ala 
    1070                 1075                 1080             


Lys Ile  Glu Cys Ser Asp Asn  Gly Asp Gly Thr Cys  Ser Val Ser 
    1085                 1090                 1095             


Tyr Leu  Pro Thr Lys Pro Gly  Glu Tyr Phe Val Asn  Ile Leu Phe 
    1100                 1105                 1110             


Glu Glu  Val His Ile Pro Gly  Ser Pro Phe Lys Ala  Asp Ile Glu 
    1115                 1120                 1125             


Met Pro  Phe Asp Pro Ser Lys  Val Val Ala Ser Gly  Pro Gly Leu 
    1130                 1135                 1140             


Glu His  Gly Lys Val Gly Glu  Ala Gly Leu Leu Ser  Val Asp Cys 
    1145                 1150                 1155             


Ser Glu  Ala Gly Pro Gly Ala  Leu Gly Leu Glu Ala  Val Ser Asp 
    1160                 1165                 1170             


Ser Gly  Thr Lys Ala Glu Val  Ser Ile Gln Asn Asn  Lys Asp Gly 
    1175                 1180                 1185             


Thr Tyr  Ala Val Thr Tyr Val  Pro Leu Thr Ala Gly  Met Tyr Thr 
    1190                 1195                 1200             


Leu Thr  Met Lys Tyr Gly Gly  Glu Leu Val Pro His  Phe Pro Ala 
    1205                 1210                 1215             


Arg Val  Lys Val Glu Pro Ala  Val Asp Thr Ser Arg  Ile Lys Val 
    1220                 1225                 1230             


Phe Gly  Pro Gly Ile Glu Gly  Lys Asp Val Phe Arg  Glu Ala Thr 
    1235                 1240                 1245             


Thr Asp  Phe Thr Val Asp Ser  Arg Pro Leu Thr Gln  Val Gly Gly 
    1250                 1255                 1260             


Asp His  Ile Lys Ala His Ile  Ala Asn Pro Ser Gly  Ala Ser Thr 
    1265                 1270                 1275             


Glu Cys  Phe Val Thr Asp Asn  Ala Asp Gly Thr Tyr  Gln Val Glu 
    1280                 1285                 1290             


Tyr Thr  Pro Phe Glu Lys Gly  Leu His Val Val Glu  Val Thr Tyr 
    1295                 1300                 1305             


Asp Asp  Val Pro Ile Pro Asn  Ser Pro Phe Lys Val  Ala Val Thr 
    1310                 1315                 1320             


Glu Gly  Cys Gln Pro Ser Arg  Val Gln Ala Gln Gly  Pro Gly Leu 
    1325                 1330                 1335             


Lys Glu  Ala Phe Thr Asn Lys  Pro Asn Val Phe Thr  Val Val Thr 
    1340                 1345                 1350             


Arg Gly  Ala Gly Ile Gly Gly  Leu Gly Ile Thr Val  Glu Gly Pro 
    1355                 1360                 1365             


Ser Glu  Ser Lys Ile Asn Cys  Arg Asp Asn Lys Asp  Gly Ser Cys 
    1370                 1375                 1380             


Ser Ala  Glu Tyr Ile Pro Phe  Ala Pro Gly Asp Tyr  Asp Val Asn 
    1385                 1390                 1395             


Ile Thr  Tyr Gly Gly Ala His  Ile Pro Gly Ser Pro  Phe Arg Val 
    1400                 1405                 1410             


Pro Val  Lys Asp Val Val Asp  Pro Ser Lys Val Lys  Ile Ala Gly 
    1415                 1420                 1425             


Pro Gly  Leu Gly Ser Gly Val  Arg Ala Arg Val Leu  Gln Ser Phe 
    1430                 1435                 1440             


Thr Val  Asp Ser Ser Lys Ala  Gly Leu Ala Pro Leu  Glu Val Arg 
    1445                 1450                 1455             


Val Leu  Gly Pro Arg Gly Leu  Val Glu Pro Val Asn  Val Val Asp 
    1460                 1465                 1470             


Asn Gly  Asp Gly Thr His Thr  Val Thr Tyr Thr Pro  Ser Gln Glu 
    1475                 1480                 1485             


Gly Pro  Tyr Met Val Ser Val  Lys Tyr Ala Asp Glu  Glu Ile Pro 
    1490                 1495                 1500             


Arg Ser  Pro Phe Lys Val Lys  Val Leu Pro Thr Tyr  Asp Ala Ser 
    1505                 1510                 1515             


Lys Val  Thr Ala Ser Gly Pro  Gly Leu Ser Ser Tyr  Gly Val Pro 
    1520                 1525                 1530             


Ala Ser  Leu Pro Val Asp Phe  Ala Ile Asp Ala Arg  Asp Ala Gly 
    1535                 1540                 1545             


Glu Gly  Leu Leu Ala Val Gln  Ile Thr Asp Gln Glu  Gly Lys Pro 
    1550                 1555                 1560             


Lys Arg  Ala Ile Val His Asp  Asn Lys Asp Gly Thr  Tyr Ala Val 
    1565                 1570                 1575             


Thr Tyr  Ile Pro Asp Lys Thr  Gly Arg Tyr Met Ile  Gly Val Thr 
    1580                 1585                 1590             


Tyr Gly  Gly Asp Asp Ile Pro  Leu Ser Pro Tyr Arg  Ile Arg Ala 
    1595                 1600                 1605             


Thr Gln  Thr Gly Asp Ala Ser  Lys Cys Leu Ala Thr  Gly Pro Gly 
    1610                 1615                 1620             


Ile Ala  Ser Thr Val Lys Thr  Gly Glu Glu Val Gly  Phe Val Val 
    1625                 1630                 1635             


Asp Ala  Lys Thr Ala Gly Lys  Gly Lys Val Thr Cys  Thr Val Leu 
    1640                 1645                 1650             


Thr Pro  Asp Gly Thr Glu Ala  Glu Ala Asp Val Ile  Glu Asn Glu 
    1655                 1660                 1665             


Asp Gly  Thr Tyr Asp Ile Phe  Tyr Thr Ala Ala Lys  Pro Gly Thr 
    1670                 1675                 1680             


Tyr Val  Ile Tyr Val Arg Phe  Gly Gly Val Asp Ile  Pro Asn Ser 
    1685                 1690                 1695             


Pro Phe  Thr Val Met Ala Thr  Asp Gly Glu Val Thr  Ala Val Glu 
    1700                 1705                 1710             


Glu Ala  Pro Val Asn Ala Cys  Pro Pro Gly Phe Arg  Pro Trp Val 
    1715                 1720                 1725             


Thr Glu  Glu Ala Tyr Val Pro  Val Ser Asp Met Asn  Gly Leu Gly 
    1730                 1735                 1740             


Phe Lys  Pro Phe Asp Leu Val  Ile Pro Phe Ala Val  Arg Lys Gly 
    1745                 1750                 1755             


Glu Ile  Thr Gly Glu Val His  Met Pro Ser Gly Lys  Thr Ala Thr 
    1760                 1765                 1770             


Pro Glu  Ile Val Asp Asn Lys  Asp Gly Thr Val Thr  Val Arg Tyr 
    1775                 1780                 1785             


Ala Pro  Thr Glu Val Gly Leu  His Glu Met His Ile  Lys Tyr Met 
    1790                 1795                 1800             


Gly Ser  His Ile Pro Glu Ser  Pro Leu Gln Phe Tyr  Val Asn Tyr 
    1805                 1810                 1815             


Pro Asn  Ser Gly Ser Val Ser  Ala Tyr Gly Pro Gly  Leu Val Tyr 
    1820                 1825                 1830             


Gly Val  Ala Asn Lys Thr Ala  Thr Phe Thr Ile Val  Thr Glu Asp 
    1835                 1840                 1845             


Ala Gly  Glu Gly Gly Leu Asp  Leu Ala Ile Glu Gly  Pro Ser Lys 
    1850                 1855                 1860             


Ala Glu  Ile Ser Cys Ile Asp  Asn Lys Asp Gly Thr  Cys Thr Val 
    1865                 1870                 1875             


Thr Tyr  Leu Pro Thr Leu Pro  Gly Asp Tyr Ser Ile  Leu Val Lys 
    1880                 1885                 1890             


Tyr Asn  Asp Lys His Ile Pro  Gly Ser Pro Phe Thr  Ala Lys Ile 
    1895                 1900                 1905             


Thr Asp  Asp Ser Arg Arg Cys  Ser Gln Val Lys Leu  Gly Ser Ala 
    1910                 1915                 1920             


Ala Asp  Phe Leu Leu Asp Ile  Ser Glu Thr Asp Leu  Ser Ser Leu 
    1925                 1930                 1935             


Thr Ala  Ser Ile Lys Ala Pro  Ser Gly Arg Asp Glu  Pro Cys Leu 
    1940                 1945                 1950             


Leu Lys  Arg Leu Pro Asn Asn  His Ile Gly Ile Ser  Phe Ile Pro 
    1955                 1960                 1965             


Arg Glu  Val Gly Glu His Leu  Val Ser Ile Lys Lys  Asn Gly Asn 
    1970                 1975                 1980             


His Val  Ala Asn Ser Pro Val  Ser Ile Met Val Val  Gln Ser Glu 
    1985                 1990                 1995             


Ile Gly  Asp Ala Arg Arg Ala  Lys Val Tyr Gly Arg  Gly Leu Ser 
    2000                 2005                 2010             


Glu Gly  Arg Thr Phe Glu Met  Ser Asp Phe Ile Val  Asp Thr Arg 
    2015                 2020                 2025             


Asp Ala  Gly Tyr Gly Gly Ile  Ser Leu Ala Val Glu  Gly Pro Ser 
    2030                 2035                 2040             


Lys Val  Asp Ile Gln Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Lys 
    2045                 2050                 2055             


Val Ser  Tyr Phe Pro Thr Val  Pro Gly Val Tyr Ile  Val Ser Thr 
    2060                 2065                 2070             


Lys Phe  Ala Asp Glu His Val  Pro Gly Ser Pro Phe  Thr Val Lys 
    2075                 2080                 2085             


Ile Ser  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Thr Ser 
    2090                 2095                 2100             


Arg Ala  Pro Ser Val Ala Thr  Val Gly Ser Ile Cys  Asp Leu Asn 
    2105                 2110                 2115             


Leu Lys  Ile Pro Glu Ile Asn  Ser Ser Asp Met Ser  Ala His Val 
    2120                 2125                 2130             


Thr Ser  Pro Ser Gly Arg Val  Thr Glu Ala Glu Ile  Val Pro Met 
    2135                 2140                 2145             


Gly Lys  Asn Ser His Cys Val  Arg Phe Val Pro Gln  Glu Met Gly 
    2150                 2155                 2160             


Val His  Thr Val Ser Val Lys  Tyr Arg Gly Gln His  Val Thr Gly 
    2165                 2170                 2175             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2180                 2185                 2190             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Gly Glu Ala 
    2195                 2200                 2205             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2210                 2215                 2220             


Gly Gly  Leu Ser Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2225                 2230                 2235             


Thr Phe  Asp Asp His Lys Asn  Gly Ser Cys Gly Val  Ser Tyr Ile 
    2240                 2245                 2250             


Ala Gln  Glu Pro Gly Asn Tyr  Glu Val Ser Ile Lys  Phe Asn Asp 
    2255                 2260                 2265             


Glu His  Ile Pro Glu Ser Pro  Tyr Leu Val Pro Val  Ile Ala Pro 
    2270                 2275                 2280             


Ser Asp  Asp Ala Arg Arg Leu  Thr Val Met Ser Leu  Gln Glu Ser 
    2285                 2290                 2295             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Ile  Arg Leu Asn 
    2300                 2305                 2310             


Gly Ala  Lys Gly Lys Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2315                 2320                 2325             


Ala Val  Glu Glu Cys His Val  Ser Glu Leu Glu Pro  Asp Lys Tyr 
    2330                 2335                 2340             


Ala Val  Arg Phe Ile Pro His  Glu Asn Gly Val His  Thr Ile Asp 
    2345                 2350                 2355             


Val Lys  Phe Asn Gly Ser His  Val Val Gly Ser Pro  Phe Lys Val 
    2360                 2365                 2370             


Arg Val  Gly Glu Pro Gly Gln  Ala Gly Asn Pro Ala  Leu Val Ser 
    2375                 2380                 2385             


Ala Tyr  Gly Thr Gly Leu Glu  Gly Gly Thr Thr Gly  Ile Gln Ser 
    2390                 2395                 2400             


Glu Phe  Phe Ile Asn Thr Thr  Arg Ala Gly Pro Gly  Thr Leu Ser 
    2405                 2410                 2415             


Val Thr  Ile Glu Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2420                 2425                 2430             


Thr Pro  Glu Gly Tyr Lys Val  Met Tyr Thr Pro Met  Ala Pro Gly 
    2435                 2440                 2445             


Asn Tyr  Leu Ile Ser Val Lys  Tyr Gly Gly Pro Asn  His Ile Val 
    2450                 2455                 2460             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Gln Arg  Leu Val Ser 
    2465                 2470                 2475             


Pro Gly  Ser Ala Asn Glu Thr  Ser Ser Ile Leu Val  Glu Ser Val 
    2480                 2485                 2490             


Thr Arg  Ser Ser Thr Glu Thr  Cys Tyr Ser Ala Ile  Pro Lys Ala 
    2495                 2500                 2505             


Ser Ser  Asp Ala Ser Lys Val  Thr Ser Lys Gly Ala  Gly Leu Ser 
    2510                 2515                 2520             


Lys Ala  Phe Val Gly Gln Lys  Ser Ser Phe Leu Val  Asp Cys Ser 
    2525                 2530                 2535             


Lys Ala  Gly Ser Asn Met Leu  Leu Ile Gly Val His  Gly Pro Thr 
    2540                 2545                 2550             


Thr Pro  Cys Glu Glu Val Ser  Met Lys His Val Gly  Asn Gln Gln 
    2555                 2560                 2565             


Tyr Asn  Val Thr Tyr Val Val  Lys Glu Arg Gly Asp  Tyr Val Leu 
    2570                 2575                 2580             


Ala Val  Lys Trp Gly Glu Glu  His Ile Pro Gly Ser  Pro Phe His 
    2585                 2590                 2595             


Val Thr  Val Pro 
    2600         


<210>  9432
<211>  344
<212>  DNA
<213>  Homosapiens

<400>  9432
acgcatcctg ccatctgggg tgaggctaga cccattttac agataagggg gtccggaggg     60

ttaattgacc tgtccaaggt cagcaagtag ggcccagctg agaactgaag gaagtgggca    120

acagttagaa ggaggctttg ttttcctctc ctctcccaaa cctacaccag ggtcttcctg    180

aaaggaggga gggaattggt gtctcttgct ggactgggcc ttctggtctg gggaggaaga    240

ataaggatga agtctccctt gtggtctgag atagttggag gttgcagtga gccgaggtct    300

ttgtgtaact gcactccagc ctgggagagc gagactctga ctca                     344


<210>  9433
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  9433

Met Lys Ser Pro Leu Trp Ser Glu Ile Val Gly Gly Cys Ser Glu Pro 
1               5                   10                  15      


Arg Ser Leu Cys Asn Cys Thr Pro Ala Trp Glu Ser Glu Thr Leu 
            20                  25                  30      


<210>  9434
<211>  856
<212>  DNA
<213>  Homosapiens

<400>  9434
agggactggc cctggcctgt gatttgggtc tcttcctgag gaaaccaggt cactatagtg     60

accctagtga caggaagaaa gggagatggg tgtggctgcc aggactttct ccagtggaaa    120

agggattccc tctaggctga gcctcccctg ggccttaggg cctcaccctt cccttccccc    180

acacctgtcc tggcaggtaa ggctgcttcc tgcttcctgg gcccagatgg cagccgcacc    240

acccagctga tctccagcag ccctccccct ccccaagggt ggcttccctg cagaagaatc    300

tgcatggcac gctgttgtct tctttctggg gtccatctcc tgtactgggg agggagaacc    360

tcagaatctc ctggaattct ttaccattca gaaaccagcc tcccctctga agaatcccaa    420

ggcccagctg ggctcaattt ggatctgttc tttgttttaa aaatgtgtat ttatttaatt    480

aactgaataa agaaacttaa agtaaaccag aagtatccaa atacgacatg aaatctctaa    540

aacaacaaca aaaccaaacc aaaccgcagc actagcaaat cacagactgc ctgatctacc    600

cactgtttac agaggcagca gctacttcca gcactgtctc tcatcagtgc ccggggctgt    660

gggtctcatt ctagattttg tctacatttt tttacatggt tctcctgatt ccctgctccc    720

cctccccacc accgccccgc ctggagatgg agccttgctc tgtctccagg ctggagttgc    780

agtgagccga ggtctttgtg taactgcact ccagcctggg agagcgagac tctgactcaa    840

aaaaaaaaaa aaaaaa                                                    856


<210>  9435
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  9435

Met Ala Arg Cys Cys Leu Leu Ser Gly Val His Leu Leu Tyr Trp Gly 
1               5                   10                  15      


Gly Arg Thr Ser Glu Ser Pro Gly Ile Leu Tyr His Ser Glu Thr Ser 
            20                  25                  30          


Leu Pro Ser Glu Glu Ser Gln Gly Pro Ala Gly Leu Asn Leu Asp Leu 
        35                  40                  45              


Phe Phe Val Leu Lys Met Cys Ile Tyr Leu Ile Asn 
    50                  55                  60  


<210>  9436
<211>  369
<212>  DNA
<213>  Homosapiens

<400>  9436
cccaggagag ggggctggaa gagagcgagc tgccattgta ttttggttgc tgtggatcta     60

aggagaagag atgtttagga gtctttccct ggcatggttc ctcctgcctt cacccatcac    120

tcttttcctc gagggattcc ctgtggggtg cacagcccca gggtgggcca gactgagctc    180

acaggagcat gggctgtgtt tcagatgtgg cctcagaatc cttctcaaca cagtgtacta    240

gcaccacttg gtgctcctga tctactgtat catctcttga aaaactacta acatgaaaag    300

acctgccaag tcaactttat attaactgaa cccttgacac agtgatggat aaaaattaat    360

tcaaacagc                                                            369


<210>  9437
<211>  65
<212>  PRT
<213>  Homosapiens

<400>  9437

Met Val Pro Pro Ala Phe Thr His His Ser Phe Pro Arg Gly Ile Pro 
1               5                   10                  15      


Cys Gly Val His Ser Pro Arg Val Gly Gln Thr Glu Leu Thr Gly Ala 
            20                  25                  30          


Trp Ala Val Phe Gln Met Trp Pro Gln Asn Pro Ser Gln His Ser Val 
        35                  40                  45              


Leu Ala Pro Leu Gly Ala Pro Asp Leu Leu Tyr His Leu Leu Lys Asn 
    50                  55                  60                  


Tyr 
65  


<210>  9438
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9438
actctagtcc tttacctcat gtgcttacaa aggcttttaa gataattcta ggtttgtgcc     60

tttgagcaag tggatttttg aatcacacag gatgctattc tagacttttt agatatatcc    120

aggaatagag taaaaaataa aatccctcct gcataaaggc accaggcttt ttccaagctt    180

tgtttatttt ttaacaccac ttcttcaagg aatggataat ccccatcttc atgcaagaac    240

atagcacccg gaggagaagt ctcagtctgt gcccagactg ggaatcctgg gacccgcaga    300

agcctgtgga taatgcacga gaagccatgc agcaggcaga tgactggctg ggtgtcccac    360

aggtcatcac tcctgaagaa atcattcacc cggatgtgga cgagcactca gttatgactt    420

acctgtccca gttccccaaa gccaagctca agccgggggc tcctctcaaa cccaaactca    480

acccgaagaa agccagggcc tatggcagag gaatcgagcc cactggaaac atggtgaagc    540

agccagccaa gttcactgtg gacaccatca gcgccgggca aggagacgtg atggtgtttg    600

ttgaggaccc agaagggaac aaagaggagg cacaagtgac ccctgacagt gacaagaaca    660

agacatactc tgtggagtat ctgcccaagg tcaccgggct acacaaagtc acagtcctct    720

ttgcaggaca gcacatctcc aagagcccat ttgaagtgag tgttgacaag gcccagggag    780

atgccagtaa agtcactgca aaaggtccag ggttggaagc tgtagggaac atcgccaata    840

agcccaccta ctttgacatc tatacggcag gagctggtgt gggtgacatt ggtgtggagg    900

tggaagatcc ccaggggaag aacaccgtgg agttgctcgt ggaagacaaa ggaaaccagg    960

tgtatcgatg tgtgtacaaa cccatgcagc ctggccctca cgtggtcaag atcttctttg   1020

ctggggacac tattcctaag agtcccttcg ttgtgcaggt tggggaagcc tgcaatccaa   1080

atgcctgccg ggccagtggc cgaggcctac aacccaaagg cgtccgtatc cgggagacca   1140

cagatttcaa ggttgacacc aaagctgcag gaagtgggga gctcggtgta accatgaagg   1200

gtcctaaggg tctggaggag ctggtgaagc agaaagactt tctggatggg gtctacgcat   1260

tcgagtatta ccccagcacc ccggggagat acagcattgc catcacatgg gggggacacc   1320

acattccaaa gagccccttt gaagttcaag ttggccctga agcgggtatg cagaaagtcc   1380

gtgcttgggg ccctgggctc catggtggga ttgtcgggcg gtcagcggac ttcgtggtag   1440

aatccattgg ctctgaagtg gggtctctgg ggtttgccat tgaaggcccc tctcaggcaa   1500

agattgagta caacgaccag aatgatggat cgtgtgatgt caaatactgg cccaaggagc   1560

ctggcgaata tgctgttcac atcatgtgtg acgacgaaga catcaaggac agcccgtaca   1620

tggccttcat ccacccagcc acgggaggct acaaccctga tctggttcga gcatacgggc   1680

caggtttgga gaaatctgga tgcattgtca acaacctggc cgagttcact gtggatccta   1740

aggatgctgg aaaagctccc ttaaagatat ttgctcagga tggggaaggc caacgcattg   1800

acatccagat gaagaaccgg atggacggca catatgcatg ctcatacacc ccggtgaagg   1860

ccatcaagca caccattgct gtggtctggg gaggcgtgaa catcccgcac agcccctaca   1920

gggtcaacat cgggcaaggt agccatcctc agaaggtcaa agtgtttggg ccaggtgtgg   1980

agagaagtgg tctgaaggca aatgaaccta cacacttcac ggtggactgt actgaggctg   2040

gggaaggtga tgtcagtgtt ggcattaagt gtgatgcccg ggtgttaagt gaagatgagg   2100

aagacgtgga ttttgacatt attcacaatg ccaatgatac gttcacagtc aaatatgtgc   2160

ctcctgctgc tgggcgatac actatcaaag ttctctttgc atctcaggaa atccccgcca   2220

gccctttcag agtcaaagtt gacccttccc acgatgccag caaagtgaag gcagaaggcc   2280

cagggctcag caaagcaggt gtggaaaatg ggaaaccgac ccacttcact gtctacacca   2340

agggggctgg gaaagccccg ctcaacgtgc agttcaacag ccctcttcct ggcgatgcag   2400

tgaaggattt ggatatcatc gataattatg actactctca cacggttaaa tatacaccca   2460

cccaacaggg caacatgcag gttctggtga cttacggtgg cgatcccatc cctaaaagcc   2520

ctttcactgt gggtgttgct gcaccgctgg atctgagcaa gataaaactc aatgggctgg   2580

aaaacagggt ggaagttggg aaggatcagg agttcaccgt tgataccagg ggggcaggag   2640

gccaggggaa gctggacgtg acaatcctca gcccctctcg gaaggtcgtg ccatgcctag   2700

tgacacctgt gacaggccgg gagaacagca cggccaagtt catccctcgg gaggaggggc   2760

tgtatgctgt agacgtgacc tacgatggac accctgtgcc cgggagcccc tacacagtgg   2820

aggcctcgct gccaccagat cccagcaagg tgaaggccca cggtcccggc ctcgaaggtg   2880

gtctcgtggg caagcctgcc gagttcacca tcgataccaa aggagctggt actggaggtc   2940

tgggcttaac ggtggaaggt ccgtgcgagg ccaaaatcga gtgctccgac aatggtgatg   3000

ggacctgctc cgtctcttac cttcccacaa aacccgggga gtacttcgtc aacatcctct   3060

ttgaagaagt ccacatacct gggtctccct tcaaagctga cattgaaatg ccctttgacc   3120

cctctaaagt cgtggcatcg gggccaggtc tcgagcacgg gaaggtgggt gaagctggcc   3180

tccttagcgt cgactgctcg gaagcgggac cgggggccct gggcctggaa gctgtctcgg   3240

actcgggaac aaaagccgaa gtcagtattc agaacaacaa agatggcacc tacgcggtga   3300

cctacgtgcc cctgacggcc ggcatgtaca cgttgaccat gaagtatggt ggcgaactcg   3360

tgccacactt ccccgcccgg gtcaaggtgg agcccgccgt ggacaccagc aggatcaaag   3420

tctttggacc aggaatagaa gggaaagatg tgttccggga agctaccacc gactttacag   3480

ttgactctcg gccgctgacc caggttgggg gtgaccacat caaggcccac attgccaacc   3540

cctcaggggc ctccaccgag tgctttgtca cagacaatgc ggatgggacc taccaggtgg   3600

aatacacacc ctttgagaaa ggtctccatg tagtggaggt gacatatgat gacgtgccta   3660

tcccaaacag tcccttcaag gtggctgtca ctgaaggctg ccagccatct agggtgcaag   3720

cccaaggacc tggattgaaa gaggccttta ccaacaagcc caatgtcttc accgtggtta   3780

ccagaggcgc aggaattggt gggcttggca taactgttga gggaccatca gagtcgaaga   3840

taaattgcag agacaacaag gatggcagct gcagtgctga gtacattcct ttcgcaccgg   3900

gggattacga tgttaatatc acatatggag gagcccacat ccccggcagc cccttcaggg   3960

ttcctgtgaa ggatgttgtg gaccccagca aggtcaagat tgccggcccc gggctgggct   4020

caggcgtccg agcccgtgtc ctgcagtcct tcacggtgga cagcagcaag gctggcctgg   4080

ctccgctgga agtgagggtt ctgggcccac gaggcttggt ggagccagtg aacgtggtgg   4140

acaatggaga tggcacacac acagtaacct acaccccatc tcaggaggga ccttacatgg   4200

tctcagttaa atatgctgat gaagagattc ctcgcagtcc cttcaaggtc aaggtccttc   4260

ccacatatga tgccagcaaa gtgactgcca gtggccccgg ccttagttcc tatggtgtgc   4320

ctgccagtct acctgtggac tttgcaattg atgcccgaga tgccggggaa ggcctgcttg   4380

ctgttcaaat aacggaccaa gaaggaaaac ccaaaagagc cattgtccat gacaataaag   4440

atggcacgta tgctgtcacc tacatccccg acaagactgg gcgctatatg attggagtca   4500

cctacggggg tgacgacatc ccactttctc cttatcgcat ccgagccaca cagacgggtg   4560

atgccagcaa gtgcctggcc acgggtcctg gaatcgcctc cactgtgaaa actggcgaag   4620

aagtaggctt tgtggttgat gccaagactg ccgggaaggg taaagtgacc tgcacggttc   4680

tgaccccaga tggcactgag gccgaggccg atgtcattga gaatgaagat ggaacctatg   4740

acatcttcta cacagctgcc aagccgggca catatgtgat ctatgtgcgc ttcggtggtg   4800

ttgatattcc taacagcccc ttcactgtca tggccacaga tggggaagtc acagccgtgg   4860

aggaggcacc ggtgaccgaa gaggcctatg tcccagtgag tgacatgaac ggcctgggat   4920

ttaagccttt tgacctggtc attccgtttg ctgtcaggaa aggagaaatc actggagagg   4980

tccacatgcc ttctgggaag acagccacac ctgagattgt ggacaacaag gacggcacgg   5040

tcactgttag atatgccccc actgaggtcg ggctccatga gatgcacatc aaatacatgg   5100

gcagccacat ccctgagagc ccactccagt tctacgtgaa ctaccccaac agtggaagtg   5160

tttctgcata cggtccaggc ctcgtgtatg gagtggccaa caaaactgcc accttcacca   5220

tcgtcacaga ggatgcagga gaaggtggtc tggacttggc tattgagggc ccctcaaaag   5280

cagaaatcag ctgcattgac aataaagatg ggacatgcac agtgacctac ctgccgactc   5340

tgccaggcga ctacagcatt ctggtcaagt acaatgacaa gcacatccct ggcagcccct   5400

tcacagccaa gatcacagat gacagcaggc ggtgctccca ggtgaagttg ggctcagccg   5460

ctgacttcct gctcgacatc agtgagactg acctcagcag cctgacggcc agcattaagg   5520

ccccatctgg ccgagacgag ccctgtctcc tgaagaggct gcccaacaac cacattggca   5580

tctccttcat cccccgggaa gtgggcgaac atctggtcag catcaagaaa aatggcaacc   5640

atgtggccaa cagccccgtg tctatcatgg tggtccagtc ggagattggt gacgcccgcc   5700

gagccaaagt ctatggccgc ggcctgtcag aaggccggac tttcgagatg tctgacttca   5760

tcgtggacac aagggatgca ggttatggtg gcatatcctt ggcggtggaa ggccccagca   5820

aagtggacat ccagacggag gacctggaag atggcacctg caaagtctcc tacttcccta   5880

ccgtgcctgg ggtttatatc gtctccacca aattcgctga cgagcacgtg cctgggagcc   5940

catttaccgt gaagatcagt ggggagggaa gagtcaaaga gagcatcacc cgcaccagtc   6000

gggccccgtc cgtggccact gtcgggagca tttgtgacct gaacctgaaa atcccagaaa   6060

tcaacagcag tgatatgtcg gcccacgtca ccagcccctc tggccgtgtg actgaggcag   6120

agattgtgcc catggggaag aactcacact gcgtccggtt tgtgccccag gagatgggcg   6180

tgcacacggt cagcgtcaag taccgtgggc agcacgtcac cggcagcccc ttccagttca   6240

ccgtggggcc acttggtgaa ggaggcgccc acaaggtgcg ggcaggaggc cctggcctgg   6300

agagaggaga agcgggagtc ccagctgagt tcagcatttg gacccgggaa gcaggcgctg   6360

gaggcctctc catcgctgtt gagggcccca gtaaggccga gattacattc gatgaccata   6420

aaaatgggtc gtgcggtgta tcttatattg cccaagagcc tggtaactac gaggtgtcca   6480

tcaagttcaa tgatgagcac atcccggaaa gcccctacct ggtgccggtc atcgcaccct   6540

ccgacgacgc ccgccgcctc actgttatga gccttcagga atcgggatta aaagttaacc   6600

agccagcatc ctttgctata aggttgaatg gcgcaaaagg caagattgat gcaaaggtgc   6660

acagcccctc tggagccgtg gaggagtgcc acgtgtctga gctggagcca gataagtatg   6720

ctgttcgctt catccctcat gagaatggtg tccacaccat cgatgtcaag ttcaatggga   6780

gccacgtggt tggaagcccc ttcaaagtgc gcgttgggga gcctggacaa gcggggaacc   6840

ctgccctggt gtccgcctat ggcacgggac tcgaaggggg caccacaggt atccagtcgg   6900

aattctttat taacaccacc cgagcaggtc cagggacatt atccgtcacc atcgaaggcc   6960

catccaaggt taaaatggat tgccaggaaa cacctgaagg gtacaaagtc atgtacaccc   7020

ccatggctcc tggtaactac ctgatcagcg tcaaatacgg tgggcccaac cacatcgtgg   7080

gcagtccctt caaggccaag gtgacaggcc agcgtctagt tagccctggc tcagccaacg   7140

agacctcatc catcctggtg gagtcagtga ccaggtcgtc tacagagacc tgctatagcg   7200

ccattcccaa ggcatcctcg gacgccagca aggtgacctc taagggggca gggctctcaa   7260

aggcctttgt gggccagaag agttccttcc tggtggactg cagcaaagct ggctccaaca   7320

tgctgctgat cggggtccat gggcccacca ccccctgcga ggaggtctcc atgaagcatg   7380

taggcaacca gcaatacaac gtcacatacg tcgtcaagga gaggggcgat tatgtgctgg   7440

ctgtgaagtg gggggaggaa cacatccctg gcagcccttt tcatgtcaca gtgccttaaa   7500

acagttttct caaatcctgg agagagttct tgtggttgct tttgttgctt gtttgtaatt   7560

cattttatac aaagccctcc agcctgtttg tggggctgaa accccatccc taaaatattg   7620

ctgttgtaaa atgccttcag aaataagtcc tagactggac tcttgaggga catattggag   7680

aatcttaaga aatgcaagct tgttcagggg gctgagaaga tcctgagtac actaggtgca   7740

aaccagaact cttggtggaa cagaccagcc actgcagcag acagaccagg aacacaatga   7800

gactgacatt tcaaaaaaac aaaactggct agcctgagct gctggttcac tcttcagcat   7860

ttatgaaaca aggctagggg aagatgggca gagaaaaagg ggacacctag tttggttgtc   7920

atttggcaaa ggagatgact taaaatccgc ttaatctctt ccagtgtccg tgttaatgta   7980

tttggctatt agatcactag cactgcttta ccgctcctca tcgccaacac ccccatgctc   8040

tgtggccttc ttacacttct cagagggcag agtggcagcc gggcacccta cagaaactca   8100

gagggcagag tggcagccag gcccacatgt ctctcaagta cctgtcccct cgctctggtg   8160

attatttctt gcagaatcac cacacgagac ca                                 8192


<210>  9439
<211>  2422
<212>  PRT
<213>  Homosapiens

<400>  9439

Met Gln Glu His Ser Thr Arg Arg Arg Ser Leu Ser Leu Cys Pro Asp 
1               5                   10                  15      


Trp Glu Ser Trp Asp Pro Gln Lys Pro Val Asp Asn Ala Arg Glu Ala 
            20                  25                  30          


Met Gln Gln Ala Asp Asp Trp Leu Gly Val Pro Gln Val Ile Thr Pro 
        35                  40                  45              


Glu Glu Ile Ile His Pro Asp Val Asp Glu His Ser Val Met Thr Tyr 
    50                  55                  60                  


Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly Ala Pro Leu Lys 
65                  70                  75                  80  


Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly Arg Gly Ile Glu 
                85                  90                  95      


Pro Thr Gly Asn Met Val Lys Gln Pro Ala Lys Phe Thr Val Asp Thr 
            100                 105                 110         


Ile Ser Ala Gly Gln Gly Asp Val Met Val Phe Val Glu Asp Pro Glu 
        115                 120                 125             


Gly Asn Lys Glu Glu Ala Gln Val Thr Pro Asp Ser Asp Lys Asn Lys 
    130                 135                 140                 


Thr Tyr Ser Val Glu Tyr Leu Pro Lys Val Thr Gly Leu His Lys Val 
145                 150                 155                 160 


Thr Val Leu Phe Ala Gly Gln His Ile Ser Lys Ser Pro Phe Glu Val 
                165                 170                 175     


Ser Val Asp Lys Ala Gln Gly Asp Ala Ser Lys Val Thr Ala Lys Gly 
            180                 185                 190         


Pro Gly Leu Glu Ala Val Gly Asn Ile Ala Asn Lys Pro Thr Tyr Phe 
        195                 200                 205             


Asp Ile Tyr Thr Ala Gly Ala Gly Val Gly Asp Ile Gly Val Glu Val 
    210                 215                 220                 


Glu Asp Pro Gln Gly Lys Asn Thr Val Glu Leu Leu Val Glu Asp Lys 
225                 230                 235                 240 


Gly Asn Gln Val Tyr Arg Cys Val Tyr Lys Pro Met Gln Pro Gly Pro 
                245                 250                 255     


His Val Val Lys Ile Phe Phe Ala Gly Asp Thr Ile Pro Lys Ser Pro 
            260                 265                 270         


Phe Val Val Gln Val Gly Glu Ala Cys Asn Pro Asn Ala Cys Arg Ala 
        275                 280                 285             


Ser Gly Arg Gly Leu Gln Pro Lys Gly Val Arg Ile Arg Glu Thr Thr 
    290                 295                 300                 


Asp Phe Lys Val Asp Thr Lys Ala Ala Gly Ser Gly Glu Leu Gly Val 
305                 310                 315                 320 


Thr Met Lys Gly Pro Lys Gly Leu Glu Glu Leu Val Lys Gln Lys Asp 
                325                 330                 335     


Phe Leu Asp Gly Val Tyr Ala Phe Glu Tyr Tyr Pro Ser Thr Pro Gly 
            340                 345                 350         


Arg Tyr Ser Ile Ala Ile Thr Trp Gly Gly His His Ile Pro Lys Ser 
        355                 360                 365             


Pro Phe Glu Val Gln Val Gly Pro Glu Ala Gly Met Gln Lys Val Arg 
    370                 375                 380                 


Ala Trp Gly Pro Gly Leu His Gly Gly Ile Val Gly Arg Ser Ala Asp 
385                 390                 395                 400 


Phe Val Val Glu Ser Ile Gly Ser Glu Val Gly Ser Leu Gly Phe Ala 
                405                 410                 415     


Ile Glu Gly Pro Ser Gln Ala Lys Ile Glu Tyr Asn Asp Gln Asn Asp 
            420                 425                 430         


Gly Ser Cys Asp Val Lys Tyr Trp Pro Lys Glu Pro Gly Glu Tyr Ala 
        435                 440                 445             


Val His Ile Met Cys Asp Asp Glu Asp Ile Lys Asp Ser Pro Tyr Met 
    450                 455                 460                 


Ala Phe Ile His Pro Ala Thr Gly Gly Tyr Asn Pro Asp Leu Val Arg 
465                 470                 475                 480 


Ala Tyr Gly Pro Gly Leu Glu Lys Ser Gly Cys Ile Val Asn Asn Leu 
                485                 490                 495     


Ala Glu Phe Thr Val Asp Pro Lys Asp Ala Gly Lys Ala Pro Leu Lys 
            500                 505                 510         


Ile Phe Ala Gln Asp Gly Glu Gly Gln Arg Ile Asp Ile Gln Met Lys 
        515                 520                 525             


Asn Arg Met Asp Gly Thr Tyr Ala Cys Ser Tyr Thr Pro Val Lys Ala 
    530                 535                 540                 


Ile Lys His Thr Ile Ala Val Val Trp Gly Gly Val Asn Ile Pro His 
545                 550                 555                 560 


Ser Pro Tyr Arg Val Asn Ile Gly Gln Gly Ser His Pro Gln Lys Val 
                565                 570                 575     


Lys Val Phe Gly Pro Gly Val Glu Arg Ser Gly Leu Lys Ala Asn Glu 
            580                 585                 590         


Pro Thr His Phe Thr Val Asp Cys Thr Glu Ala Gly Glu Gly Asp Val 
        595                 600                 605             


Ser Val Gly Ile Lys Cys Asp Ala Arg Val Leu Ser Glu Asp Glu Glu 
    610                 615                 620                 


Asp Val Asp Phe Asp Ile Ile His Asn Ala Asn Asp Thr Phe Thr Val 
625                 630                 635                 640 


Lys Tyr Val Pro Pro Ala Ala Gly Arg Tyr Thr Ile Lys Val Leu Phe 
                645                 650                 655     


Ala Ser Gln Glu Ile Pro Ala Ser Pro Phe Arg Val Lys Val Asp Pro 
            660                 665                 670         


Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro Gly Leu Ser Lys 
        675                 680                 685             


Ala Gly Val Glu Asn Gly Lys Pro Thr His Phe Thr Val Tyr Thr Lys 
    690                 695                 700                 


Gly Ala Gly Lys Ala Pro Leu Asn Val Gln Phe Asn Ser Pro Leu Pro 
705                 710                 715                 720 


Gly Asp Ala Val Lys Asp Leu Asp Ile Ile Asp Asn Tyr Asp Tyr Ser 
                725                 730                 735     


His Thr Val Lys Tyr Thr Pro Thr Gln Gln Gly Asn Met Gln Val Leu 
            740                 745                 750         


Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro Phe Thr Val Gly 
        755                 760                 765             


Val Ala Ala Pro Leu Asp Leu Ser Lys Ile Lys Leu Asn Gly Leu Glu 
    770                 775                 780                 


Asn Arg Val Glu Val Gly Lys Asp Gln Glu Phe Thr Val Asp Thr Arg 
785                 790                 795                 800 


Gly Ala Gly Gly Gln Gly Lys Leu Asp Val Thr Ile Leu Ser Pro Ser 
                805                 810                 815     


Arg Lys Val Val Pro Cys Leu Val Thr Pro Val Thr Gly Arg Glu Asn 
            820                 825                 830         


Ser Thr Ala Lys Phe Ile Pro Arg Glu Glu Gly Leu Tyr Ala Val Asp 
        835                 840                 845             


Val Thr Tyr Asp Gly His Pro Val Pro Gly Ser Pro Tyr Thr Val Glu 
    850                 855                 860                 


Ala Ser Leu Pro Pro Asp Pro Ser Lys Val Lys Ala His Gly Pro Gly 
865                 870                 875                 880 


Leu Glu Gly Gly Leu Val Gly Lys Pro Ala Glu Phe Thr Ile Asp Thr 
                885                 890                 895     


Lys Gly Ala Gly Thr Gly Gly Leu Gly Leu Thr Val Glu Gly Pro Cys 
            900                 905                 910         


Glu Ala Lys Ile Glu Cys Ser Asp Asn Gly Asp Gly Thr Cys Ser Val 
        915                 920                 925             


Ser Tyr Leu Pro Thr Lys Pro Gly Glu Tyr Phe Val Asn Ile Leu Phe 
    930                 935                 940                 


Glu Glu Val His Ile Pro Gly Ser Pro Phe Lys Ala Asp Ile Glu Met 
945                 950                 955                 960 


Pro Phe Asp Pro Ser Lys Val Val Ala Ser Gly Pro Gly Leu Glu His 
                965                 970                 975     


Gly Lys Val Gly Glu Ala Gly Leu Leu Ser Val Asp Cys Ser Glu Ala 
            980                 985                 990         


Gly Pro Gly Ala Leu Gly Leu Glu  Ala Val Ser Asp Ser  Gly Thr Lys 
        995                 1000                 1005             


Ala Glu  Val Ser Ile Gln Asn  Asn Lys Asp Gly Thr  Tyr Ala Val 
    1010                 1015                 1020             


Thr Tyr  Val Pro Leu Thr Ala  Gly Met Tyr Thr Leu  Thr Met Lys 
    1025                 1030                 1035             


Tyr Gly  Gly Glu Leu Val Pro  His Phe Pro Ala Arg  Val Lys Val 
    1040                 1045                 1050             


Glu Pro  Ala Val Asp Thr Ser  Arg Ile Lys Val Phe  Gly Pro Gly 
    1055                 1060                 1065             


Ile Glu  Gly Lys Asp Val Phe  Arg Glu Ala Thr Thr  Asp Phe Thr 
    1070                 1075                 1080             


Val Asp  Ser Arg Pro Leu Thr  Gln Val Gly Gly Asp  His Ile Lys 
    1085                 1090                 1095             


Ala His  Ile Ala Asn Pro Ser  Gly Ala Ser Thr Glu  Cys Phe Val 
    1100                 1105                 1110             


Thr Asp  Asn Ala Asp Gly Thr  Tyr Gln Val Glu Tyr  Thr Pro Phe 
    1115                 1120                 1125             


Glu Lys  Gly Leu His Val Val  Glu Val Thr Tyr Asp  Asp Val Pro 
    1130                 1135                 1140             


Ile Pro  Asn Ser Pro Phe Lys  Val Ala Val Thr Glu  Gly Cys Gln 
    1145                 1150                 1155             


Pro Ser  Arg Val Gln Ala Gln  Gly Pro Gly Leu Lys  Glu Ala Phe 
    1160                 1165                 1170             


Thr Asn  Lys Pro Asn Val Phe  Thr Val Val Thr Arg  Gly Ala Gly 
    1175                 1180                 1185             


Ile Gly  Gly Leu Gly Ile Thr  Val Glu Gly Pro Ser  Glu Ser Lys 
    1190                 1195                 1200             


Ile Asn  Cys Arg Asp Asn Lys  Asp Gly Ser Cys Ser  Ala Glu Tyr 
    1205                 1210                 1215             


Ile Pro  Phe Ala Pro Gly Asp  Tyr Asp Val Asn Ile  Thr Tyr Gly 
    1220                 1225                 1230             


Gly Ala  His Ile Pro Gly Ser  Pro Phe Arg Val Pro  Val Lys Asp 
    1235                 1240                 1245             


Val Val  Asp Pro Ser Lys Val  Lys Ile Ala Gly Pro  Gly Leu Gly 
    1250                 1255                 1260             


Ser Gly  Val Arg Ala Arg Val  Leu Gln Ser Phe Thr  Val Asp Ser 
    1265                 1270                 1275             


Ser Lys  Ala Gly Leu Ala Pro  Leu Glu Val Arg Val  Leu Gly Pro 
    1280                 1285                 1290             


Arg Gly  Leu Val Glu Pro Val  Asn Val Val Asp Asn  Gly Asp Gly 
    1295                 1300                 1305             


Thr His  Thr Val Thr Tyr Thr  Pro Ser Gln Glu Gly  Pro Tyr Met 
    1310                 1315                 1320             


Val Ser  Val Lys Tyr Ala Asp  Glu Glu Ile Pro Arg  Ser Pro Phe 
    1325                 1330                 1335             


Lys Val  Lys Val Leu Pro Thr  Tyr Asp Ala Ser Lys  Val Thr Ala 
    1340                 1345                 1350             


Ser Gly  Pro Gly Leu Ser Ser  Tyr Gly Val Pro Ala  Ser Leu Pro 
    1355                 1360                 1365             


Val Asp  Phe Ala Ile Asp Ala  Arg Asp Ala Gly Glu  Gly Leu Leu 
    1370                 1375                 1380             


Ala Val  Gln Ile Thr Asp Gln  Glu Gly Lys Pro Lys  Arg Ala Ile 
    1385                 1390                 1395             


Val His  Asp Asn Lys Asp Gly  Thr Tyr Ala Val Thr  Tyr Ile Pro 
    1400                 1405                 1410             


Asp Lys  Thr Gly Arg Tyr Met  Ile Gly Val Thr Tyr  Gly Gly Asp 
    1415                 1420                 1425             


Asp Ile  Pro Leu Ser Pro Tyr  Arg Ile Arg Ala Thr  Gln Thr Gly 
    1430                 1435                 1440             


Asp Ala  Ser Lys Cys Leu Ala  Thr Gly Pro Gly Ile  Ala Ser Thr 
    1445                 1450                 1455             


Val Lys  Thr Gly Glu Glu Val  Gly Phe Val Val Asp  Ala Lys Thr 
    1460                 1465                 1470             


Ala Gly  Lys Gly Lys Val Thr  Cys Thr Val Leu Thr  Pro Asp Gly 
    1475                 1480                 1485             


Thr Glu  Ala Glu Ala Asp Val  Ile Glu Asn Glu Asp  Gly Thr Tyr 
    1490                 1495                 1500             


Asp Ile  Phe Tyr Thr Ala Ala  Lys Pro Gly Thr Tyr  Val Ile Tyr 
    1505                 1510                 1515             


Val Arg  Phe Gly Gly Val Asp  Ile Pro Asn Ser Pro  Phe Thr Val 
    1520                 1525                 1530             


Met Ala  Thr Asp Gly Glu Val  Thr Ala Val Glu Glu  Ala Pro Val 
    1535                 1540                 1545             


Thr Glu  Glu Ala Tyr Val Pro  Val Ser Asp Met Asn  Gly Leu Gly 
    1550                 1555                 1560             


Phe Lys  Pro Phe Asp Leu Val  Ile Pro Phe Ala Val  Arg Lys Gly 
    1565                 1570                 1575             


Glu Ile  Thr Gly Glu Val His  Met Pro Ser Gly Lys  Thr Ala Thr 
    1580                 1585                 1590             


Pro Glu  Ile Val Asp Asn Lys  Asp Gly Thr Val Thr  Val Arg Tyr 
    1595                 1600                 1605             


Ala Pro  Thr Glu Val Gly Leu  His Glu Met His Ile  Lys Tyr Met 
    1610                 1615                 1620             


Gly Ser  His Ile Pro Glu Ser  Pro Leu Gln Phe Tyr  Val Asn Tyr 
    1625                 1630                 1635             


Pro Asn  Ser Gly Ser Val Ser  Ala Tyr Gly Pro Gly  Leu Val Tyr 
    1640                 1645                 1650             


Gly Val  Ala Asn Lys Thr Ala  Thr Phe Thr Ile Val  Thr Glu Asp 
    1655                 1660                 1665             


Ala Gly  Glu Gly Gly Leu Asp  Leu Ala Ile Glu Gly  Pro Ser Lys 
    1670                 1675                 1680             


Ala Glu  Ile Ser Cys Ile Asp  Asn Lys Asp Gly Thr  Cys Thr Val 
    1685                 1690                 1695             


Thr Tyr  Leu Pro Thr Leu Pro  Gly Asp Tyr Ser Ile  Leu Val Lys 
    1700                 1705                 1710             


Tyr Asn  Asp Lys His Ile Pro  Gly Ser Pro Phe Thr  Ala Lys Ile 
    1715                 1720                 1725             


Thr Asp  Asp Ser Arg Arg Cys  Ser Gln Val Lys Leu  Gly Ser Ala 
    1730                 1735                 1740             


Ala Asp  Phe Leu Leu Asp Ile  Ser Glu Thr Asp Leu  Ser Ser Leu 
    1745                 1750                 1755             


Thr Ala  Ser Ile Lys Ala Pro  Ser Gly Arg Asp Glu  Pro Cys Leu 
    1760                 1765                 1770             


Leu Lys  Arg Leu Pro Asn Asn  His Ile Gly Ile Ser  Phe Ile Pro 
    1775                 1780                 1785             


Arg Glu  Val Gly Glu His Leu  Val Ser Ile Lys Lys  Asn Gly Asn 
    1790                 1795                 1800             


His Val  Ala Asn Ser Pro Val  Ser Ile Met Val Val  Gln Ser Glu 
    1805                 1810                 1815             


Ile Gly  Asp Ala Arg Arg Ala  Lys Val Tyr Gly Arg  Gly Leu Ser 
    1820                 1825                 1830             


Glu Gly  Arg Thr Phe Glu Met  Ser Asp Phe Ile Val  Asp Thr Arg 
    1835                 1840                 1845             


Asp Ala  Gly Tyr Gly Gly Ile  Ser Leu Ala Val Glu  Gly Pro Ser 
    1850                 1855                 1860             


Lys Val  Asp Ile Gln Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Lys 
    1865                 1870                 1875             


Val Ser  Tyr Phe Pro Thr Val  Pro Gly Val Tyr Ile  Val Ser Thr 
    1880                 1885                 1890             


Lys Phe  Ala Asp Glu His Val  Pro Gly Ser Pro Phe  Thr Val Lys 
    1895                 1900                 1905             


Ile Ser  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Thr Ser 
    1910                 1915                 1920             


Arg Ala  Pro Ser Val Ala Thr  Val Gly Ser Ile Cys  Asp Leu Asn 
    1925                 1930                 1935             


Leu Lys  Ile Pro Glu Ile Asn  Ser Ser Asp Met Ser  Ala His Val 
    1940                 1945                 1950             


Thr Ser  Pro Ser Gly Arg Val  Thr Glu Ala Glu Ile  Val Pro Met 
    1955                 1960                 1965             


Gly Lys  Asn Ser His Cys Val  Arg Phe Val Pro Gln  Glu Met Gly 
    1970                 1975                 1980             


Val His  Thr Val Ser Val Lys  Tyr Arg Gly Gln His  Val Thr Gly 
    1985                 1990                 1995             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2000                 2005                 2010             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Gly Glu Ala 
    2015                 2020                 2025             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2030                 2035                 2040             


Gly Gly  Leu Ser Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2045                 2050                 2055             


Thr Phe  Asp Asp His Lys Asn  Gly Ser Cys Gly Val  Ser Tyr Ile 
    2060                 2065                 2070             


Ala Gln  Glu Pro Gly Asn Tyr  Glu Val Ser Ile Lys  Phe Asn Asp 
    2075                 2080                 2085             


Glu His  Ile Pro Glu Ser Pro  Tyr Leu Val Pro Val  Ile Ala Pro 
    2090                 2095                 2100             


Ser Asp  Asp Ala Arg Arg Leu  Thr Val Met Ser Leu  Gln Glu Ser 
    2105                 2110                 2115             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Ile  Arg Leu Asn 
    2120                 2125                 2130             


Gly Ala  Lys Gly Lys Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2135                 2140                 2145             


Ala Val  Glu Glu Cys His Val  Ser Glu Leu Glu Pro  Asp Lys Tyr 
    2150                 2155                 2160             


Ala Val  Arg Phe Ile Pro His  Glu Asn Gly Val His  Thr Ile Asp 
    2165                 2170                 2175             


Val Lys  Phe Asn Gly Ser His  Val Val Gly Ser Pro  Phe Lys Val 
    2180                 2185                 2190             


Arg Val  Gly Glu Pro Gly Gln  Ala Gly Asn Pro Ala  Leu Val Ser 
    2195                 2200                 2205             


Ala Tyr  Gly Thr Gly Leu Glu  Gly Gly Thr Thr Gly  Ile Gln Ser 
    2210                 2215                 2220             


Glu Phe  Phe Ile Asn Thr Thr  Arg Ala Gly Pro Gly  Thr Leu Ser 
    2225                 2230                 2235             


Val Thr  Ile Glu Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2240                 2245                 2250             


Thr Pro  Glu Gly Tyr Lys Val  Met Tyr Thr Pro Met  Ala Pro Gly 
    2255                 2260                 2265             


Asn Tyr  Leu Ile Ser Val Lys  Tyr Gly Gly Pro Asn  His Ile Val 
    2270                 2275                 2280             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Gln Arg  Leu Val Ser 
    2285                 2290                 2295             


Pro Gly  Ser Ala Asn Glu Thr  Ser Ser Ile Leu Val  Glu Ser Val 
    2300                 2305                 2310             


Thr Arg  Ser Ser Thr Glu Thr  Cys Tyr Ser Ala Ile  Pro Lys Ala 
    2315                 2320                 2325             


Ser Ser  Asp Ala Ser Lys Val  Thr Ser Lys Gly Ala  Gly Leu Ser 
    2330                 2335                 2340             


Lys Ala  Phe Val Gly Gln Lys  Ser Ser Phe Leu Val  Asp Cys Ser 
    2345                 2350                 2355             


Lys Ala  Gly Ser Asn Met Leu  Leu Ile Gly Val His  Gly Pro Thr 
    2360                 2365                 2370             


Thr Pro  Cys Glu Glu Val Ser  Met Lys His Val Gly  Asn Gln Gln 
    2375                 2380                 2385             


Tyr Asn  Val Thr Tyr Val Val  Lys Glu Arg Gly Asp  Tyr Val Leu 
    2390                 2395                 2400             


Ala Val  Lys Trp Gly Glu Glu  His Ile Pro Gly Ser  Pro Phe His 
    2405                 2410                 2415             


Val Thr  Val Pro 
    2420         


<210>  9440
<211>  478
<212>  DNA
<213>  Homosapiens

<400>  9440
atcatttagg tgggagagag gatgttagta aattaaaaga aaaaggttat tcattaaatg     60

ctaaatagta taggatgtac aggccagaaa agaaaaagga agtccacgag tgaggaaagg    120

ttggaaaaca atagtagaat taggaaagct attcaaaatg ctctcttatg taaaaaagag    180

ctttgcttag gaatatgtta gaattttttt tgcctgtttt ttgactaaga cttgagagtt    240

ctttctacat gttctagata ctagtgttct gttggacata tggtttgcaa attttttctc    300

ccagtcttta gcctgtatat tcatcctctt aactgtaaaa agttttaaat tgtttgtaaa    360

agtaaaatcc agcccccaga tcccagtctc agcaacattt tgagttctgt ttgagacggt    420

gtccgggtgg cttttatagt gtgagggcta agacagcttg tcttgcagga cagtaggt      478


<210>  9441
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  9441

Met Leu Asn Ser Ile Gly Cys Thr Gly Gln Lys Arg Lys Arg Lys Ser 
1               5                   10                  15      


Thr Ser Glu Glu Arg Leu Glu Asn Asn Ser Arg Ile Arg Lys Ala Ile 
            20                  25                  30          


Gln Asn Ala Leu Leu Cys Lys Lys Glu Leu Cys Leu Gly Ile Cys 
        35                  40                  45          


<210>  9442
<211>  6889
<212>  DNA
<213>  Homosapiens

<400>  9442
gcaggaggtt ttatcttttg aagctcaggg cagaaatggt ttgggggaaa ttaggtcatg     60

ggtctgggat cagattctgt gaagttactg agcttcagga cctgcatgtg tttgtgtgca    120

tgtatgtgtc cctgtgtatg tgtgaatgag agagggagaa aaagaagaaa gagaagcttt    180

acttggatat ctgcctctat tatgaaggac tctcaagtaa cagccttttg attttagctg    240

acgacacgga ttcccagtca tggcgcagcc ccttgaaagc cctttcagag ttctttaaag    300

gtgacccgaa gggtgacttt aataagacag gtttgcattt tcccatggct gctgaattat    360

gtaacccaaa tgcttcttgc tggcctcact tctaaaattg cttacacctg cctcatctgc    420

tttgcttaat gagcatgcca tcctttgatt aacctaccct ggagttgacc catccttgac    480

tgtcacgttg gaagctggga tctggactct gcaacccaac gcgtgccttg attatgtttt    540

agcataatct ctaacatctc cacaggcttc accttgaggg tccccttgcc ccatgagatt    600

ggcaccctca cctgccctgc acctatgccc cagcatgctg gtaccacagt gttctttgct    660

caaaggtggc cacaagtctt gactagccag cccattggtt aatttttgct cttcacaatt    720

ctggactctt tggcagtgtc tcagctgtag agtaaaattg ccacatccta agcgtgccta    780

accagcttga aaggttatat tgtgtcttca acacacatca tccacataca ccctccagca    840

gcaagcacag gcagtctcct taattatact ctagggcaga ctgagtgtat tttagccaac    900

aaaaagctaa aggtgtctct cggggtcatt tctgcaacca tgaattgggg atcctgtgat    960

ttttttcagg cctgtgatta tggttgctgg cctttttgtt actcatcagt ggaaaccaat   1020

agctcttggg gatggatgtg gtcctatttc agactcagcc aagggtggag taaaggtgag   1080

gccaggcagc tccttaaacc tctcatctct gtcctcaggc ttggtggagc cagtgaacgt   1140

ggtggacaat ggagatggca cacacacagt aacctacacc ccatctcagg agggacctta   1200

catggtctca gttaaatatg ctgatgaaga gattcctcgc agtcccttca aggtcaaggt   1260

ccttcccaca tatgatgcca gcaaagtgac tgccagtggc cccggcctta gttcctatgg   1320

tgtgcctgcc agtctacctg tggactttgc aattgatgcc cgagatgccg gggaaggcct   1380

gcttgctgtt caaataacgg accaagaagg aaaacccaaa agagccattg tccatgacaa   1440

taaagatggc acgtatgctg tcacctacat ccccgacaag actgggcgct atatgattgg   1500

agtcacctac gggggtgacg acatcccact ttctccttat cgcatccgag ccacacagac   1560

gggtgatgcc agcaagtgcc tggccacggg tcctggaatc gcctccactg tgaaaactgg   1620

cgaagaagta ggctttgtgg ttgatgccaa gactgccggg aagggtaaag tgacctgcac   1680

ggttctgacc ccagatggca ctgaggccga ggccgatgtc attgagaatg aagatggaac   1740

ctatgacatc ttctacacag ctgccaagcc gggcacatat gtgatctatg tgcgcttcgg   1800

tggtgttgat attcctaaca gccccttcac tgtcatggtg accgaagagg cctatgtccc   1860

agtgagtgac atgaacggcc tgggatttaa gccttttgac ctggtcattc cgtttgctgt   1920

caggaaagga gaaatcactg gagaggtcca catgccttct gggaagacag ccacacctga   1980

gattgtggac aacaaggacg gcacggtcac tgttagatat gcccccactg aggtcgggct   2040

ccatgagatg cacatcaaat acatgggcag ccacatccct gagagcccac tccagttcta   2100

cgtgaactac cccaacagtg gaagtgtttc tgcatacggt ccaggcctcg tgtatggagt   2160

ggccaacaaa actgccacct tcaccatcgt cacagaggat gcaggagaag gtggtctgga   2220

cttggctatt gagggcccct caaaagcaga aatcagctgc attgacaata aagatgggac   2280

atgcacagtg acctacctgc cgactctgcc aggcgactac agcattctgg tcaagtacaa   2340

tgacaagcac atccctggca gccccttcac agccaagatc acagatgaca gcaggcggtg   2400

ctcccaggtg aagttgggct cagccgctga cttcctgctc gacatcagtg agactgacct   2460

cagcagcctg acggccagca ttaaggcccc atctggccga gacgagccct gtctcctgaa   2520

gaggctgccc aacaaccaca ttggcatctc cttcatcccc cgggaagtgg gcgaacatct   2580

ggtcagcatc aagaaaaatg gcaaccatgt ggccaacagc cccgtgtcta tcatggtggt   2640

ccagtcggag attggtgacg cccgccgagc caaagtctat ggccgcggcc tgtcagaagg   2700

ccggactttc gagatgtctg acttcatcgt ggacacaagg gatgcaggtt atggtggcat   2760

atccttggcg gtggaaggcc ccagcaaagt ggacatccag acggaggacc tggaagatgg   2820

cacctgcaaa gtctcctact tccctaccgt gcctggggtt tatatcgtct ccaccaaatt   2880

cgctgacgag cacgtgcctg ggagcccatt taccgtgaag atcagtgggg agggaagagt   2940

caaagagagc atcacccgca ccagtcgggc cccgtccgtg gccactgtcg ggagcatttg   3000

tgacctgaac ctgaaaatcc cagaaatcaa cagcagtgat atgtcggccc acgtcaccag   3060

cccctctggc cgtgtgactg aggcagagat tgtgcccatg gggaagaact cacactgcgt   3120

ccggtttgtg ccccaggaga tgggcgtgca cacggtcagc gtcaagtacc gtgggcagca   3180

cgtcaccggc agccccttcc agttcaccgt ggggccactt ggtgaaggag gcgcccacaa   3240

ggtgcgggca ggaggccctg gcctggagag aggagaagcg ggagtcccag ctgagttcag   3300

catttggacc cgggaagcag gcgctggagg cctctccatc gctgttgagg gccccagtaa   3360

ggccgagatt acattcgatg accataaaaa tgggtcgtgc ggtgtatctt atattgccca   3420

agagcctggt aactacgagg tgtccatcaa gttcaatgat gagcacatcc cggaaagccc   3480

ctacctggtg ccggtcatcg caccctccga cgacgcccgc cgcctcactg ttatgagcct   3540

tcaggaatcg ggattaaaag ttaaccagcc agcatccttt gctataaggt tgaatggcgc   3600

aaaaggcaag attgatgcaa aggtgcacag cccctctgga gccgtggagg agtgccacgt   3660

gtctgagctg gagccagata agtatgctgt tcgcttcatc cctcatgaga atggtgtcca   3720

caccatcgat gtcaagttca atgggagcca cgtggttgga agccccttca aagtgcgcgt   3780

tggggagcct ggacaagcgg ggaaccctgc cctggtgtcc gcctatggca cgggactcga   3840

agggggcacc acaggtatcc agtcggaatt ctttattaac accacccgag caggtccagg   3900

gacattatcc gtcaccatcg aaggcccatc caaggttaaa atggattgcc aggaaacacc   3960

tgaagggtac aaagtcatgt acacccccat ggctcctggt aactacctga tcagcgtcaa   4020

atacggtggg cccaaccaca tcgtgggcag tcccttcaag gccaaggtga caggtaacga   4080

acaaccacct tcggagttac tctcccttcc tggggagctg gttgtgtcag atcaatcata   4140

gtggaaacta tggatggttt tagatgtgtt aaagctactt tgaactttga atgtcagtaa   4200

atagtatgag atgtcagagg gcagtgtttg aaacttacaa aagtccacag agtggagccg   4260

tgcagaagtt gagaaagcat gttaggatgt taggtggttt tctatctcta acaggaaaga   4320

atacatattg aaatcttacg tatttgttta gatcagggtc tgaaaaatcc cctgatttct   4380

aattttcact tgaaaaataa tcaaaaagtt ttcctatact tataaaaatg tgtctcctcc   4440

aaaacactgg aaaaaatacc aaactatgaa aaccacttca cagccaccac ccaaggtaac   4500

caccataaac actgtagtaa atcccttcca cacgtcatga ttcactgtta cataaagaat   4560

gtaggttcat cgcaggaaaa ttagaaaatt cagatagaaa aatcatcctt tctcatccac   4620

agaatcattt tttgatattt cattatatgt catcccaaac ttttacactg cttatacata   4680

gactatttta tgtcaataga aagatgtgaa ttccacaggc acatctttgg tgggtagggg   4740

gtggggggat tgggagggtc cttggccttg tcagccaagg ccagactcat ccatttgccc   4800

agaaagccag atcctagttg tatgggggtg ggatcctagg ggtttagaag acattatggg   4860

tgtgagatac aggtgtggtg gcttttgtgt tggggtgcgc gggctctcct ggggttactg   4920

tgtagggtac tcgcctgtcc tctggctgag agacccctct tgatctggcc attcatgcct   4980

gtccccctcc ctcctgtatc ttaggccagc gtctagttag ccctggctca gccaacgaga   5040

cctcatccat cctggtggag tcagtgacca ggtcgtctac agagacctgc tatagcgcca   5100

ttcccaaggc atcctcggac gccagcaagg tgacctctaa gggggcaggg ctctcaaagg   5160

cctttgtggg ccagaagagt tccttcctgg tggactgcag caaagctggc tccaacatgc   5220

tgctgatcgg ggtccatggg cccaccaccc cctgcgagga ggtctccatg aagcatgtag   5280

gcaaccagca atacaacgtc acatacgtcg tcaaggagag gggcgattat gtgctggctg   5340

tgaagtgggg ggaggaacac atccctggca gcccttttca tgtcacagtg ccttaaaaca   5400

gttttctcaa atcctggaga gagttcttgt ggttgctttt gttgcttgtt tgtaattcat   5460

tttatacaaa gccctccagc ctgtttgtgg ggctgaaacc ccatccctaa aatattgctg   5520

ttgtaaaatg ccttcagaaa taagtcctag actggactct tgagggacat attggagaat   5580

cttaagaaat gcaagcttgt tcagggggct gagaagatcc tgagtacact aggtgcaaac   5640

cagaactctt ggtggaacag accagccact gcagcagaca gaccaggaac acaatgagac   5700

tgacatttca aaaaaacaaa actggctagc ctgagctgct ggttcactct tcagcattta   5760

tgaaacaagg ctaggggaag atgggcagag aaaaagggga cacctagttt ggttgtcatt   5820

tggcaaagga gatgacttaa aatccgctta atctcttcca gtgtccgtgt taatgtattt   5880

ggctattaga tcactagcac tgctttaccg ctcctcatcg ccaacacccc catgctctgt   5940

ggccttctta cacttctcag agggcagagt ggcagccggg caccctacag aaactcagag   6000

ggcagagtgg cagccaggcc cacatgtctc tcaagtacct gtcccctcgc tctggtgatt   6060

atttcttgca gaatcaccac acgagaccat cccggcagtc atggttttgc tttagttttc   6120

caagtccgtt tcagtccctt ccttggtctg aagaaattct gcagtggcga gcagtttccc   6180

acttgccaaa gatccctttt aaccaacact agcccttgtt tttaacacac gctccagccc   6240

ttcatcagcc tgggcagtct taccaaaatg tttaaagtga tctcagaggg gcccatggat   6300

taacgccctc atcccaaggt ccgtcccatg acataacact ccacacccgc cccagccaac   6360

ttcatgggtc actttttctg gaaaataatg atctgtacag acaggacaga atgaaactcc   6420

tgcgggtctt tggcctgaaa gttgggaatg gttgggggag agaagggcag cagcttattg   6480

gtggtctttt caccattggc agaaacagtg agagctgtgt ggtgcagaaa tccagaaatg   6540

aggtgtaggg aattttgcct gccttcctgc agacctgagc tggctttgga atgaggttaa   6600

agtgtcaggg acgttgcctg agcccaaatg tgtagtgtgg tctgggcagg cagaccttta   6660

ggttttgctg cttagtcctg aggaagtggc cactcttgtg gcaggtgtag tatctggggc   6720

gagtgttggg ggtaaaagcc caccctacag aaagtggaac agcccggagc ctgatgtgaa   6780

aggaccacgg gtgttgtaag ctgggacacg gaagccaaac tggaatcaaa cgccgactgt   6840

aaattgtatc ttataactta ttaaataaaa catttgctcc gtaaagttg               6889


<210>  9443
<211>  1053
<212>  PRT
<213>  Homosapiens

<400>  9443

Met Val Ala Gly Leu Phe Val Thr His Gln Trp Lys Pro Ile Ala Leu 
1               5                   10                  15      


Gly Asp Gly Cys Gly Pro Ile Ser Asp Ser Ala Lys Gly Gly Val Lys 
            20                  25                  30          


Val Arg Pro Gly Ser Ser Leu Asn Leu Ser Ser Leu Ser Ser Gly Leu 
        35                  40                  45              


Val Glu Pro Val Asn Val Val Asp Asn Gly Asp Gly Thr His Thr Val 
    50                  55                  60                  


Thr Tyr Thr Pro Ser Gln Glu Gly Pro Tyr Met Val Ser Val Lys Tyr 
65                  70                  75                  80  


Ala Asp Glu Glu Ile Pro Arg Ser Pro Phe Lys Val Lys Val Leu Pro 
                85                  90                  95      


Thr Tyr Asp Ala Ser Lys Val Thr Ala Ser Gly Pro Gly Leu Ser Ser 
            100                 105                 110         


Tyr Gly Val Pro Ala Ser Leu Pro Val Asp Phe Ala Ile Asp Ala Arg 
        115                 120                 125             


Asp Ala Gly Glu Gly Leu Leu Ala Val Gln Ile Thr Asp Gln Glu Gly 
    130                 135                 140                 


Lys Pro Lys Arg Ala Ile Val His Asp Asn Lys Asp Gly Thr Tyr Ala 
145                 150                 155                 160 


Val Thr Tyr Ile Pro Asp Lys Thr Gly Arg Tyr Met Ile Gly Val Thr 
                165                 170                 175     


Tyr Gly Gly Asp Asp Ile Pro Leu Ser Pro Tyr Arg Ile Arg Ala Thr 
            180                 185                 190         


Gln Thr Gly Asp Ala Ser Lys Cys Leu Ala Thr Gly Pro Gly Ile Ala 
        195                 200                 205             


Ser Thr Val Lys Thr Gly Glu Glu Val Gly Phe Val Val Asp Ala Lys 
    210                 215                 220                 


Thr Ala Gly Lys Gly Lys Val Thr Cys Thr Val Leu Thr Pro Asp Gly 
225                 230                 235                 240 


Thr Glu Ala Glu Ala Asp Val Ile Glu Asn Glu Asp Gly Thr Tyr Asp 
                245                 250                 255     


Ile Phe Tyr Thr Ala Ala Lys Pro Gly Thr Tyr Val Ile Tyr Val Arg 
            260                 265                 270         


Phe Gly Gly Val Asp Ile Pro Asn Ser Pro Phe Thr Val Met Val Thr 
        275                 280                 285             


Glu Glu Ala Tyr Val Pro Val Ser Asp Met Asn Gly Leu Gly Phe Lys 
    290                 295                 300                 


Pro Phe Asp Leu Val Ile Pro Phe Ala Val Arg Lys Gly Glu Ile Thr 
305                 310                 315                 320 


Gly Glu Val His Met Pro Ser Gly Lys Thr Ala Thr Pro Glu Ile Val 
                325                 330                 335     


Asp Asn Lys Asp Gly Thr Val Thr Val Arg Tyr Ala Pro Thr Glu Val 
            340                 345                 350         


Gly Leu His Glu Met His Ile Lys Tyr Met Gly Ser His Ile Pro Glu 
        355                 360                 365             


Ser Pro Leu Gln Phe Tyr Val Asn Tyr Pro Asn Ser Gly Ser Val Ser 
    370                 375                 380                 


Ala Tyr Gly Pro Gly Leu Val Tyr Gly Val Ala Asn Lys Thr Ala Thr 
385                 390                 395                 400 


Phe Thr Ile Val Thr Glu Asp Ala Gly Glu Gly Gly Leu Asp Leu Ala 
                405                 410                 415     


Ile Glu Gly Pro Ser Lys Ala Glu Ile Ser Cys Ile Asp Asn Lys Asp 
            420                 425                 430         


Gly Thr Cys Thr Val Thr Tyr Leu Pro Thr Leu Pro Gly Asp Tyr Ser 
        435                 440                 445             


Ile Leu Val Lys Tyr Asn Asp Lys His Ile Pro Gly Ser Pro Phe Thr 
    450                 455                 460                 


Ala Lys Ile Thr Asp Asp Ser Arg Arg Cys Ser Gln Val Lys Leu Gly 
465                 470                 475                 480 


Ser Ala Ala Asp Phe Leu Leu Asp Ile Ser Glu Thr Asp Leu Ser Ser 
                485                 490                 495     


Leu Thr Ala Ser Ile Lys Ala Pro Ser Gly Arg Asp Glu Pro Cys Leu 
            500                 505                 510         


Leu Lys Arg Leu Pro Asn Asn His Ile Gly Ile Ser Phe Ile Pro Arg 
        515                 520                 525             


Glu Val Gly Glu His Leu Val Ser Ile Lys Lys Asn Gly Asn His Val 
    530                 535                 540                 


Ala Asn Ser Pro Val Ser Ile Met Val Val Gln Ser Glu Ile Gly Asp 
545                 550                 555                 560 


Ala Arg Arg Ala Lys Val Tyr Gly Arg Gly Leu Ser Glu Gly Arg Thr 
                565                 570                 575     


Phe Glu Met Ser Asp Phe Ile Val Asp Thr Arg Asp Ala Gly Tyr Gly 
            580                 585                 590         


Gly Ile Ser Leu Ala Val Glu Gly Pro Ser Lys Val Asp Ile Gln Thr 
        595                 600                 605             


Glu Asp Leu Glu Asp Gly Thr Cys Lys Val Ser Tyr Phe Pro Thr Val 
    610                 615                 620                 


Pro Gly Val Tyr Ile Val Ser Thr Lys Phe Ala Asp Glu His Val Pro 
625                 630                 635                 640 


Gly Ser Pro Phe Thr Val Lys Ile Ser Gly Glu Gly Arg Val Lys Glu 
                645                 650                 655     


Ser Ile Thr Arg Thr Ser Arg Ala Pro Ser Val Ala Thr Val Gly Ser 
            660                 665                 670         


Ile Cys Asp Leu Asn Leu Lys Ile Pro Glu Ile Asn Ser Ser Asp Met 
        675                 680                 685             


Ser Ala His Val Thr Ser Pro Ser Gly Arg Val Thr Glu Ala Glu Ile 
    690                 695                 700                 


Val Pro Met Gly Lys Asn Ser His Cys Val Arg Phe Val Pro Gln Glu 
705                 710                 715                 720 


Met Gly Val His Thr Val Ser Val Lys Tyr Arg Gly Gln His Val Thr 
                725                 730                 735     


Gly Ser Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly Ala 
            740                 745                 750         


His Lys Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Gly Glu Ala Gly 
        755                 760                 765             


Val Pro Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala Gly Gly 
    770                 775                 780                 


Leu Ser Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Thr Phe Asp 
785                 790                 795                 800 


Asp His Lys Asn Gly Ser Cys Gly Val Ser Tyr Ile Ala Gln Glu Pro 
                805                 810                 815     


Gly Asn Tyr Glu Val Ser Ile Lys Phe Asn Asp Glu His Ile Pro Glu 
            820                 825                 830         


Ser Pro Tyr Leu Val Pro Val Ile Ala Pro Ser Asp Asp Ala Arg Arg 
        835                 840                 845             


Leu Thr Val Met Ser Leu Gln Glu Ser Gly Leu Lys Val Asn Gln Pro 
    850                 855                 860                 


Ala Ser Phe Ala Ile Arg Leu Asn Gly Ala Lys Gly Lys Ile Asp Ala 
865                 870                 875                 880 


Lys Val His Ser Pro Ser Gly Ala Val Glu Glu Cys His Val Ser Glu 
                885                 890                 895     


Leu Glu Pro Asp Lys Tyr Ala Val Arg Phe Ile Pro His Glu Asn Gly 
            900                 905                 910         


Val His Thr Ile Asp Val Lys Phe Asn Gly Ser His Val Val Gly Ser 
        915                 920                 925             


Pro Phe Lys Val Arg Val Gly Glu Pro Gly Gln Ala Gly Asn Pro Ala 
    930                 935                 940                 


Leu Val Ser Ala Tyr Gly Thr Gly Leu Glu Gly Gly Thr Thr Gly Ile 
945                 950                 955                 960 


Gln Ser Glu Phe Phe Ile Asn Thr Thr Arg Ala Gly Pro Gly Thr Leu 
                965                 970                 975     


Ser Val Thr Ile Glu Gly Pro Ser Lys Val Lys Met Asp Cys Gln Glu 
            980                 985                 990         


Thr Pro Glu Gly Tyr Lys Val Met  Tyr Thr Pro Met Ala  Pro Gly Asn 
        995                 1000                 1005             


Tyr Leu  Ile Ser Val Lys Tyr  Gly Gly Pro Asn His  Ile Val Gly 
    1010                 1015                 1020             


Ser Pro  Phe Lys Ala Lys Val  Thr Gly Asn Glu Gln  Pro Pro Ser 
    1025                 1030                 1035             


Glu Leu  Leu Ser Leu Pro Gly  Glu Leu Val Val Ser  Asp Gln Ser 
    1040                 1045                 1050             


<210>  9444
<211>  873
<212>  DNA
<213>  Homosapiens

<400>  9444
ctgccagtct acctgtggac tttgcaattg atgcccgaga tgccggggaa ggcctgcttg     60

tgttgtaaaa tgccttcaga aataagtcct agactggact cttgagggac atattggaga    120

atcttaagaa atgcaagctt gttcaggggg ctgagaagat cctgagtaca ctaggtgcaa    180

accagaactc ttggtggaac agaccagcca ctgcagcaga cagaccagga acacaatgag    240

actgacattt caaaaaaaca aaactggcta gcctgagctg ctggttcagc cctcatccca    300

aggtccgtcc catgacataa cactccacac ccgccccagc caacttcatg ggtcactttt    360

tctggaaaat aatgatctgt acagacagga cagaatgaaa ctcctgcggg tctttggcct    420

gaaagttggg aatggttggg ggagagaagg gcagcagctt attggtggtc ttttcaccat    480

tggcagaaac agtgagagct gtgtggtgca gaaatccaga aatgaggtgt agggaatttt    540

gcctgccttc ctgcagacct gagctggctt tggaatgagg ttaaagtgtc agggacgttg    600

cctgagccca aatgtgtagt gtggtctggg caggcagacc tttaggtttt gctgcttagt    660

cctgaggaag tggccactct tgtggcaggt gtagtatctg gggcgagtgt tgggggtaaa    720

agcccaccct acagaaagtg gaacagcccg gagcctgatg tgaaaggacc acgggtgttg    780

taagctggga cacggaagcc aaactggaat caaacgccga ctgtaaattg tatcttataa    840

cttattaaat aaaacatttg ctccgtaaag ttg                                 873


<210>  9445
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  9445

Met Val Gly Gly Glu Lys Gly Ser Ser Leu Leu Val Val Phe Ser Pro 
1               5                   10                  15      


Leu Ala Glu Thr Val Arg Ala Val Trp Cys Arg Asn Pro Glu Met Arg 
            20                  25                  30          


Cys Arg Glu Phe Cys Leu Pro Ser Cys Arg Pro Glu Leu Ala Leu Glu 
        35                  40                  45              


<210>  9446
<211>  528
<212>  DNA
<213>  Homosapiens

<400>  9446
ttcgtggagc acggatggtg acgcaaagga gaaaaacact cttaaatgaa caatgtcaaa     60

agttgacaag tgtttacatt tacatacttg agacataaaa gagcctccag atctctggca    120

tgctgtttac agataaacag acgtcgatgg aagggaataa tactacaaca gagtatagac    180

tgttcggaag aaagtccctg agctttggag tttggaatgg agtcttcatg cacctctcca    240

ttgctgcaca aaatgaaata attagaaggt gctttgtcgg ctgtgcacaa ggccaggtca    300

ttaagggcct ataaaccttg tggtcaagtg cggctgctga ccacagtatc aaaggacacc    360

agtgaggatg acagcatggt atttggtgtc tgtctagacc aagcatgctt catttgtaaa    420

aaagccaacg atgcttggtt ttgagggttc aatgaggtaa tgtccccaag gtttctaacc    480

cttttcctgg ttgaagaata ttcagaagaa gatctattat gtaataat                 528


<210>  9447
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  9447

Met Leu Phe Thr Asp Lys Gln Thr Ser Met Glu Gly Asn Asn Thr Thr 
1               5                   10                  15      


Thr Glu Tyr Arg Leu Phe Gly Arg Lys Ser Leu Ser Phe Gly Val Trp 
            20                  25                  30          


Asn Gly Val Phe Met His Leu Ser Ile Ala Ala Gln Asn Glu Ile Ile 
        35                  40                  45              


Arg Arg Cys Phe Val Gly Cys Ala Gln Gly Gln Val Ile Lys Gly Leu 
    50                  55                  60                  


<210>  9448
<211>  2058
<212>  DNA
<213>  Homosapiens

<400>  9448
tgtggaaatg aagcatctct ttctgttttc tctttgagat ggtttgagtt agattgtgtc     60

tcttccaagc ttgccacacc ccagtgcctc cagtcatctg ctttcttgaa ggatggccac    120

gctggtgaat tctagacaaa ttctaacccg gggagagggc tggagaattt ctggtcctgg    180

ttgggagata ctccctgtta aaccttcgga tatgctgacc tagctgaggt agccaggggc    240

tatttaaaaa ttcaaaatct cagatctggc tgtggataaa cccccaaggt ggtacgtgca    300

gtacttggag gcgtgagggc agaaggtcct ccccagcagt ttgtacggga cacatcatct    360

atgggatatt agtaaatatc cttaaggaaa ggcttctgtg gtcaaaacca ggttcagcag    420

gttatttcac tatggggctt ctcaggacgc ttaacctact catccccctc tgggctttgc    480

aaacgaggcc gccattgctt tctttctgct atgtagaaat agattgaggc gtaagggtcg    540

gatgtccttt ctccattcat caggctccct cttcctgagg agctgctgtc agaacagcct    600

ggggctgctg tgttgcaggt tatggtggca tatccttggc ggtggaaggc cccagcaaag    660

tggacatcca gacggaggac ctggaagatg gcacctgcaa agtctcctac ttccctaccg    720

tgcctggggt ttatatcgtc tccaccaaat tcgctgacga gcacgtgcct gggagcccat    780

ttaccgtgaa gatcagtggg gagggaagag tcaaagagag catcacccgc accagtcggg    840

ccccgtccgt ggccactgtc gggagcattt gtgacctgaa cctgaaaatc ccaggtgggc    900

gtcggggact agtagggtgg ggaagccttg gctccagcct tcagggcagt gggtgccttt    960

gggaaccaag tttaggcatg gcccagaaca cagtatccaa gtcggctgtg ctgacctttt   1020

catttcactt catttcatta tgttcttcta tgtttatttt cacagagtct catccaagaa   1080

aaacaaatgt ttaccttgct acctttttcc tcttccaaat aaaaatagct ttattgtgtc   1140

acatggggga aacgtagata tgcttttaga tttttagatt aactatctgt caaatagaat   1200

catgtcagtg aaagaactgg ccctgccgat gccagggtct ggaagtattt aagaggtggc   1260

agcccagcgg catccttcta gtatttctct ttcattcctg aaattagaac gagggctgtg   1320

ctgcagaact cgctgggcca catctagccc tttggtggtg aattgttctt cttgggcccc   1380

gattagccag tcaacaggtc acacagtctg tctgaaatgt gttccaagtt ctttctataa   1440

agaatccttc cagagggaag ccactgtgag tgaaaatttt gaggctcctc tgcccagaag   1500

ttggcatgtc ctgtggaatt gcacaaattc tacagagaag ggaaatctaa atcgtcttca   1560

gatggagctt gtgttgcgag ctctggagag ggggttgtct ttctacactg catctcccat   1620

ccttcctaac gagtcacgga gctgtcgact ccgccttctt ggctttagtt aacaggttct   1680

tcttgtgtag tcacatcaac gtcgggtcac atgggaatgt ggtaaagcct cattactgta   1740

gagttcagac atgatcactt aaaaagagct ttattgggcc gggcgcggtg gcttactcct   1800

ataatcccag cactttgggg ggccgaggca ggcagatcac ctgaggtcag gagttcgaga   1860

ccagcctggc taacatggca aaaccctatc tcttctaaaa atacaaaaat aagcagggcg   1920

tggtggcggg cacctgtaat cccacctact caggaggctg aggcacaaga attgcgtaaa   1980

cctgggaggt ggaggttgca gtgagctgaa attgcaccgc tgcactccag cctgggcaac   2040

aaagtgagac tccttctc                                                 2058


<210>  9449
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  9449

Met Val Ala Tyr Pro Trp Arg Trp Lys Ala Pro Ala Lys Trp Thr Ser 
1               5                   10                  15      


Arg Arg Arg Thr Trp Lys Met Ala Pro Ala Lys Ser Pro Thr Ser Leu 
            20                  25                  30          


Pro Cys Leu Gly Phe Ile Ser Ser Pro Pro Asn Ser Leu Thr Ser Thr 
        35                  40                  45              


Cys Leu Gly Ala His Leu Pro 
    50                  55  


<210>  9450
<211>  4316
<212>  DNA
<213>  Homosapiens

<400>  9450
gccaaataca ttaacacgga cactggaaga gattaagcgg attttaagtc atctcctttg     60

ccaaatgaca accaaactag gtgtcccctt tttctctgcc catcttcccc tagccttgtt    120

tcataaatgc tgaagagtga accagcagct caggctagcc agttttgttt ttttgaaatg    180

tcagtctcat tgtgttcctg gtctgtctgc tgcagtggct ggtctgttcc accaagagtt    240

ctggtttgca cctagtgtac tcaggatctt ctcagccccc tgaacaagct tgcatttctt    300

aagattctcc aatatgtccc tcaagagtcc agtctaggac ttatttctga aggcatttta    360

caacagcaat attttaggga tggggtttca gccccacaaa caggctggag ggctttgtat    420

aaaatgaatt acaaacaagc aacaaaagca accacaagaa ctctctccag gatttgagaa    480

aactgtttta aggcactgtg acatgaaaag ggctgccagg gatgtgttcc tccccccact    540

tcacagccag cacataatcg cccctctcct tgacgacgta tgtgacgttg tattgctggt    600

tgcctacatg cttcatggag acctcctcgc agggggtggt gggcccatgg accccgatca    660

gcagcatgtt ggagcctagg aggcaaaagg tggttactcc acccggatgc atcaggacag    720

gcacaggaag aagaggaaat atgagagcca aaggaaagga agcagaggca cagtgaagtc    780

agataattca tctggagtca cacagctggg gaccagcaga actgggattt aaacataaag    840

tctgtccaac ttggagctaa agcacttacc tgagagaaga tggaaggaaa aaaatccaca    900

agcagaagtc tctcaccact gcctctagct ataacctgta tctgacacca caaaacatct    960

ctgggcgtgg cggtcttccc ccaccccctc aaatatgtcc agctcagttc ctgtgagttt   1020

aatgcatgtt aaacgcagca ctgcttgttc ttcaaggcag ttaaggaagg aggcccttct   1080

ggtatacccc gagcacactg gggttcctgg accatttcat taggaaaatt gctcagcggc   1140

tccaaagaat ctggagctcc ctggtctatc tcccagcctc tcaagccgcc tccagcaggg   1200

tcccgcccca aattctccac attcccctac tccaaaatct acagaatgga ccatttaaag   1260

cttgagccaa gagatacagc aaactcaccc attaaaaaca gagggaggtt tgctttgttc   1320

agaaggtcag gatactgggc gctctggcgg ccaagcacag ataccttttc attccatgca   1380

cactgcagct gtgtaatctc agaatggata tttagggaaa ggcttgggag caggagggct   1440

ggaaaaacaa ggcgccttcc ctgtgacaag agcaatattt acacagggtt tgaagcaggc   1500

ggttctgtac ctctcccctc ctggctagga gcttccctgc aagagcaact ccttctctca   1560

gcagcgtcca gcacttgcag agcacagcct gaaacccaag ctcccaaaaa ggtgtgcgaa   1620

cagccaaaag gaaatgggag agggcccagg cacagcggca tgagccagca ggagggtgag   1680

atgcttcctg gccagtgtgg gagaccccag cagctgctgt gaggcctggc ctgaagcctg   1740

ccacgcgctc caagtgccga gaggacccca cctgggccct caaaggtgag taccttgtca   1800

gggcccaagt gccagcactg ctgcctggaa agtactcctg agtggctggg aggacagggg   1860

tcctggttta ggacatcccc aaagtgggct ggggatgcag tcactgcctc tgggtgagcc   1920

agccacttag agagggggcc aagctcgggg gttcagcgca taggctctga ggtcacggat   1980

gtagactgat tcctggttct gcctcctccc agctgactgc tttttggggg agtgttgttt   2040

ggggagtgac tcaacctctg catctcactt tccacatctg taaaatggac atcacttacg   2100

gtaaaatgat accatgcctt tcacaaaagg caagccgcag gcccagagtt cagcgtggag   2160

ccgggctgga tttgcctggg gagtctggca gcactcacac cacccctgtg ggtggctttg   2220

ctgaggccac tgctttggcc agagtcccgg gcagcctgcc agcccaccag tcactcctgc   2280

acccggagag ggccccttgg ccacacaggt cacttgctcc tagggctgga tgccaggcaa   2340

ccatgcagcc actcacccct cacccctggg aggcaagtct gctccatccc actctcctta   2400

tgcggggtgg gggtacacac acaagagact caagaaacca ggacatactg ctttcccaag   2460

agggtccaaa gtaacaccaa atgcaaacat gccccagtga gtccacactg cgcacttccc   2520

ctgcaaagac taaggactga ctctccaccc tggcagcctc cataacagtg acgcactcac   2580

tgcgcaccac ccgatgccac ctgttcaaat aactgcgatt cacagcagga attctcacta   2640

cagccaggaa aaggagggga agatctgttc tgacatggaa agatctttaa gatgtcaaag   2700

caaaaacaca agctatacca cacagtggat acagtaagat tctttctgta agacaaaagc   2760

aaaactctgt gtctgcttgt ctaatgaacc aattagctaa ccaacccagc aaccaagaat   2820

gaagacagac aatgagatga cagacagggt gaaggtcctc ccttcccaga gccgtttgct   2880

tccagaccca ggtgggggag gaggagagaa gatggagtga gtctcacttt atttacttct   2940

tcactgcctg tatctttcat aatcaaacat gtcccatctg tggcaaagaa taaaagtaaa   3000

ttgtaacggg tctaaaaagc ttcagaattc tttgaacatt tcagtctttt ctcctcctcc   3060

attaagatct gagagtaaaa agaggaggag ataggctggg acaggtctta ttgctgcttc   3120

agtgcatttc tgggagcctg gtaccatgaa agaacagacg ggtaggagcc cacttggacg   3180

catcatgaat tctgtgcagg caaagaaacc ctcaaaatta atgacactgt gctgtgttcc   3240

ctgactatca gcatcctgtt ctgaaagtca agaaacttgg cagaggaagg aatctgaatc   3300

acaactaaca gtaatgaggt gtgataacac ggccatcgag ctctcactct ggatttatcg   3360

tgggtcaaac cgcaactccc aaaacagctt tggacagcaa gcgcctccga agtgtgcatg   3420

accccagttt ccacggggag tacgtgtaaa aagctttcat ggggcttgag gatttccatc   3480

tggcttggtc cctggagctg gttcagttaa ggcttcaaga agcagaagag tgggttacct   3540

gtggtgcccc cttcgagtcc cgtgccatag gcggacacca gggcagggtt ccccgcttgt   3600

ccaggctccc caacgcgcac tttgaagggg cttccaacca cgtggctccc attgaacttg   3660

acatcgatgg tgtggacacc attctcatga gggatgaagc gaacagcata cttatctagg   3720

agaatgagca aaggcacagg gtgaaatcaa gcaaatggac acccctgagt tcagtgagga   3780

taaaggatgg aggccaagct gagatggccc atttaaaatc aacagttcta cagggagcct   3840

ggcactcagc atcctggatt tcagaaccag acagaccccc tgggtatccc tcatcagccc   3900

caagggaaac gcatccacat tgcaaatcct ataaacacag gacaagactc tgacccctgc   3960

ctcagaagaa cacttccttt ctttagaaaa cctcacttct tcagtgtgaa attctgtgaa   4020

tgctgttact aatcctgtca cgagatgaat ctcatttcac caaaattaaa ttatgttttt   4080

ccactaaaat gatgatacaa gttgaagaca cagcactctg aaattggaag acctcaccac   4140

ttaaggctcc gcagcggctt actcagctga actccaggtt actactcttt actttgttca   4200

cccattgggg agttcagttt gtttttaaac attgggagat ggccattcta actactgttc   4260

aatgtctctg ttttgggaag gcataacaag aaataaaaag gaatatatat gaaggg       4316


<210>  9451
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  9451

Met Glu Thr Ser Ser Gln Gly Val Val Gly Pro Trp Thr Pro Ile Ser 
1               5                   10                  15      


Ser Met Leu Glu Pro Arg Arg Gln Lys Val Val Thr Pro Pro Gly Cys 
            20                  25                  30          


Ile Arg Thr Gly Thr Gly Arg Arg Gly Asn Met Arg Ala Lys Gly Lys 
        35                  40                  45              


Glu Ala Glu Ala Gln 
    50              


<210>  9452
<211>  2462
<212>  DNA
<213>  Homosapiens

<400>  9452
gggagagctg gactctggtg gctgaagcag cacttcaggc tcacagtgtg actcaggctt     60

cttgccctca gccacaatgg ctcatgccca gaggagagaa cagggtgtcc aggctgttgg    120

tgcttgtggg cgaaatgtca gccatgctcc tcctgccttg gcctagaaaa gggagccccc    180

accccgcagg gcctgaggtt ctctctgcca gaagttcaga gctagtgcca gtgggttccc    240

atgccaccag ggtgagccct ctgtaagggg atctatgtgt gtccctcacc acggcctcag    300

tgctcccagg aaagccctcc aagtcatcaa cacagcattt tctattcctt tctcccaggt    360

atccagtcgg aattctttat taacaccacc cgagcaggtc cagggacatt atccgtcacc    420

atcgaaggcc catccaaggt taaaatggat tgccaggaaa cacctgaagg gtacaaagtc    480

atgtacaccc ccatggctcc tggtaactac ctgatcagcg tcaaatacgg tgggcccaac    540

cacatcgtgg gcagtccctt caaggccaag gtgacaggcc agcgtctagt tagccctggc    600

tcagccaacg agacctcatc catcctggtg gagtcagtga ccaggtcgtc tacagagacc    660

tgctatagcg ccattcccaa ggcatcctcg gacgccagca aggtgacctc taagggggca    720

gggctctcaa aggcctttgt gggccagaag agttccttcc tggtggactg cagcaaagct    780

ggctccaaca tgctgctgat cggggtccat gggcccacca ccccctgcga ggaggtctcc    840

atgaagcatg taggcaacca gcaatacaac gtcacatacg tcgtcaagga gaggggcgat    900

tatgtgctgg ctgtgaagtg gggggaggaa cacatccctg gcagcccttt tcatgtcaca    960

gtgccttaaa acagttttct caaatcctgg agagagttct tgtggttgct tttgttgctt   1020

gtttgtaatt cattttatac aaagccctcc agcctgtttg tggggctgaa accccatccc   1080

taaaatattg ctgttgtaaa atgccttcag aaataagtcc tagactggac tcttgaggga   1140

catattggag aatcttaaga aatgcaagct tgttcagggg gctgagaaga tcctgagtac   1200

actaggtgca aaccagaact cttggtggaa cagaccagcc actgcagcag acagaccagg   1260

aacacaatga gactgacatt tcaaaaaaac aaaactggct agcctgagct gctggttcac   1320

tcttcagcat ttatgaaaca aggctagggg aagatgggca gagaaaaagg ggacacctag   1380

tttggttgtc atttggcaaa ggagatgact taaaatccgc ttaatctctt ccagtgtccg   1440

tgttaatgta tttggctatt agatcactag cactgcttta ccgctcctca tcgccaacac   1500

ccccatgctc tgtggccttc ttacacttct cagagggcag agtggcagcc gggcacccta   1560

cagaaactca gagggcagag tggcagccag gcccacatgt ctctcaagta cctgtcccct   1620

cgctctggtg attatttctt gcagaatcac cacacgagac catcccggca gtcatggttt   1680

tgctttagtt ttccaagtcc gtttcagtcc cttccttggt ctgaagaaat tctgcagtgg   1740

cgagcagttt cccacttgcc aaagatccct tttaaccaac actagccctt gtttttaaca   1800

cacgctccag cccttcatca gcctgggcag tcttaccaaa atgtttaaag tgatctcaga   1860

ggggcccatg gattaacgcc ctcatcccaa ggtccgtccc atgacataac actccacacc   1920

cgccccagcc aacttcatgg gtcacttttt ctggaaaata atgatctgta cagacaggac   1980

agaatgaaac tcctgcgggt ctttggcctg aaagttggga atggttgggg gagagaaggg   2040

cagcagctta ttggtggtct tttcaccatt ggcagaaaca gtgagagctg tgtggtgcag   2100

aaatccagaa atgaggtgta gggaattttg cctgccttcc tgcagacctg agctggcttt   2160

ggaatgaggt taaagtgtca gggacgttgc ctgagcccaa atgtgtagtg tggtctgggc   2220

aggcagacct ttaggttttg ctgcttagtc ctgaggaagt ggccactctt gtggcaggtg   2280

tagtatctgg ggcgagtgtt gggggtaaaa gcccacccta cagaaagtgg aacagcccgg   2340

agcctgatgt gaaaggacca cgggtgttgt aagctgggac acggaagcca aactggaatc   2400

aaacgccgac tgtaaattgt atcttataac ttattaaata aaacatttgc tccgtaaagt   2460

tg                                                                  2462


<210>  9453
<211>  174
<212>  PRT
<213>  Homosapiens

<400>  9453

Met Asp Cys Gln Glu Thr Pro Glu Gly Tyr Lys Val Met Tyr Thr Pro 
1               5                   10                  15      


Met Ala Pro Gly Asn Tyr Leu Ile Ser Val Lys Tyr Gly Gly Pro Asn 
            20                  25                  30          


His Ile Val Gly Ser Pro Phe Lys Ala Lys Val Thr Gly Gln Arg Leu 
        35                  40                  45              


Val Ser Pro Gly Ser Ala Asn Glu Thr Ser Ser Ile Leu Val Glu Ser 
    50                  55                  60                  


Val Thr Arg Ser Ser Thr Glu Thr Cys Tyr Ser Ala Ile Pro Lys Ala 
65                  70                  75                  80  


Ser Ser Asp Ala Ser Lys Val Thr Ser Lys Gly Ala Gly Leu Ser Lys 
                85                  90                  95      


Ala Phe Val Gly Gln Lys Ser Ser Phe Leu Val Asp Cys Ser Lys Ala 
            100                 105                 110         


Gly Ser Asn Met Leu Leu Ile Gly Val His Gly Pro Thr Thr Pro Cys 
        115                 120                 125             


Glu Glu Val Ser Met Lys His Val Gly Asn Gln Gln Tyr Asn Val Thr 
    130                 135                 140                 


Tyr Val Val Lys Glu Arg Gly Asp Tyr Val Leu Ala Val Lys Trp Gly 
145                 150                 155                 160 


Glu Glu His Ile Pro Gly Ser Pro Phe His Val Thr Val Pro 
                165                 170                 


<210>  9454
<211>  415
<212>  DNA
<213>  Homosapiens

<400>  9454
aggccagcgt ctagttagcc ctggctcagc caacgagacc tcatccatcc tggtggagtc     60

agtgaccagg tcgtctacag agacctgcta tagcgccatt cccaaggcat cctcggacgc    120

cagcaaggtg acctctaagg gggcagggct ctcaaaggcc tttgtgggcc agaagagttc    180

cttcctggtg gactgcagca aagctggctc caacatgctg ctgatcgggg tccatgggcc    240

caccaccccc tgcgaggagg tctccatgaa gcatgtaggc aaccagcaat acaacgtcac    300

atacgtcgtc aaggagaggg gcgattatgt gctggctgtg aagtgggggg aggaacacat    360

ccctggcagc ccttttcatg tcacagtgcc ttaaaacagt tttctcaaat cctgg         415


<210>  9455
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  9455

Met Leu Leu Ile Gly Val His Gly Pro Thr Thr Pro Cys Glu Glu Val 
1               5                   10                  15      


Ser Met Lys His Val Gly Asn Gln Gln Tyr Asn Val Thr Tyr Val Val 
            20                  25                  30          


Lys Glu Arg Gly Asp Tyr Val Leu Ala Val Lys Trp Gly Glu Glu His 
        35                  40                  45              


Ile Pro Gly Ser Pro Phe His Val Thr Val Pro 
    50                  55                  


<210>  9456
<211>  1344
<212>  DNA
<213>  Homosapiens

<400>  9456
atgaagcatg taggcaacca gcaatacaac gtcacatacg tcgtcaagga gaggggcgat     60

tatgtgctgg ctgtgaagtg gggggaggaa cacatccctg gcagcccttt tcatgtcaca    120

gtgccttaaa acagttttct caaatcctgg agagagttct tgtggttgct tttgttgctt    180

gtttgtaatt cattttatac aaagccctcc agcctgtttg tggggctgaa accccatccc    240

taaaatattg ctgttgtaaa atgccttcag aaataagtcc tagactggac tcttgaggga    300

catattggag aatcttaaga aatgcaagct tgttcagggg gctgagaaga tcctgagtac    360

actaggtgca aaccagaact cttggtggaa cagaccagcc actgcagcag acagaccagg    420

aacacaatga gactgacatt tcaaaaaaac aaaactggct agcctgagct gctggttcac    480

tcttcagcat ttatgaaaca aggctagggg aagatgggca gagaaaaagg ggacacctag    540

tttggttgtc atttggcaaa ggagatgact taaaatccgc ttaatctctt ccagtgtccg    600

tgttaatgta tttggctatt agatcactag cactgcttta ccgctcctca tcgccaacac    660

ccccatgctc tgtggccttc ttacacttct cagagggcag agtggcagcc gggcacccta    720

cagaaactca gagggcagag tggcagccag gcccacatgt ctctcaagta cctgtcccct    780

cgctctggtg attatttctt gcagaatcac cacacgagac catcccggca gtcatggttt    840

tgctttagtt ttccaagtcc gtttcagtcc cttccttggt ctgaagaaat tctgcagtgg    900

cgagcagttt cccacttgcc aaagatccct tttaaccaac actagccctt gtttttaaca    960

cacgctccag cccttcatca gcctgggcag tcttaccaaa atgtttaaag tgatctcaga   1020

ggggcccatg gattaacgcc ctcatcccaa ggtccgtccc atgacataac actccacacc   1080

cgccccagcc aacttcatgg gtcacttttt ctggaaaata atgatctgta cagacaggac   1140

agaagtggcc actcttgtgg caggtgtagt atctggggcg agtgttgggg gtaaaagccc   1200

accctacaga aagtggaaca gcccggagcc tgatgtgaaa ggaccacggg tgttgtaagc   1260

tgggacacgg aagccaaact ggaatcaaac gccgactgta aattgtatct tataacttat   1320

taaataaaac atttgctccg taaa                                          1344


<210>  9457
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  9457

Met Gly His Phe Phe Trp Lys Ile Met Ile Cys Thr Asp Arg Thr Glu 
1               5                   10                  15      


Val Ala Thr Leu Val Ala Gly Val Val Ser Gly Ala Ser Val Gly Gly 
            20                  25                  30          


Lys Ser Pro Pro Tyr Arg Lys Trp Asn Ser Pro Glu Pro Asp Val Lys 
        35                  40                  45              


Gly Pro Arg Val Leu 
    50              


<210>  9458
<211>  778
<212>  DNA
<213>  Homosapiens

<400>  9458
cttgtggttg cttttgttgc ttgtttgtaa ttcattttat acaaagccct ccagcctgtt     60

tgtggggctg aaaccccatc cctaaaatat tgctgttgta aaatgccttc agaaataagt    120

cctagactgg actcttgagg gacatattgg agaatcttaa gaaatgcaag cttgttcagg    180

gggctgagaa gatcctgagt acactaggtg caaaccagaa ctcttggtgg aacagaccag    240

ccactgcagc agacagacca ggaacacaat gagactgaca tttcaaaaaa acaaaactgg    300

ctagcctgag ctgctggttc actcttcagc atttatgaaa caaggctagg ggaagatggg    360

cagagaaaaa ggggacacct agtttggttg tcatttggca aaggagatga cttaaaaaat    420

ccagaaatga ggtgtaggga attttgcctg ccttcctgca gacctgagct ggctttggaa    480

tgaggttaaa gtgtcaggga cgttgcctga gcccaaatgt gtagtgtggt ctgggcaggc    540

agacctttag gttttgctgc ttagtcctga ggaagtggcc actcttgtgg caggtgtagt    600

atctggggcg agtgttgggg gtaaaagccc accctacaga aagtggaaca gcccggagcc    660

tgatgtgaaa ggaccacggg tgttgtaagc tgggacacgg aagccaaact ggaatcaaac    720

gccgactgta aattgtatct tataacttat taaataaaac atttgctccg taaagttg      778


<210>  9459
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  9459

Thr Gly Leu Leu Arg Asp Ile Leu Glu Asn Leu Lys Lys Cys Lys Leu 
1               5                   10                  15      


Val Gln Gly Ala Glu Lys Ile Leu Ser Thr Leu Gly Ala Asn Gln Asn 
            20                  25                  30          


Ser Trp Trp Asn Arg Pro Ala Thr Ala Ala Asp Arg Pro Gly Thr Gln 
        35                  40                  45              


<210>  9460
<211>  1296
<212>  DNA
<213>  Homosapiens

<400>  9460
agatgtcaga gctggctccc ggttgggata tgagtgactt tgtggaggat ggcgcctaaa     60

tgaggcatgc caatttctgc accagggtga cgaacataag ggctccttaa aggctagccc    120

aatgtatctg tatttccttg gggattaaaa cccatgatct tcagttcctc agagaactga    180

aagttgcaag gagaaatcca gtaattcctg ttatctgcag gctttataag tcagtggagc    240

ctgcggaagt ggccagaatc cagcactcca agcactgctg tcttctcaca gagtcttgaa    300

gccagagcag cgccaggatg tcacgggagc tggccccact gctgcttctc ctcctctcca    360

tccacagcgc cctggccatg aggatctgct ccttcaacgt caggtccttt ggggaaagca    420

agcaggaaga caagaatgcc atggatgtca ttgtgaaggt catcaaacgc tgtgacatca    480

tactcgtgat ggaaatcaag gacagcaaca acaggatctg ccccatactg atggagaagc    540

tgaacagaaa ttcaaggaga ggcataacgt acaactatgt gattagctct cggcttggaa    600

gaaacacata taaagaacaa tatgcctttc tctacaagga aaagctggtg tctgtgaaga    660

ggagttatca ctaccatgac tatcaggatg gagacgcaga tgtgttttcc agggagccct    720

ttgtggtctg gttccaatct ccccacactg ctgtcaaaga cttcgtgatt atccccctgc    780

acaccacccc agagacatcc gttaaggaga tcgatgagtt ggttgaggtc tacacggacg    840

tgaaacaccg ctggaaggcg gagaatttca ttttcatggg tgacttcaat gccggctgca    900

gctacgtccc caagaaggcc tggaagaaca tccgcttgag gactgacccc aggtttgttt    960

ggctgatcgg ggaccaagag gacaccacgg tgaagaagag caccaactgt gcatatgaca   1020

ggattgtgct tagaggacaa gaaatcgtca gttctgttgt tcccaagtca aacagtgttt   1080

ttgacttcca gaaagcttac aagctgactg aagaggaggc cctggatgtc agcgaccact   1140

ttccagttga atttaaacta cagtcttcaa gggccttcac caacagcaaa aaatctgtca   1200

ctctaaggaa gaaaacaaag agcaaacgct cctagaccca agggtctcat cttattaacc   1260

atttcttgcc tctaaataaa atgtctctaa cagata                             1296


<210>  9461
<211>  305
<212>  PRT
<213>  Homosapiens

<400>  9461

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Lys Lys Ser Val Thr Leu Arg Lys Lys Thr Lys Ser Lys Arg 
    290                 295                 300                 


Ser 
305 


<210>  9462
<211>  702
<212>  DNA
<213>  Homosapiens

<400>  9462
agagcagcgc caggatgtca cgggagctgg ccccactgct gcttctcctc ctctccatcc     60

acagcgccct ggccatgagg atctgctcct tcaacgtcag gtcctttggg gaaagcaagc    120

aggaagacaa gaatgccatg gatgtcattg tgaaggtcat caaacgctgt gacatcatac    180

tcgtgatgga aatcaaggac agcaacaaca ggatctgccc catactgatg gagaagctga    240

acaggtaaca tggggaaggg tgggccctct agggctcaag gtcaagtgca agggcatctg    300

aaaacccctg ggaactgaaa gtaatgtgag atcccgcact tgaccaccag ttcacacagc    360

cagtgttgcc caggagtcca gctcccttag ccacggtcct gagaactttc aaccagttga    420

ttttactgtg ataaaataga ataggggaaa tagatgaggg gtctggacac agaaagaaat    480

gaaaaaagca gatgaggctg agctaaaaag tacagttatg aagaaaatgt tggagaaaag    540

agaaaagatt agaaaccaat agtagaagaa agataataaa attacaacat gctcacacac    600

aggaatatta tgcagctgtt aaaagtcatg ctggtggcca ggtgtggtgg cacgtgccta    660

tagtctcacc tacctgggag gctgaggtgg gaggatcgct tg                       702


<210>  9463
<211>  77
<212>  PRT
<213>  Homosapiens

<400>  9463

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg 
65                  70                  75          


<210>  9464
<211>  2430
<212>  DNA
<213>  Homosapiens

<400>  9464
ggctttcggg tgctaggaga cagttgccgg cgttgggttg tgcgagacgc taactgtacc     60

ctccgggttt aacgctgtga ggcagcgcgc ggaggaactg gggataagcg ccccggagcc    120

cccaaacaga gcgcggccgc tgggggacag cgcgcggcgc cgggtcgggg cggggcggct    180

tttctgtcgg aggacgcgaa ccggcacgct gcgcctttaa ggagtccagc tgggctgggc    240

gccggagctg ggagcggcgc gggtaggagc ccggcggcag gtcccagccc ggggctagag    300

accgagggcc ggggtccggg cccggcggcg ggacccaggc ggttgaggct ggtcagaatc    360

tcattttcag cttctgccag agccagtagc agttgggaaa gaaggctgtg ctctttgaag    420

agagtcagcc agcctgaaag agcaggatgg atcttgatgt ggttaacatg tttgtgattg    480

cgggcggcac gctggccatc ccaatcctgg catttgtggc ttcatttctt ctgtggcctt    540

cagcactgat aagaatctat tattggtact ggcggaggac attgggcatg caagtccgct    600

atgttcacca tgaagactat cagttctgtt attccttccg gggcaggcct gggcacaaac    660

cctccatcct catgctccac ggattctctg cccacaagga tatgtggctc agtgtggtca    720

agttccttcc aaagaacctg cacttggtct gcgtggacat gccaggacat gagggcacca    780

cccgctcctc cctggatgac ctgtccatag atgggcaagt taagaggata caccagtttg    840

tagaatgcct gaagctgaac aaaaaacctt tccacctggt aggcacctcc atgggtggcc    900

aggtggctgg ggtgtatgct gcttactacc catcggatgt ctccagcctg tgtctcgtgt    960

gtcctgctgg cctgcagtac tcaactgaca atcaatttgt acaacggctc aaagaactgc   1020

agggctctgc cgccgtggag aagattccct tgatcccgtc taccccagaa gagatgagtg   1080

aaatgcttca gctctgctcc tatgtccgct tcaaggtgcc ccagcagatc ctgcaaggcc   1140

ttgtcgatgt ccgcatccct cataacaact tctaccgaaa gttgtttttg gaaatcgtca   1200

gtgagaagtc cagatactct ctccatcaga acatggacaa gatcaaggtt ccgacgcaga   1260

tcatctgggg gaaacaagac caggtgctgg atgtgtctgg ggcagacatg ttggccaagt   1320

caattgccaa ctgccaggtg gagcttctgg aaaactgtgg gcactcagta gtgatggaaa   1380

gacccaggaa gacagccaag ctcataatcg actttttagc ttctgtgcac aacacagaca   1440

acaacaagaa gctggactga ggccccgact gcagcctgca ttctgcacac agcatctgct   1500

cccatccccc aagtctgacg cagccaccac tctcagggat cctgccccaa atgcggtcgg   1560

agcgccagtg accctgagga agcccgtccc ttatccctgg tatccacggt tccccagagc   1620

tttggggacc acgcgaaaac ctccaagata tttttcacaa aatagaaact catatggaac   1680

aaaataagaa accccagcca tgaaatctac catgaagtct tcaagttcat gtcactgaga   1740

agcttgtgca aagcagccac cttggaccat aattaaatca aggacatttt ctttgagaca   1800

ttccttatag ttggagactc aagatatttt tgttgcatca ggtgtattcc cttgcatggg   1860

cagtggcttt tataggagca ttagtcctca ttcgctgaac cctgttgttt aggtctaatt   1920

taagttttac atagagaccc atgtatgact gcagcccatt ggctgcaaga ccagggagga   1980

aagtggcaag ctgtagaaaa tgtttacacg catggagggg cattgctcta gccctcagag   2040

cgtccggagc agcagggtac atgggtggga ggttcattca gcacccacca gtcaggtatg   2100

ttctgagtga acccacagca gtcgcagaat gagcacctgg cagggtgggt ttcctaggaa   2160

taatttatta tttttaaaaa taggcctaat aaagcaataa tgttctagac atctgtctaa   2220

gtaatcagac tcaggttcca cacacaagca acaactcgtg ggcctctttt ctatttcaat   2280

gtgctactaa gaacccttgg atgtaacata ctagttagtt aatgaattct gtgaattctg   2340

tgaagagtaa tgtgattgaa aataagtcta aacagctgta aaagtgacca caatgacatg   2400

aaataaattt aataagtcta gatcagcaac                                    2430


<210>  9465
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  9465

Met Asp Leu Asp Val Val Asn Met Phe Val Ile Ala Gly Gly Thr Leu 
1               5                   10                  15      


Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 
            20                  25                  30          


Ala Leu Ile Arg Ile Tyr Tyr Trp Tyr Trp Arg Arg Thr Leu Gly Met 
        35                  40                  45              


Gln Val Arg Tyr Val His His Glu Asp Tyr Gln Phe Cys Tyr Ser Phe 
    50                  55                  60                  


Arg Gly Arg Pro Gly His Lys Pro Ser Ile Leu Met Leu His Gly Phe 
65                  70                  75                  80  


Ser Ala His Lys Asp Met Trp Leu Ser Val Val Lys Phe Leu Pro Lys 
                85                  90                  95      


Asn Leu His Leu Val Cys Val Asp Met Pro Gly His Glu Gly Thr Thr 
            100                 105                 110         


Arg Ser Ser Leu Asp Asp Leu Ser Ile Asp Gly Gln Val Lys Arg Ile 
        115                 120                 125             


His Gln Phe Val Glu Cys Leu Lys Leu Asn Lys Lys Pro Phe His Leu 
    130                 135                 140                 


Val Gly Thr Ser Met Gly Gly Gln Val Ala Gly Val Tyr Ala Ala Tyr 
145                 150                 155                 160 


Tyr Pro Ser Asp Val Ser Ser Leu Cys Leu Val Cys Pro Ala Gly Leu 
                165                 170                 175     


Gln Tyr Ser Thr Asp Asn Gln Phe Val Gln Arg Leu Lys Glu Leu Gln 
            180                 185                 190         


Gly Ser Ala Ala Val Glu Lys Ile Pro Leu Ile Pro Ser Thr Pro Glu 
        195                 200                 205             


Glu Met Ser Glu Met Leu Gln Leu Cys Ser Tyr Val Arg Phe Lys Val 
    210                 215                 220                 


Pro Gln Gln Ile Leu Gln Gly Leu Val Asp Val Arg Ile Pro His Asn 
225                 230                 235                 240 


Asn Phe Tyr Arg Lys Leu Phe Leu Glu Ile Val Ser Glu Lys Ser Arg 
                245                 250                 255     


Tyr Ser Leu His Gln Asn Met Asp Lys Ile Lys Val Pro Thr Gln Ile 
            260                 265                 270         


Ile Trp Gly Lys Gln Asp Gln Val Leu Asp Val Ser Gly Ala Asp Met 
        275                 280                 285             


Leu Ala Lys Ser Ile Ala Asn Cys Gln Val Glu Leu Leu Glu Asn Cys 
    290                 295                 300                 


Gly His Ser Val Val Met Glu Arg Pro Arg Lys Thr Ala Lys Leu Ile 
305                 310                 315                 320 


Ile Asp Phe Leu Ala Ser Val His Asn Thr Asp Asn Asn Lys Lys Leu 
                325                 330                 335     


Asp 
    


<210>  9466
<211>  3099
<212>  DNA
<213>  Homosapiens

<400>  9466
ggctttcggg tgctaggaga cagttgccgg cgttgggttg tgcgagacgc taactgtacc     60

ctccgggttt aacgctgtga ggcagcgcgc ggaggaactg gggataagcg ccccggagcc    120

cccaaacaga gcgcggccgc tgggggacag cgcgcggcgc cgggtcgggg cggggcggct    180

tttctgtcgg aggacgcgaa ccggcacgct gcgcctttaa ggagtccagc tgggctgggc    240

gccggagctg ggagcggcgc gggtaggagc ccggcggcag gtcccagccc ggggctagag    300

accgagggcc ggggtccggg cccggcggcg ggacccaggc ggttgaggct ggtcagaatc    360

tcattttcag cttctgccag agccagtagc agttgggaaa gaaggctgtg ctctttgaag    420

agagtcagcc agcctgaaag agcaggatgg atcttgatgt ggttaacatg tttgtgattg    480

cgggcggcac gctggccatc ccaatcctgg catttgtggc ttcatttctt ctgtggcctt    540

cagcactgat aagaatctat tattggtact ggcggaggac attgggcatg caagtccgct    600

atgttcacca tgaagactat cagttctgtt attccttccg gggcaggcct gggcacaaac    660

cctccatcct catgctccac ggattctctg cccacaagga tatgtggctc agtgtggtca    720

agttccttcc aaagaacctg cacttggtct gcgtggacat gccaggacat gagggcacca    780

cccgctcctc cctggatgac ctgtccatag atgggcaagt taagaggata caccagtttg    840

tagaatgcct gaagctgaac aaaaaacctt tccacctggt aggcacctcc atgggtggcc    900

aggtggctgg ggtgtatgct gcttactacc catcggatgt ctccagcctg tgtctcgtgt    960

gtcctgctgg cctgcagtac tcaactgaca atcaatttgt acaacggctc aaagaactgc   1020

agggctctgc cgccgtggag aagattccct tgatcccgtc taccccagaa gagatgagtg   1080

aaatgcttca gctctgctcc tatgtccgct tcaaggtgcc ccagcagatc ctgcaaggcc   1140

ttgtcgatgt ccgcatccct cataacaact tctaccgaaa gttgtttttg gaaatcgtca   1200

gtgagaagtc cagatactct ctccatcaga acatggacaa gatcaaggtt ccgacgcaga   1260

tcatctgggg gaaacaagac caggtgctgg atgtgtctgg ggcagacatg ttggccaagt   1320

caattgccaa ctgccaggtg gagcttctgg aaaactgtgg gcactcagta gtgatggaaa   1380

gacccaggaa gacagccaag ctcataatcg actttttagc ttctgtgcac aacacagaca   1440

acaacaagaa gctggactga ggccccgact gcagcctgca ttctgcacac agcatctgct   1500

cccatccccc aagtctgacg cagccaccac tctcagggat cctgccccaa atgcggtcgg   1560

agcgccagtg accctgagga agcccgtccc ttatccctgg tatccacggt tccccagagc   1620

tttggggacc acgcgaaaac ctccaagata tttttcacaa aatagaaact catatggaac   1680

aaaataagaa accccagcca tgaaatctac catgaagtct tcaagttcat gtcactgaga   1740

agcttgtgca aagcagccac cttggaccat aattaaatca aggacatttt ctttgagaca   1800

ttccttatag ttggagactc aagatatttt tgttgcatca ggtgtattcc cttgcatggg   1860

cagtggcttt tataggagca ttagtcctca ttcgctgaac cctgttgttt aggtctaatt   1920

taagttttac atagagaccc atgtatgact gcagcccatt ggctgcaaga ccagggagga   1980

aagtggcaag ctgtagaaaa tgtttacacg catggagggg cattgctcta gccctcagag   2040

cgtccggagc agcagggtac atgggtggga ggttcattca gcacccacca gtcaggtatg   2100

ttctgagtga acccacagca gtcgcagaat gagcacctgg cagggtgggt ttcctaggaa   2160

taatttatta tttttaaaaa taggcctaat aaagcaataa tgttctagac atctgtctaa   2220

gtaatcagac tcaggttcca cacacaagca acaactcgtg ggcctctttt ctatttcaat   2280

gtgctactaa gaacccttgg atgtaacata ctagttagtt aatgaattct gtgaattctg   2340

tgaagagtaa tgtgattgaa aataagtcta aacagctgta aaagtgacca caatgacatg   2400

aaataaattt aataagtcta gatcagcaac atgcaggtgg tttctatttc tgaactccta   2460

attaggtgca atgttggcag attttctgtt aactttaaaa tgtgtttttt aaaataaggc   2520

ttgtttaaca ggctttggaa gtctttgcat ggatgattta ttaggtttaa ggaatcatgt   2580

ttgcaatttt tatccagttg aaattgtata tcaaaggcca ggtgcagtgg ctcatgcctg   2640

taatcccagc acttgagaag gccgaggtgg gtcgattgct tgaggccagg agttcaagac   2700

caacctggcc aacatggcaa aatcttatct ctactaaaaa tgcaaaaatt atctgggcgt   2760

ggtgggacac acctgtaatc ccagctacct gggagcctga ggcatgagaa tcgcttgaac   2820

ccgggaggcg gaggttacag tgagccgaga ttgtgccatt gcactccagc ctgggcaata   2880

agcgcaaaaa tccatctcaa aataatataa taataattca ctggaaattg tatatcaaaa   2940

aaggcaagag tcatcaaaat attctttttg actctttctg taggatttag gagccctaaa   3000

ctccccagga gcttcactct ttccaatttt ttttttacag aaaatctaca gccaagtcat   3060

tctgggaata aagtgagata aactttacag tttaaatct                          3099


<210>  9467
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  9467

Met Asp Leu Asp Val Val Asn Met Phe Val Ile Ala Gly Gly Thr Leu 
1               5                   10                  15      


Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 
            20                  25                  30          


Ala Leu Ile Arg Ile Tyr Tyr Trp Tyr Trp Arg Arg Thr Leu Gly Met 
        35                  40                  45              


Gln Val Arg Tyr Val His His Glu Asp Tyr Gln Phe Cys Tyr Ser Phe 
    50                  55                  60                  


Arg Gly Arg Pro Gly His Lys Pro Ser Ile Leu Met Leu His Gly Phe 
65                  70                  75                  80  


Ser Ala His Lys Asp Met Trp Leu Ser Val Val Lys Phe Leu Pro Lys 
                85                  90                  95      


Asn Leu His Leu Val Cys Val Asp Met Pro Gly His Glu Gly Thr Thr 
            100                 105                 110         


Arg Ser Ser Leu Asp Asp Leu Ser Ile Asp Gly Gln Val Lys Arg Ile 
        115                 120                 125             


His Gln Phe Val Glu Cys Leu Lys Leu Asn Lys Lys Pro Phe His Leu 
    130                 135                 140                 


Val Gly Thr Ser Met Gly Gly Gln Val Ala Gly Val Tyr Ala Ala Tyr 
145                 150                 155                 160 


Tyr Pro Ser Asp Val Ser Ser Leu Cys Leu Val Cys Pro Ala Gly Leu 
                165                 170                 175     


Gln Tyr Ser Thr Asp Asn Gln Phe Val Gln Arg Leu Lys Glu Leu Gln 
            180                 185                 190         


Gly Ser Ala Ala Val Glu Lys Ile Pro Leu Ile Pro Ser Thr Pro Glu 
        195                 200                 205             


Glu Met Ser Glu Met Leu Gln Leu Cys Ser Tyr Val Arg Phe Lys Val 
    210                 215                 220                 


Pro Gln Gln Ile Leu Gln Gly Leu Val Asp Val Arg Ile Pro His Asn 
225                 230                 235                 240 


Asn Phe Tyr Arg Lys Leu Phe Leu Glu Ile Val Ser Glu Lys Ser Arg 
                245                 250                 255     


Tyr Ser Leu His Gln Asn Met Asp Lys Ile Lys Val Pro Thr Gln Ile 
            260                 265                 270         


Ile Trp Gly Lys Gln Asp Gln Val Leu Asp Val Ser Gly Ala Asp Met 
        275                 280                 285             


Leu Ala Lys Ser Ile Ala Asn Cys Gln Val Glu Leu Leu Glu Asn Cys 
    290                 295                 300                 


Gly His Ser Val Val Met Glu Arg Pro Arg Lys Thr Ala Lys Leu Ile 
305                 310                 315                 320 


Ile Asp Phe Leu Ala Ser Val His Asn Thr Asp Asn Asn Lys Lys Leu 
                325                 330                 335     


Asp 
    


<210>  9468
<211>  2224
<212>  DNA
<213>  Homosapiens

<400>  9468
gccgggtcgg ggcggggcgg cttttctgtc ggaggacgcg aaccggcacg ctgcgccttt     60

aaggagtcca gctgggctgg gcgccggagc tgggagcggc gcgggtagga gcccggcggc    120

aggtcccagc ccggggctag agaccgaggg ccggggtccg ggcccggcgg cgggacccag    180

gcggttgagg ctggtcagaa tctcattttc agcaggagtc agccagcctg aaagagcagg    240

atggatcttg atgtggttaa catgtttgtg attgcgggcg gcacgctggc catcccaatc    300

ctggcatttg tggcttcatt tcttctgtgg ccttcagcac tgataagaat ctattattgg    360

tactggcgga ggacattggg catgcaagtc cgctatgttc accatgaaga ctatcagttc    420

tgttattcct tccggggcag gcctgggcac aaaccctcca tcctcatgct ccacggattc    480

tctgcccaca aggatatgtg gctcagtgtg gtcaagttcc ttccaaagaa cctgcacttg    540

gtctgcgtgg acatgccagg acatgagggc accacccgct cctccctgga tgacctgtcc    600

atagatgggc aagttaagag gatacaccag tttgtagaat gcctgaagct gaacaaaaaa    660

cctttccacc tggtaggcac ctccatgggt ggccaggtgg ctggggtgta tgctgcttac    720

tacccatcgg atgtctccag cctgtgtctc gtgtgtcctg ctggcctgca gtactcaact    780

gacaatcaat ttgtacaacg gctcaaagaa ctgcagggct ctgccgccgt ggagaagatt    840

cccttgatcc cgtctacccc agaagagatg agtgaaatgc ttcagctctg ctcctatgtc    900

cgcttcaagg tgccccagca gatcctgcaa ggccttgtcg atgtccgcat ccctcataac    960

aacttctacc gaaagttgtt tttggaaatc gtcagtgaga agtccagata ctctctccat   1020

cagaacatgg acaagatcaa ggttccgacg cagatcatct gggggaaaca agaccaggtg   1080

ctggatgtgt ctggggcaga catgttggcc aagtcaattg ccaactgcca ggtggagctt   1140

ctggaaaact gtgggcactc agtagtgatg gaaagaccca ggaagacagc caagctcata   1200

atcgactttt tagcttctgt gcacaacaca gacaacaaca agaagctgga ctgaggcccc   1260

gactgcagcc tgcattctgc acacagcatc tgctcccatc ccccaagtct gacgcagcca   1320

ccactctcag ggatcctgcc ccaaatgcgg tcggagcgcc agtgaccctg aggaagcccg   1380

tcccttatcc ctggtatcca cggttcccca gagctttggg gaccacgcga aaacctccaa   1440

gatatttttc acaaaataga aactcatatg gaacaaaata agaaacccca gccatgaaat   1500

ctaccatgaa gtcttcaagt tcatgtcact gagaagcttg tgcaaagcag ccaccttgga   1560

ccataattaa atcaaggaca ttttctttga gacattcctt atagttggag actcaagata   1620

tttttgttgc atcaggtgta ttcccttgca tgggcagtgg cttttatagg agcattagtc   1680

ctcattcgct gaaccctgtt gtttaggtct aatttaagtt ttacatagag acccatgtat   1740

gactgcagcc cattggctgc aagaccaggg aggaaagtgg caagctgtag aaaatgttta   1800

cacgcatgga ggggcattgc tctagccctc agagcgtccg gagcagcagg gtacatgggt   1860

gggaggttca ttcagcaccc accagtcagg tatgttctga gtgaacccac agcagtcgca   1920

gaatgagcac ctggcagggt gggtttccta ggaataattt attattttta aaaataggcc   1980

taataaagca ataatgttct agacatctgt ctaagtaatc agactcaggt tccacacaca   2040

agcaacaact cgtgggcctc ttttctattt caatgtgcta ctaagaaccc ttggatgtaa   2100

catactagtt agttaatgaa ttctgtgaat tctgtgaaga gtaatgtgat tgaaaataag   2160

tctaaacagc tgtaaaagtg accacaatga catgaaataa atttaataag tctagatcag   2220

caac                                                                2224


<210>  9469
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  9469

Met Asp Leu Asp Val Val Asn Met Phe Val Ile Ala Gly Gly Thr Leu 
1               5                   10                  15      


Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 
            20                  25                  30          


Ala Leu Ile Arg Ile Tyr Tyr Trp Tyr Trp Arg Arg Thr Leu Gly Met 
        35                  40                  45              


Gln Val Arg Tyr Val His His Glu Asp Tyr Gln Phe Cys Tyr Ser Phe 
    50                  55                  60                  


Arg Gly Arg Pro Gly His Lys Pro Ser Ile Leu Met Leu His Gly Phe 
65                  70                  75                  80  


Ser Ala His Lys Asp Met Trp Leu Ser Val Val Lys Phe Leu Pro Lys 
                85                  90                  95      


Asn Leu His Leu Val Cys Val Asp Met Pro Gly His Glu Gly Thr Thr 
            100                 105                 110         


Arg Ser Ser Leu Asp Asp Leu Ser Ile Asp Gly Gln Val Lys Arg Ile 
        115                 120                 125             


His Gln Phe Val Glu Cys Leu Lys Leu Asn Lys Lys Pro Phe His Leu 
    130                 135                 140                 


Val Gly Thr Ser Met Gly Gly Gln Val Ala Gly Val Tyr Ala Ala Tyr 
145                 150                 155                 160 


Tyr Pro Ser Asp Val Ser Ser Leu Cys Leu Val Cys Pro Ala Gly Leu 
                165                 170                 175     


Gln Tyr Ser Thr Asp Asn Gln Phe Val Gln Arg Leu Lys Glu Leu Gln 
            180                 185                 190         


Gly Ser Ala Ala Val Glu Lys Ile Pro Leu Ile Pro Ser Thr Pro Glu 
        195                 200                 205             


Glu Met Ser Glu Met Leu Gln Leu Cys Ser Tyr Val Arg Phe Lys Val 
    210                 215                 220                 


Pro Gln Gln Ile Leu Gln Gly Leu Val Asp Val Arg Ile Pro His Asn 
225                 230                 235                 240 


Asn Phe Tyr Arg Lys Leu Phe Leu Glu Ile Val Ser Glu Lys Ser Arg 
                245                 250                 255     


Tyr Ser Leu His Gln Asn Met Asp Lys Ile Lys Val Pro Thr Gln Ile 
            260                 265                 270         


Ile Trp Gly Lys Gln Asp Gln Val Leu Asp Val Ser Gly Ala Asp Met 
        275                 280                 285             


Leu Ala Lys Ser Ile Ala Asn Cys Gln Val Glu Leu Leu Glu Asn Cys 
    290                 295                 300                 


Gly His Ser Val Val Met Glu Arg Pro Arg Lys Thr Ala Lys Leu Ile 
305                 310                 315                 320 


Ile Asp Phe Leu Ala Ser Val His Asn Thr Asp Asn Asn Lys Lys Leu 
                325                 330                 335     


Asp 
    


<210>  9470
<211>  2893
<212>  DNA
<213>  Homosapiens

<400>  9470
gccgggtcgg ggcggggcgg cttttctgtc ggaggacgcg aaccggcacg ctgcgccttt     60

aaggagtcca gctgggctgg gcgccggagc tgggagcggc gcgggtagga gcccggcggc    120

aggtcccagc ccggggctag agaccgaggg ccggggtccg ggcccggcgg cgggacccag    180

gcggttgagg ctggtcagaa tctcattttc agcaggagtc agccagcctg aaagagcagg    240

atggatcttg atgtggttaa catgtttgtg attgcgggcg gcacgctggc catcccaatc    300

ctggcatttg tggcttcatt tcttctgtgg ccttcagcac tgataagaat ctattattgg    360

tactggcgga ggacattggg catgcaagtc cgctatgttc accatgaaga ctatcagttc    420

tgttattcct tccggggcag gcctgggcac aaaccctcca tcctcatgct ccacggattc    480

tctgcccaca aggatatgtg gctcagtgtg gtcaagttcc ttccaaagaa cctgcacttg    540

gtctgcgtgg acatgccagg acatgagggc accacccgct cctccctgga tgacctgtcc    600

atagatgggc aagttaagag gatacaccag tttgtagaat gcctgaagct gaacaaaaaa    660

cctttccacc tggtaggcac ctccatgggt ggccaggtgg ctggggtgta tgctgcttac    720

tacccatcgg atgtctccag cctgtgtctc gtgtgtcctg ctggcctgca gtactcaact    780

gacaatcaat ttgtacaacg gctcaaagaa ctgcagggct ctgccgccgt ggagaagatt    840

cccttgatcc cgtctacccc agaagagatg agtgaaatgc ttcagctctg ctcctatgtc    900

cgcttcaagg tgccccagca gatcctgcaa ggccttgtcg atgtccgcat ccctcataac    960

aacttctacc gaaagttgtt tttggaaatc gtcagtgaga agtccagata ctctctccat   1020

cagaacatgg acaagatcaa ggttccgacg cagatcatct gggggaaaca agaccaggtg   1080

ctggatgtgt ctggggcaga catgttggcc aagtcaattg ccaactgcca ggtggagctt   1140

ctggaaaact gtgggcactc agtagtgatg gaaagaccca ggaagacagc caagctcata   1200

atcgactttt tagcttctgt gcacaacaca gacaacaaca agaagctgga ctgaggcccc   1260

gactgcagcc tgcattctgc acacagcatc tgctcccatc ccccaagtct gacgcagcca   1320

ccactctcag ggatcctgcc ccaaatgcgg tcggagcgcc agtgaccctg aggaagcccg   1380

tcccttatcc ctggtatcca cggttcccca gagctttggg gaccacgcga aaacctccaa   1440

gatatttttc acaaaataga aactcatatg gaacaaaata agaaacccca gccatgaaat   1500

ctaccatgaa gtcttcaagt tcatgtcact gagaagcttg tgcaaagcag ccaccttgga   1560

ccataattaa atcaaggaca ttttctttga gacattcctt atagttggag actcaagata   1620

tttttgttgc atcaggtgta ttcccttgca tgggcagtgg cttttatagg agcattagtc   1680

ctcattcgct gaaccctgtt gtttaggtct aatttaagtt ttacatagag acccatgtat   1740

gactgcagcc cattggctgc aagaccaggg aggaaagtgg caagctgtag aaaatgttta   1800

cacgcatgga ggggcattgc tctagccctc agagcgtccg gagcagcagg gtacatgggt   1860

gggaggttca ttcagcaccc accagtcagg tatgttctga gtgaacccac agcagtcgca   1920

gaatgagcac ctggcagggt gggtttccta ggaataattt attattttta aaaataggcc   1980

taataaagca ataatgttct agacatctgt ctaagtaatc agactcaggt tccacacaca   2040

agcaacaact cgtgggcctc ttttctattt caatgtgcta ctaagaaccc ttggatgtaa   2100

catactagtt agttaatgaa ttctgtgaat tctgtgaaga gtaatgtgat tgaaaataag   2160

tctaaacagc tgtaaaagtg accacaatga catgaaataa atttaataag tctagatcag   2220

caacatgcag gtggtttcta tttctgaact cctaattagg tgcaatgttg gcagattttc   2280

tgttaacttt aaaatgtgtt ttttaaaata aggcttgttt aacaggcttt ggaagtcttt   2340

gcatggatga tttattaggt ttaaggaatc atgtttgcaa tttttatcca gttgaaattg   2400

tatatcaaag gccaggtgca gtggctcatg cctgtaatcc cagcacttga gaaggccgag   2460

gtgggtcgat tgcttgaggc caggagttca agaccaacct ggccaacatg gcaaaatctt   2520

atctctacta aaaatgcaaa aattatctgg gcgtggtggg acacacctgt aatcccagct   2580

acctgggagc ctgaggcatg agaatcgctt gaacccggga ggcggaggtt acagtgagcc   2640

gagattgtgc cattgcactc cagcctgggc aataagcgca aaaatccatc tcaaaataat   2700

ataataataa ttcactggaa attgtatatc aaaaaaggca agagtcatca aaatattctt   2760

tttgactctt tctgtaggat ttaggagccc taaactcccc aggagcttca ctctttccaa   2820

tttttttttt acagaaaatc tacagccaag tcattctggg aataaagtga gataaacttt   2880

acagtttaaa tct                                                      2893


<210>  9471
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  9471

Met Asp Leu Asp Val Val Asn Met Phe Val Ile Ala Gly Gly Thr Leu 
1               5                   10                  15      


Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 
            20                  25                  30          


Ala Leu Ile Arg Ile Tyr Tyr Trp Tyr Trp Arg Arg Thr Leu Gly Met 
        35                  40                  45              


Gln Val Arg Tyr Val His His Glu Asp Tyr Gln Phe Cys Tyr Ser Phe 
    50                  55                  60                  


Arg Gly Arg Pro Gly His Lys Pro Ser Ile Leu Met Leu His Gly Phe 
65                  70                  75                  80  


Ser Ala His Lys Asp Met Trp Leu Ser Val Val Lys Phe Leu Pro Lys 
                85                  90                  95      


Asn Leu His Leu Val Cys Val Asp Met Pro Gly His Glu Gly Thr Thr 
            100                 105                 110         


Arg Ser Ser Leu Asp Asp Leu Ser Ile Asp Gly Gln Val Lys Arg Ile 
        115                 120                 125             


His Gln Phe Val Glu Cys Leu Lys Leu Asn Lys Lys Pro Phe His Leu 
    130                 135                 140                 


Val Gly Thr Ser Met Gly Gly Gln Val Ala Gly Val Tyr Ala Ala Tyr 
145                 150                 155                 160 


Tyr Pro Ser Asp Val Ser Ser Leu Cys Leu Val Cys Pro Ala Gly Leu 
                165                 170                 175     


Gln Tyr Ser Thr Asp Asn Gln Phe Val Gln Arg Leu Lys Glu Leu Gln 
            180                 185                 190         


Gly Ser Ala Ala Val Glu Lys Ile Pro Leu Ile Pro Ser Thr Pro Glu 
        195                 200                 205             


Glu Met Ser Glu Met Leu Gln Leu Cys Ser Tyr Val Arg Phe Lys Val 
    210                 215                 220                 


Pro Gln Gln Ile Leu Gln Gly Leu Val Asp Val Arg Ile Pro His Asn 
225                 230                 235                 240 


Asn Phe Tyr Arg Lys Leu Phe Leu Glu Ile Val Ser Glu Lys Ser Arg 
                245                 250                 255     


Tyr Ser Leu His Gln Asn Met Asp Lys Ile Lys Val Pro Thr Gln Ile 
            260                 265                 270         


Ile Trp Gly Lys Gln Asp Gln Val Leu Asp Val Ser Gly Ala Asp Met 
        275                 280                 285             


Leu Ala Lys Ser Ile Ala Asn Cys Gln Val Glu Leu Leu Glu Asn Cys 
    290                 295                 300                 


Gly His Ser Val Val Met Glu Arg Pro Arg Lys Thr Ala Lys Leu Ile 
305                 310                 315                 320 


Ile Asp Phe Leu Ala Ser Val His Asn Thr Asp Asn Asn Lys Lys Leu 
                325                 330                 335     


Asp 
    


<210>  9472
<211>  2145
<212>  DNA
<213>  Homosapiens

<400>  9472
ggagtccagc tgggctgggc gccggagctg ggagcggcgc gggtaggagc ccggcggcag     60

gtcccagccc ggggctagag accgagggcc ggggtccggg cccggcggcg ggacccaggc    120

ggttgaggct ggtcaggagt cagccagcct gaaagagcag gatggatctt gatgtggtta    180

acatgtttgt gattgcgggc ggcacgctgg ccatcccaat cctggcattt gtggcttcat    240

ttcttctgtg gccttcagca ctgataagaa tctattattg gtactggcgg aggacattgg    300

gcatgcaagt ccgctatgtt caccatgaag actatcagtt ctgttattcc ttccggggca    360

ggcctgggca caaaccctcc atcctcatgc tccacggatt ctctgcccac aaggatatgt    420

ggctcagtgt ggtcaagttc cttccaaaga acctgcactt ggtctgcgtg gacatgccag    480

gacatgaggg caccacccgc tcctccctgg atgacctgtc catagatggg caagttaaga    540

ggatacacca gtttgtagaa tgcctgaagc tgaacaaaaa acctttccac ctggtaggca    600

cctccatggg tggccaggtg gctggggtgt atgctgctta ctacccatcg gatgtctcca    660

gcctgtgtct cgtgtgtcct gctggcctgc agtactcaac tgacaatcaa tttgtacaac    720

ggctcaaaga actgcagggc tctgccgccg tggagaagat tcccttgatc ccgtctaccc    780

cagaagagat gagtgaaatg cttcagctct gctcctatgt ccgcttcaag gtgccccagc    840

agatcctgca aggccttgtc gatgtccgca tccctcataa caacttctac cgaaagttgt    900

ttttggaaat cgtcagtgag aagtccagat actctctcca tcagaacatg gacaagatca    960

aggttccgac gcagatcatc tgggggaaac aagaccaggt gctggatgtg tctggggcag   1020

acatgttggc caagtcaatt gccaactgcc aggtggagct tctggaaaac tgtgggcact   1080

cagtagtgat ggaaagaccc aggaagacag ccaagctcat aatcgacttt ttagcttctg   1140

tgcacaacac agacaacaac aagaagctgg actgaggccc cgactgcagc ctgcattctg   1200

cacacagcat ctgctcccat cccccaagtc tgacgcagcc accactctca gggatcctgc   1260

cccaaatgcg gtcggagcgc cagtgaccct gaggaagccc gtcccttatc cctggtatcc   1320

acggttcccc agagctttgg ggaccacgcg aaaacctcca agatattttt cacaaaatag   1380

aaactcatat ggaacaaaat aagaaacccc agccatgaaa tctaccatga agtcttcaag   1440

ttcatgtcac tgagaagctt gtgcaaagca gccaccttgg accataatta aatcaaggac   1500

attttctttg agacattcct tatagttgga gactcaagat atttttgttg catcaggtgt   1560

attcccttgc atgggcagtg gcttttatag gagcattagt cctcattcgc tgaaccctgt   1620

tgtttaggtc taatttaagt tttacataga gacccatgta tgactgcagc ccattggctg   1680

caagaccagg gaggaaagtg gcaagctgta gaaaatgttt acacgcatgg aggggcattg   1740

ctctagccct cagagcgtcc ggagcagcag ggtacatggg tgggaggttc attcagcacc   1800

caccagtcag gtatgttctg agtgaaccca cagcagtcgc agaatgagca cctggcaggg   1860

tgggtttcct aggaataatt tattattttt aaaaataggc ctaataaagc aataatgttc   1920

tagacatctg tctaagtaat cagactcagg ttccacacac aagcaacaac tcgtgggcct   1980

cttttctatt tcaatgtgct actaagaacc cttggatgta acatactagt tagttaatga   2040

attctgtgaa ttctgtgaag agtaatgtga ttgaaaataa gtctaaacag ctgtaaaagt   2100

gaccacaatg acatgaaata aatttaataa gtctagatca gcaac                   2145


<210>  9473
<211>  337
<212>  PRT
<213>  Homosapiens

<400>  9473

Met Asp Leu Asp Val Val Asn Met Phe Val Ile Ala Gly Gly Thr Leu 
1               5                   10                  15      


Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 
            20                  25                  30          


Ala Leu Ile Arg Ile Tyr Tyr Trp Tyr Trp Arg Arg Thr Leu Gly Met 
        35                  40                  45              


Gln Val Arg Tyr Val His His Glu Asp Tyr Gln Phe Cys Tyr Ser Phe 
    50                  55                  60                  


Arg Gly Arg Pro Gly His Lys Pro Ser Ile Leu Met Leu His Gly Phe 
65                  70                  75                  80  


Ser Ala His Lys Asp Met Trp Leu Ser Val Val Lys Phe Leu Pro Lys 
                85                  90                  95      


Asn Leu His Leu Val Cys Val Asp Met Pro Gly His Glu Gly Thr Thr 
            100                 105                 110         


Arg Ser Ser Leu Asp Asp Leu Ser Ile Asp Gly Gln Val Lys Arg Ile 
        115                 120                 125             


His Gln Phe Val Glu Cys Leu Lys Leu Asn Lys Lys Pro Phe His Leu 
    130                 135                 140                 


Val Gly Thr Ser Met Gly Gly Gln Val Ala Gly Val Tyr Ala Ala Tyr 
145                 150                 155                 160 


Tyr Pro Ser Asp Val Ser Ser Leu Cys Leu Val Cys Pro Ala Gly Leu 
                165                 170                 175     


Gln Tyr Ser Thr Asp Asn Gln Phe Val Gln Arg Leu Lys Glu Leu Gln 
            180                 185                 190         


Gly Ser Ala Ala Val Glu Lys Ile Pro Leu Ile Pro Ser Thr Pro Glu 
        195                 200                 205             


Glu Met Ser Glu Met Leu Gln Leu Cys Ser Tyr Val Arg Phe Lys Val 
    210                 215                 220                 


Pro Gln Gln Ile Leu Gln Gly Leu Val Asp Val Arg Ile Pro His Asn 
225                 230                 235                 240 


Asn Phe Tyr Arg Lys Leu Phe Leu Glu Ile Val Ser Glu Lys Ser Arg 
                245                 250                 255     


Tyr Ser Leu His Gln Asn Met Asp Lys Ile Lys Val Pro Thr Gln Ile 
            260                 265                 270         


Ile Trp Gly Lys Gln Asp Gln Val Leu Asp Val Ser Gly Ala Asp Met 
        275                 280                 285             


Leu Ala Lys Ser Ile Ala Asn Cys Gln Val Glu Leu Leu Glu Asn Cys 
    290                 295                 300                 


Gly His Ser Val Val Met Glu Arg Pro Arg Lys Thr Ala Lys Leu Ile 
305                 310                 315                 320 


Ile Asp Phe Leu Ala Ser Val His Asn Thr Asp Asn Asn Lys Lys Leu 
                325                 330                 335     


Asp 
    


<210>  9474
<211>  1404
<212>  DNA
<213>  Homosapiens

<400>  9474
ggcttttatt tcttaaatct ctgacacttt gaatgtctct ttgggcccct gaagagagga     60

agtggtggcc tggatctggt gactatccct tgattctgcg gtggtgccac aggcacagtc    120

cagcacatac tcactttgtt ttccttttct gacaagtgtt tttggaaatc gtcagtgaga    180

agtccagata ctctctccat cagaacatgg acaagatcaa ggttccgacg cagatcatct    240

gggggaaaca agaccaggtg ctggatgtgt ctggggcaga catgttggcc aagtcaattg    300

ccaactgcca ggtggagctt ctggaaaact gtgggcactc agtagtgatg gaaagaccca    360

ggaagacagc caagctcata atcgactttt tagcttctgt gcacaacaca gacaacaaca    420

agaagctgga ctgaggcccc gactgcagcc tgcattctgc acacagcatc tgctcccatc    480

ccccaagtct gacgcagcca ccactctcag ggatcctgcc ccaaatgcgg tcggagcgcc    540

agtgaccctg aggaagcccg tcccttatcc ctggtatcca cggttcccca gagctttggg    600

gaccacgcga aaacctccaa gatatttttc acaaaataga aactcatatg gaacaaaata    660

agaaacccca gccatgaaat ctaccatgaa gtcttcaagt tcatgtcact gagaagcttg    720

tgcaaagcag ccaccttgga ccataattaa atcaaggaca ttttctttga gacattcctt    780

atagttggag actcaagata tttttgttgc atcaggtgta ttcccttgca tgggcagtgg    840

cttttatagg agcattagtc ctcattcgct gaaccctgtt gtttaggtct aatttaagtt    900

ttacatagag acccatgtat gactgcagcc cattggctgc aagaccaggg aggaaagtgg    960

caagctgtag aaaatgttta cacgcatgga ggggcattgc tctagccctc agagcgtccg   1020

gagcagcagg gtacatgggt gggaggttca ttcagcaccc accagtcagg tatgttctga   1080

gtgaacccac agcagtcgca gaatgagcac ctggcagggt gggtttccta ggaataattt   1140

attattttta aaaataggcc taataaagca ataatgttct agacatctgt ctaagtaatc   1200

agactcaggt tccacacaca agcaacaact cgtgggcctc ttttctattt caatgtgcta   1260

ctaagaaccc ttggatgtaa catactagtt agttaatgaa ttctgtgaat tctgtgaaga   1320

gtaatgtgat tgaaaataag tctaaacagc tgtaaaagtg accacaatga catgaaataa   1380

atttaataag tctagatcag caac                                          1404


<210>  9475
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  9475

Met Asp Lys Ile Lys Val Pro Thr Gln Ile Ile Trp Gly Lys Gln Asp 
1               5                   10                  15      


Gln Val Leu Asp Val Ser Gly Ala Asp Met Leu Ala Lys Ser Ile Ala 
            20                  25                  30          


Asn Cys Gln Val Glu Leu Leu Glu Asn Cys Gly His Ser Val Val Met 
        35                  40                  45              


Glu Arg Pro Arg Lys Thr Ala Lys Leu Ile Ile Asp Phe Leu Ala Ser 
    50                  55                  60                  


Val His Asn Thr Asp Asn Asn Lys Lys Leu Asp 
65                  70                  75  


<210>  9476
<211>  2073
<212>  DNA
<213>  Homosapiens

<400>  9476
ggcttttatt tcttaaatct ctgacacttt gaatgtctct ttgggcccct gaagagagga     60

agtggtggcc tggatctggt gactatccct tgattctgcg gtggtgccac aggcacagtc    120

cagcacatac tcactttgtt ttccttttct gacaagtgtt tttggaaatc gtcagtgaga    180

agtccagata ctctctccat cagaacatgg acaagatcaa ggttccgacg cagatcatct    240

gggggaaaca agaccaggtg ctggatgtgt ctggggcaga catgttggcc aagtcaattg    300

ccaactgcca ggtggagctt ctggaaaact gtgggcactc agtagtgatg gaaagaccca    360

ggaagacagc caagctcata atcgactttt tagcttctgt gcacaacaca gacaacaaca    420

agaagctgga ctgaggcccc gactgcagcc tgcattctgc acacagcatc tgctcccatc    480

ccccaagtct gacgcagcca ccactctcag ggatcctgcc ccaaatgcgg tcggagcgcc    540

agtgaccctg aggaagcccg tcccttatcc ctggtatcca cggttcccca gagctttggg    600

gaccacgcga aaacctccaa gatatttttc acaaaataga aactcatatg gaacaaaata    660

agaaacccca gccatgaaat ctaccatgaa gtcttcaagt tcatgtcact gagaagcttg    720

tgcaaagcag ccaccttgga ccataattaa atcaaggaca ttttctttga gacattcctt    780

atagttggag actcaagata tttttgttgc atcaggtgta ttcccttgca tgggcagtgg    840

cttttatagg agcattagtc ctcattcgct gaaccctgtt gtttaggtct aatttaagtt    900

ttacatagag acccatgtat gactgcagcc cattggctgc aagaccaggg aggaaagtgg    960

caagctgtag aaaatgttta cacgcatgga ggggcattgc tctagccctc agagcgtccg   1020

gagcagcagg gtacatgggt gggaggttca ttcagcaccc accagtcagg tatgttctga   1080

gtgaacccac agcagtcgca gaatgagcac ctggcagggt gggtttccta ggaataattt   1140

attattttta aaaataggcc taataaagca ataatgttct agacatctgt ctaagtaatc   1200

agactcaggt tccacacaca agcaacaact cgtgggcctc ttttctattt caatgtgcta   1260

ctaagaaccc ttggatgtaa catactagtt agttaatgaa ttctgtgaat tctgtgaaga   1320

gtaatgtgat tgaaaataag tctaaacagc tgtaaaagtg accacaatga catgaaataa   1380

atttaataag tctagatcag caacatgcag gtggtttcta tttctgaact cctaattagg   1440

tgcaatgttg gcagattttc tgttaacttt aaaatgtgtt ttttaaaata aggcttgttt   1500

aacaggcttt ggaagtcttt gcatggatga tttattaggt ttaaggaatc atgtttgcaa   1560

tttttatcca gttgaaattg tatatcaaag gccaggtgca gtggctcatg cctgtaatcc   1620

cagcacttga gaaggccgag gtgggtcgat tgcttgaggc caggagttca agaccaacct   1680

ggccaacatg gcaaaatctt atctctacta aaaatgcaaa aattatctgg gcgtggtggg   1740

acacacctgt aatcccagct acctgggagc ctgaggcatg agaatcgctt gaacccggga   1800

ggcggaggtt acagtgagcc gagattgtgc cattgcactc cagcctgggc aataagcgca   1860

aaaatccatc tcaaaataat ataataataa ttcactggaa attgtatatc aaaaaaggca   1920

agagtcatca aaatattctt tttgactctt tctgtaggat ttaggagccc taaactcccc   1980

aggagcttca ctctttccaa tttttttttt acagaaaatc tacagccaag tcattctggg   2040

aataaagtga gataaacttt acagtttaaa tct                                2073


<210>  9477
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  9477

Met Asp Lys Ile Lys Val Pro Thr Gln Ile Ile Trp Gly Lys Gln Asp 
1               5                   10                  15      


Gln Val Leu Asp Val Ser Gly Ala Asp Met Leu Ala Lys Ser Ile Ala 
            20                  25                  30          


Asn Cys Gln Val Glu Leu Leu Glu Asn Cys Gly His Ser Val Val Met 
        35                  40                  45              


Glu Arg Pro Arg Lys Thr Ala Lys Leu Ile Ile Asp Phe Leu Ala Ser 
    50                  55                  60                  


Val His Asn Thr Asp Asn Asn Lys Lys Leu Asp 
65                  70                  75  


<210>  9478
<211>  2083
<212>  DNA
<213>  Homosapiens

<400>  9478
atttgagttg gtgagaatag agcaaagaca cagaaggtgc ttgagtttgt tggggctttt     60

gcttttgccg ttaaggatgg ggaggagggg ccctcttgtc taggatgaat tgaaggtaaa    120

ggcagctaag agaaggggag tgaatgcgga tccacttctg agggaggatg ttggggaaaa    180

agatggaggt ggattggcat agtagctggg aacccagagg aaaaggagag gaaatgagtt    240

gtttgaaaag gatcagccct ggaaaagttc tggctttcat gttggaaaag cattccccat    300

atctgcagag gttagagcca agaaacacac agctctgggg atccccagag gaccttcaaa    360

gagacctcca gctgggtgcg gtggctcagg cctgtaatcc tagcactttg ggaggctgag    420

gcaggtggat cacctgaggt caggagttcg agaccagcct ggccaacgtg gtgaaacccc    480

atctctacta gaaatacaaa aattagctgg gcatggtggc gggcacctat aatcccagct    540

actggggagg ctgaggcaga agatcacttg aacctgggag gcggaggttg cagtgagttg    600

agatcacgcc acttcattcc agcctgggcg aaagagtgaa actccttttc aacaaataaa    660

gagatacccc cagcttgtga taattagcct tcccctcttg catccttcct acagcttggg    720

ctgccctaac cagccacagg gccagcctga tcaagtcact caccttaaca cagcctgtgg    780

ttccccatgg tccgtgtggc tgtaggagca gcgccctcct ctctgcccct tctccccacc    840

atgccacccc cactgcccat gtgcttggtg tctcagccgc cgtgctcctt ggtggcccct    900

gcactcgcca tgatctccca ccctgtgcca ttcccacatc cgtgaatgct cctcccctgt    960

cccctttctg ctctcccggg actcaggaac gaggtcttcc ctcgaccctg ctcatcccct   1020

gtgctctctg acttccccac cataccataa cctcctcaag ggcaaggaac gtttgttttc   1080

tacctcagta ttgctgacat cagcccaact cctggcacag agttgcagaa taaaacagga   1140

ggcatcatgg ttacttccat tcagacagcc acaagcccca acaccaaagg gacttggtcc   1200

taaaattcac atcctcctgc cccactgacc cctgccaggc cttggtggaa gttctgtcca   1260

cagagtgcac acgtgggtgt ctgaatcttt gtgtatcatc cagctccctt tcttgcccag   1320

caggtgctgg atgtgtctgg ggcagacatg ttggccaagt caattgccaa ctgccaggtg   1380

gagcttctgg aaaactgtgg gcactcagta gtgatggaaa gacccaggaa gacagccaag   1440

ctcataatcg actttttagc ttctgtgcac aacacagaca acaacaagaa gctggactga   1500

ggccccgact gcagcctgca ttctgcacac acattagtcc tcattcgctg aaccctgttg   1560

tttaggtcta atttaagttt tacatagaga cccatgtatg actgcagccc attggctgca   1620

agaccaggga ggaaagtggc aagctgtaga aaatgtttac acgcatggag gggcattgct   1680

ctagccctca gagcgtccgg agcagcaggg tacatgggtg ggaggttcat tcagcaccca   1740

ccagtcaggt atgttctgag tgaacccaca gcagtcgcag aatgagcacc tggcagggtg   1800

ggtttcctag gaataattta ttatttttaa aaataggcct aataaagcaa taatgttcta   1860

gacatctgtc taagtaatca gactcaggtt ccacacacaa gcaacaactc gtgggcctct   1920

tttctatttc aatgtgctac taagaaccct tggatgtaac atactagtta gttaatgaat   1980

tctgtgaatt ctgtgaagag taatgtgatt gaaaataagt ctaaacagct gtaaaagtga   2040

ccacaatgac atgaaataaa tttaataagt ctagatcagc aac                     2083


<210>  9479
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  9479

Met Leu Gly Lys Lys Met Glu Val Asp Trp His Ser Ser Trp Glu Pro 
1               5                   10                  15      


Arg Gly Lys Gly Glu Glu Met Ser Cys Leu Lys Arg Ile Ser Pro Gly 
            20                  25                  30          


Lys Val Leu Ala Phe Met Leu Glu Lys His Ser Pro Tyr Leu Gln Arg 
        35                  40                  45              


Leu Glu Pro Arg Asn Thr Gln Leu Trp Gly Ser Pro Glu Asp Leu Gln 
    50                  55                  60                  


Arg Asp Leu Gln Leu Gly Ala Val Ala Gln Ala Cys Asn Pro Ser Thr 
65                  70                  75                  80  


Leu Gly Gly 
            


<210>  9480
<211>  2752
<212>  DNA
<213>  Homosapiens

<400>  9480
atttgagttg gtgagaatag agcaaagaca cagaaggtgc ttgagtttgt tggggctttt     60

gcttttgccg ttaaggatgg ggaggagggg ccctcttgtc taggatgaat tgaaggtaaa    120

ggcagctaag agaaggggag tgaatgcgga tccacttctg agggaggatg ttggggaaaa    180

agatggaggt ggattggcat agtagctggg aacccagagg aaaaggagag gaaatgagtt    240

gtttgaaaag gatcagccct ggaaaagttc tggctttcat gttggaaaag cattccccat    300

atctgcagag gttagagcca agaaacacac agctctgggg atccccagag gaccttcaaa    360

gagacctcca gctgggtgcg gtggctcagg cctgtaatcc tagcactttg ggaggctgag    420

gcaggtggat cacctgaggt caggagttcg agaccagcct ggccaacgtg gtgaaacccc    480

atctctacta gaaatacaaa aattagctgg gcatggtggc gggcacctat aatcccagct    540

actggggagg ctgaggcaga agatcacttg aacctgggag gcggaggttg cagtgagttg    600

agatcacgcc acttcattcc agcctgggcg aaagagtgaa actccttttc aacaaataaa    660

gagatacccc cagcttgtga taattagcct tcccctcttg catccttcct acagcttggg    720

ctgccctaac cagccacagg gccagcctga tcaagtcact caccttaaca cagcctgtgg    780

ttccccatgg tccgtgtggc tgtaggagca gcgccctcct ctctgcccct tctccccacc    840

atgccacccc cactgcccat gtgcttggtg tctcagccgc cgtgctcctt ggtggcccct    900

gcactcgcca tgatctccca ccctgtgcca ttcccacatc cgtgaatgct cctcccctgt    960

cccctttctg ctctcccggg actcaggaac gaggtcttcc ctcgaccctg ctcatcccct   1020

gtgctctctg acttccccac cataccataa cctcctcaag ggcaaggaac gtttgttttc   1080

tacctcagta ttgctgacat cagcccaact cctggcacag agttgcagaa taaaacagga   1140

ggcatcatgg ttacttccat tcagacagcc acaagcccca acaccaaagg gacttggtcc   1200

taaaattcac atcctcctgc cccactgacc cctgccaggc cttggtggaa gttctgtcca   1260

cagagtgcac acgtgggtgt ctgaatcttt gtgtatcatc cagctccctt tcttgcccag   1320

caggtgctgg atgtgtctgg ggcagacatg ttggccaagt caattgccaa ctgccaggtg   1380

gagcttctgg aaaactgtgg gcactcagta gtgatggaaa gacccaggaa gacagccaag   1440

ctcataatcg actttttagc ttctgtgcac aacacagaca acaacaagaa gctggactga   1500

ggccccgact gcagcctgca ttctgcacac acattagtcc tcattcgctg aaccctgttg   1560

tttaggtcta atttaagttt tacatagaga cccatgtatg actgcagccc attggctgca   1620

agaccaggga ggaaagtggc aagctgtaga aaatgtttac acgcatggag gggcattgct   1680

ctagccctca gagcgtccgg agcagcaggg tacatgggtg ggaggttcat tcagcaccca   1740

ccagtcaggt atgttctgag tgaacccaca gcagtcgcag aatgagcacc tggcagggtg   1800

ggtttcctag gaataattta ttatttttaa aaataggcct aataaagcaa taatgttcta   1860

gacatctgtc taagtaatca gactcaggtt ccacacacaa gcaacaactc gtgggcctct   1920

tttctatttc aatgtgctac taagaaccct tggatgtaac atactagtta gttaatgaat   1980

tctgtgaatt ctgtgaagag taatgtgatt gaaaataagt ctaaacagct gtaaaagtga   2040

ccacaatgac atgaaataaa tttaataagt ctagatcagc aacatgcagg tggtttctat   2100

ttctgaactc ctaattaggt gcaatgttgg cagattttct gttaacttta aaatgtgttt   2160

tttaaaataa ggcttgttta acaggctttg gaagtctttg catggatgat ttattaggtt   2220

taaggaatca tgtttgcaat ttttatccag ttgaaattgt atatcaaagg ccaggtgcag   2280

tggctcatgc ctgtaatccc agcacttgag aaggccgagg tgggtcgatt gcttgaggcc   2340

aggagttcaa gaccaacctg gccaacatgg caaaatctta tctctactaa aaatgcaaaa   2400

attatctggg cgtggtggga cacacctgta atcccagcta cctgggagcc tgaggcatga   2460

gaatcgcttg aacccgggag gcggaggtta cagtgagccg agattgtgcc attgcactcc   2520

agcctgggca ataagcgcaa aaatccatct caaaataata taataataat tcactggaaa   2580

ttgtatatca aaaaaggcaa gagtcatcaa aatattcttt ttgactcttt ctgtaggatt   2640

taggagccct aaactcccca ggagcttcac tctttccaat ttttttttta cagaaaatct   2700

acagccaagt cattctggga ataaagtgag ataaacttta cagtttaaat ct           2752


<210>  9481
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  9481

Met Leu Gly Lys Lys Met Glu Val Asp Trp His Ser Ser Trp Glu Pro 
1               5                   10                  15      


Arg Gly Lys Gly Glu Glu Met Ser Cys Leu Lys Arg Ile Ser Pro Gly 
            20                  25                  30          


Lys Val Leu Ala Phe Met Leu Glu Lys His Ser Pro Tyr Leu Gln Arg 
        35                  40                  45              


Leu Glu Pro Arg Asn Thr Gln Leu Trp Gly Ser Pro Glu Asp Leu Gln 
    50                  55                  60                  


Arg Asp Leu Gln Leu Gly Ala Val Ala Gln Ala Cys Asn Pro Ser Thr 
65                  70                  75                  80  


Leu Gly Gly 
            


<210>  9482
<211>  386
<212>  DNA
<213>  Homosapiens

<400>  9482
tacatgggtg ggaggttcat tcagcaccca ccagtcagaa aatctacagc caagtcattc     60

tgggaataaa gtgagataaa ctttacagtt taaatctgaa ttcaggactg tgtttgaata    120

tttcagttta ccagagaaga atggaactta gagcttaaaa acaagaagaa gatatgaaaa    180

tatgacatca agctgggctg cagctaaagc agtgcctcag agggaaattc ataggcttca    240

atacgtatat tagaagggaa gaggctaggt ggagtagctc acacctgtag tttcaacacc    300

ttgggaggcc aaggcgggag gactgcttga gcccaggagt ttgagaccag cctgggcaac    360

atggcaagac cccatctctt atataa                                         386


<210>  9483
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  9483

Leu Thr Pro Val Val Ser Thr Pro Trp Glu Ala Lys Ala Gly Gly Leu 
1               5                   10                  15      


Leu Glu Pro Arg Ser Leu Arg Pro Ala Trp Ala Thr Trp Gln Asp Pro 
            20                  25                  30          


Ile Ser Tyr 
        35  


<210>  9484
<211>  1045
<212>  DNA
<213>  Homosapiens

<400>  9484
acgcttcgtg gggcgggacg aggagaagcc aaacgtaaag acaccaggag tttctcgggc     60

ccagctgtgg ctgctgccgg ggagccccaa gccttggcgg gtccttgcgg cgaataggag    120

tctggtcagg cgtcaggcta gtccgacgaa gagtggagaa tttcaagatt gtggagttgg    180

actgaatgct gcacagttca aacagctgct tatttcggct gtgaaggacc tgtttgggga    240

ggttgatgcc gccttacctt tggacatcct aacctatgaa gagaagacct tgtcagccat    300

cttgagaata tgtagcagtg gtcttgtcaa attgtggagc tctttgaccc tgttaggatc    360

ctataaaggc aaaaaatgtg ctttccgggt gattcaggtt tctccatttc ttcttgcatt    420

atctggtaat agtagggaac tagtattgga ttgaatgaat agtcttccat tttggaaacg    480

ttcatccact ctcatattta ttttttggtg cctgcatgtt tgaagactga agcaggctaa    540

aagctcttga tgaaatttga gggtgctgaa gatgttccca ctaatttcca gccatcacct    600

ttggtggggt gggcttcgga ggacagtctg tctgaacctg ccagtgctga ccctgcagca    660

ctttcagcat atgcacatca aagttggaga ccgcgctgaa cttaggaggg ccttcacaca    720

gactgatgtg gctaccttct cagaattaac aggggatgtc aatcctttgc atttgaatga    780

agactttgca aaacacacca agtttggaaa tacaattgta catggagttt tgatcaacgg    840

acttatctca gctctcctag gaactaaaat gccagggcca ggctgtgtat ttctttccca    900

ggaaattagc tttccagccc ctttatatat tggagaagtt gttttagctt ctgcagaagt    960

gaaaaagctg aagcggttca ttgctattat tgcagtgtca tgttctgtaa tagaaagtaa   1020

aaagactgtt atggaaggct gggtt                                         1045


<210>  9485
<211>  157
<212>  PRT
<213>  Homosapiens

<400>  9485

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp 
145                 150                 155         


<210>  9486
<211>  960
<212>  DNA
<213>  Homosapiens

<400>  9486
acgcttcgtg gggcgggacg aggagaagcc aaacgtaaag acaccaggag tttctcgggc     60

ccagctgtgg ctgctgccgg ggagccccaa gccttggcgg gtccttgcgg cgaataggag    120

tctggtcagg cgtcaggcta gtccgacgaa gagtgggttg atgccgcctt acctttggac    180

atcctaacct atgaagagaa gaccttgtca gccatcttga gaatatgtag cagtggtctt    240

gtcaaattgt ggagctcttt gaccctgtta ggatcctata aaggcaaaaa atgtgctttc    300

cgggtgattc aggtttctcc atttcttctt gcattatctg gtaatagtag ggaactagta    360

ttggattgaa tgaatagtct tccattttgg aaacgttcat ccactctcat atttattttt    420

tggtgcctgc atgtttgaag actgaagcag gctaaaagct cttgatgaaa tttgagggtg    480

ctgaagatgt tcccactaat ttccagccat cacctttggt ggggtgggct tcggaggaca    540

gtctgtctga acctgccagt gctgaccctg cagcactttc agcatatgca catcaaagtt    600

ggagaccgcg ctgaacttag gagggccttc acacagactg atgtggctac cttctcagaa    660

ttaacagggg atgtcaatcc tttgcatttg aatgaagact ttgcaaaaca caccaagttt    720

ggaaatacaa ttgtacatgg agttttgatc aacggactta tctcagctct cctaggaact    780

aaaatgccag ggccaggctg tgtatttctt tcccaggaaa ttagctttcc agccccttta    840

tatattggag aagttgtttt agcttctgca gaagtgaaaa agctgaagcg gttcattgct    900

attattgcag tgtcatgttc tgtaatagaa agtaaaaaga ctgttatgga aggctgggtt    960


<210>  9487
<211>  157
<212>  PRT
<213>  Homosapiens

<400>  9487

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp 
145                 150                 155         


<210>  9488
<211>  2630
<212>  DNA
<213>  Homosapiens

<400>  9488
acgcttcgtg gggcgggacg aggagaagcc aaacgtaaag acaccaggag tttctcgggc     60

ccagctgtgg ctgctgccgg ggagccccaa gccttggcgg gtccttgcgg cgaataggag    120

tctggtcagg cgtcaggcta gtccgacgaa gagtggagaa tttcaagatt gtggagttgg    180

actgaatgct gcacagttca aacagctgct tatttcggct gtgaaggacc tgtttgggga    240

ggttgatgcc gccttacctt tggacatcct aacctatgaa gagaagacct tgtcagccat    300

cttgagaata tgtagcagtg gtcttgtcaa attgtggagc tctttgaccc tgttaggatc    360

ctataaaggc aaaaaatgtg ctttccgggt gattcaggtt tctccatttc ttcttgcatt    420

atctggtaat agtagggaac tagtattgga ttgaatgaat agtcttccat tttggaaacg    480

ttcatccact ctcatattta ttttttggtg cctgcatgtt tgaagactga agcaggctaa    540

aagctcttga tgaaatttga gggtgctgaa gatgttccca ctaatttcca gccatcacct    600

ttggtggggt gggcttcgga ggacagtctg tctgaacctg ccagtgctga ccctgcagca    660

ctttcagcat atgcacatca aagttggaga ccgcgctgaa cttaggaggg ccttcacaca    720

gactgatgtg gctaccttct cagaattaac aggggatgtc aatcctttgc atttgaatga    780

agactttgca aaacacacca agtttggaaa tacaattgta catggagttt tgatcaacgg    840

acttatctca gctctcctag gaactaaaat gccagggcca ggctgtgtat ttctttccca    900

ggaaattagc tttccagccc ctttatatat tggagaagtt gttttagctt ctgcagaagt    960

gaaaaagctg aagcggttca ttgctattat tgcagtgtca tgttctgtaa tagaaagtaa   1020

aaagactgtt atggaaggct gggttaaagt tatggttcca gaagcttcca aatcctgaaa   1080

tagatgtttt aaagatgcaa cctcaaacac caatgctgtt gttaaagagc ctatggggaa   1140

ttgctgctct ttaccaaaga atggttgata ggcccagaag cccatcttag ttaggggaag   1200

ggagcaggaa gagggttgtt caaatgccca ctttccagtt tggccttatg cttcatgcag   1260

acttgagtgt atgcaggatt tcattatctg cctgggtttt ttgtttgttt tttgtttttt   1320

aattcaagaa gtaggctggg cccggtggct catgcctgta atcctggcac tttgggaggc   1380

tgcggcaggc ggatcacttg aggtcaggag tccaagacca gcctggccaa catggtgaaa   1440

ccccatctct accaaaaaaa aaaaaaaaaa aaaagtgcaa ctagctgtgc ttggtgactt   1500

ggccctgtag tcccagttgc ttgggaggct gaggtgggag aattgcttgg gcctgagagc   1560

tggaggttat ggtgagaaac tgagattgca ccactgcact gtagcctgag tgacagagcg   1620

agaccctgtc tcaagaaaga agtattggga aggttattta aagactctac ttttaaatca   1680

ggcgtggcag ctcacgcctg taatcccagc attttgggag gctgaggcag gcgaatcact   1740

tgaggtcagg agttcaagac cagcctggcc aacatgtgaa accccatctc tactaaaaat   1800

acaaaaacta accgggcatg gtggcgggca cctgtaatcc cagctacttg ggaggctgag   1860

gcaggagaat ctcttgaacc tgggaggttg cagtgagctg aaatcacacc actgcacttc   1920

agcctgggtg acagagcaaa actccacctc aaaaaaaaaa aaaagattct acttttagaa   1980

attcagacct agatagattt gcatttggat aacaaatccc tacctatagc catgtggaag   2040

cagcttgtca ctgtatttta actgtgtaac aattattgaa ggcgaaaata gaagttgggt   2100

catctttgaa cacctacctt ttatcaatga atatttttag actgttcttc agtatctgag   2160

tcagagttta ttgtaatttg ttatttacac caaggtggca tcttagtcta ccttcagtga   2220

gacttgcgtt tcaggggagg ggcgtatgtg catcctcggt ctcagttatg taaacggtct   2280

gatctgtaaa atagtggtag cacatgccat gtgggatagt tggtggagat gatagatgga   2340

gttaagcaca gggcccagcc tgtcagcagt agctactatt attgttgccc atttcccctg   2400

caactgaggt gagaggtttt cctgagtttg aagctgactg gcccacagtt aaacgtaaca   2460

gaccagtttt tcagggtgtc agccaacctc tattagtgtt cttaagtaca gtttctgtta   2520

taaaagttca gattattcct tgaaaatttg gatctacctc ccattattat gagtaataca   2580

tgcttatagt aaaaaaaaaa aaattgtaag aaataaatat taagaagatt              2630


<210>  9489
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  9489

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp Val Lys Val 
145                 150                 155                 160 


Met Val Pro Glu Ala Ser Lys Ser 
                165             


<210>  9490
<211>  2545
<212>  DNA
<213>  Homosapiens

<400>  9490
acgcttcgtg gggcgggacg aggagaagcc aaacgtaaag acaccaggag tttctcgggc     60

ccagctgtgg ctgctgccgg ggagccccaa gccttggcgg gtccttgcgg cgaataggag    120

tctggtcagg cgtcaggcta gtccgacgaa gagtgggttg atgccgcctt acctttggac    180

atcctaacct atgaagagaa gaccttgtca gccatcttga gaatatgtag cagtggtctt    240

gtcaaattgt ggagctcttt gaccctgtta ggatcctata aaggcaaaaa atgtgctttc    300

cgggtgattc aggtttctcc atttcttctt gcattatctg gtaatagtag ggaactagta    360

ttggattgaa tgaatagtct tccattttgg aaacgttcat ccactctcat atttattttt    420

tggtgcctgc atgtttgaag actgaagcag gctaaaagct cttgatgaaa tttgagggtg    480

ctgaagatgt tcccactaat ttccagccat cacctttggt ggggtgggct tcggaggaca    540

gtctgtctga acctgccagt gctgaccctg cagcactttc agcatatgca catcaaagtt    600

ggagaccgcg ctgaacttag gagggccttc acacagactg atgtggctac cttctcagaa    660

ttaacagggg atgtcaatcc tttgcatttg aatgaagact ttgcaaaaca caccaagttt    720

ggaaatacaa ttgtacatgg agttttgatc aacggactta tctcagctct cctaggaact    780

aaaatgccag ggccaggctg tgtatttctt tcccaggaaa ttagctttcc agccccttta    840

tatattggag aagttgtttt agcttctgca gaagtgaaaa agctgaagcg gttcattgct    900

attattgcag tgtcatgttc tgtaatagaa agtaaaaaga ctgttatgga aggctgggtt    960

aaagttatgg ttccagaagc ttccaaatcc tgaaatagat gttttaaaga tgcaacctca   1020

aacaccaatg ctgttgttaa agagcctatg gggaattgct gctctttacc aaagaatggt   1080

tgataggccc agaagcccat cttagttagg ggaagggagc aggaagaggg ttgttcaaat   1140

gcccactttc cagtttggcc ttatgcttca tgcagacttg agtgtatgca ggatttcatt   1200

atctgcctgg gttttttgtt tgttttttgt tttttaattc aagaagtagg ctgggcccgg   1260

tggctcatgc ctgtaatcct ggcactttgg gaggctgcgg caggcggatc acttgaggtc   1320

aggagtccaa gaccagcctg gccaacatgg tgaaacccca tctctaccaa aaaaaaaaaa   1380

aaaaaaaaag tgcaactagc tgtgcttggt gacttggccc tgtagtccca gttgcttggg   1440

aggctgaggt gggagaattg cttgggcctg agagctggag gttatggtga gaaactgaga   1500

ttgcaccact gcactgtagc ctgagtgaca gagcgagacc ctgtctcaag aaagaagtat   1560

tgggaaggtt atttaaagac tctactttta aatcaggcgt ggcagctcac gcctgtaatc   1620

ccagcatttt gggaggctga ggcaggcgaa tcacttgagg tcaggagttc aagaccagcc   1680

tggccaacat gtgaaacccc atctctacta aaaatacaaa aactaaccgg gcatggtggc   1740

gggcacctgt aatcccagct acttgggagg ctgaggcagg agaatctctt gaacctggga   1800

ggttgcagtg agctgaaatc acaccactgc acttcagcct gggtgacaga gcaaaactcc   1860

acctcaaaaa aaaaaaaaag attctacttt tagaaattca gacctagata gatttgcatt   1920

tggataacaa atccctacct atagccatgt ggaagcagct tgtcactgta ttttaactgt   1980

gtaacaatta ttgaaggcga aaatagaagt tgggtcatct ttgaacacct accttttatc   2040

aatgaatatt tttagactgt tcttcagtat ctgagtcaga gtttattgta atttgttatt   2100

tacaccaagg tggcatctta gtctaccttc agtgagactt gcgtttcagg ggaggggcgt   2160

atgtgcatcc tcggtctcag ttatgtaaac ggtctgatct gtaaaatagt ggtagcacat   2220

gccatgtggg atagttggtg gagatgatag atggagttaa gcacagggcc cagcctgtca   2280

gcagtagcta ctattattgt tgcccatttc ccctgcaact gaggtgagag gttttcctga   2340

gtttgaagct gactggccca cagttaaacg taacagacca gtttttcagg gtgtcagcca   2400

acctctatta gtgttcttaa gtacagtttc tgttataaaa gttcagatta ttccttgaaa   2460

atttggatct acctcccatt attatgagta atacatgctt atagtaaaaa aaaaaaaatt   2520

gtaagaaata aatattaaga agatt                                         2545


<210>  9491
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  9491

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp Val Lys Val 
145                 150                 155                 160 


Met Val Pro Glu Ala Ser Lys Ser 
                165             


<210>  9492
<211>  3150
<212>  DNA
<213>  Homosapiens

<400>  9492
acgcttcgtg gggcgggacg aggagaagcc aaacgtaaag acaccaggag tttctcgggc     60

ccagctgtgg ctgctgccgg ggagccccaa gccttggcgg gtccttgcgg cgaataggag    120

tctggtcagg cgtcaggcta gtccgacgaa gagtggagaa tttcaagatt gtggagttgg    180

actgaatgct gcacagttca aacagctgct tatttcggct gtgaaggacc tgtttgggga    240

ggttgatgcc gccttacctt tggacatcct aacctatgaa gagaagacct tgtcagccat    300

cttgagaata tgtagcagtg gtcttgtcaa attgtggagc tctttgaccc tgttaggatc    360

ctataaaggc aaaaaatgtg ctttccgggt gattcaggtt tctccatttc ttcttgcatt    420

atctggtaat agtagggaac tagtattgga ttgaatgaat agtcttccat tttggaaacg    480

ttcatccact ctcatattta ttttttggtg cctgcatgtt tgaagactga agcaggctaa    540

aagctcttga tgaaatttga gggtgctgaa gatgttccca ctaatttcca gccatcacct    600

ttggtggggt gggcttcgga ggacagtctg tctgaacctg ccagtgctga ccctgcagca    660

ctttcagcat atgcacatca aagttggaga ccgcgctgaa cttaggaggg ccttcacaca    720

gactgatgtg gctaccttct cagaattaac aggggatgtc aatcctttgc atttgaatga    780

agactttgca aaacacacca agtttggaaa tacaattgta catggagttt tgatcaacgg    840

acttatctca gctctcctag gaactaaaat gccagggcca ggctgtgtat ttctttccca    900

ggaaattagc tttccagccc ctttatatat tggagaagtt gttttagctt ctgcagaagt    960

gaaaaagctg aagcggttca ttgctattat tgcagtgtca tgttctgtaa tagaaagtaa   1020

aaagactgtt atggaaggct gggttaaagt tatggttcca gaagcttcca aatcctgaaa   1080

tagatgtttt aaagatgcaa cctcaaacac caatgctgtt gttaaagagc ctatggggaa   1140

ttgctgctct ttaccaaaga atggttgata ggcccagaag cccatcttag ttaggggaag   1200

ggagcaggaa gagggttgtt caaatgccca ctttccagtt tggccttatg cttcatgcag   1260

acttgagtgt atgcaggatt tcattatctg cctgggtttt ttgtttgttt tttgtttttt   1320

aattcaagaa gtaggctggg cccggtggct catgcctgta atcctggcac tttgggaggc   1380

tgcggcaggc ggatcacttg aggtcaggag tccaagacca gcctggccaa catggtgaaa   1440

ccccatctct accaaaaaaa aaaaaaaaaa aaaagtgcaa ctagctgtgc ttggtgactt   1500

ggccctgtag tcccagttgc ttgggaggct gaggtgggag aattgcttgg gcctgagagc   1560

tggaggttat ggtgagaaac tgagattgca ccactgcact gtagcctgag tgacagagcg   1620

agaccctgtc tcaagaaaga agtattggga aggttattta aagactctac ttttaaatca   1680

ggcgtggcag ctcacgcctg taatcccagc attttgggag gctgaggcag gcgaatcact   1740

tgaggtcagg agttcaagac cagcctggcc aacatgtgaa accccatctc tactaaaaat   1800

acaaaaacta accgggcatg gtggcgggca cctgtaatcc cagctacttg ggaggctgag   1860

gcaggagaat ctcttgaacc tgggaggttg cagtgagctg aaatcacacc actgcacttc   1920

agcctgggtg acagagcaaa actccacctc aaaaaaaaaa aaaagattct acttttagaa   1980

attcagacct agatagattt gcatttggat aacaaatccc tacctatagc catgtggaag   2040

cagcttgtca ctgtatttta actgtgtaac aattattgaa ggcgaaaata gaagttgggt   2100

catctttgaa cacctacctt ttatcaatga atatttttag actgttcttc agtatctgag   2160

tcagagttta ttgtaatttg ttatttacac caaggtggca tcttagtcta ccttcagtga   2220

gacttgcgtt tcaggggagg ggcgtatgtg catcctcggt ctcagttatg taaacggtct   2280

gatctgtaaa atagtggtag cacatgccat gtgggatagt tggtggagat gatagatgga   2340

gttaagcaca gggcccagcc tgtcagcagt agctactatt attgttgccc atttcccctg   2400

caactgaggt gagaggtttt cctgagtttg aagctgactg gcccacagtt aaacgtaaca   2460

gaccagtttt tcagggtgtc agccaacctc tattagtgtt cttaagtaca gtttctgtta   2520

taaaagttca gattattcct tgaaaatttg gatctacctc ccattattat gagtaataca   2580

tgcttatagt aaaaaaaaaa aaattgtaag aaataaatat taagaagatt atggaggcca   2640

aattcttaag actttggggg ctggggtcag ggaggttata ttgaagggga gatgtgccta   2700

acatgttact actaaatggc catcccaaca cagccaacac ttttgtttcc catttttttt   2760

tgtttcccgt tttttaataa aattgagata taattcacat accataaaat tcacctttta   2820

aaagtgtaca gtttagtggt tttcagaata tccacaaagt tgtacaacca tcaccaaatc   2880

aattttttat agcatttttc atcaccccca aaagaacctc ccattagcag tcaatccatt   2940

tctctcctcc agtctttggg aatcaccagt ctactttctg tctctatggg tttccctgtt   3000

ctggacattt cataaaagtt catacaatgt atgatccttt ggaactggct tctttgatat   3060

agcatgtttt cagggttcat ccatgttaca gcatgtatca gtacatcatt ttattttatg   3120

gctgaataat attccattgt atttacccat                                    3150


<210>  9493
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  9493

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp Val Lys Val 
145                 150                 155                 160 


Met Val Pro Glu Ala Ser Lys Ser 
                165             


<210>  9494
<211>  3065
<212>  DNA
<213>  Homosapiens

<400>  9494
acgcttcgtg gggcgggacg aggagaagcc aaacgtaaag acaccaggag tttctcgggc     60

ccagctgtgg ctgctgccgg ggagccccaa gccttggcgg gtccttgcgg cgaataggag    120

tctggtcagg cgtcaggcta gtccgacgaa gagtgggttg atgccgcctt acctttggac    180

atcctaacct atgaagagaa gaccttgtca gccatcttga gaatatgtag cagtggtctt    240

gtcaaattgt ggagctcttt gaccctgtta ggatcctata aaggcaaaaa atgtgctttc    300

cgggtgattc aggtttctcc atttcttctt gcattatctg gtaatagtag ggaactagta    360

ttggattgaa tgaatagtct tccattttgg aaacgttcat ccactctcat atttattttt    420

tggtgcctgc atgtttgaag actgaagcag gctaaaagct cttgatgaaa tttgagggtg    480

ctgaagatgt tcccactaat ttccagccat cacctttggt ggggtgggct tcggaggaca    540

gtctgtctga acctgccagt gctgaccctg cagcactttc agcatatgca catcaaagtt    600

ggagaccgcg ctgaacttag gagggccttc acacagactg atgtggctac cttctcagaa    660

ttaacagggg atgtcaatcc tttgcatttg aatgaagact ttgcaaaaca caccaagttt    720

ggaaatacaa ttgtacatgg agttttgatc aacggactta tctcagctct cctaggaact    780

aaaatgccag ggccaggctg tgtatttctt tcccaggaaa ttagctttcc agccccttta    840

tatattggag aagttgtttt agcttctgca gaagtgaaaa agctgaagcg gttcattgct    900

attattgcag tgtcatgttc tgtaatagaa agtaaaaaga ctgttatgga aggctgggtt    960

aaagttatgg ttccagaagc ttccaaatcc tgaaatagat gttttaaaga tgcaacctca   1020

aacaccaatg ctgttgttaa agagcctatg gggaattgct gctctttacc aaagaatggt   1080

tgataggccc agaagcccat cttagttagg ggaagggagc aggaagaggg ttgttcaaat   1140

gcccactttc cagtttggcc ttatgcttca tgcagacttg agtgtatgca ggatttcatt   1200

atctgcctgg gttttttgtt tgttttttgt tttttaattc aagaagtagg ctgggcccgg   1260

tggctcatgc ctgtaatcct ggcactttgg gaggctgcgg caggcggatc acttgaggtc   1320

aggagtccaa gaccagcctg gccaacatgg tgaaacccca tctctaccaa aaaaaaaaaa   1380

aaaaaaaaag tgcaactagc tgtgcttggt gacttggccc tgtagtccca gttgcttggg   1440

aggctgaggt gggagaattg cttgggcctg agagctggag gttatggtga gaaactgaga   1500

ttgcaccact gcactgtagc ctgagtgaca gagcgagacc ctgtctcaag aaagaagtat   1560

tgggaaggtt atttaaagac tctactttta aatcaggcgt ggcagctcac gcctgtaatc   1620

ccagcatttt gggaggctga ggcaggcgaa tcacttgagg tcaggagttc aagaccagcc   1680

tggccaacat gtgaaacccc atctctacta aaaatacaaa aactaaccgg gcatggtggc   1740

gggcacctgt aatcccagct acttgggagg ctgaggcagg agaatctctt gaacctggga   1800

ggttgcagtg agctgaaatc acaccactgc acttcagcct gggtgacaga gcaaaactcc   1860

acctcaaaaa aaaaaaaaag attctacttt tagaaattca gacctagata gatttgcatt   1920

tggataacaa atccctacct atagccatgt ggaagcagct tgtcactgta ttttaactgt   1980

gtaacaatta ttgaaggcga aaatagaagt tgggtcatct ttgaacacct accttttatc   2040

aatgaatatt tttagactgt tcttcagtat ctgagtcaga gtttattgta atttgttatt   2100

tacaccaagg tggcatctta gtctaccttc agtgagactt gcgtttcagg ggaggggcgt   2160

atgtgcatcc tcggtctcag ttatgtaaac ggtctgatct gtaaaatagt ggtagcacat   2220

gccatgtggg atagttggtg gagatgatag atggagttaa gcacagggcc cagcctgtca   2280

gcagtagcta ctattattgt tgcccatttc ccctgcaact gaggtgagag gttttcctga   2340

gtttgaagct gactggccca cagttaaacg taacagacca gtttttcagg gtgtcagcca   2400

acctctatta gtgttcttaa gtacagtttc tgttataaaa gttcagatta ttccttgaaa   2460

atttggatct acctcccatt attatgagta atacatgctt atagtaaaaa aaaaaaaatt   2520

gtaagaaata aatattaaga agattatgga ggccaaattc ttaagacttt gggggctggg   2580

gtcagggagg ttatattgaa ggggagatgt gcctaacatg ttactactaa atggccatcc   2640

caacacagcc aacacttttg tttcccattt ttttttgttt cccgtttttt aataaaattg   2700

agatataatt cacataccat aaaattcacc ttttaaaagt gtacagttta gtggttttca   2760

gaatatccac aaagttgtac aaccatcacc aaatcaattt tttatagcat ttttcatcac   2820

ccccaaaaga acctcccatt agcagtcaat ccatttctct cctccagtct ttgggaatca   2880

ccagtctact ttctgtctct atgggtttcc ctgttctgga catttcataa aagttcatac   2940

aatgtatgat cctttggaac tggcttcttt gatatagcat gttttcaggg ttcatccatg   3000

ttacagcatg tatcagtaca tcattttatt ttatggctga ataatattcc attgtattta   3060

cccat                                                               3065


<210>  9495
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  9495

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp Val Lys Val 
145                 150                 155                 160 


Met Val Pro Glu Ala Ser Lys Ser 
                165             


<210>  9496
<211>  1372
<212>  DNA
<213>  Homosapiens

<400>  9496
tcgtggggcg ggacgaggag aagccaaacg taaagacacc aggagtttct cgggcccagc     60

tgtggctgct gccggggagc cccaagcctt ggcgggtcct tgcggcgaat aggagtctgg    120

tcaggcgtca ggctagtccg acgaagagtg ggtaggtgga agccttccaa agagcggcgg    180

ttgtctggga gccgtctcag ttggccgcga cccgggcgca tgcgcggggc gggcggtgcg    240

ccttgggtag cttgtcctct ccgaccccgg gcgctgaggg cctctgtacg gcgccgcgta    300

gggtctcggc cgcagaacgt ggccgagagg cccgggcgag acttcgggac cgtgtcctga    360

gcgctctcca tgcgcccggc gcgaggtgtg atcagcactg gaaaagatgc ctgcccctgc    420

tgccacatat gaaagagtag tttacaaaaa cccttccgag taccactaca tgaaagtctg    480

cctagaattt caagattgtg gagttggact gaatgctgca cagttcaaac agctgcttat    540

ttcggctgtg aaggacctgt ttggggaggt tgatgccgcc ttacctttgg acatcctaac    600

ctatgaagag aagaccttgt cagccatctt gagaatatgt agcagtggtc ttgtcaaatt    660

gtggagctct ttgaccctgt taggatccta taaaggcaaa aaatgtgctt tccgggtgat    720

tcaggtttct ccatttcttc ttgcattatc tggtaatagt agggaactag tattggattg    780

aatgaatagt cttccatttt ggaaacgttc atccactctc atatttattt tttggtgcct    840

gcatgtttga agactgaagc aggctaaaag ctcttgatga aatttgaggg tgctgaagat    900

gttcccacta atttccagcc atcacctttg gtggggtggg cttcggagga cagtctgtct    960

gaacctgcca gtgctgaccc tgcagcactt tcagcatatg cacatcaaag ttggagaccg   1020

cgctgaactt aggagggcct tcacacagac tgatgtggct accttctcag aattaacagg   1080

ggatgtcaat cctttgcatt tgaatgaaga ctttgcaaaa cacaccaagt ttggaaatac   1140

aattgtacat ggagttttga tcaacggact tatctcagct ctcctaggaa ctaaaatgcc   1200

agggccaggc tgtgtatttc tttcccagga aattagcttt ccagcccctt tatatattgg   1260

agaagttgtt ttagcttctg cagaagtgaa aaagctgaag cggttcattg ctattattgc   1320

agtgtcatgt tctgtaatag aaagtaaaaa gactgttatg gaaggctggg tt           1372


<210>  9497
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  9497

Met Pro Ala Pro Ala Ala Thr Tyr Glu Arg Val Val Tyr Lys Asn Pro 
1               5                   10                  15      


Ser Glu Tyr His Tyr Met Lys Val Cys Leu Glu Phe Gln Asp Cys Gly 
            20                  25                  30          


Val Gly Leu Asn Ala Ala Gln Phe Lys Gln Leu Leu Ile Ser Ala Val 
        35                  40                  45              


Lys Asp Leu Phe Gly Glu Val Asp Ala Ala Leu Pro Leu Asp Ile Leu 
    50                  55                  60                  


Thr Tyr Glu Glu Lys Thr Leu Ser Ala Ile Leu Arg Ile Cys Ser Ser 
65                  70                  75                  80  


Gly Leu Val Lys Leu Trp Ser Ser Leu Thr Leu Leu Gly Ser Tyr Lys 
                85                  90                  95      


Gly Lys Lys Cys Ala Phe Arg Val Ile Gln Val Ser Pro Phe Leu Leu 
            100                 105                 110         


Ala Leu Ser Gly Asn Ser Arg Glu Leu Val Leu Asp 
        115                 120                 


<210>  9498
<211>  2957
<212>  DNA
<213>  Homosapiens

<400>  9498
tcgtggggcg ggacgaggag aagccaaacg taaagacacc aggagtttct cgggcccagc     60

tgtggctgct gccggggagc cccaagcctt ggcgggtcct tgcggcgaat aggagtctgg    120

tcaggcgtca ggctagtccg acgaagagtg ggtaggtgga agccttccaa agagcggcgg    180

ttgtctggga gccgtctcag ttggccgcga cccgggcgca tgcgcggggc gggcggtgcg    240

ccttgggtag cttgtcctct ccgaccccgg gcgctgaggg cctctgtacg gcgccgcgta    300

gggtctcggc cgcagaacgt ggccgagagg cccgggcgag acttcgggac cgtgtcctga    360

gcgctctcca tgcgcccggc gcgaggtgtg atcagcactg gaaaagatgc ctgcccctgc    420

tgccacatat gaaagagtag tttacaaaaa cccttccgag taccactaca tgaaagtctg    480

cctagaattt caagattgtg gagttggact gaatgctgca cagttcaaac agctgcttat    540

ttcggctgtg aaggacctgt ttggggaggt tgatgccgcc ttacctttgg acatcctaac    600

ctatgaagag aagaccttgt cagccatctt gagaatatgt agcagtggtc ttgtcaaatt    660

gtggagctct ttgaccctgt taggatccta taaaggcaaa aaatgtgctt tccgggtgat    720

tcaggtttct ccatttcttc ttgcattatc tggtaatagt agggaactag tattggattg    780

aatgaatagt cttccatttt ggaaacgttc atccactctc atatttattt tttggtgcct    840

gcatgtttga agactgaagc aggctaaaag ctcttgatga aatttgaggg tgctgaagat    900

gttcccacta atttccagcc atcacctttg gtggggtggg cttcggagga cagtctgtct    960

gaacctgcca gtgctgaccc tgcagcactt tcagcatatg cacatcaaag ttggagaccg   1020

cgctgaactt aggagggcct tcacacagac tgatgtggct accttctcag aattaacagg   1080

ggatgtcaat cctttgcatt tgaatgaaga ctttgcaaaa cacaccaagt ttggaaatac   1140

aattgtacat ggagttttga tcaacggact tatctcagct ctcctaggaa ctaaaatgcc   1200

agggccaggc tgtgtatttc tttcccagga aattagcttt ccagcccctt tatatattgg   1260

agaagttgtt ttagcttctg cagaagtgaa aaagctgaag cggttcattg ctattattgc   1320

agtgtcatgt tctgtaatag aaagtaaaaa gactgttatg gaaggctggg ttaaagttat   1380

ggttccagaa gcttccaaat cctgaaatag atgttttaaa gatgcaacct caaacaccaa   1440

tgctgttgtt aaagagccta tggggaattg ctgctcttta ccaaagaatg gttgataggc   1500

ccagaagccc atcttagtta ggggaaggga gcaggaagag ggttgttcaa atgcccactt   1560

tccagtttgg ccttatgctt catgcagact tgagtgtatg caggatttca ttatctgcct   1620

gggttttttg tttgtttttt gttttttaat tcaagaagta ggctgggccc ggtggctcat   1680

gcctgtaatc ctggcacttt gggaggctgc ggcaggcgga tcacttgagg tcaggagtcc   1740

aagaccagcc tggccaacat ggtgaaaccc catctctacc aaaaaaaaaa aaaaaaaaaa   1800

agtgcaacta gctgtgcttg gtgacttggc cctgtagtcc cagttgcttg ggaggctgag   1860

gtgggagaat tgcttgggcc tgagagctgg aggttatggt gagaaactga gattgcacca   1920

ctgcactgta gcctgagtga cagagcgaga ccctgtctca agaaagaagt attgggaagg   1980

ttatttaaag actctacttt taaatcaggc gtggcagctc acgcctgtaa tcccagcatt   2040

ttgggaggct gaggcaggcg aatcacttga ggtcaggagt tcaagaccag cctggccaac   2100

atgtgaaacc ccatctctac taaaaataca aaaactaacc gggcatggtg gcgggcacct   2160

gtaatcccag ctacttggga ggctgaggca ggagaatctc ttgaacctgg gaggttgcag   2220

tgagctgaaa tcacaccact gcacttcagc ctgggtgaca gagcaaaact ccacctcaaa   2280

aaaaaaaaaa agattctact tttagaaatt cagacctaga tagatttgca tttggataac   2340

aaatccctac ctatagccat gtggaagcag cttgtcactg tattttaact gtgtaacaat   2400

tattgaaggc gaaaatagaa gttgggtcat ctttgaacac ctacctttta tcaatgaata   2460

tttttagact gttcttcagt atctgagtca gagtttattg taatttgtta tttacaccaa   2520

ggtggcatct tagtctacct tcagtgagac ttgcgtttca ggggaggggc gtatgtgcat   2580

cctcggtctc agttatgtaa acggtctgat ctgtaaaata gtggtagcac atgccatgtg   2640

ggatagttgg tggagatgat agatggagtt aagcacaggg cccagcctgt cagcagtagc   2700

tactattatt gttgcccatt tcccctgcaa ctgaggtgag aggttttcct gagtttgaag   2760

ctgactggcc cacagttaaa cgtaacagac cagtttttca gggtgtcagc caacctctat   2820

tagtgttctt aagtacagtt tctgttataa aagttcagat tattccttga aaatttggat   2880

ctacctccca ttattatgag taatacatgc ttatagtaaa aaaaaaaaaa ttgtaagaaa   2940

taaatattaa gaagatt                                                  2957


<210>  9499
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  9499

Met Pro Ala Pro Ala Ala Thr Tyr Glu Arg Val Val Tyr Lys Asn Pro 
1               5                   10                  15      


Ser Glu Tyr His Tyr Met Lys Val Cys Leu Glu Phe Gln Asp Cys Gly 
            20                  25                  30          


Val Gly Leu Asn Ala Ala Gln Phe Lys Gln Leu Leu Ile Ser Ala Val 
        35                  40                  45              


Lys Asp Leu Phe Gly Glu Val Asp Ala Ala Leu Pro Leu Asp Ile Leu 
    50                  55                  60                  


Thr Tyr Glu Glu Lys Thr Leu Ser Ala Ile Leu Arg Ile Cys Ser Ser 
65                  70                  75                  80  


Gly Leu Val Lys Leu Trp Ser Ser Leu Thr Leu Leu Gly Ser Tyr Lys 
                85                  90                  95      


Gly Lys Lys Cys Ala Phe Arg Val Ile Gln Val Ser Pro Phe Leu Leu 
            100                 105                 110         


Ala Leu Ser Gly Asn Ser Arg Glu Leu Val Leu Asp 
        115                 120                 


<210>  9500
<211>  3477
<212>  DNA
<213>  Homosapiens

<400>  9500
tcgtggggcg ggacgaggag aagccaaacg taaagacacc aggagtttct cgggcccagc     60

tgtggctgct gccggggagc cccaagcctt ggcgggtcct tgcggcgaat aggagtctgg    120

tcaggcgtca ggctagtccg acgaagagtg ggtaggtgga agccttccaa agagcggcgg    180

ttgtctggga gccgtctcag ttggccgcga cccgggcgca tgcgcggggc gggcggtgcg    240

ccttgggtag cttgtcctct ccgaccccgg gcgctgaggg cctctgtacg gcgccgcgta    300

gggtctcggc cgcagaacgt ggccgagagg cccgggcgag acttcgggac cgtgtcctga    360

gcgctctcca tgcgcccggc gcgaggtgtg atcagcactg gaaaagatgc ctgcccctgc    420

tgccacatat gaaagagtag tttacaaaaa cccttccgag taccactaca tgaaagtctg    480

cctagaattt caagattgtg gagttggact gaatgctgca cagttcaaac agctgcttat    540

ttcggctgtg aaggacctgt ttggggaggt tgatgccgcc ttacctttgg acatcctaac    600

ctatgaagag aagaccttgt cagccatctt gagaatatgt agcagtggtc ttgtcaaatt    660

gtggagctct ttgaccctgt taggatccta taaaggcaaa aaatgtgctt tccgggtgat    720

tcaggtttct ccatttcttc ttgcattatc tggtaatagt agggaactag tattggattg    780

aatgaatagt cttccatttt ggaaacgttc atccactctc atatttattt tttggtgcct    840

gcatgtttga agactgaagc aggctaaaag ctcttgatga aatttgaggg tgctgaagat    900

gttcccacta atttccagcc atcacctttg gtggggtggg cttcggagga cagtctgtct    960

gaacctgcca gtgctgaccc tgcagcactt tcagcatatg cacatcaaag ttggagaccg   1020

cgctgaactt aggagggcct tcacacagac tgatgtggct accttctcag aattaacagg   1080

ggatgtcaat cctttgcatt tgaatgaaga ctttgcaaaa cacaccaagt ttggaaatac   1140

aattgtacat ggagttttga tcaacggact tatctcagct ctcctaggaa ctaaaatgcc   1200

agggccaggc tgtgtatttc tttcccagga aattagcttt ccagcccctt tatatattgg   1260

agaagttgtt ttagcttctg cagaagtgaa aaagctgaag cggttcattg ctattattgc   1320

agtgtcatgt tctgtaatag aaagtaaaaa gactgttatg gaaggctggg ttaaagttat   1380

ggttccagaa gcttccaaat cctgaaatag atgttttaaa gatgcaacct caaacaccaa   1440

tgctgttgtt aaagagccta tggggaattg ctgctcttta ccaaagaatg gttgataggc   1500

ccagaagccc atcttagtta ggggaaggga gcaggaagag ggttgttcaa atgcccactt   1560

tccagtttgg ccttatgctt catgcagact tgagtgtatg caggatttca ttatctgcct   1620

gggttttttg tttgtttttt gttttttaat tcaagaagta ggctgggccc ggtggctcat   1680

gcctgtaatc ctggcacttt gggaggctgc ggcaggcgga tcacttgagg tcaggagtcc   1740

aagaccagcc tggccaacat ggtgaaaccc catctctacc aaaaaaaaaa aaaaaaaaaa   1800

agtgcaacta gctgtgcttg gtgacttggc cctgtagtcc cagttgcttg ggaggctgag   1860

gtgggagaat tgcttgggcc tgagagctgg aggttatggt gagaaactga gattgcacca   1920

ctgcactgta gcctgagtga cagagcgaga ccctgtctca agaaagaagt attgggaagg   1980

ttatttaaag actctacttt taaatcaggc gtggcagctc acgcctgtaa tcccagcatt   2040

ttgggaggct gaggcaggcg aatcacttga ggtcaggagt tcaagaccag cctggccaac   2100

atgtgaaacc ccatctctac taaaaataca aaaactaacc gggcatggtg gcgggcacct   2160

gtaatcccag ctacttggga ggctgaggca ggagaatctc ttgaacctgg gaggttgcag   2220

tgagctgaaa tcacaccact gcacttcagc ctgggtgaca gagcaaaact ccacctcaaa   2280

aaaaaaaaaa agattctact tttagaaatt cagacctaga tagatttgca tttggataac   2340

aaatccctac ctatagccat gtggaagcag cttgtcactg tattttaact gtgtaacaat   2400

tattgaaggc gaaaatagaa gttgggtcat ctttgaacac ctacctttta tcaatgaata   2460

tttttagact gttcttcagt atctgagtca gagtttattg taatttgtta tttacaccaa   2520

ggtggcatct tagtctacct tcagtgagac ttgcgtttca ggggaggggc gtatgtgcat   2580

cctcggtctc agttatgtaa acggtctgat ctgtaaaata gtggtagcac atgccatgtg   2640

ggatagttgg tggagatgat agatggagtt aagcacaggg cccagcctgt cagcagtagc   2700

tactattatt gttgcccatt tcccctgcaa ctgaggtgag aggttttcct gagtttgaag   2760

ctgactggcc cacagttaaa cgtaacagac cagtttttca gggtgtcagc caacctctat   2820

tagtgttctt aagtacagtt tctgttataa aagttcagat tattccttga aaatttggat   2880

ctacctccca ttattatgag taatacatgc ttatagtaaa aaaaaaaaaa ttgtaagaaa   2940

taaatattaa gaagattatg gaggccaaat tcttaagact ttgggggctg gggtcaggga   3000

ggttatattg aaggggagat gtgcctaaca tgttactact aaatggccat cccaacacag   3060

ccaacacttt tgtttcccat ttttttttgt ttcccgtttt ttaataaaat tgagatataa   3120

ttcacatacc ataaaattca ccttttaaaa gtgtacagtt tagtggtttt cagaatatcc   3180

acaaagttgt acaaccatca ccaaatcaat tttttatagc atttttcatc acccccaaaa   3240

gaacctccca ttagcagtca atccatttct ctcctccagt ctttgggaat caccagtcta   3300

ctttctgtct ctatgggttt ccctgttctg gacatttcat aaaagttcat acaatgtatg   3360

atcctttgga actggcttct ttgatatagc atgttttcag ggttcatcca tgttacagca   3420

tgtatcagta catcatttta ttttatggct gaataatatt ccattgtatt tacccat      3477


<210>  9501
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  9501

Met Pro Ala Pro Ala Ala Thr Tyr Glu Arg Val Val Tyr Lys Asn Pro 
1               5                   10                  15      


Ser Glu Tyr His Tyr Met Lys Val Cys Leu Glu Phe Gln Asp Cys Gly 
            20                  25                  30          


Val Gly Leu Asn Ala Ala Gln Phe Lys Gln Leu Leu Ile Ser Ala Val 
        35                  40                  45              


Lys Asp Leu Phe Gly Glu Val Asp Ala Ala Leu Pro Leu Asp Ile Leu 
    50                  55                  60                  


Thr Tyr Glu Glu Lys Thr Leu Ser Ala Ile Leu Arg Ile Cys Ser Ser 
65                  70                  75                  80  


Gly Leu Val Lys Leu Trp Ser Ser Leu Thr Leu Leu Gly Ser Tyr Lys 
                85                  90                  95      


Gly Lys Lys Cys Ala Phe Arg Val Ile Gln Val Ser Pro Phe Leu Leu 
            100                 105                 110         


Ala Leu Ser Gly Asn Ser Arg Glu Leu Val Leu Asp 
        115                 120                 


<210>  9502
<211>  1136
<212>  DNA
<213>  Homosapiens

<400>  9502
gtggggcggg acgaggagaa gccaaacgta aagacaccag gagtttctcg ggcccagctg     60

tggctgctgc cggggagccc caagccttgg cgggtccttg cggcgaatag gagtctggtc    120

aggcgtcagg ctagtccgac gaagagtggg tgtgatcagc actggaaaag atgcctgccc    180

ctgctgccac atatgaaaga gtagtttaca aaaacccttc cgagtaccac tacatgaaag    240

tctgcctaga atttcaagat tgtggagttg gactgaatgc tgcacagttc aaacagctgc    300

ttatttcggc tgtgaaggac ctgtttgggg aggttgatgc cgccttacct ttggacatcc    360

taacctatga agagaagacc ttgtcagcca tcttgagaat atgtagcagt ggtcttgtca    420

aattgtggag ctctttgacc ctgttaggat cctataaagg caaaaaatgt gctttccggg    480

tgattcaggt ttctccattt cttcttgcat tatctggtaa tagtagggaa ctagtattgg    540

attgaatgaa tagtcttcca ttttggaaac gttcatccac tctcatattt attttttggt    600

gcctgcatgt ttgaagactg aagcaggcta aaagctcttg atgaaatttg agggtgctga    660

agatgttccc actaatttcc agccatcacc tttggtgggg tgggcttcgg aggacagtct    720

gtctgaacct gccagtgctg accctgcagc actttcagca tatgcacatc aaagttggag    780

accgcgctga acttaggagg gccttcacac agactgatgt ggctaccttc tcagaattaa    840

caggggatgt caatcctttg catttgaatg aagactttgc aaaacacacc aagtttggaa    900

atacaattgt acatggagtt ttgatcaacg gacttatctc agctctccta ggaactaaaa    960

tgccagggcc aggctgtgta tttctttccc aggaaattag ctttccagcc cctttatata   1020

ttggagaagt tgttttagct tctgcagaag tgaaaaagct gaagcggttc attgctatta   1080

ttgcagtgtc atgttctgta atagaaagta aaaagactgt tatggaaggc tgggtt       1136


<210>  9503
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  9503

Met Pro Ala Pro Ala Ala Thr Tyr Glu Arg Val Val Tyr Lys Asn Pro 
1               5                   10                  15      


Ser Glu Tyr His Tyr Met Lys Val Cys Leu Glu Phe Gln Asp Cys Gly 
            20                  25                  30          


Val Gly Leu Asn Ala Ala Gln Phe Lys Gln Leu Leu Ile Ser Ala Val 
        35                  40                  45              


Lys Asp Leu Phe Gly Glu Val Asp Ala Ala Leu Pro Leu Asp Ile Leu 
    50                  55                  60                  


Thr Tyr Glu Glu Lys Thr Leu Ser Ala Ile Leu Arg Ile Cys Ser Ser 
65                  70                  75                  80  


Gly Leu Val Lys Leu Trp Ser Ser Leu Thr Leu Leu Gly Ser Tyr Lys 
                85                  90                  95      


Gly Lys Lys Cys Ala Phe Arg Val Ile Gln Val Ser Pro Phe Leu Leu 
            100                 105                 110         


Ala Leu Ser Gly Asn Ser Arg Glu Leu Val Leu Asp 
        115                 120                 


<210>  9504
<211>  1544
<212>  DNA
<213>  Homosapiens

<400>  9504
gtggggcggg acgaggagaa gccaaacgta aagacaccag gagtttctcg ggcccagctg     60

tggctgctgc cggggagccc caagccttgg cgggtccttg cggcgaatag gagtctggtc    120

aggcgtcagg ctagtccgac gaagagtggg tgtgatcagc actggaaaag atgcctgccc    180

ctgctgccac atatgaaaga gtagtttaca aaaacccttc cgagtaccac tacatgaaag    240

tctgcctaga atttcaagat tgtggagttg gactgaatgc tgcacagttc aaacagctgc    300

ttatttcggc tgtgaaggac ctgtttgggg aggttgatgc cgccttacct ttggacatcc    360

taacctatga agagaagacc ttgtcagcca tcttgagaat atgtagcagt ggtcttgtca    420

aattgtggag ctctttgacc ctgttaggat cctataaagg caaaaaatgt gctttccggg    480

tgattcaggt ttctccattt cttcttgcat tatctggtaa tagtagggaa ctagtattgg    540

attgaatgaa tagtcttcca ttttggaaac gttcatccac tctcatattt attttttggt    600

gcctgcatgt ttgaagactg aagcaggcta aaagctcttg atgaaatttg agggtgctga    660

agatgttccc actaatttcc agccatcacc tttggtgggg tgggcttcgg aggacagtct    720

gtctgaacct gccagtgctg accctgcagc actttcagca tatgcacatc aaagttggag    780

accgcgctga acttaggagg gccttcacac agactgatgt ggctaccttc tcagaattaa    840

caggggatgt caatcctttg catttgaatg aagactttgc aaaacacacc aagtttggaa    900

atacaattgt acatggagtt ttgatcaacg gacttatctc agctctccta ggaactaaaa    960

tgccagggcc aggctgtgta tttctttccc aggaaattag ctttccagcc cctttatata   1020

ttggagaagt tgttttagct tctgcagaag tgaaaaagct gaagcggttc attgctatta   1080

ttgcagtgtc atgttctgta atagaaagta aaaagactgt tatggaaggc tgggttaaag   1140

ttatggttcc agaagcttcc aaatcctgaa atagatgttt taaagatgca acctcaaaca   1200

ccaatgctgt tgttaaagag cctatgggga attgctgctc tttaccaaag aatggttgat   1260

aggcccagaa gcccatctta gttaggggaa gggagcagga agagggttgt tcaaatgccc   1320

actttccagt ttggccttat gcttcatgca gacttgagtg tatgcaggat ttcattatct   1380

gcctgggttt tttgtttgtt ttttgttttt taattcaaga agtaggctgg gcccggtggc   1440

tcatgcctgt aatcctggca ctttgggagg ctgcggcagg cggatcactt gaggtcagga   1500

gtccaagacc agcctggcca acatggtgaa accccatctc tacc                    1544


<210>  9505
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  9505

Met Pro Ala Pro Ala Ala Thr Tyr Glu Arg Val Val Tyr Lys Asn Pro 
1               5                   10                  15      


Ser Glu Tyr His Tyr Met Lys Val Cys Leu Glu Phe Gln Asp Cys Gly 
            20                  25                  30          


Val Gly Leu Asn Ala Ala Gln Phe Lys Gln Leu Leu Ile Ser Ala Val 
        35                  40                  45              


Lys Asp Leu Phe Gly Glu Val Asp Ala Ala Leu Pro Leu Asp Ile Leu 
    50                  55                  60                  


Thr Tyr Glu Glu Lys Thr Leu Ser Ala Ile Leu Arg Ile Cys Ser Ser 
65                  70                  75                  80  


Gly Leu Val Lys Leu Trp Ser Ser Leu Thr Leu Leu Gly Ser Tyr Lys 
                85                  90                  95      


Gly Lys Lys Cys Ala Phe Arg Val Ile Gln Val Ser Pro Phe Leu Leu 
            100                 105                 110         


Ala Leu Ser Gly Asn Ser Arg Glu Leu Val Leu Asp 
        115                 120                 


<210>  9506
<211>  2721
<212>  DNA
<213>  Homosapiens

<400>  9506
gtggggcggg acgaggagaa gccaaacgta aagacaccag gagtttctcg ggcccagctg     60

tggctgctgc cggggagccc caagccttgg cgggtccttg cggcgaatag gagtctggtc    120

aggcgtcagg ctagtccgac gaagagtggg tgtgatcagc actggaaaag atgcctgccc    180

ctgctgccac atatgaaaga gtagtttaca aaaacccttc cgagtaccac tacatgaaag    240

tctgcctaga atttcaagat tgtggagttg gactgaatgc tgcacagttc aaacagctgc    300

ttatttcggc tgtgaaggac ctgtttgggg aggttgatgc cgccttacct ttggacatcc    360

taacctatga agagaagacc ttgtcagcca tcttgagaat atgtagcagt ggtcttgtca    420

aattgtggag ctctttgacc ctgttaggat cctataaagg caaaaaatgt gctttccggg    480

tgattcaggt ttctccattt cttcttgcat tatctggtaa tagtagggaa ctagtattgg    540

attgaatgaa tagtcttcca ttttggaaac gttcatccac tctcatattt attttttggt    600

gcctgcatgt ttgaagactg aagcaggcta aaagctcttg atgaaatttg agggtgctga    660

agatgttccc actaatttcc agccatcacc tttggtgggg tgggcttcgg aggacagtct    720

gtctgaacct gccagtgctg accctgcagc actttcagca tatgcacatc aaagttggag    780

accgcgctga acttaggagg gccttcacac agactgatgt ggctaccttc tcagaattaa    840

caggggatgt caatcctttg catttgaatg aagactttgc aaaacacacc aagtttggaa    900

atacaattgt acatggagtt ttgatcaacg gacttatctc agctctccta ggaactaaaa    960

tgccagggcc aggctgtgta tttctttccc aggaaattag ctttccagcc cctttatata   1020

ttggagaagt tgttttagct tctgcagaag tgaaaaagct gaagcggttc attgctatta   1080

ttgcagtgtc atgttctgta atagaaagta aaaagactgt tatggaaggc tgggttaaag   1140

ttatggttcc agaagcttcc aaatcctgaa atagatgttt taaagatgca acctcaaaca   1200

ccaatgctgt tgttaaagag cctatgggga attgctgctc tttaccaaag aatggttgat   1260

aggcccagaa gcccatctta gttaggggaa gggagcagga agagggttgt tcaaatgccc   1320

actttccagt ttggccttat gcttcatgca gacttgagtg tatgcaggat ttcattatct   1380

gcctgggttt tttgtttgtt ttttgttttt taattcaaga agtaggctgg gcccggtggc   1440

tcatgcctgt aatcctggca ctttgggagg ctgcggcagg cggatcactt gaggtcagga   1500

gtccaagacc agcctggcca acatggtgaa accccatctc taccaaaaaa aaaaaaaaaa   1560

aaaaagtgca actagctgtg cttggtgact tggccctgta gtcccagttg cttgggaggc   1620

tgaggtggga gaattgcttg ggcctgagag ctggaggtta tggtgagaaa ctgagattgc   1680

accactgcac tgtagcctga gtgacagagc gagaccctgt ctcaagaaag aagtattggg   1740

aaggttattt aaagactcta cttttaaatc aggcgtggca gctcacgcct gtaatcccag   1800

cattttggga ggctgaggca ggcgaatcac ttgaggtcag gagttcaaga ccagcctggc   1860

caacatgtga aaccccatct ctactaaaaa tacaaaaact aaccgggcat ggtggcgggc   1920

acctgtaatc ccagctactt gggaggctga ggcaggagaa tctcttgaac ctgggaggtt   1980

gcagtgagct gaaatcacac cactgcactt cagcctgggt gacagagcaa aactccacct   2040

caaaaaaaaa aaaaagattc tacttttaga aattcagacc tagatagatt tgcatttgga   2100

taacaaatcc ctacctatag ccatgtggaa gcagcttgtc actgtatttt aactgtgtaa   2160

caattattga aggcgaaaat agaagttggg tcatctttga acacctacct tttatcaatg   2220

aatattttta gactgttctt cagtatctga gtcagagttt attgtaattt gttatttaca   2280

ccaaggtggc atcttagtct accttcagtg agacttgcgt ttcaggggag gggcgtatgt   2340

gcatcctcgg tctcagttat gtaaacggtc tgatctgtaa aatagtggta gcacatgcca   2400

tgtgggatag ttggtggaga tgatagatgg agttaagcac agggcccagc ctgtcagcag   2460

tagctactat tattgttgcc catttcccct gcaactgagg tgagaggttt tcctgagttt   2520

gaagctgact ggcccacagt taaacgtaac agaccagttt ttcagggtgt cagccaacct   2580

ctattagtgt tcttaagtac agtttctgtt ataaaagttc agattattcc ttgaaaattt   2640

ggatctacct cccattatta tgagtaatac atgcttatag taaaaaaaaa aaaattgtaa   2700

gaaataaata ttaagaagat t                                             2721


<210>  9507
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  9507

Met Pro Ala Pro Ala Ala Thr Tyr Glu Arg Val Val Tyr Lys Asn Pro 
1               5                   10                  15      


Ser Glu Tyr His Tyr Met Lys Val Cys Leu Glu Phe Gln Asp Cys Gly 
            20                  25                  30          


Val Gly Leu Asn Ala Ala Gln Phe Lys Gln Leu Leu Ile Ser Ala Val 
        35                  40                  45              


Lys Asp Leu Phe Gly Glu Val Asp Ala Ala Leu Pro Leu Asp Ile Leu 
    50                  55                  60                  


Thr Tyr Glu Glu Lys Thr Leu Ser Ala Ile Leu Arg Ile Cys Ser Ser 
65                  70                  75                  80  


Gly Leu Val Lys Leu Trp Ser Ser Leu Thr Leu Leu Gly Ser Tyr Lys 
                85                  90                  95      


Gly Lys Lys Cys Ala Phe Arg Val Ile Gln Val Ser Pro Phe Leu Leu 
            100                 105                 110         


Ala Leu Ser Gly Asn Ser Arg Glu Leu Val Leu Asp 
        115                 120                 


<210>  9508
<211>  3241
<212>  DNA
<213>  Homosapiens

<400>  9508
gtggggcggg acgaggagaa gccaaacgta aagacaccag gagtttctcg ggcccagctg     60

tggctgctgc cggggagccc caagccttgg cgggtccttg cggcgaatag gagtctggtc    120

aggcgtcagg ctagtccgac gaagagtggg tgtgatcagc actggaaaag atgcctgccc    180

ctgctgccac atatgaaaga gtagtttaca aaaacccttc cgagtaccac tacatgaaag    240

tctgcctaga atttcaagat tgtggagttg gactgaatgc tgcacagttc aaacagctgc    300

ttatttcggc tgtgaaggac ctgtttgggg aggttgatgc cgccttacct ttggacatcc    360

taacctatga agagaagacc ttgtcagcca tcttgagaat atgtagcagt ggtcttgtca    420

aattgtggag ctctttgacc ctgttaggat cctataaagg caaaaaatgt gctttccggg    480

tgattcaggt ttctccattt cttcttgcat tatctggtaa tagtagggaa ctagtattgg    540

attgaatgaa tagtcttcca ttttggaaac gttcatccac tctcatattt attttttggt    600

gcctgcatgt ttgaagactg aagcaggcta aaagctcttg atgaaatttg agggtgctga    660

agatgttccc actaatttcc agccatcacc tttggtgggg tgggcttcgg aggacagtct    720

gtctgaacct gccagtgctg accctgcagc actttcagca tatgcacatc aaagttggag    780

accgcgctga acttaggagg gccttcacac agactgatgt ggctaccttc tcagaattaa    840

caggggatgt caatcctttg catttgaatg aagactttgc aaaacacacc aagtttggaa    900

atacaattgt acatggagtt ttgatcaacg gacttatctc agctctccta ggaactaaaa    960

tgccagggcc aggctgtgta tttctttccc aggaaattag ctttccagcc cctttatata   1020

ttggagaagt tgttttagct tctgcagaag tgaaaaagct gaagcggttc attgctatta   1080

ttgcagtgtc atgttctgta atagaaagta aaaagactgt tatggaaggc tgggttaaag   1140

ttatggttcc agaagcttcc aaatcctgaa atagatgttt taaagatgca acctcaaaca   1200

ccaatgctgt tgttaaagag cctatgggga attgctgctc tttaccaaag aatggttgat   1260

aggcccagaa gcccatctta gttaggggaa gggagcagga agagggttgt tcaaatgccc   1320

actttccagt ttggccttat gcttcatgca gacttgagtg tatgcaggat ttcattatct   1380

gcctgggttt tttgtttgtt ttttgttttt taattcaaga agtaggctgg gcccggtggc   1440

tcatgcctgt aatcctggca ctttgggagg ctgcggcagg cggatcactt gaggtcagga   1500

gtccaagacc agcctggcca acatggtgaa accccatctc taccaaaaaa aaaaaaaaaa   1560

aaaaagtgca actagctgtg cttggtgact tggccctgta gtcccagttg cttgggaggc   1620

tgaggtggga gaattgcttg ggcctgagag ctggaggtta tggtgagaaa ctgagattgc   1680

accactgcac tgtagcctga gtgacagagc gagaccctgt ctcaagaaag aagtattggg   1740

aaggttattt aaagactcta cttttaaatc aggcgtggca gctcacgcct gtaatcccag   1800

cattttggga ggctgaggca ggcgaatcac ttgaggtcag gagttcaaga ccagcctggc   1860

caacatgtga aaccccatct ctactaaaaa tacaaaaact aaccgggcat ggtggcgggc   1920

acctgtaatc ccagctactt gggaggctga ggcaggagaa tctcttgaac ctgggaggtt   1980

gcagtgagct gaaatcacac cactgcactt cagcctgggt gacagagcaa aactccacct   2040

caaaaaaaaa aaaaagattc tacttttaga aattcagacc tagatagatt tgcatttgga   2100

taacaaatcc ctacctatag ccatgtggaa gcagcttgtc actgtatttt aactgtgtaa   2160

caattattga aggcgaaaat agaagttggg tcatctttga acacctacct tttatcaatg   2220

aatattttta gactgttctt cagtatctga gtcagagttt attgtaattt gttatttaca   2280

ccaaggtggc atcttagtct accttcagtg agacttgcgt ttcaggggag gggcgtatgt   2340

gcatcctcgg tctcagttat gtaaacggtc tgatctgtaa aatagtggta gcacatgcca   2400

tgtgggatag ttggtggaga tgatagatgg agttaagcac agggcccagc ctgtcagcag   2460

tagctactat tattgttgcc catttcccct gcaactgagg tgagaggttt tcctgagttt   2520

gaagctgact ggcccacagt taaacgtaac agaccagttt ttcagggtgt cagccaacct   2580

ctattagtgt tcttaagtac agtttctgtt ataaaagttc agattattcc ttgaaaattt   2640

ggatctacct cccattatta tgagtaatac atgcttatag taaaaaaaaa aaaattgtaa   2700

gaaataaata ttaagaagat tatggaggcc aaattcttaa gactttgggg gctggggtca   2760

gggaggttat attgaagggg agatgtgcct aacatgttac tactaaatgg ccatcccaac   2820

acagccaaca cttttgtttc ccattttttt ttgtttcccg ttttttaata aaattgagat   2880

ataattcaca taccataaaa ttcacctttt aaaagtgtac agtttagtgg ttttcagaat   2940

atccacaaag ttgtacaacc atcaccaaat caatttttta tagcattttt catcaccccc   3000

aaaagaacct cccattagca gtcaatccat ttctctcctc cagtctttgg gaatcaccag   3060

tctactttct gtctctatgg gtttccctgt tctggacatt tcataaaagt tcatacaatg   3120

tatgatcctt tggaactggc ttctttgata tagcatgttt tcagggttca tccatgttac   3180

agcatgtatc agtacatcat tttattttat ggctgaataa tattccattg tatttaccca   3240

t                                                                   3241


<210>  9509
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  9509

Met Pro Ala Pro Ala Ala Thr Tyr Glu Arg Val Val Tyr Lys Asn Pro 
1               5                   10                  15      


Ser Glu Tyr His Tyr Met Lys Val Cys Leu Glu Phe Gln Asp Cys Gly 
            20                  25                  30          


Val Gly Leu Asn Ala Ala Gln Phe Lys Gln Leu Leu Ile Ser Ala Val 
        35                  40                  45              


Lys Asp Leu Phe Gly Glu Val Asp Ala Ala Leu Pro Leu Asp Ile Leu 
    50                  55                  60                  


Thr Tyr Glu Glu Lys Thr Leu Ser Ala Ile Leu Arg Ile Cys Ser Ser 
65                  70                  75                  80  


Gly Leu Val Lys Leu Trp Ser Ser Leu Thr Leu Leu Gly Ser Tyr Lys 
                85                  90                  95      


Gly Lys Lys Cys Ala Phe Arg Val Ile Gln Val Ser Pro Phe Leu Leu 
            100                 105                 110         


Ala Leu Ser Gly Asn Ser Arg Glu Leu Val Leu Asp 
        115                 120                 


<210>  9510
<211>  1128
<212>  DNA
<213>  Homosapiens

<400>  9510
ggacgaggag aagccaaacg taaagacacc aggagtttct cgggcccagc tgtggctgct     60

gccggggagc cccaagcctt ggcgggtcct tgcggcgaat aggagtctgg tcaggcgtca    120

ggctagtccg acgaagagtg gagaatttca agattgtgga gttggactga atgctgcaca    180

gttcaaacag ctgcttattt cggctgtgaa ggacctgttt ggggaggctg gagtgcaatg    240

gcacgatctt ggctcaccgc accctccgcc tcccaggttc aagcgattct cctgcctcag    300

cctcgcaagt agctgggatt acaggttgat gccgccttac ctttggacat cctaacctat    360

gaagagaaga ccttgtcagc catcttgaga atatgtagca gtggtcttgt caaattgtgg    420

agctctttga ccctgttagg atcctataaa ggcaaaaaat gtgctttccg ggtgattcag    480

gtttctccat ttcttcttgc attatctggt aatagtaggg aactagtatt ggattgaatg    540

aatagtcttc cattttggaa acgttcatcc actctcatat ttattttttg gtgcctgcat    600

gtttgaagac tgaagcaggc taaaagctct tgatgaaatt tgagggtgct gaagatgttc    660

ccactaattt ccagccatca cctttggtgg ggtgggcttc ggaggacagt ctgtctgaac    720

ctgccagtgc tgaccctgca gcactttcag catatgcaca tcaaagttgg agaccgcgct    780

gaacttagga gggccttcac acagactgat gtggctacct tctcagaatt aacaggggat    840

gtcaatcctt tgcatttgaa tgaagacttt gcaaaacaca ccaagtttgg aaatacaatt    900

gtacatggag ttttgatcaa cggacttatc tcagctctcc taggaactaa aatgccaggg    960

ccaggctgtg tatttctttc ccaggaaatt agctttccag cccctttata tattggagaa   1020

gttgttttag cttctgcaga agtgaaaaag ctgaagcggt tcattgctat tattgcagtg   1080

tcatgttctg taatagaaag taaaaagact gttatggaag gctgggtt                1128


<210>  9511
<211>  157
<212>  PRT
<213>  Homosapiens

<400>  9511

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp 
145                 150                 155         


<210>  9512
<211>  2713
<212>  DNA
<213>  Homosapiens

<400>  9512
ggacgaggag aagccaaacg taaagacacc aggagtttct cgggcccagc tgtggctgct     60

gccggggagc cccaagcctt ggcgggtcct tgcggcgaat aggagtctgg tcaggcgtca    120

ggctagtccg acgaagagtg gagaatttca agattgtgga gttggactga atgctgcaca    180

gttcaaacag ctgcttattt cggctgtgaa ggacctgttt ggggaggctg gagtgcaatg    240

gcacgatctt ggctcaccgc accctccgcc tcccaggttc aagcgattct cctgcctcag    300

cctcgcaagt agctgggatt acaggttgat gccgccttac ctttggacat cctaacctat    360

gaagagaaga ccttgtcagc catcttgaga atatgtagca gtggtcttgt caaattgtgg    420

agctctttga ccctgttagg atcctataaa ggcaaaaaat gtgctttccg ggtgattcag    480

gtttctccat ttcttcttgc attatctggt aatagtaggg aactagtatt ggattgaatg    540

aatagtcttc cattttggaa acgttcatcc actctcatat ttattttttg gtgcctgcat    600

gtttgaagac tgaagcaggc taaaagctct tgatgaaatt tgagggtgct gaagatgttc    660

ccactaattt ccagccatca cctttggtgg ggtgggcttc ggaggacagt ctgtctgaac    720

ctgccagtgc tgaccctgca gcactttcag catatgcaca tcaaagttgg agaccgcgct    780

gaacttagga gggccttcac acagactgat gtggctacct tctcagaatt aacaggggat    840

gtcaatcctt tgcatttgaa tgaagacttt gcaaaacaca ccaagtttgg aaatacaatt    900

gtacatggag ttttgatcaa cggacttatc tcagctctcc taggaactaa aatgccaggg    960

ccaggctgtg tatttctttc ccaggaaatt agctttccag cccctttata tattggagaa   1020

gttgttttag cttctgcaga agtgaaaaag ctgaagcggt tcattgctat tattgcagtg   1080

tcatgttctg taatagaaag taaaaagact gttatggaag gctgggttaa agttatggtt   1140

ccagaagctt ccaaatcctg aaatagatgt tttaaagatg caacctcaaa caccaatgct   1200

gttgttaaag agcctatggg gaattgctgc tctttaccaa agaatggttg ataggcccag   1260

aagcccatct tagttagggg aagggagcag gaagagggtt gttcaaatgc ccactttcca   1320

gtttggcctt atgcttcatg cagacttgag tgtatgcagg atttcattat ctgcctgggt   1380

tttttgtttg ttttttgttt tttaattcaa gaagtaggct gggcccggtg gctcatgcct   1440

gtaatcctgg cactttggga ggctgcggca ggcggatcac ttgaggtcag gagtccaaga   1500

ccagcctggc caacatggtg aaaccccatc tctaccaaaa aaaaaaaaaa aaaaaaagtg   1560

caactagctg tgcttggtga cttggccctg tagtcccagt tgcttgggag gctgaggtgg   1620

gagaattgct tgggcctgag agctggaggt tatggtgaga aactgagatt gcaccactgc   1680

actgtagcct gagtgacaga gcgagaccct gtctcaagaa agaagtattg ggaaggttat   1740

ttaaagactc tacttttaaa tcaggcgtgg cagctcacgc ctgtaatccc agcattttgg   1800

gaggctgagg caggcgaatc acttgaggtc aggagttcaa gaccagcctg gccaacatgt   1860

gaaaccccat ctctactaaa aatacaaaaa ctaaccgggc atggtggcgg gcacctgtaa   1920

tcccagctac ttgggaggct gaggcaggag aatctcttga acctgggagg ttgcagtgag   1980

ctgaaatcac accactgcac ttcagcctgg gtgacagagc aaaactccac ctcaaaaaaa   2040

aaaaaaagat tctactttta gaaattcaga cctagataga tttgcatttg gataacaaat   2100

ccctacctat agccatgtgg aagcagcttg tcactgtatt ttaactgtgt aacaattatt   2160

gaaggcgaaa atagaagttg ggtcatcttt gaacacctac cttttatcaa tgaatatttt   2220

tagactgttc ttcagtatct gagtcagagt ttattgtaat ttgttattta caccaaggtg   2280

gcatcttagt ctaccttcag tgagacttgc gtttcagggg aggggcgtat gtgcatcctc   2340

ggtctcagtt atgtaaacgg tctgatctgt aaaatagtgg tagcacatgc catgtgggat   2400

agttggtgga gatgatagat ggagttaagc acagggccca gcctgtcagc agtagctact   2460

attattgttg cccatttccc ctgcaactga ggtgagaggt tttcctgagt ttgaagctga   2520

ctggcccaca gttaaacgta acagaccagt ttttcagggt gtcagccaac ctctattagt   2580

gttcttaagt acagtttctg ttataaaagt tcagattatt ccttgaaaat ttggatctac   2640

ctcccattat tatgagtaat acatgcttat agtaaaaaaa aaaaaattgt aagaaataaa   2700

tattaagaag att                                                      2713


<210>  9513
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  9513

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp Val Lys Val 
145                 150                 155                 160 


Met Val Pro Glu Ala Ser Lys Ser 
                165             


<210>  9514
<211>  3233
<212>  DNA
<213>  Homosapiens

<400>  9514
ggacgaggag aagccaaacg taaagacacc aggagtttct cgggcccagc tgtggctgct     60

gccggggagc cccaagcctt ggcgggtcct tgcggcgaat aggagtctgg tcaggcgtca    120

ggctagtccg acgaagagtg gagaatttca agattgtgga gttggactga atgctgcaca    180

gttcaaacag ctgcttattt cggctgtgaa ggacctgttt ggggaggctg gagtgcaatg    240

gcacgatctt ggctcaccgc accctccgcc tcccaggttc aagcgattct cctgcctcag    300

cctcgcaagt agctgggatt acaggttgat gccgccttac ctttggacat cctaacctat    360

gaagagaaga ccttgtcagc catcttgaga atatgtagca gtggtcttgt caaattgtgg    420

agctctttga ccctgttagg atcctataaa ggcaaaaaat gtgctttccg ggtgattcag    480

gtttctccat ttcttcttgc attatctggt aatagtaggg aactagtatt ggattgaatg    540

aatagtcttc cattttggaa acgttcatcc actctcatat ttattttttg gtgcctgcat    600

gtttgaagac tgaagcaggc taaaagctct tgatgaaatt tgagggtgct gaagatgttc    660

ccactaattt ccagccatca cctttggtgg ggtgggcttc ggaggacagt ctgtctgaac    720

ctgccagtgc tgaccctgca gcactttcag catatgcaca tcaaagttgg agaccgcgct    780

gaacttagga gggccttcac acagactgat gtggctacct tctcagaatt aacaggggat    840

gtcaatcctt tgcatttgaa tgaagacttt gcaaaacaca ccaagtttgg aaatacaatt    900

gtacatggag ttttgatcaa cggacttatc tcagctctcc taggaactaa aatgccaggg    960

ccaggctgtg tatttctttc ccaggaaatt agctttccag cccctttata tattggagaa   1020

gttgttttag cttctgcaga agtgaaaaag ctgaagcggt tcattgctat tattgcagtg   1080

tcatgttctg taatagaaag taaaaagact gttatggaag gctgggttaa agttatggtt   1140

ccagaagctt ccaaatcctg aaatagatgt tttaaagatg caacctcaaa caccaatgct   1200

gttgttaaag agcctatggg gaattgctgc tctttaccaa agaatggttg ataggcccag   1260

aagcccatct tagttagggg aagggagcag gaagagggtt gttcaaatgc ccactttcca   1320

gtttggcctt atgcttcatg cagacttgag tgtatgcagg atttcattat ctgcctgggt   1380

tttttgtttg ttttttgttt tttaattcaa gaagtaggct gggcccggtg gctcatgcct   1440

gtaatcctgg cactttggga ggctgcggca ggcggatcac ttgaggtcag gagtccaaga   1500

ccagcctggc caacatggtg aaaccccatc tctaccaaaa aaaaaaaaaa aaaaaaagtg   1560

caactagctg tgcttggtga cttggccctg tagtcccagt tgcttgggag gctgaggtgg   1620

gagaattgct tgggcctgag agctggaggt tatggtgaga aactgagatt gcaccactgc   1680

actgtagcct gagtgacaga gcgagaccct gtctcaagaa agaagtattg ggaaggttat   1740

ttaaagactc tacttttaaa tcaggcgtgg cagctcacgc ctgtaatccc agcattttgg   1800

gaggctgagg caggcgaatc acttgaggtc aggagttcaa gaccagcctg gccaacatgt   1860

gaaaccccat ctctactaaa aatacaaaaa ctaaccgggc atggtggcgg gcacctgtaa   1920

tcccagctac ttgggaggct gaggcaggag aatctcttga acctgggagg ttgcagtgag   1980

ctgaaatcac accactgcac ttcagcctgg gtgacagagc aaaactccac ctcaaaaaaa   2040

aaaaaaagat tctactttta gaaattcaga cctagataga tttgcatttg gataacaaat   2100

ccctacctat agccatgtgg aagcagcttg tcactgtatt ttaactgtgt aacaattatt   2160

gaaggcgaaa atagaagttg ggtcatcttt gaacacctac cttttatcaa tgaatatttt   2220

tagactgttc ttcagtatct gagtcagagt ttattgtaat ttgttattta caccaaggtg   2280

gcatcttagt ctaccttcag tgagacttgc gtttcagggg aggggcgtat gtgcatcctc   2340

ggtctcagtt atgtaaacgg tctgatctgt aaaatagtgg tagcacatgc catgtgggat   2400

agttggtgga gatgatagat ggagttaagc acagggccca gcctgtcagc agtagctact   2460

attattgttg cccatttccc ctgcaactga ggtgagaggt tttcctgagt ttgaagctga   2520

ctggcccaca gttaaacgta acagaccagt ttttcagggt gtcagccaac ctctattagt   2580

gttcttaagt acagtttctg ttataaaagt tcagattatt ccttgaaaat ttggatctac   2640

ctcccattat tatgagtaat acatgcttat agtaaaaaaa aaaaaattgt aagaaataaa   2700

tattaagaag attatggagg ccaaattctt aagactttgg gggctggggt cagggaggtt   2760

atattgaagg ggagatgtgc ctaacatgtt actactaaat ggccatccca acacagccaa   2820

cacttttgtt tcccattttt ttttgtttcc cgttttttaa taaaattgag atataattca   2880

cataccataa aattcacctt ttaaaagtgt acagtttagt ggttttcaga atatccacaa   2940

agttgtacaa ccatcaccaa atcaattttt tatagcattt ttcatcaccc ccaaaagaac   3000

ctcccattag cagtcaatcc atttctctcc tccagtcttt gggaatcacc agtctacttt   3060

ctgtctctat gggtttccct gttctggaca tttcataaaa gttcatacaa tgtatgatcc   3120

tttggaactg gcttctttga tatagcatgt tttcagggtt catccatgtt acagcatgta   3180

tcagtacatc attttatttt atggctgaat aatattccat tgtatttacc cat          3233


<210>  9515
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  9515

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp Val Lys Val 
145                 150                 155                 160 


Met Val Pro Glu Ala Ser Lys Ser 
                165             


<210>  9516
<211>  1242
<212>  DNA
<213>  Homosapiens

<400>  9516
aagacaccag gagtttctcg ggcccagctg tggctgctgc cggggagccc caagccttgg     60

cgggtccttg cggcgaatag gagtctggtc aggcgtcagg ctagtccgac gaagagtggg    120

taggtggaag ccttccaaag agcggcggtt gtctgggagc cgtctcagtt ggccgcgacc    180

cgggcgcatg cgcggggcgg gcggtgcgcc ttgggtagct tgtcctctcc gaccccgggc    240

gctgagggcc tctgtacggc gccgcgtagg gtctcggccg cagaacgtgg ccgagaggcc    300

cgggcgagac ttcgggaccg tgtcctgagc gctctccatg cgcccggcgc gagagaattt    360

caagattgtg gagttggact gaatgctgca cagttcaaac agctgcttat ttcggctgtg    420

aaggacctgt ttggggaggt tgatgccgcc ttacctttgg acatcctaac ctatgaagag    480

aagaccttgt cagccatctt gagaatatgt agcagtggtc ttgtcaaatt gtggagctct    540

ttgaccctgt taggatccta taaaggcaaa aaatgtgctt tccgggtgat tcaggtttct    600

ccatttcttc ttgcattatc tggtaatagt agggaactag tattggattg aatgaatagt    660

cttccatttt ggaaacgttc atccactctc atatttattt tttggtgcct gcatgtttga    720

agactgaagc aggctaaaag ctcttgatga aatttgaggg tgctgaagat gttcccacta    780

atttccagcc atcacctttg gtggggtggg cttcggagga cagtctgtct gaacctgcca    840

gtgctgaccc tgcagcactt tcagcatatg cacatcaaag ttggagaccg cgctgaactt    900

aggagggcct tcacacagac tgatgtggct accttctcag aattaacagg ggatgtcaat    960

cctttgcatt tgaatgaaga ctttgcaaaa cacaccaagt ttggaaatac aattgtacat   1020

ggagttttga tcaacggact tatctcagct ctcctaggaa ctaaaatgcc agggccaggc   1080

tgtgtatttc tttcccagga aattagcttt ccagcccctt tatatattgg agaagttgtt   1140

ttagcttctg cagaagtgaa aaagctgaag cggttcattg ctattattgc agtgtcatgt   1200

tctgtaatag aaagtaaaaa gactgttatg gaaggctggg tt                      1242


<210>  9517
<211>  157
<212>  PRT
<213>  Homosapiens

<400>  9517

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp 
145                 150                 155         


<210>  9518
<211>  2827
<212>  DNA
<213>  Homosapiens

<400>  9518
aagacaccag gagtttctcg ggcccagctg tggctgctgc cggggagccc caagccttgg     60

cgggtccttg cggcgaatag gagtctggtc aggcgtcagg ctagtccgac gaagagtggg    120

taggtggaag ccttccaaag agcggcggtt gtctgggagc cgtctcagtt ggccgcgacc    180

cgggcgcatg cgcggggcgg gcggtgcgcc ttgggtagct tgtcctctcc gaccccgggc    240

gctgagggcc tctgtacggc gccgcgtagg gtctcggccg cagaacgtgg ccgagaggcc    300

cgggcgagac ttcgggaccg tgtcctgagc gctctccatg cgcccggcgc gagagaattt    360

caagattgtg gagttggact gaatgctgca cagttcaaac agctgcttat ttcggctgtg    420

aaggacctgt ttggggaggt tgatgccgcc ttacctttgg acatcctaac ctatgaagag    480

aagaccttgt cagccatctt gagaatatgt agcagtggtc ttgtcaaatt gtggagctct    540

ttgaccctgt taggatccta taaaggcaaa aaatgtgctt tccgggtgat tcaggtttct    600

ccatttcttc ttgcattatc tggtaatagt agggaactag tattggattg aatgaatagt    660

cttccatttt ggaaacgttc atccactctc atatttattt tttggtgcct gcatgtttga    720

agactgaagc aggctaaaag ctcttgatga aatttgaggg tgctgaagat gttcccacta    780

atttccagcc atcacctttg gtggggtggg cttcggagga cagtctgtct gaacctgcca    840

gtgctgaccc tgcagcactt tcagcatatg cacatcaaag ttggagaccg cgctgaactt    900

aggagggcct tcacacagac tgatgtggct accttctcag aattaacagg ggatgtcaat    960

cctttgcatt tgaatgaaga ctttgcaaaa cacaccaagt ttggaaatac aattgtacat   1020

ggagttttga tcaacggact tatctcagct ctcctaggaa ctaaaatgcc agggccaggc   1080

tgtgtatttc tttcccagga aattagcttt ccagcccctt tatatattgg agaagttgtt   1140

ttagcttctg cagaagtgaa aaagctgaag cggttcattg ctattattgc agtgtcatgt   1200

tctgtaatag aaagtaaaaa gactgttatg gaaggctggg ttaaagttat ggttccagaa   1260

gcttccaaat cctgaaatag atgttttaaa gatgcaacct caaacaccaa tgctgttgtt   1320

aaagagccta tggggaattg ctgctcttta ccaaagaatg gttgataggc ccagaagccc   1380

atcttagtta ggggaaggga gcaggaagag ggttgttcaa atgcccactt tccagtttgg   1440

ccttatgctt catgcagact tgagtgtatg caggatttca ttatctgcct gggttttttg   1500

tttgtttttt gttttttaat tcaagaagta ggctgggccc ggtggctcat gcctgtaatc   1560

ctggcacttt gggaggctgc ggcaggcgga tcacttgagg tcaggagtcc aagaccagcc   1620

tggccaacat ggtgaaaccc catctctacc aaaaaaaaaa aaaaaaaaaa agtgcaacta   1680

gctgtgcttg gtgacttggc cctgtagtcc cagttgcttg ggaggctgag gtgggagaat   1740

tgcttgggcc tgagagctgg aggttatggt gagaaactga gattgcacca ctgcactgta   1800

gcctgagtga cagagcgaga ccctgtctca agaaagaagt attgggaagg ttatttaaag   1860

actctacttt taaatcaggc gtggcagctc acgcctgtaa tcccagcatt ttgggaggct   1920

gaggcaggcg aatcacttga ggtcaggagt tcaagaccag cctggccaac atgtgaaacc   1980

ccatctctac taaaaataca aaaactaacc gggcatggtg gcgggcacct gtaatcccag   2040

ctacttggga ggctgaggca ggagaatctc ttgaacctgg gaggttgcag tgagctgaaa   2100

tcacaccact gcacttcagc ctgggtgaca gagcaaaact ccacctcaaa aaaaaaaaaa   2160

agattctact tttagaaatt cagacctaga tagatttgca tttggataac aaatccctac   2220

ctatagccat gtggaagcag cttgtcactg tattttaact gtgtaacaat tattgaaggc   2280

gaaaatagaa gttgggtcat ctttgaacac ctacctttta tcaatgaata tttttagact   2340

gttcttcagt atctgagtca gagtttattg taatttgtta tttacaccaa ggtggcatct   2400

tagtctacct tcagtgagac ttgcgtttca ggggaggggc gtatgtgcat cctcggtctc   2460

agttatgtaa acggtctgat ctgtaaaata gtggtagcac atgccatgtg ggatagttgg   2520

tggagatgat agatggagtt aagcacaggg cccagcctgt cagcagtagc tactattatt   2580

gttgcccatt tcccctgcaa ctgaggtgag aggttttcct gagtttgaag ctgactggcc   2640

cacagttaaa cgtaacagac cagtttttca gggtgtcagc caacctctat tagtgttctt   2700

aagtacagtt tctgttataa aagttcagat tattccttga aaatttggat ctacctccca   2760

ttattatgag taatacatgc ttatagtaaa aaaaaaaaaa ttgtaagaaa taaatattaa   2820

gaagatt                                                             2827


<210>  9519
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  9519

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp Val Lys Val 
145                 150                 155                 160 


Met Val Pro Glu Ala Ser Lys Ser 
                165             


<210>  9520
<211>  3347
<212>  DNA
<213>  Homosapiens

<400>  9520
aagacaccag gagtttctcg ggcccagctg tggctgctgc cggggagccc caagccttgg     60

cgggtccttg cggcgaatag gagtctggtc aggcgtcagg ctagtccgac gaagagtggg    120

taggtggaag ccttccaaag agcggcggtt gtctgggagc cgtctcagtt ggccgcgacc    180

cgggcgcatg cgcggggcgg gcggtgcgcc ttgggtagct tgtcctctcc gaccccgggc    240

gctgagggcc tctgtacggc gccgcgtagg gtctcggccg cagaacgtgg ccgagaggcc    300

cgggcgagac ttcgggaccg tgtcctgagc gctctccatg cgcccggcgc gagagaattt    360

caagattgtg gagttggact gaatgctgca cagttcaaac agctgcttat ttcggctgtg    420

aaggacctgt ttggggaggt tgatgccgcc ttacctttgg acatcctaac ctatgaagag    480

aagaccttgt cagccatctt gagaatatgt agcagtggtc ttgtcaaatt gtggagctct    540

ttgaccctgt taggatccta taaaggcaaa aaatgtgctt tccgggtgat tcaggtttct    600

ccatttcttc ttgcattatc tggtaatagt agggaactag tattggattg aatgaatagt    660

cttccatttt ggaaacgttc atccactctc atatttattt tttggtgcct gcatgtttga    720

agactgaagc aggctaaaag ctcttgatga aatttgaggg tgctgaagat gttcccacta    780

atttccagcc atcacctttg gtggggtggg cttcggagga cagtctgtct gaacctgcca    840

gtgctgaccc tgcagcactt tcagcatatg cacatcaaag ttggagaccg cgctgaactt    900

aggagggcct tcacacagac tgatgtggct accttctcag aattaacagg ggatgtcaat    960

cctttgcatt tgaatgaaga ctttgcaaaa cacaccaagt ttggaaatac aattgtacat   1020

ggagttttga tcaacggact tatctcagct ctcctaggaa ctaaaatgcc agggccaggc   1080

tgtgtatttc tttcccagga aattagcttt ccagcccctt tatatattgg agaagttgtt   1140

ttagcttctg cagaagtgaa aaagctgaag cggttcattg ctattattgc agtgtcatgt   1200

tctgtaatag aaagtaaaaa gactgttatg gaaggctggg ttaaagttat ggttccagaa   1260

gcttccaaat cctgaaatag atgttttaaa gatgcaacct caaacaccaa tgctgttgtt   1320

aaagagccta tggggaattg ctgctcttta ccaaagaatg gttgataggc ccagaagccc   1380

atcttagtta ggggaaggga gcaggaagag ggttgttcaa atgcccactt tccagtttgg   1440

ccttatgctt catgcagact tgagtgtatg caggatttca ttatctgcct gggttttttg   1500

tttgtttttt gttttttaat tcaagaagta ggctgggccc ggtggctcat gcctgtaatc   1560

ctggcacttt gggaggctgc ggcaggcgga tcacttgagg tcaggagtcc aagaccagcc   1620

tggccaacat ggtgaaaccc catctctacc aaaaaaaaaa aaaaaaaaaa agtgcaacta   1680

gctgtgcttg gtgacttggc cctgtagtcc cagttgcttg ggaggctgag gtgggagaat   1740

tgcttgggcc tgagagctgg aggttatggt gagaaactga gattgcacca ctgcactgta   1800

gcctgagtga cagagcgaga ccctgtctca agaaagaagt attgggaagg ttatttaaag   1860

actctacttt taaatcaggc gtggcagctc acgcctgtaa tcccagcatt ttgggaggct   1920

gaggcaggcg aatcacttga ggtcaggagt tcaagaccag cctggccaac atgtgaaacc   1980

ccatctctac taaaaataca aaaactaacc gggcatggtg gcgggcacct gtaatcccag   2040

ctacttggga ggctgaggca ggagaatctc ttgaacctgg gaggttgcag tgagctgaaa   2100

tcacaccact gcacttcagc ctgggtgaca gagcaaaact ccacctcaaa aaaaaaaaaa   2160

agattctact tttagaaatt cagacctaga tagatttgca tttggataac aaatccctac   2220

ctatagccat gtggaagcag cttgtcactg tattttaact gtgtaacaat tattgaaggc   2280

gaaaatagaa gttgggtcat ctttgaacac ctacctttta tcaatgaata tttttagact   2340

gttcttcagt atctgagtca gagtttattg taatttgtta tttacaccaa ggtggcatct   2400

tagtctacct tcagtgagac ttgcgtttca ggggaggggc gtatgtgcat cctcggtctc   2460

agttatgtaa acggtctgat ctgtaaaata gtggtagcac atgccatgtg ggatagttgg   2520

tggagatgat agatggagtt aagcacaggg cccagcctgt cagcagtagc tactattatt   2580

gttgcccatt tcccctgcaa ctgaggtgag aggttttcct gagtttgaag ctgactggcc   2640

cacagttaaa cgtaacagac cagtttttca gggtgtcagc caacctctat tagtgttctt   2700

aagtacagtt tctgttataa aagttcagat tattccttga aaatttggat ctacctccca   2760

ttattatgag taatacatgc ttatagtaaa aaaaaaaaaa ttgtaagaaa taaatattaa   2820

gaagattatg gaggccaaat tcttaagact ttgggggctg gggtcaggga ggttatattg   2880

aaggggagat gtgcctaaca tgttactact aaatggccat cccaacacag ccaacacttt   2940

tgtttcccat ttttttttgt ttcccgtttt ttaataaaat tgagatataa ttcacatacc   3000

ataaaattca ccttttaaaa gtgtacagtt tagtggtttt cagaatatcc acaaagttgt   3060

acaaccatca ccaaatcaat tttttatagc atttttcatc acccccaaaa gaacctccca   3120

ttagcagtca atccatttct ctcctccagt ctttgggaat caccagtcta ctttctgtct   3180

ctatgggttt ccctgttctg gacatttcat aaaagttcat acaatgtatg atcctttgga   3240

actggcttct ttgatatagc atgttttcag ggttcatcca tgttacagca tgtatcagta   3300

catcatttta ttttatggct gaataatatt ccattgtatt tacccat                 3347


<210>  9521
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  9521

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp Val Lys Val 
145                 150                 155                 160 


Met Val Pro Glu Ala Ser Lys Ser 
                165             


<210>  9522
<211>  1090
<212>  DNA
<213>  Homosapiens

<400>  9522
taccagtctg tacaaaataa tttcccaggt atcctctcct ttaatgtcag aacagcctgc     60

agagggcagt gctgtcattt gtaagtcttt tttttttttt ttaattgcaa aaaatacgtg    120

acataaaatt tatcgtaagt agcattgagt acattcacaa cgctgtgcag ccatcaccac    180

tgtccatctc gtgaatgttg tagaatttca agattgtgga gttggactga atgctgcaca    240

gttcaaacag ctgcttattt cggctgtgaa ggacctgttt ggggaggttg atgccgcctt    300

acctttggac atcctaacct atgaagagaa gaccttgtca gccatcttga gaatatgtag    360

cagtggtctt gtcaaattgt ggagctcttt gaccctgtta ggatcctata aaggcaaaaa    420

atgtgctttc cgggtgattc aggtttctcc atttcttctt gcattatctg gtaatagtag    480

ggaactagta ttggattgaa tgaatagtct tccattttgg aaacgttcat ccactctcat    540

atttattttt tggtgcctgc atgtttgaag actgaagcag gctaaaagct cttgatgaaa    600

tttgagggtg ctgaagatgt tcccactaat ttccagccat cacctttggt ggggtgggct    660

tcggaggaca gtctgtctga acctgccagt gctgaccctg cagcactttc agcatatgca    720

catcaaagtt ggagaccgcg ctgaacttag gagggccttc acacagactg atgtggctac    780

cttctcagaa ttaacagggg atgtcaatcc tttgcatttg aatgaagact ttgcaaaaca    840

caccaagttt ggaaatacaa ttgtacatgg agttttgatc aacggactta tctcagctct    900

cctaggaact aaaatgccag ggccaggctg tgtatttctt tcccaggaaa ttagctttcc    960

agccccttta tatattggag aagttgtttt agcttctgca gaagtgaaaa agctgaagcg   1020

gttcattgct attattgcag tgtcatgttc tgtaatagaa agtaaaaaga ctgttatgga   1080

aggctgggtt                                                          1090


<210>  9523
<211>  157
<212>  PRT
<213>  Homosapiens

<400>  9523

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp 
145                 150                 155         


<210>  9524
<211>  2675
<212>  DNA
<213>  Homosapiens

<400>  9524
taccagtctg tacaaaataa tttcccaggt atcctctcct ttaatgtcag aacagcctgc     60

agagggcagt gctgtcattt gtaagtcttt tttttttttt ttaattgcaa aaaatacgtg    120

acataaaatt tatcgtaagt agcattgagt acattcacaa cgctgtgcag ccatcaccac    180

tgtccatctc gtgaatgttg tagaatttca agattgtgga gttggactga atgctgcaca    240

gttcaaacag ctgcttattt cggctgtgaa ggacctgttt ggggaggttg atgccgcctt    300

acctttggac atcctaacct atgaagagaa gaccttgtca gccatcttga gaatatgtag    360

cagtggtctt gtcaaattgt ggagctcttt gaccctgtta ggatcctata aaggcaaaaa    420

atgtgctttc cgggtgattc aggtttctcc atttcttctt gcattatctg gtaatagtag    480

ggaactagta ttggattgaa tgaatagtct tccattttgg aaacgttcat ccactctcat    540

atttattttt tggtgcctgc atgtttgaag actgaagcag gctaaaagct cttgatgaaa    600

tttgagggtg ctgaagatgt tcccactaat ttccagccat cacctttggt ggggtgggct    660

tcggaggaca gtctgtctga acctgccagt gctgaccctg cagcactttc agcatatgca    720

catcaaagtt ggagaccgcg ctgaacttag gagggccttc acacagactg atgtggctac    780

cttctcagaa ttaacagggg atgtcaatcc tttgcatttg aatgaagact ttgcaaaaca    840

caccaagttt ggaaatacaa ttgtacatgg agttttgatc aacggactta tctcagctct    900

cctaggaact aaaatgccag ggccaggctg tgtatttctt tcccaggaaa ttagctttcc    960

agccccttta tatattggag aagttgtttt agcttctgca gaagtgaaaa agctgaagcg   1020

gttcattgct attattgcag tgtcatgttc tgtaatagaa agtaaaaaga ctgttatgga   1080

aggctgggtt aaagttatgg ttccagaagc ttccaaatcc tgaaatagat gttttaaaga   1140

tgcaacctca aacaccaatg ctgttgttaa agagcctatg gggaattgct gctctttacc   1200

aaagaatggt tgataggccc agaagcccat cttagttagg ggaagggagc aggaagaggg   1260

ttgttcaaat gcccactttc cagtttggcc ttatgcttca tgcagacttg agtgtatgca   1320

ggatttcatt atctgcctgg gttttttgtt tgttttttgt tttttaattc aagaagtagg   1380

ctgggcccgg tggctcatgc ctgtaatcct ggcactttgg gaggctgcgg caggcggatc   1440

acttgaggtc aggagtccaa gaccagcctg gccaacatgg tgaaacccca tctctaccaa   1500

aaaaaaaaaa aaaaaaaaag tgcaactagc tgtgcttggt gacttggccc tgtagtccca   1560

gttgcttggg aggctgaggt gggagaattg cttgggcctg agagctggag gttatggtga   1620

gaaactgaga ttgcaccact gcactgtagc ctgagtgaca gagcgagacc ctgtctcaag   1680

aaagaagtat tgggaaggtt atttaaagac tctactttta aatcaggcgt ggcagctcac   1740

gcctgtaatc ccagcatttt gggaggctga ggcaggcgaa tcacttgagg tcaggagttc   1800

aagaccagcc tggccaacat gtgaaacccc atctctacta aaaatacaaa aactaaccgg   1860

gcatggtggc gggcacctgt aatcccagct acttgggagg ctgaggcagg agaatctctt   1920

gaacctggga ggttgcagtg agctgaaatc acaccactgc acttcagcct gggtgacaga   1980

gcaaaactcc acctcaaaaa aaaaaaaaag attctacttt tagaaattca gacctagata   2040

gatttgcatt tggataacaa atccctacct atagccatgt ggaagcagct tgtcactgta   2100

ttttaactgt gtaacaatta ttgaaggcga aaatagaagt tgggtcatct ttgaacacct   2160

accttttatc aatgaatatt tttagactgt tcttcagtat ctgagtcaga gtttattgta   2220

atttgttatt tacaccaagg tggcatctta gtctaccttc agtgagactt gcgtttcagg   2280

ggaggggcgt atgtgcatcc tcggtctcag ttatgtaaac ggtctgatct gtaaaatagt   2340

ggtagcacat gccatgtggg atagttggtg gagatgatag atggagttaa gcacagggcc   2400

cagcctgtca gcagtagcta ctattattgt tgcccatttc ccctgcaact gaggtgagag   2460

gttttcctga gtttgaagct gactggccca cagttaaacg taacagacca gtttttcagg   2520

gtgtcagcca acctctatta gtgttcttaa gtacagtttc tgttataaaa gttcagatta   2580

ttccttgaaa atttggatct acctcccatt attatgagta atacatgctt atagtaaaaa   2640

aaaaaaaatt gtaagaaata aatattaaga agatt                              2675


<210>  9525
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  9525

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp Val Lys Val 
145                 150                 155                 160 


Met Val Pro Glu Ala Ser Lys Ser 
                165             


<210>  9526
<211>  3195
<212>  DNA
<213>  Homosapiens

<400>  9526
taccagtctg tacaaaataa tttcccaggt atcctctcct ttaatgtcag aacagcctgc     60

agagggcagt gctgtcattt gtaagtcttt tttttttttt ttaattgcaa aaaatacgtg    120

acataaaatt tatcgtaagt agcattgagt acattcacaa cgctgtgcag ccatcaccac    180

tgtccatctc gtgaatgttg tagaatttca agattgtgga gttggactga atgctgcaca    240

gttcaaacag ctgcttattt cggctgtgaa ggacctgttt ggggaggttg atgccgcctt    300

acctttggac atcctaacct atgaagagaa gaccttgtca gccatcttga gaatatgtag    360

cagtggtctt gtcaaattgt ggagctcttt gaccctgtta ggatcctata aaggcaaaaa    420

atgtgctttc cgggtgattc aggtttctcc atttcttctt gcattatctg gtaatagtag    480

ggaactagta ttggattgaa tgaatagtct tccattttgg aaacgttcat ccactctcat    540

atttattttt tggtgcctgc atgtttgaag actgaagcag gctaaaagct cttgatgaaa    600

tttgagggtg ctgaagatgt tcccactaat ttccagccat cacctttggt ggggtgggct    660

tcggaggaca gtctgtctga acctgccagt gctgaccctg cagcactttc agcatatgca    720

catcaaagtt ggagaccgcg ctgaacttag gagggccttc acacagactg atgtggctac    780

cttctcagaa ttaacagggg atgtcaatcc tttgcatttg aatgaagact ttgcaaaaca    840

caccaagttt ggaaatacaa ttgtacatgg agttttgatc aacggactta tctcagctct    900

cctaggaact aaaatgccag ggccaggctg tgtatttctt tcccaggaaa ttagctttcc    960

agccccttta tatattggag aagttgtttt agcttctgca gaagtgaaaa agctgaagcg   1020

gttcattgct attattgcag tgtcatgttc tgtaatagaa agtaaaaaga ctgttatgga   1080

aggctgggtt aaagttatgg ttccagaagc ttccaaatcc tgaaatagat gttttaaaga   1140

tgcaacctca aacaccaatg ctgttgttaa agagcctatg gggaattgct gctctttacc   1200

aaagaatggt tgataggccc agaagcccat cttagttagg ggaagggagc aggaagaggg   1260

ttgttcaaat gcccactttc cagtttggcc ttatgcttca tgcagacttg agtgtatgca   1320

ggatttcatt atctgcctgg gttttttgtt tgttttttgt tttttaattc aagaagtagg   1380

ctgggcccgg tggctcatgc ctgtaatcct ggcactttgg gaggctgcgg caggcggatc   1440

acttgaggtc aggagtccaa gaccagcctg gccaacatgg tgaaacccca tctctaccaa   1500

aaaaaaaaaa aaaaaaaaag tgcaactagc tgtgcttggt gacttggccc tgtagtccca   1560

gttgcttggg aggctgaggt gggagaattg cttgggcctg agagctggag gttatggtga   1620

gaaactgaga ttgcaccact gcactgtagc ctgagtgaca gagcgagacc ctgtctcaag   1680

aaagaagtat tgggaaggtt atttaaagac tctactttta aatcaggcgt ggcagctcac   1740

gcctgtaatc ccagcatttt gggaggctga ggcaggcgaa tcacttgagg tcaggagttc   1800

aagaccagcc tggccaacat gtgaaacccc atctctacta aaaatacaaa aactaaccgg   1860

gcatggtggc gggcacctgt aatcccagct acttgggagg ctgaggcagg agaatctctt   1920

gaacctggga ggttgcagtg agctgaaatc acaccactgc acttcagcct gggtgacaga   1980

gcaaaactcc acctcaaaaa aaaaaaaaag attctacttt tagaaattca gacctagata   2040

gatttgcatt tggataacaa atccctacct atagccatgt ggaagcagct tgtcactgta   2100

ttttaactgt gtaacaatta ttgaaggcga aaatagaagt tgggtcatct ttgaacacct   2160

accttttatc aatgaatatt tttagactgt tcttcagtat ctgagtcaga gtttattgta   2220

atttgttatt tacaccaagg tggcatctta gtctaccttc agtgagactt gcgtttcagg   2280

ggaggggcgt atgtgcatcc tcggtctcag ttatgtaaac ggtctgatct gtaaaatagt   2340

ggtagcacat gccatgtggg atagttggtg gagatgatag atggagttaa gcacagggcc   2400

cagcctgtca gcagtagcta ctattattgt tgcccatttc ccctgcaact gaggtgagag   2460

gttttcctga gtttgaagct gactggccca cagttaaacg taacagacca gtttttcagg   2520

gtgtcagcca acctctatta gtgttcttaa gtacagtttc tgttataaaa gttcagatta   2580

ttccttgaaa atttggatct acctcccatt attatgagta atacatgctt atagtaaaaa   2640

aaaaaaaatt gtaagaaata aatattaaga agattatgga ggccaaattc ttaagacttt   2700

gggggctggg gtcagggagg ttatattgaa ggggagatgt gcctaacatg ttactactaa   2760

atggccatcc caacacagcc aacacttttg tttcccattt ttttttgttt cccgtttttt   2820

aataaaattg agatataatt cacataccat aaaattcacc ttttaaaagt gtacagttta   2880

gtggttttca gaatatccac aaagttgtac aaccatcacc aaatcaattt tttatagcat   2940

ttttcatcac ccccaaaaga acctcccatt agcagtcaat ccatttctct cctccagtct   3000

ttgggaatca ccagtctact ttctgtctct atgggtttcc ctgttctgga catttcataa   3060

aagttcatac aatgtatgat cctttggaac tggcttcttt gatatagcat gttttcaggg   3120

ttcatccatg ttacagcatg tatcagtaca tcattttatt ttatggctga ataatattcc   3180

attgtattta cccat                                                    3195


<210>  9527
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  9527

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp Val Lys Val 
145                 150                 155                 160 


Met Val Pro Glu Ala Ser Lys Ser 
                165             


<210>  9528
<211>  1242
<212>  DNA
<213>  Homosapiens

<400>  9528
gctggatgtg gtggcacgtg cctatactcc cagctactca ggagtctgag gcaggaggat     60

cacctgagcc tcgagagcca gaggtggagg ctgcagtgaa ctctgattgt accactgcac    120

ttcagcctag gtgacagggt gagaccctgc cttaaaacaa acaaacaaaa aaaacccaaa    180

taggccaaat tctcatcaaa actctgaaaa atagcatgtg cattggtcat ttctagccct    240

cttgacttac tgtaggtgtg atcagcactg gaaaagatgc ctgcccctgc tgccacatat    300

gaaagagtag tttacaaaaa cccttccgag taccactaca tgaaagtctg cctagaattt    360

caagattgtg gagttggact gaatgctgca cagttcaaac agctgcttat ttcggctgtg    420

aaggacctgt ttggggaggt tgatgccgcc ttacctttgg acatcctaac ctatgaagag    480

aagaccttgt cagccatctt gagaatatgt agcagtggtc ttgtcaaatt gtggagctct    540

ttgaccctgt taggatccta taaaggcaaa aaatgtgctt tccgggtgat tcaggtttct    600

ccatttcttc ttgcattatc tggtaatagt agggaactag tattggattg aatgaatagt    660

cttccatttt ggaaacgttc atccactctc atatttattt tttggtgcct gcatgtttga    720

agactgaagc aggctaaaag ctcttgatga aatttgaggg tgctgaagat gttcccacta    780

atttccagcc atcacctttg gtggggtggg cttcggagga cagtctgtct gaacctgcca    840

gtgctgaccc tgcagcactt tcagcatatg cacatcaaag ttggagaccg cgctgaactt    900

aggagggcct tcacacagac tgatgtggct accttctcag aattaacagg ggatgtcaat    960

cctttgcatt tgaatgaaga ctttgcaaaa cacaccaagt ttggaaatac aattgtacat   1020

ggagttttga tcaacggact tatctcagct ctcctaggaa ctaaaatgcc agggccaggc   1080

tgtgtatttc tttcccagga aattagcttt ccagcccctt tatatattgg agaagttgtt   1140

ttagcttctg cagaagtgaa aaagctgaag cggttcattg ctattattgc agtgtcatgt   1200

tctgtaatag aaagtaaaaa gactgttatg gaaggctggg tt                      1242


<210>  9529
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  9529

Met Pro Ala Pro Ala Ala Thr Tyr Glu Arg Val Val Tyr Lys Asn Pro 
1               5                   10                  15      


Ser Glu Tyr His Tyr Met Lys Val Cys Leu Glu Phe Gln Asp Cys Gly 
            20                  25                  30          


Val Gly Leu Asn Ala Ala Gln Phe Lys Gln Leu Leu Ile Ser Ala Val 
        35                  40                  45              


Lys Asp Leu Phe Gly Glu Val Asp Ala Ala Leu Pro Leu Asp Ile Leu 
    50                  55                  60                  


Thr Tyr Glu Glu Lys Thr Leu Ser Ala Ile Leu Arg Ile Cys Ser Ser 
65                  70                  75                  80  


Gly Leu Val Lys Leu Trp Ser Ser Leu Thr Leu Leu Gly Ser Tyr Lys 
                85                  90                  95      


Gly Lys Lys Cys Ala Phe Arg Val Ile Gln Val Ser Pro Phe Leu Leu 
            100                 105                 110         


Ala Leu Ser Gly Asn Ser Arg Glu Leu Val Leu Asp 
        115                 120                 


<210>  9530
<211>  2827
<212>  DNA
<213>  Homosapiens

<400>  9530
gctggatgtg gtggcacgtg cctatactcc cagctactca ggagtctgag gcaggaggat     60

cacctgagcc tcgagagcca gaggtggagg ctgcagtgaa ctctgattgt accactgcac    120

ttcagcctag gtgacagggt gagaccctgc cttaaaacaa acaaacaaaa aaaacccaaa    180

taggccaaat tctcatcaaa actctgaaaa atagcatgtg cattggtcat ttctagccct    240

cttgacttac tgtaggtgtg atcagcactg gaaaagatgc ctgcccctgc tgccacatat    300

gaaagagtag tttacaaaaa cccttccgag taccactaca tgaaagtctg cctagaattt    360

caagattgtg gagttggact gaatgctgca cagttcaaac agctgcttat ttcggctgtg    420

aaggacctgt ttggggaggt tgatgccgcc ttacctttgg acatcctaac ctatgaagag    480

aagaccttgt cagccatctt gagaatatgt agcagtggtc ttgtcaaatt gtggagctct    540

ttgaccctgt taggatccta taaaggcaaa aaatgtgctt tccgggtgat tcaggtttct    600

ccatttcttc ttgcattatc tggtaatagt agggaactag tattggattg aatgaatagt    660

cttccatttt ggaaacgttc atccactctc atatttattt tttggtgcct gcatgtttga    720

agactgaagc aggctaaaag ctcttgatga aatttgaggg tgctgaagat gttcccacta    780

atttccagcc atcacctttg gtggggtggg cttcggagga cagtctgtct gaacctgcca    840

gtgctgaccc tgcagcactt tcagcatatg cacatcaaag ttggagaccg cgctgaactt    900

aggagggcct tcacacagac tgatgtggct accttctcag aattaacagg ggatgtcaat    960

cctttgcatt tgaatgaaga ctttgcaaaa cacaccaagt ttggaaatac aattgtacat   1020

ggagttttga tcaacggact tatctcagct ctcctaggaa ctaaaatgcc agggccaggc   1080

tgtgtatttc tttcccagga aattagcttt ccagcccctt tatatattgg agaagttgtt   1140

ttagcttctg cagaagtgaa aaagctgaag cggttcattg ctattattgc agtgtcatgt   1200

tctgtaatag aaagtaaaaa gactgttatg gaaggctggg ttaaagttat ggttccagaa   1260

gcttccaaat cctgaaatag atgttttaaa gatgcaacct caaacaccaa tgctgttgtt   1320

aaagagccta tggggaattg ctgctcttta ccaaagaatg gttgataggc ccagaagccc   1380

atcttagtta ggggaaggga gcaggaagag ggttgttcaa atgcccactt tccagtttgg   1440

ccttatgctt catgcagact tgagtgtatg caggatttca ttatctgcct gggttttttg   1500

tttgtttttt gttttttaat tcaagaagta ggctgggccc ggtggctcat gcctgtaatc   1560

ctggcacttt gggaggctgc ggcaggcgga tcacttgagg tcaggagtcc aagaccagcc   1620

tggccaacat ggtgaaaccc catctctacc aaaaaaaaaa aaaaaaaaaa agtgcaacta   1680

gctgtgcttg gtgacttggc cctgtagtcc cagttgcttg ggaggctgag gtgggagaat   1740

tgcttgggcc tgagagctgg aggttatggt gagaaactga gattgcacca ctgcactgta   1800

gcctgagtga cagagcgaga ccctgtctca agaaagaagt attgggaagg ttatttaaag   1860

actctacttt taaatcaggc gtggcagctc acgcctgtaa tcccagcatt ttgggaggct   1920

gaggcaggcg aatcacttga ggtcaggagt tcaagaccag cctggccaac atgtgaaacc   1980

ccatctctac taaaaataca aaaactaacc gggcatggtg gcgggcacct gtaatcccag   2040

ctacttggga ggctgaggca ggagaatctc ttgaacctgg gaggttgcag tgagctgaaa   2100

tcacaccact gcacttcagc ctgggtgaca gagcaaaact ccacctcaaa aaaaaaaaaa   2160

agattctact tttagaaatt cagacctaga tagatttgca tttggataac aaatccctac   2220

ctatagccat gtggaagcag cttgtcactg tattttaact gtgtaacaat tattgaaggc   2280

gaaaatagaa gttgggtcat ctttgaacac ctacctttta tcaatgaata tttttagact   2340

gttcttcagt atctgagtca gagtttattg taatttgtta tttacaccaa ggtggcatct   2400

tagtctacct tcagtgagac ttgcgtttca ggggaggggc gtatgtgcat cctcggtctc   2460

agttatgtaa acggtctgat ctgtaaaata gtggtagcac atgccatgtg ggatagttgg   2520

tggagatgat agatggagtt aagcacaggg cccagcctgt cagcagtagc tactattatt   2580

gttgcccatt tcccctgcaa ctgaggtgag aggttttcct gagtttgaag ctgactggcc   2640

cacagttaaa cgtaacagac cagtttttca gggtgtcagc caacctctat tagtgttctt   2700

aagtacagtt tctgttataa aagttcagat tattccttga aaatttggat ctacctccca   2760

ttattatgag taatacatgc ttatagtaaa aaaaaaaaaa ttgtaagaaa taaatattaa   2820

gaagatt                                                             2827


<210>  9531
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  9531

Met Pro Ala Pro Ala Ala Thr Tyr Glu Arg Val Val Tyr Lys Asn Pro 
1               5                   10                  15      


Ser Glu Tyr His Tyr Met Lys Val Cys Leu Glu Phe Gln Asp Cys Gly 
            20                  25                  30          


Val Gly Leu Asn Ala Ala Gln Phe Lys Gln Leu Leu Ile Ser Ala Val 
        35                  40                  45              


Lys Asp Leu Phe Gly Glu Val Asp Ala Ala Leu Pro Leu Asp Ile Leu 
    50                  55                  60                  


Thr Tyr Glu Glu Lys Thr Leu Ser Ala Ile Leu Arg Ile Cys Ser Ser 
65                  70                  75                  80  


Gly Leu Val Lys Leu Trp Ser Ser Leu Thr Leu Leu Gly Ser Tyr Lys 
                85                  90                  95      


Gly Lys Lys Cys Ala Phe Arg Val Ile Gln Val Ser Pro Phe Leu Leu 
            100                 105                 110         


Ala Leu Ser Gly Asn Ser Arg Glu Leu Val Leu Asp 
        115                 120                 


<210>  9532
<211>  3347
<212>  DNA
<213>  Homosapiens

<400>  9532
gctggatgtg gtggcacgtg cctatactcc cagctactca ggagtctgag gcaggaggat     60

cacctgagcc tcgagagcca gaggtggagg ctgcagtgaa ctctgattgt accactgcac    120

ttcagcctag gtgacagggt gagaccctgc cttaaaacaa acaaacaaaa aaaacccaaa    180

taggccaaat tctcatcaaa actctgaaaa atagcatgtg cattggtcat ttctagccct    240

cttgacttac tgtaggtgtg atcagcactg gaaaagatgc ctgcccctgc tgccacatat    300

gaaagagtag tttacaaaaa cccttccgag taccactaca tgaaagtctg cctagaattt    360

caagattgtg gagttggact gaatgctgca cagttcaaac agctgcttat ttcggctgtg    420

aaggacctgt ttggggaggt tgatgccgcc ttacctttgg acatcctaac ctatgaagag    480

aagaccttgt cagccatctt gagaatatgt agcagtggtc ttgtcaaatt gtggagctct    540

ttgaccctgt taggatccta taaaggcaaa aaatgtgctt tccgggtgat tcaggtttct    600

ccatttcttc ttgcattatc tggtaatagt agggaactag tattggattg aatgaatagt    660

cttccatttt ggaaacgttc atccactctc atatttattt tttggtgcct gcatgtttga    720

agactgaagc aggctaaaag ctcttgatga aatttgaggg tgctgaagat gttcccacta    780

atttccagcc atcacctttg gtggggtggg cttcggagga cagtctgtct gaacctgcca    840

gtgctgaccc tgcagcactt tcagcatatg cacatcaaag ttggagaccg cgctgaactt    900

aggagggcct tcacacagac tgatgtggct accttctcag aattaacagg ggatgtcaat    960

cctttgcatt tgaatgaaga ctttgcaaaa cacaccaagt ttggaaatac aattgtacat   1020

ggagttttga tcaacggact tatctcagct ctcctaggaa ctaaaatgcc agggccaggc   1080

tgtgtatttc tttcccagga aattagcttt ccagcccctt tatatattgg agaagttgtt   1140

ttagcttctg cagaagtgaa aaagctgaag cggttcattg ctattattgc agtgtcatgt   1200

tctgtaatag aaagtaaaaa gactgttatg gaaggctggg ttaaagttat ggttccagaa   1260

gcttccaaat cctgaaatag atgttttaaa gatgcaacct caaacaccaa tgctgttgtt   1320

aaagagccta tggggaattg ctgctcttta ccaaagaatg gttgataggc ccagaagccc   1380

atcttagtta ggggaaggga gcaggaagag ggttgttcaa atgcccactt tccagtttgg   1440

ccttatgctt catgcagact tgagtgtatg caggatttca ttatctgcct gggttttttg   1500

tttgtttttt gttttttaat tcaagaagta ggctgggccc ggtggctcat gcctgtaatc   1560

ctggcacttt gggaggctgc ggcaggcgga tcacttgagg tcaggagtcc aagaccagcc   1620

tggccaacat ggtgaaaccc catctctacc aaaaaaaaaa aaaaaaaaaa agtgcaacta   1680

gctgtgcttg gtgacttggc cctgtagtcc cagttgcttg ggaggctgag gtgggagaat   1740

tgcttgggcc tgagagctgg aggttatggt gagaaactga gattgcacca ctgcactgta   1800

gcctgagtga cagagcgaga ccctgtctca agaaagaagt attgggaagg ttatttaaag   1860

actctacttt taaatcaggc gtggcagctc acgcctgtaa tcccagcatt ttgggaggct   1920

gaggcaggcg aatcacttga ggtcaggagt tcaagaccag cctggccaac atgtgaaacc   1980

ccatctctac taaaaataca aaaactaacc gggcatggtg gcgggcacct gtaatcccag   2040

ctacttggga ggctgaggca ggagaatctc ttgaacctgg gaggttgcag tgagctgaaa   2100

tcacaccact gcacttcagc ctgggtgaca gagcaaaact ccacctcaaa aaaaaaaaaa   2160

agattctact tttagaaatt cagacctaga tagatttgca tttggataac aaatccctac   2220

ctatagccat gtggaagcag cttgtcactg tattttaact gtgtaacaat tattgaaggc   2280

gaaaatagaa gttgggtcat ctttgaacac ctacctttta tcaatgaata tttttagact   2340

gttcttcagt atctgagtca gagtttattg taatttgtta tttacaccaa ggtggcatct   2400

tagtctacct tcagtgagac ttgcgtttca ggggaggggc gtatgtgcat cctcggtctc   2460

agttatgtaa acggtctgat ctgtaaaata gtggtagcac atgccatgtg ggatagttgg   2520

tggagatgat agatggagtt aagcacaggg cccagcctgt cagcagtagc tactattatt   2580

gttgcccatt tcccctgcaa ctgaggtgag aggttttcct gagtttgaag ctgactggcc   2640

cacagttaaa cgtaacagac cagtttttca gggtgtcagc caacctctat tagtgttctt   2700

aagtacagtt tctgttataa aagttcagat tattccttga aaatttggat ctacctccca   2760

ttattatgag taatacatgc ttatagtaaa aaaaaaaaaa ttgtaagaaa taaatattaa   2820

gaagattatg gaggccaaat tcttaagact ttgggggctg gggtcaggga ggttatattg   2880

aaggggagat gtgcctaaca tgttactact aaatggccat cccaacacag ccaacacttt   2940

tgtttcccat ttttttttgt ttcccgtttt ttaataaaat tgagatataa ttcacatacc   3000

ataaaattca ccttttaaaa gtgtacagtt tagtggtttt cagaatatcc acaaagttgt   3060

acaaccatca ccaaatcaat tttttatagc atttttcatc acccccaaaa gaacctccca   3120

ttagcagtca atccatttct ctcctccagt ctttgggaat caccagtcta ctttctgtct   3180

ctatgggttt ccctgttctg gacatttcat aaaagttcat acaatgtatg atcctttgga   3240

actggcttct ttgatatagc atgttttcag ggttcatcca tgttacagca tgtatcagta   3300

catcatttta ttttatggct gaataatatt ccattgtatt tacccat                 3347


<210>  9533
<211>  124
<212>  PRT
<213>  Homosapiens

<400>  9533

Met Pro Ala Pro Ala Ala Thr Tyr Glu Arg Val Val Tyr Lys Asn Pro 
1               5                   10                  15      


Ser Glu Tyr His Tyr Met Lys Val Cys Leu Glu Phe Gln Asp Cys Gly 
            20                  25                  30          


Val Gly Leu Asn Ala Ala Gln Phe Lys Gln Leu Leu Ile Ser Ala Val 
        35                  40                  45              


Lys Asp Leu Phe Gly Glu Val Asp Ala Ala Leu Pro Leu Asp Ile Leu 
    50                  55                  60                  


Thr Tyr Glu Glu Lys Thr Leu Ser Ala Ile Leu Arg Ile Cys Ser Ser 
65                  70                  75                  80  


Gly Leu Val Lys Leu Trp Ser Ser Leu Thr Leu Leu Gly Ser Tyr Lys 
                85                  90                  95      


Gly Lys Lys Cys Ala Phe Arg Val Ile Gln Val Ser Pro Phe Leu Leu 
            100                 105                 110         


Ala Leu Ser Gly Asn Ser Arg Glu Leu Val Leu Asp 
        115                 120                 


<210>  9534
<211>  1061
<212>  DNA
<213>  Homosapiens

<400>  9534
aggtttctcc atttcttctt gcattatctg gtaatagtag ggaactagta ttggattgaa     60

tgaatagtct tccattttgg aaacgttcat ccactctcat atttattttt tggtgcctgc    120

atgtttgaag actgaagcag gctaaaagct cttgatgaaa tttgagggtg ctgaagatgt    180

tcccactaat ttccagccat cacctttggt ggggtgggct tcggaggaca gtctgtctga    240

acctgccagt gctgaccctg cagcactttc agcatatgca catcaaagtt ggagaccgcg    300

ctgaacttag gagggccttc acacagactg atgtggctac cttctcagaa ttaacagggg    360

atgtcaatcc tttgcatttg aatgaagact ttgcaaaaca caccaagttt ggaaatacaa    420

ttgtacatgg agttttgatc aacggactta tctcagctct cctaggaact aaaatgccag    480

ggccaggctg tgtatttctt tcccaggaaa ttagctttcc agccccttta tatattggag    540

aagttgtttt agcttctgca gaagtgaaaa agctgaagcg gttcattgct attattgcag    600

tgtcatgttc tgtaatagaa agtaaaaaga ctgttatgga aggctgggtt aaagttatgg    660

ttccagaagc ttccaaatcc tgaaatagat gttttaaaga tgcaacctca aacaccaatg    720

ctgttgttaa agagcctatg gggaattgct gctctttacc aaagaatggt tgataggccc    780

agaagcccat cttagttagg ggaagggagc aggaagaggg ttgttcaaat gcccactttc    840

cagtttggcc ttatgcttca tgcagacttg agtgtatgca ggatttcatt atctgctggg    900

attacaggtg tgagcctctg tactcagccc atattttgat atattttctt ctggtgtttg    960

tcctgtagat atgttgggat tatacggatg ctaaattgct tttttcattt actattatat   1020

caagagcatt tctcaagatc ataaaatatt ttttaatcat g                       1061


<210>  9535
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  9535

Met Pro Thr Phe Gln Phe Gly Leu Met Leu His Ala Asp Leu Ser Val 
1               5                   10                  15      


Cys Arg Ile Ser Leu Ser Ala Gly Ile Thr Gly Val Ser Leu Cys Thr 
            20                  25                  30          


Gln Pro Ile Phe 
        35      


<210>  9536
<211>  2112
<212>  DNA
<213>  Homosapiens

<400>  9536
tctggtaata gtagggaact agtattggat tgaatgaata gtcttccatt ttggaaacgt     60

tcatccactc tcatatttat tttttggtgc ctgcatgttt gaagactgaa gcaggctaaa    120

agctcttgat gaaatttgag ggtgctgaag atgttcccac taatttccag ccatcacctt    180

tggtggggtg ggcttcggag gacagtctgt ctgaacctgc cagtgctgac cctgcagcac    240

tttcagcata tgcacatcaa agttggagac cgcgctgaac ttaggagggc cttcacacag    300

actgatgtgg ctaccttctc agaattaaca ggggatgtca atcctttgca tttgaatgaa    360

gactttgcaa aacacaccaa gtttggaaat acaattgtac atggagtttt gatcaacgga    420

cttatctcag ctctcctagg aactaaaatg ccagggccag gctgtgtatt tctttcccag    480

gaaattagct ttccagcccc tttatatatt ggagaagttg ttttagcttc tgcagaagtg    540

aaaaagctga agcggttcat tgctattatt gcagtgtcat gttctgtaat agaaagtaaa    600

aagactgtta tggaaggctg ggttaaagtt atggttccag aagcttccaa atcctgaaat    660

agatgtttta aagatgcaac ctcaaacacc aatgctgttg ttaaagagcc tatggggaat    720

tgctgctctt taccaaagaa tggttgatag gcccagaagc ccatcttagt taggggaagg    780

gagcaggaag agggttgttc aaatgcccac tttccagttt ggcccggtgg ctcatgcctg    840

taatcctggc actttgggag gctgcggcag gcggatcact tgaggtcagg agtccaagac    900

cagcctggcc aacatggtga aaccccatct ctaccaaaaa aaaaaaaaaa aaaaaagtgc    960

aactagctgt gcttggtgac ttggccctgt agtcccagtt gcttgggagg ctgaggtggg   1020

agaattgctt gggcctgaga gctggaggtt atggtgagaa actgagattg caccactgca   1080

ctgtagcctg agtgacagag cgagaccctg tctcaagaaa gaagtattgg gaaggttatt   1140

taaagactct acttttaaat caggcgtggc agctcacgcc tgtaatccca gcattttggg   1200

aggctgaggc aggcgaatca cttgaggtca ggagttcaag accagcctgg ccaacatgtg   1260

aaaccccatc tctactaaaa atacaaaaac taaccgggca tggtggcggg cacctgtaat   1320

cccagctact tgggaggctg aggcaggaga atctcttgaa cctgggaggt tgcagtgagc   1380

tgaaatcaca ccactgcact tcagcctggg tgacagagca aaactccacc tcaaaaaaaa   1440

aaaaaagatt ctacttttag aaattcagac ctagatagat ttgcatttgg ataacaaatc   1500

cctacctata gccatgtgga agcagcttgt cactgtattt taactgtgta acaattattg   1560

aaggcgaaaa tagaagttgg gtcatctttg aacacctacc ttttatcaat gaatattttt   1620

agactgttct tcagtatctg agtcagagtt tattgtaatt tgttatttac accaaggtgg   1680

catcttagtc taccttcagt gagacttgcg tttcagggga ggggcgtatg tgcatcctcg   1740

gtctcagtta tgtaaacggt ctgatctgta aaatagtggt agcacatgcc atgtgggata   1800

gttggtggag atgatagatg gagttaagca cagggcccag cctgtcagca gtagctacta   1860

ttattgttgc ccatttcccc tgcaactgag gtgagaggtt ttcctgagtt tgaagctgac   1920

tggcccacag ttaaacgtaa cagaccagtt tttcagggtg tcagccaacc tctattagtg   1980

ttcttaagta cagtttctgt tataaaagtt cagattattc cttgaaaatt tggatctacc   2040

tcccattatt atgagtaata catgcttata gtaaaaaaaa aaaaattgta agaaataaat   2100

attaagaaga tt                                                       2112


<210>  9537
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  9537

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp Val Lys Val 
145                 150                 155                 160 


Met Val Pro Glu Ala Ser Lys Ser 
                165             


<210>  9538
<211>  2632
<212>  DNA
<213>  Homosapiens

<400>  9538
tctggtaata gtagggaact agtattggat tgaatgaata gtcttccatt ttggaaacgt     60

tcatccactc tcatatttat tttttggtgc ctgcatgttt gaagactgaa gcaggctaaa    120

agctcttgat gaaatttgag ggtgctgaag atgttcccac taatttccag ccatcacctt    180

tggtggggtg ggcttcggag gacagtctgt ctgaacctgc cagtgctgac cctgcagcac    240

tttcagcata tgcacatcaa agttggagac cgcgctgaac ttaggagggc cttcacacag    300

actgatgtgg ctaccttctc agaattaaca ggggatgtca atcctttgca tttgaatgaa    360

gactttgcaa aacacaccaa gtttggaaat acaattgtac atggagtttt gatcaacgga    420

cttatctcag ctctcctagg aactaaaatg ccagggccag gctgtgtatt tctttcccag    480

gaaattagct ttccagcccc tttatatatt ggagaagttg ttttagcttc tgcagaagtg    540

aaaaagctga agcggttcat tgctattatt gcagtgtcat gttctgtaat agaaagtaaa    600

aagactgtta tggaaggctg ggttaaagtt atggttccag aagcttccaa atcctgaaat    660

agatgtttta aagatgcaac ctcaaacacc aatgctgttg ttaaagagcc tatggggaat    720

tgctgctctt taccaaagaa tggttgatag gcccagaagc ccatcttagt taggggaagg    780

gagcaggaag agggttgttc aaatgcccac tttccagttt ggcccggtgg ctcatgcctg    840

taatcctggc actttgggag gctgcggcag gcggatcact tgaggtcagg agtccaagac    900

cagcctggcc aacatggtga aaccccatct ctaccaaaaa aaaaaaaaaa aaaaaagtgc    960

aactagctgt gcttggtgac ttggccctgt agtcccagtt gcttgggagg ctgaggtggg   1020

agaattgctt gggcctgaga gctggaggtt atggtgagaa actgagattg caccactgca   1080

ctgtagcctg agtgacagag cgagaccctg tctcaagaaa gaagtattgg gaaggttatt   1140

taaagactct acttttaaat caggcgtggc agctcacgcc tgtaatccca gcattttggg   1200

aggctgaggc aggcgaatca cttgaggtca ggagttcaag accagcctgg ccaacatgtg   1260

aaaccccatc tctactaaaa atacaaaaac taaccgggca tggtggcggg cacctgtaat   1320

cccagctact tgggaggctg aggcaggaga atctcttgaa cctgggaggt tgcagtgagc   1380

tgaaatcaca ccactgcact tcagcctggg tgacagagca aaactccacc tcaaaaaaaa   1440

aaaaaagatt ctacttttag aaattcagac ctagatagat ttgcatttgg ataacaaatc   1500

cctacctata gccatgtgga agcagcttgt cactgtattt taactgtgta acaattattg   1560

aaggcgaaaa tagaagttgg gtcatctttg aacacctacc ttttatcaat gaatattttt   1620

agactgttct tcagtatctg agtcagagtt tattgtaatt tgttatttac accaaggtgg   1680

catcttagtc taccttcagt gagacttgcg tttcagggga ggggcgtatg tgcatcctcg   1740

gtctcagtta tgtaaacggt ctgatctgta aaatagtggt agcacatgcc atgtgggata   1800

gttggtggag atgatagatg gagttaagca cagggcccag cctgtcagca gtagctacta   1860

ttattgttgc ccatttcccc tgcaactgag gtgagaggtt ttcctgagtt tgaagctgac   1920

tggcccacag ttaaacgtaa cagaccagtt tttcagggtg tcagccaacc tctattagtg   1980

ttcttaagta cagtttctgt tataaaagtt cagattattc cttgaaaatt tggatctacc   2040

tcccattatt atgagtaata catgcttata gtaaaaaaaa aaaaattgta agaaataaat   2100

attaagaaga ttatggaggc caaattctta agactttggg ggctggggtc agggaggtta   2160

tattgaaggg gagatgtgcc taacatgtta ctactaaatg gccatcccaa cacagccaac   2220

acttttgttt cccatttttt tttgtttccc gttttttaat aaaattgaga tataattcac   2280

ataccataaa attcaccttt taaaagtgta cagtttagtg gttttcagaa tatccacaaa   2340

gttgtacaac catcaccaaa tcaatttttt atagcatttt tcatcacccc caaaagaacc   2400

tcccattagc agtcaatcca tttctctcct ccagtctttg ggaatcacca gtctactttc   2460

tgtctctatg ggtttccctg ttctggacat ttcataaaag ttcatacaat gtatgatcct   2520

ttggaactgg cttctttgat atagcatgtt ttcagggttc atccatgtta cagcatgtat   2580

cagtacatca ttttatttta tggctgaata atattccatt gtatttaccc at           2632


<210>  9539
<211>  168
<212>  PRT
<213>  Homosapiens

<400>  9539

Met Phe Pro Leu Ile Ser Ser His His Leu Trp Trp Gly Gly Leu Arg 
1               5                   10                  15      


Arg Thr Val Cys Leu Asn Leu Pro Val Leu Thr Leu Gln His Phe Gln 
            20                  25                  30          


His Met His Ile Lys Val Gly Asp Arg Ala Glu Leu Arg Arg Ala Phe 
        35                  40                  45              


Thr Gln Thr Asp Val Ala Thr Phe Ser Glu Leu Thr Gly Asp Val Asn 
    50                  55                  60                  


Pro Leu His Leu Asn Glu Asp Phe Ala Lys His Thr Lys Phe Gly Asn 
65                  70                  75                  80  


Thr Ile Val His Gly Val Leu Ile Asn Gly Leu Ile Ser Ala Leu Leu 
                85                  90                  95      


Gly Thr Lys Met Pro Gly Pro Gly Cys Val Phe Leu Ser Gln Glu Ile 
            100                 105                 110         


Ser Phe Pro Ala Pro Leu Tyr Ile Gly Glu Val Val Leu Ala Ser Ala 
        115                 120                 125             


Glu Val Lys Lys Leu Lys Arg Phe Ile Ala Ile Ile Ala Val Ser Cys 
    130                 135                 140                 


Ser Val Ile Glu Ser Lys Lys Thr Val Met Glu Gly Trp Val Lys Val 
145                 150                 155                 160 


Met Val Pro Glu Ala Ser Lys Ser 
                165             


<210>  9540
<211>  2580
<212>  DNA
<213>  Homosapiens

<400>  9540
ctgtctgaac ctgccagtgc tgaccctgca gcactttcag catatgcaca tcaaagttgg     60

agaccgcgct gaacttagga gggccttcac acagactgat gtggctacct tctcagaatt    120

aacaggggat gtcaatcctt tgcatttgaa tgaagacttt gcaaaacaca ccaagtttgg    180

aaatacaatt gtacatggag ttttgatcaa cggacttatc tcagctctcc taggaactaa    240

aatgccaggg ccaggctgtg tatttctttc ccaggaaatt agctttccag cccctttata    300

tattggagaa gttgttttag cttctgcaga agtgaaaaag ctgaagcggt tcattgctat    360

tattgcagtg tcatgttctg taatagaaag taaaaagact gttatggaag gctgggttaa    420

agttatggtt ccagaagctt ccaaatcctg aaatagatgt tttaaagatg caacctcaaa    480

caccaatgct gttgttaaag agcctatggg gaattgctgc tctttaccaa agaatggttg    540

ataggcccag aagcccatct tagttagggg aagggagcag gaagagggtt gttcaaatgc    600

ccactttcca gtttggcctt atgcttcatg cagacttgag tgtatgcagg atttcattat    660

ctgcctgggt tttttgtttg ttttttgttt tttaattcaa gaagtaggct gggcccggtg    720

gctcatgcct gtaatcctgg catgctggga ttacagatgt gagccaccat gtccagcatg    780

tttcagacct ttaaagtgtc agactaagtt aatcttcccg agatccagac aagggaaggc    840

ctggctgcat caagcagatt ctctgcaaat gcaagttttc tccaaaaaag acagctttgc    900

agggctgctt cttttggctc tctgaacagc catctgaaaa tatgacaaat atattttggg    960

gtgaaatatt tttatttccc tcattcgtgt tgctggaact ggagcactgt cagtttctat   1020

aatggcatct tacatggcat taaaataatt ggaatcattc tatagcaatc tttttgcttt   1080

cggaatgttc tagatcttat tccccgctag agttgtagcg ttttcctaat actattagtt   1140

gaaagtcttc cacccatgca tatcacctac acattttcta agccgacatt cagtgattat   1200

ttgtcttcac cgaagaatgg cttaaagggt taaagatgaa aaatataggg tacggaaggg   1260

atgtcagatc tgaatgatag ttgatttata ctgtgtaact ttcaaaagta gctactcaat   1320

gtgagcattt ccactgtttt tttttttgtt tgttttctga gacagagtct cactctgtct   1380

cccaggctgg agttgcagtg gtgcaatgac tgcagcacct cctgggctta cacaatcctg   1440

cctcagcctc ctatatagca gagaacagag gtgcacacca ccatatctgg cttatttttt   1500

gattttttgc agagatgagg tctcactttg ttgcccaggc tagtctcaaa ctcctgggct   1560

caagcaatcc tcccaccttg gcttcccaaa gtgctgggat tacaggcatg agccactgtg   1620

ctcagccttc atgttcactt ttttaaaatg tatgtatttt ttatagagat gtgggtctca   1680

ctgtgtcgcc caggttgtct cgaactcctg gtctcaagcg atactcctgc tttggcctcc   1740

caaaatgctg gaatgagcct ctgcatacag agttccacat ttttatgctc cctgagtcat   1800

ggtctttgaa atctataaat caataaaggt tggaaacaga gaagtagaca agaagttatc   1860

agtacttctc tttagtaact tgtcattttt atccagagtc aagattctca aaccacacgt   1920

gctttgttaa agctggctat aaggaaaact ggttgcttgg ctttttcatt gagtctatac   1980

aaactgctca aaagaatgac tcttaatgaa agcctgagtg accctcaaat taggaaattc   2040

tctcccagat aattgagaag tggccttgac tgtaccaggt cacacatgga aataagtaca   2100

aaagtaatga ctaaaatagg ccaagttgac cgagcacttt gtacataggg gtattatacg   2160

actgcaaatt gtgtgatgtt taattgtcac agaaagagat actcgtttta agcactttta   2220

gcctaatgta ctggaaaatt gcttaatgga tttttatact ctattggaaa catttccata   2280

ttggtgaaat gccactcatt cctttttctg aggagcaaat cttgagtagc aatgggaaga   2340

aagcctggca acagccacca tttgtcttgt ggacctgaca tgcttattca cctagaaaaa   2400

gaagaaattg ctaaatgcac actgatacct cttaggtaac cacaggtttt cattttgtgc   2460

tgaattatta gtcatttttc ctttatgttt ttagagtatg attcagagac caatttattc   2520

ccaaagaaaa ttgccattac atctactaag ttttcatatt aaaacatttt ctaccaaggg   2580


<210>  9541
<211>  93
<212>  PRT
<213>  Homosapiens

<400>  9541

Met Gln Asp Phe Ile Ile Cys Leu Gly Phe Leu Phe Val Phe Cys Phe 
1               5                   10                  15      


Leu Ile Gln Glu Val Gly Trp Ala Arg Trp Leu Met Pro Val Ile Leu 
            20                  25                  30          


Ala Cys Trp Asp Tyr Arg Cys Glu Pro Pro Cys Pro Ala Cys Phe Arg 
        35                  40                  45              


Pro Leu Lys Cys Gln Thr Lys Leu Ile Phe Pro Arg Ser Arg Gln Gly 
    50                  55                  60                  


Lys Ala Trp Leu His Gln Ala Asp Ser Leu Gln Met Gln Val Phe Ser 
65                  70                  75                  80  


Lys Lys Asp Ser Phe Ala Gly Leu Leu Leu Leu Ala Leu 
                85                  90              


<210>  9542
<211>  957
<212>  DNA
<213>  Homosapiens

<400>  9542
ctagctgtgc ttggtgactt ggccctgtag tcccagttgc ttgggaggct gaggcaggcg     60

aatcacttga ggtcaggagt tcaagaccag cctggccaac atgtgaaacc ccatctctac    120

taaaaataca aaaactaacc gggcatggtg gcgggcacct gtaatcccag ctacttggga    180

ggctgaggca ggagaatctc ttgaacctgg gaggttgcag tgagctgaaa tcacaccact    240

gcacttcagc ctgggtgaca gagcaaaact ccacctcaaa aaaaaaaaaa agattctact    300

tttagaaatt cagacctaga tagatttgca tttggataac aaatccctac ctatagccat    360

gtggaagcag cttgtcactg tattttaact gtgtaacaat tattgaaggc gaaaatagaa    420

gttgggtcat ctttgaacac ctacctttta tcaatgaata tttttagact gttcttcagt    480

atctgagtca gagtttattg taatttgtta tttacaccaa ggtggcatct tagtctacct    540

tcagtgagac ttgcgtttca ggggaggggc gtatgtgcat cctcggtctc agttatgtaa    600

acggtctgat ctgtaaaata gtggtagcac atgccatgtg ggatagttgg tggagatgat    660

agatggagtt aagcacaggg cccagcctgt cagcagtagc tactattatt gttgcccatt    720

tcccctgcaa ctgaggtgag aggttttcct gagtttgaag ctgactggcc cacagttaaa    780

cgtaacagac cagtttttca gggtgtcagc caacctctat tagtgttctt aagtacagtt    840

tctgttataa aagttcagat tattccttga aaatttggat ctacctccca ttattatgag    900

taatacatgc ttatagtaaa aaaaaaaaaa ttgtaagaaa taaatattaa gaagatt       957


<210>  9543
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  9543

Leu Gly Pro Val Val Pro Val Ala Trp Glu Ala Glu Ala Gly Glu Ser 
1               5                   10                  15      


Leu Glu Val Arg Ser Ser Arg Pro Ala Trp Pro Thr Cys Glu Thr Pro 
            20                  25                  30          


Ser Leu Leu Lys Ile Gln Lys Leu Thr Gly His Gly Gly Gly His Leu 
        35                  40                  45              


<210>  9544
<211>  1477
<212>  DNA
<213>  Homosapiens

<400>  9544
ctagctgtgc ttggtgactt ggccctgtag tcccagttgc ttgggaggct gaggcaggcg     60

aatcacttga ggtcaggagt tcaagaccag cctggccaac atgtgaaacc ccatctctac    120

taaaaataca aaaactaacc gggcatggtg gcgggcacct gtaatcccag ctacttggga    180

ggctgaggca ggagaatctc ttgaacctgg gaggttgcag tgagctgaaa tcacaccact    240

gcacttcagc ctgggtgaca gagcaaaact ccacctcaaa aaaaaaaaaa agattctact    300

tttagaaatt cagacctaga tagatttgca tttggataac aaatccctac ctatagccat    360

gtggaagcag cttgtcactg tattttaact gtgtaacaat tattgaaggc gaaaatagaa    420

gttgggtcat ctttgaacac ctacctttta tcaatgaata tttttagact gttcttcagt    480

atctgagtca gagtttattg taatttgtta tttacaccaa ggtggcatct tagtctacct    540

tcagtgagac ttgcgtttca ggggaggggc gtatgtgcat cctcggtctc agttatgtaa    600

acggtctgat ctgtaaaata gtggtagcac atgccatgtg ggatagttgg tggagatgat    660

agatggagtt aagcacaggg cccagcctgt cagcagtagc tactattatt gttgcccatt    720

tcccctgcaa ctgaggtgag aggttttcct gagtttgaag ctgactggcc cacagttaaa    780

cgtaacagac cagtttttca gggtgtcagc caacctctat tagtgttctt aagtacagtt    840

tctgttataa aagttcagat tattccttga aaatttggat ctacctccca ttattatgag    900

taatacatgc ttatagtaaa aaaaaaaaaa ttgtaagaaa taaatattaa gaagattatg    960

gaggccaaat tcttaagact ttgggggctg gggtcaggga ggttatattg aaggggagat   1020

gtgcctaaca tgttactact aaatggccat cccaacacag ccaacacttt tgtttcccat   1080

ttttttttgt ttcccgtttt ttaataaaat tgagatataa ttcacatacc ataaaattca   1140

ccttttaaaa gtgtacagtt tagtggtttt cagaatatcc acaaagttgt acaaccatca   1200

ccaaatcaat tttttatagc atttttcatc acccccaaaa gaacctccca ttagcagtca   1260

atccatttct ctcctccagt ctttgggaat caccagtcta ctttctgtct ctatgggttt   1320

ccctgttctg gacatttcat aaaagttcat acaatgtatg atcctttgga actggcttct   1380

ttgatatagc atgttttcag ggttcatcca tgttacagca tgtatcagta catcatttta   1440

ttttatggct gaataatatt ccattgtatt tacccat                            1477


<210>  9545
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  9545

Leu Gly Pro Val Val Pro Val Ala Trp Glu Ala Glu Ala Gly Glu Ser 
1               5                   10                  15      


Leu Glu Val Arg Ser Ser Arg Pro Ala Trp Pro Thr Cys Glu Thr Pro 
            20                  25                  30          


Ser Leu Leu Lys Ile Gln Lys Leu Thr Gly His Gly Gly Gly His Leu 
        35                  40                  45              


<210>  9546
<211>  2922
<212>  DNA
<213>  Homosapiens

<400>  9546
gtgttgacag cggcggcggt ggaaccgggc gggcggcggg agtcggcgcc tcgggttcct     60

acctcgcgtc cctaggcggc ggcggccggg cgtcccggga tggccttcat ggagaagccg    120

ccagccggca aggtgctgct ggacgacacg gtgccgctga cagcagccat cgaggcgagc    180

cagagcctgc agtcccacac ggaatatatt attcgagtgc aaagaggaat ttctgtggaa    240

aacagctggc agattgttag aagatacagt gactttgatt tgcttaacaa cagcttacag    300

attgcaggcc taagtctacc tcttcctccc aaaaaattga ttggtaacat ggatcgtgaa    360

ttcatagctg aaaggcagaa aggtcttcag aactatctca acgtgatcac aacaaatcat    420

atcttgtcta attgtgagct ggttaagaag tttttagatc caaacaacta ttccgcaaac    480

tatactgaga ttgccttgca acaggtttcc atgttcttcc gatcagaacc aaagtgggag    540

gtggtggaac ctttgaaaga cataggttgg agaataagga agaaatattt cttgatgaag    600

attaaaaatc agccaaagga acggctagtg ttaagctggg ctgaccttgg cccagacaag    660

tatttgtcag ataaagattt tcagtgtcta atcaaacttc tgccttcttg tttgcaccct    720

tacatctatc gggttacctt tgccacagct aatgaatcct cagcgttgct aattaggatg    780

tttaacgaaa agggaacatt gaaggatctg atctacaagg caaaaccaaa agacccattt    840

ctaaagaagt actgcaaccc taagaagatt cagggcctgg aactccagca aataaaaaca    900

tatggacggc aaatattaga ggtactgaag tttcttcatg acaagggatt cccttatggg    960

catcttcacg cctccaatgt gatgctcgat ggggacactt gccggctgct ggaccttgag   1020

aattccttat tgggcctgcc ttccttctac cgatcttatt tttcacaatt caggaaaatc   1080

aatacattgg aaagtgtgga tgtccactgc tttggccact tactgtatga aatgacttat   1140

ggacgaccgc cagactcggt gcctgtggac tccttccctc ctgccccgtc catggctgtg   1200

gtggccgtgt tggagtctac gctgtcttgt gaagcctgta aaaatggcat gcctaccatc   1260

tcccggctct tacagatgcc attattcagc gatgttttac taaccacttc tgaaaaacca   1320

cagtttaaga tccctacaaa gttaaaagag gcattgagaa ttgccaaaga atgtatagag   1380

aagagactaa ttgaggaaca gaaacagatt caccagcatc gaagactgac aagagctcag   1440

tcccaccatg gatctgagga ggaaagaaaa aaaagaaaga ttttagctcg aaagaagtca   1500

aaacgatctg ctcttgaaaa tagtgaagag cattcagcga agtacagcaa ctccaataat   1560

tcagcaggat ctggggccag ctcacctctc acgtccccgt catcgccaac tccaccctct   1620

acatcaggga tatctgcatt acctccacct cctccacctc caccaccacc agcagctccc   1680

ttgcctcctg cgagcaccga ggcacctgcc cagctctcgt ctcaggctgt gaatggcatg   1740

agccgagggg ccttgctcag ctccatccag aatttccaaa aaggaacttt gaggaaagcc   1800

aaaacctgtg atcacagtgc tccgaagatc ggctgaagct tcctgtttac acttggaggg   1860

aaaagttctt ttttattcct actcacccct accccccaaa ctaccctctt cctgggaaag   1920

taattgctga gccagtacag ccacaaacag tactattttg cagatgctca tgtaagcagc   1980

ttttcgagag aaataattct ttaagcagaa taaagttagg ctggcattgc tcccttaaga   2040

tcttgctcct ttattaaccc tgtaaaggag tcttgtttat cctctaatgg ccaggctttt   2100

gggacagcag catattgaaa tattttcacc aactaaagga aatagacaga aaaacaatga   2160

caatattcaa tcacagcagt aaatggcctt tgtgttgcaa tcccttctac cccatcagac   2220

agctcctaga aacattcctc ttacagttca tttctctaaa gcattttctg attcttagat   2280

aactccaatt tttgctacct ttatcttaga cattaacact atagcccaaa gcatagttac   2340

tttgctaaat cagaaagcaa ctgagttctt tgttttctcc tcaaatagaa tggggaacgt   2400

tcacaacatt ctcttaagtt ctaacaggaa taccattgtg gttatagaac tcagggctgc   2460

taaagcaact actctagacc catagttctt tttagttaga tgtattgaaa cagacaaaaa   2520

tattaacatc agaaaaagct cttgccaatt agaggatctt cttaatcctc agcaattaag   2580

tttggggttt gaggggggca ggtcattgtt acaacagaag taaatttggc atctatagaa   2640

atcaattatg atttttgaaa gatttatcta aatatatcaa tatagcatct ctttaatgtt   2700

agtcatttat tagaaagatc ctttatcctg atttgcttaa acctttcaat aaattgcact   2760

ttaaaggatt ataaataatc catttaaaaa ttcaagtaca cacatcagtg ttggttacta   2820

tgcagagaat gtcattgtgt atagtttcat gtaatctgtt atgtcagctg tattttttat   2880

taaaatcatg tcaagaaaac gtgttgtctg tagcttgaca ag                      2922


<210>  9547
<211>  578
<212>  PRT
<213>  Homosapiens

<400>  9547

Met Ala Phe Met Glu Lys Pro Pro Ala Gly Lys Val Leu Leu Asp Asp 
1               5                   10                  15      


Thr Val Pro Leu Thr Ala Ala Ile Glu Ala Ser Gln Ser Leu Gln Ser 
            20                  25                  30          


His Thr Glu Tyr Ile Ile Arg Val Gln Arg Gly Ile Ser Val Glu Asn 
        35                  40                  45              


Ser Trp Gln Ile Val Arg Arg Tyr Ser Asp Phe Asp Leu Leu Asn Asn 
    50                  55                  60                  


Ser Leu Gln Ile Ala Gly Leu Ser Leu Pro Leu Pro Pro Lys Lys Leu 
65                  70                  75                  80  


Ile Gly Asn Met Asp Arg Glu Phe Ile Ala Glu Arg Gln Lys Gly Leu 
                85                  90                  95      


Gln Asn Tyr Leu Asn Val Ile Thr Thr Asn His Ile Leu Ser Asn Cys 
            100                 105                 110         


Glu Leu Val Lys Lys Phe Leu Asp Pro Asn Asn Tyr Ser Ala Asn Tyr 
        115                 120                 125             


Thr Glu Ile Ala Leu Gln Gln Val Ser Met Phe Phe Arg Ser Glu Pro 
    130                 135                 140                 


Lys Trp Glu Val Val Glu Pro Leu Lys Asp Ile Gly Trp Arg Ile Arg 
145                 150                 155                 160 


Lys Lys Tyr Phe Leu Met Lys Ile Lys Asn Gln Pro Lys Glu Arg Leu 
                165                 170                 175     


Val Leu Ser Trp Ala Asp Leu Gly Pro Asp Lys Tyr Leu Ser Asp Lys 
            180                 185                 190         


Asp Phe Gln Cys Leu Ile Lys Leu Leu Pro Ser Cys Leu His Pro Tyr 
        195                 200                 205             


Ile Tyr Arg Val Thr Phe Ala Thr Ala Asn Glu Ser Ser Ala Leu Leu 
    210                 215                 220                 


Ile Arg Met Phe Asn Glu Lys Gly Thr Leu Lys Asp Leu Ile Tyr Lys 
225                 230                 235                 240 


Ala Lys Pro Lys Asp Pro Phe Leu Lys Lys Tyr Cys Asn Pro Lys Lys 
                245                 250                 255     


Ile Gln Gly Leu Glu Leu Gln Gln Ile Lys Thr Tyr Gly Arg Gln Ile 
            260                 265                 270         


Leu Glu Val Leu Lys Phe Leu His Asp Lys Gly Phe Pro Tyr Gly His 
        275                 280                 285             


Leu His Ala Ser Asn Val Met Leu Asp Gly Asp Thr Cys Arg Leu Leu 
    290                 295                 300                 


Asp Leu Glu Asn Ser Leu Leu Gly Leu Pro Ser Phe Tyr Arg Ser Tyr 
305                 310                 315                 320 


Phe Ser Gln Phe Arg Lys Ile Asn Thr Leu Glu Ser Val Asp Val His 
                325                 330                 335     


Cys Phe Gly His Leu Leu Tyr Glu Met Thr Tyr Gly Arg Pro Pro Asp 
            340                 345                 350         


Ser Val Pro Val Asp Ser Phe Pro Pro Ala Pro Ser Met Ala Val Val 
        355                 360                 365             


Ala Val Leu Glu Ser Thr Leu Ser Cys Glu Ala Cys Lys Asn Gly Met 
    370                 375                 380                 


Pro Thr Ile Ser Arg Leu Leu Gln Met Pro Leu Phe Ser Asp Val Leu 
385                 390                 395                 400 


Leu Thr Thr Ser Glu Lys Pro Gln Phe Lys Ile Pro Thr Lys Leu Lys 
                405                 410                 415     


Glu Ala Leu Arg Ile Ala Lys Glu Cys Ile Glu Lys Arg Leu Ile Glu 
            420                 425                 430         


Glu Gln Lys Gln Ile His Gln His Arg Arg Leu Thr Arg Ala Gln Ser 
        435                 440                 445             


His His Gly Ser Glu Glu Glu Arg Lys Lys Arg Lys Ile Leu Ala Arg 
    450                 455                 460                 


Lys Lys Ser Lys Arg Ser Ala Leu Glu Asn Ser Glu Glu His Ser Ala 
465                 470                 475                 480 


Lys Tyr Ser Asn Ser Asn Asn Ser Ala Gly Ser Gly Ala Ser Ser Pro 
                485                 490                 495     


Leu Thr Ser Pro Ser Ser Pro Thr Pro Pro Ser Thr Ser Gly Ile Ser 
            500                 505                 510         


Ala Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Ala Pro Leu 
        515                 520                 525             


Pro Pro Ala Ser Thr Glu Ala Pro Ala Gln Leu Ser Ser Gln Ala Val 
    530                 535                 540                 


Asn Gly Met Ser Arg Gly Ala Leu Leu Ser Ser Ile Gln Asn Phe Gln 
545                 550                 555                 560 


Lys Gly Thr Leu Arg Lys Ala Lys Thr Cys Asp His Ser Ala Pro Lys 
                565                 570                 575     


Ile Gly 
        


<210>  9548
<211>  1464
<212>  DNA
<213>  Homosapiens

<400>  9548
gttgacagcg gcggcggtgg aaccgggcgg gcggcgggag tcggcgcctc gggttcctac     60

ctcgcgtccc taggcggcgg cggccgggcg tcccgggatg gccttcatgg agaagccgcc    120

agccggcaag gtgctgctgg acgacacggt gccgctgaca gcagccatcg aggcgagcca    180

gagcctgcag tcccacacgg aatatattat tcgagtgcaa agaggaattt ctgtggaaaa    240

cagctggcag attgttagaa gatacagtga ctttgatttg cttaacaaca gcttacagat    300

tgcaggccta agtctacctc ttcctcccaa aaaattgatt ggtaacatgg atcgtgaatt    360

catagctgaa aggcagaaag gtcttcagaa ctatctcaac gtgatcacaa caaatcatat    420

cttgtctaat tgtgagctgg ttaagaagtt tttagatcca aacaactatt ccgcaaacta    480

tactgagatt gccttgcaac aggtttccat gttcttccga tcagaaccaa agtgggaggt    540

ggtggaacct ttgaaagaca taggttggag aataaggaag aaatatttct tgatgaagat    600

taaaaatcag ccaaaggaac ggctagtgtt aagctgggct gaccttggcc cagacaagta    660

tttgtcagat aaagattttc agtgtctaat caaacttctg ccttcttgtt tgcaccctta    720

catctatcgg gttacctttg ccacagctaa tgaatcctca gcgttgctaa ttaggatgtt    780

taacgaaaag ggaacattga aggatctgat ctacaaggca aaaccaaaag acccatttct    840

aaagaagtac tgcaacccta agaagattca gggcctggaa ctccagcaaa taaaaacata    900

tggacggcaa atattagagg tactgaagtt tcttcatgac aagggattcc cttatgggca    960

tcttcacgcc tccaatgtga tgctcgatgg ggacacttgc cggctgctgg accttgagaa   1020

ttccttattg ggcctgcctt ccttctaccg atcttatttt tcacaattca ggaaaatcaa   1080

tacattggaa agtgtggatg tccactgctt tggccactta ctgtatgaaa tgacttatgg   1140

acgaccgcca gactcggtgc ctgtggactc cttccctcct gccccgtcca tggctgtggt   1200

ggccgtgttg gagtctacgc tgtcttgtga agcctgtaaa aatggcatgc ctaccatctc   1260

ccggctctta cagatgccat tattcagcga tgttttacta accacttctg aaaaaccaca   1320

gtttaagatc cctacaaagt taaaagaggc attgagaatt gccaaagaat gtatagagaa   1380

gagactaatt gaggaacaga aacagattca ccagcatcga agactgacaa gagctcagtc   1440

ccaccatgga tctgaggagg aaag                                          1464


<210>  9549
<211>  454
<212>  PRT
<213>  Homosapiens

<400>  9549

Met Ala Phe Met Glu Lys Pro Pro Ala Gly Lys Val Leu Leu Asp Asp 
1               5                   10                  15      


Thr Val Pro Leu Thr Ala Ala Ile Glu Ala Ser Gln Ser Leu Gln Ser 
            20                  25                  30          


His Thr Glu Tyr Ile Ile Arg Val Gln Arg Gly Ile Ser Val Glu Asn 
        35                  40                  45              


Ser Trp Gln Ile Val Arg Arg Tyr Ser Asp Phe Asp Leu Leu Asn Asn 
    50                  55                  60                  


Ser Leu Gln Ile Ala Gly Leu Ser Leu Pro Leu Pro Pro Lys Lys Leu 
65                  70                  75                  80  


Ile Gly Asn Met Asp Arg Glu Phe Ile Ala Glu Arg Gln Lys Gly Leu 
                85                  90                  95      


Gln Asn Tyr Leu Asn Val Ile Thr Thr Asn His Ile Leu Ser Asn Cys 
            100                 105                 110         


Glu Leu Val Lys Lys Phe Leu Asp Pro Asn Asn Tyr Ser Ala Asn Tyr 
        115                 120                 125             


Thr Glu Ile Ala Leu Gln Gln Val Ser Met Phe Phe Arg Ser Glu Pro 
    130                 135                 140                 


Lys Trp Glu Val Val Glu Pro Leu Lys Asp Ile Gly Trp Arg Ile Arg 
145                 150                 155                 160 


Lys Lys Tyr Phe Leu Met Lys Ile Lys Asn Gln Pro Lys Glu Arg Leu 
                165                 170                 175     


Val Leu Ser Trp Ala Asp Leu Gly Pro Asp Lys Tyr Leu Ser Asp Lys 
            180                 185                 190         


Asp Phe Gln Cys Leu Ile Lys Leu Leu Pro Ser Cys Leu His Pro Tyr 
        195                 200                 205             


Ile Tyr Arg Val Thr Phe Ala Thr Ala Asn Glu Ser Ser Ala Leu Leu 
    210                 215                 220                 


Ile Arg Met Phe Asn Glu Lys Gly Thr Leu Lys Asp Leu Ile Tyr Lys 
225                 230                 235                 240 


Ala Lys Pro Lys Asp Pro Phe Leu Lys Lys Tyr Cys Asn Pro Lys Lys 
                245                 250                 255     


Ile Gln Gly Leu Glu Leu Gln Gln Ile Lys Thr Tyr Gly Arg Gln Ile 
            260                 265                 270         


Leu Glu Val Leu Lys Phe Leu His Asp Lys Gly Phe Pro Tyr Gly His 
        275                 280                 285             


Leu His Ala Ser Asn Val Met Leu Asp Gly Asp Thr Cys Arg Leu Leu 
    290                 295                 300                 


Asp Leu Glu Asn Ser Leu Leu Gly Leu Pro Ser Phe Tyr Arg Ser Tyr 
305                 310                 315                 320 


Phe Ser Gln Phe Arg Lys Ile Asn Thr Leu Glu Ser Val Asp Val His 
                325                 330                 335     


Cys Phe Gly His Leu Leu Tyr Glu Met Thr Tyr Gly Arg Pro Pro Asp 
            340                 345                 350         


Ser Val Pro Val Asp Ser Phe Pro Pro Ala Pro Ser Met Ala Val Val 
        355                 360                 365             


Ala Val Leu Glu Ser Thr Leu Ser Cys Glu Ala Cys Lys Asn Gly Met 
    370                 375                 380                 


Pro Thr Ile Ser Arg Leu Leu Gln Met Pro Leu Phe Ser Asp Val Leu 
385                 390                 395                 400 


Leu Thr Thr Ser Glu Lys Pro Gln Phe Lys Ile Pro Thr Lys Leu Lys 
                405                 410                 415     


Glu Ala Leu Arg Ile Ala Lys Glu Cys Ile Glu Lys Arg Leu Ile Glu 
            420                 425                 430         


Glu Gln Lys Gln Ile His Gln His Arg Arg Leu Thr Arg Ala Gln Ser 
        435                 440                 445             


His His Gly Ser Glu Glu 
    450                 


<210>  9550
<211>  473
<212>  DNA
<213>  Homosapiens

<400>  9550
actttgatgt aagatggaat tactgggttt ccattttagc aaattatgta atttgcgtgg     60

gtgtcattta agggtcatta tactatagaa tgctgcagga agtggctatt taaaaagctg    120

tatccattct gtagtcatgt ttgaggtcaa aaggattttg gagtgcttct ttgcagtgtt    180

tttcttctct ggaacatcag ctgtctttga agtcggtgtg gagaccagct ctcctggtag    240

ggcaggagac catcccacag cggagagtgt agacttcaaa aggcccggag aagggagaag    300

agaagcatgc atgatcatga cgctcatctc actgcaggga tcaaagcgtg tttgcaatgt    360

gtgcttcatc tcttcttttg cctgtgagcc agtgggagcc atggaaggtc ctggagcaga    420

gaagtagcgt ggtggtagat tccagccagg tcacttgttt tcagcattct ttt           473


<210>  9551
<211>  96
<212>  PRT
<213>  Homosapiens

<400>  9551

Met Phe Glu Val Lys Arg Ile Leu Glu Cys Phe Phe Ala Val Phe Phe 
1               5                   10                  15      


Phe Ser Gly Thr Ser Ala Val Phe Glu Val Gly Val Glu Thr Ser Ser 
            20                  25                  30          


Pro Gly Arg Ala Gly Asp His Pro Thr Ala Glu Ser Val Asp Phe Lys 
        35                  40                  45              


Arg Pro Gly Glu Gly Arg Arg Glu Ala Cys Met Ile Met Thr Leu Ile 
    50                  55                  60                  


Ser Leu Gln Gly Ser Lys Arg Val Cys Asn Val Cys Phe Ile Ser Ser 
65                  70                  75                  80  


Phe Ala Cys Glu Pro Val Gly Ala Met Glu Gly Pro Gly Ala Glu Lys 
                85                  90                  95      


<210>  9552
<211>  522
<212>  DNA
<213>  Homosapiens

<400>  9552
tgctagggct tgacacagca gcctccctgg catgccaaga tagggggtgt tgtgtcaaga     60

ggaggggcag aaaggagtgg gccctttggg gaagtggcag cagatggcag ggtttggtgg    120

caggctgaaa tccgtctgac tcaggtctgc cctgcagggc tgttagctct cctttccatg    180

cctgatgggc cttggtgctt tatcttctct tttatgtact tctgtctcaa aaaaaaaaaa    240

caaaaactaa gacataaaca cacacattag cctgggccta cacagtatca agatcatcag    300

tatgactgtc ttccacttcc acatcctgtc ccactggaag gtcttctggg gcaataacac    360

acatggagct ctcctatgat agcaatgcct tctggacacc tcctgaagga cctgtctgag    420

gctgttttac agttaccttt catttctaag tagaaggagt atactctgaa ataactataa    480

aaagcagtag gtttatttac accaccatac tacaaacaca tg                       522


<210>  9553
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  9553

Met Pro Asp Gly Pro Trp Cys Phe Ile Phe Ser Phe Met Tyr Phe Cys 
1               5                   10                  15      


Leu Lys Lys Lys Lys Gln Lys Leu Arg His Lys His Thr His 
            20                  25                  30  


<210>  9554
<211>  680
<212>  DNA
<213>  Homosapiens

<400>  9554
accaccaaaa caaaatcgtc tccttctctc atttgggtct cctgggatcc tgtcatctgt     60

gctcccacac actgtacctc aggaaaagat aggaaaggca aggagacgaa agctcagcaa    120

gtcctcagtt tccccagatc acacattcaa ggtctgtctg aatctatgat gtgtgcctgc    180

cacacttggt cctaagaagg tcatagcaag aacagcaaga gaagtaacag ccacagccat    240

ggagttccag atggttttag caccacctgt cagccatttg ctcttgggtt cttcagctat    300

gccacttccc ctctctccat gcctagatgg gttatgctga ctttctactt taactcttct    360

ttcaaagcca agcggtatca aaataatcac gtaattccat aagaagtgtt cttctgcagg    420

aagaaagtgt agctgagata gttaattttc cggacaacac aagagttccc tttcaaatca    480

ctgaagtcag aggcatctga taacaaatgg agtgtgccat ttttctgaag cgagagacaa    540

ccctggagct gattttctgt gtgtgtaaca atggtgtcta caggcagagc tgagcctccg    600

cacaggagtc tgcacatctt tgcgtctgag acagttggta caagtcagaa caattcactg    660

gaattcccca aggaattaaa                                                680


<210>  9555
<211>  33
<212>  PRT
<213>  Homosapiens

<400>  9555

Met Glu Phe Gln Met Val Leu Ala Pro Pro Val Ser His Leu Leu Leu 
1               5                   10                  15      


Gly Ser Ser Ala Met Pro Leu Pro Leu Ser Pro Cys Leu Asp Gly Leu 
            20                  25                  30          


Cys 
    


<210>  9556
<211>  627
<212>  DNA
<213>  Homosapiens

<400>  9556
ctaactgccc ttggcctgtt tctatgaagc tccctggtga gaagagtttg tcttttcctt     60

tgcaccccga agcccctgcc tgggctaaaa acgtgcagga atgcggcatt tggagaaatt    120

acacctctga gctgccagga tatattcaaa cagccaagaa cagaagttgg cccaactggg    180

acgcatccgt ggagcagcaa atatgcacac tcctggcagt catgcaagca agatggtcaa    240

cgtcagatac acaaggctgg cttgagcagt gttcactggg gaaaattcat ggacagggga    300

gcagaaacag aagaaaaacc acccacccca atgtcttgca cactgcaaca actctgtgaa    360

cactggtcat tattctactg ttgttattgg tgctctttac tggccaaagc tcagtgggag    420

gactactatc taacacaagt gccctgcagg acagaaagaa caagagtgct agagcttttg    480

tgcatctggg ccattttttc atttgacata tgaagaatct aagaacctgc aaggtggaag    540

tgacctgttc aaatagcagc aaagtcaaaa gcagatgtag ctctctatct ctgagcctct    600

aataaaatta atctaaatag ttgtcaa                                        627


<210>  9557
<211>  111
<212>  PRT
<213>  Homosapiens

<400>  9557

Met Lys Leu Pro Gly Glu Lys Ser Leu Ser Phe Pro Leu His Pro Glu 
1               5                   10                  15      


Ala Pro Ala Trp Ala Lys Asn Val Gln Glu Cys Gly Ile Trp Arg Asn 
            20                  25                  30          


Tyr Thr Ser Glu Leu Pro Gly Tyr Ile Gln Thr Ala Lys Asn Arg Ser 
        35                  40                  45              


Trp Pro Asn Trp Asp Ala Ser Val Glu Gln Gln Ile Cys Thr Leu Leu 
    50                  55                  60                  


Ala Val Met Gln Ala Arg Trp Ser Thr Ser Asp Thr Gln Gly Trp Leu 
65                  70                  75                  80  


Glu Gln Cys Ser Leu Gly Lys Ile His Gly Gln Gly Ser Arg Asn Arg 
                85                  90                  95      


Arg Lys Thr Thr His Pro Asn Val Leu His Thr Ala Thr Thr Leu 
            100                 105                 110     


<210>  9558
<211>  677
<212>  DNA
<213>  Homosapiens

<400>  9558
agagggtgca gttttgtaat cagaagcaga atgatcctat tgtagaaaga aggaatcgtg     60

accaatccag tggactgctc cagaaacatg acaaggagga ctttcctgcc tcttggagat    120

cagaggagga aatggcagca gaagccgcag ctctgcgggt ctactttcag tgacacagat    180

cctgaattcc agcaaaagag ctattgccaa ccagtttgaa gaccgccccc cgcctctccc    240

caagaggaac tgaatcagca tgaaaatgca gtttcttcat ctcaccatcc tgtattcttc    300

aaccagtgat cccccacctc ggtcactcca actcccttaa aatacctaga cctaaacggc    360

tcagacaggc agatttgagg tttccccctg tctccttatt cggcagcctt atgattaaac    420

ttccttctct gctgcaaccc tgtgtctcgg tgtattgact tgccatgaat taggcaacaa    480

acctattaca gttacagtta cttttttaaa ggaaattcaa tcgttggatt ggtccacctg    540

cttatttctt cccttttcaa aaaaaatgtc tacatattga atttttatac attaagtggt    600

tcatgaaacc cctgaaatgt gttagtaaat agggcaatta tgaaatattt ggacatagct    660

agactttaaa aattgtt                                                   677


<210>  9559
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  9559

Met Thr Arg Arg Thr Phe Leu Pro Leu Gly Asp Gln Arg Arg Lys Trp 
1               5                   10                  15      


Gln Gln Lys Pro Gln Leu Cys Gly Ser Thr Phe Ser Asp Thr Asp Pro 
            20                  25                  30          


Glu Phe Gln Gln Lys Ser Tyr Cys Gln Pro Val 
        35                  40              


<210>  9560
<211>  1230
<212>  DNA
<213>  Homosapiens

<400>  9560
ctctgtccgg tcacaggact ttttgccctc tgttcccggg tccctcaggc ggccacccag     60

tgggcacact cccaggcggc gctccggccc cgcgctccct ccctctgcct ttcattccca    120

gctgtcaaca tcctggaagc tttgaagctc aggaaagaag agaaatccac tgagaacagt    180

ctgtaaaggt ccgtagtgct atctacatcc agacggtgga agggagagaa agagaaagaa    240

ggtatcctag gaatacctgc ctgcttagac cctctataaa agctctgtgc atcctgccac    300

tgaggactcc gaagaggtag cagtcttctg aaagacttca actgtgagga catgtcgttc    360

agatttggcc aacatctcat caagccctct gtagtgtttc tcaaaacaga actgtccttc    420

gctcttgtga ataggaaacc tgtggtacca ggacatgtcc ttgtgtgccc gctgcggcca    480

gtggagcgct tccatgacct gcgtcctgat gaagtggccg atttgtttca gacgacccag    540

agagtcggga cagtggtgga aaaacatttc catgggacct ctctcacctt ttccatgcag    600

gatggccccg aagccggaca gactgtgaag cacgttcacg tccatgttct tcccaggaag    660

gctggagact ttcacaggaa tgacagcatc tatgaggagc tccagaaaca tgacaaggag    720

gactttcctg cctcttggag atcagaggag gaaatggcag cagaagccgc agctctgcgg    780

gtctactttc agtgacacag atcctgaatt ccagcaaaag agctattgcc aaccagtttg    840

aagaccgccc cccgcctctc cccaagagga actgaatcag catgaaaatg cagtttcttc    900

atctcaccat cctgtattct tcaaccagtg atcccccacc tcggtcactc caactccctt    960

aaaataccta gacctaaacg gctcagacag gcagatttga ggtttccccc tgtctcctta   1020

ttcggcagcc ttatgattaa acttccttct ctgctgcaac cctgtgtctc ggtgtattga   1080

cttgccatga attaggcaac aaacctatta cagttacagt tactttttta aaggaaattc   1140

aatcgttgga ttggtccacc tgcttatttc ttcccttttc aaaaaaaatg tctacatatt   1200

gaatttttat acattaagtg gttcatgaaa                                    1230


<210>  9561
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  9561

Met Ser Phe Arg Phe Gly Gln His Leu Ile Lys Pro Ser Val Val Phe 
1               5                   10                  15      


Leu Lys Thr Glu Leu Ser Phe Ala Leu Val Asn Arg Lys Pro Val Val 
            20                  25                  30          


Pro Gly His Val Leu Val Cys Pro Leu Arg Pro Val Glu Arg Phe His 
        35                  40                  45              


Asp Leu Arg Pro Asp Glu Val Ala Asp Leu Phe Gln Thr Thr Gln Arg 
    50                  55                  60                  


Val Gly Thr Val Val Glu Lys His Phe His Gly Thr Ser Leu Thr Phe 
65                  70                  75                  80  


Ser Met Gln Asp Gly Pro Glu Ala Gly Gln Thr Val Lys His Val His 
                85                  90                  95      


Val His Val Leu Pro Arg Lys Ala Gly Asp Phe His Arg Asn Asp Ser 
            100                 105                 110         


Ile Tyr Glu Glu Leu Gln Lys His Asp Lys Glu Asp Phe Pro Ala Ser 
        115                 120                 125             


Trp Arg Ser Glu Glu Glu Met Ala Ala Glu Ala Ala Ala Leu Arg Val 
    130                 135                 140                 


Tyr Phe Gln 
145         


<210>  9562
<211>  411
<212>  DNA
<213>  Homosapiens

<400>  9562
agcagaatga tcctattgta gaaagaagga atcgtgacca atccagtgga ctgctccaga     60

aacatgacaa ggaggacttt cctgcctctt ggagatcaga ggaggaaatg gcagcagaag    120

ccgcagctct gcgggtctac tttcagtgac acagatcctg aattccagca aaagagctat    180

tgccaaccag tttgaagacc gccccccgcc tctccccaag aggaactgaa tcagcatgaa    240

aatgcagttt cttcatctca ccatcctgta ttcttcaacc agtgatcccc cacctcggtc    300

actccaactc ccttaaaata cctagaccta aacggctcag acaggcagat ttgaggtttc    360

cccctgtctc cttattcggc agccttatga ttaaacttcc ttctctgctg c             411


<210>  9563
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  9563

Met Thr Arg Arg Thr Phe Leu Pro Leu Gly Asp Gln Arg Arg Lys Trp 
1               5                   10                  15      


Gln Gln Lys Pro Gln Leu Cys Gly Ser Thr Phe Ser Asp Thr Asp Pro 
            20                  25                  30          


Glu Phe Gln Gln Lys Ser Tyr Cys Gln Pro Val 
        35                  40              


<210>  9564
<211>  2992
<212>  DNA
<213>  Homosapiens

<400>  9564
aatcactgca ttcagttttg agatttgtca tcaaacaaac tgcacccttg ccatttgtaa     60

ctttgtggca ccacaggata ttctaatctc atcttgttcc tgtcctgtcc cattaatgga    120

gccaaccact tctccaagga ggtctggttc cttttttatt tttatttttt ggagaatggt    180

atttagaaac caagatctgg acatcagagc tccagaaaca tgacaaggag gactttcctg    240

cctcttggag atcagaggag gaaatggcag cagaagccgc agctctgcgg gtctactttc    300

agtgacacag gtaaagactg catttcgtca ttacccagac cctcccgtgg gcctcaggaa    360

agaggctgca ctctcagaat ggggatgcac aaaaacacct tcaccagcat ccttgggtgg    420

tggctgcaaa ggacaaagag ctggagggga gaaaaccctg gcccttgagt actgtattcc    480

cagcctccca gtctcttcca actctcctgc ctcttcactc tcttcttcca agccagtgcc    540

cccagcccac caccaccttt ctccagtctt tcctgcggtg gtgctcctcc agaatccaat    600

gttcacaaag cagaccttct gtcatgcaca acttcttgtt taaaaggtca accccaactt    660

aacttaaagg tgtgacatgg cccttaggct caagtctgtc tgcaaagccc tgtaaaccag    720

ctttctctgc ctccctaaca cgcccccggg caaactcctc tgctttcact gagtggactc    780

ttctcttcag ttgctatttg gtaaattgcc cttcatgttt ccctttatgt tcggctccta    840

ggaagctcag gccacaggga aaagtcaagg cttgatagaa ttaatctttg tcttaatgat    900

gactaactgt tgagagatca taggtttaag actctggtag aaagatagct atagccaatt    960

tccttgtcaa aatgcttcta ctccaaattt ttatgcagtg tctaacgagc tcatgcctag   1020

atctatctgg caatctatat tatccctcct agtctcagtt cacatagtag actgctggaa   1080

tgactgaggg tgatgtttgg cctgtaaaca aaaagtgtta aagaaggcca ggtacagtgg   1140

ctcatgccta taatcccaac tacttgggaa gctgaggcag gagaactgct tgaacctggg   1200

aggcagaggt tgcagtgagc tgagatcatg ccactgcatt ccagcctggg tgacagagca   1260

agactcagtt tcaaaaaaac aggagagaga gagagagaaa tgtatctatc tctctgaaat   1320

ttgtttataa atatagggtt accatgcaat actggcatat atctagacta aaaaaattac   1380

ttgtttatct gaaattcaaa tttaactggt atcttgtatt tttttctggc aaacctgtta   1440

ataaactccc atggacccca gttacagatc ctctcctata aatagtttct tttttgtttt   1500

tagaattaga taattccaaa ttaaaattag gcaattcttc atctgacctg tgaataaata   1560

tgttcatgtt ataagttgca gaagtagatc agacacaaat aaaaaacaaa attagtgaat   1620

aaatgctgtt agcaattgat tggaaaaaat tgtatcaacc acttagtgat catgattttt   1680

agctagaaaa cacattcatt gtattctgat ttcaccttga aatgtaagta agtctttact   1740

ggatagcttt aaatatatgt gcacttggcc tttctctccc cagccctctt tttagagtat   1800

tctaaatagt taaagaccca gactaccttg ccccctattg ttgttcaaat atggtgttgt   1860

actcagatcc ttgcattcta gaaagcttat ttcattctcc catgtcataa gtttgtcagc   1920

tctgcactca gttgcctggg gggatatggc aagtgctata acagaggctg tctttcatat   1980

tttattttga accttttcca ctgttcacca tctctctctc gttttttaag gatcaagcta   2040

gtttagttta cctaagaaca taggcctatg ggcatgacta caaacctctt tctgttcctc   2100

ttatgaaggc cagtatgtca ttttagagtg ccctgttcaa atttaaatgg ggtgacaata   2160

cctcagactt gactgcctag gttgaatttt ttctcctggg ttttctatgc agtgggtatt   2220

ttcaggtaga ggctagaaag ctttagcctt tttcccaagg cttgctgaat tgtaggagtt   2280

ttgtcttaga atgctttttc tagacacttt aagaacttta agaagattca aacttattac   2340

ccaaatttcc tgtaggcttt gttttgtcag tttttgcttc tgtcttgcct ggaggcctga   2400

cacctcctgt cttccaggta aattgacttc ccttgtacat cttaccagaa agatatttac   2460

cctaacttgt tacacaaact attgccacag tacctgtgga tttttaagtt aactaacatg   2520

tgtatttctc tttaaaggtt ttgtgcacag accaaacaaa tcaccctcag tcttcccagc   2580

agtcagatgt ggtaactaag actaggacgg ataatatagg ttgtgaggtg gcaaacaact   2640

tagggtccta agattttgcc aagactgtca tcattacctg gagtataatg ggactaacta   2700

tacctccctt taaggacaat ggaaacattc tattgaaacc atcctcacag ggttaacaag   2760

aattagatgc tgggttctgg acagaaatat agttgtaatt aagcattaat caggctgcac   2820

tttggcccac ttttcatctc accatcctgt attcttcaac cagtgatccc ccacctcggt   2880

cactccaact cccttaaaat acctagacct aaacggctca gacaggcaga tttgaggttt   2940

ccccctgtct ccttattcgg cagccttatg attaaacttc cttctctgct gc           2992


<210>  9565
<211>  35
<212>  PRT
<213>  Homosapiens

<400>  9565

Met Glu Pro Thr Thr Ser Pro Arg Arg Ser Gly Ser Phe Phe Ile Phe 
1               5                   10                  15      


Ile Phe Trp Arg Met Val Phe Arg Asn Gln Asp Leu Asp Ile Arg Ala 
            20                  25                  30          


Pro Glu Thr 
        35  


<210>  9566
<211>  1068
<212>  DNA
<213>  Homosapiens

<400>  9566
tccccgctct gctctgtccg gtcacaggac tttttgccct ctgttcccgg gtccctcagg     60

cggccaccca gtgggcacac tcccaggcgg cgctccggcc ccgcgctccc tccctctgcc    120

tttcattccc agctgtcaac atcctggaag ctttgaagct caggaaagaa gagaaatcca    180

ctgagaacag tctgtaaagg tccgtagtgc tatctacatc cagacggtgg aagggagaga    240

aagagaaaga aggtatccta ggaatacctg cctgcttaga ccctctataa aagctctgtg    300

catcctgcca ctgaggactc cgaagaggta gcagtcttct gaaagacttc aactgtgagg    360

acatgtcgtt cagatttggc caacatctca tcaagccctc tgtagtgttt ctcaaaacag    420

aactgtcctt cgctcttgtg aataggaaac ctgtggtacc aggacatgtc cttgtgtgcc    480

cgctgcggcc agtggagcgc ttccatgacc tgcgtcctga tgaagtggcc gatttgtttc    540

agacgaccca gagagtcggg acagtggtgg aaaaacattt ccatgggacc tctctcacct    600

tttccatgca ggatggcccc gaagccggac agactgtgaa gcacgttcac gtccatgttc    660

ttcccaggaa ggctggagac tttcacagga atgacagcat ctatgaggag ctccagaaac    720

atgacaagga ggactttcct gcctcttgga gatcagagga ggaaatggca gcagaagccg    780

cagctctgcg ggtctacttt cagtgacaca gatcctgaat tccagcaaaa gagctattgc    840

caaccagttt gaagaccgcc ccccgcctct ccccaagagg aactgaatca gcatgaaaat    900

gcagtttctt catctcacca tcctgtattc ttcaaccagt gatcccccac ctcggtcact    960

ccaactccct taaaatacct agacctaaac ggctcagaca ggcagatttg aggtttcccc   1020

ctgtctcctt attcggcagc cttatgatta aacttccttc tctgctgc                1068


<210>  9567
<211>  147
<212>  PRT
<213>  Homosapiens

<400>  9567

Met Ser Phe Arg Phe Gly Gln His Leu Ile Lys Pro Ser Val Val Phe 
1               5                   10                  15      


Leu Lys Thr Glu Leu Ser Phe Ala Leu Val Asn Arg Lys Pro Val Val 
            20                  25                  30          


Pro Gly His Val Leu Val Cys Pro Leu Arg Pro Val Glu Arg Phe His 
        35                  40                  45              


Asp Leu Arg Pro Asp Glu Val Ala Asp Leu Phe Gln Thr Thr Gln Arg 
    50                  55                  60                  


Val Gly Thr Val Val Glu Lys His Phe His Gly Thr Ser Leu Thr Phe 
65                  70                  75                  80  


Ser Met Gln Asp Gly Pro Glu Ala Gly Gln Thr Val Lys His Val His 
                85                  90                  95      


Val His Val Leu Pro Arg Lys Ala Gly Asp Phe His Arg Asn Asp Ser 
            100                 105                 110         


Ile Tyr Glu Glu Leu Gln Lys His Asp Lys Glu Asp Phe Pro Ala Ser 
        115                 120                 125             


Trp Arg Ser Glu Glu Glu Met Ala Ala Glu Ala Ala Ala Leu Arg Val 
    130                 135                 140                 


Tyr Phe Gln 
145         


<210>  9568
<211>  1291
<212>  DNA
<213>  Homosapiens

<400>  9568
atagcccaca ccttgacagt acattcagtc actggatgat tttgtattga agtctgtaag     60

ttcaagaact aaaacaatcc aaaacggcta ctacaggtga agttgagagc aatggcccaa    120

cctcagctgt atctaccaga accctttaag attgcctaca gaaaagttgg acagtgccga    180

agattccagc aactcaagaa gaaaaatggc tcattcaaaa ggaaggggat agaaagatgg    240

catagagctg tgtctaccaa cttactaaaa caaaatgtat tggtccctaa agaggaatca    300

tccagtgata gtgacatggg atttcatgaa agccagcaaa atcagaaaag taatttgaag    360

acgaaagtga agactgcttt tgggaggatg ctgtcctaca agtatagaag caagccagca    420

tgtgccagcc aagagggctc cactgaccat aaagaagccc tcctgtcaaa cacgcagagc    480

cttctcccta ggattgtcaa ggagttttca tctcccaagt tatttacagc aaaaatgaga    540

aagctctcag agaatgcgac tatacaactt gatgttgtag aggcagagac agaggagata    600

acccagggaa acacactcct tcgggccagg agaaccacca agcggttatc tgtgacatct    660

cttccttcag gactgcaaaa ggggccatat tcaccaaaaa agagaccaca ctttccagca    720

cttaaaaaaa agaagcgtgg catggaaaac atccttcgaa aatcagattt gacagtagga    780

aagcttcaaa tgcaggtgga tgacctcata gaaacagtga ctgataaatc catgaagcta    840

ctggcccaaa gacatgctga gcttcaacag tgtgagtttc tgggggatga aattcttcag    900

tcttctaaac agttccagag gatatccaag agaaccatga ggaagtataa attaaaaaat    960

atgaccacaa aaggacctgg agacagctga cctgagactc cttgaggaac acaggaaaag   1020

gtcttcagac aataacttaa ccaattacca atcagaaaat cgactccacc tatgagctgg   1080

aagtccttcc caccccccac cttcaagctg tcctgctttt ctgtactgaa ccaatataca   1140

tcttacgtgt attcattgat gtctgcctgt aacttctgtc cccctaaaat gcataaaatc   1200

agctgtaatt caaccacctt cggcacatct caggacctcc tgatgctgtg gcatgtcttt   1260

aaccttggca aaataaactc ctaaattgat t                                  1291


<210>  9569
<211>  292
<212>  PRT
<213>  Homosapiens

<400>  9569

Met Ala Gln Pro Gln Leu Tyr Leu Pro Glu Pro Phe Lys Ile Ala Tyr 
1               5                   10                  15      


Arg Lys Val Gly Gln Cys Arg Arg Phe Gln Gln Leu Lys Lys Lys Asn 
            20                  25                  30          


Gly Ser Phe Lys Arg Lys Gly Ile Glu Arg Trp His Arg Ala Val Ser 
        35                  40                  45              


Thr Asn Leu Leu Lys Gln Asn Val Leu Val Pro Lys Glu Glu Ser Ser 
    50                  55                  60                  


Ser Asp Ser Asp Met Gly Phe His Glu Ser Gln Gln Asn Gln Lys Ser 
65                  70                  75                  80  


Asn Leu Lys Thr Lys Val Lys Thr Ala Phe Gly Arg Met Leu Ser Tyr 
                85                  90                  95      


Lys Tyr Arg Ser Lys Pro Ala Cys Ala Ser Gln Glu Gly Ser Thr Asp 
            100                 105                 110         


His Lys Glu Ala Leu Leu Ser Asn Thr Gln Ser Leu Leu Pro Arg Ile 
        115                 120                 125             


Val Lys Glu Phe Ser Ser Pro Lys Leu Phe Thr Ala Lys Met Arg Lys 
    130                 135                 140                 


Leu Ser Glu Asn Ala Thr Ile Gln Leu Asp Val Val Glu Ala Glu Thr 
145                 150                 155                 160 


Glu Glu Ile Thr Gln Gly Asn Thr Leu Leu Arg Ala Arg Arg Thr Thr 
                165                 170                 175     


Lys Arg Leu Ser Val Thr Ser Leu Pro Ser Gly Leu Gln Lys Gly Pro 
            180                 185                 190         


Tyr Ser Pro Lys Lys Arg Pro His Phe Pro Ala Leu Lys Lys Lys Lys 
        195                 200                 205             


Arg Gly Met Glu Asn Ile Leu Arg Lys Ser Asp Leu Thr Val Gly Lys 
    210                 215                 220                 


Leu Gln Met Gln Val Asp Asp Leu Ile Glu Thr Val Thr Asp Lys Ser 
225                 230                 235                 240 


Met Lys Leu Leu Ala Gln Arg His Ala Glu Leu Gln Gln Cys Glu Phe 
                245                 250                 255     


Leu Gly Asp Glu Ile Leu Gln Ser Ser Lys Gln Phe Gln Arg Ile Ser 
            260                 265                 270         


Lys Arg Thr Met Arg Lys Tyr Lys Leu Lys Asn Met Thr Thr Lys Gly 
        275                 280                 285             


Pro Gly Asp Ser 
    290         


<210>  9570
<211>  992
<212>  DNA
<213>  Homosapiens

<400>  9570
gcctcctcct ccatggctgt ttacccggct gcattgtggg agtttgacct ccgccgccgc     60

caaccgccgc ctcagcttgc gccgccgccg ccgccgccgc cgccgcgcac gccatgggag    120

ccgtgactga cgacgaagtt atacggaagc gtctcctcat tgatggagat ggtgctggag    180

atgatcggag aattaatctg ctagtgaaga gtttcattaa atggtgcaac tctgggtccc    240

aggaagaggg atatagccag taccaacgta tgctgagcac gctgtctcaa tgtgaatttt    300

caatgggcaa aactttacta gtatatgata tgaatctcag agaaatggaa aattatgaaa    360

aaatttacaa ggaaatagaa tgtagcatag ctggagcaca tgaaaaaatt gctgagtgca    420

aaaagcaaat tcttcaagca aaacgaatac gaaaaaatcg ccaagaatat gatgctttgg    480

caaaagtgat tcagcaccat ccagacaggc atgagacatt aaaggaacta gaggctctgg    540

gaaaagaatt agagcatctt tcacacatta aagaaagtgt tgaagataag ctggaattga    600

gacggaaaca gtttcatgtt cttcttagta ccatccatga acttcagcaa acattggaaa    660

atgatgaaaa actctcagag gtagaagaag ctcaggaagc aagcatggaa acagatccta    720

agccatagac aggctaattg cccaccactc ccaggaatat tgaaatagct acatgaccat    780

aatgtgttta aaatgtggta tgctcttgag atatttaaag ttttggcagt aaaatactct    840

gtttttaagt atgaatgtat ttcattcata tttcctctca caaaggaaaa tgacttcagt    900

atagatttgt ttttattaaa atgcattttt tattcttaag tggtaggaag caacatccaa    960

aaatgcttaa taaaatgctt ttaagctgca ta                                  992


<210>  9571
<211>  204
<212>  PRT
<213>  Homosapiens

<400>  9571

Met Gly Ala Val Thr Asp Asp Glu Val Ile Arg Lys Arg Leu Leu Ile 
1               5                   10                  15      


Asp Gly Asp Gly Ala Gly Asp Asp Arg Arg Ile Asn Leu Leu Val Lys 
            20                  25                  30          


Ser Phe Ile Lys Trp Cys Asn Ser Gly Ser Gln Glu Glu Gly Tyr Ser 
        35                  40                  45              


Gln Tyr Gln Arg Met Leu Ser Thr Leu Ser Gln Cys Glu Phe Ser Met 
    50                  55                  60                  


Gly Lys Thr Leu Leu Val Tyr Asp Met Asn Leu Arg Glu Met Glu Asn 
65                  70                  75                  80  


Tyr Glu Lys Ile Tyr Lys Glu Ile Glu Cys Ser Ile Ala Gly Ala His 
                85                  90                  95      


Glu Lys Ile Ala Glu Cys Lys Lys Gln Ile Leu Gln Ala Lys Arg Ile 
            100                 105                 110         


Arg Lys Asn Arg Gln Glu Tyr Asp Ala Leu Ala Lys Val Ile Gln His 
        115                 120                 125             


His Pro Asp Arg His Glu Thr Leu Lys Glu Leu Glu Ala Leu Gly Lys 
    130                 135                 140                 


Glu Leu Glu His Leu Ser His Ile Lys Glu Ser Val Glu Asp Lys Leu 
145                 150                 155                 160 


Glu Leu Arg Arg Lys Gln Phe His Val Leu Leu Ser Thr Ile His Glu 
                165                 170                 175     


Leu Gln Gln Thr Leu Glu Asn Asp Glu Lys Leu Ser Glu Val Glu Glu 
            180                 185                 190         


Ala Gln Glu Ala Ser Met Glu Thr Asp Pro Lys Pro 
        195                 200                 


<210>  9572
<211>  892
<212>  DNA
<213>  Homosapiens

<400>  9572
gcggccgcgg gcgccgccgc ctcctcctcc atggctgttt acccggctgc attgtgggag     60

tttgacctcc gccgccgcca accgccgcct cagcttgcgc cgccgccgcc gccgccgccg    120

ccgcgcacgc catgggagcc gtgactgacg atatagccag taccaacgta tgctgagcac    180

gctgtctcaa tgtgaatttt caatgggcaa aactttacta gtatatgata tgaatctcag    240

agaaatggaa aattatgaaa aaatttacaa ggaaatagaa tgtagcatag ctggagcaca    300

tgaaaaaatt gctgagtgca aaaagcaaat tcttcaagca aaacgaatac gaaaaaatcg    360

ccaagaatat gatgctttgg caaaagtgat tcagcaccat ccagacaggc atgagacatt    420

aaaggaacta gaggctctgg gaaaagaatt agagcatctt tcacacatta aagaaagtgt    480

tgaagataag ctggaattga gacggaaaca gtttcatgtt cttcttagta ccatccatga    540

acttcagcaa acattggaaa atgatgaaaa actctcagag gtagaagaag ctcaggaagc    600

aagcatggaa acagatccta agccatagac aggctaattg cccaccactc ccaggaatat    660

tgaaatagct acatgaccat aatgtgttta aaatgtggta tgctcttgag atatttaaag    720

ttttggcagt aaaatactct gtttttaagt atgaatgtat ttcattcata tttcctctca    780

caaaggaaaa tgacttcagt atagatttgt ttttattaaa atgcattttt tattcttaag    840

tggtaggaag caacatccaa aaatgcttaa taaaatgctt ttaagctgca ta            892


<210>  9573
<211>  152
<212>  PRT
<213>  Homosapiens

<400>  9573

Met Leu Ser Thr Leu Ser Gln Cys Glu Phe Ser Met Gly Lys Thr Leu 
1               5                   10                  15      


Leu Val Tyr Asp Met Asn Leu Arg Glu Met Glu Asn Tyr Glu Lys Ile 
            20                  25                  30          


Tyr Lys Glu Ile Glu Cys Ser Ile Ala Gly Ala His Glu Lys Ile Ala 
        35                  40                  45              


Glu Cys Lys Lys Gln Ile Leu Gln Ala Lys Arg Ile Arg Lys Asn Arg 
    50                  55                  60                  


Gln Glu Tyr Asp Ala Leu Ala Lys Val Ile Gln His His Pro Asp Arg 
65                  70                  75                  80  


His Glu Thr Leu Lys Glu Leu Glu Ala Leu Gly Lys Glu Leu Glu His 
                85                  90                  95      


Leu Ser His Ile Lys Glu Ser Val Glu Asp Lys Leu Glu Leu Arg Arg 
            100                 105                 110         


Lys Gln Phe His Val Leu Leu Ser Thr Ile His Glu Leu Gln Gln Thr 
        115                 120                 125             


Leu Glu Asn Asp Glu Lys Leu Ser Glu Val Glu Glu Ala Gln Glu Ala 
    130                 135                 140                 


Ser Met Glu Thr Asp Pro Lys Pro 
145                 150         


<210>  9574
<211>  945
<212>  DNA
<213>  Homosapiens

<400>  9574
gcggccgccc ccggggagta ccgggagcgc ggggagcgcg ggtcccgcgc cgccgccgcg     60

cacgccatgg gagccgtgac tgacgacgaa gttatacgga agcgtctcct cattgatgga    120

gatggtgctg gagatgatcg gagaattaat ctgctagtga agagtttcat taaatggtgc    180

aactctgggt cccaggaaga gggatatagc cagtaccaac gtatgctgag cacgctgtct    240

caatgtgaat tttcaatggg caaaacttta ctagtatatg atatgaatct cagagaaatg    300

gaaaattatg aaaaaattta caaggaaata gaatgtagca tagctggagc acatgaaaaa    360

attgctgagt gcaaaaagca aattcttcaa gcaaaacgaa tacgaaaaaa tcgccaagaa    420

tatgatgctt tggcaaaagt gattcagcac catccagaca ggcatgagac attaaaggaa    480

ctagaggctc tgggaaaaga attagagcat ctttcacaca ttaaagaaag tgttgaagat    540

aagctggaat tgagacggaa acagtttcat gttcttctta gtaccatcca tgaacttcag    600

caaacattgg aaaatgatga aaaactctca gaggtagaag aagctcagga agcaagcatg    660

gaaacagatc ctaagccata gacaggctaa ttgcccacca ctcccaggaa tattgaaata    720

gctacatgac cataatgtgt ttaaaatgtg gtatgctctt gagatattta aagttttggc    780

agtaaaatac tctgttttta agtatgaatg tatttcattc atatttcctc tcacaaagga    840

aaatgacttc agtatagatt tgtttttatt aaaatgcatt ttttattctt aagtggtagg    900

aagcaacatc caaaaatgct taataaaatg cttttaagct gcata                    945


<210>  9575
<211>  204
<212>  PRT
<213>  Homosapiens

<400>  9575

Met Gly Ala Val Thr Asp Asp Glu Val Ile Arg Lys Arg Leu Leu Ile 
1               5                   10                  15      


Asp Gly Asp Gly Ala Gly Asp Asp Arg Arg Ile Asn Leu Leu Val Lys 
            20                  25                  30          


Ser Phe Ile Lys Trp Cys Asn Ser Gly Ser Gln Glu Glu Gly Tyr Ser 
        35                  40                  45              


Gln Tyr Gln Arg Met Leu Ser Thr Leu Ser Gln Cys Glu Phe Ser Met 
    50                  55                  60                  


Gly Lys Thr Leu Leu Val Tyr Asp Met Asn Leu Arg Glu Met Glu Asn 
65                  70                  75                  80  


Tyr Glu Lys Ile Tyr Lys Glu Ile Glu Cys Ser Ile Ala Gly Ala His 
                85                  90                  95      


Glu Lys Ile Ala Glu Cys Lys Lys Gln Ile Leu Gln Ala Lys Arg Ile 
            100                 105                 110         


Arg Lys Asn Arg Gln Glu Tyr Asp Ala Leu Ala Lys Val Ile Gln His 
        115                 120                 125             


His Pro Asp Arg His Glu Thr Leu Lys Glu Leu Glu Ala Leu Gly Lys 
    130                 135                 140                 


Glu Leu Glu His Leu Ser His Ile Lys Glu Ser Val Glu Asp Lys Leu 
145                 150                 155                 160 


Glu Leu Arg Arg Lys Gln Phe His Val Leu Leu Ser Thr Ile His Glu 
                165                 170                 175     


Leu Gln Gln Thr Leu Glu Asn Asp Glu Lys Leu Ser Glu Val Glu Glu 
            180                 185                 190         


Ala Gln Glu Ala Ser Met Glu Thr Asp Pro Lys Pro 
        195                 200                 


<210>  9576
<211>  673
<212>  DNA
<213>  Homosapiens

<400>  9576
ccgtgtctca ttaaaaaaaa aaaaaacaca cacacacata cacactgtct ctgttatgtg     60

cagaatgatt agaggaagag aaaatgagga gctaagtttc ctcgccactt actaacgttt    120

acgtagtgct gttaggtatt attctaattg ttatccccat tttacagatg aaacagacac    180

aggttagctt gcctaaggtc gcacagatag tagttataga gggtcaaagg cagggagacc    240

acctgccgag ttcctgctct tcactattat gcgtcctgtg tctgctactt ctgcagtggc    300

cctggtgaga gacaatgagg acttctctct taatctgcac aggttgcctt ttcctgcctt    360

ttctatcagg tgacactcca cttattcctc aagacccacc tcaaaaatcc cctcttttct    420

ttcctagaag tagttgacct tctgcctact agccatatta ttttatgcat attgctgctg    480

tcacccttaa tacgttattt atatgcctta tgctagaaaa catttaaggc agttcactgt    540

aatgagaaaa tataaaaatt aaacggatta gaaaacaaga caaaaagaac attgagatta    600

ggaaaaataa agggaagtca gaagtggggt gatcctcaaa atgcaggagg ataaagtcta    660

gtacattaat taa                                                       673


<210>  9577
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  9577

Met Arg Thr Ser Leu Leu Ile Cys Thr Gly Cys Leu Phe Leu Pro Phe 
1               5                   10                  15      


Leu Ser Gly Asp Thr Pro Leu Ile Pro Gln Asp Pro Pro Gln Lys Ser 
            20                  25                  30          


Pro Leu Phe Phe Pro Arg Ser Ser 
        35                  40  


<210>  9578
<211>  3513
<212>  DNA
<213>  Homosapiens

<400>  9578
gaaaaagggt gaaagagaaa cttggcgacc tcccggagga gttcgcgaag cgaccaggag     60

cgtgttgcca tcgtcctcac ccggcaccca attccaccac agagtcggga tttcgtcggt    120

gatcgtgatg gggtgctttt atttttctct ttgattttca aaaaatgtct atgtgactgt    180

ccctatctta aggggaagtt gaaagtgggg gcgggggtgc tcaatgagaa acgttgcctt    240

gtgtgtagtt gtttggagca cactgcaaat tatattggca tctctttcca aaagtcactt    300

tgattcaact tcgatagctt tctcgtaaat ggcacgttta ggtggtgaga ggtggatgag    360

gaaacaggca ccagtgcagc tgatttgacc tccagtggga tagatacgat tagcaccagg    420

atcgtgtctc attttgaacc cagatctgaa cagaattaag acgaacgagc tttcacaatt    480

gcagcagatg aagatccatt ggtaaattga tcaggatttt tggcctaccc tccaaagaaa    540

aggagcggaa agaatgtcgg agcgggccgc ggatgacgtc aggggggagc cgcgccgcgc    600

ggcggcggcg gcgggcggag cagcggccgc ggccgcccgg cagcagcagc agcagcagca    660

gcagcagcag ccgccgcctc cgcagcccca gcggcagcag cacccgccac cgccgccacg    720

gcgcacacgg ccggaggacg gcgggcccgg cgccgcctcc acctcggccg ccgcaatggc    780

gacggtcggg gagcgcaggc ctctgcccag tcctgaagtg atgctgggac agtcgtggaa    840

tctgtgggtt gaggcttcca aacttcctgg gaaggacggg acagaattgg acgaaagttt    900

caaggagttt gggaaaaacc gcgaagtcat ggggctctgt cgggaagaca tgccaatatt    960

tggtttctgt ccagcccatg atgatttcta cttggtggtg tgtaacgact gtaatcaggt   1020

tgtcaaaccg caggcatttc aatcacatta tgaaagaaga catagctcat ccagcaagcc   1080

gcctttggcc gttcctccca cttcagtatt ttccttcttc ccttctctgt ccaaaagcaa   1140

aggaggcagt gcaagtggaa gcaaccgttc ttccagtgga ggtgttctta gcgcatcctc   1200

atcaagttcc aagttgttga aatcacccaa agagaaactg cagctcaggg ggaacaccag   1260

gccaatgcat cccattcagc aaagtagagt tccccatggt agaatcatga caccctctgt   1320

gaaagtggaa aagattcatc cgaaaatgga tggcacacta ctgaaatctg cggtggggcc   1380

aacctgtcct gctactgtga gttccttagt caagcctggc cttaactgcc cctcaatacc   1440

aaagccaacc ttgccttcac ctggacagat tctgaatggc aaagggcttc ctgcaccgcc   1500

cactctggaa aagaaacctg aagacaattc caataatagg aaatttttaa ataagagatt   1560

atcagaaaga gagtttgatc ctgacatcca ctgtggggtt attgatctcg acaccaagaa   1620

gccctgcacc cggtctttga catgcaagac acattcctta acccagcgca gggctgtcca   1680

gggtagaaga aaacgatttg atgtgttatt agccgagcac aaaaacaaaa ccagggaaaa   1740

ggaattgatt cgccatccgg actctcagca accaccgcag cctctcaggg acccgcatcc   1800

cgcccctcct agaacgtcac aggagccgca ccaaaaccct cacggagtga ttccttccga   1860

atcaaagcct tttgtagcta gtaaacctaa acctcacacc cccagtcttc caaggcctcc   1920

aggctgccct gctcagcaag gtgggagtgc ccccattgac cctcctccag tccatgaatc   1980

tccacaccct cccctgcctg ccactgagcc agcttctcgg ttatccagtg aggagggcga   2040

aggcgatgac aaagaagagt ctgttgaaaa actggactgt cattattcag gtcatcatcc   2100

tcagccagca tctttttgca catttgggag ccggcagata ggaagaggct attacgtgtt   2160

tgactccagg tggaatcgac ttcgctgcgc cctcaacctc atggtggaga agcatctgaa   2220

tgcacagcta tggaagaaaa tcccaccagt gcccagtacc acctcaccca tctccacacg   2280

tattcctcac cggacaaact ctgtgccgac atcacaatgt ggagtcagct atctggcagc   2340

agccaccgtc tctacatccc cagtcctgct ctcatctacc tgcatctccc caaatagcaa   2400

atcggtacca gctcatggaa ccacactaaa tgcacagcct gctgcttcag gggcgatgga   2460

tcctgtgtgc agtatgcaat ccagacaagt gtcctcttca tcctcatccc cttccacgcc   2520

ctctggcctt tcctcggttc cttcctcccc catgtccagg aaacctcaga aattgaaatc   2580

cagcaaatct ttgaggccca aggagtcttc tggtaacagc actaactgtc aaaatgccag   2640

tagcagtacc agtggcggct caggaaagaa acgcaaaaac agttccccac tgttggttca   2700

ctcttcctcc tcctcttcct cctcctcctc ttcttctcat tccatggagt cttttaggaa   2760

aaactgtgtg gctcactctg ggcctcccta cccctcaacg gtaacatctt cccatagcat   2820

cggcctcaac tgtgtgacga ataaagcaaa tgcggtgaac gtccggcatg accagtcagg   2880

gaggggcccc cccaccggga gccctgctga atccatcaag aggatgagtg tgatggtgaa   2940

cagcagtgat tctactcttt ctcttgggcc attcattcac cagtccaatg aactgcctgt   3000

caactcccac ggcagttttt cccactcaca cactcctcta gacaaactca taggaaagaa   3060

aagaaagtgc tcacccagct cgagcagcat caacaacagc agcagcaaac ccacaaaggt   3120

tgccaaagtg ccagccgtga acaatgtcca catgaaacac acaggcacca tcccaggggc   3180

acaaggactg atgaacagtt ccctccttca tcaggtagga aatggactgt gagccccatg   3240

ggaatgccca tttcttctcc cttaagatct tttgtcagct cagaaatgtg tttggttggg   3300

ttggttggtt ggtttgtaaa cagatattca gcttcatggt gtcttcttaa aaaaaaaaaa   3360

aaaaaaaaaa aaggttcacg gccgtatgaa ggtaaaacag gctcttctgc cagaatttct   3420

ggtgcctttg gaagatgttc ttcagtaaag aaactacagt aatgcatttt tagtagagct   3480

gcagaaagca tcggttgtga cagcaaaatc ata                                3513


<210>  9579
<211>  892
<212>  PRT
<213>  Homosapiens

<400>  9579

Met Ser Glu Arg Ala Ala Asp Asp Val Arg Gly Glu Pro Arg Arg Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Arg Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Gln Pro Gln Arg Gln 
        35                  40                  45              


Gln His Pro Pro Pro Pro Pro Arg Arg Thr Arg Pro Glu Asp Gly Gly 
    50                  55                  60                  


Pro Gly Ala Ala Ser Thr Ser Ala Ala Ala Met Ala Thr Val Gly Glu 
65                  70                  75                  80  


Arg Arg Pro Leu Pro Ser Pro Glu Val Met Leu Gly Gln Ser Trp Asn 
                85                  90                  95      


Leu Trp Val Glu Ala Ser Lys Leu Pro Gly Lys Asp Gly Thr Glu Leu 
            100                 105                 110         


Asp Glu Ser Phe Lys Glu Phe Gly Lys Asn Arg Glu Val Met Gly Leu 
        115                 120                 125             


Cys Arg Glu Asp Met Pro Ile Phe Gly Phe Cys Pro Ala His Asp Asp 
    130                 135                 140                 


Phe Tyr Leu Val Val Cys Asn Asp Cys Asn Gln Val Val Lys Pro Gln 
145                 150                 155                 160 


Ala Phe Gln Ser His Tyr Glu Arg Arg His Ser Ser Ser Ser Lys Pro 
                165                 170                 175     


Pro Leu Ala Val Pro Pro Thr Ser Val Phe Ser Phe Phe Pro Ser Leu 
            180                 185                 190         


Ser Lys Ser Lys Gly Gly Ser Ala Ser Gly Ser Asn Arg Ser Ser Ser 
        195                 200                 205             


Gly Gly Val Leu Ser Ala Ser Ser Ser Ser Ser Lys Leu Leu Lys Ser 
    210                 215                 220                 


Pro Lys Glu Lys Leu Gln Leu Arg Gly Asn Thr Arg Pro Met His Pro 
225                 230                 235                 240 


Ile Gln Gln Ser Arg Val Pro His Gly Arg Ile Met Thr Pro Ser Val 
                245                 250                 255     


Lys Val Glu Lys Ile His Pro Lys Met Asp Gly Thr Leu Leu Lys Ser 
            260                 265                 270         


Ala Val Gly Pro Thr Cys Pro Ala Thr Val Ser Ser Leu Val Lys Pro 
        275                 280                 285             


Gly Leu Asn Cys Pro Ser Ile Pro Lys Pro Thr Leu Pro Ser Pro Gly 
    290                 295                 300                 


Gln Ile Leu Asn Gly Lys Gly Leu Pro Ala Pro Pro Thr Leu Glu Lys 
305                 310                 315                 320 


Lys Pro Glu Asp Asn Ser Asn Asn Arg Lys Phe Leu Asn Lys Arg Leu 
                325                 330                 335     


Ser Glu Arg Glu Phe Asp Pro Asp Ile His Cys Gly Val Ile Asp Leu 
            340                 345                 350         


Asp Thr Lys Lys Pro Cys Thr Arg Ser Leu Thr Cys Lys Thr His Ser 
        355                 360                 365             


Leu Thr Gln Arg Arg Ala Val Gln Gly Arg Arg Lys Arg Phe Asp Val 
    370                 375                 380                 


Leu Leu Ala Glu His Lys Asn Lys Thr Arg Glu Lys Glu Leu Ile Arg 
385                 390                 395                 400 


His Pro Asp Ser Gln Gln Pro Pro Gln Pro Leu Arg Asp Pro His Pro 
                405                 410                 415     


Ala Pro Pro Arg Thr Ser Gln Glu Pro His Gln Asn Pro His Gly Val 
            420                 425                 430         


Ile Pro Ser Glu Ser Lys Pro Phe Val Ala Ser Lys Pro Lys Pro His 
        435                 440                 445             


Thr Pro Ser Leu Pro Arg Pro Pro Gly Cys Pro Ala Gln Gln Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ile Asp Pro Pro Pro Val His Glu Ser Pro His Pro Pro 
465                 470                 475                 480 


Leu Pro Ala Thr Glu Pro Ala Ser Arg Leu Ser Ser Glu Glu Gly Glu 
                485                 490                 495     


Gly Asp Asp Lys Glu Glu Ser Val Glu Lys Leu Asp Cys His Tyr Ser 
            500                 505                 510         


Gly His His Pro Gln Pro Ala Ser Phe Cys Thr Phe Gly Ser Arg Gln 
        515                 520                 525             


Ile Gly Arg Gly Tyr Tyr Val Phe Asp Ser Arg Trp Asn Arg Leu Arg 
    530                 535                 540                 


Cys Ala Leu Asn Leu Met Val Glu Lys His Leu Asn Ala Gln Leu Trp 
545                 550                 555                 560 


Lys Lys Ile Pro Pro Val Pro Ser Thr Thr Ser Pro Ile Ser Thr Arg 
                565                 570                 575     


Ile Pro His Arg Thr Asn Ser Val Pro Thr Ser Gln Cys Gly Val Ser 
            580                 585                 590         


Tyr Leu Ala Ala Ala Thr Val Ser Thr Ser Pro Val Leu Leu Ser Ser 
        595                 600                 605             


Thr Cys Ile Ser Pro Asn Ser Lys Ser Val Pro Ala His Gly Thr Thr 
    610                 615                 620                 


Leu Asn Ala Gln Pro Ala Ala Ser Gly Ala Met Asp Pro Val Cys Ser 
625                 630                 635                 640 


Met Gln Ser Arg Gln Val Ser Ser Ser Ser Ser Ser Pro Ser Thr Pro 
                645                 650                 655     


Ser Gly Leu Ser Ser Val Pro Ser Ser Pro Met Ser Arg Lys Pro Gln 
            660                 665                 670         


Lys Leu Lys Ser Ser Lys Ser Leu Arg Pro Lys Glu Ser Ser Gly Asn 
        675                 680                 685             


Ser Thr Asn Cys Gln Asn Ala Ser Ser Ser Thr Ser Gly Gly Ser Gly 
    690                 695                 700                 


Lys Lys Arg Lys Asn Ser Ser Pro Leu Leu Val His Ser Ser Ser Ser 
705                 710                 715                 720 


Ser Ser Ser Ser Ser Ser Ser Ser His Ser Met Glu Ser Phe Arg Lys 
                725                 730                 735     


Asn Cys Val Ala His Ser Gly Pro Pro Tyr Pro Ser Thr Val Thr Ser 
            740                 745                 750         


Ser His Ser Ile Gly Leu Asn Cys Val Thr Asn Lys Ala Asn Ala Val 
        755                 760                 765             


Asn Val Arg His Asp Gln Ser Gly Arg Gly Pro Pro Thr Gly Ser Pro 
    770                 775                 780                 


Ala Glu Ser Ile Lys Arg Met Ser Val Met Val Asn Ser Ser Asp Ser 
785                 790                 795                 800 


Thr Leu Ser Leu Gly Pro Phe Ile His Gln Ser Asn Glu Leu Pro Val 
                805                 810                 815     


Asn Ser His Gly Ser Phe Ser His Ser His Thr Pro Leu Asp Lys Leu 
            820                 825                 830         


Ile Gly Lys Lys Arg Lys Cys Ser Pro Ser Ser Ser Ser Ile Asn Asn 
        835                 840                 845             


Ser Ser Ser Lys Pro Thr Lys Val Ala Lys Val Pro Ala Val Asn Asn 
    850                 855                 860                 


Val His Met Lys His Thr Gly Thr Ile Pro Gly Ala Gln Gly Leu Met 
865                 870                 875                 880 


Asn Ser Ser Leu Leu His Gln Val Gly Asn Gly Leu 
                885                 890         


<210>  9580
<211>  7393
<212>  DNA
<213>  Homosapiens

<400>  9580
aaagggtgaa agagaaactt ggcgacctcc cggaggagtt cgcgaagcga ccaggagcgt     60

gttgccatcg tcctcacccg gcacccaatt ccaccacaga gtcgggattt cgtcggtgat    120

cgtgatgggg tgcttttatt tttctctttg attttcaaaa aatgtctatg tgactgtccc    180

tatcttaagg ggaagttgaa agtgggggcg ggggtgctca atgagaaacg ttgccttgtg    240

tgtagttgtt tggagcacac tgcaaattat attggcatct ctttccaaaa gtcactttga    300

ttcaacttcg atagctttct cgtaaatggc acgtttaggt ggtgagaggt ggatgaggaa    360

acaggcacca gtgcagctga tttgacctcc agtgggatag atacgattag caccaggatc    420

gtgtctcatt ttgaacccag atctgaacag aattaagacg aacgagcttt cacaattgca    480

gcagatgaag atccattggt aaattgatca ggatttttgg cctaccctcc aaagaaaagg    540

agcggaaaga atgtcggagc gggccgcgga tgacgtcagg ggggagccgc gccgcgcggc    600

ggcggcggcg ggcggagcag cggccgcggc cgcccggcag cagcagcagc agcagcagca    660

gcagcagccg ccgcctccgc agccccagcg gcagcagcac ccgccaccgc cgccacggcg    720

cacacggccg gaggacggcg ggcccggcgc cgcctccacc tcggccgccg caatggcgac    780

ggtcggggag cgcaggcctc tgcccagtcc tgaagtgatg ctgggacagt cgtggaatct    840

gtgggttgag gcttccaaac ttcctgggaa ggacgggaca gaattggacg aaagtttcaa    900

ggagtttggg aaaaaccgcg aagtcatggg gctctgtcgg gaagacatgc caatatttgg    960

tttctgtcca gcccatgatg atttctactt ggtggtgtgt aacgactgta atcaggttgt   1020

caaaccgcag gcatttcaat cacattatga aagaagacat agctcatcca gcaagccgcc   1080

tttggccgtt cctcccactt cagtattttc cttcttccct tctctgtcca aaagcaaagg   1140

aggcagtgca agtggaagca accgttcttc cagtggaggt gttcttagcg catcctcatc   1200

aagttccaag ttgttgaaat cacccaaaga gaaactgcag ctcaggggga acaccaggcc   1260

aatgcatccc attcagcaaa gtagagttcc ccatggtaga atcatgacac cctctgtgaa   1320

agtggaaaag attcatccga aaatggatgg cacactactg aaatctgcgg tggggccaac   1380

ctgtcctgct actgtgagtt ccttagtcaa gcctggcctt aactgcccct caataccaaa   1440

gccaaccttg ccttcacctg gacagattct gaatggcaaa gggcttcctg caccgcccac   1500

tctggaaaag aaacctgaag acaattccaa taataggaaa tttttaaata agagattatc   1560

agaaagagag tttgatcctg acatccactg tggggttatt gatctcgaca ccaagaagcc   1620

ctgcacccgg tctttgacat gcaagacaca ttccttaacc cagcgcaggg ctgtccaggg   1680

tagaagaaaa cgatttgatg tgttattagc cgagcacaaa aacaaaacca gggaaaagga   1740

attgattcgc catccggact ctcagcaacc accgcagcct ctcagggacc cgcatcccgc   1800

ccctcctaga acgtcacagg agccgcacca aaaccctcac ggagtgattc cttccgaatc   1860

aaagcctttt gtagctagta aacctaaacc tcacaccccc agtcttccaa ggcctccagg   1920

ctgccctgct cagcaaggtg ggagtgcccc cattgaccct cctccagtcc atgaatctcc   1980

acaccctccc ctgcctgcca ctgagccagc ttctcggtta tccagtgagg agggcgaagg   2040

cgatgacaaa gaagagtctg ttgaaaaact ggactgtcat tattcaggtc atcatcctca   2100

gccagcatct ttttgcacat ttgggagccg gcagatagga agaggctatt acgtgtttga   2160

ctccaggtgg aatcgacttc gctgcgccct caacctcatg gtggagaagc atctgaatgc   2220

acagctatgg aagaaaatcc caccagtgcc cagtaccacc tcacccatct ccacacgtat   2280

tcctcaccgg acaaactctg tgccgacatc acaatgtgga gtcagctatc tggcagcagc   2340

caccgtctct acatccccag tcctgctctc atctacctgc atctccccaa atagcaaatc   2400

ggtaccagct catggaacca cactaaatgc acagcctgct gcttcagggg cgatggatcc   2460

tgtgtgcagt atgcaatcca gacaagtgtc ctcttcatcc tcatcccctt ccacgccctc   2520

tggcctttcc tcggttcctt cctcccccat gtccaggaaa cctcagaaat tgaaatccag   2580

caaatctttg aggcccaagg agtcttctgg taacagcact aactgtcaaa atgccagtag   2640

cagtaccagt ggcggctcag gaaagaaacg caaaaacagt tccccactgt tggttcactc   2700

ttcctcctcc tcttcctcct cctcctcttc ttctcattcc atggagtctt ttaggaaaaa   2760

ctgtgtggct cactctgggc ctccctaccc ctcaacggta acatcttccc atagcatcgg   2820

cctcaactgt gtgacgaata aagcaaatgc ggtgaacgtc cggcatgacc agtcagggag   2880

gggccccccc accgggagcc ctgctgaatc catcaagagg atgagtgtga tggtgaacag   2940

cagtgattct actctttctc ttgggccatt cattcaccag tccaatgaac tgcctgtcaa   3000

ctcccacggc agtttttccc actcacacac tcctctagac aaactcatag gaaagaaaag   3060

aaagtgctca cccagctcga gcagcatcaa caacagcagc agcaaaccca caaaggttgc   3120

caaagtgcca gccgtgaaca atgtccacat gaaacacaca ggcaccatcc caggggcaca   3180

aggactgatg aacagttccc tccttcatca gccaaaggca cgtccctgac agctgaaaat   3240

agcacgggga ggaataatgc ggacactttt gaggacaagt tacacctcca ctcagcactc   3300

tggactccac gatgcctttg agtctgtttt cccaacctcc tgtgggcctc aagggtagaa   3360

acctgccggg ctgttgtttt aacgaggatt tccctgaagc tatgtctcta gcagtgagta   3420

ctcataaagg acactggatc aagttcagcc accgaattgc ttttatcagt gttaaagtgg   3480

tctgaactgc ttgctaccaa tctgtgagaa gtttttgttt ttgttttgtt ttttaacttg   3540

cagtatatca cagagccact cttcaagtag attggctggg caaaagaatg ttttggcaag   3600

agcgttactg tagacctttc tccctccttc cttttactac catttttttt taacactgtc   3660

atctgtaggt cactctccag cagttaggca ccttaactgg agaccagaaa ccttccagag   3720

aacacagggc tgcatcccga gcaaccctct gaagaaggga attaggcttt agattttgat   3780

agcaatgttc caggaatgaa atatagatgt tagcccaaga caccatgaca aaatagccca   3840

gccttttgag agtaatttgg gaaaagaagc tgtcagaagt ttctaactta caaactggtt   3900

tgaaattttt gatgcccaga cagcaagtat aaatcatttt ggaggcttac ttttcatgat   3960

acaaaagcaa ttctgtgtga tttttttttt taagaagaaa gaaaatgcaa gctagttttg   4020

agaaaggaag gccaaattgg gtcgggggag ggtgggagtg aggaagttaa aatcactata   4080

gggagaaaaa acttttttca agatttccaa agagatgaaa ttttcttaat ccttttaagt   4140

tttcatagta aacagtatgg cagattgggt tggttgtcct acctggtcta tttttaaaag   4200

tcacctttta aagtgacatt attagataca cttaaatgtt tccaaggcac tctctacatt   4260

acccttgttt ttctctttgg atactgtcct gggactaagt gtagatttct gcttcaagca   4320

cttctggcat tgtgtgtttt tgtatgcact ccccttcatg ccacttcaga tgtttatttg   4380

gatgtggttg gggacgagag cagacaccaa ggaaagggag ttggagagaa tgtaagtcct   4440

gacctgaagg tcttttgtga tgcatgtata ggattgccct gacacacacc ctcctttctt   4500

gggattatac cagccatctt cctgagagtt ttggagccct ctaggatatt ttttctagta   4560

ccccaccccc cacccctaaa gaaagacctt aatatgttaa aacagcattg cttggagaag   4620

gtgtcattga attccgggac gagccggagc ctttaaatgg gtgcttccac cactacaggc   4680

tcctgacacg agtaacaggc actgttgctt agaagaacac acgaagttgc cgaacacagg   4740

gtaaaatttc caaggcgctg atcgttgccc tggccagggc ctgatgagag ccagtcagta   4800

cattcttttt ttcctacagt tcttgggttt caaacttcag tttcagggaa tttcaagtca   4860

acaacaggta gaatgaataa acttggttac cagcctaata atgtgaattg ctacagaatt   4920

attcttatta tgtaagaaaa caaaaacttt atgcagatac tttagctata aattgatgta   4980

aaatactgat ttttttaaag gaaggagaga acagtatctt gttcaattat tatgcaatca   5040

atcagtaaat gtttttaaaa tgatactaca ggagagctta gtaaggagag ggcatggatg   5100

ggccagtttg gcatagttgg gagaaatcag tctggtttcc atcccagtcg gggaagagag   5160

aggtgagagg gaatcagaac gtacctagtt gattccttgg tgacaagtgc aatggggtat   5220

gggtagaatt tattttcaga gccaagagga cttgatggtt ataaataaag ttgcctttag   5280

caatggaatt tacagatcga tcatgttgtt ccgaaagatg tgaataggat ccacaataac   5340

aagttgattc agactaatgt agatatttag attagcaagt attgaacatt tgatttctta   5400

gactgaggtt ttaaatgaat ttcattattt ctcccggtaa tacacagagc atcgggatta   5460

ggaaattagc cattttggat tctgtctgcc acaaacagac ctattctaaa cagtgctatt   5520

aaattttaga ctgttgttca aatattttat tttctcctaa actacttttt atggtgatga   5580

ataattaaga ccatttaaaa cacgggagta caagtatttt tttgaattaa attaacttgc   5640

aaaaaccaaa tttgcagtgg ttgggttgtt tctagacaga ctttggtatc aatttaaaac   5700

caagataatt tttatattct ttccaataga atttcatgac aactcctgca gttttcttaa   5760

cctacaaaaa aaaaaaaaaa gtgctgcaat gatgaacaaa gaattataca aaacctactt   5820

ttgtatcttt attttggaat ttcttgttct attataaata tggaagtatc cctatttcag   5880

aagacatatt ttgttaaaaa tgaattgtac atatttaaat atgtattttt gcacaggtct   5940

ttttttctga tatcctgttt tggtacaatt gagatcatct agtatttatt tattaattaa   6000

taaaagtaaa taccttttta taatttgaag tggttcactg ccaagccaat agttctagaa   6060

cctgcctcct ttacagtttt aagggatgcc tctgttctgt gaaaagtctt tgtccctttt   6120

agtgtctcgg gagtggattc atacagatga agtgggcatt gcttcttcct ggttgcctgg   6180

tttcccgata gactacatgt aactaagtga cacactgctt ttcttttgtt agtattttat   6240

gtgtgggagt atgtgactgc gtgtgtgtgt gcctgtgcgt gtgtgtgtat actcagcaca   6300

tgtatgttac tatgtgatgt ggtttaaaac taatggaaaa aactgaaagt gcctgaaact   6360

agttttaagc ttagacagaa tctctttaaa aagacttgaa tgttcagttg aacttttgga   6420

gtttgctttt tccacctaaa tattgtttct aaaattttag gggcggagtt gaaaaccacc   6480

aatgctggta attttataag gtattttaaa attaagacct cttggttcat agtaattcaa   6540

ttggtgatgg attgcctggt ggcaccaagg gttacagatc tttttgtcag ccagcaactt   6600

acacgatgtg tccgttttgt tattcactca tgaaatacaa tttaaaatat ttaaaatatt   6660

ttgtattcca aaaatataat acaaagaagt acctctgaga acattgaaaa aaatgtataa   6720

tttgaaaaat gtaacttata agggcagctg tcttcctgca agagttctgt tgccaaggaa   6780

tttcttaatg tcgctcattc tgtccagggg gtttggggcg attgggcttt gaaaaaatat   6840

tcttaaaagt ttgtttagca gaaaataatc acttttacat tttgtgcaaa acattttaca   6900

ttttcagata atttaaatga gcactacata ctgtcagtgt gaatgtaggg ccttgaaagc   6960

attttgcttt tttttttttt tttttttttt tgagcttggt tataaaagca atctcctgtg   7020

ttaaaaacgt gtgaatagtt tgataatttg tacacataat caagagcatc tcagctggac   7080

tttgtgttgg ctgctgtata gaacatgaac aaatgtcaag ggatagaaaa ttactttgga   7140

tatttaaaag agaagaaata tatagtctat ttgttttgta acaagtttct gtaaataaaa   7200

taatttatac tatttataag aaaaggttgt gctttgcttt ataagaaatt agcttgtgga   7260

acaaacatgt tactaaacgg gcaataaaat taggacttct caataaataa ggttggctgc   7320

atgaaatatt gtacgtttct gcctcgttgt gatactaaac cctttcagtc tactctgact   7380

tttcatcact ttt                                                      7393


<210>  9581
<211>  892
<212>  PRT
<213>  Homosapiens

<400>  9581

Met Ser Glu Arg Ala Ala Asp Asp Val Arg Gly Glu Pro Arg Arg Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Arg Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Gln Pro Gln Arg Gln 
        35                  40                  45              


Gln His Pro Pro Pro Pro Pro Arg Arg Thr Arg Pro Glu Asp Gly Gly 
    50                  55                  60                  


Pro Gly Ala Ala Ser Thr Ser Ala Ala Ala Met Ala Thr Val Gly Glu 
65                  70                  75                  80  


Arg Arg Pro Leu Pro Ser Pro Glu Val Met Leu Gly Gln Ser Trp Asn 
                85                  90                  95      


Leu Trp Val Glu Ala Ser Lys Leu Pro Gly Lys Asp Gly Thr Glu Leu 
            100                 105                 110         


Asp Glu Ser Phe Lys Glu Phe Gly Lys Asn Arg Glu Val Met Gly Leu 
        115                 120                 125             


Cys Arg Glu Asp Met Pro Ile Phe Gly Phe Cys Pro Ala His Asp Asp 
    130                 135                 140                 


Phe Tyr Leu Val Val Cys Asn Asp Cys Asn Gln Val Val Lys Pro Gln 
145                 150                 155                 160 


Ala Phe Gln Ser His Tyr Glu Arg Arg His Ser Ser Ser Ser Lys Pro 
                165                 170                 175     


Pro Leu Ala Val Pro Pro Thr Ser Val Phe Ser Phe Phe Pro Ser Leu 
            180                 185                 190         


Ser Lys Ser Lys Gly Gly Ser Ala Ser Gly Ser Asn Arg Ser Ser Ser 
        195                 200                 205             


Gly Gly Val Leu Ser Ala Ser Ser Ser Ser Ser Lys Leu Leu Lys Ser 
    210                 215                 220                 


Pro Lys Glu Lys Leu Gln Leu Arg Gly Asn Thr Arg Pro Met His Pro 
225                 230                 235                 240 


Ile Gln Gln Ser Arg Val Pro His Gly Arg Ile Met Thr Pro Ser Val 
                245                 250                 255     


Lys Val Glu Lys Ile His Pro Lys Met Asp Gly Thr Leu Leu Lys Ser 
            260                 265                 270         


Ala Val Gly Pro Thr Cys Pro Ala Thr Val Ser Ser Leu Val Lys Pro 
        275                 280                 285             


Gly Leu Asn Cys Pro Ser Ile Pro Lys Pro Thr Leu Pro Ser Pro Gly 
    290                 295                 300                 


Gln Ile Leu Asn Gly Lys Gly Leu Pro Ala Pro Pro Thr Leu Glu Lys 
305                 310                 315                 320 


Lys Pro Glu Asp Asn Ser Asn Asn Arg Lys Phe Leu Asn Lys Arg Leu 
                325                 330                 335     


Ser Glu Arg Glu Phe Asp Pro Asp Ile His Cys Gly Val Ile Asp Leu 
            340                 345                 350         


Asp Thr Lys Lys Pro Cys Thr Arg Ser Leu Thr Cys Lys Thr His Ser 
        355                 360                 365             


Leu Thr Gln Arg Arg Ala Val Gln Gly Arg Arg Lys Arg Phe Asp Val 
    370                 375                 380                 


Leu Leu Ala Glu His Lys Asn Lys Thr Arg Glu Lys Glu Leu Ile Arg 
385                 390                 395                 400 


His Pro Asp Ser Gln Gln Pro Pro Gln Pro Leu Arg Asp Pro His Pro 
                405                 410                 415     


Ala Pro Pro Arg Thr Ser Gln Glu Pro His Gln Asn Pro His Gly Val 
            420                 425                 430         


Ile Pro Ser Glu Ser Lys Pro Phe Val Ala Ser Lys Pro Lys Pro His 
        435                 440                 445             


Thr Pro Ser Leu Pro Arg Pro Pro Gly Cys Pro Ala Gln Gln Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ile Asp Pro Pro Pro Val His Glu Ser Pro His Pro Pro 
465                 470                 475                 480 


Leu Pro Ala Thr Glu Pro Ala Ser Arg Leu Ser Ser Glu Glu Gly Glu 
                485                 490                 495     


Gly Asp Asp Lys Glu Glu Ser Val Glu Lys Leu Asp Cys His Tyr Ser 
            500                 505                 510         


Gly His His Pro Gln Pro Ala Ser Phe Cys Thr Phe Gly Ser Arg Gln 
        515                 520                 525             


Ile Gly Arg Gly Tyr Tyr Val Phe Asp Ser Arg Trp Asn Arg Leu Arg 
    530                 535                 540                 


Cys Ala Leu Asn Leu Met Val Glu Lys His Leu Asn Ala Gln Leu Trp 
545                 550                 555                 560 


Lys Lys Ile Pro Pro Val Pro Ser Thr Thr Ser Pro Ile Ser Thr Arg 
                565                 570                 575     


Ile Pro His Arg Thr Asn Ser Val Pro Thr Ser Gln Cys Gly Val Ser 
            580                 585                 590         


Tyr Leu Ala Ala Ala Thr Val Ser Thr Ser Pro Val Leu Leu Ser Ser 
        595                 600                 605             


Thr Cys Ile Ser Pro Asn Ser Lys Ser Val Pro Ala His Gly Thr Thr 
    610                 615                 620                 


Leu Asn Ala Gln Pro Ala Ala Ser Gly Ala Met Asp Pro Val Cys Ser 
625                 630                 635                 640 


Met Gln Ser Arg Gln Val Ser Ser Ser Ser Ser Ser Pro Ser Thr Pro 
                645                 650                 655     


Ser Gly Leu Ser Ser Val Pro Ser Ser Pro Met Ser Arg Lys Pro Gln 
            660                 665                 670         


Lys Leu Lys Ser Ser Lys Ser Leu Arg Pro Lys Glu Ser Ser Gly Asn 
        675                 680                 685             


Ser Thr Asn Cys Gln Asn Ala Ser Ser Ser Thr Ser Gly Gly Ser Gly 
    690                 695                 700                 


Lys Lys Arg Lys Asn Ser Ser Pro Leu Leu Val His Ser Ser Ser Ser 
705                 710                 715                 720 


Ser Ser Ser Ser Ser Ser Ser Ser His Ser Met Glu Ser Phe Arg Lys 
                725                 730                 735     


Asn Cys Val Ala His Ser Gly Pro Pro Tyr Pro Ser Thr Val Thr Ser 
            740                 745                 750         


Ser His Ser Ile Gly Leu Asn Cys Val Thr Asn Lys Ala Asn Ala Val 
        755                 760                 765             


Asn Val Arg His Asp Gln Ser Gly Arg Gly Pro Pro Thr Gly Ser Pro 
    770                 775                 780                 


Ala Glu Ser Ile Lys Arg Met Ser Val Met Val Asn Ser Ser Asp Ser 
785                 790                 795                 800 


Thr Leu Ser Leu Gly Pro Phe Ile His Gln Ser Asn Glu Leu Pro Val 
                805                 810                 815     


Asn Ser His Gly Ser Phe Ser His Ser His Thr Pro Leu Asp Lys Leu 
            820                 825                 830         


Ile Gly Lys Lys Arg Lys Cys Ser Pro Ser Ser Ser Ser Ile Asn Asn 
        835                 840                 845             


Ser Ser Ser Lys Pro Thr Lys Val Ala Lys Val Pro Ala Val Asn Asn 
    850                 855                 860                 


Val His Met Lys His Thr Gly Thr Ile Pro Gly Ala Gln Gly Leu Met 
865                 870                 875                 880 


Asn Ser Ser Leu Leu His Gln Pro Lys Ala Arg Pro 
                885                 890         


<210>  9582
<211>  1698
<212>  DNA
<213>  Homosapiens

<400>  9582
gcgcgccagg gatcttggca tgcccgtatg tgtgggacgc ggtcaaggtg tgagagaagt     60

tcaaaacagg gtgccccaga ggcagcacac actctgtacg ggggacatct cgtgcttttt    120

tccctttctc ttccatgacg ctcagggcta ggcattgtca ctctcatgct tcacagcctc    180

cggtactcag aggcagttct gtctttcctg attagctcct ttcctgaagg atctagaacc    240

ctgactgggc atgccagtgt gggagtcagc aagcacgcgg ctatgttttc tcttgcagtt    300

ttgcacattt gggagccggc agataggaag aggctattac gtgtttgact ccaggtggaa    360

tcgacttcgc tgcgccctca acctcatggt ggagaagcat ctgaatgcac agctatggaa    420

gaaaatccca ccagtgccca gtaccacctc acccatctcc acacgtattc ctcaccggac    480

aaactctgtg ccgacatcac aatgtggagt cagctatctg gcagcagcca ccgtctctac    540

atccccagtc ctgctctcat ctacctgcat ctccccaaat agcaaatcgg taccagctca    600

tggaaccaca ctaaatgcac agcctgctgc ttcaggggcg atggatcctg tgtgcagtat    660

gcaatccaga caagtgtcct cttcatcctc atccccttcc acgccctctg gcctttcctc    720

ggttccttcc tcccccatgt ccaggaaacc tcagaaattg aaatccagca aatctttgag    780

gcccaaggag tcttctggta acagcactaa ctgtcaaaat gccagtagca gtaccagtgg    840

cggctcagga aagaaacgca aaaacagttc cccactgttg gttcactctt cctcctcctc    900

ttcctcctcc tcctcttctt ctcattccat ggagtctttt aggaaaaact gtgtggctca    960

ctctgggcct ccctacccct caacggtaac atcttcccat agcatcggcc tcaactgtgt   1020

gacgaataaa gcaaatgcgg tgaacgtccg gcatgaccag tcagggaggg gcccccccac   1080

cgggagccct gctgaatcca tcaagaggat gagtgtgatg gtgaacagca gtgattctac   1140

tctttctctt gggccattca ttcaccagtc caatgaactg cctgtcaact cccacggcag   1200

tttttcccac tcacacactc ctctagacaa actcatagga aagaaaagaa agtgctcacc   1260

cagctcgagc agcatcaaca acagcagcag caaacccaca aaggttgcca aagtgccagc   1320

cgtgaacaat gtccacatga aacacacagg caccatccca ggggcacaag gactgatgaa   1380

cagttccctc cttcatcagg taggaaatgg actgtgagcc ccatgggaat gcccatttct   1440

tctcccttaa gatcttttgt cagctcagaa atgtgtttgg ttgggttggt tggttggttt   1500

gtaaacagat attcagcttc atggtgtctt cttaaaaaaa aaaaaaaaaa aaaaaaaggt   1560

tcacggccgt atgaaggtaa aacaggctct tctgccagaa tttctggtgc ctttggaaga   1620

tgttcttcag taaagaaact acagtaatgc atttttagta gagctgcaga aagcatcggt   1680

tgtgacagca aaatcata                                                 1698


<210>  9583
<211>  388
<212>  PRT
<213>  Homosapiens

<400>  9583

Met Pro Val Trp Glu Ser Ala Ser Thr Arg Leu Cys Phe Leu Leu Gln 
1               5                   10                  15      


Phe Cys Thr Phe Gly Ser Arg Gln Ile Gly Arg Gly Tyr Tyr Val Phe 
            20                  25                  30          


Asp Ser Arg Trp Asn Arg Leu Arg Cys Ala Leu Asn Leu Met Val Glu 
        35                  40                  45              


Lys His Leu Asn Ala Gln Leu Trp Lys Lys Ile Pro Pro Val Pro Ser 
    50                  55                  60                  


Thr Thr Ser Pro Ile Ser Thr Arg Ile Pro His Arg Thr Asn Ser Val 
65                  70                  75                  80  


Pro Thr Ser Gln Cys Gly Val Ser Tyr Leu Ala Ala Ala Thr Val Ser 
                85                  90                  95      


Thr Ser Pro Val Leu Leu Ser Ser Thr Cys Ile Ser Pro Asn Ser Lys 
            100                 105                 110         


Ser Val Pro Ala His Gly Thr Thr Leu Asn Ala Gln Pro Ala Ala Ser 
        115                 120                 125             


Gly Ala Met Asp Pro Val Cys Ser Met Gln Ser Arg Gln Val Ser Ser 
    130                 135                 140                 


Ser Ser Ser Ser Pro Ser Thr Pro Ser Gly Leu Ser Ser Val Pro Ser 
145                 150                 155                 160 


Ser Pro Met Ser Arg Lys Pro Gln Lys Leu Lys Ser Ser Lys Ser Leu 
                165                 170                 175     


Arg Pro Lys Glu Ser Ser Gly Asn Ser Thr Asn Cys Gln Asn Ala Ser 
            180                 185                 190         


Ser Ser Thr Ser Gly Gly Ser Gly Lys Lys Arg Lys Asn Ser Ser Pro 
        195                 200                 205             


Leu Leu Val His Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
    210                 215                 220                 


His Ser Met Glu Ser Phe Arg Lys Asn Cys Val Ala His Ser Gly Pro 
225                 230                 235                 240 


Pro Tyr Pro Ser Thr Val Thr Ser Ser His Ser Ile Gly Leu Asn Cys 
                245                 250                 255     


Val Thr Asn Lys Ala Asn Ala Val Asn Val Arg His Asp Gln Ser Gly 
            260                 265                 270         


Arg Gly Pro Pro Thr Gly Ser Pro Ala Glu Ser Ile Lys Arg Met Ser 
        275                 280                 285             


Val Met Val Asn Ser Ser Asp Ser Thr Leu Ser Leu Gly Pro Phe Ile 
    290                 295                 300                 


His Gln Ser Asn Glu Leu Pro Val Asn Ser His Gly Ser Phe Ser His 
305                 310                 315                 320 


Ser His Thr Pro Leu Asp Lys Leu Ile Gly Lys Lys Arg Lys Cys Ser 
                325                 330                 335     


Pro Ser Ser Ser Ser Ile Asn Asn Ser Ser Ser Lys Pro Thr Lys Val 
            340                 345                 350         


Ala Lys Val Pro Ala Val Asn Asn Val His Met Lys His Thr Gly Thr 
        355                 360                 365             


Ile Pro Gly Ala Gln Gly Leu Met Asn Ser Ser Leu Leu His Gln Val 
    370                 375                 380                 


Gly Asn Gly Leu 
385             


<210>  9584
<211>  4777
<212>  DNA
<213>  Homosapiens

<400>  9584
ccactgttgg ttcactcttc ctcctcctct tcctcctcct cctcttcttc tcattccatg     60

gagtctttta ggaaaaactg tgtggctcac tctgggcctc cctacccctc aacggtaaca    120

tcttcccata gcatcggcct caactgtgtg acgaataaag caaatgcggt gaacgtccgg    180

catgaccagt cagggagggg cccccccacc gggagccctg ctgaatccat caagaggatg    240

agtgtgatgg tgaacagcag tgattctact ctttctcttg ggccattcat tcaccagtcc    300

aatgaactgc ctgtcaactc ccacggcagt ttttcccact cacacactcc tctagacaaa    360

ctcataggaa agaaaagaaa gtgctcaccc agctcgagca gcatcaacaa cagcagcagc    420

aaacccacaa aggttgccaa agtgccagcc gtgaacaatg tccacatgaa acacacaggc    480

accatcccag gggcacaagg actgatgaac agttccctcc ttcatcagga tatctcctca    540

ccttgcttac gaacaggaat ttcagcaaca tcaccccaga gccctgactt aaaatccaaa    600

ggcacgtccc tgacagctga aaatagcacg gggaggaata atgcggacac ttttgaggac    660

aagttacacc tccactcagc actctggact ccacgatgcc tttgagtctg ttttcccaac    720

ctcctgtggg cctcaagggt agaaacctgc cgggctgttg ttttaacgag gatttccctg    780

aagctatgtc tctagcagtg agtactcata aaggacactg gatcaagttc agccaccgaa    840

ttgcttttat cagtgttaaa gtggtctgaa ctgcttgcta ccaatctgtg agaagttttt    900

gtttttgttt tgttttttaa cttgcagtat atcacagagc cactcttcaa gtagattggc    960

tgggcaaaag aatgttttgg caagagcgtt actgtagacc tttctccctc cttcctttta   1020

ctaccatttt tttttaacac tgtcatctgt aggtcactct ccagcagtta ggcaccttaa   1080

ctggagacca gaaaccttcc agagaacaca gggctgcatc ccgagcaacc ctctgaagaa   1140

gggaattagg ctttagattt tgatagcaat gttccaggaa tgaaatatag atgttagccc   1200

aagacaccat gacaaaatag cccagccttt tgagagtaat ttgggaaaag aagctgtcag   1260

aagtttctaa cttacaaact ggtttgaaat ttttgatgcc cagacagcaa gtataaatca   1320

ttttggaggc ttacttttca tgatacaaaa gcaattctgt gtgatttttt tttttaagaa   1380

gaaagaaaat gcaagctagt tttgagaaag gaaggccaaa ttgggtcggg ggagggtggg   1440

agtgaggaag ttaaaatcac tatagggaga aaaaactttt ttcaagattt ccaaagagat   1500

gaaattttct taatcctttt aagttttcat agtaaacagt atggcagatt gggttggttg   1560

tcctacctgg tctattttta aaagtcacct tttaaagtga cattattaga tacacttaaa   1620

tgtttccaag gcactctcta cattaccctt gtttttctct ttggatactg tcctgggact   1680

aagtgtagat ttctgcttca agcacttctg gcattgtgtg tttttgtatg cactcccctt   1740

catgccactt cagatgttta tttggatgtg gttggggacg agagcagaca ccaaggaaag   1800

ggagttggag agaatgtaag tcctgacctg aaggtctttt gtgatgcatg tataggattg   1860

ccctgacaca caccctcctt tcttgggatt ataccagcca tcttcctgag agttttggag   1920

ccctctagga tattttttct agtaccccac cccccacccc taaagaaaga ccttaatatg   1980

ttaaaacagc attgcttgga gaaggtgtca ttgaattccg ggacgagccg gagcctttaa   2040

atgggtgctt ccaccactac aggctcctga cacgagtaac aggcactgtt gcttagaaga   2100

acacacgaag ttgccgaaca cagggtaaaa tttccaaggc gctgatcgtt gccctggcca   2160

gggcctgatg agagccagtc agtacattct ttttttccta cagttcttgg gtttcaaact   2220

tcagtttcag ggaatttcaa gtcaacaaca ggtagaatga ataaacttgg ttaccagcct   2280

aataatgtga attgctacag aattattctt attatgtaag aaaacaaaaa ctttatgcag   2340

atactttagc tataaattga tgtaaaatac tgattttttt aaaggaagga gagaacagta   2400

tcttgttcaa ttattatgca atcaatcagt aaatgttttt aaaatgatac tacaggagag   2460

cttagtaagg agagggcatg gatgggccag tttggcatag ttgggagaaa tcagtctggt   2520

ttccatccca gtcggggaag agagaggtga gagggaatca gaacgtacct agttgattcc   2580

ttggtgacaa gtgcaatggg gtatgggtag aatttatttt cagagccaag aggacttgat   2640

ggttataaat aaagttgcct ttagcaatgg aatttacaga tcgatcatgt tgttccgaaa   2700

gatgtgaata ggatccacaa taacaagttg attcagacta atgtagatat ttagattagc   2760

aagtattgaa catttgattt cttagactga ggttttaaat gaatttcatt atttctcccg   2820

gtaatacaca gagcatcggg attaggaaat tagccatttt ggattctgtc tgccacaaac   2880

agacctattc taaacagtgc tattaaattt tagactgttg ttcaaatatt ttattttctc   2940

ctaaactact ttttatggtg atgaataatt aagaccattt aaaacacggg agtacaagta   3000

tttttttgaa ttaaattaac ttgcaaaaac caaatttgca gtggttgggt tgtttctaga   3060

cagactttgg tatcaattta aaaccaagat aatttttata ttctttccaa tagaatttca   3120

tgacaactcc tgcagttttc ttaacctaca aaaaaaaaaa aaaagtgctg caatgatgaa   3180

caaagaatta tacaaaacct acttttgtat ctttattttg gaatttcttg ttctattata   3240

aatatggaag tatccctatt tcagaagaca tattttgtta aaaatgaatt gtacatattt   3300

aaatatgtat ttttgcacag gtcttttttt ctgatatcct gttttggtac aattgagatc   3360

atctagtatt tatttattaa ttaataaaag taaatacctt tttataattt gaagtggttc   3420

actgccaagc caatagttct agaacctgcc tcctttacag ttttaaggga tgcctctgtt   3480

ctgtgaaaag tctttgtccc ttttagtgtc tcgggagtgg attcatacag atgaagtggg   3540

cattgcttct tcctggttgc ctggtttccc gatagactac atgtaactaa gtgacacact   3600

gcttttcttt tgttagtatt ttatgtgtgg gagtatgtga ctgcgtgtgt gtgtgcctgt   3660

gcgtgtgtgt gtatactcag cacatgtatg ttactatgtg atgtggttta aaactaatgg   3720

aaaaaactga aagtgcctga aactagtttt aagcttagac agaatctctt taaaaagact   3780

tgaatgttca gttgaacttt tggagtttgc tttttccacc taaatattgt ttctaaaatt   3840

ttaggggcgg agttgaaaac caccaatgct ggtaatttta taaggtattt taaaattaag   3900

acctcttggt tcatagtaat tcaattggtg atggattgcc tggtggcacc aagggttaca   3960

gatctttttg tcagccagca acttacacga tgtgtccgtt ttgttattca ctcatgaaat   4020

acaatttaaa atatttaaaa tattttgtat tccaaaaata taatacaaag aagtacctct   4080

gagaacattg aaaaaaatgt ataatttgaa aaatgtaact tataagggca gctgtcttcc   4140

tgcaagagtt ctgttgccaa ggaatttctt aatgtcgctc attctgtcca gggggtttgg   4200

ggcgattggg ctttgaaaaa atattcttaa aagtttgttt agcagaaaat aatcactttt   4260

acattttgtg caaaacattt tacattttca gataatttaa atgagcacta catactgtca   4320

gtgtgaatgt agggccttga aagcattttg cttttttttt tttttttttt tttttgagct   4380

tggttataaa agcaatctcc tgtgttaaaa acgtgtgaat agtttgataa tttgtacaca   4440

taatcaagag catctcagct ggactttgtg ttggctgctg tatagaacat gaacaaatgt   4500

caagggatag aaaattactt tggatattta aaagagaaga aatatatagt ctatttgttt   4560

tgtaacaagt ttctgtaaat aaaataattt atactattta taagaaaagg ttgtgctttg   4620

ctttataaga aattagcttg tggaacaaac atgttactaa acgggcaata aaattaggac   4680

ttctcaataa ataaggttgg ctgcatgaaa tattgtacgt ttctgcctcg ttgtgatact   4740

aaaccctttc agtctactct gacttttcat cactttt                            4777


<210>  9585
<211>  215
<212>  PRT
<213>  Homosapiens

<400>  9585

Met Glu Ser Phe Arg Lys Asn Cys Val Ala His Ser Gly Pro Pro Tyr 
1               5                   10                  15      


Pro Ser Thr Val Thr Ser Ser His Ser Ile Gly Leu Asn Cys Val Thr 
            20                  25                  30          


Asn Lys Ala Asn Ala Val Asn Val Arg His Asp Gln Ser Gly Arg Gly 
        35                  40                  45              


Pro Pro Thr Gly Ser Pro Ala Glu Ser Ile Lys Arg Met Ser Val Met 
    50                  55                  60                  


Val Asn Ser Ser Asp Ser Thr Leu Ser Leu Gly Pro Phe Ile His Gln 
65                  70                  75                  80  


Ser Asn Glu Leu Pro Val Asn Ser His Gly Ser Phe Ser His Ser His 
                85                  90                  95      


Thr Pro Leu Asp Lys Leu Ile Gly Lys Lys Arg Lys Cys Ser Pro Ser 
            100                 105                 110         


Ser Ser Ser Ile Asn Asn Ser Ser Ser Lys Pro Thr Lys Val Ala Lys 
        115                 120                 125             


Val Pro Ala Val Asn Asn Val His Met Lys His Thr Gly Thr Ile Pro 
    130                 135                 140                 


Gly Ala Gln Gly Leu Met Asn Ser Ser Leu Leu His Gln Asp Ile Ser 
145                 150                 155                 160 


Ser Pro Cys Leu Arg Thr Gly Ile Ser Ala Thr Ser Pro Gln Ser Pro 
                165                 170                 175     


Asp Leu Lys Ser Lys Gly Thr Ser Leu Thr Ala Glu Asn Ser Thr Gly 
            180                 185                 190         


Arg Asn Asn Ala Asp Thr Phe Glu Asp Lys Leu His Leu His Ser Ala 
        195                 200                 205             


Leu Trp Thr Pro Arg Cys Leu 
    210                 215 


<210>  9586
<211>  2773
<212>  DNA
<213>  Homosapiens

<400>  9586
ttgtgaaaga aacgagggag ttgatggatt gagaaacaca ttctatttgt acttaggtgc     60

aaatttgatg acatgtagtt ttggtttaag ataagctttt tatccagacc cggtctaatc    120

tcttcctttc ttttacatac ctcccttact ggcaatacaa gtgcatttta gtattatttg    180

gaacacagca taatcattta cctctagaaa tccagacatt tttactgttt gcaaataaac    240

cattctgata aattattttt gttgcttaaa ataagaggag gaaccgctgt gtgttagcaa    300

gaatgtccat acctgatatg aaagagtcat gttggcttca gttcctactg ccctgtggac    360

ttcccattcc ctccttactt gagtcaacca tccactcagt actttccaca aatctaataa    420

tgaggtgctc tctgtaggta aatcctttca ctatggcttg tcctcaaacc tcccaagaaa    480

aggttcaact gctcaatctc ttaacctttt taattccatt cccttgcagg tatcccggcc    540

ctgcataaca agatgatccc aactcaagga aaggggttta gcagtgttgg atcttggcgt    600

atgtgggatt taaccaggca gaaaggcaga caagagtaag attctaggca gagagagcaa    660

atgcgtcgag catgggtatg aacatgtgag ggatagagaa taattctgca ggaagtttgc    720

tggatggaag ggccttatag ggttagaaaa gctggtgtca gattgtcaag gactttgaat    780

gtcatggggc ttctcttcca ggaacacatg ggatcaggct tagattaacc caaatgtaat    840

tgtcagagcc cagagatatt tcatggtcca gtcctagcac tgtgcagctg ccaaaagtca    900

aagccattca aatctgtact gaaaactgtg gaaaagcaaa ggagcactta agtctctttc    960

cccatgtctt gcattctcac tctcttttgc ttcaaagatc tgtctttacc tgcccctgtc   1020

cccagtccta acaaaaagca ctcccctaaa tcaactctta agttcctctc ccttctcact   1080

cctttcttag tctcctcttt ctgtaagaag ttcttgctcc tgttgttaat ggaagttaat   1140

taaagtagta tttcaccttg taaggctgta attcttggca cttgttatcc tcattttcta   1200

catccaaaga ccatggacca gaatatctct taggaggtaa gggagagtga ggctatcagc   1260

caaagaaaaa gtctccaggg ggaaggggag aatcacttat aatttaatac tttgtggaaa   1320

aaacatctct gccacctatg gccctccaat aacaatggaa gacagaatca acaggtgaga   1380

accttgggac aaaaataagt tacaaagctg ttgtaatcca ggtaagagct attaagtttc   1440

caaacgaagg ctgactgtga ggataagtga tactgatttc agaaatcttt aaaaagtaga   1500

accaacaagc cttgaggtct aactctgttc aacattaaag ggaagagtga gtctaagaag   1560

acttcaggtt tctagcttgg ccaaaccaat tgagctttaa gtgaaatgtg cgatatggta   1620

acagagaagg aaaaagacat aacgatagat ttgagctgct ggtgggaaat tctggtttag   1680

tgcccagctg gctgtacagg ctggttggac tttaggaggg aggtttgagc tggaaaataa   1740

agatggagag ttgtctttca gttttagatc atcagtgagg tcataagggt agatggagtt   1800

tacctgggaa aattaagtag ctattcgatt tggcttatta ttatgttaaa ataatacttc   1860

tctagtgaag tacttaatat gccagatact gtgccaagca ttttatatac atcctctctt   1920

ttactaagcc ctcatagggc aggtattttg attccaatca tactgattgg aactcctaag   1980

aaggtatctt gcttaaggtc ccacaacgaa taggtggcag atccagggta attcaggtct   2040

gtcagaacag tgattcttaa ttttttccct cctcagactc caggagtcac atgaagttat   2100

gcatcctgtc tgaccgaggc acaggcacac cacattttta tattccgctt ccaggatatc   2160

acaaacctga agcccatcct ccatggccca gagagaaaac ccaggacaaa accttggaga   2220

agactatttt catgaagaca aatggagaag gagcagtaga gtaaaaagag agcaaatcca   2280

gctgcctgta caatccatgc caccgaatgc cgtaagtgag acgtaaaagt tacgatactg   2340

aagagacgta acctgaccaa ggccacagag ctggaaaaag aagcaaagcc aagccgtttt   2400

tctcatgcac tgctcacaac aagcccctcc ttccactgac tcatgaaaaa cacactcata   2460

atgcccagcc cgcaccctaa tgaacagccc tcttaagagt ggtcatcaga cttcaatttc   2520

acagactaga attgagaaat ggaacaaaac cttgggatac cagccttcca ttttggtagg   2580

gatcatttaa aaaatggtag ggatcattta aaaaatgtgt tggtgtctga aacttacttt   2640

gaagtggtta aaaaacataa aatgtataga ttgtaacaag caaatatgtt aaaatgtact   2700

gtacaattct ttctttacaa ttttatggat gttcgaaatt taaaaaatac tagaaagaga   2760

atggtcttat tta                                                      2773


<210>  9587
<211>  47
<212>  PRT
<213>  Homosapiens

<400>  9587

Met Ala Gln Arg Glu Asn Pro Gly Gln Asn Leu Gly Glu Asp Tyr Phe 
1               5                   10                  15      


His Glu Asp Lys Trp Arg Arg Ser Ser Arg Val Lys Arg Glu Gln Ile 
            20                  25                  30          


Gln Leu Pro Val Gln Ser Met Pro Pro Asn Ala Val Ser Glu Thr 
        35                  40                  45          


<210>  9588
<211>  2108
<212>  DNA
<213>  Homosapiens

<400>  9588
cccgcttccg ctgccgcagc cggtcgtaac caagttgtgt cctgtcagcc gctgtcccct     60

tcgccgcgat gccgctggag aacctggagg aggagggtct gcccaagaac cccgacttgc    120

gtatcgcgca gctgcgcttc ctgctcagcc tgcccgagca ccgcggagac gctgccgtgc    180

gcgacgagct gatggcggcc gtccgcgata acagtgaggc ccgcacgagc gccgagtcag    240

cggcctaggc ctgggccgtc cccgcgttcc ggagcctgcg gggacttttt ttgatggagc    300

tccagacccc tctgacgggg tctcagagac caggcctggc ttctccggcc cttagggttt    360

tgctttggtt tggggatacc ctgggggacc tcgacttgcc tcagcggggt ctgcatctct    420

ctgtgccgcc ttcccctgta agggcagctt gggggagaat cgtgaggcat taatatttac    480

ccctgtgcta ggcacagagt aaaggccccg tgactttctg tcagtgggga ctgctcccgg    540

gcgcggggta ttcctgtggg agagttcagc ttgcctgtgg aagggaaatt tgggttcggt    600

tctttctggc ccttctgtag tgaatgtgta tgtttgaaca tatgtatgtg agtatgtgtg    660

tataaaaagt ctttccctgt ttgaagactt ttggaacaga atccggcaag agcaaaccga    720

ggattgccct ccctccagcc ctagtagagg ttggcattgc caggattggc cgtcacgcaa    780

acctcccacc agcatacgtt tatgttttgc caagccgatt attaagcgcc atcgcatgcc    840

ttcctgttag tggggaagag actggtggat gacttgtggc ggggcggggg gtgaaatacg    900

tgggcagact ttgacttgag ggcacaagtg tccccactca cacatccctc tttttgcatg    960

ttagacatgg ctccttacta tgaagccttg tgcaaatccc tcgactggca gatagacgtg   1020

gacctactca ataaaatgaa gaaggcaaat gaagatgagt tgaagcgttt ggatgaggag   1080

ctggaagatg cagagaagaa tctaggagag agcgaaattc gcgatgcaat gatggcaaag   1140

gccgagtacc tctgccggat aggtgacaaa gagggagctc tgacagcctt tcgcaagaca   1200

tatgacaaaa ctgtggccct gggtcaccga ttggatattg tattctatct ccttaggatt   1260

ggcttatttt atatggataa tgatctcatc acacgaaaca cagaaaaggc caaaagctta   1320

atagaagaag gaggagactg ggacaggaga aaccgcctaa aagtgtatca gggtctttat   1380

tgtgtggcta ttcgtgattt caaacaggca gctgaactct tccttgacac tgtttcaaca   1440

tttacatcct atgaactcat ggattataaa acatttgtga cttatactgt ctatgtcagt   1500

atgattgcct tagaaagacc agatctcagg gaaaaggtca ttaaaggagc agagattctt   1560

gaagtgttgc acagtcttcc agcagttcgg cagtatctgt tttcactcta tgaatgccgt   1620

tactctgttt tcttccaatc attagcggtt gtggaacagg aaatgaaaaa ggactggctt   1680

tttgcccctc attatcgata ctatgtaaga gaaatgagaa ttcatgcata cagtcagctg   1740

ctggaatcat ataggtcatt aacccttggc tatatggcag aagcgtttgg tgttggtgtg   1800

gaattcattg atcaggaact gtccaggttt attgctgccg ggagactaca ctgcaaaata   1860

gataaagtga atgaaatagt agaaaccaac agacctgata gcaagaactg gcagtaccaa   1920

gaaactatca agaaaggaga tctgctacta aacagagttc aaaaactttc cagagtaatt   1980

aatatgtaaa gccatgtaac taacaaagga tttgctttag agataattat ttggaatttt   2040

tatagcttac ttcacaatgt gcccaggtca gctgtataaa ataaatactg cattgttgtt   2100

tctttcca                                                            2108


<210>  9589
<211>  343
<212>  PRT
<213>  Homosapiens

<400>  9589

Met Leu Asp Met Ala Pro Tyr Tyr Glu Ala Leu Cys Lys Ser Leu Asp 
1               5                   10                  15      


Trp Gln Ile Asp Val Asp Leu Leu Asn Lys Met Lys Lys Ala Asn Glu 
            20                  25                  30          


Asp Glu Leu Lys Arg Leu Asp Glu Glu Leu Glu Asp Ala Glu Lys Asn 
        35                  40                  45              


Leu Gly Glu Ser Glu Ile Arg Asp Ala Met Met Ala Lys Ala Glu Tyr 
    50                  55                  60                  


Leu Cys Arg Ile Gly Asp Lys Glu Gly Ala Leu Thr Ala Phe Arg Lys 
65                  70                  75                  80  


Thr Tyr Asp Lys Thr Val Ala Leu Gly His Arg Leu Asp Ile Val Phe 
                85                  90                  95      


Tyr Leu Leu Arg Ile Gly Leu Phe Tyr Met Asp Asn Asp Leu Ile Thr 
            100                 105                 110         


Arg Asn Thr Glu Lys Ala Lys Ser Leu Ile Glu Glu Gly Gly Asp Trp 
        115                 120                 125             


Asp Arg Arg Asn Arg Leu Lys Val Tyr Gln Gly Leu Tyr Cys Val Ala 
    130                 135                 140                 


Ile Arg Asp Phe Lys Gln Ala Ala Glu Leu Phe Leu Asp Thr Val Ser 
145                 150                 155                 160 


Thr Phe Thr Ser Tyr Glu Leu Met Asp Tyr Lys Thr Phe Val Thr Tyr 
                165                 170                 175     


Thr Val Tyr Val Ser Met Ile Ala Leu Glu Arg Pro Asp Leu Arg Glu 
            180                 185                 190         


Lys Val Ile Lys Gly Ala Glu Ile Leu Glu Val Leu His Ser Leu Pro 
        195                 200                 205             


Ala Val Arg Gln Tyr Leu Phe Ser Leu Tyr Glu Cys Arg Tyr Ser Val 
    210                 215                 220                 


Phe Phe Gln Ser Leu Ala Val Val Glu Gln Glu Met Lys Lys Asp Trp 
225                 230                 235                 240 


Leu Phe Ala Pro His Tyr Arg Tyr Tyr Val Arg Glu Met Arg Ile His 
                245                 250                 255     


Ala Tyr Ser Gln Leu Leu Glu Ser Tyr Arg Ser Leu Thr Leu Gly Tyr 
            260                 265                 270         


Met Ala Glu Ala Phe Gly Val Gly Val Glu Phe Ile Asp Gln Glu Leu 
        275                 280                 285             


Ser Arg Phe Ile Ala Ala Gly Arg Leu His Cys Lys Ile Asp Lys Val 
    290                 295                 300                 


Asn Glu Ile Val Glu Thr Asn Arg Pro Asp Ser Lys Asn Trp Gln Tyr 
305                 310                 315                 320 


Gln Glu Thr Ile Lys Lys Gly Asp Leu Leu Leu Asn Arg Val Gln Lys 
                325                 330                 335     


Leu Ser Arg Val Ile Asn Met 
            340             


<210>  9590
<211>  1516
<212>  DNA
<213>  Homosapiens

<400>  9590
cccgcttccg ctgccgcagc cggtcgtaac caagttgtgt cctgtcagcc gctgtcccct     60

tcgccgcgat gccgctggag aacctggagg aggagggtct gcccaagaac cccgacttgc    120

gtatcgcgca gctgcgcttc ctgctcagcc tgcccgagca ccgcggagac gctgccgtgc    180

gcgacgagct gatggcggcc gtccgcgata acaacttttg gaacagaatc cggcaagagc    240

aaaccgagga ttgccctccc tccagcccta gtagaggttg gcattgccag gattggccgt    300

cacgcaaacc tcccaccagc atacgtttat gttttgccaa gccgattatt aagcgccatc    360

gcatgccttc ctacatggct ccttactatg aagccttgtg caaatccctc gactggcaga    420

tagacgtgga cctactcaat aaaatgaaga aggcaaatga agatgagttg aagcgtttgg    480

atgaggagct ggaagatgca gagaagaatc taggagagag cgaaattcgc gatgcaatga    540

tggcaaaggc cgagtacctc tgccggatag gtgacaaaga gggagctctg acagcctttc    600

gcaagacata tgacaaaact gtggccctgg gtcaccgatt ggatattgta ttctatctcc    660

ttaggattgg cttattttat atggataatg atctcatcac acgaaacaca gaaaaggcca    720

aaagcttaat agaagaagga ggagactggg acaggagaaa ccgcctaaaa gtgtatcagg    780

gtctttattg tgtggctatt cgtgatttca aacaggcagc tgaactcttc cttgacactg    840

tttcaacatt tacatcctat gaactcatgg attataaaac atttgtgact tatactgtct    900

atgtcagtat gattgcctta gaaagaccag atctcaggga aaaggtcatt aaaggagcag    960

agattcttga agtgttgcac agtcttccag cagttcggca gtatctgttt tcactctatg   1020

aatgccgtta ctctgttttc ttccaatcat tagcggttgt ggaacaggaa atgaaaaagg   1080

actggctttt tgcccctcat tatcgatact atgtaagaga aatgagaatt catgcataca   1140

gtcagctgct ggaatcatat aggtcattaa cccttggcta tatggcagaa gcgtttggtg   1200

ttggtgtgga attcattgat caggaactgt ccaggtttat tgctgccggg agactacact   1260

gcaaaataga taaagtgaat gaaatagtag aaaccaacag acctgatagc aagaactggc   1320

agtaccaaga aactatcaag aaaggagatc tgctactaaa cagagttcaa aaactttcca   1380

gagtaattaa tatgtaaagc catgtaacta acaaaggatt tgctttagag ataattattt   1440

ggaattttta tagcttactt cacaatgtgc ccaggtcagc tgtataaaat aaatactgca   1500

ttgttgtttc tttcca                                                   1516


<210>  9591
<211>  442
<212>  PRT
<213>  Homosapiens

<400>  9591

Met Pro Leu Glu Asn Leu Glu Glu Glu Gly Leu Pro Lys Asn Pro Asp 
1               5                   10                  15      


Leu Arg Ile Ala Gln Leu Arg Phe Leu Leu Ser Leu Pro Glu His Arg 
            20                  25                  30          


Gly Asp Ala Ala Val Arg Asp Glu Leu Met Ala Ala Val Arg Asp Asn 
        35                  40                  45              


Asn Phe Trp Asn Arg Ile Arg Gln Glu Gln Thr Glu Asp Cys Pro Pro 
    50                  55                  60                  


Ser Ser Pro Ser Arg Gly Trp His Cys Gln Asp Trp Pro Ser Arg Lys 
65                  70                  75                  80  


Pro Pro Thr Ser Ile Arg Leu Cys Phe Ala Lys Pro Ile Ile Lys Arg 
                85                  90                  95      


His Arg Met Pro Ser Tyr Met Ala Pro Tyr Tyr Glu Ala Leu Cys Lys 
            100                 105                 110         


Ser Leu Asp Trp Gln Ile Asp Val Asp Leu Leu Asn Lys Met Lys Lys 
        115                 120                 125             


Ala Asn Glu Asp Glu Leu Lys Arg Leu Asp Glu Glu Leu Glu Asp Ala 
    130                 135                 140                 


Glu Lys Asn Leu Gly Glu Ser Glu Ile Arg Asp Ala Met Met Ala Lys 
145                 150                 155                 160 


Ala Glu Tyr Leu Cys Arg Ile Gly Asp Lys Glu Gly Ala Leu Thr Ala 
                165                 170                 175     


Phe Arg Lys Thr Tyr Asp Lys Thr Val Ala Leu Gly His Arg Leu Asp 
            180                 185                 190         


Ile Val Phe Tyr Leu Leu Arg Ile Gly Leu Phe Tyr Met Asp Asn Asp 
        195                 200                 205             


Leu Ile Thr Arg Asn Thr Glu Lys Ala Lys Ser Leu Ile Glu Glu Gly 
    210                 215                 220                 


Gly Asp Trp Asp Arg Arg Asn Arg Leu Lys Val Tyr Gln Gly Leu Tyr 
225                 230                 235                 240 


Cys Val Ala Ile Arg Asp Phe Lys Gln Ala Ala Glu Leu Phe Leu Asp 
                245                 250                 255     


Thr Val Ser Thr Phe Thr Ser Tyr Glu Leu Met Asp Tyr Lys Thr Phe 
            260                 265                 270         


Val Thr Tyr Thr Val Tyr Val Ser Met Ile Ala Leu Glu Arg Pro Asp 
        275                 280                 285             


Leu Arg Glu Lys Val Ile Lys Gly Ala Glu Ile Leu Glu Val Leu His 
    290                 295                 300                 


Ser Leu Pro Ala Val Arg Gln Tyr Leu Phe Ser Leu Tyr Glu Cys Arg 
305                 310                 315                 320 


Tyr Ser Val Phe Phe Gln Ser Leu Ala Val Val Glu Gln Glu Met Lys 
                325                 330                 335     


Lys Asp Trp Leu Phe Ala Pro His Tyr Arg Tyr Tyr Val Arg Glu Met 
            340                 345                 350         


Arg Ile His Ala Tyr Ser Gln Leu Leu Glu Ser Tyr Arg Ser Leu Thr 
        355                 360                 365             


Leu Gly Tyr Met Ala Glu Ala Phe Gly Val Gly Val Glu Phe Ile Asp 
    370                 375                 380                 


Gln Glu Leu Ser Arg Phe Ile Ala Ala Gly Arg Leu His Cys Lys Ile 
385                 390                 395                 400 


Asp Lys Val Asn Glu Ile Val Glu Thr Asn Arg Pro Asp Ser Lys Asn 
                405                 410                 415     


Trp Gln Tyr Gln Glu Thr Ile Lys Lys Gly Asp Leu Leu Leu Asn Arg 
            420                 425                 430         


Val Gln Lys Leu Ser Arg Val Ile Asn Met 
        435                 440         


<210>  9592
<211>  1833
<212>  DNA
<213>  Homosapiens

<400>  9592
aggccttgcg acatggctgt tacatgacct tggttggtct gtttccctaa cctctttgtg     60

cctcatttgt cttacctact aaataggcta atagtactac ctcgcagcat gaagatgatt    120

ttaataagat gaatgagagt aacgactcga caaactatgg tgattgtttt tattaatgct    180

gttattacat tttcagtttt caaaaaattt taagctccca tcagttacaa acggaaagta    240

aaatagctaa aaagggagtg agaaagagat tcaagaaatt gggcttttga gttgggctgc    300

acccactctg ggactccgca gggggccttg agggtggaaa agcccccgtg accacacagg    360

ggcgcaggcg cccaggccgg gtgaggcgtt cccggaggtg tccagcagag gacgctgccg    420

gcggagacgg gaccggaagc cgggccgcag gcggccgggc gtattcgccg actcctcccg    480

cttccgctgc cgcagccggt cgtaaccaag ttgtgtcctg tcagccgctg tccccttcgc    540

cgcgatgccg ctggagaacc tggaggagga gggtctgccc aagaaccccg acttgcgtat    600

cgcgcagctg cgcttcctgc tcagcctgcc cgagcaccgc ggagacgctg ccgtgcgcga    660

cgagctgatg gcggccgtcc gcgataacaa catggctcct tactatgaag ccttgtgcaa    720

atccctcgac tggcagatag acgtggacct actcaataaa atgaagaagg caaatgaaga    780

tgagttgaag cgtttggatg aggagctgga agatgcagag aagaatctag gagagagcga    840

aattcgcgat gcaatgatgg caaaggccga gtacctctgc cggataggtg acaaagaggg    900

agctctgaca gcctttcgca agacatatga caaaactgtg gccctgggtc accgattgga    960

tattgtattc tatctcctta ggattggctt attttatatg gataatgatc tcatcacacg   1020

aaacacagaa aaggccaaaa gcttaataga agaaggagga gactgggaca ggagaaaccg   1080

cctaaaagtg tatcagggtc tttattgtgt ggctattcgt gatttcaaac aggcagctga   1140

actcttcctt gacactgttt caacatttac atcctatgaa ctcatggatt ataaaacatt   1200

tgtgacttat actgtctatg tcagtatgat tgccttagaa agaccagatc tcagggaaaa   1260

ggtcattaaa ggagcagaga ttcttgaagt gttgcacagt cttccagcag ttcggcagta   1320

tctgttttca ctctatgaat gccgttactc tgttttcttc caatcattag cggttgtgga   1380

acaggaaatg aaaaaggact ggctttttgc ccctcattat cgatactatg taagagaaat   1440

gagaattcat gcatacagtc agctgctgga atcatatagg tcattaaccc ttggctatat   1500

ggcagaagcg tttggtgttg gtgtggaatt cattgatcag gaactgtcca ggtttattgc   1560

tgccgggaga ctacactgca aaatagataa agtgaatgaa atagtagaaa ccaacagacc   1620

tgatagcaag aactggcagt accaagaaac tatcaagaaa ggagatctgc tactaaacag   1680

agttcaaaaa ctttccagag taattaatat gtaaagccat gtaactaaca aaggatttgc   1740

tttagagata attatttgga atttttatag cttacttcac aatgtgccca ggtcagctgt   1800

ataaaataaa tactgcattg ttgtttcttt cca                                1833


<210>  9593
<211>  389
<212>  PRT
<213>  Homosapiens

<400>  9593

Met Pro Leu Glu Asn Leu Glu Glu Glu Gly Leu Pro Lys Asn Pro Asp 
1               5                   10                  15      


Leu Arg Ile Ala Gln Leu Arg Phe Leu Leu Ser Leu Pro Glu His Arg 
            20                  25                  30          


Gly Asp Ala Ala Val Arg Asp Glu Leu Met Ala Ala Val Arg Asp Asn 
        35                  40                  45              


Asn Met Ala Pro Tyr Tyr Glu Ala Leu Cys Lys Ser Leu Asp Trp Gln 
    50                  55                  60                  


Ile Asp Val Asp Leu Leu Asn Lys Met Lys Lys Ala Asn Glu Asp Glu 
65                  70                  75                  80  


Leu Lys Arg Leu Asp Glu Glu Leu Glu Asp Ala Glu Lys Asn Leu Gly 
                85                  90                  95      


Glu Ser Glu Ile Arg Asp Ala Met Met Ala Lys Ala Glu Tyr Leu Cys 
            100                 105                 110         


Arg Ile Gly Asp Lys Glu Gly Ala Leu Thr Ala Phe Arg Lys Thr Tyr 
        115                 120                 125             


Asp Lys Thr Val Ala Leu Gly His Arg Leu Asp Ile Val Phe Tyr Leu 
    130                 135                 140                 


Leu Arg Ile Gly Leu Phe Tyr Met Asp Asn Asp Leu Ile Thr Arg Asn 
145                 150                 155                 160 


Thr Glu Lys Ala Lys Ser Leu Ile Glu Glu Gly Gly Asp Trp Asp Arg 
                165                 170                 175     


Arg Asn Arg Leu Lys Val Tyr Gln Gly Leu Tyr Cys Val Ala Ile Arg 
            180                 185                 190         


Asp Phe Lys Gln Ala Ala Glu Leu Phe Leu Asp Thr Val Ser Thr Phe 
        195                 200                 205             


Thr Ser Tyr Glu Leu Met Asp Tyr Lys Thr Phe Val Thr Tyr Thr Val 
    210                 215                 220                 


Tyr Val Ser Met Ile Ala Leu Glu Arg Pro Asp Leu Arg Glu Lys Val 
225                 230                 235                 240 


Ile Lys Gly Ala Glu Ile Leu Glu Val Leu His Ser Leu Pro Ala Val 
                245                 250                 255     


Arg Gln Tyr Leu Phe Ser Leu Tyr Glu Cys Arg Tyr Ser Val Phe Phe 
            260                 265                 270         


Gln Ser Leu Ala Val Val Glu Gln Glu Met Lys Lys Asp Trp Leu Phe 
        275                 280                 285             


Ala Pro His Tyr Arg Tyr Tyr Val Arg Glu Met Arg Ile His Ala Tyr 
    290                 295                 300                 


Ser Gln Leu Leu Glu Ser Tyr Arg Ser Leu Thr Leu Gly Tyr Met Ala 
305                 310                 315                 320 


Glu Ala Phe Gly Val Gly Val Glu Phe Ile Asp Gln Glu Leu Ser Arg 
                325                 330                 335     


Phe Ile Ala Ala Gly Arg Leu His Cys Lys Ile Asp Lys Val Asn Glu 
            340                 345                 350         


Ile Val Glu Thr Asn Arg Pro Asp Ser Lys Asn Trp Gln Tyr Gln Glu 
        355                 360                 365             


Thr Ile Lys Lys Gly Asp Leu Leu Leu Asn Arg Val Gln Lys Leu Ser 
    370                 375                 380                 


Arg Val Ile Asn Met 
385                 


<210>  9594
<211>  1344
<212>  DNA
<213>  Homosapiens

<400>  9594
aagaatgtgg attttagagt tctagatagg ggttttcatt taggccttgc gacatggctg     60

ttacatgacc ttggttggtc tgtttcccta acctctttgt gcctcatttg tcttacctac    120

taaataggct aatagtacta cctcgcagca tgaagatgat tttaataaga tgaatgagag    180

taacgactcg acaaactatg acatggctcc ttactatgaa gccttgtgca aatccctcga    240

ctggcagata gacgtggacc tactcaataa aatgaagaag gcaaatgaag atgagttgaa    300

gcgtttggat gaggagctgg aagatgcaga gaagaatcta ggagagagcg aaattcgcga    360

tgcaatgatg gcaaaggccg agtacctctg ccggataggt gacaaagagg gagctctgac    420

agcctttcgc aagacatatg acaaaactgt ggccctgggt caccgattgg atattgtatt    480

ctatctcctt aggattggct tattttatat ggataatgat ctcatcacac gaaacacaga    540

aaaggccaaa agcttaatag aagaaggagg agactgggac aggagaaacc gcctaaaagt    600

gtatcagggt ctttattgtg tggctattcg tgatttcaaa caggcagctg aactcttcct    660

tgacactgtt tcaacattta catcctatga actcatggat tataaaacat ttgtgactta    720

tactgtctat gtcagtatga ttgccttaga aagaccagat ctcagggaaa aggtcattaa    780

aggagcagag attcttgaag tgttgcacag tcttccagca gttcggcagt atctgttttc    840

actctatgaa tgccgttact ctgttttctt ccaatcatta gcggttgtgg aacaggaaat    900

gaaaaaggac tggctttttg cccctcatta tcgatactat gtaagagaaa tgagaattca    960

tgcatacagt cagctgctgg aatcatatag gtcattaacc cttggctata tggcagaagc   1020

gtttggtgtt ggtgtggaat tcattgatca ggaactgtcc aggtttattg ctgccgggag   1080

actacactgc aaaatagata aagtgaatga aatagtagaa accaacagac ctgatagcaa   1140

gaactggcag taccaagaaa ctatcaagaa aggagatctg ctactaaaca gagttcaaaa   1200

actttccaga gtaattaata tgtaaagcca tgtaactaac aaaggatttg ctttagagat   1260

aattatttgg aatttttata gcttacttca caatgtgccc aggtcagctg tataaaataa   1320

atactgcatt gttgtttctt tcca                                          1344


<210>  9595
<211>  351
<212>  PRT
<213>  Homosapiens

<400>  9595

Met Asn Glu Ser Asn Asp Ser Thr Asn Tyr Asp Met Ala Pro Tyr Tyr 
1               5                   10                  15      


Glu Ala Leu Cys Lys Ser Leu Asp Trp Gln Ile Asp Val Asp Leu Leu 
            20                  25                  30          


Asn Lys Met Lys Lys Ala Asn Glu Asp Glu Leu Lys Arg Leu Asp Glu 
        35                  40                  45              


Glu Leu Glu Asp Ala Glu Lys Asn Leu Gly Glu Ser Glu Ile Arg Asp 
    50                  55                  60                  


Ala Met Met Ala Lys Ala Glu Tyr Leu Cys Arg Ile Gly Asp Lys Glu 
65                  70                  75                  80  


Gly Ala Leu Thr Ala Phe Arg Lys Thr Tyr Asp Lys Thr Val Ala Leu 
                85                  90                  95      


Gly His Arg Leu Asp Ile Val Phe Tyr Leu Leu Arg Ile Gly Leu Phe 
            100                 105                 110         


Tyr Met Asp Asn Asp Leu Ile Thr Arg Asn Thr Glu Lys Ala Lys Ser 
        115                 120                 125             


Leu Ile Glu Glu Gly Gly Asp Trp Asp Arg Arg Asn Arg Leu Lys Val 
    130                 135                 140                 


Tyr Gln Gly Leu Tyr Cys Val Ala Ile Arg Asp Phe Lys Gln Ala Ala 
145                 150                 155                 160 


Glu Leu Phe Leu Asp Thr Val Ser Thr Phe Thr Ser Tyr Glu Leu Met 
                165                 170                 175     


Asp Tyr Lys Thr Phe Val Thr Tyr Thr Val Tyr Val Ser Met Ile Ala 
            180                 185                 190         


Leu Glu Arg Pro Asp Leu Arg Glu Lys Val Ile Lys Gly Ala Glu Ile 
        195                 200                 205             


Leu Glu Val Leu His Ser Leu Pro Ala Val Arg Gln Tyr Leu Phe Ser 
    210                 215                 220                 


Leu Tyr Glu Cys Arg Tyr Ser Val Phe Phe Gln Ser Leu Ala Val Val 
225                 230                 235                 240 


Glu Gln Glu Met Lys Lys Asp Trp Leu Phe Ala Pro His Tyr Arg Tyr 
                245                 250                 255     


Tyr Val Arg Glu Met Arg Ile His Ala Tyr Ser Gln Leu Leu Glu Ser 
            260                 265                 270         


Tyr Arg Ser Leu Thr Leu Gly Tyr Met Ala Glu Ala Phe Gly Val Gly 
        275                 280                 285             


Val Glu Phe Ile Asp Gln Glu Leu Ser Arg Phe Ile Ala Ala Gly Arg 
    290                 295                 300                 


Leu His Cys Lys Ile Asp Lys Val Asn Glu Ile Val Glu Thr Asn Arg 
305                 310                 315                 320 


Pro Asp Ser Lys Asn Trp Gln Tyr Gln Glu Thr Ile Lys Lys Gly Asp 
                325                 330                 335     


Leu Leu Leu Asn Arg Val Gln Lys Leu Ser Arg Val Ile Asn Met 
            340                 345                 350     


<210>  9596
<211>  2947
<212>  DNA
<213>  Homosapiens

<400>  9596
agcggttgtg gaacaggaaa tgaaaaagga ctggcttttt gcccctcatt atcgatacta     60

tgtaagagaa atgagaattc atgcatacag tcagctgctg gaatcatata ggtcattaac    120

ccttggctat atggcagaag cgtttggtgt tggtgtggaa ttcattgatc agtaagtttg    180

aataatgcca tgttaattga agttttaaag ttgcctttta aaatatgtga acttgtacaa    240

ttttttactt gtttacattg gttccctcaa tcttaacggg gaggggagag gtttttttcc    300

tcagtattat caaaacattc gtatcctgtt gcctctgcct tcctcatgtc atgtctgccc    360

cttgcattaa cagatgggaa gatgagttgt agtgaggcta agtgatttgt taaaggtcat    420

tagaccagtt gttatcaaaa gttgtcttct gttacttctt tgtagaccac actgcagcta    480

cggtaatgac tcttagatct gatatttaca gttggtcata ttccctctga taattccttc    540

cagtttttag gttgctgctg caattctggt cagattggtt gttaaatgtg ggacttttag    600

tacttgcatc agtgattaaa caaataaata cttaatgagc cattcattac tatatgtttg    660

gtattgtttt acagctccct tttcacactt tcattgtagt agtagggaag agatggcaag    720

gaagcaaata aatataaaac gtaatttcac atatagaaat gaacctatgg agatgagaaa    780

atgctatcct tacgtacggc atgcttaagg aggtgaggtt tgctctgaga tttgaattga    840

gaggagtcag ccatatggag tccttctgcg tgcagaaaag ggaatagaaa aggctaaggc    900

tttgagccag gaataagctt ggatgttgta ggaacagaaa atgtcagggt ggctccagca    960

tagttggagt ggtaggagat tttgaggata atatatggag agttaggtag gtaatgattt   1020

gtgtagggcc ttgtaggtca tgggatggag cttgagtttt aagtaagttt gatagggagc   1080

cattggaaga tttagagccc aagttacatg gtcctatgca gtgtctttat ataagaaata   1140

gagtaaggtg gcagagagga ccagttgtgc tgtttagtag ctcttagagg agatgttacc   1200

gtggcgtgga cgagggtggt gagagtagag ttgggtagga gacatactca atatgggatg   1260

tccagatggc atctagatca gtggctccca catgtaggtg tttttaaatg ttgatgatgg   1320

tgttttcaat ggtctgcagt ggaaacttta aatgaagatg catttctttt aaataagacc   1380

attctctttc tagtattttt taaatttcga acatccataa aattgtaaag aaagaattgt   1440

acagtacatt ttaacatatt tgcttgttac aatctataca ttttatgttt tttaaccact   1500

tcaaagtaag tttcagacac caacacattt tttaaatgat ccctaccatt ttttaaatga   1560

tccctaccaa aatggaaggc tggtatccca aggttttgtt ccatttctca attctagtct   1620

gtgaaattga agtctgatga ccactcttaa gagggctgtt cattagggtg cgggctgggc   1680

attatgagtg tgtttttcat gagtcagtgg aaggaggggc ttgttgtgag cagtgcatga   1740

gaaaaacggc ttggctttgc ttctttttcc agctctgtgg ccttggtcag gttacgtctc   1800

ttcagtatcg taactgtaat gtggagataa agccttcatt agttaggggc acacaccgca   1860

gtattcctta agtcatcttg atgacaagtg aatgcaaggc agctggtacc tttcaggtag   1920

tagttgaatt caggtagtat ttgttcagtt tttttttttt cccttcatgt tctaagacca   1980

gcttgagagg caaaggttgt accactgagc tctagttgtt gttacctaaa aaggccttgt   2040

tttaaatttc tgtgatacct aagaatttca aatctgggtt gtcatggatt ctttattctt   2100

tttttctccc ttaaaaagtt acattttaga tgaaatcccc ttttttaaaa tgggcaaagc   2160

aataattcta catcatttct ccccttccct tccacttgtt tagactaaga tatgttagag   2220

agggaaaggg tcgttgtttt agtaaatact attgctgttg acatgttaat actattgctg   2280

ttgacatgtt tactgatggg ctgtgttcca taattttgtt ttaggtcttt tgtttgaaac   2340

agtttactgt ttttatcagt tttggtccct aatttttcct aacctacagt ttttctctga   2400

gtacatatgg tttcattgtt tgatctactt tctatctatc tgaatatgaa cttctaggat   2460

catgtttatt ctagtagatg atgacttaaa gcctgcagta taggagggac aacgtcaact   2520

actgcatgtg caataacaag cttgaaggga agctaaatgt ttgttacaaa tttaagacag   2580

tattttaatg ccgtttgcat ttttctaaga attttctata aagctaattc tgttattttt   2640

tgtctctaaa ttagggaact gtccaggttt attgctgccg ggagactaca ctgcaaaata   2700

gataaagtga atgaaatagt agaaaccaac agacctgata gcaagaactg gcagtaccaa   2760

gaaactatca agaaaggaga tctgctacta aacagagttc aaaaactttc cagagtaatt   2820

aatatgtaaa gccatgtaac taacaaagga tttgctttag agataattat ttggaatttt   2880

tatagcttac ttcacaatgt gcccaggtca gctgtataaa ataaatactg cattgttgtt   2940

tctttcc                                                             2947


<210>  9597
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  9597

Met Ser His Ser Leu Leu Tyr Val Trp Tyr Cys Phe Thr Ala Pro Phe 
1               5                   10                  15      


Ser His Phe His Cys Ser Ser Arg Glu Glu Met Ala Arg Lys Gln Ile 
            20                  25                  30          


Asn Ile Lys Arg Asn Phe Thr Tyr Arg Asn Glu Pro Met Glu Met Arg 
        35                  40                  45              


Lys Cys Tyr Pro Tyr Val Arg His Ala 
    50                  55          


<210>  9598
<211>  4587
<212>  DNA
<213>  Homosapiens

<400>  9598
ggcccagtgt ttttggatgc tttctccatg catataaatt gggctgcttt atgagaattc     60

atagtattta cctcaggtaa tgtaggaaca ggtttcccga gcatgatgag taactcactt    120

ggccttatct tctcatacat acacacacag ttatgttgct tttgcatata aggttatatt    180

gtagaattgc tcttttccct tttttatgct tgaggtctcc tggtcatcac tcaactcaaa    240

tatggagccc ttccctgctt ccctcagtca gaacaaatct tacttctctg cattcctggg    300

attcttattg tatgctccct ccttcaaaaa aattgaggga gcccttcctt gcttccctca    360

gtcagaacaa atctcttact tctctgcatt cctggggtta ttgtatgccc cctcctttaa    420

aaaaactgag gtataaatca cacaccataa aattacctca agtgtacaat tcagtgcttt    480

ttcatatatt ggcaaggttt tgcaaatatt aataattcca gaacatcttg atcaccccaa    540

aaggaaaccg acacccatta gcagtcactc cctattactc ctttccccca gcccctggca    600

accactgatc tactttatgt ctgtacgaat ttgcctattc tggacatatc atctaaatgc    660

agtcataaaa tacgtggctt tttgtgcctg gcttctttca ctttataatg ttcccacatt    720

catccatgtt gtagcatgta tcagtatttc attttgtttt atagccaaat gatagtctgt    780

tgtatgtata tactacattt tatttatcca ttcattagtt catagatttt tgtgttgatt    840

gcactttttg gctactatca ataatgctat aatgaagatt tgtgtacagc tttttctgtg    900

gacatatgga gtggaatggc tgcatcttaa tggcaaccct ctgataaact ttttgaggaa    960

ctgccagttt tctaaagcag gcgcccgcac catttgacat tcccatcagc tgtgtgaggg   1020

ttccagtgtt cccacatcca gtacttacta ttttctgtct ttttgattat aggtatcttt   1080

gtgggtgtga aatgatatct cattgtaatt ttgatttgtt tctaatgact agtttcattg   1140

agcatctttt catatactta actggccatg tgccccaatt gctaaaactt agcactctgt   1200

tttgtgataa tttcctagtt tgcctccttt gctaactaga atttctggga gcagaactta   1260

tgcttttttt tttttaatct tcatgaccct gacagcagga cagcacttgg tactaatgtg   1320

ctctaaaata attcaattgg aaaaggaagt agtatccttt tctaggtagt acctgactat   1380

atttagaaat caaaaataaa ttgagaaagt gaaaggtttt gtatctcacc tcacccccaa   1440

atccatacac acattcactc acatataaaa tttttcctga gacggtgatt ttaatattgt   1500

tttatatcct tgtagacctt ttatttattt atttatttat ttatttgaga cagagtctca   1560

ctctgtcgcc caggctggag tgcagtgaca tgaccttggc tcattgcaag ctccgcctcc   1620

cgggttcatg ccgttctcct gcctcagcct cctgagcagc tgggattaca ggcgcccgcc   1680

accatgcccg gctaattttt tgtattttta gtagagacag ggtttcactg tgttagccag   1740

gatcgtcttg atctcctgac ctcacgatcc gcccgcctca gcctctcaaa gtgcaggatt   1800

atagacgtga gccaccgcgc ccggcctttt actcgtttat tatatgcact ttaaaaaaga   1860

aaaaacattt aaaaaccgaa gttatatgta cacatggaac agttgtaaac agtatcatat   1920

aaagaagaaa aaggctttct ttaatatctg atcaccagtg tcctttctct agaggcaact   1980

gctgttaatc aggttttcca gtgtgtcctt caggggcact gttatccaga gataagagca   2040

tgtaacactt ttgtgtattg tggatgtatt ttatatgctg ttttgtaagt accttttttt   2100

ctcttcacaa gtaacgtgta tatcttttca tgtcactata catatagttg gtcatttagt   2160

cagtaagtgt ttttgagtgg ctatcgtgta ctaacattga gaatagcagc aaattgaaca   2220

ggtagtgttc ctaggagctt caggttatcc tttcttaagg acttcctagt atttcaatgt   2280

attggctatg ccataattta tcctctactg atagaaaacg aggtcgtttc cagttttgcc   2340

ctattataag caaccctgtt ttgaacactc caacaattta tctttcccac ttgttatttc   2400

cttggggaaa aagtctaaaa aattgaactt tccaaaggtt aaatatattg tgtcttgacc   2460

actgttgccc tccagagata tgtcagttta catttacaca atttatactt ctctcaatct   2520

atagcatttg agagaacctg tcccaccctc tccatactct ttgccagtct gagaggacag   2580

aaataatttt attgatgttt tatgcatttc tcttattagt gagaatacgc accatctcat   2640

ggttagtggc cattgatctc catgttgcta aatcatgtgt tcccttgctt atctttatct   2700

gccttgatgt tgaccatcct ttgcttctca ccacagcttt ctcttggttc tgcagtaacg   2760

tgctcttgtt ttctctggac ctacctcctc atccactgtt agacctctca gtgtctgact   2820

gccttagact gggttattgc ccttgtttct tatcttcact ttgtgccatc agatacattt   2880

ggatggcagt gatggacaaa ttcatgtcgc cagccccaaa ctggagcacc agactcatgc   2940

ctcaatgcct ccttagtgtc ctcacttggc tgtttaatag gcatatccac ttgaacactg   3000

ccaaagtatg cttgaatccc accctcaccc ccaacactaa aaacaaatat tctccttctc   3060

cagggatttc catcttgttg aaaccacaaa cataagtata ctctagagtc tcttttcttg   3120

ctcaccttct atatacctgt tgctgtcttc ctgcttgcat tctgagtctg gcatcctttc   3180

tgttcctggg cttaaccatg cttttcctgc cttcagactt ttgtatcatt tacattgctc   3240

tgtgcttagc cagcccctga gagaggtatt ccctgtccac cccaatccag tggagggctt   3300

cctagtcact ctatcatgtt acttttattt tcttcacagg atttatcttg tatatttgtt   3360

catctgtctc tgccctttga aaatttagtt tttgtggcag caagggtctt gtcttctggt   3420

tcactgccat ataactatct agagtagtga tatacaggag ttattcagta aaataattta   3480

tatttgtgtg gattgctcat taatactcta cgtacatttt actgtcttct aaggatctct   3540

tctggattaa ggccattaac tcatcgttat aaattttcta gtttatcatt tgtcttcaaa   3600

ccttgttcat agtgttttct tacgtagact atttacgtga acaaataaac aggcaatagg   3660

agtcatcagt ctttgctttc ttctgagttt tgttgctttt tgaaaatgtc tgatttatac   3720

cttttttctg gtctgtataa atcgtttttc actgtacctg ctgtttctct gttagaattg   3780

tttaaaaaat gatttttact ttattttact taaggcataa gaagttctcc gtggttaaaa   3840

tattagtacg tgaactttgt catctatgaa caagttcctt tagaagctga gctctgatag   3900

tgatgtcaaa tagccacctg ttacttgaag acgatgtttg catacctggc ccctccttta   3960

tcactgctgt tgctgccatt gttgatgaca tgatgtggaa gggcagtgag aaatttgata   4020

cttgttcatc tatctgttgg actcaactag tagtgttgct ttagttttta atctttttat   4080

ctgaaacgga gagtctatta taatttgtca ttttattcat tgcagcggtt gtggaacagg   4140

aaatgaaaaa ggactggctt tttgcccctc attatcgata ctatgtaaga gaaatgagaa   4200

ttcatgcata cagtcagctg ctggaatcat ataggtcatt aacccttggc tatatggcag   4260

aagcgtttgg tgttggtgtg gaattcattg atcaggaact gtccaggttt attgctgccg   4320

ggagactaca ctgcaaaata gataaagtga atgaaatagt agaaaccaac agacctgata   4380

gcaagaactg gcagtaccaa gaaactatca agaaaggaga tctgctacta aacagagttc   4440

aaaaactttc cagagtaatt aatatgtaaa gccatgtaac taacaaagga tttgctttag   4500

agataattat ttggaatttt tatagcttac ttcacaatgt gcccaggtca gctgtataaa   4560

ataaatactg cattgttgtt tctttcc                                       4587


<210>  9599
<211>  108
<212>  PRT
<213>  Homosapiens

<400>  9599

Met Lys Lys Asp Trp Leu Phe Ala Pro His Tyr Arg Tyr Tyr Val Arg 
1               5                   10                  15      


Glu Met Arg Ile His Ala Tyr Ser Gln Leu Leu Glu Ser Tyr Arg Ser 
            20                  25                  30          


Leu Thr Leu Gly Tyr Met Ala Glu Ala Phe Gly Val Gly Val Glu Phe 
        35                  40                  45              


Ile Asp Gln Glu Leu Ser Arg Phe Ile Ala Ala Gly Arg Leu His Cys 
    50                  55                  60                  


Lys Ile Asp Lys Val Asn Glu Ile Val Glu Thr Asn Arg Pro Asp Ser 
65                  70                  75                  80  


Lys Asn Trp Gln Tyr Gln Glu Thr Ile Lys Lys Gly Asp Leu Leu Leu 
                85                  90                  95      


Asn Arg Val Gln Lys Leu Ser Arg Val Ile Asn Met 
            100                 105             


<210>  9600
<211>  305
<212>  DNA
<213>  Homosapiens

<400>  9600
ccaccctcac ccccaacact aaaaacaaat attctccttc tccagggatt tccatcttgt     60

tgaaaccaca aacataagta tactctagag tctcttttct tgctcacctt ctatatacca    120

agaaactatc aagaaaggag atctgctact aaacagagtt caaaaacttt ccagagtaat    180

taatatgtaa agccatgtaa ctaacaaagg atttgcttta gagataatta tttggaattt    240

ttatagctta cttcacaatg tgcccaggtc agctgtataa aataaatact gcattgttgt    300

ttctt                                                                305


<210>  9601
<211>  39
<212>  PRT
<213>  Homosapiens

<400>  9601

Asn His Lys His Lys Tyr Thr Leu Glu Ser Leu Phe Leu Leu Thr Phe 
1               5                   10                  15      


Tyr Ile Pro Arg Asn Tyr Gln Glu Arg Arg Ser Ala Thr Lys Gln Ser 
            20                  25                  30          


Ser Lys Thr Phe Gln Ser Asn 
        35                  


<210>  9602
<211>  6503
<212>  DNA
<213>  Homosapiens

<400>  9602
ggcagcagtc actccagatg gcccgctgaa gctgggagtc ctgagttaat ttcaagccaa     60

atttctcact ccctggagga gcagagtgga gggtgtgtgt gcatggagaa gtccaagatt    120

tcatatctgg aaaagaagac tgggagaggc cagcatgaat ggccactgtc ctcgccaaat    180

ctggatggta tgtcttaggt gggattacat gaagaataag atgaagtctt acctcacctc    240

tgcaaaatga agactgccta tagtaattgg cagagaacat gaaaatggcc aaggagtttc    300

atcaatcaag gaacttaaaa ctccaaattg gactcgcaca atttctacca gaaacctgcc    360

actttagtag cacggtattg caaattattt cttaatcagt ttgccaagca gtttacaaac    420

ttactataca aacgtaatag agttaattct ccggaggctc ggataattaa tgaagcattt    480

agatatgaag atagcatgcg gaaaacagcc acaaccaaca tgtgcattgc ttttttaaaa    540

aaatcagtga caatgacaaa tgtcatatta atacctgaaa agcaaattat tttaatacat    600

cccgaatgga gtgccattac catgtccttt acagccttcc tttcctcaga cccatctggg    660

acggggtctg aaatgccact tttgacattc tctccataaa aaatactaga aaatgttaac    720

tactatactg aaaagagatc acgctcacct caccatggca gatggccact gagatacacc    780

gggcactaca tcgacagtac atctcactac aggtgggtca tccgatggat tatttcaact    840

gccacaatcc attaagggga ggaggaggat ggaagaaacc aagtgcttca tttttaactg    900

aagcaaggta gggagtttta ttttactata aacagcacaa ccgttaaatg tcttcattaa    960

gcaaactcac ttttgagccc attttctgac caacagtcct caaagttcaa aatggaaata   1020

ccctcccaac aaagcctgtt tttttaaaga cattgcacca ctgaaatctc agcagctcaa   1080

ccttcctggg taatccagat actctggtta ctaagctggt tacactggac tctttctaca   1140

atctctggga gctcttcgag gtggttgtca cctgtcctct gtttcatttc cagttcttct   1200

tttccctgac ctgccttcag attctccttt aacttctacc cttgacctgc cttctgtttt   1260

caaatagcct tgttccttct ccaggcatga catgtcacac accgtccctc gcagagcccc   1320

ctcagaatcc ttctgtccct caatcccaaa tgcttaagtt catttgcttt gaggacaacc   1380

ggttgtcagg ctaaggcagc agttctgtct gccttggtaa aggaaagcag ataatacaat   1440

ccaggaaaca tgagcaccag aacataatgc cacattcaaa acaacgtcat gctgacatca   1500

cacaatggca ccactcacag tcacttttac tttccccaag ggatagatca acattaagta   1560

acttcaacat tcccagcagg gatggcattt ctcacagaat tttactgaca ccggttggtt   1620

tctctaattg gcaaaaatta catttgcaat ttaaaaaaaa attactacca ctttgtagaa   1680

aataaattct actgagggtg ggagcagact taaggatggc tccttaagat ggaacggagc   1740

ataaaatgct ttgggtctaa cagttatgtt ttttcagcca caaaaagcca aattgaatat   1800

gttcctttga aaaaggtctc actgacatgt aacaaatttg tatagaaaaa aaaaaaaaaa   1860

aaaaaaaggt ggtaccgggc cacatttcaa tactactcag agacaatggt ggatgtgcat   1920

gcaagtcccc actgagtcct acgatataga aattcctttg atattacaaa atacaaaaat   1980

attttatcag aactctcatt tacattgcat ttacaatgga catgtaaata acttagtctt   2040

gggtcctggc taataaacaa attacttact gaaaaaaggg tcctaaaagt aagagaacca   2100

gagaggataa aagcgagcag gaaacaattt accatcttga gagatggcaa ctcaacacag   2160

aactgatggg aaggaagtga ccaagcctgg cctcgataga gtctactgtg tttccaaagt   2220

gaaatgtgca aataatattc aacatgccaa gaactgtgac tacctattga gtcaacctgt   2280

aaccttgcct ccatctactg acagcatttt cccttttctc ccccataagc cacccccaaa   2340

agcgctttaa catttaaaac agtgcaagtt tctgacttta cattcttagc tcccatcttc   2400

tcccattccc tgatcccaat catattaaga aatgatacag tttttgctct tctgtctttt   2460

cctgctgtgc aactgtcctc tgccacctaa tgtggaagat ttggggaggc cgtaggagct   2520

gtatttgtgc agcagctcat cgcttgtgac gtatcgcagg cgcgctggct gggggatggg   2580

ttctcctagg aaatagccct cgttgtcaga ctctgaagag gaggagcagg tggaacacca   2640

atcatactcg gcgaagtagg gtccccagcg gtccccaaag gcattctgca aagccaggtc   2700

cgacacagtc ctagggcact ggccgtacag gtccctccgg gacccatgcc ccatgctctc   2760

ctggaagctc cgctggcgca taaattggtc atagtcctcc ctggctctca gagggggcct   2820

atcttttaac cgggagatgg cctcgcgttc gctggccagg tggagggcgt tgtcggagcg   2880

agagcgtcgg gaacgcctgg acctgtgagg tcggaaacgg cggttgtcgt cgcgtgaagt   2940

agctcttctc cgggtgcgtt cactcatggg ctggatcctc acgccctcct gccctggcag   3000

cttgctgccc gccatccctc catcaaaatc aaagctctga tgcatccttc cgtgggactg   3060

caggtctctg tagccaatgg ggttgctgag ctggtggagg tttccctcca tctcctggta   3120

ctgctgggca gagagcaggc tgcgaactga ctctgcgctc cggaactgca tggacgagtt   3180

aagagtgccc atgttgctca gcttctcaga cacattcatt ccagagtctt tgctgaggtc   3240

aggcatggaa aatcgggata ggtgctcctg gcgcttggca ccaccatcag cagagaggcc   3300

tggggaagag aggaggggac cacagagatt aatacagatg tgcagcaatg ggtatcactg   3360

tcactgctgg tcatctatct agggtcatta tataccgttg tgaagttgtg tactgcacaa   3420

aggccctctc agggggcaca tgtgcctgtg agggggttct ctccactcca cagtaggtca   3480

ctatctacct agagggggca cttacttaaa atgcttccag agatgtattt taccagttac   3540

tagttcctcc aaaggctcat caaagttact aagagcccac tgtgtatcct atgtatgatg   3600

cttcctctat ttggagtttc actttgcaaa gtactttaat tacatttttg attctaatca   3660

tgcactataa gctctgtagg acagatattt tggatgagca aactttaagc tctagaggct   3720

ggatcatgcc caagctgttt ctggcaatac caaacactgg ttccacaata ttgggccagt   3780

tcacttctct gttagcccgc agcagtttcc tgctttgcct gctgtcccta agtggcaggt   3840

ggctccctat caaaagtgtc ttggacacta agtgactccc tagatataga tagagaaata   3900

tttactctct cagaccattc agtgaatgct ccaaggttgt aaatgggtct ctagcagcca   3960

gaagatgtgt gtgggacccc aagggacctc tcggtcgcac ggggagggac tttcaaaagt   4020

aaagcagtgg gtttgatgct ctcaaacagt gggtgcccca gcaatggacc tccatttctt   4080

aactgctgtc aaatgagctc ttggcatccc tgagatgaaa accattttga aggtagtggg   4140

agatactgac tgcagtaact tccattttgc tcattttcag gcagagctct ctaaggagat   4200

gtttaagaat gggccaggtg gcaaagtctc agcattttcc actcattaca tattgcaagg   4260

atcagcaatt tgccattcct ggtcatagac aacatgcctt tggattgcaa tggcccatta   4320

tcacccctgc tactgattat tcctgtctcc tactggggcc tccaacttcc tcttccgtga   4380

caaaacctaa agcagtgtta cgagcacttt gcaaaattac ttggcaatat ttactaaagc   4440

taaatacaca tatacgtata tgaattataa ataaagccgc tctgaatatc cttggccatt   4500

ttttgtggac ttatgaattt ctgttgggtg tacgaccaag agtagaaatt ccacaattct   4560

ccatcttcac tcttgattat atattcatca gaagttagta agaaggtcca agaaatggac   4620

aagggtactc agagaagctt tcttgtaata gcccagaaac ggaaacaact caaatgtcaa   4680

ttatcaggaa aatggataaa tatattgtgg ttttttctac cattccccac taaaaggaat   4740

ccaggctctt tagaaagatg gccaattcca ggataaaggc aaggaaatta aaagaaccag   4800

gatcttgtta tgccataaag tgagaaagta ttaaaaataa gatatggcag gggtttgtca   4860

gaaggacaca gggcctaact tgaaggggcc cccactggcc aaatctgaac aatttgagca   4920

ctcaaatatt taagtgaagt aatgatttat aaaccactga aacaaatagg aattcacaag   4980

tccatgctga tagcagataa ataaaaacat aaataaatac acaaacaggg aaaagagagg   5040

gctctatgta tagtggaatg ccaaccgctg tcagtagagt aagttcacaa gaaggaaggg   5100

ggtgccagat ttggaaagtc attttataac cattggaggt agagtgcttc acacaagaat   5160

caaaaagtgt gctaaattta gggggtaaaa tttgatgggg gagagcattg ttttaaagtg   5220

tttccctaca cattgcttat tagttgcaag ggaagaatta gtaactaaac aaaggtaaaa   5280

tcagacaaca ccttgacctt aagttcaaac ttaacatccc tggtgagatg caactgcacc   5340

ctgcatgcct ccagttgaga tgtactcaga agggcacact atcccttatg tagtattcca   5400

gtcaagaatg tattacccga atgcattcag gaggaaacat tagacagatg ccaaaaggag   5460

ggacatttgt tatgaaaaaa gggactgtag tcttaagacc agacaagact gagagaatgt   5520

tctagatgaa agggtacgag ggaaacatgg caattacata taatacctga tcctggactg   5580

gaacctgctc tttagggaaa ctaaatgcta taaagtaggg gttcccagac ctcaggctac   5640

agactggtta ggagcagggc cacacagaag gaggtgagtg gtcagtaagg gaagcttcat   5700

ctgcatgtac agccactccc cattgctcca actactgcct gacctctgcc tcctgacaga   5760

tcagcagcag cattagactc tcataggagt gtaaaccctg ttgtgaactg ctcatgcagg   5820

atctaggttg tgtgctcctt acgagaatct catgcctgat gatccataac tgtctcccat   5880

tacccctaga tgggactgtc tagttgcagg aaaacaagct caggtctccc actgactcta   5940

ccttaaagtg agttgtgtaa ttatttcagt atatattaca atgtagtaat aatagaaata   6000

aagtacataa taaatgtaat gcacttgaac catcccaaag ccatccccac cccctggccc   6060

cagtctgtgg aaaaattatc ttccataaaa ccggtccctg gtgccaaaaa ggttggggac   6120

tgcctctata aaggataact tttggtcaac tgaaaaaaaa atggaacatg ggcaatagat   6180

aaaagtatta tgctaaattt actgtggtca attaataatg gtgataatgt gggagaagat   6240

ctttactctt gggaaatata tatggaagga tatggtggta aatggcccag atggatgcaa   6300

tttgctctca aatggtttat aaataaaatg tgtgtgtgtg tgcgtgtgtg tgcatgcatg   6360

tgaacatgaa agaacaaatg tggcaaaagg ttaacaatgg atcaatctac gtaaagagta   6420

cattacaggt gttgtttgtt ctatttttat aacttttttt aagtctgaaa ttatttccaa   6480

ataaaaagtt tctttaacat tag                                           6503


<210>  9603
<211>  38
<212>  PRT
<213>  Homosapiens

<400>  9603

Met Lys Met Ala Lys Glu Phe His Gln Ser Arg Asn Leu Lys Leu Gln 
1               5                   10                  15      


Ile Gly Leu Ala Gln Phe Leu Pro Glu Thr Cys His Phe Ser Ser Thr 
            20                  25                  30          


Val Leu Gln Ile Ile Ser 
        35              


<210>  9604
<211>  2215
<212>  DNA
<213>  Homosapiens

<400>  9604
atgaggcagc tggcagtggg agtggaagct aagagaatgt atggggagga accaggaggt     60

ggagtccagc acaggagcaa caagccaagt actgcattca aagaaataca aacacaacca    120

gaaagtatta taagtctata ttcagcattt caaatctgtc ctgtctatca aggaaacacc    180

gaaggaggag gtaaattctt aatgcatagc agacatttaa aaattctctc tcaccattgc    240

tgcccagtca ctaccctgca tgtgaatgcc agcttgtctc ttgagttgtc tctttcctat    300

tctcaacttc cacccccaaa cacatttaga gcacaggtct tttctgtcac acttgccagt    360

cttccttgcc tgctcttatt atgtaaatca aattcaccac tctgtcctgt tttgttttca    420

tctctgcttc actcaatacc ccgactccct caggaccgtg ttgcttctgc cctgaatgag    480

ttcttttctc ccgggctgca gggaccacag aggtcttctt cctattactt catggactgt    540

atgaattcca cccagctggt gacatcatgg caggtggttt ggagatgaac tggtatcctg    600

ccctgtgtta aatgtcctca gactggagct cagaactttt gagtattttc aaaagggtca    660

ccgtgtctcc agagaaatgc tcccaacagt cctaactgaa gtcagcactg aactgggcaa    720

aggactcaag aaaaaaagtt tccttcctcc tcgatgtgtt gctcaaagca ctgcgtgaga    780

ccacacggag cagtatctaa gcattgagca acactcagaa gggcagcagg acaaatgcgt    840

agctgctaat gacccctctc ctgccaatgc tttcctccct cagccccctc tagggtcacc    900

gaacagctgt aaatacaagc tgaccaccct caaggagctg ggatggaggg aggttttctc    960

cagtctccag ttctgccttt gcacctctgt ggcctctcaa atgctcagcc agtattttga   1020

gtacacccaa cctcacccag gagatatatg tcacccagaa acatgtgctc tccagaaagt   1080

cttcctgaca tcatcggggc agtcctcctc cacctcctcc tcttcccagc aattcgttct   1140

gcaaattaat gccatccaaa caatcctcga gaactatcta ggaaaggacg aggaccaaat   1200

taccaagcct ttggatctaa tccatgtggc atcccatctg tgagctccag ggagattcaa   1260

agttggccag tgctggaggc caatcatatt tataccattt ccatatggca ccttttgatt   1320

gagacttggc aagcacatga tcggattgga ggaagacaga gagcaagacg ttggaacaag   1380

cagcaggggt ggagcctggg acacaaggtc agcacatagc aagcccttgc tttggagcag   1440

aggtggccgg tttccagggc agtgagtatt tgaggcagta attgtgatct tcagcttcac   1500

tggtgcaagt atcacctgtg agaaagcagg cattgggtgt gattaattag tatgcttctt   1560

tagcatatgg ggtgagggag ggacaggggc taatttgagc agtcagggac aaggagtcaa   1620

catcagtgtg gagtgataac gtttgtacac caagctggta aatagacatc ctagttacat   1680

atgattctat tggcattgcc tacagaggag aaaaaagtga tcaagtggtt gtggatttta   1740

tgtttgctta cctgtttttt aaaaaaaagg tgaataagga actttataaa gatgttggat   1800

tccagcatgt tagacattgt agtggattga attttgatcc ccaaaaagat atgtcccaag   1860

tcttaacctc acagtagctg tcaatgtgag cttatataga gcctttgcaa atgtattaag   1920

ttaagcatct ccagacgaga tcatcctgga ttcagtgtgg gctctaaatt caatgactgg   1980

tggtggtata agagaaagga gagagagaca aacagaccca gagacacaca gaggggaagg   2040

ccatcagaag acgaggcagc tattggagtt acgcagccag agccaaggga tgccagaagc   2100

caacagaagc tggaggagtc aaggaaggat tctcccctag aaccctggaa gggactgtgg   2160

ccctgctgac gctttctggg ctccaaaact gagtgagaat aaatttctgt tgttt        2215


<210>  9605
<211>  195
<212>  PRT
<213>  Homosapiens

<400>  9605

Met Arg Gln Leu Ala Val Gly Val Glu Ala Lys Arg Met Tyr Gly Glu 
1               5                   10                  15      


Glu Pro Gly Gly Gly Val Gln His Arg Ser Asn Lys Pro Ser Thr Ala 
            20                  25                  30          


Phe Lys Glu Ile Gln Thr Gln Pro Glu Ser Ile Ile Ser Leu Tyr Ser 
        35                  40                  45              


Ala Phe Gln Ile Cys Pro Val Tyr Gln Gly Asn Thr Glu Gly Gly Gly 
    50                  55                  60                  


Lys Phe Leu Met His Ser Arg His Leu Lys Ile Leu Ser His His Cys 
65                  70                  75                  80  


Cys Pro Val Thr Thr Leu His Val Asn Ala Ser Leu Ser Leu Glu Leu 
                85                  90                  95      


Ser Leu Ser Tyr Ser Gln Leu Pro Pro Pro Asn Thr Phe Arg Ala Gln 
            100                 105                 110         


Val Phe Ser Val Thr Leu Ala Ser Leu Pro Cys Leu Leu Leu Leu Cys 
        115                 120                 125             


Lys Ser Asn Ser Pro Leu Cys Pro Val Leu Phe Ser Ser Leu Leu His 
    130                 135                 140                 


Ser Ile Pro Arg Leu Pro Gln Asp Arg Val Ala Ser Ala Leu Asn Glu 
145                 150                 155                 160 


Phe Phe Ser Pro Gly Leu Gln Gly Pro Gln Arg Ser Ser Ser Tyr Tyr 
                165                 170                 175     


Phe Met Asp Cys Met Asn Ser Thr Gln Leu Val Thr Ser Trp Gln Val 
            180                 185                 190         


Val Trp Arg 
        195 


<210>  9606
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9606
gacttctcag gcaccaccag cagcgccacc gagagttatt attatttttt gaccaagcag     60

cacatttcct ggttcagtgg cttgagctct gtgagcagct gactagtcac cccgggtctg    120

gctcaggatc agctggtgac gctgggctgg agtctatgac ttcttccttc agattgtcat    180

gaagaagggg agttaagagg aaactggggg tcctccggaa ggcgatctga gcactcaggc    240

tgatctagag gaagagtaga agtcatactt tttttctctt gcttggtgaa ttccccagca    300

gagtctggat ccagcagtgc tgttttccct gagggaatgt ggagcagctc ggcttgagtc    360

tgttgccagc ttcaggaagg gttcagactg aaaagggggt ttgaggagaa gatgctttgg    420

ctgcctgagg tcctgcttgc gttcttagaa gtcagatcca gggagaaagt gaactgggac    480

aattgacaag ctccaagggt ctggcagaag cttcctccga gactgggcat ttcatcctcc    540

ctggaggaag atctgcctgc actgcaagtg tccccaggag gagcacatgg tgacagtgat    600

gccgctggag atggagaaga ccatcagcaa actcatgttt gactttcaga ggaactcgac    660

ctcagatgat gactcaggct gtgctttgga agagtatgcc tgggtcccgc cgggtctgaa    720

gcctgaacag gtacaccagt actatagctg tctcccagaa gagaaagtcc cttatgtcaa    780

cagtcctgga gagaaactgc gaatcaagca gctactacac cagctgccgc cacatgacaa    840

tgaggttcga tattgcaact ccctggatga ggaagagaag agggagctga agcttttcag    900

cagccagagg aaacgcgaaa acttgggccg cgggaatgtc aggcctttcc cagtcaccat    960

gacaggagct atttgtgaac agtgcggagg ccagatcaat ggtggagaca tcgctgtgtt   1020

tgcgtcacgc gctggccacg gcgtttgctg gcacccgccg tgcttcgtat gcactgtctg   1080

caatgagctc ctggtggatc tgatctactt ttaccaagat gggaagatat actgtggcag   1140

gcaccatgct gagtgcctga agccgcgctg tgctgcctgc gatgagatca tctttgcaga   1200

tgaatgcaca gaagctgagg ggcgacactg gcacatgaaa cacttttgct gcttcgagtg   1260

tgagacagtg ctgggcggcc agcgctacat catgaaggag ggaagaccct actgttgcca   1320

ctgcttcgag tccttgtatg cagaatattg tgacacctgt gcccaacata taggtatcga   1380

ccaaggtcaa atgacctatg atggccaaca ctggcatgcc actgagacct gtttctgctg   1440

tgctcactgc aagaaatccc tcctggggcg gccattcctc ccgaagcagg gccagatatt   1500

ctgctcacgg gcctgcagtg ctggggaaga ccccaatggt tctgactcct ctgattccgc   1560

cttccagaac gccagggcca aggagtcccg gcgcagtgcc aaaattggca agaacaaggg   1620

caagacggag gagcccatgc tgaaccagca cagccagctg caagtgagtt ctaaccggct   1680

gtcagccgac gtagaccccc tgtcactgca gatggacatg ctcagcctgt ccagccagac   1740

acccagcctc aaccgggacc ccatctggag gagccgggaa gagccctacc attatgggaa   1800

caagatggag cagaaccaga cccagagccc tctgcagctc ctcagccagt gcaacatcag   1860

aacttcctac agtccaggag ggcaaggggc tggggcccag cccgaaatgt ggggcaagca   1920

cttcagcaac cccaaaagga gctcgtcact ggccatgaca ggacatgctg gcagcttcat   1980

caaggaatgc cgagaagact attacccggg gaggctgaga tctcaggaga gctacagtga   2040

tatgtctagt cagagtttca gtgagacccg aggcagcatc caagtcccca aatatgagga   2100

ggaagaggaa gaggaagggg gcttgtccac tcagcagtgt cggacccgtc atcccatcag   2160

ttccctgaaa tacacagagg acatgacgcc cacagagcag acccctcggg gctccatgga   2220

atccctggcc ctgtctaatg caacaggcct ctctgctgat ggtggtgcca agcgccagga   2280

gcacctatcc cgattttcca tgcctgacct cagcaaagac tctggaatga atgtgtctga   2340

gaagctgagc aacatgggca ctcttaactc gtccatgcag ttccggagcg cagagtcagt   2400

tcgcagcctg ctctctgccc agcagtacca ggagatggag ggaaacctcc accagctcag   2460

caaccccatt ggctacagag acctgcagtc ccacggaagg atgcatcaga gctttgattt   2520

tgatggaggg atggcgggca gcaagctgcc agggcaggag ggcgtgagga tccagcccat   2580

gagtgaacgc acccggagaa gagctacttc acgcgacgac aaccgccgtt tccgacctca   2640

caggtccagg cgttcccgac gctctcgctc cgacaacgcc ctccacctgg ccagcgaacg   2700

cgaggccatc tcccggttaa aagataggcc ccctctgaga gccagggagg actatgacca   2760

atttatgcgc cagcggagct tccaggagag catggggcat gggtcccgga gggacctgta   2820

cggccagtgc cctaggactg tgtcggacct ggctttgcag aatgcctttg gggaccgctg   2880

gggaccctac ttcgccgagt atgattggtg ttccacctgc tcctcctctt cagagtctga   2940

caacgagggc tatttcctag gagaacccat cccccagcca gcgcgcctgc gatacgtcac   3000

aagcgatgag ctgctgcaca aatacagctc ctacggcctc cccaaatctt ccacattagg   3060

tggcagagga cagttgcaca gcaggaaaag acagaagagc aaaaactgta tcatttctta   3120

atatgattgg gatcagggaa tgggagaaga tgggagctaa gaatgtaaag tcagaaactt   3180

gcactgtttt aaatgttaaa gcgcttttgg gggtggctta tgggggagaa aagggaaaat   3240

gctgtcagta gatggaggca aggttacagg ttgactcaat aggtagtcac agttcttggc   3300

atgttgaata ttatttgcac atttcacttt ggaaacacag tagactctat cgaggccagg   3360

cttggtcact tccttcccat cagttctgtg ttgagttgcc atctctcaag atggtaaatt   3420

gtttcctgct cgcttttatc ctctctggtt ctcttacttt taggaccctt ttttcagtaa   3480

gtaatttgtt tattagccag gacccaagac taagttattt acatgtccat tgtaaatgca   3540

atgtaaatga gagttctgat aaaatatttt tgtattttgt aatatcaaag gaatttctat   3600

atcgtaggac tcagtgggga cttgcatgca catccaccat tgtctctgag tagtattgaa   3660

atgtggcccg gtaccacctt tttttttttt tttttttttt ctatacaaat ttgttacatg   3720

tcagtgagac ctttttcaaa ggaacatatt caatttggct ttttgtggct gaaaaaacat   3780

aactgttaga cccaaagcat tttatgctcc gttccatctt aaggagccat ccttaagtct   3840

gctcccaccc tcagtagaat ttattttcta caaagtggta gtaatttttt tttaaattgc   3900

aaatgtaatt tttgccaatt agagaaacca accggtgtca gtaaaattct gtgagaaatg   3960

ccatccctgc tgggaatgtt gaagttactt aatgttgatc tatcccttgg ggaaagtaaa   4020

agtgactgtg agtggtgcca ttgtgtgatg tcagcatgac gttgttttga atgtggcatt   4080

atgttctggt gctcatgttt cctggattgt attatctgct ttcctttacc aaggcagaca   4140

gaactgctgc cttagcctga caaccggttg tcctcaaagc aaatgaactt aagcatttgg   4200

gattgaggga cagaaggatt ctgagggggc tctgcgaggg acggtgtgtg acatgtcatg   4260

cctggagaag gaacaaggct atttgaaaac agaaggcagg tcaagggtag aagttaaagg   4320

agaatctgaa ggcaggtcag ggaaaagaag aactggaaat gaaacagagg acaggtgaca   4380

accacctcga agagctccca gagattgtag aaagagtcca gtgtaaccag cttagtaacc   4440

agagtatctg gattacccag gaaggttgag ctgctgagat ttcagtggtg caatgtcttt   4500

aaaaaaacag gctttgttgg gagggtattt ccattttgaa ctttgaggac tgttggtcag   4560

aaaatgggct caaaagtgag tttgcttaat gaagacattt aacggttgtg ctgtttatag   4620

taaaataaaa ctccctacct tgcttcagtt aaaaatgaag cacttggttt cttccatcct   4680

cctcctcccc ttaatggatt gtggcagttg aaataatcca tcggatgacc cacctgtagt   4740

gagatgtact gtcgatgtag tgcccggtgt atctcagtgg ccatctgcca tggtgaggtg   4800

agcgtgatct cttttcagta tagtagttaa cattttctag tattttttat ggagagaatg   4860

tcaaaagtgg catttcagac cccgtcccag atgggtctga ggaaaggaag gctgtaaagg   4920

acatggtaat ggcactccat tcgggatgta ttaaaataat ttgcttttca ggtattaata   4980

tgacatttgt cattgtcact gattttttta aaaaagcaat gcacatgttg gttgtggctg   5040

ttttccgcat gctatcttca tatctaaatg cttcattaat tatccgagcc tccggagaat   5100

taactctatt acgtttgtat agtaagtttg taaactgctt ggcaaactga ttaagaaata   5160

atttgcaata ccgtgctact aaagtggcag gtttctggta gaaattgtgc gagtccaatt   5220

tggagtttta agttccttga ttgatgaaac taaaaaggca attttggaaa aagagagggg   5280

gaaaagtaga tcacttatct tagcaaacgg ttgaaaatat gtctgtcctc tgtggcccca   5340

aatccagtga aagaaattct cccagtaaaa gttgcttcct aactctgttt ttctcagaat   5400

acctcttacc tttctcaaag aaagcttcaa ccaccatcat cagaaagaag gtggcctaaa   5460

aactgacaca tggccagtgc ccggaggggt ctggaggcat aagtctagat gcccagagag   5520

catccaggca ctgaactgct cagagcttga gatgaaatga catacaagct tcagggtaaa   5580

actgtctact agcaagatta cctccctcaa ttctaccatt gcagatttct tctgacccca   5640

aatgcaacct tacagagaat gctgaatgag gaaggccaat tccttacaat gatggcagaa   5700

cccccaagcg aatgccctat tgaggagaag gacatcactg tatttggaat tctgcctgct   5760

agtgatagct cacacatcac atcccagaat cccactccca atgcattatt tcctgaggca   5820

agaacttaag gtcctcacct aattcctcca tcacaaccat taactcttat tggacaagct   5880

cctcctgtga gtagggcctg tactcacttc ctcttagatc ataattccat cttcaagaga   5940

ctgatttcca gaatagtaat ctttttccag cgttctctct tctccaatgc cctggttgtt   6000

atttttccca cctctcctaa tattgatctt cttgtctttt ggttagaact gcaacttcgg   6060

agttgagttc atttcctatt gctgctcaat tcagtagcaa catagctggc ttgttcccag   6120

acccaggaag tataagtcat tgacagtttc ctgagtggct ctgccaatcc ataccaccct   6180

tggtactgtg aaaaggcttc ttggcagcca ggtggcattg aggatggtat tcagggcgct   6240

ttccttctgt catatagttg tgggatctct accaagtgtg aaggtgaatg aggtaaggga   6300

gatcagaacc atgcttcctg gtttttcata catccaagga agaagtcctg gtgtgggttg   6360

tttgacacct tctttccact ttcacctttt attttttatt ccttcctttc tacccccaac   6420

cagtcgagca aatgagcaat tttgtgtttc taatacagga tctggaagta gtgctttcta   6480

atcctcattt cctgtaggat gttcctgcac tataacaaga ttatgttttc ttccttctgc   6540

agcagctttc tgcttcttgg gtactactag ctattgttca attcaggtga ggcctgtgat   6600

gacatatatg tagcatgtgc tctgcgctcc ctgcaagctg agcagataca accaatgcat   6660

cactgtatac tcttgctgag aatgtggatg cagcctcaca gatctttgca acactccaac   6720

cagccaggac cagttgatca gaactgatct tattggtctg ataaccaatc ttatttgtga   6780

actgattcat atctgtcttt ccactcttgg ttctcttgcc gtagaacaaa aacagtttag   6840

gaagcataat tacgaacatt taggaaccaa tatgtataag taattcggag actccaattc   6900

acctgcccct cccccatccc aggttgtgga ggctcgagga agctgacttc ttaggctaaa   6960

ggacaaaaaa atctctttac ctccttggcc attttcatgt tctctgccaa ttactatagg   7020

cagtcttcat tttgcagagg tgaggtaaga cttcatctta ttcttcatgt aatcccacct   7080

tctaacaaaa aataaataaa tatttaaatt ccaaggagaa gtgttctttg tgtatttcta   7140

gcagaaaaca gatgcttaag cctaagaagg aagatccgtc catgacaaag gaaagtggaa   7200

aactgaacca gttatctgaa tacttcatgc caggacagtt gctattagca actgttttgc   7260

accttcaggg ctttaaaatg ggctctgcag acagcatttg catatgcaag actcagtagc   7320

caagcctcca ctgccaattg ttgaaggcag tttcagatcg ccaccttttg aggtacattt   7380

ctttaagcac aagagaagta gaaatggcct ttgccttgtc tccagtggtt tgtccctctg   7440

gtgcctcagc agataccaga gcttattctt atgaccattt ggaagtagtc ctcaaagtaa   7500

agatcaagaa aaaattggat tctttttcca ttttctcata atagtagcct agtcaacaca   7560

agactcccat aaaatatgac tcactattgg gagccatact attttataag cttacttcct   7620

gctgacaaaa ctagctttcc tcaaggaaat ataaaggagg ggaaagtcac atagtgttag   7680

gaaaacattc ctgtgttttg aatacgatga atccatagga tagagaaaaa tctgcttgtt   7740

ctattctgag agttctctga gatatccctt cactctgctt ggcatttggc cattgatatt   7800

caacaggtca ctgaccaagc ttttctaaat ttttcagaga gagttactta ccagtaaggt   7860

ctgttcttaa acctacctag ttgattttca tatctttcca taaagtgtca tgattctgtc   7920

atagaccctg acttaacatt gtaaggacta tgagtcctcc attttttaat taattttttt   7980

ttagcaaatt aggacttcgg caggttttcc tctcctaaac tcattctttc ctccacagga   8040

ttgctttgtc catctcctgc tttcatttca agtgcataaa caaaacctca aagggcctgg   8100

gaaggtgagg caggccagag tctgtgttct gtgttgagtg tcaagctatt tgttaagaag   8160

gtctgcaaca ggcctttggt gtgggctctg cc                                 8192


<210>  9607
<211>  844
<212>  PRT
<213>  Homosapiens

<400>  9607

Met Val Thr Val Met Pro Leu Glu Met Glu Lys Thr Ile Ser Lys Leu 
1               5                   10                  15      


Met Phe Asp Phe Gln Arg Asn Ser Thr Ser Asp Asp Asp Ser Gly Cys 
            20                  25                  30          


Ala Leu Glu Glu Tyr Ala Trp Val Pro Pro Gly Leu Lys Pro Glu Gln 
        35                  40                  45              


Val His Gln Tyr Tyr Ser Cys Leu Pro Glu Glu Lys Val Pro Tyr Val 
    50                  55                  60                  


Asn Ser Pro Gly Glu Lys Leu Arg Ile Lys Gln Leu Leu His Gln Leu 
65                  70                  75                  80  


Pro Pro His Asp Asn Glu Val Arg Tyr Cys Asn Ser Leu Asp Glu Glu 
                85                  90                  95      


Glu Lys Arg Glu Leu Lys Leu Phe Ser Ser Gln Arg Lys Arg Glu Asn 
            100                 105                 110         


Leu Gly Arg Gly Asn Val Arg Pro Phe Pro Val Thr Met Thr Gly Ala 
        115                 120                 125             


Ile Cys Glu Gln Cys Gly Gly Gln Ile Asn Gly Gly Asp Ile Ala Val 
    130                 135                 140                 


Phe Ala Ser Arg Ala Gly His Gly Val Cys Trp His Pro Pro Cys Phe 
145                 150                 155                 160 


Val Cys Thr Val Cys Asn Glu Leu Leu Val Asp Leu Ile Tyr Phe Tyr 
                165                 170                 175     


Gln Asp Gly Lys Ile Tyr Cys Gly Arg His His Ala Glu Cys Leu Lys 
            180                 185                 190         


Pro Arg Cys Ala Ala Cys Asp Glu Ile Ile Phe Ala Asp Glu Cys Thr 
        195                 200                 205             


Glu Ala Glu Gly Arg His Trp His Met Lys His Phe Cys Cys Phe Glu 
    210                 215                 220                 


Cys Glu Thr Val Leu Gly Gly Gln Arg Tyr Ile Met Lys Glu Gly Arg 
225                 230                 235                 240 


Pro Tyr Cys Cys His Cys Phe Glu Ser Leu Tyr Ala Glu Tyr Cys Asp 
                245                 250                 255     


Thr Cys Ala Gln His Ile Gly Ile Asp Gln Gly Gln Met Thr Tyr Asp 
            260                 265                 270         


Gly Gln His Trp His Ala Thr Glu Thr Cys Phe Cys Cys Ala His Cys 
        275                 280                 285             


Lys Lys Ser Leu Leu Gly Arg Pro Phe Leu Pro Lys Gln Gly Gln Ile 
    290                 295                 300                 


Phe Cys Ser Arg Ala Cys Ser Ala Gly Glu Asp Pro Asn Gly Ser Asp 
305                 310                 315                 320 


Ser Ser Asp Ser Ala Phe Gln Asn Ala Arg Ala Lys Glu Ser Arg Arg 
                325                 330                 335     


Ser Ala Lys Ile Gly Lys Asn Lys Gly Lys Thr Glu Glu Pro Met Leu 
            340                 345                 350         


Asn Gln His Ser Gln Leu Gln Val Ser Ser Asn Arg Leu Ser Ala Asp 
        355                 360                 365             


Val Asp Pro Leu Ser Leu Gln Met Asp Met Leu Ser Leu Ser Ser Gln 
    370                 375                 380                 


Thr Pro Ser Leu Asn Arg Asp Pro Ile Trp Arg Ser Arg Glu Glu Pro 
385                 390                 395                 400 


Tyr His Tyr Gly Asn Lys Met Glu Gln Asn Gln Thr Gln Ser Pro Leu 
                405                 410                 415     


Gln Leu Leu Ser Gln Cys Asn Ile Arg Thr Ser Tyr Ser Pro Gly Gly 
            420                 425                 430         


Gln Gly Ala Gly Ala Gln Pro Glu Met Trp Gly Lys His Phe Ser Asn 
        435                 440                 445             


Pro Lys Arg Ser Ser Ser Leu Ala Met Thr Gly His Ala Gly Ser Phe 
    450                 455                 460                 


Ile Lys Glu Cys Arg Glu Asp Tyr Tyr Pro Gly Arg Leu Arg Ser Gln 
465                 470                 475                 480 


Glu Ser Tyr Ser Asp Met Ser Ser Gln Ser Phe Ser Glu Thr Arg Gly 
                485                 490                 495     


Ser Ile Gln Val Pro Lys Tyr Glu Glu Glu Glu Glu Glu Glu Gly Gly 
            500                 505                 510         


Leu Ser Thr Gln Gln Cys Arg Thr Arg His Pro Ile Ser Ser Leu Lys 
        515                 520                 525             


Tyr Thr Glu Asp Met Thr Pro Thr Glu Gln Thr Pro Arg Gly Ser Met 
    530                 535                 540                 


Glu Ser Leu Ala Leu Ser Asn Ala Thr Gly Leu Ser Ala Asp Gly Gly 
545                 550                 555                 560 


Ala Lys Arg Gln Glu His Leu Ser Arg Phe Ser Met Pro Asp Leu Ser 
                565                 570                 575     


Lys Asp Ser Gly Met Asn Val Ser Glu Lys Leu Ser Asn Met Gly Thr 
            580                 585                 590         


Leu Asn Ser Ser Met Gln Phe Arg Ser Ala Glu Ser Val Arg Ser Leu 
        595                 600                 605             


Leu Ser Ala Gln Gln Tyr Gln Glu Met Glu Gly Asn Leu His Gln Leu 
    610                 615                 620                 


Ser Asn Pro Ile Gly Tyr Arg Asp Leu Gln Ser His Gly Arg Met His 
625                 630                 635                 640 


Gln Ser Phe Asp Phe Asp Gly Gly Met Ala Gly Ser Lys Leu Pro Gly 
                645                 650                 655     


Gln Glu Gly Val Arg Ile Gln Pro Met Ser Glu Arg Thr Arg Arg Arg 
            660                 665                 670         


Ala Thr Ser Arg Asp Asp Asn Arg Arg Phe Arg Pro His Arg Ser Arg 
        675                 680                 685             


Arg Ser Arg Arg Ser Arg Ser Asp Asn Ala Leu His Leu Ala Ser Glu 
    690                 695                 700                 


Arg Glu Ala Ile Ser Arg Leu Lys Asp Arg Pro Pro Leu Arg Ala Arg 
705                 710                 715                 720 


Glu Asp Tyr Asp Gln Phe Met Arg Gln Arg Ser Phe Gln Glu Ser Met 
                725                 730                 735     


Gly His Gly Ser Arg Arg Asp Leu Tyr Gly Gln Cys Pro Arg Thr Val 
            740                 745                 750         


Ser Asp Leu Ala Leu Gln Asn Ala Phe Gly Asp Arg Trp Gly Pro Tyr 
        755                 760                 765             


Phe Ala Glu Tyr Asp Trp Cys Ser Thr Cys Ser Ser Ser Ser Glu Ser 
    770                 775                 780                 


Asp Asn Glu Gly Tyr Phe Leu Gly Glu Pro Ile Pro Gln Pro Ala Arg 
785                 790                 795                 800 


Leu Arg Tyr Val Thr Ser Asp Glu Leu Leu His Lys Tyr Ser Ser Tyr 
                805                 810                 815     


Gly Leu Pro Lys Ser Ser Thr Leu Gly Gly Arg Gly Gln Leu His Ser 
            820                 825                 830         


Arg Lys Arg Gln Lys Ser Lys Asn Cys Ile Ile Ser 
        835                 840                 


<210>  9608
<211>  2506
<212>  DNA
<213>  Homosapiens

<400>  9608
cccgtcatcc catcagttcc ctgaaataca cagaggacat gacgcccaca gagcagaccc     60

ctcggggctc catggaatcc ctggccctgt ctaatgcaac aggcctctct gctgatggtg    120

gtgccaagcg ccaggagcac ctatcccgat tttccatgcc tgacctcagc aaagactctg    180

gaatgaatgt gtctgagaag ctgagcaaca tgggcactct taactcgtcc atgcagttcc    240

ggagcgcaga gtcagttcgc agcctgctct ctgcccagca gtaccaggag atggagggaa    300

acctccacca gctcagcaac cccattggct acagagacct gcagtcccac ggaaggatgc    360

atcagagctt tgattttgat ggagggatgg cgggcagcaa gctgccaggg caggagggcg    420

tgaggatcca gcccatgagt gaacgcaccc ggagaagagc tacttcacgc gacgacaacc    480

gccgtttccg acctcacagg tccaggcgtt cccgacgctc tcgctccgac aacgccctcc    540

acctggccag cgaacgcgag gccatctccc ggttaaaaga taggccccct ctgagagcca    600

gggaggacta tgaccaattt atgcgccagc ggagcttcca ggagagcatg gggcatgggt    660

cccggaggga cctgtacggc cagtgcccta ggactgtgtc ggacctggct ttgcagaatg    720

cctttgggga ccgctgggga ccctacttcg ccgagtatga ttggtgttcc acctgctcct    780

cctcttcaga gtctgacaac gagggctatt tcctaggaga acccatcccc cagccagcgc    840

gcctgcgata cgtcacaagc gatgagctgc tgcacaaata cagctcctac ggcctcccca    900

aatcttccac attaggtggc agaggacagt tgcacagcag gaaaagacag aagagcaaaa    960

actgtatcat ttcttaatat gattgggatc agggaatggg agaagatggg agctaagaat   1020

gtaaagtcag aaacttgcac tgttttaaat gttaaagcgc ttttgggggt ggcttatggg   1080

ggagaaaagg gaaaatgctg tcagtagatg gaggcaaggt tacaggttga ctcaataggt   1140

agtcacagtt cttggcatgt tgaatattat ttgcacattt cactttggaa acacagtaga   1200

ctctatcgag gccaggcttg gtcacttcct tcccatcagt tctgtgttga gttgccatct   1260

ctcaagatgg taaattgttt cctgctcgct tttatcctct ctggttctct tacttttagg   1320

accctttttt cagtaagtaa tttgtttatt agccaggacc caagactaag ttatttacat   1380

gtccattgta aatgcaatgt aaatgagagt tctgataaaa tatttttgta ttttgtaata   1440

tcaaaggaat ttctatatcg taggactcag tggggacttg catgcacatc caccattgtc   1500

tctgagtagt attgaaatgt ggcccggtac cacctttttt tttttttttt ttttttctat   1560

acaaatttgt tacatgtcag tgagaccttt ttcaaaggaa catattcaat ttggcttttt   1620

gtggctgaaa aaacataact gttagaccca aagcatttta tgctccgttc catcttaagg   1680

agccatcctt aagtctgctc ccaccctcag tagaatttat tttctacaaa gtggtagtaa   1740

ttttttttta aattgcaaat gtaatttttg ccaattagag aaaccaaccg gtgtcagtaa   1800

aattctgtga gaaatgccat ccctgctggg aatgttgaag ttacttaatg ttgatctatc   1860

ccttggggaa agtaaaagtg actgtgagtg gtgccattgt gtgatgtcag catgacgttg   1920

ttttgaatgt ggcattatgt tctggtgctc atgtttcctg gattgtatta tctgctttcc   1980

tttaccaagg cagacagaac tgctgcctta gcctgacaac cggttgtcct caaagcaaat   2040

gaacttaagc atttgggatt gagggacaga aggattctga gggggctctg cgagggacgg   2100

tgtgtgacat gtcatgcctg gagaaggaac aaggctattt gaaaacagaa ggcaggtcaa   2160

gggtagaagt taaaggagaa tctgaaggca ggtcagggaa aagaagaact ggaaatgaaa   2220

cagaggacag gtgacaacca cctcgaagag ctcccagaga ttgtagaaag agtccagtgt   2280

aaccagctta gtaaccagag tatctggatt acccaggaag gttgagctgc tgagatttca   2340

gtggtgcaat gtctttaaaa aaacaggctt tgttgggagg gtatttccat tttgaacttt   2400

gaggactgtt ggtcagaaaa tgggctcaaa agtgagtttg cttaatgaag acatttaacg   2460

gttgtgctgt ttatagtaaa ataaaactcc ctaccttgct tcagtt                  2506


<210>  9609
<211>  312
<212>  PRT
<213>  Homosapiens

<400>  9609

Met Thr Pro Thr Glu Gln Thr Pro Arg Gly Ser Met Glu Ser Leu Ala 
1               5                   10                  15      


Leu Ser Asn Ala Thr Gly Leu Ser Ala Asp Gly Gly Ala Lys Arg Gln 
            20                  25                  30          


Glu His Leu Ser Arg Phe Ser Met Pro Asp Leu Ser Lys Asp Ser Gly 
        35                  40                  45              


Met Asn Val Ser Glu Lys Leu Ser Asn Met Gly Thr Leu Asn Ser Ser 
    50                  55                  60                  


Met Gln Phe Arg Ser Ala Glu Ser Val Arg Ser Leu Leu Ser Ala Gln 
65                  70                  75                  80  


Gln Tyr Gln Glu Met Glu Gly Asn Leu His Gln Leu Ser Asn Pro Ile 
                85                  90                  95      


Gly Tyr Arg Asp Leu Gln Ser His Gly Arg Met His Gln Ser Phe Asp 
            100                 105                 110         


Phe Asp Gly Gly Met Ala Gly Ser Lys Leu Pro Gly Gln Glu Gly Val 
        115                 120                 125             


Arg Ile Gln Pro Met Ser Glu Arg Thr Arg Arg Arg Ala Thr Ser Arg 
    130                 135                 140                 


Asp Asp Asn Arg Arg Phe Arg Pro His Arg Ser Arg Arg Ser Arg Arg 
145                 150                 155                 160 


Ser Arg Ser Asp Asn Ala Leu His Leu Ala Ser Glu Arg Glu Ala Ile 
                165                 170                 175     


Ser Arg Leu Lys Asp Arg Pro Pro Leu Arg Ala Arg Glu Asp Tyr Asp 
            180                 185                 190         


Gln Phe Met Arg Gln Arg Ser Phe Gln Glu Ser Met Gly His Gly Ser 
        195                 200                 205             


Arg Arg Asp Leu Tyr Gly Gln Cys Pro Arg Thr Val Ser Asp Leu Ala 
    210                 215                 220                 


Leu Gln Asn Ala Phe Gly Asp Arg Trp Gly Pro Tyr Phe Ala Glu Tyr 
225                 230                 235                 240 


Asp Trp Cys Ser Thr Cys Ser Ser Ser Ser Glu Ser Asp Asn Glu Gly 
                245                 250                 255     


Tyr Phe Leu Gly Glu Pro Ile Pro Gln Pro Ala Arg Leu Arg Tyr Val 
            260                 265                 270         


Thr Ser Asp Glu Leu Leu His Lys Tyr Ser Ser Tyr Gly Leu Pro Lys 
        275                 280                 285             


Ser Ser Thr Leu Gly Gly Arg Gly Gln Leu His Ser Arg Lys Arg Gln 
    290                 295                 300                 


Lys Ser Lys Asn Cys Ile Ile Ser 
305                 310         


<210>  9610
<211>  623
<212>  DNA
<213>  Homosapiens

<400>  9610
ctcggcgaag tagggtcccc agcggtcccc aaaggcattc tgcaaagcca ggtccgacac     60

agtcctaggg cactggccgt acaggtccct ccgggaccca tgccccatgc tctcctggaa    120

gctccgctgg cgcataaatt ggtcatagtc ctccctggct ctcagagggg gcctatcttt    180

taaccgggag atggcctcgc gttcgctggc caggtggagg gcgttgtcgg agcgagagcg    240

tcgggaacgc ctggacctgt gaggtcggaa acggcggttg tcgtcgcgtg aagtagctct    300

tctccgggca gagctctcta aggagatgtt taagaatggg ccaggtggca aagtctcagc    360

attttccact cattacatat tgcaaggatc agcaatttgc cattcctggt catagacaac    420

atgcctttgg attgcaatgg cccattatca cccctgctac tgattattcc tgtctcctac    480

tggggcctcc aacttcctct tccgtgacaa aacctaaagc agtgttacga gcactttgca    540

aaattacttg gcaatattta ctaaagctaa atacacatat acgtatatga attataaata    600

aagccgctct gaatatcctt ggc                                            623


<210>  9611
<211>  84
<212>  PRT
<213>  Homosapiens

<400>  9611

Met Gly Gln Val Ala Lys Ser Gln His Phe Pro Leu Ile Thr Tyr Cys 
1               5                   10                  15      


Lys Asp Gln Gln Phe Ala Ile Pro Gly His Arg Gln His Ala Phe Gly 
            20                  25                  30          


Leu Gln Trp Pro Ile Ile Thr Pro Ala Thr Asp Tyr Ser Cys Leu Leu 
        35                  40                  45              


Leu Gly Pro Pro Thr Ser Ser Ser Val Thr Lys Pro Lys Ala Val Leu 
    50                  55                  60                  


Arg Ala Leu Cys Lys Ile Thr Trp Gln Tyr Leu Leu Lys Leu Asn Thr 
65                  70                  75                  80  


His Ile Arg Ile 
                


<210>  9612
<211>  402
<212>  DNA
<213>  Homosapiens

<400>  9612
tctgcgctcc ggaactgcat ggacgagtta agagtgccca tgttgctcag cttctcagac     60

acattcattc cagagtcttt gctgaggcag agctctctaa ggagatgttt aagaatgggc    120

caggtggcaa agtctcagca ttttccactc attacatatt gcaaggatca gcaatttgcc    180

attcctggtc atagacaaca tgcctttgga ttgcaatggc ccattatcac ccctgctact    240

gattattcct gtctcctact ggggcctcca acttcctctt ccgtgacaaa acctaaagca    300

gtgttacgag cactttgcaa aattacttgg caatatttac taaagctaaa tacacatata    360

cgtatatgaa ttataaataa agccgctctg aatatccttg gc                       402


<210>  9613
<211>  116
<212>  PRT
<213>  Homosapiens

<400>  9613

Met Asp Glu Leu Arg Val Pro Met Leu Leu Ser Phe Ser Asp Thr Phe 
1               5                   10                  15      


Ile Pro Glu Ser Leu Leu Arg Gln Ser Ser Leu Arg Arg Cys Leu Arg 
            20                  25                  30          


Met Gly Gln Val Ala Lys Ser Gln His Phe Pro Leu Ile Thr Tyr Cys 
        35                  40                  45              


Lys Asp Gln Gln Phe Ala Ile Pro Gly His Arg Gln His Ala Phe Gly 
    50                  55                  60                  


Leu Gln Trp Pro Ile Ile Thr Pro Ala Thr Asp Tyr Ser Cys Leu Leu 
65                  70                  75                  80  


Leu Gly Pro Pro Thr Ser Ser Ser Val Thr Lys Pro Lys Ala Val Leu 
                85                  90                  95      


Arg Ala Leu Cys Lys Ile Thr Trp Gln Tyr Leu Leu Lys Leu Asn Thr 
            100                 105                 110         


His Ile Arg Ile 
        115     


<210>  9614
<211>  798
<212>  DNA
<213>  Homosapiens

<400>  9614
tcaagaacag gctgaggcta tctatagtga tacagaagtg aaatgttttt gagagcatcc     60

tgcttgtgaa cagattccta tttccgtgag gaggtgacct cgaagaagag cagcttctat    120

tctgctggga ggtgtactgc cttctggtat caggcttctg catcccggga aagctcggga    180

taacctgagg cacccccttg aaaaacaaaa gagcttgatc agagcaggag ggtcctgttg    240

cacaagccca gcatctacta tcagtttcac ctaaatcagc tgatactgtc cccaagatgg    300

aactgtactg tcacaggtca cactccaact tgagaagcac tcctttcccc tctaactacg    360

aacagaactg gagagctact ttctggctgg gtgacttggg gaaatttgta aacctcttga    420

gatgcatcag taagatgggc ataatgacag gaaatcagca gctccaagag ggcagaaact    480

gtgctcctgt ttgctagccc tgacctcata cctggtattc agtatgcagg aagaaggttt    540

agtaaggcct aaaattcccc aaggaaagaa agcatgcctc aagactgtga atgccctcca    600

gacatttaca actcatactg atgatttagc tccctttcag tagggtcttt cctatattat    660

ttattattta tgtgctgggg cagagacatg aagaaaatgg agctgtttag aacaggagtt    720

tgcaaactgc aatggccagt gaaccaaatc cagctcaccg ctcactgcct gtttttctaa    780

ataaagttgt attggaac                                                  798


<210>  9615
<211>  66
<212>  PRT
<213>  Homosapiens

<400>  9615

Met Glu Leu Tyr Cys His Arg Ser His Ser Asn Leu Arg Ser Thr Pro 
1               5                   10                  15      


Phe Pro Ser Asn Tyr Glu Gln Asn Trp Arg Ala Thr Phe Trp Leu Gly 
            20                  25                  30          


Asp Leu Gly Lys Phe Val Asn Leu Leu Arg Cys Ile Ser Lys Met Gly 
        35                  40                  45              


Ile Met Thr Gly Asn Gln Gln Leu Gln Glu Gly Arg Asn Cys Ala Pro 
    50                  55                  60                  


Val Cys 
65      


<210>  9616
<211>  434
<212>  DNA
<213>  Homosapiens

<400>  9616
ggctgtgctt tggaagagta tgcctgggtc ccgccgggtc tgaagcctga acaggtacca     60

ttctggatgg gagcatgctg gtggtttggg tgtttcactt tgccttactg gtccttcctc    120

attccagttc tgtaggaaga gtagactttg ctgattcaga gaagtggtag ggctaaatat    180

gttgaagatg ccaggggccc cagtggaaaa tgaggaaggg aaatgaaatt gagccaggag    240

tgatccattg ctaattcatt ctgtattgtc attattaact gttaccagga aatcacttga    300

acccaggagg tggaggttgt ggtgagccga gatcgtgcca ttgcattcca gcctggatga    360

caagagcgaa actcagtctg aaagaaagag acagagagag agagaaaaga aaaagaagaa    420

agaaagaagg aaag                                                      434


<210>  9617
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  9617

Met Leu Val Val Trp Val Phe His Phe Ala Leu Leu Val Leu Pro His 
1               5                   10                  15      


Ser Ser Ser Val Gly Arg Val Asp Phe Ala Asp Ser Glu Lys Trp 
            20                  25                  30      


<210>  9618
<211>  3089
<212>  DNA
<213>  Homosapiens

<400>  9618
attttgatct cagcatgtgc tgatggagta atgaaataaa gacaacactc tgcaaatggc     60

tggatacatt aagtgagaag caacttgtaa agcacccagg aaaatatctg acacattgaa    120

gatggcagga tctgcctcag ggatctgctc aagcaacgtg ggatccccac tttttcactc    180

tgctgaatac tcgaccatat tacaaggcaa caactgttct aagctggaac tagagcatga    240

actggaatga ggaaggacca gtaaggcaaa gtgaaacacc caaaccacca gcatgctccc    300

atccagaatg gtacctgttc aggcttcaga cccggcggga cccaggcata ctcttccaaa    360

gcacagcctg agtcatcatc tgaggtcgag ttcctctgaa agtcaaacat gagtttgctg    420

atggtcttct ccatctccag cggcatcact gtcaccatgt gctcctcctg gggacacttg    480

cagtgcaggc agatcttcct gcaggcagta aaggtagaag gtgagaaaga ggaaaaaacc    540

tttttttttt tccaagagcc tgccagtcac tagcccctgg atcccaaacc ataaacacat    600

tccttggcaa tgggcatcgg gcaaaggcat cgcgagcagt gttccagaac atgactgtct    660

ttgcagaggg cgtggtacac gcatgtgaaa acagcatgaa aggtcagagg ccaccaggta    720

agcatgctaa gggtgtttac atgtggaccc cagccttctc ttctaaatca ataccccaag    780

aggaatggta atatagtttt tattttacta ggtagaccac tggatatggc ccatgaccac    840

aatttccttg actgcaatag caattaaata tacataatac atatgttgac ctgaagtgtt    900

acttgtagat ttaacaaata ctgacaacat actgctttta taaaaggttc ctaagccctg    960

gaaaatggag aaaatggttt taaaaatgca ggtaaaatgt tctttaagaa gaagagcaaa   1020

catacatatt ttttctcatg aaacgtatct ggccctaaga tctcatagga aagacaattt   1080

cacctccatt aaagatccct gtaggtttgg aattctaatt agaaacccaa attttcccta   1140

tgttggtggg gttttttata tacaagaaga tcatgcatgt gaattatttc aaaaggtagc   1200

agccaaagat aaaaatctcc caaactgaac atttctcttt taaggttacc atctgttctc   1260

ttatccatag ctacagaaat gatgaagcaa taaatatgtt gatgtcagca acacaaaagc   1320

atttctagct tccaccaata aaataaaaag agagaaaaaa agaatagagg aggaaaattt   1380

taaggaaata agttattcca tgttcactct ttttaaaatt attagtttcc gtagcacctt   1440

ataaaggtga taaaagagcc cagaatttta atccccagat gtgcctgaac gttctgataa   1500

cagctttgtg aagatacaat gtacaaacca taaaactcac catttcaaag tgtacaattc   1560

atggactctt aatacattcg gaattgtgaa tcatcactat ctaattttca tcccctcccc   1620

aaaagaaacc ccaggagcat tggcagttat ttcccatatc cctctgcccc caggctctaa   1680

caaccactaa tctattttct gtctctatgg ttttgcctat tttggacatt tcatataaat   1740

gcaatcatat aatatgtggt tcttttgaag ttggcttctt tcacacagaa tgacttttca   1800

aggttaatcc aagttatagc atgtatcaat ccttcatccc cttttattgt tgaataatat   1860

gccattgtat agatatacca cattttcatt gatcagttgt gcacatttgg actattttca   1920

cctatggctt ttatgaataa tgatgctctg attacttatg tataattttt tgtgtggata   1980

tttgttttgt tttgttttgt tttttgagac aggttctcat tgtttcccag gatggagtgc   2040

agtgatgcaa tcacggctca cagcagcctt gacctcctgg gctcaagcga tcctcctgtc   2100

ttagcctccc aagtagctgg gaccacacag gggcatgcca ccacgcctgg cttttttttt   2160

ttctgagaca gagtctcact ctgtcgccca ggctggagtg cagtggtgcc atctcagctc   2220

actgcaacct ctggccgccc aggttcaagc aattctcctg ccttggcctc ctgagtagct   2280

gggactacag gcatgcacca ccacgcccag ctaatttttg tatttttagt agagacgggg   2340

tttcaccatg ttggccaggc tggtcttgaa ctcctgacct catgatccac ccgcgtcagc   2400

ctcccaaagt gctgggatta caggcatgag ccactgccct cagtcggata tatgttttta   2460

attttttttt ttttttttga gatggagtct tgctctgtcg cccagactgg agtgcagtgg   2520

cacgatctcg gctcactgca agctccacct cctgggttcg tgccattctc atgcctcagc   2580

ctcccgagta gctgggacta caggtgcctg ccaccatgcc tagctaattt tttgtatttt   2640

tagtagagac cgggtttcac catattagcc aggatggtct tgatctcctg acctcgtgat   2700

ccgcctgcct cggcctccca aagtgctagg attacaggca tgagccacca cgcctggcca   2760

aagtttttaa ttcttttggg tatattccta gaaatgaaat tgctaggtca tgtggcaact   2820

ttagatttaa cattttgagg aactcccaaa ttgttttcac aaaatatctg tacctttgta   2880

cattcccacc actgatgaat gagtgttcca ttttctccat attcttgtca catttgttat   2940

tgtctgtctt cttttattgt agctactata gtgggtataa aacagtattt aattgtggtt   3000

ttgatttgca tttccctaac gtctaatgat gttgaatatc tttttatgtg cttattatgt   3060

atcttcttag aatagagaca tgtctatac                                     3089


<210>  9619
<211>  44
<212>  PRT
<213>  Homosapiens

<400>  9619

Met Asn Trp Asn Glu Glu Gly Pro Val Arg Gln Ser Glu Thr Pro Lys 
1               5                   10                  15      


Pro Pro Ala Cys Ser His Pro Glu Trp Tyr Leu Phe Arg Leu Gln Thr 
            20                  25                  30          


Arg Arg Asp Pro Gly Ile Leu Phe Gln Ser Thr Ala 
        35                  40                  


<210>  9620
<211>  2084
<212>  DNA
<213>  Homosapiens

<400>  9620
aggattcctc atgggatgac aaggccttgc tccagggatg atgtttccca ctgtaggaga     60

acagctactg tctttgatga actgagtcta cagggctatt gaagggtctt gctgtgctgc    120

ccagcctgga gtgtggtggt gcgatcatgg ctcactgaag cctccactta caactcctgg    180

actcaagtga tcctcccacc tgagcctcct gagtagctag gactataggc acttggcacc    240

acacctggca aatttttttt atcataggat ctcgctacat tggccaggct ggtctcaaac    300

ttctggcccc aagtgatttt cccacctctg cctcccaaag tgctgagact acagtctggc    360

ccttcatgat ctctagatat taccaaaagt cccagagaaa tgagtgcatg gatggcttaa    420

tgacaaccca ctttcttctc tggaagaaag aacttagtac agccctacca gaaggtggga    480

tggcaatgcc atcttcagac ttgagtgttg gggaggcctt ttctgctaac caacagcaaa    540

tgttttacaa gagaaacagg acacacagta gatgaaggca gccatggaaa atctgtatga    600

attatccact ctgttgatct gtgcttaaaa tatagaaggg aaagtgaaga ataaaaatgt    660

gtccatgagc atcccacctg gcttgcatcc agattgaaca atttgaatgc taagagcagg    720

attttgatag tatggcagac attgctcatt gctcagccaa cccattctcc cctttgtcct    780

tactaacaac atcctgattt tgtgtaggca acaatgctcc cagctaaaat tacctacttt    840

accagactcc tatgcagtta gaggtggccc agtaaccctg gcaaataaga tgcatgcagg    900

cattactgga ctgagcttcc aaaaacagct tttaaaaggg gcaagctcaa ctgcatgacc    960

ctttgggctt ttgaacctct ttacctggaa atgagaccta aagctaaaaa tgaaacaact   1020

gtcttgttat catgaggtga ctatcatgaa gatgaaaacc tccacaccaa ataagtggaa   1080

agaaaagttg gaaagaggtg gagagaatga ctcaatcttt gatgtatcag tgctgcattg   1140

cctccctcaa aatgtctcaa ctgttttatg cagctgagca aattcgtgat ctcaaacagc   1200

aactcaagca actccaggaa agaaaaaaaa ttgaccactg gaggagatac ctaagataat   1260

cctggtgata ctttcggtgc tacaagaaaa aaataatcct cgcacccaag aagaaacaat   1320

gaaaccttat ttttcatgta aatttctact cctgtttggt tcaagcattt gaactgttgc   1380

ataagatttt tttgagtgcc gctgagaaaa gtattatcaa tctagaatgc accagaaaga   1440

aagcagcaga aagattacaa acagcttttc taaacccttg tccagcattt accagaaaga   1500

gcagcatgaa ttaacaaaag cagaaatttt agttaaaaaa aaaaagcaac tcaactctga   1560

ttcctgagac atataataca ggacgtctat cgcccattta ccctcatcca actcaaatgg   1620

ctaccaaact ctaaaattag cagggcatgt cgggaagact tcttattcct tgtattacag   1680

atctgttgac gtgtcagtag cattttcctt tgcaagttat aaaatttcct ttccccagtc   1740

ttcaaatagg cacttccccc tccccaaagt ctcttttgtc accaactgcc ataacccacc   1800

aatcagggaa acaaatttca gttcataaaa gaaaaccatg ggtgacctac tgaggaccac   1860

agtttcattt ccataacaaa gactgacata caacccatgc ccaaagtctg gaacagctat   1920

gaataactgt ggctgaatag tctattttct gttgggattc atatcaaact ctatatttga   1980

acttgagata tcagaacttt tgtattataa tacataaaac ctaggtagtg agtttgaatt   2040

gtctgcattt attctccatg ggtaataaaa actcattgtt tctc                    2084


<210>  9621
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  9621

Met Ile Ser Arg Tyr Tyr Gln Lys Ser Gln Arg Asn Glu Cys Met Asp 
1               5                   10                  15      


Gly Leu Met Thr Thr His Phe Leu Leu Trp Lys Lys Glu Leu Ser Thr 
            20                  25                  30          


Ala Leu Pro Glu Gly Gly Met Ala Met Pro Ser Ser Asp Leu Ser Val 
        35                  40                  45              


Gly Glu Ala Phe Ser Ala Asn Gln Gln Gln Met Phe Tyr Lys Arg Asn 
    50                  55                  60                  


Arg Thr His Ser Arg 
65                  


<210>  9622
<211>  2401
<212>  DNA
<213>  Homosapiens

<400>  9622
tcccgctgct cctcctccgc ctccttcccc tgcccgcgcc cgccctactg ccccgtgccg     60

agtttcctgt ttaagatggc gtcccccgta gcagcgcagg ccgggaagct tctgcgagcc    120

ctagcgctgc ggccccgctt cctggcggcc gggtcccagg cagttcaatt aacctccaga    180

agatggctga acctgcagga ataccagagc aagaaactga tgtctgacaa cggagtgaga    240

gttcaaagat tctttgtagc agacactgca aatgaagctc tcgaggctgc taagagacta    300

aatgcaaaag aaattgtttt aaaagcccag atcttagctg gaggaagagg aaaaggtgtc    360

ttcaatagtg gtttgaaagg aggtgttcat ttaacaaaag accctaatgt tgtgggacag    420

ctggctaaac agatgattgg gtacaatcta gcgacaaaac aaactccaaa agaaggtgtg    480

aaagttaaca aggtgatggt tgctgaagcc ttggatattt ccagagaaac ctacctggca    540

attctgatgg accggtcctg caatggcccc gtgctggtgg gcagccccca ggggggcgtc    600

gacattgaag aggtggctgc ttcaaacccg gagctcattt ttaaggagca aattgacatt    660

tttgaaggaa taaaggacag ccaagctcag cggatggccg aaaatctagg cttcgttggg    720

cctttgaaaa gccaggctgc agatcaaatt acgaagctgt ataatctctt cctgaaaatt    780

gatgctactc aggtggaagt gaatcccttt ggtgaaactc cagaaggaca agttgtctgt    840

tttgatgcca agataaactt tgatgacaac gcagaattcc gacaaaaaga catatttgct    900

atggacgaca aatcagagaa tgagcccatt gaaaatgaag ctgccaaata tgatctaaaa    960

tacataggac tagatgggaa cattgcctgc tttgtgaatg gtgctgggct cgccatggct   1020

acttgtgata tcattttcct taatggtggg aagccagcca acttcttgga tcttggaggt   1080

ggtgtaaagg aagctcaagt atatcaagca ttcaaattgc tcacagctga tcctaaggtt   1140

gaagccatcc ttgtcaatat atttggtggt atcgtcaact gtgccatcat tgccaatggg   1200

atcaccaaag cctgccggga gctagaactc aaggtgcccc tggtggtccg gcttgaagga   1260

accaacgtcc aagaggccca gaagatactc aacaacagcg gactccccat tacttcagcc   1320

attgacctgg aggatgcagc caagaaggct gtggccagtg tggccaagaa gtgatgtctt   1380

tgtcctgatc caatggagaa agaaagccat ttttccgtaa aaagggatgg ttcatcattg   1440

tgaaagaaat ggttatctca ttggggaaga aaaggggagg gggaaggcaa gaatcactga   1500

aaaatcttaa atctgtgttt tctggaataa gatatctaga cagcctaaat ctgattttgg   1560

tctttataaa aataatatct tgtgttctca tacttttctg tcactgtaag cctgcccagt   1620

aggcagtgtt ttgcagactt tggggagtgg tctatgtggc caaatattgt gtgtatagac   1680

agaatttgaa atcaagtcct gcttcattta caagaatttt ggtgggcatc taatcctaca   1740

taatgaaaaa gaaaaacaga ccatttaaaa actcagacaa gattatattt aatatattaa   1800

ttactaaaaa ggcataagat tacactgaac atattagcta ctaaaaaggc actgctaaga   1860

cattcaagca aatagctatt acacactact gcagatttta caggtttcta attctaacat   1920

atgtttgaaa aatccgtgag tattccaaaa tatatttaat aatggaatat ctgcattaat   1980

ataccatcca tgtgttttta ccatttgcct taatattgaa tatactgttt acctcacact   2040

aaaaagaaaa ccagaagcct tatttgtgat tttgggagtg gaagcttcca tttttgtgtc   2100

aaaaatgaat cctgattctt atggaaatct ctgttattaa gatatttcaa gatgagacaa   2160

cactgaagat caaattgtgt ttagtatcac tatcttctct cctcgtttct ctcttactcc   2220

tcatcctccc agaatctacc agtttatggt agaaagatgg gaaccttatt tgaatgtgtt   2280

ttttttttcc atgatgtcca attttgttgt gggaaaggat ttggataaaa tttttgttta   2340

aattttggta gatttttatc tatacaaatt taaataaaat tatgttttgt aagctgtaag   2400

a                                                                   2401


<210>  9623
<211>  432
<212>  PRT
<213>  Homosapiens

<400>  9623

Met Ala Ser Pro Val Ala Ala Gln Ala Gly Lys Leu Leu Arg Ala Leu 
1               5                   10                  15      


Ala Leu Arg Pro Arg Phe Leu Ala Ala Gly Ser Gln Ala Val Gln Leu 
            20                  25                  30          


Thr Ser Arg Arg Trp Leu Asn Leu Gln Glu Tyr Gln Ser Lys Lys Leu 
        35                  40                  45              


Met Ser Asp Asn Gly Val Arg Val Gln Arg Phe Phe Val Ala Asp Thr 
    50                  55                  60                  


Ala Asn Glu Ala Leu Glu Ala Ala Lys Arg Leu Asn Ala Lys Glu Ile 
65                  70                  75                  80  


Val Leu Lys Ala Gln Ile Leu Ala Gly Gly Arg Gly Lys Gly Val Phe 
                85                  90                  95      


Asn Ser Gly Leu Lys Gly Gly Val His Leu Thr Lys Asp Pro Asn Val 
            100                 105                 110         


Val Gly Gln Leu Ala Lys Gln Met Ile Gly Tyr Asn Leu Ala Thr Lys 
        115                 120                 125             


Gln Thr Pro Lys Glu Gly Val Lys Val Asn Lys Val Met Val Ala Glu 
    130                 135                 140                 


Ala Leu Asp Ile Ser Arg Glu Thr Tyr Leu Ala Ile Leu Met Asp Arg 
145                 150                 155                 160 


Ser Cys Asn Gly Pro Val Leu Val Gly Ser Pro Gln Gly Gly Val Asp 
                165                 170                 175     


Ile Glu Glu Val Ala Ala Ser Asn Pro Glu Leu Ile Phe Lys Glu Gln 
            180                 185                 190         


Ile Asp Ile Phe Glu Gly Ile Lys Asp Ser Gln Ala Gln Arg Met Ala 
        195                 200                 205             


Glu Asn Leu Gly Phe Val Gly Pro Leu Lys Ser Gln Ala Ala Asp Gln 
    210                 215                 220                 


Ile Thr Lys Leu Tyr Asn Leu Phe Leu Lys Ile Asp Ala Thr Gln Val 
225                 230                 235                 240 


Glu Val Asn Pro Phe Gly Glu Thr Pro Glu Gly Gln Val Val Cys Phe 
                245                 250                 255     


Asp Ala Lys Ile Asn Phe Asp Asp Asn Ala Glu Phe Arg Gln Lys Asp 
            260                 265                 270         


Ile Phe Ala Met Asp Asp Lys Ser Glu Asn Glu Pro Ile Glu Asn Glu 
        275                 280                 285             


Ala Ala Lys Tyr Asp Leu Lys Tyr Ile Gly Leu Asp Gly Asn Ile Ala 
    290                 295                 300                 


Cys Phe Val Asn Gly Ala Gly Leu Ala Met Ala Thr Cys Asp Ile Ile 
305                 310                 315                 320 


Phe Leu Asn Gly Gly Lys Pro Ala Asn Phe Leu Asp Leu Gly Gly Gly 
                325                 330                 335     


Val Lys Glu Ala Gln Val Tyr Gln Ala Phe Lys Leu Leu Thr Ala Asp 
            340                 345                 350         


Pro Lys Val Glu Ala Ile Leu Val Asn Ile Phe Gly Gly Ile Val Asn 
        355                 360                 365             


Cys Ala Ile Ile Ala Asn Gly Ile Thr Lys Ala Cys Arg Glu Leu Glu 
    370                 375                 380                 


Leu Lys Val Pro Leu Val Val Arg Leu Glu Gly Thr Asn Val Gln Glu 
385                 390                 395                 400 


Ala Gln Lys Ile Leu Asn Asn Ser Gly Leu Pro Ile Thr Ser Ala Ile 
                405                 410                 415     


Asp Leu Glu Asp Ala Ala Lys Lys Ala Val Ala Ser Val Ala Lys Lys 
            420                 425                 430         


<210>  9624
<211>  7017
<212>  DNA
<213>  Homosapiens

<400>  9624
atcacagctt ggtgctgggg ctcagcatgg ccaggtggct aaccagggct tggtgtcaac     60

tacatttggg atgatgacac ttggaggaca cagagccact gtgcagcagg agtcgccact    120

gctaacagcc agagtgtccc agaagctttt gttgacaatt ccagtttccg aacaaaacat    180

ttcggcaatg gtgagggctt cgatcccttc tctgatttgc tgtcagccat gaacggatgg    240

atgtgatgcc tgctagccaa aaggcttccc tctgtgtgtt gcagtcctgt ggcattatgc    300

atgccccctc ccagtgaccc caggcttttt atggctgtga gacacgttaa aatttcaggg    360

gtaagacgtg accttttgag gtgactataa ctgaagattg ctttacagaa gccaaaaaag    420

gtttttgagt catgatgcaa gaatctggga ctgagacaaa aagtaacggt tcagccatcc    480

agaatgggtc gggcggcagc aaccacttac tagagtgcgg cggtcttcgg gaggggcggt    540

ccaacggaga gacgccggcc gtggacatcg gggcagctga cctcgcccac gcccagcagc    600

agcagcaaca ggcacttcag gtggcaagac agctccttct tcagcagcaa cagcagcagc    660

aagttagtgg attaaaatct cccaagagga atgacaaaca accagctctt caggttcccg    720

tgtcagtggc tatgatgaca cctcaagtta tcactcccca gcaaatgcag cagatcctcc    780

agcaacaagt gctgagccct cagcagctcc aggttctcct ccagcagcag caggccctca    840

tgcttcaaca gcagcagctt caagagtttt ataaaaaaca acaggaacag ttgcagcttc    900

aacttttaca acaacaacat gctggaaaac agcctaaaga gcaacagcag gtggctaccc    960

agcagttggc ttttcagcag cagcttttac agatgcagca gttacagcag cagcacctcc   1020

tgtctttgca gcgccaaggc cttctgacaa ttcagcccgg gcagcctgcc cttccccttc   1080

aacctcttgc tcaaggcatg attccaacag aactgcagca gctctggaaa gaagtgacaa   1140

gtgctcatac tgcagaagaa accacaggca acaatcacag cagtttggat ctgaccacga   1200

catgtgtctc ctcctctgca ccttccaaga cctccttaat aatgaaccca catgcctcta   1260

ccaatggaca gctctcagtc cacactccca aaagggaaag tttgtcccat gaggagcacc   1320

cccatagcca tcctctctat ggacatggtg tatgcaagtg gccaggctgt gaagcagtgt   1380

gcgaagattt ccaatcattt ctaaaacatc tcaacagtga gcatgcgctg gacgatagaa   1440

gtacagccca atgtagagta caaatgcagg ttgtacagca gttagagcta cagcttgcaa   1500

aagacaaaga acgcctgcaa gccatgatga cccacctgca tgtgaagtct acagaaccca   1560

aagccgcccc tcagcccttg aatctggtat caagtgtcac tctctccaag tccgcatcgg   1620

aggcttctcc acagagctta cctcatactc caacgacccc aaccgccccc ctgactcccg   1680

tcacccaagg cccctctgtc atcacaacca ccagcatgca cacggtggga cccatccgca   1740

ggcggtactc agacaaatac aacgtgccca tttcgtcagc agatattgcg cagaaccaag   1800

aattttataa gaacgcagaa gttagaccac catttacata tgcatcttta attaggcagg   1860

ccattctcga atctccagaa aagcagctaa cactaaatga gatctataac tggttcacac   1920

gaatgtttgc ttacttccga cgcaacgcgg ccacgtggaa gaatgcagtg cgtcataatc   1980

ttagtcttca caagtgtttt gtgcgagtag aaaacgttaa aggggcagta tggacagtgg   2040

atgaagtaga attccaaaaa cgaaggccac aaaagatcag tggtaaccct tcccttatta   2100

aaaacatgca gagcagccac gcctactgca cacctctcaa tgcagcttta caggcttcaa   2160

tggctgagaa tagtatacct ctatacacta ccgcttccat gggaaatccc actctgggca   2220

acttagccag cgcaatacgg gaagagctga acggggcaat ggagcatacc aacagcaacg   2280

agagtgacag cagtccaggc agatctccta tgcaagccgt gcatcctgta cacgtcaaag   2340

aagagcccct cgatccagag gaagctgaag ggcccctgtc cttagtgaca acagccaacc   2400

acagtccaga ttttgaccat gacagagatt acgaagatga accagtaaac gaggacatgg   2460

agtgactatc ggggcgggcc aaccccgaga atgaagattg gaaaaaggaa aaaaaaaaaa   2520

acacgtcaaa agttagcagt gaaattgttc tccatttgtt gtacagtctg gaggattttc   2580

actacgtttt gacaactctg aaatgtgtta actcttagtg ccatcaagaa ccccatttgg   2640

gagtattttt gatttttcta ctttttgttg aaaaaaggaa tttgtactct gtgcattgga   2700

tggacttgtt tggtacttgg gattttcctc tcttaaccgt caacatcagt gttgtaaatt   2760

tgctaaactg attcactttt agcagcagac tttgaactgc agtcctgcca acgttggaca   2820

ctgaggacgc ccgacagagc ttgtgcacct aagctgcaga ccaagccttt gcccagaatt   2880

taaggattcc aatggacgac ctatttgcac agtactgcat gttgattatc actgccttta   2940

ctcctttttt tttttttttt tttttttttt ttttgcttcc agttgggatg gggaaggcct   3000

ttgtgtgtgt attgggggga ggggttaaaa aataattatc ccaaactttt taatgtattg   3060

cttttttttt tttttttttt ccttctacta taccatttta agttctgacc tcaggcctcc   3120

atttgggccg atggcctctt ggaggcttaa agttttctgt accttgtgat gaatgttaat   3180

aggtgttttt attatacaaa gctgaatgtc atttctcgtt tgtagctttc tgtcactcat   3240

tccatcttcc ttcagacatc accacgtttc tctaaagtca gaaaacattc cgttttggtc   3300

tttttcaaaa aggtcccaaa tgctgcactc tacacatgaa ggccctctca cacagacgtg   3360

acgtcctgcc agaaagagaa tgaatgacag aaaaaaaaaa gagagacaaa ctctaggaac   3420

aatgccgatt cattccacgc agcagtattg ggggtggttc gggggagggg tgtttcggat   3480

tttctttttt tcttttcttt tctttttttt tttttgcagc aaccattaat aaatgccacc   3540

acattctacc agcacaagga aacataggca gcactgaaaa aaaaaaaaaa gctcatatta   3600

attagactga caatatggcc ttggaaggct ctcccttgtg gaaccaagtt gccatgggcc   3660

ttgggtgctc tgcgataacg ggtgtgggtt ggttttgttt gcaaaatggc caaaaaaaaa   3720

aaccggcttc cccgagcagc tgccctgaaa gtaggggtgg cggcggcggc gctgagttta   3780

tacattagtt cagacctact tggtggcatt aaactgtttg aatgcaaatt cgatttcaga   3840

ttgaacttgt taagggagtt aacgagggct gagttcagca aatgctaaag tgttaatttc   3900

aaatatgcaa atttggtact gcagtttgtt atgcaatatt atatcaccaa cccagtatca   3960

caaaaactca tagaagatat catgtaggcc ctgggctttg ggggggtccc aaacatggta   4020

tgcagaaatg tgatggttac aggtcagtac aacctcagtc cttagaaccc ctccacactt   4080

cagctctgca cccactttcc tgtcatttat ttatatagga ctgtagtttt ttttagttcg   4140

agagcctttc gaagcttaat ttatattctt tctttgtacc ttttttctaa aattaccaaa   4200

gatattacac aaaggtaaat tatgttctct gttttatgct ttatctgatg aagccaaata   4260

tcctcttatt gttgatcaaa ggaggcaaaa gaatttagag gcaaatgaca agcgataggc   4320

tattgcaacc tgagaaagag aactgctcct tcatcgtaaa tttagaagac caagtagata   4380

atggaaccaa agttgttact tttttctagt agttattttt cctttttctt tttgtgtacc   4440

tctacagaga ccaaaactca ttctcttaaa gagattttat ggggctactg cagataaaaa   4500

taggacacaa tattaaagga gctacagaag gaagggagtc ccatctcaaa aaaaaaatga   4560

atgtatgcca ctgcaattag agtatccaat aaaggagaca gtttagagtc aggacagaaa   4620

agcttccata attgaactag attacataat agtatttcta gaaaaagaga tatttttaga   4680

ttgtatgcca cttttgttta agaactgtgc tgtgatcact gtattaattt tggtttatct   4740

tggcatatat ccttcagttt gtttttattt ttaatttttc ctttttttcc gattaggctt   4800

tggtcagcat ttttcattta aagaaaagta acactcccat ccactcataa gcttggtaca   4860

aaaacttctc tggcagttac ttttgaagct tcactctgct ttctgtataa agggcagtct   4920

gtggtcacgc aagactttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaac   4980

ttttccaggc agcttcatga tgtgcaggca gtagccagac agggtcatgg gaagggggcc   5040

ctgtgcttct aaactgagtg gttgctggtt agtttggtat tcaaaagagg ataaaaatct   5100

ggtagattag ttcattctca gcatgtgtag ctagacatga gtaaagataa cagcatgaga   5160

aactgttagt acgcatacct cagttcaaac ctttagggaa tgattaaaat ttaaaaaaaa   5220

aacatttcac tcagttgcac ttagtcgtat gtcttgcatg cttagtctaa agactgtagc   5280

aaaaaaaaaa aaaaaagaaa aattagattt tacatatctt tgcaggtatc acagccttgc   5340

agaagaacca actgaaaaaa aaattctcag gctttacagc aagcaaactt cactatgatt   5400

tttacaattc tgattctgta tcccctgggg gttatcccag ttgcttcttt aggatggggt   5460

ttattacgtt gtacatatat cccgatgtgt ctgtgtgaat ctttgtcttt tttgggggag   5520

ggcagagggc ggttcttttt ttagatattg ttcctaaaaa ggaataaatg catacacctg   5580

tttgtcaaaa cacctttgct ttttgtgcaa ctgctttata ttaacgatac taaaaaaaaa   5640

tagctttgga aaaaaaacta ctgtatgtaa cggaattgca gaatatgctg cacatgtatt   5700

ttatttagtt atccttgctt taagaatatt ggatgacatt tcctgacatg tgggagggag   5760

aaactcccta actttttttt tctgctttta aactgtaaca tagttgaaga tttctttttt   5820

ctgttctcat tgattggagc attttgtaca ggttttgtgt gtgtgtgtgt gtgtgtgtgc   5880

gcgcgtgcgt gtgtgttaat ctgttttttg atacattcct atcccttgtg tttatcctac   5940

cactgccttc ctggctatct taaacaagtt catacatttg aaaagaaaaa aaaatgttgt   6000

ttaaaaaatg ttttctcctg ctgcagtaaa tattttgcat gatgaaattc cagggtcaca   6060

cttttccaag tttatcagtg aagtagtgat taacaatggg gagtgtcaaa actattgaac   6120

ttttgtataa aaaaaaaaaa actttacaag gtgccaagat gtaaagaaaa tctgttactt   6180

tttttttctc aaagaaaagc atacattagg gaggtagtcc cgtgtgtcag acaaatgcac   6240

tgtcaggaat gaggatccaa cctacctgtc cctagagtcc gtcttgtaag atgagttagg   6300

ctgccccttg gaccagccac aaaatggaat atcaaggctt atgtacatac gtgaagagtt   6360

accaccagtc ctgccacctt tggacagctc taacaccatc cccagcatcc agtcagacct   6420

agtaaagaaa accttggatt cttaacccaa gataggctgt aaatcactag cttttttttc   6480

ctcatgaaaa aaaatagagt taaaaaatat ttcctctctt ttccatattc cagctgaact   6540

ccgtttccaa aggcacaaag aagagtgtgc ttattcagat tttgaatctt tttggtacct   6600

tttggttaat gacatagcct cctgaaattc tggatgtctt caaagtcagt tttgcttctt   6660

tatcctgaaa atcagattta caatgctgaa ggcatttctt gggcccagtg tagctcacgc   6720

aatctctgct acccataagc cttgatgaag atgatacagt ccggactgtg agcatggtgc   6780

ttcatgtata tgtgctgcca gtaacaagaa tttttttgtt ttgttttgtt ttgttttgat   6840

aaggcataaa agaaactcat tccttgacat caactgtaat tccatcattc catgtctgcg   6900

gatacagaca ataaaaaaaa tgttgtgtag tcagtactaa ttactgacat tataagcatt   6960

ctcaaatgca ataaaaatgc tggttgttca cgctggtagt aaaagttgcc acagcct      7017


<210>  9625
<211>  677
<212>  PRT
<213>  Homosapiens

<400>  9625

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg 
    530                 535                 540                 


Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln 
545                 550                 555                 560 


Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser 
                565                 570                 575     


Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn 
            580                 585                 590         


Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly 
        595                 600                 605             


Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg 
    610                 615                 620                 


Ser Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu 
625                 630                 635                 640 


Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn 
                645                 650                 655     


His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val 
            660                 665                 670         


Asn Glu Asp Met Glu 
        675         


<210>  9626
<211>  5586
<212>  DNA
<213>  Homosapiens

<400>  9626
atcacagctt ggtgctgggg ctcagcatgg ccaggtggct aaccagggct tggtgtcaac     60

tacatttggg atgatgacac ttggaggaca cagagccact gtgcagcagg agtcgccact    120

gctaacagcc agagtgtccc agaagctttt gttgacaatt ccagtttccg aacaaaacat    180

ttcggcaatg gtgagggctt cgatcccttc tctgatttgc tgtcagccat gaacggatgg    240

atgtgatgcc tgctagccaa aaggcttccc tctgtgtgtt gcagtcctgt ggcattatgc    300

atgccccctc ccagtgaccc caggcttttt atggctgtga gacacgttaa aatttcaggg    360

gtaagacgtg accttttgag gtgactataa ctgaagattg ctttacagaa gccaaaaaag    420

gtttttgagt catgatgcaa gaatctggga ctgagacaaa aagtaacggt tcagccatcc    480

agaatgggtc gggcggcagc aaccacttac tagagtgcgg cggtcttcgg gaggggcggt    540

ccaacggaga gacgccggcc gtggacatcg gggcagctga cctcgcccac gcccagcagc    600

agcagcaaca ggcacttcag gtggcaagac agctccttct tcagcagcaa cagcagcagc    660

aagttagtgg attaaaatct cccaagagga atgacaaaca accagctctt caggttcccg    720

tgtcagtggc tatgatgaca cctcaagtta tcactcccca gcaaatgcag cagatcctcc    780

agcaacaagt gctgagccct cagcagctcc aggttctcct ccagcagcag caggccctca    840

tgcttcaaca gcagcagctt caagagtttt ataaaaaaca acaggaacag ttgcagcttc    900

aacttttaca acaacaacat gctggaaaac agcctaaaga gcaacagcag gtggctaccc    960

agcagttggc ttttcagcag cagcttttac agatgcagca gttacagcag cagcacctcc   1020

tgtctttgca gcgccaaggc cttctgacaa ttcagcccgg gcagcctgcc cttccccttc   1080

aacctcttgc tcaaggcatg attccaacag aactgcagca gctctggaaa gaagtgacaa   1140

gtgctcatac tgcagaagaa accacaggca acaatcacag cagtttggat ctgaccacga   1200

catgtgtctc ctcctctgca ccttccaaga cctccttaat aatgaaccca catgcctcta   1260

ccaatggaca gctctcagtc cacactccca aaagggaaag tttgtcccat gaggagcacc   1320

cccatagcca tcctctctat ggacatggtg tatgcaagtg gccaggctgt gaagcagtgt   1380

gcgaagattt ccaatcattt ctaaaacatc tcaacagtga gcatgcgctg gacgatagaa   1440

gtacagccca atgtagagta caaatgcagg ttgtacagca gttagagcta cagcttgcaa   1500

aagacaaaga acgcctgcaa gccatgatga cccacctgca tgtgaagtct acagaaccca   1560

aagccgcccc tcagcccttg aatctggtat caagtgtcac tctctccaag tccgcatcgg   1620

aggcttctcc acagagctta cctcatactc caacgacccc aaccgccccc ctgactcccg   1680

tcacccaagg cccctctgtc atcacaacca ccagcatgca cacggtggga cccatccgca   1740

ggcggtactc agacaaatac aacgtgccca tttcgtcagc agatattgcg cagaaccaag   1800

aattttataa gaacgcagaa gttagaccac catttacata tgcatcttta attaggcagg   1860

ccattctcga atctccagaa aagcagctaa cactaaatga gatctataac tggttcacac   1920

gaatgtttgc ttacttccga cgcaacgcgg ccacgtggaa gaatgcagtg cgtcataatc   1980

ttagtcttca caagtgtttt gtgcgagtag aaaacgttaa aggggcagta tggacagtgg   2040

atgaagtaga attccaaaaa cgaaggccac aaaagatcag tggtaaccct tcccttatta   2100

aaaacatgca gagcagccac gcctactgca cacctctcaa tgcagcttta caggcttcaa   2160

tggctgagaa tagtatacct ctatacacta ccgcttccat gggaaatccc actctgggca   2220

acttagccag cgcaatacgg gaagagctga acggggcaat ggagcatacc aacagcaacg   2280

agagtgacag cagtccaggc agatctccta tgcaagccgt gcatcctgta cacgtcaaag   2340

aagagcccct cgatccagag gaagctgaag ggcccctgtc cttagtgaca acagccaacc   2400

acagtccaga ttttgaccat gacagagatt acgaagatga accagtaaac gaggacatgg   2460

agtgactatc ggggcgggcc aaccccgaga atgaagattg gaaaaaggaa aaaaaaaaaa   2520

acacgtcaaa agttagcagt gaaattgttc tccatttgtt gtacagtctg gaggattttc   2580

actacgtttt gacaactctg aaatgtgtta actcttagtg ccatcaagaa ccccatttgg   2640

gagtattttt gatttttcta ctttttgttg aaaaaaggaa tttgtactct gtgcattgga   2700

tggacttgtt tggtacttgg gattttcctc tcttaaccgt caacatcagt gttgtaaatt   2760

tgctaaactg attcactttt agcagcagac tttgaactgc agtcctgcca acgttggaca   2820

ctgaggacgc ccgacagagc ttgtgcacct aagctgcaga ccaagccttt gcccagaatt   2880

taaggattcc aatggacgac ctatttgcac agtactgcat gttgattatc actgccttta   2940

ctcctttttt tttttttttt tttttttttt ttttgcttcc agttgggatg gggaaggcct   3000

ttgtgtgtgt attgggggga ggggttaaaa aataattatc ccaaactttt taatgtattg   3060

cttttttttt tttttttttt ccttctacta taccatttta agttctgacc tcaggcctcc   3120

atttgggccg atggcctctt ggaggcttaa agttttctgt accttgtgat gaatgttaat   3180

aggtgttttt attatacaaa gctgaatgtc atttctcgtt tgtagctttc tgtcactcat   3240

tccatcttcc ttcagacatc accacgtttc tctaaagtca gaaaacattc cgttttggtc   3300

tttttcaaaa aggtcccaaa tgctgcactc tacacatgaa ggccctctca cacagacgtg   3360

acgtcctgcc agaaagagaa tgaatgacag aaaaaaaaaa gagagacaaa ctctaggaac   3420

aatgccgatt cattccacgc agcagtattg ggggtggttc gggggagggg tgtttcggat   3480

tttctttttt tcttttcttt tctttttttt tttttgcagc aaccattaat aaatgccacc   3540

acattctacc agcacaagga aacataggca gcactgaaaa aaaaaaaaaa gctcatatta   3600

attagactga caatatggcc ttggaaggct ctcccttgtg gaaccaagtt gccatgggcc   3660

ttgggtgctc tgcgataacg ggtgtgggtt ggttttgttt gcaaaatggc caaaaaaaaa   3720

aaccggcttc cccgagcagc tgccctgaaa gtaggggtgg cggcggcggc gctgagttta   3780

tacattagtt cagacctact tggtggcatt aaactgtttg aatgcaaatt cgatttcaga   3840

ttgaacttgt taagggagtt aacgagggct gagttcagca aatgctaaag tgttaatttc   3900

aaatatgcaa atttggtact gcagtttgtt atgcaatatt atatcaccaa cccagtatca   3960

caaaaactca tagaagatat catgtaggcc ctgggctttg ggggggtccc aaacatggta   4020

tgcagaaatg tgatggttac aggtcagtac aacctcagtc cttagaaccc ctccacactt   4080

cagctctgca cccactttcc tgtcatttat ttatatagga ctgtagtttt ttttagttcg   4140

agagcctttc gaagcttaat ttatattctt tctttgtacc ttttttctaa aattaccaaa   4200

gatattacac aaaggtaaat tatgttctct gttttatgct ttatctgatg aagccaaata   4260

tcctcttatt gttgatcaaa ggaggcaaaa gaatttagag gcaaatgaca agcgataggc   4320

tattgcaacc tgagaaagag aactgctcct tcatcgtaaa tttagaagac caagtagata   4380

atggaaccaa agttgttact tttttctagt agttattttt cctttttctt tttgtgtacc   4440

tctacagaga ccaaaactca ttctcttaaa gagattttat ggggctactg cagataaaaa   4500

taggacacaa tattaaagga gctacagaag gaagggagtc ccatctcaaa aaaaaaatga   4560

atgtatgcca ctgcaattag agtatccaat aaaggagaca gtttagagtc aggacagaaa   4620

agcttccata attgaactag attacataat agtatttcta gaaaaagaga tatttttaga   4680

ttgtatgcca cttttgttta agaactgtgc tgtgatcact gtattaattt tggtttatct   4740

tggcatatat ccttcagttt gtttttattt ttaatttttc ctttttttcc gattaggctt   4800

tggtcagcat ttttcattta aagaaaagta acactcccat ccactcataa gcttggtaca   4860

aaaacttctc tggcagttac ttttgaagct tcactctgct ttctgtataa agggcagtct   4920

gtggtcacgc aagactttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaac   4980

ttttccaggc agcttcatga tgtgcaggca gtagccagac agggtcatgg gaagggggcc   5040

ctgtgcttct aaactgagtg gttgctggtt agtttggtat tcaaaagagg ataaaaatct   5100

ggtagattag ttcattctca gcatgtgtag ctagacatga gtaaagataa cagcatgaga   5160

aactgttagt acgcatacct cagttcaaac ctttagggaa tgattaaaat ttaaaaaaaa   5220

aacatttcac tcagttgcac ttagtcgtat gtcttgcatg cttagtctaa agactgtagc   5280

aaaaaaaaaa aaaaaagaaa aattagattt tacatatctt tgcaggtatc acagccttgc   5340

agaagaacca actgaaaaaa aaattctcag gctttacagc aagcaaactt cactatgatt   5400

tttacaattc tgattctgta tcccctgggg gttatcccag ttgcttcttt aggatggggt   5460

ttattacgtt gtacatatat cccgatgtgt ctgtgtgaat ctttgtcttt tttgggggag   5520

ggcagagggc ggttcttttt ttagatattg ttcctaaaaa ggaataaatg catacacctg   5580

tttgtc                                                              5586


<210>  9627
<211>  677
<212>  PRT
<213>  Homosapiens

<400>  9627

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg 
    530                 535                 540                 


Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln 
545                 550                 555                 560 


Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser 
                565                 570                 575     


Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn 
            580                 585                 590         


Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly 
        595                 600                 605             


Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg 
    610                 615                 620                 


Ser Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu 
625                 630                 635                 640 


Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn 
                645                 650                 655     


His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val 
            660                 665                 670         


Asn Glu Asp Met Glu 
        675         


<210>  9628
<211>  3078
<212>  DNA
<213>  Homosapiens

<400>  9628
atttattgtg tggcggttgc acgctgtact cgcggcggcc cggccctcgc ccgggagtgc     60

gtgtgtgcgc gcgtgtgtgc gcgagtgagt gtgtgcgcgg ggtgcgcgcg cgggcgggag    120

tgggcgcgcg cggggaaagg cccgaaaaca ccttagtttg caccgagaga ccatttgcag    180

cggaacccga aagtttgtaa gaggaagaga gcgcgcggcg agcgagcgag cgggccgggg    240

gcagcggcag cggcgccggg gaccatggtg ctgccggcgc ctcctccgcg ggcgtgaagg    300

cggcgctcct actccctccc cggactccgc ggtgtcccag aagcttttgt tgacaattcc    360

agtttccgaa caaaacattt cggcaatggt gagggcttcg atcccttctc tgatttgctg    420

tcagccatga acggatggat gtgatgcctg ctagccaaaa ggcttccctc tgtgtgttgc    480

agtcctgtgg cattatgcat gccccctccc agtgacccca ggctttttat ggctgtgaga    540

cacgttaaaa tttcaggggt aagacgtgac cttttgaggt gactataact gaagattgct    600

ttacagaagc caaaaaaggt ttttgagtca tgatgcaaga atctgggact gagacaaaaa    660

gtaacggttc agccatccag aatgggtcgg gcggcagcaa ccacttacta gagtgcggcg    720

gtcttcggga ggggcggtcc aacggagaga cgccggccgt ggacatcggg gcagctgacc    780

tcgcccacgc ccagcagcag cagcaacagg cacttcaggt ggcaagacag ctccttcttc    840

agcagcaaca gcagcagcaa gttagtggat taaaatctcc caagaggaat gacaaacaac    900

cagctcttca ggttcccgtg tcagtggcta tgatgacacc tcaagttatc actccccagc    960

aaatgcagca gatcctccag caacaagtgc tgagccctca gcagctccag gttctcctcc   1020

agcagcagca ggccctcatg cttcaacagc agcagcttca agagttttat aaaaaacaac   1080

aggaacagtt gcagcttcaa cttttacaac aacaacatgc tggaaaacag cctaaagagc   1140

aacagcaggt ggctacccag cagttggctt ttcagcagca gcttttacag atgcagcagt   1200

tacagcagca gcacctcctg tctttgcagc gccaaggcct tctgacaatt cagcccgggc   1260

agcctgccct tccccttcaa cctcttgctc aaggcatgat tccaacagaa ctgcagcagc   1320

tctggaaaga agtgacaagt gctcatactg cagaagaaac cacaggcaac aatcacagca   1380

gtttggatct gaccacgaca tgtgtctcct cctctgcacc ttccaagacc tccttaataa   1440

tgaacccaca tgcctctacc aatggacagc tctcagtcca cactcccaaa agggaaagtt   1500

tgtcccatga ggagcacccc catagccatc ctctctatgg acatggtgta tgcaagtggc   1560

caggctgtga agcagtgtgc gaagatttcc aatcatttct aaaacatctc aacagtgagc   1620

atgcgctgga cgatagaagt acagcccaat gtagagtaca aatgcaggtt gtacagcagt   1680

tagagctaca gcttgcaaaa gacaaagaac gcctgcaagc catgatgacc cacctgcatg   1740

tgaagtctac agaacccaaa gccgcccctc agcccttgaa tctggtatca agtgtcactc   1800

tctccaagtc cgcatcggag gcttctccac agagcttacc tcatactcca acgaccccaa   1860

ccgcccccct gactcccgtc acccaaggcc cctctgtcat cacaaccacc agcatgcaca   1920

cggtgggacc catccgcagg cggtactcag acaaatacaa cgtgcccatt tcgtcagcag   1980

atattgcgca gaaccaagaa ttttataaga acgcagaagt tagaccacca tttacatatg   2040

catctttaat taggcaggcc attctcgaat ctccagaaaa gcagctaaca ctaaatgaga   2100

tctataactg gttcacacga atgtttgctt acttccgacg caacgcggcc acgtggaaga   2160

atgcagtgcg tcataatctt agtcttcaca agtgttttgt gcgagtagaa aacgttaaag   2220

gggcagtatg gacagtggat gaagtagaat tccaaaaacg aaggccacaa aagatcagtg   2280

gtaacccttc ccttattaaa aacatgcaga gcagccacgc ctactgcaca cctctcaatg   2340

cagctttaca ggcttcaatg gctgagaata gtatacctct atacactacc gcttccatgg   2400

gaaatcccac tctgggcaac ttagccagcg caatacggga agagctgaac ggggcaatgg   2460

agcataccaa cagcaacgag agtgacagca gtccaggcag atctcctatg caagccgtgc   2520

atcctgtaca cgtcaaagaa gagcccctcg atccagagga agctgaaggg cccctgtcct   2580

tagtgacaac agccaaccac agtccagatt ttgaccatga cagagattac gaagatgaac   2640

cagtaaacga ggacatggag tgactatcgg ggcgggccaa ccccgagaat gaagattgga   2700

aaaaggaaaa aaaaaaaaac acgtcaaaag ttagcagtga aattgttctc catttgttgt   2760

acagtctgga ggattttcac tacgttttga caactctgaa atgtgttaac tcttagtgcc   2820

atcaagaacc ccatttggga gtatttttga tttttctact ttttgttgaa aaaaggaatt   2880

tgtactctgt gcattggatg gacttgtttg gtacttggga ttttcctctc ttaaccgtca   2940

acatcagtgt tgtaaatttg ctaaactgat tcacttttag cagcagactt tgaactgcag   3000

tcctgccaac gttggacact gaggacgccc gacagagctt gtgcacctaa gctgcagacc   3060

aagcctttgc ccagaatt                                                 3078


<210>  9629
<211>  677
<212>  PRT
<213>  Homosapiens

<400>  9629

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg 
    530                 535                 540                 


Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln 
545                 550                 555                 560 


Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser 
                565                 570                 575     


Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn 
            580                 585                 590         


Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly 
        595                 600                 605             


Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg 
    610                 615                 620                 


Ser Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu 
625                 630                 635                 640 


Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn 
                645                 650                 655     


His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val 
            660                 665                 670         


Asn Glu Asp Met Glu 
        675         


<210>  9630
<211>  2975
<212>  DNA
<213>  Homosapiens

<400>  9630
ggggggtggg cgccagcgcc ccggcgaacg gcaaagaggg agccgctccc gctcgggggg     60

ccgctggagt gcccagcggg aacccgaaag tttgtaagag gaagagagcg cgcggcgagc    120

gagcgagcgg gccgggggca gcggcagcgg cgccggggac catggtgctg ccggcgcctc    180

ctccgcgggc gtgaaggcgg cgctcctact ccctccccgg actccgcggt gtcccagaag    240

cttttgttga caattccagt ttccgaacaa aacatttcgg caatggtgag ggcttcgatc    300

ccttctctga tttgctgtca gccatgaacg gatggatgtg atgcctgcta gccaaaaggc    360

ttccctctgt gtgttgcagt cctgtggcat tatgcatgcc ccctcccagt gaccccaggc    420

tttttatggc tgtgagacac gttaaaattt caggggtaag acgtgacctt ttgaggtgac    480

tataactgaa gattgcttta cagaagccaa aaaaggtttt tgagtcatga tgcaagaatc    540

tgggactgag acaaaaagta acggttcagc catccagaat gggtcgggcg gcagcaacca    600

cttactagag tgcggcggtc ttcgggaggg gcggtccaac ggagagacgc cggccgtgga    660

catcggggca gctgacctcg cccacgccca gcagcagcag caacaggcac ttcaggtggc    720

aagacagctc cttcttcagc agcaacagca gcagcaagtt agtggattaa aatctcccaa    780

gaggaatgac aaacaaccag ctcttcaggt tcccgtgtca gtggctatga tgacacctca    840

agttatcact ccccagcaaa tgcagcagat cctccagcaa caagtgctga gccctcagca    900

gctccaggtt ctcctccagc agcagcaggc cctcatgctt caacagcagc agcttcaaga    960

gttttataaa aaacaacagg aacagttgca gcttcaactt ttacaacaac aacatgctgg   1020

aaaacagcct aaagagcaac agcaggtggc tacccagcag ttggcttttc agcagcagct   1080

tttacagatg cagcagttac agcagcagca cctcctgtct ttgcagcgcc aaggccttct   1140

gacaattcag cccgggcagc ctgcccttcc ccttcaacct cttgctcaag gcatgattcc   1200

aacagaactg cagcagctct ggaaagaagt gacaagtgct catactgcag aagaaaccac   1260

aggcaacaat cacagcagtt tggatctgac cacgacatgt gtctcctcct ctgcaccttc   1320

caagacctcc ttaataatga acccacatgc ctctaccaat ggacagctct cagtccacac   1380

tcccaaaagg gaaagtttgt cccatgagga gcacccccat agccatcctc tctatggaca   1440

tggtgtatgc aagtggccag gctgtgaagc agtgtgcgaa gatttccaat catttctaaa   1500

acatctcaac agtgagcatg cgctggacga tagaagtaca gcccaatgta gagtacaaat   1560

gcaggttgta cagcagttag agctacagct tgcaaaagac aaagaacgcc tgcaagccat   1620

gatgacccac ctgcatgtga agtctacaga acccaaagcc gcccctcagc ccttgaatct   1680

ggtatcaagt gtcactctct ccaagtccgc atcggaggct tctccacaga gcttacctca   1740

tactccaacg accccaaccg cccccctgac tcccgtcacc caaggcccct ctgtcatcac   1800

aaccaccagc atgcacacgg tgggacccat ccgcaggcgg tactcagaca aatacaacgt   1860

gcccatttcg tcagcagata ttgcgcagaa ccaagaattt tataagaacg cagaagttag   1920

accaccattt acatatgcat ctttaattag gcaggccatt ctcgaatctc cagaaaagca   1980

gctaacacta aatgagatct ataactggtt cacacgaatg tttgcttact tccgacgcaa   2040

cgcggccacg tggaagaatg cagtgcgtca taatcttagt cttcacaagt gttttgtgcg   2100

agtagaaaac gttaaagggg cagtatggac agtggatgaa gtagaattcc aaaaacgaag   2160

gccacaaaag atcagtggta acccttccct tattaaaaac atgcagagca gccacgccta   2220

ctgcacacct ctcaatgcag ctttacaggc ttcaatggct gagaatagta tacctctata   2280

cactaccgct tccatgggaa atcccactct gggcaactta gccagcgcaa tacgggaaga   2340

gctgaacggg gcaatggagc ataccaacag caacgagagt gacagcagtc caggcagatc   2400

tcctatgcaa gccgtgcatc ctgtacacgt caaagaagag cccctcgatc cagaggaagc   2460

tgaagggccc ctgtccttag tgacaacagc caaccacagt ccagattttg accatgacag   2520

agattacgaa gatgaaccag taaacgagga catggagtga ctatcggggc gggccaaccc   2580

cgagaatgaa gattggaaaa aggaaaaaaa aaaaaacacg tcaaaagtta gcagtgaaat   2640

tgttctccat ttgttgtaca gtctggagga ttttcactac gttttgacaa ctctgaaatg   2700

tgttaactct tagtgccatc aagaacccca tttgggagta tttttgattt ttctactttt   2760

tgttgaaaaa aggaatttgt actctgtgca ttggatggac ttgtttggta cttgggattt   2820

tcctctctta accgtcaaca tcagtgttgt aaatttgcta aactgattca cttttagcag   2880

cagactttga actgcagtcc tgccaacgtt ggacactgag gacgcccgac agagcttgtg   2940

cacctaagct gcagaccaag cctttgccca gaatt                              2975


<210>  9631
<211>  677
<212>  PRT
<213>  Homosapiens

<400>  9631

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg 
    530                 535                 540                 


Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln 
545                 550                 555                 560 


Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser 
                565                 570                 575     


Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn 
            580                 585                 590         


Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly 
        595                 600                 605             


Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg 
    610                 615                 620                 


Ser Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu 
625                 630                 635                 640 


Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn 
                645                 650                 655     


His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val 
            660                 665                 670         


Asn Glu Asp Met Glu 
        675         


<210>  9632
<211>  889
<212>  DNA
<213>  Homosapiens

<400>  9632
gggggtgggc gccagcgccc cggcgaacgg caaagaggga gccgctcccg ctcggggggc     60

cgctggagtg cccagcggga acccgaaagt ttgtaagagg aagagagcgc gcggcgagcg    120

agcgagcggg ccgggggcag cggcagcggc gccggggacc atggtgctgc cggcgcctcc    180

tccgcgggcg tgaaggcggc gctcctactc cctccccgga ctccgcggtg tcccagaagc    240

ttttgttgac aattccagtt tccgaacaaa acatttcggc aatggtgagg gcttcgatcc    300

cttctctgat ttgctgtcag ccatgaacgg atggatgtga tgcctgctag ccaaaaggct    360

tccctctgtg tgttgcagtc ctgtggcatt atgcatgccc cctcccagtg accccaggct    420

ttttatggct gtgagacacg ttaaaatttc aggggtaaga cgtgaccttt tgaggtgact    480

ataactgaag attgctttac agaagccaaa aaaggttttt gagtcatgat gcaagaatct    540

gggactgaga caaaaagtaa cggttcagcc atccagaatg ggtcgggcgg cagcaaccac    600

ttactagagt gcggcggtct tcgggagggg cggtccaacg gagagacgcc ggccgtggac    660

atcggggcag ctgacctcgc ccacgcccag cagcagcagc aacagtggca tctcataaac    720

catcagccct ctaggagtcc cagcagttgg cttaagagac taatttcaag cccttgggag    780

ttggaagtcc tgcaggtccc cttgtgggga gcagttgctg agacgaagat gagtggacct    840

gtgtgtcagc ctaacccttc cccattttga ataaaattat tctttggag                889


<210>  9633
<211>  114
<212>  PRT
<213>  Homosapiens

<400>  9633

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Trp His Leu Ile 
    50                  55                  60                  


Asn His Gln Pro Ser Arg Ser Pro Ser Ser Trp Leu Lys Arg Leu Ile 
65                  70                  75                  80  


Ser Ser Pro Trp Glu Leu Glu Val Leu Gln Val Pro Leu Trp Gly Ala 
                85                  90                  95      


Val Ala Glu Thr Lys Met Ser Gly Pro Val Cys Gln Pro Asn Pro Ser 
            100                 105                 110         


Pro Phe 
        


<210>  9634
<211>  607
<212>  DNA
<213>  Homosapiens

<400>  9634
aatgtagaga taagagtctc actatgttgc ccaggttgat ctcaaactcc tggtctcaag     60

agatcctccc acctcagcct cccagagtca gaacccagat cctggaactc ttcttttctt    120

cttctatacc actgcttcct tgtcctcacg agcctttctc tgcgagtcca aaattcagcc    180

acatttccta agaggcacct gtacttgtct atttcaatgc agccagaagc tgacaacggc    240

ccaggaacca ggactgcttt caggaggcgc tcagaagggc agcaaagtac cctctcaaca    300

ttagtaaaat gaaacaaaag tgtcagcctt ggcttcgcac acacttaccc gttcatgaca    360

ttgggaacag agaaggctat ggcagagtgg agcagcagca tccatgccag acagacactc    420

caaacaaggg actcaagata tgtacctccg ttatacacaa ggaggacgag gaagcgctcg    480

tttcacaggg ctggacatcc ttaggtcaca gtcatcatac ctctgtactg ctgctgagct    540

catagtcaaa ggccatccat gcctttagag atggacacat gacccatcct aggccaagca    600

ggacctc                                                              607


<210>  9635
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  9635

Met Lys Gln Lys Cys Gln Pro Trp Leu Arg Thr His Leu Pro Val His 
1               5                   10                  15      


Asp Ile Gly Asn Arg Glu Gly Tyr Gly Arg Val Glu Gln Gln His Pro 
            20                  25                  30          


Cys Gln Thr Asp Thr Pro Asn Lys Gly Leu Lys Ile Cys Thr Ser Val 
        35                  40                  45              


Ile His Lys Glu Asp Glu Glu Ala Leu Val Ser Gln Gly Trp Thr Ser 
    50                  55                  60                  


Leu Gly His Ser His His Thr Ser Val Leu Leu Leu Ser Ser 
65                  70                  75              


<210>  9636
<211>  609
<212>  DNA
<213>  Homosapiens

<400>  9636
aacccaaaag agagagagct ctaaggaatt agaagatctc tcttaataca gccaccctgc     60

taaaagttca gaaaaatcac tttcacgtaa aaatgagcaa tataaaaatt ttgaggtaaa    120

attctataca aagtgataaa aaaaaaggaa cagaataaca tcttacacaa aatgaaagca    180

tttatcagac atgtcattac ttgtctgtaa cctattactt caaaatgagc taaaagacat    240

taagaataag atatacggcc tgaaagaatt acataaatca agccacgtac agtggctcac    300

acctgtaatc ccagcacttt gggaggccga ggtgggagga tcacttgcac tcacgagttt    360

gaagccagcc agggcaagat ggcgagacgc tgtccccaca aaaaaataca aagaaatagc    420

tgggtgtggt ggtgcgtgcc tgtgatccca gctatttagg aggctgagaa atgggggaag    480

aaagaataaa cttgaaaaaa agaaaaatca ttctagaaat aagaaaatac actagaggga    540

cagatagcaa atagatacaa caaataacgc tttaaaaaaa actagaaggt taaaatgaaa    600

aacaaaatc                                                            609


<210>  9637
<211>  84
<212>  PRT
<213>  Homosapiens

<400>  9637

Met Ser Leu Leu Val Cys Asn Leu Leu Leu Gln Asn Glu Leu Lys Asp 
1               5                   10                  15      


Ile Lys Asn Lys Ile Tyr Gly Leu Lys Glu Leu His Lys Ser Ser His 
            20                  25                  30          


Val Gln Trp Leu Thr Pro Val Ile Pro Ala Leu Trp Glu Ala Glu Val 
        35                  40                  45              


Gly Gly Ser Leu Ala Leu Thr Ser Leu Lys Pro Ala Arg Ala Arg Trp 
    50                  55                  60                  


Arg Asp Ala Val Pro Thr Lys Lys Tyr Lys Glu Ile Ala Gly Cys Gly 
65                  70                  75                  80  


Gly Ala Cys Leu 
                


<210>  9638
<211>  6039
<212>  DNA
<213>  Homosapiens

<400>  9638
tgatgaagtt attaacccag ttttagactt tggtgttctg agagatgcac tatgccccat     60

tgtgtgcacg agaccagcat ttgattccag tacctcctgc cctattctga tgtttatgta    120

ggcaactttg aaaaagcaaa agttcatatt caaattctgt ccttaggaat aaagtgtcga    180

aagaaataag atattttgtt accgtcatga agcatttcag ctagagcttg ctgaaaatat    240

aaacattaga tatttgggtt aggggatttc tggctcatgg cagctgggtg aataagcaac    300

aaagtctaaa aatcttggtg ctcagagcaa tgaacaattc ctttggttgg tacacagagc    360

tcatagagga gaaaagagaa aatattagta ggttggaaag gtagctgatg taagatggag    420

aacctcaaat tcagagttaa ggagtaaaga attcagtaac attaattaat attaatatta    480

aatactaatg gcagataaca tttgctatgg gcaaggcatc aagcttagtg gttgacaatt    540

cattgtatta ttttactggt aataagcttc caaggaaggt gattcttttt tttttttttt    600

tttttgagac ggaatcttgc tttgtcaaca ggctagagtg cagtggcacc atcttggctc    660

actgtaacct ctgcctcccg ggttcaggtg attctcttgc ctcagcctcc cgagtagctg    720

ggactacagg catgcgctac cacgcccagc taattttttt gtatttttag tagagacggg    780

gtttcaccat aatggccagg atggtcttga tcttttgagg tcgtgatctg cccaccttgg    840

cctcccaaag taatgggatt acaggcatga gccaccgcac agggcgtgat tctattatta    900

tgcgtagtta acagagatga gaagactgag tcttggaaaa gtcatgtgat cttaccctgg    960

gcacgcaatg gtcagatgga gccaagattt caaattagac tctgtggctt aagaatcagc   1020

cttttgagga ctgactctat tgccagtggg cacaaccagg gatttttgag cagaggagtc   1080

tctggtcaga actgtgctct gggataattc atctgtcata tttcaaagca atgtagtgag   1140

gagcccagat aggaggaaat tgtgatgttc tgaagagcgg caactacagt ctgcagttga   1200

gtgtttgatg agattggaaa ggcagtgatg gagaggtccc aaaatcctta acgttttggg   1260

cggtacttgg tgtgaaagac agatgattgg gagaatggag ttggtattct tatcccttgc   1320

taatggaaga ggagagaggg caggctggga agggatgagc tgaggtttgg atgtggcttg   1380

aggtgcagac gttaatttca ggcagagtct tttggaaggt gatgaaatac acattgaact   1440

agaggttacg aagatagtca gggctggaga tgtggatctg aagccacaga agccagtaga   1500

aagagtgaga ctggtacatt tagagaggtg cggggaaaag aaagtggctg gagaaggaga   1560

ccacgatata aatcagtctt aggagataaa gaaaaatctt tctgcacatt ggagatgaca   1620

gatttgtagg ccatgcttca gacacatacc tatacatatt catgtttgta tacatattca   1680

tgtacatatt tatatatgta ttcctatata cattcatatg tattactgtg tgtgtttgta   1740

tatgtatctt attcatgagc atgcgctgtt ctcttatgct cacatatgta ttcttgggag   1800

cctttcccac ctcagcaagt ggggagagga agagtggggt aggcgtcagt ctctccccag   1860

agcagctgat tggggcaggt tctgctccct gctgctgcag tttgagagca gtagagggaa   1920

aatggggttt actttgtgta cgtgtggttc aggccaacac gcagaatttt atacccctca   1980

aaatgcattc ctccacagaa gcctggcaac tttaaatgct ctagtaaatg ttaggtgatt   2040

tataatacag ttttaaagaa ttcagcaaga ttaccattct attgtgaaat aagggctgac   2100

agtgtggtca gtaaatgtgt taacttttca tttgggttgg tatgtctctc ctttgcaaat   2160

ccattcatct gccgaaatgc atatgagaag cattgctttt gccaatgaag gattgcagtt   2220

aggatttttt ttttttttta cttccttttc ccgtgcccct tcttaattac taagaaggtt   2280

aacagcacac acttcagggt cactgatgtt gtgttgtgtt ctgtttttgt ttttcctgta   2340

gccaaagaaa tgctgtatta ttgctcaagt ctgttttgtg ttgttgattg aagggctgag   2400

agagtgcccg tttctttttc tttcaagata ccactaagtg atttcctttc agggttctag   2460

aaaatgtgtc accctgacaa aaattgcctt cccatgctag tagccttaag cttctacttc   2520

ttaattcctt acatggccat ttcctaaatg gttagagtta tttggaacac cttaaaatta   2580

aaaagctttc attgccaccc actccaccac tcagactgcc agtgatatga aattcacctg   2640

aaccctttac agttggtgac aattgtttta ggaaaatata tgtgataaga tgctgcaggt   2700

cctcatacca gtgtcaactc agaatgtcgt tcacatttct tctgagagtc tccaattggc   2760

cacattactg agagctttgt cataatgctt taagtcattt atcagctgag gtcactttga   2820

cttttgagat tctaataaaa ttggcttgaa cttttatctt ataccctgtg ggaattccaa   2880

tgagcatttc tggaggcttt gttttcgtgg tggatttttg ttagagaact cttgatattc   2940

cttgtttccg ttgcttttct ctcttctctc agagttagaa attagcttct ttccacaatt   3000

tccttccaca cagctcacac agaccgtgga agtttaggga gttggaggaa gtttgcatca   3060

gagaaatttg gaaggatgtt taacagcctg tttgtttgtt ggtttgtttg tttgtttgtt   3120

tgtttgtttt gctgagacgg agtcccactc tgttgcccag attgcaacgg gcgatctcag   3180

ctcactgcaa cctccacctc tgggggttca agcgattctc ctgcctcagc ctcccacata   3240

actgggacta caggcttaca ccaccatgcc tggctaattt ttttgtattt ttagtagagg   3300

cagggttaca ccacgttggc caggctggtc tgggactcct gcctcaggtg atccgcccac   3360

ctcagcctcc caaagtgctg ggattacagg cgtgagccac cgcgcccgcc agccttgtat   3420

gtttgcacat acatagttgt ctctgaagag ctttctctat acatcatgac ctccaaattg   3480

cctgacttac cctcttttat ctatcttctc acctctcatt cttctggttt ctgttaccaa   3540

ctcatgtttc ttaaaaacgg caatttagtt ttctctttct gtctcaccat ttccttccaa   3600

accaggttca agggggcctg gtcttccatg tttcaagcga tgtgtcaagg atgagctgac   3660

tagtaaaatg atctttttag ttaagtacat gtgcacagac acccctgctt tttctccctc   3720

cactctctct cccataaatg tagcaaaaac tgaagctact ttgcatagaa aaagacatat   3780

taaggtttta cctattttga ctggacctgc caccctctat tcttttcatg tatttccctt   3840

taatcaaata ggttgattca aagtgcatgc cctaaatacc aacattttct cattgatact   3900

tattttctga tactagacca acaatgtctg ccctaaatcc tagggcccaa aaccaaaatc   3960

tcagcctcac agcattttat tgttgccatt ggttatgcag tcttccttgt aaagtttgac   4020

actttatatg tcattcttta atcgagtctt ctctgataat gaattcttcc ccttccccta   4080

gaaattaagg atgccaaaga aagggtaaag tggtgctgtt tgatgcagag ctagcggaaa   4140

gcatttgctg ttagagagcc acctggagct ggcccatctt ctcatgtcag tttaccataa   4200

taatgtcagc cagcatgggt atctcataat tagatgagga acatcaggca gtttcctgat   4260

ggtgttatct ttcatagttt tcacagtgat gttcctgact tggtgttaca aaaactctga   4320

aaaacatcta ccaagcttga agtgcaccct tattggttat ttttcaagtt ctcataccca   4380

cacctaaata tgtaagatgt atttctcatc agaacagtgg ctcccaaggc ctgggatccc   4440

caaaccccag gagatgccgt caaaggatta gaagatgcca tccaaggatt agaagatgcc   4500

gtcaaaggat tagaagatgt tatcctggtg tttttcagta tttaaattag gatgagtttg   4560

attgtactca acagaaagtc cagtaaaggc aggcttaaag agtgtcactg gcaagtcctt   4620

agtaggtagg ctgcaggaga gacttgatcc agctctctgc tctgcttttc atggtgttgg   4680

cttatcttca gagtggccct atttgcagtc ttaagatgat tcctagcaac tgtcaagctg   4740

tagatttcct tgcacatgtg aagcaggaga gtggaaaagg gaatattttc ttaggatttt   4800

cagaaaaatt cttgaaactc tagttggact tgtttctgcc acataccacc ctccctgtgg   4860

ccagggagat ggaatatatt agttggcatg ttttaggcca tgtgttttcc gccactggag   4920

ctggggtgca atcaacttct gcaaaatccc atgacttccc atatgtcagt tggtcccgtt   4980

tggaagtagt ttagaggaca agatgctggg gacacagcct taaatggtta tttcattgac   5040

ctgttttttt ttcctcccca ccttttttct tgttttggag acaggtccct gtcgcccatg   5100

ttggagtgca ggggtgccat catggctcag tgctgcctct acctcctggg ctcaagcaat   5160

tctcccacct ccgcttccca aatatttggg aggctgaggt aggcggctca cttgaacccg   5220

aggaggttga ggccgcagtg agctgtgatc gtgccactgc actccagcct gggtgacata   5280

gcaagaccct gtctcaaaaa aaaaaaaaaa aaaaaaaagg ccaggcgcag tggctcacgc   5340

ctgtaatcct agcactttgg gaggccgagg agggcggatc acgaggtcag gagatcgaga   5400

ccacgataaa accccgtctc tactaaaaat gcaaaaaatt agccgggcgc ggtggcaggc   5460

gcctgtagtt ccagctactg gggaggctga ggcaggagaa tggcgtgaac ccgggaggcg   5520

gagcttgcag tgagccgaga tcacatcact gaactccagc ctgggcgaca gagcaagact   5580

ccatctcaaa aaaaaaaaaa aagagagaac ctcatgtctc aggtttctga gtcaatagca   5640

gataaaacta attgtaattt acctaagaag gtaagaaggg acgaccaggt caaatgttgt   5700

gcagatgtgg ataaaagaaa aaaggacatt catttgtgct actcttattt ccaaaatttt   5760

aaattcaatg tttcaagtcc ctttttttcc agatatggta agttttacgt tttactagca   5820

tgttttaaaa acattaatca tatggaaaga aaaagatgat acattttaac actactacga   5880

tagcgtctat gactcaacaa cagaaattgt tgttagcaga accagcaaaa aaccattctg   5940

tcttggggga aaattgtttg gttgaaaggc cacagaagag atgcatattc agtaagagta   6000

atgagaggca aacacaatac cataagattg ttttgcaaa                          6039


<210>  9639
<211>  57
<212>  PRT
<213>  Homosapiens

<400>  9639

Met Val Ile Ser Leu Thr Cys Phe Phe Phe Leu Pro Thr Phe Phe Leu 
1               5                   10                  15      


Val Leu Glu Thr Gly Pro Cys Arg Pro Cys Trp Ser Ala Gly Val Pro 
            20                  25                  30          


Ser Trp Leu Ser Ala Ala Ser Thr Ser Trp Ala Gln Ala Ile Leu Pro 
        35                  40                  45              


Pro Pro Leu Pro Lys Tyr Leu Gly Gly 
    50                  55          


<210>  9640
<211>  446
<212>  DNA
<213>  Homosapiens

<400>  9640
acccaaaaca gccaaccagt atggaactgg ctaaataaat gacacttcat ccatatgaca     60

caatgctgcg ctgccattac aaagaatgat acatacctac attaatgata gagcagaatg    120

gcacacacac acagacatgc ccacacacac atatacacac atactgtact tttactactt    180

gtttaatttc tgtctttttg tccgtcacta aacctccccc caccctgcaa aattttatta    240

taaaaatgtt caaacatcca gacaagttga aaagacaaca tatttaacac ccatatacct    300

gcctcttaga taagccaaat agcaagatgc cctccccccg acctggcact ttcaaaaaac    360

agcccttctc cataggcact gccaagaagc aagctggcct ctgctctacc cttttcaccc    420

ccaaggtgag gggatgactg aagaca                                         446


<210>  9641
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  9641

Met Ile Glu Gln Asn Gly Thr His Thr Gln Thr Cys Pro His Thr His 
1               5                   10                  15      


Ile His Thr Tyr Cys Thr Phe Thr Thr Cys Leu Ile Ser Val Phe Leu 
            20                  25                  30          


Ser Val Thr Lys Pro Pro Pro Thr Leu Gln Asn Phe Ile Ile Lys Met 
        35                  40                  45              


Phe Lys His Pro Asp Lys Leu Lys Arg Gln His Ile 
    50                  55                  60  


<210>  9642
<211>  299
<212>  DNA
<213>  Homosapiens

<400>  9642
gtctcaaata ttcccaccaa aatatacctc catggcaatc ggggaaaggg agagggtggt     60

aaatgtcaac ccatgagaaa ggaagggtct ggaggcacaa atcaaagggg acctaagtag    120

gcaggaagta tcactgaaaa ccttcaaaat cttgcattat acaacagcat taatttggcc    180

atttaaaatg taaaaatggg ccaggcgcag tgactcacgc ctgtaatccc agctactcag    240

gaggctgaag taggagaatc gattgaaccc gggaggcgga ggttgcagtg agctgagat     299


<210>  9643
<211>  564
<212>  DNA
<213>  Homosapiens

<400>  9643
ctccgcgggt aagtcgaggc ggccgcgggc gcggggtcca gggacaccgg agagccccag     60

gcggcactag gggttctccg tccccaaaga gccagccggg gtggcgcgag cctagcgata    120

aggcaccggg agcgaggaat gtgcccatcc tcaggccgtg tcccagaagc ttttgttgac    180

aattccagtt tccgaacaaa acatttcggc aatggtgagg gcttcgatcc cttctctgat    240

ttgctgtcag ccatgaacgg atggatgtga tgcctgctag ccaaaagggt gagtgaatga    300

atgtttgtga ttattcatct gaaaattcac aagacaaaaa gtccttcaag acagttgccc    360

acccaggatg agagattctt atcttgaaag aagggacaaa ctctgtcatt gttttctggt    420

gtaatctttt cagataattc ctgcggtgat ctgaggattt ataaaaggca taataggaca    480

taggataact tcctctgttg gcttgtttgt tttaatcata ctctgaagga tggactatct    540

cagttttggt ccatgtgcaa cgtt                                           564


<210>  9644
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  9644

Met Cys Pro Ser Ser Gly Arg Val Pro Glu Ala Phe Val Asp Asn Ser 
1               5                   10                  15      


Ser Phe Arg Thr Lys His Phe Gly Asn Gly Glu Gly Phe Asp Pro Phe 
            20                  25                  30          


Ser Asp Leu Leu Ser Ala Met Asn Gly Trp Met 
        35                  40              


<210>  9645
<211>  230
<212>  DNA
<213>  Homosapiens

<400>  9645
cacacaatcc accttcacgt ttctgaactc ggtgtctttt acatcatcta agactcatat     60

tgtggtaccc agtgccctga aaaccctggt atccctcaag atggccttgt cttttctact    120

gacttcctgt tcaagctctt tggtttcttt cgcagagtga gatcagcaag gcagggtctg    180

ggatttgcag gttatatcct ggatggtggc acgacagcgc cttccgttcc               230


<210>  9646
<211>  58
<212>  PRT
<213>  Homosapiens

<400>  9646

Asp Ser Tyr Cys Gly Thr Gln Cys Pro Glu Asn Pro Gly Ile Pro Gln 
1               5                   10                  15      


Asp Gly Leu Val Phe Ser Thr Asp Phe Leu Phe Lys Leu Phe Gly Phe 
            20                  25                  30          


Phe Arg Arg Val Arg Ser Ala Arg Gln Gly Leu Gly Phe Ala Gly Tyr 
        35                  40                  45              


Ile Leu Asp Gly Gly Thr Thr Ala Pro Ser 
    50                  55              


<210>  9647
<211>  599
<212>  DNA
<213>  Homosapiens

<400>  9647
agaccaatat tagcaacaag aagcctctgc caccatggaa gaaggatctg gaaagaagga     60

tgggatctca gcctgatggc aggtcttacc caagagggaa tttttttctc aggagagtga    120

agaaagcctg gctttcctca tcagctctct ttgtgttgaa ttcatcagtc atgacaatca    180

tttgagaaac cttagaagat catcccaaac ctggaaaaag tcagttacat taggaaagga    240

gtgagcataa agagcaccta ctagagagag ggtcctttca cacacatgac ctcatgtaac    300

cttcacaatc atgccatgag agtatttaca gcctctgctg ttgctctgct tctatctggt    360

ggattaagga aagtcacaac tcacagccct agtggaaagt tacaactggg atttgagcta    420

acgaagagtt gaagactcag caacaggcgc ttggcttcac tattaacctg gacaaggcca    480

ttaactcgcc tgtacttaat tggcttgttc tgtgacacac tgttgcccca gaaacaccca    540

tatgggtgta ccccacatta aagaagcccg ctctatgaaa accgagactt gttgaaaag     599


<210>  9648
<211>  48
<212>  PRT
<213>  Homosapiens

<400>  9648

Met Thr Ser Cys Asn Leu His Asn His Ala Met Arg Val Phe Thr Ala 
1               5                   10                  15      


Ser Ala Val Ala Leu Leu Leu Ser Gly Gly Leu Arg Lys Val Thr Thr 
            20                  25                  30          


His Ser Pro Ser Gly Lys Leu Gln Leu Gly Phe Glu Leu Thr Lys Ser 
        35                  40                  45              


<210>  9649
<211>  371
<212>  DNA
<213>  Homosapiens

<400>  9649
aggaaatccg actggaggga acacacgctg cgatgcaccc tctcctcttc cattgagcca     60

ggggtgacct tgagagactc aggccacctc accaggctct accaggaaca gcgtctacag    120

ctggtagaga gcacgggctg cagagagatg gtaacaagaa agtaggtagc tgcaggggct    180

gctggcagcc atcttgagac atgaaaggtg tccaaattgg gatgaattca gcactgaaga    240

tggtggtaca gagaaacagg agatagggcc tttgatcaca ttgttggatg gctggttaag    300

cctctcctga aatccattct actgctggac tttacagttc ataaactaat aaatcctctt    360

tactgtttga a                                                         371


<210>  9650
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  9650

Ala Arg Gly Asp Leu Glu Arg Leu Arg Pro Pro His Gln Ala Leu Pro 
1               5                   10                  15      


Gly Thr Ala Ser Thr Ala Gly Arg Glu His Gly Leu Gln Arg Asp Gly 
            20                  25                  30          


Asn Lys Lys Val Gly Ser Cys Arg Gly Cys Trp Gln Pro Ser 
        35                  40                  45      


<210>  9651
<211>  1605
<212>  DNA
<213>  Homosapiens

<400>  9651
gtctcacgcc cataatccca gcactttggg agaccaagat ccaaaaagtt ggcagctctt     60

gcagaagcct taaaggaagt ctcccttaca aaggcccagc tggggttaga actggaagaa    120

ctagaagcag cagcactgct tgtccaggag gaagaaactg cattaaaagc agcccattca    180

gtttctgggc agcagacact ttgctccagc tctgaggcaa gtgattcgga ggactcagac    240

agcagcgtgt catctggaaa cgaagactca ggctcagatt cagaacaaga tgaactcaaa    300

gatagtccat ctgagacagt cagttctttg caaggtccct ttcttgaaga aagcagtgcc    360

tttcttattg ttgatggtgg agtacgcaga aacacagcca tccaggagtc tgatgccagt    420

cagggaaagc cacttgcctc ttcctggcct cttggagtgt ctgggcctct gatagaggag    480

cttggggaac aactgaagac tacagttcag gtttctgaac ccaagggcac cactgctgta    540

aaccgcagca atattcagga gagagacggc tgtcagacac caaataattg actcttaggt    600

ggttttattc attgttgaga aatatggtag attgggtttc atttaccgaa tgagaattct    660

tcattttcac tttgtaattt ttcttagtat atagtcagcc cactgtattt gtgtgttcca    720

catctgtgga ttcaaccaac tgcagatcaa aaatattgaa gaaaaaatcg catctgtacc    780

aaacatgtac agactttttt cttgttatta ttctctaaat aatacagtat gacaactatt    840

tccacagcat ttacattgta ttgggtaata taagtaatct agtgatgatt taaactgtgc    900

aggaggatgt gggtaggtta tatgcaaata ctgcaccatt ttttatcagg ggcttgagca    960

tctgaggatt ttagtatcct caggagtcct ggaaccaacc ccccacagat acggggacaa   1020

ctttatgaca ttgtttttca accaatgaat gtttatacct tttgttttcc ttgccgcgac   1080

tgtgaagata aagttcaaaa gtatttttac caaagtgtag ctaatatttc aagctgaaaa   1140

taatagttct actgcccgtg tctccagaat gtagagccca tcaatatttt tattttagga   1200

ggtgtacttg acacccaata aactgcacgt atcaaaagtg tacaatgtgt tggcgtatgt   1260

ataccctgcg taaaactatc accacaactg aagtgaggaa cggacccatc attcccaagt   1320

gcccttgtgc cctgttatta gtttgcatgt cctagaattc tatgtaaatt gaatcataca   1380

atatgtatcc cttttttggt caggcatatt ttactcagta tagttatttt gagattcatc   1440

catgtggtag catgtgtcac gagtttttgt ttttatgttt ttcattgctg agtactgctt   1500

cattgaatag atttgttcat tgacctatcg atggacacct gggttgtttc cagtttgggg   1560

ctgttataaa taaagctgtt atgaacattt gtgtacaagt cttca                   1605


<210>  9652
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  9652

Met Asn Ser Lys Ile Val His Leu Arg Gln Ser Val Leu Cys Lys Val 
1               5                   10                  15      


Pro Phe Leu Lys Lys Ala Val Pro Phe Leu Leu Leu Met Val Glu Tyr 
            20                  25                  30          


Ala Glu Thr Gln Pro Ser Arg Ser Leu Met Pro Val Arg Glu Ser His 
        35                  40                  45              


Leu Pro Leu Pro Gly Leu Leu Glu Cys Leu Gly Leu 
    50                  55                  60  


<210>  9653
<211>  4031
<212>  DNA
<213>  Homosapiens

<400>  9653
gaaattagtt ggcctatgct tactgtgaca tttgtcttct ctgtggcaat taaaacttca     60

aaacattctt acaggtcagt tgttccttga ttctttgggt aacatggcta gtgtggcaaa    120

catggtttca tcatgcctgc aaattttgat tatatttcct cctcctttca tcaaaccctg    180

ctctcaacat tacctagttt gtaattaaaa taggcttgtg ctggggtgat ccacactaat    240

catttgacat agttaacctg tgccactttg ataagccata gcactgacct tgccttaacc    300

aaatgaactt gacatcttgt agctttaggc cttctaagtg ttagtttctc ttcacagtca    360

gtctagcagt ggagctttca ttgacattct tcattcattc tttattgtat ctgcatatga    420

ggaagccaca aagttaatat tttttaaaaa ggtatggact ctgttttcag acttactacc    480

tacttagggg ttaaagtcag taataagtcc ttgagtaata aaaacgttgt gatatagact    540

ggatgaggca agaacataca ggtagcatgg cacagtgggt agcctctgga gccattaaga    600

ttggaattta gatcttggtc cctcaactca gtggccctgt atcttaccca tcctgaagcc    660

tccagttttc cttctgggaa ttgaacagga gaggttatgg ggaggacttt ccccattttg    720

agtttccttt ccacttcttg gcagcattat agtaaaggac cgtgaagact aggaaagtca    780

gcccagaact tcccgaagga atgaagactg gagctagacc ttgatagtgg gctaggtcac    840

atggagaagg gaaaaaggca tggaaacaag tctgtagaaa gagcattgag aacatatgca    900

gggaagagac tccatgaaag cagtgcatta aaaaatgtgt gtttgaaggg gtagagtctg    960

gaatctgaaa gatgggaaag aggattctta aaatcgaggc atgagatgag aatatgagtg   1020

aacataggag ctcaggcaat ggcatagaaa gggcagatac aaggagcatc tccaaggaaa   1080

aatcatcagg atttgacggg tgagaccgta gaatgaaaga aattttcaag gtttaagctg   1140

ggtgattact gtgtctatca tgtattcatt cattcttaga acacttaaat ggaaaacctg   1200

ctgttgcggt gttctgttct aggtattggg gattaaccac taaataaaac agaagcccct   1260

gctcttttga aacttacttt ctagtgttaa ttatgttaaa aaatttagtg tcagcaattt   1320

taggatcttg agatgtcatc atctagctca tgattctttt atgatctaaa agttaaatgg   1380

gaaatgtcaa tgaaagtgca tccagtatct tcatgaactc agtatacagt atttccgcgt   1440

ttcagaactg taaagataag aatgaaactg ttaaactgaa aatactgaat ttcacagatc   1500

aaagaaaatg gtactactct agatgtagaa ttaatagttc accttataat taataaattt   1560

caggaaatat catgaagttt ggaacaccta gggaattgct gagttgtaaa aggctccttt   1620

tgtagacttt ggttgggtta aaactaggtt catttaaaaa ccaggaggaa gtagttaggt   1680

tgaacaaggc tttaatactt gatggctttt gttcatgtga gttttgtcag cttatttctg   1740

aagtagtgct atgatgtttt agtgttcagt tttcttcaat tctttaaggt aaaataattt   1800

gttattagta gataactcct tgacagaaaa tgttgacata agaaataaag aagtttgaaa   1860

tttagaatac agttttccat gttatgttga aagcttgaat tggaagaaca ttatctaata   1920

aaaattatga tgcatttaga tattcatttg gtttagaaaa ctttcctgcc tttcatttaa   1980

ttgacctagt tgtatttcat agcattttaa tgataaccac aactagtcag ctgtaacaac   2040

agaatataaa gattatatgt aattcttttt tttttttttt tttcgagatg gagtctttct   2100

ctgtcgccca ggctggagtg cagtggcgcg atcttggctc acggcaagct ccacctcccc   2160

agttcacgcc gttctcctgc ctcagcctcc cgagtagctg ggactatagg tgcctgtcac   2220

cacgcctggc taattttttg tatttttagt agagacaggg tttcaccgtg ttagccagga   2280

tggtctcgat ctcctgacct cgtgatctgc ccgcctcggc ctcccaaagt gctggaatta   2340

caggtaaaag tgcagtttta aagtgtctcc tggatattca caaaattttt caggaaaatg   2400

acccagcgta catactgaat gatctctaca tctcagacta ctgtgtgtgg attcagaaag   2460

tcaaatccaa aaagttggca gctcttgcag aagccttaaa ggaagtctcc cttacaaagg   2520

cccagctggg gttagaactg gaagaactag aagcagcagc actgcttgtc caggaggaag   2580

aaactgcatt aaaagcagcc cattcagttt ctgggcagca gacactttgc tccagctctg   2640

aggcaagtga ttcggaggac tcagacagca gcgtgtcatc tggaaacgaa gactcaggct   2700

cagattcaga acaagatgaa ctcaaagata gtccatctga gacagtcagt tctttgcaag   2760

gtccctttct tgaagaaagc agtgcctttc ttattgttga tggtggagta cgcagaaaca   2820

cagccatcca ggagtctgat gccagtcagg gaaagccact tgcctcttcc tggcctcttg   2880

gagtgtctgg gcctctgata gaggagcttg gggaacaact gaagactaca gttcaggttt   2940

ctgaacccaa gggcaccact gctgtaaacc gcagcaatat tcaggagaga gacggctgtc   3000

agacaccaaa taattgactc ttaggtggtt ttattcattg ttgagaaata tggtagattg   3060

ggtttcattt accgaatgag aattcttcat tttcactttg taatttttct tagtatatag   3120

tcagcccact gtatttgtgt gttccacatc tgtggattca accaactgca gatcaaaaat   3180

attgaagaaa aaatcgcatc tgtaccaaac atgtacagac ttttttcttg ttattattct   3240

ctaaataata cagtatgaca actatttcca cagcatttac attgtattgg gtaatataag   3300

taatctagtg atgatttaaa ctgtgcagga ggatgtgggt aggttatatg caaatactgc   3360

accatttttt atcaggggct tgagcatctg aggattttag tatcctcagg agtcctggaa   3420

ccaacccccc acagatacgg ggacaacttt atgacattgt ttttcaacca atgaatgttt   3480

ataccttttg ttttccttgc cgcgactgtg aagataaagt tcaaaagtat ttttaccaaa   3540

gtgtagctaa tatttcaagc tgaaaataat agttctactg cccgtgtctc cagaatgtag   3600

agcccatcaa tatttttatt ttaggaggtg tacttgacac ccaataaact gcacgtatca   3660

aaagtgtaca atgtgttggc gtatgtatac cctgcgtaaa actatcacca caactgaagt   3720

gaggaacgga cccatcattc ccaagtgccc ttgtgccctg ttattagttt gcatgtccta   3780

gaattctatg taaattgaat catacaatat gtatcccttt tttggtcagg catattttac   3840

tcagtatagt tattttgaga ttcatccatg tggtagcatg tgtcacgagt ttttgttttt   3900

atgtttttca ttgctgagta ctgcttcatt gaatagattt gttcattgac ctatcgatgg   3960

acacctgggt tgtttccagt ttggggctgt tataaataaa gctgttatga acatttgtgt   4020

acaagtcttc a                                                        4031


<210>  9654
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  9654

Met Asn Ser Lys Ile Val His Leu Arg Gln Ser Val Leu Cys Lys Val 
1               5                   10                  15      


Pro Phe Leu Lys Lys Ala Val Pro Phe Leu Leu Leu Met Val Glu Tyr 
            20                  25                  30          


Ala Glu Thr Gln Pro Ser Arg Ser Leu Met Pro Val Arg Glu Ser His 
        35                  40                  45              


Leu Pro Leu Pro Gly Leu Leu Glu Cys Leu Gly Leu 
    50                  55                  60  


<210>  9655
<211>  2863
<212>  DNA
<213>  Homosapiens

<400>  9655
gaagctccgt ccctcacacc gagagttcct gcgcgtgggg agttggagag tttgcgtggc     60

gggaacgcgg cggcagtgag agcgagcggc gccggccctt gcgtccggtg cggcgatgct    120

gaccccggcg ttcgacctca gccaggatcc ggacttcctg actatcgcca tccgcgtgcc    180

ctacgcccgg gtctccgagt tcgacgtcta cttcgagggg tctgacttca agttctacgc    240

caagccatac tttctcagat taacccttcc tggaagaatt gtagaaaatg gaagtgagca    300

agggtcctat gatgcagata aaggaatttt taccattcgc ctgcccaaag aaacccctgg    360

ccagcatttt gaggggctga acatgttaac tgctcttctg gcaccaagaa aatccaggac    420

agcaaaacca cttgtggaag aaataggtgc ttctgagatt cctgaggaag tagttgacga    480

tgaagagttt gattgggaaa ttgagcagac accctgtgaa gaggtatcag aaagtgcttt    540

gaatccgcag tgccactatg gatttggaaa cttacgatca ggagtgttgc aacggttaca    600

ggatgaactg agtgatgtta ttgatattaa ggatccagat ttcacccctg cagctgaacg    660

aagacagaag cgcctggccg ctgagctggc caagtttgat cctgatcatt atctagctga    720

cttttttgaa gatgaggcga ttgaacagat tttgaagtat aatccttggt ggactgacaa    780

atattcaaaa atgatggcct ttttggaaaa gagtcaggaa caagaaaatc atgctacatt    840

agtgtctttt tctgaagaag agaagtatca gctacgaaaa tttgtcaata aatcttatct    900

gctggacaag agagcctgtc gtcaagtgtg ctacagtttg attgatatcc ttctggcata    960

ttgctatgaa acccgtgtca ctgaaggaga gaagaatgtt gaatctgcat ggaatatcag   1020

gaaactgagt ccaacactat gctggtttga gacttggact aacgttcatg atatcatggt   1080

gtcttttgga agaagggtgt tgtgttaccc actctatcgc catttcaagc tggtgatgaa   1140

ggcctacagg gacactataa agatattgca actgggtaaa agtgcagttt taaagtgtct   1200

cctggatatt cacaaaattt ttcaggaaaa tgacccagcg tacatactga atgatctcta   1260

catctcagac tactgtgtgt ggattcagaa agtcaaatcc aaaaagttgg cagctcttgc   1320

agaagcctta aaggaagtct cccttacaaa ggcccagctg gggttagaac tggaagaact   1380

agaagcagca gcactgcttg tccaggagga agaaactgca ttaaaagcag cccattcagt   1440

ttctgggcag cagacacttt gctccagctc tgaggcaagt gattcggagg actcagacag   1500

cagcgtgtca tctggaaacg aagactcagg ctcagattca gaacaagatg aactcaaaga   1560

tagtccatct gagacagtca gttctttgca aggtcccttt cttgaagaaa gcagtgcctt   1620

tcttattgtt gatggtggag tacgcagaaa cacagccatc caggagtctg atgccagtca   1680

gggaaagcca cttgcctctt cctggcctct tggagtgtct gggcctctga tagaggagct   1740

tggggaacaa ctgaagacta cagttcaggt ttctgaaccc aagggcacca ctgctgtaaa   1800

ccgcagcaat attcaggaga gagacggctg tcagacacca aataattgac tcttaggtgg   1860

ttttattcat tgttgagaaa tatggtagat tgggtttcat ttaccgaatg agaattcttc   1920

attttcactt tgtaattttt cttagtatat agtcagccca ctgtatttgt gtgttccaca   1980

tctgtggatt caaccaactg cagatcaaaa atattgaaga aaaaatcgca tctgtaccaa   2040

acatgtacag acttttttct tgttattatt ctctaaataa tacagtatga caactatttc   2100

cacagcattt acattgtatt gggtaatata agtaatctag tgatgattta aactgtgcag   2160

gaggatgtgg gtaggttata tgcaaatact gcaccatttt ttatcagggg cttgagcatc   2220

tgaggatttt agtatcctca ggagtcctgg aaccaacccc ccacagatac ggggacaact   2280

ttatgacatt gtttttcaac caatgaatgt ttataccttt tgttttcctt gccgcgactg   2340

tgaagataaa gttcaaaagt atttttacca aagtgtagct aatatttcaa gctgaaaata   2400

atagttctac tgcccgtgtc tccagaatgt agagcccatc aatattttta ttttaggagg   2460

tgtacttgac acccaataaa ctgcacgtat caaaagtgta caatgtgttg gcgtatgtat   2520

accctgcgta aaactatcac cacaactgaa gtgaggaacg gacccatcat tcccaagtgc   2580

ccttgtgccc tgttattagt ttgcatgtcc tagaattcta tgtaaattga atcatacaat   2640

atgtatccct tttttggtca ggcatatttt actcagtata gttattttga gattcatcca   2700

tgtggtagca tgtgtcacga gtttttgttt ttatgttttt cattgctgag tactgcttca   2760

ttgaatagat ttgttcattg acctatcgat ggacacctgg gttgtttcca gtttggggct   2820

gttataaata aagctgttat gaacatttgt gtacaagtct tca                     2863


<210>  9656
<211>  577
<212>  PRT
<213>  Homosapiens

<400>  9656

Met Leu Thr Pro Ala Phe Asp Leu Ser Gln Asp Pro Asp Phe Leu Thr 
1               5                   10                  15      


Ile Ala Ile Arg Val Pro Tyr Ala Arg Val Ser Glu Phe Asp Val Tyr 
            20                  25                  30          


Phe Glu Gly Ser Asp Phe Lys Phe Tyr Ala Lys Pro Tyr Phe Leu Arg 
        35                  40                  45              


Leu Thr Leu Pro Gly Arg Ile Val Glu Asn Gly Ser Glu Gln Gly Ser 
    50                  55                  60                  


Tyr Asp Ala Asp Lys Gly Ile Phe Thr Ile Arg Leu Pro Lys Glu Thr 
65                  70                  75                  80  


Pro Gly Gln His Phe Glu Gly Leu Asn Met Leu Thr Ala Leu Leu Ala 
                85                  90                  95      


Pro Arg Lys Ser Arg Thr Ala Lys Pro Leu Val Glu Glu Ile Gly Ala 
            100                 105                 110         


Ser Glu Ile Pro Glu Glu Val Val Asp Asp Glu Glu Phe Asp Trp Glu 
        115                 120                 125             


Ile Glu Gln Thr Pro Cys Glu Glu Val Ser Glu Ser Ala Leu Asn Pro 
    130                 135                 140                 


Gln Cys His Tyr Gly Phe Gly Asn Leu Arg Ser Gly Val Leu Gln Arg 
145                 150                 155                 160 


Leu Gln Asp Glu Leu Ser Asp Val Ile Asp Ile Lys Asp Pro Asp Phe 
                165                 170                 175     


Thr Pro Ala Ala Glu Arg Arg Gln Lys Arg Leu Ala Ala Glu Leu Ala 
            180                 185                 190         


Lys Phe Asp Pro Asp His Tyr Leu Ala Asp Phe Phe Glu Asp Glu Ala 
        195                 200                 205             


Ile Glu Gln Ile Leu Lys Tyr Asn Pro Trp Trp Thr Asp Lys Tyr Ser 
    210                 215                 220                 


Lys Met Met Ala Phe Leu Glu Lys Ser Gln Glu Gln Glu Asn His Ala 
225                 230                 235                 240 


Thr Leu Val Ser Phe Ser Glu Glu Glu Lys Tyr Gln Leu Arg Lys Phe 
                245                 250                 255     


Val Asn Lys Ser Tyr Leu Leu Asp Lys Arg Ala Cys Arg Gln Val Cys 
            260                 265                 270         


Tyr Ser Leu Ile Asp Ile Leu Leu Ala Tyr Cys Tyr Glu Thr Arg Val 
        275                 280                 285             


Thr Glu Gly Glu Lys Asn Val Glu Ser Ala Trp Asn Ile Arg Lys Leu 
    290                 295                 300                 


Ser Pro Thr Leu Cys Trp Phe Glu Thr Trp Thr Asn Val His Asp Ile 
305                 310                 315                 320 


Met Val Ser Phe Gly Arg Arg Val Leu Cys Tyr Pro Leu Tyr Arg His 
                325                 330                 335     


Phe Lys Leu Val Met Lys Ala Tyr Arg Asp Thr Ile Lys Ile Leu Gln 
            340                 345                 350         


Leu Gly Lys Ser Ala Val Leu Lys Cys Leu Leu Asp Ile His Lys Ile 
        355                 360                 365             


Phe Gln Glu Asn Asp Pro Ala Tyr Ile Leu Asn Asp Leu Tyr Ile Ser 
    370                 375                 380                 


Asp Tyr Cys Val Trp Ile Gln Lys Val Lys Ser Lys Lys Leu Ala Ala 
385                 390                 395                 400 


Leu Ala Glu Ala Leu Lys Glu Val Ser Leu Thr Lys Ala Gln Leu Gly 
                405                 410                 415     


Leu Glu Leu Glu Glu Leu Glu Ala Ala Ala Leu Leu Val Gln Glu Glu 
            420                 425                 430         


Glu Thr Ala Leu Lys Ala Ala His Ser Val Ser Gly Gln Gln Thr Leu 
        435                 440                 445             


Cys Ser Ser Ser Glu Ala Ser Asp Ser Glu Asp Ser Asp Ser Ser Val 
    450                 455                 460                 


Ser Ser Gly Asn Glu Asp Ser Gly Ser Asp Ser Glu Gln Asp Glu Leu 
465                 470                 475                 480 


Lys Asp Ser Pro Ser Glu Thr Val Ser Ser Leu Gln Gly Pro Phe Leu 
                485                 490                 495     


Glu Glu Ser Ser Ala Phe Leu Ile Val Asp Gly Gly Val Arg Arg Asn 
            500                 505                 510         


Thr Ala Ile Gln Glu Ser Asp Ala Ser Gln Gly Lys Pro Leu Ala Ser 
        515                 520                 525             


Ser Trp Pro Leu Gly Val Ser Gly Pro Leu Ile Glu Glu Leu Gly Glu 
    530                 535                 540                 


Gln Leu Lys Thr Thr Val Gln Val Ser Glu Pro Lys Gly Thr Thr Ala 
545                 550                 555                 560 


Val Asn Arg Ser Asn Ile Gln Glu Arg Asp Gly Cys Gln Thr Pro Asn 
                565                 570                 575     


Asn 
    


<210>  9657
<211>  2499
<212>  DNA
<213>  Homosapiens

<400>  9657
gaagctccgt ccctcacacc gagagttcct gcgcgtgggg agttggagag tttgcgtggc     60

gggaacgcgg cggcagtgag agcgagcggc gccggccctt gcgtccggtg cggcgatgct    120

gaccccggcg ttcgacctca gccaggatcc ggacttcctg actatcgcca tccgcgtgcc    180

ctacgcccgg gtctccgagt tcgacgtcta cttcgagggg tctgacttca agttctacgc    240

caagccatac tttctcagat taacccttcc tggaagaatt gtagaaaatg gaagtgagca    300

agggtcctat gatgcagata aaggaatttt taccattcgc ctgcccaaag aaacccctgg    360

ccagcatttt gaggggctga acatgttaac tgctcttctg gcaccaagaa aatccaggac    420

agcaaaacca cttgtggaag aaataggtgc ttctgagatt cctgaggaag tagttgacga    480

tgaagagttt gattgggaaa ttgagcagac accctgtgaa gaggtatcag aaagtgcttt    540

gaatccgcag tgccactatg gatttggaaa cttacgatca ggagtgttgc aacggttaca    600

ggatgaactg agtgatgtta ttgatattaa ggatccagat ttcacccctg cagctgaacg    660

aagacagaag cgcctggccg ctgagctggc caagtttgat cctgatcatt atctagctga    720

cttttttgaa gatgaggcga ttgaacagat tttgaagtat aatccttggt ggactgacaa    780

atattcaaaa atgatggcct ttttggaaaa gagtcaggaa caagaaaatc atgctacatt    840

agtgtctttt tctgaagaag agaagtatca gctacgaaaa tttgtcaata aatcttatct    900

gctggacaag agagcctgtc gtcaagtgtg ctacagtttg attgatatcc ttctggcata    960

ttgctatgaa acccgtgtca ctgaaggaga gaagaatgtt gaatctgcat ggaatatcag   1020

gaaactgagt ccaacactat gctggtttga gacttggact aacgttcatg atatcatggt   1080

gtcttttgga agaagggtgt tgtgttaccc actctatcgc catttcaagc tggtgatgaa   1140

ggcctacagg gacactataa agatattgca actgggtaaa agtgcagttt taaagtgtct   1200

cctggatatt cacaaaattt ttcaggaaaa tgacccagcg tacatactga atgatctcta   1260

catctcagac tactgtgtgt ggattcagaa agtcaaatcc aaaaagttgg cagctcttgc   1320

agaagcctta aaggaagtct cccttacaaa ggcccagctg gggttagaac tggaagaact   1380

agaagcagca gcactgcttg tccaggagga agaaactgca ttaaaagcag cccattcagt   1440

ttctgggcag cagacacttt gctccagctc tgaggcaagt gattcggagg actcagacag   1500

cagcgtgtca tctggaaacg aagactcagg ctcagattca gaacaagatg aactcaaaga   1560

tagtccatct gagacagtca gttctttgca aggtcccttt cttgaagaaa gcagtgcctt   1620

tcttattgtt gatggtggag tacgcagaaa cacagccatc caggagtctg atgccagtca   1680

gggaaagcca cttgcctctt cctggcctct tggagtgtct gggcctctga tagaggagct   1740

tggggaacaa ctgaagacta cagttcaggt ttctgaaccc aagggcacca ctgctgtaaa   1800

ccgcagcaat attcaggaga gagacggctg tcagacacca aataattgac tcttaggtgg   1860

ttttattcat tgttgagaaa tatggtagat tgggtttcat ttaccgaatg agaattcttc   1920

attttcactt tgtaattttt cttagtatat agtcagccca ctgtatttgt gtgttccaca   1980

tctgtggatt caaccaactg cagatcaaaa atattgaaga aaaaatcgca tctgtaccaa   2040

acatgtacag acttttttct tgttattatt ctctaaataa tacagtatga caactatttc   2100

cacagcattt acattgtatt gggtaatata agtaatctag tgatgattta aactgtgcag   2160

gaggatgtgg gtaggttata tgcaaatact gcaccatttt ttatcagggg cttgagcatc   2220

tgaggatttt agtatcctca ggagtcctgg aaccaacccc ccacagatac ggggacaact   2280

ttatgacatt gtttttcaac caatgaatgt ttataccttt tgttttcctt gccgcgactg   2340

tgaagataaa gttcaaaagt atttttacca aagtgtagct aatatttcaa gctgaaaata   2400

atagttctac tgcccgtgtc tccagaatgt agagcccatc aatattttta ttttaggagg   2460

tgtacttgac acccaataaa ctgcacgtat caaaagtgt                          2499


<210>  9658
<211>  577
<212>  PRT
<213>  Homosapiens

<400>  9658

Met Leu Thr Pro Ala Phe Asp Leu Ser Gln Asp Pro Asp Phe Leu Thr 
1               5                   10                  15      


Ile Ala Ile Arg Val Pro Tyr Ala Arg Val Ser Glu Phe Asp Val Tyr 
            20                  25                  30          


Phe Glu Gly Ser Asp Phe Lys Phe Tyr Ala Lys Pro Tyr Phe Leu Arg 
        35                  40                  45              


Leu Thr Leu Pro Gly Arg Ile Val Glu Asn Gly Ser Glu Gln Gly Ser 
    50                  55                  60                  


Tyr Asp Ala Asp Lys Gly Ile Phe Thr Ile Arg Leu Pro Lys Glu Thr 
65                  70                  75                  80  


Pro Gly Gln His Phe Glu Gly Leu Asn Met Leu Thr Ala Leu Leu Ala 
                85                  90                  95      


Pro Arg Lys Ser Arg Thr Ala Lys Pro Leu Val Glu Glu Ile Gly Ala 
            100                 105                 110         


Ser Glu Ile Pro Glu Glu Val Val Asp Asp Glu Glu Phe Asp Trp Glu 
        115                 120                 125             


Ile Glu Gln Thr Pro Cys Glu Glu Val Ser Glu Ser Ala Leu Asn Pro 
    130                 135                 140                 


Gln Cys His Tyr Gly Phe Gly Asn Leu Arg Ser Gly Val Leu Gln Arg 
145                 150                 155                 160 


Leu Gln Asp Glu Leu Ser Asp Val Ile Asp Ile Lys Asp Pro Asp Phe 
                165                 170                 175     


Thr Pro Ala Ala Glu Arg Arg Gln Lys Arg Leu Ala Ala Glu Leu Ala 
            180                 185                 190         


Lys Phe Asp Pro Asp His Tyr Leu Ala Asp Phe Phe Glu Asp Glu Ala 
        195                 200                 205             


Ile Glu Gln Ile Leu Lys Tyr Asn Pro Trp Trp Thr Asp Lys Tyr Ser 
    210                 215                 220                 


Lys Met Met Ala Phe Leu Glu Lys Ser Gln Glu Gln Glu Asn His Ala 
225                 230                 235                 240 


Thr Leu Val Ser Phe Ser Glu Glu Glu Lys Tyr Gln Leu Arg Lys Phe 
                245                 250                 255     


Val Asn Lys Ser Tyr Leu Leu Asp Lys Arg Ala Cys Arg Gln Val Cys 
            260                 265                 270         


Tyr Ser Leu Ile Asp Ile Leu Leu Ala Tyr Cys Tyr Glu Thr Arg Val 
        275                 280                 285             


Thr Glu Gly Glu Lys Asn Val Glu Ser Ala Trp Asn Ile Arg Lys Leu 
    290                 295                 300                 


Ser Pro Thr Leu Cys Trp Phe Glu Thr Trp Thr Asn Val His Asp Ile 
305                 310                 315                 320 


Met Val Ser Phe Gly Arg Arg Val Leu Cys Tyr Pro Leu Tyr Arg His 
                325                 330                 335     


Phe Lys Leu Val Met Lys Ala Tyr Arg Asp Thr Ile Lys Ile Leu Gln 
            340                 345                 350         


Leu Gly Lys Ser Ala Val Leu Lys Cys Leu Leu Asp Ile His Lys Ile 
        355                 360                 365             


Phe Gln Glu Asn Asp Pro Ala Tyr Ile Leu Asn Asp Leu Tyr Ile Ser 
    370                 375                 380                 


Asp Tyr Cys Val Trp Ile Gln Lys Val Lys Ser Lys Lys Leu Ala Ala 
385                 390                 395                 400 


Leu Ala Glu Ala Leu Lys Glu Val Ser Leu Thr Lys Ala Gln Leu Gly 
                405                 410                 415     


Leu Glu Leu Glu Glu Leu Glu Ala Ala Ala Leu Leu Val Gln Glu Glu 
            420                 425                 430         


Glu Thr Ala Leu Lys Ala Ala His Ser Val Ser Gly Gln Gln Thr Leu 
        435                 440                 445             


Cys Ser Ser Ser Glu Ala Ser Asp Ser Glu Asp Ser Asp Ser Ser Val 
    450                 455                 460                 


Ser Ser Gly Asn Glu Asp Ser Gly Ser Asp Ser Glu Gln Asp Glu Leu 
465                 470                 475                 480 


Lys Asp Ser Pro Ser Glu Thr Val Ser Ser Leu Gln Gly Pro Phe Leu 
                485                 490                 495     


Glu Glu Ser Ser Ala Phe Leu Ile Val Asp Gly Gly Val Arg Arg Asn 
            500                 505                 510         


Thr Ala Ile Gln Glu Ser Asp Ala Ser Gln Gly Lys Pro Leu Ala Ser 
        515                 520                 525             


Ser Trp Pro Leu Gly Val Ser Gly Pro Leu Ile Glu Glu Leu Gly Glu 
    530                 535                 540                 


Gln Leu Lys Thr Thr Val Gln Val Ser Glu Pro Lys Gly Thr Thr Ala 
545                 550                 555                 560 


Val Asn Arg Ser Asn Ile Gln Glu Arg Asp Gly Cys Gln Thr Pro Asn 
                565                 570                 575     


Asn 
    


<210>  9659
<211>  1240
<212>  DNA
<213>  Homosapiens

<400>  9659
gtctcacgcc cataatccca gcactttggg agaccaagat ccaaaaagtt ggcagctctt     60

gcagaagcct taaaggaagt ctcccttaca aaggcccagc tggggttaga actggaagaa    120

ctagaagcag cagcactgct tgtccaggag gaagaaactg cattaaaagc agcccattca    180

gtttctgggc agcagacact ttgctccagc tctgaggcaa gtgattcgga ggactcagac    240

agcagcgtgt catctggaaa cgaagactca ggctcagatt cagaacaaga tgaactcaaa    300

gatagtccat ctgagacagt cagttctttg caaggtccct ttcttgaaga aagcagtgcc    360

tttcttattg ttgatggtgg agtacgcaga aacacagcca tccaggagtc tgatgccagt    420

cagggaaagc cacttgcctc ttcctggcct cttggagtgt ctgggcctct gatagaggag    480

cttggggaac aactgaagac tacagttcag gtttctgaac ccaagggcac cactgctgta    540

aaccgcagca atattcagga gagagacggc tgtcagacac caaataattg actcttaggt    600

ggttttattc attgttgaga aatatggtag attgggtttc atttaccgaa tgagaattct    660

tcattttcac tttgtaattt ttcttagtat atagtcagcc cactgtattt gtgtgttcca    720

catctgtgga ttcaaccaac tgcagatcaa aaatattgaa gaaaaaatcg catctgtacc    780

aaacatgtac agactttttt cttgttatta ttctctaaat aatacagtat gacaactatt    840

tccacagcat ttacattgta ttgggtaata taagtaatct agtgatgatt taaactgtgc    900

aggaggatgt gggtaggtta tatgcaaata ctgcaccatt ttttatcagg ggcttgagca    960

tctgaggatt ttagtatcct caggagtcct ggaaccaacc ccccacagat acggggacaa   1020

ctttatgaca ttgtttttca accaatgaat gtttatacct tttgttttcc ttgccgcgac   1080

tgtgaagata aagttcaaaa gtatttttac caaagtgtag ctaatatttc aagctgaaaa   1140

taatagttct actgcccgtg tctccagaat gtagagccca tcaatatttt tattttagga   1200

ggtgtacttg acacccaata aactgcacgt atcaaaagtg                         1240


<210>  9660
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  9660

Met Asn Ser Lys Ile Val His Leu Arg Gln Ser Val Leu Cys Lys Val 
1               5                   10                  15      


Pro Phe Leu Lys Lys Ala Val Pro Phe Leu Leu Leu Met Val Glu Tyr 
            20                  25                  30          


Ala Glu Thr Gln Pro Ser Arg Ser Leu Met Pro Val Arg Glu Ser His 
        35                  40                  45              


Leu Pro Leu Pro Gly Leu Leu Glu Cys Leu Gly Leu 
    50                  55                  60  


<210>  9661
<211>  585
<212>  DNA
<213>  Homosapiens

<400>  9661
caattgaaga agaaaactct acaataatag tgaaattagt ggaaagtcct tattttgaat     60

attaaaggat tgattaaaag attgatttga gcatcacatg attgagaggc ccttgaggaa    120

actgatgata cccttgattt ttttctgtaa gaattacctt ctctgattct gctacaaaaa    180

gaccaacatg aagtgatgaa tgttagatgg tgctgtaata taattttgtt agaacaatta    240

caaatacaat taatatttgg ttcattcttt gctgtttttg agaattagta catggttgca    300

gttttaacct acatattgtt aacattgtta aatatttcat caatttattt ttgtagtttg    360

tagttttgtt tcaaggtgaa gtatttggtt tttgttgttg tttttttgac acaagagtct    420

ccctctgttg ctgaggctgg agtgtagtgc tgcagtctct gctcactaca acctccgcct    480

cccaggtaca agagaactgc ttgaacccag gaggtggagg ttgcagtgag ccgagatcgt    540

gccattgcat tccagcttgg gcaatagaat gagactccat ctcgg                    585


<210>  9662
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  9662

Met Asn Val Arg Trp Cys Cys Asn Ile Ile Leu Leu Glu Gln Leu Gln 
1               5                   10                  15      


Ile Gln Leu Ile Phe Gly Ser Phe Phe Ala Val Phe Glu Asn 
            20                  25                  30  


<210>  9663
<211>  371
<212>  DNA
<213>  Homosapiens

<400>  9663
tggtgcctgg gagccggcgt tgaaccggcg ggatgactag caaccgagcc tttttcgagg     60

ttcttagaga tgattttaac agcactggct tgacagtgtc tttgcctcag agattttctt    120

cattttccca ccagctcagt catgcatatc aaaagaagtt tatgcacaat tgaaggacac    180

caactaaaat ttgaacaaat aagagatttg taactgggga tcccctggaa gaatcgtctg    240

gaaattacga ccttcatctg gcgattgcag ctgttaaagt ctccaaagaa gccattctta    300

cattgtgttg tgaaattatt actctatctc aaatctgtgc cagaaagaaa ataaaatgtg    360

tgtttatgtg t                                                         371


<210>  9664
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  9664

Met Thr Ser Asn Arg Ala Phe Phe Glu Val Leu Arg Asp Asp Phe Asn 
1               5                   10                  15      


Ser Thr Gly Leu Thr Val Ser Leu Pro Gln Arg Phe Ser Ser Phe Ser 
            20                  25                  30          


His Gln Leu Ser His Ala Tyr Gln Lys Lys Phe Met His Asn 
        35                  40                  45      


<210>  9665
<211>  1806
<212>  DNA
<213>  Homosapiens

<400>  9665
gtcgccgccg ccgccggccg cccgccggcc gccacgaccc cagtccccgg cgggcgggcg     60

gaggaggcga ccgccgcgcg ctgctgcact catcctgccg ccgccgcgat gcgcagaggg    120

gccgagccgc ctgggggccg ccgccgccgc cgcgccgcac catgaagctc cgcagcaagg    180

cggcggcgct gctcttgctc gcgctggccg cgctgctgct ggcgctgctg tccctgcgcg    240

ctggccgcgc tgagccccca gcgctgcccg cgcgccccgc gtccgccccg cagcgccacc    300

ccgcgcctgt ccccgcgcgc tggccggggc cgggcgccct ccccggggcc agcccgggag    360

ttcggaggcg ccggcccccg cgtccgcgcc cccgagcggg ccgccggggc gctgcgagac    420

tggagaagtt ggcgaggagg cctggagaac ccaggagttt ccaagctgtg ctgccacccg    480

agctctggat ccacctggct gtggtggcct gtggcaatcg gctggaggag acgctggtca    540

tgctcaaatc agctgtgctt tttagccaca ggaagatcca attccacatc ttcactgaag    600

actctctgaa gcccgagttt gataagcagt tacgccagtg gcctgactca tatacaaaga    660

agtttgagca cagaatctac cccatcacat tttctgttgg aaaccctcag gagtggaaga    720

aattgttcaa accctgtgct gcccagagac tctttcttcc ggtgatttta aaggatgtgg    780

actcacttct ctacgtggac accgatgtcc tctttctgag acctgttgat gacatctgga    840

agcttctgag gctgtttaat tccacccagc ttgcagccat ggcccctgag cacgaaatcc    900

ccaagattgg ctggtacagc cgctttgcta ggcatccttt ctatggctct gcaggagtta    960

attcaggagt catgttaatg aatttaactc ggataagaag tacccagttc aagaacagca   1020

tgattccaac aggcctggct tgggaggaca tgttgtaccc tctgtaccag aagtacaaga   1080

atgccatcac gtggggagac caggatttat taaatattat tttttatttc aacccagagt   1140

gtctctatgt attcccctgc cagtggaact accgtcccga tcactgcatg tacggaagca   1200

actgcagaga ggctgagcat gaaggtgtgt ctgttctgca tggaaaccga ggcgtctacc   1260

atgacgataa gcaaccaacg ttcagagcac tctatgaagc aatacgggat tttccctttc   1320

aagacaatct ctttcaatcc atgtattacc cccttcagct gaagtttttg gagactgtgc   1380

acactttatg tggacgaatc ccgcaagttt ttctgaagca aattgagaaa acaatgaaaa   1440

gggcttatga gaaacacgtc atcatccatg ttggccccaa ccagatgcac tgaatatttt   1500

gtcttgttgc aagtcaatta ggtgtcttgt gaccaaggaa atactaatct ctaagctgcc   1560

tgggtctttt tgtgtgaata tttaatggtg ctccatgact gttgagtttt aaaaacctcg   1620

ttaaattttg ccaaatcagt tgcccccaaa agggaatatg cttttcctta tttttttttc   1680

taaaatgcta tttatctcta aggaaaaaaa aaaaagacta ttactcattt aacattgttt   1740

aagcaggttg agctagctgt gaaaatagct tttgtgagcc ttctaattcc taaacgtctg   1800

agacca                                                              1806


<210>  9666
<211>  443
<212>  PRT
<213>  Homosapiens

<400>  9666

Met Lys Leu Arg Ser Lys Ala Ala Ala Leu Leu Leu Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Ala Gly Arg Ala Glu Pro 
            20                  25                  30          


Pro Ala Leu Pro Ala Arg Pro Ala Ser Ala Pro Gln Arg His Pro Ala 
        35                  40                  45              


Pro Val Pro Ala Arg Trp Pro Gly Pro Gly Ala Leu Pro Gly Ala Ser 
    50                  55                  60                  


Pro Gly Val Arg Arg Arg Arg Pro Pro Arg Pro Arg Pro Arg Ala Gly 
65                  70                  75                  80  


Arg Arg Gly Ala Ala Arg Leu Glu Lys Leu Ala Arg Arg Pro Gly Glu 
                85                  90                  95      


Pro Arg Ser Phe Gln Ala Val Leu Pro Pro Glu Leu Trp Ile His Leu 
            100                 105                 110         


Ala Val Val Ala Cys Gly Asn Arg Leu Glu Glu Thr Leu Val Met Leu 
        115                 120                 125             


Lys Ser Ala Val Leu Phe Ser His Arg Lys Ile Gln Phe His Ile Phe 
    130                 135                 140                 


Thr Glu Asp Ser Leu Lys Pro Glu Phe Asp Lys Gln Leu Arg Gln Trp 
145                 150                 155                 160 


Pro Asp Ser Tyr Thr Lys Lys Phe Glu His Arg Ile Tyr Pro Ile Thr 
                165                 170                 175     


Phe Ser Val Gly Asn Pro Gln Glu Trp Lys Lys Leu Phe Lys Pro Cys 
            180                 185                 190         


Ala Ala Gln Arg Leu Phe Leu Pro Val Ile Leu Lys Asp Val Asp Ser 
        195                 200                 205             


Leu Leu Tyr Val Asp Thr Asp Val Leu Phe Leu Arg Pro Val Asp Asp 
    210                 215                 220                 


Ile Trp Lys Leu Leu Arg Leu Phe Asn Ser Thr Gln Leu Ala Ala Met 
225                 230                 235                 240 


Ala Pro Glu His Glu Ile Pro Lys Ile Gly Trp Tyr Ser Arg Phe Ala 
                245                 250                 255     


Arg His Pro Phe Tyr Gly Ser Ala Gly Val Asn Ser Gly Val Met Leu 
            260                 265                 270         


Met Asn Leu Thr Arg Ile Arg Ser Thr Gln Phe Lys Asn Ser Met Ile 
        275                 280                 285             


Pro Thr Gly Leu Ala Trp Glu Asp Met Leu Tyr Pro Leu Tyr Gln Lys 
    290                 295                 300                 


Tyr Lys Asn Ala Ile Thr Trp Gly Asp Gln Asp Leu Leu Asn Ile Ile 
305                 310                 315                 320 


Phe Tyr Phe Asn Pro Glu Cys Leu Tyr Val Phe Pro Cys Gln Trp Asn 
                325                 330                 335     


Tyr Arg Pro Asp His Cys Met Tyr Gly Ser Asn Cys Arg Glu Ala Glu 
            340                 345                 350         


His Glu Gly Val Ser Val Leu His Gly Asn Arg Gly Val Tyr His Asp 
        355                 360                 365             


Asp Lys Gln Pro Thr Phe Arg Ala Leu Tyr Glu Ala Ile Arg Asp Phe 
    370                 375                 380                 


Pro Phe Gln Asp Asn Leu Phe Gln Ser Met Tyr Tyr Pro Leu Gln Leu 
385                 390                 395                 400 


Lys Phe Leu Glu Thr Val His Thr Leu Cys Gly Arg Ile Pro Gln Val 
                405                 410                 415     


Phe Leu Lys Gln Ile Glu Lys Thr Met Lys Arg Ala Tyr Glu Lys His 
            420                 425                 430         


Val Ile Ile His Val Gly Pro Asn Gln Met His 
        435                 440             


<210>  9667
<211>  1650
<212>  DNA
<213>  Homosapiens

<400>  9667
caaatcccaa ttttgccgct ttctggtgat ttgccattaa ctgtgccctt accttgctgg     60

gcctcagttt tttcatcagt caagtgtaga taataagatt atctacctca aacaagtgtt    120

atgaaaattc aacaaaatga tagtctttat gcttttagta cagagcctga catacagttt    180

gtgcaataat tagaagttgt tttggccagg tgcggtggct cacacctgtg gtcccagcta    240

tgggactaca ggcatgagcc actgtgccca gctgacatat tctcacttaa tagaattata    300

gagaaatttt tcatgttttt ctttttctct cccacttttt catattcctc tttttcattt    360

ttgcctttcc gtttctgtct atgatgtagg cttctgagga gaaccaagaa gcttggcttt    420

agtggtagaa tgacagaact tagggatccc ttgcaggcta gaacaaagtt ctgaccctta    480

gaccaaatct ttatgttaag agttttccag aattcaaaaa aaaaaaaaaa atcaatcaac    540

acaacacaca cacacataca tacacacaca ctgcctttaa aaggaggagc caatatttgt    600

tgtacctgtg aactgaggaa ttatagataa accttaggtc aaatcatttc acaattgcat    660

tggtggtatt gaaaaatgat gagatttctc tgacagagag ctttgtccta gtttttgttc    720

ttcataggtc aaaactggca atattctctt gtctgcaaga taaagtgttt gtgcttctat    780

caccatatgc atgaacatgt aagaatcaga tacaatttct gcttcatcag tttcacatgt    840

tcatgttgtc actgaaaaaa tgcatctact gtttatagct cccaaggaga ccccaaatcc    900

tttttttttc ttttgagatg gagtcttgct cttgttgccc aggctggaga gcagtagcgc    960

gatctcagct cactgcaacc cccacctcct gggttcaagt gattctcctg cctcagcctc   1020

cccagtagct gggatttaca ggtgcccgct accatgcctg gctaattttt gtatttttag   1080

tagagacagg ctttcaccat gttggccagg ctgatctcaa actcctgacc tcaggtgatc   1140

cacccacctc ggcctccgaa agtgctggga ttacaggagt gagccaccgc gcctggcccc   1200

gtattcattt tttatactgg aaaacatttt ttttgtaatt tttctttgca aagaaatgag   1260

cataaaaatg aatactccaa agaaaaggaa ttattatggc aaattaaaag ggacacggta   1320

ctatgattta attactgtct tgtcttttta aaatgtcatc tcttgtttta cccttttttt   1380

aaataaaagc tttaaaaaca tgtctttggg tattattctg gaggtatgtt tcttttatat   1440

aagatttcaa gtttaaacat ttacaataag taataatatt taaattctta taacaagtaa   1500

tgaaatattt ggtttagtaa ttagcttagt ctattttaaa aaatcattaa aatttgcttt   1560

gtttttaaga atgccatact acaaatgatg ttatttggtt ttaatggtgt tttgtgttta   1620

agatagaata aatagagttt gaagaatgtg                                    1650


<210>  9668
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  9668

Met Leu Arg Val Phe Gln Asn Ser Lys Lys Lys Lys Lys Ser Ile Asn 
1               5                   10                  15      


Thr Thr His Thr His Ile His Thr His Thr Leu Pro Leu Lys Gly Gly 
            20                  25                  30          


Ala Asn Ile Cys Cys Thr Cys Glu Leu Arg Asn Tyr Arg 
        35                  40                  45  


<210>  9669
<211>  1364
<212>  DNA
<213>  Homosapiens

<400>  9669
ttaacataaa gatttggtct aagggtcaga actttgttct agcctgcaag ggatccctaa     60

gttctgtcat tctaccacta aagccaagct tcttggttct cctcagaagc ctacatcata    120

gacagaaacg gaaaggcaaa aatgaaaaag aggaatatga aaaagtggga gagaaaaaga    180

aaaacatgaa aaatttctct ataattctat taagtgagaa tatgtcagct gggcacagtg    240

gctcatgcct gtagtcccag tactttggga ggccaaggca ggtggatcac ttgagctcag    300

gagtttgaga ccagcctggc caacatggtg aaatcccatc tctactaaac attcaaaaat    360

tagctgggca tggtggtgca cacctgtagt cccagctact cggaagcctg aggcatgaga    420

atcgtttgaa cctgggaggc ggaggctgca gtgagctgag attgtgccac tgcactccag    480

cctaggtgac agacggagac tccatctcaa aaaaaaaaaa aaaagagaga atatgtcctg    540

tgttagcttg cttaggaaat aaagagagag agagagaggg agggagggaa agagagaaag    600

agagagagag aaagagagtg agagaaagag agagcaagag agcaagagta agaaagaaag    660

aaaaagaaag aaagaaaaga ggccgggcgc atattcaatg tggcatatgg ggcagcacca    720

cctctggcaa actttaaacc agagagtgca tgttttagca ggccactgaa ttaaaatttg    780

tggctcctgg atttcaaagg cggttaatgt agtaatttgc tgggagttat caaaggcaga    840

gaaaatattg ctccatggta atatcctagc tatggaaaat aattagcact ttcaggcagc    900

aaggattaga aaagcaaatt ttctctgaat tctctgccaa attcagctaa aatttcagga    960

tacagcacag gaattccaag gcagacaacc gcacgaggtt ctaaggtttc acattctcaa   1020

aattcatcat tctagaatgt tctagggtga tatcattgac ctttgcgggc aacccttttc   1080

tgcacagtca gaccagtact ggtagttgag agttgtgggt aaacttggct ctcataaaaa   1140

agaaaggcat tgtatttcaa gtctttacag tagatgtttt tgtgggactt atcaaaggag   1200

agaaggaacc tctttgagtt ggtgagccat caacaaatct gagtgccatt tgtgtgtttc   1260

actggccatt ctgaacaagt agaaaggaaa ctaggatgga agttaggaaa ttatgttcca   1320

tcctggctct ttcactaaaa cccaatttat gggtatataa gatg                    1364


<210>  9670
<211>  83
<212>  PRT
<213>  Homosapiens

<400>  9670

Val Thr Asp Gly Asp Ser Ile Ser Lys Lys Lys Lys Lys Glu Arg Ile 
1               5                   10                  15      


Cys Pro Val Leu Ala Cys Leu Gly Asn Lys Glu Arg Glu Arg Glu Gly 
            20                  25                  30          


Gly Arg Glu Arg Glu Lys Glu Arg Glu Arg Lys Arg Val Arg Glu Arg 
        35                  40                  45              


Glu Ser Lys Arg Ala Arg Val Arg Lys Lys Glu Lys Glu Arg Lys Lys 
    50                  55                  60                  


Arg Gly Arg Ala His Ile Gln Cys Gly Ile Trp Gly Ser Thr Thr Ser 
65                  70                  75                  80  


Gly Lys Leu 
            


<210>  9671
<211>  1045
<212>  DNA
<213>  Homosapiens

<400>  9671
ctacttgttc agaatggcca gtgaaacaca caaatggcac tcagatttgt tgatggctca     60

ccaactcaaa gaggttcctt ctctcctttg ataagtccca caaaaacatc tactgtaaag    120

acttgaaata caatgccttt cttttttatg agagccaagt ttacccacaa ctctcaacta    180

ccagtactgg tctgactgtg cagaaaaggg ttgcccgcaa aggtcaatga tatcacccta    240

gaacattcta gaatgatgaa ttttgagaat gtgaaacctt agaacctcgt gcggttgtct    300

gccttggaat tcctgtgctg tatcctgaaa ttttagctga atttggcaga gaattcagag    360

aaaatttgct tttctaatcc ttgctgcctg aaagtgctaa ttattttcca tagctaggat    420

attaccatgg agcaatattt tctctgcctt tgataactcc cagcaaatta ctacattaac    480

cgcctttgaa atccaggagc cacaaatttt aattcagtgg cctgctaaaa catgcactct    540

ctggtttaaa gtttgccaga ggtggtgctg ccccatatcc accgcgcctg gccccgtatt    600

cattttttat actggaaaac attttttttg taatttttct ttgcaaagaa atgagcataa    660

aaatgaatac tccaaagaaa aggaattatt atggcaaatt aaaagggaca cggtactatg    720

atttaattac tgtcttgtct ttttaaaatg tcatctcttg ttttaccctt tttttaaata    780

aaagctttaa aaacatgtct ttgggtatta ttctggaggt atgtttcttt tatataagat    840

ttcaagttta aacatttaca ataagtaata atatttaaat tcttataaca agtaatgaaa    900

tatttggttt agtaattagc ttagtctatt ttaaaaaatc attaaaattt gctttgtttt    960

taagaatgcc atactacaaa tgatgttatt tggttttaat ggtgttttgt gtttaagata   1020

gaataaatag agtttgaaga atgtg                                         1045


<210>  9672
<211>  31
<212>  PRT
<213>  Homosapiens

<400>  9672

Met Ser Ile Lys Met Asn Thr Pro Lys Lys Arg Asn Tyr Tyr Gly Lys 
1               5                   10                  15      


Leu Lys Gly Thr Arg Tyr Tyr Asp Leu Ile Thr Val Leu Ser Phe 
            20                  25                  30      


<210>  9673
<211>  1794
<212>  DNA
<213>  Homosapiens

<400>  9673
actaccagta ctggtctgac tgtgcagaaa agggttgccc gcaaaggtca atgatatcac     60

cctagaacat tctagaatga tgaattttga gaatgtgaaa ccttagaacc tcgtgcggtt    120

gtctgccttg gaattcctgt gctgtatcct gaaattttag ctgaatttgg cagagaattc    180

agagaaaatt tgcttttcta atccttgctg cctgaaagtg ctaattattt tccatagcta    240

ggatattacc atggagcaat attttctctg cctttgataa ctcccagcaa attactacat    300

taaccgcctt tgaaatccag gagccacaaa ttttaattca gtggcctgct aaaacatgca    360

ctctctggtt taaagtttgc cagaggtggt gctgccccat atccactgtg cccagctgac    420

atattctcac ttaatagaat tatagagaaa tttttcatgt ttttcttttt ctctcccact    480

ttttcatatt cctctttttc atttttgcct ttccgtttct gtctatgatg taggcttctg    540

aggagaacca agaagcttgg ctttagtggt agaatgacag aacttaggga tcccttgcag    600

gctagaacaa agttctgacc cttagaccaa atctttatgt taagagtttt ccagaattca    660

aaaaaaaaaa aaaaatcaat caacacaaca cacacacaca tacatacaca cacactgcct    720

ttaaaaggag gagccaatat ttgttgtacc tgtgaactga ggaattatag ataaacctta    780

ggtcaaatca tttcacaatt gcattggtgg tattgaaaaa tgatgagatt tctctgacag    840

agagctttgt cctagttttt gttcttcata ggtcaaaact ggcaatattc tcttgtctgc    900

aagataaagt gtttgtgctt ctatcaccat atgcatgaac atgtaagaat cagatacaat    960

ttctgcttca tcagtttcac atgttcatgt tgtcactgaa aaaatgcatc tactgtttat   1020

agctcccaag gagaccccaa atcctttttt tttcttttga gatggagtct tgctcttgtt   1080

gcccaggctg gagagcagta gcgcgatctc agctcactgc aacccccacc tcctgggttc   1140

aagtgattct cctgcctcag cctccccagt agctgggatt tacaggtgcc cgctaccatg   1200

cctggctaat ttttgtattt ttagtagaga caggctttca ccatgttggc caggctgatc   1260

tcaaactcct gacctcaggt gatccaccca cctcggcctc cgaaagtgct gggattacag   1320

gagtgagcca ccgcgcctgg ccccgtattc attttttata ctggaaaaca ttttttttgt   1380

aatttttctt tgcaaagaaa tgagcataaa aatgaatact ccaaagaaaa ggaattatta   1440

tggcaaatta aaagggacac ggtactatga tttaattact gtcttgtctt tttaaaatgt   1500

catctcttgt tttacccttt ttttaaataa aagctttaaa aacatgtctt tgggtattat   1560

tctggaggta tgtttctttt atataagatt tcaagtttaa acatttacaa taagtaataa   1620

tatttaaatt cttataacaa gtaatgaaat atttggttta gtaattagct tagtctattt   1680

taaaaaatca ttaaaatttg ctttgttttt aagaatgcca tactacaaat gatgttattt   1740

ggttttaatg gtgttttgtg tttaagatag aataaataga gtttgaagaa tgtg         1794


<210>  9674
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  9674

Met Leu Arg Val Phe Gln Asn Ser Lys Lys Lys Lys Lys Ser Ile Asn 
1               5                   10                  15      


Thr Thr His Thr His Ile His Thr His Thr Leu Pro Leu Lys Gly Gly 
            20                  25                  30          


Ala Asn Ile Cys Cys Thr Cys Glu Leu Arg Asn Tyr Arg 
        35                  40                  45  


<210>  9675
<211>  416
<212>  DNA
<213>  Homosapiens

<400>  9675
gataacacat tgtctgtcac tggctggttg taatgcaagg aagggacaaa gatgaaatgg     60

aaacatgttc cttttttggt catgatatca ctcctcagct tatccccaaa tcacctgttt    120

ctggcccagc ttattccaga ccctgaagat gtagagaggg ggaacgacca cgggacgcca    180

atccccacct ctgataacga tgacaattcg ctgggctata caggtagagt gtctctttcc    240

caaatactaa cttcctcctg aaatgcctcc acctccatca accatcaacc acctgtataa    300

aattaatcga atcatccctg cttccagcta acaaccacaa tttctcattt ttcaaacttc    360

attctgttca tatcagatca tattgctaaa gtaaacactt ttaagaacag aaatgt        416


<210>  9676
<211>  69
<212>  PRT
<213>  Homosapiens

<400>  9676

Met Lys Trp Lys His Val Pro Phe Leu Val Met Ile Ser Leu Leu Ser 
1               5                   10                  15      


Leu Ser Pro Asn His Leu Phe Leu Ala Gln Leu Ile Pro Asp Pro Glu 
            20                  25                  30          


Asp Val Glu Arg Gly Asn Asp His Gly Thr Pro Ile Pro Thr Ser Asp 
        35                  40                  45              


Asn Asp Asp Asn Ser Leu Gly Tyr Thr Gly Arg Val Ser Leu Ser Gln 
    50                  55                  60                  


Ile Leu Thr Ser Ser 
65                  


<210>  9677
<211>  308
<212>  DNA
<213>  Homosapiens

<400>  9677
gctgccttga aaatctgaac tccttaatgc catttccttc agcaaaacag gcatctctta     60

gagtgtcaag acaagaccca gagtcttggt tcctgtgttt gctccctgag tgaaaaatca    120

tgcttcaaat tgattcatag atctggcaaa taccactgat actagcagct gtttgctaat    180

attctgaata gagcttgcca cagagagttc acggatttaa gacatacttg aaaaaaattt    240

gaaatgattt cattacatga agaaaaaaat aggtattgca gcatcctgtt accaagaaat    300

aaagatag                                                             308


<210>  9678
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  9678

Cys His Phe Leu Gln Gln Asn Arg His Leu Leu Glu Cys Gln Asp Lys 
1               5                   10                  15      


Thr Gln Ser Leu Gly Ser Cys Val Cys Ser Leu Ser Glu Lys Ser Cys 
            20                  25                  30          


Phe Lys Leu Ile His Arg Ser Gly Lys Tyr His 
        35                  40              


<210>  9679
<211>  444
<212>  DNA
<213>  Homosapiens

<400>  9679
tggctggttg taatgcaagg aagggacaaa gatgaaatgg aaacatgttc cttttttggt     60

catgatatca ctcctcagct tatccccaaa tcacctgttt ctggcccagc ttattccagg    120

gctcaagcct actaaagaac caagaaaaat tctgtaatac aataaaattc gtctccaccc    180

tttttaatgg tttaaaggat caattcttct ccaagcccat cactgacctt cctgctgaac    240

ttcaactgga tgcaaaacaa acccacaaat tctattttag agaattatgg aagtcaaatg    300

acgtatgtat tcaggtcaca gaaaatgtat gatgcatggt gccatttaaa aaaatatttg    360

ctctgtgaag atctgctttc tgcattatgg aagaaaagca attcatattt ttcaacggct    420

tgcattaaaa tcctacactg tgta                                           444


<210>  9680
<211>  64
<212>  PRT
<213>  Homosapiens

<400>  9680

Met Gln Asn Lys Pro Thr Asn Ser Ile Leu Glu Asn Tyr Gly Ser Gln 
1               5                   10                  15      


Met Thr Tyr Val Phe Arg Ser Gln Lys Met Tyr Asp Ala Trp Cys His 
            20                  25                  30          


Leu Lys Lys Tyr Leu Leu Cys Glu Asp Leu Leu Ser Ala Leu Trp Lys 
        35                  40                  45              


Lys Ser Asn Ser Tyr Phe Ser Thr Ala Cys Ile Lys Ile Leu His Cys 
    50                  55                  60                  


<210>  9681
<211>  7312
<212>  DNA
<213>  Homosapiens

<400>  9681
gaggtcagga gattgagacc atcctggcta acacggtgaa accccgtctc tactaaaaat     60

acaaaaaaat tagccgggcg tggcggcggg cgcctgtagt cccagctact tgggaggctg    120

aggcaggaga atggtgcgaa cccgggaggc agattttgca gagagccgag atcgtgccac    180

tgcactccag cctgggcgac agagcaagac tccgtctcaa aacaaaaaac aaacaaacaa    240

atatggagca ttctgatatg aataagacac ttgctcactt ctcaattcct tggtgtccag    300

ctctacaagt gtatatagac ttccaaagaa tatttaaatc ctttaacaaa aatgccacct    360

aagaaaatat gaaatacttc agtctgtctg tcagtgctca cttcctgtct agaaactttc    420

aggctccggc acaaatgaac catgttcttc gcctaagtca tttatggaac atctgctttc    480

ggtttagcat cagtgtgcta ttaatccagg tcttccaaga aacaaatgcc aagatggtat    540

taaacatgaa atgattttaa ttgtttacat gcctgaaagt aaataaagag ggtgccagct    600

aaggctgaaa aagtcttcag tgatataaat tttaccacac ttaaagagag agaggaaaag    660

tttaagtgga agctcctact cagccatgct gtctaaggaa gatttggcaa aaccttgagc    720

taaagtcagc caacggaaat cccacctttc tccaaagaat ggatctgctt tactatcttg    780

cttggtctta ttgctttgtg acctagtaat atctttctcg agtgcatgaa acatctcaga    840

aatgcaaaca tcaaggaaga tactaatcct ttcttccagt ttctgtgtga gggttggagg    900

ctgactttgg tggtgatctt gctccaaatt atagaactac atcctgtcat gaagagaagt    960

ttgtcttctc gataaagcca agtagctaac agagatggtc accccaatta ccagatggac   1020

ataattatac ttgaatgctg acctacaaca ttttgtgctg tgcagaggct ttgaaaatca   1080

aacaactttg aaaatacaaa gcaccgcgtg gatggcctca ctctgtcgct caggctggag   1140

tggcacgatc ttggctcact gcagtctctg cctcctcctc ttggatgcaa gcaattcggc   1200

ctccaagtag ctgagattac agagaggctg aaaactcaag aaatgtggac taagtgtgtg   1260

ggcaagtgtg tcactgctga ctaaaactat gaacagacag agtctcactc tgtcatccag   1320

gctggagtcc agtggtatga tcttggctca ctgcaaacct ttgcctccct ggtccaagtg   1380

attctcctgc ttcagcctcc aaaagtagct aggactacag ctaatcctag tgaatcctcc   1440

atgaggccat tgttctgaat ggaagaagag agatatatgc aataggaaaa ggtgacgtgg   1500

aatctatgag agtcccatgt ttatgtagca tattgtgcct actgtatcta ttcaggaggg   1560

gattcttaat ataagagata catttacaaa attgcttcca ttacctacaa acaccataaa   1620

gaaaagtaac agtgatgcat atggacagaa ctgcatcacc agaagttaga ggaggaaagc   1680

atttcctatc caactttaaa tgctgagaat gaataaccag gaaaaatggt acagaggaca   1740

aaataccaac aaaagtctcc aaaagtgatg tgaagaaaat aaggggctca tcattctaaa   1800

ttctgcagga gagcagtaga agaaatcaag ggaatcccac attatgtggg actctgcgac   1860

tgtattggac acatagaata atctaggata atctctctgt ctcaagatct tcaaatgaat   1920

cgcagctgta acgtcccttt tgccagggaa ggcaatatat tcacagattc tgaggattag   1980

gaatgagacc tccttggagc cattgtttaa cctttcatag gctggataat atagttttgc   2040

aaactcaatt tgggcagctg gacagtgatc aggcaacttt ccgagtccct gactcccacc   2100

tagactgaga ttccaatgct aggtgcccag aagtttccaa ccaatgcaaa ggtggcagct   2160

ggcaagggcc ctgtgcagca gtaaggcgag tcatagactg atgaggcaaa tcaccattgg   2220

gaatgagctc catttgccca caacagtgat cggctgatgg ctccaccctc tacttagtcg   2280

cttctgtttc ctgtcccatg gattcctcac cccacactaa tgcttccagg aacaacttct   2340

caaataaatc acttgcacat ttctagatga tatgaattat attcagacct gaagagagga   2400

cagaaaaatt ctggacttca aactcaatgc aatgattgga taagactttc ggagtaactt   2460

cttttgggat tgcgtaagag atcaagacta cagactttga ggtaaaaaca acctagattc   2520

gtgagaagag gaagagtaaa agaactgcag ctttcctccc actcttaagg tataaatatg   2580

aagtctaggt catttcgagt tggagaagcc ccagctactt cataagtgtg atgctagttt   2640

tgaatgtgca ttgagggaca gctggtgttg agaaaaaagg aaattacctt aataccaata   2700

atttcagcac agattgtcat gtggttggga aaatatttga tatgaagaca ttgaatccac   2760

cttctaaaga ataacaagat atattcatga atggaaggat ttggtagggt acatgaggac   2820

agatataaaa ctgcacaacc aatgttacac aaaggaggtt tattcttctt cacaagaaag   2880

tgatgtgtag agatattcac tgaattattg aagattatat gtggcagagt cagcttgggg   2940

atccaggttg tctaatccaa agattgttta accaagaaac aaggtcaagg catgttcttc   3000

gatgcttgtt cattaacagc tctgcgggtg atgctcctag agaggtctga tgtgttgtgt   3060

gatgttctca cacaaactat gttaattttt gatcagtgat tgtgagtttt aattgtgttg   3120

aggtaactag agatttgtta agtggacgtt acttcaaaaa ggtaagttga agcagtaaat   3180

gttaaaacca aggaatcccc caaattcttg ccctttattt tttgcatgtt aattccagaa   3240

aagaaaaaaa aaaaagcttg tgggttaacg tggtatttat gcaaggctgc caatgtaaat   3300

ataattctgt gatttaattt tttactggca tgacattata tatatgtata aaatgtgcat   3360

acataatata tacatatgta tatatgttat atattagatg tgtatgcata tataatatat   3420

attagatgta taaaatatat tacatatata ataaaatatt agatatgtat tatatagtag   3480

tatatataaa atatatacat atctaataat acattataga tcatgtatta atatatacat   3540

atatctagta tatacaatat atacatatct attatattta tacacacata catatacata   3600

tgtgtatgtg tatgtctgtg cctgtgtgtc tttttgtctt gcaagctcaa tctttaaaaa   3660

gaagagttcg aggagggatg gagaaggaag agagtgatta tatatacata tactgtccat   3720

gtttgcttag ctagtatgaa gcagaatctg gattcaaatt caagaagtct gattcccaaa   3780

cagccaccca attaggaccg ctttgaaaac tccgagtctt ctatttgata taagtatagc   3840

tcattgccat ggaaataaac atatgtttct tttttaaatt aaaaaaaata tttttatttt   3900

gttttcaaca tttagcattt ttttgcatca aagttctaag tagctgcatg tctgtttata   3960

atgtgtatat ttgttgtttg tttttctgtt ttgtttctgt atagtttctt tgtttgtatc   4020

actggtaatt taatccctca tgctatgctg tgggattatg tacaacaaca caacttctta   4080

gcctcttcaa accctttcac tgcaagctgc ttttttgtgc tttttgaaag aaaaggaaga   4140

aaaacacatt gcattttctt aagataaaat gatacctgct tcttcatttc ctcctactcc   4200

ttcctattat cttttgtaga aagaattgct gaatctattg atatgtaatt ttcatttaat   4260

tctccaacat cttattgcta tttaaaatgg tttaagaaaa ctggcttaat atagccaaga   4320

aaaattctat agtaatactt gtctgtaatt tctctatatt taaataaaat atcatttcta   4380

tcttggaggt ttgatttggc catttaaaaa tgctaatgtt ttattgtttt ttcaaaaaaa   4440

tactacatgc atgctcatag tataaacatc aatgtttcat taggatatat agtgaaaagt   4500

cagtaacttt acaacctctg tttcaaaccc aaccagtaat ttaagttgtt ttcataacaa   4560

agtgttatta tttatcttct aatacctata aaatatttat ttactcccca aattaaatag   4620

agtgttggtt cttcaatgaa ggtatgaagt tactttcaat taaatatgca gtttgattag   4680

aagaaaaaaa aatccatcag atctcagcca agctcttttg gatgattatt tttcttcaaa   4740

atcaaataca ctaaaatttc caaacagtaa cagttacaat gtttcagttt cttttaaggt   4800

agcctgaact gagacacatt aaggtttata tctaatttca tagttctgtt cagtaggaaa   4860

taagtaaatt agtttaaagg actgatccat atcaggagat caggactgga caaagtgtta   4920

atttatctac agattttacc aggcagattg ccaatatcca agttcattag acaggtccta   4980

ggactaataa gaactcttgg gggctacaat gtgaaatacc tgagtatatg agtcaggtaa   5040

agactttaga aagtttggct tctactctca tattcccagg agttgaatag attggagtgg   5100

aaaaaatgtg gtcaaaaact agtgattttg gattagaagt agggcataaa gctcctatta   5160

ttgcacttgg gcaatattaa ctggattgca agaaactgta atatgcagaa acagcatatt   5220

tcccttaggg agtacatttt gttaaactta gtattcttgc tacctgtttt gttacctaag   5280

cttaatggac ctggccctag actttagctt ggtgcatggt gaaaattgac cttaagcaac   5340

tgcagcattg tccaaatatt tggtttcaca tagaccagtt ttggttcttg tttctgtgtg   5400

actttgaggg gctctttaag aaatccaagg acaaggtgcc acatttatta aggccccgcc   5460

attcacaatg catgatgcta gagcctgaca gtgcaccatg ctagagactg aagagacata   5520

aaaaaaagaa aaggcagagt tcttgctatc aggttcttaa aattttcttt gttttggtta   5580

aattcttgat tggatttttt cactaaatgt ttggccctat taaaaataag taaagaaaaa   5640

atgaaggaag aatggaagag agggagaata ggaaatgaat gaaacaaagc caagtaagag   5700

atacgtctac tacagacctg caagttggca gtgcttgcag aagacagttg acatattcta   5760

gcctggttca cattttctgg ttaacttttg agcatagaat aaagaatata ataaaatgct   5820

tttttttttt tttgcacaat gaactttaaa caaatcagga gagtatattg gtaatttaga   5880

gaagtagcaa ttctcattaa atctgttttt cattgaatta tcatgccctt aaaattatat   5940

gatagattat tatcttcggt agtattagtt taaataagaa ttatatacaa ccaaaatatc   6000

agtaaggcta attctctgag accataagag aaccaagtca atatccccat agctacatca   6060

tattgatcat tcatttgatt taagaagaaa gaagacaaat atgttagtga aagggagaca   6120

aatgagtatg tgcctggcct ggccaattcc tgactcattt acagaggaag ctaatataac   6180

tctcttactc attttatggg aaatatgata gatctgatta tataatttat gcctcctttc   6240

agacttccta caccccacta attgtctctt cctttctttt ctccaccttt tgctcaggta   6300

tttggcagtt attgcacttt tttggatctt ttttttaagg atgttactat caatcttttg   6360

cctacatcta aatgacttac ctatgaagaa gatcccattt ttagccttaa tatttgcaaa   6420

ttacttgaga gatggagtct cactctatca cccaggctgg aggacagtgg cacgacctca   6480

gctccctgca acctccacct cccaggttac tgatggatcc gtcctaaatg ccatccatct   6540

caagacagag gcccacagaa gtcaatgtat cttcaagatg ggagtacctg gagatggctg   6600

tagagaccat gtagcaggaa atggtgacag agaagagctg ggcctctggt accaacatgc   6660

ttcccccccg ttacagctat gcgggctgat agtgacgcaa tgtgtggttt caatacttca   6720

tagtgtctta cttcacctca gtataaagta ctttgaaagc atcaaggaaa tggtcctcaa   6780

aaaaggctta tccagtcagg acatctggtg ctggctctgg aatgagtgga tgaagataag   6840

gccttccagt atggaggtga taaaaatcag ggaagacagg taatcacaat ggatgacaga   6900

ccaggattcc cagatatctt ggcatggctg gaacaatgta cagatcaaac catgtaaaac   6960

ttaatgggta taaaccaact cttcactttg gtctaaaaaa gtccatttgc atggcttcta   7020

gttaaaggtg gacaggctca ctttagaatc ctattatata caaaggattt agggggttta   7080

gttcacaatg tgctaaagcc atctcacagt gaccatggta tgagctgtgt gatttggttt   7140

aaatataata gagaatgaag gacaaggttg agggtggtgg ttacagtcct gcctgattct   7200

gtagtgctca ggtgaccttt gaagaatgaa gaaagaagtc aaaaccccac actattaaga   7260

cattggaaga ctgggaatgt ttattttctg aagaataaaa gatgtaggaa ac           7312


<210>  9682
<211>  180
<212>  PRT
<213>  Homosapiens

<400>  9682

Met Leu Leu Ser Ile Phe Cys Leu His Leu Asn Asp Leu Pro Met Lys 
1               5                   10                  15      


Lys Ile Pro Phe Leu Ala Leu Ile Phe Ala Asn Tyr Leu Arg Asp Gly 
            20                  25                  30          


Val Ser Leu Tyr His Pro Gly Trp Arg Thr Val Ala Arg Pro Gln Leu 
        35                  40                  45              


Pro Ala Thr Ser Thr Ser Gln Val Thr Asp Gly Ser Val Leu Asn Ala 
    50                  55                  60                  


Ile His Leu Lys Thr Glu Ala His Arg Ser Gln Cys Ile Phe Lys Met 
65                  70                  75                  80  


Gly Val Pro Gly Asp Gly Cys Arg Asp His Val Ala Gly Asn Gly Asp 
                85                  90                  95      


Arg Glu Glu Leu Gly Leu Trp Tyr Gln His Ala Ser Pro Pro Leu Gln 
            100                 105                 110         


Leu Cys Gly Leu Ile Val Thr Gln Cys Val Val Ser Ile Leu His Ser 
        115                 120                 125             


Val Leu Leu His Leu Ser Ile Lys Tyr Phe Glu Ser Ile Lys Glu Met 
    130                 135                 140                 


Val Leu Lys Lys Gly Leu Ser Ser Gln Asp Ile Trp Cys Trp Leu Trp 
145                 150                 155                 160 


Asn Glu Trp Met Lys Ile Arg Pro Ser Ser Met Glu Val Ile Lys Ile 
                165                 170                 175     


Arg Glu Asp Arg 
            180 


<210>  9683
<211>  742
<212>  DNA
<213>  Homosapiens

<400>  9683
agtagtgatc cacctgcctc ggcctcccaa agtgctggga ttacaggcgt gagccaccgc     60

gtccagccaa ttggtgggtt cctggtctca ctgacttcaa gaatgaagcc acggaccctc    120

gcaatgctgt tacgaacttc ccttagaatc aacccatttg tgaaacacca cattaataag    180

agcagtatct ttggagattg gagagtccac caaggatgcc cactggctcc ctacaaagtt    240

ttttatgtga ggactcggtc tcaggctcag aagtggaaga gatgtgcctt gactcagatg    300

agactttgga cttggacttt tgagttaatt ctggaatgag ttaaaacttt aggggactgt    360

tgggaaggca ttattgtgtt ttaaatgtga aaagaacatg aggtatggga ggggtcaggg    420

gtggaatgat atggtttggc tctgtgtccc cacccaaatc tcatgtcaaa ttttaatccc    480

cagtgttggt ggaggagcct agtgagaggt gactgaatca caggggcaga cttcctcctt    540

gtttctcttg tgatagtgag tgagttctca tgaactctgg ttgttgtaaa gtgtgtggca    600

cctttccctt cactctctct cttcctcctg ctcttgccgt gagaataagt gcatgcttcc    660

cctcctgcca tgggaataag tgcatgcttc ccctcctgcc atgagaacaa gtgcatgctt    720

ctccttttgc cttctaccat gt                                             742


<210>  9684
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  9684

Met Lys Pro Arg Thr Leu Ala Met Leu Leu Arg Thr Ser Leu Arg Ile 
1               5                   10                  15      


Asn Pro Phe Val Lys His His Ile Asn Lys Ser Ser Ile Phe Gly Asp 
            20                  25                  30          


Trp Arg Val His Gln Gly Cys Pro Leu Ala Pro Tyr Lys Val Phe Tyr 
        35                  40                  45              


Val Arg Thr Arg Ser Gln Ala Gln Lys Trp Lys Arg Cys Ala Leu Thr 
    50                  55                  60                  


Gln Met Arg Leu Trp Thr Trp Thr Phe Glu Leu Ile Leu Glu 
65                  70                  75              


<210>  9685
<211>  606
<212>  DNA
<213>  Homosapiens

<400>  9685
ggcactggaa catcttatgg ctgcctctct gggatcatta ctgagatcaa tgactccttc     60

cctcatgtct tccacattca ggaagtttaa catctgtgaa gctgctcatc tgacggcccc    120

agagattaaa gtctgtttat tggcataggg gagaggctga ggcagcctaa aatctaggct    180

aatattatca cctttgccat gcatgttttt ccacaatctg gagaccggtg tacataaaga    240

aaaagcaaca tctgtgatac tccttatact actttgtgtt tcagtgctca actttcaaca    300

ttattattat tatttctaag aaaatcaatg gaaatactgc aaagcagaat attacgatgt    360

aagtttgatc actgcgaggc taggaaataa tgagaaaact cctgccatga atagaattct    420

gccaagcagg aagaatattt gctgaagtgg aagtggtggg aatctcacga agaaggggaa    480

cagccagtac cagccattac aaaaggcgga tttgaaaatg tttaaaatat ttttcctcag    540

acttggctac aaattaaaat aatccaggga gtttgttttt ttcgataaag tattcataga    600

accctt                                                               606


<210>  9686
<211>  43
<212>  PRT
<213>  Homosapiens

<400>  9686

Met Ala Ala Ser Leu Gly Ser Leu Leu Arg Ser Met Thr Pro Ser Leu 
1               5                   10                  15      


Met Ser Ser Thr Phe Arg Lys Phe Asn Ile Cys Glu Ala Ala His Leu 
            20                  25                  30          


Thr Ala Pro Glu Ile Lys Val Cys Leu Leu Ala 
        35                  40              


<210>  9687
<211>  749
<212>  DNA
<213>  Homosapiens

<400>  9687
tgctgccatc cacctaagat gtaacttgcc tttcctcgcc ttccaccatg attgtgaagc     60

ctccacaacc atgtagaact atgaggaaac agaggcccaa aaagttgagc aacatgcaaa    120

cctcatacaa ttaattactg gtaaagccag tattcaagta aaaagtgaag agtaactaaa    180

ttcagaaaaa aaaatcacag acttattaga aagatttgga tgagttatga ggcttgaaat    240

agaatcgtaa ttgtagaaat gaaaaaaagg atgatgtggg ccggtcgtgg tggctcactc    300

ctgtaatccc agcactttgg gagtgagagg caggtggatc acgaggtcgg gagatggcga    360

ccatcctggc taacacaatg aaacctagtc tccactaaaa atacaaaaaa ttagccaggc    420

gtggtggcgg acgcctgtgg tcccagctac tcgggaggct gaggcaggag aatggcatga    480

acctgggagg cggagcttgc agtgagccaa gattgtgcca ctgcactcca gactgggcaa    540

cagagcgaga ctctgtctca aaaaggaaaa aaaagaaaaa gaaaaaaagg atgatgtgaa    600

agagctttat ggttaaaata tgcaggactt gtcagtaaaa tgggtataaa agacaataaa    660

gtatgaagat tcaaaatgtg tcggaaaatc gttacaccat tagacaaaat ggaaaaacca    720

taacgtagga aagagaaggc agcaaattt                                      749


<210>  9688
<211>  40
<212>  PRT
<213>  Homosapiens

<400>  9688

Met Asn Leu Gly Gly Gly Ala Cys Ser Glu Pro Arg Leu Cys His Cys 
1               5                   10                  15      


Thr Pro Asp Trp Ala Thr Glu Arg Asp Ser Val Ser Lys Arg Lys Lys 
            20                  25                  30          


Lys Lys Lys Lys Lys Arg Met Met 
        35                  40  


<210>  9689
<211>  3975
<212>  DNA
<213>  Homosapiens

<400>  9689
ctgggtcctg tgtgtgccac aggggtgggg tgtccagcga gcggtctcct cctcctgcta     60

gtgctgctgc ggcgtcccgc ggcctccccg agtcgggcgg gaggggagag cgggtgtgga    120

tttgtcttga cggtaattgt tgcgtttcca cgtctcggag gcctgcgcgc tgggttgctc    180

cttcttcggg agcgagctgt tctcagcgat cccactccca gccggggctc cccacacaca    240

ctgggctgcg tgcgtgtgga gtgggacccg cgcacacgcg tgtctctgga cagctacggc    300

gccgaaagaa ctaaaattcc agatggcaaa ctcaatgaat ggcagaaacc ctggtggtcg    360

aggaggaaat ccccgaaaag gtcgaatttt gggtattatt gatgctattc aggatgcagt    420

tggaccccct aagcaagctg ccgcagatcg caggaccgtg gagaagactt ggaagctcat    480

ggacaaagtg gtaagactgt gccaaaatcc caaacttcag ttgaaaaata gcccaccata    540

tatacttgat attttgcctg atacatatca gcatttacga cttatattga gtaaatatga    600

tgacaaccag aaacttgccc aactcagtga gaatgagtac tttaaaatct acattgatag    660

ccttatgaaa aagtcaaaac gggcaataag actctttaaa gaaggcaagg agagaatgta    720

tgaagaacag tcacaggaca gacgaaatct cacaaaactg tcccttatct tcagtcacat    780

gctggcagaa atcaaagcaa tctttcccaa tggtcaattc cagggagata actttcgtat    840

cacaaaagca gatgctgctg aattctggag aaagtttttt ggagacaaaa ctatcgtacc    900

atggaaagta ttcagacagt gccttcatga ggtccaccag attagctctg gcctggaagc    960

aatggctcta aaatcaacaa ttgatttaac ttgcaatgat tacatttcag tttttgaatt   1020

tgatattttt accaggctgt ttcagccttg gggctctatt ttgcggaatt ggaatttctt   1080

agctgtgaca catccaggtt acatggcatt tctcacatat gatgaagtta aagcacgact   1140

acagaaatat agcaccaaac ccggaagcta tattttccgg ttaagttgca ctcgattggg   1200

acagtgggcc attggctatg tgactgggga tgggaatatc ttacagacca tacctcataa   1260

caagccctta tttcaagccc tgattgatgg cagcagggaa ggattttatc tttatcctga   1320

tgggaggagt tataatcctg atttaactgg attatgtgaa cctacacctc atgaccatat   1380

aaaagttaca caggaacaat atgaattata ttgtgaaatg ggctccactt ttcagctctg   1440

taagatttgt gcagagaatg acaaagatgt caagattgag ccttgtgggc atttgatgtg   1500

cacctcttgc cttacggcat ggcaggagtc ggatggtcag ggctgccctt tctgtcgttg   1560

tgaaataaaa ggaactgagc ccataatcgt ggaccccttt gatccaagag atgaaggctc   1620

caggtgttgc agcatcattg acccctttgg catgccgatg ctagacttgg acgacgatga   1680

tgatcgtgag gagtccttga tgatgaatcg gttggcaaac gtccgaaagt gcactgacag   1740

gcagaactca ccagtcacat caccaggatc ctctcccctt gcccagagaa gaaagccaca   1800

gcctgaccca ctccagatcc cacatctaag cctgccaccc gtgcctcctc gcctggatct   1860

aattcagaaa ggcatagtta gatctccctg tggcagccca acgggttcac caaagtcttc   1920

tccttgcatg gtgagaaaac aagataaacc actcccagca ccacctcctc ccttaagaga   1980

tcctcctcca ccgccacctg aaagacctcc accaatccca ccagacaata gactgagtag   2040

acacatccat catgtggaaa gcgtgccttc cagagacccg ccaatgcctc ttgaagcatg   2100

gtgccctcgg gatgtgtttg ggactaatca gcttgtggga tgtcgactcc taggggaggg   2160

ctctccaaaa cctggaatca cagcgagttc aaatgtcaat ggaaggcaca gtagagtggg   2220

ctctgaccca gtgcttatgc ggaaacacag acgccatgat ttgcctttag aaggagctaa   2280

ggtcttttcc aatggtcacc ttggaagtga agaatatgat gttcctcccc ggctttctcc   2340

tcctcctcca gttaccaccc tcctccctag cataaagtgt actggtccgt tagcaaattc   2400

tctttcagag aaaacaagag acccagtaga ggaagatgat gatgaataca agattccttc   2460

atcccaccct gtttccctga attcacaacc atctcattgt cataatgtaa aacctcctgt   2520

tcggtcttgt gataatggtc actgtatgct gaatggaaca catggtccat cttcagagaa   2580

gaaatcaaac atccctgact taagcatata tttaaaggga gatgtttttg attcagcctc   2640

tgatcccgtg ccattaccac ctgccaggcc tccaactcgg gacaatccaa agcatggttc   2700

ttcactcaac aggacgccct ctgattatga tcttctcatc cctccattag gtgaagatgc   2760

ttttgatgcc ctccctccat ctctcccacc tcccccacct cctgcaaggc atagtctcat   2820

tgaacattca aaacctcctg gctccagtag ccggccatcc tcaggacagg atctttttct   2880

tcttccttca gatccctttg ttgatctagc aagtggccaa gttcctttgc ctcctgctag   2940

aaggttacca ggtgaaaatg tcaaaactaa cagaacatca caggactatg atcagcttcc   3000

ttcatgttca gatggttcac aggcaccagc cagaccccct aaaccacgac cgcgcaggac   3060

tgcaccagaa attcaccaca gaaaacccca tgggcctgag gcggcattgg aaaatgtcga   3120

tgcaaaaatt gcaaaactca tgggagaggg ttatgccttt gaagaggtga agagagcctt   3180

agagatagcc cagaataatg tcgaagttgc ccggagcatc ctccgagaat ttgccttccc   3240

tcctccagta tccccacgtc taaatctata gcagccagaa ctgtagacac caaaatggaa   3300

agcaatcgat gtattccaag agtgtggaaa taaagagaac tgagatggaa ttcaagagag   3360

aagtgtctcc tcctcgtgta gcagcttgag aagaggcttg ggagtgcagc ttctcaaagg   3420

agaccgatgc ttgctcagga tgtcgacagc tgtggcttcc ttgtttttgc tagccatatt   3480

tttaaatcag ggttgaactg acaaaaataa tttaaagacg tttacttccc ttgaactttg   3540

aacctgtgaa atgctttacc ttgtttacag tttggcaaag ttgcagtttg ttcttgtttt   3600

tagtttagtt ttgttttggt gttttgatac ctgtactgtg ttcttcacag accctttgta   3660

gcgtggtcag gtctgctgta acatttccca ccaactctct tgctgtccac atcaacagct   3720

aaatcattta ttcatatgga tctctaccat ccccatgcct tgcccaggtc cagttccatt   3780

tctctcattc acaagatgct ttgaaggttc tgattttcaa ctgatcaaac taatgcaaaa   3840

aaaaaaaagt atgtattctt cactactgag tttcttcttt ggaaaccatc actattgaga   3900

gatgggaaaa acctgaatgt ataaagcatt tatttgtcaa taaactgcct tttgtaaggg   3960

gttttcacat aacat                                                    3975


<210>  9690
<211>  982
<212>  PRT
<213>  Homosapiens

<400>  9690

Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn 
1               5                   10                  15      


Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala 
            20                  25                  30          


Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Thr Val Glu Lys 
        35                  40                  45              


Thr Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys 
    50                  55                  60                  


Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp 
65                  70                  75                  80  


Thr Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln 
                85                  90                  95      


Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp 
            100                 105                 110         


Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly 
        115                 120                 125             


Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Thr 
    130                 135                 140                 


Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile 
145                 150                 155                 160 


Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Thr Lys Ala 
                165                 170                 175     


Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Thr Ile Val 
            180                 185                 190         


Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser 
        195                 200                 205             


Ser Gly Leu Glu Ala Met Ala Leu Lys Ser Thr Ile Asp Leu Thr Cys 
    210                 215                 220                 


Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Thr Arg Leu Phe 
225                 230                 235                 240 


Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Thr 
                245                 250                 255     


His Pro Gly Tyr Met Ala Phe Leu Thr Tyr Asp Glu Val Lys Ala Arg 
            260                 265                 270         


Leu Gln Lys Tyr Ser Thr Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser 
        275                 280                 285             


Cys Thr Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Thr Gly Asp Gly 
    290                 295                 300                 


Asn Ile Leu Gln Thr Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu 
305                 310                 315                 320 


Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser 
                325                 330                 335     


Tyr Asn Pro Asp Leu Thr Gly Leu Cys Glu Pro Thr Pro His Asp His 
            340                 345                 350         


Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser 
        355                 360                 365             


Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys 
    370                 375                 380                 


Ile Glu Pro Cys Gly His Leu Met Cys Thr Ser Cys Leu Thr Ala Trp 
385                 390                 395                 400 


Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys 
                405                 410                 415     


Gly Thr Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly 
            420                 425                 430         


Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp 
        435                 440                 445             


Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu 
    450                 455                 460                 


Ala Asn Val Arg Lys Cys Thr Asp Arg Gln Asn Ser Pro Val Thr Ser 
465                 470                 475                 480 


Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro 
                485                 490                 495     


Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp 
            500                 505                 510         


Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Thr Gly 
        515                 520                 525             


Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu 
    530                 535                 540                 


Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu 
545                 550                 555                 560 


Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His 
                565                 570                 575     


His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala 
            580                 585                 590         


Trp Cys Pro Arg Asp Val Phe Gly Thr Asn Gln Leu Val Gly Cys Arg 
        595                 600                 605             


Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Thr Ala Ser Ser Asn 
    610                 615                 620                 


Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg 
625                 630                 635                 640 


Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser 
                645                 650                 655     


Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser 
            660                 665                 670         


Pro Pro Pro Pro Val Thr Thr Leu Leu Pro Ser Ile Lys Cys Thr Gly 
        675                 680                 685             


Pro Leu Ala Asn Ser Leu Ser Glu Lys Thr Arg Asp Pro Val Glu Glu 
    690                 695                 700                 


Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn 
705                 710                 715                 720 


Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys 
                725                 730                 735     


Asp Asn Gly His Cys Met Leu Asn Gly Thr His Gly Pro Ser Ser Glu 
            740                 745                 750         


Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Asp Val 
        755                 760                 765             


Phe Asp Ser Ala Ser Asp Pro Val Pro Leu Pro Pro Ala Arg Pro Pro 
    770                 775                 780                 


Thr Arg Asp Asn Pro Lys His Gly Ser Ser Leu Asn Arg Thr Pro Ser 
785                 790                 795                 800 


Asp Tyr Asp Leu Leu Ile Pro Pro Leu Gly Glu Asp Ala Phe Asp Ala 
                805                 810                 815     


Leu Pro Pro Ser Leu Pro Pro Pro Pro Pro Pro Ala Arg His Ser Leu 
            820                 825                 830         


Ile Glu His Ser Lys Pro Pro Gly Ser Ser Ser Arg Pro Ser Ser Gly 
        835                 840                 845             


Gln Asp Leu Phe Leu Leu Pro Ser Asp Pro Phe Val Asp Leu Ala Ser 
    850                 855                 860                 


Gly Gln Val Pro Leu Pro Pro Ala Arg Arg Leu Pro Gly Glu Asn Val 
865                 870                 875                 880 


Lys Thr Asn Arg Thr Ser Gln Asp Tyr Asp Gln Leu Pro Ser Cys Ser 
                885                 890                 895     


Asp Gly Ser Gln Ala Pro Ala Arg Pro Pro Lys Pro Arg Pro Arg Arg 
            900                 905                 910         


Thr Ala Pro Glu Ile His His Arg Lys Pro His Gly Pro Glu Ala Ala 
        915                 920                 925             


Leu Glu Asn Val Asp Ala Lys Ile Ala Lys Leu Met Gly Glu Gly Tyr 
    930                 935                 940                 


Ala Phe Glu Glu Val Lys Arg Ala Leu Glu Ile Ala Gln Asn Asn Val 
945                 950                 955                 960 


Glu Val Ala Arg Ser Ile Leu Arg Glu Phe Ala Phe Pro Pro Pro Val 
                965                 970                 975     


Ser Pro Arg Leu Asn Leu 
            980         


<210>  9691
<211>  2093
<212>  DNA
<213>  Homosapiens

<400>  9691
ggtgtccagc gagcggtctc ctcctcctgc tagtgctgct gcggcgtccc gcggcctccc     60

cgagtcgggc gggaggggag agcgggtgtg gatttgtctt gacggtaatt gttgcgtttc    120

cacgtctcgg aggcctgcgc gctgggttgc tccttcttcg ggagcgagct gttctcagcg    180

atcccactcc cagccggggc tccccacaca cactgggctg cgtgcgtgtg gagtgggacc    240

cgcgcacacg cgtgtctctg gacagctacg gcgccgaaag aactaaaatt ccagatggca    300

aactcaatga atggcagaaa ccctggtggt cgaggaggaa atccccgaaa aggtcgaatt    360

ttgggtatta ttgatgctat tcaggatgca gttggacccc ctaagcaagc tgccgcagat    420

cgcaaaacct ggaatcacag cgagttcaaa tgtcaatgga aggcacagta gagtgggctc    480

tgacccagtg cttatgcgga aacacagacg ccatgatttg cctttagaag gagctaaggt    540

cttttccaat ggtcaccttg gaagtgaaga atatgatgtt cctccccggc tttctcctcc    600

tcctccagtt accaccctcc tccctagcat aaagtgtact ggtccgttag caaattctct    660

ttcagagaaa acaagagacc cagtagagga agatgatgat gaatacaaga ttccttcatc    720

ccaccctgtt tccctgaatt cacaaccatc tcattgtcat aatgtaaaac ctcctgttcg    780

gtcttgtgat aatggtcact gtatgctgaa tggaacacat ggtccatctt cagagaagaa    840

atcaaacatc cctgacttaa gcatatattt aaagggagat gtttttgatt cagcctctga    900

tcccgtgcca ttaccacctg ccaggcctcc aactcgggac aatccaaagc atggttcttc    960

actcaacagg acgccctctg attatgatct tctcatccct ccattaggtg aagatgcttt   1020

tgatgccctc cctccatctc tcccacctcc cccacctcct gcaaggcata gtctcattga   1080

acattcaaaa cctcctggct ccagtagccg gccatcctca ggacaggatc tttttcttct   1140

tccttcagat ccctttgttg atctagcaag tggccaagtt cctttgcctc ctgctagaag   1200

gttaccaggt gaaaatgtca aaactaacag aacatcacag gactatgatc agcttccttc   1260

atgttcagat ggttcacagg caccagccag accccctaaa ccacgaccgc gcaggactgc   1320

accagaaatt caccacagaa aaccccatgg gcctgaggcg gcattggaaa atgtcgatgc   1380

aaaaattgca aaactcatgg gagagggtta tgcctttgaa gaggtgaaga gagccttaga   1440

gatagcccag aataatgtcg aagttgcccg gagcatcctc cgagaatttg ccttccctcc   1500

tccagtatcc ccacgtctaa atctatagca gccagaactg tagacaccaa aatggaaagc   1560

aatcgatgta ttccaagagt gtggaaataa agagaactga gatggaattc aagagagaag   1620

tgtctcctcc tcgtgtagca gcttgagaag aggcttggga gtgcagcttc tcaaaggaga   1680

ccgatgcttg ctcaggatgt cgacagctgt ggcttccttg tttttgctag ccatattttt   1740

aaatcagggt tgaactgaca aaaataattt aaagacgttt acttcccttg aactttgaac   1800

ctgtgaaatg ctttaccttg tttacagttt ggcaaagttg cagtttgttc ttgtttttag   1860

tttagttttg ttttggtgtt ttgatacctg tactgtgttc ttcacagacc ctttgtagcg   1920

tggtcaggtc tgctgtaaca tttcccacca actctcttgc tgtccacatc aacagctaaa   1980

tcatttattc atatggatct ctaccatccc catgccttgc ccaggtccag ttccatttct   2040

ctcattcaca agatgctttg aaggttctga ttttcaactg atcaaactaa tgc          2093


<210>  9692
<211>  405
<212>  PRT
<213>  Homosapiens

<400>  9692

Met Ala Glu Thr Leu Val Val Glu Glu Glu Ile Pro Glu Lys Val Glu 
1               5                   10                  15      


Phe Trp Val Leu Leu Met Leu Phe Arg Met Gln Leu Asp Pro Leu Ser 
            20                  25                  30          


Lys Leu Pro Gln Ile Ala Lys Pro Gly Ile Thr Ala Ser Ser Asn Val 
        35                  40                  45              


Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg Lys 
    50                  55                  60                  


His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser Asn 
65                  70                  75                  80  


Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser Pro 
                85                  90                  95      


Pro Pro Pro Val Thr Thr Leu Leu Pro Ser Ile Lys Cys Thr Gly Pro 
            100                 105                 110         


Leu Ala Asn Ser Leu Ser Glu Lys Thr Arg Asp Pro Val Glu Glu Asp 
        115                 120                 125             


Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn Ser 
    130                 135                 140                 


Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys Asp 
145                 150                 155                 160 


Asn Gly His Cys Met Leu Asn Gly Thr His Gly Pro Ser Ser Glu Lys 
                165                 170                 175     


Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Asp Val Phe 
            180                 185                 190         


Asp Ser Ala Ser Asp Pro Val Pro Leu Pro Pro Ala Arg Pro Pro Thr 
        195                 200                 205             


Arg Asp Asn Pro Lys His Gly Ser Ser Leu Asn Arg Thr Pro Ser Asp 
    210                 215                 220                 


Tyr Asp Leu Leu Ile Pro Pro Leu Gly Glu Asp Ala Phe Asp Ala Leu 
225                 230                 235                 240 


Pro Pro Ser Leu Pro Pro Pro Pro Pro Pro Ala Arg His Ser Leu Ile 
                245                 250                 255     


Glu His Ser Lys Pro Pro Gly Ser Ser Ser Arg Pro Ser Ser Gly Gln 
            260                 265                 270         


Asp Leu Phe Leu Leu Pro Ser Asp Pro Phe Val Asp Leu Ala Ser Gly 
        275                 280                 285             


Gln Val Pro Leu Pro Pro Ala Arg Arg Leu Pro Gly Glu Asn Val Lys 
    290                 295                 300                 


Thr Asn Arg Thr Ser Gln Asp Tyr Asp Gln Leu Pro Ser Cys Ser Asp 
305                 310                 315                 320 


Gly Ser Gln Ala Pro Ala Arg Pro Pro Lys Pro Arg Pro Arg Arg Thr 
                325                 330                 335     


Ala Pro Glu Ile His His Arg Lys Pro His Gly Pro Glu Ala Ala Leu 
            340                 345                 350         


Glu Asn Val Asp Ala Lys Ile Ala Lys Leu Met Gly Glu Gly Tyr Ala 
        355                 360                 365             


Phe Glu Glu Val Lys Arg Ala Leu Glu Ile Ala Gln Asn Asn Val Glu 
    370                 375                 380                 


Val Ala Arg Ser Ile Leu Arg Glu Phe Ala Phe Pro Pro Pro Val Ser 
385                 390                 395                 400 


Pro Arg Leu Asn Leu 
                405 


<210>  9693
<211>  3785
<212>  DNA
<213>  Homosapiens

<400>  9693
ctgggtcctg tgtgtgccac aggggtgggg tgtccagcga gcggtctcct cctcctgcta     60

gtgctgctgc ggcgtcccgc ggcctccccg agtcgggcgg gaggggagag cgggtgtgga    120

tttgtcttga cggtaattgt tgcgtttcca cgtctcggag gcctgcgcgc tgggttgctc    180

cttcttcggg agcgagctgt tctcagcgat cccactccca gccggggctc cccacacaca    240

ctgggctgcg tgcgtgtgga gtgggacccg cgcacacgcg tgtctctgga cagctacggc    300

gccgaaagaa ctaaaattcc agatggcaaa ctcaatgaat ggcagaaacc ctggtggtcg    360

aggaggaaat ccccgaaaag gtcgaatttt gggtattatt gatgctattc aggatgcagt    420

tggaccccct aagcaagctg ccgcagatcg caggaccgtg gagaagactt ggaagctcat    480

ggacaaagtg gtaagactgt gccaaaatcc caaacttcag ttgaaaaata gcccaccata    540

tatacttgat attttgcctg atacatatca gcatttacga cttatattga gtaaatatga    600

tgacaaccag aaacttgccc aactcagtga gaatgagtac tttaaaatct acattgatag    660

ccttatgaaa aagtcaaaac gggcaataag actctttaaa gaaggcaagg agagaatgta    720

tgaagaacag tcacaggaca gacgaaatct cacaaaactg tcccttatct tcagtcacat    780

gctggcagaa atcaaagcaa tctttcccaa tggtcaattc cagggagata actttcgtat    840

cacaaaagca gatgctgctg aattctggag aaagtttttt ggagacaaaa ctatcgtacc    900

atggaaagta ttcagacagt gccttcatga ggtccaccag attagctctg gcctggaagc    960

aatggctcta aaatcaacaa ttgatttaac ttgcaatgat tacatttcag tttttgaatt   1020

tgatattttt accaggctgt ttcagccttg gggctctatt ttgcggaatt ggaatttctt   1080

agctgtgaca catccaggtt acatggcatt tctcacatat gatgaagtta aagcacgact   1140

acagaaatat agcaccaaac ccggaagcta tattttccgg ttaagttgca ctcgattggg   1200

acagtgggcc attggctatg tgactgggga tgggaatatc ttacagacca tacctcataa   1260

caagccctta tttcaagccc tgattgatgg cagcagggaa ggattttatc tttatcctga   1320

tgggaggagt tataatcctg atttaactgg attatgtgaa cctacacctc atgaccatat   1380

aaaagttaca caggaacaat atgaattata ttgtgaaatg ggctccactt ttcagctctg   1440

taagatttgt gcagagaatg acaaagatgt caagattgag ccttgtgggc atttgatgtg   1500

cacctcttgc cttacggcat ggcaggagtc ggatggtcag ggctgccctt tctgtcgttg   1560

tgaaataaaa ggaactgagc ccataatcgt ggaccccttt gatccaagag atgaaggctc   1620

caggtgttgc agcatcattg acccctttgg catgccgatg ctagacttgg acgacgatga   1680

tgatcgtgag gagtccttga tgatgaatcg gttggcaaac gtccgaaagt gcactgacag   1740

gcagaactca ccagtcacat caccaggatc ctctcccctt gcccagagaa gaaagccaca   1800

gcctgaccca ctccagatcc cacatctaag cctgccaccc gtgcctcctc gcctggatct   1860

aattcagaaa ggcatagtta gatctccctg tggcagccca acgggttcac caaagtcttc   1920

tccttgcatg gtgagaaaac aagataaacc actcccagca ccacctcctc ccttaagaga   1980

tcctcctcca ccgccacctg aaagacctcc accaatccca ccagacaata gactgagtag   2040

acacatccat catgtggaaa gcgtgccttc cagagacccg ccaatgcctc ttgaagcatg   2100

gtgccctcgg gatgtgtttg ggactaatca gcttgtggga tgtcgactcc taggggaggg   2160

ctctccaaaa cctggaatca cagcgagttc aaatgtcaat ggaaggcaca gtagagtggg   2220

ctctgaccca gtgcttatgc ggaaacacag acgccatgat ttgcctttag aaggagctaa   2280

ggtcttttcc aatggtcacc ttggaagtga agaatatgat gttcctcccc ggctttctcc   2340

tcctcctcca gttaccaccc tcctccctag cataaagtgt actggtccgt tagcaaattc   2400

tctttcagag aaaacaagag acccagtaga ggaagatgat gatgaataca agattccttc   2460

atcccaccct gtttccctga attcacaacc atctcattgt cataatgtaa aacctcctgt   2520

tcggtcttgt gataatggtc actgtatgct gaatggaaca catggtccat cttcagagaa   2580

gaaatcaaac atccctgact taagcatata tttaaaggga gatgtttttg attcagcctc   2640

tgatcccgtg ccattaccac ctgccaggcc tccaactcgg gacaatccaa agcatggttc   2700

ttcactcaac aggacgccct ctgattatga tcttctcatc cctccattag gttgaaacct   2760

ttaaaaaagt tttgaacaac ccacccctcc ttcttttaat ttcagaattt tcagaattca   2820

gagttcagta taacacagac tcactgggtt gtgaatttgc ctgaaatttg aatgggttct   2880

ccaggtgccg gtgactccca agttcacgag accattactc catgtagatg attaaggtag   2940

tagtgtagta gttgggcatc agtcaggttt taagcaagtt gttttgtcca tactaaatgt   3000

agtctaaaaa cacatgagag ctttgtgctc tagtagtttt gaagtgatga cttgaagtgt   3060

tgagattttc tttaagtata ataattctta ataaatatga acttgctttt cttgcagcat   3120

gagcaccagt tccacttacg ctaattaaat tatgcaaaat taaatagttg tatgtagaga   3180

actgataata aattctgttt tattctaatc attacaactg taacacattc aaaaaaatct   3240

caatttcctt gtttcaaatt ataataatga agaaacatcc tatgtgtatt tttgtttgta   3300

tccacaggtg aaggtatatg taggtgtgtg tatatgttga agttggctgg tgccactgtc   3360

actgttaatt tcattaattc taattaggaa gcatctcacc ctgtttttag aagacagaat   3420

gtctgcacac cttacataac gcttcacaat aacaagtcac tgtaacataa aataatatat   3480

gatgaaagtc aatttacaag cttttctgaa ctggctgtta ggccaccaga aatacgaaat   3540

gaacctttcc attttctcac aagtaccact gactagtatt ttgaatgaca caattgcagt   3600

atcttttgct cctgttctct ctgtagttca ggactttatt ctcacctaca tcaattacaa   3660

aaggctccta actctgttac ctacagtctt tctctccctt ccacttcttc ctgcacactt   3720

gtttttgaca tattacccag atcttcatca cctggataag cattgttcaa taaagctttc   3780

tgtgg                                                               3785


<210>  9694
<211>  810
<212>  PRT
<213>  Homosapiens

<400>  9694

Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn 
1               5                   10                  15      


Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala 
            20                  25                  30          


Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Thr Val Glu Lys 
        35                  40                  45              


Thr Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys 
    50                  55                  60                  


Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp 
65                  70                  75                  80  


Thr Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln 
                85                  90                  95      


Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp 
            100                 105                 110         


Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly 
        115                 120                 125             


Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Thr 
    130                 135                 140                 


Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile 
145                 150                 155                 160 


Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Thr Lys Ala 
                165                 170                 175     


Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Thr Ile Val 
            180                 185                 190         


Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser 
        195                 200                 205             


Ser Gly Leu Glu Ala Met Ala Leu Lys Ser Thr Ile Asp Leu Thr Cys 
    210                 215                 220                 


Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Thr Arg Leu Phe 
225                 230                 235                 240 


Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Thr 
                245                 250                 255     


His Pro Gly Tyr Met Ala Phe Leu Thr Tyr Asp Glu Val Lys Ala Arg 
            260                 265                 270         


Leu Gln Lys Tyr Ser Thr Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser 
        275                 280                 285             


Cys Thr Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Thr Gly Asp Gly 
    290                 295                 300                 


Asn Ile Leu Gln Thr Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu 
305                 310                 315                 320 


Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser 
                325                 330                 335     


Tyr Asn Pro Asp Leu Thr Gly Leu Cys Glu Pro Thr Pro His Asp His 
            340                 345                 350         


Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser 
        355                 360                 365             


Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys 
    370                 375                 380                 


Ile Glu Pro Cys Gly His Leu Met Cys Thr Ser Cys Leu Thr Ala Trp 
385                 390                 395                 400 


Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys 
                405                 410                 415     


Gly Thr Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly 
            420                 425                 430         


Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp 
        435                 440                 445             


Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu 
    450                 455                 460                 


Ala Asn Val Arg Lys Cys Thr Asp Arg Gln Asn Ser Pro Val Thr Ser 
465                 470                 475                 480 


Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro 
                485                 490                 495     


Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp 
            500                 505                 510         


Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Thr Gly 
        515                 520                 525             


Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu 
    530                 535                 540                 


Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu 
545                 550                 555                 560 


Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His 
                565                 570                 575     


His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala 
            580                 585                 590         


Trp Cys Pro Arg Asp Val Phe Gly Thr Asn Gln Leu Val Gly Cys Arg 
        595                 600                 605             


Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Thr Ala Ser Ser Asn 
    610                 615                 620                 


Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg 
625                 630                 635                 640 


Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser 
                645                 650                 655     


Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser 
            660                 665                 670         


Pro Pro Pro Pro Val Thr Thr Leu Leu Pro Ser Ile Lys Cys Thr Gly 
        675                 680                 685             


Pro Leu Ala Asn Ser Leu Ser Glu Lys Thr Arg Asp Pro Val Glu Glu 
    690                 695                 700                 


Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn 
705                 710                 715                 720 


Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys 
                725                 730                 735     


Asp Asn Gly His Cys Met Leu Asn Gly Thr His Gly Pro Ser Ser Glu 
            740                 745                 750         


Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Asp Val 
        755                 760                 765             


Phe Asp Ser Ala Ser Asp Pro Val Pro Leu Pro Pro Ala Arg Pro Pro 
    770                 775                 780                 


Thr Arg Asp Asn Pro Lys His Gly Ser Ser Leu Asn Arg Thr Pro Ser 
785                 790                 795                 800 


Asp Tyr Asp Leu Leu Ile Pro Pro Leu Gly 
                805                 810 


<210>  9695
<211>  3898
<212>  DNA
<213>  Homosapiens

<400>  9695
ctgggtcctg tgtgtgccac aggggtgggg tgtccagcga gcggtctcct cctcctgcta     60

gtgctgctgc ggcgtcccgc ggcctccccg agtcgggcgg gaggggagag cgggtgtgga    120

tttgtcttga cggtaattgt tgcgtttcca cgtctcggag gcctgcgcgc tgggttgctc    180

cttcttcggg agcgagctgt tctcagcgat cccactccca gccggggctc cccacacaca    240

ctgggctgcg tgcgtgtgga gtgggacccg cgcacacgcg tgtctctgga cagctacggc    300

gccgaaagaa ctaaaattcc agatggcaaa ctcaatgaat ggcagaaacc ctggtggtcg    360

aggaggaaat ccccgaaaag gtcgaatttt gggtattatt gatgctattc aggatgcagt    420

tggaccccct aagcaagctg ccgcagatcg caggaccgtg gagaagactt ggaagctcat    480

ggacaaagtg gtaagactgt gccaaaatcc caaacttcag ttgaaaaata gcccaccata    540

tatacttgat attttgcctg atacatatca gcatttacga cttatattga gtaaatatga    600

tgacaaccag aaacttgccc aactcagtga gaatgagtac tttaaaatct acattgatag    660

ccttatgaaa aagtcaaaac gggcaataag actctttaaa gaaggcaagg agagaatgta    720

tgaagaacag tcacaggaca gacgaaatct cacaaaactg tcccttatct tcagtcacat    780

gctggcagaa atcaaagcaa tctttcccaa tggtcaattc cagggagata actttcgtat    840

cacaaaagca gatgctgctg aattctggag aaagtttttt ggagacaaaa ctatcgtacc    900

atggaaagta ttcagacagt gccttcatga ggtccaccag attagctctg gcctggaagc    960

aatggctcta aaatcaacaa ttgatttaac ttgcaatgat tacatttcag tttttgaatt   1020

tgatattttt accaggctgt ttcagccttg gggctctatt ttgcggaatt ggaatttctt   1080

agctgtgaca catccaggtt acatggcatt tctcacatat gatgaagtta aagcacgact   1140

acagaaatat agcaccaaac ccggaagcta tattttccgg ttaagttgca ctcgattggg   1200

acagtgggcc attggctatg tgactgggga tgggaatatc ttacagacca tacctcataa   1260

caagccctta tttcaagccc tgattgatgg cagcagggaa ggattttatc tttatcctga   1320

tgggaggagt tataatcctg atttaactgg attatgtgaa cctacacctc atgaccatat   1380

aaaagttaca caggaacaat atgaattata ttgtgaaatg ggctccactt ttcagctctg   1440

taagatttgt gcagagaatg acaaagatgt caagattgag ccttgtgggc atttgatgtg   1500

cacctcttgc cttacggcat ggcaggagtc ggatggtcag ggctgccctt tctgtcgttg   1560

tgaaataaaa ggaactgagc ccataatcgt ggaccccttt gatccaagag atgaaggctc   1620

caggtgttgc agcatcattg acccctttgg catgccgatg ctagacttgg acgacgatga   1680

tgatcgtgag gagtccttga tgatgaatcg gttggcaaac gtccgaaagt gcactgacag   1740

gcagaactca ccagtcacat caccaggatc ctctcccctt gcccagagaa gaaagccaca   1800

gcctgaccca ctccagatcc cacatctaag cctgccaccc gtgcctcctc gcctggatct   1860

aattcagaaa ggcatagtta gatctccctg tggcagccca acgggttcac caaagtcttc   1920

tccttgcatg gtgagaaaac aagataaacc actcccagca ccacctcctc ccttaagaga   1980

tcctcctcca ccgccacctg aaagacctcc accaatccca ccagacaata gactgagtag   2040

acacatccat catgtggaaa gcgtgccttc cagagacccg ccaatgcctc ttgaagcatg   2100

gtgccctcgg gatgtgtttg ggactaatca gcttgtggga tgtcgactcc taggggaggg   2160

ctctccaaaa cctggaatca cagcgagttc aaatgtcaat ggaaggcaca gtagagtggg   2220

ctctgaccca gtgcttatgc ggaaacacag acgccatgat ttgcctttag aaggagctaa   2280

ggtcttttcc aatggtcacc ttggaagtga agaatatgat gttcctcccc ggctttctcc   2340

tcctcctcca gttaccaccc tcctccctag cataaagtgt actggtccgt tagcaaattc   2400

tctttcagag aaaacaagag acccagtaga ggaagatgat gatgaataca agattccttc   2460

atcccaccct gtttccctga attcacaacc atctcattgt cataatgtaa aacctcctgt   2520

tcggtcttgt gataatggtc actgtatgct gaatggaaca catggtccat cttcagagaa   2580

gaaatcaaac atccctgact taagcatata tttaaagggt acgtatagaa tataatttcc   2640

tttgtgatgt acatcttaat ggtcagaatt taaaggcaaa atttcatgcc attgtactga   2700

aaatacatta aggttttgtg ttatcctcta ggagatgttt ttgattcagc ctctgatccc   2760

gtgccattac cacctgccag gcctccaact cgggacaatc caaagcatgg ttcttcactc   2820

aacaggacgc cctctgatta tgatcttctc atccctccat taggttgaaa cctttaaaaa   2880

agttttgaac aacccacccc tccttctttt aatttcagaa ttttcagaat tcagagttca   2940

gtataacaca gactcactgg gttgtgaatt tgcctgaaat ttgaatgggt tctccaggtg   3000

ccggtgactc ccaagttcac gagaccatta ctccatgtag atgattaagg tagtagtgta   3060

gtagttgggc atcagtcagg ttttaagcaa gttgttttgt ccatactaaa tgtagtctaa   3120

aaacacatga gagctttgtg ctctagtagt tttgaagtga tgacttgaag tgttgagatt   3180

ttctttaagt ataataattc ttaataaata tgaacttgct tttcttgcag catgagcacc   3240

agttccactt acgctaatta aattatgcaa aattaaatag ttgtatgtag agaactgata   3300

ataaattctg ttttattcta atcattacaa ctgtaacaca ttcaaaaaaa tctcaatttc   3360

cttgtttcaa attataataa tgaagaaaca tcctatgtgt atttttgttt gtatccacag   3420

gtgaaggtat atgtaggtgt gtgtatatgt tgaagttggc tggtgccact gtcactgtta   3480

atttcattaa ttctaattag gaagcatctc accctgtttt tagaagacag aatgtctgca   3540

caccttacat aacgcttcac aataacaagt cactgtaaca taaaataata tatgatgaaa   3600

gtcaatttac aagcttttct gaactggctg ttaggccacc agaaatacga aatgaacctt   3660

tccattttct cacaagtacc actgactagt attttgaatg acacaattgc agtatctttt   3720

gctcctgttc tctctgtagt tcaggacttt attctcacct acatcaatta caaaaggctc   3780

ctaactctgt tacctacagt ctttctctcc cttccacttc ttcctgcaca cttgtttttg   3840

acatattacc cagatcttca tcacctggat aagcattgtt caataaagct ttctgtgg     3898


<210>  9696
<211>  770
<212>  PRT
<213>  Homosapiens

<400>  9696

Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn 
1               5                   10                  15      


Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala 
            20                  25                  30          


Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Thr Val Glu Lys 
        35                  40                  45              


Thr Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys 
    50                  55                  60                  


Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp 
65                  70                  75                  80  


Thr Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln 
                85                  90                  95      


Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp 
            100                 105                 110         


Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly 
        115                 120                 125             


Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Thr 
    130                 135                 140                 


Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile 
145                 150                 155                 160 


Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Thr Lys Ala 
                165                 170                 175     


Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Thr Ile Val 
            180                 185                 190         


Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser 
        195                 200                 205             


Ser Gly Leu Glu Ala Met Ala Leu Lys Ser Thr Ile Asp Leu Thr Cys 
    210                 215                 220                 


Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Thr Arg Leu Phe 
225                 230                 235                 240 


Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Thr 
                245                 250                 255     


His Pro Gly Tyr Met Ala Phe Leu Thr Tyr Asp Glu Val Lys Ala Arg 
            260                 265                 270         


Leu Gln Lys Tyr Ser Thr Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser 
        275                 280                 285             


Cys Thr Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Thr Gly Asp Gly 
    290                 295                 300                 


Asn Ile Leu Gln Thr Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu 
305                 310                 315                 320 


Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser 
                325                 330                 335     


Tyr Asn Pro Asp Leu Thr Gly Leu Cys Glu Pro Thr Pro His Asp His 
            340                 345                 350         


Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser 
        355                 360                 365             


Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys 
    370                 375                 380                 


Ile Glu Pro Cys Gly His Leu Met Cys Thr Ser Cys Leu Thr Ala Trp 
385                 390                 395                 400 


Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys 
                405                 410                 415     


Gly Thr Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly 
            420                 425                 430         


Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp 
        435                 440                 445             


Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu 
    450                 455                 460                 


Ala Asn Val Arg Lys Cys Thr Asp Arg Gln Asn Ser Pro Val Thr Ser 
465                 470                 475                 480 


Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro 
                485                 490                 495     


Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp 
            500                 505                 510         


Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Thr Gly 
        515                 520                 525             


Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu 
    530                 535                 540                 


Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu 
545                 550                 555                 560 


Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His 
                565                 570                 575     


His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala 
            580                 585                 590         


Trp Cys Pro Arg Asp Val Phe Gly Thr Asn Gln Leu Val Gly Cys Arg 
        595                 600                 605             


Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Thr Ala Ser Ser Asn 
    610                 615                 620                 


Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg 
625                 630                 635                 640 


Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser 
                645                 650                 655     


Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser 
            660                 665                 670         


Pro Pro Pro Pro Val Thr Thr Leu Leu Pro Ser Ile Lys Cys Thr Gly 
        675                 680                 685             


Pro Leu Ala Asn Ser Leu Ser Glu Lys Thr Arg Asp Pro Val Glu Glu 
    690                 695                 700                 


Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn 
705                 710                 715                 720 


Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys 
                725                 730                 735     


Asp Asn Gly His Cys Met Leu Asn Gly Thr His Gly Pro Ser Ser Glu 
            740                 745                 750         


Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Thr Tyr 
        755                 760                 765             


Arg Ile 
    770 


<210>  9697
<211>  2361
<212>  DNA
<213>  Homosapiens

<400>  9697
atcaaaagaa gttcaatact aaagataaag agttttcctt attgaaatat atattgttaa     60

gcttttaaac caaatgaaag tatgagtggt catatttata ctgtagtagg ttttcataat    120

agattttccg gattaaaacc atttgttgaa atcatcaaag agatgttaat cctgctttag    180

cattaatgca aagttaaaat aactgacatt aaaaaaatca tttgggaagc tttattgaat    240

atattgagat aaggtttatt gtagtccttc tcttcatgca tactgctgtt acaattccag    300

gaggtttcaa aatccatgtg aatgacccca ttcaaccctc aaactgtcca attcctggcc    360

taattcacct tcactctgct gtagctacca gttgcaggac tagctgcatt ttggccagaa    420

ctgcatcacc ctggaaattt taaacacact ctctctcttc tgattgccct ctttttctgg    480

ttccatctca gctttattcc cactgcattg ttctttatct ttggagctct ctaaatccct    540

ccctagctgt gctagtggtg gatgaggtgt ttaacaaagg aaatgtaaga tcttccttta    600

gttgccagtt cagtgtagtt ttttggaatt agtttgctaa atttctttta aagtgatcag    660

tttagtatcc aaaaagtaaa atggagcaag ttgaaaaatt gtcctgcctg tgtttcagtt    720

taggttgttc ctaggcgcac tgctgacttc tcttatgact ttgggtagat tcagtcttta    780

ttggtatttg aacttttaat gtctgttgtg tactctcctt agacacattt aaaactttaa    840

agcatttggg cagggggaat gggtaaggat ccagttttat ttaagactgt caggacccat    900

ctcaatagta gtatctattc ccatgagaga aaaatgaaag gcaaggctta catcagccta    960

gtctcctcac ttaggaatca caacattcct aaggtcagaa acagtgtgaa gtaagtctct   1020

gaacccattt tggagggcag tacatcagaa atacagtgga aattgctctt tagctggatg   1080

tgagtttcat tttaagcacc actgtttata ttctttatgt cttgcctttc tttttatatt   1140

gagtttgttt caccttgtaa aattaagaag agcatgttct agcttttaaa tgtgagaatt   1200

gaattattaa tagtttttgg gtaaaagtat cacctcccat ttcttctacc aaaagcagca   1260

catcctcaca gacttttcac ctcactgaaa atggtcattt aaagttttta ctaattcagc   1320

atttaaagct ttttatttcc tccttgattt ataacacagc tgtttcttga atagaaaaaa   1380

ctcaaggact acatgcaatc taattagatt acattctttg tgtgagtctc ctgcatttag   1440

tggaggccac taatcaaatc ttgatatatt ttctatttct tttatttatt tattcattta   1500

attcatcaag tcaagatggc tataattaga gcagattact cctaccacat tgtattatga   1560

tgatctcttc atgttttttt gtttcatact atatgatatt cattaagggt agcattgtgc   1620

catcctccat caagcattat atgcttcctt tgtgcttatg atgttgaccg tagcaacctt   1680

aaactgttaa gacttgttta taaacggtga agctccatca ttccaacaga gtcagcatgc   1740

taattcactc tagttcaaat ccacattcta gttgaatccc tgcaatgtaa cttgacattt   1800

ggagaaattg attcatacca ttttaaagaa atatgatata ggtgacagaa tccaggatga   1860

agaggtacct tgttgcttag atgatgacgt tgtggattca tttcacatct ctctctcttt   1920

ttaatgtagc tcttctccct ccttggtttt tattcctccc tccttctttc ttcttcaagc   1980

ctcctctaat gttaacatct ttggcagttt ggccagtgtt gacaactact ttttgattat   2040

ttggtatttt aaaatatttg gtattttaaa atgcttttat tggccaggcg tggtggctca   2100

caccttataa tcccagtact ttgggaggcc gaggcgggca gatcatgagg tcgagattga   2160

gaccatcctg gctaacacgg tgaaaccctg tctctactaa aactacaaaa aattagctgg   2220

gcatggtggc gggcgcctgt agtcccagct actcaggagg ctgaggcagg agaatggcat   2280

gaacctggga ggtggagctg gcagtgagcc gagatcgcgc caccgcactc tagcctgggt   2340

gacagagcga gactccatct c                                             2361


<210>  9698
<211>  55
<212>  PRT
<213>  Homosapiens

<400>  9698

Met His Thr Ala Val Thr Ile Pro Gly Gly Phe Lys Ile His Val Asn 
1               5                   10                  15      


Asp Pro Ile Gln Pro Ser Asn Cys Pro Ile Pro Gly Leu Ile His Leu 
            20                  25                  30          


His Ser Ala Val Ala Thr Ser Cys Arg Thr Ser Cys Ile Leu Ala Arg 
        35                  40                  45              


Thr Ala Ser Pro Trp Lys Phe 
    50                  55  


<210>  9699
<211>  388
<212>  DNA
<213>  Homosapiens

<400>  9699
atcagtaaga gaaattatct gaagtggatt tgaagactct tcctttgatt ctagtgaaga     60

gatcctttaa gaccctgaga aaacatgtgg caattctctg tgaatttgga aaggaagcat    120

tcacctatga aagaaaatgc ttccatcagg tacttcaagg ttgaagaggc agaggacgag    180

ttatccacaa ggaatttgga agagaagctt gtttcaaagt tggatgagcc atgagaacaa    240

ctaccaaata aatcattgtg tggaaaagaa ttgatttggg aatcaattgt ctgggaaaga    300

aaatcacaaa gaagtgattg tgaagacatt catttgttct tcagatatgt aactgtttaa    360

tctgaagtaa actttgggat ggaaaact                                       388


<210>  9700
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  9700

Met Leu Pro Ser Gly Thr Ser Arg Leu Lys Arg Gln Arg Thr Ser Tyr 
1               5                   10                  15      


Pro Gln Gly Ile Trp Lys Arg Ser Leu Phe Gln Ser Trp Met Ser His 
            20                  25                  30          


Glu Asn Asn Tyr Gln Ile Asn His Cys Val Glu Lys Asn 
        35                  40                  45  


<210>  9701
<211>  3090
<212>  DNA
<213>  Homosapiens

<400>  9701
atgggaactg gggggagcaa agagtgggga actgggcagg cagacacccc cacagagcac     60

tcatggcccc cacagaaata cacccacact catcacagca aaccaaaaca atcacacgcc    120

ggtacacaaa cacacacacc cccgcaccaa tccaggcaga cacaaagctc acggcgacag    180

gcagatctga ttcacacaga cacaggcaca ggtgcttcct gatgccaccc tctcttggtc    240

acgtgccagc acttggaggg aggaaagtgc ctcaccaggc tgagatgccc aagggacccc    300

ccagggaggg aaagcaggac acactgggac agttgcttcc agccctgtcc acacccttgt    360

gcccatcagg tatgccgctc acccccaccc cacctggacc ttggtgtcac ctaggattgc    420

agaggccgcc ttcagcccag agcctggggc cttgcccact gcctcacctc ccaggatagg    480

gcatgctgtt cctttctcct tccctttctt tgctcttgtg tgcctgcctt tagcaaacgc    540

ccactgggtg tgtgggtaca ctgcggcctt taaagagaag agaaacacat gaggcttaca    600

gcaggaggcc ctgcctaggt tccaagggac atggagcagg gtggctgtgt agagctgggg    660

agcatcccaa gcctgtgcca aggttccaag gacaaaaagg gcaaggaggc ccagtgcggg    720

gtggtggggg agcagctagc cagggccaac agtgagcctc gcgcctgggc aggtgtagcc    780

tttaaacgcg gtgggggaac catggacagc atctaagcag ggacgtgccg tgagtcctgg    840

gggtgcaggg gtgtctagag gggaagctgg gaagcagggg tcacagcttt ccgactggtg    900

gctgagtgtg gggaagacag gaggggcagg tgtgagatgt acagcagaca cagctgtgtg    960

ctggggcatg gtgggctgtg gtgagagaga ggagcaggtc ttctccccgc gtgttcagag   1020

cagatccaaa ctcttctccc attccttcct ccaccgtgca tcctcagcac ccctcagcac   1080

tggcctgtgt gggcagcgtg agcacagaga gcaggagctt gccctcagag gcttcagggg   1140

gtcgcttgta cccagtggta tggtcagcat catgtttgac caaagggagg aaggtggctg   1200

tgaccagagc gagggggggt cctgatgcag ctggggagtc aggctcgagt gcatgctgtg   1260

catgttctct gcctctcttc ctggggggca ggcgagtctc cagagcctgg aggacaagtt   1320

agccttgcga aggatagcag aggacccagc ccaggggtcc ccaaaatgga gcaccaaccc   1380

tccatgcagg ccaagccact ggtgaatatg ctgcaaaaaa tatgctggaa cttctatgaa   1440

taccacaggg tgtgagaaga aaacattaga acttctattt tgtacctgtg ttactccaca   1500

acaagaaagc aatcagcttg atcaatgcct actgtaaaga cggcaccgcc ctccggaggt   1560

cctttctcag ccctggtgtt cggacagcca catcccctcg cagcaggggg aggcctgaag   1620

catagagggg cccatgcagg tctattctgt ttcagcgaat tgcctgggaa ataatccagg   1680

atccatttcg tgtggtcatc ttgtctccct ggtcccctcc agcctttcct catcttttgt   1740

gacctggtca ctctggaagg gcgctggcca gttagtccac aggatgggcc tcccctgggg   1800

cttttctgat gcttccttat gatggcactg gcatcctgag ggggaggacc acagagagga   1860

ggtgctcctc atcacaccac atgggggtcc atgcaccagt gccactgctt tccagggctc   1920

ttcaccttca tcactggtgg aggtggcgtc tgccaagaag cagaaagttg aggcttagaa   1980

ggtgcacggc cctacctctt ccgaggtgcc cctgcgggct gtctacagac caggcagcac   2040

atgcctgata gcagctgcat aaggaaaagc aggagccagc tcgtgcacag tggcctcaag   2100

tgtgcactgg gcatgttctc tgcctcacca tccctgtgtg acagatgaag catgacagcc   2160

ctcaacagaa gccaaggcca agtcctcgaa cttcctagtc tgcacaatgt ctgtctttca   2220

gacacttctg atgaaactga aaatgccacc agggagaagc agctgaactt caaggaccac   2280

agagggccaa gtgcaggagt aagaggctgg cgtgctgaca gtggccaagg gcattggagg   2340

gaaggacctg tcatcactgg gccaaggaag gaactccaga ctgcctactt ccagagggcc   2400

tgctgaggaa ttttagcttg aacttgcctg ccttgactag ggctttctga gcagcagatg   2460

attctgcaat ggtgttagtc caggcctggt tctgcatgac attgaccata ctgtgcaccc   2520

tggggtcatt atgtcttggg cttcaagggg ctccatgggc tccagggggc tccatgtgac   2580

actgcacaga gctctctcta ggtcacctgg atgtgtctct tcctaggaac cccaaagagc   2640

tctctcaaca aacacaccca cgagttccag gagtgaggct gcagggaaca gcctcactct   2700

cagaggggat acagaattgt tccactggac aagggctggg atcgtcatag gatgccgttg   2760

gcctgtggtt tccaacagag gtgcagttca ttgaactgtg gtctacagtc cattctctaa   2820

cttggggacc cttgaagaag tgtggaatca tgacaacaac cctgttggga gacactatta   2880

ttcccatcac atggatgagc acacggaggc aaaaggaagt tatatgattg tctgagatca   2940

cccagtgaag actgtgtggc tgggagttgt ccccagtgtt atctgcacgc tgcttccttt   3000

tgatgcctgg cccttcttta tcaaaagaag cattggcaga atctgggtgt ttatgggtca   3060

gctcaaaata aattacttta tatgtcattc                                    3090


<210>  9702
<211>  84
<212>  PRT
<213>  Homosapiens

<400>  9702

Met Thr Ala Leu Asn Arg Ser Gln Gly Gln Val Leu Glu Leu Pro Ser 
1               5                   10                  15      


Leu His Asn Val Cys Leu Ser Asp Thr Ser Asp Glu Thr Glu Asn Ala 
            20                  25                  30          


Thr Arg Glu Lys Gln Leu Asn Phe Lys Asp His Arg Gly Pro Ser Ala 
        35                  40                  45              


Gly Val Arg Gly Trp Arg Ala Asp Ser Gly Gln Gly His Trp Arg Glu 
    50                  55                  60                  


Gly Pro Val Ile Thr Gly Pro Arg Lys Glu Leu Gln Thr Ala Tyr Phe 
65                  70                  75                  80  


Gln Arg Ala Cys 
                


<210>  9703
<211>  692
<212>  DNA
<213>  Homosapiens

<400>  9703
cccggtctag tagggagggc ttcctggagt agggacagcc acattcatcc cggctgtgga     60

ctgaactgtg tccccttcag atgtcatatg ttgaagccct tgcctccact gtgactgcat    120

ttggagactg ggcctatcag gagataagag atcacatgga gacacagcaa gaaggcagct    180

gtctgcagcc aggaagagag ccctcagcag aacctgcgcc tgccagcacc atggtcttgg    240

actcccagtc tccagaacta tgagaaactg taagtcagag ttaagactgg agcccaggcc    300

atctccctcc accacccaca cctgacatcc gcacactgcg cttcctgcat ggtggacagt    360

gcctgcctgc tcacaactgg gaccactgcc tcctctgctt ctctgtagcc ctggccctag    420

ctcgtggaag gagcaacagg gccatatttg agtttcagag cactgctcag gggggcagaa    480

ggcagggtca gattcttctg gaagaggtcg gaggtttccc agccagaaca aaactgggat    540

gagaagctgg ggttcctccc acccctctcc aggacctgtg aatgtccctc ccctgtggag    600

ctggaaagcc agcccgaagg cacctgcccc gtgggaggac acacccctga gcctggatgc    660

ctcatctcct gcagctttgg aattctagcc cc                                  692


<210>  9704
<211>  60
<212>  PRT
<213>  Homosapiens

<400>  9704

Met Ser Tyr Val Glu Ala Leu Ala Ser Thr Val Thr Ala Phe Gly Asp 
1               5                   10                  15      


Trp Ala Tyr Gln Glu Ile Arg Asp His Met Glu Thr Gln Gln Glu Gly 
            20                  25                  30          


Ser Cys Leu Gln Pro Gly Arg Glu Pro Ser Ala Glu Pro Ala Pro Ala 
        35                  40                  45              


Ser Thr Met Val Leu Asp Ser Gln Ser Pro Glu Leu 
    50                  55                  60  


<210>  9705
<211>  1227
<212>  DNA
<213>  Homosapiens

<400>  9705
aatgcagagg tgggggacag agtgggtggg gaggggagcc gccatacagt ggccaggacc     60

agctttgccc aagtggtggc aaccgcatga ccacaggaac gatggcgcca agccactggt    120

gaatatgctg caaaaaatat gctggaactt ctatgaatac cacagggtgt gagaagaaaa    180

cattagaact tctattttgt acctgtgtta ctccacaaca agaaagcaat cagcttgatc    240

aatgcctact gtaaagacgg caccgccctc cggaggtcct ttctcagccc tggtgttcgg    300

acagccacat cccctcgcag cagggggagg cctgaagcat agaggggccc atgcaggtct    360

attctgtttc agcgaattgc ctgggaaata atccaggatc catttcgtgt ggtcatcttg    420

tctccctggt cccctccagc ctttcctcat cttttgtgac ctggtcactc tggaagggcg    480

ctggccagtt agtccacagg atgggcctcc cctggggctt ttctgatgct tccttatgat    540

ggcactggca tcctgagggg gaggaccaca gagaggaggt gctcctcatc acaccacatg    600

ggggtccatg caccagtgcc actgctttcc agggctcttc accttcatca ctggtggagg    660

tggcgtctgc caagaagcag aaagttgagg cttagaaggt gcacggccct acctcttccg    720

aggtgcccct gcgggctgtc tacagaccag gcagcacatg cctgatagca gctgcataag    780

gaaaagcagg agccagctcg tgcacagtgg cctcaagtaa gccaaggcca agtcctcgaa    840

cttcctagtc tgcacaatgt ctgtctttca gacacttctg atgaaactga aaatgccacc    900

agggagaagc agctgaaata acacttgtgc tgaggtcgct gagccactgt ggaagacatc    960

caagctccat aaagacaggt caagtgcaca tgctccagtc aacagcccag ctgagccctc   1020

agcatacagc caacaccaac tgcaagctga gggtgaaaca acttggatgt ccatttggat   1080

gtcaagctgg acttcagatg cctgtggttg cagctctgtc tgcaactaca tggaagacgc   1140

catgtgaacc acctagtaga gcccttccta gaattgttgg ccctcagact ctacatgcat   1200

atcaaaatga atgttgtttg aagccat                                       1227


<210>  9706
<211>  79
<212>  PRT
<213>  Homosapiens

<400>  9706

Met Leu Pro Tyr Asp Gly Thr Gly Ile Leu Arg Gly Arg Thr Thr Glu 
1               5                   10                  15      


Arg Arg Cys Ser Ser Ser His His Met Gly Val His Ala Pro Val Pro 
            20                  25                  30          


Leu Leu Ser Arg Ala Leu His Leu His His Trp Trp Arg Trp Arg Leu 
        35                  40                  45              


Pro Arg Ser Arg Lys Leu Arg Leu Arg Arg Cys Thr Ala Leu Pro Leu 
    50                  55                  60                  


Pro Arg Cys Pro Cys Gly Leu Ser Thr Asp Gln Ala Ala His Ala 
65                  70                  75                  


<210>  9707
<211>  226
<212>  DNA
<213>  Homosapiens

<400>  9707
gtctgtcttt cagacacttc tgatgaaact gaaaatgcca ccagggagaa gcagctgaag     60

aggatttttt tttgtttcac cccagcaatg tgagagatag aatggatgcc ctaaagaaga    120

ggatgcagca gaaattagga agagataaag aagagcaaca ttccttaaga aatgccctat    180

ggttgggaat ggccatttca tgttagaaac aaaggtgata atattc                   226


<210>  9708
<211>  34
<212>  PRT
<213>  Homosapiens

<400>  9708

Met Asp Ala Leu Lys Lys Arg Met Gln Gln Lys Leu Gly Arg Asp Lys 
1               5                   10                  15      


Glu Glu Gln His Ser Leu Arg Asn Ala Leu Trp Leu Gly Met Ala Ile 
            20                  25                  30          


Ser Cys 
        


<210>  9709
<211>  420
<212>  DNA
<213>  Homosapiens

<400>  9709
gtgaccgggg tcctgcccaa gggtcctgct tccctaggca tcccagaagt tcagcctgca     60

tctcgaccag agcctgagag tagacacctg ccggtttatc tgtcccttca tgtagcaggt    120

gacagaggtg ccaggggcat ggcaggggta ctctgacaca gcactgcccc acggagccca    180

tgtcccaggg cagaagaccc acgatgcaca gccagccagg tggcctcatc cgatcagtca    240

aaggcctcaa tagaaccaag actgacctct gccaaagaga gaattctttc agcagacggc    300

cttcggactt gagctatgac ggcaactctt ccccgggccc acctgacgga ctgggtttct    360

cagcctccac agtcgtgtga gccaattccg taagataaat ctctctctct tctctctcaa    420


<210>  9710
<211>  66
<212>  PRT
<213>  Homosapiens

<400>  9710

Met Ser Gln Gly Arg Arg Pro Thr Met His Ser Gln Pro Gly Gly Leu 
1               5                   10                  15      


Ile Arg Ser Val Lys Gly Leu Asn Arg Thr Lys Thr Asp Leu Cys Gln 
            20                  25                  30          


Arg Glu Asn Ser Phe Ser Arg Arg Pro Ser Asp Leu Ser Tyr Asp Gly 
        35                  40                  45              


Asn Ser Ser Pro Gly Pro Pro Asp Gly Leu Gly Phe Ser Ala Ser Thr 
    50                  55                  60                  


Val Val 
65      


<210>  9711
<211>  1870
<212>  DNA
<213>  Homosapiens

<400>  9711
gccttgcaca tggagatgct tagctgaggg ggtggctttg ttagactatt tgcaggtcgt     60

gagatagagc ctgagatggg ggactgggcc cctgcctggg ggattgggtc gtgacctgtg    120

tggagcccca cactgagctg cagtgggtgg ggagggtggt ttacaggggt gctctgtgca    180

gcccctctga ttttcccctg ggagtcccag gtccagggga aggaggacag tggcccaggc    240

cacacagctc actgggcggc tctcactccc ccagggctgg ctgctggcgg gatggacacc    300

ctggaggagg tgacttgggc caatgggagc acagcgctac ccccacccct ggcaccaaac    360

atcagtgtgc ctcatcgctg cctgctgctg ctctacgaag acattggcac ctccagggtc    420

cggtactggg acctcttgct gctcatcccc aatgtgctct tcctcatctt cctgctctgg    480

aagcttccat ctgctcgggc gaagatccgc atcacctcca gccccatttt tatcaccttc    540

tacatcctgg tgtttgtggt ggcgctggtg ggcattgccc gggccgtggt atccatgacg    600

gtgagcacct cgaacgctgc aactgttgct gataagatcc tgtgggagat cacccgcttc    660

ttcctgctgg ccatcgagct gagtgtgatc atcctgggcc tggcctttgg ccacctggag    720

agtaagtcca gcatcaagcg ggtgctggcc atcaccacag tgctgtccct ggcctactct    780

gtcacccagg ggaccctgga gatcctgtac cctgatgccc atctctcagc tgaggacttt    840

aatatctatg gccatggggg ccgccagttc tggctggtca gctcctgctt cttcttcctg    900

gtctactctc tggtggtcat ccttcccaag accccgctga aggagcgcat ctccctgcct    960

tctcggagga gcttctacgt gtatgcgggc atcctggcac tgctcaacct actgcagggg   1020

ctggggagtg tgctgctgtg cttcgacatc atcgaggggc tctgctgtgt agatgccaca   1080

accttcctgt acttcagctt cttcgctccg ctcatctacg tggctttcct ccggggcttc   1140

ttcggctcgg agcccaagat cctcttctcc tacaaatgcc aagtggacga gacagaggag   1200

ccagatgtac acctacccca gccctacgct gtggcccggc gggagggcct ggaggctgca   1260

ggggctgctg gggcctcagc tgccagctac tcgagcacgc agttcgactc tgccggcggg   1320

gtggcctacc tggatgacat cgcttccatg ccctgccaca ctggcagcat caacagcaca   1380

gacagcgagc gctggaaggc catcaatgcc tgagggcagc tgccagggcc tgtggaggac   1440

aggccagaga ggaggccagc aggcccagag tccccagggg aggaggacca ggtcaaggga   1500

cgttctgtgg gcagtagccc tgtgtggccc tgttcccacc atgagtctgg aggccccacc   1560

tccctggggc tcccaatccc ctttgccatc tctgctctca ctggggaccc tcctcccctt   1620

cccacctgct ctcatactgc tcagtgacat ggcccaggct ttccttccag ggccatgctt   1680

ggcaaggttg gctgagggca ccctccttct ctgcaccctt ggcacgaggg cagggctggc   1740

tctcccaatg cctccatccc atccccatgg tgctttggcc tcctcaaagc atccaccatg   1800

gtggatggac tgaagtgtgt atattttctt gatctatttt ttaataaaaa ggaaaaggag   1860

cagaaggtgc                                                          1870


<210>  9712
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  9712

Met Asp Thr Leu Glu Glu Val Thr Trp Ala Asn Gly Ser Thr Ala Leu 
1               5                   10                  15      


Pro Pro Pro Leu Ala Pro Asn Ile Ser Val Pro His Arg Cys Leu Leu 
            20                  25                  30          


Leu Leu Tyr Glu Asp Ile Gly Thr Ser Arg Val Arg Tyr Trp Asp Leu 
        35                  40                  45              


Leu Leu Leu Ile Pro Asn Val Leu Phe Leu Ile Phe Leu Leu Trp Lys 
    50                  55                  60                  


Leu Pro Ser Ala Arg Ala Lys Ile Arg Ile Thr Ser Ser Pro Ile Phe 
65                  70                  75                  80  


Ile Thr Phe Tyr Ile Leu Val Phe Val Val Ala Leu Val Gly Ile Ala 
                85                  90                  95      


Arg Ala Val Val Ser Met Thr Val Ser Thr Ser Asn Ala Ala Thr Val 
            100                 105                 110         


Ala Asp Lys Ile Leu Trp Glu Ile Thr Arg Phe Phe Leu Leu Ala Ile 
        115                 120                 125             


Glu Leu Ser Val Ile Ile Leu Gly Leu Ala Phe Gly His Leu Glu Ser 
    130                 135                 140                 


Lys Ser Ser Ile Lys Arg Val Leu Ala Ile Thr Thr Val Leu Ser Leu 
145                 150                 155                 160 


Ala Tyr Ser Val Thr Gln Gly Thr Leu Glu Ile Leu Tyr Pro Asp Ala 
                165                 170                 175     


His Leu Ser Ala Glu Asp Phe Asn Ile Tyr Gly His Gly Gly Arg Gln 
            180                 185                 190         


Phe Trp Leu Val Ser Ser Cys Phe Phe Phe Leu Val Tyr Ser Leu Val 
        195                 200                 205             


Val Ile Leu Pro Lys Thr Pro Leu Lys Glu Arg Ile Ser Leu Pro Ser 
    210                 215                 220                 


Arg Arg Ser Phe Tyr Val Tyr Ala Gly Ile Leu Ala Leu Leu Asn Leu 
225                 230                 235                 240 


Leu Gln Gly Leu Gly Ser Val Leu Leu Cys Phe Asp Ile Ile Glu Gly 
                245                 250                 255     


Leu Cys Cys Val Asp Ala Thr Thr Phe Leu Tyr Phe Ser Phe Phe Ala 
            260                 265                 270         


Pro Leu Ile Tyr Val Ala Phe Leu Arg Gly Phe Phe Gly Ser Glu Pro 
        275                 280                 285             


Lys Ile Leu Phe Ser Tyr Lys Cys Gln Val Asp Glu Thr Glu Glu Pro 
    290                 295                 300                 


Asp Val His Leu Pro Gln Pro Tyr Ala Val Ala Arg Arg Glu Gly Leu 
305                 310                 315                 320 


Glu Ala Ala Gly Ala Ala Gly Ala Ser Ala Ala Ser Tyr Ser Ser Thr 
                325                 330                 335     


Gln Phe Asp Ser Ala Gly Gly Val Ala Tyr Leu Asp Asp Ile Ala Ser 
            340                 345                 350         


Met Pro Cys His Thr Gly Ser Ile Asn Ser Thr Asp Ser Glu Arg Trp 
        355                 360                 365             


Lys Ala Ile Asn Ala 
    370             


<210>  9713
<211>  1956
<212>  DNA
<213>  Homosapiens

<400>  9713
gagtgataac agggactctg ggactctggg acttgtggga ctgtggccgt tttcgcaatt     60

tgggctggac gaaaaagacg gtcttgcttt cccggtcgcc gctgtcggga agggctgcag    120

ggtgtccgcg agacccgcgg cccggcgagc tgaccccgcc tcgcctttcc tgcctagccc    180

tcattccacg gagccggtcg cgcccggtcc ttgcgcgacg cttcccggcc caggccgcct    240

ggtctggcgc tggaggccgg agtcccgcgg cctgtgctgg atccgcgcac acccagtggc    300

ggcggatggg cggccggggc ggccggggcg gccggtcctg agcgcggccc gggctgtcag    360

ggctggctgc tggcgggatg gacaccctgg aggaggtgac ttgggccaat gggagcacag    420

cgctaccccc acccctggca ccaaacatca gtgtgcctca tcgctgcctg ctgctgctct    480

acgaagacat tggcacctcc agggtccggt actgggacct cttgctgctc atccccaatg    540

tgctcttcct catcttcctg ctctggaagc ttccatctgc tcgggcgaag atccgcatca    600

cctccagccc catttttatc accttctaca tcctggtgtt tgtggtggcg ctggtgggca    660

ttgcccgggc cgtggtatcc atgacggtga gcacctcgaa cgctgcaact gttgctgata    720

agatcctgtg ggagatcacc cgcttcttcc tgctggccat cgagctgagt gtgatcatcc    780

tgggcctggc ctttggccac ctggagagta agtccagcat caagcgggtg ctggccatca    840

ccacagtgct gtccctggcc tactctgtca cccaggggac cctggagatc ctgtaccctg    900

atgcccatct ctcagctgag gactttaata tctatggcca tgggggccgc cagttctggc    960

tggtcagctc ctgcttcttc ttcctggtct actctctggt ggtcatcctt cccaagaccc   1020

cgctgaagga gcgcatctcc ctgccttctc ggaggagctt ctacgtgtat gcgggcatcc   1080

tggcactgct caacctactg caggggctgg ggagtgtgct gctgtgcttc gacatcatcg   1140

aggggctctg ctgtgtagat gccacaacct tcctgtactt cagcttcttc gctccgctca   1200

tctacgtggc tttcctccgg ggcttcttcg gctcggagcc caagatcctc ttctcctaca   1260

aatgccaagt ggacgagaca gaggagccag atgtacacct accccagccc tacgctgtgg   1320

cccggcggga gggcctggag gctgcagggg ctgctggggc ctcagctgcc agctactcga   1380

gcacgcagtt cgactctgcc ggcggggtgg cctacctgga tgacatcgct tccatgccct   1440

gccacactgg cagcatcaac agcacagaca gcgagcgctg gaaggccatc aatgcctgag   1500

ggcagctgcc agggcctgtg gaggacaggc cagagaggag gccagcaggc ccagagtccc   1560

caggggagga ggaccaggtc aagggacgtt ctgtgggcag tagccctgtg tggccctgtt   1620

cccaccatga gtctggaggc cccacctccc tggggctccc aatccccttt gccatctctg   1680

ctctcactgg ggaccctcct ccccttccca cctgctctca tactgctcag tgacatggcc   1740

caggctttcc ttccagggcc atgcttggca aggttggctg agggcaccct ccttctctgc   1800

acccttggca cgagggcagg gctggctctc ccaatgcctc catcccatcc ccatggtgct   1860

ttggcctcct caaagcatcc accatggtgg atggactgaa gtgtgtatat tttcttgatc   1920

tattttttaa taaaaaggaa aaggagcaga aggtgc                             1956


<210>  9714
<211>  373
<212>  PRT
<213>  Homosapiens

<400>  9714

Met Asp Thr Leu Glu Glu Val Thr Trp Ala Asn Gly Ser Thr Ala Leu 
1               5                   10                  15      


Pro Pro Pro Leu Ala Pro Asn Ile Ser Val Pro His Arg Cys Leu Leu 
            20                  25                  30          


Leu Leu Tyr Glu Asp Ile Gly Thr Ser Arg Val Arg Tyr Trp Asp Leu 
        35                  40                  45              


Leu Leu Leu Ile Pro Asn Val Leu Phe Leu Ile Phe Leu Leu Trp Lys 
    50                  55                  60                  


Leu Pro Ser Ala Arg Ala Lys Ile Arg Ile Thr Ser Ser Pro Ile Phe 
65                  70                  75                  80  


Ile Thr Phe Tyr Ile Leu Val Phe Val Val Ala Leu Val Gly Ile Ala 
                85                  90                  95      


Arg Ala Val Val Ser Met Thr Val Ser Thr Ser Asn Ala Ala Thr Val 
            100                 105                 110         


Ala Asp Lys Ile Leu Trp Glu Ile Thr Arg Phe Phe Leu Leu Ala Ile 
        115                 120                 125             


Glu Leu Ser Val Ile Ile Leu Gly Leu Ala Phe Gly His Leu Glu Ser 
    130                 135                 140                 


Lys Ser Ser Ile Lys Arg Val Leu Ala Ile Thr Thr Val Leu Ser Leu 
145                 150                 155                 160 


Ala Tyr Ser Val Thr Gln Gly Thr Leu Glu Ile Leu Tyr Pro Asp Ala 
                165                 170                 175     


His Leu Ser Ala Glu Asp Phe Asn Ile Tyr Gly His Gly Gly Arg Gln 
            180                 185                 190         


Phe Trp Leu Val Ser Ser Cys Phe Phe Phe Leu Val Tyr Ser Leu Val 
        195                 200                 205             


Val Ile Leu Pro Lys Thr Pro Leu Lys Glu Arg Ile Ser Leu Pro Ser 
    210                 215                 220                 


Arg Arg Ser Phe Tyr Val Tyr Ala Gly Ile Leu Ala Leu Leu Asn Leu 
225                 230                 235                 240 


Leu Gln Gly Leu Gly Ser Val Leu Leu Cys Phe Asp Ile Ile Glu Gly 
                245                 250                 255     


Leu Cys Cys Val Asp Ala Thr Thr Phe Leu Tyr Phe Ser Phe Phe Ala 
            260                 265                 270         


Pro Leu Ile Tyr Val Ala Phe Leu Arg Gly Phe Phe Gly Ser Glu Pro 
        275                 280                 285             


Lys Ile Leu Phe Ser Tyr Lys Cys Gln Val Asp Glu Thr Glu Glu Pro 
    290                 295                 300                 


Asp Val His Leu Pro Gln Pro Tyr Ala Val Ala Arg Arg Glu Gly Leu 
305                 310                 315                 320 


Glu Ala Ala Gly Ala Ala Gly Ala Ser Ala Ala Ser Tyr Ser Ser Thr 
                325                 330                 335     


Gln Phe Asp Ser Ala Gly Gly Val Ala Tyr Leu Asp Asp Ile Ala Ser 
            340                 345                 350         


Met Pro Cys His Thr Gly Ser Ile Asn Ser Thr Asp Ser Glu Arg Trp 
        355                 360                 365             


Lys Ala Ile Asn Ala 
    370             


<210>  9715
<211>  1792
<212>  DNA
<213>  Homosapiens

<400>  9715
gagtgataac agggactctg ggactctggg acttgtggga ctgtggccgt tttcgcaatt     60

tgggctggac gaaaaagacg gtcttgcttt cccggtcgcc gctgtcggga agggctgcag    120

ggtgtccgcg agacccgcgg cccggcgagc tgaccccgcc tcgcctttcc tgcctagccc    180

tcattccacg gagccggtcg cgcccggtcc ttgcgcgacg cttcccggcc caggccgcct    240

ggtctggcgc tggaggccgg agtcccgcgg cctgtgctgg atccgcgcac acccagtggc    300

ggcggatggg cggccggggc ggccggggcg gccggtcctg agcgcggccc gggctgtcag    360

ggctggctgc tggcgggatg gacaccctgg aggaggtgac ttgggccaat gggagcacag    420

cgctaccccc acccctggca ccaaacatca gtgtgcctca tcgctgcctg ctgctgctct    480

acgaagacat tggcacctcc agggtccggt actgggacct cttgctgctc atccccaatg    540

tgctcttcct catcttcctg ctctggaagc ttccatctgc tcgggcgaag atccgcatca    600

cctccagccc catttttatc accttctaca tcctggtgtt tgtggtggcg ctggtgggca    660

ttgcccgggc cgtggtatcc atgacggtga gcacctcgaa cgctgcaact gttgctgata    720

agatcctgtg ggagatcacc cgcttcttcc tgctggccat cgagctgagt gtgatcatcc    780

tgggcctggc ctttggccac ctggagagta agtccagcat caagcgggtg ctggccatca    840

ccacagtgct gtccctggcc tactctgtca cccaggggac cctggagatc ctgtaccctg    900

atgcccatct ctcagctgag gactttaata tctatggcca tgggggccgc cagttctggc    960

tggtcagctc ctgcttcttc ttcctgctgt gtagatgcca caaccttcct gtacttcagc   1020

ttcttcgctc cgctcatcta cgtggctttc ctccggggct tcttcggctc ggagcccaag   1080

atcctcttct cctacaaatg ccaagtggac gagacagagg agccagatgt acacctaccc   1140

cagccctacg ctgtggcccg gcgggagggc ctggaggctg caggggctgc tggggcctca   1200

gctgccagct actcgagcac gcagttcgac tctgccggcg gggtggccta cctggatgac   1260

atcgcttcca tgccctgcca cactggcagc atcaacagca cagacagcga gcgctggaag   1320

gccatcaatg cctgagggca gctgccaggg cctgtggagg acaggccaga gaggaggcca   1380

gcaggcccag agtccccagg ggaggaggac caggtcaagg gacgttctgt gggcagtagc   1440

cctgtgtggc cctgttccca ccatgagtct ggaggcccca cctccctggg gctcccaatc   1500

ccctttgcca tctctgctct cactggggac cctcctcccc ttcccacctg ctctcatact   1560

gctcagtgac atggcccagg ctttccttcc agggccatgc ttggcaaggt tggctgaggg   1620

caccctcctt ctctgcaccc ttggcacgag ggcagggctg gctctcccaa tgcctccatc   1680

ccatccccat ggtgctttgg cctcctcaaa gcatccacca tggtggatgg actgaagtgt   1740

gtatattttc ttgatctatt ttttaataaa aaggaaaagg agcagaaggt gc           1792


<210>  9716
<211>  293
<212>  PRT
<213>  Homosapiens

<400>  9716

Met Asp Thr Leu Glu Glu Val Thr Trp Ala Asn Gly Ser Thr Ala Leu 
1               5                   10                  15      


Pro Pro Pro Leu Ala Pro Asn Ile Ser Val Pro His Arg Cys Leu Leu 
            20                  25                  30          


Leu Leu Tyr Glu Asp Ile Gly Thr Ser Arg Val Arg Tyr Trp Asp Leu 
        35                  40                  45              


Leu Leu Leu Ile Pro Asn Val Leu Phe Leu Ile Phe Leu Leu Trp Lys 
    50                  55                  60                  


Leu Pro Ser Ala Arg Ala Lys Ile Arg Ile Thr Ser Ser Pro Ile Phe 
65                  70                  75                  80  


Ile Thr Phe Tyr Ile Leu Val Phe Val Val Ala Leu Val Gly Ile Ala 
                85                  90                  95      


Arg Ala Val Val Ser Met Thr Val Ser Thr Ser Asn Ala Ala Thr Val 
            100                 105                 110         


Ala Asp Lys Ile Leu Trp Glu Ile Thr Arg Phe Phe Leu Leu Ala Ile 
        115                 120                 125             


Glu Leu Ser Val Ile Ile Leu Gly Leu Ala Phe Gly His Leu Glu Ser 
    130                 135                 140                 


Lys Ser Ser Ile Lys Arg Val Leu Ala Ile Thr Thr Val Leu Ser Leu 
145                 150                 155                 160 


Ala Tyr Ser Val Thr Gln Gly Thr Leu Glu Ile Leu Tyr Pro Asp Ala 
                165                 170                 175     


His Leu Ser Ala Glu Asp Phe Asn Ile Tyr Gly His Gly Gly Arg Gln 
            180                 185                 190         


Phe Trp Leu Val Ser Ser Cys Phe Phe Phe Leu Leu Cys Arg Cys His 
        195                 200                 205             


Asn Leu Pro Val Leu Gln Leu Leu Arg Ser Ala His Leu Arg Gly Phe 
    210                 215                 220                 


Pro Pro Gly Leu Leu Arg Leu Gly Ala Gln Asp Pro Leu Leu Leu Gln 
225                 230                 235                 240 


Met Pro Ser Gly Arg Asp Arg Gly Ala Arg Cys Thr Pro Thr Pro Ala 
                245                 250                 255     


Leu Arg Cys Gly Pro Ala Gly Gly Pro Gly Gly Cys Arg Gly Cys Trp 
            260                 265                 270         


Gly Leu Ser Cys Gln Leu Leu Glu His Ala Val Arg Leu Cys Arg Arg 
        275                 280                 285             


Gly Gly Leu Pro Gly 
    290             


<210>  9717
<211>  1013
<212>  DNA
<213>  Homosapiens

<400>  9717
gtcccccctt tctcacctgc caggtcttgt ggggagggga tcagcctccc acctgggtga     60

agctgggaga gggccagact ggtccatggc cccagcttgg atctttgcac acaatttctc    120

ccctgagcct caggctcctt tttgtaaatt gggtgtagtg tgtccccctt ggagagttgc    180

cctgagggcc gagggacgag gtcagagtgg agtgggtggt aacatgagca gcaggggtca    240

caggagtggg ggcggaggcc acagccaatg tctcctgagt gcttgggcag gcactgttga    300

agcctcatga tttatgtcca ttcttcctcc acacggtgtc cacacaccca tttcaccatg    360

aggaagcagg cacagatgcc ccccgcctga gctcacacag ccagggggag gagggctggg    420

ttccaaaaca agtctagatg ggctctgggg tccagctcac aggcccactc agagtgggtg    480

tcaggcgact gttggtcaat tccttcctta tctggtggcc ccatcagcct ggagaggaag    540

gctcttcctg aatcactcag tgaggcttcc atgcccctct tttcctttta tcagctcgga    600

gcccaagatc ctcttctcct acaaatgcca agtggacgag acagaggagc cagatgtaca    660

cctaccccag ccctacgctg tggcccggcg ggagggcctg gaggctgcag gggctgctgg    720

ggcctcagct gccagctact cgagcacgca gttcgactct gccggcgggg tggcctacct    780

ggatgacatc gcttccatgc cctgccacac tggcagcatc aacagcacag acagcgagcg    840

ctggaaggcc atcaatgcct gagggcagct gccagggcct ggcagggctg gctctcccaa    900

tgcctccatc ccatccccat ggtgctttgg cctcctcaaa gcatccacca tggtggatgg    960

actgaagtgt gtatattttc ttgatctatt ttttaataaa aaggaaaagg agc          1013


<210>  9718
<211>  103
<212>  PRT
<213>  Homosapiens

<400>  9718

Met Tyr Thr Tyr Pro Ser Pro Thr Leu Trp Pro Gly Gly Arg Ala Trp 
1               5                   10                  15      


Arg Leu Gln Gly Leu Leu Gly Pro Gln Leu Pro Ala Thr Arg Ala Arg 
            20                  25                  30          


Ser Ser Thr Leu Pro Ala Gly Trp Pro Thr Trp Met Thr Ser Leu Pro 
        35                  40                  45              


Cys Pro Ala Thr Leu Ala Ala Ser Thr Ala Gln Thr Ala Ser Ala Gly 
    50                  55                  60                  


Arg Pro Ser Met Pro Glu Gly Ser Cys Gln Gly Leu Ala Gly Leu Ala 
65                  70                  75                  80  


Leu Pro Met Pro Pro Ser His Pro His Gly Ala Leu Ala Ser Ser Lys 
                85                  90                  95      


His Pro Pro Trp Trp Met Asp 
            100             


<210>  9719
<211>  882
<212>  DNA
<213>  Homosapiens

<400>  9719
tggccgtttt cgcaatttgg gctggacgaa aaagacggtc ttgctttccc ggtcgccgct     60

gtcgggaagg gctgcagggt gtccgcgaga cccgcggccc ggcgagctga ccccgcctcg    120

cctttcctgc ctagccctca ttccacggag ccggtcgcgc ccggtccttg cgcgacgctt    180

cccggcccag gccgcctggt ctggcgctgg aggccggagt cccgcggcct gtgctggatc    240

cgcgcacacc cagtggcggc ggatgggcgg ccggggcggc cggggcggcc ggtcctgagc    300

gcggcccggg ctgtcagggc tggctgctgg cgggatggac accctggagg aggtgacttg    360

ggccaatggg agcacagcgc tacccccacc cctggcacca aacatcagtg tgcctcatcg    420

ctgcctgctg ctgctctacg aagacattgg cacctccagg gtccggtact gggacctctt    480

gctgctcatc cccaatgtgc tcttcctcat cttcctgctc tggaagcttc catctgctcg    540

ggcgaagatc cgcatcacct ccagccccat ttttatcacc ttctacatcc tggtgtttgt    600

ggtggcgctg gtgggcattg cccgggccgt ggtatccatg acggtgagca cctcgaacgc    660

tgcaactgtt gctgataaga tcctgtggga gatcacccgc ttcttcctgc tggccatcga    720

gctgagtgtg atcatcctgg gcctggcctt tggtgtgtgt accgctgggc tcttgggccc    780

tggcgatgct ctcccctgcc cctccctggc tgtgggctga ctctggagtg gtcacctggg    840

ctggctcctg cctgctgacc agcatgtttc ttccaggcca cc                       882


<210>  9720
<211>  161
<212>  PRT
<213>  Homosapiens

<400>  9720

Met Asp Thr Leu Glu Glu Val Thr Trp Ala Asn Gly Ser Thr Ala Leu 
1               5                   10                  15      


Pro Pro Pro Leu Ala Pro Asn Ile Ser Val Pro His Arg Cys Leu Leu 
            20                  25                  30          


Leu Leu Tyr Glu Asp Ile Gly Thr Ser Arg Val Arg Tyr Trp Asp Leu 
        35                  40                  45              


Leu Leu Leu Ile Pro Asn Val Leu Phe Leu Ile Phe Leu Leu Trp Lys 
    50                  55                  60                  


Leu Pro Ser Ala Arg Ala Lys Ile Arg Ile Thr Ser Ser Pro Ile Phe 
65                  70                  75                  80  


Ile Thr Phe Tyr Ile Leu Val Phe Val Val Ala Leu Val Gly Ile Ala 
                85                  90                  95      


Arg Ala Val Val Ser Met Thr Val Ser Thr Ser Asn Ala Ala Thr Val 
            100                 105                 110         


Ala Asp Lys Ile Leu Trp Glu Ile Thr Arg Phe Phe Leu Leu Ala Ile 
        115                 120                 125             


Glu Leu Ser Val Ile Ile Leu Gly Leu Ala Phe Gly Val Cys Thr Ala 
    130                 135                 140                 


Gly Leu Leu Gly Pro Gly Asp Ala Leu Pro Cys Pro Ser Leu Ala Val 
145                 150                 155                 160 


Gly 
    


<210>  9721
<211>  3455
<212>  DNA
<213>  Homosapiens

<400>  9721
gtcacgtgaa ccacttttcg cgcgaaacct ggttgttgct gtagtggcgg agaggatcgt     60

ggtactgcta tggcggaatc atcggaatcc ttcaccatgg catccagccc ggcccagcgt    120

cggcgaggca atgatcctct cacctccagc cctggccgaa gctcccggcg tactgatgcc    180

ctcacctcca gccctggccg tgaccttcca ccatttgagg atgagtccga ggggctccta    240

ggcacagagg ggcccctgga ggaagaagag gatggagagg agctcattgg agatggcatg    300

gaaagggact accgcgccat cccagagctg gacgcctatg aggccgaggg actggctctg    360

gatgatgagg acgtagagga gctgacggcc agtcagaggg aggcagcaga gcgggccatg    420

cggcagcgtg accgggaggc tggccggggc ctgggccgca tgcgccgtgg gctcctgtat    480

gacagcgatg aggaggacga ggagcgccct gcccgcaagc gccgccaggt ggagcgggcc    540

acggaggacg gcgaggagga cgaggagatg atcgagagca tcgagaacct ggaggatctc    600

aaaggccact ctgtgcgcga gtgggtgagc atggcgggcc cccggctgga gatccaccac    660

cgcttcaaga acttcctgcg cactcacgtc gacagccacg gccacaacgt cttcaaggag    720

cgcatcagcg acatgtgcaa agagaaccgt gagagcctgg tggtgaacta tgaggacttg    780

gcagccaggg agcacgtgct ggcctacttc ctgcctgagg caccggcgga gctgctgcag    840

atctttgatg aggctgccct ggaggtggta ctggccatgt accccaagta cgaccgcatc    900

accaaccaca tccatgtccg catctcccac ctgcctctgg tggaggagct gcgctcgctg    960

aggcagctgc atctgaacca gctgatccgc accagtgggg tggtgaccag ctgcactggc   1020

gtcctgcccc agctcagcat ggtcaagtac aactgcaaca agtgcaattt cgtcctgggt   1080

cctttctgcc agtcccagaa ccaggaggtg aaaccaggct cctgtcctga gtgccagtcg   1140

gccggcccct ttgaggtcaa catggaggag accatctatc agaactacca gcgtatccga   1200

atccaggaga gtccaggcaa agtggcggct ggccggctgc cccgctccaa ggacgccatt   1260

ctcctcgcag atctggtgga cagctgcaag ccaggagacg agatagagct gactggcatc   1320

tatcacaaca actatgatgg ctccctcaac actgccaatg gcttccctgt ctttgccact   1380

gtcatcctag ccaaccacgt ggccaagaag gacaacaagg ttgctgtagg ggaactgacc   1440

gatgaagatg tgaagatgat cactagcctc tccaaggatc agcagatcgg agagaagatc   1500

tttgccagca ttgctccttc catctatggt catgaagaca tcaagagagg cctggctctg   1560

gccctgttcg gaggggagcc caaaaaccca ggtggcaagc acaaggtacg tggtgatatc   1620

aacgtgctct tgtgcggaga ccctggcaca gcgaagtcgc agtttctcaa gtatattgag   1680

aaagtgtcca gccgagccat cttcaccact ggccaggggg cgtcggctgt gggcctcacg   1740

gcgtatgtcc agcggcaccc tgtcagcagg gagtggacct tggaggctgg ggccctggtt   1800

ctggctgacc gaggagtgtg tctcattgat gaatttgaca agatgaatga ccaggacaga   1860

accagcatcc atgaggccat ggagcaacag agcatctcca tctcgaaggc tggcatcgtc   1920

acctccctgc aggctcgctg cacggtcatt gctgccgcca accccatagg agggcgctac   1980

gacccctcgc tgactttctc tgagaacgtg gacctcacag agcccatcat ctcacgcttt   2040

gacatcctgt gtgtggtgag ggacaccgtg gacccagtcc aggacgagat gctggcccgc   2100

ttcgtggtgg gcagccacgt cagacaccac cccagcaaca aggaggagga ggggctggcc   2160

aatggcagcg ctgctgagcc cgccatgccc aacacgtatg gcgtggagcc cctgccccag   2220

gaggtcctga agaagtacat catctacgcc aaggagaggg tccacccgaa gctcaaccag   2280

atggaccagg acaaggtggc caagatgtac agtgacctga ggaaagaatc tatggcgaca   2340

ggcagcatcc ccattacggt gcggcacatc gagtccatga tccgcatggc ggaggcccac   2400

gcgcgcatcc atctgcggga ctatgtgatc gaagacgacg tcaacatggc catccgcgtg   2460

atgctggaga gcttcataga cacacagaag ttcagcgtca tgcgcagcat gcgcaagact   2520

tttgcccgct acctttcatt ccggcgtgac aacaatgagc tgttgctctt catactgaag   2580

cagttagtgg cagagcaggt gacatatcag cgcaaccgct ttggggccca gcaggacact   2640

attgaggtcc ctgagaagga cttggtggat aaggctcgtc agatcaacat ccacaacctc   2700

tctgcatttt atgacagtga gctcttcagg atgaacaagt tcagccacga cctgaaaagg   2760

aaaatgatcc tgcagcagtt ctgaggccct atgccatcca taaggattcc ttgggattct   2820

ggtttggggt ggtcagtgcc ctctgtgctt tatggacaca aaaccagagc acttgatgaa   2880

ctcggggtac tagggtcagg gcttatagca ggatgtctgg ctgcacctgg catgactgtt   2940

tgtttctcca agcctgcttt gtgcttctca cctttgggtg ggatgccttg ccagtgtgtc   3000

ttacttggtt gctgaacatc ttgccacctc cgagtgcttt gtctccactc agtaccttgg   3060

atcagagctg ctgagttcag gatgcctgcg tgtggtttag gtgttagcct tcttacatgg   3120

atgtcaggag agctgctgcc ctcttggcgt gagttgcgta ttcaggctgc ttttgctgcc   3180

tttggccaga gagctggttg aagatgtttg taatcgtttt cagtctcctg caggtttctg   3240

tgcccctgtg gtggaagagg gcacgacagt gccagcgcag cgttctgggc tcctcagtcg   3300

caggggtggg atgtgagtca tgcggattat ccactcgcca cagttatcag ctgccattgc   3360

tccctgtctg tttccccact ctcttatttg tgcattcggt ttggtttctg tagttttaat   3420

ttttaataaa gttgaataaa atataaacgc tggta                              3455


<210>  9722
<211>  904
<212>  PRT
<213>  Homosapiens

<400>  9722

Met Ala Glu Ser Ser Glu Ser Phe Thr Met Ala Ser Ser Pro Ala Gln 
1               5                   10                  15      


Arg Arg Arg Gly Asn Asp Pro Leu Thr Ser Ser Pro Gly Arg Ser Ser 
            20                  25                  30          


Arg Arg Thr Asp Ala Leu Thr Ser Ser Pro Gly Arg Asp Leu Pro Pro 
        35                  40                  45              


Phe Glu Asp Glu Ser Glu Gly Leu Leu Gly Thr Glu Gly Pro Leu Glu 
    50                  55                  60                  


Glu Glu Glu Asp Gly Glu Glu Leu Ile Gly Asp Gly Met Glu Arg Asp 
65                  70                  75                  80  


Tyr Arg Ala Ile Pro Glu Leu Asp Ala Tyr Glu Ala Glu Gly Leu Ala 
                85                  90                  95      


Leu Asp Asp Glu Asp Val Glu Glu Leu Thr Ala Ser Gln Arg Glu Ala 
            100                 105                 110         


Ala Glu Arg Ala Met Arg Gln Arg Asp Arg Glu Ala Gly Arg Gly Leu 
        115                 120                 125             


Gly Arg Met Arg Arg Gly Leu Leu Tyr Asp Ser Asp Glu Glu Asp Glu 
    130                 135                 140                 


Glu Arg Pro Ala Arg Lys Arg Arg Gln Val Glu Arg Ala Thr Glu Asp 
145                 150                 155                 160 


Gly Glu Glu Asp Glu Glu Met Ile Glu Ser Ile Glu Asn Leu Glu Asp 
                165                 170                 175     


Leu Lys Gly His Ser Val Arg Glu Trp Val Ser Met Ala Gly Pro Arg 
            180                 185                 190         


Leu Glu Ile His His Arg Phe Lys Asn Phe Leu Arg Thr His Val Asp 
        195                 200                 205             


Ser His Gly His Asn Val Phe Lys Glu Arg Ile Ser Asp Met Cys Lys 
    210                 215                 220                 


Glu Asn Arg Glu Ser Leu Val Val Asn Tyr Glu Asp Leu Ala Ala Arg 
225                 230                 235                 240 


Glu His Val Leu Ala Tyr Phe Leu Pro Glu Ala Pro Ala Glu Leu Leu 
                245                 250                 255     


Gln Ile Phe Asp Glu Ala Ala Leu Glu Val Val Leu Ala Met Tyr Pro 
            260                 265                 270         


Lys Tyr Asp Arg Ile Thr Asn His Ile His Val Arg Ile Ser His Leu 
        275                 280                 285             


Pro Leu Val Glu Glu Leu Arg Ser Leu Arg Gln Leu His Leu Asn Gln 
    290                 295                 300                 


Leu Ile Arg Thr Ser Gly Val Val Thr Ser Cys Thr Gly Val Leu Pro 
305                 310                 315                 320 


Gln Leu Ser Met Val Lys Tyr Asn Cys Asn Lys Cys Asn Phe Val Leu 
                325                 330                 335     


Gly Pro Phe Cys Gln Ser Gln Asn Gln Glu Val Lys Pro Gly Ser Cys 
            340                 345                 350         


Pro Glu Cys Gln Ser Ala Gly Pro Phe Glu Val Asn Met Glu Glu Thr 
        355                 360                 365             


Ile Tyr Gln Asn Tyr Gln Arg Ile Arg Ile Gln Glu Ser Pro Gly Lys 
    370                 375                 380                 


Val Ala Ala Gly Arg Leu Pro Arg Ser Lys Asp Ala Ile Leu Leu Ala 
385                 390                 395                 400 


Asp Leu Val Asp Ser Cys Lys Pro Gly Asp Glu Ile Glu Leu Thr Gly 
                405                 410                 415     


Ile Tyr His Asn Asn Tyr Asp Gly Ser Leu Asn Thr Ala Asn Gly Phe 
            420                 425                 430         


Pro Val Phe Ala Thr Val Ile Leu Ala Asn His Val Ala Lys Lys Asp 
        435                 440                 445             


Asn Lys Val Ala Val Gly Glu Leu Thr Asp Glu Asp Val Lys Met Ile 
    450                 455                 460                 


Thr Ser Leu Ser Lys Asp Gln Gln Ile Gly Glu Lys Ile Phe Ala Ser 
465                 470                 475                 480 


Ile Ala Pro Ser Ile Tyr Gly His Glu Asp Ile Lys Arg Gly Leu Ala 
                485                 490                 495     


Leu Ala Leu Phe Gly Gly Glu Pro Lys Asn Pro Gly Gly Lys His Lys 
            500                 505                 510         


Val Arg Gly Asp Ile Asn Val Leu Leu Cys Gly Asp Pro Gly Thr Ala 
        515                 520                 525             


Lys Ser Gln Phe Leu Lys Tyr Ile Glu Lys Val Ser Ser Arg Ala Ile 
    530                 535                 540                 


Phe Thr Thr Gly Gln Gly Ala Ser Ala Val Gly Leu Thr Ala Tyr Val 
545                 550                 555                 560 


Gln Arg His Pro Val Ser Arg Glu Trp Thr Leu Glu Ala Gly Ala Leu 
                565                 570                 575     


Val Leu Ala Asp Arg Gly Val Cys Leu Ile Asp Glu Phe Asp Lys Met 
            580                 585                 590         


Asn Asp Gln Asp Arg Thr Ser Ile His Glu Ala Met Glu Gln Gln Ser 
        595                 600                 605             


Ile Ser Ile Ser Lys Ala Gly Ile Val Thr Ser Leu Gln Ala Arg Cys 
    610                 615                 620                 


Thr Val Ile Ala Ala Ala Asn Pro Ile Gly Gly Arg Tyr Asp Pro Ser 
625                 630                 635                 640 


Leu Thr Phe Ser Glu Asn Val Asp Leu Thr Glu Pro Ile Ile Ser Arg 
                645                 650                 655     


Phe Asp Ile Leu Cys Val Val Arg Asp Thr Val Asp Pro Val Gln Asp 
            660                 665                 670         


Glu Met Leu Ala Arg Phe Val Val Gly Ser His Val Arg His His Pro 
        675                 680                 685             


Ser Asn Lys Glu Glu Glu Gly Leu Ala Asn Gly Ser Ala Ala Glu Pro 
    690                 695                 700                 


Ala Met Pro Asn Thr Tyr Gly Val Glu Pro Leu Pro Gln Glu Val Leu 
705                 710                 715                 720 


Lys Lys Tyr Ile Ile Tyr Ala Lys Glu Arg Val His Pro Lys Leu Asn 
                725                 730                 735     


Gln Met Asp Gln Asp Lys Val Ala Lys Met Tyr Ser Asp Leu Arg Lys 
            740                 745                 750         


Glu Ser Met Ala Thr Gly Ser Ile Pro Ile Thr Val Arg His Ile Glu 
        755                 760                 765             


Ser Met Ile Arg Met Ala Glu Ala His Ala Arg Ile His Leu Arg Asp 
    770                 775                 780                 


Tyr Val Ile Glu Asp Asp Val Asn Met Ala Ile Arg Val Met Leu Glu 
785                 790                 795                 800 


Ser Phe Ile Asp Thr Gln Lys Phe Ser Val Met Arg Ser Met Arg Lys 
                805                 810                 815     


Thr Phe Ala Arg Tyr Leu Ser Phe Arg Arg Asp Asn Asn Glu Leu Leu 
            820                 825                 830         


Leu Phe Ile Leu Lys Gln Leu Val Ala Glu Gln Val Thr Tyr Gln Arg 
        835                 840                 845             


Asn Arg Phe Gly Ala Gln Gln Asp Thr Ile Glu Val Pro Glu Lys Asp 
    850                 855                 860                 


Leu Val Asp Lys Ala Arg Gln Ile Asn Ile His Asn Leu Ser Ala Phe 
865                 870                 875                 880 


Tyr Asp Ser Glu Leu Phe Arg Met Asn Lys Phe Ser His Asp Leu Lys 
                885                 890                 895     


Arg Lys Met Ile Leu Gln Gln Phe 
            900                 


<210>  9723
<211>  3155
<212>  DNA
<213>  Homosapiens

<400>  9723
acttttcgcg cgaaacctgg ttgttgctgt agtggcggag aggatcgtgg tactgctatg     60

gcggaatcat cggaatcctt caccatggca tccagcccgg cccagcgtcg gcgaggcaat    120

gatcctctca cctccagccc tggccggggc ctgggccgca tgcgccgtgg gctcctgtat    180

gacagcgatg aggaggacga ggagcgccct gcccgcaagc gccgccaggt ggagcgggcc    240

acggaggacg gcgaggagga cgaggagatg atcgagagca tcgagaacct ggaggatctc    300

aaaggccact ctgtgcgcga gtgggtgagc atggcgggcc cccggctgga gatccaccac    360

cgcttcaaga acttcctgcg cactcacgtc gacagccacg gccacaacgt cttcaaggag    420

cgcatcagcg acatgtgcaa agagaaccgt gagagcctgg tggtgaacta tgaggacttg    480

gcagccaggg agcacgtgct ggcctacttc ctgcctgagg caccggcgga gctgctgcag    540

atctttgatg aggctgccct ggaggtggta ctggccatgt accccaagta cgaccgcatc    600

accaaccaca tccatgtccg catctcccac ctgcctctgg tggaggagct gcgctcgctg    660

aggcagctgc atctgaacca gctgatccgc accagtgggg tggtgaccag ctgcactggc    720

gtcctgcccc agctcagcat ggtcaagtac aactgcaaca agtgcaattt cgtcctgggt    780

cctttctgcc agtcccagaa ccaggaggtg aaaccaggct cctgtcctga gtgccagtcg    840

gccggcccct ttgaggtcaa catggaggag accatctatc agaactacca gcgtatccga    900

atccaggaga gtccaggcaa agtggcggct ggccggctgc cccgctccaa ggacgccatt    960

ctcctcgcag atctggtgga cagctgcaag ccaggagacg agatagagct gactggcatc   1020

tatcacaaca actatgatgg ctccctcaac actgccaatg gcttccctgt ctttgccact   1080

gtcatcctag ccaaccacgt ggccaagaag gacaacaagg ttgctgtagg ggaactgacc   1140

gatgaagatg tgaagatgat cactagcctc tccaaggatc agcagatcgg agagaagatc   1200

tttgccagca ttgctccttc catctatggt catgaagaca tcaagagagg cctggctctg   1260

gccctgttcg gaggggagcc caaaaaccca ggtggcaagc acaaggtacg tggtgatatc   1320

aacgtgctct tgtgcggaga ccctggcaca gcgaagtcgc agtttctcaa gtatattgag   1380

aaagtgtcca gccgagccat cttcaccact ggccaggggg cgtcggctgt gggcctcacg   1440

gcgtatgtcc agcggcaccc tgtcagcagg gagtggacct tggaggctgg ggccctggtt   1500

ctggctgacc gaggagtgtg tctcattgat gaatttgaca agatgaatga ccaggacaga   1560

accagcatcc atgaggccat ggagcaacag agcatctcca tctcgaaggc tggcatcgtc   1620

acctccctgc aggctcgctg cacggtcatt gctgccgcca accccatagg agggcgctac   1680

gacccctcgc tgactttctc tgagaacgtg gacctcacag agcccatcat ctcacgcttt   1740

gacatcctgt gtgtggtgag ggacaccgtg gacccagtcc aggacgagat gctggcccgc   1800

ttcgtggtgg gcagccacgt cagacaccac cccagcaaca aggaggagga ggggctggcc   1860

aatggcagcg ctgctgagcc cgccatgccc aacacgtatg gcgtggagcc cctgccccag   1920

gaggtcctga agaagtacat catctacgcc aaggagaggg tccacccgaa gctcaaccag   1980

atggaccagg acaaggtggc caagatgtac agtgacctga ggaaagaatc tatggcgaca   2040

ggcagcatcc ccattacggt gcggcacatc gagtccatga tccgcatggc ggaggcccac   2100

gcgcgcatcc atctgcggga ctatgtgatc gaagacgacg tcaacatggc catccgcgtg   2160

atgctggaga gcttcataga cacacagaag ttcagcgtca tgcgcagcat gcgcaagact   2220

tttgcccgct acctttcatt ccggcgtgac aacaatgagc tgttgctctt catactgaag   2280

cagttagtgg cagagcaggt gacatatcag cgcaaccgct ttggggccca gcaggacact   2340

attgaggtcc ctgagaagga cttggtggat aaggctcgtc agatcaacat ccacaacctc   2400

tctgcatttt atgacagtga gctcttcagg atgaacaagt tcagccacga cctgaaaagg   2460

aaaatgatcc tgcagcagtt ctgaggccct atgccatcca taaggattcc ttgggattct   2520

ggtttggggt ggtcagtgcc ctctgtgctt tatggacaca aaaccagagc acttgatgaa   2580

ctcggggtac tagggtcagg gcttatagca ggatgtctgg ctgcacctgg catgactgtt   2640

tgtttctcca agcctgcttt gtgcttctca cctttgggtg ggatgccttg ccagtgtgtc   2700

ttacttggtt gctgaacatc ttgccacctc cgagtgcttt gtctccactc agtaccttgg   2760

atcagagctg ctgagttcag gatgcctgcg tgtggtttag gtgttagcct tcttacatgg   2820

atgtcaggag agctgctgcc ctcttggcgt gagttgcgta ttcaggctgc ttttgctgcc   2880

tttggccaga gagctggttg aagatgtttg taatcgtttt cagtctcctg caggtttctg   2940

tgcccctgtg gtggaagagg gcacgacagt gccagcgcag cgttctgggc tcctcagtcg   3000

caggggtggg atgtgagtca tgcggattat ccactcgcca cagttatcag ctgccattgc   3060

tccctgtctg tttccccact ctcttatttg tgcattcggt ttggtttctg tagttttaat   3120

ttttaataaa gttgaataaa atataaacgc tggta                              3155


<210>  9724
<211>  808
<212>  PRT
<213>  Homosapiens

<400>  9724

Met Ala Glu Ser Ser Glu Ser Phe Thr Met Ala Ser Ser Pro Ala Gln 
1               5                   10                  15      


Arg Arg Arg Gly Asn Asp Pro Leu Thr Ser Ser Pro Gly Arg Gly Leu 
            20                  25                  30          


Gly Arg Met Arg Arg Gly Leu Leu Tyr Asp Ser Asp Glu Glu Asp Glu 
        35                  40                  45              


Glu Arg Pro Ala Arg Lys Arg Arg Gln Val Glu Arg Ala Thr Glu Asp 
    50                  55                  60                  


Gly Glu Glu Asp Glu Glu Met Ile Glu Ser Ile Glu Asn Leu Glu Asp 
65                  70                  75                  80  


Leu Lys Gly His Ser Val Arg Glu Trp Val Ser Met Ala Gly Pro Arg 
                85                  90                  95      


Leu Glu Ile His His Arg Phe Lys Asn Phe Leu Arg Thr His Val Asp 
            100                 105                 110         


Ser His Gly His Asn Val Phe Lys Glu Arg Ile Ser Asp Met Cys Lys 
        115                 120                 125             


Glu Asn Arg Glu Ser Leu Val Val Asn Tyr Glu Asp Leu Ala Ala Arg 
    130                 135                 140                 


Glu His Val Leu Ala Tyr Phe Leu Pro Glu Ala Pro Ala Glu Leu Leu 
145                 150                 155                 160 


Gln Ile Phe Asp Glu Ala Ala Leu Glu Val Val Leu Ala Met Tyr Pro 
                165                 170                 175     


Lys Tyr Asp Arg Ile Thr Asn His Ile His Val Arg Ile Ser His Leu 
            180                 185                 190         


Pro Leu Val Glu Glu Leu Arg Ser Leu Arg Gln Leu His Leu Asn Gln 
        195                 200                 205             


Leu Ile Arg Thr Ser Gly Val Val Thr Ser Cys Thr Gly Val Leu Pro 
    210                 215                 220                 


Gln Leu Ser Met Val Lys Tyr Asn Cys Asn Lys Cys Asn Phe Val Leu 
225                 230                 235                 240 


Gly Pro Phe Cys Gln Ser Gln Asn Gln Glu Val Lys Pro Gly Ser Cys 
                245                 250                 255     


Pro Glu Cys Gln Ser Ala Gly Pro Phe Glu Val Asn Met Glu Glu Thr 
            260                 265                 270         


Ile Tyr Gln Asn Tyr Gln Arg Ile Arg Ile Gln Glu Ser Pro Gly Lys 
        275                 280                 285             


Val Ala Ala Gly Arg Leu Pro Arg Ser Lys Asp Ala Ile Leu Leu Ala 
    290                 295                 300                 


Asp Leu Val Asp Ser Cys Lys Pro Gly Asp Glu Ile Glu Leu Thr Gly 
305                 310                 315                 320 


Ile Tyr His Asn Asn Tyr Asp Gly Ser Leu Asn Thr Ala Asn Gly Phe 
                325                 330                 335     


Pro Val Phe Ala Thr Val Ile Leu Ala Asn His Val Ala Lys Lys Asp 
            340                 345                 350         


Asn Lys Val Ala Val Gly Glu Leu Thr Asp Glu Asp Val Lys Met Ile 
        355                 360                 365             


Thr Ser Leu Ser Lys Asp Gln Gln Ile Gly Glu Lys Ile Phe Ala Ser 
    370                 375                 380                 


Ile Ala Pro Ser Ile Tyr Gly His Glu Asp Ile Lys Arg Gly Leu Ala 
385                 390                 395                 400 


Leu Ala Leu Phe Gly Gly Glu Pro Lys Asn Pro Gly Gly Lys His Lys 
                405                 410                 415     


Val Arg Gly Asp Ile Asn Val Leu Leu Cys Gly Asp Pro Gly Thr Ala 
            420                 425                 430         


Lys Ser Gln Phe Leu Lys Tyr Ile Glu Lys Val Ser Ser Arg Ala Ile 
        435                 440                 445             


Phe Thr Thr Gly Gln Gly Ala Ser Ala Val Gly Leu Thr Ala Tyr Val 
    450                 455                 460                 


Gln Arg His Pro Val Ser Arg Glu Trp Thr Leu Glu Ala Gly Ala Leu 
465                 470                 475                 480 


Val Leu Ala Asp Arg Gly Val Cys Leu Ile Asp Glu Phe Asp Lys Met 
                485                 490                 495     


Asn Asp Gln Asp Arg Thr Ser Ile His Glu Ala Met Glu Gln Gln Ser 
            500                 505                 510         


Ile Ser Ile Ser Lys Ala Gly Ile Val Thr Ser Leu Gln Ala Arg Cys 
        515                 520                 525             


Thr Val Ile Ala Ala Ala Asn Pro Ile Gly Gly Arg Tyr Asp Pro Ser 
    530                 535                 540                 


Leu Thr Phe Ser Glu Asn Val Asp Leu Thr Glu Pro Ile Ile Ser Arg 
545                 550                 555                 560 


Phe Asp Ile Leu Cys Val Val Arg Asp Thr Val Asp Pro Val Gln Asp 
                565                 570                 575     


Glu Met Leu Ala Arg Phe Val Val Gly Ser His Val Arg His His Pro 
            580                 585                 590         


Ser Asn Lys Glu Glu Glu Gly Leu Ala Asn Gly Ser Ala Ala Glu Pro 
        595                 600                 605             


Ala Met Pro Asn Thr Tyr Gly Val Glu Pro Leu Pro Gln Glu Val Leu 
    610                 615                 620                 


Lys Lys Tyr Ile Ile Tyr Ala Lys Glu Arg Val His Pro Lys Leu Asn 
625                 630                 635                 640 


Gln Met Asp Gln Asp Lys Val Ala Lys Met Tyr Ser Asp Leu Arg Lys 
                645                 650                 655     


Glu Ser Met Ala Thr Gly Ser Ile Pro Ile Thr Val Arg His Ile Glu 
            660                 665                 670         


Ser Met Ile Arg Met Ala Glu Ala His Ala Arg Ile His Leu Arg Asp 
        675                 680                 685             


Tyr Val Ile Glu Asp Asp Val Asn Met Ala Ile Arg Val Met Leu Glu 
    690                 695                 700                 


Ser Phe Ile Asp Thr Gln Lys Phe Ser Val Met Arg Ser Met Arg Lys 
705                 710                 715                 720 


Thr Phe Ala Arg Tyr Leu Ser Phe Arg Arg Asp Asn Asn Glu Leu Leu 
                725                 730                 735     


Leu Phe Ile Leu Lys Gln Leu Val Ala Glu Gln Val Thr Tyr Gln Arg 
            740                 745                 750         


Asn Arg Phe Gly Ala Gln Gln Asp Thr Ile Glu Val Pro Glu Lys Asp 
        755                 760                 765             


Leu Val Asp Lys Ala Arg Gln Ile Asn Ile His Asn Leu Ser Ala Phe 
    770                 775                 780                 


Tyr Asp Ser Glu Leu Phe Arg Met Asn Lys Phe Ser His Asp Leu Lys 
785                 790                 795                 800 


Arg Lys Met Ile Leu Gln Gln Phe 
                805             


<210>  9725
<211>  1744
<212>  DNA
<213>  Homosapiens

<400>  9725
aagaacccag gctctgtcac ccactgtgtt cttggttttt cctcctgggg aagcagttat     60

gctttctgtc taaattaggc tattttgggc cctggttagg gtaagctctt tgctgtctca    120

gacagcaggt gctaagtacc cacctatgtc ttcctcttcc actgccctca tccccttctg    180

ccatcagagc agcctggggt ccctgagatg ggaggatagg ggaatccacc ctgatggagg    240

tgctcccctg tgtttcagga gggcgctacg acccctcgct gactttctct gagaacgtgg    300

acctcacaga gcccatcatc tcacgctttg acatcctgtg tgtggtgagg gacaccgtgg    360

acccagtcca ggacgagatg ctggcccgct tcgtggtggg cagccacgtc agacaccacc    420

ccagcaacaa ggaggaggag gggctggcca atggcagcgc tgctgagccc gccatgccca    480

acacgtatgg cgtggagccc ctgccccagg aggtcctgaa gaagtacatc atctacgcca    540

aggagagggt ccacccgaag ctcaaccaga tggaccagga caaggtggcc aagatgtaca    600

gtgacctgag gaaagaatct atggcgacag gcagcatccc cattacggtg cggcacatcg    660

agtccatgat ccgcatggcg gaggcccacg cgcgcatcca tctgcgggac tatgtgatcg    720

aagacgacgt caacatggcc atccgcgtga tgctggagag cttcatagac acacagaagt    780

tcagcgtcat gcgcagcatg cgcaagactt ttgcccgcta cctttcattc cggcgtgaca    840

acaatgagct gttgctcttc atactgaagc agttagtggc agagcaggtg acatatcagc    900

gcaaccgctt tggggcccag caggacacta ttgaggtccc tgagaaggac ttggtggata    960

aggctcgtca gatcaacatc cacaacctct ctgcatttta tgacagtgag ctcttcagga   1020

tgaacaagtt cagccacgac ctgaaaagga aaatgatcct gcagcagttc tgaggcccta   1080

tgccatccat aaggattcct tgggattctg gtttggggtg gtcagtgccc tctgtgcttt   1140

atggacacaa aaccagagca cttgatgaac tcggggtact agggtcaggg cttatagcag   1200

gatgtctggc tgcacctggc atgactgttt gtttctccaa gcctgctttg tgcttctcac   1260

ctttgggtgg gatgccttgc cagtgtgtct tacttggttg ctgaacatct tgccacctcc   1320

gagtgctttg tctccactca gtaccttgga tcagagctgc tgagttcagg atgcctgcgt   1380

gtggtttagg tgttagcctt cttacatgga tgtcaggaga gctgctgccc tcttggcgtg   1440

agttgcgtat tcaggctgct tttgctgcct ttggccagag agctggttga agatgtttgt   1500

aatcgttttc agtctcctgc aggtttctgt gcccctgtgg tggaagaggg cacgacagtg   1560

ccagcgcagc gttctgggct cctcagtcgc aggggtggga tgtgagtcat gcggattatc   1620

cactcgccac agttatcagc tgccattgct ccctgtctgt ttccccactc tcttatttgt   1680

gcattcggtt tggtttctgt agttttaatt tttaataaag ttgaataaaa tataaacgct   1740

ggta                                                                1744


<210>  9726
<211>  279
<212>  PRT
<213>  Homosapiens

<400>  9726

Met Glu Val Leu Pro Cys Val Ser Gly Gly Arg Tyr Asp Pro Ser Leu 
1               5                   10                  15      


Thr Phe Ser Glu Asn Val Asp Leu Thr Glu Pro Ile Ile Ser Arg Phe 
            20                  25                  30          


Asp Ile Leu Cys Val Val Arg Asp Thr Val Asp Pro Val Gln Asp Glu 
        35                  40                  45              


Met Leu Ala Arg Phe Val Val Gly Ser His Val Arg His His Pro Ser 
    50                  55                  60                  


Asn Lys Glu Glu Glu Gly Leu Ala Asn Gly Ser Ala Ala Glu Pro Ala 
65                  70                  75                  80  


Met Pro Asn Thr Tyr Gly Val Glu Pro Leu Pro Gln Glu Val Leu Lys 
                85                  90                  95      


Lys Tyr Ile Ile Tyr Ala Lys Glu Arg Val His Pro Lys Leu Asn Gln 
            100                 105                 110         


Met Asp Gln Asp Lys Val Ala Lys Met Tyr Ser Asp Leu Arg Lys Glu 
        115                 120                 125             


Ser Met Ala Thr Gly Ser Ile Pro Ile Thr Val Arg His Ile Glu Ser 
    130                 135                 140                 


Met Ile Arg Met Ala Glu Ala His Ala Arg Ile His Leu Arg Asp Tyr 
145                 150                 155                 160 


Val Ile Glu Asp Asp Val Asn Met Ala Ile Arg Val Met Leu Glu Ser 
                165                 170                 175     


Phe Ile Asp Thr Gln Lys Phe Ser Val Met Arg Ser Met Arg Lys Thr 
            180                 185                 190         


Phe Ala Arg Tyr Leu Ser Phe Arg Arg Asp Asn Asn Glu Leu Leu Leu 
        195                 200                 205             


Phe Ile Leu Lys Gln Leu Val Ala Glu Gln Val Thr Tyr Gln Arg Asn 
    210                 215                 220                 


Arg Phe Gly Ala Gln Gln Asp Thr Ile Glu Val Pro Glu Lys Asp Leu 
225                 230                 235                 240 


Val Asp Lys Ala Arg Gln Ile Asn Ile His Asn Leu Ser Ala Phe Tyr 
                245                 250                 255     


Asp Ser Glu Leu Phe Arg Met Asn Lys Phe Ser His Asp Leu Lys Arg 
            260                 265                 270         


Lys Met Ile Leu Gln Gln Phe 
        275                 


<210>  9727
<211>  559
<212>  DNA
<213>  Homosapiens

<400>  9727
tttatatttt attcaacttt attaaaaatt aaaactacag aaaccaaacc gaatgcacaa     60

ataagagagt ggggaaacag acagggagca atggcagctg ataactgtgg cgagtggata    120

atccgcatga ctcacatccc acccctgcga ctgaggagcc cagaacgctg cgctggcact    180

gtcgtgccct cttccaccac aggggcacag aaacctgcag gagactgaaa acgattacaa    240

acatcttcaa ccagctctct ggccaaaggc agcaaaagca gcctgaatac gcaactcacg    300

ccaagagggc agcagctctc ctgacatcca tgtaagaagg ctaacaccta aaccacacgc    360

aggcatcctg aactcagcag ctctgatcca aggtactgag tggagacaaa gcactcggag    420

gtggcaagat gttcagcaac caaccagaca tcctgctata agccctgacc ctagtacccc    480

gagttcatca agtgctctgg ttttgtgtcc ataaagcaca gagggcactg accaccccaa    540

accagaatcc caaggaatc                                                 559


<210>  9728
<211>  45
<212>  PRT
<213>  Homosapiens

<400>  9728

Met Ala Ala Asp Asn Cys Gly Glu Trp Ile Ile Arg Met Thr His Ile 
1               5                   10                  15      


Pro Pro Leu Arg Leu Arg Ser Pro Glu Arg Cys Ala Gly Thr Val Val 
            20                  25                  30          


Pro Ser Ser Thr Thr Gly Ala Gln Lys Pro Ala Gly Asp 
        35                  40                  45  


<210>  9729
<211>  1980
<212>  DNA
<213>  Homosapiens

<400>  9729
cggcccctga cgcgggcccg ggcgccgcgc cgctgcggct gcaggcggcg acggctacac     60

catgggccgg ctgctgcggg ccgcccggct gccgccgctg ctttcgccgc tgctgcttct    120

gctggttggg ggagcgttcc tgggtgcctg tgtggctggg tctgatgagc ctggcccaga    180

gggcctcacc tccacctccc tgctagacct cctgctgccc actggcttgg agccactgga    240

ctcagaggag cctagtgaga ccatgggcct gggagctggg ctgggagccc ctggctcagg    300

cttccccagc gaagagaatg aagagtctcg gattctgcag ccaccacagt acttctggga    360

agaggaggaa gagctgaatg actcaagtct ggacctggga cccactgcag attatgtttt    420

tcctgactta actgagaagg caggttccat tgaagacacc agccaggctc aagagctgcc    480

aaacctcccc tctcccttgc ccaagatgaa tctggttgag cctccctggc atatgcctcc    540

cagagaggag gaagaagagg aagaggaaga ggaggagagg gagaaggaag aggtagagaa    600

acaagaggag gaggaagagg aggagctgct ccctgtgaat ggatcccaag aagaagccaa    660

gcctcaggtc cgtgactttt ctctcaccag cagcagccag accccagggg ccaccaaaag    720

caggcatgaa gactccgggg accaggcctc atcaggtgtg gaggtggaga gcagcatggg    780

gcccagcttg ctgctgcctt cagtcacccc aactacagtg actccggggg accaggactc    840

caccagccaa gaggcagagg ccacagtgct gccagctgca gggcttgggg tagagttcga    900

ggctcctcag gaagcaagcg aggaagccac tgcaggagca gctggtttgt ctggccagca    960

cgaggaggtg ccggccttgc cttcattccc tcaaaccaca gctcccagtg gggccgagca   1020

cccagatgaa gatccccttg gctctagaac ctcagcctct tccccactgc tcctggccct   1080

ggtggaagag gtgctgcccc gccatggcag tggccaccat ggggcctggc acatctctct   1140

gagcaagccc agcgagaagg agcagcacct tctcatgaca ctggtgggcg agcagggggt   1200

ggtgcccact caagatgtcc tttccatgct gggtgacatc cgcaggagcc tggaggagat   1260

tggcatccag aactattcca caaccagcag ctgccaggcg cgggccagcc aggtgcgcag   1320

cgactacggc acgctcttcg tggtgctggt ggtcattggg gccatctgca tcatcatcat   1380

tgcgcttggc ctgctctaca actgctggca gcgccggctg cccaagctca agcacgtgtc   1440

gcacggcgag gagctgcgct tcgtggagaa cggctgccac gacaacccca cgctggacgt   1500

ggccagcgac agccagtcgg agatgcagga gaagcacccc agcctgaacg gcggcggggc   1560

cctcaacggc ccggggagct ggggggcgct catggggggc aagcgggacc ccgaggactc   1620

ggacgtgttc gaggaggaca cgcacctgtg agcgcagccg aggcgcaggc cgagtgggcc   1680

gccaggacca agcgaggtgg accccgaaac ggacggcccg gagcccgcac cagccccgcg   1740

cctacccggg ccgcccccgc ggcctggccc tcggcgcggg ctccttcccg cttcccccga   1800

cttcacacgg cggcttcgga ccaactccct cactcccgcc cgaggggcag gcctcaaagc   1860

ccgccttggc cccgctttcc cgcccctgaa ccccggcccc gcgggcggcg ggcggcgctt   1920

cctgcgcccc gggactcaat taaacccgcc cggagaccac gccgggccca gcgcgtctgc   1980


<210>  9730
<211>  529
<212>  PRT
<213>  Homosapiens

<400>  9730

Met Gly Arg Leu Leu Arg Ala Ala Arg Leu Pro Pro Leu Leu Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Val Gly Gly Ala Phe Leu Gly Ala Cys Val Ala 
            20                  25                  30          


Gly Ser Asp Glu Pro Gly Pro Glu Gly Leu Thr Ser Thr Ser Leu Leu 
        35                  40                  45              


Asp Leu Leu Leu Pro Thr Gly Leu Glu Pro Leu Asp Ser Glu Glu Pro 
    50                  55                  60                  


Ser Glu Thr Met Gly Leu Gly Ala Gly Leu Gly Ala Pro Gly Ser Gly 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Asn Glu Glu Ser Arg Ile Leu Gln Pro Pro Gln 
                85                  90                  95      


Tyr Phe Trp Glu Glu Glu Glu Glu Leu Asn Asp Ser Ser Leu Asp Leu 
            100                 105                 110         


Gly Pro Thr Ala Asp Tyr Val Phe Pro Asp Leu Thr Glu Lys Ala Gly 
        115                 120                 125             


Ser Ile Glu Asp Thr Ser Gln Ala Gln Glu Leu Pro Asn Leu Pro Ser 
    130                 135                 140                 


Pro Leu Pro Lys Met Asn Leu Val Glu Pro Pro Trp His Met Pro Pro 
145                 150                 155                 160 


Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Arg Glu Lys Glu 
                165                 170                 175     


Glu Val Glu Lys Gln Glu Glu Glu Glu Glu Glu Glu Leu Leu Pro Val 
            180                 185                 190         


Asn Gly Ser Gln Glu Glu Ala Lys Pro Gln Val Arg Asp Phe Ser Leu 
        195                 200                 205             


Thr Ser Ser Ser Gln Thr Pro Gly Ala Thr Lys Ser Arg His Glu Asp 
    210                 215                 220                 


Ser Gly Asp Gln Ala Ser Ser Gly Val Glu Val Glu Ser Ser Met Gly 
225                 230                 235                 240 


Pro Ser Leu Leu Leu Pro Ser Val Thr Pro Thr Thr Val Thr Pro Gly 
                245                 250                 255     


Asp Gln Asp Ser Thr Ser Gln Glu Ala Glu Ala Thr Val Leu Pro Ala 
            260                 265                 270         


Ala Gly Leu Gly Val Glu Phe Glu Ala Pro Gln Glu Ala Ser Glu Glu 
        275                 280                 285             


Ala Thr Ala Gly Ala Ala Gly Leu Ser Gly Gln His Glu Glu Val Pro 
    290                 295                 300                 


Ala Leu Pro Ser Phe Pro Gln Thr Thr Ala Pro Ser Gly Ala Glu His 
305                 310                 315                 320 


Pro Asp Glu Asp Pro Leu Gly Ser Arg Thr Ser Ala Ser Ser Pro Leu 
                325                 330                 335     


Leu Leu Ala Leu Val Glu Glu Val Leu Pro Arg His Gly Ser Gly His 
            340                 345                 350         


His Gly Ala Trp His Ile Ser Leu Ser Lys Pro Ser Glu Lys Glu Gln 
        355                 360                 365             


His Leu Leu Met Thr Leu Val Gly Glu Gln Gly Val Val Pro Thr Gln 
    370                 375                 380                 


Asp Val Leu Ser Met Leu Gly Asp Ile Arg Arg Ser Leu Glu Glu Ile 
385                 390                 395                 400 


Gly Ile Gln Asn Tyr Ser Thr Thr Ser Ser Cys Gln Ala Arg Ala Ser 
                405                 410                 415     


Gln Val Arg Ser Asp Tyr Gly Thr Leu Phe Val Val Leu Val Val Ile 
            420                 425                 430         


Gly Ala Ile Cys Ile Ile Ile Ile Ala Leu Gly Leu Leu Tyr Asn Cys 
        435                 440                 445             


Trp Gln Arg Arg Leu Pro Lys Leu Lys His Val Ser His Gly Glu Glu 
    450                 455                 460                 


Leu Arg Phe Val Glu Asn Gly Cys His Asp Asn Pro Thr Leu Asp Val 
465                 470                 475                 480 


Ala Ser Asp Ser Gln Ser Glu Met Gln Glu Lys His Pro Ser Leu Asn 
                485                 490                 495     


Gly Gly Gly Ala Leu Asn Gly Pro Gly Ser Trp Gly Ala Leu Met Gly 
            500                 505                 510         


Gly Lys Arg Asp Pro Glu Asp Ser Asp Val Phe Glu Glu Asp Thr His 
        515                 520                 525             


Leu 
    


<210>  9731
<211>  2204
<212>  DNA
<213>  Homosapiens

<400>  9731
ccctgacgcg ggcccgggcg ccgcgccgct gcggctgcag gcggcgacgg ctacaccatg     60

ggccggctgc tgcgggccgc ccggctgccg ccgctgcttt cgccgctgct gcttctgctg    120

gttgggggag cgttcctggg tgcctgtgtg gctgggtctg atgagcctgg cccagagggc    180

ctcacctcca cctccctgct agacctcctg ctgcccactg gcttggagcc actggactca    240

gaggagccta gtgagaccat gggcctggga gctgggctgg gagcccctgg ctcaggcttc    300

cccagcgaag agaatgaaga gtctcggatt ctgcagccac cacagtactt ctgggaagag    360

gaggaagagc tgaatgactc aagtctggac ctgggaccca ctgcagatta tgtttttcct    420

gacttaactg agaaggcagg ttccattgaa gacaccagcc aggctcaaga gctgccaaac    480

ctcccctctc ccttgcccaa gatgaatctg gttgagcctc cctggcatat gcctcccaga    540

gaggaggaag aagaggaaga ggaagaggag gagagggaga aggaagaggt agagaaacaa    600

gaggaggagg aagaggagga gctgctccct gtgaatggat cccaagaaga agccaagcct    660

caggtccgtg acttttctct caccagcagc agccagaccc caggggccac caaaagcagg    720

catgaagact ccggggacca ggcctcatca ggtgtggagg tggagagcag catggggccc    780

agcttgctgc tgccttcagt caccccaact acagtgactc cgggggacca ggactccacc    840

agccaagagg cagaggccac agtgctgcca gctgcagggc ttggggtaga gttcgaggct    900

cctcaggaag caagcgagga agccactgca ggagcagctg gtttgtctgg ccagcacgag    960

gaggtgccgg ccttgccttc attccctcaa accacagctc ccagtggggc cgagcaccca   1020

gatgaagatc cccttggctc tagaacctca gcctcttccc cactggcccc tggagacatg   1080

gaactgacac cttcctctgc taccttggga caagaagatc tcaaccagca gctcctagaa   1140

gggcaggcag ctgaagctca atccaggata ccctgggatt ctacgcaggt gatctgcaag   1200

gactggagca atctggctgg gaaaaactac atcattctga acatgacaga gaacatagac   1260

tgtgaggtgt tccggcagca ccgggggcca cagctcctgg ccctggtgga agaggtgctg   1320

ccccgccatg gcagtggcca ccatggggcc tggcacatct ctctgagcaa gcccagcgag   1380

aaggagcagc accttctcat gacactggtg ggcgagcagg gggtggtgcc cactcaagat   1440

gtcctttcca tgctgggtga catccgcagg agcctggagg agattggcat ccagaactat   1500

tccacaacca gcagctgcca ggcgcgggcc agccaggtgc gcagcgacta cggcacgctc   1560

ttcgtggtgc tggtggtcat tggggccatc tgcatcatca tcattgcgct tggcctgctc   1620

tacaactgct ggcagcgccg gctgcccaag ctcaagcacg tgtcgcacgg cgaggagctg   1680

cgcttcgtgg agaacggctg ccacgacaac cccacgctgg acgtggccag cgacagccag   1740

tcggagatgc aggagaagca ccccagcctg aacggcggcg gggccctcaa cggcccgggg   1800

agctgggggg cgctcatggg gggcaagcgg gaccccgagg actcggacgt gttcgaggag   1860

gacacgcacc tgtgagcgca gccgaggcgc aggccgagtg ggccgccagg accaagcgag   1920

gtggaccccg aaacggacgg cccggagccc gcaccagccc cgcgcctacc cgggccgccc   1980

ccgcggcctg gccctcggcg cgggctcctt cccgcttccc ccgacttcac acggcggctt   2040

cggaccaact ccctcactcc cgcccgaggg gcaggcctca aagcccgcct tggccccgct   2100

ttcccgcccc tgaaccccgg ccccgcgggc ggcgggcggc gcttcctgcg ccccgggact   2160

caattaaacc cgcccggaga ccacgccggg cccagcgcgt ctgc                    2204


<210>  9732
<211>  605
<212>  PRT
<213>  Homosapiens

<400>  9732

Met Gly Arg Leu Leu Arg Ala Ala Arg Leu Pro Pro Leu Leu Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Val Gly Gly Ala Phe Leu Gly Ala Cys Val Ala 
            20                  25                  30          


Gly Ser Asp Glu Pro Gly Pro Glu Gly Leu Thr Ser Thr Ser Leu Leu 
        35                  40                  45              


Asp Leu Leu Leu Pro Thr Gly Leu Glu Pro Leu Asp Ser Glu Glu Pro 
    50                  55                  60                  


Ser Glu Thr Met Gly Leu Gly Ala Gly Leu Gly Ala Pro Gly Ser Gly 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Asn Glu Glu Ser Arg Ile Leu Gln Pro Pro Gln 
                85                  90                  95      


Tyr Phe Trp Glu Glu Glu Glu Glu Leu Asn Asp Ser Ser Leu Asp Leu 
            100                 105                 110         


Gly Pro Thr Ala Asp Tyr Val Phe Pro Asp Leu Thr Glu Lys Ala Gly 
        115                 120                 125             


Ser Ile Glu Asp Thr Ser Gln Ala Gln Glu Leu Pro Asn Leu Pro Ser 
    130                 135                 140                 


Pro Leu Pro Lys Met Asn Leu Val Glu Pro Pro Trp His Met Pro Pro 
145                 150                 155                 160 


Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Arg Glu Lys Glu 
                165                 170                 175     


Glu Val Glu Lys Gln Glu Glu Glu Glu Glu Glu Glu Leu Leu Pro Val 
            180                 185                 190         


Asn Gly Ser Gln Glu Glu Ala Lys Pro Gln Val Arg Asp Phe Ser Leu 
        195                 200                 205             


Thr Ser Ser Ser Gln Thr Pro Gly Ala Thr Lys Ser Arg His Glu Asp 
    210                 215                 220                 


Ser Gly Asp Gln Ala Ser Ser Gly Val Glu Val Glu Ser Ser Met Gly 
225                 230                 235                 240 


Pro Ser Leu Leu Leu Pro Ser Val Thr Pro Thr Thr Val Thr Pro Gly 
                245                 250                 255     


Asp Gln Asp Ser Thr Ser Gln Glu Ala Glu Ala Thr Val Leu Pro Ala 
            260                 265                 270         


Ala Gly Leu Gly Val Glu Phe Glu Ala Pro Gln Glu Ala Ser Glu Glu 
        275                 280                 285             


Ala Thr Ala Gly Ala Ala Gly Leu Ser Gly Gln His Glu Glu Val Pro 
    290                 295                 300                 


Ala Leu Pro Ser Phe Pro Gln Thr Thr Ala Pro Ser Gly Ala Glu His 
305                 310                 315                 320 


Pro Asp Glu Asp Pro Leu Gly Ser Arg Thr Ser Ala Ser Ser Pro Leu 
                325                 330                 335     


Ala Pro Gly Asp Met Glu Leu Thr Pro Ser Ser Ala Thr Leu Gly Gln 
            340                 345                 350         


Glu Asp Leu Asn Gln Gln Leu Leu Glu Gly Gln Ala Ala Glu Ala Gln 
        355                 360                 365             


Ser Arg Ile Pro Trp Asp Ser Thr Gln Val Ile Cys Lys Asp Trp Ser 
    370                 375                 380                 


Asn Leu Ala Gly Lys Asn Tyr Ile Ile Leu Asn Met Thr Glu Asn Ile 
385                 390                 395                 400 


Asp Cys Glu Val Phe Arg Gln His Arg Gly Pro Gln Leu Leu Ala Leu 
                405                 410                 415     


Val Glu Glu Val Leu Pro Arg His Gly Ser Gly His His Gly Ala Trp 
            420                 425                 430         


His Ile Ser Leu Ser Lys Pro Ser Glu Lys Glu Gln His Leu Leu Met 
        435                 440                 445             


Thr Leu Val Gly Glu Gln Gly Val Val Pro Thr Gln Asp Val Leu Ser 
    450                 455                 460                 


Met Leu Gly Asp Ile Arg Arg Ser Leu Glu Glu Ile Gly Ile Gln Asn 
465                 470                 475                 480 


Tyr Ser Thr Thr Ser Ser Cys Gln Ala Arg Ala Ser Gln Val Arg Ser 
                485                 490                 495     


Asp Tyr Gly Thr Leu Phe Val Val Leu Val Val Ile Gly Ala Ile Cys 
            500                 505                 510         


Ile Ile Ile Ile Ala Leu Gly Leu Leu Tyr Asn Cys Trp Gln Arg Arg 
        515                 520                 525             


Leu Pro Lys Leu Lys His Val Ser His Gly Glu Glu Leu Arg Phe Val 
    530                 535                 540                 


Glu Asn Gly Cys His Asp Asn Pro Thr Leu Asp Val Ala Ser Asp Ser 
545                 550                 555                 560 


Gln Ser Glu Met Gln Glu Lys His Pro Ser Leu Asn Gly Gly Gly Ala 
                565                 570                 575     


Leu Asn Gly Pro Gly Ser Trp Gly Ala Leu Met Gly Gly Lys Arg Asp 
            580                 585                 590         


Pro Glu Asp Ser Asp Val Phe Glu Glu Asp Thr His Leu 
        595                 600                 605 


<210>  9733
<211>  377
<212>  DNA
<213>  Homosapiens

<400>  9733
gagagcatca acatctccag agggcaccaa cagaactccc taaactgtgt acagcctcct     60

cagagatgca tcatcagtca cgctgtcggc agcatgatct gggactcagc cactaactta    120

tctgcgcacg cagtggctcc acagctatcg gcccatccta aggacatgga tacacctgat    180

gtgtgggcaa tgacccagaa ggtcaaatca ttctacagca gacacaatca caacaaggct    240

tcgctgtaca ggaaccagct ccaggtccca gcagacagct gctcggtcgg tctgctttct    300

ccaaaattga ttacggcaat gataattaaa gtagcctaat gaaggacttt gtattgaggg    360

gagcagcaga tcttgaa                                                   377


<210>  9734
<211>  81
<212>  PRT
<213>  Homosapiens

<400>  9734

Met Ile Trp Asp Ser Ala Thr Asn Leu Ser Ala His Ala Val Ala Pro 
1               5                   10                  15      


Gln Leu Ser Ala His Pro Lys Asp Met Asp Thr Pro Asp Val Trp Ala 
            20                  25                  30          


Met Thr Gln Lys Val Lys Ser Phe Tyr Ser Arg His Asn His Asn Lys 
        35                  40                  45              


Ala Ser Leu Tyr Arg Asn Gln Leu Gln Val Pro Ala Asp Ser Cys Ser 
    50                  55                  60                  


Val Gly Leu Leu Ser Pro Lys Leu Ile Thr Ala Met Ile Ile Lys Val 
65                  70                  75                  80  


Ala 
    


<210>  9735
<211>  784
<212>  DNA
<213>  Homosapiens

<400>  9735
cctggtggaa gaggtgctgc cccgccatgg cagtggccac catggggcct ggcacatctc     60

tctgagcaag cccagcgaga aggagcagca ccttctcatg acactggtgg gcgagcaggg    120

ggtggtgccc actcaagatg tcctttccat gctgggtgac atccgcagga gcctggagga    180

gattggcatc cagaactatt ccacaaccag cagctcgccg gctgcccaag ctcaagcacg    240

tgtcgcacgg cgaggagctg cgcttcgtgg agaacggctg ccacgacaac cccacgctgg    300

acgtggccag cgacagccag tcggagatgc aggagaagca ccccagcctg aacggcggcg    360

gggccctcaa cggcccgggg agctgggggg cgctcatggg gggcaagcgg gaccccgagg    420

actcggacgt gttcgaggag gacacgcacc tgtgagcgca gccgaggcgc aggccgagtg    480

ggccgccagg accaagcgag gtggaccccg aaacggacgg cccggagccc gcaccagccc    540

cgcgcctacc cgggccgccc ccgcggcctg gccctcggcg cgggctcctt cccgcttccc    600

ccgacttcac acggcggctt cggaccaact ccctcactcc cgcccgaggg gcaggcctca    660

aagcccgcct tggccccgct ttcccgcccc tgaaccccgg ccccgcgggc ggcgggcggc    720

gcttcctgcg ccccgggact caattaaacc cgcccggaga ccacgccggg cccagcgcgt    780

ctgc                                                                 784


<210>  9736
<211>  228
<212>  PRT
<213>  Homosapiens

<400>  9736

Met Thr Leu Val Gly Glu Gln Gly Val Val Pro Thr Gln Asp Val Leu 
1               5                   10                  15      


Ser Met Leu Gly Asp Ile Arg Arg Ser Leu Glu Glu Ile Gly Ile Gln 
            20                  25                  30          


Asn Tyr Ser Thr Thr Ser Ser Ser Pro Ala Ala Gln Ala Gln Ala Arg 
        35                  40                  45              


Val Ala Arg Arg Gly Ala Ala Leu Arg Gly Glu Arg Leu Pro Arg Gln 
    50                  55                  60                  


Pro His Ala Gly Arg Gly Gln Arg Gln Pro Val Gly Asp Ala Gly Glu 
65                  70                  75                  80  


Ala Pro Gln Pro Glu Arg Arg Arg Gly Pro Gln Arg Pro Gly Glu Leu 
                85                  90                  95      


Gly Gly Ala His Gly Gly Gln Ala Gly Pro Arg Gly Leu Gly Arg Val 
            100                 105                 110         


Arg Gly Gly His Ala Pro Val Ser Ala Ala Glu Ala Gln Ala Glu Trp 
        115                 120                 125             


Ala Ala Arg Thr Lys Arg Gly Gly Pro Arg Asn Gly Arg Pro Gly Ala 
    130                 135                 140                 


Arg Thr Ser Pro Ala Pro Thr Arg Ala Ala Pro Ala Ala Trp Pro Ser 
145                 150                 155                 160 


Ala Arg Ala Pro Ser Arg Phe Pro Arg Leu His Thr Ala Ala Ser Asp 
                165                 170                 175     


Gln Leu Pro His Ser Arg Pro Arg Gly Arg Pro Gln Ser Pro Pro Trp 
            180                 185                 190         


Pro Arg Phe Pro Ala Pro Glu Pro Arg Pro Arg Gly Arg Arg Ala Ala 
        195                 200                 205             


Leu Pro Ala Pro Arg Asp Ser Ile Lys Pro Ala Arg Arg Pro Arg Arg 
    210                 215                 220                 


Ala Gln Arg Val 
225             


<210>  9737
<211>  800
<212>  DNA
<213>  Homosapiens

<400>  9737
gagcccaatg caaccacccc agaggagcca tggcacccca ggacctcagc tgaggaaact     60

ggcccctccc acccctagat tggcatccag aactattcca caaccagcag ctgccaggcg    120

cgggccagcc aggtgcgcag cgactacggc acgctcttcg tggtgctggt ggtcattggg    180

gccatctgca tcatcatcat tgcgcttggc ctgctctaca actgctggca gcgccggctg    240

cccaagctca agcacgtgtc gcacggcgag gagctgcgct tcgtggagaa cggctgccac    300

gacaacccca cgctggacgt ggccagcgac agccagtcgg agatgcagga gaagcacccc    360

agcctgaacg gcggcggggc cctcaacggc ccggggagct ggggggcgct catggggggc    420

aagcgggacc ccgaggactc ggacgtgttc gaggaggaca cgcacctgtg agcgcagccg    480

aggcgcaggc cgagtgggcc gccaggacca agcgaggtgg accccgaaac ggacggcccg    540

gagcccgcac cagccccgcg cctacccggg ccgcccccgc ggcctggccc tcggcgcggg    600

ctccttcccg cttcccccga cttcacacgg cggcttcgga ccaactccct cactcccgcc    660

cgaggggcag gcctcaaagc ccgccttggc cccgctttcc cgcccctgaa ccccggcccc    720

gcgggcggcg ggcggcgctt cctgcgcccc gggactcaat taaacccgcc cggagaccac    780

gccgggccca gcgcgtctgc                                                800


<210>  9738
<211>  119
<212>  PRT
<213>  Homosapiens

<400>  9738

Met Gln Pro Pro Gln Arg Ser His Gly Thr Pro Gly Pro Gln Leu Arg 
1               5                   10                  15      


Lys Leu Ala Pro Pro Thr Pro Arg Leu Ala Ser Arg Thr Ile Pro Gln 
            20                  25                  30          


Pro Ala Ala Ala Arg Arg Gly Pro Ala Arg Cys Ala Ala Thr Thr Ala 
        35                  40                  45              


Arg Ser Ser Trp Cys Trp Trp Ser Leu Gly Pro Ser Ala Ser Ser Ser 
    50                  55                  60                  


Leu Arg Leu Ala Cys Ser Thr Thr Ala Gly Ser Ala Gly Cys Pro Ser 
65                  70                  75                  80  


Ser Ser Thr Cys Arg Thr Ala Arg Ser Cys Ala Ser Trp Arg Thr Ala 
                85                  90                  95      


Ala Thr Thr Thr Pro Arg Trp Thr Trp Pro Ala Thr Ala Ser Arg Arg 
            100                 105                 110         


Cys Arg Arg Ser Thr Pro Ala 
        115                 


<210>  9739
<211>  1986
<212>  DNA
<213>  Homosapiens

<400>  9739
ggcggggcgg ggctgagcgt gtttacatcc gccgggtgcg cggcttcgcc gcccgaggtc     60

gttcggctcg ggtaccatcc tccgcgccat ggacaccagc gacctgttcg ccagctgcag    120

gaagggggat gtgggccgag tgcgaccatg aacccgtcct gacccaggct ctgacctcct    180

tcctgcccag gtacctgctg gagcagcgag acgtggaggt actatgcctg cttgtgtggg    240

cacgaggagc tggtactcta ccttctggcc aatggagccc gctgcgaggc caacaccttc    300

gatggtgagc gctgcctcta tggggcactg agtgacccca tccgccgggc tctacgcgat    360

tacaagcagg tcacggcttc ctgcaggagg cgggattact atgacgactt cttgcagcgg    420

cttctagagc agggcatcca cagtgacgtg gtctttgtag tacacgggaa gccattccgg    480

gtgcatcgct gcgtcctggg tgcacgtagt gcctactttg ccaacatgct ggacaccaaa    540

tggaagggca agagtgtcgt ggttctcagg cacccactga tcaaccccgt ggcctttggg    600

gccctgctgc agtacctgta cacaggccgc ctggacattg gcgtagagca tgtgagtgac    660

tgtgagcgcc tggccaagca atgccagctg tgggacctgc tcagcgacct ggaggccaag    720

tgcgagaagg tgtctgagtt tgtggcgtct aagccaggca cgtgtgtgaa ggtgctgacc    780

atcgagcccc cacctgcaga cccccgcctc cgggaggaca tggcgctgct ggccgattgt    840

gccctgcccc ccgagctccg aggtgatctt tgggagctgc ccttcccttg tcctgacggc    900

ttcaacagct gccctgacat ctgcttccga gtggctggct gcagcttcct ctgccacaag    960

gcctttttct gtggccgcag tgactacttc cgagccctgc tggatgacca cttccgagag   1020

agcgaggagc cagcgacctc agggggcccc ccagccgtca ccctgcatgg catctcaccc   1080

gacgtcttca ctcacgtgct ctactacatg tacagcgacc acactgagct gtcccccgag   1140

gcagcctatg atgtgctgag cgtcgccgac atgtacctgc tgccaggcct gaagaggctg   1200

tgcggccgca gcctggctca gatgctagac gaggacactg tggtgggtgt gtggcgcgtg   1260

gccaagctct tccgcctggc gcggcttgag gaccagtgca ctgagtacat ggccaaggtc   1320

attgagaagc tggtggagcg ggaggacttc gtggaggcgg tgaaggagga ggcagcggct   1380

gtggcagccc ggcaggagac ggactctatc ccgctggtgg acgacatccg cttccacgtg   1440

gccagcacgg tgcagaccta cagcgccata gaggaggcgc agcagcgtct gcgggcactc   1500

gaggacctgc tcgtgtccat cggtctggac tgttgagccc ctggctgggc agccccaggg   1560

gccaggagct ctcttggaga caagcatgtg tatgcgtttg tgtgcagctc ttcttcctgc   1620

tccctgcaca ttgagggctt catggggggt gcgaggggct cagtggggct tctcttccct   1680

ccatgagcct ggagacccca ggggaggatc catttgggat gagccccctc cccccaatgc   1740

acaagccagc ccccaagacc ctgggggtgg acaccactca gggaaacctg gggtgggggt   1800

gggctttggt cttagcactt tccttctcca gatcccccct acccacccca gtcccaaatc   1860

cagtcctctg gcccttgcct agccctgaat tgcttctcta agctggtgtt cccatgcaca   1920

gggccattca ggaagggctg ggggagtgtg tgtggcaata aagcttgaag gcaccgtggg   1980

agcatg                                                              1986


<210>  9740
<211>  336
<212>  PRT
<213>  Homosapiens

<400>  9740

Met Leu Asp Thr Lys Trp Lys Gly Lys Ser Val Val Val Leu Arg His 
1               5                   10                  15      


Pro Leu Ile Asn Pro Val Ala Phe Gly Ala Leu Leu Gln Tyr Leu Tyr 
            20                  25                  30          


Thr Gly Arg Leu Asp Ile Gly Val Glu His Val Ser Asp Cys Glu Arg 
        35                  40                  45              


Leu Ala Lys Gln Cys Gln Leu Trp Asp Leu Leu Ser Asp Leu Glu Ala 
    50                  55                  60                  


Lys Cys Glu Lys Val Ser Glu Phe Val Ala Ser Lys Pro Gly Thr Cys 
65                  70                  75                  80  


Val Lys Val Leu Thr Ile Glu Pro Pro Pro Ala Asp Pro Arg Leu Arg 
                85                  90                  95      


Glu Asp Met Ala Leu Leu Ala Asp Cys Ala Leu Pro Pro Glu Leu Arg 
            100                 105                 110         


Gly Asp Leu Trp Glu Leu Pro Phe Pro Cys Pro Asp Gly Phe Asn Ser 
        115                 120                 125             


Cys Pro Asp Ile Cys Phe Arg Val Ala Gly Cys Ser Phe Leu Cys His 
    130                 135                 140                 


Lys Ala Phe Phe Cys Gly Arg Ser Asp Tyr Phe Arg Ala Leu Leu Asp 
145                 150                 155                 160 


Asp His Phe Arg Glu Ser Glu Glu Pro Ala Thr Ser Gly Gly Pro Pro 
                165                 170                 175     


Ala Val Thr Leu His Gly Ile Ser Pro Asp Val Phe Thr His Val Leu 
            180                 185                 190         


Tyr Tyr Met Tyr Ser Asp His Thr Glu Leu Ser Pro Glu Ala Ala Tyr 
        195                 200                 205             


Asp Val Leu Ser Val Ala Asp Met Tyr Leu Leu Pro Gly Leu Lys Arg 
    210                 215                 220                 


Leu Cys Gly Arg Ser Leu Ala Gln Met Leu Asp Glu Asp Thr Val Val 
225                 230                 235                 240 


Gly Val Trp Arg Val Ala Lys Leu Phe Arg Leu Ala Arg Leu Glu Asp 
                245                 250                 255     


Gln Cys Thr Glu Tyr Met Ala Lys Val Ile Glu Lys Leu Val Glu Arg 
            260                 265                 270         


Glu Asp Phe Val Glu Ala Val Lys Glu Glu Ala Ala Ala Val Ala Ala 
        275                 280                 285             


Arg Gln Glu Thr Asp Ser Ile Pro Leu Val Asp Asp Ile Arg Phe His 
    290                 295                 300                 


Val Ala Ser Thr Val Gln Thr Tyr Ser Ala Ile Glu Glu Ala Gln Gln 
305                 310                 315                 320 


Arg Leu Arg Ala Leu Glu Asp Leu Leu Val Ser Ile Gly Leu Asp Cys 
                325                 330                 335     


<210>  9741
<211>  1975
<212>  DNA
<213>  Homosapiens

<400>  9741
ggcggggcgg ggctgagcgt gtttacatcc gccgggtgcg cggcttcgcc gcccgaggtc     60

gttcggctcg ggtaccatcc tccgcgccat ggacaccagc gacctgttcg ccagctgcag    120

gaagggggat gtgggccgag tgcggtacct gctggagcag cgagacgtgg aggtgaatgt    180

gcgggacaag tgggacagca cccccttgta ctatgcctgc ttgtgtgggc acgaggagct    240

ggtactctac cttctggcca atggagcccg ctgcgaggcc aacaccttcg atggtgagcg    300

ctgcctctat ggggcactga gtgaccccat ccgccgggct ctacgcgatt acaagcaggt    360

cacggcttcc tgcaggaggc gggattacta tgacgacttc ttgcagcggc ttctagagca    420

gggcatccac agtgacgtgg tctttgtagt acacgggaag ccattccggg tgcatcgctg    480

cgtcctgggt gcacgtagtg cctactttgc caacatgctg gacaccaaat ggaagggcaa    540

gagtgtcgtg gttctcaggc acccactgat caaccccgtg gcctttgggg ccctgctgca    600

gtacctgtac acaggccgcc tggacattgg cgtagagcat gtgagtgact gtgagcgcct    660

ggccaagcaa tgccagctgt gggacctgct cagcgacctg gaggccaagt gcgagaaggt    720

gtctgagttt gtggcgtcta agccaggcac gtgtgtgaag gtgctgacca tcgagccccc    780

acctgcagac ccccgcctcc gggaggacat ggcgctgctg gccgattgtg ccctgccccc    840

cgagctccga ggtgatcttt gggagctgcc cttcccttgt cctgacggct tcaacagctg    900

ccctgacatc tgcttccgag tggctggctg cagcttcctc tgccacaagg cctttttctg    960

tggccgcagt gactacttcc gagccctgct ggatgaccac ttccgagaga gcgaggagcc   1020

agcgacctca gggggccccc cagccgtcac cctgcatggc atctcacccg acgtcttcac   1080

tcacgtgctc tactacatgt acagcgacca cactgagctg tcccccgagg cagcctatga   1140

tgtgctgagc gtcgccgaca tgtacctgct gccaggcctg aagaggctgt gcggccgcag   1200

cctggctcag atgctagacg aggacactgt ggtgggtgtg tggcgcgtgg ccaagctctt   1260

ccgcctggcg cggcttgagg accagtgcac tgagtacatg gccaaggtca ttgagaagct   1320

ggtggagcgg gaggacttcg tggaggcggt gaaggaggag gcagcggctg tggcagcccg   1380

gcaggagacg gactctatcc cgctggtgga cgacatccgc ttccacgtgg ccagcacggt   1440

gcagacctac agcgccatag aggaggcgca gcagcgtctg cgggcactcg aggacctgct   1500

cgtgtccatc ggtctggact gttgagcccc tggctgggca gccccagggg ccaggagctc   1560

tcttggagac aagcatgtgt atgcgtttgt gtgcagctct tcttcctgct ccctgcacat   1620

tgagggcttc atggggggtg cgaggggctc agtggggctt ctcttccctc catgagcctg   1680

gagaccccag gggaggatcc atttgggatg agccccctcc ccccaatgca caagccagcc   1740

cccaagaccc tgggggtgga caccactcag ggaaacctgg ggtgggggtg ggctttggtc   1800

ttagcacttt ccttctccag atccccccta cccaccccag tcccaaatcc agtcctctgg   1860

cccttgccta gccctgaatt gcttctctaa gctggtgttc ccatgcacag ggccattcag   1920

gaagggctgg gggagtgtgt gtggcaataa agcttgaagg caccgtggga gcatg        1975


<210>  9742
<211>  478
<212>  PRT
<213>  Homosapiens

<400>  9742

Met Asp Thr Ser Asp Leu Phe Ala Ser Cys Arg Lys Gly Asp Val Gly 
1               5                   10                  15      


Arg Val Arg Tyr Leu Leu Glu Gln Arg Asp Val Glu Val Asn Val Arg 
            20                  25                  30          


Asp Lys Trp Asp Ser Thr Pro Leu Tyr Tyr Ala Cys Leu Cys Gly His 
        35                  40                  45              


Glu Glu Leu Val Leu Tyr Leu Leu Ala Asn Gly Ala Arg Cys Glu Ala 
    50                  55                  60                  


Asn Thr Phe Asp Gly Glu Arg Cys Leu Tyr Gly Ala Leu Ser Asp Pro 
65                  70                  75                  80  


Ile Arg Arg Ala Leu Arg Asp Tyr Lys Gln Val Thr Ala Ser Cys Arg 
                85                  90                  95      


Arg Arg Asp Tyr Tyr Asp Asp Phe Leu Gln Arg Leu Leu Glu Gln Gly 
            100                 105                 110         


Ile His Ser Asp Val Val Phe Val Val His Gly Lys Pro Phe Arg Val 
        115                 120                 125             


His Arg Cys Val Leu Gly Ala Arg Ser Ala Tyr Phe Ala Asn Met Leu 
    130                 135                 140                 


Asp Thr Lys Trp Lys Gly Lys Ser Val Val Val Leu Arg His Pro Leu 
145                 150                 155                 160 


Ile Asn Pro Val Ala Phe Gly Ala Leu Leu Gln Tyr Leu Tyr Thr Gly 
                165                 170                 175     


Arg Leu Asp Ile Gly Val Glu His Val Ser Asp Cys Glu Arg Leu Ala 
            180                 185                 190         


Lys Gln Cys Gln Leu Trp Asp Leu Leu Ser Asp Leu Glu Ala Lys Cys 
        195                 200                 205             


Glu Lys Val Ser Glu Phe Val Ala Ser Lys Pro Gly Thr Cys Val Lys 
    210                 215                 220                 


Val Leu Thr Ile Glu Pro Pro Pro Ala Asp Pro Arg Leu Arg Glu Asp 
225                 230                 235                 240 


Met Ala Leu Leu Ala Asp Cys Ala Leu Pro Pro Glu Leu Arg Gly Asp 
                245                 250                 255     


Leu Trp Glu Leu Pro Phe Pro Cys Pro Asp Gly Phe Asn Ser Cys Pro 
            260                 265                 270         


Asp Ile Cys Phe Arg Val Ala Gly Cys Ser Phe Leu Cys His Lys Ala 
        275                 280                 285             


Phe Phe Cys Gly Arg Ser Asp Tyr Phe Arg Ala Leu Leu Asp Asp His 
    290                 295                 300                 


Phe Arg Glu Ser Glu Glu Pro Ala Thr Ser Gly Gly Pro Pro Ala Val 
305                 310                 315                 320 


Thr Leu His Gly Ile Ser Pro Asp Val Phe Thr His Val Leu Tyr Tyr 
                325                 330                 335     


Met Tyr Ser Asp His Thr Glu Leu Ser Pro Glu Ala Ala Tyr Asp Val 
            340                 345                 350         


Leu Ser Val Ala Asp Met Tyr Leu Leu Pro Gly Leu Lys Arg Leu Cys 
        355                 360                 365             


Gly Arg Ser Leu Ala Gln Met Leu Asp Glu Asp Thr Val Val Gly Val 
    370                 375                 380                 


Trp Arg Val Ala Lys Leu Phe Arg Leu Ala Arg Leu Glu Asp Gln Cys 
385                 390                 395                 400 


Thr Glu Tyr Met Ala Lys Val Ile Glu Lys Leu Val Glu Arg Glu Asp 
                405                 410                 415     


Phe Val Glu Ala Val Lys Glu Glu Ala Ala Ala Val Ala Ala Arg Gln 
            420                 425                 430         


Glu Thr Asp Ser Ile Pro Leu Val Asp Asp Ile Arg Phe His Val Ala 
        435                 440                 445             


Ser Thr Val Gln Thr Tyr Ser Ala Ile Glu Glu Ala Gln Gln Arg Leu 
    450                 455                 460                 


Arg Ala Leu Glu Asp Leu Leu Val Ser Ile Gly Leu Asp Cys 
465                 470                 475             


<210>  9743
<211>  1940
<212>  DNA
<213>  Homosapiens

<400>  9743
ggcggggcgg ggctgagcgt gtttacatcc gccgggtgcg cggcttcgcc gcccgaggtc     60

gttcggctcg ggtaccatcc tccgcgccat ggacaccagc gacctgttcg ccagctgcag    120

gaagggggat gtgggccgag tgcggtacct gctggagcag cgagacgtgg aggtactatg    180

cctgcttgtg tgggcacgag gagctggtac tctaccttct ggccaatgga gcccgctgcg    240

aggccaacac cttcgatggt gagcgctgcc tctatggggc actgagtgac cccatccgcc    300

gggctctacg cgattacaag caggtcacgg cttcctgcag gaggcgggat tactatgacg    360

acttcttgca gcggcttcta gagcagggca tccacagtga cgtggtcttt gtagtacacg    420

ggaagccatt ccgggtgcat cgctgcgtcc tgggtgcacg tagtgcctac tttgccaaca    480

tgctggacac caaatggaag ggcaagagtg tcgtggttct caggcaccca ctgatcaacc    540

ccgtggcctt tggggccctg ctgcagtacc tgtacacagg ccgcctggac attggcgtag    600

agcatgtgag tgactgtgag cgcctggcca agcaatgcca gctgtgggac ctgctcagcg    660

acctggaggc caagtgcgag aaggtgtctg agtttgtggc gtctaagcca ggcacgtgtg    720

tgaaggtgct gaccatcgag cccccacctg cagacccccg cctccgggag gacatggcgc    780

tgctggccga ttgtgccctg ccccccgagc tccgaggtga tctttgggag ctgcccttcc    840

cttgtcctga cggcttcaac agctgccctg acatctgctt ccgagtggct ggctgcagct    900

tcctctgcca caaggccttt ttctgtggcc gcagtgacta cttccgagcc ctgctggatg    960

accacttccg agagagcgag gagccagcga cctcaggggg ccccccagcc gtcaccctgc   1020

atggcatctc acccgacgtc ttcactcacg tgctctacta catgtacagc gaccacactg   1080

agctgtcccc cgaggcagcc tatgatgtgc tgagcgtcgc cgacatgtac ctgctgccag   1140

gcctgaagag gctgtgcggc cgcagcctgg ctcagatgct agacgaggac actgtggtgg   1200

gtgtgtggcg cgtggccaag ctcttccgcc tggcgcggct tgaggaccag tgcactgagt   1260

acatggccaa ggtcattgag aagctggtgg agcgggagga cttcgtggag gcggtgaagg   1320

aggaggcagc ggctgtggca gcccggcagg agacggactc tatcccgctg gtggacgaca   1380

tccgcttcca cgtggccagc acggtgcaga cctacagcgc catagaggag gcgcagcagc   1440

gtctgcgggc actcgaggac ctgctcgtgt ccatcggtct ggactgttga gcccctggct   1500

gggcagcccc aggggccagg agctctcttg gagacaagca tgtgtatgcg tttgtgtgca   1560

gctcttcttc ctgctccctg cacattgagg gcttcatggg gggtgcgagg ggctcagtgg   1620

ggcttctctt ccctccatga gcctggagac cccaggggag gatccatttg ggatgagccc   1680

cctcccccca atgcacaagc cagcccccaa gaccctgggg gtggacacca ctcagggaaa   1740

cctggggtgg gggtgggctt tggtcttagc actttccttc tccagatccc ccctacccac   1800

cccagtccca aatccagtcc tctggccctt gcctagccct gaattgcttc tctaagctgg   1860

tgttcccatg cacagggcca ttcaggaagg gctgggggag tgtgtgtggc aataaagctt   1920

gaaggcaccg tgggagcatg                                               1940


<210>  9744
<211>  453
<212>  PRT
<213>  Homosapiens

<400>  9744

Met Trp Ala Glu Cys Gly Thr Cys Trp Ser Ser Glu Thr Trp Arg Tyr 
1               5                   10                  15      


Tyr Ala Cys Leu Cys Gly His Glu Glu Leu Val Leu Tyr Leu Leu Ala 
            20                  25                  30          


Asn Gly Ala Arg Cys Glu Ala Asn Thr Phe Asp Gly Glu Arg Cys Leu 
        35                  40                  45              


Tyr Gly Ala Leu Ser Asp Pro Ile Arg Arg Ala Leu Arg Asp Tyr Lys 
    50                  55                  60                  


Gln Val Thr Ala Ser Cys Arg Arg Arg Asp Tyr Tyr Asp Asp Phe Leu 
65                  70                  75                  80  


Gln Arg Leu Leu Glu Gln Gly Ile His Ser Asp Val Val Phe Val Val 
                85                  90                  95      


His Gly Lys Pro Phe Arg Val His Arg Cys Val Leu Gly Ala Arg Ser 
            100                 105                 110         


Ala Tyr Phe Ala Asn Met Leu Asp Thr Lys Trp Lys Gly Lys Ser Val 
        115                 120                 125             


Val Val Leu Arg His Pro Leu Ile Asn Pro Val Ala Phe Gly Ala Leu 
    130                 135                 140                 


Leu Gln Tyr Leu Tyr Thr Gly Arg Leu Asp Ile Gly Val Glu His Val 
145                 150                 155                 160 


Ser Asp Cys Glu Arg Leu Ala Lys Gln Cys Gln Leu Trp Asp Leu Leu 
                165                 170                 175     


Ser Asp Leu Glu Ala Lys Cys Glu Lys Val Ser Glu Phe Val Ala Ser 
            180                 185                 190         


Lys Pro Gly Thr Cys Val Lys Val Leu Thr Ile Glu Pro Pro Pro Ala 
        195                 200                 205             


Asp Pro Arg Leu Arg Glu Asp Met Ala Leu Leu Ala Asp Cys Ala Leu 
    210                 215                 220                 


Pro Pro Glu Leu Arg Gly Asp Leu Trp Glu Leu Pro Phe Pro Cys Pro 
225                 230                 235                 240 


Asp Gly Phe Asn Ser Cys Pro Asp Ile Cys Phe Arg Val Ala Gly Cys 
                245                 250                 255     


Ser Phe Leu Cys His Lys Ala Phe Phe Cys Gly Arg Ser Asp Tyr Phe 
            260                 265                 270         


Arg Ala Leu Leu Asp Asp His Phe Arg Glu Ser Glu Glu Pro Ala Thr 
        275                 280                 285             


Ser Gly Gly Pro Pro Ala Val Thr Leu His Gly Ile Ser Pro Asp Val 
    290                 295                 300                 


Phe Thr His Val Leu Tyr Tyr Met Tyr Ser Asp His Thr Glu Leu Ser 
305                 310                 315                 320 


Pro Glu Ala Ala Tyr Asp Val Leu Ser Val Ala Asp Met Tyr Leu Leu 
                325                 330                 335     


Pro Gly Leu Lys Arg Leu Cys Gly Arg Ser Leu Ala Gln Met Leu Asp 
            340                 345                 350         


Glu Asp Thr Val Val Gly Val Trp Arg Val Ala Lys Leu Phe Arg Leu 
        355                 360                 365             


Ala Arg Leu Glu Asp Gln Cys Thr Glu Tyr Met Ala Lys Val Ile Glu 
    370                 375                 380                 


Lys Leu Val Glu Arg Glu Asp Phe Val Glu Ala Val Lys Glu Glu Ala 
385                 390                 395                 400 


Ala Ala Val Ala Ala Arg Gln Glu Thr Asp Ser Ile Pro Leu Val Asp 
                405                 410                 415     


Asp Ile Arg Phe His Val Ala Ser Thr Val Gln Thr Tyr Ser Ala Ile 
            420                 425                 430         


Glu Glu Ala Gln Gln Arg Leu Arg Ala Leu Glu Asp Leu Leu Val Ser 
        435                 440                 445             


Ile Gly Leu Asp Cys 
    450             


<210>  9745
<211>  919
<212>  DNA
<213>  Homosapiens

<400>  9745
cggggcgggg ctgagcgtgt ttacatccgc cgggtgcgcg gcttcgccgc ccgaggtcgt     60

tcggctcggg taccatcctc cgcgccatgg acaccagcga cctgttcgcc agctgcagga    120

agggggatgt gggccgagtg cggtacctgc tggagcagcg agacgtggag gtactatgcc    180

tgcttgtgtg ggcacgagga gctggtactc taccttctgg ccaatggagc ccgctgcgag    240

gccaacacct tcgatggtga gcgctgcctc tatggggcac tgagtgaccc catccgccgg    300

gctctacgcg attacaagca ggtcacggct tcctgcagga ggcgggatta ctatgacgac    360

ttcttgcagc ggcttctaga gcagggcatc cacagtgacg tggtctttgt agtacacggg    420

aagccattcc gggtgcatcg ctgcgtcctg ggtgcacgta gtgcctactt tgccaacatg    480

ctggacacca aatggaaggg caagagtgtc gtggttctca ggcacccact gatcaacccc    540

gtggcctttg gggccctgct gcagtacctg tacacaggtg accccctggg tccagggtag    600

gaggagaggg agtgggccgt ccttctggac agcagtacac ctaggtgtgg ctgggctgac    660

ctttcacctc tagacacttc atggtccccc cggggtggtt ccagctgcct ctcgggttgg    720

gttgcaagag agaggactag tgtgcctgct caggaagagc ttgtcccacc cacatgctga    780

ggccctccca tctgttccct ggggcctgta gaacagcttt tgatggggaa accatggtgg    840

caagtgggcc caggagtcct agtcctgcag ccaggtggcc aggtgggagg ggatcaccct    900

ttttctgtgg gcctgatga                                                 919


<210>  9746
<211>  157
<212>  PRT
<213>  Homosapiens

<400>  9746

Met Trp Ala Glu Cys Gly Thr Cys Trp Ser Ser Glu Thr Trp Arg Tyr 
1               5                   10                  15      


Tyr Ala Cys Leu Cys Gly His Glu Glu Leu Val Leu Tyr Leu Leu Ala 
            20                  25                  30          


Asn Gly Ala Arg Cys Glu Ala Asn Thr Phe Asp Gly Glu Arg Cys Leu 
        35                  40                  45              


Tyr Gly Ala Leu Ser Asp Pro Ile Arg Arg Ala Leu Arg Asp Tyr Lys 
    50                  55                  60                  


Gln Val Thr Ala Ser Cys Arg Arg Arg Asp Tyr Tyr Asp Asp Phe Leu 
65                  70                  75                  80  


Gln Arg Leu Leu Glu Gln Gly Ile His Ser Asp Val Val Phe Val Val 
                85                  90                  95      


His Gly Lys Pro Phe Arg Val His Arg Cys Val Leu Gly Ala Arg Ser 
            100                 105                 110         


Ala Tyr Phe Ala Asn Met Leu Asp Thr Lys Trp Lys Gly Lys Ser Val 
        115                 120                 125             


Val Val Leu Arg His Pro Leu Ile Asn Pro Val Ala Phe Gly Ala Leu 
    130                 135                 140                 


Leu Gln Tyr Leu Tyr Thr Gly Asp Pro Leu Gly Pro Gly 
145                 150                 155         


<210>  9747
<211>  685
<212>  DNA
<213>  Homosapiens

<400>  9747
gagcgtgttt acatccgccg ggtgcgcggc ttcgccgccc gaggtcgttc ggctcgggta     60

ccatcctccg cgccatggac accagcgacc tgttcgccag ctgcaggaag ggggatgtgg    120

gccgagtgcg gtacctgctg gagcagcgag acgtggaggt gaatgtgcgg gacaagtggg    180

acagcacccc cttgtactat gcctgcttgt gtgggcacga ggagctggta ctctaccttc    240

tggccaatgg agcccgctgc gaggccaaca ccttcgatgg tgagcgctgc ctctatgggg    300

cactgagtga ccccatccgc cgggctctac gcgattacaa gcaggtcacg gcttcctgca    360

ggaggcggga ttactatgac gacttcttgc agcggtgagc cagggcacac gaggggtgca    420

gcatggggtg cggtggccct ggtgggtgtg gcgagtctgc tctgactgtg gcctgcactg    480

ggttctgagt gctccgagga atggggtggg gctgtgccaa gtatcctccc tcctggcttg    540

tccctcccca ggcttctaga gcagggcatc cacagtgacg tggtctttgt agtacacggg    600

aagccattcc gggtgcatcg ctgcgtcctg ggtgcacgta gtgcctactt tgccaacatg    660

ctggacacca aatggaaggg caaga                                          685


<210>  9748
<211>  107
<212>  PRT
<213>  Homosapiens

<400>  9748

Met Asp Thr Ser Asp Leu Phe Ala Ser Cys Arg Lys Gly Asp Val Gly 
1               5                   10                  15      


Arg Val Arg Tyr Leu Leu Glu Gln Arg Asp Val Glu Val Asn Val Arg 
            20                  25                  30          


Asp Lys Trp Asp Ser Thr Pro Leu Tyr Tyr Ala Cys Leu Cys Gly His 
        35                  40                  45              


Glu Glu Leu Val Leu Tyr Leu Leu Ala Asn Gly Ala Arg Cys Glu Ala 
    50                  55                  60                  


Asn Thr Phe Asp Gly Glu Arg Cys Leu Tyr Gly Ala Leu Ser Asp Pro 
65                  70                  75                  80  


Ile Arg Arg Ala Leu Arg Asp Tyr Lys Gln Val Thr Ala Ser Cys Arg 
                85                  90                  95      


Arg Arg Asp Tyr Tyr Asp Asp Phe Leu Gln Arg 
            100                 105         


<210>  9749
<211>  997
<212>  DNA
<213>  Homosapiens

<400>  9749
agcgtgttta catccgccgg gtgcgcggct tcgccgcccg aggtcgttcg gctcgggtac     60

catcctccgc gccatggaca ccagcgacct gttcgccagc tgcaggaagg gggatgtggg    120

ccgagtgcga ccatgaaccc gtcctgaccc aggctctgac ctccttcctg cccaggtacc    180

tgctggagca gcgagacgtg gaggtactat gcctgcttgt gtgggcacga ggagctggta    240

ctctaccttc tggccaatgg agcccgctgc gaggccaaca ccttcgatgg tgagcgctgc    300

ctctatgggg cactgagtga ccccatccgc cgggctctac gcgattacaa gcaggtcacg    360

gcttcctgca ggaggcggga ttactatgac gacttcttgc agcggcttct agagcagggc    420

atccacagtg acgtggtctt tgtagtacac gggaagccat tccgggtgca tcgctgcgtc    480

ctgggtgcac gtagtgccta ctttgccaac atgctggaca ccaaatggaa gggcaagagt    540

gtcgtggttc tcaggcaccc actgatcaac cccgtggcct ttggggccct gctgcagtac    600

ctgtacacag gtgaccccct gggtccaggg taggaggaga gggagtgggc cgtccttctg    660

gacagcagta cacctaggtg tggctgggct gacctttcac ctctagacac ttcatggtcc    720

ccccggggtg gttccagctg cctctcgggt tgggttgcaa gagagaggac tagtgtgcct    780

gctcaggaag agcttgtccc acccacatgc tgaggccctc ccatctgttc cctggggcct    840

gtagaacagc ttttgatggg gaaaccatgg tggcaagtgg gcccaggagt cctagtcctg    900

cagccaggtg gccaggtggg aggggatcac cctttttctg tgggcctgat gacagctgag    960

gtcccgcagg ccctcatcct ccccactgcc cccaggc                             997


<210>  9750
<211>  59
<212>  PRT
<213>  Homosapiens

<400>  9750

Met Trp Ala Glu Cys Asp His Glu Pro Val Leu Thr Gln Ala Leu Thr 
1               5                   10                  15      


Ser Phe Leu Pro Arg Tyr Leu Leu Glu Gln Arg Asp Val Glu Val Leu 
            20                  25                  30          


Cys Leu Leu Val Trp Ala Arg Gly Ala Gly Thr Leu Pro Ser Gly Gln 
        35                  40                  45              


Trp Ser Pro Leu Arg Gly Gln His Leu Arg Trp 
    50                  55                  


<210>  9751
<211>  1385
<212>  DNA
<213>  Homosapiens

<400>  9751
gtgtttacat ccgccgggtg cgcggcttcg ccgcccgagg tcgttcggct cgggtaccat     60

cctccgcgcc atggacacca gcgacctgtt cgccagctgc aggaaggggg atgtgggccg    120

agtgcggtga ggacgagctg gtactctacc ttctggccaa tggagcccgc tgcgaggcca    180

acaccttcga tggtgagcgc tgcctctatg gggcactgag tgaccccatc cgccgggctc    240

tacgcgatta caagcagctg tgggacctgc tcagcgacct ggaggccaag tgcgagaagg    300

tgtctgagtt tgtggcgtct aagccaggca cgtgtgtgaa ggtgctgacc atcgagcccc    360

cacctgcaga cccccgcctc cgggaggaca tggcgctgct ggccgattgt gccctgcccc    420

ccgagctccg agcctttttc tgtggccgca gtgactactt ccgagccctg ctggatgacc    480

acttccgaga gagcgaggag ccagcgacct cagggggccc cccagccgtc accctgcatg    540

gcatctcacc cgacgtcttc actcacgtgc tctactacat gtacagcgac cacactgagc    600

tgtcccccga ggcagcctat gatgtgctga gcgtcgccga catgtacctg ctgccaggcc    660

tgaagaggct gtgcggccgc agcctggctc agatgctaga cgaggacact gtggtgggtg    720

tgtggcgcgt ggccaagctc ttccgcctgg cgcggcttga ggaccagtgc actgagtaca    780

tggccaaggt cattgagaag ctggtggagc gggaggactt cgtggaggcg gtgaaggagg    840

aggcagcggc tgtggcagcc cggcaggaga cggactctat cccgctggtg gacgacatcc    900

gcttccacgt ggccagcacg gtgcagacct acagcgccat agaggaggcg cagcagcgtc    960

tgcggagctc tcttggagac aagcatgtgt atgcgtttgt gtgcagctct tcttcctgct   1020

ccctgcacat tgagggcttc atggggggtg cgaggggctc agtggggctt ctcttccctc   1080

catgagcctg gagaccccag gggaggatcc atttgggatg agccccctcc ccccaatgca   1140

caagccagcc cccaagaccc tgggggtgga caccactcag ggaaacctgg ggtgggggtg   1200

ggctttggtc ttagcacttt ccttctccag atccccccta cccaccccag tcccaaatcc   1260

agtcctctgg cccttgccta gccctgaatt gcttctctaa gctggtgttc ccatgcacag   1320

ggccattcag gaagggctgg gggagtgtgt gtggcaataa agcttgaagg caccgtggga   1380

gcatg                                                               1385


<210>  9752
<211>  324
<212>  PRT
<213>  Homosapiens

<400>  9752

Met Trp Ala Glu Cys Gly Glu Asp Glu Leu Val Leu Tyr Leu Leu Ala 
1               5                   10                  15      


Asn Gly Ala Arg Cys Glu Ala Asn Thr Phe Asp Gly Glu Arg Cys Leu 
            20                  25                  30          


Tyr Gly Ala Leu Ser Asp Pro Ile Arg Arg Ala Leu Arg Asp Tyr Lys 
        35                  40                  45              


Gln Leu Trp Asp Leu Leu Ser Asp Leu Glu Ala Lys Cys Glu Lys Val 
    50                  55                  60                  


Ser Glu Phe Val Ala Ser Lys Pro Gly Thr Cys Val Lys Val Leu Thr 
65                  70                  75                  80  


Ile Glu Pro Pro Pro Ala Asp Pro Arg Leu Arg Glu Asp Met Ala Leu 
                85                  90                  95      


Leu Ala Asp Cys Ala Leu Pro Pro Glu Leu Arg Ala Phe Phe Cys Gly 
            100                 105                 110         


Arg Ser Asp Tyr Phe Arg Ala Leu Leu Asp Asp His Phe Arg Glu Ser 
        115                 120                 125             


Glu Glu Pro Ala Thr Ser Gly Gly Pro Pro Ala Val Thr Leu His Gly 
    130                 135                 140                 


Ile Ser Pro Asp Val Phe Thr His Val Leu Tyr Tyr Met Tyr Ser Asp 
145                 150                 155                 160 


His Thr Glu Leu Ser Pro Glu Ala Ala Tyr Asp Val Leu Ser Val Ala 
                165                 170                 175     


Asp Met Tyr Leu Leu Pro Gly Leu Lys Arg Leu Cys Gly Arg Ser Leu 
            180                 185                 190         


Ala Gln Met Leu Asp Glu Asp Thr Val Val Gly Val Trp Arg Val Ala 
        195                 200                 205             


Lys Leu Phe Arg Leu Ala Arg Leu Glu Asp Gln Cys Thr Glu Tyr Met 
    210                 215                 220                 


Ala Lys Val Ile Glu Lys Leu Val Glu Arg Glu Asp Phe Val Glu Ala 
225                 230                 235                 240 


Val Lys Glu Glu Ala Ala Ala Val Ala Ala Arg Gln Glu Thr Asp Ser 
                245                 250                 255     


Ile Pro Leu Val Asp Asp Ile Arg Phe His Val Ala Ser Thr Val Gln 
            260                 265                 270         


Thr Tyr Ser Ala Ile Glu Glu Ala Gln Gln Arg Leu Arg Ser Ser Leu 
        275                 280                 285             


Gly Asp Lys His Val Tyr Ala Phe Val Cys Ser Ser Ser Ser Cys Ser 
    290                 295                 300                 


Leu His Ile Glu Gly Phe Met Gly Gly Ala Arg Gly Ser Val Gly Leu 
305                 310                 315                 320 


Leu Phe Pro Pro 
                


<210>  9753
<211>  1107
<212>  DNA
<213>  Homosapiens

<400>  9753
gtgtttacat ccgccgggtg cgcggcttcg ccgcccgagg tcgttcggct cgggtaccat     60

cctccgcgcc atggacacca gcgacctgtt cgccagctgc aggaaggggg atgtgggccg    120

agtgcggtac ctgctggagc agccgaggag ccagcgacct cagggggccc cccagccgtc    180

accctgcatg gcatctcacc cgacgtcttc actcacgtgc tctactacat gtacagcgac    240

cacactgagc tgtcccccga ggcagcctat gatgtgctga gcgtcgccga catgtacctg    300

ctgccaggcc tgaagaggct gtgcggccgc agcctggctc agatgctaga cgaggacact    360

gtggtgggtg tgtggcgcgt ggccaagctc ttccgcctgg cgcggcttga ggaccagtgc    420

actgagtaca tggccaaggt cattgagaag ctggtggagc gggaggactt cgtggaggcg    480

gtgaaggagg aggcagcggc tgtggcagcc cggcaggaga cggactctat cccgctggtg    540

gacgacatcc gcttccacgt ggccagcacg gtgcagacct acagcgccat agaggaggcg    600

cagcagcgtc tgcgggcact cgaggacctg ctcgtgtcca tcggtctgga ctgttgagcc    660

cctggctggg cagccccagg ggccaggagc tctcttggag acaagcatgt gtatgcgttt    720

gtgtgcagct cttcttcctg ctccctgcac attgagggct tcatgggggg tgcgaggggc    780

tcagtggggc ttctcttccc tccatgagcc tggagacccc aggggaggat ccatttggga    840

tgagccccct ccccccaatg cacaagccag cccccaagac cctgggggtg gacaccactc    900

agggaaacct ggggtggggg tgggctttgg tcttagcact ttccttctcc agatcccccc    960

tacccacccc agtcccaaat ccagtcctct ggcccttgcc tagccctgaa ttgcttctct   1020

aagctggtgt tcccatgcac agggccattc aggaagggct gggggagtgt gtgtggcaat   1080

aaagcttgaa ggcaccgtgg gagcatg                                       1107


<210>  9754
<211>  142
<212>  PRT
<213>  Homosapiens

<400>  9754

Met Tyr Ser Asp His Thr Glu Leu Ser Pro Glu Ala Ala Tyr Asp Val 
1               5                   10                  15      


Leu Ser Val Ala Asp Met Tyr Leu Leu Pro Gly Leu Lys Arg Leu Cys 
            20                  25                  30          


Gly Arg Ser Leu Ala Gln Met Leu Asp Glu Asp Thr Val Val Gly Val 
        35                  40                  45              


Trp Arg Val Ala Lys Leu Phe Arg Leu Ala Arg Leu Glu Asp Gln Cys 
    50                  55                  60                  


Thr Glu Tyr Met Ala Lys Val Ile Glu Lys Leu Val Glu Arg Glu Asp 
65                  70                  75                  80  


Phe Val Glu Ala Val Lys Glu Glu Ala Ala Ala Val Ala Ala Arg Gln 
                85                  90                  95      


Glu Thr Asp Ser Ile Pro Leu Val Asp Asp Ile Arg Phe His Val Ala 
            100                 105                 110         


Ser Thr Val Gln Thr Tyr Ser Ala Ile Glu Glu Ala Gln Gln Arg Leu 
        115                 120                 125             


Arg Ala Leu Glu Asp Leu Leu Val Ser Ile Gly Leu Asp Cys 
    130                 135                 140         


<210>  9755
<211>  787
<212>  DNA
<213>  Homosapiens

<400>  9755
aggtcgttcg gctcgggtac catcctccgc gccatggaca ccagcgacct gttcgccagc     60

tgcaggaagg gggatgtggg ccgagtgcgg tacctgctgg agcagcgaga cgtggaggtg    120

aatgtgcggg acaagtggga cagcaccccc ttgtactatg cctgcttgtg tgggcacgag    180

gagctggtac tctaccttct ggccaatgga gcccgctgcg aggccaacac cttcgatggt    240

gagcgctgcc tctatggggc actgagtgac cccatccgcc gggctctacg cgattacaag    300

caggtcacgg cttcctgcag gaggcgggat tactatgacg acttcttgca gcggcttcta    360

gagcagggca tccacagtga cgtggtcttt gtagtacacg ggaagccatt ccgggtgcat    420

cgctgcgtcc tgggtgcacg tagtgcctac tttgccaaca tgctggacac caaatggaag    480

ggcaagagtg tcgtggttct caggcaccca ctgatcaacc ccgtggcctt tggggccctg    540

ctgcagtacc tgtacacagg tgaccccctg ggtccagggt aggaggagag ggagtgggcc    600

gtccttctgg acagcagtac acctaggtgt ggctgggctg acctttcacc tctagacact    660

tcatggtccc cccggggtgg ttccagctgc ctctcgggtt gggttgcaag agagaggact    720

agtgtgcctg ctcaggaaga gcttgtccca cccacatgct gaggccctcc catctgttcc    780

ctggggc                                                              787


<210>  9756
<211>  182
<212>  PRT
<213>  Homosapiens

<400>  9756

Met Asp Thr Ser Asp Leu Phe Ala Ser Cys Arg Lys Gly Asp Val Gly 
1               5                   10                  15      


Arg Val Arg Tyr Leu Leu Glu Gln Arg Asp Val Glu Val Asn Val Arg 
            20                  25                  30          


Asp Lys Trp Asp Ser Thr Pro Leu Tyr Tyr Ala Cys Leu Cys Gly His 
        35                  40                  45              


Glu Glu Leu Val Leu Tyr Leu Leu Ala Asn Gly Ala Arg Cys Glu Ala 
    50                  55                  60                  


Asn Thr Phe Asp Gly Glu Arg Cys Leu Tyr Gly Ala Leu Ser Asp Pro 
65                  70                  75                  80  


Ile Arg Arg Ala Leu Arg Asp Tyr Lys Gln Val Thr Ala Ser Cys Arg 
                85                  90                  95      


Arg Arg Asp Tyr Tyr Asp Asp Phe Leu Gln Arg Leu Leu Glu Gln Gly 
            100                 105                 110         


Ile His Ser Asp Val Val Phe Val Val His Gly Lys Pro Phe Arg Val 
        115                 120                 125             


His Arg Cys Val Leu Gly Ala Arg Ser Ala Tyr Phe Ala Asn Met Leu 
    130                 135                 140                 


Asp Thr Lys Trp Lys Gly Lys Ser Val Val Val Leu Arg His Pro Leu 
145                 150                 155                 160 


Ile Asn Pro Val Ala Phe Gly Ala Leu Leu Gln Tyr Leu Tyr Thr Gly 
                165                 170                 175     


Asp Pro Leu Gly Pro Gly 
            180         


<210>  9757
<211>  2694
<212>  DNA
<213>  Homosapiens

<400>  9757
agagcccata atcggcctcc ggtccctgag gattcggaaa ctcctgacgc agctaaagtg     60

aatctggcgc tgagatgccc cctccatggg ccggacgcgg agggaagggg tgcccagttg    120

ggttctgggg cccttcccct ccttgggctt ccactatccc gtttgacctc cttttttctt    180

ggcccttcct cccccttgac ctggtgctga ctgactgctt ccacctcccc tgggctggcg    240

ccgggctgct gtactcccgt agcctccctg ggccgctccc tgacatcccg tgccactcaa    300

gagttagtgc atagtgtcaa cgctgagtgg gttcacagca cttccaggtg cagcctggag    360

gcctcctttg ggctgccccc gcctcagtgg ggctgcatta gcattggcga ctcccctcgc    420

tcaccttccg catcccatca gttgctgtat cccgcgactc ctgcctccta gaattgtgtg    480

ccctccacac catcaggagg cctgcagcag ctttttcccg ggctccctgc ttctaacagg    540

gccagcttct tcctgcagta gagagctctg gtgggagtga aggctccatc acctcctctc    600

ccaaacgctg aaaggccaaa ggtccagcct cggcactggc tctggcttct gtccctgtag    660

cccatcgtcc cccagcactg atagcacaca gtgtctgcct gttcgacccc acctccacat    720

ccttgcctgc actttgcctt gagtgcctct cctgctctgg tctgcctgtc acctgccctc    780

acctggggga ggcttcccca taccaaaagg gatgttttct ctccgttcct ttccacgggc    840

cttctttctc agaccatgaa cccgtcctga cccaggctct gacctccttc ctgcccaggt    900

acctgctgga gcagcgagac gtggaggtac tatgcctgct tgtgtgggca cgaggagctg    960

gtactctacc ttctggccaa tggagcccgc tgcgaggcca acaccttcga tggtgagcgc   1020

tgcctctatg gggcactgag tgaccccatc cgccgggctc tacgcgatta caagcaggtc   1080

acggcttcct gcaggaggcg ggattactat gacgacttct tgcagcggct tctagagcag   1140

ggcatccaca gtgacgtggt ctttgtagta cacgggaagc cattccgggt gcatcgctgc   1200

gtcctgggtg cacgtagtgc ctactttgcc aacatgctgg acaccaaatg gaagggcaag   1260

agtgtcgtgg ttctcaggca cccactgatc aaccccgtgg cctttggggc cctgctgcag   1320

tacctgtaca caggccgcct ggacattggc gtagagcatg tgagtgactg tgagcgcctg   1380

gccaagcaat gccagctgtg ggacctgctc agcgacctgg aggccaagtg cgagaaggtg   1440

tctgagtttg tggcgtctaa gccaggcacg tgtgtgaagg tgctgaccat cgagccccca   1500

cctgcagacc cccgcctccg ggaggacatg gcgctgctgg ccgattgtgc cctgcccccc   1560

gagctccgag gtgatctttg ggagctgccc ttcccttgtc ctgacggctt caacagctgc   1620

cctgacatct gcttccgagt ggctggctgc agcttcctct gccacaaggc ctttttctgt   1680

ggccgcagtg actacttccg agccctgctg gatgaccact tccgagagag cgaggagcca   1740

gcgacctcag ggggcccccc agccgtcacc ctgcatggca tctcacccga cgtcttcact   1800

cacgtgctct actacatgta cagcgaccac actgagctgt cccccgaggc agcctatgat   1860

gtgctgagcg tcgccgacat gtacctgctg ccaggcctga agaggctgtg cggccgcagc   1920

ctggctcaga tgctagacga ggacactgtg gtgggtgtgt ggcgcgtggc caagctcttc   1980

cgcctggcgc ggcttgagga ccagtgcact gagtacatgg ccaaggtcat tgagaagctg   2040

gtggagcggg aggacttcgt ggaggcggtg aaggaggagg cagcggctgt ggcagcccgg   2100

caggagacgg actctatccc gctggtggac gacatccgct tccacgtggc cagcacggtg   2160

cagacctaca gcgccataga ggaggcgcag cagcgtctgc gggcactcga ggacctgctc   2220

gtgtccatcg gtctggactg ttgagcccct ggctgggcag ccccaggggc caggagctct   2280

cttggagaca agcatgtgta tgcgtttgtg tgcagctctt cttcctgctc cctgcacatt   2340

gagggcttca tggggggtgc gaggggctca gtggggcttc tcttccctcc atgagcctgg   2400

agaccccagg ggaggatcca tttgggatga gccccctccc cccaatgcac aagccagccc   2460

ccaagaccct gggggtggac accactcagg gaaacctggg gtgggggtgg gctttggtct   2520

tagcactttc cttctccaga tcccccctac ccaccccagt cccaaatcca gtcctctggc   2580

ccttgcctag ccctgaattg cttctctaag ctggtgttcc catgcacagg gccattcagg   2640

aagggctggg ggagtgtgtg tggcaataaa gcttgaaggc accgtgggag catg         2694


<210>  9758
<211>  336
<212>  PRT
<213>  Homosapiens

<400>  9758

Met Leu Asp Thr Lys Trp Lys Gly Lys Ser Val Val Val Leu Arg His 
1               5                   10                  15      


Pro Leu Ile Asn Pro Val Ala Phe Gly Ala Leu Leu Gln Tyr Leu Tyr 
            20                  25                  30          


Thr Gly Arg Leu Asp Ile Gly Val Glu His Val Ser Asp Cys Glu Arg 
        35                  40                  45              


Leu Ala Lys Gln Cys Gln Leu Trp Asp Leu Leu Ser Asp Leu Glu Ala 
    50                  55                  60                  


Lys Cys Glu Lys Val Ser Glu Phe Val Ala Ser Lys Pro Gly Thr Cys 
65                  70                  75                  80  


Val Lys Val Leu Thr Ile Glu Pro Pro Pro Ala Asp Pro Arg Leu Arg 
                85                  90                  95      


Glu Asp Met Ala Leu Leu Ala Asp Cys Ala Leu Pro Pro Glu Leu Arg 
            100                 105                 110         


Gly Asp Leu Trp Glu Leu Pro Phe Pro Cys Pro Asp Gly Phe Asn Ser 
        115                 120                 125             


Cys Pro Asp Ile Cys Phe Arg Val Ala Gly Cys Ser Phe Leu Cys His 
    130                 135                 140                 


Lys Ala Phe Phe Cys Gly Arg Ser Asp Tyr Phe Arg Ala Leu Leu Asp 
145                 150                 155                 160 


Asp His Phe Arg Glu Ser Glu Glu Pro Ala Thr Ser Gly Gly Pro Pro 
                165                 170                 175     


Ala Val Thr Leu His Gly Ile Ser Pro Asp Val Phe Thr His Val Leu 
            180                 185                 190         


Tyr Tyr Met Tyr Ser Asp His Thr Glu Leu Ser Pro Glu Ala Ala Tyr 
        195                 200                 205             


Asp Val Leu Ser Val Ala Asp Met Tyr Leu Leu Pro Gly Leu Lys Arg 
    210                 215                 220                 


Leu Cys Gly Arg Ser Leu Ala Gln Met Leu Asp Glu Asp Thr Val Val 
225                 230                 235                 240 


Gly Val Trp Arg Val Ala Lys Leu Phe Arg Leu Ala Arg Leu Glu Asp 
                245                 250                 255     


Gln Cys Thr Glu Tyr Met Ala Lys Val Ile Glu Lys Leu Val Glu Arg 
            260                 265                 270         


Glu Asp Phe Val Glu Ala Val Lys Glu Glu Ala Ala Ala Val Ala Ala 
        275                 280                 285             


Arg Gln Glu Thr Asp Ser Ile Pro Leu Val Asp Asp Ile Arg Phe His 
    290                 295                 300                 


Val Ala Ser Thr Val Gln Thr Tyr Ser Ala Ile Glu Glu Ala Gln Gln 
305                 310                 315                 320 


Arg Leu Arg Ala Leu Glu Asp Leu Leu Val Ser Ile Gly Leu Asp Cys 
                325                 330                 335     


<210>  9759
<211>  4298
<212>  DNA
<213>  Homosapiens

<400>  9759
ccaggttggt ctcaaactcc tgagcccaag tgatccacct accttggtct cgcaaagtgc     60

ctggattata ggtgtgagct gccacgccca ggcttgtttt tcttaatagt ccctgccatc    120

gttaggtagt gggttgattg tcctgcctca ctagagtata agttcagcag gacagggacc    180

tgtgtctcgt tcactgctgt gctccagtgt gtgggacaag cccagccacc aagtcagctc    240

tccgttctgt gttgtctgtc ttccgtgtga gtgagtatgt gcctgtgtga gtgcacacag    300

acgtgcccat tcgcctagcc cttgactggg agggtgttgg ggtcagagtg ggcccagggt    360

aatttgggaa ggcatcgcca gagattcgga gccccatgtg tgggaaggtg gggaggaggg    420

acagggagat tagaatttcc cccaggcccc ttccctgcta actggtgagc cctgcctccc    480

ccaggagccc gctgcgaggc caacaccttc gatggtgagc gctgcctcta tggggcactg    540

agtgacccca tccgccgggc tctacgcgat tacaagcagg tcacggcttc ctgcaggagg    600

cgggattact atgacgactt cttgcagcgg tgagccaggg cacacgaggg gtgcagcatg    660

gggtgcggtg gccctggtgg gtgtggcgag tctgctctga ctgtggcctg cactgggttc    720

tgagtgctcc gaggaatggg gtggggctgt gccaagtatc ctccctcctg gcttgtccct    780

ccccaggctt ctagagcagg gcatccacag tgacgtggtc tttgtagtac acgggaagcc    840

attccgggtg catcgctgcg tcctgggtgc acgtagtgcc tactttgcca acatgctgga    900

caccaaatgg aagggcaaga gtgtcgtggt tctcaggcac ccactgatca accccgtggc    960

ctttggggcc ctgctgcagt acctgtacac aggtgacccc ctgggtccag ggtaggagga   1020

gagggagtgg gccgtccttc tggacagcag tacacctagg tgtggctggg ctgacctttc   1080

acctctagac acttcatggt ccccccgggg tggttccagc tgcctctcgg gttgggttgc   1140

aagagagagg actagtgtgc ctgctcagga agagcttgtc ccacccacat gctgaggccc   1200

tcccatctgt tccctggggc ctgtagaaca gcttttgatg gggaaaccat ggtggcaagt   1260

gggcccagga gtcctagtcc tgcagccagg tggccaggtg ggaggggatc accctttttc   1320

tgtgggcctg atgacagctg aggtcccgca ggccctcatc ctccccactg cccccaggcc   1380

gcctggacat tggcgtagag catgtgagtg actgtgagcg cctggccaag caatgccagc   1440

tgtgggacct gctcagcgac ctggaggcca agtgcgagaa ggtgtctgag tttggtgcga   1500

gcagggtttg gggcccgggg ccatgggtgc ggcctggcag ggctggcctg gctccctgaa   1560

gttgttcttc ccctgtagtg gcgtctaagc caggcacgtg tgtgaaggtg ctgaccatcg   1620

agcccccacc tgcagacccc cgcctccggg aggacatggc gctgctggcc gattgtgccc   1680

tgccccccga gctccgaggt gatctttggg agctgccctt cccttgtcct gacggcttca   1740

acagctgccc tgacatctgc ttccgagtgg ctggctgcag cttcctctgc cacaaggtgc   1800

ctgtgccctc ctgttgcccc tggccccagc ccgttgccct gagcccccgt ctagctcctc   1860

aggagacaga ccctggccct cacacttcct gagcccggcc tcccccaggc ctttttctgt   1920

ggccgcagtg actacttccg agccctgctg gatgaccact tccgagagag cgaggagcca   1980

gcgacctcag ggggcccccc agccgtcacc ctgcatggca tctcacccga cgtcttcact   2040

cacgtgctct actacatgta cagcgaccac actgaggtgg gggctcaggc agagctgggg   2100

atggcacaca acctgtgctg ccgtgggctg agagggagcg ccagggccct gggggtctgt   2160

ggaagggccc agctggcccc atggttgacg ttttgagaag gctggagggg aaggctgtgg   2220

gactttggat ttttctttca ggtagaggaa gccttgttgg gctccagaga gaggatgagt   2280

gatgagcctg tgtcacagac actccacact tgtcagccac ttgggatcct cagcttctct   2340

agcaggaggg tggagggtgg gtggggacag cctcctctct gtggtgctgc agatccctgg   2400

ggttctgggt tcccagtctc ctcttccctt gctgcctgcc tctgtctcca gctgccccaa   2460

ggtgtccgta agccaaggct gcagggcagc agcagagtgc tgaaggtttg ctctgccagg   2520

gtgtgtgaga gagagagaga gtgtgtgtgt gcgtgcgcgt gcgcgcgcac tataaagcaa   2580

tccccatatc tggtggctta aagaagaggg gagtttgttt ctccttcact tctgactgag   2640

gtgggtgccc cagggcaagt ggcttgcgga agatcaggtc atccctccat cttgcccctg   2700

tatgcctaag ggtgaaggtc aaaaaccttt tctctgaagg tgagtgtttc aggttctgtg   2760

ggccatatgg ccctgttgta gctactcaac tctgtagcgc aaaggtagcc agagacagta   2820

cagagatgag tgggtgaggc tgcattccaa taaaacttta cttgcacaaa caggctggat   2880

ttggtccaca ggccgtagct tacccatcct gcctggggca tcgcgtttgg ccatggagat   2940

tgggtcctag gcaaactcat gctctaggag gaagaggaag gcagggcaag caatgctgtt   3000

tttgtagaag ccaccggaaa ttgcaccact tctcatgttc ccctggagag aacttcgtgc   3060

ctacctgcca acaagggagg cttggaaagt cattctgtgg ccagggccct gttttgtggg   3120

ggaaggggag gaagcatgct gggagacaga gggcagtccc tactgctgct ctatctccag   3180

tggcagctcc cttgtccatc cctccgcgcg gcctgacagc ccctcagcct ccatctttcc   3240

caccccctct actgggcatc tcctgcagct cagcccagct ctctggcccc tgtagcaggg   3300

gttacctttg cccaccctgg agaagctccc tcttcaagga gcctcgccac ccaaagggca   3360

ccttgtctca gagtgtggct tgggctctta acctgggttg atactggttg agctgtgtga   3420

cactgggtga gctttgtgat cttgggccag ttacttaact gctctgtgcc tctagaacat   3480

ggggatagct ctcgtcgtca cttcctaagg ccttgtgcag atgcatgggt tacccaggta   3540

aaggaggtgg catggcacat ggcacatggc ttgtaatgtg gtcgcagagc tccccttgtc   3600

tctgtctgca gcttgctccc tgtgccaccc aggctctggc ctgaatctga gggcttcagt   3660

cttatccagc acaggatgta tctgtaggtg ggctctgtgt ccccacagcc tcttgagagg   3720

gagggagctg gtagatagtc tcccacccct ggcagagtcc ctgcataggt cttgactagc   3780

tgcctctgtc ccaccattct gacagccccc gcaggtaggc atggttatct atacctcatg   3840

gactgggaac tagaggcaca gggaggtgca gtgacttgcc cagggcccca cagctagaag   3900

tgtcagaccc aggtctgtat aactcggagc tcagaccctg gctcctgcga gggccctgcc   3960

tcccgcctgc cctgccagcc tgctcagggc atgggagaac cccccagtct tctgccccct   4020

agcggtcctg cagatccctg tgggaatctg ggccagcccc ccgaccccca accccataca   4080

tgcgcaggga gctcctactc ccactggaag ccttcccgcc agtgcccccc aaccaccaca   4140

ggccctagcc ttggctgttg tgccctggga gcccttggtg acctcggggg gcaccttcat   4200

ccctgtcttc actgcagctg tcccccgagg cagcctatga tgtgctgagc gtcgccgaca   4260

tgtacctgct gccaggcctg aagaggctgt gcggccgc                           4298


<210>  9760
<211>  78
<212>  PRT
<213>  Homosapiens

<400>  9760

Met Ala Leu Leu Ala Asp Cys Ala Leu Pro Pro Glu Leu Arg Gly Asp 
1               5                   10                  15      


Leu Trp Glu Leu Pro Phe Pro Cys Pro Asp Gly Phe Asn Ser Cys Pro 
            20                  25                  30          


Asp Ile Cys Phe Arg Val Ala Gly Cys Ser Phe Leu Cys His Lys Val 
        35                  40                  45              


Pro Val Pro Ser Cys Cys Pro Trp Pro Gln Pro Val Ala Leu Ser Pro 
    50                  55                  60                  


Arg Leu Ala Pro Gln Glu Thr Asp Pro Gly Pro His Thr Ser 
65                  70                  75              


<210>  9761
<211>  316
<212>  DNA
<213>  Homosapiens

<400>  9761
gagtctgctc tgactgtggc ctgcactggg ttctgagtgc tccgaggaat ggggtggggc     60

tgtgccaagt atcctccctc ctggcttgtc cctccccagg cttctagagc agggcatcca    120

cagtgacgtg gtctttgtag tacacgggaa gccattccgg gtgcatcgct gcgtcctggg    180

tgcacgtagt gcctactttg ccaacatgct ggacaccaaa tggaagggca agagtgtcgt    240

ggttctcagg cacccactga tcaaccccgt ggcctttggg gccctgctgc agtacctgta    300

cacaggccgc ctggac                                                    316


<210>  9762
<211>  36
<212>  PRT
<213>  Homosapiens

<400>  9762

Met Leu Asp Thr Lys Trp Lys Gly Lys Ser Val Val Val Leu Arg His 
1               5                   10                  15      


Pro Leu Ile Asn Pro Val Ala Phe Gly Ala Leu Leu Gln Tyr Leu Tyr 
            20                  25                  30          


Thr Gly Arg Leu 
        35      


<210>  9763
<211>  1293
<212>  DNA
<213>  Homosapiens

<400>  9763
gacctgctca gcgacctgga ggccaagtgc gagaaggtgt ctgagtttgt ggcgtctaag     60

ccaggcacgt gtgtgaaggt gctgaccatc gagcccccac ctgcagaccc ccgcctccgg    120

gaggacatgg cgctgctggc cgattgtgcc ctgccccccg agctccgagg tgatctttgg    180

gagctgccct tcccttgtcc tgacggcttc aacagctgcc ctgacatctg cttccgagtg    240

gctggctgca gcttcctctg ccacaaggcc tttttctgtg gccgcagtga ctacttccga    300

gccctgctgg atgaccactt ccgagagagc gaggagccag cgacctcagg gggcccccca    360

gccgtcaccc tgcatggcat ctcacccgac gtcttcactc acgtgctcta ctacatgtac    420

agcgaccaca ctgagctgtc ccccgaggca gcctatgatg tgctgagcgt cgccgacatg    480

tacctgctgc caggcctgaa gaggctgtgc ggccgcagcc tggctcagat gctagacgag    540

gacactgtgg tgggtgtgtg gcgcgtggcc aagctcttcc gcctggcgcg gcttgaggac    600

cagtgcactg agtacatggc caaggtcatt gagaagctgg tggagcggga ggacttcgtg    660

gaggcggtga aggaggaggc agcggctgtg gcagcccggc aggagacgga ctctatcccg    720

ctggtggacg acatccgctt ccacgtggcc agcacggtgc agacctacag cgccatagag    780

gaggcgcagc agcgtctgcg ggcactcgag gacctgctcg tgtccatcgg tctggactgt    840

tgagcccctg gctgggcagc cccaggggcc aggagctctc ttggagacaa gcatgtgtat    900

gcgtttgtgt gcagctcttc ttcctgctcc ctgcacattg agggcttcat ggggggtgcg    960

aggggctcag tggggcttct cttccctcca tgagcctgga gaccccaggg gaggatccat   1020

ttgggatgag ccccctcccc ccaatgcaca agccagcccc caagaccctg ggggtggaca   1080

ccactcaggg aaacctgggg tgggggtggg ctttggtctt agcactttcc ttctccagat   1140

cccccctacc caccccagtc ccaaatccag tcctctggcc cttgcctagc cctgaattgc   1200

ttctctaagc tggtgttccc atgcacaggg ccattcagga agggctgggg gagtgtgtgt   1260

ggcaataaag cttgaaggca ccgtgggagc atg                                1293


<210>  9764
<211>  238
<212>  PRT
<213>  Homosapiens

<400>  9764

Met Ala Leu Leu Ala Asp Cys Ala Leu Pro Pro Glu Leu Arg Gly Asp 
1               5                   10                  15      


Leu Trp Glu Leu Pro Phe Pro Cys Pro Asp Gly Phe Asn Ser Cys Pro 
            20                  25                  30          


Asp Ile Cys Phe Arg Val Ala Gly Cys Ser Phe Leu Cys His Lys Ala 
        35                  40                  45              


Phe Phe Cys Gly Arg Ser Asp Tyr Phe Arg Ala Leu Leu Asp Asp His 
    50                  55                  60                  


Phe Arg Glu Ser Glu Glu Pro Ala Thr Ser Gly Gly Pro Pro Ala Val 
65                  70                  75                  80  


Thr Leu His Gly Ile Ser Pro Asp Val Phe Thr His Val Leu Tyr Tyr 
                85                  90                  95      


Met Tyr Ser Asp His Thr Glu Leu Ser Pro Glu Ala Ala Tyr Asp Val 
            100                 105                 110         


Leu Ser Val Ala Asp Met Tyr Leu Leu Pro Gly Leu Lys Arg Leu Cys 
        115                 120                 125             


Gly Arg Ser Leu Ala Gln Met Leu Asp Glu Asp Thr Val Val Gly Val 
    130                 135                 140                 


Trp Arg Val Ala Lys Leu Phe Arg Leu Ala Arg Leu Glu Asp Gln Cys 
145                 150                 155                 160 


Thr Glu Tyr Met Ala Lys Val Ile Glu Lys Leu Val Glu Arg Glu Asp 
                165                 170                 175     


Phe Val Glu Ala Val Lys Glu Glu Ala Ala Ala Val Ala Ala Arg Gln 
            180                 185                 190         


Glu Thr Asp Ser Ile Pro Leu Val Asp Asp Ile Arg Phe His Val Ala 
        195                 200                 205             


Ser Thr Val Gln Thr Tyr Ser Ala Ile Glu Glu Ala Gln Gln Arg Leu 
    210                 215                 220                 


Arg Ala Leu Glu Asp Leu Leu Val Ser Ile Gly Leu Asp Cys 
225                 230                 235             


<210>  9765
<211>  2986
<212>  DNA
<213>  Homosapiens

<400>  9765
cagagctggg gatggcacac aacctgtgct gccgtgggct gagagggagc gccagggccc     60

tgggggtctg tggaagggcc cagctggccc catggttgac gttttgagaa ggctggaggg    120

gaaggctgtg ggactttgga tttttctttc aggtagagga agccttgttg ggctccagag    180

agaggatgag tgatgagcct gtgtcacaga cactccacac ttgtcagcca cttgggatcc    240

tcagcttctc tagcaggagg gtggagggtg ggtggggaca gcctcctctc tgtggtgctg    300

cagatccctg gggttctggg ttcccagtct cctcttccct tgctgcctgc ctctgtctcc    360

agctgcccca aggtgtccgt aagccaaggc tgcagggcag cagcagagtg ctgaaggttt    420

gctctgccag ggtgtgtgag agagagagag agtgtgtgtg tgcgtgcgcg tgcgcgcgca    480

ctataaagca atccccatat ctggtggctt aaagaagagg ggagtttgtt tctccttcac    540

ttctgactga ggtgggtgcc ccagggcaag tggcttgcgg aagatcaggt catccctcca    600

tcttgcccct gtatgcctaa gggtgaaggt caaaaacctt ttctctgaag gtgagtgttt    660

caggttctgt gggccatatg gccctgttgt agctactcaa ctctgtagcg caaaggtagc    720

cagagacagt acagagatga gtgggtgagg ctgcattcca ataaaacttt acttgcacaa    780

acaggctgga tttggtccac aggccgtagc ttacccatcc tgcctggggc atcgcgtttg    840

gccatggaga ttgggtccta ggcaaactca tgctctagga ggaagaggaa ggcagggcaa    900

gcaatgctgt ttttgtagaa gccaccggaa attgcaccac ttctcatgtt cccctggaga    960

gaacttcgtg cctacctgcc aacaagggag gcttggaaag tcattctgtg gccagggccc   1020

tgttttgtgg gggaagggga ggaagcatgc tgggagacag agggcagtcc ctactgctgc   1080

tctatctcca gtggcagctc ccttgtccat ccctccgcgc ggcctgacag cccctcagcc   1140

tccatctttc ccaccccctc tactgggcat ctcctgcagc tcagcccagc tctctggccc   1200

ctgtagcagg ggttaccttt gcccaccctg gagaagctcc ctcttcaagg agcctcgcca   1260

cccaaagggc accttgtctc agagtgtggc ttgggctctt aacctgggtt gatactggtt   1320

gagctgtgtg acactgggtg agctttgtga tcttgggcca gttacttaac tgctctgtgc   1380

ctctagaaca tggggatagc tctcgtcgtc acttcctaag gccttgtgca gatgcatggg   1440

ttacccaggt aaaggaggtg gcatggcaca tggcacatgg cttgtaatgt ggtcgcagag   1500

ctccccttgt ctctgtctgc agcttgctcc ctgtgccacc caggctctgg cctgaatctg   1560

agggcttcag tcttatccag cacaggatgt atctgtaggt gggctctgtg tccccacagc   1620

ctcttgagag ggagggagct ggtagatagt ctcccacccc tggcagagtc cctgcatagg   1680

tcttgactag ctgcctctgt cccaccattc tgacagcccc cgcaggtagg catggttatc   1740

tatacctcat ggactgggaa ctagaggcac agggaggtgc agtgacttgc ccagggcccc   1800

acagctagaa gtgtcagacc caggtctgta taactcggag ctcagaccct ggctcctgcg   1860

agggccctgc ctcccgcctg ccctgccagc ctgctcaggg catgggagaa ccccccagtc   1920

ttctgccccc tagcggtcct gcagatccct gtgggaatct gggccagccc cccgaccccc   1980

aaccccatac atgcgcaggg agctcctact cccactggaa gccttcccgc cagtgccccc   2040

caaccaccac aggccctagc cttggctgtt gtgccctggg agcccttggt gacctcgggg   2100

ggcaccttca tccctgtctt cactgcagct gtcccccgag gcagcctatg atgtgctgag   2160

cgtcgccgac atgtacctgc tgccaggcct gaagaggctg tgcggccgca gcctggctca   2220

gatgctagac gaggacactg tggtgggtgt gtggcgcgtg gccaagctct tccgcctggc   2280

gcggcttgag gaccagtgca ctgagtacat ggccaaggtc attgagaagc tggtggagcg   2340

ggaggacttc gtggaggcgg tgaaggagga ggcagcggct gtggcagccc ggcaggagac   2400

ggactctatc ccgctggtgg acgacatccg cttccacgtg gccagcacgg tgcagaccta   2460

cagcgccata gaggaggcgc agcagcgtct gcgggcactc gaggacctgc tcgtgtccat   2520

cggtctggac tgttgagccc ctggctgggc agccccaggg gccaggagct ctcttggaga   2580

caagcatgtg tatgcgtttg tgtgcagctc ttcttcctgc tccctgcaca ttgagggctt   2640

catggggggt gcgaggggct cagtggggct tctcttccct ccatgagcct ggagacccca   2700

ggggaggatc catttgggat gagccccctc cccccaatgc acaagccagc ccccaagacc   2760

ctgggggtgg acaccactca gggaaacctg gggtgggggt gggctttggt cttagcactt   2820

tccttctcca gatcccccct acccacccca gtcccaaatc cagtcctctg gcccttgcct   2880

agccctgaat tgcttctcta agctggtgtt cccatgcaca gggccattca ggaagggctg   2940

ggggagtgtg tgtggcaata aagcttgaag gcaccgtggg agcatg                  2986


<210>  9766
<211>  121
<212>  PRT
<213>  Homosapiens

<400>  9766

Met Tyr Leu Leu Pro Gly Leu Lys Arg Leu Cys Gly Arg Ser Leu Ala 
1               5                   10                  15      


Gln Met Leu Asp Glu Asp Thr Val Val Gly Val Trp Arg Val Ala Lys 
            20                  25                  30          


Leu Phe Arg Leu Ala Arg Leu Glu Asp Gln Cys Thr Glu Tyr Met Ala 
        35                  40                  45              


Lys Val Ile Glu Lys Leu Val Glu Arg Glu Asp Phe Val Glu Ala Val 
    50                  55                  60                  


Lys Glu Glu Ala Ala Ala Val Ala Ala Arg Gln Glu Thr Asp Ser Ile 
65                  70                  75                  80  


Pro Leu Val Asp Asp Ile Arg Phe His Val Ala Ser Thr Val Gln Thr 
                85                  90                  95      


Tyr Ser Ala Ile Glu Glu Ala Gln Gln Arg Leu Arg Ala Leu Glu Asp 
            100                 105                 110         


Leu Leu Val Ser Ile Gly Leu Asp Cys 
        115                 120     


<210>  9767
<211>  504
<212>  DNA
<213>  Homosapiens

<400>  9767
ttgctccctg tgccacccag gctctggcct gaatctgagg gcttcagtct tatccagcac     60

aggatgtatc tgtaggtggg ctctgtgtcc ccacagcagc tagaagtgtc agacccaggt    120

ctgtataact cggagctcag accctggctc ctgcgagggc cctgcctccc gcctgccctg    180

ccagcctgct cagggcatgg gagaaccccc cagtcttctg ccccctagcg gtcctgcaga    240

tccctgtggg aatctgggcc agccccccga cccccaaccc catacatgcg cagggagctc    300

ctactcccac tggaagcctt cccgccagtg ccccccaacc accacaggcc ctagccttgg    360

ctgttgtgcc ctgggagccc ttggtgacct cggggggcac cttcatccct gtcttcactg    420

cagctgtccc ccgaggcagc ctatgatgtg ctgagcgtcg ccgacatgta cctgctgcca    480

ggcctgaaga ggctgtgcgg ccgc                                           504


<210>  9768
<211>  85
<212>  PRT
<213>  Homosapiens

<400>  9768

Met Gly Glu Pro Pro Ser Leu Leu Pro Pro Ser Gly Pro Ala Asp Pro 
1               5                   10                  15      


Cys Gly Asn Leu Gly Gln Pro Pro Asp Pro Gln Pro His Thr Cys Ala 
            20                  25                  30          


Gly Ser Ser Tyr Ser His Trp Lys Pro Ser Arg Gln Cys Pro Pro Thr 
        35                  40                  45              


Thr Thr Gly Pro Ser Leu Gly Cys Cys Ala Leu Gly Ala Leu Gly Asp 
    50                  55                  60                  


Leu Gly Gly His Leu His Pro Cys Leu His Cys Ser Cys Pro Pro Arg 
65                  70                  75                  80  


Gln Pro Met Met Cys 
                85  


<210>  9769
<211>  490
<212>  DNA
<213>  Homosapiens

<400>  9769
ccacggtgcc ttcaagcttt attgccacac acactccccc agcccttcct gaatggccct     60

gtgcatggga acaccagctt agagaagcaa ttcagggcta ggcaagggcc agaggactgg    120

atttgggact ggggtgggta ggggggatct ggagaaggaa agtgctaaga ccaaagccca    180

cccccacccc aggtttccct gagtggtgtc cacccccagg gtcttggggg ctggcttgtg    240

cattgggggg agggggctca tcccaaatgg atcctcccct ggggtctcca ggctcatgga    300

gggaagagaa gccccactga gcccctcgca ccccccatga agccctcaat gtgcagggag    360

caggaagaag agctgcacac aaacgcatac acatgcttgt ctccaagaga gcttggccat    420

gtactcagtg cactggtcct caagccgcgc caggcggaag agcttggcca cgcgccacac    480

acccaccaca                                                           490


<210>  9770
<211>  50
<212>  PRT
<213>  Homosapiens

<400>  9770

Met Lys Pro Ser Met Cys Arg Glu Gln Glu Glu Glu Leu His Thr Asn 
1               5                   10                  15      


Ala Tyr Thr Cys Leu Ser Pro Arg Glu Leu Gly His Val Leu Ser Ala 
            20                  25                  30          


Leu Val Leu Lys Pro Arg Gln Ala Glu Glu Leu Gly His Ala Pro His 
        35                  40                  45              


Thr His 
    50  


<210>  9771
<211>  2724
<212>  DNA
<213>  Homosapiens

<400>  9771
agatttatga aggtgcctac catgttctcc acaaggagct tcctgaagtc accaactccg     60

tcttccatga aataaacatg tgggtctctc aaaggacagc cacggcagga actgcgtccc    120

caccctgaat gcattggccg gtgcccggct catggtctgg gggatgcagg caggggaagg    180

gcagagatgg cttctcagat atggcttgcc aaaaaaaaaa aaaaaaaaaa atcagaaatt    240

ggagaaatcc ttagcacaat tttctaaaaa ataacagaca tttttgttat acattagact    300

atcagacact ggacctacct taatggttag acactttatg caaaaaaaga gaaaggtccc    360

aggtgatttt ccacaaagaa tgtgctaaaa tgtccactga aaacaaagcc aagcctctgc    420

cctgcctctc ccagctccca caagggttcc aggaattcct ggtgttccca ggacaccaga    480

ctgcaataac tggaggcgcc tccttcctgc ccacccttcg ctcacgcccc agcgccctct    540

ctgaccagcc tccgcttggt ggccttcctc tggccgtgtg atgaggtggt tgctgtctcc    600

ataggggcca gctccccagg gcagactcac gtgcccctct gaggctcaga aaatgcccag    660

cccttcctca aaatgagcag ccacccatga ctttgtgggc tccttgttag cctgagacca    720

ggctttgcag aggggcgggg ggtgaggctt agcccagaag gagaactgag caggaaacca    780

aggctcttct ctgtcccctg cccttcccct cctgccaggg ggaggctcag gttggtcccc    840

gagtgccgcc tgccacagca ggacaggccg ggacaggcct cacccaaggc caaggctggc    900

atcagccaat cattcagagc tgaggccctg ggcctagcct gcccttctca ggtgccaata    960

ccaccccagc cctgcccttg gcctcacttt ttcccagcaa taagtggggt tcaccacccg   1020

cctcgggaat actttcccct tctaaatggg acttgctgtt acctcaggag gctccttagt   1080

gcaaatatga ccctggtcag ggctttgcca ccgttgaagc cctgcagaag gtgcaatgta   1140

ggggttctgg ggccacagag gagaggccac ttcccaccag gacccccaac atgaagtcta   1200

ggcctcaggg gctcccgccc ttcttcctcc agcagcggga actgccactg ctctcccagg   1260

ccctgttctg gaggctaacc ttggttcctg gagagtgtgc ccctccaccc tccctccagc   1320

agccctgatc acaccatgag agccaggaac gggtcaccct gctgaagatc actctgtgcc   1380

ctgggggagg agccaagccc tcaccccaca aggggcaggt gggggcttgg ttgctgaccc   1440

ggcccaagtc cccacagagc accttctgta gctccagctt gtctccctgg cttctctttg   1500

aaggagaaaa atgtaaaata tgcactgaga aagccagccc cgcctgctta gtcagccccg   1560

gcagcagggc agccatggga actcaggaaa agcaggaacc ctttccaaaa gcccagagat   1620

gccctgggct cagatctgta attctcccag gagctgtgat agagcaggcc acacaaagtc   1680

cctacgcctc cctgctgcct cccccagatg catgtggtgg catcaccatt ccccaaattg   1740

aatatcagca tgcggcctga ccagggactc tttagatgca tgaatttatt tatatgaagg   1800

ctctcacaga gacacacaca gcacttcagt agcatttgca ttcctggtta aagaatcacc   1860

aatatttaaa ataaaaactt tcctgaaatt gggactgtca tgttatccag aagggctggt   1920

acatccgccc accatgtccc cctgctgggt caggagccaa cacaggaccc tgcgtgtgag   1980

cgtgcctgac atctcacgca cggccactcc agagccggtc cctgtccttg gaaagctgtg   2040

aagccttgcg ttgagttcct tctcgatact gacggctccg tgctgacatt ctgagctctg   2100

gagtcacacc agcgcagggg cgtggaggaa ctgaggtttg gaaggaatgc caggtctcgc   2160

acagcttggc ctcgagaagg tgagaggaag gcaaaggcca gggaggggac ccagagaggc   2220

ctggcacaca aggcccaagc accaccgtca acacagccca gtccatacag aaatgggttt   2280

catgcctgaa aagcttttta cagaaagatg ccgcctgtag ccagtgacag ccgcaaccct   2340

acaggcctca gttccttgca gaggtgaggg gtagagagtc agcctccctc ccttccagca   2400

gcgacccagc ttccctccac ttccaggtgg tgctgggctc accgagggag cactggtggg   2460

tgctctgaaa acccacagga tcccacctcc aggcccacct gggtcccatc tcactctctt   2520

cttctttcac caattgctaa catagacctt gttgggatca cgatggcttc acaagccagc   2580

tgttgggttt gctatgtcac tgtggctcag tcacatccct gcgtgtatac tgtctgcggg   2640

gcacatatgt atccatttag agctaaagga atcagtgtac actacagcta atcctaataa   2700

atccgatgtt ttcggaatgg cgtc                                          2724


<210>  9772
<211>  63
<212>  PRT
<213>  Homosapiens

<400>  9772

Met Ser Thr Glu Asn Lys Ala Lys Pro Leu Pro Cys Leu Ser Gln Leu 
1               5                   10                  15      


Pro Gln Gly Phe Gln Glu Phe Leu Val Phe Pro Gly His Gln Thr Ala 
            20                  25                  30          


Ile Thr Gly Gly Ala Ser Phe Leu Pro Thr Leu Arg Ser Arg Pro Ser 
        35                  40                  45              


Ala Leu Ser Asp Gln Pro Pro Leu Gly Gly Leu Pro Leu Ala Val 
    50                  55                  60              


<210>  9773
<211>  7788
<212>  DNA
<213>  Homosapiens

<400>  9773
gcggttccat cttcctggga agacagggag ttacagatcg ttttaaggga atcccaggac     60

tctagaagtc tccttcatgg gtttctcttt ctgcaccttt cctgtgaatg gtgtatccac    120

ccgggtcccc tcctgcctct ttgcacactc tctgtggtgt aacttgcacc cagggcttca    180

gcagccatct atgcactgag acctttctgt tcttggggtg gcattcctcg ggatttagtg    240

ccaggacaca cctgtgtgcg cattcactgg gaaaagtctg cagaatctac accaggcctt    300

cctggagggc gtgttcctcc atctacattc gtgatggaac aaccagttat tgtcgccggg    360

acaccagtgc ctcatgcaca ccatcagcca cgggagtttt actgttacaa gcttgtcctc    420

ttaggcacat tccctcatcc tgaacctgct ggcagcagct cctttagggg agcgagggtg    480

gctgcttgtc ccttccgtcc ttgggcagcc agcgctcagc tggatgcatg cagtggaagt    540

caccttctgc ctccactcct gagcaggatg tgctctcccc acatctcctg tttgcgcttt    600

cagcaataga tcattcacag ccataggacg gggaggcctc ccagtccttg gctttttgta    660

cctggaaggg gatggtgagg cgttcagctg ccaggaatca cttccttccc tccagggacc    720

agccccttgc attgttcatt ttctaaagca aatacttctc aggaagtggc tctcctcttt    780

tttttttttt cctacgaagc tcttttctta aaagcttact ttaactgcaa aaagttccac    840

tgttcatgga ggaagaaaat caggcttgct gggtgagacg acagaatagg gcttgctgta    900

attctctcct ggaggcaggc tctctctctg gctctctgtt cccccttccc caacctctgt    960

gaaaccactt caaggatggc tcaagctgcg ctgatccttg aggcgccaac agcctaagct   1020

gtcagcatct tctccagagc ctggaagtag aggccttgtc actttttggt ataaaagttt   1080

tgggttaaga ggtgccagca gcagaaacat atgttcaagg atgaaggtaa gtctgtcttc   1140

acaaatgact gatcctgaag atggactggc acctccaggc ccaggtccct gcagaatcag   1200

gtgatgggtc cccaaaacac aaatggtggc acaatgagaa atctggtggt gggcttggac   1260

gaaatggtgt ggatgctggg tggtctcttg ctttcacctc tgtggcaggc actgctgagg   1320

tgctgggtcc ctgggccttt tcttggctct gagccatctg gtcagggaat gggtaggaag   1380

ctggcttaca taaaacagtc atgtccctga gaaggctgtg tgggccccag caggcaggtg   1440

ggttgacctg ggagcagcgc ctgcaaggct ggcacttgca caccatcccg ttacacagag   1500

ccttcctgcg gttcctgagt gtggtgggga tcctcccgcc acagctggca gccccatgtc   1560

tcctctggct gcacacagga tcactaggga actttaaaaa ggcactgatg ccagggctcc   1620

acttcggcca atacaatcag tctctcaggg cagcactggg aggaggtgtt tgtggtgttt   1680

catggacaca cacactgcca gcatcaggga gtagtgacag ggtactgaga acagcagaat   1740

atctagaagt gagttcttca taactgtgga acacagaagt cttccctcac agtgtggccc   1800

ttgcccactg ctgctggagg agagcgctaa ggccctggaa cactcgtcct tacacagcca   1860

gagtctagtg aaggccacag agccacagcc cactgccttt atgcactgat ccactccatt   1920

ttctcatttt tagattgttt taacctttga aagcacagat cccaatgcag acgagctccc   1980

aattcttgga gttcacagac atttgatccg tgtttgaaaa taccccagtc cttgtgcaga   2040

gttcccagaa ttccaagttt tcctttccca ggctcgttct tggagctggc ccatgatact   2100

agctggactc ttgaacattc ctgacccatc acggccaccc ttcgaggctt ccgattatgc   2160

agacacacca tgcccctgca cagtgctcaa agtcaggctg ccgcatgctt ctatactaga   2220

cagtcaaagt cggagcccag ggctcagcaa agcacctggc acagtggcgg ctgcagaatg   2280

agatctgctt gcctggatgc caaggctgga gggcagtaag cttcggtatc ctcagaggca   2340

gggggctgcc acctttgcac taagaaggaa ttactgattt ctaccatttg agaaaaggag   2400

tgttgaccac atggaactcc gaataggttc atgcacatgg aacaaagccc tttaggagaa   2460

aagcccgttt tttgctgtct gcctgatact ggatggttga gaaacaatcg tggtgggcag   2520

tcacgccaca cttgtgcggg cctaggacac aggaaggttt agccctggcc tacagggagg   2580

gtgggcaagc acagcaatct tgtcccccaa aagaacatca gtggccgctg gtgccaagac   2640

ccacgggaag gttagagctc tgggttacat ttgtggagag agacacagac agcggcagag   2700

acagagacgt agtaatccag gctgtgtggc ataagaagat aaagcggccc cccagcccgg   2760

ggcccctccc atggacctca tggtaccgag cctccatttt ctcatctgtt cagtgaggat   2820

gaagcctcat ctcccagggt ttttgcaaag acagggagac tggccgggcg ccgtggctta   2880

cgcctataat cccagcacct tgggaggccg aggcaggcgg atcacaaggt caggagtttg   2940

agaccagcct aaccaacatg gtgaaacccc gtctctacta aaaatacaaa aattaggcag   3000

gcgtggtggc acgcgcctgt aatcccagct actcaggagg ctgaggcagg agaatcactt   3060

gaacccagga ggcagaggtt gcagtgagcc gagattgcgc cactgcactc cagcctgggt   3120

gacagagcaa gactctcaaa aaaaaaaaaa aaaagatagg gaaactgtgc ccaatgcacc   3180

agaaggtggt tcctcggtgc ctgtgagtgc ccttgccctc tgccaagggt actgagctac   3240

gtgccctgtg cccttgatgt acactgagaa ttcactgctt gccaccttcc gtccaattct   3300

aatttcagca tttcacagct cacttttgaa atagcatctt tcatccccaa atgtctgtgc   3360

acattgcaga aatgaaaaca gcccctctct gaaggcagaa gtgtgagatc cgggttctct   3420

gttttcctgg gaaaacaaga gatccagaag gagagatggg ggagggggtg ggaaggtttg   3480

ggcctcaatc aggctcaagt tcaatgagca tgtgttaagc tcctgctgtg ttccctgggc   3540

ttttgcacac agggtgttat tcaccttccc cgtggtcctc tgggggaggg tcaaggtccc   3600

actggcagct gaggaaacgg aggctcagcg atgtggaaat cccagcccat gttcacgagg   3660

cagcagagct aggaatcaaa cccagcaatc cttccctctg ccacacagcc tcctcatcga   3720

gctggtgcta tttctacttc cacccgagag aaatggacgc acactttctc tgtgtggctc   3780

ctgtgggccc ttccgcactg ccctgcttcg tgctcagttg atctgtgtga ttctgcacct   3840

gccgtgtatt ttcagtaccc cagagaaatg gccagagctc atcccaggca actcttgcca   3900

gtgatgcaaa attacaaccc atgagcgatc atggggaggg tatagagcgg gcaaaattca   3960

gacgtgactt cccaccttgg gcgcagcggc tgcctggcca gctcccccaa ggtggagcag   4020

agccaggctg aatagaggct gagtcagaag ggagagtcct tgggcatgca ggcttaagga   4080

cgcaggcttg ggagacgaac ctggctgatg ttcagtttgg gcatcactct ccttaatgta   4140

ctgtaaactg tcactgcgga agagccgggt gtggatgcca cttgtgctca cagcccttgt   4200

tttccctccc cggctaggtc cttgctgcga aagtgctcaa ccttgtgctg ccaaacttgt   4260

ccctcgggcc catcgactcc agcgtgctct ctcggaataa gacagaggtc gacatttata   4320

actcagaccc cctgatctgc cgggcagggc tgaaggtgtg cttcggcatc caactgctga   4380

atgccgtctc acgggtggag cgcgccctcc ccaagctgac tgtgcccttc ctgctgctcc   4440

agggctctgc cgatcgccta tgtgacagca aaggggccta cctgctcatg gagttagcca   4500

agagccagga caagactctc aagatttatg aaggtgccta ccatgttctc cacaaggagc   4560

ttcctgaagt caccaactcc gtcttccatg aaataaacat gtgggtctct caaaggacag   4620

ccacggcagg aactgcgtcc ccaccctgaa tgcattggcc ggtgcccggc tcatggtctg   4680

ggggatgcag gcaggggaag ggcagagatg gcttctcaga tatggcttgc caaaaaaaaa   4740

aaaaaaaaaa aatcagaaat tggagaaatc cttagcacaa ttttctaaaa aataacagac   4800

atttttgtta tacattagac tatcagacac tggacctacc ttaatggtta gacactttat   4860

gcaaaaaaag agaaaggtcc caggtgattt tccacaaaga atgtgctaaa atgtccactg   4920

aaaacaaagc caagcctctg ccctgcctct cccagctccc acaagggttc caggaattcc   4980

tggtgttccc aggacaccag actgcaataa ctggaggcgc ctccttcctg cccacccttc   5040

gctcacgccc cagcgccctc tctgaccagc ctccgcttgg tggccttcct ctggccgtgt   5100

gatgaggtgg ttgctgtctc cataggggcc agctccccag ggcagactca cgtgcccctc   5160

tgaggctcag aaaatgccca gcccttcctc aaaatgagca gccacccatg actttgtggg   5220

ctccttgtta gcctgagacc aggctttgca gaggggcggg gggtgaggct tagcccagaa   5280

ggagaactga gcaggaaacc aaggctcttc tctgtcccct gcccttcccc tcctgccagg   5340

gggaggctca ggttggtccc cgagtgccgc ctgtactcac aaaggctgcc tttcctctag   5400

agtcactaat tttacctgat gctatgagag aatcatattg aagatgaaat gtctaatata   5460

taatgtatat tttaaagcag agactatttt ggtggatagg tgggagggag caaggggagt   5520

ttgagggaat cagagcttga tgctactgta cagaactgga caggttgggc cggcagtggt   5580

ggggccagag ggctctgtgc tctaggagct aagccagcag cccccgagag gggacttggc   5640

tgggcctttc ctatgggcaa ggcccagtgc tcttcctgcc caccagggac catggagcag   5700

tggcacccta tggggctatg atccctaggc ctgggcctgg gcctgcctat ggcccagagc   5760

taccctggga gtgtcagtgc tagcagcaca gctacctctg gtggcaggag aagagaggcc   5820

cagcacagca gcaggccagg ccttcctgtc caggtctgca tggagcactc ggtgacccag   5880

agcagggact ggaggcaccc ccagccctgc cccaggccac agcaggacag gccgggacag   5940

gcctcaccca aggccaaggc tggcatcagc caatcattca gagctgaggc cctgggccta   6000

gcctgccctt ctcaggtgcc aataccaccc cagccctgcc cttggcctca ctttttccca   6060

gcaataagtg gggttcacca cccgcctcgg gaatactttc cccttctaaa tgggacttgc   6120

tgttacctca ggaggctcct tagtgcaaat atgaccctgg tcagggcttt gccaccgttg   6180

aagccctgca gaaggtgcaa tgtaggggtt ctggggccac agaggagagg ccacttccca   6240

ccaggacccc caacatgaag tctaggcctc aggggctccc gcccttcttc ctccagcagc   6300

gggaactgcc actgctctcc caggccctgt tctggaggct aaccttggtt cctggagagt   6360

gtgcccctcc accctccctc cagcagccct gatcacacca tgagagccag gaacgggtca   6420

ccctgctgaa gatcactctg tgccctgggg gaggagccaa gccctcaccc cacaaggggc   6480

aggtgggggc ttggttgctg acccggccca agtccccaca gagcaccttc tgtagctcca   6540

gcttgtctcc ctggcttctc tttgaaggag aaaaatgtaa aatatgcact gagaaagcca   6600

gccccgcctg cttagtcagc cccggcagca gggcagccat gggaactcag gaaaagcagg   6660

aaccctttcc aaaagcccag agatgccctg ggctcagatc tgtaattctc ccaggagctg   6720

tgatagagca ggccacacaa agtccctacg cctccctgct gcctccccca gatgcatgtg   6780

gtggcatcac cattccccaa attgaatatc agcatgcggc ctgaccaggg actctttaga   6840

tgcatgaatt tatttatatg aaggctctca cagagacaca cacagcactt cagtagcatt   6900

tgcattcctg gttaaagaat caccaatatt taaaataaaa actttcctga aattgggact   6960

gtcatgttat ccagaagggc tggtacatcc gcccaccatg tccccctgct gggtcaggag   7020

ccaacacagg accctgcgtg tgagcgtgcc tgacatctca cgcacggcca ctccagagcc   7080

ggtccctgtc cttggaaagc tgtgaagcct tgcgttgagt tccttctcga tactgacggc   7140

tccgtgctga cattctgagc tctggagtca caccagcgca ggggcgtgga ggaactgagg   7200

tttggaagga atgccaggtc tcgcacagct tggcctcgag aaggtgagag gaaggcaaag   7260

gccagggagg ggacccagag aggcctggca cacaaggccc aagcaccacc gtcaacacag   7320

cccagtccat acagaaatgg gtttcatgcc tgaaaagctt tttacagaaa gatgccgcct   7380

gtagccagtg acagccgcaa ccctacaggc ctcagttcct tgcagaggtg aggggtagag   7440

agtcagcctc cctcccttcc agcagcgacc cagcttccct ccacttccag gtggtgctgg   7500

gctcaccgag ggagcactgg tgggtgctct gaaaacccac aggatcccac ctccaggccc   7560

acctgggtcc catctcactc tcttcttctt tcaccaattg ctaacataga ccttgttggg   7620

atcacgatgg cttcacaagc cagctgttgg gtttgctatg tcactgtggc tcagtcacat   7680

ccctgcgtgt atactgtctg cggggcacat atgtatccat ttagagctaa aggaatcagt   7740

gtacactaca gctaatccta ataaatccga tgttttcgga atggcgtc                7788


<210>  9774
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  9774

Met Glu Leu Ala Lys Ser Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly 
1               5                   10                  15      


Ala Tyr His Val Leu His Lys Glu Leu Pro Glu Val Thr Asn Ser Val 
            20                  25                  30          


Phe His Glu Ile Asn Met Trp Val Ser Gln Arg Thr Ala Thr Ala Gly 
        35                  40                  45              


Thr Ala Ser Pro Pro 
    50              


<210>  9775
<211>  2874
<212>  DNA
<213>  Homosapiens

<400>  9775
aggacctgaa gacccttcca gcatgccaga ggaaagttcc cccaggcgga ccccgcagag     60

aattcctggt gttcccagga caccagactg caataactgg aggcgcctcc ttcctgccca    120

cccttcgctc acgccccagc gccctctctg accagcctcc gcttggtggc cttcctctgg    180

ccgtgtgatg aggtggttgc tgtctccata ggggccagct ccccagggca gactcacgtg    240

cccctctgag gctcagaaaa tgcccagccc ttcctcaaaa tgagcagcca cccatgactt    300

tgtgggctcc ttgttagcct gagaccaggc tttgcagagg ggcggggggt gaggcttagc    360

ccagaaggag aactgagcag gaaaccaagg ctcttctctg tcccctgccc ttcccctcct    420

gccaggggga ggctcaggtt ggtccccgag tgccgcctgt actcacaaag gctgcctttc    480

ctctagagtc actaatttta cctgatgcta tgagagaatc atattgaaga tgaaatgtct    540

aatatataat gtatatttta aagcagagac tattttggtg gataggtggg agggagcaag    600

gggagtttga gggaatcaga gcttgatgct actgtacaga actggacagg ttgggccggc    660

agtggtgggg ccagagggct ctgtgctcta ggagctaagc cagcagcccc cgagagggga    720

cttggctggg cctttcctat gggcaaggcc cagtgctctt cctgcccacc agggaccatg    780

gagcagtggc accctatggg gctatgatcc ctaggcctgg gcctgggcct gcctatggcc    840

cagagctacc ctgggagtgt cagtgctagc agcacagcta cctctggtgg caggagaaga    900

gaggcccagc acagcagcag gccaggcctt cctgtccagg tctgcatgga gcactcggtg    960

acccagagca gggactggag gcacccccag ccctgcccca ggccacagca ggacaggccg   1020

ggacaggcct cacccaaggc caaggctggc atcagccaat cattcagagc tgaggccctg   1080

ggcctagcct gcccttctca ggtgccaata ccaccccagc cctgcccttg gcctcacttt   1140

ttcccagcaa taagtggggt tcaccacccg cctcgggaat actttcccct tctaaatggg   1200

acttgctgtt acctcaggag gctccttagt gcaaatatga ccctggtcag ggctttgcca   1260

ccgttgaagc cctgcagaag gtgcaatgta ggggttctgg ggccacagag gagaggccac   1320

ttcccaccag gacccccaac atgaagtcta ggcctcaggg gctcccgccc ttcttcctcc   1380

agcagcggga actgccactg ctctcccagg ccctgttctg gaggctaacc ttggttcctg   1440

gagagtgtgc ccctccaccc tccctccagc agccctgatc acaccatgag agccaggaac   1500

gggtcaccct gctgaagatc actctgtgcc ctgggggagg agccaagccc tcaccccaca   1560

aggggcaggt gggggcttgg ttgctgaccc ggcccaagtc cccacagagc accttctgta   1620

gctccagctt gtctccctgg cttctctttg aaggagaaaa atgtaaaata tgcactgaga   1680

aagccagccc cgcctgctta gtcagccccg gcagcagggc agccatggga actcaggaaa   1740

agcaggaacc ctttccaaaa gcccagagat gccctgggct cagatctgta attctcccag   1800

gagctgtgat agagcaggcc acacaaagtc cctacgcctc cctgctgcct cccccagatg   1860

catgtggtgg catcaccatt ccccaaattg aatatcagca tgcggcctga ccagggactc   1920

tttagatgca tgaatttatt tatatgaagg ctctcacaga gacacacaca gcacttcagt   1980

agcatttgca ttcctggtta aagaatcacc aatatttaaa ataaaaactt tcctgaaatt   2040

gggactgtca tgttatccag aagggctggt acatccgccc accatgtccc cctgctgggt   2100

caggagccaa cacaggaccc tgcgtgtgag cgtgcctgac atctcacgca cggccactcc   2160

agagccggtc cctgtccttg gaaagctgtg aagccttgcg ttgagttcct tctcgatact   2220

gacggctccg tgctgacatt ctgagctctg gagtcacacc agcgcagggg cgtggaggaa   2280

ctgaggtttg gaaggaatgc caggtctcgc acagcttggc ctcgagaagg tgagaggaag   2340

gcaaaggcca gggaggggac ccagagaggc ctggcacaca aggcccaagc accaccgtca   2400

acacagccca gtccatacag aaatgggttt catgcctgaa aagcttttta cagaaagatg   2460

ccgcctgtag ccagtgacag ccgcaaccct acaggcctca gttccttgca gaggtgaggg   2520

gtagagagtc agcctccctc ccttccagca gcgacccagc ttccctccac ttccaggtgg   2580

tgctgggctc accgagggag cactggtggg tgctctgaaa acccacagga tcccacctcc   2640

aggcccacct gggtcccatc tcactctctt cttctttcac caattgctaa catagacctt   2700

gttgggatca cgatggcttc acaagccagc tgttgggttt gctatgtcac tgtggctcag   2760

tcacatccct gcgtgtatac tgtctgcggg gcacatatgt atccatttag agctaaagga   2820

atcagtgtac actacagcta atcctaataa atccgatgtt ttcggaatgg cgtc         2874


<210>  9776
<211>  42
<212>  PRT
<213>  Homosapiens

<400>  9776

Met Pro Glu Glu Ser Ser Pro Arg Arg Thr Pro Gln Arg Ile Pro Gly 
1               5                   10                  15      


Val Pro Arg Thr Pro Asp Cys Asn Asn Trp Arg Arg Leu Leu Pro Ala 
            20                  25                  30          


His Pro Ser Leu Thr Pro Gln Arg Pro Leu 
        35                  40          


<210>  9777
<211>  4948
<212>  DNA
<213>  Homosapiens

<400>  9777
gtcgccgcga agccggtcgc gcgcagctcg tcccggccct ggcccgccgc aaacgaggat     60

ccgctgcgct cggggaacgc gacagcggcg ctcgtggccc cggtaactgc ctcccggccc    120

ctgccccagc ccgccagtgc cgccgtcagg ggtggggagc agcactgggg tcccggacac    180

gcccggcgtg ggctcccgct acccatgtgt gcgtgtgtgt gtgtgcacgg tgtgtgtgcg    240

cgcgtgtccg agtgtgcgcg cgtgtgcgcg cgcgcgcgcc ctccctgctc cttcgcacca    300

gcccccaaac caacttgtcc ccatcaactc catctttcta gtccccacct tccccggtgc    360

agacacccgg cgaagcccac ccggttttcc cagcggcatt tccgatgaca gcttcggggc    420

tacgtgtcct gtgctgtcgg agacgcacag gaagcaaagt ttgtgagaag ccttgggggc    480

gactttgcct tgggcacccg catttgtgcg tctgcgaggt gcctcggtgt gcgcggagct    540

agtttcccag tttcccgggc ccctcccttc tccgagcccc tctagcgatt tgtttaggaa    600

aagtgatgac atgaactagt agtggagaat cgcagcgccg ctccccgccc tggggaggga    660

ggggagcccc ggagagcctg ccggtgggag ctggaagcag gctcccggct gagcgcccca    720

gcccgaaagg cagggtctgg gtgcgggaag agggctcgga gctgccttcc tgctgccttg    780

gggccgccca gatgagggaa cagcccgatt tgcctggttc tgattctcca ggctgtcgtg    840

gttgtggaat gcaaacgcca gcacataatg gaaacaggac ctgaagaccc ttccagcatg    900

ccagaggaaa gttcccccag gcggaccccg cagagcattc cctaccagga cctccctcac    960

ctggtcaatg cagacggaca gtacctcttc tgcaggtact ggaaacccac aggcacaccc   1020

aaggccctca tctttgtgtc ccatggagcc ggagagcaca gtggccgcta tgaagagctg   1080

gctcggatgc tgatggggct ggacctgctg gtgttcgccc acgaccatgt tggccacgga   1140

cagagcgaag gggagaggat ggtagtgtct gacttccacg ttttcgtcag ggatgtgttg   1200

cagcatgtgg attccatgca gaaagactac cctgggcttc ctgtcttcct tctgggccac   1260

tccatgggag gcgccatcgc catcctcacg gccgcagaga ggccgggcca cttcgccggc   1320

atggtactca tttcgcctct ggttcttgcc aatcctgaat ctgcaacaac tttcaaggtc   1380

cttgctgcga aagtgctcaa ccttgtgctg ccaaacttgt ccctcgggcc catcgactcc   1440

agcgtgctct ctcggaataa gacagaggtc gacatttata actcagaccc cctgatctgc   1500

cgggcagggc tgaaggtgtg cttcggcatc caactgctga atgccgtctc acgggtggag   1560

cgcgccctcc ccaagctgac tgtgcccttc ctgctgctcc agggctctgc cgatcgccta   1620

tgtgacagca aaggggccta cctgctcatg gagttagcca agagccagga caagactctc   1680

aagatttatg aaggtgccta ccatgttctc cacaaggagc ttcctgaagt caccaactcc   1740

gtcttccatg aaataaacat gtgggtctct caaaggacag ccacggcagg aactgcgtcc   1800

ccaccctgaa tgcattggcc ggtgcccggc tcatggtctg ggggatgcag gcaggggaag   1860

ggcagagatg gcttctcaga tatggcttgc caaaaaaaaa aaaaaaaaaa aatcagaaat   1920

tggagaaatc cttagcacaa ttttctaaaa aataacagac atttttgtta tacattagac   1980

tatcagacac tggacctacc ttaatggtta gacactttat gcaaaaaaag agaaaggtcc   2040

caggtgattt tccacaaaga atgtgctaaa atgtccactg aaaacaaagc caagcctctg   2100

ccctgcctct cccagctccc acaagggttc caggaattcc tggtgttccc aggacaccag   2160

actgcaataa ctggaggcgc ctccttcctg cccacccttc gctcacgccc cagcgccctc   2220

tctgaccagc ctccgcttgg tggccttcct ctggccgtgt gatgaggtgg ttgctgtctc   2280

cataggggcc agctccccag ggcagactca cgtgcccctc tgaggctcag aaaatgccca   2340

gcccttcctc aaaatgagca gccacccatg actttgtggg ctccttgtta gcctgagacc   2400

aggctttgca gaggggcggg gggtgaggct tagcccagaa ggagaactga gcaggaaacc   2460

aaggctcttc tctgtcccct gcccttcccc tcctgccagg gggaggctca ggttggtccc   2520

cgagtgccgc ctgtactcac aaaggctgcc tttcctctag agtcactaat tttacctgat   2580

gctatgagag aatcatattg aagatgaaat gtctaatata taatgtatat tttaaagcag   2640

agactatttt ggtggatagg tgggagggag caaggggagt ttgagggaat cagagcttga   2700

tgctactgta cagaactgga caggttgggc cggcagtggt ggggccagag ggctctgtgc   2760

tctaggagct aagccagcag cccccgagag gggacttggc tgggcctttc ctatgggcaa   2820

ggcccagtgc tcttcctgcc caccagggac catggagcag tggcacccta tggggctatg   2880

atccctaggc ctgggcctgg gcctgcctat ggcccagagc taccctggga gtgtcagtgc   2940

tagcagcaca gctacctctg gtggcaggag aagagaggcc cagcacagca gcaggccagg   3000

ccttcctgtc caggtctgca tggagcactc ggtgacccag agcagggact ggaggcaccc   3060

ccagccctgc cccaggccac agcaggacag gccgggacag gcctcaccca aggccaaggc   3120

tggcatcagc caatcattca gagctgaggc cctgggccta gcctgccctt ctcaggtgcc   3180

aataccaccc cagccctgcc cttggcctca ctttttccca gcaataagtg gggttcacca   3240

cccgcctcgg gaatactttc cccttctaaa tgggacttgc tgttacctca ggaggctcct   3300

tagtgcaaat atgaccctgg tcagggcttt gccaccgttg aagccctgca gaaggtgcaa   3360

tgtaggggtt ctggggccac agaggagagg ccacttccca ccaggacccc caacatgaag   3420

tctaggcctc aggggctccc gcccttcttc ctccagcagc gggaactgcc actgctctcc   3480

caggccctgt tctggaggct aaccttggtt cctggagagt gtgcccctcc accctccctc   3540

cagcagccct gatcacacca tgagagccag gaacgggtca ccctgctgaa gatcactctg   3600

tgccctgggg gaggagccaa gccctcaccc cacaaggggc aggtgggggc ttggttgctg   3660

acccggccca agtccccaca gagcaccttc tgtagctcca gcttgtctcc ctggcttctc   3720

tttgaaggag aaaaatgtaa aatatgcact gagaaagcca gccccgcctg cttagtcagc   3780

cccggcagca gggcagccat gggaactcag gaaaagcagg aaccctttcc aaaagcccag   3840

agatgccctg ggctcagatc tgtaattctc ccaggagctg tgatagagca ggccacacaa   3900

agtccctacg cctccctgct gcctccccca gatgcatgtg gtggcatcac cattccccaa   3960

attgaatatc agcatgcggc ctgaccaggg actctttaga tgcatgaatt tatttatatg   4020

aaggctctca cagagacaca cacagcactt cagtagcatt tgcattcctg gttaaagaat   4080

caccaatatt taaaataaaa actttcctga aattgggact gtcatgttat ccagaagggc   4140

tggtacatcc gcccaccatg tccccctgct gggtcaggag ccaacacagg accctgcgtg   4200

tgagcgtgcc tgacatctca cgcacggcca ctccagagcc ggtccctgtc cttggaaagc   4260

tgtgaagcct tgcgttgagt tccttctcga tactgacggc tccgtgctga cattctgagc   4320

tctggagtca caccagcgca ggggcgtgga ggaactgagg tttggaagga atgccaggtc   4380

tcgcacagct tggcctcgag aaggtgagag gaaggcaaag gccagggagg ggacccagag   4440

aggcctggca cacaaggccc aagcaccacc gtcaacacag cccagtccat acagaaatgg   4500

gtttcatgcc tgaaaagctt tttacagaaa gatgccgcct gtagccagtg acagccgcaa   4560

ccctacaggc ctcagttcct tgcagaggtg aggggtagag agtcagcctc cctcccttcc   4620

agcagcgacc cagcttccct ccacttccag gtggtgctgg gctcaccgag ggagcactgg   4680

tgggtgctct gaaaacccac aggatcccac ctccaggccc acctgggtcc catctcactc   4740

tcttcttctt tcaccaattg ctaacataga ccttgttggg atcacgatgg cttcacaagc   4800

cagctgttgg gtttgctatg tcactgtggc tcagtcacat ccctgcgtgt atactgtctg   4860

cggggcacat atgtatccat ttagagctaa aggaatcagt gtacactaca gctaatccta   4920

ataaatccga tgttttcgga atggcgtc                                      4948


<210>  9778
<211>  313
<212>  PRT
<213>  Homosapiens

<400>  9778

Met Glu Thr Gly Pro Glu Asp Pro Ser Ser Met Pro Glu Glu Ser Ser 
1               5                   10                  15      


Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr Gln Asp Leu Pro His Leu 
            20                  25                  30          


Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys Arg Tyr Trp Lys Pro Thr 
        35                  40                  45              


Gly Thr Pro Lys Ala Leu Ile Phe Val Ser His Gly Ala Gly Glu His 
    50                  55                  60                  


Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met Leu Met Gly Leu Asp Leu 
65                  70                  75                  80  


Leu Val Phe Ala His Asp His Val Gly His Gly Gln Ser Glu Gly Glu 
                85                  90                  95      


Arg Met Val Val Ser Asp Phe His Val Phe Val Arg Asp Val Leu Gln 
            100                 105                 110         


His Val Asp Ser Met Gln Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu 
        115                 120                 125             


Leu Gly His Ser Met Gly Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu 
    130                 135                 140                 


Arg Pro Gly His Phe Ala Gly Met Val Leu Ile Ser Pro Leu Val Leu 
145                 150                 155                 160 


Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys Val Leu Ala Ala Lys Val 
                165                 170                 175     


Leu Asn Leu Val Leu Pro Asn Leu Ser Leu Gly Pro Ile Asp Ser Ser 
            180                 185                 190         


Val Leu Ser Arg Asn Lys Thr Glu Val Asp Ile Tyr Asn Ser Asp Pro 
        195                 200                 205             


Leu Ile Cys Arg Ala Gly Leu Lys Val Cys Phe Gly Ile Gln Leu Leu 
    210                 215                 220                 


Asn Ala Val Ser Arg Val Glu Arg Ala Leu Pro Lys Leu Thr Val Pro 
225                 230                 235                 240 


Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg Leu Cys Asp Ser Lys Gly 
                245                 250                 255     


Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser Gln Asp Lys Thr Leu Lys 
            260                 265                 270         


Ile Tyr Glu Gly Ala Tyr His Val Leu His Lys Glu Leu Pro Glu Val 
        275                 280                 285             


Thr Asn Ser Val Phe His Glu Ile Asn Met Trp Val Ser Gln Arg Thr 
    290                 295                 300                 


Ala Thr Ala Gly Thr Ala Ser Pro Pro 
305                 310             


<210>  9779
<211>  4138
<212>  DNA
<213>  Homosapiens

<400>  9779
gcccccgccg ccgagccggc ccagggataa agtggcggcg cagacgccgc accctgtcgc     60

cgcgaagccg gtcgcgcgca gctcgtcccg gccctggccc gccgcaaacg aggatccgct    120

gcgctcgggg aacgcgacag cggcgctcgt ggccccggac ctgaagaccc ttccagcatg    180

ccagaggaaa gttcccccag gcggaccccg cagagcattc cctaccagga cctccctcac    240

ctggtcaatg cagacggaca gtacctcttc tgcaggtact ggaaacccac aggcacaccc    300

aaggccctca tctttgtgtc ccatggagcc ggagagcaca gtggccgcta tgaagagctg    360

gctcggatgc tgatggggct ggacctgctg gtgttcgccc acgaccatgt tggccacgga    420

cagagcgaag gggagaggat ggtagtgtct gacttccacg ttttcgtcag ggatgtgttg    480

cagcatgtgg attccatgca gaaagactac cctgggcttc ctgtcttcct tctgggccac    540

tccatgggag gcgccatcgc catcctcacg gccgcagaga ggccgggcca cttcgccggc    600

atggtactca tttcgcctct ggttcttgcc aatcctgaat ctgcaacaac tttcaaggtc    660

gacatttata actcagaccc cctgatctgc cgggcagggc tgaaggtgtg cttcggcatc    720

caactgctga atgccgtctc acgggtggag cgcgccctcc ccaagctgac tgtgcccttc    780

ctgctgctcc agggctctgc cgatcgccta tgtgacagca aaggggccta cctgctcatg    840

gagttagcca agagccagga caagactctc aagatttatg aaggtgccta ccatgttctc    900

cacaaggagc ttcctgaagt caccaactcc gtcttccatg aaataaacat gtgggtctct    960

caaaggacag ccacggcagg aactgcgtcc ccaccctgaa tgcattggcc ggtgcccggc   1020

tcatggtctg ggggatgcag gcaggggaag ggcagagatg gcttctcaga tatggcttgc   1080

caaaaaaaaa aaaaaaaaaa aatcagaaat tggagaaatc cttagcacaa ttttctaaaa   1140

aataacagac atttttgtta tacattagac tatcagacac tggacctacc ttaatggtta   1200

gacactttat gcaaaaaaag agaaaggtcc caggtgattt tccacaaaga atgtgctaaa   1260

atgtccactg aaaacaaagc caagcctctg ccctgcctct cccagctccc acaagggttc   1320

caggaattcc tggtgttccc aggacaccag actgcaataa ctggaggcgc ctccttcctg   1380

cccacccttc gctcacgccc cagcgccctc tctgaccagc ctccgcttgg tggccttcct   1440

ctggccgtgt gatgaggtgg ttgctgtctc cataggggcc agctccccag ggcagactca   1500

cgtgcccctc tgaggctcag aaaatgccca gcccttcctc aaaatgagca gccacccatg   1560

actttgtggg ctccttgtta gcctgagacc aggctttgca gaggggcggg gggtgaggct   1620

tagcccagaa ggagaactga gcaggaaacc aaggctcttc tctgtcccct gcccttcccc   1680

tcctgccagg gggaggctca ggttggtccc cgagtgccgc ctgtactcac aaaggctgcc   1740

tttcctctag agtcactaat tttacctgat gctatgagag aatcatattg aagatgaaat   1800

gtctaatata taatgtatat tttaaagcag agactatttt ggtggatagg tgggagggag   1860

caaggggagt ttgagggaat cagagcttga tgctactgta cagaactgga caggttgggc   1920

cggcagtggt ggggccagag ggctctgtgc tctaggagct aagccagcag cccccgagag   1980

gggacttggc tgggcctttc ctatgggcaa ggcccagtgc tcttcctgcc caccagggac   2040

catggagcag tggcacccta tggggctatg atccctaggc ctgggcctgg gcctgcctat   2100

ggcccagagc taccctggga gtgtcagtgc tagcagcaca gctacctctg gtggcaggag   2160

aagagaggcc cagcacagca gcaggccagg ccttcctgtc caggtctgca tggagcactc   2220

ggtgacccag agcagggact ggaggcaccc ccagccctgc cccaggccac agcaggacag   2280

gccgggacag gcctcaccca aggccaaggc tggcatcagc caatcattca gagctgaggc   2340

cctgggccta gcctgccctt ctcaggtgcc aataccaccc cagccctgcc cttggcctca   2400

ctttttccca gcaataagtg gggttcacca cccgcctcgg gaatactttc cccttctaaa   2460

tgggacttgc tgttacctca ggaggctcct tagtgcaaat atgaccctgg tcagggcttt   2520

gccaccgttg aagccctgca gaaggtgcaa tgtaggggtt ctggggccac agaggagagg   2580

ccacttccca ccaggacccc caacatgaag tctaggcctc aggggctccc gcccttcttc   2640

ctccagcagc gggaactgcc actgctctcc caggccctgt tctggaggct aaccttggtt   2700

cctggagagt gtgcccctcc accctccctc cagcagccct gatcacacca tgagagccag   2760

gaacgggtca ccctgctgaa gatcactctg tgccctgggg gaggagccaa gccctcaccc   2820

cacaaggggc aggtgggggc ttggttgctg acccggccca agtccccaca gagcaccttc   2880

tgtagctcca gcttgtctcc ctggcttctc tttgaaggag aaaaatgtaa aatatgcact   2940

gagaaagcca gccccgcctg cttagtcagc cccggcagca gggcagccat gggaactcag   3000

gaaaagcagg aaccctttcc aaaagcccag agatgccctg ggctcagatc tgtaattctc   3060

ccaggagctg tgatagagca ggccacacaa agtccctacg cctccctgct gcctccccca   3120

gatgcatgtg gtggcatcac cattccccaa attgaatatc agcatgcggc ctgaccaggg   3180

actctttaga tgcatgaatt tatttatatg aaggctctca cagagacaca cacagcactt   3240

cagtagcatt tgcattcctg gttaaagaat caccaatatt taaaataaaa actttcctga   3300

aattgggact gtcatgttat ccagaagggc tggtacatcc gcccaccatg tccccctgct   3360

gggtcaggag ccaacacagg accctgcgtg tgagcgtgcc tgacatctca cgcacggcca   3420

ctccagagcc ggtccctgtc cttggaaagc tgtgaagcct tgcgttgagt tccttctcga   3480

tactgacggc tccgtgctga cattctgagc tctggagtca caccagcgca ggggcgtgga   3540

ggaactgagg tttggaagga atgccaggtc tcgcacagct tggcctcgag aaggtgagag   3600

gaaggcaaag gccagggagg ggacccagag aggcctggca cacaaggccc aagcaccacc   3660

gtcaacacag cccagtccat acagaaatgg gtttcatgcc tgaaaagctt tttacagaaa   3720

gatgccgcct gtagccagtg acagccgcaa ccctacaggc ctcagttcct tgcagaggtg   3780

aggggtagag agtcagcctc cctcccttcc agcagcgacc cagcttccct ccacttccag   3840

gtggtgctgg gctcaccgag ggagcactgg tgggtgctct gaaaacccac aggatcccac   3900

ctccaggccc acctgggtcc catctcactc tcttcttctt tcaccaattg ctaacataga   3960

ccttgttggg atcacgatgg cttcacaagc cagctgttgg gtttgctatg tcactgtggc   4020

tcagtcacat ccctgcgtgt atactgtctg cggggcacat atgtatccat ttagagctaa   4080

aggaatcagt gtacactaca gctaatccta ataaatccga tgttttcgga atggcgtc     4138


<210>  9780
<211>  273
<212>  PRT
<213>  Homosapiens

<400>  9780

Met Pro Glu Glu Ser Ser Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr 
1               5                   10                  15      


Gln Asp Leu Pro His Leu Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys 
            20                  25                  30          


Arg Tyr Trp Lys Pro Thr Gly Thr Pro Lys Ala Leu Ile Phe Val Ser 
        35                  40                  45              


His Gly Ala Gly Glu His Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met 
    50                  55                  60                  


Leu Met Gly Leu Asp Leu Leu Val Phe Ala His Asp His Val Gly His 
65                  70                  75                  80  


Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp Phe His Val Phe 
                85                  90                  95      


Val Arg Asp Val Leu Gln His Val Asp Ser Met Gln Lys Asp Tyr Pro 
            100                 105                 110         


Gly Leu Pro Val Phe Leu Leu Gly His Ser Met Gly Gly Ala Ile Ala 
        115                 120                 125             


Ile Leu Thr Ala Ala Glu Arg Pro Gly His Phe Ala Gly Met Val Leu 
    130                 135                 140                 


Ile Ser Pro Leu Val Leu Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys 
145                 150                 155                 160 


Val Asp Ile Tyr Asn Ser Asp Pro Leu Ile Cys Arg Ala Gly Leu Lys 
                165                 170                 175     


Val Cys Phe Gly Ile Gln Leu Leu Asn Ala Val Ser Arg Val Glu Arg 
            180                 185                 190         


Ala Leu Pro Lys Leu Thr Val Pro Phe Leu Leu Leu Gln Gly Ser Ala 
        195                 200                 205             


Asp Arg Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu Met Glu Leu Ala 
    210                 215                 220                 


Lys Ser Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly Ala Tyr His Val 
225                 230                 235                 240 


Leu His Lys Glu Leu Pro Glu Val Thr Asn Ser Val Phe His Glu Ile 
                245                 250                 255     


Asn Met Trp Val Ser Gln Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro 
            260                 265                 270         


Pro 
    


<210>  9781
<211>  4228
<212>  DNA
<213>  Homosapiens

<400>  9781
gcccccgccg ccgagccggc ccagggataa agtggcggcg cagacgccgc accctgtcgc     60

cgcgaagccg gtcgcgcgca gctcgtcccg gccctggccc gccgcaaacg aggatccgct    120

gcgctcgggg aacgcgacag cggcgctcgt ggccccggac ctgaagaccc ttccagcatg    180

ccagaggaaa gttcccccag gcggaccccg cagagcattc cctaccagga cctccctcac    240

ctggtcaatg cagacggaca gtacctcttc tgcaggtact ggaaacccac aggcacaccc    300

aaggccctca tctttgtgtc ccatggagcc ggagagcaca gtggccgcta tgaagagctg    360

gctcggatgc tgatggggct ggacctgctg gtgttcgccc acgaccatgt tggccacgga    420

cagagcgaag gggagaggat ggtagtgtct gacttccacg ttttcgtcag ggatgtgttg    480

cagcatgtgg attccatgca gaaagactac cctgggcttc ctgtcttcct tctgggccac    540

tccatgggag gcgccatcgc catcctcacg gccgcagaga ggccgggcca cttcgccggc    600

atggtactca tttcgcctct ggttcttgcc aatcctgaat ctgcaacaac tttcaaggtc    660

cttgctgcga aagtgctcaa ccttgtgctg ccaaacttgt ccctcgggcc catcgactcc    720

agcgtgctct ctcggaataa gacagaggtc gacatttata actcagaccc cctgatctgc    780

cgggcagggc tgaaggtgtg cttcggcatc caactgctga atgccgtctc acgggtggag    840

cgcgccctcc ccaagctgac tgtgcccttc ctgctgctcc agggctctgc cgatcgccta    900

tgtgacagca aaggggccta cctgctcatg gagttagcca agagccagga caagactctc    960

aagatttatg aaggtgccta ccatgttctc cacaaggagc ttcctgaagt caccaactcc   1020

gtcttccatg aaataaacat gtgggtctct caaaggacag ccacggcagg aactgcgtcc   1080

ccaccctgaa tgcattggcc ggtgcccggc tcatggtctg ggggatgcag gcaggggaag   1140

ggcagagatg gcttctcaga tatggcttgc caaaaaaaaa aaaaaaaaaa aatcagaaat   1200

tggagaaatc cttagcacaa ttttctaaaa aataacagac atttttgtta tacattagac   1260

tatcagacac tggacctacc ttaatggtta gacactttat gcaaaaaaag agaaaggtcc   1320

caggtgattt tccacaaaga atgtgctaaa atgtccactg aaaacaaagc caagcctctg   1380

ccctgcctct cccagctccc acaagggttc caggaattcc tggtgttccc aggacaccag   1440

actgcaataa ctggaggcgc ctccttcctg cccacccttc gctcacgccc cagcgccctc   1500

tctgaccagc ctccgcttgg tggccttcct ctggccgtgt gatgaggtgg ttgctgtctc   1560

cataggggcc agctccccag ggcagactca cgtgcccctc tgaggctcag aaaatgccca   1620

gcccttcctc aaaatgagca gccacccatg actttgtggg ctccttgtta gcctgagacc   1680

aggctttgca gaggggcggg gggtgaggct tagcccagaa ggagaactga gcaggaaacc   1740

aaggctcttc tctgtcccct gcccttcccc tcctgccagg gggaggctca ggttggtccc   1800

cgagtgccgc ctgtactcac aaaggctgcc tttcctctag agtcactaat tttacctgat   1860

gctatgagag aatcatattg aagatgaaat gtctaatata taatgtatat tttaaagcag   1920

agactatttt ggtggatagg tgggagggag caaggggagt ttgagggaat cagagcttga   1980

tgctactgta cagaactgga caggttgggc cggcagtggt ggggccagag ggctctgtgc   2040

tctaggagct aagccagcag cccccgagag gggacttggc tgggcctttc ctatgggcaa   2100

ggcccagtgc tcttcctgcc caccagggac catggagcag tggcacccta tggggctatg   2160

atccctaggc ctgggcctgg gcctgcctat ggcccagagc taccctggga gtgtcagtgc   2220

tagcagcaca gctacctctg gtggcaggag aagagaggcc cagcacagca gcaggccagg   2280

ccttcctgtc caggtctgca tggagcactc ggtgacccag agcagggact ggaggcaccc   2340

ccagccctgc cccaggccac agcaggacag gccgggacag gcctcaccca aggccaaggc   2400

tggcatcagc caatcattca gagctgaggc cctgggccta gcctgccctt ctcaggtgcc   2460

aataccaccc cagccctgcc cttggcctca ctttttccca gcaataagtg gggttcacca   2520

cccgcctcgg gaatactttc cccttctaaa tgggacttgc tgttacctca ggaggctcct   2580

tagtgcaaat atgaccctgg tcagggcttt gccaccgttg aagccctgca gaaggtgcaa   2640

tgtaggggtt ctggggccac agaggagagg ccacttccca ccaggacccc caacatgaag   2700

tctaggcctc aggggctccc gcccttcttc ctccagcagc gggaactgcc actgctctcc   2760

caggccctgt tctggaggct aaccttggtt cctggagagt gtgcccctcc accctccctc   2820

cagcagccct gatcacacca tgagagccag gaacgggtca ccctgctgaa gatcactctg   2880

tgccctgggg gaggagccaa gccctcaccc cacaaggggc aggtgggggc ttggttgctg   2940

acccggccca agtccccaca gagcaccttc tgtagctcca gcttgtctcc ctggcttctc   3000

tttgaaggag aaaaatgtaa aatatgcact gagaaagcca gccccgcctg cttagtcagc   3060

cccggcagca gggcagccat gggaactcag gaaaagcagg aaccctttcc aaaagcccag   3120

agatgccctg ggctcagatc tgtaattctc ccaggagctg tgatagagca ggccacacaa   3180

agtccctacg cctccctgct gcctccccca gatgcatgtg gtggcatcac cattccccaa   3240

attgaatatc agcatgcggc ctgaccaggg actctttaga tgcatgaatt tatttatatg   3300

aaggctctca cagagacaca cacagcactt cagtagcatt tgcattcctg gttaaagaat   3360

caccaatatt taaaataaaa actttcctga aattgggact gtcatgttat ccagaagggc   3420

tggtacatcc gcccaccatg tccccctgct gggtcaggag ccaacacagg accctgcgtg   3480

tgagcgtgcc tgacatctca cgcacggcca ctccagagcc ggtccctgtc cttggaaagc   3540

tgtgaagcct tgcgttgagt tccttctcga tactgacggc tccgtgctga cattctgagc   3600

tctggagtca caccagcgca ggggcgtgga ggaactgagg tttggaagga atgccaggtc   3660

tcgcacagct tggcctcgag aaggtgagag gaaggcaaag gccagggagg ggacccagag   3720

aggcctggca cacaaggccc aagcaccacc gtcaacacag cccagtccat acagaaatgg   3780

gtttcatgcc tgaaaagctt tttacagaaa gatgccgcct gtagccagtg acagccgcaa   3840

ccctacaggc ctcagttcct tgcagaggtg aggggtagag agtcagcctc cctcccttcc   3900

agcagcgacc cagcttccct ccacttccag gtggtgctgg gctcaccgag ggagcactgg   3960

tgggtgctct gaaaacccac aggatcccac ctccaggccc acctgggtcc catctcactc   4020

tcttcttctt tcaccaattg ctaacataga ccttgttggg atcacgatgg cttcacaagc   4080

cagctgttgg gtttgctatg tcactgtggc tcagtcacat ccctgcgtgt atactgtctg   4140

cggggcacat atgtatccat ttagagctaa aggaatcagt gtacactaca gctaatccta   4200

ataaatccga tgttttcgga atggcgtc                                      4228


<210>  9782
<211>  303
<212>  PRT
<213>  Homosapiens

<400>  9782

Met Pro Glu Glu Ser Ser Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr 
1               5                   10                  15      


Gln Asp Leu Pro His Leu Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys 
            20                  25                  30          


Arg Tyr Trp Lys Pro Thr Gly Thr Pro Lys Ala Leu Ile Phe Val Ser 
        35                  40                  45              


His Gly Ala Gly Glu His Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met 
    50                  55                  60                  


Leu Met Gly Leu Asp Leu Leu Val Phe Ala His Asp His Val Gly His 
65                  70                  75                  80  


Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp Phe His Val Phe 
                85                  90                  95      


Val Arg Asp Val Leu Gln His Val Asp Ser Met Gln Lys Asp Tyr Pro 
            100                 105                 110         


Gly Leu Pro Val Phe Leu Leu Gly His Ser Met Gly Gly Ala Ile Ala 
        115                 120                 125             


Ile Leu Thr Ala Ala Glu Arg Pro Gly His Phe Ala Gly Met Val Leu 
    130                 135                 140                 


Ile Ser Pro Leu Val Leu Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys 
145                 150                 155                 160 


Val Leu Ala Ala Lys Val Leu Asn Leu Val Leu Pro Asn Leu Ser Leu 
                165                 170                 175     


Gly Pro Ile Asp Ser Ser Val Leu Ser Arg Asn Lys Thr Glu Val Asp 
            180                 185                 190         


Ile Tyr Asn Ser Asp Pro Leu Ile Cys Arg Ala Gly Leu Lys Val Cys 
        195                 200                 205             


Phe Gly Ile Gln Leu Leu Asn Ala Val Ser Arg Val Glu Arg Ala Leu 
    210                 215                 220                 


Pro Lys Leu Thr Val Pro Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg 
225                 230                 235                 240 


Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser 
                245                 250                 255     


Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly Ala Tyr His Val Leu His 
            260                 265                 270         


Lys Glu Leu Pro Glu Val Thr Asn Ser Val Phe His Glu Ile Asn Met 
        275                 280                 285             


Trp Val Ser Gln Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro Pro 
    290                 295                 300             


<210>  9783
<211>  1113
<212>  DNA
<213>  Homosapiens

<400>  9783
agccctcacc ccacaagggg caggtggggg cttggttgct gacccggccc aagtccccac     60

agagcacctt ctgtagctcc agcttgtctc cctggcttct ctttgaagga gaaaaatgta    120

aaatatgcac tgagaaagcc agccccgcct gcttagtcag ccccggcagc agggcagcca    180

tgggaactca ggaaaagcag gaaccctttc caaaagccca gagatgccct gggctcagat    240

ctgtaattct cccaggagct gtgatagagc aggccacaca aagtccctac gcctccctgc    300

tgcctccccc agatgcatgt ggtggcatca ccattcccca aattgaatat cagcatgcgg    360

cctgaccagg gactctttag atgcatgaat ttatttatat gaaggctctc acagagacac    420

acacagcact tcagtagcat ttgcattcct ggttaaagaa tcaccaatat ttaaaataaa    480

aactttcctg aaattgggac tgtcatgtta tccagaaggg ctggtacatc cgcccaccat    540

gtccccctgc tgggtcagga gccaacacag gaccctgcgt gtgagcgtgc ctgacatctc    600

acgcacggcc actccagagc cggtccctgt ccttggaaag ctgtgaagcc ttgcgttgag    660

ttccttctcg atactgacgg ctccgtgctg acattctgag ctctggagtc acaccagcgc    720

aggggcgtgg aggaactgag gtttggaagg aatgccaggt ctcgcacagc ttggcctcga    780

gaaggtgaga ggaaggcaaa ggccagggag gggacccaga gaggctgggc tcaccgaggg    840

agcactggtg ggtgctctga aaacccacag gatcccacct ccaggcccac ctgggtccca    900

tctcactctc ttcttctttc accaattgct aacatagacc ttgttgggat cacgatggct    960

tcacaagcca gctgttgggt ttgctatgtc actgtggctc agtcacatcc ctgcgtgtat   1020

actgtctgcg gggcacatat gtatccattt agagctaaag gaatcagtgt acactacagc   1080

taatcctaat aaatccgatg ttttcggaat ggc                                1113


<210>  9784
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  9784

Met Pro Gly Leu Ala Gln Leu Gly Leu Glu Lys Val Arg Gly Arg Gln 
1               5                   10                  15      


Arg Pro Gly Arg Gly Pro Arg Glu Ala Gly Leu Thr Glu Gly Ala Leu 
            20                  25                  30          


Val Gly Ala Leu Lys Thr His Arg Ile Pro Pro Pro Gly Pro Pro Gly 
        35                  40                  45              


Ser His Leu Thr Leu Phe Phe Phe His Gln Leu Leu Thr 
    50                  55                  60      


<210>  9785
<211>  1034
<212>  DNA
<213>  Homosapiens

<400>  9785
agccctcacc ccacaagggg caggtggggg cttggttgct gacccggccc aagtccccac     60

agagcacctt ctgtagctcc agcttgtctc cctggcttct ctttgaagga gaaaaatgta    120

aaatatgcac tgagaaagcc agccccgcct gcttagtcag ccccggcagc agggcagcca    180

tgggaactca ggaaaagcag gaaccctttc caaaagccca gagatgccct gggctcagat    240

ctgtaattct cccaggagct gtgatagagc aggccacaca aagtccctac gcctccctgc    300

tgcctccccc agatgcatgt ggtggcatca ccattcccca aattgaatat cagcatgcgg    360

cctgaccagg gactctttag atgcatgaat ttatttatat gaaggctctc acagagacac    420

acacagcact tcagtagcat ttgcattcct ggttaaagaa tcaccaatat ttaaaataaa    480

aactttcctg aaattgggac tgtcatgtta tccagaaggg ctggtacatc cgcccaccat    540

gtccccctgc tgggtcagga gccaacacag gaccctgcgt gtgagcgtgc ctgacatctc    600

acgcacggcc actccagagc cggtccctgt ccttggaaag ctgtgaagcc ttgcgttgag    660

ttccttctcg atactgacgg ctccgtgctg acattctgag ctctggagtc acaccagcgc    720

aggggcgtgg aggaactgag gtttggaagg aatgccaggt ctcgcacagc ttggcctcga    780

gaaggtgaga ggaaggcaaa ggccagggag gggacccaga gaggcctggc acacaaggcc    840

caagcaccac cgtcaacaca gcccagtcca tacagaaatg ggtttcatgc ctgaaaagct    900

ttttacagaa agatgccgct gtggctcagt cacatccctg cgtgtatact gtctgcgggg    960

cacatatgta tccatttaga gctaaaggaa tcagtgtaca ctacagctaa tcctaataaa   1020

tccgatgttt tcgg                                                     1034


<210>  9786
<211>  75
<212>  PRT
<213>  Homosapiens

<400>  9786

Met Pro Gly Leu Ala Gln Leu Gly Leu Glu Lys Val Arg Gly Arg Gln 
1               5                   10                  15      


Arg Pro Gly Arg Gly Pro Arg Glu Ala Trp His Thr Arg Pro Lys His 
            20                  25                  30          


His Arg Gln His Ser Pro Val His Thr Glu Met Gly Phe Met Pro Glu 
        35                  40                  45              


Lys Leu Phe Thr Glu Arg Cys Arg Cys Gly Ser Val Thr Ser Leu Arg 
    50                  55                  60                  


Val Tyr Cys Leu Arg Gly Thr Tyr Val Ser Ile 
65                  70                  75  


<210>  9787
<211>  1368
<212>  DNA
<213>  Homosapiens

<400>  9787
ccagcaataa gtggggttca ccacccgcct cgggaatact ttccccttct aaatgggact     60

tgctgttacc tcaggaggct ccttagtgca aatatgaccc tggtcagggc tttgccaccg    120

ttgaagccct gcagaaggtg caatgtaggg gttctggggc cacagaggag aggccacttc    180

ccaccaggac ccccaacatg aagtctaggc ctcaggggct cccgcccttc ttcctccagc    240

agcgggaact gccactgctc tcccaggccc tgttctggag gctaaccttg gttcctggag    300

agtgtgcccc tccaccctcc ctccagcagc cctgatcaca ccatgagagc caggaacggg    360

tcaccctgct gaagatcact ctgtgccctg ggggaggagc caagccctca ccccacaagg    420

ggcaggtggg ggcttggttg ctgacccggc ccaagtcccc acagagcacc ttctgtagct    480

ccagcttgtc tccctggctt ctctttgaag gagaaaaatg taaaatatgc actgagaaag    540

ccagccccgc ctgcttagtc agccccggca gcagggcagc catgggaact caggaaaagc    600

aggaaccctt tccaaaagcc cagagatgcc ctgggctcag atctgtaatt ctcccaggag    660

ctgtgataga gcaggccaca caaagtccct acgcctccct gctgcctccc ccagatgcat    720

gtggtggcat caccattccc caaattgaat atcagcatgc ggcctgacca gggactcttt    780

agatgcatga atttatttat atgaaggctc tcacagagac acacacagca cttcagtagc    840

atttgcattc ctggttaaag aatcaccaat atttaaaata aaaactttcc tgaaattggg    900

actgtcatgt tatccagaag ggctggtaca tccgcccacc atgtccccct gctgggtcag    960

gagccaacac aggaccctgc gtgtgagcgt gcctgacatc tcacgcacgg ccactccaga   1020

gccggtccct gtccttggaa agctgtgaag ccttgcgttg agttccttct cgatactgac   1080

ggctccgtgc tgacattctg agctctggag tcacaccagc gcaggggcgt ggaggaactg   1140

aggtttggaa ggaatgccag gtctcactct cttcttcttt caccaattgc taacatagac   1200

cttgttggga tcacgatggc ttcacaagcc agctgttggg tttgctatgt cactgtggct   1260

cagtcacatc cctgcgtgta tactgtctgc ggggcacata tgtatccatt tagagctaaa   1320

ggaatcagtg tacactacag ctaatcctaa taaatccgat gttttcgg                1368


<210>  9788
<211>  61
<212>  PRT
<213>  Homosapiens

<400>  9788

Met Gly Thr Gln Glu Lys Gln Glu Pro Phe Pro Lys Ala Gln Arg Cys 
1               5                   10                  15      


Pro Gly Leu Arg Ser Val Ile Leu Pro Gly Ala Val Ile Glu Gln Ala 
            20                  25                  30          


Thr Gln Ser Pro Tyr Ala Ser Leu Leu Pro Pro Pro Asp Ala Cys Gly 
        35                  40                  45              


Gly Ile Thr Ile Pro Gln Ile Glu Tyr Gln His Ala Ala 
    50                  55                  60      


<210>  9789
<211>  1293
<212>  DNA
<213>  Homosapiens

<400>  9789
gcccagtgct cttcctgccc accagggacc atggagcagt ggcaccctat ggggctatga     60

tccctaggcc tgggcctggg cctgcctatg gcccagagct accctgggag tgtcagtgct    120

agcagcacag ctacctctgg tggcaggaga agagaggccc agcacagcag caggccaggc    180

cttcctgtcc aggtctgcat ggagcactcg gtgacccaga gcagggactg gaggcacccc    240

cagccctgcc ccaggccaca gcaggacagg ccgggacagg cctcacccaa ggccaaggct    300

ggcatcagcc aatcattcag agctgaggcc ctgggcctag cctgcccttc tcaggtgcca    360

ataccacccc agccctgccc ttggcctcac tttttcccag caataagtgg ggttcaccac    420

ccgcctcggg aatactttcc ccttctaaat gggacttgct gttacctcag gaggctcctt    480

agtgcaaata tgaccctggt cagggctttg ccaccgttga agccctgcag aaggtgcaat    540

gtaggggttc tggggccaca gaggagaggc cacttcccac caggaccccc aacatgaagt    600

ctaggcctca ggggctcccg cccttcttcc tccagcagcg ggaactgcca ctgctctccc    660

aggccctgtt ctggaggcta accttggttc ctggagagtg tgcccctcca ccctccctcc    720

agcagccctg atcacaccat gagagccagg aacgggtcac cctgctgaag atcactctgt    780

gccctggggg aggagccaag ccctcacccc acaaggggca ggtgggggct tggttgctga    840

cccggcccaa gtccccacag agcaccttct gtagctccag cttgtctccc tggcttctct    900

ttgaaggaga aaaatgtaaa atatgcactg agaaagccag ccccgcctgc ttagtcagcc    960

ccggcagcag ggcagccatg ggaactcagg aaaagcagga accctttcca aaagcccaga   1020

gatgccctgg gctcagatct gtaattctcc caggagctgt gatagagcag gccacacaaa   1080

gtcccatctc actctcttct tctttcacca attgctaaca tagaccttgt tgggatcacg   1140

atggcttcac aagccagctg ttgggtttgc tatgtcactg tggctcagtc acatccctgc   1200

gtgtatactg tctgcggggc acatatgtat ccatttagag ctaaaggaat cagtgtacac   1260

tacagctaat cctaataaat ccgatgtttt cgg                                1293


<210>  9790
<211>  46
<212>  PRT
<213>  Homosapiens

<400>  9790

Met Gly Thr Gln Glu Lys Gln Glu Pro Phe Pro Lys Ala Gln Arg Cys 
1               5                   10                  15      


Pro Gly Leu Arg Ser Val Ile Leu Pro Gly Ala Val Ile Glu Gln Ala 
            20                  25                  30          


Thr Gln Ser Pro Ile Ser Leu Ser Ser Ser Phe Thr Asn Cys 
        35                  40                  45      


<210>  9791
<211>  524
<212>  DNA
<213>  Homosapiens

<400>  9791
caagttgcag cctgaagtag gaaggaaata tggagatgct ggcatcctct ctccaataaa     60

gcattgaggt taaagactgg aatctgaaaa tacacagcaa tttcagggga atctgctgaa    120

actggaagat tgtttttgaa cttctgacct caggtgatcc acccacattg gcctcccaaa    180

gtgctgaggt tacaggcatg agccactgcg cctggcctgc cttctgtagc ttttgtctgt    240

aaaccaagta ctacagtaga aagaaggtgg gttttgccac ctattatata ataaggacat    300

ttttttcaaa tggtaactcc cgtgctgaca aggatgtggc aaaactcaaa cttccatact    360

ttgctgatga caatgaaatg tcaagttgaa aagcattttt agttctatgt attagaactc    420

atgaaaatat tcgtatcttt tgatctagaa atcccatttt ggtaagttta tcttgagaat    480

tccatagaca tctgtaaaaa gatgttcatt tcagtgttat ttat                     524


<210>  9792
<211>  30
<212>  PRT
<213>  Homosapiens

<400>  9792

Met Val Thr Pro Val Leu Thr Arg Met Trp Gln Asn Ser Asn Phe His 
1               5                   10                  15      


Thr Leu Leu Met Thr Met Lys Cys Gln Val Glu Lys His Phe 
            20                  25                  30  


<210>  9793
<211>  815
<212>  DNA
<213>  Homosapiens

<400>  9793
tgagtgtgtg gagggaccag aggtgaggat cactgatctg gcattgccct gccatagcag     60

tggtgtttct gggtgtctgg attacagcct caagacaatc accaccacca ctgagacatc    120

cctgggatgg agaaaagcga agatcagaaa tagctcccag gaatggtttt cattatcttc    180

tgccattgtt gccttctctg aaacacactg ctctcggtca ttcggtaggc tgactgcaaa    240

aatggcttca actccccctc ctccttccat ttgcacctgt ccatgccgct ctgcaaagtg    300

ccctgcagct cctcccagca aggctggagt ctgtgcttgt gactcactcg gaccaacaca    360

atgcagcaaa ggtgatgtgt gccacgcctg agcctgggct tgaaaggtct tgcgtcttct    420

gcttggtctc ttgaaaccct gctgccacca ggtgaacaag cccaagctaa cctactgggt    480

gatcagagac acatcctagt cacctctctt gcatctgtca ccccagccaa cagccagatg    540

attcccagac acagctgcca tgcgacctgc agctgaccac acatgtgtga ggggcccagc    600

tgagatgaga gaacagccca gctgagccca gacgcatgca ctggcttgaa gcatcatgag    660

atagataaat ggctgttgtc tgaagccgga acacctgatt cgtatggaca gaaggctgta    720

agaggaatca ttacaaaaat gagagacaca atagtcaaag gtgtaaataa aaaagaagcc    780

ccaaaagaaa acaagaagcc agaagagaag taacg                               815


<210>  9794
<211>  49
<212>  PRT
<213>  Homosapiens

<400>  9794

Met Ala Ser Thr Pro Pro Pro Pro Ser Ile Cys Thr Cys Pro Cys Arg 
1               5                   10                  15      


Ser Ala Lys Cys Pro Ala Ala Pro Pro Ser Lys Ala Gly Val Cys Ala 
            20                  25                  30          


Cys Asp Ser Leu Gly Pro Thr Gln Cys Ser Lys Gly Asp Val Cys His 
        35                  40                  45              


Ala 
    


<210>  9795
<211>  435
<212>  DNA
<213>  Homosapiens

<400>  9795
cactgcaggt ccgtgggtca gctggggtgt ctccgctcct cgtgtctctt atcctccttg     60

gacctagcca ggaatgctct catgggaatg gcagaggcaa agatggttgg gagaagaaca    120

atcaccaaaa atgcagagtg gggagcgggc ctgagtgttg gacctctcct taaacaaacc    180

ttcctgcagc ctccaggtca ccatccttgt cacctctact gccagagaca tcgagtgcct    240

tgaagtcctg ggctttccgg ggattctgtg gggtatttcc agtgaagtcc cactctcctc    300

aaccctcaga ggatctctgg aaggccacac agaacctggg acaggaacca aggcacaggg    360

atgggatgga gactcacaat tcactgttaa cattttgatt ctcatttgaa tttttaacac    420

acgcatctat cactt                                                     435


<210>  9796
<211>  53
<212>  PRT
<213>  Homosapiens

<400>  9796

Met Gly Met Ala Glu Ala Lys Met Val Gly Arg Arg Thr Ile Thr Lys 
1               5                   10                  15      


Asn Ala Glu Trp Gly Ala Gly Leu Ser Val Gly Pro Leu Leu Lys Gln 
            20                  25                  30          


Thr Phe Leu Gln Pro Pro Gly His His Pro Cys His Leu Tyr Cys Gln 
        35                  40                  45              


Arg His Arg Val Pro 
    50              


<210>  9797
<211>  4562
<212>  DNA
<213>  Homosapiens

<400>  9797
gcgggggacg ctcagtaggg tacgggacgc gcgcggggag accctgtgca gcgacaccgg     60

ggctgtagtc gccgtctgga accagcgcgg gaataggtgc gcaggcgcac agtggctgga    120

gggcagcggc ggcgtggtct cgggccactt ccaagcagag ggcagcacct gtcccctcgg    180

aggcgctgcc agcgccctcc ctcctcctcc gcagggcgcg ggacctctat ttatatcgcc    240

cagccagcac aggcccatat tgggcagtgg cctcagtcag gcccgctggc cgccctgcca    300

cacggtagcg tccaagccag gtcgtggccc agcgagtggg gacgcgcccc gaaccaggca    360

gcaccttcgt atcatgatag aggaaaccag ttttgggaaa agttatgcac agctgaattt    420

cgagaactct atgctctggg cagtattcat aatgaccttt atgttatagg aggacagatg    480

aaaattaaaa accagtatct tattacaaac tgtgttgata agtactctgt agaacgggac    540

aattggaaaa gggtgtctcc ccttccactg caattggcat gtcatgctgt agtgacagtg    600

aataataaac tttatgtaat tggaggctgg acccctcaga tggatcttcc tgatgaagaa    660

cctgatcgat taagcaacaa actgttgcag tatgacccca gccaagatca atggagtgtg    720

cgggcaccca tgaagtactc taagtaccga ttcagtacag ctgtagtcaa cagtgagatt    780

tatgttttgg gtggcattgg ctgtgtaggt caagacaagg gccaggttcg aaaatgcctt    840

gacgtggtgg agatctacaa cccagatggg gacttttggc gagagggccc tcccatgcca    900

agtcccctcc tctcactccg caccaattcc accaatgcag gggcagtgga tgggaaactc    960

tatgtctgcg ggggattcca tggagcagat cgccatgagg ttatctccaa agaaatattg   1020

gaactggacc catgggaaaa ccagtggaat gttgtagcca tcaacgtcct catgcatgac   1080

agctatgatg tctgcctagt agccaggatg aatccccgag acctcatccc cccgccttca   1140

gatttggtgg aagaaggcaa tgagcactaa ggtgaccttg ctggaggacc tcctgctgtt   1200

ctgcaaacaa ggccttcaga acggagaggg cccacagcat ctctgtcatg ccagtcatgt   1260

gcactgcatg cgtagtggcc tgtgtgtgaa gaagcagtgt gtgctgggca ctgggtgggg   1320

agcatgggga gtctcccttc agggacttcc cagcctgata gggtaaataa gacactacaa   1380

agaagaggtg atgacggcca caggaggggc acagggccac aggagagcag cagagggagg   1440

gtctcactct gctggggacc catgaacagc actgccaagg agcagacctt ttattgggtc   1500

cccaaaagga tgaggaggaa gtggtcccat gggtgcagtc aatgatgagt tcatggaaac   1560

agccaagcaa gggcccagag acagaaagct cgtgcctgtc tgcagtatcc tggctgggcc   1620

agattgcctg gggcacaggg tttgtggtca aggctggaaa agtaggttgt agctagatga   1680

ccaacgcctg aaagaatgag gagttggacc tggtctgtaa gccagggaat tgtctcaaaa   1740

tcgtgcatta agggagactt ctctctgtgc tctgttccag cttcagtctt ataaacactg   1800

accattctcc ttcagaatcc ccttctactg aagcaacgcc acccagcagc agggctagct   1860

gtactaccag cccctaacaa ccaaggcact caagccagac cacagtggcc aagaatcctg   1920

ccctgggctg actctgtccg ggacagggat gtggggttct gcagcctggt ccactccggg   1980

gctggcaggg agtgtcctgg agtgggctga cccaggctgc ctttgcccac ctctcagaca   2040

catacaacca tctgcagggt agtcctggct gaacaggact cgcccaagcc acccaagcca   2100

gggacagaga aggctctggc tgaggacagg ggaagaagca tctcctccag ctgctgccaa   2160

ccccatggcc cggcctttgc aataaagatg gagccaccca cttcagccca caattgagca   2220

taatcagaag acagtcactc ccaaaatata tgttagaaat aacatttaaa tgacacatgg   2280

gaagtccgtc tatcttactt cccgtctcta attctggaag cacagtggat tcaatgaggg   2340

catcttcata gctcttcttc agcaacttct ccaaagagtt tcacattgca caaggctctt   2400

ttggaagcag gagtggtcag taaattcaga gggagacaaa ccctaagtag agacagcttt   2460

ctttggtgct gagctgtgtg attgtgatga ccgctagcct gtgcccctag gttccagctg   2520

cccaccaggc aggacaggca ggtcttgcca aaactggagc ctgttggaaa cctatttctg   2580

ccaccaagga gagggaccag gagacccagc gtaggttggc cccaagtagg ctcaactcgg   2640

gagggtgggg gtcccgcctt tctcttcgca cttgtgcccc aagtgcactc acagtacctg   2700

gcatgtgggt gacctcttgg gtggccggca tggggcagtg tttctcaatc agagggcctg   2760

ggccccgagc acgtccagga atctgagtta aagtgagctt actctttccc cagtggatga   2820

tcatgatctg tgcattcttt ttcttgctac aaagatgttc ctcctagctg ctgtgttggc   2880

tgtcggcggc cagggttgag gacggcctcc acagggcctc cacttccctc cattcctctt   2940

cacatagtca ctccacctgc tccacctgct tgaaaagtcc agaaagctgc cgcgtctccc   3000

tggctcaagg aggccttgtt ggcatgtcat ggcacatctc ctagatgttt tgggttcaag   3060

atctgggttc cagcccccgc tctgctactt agctaaccat gtgaacttgg gcaagatgac   3120

ctttctaaag cctcatttcc ctcatatgca gagtgggaag gaaaatatta atacatactt   3180

tatagggttg gtatgaggat taagtgctga gcaaagtgcc tgtgaaatcc tgaaataata   3240

agcatgtttt agctgccatt attatcatca ctgtcattat cattgcagtc agcacttccc   3300

aaagcaaggt gcccaaaaca gactcagtgc tttagggaag tggggcagat gtgcatatgg   3360

cttgtgacgg ttctttcttt tttttttttt ttttgagacg gagtctctct ctctcgccag   3420

gctggagtgc agtgcagtgg cacgatctca gcccactgca acctccgcct cccaggttca   3480

agtgattctc ctgcctcagc ctcccaagta gctgggatta caggcgccca ccaccacacc   3540

cagctaattt ttgtattttt agtagagacg gggtttcacc atgttggcca ggatggtctc   3600

aatctcttga cctcgtgatc tgcccgcctc ggcctcccaa agtgctggga ttacaggcat   3660

gagcccctgc acctggctga gatggttctt aatttcccat accctgttgc ttggctcctc   3720

cagttggcgg ctgagagtta agcaagggtt tactcggatc tgaggccccc gatgccctca   3780

atggacacat tcaggaccct gtggcagctc agcagaggca cctgagggtc acgctaggtg   3840

agaccatcgc ccgcctgtgg gaggcaagat aagtgggtaa acatcattcc tgtctaatgc   3900

gaggtctggg cagtgtccca gtggaacttt ccagagagtg ccaagggagg accgagaagg   3960

ggcatgacct ctgctggagc caggagggca gtgaccagga gctggcttag cactgaaggg   4020

aagcaggcat caagggcagg atttctcaaa cttcttctga ggaatccccg aggtcgaaac   4080

cggtgcttca cagatttcag atgtctgatc ttgatttttc tttgattcca tacaacagat   4140

tgcttgcctg ggttagtgct tattttaagt tcttggtgct tcttgtctga cttctgtatt   4200

tgcaattaaa aacaacatga ccctccccac ctgcagccag atatcgttag aaattcaact   4260

tcgaaatata ttcctatcac tcctgttttc actttaatag aaggctgttg cagtactgca   4320

tgatgggctc ttataaaact tctactatct gctaattctt atctttgtga caggattgtt   4380

tgacactgag caaggaaaca caataaggaa gtaatttgga tgctaggctg gcagaagcct   4440

gcagctgtca accacagcct gccccagtgt gttcaacacg gtggcattgt tctccctgac   4500

ttcataatga gcaaatgttt cacatttgaa cttaaggaat aaatttttac taataaaaga   4560

tc                                                                  4562


<210>  9798
<211>  230
<212>  PRT
<213>  Homosapiens

<400>  9798

Met Lys Ile Lys Asn Gln Tyr Leu Ile Thr Asn Cys Val Asp Lys Tyr 
1               5                   10                  15      


Ser Val Glu Arg Asp Asn Trp Lys Arg Val Ser Pro Leu Pro Leu Gln 
            20                  25                  30          


Leu Ala Cys His Ala Val Val Thr Val Asn Asn Lys Leu Tyr Val Ile 
        35                  40                  45              


Gly Gly Trp Thr Pro Gln Met Asp Leu Pro Asp Glu Glu Pro Asp Arg 
    50                  55                  60                  


Leu Ser Asn Lys Leu Leu Gln Tyr Asp Pro Ser Gln Asp Gln Trp Ser 
65                  70                  75                  80  


Val Arg Ala Pro Met Lys Tyr Ser Lys Tyr Arg Phe Ser Thr Ala Val 
                85                  90                  95      


Val Asn Ser Glu Ile Tyr Val Leu Gly Gly Ile Gly Cys Val Gly Gln 
            100                 105                 110         


Asp Lys Gly Gln Val Arg Lys Cys Leu Asp Val Val Glu Ile Tyr Asn 
        115                 120                 125             


Pro Asp Gly Asp Phe Trp Arg Glu Gly Pro Pro Met Pro Ser Pro Leu 
    130                 135                 140                 


Leu Ser Leu Arg Thr Asn Ser Thr Asn Ala Gly Ala Val Asp Gly Lys 
145                 150                 155                 160 


Leu Tyr Val Cys Gly Gly Phe His Gly Ala Asp Arg His Glu Val Ile 
                165                 170                 175     


Ser Lys Glu Ile Leu Glu Leu Asp Pro Trp Glu Asn Gln Trp Asn Val 
            180                 185                 190         


Val Ala Ile Asn Val Leu Met His Asp Ser Tyr Asp Val Cys Leu Val 
        195                 200                 205             


Ala Arg Met Asn Pro Arg Asp Leu Ile Pro Pro Pro Ser Asp Leu Val 
    210                 215                 220                 


Glu Glu Gly Asn Glu His 
225                 230 


<210>  9799
<211>  4132
<212>  DNA
<213>  Homosapiens

<400>  9799
agtgtgtgtc aaaaatatat gatggaccac atggatgcct ccaactgttt aggtatctat     60

tattttgcaa agcagattgg agctgaagat ttatctgatc gatcaaagaa atatttatat    120

cagcactttg ccgaggtatc atgatagagg aaaccagttt tgggaaaagt tatgcacagc    180

tgaatttcga gaactctatg ctctgggcaa tggatcttcc tgatgaagaa cctgatcgat    240

taagcaacaa actgttgcag tatgacccca gccaagatca atggagtgtg cgggcaccca    300

tgaagtactc taagtaccga ttcagtacag ctgtagtcaa cagtgagatt tatgttttgg    360

gtggcattgg ctgtgtaggt caagacaagg gccaggttcg aaaatgcctt gacgtggtgg    420

agatctacaa cccagatggg gacttttggc gagagggccc tcccatgcca agtcccctcc    480

tctcactccg caccaattcc accaatgcag gggcagtgga tgggaaactc tatgtctgcg    540

ggggattcca tggagcagat cgccatgagg ttatctccaa agaaatattg gaactggacc    600

catgggaaaa ccagtggaat gttgtagcca tcaacgtcct catgcatgac agctatgatg    660

tctgcctagt agccaggatg aatccccgag acctcatccc cccgccttca gatttggtgg    720

aagaaggcaa tgagcactaa ggtgaccttg ctggaggacc tcctgctgtt ctgcaaacaa    780

ggccttcaga acggagaggg cccacagcat ctctgtcatg ccagtcatgt gcactgcatg    840

cgtagtggcc tgtgtgtgaa gaagcagtgt gtgctgggca ctgggtgggg agcatgggga    900

gtctcccttc agggacttcc cagcctgata gggtaaataa gacactacaa agaagaggtg    960

atgacggcca caggaggggc acagggccac aggagagcag cagagggagg gtctcactct   1020

gctggggacc catgaacagc actgccaagg agcagacctt ttattgggtc cccaaaagga   1080

tgaggaggaa gtggtcccat gggtgcagtc aatgatgagt tcatggaaac agccaagcaa   1140

gggcccagag acagaaagct cgtgcctgtc tgcagtatcc tggctgggcc agattgcctg   1200

gggcacaggg tttgtggtca aggctggaaa agtaggttgt agctagatga ccaacgcctg   1260

aaagaatgag gagttggacc tggtctgtaa gccagggaat tgtctcaaaa tcgtgcatta   1320

agggagactt ctctctgtgc tctgttccag cttcagtctt ataaacactg accattctcc   1380

ttcagaatcc ccttctactg aagcaacgcc acccagcagc agggctagct gtactaccag   1440

cccctaacaa ccaaggcact caagccagac cacagtggcc aagaatcctg ccctgggctg   1500

actctgtccg ggacagggat gtggggttct gcagcctggt ccactccggg gctggcaggg   1560

agtgtcctgg agtgggctga cccaggctgc ctttgcccac ctctcagaca catacaacca   1620

tctgcagggt agtcctggct gaacaggact cgcccaagcc acccaagcca gggacagaga   1680

aggctctggc tgaggacagg ggaagaagca tctcctccag ctgctgccaa ccccatggcc   1740

cggcctttgc aataaagatg gagccaccca cttcagccca caattgagca taatcagaag   1800

acagtcactc ccaaaatata tgttagaaat aacatttaaa tgacacatgg gaagtccgtc   1860

tatcttactt cccgtctcta attctggaag cacagtggat tcaatgaggg catcttcata   1920

gctcttcttc agcaacttct ccaaagagtt tcacattgca caaggctctt ttggaagcag   1980

gagtggtcag taaattcaga gggagacaaa ccctaagtag agacagcttt ctttggtgct   2040

gagctgtgtg attgtgatga ccgctagcct gtgcccctag gttccagctg cccaccaggc   2100

aggacaggca ggtcttgcca aaactggagc ctgttggaaa cctatttctg ccaccaagga   2160

gagggaccag gagacccagc gtaggttggc cccaagtagg ctcaactcgg gagggtgggg   2220

gtcccgcctt tctcttcgca cttgtgcccc aagtgcactc acagtacctg gcatgtgggt   2280

gacctcttgg gtggccggca tggggcagtg tttctcaatc agagggcctg ggccccgagc   2340

acgtccagga atctgagtta aagtgagctt actctttccc cagtggatga tcatgatctg   2400

tgcattcttt ttcttgctac aaagatgttc ctcctagctg ctgtgttggc tgtcggcggc   2460

cagggttgag gacggcctcc acagggcctc cacttccctc cattcctctt cacatagtca   2520

ctccacctgc tccacctgct tgaaaagtcc agaaagctgc cgcgtctccc tggctcaagg   2580

aggccttgtt ggcatgtcat ggcacatctc ctagatgttt tgggttcaag atctgggttc   2640

cagcccccgc tctgctactt agctaaccat gtgaacttgg gcaagatgac ctttctaaag   2700

cctcatttcc ctcatatgca gagtgggaag gaaaatatta atacatactt tatagggttg   2760

gtatgaggat taagtgctga gcaaagtgcc tgtgaaatcc tgaaataata agcatgtttt   2820

agctgccatt attatcatca ctgtcattat cattgcagtc agcacttccc aaagcaaggt   2880

gcccaaaaca gactcagtgc tttagggaag tggggcagat gtgcatatgg cttgtgacgg   2940

ttctttcttt tttttttttt ttttgagacg gagtctctct ctctcgccag gctggagtgc   3000

agtgcagtgg cacgatctca gcccactgca acctccgcct cccaggttca agtgattctc   3060

ctgcctcagc ctcccaagta gctgggatta caggcgccca ccaccacacc cagctaattt   3120

ttgtattttt agtagagacg gggtttcacc atgttggcca ggatggtctc aatctcttga   3180

cctcgtgatc tgcccgcctc ggcctcccaa agtgctggga ttacaggcat gagcccctgc   3240

acctggctga gatggttctt aatttcccat accctgttgc ttggctcctc cagttggcgg   3300

ctgagagtta agcaagggtt tactcggatc tgaggccccc gatgccctca atggacacat   3360

tcaggaccct gtggcagctc agcagaggca cctgagggtc acgctaggtg agaccatcgc   3420

ccgcctgtgg gaggcaagat aagtgggtaa acatcattcc tgtctaatgc gaggtctggg   3480

cagtgtccca gtggaacttt ccagagagtg ccaagggagg accgagaagg ggcatgacct   3540

ctgctggagc caggagggca gtgaccagga gctggcttag cactgaaggg aagcaggcat   3600

caagggcagg atttctcaaa cttcttctga ggaatccccg aggtcgaaac cggtgcttca   3660

cagatttcag atgtctgatc ttgatttttc tttgattcca tacaacagat tgcttgcctg   3720

ggttagtgct tattttaagt tcttggtgct tcttgtctga cttctgtatt tgcaattaaa   3780

aacaacatga ccctccccac ctgcagccag atatcgttag aaattcaact tcgaaatata   3840

ttcctatcac tcctgttttc actttaatag aaggctgttg cagtactgca tgatgggctc   3900

ttataaaact tctactatct gctaattctt atctttgtga caggattgtt tgacactgag   3960

caaggaaaca caataaggaa gtaatttgga tgctaggctg gcagaagcct gcagctgtca   4020

accacagcct gccccagtgt gttcaacacg gtggcattgt tctccctgac ttcataatga   4080

gcaaatgttt cacatttgaa cttaaggaat aaatttttac taataaaaga tc           4132


<210>  9800
<211>  199
<212>  PRT
<213>  Homosapiens

<400>  9800

Met Ile Glu Glu Thr Ser Phe Gly Lys Ser Tyr Ala Gln Leu Asn Phe 
1               5                   10                  15      


Glu Asn Ser Met Leu Trp Ala Met Asp Leu Pro Asp Glu Glu Pro Asp 
            20                  25                  30          


Arg Leu Ser Asn Lys Leu Leu Gln Tyr Asp Pro Ser Gln Asp Gln Trp 
        35                  40                  45              


Ser Val Arg Ala Pro Met Lys Tyr Ser Lys Tyr Arg Phe Ser Thr Ala 
    50                  55                  60                  


Val Val Asn Ser Glu Ile Tyr Val Leu Gly Gly Ile Gly Cys Val Gly 
65                  70                  75                  80  


Gln Asp Lys Gly Gln Val Arg Lys Cys Leu Asp Val Val Glu Ile Tyr 
                85                  90                  95      


Asn Pro Asp Gly Asp Phe Trp Arg Glu Gly Pro Pro Met Pro Ser Pro 
            100                 105                 110         


Leu Leu Ser Leu Arg Thr Asn Ser Thr Asn Ala Gly Ala Val Asp Gly 
        115                 120                 125             


Lys Leu Tyr Val Cys Gly Gly Phe His Gly Ala Asp Arg His Glu Val 
    130                 135                 140                 


Ile Ser Lys Glu Ile Leu Glu Leu Asp Pro Trp Glu Asn Gln Trp Asn 
145                 150                 155                 160 


Val Val Ala Ile Asn Val Leu Met His Asp Ser Tyr Asp Val Cys Leu 
                165                 170                 175     


Val Ala Arg Met Asn Pro Arg Asp Leu Ile Pro Pro Pro Ser Asp Leu 
            180                 185                 190         


Val Glu Glu Gly Asn Glu His 
        195                 


<210>  9801
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9801
atggcagtaa attttttaaa gtttttggtt cgttcatatg tttgtggttt tgcaggccct     60

gagtatgcag atgttgtgtt tttggtggac agctctgatc gcctgggatc caagtccttc    120

ccatttgtga aaatgttcat caccaaaatg atcagcagtc tccccataga ggccgacaaa    180

taccgtgtgg ccctggccca gtacagtgat aaacttcaca gtgaattcca cctgagcacc    240

ttcaaaggca ggagccccat gctgaaccac ctaaggaaga actttggatt cattggcggg    300

tccctgcaga taggaaaggc tcttcaggag gctcacagga cttatttctc tgcacccgca    360

aatgggagag acaagaaaca gtttccccca attctagtgg tcctggcttc atctgagtct    420

gaggataatg tggaagaggc atcaaaggcc ctgcggaaag acggagtgaa aatcatctct    480

gtaggggtgc agaaagcttc tgaggaaaac ctgaaggcca tggccacgtc tcagtttcat    540

ttcaaccttc ggacagtcag agacctcagc atgttttccc aaaacatgac acacatcatc    600

aaggatgtaa taaagtacaa ggagggagca gttgatgaca tctttgtaga agcttgccaa    660

ggcccttcta tggccgatgt tgtgttccta ttggatatgt caatcaatgg aagtgaggag    720

aactttgact atcttaaagg attcttggaa gaaagtgtat ctgcccttga cataaaggaa    780

aattgcatga gggttggcct tgtggcctat agcaatgaga caaaagtgat aaattcactg    840

agcatgggca taaataagtc agaggttctc cagcatatac agaacctttc tccccgaact    900

gggaaggcct atactggagc tgccatcaaa aagctcagga aggaagtttt tagtgcacgg    960

aatggcagtc ggaagaatca gggggtgccc cagattgccg tgctggtgac ccaccgagat   1020

tcagaagaca acgtgacaaa agcagctgtt aacctccgac gggagggtgt gaccatcttc   1080

accctgggca tagagggcgc cagcgacacc cagttggaaa agatagcatc ccaccctgct   1140

gagcagtatg tctccaaact gaagaccttc gctgacctgg ctgctcacaa ccagacattt   1200

ctgaagaagc tgcggaacca aataacacac acagtctctg tcttttcaga gaggactgaa   1260

acgctcaaat ctggttgtgt ggacactgag gaagcagaca tctatctgct tatcgatggc   1320

tcagggagca cccaggccac agatttccat gaaatgaaga cgttcctgtc agaggtggta   1380

gggatgttca acattgctcc ccataaggtg cgggttgggg ccgttcagta tgctgacagc   1440

tgggacttgg aatttgagat caataaatac tccaacaagc aggatttggg aaaggccatt   1500

gagaatatca ggcagatggg tgggaataca aacacaggcg cagcactgaa tttcacactg   1560

agtctgttgc aaaaagcaaa gaagcagcga ggaaacaaag ttccatgcca ccttgttgtc   1620

ctgacaaatg gcatgtccaa ggatagcatc ttggagcctg caaacagact gagagaagag   1680

cacatccgag tttatgctat cgggatcaag gaggccaacc aaacacagct gagagaaatt   1740

gcaggagagg aaaagagagt gtattacgtg catgactttg atgcattgaa agacataaga   1800

aaccaagttg ttcaagaaat ctgtactgaa gaagcttgca aagagatgaa agctgacatc   1860

atgtttctgg tggacagttc tggaagtata ggacctgaaa acttcagcaa aatgaaaaca   1920

tttatgaaaa acctggtgag caagtctcag attggaccag atcgggtgca aattggtgta   1980

gtccagttca gcgacatcaa taaggaagag tttcagctca acagattcat gtcccaaagc   2040

gacatttcaa atgcaataga ccaaatggct cacattggac aaaccaccct gactggtagt   2100

gccctgagct ttgtgtctca gtacttcagc cccaccaagg gcgcccggcc caacatcaga   2160

aagtttctca tcctcatcac ggatggtgaa gctcaggaca tagtaaagga accagcagta   2220

gtgcttcggc aagaaggtgt aatcatctat tctgtgggag tgtttggctc caatgtcacc   2280

cagcttgagg agatcagtgg gaggcccgag atggtttttt atgttgagaa ttttgacatt   2340

ctgcagcgca ttgaagatga tcttgttttt ggaatatgca gcccccgtga agaatgcaag   2400

cggattgaag ttttagacgt tgtgtttgtc attgatagct ctggcagtat tgactatgat   2460

gagtataata tcatgaagga ttttatgatt ggcttagtga aaaaagctga tgtgggcaag   2520

aatcaggtcc ggtttggggc tctgaagtat gctgatgacc cagaggtgct gttttatctg   2580

gatgactttg gcacaaaact ggaggtaatt tcagtgctcc agaatgacca agccatgggt   2640

ggcagtactt atactgctga ggcactgggc ttctcagacc acatgttcac tgaagcccgg   2700

ggcagccgcc tgaacaaggg ggtcccccaa gtcctcattg tgatcaccga tggggaatcc   2760

catgatgctg ataaactcaa tgccacggca aaggccttgc gggacaaagg cattcttgtc   2820

ctggctgtgg ggattgatgg tgccaatccc gtggagctgt tagccatggc aggatcaagc   2880

gacaagtact tcttcgtgga gacttttgga ggtctgaagg gaatattttc agatgtgaca   2940

gccagtgtct gcaactcttc aaaagtagat tgtgaaattg acaaagtaga tcttgttttc   3000

cttatggatg gttcaactag cattcagcca aatgacttca agaaaatgaa ggaatttctg   3060

gcatctgttg ttcaagactt tgatgtcagc ctcaacagag tgcgaatagg agcggcccag   3120

tttagcgata cctatcaccc ggagtttcca ctgggaactt tcataggtga aaaagagata   3180

tcatttcaga ttgaaaacat caagcagatc tttggaaaca cacacatcgg tgctgcactc   3240

agggaggtgg aacattactt caggccagac atgggcagca ggataaatac aggtacccca   3300

caggtgctgc tggtccttac agatggccag tcccaagacg aggtggccca ggccgcggaa   3360

gccctgagac acagaggtat cgacatctac tccgtgggca ttggggatgt ggatgaccag   3420

cagctcattc agatcaccgg gactgcagag aaaaaactga cagtgcacaa cttcgatgaa   3480

ctgaagaagg tcaataaaag gatcgttcgc aacatctgta ccacagcggg tgaaagcagt   3540

gtgaggaaaa ggccattgtt tgcaatctgg ctggtttcag aggttgaaga gcaatgcctc   3600

aaagaaagga aatatttgac tgatttttgg ttgcttggca atacggccta tagggctgcc   3660

aagagctgtg gtacagactg tttcgtggat gttgtggtgg gatttgatgt ctcaactcag   3720

gagaaagggc agactttgct tgaaggtcag ccttggatgg aaacctacct tcaagacatc   3780

ttacgtgcca tcagctccct caatggagta agctgtgagg tgggcacaga gactcaggtc   3840

agtgtggctt ttcaagtgac caatgccatg gaaaaatatt ctcccaagtt tgagatctac   3900

agtgaaaaca tactgaatag cttgaaggat ataacagtta aaggaccatc tcttctcaat   3960

gcaaacctct tggattctct atgggataca tttcagaata aatcagctgc tcgaggaaag   4020

gtggtccttt tattttcaga tggattggat gatgatgttg agaaacttga acaaaaatct   4080

gatgaactta gaaaagaagg cctgaatgcc ctcataactg ttgctctgga tggacctgct   4140

gattcaagtg acttggctga tcttccctat attgaatttg ggaaaggatt tgagtacagg   4200

acacagctct ctattggcat gagagaactt ggaagccggc tgtcaaagca gctggtcaat   4260

gttgctgaaa ggacatgctg ctgtttgttc tgcaagtgca ttggaggaga tggcacaatg   4320

ggagatcctg gaccaccagg gaaaaggctt catgtaaaga gagtggtaga tttttttaaa   4380

aaacaaggct cagaaagaat ggaaagaaag ggacctccag gttttaaagg cagtgaaggc   4440

tacctgggag aggagggaat cgctggagaa agaggagccc ctggaccagt gggagagcaa   4500

ggtactaagg gatgctatgg caccaaaggt cctaagggaa acagaggact aaatggacag   4560

gagggagaag ttggggaaaa tggaattgac ggattaaacg gagaacaggg tgataatggt   4620

cttcctggaa gaaaaggaga aaagggagat gagggatctc agggaagccc agggaagaga   4680

gggactcctg gtgaccgtgg agcaaagggc ctgcgagggg atcccgtaag tgcacgggct   4740

gcaaactgga gttagggctt gattcccatc cgtacttctg atagggagtc tcgatttcaa   4800

gggagctcct ggagttgaca gtagcataga aggacccaca ggcttgaaag gagaacgtgg   4860

aagacaaggc agaagaggct ggccaggccc ccccgggaca ccaggctcca gaagaaagac   4920

agcagctcat ggcagaaggg gacatacagg cccacaggga acagcaggca tcccaggacc   4980

agatggactt gaaggctccc tgggacttaa gggccctcag ggcccaagag gagaggctgg   5040

tgtgaaagga gaaaaaggag gtgtgggaag taaaggtccc caggggcctc caggacccgg   5100

aggagaggca gggaatcaag gccgtttggg aagccaagga aataaaggag aacctggaga   5160

tctgggagaa aaaggagctg ttggctttcc tggtcctcgt ggcttgcagg gcaatgatgg   5220

cagtccaggt tatggtagtg tcggacgcaa gggagcaaag ggacaagaag gattccctgg   5280

agaaagtgga cctaagggtg agattgggga ccctggtggt ccaggagaga ctgggctgaa   5340

gggagctaga ggcaaaatga tatctgctgg gcttccagga gagatgggat cccctgggga   5400

accaggacct cctggacgta agggtgtgaa aggagccaaa ggcttggctt cattttctac   5460

atgtgagctc attcagtatg tgcgagaccg cagtcctggc aggcatgatt gacgacactg   5520

gcacatttca agtaatagtg gttccctccg gggccgacta cataccagca ttagagagac   5580

tccagcggtg cactttctgc tatgatgtgt gcaagccaga tgcttcttgt gaccaagcca   5640

gaccaccccc tgtgcagtct tacatggatg ctgctttcct tctggatgcc tcccggaaca   5700

tgggaagtgc tgaatttgaa gacataagag ccttccttgg agcactatta gatcactttg   5760

aaatcacccc agagccggag acttctgtca ctggagaccg ggtggcccta ttgagccatg   5820

ctccccccga cttcctaccc aacactcaga agagtccagt tagagctgag ttcaatctta   5880

ccacctacag aagtaagcgc ctcatgaaga ggcatgtgca cgagtcagtt aaacaactaa   5940

atggagatgc ttttattggt catgccttac agtggactct ggacaatgta tttttaagta   6000

cacccaatct gagaagaaac aaagtcatat ttgtgatatc tgctggggaa accagccact   6060

tagatgggga aatcttaaag aaggaatcct tgcgagccaa atgtcaggga tatgccttat   6120

ttgtgttttc ccttggccct atttgggatg acaaggaact ggaggatctc gccagccacc   6180

ctttggatca ccacctggtc cagcttggcc gaattcataa acctgaccac agttatggtg   6240

tgaagtttgt gaagtccttt ataaactcaa tcaggcgtgc aatcaacaaa tatccaccaa   6300

taaacttaaa aataaagtgc aacagactta actctataga tccaaagcag cccccacgac   6360

cattccgaag ctttgttcct ggaccactta aagctaccct caaagaagat gtattacaga   6420

aggcaaaatt ctttcaagat aaaaaatatc tttcaagagt agcaagaagt ggcagagatg   6480

atgctattca aaattttatg agaagcacct cccatacctt taagaatgga aggatgatag   6540

aaagtgctcc caaacaacat gattaaaaaa atgcttgaac aacttagcct taggaagcat   6600

ggtaagactc tggacttaaa tagtaactaa atctgctgcc agaactcaag caacagtttg   6660

taggttatca ggtgacttga ccccctgcat tcattggtat taagatatat cttgttcatt   6720

tatttgacca ctcctgacaa ttccagcact ctacgactga tatgtcgaag aactgtttca   6780

ttagaagaca gaagaatgaa agaagtgttt tgaaaagtct aatggagata taatttgaag   6840

gtaaaattta tatgatgtat gcatatgtgt acatgggtca atgttaattc ttttatctct   6900

gtccagttca ttttctgcaa acccatcctc ctttcctaat ttagtaatgt ctaatgctca   6960

tctatttagt caaagttatt ttttaatgtt ttaagctact ccaaaattta tcctagaaat   7020

ggatgctgtt tatatgtcgt atttttttaa aacgtgacct tctattccac ttaaacacac   7080

cactgtggga gttgtttgct tggactgatg agaagagggt aattttctcc atctctaaat   7140

cctcctgaac tcactgaaaa actcattaat tcccgcagaa cataaattat tgcttttgag   7200

ctggaagttt tctcttcatt aggaagctta ctgccatttt gatggagctt gaagccccca   7260

ttttgatgga cttctagtct gtctttcctg ttatggtcat ttattaattt tcactaatcc   7320

atatattctt tagacaagga gagtcaagaa actacttgtc atagatgaag ctctgagtta   7380

cttttaccca tcaggtagct gtttagtcaa taataaacag caccaaaaca ggattagcag   7440

agctcttaaa aacagcctta aatacacact gagtttagaa aaatgtaaga aaatcattgt   7500

tttaatctac aaattcatat gcagttgcag agatgcaaaa gagatcagag taagttaaag   7560

taggaaaggt tttataaaag tattgatggc tgtgtcctca tctgcatttt tgtttttatg   7620

atagggctga tattttcaac aacgaaacac ccaatgttca gaccttacct cagtctaaga   7680

gctggctcca cagttggtag caatggccct gttaggcaga ctgtccccct ctttgggaat   7740

ggaaagaagc cctgcctgga tgcatggagc agatggatac tgacaccaag gacattcaga   7800

ttttctttcc tatacctatt ttcataaaat ttggaaagaa aaactatctg cagtattttt   7860

ttaaaacgac ttctgctatt cttacttaga gaaatccagt gatagcacct catgtcttca   7920

gaggagcaag aagttcaagg agttaaatgt cacattcata ctcaggtaat agagaagaat   7980

aaaacacatc aggtttgctt catctatcct aagtggtgct taggggttca gaaaaaatgt   8040

ttcaagtaca ggaaattaat gagcaatatt tacaatgtat tttaataaaa gggatttttc   8100

tagttaactc tgagttaagc acgaactcct ttcttttgtt aattgttgga aataccatta   8160

agatgtattt gtctgttttt ctgcattggc aa                                 8192


<210>  9802
<211>  1584
<212>  PRT
<213>  Homosapiens

<400>  9802

Met Ala Val Asn Phe Leu Lys Phe Leu Val Arg Ser Tyr Val Cys Gly 
1               5                   10                  15      


Phe Ala Gly Pro Glu Tyr Ala Asp Val Val Phe Leu Val Asp Ser Ser 
            20                  25                  30          


Asp Arg Leu Gly Ser Lys Ser Phe Pro Phe Val Lys Met Phe Ile Thr 
        35                  40                  45              


Lys Met Ile Ser Ser Leu Pro Ile Glu Ala Asp Lys Tyr Arg Val Ala 
    50                  55                  60                  


Leu Ala Gln Tyr Ser Asp Lys Leu His Ser Glu Phe His Leu Ser Thr 
65                  70                  75                  80  


Phe Lys Gly Arg Ser Pro Met Leu Asn His Leu Arg Lys Asn Phe Gly 
                85                  90                  95      


Phe Ile Gly Gly Ser Leu Gln Ile Gly Lys Ala Leu Gln Glu Ala His 
            100                 105                 110         


Arg Thr Tyr Phe Ser Ala Pro Ala Asn Gly Arg Asp Lys Lys Gln Phe 
        115                 120                 125             


Pro Pro Ile Leu Val Val Leu Ala Ser Ser Glu Ser Glu Asp Asn Val 
    130                 135                 140                 


Glu Glu Ala Ser Lys Ala Leu Arg Lys Asp Gly Val Lys Ile Ile Ser 
145                 150                 155                 160 


Val Gly Val Gln Lys Ala Ser Glu Glu Asn Leu Lys Ala Met Ala Thr 
                165                 170                 175     


Ser Gln Phe His Phe Asn Leu Arg Thr Val Arg Asp Leu Ser Met Phe 
            180                 185                 190         


Ser Gln Asn Met Thr His Ile Ile Lys Asp Val Ile Lys Tyr Lys Glu 
        195                 200                 205             


Gly Ala Val Asp Asp Ile Phe Val Glu Ala Cys Gln Gly Pro Ser Met 
    210                 215                 220                 


Ala Asp Val Val Phe Leu Leu Asp Met Ser Ile Asn Gly Ser Glu Glu 
225                 230                 235                 240 


Asn Phe Asp Tyr Leu Lys Gly Phe Leu Glu Glu Ser Val Ser Ala Leu 
                245                 250                 255     


Asp Ile Lys Glu Asn Cys Met Arg Val Gly Leu Val Ala Tyr Ser Asn 
            260                 265                 270         


Glu Thr Lys Val Ile Asn Ser Leu Ser Met Gly Ile Asn Lys Ser Glu 
        275                 280                 285             


Val Leu Gln His Ile Gln Asn Leu Ser Pro Arg Thr Gly Lys Ala Tyr 
    290                 295                 300                 


Thr Gly Ala Ala Ile Lys Lys Leu Arg Lys Glu Val Phe Ser Ala Arg 
305                 310                 315                 320 


Asn Gly Ser Arg Lys Asn Gln Gly Val Pro Gln Ile Ala Val Leu Val 
                325                 330                 335     


Thr His Arg Asp Ser Glu Asp Asn Val Thr Lys Ala Ala Val Asn Leu 
            340                 345                 350         


Arg Arg Glu Gly Val Thr Ile Phe Thr Leu Gly Ile Glu Gly Ala Ser 
        355                 360                 365             


Asp Thr Gln Leu Glu Lys Ile Ala Ser His Pro Ala Glu Gln Tyr Val 
    370                 375                 380                 


Ser Lys Leu Lys Thr Phe Ala Asp Leu Ala Ala His Asn Gln Thr Phe 
385                 390                 395                 400 


Leu Lys Lys Leu Arg Asn Gln Ile Thr His Thr Val Ser Val Phe Ser 
                405                 410                 415     


Glu Arg Thr Glu Thr Leu Lys Ser Gly Cys Val Asp Thr Glu Glu Ala 
            420                 425                 430         


Asp Ile Tyr Leu Leu Ile Asp Gly Ser Gly Ser Thr Gln Ala Thr Asp 
        435                 440                 445             


Phe His Glu Met Lys Thr Phe Leu Ser Glu Val Val Gly Met Phe Asn 
    450                 455                 460                 


Ile Ala Pro His Lys Val Arg Val Gly Ala Val Gln Tyr Ala Asp Ser 
465                 470                 475                 480 


Trp Asp Leu Glu Phe Glu Ile Asn Lys Tyr Ser Asn Lys Gln Asp Leu 
                485                 490                 495     


Gly Lys Ala Ile Glu Asn Ile Arg Gln Met Gly Gly Asn Thr Asn Thr 
            500                 505                 510         


Gly Ala Ala Leu Asn Phe Thr Leu Ser Leu Leu Gln Lys Ala Lys Lys 
        515                 520                 525             


Gln Arg Gly Asn Lys Val Pro Cys His Leu Val Val Leu Thr Asn Gly 
    530                 535                 540                 


Met Ser Lys Asp Ser Ile Leu Glu Pro Ala Asn Arg Leu Arg Glu Glu 
545                 550                 555                 560 


His Ile Arg Val Tyr Ala Ile Gly Ile Lys Glu Ala Asn Gln Thr Gln 
                565                 570                 575     


Leu Arg Glu Ile Ala Gly Glu Glu Lys Arg Val Tyr Tyr Val His Asp 
            580                 585                 590         


Phe Asp Ala Leu Lys Asp Ile Arg Asn Gln Val Val Gln Glu Ile Cys 
        595                 600                 605             


Thr Glu Glu Ala Cys Lys Glu Met Lys Ala Asp Ile Met Phe Leu Val 
    610                 615                 620                 


Asp Ser Ser Gly Ser Ile Gly Pro Glu Asn Phe Ser Lys Met Lys Thr 
625                 630                 635                 640 


Phe Met Lys Asn Leu Val Ser Lys Ser Gln Ile Gly Pro Asp Arg Val 
                645                 650                 655     


Gln Ile Gly Val Val Gln Phe Ser Asp Ile Asn Lys Glu Glu Phe Gln 
            660                 665                 670         


Leu Asn Arg Phe Met Ser Gln Ser Asp Ile Ser Asn Ala Ile Asp Gln 
        675                 680                 685             


Met Ala His Ile Gly Gln Thr Thr Leu Thr Gly Ser Ala Leu Ser Phe 
    690                 695                 700                 


Val Ser Gln Tyr Phe Ser Pro Thr Lys Gly Ala Arg Pro Asn Ile Arg 
705                 710                 715                 720 


Lys Phe Leu Ile Leu Ile Thr Asp Gly Glu Ala Gln Asp Ile Val Lys 
                725                 730                 735     


Glu Pro Ala Val Val Leu Arg Gln Glu Gly Val Ile Ile Tyr Ser Val 
            740                 745                 750         


Gly Val Phe Gly Ser Asn Val Thr Gln Leu Glu Glu Ile Ser Gly Arg 
        755                 760                 765             


Pro Glu Met Val Phe Tyr Val Glu Asn Phe Asp Ile Leu Gln Arg Ile 
    770                 775                 780                 


Glu Asp Asp Leu Val Phe Gly Ile Cys Ser Pro Arg Glu Glu Cys Lys 
785                 790                 795                 800 


Arg Ile Glu Val Leu Asp Val Val Phe Val Ile Asp Ser Ser Gly Ser 
                805                 810                 815     


Ile Asp Tyr Asp Glu Tyr Asn Ile Met Lys Asp Phe Met Ile Gly Leu 
            820                 825                 830         


Val Lys Lys Ala Asp Val Gly Lys Asn Gln Val Arg Phe Gly Ala Leu 
        835                 840                 845             


Lys Tyr Ala Asp Asp Pro Glu Val Leu Phe Tyr Leu Asp Asp Phe Gly 
    850                 855                 860                 


Thr Lys Leu Glu Val Ile Ser Val Leu Gln Asn Asp Gln Ala Met Gly 
865                 870                 875                 880 


Gly Ser Thr Tyr Thr Ala Glu Ala Leu Gly Phe Ser Asp His Met Phe 
                885                 890                 895     


Thr Glu Ala Arg Gly Ser Arg Leu Asn Lys Gly Val Pro Gln Val Leu 
            900                 905                 910         


Ile Val Ile Thr Asp Gly Glu Ser His Asp Ala Asp Lys Leu Asn Ala 
        915                 920                 925             


Thr Ala Lys Ala Leu Arg Asp Lys Gly Ile Leu Val Leu Ala Val Gly 
    930                 935                 940                 


Ile Asp Gly Ala Asn Pro Val Glu Leu Leu Ala Met Ala Gly Ser Ser 
945                 950                 955                 960 


Asp Lys Tyr Phe Phe Val Glu Thr Phe Gly Gly Leu Lys Gly Ile Phe 
                965                 970                 975     


Ser Asp Val Thr Ala Ser Val Cys Asn Ser Ser Lys Val Asp Cys Glu 
            980                 985                 990         


Ile Asp Lys Val Asp Leu Val Phe  Leu Met Asp Gly Ser  Thr Ser Ile 
        995                 1000                 1005             


Gln Pro  Asn Asp Phe Lys Lys  Met Lys Glu Phe Leu  Ala Ser Val 
    1010                 1015                 1020             


Val Gln  Asp Phe Asp Val Ser  Leu Asn Arg Val Arg  Ile Gly Ala 
    1025                 1030                 1035             


Ala Gln  Phe Ser Asp Thr Tyr  His Pro Glu Phe Pro  Leu Gly Thr 
    1040                 1045                 1050             


Phe Ile  Gly Glu Lys Glu Ile  Ser Phe Gln Ile Glu  Asn Ile Lys 
    1055                 1060                 1065             


Gln Ile  Phe Gly Asn Thr His  Ile Gly Ala Ala Leu  Arg Glu Val 
    1070                 1075                 1080             


Glu His  Tyr Phe Arg Pro Asp  Met Gly Ser Arg Ile  Asn Thr Gly 
    1085                 1090                 1095             


Thr Pro  Gln Val Leu Leu Val  Leu Thr Asp Gly Gln  Ser Gln Asp 
    1100                 1105                 1110             


Glu Val  Ala Gln Ala Ala Glu  Ala Leu Arg His Arg  Gly Ile Asp 
    1115                 1120                 1125             


Ile Tyr  Ser Val Gly Ile Gly  Asp Val Asp Asp Gln  Gln Leu Ile 
    1130                 1135                 1140             


Gln Ile  Thr Gly Thr Ala Glu  Lys Lys Leu Thr Val  His Asn Phe 
    1145                 1150                 1155             


Asp Glu  Leu Lys Lys Val Asn  Lys Arg Ile Val Arg  Asn Ile Cys 
    1160                 1165                 1170             


Thr Thr  Ala Gly Glu Ser Ser  Val Arg Lys Arg Pro  Leu Phe Ala 
    1175                 1180                 1185             


Ile Trp  Leu Val Ser Glu Val  Glu Glu Gln Cys Leu  Lys Glu Arg 
    1190                 1195                 1200             


Lys Tyr  Leu Thr Asp Phe Trp  Leu Leu Gly Asn Thr  Ala Tyr Arg 
    1205                 1210                 1215             


Ala Ala  Lys Ser Cys Gly Thr  Asp Cys Phe Val Asp  Val Val Val 
    1220                 1225                 1230             


Gly Phe  Asp Val Ser Thr Gln  Glu Lys Gly Gln Thr  Leu Leu Glu 
    1235                 1240                 1245             


Gly Gln  Pro Trp Met Glu Thr  Tyr Leu Gln Asp Ile  Leu Arg Ala 
    1250                 1255                 1260             


Ile Ser  Ser Leu Asn Gly Val  Ser Cys Glu Val Gly  Thr Glu Thr 
    1265                 1270                 1275             


Gln Val  Ser Val Ala Phe Gln  Val Thr Asn Ala Met  Glu Lys Tyr 
    1280                 1285                 1290             


Ser Pro  Lys Phe Glu Ile Tyr  Ser Glu Asn Ile Leu  Asn Ser Leu 
    1295                 1300                 1305             


Lys Asp  Ile Thr Val Lys Gly  Pro Ser Leu Leu Asn  Ala Asn Leu 
    1310                 1315                 1320             


Leu Asp  Ser Leu Trp Asp Thr  Phe Gln Asn Lys Ser  Ala Ala Arg 
    1325                 1330                 1335             


Gly Lys  Val Val Leu Leu Phe  Ser Asp Gly Leu Asp  Asp Asp Val 
    1340                 1345                 1350             


Glu Lys  Leu Glu Gln Lys Ser  Asp Glu Leu Arg Lys  Glu Gly Leu 
    1355                 1360                 1365             


Asn Ala  Leu Ile Thr Val Ala  Leu Asp Gly Pro Ala  Asp Ser Ser 
    1370                 1375                 1380             


Asp Leu  Ala Asp Leu Pro Tyr  Ile Glu Phe Gly Lys  Gly Phe Glu 
    1385                 1390                 1395             


Tyr Arg  Thr Gln Leu Ser Ile  Gly Met Arg Glu Leu  Gly Ser Arg 
    1400                 1405                 1410             


Leu Ser  Lys Gln Leu Val Asn  Val Ala Glu Arg Thr  Cys Cys Cys 
    1415                 1420                 1425             


Leu Phe  Cys Lys Cys Ile Gly  Gly Asp Gly Thr Met  Gly Asp Pro 
    1430                 1435                 1440             


Gly Pro  Pro Gly Lys Arg Leu  His Val Lys Arg Val  Val Asp Phe 
    1445                 1450                 1455             


Phe Lys  Lys Gln Gly Ser Glu  Arg Met Glu Arg Lys  Gly Pro Pro 
    1460                 1465                 1470             


Gly Phe  Lys Gly Ser Glu Gly  Tyr Leu Gly Glu Glu  Gly Ile Ala 
    1475                 1480                 1485             


Gly Glu  Arg Gly Ala Pro Gly  Pro Val Gly Glu Gln  Gly Thr Lys 
    1490                 1495                 1500             


Gly Cys  Tyr Gly Thr Lys Gly  Pro Lys Gly Asn Arg  Gly Leu Asn 
    1505                 1510                 1515             


Gly Gln  Glu Gly Glu Val Gly  Glu Asn Gly Ile Asp  Gly Leu Asn 
    1520                 1525                 1530             


Gly Glu  Gln Gly Asp Asn Gly  Leu Pro Gly Arg Lys  Gly Glu Lys 
    1535                 1540                 1545             


Gly Asp  Glu Gly Ser Gln Gly  Ser Pro Gly Lys Arg  Gly Thr Pro 
    1550                 1555                 1560             


Gly Asp  Arg Gly Ala Lys Gly  Leu Arg Gly Asp Pro  Val Ser Ala 
    1565                 1570                 1575             


Arg Ala  Ala Asn Trp Ser 
    1580                 


<210>  9803
<211>  8192
<212>  DNA
<213>  Homosapiens

<400>  9803
atggcagtaa attttttaaa gtttttggtt cgttcatatg tttgtggttt tgcaggccct     60

gagtatgcag atgttgtgtt tttggtggac agctctgatc gcctgggatc caagtccttc    120

ccatttgtga aaatgttcat caccaaaatg atcagcagtc tccccataga ggccgacaaa    180

taccgtgtgg ccctggccca gtacagtgat aaacttcaca gtgaattcca cctgagcacc    240

ttcaaaggca ggagccccat gctgaaccac ctaaggaaga actttggatt cattggcggg    300

tccctgcaga taggaaaggc tcttcaggag gctcacagga cttatttctc tgcacccgca    360

aatgggagag acaagaaaca gtttccccca attctagtgg tcctggcttc atctgagtct    420

gaggataatg tggaagaggc atcaaaggcc ctgcggaaag acggagtgaa aatcatctct    480

gtaggggtgc agaaagcttc tgaggaaaac ctgaaggcca tggccacgtc tcagtttcat    540

ttcaaccttc ggacagtcag agacctcagc atgttttccc aaaacatgac acacatcatc    600

aaggatgtaa taaagtacaa ggagggagca gttgatgaca tctttgtaga agcttgccaa    660

ggcccttcta tggccgatgt tgtgttccta ttggatatgt caatcaatgg aagtgaggag    720

aactttgact atcttaaagg attcttggaa gaaagtgtat ctgcccttga cataaaggaa    780

aattgcatga gggttggcct tgtggcctat agcaatgaga caaaagtgat aaattcactg    840

agcatgggca taaataagtc agaggttctc cagcatatac agaacctttc tccccgaact    900

gggaaggcct atactggagc tgccatcaaa aagctcagga aggaagtttt tagtgcacgg    960

aatggcagtc ggaagaatca gggggtgccc cagattgccg tgctggtgac ccaccgagat   1020

tcagaagaca acgtgacaaa agcagctgtt aacctccgac gggagggtgt gaccatcttc   1080

accctgggca tagagggcgc cagcgacacc cagttggaaa agatagcatc ccaccctgct   1140

gagcagtatg tctccaaact gaagaccttc gctgacctgg ctgctcacaa ccagacattt   1200

ctgaagaagc tgcggaacca aataacacac acagtctctg tcttttcaga gaggactgaa   1260

acgctcaaat ctggttgtgt ggacactgag gaagcagaca tctatctgct tatcgatggc   1320

tcagggagca cccaggccac agatttccat gaaatgaaga cgttcctgtc agaggtggta   1380

gggatgttca acattgctcc ccataaggtg cgggttgggg ccgttcagta tgctgacagc   1440

tgggacttgg aatttgagat caataaatac tccaacaagc aggatttggg aaaggccatt   1500

gagaatatca ggcagatggg tgggaataca aacacaggcg cagcactgaa tttcacactg   1560

agtctgttgc aaaaagcaaa gaagcagcga ggaaacaaag ttccatgcca ccttgttgtc   1620

ctgacaaatg gcatgtccaa ggatagcatc ttggagcctg caaacagact gagagaagag   1680

cacatccgag tttatgctat cgggatcaag gaggccaacc aaacacagct gagagaaatt   1740

gcaggagagg aaaagagagt gtattacgtg catgactttg atgcattgaa agacataaga   1800

aaccaagttg ttcaagaaat ctgtactgaa gaagcttgca aagagatgaa agctgacatc   1860

atgtttctgg tggacagttc tggaagtata ggacctgaaa acttcagcaa aatgaaaaca   1920

tttatgaaaa acctggtgag caagtctcag attggaccag atcgggtgca aattggtgta   1980

gtccagttca gcgacatcaa taaggaagag tttcagctca acagattcat gtcccaaagc   2040

gacatttcaa atgcaataga ccaaatggct cacattggac aaaccaccct gactggtagt   2100

gccctgagct ttgtgtctca gtacttcagc cccaccaagg gcgcccggcc caacatcaga   2160

aagtttctca tcctcatcac ggatggtgaa gctcaggaca tagtaaagga accagcagta   2220

gtgcttcggc aagaaggtgt aatcatctat tctgtgggag tgtttggctc caatgtcacc   2280

cagcttgagg agatcagtgg gaggcccgag atggtttttt atgttgagaa ttttgacatt   2340

ctgcagcgca ttgaagatga tcttgttttt ggaatatgca gcccccgtga agaatgcaag   2400

cggattgaag ttttagacgt tgtgtttgtc attgatagct ctggcagtat tgactatgat   2460

gagtataata tcatgaagga ttttatgatt ggcttagtga aaaaagctga tgtgggcaag   2520

aatcaggtcc ggtttggggc tctgaagtat gctgatgacc cagaggtgct gttttatctg   2580

gatgactttg gcacaaaact ggaggtaatt tcagtgctcc agaatgacca agccatgggt   2640

ggcagtactt atactgctga ggcactgggc ttctcagacc acatgttcac tgaagcccgg   2700

ggcagccgcc tgaacaaggg ggtcccccaa gtcctcattg tgatcaccga tggggaatcc   2760

catgatgctg ataaactcaa tgccacggca aaggccttgc gggacaaagg cattcttgtc   2820

ctggctgtgg ggattgatgg tgccaatccc gtggagctgt tagccatggc aggatcaagc   2880

gacaagtact tcttcgtgga gacttttgga ggtctgaagg gaatattttc agatgtgaca   2940

gccagtgtct gcaactcttc aaaagtagat tgtgaaattg acaaagtaga tcttgttttc   3000

cttatggatg gttcaactag cattcagcca aatgacttca agaaaatgaa ggaatttctg   3060

gcatctgttg ttcaagactt tgatgtcagc ctcaacagag tgcgaatagg agcggcccag   3120

tttagcgata cctatcaccc ggagtttcca ctgggaactt tcataggtga aaaagagata   3180

tcatttcaga ttgaaaacat caagcagatc tttggaaaca cacacatcgg tgctgcactc   3240

agggaggtgg aacattactt caggccagac atgggcagca ggataaatac aggtacccca   3300

caggtgctgc tggtccttac agatggccag tcccaagacg aggtggccca ggccgcggaa   3360

gccctgagac acagaggtat cgacatctac tccgtgggca ttggggatgt ggatgaccag   3420

cagctcattc agatcaccgg gactgcagag aaaaaactga cagtgcacaa cttcgatgaa   3480

ctgaagaagg tcaataaaag gatcgttcgc aacatctgta ccacagcggg tgaaagcagt   3540

gtgaggaaaa ggccattgtt tgcaatctgg ctggtttcag aggttgaaga gcaatgcctc   3600

aaagaaagga aatatttgac tgatttttgg ttgcttggca atacggccta tagggctgcc   3660

aagagctgtg gtacagactg tttcgtggat gttgtggtgg gatttgatgt ctcaactcag   3720

gagaaagggc agactttgct tgaaggtcag ccttggatgg aaacctacct tcaagacatc   3780

ttacgtgcca tcagctccct caatggagta agctgtgagg tgggcacaga gactcaggtc   3840

agtgtggctt ttcaagtgac caatgccatg gaaaaatatt ctcccaagtt tgagatctac   3900

agtgaaaaca tactgaatag cttgaaggat ataacagtta aaggaccatc tcttctcaat   3960

gcaaacctct tggattctct atgggataca tttcagaata aatcagctgc tcgaggaaag   4020

gtggtccttt tattttcaga tggattggat gatgatgttg agaaacttga acaaaaatct   4080

gatgaactta gaaaagaagg cctgaatgcc ctcataactg ttgctctgga tggacctgct   4140

gattcaagtg acttggctga tcttccctat attgaatttg ggaaaggatt tgagtacagg   4200

acacagctct ctattggcat gagagaactt ggaagccggc tgtcaaagca gctggtcaat   4260

gttgctgaaa ggacatgctg ctgtttgttc tgcaagtgca ttggaggaga tggcacaatg   4320

ggagatcctg gaccaccagg gaaaaggctt catgtaaaga gagtggtaga tttttttaaa   4380

aaacaaggct cagaaagaat ggaaagaaag ggacctccag gttttaaagg cagtgaaggc   4440

tacctgggag aggagggaat cgctggagaa agaggagccc ctggaccagt gggagagcaa   4500

ggtactaagg gatgctatgg caccaaaggt cctaagggaa acagaggact aaatggacag   4560

gagggagaag ttggggaaaa tggaattgac ggattaaacg gagaacaggg tgataatggt   4620

cttcctggaa gaaaaggaga aaagggagat gagggatctc agggaagccc agggaagaga   4680

gggactcctg gtgaccgtgg agcaaagggc ctgcgagggg atcccgtaag tgcacgggct   4740

gcaaactgga gttagggctt gattcccatc cgtacttctg atagggagtc tcgatttcaa   4800

gggagctcct ggagttgaca gtagcataga aggacccaca ggcttgaaag gagaacgtgg   4860

aagacaaggc agaagaggct ggccaggccc ccccgggaca ccaggctcca gaagaaagac   4920

agcagctcat ggcagaaggg gacatacagg cccacaggga acagcaggca tcccaggacc   4980

agatggactt gaaggctccc tgggacttaa gggccctcag ggcccaagag gagaggctgg   5040

tgtgaaagga gaaaaaggag gtgtgggaag taaaggtccc caggggcctc caggacccgg   5100

aggagaggca gggaatcaag gccgtttggg aagccaagga aataaaggag aacctggaga   5160

tctgggagaa aaaggagctg ttggctttcc tggtcctcgt ggcttgcagg gcaatgatgg   5220

cagtccaggt tatggtagtg tcggacgcaa gggagcaaag ggacaagaag gattccctgg   5280

agaaagtgga cctaagggtg agattgggga ccctggtggt ccaggagaga ctgggctgaa   5340

gggagctaga ggcaaaatga tatctgctgg gcttccagga gagatgggat cccctgggga   5400

accaggacct cctggacgta agggtgtgaa aggagccaaa ggcttggctt cattttctac   5460

atgtgagctc attcagtatg tgcgagaccg cagtcctggc aggcatgatt gacgacactg   5520

gcacatttca agtaatagtg gttccctccg gggccgacta cataccagca ttagagagac   5580

tccagcggtg cactttctgc tatgatgtgt gcaagccaga tgcttcttgt gaccaagcca   5640

gaccaccccc tgtgcagtct tacatggatg ctgctttcct tctggatgcc tcccggaaca   5700

tgggaagtgc tgaatttgaa gacataagag ccttccttgg agcactatta gatcactttg   5760

aaatcacccc agagccggag acttctgtca ctggagaccg ggtggcccta ttgagccatg   5820

ctccccccga cttcctaccc aacactcaga agagtccagt tagagctgag ttcaatctta   5880

ccacctacag aagtaagcgc ctcatgaaga ggcatgtgca cgagtcagtt aaacaactaa   5940

atggagatgc ttttattggt catgccttac agtggactct ggacaatgta tttttaagta   6000

cacccaatct gagaagaaac aaagtcatat ttgtgatatc tgctggggaa accagccact   6060

tagatgggga aatcttaaag aaggaatcct tgcgagccaa atgtcaggga tatgccttat   6120

ttgtgttttc ccttggccct atttgggatg acaaggaact ggaggatctc gccagccacc   6180

ctttggatca ccacctggtc cagcttggcc gaattcataa acctgaccac agttatggtg   6240

tgaagtttgt gaagtccttt ataaactcaa tcaggcgtgc aatcaacaaa tatccaccaa   6300

taaacttaaa aataaagtgc aacagactta actctataga tccaaagcag cccccacgac   6360

cattccgaag ctttgttcct ggaccactta aagctaccct caaagaagat gtattacaga   6420

aggcaaaatt ctttcaagat aaaaaatatc tttcaagagt agcaagaagt ggcagagatg   6480

atgctattca aaattttatg agaagcacct cccatacctt taagaatgga aggatgatag   6540

aaagtgctcc caaacaacat gattaaaaaa atgcttgaac aacttagcct taggaagcat   6600

ggtaagactc tggacttaaa tagtaactaa atctgctgcc agaactcaag caacagtttg   6660

taggttatca ggtgacttga ccccctgcat tcattggtat taagatatat cttgttcatt   6720

tatttgacca ctcctgacaa ttccagcact ctacgactga tatgtcgaag aactgtttca   6780

ttagaagaca gaagaatgaa agaagtgttt tgaaaagtct aatggagata taatttgaag   6840

gtaaaattta tatgatgtat gcatatgtgt acatgggtca atgttaattc ttttatctct   6900

gtccagttca ttttctgcaa acccatcctc ctttcctaat ttagtaatgt ctaatgctca   6960

tctatttagt caaagttatt ttttaatgtt ttaagctact ccaaaattta tcctagaaat   7020

ggatgctgtt tatatgtcgt atttttttaa aacgtgacct tctattccac ttaaacacac   7080

cactgtggga gttgtttgct tggactgatg agaagagggt aattttctcc atctctaaat   7140

cctcctgaac tcactgaaaa actcattaat tcccgcagaa cataaattat tgcttttgag   7200

ctggaagttt tctcttcatt aggaagctta ctgccatttt gatggagctt gaagccccca   7260

ttttgatgga cttctagtct gtctttcctg ttatggtcat ttattaattt tcactaatcc   7320

atatattctt tagacaagga gagtcaagaa actacttgtc atagatgaag ctctgagtta   7380

cttttaccca tcaggtagct gtttagtcaa taataaacag caccaaaaca ggattagcag   7440

agctcttaaa aacagcctta aatacacact gagtttagaa aaatgtaaga aaatcattgt   7500

tttaatctac aaattcatat gcagttgcag agatgcaaaa gagatcagag taagttaaag   7560

taggaaaggt tttataaaag tattgatggc tgtgtcctca tctgcatttt tgtttttatg   7620

atagggctga tattttcaac aacgaaacac ccaatgttca gaccttacct cagtctaaga   7680

gctggctcca cagttggtag caatggccct gttaggcaga ctgtccccct ctttgggaat   7740

ggaaagaagc cctgcctgga tgcatggagc agatggatac tgacaccaag gacattcaga   7800

ttttctttcc tatacctatt ttcataaaat ttggaaagaa aaactatctg cagtattttt   7860

ttaaaacgac ttctgctatt cttacttaga gaaatccagt gatagcacct catgtcttca   7920

gaggagcaag aagttcaagg agttaaatgt cacattcata ctcaggtaat agagaagaat   7980

aaaacacatc aggtttgctt catctatcct aagtggtgct taggggttca gaaaaaatgt   8040

ttcaagtaca ggaaattaat gagcaatatt tacaatgtat tttaataaaa gggatttttc   8100

tagttaactc tgagttaagc acgaactcct ttcttttgtt aattgttgga aataccatta   8160

agatgtattt gtctgttttt ctgcattggc aa                                 8192


<210>  9804
<211>  1584
<212>  PRT
<213>  Homosapiens

<400>  9804

Met Ala Val Asn Phe Leu Lys Phe Leu Val Arg Ser Tyr Val Cys Gly 
1               5                   10                  15      


Phe Ala Gly Pro Glu Tyr Ala Asp Val Val Phe Leu Val Asp Ser Ser 
            20                  25                  30          


Asp Arg Leu Gly Ser Lys Ser Phe Pro Phe Val Lys Met Phe Ile Thr 
        35                  40                  45              


Lys Met Ile Ser Ser Leu Pro Ile Glu Ala Asp Lys Tyr Arg Val Ala 
    50                  55                  60                  


Leu Ala Gln Tyr Ser Asp Lys Leu His Ser Glu Phe His Leu Ser Thr 
65                  70                  75                  80  


Phe Lys Gly Arg Ser Pro Met Leu Asn His Leu Arg Lys Asn Phe Gly 
                85                  90                  95      


Phe Ile Gly Gly Ser Leu Gln Ile Gly Lys Ala Leu Gln Glu Ala His 
            100                 105                 110         


Arg Thr Tyr Phe Ser Ala Pro Ala Asn Gly Arg Asp Lys Lys Gln Phe 
        115                 120                 125             


Pro Pro Ile Leu Val Val Leu Ala Ser Ser Glu Ser Glu Asp Asn Val 
    130                 135                 140                 


Glu Glu Ala Ser Lys Ala Leu Arg Lys Asp Gly Val Lys Ile Ile Ser 
145                 150                 155                 160 


Val Gly Val Gln Lys Ala Ser Glu Glu Asn Leu Lys Ala Met Ala Thr 
                165                 170                 175     


Ser Gln Phe His Phe Asn Leu Arg Thr Val Arg Asp Leu Ser Met Phe 
            180                 185                 190         


Ser Gln Asn Met Thr His Ile Ile Lys Asp Val Ile Lys Tyr Lys Glu 
        195                 200                 205             


Gly Ala Val Asp Asp Ile Phe Val Glu Ala Cys Gln Gly Pro Ser Met 
    210                 215                 220                 


Ala Asp Val Val Phe Leu Leu Asp Met Ser Ile Asn Gly Ser Glu Glu 
225                 230                 235                 240 


Asn Phe Asp Tyr Leu Lys Gly Phe Leu Glu Glu Ser Val Ser Ala Leu 
                245                 250                 255     


Asp Ile Lys Glu Asn Cys Met Arg Val Gly Leu Val Ala Tyr Ser Asn 
            260                 265                 270         


Glu Thr Lys Val Ile Asn Ser Leu Ser Met Gly Ile Asn Lys Ser Glu 
        275                 280                 285             


Val Leu Gln His Ile Gln Asn Leu Ser Pro Arg Thr Gly Lys Ala Tyr 
    290                 295                 300                 


Thr Gly Ala Ala Ile Lys Lys Leu Arg Lys Glu Val Phe Ser Ala Arg 
305                 310                 315                 320 


Asn Gly Ser Arg Lys Asn Gln Gly Val Pro Gln Ile Ala Val Leu Val 
                325                 330                 335     


Thr His Arg Asp Ser Glu Asp Asn Val Thr Lys Ala Ala Val Asn Leu 
            340                 345                 350         


Arg Arg Glu Gly Val Thr Ile Phe Thr Leu Gly Ile Glu Gly Ala Ser 
        355                 360                 365             


Asp Thr Gln Leu Glu Lys Ile Ala Ser His Pro Ala Glu Gln Tyr Val 
    370                 375                 380                 


Ser Lys Leu Lys Thr Phe Ala Asp Leu Ala Ala His Asn Gln Thr Phe 
385                 390                 395                 400 


Leu Lys Lys Leu Arg Asn Gln Ile Thr His Thr Val Ser Val Phe Ser 
                405                 410                 415     


Glu Arg Thr Glu Thr Leu Lys Ser Gly Cys Val Asp Thr Glu Glu Ala 
            420                 425                 430         


Asp Ile Tyr Leu Leu Ile Asp Gly Ser Gly Ser Thr Gln Ala Thr Asp 
        435                 440                 445             


Phe His Glu Met Lys Thr Phe Leu Ser Glu Val Val Gly Met Phe Asn 
    450                 455                 460                 


Ile Ala Pro His Lys Val Arg Val Gly Ala Val Gln Tyr Ala Asp Ser 
465                 470                 475                 480 


Trp Asp Leu Glu Phe Glu Ile Asn Lys Tyr Ser Asn Lys Gln Asp Leu 
                485                 490                 495     


Gly Lys Ala Ile Glu Asn Ile Arg Gln Met Gly Gly Asn Thr Asn Thr 
            500                 505                 510         


Gly Ala Ala Leu Asn Phe Thr Leu Ser Leu Leu Gln Lys Ala Lys Lys 
        515                 520                 525             


Gln Arg Gly Asn Lys Val Pro Cys His Leu Val Val Leu Thr Asn Gly 
    530                 535                 540                 


Met Ser Lys Asp Ser Ile Leu Glu Pro Ala Asn Arg Leu Arg Glu Glu 
545                 550                 555                 560 


His Ile Arg Val Tyr Ala Ile Gly Ile Lys Glu Ala Asn Gln Thr Gln 
                565                 570                 575     


Leu Arg Glu Ile Ala Gly Glu Glu Lys Arg Val Tyr Tyr Val His Asp 
            580                 585                 590         


Phe Asp Ala Leu Lys Asp Ile Arg Asn Gln Val Val Gln Glu Ile Cys 
        595                 600                 605             


Thr Glu Glu Ala Cys Lys Glu Met Lys Ala Asp Ile Met Phe Leu Val 
    610                 615                 620                 


Asp Ser Ser Gly Ser Ile Gly Pro Glu Asn Phe Ser Lys Met Lys Thr 
625                 630                 635                 640 


Phe Met Lys Asn Leu Val Ser Lys Ser Gln Ile Gly Pro Asp Arg Val 
                645                 650                 655     


Gln Ile Gly Val Val Gln Phe Ser Asp Ile Asn Lys Glu Glu Phe Gln 
            660                 665                 670         


Leu Asn Arg Phe Met Ser Gln Ser Asp Ile Ser Asn Ala Ile Asp Gln 
        675                 680                 685             


Met Ala His Ile Gly Gln Thr Thr Leu Thr Gly Ser Ala Leu Ser Phe 
    690                 695                 700                 


Val Ser Gln Tyr Phe Ser Pro Thr Lys Gly Ala Arg Pro Asn Ile Arg 
705                 710                 715                 720 


Lys Phe Leu Ile Leu Ile Thr Asp Gly Glu Ala Gln Asp Ile Val Lys 
                725                 730                 735     


Glu Pro Ala Val Val Leu Arg Gln Glu Gly Val Ile Ile Tyr Ser Val 
            740                 745                 750         


Gly Val Phe Gly Ser Asn Val Thr Gln Leu Glu Glu Ile Ser Gly Arg 
        755                 760                 765             


Pro Glu Met Val Phe Tyr Val Glu Asn Phe Asp Ile Leu Gln Arg Ile 
    770                 775                 780                 


Glu Asp Asp Leu Val Phe Gly Ile Cys Ser Pro Arg Glu Glu Cys Lys 
785                 790                 795                 800 


Arg Ile Glu Val Leu Asp Val Val Phe Val Ile Asp Ser Ser Gly Ser 
                805                 810                 815     


Ile Asp Tyr Asp Glu Tyr Asn Ile Met Lys Asp Phe Met Ile Gly Leu 
            820                 825                 830         


Val Lys Lys Ala Asp Val Gly Lys Asn Gln Val Arg Phe Gly Ala Leu 
        835                 840                 845             


Lys Tyr Ala Asp Asp Pro Glu Val Leu Phe Tyr Leu Asp Asp Phe Gly 
    850                 855                 860                 


Thr Lys Leu Glu Val Ile Ser Val Leu Gln Asn Asp Gln Ala Met Gly 
865                 870                 875                 880 


Gly Ser Thr Tyr Thr Ala Glu Ala Leu Gly Phe Ser Asp His Met Phe 
                885                 890                 895     


Thr Glu Ala Arg Gly Ser Arg Leu Asn Lys Gly Val Pro Gln Val Leu 
            900                 905                 910         


Ile Val Ile Thr Asp Gly Glu Ser His Asp Ala Asp Lys Leu Asn Ala 
        915                 920                 925             


Thr Ala Lys Ala Leu Arg Asp Lys Gly Ile Leu Val Leu Ala Val Gly 
    930                 935                 940                 


Ile Asp Gly Ala Asn Pro Val Glu Leu Leu Ala Met Ala Gly Ser Ser 
945                 950                 955                 960 


Asp Lys Tyr Phe Phe Val Glu Thr Phe Gly Gly Leu Lys Gly Ile Phe 
                965                 970                 975     


Ser Asp Val Thr Ala Ser Val Cys Asn Ser Ser Lys Val Asp Cys Glu 
            980                 985                 990         


Ile Asp Lys Val Asp Leu Val Phe  Leu Met Asp Gly Ser  Thr Ser Ile 
        995                 1000                 1005             


Gln Pro  Asn Asp Phe Lys Lys  Met Lys Glu Phe Leu  Ala Ser Val 
    1010                 1015                 1020             


Val Gln  Asp Phe Asp Val Ser  Leu Asn Arg Val Arg  Ile Gly Ala 
    1025                 1030                 1035             


Ala Gln  Phe Ser Asp Thr Tyr  His Pro Glu Phe Pro  Leu Gly Thr 
    1040                 1045                 1050             


Phe Ile  Gly Glu Lys Glu Ile  Ser Phe Gln Ile Glu  Asn Ile Lys 
    1055                 1060                 1065             


Gln Ile  Phe Gly Asn Thr His  Ile Gly Ala Ala Leu  Arg Glu Val 
    1070                 1075                 1080             


Glu His  Tyr Phe Arg Pro Asp  Met Gly Ser Arg Ile  Asn Thr Gly 
    1085                 1090                 1095             


Thr Pro  Gln Val Leu Leu Val  Leu Thr Asp Gly Gln  Ser Gln Asp 
    1100                 1105                 1110             


Glu Val  Ala Gln Ala Ala Glu  Ala Leu Arg His Arg  Gly Ile Asp 
    1115                 1120                 1125             


Ile Tyr  Ser Val Gly Ile Gly  Asp Val Asp Asp Gln  Gln Leu Ile 
    1130                 1135                 1140             


Gln Ile  Thr Gly Thr Ala Glu  Lys Lys Leu Thr Val  His Asn Phe 
    1145                 1150                 1155             


Asp Glu  Leu Lys Lys Val Asn  Lys Arg Ile Val Arg  Asn Ile Cys 
    1160                 1165                 1170             


Thr Thr  Ala Gly Glu Ser Ser  Val Arg Lys Arg Pro  Leu Phe Ala 
    1175                 1180                 1185             


Ile Trp  Leu Val Ser Glu Val  Glu Glu Gln Cys Leu  Lys Glu Arg 
    1190                 1195                 1200             


Lys Tyr  Leu Thr Asp Phe Trp  Leu Leu Gly Asn Thr  Ala Tyr Arg 
    1205                 1210                 1215             


Ala Ala  Lys Ser Cys Gly Thr  Asp Cys Phe Val Asp  Val Val Val 
    1220                 1225                 1230             


Gly Phe  Asp Val Ser Thr Gln  Glu Lys Gly Gln Thr  Leu Leu Glu 
    1235                 1240                 1245             


Gly Gln  Pro Trp Met Glu Thr  Tyr Leu Gln Asp Ile  Leu Arg Ala 
    1250                 1255                 1260             


Ile Ser  Ser Leu Asn Gly Val  Ser Cys Glu Val Gly  Thr Glu Thr 
    1265                 1270                 1275             


Gln Val  Ser Val Ala Phe Gln  Val Thr Asn Ala Met  Glu Lys Tyr 
    1280                 1285                 1290             


Ser Pro  Lys Phe Glu Ile Tyr  Ser Glu Asn Ile Leu  Asn Ser Leu 
    1295                 1300                 1305             


Lys Asp  Ile Thr Val Lys Gly  Pro Ser Leu Leu Asn  Ala Asn Leu 
    1310                 1315                 1320             


Leu Asp  Ser Leu Trp Asp Thr  Phe Gln Asn Lys Ser  Ala Ala Arg 
    1325                 1330                 1335             


Gly Lys  Val Val Leu Leu Phe  Ser Asp Gly Leu Asp  Asp Asp Val 
    1340                 1345                 1350             


Glu Lys  Leu Glu Gln Lys Ser  Asp Glu Leu Arg Lys  Glu Gly Leu 
    1355                 1360                 1365             


Asn Ala  Leu Ile Thr Val Ala  Leu Asp Gly Pro Ala  Asp Ser Ser 
    1370                 1375                 1380             


Asp Leu  Ala Asp Leu Pro Tyr  Ile Glu Phe Gly Lys  Gly Phe Glu 
    1385                 1390                 1395             


Tyr Arg  Thr Gln Leu Ser Ile  Gly Met Arg Glu Leu  Gly Ser Arg 
    1400                 1405                 1410             


Leu Ser  Lys Gln Leu Val Asn  Val Ala Glu Arg Thr  Cys Cys Cys 
    1415                 1420                 1425             


Leu Phe  Cys Lys Cys Ile Gly  Gly Asp Gly Thr Met  Gly Asp Pro 
    1430                 1435                 1440             


Gly Pro  Pro Gly Lys Arg Leu  His Val Lys Arg Val  Val Asp Phe 
    1445                 1450                 1455             


Phe Lys  Lys Gln Gly Ser Glu  Arg Met Glu Arg Lys  Gly Pro Pro 
    1460                 1465                 1470             


Gly Phe  Lys Gly Ser Glu Gly  Tyr Leu Gly Glu Glu  Gly Ile Ala 
    1475                 1480                 1485             


Gly Glu  Arg Gly Ala Pro Gly  Pro Val Gly Glu Gln  Gly Thr Lys 
    1490                 1495                 1500             


Gly Cys  Tyr Gly Thr Lys Gly  Pro Lys Gly Asn Arg  Gly Leu Asn 
    1505                 1510                 1515             


Gly Gln  Glu Gly Glu Val Gly  Glu Asn Gly Ile Asp  Gly Leu Asn 
    1520                 1525                 1530             


Gly Glu  Gln Gly Asp Asn Gly  Leu Pro Gly Arg Lys  Gly Glu Lys 
    1535                 1540                 1545             


Gly Asp  Glu Gly Ser Gln Gly  Ser Pro Gly Lys Arg  Gly Thr Pro 
    1550                 1555                 1560             


Gly Asp  Arg Gly Ala Lys Gly  Leu Arg Gly Asp Pro  Val Ser Ala 
    1565                 1570                 1575             


Arg Ala  Ala Asn Trp Ser 
    1580                 


<210>  9805
<211>  4106
<212>  DNA
<213>  Homosapiens

<400>  9805
ggatgatgat gttgagaaac ttgaacaaaa atctgatgaa cttagaaaag aaggcctgaa     60

tgccctcata actgttgctc tggatggacc tgctgattca agtgacttgg ctgatcttcc    120

ctatattgaa tttgggaaag gatttgagta caggacacag ctctctattg gcatgagaga    180

acttggaagc cggctgtcaa agcagctggt caatgttgct gaaaggacat gctgctgttt    240

gttctgcaag tgcattggag gagatggcac aatgggagat cctggaccac cagggaaaag    300

gggacctcca ggttttaaag gcagtgaagg ctacctggga gaggagggaa tcgctggaga    360

aagaggagcc cctggaccag tgggagagca aggtactaag ggatgctatg gcaccaaagg    420

tcctaaggga aacagaggac taaatggaca ggagggagaa gttggggaaa atggaattga    480

cggattaaac ggagaacagg gtgataatgg tcttcctgga agaaaaggag aaaagggaga    540

tgagggatct cagggaagcc cagggaagag agggactcct ggtgaccgtg gagcaaaggg    600

cctgcgaggg gatcccgtaa gtgcacgggc tgcaaactgg agttagggct tgattcccat    660

ccgtacttct gatagggagt ctcgatttca agggagctcc tggagttgac agtagcatag    720

aaggacccac aggcttgaaa ggagaacgtg gaagacaagg cagaagaggc tggccaggcc    780

cccccgggac accaggctcc agaagaaaga cagcagctca tggcagaagg ggacatacag    840

gcccacaggg aacagcaggc atcccaggac cagatggact tgaaggctcc ctgggactta    900

agggccctca gggcccaaga ggagaggctg gtgtgaaagg agaaaaagga ggtgtgggaa    960

gtaaaggtcc ccaggggcct ccaggacccg gaggagaggc agggaatcaa ggccgtttgg   1020

gaagccaagg aaataaagga gaacctggag atctgggaga aaaaggagct gttggctttc   1080

ctggtcctcg tggcttgcag ggcaatgatg gcagtccagg ttatggtagt gtcggacgca   1140

agggagcaaa gggacaagaa ggattccctg gagaaagtgg acctaagggt gagattgggg   1200

accctggtgg tccaggagag actgggctga agggagctag aggcaaaatg atatctgctg   1260

ggcttccagg agagatggga tcccctgggg aaccaggacc tcctggacgt aagggtgtga   1320

aaggagccaa aggcttggct tcattttcta catgtgagct cattcagtat gtgcgagacc   1380

gcagtcctgg caggcatgat tgacgacact ggcacatttc aagtaatagt ggttccctcc   1440

ggggccgact acataccagc attagagaga ctccagcggt gcactttctg ctatgatgtg   1500

tgcaagccag atgcttcttg tgaccaagcc agaccacccc ctgtgcagtc ttacatggat   1560

gctgctttcc ttctggatgc ctcccggaac atgggaagtg ctgaatttga agacataaga   1620

gccttccttg gagcactatt agatcacttt gaaatcaccc cagagccgga gacttctgtc   1680

actggagacc gggtggccct attgagccat gctccccccg acttcctacc caacactcag   1740

aagagtccag ttagagctga gttcaatctt accacctaca gaagtaagcg cctcatgaag   1800

aggcatgtgc acgagtcagt taaacaacta aatggagatg cttttattgg tcatgcctta   1860

cagtggactc tggacaatgt atttttaagt acacccaatc tgagaagaaa caaagtcata   1920

tttgtgatat ctgctgggga aaccagccac ttagatgggg aaatcttaaa gaaggaatcc   1980

ttgcgagcca aatgtcaggg atatgcctta tttgtgtttt cccttggccc tatttgggat   2040

gacaaggaac tggaggatct cgccagccac cctttggatc accacctggt ccagcttggc   2100

cgaattcata aacctgacca cagttatggt gtgaagtttg tgaagtcctt tataaactca   2160

atcaggcgtg caatcaacaa atatccacca ataaacttaa aaataaagtg caacagactt   2220

aactctatag atccaaagca gcccccacga ccattccgaa gctttgttcc tggaccactt   2280

aaagctaccc tcaaagaaga tgtattacag aaggcaaaat tctttcaaga taaaaaatat   2340

ctttcaagag tagcaagaag tggcagagat gatgctattc aaaattttat gagaagcacc   2400

tcccatacct ttaagaatgg aaggatgata gaaagtgctc ccaaacaaca tgattaaaaa   2460

aatgcttgaa caacttagcc ttaggaagca tggtaagact ctggacttaa atagtaacta   2520

aatctgctgc cagaactcaa gcaacagttt gtaggttatc aggtgacttg accccctgca   2580

ttcattggta ttaagatata tcttgttcat ttatttgacc actcctgaca attccagcac   2640

tctacgactg atatgtcgaa gaactgtttc attagaagac agaagaatga aagaagtgtt   2700

ttgaaaagtc taatggagat ataatttgaa ggtaaaattt atatgatgta tgcatatgtg   2760

tacatgggtc aatgttaatt cttttatctc tgtccagttc attttctgca aacccatcct   2820

cctttcctaa tttagtaatg tctaatgctc atctatttag tcaaagttat tttttaatgt   2880

tttaagctac tccaaaattt atcctagaaa tggatgctgt ttatatgtcg tattttttta   2940

aaacgtgacc ttctattcca cttaaacaca ccactgtggg agttgtttgc ttggactgat   3000

gagaagaggg taattttctc catctctaaa tcctcctgaa ctcactgaaa aactcattaa   3060

ttcccgcaga acataaatta ttgcttttga gctggaagtt ttctcttcat taggaagctt   3120

actgccattt tgatggagct tgaagccccc attttgatgg acttctagtc tgtctttcct   3180

gttatggtca tttattaatt ttcactaatc catatattct ttagacaagg agagtcaaga   3240

aactacttgt catagatgaa gctctgagtt acttttaccc atcaggtagc tgtttagtca   3300

ataataaaca gcaccaaaac aggattagca gagctcttaa aaacagcctt aaatacacac   3360

tgagtttaga aaaatgtaag aaaatcattg ttttaatcta caaattcata tgcagttgca   3420

gagatgcaaa agagatcaga gtaagttaaa gtaggaaagg ttttataaaa gtattgatgg   3480

ctgtgtcctc atctgcattt ttgtttttat gatagggctg atattttcaa caacgaaaca   3540

cccaatgttc agaccttacc tcagtctaag agctggctcc acagttggta gcaatggccc   3600

tgttaggcag actgtccccc tctttgggaa tggaaagaag ccctgcctgg atgcatggag   3660

cagatggata ctgacaccaa ggacattcag attttctttc ctatacctat tttcataaaa   3720

tttggaaaga aaaactatct gcagtatttt tttaaaacga cttctgctat tcttacttag   3780

agaaatccag tgatagcacc tcatgtcttc agaggagcaa gaagttcaag gagttaaatg   3840

tcacattcat actcaggtaa tagagaagaa taaaacacat caggtttgct tcatctatcc   3900

taagtggtgc ttaggggttc agaaaaaatg tttcaagtac aggaaattaa tgagcaatat   3960

ttacaatgta ttttaataaa agggattttt ctagttaact ctgagttaag cacgaactcc   4020

tttcttttgt taattgttgg aaataccatt aagatgtatt tgtctgtttt tctgcattgg   4080

caagtaaaga acataaaaca aatatt                                        4106


<210>  9806
<211>  362
<212>  PRT
<213>  Homosapiens

<400>  9806

Met Cys Glu Thr Ala Val Leu Ala Gly Met Ile Asp Asp Thr Gly Thr 
1               5                   10                  15      


Phe Gln Val Ile Val Val Pro Ser Gly Ala Asp Tyr Ile Pro Ala Leu 
            20                  25                  30          


Glu Arg Leu Gln Arg Cys Thr Phe Cys Tyr Asp Val Cys Lys Pro Asp 
        35                  40                  45              


Ala Ser Cys Asp Gln Ala Arg Pro Pro Pro Val Gln Ser Tyr Met Asp 
    50                  55                  60                  


Ala Ala Phe Leu Leu Asp Ala Ser Arg Asn Met Gly Ser Ala Glu Phe 
65                  70                  75                  80  


Glu Asp Ile Arg Ala Phe Leu Gly Ala Leu Leu Asp His Phe Glu Ile 
                85                  90                  95      


Thr Pro Glu Pro Glu Thr Ser Val Thr Gly Asp Arg Val Ala Leu Leu 
            100                 105                 110         


Ser His Ala Pro Pro Asp Phe Leu Pro Asn Thr Gln Lys Ser Pro Val 
        115                 120                 125             


Arg Ala Glu Phe Asn Leu Thr Thr Tyr Arg Ser Lys Arg Leu Met Lys 
    130                 135                 140                 


Arg His Val His Glu Ser Val Lys Gln Leu Asn Gly Asp Ala Phe Ile 
145                 150                 155                 160 


Gly His Ala Leu Gln Trp Thr Leu Asp Asn Val Phe Leu Ser Thr Pro 
                165                 170                 175     


Asn Leu Arg Arg Asn Lys Val Ile Phe Val Ile Ser Ala Gly Glu Thr 
            180                 185                 190         


Ser His Leu Asp Gly Glu Ile Leu Lys Lys Glu Ser Leu Arg Ala Lys 
        195                 200                 205             


Cys Gln Gly Tyr Ala Leu Phe Val Phe Ser Leu Gly Pro Ile Trp Asp 
    210                 215                 220                 


Asp Lys Glu Leu Glu Asp Leu Ala Ser His Pro Leu Asp His His Leu 
225                 230                 235                 240 


Val Gln Leu Gly Arg Ile His Lys Pro Asp His Ser Tyr Gly Val Lys 
                245                 250                 255     


Phe Val Lys Ser Phe Ile Asn Ser Ile Arg Arg Ala Ile Asn Lys Tyr 
            260                 265                 270         


Pro Pro Ile Asn Leu Lys Ile Lys Cys Asn Arg Leu Asn Ser Ile Asp 
        275                 280                 285             


Pro Lys Gln Pro Pro Arg Pro Phe Arg Ser Phe Val Pro Gly Pro Leu 
    290                 295                 300                 


Lys Ala Thr Leu Lys Glu Asp Val Leu Gln Lys Ala Lys Phe Phe Gln 
305                 310                 315                 320 


Asp Lys Lys Tyr Leu Ser Arg Val Ala Arg Ser Gly Arg Asp Asp Ala 
                325                 330                 335     


Ile Gln Asn Phe Met Arg Ser Thr Ser His Thr Phe Lys Asn Gly Arg 
            340                 345                 350         


Met Ile Glu Ser Ala Pro Lys Gln His Asp 
        355                 360         


<210>  9807
<211>  5016
<212>  DNA
<213>  Homosapiens

<400>  9807
gaggtcagac cggttgcttt cccgggagtt cggcgtttgc tggggctgca gcagctgaag     60

tgtagtgttt tcttgggact ggcggtctgc acttctctcc cgggttccat ctccccccgc    120

ccggtggtga ggccctcgag gagggctcgg acgggtgtag cgatccgcgc tagaggaaga    180

cgaggcccgg gaacgcatgt cccccagggc aggttagggg gctggagggg tcaaatcccg    240

gggtacttgt ggagactctt tagcgtggct tcttctctct gctgagaccc cgagagcttt    300

cccagttctc ctcccaggac caccggggtt cctgaagatc gggacttttc tgcgcccctc    360

caccaacagc ccatctcctg tctatgaaga aagacccttc gtagaaacaa cttccccgct    420

gctgacgcgt tttcccgtcc cgtccccgaa gtagtctact atgacctcgt tgtgagcctc    480

tgaacgattt tgacactttc ccgaggccta gggtattata tcctaacctt actaaagacc    540

acagaggtgc ttgccattat gggaaatcag cttgctggca ttgctccctc ccagatcctt    600

tctgtagaga gttatttttc agatattcat gactttgaat atgataaaag cctggggagt    660

actcggtttt ttaaagttgc tcgagccaag caccgagaag gcctggtcgt tgtgaaggtt    720

tttgcaattc aggatcccac attgccttta accagctata aacaagagct ggaggaactg    780

aaaatcaggc ttaattctgc acagaattgt ctacctttcc agaaagcatc agaaaaagca    840

tctgagaaag cagctatgct ctttaggcag tatgtgcgag acaatctcta tgatcgcatc    900

agtacccgtc cattcttgaa taacattgag aagcgctgga ttgctttcca gatcctgaca    960

gctgtggacc aagcacacaa atctggagtt cgtcatgggg acatcaagac tgagaatgtg   1020

atggtcacca gttggaattg ggttcttcta actgattttg ccagttttaa gcccacttat   1080

cttccagaag acaacccggc agatttcaat tatttctttg acacatcacg gaggagaact   1140

tgctatattg ctcctgaacg ttttgttgat ggtgggatgt ttgccactga gttagaatat   1200

atgagagatc cttcaactcc gcttgtagac ttaaatagca atcagagaac aagaggagag   1260

ttgaagagag caatggacat cttttcagca ggttgtgtga tagctgagct ttttacagaa   1320

ggtgtaccat tatttgatct ctctcaactt ttggcttata gaaatggaca ttttttccct   1380

gaacaagtgc taaataaaat tgaagatcac agtatcagag aattggtaac tcagatgatt   1440

caccgtgagc cagataaacg tttagaggca gaagattact taaaacagca gcgtggcaat   1500

gcctttcctg aaatatttta cacttttctt cagccctaca tggcccagtt tgccaaggaa   1560

acgtttcttt ctgcagatga gcgtattctg gttatacgga aggatttggg caacattatt   1620

cacaatctct gtggacatga tctgccagaa aaagccgaag gagagcctaa ggaaaatggg   1680

ctggttatct tggtatctgt tataacatcc tgcctacaga cccttaaata ctgtgattcc   1740

aaactagctg ctttggaact gattcttcat ttggctccaa gattaagtgt tgaaatcctt   1800

ttggatcgta ttactccata tcttttgcat ttcagcaatg actctgttcc tagggtgagg   1860

gctgaagcct tgaggacgtt gaccaaagtt cttgctctcg tcaaagaggt tcctcgtaat   1920

gatatcaata tttatccgga atacattctg ccaggcatag cccacttagc ccaagatgat   1980

gctactatcg ttagactagc ctatgctgaa aacatagctc tgctggcaga aacagctctg   2040

agattcctgg aattagtaca gttaaaaaat cttaatatgg aaaatgaccc caataatgaa   2100

gaaatagatg aggttacaca tccaaatgga aattatgaca cagagctcca agccttacat   2160

gaaatggtcc agcagaaagt tgttactttg ctaagtgacc ctgaaaatat tgtaaaacaa   2220

accttgatgg aaaatggaat aacacggctg tgtgtattct ttggacgtca gaaagccaac   2280

gatgttttgt tgtcccacat gattactttc ctaaatgata agaatgattg gcatctacgt   2340

ggagcatttt ttgatagtat agttggtgtt gctgcctatg ttggctggca aagctcctca   2400

attctcaagc ctctgctgca acaaggtctt agtgatgctg aggaatttgt cattgtgaaa   2460

gctctttatg cccttacttg tatgtgccag ttaggactgc tacaaaaacc ccatgtttac   2520

gaatttgcca gtgatattgc ccccttcctg tgtcatccca atttatggat acgttatggt   2580

gccgtgggat ttatcacagt ggtagctcgt caaataagta cagctgatgt ctactgtaaa   2640

ctgatgcctt atcttgaccc atatattacc caaccaataa tacagattga aagaaaactt   2700

gttctgctca gtgttttaaa ggaaccagta agtcgttcta tatttgatta tgctttgagg   2760

tctaaagata ttactagctt gttcagacat cttcacatgc gtcagaagaa acgaaatggt   2820

tctcttcccg actgccctcc gccagaggat cctgccatag cacagcttct gaagaagttg   2880

ctctcacagg gaatgacaga ggaagaggaa gacaaacttc tggcactgaa agacttcatg   2940

atgaaatcta ataaagcaaa ggccaatata gtggaccaga gccatcttca tgatagtagt   3000

cagaaaggtg taattgactt ggcagcttta ggcataactg ggagacaagt tgatcttgtt   3060

aaaaccaaac aagaaccaga tgacaaacgg gccagaaaac atgtaaaaca agactcaaat   3120

gtaaatgaag aatggaaaag catgtttggg tcactggacc caccaaacat gccacaggcc   3180

ctacctaaag ggagtgatca ggaggtgatt cagactggga aacctcctcg ttccgagtcc   3240

tctgctggca tttgtgtccc tttgtcaact tcttcacagg ttccagaagt gacaactgtc   3300

caaaataaaa aaccagtaat accggtttta agtagtacaa tcttaccatc cacctatcag   3360

attcgaatta caacttgtaa aactgaactt cagcaactca tccagcaaaa gcgggagcag   3420

tgcaatgctg agagaatagc taagcagatg atggaaaatg ctgaatggga gagtaaacca   3480

ccaccacctg gatggcgtcc taaagggctg ttagttgccc atcttcatga gcataaatct   3540

gctgtgaatc gaattagagt ctctgatgaa cactcacttt ttgcaacatg ttcaaatgat   3600

ggcacagtga aaatctggaa cagtcaaaag atggagggga agaccaccac taccagatct   3660

attcttacat acagccgaat tggaggacga gtcaagacgc tcacattctg ccaaggctcc   3720

cactatttag ccatagcatc tgataatggt gctgtccagc ttcttggaat tgaggcttct   3780

aagctgccca agtctcctaa aatccatcct ctacaaagca gaattctaga tcagaaggag   3840

gacggttgtg ttgtggatat gcatcacttc aactctggag cacagtctgt tcttgcctat   3900

gccactgtga atggctctct ggttggctgg gaccttaggt cttcaagcaa tgcgtggact   3960

ttaaagcatg atttaaagtc gggcctcatc acttcctttg ctgtggacat ccaccaatgc   4020

tggctctgca ttggtacaag cagtggtacc atggcttgtt gggacatgag gttccagttg   4080

ccaatttcaa gtcactgtca tccttccagg gctcgaatca gacgcctctc aatgcaccct   4140

ctgtatcagt cctgggtgat tgcagctgtt cagggcaaca acgaagtgtc catgtgggac   4200

atggagactg gtgacagaag atttactctc tgggccagca gtgcaccacc actttctgaa   4260

ttacagcctt ctcctcatag cgtccatggt atctactgta gtcctgcaga tggaaatcct   4320

atcctactaa cagctggctc agatatgaaa ataaggtttt gggacttggc ttacccagaa   4380

aggtcctatg ttgttgcagg aagtactagt tccccatctg tgtcctacta caggaaaata   4440

attgaaggca ctgaagttgt ccaggaaatt cagaataagc agaaagtagg accaagtgat   4500

gacacccctc gaaggggccc agagtccctg cccgtgggac atcatgacat catcactgat   4560

gtcgccacat tccagaccac acagggcttc atcgtaactg cttctagaga tgggattgtg   4620

aaggtgtgga aataaaacct actgatttgt ataaatttta atagttataa atataatact   4680

ataactcgag aaaaggcatt tctagagaac agattcattt gcttaatttt caaaattatg   4740

tctccatatt actgtttcat gactgactga ctaaatgaca cccaaaatgg ttaagatgta   4800

cttgactagt ttacttatgc atctctttgc aagaatcagc cagccaacaa tgtctgggat   4860

ttttattgta tatgttatag aggtgagaaa tgtaaaatat gaaaatgaat atgtttattt   4920

tgtattgaaa aagatggttg aaaagatggt tgtaagctat tatagtataa acacattttt   4980

gctattaaaa atgctattca aagcagttaa actgta                             5016


<210>  9808
<211>  1358
<212>  PRT
<213>  Homosapiens

<400>  9808

Met Gly Asn Gln Leu Ala Gly Ile Ala Pro Ser Gln Ile Leu Ser Val 
1               5                   10                  15      


Glu Ser Tyr Phe Ser Asp Ile His Asp Phe Glu Tyr Asp Lys Ser Leu 
            20                  25                  30          


Gly Ser Thr Arg Phe Phe Lys Val Ala Arg Ala Lys His Arg Glu Gly 
        35                  40                  45              


Leu Val Val Val Lys Val Phe Ala Ile Gln Asp Pro Thr Leu Pro Leu 
    50                  55                  60                  


Thr Ser Tyr Lys Gln Glu Leu Glu Glu Leu Lys Ile Arg Leu Asn Ser 
65                  70                  75                  80  


Ala Gln Asn Cys Leu Pro Phe Gln Lys Ala Ser Glu Lys Ala Ser Glu 
                85                  90                  95      


Lys Ala Ala Met Leu Phe Arg Gln Tyr Val Arg Asp Asn Leu Tyr Asp 
            100                 105                 110         


Arg Ile Ser Thr Arg Pro Phe Leu Asn Asn Ile Glu Lys Arg Trp Ile 
        115                 120                 125             


Ala Phe Gln Ile Leu Thr Ala Val Asp Gln Ala His Lys Ser Gly Val 
    130                 135                 140                 


Arg His Gly Asp Ile Lys Thr Glu Asn Val Met Val Thr Ser Trp Asn 
145                 150                 155                 160 


Trp Val Leu Leu Thr Asp Phe Ala Ser Phe Lys Pro Thr Tyr Leu Pro 
                165                 170                 175     


Glu Asp Asn Pro Ala Asp Phe Asn Tyr Phe Phe Asp Thr Ser Arg Arg 
            180                 185                 190         


Arg Thr Cys Tyr Ile Ala Pro Glu Arg Phe Val Asp Gly Gly Met Phe 
        195                 200                 205             


Ala Thr Glu Leu Glu Tyr Met Arg Asp Pro Ser Thr Pro Leu Val Asp 
    210                 215                 220                 


Leu Asn Ser Asn Gln Arg Thr Arg Gly Glu Leu Lys Arg Ala Met Asp 
225                 230                 235                 240 


Ile Phe Ser Ala Gly Cys Val Ile Ala Glu Leu Phe Thr Glu Gly Val 
                245                 250                 255     


Pro Leu Phe Asp Leu Ser Gln Leu Leu Ala Tyr Arg Asn Gly His Phe 
            260                 265                 270         


Phe Pro Glu Gln Val Leu Asn Lys Ile Glu Asp His Ser Ile Arg Glu 
        275                 280                 285             


Leu Val Thr Gln Met Ile His Arg Glu Pro Asp Lys Arg Leu Glu Ala 
    290                 295                 300                 


Glu Asp Tyr Leu Lys Gln Gln Arg Gly Asn Ala Phe Pro Glu Ile Phe 
305                 310                 315                 320 


Tyr Thr Phe Leu Gln Pro Tyr Met Ala Gln Phe Ala Lys Glu Thr Phe 
                325                 330                 335     


Leu Ser Ala Asp Glu Arg Ile Leu Val Ile Arg Lys Asp Leu Gly Asn 
            340                 345                 350         


Ile Ile His Asn Leu Cys Gly His Asp Leu Pro Glu Lys Ala Glu Gly 
        355                 360                 365             


Glu Pro Lys Glu Asn Gly Leu Val Ile Leu Val Ser Val Ile Thr Ser 
    370                 375                 380                 


Cys Leu Gln Thr Leu Lys Tyr Cys Asp Ser Lys Leu Ala Ala Leu Glu 
385                 390                 395                 400 


Leu Ile Leu His Leu Ala Pro Arg Leu Ser Val Glu Ile Leu Leu Asp 
                405                 410                 415     


Arg Ile Thr Pro Tyr Leu Leu His Phe Ser Asn Asp Ser Val Pro Arg 
            420                 425                 430         


Val Arg Ala Glu Ala Leu Arg Thr Leu Thr Lys Val Leu Ala Leu Val 
        435                 440                 445             


Lys Glu Val Pro Arg Asn Asp Ile Asn Ile Tyr Pro Glu Tyr Ile Leu 
    450                 455                 460                 


Pro Gly Ile Ala His Leu Ala Gln Asp Asp Ala Thr Ile Val Arg Leu 
465                 470                 475                 480 


Ala Tyr Ala Glu Asn Ile Ala Leu Leu Ala Glu Thr Ala Leu Arg Phe 
                485                 490                 495     


Leu Glu Leu Val Gln Leu Lys Asn Leu Asn Met Glu Asn Asp Pro Asn 
            500                 505                 510         


Asn Glu Glu Ile Asp Glu Val Thr His Pro Asn Gly Asn Tyr Asp Thr 
        515                 520                 525             


Glu Leu Gln Ala Leu His Glu Met Val Gln Gln Lys Val Val Thr Leu 
    530                 535                 540                 


Leu Ser Asp Pro Glu Asn Ile Val Lys Gln Thr Leu Met Glu Asn Gly 
545                 550                 555                 560 


Ile Thr Arg Leu Cys Val Phe Phe Gly Arg Gln Lys Ala Asn Asp Val 
                565                 570                 575     


Leu Leu Ser His Met Ile Thr Phe Leu Asn Asp Lys Asn Asp Trp His 
            580                 585                 590         


Leu Arg Gly Ala Phe Phe Asp Ser Ile Val Gly Val Ala Ala Tyr Val 
        595                 600                 605             


Gly Trp Gln Ser Ser Ser Ile Leu Lys Pro Leu Leu Gln Gln Gly Leu 
    610                 615                 620                 


Ser Asp Ala Glu Glu Phe Val Ile Val Lys Ala Leu Tyr Ala Leu Thr 
625                 630                 635                 640 


Cys Met Cys Gln Leu Gly Leu Leu Gln Lys Pro His Val Tyr Glu Phe 
                645                 650                 655     


Ala Ser Asp Ile Ala Pro Phe Leu Cys His Pro Asn Leu Trp Ile Arg 
            660                 665                 670         


Tyr Gly Ala Val Gly Phe Ile Thr Val Val Ala Arg Gln Ile Ser Thr 
        675                 680                 685             


Ala Asp Val Tyr Cys Lys Leu Met Pro Tyr Leu Asp Pro Tyr Ile Thr 
    690                 695                 700                 


Gln Pro Ile Ile Gln Ile Glu Arg Lys Leu Val Leu Leu Ser Val Leu 
705                 710                 715                 720 


Lys Glu Pro Val Ser Arg Ser Ile Phe Asp Tyr Ala Leu Arg Ser Lys 
                725                 730                 735     


Asp Ile Thr Ser Leu Phe Arg His Leu His Met Arg Gln Lys Lys Arg 
            740                 745                 750         


Asn Gly Ser Leu Pro Asp Cys Pro Pro Pro Glu Asp Pro Ala Ile Ala 
        755                 760                 765             


Gln Leu Leu Lys Lys Leu Leu Ser Gln Gly Met Thr Glu Glu Glu Glu 
    770                 775                 780                 


Asp Lys Leu Leu Ala Leu Lys Asp Phe Met Met Lys Ser Asn Lys Ala 
785                 790                 795                 800 


Lys Ala Asn Ile Val Asp Gln Ser His Leu His Asp Ser Ser Gln Lys 
                805                 810                 815     


Gly Val Ile Asp Leu Ala Ala Leu Gly Ile Thr Gly Arg Gln Val Asp 
            820                 825                 830         


Leu Val Lys Thr Lys Gln Glu Pro Asp Asp Lys Arg Ala Arg Lys His 
        835                 840                 845             


Val Lys Gln Asp Ser Asn Val Asn Glu Glu Trp Lys Ser Met Phe Gly 
    850                 855                 860                 


Ser Leu Asp Pro Pro Asn Met Pro Gln Ala Leu Pro Lys Gly Ser Asp 
865                 870                 875                 880 


Gln Glu Val Ile Gln Thr Gly Lys Pro Pro Arg Ser Glu Ser Ser Ala 
                885                 890                 895     


Gly Ile Cys Val Pro Leu Ser Thr Ser Ser Gln Val Pro Glu Val Thr 
            900                 905                 910         


Thr Val Gln Asn Lys Lys Pro Val Ile Pro Val Leu Ser Ser Thr Ile 
        915                 920                 925             


Leu Pro Ser Thr Tyr Gln Ile Arg Ile Thr Thr Cys Lys Thr Glu Leu 
    930                 935                 940                 


Gln Gln Leu Ile Gln Gln Lys Arg Glu Gln Cys Asn Ala Glu Arg Ile 
945                 950                 955                 960 


Ala Lys Gln Met Met Glu Asn Ala Glu Trp Glu Ser Lys Pro Pro Pro 
                965                 970                 975     


Pro Gly Trp Arg Pro Lys Gly Leu Leu Val Ala His Leu His Glu His 
            980                 985                 990         


Lys Ser Ala Val Asn Arg Ile Arg  Val Ser Asp Glu His  Ser Leu Phe 
        995                 1000                 1005             


Ala Thr  Cys Ser Asn Asp Gly  Thr Val Lys Ile Trp  Asn Ser Gln 
    1010                 1015                 1020             


Lys Met  Glu Gly Lys Thr Thr  Thr Thr Arg Ser Ile  Leu Thr Tyr 
    1025                 1030                 1035             


Ser Arg  Ile Gly Gly Arg Val  Lys Thr Leu Thr Phe  Cys Gln Gly 
    1040                 1045                 1050             


Ser His  Tyr Leu Ala Ile Ala  Ser Asp Asn Gly Ala  Val Gln Leu 
    1055                 1060                 1065             


Leu Gly  Ile Glu Ala Ser Lys  Leu Pro Lys Ser Pro  Lys Ile His 
    1070                 1075                 1080             


Pro Leu  Gln Ser Arg Ile Leu  Asp Gln Lys Glu Asp  Gly Cys Val 
    1085                 1090                 1095             


Val Asp  Met His His Phe Asn  Ser Gly Ala Gln Ser  Val Leu Ala 
    1100                 1105                 1110             


Tyr Ala  Thr Val Asn Gly Ser  Leu Val Gly Trp Asp  Leu Arg Ser 
    1115                 1120                 1125             


Ser Ser  Asn Ala Trp Thr Leu  Lys His Asp Leu Lys  Ser Gly Leu 
    1130                 1135                 1140             


Ile Thr  Ser Phe Ala Val Asp  Ile His Gln Cys Trp  Leu Cys Ile 
    1145                 1150                 1155             


Gly Thr  Ser Ser Gly Thr Met  Ala Cys Trp Asp Met  Arg Phe Gln 
    1160                 1165                 1170             


Leu Pro  Ile Ser Ser His Cys  His Pro Ser Arg Ala  Arg Ile Arg 
    1175                 1180                 1185             


Arg Leu  Ser Met His Pro Leu  Tyr Gln Ser Trp Val  Ile Ala Ala 
    1190                 1195                 1200             


Val Gln  Gly Asn Asn Glu Val  Ser Met Trp Asp Met  Glu Thr Gly 
    1205                 1210                 1215             


Asp Arg  Arg Phe Thr Leu Trp  Ala Ser Ser Ala Pro  Pro Leu Ser 
    1220                 1225                 1230             


Glu Leu  Gln Pro Ser Pro His  Ser Val His Gly Ile  Tyr Cys Ser 
    1235                 1240                 1245             


Pro Ala  Asp Gly Asn Pro Ile  Leu Leu Thr Ala Gly  Ser Asp Met 
    1250                 1255                 1260             


Lys Ile  Arg Phe Trp Asp Leu  Ala Tyr Pro Glu Arg  Ser Tyr Val 
    1265                 1270                 1275             


Val Ala  Gly Ser Thr Ser Ser  Pro Ser Val Ser Tyr  Tyr Arg Lys 
    1280                 1285                 1290             


Ile Ile  Glu Gly Thr Glu Val  Val Gln Glu Ile Gln  Asn Lys Gln 
    1295                 1300                 1305             


Lys Val  Gly Pro Ser Asp Asp  Thr Pro Arg Arg Gly  Pro Glu Ser 
    1310                 1315                 1320             


Leu Pro  Val Gly His His Asp  Ile Ile Thr Asp Val  Ala Thr Phe 
    1325                 1330                 1335             


Gln Thr  Thr Gln Gly Phe Ile  Val Thr Ala Ser Arg  Asp Gly Ile 
    1340                 1345                 1350             


Val Lys  Val Trp Lys 
    1355             


<210>  9809
<211>  3301
<212>  DNA
<213>  Homosapiens

<400>  9809
gaggtcagac cggttgcttt cccgggagtt cggcgtttgc tggggctgca gcagctgaag     60

tgtagtgttt tcttgggact ggcggtctgc acttctctcc cgggttccat ctccccccgc    120

ccggtggtga ggccctcgag gagggctcgg acgggtgtag cgatccgcgc tagaggaaga    180

cgaggcccgg gaacgcatgt cccccagggc aggttagggg gctggagggg tcaaatcccg    240

gggtacttgt ggagactctt tagcgtggct tcttctctct gctgagaccc cgagagcttt    300

cccagttctc ctcccaggac caccggggtt cctgaagatc gggacttttc tgcgcccctc    360

caccaacagc ccatctcctg tctatgaaga aagacccttc gtagaaacaa cttccccgct    420

gctgacgcgt tttcccgtcc cgtccccgaa gtagtctact atgacctcgt tgtgagcctc    480

tgaacgattt tgacactttc ccgaggccta gggtattata tcctaacctt actaaagacc    540

acagaggtgc ttgccattat gggaaatcag cttgctggca ttgctccctc ccagatcctt    600

tctgtagaga gttatttttc agatattcat gactttgaat atgataaaag cctggggagt    660

actcggtttt ttaaagttgc tcgagccaag caccgagaag gcctggtcgt tgtgaaggtt    720

tttgcaattc aggatcccac attgccttta accagctata aacaagagct ggaggaactg    780

aaaatcaggc ttaattctgc acagaattgt ctacctttcc agaaagcatc agaaaaagca    840

tctgagaaag cagctatgct ctttaggcag tatgtgcgag acaatctcta tgatcgcatc    900

agtacccgtc cattcttgaa taacattgag aagcgctgga ttgctttcca gatcctgaca    960

gctgtggacc aagcacacaa atctggagtt cgtcatgggg acatcaagac tgagaatgtg   1020

atggtcacca gttggaattg ggttcttcta actgattttg ccagttttaa gcccacttat   1080

cttccagaag acaacccggc agatttcaat tatttctttg acacatcacg gaggagaact   1140

tgctatattg ctcctgaacg ttttgttgat ggtgggatgt ttgccactga gttagaatat   1200

atgagagatc cttcaactcc gcttgtagac ttaaatagca atcagagaac aagaggagag   1260

ttgaagagag caatggacat cttttcagca ggttgtgtga tagctgagct ttttacagaa   1320

ggtgtaccat tatttgatct ctctcaactt ttggcttata gaaatggaca ttttttccct   1380

gaacaagtgc taaataaaat tgaagatcac agtatcagag aattggtaac tcagatgatt   1440

caccgtgagc cagataaacg tttagaggca gaagattact taaaacagca gcgtggcaat   1500

gcctttcctg aaatatttta cacttttctt cagccctaca tggcccagtt tgccaaggaa   1560

acgtttcttt ctgcagatga gcgtattctg gttatacgga aggatttggg caacattatt   1620

cacaatctct gtggacatga tctgccagaa aaagccgaag gagagcctaa ggaaaatggg   1680

ctggttatct tggtatctgt tataacatcc tgcctacaga cccttaaata ctgtgattcc   1740

aaactagctg ctttggaact gattcttcat ttggctccaa gattaagtgt tgaaatcctt   1800

ttggatcgta ttactccata tcttttgcat ttcagcaatg actctgttcc tagggtgagg   1860

gctgaagcct tgaggacgtt gaccaaagtt cttgctctcg tcaaagaggt tcctcgtaat   1920

gatatcaata tttatccgga atacattctg ccaggcatag cccacttagc ccaagatgat   1980

gctactatcg ttagactagc ctatgctgaa aacatagctc tgctggcaga aacagctctg   2040

agattcctgg aattagtaca gttaaaaaat cttaatatgg aaaatgaccc caataatgaa   2100

gaaatagatg aggttacaca tccaaatgga aattatgaca cagagctcca agccttacat   2160

gaaatggtcc agcagaaagt tgttactttg ctaagtgacc ctgaaaatat tgtaaaacaa   2220

accttgatgg aaaatggaat aacacggctg tgtgtattct ttggacgtca gaaagccaac   2280

gatgttttgt tgtcccacat gattactttc ctaaatgata agaatgattg gcatctacgt   2340

ggagcatttt ttgatagtat agttggtgtt gctgcctatg ttggctggca aagctcctca   2400

attctcaagc ctctgctgca acaaggtctt agtgatgctg aggaatttgt cattgtgaaa   2460

gctctttatg cccttacttg tatgtgccag ttaggactgc tacaaaaacc ccatgtttac   2520

gaatttgcca gtgatattgc ccccttcctg tgtcatccca atttatggat acgttatggt   2580

gccgtgggat ttatcacagt ggtagctcgt caaataagta cagctgatgt ctactgtaaa   2640

ctgatgcctt atcttgaccc atatattacc caaccaataa tacagattga aagaaaactt   2700

gttctgctca gtgttttaaa ggaaccagta agtcgttcta tatttgatta tgctttgagg   2760

tctaaagata ttactagctt gttcagacat cttcacatgc gtcagaagaa acgaaatggt   2820

tctcttcccg actgccctcc gccagaggat cctgccatag cacagcttct gaagaagttg   2880

ctctcacagg gaatgacaga ggaagaggaa gacaaacttc tggcactgaa agacttcatg   2940

atgaaatcta ataaagcaaa ggccaatata gtggaccaga gccatcttca tgatagtagt   3000

cagaaaggtg taattgactt ggcagcttta ggcataactg ggagacaagt tgatcttgtt   3060

aaaaccaaac aagaaccaga tgacaaacgg gccagaaaac atgtaaaaca agactcaaat   3120

gtaaatgaag aatggaaaag catgtttggg tcactggacc caccaaacat gccacaggcc   3180

ctacctaaag ggagtgatca ggaggtgatt cagactggga aacctcctcg ttccgagtcc   3240

tctgctggca tttgtgtccc tttgtcaact tcttcacagg ttccagaagt gacaactgtc   3300

c                                                                   3301


<210>  9810
<211>  913
<212>  PRT
<213>  Homosapiens

<400>  9810

Met Gly Asn Gln Leu Ala Gly Ile Ala Pro Ser Gln Ile Leu Ser Val 
1               5                   10                  15      


Glu Ser Tyr Phe Ser Asp Ile His Asp Phe Glu Tyr Asp Lys Ser Leu 
            20                  25                  30          


Gly Ser Thr Arg Phe Phe Lys Val Ala Arg Ala Lys His Arg Glu Gly 
        35                  40                  45              


Leu Val Val Val Lys Val Phe Ala Ile Gln Asp Pro Thr Leu Pro Leu 
    50                  55                  60                  


Thr Ser Tyr Lys Gln Glu Leu Glu Glu Leu Lys Ile Arg Leu Asn Ser 
65                  70                  75                  80  


Ala Gln Asn Cys Leu Pro Phe Gln Lys Ala Ser Glu Lys Ala Ser Glu 
                85                  90                  95      


Lys Ala Ala Met Leu Phe Arg Gln Tyr Val Arg Asp Asn Leu Tyr Asp 
            100                 105                 110         


Arg Ile Ser Thr Arg Pro Phe Leu Asn Asn Ile Glu Lys Arg Trp Ile 
        115                 120                 125             


Ala Phe Gln Ile Leu Thr Ala Val Asp Gln Ala His Lys Ser Gly Val 
    130                 135                 140                 


Arg His Gly Asp Ile Lys Thr Glu Asn Val Met Val Thr Ser Trp Asn 
145                 150                 155                 160 


Trp Val Leu Leu Thr Asp Phe Ala Ser Phe Lys Pro Thr Tyr Leu Pro 
                165                 170                 175     


Glu Asp Asn Pro Ala Asp Phe Asn Tyr Phe Phe Asp Thr Ser Arg Arg 
            180                 185                 190         


Arg Thr Cys Tyr Ile Ala Pro Glu Arg Phe Val Asp Gly Gly Met Phe 
        195                 200                 205             


Ala Thr Glu Leu Glu Tyr Met Arg Asp Pro Ser Thr Pro Leu Val Asp 
    210                 215                 220                 


Leu Asn Ser Asn Gln Arg Thr Arg Gly Glu Leu Lys Arg Ala Met Asp 
225                 230                 235                 240 


Ile Phe Ser Ala Gly Cys Val Ile Ala Glu Leu Phe Thr Glu Gly Val 
                245                 250                 255     


Pro Leu Phe Asp Leu Ser Gln Leu Leu Ala Tyr Arg Asn Gly His Phe 
            260                 265                 270         


Phe Pro Glu Gln Val Leu Asn Lys Ile Glu Asp His Ser Ile Arg Glu 
        275                 280                 285             


Leu Val Thr Gln Met Ile His Arg Glu Pro Asp Lys Arg Leu Glu Ala 
    290                 295                 300                 


Glu Asp Tyr Leu Lys Gln Gln Arg Gly Asn Ala Phe Pro Glu Ile Phe 
305                 310                 315                 320 


Tyr Thr Phe Leu Gln Pro Tyr Met Ala Gln Phe Ala Lys Glu Thr Phe 
                325                 330                 335     


Leu Ser Ala Asp Glu Arg Ile Leu Val Ile Arg Lys Asp Leu Gly Asn 
            340                 345                 350         


Ile Ile His Asn Leu Cys Gly His Asp Leu Pro Glu Lys Ala Glu Gly 
        355                 360                 365             


Glu Pro Lys Glu Asn Gly Leu Val Ile Leu Val Ser Val Ile Thr Ser 
    370                 375                 380                 


Cys Leu Gln Thr Leu Lys Tyr Cys Asp Ser Lys Leu Ala Ala Leu Glu 
385                 390                 395                 400 


Leu Ile Leu His Leu Ala Pro Arg Leu Ser Val Glu Ile Leu Leu Asp 
                405                 410                 415     


Arg Ile Thr Pro Tyr Leu Leu His Phe Ser Asn Asp Ser Val Pro Arg 
            420                 425                 430         


Val Arg Ala Glu Ala Leu Arg Thr Leu Thr Lys Val Leu Ala Leu Val 
        435                 440                 445             


Lys Glu Val Pro Arg Asn Asp Ile Asn Ile Tyr Pro Glu Tyr Ile Leu 
    450                 455                 460                 


Pro Gly Ile Ala His Leu Ala Gln Asp Asp Ala Thr Ile Val Arg Leu 
465                 470                 475                 480 


Ala Tyr Ala Glu Asn Ile Ala Leu Leu Ala Glu Thr Ala Leu Arg Phe 
                485                 490                 495     


Leu Glu Leu Val Gln Leu Lys Asn Leu Asn Met Glu Asn Asp Pro Asn 
            500                 505                 510         


Asn Glu Glu Ile Asp Glu Val Thr His Pro Asn Gly Asn Tyr Asp Thr 
        515                 520                 525             


Glu Leu Gln Ala Leu His Glu Met Val Gln Gln Lys Val Val Thr Leu 
    530                 535                 540                 


Leu Ser Asp Pro Glu Asn Ile Val Lys Gln Thr Leu Met Glu Asn Gly 
545                 550                 555                 560 


Ile Thr Arg Leu Cys Val Phe Phe Gly Arg Gln Lys Ala Asn Asp Val 
                565                 570                 575     


Leu Leu Ser His Met Ile Thr Phe Leu Asn Asp Lys Asn Asp Trp His 
            580                 585                 590         


Leu Arg Gly Ala Phe Phe Asp Ser Ile Val Gly Val Ala Ala Tyr Val 
        595                 600                 605             


Gly Trp Gln Ser Ser Ser Ile Leu Lys Pro Leu Leu Gln Gln Gly Leu 
    610                 615                 620                 


Ser Asp Ala Glu Glu Phe Val Ile Val Lys Ala Leu Tyr Ala Leu Thr 
625                 630                 635                 640 


Cys Met Cys Gln Leu Gly Leu Leu Gln Lys Pro His Val Tyr Glu Phe 
                645                 650                 655     


Ala Ser Asp Ile Ala Pro Phe Leu Cys His Pro Asn Leu Trp Ile Arg 
            660                 665                 670         


Tyr Gly Ala Val Gly Phe Ile Thr Val Val Ala Arg Gln Ile Ser Thr 
        675                 680                 685             


Ala Asp Val Tyr Cys Lys Leu Met Pro Tyr Leu Asp Pro Tyr Ile Thr 
    690                 695                 700                 


Gln Pro Ile Ile Gln Ile Glu Arg Lys Leu Val Leu Leu Ser Val Leu 
705                 710                 715                 720 


Lys Glu Pro Val Ser Arg Ser Ile Phe Asp Tyr Ala Leu Arg Ser Lys 
                725                 730                 735     


Asp Ile Thr Ser Leu Phe Arg His Leu His Met Arg Gln Lys Lys Arg 
            740                 745                 750         


Asn Gly Ser Leu Pro Asp Cys Pro Pro Pro Glu Asp Pro Ala Ile Ala 
        755                 760                 765             


Gln Leu Leu Lys Lys Leu Leu Ser Gln Gly Met Thr Glu Glu Glu Glu 
    770                 775                 780                 


Asp Lys Leu Leu Ala Leu Lys Asp Phe Met Met Lys Ser Asn Lys Ala 
785                 790                 795                 800 


Lys Ala Asn Ile Val Asp Gln Ser His Leu His Asp Ser Ser Gln Lys 
                805                 810                 815     


Gly Val Ile Asp Leu Ala Ala Leu Gly Ile Thr Gly Arg Gln Val Asp 
            820                 825                 830         


Leu Val Lys Thr Lys Gln Glu Pro Asp Asp Lys Arg Ala Arg Lys His 
        835                 840                 845             


Val Lys Gln Asp Ser Asn Val Asn Glu Glu Trp Lys Ser Met Phe Gly 
    850                 855                 860                 


Ser Leu Asp Pro Pro Asn Met Pro Gln Ala Leu Pro Lys Gly Ser Asp 
865                 870                 875                 880 


Gln Glu Val Ile Gln Thr Gly Lys Pro Pro Arg Ser Glu Ser Ser Ala 
                885                 890                 895     


Gly Ile Cys Val Pro Leu Ser Thr Ser Ser Gln Val Pro Glu Val Thr 
            900                 905                 910         


Thr 
    


<210>  9811
<211>  2675
<212>  DNA
<213>  Homosapiens

<400>  9811
gaggtcagac cggttgcttt cccgggagtt cggcgtttgc tggggctgca gcagctgaag     60

tgtagtgttt tcttgggact ggcggtctgc acttctctcc cgggttccat ctccccccgc    120

ccggtggtga ggccctcgag gagggctcgg acgggtgtag cgatccgcgc tagaggaaga    180

cgaggcccgg gaacgcatgt cccccagggc aggttagggg gctggagggg tcaaatcccg    240

gggtacttgt ggagactctt tagcgtggct tcttctctct gctgagaccc cgagagcttt    300

cccagttctc ctcccaggac caccggggtt cctgaagatc gggacttttc tgcgcccctc    360

caccaacagc ccatctcctg tctatgaaga aagacccttc gtagaaacaa cttccccgct    420

gctgacgcgt tttcccgtcc cgtccccgaa gtagtctact atgacctcgt tgtgagcctc    480

tgaacgattt tgacactttc ccgaggccta gggtattata tcctaacctt actaaagacc    540

acagaggtgc ttgccattat gggaaatcag cttgctggca ttgctccctc ccagatcctt    600

tctgtagaga gttatttttc agatattcat gactttgaat atgataaaag cctggggagt    660

actcggtttt ttaaagttgc tcgagccaag caccgagaag gcctggtcgt tgtgaaggtt    720

tttgcaattc aggatcccac attgccttta accagctata aacaagagct ggaggaactg    780

aaaatcaggc ttaattctgc acagaattgt ctacctttcc agaaagcatc agaaaaagca    840

tctgagaaag cagctatgct ctttaggcag tatgtgcgag acaatctcta tgatcgcatc    900

agtacccgtc cattcttgaa taacattgag aagcgctgga ttgctttcca gatcctgaca    960

gctgtggacc aagcacacaa atctggagtt cgtcatgggg acatcaagac tgagaatgtg   1020

atggtcacca gttggaattg ggttcttcta actgattttg ccagttttaa gcccacttat   1080

cttccagaag acaacccggc agatttcaat tatttctttg acacatcacg gaggagaact   1140

tgctatattg ctcctgaacg ttttgttgat ggtgggatgt ttgccactga gttagaatat   1200

atgagagatc cttcaactcc gcttgtagac ttaaatagca atcagagaac aagaggagag   1260

ttgaagagag caatggacat cttttcagca ggttgtgtga tagctgagct ttttacagaa   1320

ggtgtaccat tatttgatct ctctcaactt ttggcttata gaaatggaca ttttttccct   1380

gaacaagtgc taaataaaat tgaagatcac agtatcagag aattggtaac tcagatgatt   1440

caccgtgagc cagataaacg tttagaggca gaagattact taaaacagca gcgtggcaat   1500

gcctttcctg aaatatttta cacttttctt cagccctaca tggcccagtt tgccaaggaa   1560

acgtttcttt ctgcagatga gcgtattctg gttatacgga aggatttggg caacattatt   1620

cacaatctct gtggacatga tctgccagaa aaagccgaag gagagcctaa ggaaaatggg   1680

ctggttatct tggtatctgt tataacatcc tgcctacaga cccttaaata ctgtgattcc   1740

aaactagctg ctttggaact gattcttcat ttggctccaa gattaagtgt tgaaatcctt   1800

ttggatcgta ttactccata tcttttgcat ttcagcaatg actctgttcc tagggtgagg   1860

gctgaagcct tgaggacgtt gaccaaagtt cttgctctcg tcaaagaggt tcctcgtaat   1920

gatatcaata tttatccgga atacattctg ccaggcatag cccacttagc ccaagatgat   1980

gctactatcg ttagactagc ctatgctgaa aacatagctc tgctggcaga aacagctctg   2040

agattcctgg aattagtaca gttaaaaaat cttaatatgg aaaatgaccc caataatgaa   2100

gaaatagatg aggttacaca tccaaatgga aattatgaca cagagctcca agccttacat   2160

gaaatggtcc agcagaaagt tgttactttg ctaagtgacc ctgaaaatat tgtaaaacaa   2220

accttgatgg aaaatggaat aacacggctg tgtgtattct ttggacgtca gaaagccaac   2280

gatgttttgt tgtcccacat gattactttc ctaaatgata agaatgattg gcatctacgt   2340

ggagcatttt ttgatagtat agttggtgtt gctgcctatg ttggctggca aagctcctca   2400

attctcaagc ctctgctgca acaaggtctt agtgatgctg aggaatttgt cattgtgaaa   2460

gctctttatg cccttacttg tatgtgccag ttaggactgc tacaaaaacc ccatgtttac   2520

gaatttgcca gtgatattgc ccccttcctg tgtcatccca atttatggat acgttatggt   2580

gccgtgggat ttatcacagt ggtagctcgt caaataagta cagctgatgt ctactgtaaa   2640

ctgatgcctt atcttgaccc atatattacc caacc                              2675


<210>  9812
<211>  704
<212>  PRT
<213>  Homosapiens

<400>  9812

Met Gly Asn Gln Leu Ala Gly Ile Ala Pro Ser Gln Ile Leu Ser Val 
1               5                   10                  15      


Glu Ser Tyr Phe Ser Asp Ile His Asp Phe Glu Tyr Asp Lys Ser Leu 
            20                  25                  30          


Gly Ser Thr Arg Phe Phe Lys Val Ala Arg Ala Lys His Arg Glu Gly 
        35                  40                  45              


Leu Val Val Val Lys Val Phe Ala Ile Gln Asp Pro Thr Leu Pro Leu 
    50                  55                  60                  


Thr Ser Tyr Lys Gln Glu Leu Glu Glu Leu Lys Ile Arg Leu Asn Ser 
65                  70                  75                  80  


Ala Gln Asn Cys Leu Pro Phe Gln Lys Ala Ser Glu Lys Ala Ser Glu 
                85                  90                  95      


Lys Ala Ala Met Leu Phe Arg Gln Tyr Val Arg Asp Asn Leu Tyr Asp 
            100                 105                 110         


Arg Ile Ser Thr Arg Pro Phe Leu Asn Asn Ile Glu Lys Arg Trp Ile 
        115                 120                 125             


Ala Phe Gln Ile Leu Thr Ala Val Asp Gln Ala His Lys Ser Gly Val 
    130                 135                 140                 


Arg His Gly Asp Ile Lys Thr Glu Asn Val Met Val Thr Ser Trp Asn 
145                 150                 155                 160 


Trp Val Leu Leu Thr Asp Phe Ala Ser Phe Lys Pro Thr Tyr Leu Pro 
                165                 170                 175     


Glu Asp Asn Pro Ala Asp Phe Asn Tyr Phe Phe Asp Thr Ser Arg Arg 
            180                 185                 190         


Arg Thr Cys Tyr Ile Ala Pro Glu Arg Phe Val Asp Gly Gly Met Phe 
        195                 200                 205             


Ala Thr Glu Leu Glu Tyr Met Arg Asp Pro Ser Thr Pro Leu Val Asp 
    210                 215                 220                 


Leu Asn Ser Asn Gln Arg Thr Arg Gly Glu Leu Lys Arg Ala Met Asp 
225                 230                 235                 240 


Ile Phe Ser Ala Gly Cys Val Ile Ala Glu Leu Phe Thr Glu Gly Val 
                245                 250                 255     


Pro Leu Phe Asp Leu Ser Gln Leu Leu Ala Tyr Arg Asn Gly His Phe 
            260                 265                 270         


Phe Pro Glu Gln Val Leu Asn Lys Ile Glu Asp His Ser Ile Arg Glu 
        275                 280                 285             


Leu Val Thr Gln Met Ile His Arg Glu Pro Asp Lys Arg Leu Glu Ala 
    290                 295                 300                 


Glu Asp Tyr Leu Lys Gln Gln Arg Gly Asn Ala Phe Pro Glu Ile Phe 
305                 310                 315                 320 


Tyr Thr Phe Leu Gln Pro Tyr Met Ala Gln Phe Ala Lys Glu Thr Phe 
                325                 330                 335     


Leu Ser Ala Asp Glu Arg Ile Leu Val Ile Arg Lys Asp Leu Gly Asn 
            340                 345                 350         


Ile Ile His Asn Leu Cys Gly His Asp Leu Pro Glu Lys Ala Glu Gly 
        355                 360                 365             


Glu Pro Lys Glu Asn Gly Leu Val Ile Leu Val Ser Val Ile Thr Ser 
    370                 375                 380                 


Cys Leu Gln Thr Leu Lys Tyr Cys Asp Ser Lys Leu Ala Ala Leu Glu 
385                 390                 395                 400 


Leu Ile Leu His Leu Ala Pro Arg Leu Ser Val Glu Ile Leu Leu Asp 
                405                 410                 415     


Arg Ile Thr Pro Tyr Leu Leu His Phe Ser Asn Asp Ser Val Pro Arg 
            420                 425                 430         


Val Arg Ala Glu Ala Leu Arg Thr Leu Thr Lys Val Leu Ala Leu Val 
        435                 440                 445             


Lys Glu Val Pro Arg Asn Asp Ile Asn Ile Tyr Pro Glu Tyr Ile Leu 
    450                 455                 460                 


Pro Gly Ile Ala His Leu Ala Gln Asp Asp Ala Thr Ile Val Arg Leu 
465                 470                 475                 480 


Ala Tyr Ala Glu Asn Ile Ala Leu Leu Ala Glu Thr Ala Leu Arg Phe 
                485                 490                 495     


Leu Glu Leu Val Gln Leu Lys Asn Leu Asn Met Glu Asn Asp Pro Asn 
            500                 505                 510         


Asn Glu Glu Ile Asp Glu Val Thr His Pro Asn Gly Asn Tyr Asp Thr 
        515                 520                 525             


Glu Leu Gln Ala Leu His Glu Met Val Gln Gln Lys Val Val Thr Leu 
    530                 535                 540                 


Leu Ser Asp Pro Glu Asn Ile Val Lys Gln Thr Leu Met Glu Asn Gly 
545                 550                 555                 560 


Ile Thr Arg Leu Cys Val Phe Phe Gly Arg Gln Lys Ala Asn Asp Val 
                565                 570                 575     


Leu Leu Ser His Met Ile Thr Phe Leu Asn Asp Lys Asn Asp Trp His 
            580                 585                 590         


Leu Arg Gly Ala Phe Phe Asp Ser Ile Val Gly Val Ala Ala Tyr Val 
        595                 600                 605             


Gly Trp Gln Ser Ser Ser Ile Leu Lys Pro Leu Leu Gln Gln Gly Leu 
    610                 615                 620                 


Ser Asp Ala Glu Glu Phe Val Ile Val Lys Ala Leu Tyr Ala Leu Thr 
625                 630                 635                 640 


Cys Met Cys Gln Leu Gly Leu Leu Gln Lys Pro His Val Tyr Glu Phe 
                645                 650                 655     


Ala Ser Asp Ile Ala Pro Phe Leu Cys His Pro Asn Leu Trp Ile Arg 
            660                 665                 670         


Tyr Gly Ala Val Gly Phe Ile Thr Val Val Ala Arg Gln Ile Ser Thr 
        675                 680                 685             


Ala Asp Val Tyr Cys Lys Leu Met Pro Tyr Leu Asp Pro Tyr Ile Thr 
    690                 695                 700                 


<210>  9813
<211>  381
<212>  DNA
<213>  Homosapiens

<400>  9813
aaaaacccca cacacagttc cttcatcttt gccttacttg ctgaagatta gaagtcccag     60

ggaatccaac cttattttat ctttgaaaat atcctgaagt gccaaataaa ccaacagtct    120

gaagcggggg aagactctag ccccagcaat acctgcgact actaatgaaa aagacttgac    180

ggactgaaac tgcccgagat ttctcacata atgtcatcat tacgtggatg tgcttcagtg    240

ctctgaaata atggcacttt aatctcaagt ccacctgcca ccatctgaaa aggggggaaa    300

aaagccaaag atataaaata ctgaagaaag gtgagggtac tgcttcatta cccatacaat    360

acagttttat ttcagtgcta c                                              381


<210>  9814
<211>  37
<212>  PRT
<213>  Homosapiens

<400>  9814

Lys Ser Gln Gly Ile Gln Pro Tyr Phe Ile Phe Glu Asn Ile Leu Lys 
1               5                   10                  15      


Cys Gln Ile Asn Gln Gln Ser Glu Ala Gly Glu Asp Ser Ser Pro Ser 
            20                  25                  30          


Asn Thr Cys Asp Tyr 
        35          


<210>  9815
<211>  714
<212>  DNA
<213>  Homosapiens

<400>  9815
gtaggaggga agttgtcgag ctacaaacaa atctttaggc atctgaggaa ttgctaagtt     60

tctaatttca tatggttgct gacaaggagg tgcagacaag gaccctcttg ctttcctcac    120

tatggatagt ctgttgcctc catctagatt ctcttatttc aaaaaatatc ctctccatgc    180

aattaggaga tatttatcga cgctgagaaa ccaaagagcc gaagaacaga ttctcttgca    240

gcaagtgttt cacaaagcca aatccccaca tatgtagaag attaacagca ttaatgagat    300

gaagatgctg aaggaggaaa gccgagaagg agtcagaaaa cacaggccag ctaatttaat    360

ctacaagaat ttgggatgac ctgtaccaat gtctcgctct cttgaacaga gatttttttt    420

ttcctgattg agaaatacca ttcaagggct gatctgacaa gtcttgcctg tttaacagtg    480

aatctgctta aaatgaggag agtggtcttt gggcccaggg ggcatgtact gtagctacat    540

tttaattaca gagtagaatc aaattttgtt ttggaagctg ttctaaagtt tcctttcaat    600

ggcttaagaa aatgtttcta gttggaacgg gatcactgga attttttttc tttgctgctc    660

tgtttcttaa tgaatgctaa cctcaaagtt gcactgttaa ataaatattt gaat          714


<210>  9816
<211>  51
<212>  PRT
<213>  Homosapiens

<400>  9816

Met Asp Ser Leu Leu Pro Pro Ser Arg Phe Ser Tyr Phe Lys Lys Tyr 
1               5                   10                  15      


Pro Leu His Ala Ile Arg Arg Tyr Leu Ser Thr Leu Arg Asn Gln Arg 
            20                  25                  30          


Ala Glu Glu Gln Ile Leu Leu Gln Gln Val Phe His Lys Ala Lys Ser 
        35                  40                  45              


Pro His Met 
    50      


<210>  9817
<211>  4967
<212>  DNA
<213>  Homosapiens

<400>  9817
caaagctggg ttcgcggctg gcccaggagt gcggggcgcg actgggcggc cggcggcggg     60

gaggggcgga gcgcaggagt cggaggcggg agcagaccag cacggcctcg cggagccggc    120

ccggcggacc gtgacgggtc ccctcacctc ctcttctctc ccctccccgc ccgccctctc    180

tccctccctt cctccctccc gctcgcttct tctcacgccg ggagcaggct cccgcctcgc    240

accgctgccc cgcgagcagc tcctcttctc ccgaggcgcg cggggcgccc ccgcgagccc    300

cgcggctgag accccgcagc ctggaggagg gctgtccggg gctttggtgt ggccgtggct    360

gacactaaag actttgtagc catcaacccg agtgcagttt cgatggaaaa tgaaggttgc    420

acgttttcaa aaaataccta atggtgaaaa tgagacaatg attcctgtat tgacatcaaa    480

aaaagcaagt gaattaccag tcagtgaagt tgcaagcatt ctccaagctg atcttcagaa    540

tggtctaaac aaatgtgaag ttagtcatag gcgagccttt catggctgga atgagtttga    600

tattagtgaa gatgagccac tgtggaagaa gtatatttct cagtttaaaa atccccttat    660

tatgctgctt ctggcttctg cagtcatcag tgttttaatg catcagtttg atgatgccgt    720

cagtatcact gtggcaatac ttatcgttgt tacagttgcc tttgttcagg aatatcgttc    780

agaaaaatct cttgaagaat tgagtaaact tgtgccacca gaatgccatt gtgtgcgtga    840

aggaaaattg gagcatacac ttgcccgaga cttggttcca ggtgatacag tttgcctttc    900

tgttggggat agagttcctg ctgacttacg cttgtttgag gctgtggatc tttccattga    960

tgagtccagc ttgacaggtg agacaacgcc ttgttctaag gtgacagctc ctcagccagc   1020

tgcaactaat ggagatcttg catcgagaag taacattgcc tttatgggaa cactggtcag   1080

atgtggcaaa gcaaagggtg ttgtcattgg aacaggagaa aattctgaat ttggggaggt   1140

ttttaaaatg atgcaagcag aagaggcacc aaaaacccct ctgcagaaga gcatggacct   1200

cttaggaaaa caactttcct tttactcctt tggtataata ggaatcatca tgttggttgg   1260

ctggttactg ggaaaagata tcctggaaat gtttactatt agtgtaagtt tggctgtagc   1320

agcaattcct gaaggtctcc ccattgtggt cacagtgacg ctagctcttg gtgttatgag   1380

aatggtgaag aaaagggcca ttgtgaaaaa gctgcctatt gttgaaactc tgggctgctg   1440

taatgtgatt tgttcagata aaactggaac actgacgaag aatgaaatga ctgttactca   1500

catatttact tcagatggtc tgcatgctga ggttactgga gttggctata atcaatttgg   1560

ggaagtgatt gttgatggtg atgttgttca tggattctat aacccagctg ttagcagaat   1620

tgttgaggcg ggctgtgtgt gcaatgatgc tgtaattaga aacaatactc taatggggaa   1680

gccaacagaa ggggccttaa ttgctcttgc aatgaagatg ggtcttgatg gacttcaaca   1740

agactacatc agaaaagctg aatacccttt tagctctgag caaaagtgga tggctgttaa   1800

gtgtgtacac cgaacacagc aggacagacc agagatttgt tttatgaaag gtgcttacga   1860

acaagtaatt aagtactgta ctacatacca gagcaaaggg cagaccttga cacttactca   1920

gcagcagaga gatgtgtacc aacaagagaa ggcacgcatg ggctcagcgg gactcagagt   1980

tcttgctttg gcttctggtc ctgaactggg acagctgaca tttcttggct tggtgggaat   2040

cattgatcca cctagaactg gtgtgaaaga agctgttaca acactcattg cctcaggagt   2100

atcaataaaa atgattactg gagattcaca ggagactgca gttgcaatcg ccagtcgtct   2160

gggattgtat tccaaaactt cccagtcagt ctcaggagaa gaaatagatg caatggatgt   2220

tcagcagctt tcacaaatag taccaaaggt tgcagtattt tacagagcta gcccaaggca   2280

caagatgaaa attattaagt cgctacagaa gaacggttca gttgtagcca tgacaggaga   2340

tggagtaaat gatgcagttg ctctgaaggc tgcagacatt ggagttgcga tgggccagac   2400

tggtacagat gtttgcaaag aggcagcaga catgatccta gtggatgatg attttcaaac   2460

cataatgtct gcaatcgaag agggtaaagg gatttataat aacattaaaa atttcgttag   2520

attccagctg agcacgagta tagcagcatt aactttaatc tcattggcta cattaatgaa   2580

ctttcctaat cctctcaatg ccatgcagat tttgtggatc aatattatta tggatggacc   2640

cccagctcag agccttggag tagaaccagt ggataaagat gtcattcgta aacctcctcg   2700

caactggaaa gacagcattt tgactaaaaa cttgatactt aaaatacttg tttcatcaat   2760

aatcattgtt tgtgggactt tgtttgtctt ctggcgtgag ctacgagaca atgtgattac   2820

acctcgagac acaacaatga ccttcacatg ctttgtgttt tttgacatgt tcaatgcact   2880

aagttccaga tcccagacca agtctgtgtt tgagattgga ctctgcagta atagaatgtt   2940

ttgctatgca gttcttggat ccatcatggg acaattacta gttatttact ttcctccgct   3000

tcagaaggtt tttcagactg agagcctaag catactggat ctgttgtttc ttttgggtct   3060

cacctcatca gtgtgcatag tggcagaaat tataaagaag gttgaaagga gcagggaaaa   3120

gatccagaag catgttagtt cgacatcatc atcttttctt gaagtatgat gcatattgca   3180

ttattttatt tgcaaactag gaattgcagt ctgaggatca tttagaaggg caagttcaag   3240

aggatatgaa gatttgagaa ctttttaact attcattgac taaaaatgaa cattaatgtt   3300

aaagacttaa gactttaacc tgctggcagt cccaaatgaa attatgcaac tttgatatca   3360

tattccttga tttaaattgg cttttgtgat tgagtgaaac tttataaagc atatggtcag   3420

ttatttaatt aaaaaggcaa aacctgaacc accttctgca cttaaagaag tctaacagta   3480

caaatacact atctatctta gatagatata ttttttttta tttttaaata ttgtactatt   3540

tatggtggtg gggctttctt actaatacac aaataaattt aatcatttca aaggcattct   3600

atttggttta gaagttgatt cccaggagtg ccatatttca gctactgtat ttcctttttc   3660

ttgtaatgta agcagctcag ataccatgtg ctatcatttt tgtatcaagt tttttgcaca   3720

ggatgtgacc actgtcagat cactgttctt ttctttcttt ttgtgattga aaagcctata   3780

ctacaatttg aagtaaattt ttgtttttct tagtaagtgt aaatggttgc tttattttta   3840

ttttaaaaag gtatgtcttt ggtttggcag aattcatgca gggctatcaa gtggtgttct   3900

agggtaacag tgtccataat taacgcttag tcatagagtc aaaaacattt aagactgatt   3960

gggttgaagt ttataataaa ttatattaac atgtcttcct ttttgaggta aagatatata   4020

ctttgtcaaa tatcattttg tcatcctcta aatataaatc caaatacctc agctaagtaa   4080

ttctatttta ttatttttac tgttatgtat gtttttaatc atatttctta ggaagtatag   4140

gctactggac ttagaataaa aagtccccaa acccaaacaa atggtttatg aaccagagta   4200

tatgtggaag attctttgct ggtcttgctc tgtgtgcatc tgaagcttct ttggcctaga   4260

ttttagcaca aacctgagta tatctcttct actttcatca tgtgttctgt accttctttt   4320

tgtttcattg ggcatgctag ggaaataggt ggattttgtg tgtaatgcca tcagttttta   4380

tgaaagcttg atgaggtata ggtcatttgt tttgagtatg tgggccagaa atttaaaatt   4440

agaaatttgt ttttctgttg agtatataaa caaaaattgg tcccaattct aacaggttta   4500

atccttcttg aagccaataa gttttatctt ttataatctg tcaggatgaa ccactcctta   4560

gcttttatcc aatattaaac tgcaagtgtt agcactgaaa tattgtcatt gatagggaaa   4620

atatctattc tttgagtcat tgttactgag gcagttgagt gtaaggagct ggctgcagtt   4680

tattctactt aaccctttaa ggctgaattg tcaaatgtac attgttccat gtcgttagat   4740

ggaacatgga agccattgtc taatcaactc tatcattagt gacttgatgt ctcatacctt   4800

aattttgtaa tgatttttat tctctgttac aaagacttga aatacgtatt aaatgcacgt   4860

taatgttttg ctttgcattt taggttcaga ttatgacttg attgaaataa atgtgcctat   4920

acattcattt gctttgtact ataaaaataa aaatgatttc ttaagtt                 4967


<210>  9818
<211>  919
<212>  PRT
<213>  Homosapiens

<400>  9818

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val 
        915                 


<210>  9819
<211>  5058
<212>  DNA
<213>  Homosapiens

<400>  9819
caaagctggg ttcgcggctg gcccaggagt gcggggcgcg actgggcggc cggcggcggg     60

gaggggcgga gcgcaggagt cggaggcggg agcagaccag cacggcctcg cggagccggc    120

ccggcggacc gtgacgggtc ccctcacctc ctcttctctc ccctccccgc ccgccctctc    180

tccctccctt cctccctccc gctcgcttct tctcacgccg ggagcaggct cccgcctcgc    240

accgctgccc cgcgagcagc tcctcttctc ccgaggcgcg cggggcgccc ccgcgagccc    300

cgcggctgag accccgcagc ctggaggagg gctgtccggg gctttggtgt ggccgtggct    360

gacactaaag actttgtagc catcaacccg agtgcagttt cgatggaaaa tgaaggttgc    420

acgttttcaa aaaataccta atggtgaaaa tgagacaatg attcctgtat tgacatcaaa    480

aaaagcaagt gaattaccag tcagtgaagt tgcaagcatt ctccaagctg atcttcagaa    540

tggtctaaac aaatgtgaag ttagtcatag gcgagccttt catggctgga atgagtttga    600

tattagtgaa gatgagccac tgtggaagaa gtatatttct cagtttaaaa atccccttat    660

tatgctgctt ctggcttctg cagtcatcag tgttttaatg catcagtttg atgatgccgt    720

cagtatcact gtggcaatac ttatcgttgt tacagttgcc tttgttcagg aatatcgttc    780

agaaaaatct cttgaagaat tgagtaaact tgtgccacca gaatgccatt gtgtgcgtga    840

aggaaaattg gagcatacac ttgcccgaga cttggttcca ggtgatacag tttgcctttc    900

tgttggggat agagttcctg ctgacttacg cttgtttgag gctgtggatc tttccattga    960

tgagtccagc ttgacaggtg agacaacgcc ttgttctaag gtgacagctc ctcagccagc   1020

tgcaactaat ggagatcttg catcgagaag taacattgcc tttatgggaa cactggtcag   1080

atgtggcaaa gcaaagggtg ttgtcattgg aacaggagaa aattctgaat ttggggaggt   1140

ttttaaaatg atgcaagcag aagaggcacc aaaaacccct ctgcagaaga gcatggacct   1200

cttaggaaaa caactttcct tttactcctt tggtataata ggaatcatca tgttggttgg   1260

ctggttactg ggaaaagata tcctggaaat gtttactatt agtgtaagtt tggctgtagc   1320

agcaattcct gaaggtctcc ccattgtggt cacagtgacg ctagctcttg gtgttatgag   1380

aatggtgaag aaaagggcca ttgtgaaaaa gctgcctatt gttgaaactc tgggctgctg   1440

taatgtgatt tgttcagata aaactggaac actgacgaag aatgaaatga ctgttactca   1500

catatttact tcagatggtc tgcatgctga ggttactgga gttggctata atcaatttgg   1560

ggaagtgatt gttgatggtg atgttgttca tggattctat aacccagctg ttagcagaat   1620

tgttgaggcg ggctgtgtgt gcaatgatgc tgtaattaga aacaatactc taatggggaa   1680

gccaacagaa ggggccttaa ttgctcttgc aatgaagatg ggtcttgatg gacttcaaca   1740

agactacatc agaaaagctg aatacccttt tagctctgag caaaagtgga tggctgttaa   1800

gtgtgtacac cgaacacagc aggacagacc agagatttgt tttatgaaag gtgcttacga   1860

acaagtaatt aagtactgta ctacatacca gagcaaaggg cagaccttga cacttactca   1920

gcagcagaga gatgtgtacc aacaagagaa ggcacgcatg ggctcagcgg gactcagagt   1980

tcttgctttg gcttctggtc ctgaactggg acagctgaca tttcttggct tggtgggaat   2040

cattgatcca cctagaactg gtgtgaaaga agctgttaca acactcattg cctcaggagt   2100

atcaataaaa atgattactg gagattcaca ggagactgca gttgcaatcg ccagtcgtct   2160

gggattgtat tccaaaactt cccagtcagt ctcaggagaa gaaatagatg caatggatgt   2220

tcagcagctt tcacaaatag taccaaaggt tgcagtattt tacagagcta gcccaaggca   2280

caagatgaaa attattaagt cgctacagaa gaacggttca gttgtagcca tgacaggaga   2340

tggagtaaat gatgcagttg ctctgaaggc tgcagacatt ggagttgcga tgggccagac   2400

tggtacagat gtttgcaaag aggcagcaga catgatccta gtggatgatg attttcaaac   2460

cataatgtct gcaatcgaag agggtaaagg gatttataat aacattaaaa atttcgttag   2520

attccagctg agcacgagta tagcagcatt aactttaatc tcattggcta cattaatgaa   2580

ctttcctaat cctctcaatg ccatgcagat tttgtggatc aatattatta tggatggacc   2640

cccagctcag agccttggag tagaaccagt ggataaagat gtcattcgta aacctcctcg   2700

caactggaaa gacagcattt tgactaaaaa cttgatactt aaaatacttg tttcatcaat   2760

aatcattgtt tgtgggactt tgtttgtctt ctggcgtgag ctacgagaca atgtgattac   2820

acctcgagac acaacaatga ccttcacatg ctttgtgttt tttgacatgt tcaatgcact   2880

aagttccaga tcccagacca agtctgtgtt tgagattgga ctctgcagta atagaatgtt   2940

ttgctatgca gttcttggat ccatcatggg acaattacta gttatttact ttcctccgct   3000

tcagaaggtt tttcagactg agagcctaag catactggat ctgttgtttc ttttgggtct   3060

cacctcatca gtgtgcatag tggcagaaat tataaagaag gttgaaagga gcagggaaaa   3120

gatccagaag catgttagtt cgacatcatc atcttttctt gaagtatgat gcatattgca   3180

ttattttatt tgcaaactag gaattgcagt ctgaggatca tttagaaggg caagttcaag   3240

aggatatgaa gatttgagaa ctttttaact attcattgac taaaaatgaa cattaatgtt   3300

aaagacttaa gactttaacc tgctggcagt cccaaatgaa attatgcaac tttgatatca   3360

tattccttga tttaaattgg cttttgtgat tgagtgaaac tttataaagc atatggtcag   3420

ttatttaatt aaaaaggcaa aacctgaacc accttctgca cttaaagaag tctaacagta   3480

caaatacact atctatctta gatagatata ttttttttta tttttaaata ttgtactatt   3540

tatggtggtg gggctttctt actaatacac aaataaattt aatcatttca aaggcattct   3600

atttggttta gaagttgatt cccaggagtg ccatatttca gctactgtat ttcctttttc   3660

ttgtaatgta agcagctcag ataccatgtg ctatcatttt tgtatcaagt tttttgcaca   3720

ggatgtgacc actgtcagat cactgttctt ttctttcttt ttgtgattga aaagcctata   3780

ctacaatttg aagtaaattt ttgtttttct tagtaagtgt aaatggttgc tttattttta   3840

ttttaaaaag gtatgtcttt ggtttggcag aattcatgca gggctatcaa gtggtgttct   3900

agggtaacag tgtccataat taacgcttag tcatagagtc aaaaacattt aagactgatt   3960

gggttgaagt ttataataaa ttatattaac atgtcttcct ttttgaggta aagatatata   4020

ctttgtcaaa tatcattttg tcatcctcta aatataaatc caaatacctc agctaagtaa   4080

ttctatttta ttatttttac tgttatgtat gtttttaatc atatttctta ggaagtatag   4140

gctactggac ttagaataaa aagtccccaa acccaaacaa atggtttatg aaccagagta   4200

tatgtggaag attctttgct ggtcttgctc tgtgtgcatc tgaagcttct ttggcctaga   4260

ttttagcaca aacctgagta tatctcttct actttcatca tgtgttctgt accttctttt   4320

tgtttcattg ggcatgctag ggaaataggt ggattttgtg tgtaatgcca tcagttttta   4380

tgaaagcttg atgaggtata ggtcatttgt tttgagtatg tgggccagaa atttaaaatt   4440

agaaatttgt ttttctgttg agtatataaa caaaaattgg tcccaattct aacaggttta   4500

atccttcttg aagccaataa gttttatctt ttataatctg tcaggatgaa ccactcctta   4560

gcttttatcc aatattaaac tgcaagtgtt agcactgaaa tattgtcatt gatagggaaa   4620

atatctattc tttgagtcat tgttactgag gcagttgagt gtaaggagct ggctgcagtt   4680

tattctactt aaccctttaa ggctgaattg tcaaatgtac attgttccat gtcgttagat   4740

ggaacatgga agccattgtc taatcaactc tatcattagt gacttgatgt ctcatacctt   4800

aattttgtaa tgatttttat tctctgttac aaagacttga aatacgtatt aaatgcacgt   4860

taatgttttg ctttgcattt taggttcaga ttatgacttg attgaaataa atgtgcctat   4920

acattcattt gctttgtact ataaaaataa aaatgatttc ttaagttaat gacatcccag   4980

tggggactat tagcattaaa attatccata tggatgctga agatacagaa attaaaatta   5040

tccatatgga tgctggag                                                 5058


<210>  9820
<211>  919
<212>  PRT
<213>  Homosapiens

<400>  9820

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val 
        915                 


<210>  9821
<211>  3652
<212>  DNA
<213>  Homosapiens

<400>  9821
cgcgactggg cggccggcgg cggggagggg cggagcgcag gagtcggagg cgggagcaga     60

ccagcacggc ctcgcggagc cggcccggcg gaccgtgacg ggtcccctca cctcctcttc    120

tctcccctcc ccgcccgccc tctctccctc ccttcctccc tcccgctcgc ttcttctcac    180

gccgggagca ggctcccgcc tcgcaccgct gccccgcgag cagctcctct tctcccgagg    240

cgcgcggggc gcccccgcga gccccgcggc tgagaccccg cagcctggag gagggctgtc    300

cggggctttg gatgctgctg ctaggggtgg tgggagcagc cgtgggacgc gtggccggga    360

gcgggggtga cagcctggga ttccgggggc ttctcttcct tgtcctcctc ctctcctctc    420

tattcccagt gtggccgtgg ctgacactaa agactttgta gccatcaacc cgagtgcagt    480

ttcgatggaa aatgaaggtt gcacgttttc aaaaaatacc taatggtgaa aatgagacaa    540

tgattcctgt attgacatca aaaaaagcaa gtgaattacc agtcagtgaa gttgcaagca    600

ttctccaagc tgatcttcag aatggtctaa acaaatgtga agttagtcat aggcgagcct    660

ttcatggctg gaatgagttt gatattagtg aagatgagcc actgtggaag aagtatattt    720

ctcagtttaa aaatcccctt attatgctgc ttctggcttc tgcagtcatc agtgttttaa    780

tgcatcagtt tgatgatgcc gtcagtatca ctgtggcaat acttatcgtt gttacagttg    840

cctttgttca ggaatatcgt tcagaaaaat ctcttgaaga attgagtaaa cttgtgccac    900

cagaatgcca ttgtgtgcgt gaaggaaaat tggagcatac acttgcccga gacttggttc    960

caggtgatac agtttgcctt tctgttgggg atagagttcc tgctgactta cgcttgtttg   1020

aggctgtgga tctttccatt gatgagtcca gcttgacagg tgagacaacg ccttgttcta   1080

aggtgacagc tcctcagcca gctgcaacta atggagatct tgcatcgaga agtaacattg   1140

cctttatggg aacactggtc agatgtggca aagcaaaggg tgttgtcatt ggaacaggag   1200

aaaattctga atttggggag gtttttaaaa tgatgcaagc agaagaggca ccaaaaaccc   1260

ctctgcagaa gagcatggac ctcttaggaa aacaactttc cttttactcc tttggtataa   1320

taggaatcat catgttggtt ggctggttac tgggaaaaga tatcctggaa atgtttacta   1380

ttagtgtaag tttggctgta gcagcaattc ctgaaggtct ccccattgtg gtcacagtga   1440

cgctagctct tggtgttatg agaatggtga agaaaagggc cattgtgaaa aagctgccta   1500

ttgttgaaac tctgggctgc tgtaatgtga tttgttcaga taaaactgga acactgacga   1560

agaatgaaat gactgttact cacatattta cttcagatgg tctgcatgct gaggttactg   1620

gagttggcta taatcaattt ggggaagtga ttgttgatgg tgatgttgtt catggattct   1680

ataacccagc tgttagcaga attgttgagg cgggctgtgt gtgcaatgat gctgtaatta   1740

gaaacaatac tctaatgggg aagccaacag aaggggcctt aattgctctt gcaatgaaga   1800

tgggtcttga tggacttcaa caagactaca tcagaaaagc tgaataccct tttagctctg   1860

agcaaaagtg gatggctgtt aagtgtgtac accgaacaca gcaggacaga ccagagattt   1920

gttttatgaa aggtgcttac gaacaagtaa ttaagtactg tactacatac cagagcaaag   1980

ggcagacctt gacacttact cagcagcaga gagatgtgta ccaacaagag aaggcacgca   2040

tgggctcagc gggactcaga gttcttgctt tggcttctgg tcctgaactg ggacagctga   2100

catttcttgg cttggtggga atcattgatc cacctagaac tggtgtgaaa gaagctgtta   2160

caacactcat tgcctcagga gtatcaataa aaatgattac tggagattca caggagactg   2220

cagttgcaat cgccagtcgt ctgggattgt attccaaaac ttcccagtca gtctcaggag   2280

aagaaataga tgcaatggat gttcagcagc tttcacaaat agtaccaaag gttgcagtat   2340

tttacagagc tagcccaagg cacaagatga aaattattaa gtcgctacag aagaacggtt   2400

cagttgtagc catgacagga gatggagtaa atgatgcagt tgctctgaag gctgcagaca   2460

ttggagttgc gatgggccag actggtacag atgtttgcaa agaggcagca gacatgatcc   2520

tagtggatga tgattttcaa accataatgt ctgcaatcga agagggtaaa gggatttata   2580

ataacattaa aaatttcgtt agattccagc tgagcacgag tatagcagca ttaactttaa   2640

tctcattggc tacattaatg aactttccta atcctctcaa tgccatgcag attttgtgga   2700

tcaatattat tatggatgga cccccagctc agagccttgg agtagaacca gtggataaag   2760

atgtcattcg taaacctcct cgcaactgga aagacagcat tttgactaaa aacttgatac   2820

ttaaaatact tgtttcatca ataatcattg tttgtgggac tttgtttgtc ttctggcgtg   2880

agctacgaga caatgtgatt acacctcgag acacaacaat gaccttcaca tgctttgtgt   2940

tttttgacat gttcaatgca ctaagttcca gatcccagac caagtctgtg tttgagattg   3000

gactctgcag taatagaatg ttttgctatg cagttcttgg atccatcatg ggacaattac   3060

tagttattta ctttcctccg cttcagaagg tttttcagac tgagagccta agcatactgg   3120

gtctggctct gggagaggag tggacagcag ctggttgaga tacatcccca tctggagaca   3180

ggactgccac tgacagaaga tgtgagctgt gtctaagtcc agtcttgtgc ccagccgtgt   3240

ctgcgccttc actctttgga actctgcata caacatctta gcaccatctt cctgcagctc   3300

ttccttacct aaataaagaa acagcccaag ggcagtattt ctaaaagcac tgtaacagct   3360

tttcattttc tccacatata ctacaaattc tataaagaaa gaaattaatt taaaaaaact   3420

aagatgtttt tctcttctgg cttcataaat gccttgctgt ataaattgaa atattgatac   3480

tgaactgtct ttttaatgat gacctaactt tattcaaccc atcggaattt actttttccc   3540

tgaaataaga tcttttccac tggtctacta cctgaccata aacatgtctg catttgaatt   3600

ctctaaaccc taaatctgtg tctatgaaaa atacaaatga ctattaaata tt           3652


<210>  9822
<211>  888
<212>  PRT
<213>  Homosapiens

<400>  9822

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Gly Leu Ala Leu 
865                 870                 875                 880 


Gly Glu Glu Trp Thr Ala Ala Gly 
                885             


<210>  9823
<211>  4712
<212>  DNA
<213>  Homosapiens

<400>  9823
cttcctccct cccgctcgct tcttctcacg ccgggagcag gctcccgcct cgcaccgctg     60

ccccgcgagc agctcctctt ctcccgaggc gcgcggggcg cccccgcgag ccccgcggct    120

gagaccccgc agcctggagg agggctgtcc ggggctttgg gttgcacgtt ttcaaaaaat    180

acctaatggt gaaaatgaga caatgattcc tgtattgaca tcaaaaaaag caagtgaatt    240

accagtcagt gaagttgcaa gcattctcca agctgatctt cagaatggtc taaacaaatg    300

tgaagttagt cataggcgag cctttcatgg ctggaatgag tttgatatta gtgaagatga    360

gccactgtgg aagaagtata tttctcagtt taaaaatccc cttattatgc tgcttctggc    420

ttctgcagtc atcagtgttt taatgcatca gtttgatgat gccgtcagta tcactgtggc    480

aatacttatc gttgttacag ttgcctttgt tcaggaatat cgttcagaaa aatctcttga    540

agaattgagt aaacttgtgc caccagaatg ccattgtgtg cgtgaaggaa aattggagca    600

tacacttgcc cgagacttgg ttccaggtga tacagtttgc ctttctgttg gggatagagt    660

tcctgctgac ttacgcttgt ttgaggctgt ggatctttcc attgatgagt ccagcttgac    720

aggtgagaca acgccttgtt ctaaggtgac agctcctcag ccagctgcaa ctaatggaga    780

tcttgcatcg agaagtaaca ttgcctttat gggaacactg gtcagatgtg gcaaagcaaa    840

gggtgttgtc attggaacag gagaaaattc tgaatttggg gaggttttta aaatgatgca    900

agcagaagag gcaccaaaaa cccctctgca gaagagcatg gacctcttag gaaaacaact    960

ttccttttac tcctttggta taataggaat catcatgttg gttggctggt tactgggaaa   1020

agatatcctg gaaatgttta ctattagtgt aagtttggct gtagcagcaa ttcctgaagg   1080

tctccccatt gtggtcacag tgacgctagc tcttggtgtt atgagaatgg tgaagaaaag   1140

ggccattgtg aaaaagctgc ctattgttga aactctgggc tgctgtaatg tgatttgttc   1200

agataaaact ggaacactga cgaagaatga aatgactgtt actcacatat ttacttcaga   1260

tggtctgcat gctgaggtta ctggagttgg ctataatcaa tttggggaag tgattgttga   1320

tggtgatgtt gttcatggat tctataaccc agctgttagc agaattgttg aggcgggctg   1380

tgtgtgcaat gatgctgtaa ttagaaacaa tactctaatg gggaagccaa cagaaggggc   1440

cttaattgct cttgcaatga agatgggtct tgatggactt caacaagact acatcagaaa   1500

agctgaatac ccttttagct ctgagcaaaa gtggatggct gttaagtgtg tacaccgaac   1560

acagcaggac agaccagaga tttgttttat gaaaggtgct tacgaacaag taattaagta   1620

ctgtactaca taccagagca aagggcagac cttgacactt actcagcagc agagagatgt   1680

gtaccaacaa gagaaggcac gcatgggctc agcgggactc agagttcttg ctttggcttc   1740

tggtcctgaa ctgggacagc tgacatttct tggcttggtg ggaatcattg atccacctag   1800

aactggtgtg aaagaagctg ttacaacact cattgcctca ggagtatcaa taaaaatgat   1860

tactggagat tcacaggaga ctgcagttgc aatcgccagt cgtctgggat tgtattccaa   1920

aacttcccag tcagtctcag gagaagaaat agatgcaatg gatgttcagc agctttcaca   1980

aatagtacca aaggttgcag tattttacag agctagccca aggcacaaga tgaaaattat   2040

taagtcgcta cagaagaacg gttcagttgt agccatgaca ggagatggag taaatgatgc   2100

agttgctctg aaggctgcag acattggagt tgcgatgggc cagactggta cagatgtttg   2160

caaagaggca gcagacatga tcctagtgga tgatgatttt caaaccataa tgtctgcaat   2220

cgaagagggt aaagggattt ataataacat taaaaatttc gttagattcc agctgagcac   2280

gagtatagca gcattaactt taatctcatt ggctacatta atgaactttc ctaatcctct   2340

caatgccatg cagattttgt ggatcaatat tattatggat ggacccccag ctcagagcct   2400

tggagtagaa ccagtggata aagatgtcat tcgtaaacct cctcgcaact ggaaagacag   2460

cattttgact aaaaacttga tacttaaaat acttgtttca tcaataatca ttgtttgtgg   2520

gactttgttt gtcttctggc gtgagctacg agacaatgtg attacacctc gagacacaac   2580

aatgaccttc acatgctttg tgttttttga catgttcaat gcactaagtt ccagatccca   2640

gaccaagtct gtgtttgaga ttggactctg cagtaataga atgttttgct atgcagttct   2700

tggatccatc atgggacaat tactagttat ttactttcct ccgcttcaga aggtttttca   2760

gactgagagc ctaagcatac tggatctgtt gtttcttttg ggtctcacct catcagtgtg   2820

catagtggca gaaattataa agaaggttga aaggagcagg gaaaagatcc agaagcatgt   2880

tagttcgaca tcatcatctt ttcttgaagt atgatgcata ttgcattatt ttatttgcaa   2940

actaggaatt gcagtctgag gatcatttag aagggcaagt tcaagaggat atgaagattt   3000

gagaactttt taactattca ttgactaaaa atgaacatta atgttaaaga cttaagactt   3060

taacctgctg gcagtcccaa atgaaattat gcaactttga tatcatattc cttgatttaa   3120

attggctttt gtgattgagt gaaactttat aaagcatatg gtcagttatt taattaaaaa   3180

ggcaaaacct gaaccacctt ctgcacttaa agaagtctaa cagtacaaat acactatcta   3240

tcttagatag atatattttt ttttattttt aaatattgta ctatttatgg tggtggggct   3300

ttcttactaa tacacaaata aatttaatca tttcaaaggc attctatttg gtttagaagt   3360

tgattcccag gagtgccata tttcagctac tgtatttcct ttttcttgta atgtaagcag   3420

ctcagatacc atgtgctatc atttttgtat caagtttttt gcacaggatg tgaccactgt   3480

cagatcactg ttcttttctt tctttttgtg attgaaaagc ctatactaca atttgaagta   3540

aatttttgtt tttcttagta agtgtaaatg gttgctttat ttttatttta aaaaggtatg   3600

tctttggttt ggcagaattc atgcagggct atcaagtggt gttctagggt aacagtgtcc   3660

ataattaacg cttagtcata gagtcaaaaa catttaagac tgattgggtt gaagtttata   3720

ataaattata ttaacatgtc ttcctttttg aggtaaagat atatactttg tcaaatatca   3780

ttttgtcatc ctctaaatat aaatccaaat acctcagcta agtaattcta ttttattatt   3840

tttactgtta tgtatgtttt taatcatatt tcttaggaag tataggctac tggacttaga   3900

ataaaaagtc cccaaaccca aacaaatggt ttatgaacca gagtatatgt ggaagattct   3960

ttgctggtct tgctctgtgt gcatctgaag cttctttggc ctagatttta gcacaaacct   4020

gagtatatct cttctacttt catcatgtgt tctgtacctt ctttttgttt cattgggcat   4080

gctagggaaa taggtggatt ttgtgtgtaa tgccatcagt ttttatgaaa gcttgatgag   4140

gtataggtca tttgttttga gtatgtgggc cagaaattta aaattagaaa tttgtttttc   4200

tgttgagtat ataaacaaaa attggtccca attctaacag gtttaatcct tcttgaagcc   4260

aataagtttt atcttttata atctgtcagg atgaaccact ccttagcttt tatccaatat   4320

taaactgcaa gtgttagcac tgaaatattg tcattgatag ggaaaatatc tattctttga   4380

gtcattgtta ctgaggcagt tgagtgtaag gagctggctg cagtttattc tacttaaccc   4440

tttaaggctg aattgtcaaa tgtacattgt tccatgtcgt tagatggaac atggaagcca   4500

ttgtctaatc aactctatca ttagtgactt gatgtctcat accttaattt tgtaatgatt   4560

tttattctct gttacaaaga cttgaaatac gtattaaatg cacgttaatg ttttgctttg   4620

cattttaggt tcagattatg acttgattga aataaatgtg cctatacatt catttgcttt   4680

gtactataaa aataaaaatg atttcttaag tt                                 4712


<210>  9824
<211>  903
<212>  PRT
<213>  Homosapiens

<400>  9824

Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
1               5                   10                  15      


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
            20                  25                  30          


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
        35                  40                  45              


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
    50                  55                  60                  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
65                  70                  75                  80  


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
                85                  90                  95      


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
            100                 105                 110         


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
        115                 120                 125             


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
    130                 135                 140                 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
145                 150                 155                 160 


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
                165                 170                 175     


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
            180                 185                 190         


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
        195                 200                 205             


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
    210                 215                 220                 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
225                 230                 235                 240 


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
                245                 250                 255     


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
            260                 265                 270         


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
        275                 280                 285             


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
    290                 295                 300                 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
305                 310                 315                 320 


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
                325                 330                 335     


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
            340                 345                 350         


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
        355                 360                 365             


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
    370                 375                 380                 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
385                 390                 395                 400 


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
                405                 410                 415     


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
            420                 425                 430         


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
        435                 440                 445             


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
    450                 455                 460                 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
465                 470                 475                 480 


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
                485                 490                 495     


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
            500                 505                 510         


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
        515                 520                 525             


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
    530                 535                 540                 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
545                 550                 555                 560 


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
                565                 570                 575     


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
            580                 585                 590         


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
        595                 600                 605             


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
    610                 615                 620                 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
625                 630                 635                 640 


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
                645                 650                 655     


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
            660                 665                 670         


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
        675                 680                 685             


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
    690                 695                 700                 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
705                 710                 715                 720 


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
                725                 730                 735     


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
            740                 745                 750         


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
        755                 760                 765             


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
    770                 775                 780                 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
785                 790                 795                 800 


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
                805                 810                 815     


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
            820                 825                 830         


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
        835                 840                 845             


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
    850                 855                 860                 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
865                 870                 875                 880 


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
                885                 890                 895     


Ser Ser Ser Phe Leu Glu Val 
            900             


<210>  9825
<211>  3469
<212>  DNA
<213>  Homosapiens

<400>  9825
cttcctccct cccgctcgct tcttctcacg ccgggagcag gctcccgcct cgcaccgctg     60

ccccgcgagc agctcctctt ctcccgaggc gcgcggggcg cccccgcgag ccccgcggct    120

gagaccccgc agcctggagg agggctgtcc ggggctttgg gttgcacgtt ttcaaaaaat    180

acctaatggt gaaaatgaga caatgattcc tgtattgaca tcaaaaaaag caagtgaatt    240

accagtcagt gaagttgcaa gcattctcca agctgatctt cagaatggtc taaacaaatg    300

tgaagttagt cataggcgag cctttcatgg ctggaatgag tttgatatta gtgaagatga    360

gccactgtgg aagaagtata tttctcagtt taaaaatccc cttattatgc tgcttctggc    420

ttctgcagtc atcagtgttt taatgcatca gtttgatgat gccgtcagta tcactgtggc    480

aatacttatc gttgttacag ttgcctttgt tcaggaatat cgttcagaaa aatctcttga    540

agaattgagt aaacttgtgc caccagaatg ccattgtgtg cgtgaaggaa aattggagca    600

tacacttgcc cgagacttgg ttccaggtga tacagtttgc ctttctgttg gggatagagt    660

tcctgctgac ttacgcttgt ttgaggctgt ggatctttcc attgatgagt ccagcttgac    720

aggtgagaca acgccttgtt ctaaggtgac agctcctcag ccagctgcaa ctaatggaga    780

tcttgcatcg agaagtaaca ttgcctttat gggaacactg gtcagatgtg gcaaagcaaa    840

gggtgttgtc attggaacag gagaaaattc tgaatttggg gaggttttta aaatgatgca    900

agcagaagag gcaccaaaaa cccctctgca gaagagcatg gacctcttag gaaaacaact    960

ttccttttac tcctttggta taataggaat catcatgttg gttggctggt tactgggaaa   1020

agatatcctg gaaatgttta ctattagtgt aagtttggct gtagcagcaa ttcctgaagg   1080

tctccccatt gtggtcacag tgacgctagc tcttggtgtt atgagaatgg tgaagaaaag   1140

ggccattgtg aaaaagctgc ctattgttga aactctgggc tgctgtaatg tgatttgttc   1200

agataaaact ggaacactga cgaagaatga aatgactgtt actcacatat ttacttcaga   1260

tggtctgcat gctgaggtta ctggagttgg ctataatcaa tttggggaag tgattgttga   1320

tggtgatgtt gttcatggat tctataaccc agctgttagc agaattgttg aggcgggctg   1380

tgtgtgcaat gatgctgtaa ttagaaacaa tactctaatg gggaagccaa cagaaggggc   1440

cttaattgct cttgcaatga agatgggtct tgatggactt caacaagact acatcagaaa   1500

agctgaatac ccttttagct ctgagcaaaa gtggatggct gttaagtgtg tacaccgaac   1560

acagcaggac agaccagaga tttgttttat gaaaggtgct tacgaacaag taattaagta   1620

ctgtactaca taccagagca aagggcagac cttgacactt actcagcagc agagagatgt   1680

gtaccaacaa gagaaggcac gcatgggctc agcgggactc agagttcttg ctttggcttc   1740

tggtcctgaa ctgggacagc tgacatttct tggcttggtg ggaatcattg atccacctag   1800

aactggtgtg aaagaagctg ttacaacact cattgcctca ggagtatcaa taaaaatgat   1860

tactggagat tcacaggaga ctgcagttgc aatcgccagt cgtctgggat tgtattccaa   1920

aacttcccag tcagtctcag gagaagaaat agatgcaatg gatgttcagc agctttcaca   1980

aatagtacca aaggttgcag tattttacag agctagccca aggcacaaga tgaaaattat   2040

taagtcgcta cagaagaacg gttcagttgt agccatgaca ggagatggag taaatgatgc   2100

agttgctctg aaggctgcag acattggagt tgcgatgggc cagactggta cagatgtttg   2160

caaagaggca gcagacatga tcctagtgga tgatgatttt caaaccataa tgtctgcaat   2220

cgaagagggt aaagggattt ataataacat taaaaatttc gttagattcc agctgagcac   2280

gagtatagca gcattaactt taatctcatt ggctacatta atgaactttc ctaatcctct   2340

caatgccatg cagattttgt ggatcaatat tattatggat ggacccccag ctcagagcct   2400

tggagtagaa ccagtggata aagatgtcat tcgtaaacct cctcgcaact ggaaagacag   2460

cattttgact aaaaacttga tacttaaaat acttgtttca tcaataatca ttgtttgtgg   2520

gactttgttt gtcttctggc gtgagctacg agacaatgtg attacacctc gagacacaac   2580

aatgaccttc acatgctttg tgttttttga catgttcaat gcactaagtt ccagatccca   2640

gaccaagtct gtgtttgaga ttggactctg cagtaataga atgttttgct atgcagttct   2700

tggatccatc atgggacaat tactagttat ttactttcct ccgcttcaga aggtttttca   2760

gactgagagc ctaagcatac tggatctgtt gtttcttttg ggtctcacct catcagtgtg   2820

catagtggca gaaattataa agaaggttga aaggagcagg gaaaagatcc agaagcatgt   2880

tagttcgaca tcatcatctt ttcttgaagt ctggctctgg gagaggagtg gacagcagct   2940

ggttgagata catccccatc tggagacagg actgccactg acagaagatg tgagctgtgt   3000

ctaagtccag tcttgtgccc agccgtgtct gcgccttcac tctttggaac tctgcataca   3060

acatcttagc accatcttcc tgcagctctt ccttacctaa ataaagaaac agcccaaggg   3120

cagtatttct aaaagcactg taacagcttt tcattttctc cacatatact acaaattcta   3180

taaagaaaga aattaattta aaaaaactaa gatgtttttc tcttctggct tcataaatgc   3240

cttgctgtat aaattgaaat attgatactg aactgtcttt ttaatgatga cctaacttta   3300

ttcaacccat cggaatttac tttttccctg aaataagatc ttttccactg gtctactacc   3360

tgaccataaa catgtctgca tttgaattct ctaaacccta aatctgtgtc tatgaaaaat   3420

acaaatgact attaaatatt attctcttta ctgttctctt tcaccgaaa               3469


<210>  9826
<211>  933
<212>  PRT
<213>  Homosapiens

<400>  9826

Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
1               5                   10                  15      


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
            20                  25                  30          


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
        35                  40                  45              


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
    50                  55                  60                  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
65                  70                  75                  80  


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
                85                  90                  95      


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
            100                 105                 110         


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
        115                 120                 125             


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
    130                 135                 140                 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
145                 150                 155                 160 


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
                165                 170                 175     


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
            180                 185                 190         


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
        195                 200                 205             


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
    210                 215                 220                 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
225                 230                 235                 240 


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
                245                 250                 255     


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
            260                 265                 270         


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
        275                 280                 285             


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
    290                 295                 300                 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
305                 310                 315                 320 


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
                325                 330                 335     


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
            340                 345                 350         


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
        355                 360                 365             


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
    370                 375                 380                 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
385                 390                 395                 400 


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
                405                 410                 415     


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
            420                 425                 430         


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
        435                 440                 445             


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
    450                 455                 460                 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
465                 470                 475                 480 


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
                485                 490                 495     


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
            500                 505                 510         


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
        515                 520                 525             


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
    530                 535                 540                 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
545                 550                 555                 560 


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
                565                 570                 575     


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
            580                 585                 590         


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
        595                 600                 605             


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
    610                 615                 620                 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
625                 630                 635                 640 


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
                645                 650                 655     


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
            660                 665                 670         


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
        675                 680                 685             


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
    690                 695                 700                 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
705                 710                 715                 720 


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
                725                 730                 735     


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
            740                 745                 750         


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
        755                 760                 765             


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
    770                 775                 780                 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
785                 790                 795                 800 


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
                805                 810                 815     


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
            820                 825                 830         


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
        835                 840                 845             


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
    850                 855                 860                 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
865                 870                 875                 880 


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
                885                 890                 895     


Ser Ser Ser Phe Leu Glu Val Trp Leu Trp Glu Arg Ser Gly Gln Gln 
            900                 905                 910         


Leu Val Glu Ile His Pro His Leu Glu Thr Gly Leu Pro Leu Thr Glu 
        915                 920                 925             


Asp Val Ser Cys Val 
    930             


<210>  9827
<211>  3649
<212>  DNA
<213>  Homosapiens

<400>  9827
gggaactcct tcctcagcct ctcgtcagcg ccgcttctcc tggtttctct tgcagatgct     60

gctgctaggg gtggtgggag cagccgtggg acgcgtggcc gggagcgggg gtgacagcct    120

gggattccgg gggcttctct tccttgtcct cctcctctcc tctctattcc cagtgtggcc    180

gtggctgaca ctaaagactt tgtagccatc aacccgagtg cagtttcgat ggaaaatgaa    240

ggttgcacgt tttcaaaaaa tacctaatgg tgaaaatgag acaatgattc ctgtattgac    300

atcaaaaaaa gcaagtgaat taccagtcag tgaagttgca agcattctcc aagctgatct    360

tcagaatggt ctaaacaaat gtgaagttag tcataggcga gcctttcatg gctggaatga    420

gtttgatatt agtgaagatg agccactgtg gaagaagtat atttctcagt ttaaaaatcc    480

ccttattatg ctgcttctgg cttctgcagt catcagtgtt ttaatgcatc agtttgatga    540

tgccgtcagt atcactgtgg caatacttat cgttgttaca gttgcctttg ttcaggaata    600

tcgttcagaa aaatctcttg aagaattgag taaacttgtg ccaccagaat gccattgtgt    660

gcgtgaagga aaattggagc atacacttgc ccgagacttg gttccaggtg atacagtttg    720

cctttctgtt ggggatagag ttcctgctga cttacgcttg tttgaggctg tggatctttc    780

cattgatgag tccagcttga caggtgagac aacgccttgt tctaaggtga cagctcctca    840

gccagctgca actaatggag atcttgcatc gagaagtaac attgccttta tgggaacact    900

ggtcagatgt ggcaaagcaa agggtgttgt cattggaaca ggagaaaatt ctgaatttgg    960

ggaggttttt aaaatgatgc aagcagaaga ggcaccaaaa acccctctgc agaagagcat   1020

ggacctctta ggaaaacaac tttcctttta ctcctttggt ataataggaa tcatcatgtt   1080

ggttggctgg ttactgggaa aagatatcct ggaaatgttt actattagtg taagtttggc   1140

tgtagcagca attcctgaag gtctccccat tgtggtcaca gtgacgctag ctcttggtgt   1200

tatgagaatg gtgaagaaaa gggccattgt gaaaaagctg cctattgttg aaactctggg   1260

ctgctgtaat gtgatttgtt cagataaaac tggaacactg acgaagaatg aaatgactgt   1320

tactcacata tttacttcag atggtctgca tgctgaggtt actggagttg gctataatca   1380

atttggggaa gtgattgttg atggtgatgt tgttcatgga ttctataacc cagctgttag   1440

cagaattgtt gaggcgggct gtgtgtgcaa tgatgctgta attagaaaca atactctaat   1500

ggggaagcca acagaagggg ccttaattgc tcttgcaatg aagatgggtc ttgatggact   1560

tcaacaagac tacatcagaa aagctgaata cccttttagc tctgagcaaa agtggatggc   1620

tgttaagtgt gtacaccgaa cacagcagga cagaccagag atttgtttta tgaaaggtgc   1680

ttacgaacaa gtaattaagt actgtactac ataccagagc aaagggcaga ccttgacact   1740

tactcagcag cagagagatg tgtaccaaca agagaaggca cgcatgggct cagcgggact   1800

cagagttctt gctttggctt ctggtcctga actgggacag ctgacatttc ttggcttggt   1860

gggaatcatt gatccaccta gaactggtgt gaaagaagct gttacaacac tcattgcctc   1920

aggagtatca ataaaaatga ttactggaga ttcacaggag actgcagttg caatcgccag   1980

tcgtctggga ttgtattcca aaacttccca gtcagtctca ggagaagaaa tagatgcaat   2040

ggatgttcag cagctttcac aaatagtacc aaaggttgca gtattttaca gagctagccc   2100

aaggcacaag atgaaaatta ttaagtcgct acagaagaac ggttcagttg tagccatgac   2160

aggagatgga gtaaatgatg cagttgctct gaaggctgca gacattggag ttgcgatggg   2220

ccagactggt acagatgttt gcaaagaggc agcagacatg atcctagtgg atgatgattt   2280

tcaaaccata atgtctgcaa tcgaagaggg taaagggatt tataataaca ttaaaaattt   2340

cgttagattc cagctgagca cgagtatagc agcattaact ttaatctcat tggctacatt   2400

aatgaacttt cctaatcctc tcaatgccat gcagattttg tggatcaata ttattatgga   2460

tggaccccca gctcagagcc ttggagtaga accagtggat aaagatgtca ttcgtaaacc   2520

tcctcgcaac tggaaagaca gcattttgac taaaaacttg atacttaaaa tacttgtttc   2580

atcaataatc attgtttgtg ggactttgtt tgtcttctgg cgtgagctac gagacaatgt   2640

gattacacct cgagacacaa caatgacctt cacatgcttt gtgttttttg acatgttcaa   2700

tgcactaagt tccagatccc agaccaagtc tgtgtttgag attggactct gcagtaatag   2760

aatgttttgc tatgcagttc ttggatccat catgggacaa ttactagtta tttactttcc   2820

tccgcttcag aaggtttttc agactgagag cctaagcata ctggatctgt tgtttctttt   2880

gggtctcacc tcatcagtgt gcatagtggc agaaattata aagaaggttg aaaggagcag   2940

ggaaaagatc cagaagcatg ttagttcgac atcatcatct tttcttgaag tatgatgcat   3000

attgcattat tttatttgca aactaggaat tgcagtctga ggatcattta gaagggcaag   3060

ttcaagagga tatgaagatt tgagaacttt ttaactattc attgactaaa aatgaacatt   3120

aatgttaaag acttaagact ttaacctgct ggcagtccca aatgaaatta tgcaactttg   3180

atatcatatt ccttgattta aattggcttt tgtgattgag tgaaacttta taaagcatat   3240

ggtcagttat ttaattaaaa aggcaaaacc tgaaccacct tctgcactta aagaagtcta   3300

acagtacaaa tacactatct atcttagata gatatatttt tttttatttt taaatattgt   3360

actatttatg gtggtggggc tttcttacta atacacaaat aaatttaatc atttcaaagg   3420

cattctattt ggtttagaag ttgattccca ggagtgccat atttcagcta ctgtatttcc   3480

tttttcttgt aatgtaagca gctcagatac catgtgctat catttttgta tcaagttttt   3540

tgcacaggat gtgaccactg tcagatcact gttcttttct ttctttttgt gattgaaaag   3600

cctatactac aatttgaagt aaatttttgt ttttcttagt aagtgtaaa               3649


<210>  9828
<211>  919
<212>  PRT
<213>  Homosapiens

<400>  9828

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val 
        915                 


<210>  9829
<211>  4793
<212>  DNA
<213>  Homosapiens

<400>  9829
gggaactcct tcctcagcct ctcgtcagcg ccgcttctcc tggtttctct tgcagatgct     60

gctgctaggg gtggtgggag cagccgtggg acgcgtggcc gggagcgggg gtgacagcct    120

gggattccgg gggcttctct tccttgtcct cctcctctcc tctctattcc cagtgtggcc    180

gtggctgaca ctaaagactt tgtagccatc aacccgagtg cagtttcgat ggaaaatgaa    240

ggttgcacgt tttcaaaaaa tacctaatgg tgaaaatgag acaatgattc ctgtattgac    300

atcaaaaaaa gcaagtgaat taccagtcag tgaagttgca agcattctcc aagctgatct    360

tcagaatggt ctaaacaaat gtgaagttag tcataggcga gcctttcatg gctggaatga    420

gtttgatatt agtgaagatg agccactgtg gaagaagtat atttctcagt ttaaaaatcc    480

ccttattatg ctgcttctgg cttctgcagt catcagtgtt ttaatgcatc agtttgatga    540

tgccgtcagt atcactgtgg caatacttat cgttgttaca gttgcctttg ttcaggaata    600

tcgttcagaa aaatctcttg aagaattgag taaacttgtg ccaccagaat gccattgtgt    660

gcgtgaagga aaattggagc atacacttgc ccgagacttg gttccaggtg atacagtttg    720

cctttctgtt ggggatagag ttcctgctga cttacgcttg tttgaggctg tggatctttc    780

cattgatgag tccagcttga caggtgagac aacgccttgt tctaaggtga cagctcctca    840

gccagctgca actaatggag atcttgcatc gagaagtaac attgccttta tgggaacact    900

ggtcagatgt ggcaaagcaa agggtgttgt cattggaaca ggagaaaatt ctgaatttgg    960

ggaggttttt aaaatgatgc aagcagaaga ggcaccaaaa acccctctgc agaagagcat   1020

ggacctctta ggaaaacaac tttcctttta ctcctttggt ataataggaa tcatcatgtt   1080

ggttggctgg ttactgggaa aagatatcct ggaaatgttt actattagtg taagtttggc   1140

tgtagcagca attcctgaag gtctccccat tgtggtcaca gtgacgctag ctcttggtgt   1200

tatgagaatg gtgaagaaaa gggccattgt gaaaaagctg cctattgttg aaactctggg   1260

ctgctgtaat gtgatttgtt cagataaaac tggaacactg acgaagaatg aaatgactgt   1320

tactcacata tttacttcag atggtctgca tgctgaggtt actggagttg gctataatca   1380

atttggggaa gtgattgttg atggtgatgt tgttcatgga ttctataacc cagctgttag   1440

cagaattgtt gaggcgggct gtgtgtgcaa tgatgctgta attagaaaca atactctaat   1500

ggggaagcca acagaagggg ccttaattgc tcttgcaatg aagatgggtc ttgatggact   1560

tcaacaagac tacatcagaa aagctgaata cccttttagc tctgagcaaa agtggatggc   1620

tgttaagtgt gtacaccgaa cacagcagga cagaccagag atttgtttta tgaaaggtgc   1680

ttacgaacaa gtaattaagt actgtactac ataccagagc aaagggcaga ccttgacact   1740

tactcagcag cagagagatg tgtaccaaca agagaaggca cgcatgggct cagcgggact   1800

cagagttctt gctttggctt ctggtcctga actgggacag ctgacatttc ttggcttggt   1860

gggaatcatt gatccaccta gaactggtgt gaaagaagct gttacaacac tcattgcctc   1920

aggagtatca ataaaaatga ttactggaga ttcacaggag actgcagttg caatcgccag   1980

tcgtctggga ttgtattcca aaacttccca gtcagtctca ggagaagaaa tagatgcaat   2040

ggatgttcag cagctttcac aaatagtacc aaaggttgca gtattttaca gagctagccc   2100

aaggcacaag atgaaaatta ttaagtcgct acagaagaac ggttcagttg tagccatgac   2160

aggagatgga gtaaatgatg cagttgctct gaaggctgca gacattggag ttgcgatggg   2220

ccagactggt acagatgttt gcaaagaggc agcagacatg atcctagtgg atgatgattt   2280

tcaaaccata atgtctgcaa tcgaagaggg taaagggatt tataataaca ttaaaaattt   2340

cgttagattc cagctgagca cgagtatagc agcattaact ttaatctcat tggctacatt   2400

aatgaacttt cctaatcctc tcaatgccat gcagattttg tggatcaata ttattatgga   2460

tggaccccca gctcagagcc ttggagtaga accagtggat aaagatgtca ttcgtaaacc   2520

tcctcgcaac tggaaagaca gcattttgac taaaaacttg atacttaaaa tacttgtttc   2580

atcaataatc attgtttgtg ggactttgtt tgtcttctgg cgtgagctac gagacaatgt   2640

gattacacct cgagacacaa caatgacctt cacatgcttt gtgttttttg acatgttcaa   2700

tgcactaagt tccagatccc agaccaagtc tgtgtttgag attggactct gcagtaatag   2760

aatgttttgc tatgcagttc ttggatccat catgggacaa ttactagtta tttactttcc   2820

tccgcttcag aaggtttttc agactgagag cctaagcata ctggatctgt tgtttctttt   2880

gggtctcacc tcatcagtgt gcatagtggc agaaattata aagaaggttg aaaggagcag   2940

ggaaaagatc cagaagcatg ttagttcgac atcatcatct tttcttgaag tatgatgcat   3000

attgcattat tttatttgca aactaggaat tgcagtctga ggatcattta gaagggcaag   3060

ttcaagagga tatgaagatt tgagaacttt ttaactattc attgactaaa aatgaacatt   3120

aatgttaaag acttaagact ttaacctgct ggcagtccca aatgaaatta tgcaactttg   3180

atatcatatt ccttgattta aattggcttt tgtgattgag tgaaacttta taaagcatat   3240

ggtcagttat ttaattaaaa aggcaaaacc tgaaccacct tctgcactta aagaagtcta   3300

acagtacaaa tacactatct atcttagata gatatatttt tttttatttt taaatattgt   3360

actatttatg gtggtggggc tttcttacta atacacaaat aaatttaatc atttcaaagg   3420

cattctattt ggtttagaag ttgattccca ggagtgccat atttcagcta ctgtatttcc   3480

tttttcttgt aatgtaagca gctcagatac catgtgctat catttttgta tcaagttttt   3540

tgcacaggat gtgaccactg tcagatcact gttcttttct ttctttttgt gattgaaaag   3600

cctatactac aatttgaagt aaatttttgt ttttcttagt aagtgtaaat ggttgcttta   3660

tttttatttt aaaaaggtat gtctttggtt tggcagaatt catgcagggc tatcaagtgg   3720

tgttctaggg taacagtgtc cataattaac gcttagtcat agagtcaaaa acatttaaga   3780

ctgattgggt tgaagtttat aataaattat attaacatgt cttccttttt gaggtaaaga   3840

tatatacttt gtcaaatatc attttgtcat cctctaaata taaatccaaa tacctcagct   3900

aagtaattct attttattat ttttactgtt atgtatgttt ttaatcatat ttcttaggaa   3960

gtataggcta ctggacttag aataaaaagt ccccaaaccc aaacaaatgg tttatgaacc   4020

agagtatatg tggaagattc tttgctggtc ttgctctgtg tgcatctgaa gcttctttgg   4080

cctagatttt agcacaaacc tgagtatatc tcttctactt tcatcatgtg ttctgtacct   4140

tctttttgtt tcattgggca tgctagggaa ataggtggat tttgtgtgta atgccatcag   4200

tttttatgaa agcttgatga ggtataggtc atttgttttg agtatgtggg ccagaaattt   4260

aaaattagaa atttgttttt ctgttgagta tataaacaaa aattggtccc aattctaaca   4320

ggtttaatcc ttcttgaagc caataagttt tatcttttat aatctgtcag gatgaaccac   4380

tccttagctt ttatccaata ttaaactgca agtgttagca ctgaaatatt gtcattgata   4440

gggaaaatat ctattctttg agtcattgtt actgaggcag ttgagtgtaa ggagctggct   4500

gcagtttatt ctacttaacc ctttaaggct gaattgtcaa atgtacattg ttccatgtcg   4560

ttagatggaa catggaagcc attgtctaat caactctatc attagtgact tgatgtctca   4620

taccttaatt ttgtaatgat ttttattctc tgttacaaag acttgaaata cgtattaaat   4680

gcacgttaat gttttgcttt gcattttagg ttcagattat gacttgattg aaataaatgt   4740

gcctatacat tcatttgctt tgtactataa aaataaaaat gatttcttaa gtt          4793


<210>  9830
<211>  919
<212>  PRT
<213>  Homosapiens

<400>  9830

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val 
        915                 


<210>  9831
<211>  4884
<212>  DNA
<213>  Homosapiens

<400>  9831
gggaactcct tcctcagcct ctcgtcagcg ccgcttctcc tggtttctct tgcagatgct     60

gctgctaggg gtggtgggag cagccgtggg acgcgtggcc gggagcgggg gtgacagcct    120

gggattccgg gggcttctct tccttgtcct cctcctctcc tctctattcc cagtgtggcc    180

gtggctgaca ctaaagactt tgtagccatc aacccgagtg cagtttcgat ggaaaatgaa    240

ggttgcacgt tttcaaaaaa tacctaatgg tgaaaatgag acaatgattc ctgtattgac    300

atcaaaaaaa gcaagtgaat taccagtcag tgaagttgca agcattctcc aagctgatct    360

tcagaatggt ctaaacaaat gtgaagttag tcataggcga gcctttcatg gctggaatga    420

gtttgatatt agtgaagatg agccactgtg gaagaagtat atttctcagt ttaaaaatcc    480

ccttattatg ctgcttctgg cttctgcagt catcagtgtt ttaatgcatc agtttgatga    540

tgccgtcagt atcactgtgg caatacttat cgttgttaca gttgcctttg ttcaggaata    600

tcgttcagaa aaatctcttg aagaattgag taaacttgtg ccaccagaat gccattgtgt    660

gcgtgaagga aaattggagc atacacttgc ccgagacttg gttccaggtg atacagtttg    720

cctttctgtt ggggatagag ttcctgctga cttacgcttg tttgaggctg tggatctttc    780

cattgatgag tccagcttga caggtgagac aacgccttgt tctaaggtga cagctcctca    840

gccagctgca actaatggag atcttgcatc gagaagtaac attgccttta tgggaacact    900

ggtcagatgt ggcaaagcaa agggtgttgt cattggaaca ggagaaaatt ctgaatttgg    960

ggaggttttt aaaatgatgc aagcagaaga ggcaccaaaa acccctctgc agaagagcat   1020

ggacctctta ggaaaacaac tttcctttta ctcctttggt ataataggaa tcatcatgtt   1080

ggttggctgg ttactgggaa aagatatcct ggaaatgttt actattagtg taagtttggc   1140

tgtagcagca attcctgaag gtctccccat tgtggtcaca gtgacgctag ctcttggtgt   1200

tatgagaatg gtgaagaaaa gggccattgt gaaaaagctg cctattgttg aaactctggg   1260

ctgctgtaat gtgatttgtt cagataaaac tggaacactg acgaagaatg aaatgactgt   1320

tactcacata tttacttcag atggtctgca tgctgaggtt actggagttg gctataatca   1380

atttggggaa gtgattgttg atggtgatgt tgttcatgga ttctataacc cagctgttag   1440

cagaattgtt gaggcgggct gtgtgtgcaa tgatgctgta attagaaaca atactctaat   1500

ggggaagcca acagaagggg ccttaattgc tcttgcaatg aagatgggtc ttgatggact   1560

tcaacaagac tacatcagaa aagctgaata cccttttagc tctgagcaaa agtggatggc   1620

tgttaagtgt gtacaccgaa cacagcagga cagaccagag atttgtttta tgaaaggtgc   1680

ttacgaacaa gtaattaagt actgtactac ataccagagc aaagggcaga ccttgacact   1740

tactcagcag cagagagatg tgtaccaaca agagaaggca cgcatgggct cagcgggact   1800

cagagttctt gctttggctt ctggtcctga actgggacag ctgacatttc ttggcttggt   1860

gggaatcatt gatccaccta gaactggtgt gaaagaagct gttacaacac tcattgcctc   1920

aggagtatca ataaaaatga ttactggaga ttcacaggag actgcagttg caatcgccag   1980

tcgtctggga ttgtattcca aaacttccca gtcagtctca ggagaagaaa tagatgcaat   2040

ggatgttcag cagctttcac aaatagtacc aaaggttgca gtattttaca gagctagccc   2100

aaggcacaag atgaaaatta ttaagtcgct acagaagaac ggttcagttg tagccatgac   2160

aggagatgga gtaaatgatg cagttgctct gaaggctgca gacattggag ttgcgatggg   2220

ccagactggt acagatgttt gcaaagaggc agcagacatg atcctagtgg atgatgattt   2280

tcaaaccata atgtctgcaa tcgaagaggg taaagggatt tataataaca ttaaaaattt   2340

cgttagattc cagctgagca cgagtatagc agcattaact ttaatctcat tggctacatt   2400

aatgaacttt cctaatcctc tcaatgccat gcagattttg tggatcaata ttattatgga   2460

tggaccccca gctcagagcc ttggagtaga accagtggat aaagatgtca ttcgtaaacc   2520

tcctcgcaac tggaaagaca gcattttgac taaaaacttg atacttaaaa tacttgtttc   2580

atcaataatc attgtttgtg ggactttgtt tgtcttctgg cgtgagctac gagacaatgt   2640

gattacacct cgagacacaa caatgacctt cacatgcttt gtgttttttg acatgttcaa   2700

tgcactaagt tccagatccc agaccaagtc tgtgtttgag attggactct gcagtaatag   2760

aatgttttgc tatgcagttc ttggatccat catgggacaa ttactagtta tttactttcc   2820

tccgcttcag aaggtttttc agactgagag cctaagcata ctggatctgt tgtttctttt   2880

gggtctcacc tcatcagtgt gcatagtggc agaaattata aagaaggttg aaaggagcag   2940

ggaaaagatc cagaagcatg ttagttcgac atcatcatct tttcttgaag tatgatgcat   3000

attgcattat tttatttgca aactaggaat tgcagtctga ggatcattta gaagggcaag   3060

ttcaagagga tatgaagatt tgagaacttt ttaactattc attgactaaa aatgaacatt   3120

aatgttaaag acttaagact ttaacctgct ggcagtccca aatgaaatta tgcaactttg   3180

atatcatatt ccttgattta aattggcttt tgtgattgag tgaaacttta taaagcatat   3240

ggtcagttat ttaattaaaa aggcaaaacc tgaaccacct tctgcactta aagaagtcta   3300

acagtacaaa tacactatct atcttagata gatatatttt tttttatttt taaatattgt   3360

actatttatg gtggtggggc tttcttacta atacacaaat aaatttaatc atttcaaagg   3420

cattctattt ggtttagaag ttgattccca ggagtgccat atttcagcta ctgtatttcc   3480

tttttcttgt aatgtaagca gctcagatac catgtgctat catttttgta tcaagttttt   3540

tgcacaggat gtgaccactg tcagatcact gttcttttct ttctttttgt gattgaaaag   3600

cctatactac aatttgaagt aaatttttgt ttttcttagt aagtgtaaat ggttgcttta   3660

tttttatttt aaaaaggtat gtctttggtt tggcagaatt catgcagggc tatcaagtgg   3720

tgttctaggg taacagtgtc cataattaac gcttagtcat agagtcaaaa acatttaaga   3780

ctgattgggt tgaagtttat aataaattat attaacatgt cttccttttt gaggtaaaga   3840

tatatacttt gtcaaatatc attttgtcat cctctaaata taaatccaaa tacctcagct   3900

aagtaattct attttattat ttttactgtt atgtatgttt ttaatcatat ttcttaggaa   3960

gtataggcta ctggacttag aataaaaagt ccccaaaccc aaacaaatgg tttatgaacc   4020

agagtatatg tggaagattc tttgctggtc ttgctctgtg tgcatctgaa gcttctttgg   4080

cctagatttt agcacaaacc tgagtatatc tcttctactt tcatcatgtg ttctgtacct   4140

tctttttgtt tcattgggca tgctagggaa ataggtggat tttgtgtgta atgccatcag   4200

tttttatgaa agcttgatga ggtataggtc atttgttttg agtatgtggg ccagaaattt   4260

aaaattagaa atttgttttt ctgttgagta tataaacaaa aattggtccc aattctaaca   4320

ggtttaatcc ttcttgaagc caataagttt tatcttttat aatctgtcag gatgaaccac   4380

tccttagctt ttatccaata ttaaactgca agtgttagca ctgaaatatt gtcattgata   4440

gggaaaatat ctattctttg agtcattgtt actgaggcag ttgagtgtaa ggagctggct   4500

gcagtttatt ctacttaacc ctttaaggct gaattgtcaa atgtacattg ttccatgtcg   4560

ttagatggaa catggaagcc attgtctaat caactctatc attagtgact tgatgtctca   4620

taccttaatt ttgtaatgat ttttattctc tgttacaaag acttgaaata cgtattaaat   4680

gcacgttaat gttttgcttt gcattttagg ttcagattat gacttgattg aaataaatgt   4740

gcctatacat tcatttgctt tgtactataa aaataaaaat gatttcttaa gttaatgaca   4800

tcccagtggg gactattagc attaaaatta tccatatgga tgctgaagat acagaaatta   4860

aaattatcca tatggatgct ggag                                          4884


<210>  9832
<211>  919
<212>  PRT
<213>  Homosapiens

<400>  9832

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val 
        915                 


<210>  9833
<211>  3396
<212>  DNA
<213>  Homosapiens

<400>  9833
gggaactcct tcctcagcct ctcgtcagcg ccgcttctcc tggtttctct tgcagatgct     60

gctgctaggg gtggtgggag cagccgtggg acgcgtggcc gggagcgggg gtgacagcct    120

gggattccgg gggcttctct tccttgtcct cctcctctcc tctctattcc cagtgtggcc    180

gtggctgaca ctaaagactt tgtagccatc aacccgagtg cagtttcgat ggaaaatgaa    240

ggttgcacgt tttcaaaaaa tacctaatgg tgaaaatgag acaatgattc ctgtattgac    300

atcaaaaaaa gcaagtgaat taccagtcag tgaagttgca agcattctcc aagctgatct    360

tcagaatggt ctaaacaaat gtgaagttag tcataggcga gcctttcatg gctggaatga    420

gtttgatatt agtgaagatg agccactgtg gaagaagtat atttctcagt ttaaaaatcc    480

ccttattatg ctgcttctgg cttctgcagt catcagtgtt ttaatgcatc agtttgatga    540

tgccgtcagt atcactgtgg caatacttat cgttgttaca gttgcctttg ttcaggaata    600

tcgttcagaa aaatctcttg aagaattgag taaacttgtg ccaccagaat gccattgtgt    660

gcgtgaagga aaattggagc atacacttgc ccgagacttg gttccaggtg atacagtttg    720

cctttctgtt ggggatagag ttcctgctga cttacgcttg tttgaggctg tggatctttc    780

cattgatgag tccagcttga caggtgagac aacgccttgt tctaaggtga cagctcctca    840

gccagctgca actaatggag atcttgcatc gagaagtaac attgccttta tgggaacact    900

ggtcagatgt ggcaaagcaa agggtgttgt cattggaaca ggagaaaatt ctgaatttgg    960

ggaggttttt aaaatgatgc aagcagaaga ggcaccaaaa acccctctgc agaagagcat   1020

ggacctctta ggaaaacaac tttcctttta ctcctttggt ataataggaa tcatcatgtt   1080

ggttggctgg ttactgggaa aagatatcct ggaaatgttt actattagtg taagtttggc   1140

tgtagcagca attcctgaag gtctccccat tgtggtcaca gtgacgctag ctcttggtgt   1200

tatgagaatg gtgaagaaaa gggccattgt gaaaaagctg cctattgttg aaactctggg   1260

ctgctgtaat gtgatttgtt cagataaaac tggaacactg acgaagaatg aaatgactgt   1320

tactcacata tttacttcag atggtctgca tgctgaggtt actggagttg gctataatca   1380

atttggggaa gtgattgttg atggtgatgt tgttcatgga ttctataacc cagctgttag   1440

cagaattgtt gaggcgggct gtgtgtgcaa tgatgctgta attagaaaca atactctaat   1500

ggggaagcca acagaagggg ccttaattgc tcttgcaatg aagatgggtc ttgatggact   1560

tcaacaagac tacatcagaa aagctgaata cccttttagc tctgagcaaa agtggatggc   1620

tgttaagtgt gtacaccgaa cacagcagga cagaccagag atttgtttta tgaaaggtgc   1680

ttacgaacaa gtaattaagt actgtactac ataccagagc aaagggcaga ccttgacact   1740

tactcagcag cagagagatg tgtaccaaca agagaaggca cgcatgggct cagcgggact   1800

cagagttctt gctttggctt ctggtcctga actgggacag ctgacatttc ttggcttggt   1860

gggaatcatt gatccaccta gaactggtgt gaaagaagct gttacaacac tcattgcctc   1920

aggagtatca ataaaaatga ttactggaga ttcacaggag actgcagttg caatcgccag   1980

tcgtctggga ttgtattcca aaacttccca gtcagtctca ggagaagaaa tagatgcaat   2040

ggatgttcag cagctttcac aaatagtacc aaaggttgca gtattttaca gagctagccc   2100

aaggcacaag atgaaaatta ttaagtcgct acagaagaac ggttcagttg tagccatgac   2160

aggagatgga gtaaatgatg cagttgctct gaaggctgca gacattggag ttgcgatggg   2220

ccagactggt acagatgttt gcaaagaggc agcagacatg atcctagtgg atgatgattt   2280

tcaaaccata atgtctgcaa tcgaagaggg taaagggatt tataataaca ttaaaaattt   2340

cgttagattc cagctgagca cgagtatagc agcattaact ttaatctcat tggctacatt   2400

aatgaacttt cctaatcctc tcaatgccat gcagattttg tggatcaata ttattatgga   2460

tggaccccca gctcagagcc ttggagtaga accagtggat aaagatgtca ttcgtaaacc   2520

tcctcgcaac tggaaagaca gcattttgac taaaaacttg atacttaaaa tacttgtttc   2580

atcaataatc attgtttgtg ggactttgtt tgtcttctgg cgtgagctac gagacaatgt   2640

gattacacct cgagacacaa caatgacctt cacatgcttt gtgttttttg acatgttcaa   2700

tgcactaagt tccagatccc agaccaagtc tgtgtttgag attggactct gcagtaatag   2760

aatgttttgc tatgcagttc ttggatccat catgggacaa ttactagtta tttactttcc   2820

tccgcttcag aaggtttttc agactgagag cctaagcata ctgggtctgg ctctgggaga   2880

ggagtggaca gcagctggtt gagatacatc cccatctgga gacaggactg ccactgacag   2940

aagatgtgag ctgtgtctaa gtccagtctt gtgcccagcc gtgtctgcgc cttcactctt   3000

tggaactctg catacaacat cttagcacca tcttcctgca gctcttcctt acctaaataa   3060

agaaacagcc caagggcagt atttctaaaa gcactgtaac agcttttcat tttctccaca   3120

tatactacaa attctataaa gaaagaaatt aatttaaaaa aactaagatg tttttctctt   3180

ctggcttcat aaatgccttg ctgtataaat tgaaatattg atactgaact gtctttttaa   3240

tgatgaccta actttattca acccatcgga atttactttt tccctgaaat aagatctttt   3300

ccactggtct actacctgac cataaacatg tctgcatttg aattctctaa accctaaatc   3360

tgtgtctatg aaaaatacaa atgactatta aatatt                             3396


<210>  9834
<211>  888
<212>  PRT
<213>  Homosapiens

<400>  9834

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Gly Leu Ala Leu 
865                 870                 875                 880 


Gly Glu Glu Trp Thr Ala Ala Gly 
                885             


<210>  9835
<211>  3425
<212>  DNA
<213>  Homosapiens

<400>  9835
gggaactcct tcctcagcct ctcgtcagcg ccgcttctcc tggtttctct tgcagatgct     60

gctgctaggg gtggtgggag cagccgtggg acgcgtggcc gggagcgggg gtgacagcct    120

gggattccgg gggcttctct tccttgtcct cctcctctcc tctctattcc cagtgtggcc    180

gtggctgaca ctaaagactt tgtagccatc aacccgagtg cagtttcgat ggaaaatgaa    240

ggttgcacgt tttcaaaaaa tacctaatgg tgaaaatgag acaatgattc ctgtattgac    300

atcaaaaaaa gcaagtgaat taccagtcag tgaagttgca agcattctcc aagctgatct    360

tcagaatggt ctaaacaaat gtgaagttag tcataggcga gcctttcatg gctggaatga    420

gtttgatatt agtgaagatg agccactgtg gaagaagtat atttctcagt ttaaaaatcc    480

ccttattatg ctgcttctgg cttctgcagt catcagtgtt ttaatgcatc agtttgatga    540

tgccgtcagt atcactgtgg caatacttat cgttgttaca gttgcctttg ttcaggaata    600

tcgttcagaa aaatctcttg aagaattgag taaacttgtg ccaccagaat gccattgtgt    660

gcgtgaagga aaattggagc atacacttgc ccgagacttg gttccaggtg atacagtttg    720

cctttctgtt ggggatagag ttcctgctga cttacgcttg tttgaggctg tggatctttc    780

cattgatgag tccagcttga caggtgagac aacgccttgt tctaaggtga cagctcctca    840

gccagctgca actaatggag atcttgcatc gagaagtaac attgccttta tgggaacact    900

ggtcagatgt ggcaaagcaa agggtgttgt cattggaaca ggagaaaatt ctgaatttgg    960

ggaggttttt aaaatgatgc aagcagaaga ggcaccaaaa acccctctgc agaagagcat   1020

ggacctctta ggaaaacaac tttcctttta ctcctttggt ataataggaa tcatcatgtt   1080

ggttggctgg ttactgggaa aagatatcct ggaaatgttt actattagtg taagtttggc   1140

tgtagcagca attcctgaag gtctccccat tgtggtcaca gtgacgctag ctcttggtgt   1200

tatgagaatg gtgaagaaaa gggccattgt gaaaaagctg cctattgttg aaactctggg   1260

ctgctgtaat gtgatttgtt cagataaaac tggaacactg acgaagaatg aaatgactgt   1320

tactcacata tttacttcag atggtctgca tgctgaggtt actggagttg gctataatca   1380

atttggggaa gtgattgttg atggtgatgt tgttcatgga ttctataacc cagctgttag   1440

cagaattgtt gaggcgggct gtgtgtgcaa tgatgctgta attagaaaca atactctaat   1500

ggggaagcca acagaagggg ccttaattgc tcttgcaatg aagatgggtc ttgatggact   1560

tcaacaagac tacatcagaa aagctgaata cccttttagc tctgagcaaa agtggatggc   1620

tgttaagtgt gtacaccgaa cacagcagga cagaccagag atttgtttta tgaaaggtgc   1680

ttacgaacaa gtaattaagt actgtactac ataccagagc aaagggcaga ccttgacact   1740

tactcagcag cagagagatg tgtaccaaca agagaaggca cgcatgggct cagcgggact   1800

cagagttctt gctttggctt ctggtcctga actgggacag ctgacatttc ttggcttggt   1860

gggaatcatt gatccaccta gaactggtgt gaaagaagct gttacaacac tcattgcctc   1920

aggagtatca ataaaaatga ttactggaga ttcacaggag actgcagttg caatcgccag   1980

tcgtctggga ttgtattcca aaacttccca gtcagtctca ggagaagaaa tagatgcaat   2040

ggatgttcag cagctttcac aaatagtacc aaaggttgca gtattttaca gagctagccc   2100

aaggcacaag atgaaaatta ttaagtcgct acagaagaac ggttcagttg tagccatgac   2160

aggagatgga gtaaatgatg cagttgctct gaaggctgca gacattggag ttgcgatggg   2220

ccagactggt acagatgttt gcaaagaggc agcagacatg atcctagtgg atgatgattt   2280

tcaaaccata atgtctgcaa tcgaagaggg taaagggatt tataataaca ttaaaaattt   2340

cgttagattc cagctgagca cgagtatagc agcattaact ttaatctcat tggctacatt   2400

aatgaacttt cctaatcctc tcaatgccat gcagattttg tggatcaata ttattatgga   2460

tggaccccca gctcagagcc ttggagtaga accagtggat aaagatgtca ttcgtaaacc   2520

tcctcgcaac tggaaagaca gcattttgac taaaaacttg atacttaaaa tacttgtttc   2580

atcaataatc attgtttgtg ggactttgtt tgtcttctgg cgtgagctac gagacaatgt   2640

gattacacct cgagacacaa caatgacctt cacatgcttt gtgttttttg acatgttcaa   2700

tgcactaagt tccagatccc agaccaagtc tgtgtttgag attggactct gcagtaatag   2760

aatgttttgc tatgcagttc ttggatccat catgggacaa ttactagtta tttactttcc   2820

tccgcttcag aaggtttttc agactgagag cctaagcata ctgggtctgg ctctgggaga   2880

ggagtggaca gcagctggtt gagatacatc cccatctgga gacaggactg ccactgacag   2940

aagatgtgag ctgtgtctaa gtccagtctt gtgcccagcc gtgtctgcgc cttcactctt   3000

tggaactctg catacaacat cttagcacca tcttcctgca gctcttcctt acctaaataa   3060

agaaacagcc caagggcagt atttctaaaa gcactgtaac agcttttcat tttctccaca   3120

tatactacaa attctataaa gaaagaaatt aatttaaaaa aactaagatg tttttctctt   3180

ctggcttcat aaatgccttg ctgtataaat tgaaatattg atactgaact gtctttttaa   3240

tgatgaccta actttattca acccatcgga atttactttt tccctgaaat aagatctttt   3300

ccactggtct actacctgac cataaacatg tctgcatttg aattctctaa accctaaatc   3360

tgtgtctatg aaaaatacaa atgactatta aatattattc tctttactgt tctctttcac   3420

cgaaa                                                               3425


<210>  9836
<211>  888
<212>  PRT
<213>  Homosapiens

<400>  9836

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


A